bluuebunny/crossref_metadata_2025_split huggingface dataset:
Treatment of osteonecrosis of the femoral head using prevascularized bone tissues constructed with human umbilical cord mesenchymal stem cells and human umbilical vein endothelial cells
Authors: ren qiang , Chai Miaomiao , Chen Kaijia , Yuzhe GUO , Yan ZHOU , Ning CAO , Yu Chenxi 
Published: August 2023

Abstract

Background：
Studies have shown that osteonecrosis of the femoral head (ONFH)is related to bone marrow mesenchymal stem cell injury and microvascular injury. Early ONFH patients can choose core decompression and other treatments, but the clinical effect is poor. In recent years, tissue engineering technology based on mesenchymal stem cells is a new method to treat ONFH. In addition, whether the transplantation area is fully vascularized also affects whether the mesenchymal stem cells can play a repair role. In this study, we constructed prevascularized bone tissue based on human umbilical cord mesenchymal stem cells and human umbilical vein endothelial cells to evaluate the therapeutic effect of prevascularized bone tissue on ONFH.
Objective:
This paper is to investigate the effect of pre-vascularized bone tissue constructed by human umbilical cord mesenchymal stem cells and human umbilical vein endothelial cells on bone repair of necrotic femoral head, so as to provide theoretical basis for clinical treatment of necrotic femoral head.
Methods:
The rabbits were randomly divided into 5 groups, of which, 1 group was not given any intervention, while rabbit femoral head necrosis models were prepared for the other 4 groups by microwave heating method and they are respectively named mould-making group, static bone tissue group, dynamic bone tissue group and pre-vascularized bone tissue group according to the different substances injected into the femoral head. Various tests, including MRI, Micro-CT, HE staining and immunofluorescence staining, were performed after the animals were executed 8 weeks after treatment to assess the osteogenic ability of the implant and the repair effect of necrotic femoral head.
Results:
Various tests showed that the pre-vascularized bone tissue group had better ability to promote necrotic femoral head repair, and significant new bone formation and bone quality improvement occurred 8 weeks after surgery. The static bone tissue group and dynamic bone tissue group were similar in their ability to promote femoral head repair, with all the three groups outperforming the modeled group.
Conclusions:
The pre-vascularized bone tissue has a good effect on promoting the reconstruction of necrotic femoral head and shows superior osteogenesis, angiogenesis and bone repair effect. It is thus a good graft material for repairing necrotic femoral head and is of great value in the treatment of necrotic femoral head.
Clinical characteristics and relevant factor analysis in super-aged COVID-19 patients
Authors: Xiaorong MA , Tian Zheng , guliru aresilan , rukeyamu abudu shalamu , Jianfeng Zhang , Bin Dai 
Published: August 2023

Abstract
Objective
To explore the clinical characteristics and analyze the relevant factors of super-aged patients with coronavirus disease 2019 (COVID-19).
Methods
Clinical manifestations, laboratory findings, imaging data, treatments, and outcomes of 366 aged patients (aged ≥ 80 years) with COVID-19 hospitalized and treated at the Eighth Affiliated Hospital of Xinjiang Medical University between August 2022 and December 2022 were collected.
Results
This study include a total of 235 males (64.2%) and 131 females (35.8%), with an average age of 88.7 ± 1.8 years. The levels of C-reactive protein (CRP) and procalcitonin (PCT) were higher and the lymphocyte count was lower in severe patients compared to mild patients. Serum albumin (ALB), prealbumin, hemoglobin (Hb), the nutritional risk screening 2002 (NRS2002) score, the Padua score, and the activities of daily living (ADL) score were substantially lower in severe patients compared to mild patients. Age, Hb level, and ADL score were linked with the progression to severe COVID-19. The vaccination percentage was much lower in severe patients than in mild patients, and the use of antibiotics and mechanical ventilation through tracheal intubation was considerably higher in severe patients than in mild patients.
Conclusion
Super-aged COVID-19 patients with cardiovascular or cerebrovascular diseases, chronic pulmonary diseases, or chronic renal diseases had a higher risk of progression to severe pneumonia,lung CT scanning showed more severe manifestations, and the risk of complications including mixed infection, malnutrition, and mechanical ventilation through tracheal intubation was higher. The vaccination percentage was low among severe patients. Comprehensive treatments should be performed in super-aged COVID-19 patients to improve the outcomes.
Combined Air-Wall Guided GDI Engine Performance and Emissions Control with E20 and Hydrogen Blended Fuel
Authors: NAGAREDDY SHIVAKUMAR , GOVINDASAMY KUMARESAN , RAJARAM KAMATCHI 
Published: August 2023

Abstract
GDI engine plays an important role in achieving the existing emission standards with spray guided combustion chamber geometry and high fuel injection pressure of gasoline (or) gasoline-ethanol blended fuel. In this study, the combined air-wall guided CC (combustion chamber) geometry of modified GDI engine was used to analyze the performance and emission characteristics with E20 and Hydrogen blended fuel. An engine performance and emission tests were carried out with pure gasoline fuel, E20 blended fuel and E20-Hyrogen fuel blend at a compression ratio of 9.8:1 and constant speed of 1500 rpm under different engine torque values. The test results of E20-Hydrogen blended fuel were compared with E20 and pure gasoline fuels; all the performance and emission parameters of E20-Hydrogen blend fuel shown better results than that of E20 and pure gasoline, except the brake specific NOx emission concentration from E20-Hydrogen fuel blend was shown slightly higher than E20 blended fuel. Bake specific Soot particle emission shown maximum reduction of 78.46% when compared with pure gasoline.
An integrative analysis reveals the prognostic and immunological role of TIMP gene family in pan-cancer
Authors: Wang Jiaxin , Zhang Zexin , Fan Yueying , Jia Chiyu , Chen Zhaohong , Chen Xiaodong , Shen huidan , Zhang Fei , Luo zhong , Liu Yankuo 
Published: August 2023

Abstract

Cancer is a serious disease that threatens human health. Radiation, chemotherapy, and surgical excision are the main strategies used to treat tumors. However, important targets and vital genes have gradually come to light. TIMPs, inhibitors of the matrix metalloproteinase, were related to tumor progression. It is still uncertain, nevertheless, how they affect the progression and prognosis of pan-cancer. Therefore, the profiles of TIMP gene family expression in various cancers were evaluated via The Cancer Genome Atlas (TCGA) database. The prognostic value of the TIMP gene family was investigated by K-M plotter and Cox regression analysis. Additionally, we explored the association among TIMP gene family expression level, immune cell infiltration, immune-related genes, and linked pathways. We found in several malignancies, there were notable differences in the TIMP gene family expression levels between tumor and normal tissues. Meanwhile, a prognosis study revealed clear connections between the the TIMP gene family expression and the clinical prognosis of cancer patients in many cancers. Additionally, the TIMP gene family expression was associated with the infiltration of immune cells, especially macrophages. Thus, we proposed the TIMP gene family could be addressed as novel biomarkers for determining prospective prognostic values and potential therapeutic targets for cancer patients.
The student-patient relationship during hospitalization and patient participation in clinical classes.
Authors: Kaliszewski Krzysztof , Makles Szymon , Frątczak Agnieszka , Kisiel Michał , Lipska Patrycja , Stebel Agata 
Published: August 2023

Abstract
Background
A crucial aspect of the education of prospective medical professionals is their interaction with patients. Thus, this study sought to investigate how patients perceive this relationship. The aim was to obtain insights from patients regarding the optimal conduct and demeanor of medical students during clinical classes, with the ultimate objective of maximizing patient comfort.
Methods
The authors collected a total of 403 surveys from patients of a teaching hospital, regarding their perception of students as healthcare providers.
Results
Our research results reveal considerable variance in responses based on the age distribution of patients. Notably, the senior demographic prioritizes the external presentation of students and the utilization of courteous language. In contrast, younger patients exhibit less interest in participating in educational sessions with students. Notably, the majority of patients perceive their involvement in the education of future healthcare professionals to be essential.
Conclusions
Patients voluntarily engage in educational classes with students. The relationship between patients and students is amicable, and the majority of students display a respectful demeanor toward patients. Nonetheless, preserving patient confidentiality and ensuring the proper management of classes remain persistent issues.
Waste ‘Nagpur Orange’ Peel Essential Oil for Improved Performance, Gut Health and Immune Response In Broiler Chicken: In Vivo Studies
Authors: Deshpande Kuldeep Yeshwant , Gore Someshwar Madhukar , Mandavgane Sachin Arvind , Shinde Pratik Narendra , Patil Madhura Rajendra , Chakravarty Ipsita , Zadgaonkar Laxmi Akshay , Borkar Anshul Manik , Vedpathak Ashish , Kamdi Bhupesh Purushottam , Kale Dnyaneshwar Balasaheb 
Published: August 2023

Abstract

Essential oil with 91.88% limonene extracted from waste Nagpur orange peels using indigenously designed and patented extraction mechanism was used to investigate effect of its supplementation on performance, immune response and gut health in broilers. 300 chicks (VenCobb-430) were distributed in 5 groups having 15 chicks per replicate using completely randomized design. The diet was formulated as per BIS (2007) standards for control, while antibiotic was added in T₁ @ 500g/ton and orange peel essential oil (OPEO) @ 50, 100, 150g/ton were added in T2, T3and T4respectively. The cumulative feed intake, body weights and FCR for overall period was significant (P < 0.05). The percent nutrient metabolisability improved numerically and NFE metabolisability was significantly higher (P < 0.05) in treatment groups. Carcass characteristics and sensory attributes were not affected (P > 0.05) except gizzard weight. The hematological parameters remained comparable (P > 0.05); while LPO improved significantly (P < 0.05) in OPEO supplemented groups. The total protein, albumin, A:G ratio and uric acid remained comparable (P > 0.05); while globulin improved significantly (P < 0.05) in OPEO supplemented groups. The serum antibody titre against RD virus, bursa and spleen weight was significantly higher (P < 0.05) in T3. Morphometry of intestine and liver remained comparable; however, lung morphometry altered significantly (P < 0.05). Hence, it is concluded that dietary supplementation of OPEO at 100g/ton improved performance, gut health and immune response of broilers. To the best of our knowledge, this is the first attempt to evaluate the effect of essential oil extracted from Nagpur orange peels in broilers.
A 43-year of human thermal comfort in Central Africa.
Authors: Kaissassou Samuel , Komkoua A.J. , Guenang M. , Ngohe-Ekam P-S. , Njouenwet I. , Rigong H. 
Published: August 2023

Abstract
In this study, the human thermal stress was quantified across Central Africa (C.A) using the Universal Thermal Climate Index (UTCI). Although many of the documented studies on the use of UTCI in relation to human health are currently restricted to countries in the northern hemisphere, this contribution constitutes a prerequisite of information for future research in the region. To mitigate the problem of lack of field data in the Central African sub-region, we downloaded UTCI data via the ERA5 reanalysis portal. Based on this data source, we have explored the spatiotemporal characteristics and the resulting behaviour at annual, seasonal and monthly scales in Central Africa over the period 1982 to 2022. On these different scales, 4 of the 10 UTCI thermal stress categories were experienced, ranging from mild cold stress to strong heat stress. Spatially, cases of moderate heat stress were the most widespread, with cases of strong intensity occurring in a few isolated areas in the centre, east and west. Slight cold stress is confined to the south-east domain, particularly in autumn and winter. From 1982 to 2022, heat stress has increased significantly in the region, with peaks observed in January and October; very few areas have been spared the phenomenon of thermal stress. However, a slight decreasing trend was noticed along coastal regions and the south of C.A. Thereafter, the trends values showed the degree of C.A. vulnerability to global warming, and thus appropriate measures should be taken in relation to outdoor occupations and its impacts on the population of this region.
Iberian wolf’s diet and its quality during breeding season: exploring the influence of zone, wolf groups, prey availability and individual factors
Authors: Barja Isabel , Piñeiro Ana , Talegón Javier , Ruiz-González Aritz , Navarro-Castilla Álvaro , Caro Amaia , Gago-Barja Toni , Hernández M. Carmen 
Published: August 2023

Abstract
Large predators are essential in maintaining ecosystem functioning, and comprehending how their feeding habits change across natural and human-dominated landscapes is crucial to preserve biodiversity. In this study, the diet of Iberian wolves (Canis lupus signatus) during pup rearing season (July to September) has been studied in relation to prey abundance and putting emphasis in the analysis of the differences between zones, wolf groups and individual factors (age, sex and social status). For this, non-invasive monitoring was carried out in three zones of Spain where nine different wolf breeding groups were detected (Galicia, n = 4; Zamora, n = 4 and Valladolid, n = 1). Faecal samples were collected near rendezvous sites for dietary and genetic analyses, registering if it was or not a scent mark to know the social status of the individuals. Prey availability was determined by camera trapping or requesting the official census of wild prey in the study areas. We found differences in wolf’s diet depending on the zone and the breeding group however, the diet did not vary depending on the age, sex and social status. In general, Iberian wolves mainly fed on wild ungulates (wild boar, roe deer and red deer), feeding on the most abundant prey, except for Baldriz group in Galicia which seems to be specialized in hunting roe deer. Domestic animals’ consumption (sheep, goat, donkey, pig) was not high, but it occurred specially in agriculture and livestock areas (Ferreras in Zamora and Valladolid) where wild prey were less available.
Performance of the double-thin-shell approach for studying nighttime mediumscale traveling ionospheric disturbances using two dense GNSS observation networks in Japan
Authors: Fu Weizheng , Otsuka Yuichi , Shinbori Atsuki , Nishioka Michi , Perwitasari Septi 
Published: August 2023

Abstract
Electrodynamic coupling between the ionospheric E and F regions is widely recognized as the underlying mechanism for generating medium-scale traveling ionospheric disturbances (MSTIDs) during nighttime at midlatitudes. Recently, the double-thin-shell approach has proven to be a useful tool for studying the E-F coupling. By using total electron content (TEC) measurements, this approach enables the simultaneous reconstruction of electron density perturbations in both the E and F regions with broad and continuous coverage. However, the current reconstruction performance is limited when using only GPS-TEC measurements from GEONET, a dense network of groundbased Global Navigation Satellite System (GNSS) receivers over Japan. The expansion of available data sources and the integration of multi-GNSS observation data are considered important to enhance the double-thin-shell model. Fortunately, SoftBank Corp., a Japanese telecommunications provider, has recently developed a dense independent GNSS observation network to improve positioning services. In this paper, we analyze the potential of the improved double-thin-shell approach and emphasize the importance of incorporating multi-GNSS observation data from both GEONET and SoftBank networks. The solvability analysis, simulation, and observation results collectively indicate a substantial improvement in the spatiotemporal resolution. Specifically, the longitudinal and latitudinal resolution is improved from 0.15∘ to 0.1∘ in the E region, and from 0.5∘ to 0.3∘ in the F region. The temporal resolution is also improved from 2 minutes to 1 minute. In addition, significant improvements have been achieved in the reconstruction performance, particularly for the E region under complex background conditions. Based on these assessments, we conclude that the incorporation of GEONET and SoftBank GNSS observation data holds significant potential for improving the double-thin-shell model and advancing our understanding of MSTIDs.
Enhancement of Intra-Cardiac Flow-Field Data Using Adaptive Kernel Filtering
Authors: Banerjee Shataneek , Ghosh Amardip , Pal Prasanta 
Published: August 2023

Abstract
A method of determining the optimal kernel size for filtering noise in vortex dominated flow-fields, as found in the cardiac chambers is presented in this paper. Using synthetic flow fields generated using harmonic functions and perturbed using Gaussian noises of different amplitudes and spreads, the effect of kernel size on noise removal using the Median filter is tested systematically. It is shown that there exists an optimal kernel size at which the Median filter works best. The size of the optimal kernel is shown to be related to the vortex size. When applied to MRI generated cardiac flow-fields, the approach is seen to reveal underlying vortex patterns thereby aiding as an effective tool in the diagnosis and prognosis of cardiac diseases based on vortices as clinical bi-omarkers. The behavior of the restored cardiac flow fields which are filtered with the optimal kernel size and also with some values preceding and succeeding it are similar to that observed in studies with synthetic flow fields. This confirms that the optimal size of the kernel is related to the cardiac vortex size as is observed in the case of synthetic flow fields.
Effects of tree species and planting forms on the thermal comfort of campsites in hot and humid areas of China
Authors: Luo Xinyi , Zhao Yang , Yang Jiahao , Guo Tongye , Li Yuankui 
Published: August 2023

Abstract

Camping has become a popular outdoor activity in China. However, the long and scorching summers in China's hot and humid regions pose challenges for campsites in maintaining thermal comfort. Therefore, we explored the impact of tree species and planting methods on the thermal comfort of urban campsites in hot and humid areas using the ENVI-met model to simulate the conditions of the study area. The reliability of the model was validated by comparing the simulated values of air temperature and relative humidity with field measurements. We conducted an in-depth analysis of common trees in hot and humid areas and analyzed the effects of five tree species and four tree planting forms on the microclimate of campsites in such areas, using the physiological equivalent temperature (PET) as the evaluation index of thermal comfort. The results indicated that: (1) trees with a low LAI and large crown had a stronger ability to improve outdoor thermal comfort than trees with a high LAI and small crown, and (2) among the four common tree planting forms in campsites, the patches form exhibited the strongest microclimate regulation capacity, leading to a more effective improvement in outdoor thermal comfort compared to that of the single tree, U-shaped, and surrounding planting forms. This study provides a reference for the planting design of outdoor campsites in hot and humid regions of China.
The Application of Graph Neural Network Based on Multi-Head Attention Optimization in Information Recommendation Systems
Authors: Li Yibing 
Published: August 2023

Abstract

This study proposes a group information recommendation (GIR) model to accurately and comprehensively explore group preferences and enhances complex groups' recommendation effect. Firstly, the group recommendation (GR) algorithm, Multi-Head Attention (MHA) mechanism, and Graph Neural Network (GNN) are summarized. Secondly, the GIR model is constructed using the MHA and GNN models. On the one hand, the model considers the importance of differences in group objects' preferences in different item recommendations. On the other hand, the impact of the interaction between objects on group preference modeling is considered. The constructed GIR model includes an embedding layer, a propagation layer, a fusion layer, and a prediction layer. Finally, experiments are conducted to verify the effectiveness of the constructed model. The verification results reveal that: (1) compared with other recommendation models, the Multi-Head Attention-Graph Neural Network (MHA-GNN) model is improved by 1.05% in the Mean Reciprocal Rank (MRR) index. (2) The recommendation precision and MRR value of the MHA-GNN model are higher than those of other fused models. (3) Compared with other recommendation models, the MHA-GNN model has the highest recommendation precision and better recommendation effect. The above conclusions show that the introduced GNN technology can effectively improve the performance of the GR model. At the same time, the established GIR system has a more accurate recommendation effect, which can realize the efficient mining of group preferences. This study aims to achieve the efficient recommendation of information and save information retrieval time.
Intratracheal budesonide mixed with surfactant to increase survival free of bronchopulmonary dysplasia in extremely preterm infants: statistical analysis plan for the international, multicenter, randomized PLUSS trial
Authors: Francis Kate L , McKinlay Christopher J , Davis Peter G , Donath Susan M , Manley Brett James 
Published: August 2023

Abstract
The PLUSS trial is a multicenter, two-arm, parallel, double-blind, randomized controlled trial, enrolling at least 1060 extremely preterm infants in 21 participating hospitals across four countries (Australia, New Zealand, Canada and Singapore). Enrolment commenced in January 2018 and was completed in March 2023. The trial is investigating whether intratracheal budesonide (a corticosteroid) combined with surfactant, compared to surfactant alone, will increase survival free of bronchopulmonary dysplasia (BPD) in extremely preterm infants.