bluuebunny/crossref_metadata_2025_split huggingface dataset:
Autologous blood resuscitation for large animals in a research setting using the Hemafuse device: Preliminary data of device use for controlled and real-world hemorrhage
Authors: Treffalls Rebecca N. , Lubas Matthew , Morrison Jonathan J. , Stonko David P. 
Published: December 2022

IntroductionNew low-cost technologies are needed to salvage lost blood in low-resource settings and large animal laboratories. The Hemafuse device is a simple mechanical device that can recover lost blood during surgery. The aim of this study is to assess the feasibility of this device for resuscitating large animals with controlled and unintended hemorrhage and to provide device considerations for use in this context.MethodsThis study had two experimental components: (1) the Hemafuse device was kept on-shelf and used as needed to assess real-world use for unintended hemorrhage during experiments, and (2) animals underwent a controlled hemorrhage protocol, where four anesthetized swine underwent aortic and external jugular vein catheterization for pressure monitoring. Animals were hemorrhaged into the pelvis, and the Hemafuse device was used to suction the blood through a filter and pushed into a heparinized bag for subsequent retransfusion. Blood samples were collected at baseline, hemorrhage, within the device, and post-retransfusion and laboratory tests were performed.ResultsAnimals that underwent controlled hemorrhage had a baseline mean arterial pressure of 83.6 ± 7.8 mmHg, and central venous pressure of 12.8 ± 1.9 mmHg, with expected changes throughout hemorrhage and resuscitation. Following resuscitation, pH was similar to baseline (7.39 ± 0.05 vs. 7.31 ± 0.03,p= 0.24). Lactate increased throughout the experiment with no significant differences after autotransfusion compared to baseline (2.7 ± 0.7 vs. 4.1 ± 1.4 mmol/L,p= 0.37). There were no significant changes in metabolic physiology. Compared to baseline, the hemoglobin (7.8 ± 2.4 vs. 7.3 ± 1.8 g/dL,p= 0.74), hematocrit (23% ± 6.9 vs. 21.3% ± 5.6,p= 0.71), and activated clotting time (268.5 ± 44.5 vs. 193 ± 24.6 s,p= 0.35) were similar after retransfusion. When used for unintended hemorrhage, the animals were resuscitated using the device with a mean time to retransfusion time of 128.7 ± 13.3 s and 100% survival throughout the experiment.ConclusionThe Hemafuse device is feasible and efficacious for supporting large animal resuscitation. This is preliminary evidence that the device is a low-risk and low-cost off-the-shelf option for resuscitation using autologous blood with no significant effect on physiology post-retransfusion. We recommend that research laboratories consider the Hemafuse device for emergency use, particularly for highly invasive surgical laboratories where banked blood is not readily available.
Anti-Amnesic Effect of Synbiotic Supplementation Containing Corni fructus and Limosilactobacillus reuteri in DSS-Induced Colitis Mice
Authors: Lee Hyo Lim , Kim Jong Min , Moon Jong Hyun , Kim Min Ji , Jeong Hye Rin , Go Min Ji , Kim Hyun-Jin , Eo Hyun Ji , Lee Uk , Heo Ho Jin 
Published: December 2022

This study was conducted to compare the synbiotic activity between Corni fructus (C. fructus) and Limosilactobacillus reuteri (L. reuteri) on dextran sulfate sodium (DSS)-induced colitis and cognitive dysfunction in C57BL/6 mice. C. fructus (as prebiotics, PRE), L. reuteri (as probiotics, PRO), and synbiotics (as a mixture of L. reuteri and C. fructus, SYN) were fed to mice for 3 weeks. Consumption of PRE, PRO, and SYN ameliorated colitis symptoms in body weight, large intestinal length, and serum albumin level. Moreover, SYN showed a synergistic effect on intestinal permeability and intestinal anti-inflammation response. Also, SYN significantly improved cognitive function as a result of measuring the Y-maze and passive avoidance tests in DSS-induced behavioral disorder mice. Especially, SYN also restored memory function by increasing the cholinergic system and reducing tau and amyloid β pathology. In addition, PRE, PRO, and SYN ameliorated dysbiosis by regulating the gut microbiota and the concentration of short-chain fatty acids (SCFAs) in feces. The bioactive compounds of C. fructus were identified with quinic acid, morroniside, loganin, and cornuside, using ultra-performance liquid chromatography-quadrupole time-of-flight tandem mass spectrometry (UPLC-Q-TOF-MS2). In conclusion, synbiotic supplementation alleviated DSS-induced colitis and cognitive dysfunction by modulating gut microbiota, proinflammatory cytokines, and SCFAs production.
Evidence for Reconsidering the Taxonomic Status of Closely Related Oligonychus Species in punicae Complex (Acari: Prostigmata: Tetranychidae)
Authors: Mushtaq Hafiz Muhammad Saqib , Kamran Muhammad , Saleh Amgad A. , Alatawi Fahad Jaber 
Published: December 2022

To elucidate the taxonomic problems in species delineation within the Oligonychus punicae complex (O. punicae, O. mangiferus, and O. vitis) (Acari: Prostigmata: Tetranychidae), we performed morphological and molecular investigations on mite samples, collected from different hosts/countries. Thirty-nine samples of punicae complex, collected from Egypt, Pakistan, and Saudi Arabia (SA), did not show any considerable morphological differences in females and males. All 39 samples of the punicae complex resembled the original description of O. punicae, while the claimed Mexican O. punicae was distinctively different based on male aedeagus. Molecularly, the low nucleotide diversity ranged from 0% to 2.1% (ITS2-rDNA) and 0% to 1% (COI-mtDNA), and was observed among various DNA sequences of the punicae complex from Egypt, India, Israel, Pakistan, and SA, confirming their identity as one species. The high genetic divergence ranged from 17.2% to 18.8% (ITS2) and 9.2% to 10.2% (COI), observed between the claimed Mexican O. punicae and all other sequences of the punicae complex, indicating that the Mexican sample do not belong to O. punicae. Basing our findings on both morphological and molecular data, we can conclude that O. mangiferus and O. vitis are synonymized with O. punicae. Additionally, this study reveals that the claimed Mexican O. punicae needs to be re-identified.
Beneficial Effects of Limosilactobacillus fermentum in the DCA Experimental Model of Irritable Bowel Syndrome in Rats
Authors: Rodríguez-Sojo María Jesús , Garcia-Garcia Jorge , Ruiz-Malagón Antonio Jesús , Diez-Echave Patricia , Hidalgo-García Laura , Molina-Tijeras José Alberto , González-Lozano Elena , López-Escanez Laura , Rodríguez-Cabezas María Elena , Rodríguez-Sánchez Maria José , Rodríguez-Nogales Alba , Mediavilla Cristina , Galvez Julio 
Published: December 2022

Limosilactobacillus fermentum CECT5716, a probiotic strain isolated from human milk, has reported beneficial effects on different gastrointestinal disorders. Moreover, it has shown its ability to restore altered immune responses, in association with microbiome modulation in different pathological conditions. Therefore, our aim was to assess the effects of a Limosilacbacillus fermentum CECT5716 in a rat experimental model of irritable bowel syndrome (IBS) that resembles human IBS. The experimental IBS was induced by deoxycholic acid (DCA) in rats and then, Limosilactobacillus fermentum CECT5716 (109 CFU/day/rat) was administered. Behavioral studies, hyperalgesia and intestinal hypersensitivity determinations were performed and the impact of the probiotic on the inflammatory and intestinal barrier integrity was evaluated. Additionally, the gut microbiota composition was analyzed. Limosilactobacillus fermentum CECT5716 attenuated the anxiety-like behavior as well as the visceral hypersensitivity and referred pain. Moreover, this probiotic ameliorated the gut inflammatory status, re-establishing the altered intestinal permeability, reducing the mast cell degranulation and re-establishing the gut dysbiosis in experimental IBS. Therefore, our results suggest a potential use of Limosilactobacillus fermentum CECT5716 in clinical practice for the management of IBS patients.
Adsorbed Oxygen Ions and Oxygen Vacancies: Their Concentration and Distribution in Metal Oxide Chemical Sensors and Influencing Role in Sensitivity and Sensing Mechanisms
Authors: Ciftyurek Engin , Li Zheshen , Schierbaum Klaus 
Published: December 2022

Oxidation reactions on semiconducting metal oxide (SMOs) surfaces have been extensively worked on in catalysis, fuel cells, and sensors. SMOs engage powerfully in energy-related applications such as batteries, supercapacitors, solid oxide fuel cells (SOFCs), and sensors. A deep understanding of SMO surface and oxygen interactions and defect engineering has become significant because all of the above-mentioned applications are based on the adsorption/absorption and consumption/transportation of adsorbed (physisorbed-chemisorbed) oxygen. More understanding of adsorbed oxygen and oxygen vacancies (VO•,VO••) is needed, as the former is the vital requirement for sensing chemical reactions, while the latter facilitates the replenishment of adsorbed oxygen ions on the surface. We determined the relation between sensor response (sensitivity) and the amounts of adsorbed oxygen ions (O2(ads)−, O(ads), −O2(ads)2−, O(ads)2−), water/hydroxide groups (H2O/OH−), oxygen vacancies (VO•, VO••), and ordinary lattice oxygen ions (Olattice2−) as a function of temperature. During hydrogen (H2) testing, the different oxidation states (W6+, W5+, and W4+) of WO3 were quantified and correlated with oxygen vacancy formation (VO•, VO••). We used a combined application of XPS, UPS, XPEEM-LEEM, and chemical, electrical, and sensory analysis for H2 sensing. The sensor response was extraordinarily high: 424 against H2 at a temperature of 250 °C was recorded and explained on the basis of defect engineering, including oxygen vacancies and chemisorbed oxygen ions and surface stoichiometry of WO3. We established a correlation between the H2 sensing mechanism of WO3, sensor signal magnitude, the amount of adsorbed oxygen ions, and sensor testing temperature. This paper also provides a review of the detection, quantification, and identification of different adsorbed oxygen species. The different surface and bulk-sensitive characterization techniques relevant to analyzing the SMOs-based sensor are tabulated, providing the sensor designer with the chemical, physical, and electronic information extracted from each technique.
Analisis Perputaran Piutang pada Perusahaan
Authors: Nurjanah Gebi Lia , Handayani Anita 
Published: December 2022

Credit sales are made by companies with the hope that they will increase product sales at the company. In the last 3 years the company 's sales have fluctuated (not stable). If sales fluctuate, receivables will also experience the same thing. With this happening, the company must be able to manage receivables properly so that bad debts do not occur in the company. The purpose of this research is to analyze the level of accounts receivable turnover in 2019-2021. This study used a descriptive qualitative method by conducting interviews and collecting data in the form of documents that aim to create an accurate picture of the facts and phenomena that occur in accounts receivable turnover. Based on data analysis carried out on the source of PT ABC's financial statements in 2020, the turnover of accounts receivable was 28.48 times in one period and the age of receivables was 13 days. In 2021, receivables turnover is 75.39 times in one period and receivables are aged for 5 days. Based on the SOP that has been set by the company, the overall management of receivables turnover at PT ABC from 2019-2021 has been well managed because the company is able to collect its receivables very quickly and before they are due.
THE RELATIONSHIP BETWEEN KNOWLEDGE OF PREGNANCY DANGER SIGNS IN PREGNANT WOMEN AND COMPLIANCE WITH PREGNANCY CHECKUPS AT THE JAGAKARSA SUB-DISTRICT HEALTH CENTER, SOUTH JAKARTA
Authors: Hikma Wd Erty , Mustikawati Mustikawati 
Published: December 2022

Kehamilan merupakan proses alamiah yang akan dialami oleh setiap wanita. Perubahan fisiologis pada masa kehamilan, persalinan, nifas, dan neonatus sewaktu-waktu dapat berubah menjadi patologis, ini ditimbulkan karena banyaknya faktor yang mempengaruhi. Dari setiap kondisi patologis pada masa kehamilan, persalinan, nifas, dan neonatus, akan memperlihatkan adanya tanda bahaya pada masalah tersebut, yang apabila diketahui secara dini dapat menyelamatkan jiwa ibu dan bayinya. Kebaruan penelitian ini yaitu mengetahui hubungan antara pengetahuan tanda bahaya kehamilan dengan kepatuhan pemeriksaan kehamilan pada ibu hamil. Tujuan penelitian ini ialah untuk mengetahui hubungan pengetahuan ibu hamil tentang tanda bahaya kehamilan dengan kepatuhan pemeriksaan kehamilan. Metode Penelitian observasional analitik dengan menggunakan pendekatan cross sectional, dengan jumlah sampel 90 responden. Analisa data menggunakan chi square. Hasil: Sebagian besar responden memiliki pengetahuan tinggi yaitu sebanyak 57,8% responden, dan sebagian besar responden memiliki perilaku tepat yaitu sebanyak 64,4% responden. Nilai uji statistik diperoleh nilai p = 0,008, Î± = 0,05. Dengan tingkat kepercayaan 95% diperoleh nilai OR = 3,704 (1,496 â€“ 9,169). Kesimpulan: Ada hubungan pengetahuan tentang tanda bahaya kehamilan pada ibu hamil dengan kepatuhan pemeriksaan kehamilan.Kata kunci: Pengetahuan; Kepatuhan; Kehamilan.Â AbstractPregnancy is a natural process that every woman will experience. Physiological changes in the period of pregnancy, childbirth, puerperium, and neonates can at any time turn pathological, this is due to the large number of influencing factors. From every pathological condition during pregnancy, childbirth, puerperium, and neonates, before an emergency occurs that will show red flags of the problem, which if known early can save the life of the mother and her baby. The novelty of this study is to know the relationship between knowledge of pregnancy danger signs in pregnant women and compliance with pregnancy checks. The purpose of this study was to determine the relationship between pregnant women's knowledge of pregnancy danger signs and compliance with pregnancy checks. Analytical observational research method using a cross sectional approach, with a total sample of 90 respondents. Data analysis using chi squere. Results: Most respondents had high knowledge of 57.8% of respondents, and most respondents had the right behavior, with 64.4% of respondents. The statistical test value obtained p value = 0.008, Î± = 0.05. With a confidence level of 95% obtained the value of OR = 3.704 (1.496 â€“ 9.169). Conclusion: There is a relationship of knowledge about the danger signs of pregnancy in pregnant women with the observance of pregnancy checks.
PENGARUH PENINGKATAN KEMAMPUAN KERJA, PELATIHAN KERJA DAN KOMUNIKASI TERHADAP PENINGKATAN PERfORMANCE KARYAWAN PMI KOTA YOGYAKARTA
Authors: Indriyanti Aris 
Published: December 2022

Sumber daya manusia merupakan komponen terpenting dalam suatu organisasi. PMI kota Yogyakarta merupakan organisasi yang bergerak dibidang kemanusiaan dan kerelawanan memberikan pelayanan kepada masyarakat. Kompetensi dan pengelolaan sumber daya manusia sangat diperlukan untuk dapat bersaing. Salah satunya dengan melihat kemampuan kerja, pelatihan dan komunikasi dalam organisasi terhadap performance karyawan. Metode Penelitian menggunakan metode kuantitatif dengan pendekatan Cross Sectional. Sampel penelitian ini sebanyak 61 responden. Data diperoleh melalui kuesioner, setelah data diperoleh penelitian analisis dengan menggunakan teknik analisis regresi linear berganda.
Hasil uji hipotesis didapatkan bahwa variabel kemampuan kerja, pelatihan dan komunikasi berpengaruh terhadap performance karyawan dibuktikan dengan tingkat signifikikansi <0,05. Variabel pelatihan lebih berpengaruh terhadap performance karyawan daripada variabel lain. ditandai dengan nilai t pelatihan > dari pada nilai t komunikasi dan kemampuan kerja. Besarnya pengaruh pelatihan, kemampuan kerja dan komunikasi adalah sebesar75 %.
Sinergitas Guru dan Orang Tua dalam Menumbuhkan Minat Belajar Anak di Lembaga Pendidikan Madrasah Ibtidaiyah Bustanul Ulum
Authors: Ulum M.Bustanul 
Published: December 2022

The Covid-19 pandemic period has not yet passed, the world of education is in a polemic between complying with government regulatory policies and the importance of learning for the nation's young generation, which until now are still doing online learning. There are many pros and cons in dealing with this. Then a number of problems arise and one of the problems we often see today is the declining interest in children's learning and the lack of support from parents. Interest in learning decreased due to students experiencing boredom in online learning. Besides that, face-to-face learning is considered more capable of boosting children's interest in learning, as well as fostering a high understanding of the learning material presented by the teacher. Technological tools in the form of mobile phones as a source of children's learning are not maximally able to foster children's interest in learning. They more often use mobile phones as a tool to play and play, learning is no longer efficient. As an educator, I must be able to build synergy with students and also their parents and the surrounding community. And one of the synergies that have been built is in the form of an organization, because in my opinion, from the several approach strategies that I have taken, Gratefuly, there have been significant changes. This also happened because of the support from parents.
Keywords: Synergy, Interest in Learning, Parental Support, Planning
Activity of 2-[3-(2-chloroethyl)-3-nitrosoureido]-1,3-propandyоl (chlonisol) versus lomustine in intracranial transplanted tumor model in mice
Authors: Zmitrichenko Yu. G. , Stukov A. N. , Aleksandrov V. А. , Tochilnikov G. V. , Murazov I. G. , Latipova D. Н. , Filatova L. V. , Semiglazova T. Yu. 
Published: December 2022

Background. Alkylating drugs have been used in tumor chemo therapy for many decades, and the search for effective compounds continues.The aim of the study was to study the activity of the developed new compound – 2-[3-(2-chloroethyl)-3-nitrosoureido]-1,3-propanediol (chlonisol) in comparison with lomustine (CCNU) from the nitrosoalkylurea group, which is similar in chemical structure, in the model of intracranially transplanted Ehrlich's tumor and sarcoma 180 in mice.Methods. According to the developed technique, 64 female mice of the BALB/c line were punctured in the skull under anesthesia and inoculated with tumor cells of Ehrlich's carcinoma or sarcoma 180 in 0.9 % sodium chloride solution. After 24 hours, the test substances were administered at the maximum tolerated doses – chlonisol (20 mg/kg, i.p.) and lomustine (50 mg/kg, orally), once. The effect was compared with the control (solvent injection).Results. Chlonisol significantly increased the median overall survival (MOS) of animals after intracranial transplantation of both Ehrlich's tumor (by 39 %) and sarcoma 180 (by 84 %) compared with control (p<0.0001). Chlonisol reduced the risk of death in mice by 73 % compared to control in Ehrlich tumor transplantation and by 83 % in sarcoma 180 (p<0.0001). In contrast, lomustine did not show a significant therapeutic effect in intracranial transplantation of both tumors.Conclusion. The high activity of chlonisol in comparison with lomustine gives reason to consider it as a potential cytostatic agent in the treatment of nervous system tumors.
Técnicas de Irrigação, o Desenvolvimento da Agricultura e do Agronegócio: uma Análise à Luz da Proteção Humana e da Cidadania Frente à Crise Hídrica Nacional
Authors: Soares Macedo Maria Fernanda 
Published: December 2022

O objetivo do presente estudo é trazer considerações acerca da importância das técnicas de irrigação na agricultura e no agronegócio no Brasil, em especial no Nordeste, com o enfoque para buscas de alternativas, frente à crise hídrica nacional, que teve um de seus momentos mais críticos em 2014, permanece em 2015 e tem perspectiva de continuar nos próximos anos. A irrigação tem por objetivo fornecer água em quantidade adequada para o plantio e a colheita dos produtos cultivados. Diversas são as destinações dos produtos colhidos, como a alimentação das pessoas e animais, as bases para a produção de diversos medicamentos, de produtos químicos, combustíveis, fibras, bem como as vendas dos produtos agrícolas em mercado interno e internacional. A crise hídrica, entretanto, afeta diretamente este importante setor produtivo. Além da seca, de plantações prejudicadas com a falta de água, outras consequências são a diminuição da produção agrícola, desabastecimento de hortaliças, falta de leguminosas e demissão de funcionários. Todas estas consequências afetam diretamente tanto a proteção da dignidade humana quanto a cidadania. Frente a este quadro, são fundamentais as inovações, especialmente para as técnicas de irrigação.
علل اختلاف مرويات عبدالرحمن بن مهدي ووكيع في الرواية عن الإمام الثوري (دراسة نقدية تطبيقية مقارنة)
Authors: Talib Hammad Abu Shaar  
Published: December 2022

This research deals with the problem of the difference between Imam Ibn Mahdi and Imam Wakee of Sufyan al-Thawri
The aim of the researcher is to identify the narrations that are based on the difference on it, and the weighting between them.
The researcher read; The places of disagreement in the hadiths between Ibn Mahdi and Waki’ in the narration on the authority of Al-Thawri, and I found twelve hadiths, the researcher studied them, and clarified the places of disagreement, and weighted them, and explained their reasons and the faces of error and right in them.
In the applied study, the researcher found the validity of Ibn Mahdi’s narration, in the most hadiths in which he differed with Wakee’ in the narration on the authority of Al-Thawri.
Evidence of a Nonorthogonal X-line in Guide-field Magnetic Reconnection
Authors: Pathak Neha , Ergun R. E. , Qi Y. , Schwartz S. J. , Vo T. , Usanova M. E. , Hesse M. , Phan T. D. , Drake J. F. , Eriksson S. , Ahmadi N. , Chasapis A. , Wilder F. D. , Stawarz J. E. , Burch J. L. , Genestreti K. J. , Torbert R. B. , Nakamura R. 
Published: December 2022

Abstract
We present observations that suggest the X-line of guide-field magnetic reconnection is not necessarily orthogonal to the plane in which magnetic reconnection is occurring. The plane of magnetic reconnection is often referred to as the L–N plane, where L is the direction of the reversing and reconnecting magnetic field and N is normal to the current sheet. The X-line is often assumed to be orthogonal to the L–N plane (defined as the M-direction) in the majority of theoretical studies and numerical simulations. The four-satellite Magnetospheric Multiscale (MMS) mission, however, observes a guide-field magnetic reconnection event in Earth’s magnetotail in which the X-line may be oblique to the L–N plane. This finding is somewhat opportune as two of the MMS satellites at the same N location report nearly identical observations with no significant time delays in the electron diffusion region (EDR) even though they have substantial separation in L. A minimum directional derivative analysis suggests that the X-line is between 40° and 60° from M, adding support that the X-line is oblique. Furthermore, the measured ion velocity is inconsistent with the apparent motion of the MMS spacecraft in the L-direction through the EDR, which can be resolved if one assumes a shear in the L–N plane and motion in the M-direction. A nonorthogonal X-line, if somewhat common, would call for revisiting theory and simulations of guide-field magnetic reconnection, reexamination of how the reconnection electric field is supported in the EDR, and reconsidering the large-scale geometry of the X-line.