bluuebunny/crossref_metadata_2025_split huggingface dataset:
Initial Heart Rate Score Predicts New Onset Atrial Fibrillation in Pacemaker Patients
Authors: Hayashi Katsuhide , Abe Haruhiko , Olshansky Brian , Sharma Arjun D. , Jones Paul W. , Wold Nickolas , Perschbacher David , Kohno Ritsuko , Richards Mark , Wilkoff Bruce L. 
Published: February 2023

AbstractBackgroundHeart Rate Score (HRSc), the percent of all atrial paced and sensed event in the largest 10 bpm rate histogram bin of a pacemaker, predicts survival in patients with cardiac devices. No correlation between HRSc and development of atrial fibrillation (AF) has been reported.ObjectiveTo evaluate the relationship between pacemaker post-implantation HRSc and newly-developed AF incidence.MethodsPatients with dual-chamber pacemakers, implanted 2013-2017, with ALTITIUDE remote monitoring data with ≥600,000 beats of histogram data collected at baseline were included (N=34,543). HRSc was determined from the post-implantation histogram data during the initial 3 months. Patients were excluded if they had AF, defined as atrial high-rate episodes >5 minutes or >1% of right atrial beats >170 bpm during the initial 3-months post-implantation. New AF, after the baseline period, was defined by each of the following: >1%, >10% or >25% of atrial beats >170 bpm or Atrial Tachycardia Response (ATR) events >24 hr.ResultsPatients were followed a median of 2.8 (1.0-4.0) years. Patients with initial HRSc≥70% were older, had higher %RA pacing, had lower %RV pacing and were more likely programmed with rate-response vs subjects with HRSc<70%. The incidence of AF increased in proportion to HRSc (Log-Rank P-value <0.001); results were insensitive to AF definition. Initial HRSc (HR:1.07, 95% CI:1.05-1.09; P<0.0001) independently predicted AF after adjusting for age, gender, % RV pacing and rate-response programming. The %RA pacing and initial HRSc correlated.ConclusionHRSc predicts subsequent AF independent of well-known risk factors in pacemaker patients.
Association of childhood adversity with frailty and the mediating role of unhealthy lifestyle: Findings from the UK biobank
Authors: Yang Gan , Cao Xingqi , Yu Jie , Li Xueqin , Zhang Liming , Zhang Jingyun , Ma Chao , Zhang Ning , Lu Qingyun , Wu Chenkai , Chen Xi , Hoogendijk Emiel O. , Gill Thomas M. , Liu Zuyun 
Published: February 2023

AbstractBackgroundChildhood adversity and lifestyle have been associated with frailty in later life, but not much is known about factors that may explain these associations. An unhealthy lifestyle may play an important role in the pathway from childhood adversity to frailty. Therefore, this study aims to investigate the association of childhood adversity with frailty, and the mediating role of unhealthy lifestyle in the association.MethodsThis lifespan analysis included 152914 adults aged 40-69 years old from the UK Biobank. We measured childhood adversity with five items: physical neglect, emotional neglect, sexual abuse, physical abuse, and emotional abuse through online mental health survey. Frailty was measured by the frailty index; an unhealthy lifestyle score (range: 0-5) was calculated based on unhealthy body mass index, smoking, drinking, physical inactivity, and unhealthy diet at the baseline survey. Multiple logistic regression and mediation analysis were performed.ResultsA total of 10078 participants (6.6%) were defined as having frailty. Participants with any childhood adversity had higher odds of frailty. For example, in the fully adjusted model, with a one-point increase in cumulative score of childhood adversity, the odds of frailty increased by 41% (Odds Ratio: 1.41; 95% Confidence Interval: 1.39, 1.44). Unhealthy lifestyle partially mediated the associations of childhood adversity with frailty (mediation proportion: 4.4%-7.0%). The mediation proportions were largest for physical (8.2%) and sexual (8.1%) abuse.ConclusionsAmong this large sample, childhood adversity was positively associated with frailty, and unhealthy lifestyle partially mediated the association. This newly identified pathway highlights the potential of lifestyle intervention strategies among those who experienced childhood adversity (in particular, physical and sexual abuse) to promote healthy aging.
Transcriptome-wide association study identified candidate genes associated with polycystic ovary syndrome
Authors: Shi Yingzhou , Li Changrong , Yu Hongjie , Chen Xinyu , Shi Ping , Xu Chao 
Published: February 2023

AbstractPolycystic ovary syndrome (PCOS) is one of the most common metabolism and endocrine disorder affecting women of reproductive age. However, the genetic mechanisms of PCOS remain largely elusive. A transcriptome-wide association study(TWAS) was conducted to identify the genes associated with PCOS using gene expression references of the whole blood and ovary. Then mRNA expression profiling analysis was performed to identify common genes with TWAS. Genes detected by TWAS were subjected to Gene Ontology(GO), pathway enrichment and protein-protein analysis. TWAS identified 422 genes for the whole blood and 177 genes for ovary, such as EML6 (TWAS.P = 6.33E-05), GRAP (TWAS.P = 0.000211), MAFTRR(TWAS.P = 1.21E-05). Functional enrichment analysis detected biological processes including ncRNA metabolic process, microtubule-related pathways. The present study identified a number of potential PCOS genes and biological processes. These results may provide insight into the genetic basis of PCOS.
Understanding depression in female adolescents: Correlations between interpersonal trust, self-esteem, and interpersonal attributional style
Authors: Li Lin , Tang Lan , Lai Yan-hong , Liu Jian 
Published: February 2023

AbstractThis study examines sociocognitive factors causing depressed mood in hospitalized female adolescents with depression and the correlations between interpersonal trust, self-esteem, and interpersonal attributional style. From June 2021 to October 2022, a total of 166 hospitalized female adolescents with depression who met the inclusion criteria were recruited from Hangzhou Seventh People’s Hospital. They provided demographic information and were evaluated for depressed mood, interpersonal trust, self-esteem, and interpersonal attributional style using the Chinese versions of the Children’s Depression Inventory, Interpersonal Trust Scale, Rosenberg Self-Esteem Scale, and Multidimensional–Multiattributional Causality Scale, respectively. Interpersonal trust and self-esteem were negatively correlated with depressed mood, whereas internal and external attributions of interpersonal attributional style were significantly and positively correlated with depressed mood. Interpersonal trust was significantly and positively correlated with self-esteem, and interpersonal trust and self-esteem were negatively correlated with interpersonal attributional style. An analysis of the theoretical model for interpersonal trust–self-esteem– interpersonal attributional style–depressed mood relationships revealed that the model had a good fit and the overall fit indicators met the statistical requirements. The results of the path coefficient analysis indicated that all path coefficients reached statistically significant levels, except for those from interpersonal trust to depressed mood. Therefore, self-esteem mediates the effects of interpersonal trust and interpersonal attributional style on depression and is a critical sociocognitive factor affecting female adolescents with depression. Accordingly, psychological interventions for female adolescents with depression should focus on improving self-esteem.
Real-world effectiveness of molnupiravir and nirmatrelvir/ritonavir among COVID-19 community, highly vaccinated patients with high risk for severe disease: Evidence that both antivirals reduce the risk for disease progression and death
Authors: Paraskevis D. , Gkova M. , Mellou K. , Gerolymatos G. , Psalida P. , Gkolfinopoulou K. , Kostaki E.G. , Loukides S. , Kotanidou A. , Skoutelis A. , Thiraios E. , Saroglou G. , Zografopoulos D. , Mossialos E. , Zaoutis T. , Gaga M. , Tsiodras S. , Antoniadou A. 
Published: February 2023

AbstractBesides the significant benefits of vaccination against COVID-19, the risk of severe disease and death from COVID-19 among highly vulnerable populations remains of concern. Implementation of oral antiviral treatment has shown significant benefits for outpatients with high risk for severe disease, however, their effectiveness remains to be evaluated in real-life settings and in the presence of new Omicron subvariants. We aimed to investigate the effectiveness of molnupiravir and nirmatrelvir/ritonavir using a retrospective cohort design with outcomes hospital admission and death from COVID-19, in Greece. The effectiveness of each drug was estimated through a comparison of the antiviral’s recipients with an age-matched control group of non-recipients, adjusted for age, previous SARS-CoV-2 infection, vaccination status, and vaccination recency. Our analysis showed that molnupiravir significantly reduced the risk for hospitalization (OR = 0.40, p < 0.001) and death from COVID-19 (OR = 0.31, p < 0.001), with the effect being more intense among elderly patients (≥75 years old). The effectiveness was higher among those with full adherence. Nirmatrelvir/ritonavir was found also to significantly reduce the risk of hospital admission (OR = 0.31, p < 0.001) and death (OR = 0.28, p < 0.001) and, similarly to molnupiravir, effectiveness was stronger among elderly patients and those with the highest levels of adherence. Analysis of the relative effectiveness of nirmatrelvir/ritonavir versus molnupiravir suggested that nirmatrelvir/ritonavir was associated with a reduced risk for hospital admission (OR = 0.58, p < 0.001) compared to molnupiravir, adjusted for age, previous SARS-CoV-2 infection, vaccination status, and co-morbidities. Our real-world study provides evidence about the reduced risk of hospitalization and death in highly vaccinated patients with a high risk for severe disease in Greece. These findings highlight that although the hospitalization and mortality risk has been reduced mainly due to vaccination and the emergence of Omicron variants, antivirals provide significant additional benefits in highly vulnerable patients and therefore their use is documented and strongly indicated.
Omics Analysis Unveils the Pathway Involved in the Purple Coloration in Tomato Seedling and Fruits
Authors: He Rui , Liu Kaizhe , Zhang Shuchang , Ju Jun , Hu Youzhi , Li Yamin , Liu Xiaojun , Liu Houcheng 
Published: February 2023

AbstractThe purple tomato variety ‘Indigo Rose’(InR) is favored due to its bright appearance and abundant anthocyanins.SlHY5is associated with anthocyanin biosynthesis in ‘Indigo Rose’ plants. However, residual anthocyanins still present inSlhy5seedlings and fruit peel indicated there was an anthocyanin induction pathway that is independent of HY5 in plants. The molecular mechanism of color formation in ‘Indigo Rose’ andSlhy5mutants is unclear. In this study, we performed omics analysis to clarify the regulatory network underlying coloration in seedling and fruit peel of ‘Indigo Rose’ andSlhy5mutant. Results showed that the total amount of anthocyanins in both seedling and fruit of InR were significantly higher than those inSlhy5mutant and most genes associated with anthocyanin biosynthesis exhibited higher expression levels in InR, suggesting thatSlHY5play pivotal roles in flavonoid biosynthesis both in tomato seedlings and fruit. Yeast two-hybrid (Y2H) results revealed that SlBBX24 physically interacts with SlAN2-like and SlAN2, while SlWRKY44 could interact with SlAN11 protein. Unexpectedly, both SlPIF1 and SlPIF3 were found to interact with SlBBX24, SlAN1 and SlJAF13 by yeast two-hybrid assay. Suppression of SlBBX24 by virus-induced gene silencing (VIGS) retarded the purple coloration of the fruit peel, indicating an important role ofSlBBX24in the regulation of anthocyanin accumulation. These results deepen the understanding of purple color formation in tomato seedling and fruits in an HY5-dependent or independent manner via excavating the genes involved in anthocyanin biosynthesis based on omics analysis.
m6A regulates the stability of cellular transcripts required for efficient KSHV lytic replication
Authors: Manners Oliver , Baquero-Perez Belinda , Mottram Timothy J. , Yonchev Ivaylo D. , Trevelyan Christopher J. , Patterson Molly R. , Macdonald Andrew , Wilson Stuart A. , Aspden Julie L. , Whitehouse Adrian 
Published: February 2023

AbstractThe epitranscriptomic modificationN6-methyladenosine (m6A) is a ubiquitous feature of the mammalian transcriptome. It modulates mRNA fate and dynamics to exert regulatory control over numerous cellular processes and disease pathways, including viral infection. Kaposi’s sarcoma-associated herpesvirus (KSHV) reactivation from the latent phase leads to redistribution of m6A topology upon both viral and cellular mRNAs within infected cells. Here we investigate the role of m6A in cellular transcripts upregulated during KSHV lytic replication. Results show that m6A is crucial for the stability of theGPRC5AmRNA, whose expression is induced by the KSHV latent-lytic switch master regulator, the replication and transcription activator (RTA) protein. Moreover, we demonstrate that GPRC5A is essential for efficient KSHV lytic replication by directly regulating NFκB signalling. Overall, this work highlights the central importance of m6A in modulating cellular gene expression to influence viral infection.Author SummaryChemical modifications on mRNA, such as m6A, are functionally linked to all stages of mRNA metabolism and regulate a variety of biological processes. As such, m6A modification offers unique possibilities for viruses to modulate both viral and host gene expression. m6A has been identified on transcripts encoded by a wide range of viruses and studies to investigate m6A function have highlighted distinct roles in virus life cycles. In addition, cellular transcripts undergoing differential m6A status during infection may also be important for virus replication. In this study we investigate the impact of differential m6A modification in host transcripts during KSHV lytic replication, by identifying transcripts with altered methylation profiles between latent and lytic replication programmes. We show that increased m6A content in one of these cellular mRNAs,GPRC5A, enhances its stability and correlates with increased abundance during KSHV lytic replication. Moreover, the importance of GPRC5A is demonstrated by depletion studies, showing that GPRC5A enhances KSHV lytic replication by inhibiting cell signalling pathways.
Modulation of GPR133 (ADGRD1) Signaling by its Intracellular Interaction Partner Extended Synaptotagmin 1 (ESYT1)
Authors: Stephan Gabriele , Erdjument-Bromage Hediye , Liu Wenke , Frenster Joshua D. , Ravn-Boess Niklas , Bready Devin , Cai Julia , Fenyo David , Neubert Thomas , Placantonakis Dimitris G. 
Published: February 2023

SummaryGPR133 (ADGRD1) is an adhesion G protein-coupled receptor that signals through Gαs and is required for growth of glioblastoma (GBM), an aggressive brain malignancy. The regulation of GPR133 signaling is incompletely understood. Here, we use proximity biotinylation proteomics to identify ESYT1, a Ca2+-dependent mediator of endoplasmic reticulum-plasma membrane bridge formation, as an intracellular interactor of GPR133. ESYT1 knockdown or knockout increases GPR133 signaling, while its overexpression has the opposite effect, without altering GPR133 levels in the plasma membrane. The GPR133-ESYT1 interaction requires the Ca2+-sensing C2C domain of ESYT1. Thapsigargin-mediated increases in cytosolic Ca2+relieve signaling-suppressive effects of ESYT1 by promoting ESYT1-GPR133 dissociation. ESYT1 knockdown or knockout in GBM impairs tumor growthin vitro, suggesting functions of ESYT1 beyond the interaction with GPR133. Our findings suggest a novel mechanism for modulation of GPR133 signaling by increased cytosolic Ca2+, which reduces the signaling-suppressive interaction between GPR133 and ESYT1 to raise cAMP levels.
Self-correction, control and accountability in the ancient Melaka Kingdom (1401–1511 AD)
Authors: Mustafa Hasri , Ibrahim Mohd Ikhwan 
Published: February 2023

PurposeThe purpose of this paper is to study the governance structure in the ancient Melaka Kingdom (1401–1511 AD) using historical Hukum Kanun Melaka (the Land Law) and Undang-Undang Laut Melaka (the Maritime Law). The focus is on self-correction, control and accountability that were used to preserve the peace and well-being of society and the overall harmony of the community during the period.Design/methodology/approachThe study employs close readings to discover and identify implicit formal and thematic elements of the texts into a meaningful enactment. The study is based on historical archival research at the National Archives of Malaysia and at the National Library of Malaysia.FindingsThough classical, the underlying accounting practices were shown to consummate in an articulated model of measurement activities based on specific proportion of gold in tahil measurement, used for slaves, free men and stolen animal and property value. Controls were established through punishment and penalty. Accountability functioned in different levels and degrees hierarchically and horizontally.Research limitations/implicationsThe study excludes the improved sections of the laws that are based on the Islamic perspective. The discussion is limited to the indigenous adat sections of laws only although the sections may inseparable with the Hindu/Buddhist tradition.Originality/valueA study of these classical laws would be a reference for accounting publication in the Malay world which has been stationed in the gallery for many years, awaiting discovery.
Joint modeling method of question intent detection and slot filling for domain-oriented question answering system
Authors: Wang Huiyong , Yang Ding , Guo Liang , Zhang Xiaoming 
Published: February 2023

PurposeIntent detection and slot filling are two important tasks in question comprehension of a question answering system. This study aims to build a joint task model with some generalization ability and benchmark its performance over other neural network models mentioned in this paper.Design/methodology/approachThis study used a deep-learning-based approach for the joint modeling of question intent detection and slot filling. Meanwhile, the internal cell structure of the long short-term memory (LSTM) network was improved. Furthermore, the dataset Computer Science Literature Question (CSLQ) was constructed based on the Science and Technology Knowledge Graph. The datasets Airline Travel Information Systems, Snips (a natural language processing dataset of the consumer intent engine collected by Snips) and CSLQ were used for the empirical analysis. The accuracy of intent detection and F1 score of slot filling, as well as the semantic accuracy of sentences, were compared for several models.FindingsThe results showed that the proposed model outperformed all other benchmark methods, especially for the CSLQ dataset. This proves that the design of this study improved the comprehensive performance and generalization ability of the model to some extent.Originality/valueThis study contributes to the understanding of question sentences in a specific domain. LSTM was improved, and a computer literature domain dataset was constructed herein. This will lay the data and model foundation for the future construction of a computer literature question answering system.
Motivational cultural intelligence and well-being in cross-cultural workplaces: a study of migrant workers in Taiwan
Authors: Yang Conna 
Published: February 2023

PurposeThis study sought to advance understandings of migrant worker labor outcomes by examining (1) the relationship between migrant employees’ motivational cultural intelligence (CQ) and employee well-being and (2) whether voice behavior at work mediates this relationship.Design/methodology/approachWorking with leader–member exchange (LMX) theory and conservation of resources theory, the author proposed a multiple mediation model to explain the relationship between motivational CQ and employee outcomes and how employee voice may mediate this relationship. LMX and voice behavior were tested for the mediating effects in a cross-cultural context. To test the model, a questionnaire was conducted with Vietnamese migrants working in Taiwan (343 valid responses were collected). The results were analyzed using regression and bootstrapping.FindingsHigher motivational CQ was associated with higher levels of work engagement and lower levels of job burnout. Strong employee voice mediated this relationship: high motivational CQ enabled workers to learn cultural nuances that helped them speak up in appropriate ways (in part by building strong relationships with leaders), which positively influenced work engagement and job burnout.Originality/valueThis study is one of the first to clarify and contribute to the research domain of cross-cultural management and motivational CQ among Vietnamese migrant workers living in Asian cultures. Past studies regarding CQ have seldom studied Southeast Asian migrant workers and the impact of motivational CQ on job burnout and work engagement. This study fills this gap and provides empirical evidence that may prove helpful for international human resources and organizational leaders.
The impact of COVID-19 restrictions on audit fees and audit delay: evidence from auditor local offices
Authors: Harjoto Maretno Agus , Laksmana Indrarini 
Published: February 2023

Purpose
This study aims to examine the impact of COVID-19 public health restrictions on audit fees and audit delay at the auditor local office level.

Design/methodology/approach
The authors take advantage of the availability of the state-by-state lockdown data to measure the degree of public health restrictions in auditor office locations. Using multivariate regression analysis, this study empirically investigates the impact of the length of lockdown in auditors’ office locations on audit fees and audit delay. The authors also examine whether office-level characteristics (i.e. office size and office-level client importance) moderate the association between the length of statewide lockdown and both audit fees and audit delay.

Findings
The authors find that a longer lockdown in auditors’ office locations is associated with higher audit fees and longer audit delay. The increase in audit fees and audit delay due to lockdown is higher for clients of larger local offices than those of smaller offices. In contrast, the positive impact of lockdown on audit fees and audit delay is less for more economically significant clients of an auditor office than that for less significant clients. Smaller clients are more likely to bear the higher cost of audits and experience longer audit delay during the pandemic.

Originality/value
The results suggest that COVID-19 restrictions have forced auditors to change the nature, scope and timing of their tests, resulting in higher audit fees and longer delays in completing audit engagements. Beyond the main effect of lockdowns on audit fees and audit delay, the study finds evidence of the moderating effect of auditor office size and office-level client importance, providing some insights on how auditor local offices cope with COVID-19 restrictions.