bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reversible Medical Image Watermarking for ROI-Based Tamper Detection and Recovery
Authors: Arham Aulia , Nugroho Hanung Adi , Adji Teguh Bharata 
Published: June 2023

Abstract

Medical image watermarking has become a widely studied topic in recent years. The method used to embed data into medical images must be reversible becouse tampered in medical images caused by irreversible embedding can lead to inaccurate diagnosis. Medical image watermark- ing should be able to identify the tampered area and recover it. This research work introduced a method for reversible watermarking of med- ical images. This method can embed data, detect any tampering that occurs, locate the area that has been tampered with, and then recov- ery that area of tampered in the medical image. The medical image is segmented into three sections. The first is the region of interest (ROI) for reversible embedding of patient records. The second is the region of non-interest (RONI) for reversible embedding of localization data for tampered and recovery areas. The third is the border area used for embedding coordinates of the selected ROI using Least Significant Bits (LSB). The proposed method has a capacity of up to 6 bpp of data and 12 % of the ROI area with very good visual quality of up to 50.86 dB. The watermarked image, when extracted, is identical from the original image except for the border area, provided that there is no tampering. If the ROI is tampered, the area of tampered can be identified and restored with results reaching up to +27.61 dB, with only a small difference in image quality -2.86 dB compared to the original image after extraction.
Kirschner Wire Prying and Leverage Technique—— A New Closed Reduction Method in the Treatment of Pediatric “Irreducible Supracondylar Humerus Fractures”
Authors: Yuan Xiao , Xin Liu , Ying Zhou , BO Ren , Jun Ye , Qiang Deng , Chi Kang 
Published: June 2023

Abstract
Objective This paper is aiming at introducing a new closed reduction method in the treatment of pediatric“Irreducible Supracondylar Humerus Fractures”.And making a clear definition of this type of fracture. Study design The sample of our study is the 120 cases of “Irreducible Supracondylar Humerus Fractures” treated surgically in our department. We classified them into two groups according to the methods being used in the treatment.Group 1 referred to the cases that were fixed by Closed reduction and percutaneous pinning(CRPP), while group 2 were treated by Kirschner wire prying and leverage technique combined with CRPP.Then we collected and evaluated relative data of two groups during the follow-up. Results The operative time and intraoperative fluoroscopy times of group 2 were significantly shorter than those of the group 1, and the percentage of open reduction in group 1 was significantly higher than that of group 2. Meanwhile, age, time from injury to surgery, and initial deviation of the distal fragment were the risk factors that leads to the failure of closed reduction. Conclusion We reached a conclusion that CRPP with kirschner wire prying and leverage technique is safe and effective in the treatment of “Irreducible Supracondylar Humerus Fractures”. This new method can significantly shorten the operation time, reduce the number of intraoperative fluoroscopy times, and lower the percentage of open reduction without increasing the risk of complications.
Recent Insights into Nanoparticulate Carrier Systems of Curcumin and its Clinical
Perspective in the Management of Various Health Issues
Authors: Harwansh Ranjit K. , Yadav Mukul , Deshmukh Rohitas , Rahman Akhlaquer 
Published: June 2023

Abstract:
Curcumin is a potent bioactive compound of Curcuma longa. Curcumin comprises a broad spectrum
of biological activities, including hepatoprotective, anticancer, antimicrobial, anti-inflammatory, antitumor, anti-
oxidant, etc. However, its low aqueous solubility, rapid excretion, and poor bioavailability restricted its therapeutic
uses. To resolve these issues, novel nano-systems have now been developed to increase the bioactivity
and bioavailability of curcumin by lowering the particle size, altering the surface, and increasing the efficacy of
its encapsulation with various nanocarriers. Nanotechnology-based treatments can broaden the outlook for individuals
with critical conditions. This article explores curcumin-based nanoparticulate carrier systems that
should be employed to overcome this natural ingredient's inherent limitations. These nanocarriers also provide
physical and chemical stability by encapsulating the drug into the core or matrix of the lipids or polymers. Nanotechnologists
developed curcumin-encapsulated various nanoparticulate systems, including solid lipidic nanoparticles,
polymeric nanoparticles, nano-structured lipid carriers, polymer conjugates, etc., to improve curcumin
bioavailability and boost the sustained release of curcumin to target cells.
Proteomic Analyses Reveal Functional Pathways and Potential Targets in
Pediatric Hydrocephalus
Authors: Ju Yiwen , Wan Zhenling , Zhang Qin , Li Si , Wang Bingshu , Qiu Jianmin , Zheng Shaojiang , Gu Shuo 
Published: June 2023

Introduction:
Hydrocephalus is a common pediatric disorder of cerebral spinal fluid physiology
resulting in abnormal expansion of the cerebral ventricles. However, the underlying molecular
mechanisms remain unknown.

Materials:
We performed proteomic analyses of cerebrospinal fluid (CSF) from 7 congenital hydrocephalus
and 5 arachnoid cyst patients who underwent surgical treatment. Differentially expressed
proteins (DEPs) were identified by label-free Mass Spectrometry followed by differential expression
analysis. The GO and GSEA enrichment analysis was performed to explore the cancer hallmark pathways
and immune-related pathways affected by DEPs. Then, network analysis was applied to reveal
the location of DEPs in the human protein-protein interactions (PPIs) network. Potential drugs for hydrocephalus
were identified based on drug-target interaction.

Results:
We identified 148 up-regulated proteins and 82 down-regulated proteins, which are potential
biomarkers for clinical diagnosis of hydrocephalus and arachnoid cyst. Functional enrichment analysis
revealed that the DEPs were significantly enriched in the cancer hallmark pathways and immunerelated
pathways. In addition, network analysis uncovered that DEPs were more likely to be located in
the central regions of the human PPIs network, suggesting DEPs may be proteins that play important
roles in human PPIs. Finally, we calculated the overlap of drug targets and the DEPs based on drugtarget
interaction to identify the potential therapeutic drugs of hydrocephalus.

Conclusion:
The comprehensive proteomic analyses provided valuable resources for investigating the molecular
pathways in hydrocephalus, and uncovered potential biomarkers for clinical diagnosis and therapy.
Implementation of PLGA-based Nanoparticles for Treatment of Colorectal Cancer
Authors: Gill Amandeep Kaur , Sharma Rajiv , Gautam Surya Prakash , Frank Amanda , Bajwa Neha , Singh Preet Amol 
Published: June 2023

:
Colorectal cancer is more prevalent in females than males. There are many anticancer drugs
accessible for use, but their therapeutic importance is constrained by factors including poor solubility, low
absorption, and multi-drug resistance. This review highlights how PLGA may be used to develop polymeric-
targeted drug delivery systems that specifically target colorectal cancer. The PLGA polymer, which
is disseminated in the colon together with drugs in a regulated and targeted manner, has the distinct characteristics
of smart degradation in a biological system. Its degradability is dependent on multiple glycolide
units; therefore, a lower glycol concentration improves degradability and vice versa. Also, PLGA
facilitates drug delivery in colorectal cancer, enhances the efficacy of the drug, improves the sustained
release profile of a drug, improves bioavailability due to prolonged retention time in the colon, enhances
solubility, etc. To develop the formulation for improving the cytotoxic impact of various anticancer drugs,
the surface modification of PLGA can be carried out by introducing a copolymer. By emphasizing their
crucial characterization to demonstrate their therapeutic potential, this literature work has also shed light
on recent patents and advancements in PLGA application.
Asymmetric Dimethylarginine (ADMA) in Cardiovascular Disease, Cardiac Ischemia/reperfusion Injury, and Ischemic Non-obstructive Coronary Artery Disease: Biochemical and Pharmacological Implications
Authors: Corradi Francesco , Bucciarelli Benedetta , Bianco Francesco , Bucciarelli Tonino 
Published: June 2023

:
Several studies have shown that high plasma concentrations of asymmetric dimethylarginine
(ADMA), a known endogenous competitive inhibitor of endothelial nitric oxide synthase (eNOS),
correlate with the severity of coronary artery disease (CAD), with worsening of cardiac
ischemia/reperfusion (I/R) injury and coronary atherosclerosis. It is believed that it may be an important
risk factor for myocardial infarction. ADMA, when in high concentrations, can determine a significant
decrease in the synthesis and bioavailability of NO (Nitric oxide) and therefore alter the mechanisms of
regulation of coronary vasodilation and vasomotor function of epicardial coronary arteries. Higher serum
ADMA concentration is associated with worsening of post-ischemic remodeling since coronary
angiogenesis, vasculogenesis, and collateral coronary growth are seriously impaired. In addition, there are
reasons to believe that elevated plasma ADMA levels are related to the development of diseases affecting
coronary microcirculation, such as ischemic non-obstructive coronary artery disease (INOCA). With the
aim of providing the pharmacologist engaged in the design and discovery of new ADMA-lowering drugs
with a complete examination of the subject, in this review, we discuss the most important studies related
to the correlations between serum ADMA levels and cardiovascular diseases mentioned above. In
addition, we critically discuss the main aspects of enzymology, synthesis, and metabolism of ADMA as a
prerequisite for understanding the molecular mechanisms through which high concentrations of ADMA
could contribute to promoting cardiovascular diseases. ADMA represents a new target for
pharmacological modulation of cardiovascular endothelial function and therefore, there is a possibility of
using selective pharmacological ADMA lowering drugs in cardiovascular disease with endothelial
dysfunction and high plasma ADMA levels.
Uncompetitive Inhibition of Polyol Pathway Enzymes by Daucus carota
Linn. Extract and Management of Diabetes Mellitus
Authors: Kazeem Mutiu Idowu , Bankole Habeeb Adebodun , Fatai Azeez Ayomide , Oguntubi Temitope Samson , Kappo Abidemi Paul 
Published: June 2023

Background:
The growing occurrence of complications associated with diabetes calls for the
unending exploration of natural products for more efficient therapeutic substances. The polyol pathway
is a foundational scheme involved in the development of diabetic complications. Retarding the activities
of enzymes in the polyol pathway is, therefore, a potent method of managing these complications.

Objective:
This work assessed the ability of four non-leafy vegetables, namely Daucus carota Linn.
(carrot), Abelmoschus esculentus (L.) Moench (okra), Allium cepa Linn. (onion), and Lycopersicon esculentum
Mill. (tomato), to inhibit the activities of aldose reductase and sorbitol dehydrogenase.

Methods:
The vegetables’ ability was evaluated by incubating the vegetables with suitable enzymes and
substrates. Sample(s) with the lowest inhibitory concentration (IC50) was utilized to determine the
mechanism of action of the enzymes by constructing the Lineweaver-Burk graph.

Results:
Results showed that the aqueous extract of carrot exhibited the lowest IC50 value for the inhibition
of both aldose reductase (135.17 μg/mL) and sorbitol dehydrogenase (14.64 μg/mL), respectively.
The double reciprocal plot also showed that the aqueous extract of carrot inhibited both aldose reductase
and sorbitol dehydrogenase in an uncompetitive fashion.

Conclusion:
Aqueous extract of carrot successfully retarded the action of polyol pathway enzymes,
which may result in the recovery of diabetic complications. This activity may due to the availability of
phytochemicals, including carotenoids and phenylacetylenes.
Emerging Nanotechnology-based Therapeutics: A New Insight into
Promising Drug Delivery System for Lung Cancer Therapy
Authors: Verma Ravinder , Rao Lakshita , Nagpal Diksha , Yadav Manish , Kumar Vivek , Kumar Vikram , Kumar Harish , Parashar Jatin , Bansal Nitin , Kumar Manish , Pandey Parijat , Mittal Vineet , Kaushik Deepak 
Published: June 2023

Background:
Lung cancer is a foremost global health issue due to its poor diagnosis. The
advancement of novel drug delivery systems and medical devices will aid its therapy.

Objective:
In this review, the authors thoroughly introduce the ideas and methods for improving nanomedicine-
based approaches for lung cancer therapy. This article provides mechanistic insight into various
novel drug delivery systems (DDSs) including nanoparticles, solid lipid nanoparticles, liposomes,
dendrimers, niosomes, and nanoemulsions for lung cancer therapy with recent research work. This review
provides insights into various patents published for lung cancer therapy based on nanomedicine.
This review also highlights the current status of approved and clinically tested nanoformulations for
their treatment.

Methodology:
For finding scholarly related data for the literature search, many search engines were
employed including PubMed, Science Direct, Google, Scihub, Google Scholar, Research Gate, Web of
Sciences, and several others. Various keywords and phrases were used for the search such as “nanoparticles”,
“solid lipid nanoparticles”, “liposomes”, “dendrimers”, “niosomes”, “nanoemulsions”, “lung
cancer”, “nanomedicine”, “nanomaterial”, “nanotechnology”, “in vivo” and “in vitro”. The most innovative
and cutting-edge nanotechnology-based approaches that are employed in pre-clinical and clinical
studies to address problems associated with lung cancer therapies are also mentioned in future prospects.
A variety of problems encountered with current lung cancer therapy techniques that frequently
led to inadequate therapeutic success are also discussed in the end.

Conclusion:
The development of nanoformulations at the pilot scale still faces some difficulties, but
their prospects for treating lung cancer appear to be promising in the future. Future developments and
trends are anticipated as the evaluation comes to a close.
Glycemic Control, Renal Progression, and Use of Telemedicine Phone Consultations Among Japanese Patients With Type 2 Diabetes Mellitus During the COVID-19 Pandemic: Retrospective Cohort Study
Authors: Sankoda Akiko , Nagae Yugo , Waki Kayo , Sze Wei Thing , Oba Koji , Mieno Makiko , Nangaku Masaomi , Yamauchi Toshimasa , Ohe Kazuhiko 
Published: June 2023

Background
Reduced or delayed medical follow-ups have been reported during the COVID-19 pandemic, which may lead to worsening clinical outcomes for patients with diabetes. The Japanese government granted special permission for medical institutions to use telephone consultations and other remote communication modes during the COVID-19 pandemic.

Objective
We aimed to evaluate changes in the frequency of outpatient consultations, glycemic control, and renal function among patients with type 2 diabetes before and during the COVID-19 pandemic.

Methods
This is a retrospective single-cohort study conducted in Tokyo, Japan, analyzing results for 3035 patients who visited the hospital regularly. We compared the frequency of outpatient consultations attended (both in person and via telemedicine phone consultation), glycated hemoglobin A1c (HbA1c), and estimated glomerular filtration rate (eGFR) among patients with type 2 diabetes mellitus during the 6 months from April 2020 to September 2020 (ie, during the COVID-19 pandemic) with those during the same period of the previous year, 2019, using Wilcoxon signed rank tests. We conducted a multivariate logistic regression analysis to identify factors related to the changes in glycemic control and eGFR. We also compared the changes in HbA1c and eGFR from 2019 to 2020 among telemedicine users and telemedicine nonusers using difference-in-differences design.

Results
The overall median number of outpatient consultations attended decreased significantly from 3 (IQR 2-3) in 2019 to 2 (IQR 2-3) in 2020 (P<.001). Median HbA1c levels deteriorated, though not to a clinically significant degree (6.90%, IQR 6.47%-7.39% vs 6.95%, IQR 6.47%-7.40%; P<.001). The decline in median eGFR was greater during the year 2019-2020 compared to the year 2018-2019 (–0.9 vs –0.5 mL/min/1.73 m2; P=.01). Changes in HbA1c and eGFR did not differ between patients who used telemedicine phone consultations and those who did not. Age and HbA1c level before the pandemic were positive predictors of worsening glycemic control during the COVID-19 pandemic, whereas the number of outpatient consultations attended was identified as a negative predictor of worsening glycemic control during the pandemic.

Conclusions
The COVID-19 pandemic resulted in reduced attendance of outpatient consultations among patients with type 2 diabetes, and these patients also experienced deterioration in kidney function. Difference in consultation modality (in person or by phone) did not affect glycemic control and renal progression of the patients.
Association of Socioeconomic Status With Long-Term Outcome in Survivors After Out-of-Hospital Cardiac Arrest: Nationwide Population-Based Longitudinal Study
Authors: Yoo Kyung Hun , Cho Yongil , Oh Jaehoon , Lee Juncheol , Ko Byuk Sung , Kang Hyunggoo , Lim Tae Ho , Lee Sang Hwan 
Published: June 2023

Background
Out-of-hospital cardiac arrest (OHCA) is a major public health problem and a leading cause of death worldwide. Previous studies have focused on improving the survival of people who have had OHCA by analyzing short-term survival outcomes, such as the return of spontaneous circulation, 30-day survival, and survival to discharge. Research has been conducted on prehospital prognostic factors to improve the survival of patients with OHCA, among which the association between socioeconomic status (SES) and survival has been reported. SES could affect bystander cardiopulmonary resuscitation rates and whether OHCA is witnessed, and low cardiopulmonary resuscitation education rates are associated with low SES. It has been reported that areas with high SES have shorter hospital transfer times and more public defibrillators per person. Previous studies have shown the impact of SES disparities on the short-term survival of patients with OHCA. However, understanding the impact of SES on the long-term prognosis of OHCA survivors remains limited. As long-term outcomes are more indicative of a patient’s ongoing health care needs and the burden on public health than short-term outcomes, understanding the long-term prognosis of OHCA survivors is important.

Objective
This study aimed to identify whether SES influenced the long-term outcomes of OHCA.

Methods
Using health claims data obtained from the National Health Insurance (NHI) service in Korea, we included OHCA survivors who were hospitalized between January 2005 and December 2015. The patients were divided into 2 groups: NHI and Medical Aid (MA) groups, with the MA group defined as having a low SES. Cumulative mortality was estimated using the Kaplan-Meier method, and a Cox proportional hazards model was used to evaluate the impact of SES on long-term mortality. A subgroup analysis was performed based on whether cardiac procedures were performed.

Results
We followed 4873 OHCA survivors for up to 14 years (median of 3.3 years). The Kaplan-Meier survival curve showed that the MA group had a significantly decreased long-term survival rate compared to the NHI group. With an adjusted hazard ratio (aHR) of 1.52 (95% CI 1.35-1.72), low SES was associated with increased long-term mortality. The overall mortality rate of the patients who underwent cardiac procedures in the MA group was significantly higher than that of the NHI group (aHR 1.72, 95% CI 1.05-2.82). The overall mortality rate of patients without cardiac procedures was also increased in the MA group compared to the NHI group (aHR 1.39, 95% CI 1.23-1.58).

Conclusions
OHCA survivors with low SES had an increased risk of poor long-term outcomes compared with those with higher SES. OHCA survivors with low SES who have undergone cardiac procedures need considerable care for long-term survival.
Hiện trạng và phân bố nguồn giống thủy sản ở vùng biển tỉnh Bến Tre
Authors: Từ Hoàng Nhân , Đào Thị Liên , Cao Văn Hùng 
Published: June 2023

Trong hai năm 2020-2021, số liệu về nguồn giống hải sản được thu thập ở vùng biển Bến Tre tại 30 trạm nghiên cứu đại diện cho hai mùa gió. Tổng số 240 mẫu bao gồm 120 mẫu trứng cá, cá con (TC-CC) và 120 mẫu ấu trùng tôm, tôm con (ATT-TC) đã được thu thập bằng lưới thu mẫu tầng mặt và thẳng đứng. Miệng lưới có gắn máy đo dòng chảy để xác định lượng nước qua lưới. Kết quả phân tích bước đầu cho thấy thành phần nguồn giống khá đa dạng với 30 loài và 41 họ cá; 13 loài và 13 họ tôm. Các họ cá chiếm ưu thế cả về số lượng và tần suất xuất hiện là họ cá trỏng, cá bống trắng, cá giả bống, cá đục và cá tuyết. Các họ tôm chiếm ưu thế là họ tôm he, tôm gai, tôm moi và tôm tít. Mật độ trung bình là 5.743 trứng cá và 299 cá con/1.000m3 nước biển ở tầng nước mặt, 1.296 trứng cá và 656 cá con/1.000 m3 nước biển ở tầng nước thẳng đứng. Mật độ ấu trùng và tôm con trung bình đạt 3.885 cá thể/1.000 m3 nước biển trong toàn vùng biển nghiên cứu. Khu vực từ cửa Tiểu tới cửa Cổ Chiên và lân cận được ghi nhận đóng vai trò rất quan trọng, là bãi sinh sản, bãi sinh trưởng tự nhiên của nhiều loài hải sản...
Nghiên cứu làm giàu và phân tích arsenic vô cơ (AsIII/AsV) trong nước bằng kĩ thuật chiết pha rắn sử dụng vật liệu ZIF-8 tổng hợp làm pha tĩnh
Authors: Phạm Quốc Yên , Trương Thị Tố Oanh 
Published: June 2023

Một phương pháp phân tích siêu vết arsenic vô cơ (iAs) trong nước được thực hiện thành công bằng phương pháp phổ khối plasma ghép cặp cảm ứng cao tần (ICP-MS) kết hợp kĩ thuật chiết pha rắn (SPE) sử dụng vật liệu ZIF-8 làm vật liệu hấp phụ cho quá trình làm giàu mẫu. Giới hạn phát hiện của phương pháp (LOD) cho kết quả 0,5 pg/mL với hệ số làm giàu 20 lần. ZIF-8 trong nghiên cứu này được tổng hợp bằng phương pháp nhiệt dung môi và đặc trưng cấu trúc vật liệu được kiểm tra bằng các phương pháp phân tích hiện đại bao gồm nhiễu xạ tia X (XRD), phổ hồng ngoại biến đổi fourier (FT-IR), kính hiển vi điện tử quét (SEM) và phương pháp Brunauer-Emmett-Teller (BET). Quá trình hấp phụ động qua cột SPE và giải hấp phụ bằng phương pháp lắc chiết được áp dụng cho quá trình làm giàu mẫu cho hiệu suất thu hồi của iAs trên 85%. Vật liệu ZIF-8 còn cho thấy khả năng thu hồi và tái sử dụng nhiều lần với hoạt tính và cấu trúc được duy trì tương đối ổn định.
Dự báo ngắn hạn sản lượng điện năng điện mặt trời mái nhà sử dụng mạng neuron nhân tạo
Authors: Nguyễn Phúc Khải , Trần Kim Long , Hà Phú Cường , Nguyễn Minh Huy , Hoàng Công Hưng 
Published: June 2023

Dự báo ngắn hạn sản lượng điện năng điện mặt trời mái nhà là công cụ thiết yếu trong quá trình vận hành hệ thống điện một cách hiệu quả. Bài báo này trình bày khảo sát về dự báo ngắn hạn sản lượng điện năng của một hệ thống điện năng lượng mặt trời sử dụng các mạng neuron nhân tạo. Dữ liệu được thu thập từ hệ thống giám sát với công suất điện và bức xạ mặt trời từ ngày 21/04/2022 đến 01/6/2022. Bốn mô hình mạng neuron được sử dụng để dự báo điện năng gồm: mạng neuron lan truyền thẳng nhiều lớp (MLFF), mô hình neuron tự hồi quy phi tuyến tính với đa biến ngoại sinh (NARX), mô hình neuron bộ nhớ dài-ngắn hạn (LSTM) và mô hình kết hợp NARX-LSTM. Các phương pháp đề xuất để kiểm tra hiệu quả cho các bài toán dự báo 5 phút và 1 giờ. Kết quả cho thấy mô hình mạng neuron truyền thẳng nhiều lớp cho kết quả dự báo chính xác hơn so với các phương pháp khác trong cả 2 trường hợp tính toán.