bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Statistical Finite Element Method Integrating a Plurigaussian Random Field Generator for Multi-scale Modelling of Solute Transport in Concrete
Authors: Ricketts Evan John , Freeman Brubeck Lee , Cleall Peter John , Jefferson Anthony , Kerfriden Pierre 
Published: April 2023

AbstractA new model for the multi-scale simulation of solute transport in concrete is presented. The model employs plurigaussian simulations to generate stochastic representations of concrete micro- and meso-structures. These are idealised as two-phase medium comprising mortar matrix and pores for the micro-structure, and mortar and large aggregate particles for the meso-structure. The generated micro- and meso-structures are employed in a finite element analysis for the simulation of steady-state diffusion of solutes. The results of the simulations are used to calculate effective diffusion coefficients of the two-phase micro- and meso-structures, and in turn, the effective diffusion coefficient at the macro-scale at which the concrete material is considered homogenous. Multiple micro- and meso-structures are generated to account for uncertainty at the macro-scale. In addition, the level of uncertainty in the calculated effective diffusion coefficients is quantified through a statistical analysis. The numerical predictions are validated against experimental observations concerning the diffusion of chloride through a concrete specimen, suggesting that the generated structures are representative of the pore-space and coarse aggregate seen at the micro- and meso-scales, respectively. The method also has a clear advantage over many other structural generation methods, such as packing algorithms, due to its low computational expense. The stochastic generation method has the ability to represent many complex phenomena in particulate materials, the characteristics of which may be controlled through the careful choice of intrinsic field parameters and lithotype rules.
Circulating metabolites as potential biomarkers for the early detection and prognosis surveillance of gastrointestinal cancers
Authors: Song Guodong , Wang Li , Tang Junlong , Li Haohui , Pang Shuyu , Li Yan , Liu Li , Hu Junyuan 
Published: April 2023

Abstract
Background and aims
Two of the most lethal gastrointestinal (GI) cancers, gastric cancer (GC) and colon cancer (CC), are ranked in the top five cancers that cause deaths worldwide. Most GI cancer deaths can be reduced by earlier detection and more appropriate medical treatment. Unlike the current “gold standard” techniques, non-invasive and highly sensitive screening tests are required for GI cancer diagnosis. Here, we explored the potential of metabolomics for GI cancer detection and the classification of tissue-of-origin, and even the prognosis management.

Methods
Plasma samples from 37 gastric cancer (GC), 17 colon cancer (CC), and 27 non-cancer (NC) patients were prepared for metabolomics and lipidomics analysis by three MS-based platforms. Univariate, multivariate, and clustering analyses were used for selecting significant metabolic features. ROC curve analysis was based on a series of different binary classifications as well as the true-positive rate (sensitivity) and the false-positive rate (1-specificity).

Results
GI cancers exhibited obvious metabolic perturbation compared with benign diseases. The differentiated metabolites of gastric cancer (GC) and colon cancer (CC) were targeted to same pathways but with different degrees of cellular metabolism reprogramming. The cancer-specific metabolites distinguished the malignant and benign, and classified the cancer types. We also applied this test to before- and after-surgery samples, wherein surgical resection significantly altered the blood-metabolic patterns. There were 15 metabolites significantly altered in GC and CC patients who underwent surgical treatment, and partly returned to normal conditions.

Conclusion
Blood-based metabolomics analysis is an efficient strategy for GI cancer screening, especially for malignant and benign diagnoses. The cancer-specific metabolic patterns process the potential for classifying tissue-of-origin in multi-cancer screening. Besides, the circulating metabolites for prognosis management of GI cancer is a promising area of research.
Assessing the risks of capecitabine and its active metabolite 5-fluorouracil to freshwater biota
Authors: Venâncio Cátia , Monteiro Bruna , Lopes Isabel , Sousa Ana C. A. 
Published: April 2023

AbstractCapecitabine (CAP, prodrug) and 5-fluorouracil (5-FU, its active metabolite) are two of the most prominent cytostatics, for which no clear picture can be drawn regarding potential concentrations of effect for freshwater biota, with CAP being grouped in the least studied cytostatic, whereas 5-FU has been classified as of no and of high environmental risk. Accordingly, the present work aimed to assess the ecotoxicity of CAP and 5-FU in three freshwater species, which included a 72-h assay with the producerRaphidocelis subcapitata; a 96-h assay with the invertebrate secondary consumerHydra viridissima; and a 96-h assay with embryos of the vertebrate secondary consumerDanio rerio. The following endpoints were monitored: yield and population growth rate for the algae; mortality, morphological alterations, and post-exposure feeding rates for the cnidarian; and mortality, hatching, and malformations for the fish. Overall, organisms’ sensitivity to CAP decreased in the following order:R. subcapitata > H. viridissima > D. rerio, whereas for 5-FU, it decreased in the following order:H. viridissima > D. rerio > R. subcapitata. For CAP, no median lethal effective concentrations (LC/EC50) were possible to compute forD. rerio, with no significant mortality or malformations registered in embryos exposed at concentrations up to 800 mg L−1. ForR. subcapitata, the EC50s were 0.077 and 0.63 mg L−1for yield and growth rate, respectively, and forH. viridissima, the EC50,30 minfor feeding was 22.0 mg L−1. For 5-FU, no EC50scould be computed forR. subcapitata, whilst the EC50sforH. viridissimamortality and feeding were 55.4 and 67.9 mg L−1, respectively, and forD. rerio, the LC50,96 hand EC50,96 h(hatching and abnormalities) were 4546, 4100, and 2459 mg L−1, respectively. Assuming similar modes of action for both compounds and their co-occurrence, the combined risk quotient of the two chemicals was determined to be 7.97, which represents a risk for freshwater biota. Anticipating the increased consumption of these compounds and cancer development trends worldwide, these impacts may be further aggravated.
Selenium nanoparticles induce growth and physiological tolerance of wastewater‑stressed carrot plants
Authors: El-Batal Ahmed I. , Ismail Mohamed A. , Amin Mohamed A. , El-Sayyad Gharieb S. , Osman Mahmoud S. 
Published: April 2023

AbstractClimate changes have a direct impact on agricultural lands through their impact on the rate of water levels in the oceans and seas, which leads to a decrease in the amount of water used in agriculture, and therefore the use of alternative sources of irrigation such as wastewater and overcoming its harmful effect on plants was one of the solutions to face this problem. In the present study, the impacts of the synthesized selenium nanoparticles (Se NPs) alone or in combination with glycine betaine and proline treatments on the growth, physiological, and yield attributes of wastewater irrigated carrot plants are investigated. Furthermore, to evaluate heavy metals uptake and accumulation in edible plant parts. The usage of wastewater to carrot plants significantly increased free proline contents, total phenols, superoxide dismutase, catalase, peroxidase, polyphenol oxidase, Malondialdehyde (MDA), and hydrogen peroxide (H2O2) throughout the two growth stages. While total soluble carbohydrate and soluble protein content in carrot shoots and roots were significantly reduced. Moreover, the concentrations of nickel (Ni), cadmium (Cd), lead (Pb), and cobalt (Co) in carrot plants were considerably higher than the recommended limits set by international organizations. Application of selenium nanoparticles alone or in combination with glycine betaine and proline reduced the contents of Ni, Cd, Pb, and Co; free proline; total phenols; superoxide dismutase; catalase; peroxidase; polyphenol oxidase; Malondialdehyde (MDA) and Hydrogen peroxide (H2O2) in carrot plants. However, morphological aspects, photosynthetic pigments, soluble carbohydrates, soluble protein, total phenol, and β-Carotene were enhanced in response to Se NPs application. As an outcome, this research revealed that Se NPs combined with glycine betaine and proline can be used as a strategy to minimize heavy metal stress caused by wastewater irrigation in carrot plants, consequently enhancing crop productivity and growth.
Long-Term Training Increases Atrial Fibrillation Sustainability in Standardbred Racehorses
Authors: Carstensen Helena , Nissen Sarah Dalgas , Saljic Arnela , Hesselkilde Eva Melis , van Hunnik Arne , Hohl Mathias , Sattler Stefan Michael , Fløgstad Cecilie , Hopster-Iversen Charlotte , Verheule Sander , Böhm Michael , Schotten Ulrich , Jespersen Thomas , Buhl Rikke 
Published: April 2023

Abstract
Atrial fibrillation (AF) is more prevalent in athletes, and currently, the mechanisms are not fully understood. Atrial fibrillation inducibility and stability was investigated in trained and untrained Standardbred racehorses. The horses underwent echocardiography for evaluation of atrial size. High-density mapping during AF was performed, and the presence of structural remodeling, as well as the expression of inflammatory and pro-inflammatory markers in the atria, was studied. Atrial fibrillation sustained significantly longer after tachypacing in the trained horses, whereas no difference in AF inducibility was found. The untrained horses displayed a significant difference in the AF complexity when comparing right and left atria, whereas such difference was not observed in the trained animals. No evidence of increased structural remodeling or inflammation could be identified. Left atrial dimensions were not significantly increased. The increased AF sustainability in trained horses was not related to fibrosis or inflammation as seen in other animal exercise models.
Graphical abstract
Investigation of X-band and Ka-band amplitude scintillation based on measurement data collected during ESA’s BepiColombo superior solar conjunction campaign
Authors: Chen Shun-Ping , Lanucara Marco , Villalvilla Jose 
Published: April 2023

AbstractSolar phase scintillation and solar amplitude scintillation are fundamentally important in deep space mission operations for designing a communication system capable of transmitting signals when the signal path is close to the Sun. The ESA’s BepiColombo measurement data were analyzed in a previous paper in terms of the power spectral density of the solar phase scintillation, also with a comparison with Woo’s solar phase scintillation theory, when X-band and Ka-band signals propagate close to the Sun with a small Sun-Earth-Probe (SEP) angle during the superior solar conjunction campaign in March 2021 in its cruise phase to Mercury. In this paper the solar amplitude scintillation is analyzed both by calculating the power spectral density and the scintillation index. The results of scintillation index, derived from these measurement data, fit the NASA JPL’s scintillation index model.
Applying the ‘Candidacy’ Model to understand access to key nutrition, food & health services in LMIC contexts: a qualitative study in Odisha, India
Authors: Mitchell Rebecca , Gordon Jessica , Bhoi Gopal Krushna , Nisbett Nicholas 
Published: April 2023

Abstract
In order to make progress towards Sustainable Development Goal 2 – Zero Hunger - we must acquire a better understanding of what continues to hamper achieving food security, particularly in contexts where progress has been achieved, but has then faltered. This article investigates access to nutrition and food services in three of the Indian state of Odisha’s traditionally poorer districts, where a large number of the state’s most marginalised populations live. Semi-structured interviews were carried out in 11 villages. The Dixon-Woods Candidacy Model was employed to provide greater insight into the experiences of access to health and nutrition services, from both the supply and the demand sides. We found that there are many points along the journey that hamper access. We identified two levels of gatekeepers that can create (or remove) barriers, the first as front-line service providers and the second as high-level officials. The candidacy model shows that marginalisation caused by identity, poverty and education disparities hampers progress throughout this journey. This article aims to provide a view to improve our understanding of access to health, food and nutrition services, to improve food security, and to show the value of the candidacy model applied to an LMIC health setting.
The Relationship Between Health Expenditure, CO2 Emissions, and Economic Growth in G7: Evidence from Heterogeneous Panel Data
Authors: Dritsaki Melina , Dritsaki Chaido 
Published: April 2023

AbstractΤhe current paper examines the relationship between per capita health care expenditures, per capita CO2 emissions, and per capita gross domestic product (GDP) in G7 countries. At the beginning, we examine the cross-sectional dependence and the slope homogeneity between the countries. Then, the second-generation unit root test is applied using the Pesaran, CIPS (2007) test, while for the cointegration test, the Westerlund (Oxford Bulletin of Economics and Statistics 69(6):709-748, 2007) test was applied. The long -run panel cointegration coefficients were analyzed with the augmented mean group (AMG) estimators, which allow the cross-sectional dependence and heterogeneity. Finally, the test by Dumitrescu and Hurlin (Economic Modelling 29(4):1450-1460, 2012) was used in order to check for causality taking into account the heterogeneity and cross-sectional dependence on panel data. The preliminary analyses show that variables are cross-sectional-dependant and heterogenous and are first-order stationary. Cointegration test by Westerlund (Oxford Bulletin of Economics and Statistics 69(6):709-748, 2007) which allows heterogeneity and cross-sectional dependence show that there is a stable and long-run relationship between variables. Moreover, the long-run coefficients which were estimated with the AMG approach are found to be statistically significant and positive for the GDP per capita, and negative in the case of greenhouse gas emissions per capita. Finally, causality test by Dumitrescu and Hurlin (Economic Modelling 29(4):1450-1460, 2012) revealed a unilateral causality from greenhouse gas emissions per capita towards health expenditure per capita for all G7 countries.
Arthur Marble Aquifer and Te Waikoropupu Springs, New Zealand: flow contributions and nitrate sources
Authors: Williams Paul W. 
Published: April 2023

AbstractThis paper investigates sources of early signs of nitrate pollution in a karst aquifer and major karst spring. Te Waikoropupu Springs are the largest springs in New Zealand and amongst the largest in the Southern Hemisphere with a mean outflow of 13.4 m3/s. They discharge the clearest water ever recorded from a karst spring, but early warning of water quality deterioration is signalled by increasing nitrate concentrations. The springs discharge water from a partly artesian aquifer of 2.85 km3 volume in karstified Ordovician marble with a transmission time averaging 7.9 years. Reservoir porosity is unusually high for a crystalline carbonate rock, estimated as 6%. Water emerging at Main Spring (9.89 m3/s) and adjacent Fish Creek Springs (3.48 m3/s) is a mix of recharge from four main sources. The paper investigates by means of mass balance modelling the proportions of water coming from each source, the origins of nitrate contamination and the contribution of nitrification. Water losses into the bed of the upper Takaka River, about 17 km from the Springs, provide 13% of the mean flow at Main Spring, 34% of the flow at Fish Creek Springs, and 83% of the volume discharged at submarine springs. Infiltration from rain falling over farmed land in the middle valley is estimated to supply 10% of total outflow at Main Spring and Fish Creek Springs but to contribute 82% of the NO3-N output discharged at the springs. Nitrification accounts for 16% of the nitrate discharged. A 34% reduction of leachate concentration in the middle valley would be required to bring NO3-N values at Main Spring back to levels recorded in the 1970s.
HAkAu: hybrid algorithm for effective k-automorphism anonymization of social networks
Authors: Medková Jana , Hynek Josef 
Published: April 2023

AbstractOnline social network datasets contain a large amount of various information about their users. Preserving users’ privacy while publishing or sharing datasets with third parties has become a challenging problem. The k-automorphism is the anonymization method that protects the social network dataset against any passive structural attack. It provides a higher level of protection than other k-anonymity methods, including k-degree or k-neighborhood techniques. In this paper, we propose a hybrid algorithm that effectively modifies the social network to the k-automorphism one. The proposed algorithm is based on the structure of the previously published k-automorphism KM algorithm. However, it solves the NP-hard subtask of finding isomorphic graph extensions with a genetic algorithm and employs the GraMi algorithm for finding frequent subgraphs. In the design of the genetic algorithm, we introduce the novel chromosome representation in which the length of the chromosome is independent of the size of the input network, and each individual in each generation leads to the k-automorphism solution. Moreover, we present a heuristic method for selecting the set of vertex disjoint subgraphs. To test the algorithm, we run experiments on a set of real social networks and use the SecGraph tool to evaluate our results in terms of protection against deanonymization attacks and preserving data utility. It makes our experimental results comparable with any future research.
Farmers’ perception and management of water scarcity in irrigated rice-based systems in dry climatic zones of West Africa
Authors: Johnson Jean-Martial , Becker Mathias , Dossou-Yovo Elliott Ronald , Saito Kazuki 
Published: April 2023

AbstractWater scarcity threatens irrigated agriculture in sub-Saharan Africa (SSA). Knowledge of farmers’ perceptions and drivers for decision-making in view of coping with water scarcity is so far lacking but needed to improve local technologies and frame policies fostering their adoption. Here, for the first time, we investigated farmers’ perception of water scarcity, key adaptation strategies, and the determinants of their adoption in irrigated rice schemes in dry climatic zones of West Africa. We surveyed 572 farming households and conducted expert interviews with key informants in four contrasting irrigated rice schemes in Burkina Faso between April 2018 and August 2019. Information was gathered on biophysical field characteristics, grain yields, agronomic and water management practices, farmers’ perception of water scarcity, their adaptive responses, and social-economic attributes of adopting households. Nearly 80% of the respondents reported having experienced water scarcity during the past 5 years. To cope with the adverse effect of water scarcity, farmers implemented seventeen different adaptation strategies that could be categorized into seven groups. Most popular among those were “water and soil conservation practices” (consisting mainly of field bunding and leveling), “no rice cultivation,” and “crop rotation.” Farmers in drier areas (Sudano-Sahelian zone) were less likely to adopt and implement several adaptation strategies to water scarcity compared to farmers in wetter areas (Sudanian zone). Belonging to farming associations increased the probability of implementing several strategies to alleviate water scarcity, while female-headed households tended to have a lower propensity to adopt and implement concomitantly several adaptation strategies in comparison with their male counterpart. The dissemination of scheme- and household-specific technology options could contribute to mitigating water scarcity in irrigated rice-based systems in the dry climatic zones of West Africa, thus contributing to rural livelihood and food security.
Fostering Computational Thinking and Social-emotional Skills in Children with ADHD and/or ASD: a Scoping Review
Authors: Oswald Christina , Paleczek Lisa , Maitz Katharina , Husny Maximilian , Gasteiger-Klicpera Barbara 
Published: April 2023

Abstract
Although Computational Thinking (CT) is considered an essential 21st century skill, little is known about teaching CT to students with autism spectrum disorder (ASD) and/or attention deficit/hyperactivity disorder (ADHD). To address this gap in the research, we conducted a scoping review to identify those approaches promoting programming skills and/or CT in children aged 6–15 with ASD and/or ADHD. We also investigated which other skills were simultaneously fostered and examined the challenges and benefits reported in the interventions undertaken. Results indicate that fostering programming and/or CT in students with ASD and/or ADHD has a beneficial effect. CT-related skills acquired by such students were found to persist beyond the intervention period and were often associated with an improvement in student social-emotional competences.
Narratives as a Tool for Practically Wise Leadership
Authors: Bostanli Lu , Habisch Andre 
Published: April 2023

AbstractRecent studies have identified practical wisdom as a critical area for exploration in the domains of management and leadership. This paper delves into the cultivation and manifestation of practical wisdom in leadership, emphasizing the potential of narratives as an efficacious tool, as corroborated by academic literature. Employing practical wisdom theory and a refined analytical model, we examine the role of narratives as a key instrument for practically wise leaders. Through the provision of theoretical underpinnings and empirical evidence, our study seeks to elucidate the tripartite interconnectedness of practical wisdom, narratives, and leadership. Subsequently, a conceptual model is developed and illustrated, outlining the relationship between narratives and practical wisdom across diverse leadership contexts. This analysis positions practical wisdom as a fundamental guidance for leaders’ narrative practices. Acknowledging the paper’s conceptual focus, we discuss the practical and theoretical implications of the proposed model and advocate for empirical inquiry to further enhance understanding of narrative practices in practically wise leadership.