bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development and validation of a risk prediction model for medication administration errors among neonates in the neonatal intensive care unit: a study protocol
Authors: Henry Basil Josephine , Premakumar Chandini Menon , Mhd Ali Adliah , Mohd Tahir Nurul Ain , Seman Zamtira , Mohamed Shah Noraida 
Published: February 2023

IntroductionMedication administration errors (MAEs) are the most common type of medication error. Furthermore, they are more common among neonates as compared with adults. MAEs can result in severe patient harm, subsequently causing a significant economic burden to the healthcare system. Targeting and prioritising neonates at high risk of MAEs is crucial in reducing MAEs. To the best of our knowledge, there is no predictive risk score available for the identification of neonates at risk of MAEs. Therefore, this study aims to develop and validate a risk prediction model to identify neonates at risk of MAEs.Methods and analysisThis is a prospective direct observational study that will be conducted in five neonatal intensive care units. A minimum sample size of 820 drug preparations and administrations will be observed. Data including patient characteristics, drug preparation-related and administration-related information and other procedures will be recorded. After each round of observation, the observers will compare his/her observations with the prescriber’s medication order, hospital policies and manufacturer’s recommendations to determine whether MAE has occurred. To ensure reliability, the error identification will be independently performed by two clinical pharmacists after the completion of data collection for all study sites. Any disagreements will be discussed with the research team for consensus. To reduce overfitting and improve the quality of risk predictions, we have prespecified a priori the analytical plan, that is, prespecifying the candidate predictor variables, handling missing data and validation of the developed model. The model’s performance will also be assessed. Finally, various modes of presentation formats such as a simplified scoring tool or web-based electronic risk calculators will be considered.
Detrital zircon geochronology and provenance of the Mesoproterozoic Husky Creek Formation: a fluvial sandstone recording the waning stages of one of Earth's largest magmatic episodes
Authors: Meek Robert D. , Ielpi Alessandro , Rainbird Robert H. , Davis William J. 
Published: February 2023

The Mesoproterozoic Husky Creek Formation is an interlayered redbed and basalt package that overlies a ca. 2.5 km thick, regionally extensive basaltic plateau linked to the 1.27 Ga Mackenzie Large Igneous Province. This succession provides an opportunity to study the interaction between contemporaneous fluvial sedimentation and flood basalt volcanism. The Husky Creek Formation is approximately 1900 m thick, consisting predominantly of fluvial channel and subordinate floodplain and eolian strata dominated by lithic detritus intercalated with basalt flows. U–Pb dating of detrital zircon grains collected from four stratigraphic levels in the Husky Creek Formation reveals two main age groupings: (1) a 1270 Ma peak attributed to the Mackenzie Large Igneous Province; and (2) Pre-1.6 Ga detrital zircon ages, which reflect sources from a broad region of northwestern Laurentia and are interpreted to be recycled from underlying sedimentary rocks of the Hornby Bay Basin. An upsection decrease in the proportion of ca. 1270 Ma zircon grains, coupled with increasing sandstone compositional maturity, reflects the expansion of the drainage basin during burial of a volcanic pile, with recycling becoming more dominant as the Husky Creek Formation accumulated. The Husky Creek Formation was deposited in the waning stages of the Mackenzie Igneous Event by west-flowing rivers into a geographically restricted basin above an extensive mafic volcanic plateau. This paper provides insight into fluvial basin development during the aftermath of one of Earth's largest igneous events.
Eco-friendly management of rice stem borer in spring rice (chaite-5)
Authors: Kakshapati Pranita , Shrestha Raksha , Khatiwada Sumira 
Published: February 2023

Since chemical pesticides have a variety of short- and long-term social, economic, and environmental repercussions, research was conducted in Baniyani, Jhapa, Nepal from January to July 2021 to manage the Yellow Stem Borer (YSB) of rice in an environmentally responsible manner. The research followed the Randomized Complete Block Design (RCBD) with three replications and seven treatments using the spring rice variety Chaite-2. The seven treatments used were spinosad 45% SC, Bacillus Thuringensis var krustaki + saccharopolyspora spinosad 15% SC, Azadiractin 0.3%, Chinaberry (Bakaino) leaf extract, Mugwort (Titepati) leaf extract, Metarhizium anisopliae and untreated plot. In order to evaluate the efficacy of the treatments, the number of dead heart and white head symptoms were counted at various time intervals, namely 7, 15, and 21 days after spraying (DAS). At the vegetative and reproductive stages of rice, the rice stem borer causes the symptoms known as "dead heart" and "white head," respectively. The eco-friendly insecticides significantly altered how the rice stem borer was affected. Among the insecticides, Spinosad 45%SC caused the highest reduction in dead hearts and whiteheads. Spinosad 45% SC treated plot showed highest yield (7.5tha-1). Given its effectiveness and eco-friendliness, spinosad could be regarded as the most successful eco-friendly insecticide for controlling the rice pest known as the Rice Stem Borer.
Combination Sodium Nitrite and Hydralazine Therapy Attenuates Heart Failure With Preserved Ejection Fraction Severity in a “2‐Hit” Murine Model
Authors: LaPenna Kyle B. , Li Zhen , Doiron Jake E. , Sharp Thomas E. , Xia Huijing , Moles Karl , Koul Kashyap , Wang John S. , Polhemus David J. , Goodchild Traci T. , Patel Ravi B. , Shah Sanjiv J. , Lefer David J. 
Published: February 2023

Background
Recent studies have suggested that cardiac nitrosative stress mediated by pathological overproduction of nitric oxide (NO) via inducible NO synthase (iNOS) contributes to the pathogenesis of heart failure with preserved ejection fraction (HFpEF). Other studies have suggested that endothelial NO synthase (eNOS) dysfunction and attenuated NO bioavailability contribute to HFpEF morbidity and mortality. We sought to further investigate dysregulated NO signaling and to examine the effects of a NO‐based dual therapy (sodium nitrite+hydralazine) following the onset of HFpEF using a “2‐hit” murine model.

Methods and Results
Nine‐week‐old male C57BL/6 N mice (n=15 per group) were treated concurrently with high‐fat diet and N(ω)‐nitro‐L‐arginine methyl ester (L‐NAME) (0.5 g/L per day) via drinking water for 10 weeks. At week 5, mice were randomized into either vehicle (normal saline) or combination treatment with sodium nitrite (75 mg/L in the drinking water) and hydralazine (2.0 mg/kg IP, BID). Cardiac structure and function were monitored with echocardiography and invasive hemodynamic measurements. Cardiac mitochondrial respiration, aortic vascular function, and exercise performance were also evaluated. Circulating and myocardial nitrite were measured to determine the bioavailability of NO. Circulating markers of oxidative or nitrosative stress as well as systemic inflammation were also determined. Severe HFpEF was evident by significantly elevated E/E', LVEDP, and Tau in mice treated with L‐NAME and HFD, which was associated with impaired NO bioavailability, mitochondrial respiration, aortic vascular function, and exercise capacity. Treatment with sodium nitrite and hydralazine restored NO bioavailability, reduced oxidative and nitrosative stress, preserved endothelial function and mitochondrial respiration, limited the fibrotic response, and improved exercise capacity, ultimately attenuating the severity of “two‐hit” HFpEF.

Conclusions
Our data demonstrate that nitrite, a well‐established biomarker of NO bioavailability and a physiological source of NO, is significantly reduced in the heart and circulation in the “2‐hit” mouse HFpEF model. Furthermore, sodium nitrite+hydralazine combined therapy significantly attenuated the severity of HFpEF in the “2‐hit” cardiometabolic HFpEF. These data suggest that supplementing NO‐based therapeutics with a potent antioxidant and vasodilator agent may result in synergistic benefits for the treatment of HFpEF.
Improving Precipitation Forecasts with Convolutional Neural Networks
Authors: Badrinath Anirudhan , Delle Monache Luca , Hayatbini Negin , Chapman Will , Cannon Forest , Ralph Marty 
Published: February 2023

Abstract
A machine learning method based on spatial convolution to capture complex spatial precipitation patterns is proposed to identify and reduce biases affecting predictions of a dynamical model. The method is based on a combination of a classification and dual regression model approach using modified U-Net convolutional neural networks (CNN) to post-process daily accumulated precipitation over the US west coast. In this study, we leverage 34 years of high resolution deterministic Western Weather Research and Forecasting (West-WRF) precipitation reforecasts as training data for the U-Net CNN. The data is split such that the test set contains 4 water years of data that encompass characteristic west coast precipitation regimes: El Niño, La Niña, and dry and wet El Niño/Southern Oscillation (ENSO-neutral) water years. On the unseen 4-year data set, the trained CNN yields a 12.9-15.9% reduction in root mean square error (RMSE) and 2.7-3.4% improvement in Pearson correlation (PC) over West-WRF for lead times of 1-4 days. Compared to an adapted model output statistics correction, the CNN reduces RMSE by 7.4-8.9% and improves PC by 3.3-4.2% across all events. Effectively, the CNN adds more than a day of predictive skill when compared to West-WRF. The CNN outperforms the other methods also for the prediction of extreme events, which we define as the top 10% of events with the greatest average daily accumulated precipitation. The improvement over West-WRF’s RMSE/PC for these events is 19.8-21.0%/4.9-5.5% and MOS’s RMSE/PC is 8.8-9.7%/4.2-4.7%. Hence, the proposed U-Net CNN shows significantly improved forecast skill over existing methods, highlighting a promising path forward for improving precipitation forecasts.
Potassium citrate-derived porous carbon with high CO2 capture and Congo red adsorption performance
Authors: Wang Song , Zhang Tingting , Li Jiaxin , Hua Yumeng , Dou Jiali , Chen Xuecheng , Li Sanxi 
Published: February 2023

AbstractThe objective is to achieve the goal of carbon neutrality, controlling CO2 emissions is a primary problem to be solved in the current environmental protection field. Eliminating the environmental pollution of dyes in industrial wastewater is also an urgent problem to be solved in the field of environmental protection. The adsorption technique is an effective way to deal with these two issues. Developing high-efficiency adsorbents is an essential work in the adsorption field. In this work, a simple carbonization method has been developed to prepare porous carbon. The morphology and structure of the prepared porous carbon were investigated by scanning electron microscopy, X-ray photoelectron spectroscopy, X-ray diffraction, and surface area measurement. By studying the influence of preparation conditions on the structure and properties of the prepared carbon materials, it was found that the carbon materials prepared at 900 ℃ (PCMCA-900) exhibited a high specific surface area of 1476 m2 g−1 and a high total pore volume of 0.951 cm3 g−1. The PCMCA-900 showed the highest CO2 uptake of 7.67 mmol g−1 at 0 ºC and the adsorption capacity of PCMCA-900 decreased by less than 5% after 10 times recycling. Moreover, when PCMCA-900 was used as an adsorbent to remove Congo red in water, an adsorption capacity of 652.3 mg g−1 was achieved. Therefore, potassium citrate-derived porous carbon is a desirable candidate for excellent CO2 adsorption and Congo red in industrial wastewater.
Non-adherence to cervical cancer screening recommendations among women in Eswatini: a cross-sectional study
Authors: Khumalo Phinda G. , Carey Mariko , Mackenzie Lisa , Sanson-Fisher Rob 
Published: February 2023

AbstractBackgroundIn 2018, Eswatini had the world's highest age-standardised cervical cancer incidence rate. Cervical cancer screening reduces women’s risk of invasive cervical cancer. Data on adherence to cervical cancer screening recommendations in Eswatini are scarce. The purpose of the current study was to determine Eswatini women’s self-reported adherence to cervical cancer screening recommendations, attitudes toward screening, and factors associated with non-adherence.MethodsA cross-sectional survey of women (n = 377) aged 25 to 59 accessing primary healthcare clinics (n = 4) in Eswatini assessed screening participation, attitudes and knowledge regarding cervical cancer screening, and socio-demographic variables. Adjusted logistic regression was used to assess factors associated with non-adherence to Eswatini cervical cancer screening recommendations.ResultsOne hundred and sixty-six (44%) women were classified as adherent to cervical cancer screening recommendations. Attitudinal barriers endorsed by over one-third of participants included a perceived low risk of cervical cancer (n = 161, 43%) and a view that screening is likely to be painful (n = 146, 38%). Participants had higher odds of being classified as non-adherent if they: were single compared with married (OR = 1.78, 95% CI: 1.05, 3.01,p = 0.03), perceived screening as likely painful (OR = 4.43, 95% CI: 2.62, 7.46,p < 0.001); and had not been advised by a doctor/ nurse to screen (OR = 2.82, 95% CI: 1.71, 4.64,p < 0.001). Also, a 1-year increase in age was associated with an increase in the odds of being classified as non-adherent (OR = 1.42, 95% CI: 1.39, 1.45,p = 0.01).ConclusionsSelf-reported adherence was moderate among this group of women. Tailored interventions are needed to increase participation in cervical cancer screening, especially for those women with characteristics associated with being classified as non-adherent. Primary healthcare clinic nurses (and other health providers) may contribute toward improving participation in cervical cancer screening by advising eligible women to screen and providing health education addressing negative attitudes toward screening.
Mastering targeted genome engineering of GC-rich oleaginous yeast for tailored plant oil alternatives for the food and chemical sector
Authors: Shaigani Pariya , Fuchs Tobias , Graban Petra , Prem Sophia , Haack Martina , Masri Mahmoud , Mehlmer Norbert , Brueck Thomas 
Published: February 2023

Abstract
Background
Sustainable production of triglycerides for various applications is a major focus of microbial factories. Oleaginous yeast species have been targeted for commercial production of microbial oils. Among all the oleaginous yeasts examined in a previous comparative study, Cutaneotrichosporon oleaginosus showed the highest lipid productivity. Moreover, a new lipid production process for C. oleaginosus with minimal waste generation and energy consumption resulted in the highest lipid productivity in the history of oleaginous yeasts. However, productivity and product diversity are restricted because of the genetic intractability of this yeast. To date, successful targeted genetic engineering of C. oleaginosus has not yet been reported.

Results
The targeted gene editing was successfully carried out in C. oleaginosus using CRISPR/Cas system. A tailored enzyme system isolated to degrade the C. oleaginosus cell wall enabled the isolation of viable spheroplasts that are amenable to in-cell delivery of nucleic acids and proteins. The employment of both Cas9 protein and Cas mRNA was effective in obtaining strains with URA5 knockout that did not exhibit growth in the absence of uracil. Subsequently, we successfully created several strains with enhanced lipid yield (54% increase compared to that in wild type) or modified fatty acid profiles comparable with those of cocoa butter or sunflower oil compositions.

Conclusion
This study establishes the first targeted engineering technique for C. oleaginosus using the CRISPR/Cas system. The current study creates the foundation for flexible and targeted strain optimizations towards building a robust platform for sustainable microbial lipid production. Moreover, the genetic transformation of eukaryotic microbial cells using Cas9 mRNA was successfully achieved.
The SoftHand Pro platform: a flexible prosthesis with a user-centered approach
Authors: Capsi-Morales Patricia , Piazza Cristina , Grioli Giorgio , Bicchi Antonio , Catalano Manuel G. 
Published: February 2023

Abstract
Background
Among commercially-available upper-limb prostheses, the two most often used solutions are simple hook-style grippers and poly-articulated hands, which present a higher number of articulations and show a closer resemblance to biological limbs. In their majority, the former type of prostheses is body-powered, while the second type is controlled by myoelectric signals. Body-powered grippers are easy to control and allow a simple form of force feedback, frequently appreciated by users. However, they present limited versatility. Poly-articulated hands afford a wide range of grasp and manipulation types, but require enough residual muscle activation for dexterous control. Several factors, e.g. level of limb loss, personal preferences, cost, current occupation, and hobbies can influence the preference for one option over the other, and is always a result of the trade-off between system performance and users’ needs.

Methods
The SoftHand Pro (SHP) is an artificial hand platform that has 19 independent joints (degrees-of-freedom), but is controlled by a single input. The design of this prosthesis is inspired by the concept of postural synergies in motor control and implemented with soft-robotic technologies. Their combination provides increased robustness, safe interaction and the execution of diverse grasps. The potential of the SHP is fully unleashed when users learn how to exploit its features and create an intimate relationship between the technical aspects of the prosthesis design and its control by the user.

Results
The great versatility of the SoftHand Pro (a reasearch protpotype) permitted its adaptation to the user requirements. This was experienced by the SoftHand Pro Team during the preparation for different CYBATHLON events (from 2016 to 2020). The mixed power and dexterous hand operations required by each task of the race is inspired by everyday tasks. Our prosthesis was driven by different pilots, with different habits and backgrounds. Consequently, the hand control modality was customized according to the user’s preferences. Furthermore, the CYBATHLON tasks had some variations in this period, promoting the continuous development of our technology with a user-centered approach. In this paper, we describe the participation and preparation of the SoftHand Pro Team from 2016 to 2020 with three pilots and two different activation modalities, hybrid body-controlled and myoelectric control.

Conclusions
We introduced our pilots, the implementation of the two control modalities, and describe the successful participation in all CYBATHLON events. This work proves the versatility of the system towards the user’s preferences and the changes in the race requirements. Finally, we discussed how the CYBATHLON experience and the training in the real-world scenario have driven the evolution of our system and gave us remarkable insights for future perspectives.
Fatal multiple organ dysfunction caused by commensal bacteria of urogenital tract infection in adult lung transplant recipients: two case reports
Authors: Tian Manman , Han Dongsheng , Ma Subo , Liu Tingting , Yang Wu , Zheng Xia 
Published: February 2023

Abstract
Background
Infection following lung transplantation has been the focus of clinical concerns. The colonization rate of commensal bacteria of the urogenital tract, including Mycoplasma hominis, Ureaplasma urealyticum (UU), and herpes simplex virus type-2 (HSV-2), is high, which may cause secondary infection after transplantation.

Case presentation
Twenty-three-year-old and 67-year-old women underwent lung transplantation for different causes. Shortly after the operation, they developed perineal skin ulcers, hypoxia, and intractable epilepsy. Subsequent computed tomography (CT) of the chest showed lung consolidation, and cranial CT showed shallowing sulci and gyri. UU and HSV-2 were detected in bronchoalveolar lavage fluid by next-generation sequencing, and HSV-2 was shown in the cerebrospinal fluid of both patients. Despite active treatment, both suffered irreversible brain function damage within 72 h of the seizure.

Conclusions
Clinicians should know that commensal bacteria of urogenital tract infections can lead to fatal multiple organ dysfunction after lung transplantation.
CT-based morphological study of the pelvis in patients with gluteal muscle contracture
Authors: Zhao Yikun , Dong Xueping , Zhao Zhen , Lv Maojiang , Li Shun , Zhang Xintao 
Published: February 2023

Abstract
Background
In the clinic, gluteal muscle contracture (GMC) causes pelvic structural changes, including acetabular retroversion. However, its causes and forms are not well understood. This study aimed to investigate and analyse the clinical significance of pelvic structural differences between GMC patients and healthy individuals.

Methods
As the GMC group, we identified 100 GMC patients who received treatment and met the inclusion criteria between January 2019 and January 2020. Control subjects were drawn from the hospital’s emergency trauma patients who had no history of pelvic or hip joint disease. All subjects underwent CT scans to measure their pelvic rotation, including the superior iliac angle (SIA), inferior iliac angle (IIA), and ischiopubic angle (IPA), and acetabular coverage, which includes anterior acetabular sector angle (AASA), posterior acetabular sector angle (PASA), horizontal acetabular sector angle (HASA), and superior acetabular sector angle (SASA).

Results
The SIA, IIA, IPA, and PASA of the GMC group were considerably smaller than those of the control group, while the AASA of the GMC group was higher, indicating a statistically significant difference (P < 0.05). The HASA and SASA of the GMC group, on the other hand, were not considerably different from those of the control group. The angles in the GMC group were relativized as follows: The HASA had a positive correlation with the AASA and PASA (r = 0.750, P < 0.01; r = 0.749, P < 0.01); the SASA had a positive correlation with the AASA, PASA, and HASA (r = 0.555, P < 0.01; r = 0.273, P < 0.01; r = 0.552, P < 0.01); the AASA had a negative correlation with the SIA, IIA and IPA (r = − 0.355, P < 0.01; r = − 0.551, P < 0.01; r = − 0.30, P < 0.01); the PASA had a positive correlation with the IIA (r = 0.315, P < 0.01) and had no correlation with the SIA and IPA (P > 0.05); and the IIA had a positive correlation with both the SIA and IPA (r = 0.664, P < 0.01; r = 0.465, P < 0.01).

Conclusion
Individuals with GMC have an abnormal pelvic morphology, with acetabular retroversion caused by ilial rotation rather than dysplasia of the acetabular wall.