bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pharmacological Strategies for Bipolar Disorders in Acute Phases and
Chronic Management with a Special Focus on Lithium, Valproic Acid, and
Atypical Antipsychotics
Authors: Carli Marco , Weiss Francesco , Grenno Giovanna , Ponzini Sergio , Kolachalam Shivakumar , Vaglini Francesca , Viaggi Cristina , Pardini Carla , Tidona Simone , Longoni Biancamaria , Maggio Roberto , Scarselli Marco 
Published: February 2023

Abstract:
Bipolar disorders (BDs) are a heterogeneous group of severe affective disorders generally
described by the alternation of (hypo)manic, depressive, and mixed phases, with euthymic intervals of
variable duration. BDs are burdened with high psychiatric and physical comorbidity, increased suicide
risk and reduced life expectancy. In addition, BDs can progress into complicated forms (e.g., mixed
states, rapid/irregular cycling), which are more difficult to treat and often require personalized pharmacological
combinations. Mood stabilizers, particularly Lithium and Valproic acid (VPA), still represent
the cornerstones of both acute and chronic pharmacotherapies of BDs. Lithium is the gold
standard in BD-I and BDII with typical features, while VPA seems more effective for atypical forms
(e.g., mixed-prevalence and rapid-cycling). However, despite appropriate mood stabilization, many
patients show residual symptoms, and more than a half recur within 1-2 years, highlighting the need of
additional strategies. Among these, the association of atypical antipsychotics (AAPs) with mood stabilizers
is recurrent in the treatment of acute phases, but it is also being growingly explored in the
maintenance pharmacotherapy. These combinations are clinically more aggressive and often needed in
the acute phases, whereas simplifying pharmacotherapies to mood stabilizers only is preferable in the
long-term, whenever possible. When mood stabilizers are not enough for maintenance treatment,
Quetiapine and, less consistently, Aripiprazole have been proposed as the most advisable adjunctive
strategies, for their safety and tolerability profiles. However, in view of the increased risk of serious
adverse effects, a careful patient-centered balance between costs and benefits is mandatory.
Novel 2-pyridone Analogs with Anti-cancer Activity: Synthesis, In silico,
and In vitro Evaluation
Authors: Mishra Prem Shankar , Ravichandiran Velayutham , Mishra Rakhi 
Published: February 2023

Background:
2-pyridone is frequently used to synthesize and develop new bioactive molecules
approved for treating many diseases. The produced compounds play a significant role in inhibiting cancer
growth.

Objectives:
Through a molecular docking investigation, we determined the binding affinity of 2-pyridone
compounds with the Matrix Metalloproteinase receptor, which allowed us to develop, produce, and test
the in vitro anticancer efficacy of those compounds.

Method:
2-pyridones (A1-A12) were synthesized in a multistep process, followed by spectrum analysis
to confirm the structure. In silico screening of the synthesized compounds was carried out with the assistance
of AutoDock software. Flow cytometry was used on the HT-29 colon cancer cell line to measure
A1-A12’s anticancer effect in a lab setting.

Results:
The enzyme matrix metalloproteinase receptor and A1-A12 interacted unexpectedly during a
docking study (MMP3, MMP9 & MMP13). Research has shown a strong affinity for MMP3 receptors for
A9, A10, A11, A12, and A4, respectively. Further flow cytometric testing revealed compound A9 (R1) to
be highly cytotoxic, with an IC50 value of 20.77 M. The anticancer activity of A9 (R1) against HT-29
colon cancer cell lines was also confirmed by in vitro results.

Conclusion:
These findings suggested that 2-pyridone compounds have promising therapeutic potential
for cancer treatment, and more research on these lead moieties would be advantageous to discovering an
effective anticancer drug.
Achieving the “Double-Carbon” Goals in China-How May Research on
Consumer Food Preferences Help?
Authors: Chen Qihui , Wang Hongsha 
Published: February 2023

Abstract:
China announced the “Double Carbon” goals in 2020, aiming to achieve “Carbon
Peaking” by 2030 and “Carbon Neutrality” by 2060. Achieving these grand goals demands substantial
changes in China’s industrial system, the food industry included. Regarding the information
needed to formulate viable plans and policies at the industrial level to help achieve the
double-carbon goals, this article argues that research on the consumption side of the food industry
can be instrumental in informing industrial policy compatible with these goals. Specifically,
our discussion revolves around four questions. Why expect the food industry to play a significant
role in achieving the double-carbon goals? Why are consumers’ food preferences key to the design
of viable policy? What aspects of consumer preferences should be studied? Finally, how
may findings from such research be incorporated into food policy?
Pantoprazole-induced Stevens-Johnson Syndrome: A Case-report
Authors: Daldoul Mouna , Charfi Ons , Bouattour Emna , Hammami-Ghorbe Houda , Zaiem Ahmed , Fenniche Samy , Lakhoua Ghozlane , El Aidli Sihem 
Published: February 2023

Introduction:
Pantoprazole is a proton pump inhibitor mainly used to treat conditions
causing excess stomach acid. Stevens-Johnson syndrome (SJS) is a rare bullous disease. The main
etiologic factors are drugs, especially antibiotics, anticonvulsants, oxicam and allopurinol. Proton
pump inhibitors have been rarely reported as a causative agent in SJS, and only sporadic cases secondary
to pantoprazole have just been mentioned in the literature.

Case Report:
A 49-year-old woman was referred to the dermatology department for a pruritic generalized
eruption, associated with erosive cheilitis. The patient reported self-medication by pantoprazole
for two weeks. Physical examination revealed target-like lesions with bullous center in some
areas. A skin detachment on the left breast and the neck affecting 10% of the total body surface area
was observed. Mucosal examination revealed erosive, painful cheilitis covered by large hemorrhagic
crusts and erosions of the nasal cavity. The lesions cleared completely few days after pantoprazole
withdrawal and local corticosteroids. Further investigations ruled out infectious etiologies.

Conclusion:
This case highlights the possible occurrence of hypersensitivity reactions due to the
use of a PPI, which is a widely used medication and a generally well-tolerated drug.
Effects of Indigenous and Commercial Rhizobia on Growth and Nodulation of Soybean (Glycine max L) under Greenhouse Condition
Authors: Desta Mulugeta , Akuma Ayele , Minay Metadel , Yusuf Zekeria , Baye Kassa 
Published: February 2023

Background:Soybean (Glycine maxL.) is the most vital grain legume crop rich in protein and oil. The inoculation of rhizobia with soybean plays a very important role in increasing soil fertility via its contribution to biological nitrogen fixation.Objective:This study focuses on the evaluation of indigenous and commercial rhizobia on soybean nodulation and growth parameters.Methodology:Soil samples were collected from five districts for nodule trapping. The rhizobia were isolated using ‘plant induction following the standard procedures. The greenhouse experiments were arranged in a completed randomized design with three replications and two control units. The data were collected for plant height, nodule number, nodule dry weight, shoot dry weight, root length; root dry weight, total nitrogen and nitrogen-content.Results:The entire isolates were found gram-negative, without absorbing congo-red and did not grow on peptone glucose agar media. Slow grower isolates turned bromothymol blue with yeast extract mannitol agar medium into a moderately deep blue color but fast grower changed to yellow color. All isolates were tested on the sand induced nodule and were significantly superior to the negative control in terms of plant height, shoot dry weight, and nodule dry weight. The shoot dry weight of soybean rhizobial isolates on the sterilized sand experiment was ranging from 1.6 to 2.2g per plant and it was a highly significant correlation to the nodule number, nodule dry weight and root dry weight.Conclusion:The indigenous isolates were highly competent to all commercial rhizobia. This study encourages further evaluation of the field and molecular characteristics.
The Effects of Foliar Spray of Chitosan Nanoparticles on Tomato Resistance Against of Cuscuta Campestris Yunck
Authors: Moradkhani Sakineh , Jabbari Hadi 
Published: February 2023

Background:
Crop yield is limited by several factors. One of these factors is biotic stress. Among biotic stresses, parasitic plants have the greatest role in reducing plant growth and productivity. On the other hand, the multiple uses of pesticides and herbicides have a negative impact on the environment and agricultural products. As an eco-friendly compound, chitosan stimulates the defense system, increases plant resistance to biotic and abiotics stresses, and increases crop growth and productivity.

Methods:
In this study, the tomato plant was infected with Cuscuta campestris Yunck and sprayed with chitosan nanoparticles with a molecular weight of 50 kDa for 4 weeks and once a week. Four weeks after the infection, plants biomass, protein concentrations, antioxidant enzyme activity (SOD, CAT, APX, POD), and phenolic metabolism (PAL, PPO, total phenolic components, lignin) were measured.

Results:
In this study, chitosan application increased biomass in Dodder-infected and non-infected plants. The concentration of soluble proteins also increased. In Dodder-infected plants, the activity of antioxidant enzymes increased and the application of chitosan further increased the activity of these enzymes. Phenol metabolism as a defense mechanism in Dodder-infected plants increased compared to the control and chitosan application intensified phenol metabolism. SDS-PAGE analysis investigated that strong bands are formed in the range of 200 and 60 kDa in chitosan treatments and chitosan-treated infected plants.

Conclusion:
These bands were also observed in Dodder-infected plants that were not treated with chitosan.
Refractive and Topographic Parameters of the Belin/Ambrósio Module in Patients with Refractive Defects in Cuenca, Ecuador
Authors: Alvarez Eduardo Rojas , Alvarez Guachichulca Javier Santiago , Espinoza David Sebastián Chávez 
Published: February 2023

Objective:This study aimed to describe the refractive and topographic parameters of the Belin/Ambrósio module in patients with refractive defects at the Latino clinic in Cuenca, Ecuador, between 2017 to 2021.Methods:A descriptive, cross-sectional study was carried out. A database included anonymous cases of patients with refractive defects treated at the ophthalmological consultation of a Latino clinic from January, 2017 to June, 2021 was searched. Data was collected using a form containing study variables. Microsoft Excel and SPSS were used for data collection and analysis using frequencies, percentages, and measures of central tendency.Results:The sample consisted of 120 patients; 61.7% were women, and 38.3% were men. Moreover, 70.8% of patients were young adults. The pachymetry mean of the center of the pupil, apex, and position of lowest pachymetry was 521 µm, 520 µm, and 513 µm, respectively. The means of the flattest keratometry, curviest keratometry, and maximum keratometry were 43.30 D, 46.32 D, and 48.01 D, respectively.Conclusion:Cases distribution according to anterior and posterior elevation showed pathological values ​​in more than 50% of the studied corneas. According to the average progression index, pathological elevation was found in 18.8% of the cases, and according to the average deviations, 25.4% presented corneal ectasia in different stages.
Productivity Loss and Musculoskeletal Symptoms in Brazilian Presenteeism: A Cross-sectional Study
Authors: da Silva Santos Bruno , Bortolini Juliano , de Sousa Álvaro Francisco Lopes , Andrade Denise de , Valim Marília Duarte 
Published: February 2023

Background:
The work has been brought to nursing professionals, denoting an increase in illness and consequent decrease in productivity.

Objective:
This study aims to verify the relationship between productivity and the presence of musculoskeletal symptoms in presenteeism.

Methods:
This is a cross-sectional and analytical study conducted with 305 Nursing workers from an emergency hospital in the Brazilian Midwest region. For data collection, four self-applied instruments were used, namely: the Sociodemographic Work and Health Conditions Questionnaire (QSCTS), the Stanford Presenteeism Scale (SPS-6), the Work Limitations Questionnaire (WLQ), and the Brazilian version of the Nordic Musculoskeletal Questionnaire (NMQ), Nordic Musculoskeletal Symptom Questionnaire (QNSO). The “presenteeism” and “presenteeism degree” dependent variables were related to the independent variables using the logistic regression model.

Results:
Presenteeism was identified in 134 (43.8%) workers. Overall productivity loss was 8.8%. Regarding the relationship between presenteeism and the occurrence of musculoskeletal symptoms, workers with problems in the upper back, knees, and neck in the last year were 6.5, 2.7, and 2.2 more likely to be presenteeism, respectively.

Conclusion:
The study confirmed the relationship between greater productivity losses and the incidence of musculoskeletal symptoms with presenteeism events in the Nursing team.
Determinants of Parents’ Knowledge, Attitudes, and Practice toward Childhood Vaccination: A National Study
Authors: Nassar Omayah , Alshahwan Sandi , Alshahwan Rashed , Halasa Suhaila , Alashhab Shereen , Alnajar Malek 
Published: February 2023

Background:
Childhood vaccination is one of the World Health Organization's strategies to reduce vaccine-preventable diseases and children's mortality and morbidity rates. Adequate and accurate knowledge, as well as positive attitudes regarding vaccination, may increase parents’ compliance with their children’s vaccines.

Objective:
This study aimed to identify the determinants of parents’ knowledge, attitude, and practice toward childhood vaccination in Jordan.

Methods:
This is a descriptive cross-sectional study. The stratification method of sampling technique was used to split Jordan into three regions. The sample included 1477 participants. A total number of eleven Maternal and Child Health Care centers were selected as the study’s site.

Results:
Results showed that parents have sufficient knowledge regarding the importance of vaccines in maintaining a child’s health, with a mean percentage of correctly answered questions of 78.7%. However, they have inadequate knowledge regarding the adverse reactions (57.5%) and the contraindications of vaccines (61.8%). Parents had positive attitudes regarding the National Immunization Program where 97% agreed with it. However, 83% of parents had negative attitudes toward vaccine safety. Parents’ work, residency, income, and age are significant determinants of parents’ attitudes, knowledge, and practice regarding children's vaccines.

Conclusion:
The study may motivate nurses to implement more educational interventions regarding children’s vaccination to upgrade parents' knowledge with particular emphasis on parents with a low level of education and the residents of rural areas.
Damage Identification in Plane Multi-storey Reinforced Concrete Frame
Authors: Makarios Triantafyllos K. 
Published: February 2023

Objective:
In this paper, a new method for damage detection in reinforced concrete multi-storey frames is presented.

Methods:
The proposed new methodology is a hybrid technique consisting of two parts. The first step involves determining the seismic pushover capacity curve of the structure, and the second step includes formulating the diagram of the instantaneous eigenfequencies of the structure in the nonlinear regime. With reference to this diagram, more details are given in the text. To estimate the equivalent target displacement defined at the top of the structure, which corresponds to the instantaneous eigenfrequencies of a structure with damage, the diagram of these eigenfrequencies is combined with the seismic pushover capacity curve of the structure. Thus, the target displacement at the top of the frame is calculated.

Result:
The advantage of the proposed methodology is that using this target displacement, the final picture of the damage in the structure is estimated from the two pushover analyses, with positive and negative signs of the floor lateral forces corresponding to triangular distribution in elevation. For clarification, an example of a three-storey R/C frame is presented as a paradigm.

Conclusion:
Using the proposed methodology, the locations of damage in the structure are successfully identified, as well as the Damage Stiffness Matrix is estimated with high accuracy.
Characterization of a Haloalkaline Nocardiopsis sp. Strain S10 Isolated
from Wastewater and Optimization of Culture Medium for Improving
Production of Antifungal Compounds
Authors: Souagui Samiha , Boudries Hafid , Djoudi Warda , Djinni Ibtissem , Laincer Firdousse , Keramane Badria , Kecha Mouloud 
Published: February 2023

Background:
The emerging antibiotic resistant bacteria (ARB) and antibiotic resistance
genes (ARGs) are a pressing global concern. Furthermore, the limited number of available
antifungal agents requires the discovery of new antimicrobials.

Introduction:
This paper focused on the isolation and characterization of an actinobacterium designated
S10, the study of its antimicrobial activity, on the one hand, and the optimization of antifungal
production using statistical methods, on the other hand.

Methods and Results:
A haloalkaliphilic actinobacterium designated S10 was isolated from a
wastewater treatment plant in the Souk-El-Tenine region (Bejaia, Algeria). This strain showed a
broad spectrum of activity against bacteria (B. subtilis, L. innocua, M. luteus, S. aureus, MRSA,
E. coli, P. aeruginosa, S. Typhi, and V. cholerae), molds (A. niger, G. geotricum, and F. oxysporum)
and a pathogenic yeast (C. albicans). The extracellular enzymes producer Nocardiopsis
sp. S10 was identified based on morphological, chemical, and 16S rRNA gene sequencing analysis.
The best antimicrobial production was achieved on Mincer-Sea-Water (MSW) solid medium,
and the antibiotics produced were extracted with ethyl acetate. For antifungal production, central
composite design (CCD) and response surface methodology (RSM) were used to optimize the
culture medium formulation.

Conclusion:
Optimal antifungal activity was achieved using a mixture of 2 g. L-1 starch, 2 g. L-1
of yeast extract and 2.75 g. L-1 of peptone at pH = 9.2. The application of the statistical approach
stimulated a good yield of anti-C. albicans activity, corresponding to an increase of 72.22% compared
to the non-optimized conditions.
Oral Disintegrating Tablets of Proton Pump Inhibitors for Chronic Gastroesophageal
Reflux Disease: An Update
Authors: Gupta Avani , Akhtar Juber , Rastogi KC , Badruddeen  , Khan Mohammad Irfan , Ahmad Mohammad 
Published: February 2023

Abstract:
Oral disintegrating tablets (ODT) offer an attractive choice for Gastroesophageal Reflux
Disease (GERD) patients suffering from dysphagia. In chronic condition, GERD patient suffers
from severe erosive esophagitis. Thus patients feel difficulty and pain during swallowing,
which results in patient in-compliance toward medication of tablets or capsules- especially in geriatrics
and pediatric patients. These symptoms of GERD patients have attracted the formulation
scientists in improving the formulation methodology for such patients. Orally disintegrating tablets
could increase the therapeutic impact and drug compliance in these patients. The aim of this
compilation is to provide a more convenient way to develop an oral disintegrating drug delivery
system of proton pump inhibitors in patients suffering from odynophagia, associated with chronic
Gastroesophageal Reflux Disease (GERD). Oral disintegrating tablets (ODT), when placed on the
tongue, can quickly disintegrate and release the medicament. It later dissolves or disperses in saliva
without any additional water. The saliva containing drug can easily be swallowed and descends
into the stomach leading to maximum absorption from the mouth, throat, and upper esophagus.
The patient compliance and bio-availability of Oral disintegrating tablets (ODT) are high compared
to other conventional tablets.
Influence of Internet-Based Health Management on Control of Clinical Parameters in Patients With Hypertension: Four-Year Longitudinal Study
Authors: Chen Botian , Dou Yuqi , Yu Xue , Ma Defu 
Published: February 2023

Background
In recent years, more and more studies have shown that internet-based health management can help patients with hypertension control their blood pressure. However, there is a lack of similar research in China.

Objective
We designed this study to clarify the impact of long-term internet-based health management on the control of clinical parameters in patients with hypertension. These results are also expected to identify the relevant factors affecting the control of clinical parameters in hypertension more accurately toward developing more targeted health management strategies.

Methods
This was a longitudinal study of internet-based health management in the five provinces of northwest China. The inclusion criteria were aged ≥18 years and no serious cognitive disease or mental disorder. After collecting the physical examination data of 8567 people in the five northwest provinces in 2013, we conducted online health management (including diet, exercise, and behavior) and follow-up. In the physical examination in 2013, 1008 new patients with hypertension were identified, who were divided into a good blood pressure control group and poor blood pressure control group. Physical examination and a questionnaire survey were conducted every 2 years to understand the changes of health management on the subjects’ health-related behaviors. We then analyzed the changes of clinical indicators related to hypertension and the influencing factors related to blood pressure control in patients with hypertension. All statistical analyses were performed using R software (version 4.1.2) and a P value <.05 was considered statistically significant.

Results
A total of 8567 people met the inclusion criteria and underwent health management. Self-comparison showed that after 4 years of health management, the smoking cessation rate and amount of exercise significantly increased (both P<.001). The low-density lipoprotein-cholesterol levels also increased (P=.005), whereas the high-density lipoprotein-cholesterol levels decreased (P=.007). The newly discovered patients with hypertension in 2013 were further screened. After 4 years of health management, their smoking cessation rate increased significantly (P=.03) and the amount of exercise increased but not significantly (P=.08). In terms of clinical indicators, the diastolic blood pressure considerably decreased (P<.001) and the systolic blood pressure slightly decreased (P=.13). The correlation analysis of blood pressure control in patients with new-onset hypertension showed that gender (female) and changing relevant factors according to health management behaviors (BMI; cereals and potatoes intake; fish, livestock meat, and eggs intake; fruit intake; and physical activity) were the protective factors of blood pressure control.

Conclusions
Internet-based health management has a significant and long-term effect on blood pressure control in patients with hypertension.