bluuebunny/crossref_metadata_2025_split huggingface dataset:
Does the Use of Negative Pressure Wound Therapy and Postoperative Drains Impact the Development of Surgical Site Infections?
Authors: LiBrizzi Christa L. , Sabharwal Samir , Forsberg Jonathan A. , Leddy Lee , Doung Yee-Cheen , Morris Carol D. , Levin Adam S. ,   on behalf of the PARITY Investigators
Published: July 2023

Background:
Surgical site infections (SSIs) represent a major complication following oncologic reconstructions. Our objectives were (1) to assess whether the use of postoperative drains and/or negative pressure wound therapy (NPWT) were associated with SSIs following lower-extremity oncologic reconstruction and (2) to identify factors associated with the duration of postoperative drains and with the duration of NPWT.

Methods:
This is a secondary analysis of the Prophylactic Antibiotic Regimens in Tumor Surgery (PARITY) trial, a multi-institution randomized controlled trial of lower-extremity oncologic reconstructions. Data were recorded regarding the use of drains alone, NPWT alone, or both NPWT and drains, including the total duration of each postoperatively. We analyzed postoperative drain duration and associations with tourniquet use, intraoperative thromboprophylaxis or antifibrinolytic use, incision length, resection length, and total operative time, through use of a linear regression model. A Cox proportional hazards model was used to evaluate the independent predictors of SSI.

Results:
Overall, 604 patients were included and the incidence of SSI was 15.9%. Postoperative drains alone were used in 409 patients (67.7%), NPWT alone was used in 15 patients (2.5%), and both postoperative drains and NPWT were used in 68 patients (11.3%). The median (and interquartile range [IQR]) duration of drains and of NPWT was 3 days (IQR, 2 to 5 days) and 6 days (IQR, 4 to 8 days), respectively. The use of postoperative drains alone, NPWT alone, or both drains and NPWT was not associated with SSI (p = 0.14). Increased postoperative drain duration was associated with longer operative times and no intraoperative tourniquet use, as shown on linear regression analysis (p < 0.001 and p = 0.03, respectively). A postoperative drain duration of ≥14 days (hazard ratio [HR], 3.6; 95% confidence interval [CI], 1.3 to 9.6; p = 0.01) and an operative time of ≥8 hours (HR, 4.5; 95% CI, 1.7 to 11.9; p = 0.002) were independent predictors of SSI following lower-extremity oncologic reconstruction.

Conclusions:
A postoperative drain duration of ≥14 days and an operative time of ≥8 hours were independent predictors of SSI following lower-extremity oncologic reconstruction. Neither the use of postoperative drains nor the use of NPWT was a predictor of SSI. Future research is required to delineate the association of the combined use of postoperative drains and NPWT with SSI.

Level of Evidence:
Therapeutic Level II. See Instructions for Authors for a complete description of levels of evidence.
Long-term monitoring of fatty acid oxidation defects - Results from a MetabERN survey
Authors: Schwantje Marit , Grünert Sarah C. , Fuchs Sabine A. 
Published: July 2023

Abstract
Background Implementation of long-chain fatty acid oxidation defects (lcFAOD) in newborn screening (NBS) programs allows for pre-symptomatic diagnosis and treatment. The long-term natural history of NBS lcFAOD patients is largely unknown and may differ from clinically diagnosed pre-NBS patients. This complicates long-term monitoring of lcFAOD and may cause high monitoring variability. To gain insight in current clinical practice, we performed a web-based questionnaire among all metabolic members of the European Reference Network for Hereditary Metabolic Disorders (MetabERN).Results Thirty-seven colleagues representing at least 35 European metabolic centres shared their experience and results were discussed at the European Metabolic Group (EMG) meeting 2022. The centres concurred in many aspects of long-term monitoring of lcFAOD including the frequency of clinical visits, determination of laboratory parameters, cardiac monitoring and retinopathy screening. Main discrepancies comprised hepatic imaging, glucose monitoring and electrophysiological investigations.Conclusions Discrepancies may reflect differences in local availability of monitoring tools, the inclusion of lcFAOD in NBS programs as well as differences in local genotypes and phenotypes. Because monitoring strategies are largely based on the natural disease course of clinically identified patients, there might be over-monitoring of some NBS patients. Nevertheless, we advocate long-term monitoring because resulting information is essential to further characterize the natural disease course, develop evidence-based guidelines and provide a basis for evaluation of future therapies.
Alginate-zein composite modified with metal organic framework for sulfasalazine delivery
Authors: Asadollahi Tannaz , Motakef-Kazemi Negar , Hallajian Sara 
Published: July 2023

Abstract
Metal-organic frameworks (MOFs) have promising prospects as drug nanocarrier, but are more limited in biomedical applications due to their poor stability and biocompatibility. To address this issue, sodium alginate-zein (MOF/SA-ZN) nanocomposites modified metal-organic framework was developed and used as an effective nanocarrier for sulfasalazine (SSZ) delivery. The obtained nanocomposite was structurally and morphologically characterized using different physicochemical techniques including Fourier transform infrared (FTIR), X-ray diffraction (XRD), and Field emission scanning electron microscopy (FESEM). Based on the results, the Zn2(BDC)2(DABCO) MOF were dispersed in biopolymers. The proposed nanocarrier leads to increased drug encapsulation and reduced side effects of SSZ, thus improving its bioavailability. In addition, the antibacterial properties of samples have been studied against Staphylococcus aureus and Pseudomonas aeruginosa. The results showed that the drug-loaded Zn-MOF/SA-ZN has a higher antibacterial activity against Staphylococcus aureus gram positive bacteria compared to SSZ. The current research provides a promising insight into the fabrication of polymer modified MOF based drug delivery platforms and antibacterial agents.
A Retrospective Study of the Clinical Outcomes of Pilon Variant Posterior Malleolar Fracture involving Intra-Articular Impacted Fragments
Authors: You Mengzhen , Chen Cheng , Sun Yihao , Sun Xiaoting , Gao Yun , Wang Lei 
Published: July 2023

Abstract
INTRODUCTION
Intra-articular impacted fragment (IAIF) is commonly found in the Pilon variant posterior malleolar (PVPM) fracture. Poor quality of reduction may result in articular incongruity, leading to ankle function impairment and ultimately traumatic arthritis. However, the debating remains on if the IAIF must be reduced, and how the presence or malreduction of the IAIF influences the prognosis in PVPM fractures. This retrospective study is to evaluate the prognostic effect of the IAIF reduction in the PVPM fractures.
METHODS
We studied 22 patients with PVPM fractures admitted to our hospital between June 2020 and June 2021, who were treated with open surgery and followed-up for 12 months retrospectively. The patients were divided into two groups: six patients without IAIF (No-IAIF group) and 16 patients with IAIF (IAIF group). Burwell-Charnley scoring system and ankle CT scan were used to evaluate the radiographic outcomes. At postoperative 12 months, American Orthopedic Foot and Ankle Score (AOFAS) was set as primary outcome. Visual Analog Scale (VAS) pain score, the Medical Outcomes Study 36-Item Short-Form Health Survey (SF-36) were secondary outcomes and associated complications were recorded. Postoperative articular stepping ≥2mm or articular incongruity on the sagittal view of CT scans was considered “poor” reduction, otherwise “anatomical”. The study abided by the Declaration of Helsinki and is approved by Human Ethics Committee of our hospital. All persons gave their informed consent prior to their inclusion in the study.
RESULTS
The articular surface of five of six patients in No-IAIF group and eight of 16 patients in IAIF group were considered “anatomically” reduced. Statistical difference of AOFAS, SF-36 and VAS was found significant between the No-IAIF and IAIF groups at postoperative 12 months. In the fractures considered with “anatomical” reduction, significant difference was only seen in SF-36 between the patients with and without IAIF. Three of 22 patients received syndesmotic fixations. No difference of associated complications was noted.
DISCUSSION
The results of this study indicated that the short-term clinical effect was dependent of the presence the IAIF. Importantly, the reduction satisfactory was statistically associated with improved clinical outcomes at 12 months postoperatively.
SIGNIFICANCE
The presence of the IAIF negatively affect the clinical outcome and the anatomical reduction of the articular congruity will positively affect the prognosis of PVPM fracture.
Resilient water infrastructure partnerships in institutionally complex systems face challenging supply and financial risk tradeoffs
Authors: Hamilton Andrew , Reed Patrick , Gupta Rohini , Zeff Harrison , Characklis Gregory 
Published: July 2023

Abstract

As regions around the world invest billions in new infrastructure to overcome increasing water scarcity, better guidance is needed to facilitate cooperative planning and investment in institutionally complex and interconnected water supply systems. This work combines detailed water resource system ensemble modeling with multiobjective intelligent search to explore highly uncertain infrastructure investment partnership design tradeoffs in the context of ongoing canal rehabilitation and groundwater banking in California. We highlight that severe tradeoffs can emerge between conflicting goals related to water supply deliveries, partnership size, and the underlying financial risks associated with cooperative infrastructure investments. We demonstrate how hydroclimatic variability and institutional complexity create significant uncertainty in realized water supply benefits and the potential for strong heterogeneity in partners’ financial risks that threaten infrastructure investment partnership viability. Importantly, the partnerships discovered by our multiobjective intelligent search framework are found to deliver substantially higher water supply benefits with a fraction of the financial risk compared to status quo planning processes. This work has important implications globally for efforts to use cooperative infrastructure investments to enhance the resilience and financial stability of water supply systems confronting increasing competition for scarce resources.
Papillary thyroid carcinoma coexisting with benign thyroid and parathyroid pathology: clinical and pathomorphological features
Authors: Dinets A. , Gorobeiko M. , Hoperia V. , Lovin A. , Tarasenko S. 
Published: July 2023

Background. Papillary thyroid carcinoma (PTC) is the most frequent malignant neoplasm originating from follicular cells of thyroid gland. PTC is often coexisting with other benign thyroid pathology such as chronic lymphocytic thyroiditis, follicular thyroid adenoma, toxic thyroid adenoma, Graves’ disease, non-toxic multinodular goiter. PTC can be diagnosed in patients undergoing surgical treatment for hyperparathyroidism. However, the clinical and pathomorphological features of PTC in the presence of other benign thyroid or parathyroid pathology, as well as possible differences in surgical tactics, remain relevant as evidenced by previously published reports. The purpose of the study is to assess the prevalence and determine the differences in the clinical and pathomorphological parameters of PTC in the presence of benign thyroid and parathyroid pathology. Materials and methods. There were identified 91 patients with PTC, who underwent surgical treatment at the clinical bases of the Department of Surgery of the NSC “Institute of Biology and Medicine” of Taras Shevchenko National University of Kyiv. Results. In the studied PTC cohort, 31 (35 %) patients were without coexisted benign thyroid pathology and 60 (35 %) patients had it (PTC/coexisted). A statistically significantly higher number of mitoses per 10 high power fields in the PTC group were identified in 3 (10 %) patients, as compared to the absence of this pathohistological parameter in the PTC/coexisted (p = 0.037). Further analysis of these 3 cases showed that 4 mitotic figures were found in one PTC, and one mitotic figure in the other two cases per 10 high power fields (400×). Conclusions. Papillary thyroid carcinoma in patients with other benign thyroid pathology is associated with lower biological aggressiveness than PTC without comorbidity as evidenced by a lower frequency of mitotic figures per 10 high power fields. The presence of concomitant benign thyroid pathology can be considered as a favorable prognostic factor for patients with PTC.
Phenolic Profile and Antioxidant Potential of Aqueous Extracts of Selected Traditional Anti-cough Plants
Authors: Osuagwu Olachi Lilian , Igwe Chidi Uzoma , Nzebude Chiamaka Perpetua , Njoku Onyinyechi Chijioke , Ejiofor Juliet Chioma 
Published: July 2023

The recent surge in attention towards plant-based antioxidants can be attributed to their perceived advantageous impact on human health. The present study assessed the phenolic profile, antioxidant potential, and free radical scavenging ability of hot aqueous leaf extracts obtained from Vernonia amygdalina, Piper guineense, and Gongronema latifolium. High-Performance Liquid Chromatography (HPLC) was used to examine phenolic profile. Antioxidant capacity was conducted using total flavonoid content (TFC), total phenol content (TPC), total antioxidant capacity (TAC), polyphenol oxidase (PPO) activity, while ferric reducing antioxidant potential (FRAP), nitric oxide (NO), hydroxyl (OH), and 2, 2-diphenyl-2-picrylhydrazyl (DPPH) were analysed for their radicals scavenging activities. G. latifolium displayed notable phenolic compounds, such as lunamarin (76.32mg/ml), ribalinidine (64.08 mg/ml), gallocatechin (48.58mg/ml), aglycone (41.69 mg/ml), flavonone (33.45mg/ml), and flavan-3-ol (30.49mg/ml). The plant extracts contained resveratol, kaempferol, and ribalinidine in a consistent manner across all samples. The findings suggest that the plants exhibits noteworthy antioxidant potential, with G. latifolium displaying the highest antioxidant capacity (96.18 ± 0.11µg/mL) and total phenolic content (28.50 ± 0.04 µg/mL). V. amgydalina showed highest polyphenol oxidase activity, at 7.14 ± 0.10 µg/mL G. latifolium as well showed high •NO scavenging radicals and FRAP activity, while exhibiting the least efficacy in •OH scavenging radicals. The results indicate that all three samples demonstrated a noteworthy increase in DPPH scavenging activity, which was statistically significant at p<0.05 compared to standard. Results reveals that plant extracts showed significant phenolic compounds, antioxidant and free radicals property. These observations provides a rationale for the traditional use of these extracts in folk medicine for management and treatment of cough.
Keywords. Gongronema latifoluim, Veronia amygdalina, Piper guineense, Phenolic profile, Antioxidant capacity, Free Radical, cough.
Exploring Drug Prescription Patterns in the Neurology Department of a Tertiary Care Hospital: A Comprehensive Analysis
Authors: Nithya R , Neesha Solanky K , Narmadha UDHAYAKUMAR , Redlin R. R. , Ramya A , Manisha B 
Published: July 2023

Objective: Neurological disorders are a major cause of morbidity, mortality and disability. These adversely affect the quality of life among all age group patients. Majority of neurological disorders include Epilepsy, Headache, Cerebrovascular disorders with hemiparesis, Neuropathic pain, Extrapyramidal syndrome, Cervical myelopathy and Parkinson’s disease. This study was done with aim to evaluate the prescription pattern of various drugs in different types of neurological disorders and to use the WHO / INRUD prescribing indicators to assess the rational drug prescribing.
Materials and Methods: A Prescription-based, Observational prospective study was carried out in a tertiary care hospital at South India. The prescription data of patients attending the neurology outpatient department was analysed over a period of 2 months. Rational use of drugs was analysed by the INRUD Scale.
Results: Out of these, 166 patients were male, whereas 134 patients were female. Most prevalent neurological disorders were Trigeminal neuralgia (25.66%), 9.97% of the patient population received injections, with 4% receiving Inj. Dexamethasone 8mg. Overall drug prescribing performance scoring was 3.55.
Conclusion: Our study revealed good Prescribing pattern as shown by WHO scale- IRUD/INRUD. Further such studies with large sample size are needed so as to guide clinicians toward rationale drug.
Keywords: Neurological; International Network of Rational Use of Drugs; Drug Utilisation, Rational Use.
Wydajność pracy jako jeden z elementów decydujących o międzynarodowej konkurencyjności polskiego przemysłu spożywczego
Authors: Mroczek Robert , Tereszczuk Mirosława 
Published: July 2023

W artykule pokazano zmiany wydajności pracy, jakie nastąpiły w minionej dekadzie, tj. w latach 2000-2010, w polskim przemyśle spożywczym i jego poszczególnych branżach, mierzonej wartością produkcji sprzedanej na zatrudnionego. Poprawa wydajności pracy była zjawiskiem powszechnym i dotyczyła wszystkich branż przemysłu spożywczego, aczkolwiek tempo tych zmian było różne. Tempo wzrostu wydajności pracy w polskim przemyśle spożywczym należało do jednego z najwyższych wśród krajów Wspólnoty, zwłaszcza w odniesieniu do krajów najbardziej rozwiniętych, tj. UE-15. Oznacza to, że sukcesywnie zmniejszamy dzielący nas dystans w tym obszarze, a tym samym stajemy się bardziej konkurencyjni. Jest to o tyle ważne, że tracimy inne przewagi komparatywne w postaci m.in. niższych cen surowców rolnych czy mediów, np. prądu, wody.
Outdoor Sports and Environmental Protection in Mountainous Areas Under Ecological Civilisation
Authors: Lu Zhihai 
Published: July 2023

Abstract
Since the mid and late 19th century, people have paid more and more attention to the ecological environment, and environmental awareness and behaviour have been gradually strengthened. The global environmental protection movement is rising daily, and environmental protection will become the focus of human attention in the 21st century. Accelerate the establishment and improvement of the system and mechanism of land and space development, resource conservation and utilisation, and ecological preservation of the environment in the system of ecological civilisation, and promote the formation of a new pattern of harmonious development between man and nature and modernisation. Although China has formulated policies and regulations on environmental protection in outdoor sports development, environmental protection is grim due to problems such as insufficient government supervision, weak public awareness of environmental protection, and relatively backward environmental protection concepts and management methods. During the visit, outdoor sports lovers and club leaders were interviewed. In this context, with the continuous development of outdoor mountain sports driven by the improvement of people’s pursuit of life, there began to be contradictions between outdoor mountain sports and the ecological preservation of the environment, which also became the cause of the author’s concern and research.
One Belt and One Road Impact on Environment, Economy & Health in Western China Through Industry Transfer
Authors: Wang Kai , Wang Ao 
Published: July 2023

Abstract
Based on fully absorbing and learning from the relevant research results at home and abroad, this paper focuses on four aspects: the transfer of polluting industries in the central and western regions and residents’ health problems. Firstly, the current pattern and development trend of regional pollution transfer in China; secondly, the economic effect of the transfer of polluting industries on the western undertaking areas; finally, from the micro and macro perspectives, the paper investigates the impact of the transfer of polluting industries on the individual health and health expenditure of residents in western China. The results show that the gap between industrial environmental and economic efficiency in the western region narrowed and gradually stabilised from 2008 to 2017. However, the gap between industrial environmental efficiency and economic efficiency in the western region widened from 2017 to 2020. The impact of environmental pollution on industrial environmental efficiency in the western provinces and regions has regional differences. Secondly, the present situation and trend of pollution control in western China are macroscopically investigated by comparing the output of general industrial solid waste and the investment in pollution control in different regions. Finally, this paper reveals the impact of the transfer of polluting industries on the health of residents in western China. Based on the characteristics of household category, age, and income of interviewees, the income growth effect of the transfer of polluting industries is less than the health loss caused by the transfer of pollution. It can be found that the transfer of polluting industries has a significant impact on the environment, economy, and the health of residents in western China.
Financial Development and Environmental Pollution Control - An Analysis of Intermediary Effect Based on Technological Innovation
Authors: Han Li , Li Ting 
Published: July 2023

Abstract
Based on the rapid development of green finance and the panel data of 30 provinces in China (excluding Tibet, Taiwan, Hong Kong and Macao) from 2007 to 2020, to deeply discuss the relationship between financial development (FD), technological innovation and environmental pollution (EP) control is the centre of this article by using panel fixed-effect and intermediary effect model. The influence of FD on EP is tested by building a benchmark regression model. In addition, the intermediary effect model is adopted to explore how FD affects EP control through technological innovation mechanism. The conclusions show that China’s FD can effectively promote regional EP control on the whole, and FD can improve EP through technological innovation mechanism, but there is significant regional heterogeneity: compared with high government intervention areas, FD can promote EP control through technological innovation in low government intervention areas. Therefore, it is suggested that all regions promote the construction of financial infrastructure, upgrade the level of regional financial marketisation, speed up the realisation of regional technological innovation and EP control. This work is conducive to the formulation of appropriate government policies to promote the improvement of the financial system and the establishment of innovative mechanisms, and the reasonable reduction of government intervention and the improvement of the efficiency of financial resource allocation based on the needs of financial market players.
New data on the parasitization of Aleurothrixus floccosus (Maskell) (Hemiptera: Aleyrodidae) in Greece
Authors: Stathas G.J. , Kavallieratos N.G. , Cheliotis L.N. , Skouras P.J. , Giakoumaki M.V. , Milonas P.G. 
Published: July 2023

Summary

Signiphora flavella (Girault) (Hymenoptera: Signiphoridae) was recorded in 2022 as a new parasitoid species of the serious pest of citrus Aleurothrixus floccosus (Maskell) in Greece, in two different areas, i.e., the provinces of Laconia and Messinia. Previously, Signiphora flavella was recorded in Greece parasitizing Hemiberlesia rapax (Comstock) and H. lataniae (Signoret) in early 60s. It is mainly a parasitoid species of scale insects belonging to Diaspididae (Hemiptera: Coccomorpha), whiteflies, or a hyperparasitoid of aphelinids.