bluuebunny/crossref_metadata_2025_split huggingface dataset:
Health and Economic Impacts of Implementing Produce Prescription Programs for Diabetes in the United States: A Microsimulation Study
Authors: Wang Lu , Lauren Brianna N. , Hager Kurt , Zhang Fang Fang , Wong John B. , Kim David D. , Mozaffarian Dariush 
Published: July 2023

Background
Produce prescription programs, providing free or discounted produce and nutrition education to patients with diet‐related conditions within health care systems, have been shown to improve dietary quality and cardiometabolic risk factors. The potential impact of implementing produce prescription programs for patients with diabetes on long‐term health gains, costs, and cost‐effectiveness in the United States has not been established.

Methods and Results
We used a validated state‐transition microsimulation model (Diabetes, Obesity, Cardiovascular Disease Microsimulation model), populated with national data of eligible individuals from the National Health and Nutrition Examination Survey 2013 to 2018, further incorporating estimated intervention effects and diet‐disease effects from meta‐analyses, and policy‐ and health‐related costs from published literature. The model estimated that over a lifetime (mean=25 years), implementing produce prescriptions in 6.5 million US adults with both diabetes and food insecurity (lifetime treatment) would prevent 292 000 (95% uncertainty interval, 143 000–440 000) cardiovascular disease events, generate 260 000 (110000–411 000) quality‐adjusted life‐years, cost $44.3 billion in implementation costs, and save $39.6 billion ($20.5–58.6 billion) in health care costs and $4.8 billion ($1.84–$7.70 billion) in productivity costs. The program was highly cost effective from a health care perspective (incremental cost‐effectiveness ratio: $18 100/quality‐adjusted life‐years) and cost saving from a societal perspective (net savings: $−0.05 billion). The intervention remained cost effective at shorter time horizons of 5 and 10 years. Results were similar in population subgroups by age, race or ethnicity, education, and baseline insurance status.

Conclusions
Our model suggests that implementing produce prescriptions among US adults with diabetes and food insecurity would generate substantial health gains and be highly cost effective.
Number of Passes of Endovascular Therapy for Stroke With a Large Ischemic Core: Secondary Analysis of RESCUE-Japan LIMIT
Authors: Namitome Satoshi , Uchida Kazutaka , Shindo Seigo , Yoshimura Shinichi , Sakai Nobuyuki , Yamagami Hiroshi , Toyoda Kazunori , Matsumaru Yuji , Matsumoto Yasushi , Kimura Kazumi , Ishikura Reiichi , Inoue Manabu , Beppu Mikiya , Sakakibara Fumihiro , Shirakawa Manabu , Ueda Mitsuharu , Morimoto Takeshi ,   for the RESCUE-Japan LIMIT Investigators
Published: July 2023

BACKGROUND:
The increased risk of intracranial hemorrhage with multiple passes in endovascular therapy (EVT) for large vessel occlusion with a large ischemic core is a concern. We explored the effect of the number of EVT passes on patients in a randomized clinical trial.

METHODS:
This post hoc study was the secondary analysis of RESCUE-Japan LIMIT, which was a randomized clinical trial comparing EVT and medical treatment alone for large vessel occlusion with large ischemic core. We grouped patients according to the number of passes with successful reperfusion (modified Thrombolysis in Cerebral Infarction score, ≥2b) in 1, 2, and 3 to 7 passes and failed reperfusion (modified Thrombolysis in Cerebral Infarction score, 0–2a) after any pass in the EVT group, and these groups were compared with medical treatment group. The primary outcome was modified Rankin Scale score of 0 to 3 at 90 days. Secondary outcomes were improvement in National Institutes of Health Stroke Scale score of ≥8 at 48 hours, mortality at 90 days, symptomatic intracranial hemorrhage, and any intracranial hemorrhage within 48 hours.

RESULTS:
The number of patients who received EVT with successful reperfusion after 1, 2, and 3 to 7 passes and failed reperfusion were 44, 23, 19, and 14, respectively, and 102 received medical treatment alone. The adjusted odds ratios (95% CIs) for the primary outcome relative to medical treatment were 5.52 (2.23–14.28) after 1 pass, 6.45 (2.22–19.30) after 2 passes, 1.03 (0.15–4.48) after 3 to 7 passes, and 1.17 (0.16–5.37) if reperfusion failed. The adjusted odds ratios (95% CIs) for any intracranial hemorrhage within 48 hours relative to medical treatment were 1.88 (0.90–3.93) after 1 pass, 5.14 (1.97–14.72) after 2 passes, 3.00 (1.09–8.58) after 3 to 7 passes, and 6.16 (1.87–24.27) if reperfusion failed.

CONCLUSIONS:
The successful reperfusion within 2 passes was associated with better clinical outcomes.

REGISTRATION:

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT03702413.
Collaborators of Justice: Consensual Procedural Forms Serving Probative Purposes Analysed Through Practitioners’ Experiences in Croatia
Authors: Ivičević Karas Elizabeta , Buric Zoran , Pajčić Matko 
Published: July 2023

Abstract
This paper presents the research results of Croatian practitioners’ experiences in applying consensual forms which serve probative purposes. The aim of the research was to find out, through the qualitative analysis of practical experiences obtained through semi-structured interviews with 60 practitioners in criminal justice system – 20 judges, 20 state attorneys and 20 defence attorneys, and then through discussions in four focus groups, how measures of rewarding collaborators of justice are applied in practice. The focus was on procedural tools which may be used to ensure respect of the principle of legality and the lawful application of the principle of discretionary prosecution, as well as on judicial control, which should efficiently prevent “mixing the procedural roles” of the accused and the witness. Particular attention was paid to the emergence of informal agreements, which puts into question the whole concept of regulated consensual forms serving probative purposes. An analysis of the practical experiences of different stakeholders reveals the existing deficiencies of normative regulation and applied practices.
The Global Wind Atlas: A High-Resolution Dataset of Climatologies and Associated Web-Based Application
Authors: Davis Neil N. , Badger Jake , Hahmann Andrea N. , Hansen Brian O. , Mortensen Niels G. , Kelly Mark , Larsén Xiaoli G. , Olsen Bjarke T. , Floors Rogier , Lizcano Gil , Casso Pau , Lacave Oriol , Bosch Albert , Bauwens Ides , Knight Oliver James , Potter van Loon Albertine , Fox Rachel , Parvanyan Tigran , Krohn Hansen Søren Bo , Heathfield Duncan , Onninen Marko , Drummond Ray 
Published: July 2023

Abstract
The Global Wind Atlas (GWA) provides high-resolution databases and maps of the wind resource for all land points and for water points within 200 km of the coastline, excluding Antarctica. The GWA is used to identify and understand the global, national, regional, and local potential for wind energy and to guide energy specialists, policymakers, and planners in the transition to a sustainable energy system. This information is vital to ensuring the growth of wind energy, helping to transition to a sustainable energy system, which will mitigate climate change and meet the world’s need for reliable, affordable, and clean energy. The GWA uses the established numerical wind atlas methodology to downscale coarse-resolution wind data to microscale, using linearized flow modeling and high-resolution topographic data. There have been three versions of the GWA, each using mesoscale model data at successively higher spatial resolution. A website and geographic information system (GIS) files support quick and in-depth analysis. Validation data and analysis, using measurements from tall masts located worldwide, are also provided through the web application. The development process of the GWA involves a dialogue between meteorological modelers, wind energy development experts, web designers, and representatives of the end users to provide accurate data in a dynamic and relevant way. This article outlines the general method, specific development, and application of the Global Wind Atlas.
A retrospective observational study of real-time ultrasound-guided peripheral arterial cannulation in infants
Authors: Corder William , Stoller Jason Z , Fraga María V 
Published: July 2023

Objective: To examine first attempt success and overall success of real-time ultrasound guided peripheral arterial cannulation in infants. Study design: Retrospective review of 477 ultrasound guided peripheral arterial cannulations in infants less than 1 year of age. Procedural and patient characteristics were evaluated to better understand factors related to procedural success. Results: Ultrasound guided peripheral arterial cannulation had a first attempt success rate of 65% and an overall success rate of 86%. Success rates significantly differed by arterial location ( p < 0.001). First attempt success and overall success were highest in the radial artery (72%, 91%) and lowest in the posterior tibial artery (44%, 71%). Success was more likely with greater age and greater weight ( p = 0.006, p = 0.002). Conclusion: Success rates are high when using a real-time ultrasound-guided technique for peripheral arterial cannulation in infants. An infant’s weight and selected artery are strong predictors of success when performing peripheral arterial cannulation. The use of procedural ultrasound may reduce unnecessary attempts and minimize procedure-related harm.
Bone marrow sinusoidal endothelial cells are a site of Fgf23 upregulation in a mouse model of iron deficiency anemia
Authors: Li Xiuqi , Lozovatsky Larisa , Tommasini Steven M. , Fretz Jackie , Finberg Karin E. 
Published: July 2023

Abstract
Iron deficiency is a potent stimulator of fibroblast growth factor 23 (FGF23), a hormonal regulator of phosphate and vitamin D metabolism, that is classically thought to be produced by bone-embedded osteocytes. Here, we show that iron-deficient transmembrane serine protease 6 knockout (Tmprss6–/–) mice exhibit elevated circulating FGF23 and Fgf23 messenger RNA (mRNA) upregulation in the bone marrow (BM) but not the cortical bone. To clarify sites of Fgf23 promoter activity in Tmprss6–/– mice, we introduced a heterozygous enhanced green fluorescent protein (eGFP) reporter allele at the endogenous Fgf23 locus. Heterozygous Fgf23 disruption did not alter the severity of systemic iron deficiency or anemia in the Tmprss6–/– mice. Tmprss6–/–Fgf23+/eGFP mice showed green fluorescence in the vascular regions of BM sections and showed a subset of BM endothelial cells that were GFPbright by flow cytometry. Mining of transcriptomic data sets from mice with normal iron balance revealed higher Fgf23 mRNA in BM sinusoidal endothelial cells (BM-SECs) than that in other BM endothelial cell populations. Anti-GFP immunohistochemistry of fixed BM sections from Tmprss6–/–Fgf23+/eGFP mice revealed GFP expression in BM-SECs, which was more intense than in nonanemic controls. In addition, in mice with intact Tmprss6 alleles, Fgf23-eGFP reporter expression increased in BM-SECs following large-volume phlebotomy and also following erythropoietin treatment both ex vivo and in vivo. Collectively, our results identified BM-SECs as a novel site for Fgf23 upregulation in both acute and chronic anemia. Given the elevated serum erythropoietin in both anemic models, our findings raise the possibility that erythropoietin may act directly on BM-SECs to promote FGF23 production during anemia.
Epstein–Barr virus-associated B-cell lymphoproliferative disorder meeting the definition of CAEBV B cell disease: a case report
Authors: Ma Yaxian , Bao Yuhan , Zheng Miao 
Published: July 2023

Abstract
Background
Chronic active Epstein-Barr virus infection (CAEBV) is a systemic EBV-positive lymphoproliferative disorder (EBV-LPD) considered to be associated with a genetic immunological abnormality, although its cause is still unclear. EBV is usually detected in T cells or NK cells in CAEBV patients with only a few cases involving B cells described in East Asia, which may be due to differences in genetic and environmental factors.

Case description
A 16-year-old boy who seemed to be diagnosed as CAEBV of B cell type was studied. The patient had IM-like symptoms persisting for more than 3 months, high levels of EBV DNA in the PB, and positive EBER in situ hybridization in B cells. In addition, to exclude underlying genetic disorders, we performed next-generation sequencing (NGS) and whole-exome sequencing (WES), which identified the missense mutation in PIK3CD (E1021K), ADA (S85L) and CD3D (Q140K) in the patient while no same genetic mutation was detected in his parents and sister. However, there is no diagnosis of CAEBV of B cell type in the most recent World Health Organization classification of tumors of hematopoietic and lymphoid tissues, therefore we finally diagnosed this patient as EBV-B-LPD.

Conclusions
This study shows a rare case of a patient meeting the definition of CAEBV B-cell disease in East Asia. Meanwhile, the case indicates that the missense mutation and the disease are related.
The use of mass media by mothers and its association with their children’s early development: comparison between urban and rural areas
Authors: Islam M Mofizul 
Published: July 2023

Abstract
Background
Mass media can play critical roles in influencing parents’ attitudes and practice toward the healthy upbringing of children.

Objective
This study examined the association between the use of five types of mass media among mothers living in rural and urban areas and the early childhood development (ECD) of their children.

Methods
We analysed nationally representative and internationally standardized Multiple Indicator Cluster Survey data collected in 2013 and 2019 in Bangladesh. The ECD was calculated using four domains of development: physical health, literacy-numeracy, learning and social-emotional. Mothers’ use of newspapers/magazines, radio, television, internet and mobile phones was the study factor. We used Poisson regression with robust variance. The dataset included 27,091 children aged three or four years.

Results
Almost 21% of the children were living in urban and 78% in rural areas. Mothers/caretakers of 30% of the children used none, 39% used one, 25% used two, and approximately 6% used three or more of the five types of media. Mobile phones and television were the dominant types of media, both in terms of the number of users and the frequency of use. Overall, 68.87% of the children were on track in terms of their ECD and 31.13% were not. A significantly larger proportion of urban children (74.23%) than rural children (67.47%) were on track in their ECD. The prevalence of children being on track of ECD increases by 4% (aPR 1.04; 95%CI: 1.01–1.06) for each additional media use among women who lived in urban areas and increases by 7% if women live in rural areas. In terms of the individual formats of media, using newspapers, television and internet was found to be significantly associated with the children in rural areas being on track in terms of their ECD. In the urban sample, only radio use was found to be significant.

Conclusions
Targeted and well-designed child development campaigns that are delivered through popular media types are likely to help mothers to take better care of their children.
Cleaner outdoor air diminishes the overall risk of intracerebral hemorrhage but brings differential benefits to subpopulations: a time-stratified case-crossover study
Authors: Wang Peng , Feng Wentao , Luo Shuang , Cheng Shuwen , Gong Min , Li Yaxin , Liu Yanhui 
Published: July 2023

Abstract
Background
Short-term air pollution exposure and intracerebral hemorrhage (ICH) risk are related. However, the impact of the pollutant levels decline on this relationship, which attributes to clean air policy implementation and the COVID-19 pandemic lockdown, is unclear. In the present research, we explored the influence of different pollutant levels on ICH risk during eight years in a southwestern China megacity.

Methods
Our research used a time-stratified case-crossover design. We retrospectively analyzed ICH patients in a teaching hospital from January 1, 2014, to December 31, 2021, and divided 1571 eligible cases into two groups (1st group: 2014–2017; 2nd group: 2018–2021). We observed the trend of every pollutant in the entire study period and compared the pollution levels in each group, using air pollutants data (PM2.5, PM10, SO2, NO2, CO, and O3) documented by the local government. We further established a single pollutant model via conditional logistic regression to analyze the association between short-term air pollutants exposure and ICH risk. We also discussed the association of pollution levels and ICH risk in subpopulations according to individual factors and monthly mean temperature.

Results
We found that five air pollutants (PM2.5, PM10, SO2, NO2, CO) exhibited a continuous downward trend for the whole duration, and the daily concentration of all six pollutants decreased significantly in 2018–2021 compared with 2014–2017. Overall, the elevation of daily PM2.5, SO2, and CO was associated with increased ICH risk in the first group and was not positively associated with risk escalation in the second group. For patients in subgroups, the changes in the influence of lower pollutant levels on ICH risk were diverse. In the second group, for instance, PM2.5 and PM10 were associated with lower ICH risk in non-hypertension, smoking, and alcohol-drinking participants; however, SO2 had associations with increased ICH risk for smokers, and O3 had associations with raised risk in men, non-drinking, warm month population.

Conclusions
Our study suggests that decreased pollution levels diminish the adverse effects of short-term air pollutants exposure and ICH risk in general. Nevertheless, the influence of lower air pollutants on ICH risk in subgroups is heterogeneous, indicating unequal benefits among subpopulations.
Acupuncture on GB34 for immediate analgesia and regulating pain-related anxiety for patients with biliary colic: a protocol of randomized controlled trial
Authors: Zhou YuanFang , Shen YuQuan , Ye XiangYin , He DongMei , Sun Ning , Zhang Yong , Zhang YaFei , Long Chao , Ding ShanBin , Deng LiPing , Deng Yi , Liang FanRong , Gong XianTian , Sun RuiRui 
Published: July 2023

Abstract
Background
Biliary colic (BC) is a frequent hepatobiliary disorder encountered in emergency departments. Acupuncture may be effective as an alternative and complementary medicine for BC. Nonetheless, rigorous trials investigating its efficacy are lacking. Therefore, the aim of this study protocol is to determine whether acupuncture provides immediate relief of pain and associated symptoms in BC patients.

Method
Eighty-six participants who aged from 18 to 60 years with BC will be recruited in the First People's Hospital of Longquanyi District, Chengdu (West China Longquan Hospital Sichuan University). All participants will be allocated into two treatment groups including acupuncture group and sham acupuncture group using a 1:1 ratio. Each group will only receive a single 30-min needle treatment while waiting for their test results after completing the routine examination for BC. The primary outcome of the study is to assess the change in pain intensity after the 30-min acupuncture treatment. The secondary outcomes of the study include the change in pain intensity at various time points, the degree of gastrointestinal symptoms at different time points, the level of anxiety experienced during pain episodes at different time points, the score of Pain Anxiety Symptoms Scale-20 (PASS-20), the score of Fear of Pain Questionnaire-III (FPQ-III), and the score of Pain Catastrophizing Scale (PCS), among others.

Discussion
The results of this research will provide substantial evidence regarding the efficacy of acupuncture in alleviating symptoms associated with BC.

Trial registration
ClinicalTrials.gov, ChiCTR2300070661. Registered on 19 April 2023.
Persistent descending mesocolon as a vital risk factor for anastomotic failure and prolonged operative time for sigmoid colon and rectal cancers
Authors: Mei Shiwen , Zhang Mingguang , Ye Feng , Qiu Wenlong , Quan Jichuan , Zhuang Meng , Wang Xishan , Tang Jianqiang 
Published: July 2023

Abstract
Background
The diagnostic criteria and effect of persistent descending mesocolon (PDM) on sigmoid and rectal cancers (SRCs) remain controversial. This study aims to clarify PDM patients' radiological features and short-term surgical results.

Method
From January 2020 to December 2021, radiological imaging data from 845 consecutive patients were retrospectively analyzed using multiplanar reconstruction (MRP) and maximum intensity projection (MIP). PDM is defined as the condition wherein the right margin of the descending colon is located medially to the left renal hilum. Propensity score matching (PSM) was used to minimize database bias. The anatomical features and surgical results of PDM patients were compared with those of non-PDM patients.

Results
Thirty-two patients with PDM and 813 patients with non-PDM were enrolled into the study who underwent laparoscopic resection. After 1:4 matching, patients were stratified into PDM (n = 27) and non-PDM (n = 105) groups. The lengths from the inferior mesenteric artery (IMA) to the inferior mesenteric vein (1.6 cm vs. 2.5 cm, p = 0.001), IMA to marginal artery arch (2.7 cm vs. 8.4 cm, p = 0.001), and IMA to the colon (3.3 cm vs. 10.2 cm, p = 0.001) were significantly shorter in the PDM group than those in the non-PDM group. The conversion to open surgery (11.1% vs. 0.9%, p = 0.008), operative time (210 min vs. 163 min, p = 0.001), intraoperative blood loss (50 ml vs. 30 ml, p = 0.002), marginal arch injury (14.8% vs. 0.9%, p = 0.006), splenic flexure free (22.2% vs. 3.8%, p = 0.005), Hartmann procedure (18.5% vs. 0.0%, p < 0.001) and anastomosis failure (18.5% vs. 0.9%, p = 0.001) were significantly higher in the PDM group. Moreover, PDM was an independent risk factor for prolonged operative time (OR = 3.205, p = 0.004) and anastomotic failure (OR = 7.601, p = 0.003).

Conclusion
PDM was an independent risk factor for prolonged operative time and anastomotic failure in SRCs surgery. Preoperative radiological evaluation using MRP and MIP can help surgeons better handle this rare congenital variant.