bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exclusive Breastfeeding Promotion Utilizing Targeted Client Communication via Text Messaging in Roatán, Honduras
Authors: Rasmussen Lisa N. , Yeung Andrew A. , Herlihy Julie M. , Donnelly John J. , Fine Jeffrey R. , Yuk Jihey , Fernández Sarah H. , Cerritos Karla , Chantry Caroline J. 
Published: January 2023

Abstract
Background: Exclusive breastfeeding (EBF) for 6 months provides significant benefits, including decreased incidence of respiratory and GI infections. Promoting EBF is a cost-effective method to improve infant health and survival. Roatán is a Honduran island where infant mortality is more than triple the country’s average. Data on infant feeding practices and EBF prevalence in Roatan is limited.
Objective: To determine if breastfeeding support and education through TCCMD will increase the prevalence of exclusive breastfeeding for 2-month-old infants in Roatán, Honduras.
Methods: From 08/16-05/17, a cross-sectional baseline survey assessed infant feeding practices and EBF prevalence at 2, 4, and 6 months of age. From 9/17-11/19, we recruited mothers of term infants with intention to breastfeed, access to a mobile device from Roatan Public Hospital’s postpartum ward to receive 158 text messages promoting EBF over 6 months. Surveys assessing EBF were collected at 2, 4, and 6 months of age (+/- 14 days). EBF was defined as given only breastmilk in the last 24 hours.
Results: 581 mothers were enrolled in the intervention group, 227, 171, and 89 surveys were completed at 2, 4, and 6 months of age, respectively. EBF prevalence for the intervention group at 2 months was 37.9% compared to 13.6% in the historical control group (p<0.0001). At 4 and 6 months, 28.7% and 13.5% of the intervention group reported EBF vs. 16.7% and 8.7% of the historical control group, p<0.05 and 0.73 respectively. Odds of EBF at 2 months, adjusted for mother’s age, education, occupation, and SES indicators, were 4.2 times higher in the intervention group compared to baseline group (p<0.0001, 95% CI [2.2, 8.1]). Across all ages 0-6 months, the baseline group reported shorter duration of any breastfeeding compared to intervention group p<0.0001.
Conclusion: The prevalence of EBF in Roatan is significantly below the global and Honduran national averages. EBF TCCMD resulted in a statistically significant increase in EBF for the first 2 months, as well as longer duration of any breastfeeding. As this study cannot rule-out a temporal trend, further study with a randomized trial would provide stronger evidence.
Comparing ultrasound-guided serratus anterior plane block with erector spinae plane block for postoperative analgesia in thoracic and breast surgery: A systematic review and meta-analysis
Authors: Zhang Wenfu , Wu Yingting , Huang Kuan , Zeng Mingwang , Yang Chao , Wang Lifeng , Xie Haiyu , Wang Yufei , Zhong Maolin , Ye Yifeng , Liang Weidong 
Published: January 2023

Abstract
Background: Serratus anterior plane block (SAPB) was first proposed in 2013 as a new method for regional nerve block, while erector spinae plane block (ESPB) was first proposed in 2016. Both regional nerve block techniques can be used for analgesia in thoracic and breast surgery, but the debate about their actual effects continues. The purpose of this systematic review was to compare the analgesic effects of these two nerve block techniques after thoracic and breast surgery.
Methods: We systematically searched the PubMed, Embase, Web of Science and Cochrane Library databases up to August 2022. We performed a meta-analysis of clinical randomized controlled trials (RCTs) comparing the effects of SAPB and ESPB on postoperative analgesia in patients undergoing thoracic and breast surgery. Results: A total of 11 RCTs were included. Meta-analysis revealed that compared with the SAPB group, patients in the ESPB group had significantly reduced 24-hour postoperative opioid consumption (standardized mean difference [SMD]: -0.76; 95% confidence interval [CI]: -1.29 to -0.24; P < 0.01; I2=88%). Rest or movement pain scores were significantly lower at various time points postoperatively. In addition, ESPB-group patients had significantly reduced intraoperative opioid consumption (SMD: -0.43; 95% CI: -0.64 to -0.23; P<0.001; I2=35%). In terms of time to first use of analgesics, ESPB significantly prolonged the time to first analgesic use (SMD: 3.53; 95% CI: 1.62 to 5.44; P < 0.001; I2 = 97%).
Conclusions: Compared with SAPB, ESPB is more effective in analgesia after thoracic and breast surgery, especially in thoracic surgery.
Evaluation of the Synergistic Antimicrobial activity of Amikacin with Norfloxacin against Pseudomonas aeruginosa isolated from buffaloes clinical mastitis
Authors: Abdelkhalek Hanaa . M , Abdelkhalek Hanaa M. , Nagib Hanan E , Elias Randa S , Mansour Saad S , Mousa Walid S. 
Published: January 2023

Abstract
Mastitis is a serious and economically problem commonly prevalent in most dairy cattle and buffaloes herds. Pseudomonas aeruginosa (P. aeruginosa) is opportunistic pathogens implicated in veterinary disorders including clinical mastitis in buffaloes. This study aimed to investigate the antibiogram pattern and synergistic effect of amikacin and norfloxacin against resistant P. aeruginosa isolates from mastitis origin. In addition, detection of some virulence and antibiotics resistance genes. Out of two hundred buffaloes, sixty (30%) were diagnosed as clinical mastitis according to inflammatory signs and the culture results reveled only 5 (8.3%) were P.aeruginosa. Most of P. aeruginosa exhibited resistance to most antimicrobials classes. Meanwhile, the minimal inhibitory concentration (MIC) for amikacin and norfloxacin is significantly reduced from 64 µg/mL to 1 µg/mL and from 256 µg/mL to 8µg/mL respectively with frictional inhibitory concentration (FIC) index 0.25. Therefore, the FIC index recognized a synergistic activity between amikacin and norfloxacin against all P.areuginosa isolates. The mPCR proved to be an efficient tool for detection of virulence genes (exoT, toxA, oprL, and isaI) at 152, 396, 504, 606 bp respectively. In addition, all the P.aeruginosa were found to carry the resistance genes (qnrS, qnrA, aadB). In conclusion, the combination of norfloxacin plus amikacin suppressed the resistance pattern P. aeruginosa isolates. Therefore, their combination showed synergistic bacterial potential antimicrobial activity in treatment of mastitis due to P. aeruginosa infection and help in reducing the resistance problem.
Comparative Efficacy of Terlipressin and Norepinephrine for Treatment of Hepatorenal Syndrome-Acute Kidney Injury (HRS-AKI): A Systematic Review and Meta-analysis
Authors: Olson Jody C. , Subramanian Ram M. 
Published: January 2023

Abstract
The treatment of choice for hepatorenal syndrome-acute kidney injury (HRSAKI) is vasoconstrictor therapy in combination with albumin, preferably norepinephrine or terlipressin as recommended by recent guidelines. However, larger head-to-head trials comparing the efficacy of terlipressin and norepinephrine have not been completed. Evaluation of smaller studies can provide insights needed to understand the comparative effects of these 2 medications. In this meta-analysis, we aimed to assess HRS reversal and 1-month mortality in subjects receiving terlipressin or norepinephrine for the management of HRSAKI. We searched literature databases, including PubMed, Cochrane EMBASE, and ResearchGate, for randomized controlled trials (RCTs) published in the last 15 years (2007–2022) that compare terlipressin plus albumin to norepinephrine plus albumin for the treatment of HRS-AKI in adults. We identified 7 RCTs that included a total of 376 subjects with HRSAKI or HRS type 1 and performed pairwise meta-analysis and network meta-analysis with the random effects model to estimate odds ratios (OR) for HRS reversal and 1-month mortality. We also examined additional outcomes of HRS recurrence, predictors of response, and incidence of adverse events (AEs). Network meta-analysis favored terlipressin for HRS reversal (OR 1.33, 95% confidence interval [CI]; [0.81–2.18] P = 0.2532) and short-term survival (OR 1.43, 95% CI [0.68–3.02]; P = 0.3450) though this benefit did not reach statistical significance. Terlipressin was associated with AEs such as abdominal pain and diarrhea, whereas norepinephrine was associated with cardiovascular AEs such as chest pain and ischemia. Most of the AEs were reversible with reduction in dose or discontinuation of therapy across both arms. Of the terlipressin-treated subjects, 5.3% discontinued therapy due to serious AEs compared to 2.7% of the norepinephrine-treated subjects. Although this analysis favors terlipressin, future studies can provide additional insight into the comparative efficacy of norepinephrine and terlipressin in the treatment of HRS-AKI, especially in the setting of acute-on-chronic liver failure.
Multi-depth Joint Entity Alignment Based on Textual InformationMulti-depth Joint Entity Alignment Based on Textual Information
Authors: guangsen ji , Yuchen Zhu , Yihan Wang , Yanbo Xu , Mei Li 
Published: January 2023

Abstract
Cross-lingual entity alignment is an important step in knowledge fusion, and its purpose is to determine whether two or more entities from different information sources refer to the same object in the real world. Recently, with the development of representation learning, many neural network-based entity alignment methods have been proposed. Existing embedding-based entity alignment methods embed entities from different information sources into a unified space, and then calculate the similarity between entity vector representations to find similar entities. Although the existing neural network-based methods have shown good performance on some public datasets, they also inherit some problems of neural networks, such as inexplicability and high model complexity, and most models are not suitable for the structural isomorphism of similar entity pairs is relatively high, which greatly limits the scalability of the model. Based on this, we propose our model on how to reduce the requirement for isomorphism—Multi-Depth Joint Entity Alignment Based on Text Information (MDJEA), which utilizes the name information and attribute information of entities, and simultaneously transforms the entity alignment problem into the allocation problem, which greatly improves the interpretability and robustness of the model, and can achieve alignment without training data. At the same time, we also combine the multi-depth information of the entity and combine the structural information at different depths to improve the alignment result. Experiments show that our method outperforms existing models by 2.7%-3.5% on each dataset.
Financial Inclusion of Vulnerable Sectors with a Gender Perspective: Risk Analysis Model with Artificial Intelligence Based on Complex Thinking
Authors: Vidal Adriana Medina , Alonso-Galicia Patricia Esther , González-Mendoza Miguel , Ramírez-Montoya María Soledad 
Published: January 2023

Abstract

The objective is to present a proposal for a gender-sensitive risk analysis model using artificial intelligence (AI) within the framework of complex thinking, specifically for impoverished and vulnerable women. This international non-parametric study analyzed business and entrepreneurial activity in a sample of 2,787 women. The methodological design included data analysis, the postulation of a proposed model, and a validation method for the credit risk analysis model. There is a correlation between the level of schooling of impoverished and vulnerable women with the possibility of self-employment and selling a product or service. In the framework of complex thinking, the perception of innovative thinking is related to the level of education and innovative decision-making in professional projects. Women with a higher level of schooling tend to think about their professional projects systematically. Promoting complex thinking involves innovative educational practices to encourage critical, systemic, scientific, and innovative thinking in entrepreneurship and sustainable development. Integrating reasoning for complexity benefits women and contributes to economic and social growth in vulnerable regions. In contrast to other models, our credit risk analysis model uses AI and variables for gender, vulnerability, and complex thinking to detect patterns in women's behaviors and attitudes in the venture start-up process.
Proteomics of long-term neurodevelopmental disorders of rats exposed to early pain stimulation in the neonatal period
Authors: Xu Jing , lv shuai , Zuo Yu , Feng Chunyang , Li Dong 
Published: January 2023

Abstract
Objective
To screen the feasibility and value of quantitative proteomic tandem mass spectrometry labeling (TMT) technology for early pain stimulation leading to neurodevelopmental disorders during puberty in neonatal rats.
Methods
The rats were randomly divided into two groups at postnatal day one (P1), and the skin was pricked for seven consecutive days in the experimental group; the control group was stroked simultaneously. A Morris water maze experiment was performed at P45 and P48. The rats were sacrificed at P50, and the proteins extracted from the hippocampal tissues were analyzed by TMT quantitative proteomics. The differentially expressed proteins were identified as biologically relevant proteins after pain intervention.
Results
The Morris water maze experiment suggested that the experimental group of rats had a significantly longer escape latency at P45 and P48 than the control group (P<0.05). At P49, Rats in the experimental group crossed the traversing platform less often than the control group within 60 s. Hippocampal tissue proteomics analysis showed than 33 proteins were upregulated, and 37 were downregulated. The differentially expressed proteins were enriched in different GO subsets, the most significant of which were sucrose metabolic process, response to stilbenoid maltose metabolic process, disaccharide metabolic process, circulating immunoglobulin complex, haptoglobin-hemoglobin complex, hemoglobin complex, replisome, purine-rich negative regulatory element binding, biliverdin reductase activity, alpha-1,4-glucosidase activity, and retinal dehydrogenase activity. KEGG enrichment analysis was most significant for starch and sucrose metabolism, galactose metabolism, antigen processing and presentation, and TGF-beta signaling. The core proteins were identified by constructing protein interaction networks. Four essential differentially expressed proteins were screened, including microtubule-associated serine-/threonine-protein kinase, carbonic anhydrase 3, F-box and leucine-rich repeat protein 4, and NADH-ubiquinone oxidoreductase chain 4L.
Conclusions
TMT-labeled proteomics identified energy metabolic processes, developmental processes, cellular processes, bioregulation, and signaling as the main targets of distant neurodevelopmental disorders caused by painful stimulation. Microtubule-associated serine/threonine-protein kinase, carbonic anhydrase 3, F-box and leucine-rich repeat protein 4, and NADH-ubiquinone oxidoreductase chain 4L may be involved in the cognitive impairment of adolescence caused by early pain stimulation in neonatal rats.
Association of Fusobacterium nucleatum in human saliva with periodontal status and composition of the salivary microbiome including periodontopathogens
Authors: Akase Takanori , Inubushi Junya , Hayashi-Okada Yoshiko , Shimizu Yasumitsu 
Published: January 2023

Abstract
Fusobacterium nucleatum promotes dental biofilm formation, increases the prevalence of periodontal disease, and is associated with systemic diseases such as colorectal cancer. However, the relationships of F. nucleatum in saliva with periodontal status and the composition of the salivary microbiome are unclear. Therefore, we analyzed these relationships in saliva samples collected from 611 subjects in Japan. Salivary DNA was extracted and the oral microbiome was analyzed using next-generation sequencing of 16S rRNA. The relationship between F. nucleatum and the community periodontal index was evaluated to examine effects on periodontal status, and α- and β-diversity were analyzed in three groups classified by relative abundance of F. nucleatum. Spearman rank correlation tests were used to examine relationships between the relative abundance of F. nucleatum and oral bacteria. Subjects with high levels of F. nucleatum had a higher prevalence of periodontitis compared with those with lower levels. β-diversity also differed between these two groups. F. nucleatum showed significant correlations with several periodontopathogens, including the red complex, P. intermedia, F. alocis and Fretibacterium ssp.. These results suggest that the relative abundance of F. nucleatum in saliva is associated with periodontal status and the composition of the salivary microbiome, including the red complex and periodontopathogens.
Verification of the therapeutic effects and neural mechanism of Bushen Zhuangjin Decoction in the treatment of knee osteoarthritis
Authors: Tan Xue , Zheng Danhao , Lin Qing , Wang Lili , Zhu Zaishi , Huang Yanfeng , Zeng Yihui , Mao Min , Yi Zhouping , Liu Linglong , Ma Dezun , Wang Jie , Li Xihai 
Published: January 2023

Abstract
Chronic pain is the principal clinical manifestation of knee osteoarthritis (KOA) and an essential indicator of the diagnosis and treatment effect. Changes in brain functional activity are related with chronic pain in KOA. Bushen Zhuangjin Decoction (BZD) has been proved to reduce inflammation of arthritis, improve cartilage degeneration and analgesia, but whether it plays a role through the change of brain function activity is not clear. Here, three experiments were performed: (1) network pharmacology evaluation to discover the potential targets of BZD to relieve pain in KOA; (2) verification of the therapeutic effects of BZD treatment on KOA pain with histomorphology, behavioral assessments, suspension chip analysis, and ultra-performance liquid chromatography/tandem mass spectrometry (UPLC-MS/MS) assays; and (3) functional magnetic resonance imaging to explore the effects of BZD treatment on brain function associated to KOA. The analgesic effect of BZD on KOA was found to be related to the neurotransmitters of pain signals through network pharmacology and the therapeutic effect of BZD on KOA pain was verified in vivo, and related to neuropeptides and neurotransmitters. Functional magnetic resonance imaging showed that BZD treatment could reverse the regional homogeneity/amplitude of low-frequency fluctuation analysis in pain-related brain regions of KOA, suggesting that the analgesic mechanism of BZD is related to neural regulation. This study confirmed the key position of pain-related neuromodulation mechanisms in the analgesic therapy of BZD and provide a theoretical basis for the treatment of KOA pain with BZD as a traditional Chinese medical.
A Case Report of Successful Treatment of Severe Immunotherapy-related Hepatitis in a Patient with advanced Lung Squamous-cell carcinoma
Authors: Zhou Haojie , Hou Anji , Liu Qing , Ai Luoyan , Zhan Mengna , Wu Jing , Wang Yan , Liu Tianshu 
Published: January 2023

Abstract
In the last decade, the use of immune checkpoint inhibitors (ICIs) targeting cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and programmed cell death protein 1 (PD-1) and its ligand (PD-L1) has significantly improved prognosis of patients with advanced malignant tumors (1). But immunotherapy-related adverse events (irAEs) were observed more often in the process of treatment(2). Immunotherapy-related adverse events may impair many organs, including endocrine system, skin, heart, lung, and liver. Though infrequent, irAEs may induce severe outcomes and influence subsequent therapy of cancer. Immunotherapy-related hepatitis (IRH) is one of the major irAEs. Reported incidence of IRH varies from 0.7–16%(3). Immunosuppressants are often considered when glucocorticoid does not respond well in treatment of IRH. There were reports of effective use of mycophenolate mofetil(4) and tacrolimus(5)in treatment of IRH. Infliximab is contraindicated for the treatment of IRH due to the risk of inducing further liver damage(6–8). However, benefits of these agents are uncertain when satisfactory effect of sufficient steroid was not seen. Reason may lie in complex situation of steroid resistant IRH. In this article, we reported a patient with lung squamous cell carcinoma who developed severe IRH after one cycle of PD-1 inhibitor. After comprehensive treatment of glucocorticoid, tofacitinib, artificial liver support system and other supportive treatments, the patient's liver function returned to normal.
The role of the absence of Hyrtl’s anastomosis in monochorionic pregnancy: friend or foe?
Authors: Ziling Liu , Jie Ruan 
Published: January 2023

Abstract
Background: Hyrtl’s anastomosis, an intra-arterial shunt, plays a protective role when the placental territories supplied by the umbilical arteries are different in size. Its absence is associated with an increased risk of poor outcomes in singleton pregnancy. However, the literature and studies on the effect of absent Hyrtl’s anastomosis in twin placentas are rare.
Case Presentation: We present a case of a monochorionic diamniotic(MCDA) twin pregnancy complicated with type I selective fetal growth restriction(SFGR). Despite discordance in placental territory and cord insertion sites, the patient had an overall good pregnancy process, suggesting that the absence of Hyrtl’s anastomosis may have played a benign role.
Conclusions: The absence of Hyrtl’s anastomosis in our case seemed to show a favorable effect, representing a finding of opposite effects in monochorionic placentas compared with singleton placentas.
Correlation between fatty liver index and estimated glomerular filtration rate in an elderly population in Yangzhou, China
Authors: Yong Jiacheng , liang lanyu , zhu fei , liu han , jiang rongli , liu chengyin , li li , lu guotao , yu xiaoping , jiao xiuping , shan Qing 
Published: January 2023

Abstract
OBJECTIVE: To investigate the correlation between fatty liver index (FLI) and estimated glomerular filtration rate (eGFR).
METHODS: We analyzed the correlation between fatty liver index (FLI) and estimated glomerular filtration rate (eGFR) in a cohort of elderly people who underwent physical examination at the Medical Examination Center of the Affiliated Hospital of Yangzhou University from 01/01/2020 to 12/31/2020, collected relevant data, and calculated the fatty liver index and estimated glomerular filtration rate.
RESULTS: A total of 7879 individuals were included in the analysis, and the results suggested that the probability of abnormal estimated glomerular filtration rate increased in the FLI≥30 group compared to the FLI<30 group, with abnormal estimated glomerular filtration rate of 66.37% and 62.19% in the two groups, respectively (P<0.001). Logistic regression analysis showed that the probability of abnormal estimated glomerular filtration rate increased by 0.7% for every 1 increase in FLI (OR=1.007, 95% CI 1.005-1.010, P<0.001).
CONCLUSION: Elevated FLI is associated with an increased risk of abnormalities in their estimated glomerular filtration rate in an elderly population in Yangzhou.