bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sceptical Agnosticism
Authors: Jonbäck Francis 
Published: March 2023

Abstract
Agnostics as well as theists should answer evidential arguments from evil, at least when confronted with them. In this paper, I answer such an argument by appealing to sceptical agnosticism. A sceptical agnostic is not only undecided about the existence of a perfectly good and omnipotent God, but also believes that we cannot make any judgement about whether or not seemingly gratuitous evil probably is gratuitous. I argue that such agnosticism has several advantages compared with sceptical theism.
Confusion, Understanding and Success
Authors: Belkoniene Miloud 
Published: March 2023

Abstract
The present paper examines a type of sceptical hypothesis put forward by Adam Carter that specifically targets understanding—the Confusion Hypothesis. After clarifying the nature and scope of that hypothesis, it discusses Carter’s favoured virtue perspectivist answer to the challenge it raises. It is argued that this answer is ultimately unsatisfying as it is unable to explain how a subject can obtain assurance that her grasp of a given body of information actually results from the competences she comes to appreciate as being reliable. A different answer that relies on the practical dimension of the specific grasp involved in understanding is then offered and is shown to avoid the problems faced by Virtue Perspectivism.
Differences in Time Perspective in Representatives of Various Generations
Authors: Kot Paweł 
Published: March 2023

Abstract
There are currently five generations: veterans (born 1922–1945), baby boomers (born 1946–1963), generation X (born 1964–1979), generation Y (born 1980–1995) and generation Z (born after 1995). Each person adopts a specific attitude to experiencing the passing of time, i.e., a time perspective. In addition, each person adopts a specific attitude to experiencing the passing time, i.e., a temporal orientation. This study investigates whether members of different generations differ in of terms of their preferred time perspective. The Zimbardo Time Perspective Inventory was used in the study. A total of 435 people were surveyed, out of which 215 (49.4%) were women and 220 (50.6%) men. The subjects were aged 16–81, and the average age for the whole group was M = 45.04, SD = 19.20. The conducted analyses revealed the occurrence of statistically significant differences between generations X, Y, Z and between veterans and baby boomers. In the groups of veterans and baby boomers, the highest intensity was demonstrated for the past positive perspective. Among members of generations X and Y, future perspective was the most preferred one. In generation Z, the hedonistic present and the positive past are the most strongly preferred time perspective. The obtained results can be used in the work with individual generations in order to develop more adaptive profiles of time perspective. This applies in particular to generation Z, which seems to represent the least functional time perspective.
Is There an Alternative to Consensus? The Impact of the 2014 Coalition Deal on Voting Behaviour in the Eighth European Parliament (2014–2019)
Authors: Costa Olivier , Marié Awenig 
Published: March 2023

Abstract
Consensus is a key feature of the European Union. In the European Parliament, most legislation is adopted by a grand coalition between the left and the right. While this trans-partisan cooperation has always been informal, the epp and s&d groups agreed on a formal political coalition in 2014. For the first time in the ep’s history, this grand coalition was based on a policy programme negotiated by the two groups’ leadership. Based on roll-call vote data, this paper aims to understand the impact of this deal on actual coalition-building in the ep plenary. We find that the 2014 coalition deal provided a framework that incentivises legislative actors to increase their levels of cooperation on the issues on which they usually cooperate the least.
The burden of disease due to COVID-19 in Sweden 2020–2021: A disability-adjusted life years (DALYs) study
Authors: Shedrawy Jad , Ernst Patricia , Lönnroth Knut , Nyberg Fredrik 
Published: March 2023

Background: The burden of COVID-19 disease can be measured in terms of disability-adjusted life years (DALYs), which is composed of two components: the years of life lost through premature death (YLL) and the number of years lived with disability (YLD), adjusted for level of disability. This study measured DALYs due to COVID-19 in Sweden and compared it to the burden of other diseases. Methods: The methodology used in the calculation of DALYs was based on the Global Burden of Disease guidelines. The number of patients diagnosed with mild/moderate, severe or critical COVID-19 and/or post-COVID-19 condition between March 2020 and October 2021 was extracted from national registries and used for YLD calculations. In addition, the numbers of death due to COVID-19 in different age groups were used for the YLL calculation. Results: During the study period, 152,877 DALYs were lost to COVID-19 in Sweden, 99.3% of which was attributed to YLL. Loss of DALYs occurred mainly among the elderly, with 66.8% of DALYs attributed to individuals >70 years old. Compared to other diseases, the burden of COVID-19 in 2020 ranked as the eighth leading cause of DALY lost. Conclusions: Similar to other countries, the burden of COVID-19 in Sweden was concentrated mainly among the elderly, who contributed most of the DALY lost due to premature mortality. Yet, DALY loss remained lower for COVID-19 than for several other diseases. The contribution of YLD to DALYs lost was minimal. However empirical data on the occurrence and disability of post-COVID-19 condition are scarce, and YLD may therefore be underestimated.
Improved electrical properties of micro light-emitting diode displays by ion implantation technology
Authors: Hsu Yu-Hsuan , Wang Chi-Han , Lin Xin-Dai , Lin Yi-Hsin , Wuu Dong-Sing , Horng Ray-Hua 
Published: March 2023

AbstractGenerally, the inductively coupled plasma-reactive ion etching (ICP-RIE) mesa technology was used to remove p-GaN/MQWs and expose n-GaN for electrical contact in a fabricated micro light-emitting diode (μLED). In this process, the exposed sidewalls were significantly damaged which result in small-sized μLED presenting a strong size-dependent influence. Lower emission intensity was observed in the μLED chip, which can be attributed to the effect of sidewall defect during etch processing. To reduce the non-radiative recombination, the ion implantation using an As+ source to substitute the ICP-RIE mesa process was introduced in this study. The ion implantation technology was used to isolate each chip to achieve the mesa process in the μLED fabrication. Finally, the As+ implant energy was optimized at 40 keV, which exhibited excellent current–voltage characteristics, including low forward voltage (3.2 V @1 mA) and low leakage current (10–9 A@− 5 V) of InGaN blue μLEDs. The gradual multi-energy implantation process from 10 to 40 keV can further improve the electrical properties (3.1 V @1 mA) of μLEDs, and the leakage current was also maintained at 10–9 A@− 5 V.
A web tool for the global identification of pig breeds
Authors: Miao Jian , Chen Zitao , Zhang Zhenyang , Wang Zhen , Wang Qishan , Zhang Zhe , Pan Yuchun 
Published: March 2023

Abstract
Background
Natural and artificial selection for more than 9000 years have led to a variety of domestic pig breeds. Accurate identification of pig breeds is important for breed conservation, sustainable breeding, pork traceability, and local resource registration.

Results
We evaluated the performance of four selectors and six classifiers for breed identification using a wide range of pig breeds (N = 91). The internal cross-validation and external independent testing showed that partial least squares regression (PLSR) was the most effective selector and partial least squares-discriminant analysis (PLS-DA) was the most powerful classifier for breed identification among many breeds. Five-fold cross-validation indicated that using PLSR as the selector and PLS-DA as the classifier to discriminate 91 pig breeds yielded 98.4% accuracy with only 3K single nucleotide polymorphisms (SNPs). We also constructed a reference dataset with 124 pig breeds and used it to develop the web tool iDIGs (http://alphaindex.zju.edu.cn/iDIGs_en/) as a comprehensive application for global pig breed identification. iDIGs allows users to (1) identify pig breeds without a reference population and (2) design small panels to discriminate several specific pig breeds.

Conclusions
In this study, we proved that breed identification among a wide range of pig breeds is feasible and we developed a web tool for such pig breed identification.
Validation of the questionnaire for medical checkup of old-old (QMCOO) score cutoff to diagnose frailty
Authors: Yakabe Mitsutaka , Shibasaki Koji , Hosoi Tatsuya , Matsumoto Shoya , Hoshi Kazuhiro , Akishita Masahiro , Ogawa Sumito 
Published: March 2023

Abstract
Background
Frailty is a state of increased vulnerability to poor resolution of homeostasis following a stress. Early diagnosis and intervention of frailty are essential to prevent its adverse outcomes. However, simple diagnostic criteria have not been established. The Questionnaire for Medical Checkup of Old-Old (QMCOO) is widely used for medical checkups of older adults in Japan. In our previous report, we developed a method to score the QMCOO and showed that frailty can be diagnosed with the highest accuracy when the score cutoff was set at 3/4 points. We aimed to validate the criteria in a larger cohort.

Methods
Participants aged 65 years or over were recruited in the western region of Japan. They answered all the items of the Kihon Checklist (KCL) and the QMCOO. Based on the KCL score, they were diagnosed as robust (3 or lower), prefrail (4 to 7), or frail (8 or over). Then we tested the effectiveness to diagnose frailty using the QMCOO cutoff of 3/4 points. We also aimed to determine the score cutoff to separate robust and prefrail.

Results
7,605 participants (3,458 males and 4,147 females, age 77.4 ± 6.9 years) were recruited. 3,665 participants were diagnosed as robust, 2,448 were prefrail, and 1,492 were frail based on the KCL score. The diagnosis of frailty had a sensitivity of 84.0%, specificity of 82.5%, and accuracy of 82.8% with a QMCOO score cutoff of 3/4 points, suggesting its validity. To separate robust and prefrail, both the accuracy and the Youden index were the highest with the QMCOO cutoff of 2/3 points (sensitivity, specificity, and accuracy were 63.9%, 83.4%, and 75.6%, respectively). All the questions of the QMCOO except Q12 (about smoking) were significantly related to prefrailty status after a logistic regression analysis.

Conclusion
Diagnosis of frailty using the QMCOO score cutoff of 3/4 points was validated. Prefrailty could be diagnosed using the score cutoff of 2/3 points.
Women’s experiences of trauma, the psychosocial impact and health service needs during the perinatal period
Authors: Perera Essence , Chou Sharon , Cousins Nicole , Mota Natalie , Reynolds Kristin 
Published: March 2023

Abstract
Background
Traumatic events are associated with psychological and physical health problems for women in the perinatal period (i.e., pregnancy-12-months after childbirth). Despite the negative impact of trauma on perinatal women, the long-term impact of such diverse trauma and women’s experience during the perinatal period remains understudied.

Methods
This study explored two research questions: 1) What are the psychological experiences of perinatal women who have experienced interpersonal traumatic events? And 2) What are the service needs and gaps expressed by women relating to perinatal medical protocols and psychological services? These questions were addressed via in-depth semi-structured qualitative interviews with nine perinatal women (one pregnant and eight postpartum) residing in central Canada who reported experiencing interpersonal traumatic events occurring from adolescence to the perinatal period. Recruitment and data collection occurred from October 2020 to June 2021. Interviews were audio-recorded, transcribed, and analyzed according to constructivist grounded theory.

Results
The emergent grounded theory model revealed the central theme of the role of prior trauma in shaping women’s perinatal experiences, with four related main themes including perinatal experiences during the COVID-19 pandemic, the role of social support in women’s perinatal experiences, the barriers that women experienced while seeking psychological and medical services prior to the perinatal period and during the perinatal period, and the specific needs of perinatal women with a history of interpersonal trauma.

Conclusions
Findings of this research highlight the negative and long-lasting impact of traumatic events experienced on women’s psychological health and psychosocial functioning during the perinatal period, as well as perinatal women’s unmet psychological and medical service needs. A call to action for perinatal researchers and clinicians is imperative in furthering this important area of research and practicing person-centered and trauma-informed care with this population.
Radiomics nomogram for preoperative differentiation of pulmonary mucinous adenocarcinoma from tuberculoma in solitary pulmonary solid nodules
Authors: Zhang Junjie , Hao Ligang , Qi MingWei , Xu Qian , Zhang Ning , Feng Hui , Shi Gaofeng 
Published: March 2023

Abstract
Objective
To develop and validate predictive models using clinical parameters, radiomic features and a combination of both for preoperative differentiation of pulmonary nodular mucinous adenocarcinoma (PNMA) from pulmonary tuberculoma (PTB).

Method
A total of 124 and 53 patients with PNMA and PTB, respectively, were retrospectively analyzed from January 2017 to November 2022 in The Fourth Affiliated Hospital of Hebei Medical University (Ligang et al., A machine learning model based on CT and clinical features to distinguish pulmonary nodular mucinous adenocarcinoma from tuberculoma, 2023). A total of 1037 radiomic features were extracted from contrast-enhanced computed tomography (CT). The patients were randomly divided into a training group and a test group at a ratio of 7:3. The least absolute shrinkage and selection operator (LASSO) algorithm was used for radiomic feature selection. Three radiomics prediction models were applied: logistic regression (LR), support vector machine (SVM) and random forest (RF). The best performing model was adopted, and the radiomics score (Radscore) was then computed. The clinical model was developed using logistic regression. Finally, a combined model was established based on clinical factors and radiomics features. We externally validated the three models in a group of 68 patients (46 and 22 patients with PNMA and PTB, respectively) from Xing Tai People’s Hospital (30 and 14 patients with PNMA and PTB, respectively) and The First Hospital of Xing Tai (16 and 8 patients with PNMA and PTB, respectively). The area under the receiver operating characteristic (ROC) curve (AUC) value and decision curve analysis were used to evaluate the predictive value of the developed models.

Results
The combined model established by the logistic regression method had the best performance. The ROC-AUC (also a decision curve analysis) of the combined model was 0.940, 0.990 and 0.960 in the training group, test group and external validation group, respectively, and the combined model showed good predictive performance for the differentiation of PNMA from PTB. The Brier scores of the combined model were 0.132 and 0.068 in the training group and test group, respectively.

Conclusion
The combined model incorporating radiomics features and clinical parameters may have potential value for the preoperative differentiation of PNMA from PTB.
Bronchial tuberculosis with recurrent spontaneous pneumothorax: A case report
Authors: Li Ting , Li Yu-hong , Zhang Ming 
Published: March 2023

Abstract
Background
Spontaneous pneumothorax associated with tuberculosis due to clinical manifestations, imaging findings and negative pleural biopsy is rare.

Case report
A 43-year-old young woman went to the hospital several times because of recurrent dyspnea and was diagnosed with a right spontaneous pneumothorax. She underwent multiple closed thoracic drainage procedures, but the pneumothorax was not completely resolved. Pleural biopsy pathology was chronic inflammation; there was no evidence of tuberculosis. A small amount of pneumothorax persisted, intermittent dyspnea became more severe, and pneumothorax increased. Bronchoscopy showed thickening of the left lung lingular segment mucosa, and the bronchial lavage fluid gene X-PERT/rifampicin resistance test was positive. After one month of anti-tuberculosis treatment, the symptoms of short breath were completely relieved, and chest computerized tomography (CT) showed complete resolution of the right pneumothorax.

Conclusions
When searching for the cause of spontaneous pneumothorax, people should not overlook tuberculosis-related secondary pneumothorax, which should be diagnosed and treated as soon as possible.
Roles of tumor-associated macrophages in anti-PD-1/PD-L1 immunotherapy for solid cancers
Authors: Zhang Hao , Liu Lin , Liu Jinbo , Dang Pengyuan , Hu Shengyun , Yuan Weitang , Sun Zhenqiang , Liu Yang , Wang Chengzeng 
Published: March 2023

AbstractIn recent years, tumor immunotherapy has made significant progress. However, tumor immunotherapy, particularly immune checkpoint inhibitors (e.g., PD-1/PD-L1 inhibitors), benefits only a tiny proportion of patients in solid cancers. The tumor microenvironment (TME) acts a significant role in tumor immunotherapy. Studies reported that tumor-associated macrophages (TAMs), as one of the main components of TME, seriously affected the therapeutic effect of PD-1/PD-L1 inhibitors. In this review, we analyzed TAMs from epigenetic and single-cell perspectives and introduced the role and mechanisms of TAMs in anti-programmed death protein 1(anti-PD-1) therapy. In addition, we summarized combination regimens that enhance the efficacy of tumor PD-1/PD-L1 inhibitors and elaborated on the role of the TAMs in different solid cancers. Eventually, the clinical value of TAMs by influencing the therapeutic effect of tumor PD-1/PD-L1 inhibitors was discussed. These above are beneficial to elucidate poor therapeutic effect of PD-1/PD-L1 inhibitors in solid tumors from the point of view of TAMs and explore the strategies to improve its objective remission rate of solid cancers.
Cord blood presepsin as a predictor of early-onset neonatal sepsis in term and preterm newborns
Authors: Priolo Francesca , Maggio Luca , Fattore Simona , Tedesco Marta , De Rose Domenico Umberto , Perri Alessandro , Prontera Giorgia , Chioma Roberto , Sbordone Annamaria , Patti Maria Letizia , Vento Giovanni 
Published: March 2023

Abstract
Background
To date, no studies on presepsin values in cord blood of term infants with risk factors for early-onset sepsis (EOS) are available, whereas only one study reported presepsin values in cord blood of preterm infants at risk. In this study, we investigated the presepsin values in cord blood of term and preterm infants with documented risk factors for EOS.

Methods
In this single-center prospective pilot study, we enrolled neonates presenting with documented risk factors for EOS. P-SEP levels were assessed in a blood sample collected from the clamped umbilical cord after the delivery in 93 neonates, using a point-of-care device. The primary outcome of our study was to evaluate the role of cord blood P-SEP in predicting clinical EOS in term and preterm infants.

Results
During the study period, we enrolled 93 neonates with risk factors for EOS with a gestational age ranging between 24.6 and 41.6 weeks (median 38.0). The median P-SEP value in all infants was 491 pg/ml (IQR 377 – 729). Median cord P-SEP values were significantly higher in infants with clinical sepsis (909 pg/ml, IQR 586 – 1307) rather than in infants without (467 pg/ml, IQR 369 – 635) (p = 0.010). We found a statistically significant correlation between cord P-SEP value at birth and the later diagnosis of clinical sepsis (Kendall's τ coefficient 0.222, p = 0.002). We identified the maximum Youden’s Index (best cut-off point) at 579 pg/ml, corresponding to a sensitivity of 87.5% and a specificity of 71.8% in predicting clinical sepsis.

Conclusions
Maximum Youden’s index was 579 pg/ml for clinical EOS using cord P-SEP values. This could be the starting point to realize multicenter studies, confirming the feasibility of dosing P-SEP in cord blood of infants with risk factors of EOS to discriminate those who could develop clinical sepsis and spare the inappropriate use of antibiotics.
Association of cortical and subcortical microstructure with disease severity: impact on cognitive decline and language impairments in frontotemporal lobar degeneration
Authors: Ding Wencai , Ren Peng , Yi Liye , Si Yao , Yang Fan , Li Zhipeng , Bao Hongbo , Yan Shi , Zhang Xinyu , Li Siyang , Liang Xia , Yao Lifen ,   for the Frontotemporal Lobar Degeneration Neuroimaging Initiative, Rosen Howard , Dickerson Bradford C. , Domoto-Reilly Kimoko , Knopman David , Boeve Bradley F. , Boxer Adam L. , Kornak John , Miller Bruce L. , Seeley William W. , Gorno-Tempini Maria-Luisa , McGinnis Scott , Mandelli Maria Luisa 
Published: March 2023

Abstract
Background
Cortical and subcortical microstructural modifications are critical to understanding the pathogenic changes in frontotemporal lobar degeneration (FTLD) subtypes. In this study, we investigated cortical and subcortical microstructure underlying cognitive and language impairments across behavioral variant of frontotemporal dementia (bvFTD), semantic variant of primary progressive aphasia (svPPA), and nonfluent variant of primary progressive aphasia (nfvPPA) subtypes.

Methods
The current study characterized 170 individuals with 3 T MRI structural and diffusion-weighted imaging sequences as portion of the Frontotemporal Lobar Degeneration Neuroimaging Initiative study: 41 bvFTD, 35 nfvPPA, 34 svPPA, and 60 age-matched cognitively unimpaired controls. To determine the severity of the disease, clinical dementia rating plus national Alzheimer’s coordinating center behavior and language domains sum of boxes scores were used; other clinical measures, including the Boston naming test and verbal fluency test, were also evaluated. We computed surface-based cortical thickness and cortical and subcortical microstructural metrics using tract-based spatial statistics and explored their relationships with clinical and cognitive assessments.

Results
Compared with controls, those with FTLD showed substantial cortical mean diffusivity alterations extending outside the regions with cortical thinning. Tract-based spatial statistics revealed that anomalies in subcortical white matter diffusion were widely distributed across the frontotemporal and parietal areas. Patients with bvFTD, nfvPPA, and svPPA exhibited distinct patterns of cortical and subcortical microstructural abnormalities, which appeared to correlate with disease severity, and separate dimensions of language functions.

Conclusions
Our findings imply that cortical and subcortical microstructures may serve as sensitive biomarkers for the investigation of neurodegeneration-associated microstructural alterations in FTLD subtypes.

Graphical Abstract
Flowchart of the study design (see materials and methods for detailed description).