bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stiff Substrate Induces Nucleus Pulposus Cell Ferroptosis via YAP and N‐Cadherin Mediated Mechanotransduction
Authors: Ke Wencan , Liao Zhiwei , Liang Huaizhen , Tong Bide , Song Yu , Li Gaocai , Ma Liang , Wang Kun , Feng Xiaobo , Li Shuai , Hua Wenbin , Wang Bingjin , Yang Cao 
Published: April 2023

AbstractIncreased tissue stiffness is associated with various pathological processes, such as fibrosis, inflammation, and aging. The matrix stiffness of the nucleus pulposus (NP) tissues increases gradually during intervertebral disc degeneration (IDD), while the mechanism through which NP cells sense and react to matrix stiffness remains unclear. In this study, the results indicate that ferroptosis is involved in stiff substrate‐induced NP cell death. The expression of acyl‐CoA synthetase long‐chain family member 4 (ACSL4) increases in NP cells of the stiff group, which mediates lipid peroxidation and ferroptosis in NP cells. In addition, stiff substrate activates the hippo signaling cascade and induces the nuclear translocation of yes‐associated protein (YAP). Interestingly, inhibition of YAP is efficient to reverse the increase of ACSL4 expression caused by matrix stiffness. Furthermore, stiff substrate suppresses the expression of N‐cadherin in NP cells. N‐cadherin overexpression can inhibit YAP nuclear translocation via the formation of the N‐cadherin/β‐catenin/YAP complex, and reverse matrix stiffness‐induced ferroptosis in NP cells. Finally, the effects of YAP inhibition and N‐cadherin overexpression on IDD progression are further illustrated in animal models. These findings reveal a new mechanism of mechanotransduction in NP cells, providing novel insights into the development of therapies for the treatment of IDD.
Halides‐Enhanced Buried Interfaces for Stable and Extremely Low‐Voltage‐Deficit Perovskite Solar Cells
Authors: Deng Jidong , Wei Kun , Yang Li , Lin Lu , Xiao Yuanhui , Cai Xuanyi , Zhang Cuiping , Wu Deyin , Zhang Xiaoli , Zhang Jinbao 
Published: April 2023

AbstractThe perovskite buried interfaces have demonstrated pivotal roles in determining both the efficiency and stability of perovskite solar cells (PSCs); however, challenges remain in understanding and managing the interfaces due to their non‐exposed feature. Here, we proposed a versatile strategy of pre‐grafted halides to strengthen the SnO2–perovskite buried interface by precisely manipulating perovskite defects and carrier dynamics through alteration of halide electronegativity (χ), thereby resulting in both favorable perovskite crystallization and minimized interfacial carrier losses. Specifically, the implementation of fluoride with the highest χ induces the strongest binding affinity to uncoordinated SnO2 defects and perovskite cations, leading to retarded perovskite crystallization and high‐quality perovskite films with reduced residual stress. These improved properties enable champion efficiencies of 24.2% (the control: 20.5%) and 22.1% (the control: 18.7%) in rigid and flexible devices with extremely low voltage deficit down to 386 mV, all of which are among the highest reported values for PSCs with a similar device architecture. In addition, the resulting devices exhibit marked improvements in the device longevity under various stressors of humidity (>5000 h), light (1000 h), heat (180 h), and bending test (10 000 times). This method provides an effective way to improve the quality of buried interfaces toward high‐performance PSCs.
An Overstretch Strategy to Double the Designed Elastic Stretchability of Stretchable Electronics
Authors: Li Juyao , Wu Xiaolei , Su Yewang 
Published: April 2023

AbstractAchieving or enhancing the elastic stretchability of inorganic stretchable electronics is critically significant. However, only two types of fundamental strategies—using the prestrained elastic substrate and designing the geometric layouts—are exploited thus far. This study proposes a third strategy, an overstretch strategy, applied beyond the designed elastic range of stretchable structures after transfer printing and bonding to a soft substrate. The theoretical, numerical, and experimental results collectively prove that the overstretch strategy can double the designed elastic stretchability of fabricated stretchable electronics and is valid for various geometrical interconnects with both thick and thin cross‐sections. The underlying mechanism is that the elastic range of the critical part of the stretchable structure is doubled, owing to the evolution of the elastoplastic constitutive relation during overstretching. The overstretch strategy can be easily executed and combined with the other two strategies to enhance elastic stretchability, which has profound implications for the design, fabrication, and applications of inorganic stretchable electronics.
Mechanochemical Synthesis of High‐Entropy Perovskite toward Highly Sensitive and Stable X‐ray Flat‐Panel Detectors
Authors: Wu Haodi , Chen Xu , Song Zihao , Zhang Ao , Du Xinyuan , He Xin , Wang Hanqi , Xu Ling , Zheng Zhiping , Niu Guangda , Tang Jiang 
Published: April 2023

AbstractPerovskites are attracting attention for optoelectronic devices. Despite their promise, the large‐scale synthesis of perovskite materials with exact stoichiometry, especially high‐entropy perovskites, has been a major challenge. Moreover, the difficulty in stoichiometry control also hinders the development of perovskite X‐ray flat‐panel detectors. Previous reports all employed simple MAPbI3 as the active layer, while the performance still falls short of optimized single‐crystal‐based single‐pixel detectors. Herein, a scalable and universal strategy of a mechanochemical method is adopted to synthesize stoichiometric high‐entropy perovskite powders with high quality and high quantity (>1 kg per batch). By utilizing these stoichiometric perovskites, the first FA0.9MA0.05Cs0.05Pb(I0.9Br0.1)3‐based X‐ray flat‐panel detector with low trap density and large mobility–lifetime product (7.5 × 10−3 cm2 V−1) is reported. The assembled panel detector exhibits close‐to‐single‐crystal performance (high sensitivity of 2.1 × 104 µC Gyair−1 cm−2 and ultralow detection limit of 1.25 nGyair s−1), high spatial resolution of 0.46 lp/pixel, as well as excellent thermal robustness under industrial standards. The high performance in the high‐entropy perovskite‐based X‐ray FPDs has the potential to facilitate the development of new‐generation X‐ray‐detection systems.
Solar Biomass Reforming and Hydrogen Production with Earth‐Abundant Si‐Based Photocatalysts
Authors: Choi Yuri , Choi Sungho , Lee Inhui , Nguyen Trang Vu Thien , Bae Sanghyun , Kim Yong Hwan , Ryu Jaegeon , Park Soojin , Ryu Jungki 
Published: April 2023

AbstractEfficient electrochemical hydrogen production and biomass refinery are crucial for the decarbonization of various sectors. However, their energy‐intensive nature and low efficiency have hindered their practical application. In this study, earth‐abundant and non‐toxic photocatalysts that can produce hydrogen and reform biomass efficiently, utilizing unlimited solar energy, are presented. The approach involves using low‐bandgap Si flakes (SiF) for efficient light‐harvesting, followed by modification with Ni‐coordinated N‐doped graphene quantum dots (Ni‐NGQDs) to enable efficient and stable light‐driven biomass reforming and hydrogen production. When using kraft lignin as a model biomass, SiF/Ni‐NQGDs facilitate record‐high hydrogen productivity at 14.2 mmol gcat−1 h−1 and vanillin yield of 147.1 mg glignin−1 under simulated sunlight without any buffering agent and sacrificial electron donors. SiF/Ni‐NQGDs can be readily recycled without any noticeable performance degradation owing to the prevention of deactivation of Si via oxidation. This strategy provides valuable insights into the efficient utilization of solar energy and practical applications of electro‐synthesis and biomass refinement.
Tunable Broadband Acoustic Vortex Generator with Multiple Orders Based on Mie Resonances Structure
Authors: Liu Chunxia , Ye Yingrui , Wu Jiu Hui 
Published: April 2023

AbstractAcoustic vortices are intensely researched in metasurfaces for their potential application in acoustic communication and particle manipulation. By elaborately designing acoustic metasurfaces with phase profiles, an acoustic vortex is obtained. However, most existing studies are limited to the single working frequency and the specific topological charge. To address these limitations, a tunable broadband acoustic vortex generator is designed to generate acoustic vortices with multiple orders. For this purpose, an annulus subwavelength Mie resonator is theoretically proposed first. In the Mie resonator, the multipole mode is excited by coupling eccentric monopole sources at related resonance frequencies. Then coupling the Mie resonance structure and two eccentric monopole sources can realize the multipole crossing, thus generating acoustic vortices with topological charge m of ±1, ±2, ±3, ±4, and ±5. Numerical simulations and an experiment further confirm the theory. In addition, frequency tunability, broadband characteristics, and system robustness are quantitatively studied. The designed vortex generator performs well on these characteristics, which may have potential applications in acoustic communication for multiplexing and demultiplexing.
Stretchable Ultraviolet Curable Ionic Conductive Elastomers for Digital Light Processing Based 3D Printing
Authors: He Xiangnan , Cheng Jianxiang , Li Zhenqing , Ye Haitao , Sun Zechu , Liu Qingjiang , Li Honggeng , Wang Rong , Ge Qi 
Published: April 2023

AbstractHighly stretchable and transparent ionic conducting materials enable electronic devices to have a distinguishable working mechanism and performances from the conventional electronics. Compared with hydrogels which contain large amounts of water to dissolve ions, ionic conductive elastomers (ICEs) are solvent‐free, and intrinsically immune from dehydration. However, the current manufacturing technologies constrain the ICE‐based ionotronics to simple and bulk geometries with single material, which greatly limits functionality and performance of ICEs‐based ionotronics. Herein, a stretchable ultraviolet curable ICEs (SUV‐ICEs) for 3D printing approach to fabricate complex 3D flexible electronics is reported. The developed SUV‐ICEs are highly stretchable and thermally stable. Using a self‐built DLP‐based 3D printer, that is able to print 3D flexible electronics consisting of SUV‐ICE covalently bonded with other dielectric elastomer, such as SUV‐ICE strain sensors, and a flexible mini‐keyboard.
Spin‐Selective Absorption and Geometric‐Phase Modulation via Chiral Metasurface in Triple Bands
Authors: Chen Wen Qiong , Gou Yue , Zhang Jing Wei , Niu Tiao Ming , Ma Qian , Ma Hui Feng , Mei Zhong Lei , Cui Tie Jun 
Published: April 2023

AbstractMetasurfaces with spin‐selective reflection or transmission functions for circularly‐polarized (CP) incident waves have aroused researchers' great attention. However, current spin‐selective metasurface designs have yet to mature into a practical method due to the limitations of single operating band or inefficient phase modulation. Herein, a novel chiral meta‐atom is proposed, exhibiting spin‐selective absorption/reflection functions for dual‐orthogonal CP incident waves at three different operating bands. More significantly, the Pancharatnam–Berry phase theory is introduced at all working frequencies to generate a full 2π reflection phase modulation by rotating the chiral resonator, and the three distinct absorption bands remain almost constant with the rotation. Theoretical results indicate that high absorption can separately act on left‐handed or right‐handed CP incident waves at triple bands, and meanwhile, the other incident wave with different handedness is efficiently reflected without changing the handedness. As a proof of concept, two tri‐band meta‐devices with spin‐selective anomalous reflection and spin‐selective orbital angular momentum generating functions are designed and experimentally characterized, both of which exhibit excellent spin‐dependent bi‐functional performances at three different operating bands. The research results provide a promising route to realize spin‐selective meta‐devices with multi‐band operating modes in wireless communication systems and multispectral imaging and information encryption fields.
Microstructure Engineered Photon‐Managing Films for Solar Energy to Biomass Conversion
Authors: Shen Lihua , Lou Runnan , Aili Ablimit , Huggins Curtis James , Yin Xiaobo 
Published: April 2023

AbstractConversion of solar energy into chemical energy through natural photosynthesis plays a crucial role in sustainable energy transformation, bioresource production, and CO2 biofixation. Nevertheless, the overall solar energy to chemical energy (biomass) conversion efficiency in the photosynthetic organisms is still unsatisfactory because of their inefficient utilization of solar light. Here, a photonic method to improve photosynthesis of a unicellular green microalga, Chlamydomonas reinhardtii, a photosynthetic organism model is reported. For this purpose, an easy‐to‐fabricate microphotonic film is developed to improve the spectral quality of solar light reaching the microalgae through photon management (i.e., simultaneous solar spectral conversion and directional fluorescent emission). This study demonstrates that the short‐term oxygen evolution rate and the long‐duration biomass production of microalgae in 200‐mL laboratory photobioreactors are enhanced by a factor of 38% and 54%, respectively. In 5000‐mL scaled‐up bubble column photobioreactors placed outdoor under natural sunlight and weather conditions, the biomass yield is improved by more than 20% when compared to the control experiments conducted in parallel in an optically clear bubble column photobioreactor. Based on such experimental observations, the work here demonstrates the potential of photon management for promoting the solar energy‐to‐biomass conversion process of microalgae and other photosynthetic organisms.
Oligomeric Acceptor Enables High‐Performance and Robust All‐Polymer Solar Cells with 17.4% Efficiency
Authors: Li Zhixiang , Zhang Zhe , Chen Hongbin , Zhang Yunxin , Yi Yuan‐Qiu‐Qiang , Liang Ziqi , Zhao Bin , Li Miaomiao , Li Chenxi , Yao Zhaoyang , Wan Xiangjian , Kan Bin , Chen Yongsheng 
Published: April 2023

AbstractDeveloping efficient and stable all‐polymer solar cells (all‐PSCs) has received increasing attention because of their mechanical robustness for flexible devices. Based on the CH‐series small molecule acceptors, a new polymer acceptor (PZC24) is reported and obtains a decent power conversion efficiency (PCE) of 16.82% when blended with PM6. To further improve the performance, an oligomeric acceptor (CH‐D1), which possesses the same backbone structure as PZC24, is proposed and synthesized as the third component for all‐PSC system. The creative strategy improves the crystallinity and molecular packing, and can maintain the efficient charge transport channels of the all‐PSCs binary system. Therefore, the PM6:PZC24:CH‐D1 based ternary devices exhibit an impressive PCE of 17.40%, among the highest value of all‐PSCs. Compared to the PM6:PZC24, the ternary device exhibits enhanced photosoaking stability and thermal stability, simultaneously. In addition, the introduction of oligomeric acceptor does not weaken the mechanical robustness of all‐PSCs. As such, the ternary flexible devices display an excellent PCE of 15.35%. Importantly, this strategy shows excellent universality in PM6:PY‐IT and PM6:PY‐V‐γ all‐PSCs with improved PCEs over 17%. The results provide a feasible strategy to simultaneously improve photovoltaic efficiency and stability of all‐PSCs devices and herald a bright future for all‐PSCs.
Highly Efficient Electroenzymatic Cascade Reduction Reaction For The Conversion of Nitrite to Ammonia
Authors: Zhu Xuefang , Fan Xing , Lin Haiping , Li Shuni , Zhai Quanguo , Jiang Yucheng , Chen Yu 
Published: April 2023

AbstractThe electrochemical nitrite reduction reaction provides an alternative approach to offer sustainable ammonia source routes for repairing imbalances in the global nitrogen cycle. In this work, electrocatalysis is combined with enzymatic catalysis to provide an efficient and clean process for recoverable ammonia production. NO2− is reduced to NH3 by electroenzymatic cascade reduction reaction on a bioconjugate, in which 1‐butyl‐3‐methylimidazolium bromide (ILBMB) modified chloroperoxidase (CPO) is fixed on polyethyleneimine (PEI) modified multi‐walled carbon nanotubes (MWCNT) to from bioconjugate (CPO‐ILBMB/MWCNT‐PEI). 15N and 14N isotope labeling reveal that the NH3 species is derived from NO2− reduction. Density functional theory calculations identify that the FeII species in heme center of CPO serve as the key active site for NO2− reduction. The amino groups derived from MWCNT‐PEI not only serve as a bridge to covalently immobilize CPO but also enrich the NO2− ion at electrode/solution interface through electrostatic interactions. The low energy barrier of NO2− reduction and low adsorption free energy of the intermediate result in high Faradaic efficiency (96.4%), NH3 yield (112.7 mg h−1 mgCPO−1), and high selectivity in pH 5.0 solution. The highly efficient electroenzymatic reaction ensurespromising applications in the conversion of NO2− to NH3.
Alemtuzumab in relapsed immune severe aplastic anemia: Long‐term results of a phase II study
Authors: Aggarwal Nidhi , Manley Ash Lee , Shalhoub Ruba , Durrani Jibran , Rios Olga , Lotter Jennifer , Patel Bhavisha A. , Wu Colin O. , Young Neal S. , Groarke Emma M. 
Published: April 2023

AbstractImmune severe aplastic anemia (SAA) is characterized by pancytopenia and immune‐mediated bone marrow destruction. SAA may be treated with hematopoietic stem cell transplantation (HSCT) or immunosuppressive therapy (IST). However, 30% of patients treated with IST relapse. We previously reported a clinical trial of alemtuzumab in which more than half of 25 relapsed SAA patients (56%) responded hematologically. Here, we present long‐term results of a total of 42 patients. Participants with SAA who had previously completed antithymocyte globulin (ATG)‐based IST, but had relapsed, were enrolled on this study. Alemtuzumab was administered intravenously (IV) (n = 28) or subcutaneously (SC) (n = 14). The primary endpoint was hematologic response at 6 months. Secondary endpoints included relapse, clonal evolution, and survival. This trial was registered at clinicaltrials.gov (NCT00195624). Patients were enrolled over 9 years, with median follow‐up of 6 years. Median age was 32 years, with 57% being female. At 6 months, 18 patients (43%) achieved response; 15 (54%) of those who received IV compared with 3 (21%) who received SC therapy. Six patients (14%) had durable long‐term response without need for subsequent AA‐directed therapy or HSCT at last follow‐up. Nine patients had clonal evolution, with high‐risk evolution occurring in 6. Overall survival was 67% at median follow‐up of 6 years. Prolonged iatrogenic immunosuppression was observed as long as 2 years after alemtuzumab administration. Alemtuzumab induces responses in relapsed SAA, some of which are durable long‐term. However, immunosuppression can persist for years, requiring long‐term monitoring.
Cost effectiveness of non‐drug interventions that reduce nursing home admissions for people living with dementia
Authors: Jutkowitz Eric , Pizzi Laura T. , Shewmaker Peter , Alarid‐Escudero Fernando , Epstein‐Lubow Gary , Prioli Katherine M. , Gaugler Joseph E. , Gitlin Laura N. 
Published: April 2023

AbstractINTRODUCTIONSix million Americans live with Alzheimer's disease and Alzheimer's disease and related dementias (AD/ADRD), a major health‐care cost driver. We evaluated the cost effectiveness of non‐pharmacologic interventions that reduce nursing home admissions for people living with AD/ADRD.METHODSWe used a person‐level microsimulation to model the hazard ratios (HR) on nursing home admission for four evidence‐based interventions compared to usual care: Maximizing Independence at Home (MIND), NYU Caregiver (NYU); Alzheimer's and Dementia Care (ADC); and Adult Day Service Plus (ADS Plus). We evaluated societal costs, quality‐adjusted life years and incremental cost‐effectiveness ratios.RESULTSAll four interventions cost less and are more effective (i.e., cost savings) than usual care from a societal perspective. Results did not materially change in 1‐way, 2‐way, structural, and probabilistic sensitivity analyses.CONCLUSIONDementia‐care interventions that reduce nursing home admissions save societal costs compared to usual care. Policies should incentivize providers and health systems to implement non‐pharmacologic interventions.
Blended Conjugated Host and Unconjugated Dopant Polymers Towards N‐type All‐Polymer Conductors and High‐ZT Thermoelectrics
Authors: Han Jinfeng , Jiang Yufeng , Tiernan Emma , Ganley Connor , Song Yunjia , Lee Taein , Chiu Arlene , McGuiggan Patty , Adams Nicholas , Clancy Paulette , Russell Thomas P , Hopkins Patrick E. , Thon Susanna M. , Tovar John D. , Katz Howard E. 
Published: April 2023

AbstractN‐Type thermoelectrics typically consist of small molecule dopant+polymer host. Only a few polymer dopant+polymer host systems have been reported, and these have lower thermoelectric parameters. N‐type polymers with high crystallinity and order are generally used for high‐conductivity (
) organic conductors. Few n‐type polymers with only short‐range lamellar stacking for high‐conductivity materials have been reported. Here, we describe an n‐type short‐range lamellar‐stacked all‐polymer thermoelectric system with highest
of 78 S−1, power factor (PF) of 163 μW m−1 K−2, and maximum Figure of merit (ZT) of 0.53 at room temperature with a dopant/host ratio of 75 wt%. The minor effect of polymer dopant on the molecular arrangement of conjugated polymer PDPIN at high ratios, high doping capability, high Seebeck coefficient (S) absolute values relative to
, and atypical decreased thermal conductivity (
) with increased doping ratio contribute to the promising performance.
Time‐dependent Phosphorescence Color of Carbon Dots in Binary Salt Matrices through Activations by Structural Confinement and Defects for Dynamic Information Encryption
Authors: Shi Wenying , Wang Ruixing , Liu Jing , Peng Feifei , Tian Rui , Lu Chao 
Published: April 2023

AbstractThe emergence of time‐dependent phosphorescence color (TDPC) materials has taken information encryption to high‐security levels. However, due to the only path of exciton transfer, it is almost impossible to obtain TDPC for chromophores with a single emission center. Theoretically, in inorganic‐organic composites, the exciton transfer of organic chromophores depends on the inorganic structure. Here, we assign two structural effects to inorganic NaCl by metal (Mg2+ or Ca2+ or Ba2+) doping, which triggers the TDPC performance of carbon dots (CDs) with a single emission center. The resulting material is used for multi‐level dynamic phosphorescence color 3D coding to achieve information encryption. The structural confinement activates the green phosphorescence of CDs; while the structural defect activates tunneling‐related yellow phosphorescence. Such simply doped inorganic matrices can be synthesized using the periodic table of metal cations, endowing chromophores with tremendous control over TDPC properties. This demonstration extends the design view of dynamic luminescent materials.