bluuebunny/crossref_metadata_2025_split huggingface dataset:
Towards digitalisation of quality management: conceptual framework and case study of auto-component manufacturer
Authors: Prashar Anupama 
Published: December 2022

PurposeIndustry 4.0-driven digitalisation is said to offer a way to redesign traditional compliance-oriented quality management (QM) models. However, despite a rising academic and practitioner interest, it is still unclear how companies transform their current QM models to meet the real-time needs of the new manufacturing paradigm. The purpose of this study is to explore practices for the digitalisation of QM and to uncover the digitalisation journey.Design/methodology/approachAn exploratory research approach of an embedded case study of a multinational auto-component manufacturer was adopted to achieve the research aim.FindingsA guiding framework called the “Quality 4.0 transition framework” was developed based on literature and expert knowledge. The framework is made up of three building blocks, i.e. the foundation of “as-is” digitalisation maturity assessment; pillars representing horizontally and vertically integrated QM processes, and roof signifying reinforcement of total quality management (TQM) principles at all levels.Originality/valueThe study provides empirical evidence of the case company's digitalisation journey to avert product recall due to field failure issues. The study contributes to theory and practice in many ways. First, the study uses empirical data from a real-world case to understand how digitalisation affects QM processes. Next, the guiding framework for the Quality 4.0 transition adds to the existing literature on the digitalisation of business processes.
Estradiol and raloxifene as adjunctive treatment for women with schizophrenia: A meta‐analysis of randomized, double‐blind, placebo‐controlled trials
Authors: Li Zijia , Wang Yucheng , Wang Zhe , Kong Lingtao , Liu Linzi , Li Liu , Tang Yanqing 
Published: December 2022

AbstractObjectivesWe conducted a comprehensive meta‐analysis of all available trials to evaluate the efficacy and safety of estrogen and selective estrogen receptor modulators as adjunctive treatment for women with schizophrenia.MethodsMultiple databases were searched from the inception until March 2022. Only randomized, double‐blind, placebo‐controlled studies (randomized controlled trials) were included. Mean differences (MDs) and their 95% confidence intervals (CIs) were calculated using random effects models.ResultsThe meta‐analysis included six estradiol versus placebo studies (n = 724) and seven raloxifene versus placebo studies (n = 419), covering a total of 1143 patients. Adjunctive estradiol outperformed the placebo in terms of the Positive and Negative Syndrome Scale (PANSS) total score (MD = −7.29; 95% CI = −10.67 to −3.91; I2 = 59.1%; p < 0.001; k = 9; N = 858), positive symptom score (MD = −1.54; 95% CI = −3.04 to −0.72; I2 = 45.8%; p < 0.001; k = 7; N = 624), negative symptom score (MD = −1.9; 95% CI = −1.77 to −0.34; I2 = 37.6%; p < 0.05; k = 14; N = 1042), and general psychopathology score (MD = −4.27; 95% CI = −7.14 to −1.41; I2 = 76.3%; p < 0.005; k = 7; N = 624). Adjunctive raloxifene outperformed the placebo in terms of the PANSS total score (MD = −6.83; 95% CI = −11.69 to −1.97; I2 = 67.8%; p = 0.006; k = 8; N = 432) and general psychopathology score (MD = −3.82; 95% CI = −6.36 to −1.28; I2 = 65.3%; p < 0.005; k = 8; N = 432).ConclusionsOur meta‐analysis showed that estradiol and raloxifene are effective and safe adjunctive treatments that improve schizophrenia symptoms in women. Moreover, the effects of estradiol and raloxifene differed in terms of timing and dosage. Both are promising adjunctive treatments that merit further study.
TLR8 agonist partially improves IFN‐γ deficiency of NK cells in chronic hepatitis B through the synergy of monocytes
Authors: Ao Xiulan , Gan Qiaorong , Huang Xuan , Bao Dongpeng , Wu Xuwei , Lin Qiuxiang , Lin Aifang , Ding Yating , Wang Lingxia , Chen Yanping , Huang Zuxiong 
Published: December 2022

SummaryBackgroundNatural killer (NK) cells exhibit a selective deficiency of IFN‐γ production in chronic hepatitis B (CHB). Toll‐like receptor 8 (TLR8) agonists could induce IFN‐γ production in immune cells, although their effects on the deficiency in NK cells remain unclear.AimsTo investigate TLR8 expression in NK cells and the effect of TLR8 agonists in patients with CHBMethodsWe enrolled 32 patients with CHB and 19 healthy controls to assess TLR8 expression and IFN‐γ production in NK cells. The sorted NK cells and monocytes were co‐cultured to compare the extent of IFN‐γ and IL‐10 production after TLR8 agonist ssRNA40 stimulation. The synergic effect of NK cells and monocytes was assessed by blocking IL‐12 and IL‐18. We recruited another 22 patients with CHB undergoing nucleotide analogue (NA) therapy to explore the impact of antiviral treatment on the ssRNA40‐mediated response of NK cells.ResultsIn patients with CHB, TLR8 expression in NK cells was up‐regulated, accompanied by insufficient IFN‐γ production. The enhanced IFN‐γ secretion by ssRNA40 in NK cells depended on monocyte‐derived IL‐12 and IL‐18. NK cells displayed an imbalanced response to ssRNA40 in patients with CHB with a weak increase in IFN‐γ despite a higher IL‐10 production. The response was improved in patients with CHB undergoing NA therapy.ConclusionsIn patients with CHB, targeting TLR8 partially rescues the IFN‐γ insufficiency in NK cells. However, NK cells show an inhibitory response to TLR8 agonist stimulation. TLR8 agonist combined with NA may enhance the antiviral effect of NK cells.
Reconsidering North Korean defectors: Social and semantic network analyses of YouTube videos on North Korean defectors
Authors: Chung Sae Won , Kim Yongmin 
Published: December 2022

AbstractThis study investigates the North Korean defector phenomenon by approaching YouTube as an internet forum for public discourse, using the novel analytic approaches of social network analysis, text mining and semantic analysis. The research produced three main findings. First, individual YouTube content creators are most influential in the video networks pertaining to the subject of North Korean defectors. Second, on YouTube space, the image of North Korea tends to be negative because of the prevalence of defectors' testimony of their life experiences. Finally, such negative narratives of North Korea on YouTube might have a negative influence by blocking the reunification of Korea. In conclusion, this study suggests the South Korean government and other relevant global actors should conduct thorough and continuous examinations of North Korean defectors' perceptions of South Koreans and vice versa. This study calls for the international community to take further action to formulate proper policy instruments.
High incidence of intracranial haemorrhage in Egyptian children with congenital afibrinogenaemia
Authors: Abdelwahab Magy , de Moerloose Philippe , Casini A. 
Published: December 2022

AbstractIntroductionIntracerebral hemorrhage (ICH) is associated with high morbidity and mortality in patients with congenital afibrinogenaemia. Details on location of cerebral haemorrhage, management and neurological outcomes are lacking.MethodsWe performed a retrospective study on Egyptian children with congenital afibrinogenaemia who experienced ICH, in order to estimate frequency, symptoms and neurological outcomes.ResultsAmong 58 children with congenital afibrinogenaemia treated on demand, 18 (31%) had an history of ICH (28 episodes). The first ICH occurred at a median age of 1 year (Q1‐Q3 1–7 years). Impaired consciousness level, vomiting and seizures were the most common presenting symptoms. Spontaneous bleeding was associated with a more severe clinical presentation and worse neurological outcomes, including hydrocephaly and impaired cognitive development. Only half of ICH events (n = 14) were treated in less than 24 h from the onset of symptoms. Fibrinogen replacement by Fresh Frozen Plasma (FFP), cryoprecipitate or fibrinogen concentrates was administered in seven (25%), 19 (68%) and three (10%) ICH events, respectively. Overall, seven (25%) ICH occurring in four patients required a surgical intervention. After the ICH, six patients started secondary prophylaxis. The cumulative incidence of ICH at 10 years was 35% (95% CI 23–51) and at 20 years was 40% (95 CI% 26.7–58.8).ConclusionIn our cohort of children with congenital afibrinogenaemia, ICH was very frequent and associated with adverse neurological outcomes and death. Further studies are required to determine whether primary prophylaxis starting early in childhood is indicated after diagnosis.
Ab initio study of boron‐rich amorphous boron carbides
Authors: Yıldız Tevhide Ayça , Durandurdu Murat 
Published: January 2023

AbstractAmorphous boron carbide compositions having high B contents (BxC1−x, 0.50 ≤ x ≤ 0.95) are systematically created by way of ab initio molecular dynamics calculations, and their structural, electrical, and mechanical characteristics are inclusively investigated. The coordination number of both B and C atoms increases progressively with increasing B/C ratio and more close‐packed materials having pentagonal pyramid motifs form. An amorphous diamond‐like local arrangement is found to be dominant up to 65% B content, and beyond this content, a mixed state of amorphous diamond– and B‐like structures is perceived in the models because sp3hybridization around C atoms is still leading one for all compositions. The pentagonal pyramid motifs around C atoms are anticipated to appear beyond 65% content. The intericosahedral linear C–B–C chains do not form in any model. All amorphous boron carbides are semiconducting materials. The mechanical properties gradually increase with increasing B concentration, and some amorphous compositions are proposed to be hard materials on the basis of their Vickers hardness estimation.
Serum aldosterone effect on left ventricular structure and diastolic function in essential hypertension
Authors: Al‐Hashedi Ekhlas Mahmoud , Zhao Xu , Mohammed Ayman A. , Juvenal Havyarimana , Yu Jing 
Published: December 2022

AbstractAldosterone has hypertrophic and profibrotic effects on the heart. This study aims to determine the relationship between serum aldosterone concentration (SAC) and aldosterone‐to‐renin ratio (ARR) with left ventricular (LV) geometry and diastolic function in essential hypertension (EH). We investigated 213 EH patients (50.3 ± 12.6 years; 57.7% male). SAC, ARR measurements, and echocardiographic analysis were performed for participants. Overall, stepwise multiple regression analysis showed significant associations between SAC and interventricular septum, LV posterior wall thickness, LV amass, LV mass index, e′ velocity, a′ velocity, and E/e′ ratio after adjustment of potentially confounding covariates. When patients were divided into three SAC tertiles, multivariate‐adjusted analysis of covariance (ANCOVA) demonstrated a significant increase in LV mass (P ˂ 0.001), LV mass index (P ˂ 0.001), relative wall thickness (P = 0.003), interventricular septum (P = 0.001), LV posterior wall thickness (P = 0.001) and E/e′ ratio (P ˂ 0.001), but a decrease in e′ velocity (P = 0.002) from the first to third tertile of SAC. In logistic regression analysis, increased SAC was independently associated with concentric LV hypertrophy [OR: 1.21, 95% CI: 1.11–1.33, P ˂ 0.001]. No significant associations were found between ARR and echocardiographic parameters of LV structure or diastolic function. In conclusion, SAC, but not ARR, is independently associated with echocardiographic indices of LV structure and diastolic function and is also related to concentric LV hypertrophy. Our findings suggest that aldosterone's pro‐hypertrophic and myocardial fibrosis effects contribute to alterations in LV structure and diastolic function in EH beyond blood pressure.
Hypertension, a linchpin between environmental noise exposure and the development of cardiovascular disease?
Authors: Salazar Martin R. 
Published: December 2022

AbstractEnvironmental noise exposure has been considered one of the most common hazards worldwide, especially in the workplace environment, and could produce a variety of health issues. Some epidemiological evidence supports the association between occupational noise exposition and a high risk for hypertension and cardiovascular diseases. Wang et al. has conducted an observational cross‐sectional study using occupational data of 4746 workers, 32.4% were exposed to high occupational noise. These exposed individuals had a moderate increase in the risk for hypertension (adjusted odds ratio [OR], 1.30; 95% confidence interval [CI], 1.05–1.62). The subgroup analyses showed that the relationship between noise and hypertension prevalence was stronger in young participants (OR, 1.70; 95% CI, 1.21–2.40). Noise exposure activates the sympathetic and endocrine systems producing an increase in blood pressure and the changes in other biological risk factors. Moreover, a recently published study showed that oxidative stress and DNA damage were significantly higher in subjects exposed to noise. Emotional stress reactions and unconscious physiological stress could also be potential mechanisms for hypertension. Finally, physiological stress caused by noise exposure may also increase indulgence in unhealthy behaviors, such as smoking and alcohol consumption, and indirectly result in an increased risk of hypertension and cardiovascular diseases. Previously published studies showed relationships between environmental noise exposure (including road traffic, railway, and aircraft noises) and the development of hypertension and cardiovascular diseases. Thus, the study by Wang et al. emphasizes the importance of environmental control in the prevention of cardiovascular diseases, not only in the workplace but also outside it.
Using artificial intelligence to predict the final color of leucite‐reinforced ceramic restorations
Authors: Kose Carlos , Oliveira Dayane , Pereira Patricia N. R. , Rocha Mateus Garcia 
Published: January 2023

AbstractObjectivesThe aim of this study was to evaluate the accuracy of machine learning regression models in predicting the final color of leucite‐reinforced glass CAD/CAM ceramic veneer restorations based on substrate shade, ceramic shade, thickness and translucency.MethodsLeucite‐reinforced glass ceramics in four different shades were sectioned in thicknesses of 0.3, 0.5, 0.7, and 1.2 mm. The CIELab coordinates of each specimen were obtained over four different backgrounds (black, white, A1, and A3) interposed with an experimental translucent resin cement using a calibrated spectrophotometer. The color change (CIEDE2000) values, as well as all the CIELab values for each one of the experimental groups, were submitted to 28 different regression models. Each regression model was adjusted according to the weights of each dependent variable to achieve the best‐fitting model.ResultsDifferent substrates, ceramic shades, and thicknesses influenced the L, a, and b of the final restoration. Of all variables, the substrate influenced the final ceramic shade most, followed by the ceramic thickness and the L, a, and b of the ceramic. The decision tree regression model had the lowest mean absolute error and highest accuracy to predict the shade of the ceramic restoration according to the substrate shade, ceramic shade and thickness.Clinical SignificanceThe machine learning regression model developed in the study can help clinicians predict the final color of the ceramic veneers made with leucite‐reinforced glass CAD/CAM ceramic HT and LT when cemented with translucent cements, based on the color of the substrate and ceramic thicknesses.
The regional turn to modernist studies in Singapore
Authors: Tan Teck Heng 
Published: January 2023

AbstractThe past decade or so saw a regional turn to modernist studies in Singapore. Numerous projects are mapping out the networks of institutions, artists, and writers that disseminated and reinvented Euro‐American modernism in Southeast Asia from the 1930s. While this networked approach enables the recovery of neglected modernists in the non‐West, particularly women, it is also too neatly aligned with Singapore's self‐branding as a global city and its ongoing accumulation of cultural capital. Related scholarship is circumscribed by a tension between a desire to diversify modernist studies and a narrow fixation on connecting Singapore‐based artists and writers to already established modernist networks. In the process, an implicit conception of modernity and modernism that privileges connectivity, mobility, and capital is installed. Consequently, inconvenient facets of regional art and literature, as well as intra‐regional connections, are overlooked. I examine how these dynamics play out in projects on the Nanyang artists and writers, a group of diasporic Chinese literati who worked in Southeast Asia following their exposure to Euro‐American modernism. In closing, I turn to emergent avenues of research which counteract the nationalist slant to the study of regional modernisms in Singapore.
Non‐ergot dopamine agonist therapy for Parkinson's disease in Japan: A claims database analysis
Authors: Wada‐Isoe Kenji , Tsuboi Yoshio , Kondo Hiroyuki , Kojima Yoshitsugu , Takeshima Tomomi , Iwasaki Kosuke 
Published: January 2023

AbstractBackgroundLevodopa monotherapy and combination therapy with non‐ergot dopamine agonists (DAs; pramipexole, ropinirole, and rotigotine) are commonly used in patients with Parkinson's disease (PD). Changes in prescription preferences for each DA were reported previously; however, information regarding the selection of individual DAs is insufficient.AimTo investigate the reasons for selecting each DA.MethodsThis observational study used a Japanese claims database (April 2008–July 2017). The percentage of patients prescribed each DA was analyzed by year (2010–2017). The change in DA prescriptions and prevalence of comorbidities before DA initiation or before replacement with another DA were analyzed from 2013.ResultsThe database included 50,408 patients with PD who received ≥1 levodopa and/or DA prescriptions. Pramipexole was the most popular DA; however, its prescription has decreased since 2012. Ropinirole prescriptions remained relatively unchanged, while that of rotigotine tended to increase since its launch in 2013 and recently surpassed that of ropinirole. The most frequent pattern of change (both in addition and replacement) was from pramipexole to rotigotine. Differences were observed in the prevalence of comorbidities among DAs.ConclusionPramipexole was often prescribed at the beginning of the study period; the decrease in its prescription frequency might be mainly related to new DA options. The frequent change from pramipexole to rotigotine might be associated with the different DA characteristics, which may be a factor influencing the choice of a specific DA.
Is Patient‐Specific Instrumentation Accurate and Necessary for Open‐Wedge High Tibial Osteotomy? A Meta‐Analysis
Authors: Pang Ran , Jiang Zhaohui , Xu Chunlei , Shi Wei , Zhang Xinglong , Wan Xin , Bahat Daniel , Li Hui , Senatov Fedor , Bulygina Inna , Wang Hu , Zhang Huafeng , Li Zhijun 
Published: December 2022

The purpose of this meta‐analysis was to identify if patient‐specific instrumentation (PSI) could increase the accuracy of the correction in high tibial osteotomy (HTO) and to explore the assessment indices and the necessity of using a PSI in HTO. A systematic search was carried out using online databases. A total of 466 patients were included in 11 papers that matched the inclusion criteria. To evaluate the accuracy of PSI‐assisted HTO, the weight bearing line ratio (WBL%), hip‐knee‐ankle angle (HKA), mechanical medial proximal tibial angle (mMPTA), and posterior tibial slope angle (PTSA) were measured preoperatively and postoperatively and compared to the designed target values. Statistical analysis was performed after strict data extraction with Review Manager (version 5.4). Significant differences were detected in WBL% (MD = −36.41; 95% CI: −42.30 to −30.53; p < 0.00001), HKA (MD = −9.95; 95% CI: –11.65 to –8.25; p < 0.00001), and mMPTA (MD = –8.40; 95% CI:−10.27 to −6.53; p < 0.00001) but not in PTSA (MD = 0.34; 95% CI: −0.59 to 1.27; p = 0.47) between preoperative and postoperative measurements. There was no significant difference between the designed target values and the postoperative correction values of HKA (MD = 0.14; 95% CI: −0.19 to 0.47; p = 0.41) or mMPTA (MD = 0.11; 95% CI −0.34 to 0.55; p = 0.64). The data show that 3D‐based planning of PSI for HTO is both accurate and safe. WBL%, HKA, and mMPTA were the optimal evaluation indicators of coronal plane correction. Sagittal correction is best evaluated by the PTSA. The present study reports that PSI is accurate but not necessary in typical HTO.
Crosstalk and trade‐offs: Plant responses to climate change‐associated abiotic and biotic stresses
Authors: Leisner Courtney P. , Potnis Neha , Sanz‐Saez Alvaro 
Published: December 2022

AbstractAs sessile organisms, plants are constantly challenged by a dynamic growing environment. This includes fluctuations in temperature, water availability, light levels, and changes in atmospheric constituents such as carbon dioxide (CO2) and ozone (O3). In concert with changes in abiotic conditions, plants experience changes in biotic stress pressures, including plant pathogens and herbivores. Human‐induced increases in atmospheric CO2 levels have led to alterations in plant growth environments that impact their productivity and nutritional quality. Additionally, it is predicted that climate change will alter the prevalence and virulence of plant pathogens, further challenging plant growth. A knowledge gap exists in the complex interplay between plant responses to biotic and abiotic stress conditions. Closing this gap is crucial for developing climate resilient crops in the future. Here, we briefly review the physiological responses of plants to elevated CO2, temperature, tropospheric O3, and drought conditions, as well as the interaction of these abiotic stress factors with plant pathogen pressure. Additionally, we describe the crosstalk and trade‐offs involved in plant responses to both abiotic and biotic stress, and outline targets for future work to develop a more sustainable future food supply considering future climate change.