bluuebunny/crossref_metadata_2025_split huggingface dataset:
Retzius-sparing vs. posterior urethral suspension: similar early-phase post-robotic radical prostatectomy continence outcomes
Authors: Kominsky Hal D , Awad Mohannad A , Farhi Jacques , Gahan Jeffrey C , Cadeddu Jeffrey A. 
Published: August 2023

Abstract
Introduction
Stress urinary incontinence (SUI) is a risk of robotic-assisted radical prostatectomy (RP) that can be a frustrating problem for both surgeons and patients. We aim to compare short term continence outcomes between patients undergoing Retzius Sparing RP (RS-RP) and those undergoing standard RP with inclusion of a PUS suture technique and suprapubic tube (PUS-RP).
Materials and Methods
A retrospective review of 105 consecutive patients who underwent RP was performed, comparing patients who underwent RS-RP and PUS-RP. Our main outcome was pad usage as a surrogate for SUI. Patients were evaluated 4 weeks following RP and again at approximately 3 months. Continence was defined as no pad usage or up to one safety pad per day. Risk factors associated with not being continent were identified using univariate and multivariate analyses.
Results
In our cohort, 52 patients underwent RS-RP and 53 patients underwent PUS-RP. The two groups had similar patient demographics. Although not statistically significant, there was a higher rate of a positive surgical margin in the RS-RP compared to PUS-RP (25% vs 15%, p = 0.204). At one month follow up for PUS-RP and RS-RP, there was no significant difference in frequency of continent men (69.2% vs. 76.9%, p = 0.302). At 3 month follow up for the two groups of patients, again, there was no significant difference in frequency of continence for PUS-RP and RS-RP (86.2% vs 88%, p = 0.824).
Conclusion
Patients who underwent RS-RP had similar rates of continence to those patients undergoing PUS-RP in the short term post-operative period.
Optimised Sparse Image Reconstruction via Densification and Relocation
Authors: Kang Hyoseung , Chizhov Vassillen , Augustin Matthias 
Published: August 2023

Abstract
We propose a novel data optimisation technique for sparse image reconstruction, which is useful for image compression and adaptive signal processing. Due to its nonconvexity, the optimisation problem for sparse image reconstruction is challenging. The proposed method relies on a simple-to-use framework applicable to numerous linear image reconstruction operators, such as splines and linear partial differential equation (PDE)-based inpainting. Our approach convincingly outperforms several established algorithms in terms of reconstruction quality and efficiency, thanks to a combinatorial optimisation for the initial guess and a continuous optimisation for further improvements. Moreover, we present a comparison among a set of highly competitive methods for image reconstruction. To our knowledge, this set of methods has not been thoroughly compared with optimised data previously.
MSC: 65K10, 65D07, 90C59
The Hunt for antipox compounds against Monkeypox Virus Thymidylate Kinase and scaffolding protein leveraging Pharmacophore modeling, molecular docking, ADMET Studies, and molecular dynamics simulation studies
Authors: Ssemuyiga Charles , Ssemanda Paul , Pius Edgar Mulumba , Kasoma Anthony Ndugwa , Ntambi Saidi 
Published: August 2023

Abstract
Cases of the monkeypox virus have been recorded in non-endemic nations and have continued to be reported in several endemic nations since early May 2022 [1]. In this study, we modeled MPXV Thymidylate Kinase (TMPK) and scaffolding protein (D13), and these models and their templates were taken for small molecule screening against 602,413 small molecules using pharmacophore modeling and molecular docking methods. ADMET properties were also computed followed by Molecular simulation dynamics studies. All presented hits had superior molecular docking scores to used reference standards of Cidofovir and Rifampicin. TMPK compounds displayed better ADMET profiles than D13 compounds, hence the latter may necessitate optimization. Following molecular dynamics simulation, calculations of the RMSDs, RMSFs, Hydrogen Bonds, SASA, Radius of Gyration, MM-GBSA energy, PCA, and DCC revealed that all generated complexes were stable, with the ligands NPC275538, NPC244454, 135566871, and CHEBI compounds outperforming other Hits. These compounds still presented higher docking scores against cidofovir-resistant TMPK and Rifampicin-resistant D13 proteins. Compounds 447970, 446595, and 54723327 were most selective against human TMPK. The conserved interaction patterns of these compounds among Vaccinia and Monkeypox virus proteins with the fact that studied proteins are highly conserved across Orthopoxviruses (OPV) is appealing to the fact these hits should be studied across OPV. Therefore, these compounds should be subjected to laboratory testing to prove their antipox capability. Since there are currently no approved MPXV antivirals, this discovery significantly aids in developing new drugs for treating monkeypox.
Modest geoengineering side effects predicted by an emulator
Authors: Bodai Tamas , Lembo Valerio , Aneesh Sundaresan , Ishuzu Miho , Franz Matthias O. , Chung Eui-Seok 
Published: August 2023

Abstract

Side effects of solar radiation management geoengineering are unavoidable because the forcing involved is different in nature from the anthropogenic greenhouse forcing. Yet, the side effects should scale with the magnitude of the geonegineering forcing. Even then it is crucial to have detailed information about them. We use a response theory based emulator derived from new simulation output for the Max Planck Institute’s Earth system model, MPI-ESM, in order to evaluate the side effects in a scenario where CO2 emission abatement could also achieve the same constraint on peak global surface temperature. We find that the spatial patterns of the side effects for both annual mean surface air temperature and precipitation bear the same features as those known from the G2-type “cancellation” experiments of the Geo-MIP protocol.
Analisis Kemampuan Pemecahan Masalah Word Problem PLSV
Authors: Hidayah Siti Lilpatul Nurul Nur , Prayitno Lydia Lia 
Published: August 2023

Problem-solving ability is a primary skill students should acquire in learning mathematics and is often connected to Adversity Quotient (AQ). This qualitative descriptive study describes the ability to solve PLSV problems regarding AQ (climbers, campers, and quitters) in 7th-grade students of SMP Negeri 21 Surabaya. Data were collected through questionnaires, tests, and interviews using instruments such as the AQ questionnaire sheet, Word Problem Solving Test (TPWP), questionnaires, and interview guidelines. The problem-solving ability in this study refers to the four stages of Polya's problem-solving ability including understanding the problem, planning, implementing, and evaluating. The results of this study showed that (1) the climbers subject was able to accomplish all of Polya's stages, (2) the campers subject, was able to accomplish three stages of Polya's problem solving, which were able to understand the problem, plan the problem solving, and carry out the problem-solving. Whereas, (3) the quitters subject, was unable to complete Polya's problem-solving stages as it showed that the subject was poorly understanding the problem, planning to solve the problem, implementing the solution plan, and incapable of looking back at problems that had been solved.
The kinetic effect induced by variable cooling rate on the crystal-chemistry of spinel in basaltic systems revealed by EPMA mapping
Authors: Gennaro Emanuela , Iezzi Gianluca , Nazzari Manuela , Vetere Francesco , Scarlato Piergiorgio , Giuliani Letizia , Zellmer Georg F. 
Published: August 2023

Abstract
The crystal-chemical variations of spinels grown as a function of cooling rate (ΔT/Δt) were analyzed via X-ray electron-microprobe (EPMA) maps. Maps were collected serially by using a fixed distance. Spinels solidified from a tholeiitic MOR basaltic liquid (B100) cooled at cooling rates (ΔT/Δt) of 1, 7, 60, and 180 °C/h, between 1300 and 800 °C and at ambient P and fO2. As ΔT/Δt increases, the amount of spinel is invariably &lt;5 area% and its size decreases. Compared to the previous data set collected by common single and selected EPMA analytical points (112 analyses), the kinetic effects induced by ΔT/Δt are here quantitatively captured by a large number of analyses (2052).
The TiO2, Al2O3, MgO, and FeOtot show large compositional variations at low cooling rates (from 1 to 60 °C/h), and only the average TiO2 concentration shows a well-defined trend as a function of ΔT/Δt. However, calculated average cation amounts (apfu) unveil quantitative kinetic effects. When ΔT/Δt increases (from 1 to 180 °C/h), only Ti4+ shows a linear decreasing trend, whereas the other major Al3+, Fe3+, Fe2+, and Mg2+ cations alone are scattered. Conversely, the sums of trivalent (Al3++Fe3+) and divalent (Mg2++Fe2+) cations quantitatively capture the effect of the ΔT/Δt. These new outcomes could be the base of novel geospeedometers with significant implications in volcanology, geophysics, and material sciences in regard to silicate melt rheology on Earth. They should be extended to high-pressure, hydrated, and low oxygen fugacity conditions. Furthermore, the analytical approach used here to capture kinetic effects on spinel growth and compositions can be also applied to other crystalline phases grown from silicate liquids.
What’s on Dr. Barnhardt’s mind?
Authors: Rooney Barnhardt Tera 
Published: August 2023

Imposter syndrome is a term that was introduced to me at a recent graduate conference that I attended for the American Association of Bovine Practitioners. It resonated with me and other highly-driven individuals sitting in the room. I felt as thought it made a lot of sense. As I have progressed in my ca­reer, I have decided that it doesn’t actually need to be given so much credit. Many times, what we mistake as a moment of discomfort or inadequacy, is the moment we will see the most growth and change in ourselves personally and professionally if we just move forward.
Mentorship is something our age cohort prefers to experience professionally and it is a relationship that deserves both parties to put effort and energy towards. If we are going to demand this, we need to support it from our side of the relationship also.
Nutritional significance of finger millet and its potential for using in functional products
Authors: Gaikwad Vaibhav , Kaur Jaspreet , Rasane Prasad , Kaur Sawinder , Singh Jyoti , Kumar Ankit , Kumar Ashwani , Sharma Nitya , Mehta Chandra Mohan , Patel Avinash Singh 
Published: August 2023

Finger millet (Eleusine coracana L.), ragi or mandua, is one of essential minor millets extensively grown in the Indian and African subcontinents. It is a staple food in India, particularly for people belonging to low-socioeconomic groups. Finger millet is highly valued for its content of macro- and micronutrients. It is rich in carbohydrates, protein, and fat. Its micronutrients include calcium (0.38%), dietary fiber (18%), and phenolic compounds (0.3–3%), such as catechin, epicatechin, as well as ferulic, salicylic, protocatechuic, cinnamic, and hydroxybenzoic acids, etc. Finger millet is also recognized as a source of vital amino acids, including isoleucine, leucine, methionine, and phenylalanine, which are otherwise deficient in starchy meals. In addition, finger millet is well appreciated for its pharmacological properties such as anti-diabetic, anti-tumorigenic, anti-atherosclerogenic, antioxidant, and antimicrobial effects. To improve its nutritional and sensory properties, this grain can be processed by various traditional and advanced methods (soaking, malting, cooking, fermentation, popping, and radiation). These processing techniques equally assist in the reduction of anti-nutritional factors (tannins, phytic acid, oxalic acid, protein inhibitors, glucans) and their inhibitory effects. In this review, we highlighted the nutritional composition, health attributes, and uses of finger millet for the development of functional food products.
Researchers and producers can further explore the opportunities and scope for utilizing finger millet and develop more products in the same line to solve the current issues of food and nutrition security.
Coupled sink and flow accumulation analyses with single flow direction and multiple flow direction algorithms
Authors: Bowsher Nicholas Ray , Sieker Heiko , Hinkelmann Reinhard 
Published: August 2023

Abstract

A static flood analysis (SFA) toolset is implemented with the purpose of performing simplified, event-based flood inundation modeling. The simulation process is divided into two steps: a topographic sink analysis of the terrain followed by flow accumulation (FA) of runoff volumes. Both procedures are coupled to account for sink storage effects. The sink analysis procedure determines the morphology of present sinks that are utilized during FA to calculate the sink storage by solving a mass balance, whereby inflows are captured in each sink according to their capacity and overflows are routed further downstream. Each sink is enriched with a set of hydrological attributes such as the total inflow, overflow, and flood depth. The flood depth is then utilized to determine the flood extent and flood depths of each sink. Two main options are made available for the FA procedure: either a single flow direction (SFD) or a novel formulation of the multiple flow direction (MFD) algorithm. Both methods were compared in terms of their accuracy with results from the TELEMAC-2D finite-volume solver for an urban inundation model. Both methods showed good agreement when compared with the validation results, with the MFD method performing marginally better than the SFD method.
The Cosmos and Human Beings from an Interdisciplinary Perspective. “Paradigmatické zmeny v chápaní kozmologickej a antropologickej problematiky. Minulosť a súčasnosť,” [“Paradigmatic Changes in the Understanding of Cosmological and Anthropological Issues. Past and Present”] edited by Zlatica Plašienková, Univerzita Komenského v Bratislave, Bratislava 2021, pp. 308 (rev.)
Authors: Zolcer Štefan 
Published: August 2023

This book presents a complex picture of the universe and man from historical and contemporary perspectives, including philosophical, theological, and scientific perspectives. It consists of several papers by authors from various fields, and it is divided into three main parts. The first part addresses some interesting questions from the history of philosophy and theology; the second part focuses on contemporary astrophysics and astrobiology and the question of extraterrestrial life; the third part considers the ethical and environmental dimensions of these questions.
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Received: 19/02/2023. Reviewed: 17/03/2023. Accepted: 30/03/2022.
Use of Post-mortem Brain Tissue in Investigations of Obsessive-
Compulsive Disorder: A Systematic Review
Authors: Lochner Christine , Naudé Petrus J.W. , Stein Dan J. 
Published: August 2023

Background:
Post-mortem examination of the brain is a key strategy to increase our understanding
of the neurobiology of mental disorders. While extensive post-mortem research has been undertaken
on some mental disorders, others appear to have been relatively neglected.

Objective:
The objective of the study was to conduct a systematic review of post-mortem research on
obsessive-compulsive disorder (OCD).

Methods:
A systematic review was performed in accordance with PRISMA guidelines to provide an
overview of quantitative, qualitative, or mixed methods primary research studies on OCD. Search platforms
included NCBI Pubmed, SCOPUS, and Web of Science.

Results:
A total of 52 publications were found, and after the removal of works not meeting the inclusion
criteria, six (6) peer-reviewed publications remained. These post-mortem studies have provided
data on DNA methylation, cellular and molecular alterations, and gene expression profiling in brain
areas associated with OCD.

Discussion and Conclusion:
Included studies highlight the potential value of post-mortem brains from
well-characterized individuals with OCD and suggest the need for additional work in this area.
Identification of the Roles of Coagulation-related Signature and its Key
Factor RABIF in Hepatoma Cell Malignancy
Authors: Chen Yanying , Li Yin , Zhou Bingyi 
Published: August 2023

Background:
Hepatoma is a high morbidity and mortality cancer, and coagulation is a
potential oncogenic mechanism for hepatoma development

Objective:
In this study, we aimed to reveal the role of coagulation in hepatoma.

Methods:
We applied the LASSO to construct a coagulation-related risk score (CRS) and a clinical
nomogram with independent validation. The heterogeneity of various aspects, including functional
enrichment, SNV, CN, immunocyte infiltration, immune pathways, immune checkpoint,
and genomic instability indexes, was evaluated. Besides, the prognostic value of the CRS genes
was tested. We selected the critical risky gene related to coagulation from the LASSO coefficients,
for which we applied transwell and clone formation assays to confirm its roles in hepatoma cell
migration and clone formation ability, respectively.

Results:
The CRS and the nomogram predicted patients’ survival with good accuracy in both two
datasets. The high-CRS group was associated with higher cell cycle, DNA repair, TP53 mutation
rates, amplification, and lower deletion rates at chromosome 1. For immunocyte infiltration, we
noticed increased Treg infiltration and globally upregulated immune checkpoints and genomic
instability indexes. Additionally, every single CRS gene affected the patient’s survival. Finally,
we observed that RABIF was the riskiest gene in the CRS. Its knockdown suppressed hepatoma
cell migration and clone formation capability, which could be rescued by RABIF overexpression.

Conclusion:
We built a robust CRS with great potential as a prognosis and immunotherapeutic
indicator. Importantly, we identified RABIF as an oncogene, promoting hepatoma cell migration
and clone formation, revealing underlying pathological mechanisms, and providing novel therapeutic
targets for hepatoma treatment.
Impact of Parental Aggression on Primary School Teachers’ Everyday School Life and Well-being
Authors: Sklirou Sotiria , Papakonstantinou Antigoni-Alba 
Published: August 2023

According to international research, parental aggression is observed in school premises, and it usually has a negative impact on schools’ climate and on actors’ social interactions. Parental aggression in school premises is a phenomenon not sufficiently studied in Greece. The aim of the present study was to fill the bibliography gap and to examine the impact of parental aggression on teachers’ everyday school life and well-being. Thus, a quantitative study was conducted, and an explanatory correlational design was used for the collection and analysis of the research data. Our target population was primary school teachers. 156 primary school teachers in Attica participated in our research by filling in an original questionnaire of closed-ended questions. According to the findings of the research, parental aggression is clearly observed in school premises. Parental aggression affects students, it influences the emotional state of teachers and has a negative impact on their everyday school life and well-being. Although aggression can be harmful to all teachers, specific individual characteristics of teachers (such as gender, age, working experience) can magnify certain impacts of aggression.
Upaya Menumbuhkan Stimulus Respon Peserta Didik Melalui Penerapan Teori Belajar Behavioristik
Authors: Almizri Wahyu , S Neviyarni 
Published: August 2023

Abstract: The purpose of this study is to describe the applications and benefits used by teachers in stimulating student stimulus responses through behavioristic theory. This research method using literature study. The data collection tool used is through searching scientific journals that I took from several electronic media. The data analysis technique used in this study is annotated bibliography analysis. This research boils down to the conclusion that the teacher in applying behavioristic theory to stimulate student response stimulus is that the teacher must understand the differences in student learning styles and their respective characteristics, the readiness of students to learn must also be considered by the teacher, and the teacher provides good modeling/imitation to students.

Keywords: behavioristic theory, learning style
Pengaruh Pengelolaan Kelas di Sekolah
Authors: Nasution Salsabila , S Neviyarni 
Published: August 2023

Classroom management is a teacher's skill in order to create a pleasant learning atmosphere, and can control it if there are disturbances during learning. The aim of this research is to find out how much influence the classroom management has on students by the teacher. This research also aims to compare the effects of classroom management that have the greatest impact on students. The method in this research is a literature study by collecting library data from several sources of scientific research in accordance with classroom management from 2017-2022. The results of a literature study conducted by researchers related to the effect of classroom management on students at school can be concluded that classroom management is very influential for several aspects of student learning including student learning motivation, student achievement, student learning outcomes, student understanding, student activity, and attitudes student. Among the several aspects that are affected by classroom management, learning achievement is very dominant and has been found and carried out by many people.
Keywords: Influence, Classroom management, Teachers, students
PENGEMBANGAN MEDIA PEMBELAJARAN INTERAKTIF MENGGUNAKAN ARTICULATE STORYLINE MATA PELAJARAN IPA KELAS VIII SMP
Authors: Kristi Anggel , Zuliarni Zuliarni 
Published: August 2023

The development of interactive learning media using Articulate Storylinejis carried out asjan effortjtojhelp teachers in thejlearning process become better, because when learning uses the lecture method, thejusejof power point learningjmediajis only dominated by writing andjthe usejof learning media. teachingjmaterialsjin thejformjof worksheets and textbooks. With interactive learning media using an articulate storyline, it can help teachers in the learning process, so that learning is more interesting for students to follow. Thisjstudyjaims tojproduce ajvalid and practical Articulate Storyline learning media on optical instruments. This type of research is development research or what is known as Research and Developmentj (R&D). jThisjstudy uses the development modeljproposedjby Brag and Gall which is simplified into 5 steps, namely planning, initial product development, product validation, limited trial, and final product. The product developed was assessed by 2 material validators, namely a science subject teacher at SMP N 25 Padang and 2 media validators, namely a lecturer in the curriculum and educational technology department. The assessment ofjthe practicality test was carriedjoutjby 15 grade VIII students of SMP N 25 Padang.
Thejproductjvalidity testjresultsjforjthe materialjaspectjare categorized as "very valid" by obtaining an average of 4.2 from the material validator I and obtaining an average of 4.7 from the material validator II. Thejresultsjofjthe validity assessment for thejmedia aspect are categorizedjas "very valid" by obtaining anjaverage of 4.4 from the media validator I and obtaining an average of 4.54 from the media validator II. Thejresultsjofjthe practicality test conducted by 15 grade VIII students at SMPjN 25 Padang werejcategorizedjas "very practical" withjanjaveragejscore of 4.6. learning and asjajlearning resourcejforjstudents.