bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fundamental Period Prediction of Infill Reinforced Concrete Structures using an Ensemble of Regressors
Authors: Vijayan Vidya , Joy Chinsu Mereena , Shailesh S 
Published: August 2023

Abstract
The fundamental period places an important role when a structure is designed for seismic load. Infill walls are non-load-bearing walls created mostly from masonry, concrete, and other heavy materials, filled in the primary structural frame for a proper structural cladding system. As a result, this infill wall will increase the stiffness of the structure, thereby fundamental time period is significantly changed. Most of the studies on the fundamental period are not giving much importance to the infill walls even though it is crucial to be analyzed. In this work, we propose an automated and efficient analysis method for predicting the fundamental period of infill Reinforced Concrete frames using machine learning techniques. As the nature of dependency of different independent variables considered in this study is unknown, different regression techniques were chosen for this purpose. So we rely upon an exceptional machine learning technique called ensemble learning, which combines predictions from different models to deduce the final prediction more accurately. The storey numbers, number of spans, length of span, stiffness of infill wall, and percentage of openings are set as input factors, while the value of the fundamental time period is chosen as an output. The proposed regression model's correctness is verified by comparing it to existing formulae in the literature. As a result, in comparison to statistical models, the linear regression model shows an r2 value of 0.98921 and has better ability, flexibility, and accuracy.
Pathogenic SCN2A variants are associated with familial and sporadic hemiplegic migraine
Authors: Riant Florence , Thompson Christopher H. , DeKeyser Jean-Marc , Abramova Tatiana V. , Gazal Steven , Moulin Thierry , Chaigne Denys , Kort Lotfi , Corpechot Michaelle , Tournier-Lasserve Elisabeth , George Alfred L. , Ducros Anne 
Published: August 2023

Abstract

Background: Familial hemiplegic migraine is a severe autosomal dominant subtype of migraine with aura characterized by transient motor weakness during attacks. Previously identified genes CACNA1A, ATP1A2, SCN1A and PRRT2 account for less than 20% of cases with hemiplegic migraine referred for genetic diagnosis.
Objectives and Methods: To identify a novel gene, we conducted a whole-genome linkage analysis combined with mini-exome sequencing in a four-generation pedigree with hemiplegic migraine. A candidate ion channel gene was analyzed for mutations in six other affected pedigrees comprising at least three available affected members, and in a large panel of unrelated probands with hemiplegic migraine referred for molecular diagnosis, all without mutations in the known genes. The functional consequences of the identified variants were determined.
Results: In the discovery pedigree, we identified a heterozygous missense mutation (c.4438A>G, p.Lys1480Glu) in the neuronal voltage-gated sodium channel gene SCN2A, which cosegregated with the hemiplegic migraine phenotype. We detected another mutation (c.769T>A, p.Phe257Ile) cosegregating with hemiplegic migraine in a second family, in which two members also had infantile seizures. A third variant (c.3955C>G, p.Arg1319Gly) was found in a sporadic hemiplegic migraine case. All three SCN2A variants were absent in the genome aggregation database gnomAD. Heterologous expression in HEK293T cells coupled with automated patch clamp recording demonstrated abnormal voltage-dependent and kinetic properties of all three SCN2A variants.
Conclusions:Dysfunction of the neuronal sodium channel SCN2A can be associated with familial and sporadic hemiplegic migraine. Our finding expands the genetic landscape for migraine and contributes to the diverse genotype-phenotype spectrum associated with SCN2A.
Profile Verification and Secured Social Engineering with Machine Learning Models
Authors: GUPTA MANASI , RAJKUMAR SUJATHA , ELANGO KONGUVEL , SUBRAMANIAM SIVA KUMAR 
Published: August 2023

Abstract
Digital media as a platform is one of highest interactive yet sensitive arenas of information technology. With the rise of Online Social Networks, the idea of authentic identity is often seen on the brink of attack with the impact of cases of Social Engineering and other forms of Cyber Threats. The research here mainly aims at developing a Profile Verification Model with existing datasets from platforms such as Instagram. This includes understanding the behavioural aspects of interactions with masked identity elements such as bots and fake accounts Using the concepts of Supervised Machine Learning, its objective is to use existing algorithms such as Random Forest Classifier, K-Nearest Neighbour Classifier, and Linear SVM, using data pre-processing techniques to transform valid input training and testing formats. Finally, drawing comparative results using mathematical operations for accuracy and testing and depict the same through data visualization tools.
Temporal dynamics of the fecal microbiome in female pigs from early life through estrus, parturition, and weaning of the first litter of piglets
Authors: Gaire Tara N. , Scott H. Morgan , Noyes Noelle R. , Ericsson Aaron C. , Tokach Michael D. , William Hayden , Menegat Mariana B. , Vinasco Javier , Nagaraja T. G. , Volkova Victoriya V. 
Published: August 2023

Abstract
Background
Age-associated changes in the gastrointestinal microbiome of young pigs have been robustly described; however, the temporal dynamics of the gut microbiome of the female pig from early life to first parity are not well understood. Our objective was to describe microbiome and antimicrobial resistance (AMR) dynamics of the fecal microbiome of breeding sows from early life through estrus, parturition and weaning of the first litter of piglets (i.e., from 3 to 53 weeks of age).
Results
Our analysis revealed that fecal bacterial populations in developing gilts undergo changes consistent with major maturation milestones. As the pigs progressed towards first estrus, the fecal bacteriome shifted from Rikenellaceae RC9 gut group- and UCG-002-dominated enterotypes to Treponema- and Clostridium sensu stricto 1-dominated enterotypes. After first estrus, the fecal bacteriome stabilized, with minimal changes in enterotype transition and associated microbial diversity from estrus to parturition and subsequent weaning of first litter piglets. Unlike bacterial communities, fecal fungal communities exhibited low diversity with high inter- and intra-pig variability and an increased relative abundance of certain taxa at parturition, including Candida spp. Counts of resistant fecal bacteria also fluctuated over time, and were highest in early life and subsequently abated as the pigs progressed to adulthood.
Conclusions
The bacterial community and antimicrobial resistance of fecal bacteria in female pigs exhibited a stereotypic trajectory primarily driven by the physiological aging process. The fecal bacteriome enterotypes and diversity are found to be age-driven and established by the time of first estrus, with minimal changes observed during subsequent physiological stages, such as parturition and lactation, when compared to the earlier age-related shifts. Future analysis is needed to understand how our results compare to human microbiome dynamics, but the use of pigs as a model for humans is well-established and our findings suggest that the swine fecal microbiome matures in a stereotypic manner, which is a beneficial characteristic for an animal model system.
Factors affecting public transportation in the Covid-19 period
Authors: Kovács Tünde , Huzsvai László , Nagy Adrián , Nábrádi András , Tóth Szabolcs , Bittner Beáta 
Published: August 2023

Abstract
In the European Union Member States, the share of public transport use from the turn of the millennium to the beginning of the pandemic period was 17–18%, while in Hungary, it was 27%. The number of public transport users has fallen due to the Covid-19 virus to 13% in the EU and 21% in Hungary. The decrease can be attributed to changes in travel habits and the impact of the measures taken in the context of the virus situation. In Debrecen, Hungary's second-largest city, the situation is similar. During a shorter period of the first wave of the virus, the public service operator realized only 30% of its usual revenue. The present study analyzes the relationship between the number of active cases of Covid-19, the impact of the measures taken and the number of paying passengers on public transport in Debrecen. Four hypotheses were put forward: 1) travel tickets, 2) general passes, 3) discount passes and 4) supplement passes were influenced by the evolution of Covid-19's active caseload. The data were collected from the Debrecen Transport Company (DKV) for 2020.01–2021.12, and the active Covid-19 case numbers were collected from the Worldometers.info database. Statistical analyses were performed using the ARMA (autoregressive and moving-average) model. We found that all four of our hypotheses had to be rejected, as Covid's active caseload did not influence sales of tickets and various passes.
Distribution characteristics, source analysis and risk assessment of polycyclic aromatic hydrocarbons in sediments of Kuye River: A river in a typical energy and chemical industry zone
Authors: Liu Jinhui , Zhang Aining , Yang Zhuangzhuang , Wei Chunxiao , Yang Lu , Liu Yongjun 
Published: August 2023

Abstract
This study systematically analysed the distribution characteristics, sources and risk assessment of polycyclic aromatic hydrocarbons (PAHs) in Kuye River sediments in an energy and chemical industry base in northern Shaanxi, China. The results revealed the concentrations of 16 PAHs in the sediment ranged from 1090.04 to 32175.68 ng∙g− 1 dw, with the highest proportion of 4-rings PAHs; PMF revealed the main sources of PAHs were the incomplete combustion of fossil fuel, biomass combustion and traffic emissions. The total toxic equivalent concentration of BaP, risk quotient and life time carcinogenic risk of PAHs suggested the moderate to high contamination of PAHs. The higher ILCR indicated the ingestion of PAHs was the main way to impact public health, and children should be more susceptible to PAHs. This study could provide theoretical support for pollution prevention measures and ecological restoration strategies for rivers in energy and chemical areas.
Comorbidities of Prurigo nodularis in Chinese patients: a multicentre retrospective study
Authors: Yin Mengting , Zhong Weilong , Zhou Keren , Dou Xia 
Published: August 2023

Abstract

Prurigo nodularis is a chronic pruritic dermatological disease that is known to be associated with various comorbidities. However, there has been a lack of comorbidity comdition studies specifically focusing on Chinese patients with prurigo nodularis, resulting in a dearth of representative data. To address this gap, we conducted a data collection effort spanning over 16 months, involving collaboration with more than 100 hospitals in China. The collected data was then subjected to statistical analysis, utilizing the Student's t-test to assess differences between two groups, and logistic regression to identify risk factors associated with different comorbidities. The findings of our study revealed that allergic rhinitis, atopic dermatitis, asthma, and food allergy were the most prevalent comorbidities observed in this patient population. Comorbidities exhibit a higher likelihood of impacting males (OR, 1.539; 95% CI, 1.136–2.084), and individuals with comorbidities tend to experience more severe pruritus compared to those without (P = 0.014). Furthermore, this study highlights the intricate interplay among comorbidities.
The relationship between Iranian nurse’s Conflict management Style, their Job Satisfaction and job stress during the Covid-19 Pandemic
Authors: Ganjkhani Ashraf , Esmaeili Maryam , Ashrafizadeh Hadis , Hajibabaee Fatemeh , Haghani Shima 
Published: August 2023

Abstract
Background: one of the influential factors on nurses’ job satisfaction and stress is their conflict management style in the workplace. Conflict management indicates the proper employment of appropriate approaches in a conflict. This study was conducted to determine the relationship between Iranian nurses’ conflict management style, job satisfaction and job stress during the covid-19 pandemics.
Methods: This cross-sectional correlation study was conducted in 2021 in Iran. One hundred eighty nurses who met the inclusion criteria were selected through a stratified random sampling method and were included in the study. In this research, the data collection instruments were demographic data, the Thomas Kilmann conflict management styles questionnaire, the Minnesota Job Satisfaction Scale, and the Osipow job stress assessment, which the nurses completed through self-reporting. The data were analyzed using descriptive and inferential in the SPSS software version 25.
Results: In the assessment of the relationship between job satisfaction and conflict management styles, the only statistically significant relationship was found between conflict management styles and the physical environment (P=0.01), and there was no significant relationship regarding other dimensions of job satisfaction (P>0.05). Moreover, no significant relationships existed between dimensions of conflict management and job stress (P>0.05).
Conclusions: As in the current study, conflict management styles during the covid-19 pandemic did not correlate with environmental and personal factors, and therefore, these two variables can be influenced by factors other than interpersonal interactions such as environmental and personal factors. Therefore, more research in this field can be complementary to our findings. Proper training regarding conflict management style is necessary for nursing managers since they need to identify conflicts and their causes and address them promptly and effectively, particularly in crises and pandemics.
Chromatin accessibility analysis suggested vascular induction of the biliary epithelium via the Notch signaling pathway in the human liver
Authors: Yoshihara Masaharu , Nakayama Takahiro , Takahashi Satoru 
Published: August 2023

Abstract
The biliary epithelial cells (cholangiocytes) in the liver originate from undifferentiated liver parenchymal cells (hepatoblasts) that are located adjacent to the portal vein. This differentiation process is driven by Notch signaling, which is recognized for generating scattered or coalescent patterns, in contrast to one- or two-cell layer (spatially confined) patterning in cholangiocyte differentiation. It is unclear how Notch signaling acts and localizes only in cholangiocytes. A computer simulation study suggested that low production rates of the ligands or receptors of Notch signaling arecrucial for the spatially confined patterning,although biochemical examination is lacking. Here, we analyzed a publicly available single-cell ATAC-sequencing dataset from human fetal liver samples. We showed high chromatin accessibility for the ligands only in vascular cells, while that for the receptor is limited to a small population of hepatoblasts. This finding strengthens the previously proposed idea that low production rates of the ligands or receptors of Notch signaling enable vascular induction of cholangiocytes.
A computational model to design wide field-of-view optic nerve neuroprostheses
Authors: Micera Silvestro , Romeni Simone , De Luca Daniela , Pierantoni Luca , Toni Laura , Marino Gabriele , Moccia Sara 
Published: August 2023

Abstract
Neuroprostheses based on retinal stimulation (RS) allows many individuals affected by retinal degeneration to partially restore visual perception but the produced phosphenes are confined into a narrow region of the visual field. Optic nerve stimulation (ONS) has the potential to produce visual perceptions spanning the whole visual field, but its exploitation is challenging since it produces very elongated phosphenes that cannot be easily organized into meaningful percepts. Here, to address this issue, we introduced a geometrical model that allows us to convert firing rate patterns in the retina and optic nerve into visual perceptions and vice versa. Then, we developed and extensively characterized a method to estimate the best perceptions that can be elicited through a given electrode configuration. This method was used to qualitatively compare ONS and RS also using a set of static and dynamic visual scenes through simulated prosthetic vision (SPV) experiments with healthy subjects. Both simulations and SPV experiments showed that it might be possible to reconstruct natural visual scenes using reasonable amounts of active sites, whose arrangement in the optic nerve section exploits purely geometrical factors. The ability of ONS to cover the whole visual field, allowed perception of much more detail in dynamic scenarios than what is possible with RS, where the narrowing of the visual field results in a limited ability to visualize the scene. Our findings suggest that ONS could represent an interesting approach for vision restoration and that our model can be used to optimize it.
Assessing farmer’s experience and perception to crop feeding long-tailed macaques in West Sumatra, Indonesia: Implication for coexistences and conservation
Authors: Ilham Kurnia , Rizaldi Rizaldi , Tsuji Yamato , Wu Cheng-Yu , Su Yong-Chao 
Published: August 2023

Abstract
Understanding the extent of human-macaque negative interaction due to crop damage is crucial to develop conservation and conflict management strategies. In this study, we investigated conflicts between human and long-tailed macaque (LTM) over crop feeding in Padang, West Sumatra, Indonesia. We conducted an interview survey with a total 200 farmers near protected and unprotected sites to explore the extent of crop feeding affect farmers' and how their attitudes toward conservation of the LTM. Our result showed that most farmers on both sites experienced agronomic damage attributed to crop feeding LTM. Most farmers from both sites reported that crop feeding occurs daily and more frequently in the morning. The financial losses were the main concern of most farmers at both sites. However, we found that the majority of farmers still promote the conservation of the LTM; the farmers considered that the macaques had the right to live. Amongst socio-economic characteristic, regression analysis indicated that coexistences between human and LTM appeared to be related with crop feeding experienced. Conservation supports were largely determined by age and education. The mitigation suggested by the farmers, compensation losses from the government were most desirable. Our findings aid in developing communication strategies for reducing the human-macaque conflicts and improving conservation efforts.
A deep-learning artificial intelligence system for estimating chronological age using panoramic radiography in the Korean population
Authors: Yeom Han-Gyeol , Lee Byung-Do , Lee Wan , Lee Taehan , Yun Jong Pil 
Published: August 2023

Abstract
The purpose of this study was to suggest a hybrid method based on ResNet50 and ViT in an age estimation model using panoramic radiographs for learning by considering both local features and global information, which is important in estimating age. Transverse and longitudinal panoramic images of 9663 patients were selected and used (4774 males and 4889 females with a mean age of 39 years and 3 months). To compare ResNet50, ViT, and the hybrid model, the MAE, mean square error (MSE), root mean square error (RMSE), and coefficient of determination (R2) were used as metrics. The results confirmed that the age estimation model designed using the hybrid method performed better than those using only ResNet50 or ViT. In addition, when examining the basis for age determination in the hybrid model through attention rollout, it was evident that the proposed model used logical and important factors rather than relying on unclear elements as the basis for age determination.
Description of Tropicibacter oceani sp. nov, isolated from the intertidal zone sediment of Chinese Yellow Sea
Authors: Zhou Dan-dan , Xu Xiudan , Zhang Bin-zhe , Feng Ji-xing , Zhang Jian 
Published: August 2023

Abstract
In this study, we reported a Gram-stain-negative, rod-shaped, atrichous, and aerobic bacterial strain named YMD87T, which was isolated from the intertidal zone sediment of Chinese Yellow Sea. Growth of strain YMD87T occurred at 10.0–40.0°C (optimum, 25–30°C), pH 4.0–12.0 (optimum, 8.0) and with 0–6.0% (w/v) NaCl (optimum, 0.0–2.0%). Phylogenetic tree analysis based on 16S rRNA gene sequence indicated that strain YMD87T belonged to the genus Tropicibacter and was closely related to Tropicibacter alexandrii LMIT003T (97.2% sequence similarity). Genomic analysis indicated that strain YMD87T contains a circular chromosome of 3,932,460 bp with G + C content of 63.8% and three circular plasmids of 116,492 bp, 49,209 bp and 49,673 bp, with G + C content of 64.3%. The predominant respiratory quinone of YMD87T was ubiquinone-10 (Q-10). The major polar lipids of YMD87T contained phosphatidylglycerol, phosphatidylethanolamine, five unidentified lipids, five unidentified phospholipids, phosphatidylcholine, unidentified glycolipid and five unidentified aminolipids. The major fatty acids of strain YMD87T contained C12:1 3-OH, C16:0, and summed feature 8 (C18:1 ω7c or/and C18:1 ω6c). Phylogenetic, physiological, biochemical and morphological analyses suggested that strain YMD87T represents a novel species of the genus Tropicibacter, and the name Tropicibacter oceani sp. nov is proposed. The type strain is YMD87T (= MCCC 1K08473T = KCTC 92856T).
Diacerhein Attenuates Sepsis-induced Pulmonary Vascular Endothelial barrier Dysfunction via Inhibition of Advanced Glycation End Products
Authors: Xu Jia , Wei Lingyu , Sun Zaiyuan , Gong Wenqian , Luo Minghao , Peng Junnan , Zhou Xiaomin , Xu Xue , Su Zedazhong 
Published: August 2023

Abstract
AIM
Acute lung injury in sepsis is a life-threatening clinical problem with high mortality and few treatment options, posing a significant challenge for clinicians. Powerful anti-inflammatory anthraquinone derivative dialcerhein (DIA) has numerous targets. The objective of this investigation is to ascertain whether DIA and potential molecular targets can protect mice against sepsis-induced deteriorate of the pulmonary vascular endothelial barrier.
METHODS
Cecal ligation and puncture (CLP) was used to induce sepsis in mice, followed by DIA administration. Survival rate, serum biochemical indicators and advanced glycation end products (AGEs), pulmonary vascular endothelial barrier function, glucose tolerance, and protein expression in lung tissue were all studied using molecular and biochemical approaches.
RESULTS
In septic mice lung tissue, DIA therapy normalized CLP-induced survival rate, vascular hyperpermeability, pulmonary vascular endothelial barrier dysfunction, inflammatory response, insulin tolerance test, AGEs level, and VE-cadherin phosphorylation level. Furthermore, AGEs and Scr interventions could greatly impair the therapeutic efficacy of DIA.
CONCLUSION
In this study, DIA alleviated pulmonary vascular endothelial barrier dysfunction in septic mice by regulating inflammation and lowering insulin resistance through AGEs inhibition. These findings showed that DIA could be a potential therapeutic for sepsis patients.