bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of dyslipidemia with lumbar disc herniation: A case-control study
Authors: Tan Bing , Xiang Shan-Lin , Hu Zhen-Ming , Zheng Yu-Hao , Ouyang Jian-yuan 
Published: July 2023

Abstract
Purpose: The purpose of this study was to investigate the relationship between dyslipidemia and lumbar disc herniation (LDH).
Methods: A total of 269 patients with LDH and 269 patients with lumbar vertebral fracture (LVF) were enrolled in this study. The total cholesterol level (TC), Low-density lipoprotein-cholesterol level (LDL-C), triglyceride level (TG), High-density lipoprotein-cholesterol level (HDL-C), nonHDL-C, ApoB level, ApoB A1 level and arteriosclerosis index (AI) were measured.The 269 patients with single-level LDH underwent surgery were enrolled as the disc herniation group and 269 patients who underwent surgical treatment for spine fracture(Pfirrmann Grading Systems of Grade I or II) during the same period were enrolled as the control group. The participants in the control group were selected randomly and matched for age (within 5 years) and sex.
Results: In this analysis, we found that the level of TC, TG, LDL, nonHDL-C, APOB, and APOA1 in patients with LDH was significantly higher compared with that of the controls. The proportion of high TC, borderline high-total cholesterol, high LDL-C,high TG, borderline high LDL-C, high APO B, high AI and high ApoB/ApoA1 in the LDH group was significantly higher relative to that of the control group. The ratio of TC/HDL-C, TG/HDL-C, LDL-C/HDL-C, nonHDL-C/HDL-C and ApoB/ApoA1 in the LDH group was significantly higher compared with that of the control group. Multivariate logistic regression analysis indicated that the levels of serum LDL-C, TC, TG, nonHDL-C, Apo B and AI were positively associated with the risk of LDH and were independent risk factors predicting LDH development.
Conclusion: Overall, this study indicates that TC, TG, LDL-C, nonHDL-C, Apo B, and AI levels in may increase the risk of LDH.Dyslipidemia may be associated with cartilage endplate (CEP) degeneration and hence may be involved in the pathological process of intervertebral disc degeneration (IVDD). Moreover, dyslipidemia may be a useful predictor of IVDD.
Dissecting fibroblast growth factor-induced endocrine therapy resistance in breast cancer cells
Authors: Altelaar Maarten , Veth Tim , Piskopou Anastasia 
Published: July 2023

Abstract
The main challenge of effectively treating estrogen receptor-positive breast cancer is overcoming endocrine therapy resistance initiated by fibroblast growth factor signaling. Fibroblast growth factor-induced resistance can completely inhibit a therapeutic response to endocrine therapy, such as induced by the estrogen degrader Fulvestrant. Evidently, this sharply decreases a patient’s chance of survival. While fibroblast growth factor signaling is known to play an important role in endocrine therapy resistance, the molecular mechanisms driving this process remain unknown. Here, we expose alterations in signaling that are involved in treatment resistance by monitoring system-wide changes in the (phospho)proteome, and activation of the kinome, upon FGF-induced endocrine therapy resistance in breast cancer cells. We show that FGF treatment effectively degrades the estrogen receptor, likely via the transcription factor TWIST1, while initiating various phosphorylation-driven pathways that are known to support cell survival. Our data further indicate involvement of apoptosis inhibition through BAD activation, and AP-1 transcription factor activity mediated by JUN phosphorylation. In addition, our data reveals involvement of the transcription factor ENO1, which protein abundance anti-correlates with ER levels, in FGF-induced endocrine therapy resistance. The observed co-regulation of ENO1 with MYC indicates that its function in regulating cellular metabolism is driving this contribution to resistance. Altogether, our data provides a system-wide insight into FGF-induced resistance and can contribute to novel treatment options for endocrine therapy resistance in breast cancer patients.
Survival benefits of interventional radiology and surgical teams collaboration during primary trauma surveys: a single-centre retrospective cohort study
Authors: Okada Ichiro , Hifumi Toru , Yoneyama Hisashi , Inoue Kazushige , Seki Satoshi , Jimbo Ippei , Takada Hiroaki , Nagasawa Koichi , Kohara Saiko , Hishikawa Tsuyoshi , Shiojima Hiroki , Hasegawa Eiju , Morimoto Kohei , Ichinose Yoshiaki , Sato Fumie , Kiriu Nobuaki , Matsumoto Junichi , Yokobori Shoji 
Published: July 2023

Abstract
Background
A team approach is essential for effective trauma management. Close collaboration between interventional radiologists and surgeons during the initial management of trauma patients is important for prompt and accurate trauma care. This study aimed to determine whether trauma patients benefit from close collaboration between interventional radiology (IR) and surgical teams during the primary trauma survey.
Methods
A retrospective observational study was conducted between 2014 and 2021 at a single institution. Patients were assigned to an embolization group (EG), a surgery group (SG), or a combination group (CG) according to their treatment. The primary and secondary outcomes were survival at hospital discharge compared with the probability of survival (Ps) and the time course of treatment.
Results
The analysis included 197 patients, consisting of 135 men and 62 women, with a median age of 56 [IQR, 38–72] years and an injury severity score of 20 [10–29]. The EG, SG, and CG included 114, 48, and 35 patients, respectively. Differences in organ injury patterns were observed between the three groups. In-hospital survival rates in all three groups were higher than Ps. In particular, survival in the CG was 15.5% higher than the Ps (95% CI: 7.5–23.6%; p < 0.001). In the CG, the median time for starting the initial procedure was 53 [37–79] min and the procedure times for IR and surgery were 48 [29–72] min and 63 [13–48] min, respectively. Those times were significantly shorter between three groups.
Conclusion
Close collaboration between IR and surgical teams, including the primary survey, improves the survival of severe trauma patients who require both IR procedures and surgeries by improving appropriate treatment selection and reducing the time process.
The impact of Internet development on carbon emission efficiency of industrial sector: the threshold effect ofmultiple environmental regulations
Authors: baitong Li , jian Li , Yan Tang 
Published: July 2023

Abstract
Under the background of carbon emission constraint and Industrial intelligent transformation, the extent to which Internet development affects the carbon emission efficiency of industrial sector (CEEI) has been increasingly focused. Using China’s provincial data during the period of 2011 to 2020, this study illustrates the impact of Internet development on CEEI and the role of different types and intensities of environmental regulatory tools in the relationship. The following conclusions could be drawn from this study. (1) Internet development will promote the CEEI. And the relationship is influenced by multiple environmental regulations, namely, command-controlled environmental regulation (CER), market-incentive environmental regulation (MER) and voluntary public participation environmental regulation (VER). For the whole sample, the enhancement effect of Internet development across the CER threshold on CEEI is weakened. when MER is between its two thresholds, the boost effect will be greatest. And under the VER threshold effect, the relationship presents an inverted U-shaped. (2) Heterogeneity analysis shows that the influence of Internet development on CEEI varies in different regions under the threshold of three types of environmental regulation tools. Therefore, the government should implement a diversified portfolio of environmental regulation policies, and give full play to the maximum effect of Internet development on CEEI promotion according to regional characteristics, thereby promoting industrial green transformation and upgrading.
Fibroblast growth factor receptor 2 (FGFR2), a new gene involved in the genesis of Autism Spectrum Disorder
Authors: Nicotera Antonio Gennaro , Amore Greta , Saia Maria Concetta , Vinci Mirella , Musumeci Antonino , Chiavetta Valeria , Federico Concetta , Spoto Giulia , Saccone Salvatore , Rosa Gabriella Di , Calì Francesco 
Published: July 2023

Abstract
Autism Spectrum Disorder (ASD) is a long known complex neurodevelopmental disorder, and over the past decades, with the enhancing of the research genomic techniques, has been the object of intensive research activity. This has aimed to unravel the potential causative factors underpinning its clinical and etiological heterogeneity and allowing our better understanding of the genetic causes of the disease and to find common genetic risk variants. Today, many genes involved in the development and functioning of the central nervous system have been related to ASD genesis. Herein, we report a 12-year-old Sicilian male diagnosed with severe ASD carrying a novel G>A de novo variant in the FGFR2 gene (NM_000141.5:c.412G>A) at the 138th codon (NP_000132.3:p.Asp138Asn). FGFR2 encodes for the ubiquitous fibroblast growth factor receptor (FGFR) type 2, a tyrosine kinase receptor implicated in several biological processes. The mutated version of this protein is known to be responsible for several variable overlapping syndromes. Even if there still is only sparse and anecdotal data, recent research highlighted a potential role of FGFR2 on neurodevelopment, and our finding provides new insights into the potential causative role of FGFR2 in complex neurodevelopmental disorders, and we propose FGFR2 as a new potential ASD-related gene.
Immunogenomic determinants of exceptional response to immune checkpoint inhibition in renal cell carcinoma
Authors: Shukla Sachet , Jammihal Tejas , Saliby Renée-Maria , Labaki Chris , Soulati Hanna , Gallegos Juan , Cuesta Arnau Peris , McCurry Dustin , Yu Chunlei , Shah Valisha , Poduval Deepak , Zarif Talal El , Ahmar Nourhan El , Laimon Yasmin , Eid Marc , Heng Daniel , Casellas Rafael , Rai Kunal , Millward Niki Zacharias , Msaouel Pavlos , Karam Jose , Signoretti Sabina , Allen Eliezer Van , Choueiri Toni , Braun David 
Published: July 2023

Abstract

Although immune checkpoint inhibitors can lead to “exceptional”, durable clinical responses in a subset of patients, the molecular mechanisms underlying exceptional responses (ERs) are still unknown. We analyzed pre-therapy genomic and transcriptomic data in treatment-naive patients with mccRCC treated with standard-of-care immunotherapies: (1) combination of PD-1/PDL1 and CTLA-4 (IO/IO), or (2) PD-1/PD-L1 inhibitor and VEGF-receptor inhibitor (IO/VEGF) combination. In the IO/IO cohort, clonal neoantigen load was significantly higher in ER patients. In the IO/VEGF cohort, ER patients displayed strong enrichment of B-cell receptor signaling related pathways, tertiary lymphoid structure (TLS) signatures, and evidence of increased metabolic activity. Our results suggest that ER may be related to clonal neoantigen-driven cytotoxic T-cell responses and TLS formation in tumor microenvironments. We conclude that novel therapeutic combinations that elicit both T- and B-cell directed anti-tumor immunity may be important to achieve exceptional benefit to IO-based treatment in ccRCC.
Severe pneumonia with co-infection of H5N1 and SARS-CoV-2: a case report
Authors: Jin Ke , Dai Zixing , Shi Ping , Li Yuwen , Zhu Chuanlong 
Published: July 2023

Abstract
Background H5N1 influenza is a cause of severe pneumonia. Co-infection with influenza and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may lead to poor prognosis in the epidemic of COVID-19. However, few studies have reported regarding patients co-infected with avian influenza and SARS-CoV-2.
Case presentation A 52-year-old woman presented with fever for eight days and worsening shortness of breath and decreased blood pressure. Computed tomography (CT) revealed air bronchogram, lung consolidation and bilateral pleural effusion. Furthermore, polymerase chain reaction (PCR) of the bronchoalveolar lavage fluid (BALF) showed positivity for H5N1 and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
Conclusion H5N1 influenza is a cause of severe pneumonia. The clinical presentation of the patient had a predomination of H5N1 influenza rather than COVID-19. A viral PCR analysis is necessary to demonstrate the pathogen of severe pneumonia. The patient exhibited an excellent prognosis upon the appropriate use of antiviral medicine.
Stratigraphic framework of pulsed volcanism in central Ethiopian plateau
Authors: Ayalew Dereje , Sefa Faysel , Pik Raphaël , Abebe Bekele , Getaneh Worash , Atnafu Balemwal 
Published: July 2023

Abstract
This paper presents new stratigraphic correlation and naming for younger basalt lavas (<24 Ma) and enclosed rhyolites near the intersection of the southern Red Sea rift and the Ethiopian rift valley, based upon three volcano-stratigraphic sections located over about 30 kilometres, and they bracket the timing of eruption of the upper sequence with existing geochronology. The correlations are based on the petrography (thin sections) of ca. 32 samples taken from these three sections, combined with outcrop description. The stratigraphy is proposed as 5 new formations, partially placed into an existing stratigraphic framework, based on the dominant unit-basalt or rhyolite in the package of sequences. These new stratigraphic columns also include non-volcanic units (interlayered sedimentary strata, paleosols and weathering surfaces), which are not usually described in the volcanic pile, showing that there was more complexity in this succession than previously known. This new stratigraphic framework will encourage more geochronology and geochemistry studies that are sorely needed.
Fetching Felines: A Survey of Cat Owners on the Diversity of Cat (Felis catus) Fetching Behaviour
Authors: Forman Jemma , Renner Elizabeth , Leavens David 
Published: July 2023

Abstract
Domesticated animals are famous for the ease with which they can accommodate to diverse human environments and roles, but less well-studied is the ease with which domestic animals can manipulate their human caregivers to their own ends. Here we present the results of a survey of 924 cat owners who report fetching behaviour in 1,154 cats. The overwhelming majority (94.4%) of these owners report that fetching emerged in the absence of explicit training. Fetching was primarily first noticed when the cats were less than one year old (n = 701) or 1 to 7 years old (n = 415). Cats initiated and terminated fetching bouts more often than did their owners. Thus, cats who fetch demonstrate independent and co-ordinated agency in the onset and maintenance of fetching behaviour with their human partners. Additional findings highlight the diversity of objects fetched and the diversity in household demographics. Our thematic analysis reveals owners’ perspectives on (a) the process of a fetching session, (b) the initial acquisition of fetching, and (c) the circumstantial factors that influence fetching patterns. In summary, cats who fetch largely determine when they engage in fetching sessions and actively influence the play behaviour of their owners.
A new large-scale gravitational complex discovered in the Squillace Embayment (central Mediterranean): Tectonic and geohazard implications
Authors: Mangano Giacomo , Ceramicola Silvia , Alves Tiago , Zecchin Massimo , Civile Dario , Ben Anna Del , Critelli Salvatore 
Published: July 2023

Abstract
Seismic reflection (2D/3D), borehole and bathymetric data have led to the recognition of a new gravitational complex in the Squillace Embayment. Named as Squillace Complex, it has a NE-striking headwall connected to a basal detachment zone formed between Messinian evaporites and Tortonian shales. Its geometry changes to a W to E predominant movement in its toe region. The Squillace Complex is marked by the presence of sinuous and continuous seafloor scarps just a few kilometers offshore (minimum distance 1.5 km), which occur over a lobate-shaped elongated morphological high. Seismic-well ties show that the complex initiated its movement in the Zanclean and continued for ~ 2 Ma into the Gelasian, with an average rate of 1.6 mm /y. Movement ceased in the Calabrian but resumed soon later during Middle Pleistocene, until the present day, at a relative slower rate of 0.4 mm/y. The onset of gravitational collapse in the Squillace Complex is correlated with discrete contractional/transpressional events, under episodes of basin shortening and temporary stopping of Calabrian Arc migration, as well as during episodes of tectonic uplift after 0.45 Ma. Conversely, its arrest during the Calabrian is linked to slab rollback and subduction of the Ionian plate under the arc.
Analysis of spatiotemporal variations in b-values before the 6.8-magnitude earthquake in Luding, Sichuan, China, on September 5, 2022
Authors: Li Qidong , Xie Zhuojuan 
Published: July 2023

Abstract
Using the earthquake catalog provided by the Sichuan Earthquake Network Center, spatial and temporal b-value scans were calculated for large- and small-scale regions based on assessing the completeness of the earthquake catalog and aftershock removal. The results show that (1) b-values in the large-scale region ranged from 0.689 to 1.169, with a mean value of 0.928, while the b-values in the small-scale region ranged from 0.694 to 1.223, with a mean value of 0.925. The b-values in the study area were below the mean value before the medium and strong earthquake occurrence, and all exhibited the anomalous feature of a sudden drop-low peak rise. (2) The sliding rate of the northwest section of the Xianshui River Fracture Zone was higher than that of the southeast section; therefore, a large amount of stress was accumulated in the mill-west section of the southeast section, leading to a 6.8-magnitude earthquake in Luding. Before the earthquake, the study area was a low b-value area. The b-value decreased within a short period after the earthquake, dividing the area into concave and convex bodies. This area still has a future risk of moderate to strong earthquakes. (3) The error in the b-values for most of the earthquakes in the large- and small-scale regions is between 0.05 and 0.15, and only individual grid points have larger b-value errors (>0.2), indicating high confidence in the information. In addition, when conducting a b-value study, choosing a suitable study area is important to avoid missing the b-value anomaly area.
Prognostic Value of the Preoperative Ratio of Fibrinogen to Prealbumin in Patients Undergoing Radical Resection for Lung Cancer
Authors: huang zhining , Wang Gaoxiang , Xu Liangdong , Cui Shijun , Sun Xiaohui , Li Tian , Wang Jun , Xu Meiqing , Xie Mingran 
Published: July 2023

Abstract
Background and Objective It has been proven that The ratio of fibrinogen to prealbumin (FPR) has a significant effect on the prognosis of gastric cancer, colorectal cancer, esophageal cancer and other malignant tumors, but there are few studies on its effect on the prognosis of patients with resectable non-small cell lung cancer. This study aims to analyze the relationship between FPR and the postoperative clinicopathologic features and prognosis of non-small cell lung cancer.
Methods The clinical follow-up pathological data of 289 patients who underwent radical resection of lung cancer and were confirmed as NSCLC by postoperative pathology were analyzed retrospectively, and the FPR values were calculated according to the serological test results within 1 week before surgery. The critical value of FPR (cut-off value) was obtained by analyzing the receiver operating characteristic curve (ROC). Kaplan-Meier survival curve and Cox proportional risk model were used to study the effect of FPR on the prognosis of patients with non-small cell lung cancer after surgery. Results 5-year survival was used as the end point to draw the ROC curve of the FPR value. When the FPR value was 10.96, the Youden index was the largest, the sensitivity was 62.4%, and the specificity was 69.6%. The cumulative five-year survival rate of the low FPR group was significantly higher than that of the high FPR group. Univariate and multivariate analysis showed that age, TNM stage and FPR level were significantly correlated with survival rate (P < 0.05).
Conclusion As a new inflammatory marker, the FPR level can effectively predict the prognosis of patients with non-small cell lung cancer after radical resection.
A collapse risk assessment method for subway foundation pit based on cloud model and improved Dempster-Shafer evidence theory
Authors: Wu Bo , Zeng Jiajia , Zhu Ruonan , Yang Fan , Liu Cong , Xie Yundong 
Published: July 2023

Abstract
Collapse is the main engineering hazard in the construction of open-cut foundation pit, and risk assessment is one of the important ways to reduce it. Aiming at the high conflicting evidence fusion failure, a fast convergence and highly reliable multi-data fusion method based on cloud model (CM) and improved Dempster-Shafer evidence theory is proposed, which can achieve accurate assessment of subway pit collapse risk. Firstly, CM is introduced to quantify the qualitative metrics. Then, A new correction parameter is defined for improving the conflicting among evidence bodies based on conflict degree, discrepancy degree and uncertainty, while a fine-tuning term is added to reduce the subjective effect of global focal element assignment. Finally, the risk level is obtained by the maximum affiliation principle. The method has been successfully applied to Luochongwei Station. The difference between the maximum value and the second largest value of the basic probability assignment is 0.624, and the global uncertainty degree is 0.087, both of which satisfy the decision evaluation condition, but other methods can only satisfy one or neither of them. And it requires only 5 cycles to reach the steady state by fusing data of the same index, which has faster convergence compared with other methods. The proposed method has good universality and effectiveness in subway pit collapse risk assessment.
Silicon nanocages as effective catalysts for oxygen reduction reaction
Authors: Yan Chuanyong , Wei Qing , Chen Qunyu , Zhang Lei 
Published: July 2023

Abstract
Here, the catalytic activity of Fe-C44 and Fe-Si44 for oxygen reduction reaction by effective mechanisms are examined. The nanocatalysts (Fe-C44 and Fe-Si44) for ORR mechanisms are suggested and results are compared with Pt-based catalysts. Results indicated that the H2O on surfaces of Fe-C44 and Fe-Si44 nanocages are physically absorbed and it means that H2O is easily desorbed from Fe-C44 and Fe-Si44 nanocages. The adsorption OOH on Fe-C44 and Fe-Si44 nanocages has higher Eadsorption than O2 adsorption and also dissociation of O2 molecules on Fe-C44 and Fe-Si44 nanocages has high activation barrier energy. The nanocage-*OH, nanocage-*OH and H2O and nanocage-*O and H2O formation are rate-determining steps in mechanisms 1, 2 and 3. It can be demonstrated that pathway 1 is effective mechanism for ORR on Fe-C44 and Fe-Si44 nanocages. Results shown that the overpotential of ORR on Fe-C44 and Fe-Si44 nanocages are lower than Pt catalysts.