bluuebunny/crossref_metadata_2025_split huggingface dataset:
Surgical Precision Analysis of Orthognathic Surgery Combined With Invisible Orthodontic
Authors: Yi Jing-rui , Yeweng San-jie , Wu Zhong-xing 
Published: February 2023

Background:
This study aimed to explore the changes in hard tissue after applying invisible orthodontic-orthognathic treatment and the digital design, and to explore the accuracy of the treatment effect of maxillofacial tissue after invisible orthodontic treatment and orthognathic treatment.

Methods:
From September 2020 to January 2022, 25 patients with class III skeletal malocclusion and 7 patients with class II skeletal malocclusion, were treated with invisible orthodontic treatment and orthognathic combined treatment. Orthodontic treatment with preoperative invisible orthodontic treatment followed by orthodontic surgery. All patients had cephalometric lateral films after surgery to analyze orthognathic surgery's goals and surgical effects of orthognathic surgery and the digital design. Measure the angle of the sella-nasion-A point angle, angle of sella-nasion-B point, ANB angle, maxillary convex angle, mandibular plane (MP) angle, 1-SN angle, 1-MP angle, etc, and compare surgery outcome with digital design.

Result:
All patients were satisfied with the effect and no complications occurred. Angle of sella-nasion-A point, angle of sella-nasion-B point, ANB angle, maxillary convex angle, MP angle, 1-SN angle, and 1-MP angle had no significant difference between the postoperative effect and the purpose of digital design (P>0.05), there was no apparent deviation between the upper and lower jaw and the chin (P>0.05).

Conclusion:
The combined invisible orthodontic treatment and orthognathic treatment are accurate and effective, and are worthy of promotion. It supplements traditional orthognathic therapy and is suitable for corresponding patients.
Human FAM111A inhibits vaccinia virus replication by degrading viral DNA-binding protein I3 and is antagonized by poxvirus host range factor SPI-1
Authors: Zhu Junda , Gao Xintao , Zhang Zihui , Deng Yining , Xie Shijie , Ren Shuning , Li Yarui , Li Hua , Niu Kang , Fu Shufang , Li Yinü , Moss Bernard , Wu Wenxue , Peng Chen 
Published: February 2023

AbstractPoxviruses are large double-stranded DNA viruses that infect a wide range of animals including humans. Since the eradication of smallpox, other members of the poxvirus family, such as monkeypox virus (MPXV) are still posing a great threat to public health. Vaccinia virus (VACV) is a prototypic poxvirus used as the vaccine strain for smallpox eradication. VACV encodes a serine protease inhibitor 1 (SPI-1) conserved in all orthopoxviruses, which has been recognized as a host range factor for modified vaccinia virus Ankara (MVA), an approved smallpox vaccine and a promising vaccine vector. FAM111A, a nuclear protein that regulates host DNA replication, was shown to restrict the replication of VACV-ΔSPI-1 in human cells. Nevertheless, the detailed antiviral mechanisms of FAM111A were unresolved. Here, we show that FAM111A is a potent restriction factor for VACV-ΔSPI-1 and MVA. Deletion of FAM111A rescued the replication of MVA and VACV-ΔSPI-1 and overexpression of FAM111A significantly reduced viral DNA replication and virus titers but did not affect viral early gene expression. The antiviral effect of FAM111A necessitated its trypsin-like protease domain and DNA binding domain but not the PCNA-interacting motif. We further discovered that FAM111A translocated into the cytoplasm upon VACV infection and this process was mediated by the cGAS-STING signaling pathway. Infection-triggered FAM111A degraded the nuclear pore complex via its protease activity, translocated to the cytoplasm, and interacted with and promoted the degradation of virus DNA binding protein I3 in a DNA-dependent manner. Interestingly, the protease activity of FAM111A was only needed for nuclear export but not I3 degradation as further analysis showed I3 was degraded through autophagy. Moreover, VACV SPI-1 was found primarily in the nucleus of infected cells and antagonized FAM111A by prohibiting its nuclear export. MPXV and lumpy skin disease virus SPI-1s also inhibited human FAM111A. Our findings reveal the detailed mechanism by which FAM111A functions to restrict a cytoplasmic DNA virus and provide explanations for the immune evasive function of VACV SPI-1.
SingleCellGGM enables gene expression program identification from single-cell transcriptomes and facilitates universal cell label transfer
Authors: Xu Yupu , Wang Yuzhou , Ma Shisong 
Published: February 2023

AbstractGene co-expression analysis of single-cell transcriptomes that aims to define functional relationships between genes is challenging due to excessive dropout values. Here, we developed a single-cell graphical Gaussian model (SingleCellGGM) algorithm to conduct single-cell gene co-expression network analysis. When applied to mouse single-cell datasets, SingleCellGGM constructed networks from which gene co-expression modules with highly significant functional enrichment were identified. We considered the modules to be gene expression programs (GEPs). These GEPs enable direct cell-type annotation of individual cells without cell clustering, and they are enriched with genes required for the functions of the corresponding cells, sometimes at a level greater than 10-fold. The GEPs are conserved across datasets and enable universal cell-type label transfer across different studies. We also proposed a dimension-reduction method through averaging-by-GEPs for single-cell analysis, enhancing the interpretability of results. Thus, SingleCellGGM offers a unique GEP-based perspective to analyze single-cell transcriptomes and reveals biological insights shared by different single-cell datasets.
NLRP1 inflammasome modulates senescence and senescence-associated secretory phenotype
Authors: Muela-Zarzuela Inés , Suarez-Rivero Juan Miguel , Gallardo-Orihuela Andrea , Wan Chun , Izawa Kumi , Gregorio-Procopio Marta de , Coillin Isabelle , Ryffel Bernhard , Kitaura Jiro , Sanz Alberto , Zglinicki Thomas von , Mbalaviele Gabriel , Cordero Mario D. 
Published: February 2023

AbstractSenescence is a cellular aging-related process triggered by different stresses and characterized by the secretion of various inflammatory factors referred to as the senescence-associated secretory phenotype (SASP). Here, we present evidence that the inflammasome sensor, NLRP1, is a key mediator of senescence induced by irradiation both in vitro and in vivo. The NLRP1 inflammasome promotes senescence by regulating the expression of p16, p21, p53, and SASP in Gasdermin D (GSDMD)-dependent manner as these responses are reduced in conditions of NLRP1 insufficiency or GSDMD inhibition. Mechanistically, the NLRP1 inflammasome is activated downstream of the cytosolic DNA sensor cGMP-AMP (cGAMP) synthase (cGAS) in response to genomic damage. These findings provide a rationale for inhibiting the NLRP1 inflammasome-GSDMD axis to treat senescence-driven disorders.
Beyond design and delivery: developing a model to measure end-user satisfaction (delight) in projects
Authors: Abu Arqoub Muath , Ghanbaripour Amir Naser , Langston Craig , Skulmoski Greg 
Published: February 2023

PurposeThis research aims to develop and test a model for measuring end-user satisfaction (EUS) in a practical manner and then statistically verify its reliability and validity.Design/methodology/approachA comprehensive list of attributes using extensive literature review, focus group and brainstorming meetings were used to create a set of attributes for the model. These attributes were then used in a survey among the end-users (N = 687) of seven case studies with different characteristics (type, size and location) to assess the reliability and validity of the model. The statistical methods included reliability tests (Cronbach's alpha), confirmatory factor analysis (CFA) and correlation analysis), canonical discriminant analysis (CDA), item response theory (IRT) and model specification tests.FindingsEUS must be quantified before determining a project's overall performance. The analysis of repeatability and consistency (reliability and validity) performed on case studies (data collected from the end-users) strongly suggests that the EUS model is robust for a range of project types.Originality/valueAlthough many studies have proposed customer satisfaction models in the project success context, research on quantitative measurement tools is scarce. The paper departs from past research and develops and validates a new EUS model independent of project characteristics (while the study's limitations are acknowledged).
Technology readiness and the older citizen’s acceptance of m-health services in India
Authors: Dash Ajitabh , Mohanty Sandeep Kumar 
Published: February 2023

Purpose
The purpose of this study was to create a theoretical model by combining the technology acceptance model (TAM) with the theory of technology readiness (TR) and then empirically test it to identify the key factors influencing older citizens’ intention to adopt and use mobile health (m-health), which has emerged as a tool to facilitate health-care rights for all.

Design/methodology/approach
The convenience sampling method was used to collect data from 465 respondents aged 60 and up from the Delhi-National capital region of India using a questionnaire survey method. The data collected for this study were analyzed using partial least squares structural equation modeling using SmartPLS 3.0.

Findings
The study’s findings indicate that all TR components influence perceived usefulness (PU) and ease of use. The exception is discomfort, which does not affect perceived ease of use (PEOU). Furthermore, PU and PEOU influenced the older citizen’s attitude toward m-health, and attitude influenced their intention to use m-health applications.

Originality/value
To the best of the authors’ knowledge, this is the first study to apply the TAM in combination with TR index to examine the acceptability of m-health consulting by the older citizen in an emerging economy like India.
Barriers to gender equality in STEMM: do leaders have the gender competence for change?
Authors: Cuthbert Denise , Barnacle Robyn , Henry Nicola , Latham Kay , Sidelil Leul Tadesse , Spark Ceridwen 
Published: February 2023

PurposeScience, technology, engineering, mathematics and medicine (STEMM) workplaces worldwide remain stubbornly resistant to gender equality initiatives. Leaders are vital to driving change, but the extent to which their capabilities lead to change remains unknown. This article examines STEMM leaders' gender competence to achieving transformative changes in gender inequality.Design/methodology/approachThis article examines the capability of STEMM leaders to act as change agents through an in-depth, qualitative analysis of perceptions of gender inequality, sexual harassment, sex discrimination and gender bias within their organisations. Findings are analysed using a customised tripartite gender competence schema, comprising commitment, knowledge and method (or know-how).FindingsThe findings suggest that while STEMM leaders may express a commitment to addressing gender inequality, misapprehensions about the nature and scope of the problem are likely to hamper efforts. Two key misapprehensions standout: a tendency to frame gender inequality in primarily numerical terms; and recourse to blaming external factors beyond STEMM for gender inequality in STEMM.Originality/valueThis article makes an original contribution by examining the gender competence of leaders in STEMM organisations, which has not been previously researched. The findings extend understanding of the salience of leaders' capabilities to lead change by identifying key gaps and misapprehensions in STEMM leaders' understanding of the nature and scope of the problem.
How social media use enhances salesperson performance
Authors: Franck Romain , Damperat Maud 
Published: February 2023

Purpose
Based on a relationship marketing approach, this paper aims to study the influence of social media use on salesperson performance and its underlying mechanisms from the perspective of salespeople in B2B settings.

Design/methodology/approach
To test the proposed model, the authors used structural equation modeling with a sample of 196 French B2B salespeople. Moreover, to explore the moderating effect of emotional management between social media use and relationship quality, the authors used the Hayes macro PROCESS for SPSS and the Johnson–Newman’s floodlight method.

Findings
The authors confirm the direct role of social media use on salesperson performance, and its indirect role through the parallel mediation of social proximity and relationship quality. The empirical study provides evidence for the moderating effect of emotional management on the relationship between social media use and relationship quality.

Practical implications
Companies should promote the use of social media to increase both the sales and creative performance of salespeople. Moreover, salespeople with low to moderate abilities to manage other people’s emotions benefit strongly from the use of social media, as this directly increases their relationship with their customers.

Originality/value
The research complements the conceptualization of salesperson performance as a combination of sales performance and sales creativity and shows that emotional management is an asset for social media users to develop valuable business relationships.
City branding in a multi-level governance context: comparing branding performance across five institutional models for urban development in Saudi Arabia
Authors: Alsayel Abdulrhman , Fransen Jan , de Jong Martin 
Published: February 2023

Purpose
The purpose of this study is to examine how five different multi-level governance (MLG) models affect place branding (PB) performance in Saudi Arabia.

Design/methodology/approach
In hierarchical administrative systems, central governments exert control on PB, influencing its effectiveness. While PB as such is widely studied, the effect of MLG on PB performance in centralized administrative systems remains understudied. The study is approached as a multiple case study of nine cities.

Findings
The study reveals that different MLG models indeed affect PB performance differently. Direct access to central leadership and resources boosts branding performance, while privatization promotes flexibility with similarly positive effects. Study findings, furthermore, show that some cities are considered too big to fail. Cities such as Riyadh and Neom are of prime importance and receive plenty of resources and leadership attention, while others are considered peripheral, are under-resourced and branding performance suffers accordingly. Emerging differences in PB performance associated with different MLG models are thus likely to deepen the gap between urban economic winners and losers.

Originality/value
This paper introduces five MLG models based on the actors involved in PB, their interactions and their access to resources. For each model, this paper assesses other factors which may influence the effectiveness of PB as well, such as access to the national leadership and staff capacity. This research thereby adds to the literature by identifying specific factors within MLG models influencing PB performance in hierarchical administrative systems.
Internationalisation, knowledge intensity, adaptive culture and absorptive capacity: a strategic entrepreneurship enabling logic for export firms
Authors: Luu Dung Tien 
Published: February 2023

PurposeThis study proposes a logic to enable strategic entrepreneurship for export firms through absorptive capacity and adaptive culture to capitalise on the knowledge intensity from internationalisation.Design/methodology/approachThe study sample comprises 422 key role employees at 98 export firms in Ho Chi Minh City, Vietnam. The data are analysed using a structural equation model.FindingsThe results reveal that the firm's knowledge intensity may serve as a reservoir, absorbing and reconciling knowledge acquired from internationalisation and redistributing it to strategic entrepreneurship. A firm's absorptive capacity and adaptive culture can act as buffers, allowing internationalisation knowledge to permeate and transfer to administrative bodies and fostering strategic entrepreneurship.Originality/valueThis study proposes an integrated model of the relationship between the degree of internationalisation and strategic entrepreneurship through novel lenses of knowledge-based perspective with the organisational capabilities.
Masuum baby food – a positioning conundrum
Authors: S. Mahadevan , Thanigan Jayanthi , Reddy N. Srinivasa 
Published: February 2023

Research methodology
Primary and secondary data.

Case overview/synopsis
This case is set in the year 1987 when many parts in India were milk deficient. Seasonal and cyclical shortages were more of a norm. There were however early signals that the cooperative dairying model across the country was gaining momentum and the milk production in the country was poised for a sharp upswing.
Masuum baby food is a winning brand in Shalanda Milk Foods portfolio with a top-line revenue of Rs 300m per annum, contributing to 60% of the firm’s revenue and registering a healthy 14% annual growth.
The brand was used as an additive for tea and coffee, a purpose for which it was not intended, apart from it being used as a baby food, which of course was the intended purpose.
The World Health Organisation had proposed a code which among other things proscribed brand advertisement and promotion of baby food with a view to promote mother’s milk for infants.
Though the brand sales seemed to continue to grow, thanks to demand operating above supply, there was a realization that the brand could head into an identity crisis and the fact that it cannot speak for itself could be damning.
The protagonist in the case came up with a strategy to launch a new brand with the same composition as Masuum and in a controlled manner transfer volume from Masuum to new brand. Even while appreciating the protagonist’s recommendation, the Managing Director exhorts him to come up with a stronger rationale for launching a new product and review whether it constitutes a comprehensive solution.

Complexity academic level
This case can be used at the Master’s in business administration level in the Marketing Management course. This case should be scheduled after covering topics on segmentation, targeting, positioning and brand.
This case can also be used to introduce case methodology as it follows the framework of sharply defining a problem, explaining the relationships amongst variables, identifying and evaluating solution choices, and recommending the most effective.
Patterns and determinants of plant‐derived lignin phenols in coastal wetlands: Implications for organic C accumulation
Authors: Xia Shaopan , Song Zhaoliang , Wang Weiqi , Fan Yaran , Guo Laodong , Van Zwieten Lukas , Hartley Iain P. , Fang Yin , Wang Yidong , Zhang Zhenqing , Liu Cong‐Qiang , Wang Hailong 
Published: February 2023

Abstract

As a major plant‐derived soil organic carbon (SOC) component, lignin phenols are unique biomarkers that reflect biogeochemical characteristics under different vegetation compositions and climatic zones in coastal wetlands. However, the latitudinal patterns of plant‐derived lignin phenols to SOC and their link with the stability and controlling mechanisms remain poorly understood.

A total of 156 soil samples from 39 sites along a 5000 km coastal transect, were taken to explore the effects of biological and environmental controls on the patterns of lignin phenols. Lignin phenols had contents ranging from 1.91 to 83.3 mg g−1 OC, and a positive correlation was detected in grass‐dominated salt marsh, but a weakly negative correlation in mangrove. Positive correlations between SOC or lignin content and C/V or S/V (the cinnamyl‐ or syringyl‐to‐vanillyl) ratios were found, while overall negative correlations between SOC or lignin content and (Ad/Al)V or (Ad/Al)S (the acid‐to‐aldehyde of vanillyl or syringyl units) ratios were detected, respectively, which confirmed the validity of these lignin biomarker degradation parameters.

Our findings revealed that plant C inputs and monomer ratios directly influenced the capacity of lignin phenols in soils. Lignin content and stabilization was mainly controlled by soil properties (i.e. pH, EC sand/clay). Mean annual temperature (MAT) influenced the patterns of lignin phenols both directly by increasing decomposition and indirectly by changing the vegetation and soil biogeochemistry (i.e. microbial substrate availability).

Coastal wetlands are characterized by high primary productivity and C burial rate, yet plant‐derived lignin phenols are not as much as we thought compared to microbial residues C. Precise identification and quantification of the origin, decomposition, and determinants of lignin phenols help us understand their contribution to C sequestration and its response to climate and environmental changes.

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Differential effect of climate of origin and cultivation climate on structural and biochemical plant traits
Authors: Thakur Dinesh , Hadincová Věroslava , Schnablová Renáta , Synková Helena , Haisel Daniel , Wilhelmová Nada , Dostálek Tomáš , Münzbergová Zuzana 
Published: February 2023

Abstract

Exploring patterns and causes of intraspecific trait variation is crucial for a better understanding of the effects of climate change on plant populations and ecosystems. However, our current understanding of the intraspecific trait variation is mainly based on structural (morphological) traits, and we have limited knowledge on patterns and causes of variation in biochemical traits (e.g. leaf pigments), which are also crucial for plant adaptation. As a result, we also do not know how similar the climatic effects on structural versus biochemical traits are.

Using plant traits from 110 genotypes representing 11 Festuca rubra populations grown in 4 different climates, we studied trait covariation among structural traits (linked to fitness, resource use, gas exchange and reproduction) and biochemical traits (linked to photosynthesis, photoprotection and oxidative stress). We also disentangled the relative role of the climate of origin and the climate of cultivation in the structural versus biochemical traits and tested for adaptive plasticity in the traits.

We found that (1) biochemical traits did not covary with structural traits and represent independent ‘photoharvesting–photoprotection’ strategy dimension of functional variation; (2) interactive effects of climate of origin and cultivation were more pronounced for biochemical than structural traits. (3) Trait plasticity was affected by the climate of origin (precipitation and temperature as well as their interaction); (4) F. rubra showed both adaptive and maladaptive plasticity, and adaptiveness depended upon trait type, cultivation climate and climate of origin.

Overall, our results suggest that structural and biochemical plant traits respond differentially to climate and thus the response of one group of traits cannot be predicted from the other. Responses are also strongly determined by interactions between the climate of origin and cultivation. Thus, more studies on variation in biochemical traits, their correspondence to other traits, and their variation with climate are needed.

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