bluuebunny/crossref_metadata_2025_split huggingface dataset:
Biosynthesis and characterization of silver nanoparticles from Punica granatum (pomegranate) peel waste and its application to inhibit foodborne pathogens
Authors: Farouk Salma M. , Abd-Elhalim Basma T. , Mohamed Reham M. , Arabe Naira M. , Hussain Ahmed A. T. , Mostafa Mostafa E. , Hemdan Bahaa , Sedeek Salwa M. , Bakry Ashraf , Ebeed Naglaa , Elhariry Hesham , Galal Ahmed , Abu-Hussien Samah H. 
Published: July 2023

Abstract
Despite their role in controlling pathogens, the misuse of antibiotics leads to the antibiotic resistance phenomenon. The biosynthesis process of silver nanoparticles from plant extracts has earned wide regard worldwide because of its eco-friendly characteristics. The current study aims to biosynthesize and characterize silver nanoparticles from pomegranate peel waste PPW-AgNPs as well as test their antimicrobial potentials against foodborne pathogens. Ultraviolet (UV) spectrum, X-ray diffraction analysis (XRD), Zeta potential, Fourier transform infrared (FTIR) and scanning electron microscopy (SEM) analysis were used to characterize the produced PPW-AgNPs. The colour change from yellow to brown, the detection of a peak in a UV spectrum at 440 nm of 0.9 SPR, and four intense peaks in XRD and SEM analysis revealed the existence of spherical particles of PPW-AgNPs. Zeta potential was − 0.03 revealing the negative charge of PPW-AgNPs. Eight foodborne pathogenic strains (6 bacteria and 2 fungal strains) Bacillus subtilis ATCC 6633, Enterococcus faecalis ATCC 29212, Escherichia coli ATCC 8379, Klebsiella pneumoniae ATCC 00607, Salmonella typhi DSM 17058, Shigella sonnei DSM 5570, Aspergillus flavus ATCC 9643, and Rhizopus oryzae ATCC 96382 were used to test the inhibitory potential of PPW-AgNPs. All silver nanoparticles exhibited high antimicrobial activity against all tested strains. The most sensitive strain was B. subtilis while the highest resistant one was R. oryzae with IZD of 4.5 and 0.96cm. Pomegranate peel waste plays a key role in the simple, eco-friendly green synthesis of extracellular stable AgNPs as an alternative source for harmful chemical disinfectants.
A Comparative Study between Kähler and Non-Kähler Hyperbolicity
Authors: Marouani Samir 
Published: July 2023

Abstract
In this note, we establish a connection between SKT and balanced hyperbolicity, highlighting their relationship with Kähler hyperbolicity in the sense of Gromov.
MSC code: 2020: 32Q45, 53C55, 14F25, 14F40, 53C30.
The patient's subjective experiences should make person-centred care visible in stem cell transplantation care - a qualitative study
Authors: SVANBERG Anncarin , WALLIN Alexandra 
Published: July 2023

Abstract
Purpose
To describe patients’ subjective experiences, reported in a study specific questionnaire with open-ended questions, when being treated and cared for during autologous hematopoietic stem cell transplantation and to further discuss the importance of person-centred care in a clinical context.
The hematopoietic stem cell transplant affected the patients' physical, mental, and spiritual well-being. Taking patients' needs into account can improve the care experience and alleviate the impact of difficulties during the transplant period. According to the Swedish Patient Act (2014: 821), patients have the right to be involved in their care
Methods
Sixty-four patients were asked to participate in the study and chose to take part. Fifty-two patients fulfilled the study specific questionnaire (81%). A thematic analysis, was performed with the support of Braun and Clarke, including both inductive and semantic approaches. This is secondary data, part of a larger project evaluating patient experience of safety and security in care during autologous hematopoietic stem cell transplantation regardless of inpatient or outpatient care. The study has a qualitative, pragmatic, comparative design.
Results
Three themes emerged from the analysed data: subjectively perceived positive information and support; subjectively perceived negative information and support; subjective desired increased possibility of person-centred care.
Conclusions
The results of the upcoming study can design new functional tools to support person-centred care in the care of patients undergoing hematopoietic stem cell transplantation or cared for in the haematology department. The results revealed, despite unequally distributed groups, similar subjective experiences of care.
Enhanced immune ageing associated with increasing COVID-19 disease severity
Authors: Lord Janet , Veenith Tonny , Sullivan Jack , Oates Archana , Richter Alex , Greening Neil , McAuley Hamish , Evans Rachael , Moss Paul , Moore Shoona , Turtle Lance , Gautam Nandan , Gilani Ahmed , Bajaj Manan , Wain Louise , Brightling Christopher , Raman Betty , Marks Michael , Singapuri Amisha , Elneima Omer , Openshaw Peter , Duggal Niharika A 
Published: July 2023

Abstract
Background
The striking increase in COVID-19 severity in older adults provides a clear example of immunesenescence, the age-related remodelling of the immune system. To better characterise the association between convalescent immunesenescence and acute disease severity, we determined the immune phenotype of COVID-19 survivors and non-infected controls.
Results
We performed detailed immune phenotyping of peripheral blood mononuclear cells isolated from 103 COVID-19 survivors 3–5 months post recovery who were classified as having had severe (n = 56; age 53.12 ± 11.30 years), moderate (n = 32; age 52.28 ± 11.43 years) or mild (n = 15; age 49.67 ± 7.30 years) disease and compared with age and sex-matched healthy adults (n = 59; age 50.49 ± 10.68 years). We assessed a broad range of immune cell phenotypes to generate a composite score, IMM-AGE, to determine the degree of immune senescence. We found increased immunesenescence features in severe COVID-19 survivors compared to controls including: a reduced frequency and number of naïve CD4 and CD8 T cells (p < 0.0001); increased frequency of EMRA CD4 (p < 0.003) and CD8 T cells (p < 0.001); a higher frequency (p < 0.0001) and absolute numbers (p < 0.001) of CD28− ve CD57+ ve senescent CD4 and CD8 T cells; higher frequency (p < 0.003) and absolute numbers (p < 0.02) of PD-1 expressing exhausted CD8 T cells; a two-fold increase in Th17 polarisation (p < 0.0001); higher frequency of memory B cells (p < 0.001) and increased frequency (p < 0.0001) and numbers (p < 0.001) of CD57+ ve senescent NK cells. As a result, the IMM-AGE score was significantly higher in severe COVID-19 survivors than in controls (p < 0.001). Few differences were seen for those with moderate disease and none for mild disease. Regression analysis revealed the only pre-existing variable influencing the IMM-AGE score was South Asian ethnicity (\(\beta\) = 0.174, p= 0.043), with a major influence being disease severity (\(\beta\) = 0.188, p = 0.01).
Conclusions
Our analyses reveal a state of enhanced immune ageing in survivors of severe COVID-19 and suggest this could be related to SARS-Cov-2 infection. Our data support the rationale for trials of anti-immune ageing interventions for improving clinical outcomes in these patients with severe disease.
Multiple time-scale analysis of information representation for diverse learning rules among neurons
Authors: Noyama Hiroki , Iguchi Ryuki , Tanaka Mai , Li Bin , Kotani Kiyoshi , Jimbo Yasuhiko 
Published: July 2023

Abstract
Neural networks are complex systems in which multiple time-scale variables interact with each other, and how synaptic plasticity represents information related to firing activity is poorly understood. In this study, we constructed a synaptic plasticity model that considers physiological constraints by incorporating the strength of synaptic connections, dependent on the spike-timing-dependent plasticity (STDP) rule, into the voltage dependent theta neuron model. Next, we analyzed the multiple time-scale behaviors of the pulse-coupled oscillator system constructed using the synaptic plasticity model. The results show that the two-body system, which interacts by the product of conductance and potential difference, converges to the equilibrium point without chaotic solutions, that various coupling states are possible depending on the combination of learning rule and reversal potential values, that the number of clusters in the multi-body system can be predicted from the analysis results for the two-body system and that the final convergence point and vector field changed little for either excitatory or inhibitory neurons when the external current \(I\) was set to around the value at which the neuron spontaneously fires.
Traffic Flow Prediction on Graph with Node-level Curriculum Scheduler
Authors: Zhang Zhiwen , Wang Hongjun , Fan Zipei , Song Xuan , Shibasaki Ryosuke 
Published: July 2023

Abstract
Traffic flow prediction is a critical part of the intelligent transportation system , and many schemes have been proposed for accurate flow prediction based on traffic sensors. However, existing approaches mainly capture spatial-temporal (ST) dependencies from the traffic graph and train their models using randomly ordered data. This approach ignores the fact that the modeling difficulty of each sensor/node from the traffic graph can vary significantly due to its spatial dependencies and temporal trends, leading to unreliable and unstable predictions for each traffic sensor in real-world applications. These issues motivated us to design a more effective training process for sensors with different levels of difficulty. The ST modeling difficulty stems from two factors: (I) deviations between the normal component and abnormal component in the time sequences; and (II) deviations between the learned relation and the explicit relation of a predetermined graph in the spatial dependencies. In this case, we argue that a well-designed curriculum with an easy-to-difficult order can benefit the training of ST models. This approach draws inspiration from the human learning principle that models should first learn straightforward concepts before tackling more difficult ones. To implement this approach, this paper proposes a method to measure the ST difficulty at the node level of traffic graphs from both spatial and temporal aspects. Then, it conducts a curriculum during the ST model training procedure. Specifically, 1 based on the ST difficulty score, the model training starts from a subgraph whose nodes are considered ”easy” because of their relatively consistent spatial relationships and regular temporal patterns. After that, more difficult nodes are gradually added to the subgraph and participate in the following training stages. We have conducted extensive experiments on two public traffic datasets, which show the superiority of our proposed curriculum scheduler over multiple state-of-the-art ST models.
Preoperative Controlling Nutritional Status(CONUT) as an optimal prognostic nutritional index to predict the long-term outcome after radical surgery for colorectal cancer
Authors: Liu Lixiang , Miao Ji , Gao Bo , Yuan Qinggang , Zhou Shizhen , Xu Tingting , Ding Chao , Guan wenxian 
Published: July 2023

Abstract
Background
Controlled nutritional status (CONUT) can effectively reflect the nutritional status of the body, which is closely related to cancer prognosis. The purpose of this study was to investigate the relationship between the CONUT score and prognosis after radical surgery for colorectal cancer, and to compare the predictive ability of the CONUT score with other indexes.
Methods
A retrospective analysis included 217 patients with newly diagnosed colorectal cancer was performed. The CONUT score was calculated based on the serum albumin level, total lymphocyte count, and total cholesterol level. The cutoff value of the CONUT score for predicting prognosis was 4 according to the Youden Index by Receiver operating characteristic curve. The associations between the CONUT score and the prognosis were performed by Kaplan-Meier curves and Cox regression analysis.
Results
Stratified by the cutoff value of the CONUT score, patients were divided into CONUT LOW group(n = 189) and CONUT HIGH group (n = 28). CONUT HIGH group had worse overall survival(p = 0.013) and Replase-free survival(P = 0.015). The predictive performances of CONUT were superior to NLR, mGPS and PNI. Meanwhile, the predictive performances of CONUT + TNM stage for 3-year OS (AUC = 0.803) and 3-year RFS (AUC = 0.765) were no less than SMI + TNM stage. The CONUT score was negatively correlated with SMI(p<0.01).
Conclusions
The CONUT score as a nutritional indicator could predict long-term outcome after radical surgery for colorectal cancer, and its predictive ability was superior to other indexes. The correlation between the CONUT score and skeletal muscle may be one of the factors that play a predictive role.
The triangular area between the Greater, Lesser, and Third Occipital Nerves and its possible clinical significance
Authors: Sağlam Latif , Gayretli Özcan , Coşkun Osman , Kale Ayşin 
Published: July 2023

Abstract
Purpose: Occipital Neuralgia (ON) is defined as a unilateral or bilateral pain in the posterior area of the scalp occurring in the distribution area or areas of the greater occipital nerve (GON), lesser occipital nerve (LON), and/or third occipital nerve (TON). In the present study, the purpose was to show the possible importance of the triangular area (TA) in nerve block applied in ON by measuring the TA between GON, TON, and LON.
Methods: A total of 24 cadavers (14 male, 10 female) were used in the present study. The suboccipital region was dissected, revealing the points where the GON and TON pierced the trapezius muscle and superficial area, and the point where the LON left the sternocleidomastoid muscle from its posterior edge and was photographed. The area of the triangle between the superficial points of these three nerves and the center of gravity of the triangle (CGT) were determined by using the Image J Software and the results were analyzed statistically.
Results: The mean TA values were 952.82 ± 313.36 mm2 and 667.55 ± 273.82 mm2, respectively in male and female cadavers. Although no statistically significant differences were detected between the sides (p> 0.05), a statistically significant difference was detected between the genders (p< 0.05). The mean CGT value was located approximately 5 cm below and 3-3.5 cm laterally from the external occipital protuberance in both genders and sides.
Conclusion: In ON that has more than one occipital nerve involvement, all occipital nerves can be blocked by targeting TA with a single occipital nerve block, and thus, the side effects that may arise from additional blocks can be reduced. The fact that there was a statistically significant difference according to the genders in the TA suggests that different block amounts can be applied according to gender.
Second ejaculation produces good quality sperm and decreases the rate of unexpected ICSI cycle
Authors: Zhang Xiaohui , Wang Shikai , Huang Yueyue , Mao Xianbao , Li Zhengda , Wei Pingpin , Chen Liangshi , Li Dawen , Xue Lintao 
Published: July 2023

AbstractBackground:Second ejaculation can influence sperm quality which may define the first line treatment. The purpose of this study was to evaluate the effectiveness of a second ejaculation in decreasing the intracytoplasmic sperm injection (ICSI) rate in unexpected ICSI cycle.Methods:A retrospective study of unexpected ICSI cycle and conventional in vitro fertilization IVF was conducted. The unexpected ICSI group was subdivided into the second ejaculation IVF and ICSI groups based on second ejaculation semen parameters after swim-up. To predict the influence of sperm protein between two ejaculation semen, the PXD010695 dataset and differentially expressed proteins (DEPs) were downloaded and subjected to bioinformatics analysis.Results:Semen volume and sperm DNA fragmentation (SDF) were lower, whereas sperm concentration, total sperm count, progressive motility and total progressive motility sperm count after swim-up were higher during the second ejaculation. A lower rate of fertilization, a higher rate of good-quality embryos on day 3 and good-quality blastocyst were found in the second ejaculation IVF group. There was no significant difference among the groups in rate of rescue ICSI, oocytes utilization rate, clinical pregnancy, implantation, miscarriage, and live birth. Bioinformatics analysis indicated that the second ejaculation with downregulated proteins is related to a reduction in motility and forms a protein module with glutathione metabolism.Conclusion:For unexpected ICSI group, second ejaculation IVF produced good quality sperm and could be an economical and secure alternative to decrease the rate of unexpected ICSI.
Influence of nanosilica on properties of NR/EPDM composites
Authors: S Pradeep Kumar , G Prabhakaran , S Vishvanathperumal 
Published: July 2023

Abstract
In this study, the impacts of nanosilica on the properties of natural rubber and ethylene-propylene-diene rubber blends (NR/EPDM; 70/30 phr/phr) were examined. Utilising the melt compounding method, the composites were developed. The effects of thioctic acid (TA) on the surface modification of silica (SiO2) are compared to those of bis(3-triethoxysilylpropyl)tetrasulfide (TESPT)/polyoxyethylene (20) sorbitan monolaurate (TWEEN-20) on the curing, mechanical, tensile and compression set, and swelling properties of nanocomposites in this study. In NR/EPDM composites, the nanosilica made from rice husk ash was employed as reinforcing nanofiller. For the production of rubber composites, the interaction at the interface between the nanosilica and the NR/EPDM matrix is essential. The 2:1 ratio between TESPT and TWEEN-20 is maintained in this study's utilisation of TESPT and TWEEN-20 as a silica modifier. It has been found that the attributes of NR/EPDM blends are mostly influenced by the presence of TA modified nanosilica. When compared to pure NR/EPDM blends, the incorporation of TA modified nanosilica considerably increased tensile and tear strength by up to 76% and 48%, respectively. Swell measurement, abrasion resistance, and FESEM all provided additional evidence in support of these conclusions.
Nursing students' perceived parental child-rearing attitudes and ego identity and their relationship with college adjustment: Research Article
Authors: Choi Hye Seon , Lee Sona , Seo Eunju 
Published: July 2023

Abstract
Background: This exploratory investigation aimed to determine whether nursing students' perceived parental child-rearing attitude and ego identity were associated with college adjustment.
Methods:This study surveyed 224 nursing students enrolled in universities located in two regions within South Korea. Collected data were subjected to correlation analysis using SPSS version 26.0 for Windows.
Results:Among the parental child-rearing attitudes, paternal emotional warmth (r =.30, p <.001), maternal emotional warmth (r =.38, p <.001), and ego identity (r = 0.71, p <.001) were positively associated with nursing students' college adjustment, whereas maternal rejection was negatively correlated with ego identity (r = −.28, p <.001) and college adjustment (r = −.15, p =.025).
Conclusions:To improve nursing students' college adjustment, universities should establish programs that promote ego identity, provide education on parental child-rearing attitudes for underclassmen and parents, and improve parent–child relationship.
Optimization of regeneration conditions using response surface methodology for embryogenic cell-derived protoplasts in Angelica gigas Nakai
Authors: Lee Han-Sol , Han Jong-Eun , Bae Eun-Kyung , Jie Eun Yee , Kim Suk-Weon , Kwon Hyuk Joon , Lee Gun-Myung , Lee Hak Sung , Park So-Young 
Published: July 2023

Abstract
Background
To achieve a stable protoplast regeneration system, various factors must be considered in combination. In this study, the culture conditions at each developmental stage of protoplasts isolated from embryogenic calli of Angelica gigas Nakai to their regeneration into plants were optimized using response surface methodology (RSM).
Results
To establish an efficient culture method, the plating efficiencies of liquid, sieve, and thin-alginate-layer (TAL) methods were investigated. The RSM was designed using three independent factors: 2,4-D, kinetin, and phytosulfokine (PSK). Optimized values ​​were predicted in the cell division, multi-cell formation, and somatic embryo (SE) stages to determine which developmental stage is favorable for regeneration. Among the culture methods tested, TAL showed the highest multi-cell formation efficiency. During the optimization of each step from protoplasts to plant regeneration, the concentrations of 2,4-D and kinetin gradually increased throughout the culture process, and a relatively high concentration of 90 nM PSK was required for multi-cell formation. Using RSM, the highest SE development was predicted to occur when 1.5 mg·L− 1 2,4-D, 1.0 mg·L− 1 kinetin, and 0 nM PSK are used, which was approximately 3.64-fold higher than those of the control. In the experiments confirming reproducibility using the conditions identified with RSM, the same trend was observed.
Conclusions
This study indicates that (1) different concentrations of key factors are required for each developmental stage during protoplast culture and that (2) RSM can be used to reliably optimize their required concentrations.
Mathematical Modelling of The Pneumonia Dynamics with a Carrier Among a Children Under Age Five: The Case of Bule Hora Town, Oromia Region, Ethiopia
Authors: Jilo J. , Daba Mitiku , E. Abdulsamad 
Published: July 2023

Abstract
Pneumonia has been a major airborne transmitted disease and continues to pose a major public health problem in both developed and developing countries of the world. In this study, we constructed and analyzed a non-linear deterministic mathematical model in case of Bule Hora town for assessing the community-level impacts of natural immunity, other protection measures and treatment on the transmission dynamics of pneumonia disease in a population of varying size. Our model exhibits two kinds of equilibrium points: pneumonia disease-free equilibrium point, and pneumonia endemic equilibrium point. Thus, for pneumonia infection, the necessity of the pneumonia reproduction number R 0 < 1, although essential, it might not be enough to completely eradicate the pneumonia infection from the considered community. Our examination of sensitivity analysis shows that the pneumonia infection transmission rate plays a crucial role to change the qualitative behavior of dynamics of pneumonia infection. By taking standard data from Bule hora teaching Hospital and published literature, our numerical computations show that the numerical value of pneumonia infection model reproduction number greater than one it implies that the disease spreads throughout the community. Finally, our numerical simulations show that natural immunity and treatment against pneumonia disease have effectively decreasing pneumonia expansion.
Solvothermal synthesis of cobalt PCP pincer complexes from [Co2(CO)8]
Authors: Schratzberger Heiko , Himmelbauer Daniel , Eder Wolfgang , Weiser Michael , Stöger Berthold , Kirchner Karl Anton 
Published: July 2023

Abstract
Treatment of [Co2(CO)8 ] with the ipso-substituted P(C-X)PY ligands (X = Br, Cl; R = iPr, tBu) bearing Y = NH and CH2linkers under solvothermal conditions affords the five-coordinate Co(I) and Co(III) complexes [CoI(PCPY-R)(CO)2] and [CoIII(PCPY-R)X2]. The later are paramagnetic exhibiting a solution magnetic moment in the range of 3.0 to 3.3µB which is consistent with a d6 intermediate spin system corresponding to two unpaired electrons. In the case of P(C-X)PY ligands (X = Br, Cl; R = tBu; Y = NH) the formation of the square planar Co(II) complex [Co(PCPNH-tBu)X] was favored. This complex gives rise to a magnetic moment of 1.8 µB being consistent with a d7 low spin system corresponding to one unpaired electron. All complexes are characterized by means of spectroscopic techniques (NMR, IR), HR-MS. Representative complexes were also characterized by X-ray crystallography.