bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk of bullous pemphigoid and pemphigus in patients on chronic dialysis: A nationwide population‐based cohort study
Authors: Tang Chao‐Hsiun , Sue Yuh‐Mou , Chang Chia‐Li , Wang Chia‐Chen 
Published: September 2023

AbstractBullous pemphigoid has a high incidence among dialysis patients. However, whether or not chronic dialysis is an independent risk factor of bullous pemphigoid remains unclear. We aimed to investigate the effect of chronic dialysis on the development of bullous pemphigoid and pemphigus. We performed a retrospective cohort study using records from Taiwan's National Health Insurance Research Database between 2008 and 2019. We identified a dialysis cohort that included patients on chronic hemodialysis and peritoneal dialysis, and the hazard ratios (HRs) for bullous pemphigoid and pemphigus were compared with those of a sex‐, age‐, and index‐matched cohort, then the results were adjusted for various confounding factors. Among 93 538 patients on chronic dialysis and 93 538 patients in the control group, 287 and 139 developed incident bullous pemphigoid, and 45 and 35 developed incident pemphigus after a median follow‐up of 3.7 and 5.6 years, respectively. The incidence rates of bullous pemphigoid in the dialysis patients and the control group were 74.2 and 25.2 per 100 000 person‐years, respectively (difference between groups, P < 0.0001). The incidence rates of pemphigus in the dialysis patients and the control group were 11.6 and 6.3 per 100 000 person‐years, respectively (difference between groups, P < 0.01). Cox proportional hazard adjustment showed the HR for bullous pemphigoid in dialysis patients was 2.12 (95% confidence interval [CI] 1.64–2.74, P < 0.0001) compared with the control group. Dialysis patients aged <75 years had an even higher risk of bullous pemphigoid development (5‐ to 8‐fold) than the control group. The adjusted HR for pemphigus was not elevated in dialysis patients (adjusted HR 1.52, 95% CI 0.87–2.67, P = 0.14). Chronic dialysis is an independent risk factor for developing bullous pemphigoid, but not a risk factor for pemphigus. Physicians should be aware of the predisposition of chronic dialysis patients to bullous pemphigoid.
Therapeutic effectiveness of upadacitinib on individual types of rash in Japanese patients with moderate‐to‐severe atopic dermatitis
Authors: Hagino Teppei , Yoshida Mai , Hamada Risa , Fujimoto Eita , Saeki Hidehisa , Kanda Naoko 
Published: September 2023

AbstractAtopic dermatitis (AD) is a chronic eczematous disease with various types of rash, erythema, edema/papulation, excoriation, or lichenification. Janus kinase 1 inhibitor upadacitinib is effective for moderate‐to‐severe AD. We aimed to investigate the therapeutic effects of upadacitinib on each rash type in AD patients in real‐world clinical practice. Seventy‐two Japanese patients with moderate‐to‐severe AD were treated with oral upadacitinib 15 mg/day plus topical corticosteroids. The Eczema Area and Severity Index (EASI) scores for erythema, edema/papulation, excoriation, or lichenification on the whole body or on head and neck, upper limbs, lower limbs, or trunk were assessed at weeks 0, 4, and 12 of treatment. The proportions of patients who achieved resolution or at least 75% reduction of EASI from baseline (EASI 75) for individual rash types were calculated at weeks 4 and 12 on the whole body or each anatomical site. The resolution rates for excoriation, erythema, edema/papulation, or lichenification on the whole body were 38.3%, 23.7%, 21.7%, and 8.3% at week 4 and 18.3%, 18.6%, 11.6%, and 13.3% at week 12, respectively. The EASI scores for all rash types significantly decreased at weeks 4 and 12 compared to week 0. The achievement rates of EASI 75 for excoriation, erythema, edema/papulation, or lichenification on the whole body were 67.2%, 66.7%, 49.2%, and 37.7% at week 4 and 57.3%, 65%, 41%, and 41% at week 12, respectively. The achievement rate of EASI 75 for erythema on head and neck at week 4 (45.3%) was lower than that on upper limbs (71%) and on lower limbs (70.8%), and that on head and neck at week 12 (42.2%) was lower than that on lower limbs (69.2%). These results indicate that upadacitinib is effective for all AD rash types, especially for excoriation and erythema, while head‐and‐neck erythema might be less responsive to upadacitinib.
Skin manifestations and biophysical changes following weight reduction induced by bariatric surgery: A 2‐year prospective study
Authors: Triwatcharikorn Jidapa , Itthipanichpong Yada , Washrawirul Chanudda , Chuenboonngarm Nunthanach , Chongpison Yuda , Udomsawaengsup Suthep , Boonchaya‐Anant Patchaya , Rerknimitr Pawinee 
Published: September 2023

AbstractSkin manifestations and biophysical changes are observed in patients with morbid obesity. However, reports of changes after significant weight loss, particularly through post‐bariatric surgery (BaS), are limited. The aim of this 2‐year prospective study was to evaluate the prevalence of skin signs and their changes in patients with morbid obesity who underwent BaS. Thirty‐one patients were recruited for the study, with a mean age of 38.35 (SD 10.61) years and a male preponderance (male = 19 [61.29%], female = 12 [38.71%]). Patients were scheduled for multiple visits at months 0, 3, 6, 12, 18, and 24 post‐BaS. Each subject had a thorough skin examination, biophysical measurements, and laboratory tests at each visit. Striae, acanthosis nigricans (AN), and plantar hyperkeratosis were the most common skin findings (n = 30 [96.77%], 29 [93.55%], 29 [93.55%], respectively). BaS provided improvements in many skin manifestations, namely striae, AN, acrochordons, plantar hyperkeratosis, hirsutism, lymphedema, pruritus, acne, finger pebbles, and chronic venous insufficiency with varied cumulative rates of improvements. However, acute telogen effluvium was observed in 17 (54.84%) patients. Regarding skin biophysical properties, transepidermal water loss, skin hydration, and pH did not change, while sebum production on the face significantly decreased at months 3 and 6, and elasticity decreased at months 6 and 24. In conclusion, weight reduction by BaS provided improvements in various skin signs, although telogen effluvium was a common sequelae.
Evaluating the determinants of load capacity factor in Japan: The impact of economic complexity and trade globalization
Authors: Awosusi Abraham Ayobamiji , Adebayo Tomiwa Sunday , Kirikkaleli Dervis , Rjoub Husam , Altuntaş Mehmet 
Published: September 2023

AbstractSustainable growth and the reduction of environmental pressures are important priorities that are issues of concern for both developed and developing countries. However, while carbon emissions and ecological footprint are commonly used by researchers in the context of environmental deterioration, a broader and more extensive metric for ecological quality is considered necessary. From this perspective, the load capacity factor provides a more detailed sustainable environment appraisal by simultaneously considering biocapacity and ecological footprint. Limited studies have examined the determinants of load capacity factor (LCAP). This survey attempts to fill the gap, using the case of Japan. Employing the dynamic ARDL approaches, the present research investigates the effect of renewable energy usage, economic growth, economic complexity, financial development, and trade globalization on load capacity factor in Japan for the period between 1980 and 2017. The empirical evidence indicates that economic complexity, economic growth, and financial development adversely impact LCAP, whereas renewable energy usage and trade globalization positively affect LCAP. Hence, we recommend that it is essential for Japan to attain self‐sufficiency in essential goods and minimize its reliance on the rest of the world. Furthermore, policymakers should capitalize on the benefits of trade globalization by adopting additional measures aimed at facilitating trade liberalization.
Trends in maintaining postharvest freshness and quality of Rubus berries
Authors: Shah Hafiz Muhammad Shoaib , Singh Zora , Kaur Jashanpreet , Hasan Mahmood Ul , Woodward Andrew , Afrifa‐Yamoah Eben 
Published: September 2023

AbstractBlackberries and raspberries, commonly known as Rubus berries, are commercially grown worldwide across different climates. Rubus berries contain wide array of phytochemicals, vitamins, dietary fibers, minerals, and unsaturated fatty acids. Nevertheless, these berries have short storage life which is the major constraint in their supply chains leading to higher postharvest losses. Inappropriate harvest handling, physical bruising, insect pests, and postharvest diseases lower the acceptability of fruit among consumers and other supply chain stakeholders. Additionally, the susceptibility to microbial decay, fruit softening, higher ethylene production, respiratory activity, and increased oxidation of anthocyanins, phenolics, and flavonoids considerably affects the marketability of Rubus berries at domestic and international markets. To date, several postharvest strategies such as cold storage, precooling, modified and controlled atmospheres, anti‐ripening chemicals, edible coatings, biological agents, and nonchemical alternatives (heat treatment, ultrasound, irradiations, ozone) have been reported to prolong storage life, ensure food safety, and maintain the nutritional quality of Rubus berries. This review briefly encompasses multiple aspects including harvest maturity indices, regulation of fruit ripening, pre and postharvest factors affecting fruit quality, and an update on postharvest quality preservation by employing postharvest technologies to extend the storage life and maintaining the bioactive compounds in Rubus berries which are lacking in the literature. Accordingly, this review provides valuable information to the industry stakeholders and scientists offering relevant solutions, limitations in the application of certain technologies at commercial scale, highlighting research gaps, and paving the way forward for future investigations.
Flowering phenology and reproductive success of native shrub Berberis darwinii Hook. along different light environments
Authors: Svriz Maya , Lediuk Karen D. , Agüero Mariana L. , Damascos María A. , Scervino José M. 
Published: September 2023

AbstractStudies evaluating flowering phenology and reproductive success are necessary when we want to direct a domestication project in a species with a potential productive value. We studied flowering phenology and reproductive success of Berberis darwinii growing under different light conditions in its native distribution area in the Andean Patagonian forests of Argentina. We test the hypothesis that plants grown under conditions of high‐light availability exhibit advanced phenology and higher reproductive success than those grown under conditions of lower light availability. Phenology and reproductive success were determined in three contrasting light conditions at two forest sites, which were, canopy, gap and forest edge. Plants did not bloom under the forest canopy. Flowering and fruiting period lengths were similar in both sites and light conditions of gap and forest edge during spring and summer. Although gap plants had more racemes per shoot, racemes of edge plants had more flowers, fruits and a higher proportion of flowers producing ripe fruit. We show that B. darwinii reproduction studied in the Andean Patagonian forests is conditioned by the canopy openness. Regarding reproductive success, edge plants invest less resources in flower production than gap plants to have similar fruit production.
Decreased level of TREM like Transcript 1 (TLT‐1) is associated with prematurity and promotes the in‐utero inflammatory response to maternal lipopolysaccharide (LPS) exposure
Authors: Peña‐Garcia Paola E. , Morales‐Ortiz Jessica , Marrero‐Polanco Jean , Virgillio Ariana , Finette Barry A. , Washington Anthony V. , Bonney Elizabeth A. 
Published: September 2023

AbstractProblemThe occurrence of preterm birth is associated with multiple factors including bleeding, infection and inflammation. Platelets are mediators of hemostasis and can modulate inflammation through interactions with leukocytes. TREM like Transcript 1 (TLT‐1) is a type 1 single Ig domain receptor on activated platelets. In adults, it plays a protective role by dampening the inflammatory response and facilitating platelet aggregation at sites of vascular injury. TLT‐1 is expressed in human placenta and found in cord blood. We thus hypothesized that TLT‐1 deficiency is associated with prematurity and fetal inflammation.Method of studyTo test this hypothesis, we examined cord blood levels of soluble TLT‐1 (sTLT) in premature and term infants and compared the inflammatory response in C57BL/6 (WT) and TLT‐1−/− (treml1−/−, KO) mice given intraperitoneal LPS mid‐gestationResultsThe preterm infant cord blood level of sTLT was significantly lower than that found at term. On exposure to LPS, histology of KO (as compared to WT) placenta and decidua showed increased hemorrhage, and KO decidual RNA expression of IL‐10 was significantly lower. KO fetal interface tissues (placenta, membranes, amniotic fluid) over time showed increased expression of inflammatory cytokines such as IL‐6, IFN‐γ, and TNF, but not MCP‐1. However, fetal organs showed similar levels.ConclusionThere is a potential association between insufficient TLT‐1 expression and increased fetal inflammatory responses in the setting of prematurity. The data support further study of TLT‐1 in the mechanistic link between bleeding, inflammation and preterm birth, and perhaps as a biomarker in human pregnancy.
Western‐style diet in the presence of elevated circulating testosterone induces adipocyte hypertrophy without proinflammatory responses in rhesus macaques
Authors: Burwitz Benjamin J. , Yusova Sofiya , Robino Jacob J. , Takahashi Diana , Luo Addie , Slayden Ov D. , Bishop Cecily V. , Hennebold Jon D. , Roberts Charles T. , Varlamov Oleg 
Published: September 2023

AbstractProblemAnovulatory infertility is commonly associated with hyperandrogenemia (elevated testosterone, T), insulin resistance, obesity, and white adipose tissue (WAT) dysfunction associated with adipocyte hypertrophy. However, whether hyperandrogenemia and adipocyte hypertrophy per se induce a proinflammatory response is unknown.Method of studyYoung adult female rhesus macaques were exposed to an obesogenic Western‐style diet (WSD) in the presence of elevated circulating testosterone (T+WSD) or a low‐fat control diet with no exogenous T. Immune cells residing in visceral omental white adipose tissue (OM‐WAT), corpus luteum and the contralateral ovary, endometrium, lymph nodes, bone marrow, and peripheral blood mononuclear cells were characterized by flow cytometry during the luteal phase of the reproductive cycle.ResultsFollowing one year of treatment, T+WSD animals became more insulin‐resistant and exhibited increased body fat and adipocyte hypertrophy compared to controls. T+WSD treatment did not induce macrophage polarization toward a proinflammatory phenotype in the tissues examined. Additionally, T+WSD treatment did not affect TNFα production by bone marrow macrophages in response to toll‐like receptor agonists. While the major lymphoid subsets were not significantly affected by T+WSD treatment, we observed a significant reduction in the frequency of effector memory CD8+ T‐cells (Tem) in OM‐WAT, but not in other tissues. Notably, OM‐WAT Tem frequencies were negatively correlated with insulin resistance as assessed by the Homeostatic Model Assessment for Insulin Resistance (HOMA‐IR).ConclusionThis study shows that short‐term T+WSD treatment induces weight gain, insulin resistance, and adipocyte hypertrophy, but does not have a significant effect on systemic and tissue‐resident proinflammatory markers, suggesting that adipocyte hypertrophy and mild hyperandrogenemia alone are not sufficient to induce a proinflammatory response.
LncRNA AOC4P impacts the differentiation of macrophages and T‐lymphocyte by regulating the NF‐κB pathways of KGN cells: Potential pathogenesis of polycystic ovary syndrome
Authors: Yang Zhe , Wu Shujuan , He Shaojing , Han Lu , Zhou Mengqi , Yang Jing , Chen Jiao , Wu Gengxiang 
Published: September 2023

AbstractBackgroundPolycystic ovary syndrome (PCOS) is a multifactorial endocrine disease, which is an important cause of female infertility worldwide. PCOS patients are in a state of chronic low‐grade inflammation, and immune imbalance is considered as a potential cause of its pathogenesis.MethodsThe expression of AOC4P in PCOS and normal ovarian granulosa cells (GCs) was detected by real‐time quantitative PCR. KGN cells were induced by dihydrotestosterone at 500 ng/mL to construct the PCOS model. After lentivirus‐infected, KGN cells were constructed with AOC4P overexpression cell lines, the proliferation and apoptosis levels of KGN cells in AOC4P and NC groups were detected. Human monocyte cell line (THP‐1)‐derived macrophages and peripheral blood mononuclear cells (PBMC) were co‐cultured with KGN cells for 48 h, respectively, and the differentiation of macrophages and CD4+ T cells were detected by flow cytometry.ResultsDecreased AOC4P expression was found in PCOS patients. After constructing the PCOS cell model, we observed that overexpression of AOC4P promoted KGN cell proliferation and inhibited apoptosis. After co‐culture with AOC4P overexpressed KGN cells, M1 macrophages decreased, M2 macrophages increased, T helper cells type 1 (Th1)/Th2 ratio increased, and regulatory T cell (Treg) cells increased. Finally, we found that AOC4P inhibited the activation of the nuclear factor κ B (NF‐κB) pathway in KGN cells.ConclusionsIn this study, we found that AOC4P regulated the NF‐κB signaling pathway by inhibiting the phosphorylation of P65, thereby affecting the proliferation and apoptosis of GCs, altering the differentiation of macrophages and T cells, thus contributing to the pathogenesis of PCOS.
Signal quality of home polygraphy in children and adolescents
Authors: Hansen Camilla , Sonnesen Liselotte , Markström Agneta 
Published: September 2023

AbstractAimThe aims of the study were to examine the signal quality (SQ) of home polygraphy (PG) in children and adolescents and to compare automatic and manual scoring of the PGs.MethodsClinical Trials Registration: NCT04964830. Participants and caregivers were instructed to set up the equipment and perform home PGs themselves. The PGs were analysed according to SQ and their interpretability and differences in automatic vs. manual scoring regarding apnoea–hypopnoea index (AHI), apnoea index (AI), hypopnoea index (HI) and oxygen desaturation index (ODI) were examined.Results54 healthy children aged 9–14 years participated in the study. 86% of the PGs were interpretable with mean SQ of 79.1% (CI 95%: 73.5%; 84.8%). Significant differences between the automatic and manual scoring were found for AHI, AI, HI and ODI (p < 0.0001).ConclusionHome PGs of children and adolescents are feasible to be performed with good SQ. Significantly higher markers of sleep‐disordered breathing were achieved in the automatic scoring in comparison with the manual scoring.
GDF15 mediates renal cell plasticity in response to potassium depletion in mice
Authors: Lasaad Samia , Walter Christine , Rafael Chloé , Morla Luciana , Doucet Alain , Picard Nicolas , Blanchard Anne , Fromes Yves , Matot Béatrice , Crambert Gilles , Cheval Lydie 
Published: September 2023

AbstractObjectiveTo understand the mechanisms involved in the response to a low‐K+ diet (LK), we investigated the role of the growth factor GDF15 and the ion pump H,K‐ATPase type 2 (HKA2) in this process.MethodsMale mice of different genotypes (WT, GDF15‐KO, and HKA2‐KO) were fed an LK diet for different periods of time. We analyzed GDF15 levels, metabolic and physiological parameters, and the cellular composition of collecting ducts.ResultsMice fed an LK diet showed a 2–4‐fold increase in plasma and urine GDF15 levels. Compared to WT mice, GDF15‐KO mice rapidly developed hypokalemia due to impaired renal adaptation. This is related to their 1/ inability to increase the number of type A intercalated cells (AIC) and 2/ absence of upregulation of H,K‐ATPase type 2 (HKA2), the two processes responsible for K+ retention. Interestingly, we showed that the GDF15‐mediated proliferative effect on AIC was dependent on the ErbB2 receptor and required the presence of HKA2. Finally, renal leakage of K+ induced a reduction in muscle mass in GDF15‐KO mice fed LK diet.ConclusionsIn this study, we showed that GDF15 and HKA2 are linked and play a central role in the response to K+ restriction by orchestrating the modification of the cellular composition of the collecting duct.
Letter: the use of Fibrosis‐4 score in primary care and diabetology practices—Occam’s razor applied to advanced fibrosis screening
Authors: Yilmaz Yusuf , Kaya Eda , Eren Fatih 
Published: September 2023

LINKED CONTENTThis article is linked to Younossi et al and Younossi & Henry papers. To view these articles, visit https://doi.org/10.1111/apt.15830 and https://doi.org/10.1111/apt.16091
Editorial: the microbiome, aspirin and colorectal cancer
Authors: O’Grady John , Quigley Eamonn M. M. 
Published: September 2023

LINKED CONTENTThis article is linked to Prizment et al papers. To view these articles, visit https://doi.org/10.1111/apt.16013 and https://doi.org/10.1111/apt.16115
Impact of hepatitis C virus treatment on the risk of non‐hepatic cancers among hepatitis C virus‐infected patients in the US
Authors: Wang Wei , Lo Re Vincent , Guo Yi , Xiao Hong , Brown Joshua , Park Haesuk 
Published: September 2023

SummaryBackgroundHepatitis C virus (HCV) infection is associated with with an increased risk of non‐hepatic cancers, but the impact of HCV treatment on non‐hepatic cancer is unclear.AimsTo assess if HCV treatment reduced the incidence of non‐hepatic cancers among patients with chronic HCV infection in the US.MethodsWe conducted a retrospective cohort study in MarketScan Databases from January 2005 to December 2016. Multivariable, time‐varying Cox proportional‐hazards models were used to determine hazard ratios (HRs) of incident non‐hepatic cancers in treated and untreated patients with HCV infection. We conduscted subgroup analyses for sex, age, and presence of cirrhosis or diabetes.ResultsAmong 62 078 patients with newly diagnosed HCV infection, 17 302 (28%) initiated HCV treatment, among whom 15 322 completed 8‐16 weeks treatment (minimally effective treatment). Patients who initiated HCV treatment had an 11% decreased risk of developing an incident non‐hepatic cancer compared to untreated patients (HR = 0.89, 95% confidence interval (Cl) = 0.82‐0.96). The reduction was slightly higher when patients completed a minimally effective treatment (HR = 0.87; 95% Cl = 0.80 ‐ 0.95). This was observed in most subgroup analyses for those who had a minimally effective treatment including patients with cirrhosis. When we stratified cancer or therapy subtypes, the association remained consistent for pancreatic and lung cancers, and dual HCV therapy.ConclusionsHCV treatment led to a significantly reduced incidence of non‐hepatic cancers among patients with HCV infection. Despite discrepancies between cancer or HCV therapy subtypes, our findings suggest that treating HCV infection can decrease the extrahepatic cancer burden associated with chronic HCV infection.
Letter: the use of Fibrosis‐4 score in primary care and diabetology practices—Occam's razor applied to advanced fibrosis screening. Authors' reply
Authors: Younossi Zobair M. , Henry Lind 
Published: September 2023

LINKED CONTENTThis article is linked to Younossi et al and Younossi and Henry papers. To view these articles, visit https://doi.org/10.1111/apt.15830 and https://doi.org/10.1111/apt.16034
Editorial: tenofovir alafenamide fumarate—a new bullet to prevent mother‐to‐child transmission of hepatitis B virus. Authors' reply
Authors: Pan Calvin Q. , Cao Lihua , Huang Yan 
Published: September 2023

LINKED CONTENT
This article is linked to Ding et al and Gish & Elmofti papers. To view these articles, visit https://doi.org/10.1111/apt.16043 and https://doi.org/10.1111/apt.16090