bluuebunny/crossref_metadata_2025_split huggingface dataset:
Jejunal gastrointestinal stromal tumor that developed in a patient with neurofibromatosis type 1: a case report
Authors: Nagano Hideki , Ohyama Shigekazu , Sato Atsushi , Igarashi Jun , Yamamoto Tomoko , Kadoya Masumi , Kobayashi Mikiko 
Published: June 2023

Abstract
Background
Neurofibromatosis type 1 (NF1) is known to be associated with the frequent occurrence of unique gastrointestinal stromal tumors (GISTs). Whereas most sporadic GISTs occur in the stomach and possess mutations in the c-kit proto-oncogene or platelet-derived growth factor receptor-alpha (PDGFRA), NF1-related GISTs develop most commonly in the small intestine and are not accompanied by c-kit or PDGFRA mutations. NF1-related GISTs also have a high tendency for multifocal development, indolent nature, low proliferation activity and favorable prognosis.
Case presentation
A 41-year-old woman visited her local doctor complaining of menorrhalgia; a large mass was detected in her lower abdomen, and she was referred to our hospital. The patient had hundreds of skin warts and café au lait spots. Ultrasonography showed a large heterogeneous cystic mass with various echo patterns indicating fluid-fluid levels, solid compartments and multiple septations. Magnetic resonance imaging showed a multilocular cystic mass with liquid content exhibiting various intensities, including that of blood. A small round solid mass was also observed close to the cystic tumor. Contrast-enhanced computed tomography showed that the round solid mass showed strong enhancement in the early phase, unlike the cystic tumor component. Open laparotomy revealed a multicystic exophytic tumor measuring 11.5 cm originating from the jejunal wall, 20 cm distal to the duodenojejunal flexure. A solid tumor measuring 2.1 cm was also found on the anal side of the large tumor. We resected the short segment of the jejunum, including the two lesions. Microscopic findings revealed that the cystic and solid tumor consisted of spindle-shaped tumor cells showing little atypia with a fascicular or bundle arrangement. Nuclear mitosis was scarce. Immunostaining of the tumor cells showed positive staining for KIT and DOG1 and negative staining for S100 and desmin. The NF1 patient was diagnosed with multiple GISTs accompanied by intratumoral hemorrhagic denaturation arising from the jejunum. The TNM staging was pT4N0M0,
stage IIIA.
Conclusion
We report a case of GISTs associated with NF1 that showed clinical manifestations atypical of sporadic GISTs, had a jejunal origin, showed multifocal development and had few mitotic figures. The recurrence risk and survival prognosis of NF1-related GISTs have not been sufficiently clarified and remain to be elucidated.
Do domestic budgerigars perceive predation risk?
Authors: Wang Chang , Zhao Xueqi , Tao Baodan , Peng Jiaqi , Wang Haitao , Yu Jiangping , Jin Longru 
Published: June 2023

Abstract
Predation risk may affect the foraging behavior of birds. However, there has been little research on the ability of domestic birds to perceive predation risk and thus adjust their feeding behavior. In this study, we tested whether domestic budgerigars (Melopsittacus undulates) perceived predation risk after the presentation of specimens and sounds of sparrowhawks (Accipiter nisus), domestic cats (Felis catus), and humans, and whether this in turn influenced their feeding behavior. When exposed to visual or acoustic stimuli, budgerigars showed significantly longer feeding latency under sparrowhawk, domestic cat, and human treatments than with controls. Budgerigars responded more strongly to acoustic stimuli than visual stimuli, and they showed the longest feeding latency and the least number of feeding times in response to sparrowhawk calls. Moreover, budgerigars showed shorter feeding latency and greater numbers of feeding times in response to human voices than to sparrowhawk or domestic cat calls. Our results suggest that domestic budgerigars may identify predation risk through visual or acoustic signals and adjust their feeding behavior accordingly.
Efficient synthesis of 2’-deoxyguanosine by employing an engineered purine nucleoside phosphorylase from Brevibacterium acetylicum in one-pot cascade
Authors: Xu Lian , Li Hui-Min , Lin Juan 
Published: June 2023

Abstract
2’-deoxyguanosine is a key medical intermediate which could be applied for the synthesis of anti-cancer drug and biomarker in type 2 diabetes. In present study, an enzymatic cascade for the efficient synthesis of 2’-deoxyguanosine was proposed by employing thymidine phosphorylase from Escherichia coli (EcTP) and purine nucleoside phosphorylase from Brevibacterium acetylicum (BaPNP) in a one-pot whole cell catalysis. Semi-rational design of BaPNP was performed to enhance its activity, resulting a best triple variant BaPNP-Mu3 (E57A/T189S/L243I), with an overall 5.6-fold higher yield of 2'-deoxyguanosine as compared with BaPNP-Mu0. Molecular dynamics simulation revealed that the engineering of BaPNP-Mu3 led to a larger and more flexible substrate entrance channel, which might contribute to its catalytic performance. Furthermore, by coordinating the expression of BaPNP-M3 and EcTP, a robust whole cell catalyst W05 was constructed, which could produce 14.8 mM 2’-deoxyguanosine with a high time-space yield (1.32 g/L/h) and therefore was very competitive for industrial applications.
Morpho-biochemical responses of rice genotypes against leaffolder, Cnaphalocrocis medinalis, Guenee
Authors: Nayak Anjan Kumar , Golive Prasanthi , Sasmal Arundhati , Adak Totan , Kumar Gaurav , Dash Soumya Shephalika , Patil Naveenkumara B. , Mohapatra Shyamaranjan Das 
Published: June 2023

Abstract
Rice leaffolder, Cnaphalocrocis medinalis, Guenee is a serious pest of rice and causes significant yield losses. Insecticides are commonly employed to control this pest, but their use often escalates production costs and fosters pesticide resistance. Identifying insect-resistant rice genotypes and their resistance mechanisms is crucial for successful pest management. New sources of resistance providing long-lasting protection against leaffolder can be identified by studying the morphobiochemical characteristics of different rice genotypes. This study explored the role of various morphological traits of certain genotypes that confer resistance. Different biochemical constituents like soluble protein, phenol, total soluble sugar and enzymes viz., peroxidase, polyphenol oxidase and catalase were assessed spectrophotometrically in all infested and uninfested genotypes along with standard resistant (TKM6) and susceptible (TN1) checks. Leaffolder damage was negatively significant with plant height and leaf length (r = -0.903 and − 0.862, P < 0.001 respectively) while leaf width association was significantly positive (r = 0.773, P < 0.001). Among the different plant metabolites analyzed, total soluble sugar and soluble protein showed significant positive correlation (r = 0.778 and 0.788, P < 0.001 respectively) with leaffolder damage, conversely phenol (r = -0.651, P < 0.001) and antioxidative enzymes showed significant negative correlation. When rice genotypes were exposed to leaffolder larval feeding, they exhibited defence responses characterized by reduction in the level of sugars and proteins, accumulation of phenolic compounds and upregulation of antioxidative enzymes. This study emphasized the significance of morphobiochemical characteristics in rice resistance mechanisms against leaffolder. By leveraging these traits, new resistant rice germplasms against leaffolder can be developed.
Random acoustic noise
Authors: Banek Tadeusz Henryk 
Published: June 2023

Abstract
We introduce the concept of acoustic white noise (AWN) and then we get colored noiseas random sequences generated by dynamic systems (DS) with AWN input. Although DS isvirtual, the noise it generates can mimic real noise. Determining a system that generates agiven noise from white noise is called identification. We solve the task of identification bothfor noise-generating systems and for transmission channels. We also provide estimates for thecapacity of such channels using information theory concepts.
Rapid quantification of alcohol content in intact bottles of wine using J-coupled spectroscopy in an inhomogeneous low field magnet
Authors: Webb Andrew , Najac Chloe , Ronen Itamar 
Published: June 2023

Abstract
Direct spectroscopic quantification of small molecules using low cost, low field (< 0.1 Tesla) large bore portable magnets is not possible using conventional techniques due the presence of strong homonuclear coupling which results in complicated spectral patterns with resonances separated by much less than the achievable spectral linewidth. In contrast, a method using the signals from a Carr-Purcell-Meiboom-Gill (CPMG) train, in which the data are Fourier transformed in this indirect dimension, can produce so-called J-spectra in which several distinct spectral features can be distinguished. In this work we evaluate this technique to quantify the amount of alcohol (ethanol) in intact bottles of wines or spirits.
A case study on oil spills, coastal pollution, and the development of antimicrobial resistance in bacteria isolated from soil collected along the Arabian Sea and Bay of Bengal coastlines
Authors: Rekadwad Bhagwan Narayan , Shouche Yogesh S. , Jangid Kamlesh 
Published: June 2023

Abstract
Pelagic transport causes oil pollution by traversing the open ocean in southern Asia and Indian territory via international tanker routes. The natural flow of ocean water from east to west, which carries pollutants and biohazards into the marine waters belonging to the Indian territory, is what causes the deposition and saturation of oil spills, tar (i.e., hydrocarbons), and wastes in ocean waters. Water currents and tides carry tons of crude oil that has leaked from oil tanker accidents in the open ocean to coastlines. Negative effects such as the formation of algal blooms result in the death of marine animals such as fish, starfish, octopus, squid, and jellyfish. The consequences of pollution have mostly affected coastal areas, especially mangroves, and may destroy potential fishing zones. Long-term exposure to domestic and industrial pollution may be a cause for the loss of biodiversity and the development of antibiotic resistance in bacteria. Microbiological investigations have revealed the presence of hydrocarbon- and antibiotic-resistant bacterial taxa belonging to Bacillus, Domibaciluus, Acinetobacter, Brevundimonas, Streptococcus, Mycolibacterium, Spingomonas, etc. This reveals reasons for pollution in the seas and the development of antimicrobial resistance in microorganisms spreading across coastlines that pose a threat to public health.
Quasi-Static Levitation of Magic Squares
Authors: Fahimi Peyman 
Published: June 2023

Abstract
Magic squares are fascinating mathematical constructs that have captured the imagination of people for centuries. In this study, we investigate the behavior of electrically charged magic squares of order 4 under the influence of electrostatic forces. We treat the matrix elements of the magic squares as electric charges and numerically simulate their behavior using a dynamic controller. Our results demonstrate that the charges move towards a quasi-static equilibrium while preserving the original magic square arrangement and its magical properties. Additionally, the results reveal distinctive patterns in the displacement between the charges. Our study sheds light on the behavior of charged magic squares under electrostatic forces and provides insight into the physical properties of these intriguing mathematical constructs.
Efficient, Green One-Pot Synthesis of Antimicrobial Agents: Functionalized
DPTS Catalyst for the Preparation of 2-Amino-4-Aryl-5-Oxo-4HChromene-
3-Carbonitriles, with Theoretical Calculations
Authors: Beldi Razika , Aimene Nadjet , Barhouchi Badra , Zouchoune Bachir , Boulcina Raouf 
Published: June 2023

Background:
In the search for a new and effective synthetic approach to bio-logically chromene-derived compounds, a series of 2-amino-7, 7-dimethyl-5-oxo-4H-tetrahydrochromene-3-carbonitrile derivatives (4a-i) were synthesized. This synthesis involved the use of 4-(dimethylamino)pyridiniump-toluenesulfonate (DPTS) as a catalyst in an aqueous medium. Additionally, the relative stability between isomers was investigated using DFT/B3LYP calculations.

Methods:
The target compounds were synthesized through a multicomponent reaction of 5,5-dimethyl-1,3-cyclohexanedione (dimedone) 1, various arylaldehydes (2a-i), and malononitrile 3 in water and were recrystallized in ethanol. The reaction was promoted using DPTS, which is a low-toxic, inexpensive, commercially available, and easy-to-handle catalyst.

Results:
The catalytic activity of DPTS was investigated in a condensation reaction conducted in an aqueous medium at room temperature. All synthesized compounds displayed considerable antimicrobial activities against human pathogenic bacteria and fungi.

Conclusion:
The developed synthetic protocol demonstrates energy efficiency, shorter reaction time, environmental friendliness, high product yields with purity, and scalability to gram-scale synthesis. DPTS proved to be a valuable contribution to the field of organocatalysis. The synthesized compounds were screened for in vitro antimicrobial activities, demonstrating varying potency against the microbial strains. Compound 4h exhibited the most potent activity with a zone of inhibition (ZOI) measuring 15 mm against E.coli. This was followed by compounds 4b, 4d, 4f, and 4g, which displayed a ZOI of 12 mm. Furthermore, the antifungal results revealed promising anticandidal activity for compounds 4b, 4e, and 4h, with a lower minimum inhibitory concentration (MIC) of 0.031 mg/ml. In addition, molecular electrostatic potential (MEP) mapping, reactivity indices such as electronegativity, electrophilic index, softness, and hardness, as well as frontier molecular orbitals (HOMO-LUMO), were used to provide further evidence regarding the stability and reactivity of the synthesized products.
A Review and Comprehensive Study on DC-DC Converters
Authors: Anusha Dharavath , P. Srinivasan , K. Narender Reddy 
Published: June 2023

Background:
DC-DC converters are used in various applications based on their required
voltage capabilities ranging from milli volts to thousands of volts.

Methods:
This review paper discusses various voltage boosting techniques, such as buck-boost,
switched inductor, switched capacitors, isolated converters, etc., and provides a detailed evaluation
of the literature and comparison of different DC-DC converters.

Results:
This study reports a number of storage elements included, such as inductors and capacitors
as well as switches and diodes. Their features along with methodologies, merits, complexity,
efficiency, and voltage gain have been tabulated. A comprehensive study, converter classification
based on the characteristics, and a detailed analysis of isolated and non-isolated DC-DC converters
have also been provided.

Conclusion:
As this study provides a comparison of each isolated and non-isolated converter's
comprehensive gain, this research may help in future topology optimization for the choice of the
ideal converter for applications. In addition, the examination of each isolated and non-isolated
converter's comprehensive gain comparison has also been presented in this paper.
Additív gyártástechnológia alkalmazása szélcsatornás szimulációkhoz
Authors: Pálfi Tamás , Ficzere Péter 
Published: June 2023

Napjaink gazdasági szemlélete megköveteli többek között a reoülőgép üzemeltetőktől is, hogy egyre inkább a karbosemlegesség felé szervezzék át működésüket különböző innovatív technológiák bevezetésével.
Jelen tanulmány célja, hogy mely innovatív formájának köszönhetően hozzájárul a repülőgépek üzemanyagfogyasztásának, ezáltal a légszennyezés lecsökkentéséhez.
An Overview of the Situation of SMEs in Hungary in Catching up to Industry 4.0
Authors: Popovicsné Szilágyi Zita 
Published: June 2023

Since I have been working I have been in contact with small and medium-sized enterprises (SMEs) and large companies in various ways. I have thus been confronted with the disadvantages of the former in terms of the introduction and use of 4IF technologies. Yet most of them are aware that to remain competitive in the market, they cannot avoid digitising their operational processes to some extent. I have also found that this mainly depends on the characteristics of the organisation; for example, its orientation. Domestic SMEs are therefore currently at a competitive disadvantage in the market. However, there is no information on whether there is a trend towards development and where they themselves should develop. This would help them to develop the right, achievable vision for the future, coupled with a feasible business strategy.
Depth-social interaction between ethnic in the local culture of Minahasa
Authors: Winoto Darmawan Edi , Dasfordate Aksilas , Pelealu Aldegonda Evangeline , Burdam Yohanes , Ramaino Almen Sulpedi , Dasfordate Gamar 
Published: June 2023

Humans benefit greatly from culture, especially social interaction. Humans' social interaction development will influence connection patterns with the environment. The Minahasa ethnic groups' unity of life grew from the small setting, namely the nuclear and extended family, and subsequently into a village. The social structure based on this relationship type is more inherited. This article explains the Minahasa culture, specifically interaction patterns. The method used is qualitative. Data collection used detailed observation, interviews, and studies bibliography. They use content analysis on reports and examination results from various events in the research area, especially regarding cooperation. The data collected were analyzed qualitatively. Research results show that relationships between family members by genetics or ethnicity are generally close ties. Kinship based on marriage is influential in social life. The market has cooperativeness, friendship, kinship, and patron-client service. In collaboration, the Minahasa and Sanger Talaud ethics are better than the Gorontalo ethics. Ethnic Minahasa and Sangir Talaud have developed many ideas to form harmonious activities between fellow citizens. Cooperation between people from different cultures in Minahasa is quite good in religion. The relationship between religious communities in Minahasa is the mutual respect in their respective worship.
Feasibility and Preliminary Efficacy of Digital Interventions for Depressive Symptoms in Working Adults: Multiarm Randomized Controlled Trial
Authors: Taylor Rachael Wallis , Male Rhian , Economides Marcos , Bolton Heather , Cavanagh Kate 
Published: June 2023

Background
Depressive symptoms are highly prevalent and have broad-ranging negative implications. Digital interventions are increasingly available in the workplace context, but supporting evidence is limited.

Objective
This study aimed to evaluate the feasibility, acceptability, and preliminary efficacy of 3 digital interventions for depressive symptoms in a sample of UK-based working adults experiencing mild to moderate symptoms.

Methods
This was a parallel, multiarm, pilot randomized controlled trial. Participants were allocated to 1 of 3 digital interventions or a waitlist control group and had 3 weeks to complete 6 to 8 short self-guided sessions. The 3 interventions are available on the Unmind mental health app for working adults and draw on behavioral activation, cognitive behavioral therapy, and acceptance and commitment therapy. Web-based assessments were conducted at baseline, postintervention (week 3), and at 1-month follow-up (week 7). Participants were recruited via Prolific, a web-based recruitment platform, and the study was conducted entirely on the web. Feasibility and acceptability were assessed using objective engagement data and self-reported feedback. Efficacy outcomes were assessed using validated self-report measures of mental health and functioning and linear mixed models with intention-to-treat principles.

Results
In total, 2003 individuals were screened for participation, of which 20.22% (405/2003) were randomized. A total of 92% (373/405) of the participants were retained in the study, 97.4% (295/303) initiated their allocated intervention, and 66.3% (201/303) completed all sessions. Moreover, 80.6% (229/284) of the participants rated the quality of their allocated intervention as excellent or good, and 79.6% (226/284) of the participants were satisfied or very satisfied with their intervention. All active groups showed improvements in well-being, functioning, and depressive and anxiety symptoms compared with the control group, which were maintained at 4 weeks. Hedges g effect sizes for depressive symptoms ranged from −0.53 (95% CI −0.25 to −0.81) to −0.74 (95% CI −0.45 to −1.03).

Conclusions
All interventions were feasible and acceptable, and the preliminary efficacy findings indicated that their use may improve depressive symptoms, well-being, and functioning. The predefined criteria for a definitive trial were met.

Trial Registration
International Standard Randomised Controlled Trial Number (ISRCTN) ISRCTN13067492; https://www.isrctn.com/ISRCTN13067492
Strategi pemasaran era new normal di Maca Villas
Authors: Prabhaswara I Ketut Gde Cahdrika , Semara I Made Trisna , Aprinica Ni Putu Isha 
Published: June 2023

Maca Villas & Spa Seminyak harus menemukan strategi baru untuk tetap bertahan dan memenangkan pasar di tengah era new normal yang mengakibatkan perubahan pada segmentasi konsumen. Dalam penelitian ini, peneliti mengedepankan permasalahan mengenai analisa kondisi internal dan eksternal dari Maca Villas & Spa Seminyak saat ini serta menemukan strategi baru yang dapat diaplikasikan kedepannya. Penelitian ini menggunakan analisis SWOT berdasarkan bauran pemasaran 7P, untuk melihat potensi internal dan eksternal Maca Villas & Spa Seminyak, dimana analisis yang digunakan adalah analisis IFAS EFAS, kuadran SWOT, dan matriks SWOT. Dari analisis tersebut didapatkan bahwa Maca Villas & Spa Seminyak terdapat pada kuadran II yaitu Strategi Diversifikasi, dimana hotel ini memiliki keuntungan dari segi kekuatan yang dimiliki tetapi diimbangi dengan ancaman yang tinggi. Hasil dari strategi yang diperoleh, diuji kembali menggunakan analisis QSPM. Strategi utama yang didapatkan dengan skor sebesar 6.76 adalah meningkatkan kinerja Japanese Sales and Marketing serta pengangkatan daily worker apabila diperlukan dalam rangka menyambut bubble travelling yang direncanakan oleh pemerintah.

Maca Villas & Spa Seminyak need to find a new strategy to survive and win the market in the middle of new normal era resulting in changes of consumer segmentation. In this research, researcher put forward the issue of Maca Villas & Spa Seminyak internal and external condition analyze and to find out a new strategic that can be used in the further. This research use SWOT analysis based on marketing mix 7P to see Maca Villas & Spa Seminyak internal and external potential, which the analysis that being used is IFAS EFAS analysis, SWOT quadrant, and SWOT matrix. From the analysis, it was found that Maca Villas & Spa Seminyak is in the 2 nd Quadrant, which Diversification Strategy, where the hotel has advantages in term of strength but balanced with high threat. The strategy is retested by using QSPM analysis. The main strategy got 6.76 point, which is improve the performance of Japanese Sales and Marketing and hire a daily worker if it is needed in order to welcome bubble travelling which is planned by the government.