bluuebunny/crossref_metadata_2025_split huggingface dataset:
Central exclusive diffractive production of two pions from continuum and resonance decay in the Regge-eikonal model
Authors: Ryutin R. A. 
Published: February 2023

AbstractCalculations of the central exclusive diffractive production (CEDP) of two pions via continuum and resonance mechanisms are presented in the Regge-eikonal approach. Data from STAR, ISR, CDF and CMS are analysed and compared with theoretical descriptions. The preliminary extraction of $$f_0(500)$$

f
0

(
500
)

, $$f_0(980)$$

f
0

(
980
)

and $$f_2(1270)$$

f
2

(
1270
)

couplings to pomerons and the $$\rho $$
ρ
meson contribution from the photoproduction mechanism to the CEDP cross-section are considered. We show possible nuances and problems of calculations and prospects of investigations at current and future hadron colliders.
Elucidation of
ALG10B
as a Novel Long-QT Syndrome–Susceptibility Gene
Authors: Zhou Wei , Ye Dan , Tester David J. , Bains Sahej , Giudicessi John R. , Haglund-Turnquist Carla M. , Orland Kate M. , January Craig T. , Eckhardt Lee L. , Maginot Kathleen R. , Ackerman Michael J. 
Published: February 2023

Background:

Long-QT syndrome (LQTS) is characterized by QT prolongation and increased risk for syncope, seizures, and sudden cardiac death. The majority of LQTS stems from pathogenic mutations in
KCNQ1
,
KCNH2
, or
SCN5A
. However, ≈10% of patients with LQTS remain genetically elusive. We utilized genome sequencing to identify a novel LQTS genetic substrate in a multigenerational genotype-negative LQTS pedigree.

Methods:
Genome sequencing was performed on 5 affected family members. Only rare nonsynonymous variants present in all affected family members were considered. The candidate variant was characterized functionally in patient-derived induced pluripotent stem cell and gene-edited, variant corrected, isogenic control induced pluripotent stem cell–derived cardiomyocytes.

Results:

A missense variant (p.G6S) was identified in
ALG10B
-encoded α-1,2-glucosyltransferase B protein. ALG10B (alpha-1,2-glucosyltransferase B protein) is a known interacting protein of
KCNH2
-encoded K
v
11.1 (HERG [human Ether-à-go-go–related gene]). Compared with isogenic control, ALG10B-p.G6S induced pluripotent stem cell–derived cardiomyocytes showed (1) decreased protein expression of ALG10B (p.G6S, 0.7±0.18, n=8 versus control, 1.25±0.16, n=9;
P
<0.05), (2) significant retention of HERG in the endoplasmic reticulum (
P
<0.0005), and (3) a significantly prolonged action potential duration confirmed by both patch clamp (p.G6S, 531.1±38.3 ms, n=15 versus control, 324.1±21.8 ms, n=13;
P
<0.001) and multielectrode assay (
P
<0.0001). Lumacaftor—a compound known to rescue HERG trafficking—shortened the pathologically prolonged action potential duration of ALG10B-p.G6S induced pluripotent stem cell–derived cardiomyocytes by 10.6% (n=31 electrodes;
P
<0.001).

Conclusions:

Here, we demonstrate that ALG10B-p.G6S downregulates ALG10B, resulting in defective HERG trafficking and action potential duration prolongation. Therefore,
ALG10B
is a novel LQTS-susceptibility gene underlying the LQTS phenotype observed in a multigenerational pedigree. ALG10B mutation analysis may be warranted, especially in genotype-negative patients with an LQT2-like phenotype.
Paisaje Sonoro Social: Socially Engaged Soundscapes in Mexico
Authors: Duarte-García Mario Alberto , Wilde Emma 
Published: February 2023

Abstract
Latin America has a tradition of socially engaged artists. In Mexico, since the muralist movement of the 1920s, artists have shown a preoccupation for denouncing social issues in their works. In this article, we propose the concept of Paisaje sonoro social [socially engaged soundscapes], an approach to the composition of sound art that aims to raise awareness about specific social issues experienced in Mexican society. Through the combination of oral testimony, soundscapes (both real and imagined), and instrumental and electroacoustic music, Paisaje sonoro social aims to provide a direct communication to the listener in order to draw attention to social issues such as child exploitation, migration, poor working conditions for factory workers, poverty, and children working in the touristic industry.
Through the analysis of a series of six works we argue that, although Paisaje sonoro social shares features of other genres, such as soundscape composition, acousmatic storytelling, and documental sonoro [radio feature] it has fundamental differences
Achieving Transparency: A Metadata Perspective
Authors: Gillman Daniel 
Published: February 2023

ABSTRACTTransparency is vital to realizing the promise of evidenced-based policymaking, where “evidence-based” means including information as to what data mean and why they should be trusted. Transparency, in turn, requires that enough of this information is provided. Loosely speaking then, transparency is achieved when sufficient documentation is provided. Sufficiency is situation specific, both for the provider and consumer of the documentation. These ideas are presented in two recent US commissioned reports: The Promise of Evidence-Based Policymaking and Transparency in Statistical Information for the National Center for Science and Engineering Statistics and All Federal Statistical Agencies.Metadata are a more formalized kind of documentation, and in this paper, we provide and demonstrate necessary, sufficient, and general conditions for achieving transparency from the metadata perspective: conforming to a specification, providing quality metadata, and creating a usable interface to the metadata. These conditions are important for any metadata system, but here the specification is tied to our framework for metadata quality based on the situation-specific needs for transparency. These ideas are described, and their interrelationships are explored.
The Influence of Synoptic-Scale Wind Patterns on Column-Integrated Nitrogen Dioxide, Ground-Level Ozone, and the Development of Sea-Breeze Circulations in the New York City Metropolitan Area
Authors: Nauth Dilchand , Loughner Christopher P. , Tzortziou Maria 
Published: February 2023

Abstract
The continually changing atmospheric conditions over densely populated coastal urban regions make it challenging to produce models that accurately capture the complex interactions of anthropogenic and environmental emissions, chemical reactions, and unique meteorological processes, such as sea- and land-breeze circulations. The purpose of this study is to determine and identify the influence of synoptic-scale wind patterns on the development of local-scale sea-breeze circulations and air quality over the New York City (NYC), New York, metropolitan area. This study utilizes column-integrated nitrogen dioxide observations made during the Long Island Sound Tropospheric Ozone Study (LISTOS) field campaign, ground-level ozone observations, the HRRR numerical weather prediction model, and trajectory model simulations using the NOAA HYSPLIT model. A cluster analysis within the HYSPLIT modeling system was performed to determine that there were six unique synoptic-scale transport pathways for NYC. Stagnant conditions or weak transport out of the northwest resulted in the worst air quality for NYC. Weak synoptic-scale forcings associated with these conditions allowed for local-scale sea-breeze circulations to develop, resulting in air pollution being able to recirculate and mix with freshly emitted pollutants.

Significance Statement
The purpose of this work is to understand how synoptic-scale wind patterns influence air quality and sea-breeze circulations in the New York City, New York, metropolitan area. This work shows that clean air can be imported into the region from rural New England and over the Atlantic Ocean, whereas polluted air can be transported into the region from the northwest and southwest. This work also shows the importance of the strength in synoptic-scale forcings in the development of sea-breeze circulations. Weak synoptic-scale winds allow for strong sea-breeze circulations to develop over all coastlines in the New York City region, resulting in air pollutants recirculating and mixing with freshly emitted air pollution and contributing to poor air quality.
Top Ten Research Priorities for Psoriasis, Atopic Dermatitis and Hidradenitis Suppurativa: The SkIN Canada Priority Setting Initiative
Authors: Drucker Aaron M. , Kleiner Omer , Manion Rachael , Philip Anie , Dutz Jan , Barnard Kathleen , Fradette Julie , Germain Lucie , Gniadecki Robert , Litvinov Ivan , Logsetty Sarvesh , Manolson Morris , Mydlarski P. Régine , Piguet Vincent , Ward Debbie , Zhou Youwen , Chan An-Wen ,   the Skin Investigation Network of Canada Priority Setting Collaborative, Abbas Mariam , Alhusayen Raed , Cenedese Lisa , Chen Tiffany , Cheng Yee Sing , Cole Trish , Iuliis Jacob De , Desaulniers Katherine , Duffy Catherine , Ferris Tracy , Hanna Sameh , Humeny Rhiannon , Joseph Marissa , Khan Ushra , Lynde Charles , Morrison Steven , Ogunyemi Boluwaji , Prajapati Vimal , Ramien Michele , Reynolds Lauren , Rosen Cheryl , Seguin Kimberly , Sibbald Cathryn , Swan Jennifer , Timgren Jodi , Turchin Irina , Verner Vicky , Walsh Sandra , Weston Veronica 
Published: February 2023

Background The Skin Investigation Network of Canada (SkIN Canada) is a new national skin research network. To shape the research landscape and ensure its value to patient care, research priorities that are important to patients, caregivers, and health care providers must be identified. Objectives To identify the Top Ten research priorities for 9 key skin conditions. Methods We first surveyed health care providers and researchers to select the top skin conditions for future research within the categories of inflammatory skin disease, skin cancers (other than melanoma), and wound healing. For those selected skin conditions, we conducted scoping reviews to identify previous priority setting exercises. We combined the results of those scoping reviews with a survey of patients, health care providers, and researchers to generate lists of knowledge gaps for each condition. We then surveyed patients and health care providers to create preliminary rankings to prioritize those knowledge gaps. Finally, we conducted workshops of patients and health care providers to create the final Top Ten lists of research priorities for each condition. Results Overall, 538 patients, health care providers, and researchers participated in at least one survey or workshop. Psoriasis, atopic dermatitis and hidradenitis suppurativa (inflammatory skin disease); chronic wounds, burns and scars (wound healing); and basal cell, squamous cell and Merkel cell carcinoma (skin cancer) were selected as priority skin conditions. Top Ten lists of knowledge gaps for inflammatory skin conditions encompassed a range of issues relevant to patient care, including questions on pathogenesis, prevention, non-pharmacologic and pharmacologic management. Conclusions Research priorities derived from patients and health care providers should be used to guide multidisciplinary research networks, funders, and policymakers in Canada and internationally.
Measuring operating theatre nurses’ perceptions of safety culture using the SCORE questionnaire
Authors: Deguara Justin , Trapani Josef , Ebejer Stephen 
Published: February 2023

Background: Tackling operating theatre waiting lists may focus healthcare organisations’ attention on increased productivity while downplaying safety concerns. Aim: To explore safety culture in a perioperative department from operating theatre practitioners’ perspective. Method: Cross-sectional pen-and-paper survey among nurses in an operating theatre department in Malta using the Safety, Communication, Operational Reliability and Engagement questionnaire. Findings: The response rate was 71.2% (n = 146). Engagement domains and Organisational Safety Culture domains were perceived to be at an average level, apart from Unit Leadership which was perceived to be low. Burnout domains were perceived to be high or very high. Correlation analysis showed that leaders’ recognition of staff feedback and input is associated with improved safety culture perceptions. Conclusion: An organisational win-win situation is achievable, whereby safety culture perceptions are improved, not necessarily by decreasing job demands such as tackling waiting lists, but by recognising operating theatre staff’s input and involving them in work-related decisions.
The effect of geographic origin and destination on congenital heart disease outcomes: a retrospective cohort study
Authors: Millen Spencer M. , Olsen Cara H. , Flanagan Ryan P. , Scott John S. , Dobson Craig P. 
Published: February 2023

Abstract
Background
Congenital heart disease (CHD) is a common and significant birth defect, frequently requiring surgical intervention. For beneficiaries of the Department of Defense, a new diagnosis of CHD may occur while living at rural duty stations. Choice of tertiary care center becomes a function of geography, referring provider recommendations, and patient preference.

Methods
Using billing data from the Military Health System over a 5-year period, outcomes for beneficiaries age < 10 years undergoing CHD surgery were compared by patient origin (rural versus urban residence) and the distance to treatment (patient’s home and the treating tertiary care center). These beneficiaries include children of active duty, activated reserves, and federally activated National Guard service members. Analysis of the outcomes were adjusted for procedure complexity risk. Treatment centers were further stratified by annual case volume and whether they publicly reported results in the society of thoracic surgery (STS) outcomes database.

Results
While increasing distance was associated with the cost of admission, there was no associated risk of inpatient mortality, one year mortality, or increased length of stay. Likewise, rural origination was not significantly associated with target outcomes. Patients traveled farther for STS-reporting centers (STS-pr), particularly high-volume centers. Such high-volume centers (> 50 high complexity cases annually) demonstrated decreased one year mortality, but increased cost and length of stay.

Conclusions
Together, these findings contribute to the national conversation of rural community medicine versus regionalized subspecialty care; separation of patients between rural areas and more urban locations for initial CHD surgical care does not increase their mortality risk. In fact, traveling to high volume centers may have an associated mortality benefit.
Comparison of paediatric infectious disease deaths in public sector health facilities using different data sources in the Western Cape, South Africa (2007–2021)
Authors: Kehoe K. , Morden E. , Jacobs T. , Zinyakatira N. , Smith M. , Heekes A. , Murray J. , le Roux D. M. , Wessels T. , Richards M. , Eley B. , Jones H. E. , Redaniel M. T. , Davies M. A. 
Published: February 2023

Abstract
Background
Routinely collected population-wide health data are often used to understand mortality trends including child mortality, as these data are often available more readily or quickly and for lower geographic levels than population-wide mortality data. However, understanding the completeness and accuracy of routine health data sources is essential for their appropriate interpretation and use. This study aims to assess the accuracy of diagnostic coding for public sector in-facility childhood (age < 5 years) infectious disease deaths (lower respiratory tract infections [LRTI], diarrhoea, meningitis, and tuberculous meningitis [TBM]) in routine hospital information systems (RHIS) through comparison with causes of death identified in a child death audit system (Child Healthcare Problem Identification Programme [Child PIP]) and the vital registration system (Death Notification [DN] Surveillance) in the Western Cape, South Africa and to calculate admission mortality rates (number of deaths in admitted patients per 1000 live births) using the best available data from all sources.

Methods
The three data sources: RHIS, Child PIP, and DN Surveillance are integrated and linked by the Western Cape Provincial Health Data Centre using a unique patient identifier. We calculated the deduplicated total number of infectious disease deaths and estimated admission mortality rates using all three data sources. We determined the completeness of Child PIP and DN Surveillance in identifying deaths recorded in RHIS and the level of agreement for causes of death between data sources.

Results
Completeness of recorded in-facility infectious disease deaths in Child PIP (23/05/2007–08/02/2021) and DN Surveillance (2010–2013) was 70% and 69% respectively. The greatest agreement in infectious causes of death were for diarrhoea and LRTI: 92% and 84% respectively between RHIS and Child PIP, and 98% and 83% respectively between RHIS and DN Surveillance. In-facility infectious disease admission mortality rates decreased significantly for the province: 1.60 (95% CI: 1.37–1.85) to 0.73 (95% CI: 0.56–0.93) deaths per 1000 live births from 2007 to 2020.

Conclusion
RHIS had accurate causes of death amongst children dying from infectious diseases, particularly for diarrhoea and LRTI, with declining in-facility admission mortality rates over time. We recommend integrating data sources to ensure the most accurate assessment of child deaths.
INTEGRATE II: randomised phase III controlled trials of regorafenib containing regimens versus standard of care in refractory Advanced Gastro-Oesophageal Cancer (AGOC): a study by the Australasian Gastro-Intestinal Trials Group (AGITG)
Authors: Lam Lyn Ley , Pavlakis Nick , Shitara Kohei , Sjoquist Katrin M. , Martin Andrew J. , Yip Sonia , Kang Yoon-Koo , Bang Yung-Jue , Chen Li-Tzong , Moehler Markus , Bekaii-Saab Tanios , Alcindor Thierry , O’Callaghan Christopher J. , Tebbutt Niall C. , Hague Wendy , Chan Howard , Rha Sun Young , Lee Keun-Wook , Gebski Val , Jaworski Anthony , Zalcberg John , Price Timothy , Simes John , Goldstein David 
Published: February 2023

Abstract
Background
Advanced gastro-oesophageal cancer (AGOC) carries a poor prognosis. No standard of care treatment options are available after first and second-line therapies. Regorafenib is an oral multi-targeted tyrosine kinase inhibitor targeting angiogenic, stromal, and oncogenic receptor tyrosine kinases. Regorafenib 160 mg daily prolonged progression free survival compared to placebo (INTEGRATE, phase 2). Regorafenib 80 mg daily in combination with nivolumab 3 mg/kg showed promising objective response rates (REGONIVO).

Methods/design
INTEGRATE II (INTEGRATE IIa and IIb) platform comprises two international phase III randomised controlled trials (RCT) with 2:1 randomisation in favor of experimental intervention. INTEGRATE IIa (double-blind) compares regorafenib 160 mg daily on days 1 to 21 of each 28-day cycle to placebo. INTEGRATE IIb (open label) compares REGONIVO, regorafenib 90 mg days 1 to 21 in combination with intravenous nivolumab 240 mg days 1 and 15 each 28-day cycle with investigator’s choice of chemotherapy (control). Treatment continues until disease progression or intolerable adverse events as per protocol. Eligible participants include adults with AGOC who have failed two or more lines of treatment. Stratification is by location of tumour (INTEGRATE IIa only), geographic region, prior VEGF inhibitor and prior immunotherapy use (INTEGRATE IIb only). Primary endpoint is overall survival. Secondary endpoints are progression free survival, objective response rate, quality of life, and safety. Tertiary/correlative objectives include biomarker and pharmacokinetic evaluation.

Discussion
INTEGRATE II provides a platform to evaluate the clinical utility of regorafenib alone, as well as regorafenib in combination with nivolumab in treatment of participants with refractory AGOC.

Trial registration
INTEGRATE IIa prospectively registered 1 April 2016 Australia New Zealand Clinical Trial Registry: ACTRN12616000420448 (ClinicalTrials.gov NCT02773524). INTEGRATE IIb prospectively registered 10 May 2021 ClinicalTrials.gov: NCT04879368.
International border malaria transmission in the Ethiopian district of Lare, Gambella region: implications for malaria spread into South Sudan
Authors: Haileselassie Werissaw , Ejigu Abebe , Alemu Tesfahun , Workneh Sale , Habtemichael Mizan , David Randy E. , Lelisa Kidane , Deressa Wakgari , Yan Guiyun , Parker Daniel M. , Taye Behailu 
Published: February 2023

Abstract
Background
Despite notable progress in the control and prevention of malaria in the Horn of Africa, the disease continues to cause significant morbidity and mortality in various regions of Ethiopia, and elsewhere in the region. The transmission of malaria is affected by genetic, sociocultural, and ecological factors. Lare is an Ethiopian district adjacent to the Ethio-South Sudan border, in Gambella region. The region currently has the highest prevalence of malaria in Ethiopia. This study assesses the burden and spatiotemporal patterns of disease transmission, including the effect of climatic factors on the occurrence of malaria, across an international border crossing. This understanding can assist in crafting informed programmatic and policy decisions for interventions.

Methods
This study was conducted in Lare district, Southwest Ethiopia, a temperate zone. A retrospective descriptive analysis was conducted using clinical service data collected between 2011 and 2021 from the 9 health facilities of the district. Both clinically diagnosed patients and those identified using microscopy and rapid diagnostic testing (RDT) were included in the study. Additionally, climate data was incorporated into analyses. Examples of analyses include malaria burden, positivity rate, incidence, species frequency, and an ANOVA to assess inter-annual case number and meteorological factor variation.

Results
Between 2011 and 2021, a total of 96,616 suspected malaria cases were tested by microscopy or RDT, and 39,428 (40.8%) of these cases were reported as positive. There were 1276 patients admitted with 22 deaths recorded. There were further more significant fluctuations in positivity rates across years, the highest being 74.5% in 2021. Incidence varied from 18.0% in 2011 to 151.6% in 2016. The malaria parasite species most detected was Plasmodium falciparum, followed by a smaller proportion of Plasmodium vivax. The greatest proportions of P. falciparum cases were observed in 2018 and 2019, at 97.4% and 97.0% prevalence, respectively. There was significant seasonal variation in case number, the highest observed in July through September of each year. Climatic conditions of annual rainfall, temperature and humidity favored the increment of malaria cases from June until October.

Conclusion
The study shows that the burden, i.e. morbidity and mortality (with fluctuating patterns) of malaria are still significant public health problems and can pose serious consequences in the district. This has implication for cross-border malaria transmission risk due to considerable border crossings. The predominant cause of the disease is P. falciparum, which causes severe complications in patients. The district has to prepare to deal with such complications for better patient care and outcomes.