bluuebunny/crossref_metadata_2025_split huggingface dataset:
Patients’ perspective of quality-of-care and its correlation to quality-of-life following spontaneous coronary artery dissection
Authors: Dang Quan , Murphy Barbara , Graham Robert M , Puri Aniket , Ford Sarah , Marschner Simone , Chong James J H , Zaman Sarah 
Published: September 2023

Abstract

Aims
Spontaneous coronary artery dissection (SCAD) is an under-recognized cause of myocardial infarction. We aimed to investigate SCAD survivors’ perceptions of their quality-of-care and its relationship to quality-of-life.

Methods and results
An anonymous survey was distributed online to SCAD survivors involved in Australian SCAD support groups, with 172 (95.3% female, mean age 52.6 ± 9.2 years) participants in the study. The survey involved assessment of quality-of-life using a standardized questionnaire (EQ-5DTM-3L). Respondents rated the quality-of-care received during their hospital admission for SCAD with a median of 8/10 [interquartile range (IQR) 7–10]. Respondents ≤ 50 years vs. &gt;50 years were more likely to perceive that their symptoms were not treated seriously as a myocardial infarction (χ2 = 4.127, df = 1, P &lt; 0.05). Participants rated clinician’s knowledge of SCAD with a median of 4/10 (IQR 2–8) and 7/10 (IQR 3–9) for Emergency and Cardiology clinicians, respectively (P &lt; 0.05). The internet was the most selected source (45.4%) of useful SCAD information. The mean EQ-5DTM summary index was 0.79 (population norm 0.87). A total of 47.2% of respondents reported a mental health condition diagnosis, with 36% of these diagnosed after their admission with SCAD. Quality-of-life was significantly associated with perceived quality-of-care: EQ-5DTM index/(1-EQ-5DTM index) increased by 13% for each unit increase in quality-of-care after adjusting for age and comorbidities (P &lt; 0.001).

Conclusion
While SCAD survivors rated their overall hospital care highly, healthcare providers’ knowledge of SCAD was perceived to be poor, and the most common source of SCAD information was the internet. Mental health conditions were common, and a significant association was observed between perceived quality-of-care and SCAD survivors’ quality-of-life.
Naringin, neohesperidin and their corresponding dihydrochalcones as bioactive substances: a symphony of bitter–sweet
Authors: Wang Ruoqi , You Wenwen , Lin Heng , Cao Yunlin , Xu Changjie , Chen Kunsong , Liu Yilong , Li Xian 
Published: September 2023

Abstract
Bitter is generally undesirable, although it is an important part of flavor. Bitter substances exhibit diverse health-promoting activities, which is in line with the famous Chinese saying ‘a good medicine tastes bitter’. Naringin (NAG) and neohesperidin (NHP), two important flavanones that give bitterness to citrus fruits, show various pharmacological activities. Interestingly, their hydrogenation products, i.e. naringin dihydrochalcone (NDC) and neohesperidin dihydrochalcone (NHDC), undergo a dramatic taste shift from bitter to intensely sweet, which can be 300 and 1000 times sweeter than sucrose, respectively. Such sweeteners not only provide a sweet taste without the burden of increased calorie intake and glycemia, but also may exert multiple bioactivities. This review summarizes common dietary bitter and sweet compounds with sensory scores. Taste conversions induced by structural changes from bitter NAG and NHP to sweet NDC and NHDC are particularly discussed. In addition, the taste-sensing mechanisms, pharmacological characteristics, dietary distribution, synthesis, and food industry applications of these bitter–sweet interchangeable compounds are outlined. In conclusion, the bitter NAG and NHP are promising therapeutic candidates for management of diverse etiologically complex diseases while their corresponding dihydrochalcones NDC and NHDC are promising sweeteners, which might be a blessing for those who need to control sugar intake.
Hedgehog signaling guides migration of primordial germ cells to the Drosophila somatic gonad
Authors: Deshpande Girish , Ng Chris , Jourjine Nicholas , Chiew Joy Wan , Dasilva Juliana , Schedl Paul 
Published: September 2023

Abstract
In addition to inducing nonautonomous specification of cell fate in both Drosophila and vertebrates, the Hedgehog pathway guides cell migration in a variety of different tissues. Although its role in axon guidance in the vertebrate nervous system is widely recognized, its role in guiding the migratory path of primordial germ cells (PGCs) from the outside surface of the Drosophila embryo through the midgut and mesoderm to the SGPs (somatic gonadal precursors) has been controversial. Here we present new experiments demonstrating (1) that Hh produced by mesodermal cells guides PGC migration, (2) that HMG CoenzymeA reductase (Hmgcr) potentiates guidance signals emanating from the SGPs, functioning upstream of hh and of 2 Hh pathway genes important for Hh-containing cytonemes, and (3) that factors required in Hh receiving cells in other contexts function in PGCs to help direct migration toward the SGPs. We also compare the data reported by 4 different laboratories that have studied the role of the Hh pathway in guiding PGC migration.
An approach to remove the numerical dispersion in elastic wave modeling using R-Cycle-GAN networks
Authors: Zheng Wanqiu , Wang Jian , Meng Xiaohong 
Published: September 2023

Abstract
The finite difference forward modeling has been widely used in geophysics exploration and petroleum fields. Because of its high efficiency and easy application for graphical processing units, it has been widely concerned by industry and academia. However, owing to many factors, the problem of numerical dispersion has been an important factor hindering this method. To overcome the numerical dispersion, this paper proposes a method for removing numerical dispersion using deep learning. Unlike the conventional optimized algorithms target to optimize the finite difference coefficients, our strategy is based on big data training to eliminate the dispersion data after seismic data modeling. We design a neural network architecture based on cycle-consistent generative adversarial networks (Cycle-GANs) and residual learning for elastic wave propagation. Under the premise of not significantly increasing the calculation time, we can obtain higher calculation accuracy. Compared with the high-order finite difference algorithm, the calculation time is the advantage of our proposed deep learning method. Tests prove the efficiency and stability of our proposed algorithm.
Powers Correlation Analysis of Returns with a Non-stationary Zero-Process
Authors: Patilea Valentin , Raïssi Hamdi 
Published: September 2023

Abstract
The higher order dynamics of individual stocks is investigated. We show that classical powers correlation analysis can lead to a spurious assessment of the volatility persistence or long memory volatility effects, if the zero return probability is non-constant over time. In other words, classical tools are not able to distinguish between long-run volatility effects, such as IGARCH, and the case where the zero returns are not evenly distributed over time. As a remedy, new diagnostic tools are proposed that are robust to changes in the zero return probability. Since a time-varying zero return probability could potentially be accompanied by a non-constant unconditional variance, we also develop powers correlation analysis that is robust in such a case. In addition, the diagnostic tools we propose offer a rigorous analysis of the short-run volatility effects, while the use of the classical powers correlations lead to doubtful conclusions. Monte Carlo experiments, and the study of the absolute value correlation of daily returns taken from the Chilean financial market and the 1-min returns of Facebook stocks, suggest that the volatility effects are only short-run in many cases.
Multiscale influences on Elk (Cervus canadensis) calving site selection across a fragmented Appalachian landscape
Authors: Hooven Nathan D , Williams Kathleen E , Hast John T , McDermott Joseph R , Crank R Daniel , Springer Matthew T , Cox John J 
Published: September 2023

Abstract
Due to the vulnerability of neonatal ungulates, selection of a birth site can have important implications for offspring survival and thus fitness of the mother. We studied parturition site selection in cow Elk in southeastern Kentucky, United States, using a use–availability framework to evaluate the effects of landscape variables sampled at multiple spatial grains on the relative probability of use of parturition sites. We identified 81 Elk parturition sites during May–Aug 2020–2022 and fit several candidate resource selection function models using a sample of 24,314 random locations to characterize habitat availability. Using an information-theoretic approach to rank candidate models, we identified two top-performing models (cumulative ωi = 0.97), which indicated that at fine spatial grains (~10- and 30-m pixels) parturient cow Elk selected for intermediate canopy cover and lower terrain ruggedness compared to available locations. At coarse grains (250–1,000-m buffers/neighborhoods), Elk selected against vegetation greenness/biomass, for higher topographic positions, for closer proximity to major roads, and with higher solar radiation potential. We also found evidence that Elk responded positively to forest/open edge densities at coarse grains, demonstrating that calving habitat throughout the Kentucky Elk Restoration Zone is associated with heterogeneous landscapes resulting from surface mine reclamation. As a result, habitat management actions should aim to increase patchy, early successional shrub cover on gentle topography.
Education and Formation in an Interwar Hasidic Yeshiva: The Case of Tomkhe Temimim Warsaw
Authors: Tworek Wojciech 
Published: September 2023

Abstract
Hasidic yeshivas rose to prominence in Eastern Europe in the interwar period (1918–1939), as a way of keeping orthodox youth in the fold and of shaping the new generations of Hasidim, enabling them to withstand the allures of non-Orthodox cultures. Using the Chabad–Lubavitch yeshiva Tomkhe Temimim as a case study, this article focuses on the educational and formative strategies employed in interwar Hasidic yeshivas. It examines previously unused internal yeshiva sources, such as student lists or teachers’ reports, to show the pedagogical practices of the yeshiva staff and faculty. Effectively, the article provides an egalitarian and down-to-earth perspective on the Hasidic transformation in the interwar years. This perspective goes beyond the theoretical Hasidic concepts preached by the leaders to show how, in practical terms, these concepts were understood by the movement’s secondary intelligentsia and passed on to the next generation in the movement’s formative institutions.
Goreisan as a successful adjuvant therapy of heart failure with preserved ejection fraction and advanced chronic kidney disease: a case report
Authors: Sugihara Ryuta , Hashimura Tatsuro , Sakata Yasushi 
Published: September 2023

Abstract
Atrial functional mitral and tricuspid regurgitation due to atrial fibrillation (AF) are common causes of heart failure with preserved ejection fraction, but standard treatment with conventional diuretics can often lead to renal dysfunction. Kampo Goreisan, a traditional Eastern-Asian herbal medicine that regulates body water balance via the aquaporin-incorporated water reabsorption system can be used as an alternative therapy without causing renal burden. In this report, we describe a case of successful treatment with Goreisan of heart failure with preserved ejection fraction (HFpEF) due to atrial functional mitral and tricuspid regurgitation (AFMR/TR) receiving guideline-directed medical-therapy. Goreisan could afford amelioration of regurgitation and improvement bilateral systolic ventricular function without renal dysfunction. Thus, Goreisan may be a promising therapeutic option for patients refractory to conventional diuretics.
Comparative analysis of nascent RNA sequencing methods and their applications in studies of cotranscriptional splicing dynamics
Authors: Liu Min , Zhu Jiafu , Huang Huijuan , Chen Yan , Dong Zhicheng 
Published: September 2023

Abstract
High-throughput detection of nascent RNA is critical for studies of transcription and much more challenging than that of mRNA. Recently, several massively parallel nascent RNA sequencing methods were established in eukaryotic cells. Here, we systematically compared 3 classes of methods on the same pure or crude nuclei preparations: GRO-seq for sequence nuclear run-on RNAs, pNET-seq for sequence RNA polymerase II-associated RNAs, and CB RNA-seq for sequence chromatin-bound (CB) RNAs in Arabidopsis (Arabidopsis thaliana). To improve the resolution of CB RNAs, 3′CB RNA-seq was established to sequence the 3′ ends of CB RNAs. In addition, we modified pNET-seq to establish the Chromatin Native Elongation Transcript sequencing (ChrNET) method using chromatin as the starting material for RNA immunoprecipitation. Reproducibility, sensitivity and accuracy in detecting nascent transcripts, experimental procedures, and costs were analyzed, which revealed the strengths and weaknesses of each method. We found that pNET and GRO methods best detected active RNA polymerase II. CB RNA-seq is a simple and cost-effective alternative for nascent RNA studies, due to its high correlation with pNET-seq and GRO-seq. Compared with pNET, ChrNET has higher specificity for nascent RNA capture and lower sequencing cost. 3′CB is sensitive to transcription-coupled splicing. Using these methods, we identified 1,404 unknown transcripts, 4,482 unannotated splicing events, and 60 potential recursive splicing events. This comprehensive comparison of different nascent/chromatin RNA sequencing methods highlights the strengths of each method and serves as a guide for researchers aiming to select a method that best meets their study goals.
The right inferior frontal gyrus as pivotal node and effective regulator of the basal ganglia-thalamocortical response inhibition circuit
Authors: Zhuang Qian , Qiao Lei , Xu Lei , Yao Shuxia , Chen Shuaiyu , Zheng Xiaoxiao , Li Jialin , Fu Meina , Li Keshuang , Vatansever Deniz , Ferraro Stefania , Kendrick Keith M , Becker Benjamin 
Published: September 2023

Abstract

Background
The involvement of specific basal ganglia-thalamocortical circuits in response inhibition has been extensively mapped in animal models. However, the pivotal nodes and directed causal regulation within this inhibitory circuit in humans remains controversial.

Objective
The main aim of the present study was to determine the causal information flow and critical nodes in the basal ganglia-thalamocortical inhibitory circuits and also to examine whether these are modulated by biological factors (i.e. sex) and behavioral performance.

Methods
Here, we capitalize on the recent progress in robust and biologically plausible directed causal modeling (DCM-PEB) and a large response inhibition dataset (n = 250) acquired with concomitant functional magnetic resonance imaging to determine key nodes, their causal regulation and modulation via biological variables (sex) and inhibitory performance in the inhibitory circuit encompassing the right inferior frontal gyrus (rIFG), caudate nucleus (rCau), globus pallidum (rGP), and thalamus (rThal).

Results
The entire neural circuit exhibited high intrinsic connectivity and response inhibition critically increased causal projections from the rIFG to both rCau and rThal. Direct comparison further demonstrated that response inhibition induced an increasing rIFG inflow and increased the causal regulation of this region over the rCau and rThal. In addition, sex and performance influenced the functional architecture of the regulatory circuits such that women displayed increased rThal self-inhibition and decreased rThal to GP modulation, while better inhibitory performance was associated with stronger rThal to rIFG communication. Furthermore, control analyses did not reveal a similar key communication in a left lateralized model.

Conclusions
Together, these findings indicate a pivotal role of the rIFG as input and causal regulator of subcortical response inhibition nodes.
The Effect of Political Frictions on the Pricing and Supply of Insurance
Authors: Liu Jessica , Liu Weiling 
Published: September 2023

Abstract
Political frictions significantly affect both pricing and supply in the long-term care insurance (LTCI) market. Comparing the same insurer’s requests submitted for the same policy at the same time to different state regulators, we find that they are 13% more likely to be approved and receive 4% more of the requested amount after an election year. Over time, regulatory pushback on premium increase requests leads to persistently lower cash reserves and increases the probability of company dropout. An insurer who receives one-standard-deviation less of their requested increase is 20% more likely to leave the market next year.
Delta-8-tetrahydrocannabinol: a phytocannabinoid on the rise
Authors: Ledvina Kaitlin R , Suelzer Elizabeth , El-Alfy Abir T 
Published: September 2023

Abstract

Objective
Delta-8-tetrahydrocannabinol (THC) is a minor psychoactive phytocannabinoid, similar to delta-9-tetrahydrocannabinol. Recent statements released by the Food and Drug Administration and Center for Disease Control reported around 660 delta-8-THC exposure cases. With the rise in commercially available products, it is crucial to understand the pharmacological and toxicological properties of this compound. The objective of this review is to summarize current literature regarding the pharmacokinetic and pharmacologic properties of delta-8-THC.

Methodology
Searches were performed in MEDLINE (Ovid), Scopus, Web of Science Core Collection and Cochrane Central Register of Controlled Trials (CENTRAL). The searches used database-specific advanced search techniques.

Key findings
A total of 772 references were retrieved, with 517 references identified after the removal of duplicate articles. The references were imported into Rayyan (Rayyan.ai), and the retrieved articles (100) were reviewed and summarized. The scoping review is divided into sections focussing on the pharmacokinetic (12) and pharmacologic (88) properties of delta-8-THC. The majority of pharmacological studies examined the central nervous system effects of delta-8-THC. The findings suggest that it exhibits distinct pharmacological effects, and while its psychoactive profile may be milder compared to delta-9-THC, caution should still be exercised when considering its use. Pharmacologic effects often express a dose-dependent relationship with the potential for tolerance development.

Conclusions
In conclusion, this review provides a comprehensive examination of the current state of knowledge of delta-8-THC. Moreover, the review highlights several gaps in the existing literature, emphasizing the need for further research to fully elucidate the mechanisms of action, long-term effects and potential interactions with other drugs.
Bruton’s Tyrosine Kinase in Ankylosing Spondylitis
Authors: Liao Hsien-Tzung , Chen Chun-Hsiung 
Published: September 2023

Study Design.
Prospective case-control study.

Objective.
To explore the role of Bruton’s tyrosine kinase (BTK) in ankylosing spondylitis (AS).

Summary of Background Data.
AS substantially affects patients, impairing range of motion in the whole spine and peripheral joints, as well as overall quality of life. However, surveillance for this condition is limited and biomarkers that can predict disease activity are not well documented.

Methods.
The expression of the BTK gene in peripheral blood mononuclear cells was measured using flow cytometry and real time quantitative polymerase chain reaction (qPCR) in 36 AS patients and 30 healthy controls. Demographic features, Ankylosing Spondylitis Disease Activity Score (ASDAS)-CRP based, Bath Ankylosing Spondylitis Disease Activity Index, Bath Ankylosing Spondylitis Functional Index, HLA-B27, ESR, and CRP were evaluated to identify factors associated with BTK expression. Analyses were performed using Spearman’s rank correlation test for continuous data, the chi-test for categorical data, and that between continuous and dichotomous variables was measured using a point-biserial correlation test. The area under the curve (AUC) of the receiver operating characteristic (ROC) curve was used to assess the performance of each candidate biomarker.

Results.

BTK gene expression was significantly higher in AS patients than in controls (P=0.042) according to qPCR results. BTKY223 was also high in CD19+ peripheral blood mononuclear cells (PBMCs) from AS patients, with CD19+BTKY223+high cells being significantly positive correlated to ESR, CRP, and ASDAS. A negative association was observed between BTK expression and the chest expansion distance. The AUC for CD19+BTKY223+ was larger than that for ESR, but CRP still had the largest area.

Conclusions.
BTK expression was higher in PBMCs from AS patients when compared to controls, and was associated with a higher disease activity index, inflammatory reactants, arthritis and extra-articular manifestations. These findings suggest that BTK expression may play a crucial role in the inflammatory process in individuals with AS.
MRI-guided Real-time Online Gated Stereotactic Body Radiation Therapy for Liver Tumors
Authors: Prasad Venkatesulu Bhanu , Ness Emily , Ross Dylan , Saripalli Anjali L. , Abood Gerard , Badami Ami , Cotler Scott , Dhanarajan Asha , Knab Lawrence M. , Lee Brian , Molvar Christopher , Sethi Anil , Small Jr William , Refaat Tamer 
Published: September 2023

Background:
Liver tumors are commonly encountered in oncology. The study aimed to assess the impact of magnetic resonance imaging (MRI)-guided stereotactic body radiation therapy (SBRT) (MRgSBRT) on disease-related outcomes and the toxicity profile.

Methods:
Patients who received MRgSBRT from 2019 to 2021 for primary and metastatic liver tumors were included in this analysis. The protocol for treatment simulation included Gadoxetate disodium injection followed by a single-dimensional post-exhale MRI (0.35-T MRI linear accelerator) and computed tomography simulation. The patient demographics and treatment-related outcomes were assessed. The time-to-event curves were analyzed for freedom from local progression (FFLP) and overall survival (OS).

Results:
A total of 35 patients were eligible for analysis with a median age of 70 years (range 25 to 95). The median follow-up was 19.4 months (range 1 to 37 mo). The one-year OS was 77.7%, with an estimated 3 years of 47.9%. Patients with the locally controlled disease had a better median OS of 27.8 months (95% CI [23.8-31.6]) compared with 13.5 months (95% CI [5.6-21.3], P=0.007) in patients with local disease progression. The 1-year FFLP was 95.6%, and 3-year estimated FFLP was 87.1%. Patients who received a radiation dose of biologically equivalent dose≥100 Gy had FFLP of 30.9 months (95% CI [28.7-33.1]) compared with 13.3 months (95% CI [5.3-21.3], P=0.004) in patients who received <100 Gy biologically equivalent dose.

Conclusion:
MRI-guided SBRT provides optimal local control, associated with improved OS in a heavily morbid, pretreated older cohort of patients with reasonable safety profiles.