bluuebunny/crossref_metadata_2025_split huggingface dataset:
Large epigenome-wide association study identifies multiple novel differentially methylated CpG sites associated with suicidal thoughts and behaviors in veterans
Authors: Kimbrel Nathan A. , Garrett Melanie E. , Evans Mariah K. , Mellows Clara , Dennis Michelle F. , Hair Lauren P. , Hauser Michael A. ,   the VA Mid-Atlantic MIRECC Workgroup, Ashley-Koch Allison E. , Beckham Jean C. 
Published: May 2023

IntroductionThe U.S. suicide mortality rate has steadily increased during the past two decades, particularly among military veterans; however, the epigenetic basis of suicidal thoughts and behaviors (STB) remains largely unknown.MethodsTo address this issue, we conducted an epigenome-wide association study of DNA methylation (DNAm) of peripheral blood samples obtained from 2,712 U.S. military veterans.ResultsThree DNAm probes were significantly associated with suicide attempts, surpassing the multiple testing threshold (FDR q-value &lt;0.05), including cg13301722 on chromosome 7, which lies between the genes SLC4A2 and CDK5; cg04724646 in PDE3A; and cg04999352 in RARRES3. cg13301722 was also found to be differentially methylated in the cerebral cortex of suicide decedents in a publicly-available dataset (p = 0.03). Trait enrichment analysis revealed that the CpG sites most strongly associated with STB in the present sample were also associated with smoking, alcohol consumption, maternal smoking, and maternal alcohol consumption, whereas pathway enrichment analysis revealed significant associations with circadian rhythm, adherens junction, insulin secretion, and RAP-1 signaling, each of which was recently associated with suicide attempts in a large, independent genome-wide association study of suicide attempts of veterans.DiscussionTaken together, the present findings suggest that SLC4A2, CDK5, PDE3A, and RARRES3 may play a role in STB. CDK5, a member of the cyclin-dependent kinase family that is highly expressed in the brain and essential for learning and memory, appears to be a particularly promising candidate worthy of future study; however, additional work is still needed to replicate these finding in independent samples.
Effect of a telecare-based intervention on stress levels in informal caregivers of older adults: protocol for a randomized controlled trial
Authors: Wong Arkers Kwan Ching , Ng Nga Ping , Hui Vivian Chi Ching , Montayre Jed 
Published: May 2023

SignificanceDue to caregiving commitments, caregivers of older adults may not have the time to make use of the onsite community services available to them during the day. With the support of advanced technology, telecare could be a convenient and easily accessible channel for providing individualized caregiving advice to caregivers.ObjectiveThe aim of the study is to describe a research protocol that highlights the development of a telecare-based intervention program for reducing stress levels in informal caregivers of community-dwelling older adults.MethodsIt is a randomized controlled trial. The study is supported by two community centers. The study participants will be randomly assigned to either the telecare-based intervention group or the control group. The former will receive a 3-month program comprised of three components: online nurse case management supported by a health and social care team, an online resource center, and a discussion forum. The latter will receive the usual services that provided by the community centers. Data will be collected at two time points – pre-intervention (T1) and post-intervention (T2). The primary outcome is stress levels, while secondary outcomes include self-efficacy, depression levels, quality of life, and caregiving burden.DiscussionBesides taking care of one or more older adults, informal caregivers have to deal with work, chores, and take care of their children. This study will add valuable information to the knowledge gap on whether telecare-based interventions with the support of an integrated health-social team can alleviate the stress levels of informal caregivers of community-dwelling older adults. If successful, policymakers and healthcare professionals should consider incorporating telecare modalities in a primary health setting for informal caregivers to correspond with them, to relieve their caregiving stress and promote a healthy life.Clinical trial registrationhttps://www.clinicaltrials.gov/, NCT05636982.
An empirical study of the impact of generic drug competition on drug market prices in China
Authors: Yina Chen , Pengcheng Liu , Haomiao Nie , Yang Cao 
Published: May 2023

IntroductionGeneric substitution is encouraged to reduce pharmaceutical spending in China, and with incentive policies, the market size of the generic drug continues to rise. To find out how the generic competition affects drug price in this area, this study examines how the quantity of generic drug manufacturers can influence average drug price in the Chinese market.MethodsThis study uses a rigorous selection of drugs from the 2021 China’s National Reimbursement Drug List (NRDL), and uses drug-level fixed effects regressions to estimate the relationship between competition and price within each drug.ResultsWe note that drug prices decline with increasing competition in the Chinese market, but not in a perfectly linear manner, with marginal price declines decreasing after the fourth entrant and “rebounding” at subsequent entrants, especially the sixth.DiscussionThe findings suggest the importance of maintaining effective competition between suppliers to control prices, and that the government needs to further control generic pricing, especially for late entry generics, to ensure effective competition in the Chinese market.
Health-related quality of life in older women with injuries: a nationwide study
Authors: Kwak Yeunhee , Ahn Jung-Won 
Published: May 2023

ObjectivesThis study aims to describe the health-related quality of life (HRQoL) and influencing factors of older women who experienced injuries.MethodsThis study is a secondary analysis of data from 4,217 women aged 65 years or older sampled from the Korea National Health and Nutrition Examination Survey (KNHANES) (2016–2020) database. Two-way analysis of variance was used to analyze the data.ResultsThe mean HRQoL scores of older women with and without injuries were 0.81 ± 0.19 (n = 328) and 0.85 ± 0.17 (n = 3,889), respectively, which were significantly different (p &lt; 0.001). The results of multiple regression analysis revealed that working, physical activity, BMI, osteoarthritis, stress, and subjective health status significantly affected the HRQoL of older women with injuries, and the explanatory power of the model was 29%.ConclusionThe results of this study on factors affecting HRQoL can contribute to the understanding of the experience of older women with injuries and can be used as a reference to develop health promotion programs.
Increased risk of new-onset diabetes in patients with COVID-19: a systematic review and meta-analysis
Authors: Li Jiajun , Li Yapeng , Wang Zhenzhen , Liu Nanyang , He Lanye , Zhang Han 
Published: May 2023

BackgroundThere is growing evidence that patients with COVID-19 are at increased risk of new-onset diabetes. The limited preliminary studies do not provide strong evidence. To assess the association of the SARS-CoV-2 virus with new-onset diabetes and to characterize the population.MethodsSearch PubMed, Embase, Cochrane Library, and Web of Science electronic databases for a limited period from December 2019 to July 2022. Two independent reviewers conducted a thorough review of eligible articles and extracted relevant information. Pooled proportions, risk ratios (RR), and 95% confidence intervals (95% CI) indicated the incidence and risk ratios of events.ResultsThe incidence of new-onset diabetes and hyperglycemia in patients with COVID-19 was 5% (P &lt; 0.001) (3 and 30% for new-onset diabetes and hyperglycemia, respectively), with age, ethnicity, time of diagnosis, and study type all having an impact on the incidence (P &lt; 0.05). New-onset diabetes and hyperglycemia were 1.75 times higher in COVID-19 patients than in non-COVID-19 patients. In new-onset diabetes and hyperglycemia population, the percentage of men is 60% (40% for women), with a mortality rate of 17%. The proportion of new-onset diabetes and hyperglycemia after infection with COVID-19 was 25% in men and 14% in women.ConclusionsThe incidence and relative risk of new-onset diabetes and hyperglycemia are elevated after COVID-19 infection, especially in the early COVID-19 and male populations.Systemic review registrationPROSPERO registration no.: CRD42022382989 https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=382989.
Association of working hours and cumulative fatigue among Chinese primary health care professionals
Authors: Lu Yushi , Li Zhi , Chen Qingsong , Fan Yuting , Wang Jin , Ye Yonghao , Chen Yongqi , Zhong Tian , Wang Ling , Xiao Ying , Zhang Dongmei , Yu Xi 
Published: May 2023

IntroductionThe association between long working hours and cumulative fatigue is widely acknowledged in the literature. However, there are few studies on the mediating effect of working hours on cumulative fatigue using occupational stress as a mediating variable. The present study aimed at investigating the mediating role of occupational stress in the relationship between working hours and cumulative fatigue in a sample of 1,327 primary health care professionals.MethodsThe Core Occupational Stress Scale and the Workers’ Fatigue Accumulation Self-Diagnosis Scale were utilized in this study. The mediating effect of occupational stress was examined using hierarchical regression analysis and the Bootstrap test.ResultsWorking hours were positively associated with cumulative fatigue via occupational stress (p &lt; 0.01). Occupational stress was found to partially mediate the relationship between working hours and cumulative fatigue, with a mediating effect of 0.078 (95% CI: 0.043–0.115, p &lt; 0.01), and the percentage of occupational stress mediating effect was 28.3%.DiscussionWorking hours can be associated with cumulative fatigue either directly or indirectly via occupational stress. As a result, by reducing occupational stress, primary health care professionals may reduce the cumulative fatigue symptoms caused by long hours of work.
Feasibility of a pilot dyadic randomized controlled trial testing the effects of three behavioral interventions on older adults’ cognitive, physical and everyday function
Authors: Phillips Christine B. , McVey Ava , Tian Junyan , Stephan Abigail T. , Davis W. Bennett , Aflagah Erica L. , Ross Lesley A. 
Published: May 2023

Introduction: Maintaining functional abilities is critical for optimizing older adults’ well-being and independence. This randomized controlled trial (RCT) pilot examined the feasibility of testing the effects of three commercially available interventions on function-related outcomes in older adults. Methods: Pairs of community-dwelling older adults (N=55, Mage=71.4) were randomized to a 10-week intervention (cognitive-COG, physical-EX, combined exergame-EXCOG, or control-CON). Cognitive, physical, and everyday function were assessed at baseline, immediately post-intervention, and 6-months post-intervention. Feasibility was evaluated using recruitment, enrollment, training adherence, and retention metrics. Variability and patterns of change in functional outcomes were examined descriptively. Results: A total of 208 individuals were screened, with 26% subsequently randomized. Across training arms, 95% of training sessions were completed and 89% of participants were retained at immediate post-test. Variability in functional outcomes and patterns of change differed across study arms. Discussion: Results support a fully powered RCT, with several modifications to the pilot study design, to investigate short- and long-term training impacts.
An Online Survey of the Perceptions of Clinical and Non-Clinical Professionals on Healthcare for Non-Communicable Diseases and COVID-19 Measures During the Pandemic in Malaysia
Authors: Sureshkumar Sugitha , Mustapha Feisul , Yusoff Haironi , Mwangi Kibachio Joseph , Marcus Kailing , Kohlbrenner Bogomil , Issom David , Benissa Mohamed-Rida , Aebischer-Perone Sigiriya , Braha Nirit , Candela Egidio , Chhabra Kumar Gaurav , Desikachari B. R. , Dondi Arianna , Etchebehere Marina , Gathecha Gladwell , Kengne Andre Pascal , Missoni Eduardo , Palafox Benjamin , Pati Sanghamitra , Madhu Priyanka Paul , Peer Nasheeta , Quint Jennifer , Tabrizi Reza , Oris Michel , Beran David , Balabanova Dina , Etter Jean-Francois 
Published: May 2023

Objectives: This study assesses the opinions of health professionals in Malaysia on the disruption of non-communicable disease (NCD) services during the COVID-19 pandemic from March 2020 to January 2022.Methods: We conducted a cross-sectional online survey with 191 non-clinical public health workers and clinical health service workers in Malaysia from November 2021 to January 2022. Participants were recruited by the Malaysian Ministry of Health using major networks including key experts and practitioners. Secondary respondents were subsequently enrolled through snowballing.Results: The most notable issues raised by the survey participants relate to NCD service disruption, the redirection of NCD care resources, and NCD care being overburdened post-pandemic. Respondents also reported accounts of resilience and prompt reaction from the healthcare system, as well as calls for innovation.Conclusion: Most respondents perceived that the challenges arising from COVID-19 were mostly managed well by the healthcare system, which was able to provide the necessary services to NCD patients during this health emergency. However, the study identifies gaps in the health system response and preparedness capacity, and highlights solutions for strengthening NCD services.
Network pharmacology and molecular docking reveal the immunomodulatory mechanism of rhubarb peony decoction for the treatment of ulcerative colitis and irritable bowel syndrome
Authors: Zhai Leilei , Yang Weiming , Li Dianrong , Zhou Wei , Cui Min , Yao Ping 
Published: May 2023

Background: Ulcerative colitis (UC) and irritable bowel syndrome (IBS) share various similarities in clinical symptoms, pathogenesis, and treatment. UC concurrent IBS tends toward more severe symptoms and worse prognosis, and promising feasible therapies for the overlapping symptoms remains a challenge. Rhubarb peony decoction (RPD) is a well-known traditional Chinese medicine that has been widely applied in treating UC. RPD may exert extensive therapeutic effects on both IBS and UC. However, the common mechanism of its treatment remains unclear. We aimed to assess the potential pharmacological mechanism of RPD in the treatment of overlapping IBS and UC.Methods: The active components and targets of RPD were retrieved from ETCM, TCMSP, BATMAN-TCM, and TCM databases. The disease targets were screened by searching the DrugBank, OMIM, TTD, and PharmGKB databases. PPI network analysis was performed and visualized via the STRING platform and Cytoscape software. GO and KEGG enrichment analyses of the hub genes of RPD were predicted to elucidate the potential molecular mechanism. Subsequently, molecular docking was carried out to verify the combination of active compounds with core targets.Results: By integrating all targets of RPD and disease, a total of 31 bioactive ingredients were identified including quercetin, kaempferol, aloe-emodin, beta-sitosterol, and (+)-catechin, etc. JUN, TP53, MAPK1, RELA, MYC, and ESR1 were explored as potential therapeutic targets among 126 common drug-disease-related targets. They were enriched in the AGE-RAGE signaling pathway in diabetic complications, as well as the NF-kappa B signaling pathway and MAPK signaling pathway. Additionally, some active ingredients were identified as candidates for binding to the hub targets via molecular docking, further suggesting their anti-inflammatory and antioxidative properties.Conclusion: RPD may exert the overall treatment effect for UC and IBS overlap syndrome via the biological mechanism of “multi-ingredients, multi-targets, and multi-pathways” on inflammation, oxidative stress, immune, oncogenicity, and gut microbiota dysbiosis.
Genetic and Epigenetic Regulation of Drosophila Oocyte Determination
Authors: Cabrita Brigite , Martinho Rui Gonçalo 
Published: May 2023

Primary oocyte determination occurs in many organisms within a germ line cyst, a multicellular structure composed of interconnected germ cells. However, the structure of the cyst is itself highly diverse, which raises intriguing questions about the benefits of this stereotypical multicellular environment for female gametogenesis. Drosophila melanogaster is a well-studied model for female gametogenesis, and numerous genes and pathways critical for the determination and differentiation of a viable female gamete have been identified. This review provides an up-to-date overview of Drosophila oocyte determination, with a particular emphasis on the mechanisms that regulate germ line gene expression.
Novel Pneumocystis Antigens for Seroprevalence Studies
Authors: Pungan Dora , Fan Jia , Dai Guixiang , Khatun Mst Shamima , Dietrich Monika L. , Zwezdaryk Kevin J. , Robinson James E. , Landry Samuel J. , Kolls Jay K. 
Published: May 2023

Pneumocystis jirovecii is the most common cause of fungal pneumonia in children under the age of 2 years. However, the inability to culture and propagate this organism has hampered the acquisition of a fungal genome as well as the development of recombinant antigens to conduct seroprevalence studies. In this study, we performed proteomics on Pneumocystis-infected mice and used the recent P. murina and P. jirovecii genomes to prioritize antigens for recombinant protein expression. We focused on a fungal glucanase due to its conservation among fungal species. We found evidence of maternal IgG to this antigen, followed by a nadir in pediatric samples between 1 and 3 months of age, followed by an increase in prevalence over time consistent with the known epidemiology of Pneumocystis exposure. Moreover, there was a strong concordance of anti-glucanase responses and IgG against another Pneumocystis antigen, PNEG_01454. Taken together, these antigens may be useful tools for Pneumocystis seroprevalence and seroconversion studies.
PerancangannEnterprise Architecture Menggunakan ZachmannFramework di Unit LaboratoriumA Fakultas Ilmu Terapan Universitas Telkom
Authors: Handoko Refah Istifahani , Supatmi Sri 
Published: May 2023

Abstrak :

Volume 8 Nomor 1, 2022, 32-43 ISSN: 2460-1799 P-ISSN: 1432-602743
Refah Istifahani Handoko, Sri Supatmi
Jurusan.Magister Sistem Informasi.UNIKOM Jl. Dipati Ukur No. 112-116, Bandung, Jawa Barat, Indonesia
rerefahanihan@gmail.com

PerancangannEnterprise Architecture Menggunakan

ZachmannFramework di Unit LaboratoriumA

Fakultas Ilmu Terapan Universitas Telkom

ZachmanaframeworkAmerupakanAsalahAsatu metodeAdibuat untuk perancangan model arsitektur enterprise yang dapat

mendukung semua manajerial organisasi atau perusahaan agar bisa lebih memahami secara keseluruhan enterprise. Sehingga, organisasi dapat memiliki kemampuan untuk menenapkan struktur dasar organisasiAyang membantu sistem intrgrasi, pengembangan interpretasi, penataan serta perbaikan arsitektur perangkat sistem informasi yang dimiliki organisasi. Tujuan dari penelitian ini adalah agar tercapainnya secara optimal antara strategi Sistem Informasi dan Teknologi Informasi dengan strategi bisnis dan hasil dari penelititian

ini adalah berupa Blue Print.

Kata kunci : Enterprise Architecture, Zachman Framework, EAP
Cocarnit as a Part of Complex Therapy in Patients with Coronary Artery Disease and Chronic Heart Failure: A Clinical Experience
Authors: Кежун Л.В. 
Published: May 2023

Важным аспектом лечения пациентов кардиологического профиля, в частности с ишемической болезнью сердца, хронической сердечной недостаточностью, является применение кардиометаболических препаратов в составе комплексной терапии, направленных на улучшение энергетического метаболизма в сердечной мышце, коррекцию сосудистого эндотелия, восстановление баланса между интенсивностью процессов свободнорадикального окисления и антиоксидантной защиты, которые имеют большое значение в развитии и прогрессировании заболеваний сердечно-сосудистой системы. В статье представлен анализ опыта клинического применения Кокарнита – одного из современных кардиометаболических препаратов, действие которого реализуется на всех этапах развития гипоксических и ишемических повреждений тканей. Приведены способы и схемы его применения, сведения об эффективности его использования в клинической практике.
An important aspect of treatment of cardiac patients, in particular those with coronary heart disease and chronic heart failure, is the use of cardiometabolic drugs as a part of complex therapy, aimed at improving energy metabolism in the heart muscle, correcting the vascular endothelium, restoring the balance between the intensity of free radical oxidation and antioxidant protection, which are of great importance in the development and progression of cardiovascular system diseases. The article presents an analysis of the experience of clinical use of Cocarnit, one of the modern cardiometabolic drugs, which effect is realized at all stages of hypoxic and ischemic tissue lesions development. Methods and regimens of its application and information about the effectiveness of its use in clinical practice are presented.
Progress of computational plasma fluid mechanics
Authors: Shigeta Masaya 
Published: May 2023

Abstract
This article reviews and discusses the recent progresses of studies with the concept of “Computational plasma fluid mechanics.” Computational demonstrations show that the inhouse simulation codes such as PLasma All-Speed Turbulence with Implicit Pressure Code have captured hydrodynamic instabilities and reproduced flow dynamics in thermal plasma—nonionized gas coexisting systems. A unique method has made it feasible to study collective growth of binary alloy nanoparticles by numerical analysis. Smoothed Particle Hydrodynamics method with incompressibility modification has achieved complex behaviors of molten metal involving phase change, flow, heat transport, material mixing, and large deformation during arc welding. It is essential to study thermal plasma processes as comprehensive fluid systems in which hot plasma, cold nonionized gas, and materials coexist. The viewpoint and approaches of fluid mechanics as well as plasma physics are indispensable. Computational study will play a more important role in giving us new and deeper insights.
تاريخ التنافس الأوربي في الخليج العربي والمحيط الهندي: الإستراتيجية البحرية الفرنسية في القرنين السّابع عشر والثامن عشر نموذجا
Authors: النقبي محمد , الصغير نور الدين 
Published: May 2023

سنستعرض في هذا البحث بدايات التنافس الأوربي، منذ ان أصبح الخليج العربي يحظى بمكانة مهمة ناتجة عن اطلاع اروبا على مكاسب طريق الحرير ووصول البرتغاليين في القرن 16 م ومن بعدهم الفرنسيين إلى الخليج العربي والمحيط الهندي في القرنين 17 و18 م، كما سنرسم ملامح الاستراتيجية الفرنسية وسعيها إلى بسط نفوذها وفق خطط حكامها، إلى جانب سياسات التقارب والتحالف مع القوى المحلية في المنطقة.
وسنتتبع معالم التحركات البحرية الفرنسية ومدى نجاحها واخفاقها في فرض هيمنتها في بلاد ما وراء البحار خاصة نابليون بونابورت الذي رسم اول خطة للوصول إلى مياه الخليج من خلال التحالف مع سلاطين عمان ومنهم سلطان بن احمد بن سعيد وهي اول خطة وضعها الاروبيون للتحالفات الجديدة مع عمان عوضا عن الكيان الصفوي من خلال حركة التجارة والقرصنة والمعاهدات السياسية.