bluuebunny/crossref_metadata_2025_split huggingface dataset:
Accelerating gender and sexuality inclusion in organisations: Introduction to the special issue and academic agenda
Authors: Sojo Victor E , Wheeler Melissa A , Ryan Michelle K 
Published: June 2023

Gender identity, sexual characteristics and sexual orientation are fundamental dimensions of human life, and we must understand how they relate to organisational and work processes to address workplace inclusion. This special issue was conceived to showcase contemporary research about approaches to accelerate gender and sexuality inclusion in organisations. Here, we introduce the five papers included in this special issue – outlining their logic, variety of methods and contributions. Then we present an agenda of academic work across research, teaching and leadership to further our knowledge of what works and facilitate the translation of that knowledge into inclusive organisational practice. JEL Classification: M14, M12, J16, D23, O15
The performance of carboxylated alginic acid derivatives via methyl orange and Congo red catalytic reduction
Authors: Althomali Raed H , Alamry Khalid A , Alosaimi Abeer M , Hussein Mahmoud A 
Published: June 2023

Numerous water-treatment marital have been developed during the past few years, including adsorbents., the catalytic reduction behavior of carboxylated alginic acid derivatives has been investigated against harmful organic dyes including Methyl Orange (MO) and Congo Red (CR). Alginic acid was firstly oxidized through an easy addition of KMnO4 as an oxidizing agent. A carboxylated alginic acid (CAA) has been interacted with selected metal ions (Sn, Fe, Ni, and Zr) through coordination bonds at the value of pH = 4 to form the corresponding metal complexes namely: Sn-CAA, Fe-CAA, Ni-CAA, and Zr-CAA. The consistency of the coordination was confirmed by several spectroscopic techniques including FT-IR, XRD, SEM, and EDX. The catalytic reduction of these metal ion-based products was carried out against MO, and CR in the presence of NaBH4 as a reducing agent under UV irradiation. All catalysts-based metal complexes showed enhanced catalytic reduction against CR compared to MO. Among all those mentioned metal complexes Sn-CAA showed the best catalytic reduction of these dyes. The time is taken by the Sn-CAA for CR, and MO is 5 and 7 min respectively. Ni-CAA was classified as the second efficient product against both dyes, where the reduction process took 20 and 9 min respectively. The other two catalysts took a long time for CR and MO reduction. Zr-CAA showed more than 80% reduction of only CR dye within 20 min. Whereas, Fe-CAA did not show any significant sign of reduction against both the dyes after the same time. The order of higher catalytic reduction was illustrated as: Sn-CAA > Ni-CAA > Zr-CAA = Fe-CAA.
Functional Outcomes After High-Energy Lisfranc Injuries
Authors: Sinkler Margaret A. , Benedick Alex , Kavanagh Michael , Vallier Heather A. 
Published: June 2023

Background: Midfoot fractures and dislocations are infrequent and functional outcomes following Lisfranc injuries have not been well described. The purpose of this project was to explore functional outcomes following operative treatment of high-energy Lisfranc injury. Methods: A retrospective cohort of 46 adults with tarsometatarsal fractures and dislocations treated at a single Level 1 trauma center were reviewed. Demographic, medical, social, and injury features of these patients and their injuries were recorded. Foot Function Index (FFI) and Short Musculoskeletal Function Assessment (SMFA) surveys were collected after mean 8.7 years’ follow-up. Multiple linear regression was performed to identify independent predictors of outcome. Results: Forty-six patients with mean age 39.7 years completed functional outcome surveys. Mean SMFA scores were 29.3 (dysfunction) and 32.6 (bothersome). Mean FFI scores were 43.1 (pain), 43.0 (disability), and 21.7 (activity), with a mean total score of 35.9. FFI pain scores were worse than published values for fractures of the plafond (33, P = .04), distal tibia (33, P = .04), and talus (25.3, P = .001). Lisfranc injury patients reported worse disability (43.0 vs 29, P = .008) and total FFI scores (35.9 vs 26, P = .02) compared with distal tibia fractures. Tobacco smoking was an independent predictor of worse FFI ( P < .05) and SMFA emotion and bothersome scores ( P < .04). Chronic renal disease was a predictor of worse FFI disability ( P = .04) and SMFA subcategory scores ( P < .04). Male sex was associated with better scores in all SMFA categories ( P < .04). Age, obesity, or open injury did not affect functional outcomes. Conclusion: Patients reported worse pain by FFI after Lisfranc injury compared to other injuries about the foot and ankle. Tobacco smoking, female sex, and preexisting chronic renal disease are predictive of worse functional outcome scores, warranting further study in a larger sample, as well as counseling of long-term consequences of this injury. Level of Evidence: Level IV, retrospective, prognostic.
Risks Associated With Undiagnosed ADHD and/or Autism: A Mixed-Method Systematic Review
Authors: French Blandine , Daley David , Groom Madeleine , Cassidy Sarah 
Published: June 2023

Background: The two most prevalent neurodevelopmental disorders—Attention Deficit Hyperactivity Disorder (ADHD) and Autism (ASD)—(ASD/ADHD) strongly impact individuals’ functions. This is worsened when individuals are undiagnosed and risks such as increased imprisonments, depression or drug misuse are often observed. This systematic review synthesizes the risks associated with late/undiagnosed ASD/ADHD. Methods: Four databases were searched (Medline, Scopus, PsychInfor, and Embase). Published studies exploring the impact of undiagnosed ASD/ADHD were included. Exclusion criteria included, lack of diagnosis status, studies not solely on ASD or ADHD, gray literature and studies not in English. The findings were summarize through a narrative synthesis. Results: Seventeen studies were identified, 14 on ADHD and three on ASD. The narrative synthesis identified three main themes: (1) Health, (2) Offending behavior, and (3) Day-to-day impact. The risks highlighted a significant impact on mental wellbeing and social interactions, higher risks of substance abuse, accidents and offending behavior as well as lower levels of income and education. Discussion: The findings suggest that undiagnosed ASD/ADHD is linked to many risks and negative outcomes affecting individuals, their families, and the wider society. The restricted number of studies on ASD are a limitation to the generalization of these findings Implications for research and practice are discussed, highlighting the importance of screening and acknowledging the possibility of ASD/ADHD in many settings such as psychiatric and forensic.
Exploring the Understanding of Globalization: A Qualitative Study of the Urban, Educated, Middle-Class, Young Indians
Authors: Kapoor Bhumika , Sondhi Vanita 
Published: June 2023

The discipline of psychology is increasingly recognizing the pervasive impact of the ever-changing socio-cultural contexts in which people are embedded. This dynamic nature of the social world is immensely impacted by globalization. As a phenomenon of psychological interest, globalization wields numerous changes across different domains and appears to continuously shape the contours of people’s experiences. Keeping this in mind, exploring people’s perceptions and understanding of globalization can serve as a good starting point to discover its diverse implications. Thus, this research focused on the experiences of urban, educated, middle-class, young people from the metropolitan context of Delhi-NCR, India. To this end, semi-structured interviews were conducted with 32 participants (M = 14, F = 18) between the ages of 18 to 28 years. Data were subjected to reflexive thematic analysis, using inductive coding. Emergent themes and subthemes, related to participants’ notions about globalization and its resultant socio-cultural changes along with their implications are thoroughly discussed.
Exploring the suppression mechanism of wind buffeting noise with bionic structures featuring leading-edge serrations and surface ridges
Authors: Cao Sishi , Zhang Zhifei , Wu Xiong , He Yansong , Zhang Quanzhou 
Published: June 2023

The aim of this study is to investigate the effectiveness and mechanism of wind buffeting noise suppression using a new bionic structure inspired by the quiet flight of owls. Firstly, the new bionic schemes based on NACA0012 wing with two sinusoidal leading-edge serrations and one straight leading-edge curve are used in a cavity after verifying the simulation. Then, the results of the three bionic schemes are compared and analyzed. It is found that the schemes with leading-edge serrations and surface ridges can suppress wind buffeting noise effectively. In particular, the sinusoidal scheme with a wavelength λ = 0.24 c (chord length c) can significantly reduce resonance energies above 21 dB over a wide range of speeds. Furthermore, the study reveals that in the bionic scheme, only the negative pressure core moves in the opening and hits the trailing edge, which reduces the pressure fluctuation in the cavity. The boundary layer thickness (BLT) also fluctuates in span under the influence of the leading-edge serration and the surface ridge, which is favorable for suppressing wind buffeting noise. However, the suppression effect is not solely related to the fluctuation of BLT in the span at the trailing edge but is also influenced by the minimum BLT at this point. Therefore, if the BLT has a certain intensity fluctuation in the span, and the minimum BLT at the trailing edge is close to that of the smooth airfoil scheme, the noise suppression effect is significant.
Accuracy of conventional versus cone-beam CT-synthesised lateral cephalograms for cephalometric analysis: A systematic review
Authors: Raj Grace , Raj Mary , Saigo Leonardo 
Published: June 2023

Objective: To assess the accuracy of cone-beam computed tomography (CBCT)-synthesised lateral cephalograms (CSLCs) compared with conventional lateral cephalograms for cephalometric analysis in human participants and skull models. Methods: The authors performed a search of PubMed, Scopus, Google Scholar and Embase databases on 4 October 2021. Included studies met the following criteria: published in English; compared conventional lateral cephalograms and CSLCs; assessed hard- and soft-tissue landmarks; and were performed on human or skull models. Data extraction from eligible studies was performed by two independent reviewers. The quality of evidence was assessed using the Joanna Briggs Institute (JBI) Critical Appraisal Checklist tool – diagnostic accuracy studies. Results: A total of 20 eligible articles were included in this systematic review. Of these 20 studies, 17 presented with a low risk of bias, while three were found to have a moderate risk of bias. Hard- and soft-tissue analyses were evaluated for each imaging modality. The findings reveal that CSLCs are accurate and comparable to conventional lateral cephalograms for cephalometric analysis and demonstrate good inter-observer reliability. Four studies reported a higher accuracy with CSLCs. Conclusion: Overall, the diagnostic accuracy and reproducibility of CSLCs were comparable to conventional lateral cephalograms in cephalometric analysis. It is justified that patients who have an existing CBCT scan do not need an additional lateral cephalogram, minimising unnecessary radiation exposure, expenses and time for the patient. Larger voxel sizes and low-dose CBCT protocols can be considered to minimise radiation exposure. Registration: This study was registered with PROSPERO (CRD42021282019).
Connecting Today: Feasibility and acceptability of a remote visiting program for people living with dementia in long-term care homes
Authors: O’Rourke Hannah M , Swindle Jennifer , Chacinski Dorothy , Dal Pizzol Fernanda Laís Fengler , Lee Heunjung , Hoben Matthias , Hopper Tammy , McGilton Katherine S , Boscart Veronique 
Published: June 2023

Objectives Social isolation and loneliness affect the quality of life of people living with dementia, yet few interventions have been developed for this population. The purpose of this study was to assess the feasibility and acceptability of ‘Connecting Today’, a remote visiting program designed for use with care home residents living with dementia. Methods This was a feasibility study to assess whether Connecting Today can be delivered in care homes, and was acceptable to family and friends and people living with dementia. We used a single-group before/after design and included residents ≥ 65 years old with a dementia diagnosis from two care homes in Alberta, Canada. Connecting Today involved up to 60 min per week of facilitated remote visits for 6 weeks. To understand feasibility, we assessed rates and reasons for non-enrollment, withdrawal and missing data. We assessed acceptability with the Observed Emotion Rating Scale (residents) and a Treatment Perception and Preferences Questionnaire (family and friends). Data were analyzed with descriptive statistics. Results Of 122 eligible residents, 19.7% ( n = 24) enrolled (mean age = 87.9 years, 70.8% females). Three residents withdrew from the study before the first week of calls. Among 21 remaining residents, 62%–90% completed at least 1 call each week. All the calls were completed by videoconference, rather than by phone. Alertness and pleasure were observed for ≥92% of residents during calls. The 24 contacts rated Connecting Today as logical, effective and low risk. Conclusions Facilitated, remote visits are feasible and highly acceptable to residents and their family and friend contacts. Connecting Today shows promise to address social isolation and loneliness for people living with moderate to severe dementia because it can promote positive engagement in meaningful interactions with their family and friends while they are living in a care home. Future studies will test effectiveness of Connecting Today in a large sample.
Immuno-Biochemical Impacts of Gamma Irradiation in Male Rats: A Dose-Response Study
Authors: Hussien Soha M. , Rashed Engy R. 
Published: June 2023

During radiotherapy, immune-modulatory effects of radiation doses should be taken into consideration, not only the anti-tumor radiation effects. Thus, our study aimed to study how γ-radiation modulates immune response in comparison to common immune-suppressive/stimulant agents. Animals were divided into two groups. Category A received Echinacea purpura extract (EP) or irradiated at low radiation doses 0, .25 or .5 Gray (Gy), whereas Category B received cyclophosphamide (CP) or irradiated at high radiation doses 1, 2, or 5 Gy. Serum levels of immunological mediators interleukin-10 (IL-10) and tumor necrosis factor (TNF-α), as well as redox-markers malondialdehyde (MDA) and nitric oxide (NO), hemoglobin (Hgb), white and red blood cells (WBCs, RBCs), and platelet counts were assessed following irradiation. Of the immune-stimulant category, .25 Gy dose offered EP-comparable effects in TNF-α, RBCs, Hgb, and platelet counts cases. As for the immune-suppressive category; 5 Gy irradiation dose induced inflammatory/immunosuppressive responses indicated (rise in NO, TNF-α, and IL-10), and an oxidative stress status (increase in serum MDA). However, 5 Gy γ-irradiation was not observed, herein, as a single immunosuppressive agent. To conclude, during radiotherapy, immunological impact(s) of the used radiation doses should be optimized and followed-up closely to assess the risk/benefit of their usage.
Oxaliplatin prior to PARP inhibitor in BRCA-mutated ovarian cancer
Authors: Nicoletto Maria Ornella , Baldoni Alessandra , Cavallin Francesco , Grego Andrea , Falci Cristina , Nardin Margherita , Mammano Enzo , Lai Eleonora , Torri Valter 
Published: June 2023

Background: The use of PARP inhibitor (PARPi) has shown a considerable benefit in progression-free survival (PFS) in relapsed, platinum-sensitive epithelial ovarian cancer (OC). Objective: Our study aimed to investigate the impact of the last platinum-based chemotherapy treatment in response to PARPi. Design: Retrospective cohort study. Patients and methods: The study involved 96 consecutive, pretreated, platinum-sensitive advanced OC patients. Demographics and clinical data were retrieved from clinical records. PFS and overall survival (OS) were calculated from the start of PARPi. Results: Germline BRCA mutation was investigated in all cases. Platinum-based chemotherapy before PARPi maintenance therapy included pegylated liposomal doxorubicin-oxaliplatin (PLD-Ox) in 46 patients (48%) and other platinum-based chemotherapy in 50 patients (52%). During a median follow-up of 22 months from the beginning of PARPi therapy, 57 patients relapsed (median PFS: 12 months) and 64 patients died (median OS: 23 months). During multivariable analysis, receiving PLD-Ox before PARPi was associated with improved PFS [hazard ratio (HR): 0.46, 95% CI: 0.26–0.82] and OS (HR: 0.48, 95% CI: 0.27–0.83). In 36 BRCA-mutated patients, PLD-Ox was associated with improved PFS (2-year PFS: 70.0% versus 25.0%, p = 0.02). Conclusion: Receiving PLD-Ox before PARPi may improve prognosis in platinum-sensitive advanced OC patients and may provide advantages in the BRCA-mutated subgroup.
Real-world outcomes among patients with metastatic colorectal cancer treated first line with a bevacizumab biosimilar (bevacizumab-awwb)
Authors: Jin Ran , Ogbomo Adesuwa S. , Accortt Neil A. , Lal Lincy S. , Bishi Geetanjali , Sandschafer Darcie , Goldschmidt Jerome H. 
Published: June 2023

Background: Bevacizumab-awwb (MVASI®) was the first U.S. Food and Drug Administration-approved biosimilar to Avastin® (reference product [RP]) for the treatment of several different types of cancers, including metastatic colorectal cancer (mCRC), an indication approved based on extrapolation. Objectives: Evaluate treatment outcomes in mCRC patients who received first-line (1L) bevacizumab-awwb at treatment initiation or as continuing bevacizumab therapy (switched from RP). Design: A retrospective chart review study. Methods: Adult patients who had a confirmed diagnosis of mCRC (initial presentation of CRC on or after 01 January 2018) and initiated 1L bevacizumab-awwb between 19 July 2019 and 30 April 2020 were identified from the ConcertAI Oncology Dataset. A chart review was conducted to evaluate patient baseline clinical characteristics and effectiveness and tolerability outcomes during the follow-up. Study measures were reported stratified by prior use of RP: (1) naïve patients and (2) switchers (patients who switched to bevacizumab-awwb from RP without advancing the line of therapy). Results: At the end of study period, naïve patients ( n = 129) had a median 1L progression-free survival (PFS) of 8.6 months [95% confidence interval (CI), 7.6–9.9] and a 12-month overall survival (OS) probability of 71.4% (95% CI, 61.0–79.5%). Switchers ( n = 105) had a median 1L PFS of 14.1 months (95% CI, 12.1–15.8) and a 12-month OS probability of 87.6% (95% CI, 79.1–92.8%). During treatment with bevacizumab-awwb, 20 events of interest (EOIs) were reported in 18 naïve patients (14.0%) and 4 EOIs reported in 4 switchers (3.8%), of which the most commonly reported events were thromboembolic and hemorrhagic events. Most EOIs resulted in emergency department visit and/or treatment hold/discontinuation/switch. None of the EOIs resulted in death. Conclusion: In this real-world cohort of mCRC patients who were treated 1L with a bevacizumab biosimilar (bevacizumab-awwb), the clinical effectiveness and tolerability data were as expected and consistent with previously published findings from real-world studies of bevacizumab RP in mCRC patients.
Multidisciplinary Approach to Sedation and Early Mobility of Intubated Critically Ill Neurologic Patients Improves Mobility at Discharge
Authors: Barra Megan E. , Iracheta Christine , Tolland Joseph , Jehle Johnathan , Minova Ljubica , Li Karen , Amatangelo Mary , Krause Patricia , Batra Ayush , Vaitkevicius Henrikas 
Published: June 2023

Background and Purpose Over-sedation may confound neurologic assessment in critically ill neurologic patients and prolong duration of mechanical ventilation (MV). Decreased sedative use may facilitate early functional independence when combined with early mobility. The objective of this study was to evaluate the impact of a stepwise, multidisciplinary analgesia-first sedation pathway and early mobility protocol on medication use and mobility in the neuroscience intensive care unit (ICU). Methods We performed a single-center prospective cohort study with adult patients admitted to a neuroscience ICU between March and June 2016-2018 who required MV for greater than 48 hours. Patients were included from three separate phases of the study: Phase I – historical controls (2016); Phase II – analgesia-first pathway (2017); Phase III – early mobility protocol (2018). Primary outcomes included propofol requirements during MV, total rehabilitation therapy provided, and functional mobility during ICU admission. Results 156 patients were included in the analysis. Decreasing propofol exposure was observed during Phase I, II, and III (median 2243.7 mg/day vs 2065.6 mg/day vs 1360.8 mg/day, respectively; P = .04 between Phase I and III). Early mobility was provided in 59.7%, 40%, and 81.6% of patients while admitted to the ICU in Phase I, II, and III, respectively (P < .01). An increased proportion of patients in Phase III were walking or ambulating at ICU discharge (26.7%; 8/30) compared to Phase I (7.9%, 3/38, P = .05). Conclusions An interdisciplinary approach with an analgesia-first sedation pathway with early mobility protocol was associated with less sedative use, increased rehabilitation therapy, and improved functional mobility status at ICU discharge.