bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of a model to investigate the effect of the bias in SNIa measurements related to the inhomogeneity of space
Authors: Deledicque Vincent 
Published: July 2023

AbstractIt has been suggested recently that the apparent accelerated expansion of the universe could be explained by a bias in the SNIa measurements. Such events indeed occur mainly in overdense regions, where matter is located, and whose dynamics can perhaps not been considered as representative of the one of the universe. In this article, we develop a model to investigate in more detail the effect of this bias. This model depends on one single parameter, related to the void fraction of space, and leads to simple analytical relations. We determine in particular the average metric tensor in overdense regions, and deduce that the scale factor and the rate at which proper time progresses in such regions differ significantly from the corresponding values expected on the average space. We then quantitatively deduce how redshift and luminosity distance measurements are affected by the bias, taking into account the perturbation of the metric tensor. Using a value for the void fraction corresponding to the order of magnitude found in the literature, we show that the model is able to predict a distance modulus versus redshift relation being in excellent agreement with the one corresponding to a universe characterized by $$\Omega _{m,0} = 0.3$$

Ω

m
,
0

=
0.3

and $$\Omega _{\Lambda ,0} = 0.7$$

Ω

Λ
,
0

=
0.7

.
PACMNET V1, N1, June 2023 Editorial
Authors: Mellia Marco , Steenkiste Peter , Qiu Lili , Bonaventure Olivier 
Published: July 2023

We are very excited to introduce the first issue of the ACM Proceedings of the ACM on Networking (PACMNET) journal. The Proceedings of the ACM series presents the highest-quality research conducted in diverse areas of computer science, as represented by the ACM Special Interest Groups (SIGs). PACMNET focuses on contributions presenting significant and novel research results on emerging computer networks and their applications.
PACMNET was created to collect top-quality scholarly articles in the area of computer networking. PACMNET encourages submissions that present new technologies, novel experimentation, creative use of networking technologies, and new insights made possible using analysis. The journal is strongly supported by the ACM Special Interest Group on Communications and Computer Networks (SIGCOMM) and involves top-level researchers in its Editorial Board.bWe started working on PACMNET in 2019, with the idea of having a new journal that guarantees both a fast publication time and a very rigorous and constructive review process. The creation of PACMNET was done with the enthusiastic support of the ACM SIGCOMM community, and it will be especially attractive for networking researchers from regions where conference publications are no valued.
Top-down threat bias in pain perception is predicted by higher segregation between resting-state networks
Authors: Pak Veronika , Hashmi Javeria Ali 
Published: July 2023

Abstract
Top-down processes such as expectations have a strong influence on pain perception. Predicted threat of impending pain can affect perceived pain even more than the actual intensity of a noxious event. This type of threat bias in pain perception is associated with fear of pain and low pain tolerance, and hence the extent of bias varies between individuals. Large-scale patterns of functional brain connectivity are important for integrating expectations with sensory data. Greater integration is necessary for sensory integration; therefore, here we investigate the association between system segregation and top-down threat bias in healthy individuals. We show that top-down threat bias is predicted by less functional connectivity between resting-state networks. This effect was significant at a wide range of network thresholds and specifically in predefined parcellations of resting-state networks. Greater system segregation in brain networks also predicted higher anxiety and pain catastrophizing. These findings highlight the role of integration in brain networks in mediating threat bias in pain perception.
Jingle Bells: How Do Bells Affect the Wellbeing, Safety, and Identity of Guide Dog Teams?
Authors: Warda Tiamat 
Published: July 2023

Abstract
Some visually impaired individuals will attach a small bell to their guide dog’s collar to locate them acoustically, yet existing literature on this topic is lacking. This paper analyzes how bells can affect the wellbeing, welfare, and safety of guide dog teams. The ways in which bells alter personal, social, and collective identities are also explored. Results are based on autoethnographic data from the researcher’s six years as a professional guide dog mobility instructor and 12 anonymous online survey responses from participants who have lived with a guide dog. This paper concludes that although bells can offer benefits, they are not a solution for all guide dog teams. Alternatives such as collar tags, GPS devices, walking with sighted volunteers, or training guide dogs to nudge their human partner’s hand when called are addressed.
Collective Voice and Organizing in Digital Labour Platforms in Portugal
Authors: Boavida Nuno , Roque Isabel , Moniz António Brandão 
Published: July 2023

Abstract
The use of digital platforms for managing work grew considerably in Portugal, especially in the aftermath of the Great Recession. This new form of digital and platform work intensified the use of an on-demand workforce, not involved in the bargaining process, subject to indecent working conditions, social control and surveillance and the possibility of accessing social benefits, creating new obstacles for organising. Between 2019 and 2021, semi-structured interviews with workers, activists involved in associations and social movements, trade unionists and key informers were conducted. Also desk research involved five case-studies in Portugal, as part of a European research project. Results allowed to establish a typification of digital platform workers and to analyse collective action and voice in the country.
Comparison of perineal urethrostomy versus augmentation urethroplasty in anterior urethral stricture disease
Authors: Sharma Govind , Desai Sandip , Priyadarshi Shivam , Negi Saurabh 
Published: July 2023

Purpose: Perineal urethrostomy and urethroplasty are very good options for complex and long anterior urethral strictures. A perineal urethroplasty is usually a neglected option. To our knowledge, a comparative study between augmentation urethroplasty and perineal urethrostomy has been not conducted regarding subjective and patient reported outcome measures. We compared both these groups in a high volume tertiary care hospital. Materials and methods: A prospective comparative study of augmentation urethroplasty and perineal urethroplasty for long anterior urethral stricture. it was defined by strictures of more than 3 cm. We compared demographic data, urinary and sexual function; and quality of life using validated PROMs (patient-reported outcome measures) between both above groups. Results: Both groups had 40 patients each. IPSS score improvement for PU and AUP were 20 and 19.6, respectively( p = 0.1223); IIEF-5 score improvement for PU and AUP at baseline and after 6 months were 14.3 and 16.7, respectively( p = 0.1433); QOL score improvement for PU and AUP were 3.45 and 3.05, respectively; which was statistically significant ( p ⩽ 0.001). Conclusions: Perineal urethrostomy is a good but neglected option for complex and long anterior urethral strictures and it should be considered one of the reliable treatment option for patients with long-segment urethral strictures.
A concept analysis of misconduct: Application to nursing education
Authors: Al Abrawi Said 
Published: July 2023

Background Behavior is known as misconduct when individuals do not adhere to ethical standards, rules, or regulations. Several factors lead to misconduct, including the lack of understanding of what misconduct is among undergraduate students. However, misconduct as a concept needs more clarity and specificity. Objective This study aimed to examine the concept of misconduct from the literature and establish an operational definition for application to nursing education. Research design A concept analysis using Rodger’s evolutionary view was used to analyze the literature from the disciplines of: academics, business, law, and religious perspectives. Findings and discussion An operational definition was developed based on the multidisciplinary concept analysis. A concept map was designed to help visualize the antecedents, attributes, and consequences and to assist in the conceptualization of misconduct. Implications for nursing science, administration, and education are provided. Conclusion Understanding misconduct is necessary for nurse educators to ensure ethical practice within the academic context.
Evaluation of the Potential Diagnostic Role of the Lnc-MIAT, miR-29a-3p, and FOXO3a ceRNA Networks as Noninvasive Circulatory Bioindicator in Ductal Carcinoma Breast Cancer
Authors: Razi Shokufeh , Mozdarani Hossein , Behzadi Andouhjerdi Roudabeh 
Published: July 2023

Background: Over the last few decades, tremendous progress has been achieved in the early detection and treatment of breast cancer (BC). However, the prognosis remains unsatisfactory, and the underlying processes of carcinogenesis are still unclear. The purpose of this research was to find out the relationship between myocardial infarction–associated transcript ( MIAT), FOXO3a, and miRNA29a-3p and evaluated the expression levels in patients compare with control and their potential as a noninvasive bioindicator in whole blood in BC. Methods: Whole blood and BC tissue are taken from patients before radiotherapy and chemotherapy. Total RNA was extracted from BC tissue and whole blood to synthesize complementary DNA (cDNA). The expression of MIAT, FOXO3a, and miRNA29a- 3p was analyzed by the quantitative reverse transcription-polymerase chain reaction (RT-qPCR) method and the sensitivity and specificity of them were determined by the receiver operating characteristic (ROC) curve. Bioinformatics analysis was used to understand the connections between MIAT, FOXO3a, and miRNA29a- 3p in human BC to develop a ceRNA (competitive endogenous RNA) network. Results: We identified that in ductal carcinoma BC tissue and whole blood, MIAT and FOXO3a were more highly expressed, whereas miRNA29a- 3p was lower compared with those in nontumor samples. There was a positive correlation between the expression levels of MIAT, FOXO3a, and miRNA29a- 3p in BC tissues and whole blood. Our results also proposed miRNA29a- 3p as a common target between MIAT and FOXO3a, and we showed them as a ceRNA network. Conclusions: This is the first study that indicates MIAT, FOXO3a, and miRNA29a- 3p as a ceRNA network, and their expression was analyzed in both BC tissue and whole blood. As a preliminary assessment, our findings indicate that combined levels of MIAT, FOXO3a, and miR29a- 3p may be considered as potential diagnostic bioindicator for BC.
Preparation and electromagnetic performance of a light-weight, thin, and high-gain three-dimensional woven hollow structure microstrip antenna
Authors: Lyu Lihua , Wang Rongrui , Zhang Duoduo , Zhou Xinghai , Gao Yuan 
Published: July 2023

With the popularity of 5 G, there is an increasing request for a light, high-performance, and stable structure for wireless communication. To solve the problems of delamination cracking and its own heavy weight of the conventional microstrip antenna, this study used ultra-high molecular weight polyethylene (UHMWPE) filament tows and purple copper filament tows as raw materials to prepare 3D woven hollow structure microstrip antenna preforms on a common loom. Using the prepared preforms for reinforcement and resin as the matrix, the VARTM process was used to prepare a 3D woven hollow structure microstrip antenna with a height of 6.8 mm, a weight of 35 g, and a bulk density of 0.7 g/cm3. The combination of the electromagnetic performance test and HFSS software simulation shows that the antenna has excellent radiation performance with a gain of 7.5 dB and a measured VSWR of 1.25. The mechanical performance test results show that it can withstand a maximum compression load of 2982 N and a maximum bending load of 364 N with no obvious delamination at the fracture. It is light, thin, and load-bearing with excellent radiation performance. There will be great potential in the unmanned field and the space field in the future.
Exercise Intolerance That Resolved After venous Stenting of the Inferior Vena Cava
Authors: Bakas Jay M. , Moelker Adriaan , Malskat Wendy S. J. , Van Rijn Marie Josee E. 
Published: July 2023

Venous stenting could alleviate exercise intolerance associated with chronic inferior vena cava (IVC) obstruction. We describe a 36-year-old male patient with an unknown IVC-obstruction. The obstruction was discovered after a bi-iliac deep vein thrombosis (DVT). The thrombus was resolved using thrombolysis. In the chronic phase, the patient developed exercise intolerance without any leg-specific symptoms or signs. Venous stenting was performed to open the IVC-obstruction, 1 year after the acute DVT. His physical condition improved, but cardiac magnetic resonance imaging at rest did not reveal hemodynamical changes after stenting. The Short Form Health Survey (SF-36) physical and mental component summaries were increased from 40.3 to 46.1 and 42.2 to 53.7, respectively. In patients with iliocaval obstruction, improved venous flow without changes in resting hemodynamics can enhance exercise intolerance and quality of life, even in the absence of leg symptoms. Diagnostic tools performed only at rest may miss abnormalities.
Impact of the introduction of medical cannabis in the UK on risk perception and recreational use of cannabis: A longitudinal and cross-sectional analysis
Authors: Waldron Jon , Grabski Meryem , Freeman Tom P , van Laar Margriet , Curran H Valerie 
Published: July 2023

Background Cannabis was rescheduled in the UK in November 2018 so that it can now be prescribed as a treatment for certain medical conditions. It is not yet known whether this has had an impact on peoples’ perception of its risk or on their recreational use of cannabis. Methods This study used data from longitudinal and cross-sectional components of an online survey investigating drug use and nightlife behaviours, comparing data before and after rescheduling of cannabis in November 2018. Participants’ awareness of the change in policy and its impact on cannabis use were assessed for participants in both the cross-sectional and longitudinal arms. The perception of the risk of recreational cannabis use, past 12-month use and use frequency were assessed pre- and post-policy change among the longitudinal sample. Results 414 longitudinal (57.3% response rate) and 2001 cross-sectional participants completed the online survey, resulting in a total sample size of 2415. Just over half the sample (53.5%) were aware of the change in policy to allow for the medical provision of cannabis, with almost 90% saying this would have no impact on their recreational and approximately 80% no impact on their medical use of cannabis, irrespective of prior awareness. No significant differences were found with respect to risk perception, past 12-month cannabis use, or use frequency pre- and post-policy change among the longitudinal sample. Conclusions The change in UK policy to allow for the medical provision of cannabis for some conditions had a limited impact on intentions to use cannabis, and was not associated with longitudinal changes in risk perception or temporal use patterns.
Comparison of the effect of vaginal vitamin E cream with conjugated estrogen vaginal cream on vulvovaginal atrophy and overactive bladder syndrome: a randomized controlled trial
Authors: Azari Nazila , Mehrabi Esmat , Javadzadeh Yousef , Hakimi Sevil 
Published: July 2023

Abstract
Objectives
The present study aimed to investigate the effect of vitamin E on vulvovaginal atrophy (VVA) and overactive bladder syndrome (OABS).

Materials and methods
This trial was conducted on 72 postmenopausal women referring to health centers. Participants were randomly divided into the intervention (vitamin E, vaginal cream) and control (conjugated estrogen, vaginal cream) groups. The duration of the intervention was eight weeks, as they took medicine every day in the first week and then, twice a week. The primary outcome is to compare the symptoms of VVA in the intervention and control groups, and the secondary outcome includes the comparison of the mean score of OABS, pH, vaginal health index (VHI), and side effects eight weeks after treatment.

Results
The mean score of VVA in both groups improved significantly during eight-week, and the difference between the groups was not statistically significant [Adjusted mean difference (AMD): 0.63, 95% Confidence interval (CI) − 1.03–2.28, p = 0.449]. The mean score of OABS decreased significantly in both groups, and the difference between the groups was not statistically significant [AMD: 0.261, 95% CI − 1.278–1.799, p = 0.736]. The mean score of VHI increased significantly in both groups, and the difference between the groups was not significant [AMD: 0.64, 95% CI − 0.13–1.42, p = 0.101].

Conclusion
Vaginal vitamin E cream may be an alternative to vaginal estrogen in the symptom relief of vaginal atrophy and OABS among postmenopausal women, especially those who cannot use hormone therapy.
Antibiotic resistance, biofilm formation, and virulence genes of Streptococcus agalactiae serotypes of Indian origin
Authors: Verma Shalini , Kumari Monika , Pathak Anurag , Yadav Vikas , Johri Atul Kumar , Yadav Puja 
Published: July 2023

Abstract
Background
Group B Streptococcus (GBS) is a causative agent of various infections in newborns, immunocompromised (especially diabetic) non-pregnant adults, and pregnant women. Antibiotic resistance profiling can provide insights into the use of antibiotic prophylaxis against potential GBS infections. Virulence factors are responsible for host–bacteria interactions, pathogenesis, and biofilm development strategies. The aim of this study was to determine the biofilm formation capacity, presence of virulence genes, and antibiotic susceptibility patterns of clinical GBS isolates.

Results
The resistance rate was highest for penicillin (27%; n = 8 strains) among all the tested antibiotics, which indicates the emergence of penicillin resistance among GBS strains. The susceptibility rate was highest for ofloxacin (93%; n = 28), followed by azithromycin (90%; n = 27). Most GBS strains (70%; n = 21) were strong biofilm producers and the rest (30%; n = 9) were moderate biofilm producers. The most common virulence genes were cylE (97%), pavA (97%), cfb (93%), and lmb (90%). There was a negative association between having a strong biofilm formation phenotype and penicillin susceptibility, according to Spearman’s rank correlation analysis.

Conclusion
About a third of GBS strains exhibited penicillin resistance and there was a negative association between having a strong biofilm formation phenotype and penicillin susceptibility. Further, both the strong and moderate biofilm producers carried most of the virulence genes tested for, and the strong biofilm formation phenotype was not associated with the presence of any virulence genes.
Effects of editing DFR genes on flowers, leaves, and roots of tobacco
Authors: Jiang Jiarui , Huang Haitao , Gao Qian , Li Yong , Xiang Haiying , Zeng Wanli , Xu Li , Liu Xin , Li Jing , Mi Qili , Deng Lele , Yang Wenwu , Zhang Jianduo , Yang Guangyu , Li Xuemei 
Published: July 2023

Abstract
Background
DFR is a crucial structural gene in plant flavonoid and polyphenol metabolism, and DFR knockout (DFR-KO) plants may have increased biomass accumulation. It is uncertain whether DFR-KO has comparable effects in tobacco and what the molecular mechanism is. We employed the CRISPR/Cas9 method to generate a knockout homozygous construct and collected samples from various developmental phases for transcriptome and metabolome detection and analysis.

Results
DFR-KO turned tobacco blossoms white on homozygous tobacco (Nicotiana tabacum) plants with both NtDFR1 and NtDFR2 knockout. RNA-seq investigation of anthesis leaf (LF), anthesis flower (FF), mature leaf (LM), and mature root (RM) variations in wild-type (CK) and DFR-KO lines revealed 2898, 276, 311, and 101 differentially expressed genes (DEGs), respectively. DFR-KO primarily affected leaves during anthesis. According to KEGG and GSEA studies, DFR-KO lines upregulated photosynthetic pathway carbon fixation and downregulated photosystem I and II genes. DFR-KO may diminish tobacco anthesis leaf photosynthetic light reaction but boost dark reaction carbon fixation. DFR-KO lowered the expression of pathway-related genes in LF, such as oxidative phosphorylation and proteasome, while boosting those in the plant–pathogen interaction and MAPK signaling pathways, indicating that it may increase biological stress resistance. DFR-KO greatly boosted the expression of other structural genes involved in phenylpropanoid production in FF, which may account for metabolite accumulation. The metabolome showed that LF overexpressed 8 flavonoid metabolites and FF downregulated 24 flavone metabolites. In DFR-KO LF, proteasome-related genes downregulated 16 amino acid metabolites and reduced free amino acids. Furthermore, the DEG analysis on LM revealed that the impact of DFR-KO on tobacco growth may progressively diminish with time.

Conclusion
The broad impact of DFR-KO on different phases and organs of tobacco development was thoroughly and methodically investigated in this research. DFR-KO decreased catabolism and photosynthetic light reactions in leaves during the flowering stage while increasing carbon fixation and disease resistance pathways. However, the impact of DFR-KO on tobacco growth steadily declined as it grew and matured, and transcriptional and metabolic modifications were consistent. This work offers a fresh insight and theoretical foundation for tobacco breeding and the development of gene-edited strains.