bluuebunny/crossref_metadata_2025_split huggingface dataset:
M100 ExaData: a data collection campaign on the CINECA’s Marconi100 Tier-0 supercomputer
Authors: Borghesi Andrea , Di Santi Carmine , Molan Martin , Ardebili Mohsen Seyedkazemi , Mauri Alessio , Guarrasi Massimiliano , Galetti Daniela , Cestari Mirko , Barchi Francesco , Benini Luca , Beneventi Francesco , Bartolini Andrea 
Published: May 2023

AbstractSupercomputers are the most powerful computing machines available to society. They play a central role in economic, industrial, and societal development. While they are used by scientists, engineers, decision-makers, and data-analyst to computationally solve complex problems, supercomputers and their hosting datacenters are themselves complex power-hungry systems. Improving their efficiency, availability, and resiliency is vital and the subject of many research and engineering efforts. Still, a major roadblock hinders researchers: dearth of reliable data describing the behavior of production supercomputers. In this paper, we present the result of a ten-year-long project to design a monitoring framework (EXAMON) deployed at the Italian supercomputers at CINECA datacenter. We disclose the first holistic dataset of a tier-0 Top10 supercomputer. It includes the management, workload, facility, and infrastructure data of the Marconi100 supercomputer for two and half years of operation. The dataset (published via Zenodo) is the largest ever made public, with a size of 49.9TB before compression. We also provide open-source software modules to simplify access to the data and provide direct usage examples.
Comprehensive evaluation of zeolite/marine alga nanocomposite in the removal of waste dye from industrial wastewater
Authors: Hamd Ahmed , Shaban Mohamed , Al-Senani Ghadah M. , Alshabanat Mashael N. , Al-Ghamdi Azza , Dryaz Asmaa Ragab , Ahmed Sayed A. , El-Sayed Refat , Soliman N. K. 
Published: May 2023

AbstractA systematic study integrating laboratory, analytical, and case study field trial was conducted to figure out the effective adsorbent that could be used for the removal of Congo red (CR) dye from industrial wastewater effluent. The ability of the zeolite (Z) to adsorb CR dye from aqueous solutions was evaluated after it was modified by the Cystoseira compressa algae (CC) (Egyptian marine algae). Zeolite, CC algae were combined together in order to form the new composite zeolite/algae composite (ZCC) using wet impregnation technique and then characterized by the aid of different techniques. A noticeable enhancement in the adsorption capacity of newly synthesized ZCC was observed if compared to Z and CC, particularly at low CR concentrations. The batch style experiment was selected to figure out the impact of various experimental conditions on the adsorption behavior of different adsorbents. Moreover, isotherms and kinetics were estimated. According to the experimental results, the newly synthesized ZCC composite might be applied optimistically as an adsorbent for eliminating anionic dye molecules from industrial wastewater at low dye concentration. The dye adsorption on Z and ZCC followed the Langmuir isotherm, while that of CC followed the Freundlich isotherm. The dye adsorption kinetics on ZCC, CC, and Z were agreed with Elovich, intra-particle, and pseudo-second-order kinetic models, correspondingly. Adsorption mechanisms were also assessed using Weber's intraparticle diffusion model. Finally, field tests showed that the newly synthesized sorbent has a 98.5% efficient in eliminating dyes from industrial wastewater, authorizing the foundation for a recent eco-friendly adsorbent that facilitate industrial wastewater reuse.
Risk factors associated with football injury among male players from a specific academy in Ghana: a pilot study
Authors: Kwakye Samuel Koranteng , Mostert Karien , Garnett Daniel , Masenge Andries 
Published: May 2023

AbstractThere seems to be no information on the incidence of injury and associated risk factors for academy football players in Ghana. We determine the risk factors associated with match and training injuries among male football players at an academy in Ghana. Preseason measurements of players’ height, weight, and ankle dorsiflexion (DF) range of motion (ROM) were measured with a stadiometer (Seca 213), a digital weighing scale (Omron HN-289), and tape measure, respectively. The functional ankle instability (FAI) of players was measured using the Cumberland Ankle Instability Tool (CAIT), and dynamic postural control was measured with the Star Excursion Balance Test. Injury surveillance data for all injuries were collected by resident physiotherapists throughout one season. Selected factors associated with injury incidence were tested using Spearman’s rank correlation at a 5% significance level. Age was negatively associated with overall injury incidence (r = − 0.589, p = 0.000), match (r = − 0.294, p = 0.008), and training incidence (r = − 0.314, p = 0.005). Previous injury of U18s was associated with training injuries (r = 0.436, p = 0.023). Body mass index (BMI) was negatively associated with overall injury incidence (r = − 0.513, p = 0.000), and training incidence (r = − 0.395, p = 0.000). CAIT scores were associated with overall injury incidence (n = 0.263, p = 0.019) and match incidence (r = 0.263, p = 0.029). The goalkeeper position was associated with match incidence (r = 0.241, p = 0.031) while the U16 attacker position was associated with training incidence. Exposure hours was negatively associated with overall injury incidence (r = − 0.599, p = 0.000). Age, BMI, previous injury, goalkeeper and attacker positions, ankle DF ROM, and self-reported FAI were associated with injury incidence among academy football players in Ghana.
The influence of tourism and hospitality students’ perceived effectiveness of outcome-based education on their VUCA skills
Authors: Guo Yanbing , Zhao Qiaoyan , Cao Zhe , Huang Shaosheng 
Published: May 2023

AbstractThe mismatch between supply and demand in the tourism and hospitality labor markets becomes increasingly serious in the past few years. The main reason for such a problem is that tourism and hospitality students are equipped with academic knowledge but lack VUCA skills. VUCA are the acronyms of volatility, uncertainty, complexity, and ambiguity. However, little research has explored the antecedent mechanism of tourism and hospitality students’ VUCA skills. Hence, the purpose of the present study is to clarify the leading factors that would enhance tourism and hospitality students’ perceived VUCA skills. This study collected data by distributing questionnaires to senior students majoring in tourism and hospitality management (THM) from five universities in China. The results show: First, students’ perceived the effectiveness of outcome-based education (PEOBE) has a significant effect on their perceived VUCA skills and self-concept including cognitive self-concept (CSC) and affective self-concept (ASC). Second, THM students’ CSC is positively related to their perceived VUCA skills. Finally, the relevance of ASC and students’ perceived VUCA skills was not significant. The present study further justified that PEOBE is the prepositive variable of THM students’ cognitive self-concept, supporting the linkage effect of “PEOBE → CSC → self-efficiency → perceived VUCA skills”. From the practical implications, this study focuses on OBE as the entry point to explore the antecedent mechanism of THM students’ perceived VUCA skills, supplying a basic formulation of educational reform policies for the administrative department of higher education around the world.
Prevalence and clinical correlates of abnormal lipid metabolism in first-episode and drug-naïve patients with major depressive disorder with abnormal glucose metabolism
Authors: Zhu Quanfeng , Jiang Guojun , Lang XiaoE , Fu Zhengchuang , Zhang Peng , Zheng Yali , Zhang Xiangyang 
Published: May 2023

AbstractComorbid glucose metabolism abnormalities are very common in patients with major depressive disorder (MDD), and glucose metabolism and lipid metabolism are closely related. However, there are few researches on the incidence and related factors of lipid metabolism abnormalities among MDD patients with comorbid glucose metabolism abnormalities. A cross-sectional study involving 1718 first-episode and drug-naïve (FEDN) MDD patients was conducted. The 17-item Hamilton Depression Scale (HAMD-17), Hamilton Anxiety Rating Scale (HAMA) and Positive and Negative Syndrome Scale (PANSS) positive subscale were utilized to evaluate depressive, anxiety and psychotic symptom, respectively. Serum thyroid function-related parameters, glucose- and lipid-metabolism parameters were measured. The prevalence of abnormal lipid metabolism was significantly higher in FEDN MDD patients with abnormal glucose metabolism than in those without abnormal glucose metabolism (P < 0.001). In MDD patients with abnormal glucose metabolism, TSH, FT3 and body mass index (BMI) levels were significantly higher in the abnormal lipid metabolism subgroup than in the non-abnormal lipid metabolism subgroup. Binary logistic regression analysis showed that TSH, FT3 and BMI were the influencing factors of abnormal lipid metabolism in MDD patients with abnormal glucose metabolism (all P < 0.05). MDD patients with abnormal glucose metabolism have a high prevalence of abnormal lipid metabolism. Moreover, abnormal glucose metabolism was an independent risk factor for abnormal lipid metabolism in patients with MDD. In addition, thyroid hormone function and BMI may contribute to the co-occurrence of abnormal lipid metabolism in MDD patients with abnormal glucose metabolism.
Plasticity in metabolism of maternal androgens in avian embryos
Authors: Wang Yuqi , Riedstra Bernd , de Vries Bonnie , van Faassen Martijn , Pranger Alle , Kema Ido , Groothuis Ton 
Published: May 2023

AbstractMothers can influence offspring phenotypes by transferring non-genetic information to the young, which provides them with a flexible tool to adjust the developmental trajectory of the young in fluctuating environments. Mothers can differentially deposit their resources in the same reproductive attempt in relation to the offspring position in the sibling hierarchy. However, whether embryos from different positions can be plastic in their response to the maternal signals, potentially leading to a mother–offspring conflict, is yet unclear. We used Rock pigeons (Columba livia), that lay two egg clutches where maternal androgen levels in second laid eggs at oviposition are higher than in first laid eggs, and investigated the plasticity of embryonic metabolism of maternal androgens. We experimentally elevated androstenedione and testosterone levels in first eggs to that present in second eggs and measured the change in androgen levels and its main metabolites (etiocholanolone and conjugated testosterone) after 3.5 days of incubation. We found that eggs with increased androgens show a different degree of androgen metabolism depending either on the egg laying sequence or initial androgen levels or both. Our findings indicate that embryos have certain plasticity in response to maternal androgen levels depending on maternal signals.
Nanoparticle-based targeting of microglia improves the neural regeneration enhancing effects of immunosuppression in the zebrafish retina
Authors: Emmerich Kevin , White David T. , Kambhampati Siva P. , Casado Grace L. , Fu Tian-Ming , Chunawala Zeeshaan , Sahoo Arpan , Nimmagadda Saumya , Krishnan Nimisha , Saxena Meera T. , Walker Steven L. , Betzig Eric , Kannan Rangaramanujam M. , Mumm Jeff S. 
Published: May 2023

AbstractRetinal Müller glia function as injury-induced stem-like cells in zebrafish but not mammals. However, insights gleaned from zebrafish have been applied to stimulate nascent regenerative responses in the mammalian retina. For instance, microglia/macrophages regulate Müller glia stem cell activity in the chick, zebrafish, and mouse. We previously showed that post-injury immunosuppression by the glucocorticoid dexamethasone accelerated retinal regeneration kinetics in zebrafish. Similarly, microglia ablation enhances regenerative outcomes in the mouse retina. Targeted immunomodulation of microglia reactivity may therefore enhance the regenerative potential of Müller glia for therapeutic purposes. Here, we investigated potential mechanisms by which post-injury dexamethasone accelerates retinal regeneration kinetics, and the effects of dendrimer-based targeting of dexamethasone to reactive microglia. Intravital time-lapse imaging revealed that post-injury dexamethasone inhibited microglia reactivity. The dendrimer-conjugated formulation: (1) decreased dexamethasone-associated systemic toxicity, (2) targeted dexamethasone to reactive microglia, and (3) improved the regeneration enhancing effects of immunosuppression by increasing stem/progenitor proliferation rates. Lastly, we show that the gene rnf2 is required for the enhanced regeneration effect of D-Dex. These data support the use of dendrimer-based targeting of reactive immune cells to reduce toxicity and enhance the regeneration promoting effects of immunosuppressants in the retina.
Revisiting blood pressure and body fluid status
Authors: Kitada Kento , Nishiyama Akira 
Published: May 2023

Abstract
Homeostasis of body fluid is a key component for maintaining health. An imbalance of body sodium and water causes various pathological states, such as dehydration, volume overload, hypertension, cardiovascular and renal diseases, and metabolic disorders. Conventional concepts regarding physiology and pathophysiology of body sodium and water balance have been established by several assumptions. These assumptions are that the kidneys are the master regulator of body sodium and water content, and that sodium moves inside the body in parallel with water. However, recent clinical and basic studies have proposed alternative concepts. These concepts are that body sodium and water balance are regulated by various organs and multiple factors, such as physical activity and the environment, and that sodium accumulates locally in tissues independently of the blood status and/or water. Various concerns remain unclear, and the regulatory mechanism of body sodium, fluid, and blood pressure needs to be readdressed. In the present review article, we discuss novel concepts regarding the regulation of body sodium, water, and blood pressure with a particular focus on the systemic water conservation system and fluid loss-triggered elevation in blood pressure.
The ACTIVATE Digital Health Pilot Program for Diabetes and Hypertension in an Underserved and Rural Community
Authors: Kim Katherine K. , McGrath Scott P. , Solorza Juan L. , Lindeman David 
Published: May 2023

Abstract
Background Community health centers and patients in rural and agricultural communities struggle to address diabetes and hypertension in the face of health disparities and technology barriers. The stark reality of these digital health disparities were highlighted during the coronavirus disease 2019 pandemic.
Objectives The objective of the ACTIVATE (Accountability, Coordination, and Telehealth in the Valley to Achieve Transformation and Equity) project was to codesign a platform for remote patient monitoring and program for chronic illness management that would address these disparities and offer a solution that fit the needs and context of the community.
Methods ACTIVATE was a digital health intervention implemented in three phases: community codesign, feasibility assessment, and a pilot phase. Pre- and postintervention outcomes included regularly collected hemoglobin A1c (A1c) for participants with diabetes and blood pressure for those with hypertension.
Results Participants were adult patients with uncontrolled diabetes and/or hypertension (n = 50). Most were White and Hispanic or Latino (84%) with Spanish as a primary language (69%), and the mean age was 55. There was substantial adoption and use of the technology: over 10,000 glucose and blood pressure measures were transmitted using connected remote monitoring devices over a 6-month period. Participants with diabetes achieved a mean reduction in A1c of 3.28 percentage points (standard deviation [SD]: 2.81) at 3 months and 4.19 percentage points (SD: 2.69) at 6 months. The vast majority of patients achieved an A1c in the target range for control (7.0–8.0%). Participants with hypertension achieved reductions in systolic blood pressure of 14.81 mm Hg (SD: 21.40) at 3 months and 13.55 mm Hg (SD: 23.31) at 6 months, with smaller reductions in diastolic blood pressure. The majority of participants also reached target blood pressure (less than 130/80).
Conclusion The ACTIVATE pilot demonstrated that a codesigned solution for remote patient monitoring and chronic illness management delivered by community health centers can overcome digital divide barriers and show positive health outcomes for rural and agricultural residents.
Evaluación de tratamiento con mini-open para pinzamiento femoroacetabular tipo CAM
Authors: Salgado Martín , Avilés Carolina , Fernández Felipe , Letelier María Loreto 
Published: May 2023

Resumen
Objetivo Describir y evaluar los resultados del tratamiento del pinzamiento femoroacetabular (PFA) con mini-open no asistido en una población definida.
Materiales y Métodos Se realiza una descripción prospectiva de cincuenta pacientes jóvenes con diagnóstico de PFA tipo CAM, con baja demanda deportiva, tratados con mini-open no asistido. Se incluyeron pacientes mayores de 18 años con PFA sintomático, con estudio radiológico completo y con test de lidocaína positivo. Se excluyeron pacientes con patología previa o subyacente de cadera comprometida. Se comparó la Escala de Cadera Harris modificada (Modified Harris Hip Score, MHHS, en inglés) en los periodos pre y posoperatorio (por el test de Wilcoxon) y los puntajes pre y posoperatorio en la escala visual análoga (EVA) (por el test análisis de la varianza [analysis of variance, ANOVA, en inglés] de Friedman). Se consideró significativo un valor de p < 0,05. En total, 50 pacientes cumplían los criterios de inclusión: 33 hombres y 17 mujeres.
Resultados La edad promedio fue de 36,8 ±  6,5 años. El ángulo alfa promedio fue de 62,6° ±  5,6°. Todos presentaron artrosis de grado 1 de Tonnis. Un total de 39 pacientes tenían nivel de actividad 3 (en la escala de Tegner). El seguimiento promedio fue de 27,3 ±  6,2 (mínimo de 12) meses. El MHHS mejoró desde una mediana preoperatoria de 60,5 (rango: 30,8–84,7) puntos a una mediana posoperatoria de 96,8 (rango: 91,3–100) puntos (p < 0,001). Todos los pacientes presentaron disminución significativa del dolor, con mediana de 0 en la EVA al año de seguimiento.
Conclusión Esta técnica presenta buenos resultados clínicos y funcionales en pacientes de baja demanda deportiva. Faltan estudios que demuestren sus ventajas respecto de la resección de bump de mayor tamaño o en otras localizaciones.Nivel de Evidencia: 4.
Avulsión proximal de los isquiotibiales, del diagnóstico al tratamiento: una revisión del tema en relación con un caso clínico
Authors: Carrasco Miguel , Edwards Diego , Carrasco Consuelo , Zelaya Gerardo , Schmidt-Hebbel Andrés , Bianchi Sebastián 
Published: May 2023

ResumenLa avulsión proximal de los isquiotibiales (ITs) es una lesión poco frecuente, la que puede producir alteraciones funcionales permanentes, además de tener un riesgo de rerrotura elevado (en hasta un 30% de los casos).Ocurre habitualmente en deportistas que realizan aceleraciones rápidas o requieren “movimiento balístico” durante su entrenamiento, aunque también se presentan en la población más sedentaria con caídas a nivel en mecanismos de baja energía. El mecanismo más frecuente de lesión es una contracción excéntrica de los ITs al intentar resistir una caída, con la cadera en flexión y la rodilla en extensión.Existen numerosos signos descritos al examen físico y dentro del estudio, si bien la radiografía convencional y la ecografía son de gran utilidad, se reconoce a la resonancia magnética como el estándar de oro para su correcto diagnóstico.El tratamiento dependerá del tipo de paciente y sus expectativas, aunque en los últimos años se ha considerado cada vez con más relevancia la opción quirúrgica en los casos en los que se presenta una avulsión completa de los ITs asociada a una retracción de estos.Se presenta una revisión del tema en relación con un caso clínico resuelto de forma quirúrgica, y se discuten las generalidades, la presentación clínica, el estudio y las opciones de tratamiento con las que se cuenta en la actualidad.
Antithrombin Deficiency Is Associated with Prothrombotic Plasma Fibrin Clot Phenotype
Authors: Natorska Joanna , Corral Javier , de la Morena-Barrio Maria Eugenia , Bravo-Pérez Carlos , Bagoly Zsuzsa , Bereczky Zsuzsanna , Treliński Jacek , Witkowski Michał , Klajmon Adrianna , Undas Anetta , Ząbczyk Michał 
Published: May 2023

Background Deficiency of antithrombin increases risk of venous thromboembolism. We hypothesized that antithrombin deficiency affects fibrin clot structure and function.
Methods We evaluated 148 patients (age: 38 [32–50] years; 70% women) with genetically confirmed antithrombin deficiency and 50 healthy controls. Fibrin clot permeability (Ks) and clot lysis time (CLT) along with thrombin generation capacity were assessed before and after antithrombin activity normalization in vitro.
Results Antithrombin-deficient patients had lower antithrombin activity (−39%) and antigen levels (−23%) compared with controls (both p < 0.01). Prothrombin fragment 1 + 2 levels were 26.5% higher in patients with antithrombin deficiency than in controls along with 94% increased endogenous thrombin potential (ETP) and 108% higher peak thrombin (all p < 0.01). Antithrombin deficiency was associated with 18% reduced Ks and 35% prolonged CLT (both p < 0.001). Patients with type I (n = 65; 43.9%) compared with type II antithrombin deficiency (n = 83; 56.1%) had 22.5% lower antithrombin activity (p < 0.001) and despite similar fibrinogen levels, 8.4% reduced Ks, 18% prolonged CLT, and 30% higher ETP (all p < 0.01). Reduced Ks was associated with lower antithrombin antigen level (β = − 6.1, 95% confidence interval [CI]: −1.7 to −10.5), while prolonged CLT was associated with lower antithrombin antigen (β = − 69.6, 95% CI: −9.6 to −129.7), activity (β = − 2.4, 95% CI: −0.3 to −4.5), higher PAI-1 (β = 12.1, 95% CI: 7.7–16.5), and thrombin-activatable fibrinolysis inhibitor levels (β = 3.8, 95% CI: 1.9–5.7). Addition of exogenous antithrombin reduced ETP (−42%) and peak thrombin (−21%), and improved Ks (+8%) and CLT (−12%; all p < 0.01).
Conclusion Our study suggests that enhanced thrombin generation and prothrombotic plasma fibrin clot phenotype can contribute to increased risk of thrombosis in patients with antithrombin deficiency.