bluuebunny/crossref_metadata_2025_split huggingface dataset:
Study on in-plane/out-of-plane seismic performance of opening infill wall-RC frame structure with a new type of flexible connection
Authors: Zhang Maohua , Zhang Maohua , Junnan DING , Wei Jin , Kang Ding 
Published: February 2023

Abstract
When an earthquake occurs, the seriously damaged infill walls have an adverse impact on frame due to infill-frame interaction. Some codes suggest that the infill walls should be isolated from frames or use a flexible connection construction, but these applications may reduce OOP (out-of-plane) stability and increase the risk of OOP collapse. In this study, a new type of flexible connection is adopted for the opening infill wall-RC frame structures. The infill wall-RC frame structures with rigid connection, traditionally flexible connection and new type of flexible connection in this context were examined experimentally and numerically, and their IP and OOP after IP (in-plane) damage seismic performance were compared. As a result of the study, the new type of flexible connection effectively reduces IP damage of the infill walls and undesirable infill-frame interaction. Compared with rigid and traditional connection, the frame with new flexible connection improves the energy dissipation capacity by about 37.8% and 3.5%, respectively. At the same time, the OOP strength and stiffness of the new flexible connection increased by 119.8% and 104.2% in the same prior IP drift ratio than that of traditional flexible connection. It is thought that the steel cable structure can improve the restraint of frames on infill walls, which is beneficial to development of OOP horizontal arch mechanism.
Intensive Care Management and Outcome of Women with Hypertensive Diseases of Pregnancy at a tertiary Care Hospital in Mogadishu, Somalia.
Authors: Hilowle Nasra Mohamud , Ahmed Said Abdirahman , Ali Khadija Yusuf , Ali Abdijalil Abdullahi , Waberi Mohamud Mire , Hassan Mohamed Sheikh , Hassan Mohamed Omar 
Published: February 2023

Abstract
Hypertensive diseases of pregnancy remains severe disease burden in developing countries and is associated with increased morbidity and mortality for both mother and the baby. This study highlights the level of morbidity and mortality associated with hypertensive pregnant mothers admitted to intensive care unit. Methods: - This retrospective study was conducted in Mogadishu Somali Turkish Training and Research Hospital from February 2019 to July 2022. The study focused on the different complications, managements and final outcomes of hypertensive pregnant mothers admitted to the Intensive care unit. Results: The mean age of studied patients was 25 ± 8years. Considering the comorbidities, 38 out of 71 patients had comorbid conditions, including a previous history of gestational hypertension 26(36.6%), a history of previous pre-eclampsia 8 (11.2%) and history of diabetics 4(5.6%). The most common reason for being taken to the intensive care unit (ICU) was having a seizure (n = 33, 46.5%), followed by having very high blood pressure (n = 20, 28.2%), and being confused (n = 18, 25.3%). Regarding the clinical characteristics of these patients, those in their 3rd trimester were the most common among them. The majority of patients, on the other hand, were primigravida (n = 53, 74.6%), and nulliparous (n = 50, 70%). Infection was the most common maternal complication during ICU admission (66.7%), followed by cardiac-related arrhythmia (66.7%), bleeding (48%), acute renal failure (18.4%), HEELP syndrome (16.4%), severe anemia (9.6%), and stroke (8.7%). Despite the fact that less than 10% of patients had severe anemia necessitating transfusion during admission, 51 (71.8%) received a transfusion for other reasons, such as severe bleeding or dialysis. 10 (14.1%) needed hemodialysis due to acute renal failure. On the other hand, 65 (91.5%) needed mechanical ventilation. For the delivery, 70 (99%) had a cesarean section, while 1 (1%) had a vaginal delivery. Out of those who had a cesarean section, 75.7% had it under general anesthesia, while the remainder (24.3%) had it under spinal anesthesia. Unfortunately, 11.1% of these patients died, and 88.9% were discharged. There were associations between mortality and some complications, especially acute renal failure (p-value less than 0.02) and infection (p-value less than 0.003). Conclusion: A hypertensive women hospitalized to an intensive care unit (ICU) have high morbidity and mortality rates. For a subsequent sizable multi-central investigation, these data serve as the foundational research.
Path Integral for Graphene quasiparticles in the presence of two plane wave fields
Authors: Moures Nadjiba , Boudjedaa Tahar , Benzair Hadjira 
Published: February 2023

Abstract
In this present paper, we calculate the Green function for graphene quasiparticles which is described by the massless Dirac equation in interaction with one plane wave field and with two plane wave fields in particular configuration according to the supersymmetric path integral formulation. The calculation are simplified by using two identities one bosonic and the other fermionic. Analytic expressions for these Green functions are given and the wave functions are presented for the two considered cases.
P A C S: 03.65.Ca, 03.65.Ge, 03.65.Pm.
Correlates of cost-related medication rationing and non-adherence among cancer survivors in the US
Authors: Chido-Amajuoyi Onyema G. , Osaghae Ikponmwosa , Agogbuo Ogechi , Undavalli Chaitanya , Onyeaka Henry , Ghoweba Mohamed , Egbe Tiffany , Koya Rama , Frase Larry , Akinboro Oladimeji 
Published: February 2023

Abstract
Purpose: This study aims to describe the characteristics of cancer survivors who are at heightened risk of adopting cost-saving behaviors as a means to cope with financial hardship.
Methods: Study data were derived from the 2018 National Health Interview Survey. Weighted multivariable logistic regressions were used to assess the relationship between cost-related medication rationing and non-adherence and the sociodemographic and behavioral characteristics of US cancer survivors.
Results: A total of 2594 cancer survivors were respondents. As income increased, the odds of medication rationing and non-adherence decreased. Cancer survivors aged 65 years and older were less likely to skip or take less medication to save costs than those aged < 45 years. Compared to respondents with health insurance coverage, those without health insurance coverage were over two folds (aOR: 2.38, 95% CI: 1.07-5.29) more likely to skip medications (aOR: 2.38, 95% CI: 1.07-5.29) and take less medication (aOR: 3.53, 95% CI: 1.62-7.72) to save cost. Current smokers were more likely to skip medications (aOR: 1.98, 95% CI: 1.13-3.48) or take less medication (aOR: 1.99, 95% CI: 1.16-3.42) to save money compared to never-smokers.
Conclusions: Cancer survivors who skip or ration medications are more likely to be younger, low-income, current smokers, with no health insurance coverage. Results call for multi-pronged interventions targeting at-risk groups identified in this study.
Implications for Cancer Survivors: Smoking cessation, expanding insurance coverage for cancer survivors, and furthering ongoing governmental-level efforts aimed at reducing drug prices can help tackle financial hardship and improve outcomes for cancer survivors
Patient’s and healthcare provider’s experiences with Opioid Maintenance Treatment (OMT): A qualitative evidence synthesis
Authors: Steiro Asbjorn , Hestevik Christine Hillestad , Muller Ashley (Ley) 
Published: February 2023

Abstract
Background
Opioid Maintenance Treatment (OMT) is the gold standard for people with opioid dependence but drop-out can be high. Understanding both patients and health personnel’s experiences with the treatment can provide valuable information to improve the quality of OMT and to increase acceptability and accessibility of services. The aim of this systematic review is to explore the knowledge base of experiences of patients and health care providers, in order to inform the Norwegian Directorate of Health’s national guideline process.
Methods
We conducted a qualitative evidence synthesis. We first conducted a systematic literature search in electronic databases. Among the 56 studies that met inclusion criteria, we extracted data about study contexts and populations to assess relevance to our research question and on data richness, then purposively sampled to arrive at a manageable sample. Two researchers independently extracted and coded data in Nvivo, and we used the Andersen’s healthcare utilization model to organize and develop codes into four main domains. We assessed the methodological quality of the included studies, and our confidence in findings using CERQual.
Results
After a literature search retrieved 56 references, we included and analyzed 24 qualitative studies of patients’ and health providers’ experiences with OMT services. We found that stigma was a cross-cutting theme that linked the four domains of Andersen’s healthcare utilization model. Stigma from people outside OMT was a barrier to seeking out and remaining in treatment. Both patients and health personnel perceived that the OMT system contributed to further stigma. OMT services itself was a source of stigma and communication and staff-patient relations were either facilitators or barriers to treatment compliance. Inadequate knowledge and competence among health care providers was a barrier as reported by both patients and providers, which affected the availability and quality of OMT. Patients also had expectations related to non-medical treatment outcomes of OMT such as employment, housing and social relationships. Patients continuously balanced positive expectations of OMT, and negative outcomes related to stigma.
Conclusion
These results show the need for increased competence in relational work, among OMT personnel, to improve the quality and to avoid stigma and negative attitudes among health providers. OMT should also have a holistic approach to meet patients' non-health-related needs, as these seem to be crucial for treatment compliance and outcomes.
Seasonal Fluctuation in the Floristic Diversity of Prashar Alpine Pasture, District Mandi, Himachal Pradesh
Authors: KUMAR AKSHAY 
Published: February 2023

Abstract
Seasonal fluctuation in the plant diversity provide basis for devising suitable strategies for management and conservation of the plant resources. Accordingly, a study was conducted to understand the plant diversity of Prashar alpine pasture, District Mandi, Himachal Pradesh during the year 2017 between 2550–2750 m elevation ranges. The study was carried out on seasonal basis. The study was carried out in summer season in May, rainy season in August and winter season in November. A total of 44 plant species belonging to 24 families and 35 genera were recorded in summer season, a total of 72 plant species belonging to 28 families and 58 genera were recorded in rainy season and a total of 13 plant species belonging to 6 families and 10 genera were recorded in winter season from the study area. Dominant families were Asteraceae, Lamiaceae, Rosaceae, Poaceae and Polygonaceae. A total of 56 medicinal plant species recorded from the pasture, out of which two species viz; Roscoea alpina and Selinum vaginatum fall in the category of threatened plants.
Design and synthesis of Diphenyl-1H-imidazole analogs towards SARS CoV-2 3CLpro inhibition for the treatment of COVID-19
Authors: Kanhed Ashish M. , Vora Amisha , Thakkar Ami , Rudramurthy Gudepalya Renukaiah , Shandil Radha Krishan , Yogi Maddipatla , Harisha Rajappa , Singh Mayas , Narayanan Shridhar 
Published: February 2023

Abstract
COVID-19 caused by novel corona virus (SARS-CoV-2) is the major pandemic of the decade claiming millions of lives causing severe disruptions to society. Despite rapid development of COVID-19 vaccines, condition is still not under control and newer antiviral drugs are required. In the present work, we describe the design and synthesis of Diphenyl-1H-imidazole derivatives as a potential lead series for SARS-CoV-2 3CLpro enzyme inhibition. The synthesized molecules were screened for SARS-CoV-2 3CLpro enzyme inhibition at 20µM concentration. All the synthesized compounds (6-14) showed inhibition in the range of 88 to 99%. They were further tested for anti-SARS-CoV-2 activity against ancestral Wuhan and the Delta variants in virus infected cells. The compounds 4-(4-hlorophenyl)-2-(3,4-dimethoxyphenyl)-1H-imidazole (9), 4-(2,4-dichlorophenyl)-2-(3,4-dimethoxyphenyl)-1H-imidazole (10), 4-(4-(2,4-dichlorophenyl)-1H-imidazol-2-yl)benzene-1,2-diol (14) showed promising activity against both Wuhan (IC50: 7.7 µM, 12.6 µM and 11.8 µM, respectively) and Delta (IC50: 7.4 µM, 13.8 µM and 12.1 µM, respectively) variant of COVID-19. Our results demonstrate efficacy of diphenyl-1H-imidazole derivatives as promising ligands for further development and optimization against COVID-19.
The tourist patterns in European countries. Application of a protocol for dynamic clustering of geographic spaces
Authors: Landaluce-Calvo M Isabel 
Published: February 2023

Abstract
The methodological proposal presented in this paper enables a comprehensive multivariate exploratory analysis of time series taken in different geographical contexts. More specifically, it is a four-stage protocol for the identification of different dynamic patterns and the subsequent formation of geographic clusters. The clustering strategy compares the shapes of the trajectories using a natural, unsupervised approach based on learning from data. The exploratory techniques used in this method, which are readily applicable in any area of study, begin by reducing the dimensionality of a three-way data array. The potential of the strategy design is illustrated through a study of tourism dynamics in 27 European countries over the period 2007-2019. The profiles found for the trend and seasonal components reveal five distinct tourism patterns with some singularities. The choice of this sector for empirical research is not accidental. Tourism is connected to areas related to both economic and social activity. That is why their correct measurement and analysis are so interesting and necessary.
Identification of hsa-miR-4770 as characteristic microRNA of gallbladder carcinoma and exploration on the ceRNA regulation mechanism via integrated bioinformatics analysis
Authors: Shao Hanrui , Zhu Jiahai , Zhu Ya , Liu Lixin , Zhao Songling , Kang Qiang , Liu Yunxia , Zou Hao 
Published: February 2023

Abstract
Background and Aims:
Gallbladder carcinoma (GBC) is a highly malignant tumor with a poor overall prognosis. This study aimed to identify the characteristic microRNAs (miRNAs) of GBC and the competing endogenous RNA (ceRNA) regulatory mechanisms.
Methods
GBC-related differentially expressed miRNAs (DE-miRNAs) were authenticated by differential expression analysis and weighted gene co-expression network analysis (WGCNA). The characteristic miRNA was extracted by least absolute shrinkage and selection operator (LASSO) and Support vector machine-recursive feature elimination (SVM-RFE). Targeting genes (mRNAs), upstream circularRNAs (circRNAs), and long noncoding RNAs (lncRNAs) prediction for the characteristic miRNAs was conducted by using the Starbase database. The lncRNA(circRNA)-miRNA-mRNA network was created by Cytoscape software. Gene Ontology (GO) and KEGG enrichment analysis was implemented by clusterProfiler R package. The varElect was applied to analyse the target genes, and search for functions and interactions by GeneMANIA. The expression of characteristic miRNA in clinical samples was verified by quantitative real-time polymerase chain reaction (RT-qPCR).
Results
A total of 131 GBC-related DE-miRNAs were obtained. The hsa-miR-4770 was defined as characteristic miRNA for GBC. The ceRNA network containing 211 mRNAs, 1 miRNA, 2 lncRNAs, and 48 circRNAs was created. The downstream genes were mainly involved in actin filament organization, cell-substrate adhesion, cell-matrix adhesion, reactive oxygen species metabolic process, glutamine metabolic process and extracellular matrix (ECM)-receptor interaction pathway. 10 key genes in the network, namely BRCA1, CHEK2, RB1, CASP8, PTGS2, CD44, KRT19, CDK1, PVT1, and MXRA5 were found to be most correlated with disease. Multiple genes involved in cell cycle-related processes, p53 related pathway, and extrinsic apoptotic signaling pathway. RT-qPCR result demonstrated that the expression trends of hsa-miR-4770 was consistent with the public database.
Conclusion
We identified hsa-miR-4770 as the characteristic miRNA for GBC. The ceRNA network of hsa-miR-4770 may play key roles in GBC. This study provided a little basis for potential pathogenesis of GBC.
Apatinib with first-generation EGFR-TKIs as second-line treatment for patients with advanced non-small cell lung cancer with acquired resistance: a retrospective case series analysis
Authors: Yimin Wu , Zhouyu Zhu , Jie Min , Chai Ying 
Published: February 2023

Abstract
Background: Resistance to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) develops in most patients with non-small cell lung cancer (NSCLC) and negates the effects of the drug. Herein we try to explore a feasible method for patients with acquired resistance to first-generation EGFR-TKIs.
Methods: This study primary assessed the efficacy of first-generation EGFR-TKIs combined with low-dose apatinib (a vascular endothelial growth factorreceptor-2 (VEGFR-2) TKI) in NSCLC patients with acquired resistance to EGFR-TKIs. We retrospect the clinical date of 50 NSCLC patientssuffering from gradual disease progression following efficacious targeted therapy using first-generation EGFR-TKIs. Patients received apatinib(250 mg, p.o.) once-daily with a first-generation EGFR-TKI (gefitinib or icotinib) until disease progression or unacceptable toxicity.The primary outcome measures the proportion of patients with a disease control assessed by the investigators according to RECIST 1.1.
Results: The median duration of observation was 7.5 (range, 1–20) months. The disease control rate was 90.0%, overall response rate was 32.0%. Hypertension, hand-foot syndrome, proteinuria and rash were the most common adverse events. Significant adverse events included hypertension and hemorrhage, only 2 patient quit the treatment because of adverse events. When disease progressed again after experiencing effective combined targeted therapy, patients could receive efficacious treatment with osimertinib or chemotherapy.
Conclusions: Our findings suggest that adding extra apatinib to first-generation EGFR-TKIs may prolong the effective duration of efficacy of first-generation EGFR-TKI. Besides, convenience and potential therapeutic safety advantages is also the advantages of our regimen.
Analyses under the curve, identifying how invisible gold is held in pyrite
Authors: Gregory Daniel D. 
Published: February 2023

AbstractWhen laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS) analyses of pyrite plot below the gold solubility line on a gold vs. arsenic plot and have relatively flat counts on laser ablation time-resolved output graphs, it is often interpreted that the gold is held within the pyrite structure. The study by Ehrig et al. (2023, this issue) shows, using a combination of LA-ICP-MS spot analyses of gold in pyrite, transmission electron microscopy, and electron backscatter diffraction that this is not necessarily the case. Furthermore, they use these same techniques to identify how trace elements, including gold, are remobilized in pyrite during deformation and metamorphism.
Implementation of Character Education in Religious Culture: Multi-case study in Public and Islamic Junior High Schools
Authors: Noor Azizah Yunita 
Published: February 2023

In an effort to internalize religious values in children’s character, a religious culture is needed in the school. This is because the portion of time given to Islamic subjects in schools is only relatively less on a weekly level, so the opportunities for teachers to provide guidance and direction are also relatively small. In addition, the religious values that exist in children are often defeated by the negative cultures around it. Therefore, character education in religious culture is considered to be able to shape the character of the students. This research aims to describe: (1) Character education planning on religious culture at State Junior High School 4 & Madina Islamic Junior High School (2) Implementation of character education on religious culture in State Junior High School 4 & Madina Islamic Junior High School. This research uses a qualitative approach using a multi-case study design. Data collection is conducted using in-depth interviews, observations & documentation. Research informants are principals of school, Islamic education teachers. The data obtained by the informant & the subjects studied were interpreted and analyzed using cross-case data analysis. The findings of the study proved that: (1) Character education planning on religious culture at State and Islamic Junior High School is carried out using the standard set of character of students, forming religious culture, and providing supporting facilities, setting the standard competencies of graduates, and dividing the responsibility of mentor for each student. (2) The implementation of character education in religious culture in State Junior High School 4 is carried out using integrating the standard characters contained into the daily, weekly, monthly religious culture. And the application of character education in religious culture at Madina Islamic Junior High School is done using integrating the raw characters contained into the religious culture.
Urban Green Spaces in Brazil: challenges and opportunities in the context of the COVID-19 pandemic
Authors: Da Silva Romero Gomes Pereira , Lima Cláudia Lins , Quinn Sterling D. , Afelt Aneta , Laques Anne-Elisabeth , Saito Carlos Hiroo 
Published: February 2023

During the COVID-19 pandemic, urban green spaces were considered less prone to contagion, and thus people adopted them as alternative sites for improving mental health. The One Health concept advocated by health organizations worldwide supports the idea that the well-being of urban residents is strongly linked with physical activity in green areas. As the world grapples with the physical and mental health consequences of the COVID-19 pandemic, it becomes clearer that access to urban green spaces is a human rights issue. This study compared previously-mapped urban green spaces in five metropolitan regions in Brazil with the results of an extensive survey of municipal managers concerning possible increase in demand of population for green spaces. Urban green spaces of over 625 m2 were mapped in 117 municipalities, the total area of 4170 km2 representing 37.4% of the urban spaces analyzed in the five metropolitan regions. Out of these 117 municipalities, 49 had data available concerning demands of green spaces in the pandemic context. Overall, 20 municipalities (representing all five metropolitan regions) stated that there was an increase in visitation in urban green spaces, and 13 more indirectly suggested possible demands. When sustainability transitions are understood as geographical processes that happen in concrete places, urban green spaces then represent real locations where sustainable transitions can begin. The unequal distribution of these spaces also brings into consideration a social justice perspective, as well as aspects of public health that involve climate change resilience and epidemiological risk (SDG 11).