bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical utility of urinary comprehensive genomic profiling in diagnosing metachronous upper tract urothelial carcinoma: a case report
Authors: Yonover Paul M. , Ward Ceressa T. , Mazzarella Brian C. , Phillips Kevin G. , Jensen Brad W. , Bicocca Vincent T. , Duffy Kathleen , Yonover Jaden , Cherry Ava , Levin Trevor G. 
Published: August 2023

Introduction and aim of studyMetachronous upper tract urothelial carcinoma (UTUC) is a rare yet aggressive malignancy that is often multifocal and invasive at the time of diagnosis. Unfortunately, the rarity of metachronous UTUC results in a paucity of targeted data, as current literature and clinical management of this tumor is largely extrapolated from that of bladder cancer. Urinary comprehensive genomic profiling with the UroAmp assay identifies six general classes of tumor-mutations present in the urine and thus, may aid in detecting UTUC when the limitations of current tools impede definitive diagnosis. We describe the utility of urinary comprehensive genomic profiling in confirming the provider’s suspicion for metachronous UTUC and recommending radical nephroureterectomy.Patient caseA 68-year-old male with a history of recurrent carcinoma in situ (CIS) of the bladder presented to the urology clinic in 2022 for continued surveillance. Abnormal soft tissue thickening surrounding the proximal right ureter, revealed on computerized tomography urography, prompted further evaluation. Selective right upper tract cytology was indeterminate, and urinary comprehensive genomic profiling was ordered to adjudicate. No tumor was visualized on ureteroscopy however the cytologic brush biopsy of the renal pelvis and proximal ureter were positive for urothelial carcinoma (UC) and/or CIS. UroAmp testing identified genomic features associated with high-grade UC, risk of invasion, and a high genomic disease burden.ResultsThe patient underwent a right kidney and ureter nephroureterectomy in September 2022. Surgical pathology confirmed non-invasive multifocal urothelial CIS. A postoperative urinary comprehensive genomic profiling in February and May of 2023 detected no evidence of residual disease, consistent with complete resection of the tumor. The provider will continue intensive urinary comprehensive genomic profile monitoring coupled with conventional surveillance.ConclusionUrinary measurement of mutated UC genes correlate with disease burden, pathologic grade, and invasion risk and provide clinical utility when reliance on visual confirmation and cytology were not definitive or feasible.
Increased dietary vitamin D was associated with increased circulating vitamin D with no observable adverse effects in adult dogs
Authors: Jewell Dennis E. , Panickar Kiran S. 
Published: August 2023

IntroductionThere is no consensus for the optimum concentration of vitamin D, although a minimum concentration of 100 ng/mL (250 nM) of circulating vitamin D, measured as 25(OH) D, has been suggested in order to support optimal health in dogs. Few studies have examined the relationship between dietary vitamin D3 (cholecalciferol) intake and the resulting concentrations of circulating 25(OH) D in adult dogs. Recommendations for dog foods for adult maintenance report a safe upper limit of 3,200 IU vitamin D/kg on a dry matter basis. However, these recommendations were not based on studies of adult maintenance requirements. Understanding the relationship between dietary vitamin D and circulating vitamin D is necessary to utilize dietary vitamin D to influence health in dogs.MethodsFive groups of adult dogs (each n = 8) were fed food of approximately 4,000 kcal/kg containing one of the following dry matter concentrations of vitamin D for 6 months: 795.7, 3087.3, 5510.9, 7314.0, and 9992.5 IU/kg. Body weight was recorded at baseline and measured weekly, and daily food intake was recorded. Blood samples were taken at baseline and at the end of the 26-week study period.ResultsThere were no clinical signs of vitamin D deficiency or excess. Serum concentrations of creatinine, blood urea nitrogen, albumin, hematocrit, hemoglobin, alkaline phosphatase, phosphorus, total calcium, ionized calcium, and parathyroid hormone were maintained within reference values in all groups. Circulating 25(OH) D increased in all groups except those that consumed food with 795.7 IU/kg vitamin D, and increased in a linear and quadratic fashion in response to dietary vitamin D concentration. All of the dogs fed food with 5510.9 IU/kg vitamin D or above met or exceeded 100 ng/mL (250 nM) circulating 25(OH) D.DiscussionDietary vitamin D was positively associated with increased circulating concentrations in concentrations up to 9992.5 IU/kg dry matter, with no observable adverse effects. Consumption of ≥5510.9 IU/kg vitamin D resulted in all dogs with at least the 100 ng/mL (250 nM) circulating concentration.
Whole Genome Sequencing and Molecular Epidemiology of Clinical Isolates of Staphylococcus aureus from Algeria
Authors: Namoune Rachida , Djebbar Abla , Mekler Rebecca , McHugh Martin , Bekara Mohammed El Amine , Decano Arun , Holden Matthew T. G. , Sebaihia Mohammed 
Published: August 2023

Staphylococcus aureus is an important pathogen responsible for various healthcare- and community-acquired infections. In this study, whole genome sequencing (WGS) was used to genotype S. aureus clinical isolates from two hospitals in Algeria and to characterize their genetic determinants of antimicrobial resistance. Seventeen S. aureus isolates were included in this study. WGS, single-nucleotide polymorphism (SNP)-based phylogenetic analysis, in silico multilocus sequence typing (MLST), spa and staphylococcal cassette chromosome mec (SCCmec) typing and in silico antimicrobial resistance profiling were performed. Phenotypic antibiotic susceptibility testing was performed using the Vitek 2 system and the disk diffusion method. The isolates were separated into sequence types (STs), with ST80 being predominant; five clonal complexes (CCs); four spa types (t044, t127, t368, t386); and two SCCmec types (IVc and IVa). Whole genome analysis revealed the presence of the resistance genes mecA, blaZ, ermC, fusB, fusC, tetK, aph(3′)-IIIa and aad(6) and mutations conferring resistance in the genes parC and fusA. The rate of multidrug resistance (MDR) was 64%. This work provides a high-resolution characterization of methicillin-resistant S. aureus (MRSA) and methicillin-susceptible S. aureus (MSSA) isolates and emphasizes the importance of continuous surveillance to monitor the spread of S. aureus in healthcare settings in the country.
ANIKI-BÓBÓ E VÍTIMAS DA TORMENTA: A TESSITURA DA NULIFICAÇÃO REPRESENTADA EM IMAGENS
Authors: Osanan Amorim Lima1 Frederico 
Published: August 2023

Este estudo parte do pressuposto de que as imagens cinematográficas podem funcionar como repositórios de informações históricas sobre os processos de nulificação. Nesse prisma, esta pesquisa recorre a dois aspectos: às maneiras como o cinema representou as formas de sujeição na primeira metade do século XX e à forma como, diante dos diversos desenhos de transgressões sociais, as imagens denunciaram, ainda que implicitamente, os meandros do poder disciplinar. Empiricamente,recorro a dois filmes europeus dos anos 1940, Aniki-bóbó (1942), do português Manoel de Oliveira e Vítimas da Tormenta (1946), do diretor e ator italiano Vittorio De Sicca. De um ponto de vista conceitual, dialogo com a produção filosófica e historiográfica do francês Michel Foucault. Os filmes, postos em situações convergentes e descontínuas, acabam por revelar que, a cada nova condição histórica, os saberes sobre a disciplina e os procedimentos de sujeição se modificam.
Comparative Study of One Way and Two Way Communication Da'wah in the Religious Development of Mosque Youth
Authors: Juwita Juwita , Qadaruddin Muhammad , Sulvinajayanti Sulvinajayanti 
Published: August 2023

Penelitian ini menggunakan metode pendekatan deskriptif kualitatif. Teknik yang digunakan berupa teknik pengumpulan data yaitu observasi, wawancara, dandokumentasi. Hasil Penelitian menunjukkan bahwa problematika dakwah one way and two way communiccation bagi seorang Da’i akan mengalami problem-problem ketika menyampaikan dakwah baik dakwah one way and two way communication seperti hambatan semantik, hambatan psikologis, dan hambatan sosiantropologis. Dalam perbandingan efektifitas antara dakwah one way dan dakwah two way keduanya sudah bagus. Hanya saja yang lebih efektif itu dakwah dua arah dikarenakan sudah terbukti melalui kegiatan tersebut remaja sudah mulai percaya diri pada saat mengutarakan pendapatnya ketika diskusi sedang berlangsung
Satire Content Youtube’s Got Talent Channel Skinny Indonesia24 Perspektif Etika Dan Komunikasi Islam
Authors: Saukani Muhammad Saukani , Sulvina Jayanti  , Afidatul Asmar  
Published: August 2023

Kebebasan dalam mengunggah konten youtube menjadi salah satu sebab menurunnya kualitas konten. Fenomena ini dikritik oleh skinnyindonesia24 dengan membuat konten youtube’s got talent untuk mengkritik konten-konten youtube yang dianggap menurunkan standar konten kreator youtube. Tujuan penelitian ini untuk mengkaji makna dan mengetahui satire perspektif etika dan komunikasi Islam pada youtube’s got talent. Penelitian ini menggunakan analisis wacana deskriptif dengan menganalisis ketiga part konten youtube’s got talent untuk mendapatkan data penelitian. Teknik pengumpulan data pada penelitian ini dilakukan melalui tahap observasi dengan menonton secara berulang kali dan dokumentasi dengan mengambil screenshoot suasana serta dialog yang relevan dengan penelitian ini. Hasil penelitian ini menunjukkan satire halus dan satire keras yang digunakan bermakna kritikan kepada konten youtube yang dianggap menurunkan standar konten creator. Pada konten ini juga terdapat beberapa dialog yang tidak sesuai dengan etika komunikasi seperti sifat, tindakan, moral dan relasi. Beberapa dialog juga keluar dari kaidah prinsip komunikasi Islam.
MANAJEMEN ZAKAT BAZNAS
Authors: Adi Asriadi Arifin , Dian Novianti  , Trian Fisman Adisaputra  
Published: August 2023

Tujuan penelitian ini adalah untuk menelaah perencanaan pengelolaan zakat di BAZNAS Barru, pengorganisasian zakat di BAZNAS Barru, pelaksanaan pengelolaan zakat di BAZNAS Barru dan bentuk pengawasan pengelolaan zakat di BAZNAS Barru. Jenis penelitian ini adalah deskriptif kualitatif dengan pendekatan etnografi, yakni sebuah pendekatan penelitian yang mencakup studi intensif budaya manajerial dalam lingkup internal BAZNAS Barru. Data primer dalam penelitian ini yakni hasil dokumentasi pada Website Resmi BAZNAS Barru yang didukung oleh hasil wawancara anggota LAB BAZNAS Barru, sedangkan data sekunder diperoleh dari sumber bacaan relevan. Instrumen penelitian berupa daftar wawancara, dengan teknik pengumpulan data berupa wawancara, observasi dan dokumentasi. Teknik analisis data berupa reduksi data (data reduction), penyajian data (data display), penarikan kesimpulan (conclution) atau verifikasi. Pengujian keabsahan data dilakukan dengan perpanjangan pengamatan, triangulasi dan diskusi. Hasil penelitian menunjukkan: 1) Perencanaan zakat pada BAZNAS Barru yakni dengan menyusun program zakat untuk membangun kesejahteraan ekonomi, peningkatan inteligensi dan keterampilan, jaminan kesehatan, program kepedulian dan peningkatan ketakwaan masyarakat Barru. 2) Pengorganisasian pengelolaan zakat yakni dengan membentuk tim Layanan Aktif BAZNAS (LAB) untuk mendistribusikan zakat dan Unit Pengumpul Zakat (UPZ) untuk menghimpun zakat. 3) Pelaksanaan pengelolaan zakat sesuai dengan perencanaan. 4) Pengawasan pengelolaan zakat dilakukan oleh audit Internal.
Developing a calibration method for heat networks and validating using measured data
Authors: Maldonado Diana , Schönfeldt Patrik , Torio Herena , Witte Francesco , Füting Michael 
Published: August 2023

<p>Fourth and fifth generation district heating (DH) systems have emerged as major contributors to decarbonise the heat sector. However, questions arise about the future trajectory of their existing older versions, which operate at relatively high temperatures. The transformation pathways and operation of DH networks require accurate but simple models to enable rapid simulation. This paper proposes a method for modelling a steady-state DH network using an open-source tool (TESPy) that numerically solves the system of equations and provides a high degree of flexibility in topology and parameterisation. Furthermore, a calibration method using 12 hours of measured data is proposed, which considers the aggregated heat conduction as the calibration parameter and solves the optimisation problem by reducing the difference between the simulated and measured temperature. A DH system in southern Germany with a 15 minute time resolution dataset for the months of January to March 2022 was used as a case study to validate both methods. For the uncalibrated model, the mean absolute error of feed temperatures at all consumers varies from 0.03 °C to 2.34 °C. After calibration, TESPy was found to obtain a mean absolute temperature error of 0.02 °C to 0.5 ◦°C, excluding the cases with high data uncertainty. The accuracy of the simulated temperature enhanced significantly after calibration, thus validating the proposed model. Additionally, it was also observed that the simulated system is more accurate at rather high mass flow conditions. </p>
Detection and Classification of ChatGPT Generated Contents Using Deep Transformer Models
Authors: Maktab Dar Oghaz Mahdi , Dhame Kshipra , Singaram Gayathri , Babu Saheer Lakshmi 
Published: August 2023

<p> The scope of this manuscript covers the use of machine learning and deep learning models to detect and classify AI-generated text, with a particular focus on maintaining academic integrity in computer science. It also includes the creation and public release of a dataset comprising human and AI-generated content. The work also compares these models with existing solutions like Turnitin's AI plagiarism detector, contributing to a robust baseline for identifying AI-generated content in academia. </p>
UPAYA GURU DALAM MENGOPTIMALKAN KEMANDIRIAN ANAK USIA 5-6 TAHUN DI RA AL-IZZAH KOTA SERANG
Authors: Fitriani Desy Nur , Maryani Kristiana , Atikah Cucu 
Published: August 2023

<span>Kemandirian adalah suatu sikap dan perilaku yang tidak mudah bergantung dengan orang lain dalam menyelesaikan tugas-tugasnya. Kemandirian juga merupakan sikap yang harus dibentuk oleh guru dan orang tua untuk membangun kepribadian anak. Tujuan dari penelitian ini adalah untuk menganalisis kemandirian anak usia 5-6 tahun, upaya guru dalam mengoptimalkan kemandirian anak usia 5-6 tahun, bentuk kerjasama guru dan orangtua dalam mengoptimalkan kemandirian anak, dan upaya guru dalam mengevaluasi kemandirian anak. Penelitian ini menggunakan pendekatan kualitatif dengan jenis penelitian yaitu penelitian kualitatif deskriptif. Teknik pengumpulan data yang dilakukan menggunakan metode observasi, wawancara dan dokumentasi. Peneliti menggunakan instumen pendukung berupa pedoman observasi dan pedoman wawancara. Teknik analisis yang digunakan adalah analisis deskriptif dengan menggunakan <em>field research</em>. Hasil dari penelitian ini adalah kemandirian anak sudah berkembang sesuai harapan terlihat ketika anak mampu berinisiatif, anak memiliki rasa percaya diri, anak tidak bergantung pada orang lain, dan anak mampu menyelesaikan masalah. Upaya guru dalam mengoptimalkan kemandirian anak dilakukan melalui pembiasaan terkait dengan kegiatan anak dalam kesehariannya. Kerjasama antara guru dan orangtua dilakukan dengan menjalin komunikasi secara berkesinambungan baik itu secara langsung maupun melalui WA Grup serta pertemuan rutin komite sekolah. Dan evaluasi guru terhadap kemandirian anak dilaksanakan dengan cara pengumpulan dan pengolahan informasi yang diantaranya dengan menggunakan catatan anekdot.</span>
SIMBOL MULTIKULTURALISME PADA IMAJI HIBRID PAKSI NAGA LIMAN KERATON KANOMAN CIREBON
Authors: Effendi Ismet Zainal 
Published: August 2023

Artikel ilmiah ini fokus pada kajian simbol mutikultural yang terdapat pada Paksi Naga Liman Keraton Kanoman Cirebon. Pemilihan Keraton Kanoman, dengan pertimbangan artefak dan peninggalan sejarah yang tersimpan di keraton, memperlihatkan nilai artistik dan fungsional sebagai suatu produk seni-budaya dan memiliki nilai-nilai simbolik religio-magis. Paksi Naga Liman, merupakan sosok jejaden yakni sosok makhluk hibrid yang berwujud ganjil, yakni, berkepala naga, berbelalai dan berbadan gajah, bersayap burung pemangsa, bertaring, dan belalainya melilit sebuah senjata tradisional berupa ‘cakra-trisula’. Pemilihan Paksi Naga Liman, karena merupakan warisan budaya Nusantara yang perlu dijaga dan digali makna historis dan simbolis khususnya dalam konteks hibriditas sebagai karakter nilai-nilai yang dimiliki bangsa Indonesia. Penelitian ini merupakan penelitian kualitatif dengan melakukan kajian-kajian terhadap imaji mitos Paksi Naga Liman yang ada di Keraton Kanoman Cirebon. Hasil penelitian menunjukkan. Hasil kajian menunjukan terdapat spirit multikulturalisme pada Paksi Naga Liman, secara historik-diakronik merupakan simbol akulturasi dalam Kerajaan Cirebon. Paksi, merupakan pengaruh kebudayaan Islam yang dibawa oleh orang-orang Mesir ke Cirebon. Naga, merupakan pengaruh dari Negeri Tiongkok yang masik ke wilayah Cirebon, dan Liman, merupakan pengaruh dari kebudayaan Hindu yang dibawa oleh orang-orang India ke Cirebon.
PENGARUH MEDIA PEMBELAJARAN FILM KARTUN UNTUK MENINGKATKAN KEMAMPUAN BERBICARA DALAM MENCERITAKAN KEGEMARAN SISWA DI KELAS II SDN 1 SUKAMULYA
Authors: Sinta Wati Ajeng , Dessy Wardiah  , Aldora Pratama  
Published: August 2023

The Influence Of Cartoon Learning Media To Improve The Ability To Tell Student' Hobbie In Grade II SDN 1 Sukamulya. The purpose of this study was to determine the influence of cartoon ffilm media to improve speaking skills in telling students' hobbies in grade II SDN 1 Sukamulya. This research uses the One Group Pretest Design method – Posstest Design. The unit of analysis in this study is the cartoon film "The Samson Family and the Fahriani Family". The sampling technique in this study is by Purposive Sampling. Data was collected using observation instruments, documentation and tests. The data was analyzed using the N-Gain Score (Normailized Gain) formula. It can be seen that the use of cartoon film media and the speaking ability of students in grade II SDN 1 Sukamulya has an effect in accordance with expectations. Through this cartoon film media, students are able to improve their speaking skills in telling students' hobbies.
Keywords: cartoon film media, speaking ability
PENGARUH PENGGUNAAN MEDIA SCRAPBOOK TERHADAP MOTIVASI BELAJAR IPS KELAS IV SDN
Authors: Alpia  , Rury Rizhardi  , Ida Suryani  
Published: August 2023

Media scrapbook which packaged in book form by combining various pieces of images as well as explanations that are expected to attract the attention and activity of students This study aims to determine whether there is an influence of the use of scrapbook media on the motivation to learn social studies grade IV SD Negeri 22 Palembang. This research design is a pre-experimental research with the design of The One Group Pretest-Posttest design. The population of this study was the entire class IV of SDN 22 Palembang which amounted to 24 people. The sample is determined by random sampling technique. The sample of this study was students conducted using test methods in the form of multiple choice and questionnaires measuring learning motivation. The results showed that there was an influence of the use of scrapbook media on the motivation to learn social studies SDN 22 Palembang. This is shown from the paired test results of the T-test sample, pretest data and posttest learning motivation get a signification value of 0.819 < 0.005, then Ho is rejected and Ha is accepted.
Keywords: Media, Scrapbook, Learning motivation
Sistem Hukum Modern Lawrance M. Friedman: Budaya Hukum dan Perubahan Sosial Masyarakat dari Industrial ke Digital
Authors: Al Kautsar Izzy , Muhammad Danang Wahyu 
Published: August 2023

Abstrak
Tujuan dari penelitian ini adalah untuk menganalisa hubungan antara perubahan sosial masyarakat dengan sistem hukum nasional dan mengidentifikasi sistem hukum modern Lawrance Friedman dalam perubahan sosial masyarakat dari industrial ke digital. Penelitian ini menggunakan metode penelitian normatif dengan pendekatan filosofis. Hasil dari penelitian ini adalah: (1) Hubungan antara perubahan sosial dengan sistem hukum dapat diamati melalui terbentuknya budaya hukum dalam masyarakat, perubahan sosial yang membawa dampak positif membawa masyarakat untuk lebih mawas terhadap perintah dan larangan dalam hukum sehingga menciptakan kesadaran hukum; (2) Masyarakat industri yang awalnya memiliki pola kebiasaan dan perilaku untuk memanfaatkan teknologi mesin untuk sarana memproduksi barang dalam rangka memperkaya nilai ekonomi mereka, kini sejalan dengan gagasan baru arus dimensi perubahan sosial, pelan tapi pasti telah berubah pola kebiasaanya menjadi masyarakat digital. Dengan adanya social of changes ini juga menimbulkan fenomena society forces laws.
Kata Kunci: Perubahan Sosial, Sistem Hukum

Abstract
This study aims to analyze the relationship between social change in society and the national legal system and identify Lawrence Friedman's modern legal system in society's social change from industrial to digital. This study uses a normative research method with a philosophical approach. The results of this study are: (1) The relationship between social change and the legal system can be observed through the formation of legal culture in society. Social changes that have a positive impact bring people to be more aware of commands and prohibitions in law to create legal awareness. (2) Industrial society, which initially had a pattern of habits and behavior to utilize machine technology as means of producing goods in order to enrich their economic value, is now in line with the new idea of ​​the flow of dimensions of social change, slowly but surely changing its habitual pattern into a digital society. These social changes also give rise to the phenomenon of society forces laws.
Keywords: Social Change, Legal System
Legal Consideration in Implementing Artificial Intelligence when Dealing with Patients in Healthcare Services
Authors: Yuliana Yuliana 
Published: August 2023

Artificial intelligence (AI) is applied in large activities of daily life. However, besides the positive sides of AI, there are still many legal concerns about implementing AI in medical practice and healthcare services. Ethical consideration needs legal background involvement. This paper aims to describe the legal consideration in implementing Artificial Intelligence (AI) when dealing with patients in healthcare services. This is a narrative literature review. Literature was searched from Science Direct, Google Scholar, and PubMed. The inclusion criteria are research and review. The exclusion criteria are unavailable in full-text journals. The articles were read twice to reduce the possibility of bias. Finally, the selected articles were summarized and narrated in a review. Possible pitfalls in legal concerns when using Artificial Intelligence when dealing with patients include patient privacy, data sharing, rigorous testing procedure, and expensive process. Unification and harmonization of legal regimes have to be applied for legal regulation. Non-discriminative principles are required to ensure legal liability. Legal concerns about implementing Artificial Intelligence (AI) in healthcare services include patient privacy, data sharing, and testing procedure. Legal liability should be ensured by non-discriminative principles.