bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of maintenance dose of eptifibatide in patients with ST-segment elevation myocardial infarction who underwent primary percutaneous coronary intervention
Authors: Jalalian Rozita , Bagheri Babak , Yazdani Charati Jamshid , Khalaghi Shahrnaz , Iranian Mohammadreza , Mohammadi Mahsa 
Published: April 2023

AbstractBackgroundST-segment elevation myocardial infarction (STEMI) is usually caused by a rupture in the atherosclerotic plaque, followed by platelet aggregation which ultimately leads to acute coronary artery occlusion. So far, few studies have investigated the effect of maintenance dose of Eptifibatide (glycoprotein IIb/IIIa inhibitor) in STEMI patients who underwent primary percutaneous coronary intervention (PPCI). Therefore, in this study, we investigated the effect of maintenance dose of Eptifibatide in patients with STEMI who underwent PPCI. 264 patients who had acute chest pain suggestive of STEMI were entered in the study. All patients received the same dose of bolus dose of Eptifibatide in the cardiac catheterization laboratory. Then the patients were randomly divided into two groups, one group (n = 147) received a maintenance dose of intravenous Eptifibatide (infusion of 2 μg/kg/min) and the other group (n = 117) did not receive this treatment. Standard medical treatment of STEMI after PPCI was performed based on guidelines and the same in both groups. All patients were evaluated 1, 2, and 3 months after the start of treatment in terms of predicted outcomes.ResultsThe occurrence of 3-month major adverse cardiovascular events (MACE) between the case and control groups did not have a statistically significant difference (28.6% versus 35.0%;Pvalue: 0.286). Also, investigations showed that the rate of re-infarction (Pvalue: 0.024) and target lesion revascularization (Pvalue: 0.003) was significantly lower in the group that received Eptifibatide infusion.ConclusionsEptifibatide maintenance dose infusion in patients who undergo PPCI in the context of STEMI, does not significantly reduce MACE, although it does significantly reduce re-infarction and target lesion revascularization. It also does not increase the risk of bleeding and cerebrovascular events.
CD95/Fas ligand mRNA is toxic to cells through more than one mechanism
Authors: Haluck-Kangas Ashley , Fink Madelaine , Bartom Elizabeth T. , Peter Marcus E. 
Published: April 2023

AbstractCD95/Fas ligand (CD95L) induces apoptosis through protein binding to the CD95 receptor. However, CD95L mRNA also induces toxicity in the absence of CD95 through induction of DISE (Death Induced by Survival Gene Elimination), a form of cell death mediated by RNA interference (RNAi). We now report that CD95L mRNA processing generates a short (s)RNA nearly identical to shL3, a commercial CD95L-targeting shRNA that led to the discovery of DISE. Neither of the miRNA biogenesis proteins Drosha nor Dicer are required for this processing. Interestingly, CD95L toxicity depends on the core component of the RISC, Ago2, in some cell lines, but not in others. In the HCT116 colon cancer cell line, Ago 1–4 appear to function redundantly in RNAi. In fact, Ago 1/2/3 knockout cells retain sensitivity to CD95L mRNA toxicity. Toxicity was only blocked by mutation of all in-frame start codons in the CD95L ORF. Dying cells exhibited an enrichment of RISC bound (R)-sRNAs with toxic 6mer seed sequences, while expression of the non-toxic CD95L mutant enriched for loading of R-sRNAs with nontoxic 6mer seeds. However, CD95L is not the only source of these R-sRNAs. We find that CD95L mRNA may induce DISE directly and indirectly, and that alternate mechanisms may underlie CD95L mRNA processing and toxicity.
A contribution to understanding blue carbon sequestration and forest structure in mangroves of different ages in a small island (Mauritius)
Authors: Ramdhun Devesee , Appadoo Chandani 
Published: April 2023

Abstract. Ramdhun D, Appadoo C. 2020. A contribution to understanding blue carbon sequestration and forest structure in mangroves of different ages in a small island (Mauritius). Ocean Life 4: 74-81. Mangrove biomes, a blue carbon coastal ecosystem, are considered as the most carbon-rich forest in the tropics, but there is a knowledge gap on their ecosystem services especially in small islands. The purpose of this study was to evaluate the carbon stock in sediment and aboveground biomass of three different ages of Rhizophora mucronata forests along the coastline of Mauritius. Forest structure was assessed, and measurements of diameter at breast height were used to calculate biomass using allometric equation. Corer samples were collected in each site and sectioned into subsamples of 0-10 cm, 10-20 cm and 20-30 cm, to analyze soil bulk density and soil organic carbon. The highest SOC stock (470.08 t ha?¹) was recorded at Mahebourg and lowest (331.33 t ha?¹) in the young stand at Le Morne. The total organic carbon contents varied from 931.50±17.06 t ha?¹ (at Mahebourg) to 350.76±4.058 t ha?¹ (young forest at Le Morne). There was no significant difference in soil carbon density at different soil depths studied at Le Morne (n=81, p=0.430 (old forest), p=0.875 (young forest)), however, a different scenario was observed at Mahebourg (n=81, p=0.027). This study is the first to report on the potential of carbon storage at these sites in Mauritius and add to the knowledge of the ecosystem services of this ecosystem.
Estimation of aboveground biomass and carbon stock in Damas Beach, Trenggalek District, East Java, Indonesia
Authors: NUR ALYA AFRA INAS , ARIFIANI KIRANA NURUL , RAMADHANDI ANANDA RILO , SABRINA AGRA DEWI , NUGROHO GILANG DWI , KUSUMANINGRUM LIA , RAMDHUN DEVESEE , BAO TRAN QUANG , YAP CHEE KONG , BUDIHARTA SUGENG , SETYAWAN AHMAD DWI 
Published: April 2023

Abstract. Nur AAI, Arifiani KN, Ramadhandi AR, Sabrina AD, Nugroho GD, Kusumaningrum L, Ramdhun D, Bao TQ, Yap CK, Budiharta S, Setyawan AD. 2022. Estimation of aboveground biomass and carbon stock in Damas Beach, Trenggalek District, East Java, Indonesia. Indo Pac J Ocean Life 6: 103-109. Vegetation plays a vital role in providing environmental services in the form of storing carbon which can mitigate climate change. This study aimed to calculate Aboveground Biomass (AGB) and carbon stock in Damas Beach, Trenggalek District, East Java Province, Indonesia using an allometric equation. Biomass and carbon data at a tree (dbh >20 cm) and pole (dbh 10-20 cm) levels were collected using sampling plots distributed randomly at three stations, namely mangrove vegetation (Station I), coconut plantation (Station II), and agroforestry (Station III). The results showed that across the three research stations, there were a total of 23 plant species classified as tree and pole levels. At tree level, Rhizophora stylosa Griffith had the highest carbon stock with a value of 85.48 MgC/ha, while the lowest value was Nypa fruticans Wurmb with 0.02 MgC/ha. Similarly, at the pole level, the species with the highest carbon stock was R. stylosa, with a value of 65.88 MgC/ha, and the lowest was Theobroma cacao L. with 0.11 MgC/ha. The mangrove vegetation (Station I) had the highest carbon stock value of 200.53 MgC/ha. In contrast, the coconut plantation vegetation (Station II) has the lowest total carbon stock, with a value of 84.68 MgC/ha. Conservation and management need to be improved in the Damas Beach area because if the area is disturbed, the ability of vegetation to absorb carbon will decrease.
Generic properties of the Rabinowitz unbounded continuum
Authors: Bartolucci Daniele , Hu Yeyao , Jevnikar Aleks , Yang Wen 
Published: April 2023

Abstract
In this article, we prove that, generically in the sense of domain variations, any solution to a nonlinear eigenvalue problem is either nondegenerate or the Crandall-Rabinowitz transversality condition that is satisfied. We then deduce that, generically, the unbounded Rabinowitz continuum of solutions is a simple analytic curve. The global bifurcation diagram resembles the classic model case of the Gel’fand problem in two dimensions.
NUDT21 relieves sevoflurane-induced neurological damage in rats by down-regulating LIMK2
Authors: Zhong Yuanping , Zhao Pengcheng , Zhang Chao , Wu Zhenyu , Fang Xu , Zhu Zhaoqiong 
Published: April 2023

Abstract
Postoperative cognitive dysfunction (POCD) is a common complication of cognitive decline after surgery and anesthesia. Sevoflurane, as a commonly used anesthetic, was found to cause POCD. Nudix Hydrolase 21 (NUDT21), a conserved splicing factor, has been reported to exert important functions in multiple diseases’ progression. In this study, the effect of NUDT21 on sevoflurane-induced POCD was elucidated. Results showed that NUDT21 was down-regulated in the hippocampal tissue of sevoflurane-induced rats. Morris water maze test results revealed that overexpression of NUDT21 improved sevoflurane-induced cognitive impairment. In addition, TUNEL assay results indicated that enhanced NUDT21 alleviated sevoflurane-induced apoptosis of hippocampal neurons. Furthermore, overexpression of NUDT21 suppressed the sevoflurane-induced LIMK2 expression. Taken together, NUDT21 alleviates sevoflurane-induced neurological damage in rats by down-regulating LIMK2, providing a novel target for the prevention of sevoflurane-induced POCD.
Interaction between the PI3K/AKT pathway and mitochondrial autophagy in macrophages and the leukocyte count in rats with LPS-induced pulmonary infection
Authors: Wu Chao , Guo Lianghua , Muhataer Xirennayi , Li Qifeng , Lian Zhichuang , Li Yafang , Wang Wenyi , Ding Wei , Zhou Yuan , Yang Xiaohong , Chen Muzhi 
Published: April 2023

Abstract
This study examined the effects of the PI3K/AKT pathway and mitochondrial autophagy in macrophages and the leukocyte count after pulmonary infection. Sprague‒Dawley rats were subjected to tracheal injection of lipopolysaccharide (LPS) to establish animal models of pulmonary infection. By inhibiting the PI3K/AKT pathway or inhibiting/inducing mitochondrial autophagy in macrophages, the severity of the pulmonary infection and the leukocyte count were altered. The PI3K/AKT inhibition group did not show a significant difference in leukocyte counts compared with the infection model group. Mitochondrial autophagy induction alleviated the pulmonary inflammatory response. The infection model group had significantly higher levels of LC3B, Beclin1, and p-mTOR than the control group. The AKT2 inhibitor group exhibited significantly increased levels of LC3B and Beclin1 compared with the control group (P < 0.05), and the Beclin1 level was significantly higher than that in the infection model group (P < 0.05). Compared with the infection model group, the mitochondrial autophagy inhibitor group exhibited significantly decreased levels of p-AKT2 and p-mTOR, whereas the levels of these proteins were significantly increased in the mitochondrial autophagy inducer group (P < 0.05). PI3K/AKT inhibition promoted mitochondrial autophagy in macrophages. Mitochondrial autophagy induction activated the downstream gene mTOR of the PI3K/AKT pathway, alleviated pulmonary inflammatory reactions, and decreased leukocyte counts.
Sterols from Centaurea pumilio L. with cell proliferative activity: In vitro and in silico studies
Authors: Fayed Marwa A. A. , Al-Wahaibi Lamya H. , Bakr Riham O. , Nour Mai S. , Basudan Omer A. , Parvez Mohammad K. , Al-Dosari Mohammed S. , Abdel-Mageed Wael M. 
Published: April 2023

Abstract
Numerous studies highlighted the impact of natural products, particularly phytosterols, in wound healing while providing less expensive alternatives to chemically synthesized drugs, with less side effects. Centaurea pumilio L. (family Asteraceae) is a rare and endangered species of genus Centaurea with few reports concerning its chemistry. Our phytochemical investigation for the non-polar fraction of its aerial parts led to the isolation and identification of the new compound (6) identified as stigmast-1,5-dien-3-O-β-d-glucopyranoside along with five known sterols and triterpenes (1–5) identified as taraxasterol, β-sitosterol, stigmasterol, β-sitosterol glucoside, and stigmasterol-3-O-β-d-glucopyranoside. Structures of the isolated compounds have been characterized using 1D, 2D NMR, and mass spectral analyses. The cell viability and proliferative activity of the isolated compounds were evaluated using an MTT assay on cultured human primary umbilical vein endothelial cells (HUVEC). None of the compounds exhibited any sign of cytotoxicity. Nonetheless, compounds 5 and 6 moderately enhanced the HUVEC cell growth by 14 and 16%, respectively, at the maximal tested dose (50 µg/mL). As inhibition of glycogen synthase kinase 3-β (GSK3-β) enzyme is important to enhance the wound healing process; therefore, molecular docking was performed to understand the possible interactions between bioactive compounds 5 and 6 and GSK-3β binding pocket active amino acid residues. Both compounds were able to bind to the substrate‑binding site of GSK-3β and potentially interact with the key active site residues, forming strong π and hydrogen interactions with the catalytic site residues, revealing lower binding energy (−7.185 and −6.303 kcal/mol, respectively) than that of indirubin-3-monooxime (−5.303 kcal/mol); thereby representing strong natural replacements candidates for GSK-3β inhibitors.
Performance audit evaluation of marine development projects based on SPA and BP neural network model
Authors: Gao Sheng , Sun Huihui , Huang Xiaoyan , Hui Yu , Ge Shutong 
Published: April 2023

Abstract
Accurately grasping the comprehensive cost-benefit and influencing factors of various marine development projects is of great significance to the promotion of high-quality marine development. This work screened and constructed the performance audit evaluation index system of comprehensive cost-benefit of marine development projects from the four aspects including society, economy, resources, and environment. The entropy weight set pair analysis (SPA) was used to audit and evaluate the comprehensive cost-benefit of 15 marine development projects during the construction and operation period. The back propagation (BP) neural network model was used to test the results. The main influencing factors were analyzed by the grey relational analysis (GRA) model. It was found that the comprehensive cost-benefit performance audit evaluation index of the six projects of marine protected area and offshore wind power were higher than the other nine projects of mariculture, sewage dumping, and port industry. The main influencing factors were economic net income, loss of wetland ecological service value, environmental pollution prevention and control cost, new addition employment rate, etc. The countermeasures suggestions were put forward.
Evaluation of nano-selenium biofortification characteristics of alfalfa (Medicago sativa L.)
Authors: Sun Pengbo , Wang Zhijun , Yuan Ning , Lu Qiang , Sun Lin , Li Yuyu , Zhang Jiawei , Zhang Yuhan , Ge Gentu , Jia Yushan 
Published: April 2023

Abstract
Selenium (Se) is indispensable for animals and humans. One option to address Se deficiency is to biofortify plants with Se. Biofortification of forage with Se nanoparticles (NPs) is gaining more attention as an efficient and safe source of Se for livestock. The purpose of this study was to investigate the effect of different concentrations of NPs-Se (0, 30, 50, 100, 150, and 250 mg·L−1) on the growth of alfalfa harvested multiple times, and to provide a basis for the production of Se-enriched forages. Applying 50 mg·L−1 concentration of NPs-Se had the best effect on yield over three harvests. Over three harvests, low-dose NPs-Se (30 and 50 mg·L−1) application significantly increased peroxidase and superoxide dismutase activities, chlorophyll content and carotenoid content, and significantly decreased malondialdehyde content. The total Se content and Se accumulation in plants at the same harvest showed an upward trend with increasing Se concentration. At the same concentration, from first harvest to third harvest, Se content and Se accumulation showed an initially increasing and then decreasing trend. The evaluation found that foliar application of NPs-Se at 50 mg·L−1 could have the greatest positive effect on the growth and yield of multiple-harvested alfalfa.
Synthesis and conformational analysis of N-BOC-protected-3,5-bis(arylidene)-4-piperidone EF-24 analogs as anti-cancer agents
Authors: Smith Robert B. , Roberts William , Upenieks Mary , Gibson Maya Z. , Wentzel Michael T. , Grice Kyle A. , Zingales Sarah K. 
Published: April 2023

Abstract
Natural products and their analogs have been explored to stop the progression of cancer cells without unwanted side effects. Chalcones, compounds synthesized naturally in plants, have demonstrated potential as anti-cancer treatments. A library of bis-chalcones that are similar in structure to EF-24, a bis-chalcone molecule known to have anti-cancer properties, has been synthesized in order to examine their medicinal properties. This report highlights the synthesis of ten novel analogs, their anti-cancer activities, and conformational analysis via cryo-NMR and corroboration by density functional theory calculations of the lead compound 1b, tert-butyl 3,5-bis((E)-4-methylbenzylidene)-4-oxopiperidine-1-carboxylate.
Intelligent identification algorithm and key point detection of abnormal vibration of transmission tower based on machine learning
Authors: Hong Huawei , Wu Kaibin , Yue Mengmeng , Dai An 
Published: April 2023

Abstract
In some special geological areas, the inclination and displacement of transmission line towers are relatively common, which should be analyzed from various factors. Transmission towers are the support structure for overhead transmission lines and play a pivotal role in the safe operation of the power grid. Transmission lines are widely distributed. Transmission poles and towers are generally built in areas with poor geological conditions such as goaf, river bed and slope. Under severe weather conditions, the force on the tower may be affected to a certain extent, causing the tower to tilt, deform, or even collapse, and thus causing a wide range of power system failures, which have a great impact on people’s production and life. Based on this objective problem, this paper has mainly studied the intelligent recognition methods and key technologies based on machine learning. In the experimental study of support vector machine (SVM) model based on machine learning, the average training time of genetic algorithm support vector regression (GA-SVR) was the longest, reaching 1.462 s. The average training duration of double chain quantum genetic algorithm-least squares support vector regression (DCQGA-LSSVR) was the shortest, with 0.156 s. The average pose error of double chain quantum genetic algorithm-support vector regression (DCQGA-SVR) was the smallest, only 0.136, while the average attitude error of genetic algorithm-least squares support vector regression (GA-LSSVR) was the highest, reaching 0.45. Therefore, it is of the great significance to analyze abnormal vibration of the transmission towers based on machine learning method.
Coexistence of Graves’ disease with acute rheumatic fever treated as thyroid storm in young Thai patient
Authors: Onsoi Witchuwan , Srilanchakon Khomsak , Aroonparkmongkol Suphab , Supornsilchai Vichit 
Published: April 2023

Abstract

Objectives
This report presents a case of acute onset of chorea, concurrent Graves’ disease, and acute rheumatic fever in an 8-year-old female patient.

Case presentation
The child had intermittent involuntary movement of all extremities and both eyes for 4 days, with a previous history of increased appetite, weight lost, and heat intolerance over a period of two months. Physical examination revealed fever, tachycardia, exophthalmos, eyelid retraction, as well as diffused thyroid enlargement. Initial clinical features and thyroid function testing suggested a thyroid storm due to Graves’ disease. Methimazole, propranolol, potassium iodide (SSKI), and dexamethasone were prescribed. Congestive heart failure developed after propranolol and cardiovascular re-evaluation and Revised Jones criteria suggested acute rheumatic fever. Chorea was successfully treated with pulse methylprednisolone.

Conclusions
We reported Graves’ disease patients with acute rheumatic fever simulating a thyroid storm. The underlying cardiac disease must be considered, especially where chorea and congestive heart failure are present.
Prevalence of nonalcoholic fatty liver disease increased with type 2 diabetes mellitus in overweight/obese youth with polycystic ovary syndrome
Authors: Patel-Sanchez Namrata , Perito Emily , Tsai Patrika , Raymond-Flesch Marissa , Lodish Maya , Sarkar Monika 
Published: April 2023

Abstract

Objectives
Polycystic ovary syndrome (PCOS) increases non-alcoholic fatty liver disease (NAFLD) risk and severity in adults, but data in adolescents with diverse backgrounds are limited. We evaluated NAFLD prevalence and characterized NAFLD risk factors in overweight/obese adolescents by PCOS status.

Methods
Retrospective study of overweight (n=52)/obese (n=271) female adolescents (12–18 years old), evaluated clinically 2012–2020, was conducted comparing PCOS patients to age-matched non-PCOS controls. NAFLD was defined as ALT≥44U/L x2 and/or ≥80U/L x1, hepatic steatosis on imaging, or NAFLD on biopsy, in absence of other liver disease. Metabolic comorbidities were captured. Log-binomial regression models estimated prevalence risk ratios (PR).

Results
NAFLD prevalence was 19.1 % in adolescents with PCOS (n=161), similar to those without (n=162) (16.8 %, p=0.6). Adolescents with PCOS were more likely to have insulin resistance, hypercholesterolemia, and higher triglycerides (p<0.05). Those with PCOS and concomitant type 2 diabetes (T2DM) did have increased NAFLD risk (PR 2.5, p=0.04), but those with PCOS without T2DM did not (PR 0.9, p=0.8). Adolescents with PCOS and NAFLD, compared to those with PCOS without NAFLD, had a higher prevalence of metabolic comorbidities including hypercholesterolemia (77 vs. 48 %), T2DM (29 vs. 8 %), and hypertriglyceridemia (65 vs. 37 %) (p<0.01).

Conclusions
Almost 1 in 5 overweight/obese female adolescents had NAFLD, but PCOS did not increase NAFLD risk in this diverse cohort. Among young women with PCOS, concomitant T2DM did increase the risk for NAFLD. Closer monitoring of obesity comorbidities in adolescents with PCOS is essential for optimizing health and merits updating current guidelines.
Localising INGOs websites into Arabic: A case study of IFRC
Authors: Sayaheen Bilal , Darwish Ibrahim 
Published: April 2023

Abstract
The present study aims to compare and contrast the websites of international non-government organizations (INGOs) that make their websites available in Jordan in both Arabic and English with the purpose of identifying the content that does or does not get localised. The researchers selected the website of the International Federation of Red Cross and Red Crescent Societies (IFRC) as a case study. The English version of the IFRC website is meticulously set off against its Arabic counterpart. This study draws on Olvera-Lobo and Castillo-Rodríguez’s (2019) suggested framework with regards to the linguistic and cultural aspects of localised websites. The study concludes that the recommendations related to linguistic and cultural aspects of website localisation presented by Olvera-Lobo and Castillo-Rodríguez (2019) have proven to be valuable in assessing the localised versions of INGOs as they cover a wide range of facets needed by the target readerships.