bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengaruh Motivasi dan Kepuasan Kerja terhadap Kinerja Karyawan pada PT Tata Rekatama Bunindo Kota Jakarta Selatan
Authors: Rahmah Nur , Ma'fiyah Ma'fiyah 
Published: January 2025

Tujuan penelitian ini adalah untuk mengetahui pengaruh motivasi dan kepuasan kerja terhadap kinerja karyawan pada PT Tata Rekatama Bunindo Jakarta Selatan baik secara parsial maupun simultan. Metode yang digunakan adalah metode kuantitatif. Populasi pada PT Tata Rekatama Bunindo Jakarta Selatan sebanyak 100. Sampel yang digunakan dalam penelitian ini sebanyak 66 responden yang didapatkan dari tingkat error 5% menggunakan rumus Teknik Slovin. Analisis dalam penelitian ini menggunakan program SPSS. Metode analisis data menggunakan statistik deskriptif, uj validitas, uji reliabilitas, uji normalitas, uji multikolinieritas, uji heteroskedastisitas, uji autokorelasi, uji regresi linier sederhana, regresi linier berganda, koefisien korelasi, koefisien determinasi, uji t parsial dan uji F simultan. Hasil penelitian menunjukan bahwa: (1) secara parsial terdapat pengaruh antara motivasi terhadap kinerja karyawan pada PT Tata Rekatama Bunindo Jakarta Selatan. Hal tersebut dapat dibuktikan dari persamaan regresi linier sederhana Y = 16.570 + 0.452 X1 dan nilai thitung 3,450 > ttabel 1,997 dengan tingkat signifikan 0,000 < 0,05 maka H01 ditolak dan Ha1 diterima. (2) secara parsial terdapat pengaruh antara kepuasan kerja terhadap kinerja karyawan pada PT Tata Rekatama Bunindo Jakarta Selatan hal tersebut dapat dibuktikan dari persamaan regresi linier sederhana Y = 5.188 + 0.961 dan nilai thitung 7,126 > ttabel 1,997 dengan tingkat signifikan 0,000 < 0,05 maka H02 ditolak dan Ha2 diterima. (3) secara simultan terdapat pengaruh motivasi dan kepuasan kerja hal tersebut dapat dibuktikan dari persamaan regresi linier berganda Y = 0.607 + 0.166 X1 + 0.915 X2, nilai korelasi sebesar 0,671, nilai koefisien determinasi sebesar 45 % serta nilai Fhitung 25,796 > Ftabel 3,14 dan tingkat siginifikan 0,000 < 0,05.
Implementasi Kebijakan Pembangunan Industri Rumahan Melalui Pemberdayaan Perempuan di Kabupaten Kulon Progo
Authors: Hartati Esti , Nurdin Nurliah , Rivai Firman Hadi 
Published: January 2025

Industri rumahan merupakan salah satu jenis usaha mikro yang dikerjakan di rumah dan sebagian besar pelaku usahanya adalah perempuan, hal ini dapat memberikan peran kepada perempuan untuk dapat membantu meningkatkan kesejahteraan keluarga, menciptakan tenaga kerja dan ikut terlibat dalam pembangunan terutama di bidang ekonomi. Dalam mengembangkan industri rumahan, perlu peran serta pemerintah baik pusat maupun daerah, berdasarkan hal ini, KemenPPPA mengeluarkan Peraturan Menteri Nomor 2 Tahun 2016 tentang Pedoman Umum Pembangunan Industri Rumahan untuk Meningkatkan Kesejahteraan Keluarga melalui Pemberdayaan Perempuan, dan 21 Kab/Kota terpilih untuk dijadikan percontohan. Kabupaten Kulon Progo sebagai salah satu daerah percontohan pembangunan Industri Rumahan karena tingginya angka kemiskinan. Dalam pelaksanaannya, Kabupaten Kulon Progo menunjukkan perkembangan industri rumahan yang belum optimal. Tujuan penelitian untuk menganalisis penyebab ketidakoptimalan pelaksanaan pembangunan industri rumahan di Kulon Progo serta strategi pelaksanaannya. Penelitian ini merupakan pendekatan kualitatif dengan menganalisis menggunakan teori Shabbir Cheema dan Dennis A. Rondinelli, dimana terdapat empat variabel yang dapat mempengaruhi kinerja dan dampak suatu program, yakni kondisi lingkungan, hubungan antar organisasi, sumber daya organisasi, dan karakteristik dan kemampuan lembaga pelaksana. Hasil penelitian menunjukkan bahwa pelaksanaan pembangunan industri rumahan melalui pemberdayaan perempuan di Kabupaten Kulon Progo belum optimal dari setiap variabel, penyadaran pola pikir pelaku usaha, pelatihan-pelatihan, koordinasi dan penganggaran sehingga diperlukannya strategi dimana kerjasama, peran dan komitmen bersama antara pemerintah, akademisi, pelaku usaha dan lembaga masyarakat sangat penting untuk mencapai tujuan yang sama dalam pembangunan industri rumahan.
Kata Kunci: Industri Rumahan, Pemberdayaan Perempuan
Kod Etika Wartawan Malaysia 2024 Daripada Perspektif Maqasid Syariah
Authors: Kamaruddin Nur Kamilah , Ab Alim Nik Nurul Akmal , Ab Rahman Nor Azrina @ Nor Azura , Sabaruddin Siti Nor Azimah 
Published: January 2025

Kewartawanan telah menjadi satu medium saluran berita dan maklumat rasmi kepada masyarakat. Bagi memastikan agensi media menjalankan tanggungjawab dengan baik, Jabatan Penerangan Malaysia (JaPen) telah melancarkan Kod Etika Wartawan Malaysia 2024 bagi menggantikan kod etika wartawan lama yang telah digunakan sejak 1989. Namun, wujud keperluan kepada satu kajian bagi menentukan keselarasan antara etika kewartawanan tersebut dengan maqasid syariah. Sehubungan dengan itu, kajian ini dijalankan bagi menganalisis penetapan Kod Etika Wartawan Malaysia 2024 menurut perspektif maqasid syariah. Kajian ini dilihat penting kerana memahami peranan maqasid syariah secara menyeluruh dapat membantu wartawan melaksanakan tugas mereka secara profesional, beretika dan berintegriti. Hal ini dapat memerangi penyebaran maklumat palsu seterusnya memartabatkan media sebagai sumber berita dan maklumat yang boleh dipercayai rakyat. Bagi mencapai objektif kajian, pengkaji menggunakan pendekatan kualitatif dengan menganalisis dokumen Kod Etika Wartawan 2024 secara kritis dengan menggunakan kaedah analisis tematik. Kajian kepustakaan turut dijalankan bagi mengkaji literatur berkaitan etika kewartawanan, maqasid syariah, dan kaedah fiqh. Hasil kajian mendapati bahawa kesemua lapan etika utama dalam Kod Etika Wartawan Malaysia 2024 adalah sejajar dengan matlamat syarak khususnya dalam pemeliharaan agama, nyawa, akal, maruah dan harta.

Kata kunci: Fiqh Kewartawanan, Wartawan, Kod Etika Wartawan Malaysia 2024, JaPen, Maqasid Syariah
PENGARUH PROBLEM BASED LEARNING DALAM DIFFERENTIATED INSTRUCTION TERHADAP KEMAMPUAN KOMUNIKASI MATEMATIS SISWA KELAS VII
Authors: Kartika Amalia , Syaiful Syaiful , Sofnidar Sofnidar 
Published: January 2025

Rendahnya kemampuan komunikasi matematis siswa di SMP N 14 Kota Jambi serta model pembe-lajaran yang diterapkan dikelas tidak menjadikan siswa sebagai pusat belajar. Penelitian ini bertujuan untuk mengetahui pengaruh yang signifikan dari Penerapan model Problem Based Learning dalam Differentiated Instruction terhadap kemampuan komunikasi matematis siswa kelas VII. Penelitian ini menggunakan metode eksperimential yaitu dimulai dari pemberian soal pretest mengenai materi kese-bangunan dengan penilaian indikator kemampuan komunikasi matematis, lalu observasi keterlaksanaan aktivitas guru dan siswa, serta pemberian soal posttest yang mana semua perlakuan ini berlaku untuk kelas eksperimen dan kontrol. Selanjutnya data yang telah didapat akan di olah dan di analisis. Penelitian ini menggunakan pretest-posttest control group design dengan populasi siswa kelas VII. Teknik pengambilan sampel berupa simple random sampling. Sampel penelitian adalah kelas VII F yang diberi perlakuan dengan model Problem Based Learning dan kelas VII G yang diberi perlakuan dengan model pembelajaran konvensional. Data penelitian diperoleh melalui lembar observasi dan tes (pretest dan posttest). Hasil penelitian mengindikasi bahwa model Problem Based Learning terhadap kemampuan komunikasi matematis siswa pada materi kesebangunan kelas VII SMP N 14 Kota Jambi. Berdasarkan uji t terhadap data posttest berbantuan software SPSS 26 for windows didapatkan yaitu dan uji lanjut omega squared diperoleh pengaruh berupa peningkatan kemampuan komunikasi matematis siswa sebesar 16,31% sedangkan 83,69% ditentukan oleh faktor-faktor lain yang tidak diketahui.
PENGARUH MODEL PROBLEM BASED LEARNING PADA PEMBELAJARAN MATEMATIKA TERHADAP KEMAMPUAN BERPIKIR KRITIS MATEMATIS SISWA KELAS VIII
Authors: Sundari Fitri , Setyawati Astri , Qomariyah Siti 
Published: January 2025

Penelitian ini bertujuan untuk mengetahui pengaruh model pembelajaran Problem Based Learning (PBL) Kemampuan Berpikir Kritis Matematis Siswa Kelas VIII. Penelitian ini dilaksanakan pada semester ganjil tahun pelajaran 2024/2025. Latar belakang penelitian ini adalah rendahnya Kemampuan Berpikir Kritis Matematis Siswa. Penelitian ini termasuk penelitian kuantitatif. Penelitian kuantitatif yang digunakan dalam penelitian ini adalah jenis penelitian eksperimen. Metode penelitian yang digunakan untuk mencari pengaruh perlakuan/tindakan/treatment tertentu terhadap yang lain dalam kondisi yang terkendalikan. Desain eksperimen yang digunakan adalah quasi eksperimen design. Populasi dan sampel yang digunakan adalah sebanyak 60 siswa, yakni 30 siswa kelas VIIIA dan 30 siswa kels VIIIB. Karena populasi dalam penelitian ini berjumlah 60 siswa dengan hal itu berarti jumlah subyeknya kurang dari 100 maka peneliti menggunakan teknik sampling jenuh. Hasil penelitian menunjukkan bahwa rata-rata hasil post-test kelas kontrol sebesar 23.57 dan post-test kelas eksperimen sebesar 74.93. Terdapat selisih antara rata-rata antara hasil post-test kelas eksperimen dan kontrol sebesar 51.36 yaitu rata-rata post-test kelas kontrol post-test kelas eksperimen, yang berarti nilai rata-rata post-test kelas eksperimen lebih besar dari post-test kelas kontrol. Hal ini menunjukkan adanya perbedaan yang signifikan antara diberi perlakuan model pembelajaran konvensional dan diberi perlakuan model pembelajaran Problem Based Learning. Berdasarkan hasil penelitian dari pembahasan yang telah diuraikan, diperoleh nilai = 17.61 dan = 1.70, karena (17.69 1.70), maka diterima dan terdapat pengaruh yang positif penggunaan model pembelajaran Problem Based Learning terhadap kemampuan berpikir kritis matematis siswa.
Study on the synergistic preparation of functional soil from multiple coal-based solid wastes
Authors: Liu Yanan , Han Fenglan , Li Ning , Dong Fuyuan , An Changcong , Yang Wenna , Li Tingfeng 
Published: January 2025

Three coal-based solid wastes—fly ash (FA), gasification slag (GS), and coal gangue (CG)—were used to prepare functional soil (FGC) for the ecological restoration of mining areas. It not only solves the problem of shortage of soil resources in the mining area, but also realizes the resourceful use of coal-based solid waste. Investigating the functional soil physicochemical properties and oatgrass growth characteristics revealed the optimal functional soil ratios. Compared with the control (CK) at 30 d, the average pH of the FGC3 (FA: 50wt%; GS: 25wt%; CG: 25wt%) decreased from 9.54 to 8.54, the average organic matter content increased from 2.57% to 7.60%, and the average available potassium and ammonium nitrogen content increased from 38.02 to 2.83 mg⋅kg−1 to 53.46 and 3.21 mg⋅kg−1, respectively. Functional soil bulk density and porosity were superior to Sandy soil somewhere in Ningxia (SL) for GS and CG contents &lt;25wt%. GS and CG significantly improved oatgrass agronomic traits. Compared with CK the average plant height, stem thickness, fresh weight, and dry weight of oatgrass in FGC3 increased from 17.68 cm, 0.99 mm, 0.09 g, and 0.02 g to 27.0 cm, 1.26 mm, 0.24 g, and 0.04 g, respectively. And chlorophyll content was increased by 20.39% compared with CK. This study verified the feasibility of the synergistic preparation of functional soils from three coal-based solid wastes and provides reference for the ecological restoration and large-scale utilization of coal-based solid wastes.
Digital economy, green innovation and regional resource allocation efficiency: evidence from 257 cities in China
Authors: Jiang Li , Zhang Min , Hu Shihui 
Published: January 2025

IntroductionThe digital economy is reshaping economic structures and resource flows, but its role in enhancing resource allocation efficiency within the framework of green development has not yet been fully explored.MethodsThis paper analyzes panel data from 257 Chinese cities to investigate how the digital economy influences regional resource allocation efficiency, with a focus on the mediating role of green innovation.ResultsThe results show that the digital economy significantly improves resource allocation efficiency, with nonlinear effects characterized by increasing marginal returns. Mechanism tests reveal that the digital economy optimizes resource allocation by fostering green innovation. Heterogeneity analysis indicates that in eastern regions and areas with strong environmental regulations, the digital economy promotes both substantive and strategic green innovations, leading to higher efficiency. In mid-western regions, only substantive green innovation has a significant effect, while regions with weak environmental regulations experience less pronounced impacts.DiscussionThis study offers insights into leveraging green innovation to achieve efficient resource allocation and strengthen environmental resilience in the digital era.
Climate change and urban forests: generational differences in women’s perceptions and willingness to participate in conservation efforts
Authors: Maleknia Rahim , Elena Enescu Raluca , Salehi Tayebeh 
Published: January 2025

IntroductionClimate change represents one of the most pressing challenges confronting contemporary societies. Despite occupying a relatively small proportion of the Earth’s surface, cities contribute disproportionately to greenhouse gas emissions. Urban forests, as a vital form of natural infrastructure, play a critical role in mitigating the adverse impacts of climate change. Effective management and conservation of these resources necessitate active engagement from diverse stakeholder groups, with women being a particularly important demographic. However, generational differences in women’s perceptions of climate change and their willingness to participate in urban forest conservation have received limited investigation. This study seeks to address this gap by comparing the perceptions and conservation participation intentions of two groups of women: those belonging to Generation Z and women from earlier generations.MethodsThe sample comprised 401 women from Generation Z and 395 women from other generations. Data for the study were collected using a questionnaire administered through a multi-stage cluster sampling method. The collected data encompassed participants’ awareness of climate change, its causes, the dual impacts of climate change and urban forests, their willingness to engage in urban forest management, and their demographic characteristics such as age, educational level, family size, family income, highest education in family, and educational levels of fathers and mothers. The analysis was conducted using both descriptive and inferential statistical methods.ResultsThe results revealed significant generational differences in understanding climate change, recognizing the role of forests in mitigating its effects, and demonstrating willingness to engage in urban forest conservation. Across all measures, Generation Z exhibited higher levels of awareness and willingness compared to older generations. Furthermore, increased awareness of these issues in both groups was positively associated with a greater willingness to participate in urban forest management. Socio-economic factors also influenced willingness differently between the two generational groups, highlighting the nuanced effects of these variables on participation intentions.DiscussionThe results showed althought differences in awareness were observed between the two groups, increased awareness consistently led to a heightened willingness among both groups to participate in urban forest conservation. These findings underscore the importance of adopting intergenerational perspectives on climate change, emphasizing that educational and promotional programs must be tailored to account for generational differences to effectively maximize engagement and foster widespread participation in urban forest conservation efforts.
Elucidating the causal associations and mechanisms between circulating immune cells and idiopathic pulmonary fibrosis: new insights from Mendelian randomization and transcriptomics
Authors: Yang Han , Wu Xuanyu , Xiao Xiang , Chen Jiajing , Yu Xiaomin , Zhao Wen , Wang Fei 
Published: January 2025

BackgroundGrowing evidence indicates an association between circulating immune cell phenotypes and idiopathic pulmonary fibrosis (IPF). Although studies have attempted to elucidate the causal relationship between the two, further clarification of the specific mechanisms and causal linkages is warranted.ObjectiveWe aimed to conduct a two-sample Mendelian randomization (MR) analysis with transcriptomics data analysis to elucidate the causal relationship between circulating immune cells and IPF and to explore potential biomarkers.MethodsWe first explored the bidirectional causal association between IPF and immune cell phenotypes using two-sample MR analysis. Genome-wide association studies data for immune cell phenotype and IPF were obtained from publicly available databases. A standardized instrumental variable screening process was used to select single nucleotide polymorphisms (SNPs) for inclusion in the MR. Five methods represented by IVW were used to assess causal effects. Subsequently, SNP-nearest genes combined with the transcriptomics data of IPF were subjected to multiple bioinformatics analyses such as TIMER, WGCNA, functional enrichment analysis, protein-protein interaction analysis, and ROC to identify IPF biomarkers. Finally, the single-cell RNA sequencing (scRNA-seq) data was used to validate our findings by single-cell analysis.ResultsThe MR study identified 27 immune cell phenotypes causally associated with IPF, of which 20 were associated with a decreased risk of developing IPF and 7 were associated with an increased risk. CTSB (AUC=0.98), IL10 (AUC=0.83), and AGER (AUC=0.87) were identified as promising biomarkers of IPF. Single cell analysis showed differences in CD14+ CD16+ monocytes, CD16+ monocytes and Granulocyte-monocyte progenito between the IPF group and the healthy control group. The three hub genes were highly expressed in three immune cell subsets of IPF patients. It underscores the potential feasibility of three genes as biomarkers.ConclusionsOur study demonstrates the causal associations of specific immune cell phenotypes with IPF through genetic methods and identifies CTSB, IL10, and AGER as biomarkers of IPF through bioinformatics analysis. These findings provide guidance for future clinical and basic research.
Mechanistic PKPD modeling to describe cytokine release associated with CD3 T-cell engager therapies
Authors: Lefèvre Apolline , Parra-Guillen Zinnia P. , Trocóniz Iñaki F. , Boetsch Christophe , Frances Nicolas 
Published: January 2025

IntroductionT-cell engagers (TCE), a therapeutic class of cancer immunotherapy (CIT), offer a novel approach to cancer treatment by harnessing and reactivating the patient’s immune system to eradicate tumor cells. However, the use of TCE in the clinic can lead to severe side effects, including cytokine release syndrome (CRS). Therefore, innovative dosing strategies need to be implemented to mitigate the risk of developing CRS.MethodIn the presented work, a mechanistic pharmacokinetics/pharmacodynamics (PKPD) model describing cytokine release following TCE therapy has been developed combining literature knowledge and preclinical data. The model was developed to explore and test hypotheses regarding the mechanisms behind the decrease of cytokine release following two repeated TCE administrations.ResultsThe model is able to successfully reproduce the observed dynamics of cytokine levels associated with the initial and subsequent TCE doses, accounting for different dosing intervals. In addition, the model suggests a mechanism of action that uncouples cytokine release from tumor cell killing.DiscussionThis model provides an initial mechanistic framework to support the design of experiments and paves the way for the application of mathematical modeling to support clinical dosing regimen selection of any TCE.
Efficacy and safety of neoadjuvant chemoimmunotherapy and chemotherapy in patients with potentially resectable stage IIIA/IIIB NSCLC: a retrospective study
Authors: Wang Yuchen , Ma Xiaobo , Ma Kewei , Chen Xi , He Hua , Zhao Xiangye , Fan Mengge , Xu Yinghui 
Published: January 2025

BackgroundTreatment of locally advanced unresectable non-small cell lung cancer (NSCLC) is a significant challenge, especially for patients with IIIA/IIIB NSCLC. Patients receiving neoadjuvant chemoimmunotherapy (NCI) show improved pathological responses and disease-free survival (DFS) compared to those receiving Neoadjuvant chemotherapy (NC). However, there is still no consensus on the treatment for potentially resectable stage IIIA/IIIB NSCLC.MethodsThis retrospective study included 71 patients newly diagnosed with stage III NSCLC at our institution between 2017 and 2023: 46 patients received NCI and 25 patients received NC followed by surgical resection. Their clinicopathological characteristics were reviewed and analyzed.ResultsPatients who received NCI had a significantly longer DFS. The median DFS was 15 months in the NC group (hazard ratio: 0.186, 95% confidence interval[CI]: 0.073–0.479; P&lt;0.001) but had not been reached in the NCI group. The percentage of patients achieving a major pathologic response was 65.9% (29/44, 95% CI: 50.0%–79.1%) with NCI and 16.7% (4/24, 95% CI: 5.5%–38.2%) with NC alone(P&lt;0.001). The percentage of patients with pathologic complete response was 36.4% (16/44, 95% CI: 22.8%–52.3%) after NCI compared with 8.3% (2/24, 95% CI: 1.5%–28.5%) after NC (P = 0.012). The survival curve shows that the overall survival for the NCI group has a better trend than that of the NC group, but there is no significant difference (P=0.193). The incidence of all-grade adverse events was greater in the NCI group than in the NC group (80.4% vs. 64.0%). The incidence of grade ≥3 adverse events was 10.9% (n=5) and 8.0% (n=2), respectively; however, these differences were insignificant.ConclusionsNCI is more effective and safer for patients with potentially resectable stage IIIA/IIIB NSCLC. Compared with NC alone, NCI significantly improves the pathological response and DFS without increasing adverse events.
IgG4-mediated M2 macrophage polarization in tertiary lymphoid structures of esophageal cancer: implications for immunosuppression
Authors: Wang Hui , Li Jirui , Wang Yinghai , Chen Yang , Zhang Weifeng , Pan Xinyan , Su Chanjuan , Li Ziteng , Wang Li , Gu Jiang 
Published: January 2025

BackgroundOur previous research highlighted the potential role of immunoglobulin G4 (IgG4) in mediating immunosuppression within the tumor microenvironment (TME). Tertiary lymphoid structures (TLS) in the TME have important immune-related functions. This study aims to analyze the distribution characteristics of IgG4-expressing cells, regulatory T cells (Tregs), and M2-type macrophages as well as to elucidate the relationship between IgG4 and the polarization of M2 macrophages within TLS in esophageal cancer.ObjectTo elucidate the distribution of IgG4, Treg cells, and M2 macrophages in TLS and to assess the impact of IgG4 on macrophage polarization.MethodsEsophageal cancer tissue were analyzed with multiplex immunofluorescence to determine the spatial distribution and density of B cells, T cells, and their subtypes. The relationship between IgG4 and CD8+ T cells in TLS, along with interleukin-10 (IL-10) expression and Treg presence, was studied. Serum IgG4 and IL-10 levels were compared between patients and healthy controls. In vitro, the impact of IgG4 on monocyte differentiation into M2 macrophages was observed.ResultsIgG4 density was inversely related with CD8+ T cells in mature TLS indicating a potential immunosuppressive role (P&lt;0.05,*). Serum analysis revealed that both IgG4 (P&lt;0.01, **) and IL-10 (P&lt;0.0001, ****) were significantly elevated and positively correlated in tumor patients compared to controls (P&lt;0.01, **). In vitro experiments confirmed that IgG4 monocyte differentiation into M2 macrophages, potentially enhancing the immunosuppressive phenotype in TLS.ConclusionIgG4 and IL-10 may contribute to immunosuppression in esophageal cancer by promoting the polarization of M2 macrophages within TLS, which could be a therapeutic target.