bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluating Electronic Properties of Self‐Assembled Inner Hollow (InAs)12n (n = 1–16) Nanomaterials With High Solar Light‐to‐Electricity Efficiencies Using First Principle Modeling
Authors: Zhao Run‐Ning , Chen Rui , Han Ju‐Guang 
Published: January 2025

ABSTRACTGeometries and electronic properties associated with growth patterns, energy gaps, and relative stabilities of (InAs)12n (n = 1–16) nanowires and nanosheets (nanoclusters) are systemically investigated at the GGA‐PBE level. The relative stabilities of (InAs)12n by means of the calculated fragmentation energies and cluster binding energies are determined and discussed. Particularly, the calculated energy gaps of (InAs)12n nanowires (2.261–2.271 eV) and nanosheets (2.228–2.412 eV) are distinctly localized at the regions of visible light energy ranges, indicating that large‐sized (InAs)12n nanosheets or nanowires are relatively wide‐band semiconductor nanomaterial; the calculated density of states reveals large‐sized porous (InAs)12n nanosheets and nanowires with a large surface area and narrow pore size distribution and slight thickness exhibit ultrahigh specific capacitance of trapping solar light energies and high light‐to‐electricity conversion efficiencies in solar energy absorption or conversion or photovoltaics. Consequently, (InAs)12n‐based nanomaterials are favorable for optoelectronic and energy miniaturized devices. Interestingly, the variable sizes depended energy gaps of (InAs)12n nanosheets manifest quantum size effect. Especially, the gradually increased charge‐transfers in large size (InAs)12n nanowires and nanosheets with their sizes can significantly lead to the ionic bonding and metallic characteristic, which can stabilize themselves. Comparison with experiment results available is made.
Poly(Vinylidene Fluoride‐co‐Hexafluoropropylene) Matrix Nanocomposites Reinforced With Various Types of BaTiO3 Nanoparticles for Flexible Energy Storage Applications
Authors: Koroglu Levent , Tubio Carmen R. , Costa Carlos M. , Ayas Erhan , Lanceros‐Mendez Senentxu , Ay Nuran 
Published: January 2025

ABSTRACTPoly(vinylidene fluoride‐co‐hexafluoropropylene), (PVDF‐HFP), matrix nanocomposites have been prepared by solution casting, reinforced with BaTiO3 nanoparticles (BT NPs) and surface modified BT NPs (BT‐VTS NPs) with a silane coupling agent (VTS) by 0, 5, 15, and 25 wt.%. The effects of filler content and surface modification of nanofillers on the microstructure development, phase evolution, crystallization behavior, and dielectric properties of the nanocomposites are investigated. Furthermore, the energy storage performance of BT‐VTS‐reinforced nanocomposites is evaluated. The surface modification of BT NPs presents some advantages: it prevents aggregation, restricts interface polarization, and keeps dielectric loss of the nanocomposites low as the relative permittivities rise with filler content. 25% BT‐VTS‐reinforced nanocomposites with a β‐phase fraction of 45% and a crystallinity of 14% provide a higher relative permittivity (22. at 1 kHz) than that of the neat PVDF‐HFP thin films (11). Moreover, they present a low loss tangent (0.043) as the neat thin films (0.042). 25% BT‐VTS/PVDF‐HFP nanocomposites demonstrate a discharged energy density of 4.8 J cm−3 at 220 MV m−1 with a charge–discharge efficiency of 26%. Consequently, the energy density of the neat PVDF‐HFP thin films (3.4 J cm−3 at 238 MV m−1) is improved by 40% after the addition of 25% BT‐VTS NPs.
Where in the Milky Way Do Exoplanets Preferentially Form?
Authors: Teixeira Joana , Adibekyan Vardan , Bossini Diego 
Published: January 2025

ABSTRACTExoplanets are detected around stars of different ages and birthplaces within the Galaxy. The aim of this work is to infer the Galactic birth radii () of stars and, consequently, their planets, with the ultimate goal of studying the Galactic aspects of exoplanet formation. We used photometric, spectroscopic, and astrometric data to estimate the stellar ages of two samples of stars hosting planets and, for comparison, a sample of stars without detected planets. The of exoplanets were inferred by projecting stars back to their birth positions based on their estimated age and metallicity [Fe/H]. We find that stars hosting planets have higher [Fe/H], are younger, and have smaller compared to stars without detected planets. In particular, stars hosting high‐mass planets show higher [Fe/H], are younger, and have smaller than stars hosting low‐mass planets. We show that the formation efficiency of planets, calculated as the relative frequency of planetary systems, decreases with the galactocentric distance, which relationship is stronger for high‐mass planets than for low‐mass planets. Additionally, we find that (i) the formation efficiency of high‐mass planets increases with time and encompasses a larger galactocentric distance over time; (ii) the formation efficiency of low‐mass planets shows a slight increase between the ages of 4 and 8 Gyr and also encompasses a larger galactocentric distance over time; and (iii) stars without detected planets appear to form at larger galactocentric distances over time. We conclude that the formation of exoplanets throughout the Galaxy follows the Galactic chemical evolution, for which our results are in agreement with the observed negative interstellar medium (ISM) metallicity gradient and its enrichment and flattening with time at any radius.
A Highly Sensitive Triple Quad LC–MS/MS Method Development and Validation for the Determination of Bexicaserin (LP352) in Human Plasma and Urine Matrices
Authors: Kallem Raja Reddy , Yeager Maisy , Chan Rosa , Fletcher Katharine , Neal Katie , Srinivas Nuggehally R. 
Published: January 2025

ABSTRACTBexicaserin is a highly selective agonist at the 5‐HT2c receptor in clinical development for the treatment of seizures associated with developmental and epileptic encephalopathies (DEEs). We report an LC–MS/MS method for the quantitative estimation of bexicaserin in human plasma and urine. The sample preparation involves the extraction of bexicaserin and internal standard (13CD2‐bexicaserin; IS) from 150 μL plasma and 50 μL urine using a solid phase extraction method. The chromatographic separation of bexicaserin and IS was achieved on a Poroshell EC‐C18 column using 5 min gradient program. The calibration curve ranged from 0.1 to 100 ng/mL in plasma and 1.0 to 1000 ng/mL in urine. Intraday and interday precision and accuracy, linearity, matrix effect, extraction recovery, carry‐over, dilution integrity, a battery of stability studies, and incurred sample reanalysis were performed for bexicaserin in both plasma and urine. The intraday and interday accuracy and precision were well within the acceptable limits in both plasma and urine matrices. Stability studies in plasma and urine showed that bexicaserin was stable on bench for 24 h, in autosampler over 54 h, five freeze–thaw cycles, and long‐term storage at −20°C and −80°C for > 368 days. The validated methods were successfully applied in clinical study.
X‐ray controlled release strategy in cancer therapy
Authors: Ruan Yiling , Huang Hongxiang , Liu Huihui , Gong Jinglang , Li Changjun , Sun Xiaolian 
Published: January 2025

AbstractConstruction of drug carriers or prodrugs is a common approach to improve the pharmacokinetics of molecular drugs and enhance the tumor curative effect. Nanocarriers that can be activated by the tumor microenvironment including enzymes, pH, redox status, or external stimuli such as ultraviolet, ultrasound, and magnetism, are booming. As a commonly used clinical theranostic approach with excellent spatiotemporal controllability and deep tissue penetration, X‐ray has attracted much attention as an external stimulus in recent years. The rapid development of nanomaterials as radiosensitizers or radioluminescents further accelerates the construction of X‐ray‐responsive nanocarriers. In this review, the currently developed X‐ray activated drug release systems in cancer therapy are summarized with a focus on controlled release design.
Atrial Fibrillation Recurrence Risk After Catheter Ablation in Patients With Rheumatoid Arthritis: A Systematic Review and Meta‐Analysis
Authors: Rujirachun Pongprueth , Wattanachayakul Phuuwadith , Taveeamornrat Svita , Ungprasert Patompong , Tokavanich Nithi , Jongnarangsin Krit 
Published: January 2025

ABSTRACTBackgroundThe association between rheumatoid arthritis (RA) and the risk of developing atrial fibrillation (AF) is well‐established. However, data on the impact of RA on AF recurrence postcatheter ablation (CA) remain unclear. This current study aimed to assess the impact of RA on AF recurrence after catheter‐based pulmonary vein isolation.MethodsPotentially eligible studies were identified from Medline and EMBASE databases from inception to December 20, 2023. Eligible study must consist of two cohorts of patients with and without RA who underwent catheter ablation for AF. Pooled risk ratio (RR) and 95% CI were calculated using Dersimonian and Laird's random‐effect, generic inverse variance approach.ResultsThe meta‐analysis includes three retrospective cohort studies with a total of 700 patients. The pooled analysis found a significantly increased risk of AF recurrence after CA among patients with RA compared to patients without RA with the pooled RR of 1.59 (95% CI, 1.10–2.29, I2 14%). Increased risk of early recurrence (within 90 days) was also observed with the pooled RR of 2.70 (95% CI, 1.74–4.19, I2 0%).ConclusionsThe current study found that patients with RA have a higher risk of AF recurrence after CA for AF, including the risk of early recurrence.
The Association Between IL‐8 Gene Polymorphisms and the Risk of Several Types of Cancer, Especially in Gastric Cancer
Authors: Xu Bin , Yan Yidan 
Published: January 2025

ABSTRACTBackgroundChanges in functional genetic polymorphisms may increase or decrease the risk of cancer in patients. Nowadays, the association between polymorphisms in the interleukin‐8 (IL‐8) gene and the susceptibility of cancer risk have been investigated in many studies, however, above relationships remain unclear.AimThe current study aims to comprehensively evaluate the association between IL‐8 gene six polymorphisms and the whole cancer risk, especially −251 polymorphism and gastric cancer.Methods and ResultsSix polymorphisms (−251, −353, +678, +1633, +2767, +781) were collected. The expression of serum IL‐8 was calculated by ELISA assay. First, 104 case–control studies were conducted. Second, this research has made significant discoveries regarding the −251, −353 and +781 polymorphisms and the potential associations with cancer risk. Finally, the serum IL‐8 levels in gastric cancer patients with AA/TT genotypes were significantly higher than those with the same genotypes of healthy controls and TT genotypes in gastric cancer patients.ConclusionOverall, the investigation has revealed that IL‐8 gene polymorphisms significantly influence vulnerability to cancer development, especially for gastric cancer.
Optimized Execution of a Numerical Weather Forecast Model in a Cloud Cluster
Authors: de Melo Mateus S. , Souto Roberto Pinto , Drummond Lúcia M. A. 
Published: January 2025

ABSTRACTThis study proposes strategies to reduce the financial cost of using cloud clusters, through Amazon Web Services (AWS) ParallelCluster, to run the weather forecast model Brazilian developments on the Regional Atmospheric Modeling System (BRAMS). We developed an instance selection algorithm that obtains and compares the costs of various instance types in different regions and markets, recommending those with the lowest costs. If the suggested instance is a Spot instance and is revoked by the cloud provider, the proposed strategy resumes the application execution from a pre‐recorded checkpoint by rescheduling it on On‐Demand instances. This study also presents a detailed analysis of BRAMS execution across various instance architectures and proposes a novel three‐queue architecture for managing BRAMS execution on On‐Demand and Spot instances within AWS ParallelCluster. The results obtained from small and large spatial domains executed in AWS ParallelCluster using the proposed strategies show that adopting a cloud cluster is a promising alternative for this type of High‐Performance Computing application, compared with execution on a supercomputer.
Vericiguat improves cardiac remodelling and function in rats with doxorubicin‐induced cardiomyopathy
Authors: Chen Wen , Wu Ying , Li Wei , Song Meiyan , Xu Kaizu , Wu Meifang , Lin Liming 
Published: January 2025

AbstractPurposeVericiguat, a soluble guanylate cyclase (sGC) stimulator, has been demonstrated effective in improving prognosis of patients with heart failure with reduced ejection fraction. However, there are limited data concerning the effect of vericiguat in patients with doxorubicin (DOX)‐induced cardiomyopathy (DIC). In this study, we investigated the effects of vericiguat on cardiac structure and function in rats with DIC as well as their potential mechanisms of action.MethodsDIC rats were established by intraperitoneal injection of DOX (1 mg/kg) twice a week for 6 weeks, followed by intragastric administration of vericiguat 1 mg/kg/day or an equal volume of normal saline for 8 weeks. Cardiac histology and function, circulating levels of amino‐terminal pro‐B‐type natriuretic peptide (NT‐proBNP), nitric oxide (NO), and oxidative indices, as well as myocardial cyclic guanosine monophosphate (cGMP)‐protein kinase G (PKG) signalling, oxidative and apoptosis‐associated protein were measured.ResultsCompared with the control group, rats treated with DOX exhibited significantly increased heart size, reduced systolic function and elevated plasma levels of NT‐proBNP. Histological findings revealed myocardial cell atrophy, fibrosis and apoptosis. Vericiguat treatment effectively reversed DOX‐induced cardiac remodelling and improved systolic function. Mechanistically, Vericiguat attenuated the inhibitory effects of DOX on the myocardial cGMP‐PKG axis and nuclear factor erythroid 2‐related factor 2 (Nrf2) protein, thereby alleviating oxidative stress and apoptosis.ConclusionsVericiguat improved cardiac remodelling and contractile function in rats with DIC through upregulation of cGMP‐PKG signalling and inhibition of oxidative stress and myocardial apoptosis.
Oxygen Atom Migration of Allylic Esters via an Organocatalyzed Claisen‐type Rearrangement
Authors: Wang Xiaoli , Liu Ke , Jin Xudong , Li Xin , Shen Mingyu , Zhang Sheng , Li Man‐Bo 
Published: January 2025

AbstractDirect transforming molecular skeleton to the other useful one is highly desirable for synthetic chemists. Oxygen atom migration of allylic esters is a powerful avenue for skeleton editing, and various methodologies involving palladium, Lewis acid and cobalt hydride catalysts have been reported. However, these protocols commonly suffer from inferior functional group tolerance and limited preparative application due to the harsh conditions and metal residues. Herein, we report a practical approach for the transformation by using an organocatalyst 4‐dimethylaminopyridine (DMAP). We test this protocol generality and practicality with uniform gram‐scale reactions, and it tolerates with a broad range of functional groups including boric ester, nitrile, ester and others (42 examples). Moreover, corresponding products exhibit versatile reactivity with a series of nucleophiles to open up a platform for bioactive molecules synthesis. A plausible reaction mechanism is proposed to rationalize the experimental observations.
Discovery and Significance of the Neoproterozoic Gabbro Intrusion in the Bayan Obo Group Along the Northern Margin of the North China Craton
Authors: Hu Hao , Li Yuan , Zhou Zhiguang , Wang Guosheng , Gao Shen , Chen Jianfeng , Feng Chenfei 
Published: January 2025

ABSTRACTThe tectonic position of the North China Craton within the Rodinia supercontinent remain unclear due to the scarcity of early Neoproterozoic magmatic rocks in the region, resulting in limited paleomagnetic data. In this study, we report the discovery of a Neoproterozoic metamorphic gabbro intrusion within the Bayan Obo Group, located in the northwestern Bayan Obo rift zone at the northern margin of the North China Craton. This finding offers crucial geological insights into addressing this key scientific question. We utilised petrography, whole‐rock geochemistry, zircon U–Pb geochronology, and Sr‐Nd isotopic analysis to investigate the genesis and source of the gabbroic rock and its tectonic setting. The metamorphosed gabbro has a zircon 206Pb/238U weighted mean age of 925.9 ± 7.2 Ma, with low SiO2 (46.46%–48.28%), high Na2O (2.95%–3.56%), and low K2O (0.761%–1.41%), and has the signature of sub‐alkaline tholeiitic basalt. It is enriched in large‐ion lithophile elements (Rb, Ba, Th, U, K, Pb) and depleted in high‐field‐strength elements (Nb, Ta). The rock is also enriched in light rare earth elements, shows a negative Eu anomaly, and has a positive εNd(t) value (+0.1 ~ +0.8). The metamorphosed gabbro shares geochemical characteristics and Nd isotopic compositions with contemporaneous mafic intrusions, including the 945–890 Ma mafic sills in southeastern North China Craton, the ~925 Ma Dashigou mafic dike swarm in central North China Craton, the ~925 Ma gabbro in Guyang, northern North China Craton, and the 827–819 Ma gabbro in Langshan, western North China Craton. This age suggests that the gabbro may represent a response to a large‐scale mafic magmatic event in central‐eastern North China Craton during the early Neoproterozoic, potentially linked to the initial breakup of the Rodinia supercontinent.
Holding up the mirror: The role of teacher educators and syllabi in perpetuating or disrupting inequity
Authors: Batz Ruby , Walter Melissa C. , Burnham Melissa M. , Fiore Lisa B. 
Published: January 2025

AbstractThis blended pilot‐empirical and theoretical manuscript documents a reflective journey undertaken by a group of early childhood teacher educators located across different regions of the United States as they examined their course design, materials, and syllabi construction. Grounded in reflective practice, intersectionality, and critical pedagogy, their collaborative endeavor necessitated profound self‐examination and recognition of oppressive structures inherent within the field and reproduced throughout course syllabi, thereby perpetuating societal inequities inside and outside the classroom context. Their iterative, evolving effort resembled a reflective consultation group, marked by continuous self‐reflection, challenging assumptions, and transforming actions, vividly portrayed in their vignettes. A nonlinear spiral model emerged as a visual representation of the multiple entry points into an ongoing process—highlighting access points that encourage curiosity and interrogation of academic syllabi and course content. The inclusive nature of this inquiry invites faculty members and practitioners to confront racism, ableism, and other systems of domination, amplify marginalized scholarship, and redefine early childhood education‐related fields, including the Infant and Early Childhood Mental Health landscape. It also underscores the imperative of sustained introspection and collaborative action in nurturing equity.
Reactive Metabolites Cause Idiosyncratic Drug‐Induced Liver Injury via Inflammasome Activation in Antigen‐Presenting Cells
Authors: Kato Ryuji 
Published: January 2025

ABSTRACTAlthough the pathophysiology of idiosyncratic drug‐induced liver injury (IDILI) is unclear, it is presumed to be immune‐mediated, involving complex interactions between drug metabolism and activation of the immune system. The following four reactive metabolite production patterns are considered: (1) parent compounds into reactive metabolites within neutrophils or antigen‐presenting cells (APCs), (2) reactive metabolites produced by cytochrome P450 (CYP), (3) nonreactive metabolites produced by CYP into reactive metabolites within APCs, and (4) reactive metabolites produced by non‐CYPs. Reactive metabolites indirectly activate inflammasomes in APCs, leading to IDILIs. These metabolites can cause cell damage, resulting in the release of damage‐associated molecular patterns (DAMPs), which subsequently activate APCs. Given the diversity of DAMPs, comprehensive analyses are warranted to identify additional candidates. If validates, these DAMPs could be used as early biomarkers and predictive markers of IDILIs onset.
Achieving High‐Precision Attenuation Coefficient Measurement in Optical Coherence Tomography
Authors: Neubrand Linda B. , Attendu Xavier , van Leeuwen Ton G. 
Published: January 2025

ABSTRACTIn this study, we aim to validate the analytical Cramer‐Rao lower bound (CRLB) equation for determining attenuation coefficients using a 1310 nm Optical Coherence Tomography (OCT) system. Our experimental results successfully confirm the validity of the equation, achieving unprecedented precision with a standard deviation below 0.01 mm−1 for intralipid samples. Furthermore, we introduce a systematic framework for attaining high precision in OCT attenuation measurements.
Statistical Assessment and Augmentation of European Centre for Medium‐Range Weather Forecasts Monthly Precipitation Forecast (SEASonal Prediction of Precipitation)
Authors: Nasseri Mohsen , Schoups Gerrit , Taheri Mercedeh 
Published: January 2025

ABSTRACTAccurate prediction of precipitation is of paramount importance for effective planning of future water resources. In this study, we focused on the improvement and evaluation of the European Centre for Medium‐Range Weather Forecasts (ECMWF) fifth‐generation ensemble‐based seasonal precipitation prediction product, designated (SEASonal prediction of precipitation (SEAS5)). Three selected linear regression methods, namely ordinary least squares (OLS), flexible least squares (FLS) and the quantile‐quantile (Q‐Q) methods, were used to develop a correction procedure. The watershed of Lake Urmia was selected as a case study. The application of these augmentation methods has yielded encouraging results, demonstrating an improvement in the statistical metrics of SEAS5 precipitation forecasts for the first and second‐coming months. However, all linear projection methods improve the performance of the SEAS5 products. The Q‐Q method has shown the highest efficiency among the methods, playing a significant role in improving the accuracy of the hindcast precipitation. A variety of statistics (deterministic, forecast skill and uncertainty scores) were used to evaluate the effectiveness of both the raw and enhanced SEAS5 products. These analyses provide a comprehensive understanding of the performance of the SEAS5 product in its original form and after augmentation. The results highlight the potential of the linear projection method (specifically Q‐Q method) to improve the accuracy of hindcast precipitation and provide valuable insights for water resource planning in the study area.