bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Curious Case of Subacute Meningitis- Eosinophilic meningitis caused by Angiostrongylus cantonensis
Authors: Anandan Somarajan , Rajendran Sajeesh S. , Padmanabhan Rihul 
Published: January 2025

Presence of eosinophils in cerebrospinal fluid (CSF) is a very important clue for the aetiology of meningitis and has to be carefully looked by an experienced pathologist. Most of the time history reveals the origin of eosinophilic meningitis (EM). Angiostrongylus cantonensis is the most common cause of eosinophilic meningitis worldwide. Peripheral eosinophilia and CSF eosinophils can increase in spite of anthelmintics and treatment should include steroids in addition to anthelmintics. Here we describe a case of eosinophilic meningitis following consumption of meat of monitor lizard who presented with headache and diplopia without fever.
Comparative Study of Watertight and Non-Watertight Duraplasty for Decompressive Craniectomy in Traumatic Brain Injury: A Prospective Study
Authors: Shakya Bikram , KC Bidur 
Published: January 2025

Introduction: This prospective study aimed to compare the efficacy and safety of watertight versus non-watertight duraplasty techniques in patients undergoing decompressive craniectomy (DC) for severe traumatic brain injury (TBI).
Material and Methods: We evaluated 48 patients with severe TBI who underwent DC, with 24 receiving watertight duraplasty and 24 receiving non-watertight duraplasty. Primary outcomes included the incidence of cerebrospinal fluid (CSF) leaks, postoperative infections, and wound healing disturbances. Secondary outcomes included operative duration, ICU stay, hospital stay, mortality, and Glasgow Outcome Scale (GOS) scores at 6 months post-surgery. Data were compared using appropriate statistical tests, and results were benchmarked against international publications.
Results: Watertight duraplasty significantly reduced the incidence of CSF leaks (8.3% vs. 29.2%, P=0.041) and shortened hospital stay (22.8 ± 6.3 days vs. 28.4 ± 7.2 days, P=0.027) compared to non-watertight duraplasty. Although the watertight group had fewer postoperative infections (12.5% vs. 25.0%) and wound healing disturbances (8.3% vs. 20.8%), these differences were not statistically significant. The operative duration was longer for the watertight group (145 ± 25 minutes vs. 115 ± 20 minutes, p<0.001). ICU stay (12.5 ± 4.2 days vs. 14.3 ± 5.1 days, P=0.187), mortality rates (8.3% vs. 12.5%, P=0.642), and GOS scores (3.5 ± 1.1 vs. 3.3 ± 1.2, P=0.483) were similar between the groups.
Conclusion: Watertight duraplasty is associated with lower rates of CSF leaks and shorter hospital stays but requires longer operative times. However, the absence of significant differences in infection rates, wound healing, ICU stay, and long-term neurological outcomes indicates the need for further research. The comparison of our results with international publications underscores the global relevance of optimizing duraplasty techniques to improve patient outcomes in neurosurgery.
मलमासस्य विमर्शः
Authors: गौतम Gautam दामोदर Damodar 
Published: January 2025

मस् परिमाणे इत्यस्माद्धातोर्निष्पन्नोऽयं मासशब्दः । मस्यते परिमीयते यावता कालेन चन्द्रस्य वृद्धिक्षययोः स चान्द्रो मासः । चान्द्रमासः शुक्लादिशुक्लपक्षस्य प्रतिपदात आरभ्य दर्शान्तः अमावास्यान्तः एक चान्द्र मासः व्यवह्रियते । चान्द्रमासो विशेषतः आभ्युदयिके पितृकार्येऽन्यव्रतपर्वणि च प्रशस्यते । चान्द्रमासः शुद्धमासः विद्धमासो (मलमास) रूपेण द्विविधो भवति । काम्यकर्मणां प्रारम्भः समाप्तिश्च मलमासे न भवति । मलमासे अन्यानि कर्माण्यपि प्रतिबन्धकीभूतानि दृश्यन्ते । मलमासविषये विभिन्नानि धर्मशास्त्रीयाणि मतमतान्तराणि विद्यन्ते । तेषु ग्रन्थोक्तदिशमवलम्ब्य मलमासस्वरूपं कालः, मलमासः कदा केन कारणेन आयाति ? मलमासे कार्याकार्यकर्म जप-तप-दानादेः फलं प्राप्यते न वा ? देवकार्यं पितृकार्यं च मलमासे कथं क्रियते ? मलमासे विहितं कर्म, निषिद्धं कर्मादिविषये शास्त्रीयं मतमवलम्व्यात्र प्रकाशनं विधीयते ।
Pengaruh Pelatihan dan Disiplin Kerja terhadap Kinerja Karyawan pada Pt Griyaceria Nusamekar di Tanah Abang Jakarta Pusat
Authors: Irvan Irvan 
Published: January 2025

Penelitian ini bertujuan untuk mengetahui pengaruh pelatihan dan disiplin kerja terhadap kinerja karyawan pada PT Griyaceria Nusamekar di Tanah Abang Jakarta Pusat. Metode yang digunakan adalah explanatory research dengan teknik analisis menggunakan analisis statistik dengan pengujian regresi, korelasi, determinasi dan uji hipotesis. Hasil penelitian ini pelatihan berpengaruh signifikan terhadap kinerja karyawan sebesar 47,6%, uji hipotesis diperoleh t hitung > t tabel atau (7,451 > 2,000). Disiplin kerja berpengaruh signifikan terhadap kinerja karyawan sebesar 41,2%, uji hipotesis diperoleh t hitung > t tabel atau (6,538 > 2,000). Pelatihan dan disiplin kerja secara simultan berpengaruh signifikan terhadap kinerja karyawan dengan persamaan regresi Y = 8,563 + 0,422X1 + 0,380X2 dan kontribusi pengaruh sebesar 60,4%, uji hipotesis diperoleh F hitung > F tabel atau (45,837 > 2,760).
Pengaruh Kepemimpinan dan Keselamatan Kesehatan Kerja (K3) terhadap Produktivitas Kerja Karyawan pada CV Artha Mulia Block Kadusirung Tangerang
Authors: Bela Mila Sintia , Rahman Ana Septia 
Published: January 2025

ujuan dari penelitian ini adalah untuk mengetahui pengaruh kepemimpinan dan keselamatan kesehatan kerja (K3) terhadap produktivitas kerja karyawan padak CV Artha Mulia Block Kadusirung Tangerang. Metode penelitian yang digunakan dalam penelitian ini adalah penelitian kuantitatif. Populasi yang digunakan dalam penelitian ini seluruh karyawan CV Artha Mulia Block Kadusirung Tangerang. Metode pengambilan sampel yang digunakan oleh penulis dalam penelitian ini adalah metode sample jenuh, berjumlah 59 karyawan. Metode pengumpulan data yang digunakan dalam penelitian ini adalah data primer dan sekunder. Seluruh hasil dari penelitian ini menunjukan bahwa pada pada uji hipotesis kepemimpinan berpengaruh secara parsial terhadap produktivitas kerja karyawan pada CV Artha Mulia Block Kadusirung Tangerang. Hal ini dibuktikan dengan nilai t hitung > t tabel yaitu 6,598 > 1,672. Hal tersebut juga diperkuat dengan nilai Sig yaitu 0,000 < 0,05. Sedangkan uji hipotesis yang kedua yaitu keselamatan kesehatan kerja (K3) berpengaruh secara parsial terhadap produktivitas kerja karyawan pada CV Artha Mulia Block Kadusirung Tangerang. Hal ini dibuktikan dengan nilai t hitung > t tabel yaitu 2,250 > 1,672. Hal tersebut juga diperkuat dengan nilai Sig yaitu 0,028 < 0,05. Adapun uji yang ketiga kepemimpinan dan keselamatan kesehatan kerja (K3) berpengaruh secara simultan terhadap produktivitas kerja karyawan pada CV Artha Mulia Block Kadusirung Tangerang. Hal ini dibuktikan dengan nilai F hitung > F tabel yaitu 101,311> 3,16. Hal juga diperkuat dengan nilai Sig yaitu 0,000 < 0,05.
Dampak Ibu Bekerja Terhadap Perkembangan Emosional Anak
Authors: Cahyati Nika 
Published: January 2025

Penelitian ini membahas dampak ibu bekerja terhadap perkembangan emosional anak, yang merupakan salah satu aspek penting dalam pertumbuhan anak. Peran ibu sebagai pengasuh utama sering kali menghadapi tantangan ketika harus menyeimbangkan tanggung jawab pekerjaan dan keluarga. Hal ini dapat memengaruhi kualitas waktu yang dihabiskan bersama anak, yang secara langsung maupun tidak langsung berdampak pada perkembangan emosional mereka. Penelitian ini menggunakan pendekatan kualitatif dengan studi literatur, penelitian ini dilakukan pada bulan januari 2024 sampai pada November 2024 di desa Darma Kecamatan Darma Kabupaten Kuningan. Subjek penelitian ini yaitu orangtua pada anak usia 5 tahun sebanyak 10 orang, pada anak yang memiliki orangtua bekerja, khusunya pada ibu yang bekerja. Teknik analisis data berupa wawancara dan angket yang disebar pada orang tua. Hasil kajian menunjukkan bahwa dampak ibu bekerja terhadap anak dapat bersifat positif maupun negatif, tergantung pada berbagai faktor, seperti durasi kerja ibu, dukungan keluarga, kualitas pengasuhan, dan lingkungan sosial anak. Ibu yang bekerja dengan dukungan keluarga yang baik dan pengelolaan waktu yang optimal cenderung mampu memberikan teladan yang positif bagi anak, seperti nilai kemandirian dan kerja keras. Sebaliknya, kurangnya kehadiran emosional dan waktu berkualitas dapat menyebabkan anak merasa kurang perhatian, yang berpotensi mengganggu perkembangan emosional mereka.
Trends and Factors Associated with Insomnia and Sleep Apnea in U.S. Military Aviators, 2006–2022
Authors: Caldwell John A. , Knapik Joseph J. 
Published: January 2025

INTRODUCTION: Insomnia and sleep apnea (SA) can have adverse effects on operating aircraft. This study examined trends in insomnia and SA incidence rates in U.S. military aviators from 2006–2022 and examined associated demographic and operational factors.
METHODS: Data on incidence cases of outpatient insomnia and SA, aviator demographics, and operational factors were obtained from the Defense Medical Epidemiological Database, a comprehensive online archive of military medical data. Insomnia and SA cases were identified using specific International Classification of Diseases codes.
RESULTS: For the entire military aviator population (N = 331,992 ± 1649, mean ± SD) overall rates of insomnia and SA were 10.2 and 24.9 cases/1000 person-years, respectively. Compared to the entire U.S. military nonaviator population, aviators had lower incidence of insomnia, but higher incidence of SA. Insomnia rates among aviators increased up to 2015 and declined afterwards, while SA rate generally rose over the period. Insomnia and SA rates among aviators increased with age, were higher among those of black and other nonwhite races, were highest among Army personnel (compared to other services) and were highest among helicopter pilots (compared to fixed-wing aircraft pilots). Insomnia rates were similar among male and female aviators, but SA rates were higher among men.
DISCUSSION: These data indicate that insomnia and SA are prevalent within the military aviation population; however, the incidence of insomnia appears to have fallen as the tempo of military operations has decreased while the incidence of SA continues on an upward trajectory, possibly associated with the growing problem of obesity.
Caldwell JA, Knapik JJ. Trends and factors associated with insomnia and sleep apnea in U.S. military aviators, 2006–2022. Aerosp Med Hum Perform. 2025; 96(1):23–30.
The Courage of Public Reason: Sergei Alexandrovich Tokarev as a Historiographer
Authors: Solovey Tatyana D. 
Published: January 2025

S. A. Tokarev founded the Russian historiographical tradition, laying the conceptual framework for studying the history of Russian ethnography (its pre-Soviet period), and the origins and history of foreign ethnology. Here we regard historiography in its professional sense and not just as a functional appendage of scientific research. In the author’s interpretation, historiography is not only (and not so much) a narrative about the past, but rather an internal dialogue of science and its self-reflection, a refined form of research into the past and modernity. S. A. Tokarev’s appeal to this genre dates back to the turn of the 1940s–1950s, when a unique constellation of conditions for a successful historiographical search developed. These conditions were rooted both in the internal scientific dynamics (ethnography had acquired a stable status of an independent discipline and a high degree of maturity of professional discourse) and in external circumstances (here the ideological vector coincided with the public sentiment — the struggle against cosmopolitanism on the one hand and the legitimate pride of the victorious people on the other). In this context it was crucial to create a respectable historiographical tradition, which would highlight the significant (and in the Soviet era - the leading) role of Russian science in the global context. The author’s interest is not in the analysis of S. A. Tokarev’s historiographical concept, but rather in the circumstances and conflicts (interdisciplinary, political and ideological) surrounding the preparation and publication of vast historiographical works. The article touches upon the usually neglected topic about scientific preferences and the specifics of a scientist’s research strategy as a projection of his psychotype. Why was it Tokarev who make the historiographical breakthrough? How was the “research laboratory” of a Soviet scientist organized, constrained by the rigid framework of planning, by external (political and ideological) and internal (scientific community) censorship, and under conditions of chronic academic and teaching overload? These issues are of considerable scientific interest.
A clinical decision model for failed adrenal vein sampling in primary aldosteronism
Authors: ter Haar Sophie N. M. , van Goor Sofie J. , Corssmit Eleonora P. M. , van Erkel Arian R. , Ballieux Bartholomeus E. P. B. , Dekkers Olaf M. , Nijhoff Michiel F. 
Published: January 2025

ObjectivePrimary aldosteronism (PA) is a common cause of secondary hypertension with unilateral and bilateral subtypes requiring different treatments. Adrenal vein sampling (AVS) is the gold standard for subtype differentiation but can be unsuccessful by challenging right adrenal vein anatomy. This study aimed to develop a clinical decision model using only measurements from the left adrenal vein (LAV) and peripheral blood (IVC) to differentiate between PA subtypes.MethodsThe retrospective cohort study included 54 PA patients who underwent bilaterally successful AVS. The main objective was to determine optimal cut-off values for the LAV/IVC index, using ROC analysis for subtype prediction. The predictive value of this index was assessed with the Area Under the Curve (AUC). The Youden index calculated cut-off values, targeting a specificity &gt;90% for PA subtype differentiation.ResultsThe cohort, averaging 48.5 ± 9.5 years in age, comprised 21 women and 33 men, among whom 26 presented with unilateral and 28 with bilateral disease. LAV/IVC values &lt;1.2 indicated unilateral right-sided disease (specificity 91%, sensitivity 96%, AUC 0.98, 95% confidence interval (CI) 0.95-1.0), values 1.2-2.4 suggested bilateral disease (sensitivity 93%, specificity 64%, AUC 0.85, CI 0.73-0.96), whereas values ≥4.4 predicted unilateral left-sided disease (specificity 93%, sensitivity 60%, AUC 0.85, CI 0.73-0.96). Published literature aligns with our results on cut-off values.ConclusionsUtilizing the LAV/IVC index, over 70% of unsuccessful AVS procedures due to failed right adrenal cannulation could be interpreted with over 90% certainty regarding the PA subtype, preventing unnecessary resampling and aiding in determining the preferred treatment.
Comparison of Individualized Rescue Luteal Phase Support Strategies with Vaginal and Combined Vaginal & Subcutaneous Progesterone Administration in Artificial Frozen-Thawed Blastocyst Embryo Transfer Cycles Based on Serum Progesterone levels
Authors: Arik Alpcetin Secil Irem , Ince Onur , Akcay Bengisu , Cevher Akdulum Munire Funda , Demirdag Erhan , Erdem Ahmet , Erdem Mehmet 
Published: January 2025

ObjectivesHormone replacement therapy (HRT) frozen embryo transfer (FET) cycles are common in assisted reproductive techniques. As the corpus luteum is absent in these cycles, luteal phase support is provided by administering progesterone (P4) through transvaginal, parenteral, or oral routes. Low serum levels of P4 (below 9-10 ng/mL) on the day before embryo transfer (ET) have been associated with unfavorable cycle outcomes. The aim of this study is to investigate whether individualizing luteal support through rescue protocols in patients with low serum P4 levels improves pregnancy outcomes in HRT-FET cycles.Material and methodThis retrospective, single-center cohort analysis includes 1257 cycles involving 942 patients undergoing HRT-FET. Starting in 2019, we have assessed P4 levels before ET day and adjusted MVP doses when P4 levels were &lt;10 ng/mL. In 2021, subcutaneous (SC) P4 was routinely added alongside MVP, with SC doses increased if P4 levels were &lt;10 ng/mL. In this study, Groups 1 and 2 received MVP for luteal support, while Groups 3 and 4 received additional SC progesterone. For patients with P levels below the cut-off level (10 ng/mL) in Groups 2 and 4, the P dose was doubled through a rescue protocol.ResultsIn the MVP and MVP plus SC groups, 15.8% and 8.9% of the cycles had P4 levels &lt;10 ng/mL, respectively. Ongoing pregnancy rates (OPR) and clinical pregnancy rates (CPR) did not differ between study groups. Regression analysis with a mixed model revealed that age, endometrial thickness, and estradiol levels were confounding factors as well as independent predictors of ongoing pregnancy rates (p&lt;0.05). Pairwise regression analysis revealed no significant differences in pregnancy rates between the groups (p&gt;0.05).ConclusionIndividualizing luteal phase support based on serum P4 levels on the day of ET in FET cycles with HRT may enhance pregnancy outcomes by either doubling the vaginal dose or increasing the SC dose during MVP plus SC administration. The implemented rescue protocol allowed patients with low progesterone levels to achieve pregnancy outcomes similar to those with higher progesterone levels.
Impact of pubertal timing on growth progression and final height in subjects affected by RASopathies
Authors: Tamburrino Federica , Mazzanti Laura , Gibertoni Dino , Schiavariello Concetta , Perri Annamaria , Orlandini Eleonora , Rossi Cesare , Tartaglia Marco , Lanari Marcello , Scarano Emanuela 
Published: January 2025

BackgroundRASopathies, including Noonan syndrome and related disorders, are multisystem conditions caused by mutations in various genes encoding proteins involved in the RAS/MAPK signaling pathway resulting in increased signal flow. They are clinically characterized by failure to thrive, facial dysmorphisms, congenital heart defects, lymphatic malformations, skeletal anomalies, and variable cognitive impairment, with variable prevalence in the different conditions and subtypes. Pubertal development, which affects growth and final height, is often delayed in Noonan syndrome patients, though not universally. This study aimed to evaluate the timing and progression of puberty and its impact on growth and final height in patients with RASopathies.Subjects and methodsA retrospective longitudinal study was conducted involving 103 patients with molecularly confirmed RASopathies. A subgroup of 40 patients who had completed pubertal development was analyzed. Anthropometric, hormonal (FSH, LH, estradiol/testosterone), and radiological data were collected.ResultsAmong the 40 patients who had completed puberty, 75% had a diagnosis of Noonan syndrome. The median age at pubertal onset was 11.8 years in males and 13.2 years in females. Delayed puberty was observed in 27.8% of patients, with a higher incidence in females. Median final height was significantly lower in those with delayed pubertal onset compared to those with normal development (p &lt; 0.01). No significant differences in final height were observed between patients with growth hormone deficiency treated with growth hormone and those who were untreated.ConclusionsDelayed pubertal onset negatively impacts final height in patients with RASopathies, with inadequate pubertal catch-up growth being a common outcome. While most patients initiate puberty spontaneously, careful monitoring of growth and pubertal progression is crucial to optimize therapeutic interventions and improve final height outcomes.
A self-activated and protective module enhances the preclinical performance of allogeneic anti-CD70 CAR-T cells
Authors: Zhang Zhao , Zhao Lianfeng , Huang Tinghui , Chen Zhengliang , Zhao Yaoyao , Liang Junqing , Ao Xudong , Jia Xiaoqiong , Kang Lei , Kong Linghui , Jing Qi , Hu Jianhua , Gu Lili , Pan Feiyan , Hu Zhigang , He Lingfeng , Zhou Muya , Chen Jiannan , Guo Zhigang 
Published: January 2025

IntroductionAllogeneic chimeric antigen receptor T (CAR-T) therapy, also known as universal CAR-T (UCAR-T) therapy, offers broad applicability, high production efficiency, and reduced costs, enabling quicker access for patients. However, clinical application remains limited by challenges such as immune rejection, and issues with potency and durability.MethodsWe first screened a safe and effective anti-CD70 scFv to construct anti-CD70 CAR-T cells. Anti-CD70 UCAR-T cells were then generated by knocking out TRAC, B2M, and HLA-DRA. To address the limitations of UCAR-T therapy, we developed an 'all-in-one' self-activated and protective (SAP) module, integrated into the CAR scaffold. The SAP module consists of the CD47 extracellular domain, a mutant interleukin 7 receptor alpha (IL7Rα) transmembrane domain, and the IL7Rα intracellular domain, designed to protect UCAR-T cells from host immune attacks and enhance their survival. ResultsSAP UCAR-T cells demonstrated significantly reduced immune rejection from the innate immune system, as evidenced by enhanced survival and functionality both in vitro and in vivo. The modified UCAR-T cells exhibited improved persistence, with no observed safety concerns. Furthermore, SAP UCAR-T cells maintained process stability during scale-up production, indicating the potential for large-scale manufacturing.DiscussionOur findings highlight the SAP module as a promising strategy for the preclinical development of anti-CD70 UCAR-T, paving the way for an 'off-the-shelf' cell therapy product.
Plasma proteome fingerprint in kidney diseases
Authors: Nikolsky Kirill S. , Kopylov Arthur T. , Nakhod Valeriya I. , Potoldykova Natalia V. , Enikeev Dmitry V. , Butkova Tatiana V. , Kulikova Liudmila I. , Malsagova Kristina A. , Rudnev Vladimir R. , Petrovskiy Denis V. , Izotov Alexander A. , Kaysheva Anna L. 
Published: January 2025

IntroductionKidney diseases pose a serious healthcare problem because of their high prevalence, worsening of patients’ quality of life, and high mortality. Patients with kidney diseases are often asymptomatic until disease progression starts. Expensive renal replacement therapy options, such as dialysis or kidney transplant, are required for end-stage kidney disease. Early diagnosis of kidney pathology is crucial for slowing down or curbing further damage. This study aimed to analyze the features of the protein composition of blood plasma in patients with the most common kidney pathologies: kidney calculus, kidney cyst, and kidney cancer.MethodsThe study involved 75 subjects. Proteins associated with kidney pathologies (CFB, SERPINA3, HPX, HRG, SERPING1, HBB, ORM2, and CP) were proposed. These proteins are important participants of complement and coagulation cascade activation and lipid metabolism.ResultsThe revealed phosphorylated proteoforms (CFB, C4A/C4B, F2, APOB, TTR, and NRAP) were identified. For them, modification sites were mapped on 3D protein models, and the potential role in formation of complexes with native partner proteins was assessed.DiscussionThe study demonstrates that the selected kidney pathologies have a similar proteomic profile, and patients can be classified into kidney pathology groups with an accuracy of (70–80)%.