bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prognostic role of preoperative inflammatory markers in postoperative patients with colorectal cancer
Authors: Xiao Zilong , Wang Xinxin , Chen Xiaoxiao , Zhou Jiawei , Zhu Haitao , Zhang Jiangnan , Deng Wensheng 
Published: March 2023

BackgroundInflammatory response markers are prognostic factors for several cancers, but their role in postoperative colorectal cancer (CRC) is unclear. The purpose was to evaluate the role of preoperative Neutrophil-to-Lymphocyte ratio (NLR), Platelet-to-Lymphocyte-ratio (PLR), and Lymphocyte-to-Monocyte ratio (LMR) in the prognosis of postoperative CRC patients.MethodsWe retrospectively reviewed 448 CRC patients who had undergone surgical resection from December 2015 to December 2017 in our hospital. The plasma NLR, PLR, LMR, CEA, and CA19-9 were collected within 2 weeks before the operation. We recorded the clinical characteristics and survival data by reviewing medical records and phone calls. We analyzed preoperative inflammatory markers and clinical features using Pearson chi-squared tests or Fisher’s tests. Uni- and multivariate Cox regression analyses were performed, and overall survival (OS) was estimated with the Kaplan–Meier method.ResultsHigh NLR and PLR were associated with worse overall survival in postoperative CRC (HR = 2.140, 95%CI = (1.488-3.078), P &lt; 0.001; HR =1.820, 95%CI = (1.271-2.605), P = 0.001). High LMR was associated with improved overall survival in postoperative CRC (HR = 0.341, 95%CI = (0.188-0.618), P &lt; 0.001). In the multivariate regression analysis, the increase of NLR resulted in an increase in the risk of death (HR = 1.678, 95%CI = (1.114-2.527), P = 0.013), and for the LMR, a reduction of the risk of death (HR = 0.480, 95%CI = (0.256 - 0.902), P = 0.023). Moreover, TNM stage, CA-199, CEA, nerve or vascular invasion (NVI) and adjuvant chemotherapy after surgery also were associated with worse overall survival in postoperative CRC.ConclusionCurrent evidence indicates that preoperative inflammatory markers NLR, LMR, and PLR are associated with overall survival in postoperative patients with colorectal cancer. NLR is an independent risk factor, and LMR is an independent protective factor in CRC patients after surgery.
Development and validation of a nomogram model for lung cancer based on radiomics artificial intelligence score and clinical blood test data
Authors: Hu Wenteng , Zhang Xu , Saber Ali , Cai Qianqian , Wei Min , Wang Mingyuan , Da Zijian , Han Biao , Meng Wenbo , Li Xun 
Published: March 2023

BackgroundArtificial intelligence (AI) discrimination models using single radioactive variables in recognition algorithms of lung nodules cannot predict lung cancer accurately. Hence, we developed a clinical model that combines AI with blood test variables to predict lung cancer.MethodsBetween 2018 and 2021, 584 individuals (358 patients with lung cancer and 226 individuals with lung nodules other than cancer as control) were enrolled prospectively. Machine learning algorithms including lasso regression and random forest (RF) were used to select variables from blood test data, Logistic regression analysis was used to reconfirm the features to build the nomogram model. The predictive performance was assessed by performing the receiver operating characteristic (ROC) curve analysis as well as calibration, clinical decision and impact curves. A cohort of 48 patients was used to independently validate the model. The subgroup application was analyzed by pathological diagnosis.FindingsA total of 584 patients were enrolled (358 lung cancers, 61.30%,226 patients for the control group) to establish the model. The integrated model identified eight potential factors including carcinoembryonic antigen (CEA), AI score, Pro-Gastrin Releasing Peptide (ProGRP), cytokeratin 19 fragment antigen21-1(CYFRA211), squamous cell carcinoma antigen(SCC), indirect bilirubin(IBIL), activated partial thromboplastin time(APTT) and age. The area under the curve (AUC) of the nomogram was 0.907 (95% CI, 0.881-0.929). The decision and clinical impact curves showed good predictive accuracy of the model. An AUC of 0.844 (95% CI, 0.710 - 0.932) was obtained for the external validation group.ConclusionThe nomogram model integrating AI and clinical data can accurately predict lung cancer, especially for the squamous cell carcinoma subtype.
Cartilaginous predictors of residual acetabular dysplasia (RAD) in developmental dysplasia of the hip following closed or open reduction: A systematic review and meta-analysis
Authors: Yang Shuai , Su Fei , Jia Hao-Ruo , Liu Chen-Xin , Lu Qing-Da , Yang Ya-Ting , Liu Yong , Wang Jia-Ju , Jie Qiang 
Published: March 2023

ObjectThis study was designed to analyze the cartilaginous predictors of residual acetabular dysplasia (RAD) after early treatment of developmental dysplasia of the hip and their diagnostic accuracy.Study designDatabases such as PubMed, Embase, Cochrane, and Web of science were searched to screen the literature. The quality of the literature was assessed by the QUADAS-2 tool. Qualitative and quantitative synthesis of literature were performed based on extracted data. For quantitative synthesis studies, the sensitivity, specificity, diagnostic odds ratio (DOR), and summary receiver operating characteristic (SROC) curve with corresponding confidence intervals were calculated.ResultsFor the cartilaginous acetabular index (CAI) group, the combined values of sensitivity, specificity, and DOR were 0.80 (95% CI = 0.54–0.93), 0.73 (95% CI = 0.57–0.84), and 10.62 (95% CI = 3.96–28.53), respectively. The corresponding values in the cartilaginous center-edge angle (CCE) group were 0.71 (95% CI = 0.57–0.82), 0.78 (95% CI = 0.66–0.87), and 8.64 (95% CI = 3.08–24.25), respectively. The area under the curve (AUC) of SROC was 0.82 (95% CI = 0.78–0.85) and 0.80 (95% CI = 0.76–0.83) for the CAI and CCE groups. The CAI group had higher sensitivity, DOR, and AUC than the CCE group.ConclusionBoth of these two groups have good diagnostic accuracy, and CAI/L-AI has a little edge over CCE/L-CEA. However, there is still more research needed to determine whether they can be used as independent indications for secondary orthopedic surgery.Systematic review registration: [https://www.crd.york.ac.uk/PROSPERO/], identifier: [CRD42022338332].
Bacterial growth and ceftriaxone activity in individual ascitic fluids in an in vitro model of spontaneous bacterial peritonitis
Authors: van Os Wisse , Wulkersdorfer Beatrix , Eberl Sabine , Oesterreicher Zoe , Schwabl Philipp , Reiberger Thomas , Paternostro Rafael , Weber Maria , Willinger Birgit , Zeitlinger Markus 
Published: March 2023

Introduction: The environment of the infection site affects bacterial growth and antibiotic activity. When bacterial growth and antibiotic activity are studied in body fluids, samples of multiple subjects are usually pooled, averaging out potentially relevant differences in composition. The ascitic fluid (AF) environment is frequently associated with spontaneous bacterial peritonitis (SBP) in cirrhotic patients. In this study, bacterial growth and ceftriaxone activity were evaluated in individual AF using an in vitro model of SBP, reflecting the environment and pharmacokinetics at the infection site.Methods: AF was obtained from nine cirrhotic patients with non-infected ascites. Growth of nine bacterial strains (three Escherichia coli, four Staphylococcus aureus, one Enterococcus faecalis, and one Klebsiella pneumoniae) in individual AF was assessed and correlated with biomarkers including potential risk factors for SBP. Ceftriaxone time-kill experiments, in which the pharmacokinetic profile observed in AF following a 1 g intravenous infusion was replicated, were performed with two E. coli and two S. aureus isolates with minimum inhibitory concentrations around the ceftriaxone resistance breakpoint.Results: Significant correlations were found between bacterial growth and AF levels of protein (Spearman’s rank correlation coefficient ρ = −0.35), albumin (ρ = −0.31), and complement C3c (ρ = −0.28), and serum levels of bilirubin (ρ = 0.39) and aspartate aminotransferase (ρ = 0.25). Ceftriaxone was active in AF, even against resistant isolates, generally resulting in ≥2 log reductions in bacterial count within 24 h.Conclusion: Ascites patients may be predisposed to or protected against SBP based on the antimicrobial capacity of their AF. Ceftriaxone at clinical AF concentrations is active in the AF environment.
Inclusive physical activity games at school: The role of teachers’ attitude toward inclusion
Authors: Gentile Ambra , Giustino Valerio , Rodriguez-Ferrán Olga , La Marca Alessandra , Compagno Giuseppa , Bianco Antonino , Battaglia Giuseppe , Alesi Marianna 
Published: March 2023

IntroductionInclusive physical activity games at school can be useful for teachers dealing with students with disabilities. The use of inclusive strategies and games can be directly linked to teachers’ self-efficacy and familiarity with the inclusive strategies, while it could be indirectly influenced by their attitude toward inclusion and, in a smaller part, by social desirability in their response. Moreover, teachers’ responses could be different among the different school grades. Therefore, the aim of the current study is to investigate the role of attitude toward inclusion, social desirability, self-efficacy, and familiarity in the use of physical activity games at school in teachers from all school grades.MethodsA sample of 1,583 schoolteachers was asked to fill out a questionnaire about their perceptions of governmental measures, self-efficacy, familiarity with inclusive strategies through physical activity, and two standardized questionnaires assessing attitudes toward inclusion and social desirability.ResultsTeachers from primary school reported lower scores in attitude toward inclusion total score and dimensions, namely impact on teacher, impact on the environment, impact on the other children, and impact on the student with disability. Moreover, the path analysis model showed that the attitude toward inclusion indirectly influenced the use of inclusive strategy and had a small direct effect on familiarity with inclusive strategies and self-efficacy. Social desirability slightly influenced both familiarity and self-efficacy but not the use of inclusive strategies. Familiarity and self-efficacy had a direct effect on the use of inclusive physical activity games.DiscussionThe results of the current study suggest that being familiar with and having a high self-efficacy in implementing inclusive strategies are well related to the use of inclusive strategies at school. In addition, more attention should be given to kindergarten and primary school teachers, who reported lower scores in the attitude toward inclusion and higher scores in social desirability.
Global narratives on unequal outcomes produced by lockdown in Africa: A social science perspective on the “one-size-fits all” COVID-19 response
Authors: Grant Catherine , Sams Kelley 
Published: March 2023

IntroductionLockdown measures were introduced worldwide to prevent the spread of COVID-19, and several studies showed the positive impacts of these policies in places such as China and Europe. Many African governments also imposed lockdowns at the beginning of the pandemic. These lockdowns met with mixed reactions; some were positive, but others focused on concerns about the consequences of lockdowns.MethodsIn this article, we use social listening to examine social media narratives to investigate how people balanced concerns about preventing the spread of COVID-19 with other priorities. Analyzing social media conversations is one way of accessing different voices in real time, including those that often go unheard. As internet access grows and social media becomes more popular in Africa, it provides a different space for engagement, allowing people to connect with opinions outside of their own conceptual frameworks and disrupting hierarchies of how knowledge is shaped.ResultsThis article indicates which narratives were favored by different organizations, stakeholders, and the general public, and which of these narratives are most dominant in policy discourses. The range of narratives is found to be reflective of the blindness to inequality and social difference of much decision-making by policymakers.DiscussionThus, contrary to the “we are all in this together” narrative, diseases and public health responses to them clearly discriminate, accentuating long-standing structural inequalities locally, nationally, and globally, as well as interplaying with multiple, dynamic, and negotiated sources of marginalization. These and other insights from this article could play a useful role in understanding and interpreting how social media could be included in pandemic preparedness plans.
A mixed methods approach to obtaining health care provider feedback for the development of a Canadian pediatric dental caries risk assessment tool for children <6 years
Authors: Schroth Robert J. , Kyoon-Achan Grace , Levesque Josh , Sturym Melina , DeMaré Daniella , Mittermuller Betty-Anne , Lee Juyoung , Lee Victor Ho Kong 
Published: March 2023

IntroductionEarly childhood caries (ECC) is a chronic but preventable disease affecting young children worldwide. Many young children face access to care barriers to early preventive dental visits for a variety of reasons, which can increase their risk for ECC. Non-dental primary health care providers are well positioned to assist in assessing a child's risk for ECC by performing caries risk assessment (CRA). The purpose of this project was to report on primary health care provider and stakeholder feedback in order to refine a drafted CRA tool for Canadian children &lt;6 years of age intended for use by non-dental primary health care providers.MethodsIn this mixed methods project, we conducted six focus groups with primarily non-dental primary health care providers followed by a short paper-based survey to quantify preferences and feedback. Data were thematically and descriptively analyzed.ResultsParticipants’ feedback on the drafted CRA tool included the need for it to be relatively quick to complete, easy and practical to score, easy to implement into practitioners’ clinic schedules, and to include anticipatory guidance information to share with parents and caregivers. All participants (100%) welcomed a CRA tool. Many (85.4%) liked a layout that could be added to tools they already utilize. Most (73.2%) wanted the tool to be in colour, and many (90.2%) wanted the tool to include pictures.ConclusionNon-dental primary health care providers informed the final development and layout of the newly released Canadian CRA tool. Their feedback resulted in a user-friendly CRA tool with provider-patient dynamics and preferences.
Duodenum-preserving pancreatic head resection compared to pancreaticoduodenectomy: A systematic review and network meta-analysis of surgical outcomes
Authors: Guo Shixiang , Zhou Qiang , Yang Jiali , Tao Junyu , Zhang Junfeng , Wang Huaizhi 
Published: March 2023

ObjectivesIn this systemic review and network meta-analysis, we investigated pancreaticoduodenectomy (PD), pylorus-preserving pancreaticoduodenectomy (PPPD), and different modifications of duodenum-preserving pancreatic head resection (DPPHR) to evaluate the efficacy of different surgical procedures.MethodsA systemic search of six databases was conducted to identify studies comparing PD, PPPD, and DPPHR for treating pancreatic head benign and low-grade malignant lesions. Meta-analyses and network meta-analyses were performed to compare different surgical procedures.ResultsA total of 44 studies were enrolled in the final synthesis. Three categories of a total of 29 indexes were investigated. The DPPHR group had better working ability, physical status, less loss of body weight, and less postoperative discomfort than the Whipple group, while both groups had no differences in quality of life (QoL), pain scale scores, and other 11 indexes. Network meta-analysis of a single procedure found that DPPHR had a larger probability of best performance in seven of eight analyzed indexes than PD or PPPD.ConclusionDPPHR and PD/PPPD have equal effects on improving QoL and pain relief, while PD/PPPD has more severe symptoms and more complications after surgery. PD, PPPD, and DPPHR procedures exhibit different strengths in treating pancreatic head benign and low-grade malignant lesions.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/, identifier: CRD42022342427.
Characteristics of the paravertebral muscle in adult degenerative scoliosis with PI-LL match or mismatch and risk factors for PI-LL mismatch
Authors: Guo Jichao , Xie Dongxiao , Zhang Jinniu , Ding Wenyuan , Zhao Boyang , Li Zhaohui , Huo Yachong 
Published: March 2023

ObjectivePelvic incidence (PI) minus the lumbar lordosis (LL) angle (PI-LL) correlates with function and disability. It is associated with paravertebral muscle (PVM) degeneration and is a valuable tool for surgical planning of adult degenerative scoliosis (ADS). This study aims to explore the characteristics of PVM in ADS with PI-LL match or mismatch and to identify the risk factors for PI-LL mismatch.MethodsA total of 67 patients with ADS were divided into PI-LL match and mismatch groups. The visual analog scale (VAS), symptom duration, and Oswestry disability index (ODI) were used to assess patients’ clinical symptoms and quality of life. The percentage of fat infiltration area (FIA%) of the multifidus muscle at the L1-S1 disc level was measured by using MRI with Image-J software. Sagittal vertical axis, LL, pelvic tilt (PT), PI, sacral slope, and the asymmetric and average degeneration degree of the multifidus were recorded. Logistic regression analysis was done to identify the risk factors for PI-LL mismatch.ResultsIn the PI-LL match and mismatch groups, the average FIA% of the multifidus on the convex side was less than that on the concave side (P &lt; 0.05). There was no statistical difference of asymmetric degeneration degree of the multifidus between the two groups (P &gt; 0.05). In the PI-LL mismatch group, the average degeneration degree of the multifidus, VAS, symptom duration, and ODI were significantly higher than that in the PI-LL match group, respectively (32.22 ± 6.98 vs. 26.28 ± 6.23 (%), 4.33 ± 1.60 vs. 3.52 ± 1.46, 10.81 ± 4.83 vs. 6.58 ± 4.23 (month), 21.06 ± 12.58 vs. 12.97 ± 6.49, P &lt; 0.05). The average degeneration degree of the multifidus muscle was positively correlated with the VAS, symptom duration, and ODI, respectively (r = 0.515, 0.614, and 0.548, P &lt; 0.05). Sagittal plane balance, LL, PT, and the average degeneration degree of the multifidus were the risk factors for PI-LL mismatch (OR: 15.447, 95% CI: 1.274–187.269; OR: 0.001, 95% CI: 0.000–0.099; OR: 107.540, 95% CI: 5.195–2,225.975; OR: 52.531, 95% CI: 1.797–1,535.551, P &lt; 0.05).ConclusionThe PVM on the concave side was larger than that on the convex side in ADS irrespective of whether PI-LL matched or not. PI-LL mismatch could aggravate this abnormal change, which is an important cause of pain and disability in ADS. Sagittal plane imbalance, decreased LL, higher PT, and larger average degeneration degree of the multifidus were independent risk factors for PI-LL mismatch.
Pulling the Plug—Draining an Alpine Lake Failed to Eradicate Alien Minnows and Impacted Lower Trophic Levels
Authors: Schabetsberger Robert , Jersabek Christian D. , Maringer Alexander , Kreiner Daniel , Kaltenbrunner Magdalena , Blažková Pavlína , Pokorný Petr , Denoël Mathieu , Emmerstorfer Heimo , Lipovnik Cvetka , Wölger Herbert 
Published: March 2023

Fish introduction into fishless high-altitude lakes has detrimental effects on biodiversity. Removal of alien fish through intensive fishing is cost-intensive and difficult to achieve in productive lakes. Lake Sulzkarsee is the only lake in the National Park Gesäuse, Austria, and was an important breeding site for amphibians until the lake was stocked with fish in the late 1970s. Salmonids were eradicated in 2005, but the lake remained degraded by the introduced minnows (Phoxinus sp.). In 2018, the lake was drained through a siphon pipe and then by pumping out water with dirt water pumps. The deepest part was treated with slaked lime, but several hundred adult minnows survived in sediment crevices and reproduced in the following season. After drainage, the phytoplankton biomass increased. Indicator species, such as Daphnia longispina and amphibians, showed signs of recovery, but they went back to an impacted state when minnows recovered after the failed eradication attempt. Purse seines proved to be the most efficient gear to catch minnows. These results indicate that deep mountain lakes are difficult to drain efficiently. Sediment treatment is required to eliminate all fish.
Revisão sistemática de ensaios clínicos randomizados para reabilitação funcional do traumatismo cranioencefálico
Authors: Lopes de Souza Gabriela , Menezes-Reis Rafael 
Published: March 2023

Introdução. O processo de reabilitação de pacientes afetados pelo traumatismo cranioencefálico (TCE) possibilita uma melhor recuperação, tanto motora quanto funcional, além de promover qualidade de vida em pacientes, porém não há um consenso sobre quais modalidades de tratamento fisioterapêutico podem ser empregados. Objetivo. Realizar uma revisão sistemática para avaliar as modalidades fisioterapêuticas que reestabeleçam a função de forma mais efetiva no tratamento de pacientes com TCE. Método. Este é um estudo de revisão sistemática, cuja coleta foi realizada nas bases de dados MEDLINE (via PubMED) e na PEDro entre novembro de 2021 e maio de 2022. Para as buscas foram utilizados os seguintes termos de busca “traumatic brain injury” AND “physiotherapy”; na Physiotherapy Evidence Database (PEDro), acrescenta-se o preenchimento dos campos de pesquisa avançada disponíveis no portal. Foram incluídos apenas ensaios clínicos controlados aleatorizados completos. Os artigos selecionados foram avaliados de acordo com a Escala PEDro, a fim de quantificar a qualidade metodológica dos estudos a partir dos critérios de avaliação da referida escala. Resultados. Foram encontrados 233 artigos, onde 223 foram excluídos e 10 artigos restaram para serem analisados e tabulados. Conclusão. O atendimento fisioterapêutico baseado em exercícios foi eficaz em reestabelecer a função dos pacientes. Entretanto, os estudos indicam uma grande diversidade de condutas empregadas, não havendo superioridade de um tratamento em relação a outro.
PENGARUH KOMPETENSI DAN PRAKTEK AKUNTABILITAS TERHADAP PENCEGAHAN KECURANGAN (FRAUD) DALAM PENGELOLAAN DANA DESA DENGAN MORALITAS INDIVIDU SEBAGAI VARIABEL PEMODERASI
Authors: Risakotta Kathleen Asyera 
Published: March 2023

<p align="Justify">This study aimed to examine the effect of competence and accountability practice on fraud prevention in the management of village funds with morality as a moderating variable. This study uses the questionnaire survey. Analysis of data using Moderated Regression Analysis (MRA). The results showed that competence and accountability practices significant effect on fraud prevention in the management of village funds. Individual Morality is able to moderate and competence on fraud prevention in the management of village funds. Individual Morality does not moderate accountability practice on fraud prevention in the management of village funds.</p><p><strong>Key words:</strong> Competence, Accountability Practice, Individual Morality, Fraud Prevention, Moderated Regression Analysis</p>