bluuebunny/crossref_metadata_2025_split huggingface dataset:
Invasive fungal diseases in patients with autoimmune diseases: a case series from the French RESSIF network
Authors: Galmiche Simon , Thoreau Benjamin , Bretagne Stéphane , Alanio Alexandre , Paugam André , Letscher-Bru Valérie , Cassaing Sophie , Gangneux Jean-Pierre , Guegan Hélène , Favennec Loïc , Minoza Alida , Morio Florent , Bonhomme Julie , Desoubeaux Guillaume , Eloy Odile , Hasseine Lilia , Sasso Milène , Millon Laurence , Bellanger Anne-Pauline , Poirier Philippe , Moniot Maxime , Chouaki Taieb , Huguenin Antoine , Dalle Frédéric , Bouteille Bernard , Nicolas Muriel , Desbois-Nogard Nicole , Bougnoux Marie-Elisabeth , Danion François , Poindron Vincent , Néel Antoine , Boukris-Sitbon Karine , Lanternier Fanny , Terrier Benjamin 
Published: September 2023

ObjectivesWe aimed to describe patients with autoimmune diseases (AID) developing invasive fungal disease (IFD) and identify factors associated with short-term mortality.MethodsWe analysed cases of IFD associated with AID from the surveillance network of invasive fungal diseases (Réseau de surveillance des infections fongiques invasives, RESSIF) registry of the French national reference centre for invasive mycoses. We studied association of AID-specific treatments with 30-day mortality. We analysed total lymphocyte and CD4-T cell counts in patients withPneumocystis jiroveciipneumonia (PCP).ResultsFrom 2012 to 2018, 549 individuals with IFD and AID were included, mainly with PCP (n=227, 41.3%), fungemia (n=167, 30.4%) and invasive aspergillosis (n=84, 15.5%). Rheumatoid arthritis (RA) and anti-neutrophil cytoplasmic antibodies (ANCA)-associated vasculitides (AAV) were the most frequent AID in PCP (n=55 and 25, respectively) and invasive aspergillosis (n=15 and 10, respectively), inflammatory bowel diseases (IBDs) were predominant in fungemia (n=36). At IFD diagnosis, 365 (66.5%) patients received glucocorticoids (GCs), 285 (51.9%) immunosuppressants, 42 (7.7%) tumor necrosis factor (TNF)-α blockers, 75 (13.7%) other biologics. Mortality at 30 days was 28.1% (143/508). Fungemia and high-dose GCs were independently associated with higher 30-day mortality. In PCP patients, lymphopenia <1500/mm3was frequent (132/179, 73.7%) even if CD4+T cell count exceeded 200/mm3in 56/78 patients (71.8%) (median 472.5/mm3, IQR 160–858).ConclusionIFD associated with AID occurs primarily in RA, AAV and IBD, especially when treated with GCs and immunosuppressants. Mortality is high, especially for patients on high-dose GCs. Lymphopenia may help identify risk of PCP, but normal CD4+T cell count does not rule out the risk. Further studies are needed to assess the individual risk factors for IFD.
Survey on surgical treatment of neonatal necrotizing enterocolitis in China 2022
Authors: Gao Jiafang , Lai Dengming , Tou Jinfa 
Published: September 2023

ObjectiveThe aim of this study was to identify the state of surgical treatment of neonatal necrotizing enterocolitis (NEC) in China.MethodsA total of 246 delegates (88.0% senior surgeons) completed a survey sent by the Neonatal Surgery Group of the Pediatric Surgery Branch of the Chinese Medical Association in 2022. Five centers were eliminated due to lack of experience.ResultsGenerally, 38.2% of surgeons work in centers where more than 20 cases of surgical NEC are treated per year. A total of 81.3% of surgeons reported the use of ultrasonography; the most used biomarkers were white blood cell count (95.9%), C-reactive protein (93.8%), and procalcitonin (76.3%). Most surgeons (80.9%) used a combination of two (67.2%) antibiotics or single (29.5%) antibiotic for a treatment period of 7–14 days, and most used antibiotics were carbapenems (73.9%), penicillin and cephalosporins (56.0%). Patients are issued the fasting order for 5–7 days by nearly half surgeons (49.8%) for conservative treatment. 70.1% of surgeons deemed that the most difficult decision was to evaluate the optimal timing of surgery. Most surgeons (76.3%) performed diagnostic aspiration of peritoneal fluid. Laparoscopy was performed for the diagnosis and/or treatment of NEC by 40.2% of surgeons. A total of 53.5% of surgeons reported being able to identify localized intestinal necrosis preoperatively. Surgeons relied the most on pneumoperitoneum (94.2%) and failure of conservative treatment (88.8%) to evaluate the surgical indications. At laparotomy, surgical treatments vary according to NEC severity. Infants are fasted for 5–7 days by 55.2% of surgeons postoperatively. Most surgeons (91.7%) followed up with patients with NEC after discharge for up to 5 years (53.8%).ConclusionsThe most difficult aspect of surgical NEC is evaluating the timing of surgery, and surgeons in the children’s specialized hospitals are experienced. The treatment of NEC totalis is controversial, and the indications for laparoscopy need to be further clarified. More multicenter prospective studies are needed to develop surgical guidelines in the future.
Semantic Collaborative Learning for Cross-Modal Moment Localization
Authors: Hu Yupeng , Wang Kun , Liu Meng , Tang Haoyu , Nie Liqiang 
Published: September 2023

Localizing a desired moment within an untrimmed video via a given natural language query, i.e., cross-modal moment localization, has attracted widespread research attention recently. However, it is a challenging task because it requires not only accurately understanding intra-modal semantic information, but also explicitly capturing inter-modal semantic correlations (consistency and complementarity). Existing efforts mainly focus on intra-modal semantic understanding and inter-modal semantic alignment, while ignoring necessary semantic supplement. Consequently, we present a cross-modal semantic perception network for more effective intra-modal semantic understanding and inter-modal semantic collaboration. Concretely, we design a dual-path representation network for intra-modal semantic modeling. Meanwhile, we develop a semantic collaborative network to achieve multi-granularity semantic alignment and hierarchical semantic supplement. Thereby, effective moment localization can be achieved based on sufficient semantic collaborative learning. Extensive comparison experiments demonstrate the promising performance of our model compared with existing state-of-the-art competitors.
Nimodipine Reduces Microvasospasms After Experimental Subarachnoid Hemorrhage
Authors: Schwarting Julian , Harapan Biyan Nathanael , Lin Xiangjiang , Plesnila Nikolaus , Terpolilli Nicole A. 
Published: September 2023

BACKGROUND:
The only established pharmacological treatment option improving outcomes for patients suffering from subarachnoid hemorrhage (SAH) is the L-type-calcium channel inhibitor nimodipine. However, the exact mechanisms of action of nimodipine conferring neuroprotection after SAH have yet to be determined. More recently, spasms of the cerebral microcirculation were suggested to play an important role in reduced cerebral perfusion after SAH and, ultimately, outcome. It is unclear whether nimodipine may influence microvasospasms and, thus, microcirculatory dysfunction. The aim of the current study was, therefore, to assess the effect of nimodipine on microvasospasms after experimental SAH.

METHODS:
Male C57Bl/6 N mice (n=3–5/group) were subjected to SAH using the middle cerebral artery perforation model. Six hours after SAH induction, a cranial window was prepared, and the diameter of cortical microvessels was assessed in vivo by 2-photon-microscopy before, during, and after nimodipine application.

RESULTS:
Nimodipine significantly reduced the number of posthemorrhagic microvasospasms. The diameters of nonspastic vessels were not affected.

CONCLUSIONS:
Our results show that nimodipine reduces the formation of microvasospasms, thus, shedding new light on the mode of action of a drug routinely used for the treatment of SAH for >3 decades. Furthermore, L-type Ca2+ channels may be involved in the pathophysiology of microvasospasm formation.
Surprisal From Language Models Can Predict ERPs in Processing Predicate-Argument Structures Only if Enriched by an Agent Preference Principle
Authors: Huber Eva , Sauppe Sebastian , Isasi-Isasmendi Arrate , Bornkessel-Schlesewsky Ina , Merlo Paola , Bickel Balthasar 
Published: September 2023

Abstract
Language models based on artificial neural networks increasingly capture key aspects of how humans process sentences. Most notably, model-based surprisals predict event-related potentials such as N400 amplitudes during parsing. Assuming that these models represent realistic estimates of human linguistic experience, their success in modeling language processing raises the possibility that the human processing system relies on no other principles than the general architecture of language models and on sufficient linguistic input. Here, we test this hypothesis on N400 effects observed during the processing of verb-final sentences in German, Basque, and Hindi. By stacking Bayesian generalised additive models, we show that, in each language, N400 amplitudes and topographies in the region of the verb are best predicted when model-based surprisals are complemented by an Agent Preference principle that transiently interprets initial role-ambiguous noun phrases as agents, leading to reanalysis when this interpretation fails. Our findings demonstrate the need for this principle independently of usage frequencies and structural differences between languages. The principle has an unequal force, however. Compared to surprisal, its effect is weakest in German, stronger in Hindi, and still stronger in Basque. This gradient is correlated with the extent to which grammars allow unmarked NPs to be patients, a structural feature that boosts reanalysis effects. We conclude that language models gain more neurobiological plausibility by incorporating an Agent Preference. Conversely, theories of human processing profit from incorporating surprisal estimates in addition to principles like the Agent Preference, which arguably have distinct evolutionary roots.
Interdisciplinarity in Nondisciplines: Archive and Academe in the Study of Religion
Authors: Stepien Rafal K. 
Published: September 2023

Abstract
This article reveals, criticizes, and attempts to overcome the systemic divides between the ideals of an interdisciplinarily employed archive and the realities of a disciplinarily deployed academy. Following an initial section on “Parameters and Proposals” in which I frame the ambit and arguments to follow, in “Religious Studies as Nondiscipline” I argue against the view that religious studies constitutes a discrete discipline. In “Interdisciplinarity and Nondisciplines” I theorize interdisciplinarity and argue for a conceptual relationship between it and the study of religion. Subsequent sections on “Interdisciplinarity in the Practice” and “An Interdisciplinarity in Practice” relate the practical consequences of my account for university-based professional religious studies, and provide an exemplary case study of the alternative approach advanced. Finally, in “Archive and Academe” I draw on contemporary theorizations of the archive to propose the study of religion, as here conceived, to be preeminently located to enact long overdue structural change in academe.
Applying Heterarchy Theory to Ancient Mesopotamian Religions
Authors: Zaia Shana 
Published: September 2023

Abstract
Heterarchy theory is a valuable tool for analyzing complex and changing relationships between elements in a system. It has been employed in anthropology, archaeology, and recently in religious studies. Its utility has not yet been exploited for religions that are studied through textual evidence, such as Mesopotamian religions. As Mesopotamian religions were polytheistic and the texts represent multiple genres from a broad timeframe, relationships between system actors such as gods, temples, and cities defy static and lineal arrangements. Heterarchies are well suited for untangling these relationships, showing how they change depending on the measuring criteria. Using the case of the city of Assur, which housed many deities and was both the religious center and a political capital, heterarchy theory shows how the same elements – temples and cities – reveal different rankings that coexisted simultaneously. Heterarchies productively complicate our understanding of these religious relationships and expose the multimodality of each element in the system.
Émile Belot’s Models, or an Engineer’s Quest for Scientific Legitimacy
Authors: Fages Volny 
Published: September 2023

Abstract
Between 1905 and 1937, Émile Belot, an engineer and then director of a public tobacco factory, threw himself into scientific research seeking to reconstruct the history of the formation of the solar system. This article goes over and analyses the experimental practices Belot drew on in support of his theory, looking at the equipment he manufactured and operated in his “experimental cosmogony laboratory.” Together with a few other French engineers, Belot persistently sought to prove his legitimacy to address astronomical and geological issues. His machines reproducing the formation of spiral nebulae, volcanoes, or lunar craters acted both as material resources for deciding between rival scientific hypotheses, and as tools which, by analogy, materialised the mechanical nature of the cosmos Belot hoped to study without being confined to the scientific margins.
Recirculation of Canada Basin Deep Water in the Amundsen Basin, Arctic
Authors: Karam Salar , Heuzé Céline , Müller Vasco , Zheng Yixi 
Published: September 2023

Abstract
It is evident from hydrographic profiles in the Arctic Ocean that relatively warm and salty Canada Basin Deep Water (CBDW) flows over the Lomonosov Ridge into the Amundsen Basin, in the Eurasian Arctic. However, oceanographic data in the deep Arctic Ocean are scarce, making it difficult to analyze the spatial extent or the dynamics of this inflow. Here we present new hydrographic data from two recent expeditions as well as historical data from previous expeditions in the central Arctic. We use an end-member analysis to quantify the presence of CBDW in the Amundsen and Nansen Basins and infer new circulation pathways. We find that the inflow of CBDW is intermittent, and that it recirculates in the Amundsen Basin along the Gakkel Ridge. Although the forcing mechanisms for the inflow of CBDW into the Amundsen Basin remain unclear owing to the lack of continuous observations, we demonstrate that density-driven overflows, even intermittent, and the pressure gradient across the Lomonosov Ridge are unlikely drivers. We also find multiple deep eddies with a CBDW content of up to 600 g kg−1 and a vertical extent of up to 1200 m in the Amundsen Basin. The high CBDW content of these eddies suggests that they can efficiently trap CBDW and transport its heat and salt over long distances.
Splenic flexure mobilization and anastomotic leakage in anterior resection for rectal cancer: A multicentre cohort study
Authors: Rutegård Martin , Svensson Johan , Segelman Josefin , Matthiessen Peter , Lydrup Marie-Louise , Park Jennifer , Gerdin Anders , Sjöström Olle , Staffan Maria , Jangmalm Staffan , Royson Hanna , Tsimogiannis Konstantinos , Anderin Kajsa , Nygren Jonas , Hurtig Jennie , Golshani Parisa 
Published: September 2023

Background and objective: Some colorectal surgeons advocate routine splenic flexure mobilization (SFM) when performing anterior resection for rectal cancer to ensure a tension-free anastomosis. Meta-analyses of smaller studies suggest that this approach does not influence anastomotic leakage rates, but larger multicentre studies are needed to confirm the safety of a selective strategy. The aim of this study is to evaluate the impact of SFM on anastomotic leakage. Methods: This is a retrospective multicentre cohort study, comprising 1109 patients operated with anterior resection for rectal cancer in 2014–2018. Exposure was SFM, while anastomotic leakage within a year constituted the outcome. Stratified analyses were performed for type of mesorectal excision and surgical approach, as well as sensitivity analysis considering vascular tie placement. Multivariable Cox regression with hazard ratios (HRs) and 95% confidence intervals (CIs) was employed to adjust for confounding, while multiple imputation was used for missing data. Results: SFM was performed in 381 patients (34.4%). Anastomotic leakage occurred in 83 (21.8%) and 123 (20.3%) patients operated with and without SFM, respectively. SFM was neither clearly detrimental nor beneficial regarding anastomotic leakage (adjusted HR = 0.82; 95% CI: 0.59–1.15), with no apparent differences for total or partial mesorectal excision and minimally invasive or open surgery. Concurrent high vascular ligation did not impact these results, and there was no evidence of interaction from centers with a more common use of SFM. Conclusions: SFM did not seem to influence the risk of anastomotic leakage after anterior resection for rectal cancer, regardless of type of mesorectal excision, use of minimally invasive surgery, or high vascular ligation.
Inflammation in the proximal colon is a risk factor for the development of colorectal neoplasia in inflammatory bowel disease patients with primary sclerosing cholangitis
Authors: Jamil Omar K. , Shaw Dustin , Deng Zifeng , Dinardi Nicholas , Fillman Natalie , Khanna Shivani , Krugliak Cleveland Noa , Sakuraba Atsushi , Weber Christopher R. , Cohen Russell D. , Dalal Sushila , Jabri Bana , Rubin David T. , Pekow Joel 
Published: September 2023

Background: Patients with primary sclerosing cholangitis (PSC) and inflammatory bowel disease (IBD) have an increased risk of developing colorectal neoplasia (CRN) in the proximal colon. Objectives: To evaluate whether duration and severity of inflammation are linked to the development of CRN in this population. Design: Retrospective, case–control chart review of patients with PSC and IBD at a tertiary care center. Methods: Disease activity was scored per colonic segment at each colonoscopy prior to the first instance of observed CRN using a modified Mayo endoscopic sub-score and histologic assessment. Patients in the CRN-positive group were compared to controls that did not. Results: In all, 72 PSC-IBD patients with no history of CRN were identified, 13 of whom developed CRN after at least one colonoscopy at our institution. Patients in the CRN-positive group had significantly more endoscopic ( p < 0.01) and histologic ( p < 0.01) inflammation in the right compared to the control group prior to the development of dysplasia. There was significantly greater endoscopic inflammation in the segment of the colon with a dysplastic lesion than other segments of the colon ( p = 0.018). Patients with moderate/severe lifetime endoscopic ( p = 0.02) or histologic inflammation ( p = 0.04) score had a lower probability of remaining free of dysplasia during follow-up. Nearly half of the patients with dysplasia had invisible lesions found on random biopsy. Conclusions: Endoscopic and histologic inflammation in the proximal colon are risk factors for CRN in patients with PSC-IBD. PSC-IBD patients frequently have subclinical inflammation, and these findings support the practice of regular assessment of disease activity and random biopsy of inflamed and uninflamed areas in patients with PSC with the goal of reducing inflammation to prevent the development of CRN.
Perceived COVID-19 Threat, Psychological Distress, and Increases in Alcohol and Cannabis Use at the Onset of the Pandemic in Racially Diverse Emerging Adults
Authors: Marks Laura Reid , Yang Yanyun , Miller Heather H. , Morgan Michael , Yoon Eunhui , Naar Sylvie 
Published: September 2023

We examined the associations among perceived Coronavirus disease 2019 (COVID-19) threat, psychological distress, and perceived increases in alcohol and cannabis use since the onset of the pandemic in a sample of 1,339 Asian, Black, and White emerging adults (18–25 years). We investigated how these relationships changed based on sex assigned at birth, political affiliation, race, and college student status. Correlation analyses demonstrated a significant positive relationship between perceived COVID-19 threat and psychological distress, as well as a significant positive relationship between perceived COVID-19 threat and perceived increases in alcohol use for emerging adults. Multi-group analyses revealed that Black emerging adults displayed the strongest association between perceived COVID-19 threat and perceived increases in alcohol use whereas college students displayed a stronger association between perceived COVID-19 threat and psychological distress than emerging adults not attending college.
Oxygen saturation targets for children with respiratory distress: a systematic review
Authors: Louman Sam , van Stralen Karlijn J. , Pijnenburg Mariëlle W.H. , Koppelman Gerard H. , Boehmer Annemie L.M. 
Published: September 2023

BackgroundIn children with respiratory distress, supplemental oxygen is indicated at peripheral oxygen saturation (SpO2) thresholds of 90–94%. However, these thresholds are poorly studied. We conducted a systematic review to summarise the existing evidence forSpO2thresholds in children with respiratory distress.MethodsElectronic databases and registries were searched for original articles published from 1 January 2010 to 7 January 2022 comparing two or moreSpO2thresholds in children with respiratory distress. Primary outcomes were safety, including mortality, neurocognitive outcomes and readmissions, and effectiveness, including admission rate and length of hospital stay. Methodological appraisal was performed using the Cochrane Risk of Bias 2 (RoB-2) or Risk of Bias in Non-Randomized Studies – of Interventions (ROBINS-I) tools. Results were narratively synthesised.ResultsWe retrieved 3384 results; seven studies were included. Lower thresholds ranged from 80% to 92% and were compared with higher thresholds ranging from 92% to 94%. Studies were highly heterogeneous in setting, design, population and outcomes. Risk of bias varied from low to high. LowerSpO2thresholds had equivalent mortality, neurocognitive outcomes and readmissions or re-attendance to healthcare to higher thresholds. LowerSpO2thresholds showed a significant decrease in admission rates by up to 40% and shortened hospitalisation duration by 10–18 h.ConclusionsThe currentSpO2thresholds of 90–94% in children with respiratory distress may be too high, which could lead to unnecessary hospitalisations and prolonged hospitalisation duration.SpO2thresholds as low as 88% are potentially safe in children with respiratory distress and may reduce hospitalisation rates and length of stay. However, high-quality evidence is needed to support this.