bluuebunny/crossref_metadata_2025_split huggingface dataset:
Trends in research on dietary behavior and cardiovascular disease from 2002 to 2022: a bibliometric analysis
Authors: Wang Jie , Yu Qingsong , Liu Nannan , Nie Kaidi , Sun Xiaofang , Xia Lina 
Published: June 2023

BackgroundDietary behaviors and cardiovascular disease are two major health issues that have attracted a lot of attention from researchers worldwide. In this study, we aimed to provide a comprehensive analysis of the publication trends, authorship patterns, institutional affiliations, country/region contributions, journal outlets, highly cited documents, and keyword clusters in the field of dietary behaviors and cardiovascular disease research over the past two decades.MethodsWe conducted a systematic literature review of peer-reviewed articles published from 2002 to 2022 in the Web of Science Core Collection database. We extracted and analyzed data on the annual publication volume, authorship patterns, institutional affiliations, country/region contributions, journal outlets, highly cited documents, and keyword clusters using bibliometric methods and visualization tools.ResultsOur study analyzed 3,904 articles, including 702 reviews and 3,202 research articles. The results revealed a continuous increase in the number of publications in this field over the past two decades. The top 10 authors, institutions, and countries/regions with the highest publication output were identified, indicating the leading contributors to this field. Moreover, the most frequently cited documents and highly clustered keywords were identified, providing insights into the research themes and topics in this field.ConclusionOur study provides a comprehensive analysis of the publication trends, authorship patterns, institutional affiliations, country/region contributions, journal outlets, highly cited documents, and keyword clusters in the field of dietary behaviors and cardiovascular disease research over the past two decades. The findings provide valuable information for researchers, policymakers, and stakeholders to understand the research landscape, identify research gaps, and develop future research directions in this field.
Application of 18F-FDG PET/CT imaging in gallbladder inflammatory pseudotumor with elevated CA199: a case report and review of literature
Authors: Shao Mingyan , Xu Rong , Qi Wanling , Luo Zhehuang , Liao Fengxiang , Fan Sisi 
Published: June 2023

BackgroundGallbladder inflammatory pseudotumor (GIPT) is a nonspecific chronic proliferative inflammation of the gallbladder. At present, the pathogenesis is not clear, which may be related to bacterial and viral infections, congenital diseases, gallstones, chronic cholangitis and so on. GIPT is rare and the imaging examination has no obvious specificity. There are few reports on the 18F-FDG PET/CT imaging characteristics of GIPT. In this paper, 18F-FDG PET/CT findings of GIPT with elevated CA199 are reported and the literature is reviewed.Case descriptionA 69-year-old female patient presented with recurrent intermittent right upper abdominal pain for more than 1 year, followed by nausea and vomiting for 3 hours, without fever, dizziness, chest tightness and other symptoms. Complete CT, MRI, PET/CT and related laboratory tests, CEA (-), AFP (-), Ca199 224.50U/mL ↑,18F-FDG PET/CT images showed uneven thickening at the bottom of the gallbladder, slightly increased gallbladder volume, eccentric and localized thickening of the gallbladder body wall, nodular soft tissue density shadow, clear boundary, smooth gallbladder wall, presence and smooth hepatobiliary interface, increased FDG radioactivity uptake, SUVmax was 10.2.The tumor was resected after operation and was diagnosed as gallbladder inflammatory pseudotumor by postoperative pathology.Conclusion18F-FDGPET/CT imaging has a certain significance for gallbladder inflammatory pseudotumor. In patients with chronic cholecystitis, when the CA199 increases, the gallbladder wall appears localized thickening, the hepatobiliary interface exists and is smooth, and the 18F-FDG metabolism is mildly to moderately increase. Gallbladder cancer cannot be diagnosed alone, and the possibility of gallbladder inflammatory pseudotumor should also be considered. However, it should be noted that the cases with unclear diagnosis should still be actively treated with surgery, so as not to delay the treatment opportunity.
Clinical features and prognosis of lung cancer in patients with connective tissue diseases: a retrospective cohort study
Authors: Li Ningning , Gao Liwei , Bai Chunmei , Zhao Lin , Shao Yajuan 
Published: June 2023

BackgroundStudies have demonstrated a close association between connective tissue diseases (CTDs) and lung cancer (LC). Evidence supports that poor survival may be associated with the presence of CTDs in patients with LC.MethodsThis retrospective cohort study investigated 29 patients with LC with CTDs, and 116 patients with LC without CTDs were enrolled as case-matched control cohorts. Medical records, therapeutic efficacy of cancer, and outcomes were analyzed.ResultsThe median duration from the diagnosis of CTDs to LC was 17 years. The Eastern Cooperative Oncology Group (ECOG) performance score for LC-CTD patients was worse than that for matched non-CTD LC patients. The median progression-free survival (mPFS) and overall survival (mOS) of first-line chemotherapy did not differ between patients with lung adenocarcinoma (AC) with and without CTDs. A significant difference was observed in mPFS [4 months vs. 17 months; hazard ratio (HR), 9.987; p = 0.004] and mOS (6 months vs. 35 months; HR, 26.009; p &lt; 0.001) of first-line epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) treatment between patients with AC with and without CTDs. The presence of CTD, sex, ECOG performance status, and tumor-node-metastasis clinical stage were the independent prognostic factors in all patients with non–small cell LC (NSCLC). ECOG performance status was determined to be an independent prognostic factor in patients with LC-CTD. In patients with NSCLC with CTD (n = 26), sex (male) and worse ECOG score were the independent poor prognostic factors.ConclusionsCTDs were associated with poor survival in patients with LC. The therapeutic efficacy of first-line EGFR-TKI therapy was significantly worse in patients with lung AC with CTDs than in those without CTDs. ECOG performance status was determined as an independent prognostic factor for patients with LC and CTDs.
Serum total bile acid levels assist in the prediction of acute intussusception with abdominal type Henoch-Schonlein purpura in children
Authors: Yu Sijie , Feng Wei , Wang Yi , Zhao Maoyuan , Tu Yuying , Guo Zhenhua 
Published: June 2023

BackgroundThe severe acute abdomen associated with Henoch-Schonlein purpura (HSP) is an acute intussusception (AI). There is no reliable specific marker for AI with abdominal-type HSP. The serum total bile acid (TBA) level is a new prognostic marker associated with the severity of intestinal inflammation. The purpose of this study was to identify the prognostic value of serum TBA levels for the diagnosis of AI in children with abdominal-type HSP.MethodsA retrospective study of 708 patients with abdominal-type HSP was conducted, with demographic data, clinical symptoms, hepatic function index, immune function markers, and clinical outcomes assessed. Patients were divided into two groups: HSP (613 patients) and HSP with AI (95 patients). The data were analysed using SPSS 22.0.ResultsOf the 708 patients, the serum TBA levels were higher in the HSP with AI group than in the HSP group (P &lt; 0.05). Logistic regression analysis showed that vomiting (OR = 396.492, 95% CI = 14.93–10,529.67, P &lt; 0.001), haematochezia (OR = 87.436, 95% CI = 5.944–1,286.214, P = 0.001), TBA (OR = 16.287, 95% CI = 4.83–54.922, P &lt; 0.001), and D-dimer (OR = 5.987, 95% CI = 1.892–15.834, P = 0.003) were independent risk factors for abdominal-type HSP with AI. Receiver operating characteristic (ROC) curve analysis showed that the optimal cut-off serum TBA value (sensitivity = 91.58%, specificity = 84.67%, AUC = 93.6524%) was &gt;3 μmol/L for predicting AI in children with abdominal-type HSP. In this group of HSP patients with AI, a serum TBA level ≥6.98 μmol/L was significantly associated with an increased incidence of operative treatment (51.85% vs. 75.61%, P = 0.0181), intestinal necrosis (9.26% vs. 29.27%, P = 0.0117), and length of hospital stay [15.76 ± 5.31 vs. 10.98 ± 2.83 (days), P &lt; 0.0001].ConclusionIn children with HSP and AI, the serum TBA level was significantly higher. A novel but promising haematological indicator, the serum TBA level, helps identify HSP with and without AI and predicts intestinal necrosis in HSP with AI.
Incidence and impact of antiplatelet therapy cessation among very older patients with stable coronary artery disease
Authors: Zou Xiao , Wang Liang , Sun Sha-Sha , Hu Yi-Xin , Liu Hong-Wei , Wang Hao , Cao Jian , Liu Hong-Bin , Fan Li 
Published: June 2023

Objectives: Long-term use of evidence-based antiplatelet therapy is recommended for management of stable coronary artery disease (SCAD). However, non-adherence to antiplatelet drugs is common in older patients. This study aimed to evaluate the incidence and impact of antiplatelet therapy cessation on clinical outcomes of older patients with SCAD.Methods: A total of 351 consecutive eligible very older patients (≥80 years) with SCAD from the PLA General Hospital were included. Baseline demographics, clinical characteristics, and clinical outcomes were collected during follow-up. Patients were divided into cessation group and standard group based on whether discontinuing of antiplatelet drugs. The primary outcome was major adverse cardiovascular events (MACE) and secondary outcomes were minor bleeding and all-cause mortality.Results: A total of 351 participants, with a mean age of 91.76 ± 5.01 years old (range 80–106 years) were included in statistical analysis. The antiplatelet drug cessation rate was 60.1%. There were 211 patients in cessation group and 140 patients in standard group. During a median follow-up of 98.6 months, the primary outcome of MACE occurred in 155 patients (73.5%) in the cessation group and 84 patients (60.0%) in the standard group (HR = 1.476, 95% CI:1.124-1.938, p = 0.005). Cessation of antiplatelet drugs increased the rates of angina (HR = 1.724, 95% CI:1.211-2.453, p = 0.002) and non-fatal MI (HR = 1.569, 95% CI:1.093-2.251, p = 0.014). The secondary outcomes of minor bleeding and all-cause mortality were similar between the two groups.Conclusion: Among very older patients with SCAD, antiplatelet therapy cessation significantly increased the risk of MACE, and continuous antiplatelet drug therapy didn’t increase the risk of minor bleeding.
TMS-evoked potential in the dorsolateral prefrontal cortex to assess the severity of depression disease: a TMS-EEG study
Authors: Li Xingxing , Chen Meng , Liu Qinqin , Zheng Chao , Yu Chang , Hou Guangwei , Chen Zan , Chen Yiqing , Chen Yinping , Zhu Guidong , Zhou Dongsheng , Xu Weiqian 
Published: June 2023

Objective: The combined use of transcranial magnetic stimulation and electroencephalography (TMS-EEG), as a powerful technique that can non-invasively probe the state of the brain, can be used as a method to study neurophysiological markers in the field of psychiatric disorders and discover potential diagnostic predictors. This study used TMS-evoked potentials (TEPs) to study the cortical activity of patients with major depressive disorder depression (MDD) and the correlation with clinical symptoms to provide an electrophysiological basis for the clinical diagnosis.Methods: A total of 41 patients and 42 healthy controls were recruited to study. Using TMS-EEG techniques to measure the left dorsolateral prefrontal cortex (DLPFC) ‘s TEP index and evaluate the clinical symptoms of MDD patients using the Hamilton Depression Scale-24 (HAMD-24).Results: MDD subjects performing TMS-EEG on the DLPFC showed lower cortical excitability P60 index levels than healthy controls. Further analysis revealed that the degree of P60 excitability within the DLPFC of MDD patients was significantly negatively correlated with the severity of depression.Conclusion: The low levels of P60 exhibited in DLPFC reflect low excitability in MDD; the P60 component can be used as a biomarker for MDD in clinical assessment tools.
Sensitivity to nuclear data of the design of the IFMIF-DONES beam dump
Authors: Lopez Victor , Ogando Francisco , Sauvan Patrick 
Published: June 2023

During the commissioning and start-up phases of IFMIF-DONES, the 40 MeV deuteron beam will be stopped in a conical beam stopper made of copper, giving rise to intense neutron fields. Accurate coupled deuteron-neutron transport simulations are required in order to prevent the potential risks to the workers and equipment involved. However, the experimental data concerning the neutron emission under these circumstances is scarce and limited to a particular range of energies. Different deuteron nuclear data libraries such as JENDL-5 and special files of TENDL-2021 exhibit some differences on the spectrum of the emitted neutrons. The differences are present in the high energy tails, beyond the available experimental data. Calculations of the prompt neutron fields have been performed employing both deuteron data libraries, as well as employing an estimation of the neutron energy-angle distribution derived from experimental data at different irradiation energies. Even though the high energy tails represent a small part of the flux, they have a major impact on the dose rates. The disparity of the results evinces large uncertainties in the IFMIF-DONES beam dump design process. Further experiments are required in order to resolve the differences among nuclear data libraries and reduce the uncertainty.
Cultivar-dependent differences in tuber growth cause increased soil resistance in potato fields
Authors: Skilleter Patrick , Nelson David , Dodd Ian C. 
Published: June 2023

Since soil compaction of potato fields delays shoot emergence and decreases total yield, the causes and effects of this compaction need to be better understood. In a controlled environment trial with young (before tuber initiation) plants, roots of cv. Inca Bella (a phureja group cultivar) were more sensitive to increased soil resistance (3.0 MPa) than cv. Maris Piper (a tuberosum group cultivar). Such variation was hypothesized to cause yield differences in two field trials, in which compaction treatments were applied after tuber planting. Trial 1 increased initial soil resistance from 0.15 MPa to 0.3 MPa. By the end of the growing season, soil resistance increased three-fold in the upper 20 cm of the soil, but resistance in Maris Piper plots was up to twice that of Inca Bella plots. Maris Piper yield was 60% higher than Inca Bella and independent of soil compaction treatment, whilst compacted soil reduced Inca Bella yield by 30%. Trial 2 increased initial soil resistance from 0.2 MPa to 1.0 MPa. Soil resistance in the compacted treatments increased to similar, cultivar-dependent resistances as trial 1. Maris Piper yield was 12% higher than Inca Bella, but cultivar variation in yield response to compacted soil did not occur. Soil water content, root growth and tuber growth were measured to determine whether these factors could explain cultivar differences in soil resistance. Soil water content was similar between cultivars, thus did not cause soil resistance to vary between cultivars. Root density was insufficient to cause observed increases soil resistance. Finally, differences in soil resistance between cultivars became significant during tuber initiation, and became more pronounced until harvest. Increased tuber biomass volume (yield) of Maris Piper increased estimated mean soil density (and thus soil resistance) more than Inca Bella. This increase seems to depend on initial compaction, as soil resistance did not significantly increase in uncompacted soil. While increased soil resistance caused cultivar-dependent restriction of root density of young plants that was consistent with cultivar variation in yield, tuber growth likely caused cultivar-dependent increases in soil resistance in field trials, which may have further limited Inca Bella yield.
Economic evaluation of tele-resuscitation intervention on emergency department pediatric visits in the Niagara Region, Canada a pilot study
Authors: Pace A. , Faught B. E. , Law M. , Mateus L. , Roy M. , Sulowski C. , Khowaja A. 
Published: June 2023

IntroductionThe use of telemedicine in critical care is emerging, however, there is a paucity of information surrounding the costs relative to health gains in the pediatric population. This study aimed to estimate the cost-effectiveness of a pediatric tele-resuscitation (Peds-TECH) intervention compared to the usual care in five community hospital emergency departments (EDs). Using a decision tree analysis approach with secondary retrospective data from a 3-year time period, this cost-effectiveness analysis was completed.MethodsA mixed methods quasi-experimental design was embedded in the economic evaluation of Peds-TECH intervention. Patients aged &lt;18 years triaged as Canadian Triage and Acuity Scale 1 or 2 at EDs were eligible to receive the intervention. Qualitative interviews were conducted with parents/caregivers to explore the out-of-pocket (OOP) expenses. Patient-level health resource utilization was extracted from Niagara Health databases. The Peds-TECH budget calculated one-time technology and operational costs per patient. Base-case analyses determined the incremental cost per year of life lost (YLL) averted, and additional sensitivity analysis confirmed the robustness of the results.ResultsOdds ratio for mortality among cases was 0.498 (95% CI: 0.173, 1.43). The average cost of a patient receiving the Peds-TECH intervention was $2,032.73 compared to $317.45 in usual care. In total, 54 patients received the Peds-TECH intervention. Fewer children died in the intervention group resulting in 4.71 YLL. The probabilistic analysis revealed an incremental cost-effectiveness ratio of $64.61 per YLL averted.ConclusionPeds-TECH appears to be a cost-effective intervention for resuscitating infants/children in hospital emergency departments.
Minimization and Prevention of Risks of Reducing the Efficiency of the Clinical Diagnostic Laboratory as a Result of the Implementation of the Requirements of STB ISO 15189-2015 "Identification and Management of Nonconformities": Experience in the Implementation and Use of Electronic Technology for Recording Nonconformities in Clinical Laboratory Practice
Authors: Выдрицкий А.В. , Бородовская В.Н. , Гулякевич А.Г. , Чистякова И.А. , Таврель А.А. , Лавицкая Т.В. 
Published: June 2023

В общем технологическом процессе выполнения лабораторных исследований на различных его этапах могут возникать риски, влияющие на конечный результат. В связи с этим в практике работы лабораторий необходимо использовать систему управления рисками. С целью оценки эффективности процесса управления рисками, реализованного в группе компаний ИНВИТРО, был проведен анализ влияния внедренного процесса на различные показатели деятельности (экономические, технические, временные) компании. На основании результатов проведенного исследования также проведена оценка влияния внедренного процесса управления рисками, регламентированного требованиями ISO 15189, на качество оказываемых лабораторных услуг. Внедрение процесса управления рисками в группе компаний ИНВИТРО позволяет поддерживать качество лабораторных исследований на высоком уровне и реализует требования международного стандарта ISO 15189.
In the general technological process of performing laboratory research at its various stages, risks may arise that affect the final result. In this regard, it is necessary to use a risk management system in the practice of laboratories. In order to evaluate the effectiveness of the risk management process implemented in the INVITRO group of companies, an analysis was made of the impact of the implemented process on various performance indicators (economic, technical, temporary) of the company. Based on the results of the study, an assessment was also made of the impact of the implemented risk management process, regulated by the requirements of ISO 15189, on the quality of laboratory services provided. The implementation of the risk management process in the INVITRO group of companies allows us to maintain the quality of laboratory research at a high level and implements the requirements of the international standard ISO 15189.
Chronic Heart Failure and Cardiorenal Relationships: Clinical and Laboratory Manifestations
Authors: Мацкевич С.А. , Бельская М.И. , Пархомец М.И. 
Published: June 2023

Введение. В последние десятилетия наблюдается явная тенденция к увеличению количества пациентов с коморбидными заболеваниями. Считается, что почки являются одним из органов-мишеней при хронической сердечной недостаточности (ХСН). Но выполненные ранее исследования проводились в основном с участием пациентов с различной коморбидной патологией, и крайне мало работ по изучению дисфункции почек у пациентов с кардиальной патологией при отсутствии почечной патологии. Цель. Изучить кардиоренальные взаимоотношения у пациентов с ХСН и оценить значение маркеров дисфункции почек. Материалы и методы. Обследовано 168 пациентов с наличием клинических признаков ХСН. Проведены лабораторные и клинические исследования. Результаты. Большинство пациентов с ХСН имеют признаки дисфункции почек. В проведенном исследовании определено значение уровней цистатина С, микроальбуминурии и альфа-1-микроглобулина в моче как маркеров ранней почечной дисфункции у пациентов с хронической сердечной недостаточностью. Выводы. Тесты определения цистатина С в крови и моче, альфа-1-микроглобулина мочи и выявление микроальбуминурии могут рассматриваться как биомаркеры ранней стадии формирования дисфункции почек у пациентов с ХСН.
Introduction. In recent decades, there has been a clear trend towards an increasing number of patients with comorbid conditions. It is believed that the kidneys are one of the target organs in chronic heart failure (CHF). However, previous studies were mainly conducted involving patients with various comorbidities, while studies investigating kidney dysfunction in patients with cardiac pathology in the absence of renal pathology are very sparse. Purpose. To study cardiorenal relationships in patients with CHF and to establish the significance of determining markers of kidney dysfunction for predicting the formation of cardiorenal pathology. Materials and methods. 168 patients with clinical signs of CHF were examined. Laboratory and clinical tests were conducted. Results. Most patients with CHF have signs of kidney dysfunction. The study determined the significance of urinary levels of cystatin C, microalbuminuria and alpha-1-microglobulin as markers of early renal dysfunction in patients with chronic heart failure. Conclusions. Tests for the determination of cystatin C in blood and urine, urine alpha-1- microglobulin and the detection of microalbuminuria can be considered as biomarkers of the early stage of kidney dysfunction in patients with CHF.