bluuebunny/crossref_metadata_2025_split huggingface dataset:
On modelling of surface tension of CMC‐α‐Fe2O3 nanoparticles by fuzzy‐hybrid approach: A comparison study
Authors: Gonce Kocken Hale , Insel Mert Akin , Temelcan Gizem , Karakuş Selcan , Albayrak Inci 
Published: February 2023

AbstractSurface tension is one of the most important rheological parameters of nanoliquids. It influences the thermophysical and mass transfer properties of nanostructures. Accurate estimation of the surface tension from operating variables is critical for determining optimal production processes. However, the challenges of producing nanoparticles and measuring their properties introduce experimental errors in the data used for mathematical modelling. Crisp regression approaches provide adequate representation of the data, but they do not provide information about the experimental uncertainty. In this study, a fuzzy‐hybrid approach is proposed for mathematical modelling of surface tension of carboxymethyl cellulose/chitosan‐α‐Fe2O3 nanoparticles. Then, the proposed model is compared with a crisp model from a previous study. Error analysis is conducted to validate the constructed fuzzy model. It is observed that the fuzzy‐hybrid modelling approach has yielded significantly lower error values (a 60%–90% improvement in all error metrics on average), and thus, it is superior to the crisp approach. This study contributes to the subject of modelling rheological properties. It is shown that the fuzzy‐hybrid approach has impressive potential to be utilized for modelling the rheological properties of nanostructures.
How Doping Affects the Activity of the Aluminum Oxide Support
Authors: Yan Linghui , Qian Chao , Zhou Shaodong 
Published: February 2023

AbstractThe performance of heteronuclear clusters [AlXO3]+ (X=Al, AlO4, AlMg2O2, AlZnO, AlAu2, Mg, Y, VO, NbO, TaO) in activating methane has been explored by a combination of high–level quantum calculations with reported and supplementary gas‐phase experiments. With different dopants in [AlXO3]+, the mechanism, reactivity and selectivity towards methane activation varies accordingly. The classic HAT competes with PCET, depending on the composition of intramolecular interactions. Although the existence of terminal oxygen radical is beneficial for classic HAT, the Alt−C interaction in the [AlXO3]+ clusters as enhanced by the strongly electronegative doping groups (X=Al, AlZnO, Mg, Zn, VO, NbO, TaO) favors the PCET process, facilitating C−H bond breaking. In addition, with different dopants, the destiny of the split methyl group varies accordingly. While strong interaction between Alt and CH3 results in the formation of the Alt−C bond, dopants with variable valance may promote the formation of deep‐oxidation products like formaldehyde. It has been discussed in detail how to regulate the activity and selectivity of the active center of the catalyst via rational doping.
Expression of stay‐green drought tolerance in dhurrin‐free sorghum
Authors: Gruss Shelby M. , Souza Augusto , Yang Yang , Dahlberg Jeff , Tuinstra Mitchell R. 
Published: February 2023

AbstractSorghum (Sorghum bicolor (L) Moench) is naturally adapted to water‐limited environments. Dhurrin is a secondary metabolite that is proposed to play a key role in the expression of stay‐green drought tolerance of sorghum. In this study, a genetic mutation in CYP79A1, the first enzyme in the biosynthetic pathway of dhurrin, was used to study the role of dhurrin accumulation in stay‐green drought tolerance of sorghum. The cyp79a1 mutation inhibits the production of dhurrin. Near‐isogenic lines (NILs), near‐isogenic backcross (NIBC) populations, and near‐isogenic hybrids (NIHs) were evaluated for variation in stay‐green drought tolerance in controlled environments and field trials. Chlorophyll concentration (CC) and normalized difference vegetation index (NDVI) were measured to quantify variation in stay‐green among genotypes. Comparisons of NILs of Tx623 bmr6 and NIBC progeny from the stay‐green donor Tx642 indicated differences in CC and NDVI between plants in the drought and irrigated treatments but no significant differences between NILs and NIBC within treatments (p < 0.05). Analyses of NIHs in a controlled environment and field trials demonstrated similar patterns although there was one set of NIHs that exhibited variation in the field trials. The NIHs carrying the cyp79a1 mutation exhibited reduced CC in comparison to the wild‐type plants in the drought treatments (p < 0.05). These studies indicated that dhurrin production may contribute to the expression of stay‐green, but the effects are generally small and genotype specific.
One‐Pot Synthesis of 2D‐2D WO3/g‐C3N4 Photocatalyst in Reverse Microemulsion System via Supercritical CO2 for Enhanced Hydrogen Generation
Authors: Tang Shaoru , Ma Yanan , Wang Haimeng , Liang Yuxuan , Xu Xiaoyang , Zhang Dingyu , Cao Beiming , Wang Qian , Li Wei 
Published: February 2023

AbstractConstruction of Z‐scheme photocatalyst is an effective approach for using solar energy to produce hydrogen during water splitting. Herein, 2D/2D WO3/g‐C3N4 heterojunction photocatalyst was synthesized by a convenient and green method including exfoliation and heterojunction procedures, in the reverse microemulsion system via supercritical carbon dioxide (scCO2). The resultant W/CN‐10.3 composite exhibited enhanced photocatalytic activities towards the hydrogen evolution during water splitting with a hydrogen evolution rate of 688.51 μmol g−1 h−1, which was more than 16 times higher than bulk g‐C3N4 with the same loading amount of Pt as cocatalyst. Due to its effective separation of photogenerated carriers and prolonged lifetime, more photoexcited electrons with high reduction ability could contribute to the production of H2. Possible formation mechanism of 2D‐2D WO3/g‐C3N4 nanosheets via scCO2 in the reverse microemulsion system by the one‐pot method has been proposed. This work provides an efficient and green strategy to synthesize 2D‐2D heterojunction for the utilization in solar‐to‐fuel conversion.
A low output ripple and high security on‐chip voltage regulation based on Fourier transform
Authors: Cheng Jiafeng , Liu Wenrui , Sun Nengyuan , Peng Zhaokang , Sun Caiban , Wang Chunyang , Bi Yijian , Wen Yiming , Zhang Hongliu , Zhang Pengcheng , Yu Weize 
Published: February 2023

SummaryIn modern integrated circuits (ICs), integrating workload‐agnostic multiphase switched‐capacitor (SC) voltage converters on‐chip is an effective way to reduce the transient response time, improve the security, and boost the power efficiency. However, a stochastic and unbalanced active sequence within the multiphase SC converter may undermine the corresponding output voltage ripple significantly. In this paper, a novel algorithm that is based on Fourier transform is capable of efficiently mitigating the amplitude of output ripple without compromising its security drastically. To achieve this objective, firstly, the output ripple of a single‐phase SC converter needs to be approximated with a Fourier expansion. Then the relationship between the output ripple and active phase sequence of a multiphase SC converter can be modeled precisely under the assistance of Fourier transform. After maximizing the randomness of the active sequences of the multiphase SC converter under different workload conditions and filtering a certain number of phase sequences with unsatisfied output ripples, the optimum control algorithm is generated. As shown in the result, the amplitude of output ripple of a multiphase SC converter can be reduced by 69.5% with negligible security loss and less than 29% power and area overhead under the 55 nm process design kits (PDK).
Highly Selective and Practical Iron‐Catalyzed Formal Hydrogenation of Epoxides to Primary Alcohols Using Formic Acid
Authors: Yao Yi‐Xuan , Zhang Hong‐Wei , Lu Chang‐Bo , Shang Hong‐Yan , Tian Yuan‐Yu 
Published: February 2023

AbstractA highly selective, efficient and practical method for synthesizing primary alcohols was presented. By using cheap Fe(BF4)2 ⋅ 6H2O and /tris[2‐(diphenylphosphino)phenyl]phosphine (L1) as catalysts with formic acid as hydrogen source, a variety of primary alcohols bearing versatile functional groups could be obtained from both alkyl‐ and aryl‐substituted epoxides under mild conditions.
Ionic Liquid Crystalline Calixarene with Photo‐Switchable Proton Conduction
Authors: Concellón Alberto , Marín Iván , Barberá Joaquín , Marcos Mercedes , Serrano José L. 
Published: February 2023

AbstractWe have developed a new strategy for the preparation of a light‐responsive ionic liquid crystal (LC) that shows photo‐switchable proton conduction. The ionic LC consists of a bowl‐shaped calix[4]arene core ionically functionalized with azobenzene moieties. The non‐covalent architectures were obtained by the formation of ionic salts between the carboxylic acid group of an azo‐derivative and the terminal amine groups of a calixarene core. The presence of ionic salts results in a hierarchical self‐assembly process that extends to the formation of a nanostructured lamellar LC arrangement (smectic A phase). In this LC phase, the ionic LC calixarene is able to display proton conductive properties, since the ionic nanosegregated areas (formed by the ionic pairs) generate the continuous channels that favor proton transport. The optical and photo‐responsive properties were studied by UV‐Vis spectroscopy, demonstrating that the azobenzene moieties of the ionic LC undergo reversible (E)‐to‐(Z) isomerization by irradiation with UV light. Interestingly, this (E)‐to‐(Z) photoisomerization results in a decrease of the proton conductivity values since the bent‐shaped (Z)‐isomer disrupts the lamellar LC phase. This isomerization process is totally reversible and leads to an ionic LC material with unique photo‐switchable proton conductive properties.
Fetal neurosonography in pregnant women recovering from COVID‐19 disease
Authors: Akgün Aktas Betül , Kaya Ecem , Laleli Koc Bergen , Turgut Ezgi , Tanacan Atakan , Sahin Dilek 
Published: February 2023

AbstractObjectiveTo investigate the effect of severe acute respiratory virus 2 (SARS‐CoV‐2) on fetal neurodevelopment in pregnant women.MethodsThis prospective cohort study included 54 pregnant women at least 4 weeks after the SARS‐CoV‐2 infection and 58 controls. In the third trimester, the depths of the fetal insula, Sylvian, parieto‐occipital, and calcarine fissures, the length of cavum septum pellucidum (CSP), and the thickness of the corpus callosum (CC) were measured. Sylvian fissure operculization and cortical development were graded. The correlation analysis between fetal cortical development and Sylvian fissure operculization was performed with the Pearson test.ResultsThe calcarine fissure depth and CC thickness were reduced in the study group (P < 0.001, P = 0.004). The fetal CSP length and ratio were increased in the study group (P = 0.016, P = 0.039). Approximately half of the study group fetuses had grade 4 or less Sylvian fissure operculization. The study group had a significantly higher rate of fetuses with grade 2 (31.5% vs. 13.8%) and significantly lower rate of fetuses with grade 4 cortical development (14.8% vs. 31.0%), compared with the controls. There was a moderate negative significant correlation between pregnant women recovering from COVID‐19 and fetal cortical development and Sylvian fissure operculization (P = 0.001).ConclusionThis is the first study to investigate fetal cortical development in pregnant women recovering from COVID‐19. The results indicate that COVID‐19 disease may affect fetal neurodevelopment.
Dual process in parent–adolescent moral socialization: The moderating role of maternal warmth and involvement
Authors: Kil Hali , Gath Megan , Grusec Joan E. 
Published: February 2023

AbstractIntroductionIt has been argued that moral identity can be conceptualized as implicit and automatic or explicit and controlled dualities of cognitive information processing. In this study, we examined whether socialization in the moral domain may also exhibit a dual process. We further tested whether parenting that is warm and involved may play a moderating role in moral socialization. We assessed relations between mothers' implicit and explicit moral identity, warmth and involvement, and the prosocial behavior and moral values of their adolescent children.MethodsParticipants were 105 mother–adolescent dyads from Canada, with adolescents between 12 and 15 years of age and 47% girls. Mothers' implicit moral identity was measured using the Implicit Association Test (IAT), adolescents' prosocial behavior was measured using a donation task, and the remaining mother and adolescent measures were self‐reported. Data were cross‐sectional.ResultsWe found that mothers' implicit moral identity was associated with adolescents' greater generosity during the prosocial behavior task, but only when mothers were warm and involved. Mothers' explicit moral identity was associated with adolescents' more prosocial values.ConclusionsMoral socialization may occur through dual processes, and as an automatic process may only take place when mothers are also high in warmth and involvement, setting the conditions for adolescents' understanding and acceptance of the moral values being taught and ultimately their automatic morally relevant behaviors. Adolescents' explicit moral values, on the other hand, may be aligned with more controlled, reflective socialization processes.
3D printable phantom for mimicking electrical properties of dermal tissue
Authors: Kuzemchak Blake C. , Choe Robert H. , Sherry Mary , Porter Emily , Fisher John P. 
Published: February 2023

AbstractSkin cancer is one of the most ubiquitous forms of cancer that is often overdiagnosed or missed by traditional diagnostic techniques. Bioimpedance spectroscopy (BIS) is a technology that aims to take advantage of the variations in electrical properties of tissue to identify ectopic formations. It is difficult to develop BIS technologies without obtaining tumor tissue samples. One solution is to use a “tissue phantom,” a synthetic structure that mimics the properties of tissue. Current solutions using natural biomaterials, such as gelatin, have not been able to create complex tissue geometries that are vital to honing BIS diagnostics. However, semi‐synthetic polymers, such has gelatin methacrylate (GelMA), offer the benefits of possessing similar electrical properties to their respective source biomaterial while being 3D printable. In this work, we first measured the impedance of porcine dermal tissue. We then applied these impedance measurements to create an electrically accurate tissue phantom using a photocurable hydrogel, GelMA, and varying concentrations of NaCl, aluminum powder, and titanium dioxide powder.
In‐silico structural characterization and phylogenetic analysis of Nucleoside diphosphate kinase: A novel antiapoptotic protein of Porphyromonas gingivalis
Authors: Singh Suchitra , Yadav Piyush Kumar , Singh Ajay Kumar 
Published: February 2023

AbstractThe Nucleoside diphosphate kinase (NDK) protein of Porphyromonas gingivalis (P. gingivalis) plays a crucial role in immune evasion and inhibition of apoptosis in host cells and has the potential to cause cancer. However, its structure has not yet been characterized. We used an in‐silico approach to determine the 3D structure of the P. gingivalis NDK. Furthermore, structural characterization and functional annotation were performed using computational approaches. The 3D structure of NDK was predicted through homology modeling. The structural domains predicted for the model protein belong to the NDK family. Structural alignment of prokaryotic and eukaryotic NDKs with the model protein revealed the conservation of the domain region. Structure‐based phylogenetic analysis depicted a significant evolutionary relationship between the model protein and the prokaryotic NDK. Functional annotation of the model confirmed structural homology, exhibiting similar enzymatic functions as NDK, including ATP binding and nucleoside diphosphate kinase activity. Furthermore, molecular dynamic (MD) simulation technique stabilized the model structure and provides a thermo‐stable protein structure that can be used as a therapeutic target for further studies.
Chaperone‐mediated autophagy degrade Dicer to promote breast cancer metastasis
Authors: Su Chih‐Ming , Hsu Tung‐Wei , Chen Hsin‐An , Wang Wan‐Yu , Huang Chih‐Yang , Hung Chih‐Chiang , Yeh Ming‐Hsin , Su Yen‐Hao , Huang Ming‐Te , Liao Po‐Hsiang 
Published: February 2023

AbstractMetastasis in breast cancer usually lead to the majority of deaths on clinical patients. Accordingly, diagnosis of metastasis at the early stage in breast cancer is important to improve the prognosis. We observed that Dicer protein levels are significant decrease in highly invasive breast cancer cells and usually correlated with poor clinical outcomes. Following, we aim to clarify the molecular regulatory mechanism of this phenomenon in breast cancer to provide a new therapeutic target. In this study, we obtained that Dicer expression correlated with metastasis and invasion without affect cell stability in breast cancer cells. Importantly, we identified the regulatory mechanism of Dicer protein degradation, the chaperone‐mediated autophagy (CMA)‐mediated degradation that is major mechanism to decrease Dicer protein expression and lead to cancer metastasis. We discovered that heat shock cognate 71‐kDa protein (Hsc70) which as a CMA‐related factor interacts with the CMA‐targeting motif I333A/K334A on Dicer to promote degradation through CMA. Taken together, our findings hint that Dicer highly correlated with cancer metastasis, we reveal the tumor‐promoting effect of CMA‐mediated Dicer degradation in breast cancer.
A glycosylation signature for predicting the progression and immunotherapeutic response of prostate cancer
Authors: Sun Kailun , Feng Zhaoyan , Fan Chanyuan , Min Xiangde , Zhang Peipei , Xia Liming 
Published: February 2023

AbstractBackgroundGlycosylation has been proposed as a new cancer hallmark. However, focusing on specific glycans or glycoproteins may lose much data relevant to glycosylation alterations. The present study aimed to first comprehensively investigate the expression and mutation profiles of glycosylation‐related genes (GRgenes) in prostate cancer (PCa) and then develop a glycosylation signature and explore its role in predicting the progression and immunotherapeutic response of PCa.MethodsBased on The Cancer Genome Atlas database, we comprehensively screened potential prognostic GRgenes and analyzed their expression and mutation profiles in PCa. Through consensus clustering analysis, the study cohort was classified to investigate the effect of glycosylation patterns on the prognosis of PCa. Next, we developed a glycosylation signature (i.e., the glycosylation score [Gly_score]) using the differentially expressed genes between glycosylation pattern groups and evaluated its role in predicting the progression and immunotherapeutic response of PCa.ResultsWe identified two distinct glycosylation patterns in PCa and found that GRgene expression patterns rather than mutations are associated with the prognosis of PCa. The high Gly_score group had significantly shorter progression‐free survival, lower PD‐L1 levels, less infiltration of immune cells and lower immunophenoscores than the low Gly_score group. When the patients were grouped according to both the Gly_score and PD‐L1 level, patients with a combination of low Gly_score and low PD‐L1 expression had the best survival outcomes.ConclusionsIn the present study, for the first time, we developed a glycosylation signature and demonstrated that the proposed glycosylation signature is a promising tool for predicting the prognosis and immunotherapeutic response of PCa.
Epidemiology of herpes simplex virus type 2 in the Middle East and North Africa: Systematic review, meta‐analyses, and meta‐regressions
Authors: Harfouche Manale , Alareeki Asalah , Osman Aisha M. M. , Alaama Ahmed S. , Hermez Joumana G. , Abu‐Raddad Laith J. 
Published: February 2023

AbstractHerpes simplex virus type 2 (HSV‐2) infection is a prevalent, sexually transmitted infection with poorly characterized prevalence in the Middle East and North Africa (MENA) region. This study characterized HSV‐2 epidemiology in MENA. HSV‐2 reports were systematically reviewed as guided by the Cochrane Collaboration Handbook and findings were reported following PRISMA guidelines. Random‐effects meta‐analyses and meta‐regressions were performed to estimate pooled mean outcome measures and to assess predictors of HSV‐2 antibody prevalence (seroprevalence), trends in seroprevalence, and between‐study heterogeneity. In total, sixty‐one overall (133 stratified) HSV‐2 seroprevalence measures and two overall (four stratified) proportion measures of HSV‐2 detection in laboratory‐confirmed genital herpes were extracted from 37 relevant publications. Pooled mean seroprevalence was 5.1% (95% confidence interval [CI]: 3.6%–6.8%) among general populations, 13.3% (95% CI: 8.6%–18.7%) among intermediate‐risk populations, 20.6% (95% CI: 5.3%–42.3%) among female sex workers, and 18.3% (95% CI: 3.9%–39.4%) among male sex workers. Compared to Fertile Crescent countries, seroprevalence was 3.39‐fold (95% CI: 1.86–6.20) and 3.90‐fold (95% CI: 1.78–8.57) higher in Maghreb and Horn of Africa countries, respectively. Compared to studies published before 2010, seroprevalence was 1.73‐fold (95% CI: 1.00–2.99) higher in studies published after 2015. Pooled mean proportion of HSV‐2 detection in genital herpes was 73.8% (95% CI: 42.2%–95.9%). In conclusion, MENA has a lower HSV‐2 seroprevalence than other world regions. Yet, 1 in 20 adults is chronically infected, despite conservative prevailing sexual norms. Seroprevalence may also be increasing, unlike other world regions. Findings support the need for expansion of surveillance and monitoring of HSV‐2 infection in MENA.
Frequency evaluation and molecular characterization of HHV‐6 and HHV‐7 among children under 5 years with fever and skin rash
Authors: Keshavarz Mohsen , Ghasemi Somayeh , Arjeini Yaser , Namdari Haideh , Maleki Hassan , Mousavi Neda , Mokhtari‐Azad Talat , Rezaei Farhad 
Published: February 2023

AbstractSkin rash is one of the most common complications during childhood. Viral agents play an essential role in the development of such symptoms. Present study aims to determine the prevalence and genetic variability of Human Herpesvirus 6 and 7 (HHV‐6 and HHV‐7) infections and their subtypes in children under 5 years of age with skin rash and negative for rubella and measles. We used serum and throat swap samples from 196 children with skin rash and fever. ELISA and IFA tests were performed to detect antibodies against HHV6/7. Sequencing was performed using Sanger sequencing, and BioEdit and MEGA10 software were used for sequence analysis. According to the results, 66% and 40% of cases were positive for HHV‐6 IgM and HHV‐7 IgM, respectively. According to the molecular analysis, HHV‐6 Nested‐PCR was positive in 18% of cases, however, HHV‐7 Nested‐PCR was positive in 7.7% of cases. On the other hand, HHV‐6 IgG and HHV‐7 IgG were positive in 91% and 55% of study cases, respectively. For HHV‐6, we found some genetic variabilities resulting in antigenic changes compared to reference strains. HHV‐7 isolates showed no genetic differentiation and had a stable gene sequence. Based on the results, the detection of some cases of HHV6/7 primary infection and the presence of specific symptoms of roseola in the study population needs continuous evaluation of HHV6/7 frequency and distribution, also genetic variabilities of HHV6. This can pave the way for investigating HHV6 immune evasion and vaccine research and studying the relationship between viral genetic variations and other factors like disease severity. Furthermore, it is necessary to determine the relation between HHV6 genetic changes and latent infection to be considered in possible future vaccines and antiviral drug development.