bluuebunny/crossref_metadata_2025_split huggingface dataset:
Application of Early Continuous Flushing and Drainage with Self- Made Double-Lumen Drainage Tube in Pancreaticoduodenectomy
Authors: Zhang Yi , Lu Yu-Hang , Chen Yi , Huang Ming-Wen 
Published: January 2025

Abstract

Background and Objectives
The incidence of complications following pancreaticoduodenectomy (PD) is notably high. Early postoperative abdominal lavage has been suggested as a potential intervention to reduce these complications. This study explores the safety and efficacy of a self-made double-lumen drainage tube by comparing the incidence of complications after PD using different drainage tubes.
Methods
A retrospective study was conducted to analyze the clinical data of patients who underwent PD at our medical center from 2019 to 2022.
Results
Pancreatic fistula-related bleeding occurred in 2 cases (3.1%) in the experimental group and 37 cases (11.3%) in the control group, with the experimental group showing a significantly lower incidence of pancreatic fistula-related bleeding (P = 0.045). Abdominal infection occurred in 3 cases (4.7%) in the experimental group and 51 cases (15.6%) in the control group, with the experimental group having a significantly lower incidence of abdominal infection (P = 0.020). The length of hospital stay was significantly shorter in the experimental group (21.73 ± 2.82 days) compared to the control group (23.69 ± 5.37 days) (P = 0.005).
Conclusion
Early use of continuous abdominal lavage with a self-made dual-lumen drainage tube following PD is safe, feasible, and effective.
Exploring Biases Related to the Use of Large Language Models in a Multilingual Depression Corpus
Authors: Pérez-Toro Paula Andrea , Dineley Judith , Iniesta Raquel , Zhang Yuezhou , Matcham Faith , Siddi Sara , Lamers Femke , Haro Josep Maria , Penninx Brenda W.J.H. , Folarin Amos A. , Arias-Vergara Tomás , Orozco-Arroyave Juan Rafael , Nöth Elmar , Maier Andreas , Wykes Til , Vairavan Srinivasan , Dobson Richard , Narayan Vaibhav A. , Hotopf Matthew , Cummins Nicholas , Consortium The RADAR-CNS 
Published: January 2025

Abstract

Recent advancements in Large Language Models (LLMs) present promising opportunities for applying these technologies to aid the detection and monitoring of Major Depression Disorder (MDD). However, demographic biases in LLMs may present challenges in the extraction of key information. This study evaluates commonly used LLMs in the speech health literature, across a cohort comprised of English, Spanish, and Dutch speakers with recurrent MDD to observe the effects of different demographic imbalances. Results indicate demographics indeed influence model performance. Gender showed variable impacts across models, with age presenting more pronounced differences. Model performance also varied across language. This study emphasizes the necessity of incorporating demographic-aware models in health-related analyses. It raises awareness of the biases that may affect their application in mental health and suggests further research on methods to mitigate these biases and enhance model generalization.
Overview of the carrying capacity for shrimp farming sustainability: the case of Bangka Island, Indonesia
Authors: Mardyani Yeyen , Nirmala Kukuh , Bidayani Endang , Syarif Ahmad Fahrul , Nugraha Mohammad Agung , Setiawan Fahri , Riskiana Refa , Febrianto Arief 
Published: January 2025

Abstract

High investment interest in white leg shrimp (Litopaneus vannamei) in the Bangka Belitung Islands Province has been observed in the increasing number of shrimp ponds in the last few years. The management of the rapid growth of shrimp ponds must be environmentally sound to maintain the sustainability of shrimp farming and ensure economic benefits without neglecting ecosystem sustainability. The study was conducted from March to November 2022 in Bangka Coastal, Indonesia. This study aims to assess the carrying capacity of the waters and the sustainability of shrimp farming on the Bangka coast through a mass balance model. The physical aspects of water quality were measured in situ and analyzed in the laboratory using various parameters, including temperature, salinity, dissolved oxygen (DO), pH, nitrite, ammonia, phosphate, biochemical oxygen demand (BOD), and chemical oxygen demand (COD). The results revealed that the quality of the shrimp and all the water parameters were within the threshold value, except for ammonia, which was above the threshold. The mangrove coverage density of the shrimp pond area varies: it is considered low to moderate in the Parittiga coastal region of West Bangka, while in the Tukak Sadai coastal area of South Bangka, it ranges from moderate to high. The average shrimp production on the Parittiga coast reaches 40–69 metric tons year-1, whereas that on the Tukak Sadai coast reaches 50–180 metric tons year-1. Based on mass balance calculation, the potential areas available for developing shrimp farming on the Parittiga coast are estimated 86,60–175,39 hectares and 27,65–45,05 hectares on the Tukak Sadai coast. Consequently, it is necessary to monitor and regulate waste disposal and the installation of wastewater treatment plants (WWTPs) at each shrimp pond, as well as to enhance the capacity of these WWTPs to reduce waste by 80%.
Factors associated with SARS-CoV-2 infection amongst Health Workers in Bamako, Mali: a cohort study from November 2021 to February 2023
Authors: Konaté Drissa , Balam Saidou , Dolo Housseini , Koné Amadou , Traoré Bourama , Kané Fousseyni , Incandela Nathan C , Diallo Dramane , Traoré Abdouramane , Kanté Salimata , Sidibé Mariam , Keita Bourama , Coulibaly Aminatou , Kassé Fatoumata , Tangara Karamoko , Maiga Issoufi Y , Guindo Merepen dite Agnès , Denou Larissa , Konaké Mama Sy , Traoré Mariétou , Dicko Abdoul RA , Keita Naman , Koné Diakaridia , Malle Korotoumou , Coulibaly Yaya Ibrahim , Faye Ousmane , Diakité Mahamadou , Doumbia Seydou 
Published: January 2025

Abstract

Background. Health workers (HWs) are at high risk of SARS-CoV-2 infection due to their frontline role and considered as priority group for COVID-19 vaccination. This study aimed to estimate SARS-CoV-2 infection and COVID-19 incidence rates and identify the risk factors among HWs in Mali to strengthen prevention measures.
Method. A cohort study of 1098 HWs was conducted from November 2021 to February 2023, in six health centers and two university hospitals of Bamako. Sociodemographic and clinical data, nasopharyngeal swabs were collected to determine asymptomatic SARS-CoV-2 infection rate during the cross-sectional surveys. Self-reported COVID-19 cases were collected during biweekly follow-ups. REDCap was used for data management. Mixed-effects Cox regression models and multivariate logistic regression were used to identify the risk factors for SARS-CoV-2 infection.
Results. Amongst 1098 HWs, 34.7% were nurses, 8.2% have had contact with COVID-19 patients, and 18% with COVID-19 samples. A significant change in the rate of SARS-CoV-2 infection (asymptomatic infection) was observed between November 2021 (3.4%), February 2022 (1.3%) and February 2023 (4.8%, p = 0.0001). SARS-CoV-2 21I (36.7%) and 21L (8.2%) Delta variants were observed mainly in November 2021 giving place to Omicron over time. The distribution of SARS-CoV-2 variants was similar in vaccinated and unvaccinated health workers (p = 0.716). Absence of anti-N antibodies (HR=3.98 95%CI, 2.23-7.12), contact with COVID-19 patients (HR=3.85 95%CI, 2.00-7.44]), use of public transport (HR=2.20 95%CI, 1.05-4.61) and participation in public events (HR=7.93 95%CI, 1.03-60.1) were associated with a higher risk COVID-19 confirmed cases (symptomatic SARS-CoV-2 infection).
Conclusion. Results show a high rate of SARS-CoV-2 infection in February 2023, and the risk factors were both in work and community settings.
Combined reconstruction of the middle hepatic vein in the right lobe split liver transplantation
Authors: Lin Zhengwei , Feng Fei , Yu Qi , Ye Yingpeng , Yang Yong , Zhu Hongda , Lu Caide , Fang Jiongze 
Published: January 2025

Abstract

Purpose
There are few studies on the reconstruction of the middle hepatic vein (MHV) in split liver transplantation (SLT) using right lobe grafts. This study aimed to compare the outcomes of patients with MHV combined with right hepatic vein (RHV) reconstruction and those with separate reconstruction.
Methods
Clinical data of 114 patients who underwent SLT from March 2021 to December 2023 were retrospectively collected. We analyzed and compared the postoperative outcomes and reconstructed MHV patency between different modalities of MHV reconstruction in the right lobe SLT.
Results
Forty-five right lobe grafts were reconstructed with the MHV and were divided into two groups according to the type of reconstruction. Group 1 (n = 19) received separate reconstruction, while Group 2 (n = 26) received combined reconstruction. The duration of warm ischemia in Group 2 was significantly less than that in Group 1 (47.9 ± 7.8 vs. 59.7 ± 15.6 min, P = 0.002), and the ICU hospitalization time was significantly less in Group 2 than in Group 1 (2 vs. 3 days, P = 0.022). The rate of complete patency of the reconstructed MHV at 30 days postoperatively was higher in Group 2 than in Group 1 (96.2% vs. 68.4%, P = 0.031). The rates of postoperative complications were comparable between the two groups.
Conclusion
Combined reconstruction of the MHV and RHV in SLT improves the rate of complete patency of the reconstructed MHV, reduces warm ischemia time, and shortens the length of ICU stay.
Quiet Time and Noise-Mitigation Strategies in a Long-Term Care Facilities
Authors: Massarweh Alaa Zuahir , Bakhit Refa Hanish B Z , MOHD NAGWA AHMED BABIKIR , Zaharan Mohammad , Icic Novica 
Published: January 2025

Abstract

Purpose: this research was conducted to examine the significant impact of quiet time and noise-mitigation strategies on reducing noise pollution in the long-term care facility.
Design/methodology/approach: in this quality improvement project, noise intensity within the unit was recorded before rolling out the intervention program. Noise intensity was recorded for 2 hours in the morning and evening shifts and for 6 hours during the night. An average noise intensity was noted for the one week of measurement before the intervention program consisting of quiet time and noise-mitigation strategies. The mitigation approach through the PDSA model involved educating the staff, patients and patients’ family members about mitigation strategies. Staff compliance and satisfaction were assessed using a survey, and noise intensity was measured using the Yacker tracker and recorded between November 2021 and April, 2022.
Findings: at the end of the quality improvement project, the noise intensity within the long term care unit declined from 88dB to 35dB which is within the recommendation of the World Health Organization. The decline was statistically significant (t(12) = 160.103, p = .000). Staff and patients’ satisfaction with noise within the unit also increased from 35% to 78% between, and the improvement was statistically significant at 95% confidence interval (p<.001). Moreover, compliance with the noise reduction behaviors improved significantly over the period of the program (p<.001).
Originality: this research observed the significance of combining education and behavior change methods aligned to the PDSA model to reduce noise levels in the long term care facility.
Analysis of YouTube Videos on Assisted Reproductive Techniques
Authors: Demirtas Selim , Gördük Mehmet Nuri 
Published: January 2025

Abstract

Background
Assisted reproductive techniques (ART) have made significant progress in infertility treatment and have found a wide range of applications with various methods, especially in vitro fertilisation. Today, digital platforms such as YouTube have become an important resource for individuals seeking information about ART. However, uncertainties about the reliability and quality of this content pose a potential risk for viewers. This study aims to assess the quality and reliability of ART-related videos on YouTube.
Methods
76 videos were analyzed by applying elimination criteria from 350 videos uploaded between October 1, 2014 and October 1, 2024. These videos were obtained through YouTube Data API v3 by searching seven different terms related to in vitro fertilization and infertility. In addition to descriptive statistics on video features, the Global Quality Scale (GQS), Modified DISCERN, JAMA and UTvAC scales were applied to evaluate the quality of the videos. Additionally, sentiment analysis was conducted on the comments of the videos.
Results
It was determined that the majority of the analyzed videos were at medium quality level. While the JAMA scores indicate that most of the videos are of low quality, the GQS and Modified DISCERN scores suggest that most videos fall within the medium quality range. According to UTvAC, most videos are just below the high-quality limit. The majority of videos were uploaded by doctor-independent influencers (32.9%), non-governmental organizations (25.0%), and news/media (21.1%) channels. The positive comment percentage was found to be 28%, indicating that the videos were generally poorly appreciated by viewers.
Conclusion
This study revealed that the information quality and reliability of ART videos on YouTube are generally moderate. It is recommended that viewers should adopt a critical approach and turn to reliable sources when evaluating content on ART. The findings of the study show that there is a significant need for improvements in digital health communication and educational content production.
Green Synthesis, Characterization, In Silico Molecular Docking and Biological Evaluation of Imidazolylchalcones as Promising Fungicide/s and Nematicide/s
Authors: Kumar Rakesh , Kaushik Parshant , Tripathi Kailashpati , Godara Rajni , Misra Sameer Ranjan , Kumar Vijay , Mondal Patha Chandra , Jeetram Jeetram , Pankaj Pankaj , Rana Virendra Singh , Shanmugam V. , Khatri Dilip , Shakil Najam Akhtar 
Published: January 2025

Abstract

Chalcones and their derivatives have garnered attention due to their broad-spectrum biological activities. In this study a series of 15 imidazolylchalcone derivatives were synthesized by Claisen-Schmidt condensation of benzaldehydes and 4-(Imidazol-1-yl) acetophenone through ultrasonication as green synthesis. These compounds were characterized by various spectroscopic techniques, namely 1H-NMR, 13C-NMR and LC-HRMS. These molecules were evaluated for their fungicidal activity against Rhizoctonia solani & Fusarium oxysporum and nematicidal activity against Meloidogyne incognita. The result revealed that compound IC-8 ((E)-1-(4-(1 H-imidazole-1-yl) phenyl)-3-(4-benzyloxy)phenyl)prop-2-en-1-one) exhibited the most potent fungicidal activity, with an ED50 value of 0.69 µg mL− 1, significantly lower than the ED50 value (3.57 µg mL− 1) of commercially available hexaconazole 5% SC fungicide against R. solani, while IC-4 ((E)-1-(4-(1 H-imidazole-1-yl) phenyl)-3-(2-bromophenyl) prop-2-en-1-one; ED50 = 119.22 µg mL− 1) showed highest activity against F. oxysporum as compared with the positive control Carbendazim 50% Wettable powder (WP; ED50 = 9.01 µg mL− 1). The compound IC-6 ((E)-1-(4-(1 H-imidazole-1-yl) phenyl)-3-(3-nitrophenyl) prop-2-en-1-one; LC50 = 33.62 µg mL− 1) was found to be most active against M. incognita (LC50 = 31.25 µg mL− 1) after 24 h of inoculation but lesser active than positive control Velum Prime 34.48% SC (Fluopyrum; LC50 = 3.46 µg mL− 1). Molecular docking studies of imidazolylchalcone derivative-based structural isomers were carried out against cutinase of fungi and acetylcholinesterase (AChE) enzyme of nematode as primary targets. The binding potential of target compounds was investigated by using AutoDock Vina. Ligands were ranked according to their binding affinities via BIOVIA Discovery Studio. Ligand-protein interactions strengthened results of biological evaluation that predicted compound IC-8 as the most active with highest binding energy (-8.5 kcal mol− 1) against R. solani, IC-4 (-8.0 kcal mol− 1) against cutinase of F. oxysporum and IC-6 (-9.7 kcal mol− 1) with acetylcholinesterase (AChE) of M. incognita.
Theoretical investigation on heat transfer rate of hydromagnetic transformer oil based multiphase fluid: Comprehensive modeling and computational study
Authors: Nazeer Mubbashar 
Published: January 2025

Abstract

Motivation and objective: The main objective of this research is to investigate the thermal analysis of the magneto two-phase flow of Prandtl fluid with the suspension of silver and hafnium nanoparticles through inclined walls of the channel. The momentum equations are modified under the addition of body forces to consider the impact of magnetic and gravitational forces. The heat equation is also updated with the addition of the heat flux term to capture the thermal radiation effects.
Methodology: The two-phase model is developed in terms of continuity, momentum, and heat equations of fluid and particle phases and uses dimensionless variables to simplify the system of equations. The dimensionless form of equations is solved by using the regular perturbation method in which the second Prandtl fluid parameter is taken as a perturbation parameter and produces the analytical solution. The graphical results revealed many physical aspects under the physical parameters in which the first and second Prandtl fluid parameters diminish the fluid and particle phase velocity distribution.
Outcomes: The suspension of hafnium particles in the base fluid provides more heat to the system as compared to silver nanoparticles. The particle phase velocity distribution is much greater than the fluid phase against all parameters of the study. The magnetic force has an inverse relation with the velocity and thermal profiles of both phases. The two-phase Prandtl fluid model provides 55 %more heat transfer as compared to the single-phase Prandtl fluid model. The two-phase Prandtl fluid model gives 29% greater heat transfer to the system as compared to the phase Newtonian fluid model.
Significance of the study: The current study will help to optimize the industrial thermal management process and to design efficient cooling systems in electronic devices, and in polymer and food processing.
Originality: The topic discussed in this study is new and has not been deliberated before.
Stochastic resonance in Schmitt trigger and its application towards weak signal detection
Authors: Kim Yoonkang , Seo Donghyuk 
Published: January 2025

Abstract

This study explores stochastic resonance (SR) in a Schmitt trigger circuit and its application to weak signal detection. SR, a phenomenon where noise synchronizes with weak signals to enhance detectability, was demonstrated using a custom-designed bi-stable Schmitt trigger system. The circuit's bi-stability was validated through hysteresis curve analysis, confirming its suitability for SR studies. Experimental results revealed SR behavior by analyzing signal-to-noise ratio (SNR) responses to noise amplitude variations. Detection experiments were conducted to determine frequency and amplitude of damping sinusoidal pulses. Frequency detection proved effective, albeit with limitations at low frequencies, while amplitude detection faced challenges due to mathematical complexities. Nonetheless, the study highlights SR's potential for weak signal detection, with proposed enhancements to improve detection accuracy. This work underscores the adaptability of classical SR principles to practical detection systems and suggests future applications in advanced detection technologies, including quantum systems.
Bavachalcone targets TFRC and sensitizes gemcitabine to affect bladder cancer progression through the iron-dependent ATR-CHEK1-E2F1 signaling pathway
Authors: Zhang Zihao , Yuan Chenyue , Ge Qintao , Liu Wangrui , Xu Meng , Wang Mengfei , Feng Tao , Wang Yue , Zheng Shengfeng , Wang Zhongyuan , zhang Wei , Tian Xi , Huang Wei , Chen Ziqi , Tu Chao , Zhang Hailiang , Shi Guohai , Cao Dalong , Shen Yijun , Wang ZiLiang , Ye DingWei 
Published: January 2025

Abstract

Gemcitabine resistance is a critical factor contributing to the recurrence and progression of bladder cancer. In this study, we utilized high-throughput drug screening and bladder cancer organoid models to identify Bavachalcone (Bava) as a sensitizing agent for gemcitabine, thereby inhibiting the progression of bladder cancer. Bava targets transferrin receptor (TFRC) and epidermal growth factor receptor (EGFR), competitively binding to TFRC with transferrin (Tf), which reduces the influx of iron ions and the activity of mitochondrial respiratory chain complexes. Concurrently, Bava inhibits the phosphorylation of TFRC at tyrosine 20 (Y20) by blocking EGFR phosphorylation, thereby stabilizing TFRC on the cell membrane. The combination of Bava and gemcitabine effectively inhibits the repair of DNA damage induced by gemcitabine. Additionally, Bava suppresses the iron-induced ATR-CHEK1-E2F1 signaling pathway and decreases the expression of RRM1, further sensitizing cells to gemcitabine. Studies utilizing patient-derived xenografts of bladder cancer have demonstrated that the Bava-gemcitabine combination significantly inhibits tumor progression. Correlating with clinical data, we found that TFRC and RRM1 may serve as markers of poor prognosis in bladder cancer. In summary, our research has identified specific Chinese medicine monomers that sensitize cells to gemcitabine, elucidated their direct action targets, and highlighted the role of iron ions in tumor development. This work also paves the way for novel drug design strategies that target TFRC to inhibit iron ion influx and mitigate bladder cancer progression.
Ginsenoside Rg3 in Cancer Research: Current Trends and Future Prospects - A Review
Authors: Tanko Auwal Ibrahim , Hosawi Salman , Moglad Ehssan , Afzal Muhammad , Ghaboura Nehmat , Alzareaa Sami I. , Osman Ahmed , Nadeem Muhammad Shahid , Kazmi Imran 
Published: January 2025

Abstract:
Cancer is one of the most devastating illnesses in the world, impacting millions
of individuals every year. Despite various therapies, the final effect is unsatisfactory.
Chemotherapy currently dominates as the primary option of treatment. However, its
severe adverse effects, limited efficacy, and resistance to drugs undermine its potential.
Growing evidence suggests that ginsenoside Rg3, a natural compound obtained from the
ginseng plant (Panax ginseng), holds significant promise in cancer therapy. Its proposed
mechanisms primarily involve the enhancement of immunity, retardation of cancer cellular
proliferation and metastasis, triggering apoptosis, angiogenesis, epigenetic modification,
and Regulation of transition of epithelial mesenchyma (EMT) and miRNAs/lncRNA.
Furthermore, Rg3-ginsenoside potentiates the effectiveness of conventional treatments
of cancer and reduces the adverse effects through synergistic interactions.
Ginsenoside Rg3's present status in cancer research is thoroughly reviewed in this article,
shedding light on its intricate mechanisms and potential to revolutionize cancer therapy
through combinatorial and nano-based targeted therapy.