bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cell-Penetrating Peptides: A Powerful Tool for Targeted Drug Delivery
Authors: Kotadiya Dushyant D. , Patel Piyushkumar , Patel Hitesh D. 
Published: April 2023

Abstract:
The cellular membrane hinders the effective delivery of therapeutics to targeted sites. Cellpenetrating
peptide (CPP) is one of the best options for rapidly internalizing across the cellular membrane.
CPPs have recently attracted lots of attention because of their excellent transduction efficiency
and low cytotoxicity. The CPP-cargo complex is an effective and efficient method of delivering several
chemotherapeutic agents used to treat various diseases. Additionally, CPP has become another strategy
to overcome some of the current therapeutic agents' limitations. However, no CPP complex is approved
by the US FDA because of its limitations and issues. In this review, we mainly discuss the cellpenetrating
peptide as the delivery vehicle, the cellular uptake mechanism of CPPs, their design, and
some strategies to synthesize the CPP complex via some linkers such as disulfide bond, oxime, etc.
Here, we also discuss the recent status of CPPs in the market.
An Insight into the Role of Biodegradable Controlled-release Polymers and
Nanoformulations for Enhanced Brain Drug Delivery
Authors: Joshi Deepika 
Published: April 2023

Abstract:
Neurological or brain disorders are increasingly recognized as major causes of death and disability
worldwide, eventually leading to the burden of non-communicable and communicable diseases in
the world. Biodegradable functions of polymers provide promising solutions to meet the therapeutic needs
of neurological disorders owing to advantages such as the usage of biodegradable polymers in drug delivery
approaches, which has become noticeable due to their biocompatibility and degradability properties.
Due to such properties, they are degraded inside the body to produce natural/ nontoxic byproducts such as
water and carbon dioxide and hence eliminated easily. Sustained drug delivery by biodegradable polymer
devices can increase the therapeutic efficacy of drugs by producing high local tissue concentrations over
extended periods of time. This review discusses recent progress in the research and development of biodegradable
polymers, including their nanoformulation approaches.
Prevalence, Incidence and Factors Associated with Diabetic Foot in People
with Type 2 Diabetes: Systematic Review with Meta-Analysis
Authors: de Jesus Nascimento de Aquino Maria , de Souza Ana Célia Caetano , Borges José Wicto Pereira , da Silva Negreiros Francisca Diana , de Sousa Gonçalves Marilia , Martins Polyanna Maria Oliveira , Moreira Thereza Maria Magalhães 
Published: April 2023

Background:
Diabetic Foot is a severe chronic complication of diabetes and an important
factor in the morbidity of diabetic people, resulting in high health costs and increased risk
of death.

Objective:
To analyze the incidence, prevalence, and risk factors associated with diabetic foot in
people with type 2 Diabetes Mellitus.

Method:
Systematic literature review. Searches in MedLine via PubMed, LILACS, Web of Science,
Scopus CINAHL, and Cochrane Library databases were performed. Inclusion of 52 studies.
The R program, Metan packages, was used to calculate the meta-analysis. Given the heterogeneity
of studies, the random effect was used to calculate the meta-analysis of risk factors.

Results:
The meta-analysis showed that the prevalence of diabetic foot was 14% in a hospital setting
and 5% in a community setting. The overall prevalence and incidence were 9% and 4%, respectively.
Significant risk factors included time of DM (odds ratio [OR] =1.46, confidence interval
[CI], 0.36-2.57, P = 0.009), smoking (OR = 1.46, CI, 1.16 -1.85, P< .001), glycated hemoglobin
(OR = 0.96, CI, 0.50; 1.42, P< .001), peripheral arterial disease (OR = 3.38, CI, 2.07; 5.53, P <
.001) and peripheral neuropathy (OR = 5.88, CI, 2.39-14.45, P<.001).

Conclusion:
Multidisciplinary monitoring, educational strategies, periodic foot examination for alterations,
and early identification of risk factors are essential to prevent ulceration and reduce the
disease burden.
The Predictive Factors of Postpartum Women's Quality of Life: A Cross-
Sectional Study in Shiraz, Iran
Authors: Kaveh Mohammad Hossein , Khademi Khadijeh , Ghahremani Leila , Karimi Masoud , Nazari Mahin 
Published: April 2023

Background:
The postpartum period is a challenging time for mothers, in which the quality
of life (QOL) is an important indicator of health. Assessing the factors related to postpartum QOL
(PQOL) can provide a holistic approach to health programs from an individual to a macro level. This
study identified predictive factors for PQOL among Iranian postpartum women.

Methods:
This cross-sectional study was conducted using demographic, obstetric, and PQOL questionnaires
on 236 postpartum women. The data were subsequently analyzed using descriptive and analytical
statistics.

Results:
The results identified education level, delivery method (p< 0.05), planned pregnancy, and
sufficient family income (p< 0.001) as the four factors associated with PQOL. In addition, adequate
family income was identified as a predictor of PQOL (p< 0.001).

Conclusion:
Given that mothers' health helps to ensure the health of their families and communities,
they should be classified according to PQOL predictors and matched with appropriate health programs
to provide a high-quality postpartum period.
3-Bromopyruvate Inhibits the Growth and Glucose Metabolism of TNBC Xenografts
in Nude Mice by Targeting c-Myc
Authors: Pan Jian-Min , Li Jia-Chen , Yang Cheng , Xiao Wang-Fa , Li Qi-Shang , Luo Xiao-Hui , Zhang Xiao-Dong 
Published: April 2023

Background:
Due to the lack of effective drug treatment, triple-negative breast cancer (TNBC) is prone to
recurrence and metastasis after an operation. As a glycolytic inhibitor, 3-bromopyruvic acid (3-BrPA) can inhibit the
proliferation and induce apoptosis of TNBC cells. However, whether it has similar effects in animal models remains
unclear.

Objective:
To observe the effect of 3-BrPA on the growth and glucose metabolism of human TNBC transplanted tumors
in nude mice and to investigate the mechanism.

Methods:
We constructed subcutaneous xenografts of human TNBC in nude mice and treated them with low, medium
and high concentrations of 3-BrPA. After 15 days, nude mice were sacrificed to detect hexokinase (HK) activity and
adenosine triphosphate (ATP) content in tumor tissues. Hematoxylin-eosin (HE) staining was used to detect the damage
of transplanted tumors and liver and kidney in nude mice, which 3-BrPA caused. The expression of c-Myc in tumor
tissues was detected by Immunohistochemistry (IHC). Terminal deoxynucleotidyl transferase-mediated dUTP
nick-end labeling (TUNEL) staining was used to detect the apoptosis of tumor tissues. Besides, the expressions of Cytc,
Bax, Bcl-2 and Caspase-9 were detected by Western blotting.

Results:
Compared with the control group, intraperitoneal injection of 3-BrPA inhibited the growth of human TNBC
transplant tumors, decreased HK activity and ATP production in tumor tissues, disrupted the tissue structure of transplant
tumors, and did not significantly damage liver and kidney tissues. IHC staining and Western blotting showed that
3-BrPA could decrease the expression of c-Myc and Bcl-2, increase the expression of Cyt -c, Bax and Caspase-9 expression
and promote apoptosis in tumor tissues.

Conclusion:
The above data indicate that 3-BrPA inhibits the growth of human TNBC transplanted tumors and promotes
their apoptosis. Its anti-cancer mechanism might reduce HK activity by down-regulating c-Myc expression,
eventually leading to decreased glycolytic pathway energy production and promoting apoptosis of transplanted tumors.
L-Tartaric Acid Inhibits Diminazene-induced Vasorelaxation in Isolated
Rat Aorta
Authors: Amssayef Ayoub , Bouadid Ismail , Eddouks Mohamed 
Published: April 2023

Aims:
The study investigated the effect of L-tartaric acid on diminazene-indiuced vasorelaxation.

Background:
Diminazene is known to induce vasorelaxation through the stimulation of angiotensin-
converting enzyme (ACE-2).

Objective:
This work was designed to study the effect of L-tartaric acid on diminazene-induced
vasorelaxation using an ex vivo approach.

Material and Methods:
In the current investigation, the inhibitory effect of L-tartaric acid on
diminazene-induced relaxation.

Results:
The results confirmed that L-tartaric acid was able to inhibit in a dose-dependent manner
diminazene-induced vasorelaxation.

Conclusion:
This investigation provides important experimental evidence of the efficacy of Ltartaric
acid in inhibiting diminazene-induced vasorelaxation.
Validation of Inhibitory Activity of Thiazolidine-4-carboxylic Acid
Derivatives against Novel Influenza Neuraminidase Enzyme
Authors: Jain Namrata , K. Anita , Yadav Aakanksha 
Published: April 2023

Background:
Neuraminidase enzymes are a large family found in a range of organisms.
The best-known neuraminidase is viral neuraminidase, a drug target for the prevention of the spread of
influenza infection. The viral neuraminidases are frequently used as antigenic determinants found on
the surface of the influenza virus.

Objective:
Thiazolidine derivatives have been synthesized and explored previously, and further compounds
have been designed on the basis of leading compounds. This research aimed to validate those
previously synthesized compounds and a new series of compounds.

Methods:
A series of 28 compounds of thiazolidine-4-carboxylic acid derivatives were studied and
evaluated for their ability to inhibit the neuraminidase (NA) of the influenza A virus. Twenty-eight
compounds were differentiated into a training set of 21 compounds and a test set of 07 compounds.

Results:
The validated compounds demonstrated moderate inhibitory activity against influenza A neuraminidase.
The most potent compound was acetaminophen mercapturate (C13H16N2O5S) (MW:
312.34). S-(5-acetamido-2-hydroxyphenyl)-N-acetyl-L-cysteine is an S-substituted N-acetyl-Lcysteine
in which the S-substituent is specified as 5-acetamido-2-hydroxyphenyl. It acts as a drug metabolite,
a human urinary metabolite, and a rat metabolite. It is a member of acetamides, an organic
sulphide, a member of phenols and an S-substituted N-acetyl-L-cysteine. It derives
from “paracetamol”.

Conclusion:
Validation of inhibitory activity of thiazolidine-4-carboxylic acid derivatives as novel influenza
NA shows drug discovery of a more potent and reliable drug for the influenza virus.
Investigation of the effect of hydrogen enrichment on the performance, emission, and combustion characteristics of a diesel engine
Authors: Vasanthakumar R. , Loganathan M. , Chockalingam S. , Vikneswaran M. , Venkatramanan S. 
Published: April 2023

Abstract:
With an aim to partially replace conventional diesel fuel, this work investigated the impact of injecting hydrogen into an intake manifold of a diesel engine on its performance. Due to the benefits of hydrogen fuel, such as its high calorific value and flame velocity, it can be used in a dual-fuel mode of operation with diesel. The experiment was carried out for various engine loads with engine speed maintained constant at 1500. By using a digital volume flow metre, hydrogen was injected at three different volume flow rates, namely 3, 6, and 9 lpm. Engine combustion, emission, and performance parameters were evaluated for different hydrogen flow rates and compared to sole diesel. The result revealed that the brake thermal efficiency of the engine increased, whereas the brake-specific fuel consumption decreased due to hydrogen enrichment. The hydrocarbon and carbon monoxide emissions were lower in dual fuel mode when compared to sole diesel operation under all load situations. On the other hand, Oxides of Nitrogen (NOx) emission increased with hydrogen flow rate and resulted in higher NOx than diesel. Furthermore, hydrogen enrichment increased the values of the peak heat release rate and cylinder pressure by a significant margin from the corresponding values given by diesel fuel. Among the evaluated H2 flow rates, 9 lpm is found to be the best, demonstrating enhanced engine characteristics

background:
Due to the benefits of hydrogen fuel, such as its high calorific value and flame velocity, it can be used in a dual fuel mode of operation with diesel. The experiment was carried out for various engine loads with engine speed maintained constant at 1500.

objective:
By using a digital volume flow metre, hydrogen was injected at three different volume flow rates, namely 3, 6, and 9 lpm. Engine combustion, emission, and performance parameters were evaluated for different hydrogen flow rates and compared to sole diesel.

method:
The result revealed that brake thermal efficiency of the engine increased, whereas the brake specific fuel consumption decreased due to hydrogen enrichment. The hydrocarbon and carbon monoxide emissions were lower in dual fuel mode when compared to sole diesel operation under all load situations.

conclusion:
Among the evaluated H2 flow rates, 9 lpm is found to be the best, demonstrated enhanced engine characteristics.
Pengaruh Motivasi dan Pemberian Kompensasi Terhadap Loyalitas Karyawan di Hotel Four Points By Sheraton Bali Seminyak
Authors: Dharmadi I Putu Aditya , Parwati Komang Shanty Murni , Tunjungsari Komang Ratih 
Published: April 2023

Loyalitas karyawan sangat penting bagi pertumbuhan produktivitas perusahaan. Tujuan penelitian ini untuk mengetahui signifikansi pengaruh Motivasi dan Kompensasi terhadap Loyalitas Karyawan. Populasi dalam penelitian ini sebanyak 77 orang. Jumlah sampel diambil sebanyak 65 orang. Teknik ini menggunakan metode teknik quota sampling. Teknik analisis data menggunakan regresi linier berganda. Pengujian hipotesis ini dilakukan pada tingkat signifikansi 5%. Penelitian ini menunjukan hasil bahwa motivasi dan kompensasi berpengaruh positif dan signifikan secara simultan dan parsial terhadap loyalitas karyawan. Berdasarkan hasil penelitian ini, diharapkan manajemen dapat meningkatkan loyalitas karyawan dalam bentuk memberikan bonus atau reward, memberikan kompensasi kepada karyawan yang bekerja secara over time.

Employee loyalty is very important for the growth of company productivity. The purpose of this study was to determine the significance of the effect of motivation and compensation on employee loyalty. The population in this study were 77 people. The number of samples taken as many as 65 people. This technique uses the quota sampling technique method. The data analysis technique used multiple linear regression. This hypothesis testing was carried out at a significance level of 5%. This study shows the results that motivation and compensation have a positive and significant effect simultaneously and partially on employee loyalty. Based on the results of this study, it is expected that management can increase employee loyalty in the form of giving bonuses or rewards, providing compensation to employees who work over time.
Mangrove the Head of an Intricate Joint Family
Authors: Mukhopadhyay Aju 
Published: April 2023

A study of Mangrove is one of the wondrous experiences of man. Mangroves are one of the unique systems of vegetation in Nature; they live in symbiotic relationship with all creatures in and around its zone. It has not only its bounty but it protects humans and other creatures including the environment from external violence from Nature and other where.

It is one of the most familiar forms of vegetation occurring in the intertidal zones along coasts and river banks in the coastal areas in tropical and subtropical countries of the world. Mangrove forests are highly productive ecosystems and are a natural, renewable resource. They provide essential goods and services and play a very important role in the lives of men; coastal communities and others living in their surroundings.

Indonesia has the largest total area of mangrove forest while the Sundarbans swamp region in Bangladesh and India is the largest single chunk of mangrove forest in the world. Sundarbans is listed as a UNESCO World Heritage Site. Conservation and development of such natural systems benefit man and his environment. It is man’s duty to preserve, protect and develop such a great creation of Nature.
5. Visual Communication in Cultural Media. The Rashomon Effect in the Image Globalization Paradigm
Authors: Soreanu Cătălin , German Lavinia 
Published: April 2023

Abstract
The nowadays communication paradigm shifts in the context of new media emergence, as we consider the internet and social media as sovereign communicative mediums. From cinema to press, advertising, art, or new-mediatic context, we assist to a global communication process which encompasses both the technological virtues of digitality, and the subjective truths of a collective cultural memory process. Based on the active principle of “the Rashomon effect,” we will investigate the advertising patterns, the news dissemination, and the everyday culture of images, and we will attempt to summarise the outcome of our position as (inter)active players in this globalised media environment. Since we are both creators and consumers of cultural information in the “global village,” we work with a wide array of communication supports which define our very identity as “information matrix processors.” We are creating both the context and the vehicle of this paradigm where the information is the main currency, and the visual communication become a medium by itself which opens a variety of directions of analysis for critical understanding of today’s cultural phenomenon
10. Unage Iași Art Residency. International Visual Arts Residency Program. Emery Hall, American Artist Resident
Authors: Pantea Andrei Alecsandru , Palamar Ioana 
Published: April 2023

Abstract
Iași Art Residency is an artistic residency program that takes place in Iasi and involves the monthly invitation of an international visual artist, in order to materialize a specific art project related to the experience lived in the cultural space of Iasi. The program aims to connect the students of the Faculty of Visual Arts and Design within “George Enescu” National University of Arts in Iași with the invited artists, in order to exchange artistic experiences. This article will briefly present the activity of the American resident artist Emery Hall which took place here, in Iasi,in May and June 2022.
8. The Dramatic Literary Text as an Art Object in the Process of Teaching/Learning the French Language in the University Context
Authors: Gagim Ion , Chiriță Mariana 
Published: April 2023

Abstract
The given article focuses on the study of the dramatic literary text as an art object used in the process of the teaching/learning French as a foreign language. The dramatic literary text, being one of the main elements of the dramatic art, which in turn is a syncretic one, requires an integrated approach in the interpretation process, both as a literary product and as a performance.
10. Ecology of Information, a Beneficial Comprehensive Approach in Arts Higher Education
Authors: Grigoraș Florin 
Published: April 2023

Abstract
Recent research carried out in various fields of knowledge have led to significant results, which are also decisively imposed in the sphere of the arts. These contributions expand not only the area of artistic practices (new means of artistic production are established), but also the range of approaches from art theory, related to these practices. Our study illustrates this fact through a review of the scientific literature: articles, specialized publications, monographs and programmatic documents of some relevant institutions. The complexity of the information constellation in which the practice and theory of art are circumscribed, in the recent period, is thus highlighted, which necessarily leads to new specific requirements regarding the instructional design in the field of arts higher education.
Analysis of the Relationship Between the Development of Performance Criteria and Job Performance of Employees with Respect to the Mediating Role of Employee Participation
Authors: Fallahnejad Ali , Nazari Reza , Fard Mehdi Moradzadeh 
Published: April 2023

Abstract
The main purpose of this study is to investigate and analyze Positive and significant impact of defining employee performance criteria with the objectives: evaluation, empowerment and career development on the job performance of Keshavarzi Bank of Iran employees with regard to the mediating role of employee participation. The present study was based on the purpose of applied research and in terms of the method was a descriptivesurvey study. A questionnaire was used to collect research data. The statistical population of the present study consisted of senior and middle managers of the Keshavarzi Bank of Iran who had at least 5 years of work experience. The number of these people in the initial studies was estimated at 483 and finally, using Cochran's formula, 215 people were selected as the sample size. After collecting data through a questionnaire, data analysis was performed using structural equation modeling. The results showed that the development of performance criteria with the objectives of evaluating, empowering, and developing the career path of employees has a positive and significant effect on the job performance of employees of the Keshavarzi Bank of Iran. Supplementary results also showed that employee participation in the relationship between the three objectives of developing performance criteria and job performance of employees has an effective mediating role, so this effect in the relationship between performance criteria to develop a career path and job performance of employees with the path coefficient of 0.684 is very obvious. Accordingly, it can be said that since employee participation is the basis for the development of service organizations such as banks, by implementing measures related to employee participation and benefiting from employees' opinions in formulating performance criteria, preparations for achieving an effective performance management system. And thus accelerated the movement of the Keshavarzi Bank of Iran on the path of development.
Analisis Risiko Keselamatan dan Kesehatan Kerja pada Pekerja Industri Pembuatan Batu Bata di Korong Tanjung Pisang Nagari Sintuk Kabupaten Padang Pariaman
Authors: Fitriyani Fitriyani , Gusti Aria , Hermawati Fauziah 
Published: April 2023

Berdasarkan hasil survei ILO tahun 2018 menyebutkan bahwa di Indonesia terjadi kecelakaan kerja sebanyak 29 kasus yang mengakibatkan kematian dalam 100.000 pekerja Indonesia dan sebanyak 380.000 (13,7%) pekerja meninggal setiap tahunnya karena kecelakaan kerja. Aktifitas pekerja industri batu bata berisiko untuk menyebabkan kecelakaan kerja seperti tertimpa batu bata hingga kebakaran, dan penyakit akibat kerja seperti low back pain, infeksi saluran pernapasan akut, dermatitis dan penyakit kulit lainnya, dan kerusakan kuku. Metode penelitian menggunakan pendekatan kualitatif dengan desain crossectional. Kegiatan dilakukan dari April - Oktober 2021 dengan metode wawancara dan observasi. Analisis menggunakan standar AS/NZS 4360:2004 dan formulir Job Safety Analysis (JSA). Hasil penelitian didapatkan dari 19 tahapan kerja, 4 tahapan kerja kategori risiko ektrim, 10 tahapan kategori risiko tinggi, 3 tahapan kerja kategori risiko sedang, dan 2 tahapan kerja kategori risiko rendah. Kesimpulan, diperlukan alat bantu kerja seperti mesin pengaduk, penggunaan sarung tangan, topi dan sepatu boots dalam bekerja dan pengaturan jam kerja.
Kata Kunci : Kesehatan Kerja, Keselamatan Kerja, JSA, Pekerja batu bata