bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relating weather radar data to migrating waterfowl abundance in the Rainwater Basin of Nebraska
Authors: Liu Boyan , Kemink Kaylan , Sieges Mason , Smolinsky Jaclyn , Varner Dana , Buler Jeffrey 
Published: April 2023

AbstractWaterfowl migrations are large‐scale events that involve millions of birds moving over broad geographic extents, which make them difficult to quantify and study. Historically, wildlife managers have relied mostly on field surveys, such as visual counts from the ground or air that sample at small spatial or temporal extents, or both. Combining field surveys with remote sensing data comprehensively collected over large spatial extents at high temporal frequency may improve the study of migrating waterfowl distributions. We tested the strength of the relationship between broad‐scale weather surveillance radar data and fine‐scale field surveys of waterfowl abundance at wetlands within the Rainwater Basin of Nebraska, USA, from 2017–2019. Radar reflectivity of waterfowl at the peak exodus of evening flights was positively correlated with diurnal waterfowl count data, although there was unexplained variation in the relationship. The association was also very similar across various time scales ranging from daily to monthly averages of waterfowl abundance. We suggest that human‐based ground surveys can calibrate and leverage more comprehensive remote sensing data to get a broad understanding of waterfowl distributions during migration. Several confounding factors, such as spatial displacement between radar and survey observation, individual variation in orientation and body size, and identification of avian species sampled by radar, remain on the path to improving radar‐based waterfowl estimates.
Endoscopic CO2 Laser Resection Using the Inversion Technique in 22 Combined Laryngoceles
Authors: Heuveling Derrek A. , Mahieu Hans F. 
Published: April 2023

ObjectiveTo demonstrate the feasibility of transoral resection of, even large, combined laryngoceles by endoscopic CO2 laser resection using the inversion technique.MethodsA retrospective study over a 25‐year period of 20 patients with 22 combined laryngoceles. All patients were operated on using the CO2 laser inversion technique. Pre‐ and postoperative computed tomography (CT)‐scans or magnetic resonance (MR) imaging were available in all patients.ResultsThere were no surgical problems during all procedures. One patient required a tracheotomy pre‐operatively due to a compromised airway. All procedures were without intraoperative complications. Postoperatively, there were two complications: one hemorrhage, and one patient developed a granuloma with airway compromise. In two patients, residual disease was detected on postoperative imaging. One of them was re‐operated several years later due to the progression of this residual external component of the laryngocele. One patient had a non‐significant small internal laryngocele recurrence. The recurrence rate in this series was 2/22 (9.1%). The majority of patients (15/20) could be discharged from the hospital the day after surgery.ConclusionThe results of this study show excellent control of combined laryngoceles using the CO2 laser inversion technique, with a short hospital stay and a low rate of complications and recurrence. Even in large combined laryngoceles, CO2 laser excision using the inversion technique should be considered.Level of Evidence4 Laryngoscope, 133:2742–2746, 2023
Single‐Ion Gel Polymer Electrolyte based on In‐Situ UV Irradiation Cross‐Linked Polyimide Complexed with PEO for Lithium‐Ion Batteries
Authors: Wang Pinhui , Wang Liying , Liang Xiaoxiao , You Yingxue , Li Zhangnan , Liu Yuhan , Liu Baijun , Sun Zhaoyan , Hu Wei 
Published: April 2023

AbstractLithium‐ion batteries (LIBs) have become the research focus of energy storage products. Due to the combination of Li+ and the Lewis basic sites of polymer chains, anions move more than five times faster, which do not participate in the electrode reaction during the discharge cycles, leading to concentration polarization, voltage losses, and high internal resistance. To solve this phenomenon, in this work, a polymer network structure of single‐ion polymer electrolyte‐based polyimide (DPI‐SIGPE) with plasticizer ethylene carbonate (EC)/dimethyl carbonate (DMC) is formed by in‐situ cross‐linking double bond polyimide, 4‐styrene sulfonyl (benzenesulfonyl) imide, and cross‐linking agent pentaerythritol tetra(2‐thiol acetate) under UV irradiation. By incorporating the anion as a part of the polymer chain, DPI‐SIGPE exhibits high lithium‐ion conductivity of 2.7 × 10−4 S cm−1 at 30 °C and transference number of 0.87. Typical lithium stripping/plating cycling of 900 h demonstrates uniform lithium deposition impacted by DPI‐SIGPE. Meanwhile, it has good dimensional thermal stability with no obvious shrinkage at 200 °C for 0.5 h and wide electrochemical window of 4.6 V. Thus, the polyimide‐based cross‐linked single‐ion gel polymer electrolyte has the promising potential for application in LIBs.
Lymphaticovenous anastomosis for treatment of refractory chylous ascites: A case report
Authors: Tsuzaka Shoichi , Aiyama Takeshi , Kamachi Hirofumi , Kakisaka Tatsuhiko , Orimo Tatsuya , Nagatsu Akihisa , Asahi Yoh , Maeda Taku , Kamiyama Toshiya , Taketomi Akinobu 
Published: April 2023

AbstractChylous ascites, the leakage of lymphatic fluid into the abdominal cavity caused by lymphatic fluid stasis or lymphatic vessel damage, can be treated by lymphaticovenous anastomosis (LVA). We report rarely performed abdominal LVA to treat a case of refractory ascites possibly caused by ligation of the thoracic duct and pleurodesis in a man aged 60 years requiring weekly ascites drainage. Ligation was abandoned because the leakage site was not determined. The greater omentum (GO) was generally edematous and showed lymphatic effusion by gross appearance, and was considered suitable for LVA. We performed once LVA in the lymphatic vessels and veins of the GO using common microsurgical instrumentation and lateral anastomosis. Lymphatic vessels in the omentum were dilated to 2–3 mm, and LVA was simple. After LVA, GO edema improved. Postoperatively, the patient developed paralytic ileus, which improved within a few days, and the patient was discharged without any increase in ascites after starting to diet. One year post‐surgery, there was no recurrence of ascites. LVA at the GO may be effective for the treatment of refractory chylous ascites because of its absorptive lymphatic draining capabilities and large transverse vessels.
Peripheral thyroid hormone deiodination: Entry points to elucidate mechanisms of metabolic adaptation during weight regain
Authors: Dulloo Abdul G. 
Published: April 2023

AbstractThe concept of dual‐adaptive thermogenesis underlying metabolic adaptation to prolonged energy deficit posits that there are two control systems that govern energy sparing: a rapid‐reacting system to energy deficit and a slow‐reacting system to fat store depletion. The latter control system, referred to as the “adipose‐specific” control of thermogenesis, contributes to accelerating fat store replenishment (catch‐up fat) during weight regain. The case is put forward here that, whereas adaptive thermogenesis during weight loss results primarily from central suppression of the sympathetic nervous system and hypothalamic–pituitary–thyroid axis, during weight regain it operates primarily through peripheral tissue resistance to the actions of this neurohormonal network. Emerging evidence that altered deiodination of thyroid hormones within the skeletal muscle and liver is a key determinant of such peripheral resistance therefore offers entry points toward elucidating the molecular mechanisms that underlie the adipose‐specific control of thermogenesis and unraveling tissue‐specific targets to counter obesity recidivism.
Preparation of carbon black/graphene nanosheets/PP composites with 3D separated conductive networks based on selective laser sintering
Authors: Shen Hui , Wu Wei , Hu Huanbo , Rui Zhengguo , Ye Junjian , Zhang Cheng 
Published: April 2023

AbstractThe main research goal of high‐performance conductive polymer composites is to improve electrical conductivity and reduce the percolation threshold. Designing an effective conductive network is one of the fundamental ways to improve the conductivity. In this study, polypropylene composite powders coated with carbon black (CB) and graphene nanosheets (GNSs) were prepared by a combination of ultrasonic dispersion and liquid‐phase deposition, and sintered using a selective laser sintering process to prepare polypropylene composites with three‐dimensional separated conductive networks. The synergistic effect of binary compound fillers of CB and GNSs was utilized to further improve the electrical conductivity of the composites. When the filler loading was 2% and the ratio of CB to graphene was 7:3, the electrical conductivity of the polypropylene composite was 1.315 × 10−3 S/m, which was eight orders of magnitude higher than that of pure polypropylene. In addition, the tensile strength and elongation at break of CB/GNSs/PP composites were improved by 36.4% and 20.77% with excellent mechanical properties. The effects of fillers on the SLS process, thermal stability, melting, and crystallization behavior of the composites were investigated. This study provides an effective and feasible strategy for the preparation of high‐performance conductive polymer composites using SLS 3D printing process.
Moving toward sustainable development: Social, economic and environmental value as antecedents of purchase intention in the sustainable crafts sector
Authors: Prados‐Peña María Belén , Gálvez‐Sánchez Francisco Jesús , García‐López Ana 
Published: April 2023

AbstractSustainable development has become a prevailing strategy for today's society, increasingly aware of the new challenges we face. This is causing consumers to demand and adopt more sustainable purchasing behaviors, based on the perception of different values. This article examines the relationship between social value, economic value, and environmental value with perceived quality and perceived value as antecedents of purchase intent in the sustainable crafts sector. The data were collected through an online survey. The model has been analyzed using a SEM model with Smart‐PLS. The results show that economic and environmental values positively influence attitude and perceived quality. However, social value only positively influences attitude. Both attitude and perceived quality have a positive effect on the purchase intention of sustainable artisanal products. In the final section, we discuss in detail the theoretical and practitioner implications of the findings obtained.
Neubau der Büchler Brücke in Luxemburg
Authors: Gesella Heiko , Eicher Charel , Duvoisin Eric 
Published: April 2023

AbstractDas Verkehrsinfrastrukturprojekt Neue Nationalstraße N3 übergreift mehrere Stadtteile der Landeshauptstadt Luxemburg und beinhaltet den in diesem Zuge notwendig gewordenen Ersatzneubau der Büchler Brücke, welche alle zwölf südlich des Hauptbahnhofs abgehenden Eisenbahngleise unterführt. Der neue Brückenentwurf wird von einem deutlich verbreiterten Verkehrsquerschnitt geprägt, der neben breiteren Geh‐ und Radwegen insgesamt sechs Spuren für Straßenverkehr und eine neue zweigleisige Straßenbahntrasse führt. Der Verkehr wird von einem ungeteilten Trägerrost getragen, dessen drei Hauptträger in Form von Stahlsegeln über den schiefen Zwischenstützen die Fahrbahnplatte durchstoßen. Der Entwurf der neuen Brücke wird von der kleinen möglichen Bauhöhe unterhalb der Fahrbahnebene geprägt, welche sich aus dem unverändertem Längsprofil der N3 im Bauwerksbereich und der um 0,85 m vergrößerten lichten Höhe für Eisenbahnverkehr unter der Brücke ergab. Vorliegend wird von der diesbezüglichen Planung und der anspruchsvollen Bauausführung an gleicher Stelle unter vollem Verkehr berichtet.
Multi‐objective optimization and assessment of recycled concrete aggregates for sustainable development: Example of the Kömürhan bridge
Authors: Ulucan Muhammed , Tas Yavuzhan , Alyamac Kursat Esat 
Published: April 2023

AbstractThe main purpose of this study is to examine the advantages and disadvantages of the Kömürhan bridge, built with natural aggregate concrete in Elazig, in terms of mechanical, environmental, and economic properties if certain ratios of recycled concrete aggregate (RCA) were used. For this purpose, a detailed laboratory study was designed, and concrete samples were produced, all‐natural, all‐recycled, and both recycled and containing natural aggregates. Different water‐to‐cement, aggregate‐to‐cement, and recycled concrete aggregate‐to‐total aggregate ratios were considered for the mixture designs of these samples, and the fresh and hardened concrete properties of these samples were determined. Then, statistical analyses were made using the response surface method, and numerical models were developed to predict the fresh and hardened concrete properties with high accuracy. Mixtures containing RCA, which have the same fresh and hardened concrete properties as the fresh and hardened concrete properties of the Kömürhan bridge, which was selected as an example structure by using these models, were determined for optimization purposes. A detailed environmental and economic comparison of the optimization and reference mixtures was made. While making environmental assessments, energy consumption, global warming potential, waste generation, and abiotic depletion were considered. It was seen that the optimization mixtures were more economical and more environmentally friendly than the reference mixture. As a result of this study, it was predicted that the use of RCA in buildings constructed using large amounts of concrete could provide significant environmental and economic advantages and was exemplified by the Kömürhan bridge.
Equivalence between C5F10O Addition and PTFE Vapor Contamination in the Particle Composition and Critical Electric Field Strength of High‐Temperature CO2/O2 Gas Mixture
Authors: Tsusaka Akihiro , Kurahashi Jun , Yokoi Toshiya , Matsumura Toshiro , Nanahara Toshiya , Yukita Kazuto , Goto Yasuyuki , Yokomizu Yasunobu 
Published: April 2023

AbstractSF6 has been introduced as an insulating and extinguishing gas in gas circuit breakers. However, its global warming potential is significantly high at approximately 25 200. Therefore, development of alternative gases is essential. We have been investigating the dielectric breakdown characteristics of high temperature CO2 gas contaminated by various gases. This study discusses the equivalent condition between high temperature CO2/O2/C5F10O gas mixture and CO2/O2 gas mixture contaminated with PTFE (C2F4) vapor because both gas mixtures consist of C, O, and F atoms. It is concluded that when the mole fractions of every atom are equivalent between both gas mixtures, both gas mixtures have the same characteristics as each other, such as the particle composition and critical electric field strength. © 2023 Institute of Electrical Engineers of Japan. Published by Wiley Periodicals LLC.
On holographic time-like entanglement entropy
Authors: Li Ze , Xiao Zi-Qing , Yang Run-Qiu 
Published: April 2023

Abstract
In order to study the pseudo entropy of timelike subregions holographically, the previous smooth space-like extremal surface was recently generalized to mix space-like and time-like segments and the area becomes complex value. This paper finds that, if one tries to use such kind of piecewise smooth extremal surfaces to compute timelike entanglement entropy holographically, the complex area is not unique in general. We then generalize the original holographic proposal of spacelike entanglement entropy to pick up a unique area from all allowed “space-like+time-like” piecewise smooth extremal surfaces for a timelike subregion. We give some concrete examples to show the correctness of our proposal.
Measuring the susceptibility to visually induced motion sickness and its relationship with vertigo, dizziness, migraine, syncope and personality traits
Authors: Lukacova Ivana , Keshavarz Behrang , Golding John F. 
Published: April 2023

AbstractThe widespread use of visual technologies such as Virtual Reality increases the risk of visually induced motion sickness (VIMS). Previously, the 6-item short version of the Visually Induced Motion Sickness Susceptibility Questionnaire (VIMSSQ short form) has been validated for predicting individual variation in VIMS. The aim of the current study was to investigate how the susceptibility to VIMS is correlated with other relevant factors in the general population. A total of 440 participants (201 M, 239F), mean age 33.6 (SD 14.8) years, completed an anonymous online survey of various questionnaires including the VIMSSQ, Motion Sickness Susceptibility Questionnaire (MSSQ), Vertigo in City questionnaire (VIC), Migraine (scale), Social & Work Impact of Dizziness (SWID), Syncope (faintness), and Personality (‘Big Five’ TIPI). The VIMSSQ correlated positively with the MSSQ (r = 0.50), VIC (r = 0.45), Migraine (r = 0.44), SWID (r = 0.28), and Syncope (r = 0.15). The most efficient Multiple Linear Regression model for the VIMSSQ included the predictors MSSQ, Migraine, VIC, and Age and explained 40% of the variance. Factor analysis of strongest correlates with VIMSSQ revealed a single factor loading with VIMSSQ, MSSQ, VIC, Migraine, SWID, and Syncope, suggesting a common latent variable of sensitivity. The set of predictors for the VIMSSQ in the general population has similarity with those often observed in patients with vestibular disorders. Based on these correlational results, we suggest the existence of continuum of underlying risk factors for sensitivity, from healthy population to patients with extreme visual vertigo and perhaps Persistent Postural-Perceptual Dizziness.
First-in-human study of oleclumab, a potent, selective anti-CD73 monoclonal antibody, alone or in combination with durvalumab in patients with advanced solid tumors
Authors: Bendell Johanna , LoRusso Patricia , Overman Michael , Noonan Anne M. , Kim Dong-Wan , Strickler John H. , Kim Sang-We , Clarke Stephen , George Thomas J. , Grimison Peter S. , Barve Minal , Amin Manik , Desai Jayesh , Wise-Draper Trisha , Eck Steven , Jiang Yu , Khan Anis A. , Wu Yuling , Martin Philip , Cooper Zachary A. , Elgeioushi Nairouz , Mueller Nancy , Kumar Rakesh , Patel Sandip Pravin 
Published: April 2023

Abstract
Background
CD73 upregulation in tumors leads to local immunosuppression. This phase I, first-in-human study evaluated oleclumab (MEDI9447), an anti-CD73 human IgG1λ monoclonal antibody, alone or with durvalumab in patients with advanced colorectal cancer (CRC), pancreatic ductal adenocarcinoma (PDAC), or epidermal growth factor receptor-mutant non-small-cell lung cancer (NSCLC).

Methods
Patients received oleclumab 5–40 mg/kg (dose-escalation) or 40 mg/kg (dose-expansion) intravenously every 2 weeks (Q2W), alone (escalation only) or with durvalumab 10 mg/kg intravenously Q2W.

Results
192 patients were enrolled, 66 during escalation and 126 (42 CRC, 42 PDAC, 42 NSCLC) during expansion. No dose-limiting toxicities occurred during escalation. In the monotherapy and combination therapy escalation cohorts, treatment-related adverse events (TRAEs) occurred in 55 and 54%, respectively, the most common being fatigue (17 and 25%). In the CRC, PDAC, and NSCLC expansion cohorts, 60, 57, and 45% of patients had TRAEs, respectively; the most common were fatigue (15%), diarrhea (9%), and rash (7%). Free soluble CD73 and CD73 expression on peripheral T cells and tumor cells showed sustained decreases, accompanied by reduced CD73 enzymatic activity in tumor cells. Objective response rate during escalation was 0%. Response rates in the CRC, PDAC, and NSCLC expansion cohorts were 2.4% (1 complete response [CR]), 4.8% (1 CR, 1 partial response [PR]), and 9.5% (4 PRs), respectively; 6-month progression-free survival rates were 5.4, 13.2, and 16.0%.

Conclusions
Oleclumab ± durvalumab had a manageable safety profile, with pharmacodynamic activity reflecting oleclumab’s mechanism of action. Evidence of antitumor activity was observed in tumor types that are generally immunotherapy resistant.

Clinical trial registration
Clinicaltrials.gov, NCT02503774; date of registration, July 17, 2015.
Factors impacting the efficacy of the in-situ vaccine with CpG and OX40 agonist
Authors: Pieper Alexander A. , Spiegelman Dan V. , Felder Mildred A. R. , Feils Arika S. , Tsarovsky Noah W. , Zaborek Jen , Morris Zachary S. , Erbe Amy K. , Rakhmilevich Alexander L. , Sondel Paul M. 
Published: April 2023

Abstract
Background
The in-situ vaccine using CpG oligodeoxynucleotide combined with OX40 agonist antibody (CpG + OX40) has been shown to be an effective therapy activating an anti-tumor T cell response in certain settings. The roles of tumor volume, tumor model, and the addition of checkpoint blockade in the efficacy of CpG + OX40 in-situ vaccination remains unknown.

Methods
Mice bearing flank tumors (B78 melanoma or A20 lymphoma) were treated with combinations of CpG, OX40, and anti-CTLA-4. Tumor growth and survival were monitored. In vivo T cell depletion, tumor cell phenotype, and tumor infiltrating lymphocyte (TIL) studies were performed. Tumor cell sensitivity to CpG and macrophages were evaluated in vitro.

Results
As tumor volumes increased in the B78 (one-tumor) and A20 (one-tumor or two-tumor) models, the anti-tumor efficacy of the in-situ vaccine decreased. In vitro, CpG had a direct effect on A20 proliferation and phenotype and an indirect effect on B78 proliferation via macrophage activation. As A20 tumors progressed in vivo, tumor cell phenotype changed, and T cells became more involved in the local CpG + OX40 mediated anti-tumor response. In mice with larger tumors that were poorly responsive to CpG + OX40, the addition of anti-CTLA-4 enhanced the anti-tumor efficacy in the A20 but not B78 models.

Conclusions
Increased tumor volume negatively impacts the anti-tumor capability of CpG + OX40 in-situ vaccine. The addition of checkpoint blockade augmented the efficacy of CpG + OX40 in the A20 but not B78 model. These results highlight the importance of considering multiple preclinical model conditions when assessing the efficacy of cancer immunotherapy regimens and their translation to clinical testing.