bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk Factors, Symptomatology, and Predictors of Mortality among COVID-19 Inpatients Presenting with Delirium Symptoms in a Tertiary Hospital in the Philippines
Authors: Factor Sedric John , Ly-Uson Josefina , Aligam Katrina Joy , Gelvezon Marie Angelique 
Published: January 2023

Abstract
INTRODUCTION Delirium is a common but under-recognized finding among patients with COVID-19. This study aimed to describe the risk factors, symptomatology, and predictors of mortality of COVID-19 patients presenting with delirium symptoms admitted in 2021 to the Philippine General Hospital, a public tertiary hospital in the Philippines.
METHODS Medical records of adult COVID-19 patients admitted to the Philippine General Hospital in 2021 were analyzed. Descriptive statistics were used to summarize the demographic and clinical history. Univariate and multivariate logistic regression were done to determine the variables that are predictive of mortality.
RESULTS Four hundred patients with COVID-19 had delirium symptoms. Of those, 36.5% were not diagnosed with delirium, only 7% were referred to Psychiatry, and 74% expired during their admission. Patients referred to Psychiatry have lower odds of mortality compared to those not referred (aOR=0.069, p=0.014); those that received midazolam had higher odds of mortality (aOR=3.112, p=0.001). Patients on mechanical ventilation (aOR=20.172), those placed on prone positioning during mechanical ventilation (aOR=6.272), those with decreased sensorium (aOR=7.438), and those with decreased psychomotor activity (aOR=3.857) all had higher odds of mortality (p<0.001).
CONCLUSIONS Timely assessment and appropriate management are critical for COVID-19 patients with delirium symptoms, especially those at an increased risk for mortality. Clinicians dealing with COVID-19 patients presenting with delirium symptoms need to be reoriented to delirium symptomatology, initial interventions, and indications for referral to psychiatrists.
Secure Framework to Enhance Security Using Hybrid Algorithm in Cloud Computing With Ssl
Authors: F MARGRET SHARMILA , K KARUPPASAMY 
Published: January 2023

Abstract
In the last several years, cloud computing has grown at a very rapid pace.With a growing number of enterprises relying on cloud-based services, it's more important than ever to protect the data of many users who utilise centralised resources.The privacy, preservation, and management of a user's data are just a few of the issues that Cloud Computing has to deal with. The fundamental purpose is to understand security risks in Cloud Computing and to discover efficient security measures for reducing them, as listed below. To get a better comprehension of the security situation concerns and approaches employed in today's world of Cloud Computing the hybrid SSL based Crpto System is proposed .To propose countermeasures to the future Cloud Computing's issues may confront. Various security specialists working on Cloud Computing were surveyed and interviewed. The proposed approach employ SSL or IPSec to protect the communication route between the users, the cloud, and the cryptographic server. A piece of software was created to encrypt a user's data , this is how we plan to address the security breaches that have occurred in recent years and protect data in the cloud from emerging threats
Specific Parameters of Detection of Fungi of the Genus <i>Aspergillus</i> in Respiratory Organs of Pulmonary Tuberculosis Patients
Authors: Panova A. E. , Lovacheva O. V. , Gracheva A. N. , Burmistrova I. A. , Naumova T. A. , Tyulkova T. E. 
Published: January 2023

The objective: to study specific parameters of detection of fungi of the genus Aspergillus in respiratory organs of pulmonary tuberculosis patients.Subjects and Methods. In 2019-2021, the samples of sputum or bronchoalveolar lavage of 520 patients above 18 years old with confirmed pulmonary tuberculosis and HIV-negative status were tested for molds. Also, all patients had their sputum or BAL tested for acid fast mycobacteria (AFB), cultures of M. tuberculosis (MBT), and DNA of tuberculous mycobacteria.Results. Positive culture results for fungi were obtained in 50/520 (9.62%; 95% CI 7.37-12.45, Wilson test) pulmonary tuberculosis patients. Species identification revealed fungi of the genus Aspergillus in 46/50 (92%) of them.In 37/46 (80.43%; 95% CI 66.83-89.35) patients, a single type (one species of Aspergillus) was identified, in 9/46 (19.57%; 95% CI 10.65-33.17) two types were identified. A. fumigatus (16/37 isolates, 43.24%) and A. niger (13/37 isolates, 35.14%) prevailed among single types of cultures. A. niger + A. flavus (3/9 isolates, 33.33%) was the most frequent combination. The ratio of the effectiveness of methods for detecting fungi such as culture/direct microscopy/galactomannan antigen in serum and BAL was 100/84.78/4.35% and 67.39%, respectively. Thus, BAL is more preferable than serum for detection of galactomannan antigen in patients with tuberculosis.Only in 8/46 (17.4%) patients, bacterial excretion was detected by culture, which is typical for the active phase of the course of tuberculosis. In the remaining 38 (82.6% 95% CI 69.28-90.91) patients, no tuberculous mycobacteria were detected by culture, which was typical of stabilization and cure of tuberculosis.
A incorporação do ODS 16 pelo Judiciário Brasileiro
Authors: Vitória Paulo Renato , Ribeiro Mangueira Marques Iracy 
Published: January 2023

Este artigo analisa, a partir de uma perspectiva crítica da colonialidade, as possibilidades e os limites decorrentes da incorporação da Agenda 2030 da ONU pelo Poder Judiciário Nacional, precisamente no tocante ao ODS 16. Primeiramente, elencamos alguns dos principais aspectos normativos referentes à adesão a essa pauta e a recepção do PNUD como consectários da preocupação do órgão de cúpula da Justiça Brasileira com a qualidade e aprimoramento da entrega jurisdicional. Prosseguimos com uma análise crítica da pretensão de universalidade da visão ocidental de direitos humanos, relacionando-a com o conceito de colonialidade do poder, de Quijano (1992). Em seguida, problematizamos o conceito de desenvolvimento que subjaz o ODS em questão, tomando em conta o capitalismo estruturalmente dependente que caracteriza a nossa região, como também os paradoxos do crescimento econômico enquanto critério implícito na pauta onusiana. Finalmente, diante dessas reflexões e considerando os limites das concepções hegemônicas de direitos humanos e desenvolvimento, discutimos algumas condicionantes estruturais, contextuais e interseccionalidades que desafiam a construção de novas metodologias, mediações e ferramentas que possam permitir a integração dessa pauta pelo Judiciário. Apontamos alguns possíveis caminhos horizontais, dialógicos, transmodernos e pluriversais, coerentes com as particularidades, as contradições materiais e as especificidades da realidade brasileira.
Relationship between Jordanian Undergraduate Nursing Students' Perception of Empowerment and the Academic Satisfaction: Descriptive Study
Authors: Al-niarat Tahany , Abomoghli Fathieh 
Published: January 2023

Background
Nursing students' perception of empowerment has an important impact on their learning process and learning outcomes.

Aim
This study aimed to assess the relationship between undergraduate nursing students' perception of empowerment and their academic satisfaction in Jordan.

Methodology
A descriptive, correlation design was used in this study, 164 fourth-year nursing students were selected to participate by convenience sampling method. The universities with the largest number of students were selected according to region (north, middle, south), and sectors (3private and 2public). The data collection methods included are: an Arabic version of self-reported questionnaires, the Learner Empowerment Scale (LES) to assess nursing students' perception of empowerment, and The Undergraduate Nursing Students Academic Satisfaction Scale (UNSASS) to assess nursing student’s agreement with academic satisfaction.

Results
Data were analyzed using descriptive and inferential statistics, 164 out of 184 students completed and returned the questionnaires with a response rate of 90%. Participants showed moderate perception of empowerment with a mean score is 79 out of (0-140) (SD=17.35). Pearson analysis showed a strong correlation between students' perception of empowerment and their academic satisfaction at all subscales: In-class teaching, clinical teaching, program design and delivery, and support and resources respectively as following: r (162) = +.37. P<0.01, r (162) = +.27, p<0.01, r (162) = .26, p<0.01, and r (162) = .30, p<0.01.

Conclusion and Implications
This is the first study conducted in Jordan that contributed to the body of literature on undergraduate nursing students' perception of empowerment and the relation of their satisfaction with learning environment. The results highlighted the essence of teaching-learning context and methods to empower the students. Thus, more efforts should focus on clinical training, clinical placement, and diversity of teaching strategies to match the educational requirement to reduce the theory-practice gap.
Decoding Vehicle Motion Data on the Internal Network
Authors: Ghadi Maen Qaseem 
Published: January 2023

Background
Encrypting functions of vehicle internal networks make the lives of third parties more difficult since, in most cases, the meaning of messages carried by the CAN bus is not disclosed
Objectives
This paper proposes a reverse engineering method to discover, to a large extent, the semantics of CAN messages in a vehicle internal network.
Methods
A filtering mechanism has been applied that includes several statistical processes to interpret the codes of CAN messages. The speed change function of a vehicle has been chosen as an example to be followed in the development steps of this approach to predict the motion mechanism of the vehicle. The selected codes were verified by developing a multilevel model that relates the hierarchical relationship between the bytes and IDs and their impact on the speed factor.
Results
The most influential IDs and bytes on vehicle speed function were: ID 512, ID 520, ID 664, and B2, B4, B6, respectively.
Conclusion
The selected codes used to model the observed speed do not mean they all share the speed function, but there is a good possibility that at least some fulfill this function. However, the same methodology can be applied, with some optimization, to detect other semantic messages in the CAN network based on the expected type of data.
Nanostructured Etodolac Carriers in Transdermal Gel: Optimization and
Characterization
Authors: Patil Poonam , Shirkhedkar Atul 
Published: January 2023

Aims:
To optimize, formulate, and evaluate a Nanostructured Lipid Carrier (NLC)
based transdermal gel of Etodolac (ETD).

Objective:
To avoid issues of conventional route ETD administration like first pass metabolism,
gastric ulceration, hemorrhage, and being a class-II drug with less solubility. A transdermal gel of
nanostructured lipid carrier for ETD has been developed. Formulation will execute faster onset of
action, increased penetration, permeation with extended release of the drug for a longer duration.

Methods:
A central composite 32 factorial design is used to plan experiments. NLCs are prepared
by the method of melt emulsification and ultrasonication. Compritol 888ATO and Miglyol are
used as solid and liquid lipid phases. Surfactant Pluronic F68 showed a significant effect on particle
size, entrapment efficiency, and drug release. Particle size characterized using photon correlation
spectroscopy and scanning electron microscopy. Cumulative drug release studied using an
artificial diffusion cell and a dialysis membrane. A skin permeation study was performed using
goat skin at 32°C ± 0.5°C. The efficacy of the NLC gel was verified using a pharmacodynamic
study followed by stability study for 3 and 6 months.

Results:
The optimized batch of ETD NLC found spherical with a 241.3 nm particle size with
0.392 PDI,-29 mV zeta potential. Entrapment efficiency and cumulative drug release were found
to be 64.21 ± 1.23% and 70.12 ± 2.10% (after 12 hours), respectively. All batches followed zeroorder
drug release kinetics and non-Fickian (Super Case II transport) with 0.1619 mg/cm2/hr
transdermal flux. The NLC gel of ETD showed a quick onset and lengthened therapeutic activity
until 24 hours compared to the micellar ETD gel.

Conclusion:
Etodolac NLC batch successfully optimized using central composite design. The
relationships between the components of the NLC-total lipid:drug and surfactant-and the outcomes-
particle size,%entrapment and% drug release-were better understood by examining several
contour plots. The results of the experimental and predicted formulations were found to be in good
agreement with slight bias, demonstrating the reliability of the optimization process.
NMR-based Phytochemical Profiling of Palmyra Palm Syrup Infused with
Dry Ginger, Black Pepper, and Long Pepper
Authors: Reshma Mullan Velandy , Lankalapalli Ravi Shankar , Athira Ambili Sasikumar , Kiruthika Ramkumar , Ingaladal Nagaraja , Krishnakumar Karunakaran Anitha , Raveena Natakkakath Kaliyathan , Gopika Biju 
Published: January 2023

Background:
Trikatu, a vital ingredient in many Indian Ayurvedic drugs, is a consortium of
three spices, viz. dry ginger, black pepper, and long pepper, known for its peculiar pungency. To convert
Trikatu into a widely acceptable palatable form, we blended these three spices in a decoction form
and added them to syrup prepared from palmyra palm neera, which resulted in ‘Trikatu Syrup’ (TS).
Recently, we reported in vivo immunomodulatory properties of TS.

Introduction:
The immunomodulatory effects of spices are attributed largely to the presence of certain
phytochemicals. The importance of phytochemicals in spices as immunomodulatory agents necessitate
a thorough investigation of these bioactives in formulations comprising spices. In the present study, we
have focused on understanding the retention of spice and syrup-based phytochemicals in the formulated
product that assists in product standardization of TS.

Methods:
NMR serves as a highly reliable tool for explicit structural confirmation of phytochemicals
when compared to HPLC or mass spectrometry tools. NMR spectra of a phytochemical, whether in
pure form or when the phytochemical is a part of the mixture, enable qualitative and quantitative studies
with a mixture of phytochemicals in organic extracts of food matrices. Hence, the NMR spectral
comparison of compounds isolated from the organic extracts of TS is described here.

Results:
Fractionation of TS using Diaion® HP-20 resulted in the partitioning of compounds based on
their polarity. Purification of the acetone fraction by column chromatography aided in the efficient
isolation of compound 1 (pellitorine), compound 2 (piperine), compounds 3-5 (trienamides), and compound
6 (pipataline). Acetonitrile fraction yielded compound 7 (uridine) and compound 8 (3-O-methylmyo-
inositol), which were neither reported in the three spices nor palmyra palm. A qualitative display of
the acetone fraction of TS with its phytochemicals 1-6 served as a fingerprint of TS.

Conclusion:
In summary, TS, a palatable spice-based nutraceutical in palmyra palm syrup with immunomodulatory
potential, was thoroughly investigated for the phytochemical composition of its organic
fractions. The process of fractionating TS using Diaion® HP-20, subsequent flash purification,
and column chromatography facilitated the isolation of prominent phytochemicals. We report the utility
of NMR as a reliable and efficient tool for fingerprinting phytochemicals in formulations, nutraceuticals,
etc., which assists in ascertaining their authenticity.
Pemberian Berbagai Level Air dan Pengaruhnya Pada Pertumbuhan dan Hasil Tanaman Kedelai (<i>Glycine max</i> (L) Merr) Varietas Grobogan
Authors: Mahardika Yusthian Hendra , Simanjuntak Bistok Hasiholan 
Published: January 2023

Faktor ketersediaan air tanah menjadi faktor pembatas pertumbuhan dan hasil kedelai. Oleh karena itu tujuan penelitian adalah mengetahui pengaruh pemberian berbagai level kadar air tanah terhadap pertumbuhan dan hasil tanaman kedelai varietas Grobogan. Tata letak penelitian dengan Rancangan Acak Kelompok (RAK), terdiri atas 4 perlakuan pemberian air sebanyak kadar air tanah 25% kapasitas lapang (P1), kadar air tanah 50% kapasitas lapang (P2), kadar air tanah 75% kapasitas lapang (P3), kadar air tanah 100% kapasitas lapang (P4). Masing-masing perlakuan diulang 6 kali. Data penelitian terdiri atas prolin daun, stress index (SI), tinggi tanaman, berat kering tanaman, jumlah polong per tanaman dan berat biji per hektar. Data dianalisis dengan Analisis Sidik Ragam dan dilanjutkan dengan Uji Beda Nyata (BNJ) dengan taraf kepercayaan 95%. Pemberian air mempengaruhi produksi prolin, pertumbuhan dan hasil tanaman kedelai varietas Grobogan. Akumulasi prolin dalam tanaman semakin meningkat ketika tingkat cekaman kekurangan air semakin tinggi. Pemberian air 75% kapasitas lapang mengakibatkan cekaman kekeringan tanaman kelas rendah, sedangkan tinggi tanaman kedelai, bahan kering tanaman, jumlah polong, dan berat gabah tidak berbeda nyata dengan pemberian air 100% kapasitas lapang. Pemberian air 50% kapasitas lapang mengakibatkan cekaman kekeringan tanaman kelas sedang dan secara nyata menurunkan tinggi tanaman. Pemberian air 25% kapasitas lapang mengakibatkan cekaman kekeringan tanaman kelas tinggi dan pada kondisi demikian terjadi penurunan secara nyata pada tinggi tanaman, berat kering tanaman, jumlah polong dan berat biji per hektar serta terjadi penurunan hasil hingga 69% jika dibandingkan dengan pemberian air 100% kapasitas lapang.
Circulating levels of Interferon regulatory Factor-5 correlates with disease activity in Systemic Lupus Erythematosus Iraqi patients
Authors: Dahham Zainab M. , Haddad Namir I. A. 
Published: January 2023

Objectives: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by a diversity of the phenotypes among the patients. SLE is still one of the great challenges due to the lacking of specific biomarkers for diagnosis, assessing disease activity, and prediction of response to therapy. This study aimed to investigate the role of circulating levels of IRF5 protein in sample of SLE Iraqi patients and its correlation with disease activity, to identify a potential immunological biomarker to mirror disease activity.
Methods: Blood samples were taken from 59 participants diagnosed with SLE cases classified according to the American College of Rheumatology (ACR) criteria. They were scored through the SLE disease activity index 2000 (SLEDAI-2K) to estimate the disease activity, and according to it they were subdivided into “SLE-1 group” (SLEDAI-2k ≤5), and “SLE-2 group” (SLEDAI-2k >5), as well as age and gender matched healthy control group. Circulating levels of IRF5 protein were measured in sera samples by ELISA method.
Results: Our result revealed that the circulating levels of IRF5 protein were significantly higher in the SLE-2 group rather than control group (p<0.01), while there was a non-significant difference between SLE-1 group and control group (p>0.05), as well as between both SLE patient groups. Moreover, the circulating IRF5 protein levels were found to be correlated positively and significantly with disease activity index in both SLE patient groups. The correlation between the circulating levels of IRF5 protein with other parameters revealed that a significant positive correlation was found in SLE-1 group with ESR and globulins, and negative correlation with Hb and (albumin/ globulin) ratio, while in SLE-2 group were positively correlated with urea, creatinine, and uric acid. The analysis of receiver operator curves (ROC) for circulating levels of IRF5 protein in SLE-1 and SLE-2 groups showed a good accuracy to distinguish SLE patients from healthy individuals (AUC=0.758, sensitivity=65.5%, and specificity=69%,), and (AUC=0.788, sensitivity=77.3%, and specificity=72.0%,), respectively.
Conclusions: The circulating levels of IRF5 protein correlate with disease activity in SLE patients reflects the possibility of using it as a potential immunological biomarker for diagnosis, and monitoring the disease activity.
Estratégias de diferenciação da commodity de café
Authors: Albieri Ana Carolina de Souza , Terra Leonardo Augusto Amaral 
Published: January 2023

Objetivo: O objetivo deste estudo é identificar as potenciais estratégias de geração de valor para diferenciação da commodity de café.
Método: O método consistiu em um estudo de caso instrumental, por meio entrevistas semiestruturadas com representantes de toda cadeia produtiva de cafés. Os dados obtidos foram analisados por meio do Tropes, categorizados e analisados no Excel e utilizados para produzir um mapa cognitivo que representasse as relações entre os resultados.
Principais resultados: Foi constatado um distanciamento entre o que pensa o produtor e o consumidor e um maior alinhamento das torrefadoras, cafeterias e pontos de vendas com os anseios dos primeiros.
Relevância/originalidade: A comercialização do café como commodity, tornou o produtor vulnerável a bruscas oscilações de preço de mercado, criando a necessidade de uma alterativa estratégica para diferenciação e geração de valor. Este trabalho contribui em trazer um direcionamento para orientar os produtores sobre como diferenciar seus produtos diante das novas realidades do mercado mundial de café.
Contribuições teóricas/metodológicas: Este trabalho identificou que há, uma divergência em relação à percepção de valor entre o produtor e o consumidor final que aponta como características de qualidade o bom sabor, o café forte e a marca. Hoje, a torrefadora é a principal responsável por gerar valor ao produto, ao ligar os anseios do cliente ao produtor. Para diferenciar seus produtos, o produtor precisaria assumir uma posição mais próxima do cliente final, verticalizando sua operação e compreendendo melhor os anseios do cliente final.
A relação entre a divulgação de inovação e assimetria de informação no Brasil
Authors: Vasconcelos Renata Braga Berenguer de , Santos Joséte Florencio dos 
Published: January 2023

Objetivo: O estudo buscou analisar as estratégias de divulgação da inovação realizada pelas companhias brasileiras de capital aberto e verificar seus impactos sobre a assimetria de informação.
Método: As estratégias de divulgação da inovação foram analisadas através de 71 relatórios anuais emitidos por companhias brasileiras negociadas na B3, identificando-se seis categorias de análise: Estratégia focada em inovação, Objetivos da inovação, Alianças realizadas, Planejamento financeiro, Resultados da inovação e Prêmios obtidos. A relação entre as categorias e a assimetria de informação foi analisada por meio de modelagem de equações estruturais.
Principais resultados: Os resultados indicaram que as divulgações sobre estratégias referentes às inovações, alianças realizadas, planejamento financeiro e os prêmios obtidos podem reduzir a assimetria de informação.
Relevância/originalidade: Estudo anteriores buscam analisar a divulgação da informação, e não tratam especificamente, da inovação. Contudo, ainda que tais divulgações sejam permeadas por um sigilo, elas podem serem refletidas na negociação dos ativos.
Contribuições teóricas/metodológicas: O estudo se destaca ao apresentar um modelo para análise da qualidade da divulgação da inovação, permitindo avaliar a extensão das informações. Diferentemente, estudos anteriores procuram avaliar o volume de informações divulgadas. Ademais, traça uma relação direta sobre a assimetria de informação