bluuebunny/crossref_metadata_2025_split huggingface dataset:
Kinetically inert manganese (II)-based hybrid micellar complexes for magnetic resonance imaging of lymph node metastasis
Authors: Chen Kai , Cai Zhongyuan , Cao Yingzi , Jiang Lingling , Jiang Yuting , Gu Haojie , Fu Shengxiang , Xia Chunchao , Lui Su , Gong Qiyong , Song Bin , Ai Hua 
Published: May 2023

Abstract
The localization and differential diagnosis of the sentinel lymph nodes (SLNs) are particularly important for tumor staging, surgical planning and prognosis. In this work, kinetically inert manganese (II)-based hybrid micellar complexes (MnCs) for magnetic resonance imaging (MRI) were developed using an amphiphilic manganese-based chelate (C18-PhDTA-Mn) with reliable kinetic stability and self-assembled with a series of amphiphilic PEG-C18 polymers of different molecular weights (C18En, n = 10, 20, 50). Among them, the probes composed by 1:10 mass ratio of manganese chelate/C18En had slightly different hydrodynamic particle sizes with similar surface charges as well as considerable relaxivities (∼13 mM−1 s−1 at 1.5 T). In vivo lymph node imaging in mice revealed that the MnC MnC-20 formed by C18E20 with C18-PhDTA-Mn at a hydrodynamic particle size of 5.5 nm had significant signal intensity brightening effect and shortened T1 relaxation time. At an imaging probe dosage of 125 μg Mn/kg, lymph nodes still had significant signal enhancement in 2 h, while there is no obvious signal intensity alteration in non-lymphoid regions. In 4T1 tumor metastatic mice model, SLNs showed less signal enhancement and smaller T1 relaxation time variation at 30 min post-injection, when compared with normal lymph nodes. This was favorable to differentiate normal lymph nodes from SLN under a 3.0-T clinical MRI scanner. In conclusion, the strategy of developing manganese-based MR nanoprobes was useful in lymph node imaging.
EPCR deficiency ameliorates inflammatory arthritis in mice by suppressing the activation and migration of T cells and dendritic cells
Authors: Xue Meilang , Lin Haiyan , Liang Hai Po Helena , Bereza-Malcolm Lara , Lynch Tom , Sinnathurai Premarani , Weiler Hartmut , Jackson Christopher , March Lyn 
Published: May 2023

Abstract

Objectives
Endothelial protein C receptor (EPCR) is highly expressed in synovial tissues of patients with RA, but the function of this receptor remains unknown in RA. This study investigated the effect of EPCR on the onset and development of inflammatory arthritis and its underlying mechanisms.

Methods
CIA was induced in EPCR gene knockout (KO) and matched wild-type (WT) mice. The onset and development of arthritis was monitored clinically and histologically. T cells, dendritic cells (DCs), EPCR and cytokines from EPCR KO and WT mice, RA patients and healthy controls (HCs) were detected by flow cytometry and ELISA.

Results
EPCR KO mice displayed &gt;40% lower arthritis incidence and 50% less disease severity than WT mice. EPCR KO mice also had significantly fewer Th1/Th17 cells in synovial tissues with more DCs in circulation. Lymph nodes and synovial CD4 T cells from EPCR KO mice expressed fewer chemokine receptors CXCR3, CXCR5 and CCR6 than WT mice. In vitro, EPCR KO spleen cells contained fewer Th1 and more Th2 and Th17 cells than WT and, in concordance, blocking EPCR in WT cells stimulated Th2 and Th17 cells. DCs generated from EPCR KO bone marrow were less mature and produced less MMP-9. Circulating T cells from RA patients expressed higher levels of EPCR than HC cells; blocking EPCR stimulated Th2 and Treg cells in vitro.

Conclusion
Deficiency of EPCR ameliorates arthritis in CIA via inhibition of the activation and migration of pathogenic Th cells and DCs. Targeting EPCR may constitute a novel strategy for future RA treatment.
A challenging path to rational and harmonised international regulation of indoor radon
Authors: Kovler Konstantin , Tsapalov Andrey 
Published: May 2023

Abstract
The main trends of indoor radon regulation in Europe are expressed through the standard ISO 11665-8. This standard, however, ignores the short-term tests (2–7 days in practice)—the main tests in the USA, and instead requires conducting long-term tests only (2–12 months)—without any justification. Moreover, the temporal (key) uncertainty of indoor radon is ignored altogether, a fact that does not allow the assessment of a room’s conformity with a normative at a given reliability (usually 95%). Thus, the current international regulation is neither harmonised nor rational. This paper reports the interim results of storming discussions within the ISO 11665-8 Focus Group, in charge of revising the aforementioned standard. Proposed are the rational criterion for conformity assessment of a room with a normative for both short- and long-term measurements, as well as the indicative values and the algorithm for determining indoor radon temporal uncertainty depending on the measurement duration.
Mediating probate and trust disputes—process challenges and tools: part 2
Authors: Islam Carl Amir-Ul 
Published: May 2023

Abstract
In Part 1, the author discussed ‘Preparation’, including the making of pre-mediation day Zoom/TEAMS calls and a checklist of issues for the mediator to run through at the start of the mediation day to ensure that each participant understands and is bound by the ‘ground rules’. In this part, the author discusses the challenges and tools available to a mediator during the mediation day to help create and manage an effective conversation between the participants. In addition, towards the end of the article, Mr Jacob J Meagher has contributed commentary on the Singapore Convention on Mediation (SCM), highlighting significant opportunities that may arise, depending upon how the SCM is enacted.
The liability of the foundation board under Austrian Private Foundation Law
Authors: Müller Katharina , Melzer Martin 
Published: May 2023

Abstract
The issue of liability is one of the most central in Austrian private foundation law. Experience has shown that the often close relationship between the generation of the first founders and the members of the foundation board is a reason for underestimating liability. Many foundation board members are unaware that the Austrian Private Foundation Act (Privatstiftungsgesetz) regulates the liability of the foundation board by analogy to the liability law provisions for corporations—and thus rather strictly. What often starts as a “friendship service” can have considerable consequences under liability law.
In Defence of White Freedom: Working Men’s Clubs and the Politics of Sociability in Late Industrial England
Authors: Schofield Camilla 
Published: May 2023

Abstract
While ongoing discrimination in jobs, welfare, and housing in 1970s England belied the social democratic promise of ‘equality of opportunity’ and the much-touted British value of ‘fair play’, racism at the door of the working men’s club told a different story. For reactionaries and liberals alike, it spoke to the uncertain future of working-class politics in late industrial England. This article shows how the legal and political controversies surrounding whites-only working men's clubs contribute to our understanding of the ‘white working class’ as a political subject in British public life. Even more, it reveals how—among club members—whiteness came to be invested with feelings of intimacy, kinship, respectability, and independence.
The influence of the Italian model of hardship in Latin America and international trade (with some notes from social sciences)
Authors: García Long Sergio 
Published: May 2023

Abstract
This article studies the Italian model of hardship and how it has influenced Latin American jurisdictions and international trade. On the one hand, it develops how various national jurisdictions have imported the Italian model and how it has been followed by certain international instruments. On the other hand, economics and psychology are applied to analyse the good and bad of the Italian model. Finally, the article reflects on whether there is one model of hardship that is better than another and where the Italian model stands in this respect.
Age-Aware Organizations and the Relationship Between Shift Work and Psychological Well-being Across the Lifespan
Authors: Piszczek Matthew M , Yestrepsky Joseph M , Thrasher Gregory R 
Published: May 2023

Abstract
As the global workforce ages, it has become more important to understand how seemingly age-neutral HR practices can create unintended age-specific effects. For example, shift work—nominally an age-neutral HR practice—has been shown to have stronger negative effects on older workers’ physical and mental health. Although these effects are well established, how organizations can mitigate the age-specific effects of scheduling practices represents an important gap in the aging workforce literature. More specifically, the role of the organization in setting human resource practices and policies that are sensitive to older workers likely determines the strength of the age-specific effects of shift work on psychological well-being. Using mixed effects analyses in a large dataset of German employees and employers, we integrate lifespan psychology and HR strategy research to examine the relationship between shift work and psychological well-being across working lives. We then examine how the implementation of organizational age structure analysis may buffer this relationship. Results largely support the benefits of an active, “age-aware” approach to managing the aging workforce as psychological well-being increased with age among all workers except shift workers in establishments that did not conduct an age structure analysis.
10Plastic Theory/Studies
Authors: Martell James 
Published: May 2023

Abstract
This chapter considers four of the most significant books on plastic theory and studies published in 2022: Alice Mah’s Plastic Unlimited: How Corporations Are Fuelling the Ecological Crisis and What We Can Do About It, Heather Davis’s Plastic Matter, Catherine Malabou’s Plasticity: The Promise of Explosion, and Ranjan Ghosh’s The Plastic Turn. It tries to show the common threads among these works and to see how their differences bespeak contemporary notions of plastic and plasticity that allow a diversity of thinkers to reflect not only on the emergency of a plastic and ecological crisis, but also on the role of ‘plastic thought’ in modernity, modern thought and science, and modernism. By way of conclusion, it looks at a notion that repeats itself among most of the volumes, the platonic term khôra, and how it relates to our conceptions of plasticity.
Piecing together the subtle clues of common variable immunodeficiency
Authors: Kochanoff Kimberly DeVore 
Published: May 2023

ABSTRACT
Common variable immunodeficiency (CVID) is a primary immunodeficiency disorder that results in decreased immunity and increased infection risk. This multisystem disorder often presents as recurrent, prolonged respiratory tract infections. Other manifestations include chronic lung disease, systemic granulomatous disease, malignancies, enteropathy, splenomegaly, and autoimmune disease including cytopenias. Diagnosis often is delayed, affecting patient quality of life, morbidity, and mortality. This article reviews the presentation, diagnosis, and management of patients with CVID.
Initiating Virtual Nursing in General Inpatient Care
Authors: Roberson Amy E. , Carlson Marny , Kohler Christopher M. , Harris Patricia A. , Volkmann Charlotte L. 
Published: May 2023

ABSTRACT:
With increased demands for inpatient care and limited nursing resources, bedside RNs at one health care system were challenged to find experienced nurse colleagues to provide mentorship when they needed assistance in executing best practices. A virtual RN (ViRN) role was created to support bedside RNs and patients on designated general care inpatient units. The ViRN provided real-time virtual clinical guidance to bedside RNs and actively surveilled patients. Bedside RNs were surveyed by email to gauge the utility and their perceptions of integrating ViRNs into the nursing care team. RNs reported that they valued the consistent availability of having the ViRNs' expert nursing knowledge and virtual assistance with nursing tasks.
The Energy a Plastic Surgeon Expends during Liposuction
Authors: Durán Vega Hector César , Lopez Echaury Alejandro , Flores Emanuel 
Published: May 2023

Background:
It is generally accepted that liposuction requires a significant amount of energy from surgeons. This procedure involves the use of specialized equipment and techniques to remove fat cells from the body, which can be physically demanding for surgeons. The amount of effort required for liposuction must be evaluated in terms of energy consumption. Our goal was to conduct a study to record the energy that the surgeon uses during liposuction and correlate these results with the volume of fat obtained as well as other variables.

Methods:
A series of cases was carried out from April 2022 to November 1, 2022, in three different plastic surgery centers. Three plastic surgeons recorded the procedures using an Apple Watch, choosing from among Apple Watch training options and free indoor walking. The surgeon then concluded the registration at the time of finishing the surgery and removed the surgical gloves and gowns.

Results:
Complete data were obtained for 63 patients. The average fat obtained per 1 kcal of energy was 6.14 cm3 of fat, and 160 cal to obtain 1 cm3 of fat by liposuction. Other data that demonstrated statistically significant correlations were fat volume versus average pace (km), total fat volume versus average heart rate, fat volume versus surgical time, and fat volume versus distance.

Conclusions:
Liposuction is a surgical procedure that requires considerable effort. This study demonstrates the amount of energy required for regular liposuction. Compared with other single procedures, three times more energy is required to complete liposuction.
Blood Product Replacement for Postpartum Hemorrhage
Authors: EID JOE , STAHL DAVID 
Published: May 2023

Consideration for blood products replacement in postpartum hemorrhage should be given when blood loss exceeds 1.5 L or when an estimated 25% of blood has been lost. In cases of massive hemorrhage, standardized transfusion protocols have been shown to improve maternal morbidity and mortality. Most protocols recommend a balanced transfusion involving a 1:1:1 ratio of packed red blood cells, platelets, and fresh frozen plasma. Alternatives such as cryoprecipitate, fibrinogen concentrate, and prothrombin complex concentrates can be used in select clinical situations. Although transfusion of blood products can be lifesaving, it does have associated risks.
Prevalence and Morphologic Biomarkers of Metamorphopsia in eyes with “Resolved” Chronic Central Serous Chorioretinopathy
Authors: Borrelli Enrico , Barresi Costanza , Battista Marco , Berni Alessandro , Ricardi Federico , Cascavilla Maria Lucia , Reibaldi Michele , Bandello Francesco 
Published: May 2023

ABSTRACT

Purpose:
To assess relationships between demographics, clinical characteristics and optical coherence tomography (OCT) characteristics with persistence of metamorphopsia after resolution of subretinal fluid in eyes with chronic central serous chorioretinopathy (CSC).

Methods:
One-hundred participants with “resolved” (absence of subretinal fluid) chronic CSC were retrospectively analyzed. Patients underwent a complete ophthalmological evaluation including assessment of presence of metamorphopsia. At the study visit, OCT scans were reviewed for qualitative and quantitative features.

Results:
Sixty-six out of 100 (66.0%) patients complained of metamorphopsia. Both the foveal and parafoveal ganglion cell complex (GCC) thicknesses were thinner in CSC eyes with metamorphopsia (35.1±10.6 μm and 82.0±18.1 μm vs. 40.7±11.8 μm and 93.1±13.5 μm, p=0.030 and p<0.0001). In the foveal region, the outer plexiform layer and outer nuclear layer (ONL) thicknesses were thinner in patients with metamorphopsia (24.6±8.5 μm and 63.1±20.9 μm vs. 29.1±8.7 and 76.2±18.2 μm, p=0.016 and p=0.005). The ellipsoid zone band was more frequently discontinued in eyes with metamorphopsia (56.1 % vs. 35.3%, p=0.039). Multivariate stepwise linear regression analysis demonstrated that the strongest associations with presence of metamorphopsia were with parafoveal GCC thickness (p=0.004), foveal ONL thickness (p=0.010), and number of previous recurrences of subretinal fluid accumulation (p=0.017). The time interval from the last subretinal fluid resolution was not associated with the presence of metamorphopsia.

Conclusions:
In “resolved” CSC, clinical aspects (i.e., number of previous recurrences) and structural changes (i.e., GCC and ONL thinning) are associated with metamorphopsia after subretinal fluid resolution.
Effects of a Blocked Versus Full-Length Semester Design on Doctor of Physical Therapy Student Performance and Retention
Authors: McCallister Erin , Bernard Amanda , Flowers Daniel W. , Rachal Sant Lauren 
Published: May 2023

Introduction.
Restrictions on in-person gatherings during the 2020 COVID-19 pandemic required educational programs to explore alternative educational formats. The nature of physical therapy education as a blend of cognitive and psychomotor skill presents additional challenges. During a gradual return to in-person learning, the authors' institution chose to break a full-length 15-week semester into 3, 5-week blocks. The first aim of this study was to evaluate the effects of semester design on course performance. The second aim was to assess the effects of semester design on knowledge and skill retention.

Review of Literature.
In undergraduate studies, blocked courses or semesters held over a short period of time may result in equal or better performance compared with courses performed over a longer time. Few studies have been performed on the graduate student population. Most studies have focused on short-term cognitive knowledge acquisition.

Subjects.
Three cohorts of Doctor of Physical Therapy (DPT) students were eligible to participate.

Methods.
Two DPT courses (1 first year and 1 second year) were selected to assess cognitive and psychomotor performance. Examination results were compared at the end of a full-length semester and blocked semester. A third course was selected to assess retention at 4 time points. Students were assessed on their cognitive retention using computer-based quizzes and psychomotor retention using in-person skills quizzes.

Results.
Median cognitive performance scores for both courses were slightly better during the blocked semester. There were no significant differences in median psychomotor scores. There was no significant interaction effect between semester structure and retention of cognitive knowledge or psychomotor skills, although there were significant changes in scores over time.

Discussion and Conclusion.
A blocked semester design may favor immediate cognitive performance. However, there is no significant effect on knowledge or skill retention over a 6-month period. Programs faced with the potential for in-person closures can select either semester structure based on their needs without compromising knowledge or skill retention.
Assessing Effectiveness of Physical Therapy Clinical Education Site Visits: Clinical Instructor and Student Perspectives
Authors: Lewis Michele (Shelly) , Lesser Melissa , Folkins Eric 
Published: May 2023

Introduction.
Video, phone, or in-person site visits are used to assess clinical education in entry-level physical therapy education programs. The perspectives of students and clinical instructors (CIs) related to site visits were examined in this article using 2 consecutive surveys. The first included items related to in-person and phone call site visits. The second added video calls. The research purpose was to assess the CI and student perspectives on the effectiveness of site visits and explore the differences between in-person, video, and phone visits.

Review of Literature.
Published literature about the effectiveness of site visits is scarce. Two recent articles explored the director of clinical education and student perspectives of site visits. Future research concentrating on the clinician perspective of site visits was recommended.

Subjects.
A convenience sample of 104 CIs and 97 doctor of physical therapy students were recruited by email for the 2 surveys.

Methods.
A mixed-methods, triangular, validating, quantitative data model was used. Respondents answered open-ended questions and rated items on 5-point Likert scales. Descriptive and chi-square statistics were calculated, and themes were developed using qualitative analysis.

Results.
No significant difference was found in preference of site visit method between students and CIs. CIs rated the effectiveness of site visits similarly for all methods. Students rated in-person site visits as the most effective in the first survey and video calls as the most effective in the second survey. Qualitative analysis showed that CIs and students preferred in-person visits when the student was struggling. Considering closed-ended and open-ended questions on both surveys, CIs and students would rather meet individually with the faculty member.

Discussion and Conclusion.
The results of this study suggest that any type of site visit can be effective; in-person visits should be considered when students are struggling, and the site visitor should meet privately with the student and CI.
Presence of Alpha 1 Antitrypsin Risk Variants is Not Associated With Histologic Severity of Pediatric NAFLD
Authors: Khan Maya , Klepper Corie , Orkin Sarah , Arce-Clachar Ana Catalina , Bramlage Kristen , Fei Lin , Miethke Alexander , Kohli Rohit , Xanthakos Stavra , Mouzaki Marialena 
Published: May 2023

Background:
Among adults with nonalcoholic fatty liver disease (NAFLD), alpha-1-antitrypsin (A1AT) heterozygosity has been linked to advanced liver disease; pediatric data remain unclear.

Objective:
The objective of this study is to determine whether A1AT PiZ or PiS variants are associated with liver disease severity in youth with NAFLD.

Methods:
Retrospective study of youth with confirmed NAFLD. Multivariable logistic regression used to determine independent associations between A1AT risk variants and histologic severity [NAFLD activity score (NAS) ≥5 and/or significant fibrosis (stage ≥2)].

Results:
The cohort included 269 patients, mean age 12 [±3] years with NAFLD and A1AT phenotyping (n = 260) and/or A1AT levels (n = 261). The mean NAS of the cohort was 4.2 [±1.5]; 50% had any, and 18% had significant fibrosis. Most (86%) had the MM A1AT phenotype, while 7% had the MS and 3% the MZ phenotype (the rest had other, nonpathogenic variants). Mean A1AT level was 123 mg/dL [±20]. A1AT levels did not differ by low versus high NAS (122 ± 2 vs 126 ± 19 mg/dL, P = 0.12) or by no/mild versus significant fibrosis (123 ± 20 vs 126 ± 20 mg/dL, P = 0.23, respectively). Carriers and noncarriers of the PiS or PiZ variants had similar NAS (mean NAS 3.8 ± 1.6 vs 4.2 ± 1.4; P = 0.25, respectively). Fibrosis severity did not differ by carrier vs noncarrier group: 38% versus 52% had any fibrosis (P = 0.17) and 14% versus 18% had significant fibrosis (P = 0.80, respectively). Multivariable modeling showed no association between A1AT risk variants and histologic severity.

Conclusion:
While not uncommon, carriage of the A1AT PiZ or PiS risk variants was not associated with histologic severity in children with NAFLD.