bluuebunny/crossref_metadata_2025_split huggingface dataset:
Coenzyme Q10 and/or Vitamin E Supplementation for Polycystic Ovarian Syndrome
Authors: Irianto Christian Bobby , Prasetyadi Erick Giovanni 
Published: March 2023

Excessive androgens, insulin resistance, and changing estrogen levels in polycystic ovarian syndrome (PCOS) could affect the metabolic markers and lead to the increment of oxidative stress level. Coenzyme Q10 (CoQ10) is an organic molecule ubiquitously present in cell membranes and mitochondria. It is known to inhibit the peroxidation of cell membrane lipids and reduce the oxidation of circulating lipids, decreasing oxidative stress-induced cell damage. Vitamin E, an exogenous lipid-soluble molecule with antioxidant property, is a direct free radical scavenger that protects the cell membrane from lipid peroxidation and activates intracellular antioxidant enzymes. Some studies suggest that the cosupplementation of CoQ10 and vitamin E has strong synergistic outcomes in women with PCOS. The combination of those antioxidant agents is more likely to have better reproductive and metabolic outcomes.
Kadar androgen berlebih, resistensi insulin, dan perubahan kadar estrogen pada sindrom ovarium polikistik (SOPK) dapat memengaruhi parameter metabolik dan meningkatkan kadar stres oksidatif. Koenzim Q10 (CoQ10) merupakan molekul organik yang banyak ditemukan di dalam membran sel dan mitokondria. Molekul tersebut diketahui dapat menghambat proses peroksidasi lipid membran sel dan mengurangi proses oksidasi lipid dalam sirkulasi, sehingga berdampak mengurangi kerusakan sel yang disebabkan oleh reaksi stres oksidatif. Vitamin E yang merupakan molekul eksogen larut lemak berperan melindungi membran sel dari proses peroksidasi lipid dan membantu aktivasi enzim antioksidan intraseluler. Beberapa penelitian menunjukkan bahwa ko-suplementasi CoQ10 dan vitamin E memberikan dampak signifikan pada wanita dengan SOPK. Kombinasi dua antioksidan tersebut memberikan efek lebih baik dibandingkan pemberian terpisah.
Penggunaan Steroid Sistemik pada Henoch Schonlein Purpura
Authors: Masyalia Hasna Taqiyyah  
Published: March 2023

Steroid umum digunakan pada HSP mengingat efek antiinflamasinya. Namun, di lain pihak beberapa kasus HSP dapat sembuh sendiri hanya dengan terapi simtomatik ataupun suportif. Penelitian terkini menunjukkan bahwa steroid hanya bermanfaat pada beberapa kasus HSP. Penggunaan steroid harus dipertimbangkan berdasarkan indikasi dan tidak untuk setiap kasus HSP.
Steroids are commonly used in all cases of HSP because of its anti-inflammatory effect. However, some HSP cases are self-limiting and only necessitate symptomatic or supportive therapy. Recent research has shown that steroids are beneficial in only a few cases of HSP. Steroid should be used as indicated and considered in every case of HSP.
Peutz-Jeghers Syndrome
Authors: Mahendra Cipta 
Published: March 2023

Sindrom Peutz-Jeghers (Peutz-Jeghers Syndrome/PJS) merupakan penyakit herediter langka dengan ciri klinis pigmentasi mukokutaneus dan polip gastrointestinal. Hingga kini, satu-satunya upaya terapi adalah eliminasi polip melalui metode endoskopi dan/atau operasi laparatomi abdomen invasif. Penderita PJS memiliki risiko tinggi mendapat berbagai jenis kanker, sehingga diperlukan skrining rutin. Para penderita PJS perlu mendapat edukasi dan dukungan mental. Diperlukan riset lebih mendalam untuk tatalaksana terbaik sindrom PJS.
Peutz-Jeghers Syndrome (PJS) is rare hereditary disease with mucocutaneous pigmentations and gastrointestinal polyps as the most prominent clinical features. The only approved treatment is to eliminate the polyps by endoscopy and/or invasive abdominal laparotomy surgery. Patients with PJS have a high lifetime risk of various cancers and warrants regular surveillance for early signs of malignancies. PJS patients need to be well-informed and supported by the treating physicians to cope with their PJS status. More research in the management of PJS is needed
Pengaruh Pemberian Plasma Konvalesen terhadap Lama Rawat Inap Pasien COVID-19
Authors: Hermanadi Muhammad Ikrar , Theola Jason , Suryoadji Kemal Akbar , Nurfateen Ashadi Dhiya Athaullah 
Published: March 2023

Masih meningkatnya kasus positif dan kematian COVID-19 di Indonesia menuntut fasyankes agar bisa mempersingkat durasi hospitalisasi/ rawat inap untuk efisiensi sumber daya kesehatan dan peningkatan kualitas pelayanan. Terapi adjuvan pasien rawat inap antara lain terapi plasma konvalesen (TPK). Review ini bertujuan untuk mengetahui pengaruh pemberian TPK dan terapi standar dibandingkan terapi standar saja terhadap durasi rawat inap pasien COVID-19. Penelusuran artikel secara manual pada empat database, yaitu PubMed, Cochrane, ScienceDirect, dan Scopus. Kata kunci yang digunakan adalah convalescent plasma, COVID-19 therapy, COVID-19 serotherapy, length of stay. Metode seleksi berdasarkan kriteria eligibilitas mendapatkan 1 artikel yang kemudian ditelaah kritis dari segi kesahihan, kepentingan, dan kemamputerapan. Satu artikel tinjauan sistematis merupakan artikel yang sahih dan penting, tetapi kurang memiliki kemamputerapan karena demografi dan kondisi klinis yang tidak sesuai. Review ini menyimpulkan bahwa pemberian TPK tidak memengaruhi durasi rawat inap pasien COVID-19. Diperlukan studi lebih lanjut dengan demografi dan kondisi klinis yang sesuai untuk mendapat keyakinan tertinggi.
Indonesia is still in an ongoing trend of positive cases and deaths caused by COVID-19. This condition urges health care facilities to reduce length of stay for more efficient health resources management and higher quality of care. Adjuvant therapy to hospitalized patients includes convalesent plasma therapy (CPT). This review aims to determine the effect of CPT on length of stay of COVID-19 patients in comparison to standard therapy. Literature search is through hand searching and through four databases: PubMed, Cochrane, ScienceDirect, and Scopus. Keywords used are: convalescent plasma, COVID-19 therapy, COVID-19 serotherapy, length of stay. Selection through eligibility criteria resulted in one systematic review article, then critically appraised by its’ validity, importance, and applicability.The article selected is valid and important, yet lack of applicability due to discrepancy in demographics and clinical conditions. The review concluded that CPT does not affect the length of stay of COVID-19 patients.More research with similiar demographics and clinical conditions are needed to achieve highest level of certainty.
Tatalaksana Melanoma Maligna Kutaneus
Authors: Chandra Rudi 
Published: March 2023

Melanoma merupakan suatu tumor maligna dari melanosit, dengan lokasi paling sering adalah kulit (95% kasus). Tatalaksana melanoma tergantung stadium saat diagnosis; dengan pembedahan masih merupakan pilihan utama. Pengobatan melanoma primer adalah bedah eksisi definitif dengan batas eksisi berdasarkan ketebalan tumor. Pada keterlibatan nodus limfatikus regional, dapat dilakukan diseksi elektif komplit. Pada rekurensi lokal dilakukan bedah reseksi komplit dengan penutupan luka primer atau eksisi lokal luas disertai skin grafting ataupun penutupan flap. Metastasis melanoma dibedakan menjadi metastasis kulit atau jauh. Tatalaksana metastasis melanoma dapat berupa terapi sistemik (targeted therapy, terapi imun, dan kemoterapi) dan/atau radiasi. Terapi adjuvan diberikan hanya untuk pasien tanpa bukti metastasis tetapi berisiko tinggi penyebaran tumor lebih lanjut.
Melanoma is a malignant tumor of melanocytes, the most frequent location is in the skin (95% cases). Management of melanoma depends on the stage at diagnosis. Surgery is still the main choice of therapy. Treatment of primary melanoma is definitive excision surgery with excision limit based on the thickness of the tumor. In regional lymph node involvement, complete elective dissection can be performed. In local recurrence, complete resection is performed with primary wound closure or extensive local excision with skin grafting or flap closure. Treatment of melanoma metastasis can be divided into skin metastases or distant. Management of melanoma metastases can be systemic therapy (targeted therapy, immune therapy, and chemotherapy) and radiation. Adjuvant therapy is only given to patients without evidence of metastasis but is at high risk for further spread of the tumor.
Katarak Kongenital: Skrining dan Diagnosis
Authors: Priskila Taba Junetta Airene 
Published: March 2023

Katarak kongenital merupakan kekeruhan lensa yang terjadi sejak lahir dan berpotensi menyebabkan gangguan penglihatan hingga kebutaan. Pemeriksaan red reflex pada bayi baru lahir sangat penting untuk deteksi dini kelainan tersebut. Pemeriksaan mata lanjutan untuk diagnosis antara lain slit-lamp, ultrasound, funduskopi, serta tajam penglihatan. Katarak kongenital yang mengganggu fungsi penglihatan dapat ditatalaksana dengan teknik operasi.
Congenital cataract is lens opacity that occurs since birth and can potentially cause visual impairment, even blindness. Red reflex examination in newborn is very important for early screening. Further diagnostic eye examination includes slit lamp, ultrasound, funduscopy, and visual acuity. Congenital cataract that impairs vision can be managed surgically.
Efektivitas N-Acetylsistein pada Pasien COVID-19
Authors: Sujana Karlina Sari , Maulida Munfika 
Published: March 2023

COVID-19 disebabkan oleh virus SARS-Cov-2 dan menyebabkan morbiditas dan mortalitas yang tinggi. COVID-19 dapat menyebabkan pneumonia, sindrom gangguan pernapasan akut, perubahan kardiovaskular, dan kegagalan multi organ, yang dianggap berasal dari mekanisme badai sitokin, respons peradangan sistemik, dan serangan sistem kekebalan. N-acetylcysteine (NAC) telah digunakan dalam klinis untuk mengobati pasien sepsis dengan kondisi kritis. NAC memiliki karakteristik antioksidan, antiinflamasi, dan modulasi kekebalan yang bermanfaat menurunkan risiko perburukan COVID-19.
COVID-19 is caused by SARS-Cov-2 virus, and is known to cause high morbidity and mortality. COVID-19 causes pneumonia, acute respiratory distress syndrome, cardiovascular changes, and multi-organ failure, correlated to cytokine storm mechanisms, systemic inflammatory responses, and immune system attacks. N-acetylcysteine (NAC) has been used in clinical practice to treat sepsis patients with critical conditions. NAC has antioxidant, anti-inflammatory, and immune modulation characteristics beneficial to reduce the risk of COVID-19 worsening.
Tinjauan Klinis CADASIL (Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy)
Authors: Dwi Anandika Danar 
Published: March 2023

CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy) adalah penyakit herediter langka dengan prevalensi 4,14 per 100.000. Penyakit ini disebabkan mutasi gen Notch 3 pada kromosom 19. Manifestasi klinisnya bervariasi dengan onset gejala awal migrain dengan aura. Pada tahap lanjut akan dijumpai lesi infark multipel di area subkortikal. Pasien juga dapat mengalami gangguan psikiatri dan neurobehaviour. Tidak ada terapi kausal, dapat diberikan terapi simptomatik.
CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy) is a rare hereditary disease with a prevalence of 4.14 per 100,000. The disease is caused by a mutation of the Notch 3 gene on chromosome 19. The clinical manifestations vary with the onset of initial symptoms is migraine with aura. In advanced stages, there will be multiple infarct lesions in the subcortical area. Patients may also experience psychiatric and neurobehavioral disorders. There is no causal therapy, only symptomatic therapy.
Pengaruh Coronavirus Disease 2019 (COVID-19) terhadap Insidens dan Tatalaksana Penyakit Serebrovaskular
Authors: Hamidjoyo Billy Priyanto , Wreksoatmodjo Budi Riyanto 
Published: March 2023

COVID-19 dikenal dengan manifestasi klinis terkait saluran pernapasan seperti batuk, sesak, dan demam. Namun, saat ini telah banyak diteliti bahwa COVID-19 dapat menimbulkan gejala di luar sistem pernapasan, salah satunya ke sistem saraf. Pelaporan kejadian stroke pada pasien COVID-19 masih bervariasi, namun pada pasien COVID-19, khususnya yang bergejala berat terdapat kondisi hiperkoagulasi yang dapat menyebabkan komplikasi trombotik seperti trombosis vena dalam dan diduga berkaitan dengan risiko stroke pada pasien COVID-19.
COVID-19 is known for its clinical manifestations related to the respiratory tract such as cough, shortness of breath, and fever. However, currently it has been widely studied that COVID-19 can cause symptoms outside the respiratory system, one of which is the nervous system. Reports of stroke events in COVID-19 patients still vary, but in COVID-19 patients, especially those with severe symptoms, there is a hypercoagulable condition that can cause thrombotic complications such as deep vein thrombosis and is thought to be associated with the risk of stroke in COVID-19 patients.
Aspek Neurobiologi dan Neuroimaging Bunuh Diri
Authors: Safitri Dian Oktaria , AAAA. Kusumawardhani  
Published: March 2023

Sejumlah 50% pelaku bunuh diri pernah melakukan percobaan bunuh diri sebelumnya. Sulitnya prediktor klinis dan tidak terdapatnya biomarker spesifik, menyulitkan prediksi perilaku bunuh diri. Perkembangan neurobiologi dan neuroimaging dapat memprediksi terjadinya upaya bunuh diri.
Fifty percent individuals who committed suicide have previously conducted suicide attempts. Rare clinical predictors and the absence of specific biomarkers, lead to difficulties in predicting suicidal behavior. Neurobiology and neuroimaging may predict the occurrence of suicide.
Diagnosis dan Tatalaksana Kegawatdaruratan Hiperkalemia
Authors: Teo Gloria 
Published: March 2023

Hiperkalemia ialah kadar kalium plasma/ serum yang melebihi batas atas rentang normal, yaitu ≥5,5 mEq/L; dapat bervariasi tergantung cut off laboratorium dan sampel pemeriksaan. Hiperkalemia sering dijumpai di instalasi gawat darurat (IGD). Hiperkalemia berat dapat meningkatkan risiko mortalitas hingga 30%, karena menyebabkan aritmia yang mengancam nyawa, seperti fibrilasi ventrikel dan asistol. Hiperkalemia dapat disebabkan oleh perpindahan K+ intraseluler menuju ekstraselular, ekskresi inadekuat, dan intake K+ berlebih pada pasien gangguan ginjal. Tatalaksana hiperkalemia meliputi upaya menstabilkan miokard dan mencegah/ memperbaiki disritmia, redistribusi/pemindahan K+ menuju intraseluler, serta meningkatkan ekskresi K+.
Hyperkalemia is defined as a serum or plasma potassium level above the upper limits of normal range, usually ≥5,5 mEq/L; may vary depending on each laboratory cut off and sample. Hyperkalemia is the most common electrolyte disorder in emergency department. Severe hyperkalemia may increase the mortality up to 30% due to fatal arrhythmia, such as ventricular fibrillation and asystole. Hyperkalemia might be caused by potassium shift to extracellular compartment, inadequate excretion, and increased potassium intake in patients with decreased renal function. Management of hyperkalemia include myocardial stabilization and preventing/ improving dysrhythmia, redistribution/ shifting potassium back to intracellular compartment, and increasing potassium excretion.
Microscopic evaluation of fissure patterns of posterior permanent teeth: An in vitro study
Authors: Büyükgöze Dindar Mediha , Tekbaş Atay Meltem 
Published: March 2023

Aim: Pits and fissures are considered the areas in the posterior teeth that are most susceptible to decay. The aim of this in vitro study was to evaluate the prevalence of fissure types in relation to tooth type and localization.
Methodology: A total of 100 extracted sound maxillary and mandibular molars and premolars were included in this study (25 teeth/group). The extracted teeth without any caries, cracks, fractures, anomalies, or restorations were classified according to tooth type and localization after disinfection. The teeth were sectioned in the buccolingual direction from the deepest part of the central fossa on the occlusal surface, and the fissure patterns were observed using a stereo microscope. The frequency distribution and percentages of the categorical data were obtained. Chi-square and exact tests were performed to compare the localization of the teeth and the prevalence of fissure types (p < 0.05).
Results: The V-type fissure pattern (59%) was statistically significantly more common in both the premolar and molar teeth, followed by the I-type (18%) and U-type (14%) patterns (p = 0.000). The rarest fissure pattern was the IK type. No relationships were found between fissure pattern, the tooth subgroups, and localization (p = 0.390).
Conclusion: Determining the types of fissure morphology is important for the prevention of caries on the occlusal surfaces of molars and premolars.

How to cite this article:
Büyükgöze Dindar M, Tekbaş Atay M. Microscopic evaluation of fissure patterns of posterior permanent teeth: An in vitro study. Int Dent Res 2022;12(3):107-11. https://doi.org/10.5577/intdentres.2022.vol12.no3.1

Linguistic Revision: The English in this manuscript has been checked by at least two professional editors, both native speakers of English.
Dental implant failure in immunosuppressed renal transplant patient: A case report
Authors: Güler Berceste , Terzioğlu Büşra , Çukurluöz Bayındır Banu , Dal Gülen 
Published: March 2023

Background: In the literature, the dental implant survival rate has been reported one hundred percent in immunosuppressed patients after a solid organ transplant (SOT). There is no previously published dental implant failure that has been reported on immunosuppressed renal transplant, which is the most common SOT therapy.
Case Report: The case presented is that of a 66-years old male edentulous patient suffering from lack of functional prosthesis and who received a renal transplant two years ago. No complications such as infection, radiolucency, or pus were detected after two dental implants were placed in the mandible and after three months recovery period. The right mandibular dental implant failure occurred due to compression of the dental implant and healing head during the delivery of the patient’s removable prosthesis. Following implant socket healing after two months, the 4.8 mm diameter implant was placed immediately after. Osseointegration was completed uneventfully, and the patient was successfully rehabilitated with a two implant-retained mandibular overdenture prosthesis. The implant restoration was performing well with stable Peri-implant bone levels have shown minimal marginal bone loss at a 2-year follow-up.
Conclusion: Treatment of combined immunosuppressive medication used in renal transplant patients after dental implant rehabilitation, as well as accompanying chronic diseases, should be performed considering the possibility of failure in dental implant applications. In this case report, the causes of implant failure were reported patients who received dental implant treatment after renal transplantation from a cadaver.

How to cite this article:
Güler B, Özaltun B, Çukurluöz Bayındır B, Dal G. Dental implant failure in immunosuppressed renal transplant patient: A case report. Int Dent Res 2022;12(3):171-5. https://doi.org/10.5577/intdentres.2022.vol12.no3.10

Linguistic Revision: The English in this manuscript has been checked by at least two professional editors, both native speakers of English.
The frequency and degree of expression of Carabelli’s trait on the permanent maxillary molars in a sample of Turkish individuals
Authors: Yılancı Hümeyra Özge , Özkan Gökhan , Akkaya Nursel , Boyacıoğlu Hatice 
Published: March 2023

Aim: Carabelli’s trait, a morphological feature on the mesiopalatal surface of the maxillary molars, has importance in anthropology, forensic sciences, and clinical dentistry. The aim of this study was to find the frequency and degree of expression of Carabelli’s trait and to assess the asymmetry of the trait, on three permanent maxillary molars in a sample of Turkish individuals.
Methodology: Carabelli’s trait was evaluated using Dahlberg’s eight-grade scale on 462 subjects. Data were analyzed using a chi-square test.
Results: The frequencies in the total, positive and negative expressions of the trait were, respectively, 64.5%, 37.7% and 26.8% on the first molars, 27.1%, 19.6% and 7.6% on the second molars and 10.3%, 8.7% and 1.6% on the third molars. The occurrence of the trait on the first and second molars was more prevalent in males than in females. The trait was most frequently bilateral and symmetrical without significant sex differences, with varying degrees of asymmetry that increased from the first to the third molars. The frequencies of presence-absence asymmetry and any degree of asymmetry on the first molars were 5.3% and 15.7%, respectively.
Conclusion: This study revealed a comparatively high frequency of Carabelli’s trait with a relatively low asymmetry in a contemporary Turkish sample. This data has the potential to be used for anthropological, forensic, and clinical purposes.

How to cite this article:
Yılancı HÖ, Özkan G, Akkaya N, Boyacıoğlu H. The frequency and degree of expression of Carabelli’s trait on the permanent maxillary molars in a sample of Turkish individuals. Int Dent Res 2022;12(3):112-9. https://doi.org/10.5577/intdentres.2022.vol12.no3.2

Linguistic Revision: The English in this manuscript has been checked by at least two professional editors, both native speakers of English.
Rancang Bangun Aplikasi Pemesanan Obat Pada Apotik Mitha Farma Berbasis Web Dan Android
Authors: Zebua Jonatan , Sembiring Nita Sari Br 
Published: March 2023

Apotek Mitha Farma salah satu usaha yang menjual obat-obatan. Permasalahan Apotek Mitha Farma selama ini adalah pelanggan harus datang langsung ke Apotek Mitha Farma untuk membeli dan memesan obat, sehingga proses penjualan di Apotek Mitha Farma tidak dapat berjalan efektif. Jika pesanan yang diterima Apotek Mitha Farma lumayan banyak, pekerja harus mengecek stok obat di gudang untuk memenuhi orderan klien sebab proses penjualan obat membutuhkan waktu yang cukup lama. Diperlukan sesuatu sistem yang bisa membantu Apotek Mitha Farma dan kliennya dalam penjualan obat-obatan, serta memudahkan klien untuk memesan obat dan memperjelas jenis dan harga obat yang akan dipesan, serta membantu Apotek Mitha Farma dalam memahami persediaan obat saat ini di gudang. Sistem yang penulis sarankan menggabungkan framework. Pelanggan dapat memesan obat tanpa harus mengunjungi Apotek Mitha Farma secara fisik dengan melakukan pemesanan melalui aplikasi pemesanan obat rancangan peneliti. dengan perangkat Android dan membantu pelanggan membayar pesanan menggunakan sistem COD (bayar di loket) atau transfer. Selain itu, hal ini akan memudahkan Apotek Mitha Farma untuk melihat sisa obat yang masih ada dan produk yang dipesan klien.
osialiasi dan Pemanfaatan Transformasi Digital Sistem Manajemen Kebun Sawit (SIMAKS) Menggunakan Smartphone Pada Kelompok Tani Rawa Subur Desa Gabung Makmur
Authors: Duha Yermias 
Published: March 2023

Dalam sistem pengontrolan perhitungan norma pengupahan dan pengontrolan rotasi pemeliharaan pada kelompok Tani Rawa Subur Desa Gabung Makmur Kecamatan Kernci Kanan yang tergabung dalam Koperasi Kebun Sawit Harapan Makmur memiliki beberapa permasalahan yang dihadapi yaitu : 1) Belum menggunakan sistem basis dan norma biaya dalam perhitungan upah. 2) Belum mampu mengontrol rencana anggaran biaya dan rotasi pemeliharaan kebun. 3) Belum tersedianya IPTEK pada Kelompok Tani Rawa Subur. 4) Laporan masih dikerjakan secara manual. Berdasarkan permasalahan yang dihadapi mitra maka solusi dari permasalahana tersebut yaitu: 1) Sosialiasi dan pemanfaatan transformasi digital Sistem Manajemen Kebun Sawit (SIMAKS) menggunakan smartphone. 2) Pelatihan kerani tentang sistem pengupahan dengan sistem menggunakan basis dan norma biaya. 3) Implementasi dan sosialisasi menggunakan aplikasi Sistem Manajemen Kebun Sawit (SIMAKS) 4) Sosialasi membuat rencana anggaran belanja (RAB), rotasi pemeliharaan dan menentukan dosis pemupukan.