bluuebunny/crossref_metadata_2025_split huggingface dataset:
Glucocorticoids increase tissue cell protection against pore-forming toxins from pathogenic bacteria
Authors: Ormsby Thomas J. R. , Owens Sian E. , Turner Matthew L. , Cronin James G. , Bromfield John J. , Sheldon I. Martin 
Published: February 2023

AbstractMany species of pathogenic bacteria damage tissue cells by secreting toxins that form pores in plasma membranes. Here we show that glucocorticoids increase the intrinsic protection of tissue cells against pore-forming toxins. Dexamethasone protected several cell types against the cholesterol-dependent cytolysin, pyolysin, from Trueperella pyogenes. Dexamethasone treatment reduced pyolysin-induced leakage of potassium and lactate dehydrogenase, limited actin cytoskeleton alterations, reduced plasma membrane blebbing, and prevented cytolysis. Hydrocortisone and fluticasone also protected against pyolysin-induced cell damage. Furthermore, dexamethasone protected HeLa and A549 cells against the pore-forming toxins streptolysin O from Streptococcus pyogenes, and alpha-hemolysin from Staphylococcus aureus. Dexamethasone cytoprotection was not associated with changes in cellular cholesterol or activating mitogen-activated protein kinase (MAPK) cell stress responses. However, cytoprotection was dependent on the glucocorticoid receptor and 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase (HMGCR). Collectively, our findings imply that glucocorticoids could be exploited to limit tissue damage caused by pathogens secreting pore-forming toxins.
A multi-timescale synaptic weight based on ferroelectric hafnium zirconium oxide
Authors: Halter Mattia , Bégon-Lours Laura , Sousa Marilyne , Popoff Youri , Drechsler Ute , Bragaglia Valeria , Offrein Bert Jan 
Published: February 2023

AbstractBrain-inspired computing emerged as a forefront technology to harness the growing amount of data generated in an increasingly connected society. The complex dynamics involving short- and long-term memory are key to the undisputed performance of biological neural networks. Here, we report on sub-µm-sized artificial synaptic weights exploiting a combination of a ferroelectric space charge effect and oxidation state modulation in the oxide channel of a ferroelectric field effect transistor. They lead to a quasi-continuous resistance tuning of the synapse by a factor of $$60$$
60
and a fine-grained weight update of more than $$200$$
200
resistance values. We leverage a fast, saturating ferroelectric effect and a slow, ionic drift and diffusion process to engineer a multi-timescale artificial synapse. Our device demonstrates an endurance of more than $${10}^{10}$$

10

10

cycles, a ferroelectric retention of more than $$10$$
10
years, and various types of volatility behavior on distinct timescales, making it well suited for neuromorphic and cognitive computing.
Native Language Perceptual Sensitivity Predicts Nonnative Speech Perception Differently in Younger and Older Singaporean Bilinguals
Authors: Kalaivanan Kastoori , Wong Patrick C. M. , Wong Francis C. K. , Chan Alice H. D. 
Published: February 2023

Purpose:

We investigate in this study how individual variability in native language speech perception (termed
Perceptual Sensitivity
) influences nonnative speech perception in Singaporean Tamil–English bilinguals. Further, we assess if and how contextual and demographic factors influence Perceptual Sensitivity in the acquired languages and if the influence of Perceptual Sensitivity on nonnative speech perception is different across younger and older bilinguals.

Method:
Perceptual Sensitivity in the native languages was examined by implementing Tamil and English gating tasks in 87 Singaporean Tamil–English bilinguals from two age groups (younger: 19–33 years; older: 55–70 years). Mandarin lexical tone discrimination was implemented as a measure of nonnative speech perception.

Results:
There was a wide range of variability in Perceptual Sensitivity scores in both languages across both age groups. Perceptual Sensitivity in the first native language (L1 Tamil) was a robust predictor of nonnative speech perception across both age groups, especially for the older bilinguals. However, general intelligence emerged as a stronger predictor than Tamil Perceptual Sensitivity in younger bilinguals. The influence of Tamil Perceptual Sensitivity on lexical tone perception was not tone-specific, supporting a general enhancement of lexical tone perception with better Tamil Perceptual Sensitivity. There was an influence of demographic factors on English Perceptual Sensitivity in older bilinguals, but not for Tamil and not in younger bilinguals.

Conclusions:
Our findings corroborate with previous studies in showing that native language Perceptual Sensitivity is positively associated with and predicts nonnative speech perception in younger and older adulthood regardless of language similarity but to varying degrees. Specifically, the influence of Perceptual Sensitivity on nonnative speech perception is stronger in older adulthood, suggesting a possible shift in reliance on crystallized language knowledge with age. Proficiency and use, among other demographic and language variables, do not appear to influence L1 Perceptual Sensitivity in a lesser used language (Tamil) as significantly as previously assumed.
Deeply‐Recursive Attention Network for video steganography
Authors: Cui Jiabao , Zheng Liangli , Yu Yunlong , Lin Yining , Ni Huajian , Xu Xin , Zhang Zhongfei 
Published: February 2023

AbstractVideo steganography plays an important role in secret communication that conceals a secret video in a cover video by perturbing the value of pixels in the cover frames. Imperceptibility is the first and foremost requirement of any steganographic approach. Inspired by the fact that human eyes perceive pixel perturbation differently in different video areas, a novel effective and efficient Deeply‐Recursive Attention Network (DRANet) for video steganography to find suitable areas for information hiding via modelling spatio‐temporal attention is proposed. The DRANet mainly contains two important components, a Non‐Local Self‐Attention (NLSA) block and a Non‐Local Co‐Attention (NLCA) block. Specifically, the NLSA block can select the cover frame areas which are suitable for hiding by computing the correlations among inter‐ and intra‐cover frames. The NLCA block aims to effectively produce the enhanced representations of the secret frames to enhance the robustness of the model and alleviate the influence of different areas in the secret video. Furthermore, the DRANet reduces the model parameters by performing similar operations on the different frames within an input video recursively. Experimental results show the proposed DRANet achieves better performance with fewer parameters than the state‐of‐the‐art competitors.
High-angular-resolution NIR view of the Orion Bar revealed by Keck/NIRC2
Authors: Habart Emilie , Le Gal Romane , Alvarez Carlos , Peeters Els , Berné Olivier , Wolfire Mark G. , Goicoechea Javier R. , Schirmer Thiébaut , Bron Emeric , Röllig Markus 
Published: February 2023

Context. Nearby photo-dissociation regions (PDRs), where the gas and dust are heated by the far-ultraviolet (FUV) irradiation emitted from stars, are ideal templates with which to study the main stellar feedback processes.
Aims. With this study, we aim to probe the detailed structures at the interfaces between ionized, atomic, and molecular gas in the Orion Bar. This nearby prototypical strongly irradiated PDR are among the first targets of the James Webb Space Telescope (JWST) within the framework of the PDRs4All Early Release Science program.
Methods. We employed the subarcsecond resolution accessible with Keck-II NIRC2 and its adaptive optics system to obtain images of the vibrationally excited line H2 1−0 S(1) at 2.12 µm that are more detailed and complete than ever before. H2 1−0 S(1) traces the dissociation front (DF), and the [FeII] and Brγ lines, at 1.64 and 2.16 µm, respectively, trace the ionization front (IF). The former is a powerful tracer of the FUV radiation field strength and gas density distribution at the PDR edge, while the last two trace the temperature and density distribution from the ionized gas to the PDR. We obtained narrow-band filter images in these key gas line diagnostics over ~40″ at spatial scales of ~0.1″ (~0.0002 pc or ~40 AU at 414 pc).
Results. The Keck/Near Infrared Camera 2 (NIRC2) observations spatially resolve a plethora of irradiated substructures such as ridges, filaments, globules, and proplyds. This portends what JWST should accomplish and how it will complement the highest resolution Atacama Large Millimeter/submillimeter Array (ALMA) maps of the molecular cloud. We observe a remarkable spatial coincidence between the H2 1−0 S(1) vibrational and HCO+ J = 4−3 rotational emission previously obtained with ALMA. This likely indicates the intimate link between these two molecular species and highlights that in high-pressure PDRs, the H/H2 and C+/C/CO transitions zones come closer than in a typical layered structure of a constant density PDR. The H/H2 dissociation front appears as a highly structured region containing substructures with a typical thickness of a few ~10−3 pc.
A machine learning approach for correcting radial velocities using physical observables
Authors: Perger M. , Anglada-Escudé G. , Baroch D. , Lafarga M. , Ribas I. , Morales J. C. , Herrero E. , Amado P. J. , Barnes J. R. , Caballero J. A. , Jeffers S. V. , Quirrenbach A. , Reiners A. 
Published: February 2023

Context. Precision radial velocity (RV) measurements continue to be a key tool for detecting and characterising extrasolar planets. While instrumental precision keeps improving, stellar activity remains a barrier to obtaining reliable measurements below 1–2 m s−1 accuracy.
Aims. Using simulations and real data, we investigate the capabilities of a deep neural network approach to producing activity-free Doppler measurements of stars.
Methods. As case studies we used observations of two known stars, ϵ Eridani and AU Microscopii, both of which have clear signals of activity-induced Doppler variability. Synthetic observations using the starsim code were generated for the observables (inputs) and the resulting Doppler signal (labels), and then they were used to train a deep neural network algorithm to predict Doppler corrections. We identified a relatively simple architecture, consisting of convolutional layers followed by fully connected layers, that is adequate for the task. The indices investigated are mean line-profile parameters (width, bisector, and contrast) and multi-band photometry.
Results. We demonstrate that the RV-independent approach can drastically reduce spurious Doppler variability from known physical effects, such as spots, rotation, and convective blueshift. We identify the combinations of activity indices with the most predictive power. When applied to real observations, we observe a good match of the correction with the observed variability, but we also find that the noise reduction is not as good as in the simulations, probably due to a lack of detail in the simulated physics.
Conclusions. We demonstrate that a model-driven machine learning approach is sufficient to clean Doppler signals from activity-induced variability for well-known physical effects. There are dozens of known activity-related observables whose inversion power remains unexplored, indicating that the use of additional indicators, more complete models, and more observations with optimised sampling strategies can lead to significant improvements in our detrending capabilities for new and existing datasets.
Pathways of survival for exomoons and inner exoplanets
Authors: Makarov Valeri V. , Efroimsky Michael 
Published: February 2023

Context. It is conceivable that a few thousand confirmed exoplanets initially harboured satellites similar to the moons of the Solar System or larger. We ask the question of whether some of them have survived over the æons of dynamical evolution to the present day. The dynamical conditions are harsh for exomoons in such systems because of the greater influence of the host star and of the tidal torque it exerts on the planet.
Aims. We investigate the stability niches of exomoons around hundreds of innermost exoplanets for which the needed parameters are known today, and we determine the conditions of these moons’ long-term survival. General lower and upper bounds on the exomoon survival niches are derived for orbital separations, periods, and masses.
Methods. The fate of an exomoon residing in a stability niche depends on the initial relative rate of the planet’s rotation and on the ability of the moon to synchronise the planet by overpowering the tidal action from the star. State-of-the-art models of tidal dissipation and secular orbital evolution are applied to a large sample of known exoplanet systems, which have the required estimated physical parameters.
Results. We show that in some plausible scenarios, exomoons can prevent close exoplanets from spiralling into their host stars, thus extending these planets’ lifetimes. This is achieved when exomoons synchronise the rotation of their parent planets, overpowering the tidal action from the stars.
Conclusions. Massive moons are more likely to survive and help their host planets maintain a high rotation rate (higher than these planets’ mean motion).
Prix Nobel de physiologie ou médecine 2022
Authors: Heyer Evelyne 
Published: February 2023

Svante Pääbo s’est vu attribuer le prix Nobel de physiologie ou médecine en 2022 pour ses travaux en paléogénétique. Né le 20 avril 1955 à Stockholm, Svante Pääbo a soutenu sa thèse de doctorat en 1986 à l’université d’Uppsala en Suède. Après plusieurs séjours post-doctoraux en Suisse (Institute for Molecular Biology, University of Zürich), puis aux États-Unis (Department of Biochemistry, University of California at Berkeley), il a été nommé professeur de biologie à l’université de Munich en Allemagne. En 1997, il fonde un centre de recherche en paléogénétique au sein de l’Institut Max Planck d’anthropologie évolutionniste à Leipzig en Allemagne. Là, grâce à des soutiens financiers importants, il développe un tout nouveau champ disciplinaire : la paléogénomique humaine, une nouvelle science qui consiste en l’extraction, la lecture et l’analyse de l’ADN dans des restes de fossiles humains afin d’en déterminer l’histoire.
Don du corps à la science
Authors: Moutel Grégoire , Gouriot Mylène , Suzat Bertille , Batteur Annick , Ploteau Stéphane , Destrieux Christophe , Grandazzi Guillaume 
Published: February 2023

En France, entre 2 500 et 3 000 personnes donnent leur corps à la science chaque année après leur mort ; elles contribuent ainsi à l’enseignement de l’anatomie, à la recherche et à l’apprentissage et l’amélioration des pratiques chirurgicales. La décision doit être prise de son vivant et le consentement exprimé par écrit auprès d’un des vingt-sept centres de don du corps répartis sur le territoire national. Suite au scandale du centre parisien des Saints-Pères, le décret du 27 avril 2022 relatif au don de corps à des fins d’enseignement et de recherche, qui s’inscrit dans le cadre des nouvelles lois de bioéthique, était très attendu pour clarifier certaines pratiques. Mais ce décret soulève de nouvelles questions car nombreuses sont les règles qu’il propose qui ne nous apparaissent pas pertinentes au regard des valeurs du don et du fonctionnement des centres de don. Les nouveaux modes de régulation proposés génèrent des questions chez les donneurs et les professionnels de terrain avec un risque de mauvaise régulation. Nous pensons que si la puissance publique ne s’engage pas dans une régulation plus adaptée au terrain, si les enjeux éthiques ne sont pas mieux clarifiés et si les universités n’ont pas les moyens pour mettre en œuvre ces nouvelles organisations, la pérennisation du don du corps et des centres de don pourrait devenir difficile.
Role of Neural Plasticity of Motor Cortex in Gliomas Evaluated by Brain Imaging and Mapping Techniques in Pre- and Postoperative Period: A Systematic Review
Authors: Silva Rhuann Pontes dos Santos , Monteiro Lucas Nascimento , Dias Lavinia da Silva , Haddad Julia Oliveira Dabien , souza Vitor Bidu de , Oliveira Vinicius Faustino Lima de , Fernandes Anna Sabrinny , Olivera Matheus Fernandes de , Rotta Jose Marcus 
Published: February 2023

Abstract
Background Resection of infiltrative neuroepithelial primary brain tumors, such as low-grade gliomas (LGGs) remains a neurosurgical challenge. Usual lack of clinical deficit despite LGGs growing in eloquent brain areas may be explained by reshaping and reorganization of functional networks. The development of modern diagnostic imaging techniques could disclose better understanding of the rearrangement of the brain cortex; however, mechanisms underlying such compensation and how it occurs in the motor cortex remain unclear. This systematic review aims to analyze the neuroplasticity of motor cortex in patients with LGGs, as determined by neuroimaging and functional techniques.
Methods Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, medical subject headings (MeSH) and the following terms related to neuroimaging, LGGs and neuroplasticity were used with the Boolean operators AND and OR to synonymous terms in the PubMed database. Among the 118 results, 19 studies were included in the systematic review.
Results Motor function in patients with LGG was characterized by a compensation in the contralateral and supplementary motor areas and premotor functional networks. Furthermore, ipsilateral activation in these types of gliomas was rarely described. Moreover, some studies did not reveal statistical significance in association between functional reorganization and the postoperative period, which can be explained by the low number of patients.
Conclusion Our findings suggest a high pattern of reorganization per different eloquent motor areas and gliomas diagnosis. Understanding this process is useful to guide safe surgical resection and to develop protocols that assess the plasticity, even though functional network rearrangement needs to be better characterized by more studies.
Long-term outcomes of pouch surveillance and risk of neoplasia in familial adenomatous polyposis
Authors: Patel Roshani V. , Curtius Kit , Man Ripple , Fletcher Jordan , Cuthill Victoria , Clark Susan K. , von Roon Alexander C. , Latchford Andrew 
Published: February 2023

Abstract
Background Long-term pouch surveillance outcomes for familial adenomatous polyposis (FAP) are unknown. We aimed to quantify surveillance outcomes and to determine which of selected possible predictive factors are associated with pouch dysplasia.
Methods Retrospective analysis of collected data on 249 patients was performed, analyzing potential risk factors for the development of adenomas or advanced lesions ( ≥ 10 mm/high grade dysplasia (HGD)/cancer) in the pouch body and cuff using Cox proportional hazards models. Kaplan–Meier analyses included landmark time-point analyses at 10 years after surgery to predict the future risk of advanced lesions.
Results Of 249 patients, 76 % developed at least one pouch body adenoma, with 16 % developing an advanced pouch body lesion; 18 % developed an advanced cuff lesion. Kaplan–Meier analysis showed a 10-year lag before most advanced lesions developed; cumulative incidence of 2.8 % and 6.4 % at 10 years in the pouch body and cuff, respectively. Landmark analysis suggested the presence of adenomas prior to the 10-year point was associated with subsequent development of advanced lesions in the pouch body (hazard ratio [HR] 4.8, 95 %CI 1.6–14.1; P = 0.004) and cuff (HR 6.8, 95 %CI 2.5–18.3; P < 0.001). There were two HGD and four cancer cases in the cuff and one pouch body cancer; all cases of cancer/HGD that had prior surveillance were preceded by ≥ 10-mm adenomas.
Conclusions Pouch adenoma progression is slow and most advanced lesions occur after 10 years. HGD and cancer were rare events. Pouch phenotype in the first decade is associated with the future risk of developing advanced lesions and may guide personalized surveillance beyond 10 years.
Selective Vesical Artery Embolization in Refractory BK Virus Hemorrhagic Cystitis
Authors: Kumar Saurabh , Bhargava Rahul , Kumar Meet , Dua Vikas , Santosh Santosh 
Published: February 2023

AbstractIn hematopoietic stem cell transplantation (HSCT) recipients, BK virus-related hemorrhagic cystitis is a well-known complication. It increases the risk of death and morbidity of HSCT recipients with simultaneous increase in healthcare cost burden, as a result of prolonged hospital admissions. There are many conservative therapeutic strategies available for the treatment that are effective in treatment of milder forms of hemorrhagic cystitis. Vesical artery embolization is one of the nonsurgical bailout procedure in patient's refractory to medical therapy with added advantage of avoidance of high-risk definitive surgical procedure of cystectomy or urinary diversion in these critical immunosuppressed patients.
Imaging-Guided Percutaneous Transperitoneal Balloon Fenestration of Postrenal Transplant Lymphocele: A Case Report of Experience with New Technique
Authors: Zuber Mohammad , Shoaib Mohammad , Chatterjee Pritam , Ravikumar R. 
Published: February 2023

AbstractRenal transplantation is the treatment of choice for improved survival and quality of life in patients with end-stage renal disease. However, perirenal fluid collections are common surgical complications after renal transplant, with about 0.6 to 18% of patients developing a lymphocele. Conventional treatments include percutaneous aspiration and drainage, laparoscopic fenestration, and open surgical decompression stepwise. Recently, a new image-guided percutaneous transperitoneal balloon fenestration technique has been described as an alternative to the laparoscopic or surgical technique. We present the case of a 25-year-old male patient diagnosed with a lymphocele after 2 months of transplantation and no resolution of the lymphocele with percutaneous aspiration and drainage. We used this new technique under ultrasound and fluoroscopy guidance, which resulted in the resolution of the lymphocele at 1 month postprocedure. This case report highlights this new technique's potential role in successfully managing the posttransplant lymphocele in a minimally invasive manner.