bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identifying the regional drivers of influenza-like illness in Nova Scotia, Canada, with dominance analysis
Authors: Aydede Yigit , Ditzen Jan 
Published: June 2023

AbstractThe spread of viral pathogens is inherently a spatial process. While the temporal aspects of viral spread at the epidemiological level have been increasingly well characterized, the spatial aspects of viral spread are still understudied due to a striking absence of theoretical expectations of how spatial dynamics may impact the temporal dynamics of viral populations. Characterizing the spatial transmission and understanding the factors driving it are important for anticipating local timing of disease incidence and for guiding more informed control strategies. Using a unique data set from Nova Scotia, Canada, the objective of this study is to apply a new novel method that recovers a spatial network of the influenza-like viral spread where the regions in their dominance are identified and ranked. We, then, focus on identifying regional predictors of those dominant regions. Our analysis uncovers 18 key regional drivers among 112 regions, each distinguished by unique community-level vulnerability factors such as demographic and economic characteristics. These findings offer valuable insights for implementing targeted public health interventions and allocating resources effectively.
A systematic approach to deep learning-based nodule detection in chest radiographs
Authors: Behrendt Finn , Bengs Marcel , Bhattacharya Debayan , Krüger Julia , Opfer Roland , Schlaefer Alexander 
Published: June 2023

AbstractLung cancer is a serious disease responsible for millions of deaths every year. Early stages of lung cancer can be manifested in pulmonary lung nodules. To assist radiologists in reducing the number of overseen nodules and to increase the detection accuracy in general, automatic detection algorithms have been proposed. Particularly, deep learning methods are promising. However, obtaining clinically relevant results remains challenging. While a variety of approaches have been proposed for general purpose object detection, these are typically evaluated on benchmark data sets. Achieving competitive performance for specific real-world problems like lung nodule detection typically requires careful analysis of the problem at hand and the selection and tuning of suitable deep learning models. We present a systematic comparison of state-of-the-art object detection algorithms for the task of lung nodule detection. In this regard, we address the critical aspect of class imbalance and and demonstrate a data augmentation approach as well as transfer learning to boost performance. We illustrate how this analysis and a combination of multiple architectures results in state-of-the-art performance for lung nodule detection, which is demonstrated by the proposed model winning the detection track of the Node21 competition. The code for our approach is available at https://github.com/FinnBehrendt/node21-submit.
Physicochemical parameters, sensory profile and concentration of volatile compounds and anthocyanins in beers brewed using potato variety with purple flesh
Authors: Gasiński Alan , Kawa-Rygielska Joanna , Kita Agnieszka , Kucharska Alicja 
Published: June 2023

AbstractIn the recent years, beer brewers are experimenting with using various substrates, other than traditional barley malt, water, hops, and yeast for beer production, because new adjuncts to the beer brewing can add new sensory and functional properties to this beverage. Novel potatoes with purple or red-colour flesh are a good and cheap starch source and are rich in bioactive components, which could increase the nutritive value of the produced beer. The aim of the study was to determine whether some part of barley malt can be replaced by the potatoes of purple-colour flesh and assessment of properties of such beer. Beer samples showed increased antioxidant activity, higher concentration of anthocyanins and polyphenol compounds, as well as modified composition of volatiles and lower ethanol content. Beer produced with the addition of 30% of purple potatoes showed acceptable organoleptic qualities in the sensory analysis.
Identification of key biomarkers and related immune cell infiltration in cervical cancer tissue based on bioinformatics analysis
Authors: Zhu Guang , Xiong Zhihui , Chen Wenzeng , Zhu Zhen , Wang Wei 
Published: June 2023

AbstractCervical cancer (CC) is the most common gynecological malignant tumor. Immunotherapy has become a new model for the treatment of CC, especially advanced and recurrent cancer. At present, many studies are exploring the safety and efficacy of immunotherapy for advanced or recurrent CC. In this study, CIBERSORT was used to analyze the immune cell infiltration in CC patients, to evaluate the proportion of immune cell types in CC samples, to quantify the cell composition of the immune response, and to analyze its prognostic value. The expression profile datasets of CC were downloaded from the GEO. The differentially expressed genes (DEGs) between CC and normal cervical tissues were identified via R software (version 4.1.1), and their functions and pathways were enriched and analyzed. A protein–protein interaction network was constructed to screen the hub gene. Immune cell infiltration in CC was analyzed via scientific reverse convolution algorithm (CIBERSORT), and the hub gene was analyzed via survival analysis to screen the diagnostic biomarkers of CC. A total of 144 DEGs and 12 hub genes were identified. DEGs are mainly involved in molecular functions such as serine-peptidase activity, serine-hydrolase activity, and chemokine activity. The enrichment pathway is closely related to the interaction between viral proteins and cytokines and cytokine receptors, the interleukin 17 signaling pathway, and chemokine signaling pathway. The immune cell infiltration analysis showed that T cells were the main infiltrating immune cells in CC, especially T cells CD8+ and CD4+ . The survival analysis of the hub gene showed that CEP55, MCM2, RFC4, and RRM2 had high diagnostic value. CEP55, MCM2, RFC4, and RRM2 can be used as diagnostic markers for CC. CD8+ and CD4+ T cells are closely related to the occurrence and development of CC.
Winter heavy precipitation events over Northern Europe modulated by a weaker NAO variability by the end of the 21st century
Authors: Fuentes-Franco Ramón , Docquier David , Koenigk Torben , Zimmermann Klaus , Giorgi Filippo 
Published: June 2023

AbstractWe use an ensemble of models participating in the Coupled Model Intercomparison Project phase 6 (CMIP6) to analyse the number of days with extreme winter precipitation over Northern Europe and its relationship to the North Atlantic Oscillation (NAO), for the historical period 1950–2014 and two future 21st-century scenarios. Here we find that over Northern Europe, the models project twice more extreme precipitation days by the end of the 21st century under the high-emission scenario compared to the historical period. We also find a weakening of the NAO variability in the second half of the 21st century in the high greenhouse gas emission scenario compared to the historical period, as well as an increasing correlation between extreme winter precipitation events and the NAO index in both future scenarios. Models with a projected decrease in the NAO variability across the 21st century show a positive trend in the number of days with extreme winter precipitation over Northern Europe. These results highlight the role played by NAO in modulating extreme winter precipitation events.
A reusable polymer anchored pyridine mediated formal [4 + 1] annulation reaction for the diastereoselective synthesis of 2,3-dihydrobenzofurans
Authors: Kumari Akanksha , Jain Anshul , Shukla Khyati , Patra Ranjan , Rana Nirmal K. 
Published: June 2023

Merrifield resin supported pyridine is used to generate N-ylide in-situ and is applied as a C1 synthon for the cascade synthesis of trans-2,3-disubstituted dihydrobenzofurans.
Co‐simulation of integrated transmission and distribution systems (ITDS)
Authors: Selvaraj Ajitha , Krishnan Narayanan , Jadoun Vinay Kumar , Sharma Anurag , Sharma Gulshan 
Published: June 2023

AbstractCo‐simulation is an approach where the simulation of both transmission and distribution system gets combined. This approach provides more accurate description of the results which can help the decision making of the operator. Due to increasing rate of decentralization, there is bidirectional energy flow. Thus, getting uninterrupted power supply even under any kind of stressed situation is possible with the help of renewable energy sources (RES), distributed generators (DG) and electric vehicles (EV) in the system. EVs can act as a source and load depending on the discharging or charging characteristics. The power in the EVs can be discharged during stressed hours to manage over loading of transmission lines by avoiding line limit violation. The IEEE 30 bus system is considered as transmission system in which IEEE 33 bus system and IEEE 69 bus system as Micro Grids (MGs) are being integrated at three different buses. Load flow analysis is performed for different cases using MATLAB software. The reduction of MVA flow in the transmission line is observed when it is managed using RES integrated in transmission system while DGs and EVs present within the microgrids.
Large main-belt asteroids are generally not Maclaurin or Jacobi ellipsoids
Authors: Chambat F. , Vermersch J. , Rambaux N. 
Published: June 2023

Aims.A recent major high-angular-resolution imaging survey of 42 large main-belt asteroids (D > 100 km) with VLT/SPHERE has provided shape models of these bodies with an unprecedented accuracy. We ask whether the shapes of these bodies correspond to Maclaurin or Jacobi hydrostatic equilibrium figures.Methods.To address this question, we compared the aspect ratios and rotation rates of these asteroids with Maclaurin or Jacobi equilibrium figures.Results.The rotation rates and polar flattenings of the 42 asteroids globally do not match those of Maclaurin or Jacobi ellipsoids. Moreover, the equatorial axes of the asteroids are not compatible with an axial symmetry as for Maclaurin figures. Only a very few of them could be compatible with a known hydrostatic figure such as Maclaurin, Jacobi, or Clairaut ellipsoids.
VICTORIA project: The LOFAR HBA Virgo Cluster Survey
Authors: Edler H. W. , de Gasperin F. , Shimwell T. W. , Hardcastle M. J. , Boselli A. , Heesen V. , McCall H. , Bomans D. J. , Brüggen M. , Bulbul E. , Chyży K. T. , Ignesti A. , Merloni A. , Pacaud F. , Reiprich T. H. , Roberts I. D. , Rottgering H. J. A. , van Weeren R. J. 
Published: June 2023

Context. The Virgo cluster is the nearest (d = 16.5 Mpc) massive (M ≥ 1014 M⊙) galaxy cluster and is therefore a prime target for studying astrophysical processes in dense large-scale environments. In the radio band, we can probe the nonthermal components of the interstellar medium, the intracluster medium (ICM), and of active galactic nuclei (AGN). This allows an investigation of the impact of the environment on the evolution of galaxies and the contribution of AGN to ICM heating. With the ViCTORIA (VIrgo Cluster multi-Telescope Observations in Radio of Interacting galaxies and AGN) project, we are carrying out multiple wide-field surveys of the Virgo cluster at different frequencies.
Aims. We aim to investigate the impact of the environment on the evolution of galaxies and the contribution of AGN to ICM heating – from the inner cluster regions out to beyond the virial radius.
Methods. We performed a survey of the cluster at 120–168 MHz using the LOw-Frequency ARray (LOFAR). We imaged a 132 deg2 region of the cluster, reaching an order-of-magnitude greater sensitivity than existing wide-field radio surveys of this field at three times higher spatial resolution compared to other low-frequency observations. We developed a tailored data processing strategy to subtract the bright central radio galaxy M 87 from the data. This allowed us to correct for systematic effects due to ionospheric variation as a function of time and direction.
Results. In the final mosaic, which has a resolution of 9″ × 5″, we reach a median noise level of 140 μJy beam−1 inside the virial radius and 280 μJy beam−1 for the full area. We detect 112 Virgo member galaxies and 114 background galaxies. In at least 18 cases, the radio morphology of the cluster member galaxies shows clear signs of ram-pressure stripping. This includes three previously unreported candidates. In addition, we reveal previously undiscovered tails of 150 kpc in length from a previous epoch of AGN activity for NGC 4472 (M 49). While no cluster-scale diffuse radio sources are discovered, we find the presence of an extended radio signature of the W′ group. This feature is coincident with an X-ray filament detected with SRG/eROSITA in the outskirts of the cluster. We speculate that this emission is synchrotron radiation, which could be related to shocks or turbulence from accretion processes.
Conclusions. The data published in this paper serve as a valuable resource for future studies. In the follow-up work of the ViCTORIA project, we will use these data for an analysis of environmental effects on the radio properties of star-forming galaxies in Virgo.
Rhinosinusite chronique idiopathique du chat : démarche diagnostique et options thérapeutiques
Authors: Canonne-Guibert Morgane 
Published: June 2023

La rhinosinusite chronique idiopathique est l’une des principales affections nasales chez le chat. Malgré cette prévalence élevée, il s’agit d’une affection dont la prise en charge thérapeutique à long terme peut s’avérer frustrante. Le plus souvent, les chats concernés sont de jeunes adultes. Cette affection se caractérise essentiellement par des épisodes récurrents de jetage nasal, d’éternuements et de respiration bruyante (stertor).
Le diagnostic de confirmation repose sur l’exclusion des autres maladies des cavités nasales. Dans ce cadre, la réalisation d’examens complémentaire est déterminante et comprend un examen tomodensitométrique, une endoscopie et la réalisation de biopsies nasales. Les études comparant les images scanner de processus tumoraux et de rhinite chronique ont identifié que certains éléments permettent la distinction de ces deux entités.
Le traitement est peu consensuel et frustrant. Aucune option curative n’existe et la prise en charge proposée vise à limiter autant que possible l’expression clinique et à prévenir toute aggravation. Le traitement repose essentiellement sur une corticothérapie orale et/ou inhalée, souvent associée initialement à des antihistaminiques. Les lavages nasaux ou les nébulisations apportent souvent un bénéfice clinique.
Inflammation chronique : l’exploration par la biologie médicale
Authors: Chenal Théo , Trumel Catherine 
Published: June 2023

L’inflammation est un phénomène de défense de l’organisme qui se déclenche à la suite d’une agression (infection, trauma…). Lorsque la réponse de l’organisme est efficace, l’inflammation s’arrête, mais lorsque le stimulus persiste, l’inflammation perdure et peut devenir chronique.
De nombreuses causes impliquant différents mécanismes peuvent être à l’origine d’une inflammation chronique systémique chez le chien et le chat et engendrer des modifications hémato-biochimiques identifiables par des examens de routine.
Le dosage des concentrations des protéines de la phase aiguë de l’inflammation permet de mettre en évidence la présence d’une inflammation systémique. L’augmentation de leur concentration plasmatique identifie alors un processus inflammatoire, mais ne renseigne en aucun cas sur la durée d’évolution ou sur sa cause.
L’hémogramme couplé à l’observation du frottis sanguin peut mettre en évidence la présence d’une anémie normocytaire normochrome non régénérative et de rouleaux d’hématies. Une lymphocytose associée à l’observation de lymphocytes réactionnels peut orienter également vers un processus inflammatoire chronique.
Enfin, l’observation d’un pic polyclonal en région β−γ sur un tracé d’électrophorèse des protéines sériques est un témoin relativement spécifique d’une inflammation chronique.
Correlation of Cervical Length, Anterior Uterocervical Angle, and Cervical Elastography with the Incidence of Preterm Labor
Authors: Natarajan Sumathi , Alavandar Ezhilmathi , Kashyap Ravindar , Rajan Saira , Muthusamy Dhivakar , Subramani Amuthavalli 
Published: June 2023

Abstract
Objectives The aim of this study is to find the correlation of cervical length, anterior uterocervical angle, and cervical elastography with the incidence of preterm labor through evaluation by transvaginal ultrasonography during routine anomaly scan and to analyze the correlation of the parameters with each other.
Methods Cross-sectional comparative study was undertaken on singleton pregnant women coming for anomaly scan between 18 and 24 weeks. Cervical length and anterior uterocervical angle were measured in the mid-sagittal section. Strain elastography was used for measuring cervical strain. Color map was obtained for the entire cervix and the color code for the degree of cervical stiffness was noted.
Results Though the mean value of cervical length was significantly lower in preterm group (3.2 cm) than in term group (3.6 cm), it was more than the cutoff value of 2.5 cm, below which it is routinely considered as short cervix indicative of preterm labor. Mean value of anterior uterocervical angle was significantly higher in women with preterm (112.3 degrees) delivery than those with term (82.2 degrees) delivery. Mean strain values of cervical elastography were significantly different in term (0.130) and preterm groups (0.179). Color code in elastography was independent of preterm labor. There was a significant positive correlation of cervical length with gestational age at delivery (GAD). A significant negative correlation was observed between acute anterior uterocervical angle with the GAD.
Conclusion Anterior uterocervical angle has a definitive role in the prediction of preterm labor and so it can be combined with the conventional cervical length screening in identifying women with normal cervical length who are at high risk of preterm labor. Cervical elastography assesses the cervical consistency and also has the potential for identifying high-risk women.
A Rare Case of Dacryocystocele Diagnosed by Antenatal Ultrasonography at 26 Weeks of Gestation
Authors: Ganesan Parvathy , Balakrishnan Bijoy K. , Parasuram Meenu Batra 
Published: June 2023

AbstractDacryocystocele is a rare variant of obstruction of the nasolacrimal duct that results in a fluid-filled, closed sac. It often resolves by the spontaneous perforation of the distal membrane during the early neonatal period, resulting in drainage of the accumulated fluid. If persisting, this benign condition can be usually treated postnatally. If the cysts occur bilaterally, there can be an obstruction to the nasal passage due to their possible intranasal extension and might require surgical intervention postnatally to prevent or treat respiratory distress. Also, it may be a part of a few syndromes, which makes the early prenatal diagnosis very important. In this case report, we present a case of unilateral dacryocystocele reported as early as 26 weeks, 3 days of gestation detected by ultrasound that spontaneously resolved by 33 weeks. This is one of the earliest reported three-dimensional/four-dimensional ultrasound diagnosis of dacryocystocele.
Congenital Cataract and Narrow CSP: A Clue to Prenatal Diagnosis of RAB3GAP1-Associated Warburg Micro Syndrome
Authors: Lallar Meenakshi , Kaur Ladbans , Preet Meetan , Singh U. P. 
Published: June 2023

AbstractWarburg Micro Syndrome (WMS) is an autosomal recessive disorder characterized by intellectual disability, bilateral congenital cataracts, microphthalmia, and brain anomalies. We report an 18-week fetus presenting with bilateral congenital cataract and narrow cavum septum pellucidum. Patient was counselled about the possible etiologies ranging from infectious to chromosomal and single gene etiologies. Invasive testing for genetic analysis was done to determine etiology and establish prognosis. A previously reported homozygous frameshift mutation was identified in RAB3GAP1 gene leading to diagnosis of WMS. This case highlights the role of detailed fetal sonography and genetic testing to prognosticate pregnancies. Also WMS should be suspected in fetuses presenting with bilateral congenital cataract with or without brain anomalies.
Recurrent Nonimmune Fetal Hydrops Due to a Novel Pathogenic Variant in PIEZO1 Gene: A Case Report from South India
Authors: Nair Lekshmi Sivaraman , Dubey Aditi , Mohan Nisha , Vikraman Seneesh Kumar , Desai Jay , Madadi Manasa 
Published: June 2023

AbstractNonimmune fetal hydrops (NIFH) has underlying diverse etiology with generalized lymphatic dysplasia being one such cause. Lymphatic malformation-6 is a type of lymphatic dysplasia that is due to homozygous or compound heterozygous variants in the PIEZO1 gene. The clinical features associated with this condition during fetal life are nonimmune fetal hydrops that manifests with widespread lymphatic edema, with other systemic manifestations like pericardial/pleural effusions, chylothorax along with lymphangiectasia seen primarily in lungs and intestines. We present a case of recurrent NIFH in a family due to a novel pathogenic mutation in PIEZO1 gene. This variant was identified in homozygous state in all the three affected fetuses and in heterozygous state in both the parents. The couple were counseled regarding recurrence of this condition and given reproductive options for future pregnancies.
Kinship analysis reveals low dispersal in a hog deer (Axis porcinus) population in Wilsons Promontory National Park, Australia
Authors: Hill Erin , Murphy Nicholas , Linacre Adrian , Toop Simon , Strugnell Jan M. 
Published: June 2023

Context A wild population of non-native hog deer has established in the Gippsland region of Victoria, Australia, and there is particular concern about its impact on native vegetation in Wilsons Promontory National Park (WPNP). Since 2015, there has been annual culling of hog deer at WPNP to reduce deer abundances and impacts. Aims The aims of this study were to use a kinship approach based on genotyping to assess contemporary dispersal of hog deer across WPNP, by identifying close kin, to determine whether dispersal of deer into culled sites from unculled sites may affect the long-term success of management there. Differences in the dispersal of male and female hog deer were also investigated. Methods In total, 91 hog deer tissue samples were collected across WPNP and surrounding sites. Single nucleotide polymorphism (SNP) markers were sequenced, and a final dataset comprising 8275 SNPs was used for analysis. First-order, second-order, and intermediate relative pairs were identified, and the geographic distance between these pairs was assessed to determine inter-pair distances to infer dispersal. Spatial autocorrelation between male and female samples was evaluated to measure the effects of sex-biased dispersal. Key results Only seven second-order relative pairs were found across different sites, with a 30 km distance between the furthest pair observed. However, most inter-pair distances across sites were ~5–10 km. Analyses of sex-biased dispersal showed that movement by deer was not strongly influenced by one sex. Conclusions Although hog deer in WPNP are genetically similar, most relatives that were sampled were not widely dispersed. This suggests that there is limited dispersal of hog deer across this park. Implications Recolonisation of hog deer at culled sites via dispersal is likely to be infrequent in WPNP. Kinship analysis provides an effective method of assessing contemporary dispersal and could be applied to other species to assess fine-scale movement across landscapes.