bluuebunny/crossref_metadata_2025_split huggingface dataset:
Coarctation of Aorta Fluid Dynamics after Three-Dimensional Reconstruction: A Case Report and Literature Review
Authors: Ou YangDa , Pan Bo , Lv Tiewei , Liu Lifei , Qin Jin jie , Jin Xin , Tian Jie 
Published: March 2023

Abstract
Objective
To investigate the clinical significance of hydrodynamics analysis in diagnosing and treating coarctation of the aorta after three-dimensional reconstruction of CTA.
Methods
The clinical data and imaging data were retrospectively analyzed for a child with coarctation of the aorta and analyzed using computational fluid dynamics combined with relevant literature.
Results
Through the computational fluid dynamics analysis after three-dimensional reconstruction of a child with coarctation of arch, the changes in pressure gradient in the main coarctation section of children's aortic path were deeply discussed and analyzed. The pressure in the coarctation section decreased sharply, the relevant values met the diagnostic criteria, and the hemodynamics could be relieved after surgical anastomosis. Reduced risk of postoperative constriction and postoperative hypertension made surgical intervention feasible. If the hemodynamics of a child could not be alleviated after surgical intervention, interventions such as balloon dilatation or stent could be considered.
Conclusion
Fluid dynamics analysis after three-dimensional reconstruction, under ideal circumstances, could be used to evaluate the overall aortic arch pressure change process more accurately and intuitively with lower cost, less patient pressure, and uncertainty, and has a more comprehensive and systematic guiding significance for the diagnosis and treatment of children with coarctation of the aorta.
One to one marketing management via customer complaint
Authors: Kunathikornkit Shawanluck , piriyakul Intaka , piriyakul Rapepun 
Published: March 2023

Abstract

For companies to retain customers and ensure effective management-level resolution, they need to anticipate customer churn and determine the root cause of complaints. To achieve this, analyzing personalized complaints from the customer's perspective is crucial. This research advocates for a multidisciplinary approach that combines language behavior, relevance feature extraction, feature weighting, and sentiment analysis to extract the underlying problem in real time. Applying this approach to the CFPB database sample yielded an accuracy rate of 82% and a system validity of 75%, which can help improve customer service and protect consumers in the financial and other service industries. By addressing individual customer issues that cause dissatisfaction, businesses can enhance customer satisfaction and retention levels. Thus, by analyzing complaints from a personalized standpoint, companies can identify the root cause of the problem, improve their services, and establish stronger customer relationships.
Thyrotropin releasing hormone and its cyclised C-terminal peptide inhibit thyroglobulin release from thyroid follicular cells: evidence for acute regulation of hormone production at the thyroid gland
Authors: Sun Dijue , Garcia Edwin , The Crystallynn Skye , Raja Umma , Kindt Laura , Collis Dominic W.P. , Azevedo Helena S. , Korbonits Márta , Ghilchik Margaret , King Peter J. , Smyth Derek G. 
Published: March 2023

Abstract
Purpose: Thyrotropin releasing hormone (TRH), a tripeptide hormone produced in the hypothalamus, controls thyroid stimulating hormone (TSH) production from the pituitary gland and hence the production of thyroid hormone. Extra-hypothalamic production and action of TRH has been detected, as has the presence of a C-terminal cyclised derivative, histidyl-proline diketopiperazine (His-Pro DKP). This study investigates the effects of these compounds on thyroglobulin release from thyroid follicular cells.
Methods: DKPs were identified by chromatography and mass spectrometry. Expression of RNAs and proteins were identified in the FTRL-5 thyroid cell line and supernatant using RT-qPCR and immunoblotting.
Results: We show that TRH is expressed by rat follicular thyroid cells, as is Pgpep1, the enzyme required for removal of the N-terminal amino acid of TRH. The rate of His-Pro DKP production from the C-terminal dipeptide of TRH is enhanced by thyroid extract in vitro. Both TRH and His-Pro DKP reduce thyroglobulin release from thyroid follicular cells with the magnitude of this effect attenuated in the presence of TSH, which also inhibits the expression of Pgpep1.
Conclusion: Collectively, these data indicate that TRH and its cyclised dipeptide derivative directly regulate thyroid production within the thyroid gland, potentially in a manner dependent upon the activity of the hypothalamic-pituitary-thyroid (HPT) axis. These findings provide further evidence that C-terminal peptide derivatives of classical hormones possess intrinsic biological activities.
End-of-life care in Germany between 2016 and 2020 – A repeated cross-sectional analysis of statutory health insurance data
Authors: Baal Katharina van , Hemmerling Melissa , Stahmeyer Jona Theodor , Stiel Stephanie , Afshar Kambiz 
Published: March 2023

Abstract
Background
The Hospice and Palliative Care Act of 2015 aimed at developing and regulating the provision of palliative care (PC) services in Germany. However, it remains unknown whether the act has impacted end-of-life care (EoLC) in Germany.
Objective
The present study examined trends in EoLC indicators between 2016–2020, in the context of Lower Saxony, Germany.
Methods
Repeated cross-sectional analysis was conducted on data from the statutory health insurance fund AOK Lower Saxony (AOK-LS), referring to the years 2016–2020. EoLC indicators were: (1) the number of patients receiving any form of outpatient PC, (2) the number of patients receiving generalist outpatient PC and (3) specialist outpatient PC in the last year of life, (4) the onset of generalist outpatient PC and (5) the onset of specialist outpatient PC before death, (6) the number of hospitalisations in the 6 months prior to death and (7) the number of days spent in hospital in the 6 months prior to death. Data for each year were analysed descriptively and a comparison between 2016 and 2020 was carried out using t-tests and chi-square tests.
Results
Data from 160,927 deceased AOK-LS members were analysed. The proportion of patients receiving outpatient PC remained consistent over time (2016 vs. 2020 p = 0.077). The number of patients receiving generalist outpatient PC decreased from 28.4% (2016) to 24.5% (2020; p < .001), whereas the number of patients receiving specialist outpatient PC increased from 8.5% (2016) to 11.2% (2020; p < .001). The onset of generalist outpatient PC moved from 106 (2016) to 93 days (2020; p < 0.001) before death, on average. The onset of specialist outpatient PC showed the reverse pattern (2016: 55 days before death; 2020: 59 days before death; p = 0.041).
Conclusion
Despite growing needs for PC at the end of life, the number of patients receiving outpatient PC did not increase between 2016–2020. Furthermore, specialist outpatient PC is being increasingly prescribed over generalist outpatient PC. Although the early initiation of outpatient PC has been proven valuable for the majority of people at the end of life, generalist outpatient PC was not initiated earlier in the disease trajectory over the study period, as was found to be true for specialist outpatient PC. Future studies should seek to determine how existing PC needs can be optimally met within the outpatient sector and identify factors that can support the earlier initiation of especially generalist outpatient PC.
Trial registration
The study “Optimal Care at the End of Life” was registered in the German Clinical Trials Register (DRKS00015108; 22 January 2019).
From ideal to toxic: controlling the nitrogen environment for optimal Rhodomonas salina production
Authors: Fichtbauer Antonia , Temmink Ralph , Russa Marco La 
Published: March 2023

Abstract
The microalga Rhodomonas salina is a widely used species for rearing live feed organisms in the aquaculture feed market. A species specific media is an essential step towards enhancing productivity and decreasing production costs for microalgae cultivation. However, relevant aspects of media composition such as nitrogen source and elemental ratio have not yet been characterized for this alga. This study aimed to optimize the following three aspects of culture media: 1) optimal ratio between nitrogen and phosphorus (N:P ratio); 2) preferred source of nitrogen; and 3) tolerance of R. salina towards free ammonia. To investigate this, we conducted a series of controlled laboratory experiments in shake flasks. Our experiments revealed a 45% increase in growth rate when an N:P ratio of 15:1 was used compared to the standard ratio of 25:1. Ammonium and nitrate were equally well accepted as a nitrogen source, however, a mix of ammonium and nitrate resulted in significant growth reduction. Free ammonia did not affect growth of the alga at the tested concentrations of up to 5 mg ammonia-nitrogen L− 1. We conclude that for optimal R. salina cultivation, an N:P ratio of 15:1 is strongly preferred, as it leads to a significant increase in growth rate. Further, media with a single source of nitrogen promote faster growth over media with mixed sources, and ammonium may safely be used as a nitrogen source, since R. salina tolerates certain levels of free ammonia. Overall, this work provides insights into the optimal cultivation conditions for R. salina, allowing for more efficient and reliable production of this relevant species.
Effect of Multi-level Intervention on Frequency of Child Occupants’ Safe Behaviors in Iran Using Socio-ecological Model
Authors: Aghdam Fatemeh Bakhtari , Ajami Nahid , Sadeghi-Bazargani Homayoun , Mohammadpoorasl Asghar , Jahangiry Leila 
Published: March 2023

Abstract
Background
This study aims to examines child occupants’ unsafe behaviors and design, implement and evaluate the multi-level intervention program using Socio-ecological model (SEM) to promote child occupants’ safe behaviors.
Methods
This interventional study was conducted in two educational districts of Tabriz, northwest of Iran. SEM was used in two intervention and control groups (n = 160 children per group). The intervention group received educational programs through virtual education application. Messages, images and short videos of unsafe behaviors were sent to students, teachers and parents by this application. Social support was provided through peers, parents and teachers to promote safe behaviors. Interventions were implemented at intrapersonal, interpersonal and social levels. The frequency of unsafe behaviors was examined in both groups before and after intervention.
Results
Behaviors of sitting in the front seat, sitting on the lap of the front passenger, standing in the back seat and sticking hands or other parts of the body out of the window decreased among children by 64.8%, 32.4%, 38% and 84% in the intervention group, respectively (vs. 27%, 23%, 7% and 30.6% in the control group, respectively). However, no statistically significant difference was observed between the two groups in the frequency of using safety seats.
Conclusion
Using multi-level interventions by SEM could reduce child occupants’ unsafe behaviors.
Dynamics of upper respiratory tract infections before, during, and after the COVID-19 pandemic in Germany: a cross-sectional study of 2,167,453 outpatients
Authors: Loosen Sven H. , Plendl Wolfgang , Konrad Marcel , Tanislav Christian , Luedde Tom , Roderburg Christoph , Kostev Karel 
Published: March 2023

Abstract
Background
Although the burden of the COVID-19 pandemic on global healthcare systems is declining, long-term sequelae such as long COVID syndrome and other disease dynamics not primarily associated with COVID-19 remain a challenge. Recent data suggest that the incidence of non-COVID upper respiratory tract infections (URTI) is increasing sharply in the post-pandemic period, but there is a lack of real-world data from Germany in this respect.
Methods
This cross-sectional study evaluated the number of patients with a diagnosis of URTI from the Disease Analyzer database (IQVIA) between January 2019 and December 2022. The number of UTRI diagnoses per practice and the duration of sick leave per patient were compared over time.
Results
A total of 1,872,935 individuals (1,403,907 patients from general practices (GP) and 469,028 patients from pediatric offices) were included, 48% of whom were female. The number of URTI patients per practice was significantly higher in 2022 than in 2019 (732 vs. 464, 58%, p < 0.001) and this was observed for both women (56%, p < 0.001) and men (60%, p < 0.001). The post-pandemic increase in the number of URTI diagnoses correlated with age and was highest in the age group between 18–30 years (22%, p < 0.001) and lowest in older patients > 70 years (3%). In pediatric patients (< 18 years), the increase was highest in the age group ≤ 5 years (89%). Both the number of patients per practice on sick leave due to URTI (184 vs. 92) and the average duration of sick leave (+ 2 days) increased from 2019 to 2022.
Conclusion
Our data suggest a dramatic increase in the incidence of URTI among all demographic subgroups in Germany between 2019 and 2022, which was associated with a tremendous impact on socioeconomic variables such as the frequency or duration of sick leave. These data could be of great importance in current pandemic management and the management of future pandemics.
Security and Network Approach in Smart Environments – Role of SD-WAN Technology
Authors: Saeed Mozamel M. 
Published: March 2023

Abstract
A networking program established to meet current network needs within an extensive network with new architectures. This study presents a novel model of network connections with various devices such as mobile phones and laptops to control overall network management. This study compares and contrasts two home networks, each with its uses. Three linked Alcatel-Lucent 7750 IP service edge routers connect each network to an ISP network. This study builds on multi-carrier assured-service-quality connection tunnels to accommodate multi-ISP scenarios. In this regard, logical manipulation is taken for all connected devices with device abstraction and network programs. Software-Defined Networking (SDN) is a potential option for the future Internet. Two features can define SDN: one is the elimination from the data plane of the control plane, and the other includes programming for the optimization of network applications. SDN can provide additional architecture, efficiency, and versatility for complex applications to meet modern network architectures.
Inhibiting XPOT suppresses TNBC growth via downregulating specific tRNA- TTC19 pathway mediating cytokinesis failure
Authors: Dai Huijuan , Yang Xiaomei , Sheng Xiaonan , Wang Yaohui , Zhang Shan , Zhang Xueli , Hu Lipeng , Zhang Zhigang , Dong Xinrui , Yin Wenjin , Yao Linli , Lu Jinsong 
Published: March 2023

Abstract
Background
Transfer RNAs (tRNAs) are transported to the cytoplasm participating in mRNA translation through carrying cognate aminoacyl amino acids to ribosomes. Accumulating evidence shows that tRNAs play an important role in development and progression of various cancers, including breast cancer. However, it is still poorly clarified whether and how individual tRNA is modulated in triple negative breast cancer (TNBC) progression.
Methods
Clinical value of XPOT was explored in breast cancer cohorts. TNBC cell lines with XPOT silence were used for in vitro and in vivo experiments. RNA-seq, tRNA high throughput sequencing and Protein mass spectrometry of XPOT were performed for exploring the underlying molecular mechanism of XPOT promoting TNBC growth.
Results
XPOT (Exportin-T), a nuclear export protein receptor of tRNAs, was associated with poor prognosis of breast cancer. In vitro experiments showed XPOT knockdown could inhibit TNBC cells proliferation. RNA-seq results indicated that XPOT was involved in the cytokinesis completion of TNBC cells. High throughput sequencing of tRNA revealed that XPOT specifically influenced a subset of tRNA isodecoders nucleo-cytoplasmic trafficking including tRNA-Ala-AGC-10-1. Mechanistically, we found that XPOT preferentially transported nuclear tRNA-Ala-AGC-10-1 to the cytoplasm and drove the translation of TPR Repeat Protein 19 (TTC19) through codon preferential analysis and protein mass spectrometry analysis. TTC19 was also indispensable for cytokinesis and proliferation of TNBC cells.
Conclusions
Together, these findings provide a novel regulatory translation mechanism of preferential tRNA isodecoder nucleo-cytoplasmic transport through XPOT to modulate biological behavior of TNBC. This regulation mode could coordinate the spatial location of specific tRNA and the translation of mRNA, to facilitate TNBC proliferation and progression. Targeting XPOT may serve as a novel potential therapeutic strategy for TNBC.
High-Flow Nasal Cannula Oxygen Therapy during Deep Intravenous Sedation for Cataract Surgery in the Elderly: A Case Report
Authors: Nafeh Nancy Abou , Harb Alain , Karam Cynthia , Mroueh Raghad , khalili amro 
Published: March 2023

Abstract
In a multidisciplinary approach between the anesthesiologist and the ophthalmologist, we report the successful use of high-flow nasal canula (HFNC) oxygen therapy in a sedated, obese, anxious, old patient undergoing cataract surgery under deep intravenous (IV) sedation to eliminate his upper airway obstruction, heavy snoring, apnea, and oxygen desaturation while using a regular nasal cannula for oxygen supply, thus avoiding the need for general anesthesia with endotracheal intubation or case cancelation.
Estimation of potential nutrient fluxes from the Wadi Gaza catchment into the Mediterranean Sea with emphasis on flooding events
Authors: Al-Najjar Hassan , Purnama Anton , Özkan Korhan 
Published: March 2023

AbstractThe coastal catchment of Wadi Gaza is the main surface water basin that flows downstream to Gaza's coastal plain zone and drains into the Mediterranean Sea. The model-based assessment of the Wadi Gaza hydrological system is an essential endeavor for more efficient management of water resources and ensuring water security in terms of climate changes and anthropogenic processes. The hydrological simulation of the basin was performed using the SWAT model between 1984 and 2020. The outputs of the simulation predicted an average discharge that varies between zero in the summer months and about 15 m3/s in the winter with a maximum recorded discharge of about 130 m3/s. The model predicted average sediment and nutrient discharge to the sea as 3673, 177, and 62 tons per month of sediments, total nitrogen (TN), and total phosphorus (TP), respectively. The average dissolved inorganic nitrogen discharges were predicted to be 4, 13, and 1 tons per month for Nitrate (NO3), Ammonium (NH4), and Nitrogen dioxide (NO2), respectively during the rainy season. The constructed model is used to predict flood volumes and associated TN and TP for return periods (T) of 2, 25, 50, and 100 years. These return periods corresponded to total water discharges of 18, 91, 105, and 127 m3/s, respectively, accounting for 1,142, 5,773, 6,915, and 8,059 tons of TN, and 414, 2,092, 2,505, and 2,919 tons, of TP respectively.
Perspectives on Iron Deficiency as a Cause of Human Disease in
Global Public Health
Authors: Bjørklund Geir , Semenova Yuliya , Hangan Tony , Pen Joeri J. , Aaseth Jan , Peana Massimiliano 
Published: March 2023

Abstract:
Iron (Fe) is a necessary trace element in numerous pathways of human
metabolism. Therefore, Fe deficiency is capable of causing multiple health problems.
Apart from the well-known microcytic anemia, lack of Fe can cause severe psychomotor
disorders in children, pregnant women, and adults in general. Iron deficiency is a global
health issue, mainly caused by dietary deficiency but aggravated by inflammatory conditions.
The challenges related to this deficiency need to be addressed on national and international
levels. This review aims to summarize briefly the disease burden caused by Fe
deficiency in the context of global public health and aspires to offer some hands-on guidelines.
Stunting prevention: how to differentiate stunting and short stature. A community service webinar with aisyiyah regional leader in malang
Authors: Pertiwi Febriana Chandrawati  , Akbari Agung Nusantara  
Published: March 2023

Background: The issue of stunting and short stature continues to receive attention from the Indonesian government because it will determine the quality of Indonesian Human Resources in the future. Stunting is short, but short is not necessarily stunting. Stunting is a condition of failure to thrive due to malnutrition in the first thousand days of a child's life.Short-stature is at risk of stunting if the problem is not immediately resolved. Protein intake from animal meat is playing as an essential role in preventing stunting. Purpose: The program aims to increase the knowledge of the Aisyiyah regional leader in Malang in distinguishing between short stature and stunting and how to prevent it. Method: We conducted a seminar online using the pandemic COVID-19-prevention-protocol. Participantsasked questions and discussedthis topic. Conclusion: A working group program and pocketbook in stunting prevention in children as a collaboration between the medical faculty of the University of Muhammadiyah Malang, the regional leader of Aisyiyah Malang, and Dewan Pimpinan Wilayah of Muhammadiyah advisor will be formed.
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The manifestations of modern degassing in the heat flow and deep structure (on the example of Lohvytsky block of Dnieper-Donetsk basin)
Authors: Usenko O.V. , Usenko A.P. 
Published: March 2023

The article contains heat flow calculations in the Lokhvytsky block and a scheme of the distribution of heat flow. We found the dependence of heat flow distribution with zones of activated deep faults of the crystal basement, sedimentary cover of Sribnenska depression and its surroundings. At the borders of Lokhvytsky block the heat flow in the area changes only a little, staying close to the average value — 40 mWt/m2. At all deposits the gradient increases by 20—30 °С/m, which happens at the intersection of tectonic, stratigraphic and lithological borders, which in many cases control the location of hydrocarbon deposits as well.
Changes of temperature and composition of waters at the depth where the gradient jumps let us assume that their reason is modern hydrothermal activity. To find its manifestations, we incorporated geophysical research that determined the fault zones and zones of decompression, to which hydrocarbon deposits tend. The connection between thermal water discharge zones and faults is confirmed by their enrichment with hydrogen, helium, and the presence of native metal particles.
Fault zones, which limit the Sribnenska depression and the Kherson—Smolensk transregional tectonic seam are shown at the crust structure, established by a two-dimensional speed model of seismic Р waves in the Еarth’s crust (GEORIFT 2013 profile). The results of seismotomographic research show the complex structure of the mantle, directly under the study area.
Geophysical data demonstrate that faults manifested in the crystalline basement and sedimentary strata control the location of high-velocity blocks in the crust. The continuation of faults to the boundary of the crust and mantle is unquestionable. The inhomogeneities of the structure of the upper mantle and the transition layer, reflected in the seismotomographic model, can be traced directly under the Sribne depression to the lower mantle. This allows us to assume, as a working hypothesis, the existence of a chain of geodynamic processes that are manifested on the surface in hydrothermal activity.