bluuebunny/crossref_metadata_2025_split huggingface dataset:
Alternative approaches to clinical electrophysiology
Authors: Ippolitova T. , Lukashin A. , Veberg A. 
Published: January 2023

Purpose: Creation of a device and a new methodology for registering an electrocardiogram that does not require fixation of dogs and impose electrodes.Materials and methods. Two groups have formed that included clinically healthy 12 dogs of small breeds with a weight category of 10 kg, age restrictions were from 3 to 5 years. Electrocardiograms were recorded as a standard veterinary electrocardiogram, so on the CONAN hardware and software, using standard I, II, III ECG of lead. Electrodes "Crocodile" were fixed on the skin of the pelvic folds, the skin near the elbow joint. The second stage of the study was based on the creation of a contact platform capable of registering a nervous impulse. The proposed methodology for registering electrophysiological activity of the heart is based on the creation of mycal electrodes that can perceive indications in the position of the studied animal standing, excluding a stressful effect, lowering the degree of excitation. The third stage of the study was to register an electrocardiogram through a contact site, followed by assessment and comparison with classical methods.Results. In the testimony of atrial and ventricular complexes, when using both methods, there were no differences. The amplitude is preserved, the distance between the intervals did not change. During the observation, the lack of pronounced excitement in dogs was revealed when using the simulated site, which, in turn, facilitates the interpretation procedure. The observation revealed a reduction in the time spent on research when using an experimental methodology.
Linee evolutive del ruolo dei laici nel diritto canonico vigente
Authors: Caprara Leonardo 
Published: January 2023

Il Concilio Vaticano II costituisce lo spartiacque storico tra due epoche: quella preconciliare dominata dalla visione della Chiesa come societas perfecta inæqualis e dalla conseguente costruzione del rapporto laico/chierico in termini di subordinazione/sovraordinazione e quella post-conciliare nella quale matura l’idea della corresponsabilità e partecipazione di tutti i battezzati - siano essi chierici, laici o religiosi - nell’edificazione del Corpo di Cristo. Gli apporti della dottrina conciliare sono stati trasfusi in termini giuridici nel Codex del 1983 che pone al centro del (nuovo) diritto costituzionale canonico il principio di uguaglianza specificato dal principio di varietà: tutti i fedeli sono eguali nella dignità e nell’azione godendo dei medesimi diritti e doveri ma ognuno di essi è chiamato a partecipare alla missione della Chiesa con uno specifico ruolo determinato dalla rispettiva vocazione e condizione. Dopo aver dato conto del mutamento di indirizzo tra il Codice del 1917 e la nuova codificazione canonica, il presente contributo si sofferma sull’evoluzione della concezione del laicato nel post- Concilio con particolare attenzione ad alcuni documenti pubblicati nel corso degli ultimi tre pontificati sottolineandosene il contributo decisivo sia quanto all’interpretazione, arricchimento e sviluppo dei principi conciliari sia quanto all’applicazione concreta delle norme codiciali.
Efficacy and safety of CounterFlow in animal models of hemorrhage
Authors: Peng Nuoya , Yeh Han H. , Khavari Adele , Zhang-Gao Han , Tenn Catherine , Semple Hugh A. , Cau Massimo F. , Beckett Andrew , Kastrup Christian J. 
Published: January 2023

LAY SUMMARY The efficacy of current hemostatic technologies is limited by several factors. Outward blood flow washes hemostatic drugs away from the wound, and hemostatic drugs often require focus, training, and time to use correctly, are highly specific to one type of injury, or pose severe safety risks. CounterFlow is a novel product that could potentially save military and civilian lives by stopping heavy bleeding from a variety of organs and other bodily locations that current technology cannot easily treat. Upon contact with blood, CounterFlow releases bursts of gas to safely self-propel bio-degradable clot-forming and clot-stabilizing drugs against blood flow, delivering them to the source of bleeding. This unique mechanism allows CounterFlow to be applied quickly to a wide assortment of wounds and to act effectively with little management after application. CounterFlow was tested in multiple animal models representing common and deadly bleeding scenarios, including internal bleeding, care under fire without compression, and surgical bleeding, and it was found to outperform current care options by stopping bleeds faster and increasing survival times. CounterFlow is also safe to use and biocompatible. This narrative review summarizes studies testing the effectiveness and safety of CounterFlow, discusses useful applications, and describes future plans for the product.
Association of persistent respiratory symptoms with severity of COVID-19
Authors: Rahman Mohammed Mirazur , Habib Farjana Binte , Kabir Ahmed Imran , Jahan Rawnak , Rahman Samia , Sarkar Shish Mohammad , Bhowmik Ratan Chandra , Hossain AKM Mosharraf 
Published: January 2023

Background: Coronavirus disease 2019 (COVID-19) is a new and highly contagious respiratory disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Symptoms and disease severity of COVID-19 vary from asymptomatic to severe or fatal illness. A major complication of those who survived from COVID-19 is the development of lung disease leading to persistence of respiratory symptoms. The objective of the present study was to find out the association of persistence of respiratory symptoms with severity of COVID-19.
Methods: This prospective observational study was carried out in the Department of Respiratory Medicine, Bangabandhu Sheikh Mujib Medical University, Dhaka during the period from July 2020 to December 2020. During follow-up around three months (90.62±2.21 days) after the onset of the first COVID-19 symptoms, 500 patients were taken as the study sample.
Results: Total patients were 500 with 206 (41.2%) severe cases. Two-fifths of the study participants had persistent respiratory symptom at 3 months. Persistence of respiratory symptoms was associated with severity of COVID-19 (p = <0.001). Among the respiratory symptoms, shortness of breath (34.72%) and cough (29.63%) were the most prevalent symptoms that was persisted in severe COVID-19 during follow-up.
Conclusion: This study has shown that persistent respiratory symptoms were common after COVID-19 that was about 40% and were associated with the severity of COVID-19.
BIRDEM Med J 2023; 13(1): 16-21
A case of premature aging with recurrent pancreatitis and lipodystrophy
Authors: Dutta Mita , Tabassum Maliha , Islam Mohammad Aminul , Hossain Kazi Nazmul , Afsana Faria , Amin Mohammod Feroz , Pathan Md Faruque , Pathan Md Faruque 
Published: January 2023

Werner’s syndrome (WS) is characterized by insulin resistance along with signs of premature aging. It poses great diagnostic challenge because of its unusual presentation. We describe a case of WS in a 30-year-old female, who presented with recurrent pancreatitis and documented hypertriglyceridemia along with hyperglycemia despite getting more than 200 units of insulin per day, without any history of hyperglycemic emergency such as diabetic ketoacidosis (DKA)/ hyperglycemic hyperosmolar state (HHS). Examination showed signs of premature aging (alopecia, progressive sharpening of facial features, loss of upper incisor teeth, wrinkles and freckles) and generalized wasting. Scalp biopsy confirmed the diagnosis.
BIRDEM Med J 2023; 13(1): 56-59
Desenvolvimento e validação de aplicativo web para gestão em fisioterapia na área de traumato-ortopedia
Authors: Cardoso Náthila Lorrana Silva , Costa Cristiane de Fátima Pimenta da , Rodrigues João Rebertt Silva Prado , Azevedo Miguel Itallo Bentes de , Guimarães Andrea de Cassia Lima , Aviz Leonardo Breno do Nascimento de , Dias Biatriz Araújo Cardoso , Dias George Alberto da Silva 
Published: January 2023

Devido os avanços da tecnologia em todos os âmbitos, houve a introdução de recursos tecnológicos como meios facilitadores na área da saúde. Com isso, neste estudo objetivou-se desenvolver e validar um aplicativo web para gestão em fisioterapia na área de traumato-ortopedia. Trata-se de um estudo metodológico de produção e validação de tecnologia de cunho assistencial e educacional, realizado entre outubro de 2021 e novembro de 2022, na Universidade do Estado do Pará, por meio de 4 fases: diagnóstico situacional, revisão da literatura, formulação e montagem do aplicativo web e sua validação. O desenvolvimento do app seguiu com duas etapas técnicas, o Front-end e o back-end. Já a etapa de validação de conteúdo com os juízes especialistas foi realizada por meio de um instrumento validado, o qual é dividido em duas partes, a primeira com informações sobre os juízes-especialistas e a segunda com 22 questões referentes a tecnologia apresentada. Participaram da pesquisa 9 Fisioterapeutas, com média do tempo de formação de 21,00±6,38 anos. Na primeira e única rodada de validação, observou-se um Índice de Validade de Conteúdo (IVC) de 0,96 para o bloco de objetivos, 0,99 para o bloco de estrutura e apresentação, e 0,96 para o bloco de relevância, com um IVC geral de 0,97, sendo considerado estatisticamente válido. Conclui-se que o aplicativo web revelou-se um dispositivo válido e adequado para ser disponibilizado aos fisioterapeutas atuantes em traumato-ortopedia, podendo trazer benefícios em diversos aspectos.
Cardiotocography analysis by empirical dynamic modeling and Gaussian processes
Authors: Feng Guanchao , Heiselman Cassandra , Quirk J. Gerald , Djurić Petar M. 
Published: January 2023

Introduction:During labor, fetal heart rate (FHR) and uterine activity (UA) can be continuously monitored using Cardiotocography (CTG). This is the most widely adopted approach for electronic fetal monitoring in hospitals. Both FHR and UA recordings are evaluated by obstetricians for assessing fetal well-being. Due to the complex and noisy nature of these recordings, the evaluation by obstetricians suffers from high interobserver and intraobserver variability. Machine learning is a field that has seen unprecedented advances in the past two decades and many efforts have been made in computerized analysis of CTG using machine learning methods. However, in the literature, the focus is often only on FHR signals unlike in evaluations performed by obstetricians where the UA signals are also taken into account.Methods:Machine learning is a field that has seen unprecedented advances in the past two decades and many efforts have been made in computerized analysis of CTG using machine learning methods. However, in the literature, the focus is often only on FHR signals unlike in evaluations performed by obstetricians where the UA signals are also taken into account. In this paper, we propose to model intrapartum CTG recordings from a dynamical system perspective using empirical dynamic modeling with Gaussian processes, which is a Bayesian nonparametric approach for estimation of functions.Results and Discussion:In the context of our paper, Gaussian processes are capable for simultaneous estimation of the dimensionality of attractor manifolds and reconstructing of attractor manifolds from time series data. This capacity of Gaussian processes allows for revealing causal relationships between the studied time series. Experimental results on real CTG recordings show that FHR and UA signals are causally related. More importantly, this causal relationship and estimated attractor manifolds can be exploited for several important applications in computerized analysis of CTG recordings including estimating missing FHR samples, recovering burst errors in FHR tracings and characterizing the interactions between FHR and UA signals.
DEB-TACE with irinotecan versus C-TACE for unresectable intrahepatic cholangiocarcinoma: a prospective clinical study
Authors: Wang Junxiao , Xue Yaoqin , Liu Rui , Wen Zhenyu , Ma Zhenhu , Yang Xiang , Yu Lingxiang , Yang Bin , Xie Hui 
Published: January 2023

Objectives: DEB-TACE with irinotecan and C-TACE were compared with regards to safety and efficacy for the therapy of intrahepatic cholangiocarcinoma (ICC).Methods: Institutional Review Board approved our trial and we registered it in the Chinese Clinical Trial Registry (ChiCTR1900022856). Forty patients with biopsy-confirmed ICC were randomised to either receive DEB-TACE or C-TACE treatment with 20 patients in each treatment arm. The primary endpoints objective response rate (ORR) and progression free survival (PFS) using the mRECIST to evaluate the tumours. The secondary endpoints were overall survival (OS) and safety. The chi-square was used to analyse the data. The Kaplan-Meier method and Cox analysis were used to evaluate the survival data.Results: ORR (70% in DEB-TACE group vs. 20% in C-TACE, p = .001) at 1 month after therapy, ORR (50% vs. 15%, p = .018) at 3 months and DCR (70% vs. 30%, p = .011) at 6 months, while no difference was found in other groups. (all p &gt; .05) The median PFS with DEB-TACE was longer than that with C-TACE (8.0 months vs. 3.0 months) (p = .042). Although the median OS was longer with DEB-TACE than with C-TACE (11.5 months vs. 9.0 months), the difference was not statistically significant (p = .280). The Cox regression analysis demonstrated that TACE sessions (p = .017) and low CA125 levels (p = .001) were independent favourable prognostic factors. The most frequent adverse event was elevated transaminase levels (20/20 in DEB-TACE group vs. 15/20 in C-TACE group) (p = .047).Conclusion: Our prospective study suggested better ORR and PFS with DEB-TACE with irinotecan as compared to C-TACE with irinotecan in the treatment of unresectable ICC.
Cell Cluster Sorting in Automated Differentiation of Patient-specific Induced Pluripotent Stem Cells Towards Blood Cells
Authors: Ma Zhiyao , Toledo Marcelo Augusto Szymanskide , Wanek Paul , Elsafi Mabrouk Mohamed H. , Smet Francis , Pulak Rock , Pieske Simon , Piotrowski Tobias , Herfs Werner , Brecher Christian , Schmitt Robert H. , Wagner Wolfgang , Zenke Martin 
Published: January 2023

Graphical AbstractClonal iPS cell lines and embryoid bodies (EB) of defined size are obtained by cell cluster sorting in an automated platform.
Low-intensity continuous ultrasound to inhibit cancer cell migration
Authors: González Itziar , Luzuriaga Jon , Valdivieso Alba , Candil Manuel , Frutos Jesús , López Jaime , Hernández Luis , Rodríguez-Lorenzo Luis , Yagüe Virginia , Blanco Jose Luis , Pinto Alberto , Earl Julie 
Published: January 2023

In recent years, it has been verified that collective cell migration is a fundamental step in tumor spreading and metastatic processes. In this paper, we demonstrate for the first time how low-intensity ultrasound produces long-term inhibition of collective migration of epithelial cancer cells in wound healing processes. In particular, we show how pancreatic tumor cells, PANC-1, grown as monolayers in vitro respond to these waves at frequencies close to 1 MHz and low intensities (&lt;100 mW cm−2) for 48–72 h of culture after some minutes of a single ultrasound irradiation. This new strategy opens a new line of action to block the spread of malignant cells in cancer processes. Despite relevant spatial variations of the acoustic pressure amplitude induced in the assay, the cells behave as a whole, showing a collective dynamic response to acoustic performance. Experiments carried out with samples without previous starving showed remarkable effects of the LICUs from the first hours of culture, more prominent than those with experiments with monolayers subjected to fasting prior to the experiments. This new strategy to control cell migration demonstrating the effectiveness of LICUS on not starved cells opens a new line of action to study effects of in vivo ultrasonic actuation on tumor tissues with malignant cells. This is a proof-of-concept study to demonstrate the physical effects of ultrasound stimulation on tumor cell migration. An in-depth biological study of the effects of ultrasounds and underlying biological mechanisms is on-going but out of the scope of this article.
Serum D-dimer is not predictive of placenta-mediated complications in pregnancy at high risk: The multicentric prospective cohort AngioPred study
Authors: Hovine Agathe , Chauleur Céline , Gauld Christophe , Rancon Florence , Gris Jean-Christophe , Tardy Brigitte , Giraud Antoine , Raia-Barjat Tiphaine 
Published: January 2023

Background: The theory that D-dimer level might has a predictive or diagnostic role in preeclampsia needs to be explored. Aim of the study was to evaluate the association between serum D-dimer level and the occurrence of placenta-mediated complications (PMC) in a pregnant population at high risk.Methods: A prospective multicenter cohort study including 200 pregnant women was conducted.Results: Serum D-dimer increases throughout pregnancy, with the highest levels at the end of gestation. Serum D-dimer level was similar for women with PMC and with no complication. Serum D-dimer level was not different in women with preeclampsia versus uncomplicated women. Serum D-dimer level was not different in women with early or late preeclampsia versus uncomplicated women.Conclusion: This result suggests that serum D-dimer level was not predictive of the PMC occurrence. This corroborates the fact that the origin of PMC based more on immunity than in hemostasis.
Gender and disruptions in family routines and stress amid COVID-19
Authors: Saxena Mamta , Shedlock Dorothy J. , Gold Zachary S. 
Published: January 2023

BackgroundFamily scientists strongly purport that structured family routines are associated with family stability and identity and may mediate the individuals' positive developmental outcomes. Family routines enhance the predictability of ambiguous situations, promote members' cohesion, and provide security and warmth. Investigating adverse changes in family routines during COVID-19 can inform on support required by families from other larger systemic institutions.Theoretical backgroundHistorically, family routines have universally been a gendered realm, and the contributions of females have been salient in maintaining them. Established and gendered contributions pre-COVID-19 predicted who does what and how much in the household. After the spread of COVID-19, the gendered practice continued and, in many households, strengthened. Therefore, exploration of proximal processes in the microsystem, such as family routines through the Bioecological perspectives, may offer insights into the historical rationale and repercussions of the gendered division of household labor on individual family members, especially women, and in times of crisis, such as a pandemic.Purpose and methodThe health implications of COVID-19 led to restrictive mandates, including remote employment and education directives resulting in additional stress and uncertainty in carrying out daily routines. Thus, there is a need to explore whether restrictive mandates during COVID-19 changed specific family routines and gender outcomes. In the current study, we surveyed (online) 378 adult participants about changes (disruptions) in their family routines, perceptions of disruptions in routines, and perceived stress levels. The research questions are:(1) Does participants' gender continue to determine specific family routines?(2) What are participants' perceptions of disruptions in family routines, and do those responses to family routines differ significantly by participants' gender?(3) Are there significant gender differences in perceptions of stress among participants?Findings and conclusionsData analyses indicated that during COVID-19, both males and females were equally affected by changes in routines and had similar perceptions of disruptions and high-stress levels. However, item-level analyses indicate that females significantly spent more time on chores that would benefit others, whereas male participants spent more time on routines that would benefit them. Both males and females reported high-stress levels but differed in symptomatology. We provide a few selected narratives to supplement gender-based quantitative findings and establish descriptive evidence for differences in disruptions in routines and stress. In the end, implications for future practice and research are discussed.
A study on the prevalence and related factors of frailty and pre-frailty in the older population with hypertension in China: A national cross-sectional study
Authors: Zeng Xue-zhai , Jia Na , Meng Ling-bing , Shi Jing , Li Ying-ying , Hu Jia-bin , Hu Xing , Li Hui , Xu Hong-xuan , Li Jian-yi , Qi Xin , Wang Hua , Zhang Qiu-xia , Li Juan , Liu De-ping 
Published: January 2023

ObjectiveTo explore the prevalence and factors associated with frailty and pre-frailty in elderly Chinese patients with hypertension.BackgroundIn China, there have been few national studies into the prevalence and factors associated with frailty and pre-frailty in elderly patients with hypertension.MethodsThrough the 4th Sample Survey of Aged Population in Urban and Rural China (SSAPUR) in 2015, the situation of hypertension subjects aged 60 years or older in 31 provinces, autonomous regions, and municipalities in mainland China was obtained. And the frailty index was constructed based on 33 potential defects, elderly hypertensive patients are classified as robust, frailty, and pre-frailty.ResultsA total of 76,801 elderly patients with hypertension were enrolled in the study. The age-sex standardized prevalence of frailty and pre-frailty in hypertensive elderly in China was 16.1% (95%CI 15.8–16.3%), 58.1% (95%CI 57.7–58.4%). There were significant geographical differences in the prevalence of frailty and pre-frailty in elderly hypertensive patients. Multinomial logistic regression analysis showed that poor economic status, activities of daily living disability, and comorbid chronic diseases were related to frailty and pre-frailty.ConclusionFrailty and pre-frailty are very common in elderly Chinese patients with hypertension and have similar risk factors. Prevention strategies should be developed to stop or delay the onset of frailty by targeting established risk factors in the pre-frailty population of elderly hypertension. It is also crucial to optimize the management of frailty in elderly Chinese patients with hypertension.