bluuebunny/crossref_metadata_2025_split huggingface dataset:
Self-reported life-space mobility in the first year after ischemic stroke: longitudinal findings from the MOBITEC-Stroke project
Authors: Hinrichs Timo , Rössler Roland , Infanger Denis , Weibel Robert , Schär Janine , Peters Eva-Maria , Portegijs Erja , Rantanen Taina , Schmidt-Trucksäss Arno , Engelter Stefan T. , Peters Nils 
Published: May 2023

AbstractBackgroundLife-space mobility is defined as the size of the area in which a person moves about within a specified period of time. Our study aimed to characterize life-space mobility, identify factors associated with its course, and detect typical trajectories in the first year after ischemic stroke.MethodsMOBITEC-Stroke (ISRCTN85999967; 13/08/2020) was a cohort study with assessments performed 3, 6, 9 and 12 months after stroke onset. We applied linear mixed effects models (LMMs) with life-space mobility (Life-Space Assessment; LSA) as outcome and time point, sex, age, pre-stroke mobility limitation, stroke severity (National Institutes of Health Stroke Scale; NIHSS), modified Rankin Scale, comorbidities, neighborhood characteristics, availability of a car, Falls Efficacy Scale-International (FES-I), and lower extremity physical function (log-transformed timed up-and-go; TUG) as independent variables. We elucidated typical trajectories of LSA by latent class growth analysis (LCGA) and performed univariate tests for differences between classes.ResultsIn 59 participants (mean age 71.6, SD 10.0 years; 33.9% women), mean LSA at 3 months was 69.3 (SD 27.3). LMMs revealed evidence (p ≤ 0.05) that pre-stroke mobility limitation, NIHSS, comorbidities, and FES-I were independently associated with the course of LSA; there was no evidence for a significant effect of time point. LCGA revealed three classes: “low stable”, “average stable”, and “high increasing”. Classes differed with regard to LSA starting value, pre-stroke mobility limitation, FES-I, and log-transformed TUG time.ConclusionRoutinely assessing LSA starting value, pre-stroke mobility limitation, and FES-I may help clinicians identify patients at increased risk of failure to improve LSA.
New method of remnant closure during distal pancreatectomy
Authors: Kelemen D. , Kerbeche A. , Farkas N. , Vereczkei A. 
Published: May 2023

Abstract

Purpose
Pancreatic fistula following distal pancreatectomies still remains a relevant problem. The present study describes our first series with a new method of pancreatic remnant closure.

Methods
A free fascia-peritoneum graft — harvested from the internal rectus sheet — was fixed onto the pancreatic stump by one circular stitch. The method was applied in 18 cases.

Results
The postoperative hospital stay was 8 days in average. No clinically relevant postoperative pancreatic fistula (CR-POPF) developed. The morbidity rate was 39%, mostly Clavien-Dindo Grade II types. There was no reoperation or mortality.

Conclusion
The first series showed advantageous results with our method. Certainly, further studies are needed for the evaluation of this new and promising technique.
Shaping the course of early-onset Parkinson’s disease: insights from a longitudinal cohort
Authors: Bovenzi Roberta , Conti Matteo , Degoli Giulia Rebecca , Cerroni Rocco , Simonetta Clara , Liguori Claudio , Salimei Chiara , Pisani Antonio , Pierantozzi Mariangela , Stefani Alessandro , Mercuri Nicola Biagio , Schirinzi Tommaso 
Published: May 2023

Abstract
Introduction
Early
-onset Parkinson’s disease (EOPD) labels those cases with onset earlier than fifty. Although peculiarities emerged either in clinical or pathological features, EOPD is managed alike typical, late-onset PD. A customized approach would be, instead, better appropriate. Accordingly, a deeper characterization of the clinical course, with an estimation of the disease progression rate, the therapy flow, and the main motor and non-motor complications occurrence, is needed.

Methods
A longitudinal cohort of 193 EOPD patients (selected on a single-centre population of 2000 PD cases) was retrospectively analysed, providing descriptive statics on a series of clinical parameters (genetics, phenotype, comorbidities, therapies, motor and non-motor complications, marital and gender issues) and modelling the trajectories from diagnosis to 10 years later of both Hoehn and Yahr (H&Y) stage and levodopa equivalent daily dose (LEDD).

Results
EOPD had a prevalence of 9.7%, including few monogenic cases. It mostly appeared as a motor syndrome, with asymmetric, rigid-akinetic presentation. H&Y linearly progressed with an increment of 0.92 points/10 years; LEDD flow had a non-linear trend, increasing of 526.90 mg/day in 0–5 years, and 166.83 mg/day in 5–10 years. Motor fluctuations started 6.5 ± 3.2 years from onset, affecting up to 80% of the cohort. Neuropsychiatric troubles interested the 50%, sexual complaints the 12%. Gender-specific motor disturbances emerged.

Conclusion
We shaped EOPD course, modelling a “brain-first” PD subtype, slowly progressive, with non-linear dopaminergic requirement. Major burden mostly resulted from motor fluctuations, neuropsychiatric complications, sexual and marital complaints, with a considerable gender-effect.
Obstacles to the diffusion of adaptation in the Rhein-Neckar region in Germany
Authors: Schmidt Nicole M. , Wagner Madeleine 
Published: May 2023

AbstractBecause the impacts of climate change are felt at the local level, we assess adaptation diffusion mechanisms (i.e., learning, competition, and emulation) among smaller big cities and medium-sized towns. Since the diffusion of adaptation has immediate spatial implications, we argue that local conditions play an important role in the diffusion process. The densely populated Rhein-Neckar Metropolitan Region in Germany is an ideal case for studying diffusion mechanisms with regard to adaptation. Using a rich data set of 28 interviews, we unpack the views of local actors such as mayors, city council politicians, city administration representatives, and representatives from regional agencies and identify factors influencing the diffusion of adaptation. We find limited or compromised diffusion due to insufficient knowledge about adaptation, competition between municipalities, and cooperation with cities outside the region. In addition, we find some (albeit limited) political will for adaptation. While some of the interviewed politicians considered making long-term investments in adaptation, most highlighted competing local issues and viewed adaptation with caution, illustrating adaptation’s lack of salience and social legitimacy. Indeed, one crucial finding was that housing and mobility are more important to a wide range of politicians and bureaucrats alike. By examining diffusion mechanisms at the subnational level, we combine theoretical perspectives from political science and geography to show how local decision-makers—in particular, politicians—influence the diffusion mechanisms of adaptation.
A high-throughput metabolomics in vitro platform for the characterization of hepatotoxicity
Authors: Ramirez-Hincapie Sabina , Birk Barbara , Ternes Philipp , Giri Varun , Haake Volker , Herold Michael , Zickgraf Franziska Maria , Verlohner Andreas , Huener Hans-Albrecht , Kamp Hennicke , Driemert Peter , Landsiedel Robert , Richling Elke , Funk-Weyer Dorothee , van Ravenzwaay Bennard 
Published: May 2023

AbstractCell-based metabolomics provides multiparametric physiologically relevant readouts that can be highly advantageous for improved, biologically based decision making in early stages of compound development. Here, we present the development of a 96-well plate LC-MS/MS-based targeted metabolomics screening platform for the classification of liver toxicity modes of action (MoAs) in HepG2 cells. Different parameters of the workflow (cell seeding density, passage number, cytotoxicity testing, sample preparation, metabolite extraction, analytical method, and data processing) were optimized and standardized to increase the efficiency of the testing platform. The applicability of the system was tested with seven substances known to be representative of three different liver toxicity MoAs (peroxisome proliferation, liver enzyme induction, and liver enzyme inhibition). Five concentrations per substance, aimed at covering the complete dose-response curve, were analyzed and 221 uniquely identified metabolites were measured, annotated, and allocated in 12 different metabolite classes such as amino acids, carbohydrates, energy metabolism, nucleobases, vitamins and cofactors, and diverse lipid classes. Multivariate and univariate analyses showed a dose response of the metabolic effects, a clear differentiation between liver toxicity MoAs and resulted in the identification of metabolite patterns specific for each MoA. Key metabolites indicative of both general and mechanistic specific hepatotoxicity were identified. The method presented here offers a multiparametric, mechanistic-based, and cost-effective hepatotoxicity screening that provides MoA classification and sheds light into the pathways involved in the toxicological mechanism. This assay can be implemented as a reliable compound screening platform for improved safety assessment in early compound development pipelines.
Graphical abstract
Generalized $$\mathbb {XOR}$$ Operation and the Categorical Equivalence of the Abbott Algebras and Quantum Logics
Authors: Burešová Dominika 
Published: May 2023

AbstractConsidering the inference rules in generalized logics, J.C. Abbott arrives to the notion of orthoimplication algebra (see Abbott (1970) and Abbott (Stud. Logica. 2:173–177, XXXV)). We show that when one enriches the Abbott orthoimplication algebra with a falsity symbol and a natural $$\mathbb {XOR}$$
XOR
-type operation, one obtains an orthomodular difference lattice as an enriched quantum logic (see Matoušek (Algebra Univers. 60:185–215, 2009)). Moreover, we find that these two structures endowed with the natural morphisms are categorically equivalent. We also show how one can introduce the notion of a state in the Abbott $$\mathbb {XOR}$$
XOR
algebras strenghtening thus the relevance of these algebras to quantum theories.
Recirculating packed-bed biofilm photobioreactor combined with membrane ultrafiltration as advanced wastewater treatment
Authors: Díaz Oliver , González Enrique , Vera Luisa , Fernández Luis Javier , Díaz-Marrero Ana R. , Fernández José J. 
Published: May 2023

AbstractPacked-bed biofilm photobioreactor combined with ultrafiltration membrane was investigated for intensifying the process for secondary wastewater effluent treatment. Cylindrical glass carriers were used as supporting material for the microalgal-bacterial biofilm, which developed from indigenous microbial consortium. Glass carriers allowed adequate growth of the biofilm with limited suspended biomass. Stable operation was achieved after a start-up period of 1000 h, where supernatant biopolymer clusters were minimized and complete nitrification was observed. After that time, biomass productivity was 54 ± 18 mg·L−1·day−1. Green microalgae Tetradesmus obliquus and several strains of heterotrophic nitrification–aerobic denitrification bacteria and fungi were identified. Combined process exhibited COD, nitrogen and phosphorus removal rates of 56 ± 5%, 12 ± 2% and 20 ± 6%, respectively. Membrane fouling was mainly caused by biofilm formation, which was not effectively mitigated by air-scouring aided backwashing.
Social Infrastructure and the Alleviation of Loneliness in Europe
Authors: Swader Christopher S. , Moraru Andreea-Valentina 
Published: May 2023

AbstractIn Europe, individualist societies, in which people more highly value independence, have fewer people who are lonely. Yet these societies also have more people who live alone, a strong determinant of loneliness. Evidence suggests that some unrecognized societal-level resources or characteristics can explain this.We uncover multiple pathways toward a lower degree of loneliness among European societies using an ideal method for this purpose, fuzzy-set qualitative comparative analysis. Using data from the 2014 wave of the European Social Survey and other sources, we analyzed loneliness outcomes among 26 European societies. Our findings suggest two necessary conditions for a low degree of loneliness: high internet access and high association participation. Further, three pathways are sufficient for achieving less loneliness at the societal level. Most societies that have less loneliness follow both the welfare support and cultural support pathways. The third path, commercial provision, is mutually exclusive with welfare support because the former requires a weak welfare state.The surest policy for building societies that have lower rates of loneliness includes the expansion of internet accessibility, the fostering of civil society through association participation and volunteering, and a welfare state that protects potentially vulnerable populations while funding opportunities for social interaction. This article further contributes methodologically by demonstrating “configurational robustness testing,” a more comprehensive means to implement current best practices for fuzzy-set qualitative comparative analysis robustness testing.
Bringing the Nature Futures Framework to life: creating a set of illustrative narratives of nature futures
Authors: Durán América Paz , Kuiper Jan J. , Aguiar Ana Paula Dutra , Cheung William W. L. , Diaw Mariteuw Chimère , Halouani Ghassen , Hashimoto Shizuka , Gasalla Maria A. , Peterson Garry D. , Schoolenberg Machteld A. , Abbasov Rovshan , Acosta Lilibeth A. , Armenteras Dolors , Davila Federico , Denboba Mekuria Argaw , Harrison Paula A. , Harhash Khaled Allam , Karlsson-Vinkhuyzen Sylvia , Kim HyeJin , Lundquist Carolyn J. , Miller Brian W. , Okayasu Sana , Pichs-Madruga Ramon , Sathyapalan Jyothis , Saysel Ali Kerem , Yu Dandan , Pereira Laura M. 
Published: May 2023

AbstractTo halt further destruction of the biosphere, most people and societies around the globe need to transform their relationships with nature. The internationally agreed vision under the Convention of Biological Diversity—Living in harmony with nature—is that “By 2050, biodiversity is valued, conserved, restored and wisely used, maintaining ecosystem services, sustaining a healthy planet and delivering benefits essential for all people”. In this context, there are a variety of debates between alternative perspectives on how to achieve this vision. Yet, scenarios and models that are able to explore these debates in the context of “living in harmony with nature” have not been widely developed. To address this gap, the Nature Futures Framework has been developed to catalyse the development of new scenarios and models that embrace a plurality of perspectives on desirable futures for nature and people. In this paper, members of the IPBES task force on scenarios and models provide an example of how the Nature Futures Framework can be implemented for the development of illustrative narratives representing a diversity of desirable nature futures: information that can be used to assess and develop scenarios and models whilst acknowledging the underpinning value perspectives on nature. Here, the term illustrative reflects the multiple ways in which desired nature futures can be captured by these narratives. In addition, to explore the interdependence between narratives, and therefore their potential to be translated into scenarios and models, the six narratives developed here were assessed around three areas of the transformative change debate, specifically, (1) land sparing vs. land sharing, (2) Half Earth vs. Whole Earth conservation, and (3) green growth vs. post-growth economic development. The paper concludes with an assessment of how the Nature Futures Framework could be used to assist in developing and articulating transformative pathways towards desirable nature futures.
Factors influencing patients’ experience of communication with the medical team of the emergency department
Authors: Degabriel Dea , Petrino Roberta , Frau Eleonora Dafne , Uccella Laura 
Published: May 2023

AbstractThe Emergency Department (ED) setting often presents situations where the doctor–patient relationship is fundamental and may be challenging. Thus, it is important to use effective communication to improve outcomes. This study explores patients’ experience of communication with the medical team aiming to discover whether there are some objective factors which may affect their perception. A prospective, cross-sectional study in two hospitals: an urban, academic trauma center and a small city hospital. Adult patients discharged from the ED in October 2021 were consecutively included. Patients filled out a validated questionnaire, the Communication Assessment Tool for Teams (CAT-T), assessing communication perception. Additional data about the participants were collected by the physician in a dedicated tab to assess whether there were objective factors influencing the patient’s perception of the medical team's communication skills. Statistical analysis was then performed. 394 questionnaires were analyzed. The average score for all items exceeded 4 (good). Younger patients and patients who were conveyed by ambulance attributed lower scores than other groups (p value < 0.05). A significant difference between the two hospitals was also observed in favour of the bigger hospital. In our study long waiting times did not generate less satisfied responses. The item which received the lowest scores was “the medical team encouraged me to ask questions”. Overall, patients were satisfied with doctor–patient communication. Age, setting, way of conveyance to the hospital are objective factors that may influence patients’ experience and satisfaction in the ED.
An Update on Appendiceal Neuroendocrine Tumors
Authors: Andrini Elisa , Lamberti Giuseppe , Alberici Laura , Ricci Claudio , Campana Davide 
Published: May 2023

AbstractThe mainstay of appendiceal neuroendocrine neoplasm (aNEN) treatment is surgery, based on simple appendectomy or right-sided hemicolectomy with lymphadenectomy (RHC). The majority of aNENs are adequately treated with appendectomy, but current guidelines have poor accuracy in terms of selecting patients requiring RHC, especially in aNENs 1–2 cm in size. Simple appendectomy is curative for appendiceal NETs (G1–G2) < 1 cm (if the resection status is R0), whereas RHC with lymph node dissection is recommended in tumors ≥ 2 cm in diameter, based on the high risk of nodal metastases in these cases. The clinical management of aNENs 1–2 cm in size is more controversial because lymph node or distant metastases are uncommon but possible. In our opinion, patients with tumor size > 15 mm or with grading G2 (according to WHO 2010) and/or lympho-vascular invasion should be referred for radicalization with RHC. However, decision-making in these cases should include discussion within a multidisciplinary tumor board at referral centers with the aim of offering each patient a tailored treatment, also considering that relatively young patients with long-life expectancy represent the majority of cases.
Subgroup specific relations between the goal-striving reasons framework and subjective well-being
Authors: Ehrlich Christian , Milston Sashenka 
Published: May 2023

Abstract
People’s reasons for goal pursuit strongly relate to well-being. An important concept that captures differences in the reasons for goal pursuit is the goal-striving reasons framework. Until today, it remains unclear whether the goal-striving reasons framework relates differently to the well-being of particular groups of people. Using the positive-activity model as a guiding framework, the paper at hand analyses a number of person-related characteristics which are relevant in a goal-setting context and are assumed to change the relationship between goal-striving reasons and well-being. Employing a large cumulative data set the person-related characteristics comprise of demographic variables (age, gender, managerial status) and selected well-being related variables (assertiveness, burnout, engagement, goal progress). Using correlation analyses in conjunction with Fisher’s z-test the results show that contrary to older employees (aged 24 or older) the goal-striving reasons of younger people are not related to their well-being. Women’s self-esteem reasons are more strongly related to well-being than they are for men. People’s goal-striving reasons are more strongly associated with well-being for people with high levels of assertiveness, low levels of burnout, or high levels of engagement. The findings have implications for the delivery of the Happiness through Goal Setting Training, a Positive Psychology Intervention based on the goal-striving reasons framework, as it identifies various alterations of the training to cater for the needs of these subgroups.
Kwaliteitsverbetering als een gezamenlijke opgave
Authors: Naber Juultje , Reijmer Yael , van den Berg Bellis 
Published: May 2023

SamenvattingOm de implementatie van het Kwaliteitskader Verpleeghuiszorg in de praktijk te bevorderen startte het ministerie van Volksgezondheid, Welzijn en Sport (VWS) in 2019 in samenwerking met kennisorganisatie Vilans het ondersteuningsprogramma Waardigheid en trots op locatie. Verpleeghuislocaties die deelnemen aan dit programma starten met een Scan Kwaliteitskader Verpleeghuiszorg (scan KKV), die in kaart brengt wat de kwaliteit van zorg is ten opzichte van het kwaliteitskader en welke verbeterpunten aandacht behoeven. Dit artikel beschrijft de werkzame elementen van deze scan en de geleerde lessen.
Estimating Probabilities of Extreme ENSO Events from Copernicus Seasonal Hindcasts
Authors: Merryfield William J. , Lee Woo-Sung 
Published: May 2023

AbstractMulti-system seasonal hindcasts supporting operational seasonal forecasts of the Copernicus Climate Change Service (C3S) are examined to estimate probabilities that El Niño and La Niña episodes more extreme than any in the reliable observational record could occur in the current climate. With 184 total ensemble members initialized each month from 1993 to 2016, this dataset greatly multiplies the realizations of ENSO variability during this period beyond the single observed realization, potentially enabling a detailed assessment of the chances of extreme ENSO events. The validity of such an assessment is predicated on model fidelity, which is examined through two-sample Cramér–von Mises tests. These do not detect differences between observed and modeled distributions of the Niño 3.4 index once multiplicative adjustments are applied to the latter to match the observed variance, although differences too small to be detected cannot be excluded. Statistics of variance-adjusted hindcast Niño 3.4 values imply that El Niño and La Niña extremes exceeding any that have been instrumentally observed would be expected to occur with a > 3% chance per year on average across multiple realizations of the hindcast period. This estimation could also apply over the next several decades, provided ENSO variability remains statistically similar to the hindcast period.