Axial Growth and Myopia Progression After Discontinuing Soft Multifocal Contact Lens Wear
Authors: Berntsen David A. , Tićak Anita , Orr Danielle J. , Giannoni Amber Gaume , Sinnott Loraine T. , Mutti Donald O. , Jones-Jordan Lisa A. , Walline Jeffrey J. ,   Bifocal Lenses in Nearsighted Kids (BLINK) Study Group, Everett Donald F. , Le Jimmy , Shaw Kimberly J. , Jones Jenny H. , Dougherty Bradley E. , Boatman Mora A. , Robich Matthew L. , Wessel Pamela S. , Mitchell G. Lynn , Cardenas Laura , Schulle Krystal L. , Retnasothie Dashaini V. , Walker Maria K. , Chandler Moriah A. , Nguyen Mylan T. , Hair Lea A. , Nti Augustine N. , Assaad Justina R. , Tomiyama Erin S. , Myers Jill A. , Nixon Alex D. , Bickle Katherine M. , Pierce Gilbert E. , Reuter Kathleen S. , Gardner Dustin J. , Kowalski Matthew , Morrison Ann , Fenton Rachel L. , Holbrook Janet T. , Gwiazda Jane , Edrington Timothy B. , Jackson John Mark , Joslin Charlotte E. 
Published: January 2025

ImportanceFor myopia control to be beneficial, it would be important that the benefit of treatment (slowed eye growth) is not lost because of faster than normal growth (rebound) after discontinuing treatment.ObjectiveTo determine whether there is a loss of treatment effect (rebound) after discontinuing soft multifocal contact lenses in children with myopia.Design, Setting, and ParticipantsThe Bifocal Lenses in Nearsighted Kids 2 (BLINK2) cohort study involved children with myopia (aged 11-17 years at BLINK2 baseline) who completed the BLINK Study randomized clinical trial. Enrollment was from September 2019 through January 2021; follow-up was completed in January 2024. In the BLINK2 Study, all children wore high-add (+2.50 diopter [D]) multifocal soft contact lenses for 2 years and single-vision soft contact lenses during the third year to determine if rebound occurred.ExposureHigh-add multifocal soft contact lenses and single-vision soft contact lenses.Main Outcomes and MeasuresEye length (optical biometry) and refractive error (cycloplegic autorefraction) were measured annually.ResultsOf 248 participants enrolled in BLINK2, 235 completed the study. The median age at the baseline visit was 15 years (range, 11-17 years); 146 participants (59%) were female, and 102 (41%) were male. At baseline for BLINK2, mean (SD) axial length and spherical equivalent refractive error were 25.2 (0.9) mm and −3.40 (1.40) D, respectively. After participants switched from multifocal to single-vision contact lenses, axial elongation increased by 0.03 mm per year (95% CI, 0.01 to 0.05) regardless of their original BLINK treatment assignment (P = .81). There was also an increase in myopia progression after switching to single-vision lenses of −0.17 D per year (95% CI, −0.22 to −0.12) that did not depend on the original BLINK treatment assignment (P = .57). There continued to be a difference in axial length and refractive error throughout BLINK2 based on the BLINK Study treatment assignment with the original high-add group having shorter eyes and less myopia than the original medium-add (+1.50 D) and single-vision groups.Conclusions and RelevanceThe BLINK2 Study found no evidence of a loss of treatment effect after discontinuing multifocal contact lenses in older teenagers. These data suggest eye growth and myopia progression returned to faster but age-expected rates and support continuing multifocal lenses until cessation of elongation and progression.