bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dissipation kinetics, risk assessment, and waiting period of spiromesifen on chili fruits using gas chromatography–electron capture detector
Authors: Dudwal Ramgopal , Jakhar Bhanwar Lal , Pathan Abdul Rashid Khan , Jan Ishrat , Kakralya Bajrang Lal , Dhaka Sis Ram , Kataria Alka , Yadav Amit Kumar , Choudhary Sandeep Kumar 
Published: December 2022

AbstractA supervised field trial was designed in Rajasthan Agricultural Research Institute, Durgapura, Jaipur, Rajasthan, to assess the dissipation and persistence of spiromesifen in chili fruits. Spiromesifen (22.9% suspension concentrate) was sprayed two times at an interval of 10 days at the recommended dose (96 g. a.i. ha−1) and double the recommended dose (192 g. a.i. ha−1) with four replications. Sampling was done according to the planned interval of days after the second spray. Extraction and cleanup were performed using the modified QuEChERS (quick,easy,cheap,effective,rugged, andsafe) method and the spiromesifen residue was analyzed by GC–electron capture detector and confirmation performed using GC–MS. The average initial deposit of spiromesifen was 1.207 mg kg−1and 1.948 mg kg−1at the recommended and double the recommended dose, respectively. The half‐life values of spiromesifen ranged between 2.7 and 3.2 days at the recommended and double the recommended dose. The safe waiting period was calculated for the respective doses and it was concluded that an average of 7 days is safe for picking. The FSSAI (Food Safety and Standards Authority of India) have set the maximum residue limit of 0.1 mg kg−1for spiromesifen in green chili. The theoretical maximum residue contribution value of spiromesifen was lower than the maximum permissible intake at both the applications on the 0th day. Hence, there will be no adverse effects on human health after consumption of green chilies.
The association between serum orexin A and short‐term neurological improvement in patients with mild to moderate acute ischemic stroke
Authors: Hu Shiyu , Ren Lijie , Wang Yang , Lei Zhihao , Cai Jingjing , Pan Suyue 
Published: December 2022

AbstractBackgroundThe serum orexin A level was significantly lower among patients with acute ischemic stroke (AIS) and negatively related to the volume of the infarction, but the relationship between serum orexin A and prognosis of AIS was still unclear. We aimed to clarify the association between serum orexin A and the short‐term neurological improvement in patients with mild to moderate AIS.MethodsWe consecutively enrolled patients with first ever mild to moderate AIS admitted to hospital within 48 h from symptom onset in this prospective observational study. The serum orexin A concentrations were determined on the second morning since the admission. The short‐term neurological improvement was defined as more than 1 point decrease in the National Institute of Health Stroke Scale score within 7 days after admission.ResultsWe detected increased serum orexin A level in mild to moderate AIS patients with early onset of stroke‐related insomnia (33.44 vs 18.66 pg/ml,p = .004) as well as in patients with short‐term neurological improvement compared to those without improvement (31.78 vs 16.24 pg/ml,p = .038). The serum orexin A level was positively associated with the short‐term neurological improvement after adjusting for sleep condition and other related variables.ConclusionSerum orexin A might be a useful biomarker for the assessment of early prognosis in patients with mild to moderate AIS.
Boards of directors and environmental sustainability: Finding the synergies that yield results
Authors: Villalba‐Ríos Paula , Barroso‐Castro Carmen , Vecino‐Gravel Julio Darío , Villegas‐Periñan María del Mar 
Published: December 2022

AbstractBoards of directors play an important role in one of the biggest challenges facing companies today: environmental sustainability. While research has mainly focused on the individual and isolated impacts of board composition characteristics on environmental sustainability, we aim to provide an understanding of what combinations of these characteristics result in its high/low levels and why. Using a fuzzy‐set qualitative comparative analysis of a Spanish company's sample over the period 2014–2019, we find that the characteristics of board composition could be complemented or substituted among them, having a similar impact on environmental sustainability performance. We also find that large boards, with a high presence of women and a low presence of family members, led to high environmental sustainability while having no dedicated sustainability committee and a lack of independence with no family presence yielded a low one. Finally, we draw four strategies for the design of the board composition.
Genotypic and Phenotypic Diversity of Endemic Golden Camellias Collected from the North of Vietnam
Authors: Van‐Anh Le T. , Mai Nga T. P. , Nhi Nguyen P. , Kieu‐Oanh Nguyen T. 
Published: December 2022

AbstractGolden Camellias have recently been used as a food, cosmetic, and traditional medicine in China and Vietnam. Forty‐two species have natural distribution in Vietnam, of which thirty‐two species were considered endemic species of this country. The morphology of leaves and flowers of these species were similar; therefore, their taxonomic identification usually needed experts and the authentication has often been confused among species. Our study aims to describe the genetic diversity and the relationship of six species Camellia phanii, Camellia tamdaoensis, Camellia tienii, Camellia flava, Camellia petelotii and Camellia euphlebia by using three chloroplast DNA‐barcodes: matK, rbcL and trnH‐psbA. We also clarified the significant differences in anatomical characteristics of midvein and blade of their leaves, which suggested the possibility to use these criteria in taxonomy. In addition, preliminary chemical profiles of the methanolic extracts of leaves from six Golden Camellias such as total phenolic content (TPC), total flavonoid content (TFC), total anthocyanin content (TAC) and chlorogenic acids content (TCGAs) also showed the diversity among them. Interestingly, the discrimination on the catechins profile among six species followed the same tendency with the genetic distance on the phylogeny tree suggesting that catechins (i. e., discriminative catechins) can be biomarkers for the chemotaxonomy of these six Golden Camellias.
6‐Gingerdione Reduces Apoptotic Conditions in HepG2 Cells and Inhibits Inflammatory Cytokine Gene Expression in Alcoholic Liver Injured Zebrafish Larvae
Authors: Guru Ajay , Manjunathan Tamilvelan , Sudhakaran Gokul , Juliet Annie , Gopinath Pushparathinam , Arockiaraj Jesu 
Published: December 2022

AbstractAntioxidant natural products and their analogs especially phenolic compounds, exhibit diverse biological properties, including anti‐inflammatory, antioxidant, and anticancer activities. Ginger which is widely used worldwide for various beneficial effects also contains several phenolic antioxidants, and 6‐gingerol is one of the natural products studied extensively. However, the molecular mechanism of synthetically synthesized 6‐gingerdione (compound 1) from 6‐gingerol was not known. In this study, compound 1 and methylated 6‐gingerdione (compound 2) were obtained semi synthetically from 6‐gingerol. Compound 1 and 2 are subjected to SwissADME prediction. Then the protective effect of compound 1 was analyzed in 2 % EtOH induced HepG2 cells and zebrafish larvae. Hydroxyl and nitric oxide scavenging assays reveal that compound 1 showed more antioxidant activity than compound 2 at 50 μM. Moreover, compound 1 exhibited good anti‐inflammatory activity via lipoxygenase inhibition and proteinase inhibition. Apoptosis and oxidative stress in HepG2 cells were induced by 2 % EtOH and treated with compound 1. Compound 1 significantly inhibited the EtOH induced nitric oxide production, apoptosis, and ROS generation in HepG2 cells. Encouraged by the in‐vitro antioxidant and anti‐inflammatory activities, compound 1 was then investigated for its protective effect in 2 % EtOH induced ALD zebrafish larva. Compound 1 protected the zebrafish larvae from liver injury by suppressing inflammatory (COX‐2, TNF‐α, and IL‐1β) and lipogenic genes (C/EBP‐α, SREBP1, and IL‐1β) while upregulating the antioxidant gene. Our findings indicate that compound 1 synthesized from 6‐gingerol ameliorated liver injury that likely, contributes to its potential antioxidant and anti‐inflammatory properties.
Design, Synthesis, and Biological Activity of Guaiazulene Derivatives
Authors: Ma Zongchen , Han Xiao , Ren Junde , Liu Kun , Zhang Wenjie , Li Guoqiang 
Published: December 2022

AbstractGuaiazulene and related derivatives were famous for diverse biological activities. In an effort to discover new highly efficient candidate drugs derived from guaiazulene, four series of guaiazulene derivatives were designed, synthesized, and evaluated for antiproliferation, antiviral, anti‐inflammatory and peroxisome proliferators‐activated receptor γ (PPARγ) signalling pathway agonist activities. Among them, two guaiazulene condensation derivatives showed selective cytotoxic activities towards K562 cell with IC50 values 5.21 μM and 5.14 μM, respectively, accompanied by slight effects on normal cell viability. For the first time, one guaiazulene derivative from series I exhibited potent antiviral activity towards influenza A virus with IC50 of 17.5 μM. A guaiazulene‐based chalcone showed higher anti‐inflammatory activity than positive drug indomethacin with an inhibitory rate of 34.29 % in zebrafish model in vivo. One guaiazulene‐based flavonoid could strongly agitate PPARγ pathway at 20 μM, indicating the potential of guaiazulene derivatives to reduce obesity development and ameliorate hepatic steatosis. Preliminary in silico ADME studies predicted the excellent drug‐likeness properties of bioactive guaiazulene derivatives.
Synthesis and Biological Evaluation of Substituted Pyrazole‐Fused Oleanolic Acid Derivatives as Novel Selective α‐Glucosidase Inhibitors
Authors: Gao Mei , Ma Hui , Liu Xiaoyu , Zhang Yanhua , Tang Liansheng , Zheng Zhiyong , Zhang Xinlei , Jiang Chengshi , Lin Lin , Sun Haiji 
Published: December 2022

AbstractA series of novel substituted pyrazole‐fused oleanolic acid derivative were synthesized and evaluated as selective α‐glucosidase inhibitors. Among these analogs, compounds 4a–4f exhibited more potent inhibitory activities compared with their methyl ester derivatives, and standard drugs acarbose and miglitol as well. Besides, all these analogs exhibited good selectivity towards α‐glucosidase over α‐amylase. Analog 4d showed potent inhibitory activity against α‐glucosidase (IC50=2.64±0.13 μM), and greater selectivity towards α‐glucosidase than α‐amylase by ∼33‐fold. Inhibition kinetics showed that compound 4d was a non‐competitive α‐glucosidase inhibitor, which was consistent with the result of its simulation molecular docking. Moreover, the in vitro cytotoxicity of compounds 4a–4f towards hepatic LO2 and HepG2 cells was tested.
Longitudinally extensive transverse myelopathy in spinal cord infarction
Authors: Chiew Yi Rong , Tan Jeanne May May 
Published: December 2022

AbstractSpinal cord infarction may present as longitudinally extensive myelopathy, similar to inflammatory myelitis such as neuromyelitis optica. Magnetic resonance imaging features such as diffusion‐weighted imaging/apparent diffusion coefficient showing restricted diffusion and lack of contrast enhancement are helpful in the diagnosis of spinal cord infarction and differentiating them from inflammatory myelitis.
Two cases of parapharyngeal space tumor resected by a double split mandibular osteotomy technique
Authors: Kato Shinichiro , Ijichi Kei , Fukushima Asako , Nakamura Tomohisa , Takashima Hiroyuki , Nabeta Tsuyoshi , Miyamoto Hironori , Ishibashi Kenichiro , Tsuchiya Shuhei , Hishida Sumiyo , Shibuya Yasuyuki 
Published: December 2022

AbstractParapharyngeal space tumors have poor subjective symptoms and often grow until diagnosed; therefore, mandibular transection may be needed to obtain a wider field of view during surgery. However, if a median lower lip incision is performed for the mandibular transection, esthetic problems occur after surgery. Here, we report two cases of parapharyngeal space tumors that were removed with a mandibular lateral segment‐osteotomy technique without median lower lip incision to avoid esthetic problems. Case 1 was a 49‐year‐old woman. She was aware of a right tonsillar swelling, and an imaging test revealed a tumor lesion 60 mm in size in the right parapharyngeal space. Case 2 was a 40‐year‐old woman with an abnormal position of the uvula, and an imaging test showed the left parapharyngeal space tumor lesion 45 mm in size. Both cases were diagnosed as a pleomorphic adenoma, and surgery under general anesthesia was performed jointly with otolaryngology and oral surgery. The incision was performed from the lower part of the right auricle to the anterior part of the submandibular area. After the tumor resection, the mandible was repositioned, fixed by plates, and the intermaxillary fixation was performed with a surgical stent. In both cases, slight paralysis of the mandibular branch of the facial nerve and the mental nerve was observed after the operation, but they were improved immediately. One year after the operation, the plates were removed. There have been no recurrences until now.
Wideband to narrowband/dual band characteristics of monopole antenna using frequency selective surfaces
Authors: Mondal Rahul , Reddy P. Soni , Sarkar Sushanta , Chanda Sarkar Debasree , Sarkar Partha Pratim 
Published: December 2022

SummaryA monopole antenna having desirable transmission characteristics with high gain is proposed. The monopole antenna comprises 45° tilted square shaped patch and modified rectangular metallic ground plane on FR4 dielectric substrate. The proposed monopole antenna operates from 2.6 GHz to 9.7 GHz with maximum peak gain of 2.3 dBi. Now, a dual‐layer aperture‐type FSS is designed having a passband from 5.9 GHz to 9.2 GHz and incorporated with the proposed monopole antenna. Thus, the combination only covers the selective frequency band from 5.5 GHz to 8.7 GHz with a stable gain of around 5 dBi. Second, another FSS is designed, which has one stop‐band from 4.1 GHz to 5.4 GHz and two passbands on the both sides of this stop‐band. This combination does not work from 4.1 GHz to 5.5 GHz but covers dual band from 2.48 GHz to 3.3 GHz with a peak gain of 5 dBi and 5.5 GHz to 10 GHz with a peak gain of 5.5 dBi. Therefore, without modifying the antenna design, any tunable transmission band can be achieved by the proposed combination. The proposed antenna and FSS combination structure may be suitable for military wireless applications for its band selection characteristics.
Cost‐saving population genomic investigation of Daphnia longispina complex resting eggs using whole‐genome amplification and pre‐sequencing screening
Authors: Nickel Jana , Cordellier Mathilde 
Published: December 2022

AbstractResting stages of aquatic organisms that accumulate in the sediment over time are an exceptional resource that allows direct insights into past populations and addressing evolutionary questions. This is of particular interest in taxa that face relatively new environmental challenges, e.g., climate change and eutrophication, such as the Daphnia longispina species complex, a keystone zooplankton group in European freshwater ecosystems. However, genomic analysis might be challenging as DNA yield from many of these resting stages can be low and the material degraded. To reliably allow the resequencing of single Daphnia resting eggs from different sediment layers and characterize genomic changes through time, we performed whole‐genome amplification to obtain DNA amounts suitable for genome resequencing and tested multiple protocols involving egg isolation, whole‐genome amplification kits, and library preparation. A pre‐sequencing contamination screening was developed, consisting of amplifying mitochondrial Daphnia and bacterial markers, to quickly assess and exclude possibly contaminated samples. In total, we successfully amplified and sequenced nine genomes from Daphnia resting eggs that could be identified as Daphnia longispina species. We analyzed the genome coverage and heterozygosity of these samples to optimize this method for future projects involving population genomic investigation of the resting egg bank.
Multifunctional polyimides for resistive switching memory devices based on flexible transparent polyimide–silver nanowires hybrid electrodes
Authors: Liu Guoshu , Zhang Jinghong , She Zuxin , Peng Liangyi , Qu Lunjun , Wang Kaiti , Tang Hailong , Yang Chaolong 
Published: December 2022

AbstractWith the quick development of flexible memory electronics, multifunctional organic materials have been the necessary for fabricating electronics. In this work, the highly transparent and flexible electrode was successfully prepared by coating the high‐performance silver nanowires (AgNWs) onto the colorless polyimide (PI) substrate. The prepared flexible PI–AgNWs electrodes exhibited a relatively low sheet resistance of 15 Ω/sq with the high transparency of 68% at the wavelength of 400 nm. A novel kind of polyimide TPC6FPI was successfully synthesized and characterized with the excellent thermostability and high glass transition temperature (Tg) above 250°C. Furthermore, a kind of flexible transparent PI–AgNWs/TPC6FPI/Al resistive memory device was prepared and exhibited good SRAM switching behavior with the threshold voltage of around 2.1 V and the ON/OFF current ratio of ˜104, which indicated that multifunctional PI‐based memory device showed the potential to the wearable devices.
Platinum‐group mineral and silicate inclusions in the low‐Al chromitites of the Manipur ophiolite, northeast India: Implications on Cr‐PGE mineralization in nascent subduction zone settings
Authors: Singh Toijam Bapin , Maibam Bidyananda , Kapsiotis Argyrios 
Published: December 2022

Low‐Al chromitites from the Manipur ophiolite contain a wide range of mineral inclusions, including hydrous and anhydrous silicates, sulphides, and platinum group minerals (PGM). The common inclusions are primary silicates, such as clinopyroxene, orthopyroxene and secondary silicate inclusions, such as chlorite, serpentine, and garnet. These inclusions are small (<30 μm in PGM, <100 μm in silicates) and randomly distributed throughout their host chromite grains. The shape and texture indicate some inclusions (clinopyroxene, orthopyroxene, PGMs) trapped during the magmatic stage and most inclusions (chlorite, serpentine, and uvarovite) trapped during recrystallization of chromite. Clinopyroxene was discrete inside the chromite, with Cr2O3 content ranging from 0.62 to 1.77 wt.%, and Al2O3 varying between 0.96 to 1.63 wt.%. Orthopyroxene is enstatite (En93Wo2Fs4), Cr2O3 varies from 0.58 to 1.8 wt.% and the minor amount of CaO (0.41–0.81 wt.%), and Al2O3 (0.58–0.83 wt.%). Uvarovite is present in two forms: discrete crystal inclusions (anhydrous) in chromites and fractures (hydrous) as fillings. The chlorite occurs as lath shaped, and patchy phase is Cr‐rich variety ‐ kammererite (clinochlore) and penninite with variable Cr2O3 (0.22–7.25 wt.%) and FeO (2.5–3.9 wt.%). The PGM in the studied chromite are laurite (Ru, Os, Ir)S2. The parental melts of chromitites had low TiO2 (0.16–0.48 wt.%) and Al2O3 (10.18–14.58 wt.%) contents, and primary mineral inclusions, suggesting an arc‐like geochemical affinity, and the estimated melt composition is comparable with that of boninitic magma.
Mother's functional difficulty is affecting the child functioning: Findings from a nationally representative MICS 2019 cross‐sectional survey in Bangladesh
Authors: Anjum Aniqua , Ahammed Tanvir , Hasan Md Mahedi , Chowdhury Muhammad Abdul Baker , Uddin Md. Jamal 
Published: December 2022

AbstractBackgroundFunctional difficulties in children can be transmitted from mother to child, which is a major concern. We sought to determine whether there was a correlation between a mother's functional difficulty and functional difficulty in kids between the ages of 2–4 and 5–17. We also want to evaluate other fundamental aspects that influence on child's functionality.MethodsWe used Multiple Indicator Cluster Survey (MICS) data sets. For two different age groups, the children's difficulty status was evaluated. The sociodemographic factors served as explanatory variables in this study. We used χ2 tests and survey logistic regression models to analyze the data.ResultsFunctional difficulties were less common in children aged 2–4 years (2.78%) but 8.27% in those aged 5–17 years. The study specifies that the mother's functional difficulty (odds ratio [OR]: 2.66, confidence interval [CI]: 1.35–5.24 for children aged 2–4 years and OR: 3.36, CI: 2.80–4.03 for children aged 5–17 years) were significantly associated with the functional difficulty of both age groups' children. Not attending early childhood education programs (OR: 1.89, CI: 1.16–3.10 for children aged 2–4 years and OR: 2.66, CI: 2.19–3.22 for children aged 5–17 years) and divisions were also significantly affecting the functional difficulty of both age groups' children. Moreover, area of residence and gender were significant factors for the older age group.ConclusionsThe prevalence of difficulty among children in Bangladesh is high. Children's functional difficulty, regardless of age, is greatly influenced by the functional difficulty of their mothers, their absence from early childhood education programs, and divisions. Reducing the prevalence of child functioning difficulties will be more successful if the government and NGOs consider these factors while developing appropriate intervention programs.
Estimating the scale parameter of the norming constants method in analysing nonstationary annual maximum floods
Authors: Xu Wentao , Xiong Lihua , Yan Lei , Dong Linyao , Jiang Cong , Xu Chong‐Yu 
Published: December 2022

AbstractIn frequency analysis of annual maximum flood series (AMFS), it is mechanism‐based and significant to incorporate the information of the underlying “ordinary” daily streamflow events for improving accuracy of flood risk estimation and appropriate management. In previous studies related to flood nonstationarity, the classical norming constants method (C‐NCM) has been used to derive statistical parameters of annual maximum flood distribution from daily streamflow distribution. However, C‐NCM does not flexibly consider the feasible range of the scale parameter of annual maximum flood distributions, which can result in the inability to provide sufficient and reliable models to fit AMFS. This paper aims to investigate the potential of two alternative norming constants methods in fitting annual maximum floods, namely the Hall's norming constants method (H‐NCM) and the Fisher and Tippetts' norming constants method (FT‐NCM) respectively. A comparative study of these three methods was carried out using hydrological streamflow series of 77 stations in the Yangtze and Yellow River basins, China. The results found that H‐NCM outperforms both C‐NCM and FT‐NCM for the stations with relatively low‐skewness coefficient of AMFS. Therefore, H‐NCM is recommended to prioritize for practical applications when considering daily streamflow rather than small samples of flood events. Furthermore, if the skewness coefficient exceeds Cs,Gumbel≈1.14, the overall modelling performance of these three methods is significantly deteriorated. This can provide some reference for the applicability of the norming constants method in flood frequency analysis.