bluuebunny/crossref_metadata_2025_split huggingface dataset:
Targeting histone acetylation to overcome drug resistance in the parasiteTrichomonas vaginalis
Authors: Seifert-Gorzycki Julieta , Muñoz Daniela , Lizarraga Ayelen , Iriarte Lucrecia , Coceres Verónica , Strobl-Mazzulla Pablo H. , de Miguel Natalia 
Published: January 2025

ABSTRACTTrichomoniasis, caused by the parasiteTrichomonas vaginalis, is the most common non-viral sexually transmitted infection. Current treatment relies exclusively on 5-nitroimidazole drugs, with metronidazole (MTZ) as the primary option. However, the increasing prevalence of MTZ-resistant strains poses a significant challenge, particularly in the current absence of alternative therapies. Several studies have revealed that the development of metronidazole resistance inT. vaginalisis linked to genomic and transcriptional alterations. Given the role of epigenetic regulation in controlling gene expression, we investigated whether targeting histone deacetylase (HDAC) enzymes could influence drug resistance. Treatment of an MTZ-resistant strain (B7268) with the HDAC inhibitor, trichostatin A (TSA), in combination with MTZ enhanced drug sensitivity and induced significant genome-wide transcriptional changes, as revealed by RNA-seq analysis. To identify drug-related genes epigenetically silenced in the resistant strain but highly active in a sensitive strain, we compared the expression levels of the genes affected by TSA and MTZ treatment with their baseline expression profiles in both resistant and sensitive strains. This analysis identified 130 candidate genes differentially expressed in the sensitive strain NYH209, less expressed in the resistant B7268 strain, that exhibited significant expression changes upon TSA and MTZ treatment. Functional validation involved transfecting the B7268 strain with plasmids encoding four individual candidate genes: a thioredoxin reductase (TrxR), a cysteine synthase (CS), and two genes containing Myb domains (Myb5 and Myb6). Overexpression of three of these genes resulted in a marked reduction in MTZ resistance, demonstrating their role in modulating drug sensitivity. Our findings identified three novel genes that modulate drug resistance inT. vaginalis. This study reveals a previously unknown epigenetic mechanism underlying drug resistance and highlights the therapeutic potential of targeting epigenetic factors, such as HDACs, to overcome resistance and improve treatment efficacy.
Modeling the acutely injured brain environmentin vitro
Authors: María Arzate Dulce , Álvaro Víctor , Prádanos-Senén Ana Victoria , Gallego Lucía , Manzano Diana , Llorente-Sáez Celia , Bartolomé Rocío , Ferrarini Alessia , López Juan Antonio , Murenu Elisa , Berninger Benedikt , Ortega Felipe , Götz Magdalena , Heinrich Christophe , Gascón Sergio 
Published: January 2025

ABSTRACTA major challenge to study the regenerative potential of the injured brain is the limited access to this organin vivo. To address this, we developed an innovative gliosis model that, although establishedin vitro, originates from a genuine injuryin vivo. The model relies on reactive glia acquiring enhanced adhesion, facilitating their rapid adaptation toin vitroconditions, where it faithfully recapitulates key features of brain injury. These include a secretome associated with injury pathways, degenerative responses like neuronal death and neuroinflammation, and regenerative processes such as progenitor proliferation, recruitment and commitment to oligodendrocytes. Moreover, the exposure of adult glial cells to this culture medium recapitulates their acquisition of multipotency observed in both mouse and human injured brains. Finally, our approach allows studying glia-to-neuron reprogramming, a process challenging to tacklein vivo. Consequently, we present a novel tool for exploring stem cell dynamics and regenerative behaviors in CNS pathology.
Baryon number transportation over full rapidity space in
pp
collisions at energies available at the CERN Large Hadron Collider
Authors: Barman Banajit , Hussain Nur , Bhattacharjee Buddhadeb 
Published: January 2025

The estimation of the antibaryon to baryon ratio is considered to be a useful tool for studying baryon number transport in pp, pA, and AA collisions. For this paper, the event generator with various tunes is used to measure the Λ¯/Λ ratio as a function of rapidity (y), transverse momentum (pT ), and multiplicity within both ALICE and LHCb acceptances. The results obtained using various Monte Carlo data for pp collisions at s=0.9 and 7 TeV are compared with the experimentally measured values of Λ¯/Λ ratio of ALICE and LHCb experiments. Out of the various studied tunes of 8.3, the string junction model is found to be the most successful to describe the experimentally observed results. Evidence of a considerable amount of baryon number transportation from the beam fragmentation to the ALICE and LHCb acceptances could be recognized.

Published by the American Physical Society
2025
Minding the gap: Testing natural anomaly-mediated SUSY breaking at high luminosity LHC
Authors: Baer Howard , Barger Vernon , Bolich Jessica , Dutta Juhi , Sengupta Dibyashree 
Published: January 2025

While the minimal anomaly-mediated SUSY breaking model (mAMSB) seems ruled out by constraints on Higgs mass, naturalness and wino dark matter, a slightly generalized version dubbed natural AMSB (nAMSB) remains both viable and compelling. Like mAMSB, nAMSB features winos as the lightest gauginos, but unlike mAMSB, nAMSB allows a small μ parameter so that Higgsinos are the lightest of electroweakinos (EWinos). nAMSB spectra depend on the input value of gravitino mass m3/2, where the lower range of m3/2 is excluded by LHC gluino pair searches while a higher m3/2 band is excluded by LHC limits on wino pair production followed by boosted hadronic wino decays. A remaining intermediate gap in m3/2 values remains allowed by present LHC searches, but appears to be completely explorable by high luminosity upgrades of LHC (HL-LHC). We explore a variety of compelling discovery channels that may allow one to close the intermediate gap in m3/2 values: (1) same-sign diboson+ET (SSdB) production arising from wino pair production, leading to same-sign dileptons plus missing ET, (2) trilepton production arising from wino pair production and (3) soft dilepton plus jet events from Higgsino pair production, (4) top-squark pair production. From our signal-to-background analysis along a nAMSB model line, we expect HL-LHC to either discover or rule out the nAMSB model with 3000  fb−1 of integrated luminosity.

Published by the American Physical Society
2025
Secondary lepton production, propagation, and interactions
Authors: Cummings Austin , Krebs Ryan , Wissel Stephanie , Alvarez-Muñiz Jaime , Carvalho Washington R. , Romero-Wolf Andrés , Schoorlemmer Harm , Zas Enrique 
Published: January 2025

Charged current interactions of neutrinos inside the Earth can result in secondary muons and τ-leptons which are detectable by several existing and planned neutrino experiments through a wide variety of event topologies. Consideration of such events can improve detector performance and provide unique signatures which help with event reconstruction. In this work, we describe , a propagation tool for neutrinos and charged leptons that builds on the fast framework. considers energy losses of charged leptons, modeled both continuously for performance or stochastically for accuracy, as well as interaction models for all flavors of neutrinos, including the Glashow resonance. We demonstrate the results from including these effects on the Earth emergence probability of various charged leptons from different flavors of primary neutrino and their corresponding energy distributions. We find that the emergence probability of muons can be higher than that of taus for energies below 100 PeV, whether from a primary muon or τ neutrino, and that the Glashow resonance contributes to a surplus of emerging leptons near the resonant energy.

Published by the American Physical Society
2025
Co-opted boards and bidder performance
Authors: Shams Syed , Luong Hoa , Ovi Nafisa Zabeen 
Published: January 2025

PurposeDefining co-opted directors as those who join a company’s board after an incumbent chief executive officer assumes office, this study aims to investigate the influence of co-opted boards on bidder performance.Design/methodology/approachThis study applies ordinary least squares regression analyses to a sample of 8,939 acquisition observations announced by US firms spanning the 1999–2019 period. Event study methodology was employed to capture the market response to acquisition announcements. Propensity score matching technique, a two-stage least squares instrumental variable approach and model selection through the Lasso method were performed for robustness and endogeneity correction purposes.FindingsThe results depict a significant negative relationship between a co-opted board and return to acquirers, suggesting that managers under co-opted boards make value-destructing Mergers and Acquisitions deals. We also show that the relationship between board co-option and acquisition performance is positively moderated by institutional ownership while being negatively moderated by an entrenched board. Our additional tests reveal that board co-option reduces acquisition efficiency and leads to worse financial performance.Practical implicationsThis study offers important implications for regulators and policymakers by highlighting how poor monitoring of the board of directors can influence announcement returns.Originality/valueTo the best of the authors’ knowledge, this paper appears to be the first investigation that makes a link between board co-option and various dimensions of acquisition decision.
A bibliometric analysis of financial fraud exploiting the elderly in the digital age
Authors: Lindez-Macarro María-Elena , Gallego-Losada Rocio , Montero-Navarro Antonio , Rodríguez-Sánchez José-Luis 
Published: January 2025

PurposeThe purpose of this review is to conduct a bibliometric analysis of financial fraud exploiting the elderly by mapping its evolution, identifying major metrics and discussing directions for future research.Design/methodology/approachA bibliometric analysis was conducted, based on 434 articles retrieved from the Web of Science that represent the academic literature on the topic from 1995 to the first quarter of 2024. This paper analyses the antecedents of financial fraud exploiting the elderly, the publication trends and the most prolific countries, institutions, journals, research areas and authors. Bibliometric analyses based on co-citation and co-words explore the intellectual structure of the topic. A bibliographic coupling analysis reveals the hottest research trends in this field.FindingsA significant increase in the number of publications in recent years shows the importance gained by this research stream. The bibliometric analysis identifies four clusters throughout the literature: differentiation of types of elder abuse; protection of the elderly from fraud; cognitive and decision-making capacity in ageing; and factors influencing fraud victimization of the eldest. The most recent research lines identified through bibliographic coupling focused on the contextual and personal antecedents of financial exploitation of the elderly, as well as the possible impact of interventions. Several key research gaps and additional suggestions for further studies, as well as action lines for the financial authorities and economic agents, are outlined.Originality/valueThis paper contributes to knowledge about financial fraud exploiting the elderly synthesizing the existing literature, stressing that the banking industry has to deal with such financial fraud in the context of a growing relevance of the silver economy.
Transformation of national ranking score for positioning higher education institutions in international ranking – a case on India
Authors: Gupta Seema , Sushil S. , Gulati Khushboo 
Published: January 2025

PurposeThe study intends to evaluate first the performance of Indian institutions ranked in the National Institutional Ranking Framework 2019. Second, it compares the performance of Indian institutions with international rankings. Third, it spotlights a model for predicting the criteria that will improve these institutions' national and international rankings.Design/methodology/approachThe cluster analysis has been undertaken to group the sample of 100 institutions into three groups. Further, discriminant analysis has been performed to uncover the criteria that cause significant variations in the ranking. Third, a comparative study is conducted on the international ranking parameters to explore the factors responsible for their lower rank in the global ranking.FindingsThe results reveal that most institutions are low-performing for “research and professional practice” and “peer perception” criteria. Meanwhile, the performance of top-ranked institutions is unsatisfactory on the “outreach and inclusivity” criterion. The study also finds that the national ranking of Indian institutions is significantly affected by the “research and professional practice” and “peer perception” scores, which also results in their low rank in the Times Higher Education (THE) ranking.Research limitations/implicationsThis study can be an exemplary model for any developing nation to upgrade its higher education institutions' (HEIs’) performance in international tablesPractical implicationsThe government can develop policies to better low-performing universities and initiate policy changes in the incapacitated spheres for building a globally distinctive image for the Indian universities. The policymakers can recognise the institutions showcasing excellent research and teaching performance and encourage them accordingly to be the best research or teaching universities as it is not possible for every university to be the best in teaching and research aspect both.Social implicationsThe policymakers can also focus more on developing research collaboration form other countries and industry for research universities and professional staff from leading industries for teaching collaborations for the rest. The HPIs should focus on creating a global image for themselves and MPIs and LPIs should be encouraged to raise their national ranking.Originality/valueThe study is a novel attempt to present the present state of Indian institutions grounded on all the national ranking criteria. It further compares the performance of sample NIRF institutions with international rankings criterion to suggest policy changes for improving their performance at the global level.
Research on the tribological properties of kaolin/MoDDP composite lubricant additives under heavy load and impact conditions
Authors: Wang Lei , Wang Xinming , Li Liang , Yang Chuang , Zhu Yuqin 
Published: January 2025

Purpose
With respect to severe working conditions such as heavy load and impact, this paper aims to investigate the friction reduction and anti-wear performance of kaolin and molybdenum dialkyl dithiophosphate (MoDDP) composite lubricant additives to improve the lubrication effect of a single additive.

Design/methodology/approach
A four-ball friction test was carried out to determine the optimal concentration of kaolin and organic molybdenum additives and the tribological properties of the kaolin/MoDDP composite lubricant additives. A ring block test of composite lubricant additives was designed to investigate its lubrication performance under the severe working conditions of low speed, heavy load and impact.

Findings
The results showed that the optimal addition mass fractions of kaolin and MoDDP were 4.0 and 1.5 Wt.%, respectively, when kaolin and MoDDP were used as single lubricant additives. Compared with the single additive, the 4.0 Wt.% kaolin/1.5 Wt.% MoDDP composite lubricant additive showed excellent friction reduction and anti-wear effects under heavy load and impact conditions. Physicochemical analysis of the wear surface revealed that the lamellar kaolin additive and MoDDP had excellent synergistic effects, and the friction process promoted the generation of lubricant films containing a chemically reactive layer of MoS2, MoO2, FeS2 and Fe2O3 and a physically adsorbent layer containing SiO2 and Al2O3, which play important roles in anti-wear and friction reduction.

Originality/value
The excellent friction reduction and anti-wear effects of lamellar silicate minerals and the excellent antioxidant properties and good synergistic effects of molybdenum were comprehensively used to develop the composite additives with great lubricating properties.
Integrating intangible cultural heritage elements into mobile games: an exploration of player cultural identity
Authors: Jiang Qianling , Qian Jue , Zang Yong 
Published: January 2025

PurposeIn today’s world, there’s a growing recognition of the importance of cultural heritage. Mobile games have emerged as a powerful medium for the dissemination of culture. However, there’s a noticeable gap in the existing research concerning the cultural experiences within games and how they contribute to the development of cultural identity. This study addresses this gap by developing a scale to evaluate cultural experiences and constructing a theoretical model of cultural identity. By focusing on the popular mobile game “王者荣耀” (King of Glory), we highlight its rich representation of intangible cultural heritage elements and its influence on players' cultural identity. By doing so, it seeks to provide valuable insights and guidance for the development and design of mobile games.Design/methodology/approachTo achieve its objectives, this study employs a combination of user interviews, factor analysis and structural equation modeling. These methods are used to identify four key dimensions of cultural experience and explore the intricate relationships between various influencing factors and the formation of cultural identity.FindingsThe concept of cultural experience within games encompasses four distinct facets: emotional connection, design aesthetics, perceived playfulness and knowledge acquisition. Aesthetic appreciation notably influences emotional connection and the overall enjoyment of the game. Furthermore, emotional connection plays a pivotal role in facilitating users' acquisition of knowledge. Additionally, users' cultural heritage values positively impact emotional connection, aesthetic appreciation, emotional attachment and, ultimately, their cultural identity. Within game-based cultural experiences, emotional connection and knowledge acquisition emerge as central elements that significantly influence users' sense of cultural identity.Originality/valueThe originality of this study lies in its pioneering construction of a comprehensive framework for assessing the impact of cultural experiences within mobile games on cultural identity. By examining “王者荣耀,” this study bridges the gap between intangible cultural heritage and interactive digital media, making an original and significant contribution to both fields.
Skip the AI-BOTs: let’s have real conversations in human-centric services
Authors: Dastane Omkar , Ooi Mun-Yee , Aw Eugene Cheng-Xi , Shyu Wen-Hwa , Tan Garry Wei-Han 
Published: January 2025

Purpose
This study integrates the theories of perceived value and human-robot interaction to develop a framework for examining the influence of artificial intelligence-based service chatbot’s (AI-BOT) attributes on user stickiness (US) in the context of human-centric services. The study specifically examines the mediating role of perceived competence (PC) in the association between AI-BOT attributes and the US. It also examines how perceived empathy (PE) moderates the correlation between PC and US.

Design/methodology/approach
The empirical data was collected through a self-administered questionnaire from 470 respondents with prior experience of interacting with AI-BOTs. The data was analysed using SMART-PLS by performing structural equation modelling.

Findings
The study found a positive and significant impact of selected AI-BOT attributes on US. Among all selected attributes, personalization had the strongest impact on PC and recommendations had the strongest impact on US. Responsiveness did not emerge as a contributory factor for generating PC. This paper confirmed the mediating role of PC among relationships between selected attributes and US but such mediation was minor. PE moderated the relationship between PC and US negatively.

Originality/value
This study provides novel insights by identifying that PE dampens the relationship between PC and US. Additionally, it provides a framework to stimulate the US for AI-BOTs by combining technical aspects (human-computer interaction theory) with value aspects (theory of perceived value) and by positioning constructs specific to human-centric services. All in all, the study offers a dual-layered perspective regarding value-in-use resulting in a comprehensive understanding of human-technology interactions during human-centric service encounters.
Testing a consumer-based brand equity model for wine tourism destinations
Authors: Tasci Asli D.A. , Back Robin M. 
Published: January 2025

PurposeConsumer-based brand equity (CBBE) has been used in tourism and hospitality to measure the success of firm-level as well as destination-level brands. As wine tourism gained attention during the past two decades, researchers endeavored to use CBBE to understand consumer reactions to different wine tourism destinations. However, research in this domain has been divergent, with many models of CBBE with diverse components, without being validated for different destinations.Design/methodology/approachThe current study tested the validity of a CBBE model with the six most-widely used components, namely brand familiarity, brand image, perceived quality, consumer value, brand value and brand loyalty. The model was first tested for five domestic wine tourism destinations in the United States (n = 247) and retested for five global wine tourism destinations (n = 248). Partial least squares structural equation modeling (PLS-SEM) of data from 495 respondents was used for analysis.FindingsFindings indicated that a four-component CBBE model with brand familiarity, brand image, consumer value and brand loyalty may be a more parsimonious model in the wine tourism destination context.Practical implicationsKnowledge of the CBBE of the destination within which the winery is located will enable the winery to understand the extent to which it can rely on this CBBE for the sale of their wines versus the extent to which they must rely on their own marketing activities to develop CBBE in their specific wine brand(s).Originality/valueThe study is unique in using multiple wine tourism destinations to test a CBBE model.