bluuebunny/crossref_metadata_2025_split huggingface dataset:
The improvement of guava (Psidium guajava) juice quality using crude multi‐enzymatic extracts obtained from yeasts
Authors: Santana Mona Liza , Tavares Iasnaia Maria de Carvalho , Costa Floriatan Santos , Teshima Elisa , de Sena Amanda Reges , Franco Marcelo , de Assis Sandra Aparecida 
Published: December 2022

AbstractGuava juice is cloudy and viscous, which hinders filtration, decreases yield, and causes the loss of quality after its processing and during storage. This study aimed to evaluate enzymatic treatment effects using crude multi‐enzymatic extracts (CME) obtained from Rhodotorula mucilaginosa, Rhodotorula orizycola, and Pseudozyma sp. produced by submerse fermentation in the extraction of juice guava. Mixtures of 100 ml of guava pulp and multi‐enzymatic extracts proposed by Doehlert planning were incubated under constant agitation at 150 rpm and 50°C, and a Doehlert design was applied as a multivariate optimization strategy. The optimal conditions using the multi‐enzymatic extract were: 0.4% (v/v) of CME for 131 min for the multi‐enzymatic treatment using Pseudozyma sp.; 3.0% (v/v) of CME for 154 min using the R. mucilaginosa CME; and 5.0% (v/v) of CME for 90 min using R. oryzicola. The maximum viscosity reduction values for the juices treated with the CME of yeasts were 10.33%, 86.38%, and 13.33% for the juices treated with the CME of Pseudozyma sp., R. mucilaginosa, and R. orizycola, respectively. The physical–chemical properties were improved after treatment with CMEs, yielding a reduction of clarity, increase of total soluble solids and reducing sugars, and decreasing the acidity (pH) for all treatments with enzymatic extracts of all strains. The yeasts studied showed a potential for CME production to be applied to juice, improving the quality of the juice, and R. mucilaginosa was the most prominent yeast due to most significant reduction of viscosity in guava juice.
Comparability of multi‐temporal DTMs derived from different LiDAR platforms: Error sources and uncertainties in the application of geomorphic impact studies
Authors: Kamp Nicole , Krenn Paul , Avian Michael , Sass Oliver 
Published: December 2022

AbstractMulti‐temporal digital terrain models (DTMs) derived from airborne or uncrewed aerial vehicle (UAV)‐borne light detection and ranging (LiDAR) platforms are frequently used tools in geomorphic impact studies. Accurate estimation of mobilized sediments from multi‐temporal DTMs is indispensable for hazard assessment. To study volumetric changes in alpine environments it is crucial to identify and discuss different kind of error sources in multi‐temporal data. We subdivided errors into those caused by data acquisition, data processing, and spatial properties of the terrain. In terms of the quantification of surface changes, the propagation of errors can lead to high uncertainties.Three alpine catchments with different LiDAR point clouds of different origins (airborne laser scanning [ALS], UAV‐borne laser scanning [ULS]), varying point densities, accuracies and qualities were analysed, and used as basis for interpolating DTMs. The workflow was developed in the Schöttlbach area in Styria and later applied to further catchments in Austria. The main aim of the presented work is a comprehensive DTM uncertainty analysis specially designed for geomorphic impact studies, with a resulting uncertainty analysis serving as input for a change detection tool. Our findings reveal that geomorphic impact studies need the careful distinction between actual surface changes and different data uncertainties. ULS combines the benefits of terrestrial laser scanning with all the benefits of ALS. However, the use of ULS data does not necessarily improve the results of the analysis since the high level of detail is not always helpful in geomorphic impact studies. In order to make the different point clouds and DTMs comparable the quality of the ULS point cloud had to be reduced to fit the accuracy of the reference data (older ALS point clouds). Using a point cloud with a high point density with a regular planimetric point spacing and less data gaps, in the best case collected during leaf‐off conditions (e.g., cross‐flight strategy) turned out to be sufficient for our geomorphic research purposes.
Evidence‐based prescription of corticosteroids for COVID‐19 patients: A comparison between general medicine and other specialty in Japan
Authors: Sakaguchi Kota , Watari Takashi , Tokuda Yasuharu 
Published: December 2022

AbstractBackgroundThe difference of evidence‐based prescription for COVID‐19 patients between general medicine and other specialty in Japan is unclear.MethodsA retrospective observational study using a hospital‐based administrative database was conducted for the differences between departments for prescriptions of glucocorticoids in COVID‐19 patients.ResultsOf 65,156 patients, 23,348 met indication for glucocorticoids. General medicine physicians in Japan were more likely to prescribe corticosteroids for COVID‐19 patients than other departments after its evidence was published (adjusted odds ratio, 1.32; p < 0.001; 95% confidence interval, 1.11–1.56).ConclusionsGeneral medicine physicians were more likely to practice evidence‐based care for COVID‐19 patients.
Antimicrobial‐impregnated bone cement use in Australian hospitals: scoping pharmacist awareness and involvement in management
Authors: Teoh Alice Pei Kheng , Hillock Nadine 
Published: December 2022

AbstractBackgroundAntibiotic‐impregnated bone cement (AIBC) is frequently used in arthroplasty surgery to minimise the risk of infection in the prosthetic knee or hip joint.AimTo gain greater insight into the use, documentation, and stock‐management of AIBC in Australian hospitals.MethodA mixed‐methods study was conducted. Antimicrobial surveillance data were analysed to identify Australian hospitals including AIBC in their monthly pharmacy data submissions. An online survey was distributed to pharmacists registered with the National Antimicrobial Utilisation Surveillance Program to investigate knowledge of the use, documentation, and stock‐management of bone cement.ResultsSurveillance data from January to June 2021 showed 13% (n = 28) of the 222 participating hospitals included bone cement in their antimicrobial usage data. All reported AIBC usage data contained an aminoglycoside antibiotic. Fifty‐two pharmacists responded (17% response rate) to the online survey. When asked about inventory, 35% of participants stated that their hospital pharmacies manage bone cements. Of 82 responses, 6% (n = 5) had knowledge of additional antibiotics or antifungals loaded into bone cements intraoperatively. More than half of the respondents reported that documentation of AIBC use was unclear, while others knew to search for it in prosthesis or theatre notes.ConclusionThis study has illustrated a gap in pharmacists' knowledge in the perioperative setting regarding the use and documentation of bone cement, and highlights a possible focus for future education to assist with antimicrobial stewardship in this setting. Consistency in the management and documentation of AIBC would assist in surveillance of usage, help identify variations in practice and provide opportunities for quality improvement.
More reliable graphs are not always stronger
Authors: Graves Christina 
Published: December 2022

AbstractA graph is stronger than a graph if has at least as many connected spanning subgraphs of size as for any positive integer . Counting the number of connected spanning subgraphs of fixed size allows us to compute the reliability of a graph. Formally, the reliability polynomial of a graph is the probability that the graph is connected when each edge is deleted independently with the same fixed probability. A graph is uniformly more reliable than if its reliability polynomial is greater than or equal to the reliability polynomial of for all probabilities. As a direct consequence of the definition, a sufficient condition for to be uniformly more reliable than is for to be stronger than . In this paper, we show that the sufficient condition is not necessary by providing an example of two infinite families of graphs, and , such that is uniformly more reliable than but is not stronger than .
A Tolerance‐Enhanced Spontaneous Parametric Downconversion Source of Bright Entangled Photons
Authors: Singh Sandeep , Kumar Vimlesh , Ghosh Anirban , Forbes Andrew , Samanta G. K. 
Published: December 2022

AbstractSpontaneous parametric down‐conversion (SPDC), a primary resource of photonic quantum entangled states, strongly depends on the intrinsic phase matching condition. This makes it susceptible to changes in factors such as the pump wavelength, crystal temperature, and crystal axes orientation. Such intolerance to changing environmental factors prohibits deployment of SPDC‐based sources in non‐ideal environments outside controlled laboratories. Here, a novel system architecture based on a hybrid linear and non‐linear solution that is shown to make the source tolerance‐enhanced without sacrificing brightness. This linear solution is a lens‐axicon pair, judiciously placed, which is tested together with two common non‐linear crystals, quasi‐phase‐matched periodically‐poled KTiOPO4, and birefringent‐phase‐matched BiB3O6. This approach has the benefit of simultaneous tolerance to the environment and high brightness, which is demonstrated by using the proposed architecture as a stable entangled photon source and a spectral brightness as high as 22.58 ± 0.15 kHz mW−1 with a state fidelity of 0.95 , yet requiring a crystal temperature stability of only ±0.8 °C, a 5 × enhanced tolerance as compared to the conventional high brightness SPDC configurations is reported. This solution offers a new approach to deployable high‐brightness quantum sources that are robust to their environment, for instance, in satellite‐based quantum applications.
A trust‐based resilient consensus algorithm for distributed optimization considering node and edge attacks
Authors: Xu Chentao , Liu Qingshan 
Published: December 2022

SummaryDistributed optimization algorithms have various advantages and wide applications, while the distributed nature also makes them flimsy in the face of external attacks. In this paper two Byzantine attack models are designed, in which the edge attack model is seldom considered before. A resilient distributed consensus algorithm based on the trusted nodes and edges is proposed to defend against the two attack models. The agreement and optimality of the proposed consensus algorithm are guaranteed with theoretical analysis. The simulation results and comparison experiments verify the proposed algorithm to be more effective than the compared one. In the perspective of attackers, which attack model is more recommended is also analysed based on the experiments.
Versatile Janus Architecture for Electrocatalytic Applications
Authors: Sui Nicole L. D. , Lee Jong‐Min 
Published: December 2022

AbstractJanus architectures have garnered great research efforts in recent years, leading to outstanding advances in electrocatalysis. Benefiting from the synergistic combination of their anisotropy which endows the manifestation of various co‐existing electrochemical properties, and their compartmentalized structure that enables each functional domain to retain its inherent activity, with little to no interference from other domains, Janus architectures show great potential as exceptionally versatile electrocatalysts to complement a plethora of electrocatalytic processes. Thus, coupled with the growing interest in Janus architectures for electrocatalysis, it is imperative to investigate and reconsider their design strategies and future directions.
Measurement of the cross-section ratio σψ(2S)/σJ/ψ(1S) in exclusive photoproduction at HERA
Authors:   The ZEUS collaboration, Abt I. , Adamus M. , Aggarwal R. , Aushev V. , Behnke O. , Bertolin A. , Bloch I. , Brock I. , Brook N. H. , Brugnera R. , Bruni A. , Bussey P. J. , Caldwell A. , Catterall C. D. , Chwastowski J. , Ciborowski J. , Ciesielski R. , Cooper-Sarkar A. M. , Corradi M. , Dementiev R. K. , Dusini S. , Ferrando J. , Foster B. , Gallo E. , Gangadharan D. , Garfagnini A. , Geiser A. , Grzelak G. , Gwenlan C. , Hochman D. , Jomhari N. Z. , Kadenko I. , Karshon U. , Kaur P. , Klanner R. , Klein U. , Korzhavina I. A. , Kovalchuk N. , Kuze M. , Levchenko B. B. , Levy A. , Löhr B. , Lohrmann E. , Longhin A. , Lorkowski F. , Makarenko I. , Malka J. , Masciocchi S. , Nagano K. , Nam J. D. , Onishchuk Yu. , Paul E. , Pidhurskyi I. , Polini A. , Przybycień M. , Quintero A. , Rubinsky I. , Ruspa M. , Schneekloth U. , Schörner-Sadenius T. , Selyuzhenkov I. , Shchedrolosiev M. , Shcheglova L. M. , Skillicorn I. O. , Słomiński W. , Solano A. , Stanco L. , Stefaniuk N. , Surrow B. , Tokushuku K. , Tomaszewska J. , Trofymov A. , Turkot O. , Tymieniecka T. , Verbytskyi A. , Wan Abdullah W. A. T. , Wichmann K. , Wing M. , Yamada S. , Yamazaki Y. , Żarnecki A. F. , Zenaiev O. 
Published: December 2022

Abstract
The exclusive photoproduction reactions γp → J/ψ(1S)p and γp → ψ(2S)p have been measured at an ep centre-of-mass energy of 318 GeV with the ZEUS detector at HERA using an integrated luminosity of 373 pb−1. The measurement was made in the kinematic range 30 < W < 180 GeV, Q2< 1 GeV2 and |t| < 1 GeV2, where W is the photon-proton centre-of-mass energy, Q2 is the photon virtuality and t is the squared four-momentum transfer at the proton vertex. The decay channels used were J/ψ(1S) → μ+μ−, ψ(2S) → μ+μ− and ψ(2S) → J/ψ(1S)π+π− with subsequent decay J/ψ(1S) → μ+μ−. The ratio of the production cross sections, R = σψ(2S)/σJ/ψ(1S), has been measured as a function of W and |t| and compared to previous data in photoproduction and deep inelastic scattering and with predictions of QCD-inspired models of exclusive vector-meson production, which are in reasonable agreement with the data.
The impact of vacuum pressure on the effectiveness of SiO2 impregnation of spruce wood
Authors: Lemaire-Paul Mathieu , Beuthe Callisto Ariadne , Riahinezhad Marzieh , Reza Foruzanmehr M. 
Published: December 2022

AbstractWood is a widely used construction material that has many advantageous properties. However, it suffers from weaknesses such as low-dimensional stability and low durability in humid environments. These issues are associated with the porous vascular structure of wood that leads to a high water uptake capacity. This research aims to reduce the water uptake capacity of spruce wood by dip-coating samples in an aqueous colloid of silicon dioxide (SiO2) nanoparticles. SiO2 is a dense ceramic material with good chemical stability. It is readily available and affordable, making it an excellent candidate for this application. This study investigates the effect of SiO2 impregnation on the physico-mechanical properties of spruce wood. Density measurements, water uptake tests, microscopy examination, thermogravimetric analysis, and dynamic mechanical analysis were conducted on non-treated and SiO2-treated spruce wood samples. Quantitative and qualitative analyses demonstrated that SiO2 impregnation performed under higher vacuum pressure was more effective compared to the atmospheric condition and exhibited a greater presence of SiO2 in the wood’s vascular system. SiO2 impregnation under vacuum pressure demonstrated an effective increase in the density of the wood. It also reduced the porosity, which led to a significant reduction in the water uptake of the spruce wood. The analysis of the wood viscoelastic properties revealed that SiO2 impregnation under atmospheric and vacuum conditions triggered two different reinforcing mechanisms. The results showed that a significant improvement of the spruce wood storage and loss moduli could be achieved when impregnation was performed at the highest vacuum pressure of − 90 kPa.
Integrative Bioinformatics Analysis of mRNA Expression Profiles of Mice to Explore the Key Genes Involved in Crim1 Mutation-Induced Congenital Cataracts
Authors: Zhang Ziran , Meng Fanke , Zhou Jing , Zhang Zhihan , Liang Xiaotian , Meng Meijun , Yi Guoguo , Fu Min 
Published: December 2022

AbstractCrim1 has been implicated in cataracts in mice and is of great importance in the development of the eye in both humans and mice. Therefore, we aimed to clarify how Crim1 mutations affect lens development and the molecular mechanism of cataracts in mice through comprehensive bioinformatics analysis. The microarray chip was downloaded from the GEO database to obtain the gene expression profile data set. Differentially expressed genes (DEGs) were screened using the limma package. GO and KEGG analyses of DEGs were performed using the DAVID database. Then, we established the protein–protein interaction (PPI) network in Cytoscape. Next, we used MCODE to analyze the data. We obtained 750 DEGs in total, including 407 upregulated DEGs and 343 downregulated DEGs. GO analysis showed that the DEGs were mainly related to biological processes, such as apoptosis, cell translation and the immune system. KEGG analysis showed that the enriched functions and pathways were related to the processing and presentation of ribosomes, lysosomes, and antigens. We identified 18 HUB genes, among which four core genes, C1qa, C1qb, C1qc, and Cd74, were closely related to congenital cataracts induced by Crim1 mutation. This study reveals the molecular pathogenesis of congenital cataracts induced by Crim1, and this information is expected to facilitate clinical genetic testing, molecular diagnosis, prognosis, and individualized chemotherapy for congenital cataracts (CC).
The association of trastuzumab with atrial fibrillation and heart failure in breast cancer patients in routine clinical practice: a population-based propensity score matching and competing risk model analysis
Authors: Wu Wen-Chi , Huang Chi-Cheng , Tsai Yi-Fang , Lin Yen-Shu , Feng Chin-Jung , Chen Yen-Jen , Lai Jiun-I. , Chao Ta-Chung , Liu Chun-Yu , Tseng Ling-Ming 
Published: December 2022

AbstractPurposeTrastuzumab, a potent anti-human epidermal growth factor receptor 2 (HER2) monoclonal antibody, is conditionally reimbursed by the Taiwan National Health Insurance (NHI) for HER2-positive breast cancer (BC). Trastuzumab-induced cardiotoxicity studies have well characterized heart failure (HF) but fewer addressed arrhythmia, particularly the association of potential life threatening atrial fibrillation (Af) is poorly characterized. We aimed to study the trastuzumab-related risk of Af and HF using the claimed data of Taiwan NHI.MethodsA nationwide retrospective cohort of patients with BC from the Taiwan NHI reimbursement database from January 2007 to December 2016 was analyzed. Propensity score matching and competing risk model analysis were used for adjusting confounding concurrent medication or comorbidities and competing events. The HF study was used to validate the method used.ResultsFor Af, 12,472 trastuzumab users were matched with 12,472 non-trastuzumab users. For HF, 12,241 trastuzumab users and 12,241 non-users were enrolled. We found that trastuzumab users had significantly worse HF-free survival but not Af-free survival than non-trastuzumab users. In the competing risk analysis, the use of trastuzumab did not increase the risk of Af (hazard ratio [HR] 0.76,P = 0.0006) but was associated with HF (HR 1.19,P = 0.0052). The risk trends among stratifications by comorbidities and concurrent medication remained in similar directions for both Af and HF.ConclusionTrastuzumab in real-world practice was associated with an increased risk of HF, but was not associated with an increased risk of Af in BC patients. Trastuzumab-induced arrhythmogenic effects may be masked by concurrent heart-protecting measures, more prominent roles of comorbidities or concurrent medications under real-world settings. Further studies are required.
Decision Theory and De Minimis Risk
Authors: Smith Martin 
Published: December 2022

AbstractA de minimis risk is defined as a risk that is so small that it may be legitimately ignored when making a decision. While ignoring small risks is common in our day-to-day decision making, attempts to introduce the notion of a de minimis risk into the framework of decision theory have run up against a series of well-known difficulties. In this paper, I will develop an enriched decision theoretic framework that is capable of overcoming two major obstacles to the modelling of de minimis risk. The key move is to introduce, into decision theory, a non-probabilistic conception of risk known as normic risk.
Expressive voting versus information avoidance: experimental evidence in the context of climate change mitigation
Authors: Momsen Katharina , Ohndorf Markus 
Published: December 2022

AbstractWe theoretically and experimentally investigate the effect of self-serving information avoidance on moral bias in democratic and individual decisions in the context of climate change mitigation. Subjects choose between two allocations that differ in payoffs and contributions to climate change mitigation. We vary the observability of the environmental contribution, as well as the decision context associated with different levels of pivotality. If the contribution is directly observable, we find evidence for lower pivotality leading to higher levels of “green” decisions, as predicted by the low-cost theory of voting. This effect disappears if subjects can avoid information on the contribution. Instead, we find evidence for the exploitation of moral wiggle room via information avoidance in larger democracies as well as in the consumption context. Our results indicate that information avoidance substitutes expressive voting as an instrument to manage cognitive dissonance on the part of the voter. Hence, moral biases in elections might be less likely than previously thought.
Effect of Part Thickness and Build Angle on the Microstructure, Surface Roughness, and Mechanical Properties of Additively Manufactured IN-939
Authors: Fardan A. , Klement U. , Brodin H. , Hryha E. 
Published: December 2022

Abstract
Powder bed fusion-laser beam of metals (PBF-LB/M) has attracted significant interest due to the possibility of producing dedicated design features like thin-walled structures, even though their mechanical response and microstructure are not well understood. Hence, thin-walled IN-939 structures of different thicknesses (0.5, 1 and 2 mm) were manufactured at two build angles (90 and 45 deg) by PBF-LB/M. A preferred 〈100〉 crystallographic orientation was found along the build direction in all cases. The crystallographic texture intensity and surface roughness increased as the part thickness decreased for 90 deg and increased for 45 deg build angle. Reduction in wall thickness resulted in a decrease in the tensile properties, e.g., YS decreases by up to 33 pct and UTS decreases by up to 30 pct in comparison with the bulk specimen which had YS of 1051 ± 11 MPa and UTS of 1482 ± 9 MPa. Obtained results indicate that the apparent difference in tensile properties is primarily due to the overestimation of the load-bearing area. Two methods to estimate the accurate tensile properties based on roughness compensation are presented, using of which the corrected tensile performance of the thin-walled specimens was comparable with a standard tensile specimen.