bluuebunny/crossref_metadata_2025_split huggingface dataset:
ANTI-DYSLIPIDAEMIA AND CARDIO-PROTECTIVE EFFECTS OF NIGERIAN BITTER HONEY IN STREPTOZOTOCIN INDUCED DIABETIC RATS
Authors: ADEOYE Olufunso B. , IYANDA Abolape A. , DANIYAN Michael O. , ADEOYE David A. , OLAJIDE Omoyiola L. , AKINNAWO Omowumi O. , ADETUNJI Adebola O. , OSUNDINA Babatunde O. , OLATINWO Olajoju M. 
Published: May 2023

Background and Aim: Chronic hyperglycemia, oxidative stress, and dyslipidemia usually predispose to cardiac aberrations. Certain honey samples have been reported to worsen glycemic control or proven to be cardiotoxic. The study sought to elucidate the roles of Nigerian bitter honey in experimental diabetes.
Experimental Procedures: Diabetes was induced in adult female Wistar rats (90–110g) by single administration of streptozotocin (65 mg/kg body weight, i.p.). Rats were randomly allocated into six groups (n= 8). Bitter honey (50 mg/kg) and metformin (100 mg/kg) were orally administered daily for 28 days. Animals were sacrificed on day 29 and blood samples were obtained via cardiac puncture. Lipid profile and lipid peroxidation analysis were carried out using standard methods. Atherogenic, coronary, and cardiovascular risk indexes were calculated. Heart, pancreas, and lung tissues were harvested and subjected to histopathological assessment. Data were analyzed using one way ANOVA, and statistical significant level was set at p<0.05.
Result and Discussion: Bitter honey treatment in the diabetic animals significantly reduced hyperglycemia, triglyceride, total cholesterol, low-density lipoprotein, malondialdehyde, and cardiovascular risk levels (p<0.05). Correspondingly, HDL and reduced glutathione levels were significantly higher (p<0.05). Bitter honey preserved the histoarchitectural integrity of the cardiomyocytes and lungs tissue.
Conclusion: The bitter honey is a highly remarkable repository of naturally occurring bioactive compounds that can potentially modulate downstream biochemical pathways of hyperglycemia, dyslipidemia and lipid peroxidation. The bitter honey may therefore be a promising new source of anti-diabetic and cardio protective nutraceuticals.

Peer Review History:
Received: 9 February 2023; Revised: 7 March; Accepted: 29 April 2023, Available online: 15 May 2023
Academic Editor: Dr. Amany Mohamed Alboghdadly, Ibn Sina National College for Medical Studies in Jeddah, Saudi Arabia, amanyalboghdadly@gmail.com
Received file: Reviewer's Comments:
Average Peer review marks at initial stage: 6.0/10
Average Peer review marks at publication stage: 7.0/10
Reviewers:
Dr. Sangeetha Arullappan, Universiti Tunku Abdul Rahman, Malaysia, sangeetha@utar.edu.my
Dr. Rawaa Souhil Al-Kayali, Aleppo University, Syria, rawah67@hotmail.com
EFFECT OF CATHA EDULIS (KHAT) EXTRACT ON COLOR STABILITY OF ACRYLIC RESIN DENTURE TEETH: AN IN-VITRO STUDY
Authors: Mohammed Badea Saeed Abdu , Al-Kebsi Abbas M , AL-Haddad Khaled A , Al-Sanabani Nesreen F. , Al-Najhi Mohammed Mohammed Ali , Al-hamzi Amani Hussein Y , Al-Shamahy Hassan Abdulwahab , Al-Harf Fatima Ahmed , Alalwani Nadhra Nassar 
Published: May 2023

Background and aim: Long-term denture tooth color stability for patients is an important criterion in choosing the types of dental materials to use as one of the main concerns in treatment. Discoloration of denture teeth may result in patient dissatisfaction and an additional expense for their replacement. In Yemen, khat (Catha Edulis) chewing habit may affect the color of acrylic denture teeth. The aim of this study was to assess the effect of khat extract on color stability of reinforced acrylic resin denture teeth.
Materials and Methods: Experimental design carried to 3 brands of reinforced acrylic resin teeth from three manufacturers, Vitapan, FX-Anterior and Shanghai-SND were evaluated 40 specimens (maxillary central incisors) of each brand were selected systematically and grouped into A, B and C respectively. All samples were stored in distilled water (DW) at 37 °C for 24 hours after which baseline colorimetric measurements were recorded by colorimeter. All the specimens were immersed for 24 hours daily and kept in an incubator at 37°C for 30 days. The KH was changed every 24 hours. Colorimeter was used for color change testing of each specimen after 10, 20 and 30 days on CIE L* a* b*. Then the collected data was analyzed using SPSS version 23.
Results: The results of this study shows that there was a significant effect of KH on acrylic teeth (p<0.001). Also, a significant interaction between the three brands acrylic teeth and KH was found (p<0.05). The effect of time on acrylic teeth color stability was statistically significant (p<0.05). The brands teeth specimens at 10, 20 and 30 days in KH revealed more significantly color change than DW (p<0.05).
Conclusions: The khat homogenate (KH) causes discoloration on the 3 brands of reinforced acrylic teeth and the discoloration increases with the passage of time. The change of discoloration is acceptable clinically except in SND teeth. Vitapin teeth has more color stable compared to FX teeth and SND teeth.

Peer Review History:
Received: 12 February 2023; Revised: 13 March; Accepted: 25 April 2023, Available online: 15 May 2023
Academic Editor: Prof. Dr. Gorkem Dulger, Duzce University, Turkey, gorkemdulger@yandex.com
Received file: Reviewer's Comments:
Average Peer review marks at initial stage: 6.0/10
Average Peer review marks at publication stage: 7.0/10
Reviewers:
Dr. Khaled A AL-Haddad,Orthodontics, Pedodontics and Prevention Department Faculty of Dentistry, Sana'a University, Yemen, ya_haddadi@yahoo.com
Dr. Masoomeh S Ghahfarokhi, University of Benin, Nigeria, mshamsgh@yahoo.com
OROMANDIBULAR DYSTONIA: PREVALENCE, CLINICAL AND DEMOGRAPHIC DATA, THERAPEUTIC STRATEGIES OUT-COME FOR HUNDRED PATIENTS IN SANA’A CITY, YEMEN
Authors: Aldeen Haifa Mohammed Abdulmaged Sharaf , Abbas Al-Kasem Mohammed A , Al-Kibsi Taghreed Ahmed M , Al-Shamahy Hassan Abdulwahab , Jahaf Sara Hussien Ahmed , AL-Kaff Reem Hussein Sheikh Omar 
Published: May 2023

Background and aims: Dystonia is a movement disease characterized by persistent, uncontrollable muscle contractions that often lead to abnormal postures. The tongue, jaw, and mouth are all affected by OMD, which is an uncommon focal dystonia. OMD is a rare public health problem that takes time to diagnose and treat because it is frequently identified as psychogenic. This study sought to ascertain the frequency, demographics, clinical features, and treatment outcomes of patients with mandibular dystonia (OMD) in Sana'a, Yemen.
Methods: A prospective cross-sectional study was conducted; the study included 100 Yemeni adults attending the Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Sana'a University Clinics and Departments of Oral, Maxillofacial and Neurosurgery at Kuwait University Hospital and some private centers for maxillofacial medicine and neurosurgery in the city of Sana’a during the year 2022. The selected patients were complaining of contraction or involuntary movement of the masticatory, lingual and/or lower facial muscles. Age, gender, age at onset of illness, duration of illness, personal habits, type of OMD, previous and current treatments, and their outcomes were recorded on a standard, pre-designed questionnaire.
Results: The incidence rate of OMD is 19/100,000/year. Most of the patients (92%) are male while only 8% are female. The first episode onset is after stress (29%), 11% after illness, 6% after dental treatment, and 48% without causes. Jaw deviation dystonia was dominant at 65%, followed by jaw closing dystonia (42%), jaw protrusion dystonia (29%), and jaw opening dystonia (27%). After current treatment out-come, there was improvement on ability to eat ( from 12% to 24%, p=0.02), to speak (from 25% to 43%, p=0.007), the rate of no pain raised from 46% to 57%, the rate of no discomfort raised from 21% to 34% (p=0.04) and the score ≤ 5 of OMD raised from 47% to 72% (p=0.0003).
Conclusion: The incidence of OMD in Sana’a city is remarkably high, predominantly male, and peaks at 30, 40, and 50 years of age. Jaw deviation dystonia was the dominant type followed by jaw closing dystonia. After the current treatment outcome, the ability to eat has improved, the rate of pain and discomfort has decreased.

Peer Review History:
Received: 25 February 2023; Revised: 17 March; Accepted: 28 April 2023, Available online: 15 May 2023
Academic Editor: Dr. Sally A. El-Zahaby, Pharos University in Alexandria, Egypt, sally.elzahaby@yahoo.com
Received file: Reviewer's Comments:
Average Peer review marks at initial stage: 5.5/10
Average Peer review marks at publication stage: 7.0/10
Reviewers:
Dr. Bilge Ahsen KARA, Ankara Gazi Mustafa Kemal Hospital, Turkey, ahsndkyc@gmail.com
Dr. Ogbonna B. Onyebuchi, Nnamdi Azikiwe University, Awka, Nigeria, summitpharm@yahoo.com
POINT PREVALENCE OF COLORECTAL CANCER IN A MEGA CITY OF PAKISTAN, KARACHI – A CROSS SECTIONAL STUDY
Authors: Khaliq Sheikh Abdul , Fatima Anab , Siddiqui M. Ghias Uddin , Sheikh Mahmood , Un-Nisa Ayeshah Zaib- 
Published: May 2023

Background and Objective: Globally, Colorectal Cancers are also third most common cancers and fourth leading cause of death due to carcinoma. Burden of Colorectal Cancers is also high in Pakistan. The main risk factor for Colorectal Cancer is age, however, other risk factors are e.g. family history, irritable bowel disease, sedentary life-style, high visceral adipose tissues, smoking and alcohol. Hence; the main objective of current study was to determine point prevalence of Colorectal Cancers in a mega city of Pakistan, Karachi; a representative population of Pakistan. It is hypothesized that incidences of Colorectal Cancers would be higher in Karachi than rest of the country.
Materials and Methods: The retrospective cross-sectional study was conducted in Karachi. Duration of study was from January-2015 to October-2019. Data has been collected from two state-owned and four private hospitals of Karachi. Precision analysis technique was used to determine the sample size of study. Study is approved by Board of Advanced Studies & Research, University of Karachi (Reference Number: BASR/01046/Pharm.). Objective of study was explained to patients before initiation the study; informed consent was taken from each patient. S.P.S.S (Statistical-Package-for-Social-Sciences) software version 22 was used to analyze the data.
Results: Among 1,617 patients: male 54.35% (N=879); female 45.64% (N=738). Mean age of diagnosis of colorectal cancer: male 49.51±14.72 years; female 45.28±13.52 years. Significantly higher point prevalence was found in ethnicity speaking Sindhi compared with ethnicity speaking Balochi (p=0.001), Pashto (p=0.0001), Punjabi (p=0.001) and Siraiki (p=0.0001); Urdu speaking compared with Balochi speaking (p=0.0001), Pashto speaking (p=0.0001), Punjabi speaking (p=0.0001) and Siraiki speaking (p=0.0001) in male. In female; Sindhi speaking point prevalence is significantly higher than Siraiki speaking (p=0.028); Urdu speaking point prevalence is significantly higher than patients speaking Balochi (p=0.012), Pashto (p=0.002), Punjabi (p=0.002) and Siraiki (p=0.0001).
Conclusion: Allocation of resources are required at governmental and non-governmental level for early screening. National cancer registry program should also be initiated to support health policy makers for the development of counter strategies.

Peer Review History:
Received: 26 February 2023; Revised: 13 March; Accepted: 27 April 2023, Available online: 15 May 2023
Academic Editor: Prof. Cyprian Ogbonna ONYEJI, Obafemi Awolowo University, Ile-Ife, Nigeria, conyeji@oauife.edu.ng
Received file: Reviewer's Comments:
Average Peer review marks at initial stage: 5.5/10
Average Peer review marks at publication stage: 7.0/10
Reviewers:
Dr. Bilge Ahsen KARA, Ankara Gazi Mustafa Kemal Hospital, Turkey, ahsndkyc@gmail.com
Dr. A.A. Mgbahurike, University of Port Harcourt, Nigeria, amaka_mgbahurike@yahoo.com
NASAL ADMINISTRATION OF SILVER NANOPARTICLES AND SILVER IONS REDUCED COGNITIVE PERFORMANCE IN ADULT RATS
Authors: Farimaneh Javad , Tabandeh Mohammad Reza , Tabatabaei Seyed Reza Fatemi 
Published: May 2023

Background: Silver nanoparticles (AgNPs) have shown adverse effects and a toxic impact on human cell bodies. Passing the blood-brain barrier and increasing oxidative stress can change different parts of the brain such as the hippocampus. Therefore, the purpose of this investigation was to explore the possible neurotoxicity of AgNPs in adult rats.
Method: Neurotoxicity was created in rats by treating them with 15 mg/kg NP3 and silver ions (AgAc) intra-nasally every two days for 20 days. The animals were divided into five groups: control, vehicle, NP3, NP15, and AgAc. Behavioral assessments such as Morris water maze and elevated plus maze, and assessment of biomarkers such as malondialdehyde assay were used to evaluate cognitive impairment and molecular changes induced by silver.
Result: The results revealed that NP15 and AgAc significantly impaired spatial memory. Moreover, NP3, NP15, and AgAc increased anxiety in animals. Additionally, MDA was significantly increased by NP3 and NP15.
Conclusion: The findings showed that AgNPs and AgAc, particularly NP15, result in neurotoxicity and behavioral impairments.

Peer Review History:
Received: 26 February 2023; Revised: 13 March; Accepted: 28 April 2023, Available online: 15 May 2023
Academic Editor: Dr. Nuray Arı, Ankara University, Turkiye, ari@ankara.edu.tr
Received file: Reviewer's Comments:
Average Peer review marks at initial stage: 5.5/10
Average Peer review marks at publication stage: 7.0/10
Reviewers:
Dr. Sally A. El-Zahaby, Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, King Salman International University, Egypt, sally.elzahaby@yahoo.com
Dr. Robert Tungadi, State University of Gorontalo, Indonesia, rtungadi@yahoo.com
BIMBINGAN KELOMPOK MELALUI TEKNIK SOSIODAMA TERHADAP PERILAKU PROSOSIAL SISWA KELAS X SMK NUSA BHAKTI BANDUNG PADA MASA PANDEMI
Authors: Syarifien Muhammad Adhika Rizqiansyah , Rohaeti Euis Eti , Novianti Williya 
Published: May 2023

This study aims to determine how the implementation of group guidance services through sociodrama techniques for class X at SMK Nusa Bhakti in developing prosocial behavior. The type of research used is qualitative research. For the subject, students are selected according to the characteristics, namely students aged 15-16 years and students in class X who have less prosocial behavior. Data was collected by interviewing homeroom teachers, BK teachers, and students who had low and high prosocial behavior. The results show that students who have low prosocial behavior can understand that prosocial behavior is very important to have and apply in the surrounding environment, it can be seen from the behavior of students who previously did not have a sense of help with the surrounding environment after being given group guidance services with sociodrama techniques. the student becomes have a sense of help towards the surrounding environment. Group guidance services through sociodrama techniques can be used as a service that can assist in developing students' prosocial behavior at school.Keywords:Â Â Â group guidence, sociodrama, procosial behavior
LAYANAN BIMBINGAN KELOMPOK SECARA DARING MELALUI TEKNIK MODELING UNTUK KEPERCAYAAN DIRI SISWA SMA KELAS XI DI SMAN 1 GUNUNGHALU
Authors: Farihah Periana , Hidayat Wahyu , Alawiyah Tuti 
Published: May 2023

The purpose of this study was to determine the offer of online group counseling on the self-esteem of class XI students at SMA Negeri 1 Gununghalu. The design of this study used descriptive qualitative research methids. The subjects of this study were six students of class XI SMA Negeri 1 Gununghalu. This survey tool uses observation guides, interview guides, surveys, and documentation. Data analysis technigues used are data reduction, dan display, and data inference. The results obtained from the survey are changes in studentsâ€™ self-confidence after beibg given online group counseling services through modeling technology. One of the obstacles faced by BK teachers when implementing online group counseling services through modeling technology is the difficulty connectivity and networks. The results showed that online group counseling services can help bulid self-confidence through self-confidence modeling techniques of students.Keywords:Â Â Â Group Guidance, Modeling Techniques, self-Confidence
PENGEMBANGAN MODUL BIMBINGAN BELAJAR TENTANG PERILAKU PROKRASTINASI AKADEMIK PADA SISWA KELAS X SMAN 1 CIRANJANG
Authors: Yanti Laras Melinda , Sobari Teti , Pahlevi Reza 
Published: May 2023

The module is one of the printed-based teaching materials regarding a particular subject that is systematically arranged to make it easier for students to learn independently or with the guidance of educators easily and on target. Academic procrastination is an individual's self-regulation inability that causes behavioral tendencies to delay procrastinating in doing and completing school assignments until the next day. The purpose of this research is to know the development process, to know the feasibility according to experts and practitioners, to know student responses and the effectiveness of the tutoring module on academic procrastination behavior. This type of research is research and development using the Borg and Gall model which was adopted by Sugiyono. The participants in this study were media experts, material experts, BK practitioners and students of SMAN 1 Ciranjang consisting of 10 students who were involved in the product trial and 36 students who were involved in the usage trial. The results show that the product that needs to be developed at SMAN 1 Ciranjang is a tutoring module about academic procrastination behavior, the product developed according to media experts is at a percentage of 90.6% with a very decent representation, according to material experts it is at a percentage of 95.2% with a very decent representation and according to BK practitioners the product is at a percentage of 96.9% with a very decent representation, the product developed has a very good response from students and the product developed is effective in reducing the level of student academic procrastination behavior.Keywords:Â Development, Tutoring Module, Academic Procrastination Behavior
Deoxysphingolipids: Atypical Skeletal Muscle Lipids Related to Insulin Resistance in Humans That Decrease Insulin Sensitivity In Vitro
Authors: Zarini Simona , Zemski Berry Karin A. , Kahn Darcy E. , Garfield Amanda , Perreault Leigh , Kerege Anna , Bergman Bryan C. 
Published: May 2023

Sphingolipids are thought to promote skeletal muscle insulin resistance. Deoxysphingolipids (dSLs) are atypical sphingolipids that are increased in the plasma of individuals with type 2 diabetes and cause β-cell dysfunction in vitro. However, their role in human skeletal muscle is unknown. We found that dSL species are significantly elevated in muscle of individuals with obesity and type 2 diabetes compared with athletes and lean individuals and are inversely related to insulin sensitivity. Furthermore, we observed a significant reduction in muscle dSL content in individuals with obesity who completed a combined weight loss and exercise intervention. Increased dSL content in primary human myotubes caused a decrease in insulin sensitivity associated with increased inflammation, decreased AMPK phosphorylation, and altered insulin signaling. Our findings reveal a central role for dSL in human muscle insulin resistance and suggest dSLs as therapeutic targets for the treatment and prevention of type 2 diabetes.

Article Highlights
Deoxysphingolipids (dSLs) are atypical sphingolipids elevated in the plasma of individuals with type 2 diabetes, and their role in muscle insulin resistance has not been investigated. We evaluated dSL in vivo in skeletal muscle from cross-sectional and longitudinal insulin-sensitizing intervention studies and in vitro in myotubes manipulated to synthesize higher dSLs. dSLs were increased in the muscle of people with insulin resistance, inversely correlated to insulin sensitivity, and significantly decreased after an insulin-sensitizing intervention; increased intracellular dSL concentrations cause myotubes to become more insulin resistant. Reduction of muscle dSL levels is a potential novel therapeutic target to prevent/treat skeletal muscle insulin resistance.
Measuring Meaningful English Learning Through Video Production: An Instrument Development Report
Authors: Mahardika I Gusti Ngurah Agung Wijaya , Suwastini Ni Komang Arie 
Published: May 2023

Students’ low motivation in learning English as a foreign language is an age-old problem for English teachers. To overcome this problem teacher must design and present the learning process in such way which minimize students’ fear and anxiety. One of the more interesting ways to teach English is to use videos in class. The present study aims at developing an instrument to measure students’ perception of the meaningfulness of English learning using video production. This instrument is developed to facilitate the measurement of students’ perception of the meaningfulness of English learning using video. The construct used as the basis of the instrument development is the Meaningful Learning using digital media and video proposed by Paivi Karppinen. The instrument is developed using Borg’s seven steps instrument development process which includes defining the construct to be measured, defining the target population, reviewing related test, developing prototypes (blueprint and test items), evaluating the prototype, revising the instrument, and collecting data on the validity and reliability of the instrument. The final product consists of 23 items, measuring the 6 sub-constructs with Cronbach’s Alpha Value and the Cronbach’s Alpha Based on Standardized items values of .0903 and 0.932 respectively.
PEMBERDAYAAN MASYARAKAT NELAYAN; PERAN DAN KONTRIBUSI DINAS PERIKANAN DAN KELAUTAN
Authors: Sitorus Siti Hazar , Fatkhullah Mukhammad 
Published: May 2023

Penelitian ini bertujuan untuk mengetahui peran dan kontribusi Dinas Perikanan dan Kelautan Kabupaten Rokan Hilir dalam pemberdayaan melalui kebijakan dan program kerja pada kurun waktu 2016-2018. Penelitian ini menggunakan metode kualitatif-deskriptif, dengan wawacara, observasi dan kajian pustaka sebagai instrumennya. Hasil penelitian menunjukkan bahwa dari 10 program dan 61 kegiatan, peran Dinas Perikanan dan Kelautan Kabupaten Rokan Hilir dalam pemberdayaan masyarakat dapat dilihat melalui: (1) Program Pemberdayaan Ekonomi Masyarakat Pesisir, (2) Program Peningkatan Budaya Kelautan dan Wawasan Maritim kepada Masyarakat, (3) Program Pengembangan Budidaya Perikanan, (4) Program Pengembangan Perikanan Tangkap, serta (5) Program Optimalisasi Pengelolaan dan Pemasaran Produksi Perikanan. Berdasarkan perbandingan dari tahun ke-tahun, program pemberdayaan masyarakat nelayan oleh Dinas Perikanan dan Kelautan Kabupaten Rokan Hilir mampu meningkatkan produktivitas perikanan budidaya sebesar 6%. Peningkatan terbesar terdapat pada budidaya ikan kolam dengan nilai peningkatan sebesar 108%. Meskipun demikian, terdapat penurunan produktivitas pada budidaya tambak sebesar 24%.