bluuebunny/crossref_metadata_2025_split huggingface dataset:
Knowledge translation in Anglo-American paramedicine: a scoping review
Authors: Hanson Ashley , Burton Christopher 
Published: January 2025

ObjectiveTo map what is currently known about knowledge translation (KT) in Anglo-American paramedicine. The review focuses on reported barriers and facilitators to the implementation of new knowledge, and the use of models, theories and frameworks to guide implementation practice.DesignScoping review reported as per both the Joanna Briggs Institute and Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews reporting guidelines.Data sourcesCINAHL (EBSCO Host) and Medline (OVID interface) were searched from January 2000 to May 2023. Reference lists of all included papers were reviewed, and several key professional journals were hand-searched.Eligibility criteria for selecting studiesPrimary sources that focused on KT models, theories or frameworks, or barriers and facilitators to KT implementation, involving paramedics or Emergency Medical Technicians (Paramedic in America) working in an out-of-hospital, Anglo-American Emergency Medical Service (EMS) system were eligible for inclusion.Data extraction and synthesisOne reviewer used a data extraction template developed for this review and 10% of the papers were checked by the second author. Findings were summarised in tables and synthesised both quantitatively and qualitatively.ResultsThe search yielded 1268 primary sources, of which 48 were included in the review. Thirty-two papers examining KT interventions and 16 papers examining the barriers and facilitators to KT were found. Only one randomised controlled trial was found, and only one paper made explicit use of any KT framework. Overall, eight themes describing barriers and facilitators to KT arose from the qualitative literature, with clinicians’ perception of the evidence being the dominant theme. All 32 papers describing KT interventions included some form of educational intervention.ConclusionsOverall, there is little depth and breadth in the literature, with many papers focusing on trauma and airway management. There are large gaps in the evidence surrounding the use of KT theories and frameworks in Anglo-American EMS. Further research is needed to identify appropriate KT models and frameworks that are contextualised to EMS to ensure that paramedic-led research finds its way to the clinicians needing to use it.
Classifications of haemodialysis vascular access stenosis: a scoping review
Authors: Lawrie Katerina , O’Neill Stephen , Malik Jan , Janousek Libor , Corr Michael , Maly Stepan , Chlupac Jaroslav , Waldauf Petr 
Published: January 2025

ObjectivesVascular access (VA) stenoses play a significant role in the morbidity of the haemodialysed population. Classifications for diagnosis, assessment and proposal of treatment strategies can be useful clinical and methodological tools. This review aims to present a comprehensive summary and propose further methodological approaches.DesignA systematic review of the literature, evaluating classifications for dialysis-related VA stenosis.Data sourcesWeb of Science, Scopus, PubMed, Google Scholar and the ClinicalTrials.gov registry were searched from inception to 7 December 2024.Eligibility criteriaAll articles containing classifications regarding dialysis VA were eligible, with no restrictions on the study type or language of the full text.Data extraction and synthesisTwo independent researchers performed the search and initial screening. Four vascular surgeons assessed the included classifications using a modified Buchbinder’s critical appraisal tool to evaluate quality.ResultsFrom 4771 screened papers, 59 full-text papers were retrieved and 24 articles contained classifications. Three classifications were dedicated to VA stenosis, all based on the anatomical location of lesions. According to the modified Buchbinder’s appraisal, the classifications were assessed as moderate-to-good quality. The literature disposes of immense inconsistency in terms of the definition of significant stenosis indicated for treatment.ConclusionsVA significant stenosis and its classification is a non-uniformly understood issue with many different criteria and categorisations. This basic methodological problem leads to inconsistent results. We recommend the unification of the criteria and their validation in prospective studies.
Personal, occupational and cardiovascular risk factors associated with elevated blood pressure in Brazilian firefighters: a cross-sectional study
Authors: Sales Igor Magalhães , Damacena Fernanda Camargo , Zandonade Eliana , Sampaio Karla Nívea 
Published: January 2025

ObjectiveOur study evaluated the prevalence of hypertension in a population of Brazilian firefighters and the association of elevated blood pressure (BP) with personal, occupational, and cardiovascular risk factors.DesignThis was a cross-sectional study.SettingOur study was based on health inspections of the Military Fire Brigade of the Espírito Santo State, Brazil, performed in 2019.ParticipantsThe study participants were 859 male Brazilian firefighters.Outcome measuresData collected included sociodemographic (age, ethnicity, educational level, health insurance coverage), occupational (city of work, type of current activity, main operational activity), lifestyle (smoking and alcohol consumption), and health status (fasting glucose, total cholesterol and triglycerides, blood pressure, and anthropometric composition). All firefighters in the pre-hypertension and hypertension range and/or using antihypertensive medication were considered as having BP above normal, and the association of this outcome with sociodemographic, occupational, lifestyle, and health status variables was analysed by a logistic regression model.ResultsWe found that 45.6% of firefighters presented elevated BP levels. A higher chance of elevated BP was observed for firefighters with high school (1.5; 95% confidence interval (CI) 1.02 to 2.19) and postgraduate (1.54; 95% CI 1.03 to 2.30) educational levels, those self-declared as black (1.98; 95% CI 1.03 to 3.78), those working in countryside cities (ie, locations outside the metropolitan circuit; 2.32; 95% CI 1.14 to 4.71), and those with hypertriglyceridemia (1.92; 95% CI 1.19 to 3.11), hyperglycaemia (1.5; 95% CI 1.01 to 2.22), and central obesity (2.34; 95% CI 1.47 to 3.70).ConclusionWe found an association between elevated BP and personal, occupational, and cardiovascular risk factors. Awareness of risk factors may grant implementation of more effective intervention and prevention strategies.
Preferences of pregnant women and obstetric healthcare professionals on using noninvasive prenatal testing to predict adverse pregnancy outcomes: a discrete choice experiment
Authors: Becking Ellis , Akkerman Elisabeth , Scheffer Peter , Smith Ian , Stemkens Daphne , Bax Caroline J , Bekker Mireille N , Crombag Neeltje , Schuit Ewoud , Henneman Lidewij 
Published: January 2025

ObjectivesNoninvasive prenatal testing (NIPT) to screen for fetal aneuploidies by analysing cell-free DNA in maternal plasma is available to pregnant women worldwide. In the future, the scope of NIPT could potentially be expanded to the prediction of adverse pregnancy outcomes. The objective of this study was to assess and compare the preferences of pregnant women and obstetric healthcare professionals on this new test purpose of NIPT.DesignA discrete choice experiment was designed to assess participants’ preferences on the use of NIPT to predict adverse pregnancy outcomes regarding three attributes on test characteristics: test accuracy rate, unnecessary intervention rate and false reassurance rate. A questionnaire assessed general attitudes towards using noninvasive prenatal testing to predict adverse pregnancy outcomes.SettingDutch prenatal healthcare system.ParticipantsPregnant women with singleton pregnancies and obstetric healthcare professionals.ResultsIn total, 1580 pregnant women and 308 obstetric healthcare professionals participated in the discrete choice experiment. Higher test accuracy, fewer unnecessary interventions and less false reassurance all had a statistically significant (p<0.05) impact on the preference for a test. For pregnant women, the most important test characteristic when choosing a preferred test was the test accuracy rate, while for obstetric healthcare professionals, the most important test characteristic was the unnecessary intervention rate. The false reassurance rate was the least important test characteristic for both groups. Overall, 74% (n=1181) of pregnant women (strongly) agreed that NIPT to predict adverse pregnancy outcomes should be offered to pregnant women compared with 49% (n=151) of obstetric healthcare professionals.ConclusionsMost pregnant women have a positive attitude towards using NIPT to predict adverse pregnancy outcomes compared with slightly less than half of the obstetric healthcare professionals. Pregnant women prioritise a prognostic test with higher test accuracy, while obstetric healthcare professionals prioritise a test that results in fewer unnecessary interventions.
Symptom-related experience and sexual health of female patients with pulmonary arterial hypertension: protocol for a systematic review and qualitative meta-synthesis
Authors: Ma Fangfang , Yang Lixiao , He Ye , Yang Zhu 
Published: January 2025

IntroductionPulmonary arterial hypertension (PAH) is a complex condition affecting quality of life, characterised by high blood pressure in the pulmonary arteries leading to heart strain. PAH’s impact extends beyond physical symptoms, influencing emotional and social well-being, particularly in women where it affects sexual health and pregnancy outcomes. Despite medical advancements, the disease’s full impact on women’s lives is under-researched, especially regarding sexual experiences and health. This systematic review and qualitative meta-synthesis aim to address this gap by examining women’s experiences with PAH, informing clinical practice and patient-centred care. The protocol outlines a methodology for synthesising qualitative research to amplify women’s voices and enhance our understanding of PAH’s impact on female patients.Methods and analysisSearch strategy: A systematic review and thematic meta-synthesis of qualitative research studies and qualitative components of mixed-methods studies will be conducted. The systematic review will be guided by the Joanna Briggs Institute methodological framework. A comprehensive search will encompass seven electronic databases and search engines (Ovid Medline, CINAHL, EMBASE, APA PsycINFO, Cochrane Database of Systematic Reviews, PubMed, Scopus) and grey literature sources (ProQuest Dissertations, ClinicalTrials.gov). Building on insights from previous reviews centred on symptom-related experience and sexual health. Two review authors will independently conduct the screening and data extraction processes. Discrepancies will be resolved through consensus or discussion with a third review author. The review will include English studies from database inception. Findings will be presented graphically and tabularly, together with a narrative description.Assessment of confidence and data synthesis: The meta-synthesis used thematic analysis, importing study transcripts and notes into NVivo software. Data-derived codes formed categories, which were then iteratively refined into broader themes reflecting women’s experiences with sex and childbirth while living with PAH.Ethics and disseminationExternal ethical approval is not required as this review is a retrospective review, which is undertaking secondary analysis of publicly available primary data. The results will be disseminated in peer-reviewed journals and presented in conference papers and elsewhere. This protocol is registered with PROSPERO prospective database of systematic review.PROSPERO registration numberCRD42024529342.
Opioid agonist therapy discontinuation in British Columbia: a cross-sectional study of people who access harm reduction services
Authors: Ziafat Kimia , Liu Lisa , Kievit Bradley , Papamihali Kristi , Graham Brittany , Otterstatter Michael , Buxton Jane A 
Published: January 2025

ObjectivesThis study evaluates the prevalence and correlates of opioid agonist therapy (OAT) discontinuation across British Columbia (BC), using a sample of individuals who used substances and accessed harm reduction sites.DesignThis study uses data from the 2019 cross-sectional Harm Reduction Client Survey (HRCS).SettingThe 2019 survey was administered from October to December at 22 harm reduction supply distribution sites across the 5 Regional Health Authorities of BC.ParticipantsThe 2019 HRCS was administered among individuals who used illicit substances in the past 6 months and were aged 19 years and above.Primary and secondary outcome measuresThe primary outcome was defined as self-reported discontinuation of OAT in the past 6 months. Measures of association (χ2and Fisher’s exact tests) and logistic regression models were used to assess the strength of association between OAT discontinuation and demographic, socioeconomic, accessibility, drug use and harm reduction correlates.ResultsOf the 194 participants included, 59.8% self-identified as cis man, 37.6% self-identified as Indigenous, 38.1% were aged 30–39 years and 43.8% had discontinued OAT in the past 6 months. Multivariable logistic regression analyses identified that those aged ≥50 years (AOR=0.12, 95% CI (0.03 to 0.45)) and those who took the survey in medium/large urban areas (AOR=0.27, 95% CI (0.07 to 0.98)) were significantly less likely to discontinue OAT, while those who experienced an overdose in the past 6 months were significantly more likely (AOR=3.77, 95% CI (1.57 to 9.03)) to have discontinued OAT in the past 6 months. Substance use, including opioids and stimulants, was similar among those who continued and discontinued OAT. Of the 73 participants who discontinued OAT and provided a reason, one-third reported discontinuing OAT because treatment was not effective, 27.4% could not get to the pharmacy during open hours, 23.3% could not make their clinic appointment and 15.1% reported challenges with transportation/travel.ConclusionsOAT discontinuation prevention efforts for individuals using substances in BC need to address disparities in healthcare accessibility, especially in rural areas and among younger individuals. Continued access to harm reduction services can allow for safer consumption of substances for individuals enrolled in OAT programs.
Estimating the need for diabetic retinopathy services in north India: evidence from a population-based survey in the catchment population of an eye care provider in central Uttar Pradesh
Authors: Sabherwal Shalinder , McCormick Ian , Javed Mohd , Sood Ishaana , B R Shamanna , Buttan Sandeep , Majumdar Atanu , Chandi Simrat , Lakhani Basitali , Tyagi Shreya , Deep Utsav , Jain Vaibhav , Bastawrous Andrew 
Published: January 2025

ObjectiveThe aim of this study was to assess the prevalence of diabetic retinopathy (DR) and retina screening coverage among people with diabetes in the catchment area of a high-volume eye care organisation in north India.DesignA population-based cross-sectional study using Rapid Assessment of Avoidable Blindness survey, including the DR module.SettingA customised rural district in the catchment of Dr Shroff’s Charity Eye Hospital in Uttar Pradesh in north India.Participants4095 people of age 50 years and above were enrolled using a two-staged cluster sampling, 3867 (94.4%) participated; 2167 (52.9%) were women. 3803 of 4095 (92.9%) participants were assessed for diabetes. People with already diagnosed diabetes and anyone with a random blood glucose ≥200 mg/dL were offered dilated fundus examination.Primary and secondary outcomesPrimary and secondary outcomes were the prevalence of DR and screening coverage for DR, respectively.ResultsThe prevalence of diabetes was 7.0% (95% CI 5.9% to 8.0%). 50.2% of all people with diabetes were newly detected. The prevalence of any DR among people with diabetes who consented to dilated pupillary examination was 22.8% (51 of 224), (95% CI 18.2% to 27.3%). 5.8% (13/224) of people with diabetes were found to have sight-threatening DR and only 15.4% (2/13) had received treatment. 84.8% of people with previously diagnosed diabetes had never had their eyes tested for DR; this was significantly higher in women (90.2% vs 76.0%, respectively, p<0.001). 76% of people with previously diagnosed diabetes had poorly controlled diabetes; this was significantly higher for those on non-allopathic treatment (p<0.01). The odds of DR were higher with duration of diabetes >10 years and poor glycaemic control (OR of 1.8 and 1.6, respectively), but this was not found to be statistically significant.ConclusionThe prevalence of DR in this predominantly rural setting was found to be higher than the national average. Coverage of retinal screening and treatment was found to be very low. Working with general health providers to increase detection of people with diabetes and leveraging vision centres to improve DR screening coverage is needed in this region.
Intratumoral oncolytic virus OH2 injection in patients with locally advanced or metastatic sarcoma: a phase 1/2 trial
Authors: Tan Zhichao , Wu Yan , Fan Zhengfu , Gao Tian , Ding Sijuan , Han Liang , Luo Suxia , Fan Qingxia , Shi Jianhua , Bai Chujie , Xue Ruifeng , Li Shu , Zhang Lu , Wang Xinyu , Jia Ling , Zhou Lixin , Liu Binlei , Huang Jing , Liu Jiayong 
Published: January 2025

BackgroundIntratumoral oncolytic herpes simplex virus 2-GM CSF (OH2) injection has shown safety and antitumor efficacy in patients with solid tumors. Here, we examined the safety and efficacy of OH2 as a single agent or in combination with HX008, an NMPA-approved PD-1 inhibitor, in locally advanced or metastatic sarcoma patients.MethodsThis multicenter, phase 1/2 trial enrolled patients with injectable sarcoma lesions, who had failed at least 1 or more lines of standard treatment. Patients were treated with OH2 at three dose levels (106, 107and 108CCID50/mL) as single agent or in combination with a fixed dose of HX008. The primary endpoints were safety and tolerability in phase 1 and objective response rate determined by RECIST (V.1.1) criteria and immune-RECIST in phase 2.ResultsBetween October 20, 2020 and December 30, 2023, 26 patients were enrolled. Seven patients were treated with single-agent OH2 and 19 with HX008 and OH2 combination. No dose-limiting toxicities were observed during the dose escalation. We documented four partial or complete responses in injected lesions, and one partial response in non-injected lesions, which were all from the combination group. Hence, the overall response rate was 0% and 16.7% in the single agent and combination groups, respectively. The duration of response was 3.9–6.5 months. The most frequent treatment-related adverse events (TRAEs) were fever (n=9). Grade 3 or 4 TRAEs were reported in four patients (15.4%). A clear increase in CD8+cell density in the tumor microenvironment was observed in the patients’ post-treatment specimens compared with baseline.ConclusionsIntratumoral injection of oncolytic virus OH2 is well tolerable in patients with sarcoma. Further investigation of OH2 with HX008 in select sarcoma subtypes is warranted.
PURA-related neurodevelopmental disorders: a systematic review on genotype-phenotype correlations
Authors: Taniguchi Noritaka , Watanuki Keisuke , Nakato Daisuke , Takenouchi Toshiki , Kosaki Kenjiro , Koga Hiroshi 
Published: January 2025

IntroductionGenotype-phenotype correlations inPURA-related neurodevelopmental disorders (PURA-NDDs) remain unclear. This systematic review aimed to clarify these correlations.MethodsSearches of PubMed and Embase were conducted on 8 August 2024 to identify studies that had investigated genetically diagnosedPURA-NDDs (5q31.3 deletion syndrome and PURA syndrome). All types and languages of studies were included. Study quality was assessed using a 20-item criterion checklist. Genetic and clinical data were extracted from each article and genotype-phenotype correlations were explored.ResultsOur analysis included 46 studies encompassing 230 patients withPURA-NDDs (5q31.3 deletion syndrome 18 (8%) and PURA syndrome 212 (92%)). Patients with 5q31.3 deletion syndrome exhibited more congenital defects (50% vs 12%, p<0.0001), respiratory difficulties (94% vs 63%, p=0.013) and walking disability (94% vs 55%, p=0.0026) than patients with PURA syndrome. In PURA syndrome, protein-truncating (nonsense or frameshift) variants were associated with more speech deficits (93% vs 80%, p=0.014) than non-protein-truncating (missense or in-frame) variants.PURAvariant location had no effect on congenital defect occurrence or neurodevelopmental outcome. Overall, respiratory difficulties, walking disability and speech deficits were more commonly observed in the following order: 5q31.3 deletion (94%, 94% and 100%, respectively), multiple PUR-repeat deletions (68%, 60% and 95%, respectively), single PUR-repeat deletion or alteration (61%, 53% and 85%, respectively), and deletion or alteration located outside PUR repeats (38%, 33% and 43%, respectively).ConclusionThe clinical severity ofPURA-NDDs appears to be associated with the deletion/alteration size including PUR repeats rather than the location ofPURAvariants.
Development and Evaluation of an Automated Multimodal Mobile Detection of Oral Cancer (mDOC) Imaging System to Aid in Risk-based Management of Oral Mucosal Lesions
Authors: Mitbander Ruchika , Brenes David , Coole Jackson B. , Kortum Alex , Vohra Imran S. , Carns Jennifer , Schwarz Richard A. , Varghese Ida , Durab Safia , Anderson Sean , Bass Nancy E. , Clayton Ashlee D. , Badaoui Hawraa , Anandasivam Loganayaki , Giese Rachel A. , Gillenwater Ann M. , Vigneswaran Nadarajah , Richards-Kortum Rebecca 
Published: January 2025

Abstract
Oral cancer is a major global health problem. It is commonly diagnosed at an advanced stage although often preceded by clinically visible oral mucosal lesions, termed oral potentially malignant disorders associated with an increased risk for oral cancer development. There is an unmet clinical need for effective screening tools to assist front-line healthcare providers to determine which patients should be referred to an oral cancer specialist for evaluation. This study reports the development and evaluation of the mobile Detection of Oral Cancer (mDOC) imaging system and an automated algorithm that generates a referral recommendation from mDOC images. mDOC is a smartphone-based autofluorescence and white light imaging tool that captures images of the oral cavity. Data were collected with mDOC from a total of 332 oral sites in a study of 29 healthy volunteers and 120 patients seeking care for an oral mucosal lesion. A multimodal image classification algorithm was developed to generate a recommendation of “Refer” or “Do Not Refer” from mDOC images, using expert clinical referral decision as the ground truth label. A referral algorithm was developed using cross-validation methods on 80% of the dataset, then retrained and evaluated on a separate holdout test set. Referral decisions generated in the holdout test set had a sensitivity of 93.9% and a specificity of 79.3% with respect to expert clinical referral decisions. The mDOC system has the potential to be utilized in community physicians’ and dentists’ offices to help identify patients who need further evaluation by an oral cancer specialist.