bluuebunny/crossref_metadata_2025_split huggingface dataset:
Glycogen synthase GYS1 overactivation contributes to glycogen insolubility and malto-oligoglucan-associated neurodegenerative disease
Authors: Nitschke Silvia , Montalbano Alina P , Whiting Megan E , Smith Brandon H , Mukherjee-Roy Neije , Marchioni Charlotte R , Sullivan Mitchell A , Zhao Xiaochu , Wang Peixiang , Mount Howard , Verma Mayank , Minassian Berge A , Nitschke Felix 
Published: January 2025

Abstract
Polyglucosans are glycogen molecules with overlong chains, which are hyperphosphorylated in the neurodegenerative Lafora disease (LD). Brain polyglucosan bodies (PBs) cause fatal neurodegenerative diseases including Lafora disease and adult polyglucosan body disease (ABPD), for which treatments, biomarkers, and good understanding of their pathogenesis are currently missing. Mutations in the genes for the phosphatase laforin or the E3 ubiquitin ligase malin can cause LD. By depleting PTG, an activator of the glycogen chain-elongating enzyme glycogen synthase (GYS1), in laforin- and malin-deficient LD mice, we show that abnormal glycogen chain lengths and not hyperphosphorylation underlie polyglucosan formation, and that polyglucosan bodies induce neuroinflammation. We provide evidence indicating that a small pool of overactive GYS1 contributes to glycogen insolubility in LD and APBD. In contrast to previous findings, metabolomics experiments using in situ-fixed brains reveal only modest metabolic changes in laforin-deficient mice. These changes are not replicated in malin-deficient or APBD mice, and are not normalized in rescued LD mice. Finally, we identify a pool of metabolically volatile malto-oligoglucans as a polyglucosan body- and neuroinflammation-associated brain energy source, and promising candidate biomarkers for LD and APBD, including malto-oligoglucans and the neurodegeneration marker CHI3L1/YKL40.
RNA-binding proteins as versatile metabolic regulators
Authors: Koletsou Ellie , Huppertz Ina 
Published: January 2025

Abstract
Metabolic shifts are a hallmark of numerous biological processes, including the differentiation of stem cells along a specific lineage and the activation of diverse cell types, such as immune cells. This review examines the intricate energy metabolic alterations that occur in diverse biological settings, from embryonic development to adult tissue homoeostasis and disease states. In particular, we emphasise the regulatory function of RNA-binding proteins (RBPs) in coordinating these metabolic shifts and examine how they modulate key pathways, such as glycolysis and oxidative phosphorylation, to meet the dynamic cellular energy demands. This review highlights the various mechanisms by which RBPs regulate these changes, ranging from active involvement in the post-transcriptional regulation of metabolically relevant genes to alteration of an RBP’s function by specific RNAs, metabolites or growth factors. Finally, we consider how ageing and disease affect the function of RBPs and how RBPs can disrupt the delicate balance of metabolic regulation. Taken together, this review provides a comprehensive overview of the critical interplay between RBPs and metabolism and offers insights into potential therapeutic targets for regenerative medicine and age-related diseases.
Psychological profile of patients with Brugada syndrome and the impact of its diagnosis and management
Authors: Santoro Francesco , Di Biase Luigi , Curcio Antonio , Margaglione Alessandra , Tritto Massimo , Baldi Enrico , Ragnatela Ilaria , Anselmino Matteo , Nigro Gerardo , Leccisotti Ivana , Altamura Mario , Bellomo Antonello , Brunetti Natale Daniele , Rapacciuolo Antonio ,   On behalf of the working group on electrophysiology and cardiac pacing of the Italian Society of Cardiology, Di Biase Luigi 
Published: January 2025

Abstract
Brugada syndrome (BrS) is an arrhythmic hereditary disorder affecting mainly males, aged 30–50 years. Type D personality has a prevalence of 32.7% among BrS patients and 15% of these patients have an history of psychiatric disorders. One out of six BrS patients could develop anxiety/depression after BrS diagnosis or after the implantation of a defibrillator. This review evaluates the psychological profile of BrS patients, the impact of its diagnosis, and potential tools to evaluate these features.
Speech-Language Pathologists' Experiences Working With Culturally and Linguistically Diverse Families: A Scoping Review
Authors: Sinclair Rachel L. , Finke Erinn H. , Wu Lin 
Published: January 2025

Introduction:
Evidence-based practices (EBPs) use evidence (external and internal), clinician expertise, and client/caregiver perspectives to deliver effective, individualized care. Each component of EBP is highly relevant and most effective when implemented together. Families with cultural or linguistic backgrounds different from the mainstream experience inequitable treatment across all disciplines. As the United States' population becomes increasingly diverse, it is paramount for speech-language pathologists (SLPs) to obtain education and support to provide evidence-based, culturally responsive care.

Method:
This study conducted a scoping review to determine what is known regarding SLPs' perspectives and experiences working with families or children with different cultural or linguistic backgrounds. Articles were included if they (a) contained empirical novel data, were available in English, were peer-reviewed, and were published; (b) included experiences of SLPs who self-reported that they work with children and/or families with cultural and/or linguistic backgrounds different from themselves or the regional mainstream; and (c) reported effects of cultural or linguistic difference on SLP service provision.

Results:
Results indicated that SLPs encounter many barriers but often exhibit culturally responsive clinical decision making through the consideration of evidence (external and internal) and their clinical expertise and opinion. Multiple strategies for increasing culturally responsive care and areas that would benefit from further research and systemic change were identified.

Discussion:
Barriers and solutions to culturally responsive care represented two areas of needed change: personal and within system. Though not all change may occur immediately, the present study offers suggested solutions for SLPs to implement in their clinical practice for increased culturally responsive care.

Supplemental Material:

https://doi.org/10.23641/asha.28119836
Fine‐grained multi‐path channel estimation and matched reception by single metasurface antenna
Authors: Hao Yinuo , Jin Liang , Xiao Shuaifang 
Published: January 2025

AbstractThis paper investigates methods to enhance antenna's channel information extraction capabilities in wireless communications, particularly in challenging multi‐path environments. Focusing on the issues of channel information loss due to multi‐path superposition at the receiver and multi‐path fading during wireless channel propagation, this paper utilizes metasurface antennas to rapidly reconfigure antenna patterns and construct high‐dimensional projection spaces, thus improving information sensing resolution. Based on this, a channel‐matched receiving pattern design method is proposed to mitigate the communication performance loss caused by multi‐path fading. Furthermore, this paper analyses the comprehensive impact of various metasurface parameters on the performance of the proposed scheme, providing theoretical guidance for engineering implementation. Simulation results demonstrate that the proposed scheme can achieve the performance of multi‐path channel estimation and reception close to those of multi‐antenna arrays using a single radio frequency link.
4.5-Year Follow-up with a Novel Corneal Endothelial Prosthesis
Authors: Lapid-Gortzak Ruth , van der Meulen Ivanka 
Published: January 2025

Abstract
Background Refractory corneal edema is the foremost reason for endothelial corneal transplantation (EK) in the world. Descemet membrane endothelial keratoplasty (DMEK) and Descemet stripping automated endothelial keratoplasty (DSAEK) offer good clinical outcomes. However, human donor tissue is limited in availability and has a complex logistical chain. Many patients in need do not have access to EK. Success of the human donor tissue depends on its quality, the number of rebubbles, repeat keratoplasties, and patient-related risk factors. The use of an endothelial corneal keratoprosthesis could benefit patients with a high risk for graft failure and human graft rejection, and patients in underserved areas where tissue banking is unavailable.
Patients and Methods Case cohort series of 10 eyes of 10 patients implanted with the EndoArt, with a follow-up of up to 4.5 years. Outcome measures are device adherence, central corneal thickness, visual acuity, and incidence of adverse events.
Results In the first seven eyes, the EndoArt was implanted in eyes with low visual potential within the first-in-human (FIH) trial, and in the three remaining eyes, implantation was performed because of either guarded posterior or anterior segment prognosis or the patientʼs wishes. In 9/10 eyes, device adherence was obtained and maintained throughout the follow-up period. Mean corneal thickness decreased from 927 + SD 241 microns to 621 + SD 140 microns. In 6/10 eyes, visual acuity improved from a mean preoperative value of logMAR 1.94 + 0.63 to a mean postoperative value of logMAR 0.8 + 0.64. No pathological thinning or corneal metabolic changes were seen. The surgical technique was developed during the follow-up period.
Conclusion The EndoArt provided a stable decrease in central corneal thickness, improved vision in 60% of eyes, and had no device-related adverse events. The EndoArt is an additional treatment modality for special cases like repeat corneal graft failure in the population of the Western world, or as a primary procedure in underserved areas worldwide.
Implementation of a data-driven quality improvement program in primary care for patients with coronary heart disease: a mixed methods evaluation of acceptability, satisfaction, barriers and enablers
Authors: Hafiz Nashid , Hyun Karice , Tu Qiang , Knight Andrew , Chow Clara K. , Hespe Charlotte , Briffa Tom , Gallagher Robyn , Reid Christopher M. , Hare David L. , Zwar Nicholas , Woodward Mark , Jan Stephen , Atkins Emily R. , Laba Tracey-Lea , Halcomb Elizabeth , Johnson Tracey , Manandi Deborah , Usherwood Tim , Redfern Julie 
Published: January 2025

Background The study aimed to understand the acceptability, satisfaction, uptake, utility and feasibility of a quality improvement (QI) intervention to improve care for coronary heart disease (CHD) patients in Australian primary care practices and identify barriers and enablers, including the impact of COVID-19. Methods Within the QUality improvement for Effectiveness of care for people Living with heart disease (QUEL) study, 26 Australian primary care practices, supported by five Primary Health Networks (PHN) participated in a 1-year QI intervention (November 2019 – November 2020). Data were collected from practices and PHNs staff via surveys and semi-structured interviews. Quantitative and qualitative data were analysed with descriptive statistics and thematic analysis, respectively. Results Feedback was received from 64 participants, including practice team members and PHN staff. Surveys were completed after each of six workshops and at the end of the study. Interviews were conducted with a subgroup of participants (n = 9). Participants reported positive satisfaction with individual QI features such as learning workshops and monthly feedback reports. Overall, the intervention was well-received, with most participants expressing interest in participating in similar programs in the future. COVID-19 and lack of time were identified as common barriers, whereas team collaboration and effective leadership enabled practices’ participation in the QI program. Additionally, 90% of the practices reported COVID-19 effected their participation due to vaccination rollout, telehealth set-up, and continuous operational review shifting their focus from QI. Conclusion Data-driven QI programs in primary care can boost practice staff confidence and foster increased implementation. Barriers and enablers identified can also support other practices in prioritising effective strategies for future implementation.
Facilitators and barriers to adopting a multifaceted chlamydia management intervention in general practice: qualitative findings from Management of Chlamydia Cases in Australia (MoCCA)
Authors: Munari Stephanie C. , Coombe Jacqueline , Bittleston Helen , Temple-Smith Meredith , Fairley Christopher K. , Bateson Deborah , Hellard Margaret , Goller Jane L. , Hocking Jane S. ,   on behalf of the MoCCA Investigators
Published: January 2025

Background Chlamydia is one of the most common sexually transmissible infections globally and can lead to reproductive complications, including pelvic inflammatory disease and infertility. Interventions to reduce disease burden, including retesting for reinfection, partner management, and early detection of complications, are the focus of the Management of Chlamydia Cases in Australia (MoCCA) study, an implementation and feasibility trial aiming to strengthen chlamydia management in Australian general practice. This study aimed to identify factors influencing participation in and adoption of a multifaceted chlamydia management intervention within the general practice setting. Methods We conducted semi-structured interviews with general practice staff (n = 13) from clinics (n = 9) participating in the MoCCA study. Data were analysed using inductive content analysis to identify facilitators and barriers to study participation and intervention adoption. Results Participants felt that practice champions, motivated staff and interventions that improved workflow efficiency, integrated with existing processes and improved patient interactions, facilitated participation in, and adoption of, study interventions. A perceived lack of staff engagement related to time constraints, competing priorities, staff retention issues and interventions that were less convenient to use or had reduced patient uptake were identified as barriers to participation. Conclusions Identifying perceived facilitators and barriers to successful implementation of a multifaceted chlamydia intervention enables public health practitioners to better support general practice in the ongoing uptake and use of evidence-based chlamydia management strategies, ultimately aiming to reduce the burden of chlamydia and its complications in Australia.
An improved method of capture and immobilisation for medium to large-size macropods
Authors: Bedoya-Pérez Miguel A. , Lawes Michael J. , Ottley Brett , Barker Stuart , Tarszisz Esther , McMahon Clive R. 
Published: January 2025

Context Macropods are very susceptible to stress during capture. Capture methods for macropods fall into two categories: trapping and darting. Trapping by nets or a triggered trap mechanism is commonly used for small macropods. Darting is most often used for large macropods that are more prone to stress and capture myopathy when caught in traps. Aim To describe a modified ‘nylon drop-net’ technique for safely capturing medium to large macropods; and post-capture treatments that reduce stress and the potential for myopathy. Methods We used a drop-net to capture 40 agile wallabies (Notamacropus agilis) (24 females and 16 males), ranging in weight from 6 to 24 kg. For immobilisation, a single dose of intramuscular Diazepam (1 mg/kg) and Richtasol, a multivitamin, was administered to reduce the risk of capture myopathy. The longer-term effects of capture on animal condition were monitored in 34 radio-collared individuals for 2 months. Key results No deaths occurred during or as a result of capture or in the 8 weeks following capture. Conclusions Our modified drop-net and handling/treatment regime provides a cost-effective method for capturing medium and small-sized macropod species with very low risk of mortality or morbidity. Implications Our methods improve the welfare and safety of captured medium-sized macropods.
The effect of lexical complexity on grading of Swedish EFL learners’ texts during high-stakes
exams
Authors: Holmberg Sjöling Christian 
Published: January 2025

Abstract
The present study concerns the effect of lexical complexity on grading of Swedish EFL learners’ texts during
high-stakes exams. A learner corpus consisting of 142 texts graded by expert raters and 175 texts graded by teachers was analysed
to establish if the latter graded in agreement with the former as intended by the Swedish National Agency for Education (SNAE).
Four indices of lexical complexity available in TAALED and TAALES were chosen to explore if this is the case. The method includes
conducting ordinal regression with interactions to determine the effect of the independent variables on grade and if these
variables have the same effect in texts graded by teachers and expert raters. The findings reveal a discrepancy between expert
raters and teachers as they appear to consider lexical complexity to a different extent. It was also found that expert raters and
teachers graded more in agreement during source-based writing tasks compared to independent writing tasks.
CIPM key comparison of viscosity CCM.V-K4
Authors: Trujillo S , Arias R , Cękiel I , Gouveia J M , Zhengdong Z , Fujita Y , Wolf H , Rauch J , Trochta D , Wortman R , Neklyudova A , Furtado A , Mekawy M , AlSulaiman F A 
Published: January 2025

Main text
This report describes the fourth CCM key comparison in capillary viscometry among twelve National Metrology Institutes (NMIs), of which, nine NMIs maintain an independent viscosity scale and three NMIs do not maintain an independent viscosity scale. The comparison was carried out between January 8th 2018 and April 30th 2018. Two samples of Newtonian liquids with nominal kinematic viscosities of 170 mm2/s at 20°C, 65 mm2/s at 40°C and 10 mm2/s at 100°C for sample A and 10 000 mm2/s at 10°C 4 600 mm2/s at 20°C and 120 mm2/s at 100°C for sample B. Both samples were prepared by CENAM and provided to each one of the participants NMIs. For each of the samples at three temperatures, a total number of 64 measurements were carried out by the participants. From the values reported for the viscosity measurements, the key comparison reference values (KCRV) for six data sets were calculated. The degrees of equivalence were evaluated by the difference of the reported viscosity value with the KCRV. It was found that 9 measurements (14%) showed a degree of equivalence greater than the estimated uncertainty for the degree of equivalence.
To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database https://www.bipm.org/kcdb/.
The final report has been peer-reviewed and approved for publication by the CCM, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).
Quantum dot distributed feedback laser grown on silicon with laterally coupled gratings
Authors: Yang Bo , Han Dong , Wei Wenqi , Cui Xiangru , Wang Zihao , Wang Ting , Zhang Jianjun 
Published: January 2025

Abstract
The direct epitaxy of quantum dot (QD) lasers on silicon was considered as holy grail of integrated silicon photonics. With demonstration of various InAs/GaAs QD lasers directly grown on silicon substrates, there are limited research carried on single longitudinal mode lasers on silicon. Here, to avoid any regrowth procedures, distributed feedback (DFB) QD lasers on silicon are fabricated with lateral coupled (LC) gratings via simplified fabrication process. The LC-DFB laser has a maximum laser power of 4.5 mW and threshold current of 80 mA under continuous-wave current mode at room temperature. Under injection current of 110 mA, the side mode suppression ratio (SMSR) reaches 50 dB at room temperature. The RIN of the laser is measured with value of -135dB/Hz with corresponding optical linewidth of 3.5 MHz.
Design of NI HTS solenoid for PSI positron production experiment
Authors: Kosse Jaap , Garcia Rodrigues Henrique , Michlmayr Thomas , Duda Michal , Müller Stephan , Brem André , Sotnikov Dmitry , Sanfilippo Stéphane , Auchmann Bernhard 
Published: January 2025

Abstract
This paper presents the design of a non-insulated (NI) high-temperature superconductor (HTS) 15 T solenoid with a 72 mm warm bore, intended for use in the PSI Positron Production (P^3) experiment. The P^3 experiment, scheduled to start in Q3 2026, aims to demonstrate a high-yield positron source that is relevant in the context of FCC-ee. &#xD;&#xD;The coils will be solder-impregnated using techniques developed with a small-bore HTS NI coil stack. This magnet produced a magnetic field of 18 T at 12 K and 2 kA, in a cryogen-free, conduction-cooled setup. Similarly, the P^3 magnet will be conduction-cooled by two cryocoolers. This larger-bore magnet is designed to operate at 15 K with a nominal operating current of 1.2 kA. &#xD;&#xD;To ensure the protection of the NI magnet, quench prevention is the preferred strategy. Several potential failure modes are analyzed, including thermal runaway in the event of failures in the current leads, power supply, or cryocoolers. By enhancing the cold mass' heat capacity through the addition of a large lead mass, the stored magnetic energy can be safely dissipated in the cold mass through the electrical path formed by the superconductor and the solder.&#xD;&#xD;Mechanical analysis indicates that the hoop, radial and axial stresses are kept below allowable limits.
MECHANICAL AND MICROSTRUCTURAL BEHAVIOR OF ZE41 MAGNESIUM ALLOY REINFORCED WITH INCONEL FOR HIGH-PERFORMANCE APPLICATIONS
Authors: R Radhakrishnan , M S STARVIN , R Pandiyarajan 
Published: January 2025

Abstract
Magnesium alloys are known for their lightweight and desirable properties, as they hold significant potential for innovative engineering applications. The present study investigated the mechanical and microstructural characteristics of a magnesium alloy (ZE41) reinforced with Inconel ceramic particulates. The Magnesium Metal Matrix Composites (MMMC) were fabricated using the stir casting method, with varying weight percentages (wt. %) of Inconel (0, 2, 4, 6, 8, 10, 12 wt. %). The microstructural examinations of the MMMC specimens were performed using SEM, SEM+EDS analyses, and Optical Microscopy (OM), which revealed a strong interfacial bond well-defined between the Magnesium matrix and the Inconel particulates. This uniform distribution of reinforcement particulates significantly enhanced the mechanical properties of the composite materials. The tensile tests showed that the Ultimate Tensile Strength (UTS) improved progressively with up to 8% Inconel reinforcement, achieving a maximum UTS of 202.56 MPa, a 24.47% improvement compared to the base Magnesium alloy. However, the UTS decreased beyond 8% Inconel due to increased brittleness. Hardness tests indicated that the highest hardness value of 76.1 HV was achieved for the composite containing 12 wt.% Inconel, marking an 18.85% increase over the base alloy. Additionally, the wear rate decreased with increasing Inconel reinforcement, demonstrating improved wear resistance. Specifically, the wear rate dropped from 2.58 × 10-7 g/mm at 0% Inconel to 0.84 × 10-7 g/mm at 12% Inconel, showing a 67.44% reduction in wear rate compared to the pure AA6082 matrix. The findings from the present work, indicate the potential of Inconel-reinforced ZE41 composites towards achieving optimized strength and hardness levels for applications requiring high-performance materials. The present research is a contribution to the body of knowledge on the development of magnesium composites and highlights the importance of reinforcement compositions for enhancing their mechanical and microstructural characteristics.