bluuebunny/crossref_metadata_2025_split huggingface dataset:
Causal effect of psychiatric disorders on epilepsy: A two‐sample Mendelian randomization study
Authors: Li Gongfei , Wang Minghui , Zheng Meiqi , Liu Xiao , Yu Tingting , Ren Jiechuan , Wang Qun 
Published: March 2023

AbstractBackgroundThis study aims to explore the relationship between psychiatric disorders and the risk of epilepsy using Mendelian randomization (MR) analysis.MethodsWe collected summary statistics of seven psychiatric traits from recent largest genome‐wide association study (GWAS), including major depressive disorder (MDD), anxiety disorder, autism spectrum disorder (ASD), bipolar disorder (BIP), attention deficit hyperactivity disorder (ADHD), schizophrenia (SCZ), and insomnia. Then, MR analysis estimates were performed based on International League Against Epilepsy (ILAE) consortium data (ncase = 15,212 and ncontrol = 29,677), the results of which were subsequently validated in FinnGen consortium (ncase = 6260 and ncontrol = 176,107). Finally, a meta‐analysis was conducted based on the ILAE and FinnGen data.ResultsWe found significant causal effects of MDD and ADHD on epilepsy in the meta‐analysis of the ILAE and FinnGen, with corresponding odds ratios (OR) of 1.20 (95% CI 1.08–1.34, p = .001) and 1.08 (95% CI 1.01–1.16, p = .020) by the inverse‐variance weighted (IVW) method respectively. MDD increases the risk of focal epilepsy while ADHD has a risk effect on generalized epilepsy. No reliable evidence regarding causal effects of other psychiatric traits on epilepsy was identified.ConclusionsThis study suggests that major depressive disorder and attention deficit hyperactivity disorder may causally increase the risk of epilepsy.
Three New Steriodal Saponins from the Rhizomes of Tupistra chinensis Baker
Authors: He Xuefeng , Yuan Xiaofeng , Liu Yang , Qiu Pengcheng , Bi Linlin , Tang Haifeng , Lu Yunyang 
Published: March 2023

AbstractThe phytochemical constituent investigation on the 70 % ethanol extract of the rhizomes of Tupistra chinensis Baker resulted in the isolation of three new steroidal saponins which were named tuchinosides A–C (1–3). Their structures were determined by extensive spectrum analysis and chemical evidence, especially 2D NMR and HR‐ESI‐MS techniques. In addition, the cytotoxicity of compounds 1–3 against several human cancer cell lines was evaluated.
Dynamic expression of H19 and MALAT1 and their correlation with tumor progression biomarkers in a multistage hepatocarcinogenesis model
Authors: El‐Daly Sherien M. , El‐Bana Mona A. , Abd El‐Rahman Sahar S. , Latif Yasmin Abdel , Medhat Dalia 
Published: March 2023

AbstractHepatocellular carcinoma (HCC) progresses sequentially in a stepwise pattern. Long noncoding RNA (lncRNA) can regulate the complex cascade of hepatocarcinogenesis. Our study aimed to elucidate the expression profile of H19 and MALAT1 during the different stages of hepatocarcinogenesis and the correlation between H19 and MALAT1 with the genes implicated in the carcinogenesis cascade. We employed a chemically induced hepatocarcinogenesis murine model to mimic the successive stages of human HCC development. Using real‐time PCR, we analyzed the expression patterns of H19 and MALAT1, as well as the expression of biomarkers implicated in the Epithelial‐Mesenchymal transition (EMT). The protein expression of the mesenchymal marker vimentin was also evaluated using immunohistochemistry in the stepwise induced stages. The histopathological evaluation of the liver tissue sections revealed significant changes during the experiment, with HCC developing at the final stage. Throughout the stages, there was a dynamic significant increase in the expression of H19 and MALAT1 compared to the normal control. Nevertheless, there was no significant difference between each stage and the preceding one. The tumor progression biomarkers (Matrix Metalloproteinases, vimentin, and β‐catenin) exhibited the same trend of steadily increasing levels. However, in the case of Zinc finger E‐box‐binding homeobox 1 and 2 (ZEB1 and ZEB2), the significant elevation was only detected at the last stage of induction. The correlation between lncRNAs and the tumor progression biomarkers revealed a strong positive correlation between the expression pattern of H19 and MALAT1 with Matrix Metalloproteinases 2 and 9 and vimentin. Our findings imply that genetic and epigenetic alterations influence HCC development in a stepwise progressive pattern.
Adult‐onset Still's disease after SARS‐Cov‐2 infection
Authors: Achour Tayssir Ben , Elhaj Wiem Ben , Jridi Maysam , Naceur Ines , Smiti Monia , Ghorbel Imed Ben , Lamloum Mounir , Said Fatma , Houman Mohamed Habib 
Published: March 2023

AbstractAdult‐onset Still's disease (AOSD) is an uncommon inflammatory disorder. AOSD and SARS‐Cov‐2 infection share clinical and laboratory features, including systemic inflammation. A 19‐year‐old woman had prolonged fever for 3 weeks, joint pain, and biological inflammatory syndrome. Post COVID‐19 AOSD was diagnosed. SARS‐Cov‐2 infection induces many inflammatory diseases including AOSD.
Intravenous plus intravitreal erythropoietin for management of methanol toxicity optic neuropathy: A case report and brief review
Authors: Rashidi Alavijeh Mehran , Mazaheri‐Tehrani Sadegh , Saffari Amir Sepehr , Fazel Mohammadreza , Fazel Farhad 
Published: March 2023

AbstractMethanol can inhibit cellular aerobic respiration pathway and causes cell hypoxia specially in optic neurons. Despite using many drugs, methanol‐induced optic neuropathy (MION) still has a poor prognosis. Here we present a case of MION which is managed by a combination of intravenous and intravitreal erythropoietin in addition to corticosteroids.
Bereit für die Gigafabriken von morgen
Authors: Manke David 
Published: March 2023

AbstractDie Ystral‐Technologie verkürzt die Prozesszeit zur Herstellung von Lithium‐Ionen‐Elektroden‐Slurries. Sie saugt Pulverstoffe staubfrei unter Vakuum in einen Flüssigkeitsstrom ein und ermöglicht dadurch eine Dispergierung der Pulverpartikel innerhalb von Millisekunden. Im Produktionsmaßstab erzielt die neue Lösung eine mehr als 10‐fach höhere Produktivität im Vergleich zu gängigen Planetenmischern.
Verknüpfte Datenbanken in der Prozessindustrie
Authors: Ochsenreither Steffen 
Published: March 2023

AbstractJeder Hersteller in der Prozess‐Automatisierung baut eigene IIoT‐Anwendungen und damit verknüpft eigene Cloud‐Lösungen. Die Integration von Informationen aus dem IIoT‐ökosystem Netilion von Endress+Hauser in führende Systeme, bspw. in das SAP Business
A Tetravalent Plutonium Organic Framework Containing [Pu2O16] Dimers as Secondary Building Units: Synthesis, Structure, and Radiation Stability
Authors: Zhang Yugang , Du Yingzhe , Li Lili , Tao Ye , Li Kai , Zhang Hailong , Wang Yanlong , Chen Lanhua , Wang Yaxing , Chai Zhifang , Wang Shuao 
Published: March 2023

Comprehensive SummaryThe second example of tetravalent plutonium carboxyl‐based organic framework, 242Pu(OH)[PO[(C6H4)COO]3]·H2O, termed as PuTPO (TPO = tris(4‐carboxylphenyl)‐phosphineoxide), was reported in this work. A series of characterizations of PuTPO, such as X‐ray crystallography and solid‐state UV‐Vis‐NIR spectroscopy, were carried out to expatiate its structure and physicochemical properties. PuTPO is constructed by dimers of the plutonium‐oxygen subunit of [Pu2O16]. Characteristic peaks located at approximately 1100 nm can be considered to be the fingerprint peaks of tetravalent plutonium. While PuTPO can maintain high crystallinity within several months after synthesis, it exhibits a radiation‐induced swelling effect probed by the expansion of cell parameter of b axis after self‐irradiation from α‐decay of 242Pu. This result enriches the inventory of tetravalent plutonium compounds and provides an insight into the irradiation resistance of metal‐organic frameworks.
Supercritical carbon dioxide technology in synthesis, modification, and recycling of battery materials
Authors: Han Yiyao , Zhou Xiaozheng , Fang Ruyi , Lu Chengwei , Wang Kun , Gan Yongping , He Xinping , Zhang Jun , Huang Hui , Zhang Wenkui , Xia Xinhui , Xia Yang 
Published: March 2023

AbstractFor pursuing the ambitious goals in the burgeoning electric vehicles, portable electronic devices, and energy storage sectors, Li‐ion batteries (LIBs) are considered as one of the most promising electrochemical power sources because of their high energy density and moderate cost. Particularly, the improvement of battery materials and recycling of spent LIBs are receiving great attention since the sustainable approaches for the synthesis, modification, and recycling of battery materials are the crucial factors to the successful large‐scale implementation of LIBs. In this regard, supercritical carbon dioxide (SC‐CO2), which possesses many merits, such as environmentally friendly, low‐cost, individual chemical environment, and especially its unique physical properties, has been employed as solvent and reaction medium in the synthesis and modification of diverse functional materials. In this review, we mainly aim at compiling the applications of SC‐CO2 technology in the synthesis and modification of electrode materials as well as the recycling of LIBs. First, the unique properties and principles of SC‐CO2 technology are highlighted. Second, the latest progresses of the electrode materials design and recycling with the assistance of SC‐CO2 technique are summarized. Finally, the challenges, future directions, and perspectives on the design and development of battery materials and battery recycling by SC‐CO2 technology are proposed.
Existential isolation and prolonged grief in bereaved people: The moderating role of culture
Authors: Zhou Ningning , Zhao Yiming , Smith Kirsten V. , Killikelly Clare , Stelzer Eva , Maercker Andreas , Xi Juzhe , Helm Peter J. 
Published: March 2023

AbstractObjectiveExistential isolation refers to an individual's awareness of the unbridgeable gulf between oneself, other people and the world. This kind of isolation has been found to be higher in individuals with nonnormative experiences, such as racial or sexual minorities. Bereaved individuals may experience a stronger sense of existential isolation and feel that no one shares their feelings or perceptions. However, research on bereaved people's experiences of existential isolation and its effects on post‐loss adaptation is scarce. This study aims to validate the German and Chinese versions of the Existential Isolation Scale, investigate cultural and gender differences in existential isolation and explore the associations between existential isolation and prolonged grief symptoms in German‐speaking and Chinese bereaved individuals.MethodsA cross‐sectional study with 267 Chinese and 158 German‐speaking bereaved participants was conducted. The participants completed self‐report questionnaires assessing existential isolation, prolonged grief symptoms, social networks, loneliness and social acknowledgement.ResultsThe results indicated that the German and Chinese versions of the Existential Isolation Scale demonstrated adequate validity and reliability. No cultural or gender differences (or their interaction) were found for existential isolation. Higher existential isolation was associated with elevated prolonged grief symptoms, which was further moderated by the cultural group. The relationship between existential isolation and prolonged grief symptoms was significant for the German‐speaking bereaved people but not significant for those from China.ConclusionThe findings highlight the role of existential isolation in the adaptation to bereavement and how different cultural backgrounds moderate the effect of existential isolation on post‐loss reactions. Theoretical and practical implications are discussed.
Design of novel compact eight‐element lotus shaped UWB‐MIMO antenna with triple‐notch characteristics on hollow substrate
Authors: Addepalli Tathababu , Manda Rajasekhar , Vidyavathi Thota , Babu Kamili Jagadeesh , Kumar Bandi Kiran 
Published: March 2023

SummaryThe design of novel compact two‐element and eight‐element lotus shaped multiple‐input‐multiple‐output (MIMO) antenna system employing pattern diversity with enhanced isolation characteristics is presented. The proposed two‐element antenna system is arranged rotationally on a square‐hollow substrate resulting in an eight‐element MIMO antenna system employing pattern diversity. The developed eight‐element MIMO antenna system resonates in the frequency range 3.1 to 14.6 GHz housing the complete UWB band with triple band‐notch characteristics at 3.7–4.5 GHz (C‐band satellite down link [3.7–4.2 GHz]), 5.1–5.9 GHz (WLAN) and 6.8–8.25 GHz (X‐band satellite down link (7.25–7.75 GHz) and up link (7.9–8.4 GHz)) bands. The antenna system gives element‐to‐element isolation of more than 25 dB in the majority of the operating band with a peak gain of 6.8 dBi and a maximum 90% efficiency. The important MIMO metrics like ECC (envelope correlation coefficient), DG (diversity gain), total active reflection coefficient (TARC), channel capacity losses (CCL) and MEG (mean effective gain) are presented for both two‐element and eight‐element to estimate the performance the proposed antennas in multi‐antenna environments. The both two‐ and eight‐element designs are fabricated and the measured results of those are well agreed with simulation results.
Infant negative affectivity and patterns of affect‐biased attention
Authors: Swales Danielle A. , Markant Julie , Hennessey Ella‐Marie P. , Glueck Deborah H. , Hankin Benjamin L. , Davis Elysia Poggi 
Published: March 2023

AbstractBiased attention toward affective cues often cooccurs with the emergence and maintenance of internalizing disorders. However, few studies have assessed whether affect‐biased attention in infancy relates to early indicators of psychopathological risk, such as negative affectivity. The current study evaluates whether negative affectivity relates to affect‐biased attention in 6‐month‐old infants. Affect‐biased attention was assessed via a free‐viewing eye‐tracking task in which infants were presented with a series of face pairs (comprised of a happy, angry, or sad face and a neutral face). Attention was quantified with metrics of both attention orienting and attention holding. Overall, infants showed no differences in attention orienting (i.e., speed of looking) or attention holding (i.e., duration of looking) toward emotional faces in comparison to the neutral face pairs. Negative affectivity, assessed via parent report, did not relate to attention orienting but was associated with biased attention toward positive, happy faces and away from threat‐cueing, angry faces in comparison to the neutral faces they were paired with. These findings suggest that negative affectivity is associated with differences in attention holding, but not initial orienting toward emotional faces; biases which have important implications for the trajectory of socioemotional development.
Advances in inutero electroporation
Authors: Kittock Claire M. , Pilaz Louis‐Jan 
Published: March 2023

Abstract
In utero electroporation (IUE) is a technique developed in the early 2000s to transfect the neurons and neural progenitors of embryonic brains, thus enabling continued development in utero and subsequent analyses of neural development. Early IUE experiments focused on ectopic expression of plasmid DNA to analyze parameters such as neuron morphology and migration. Recent advances made in other fields, such as CRISPR/CAS9 genome editing, have been incorporated into IUE techniques as they were developed. Here, we provide a general review of the mechanics and techniques involved in IUE and explore the breadth of approaches that can be used in conjunction with IUE to study cortical development in a rodent model, with a focus on the novel advances in IUE techniques. We also highlight a few cases that exemplify the potential of IUE to study a broad range of questions in neural development.
Trajectories and state changes of a grassland stream and riparian zone after a decade of woody vegetation removal
Authors: Dodds Walter K. , Ratajczak Zak , Keen Rachel M. , Nippert Jesse B. , Grudzinski Bartosz , Veach Allison , Taylor Jeffery H. , Kuhl Amanda 
Published: March 2023

AbstractRiparian zones and the streams they border provide vital habitat for organisms, water quality protection, and other important ecosystem services. These areas are under pressure from local (land use/land cover change) to global (climate change) processes. Woody vegetation is expanding in grassland riparian zones worldwide. Here we report on a decade‐long watershed‐scale mechanical removal of woody riparian vegetation along 4.5 km of stream channel in a before–after control impact experiment. Prior to this removal, woody plants had expanded into grassy riparian areas, associated with a decline in streamflow, loss of grassy plant species, and other ecosystem‐scale impacts. We confirmed some expected responses, including rapid increases in stream nutrients and sediments, disappearance of stream mosses, and decreased organic inputs to streams via riparian leaves. We were surprised that nutrient and sediment increases were transient for 3 years, that there was no recovery of stream discharge, and that areas with woody removal did not shift back to a grassland state, even when reseeded with grassland species. Rapid expansion of shrubs (Cornus drummondii, Prunus americana) in the areas where trees were removed allowed woody vegetation to remain dominant despite repeating the cutting every 2 years. Our results suggest woody expansion can fundamentally alter terrestrial and aquatic habitat connections in grasslands, resulting in inexorable movement toward a new ecosystem state. Human pressures, such as climate change, atmospheric CO2 increases, and elevated atmospheric nitrogen deposition, could continue to push the ecosystem along a trajectory that is difficult to change. Our results suggest that predicting relationships between riparian zones and the streams they border could be difficult in the face of global change in all biomes, even in well‐studied sites.
Emotional intelligence subdimensions as moderators in the association between body dissatisfaction and symptoms of eating disorders among female Mexican adolescents
Authors: Castro‐López Violeta R. , Franco‐Paredes Karina , Peláez‐Fernández María Angeles , Trujillo Chi Vacuán Eva María 
Published: March 2023

AbstractObjectiveStrong empirical research has shown a relationship between body dissatisfaction and symptoms of eating disorders (ED) and the direct and combined influence of emotional factors and dimensions of emotional intelligence (EI) on ED symptoms. However, whether these emotional variables and competencies moderate the well‐established relationship between body dissatisfaction and ED symptomatology has not yet been tested. Neither have studies of this nature been performed among high at‐risk populations such as Mexican female adolescents. Thus, this research aimed to explore the moderator role of EI subdimensions in the relationship between body dissatisfaction and ED symptoms among female adolescents from Sinaloa, Mexico.MethodsA total of 485 female adolescents aged 14–19 years old (M = 16.81, SD = 1.33) who were students in middle school, high school, and college completed questionnaires about body dissatisfaction, ED symptomatology, and EI. We conducted moderating analyses.ResultsSubdimensions of EI significantly moderated the relationship between body dissatisfaction and symptoms of ED. For participants high in body dissatisfaction, lower levels in stress management ability and higher levels in the interpersonal EI and Adaptability EI dimensions were associated with higher levels of ED symptomatology.DiscussionSubdimensions of EI have an important role in moderating the association between body dissatisfaction and symptoms of ED. The findings of this study contribute to improving the knowledge about the role of emotional competencies in ED. Proposals for future research and to improve preventative approaches are discussed.Public Significance StatementThis study shows the moderating role of EI dimensions in the well‐established relationship between body dissatisfaction and ED symptomatology. The research was conducted with a population at high risk of ED: female adolescents in the northwest of Mexico. Results showed that low Stress management EI, high Adaptability EI, and high Interpersonal EI were associated with higher levels of ED symptomatology among participants with high (but not low) body dissatisfaction. These insightful results have theoretical and practical implications.
Assessing non‐adjunctive CGM safety at home and in new markets (ANSHIN)
Authors: Chao Christy , Andrade Sarah B. , Bergford Simon , Calhoun Peter , Welsh John B. , Walker Tomas C. ,   ANSHIN Study Group
Published: March 2023

AbstractIntroductionContinuous glucose monitoring (CGM) can guide treatment for people with type 1 (T1D) and type 2 diabetes (T2D). The ANSHIN study assessed the impact of non‐adjunctive CGM use in adults with diabetes using intensive insulin therapy (IIT).Materials and MethodsThis single‐arm, prospective, interventional study enrolled adults with T1D or T2D who had not used CGM in the prior 6 months. Participants wore blinded CGMs (Dexcom G6) during a 20‐day run‐in phase, with treatment based on fingerstick glucose values, followed by a 16‐week intervention phase and then a randomized 12‐week extension phase with treatment based on CGM values. The primary outcome was change in HbA1c. Secondary outcomes were CGM metrics. Safety endpoints were the number of severe hypoglycaemic (SH) and diabetic ketoacidosis (DKA) events.ResultsOf the 77 adults enrolled, 63 completed the study. Those enrolled had mean (SD) baseline HbA1c of 9.8% (1.9%), 36% had T1D, and 44% were ≥65 years old. Mean HbA1c decreased by 1.3, 1.0 and 1.0 percentage points for participants with T1D, T2D or age ≥65, respectively (p < .001 for each). CGM‐based metrics including time in range also improved significantly. SH events decreased from the run‐in period (67.3 per 100 person‐years) to the intervention period (17.0 per 100 person‐years). Three DKA events unrelated to CGM use occurred during the total intervention period.ConclusionsNon‐adjunctive use of the Dexcom G6 CGM system improved glycaemic control and was safe for adults using IIT.