bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hepatocellular carcinoma surveillance in the telehealth era: A single-centre review
Authors: Hui Samuel , Sane Nikhita , Wang Andrew , Wan Leo , Bell Sally , Le Suong , Dev Anouk 
Published: April 2023

Background Real-world hepatocellular carcinoma (HCC) surveillance uptake remains suboptimal, despite evidence that surveillance is associated with lower cancer-related mortality in patients with cirrhosis and chronic hepatitis B. We aimed to examine the impact of telehealth consultations on HCC surveillance rates within a specialist liver clinic. Methods We conducted a retrospective observational study within an Australian outreach liver clinic within a culturally diverse community, comparing standard consultations before the COVID-19 pandemic to telehealth consultations during the pandemic. The primary outcome was surveillance uptake defined as the percentage of time up-to-date with surveillance (PTUDS) with the 6-month interval following each scan considered up-to-date. Results Over 18 months of follow-up for each cohort, the median PTUDS was 86.5% in the standard consultation cohort and 85.5% in the telehealth consultation cohort ( p = 0.12). HCC diagnoses did not differ between groups and hospitalisation and mortality rates were low. Using multivariate regression, increasing age, the need for an interpreter and being born in South-East Asia independently predicted PTUDS in the standard consultation cohort, whereas being born in Australia or New Zealand was predictive of a lower PTUDS. Current alcohol use and distance from the clinic predicted a lower PTUDS in the telehealth consultation cohort. In both groups, missed clinic attendances were strongly predictive of a lower PTUDS. Conclusion Telehealth hepatology consultations effectively coordinate HCC surveillance and are associated with similar outcomes to standard consultations. Its implementation should be widely considered given its advantages with regards to accessibility for patients.
Variable dysregulation of circulating lipocalin-2 in different obese phenotypes: Association with vasodilator dysfunction
Authors: Schinzari Francesca , Vizioli Giuseppina , Campia Umberto , Cardillo Carmine , Tesauro Manfredi 
Published: April 2023

Background: Obesity is linked with heightened cardiovascular risk, especially when accompanied by metabolic abnormalities. Lipocalin (LCN) 2 and retinol-binding protein (RBP) 4, two members of the lipocalin family, may be upregulated in insulin resistance and atherosclerosis. We analyzed whether changes in circulating LCN2 and RBP4 in obese individuals relate with impaired vasodilator reactivity, an early stage in atherosclerosis. Methods: Obese individuals ( n = 165), without ( n = 48) or with ( n = 117) metabolic abnormalities, and lean subjects ( n = 42) participated in this study. LCN2 and RBP4 were measured by Luminex assay. Endothelium-dependent and -independent vasodilation to acetylcholine and sodium nitroprusside, respectively, was assessed by strain-gauge plethysmography. Results: Circulating LCN2 was higher in obese than in lean subjects ( p < 0.001), whereas RBP4 was not different between the two groups ( p = 0.12). The vasodilator responses to both acetylcholine and nitroprusside were impaired in obese individuals ( p < 0.001 vs lean subjects), with no difference between those with metabolically healthy or unhealthy obesity ( p > 0.05). In the whole population, vasodilator responses to acetylcholine ( R = 0.23, p = 0.01) and nitroprusside ( R = 0.38, p < 0.001) had an inverse, linear relationship with circulating LCN2; no correlation, by contrast, was observed between circulating RBP4 and vasodilator reactivity (both p > 0.05). In a subgroup of obese patients with diabetes ( n = 20), treatment with metformin ( n = 10) or pioglitazone ( n = 10) did not modify circulating LCN2 and RBP4 or vascular reactivity (all p > 0.05). Conclusions: Circulating LCN2, but not RBP4, is higher in obese than in lean individuals. Interestingly, changes in LCN2 inversely relate to those in vasodilator function, thereby making this protein a potential biomarker for risk stratification in obesity.
Preprocedural imaging modalities in patients undergoing iliocaval venous recanalization and stent placement
Authors: Müller Markus , Wolf Florian , Loewe Christian , Beitzke Dietrich , Zehetmayer Sonja , Gschwandtner Michael E , Willfort-Ehringer Andrea , Koppensteiner Renate , Schlager Oliver 
Published: April 2023

Purpose: To determine the diagnostic accuracy of preinterventional imaging modalities in patients being evaluated for iliocaval venous recanalization and stent placement. Methods: Consecutive patients with iliocaval postthrombotic obstructions or nonthrombotic iliac vein lesions (NIVL), who were scheduled for recanalization, underwent duplex ultrasound (DUS), magnetic resonance venography (MRV), multiplanar venography (MPV), and intravascular ultrasound (IVUS). The diagnostic accuracies of DUS, MRV, and MPV were analyzed using IVUS as reference. Results: A total of 216 limbs in 108 patients (80 patients with postthrombotic obstructions, 28 patients with NIVL) were examined. In patients with postthrombotic obstructions, the diagnostic sensitivities for the detection of lesions of the common femoral vein were 81% (95% CI 71–89%) for DUS, 76% (95% CI 65–85%) for MRV, and 86% (95% CI 76–93%) for MPV. The sensitivities for detecting lesions of the iliac veins were 96% (95% CI 89–99%) for DUS, 99% (95% CI 92–100%) for MRV, and 100% (95% CI 94–100%) for MPV. Regarding the inferior vena cava, the sensitivities were 44% (95% CI 24–65%) for DUS, 52% (95% CI 31–73%) for MRV, and 70% (95% CI 47–86%) for MPV. The sensitivities for detecting NIVL were 58% (95% CI 34–79%) for DUS, 90% (95% CI 68–97%) for MRV, and 95% (95% CI 73–99%) for MPV. Conclusion: In patients scheduled for recanalization of iliocaval postthrombotic obstructions, the sensitivities of DUS, MRV, and MPV were similar. In patients with suspected inferior vena cava involvement and in patients with NIVL, additional imaging with MR or conventional venography is required.
Psychoeducational and motivational treatment for low-weight Avoidant/Restrictive Food Intake Disorder (ARFID): Three case reports in school-aged children
Authors: Datta Nandini , Matheson Brittany , Walker Avery Carter , Van Wye Eliza , Lock James D 
Published: April 2023

Background Individuals with Avoidant/Restrictive Food Intake Disorder (ARFID) experience restrictive or highly selective eating problems that interfere with growth and development. Despite the increasing number of referrals for ARFID, no evidence-based treatments exist. This compilation of case composites describes a novel manualized treatment, Psychoeducational and Motivational Treatment (PMT) for children with ARFID, focusing on exploring motivation to change eating behaviors. This approach is based on motivational non-directive psychotherapy models, psychoeducational interventions, and the usefulness of play to support psychotherapeutic learning in school-age children. Case Presentations Three cases of children with ARFID treated using PMT are presented: a 7-year-old, a 10-year-old, and a 12-year-old. These cases illustrate how a clinician delivers PMT interventions in the context of developmental abilities and common comorbidities associated with ARFID. Conclusion PMT is a promising therapy for ARFID in school-age children. Challenges and strategies are discussed, including ways to address obstacles such as young age, comorbidities, and use of the virtual environment.
Towards more comprehensive nationwide familial aggregation studies in Denmark: The Danish Civil Registration System versus the lite Danish Multi-Generation Register
Authors: Due Jeppe Klok , Pedersen Marianne Giørtz , Antonsen Sussie , Rommedahl Joen , Agerbo Esben , Mortensen Preben Bo , Sørensen Henrik Toft , Lotz Jonas Færch , Piqueras Laura Cabello , Fierro Constanza , Karamolegkou Antonia , Igel Christian , Rust Phillip , Søgaard Anders , Pedersen Carsten Bøcker 
Published: April 2023

Aim: Linking information on family members in the Danish Civil Registration System (CRS) with information in Danish national registers provides unique possibilities for research on familial aggregation of diseases, health patterns, social factors and demography. However, the CRS is limited in the number of generations that it can identify. To allow more complete familial linkages, we introduce the lite Danish Multi-Generation Register (lite MGR) and the future full Danish MGR that is currently being developed. Methods: We generated the lite MGR by linking the current version of the CRS with historical versions stored by the Danish National Archives in the early 1970s, which contain familial links not saved in the current CRS. We describe and compare the completeness of familial links in the lite MGR and the current version of the CRS. We also describe planned procedures for generating the full MGR by linking the current CRS with scanned archived records from Parish Registers. Results: Among people born in Denmark in 1960 or later, the current CRS contains information on both parents. However, it has limited parental information for people born earlier. Among the 732,232 people born in Denmark during 1950–1959, 444,084 (60.65%) had information on both parents in the CRS. In the lite MGR, it was 560,594 (76.56%). Conclusions: The lite MGR offers more complete information on familial relationships than the current CRS. The lite and full MGR will offer an infrastructure tying together existing research infrastructures, registers and biobanks, raising their joint research value to an unparalleled level.
Stent Implantation and Thromboendarterectomy for the Common Femoral Artery in Real-World Practice
Authors: Iwata Yo , Takahara Mitsuyoshi , Nakama Tatsuya , Fujimura Naoki , Suzuki Kenji , Yamaoka Terutoshi , Fukuzawa Shigeru 
Published: April 2023

Purpose: To compare the outcomes of thromboendarterectomy (TEA) and endovascular therapy (EVT) with stenting for patients with atherosclerotic common femoral artery (CFA) occlusive disease. Materials and Methods: From a retrospective registry of 1193 consecutive patients with CFA treatment performed between 2018 and 2020 at 66 institutions in Japan, we identified patients who underwent TEA (n=432) or stent implantation (n=157). The primary outcome measures were the 1-year primary patency of TEA versus stenting with propensity score matching. The secondary outcome measures were perioperative complications, length of hospital stay, any reintervention, limb salvage, and overall survival. Interaction analysis for primary patency was performed with propensity score stratification to determine the appropriate target population for CFA stenting. Results: Propensity score matching extracted 101 pairs (101 patients in the EVT group and 253 patients in the TEA group). The 1-year primary patency rate was significantly higher in the TEA cohort (92.8% vs 84.6%, p=0.006). The freedom from reintervention rate was also significantly higher in the TEA cohort (94.0% vs 89.9%, p=0.030). However, the 1-year limb salvage (98.7% vs 100.0%, p=0.32), 1-year overall survival (90.8% vs 85.0%, p=0.14), and frequency of perioperative complications were not significantly different between the cohorts (6.9% vs 14.2%, p=0.10). Based on interaction analysis, the superiority of TEA over EVT in terms of patency was less apparent in patients with advanced age and chronic heart failure. Conclusions: Thromboendarterectomy was superior to stenting in terms of primary patency and freedom from revascularization at 1 year. There was no significant difference in the incidence of perioperative complications between both groups. Thromboendarterectomy may be recommended as the standard treatment strategy for patients with atherosclerotic CFA disease, whereas stenting may be considered for patients with advanced age and chronic heart failure. Clinical Impact Thromboendarterectomy compared to stenting was the preferred revascularization strategy for patients with CFA disease in terms of primary patency and freedom from target lesion revascularization during the 1st year. The difference was attenuated in subgroups with advanced age (85 years or older) or chronic heart failure, thus stenting may be considered in patients with these backgrounds.
Effect of papermaking technique parameters on air permeability and sound insulation of glass fiber felt
Authors: Hu Jian , Li Xiaojun , Han Ruonan , Xue Jieyu , Zhang Zhaoying , Peng Jing , Tian Jiayu , Yang Yong 
Published: April 2023

Glass fiber felt (GFF) as a fibrous and porous material has caught much attention because its light mass, low cost and excellent acoustic properties. In this paper, GFF was prepared via the papermaking technique to explore the correlation between glass fiber suspension characteristics and physical properties (uniformity, air permeability and sound insulation) of GFF. The consequence presented that increasing the dispersing times and speeds could decrease aspect ratio and flocculation of fibers, which was useful to improve viscosity and fiber hanging property of glass fiber suspension, and uniformity of GFF. However, there was no visible impact on the air permeability of GFF. The results also indicated that increasing the dispersing times could decrease sound transmission loss (STL), however which could be enhanced by changing the dispersing speeds. The optimal dispersing speed was 3000 r/min and STL could be reached 15.78 dB at 6300 Hz. Generally, GFF could be used as acoustic material for building and transportation.
Predictors of Discharge Destination After Stroke
Authors: Schrage Theresa , Thomalla Götz , Härter Martin , Lebherz Lisa , Appelbohm Hannes , Rimmele David Leander , Kriston Levente 
Published: April 2023

Background Determining the discharge destination after acute stroke care is important to prevent long-term disabilities and improve cost efficiency. Objective The aim of this study was to investigate where stroke patients are discharged to after acute treatment and to identify personal, social, stroke-related, and clinical predictors of discharge destination. Methods The present study included a secondary exploratory analysis of a prospective observational study. Patients with acute ischemic stroke, transient ischemic attack, or intracerebral hemorrhage were recruited consecutively over a 15-month period. A hierarchical multinomial logistic regression was performed to identify predictors of the primary outcome of discharge destination. Results We included 1026 stroke patients (48.7% female) with a mean age of 73.3 years (standard deviation 12.9 years) in the analysis. Overall, 55% of the patients were discharged home, 33% to a rehabilitation center, 3% to a residential facility, and 8% to another acute care hospital. Predictors that statistically significantly influenced the odds of the discharge destination were age, living situation pre-stroke, living location pre-stroke, stroke type, stroke severity, treatment type, and length of stay. Higher stroke severity was associated with discharge to all four inpatient facilities. Conclusions In line with previous research, predictors such as stroke severity and living situation pre-stroke significantly influenced the odds of the discharge destination. In contrast, pre-existing conditions and functional impairment pre-stroke had no significant impact on the primary outcome. This discrepancy could be due to a rather functional study sample before stroke and the use of clinical and patient-reported outcome measures.
Studying Voices of Middle Childhood Online: Conducting Online Video-Based Focus Groups With Children
Authors: Van der Voort Anja , Tessensohn Lisa M. , de Jonge Maretha V. 
Published: April 2023

The use of online focus groups is becoming popular as a qualitative research method and the literature available for evaluating this data collection method is useful. However, to the best of our knowledge almost no methodological information is available on synchronous, online video-based focus groups with children of 10–12 years of age. In this article we describe our experiences with a study in which we conducted a total of 13 online synchronous video-based focus groups with children of this age. Our study generated rich and useful data, however, during our research we also encountered several challenges. In this paper we discuss these challenges concerning a) the technical tools used, b) the interaction between children, and c) ethical issues. We evaluate possible solutions and in doing so, also discuss standard procedures that are used in real-life focus groups, such as the optimum number of children, the duration of the focus groups, and the relation between the moderator and the children. We conclude that, when conducting online focus groups with children, researchers need to consider several aspects beforehand such as using a platform that is well-known to the children, developing a technical step-by-step guide, and recruiting a flexible moderator that is familiar with child development. We propose a flexible framework that includes questions and offers suggestions for conducting online focus groups with children aged 10–12 years. This framework can inform researchers wanting to conduct online focus groups with children in the future.
Long-term outcomes of thoracic endovascular repair with quick fenestrater assisted in situ fenestration for type B aortic dissection
Authors: He Tianxiao , Bai Jun , Wu Jianjin , Liu Yandong , Qu Lefeng 
Published: April 2023

Objectives To report the long-term outcomes of patients with type B aortic dissection (TBAD) treated with thoracic endovascular aortic repair (TEVAR) and quick fenestrated (QF)-assisted in situ fenestration (ISF). Methods Between October 2017 and December 2018, 15 patients with TBAD requiring revascularization of the supra-aortic trunks underwent TEVAR with QF-assisted ISF at our institution. Results Thirteen of the 15 patients were male, and the mean age was 52.87 ± 11.26. The technical success rate was 100%. Thirty-day mortality rate was 0. The median follow-up period was 41 months (range, 35–49). During follow-up, one non-aortic-related death was recorded, no fenestration lost its alignment, and no stroke or stent graft migration was observed. Two patients underwent another successful endovascular repair. One case of type Ib endoleak occurred 19 months postoperatively. This was caused by aortic progression distal to the stent graft. Another stent graft with a larger diameter was implanted in the descending aorta. One case of type Ic endoleak was observed 35 months postoperatively. The patient was diagnosed during the annual follow-up without any symptoms. Another bridging stent graft was implanted into the left subclavian artery distal to the already existing one, and the type Ic endoleak was successfully treated. Conclusions TEVAR with QF-assisted ISF may be an effective treatment for ISF in type B aortic dissection.
Prevalence and factors associated with drug therapy problems among hypertensive patients at hypertension clinic of Mbarara Regional Referral Hospital, Uganda: a |cross-sectional study
Authors: Babirye Merab , Yadesa Tadele Mekuriya , Tamukong Robert , Obwoya Paul Stephen 
Published: April 2023

Background: Despite the use of safe and effective conventional drugs, drug therapy problems (DTPs) pose a threat to the successful management of hypertension. DTPs are of a great concern in health care because of their serious consequences such as poor quality of life, increased health care costs, morbidity and mortality. However, there is no published information regarding the prevalence of DTPs and associated factors among hypertensive patients in Uganda. Objective: The aim of the study was to determine the prevalence and factors associated with DTPs among hypertensive patients at the hypertension clinic of Mbarara Regional Referral Hospital (MRRH). Method: A cross-sectional study was conducted at the hypertension clinic, MRRH, Uganda among 228 hypertensive patients. Data were collected from medical records using a data abstraction tool and patients were interviewed using a structured questionnaire. Data analysis was done using Statistical Package for Social Sciences (SPSS) version 22.0. Descriptive analysis was used to determine the prevalence of DTPs. Logistic regression was used to determine the association between the independent and dependent variables. Variables were considered statistically significant at p-value <0.05. Results: A total of 178 DTPs were identified among 141 hypertensive patients. The prevalence of antihypertensive-related DTPs was 61.8% (95% confidence interval [CI]: 55.3–67.5) with an average of 1.26 ± 0.52 DTPs per patient. Out of 141 participants with DTPs, 109 (77.3%) had one DTP, 27 (19.1%) had 2 DTPs, and 5 (3.5%) had 3 DTPs. The most common types of antihypertensive-related DTPs were ‘dosage too low’ which accounted for 53 (29.8%), followed by ‘adverse drug reactions’ which accounted for 48 (27%). Uncontrolled blood pressure (BP; adjusted odds ratio [AOR]: 4.17; 95% CI: 2.33–7.45, p < 0.001) and routine laboratory test results (AOR: 1.87; 95% CI: 1.04–3.36, p = 0.036) were significantly associated with antihypertensive-related DTPs among hypertensive patients. Conclusion: Almost two-thirds of study participants had antihypertensive-related DTPs. The most common DTPs were ‘dosage too low’ and ‘adverse drug reactions’ which both accounted for almost a third of the total DTPs each. Uncontrolled BP and routine laboratory test results were significantly associated with antihypertensive-related DTPs among the study participants. Our study emphasizes the need for improved patient care by clinical pharmacists to identify and prevent DTPs among hypertensive patients.
Effect of Early Mobilization on Hip and Lower Extremity Postoperative: A Literature Review
Authors: Aprisunadi  , Nursalam Nursalam , Mustikasari Mustikasari , Ifadah Erlin , Hapsari Elsi Dwi 
Published: April 2023

Introduction The incidence of fracture and surgery of the hip and lower extremities is still high. Long postoperative bed rest can potentially increase the incidence of various complications that may increase patients’ morbidity and mortality rate after hip and lower extremities surgery. This literature review aimed to identify the effects of early mobilization on hip and lower extremity postoperative. Methods Search for articles on several databases such as ProQuest, ScienceDirect, CINAHL, Medline, Wiley Online, and Scopus, using the Boolean operator tools with “AND” and “OR” words by combining several keywords according to the literature review topic, with inclusion criteria of those published in the last three years (2019–2021), using a quantitative design, written in English and full-text articles. A total of 435 articles were obtained, screened, and reviewed so that there were 16 (sixteen) eligible articles. Results There were 11 (eleven) effects of early mobilization, that is, shorter the length of stay, lower postoperative complication, lower the pain, increase walking ability, increase quality of life, decrease the rate of readmission, decrease mortality rate, lower the total hospitalization cost, higher number of physical therapy sessions prior to discharge, increase in satisfaction, and no fracture displacement or implant failure. Conclusion This literature review showed that early mobilization is safe and effective in postoperative patients to reduce the risk of complications and adverse events. Nurses and health workers who care for patients can implement early mobilization and motivate patients to cooperate in undergoing early mobilization.