bluuebunny/crossref_metadata_2025_split huggingface dataset:
Aducanumab: an uprising hope with vague horizons
Authors: Hazegh Fetratjoo Delara , Kargar Alireza , Noroozian Maryam 
Published: June 2023

AbstractAlzheimer’s disease (AD) is the leading cause of dementia worldwide. Amyloid-beta (Aβ) deposition, is one of the processes involved in the pathophysiology of AD, has inspired interest in targeted therapies, including monoclonal antibodies. Aducanumab acts as a fully human IgG1 monoclonal antibody against Aβ by binding to amyloid plaques and was approved by the Food and Drug Administration (FDA) as the first disease-modifying drug for mild cognitive impairment and mild stages of AD. This accelerated approval, albeit the termination of the two phase III clinical trials of aducanumab due to results of futility analysis, has provoked controversy among the key opinion leaders in the field of cognitive neurology. Aducanumab poses significant financial constraints on patients and healthcare systems. Furthermore, the precise diagnosis of AD stages for appropriate aducanumab initiation remains a formidable challenge. The drug’s administration necessitates specialized infrastructure and medical equipment, and it may induce amyloid-related imaging abnormalities (ARIA), potentially resulting in cerebral edema or hemorrhage. These disadvantages might outweigh the potential benefits of the medication, especially considering the uncertainties regarding its efficacy. This commentary is intended to briefly evaluate the application of aducanumab in developing countries, considering the associated diagnostic challenges, clinical efficacy, cost, and potential adverse effects.
Author response to "Absence of proximal muscle weakness, dysarthria, and facial diplegia suggest Guillain–Barre syndrome rather than CIDP"
Authors: Tsiptsios Dimitrios , Fotiadou Aggeliki , Karatzetzou Stella , Kitmeridou Sofia , Iliopoulos Ioannis 
Published: June 2023

AbstractIn many instances, the differential diagnosis between Guillain–Barre syndrome and chronic inflammatory demyelinating polyneuropathy (CIDP) may be challenging. The aim of this letter to the editor is to elucidate comments and concerns raised, regarding our latest published article dealing with two patients that developed acute-onset CIDP after SARS-CoV-2 infection and Ad26.COV2.S vaccination, respectively.
Supplementation of rapamycin during in vitro maturation promotes oocyte quality and subsequent embryo development in bovine
Authors: Khatun Hafiza , Islam Md Rasadul , Khan Muckta , Sultana Fowzia 
Published: June 2023

Abstract
Background
The developmental competence of oocyte derived from in vitro maturation (IVM) is significantly lower than those of oocyte matured in vivo. Rapamycin is an immunosuppressive substance and widely used to prolong the survival and preserve the cells culture. The objective of this research was to explore whether rapamycin supplementation during IVM enhances meiotic maturation, oocyte quality, and subsequent embryonic development.

Methods
Depending on the purpose, bovine cumulus oocyte complexes were matured without (control) or with rapamycin at different concentrations (0, 1, 10, and 100 nM) for 22 h (h) followed by 6 h in vitro fertilization, and zygotes were cultured for 8 days. Following treatment, oocytes developmental competence was assessed by meiotic progression, intra-oocyte GSH synthesis, reactive oxygen species (ROS) levels, and subsequent embryonic development.

Results
The results showed that addition of 1 nM rapamycin to IVM medium significantly increased the nuclear maturation (90.1 ± 1.5 vs. 81.2 ± 2.5; P < 0.01) and subsequent embryonic development (47.6 ± 2.2 vs. 41.5 ± 1.9; P < 0.05) than that observed in the control group. Consequently, compared to the control group, the relative fluorescence’s intensity of ROS levels in oocyte significantly reduced by rapamycin treatment. More importantly, rapamycin supplementation during maturation significantly increased the reduced glutathione synthesis levels in oocyte compared to that observed in control, indicating the bidirectional communication between cumulus cells and oocyte becomes easy via rapamycin treatment.

Conclusions
This study suggests that the presence of rapamycin during maturation can afford to enhance reduced glutathione synthesized by the oocyte, which is an internal oocyte antioxidant defense and contributes to improve subsequent high-quality embryo production.
The microbiota knows: handling-stress and diet transform the microbial landscape in the gut content of rainbow trout in RAS
Authors: Suhr Marvin , Fichtner-Grabowski Finn-Thorbjörn , Seibel Henrike , Bang Corinna , Franke Andre , Schulz Carsten , Hornburg Stéphanie Céline 
Published: June 2023

Abstract
Background
The aim of the present study was to characterize the effects of handling stress on the microbiota in the intestinal gut contents of rainbow trout (Oncorhynchus mykiss) fed a plant-based diet from two different breeding lines (initial body weights: A: 124.69 g, B: 147.24 g). Diets were formulated in accordance with commercial trout diets differing in their respective protein sources: fishmeal (35% in fishmeal-based diet F, 7% in plant protein-based diet V) and plant-based proteins (47% in diet F, 73% in diet V). Experimental diets were provided for 59 days to all female trout in two separate recirculating aquaculture systems (RASs; mean temperature: A: 15.17 °C ± 0.44, B: 15.42 °C ± 0.38). Half of the fish in each RAS were chased with a fishing net twice per day to induce long-term stress (Group 1), while the other half were not exposed to stress (Group 0).

Results
No differences in performance parameters were found between the treatment groups. By using 16S rRNA amplicon sequencing of the hypervariable region V3/V4, we examined the microbial community in the whole intestinal content of fish at the end of the trial. We discovered no significant differences in alpha diversity induced by diet or stress within either genetic trout line. However, the microbial composition was significantly driven by the interaction of stress and diet in trout line A. Otherwise, in trout line B, the main factor was stress. The communities of both breeding lines were predominantly colonized by bacteria from the phyla Fusobacteriota, Firmicutes, Proteobacteria, Actinobacteriota, and Bacteroidota. The most varying and abundant taxa were Firmicutes and Fusobacteriota, whereas at the genus level, Cetobacterium and Mycoplasma were key components in terms of adaptation. In trout line A, Cetobacterium abundance was affected by factor stress, and in trout line B, it was affected by the factor diet.

Conclusion
We conclude that microbial gut composition, but neither microbial diversity nor fish performance, is highly influenced by stress handling, which also interacts with dietary protein sources. This influence varies between different genetic trout lines and depends on the fish’s life history.
Dynamic interplay between available resources and implementation climate across phases of implementation: a qualitative study of a VA national population health tool
Authors: Lin Ying-Jen , Ranusch Allison , Seagull F. Jacob , Sussman Jeremy B. , Barnes Geoffrey D. 
Published: June 2023

Abstract
Background
Available resources within an organization can determine the implementation success of an intervention. However, few studies have investigated how the required resources change over the phases of implementation. Using stakeholder interviews, we examined the changes in and interactions between available resources and implementation climate in the implementation and sustainment phases of a national implementation effort for a population health tool.

Methods
We conducted a secondary analysis of the interviews with 20 anticoagulation professionals at 17 clinical sites in the Veterans Health Administration health system about their experiences with a population health dashboard for anticoagulant management. Interview transcripts were coded using constructs from the Consolidated Framework for Implementation Research (CFIR) and according to the phase of implementation (pre-implementation, implementation, and sustainment) as defined by the VA Quality Enhancement Research Initiative (QUERI) Roadmap. We analyzed the factors that may determine successful implementation by examining the co-occurrence patterns between available resources and implementation climate across different implementation phases. To illustrate the variations in these determinants across phases, we aggregated and scored coded statements using a previously published CFIR scoring system (− 2 to + 2). Key relationships between available resources and implementation climate were identified and summarized using thematic analysis.

Results
The resources necessary to support the successful implementation of an intervention are not static; both the quantity and types of resources shift based on the phases of the intervention. Furthermore, increased resource availability does not guarantee the sustainment of intervention success. Users need different types of support beyond the technical aspects of an intervention, and this support varies over time. Specifically, available resources in the form of technological support and social/emotional support help users establish trust in a new technological-based intervention during the implementation phase. Resources that foster and maintain collaboration between users and other stakeholders help them stay motivated during sustainment.

Conclusions
Our findings highlight the dynamic nature of available resources and their impacts on the implementation climate across different phases of implementation. A better understanding of the dynamics of available resources over time from the users’ perspectives will allow the adaptation of resources to better meet the needs of the intervention stakeholders.
Cerebral dominance in spatial hearing and working memory abilities in adults with normal hearing sensitivity
Authors: Banumathi  , Nethra R , Raj Brunda L. , Nisha Kavassery Venkateswaran 
Published: June 2023

Abstract
Background
Cerebral dominance refers to the biological description of the brain, where one cerebral hemisphere is dominant over the other in certain cerebral functions. There is scanty literature on cerebral dominance and its impact on auditory spatial processing and working memory, which is explored in the study.

Methods
A total of 45 participants with normal hearing were divided into three groups of 15 participants. The groups were categorized based on scores obtained on the alert scale of the cognitive style checklist as the bilateral dominant, left dominant, and the right dominant group. The spatial hearing was assessed using interaural time difference (ITD), the interaural level difference (ILD), and virtual acoustic space identification (VASI) tests, whereas the auditory working memory abilities were tested using forward span, backward span, ascending digit span, descending digit span, and 2n back tests.

Results
MONOVA results indicated that there is no significant main effect of cerebral dominance on all auditory working memory tests. In spatial hearing, although ILD and ILD thresholds were not influenced by cerebral dominance, the main effect of cerebral dominance was seen on VASI accuracy scores. Post-hoc analyses of VASI scores showed that the bilateral dominant group demonstrated significantly better spatial perception scores compared to the left and right dominant groups, with latter groups showing similar performance.

Conclusions
While ITD and ILD tests fall short of revealing cerebral asymmetry, VASI’s power in capturing cerebral dominance effects makes it a valuable tool in spatial processing assessment. The study’s findings highlight the need for assessing cerebral dominance, before administering spatial hearing tests.
Case Report: Tuberculosis lymphadenitis with systemic lupus erythematosus in a young woman: a case report
Authors: Arliny Yunita , Yanifitri Dewi Behtri , Utami Wilia Aprilisa , Geraldine Samantha 
Published: June 2023

Background: Tuberculosis is a chronic infectious disease and can be categorised into pulmonary TB and extra-pulmonary TB based on its spread. TB lymphadenitis is one of the extra-pulmonary TB diseases. Patients with a weakened immune system in systemic lupus erythematosus (SLE) have an increased incidence of TB. Case: Here we present a case report of a 21-year-old female patient with SLE diagnosed with tuberculous lymphadenitis at dr. Zainoel Abidin Hospital, Banda Aceh, Indonesia. The patient complained of a lump in the right neck 4 months ago with a diameter of 4 cm, accompanied by fever, decreased appetite, and weight loss. Other than that, the patient also experiences joint pain, hair loss and sun sensitivity since 12 months ago. Chest radiography showed no abnormalities, and fine-needle aspiration biopsy results confirmed tuberculous lymphadenitis. Antinuclear antibody test was borderline. The patient had been taking steroids and hydroxychloroquine for the past 10 months. Currently, the patient is taking the advanced phase of antituberculosis drugs FDC. After undergoing the intensive phase of antituberculosis drugs, the submandibular lump got smaller to a diameter of 2 cm. Conclusion: TB lymphadenitis is a rare case but can occur in conditions of decreased immunity like SLE. It involves some of the immune disorders caused by the long-term use of immunosuppressive therapy.
Health-seeking behaviours of pregnant adolescents: a scoping review
Authors: Khuzaiyah Siti , Mumin Khadizah Hj Abdul , McKenna Lisa , Hashim Sarena Hj 
Published: June 2023

Background/AimsAdolescent pregnancy has become a global concern because of its potential impact on health and childbirth, as well as its socioeconomic and psychological consequences. The aim of this study was to investigate pregnant adolescents' experiences seeking healthcare, to identify factors influencing their use of maternal healthcare services.MethodsA scoping review for articles published in the last 10 years from six databases was conducted. A total of 25 studies that described pregnant adolescents' health-seeking behaviour during pregnancy and childbirth were included.ResultsThe majority of studies were conducted in Africa and most aimed to assess factors influencing health-seeking behaviours and use of antenatal care among pregnant adolescents. Ten studies used behavioural change theories and models. Several enabling factors and barriers influencing behaviour were identified.ConclusionsAdolescents, families, communities and healthcare providers should work together to promote health-seeking behaviours among pregnant adolescents. Midwives should encourage pregnant adolescents to visit healthcare centres and provide positive antenatal care experiences.
Can extended duties dental nurses (EDDNs) as oral health educators (OHEs) be beneficial for the practice and morale?
Authors: Dawson Jo 
Published: June 2023

Jo Dawson explores what it is like to use the Oral Health Education qualification in a general dental practice setting and the empowering opportunities it can offer patients and staff. Aim To have a better understanding of the advantages of using EDDN OHEs in general dental practice. Objectives To have an increased awareness of the role of an oral health educator. To understand what benefits offering an OHE service could bring to a dental practice. To look at examples using EDDN OHEs and the impact they have had on Dental Nurse's self-esteem and their standing within the practice team.
Combined evaluation of Geriatric nutritional risk index and Neutrophil to lymphocyte ratio for predicting all-cause and cardiovascular mortality in hemodialysis patients
Authors: Wang Jun , Huang Li-juan , Li Bei , Xu Mei-chang , Yang Lei , Deng Xu , Li Xin 
Published: June 2023

Objective
Malnutrition, accompanied by an inflammatory profile, is a risk factor for poor prognosis in hemodialysis patients. The purpose of this study was to investigate the predictive value of NLR combined with GNRI for all-cause and cardiovascular mortality in hemodialysis patients.

Methods
A total of 240 maintenance hemodialysis (MHD) patients in hemodialysis centers were enrolled in this retrospective study. The influencing factors of all-cause death in hemodialysis patients were analyzed by COX regression. The cut-off values of GNRI and NLR for predicting mortality in enrolled MHD patients were 89.01 and 4, respectively. Based on these cut-off values, the patients were divided into four groups: G1: high GNRI (≥ 89.01) + high NLR (≥ 4) group; G2: high GNRI (≥ 89.01) + low NLR (<4) group, G3: low GNRI (< 89.01) + high NLR (≥4) group; G4: low GNRI (< 89.01) + low NLR (<4).

Results
During the follow-up period (average: 58 months), the all-cause mortality was 20.83%(50/240) and the cardiovascular mortality was 12.08%(29/240). Both NLR and GNRI were independent risk factors for the prognosis of MHD patients (P<0.05). Survival analysis showed that patients with low GNRI had a lower survival rate than those with high GNRI, whereas patients with high NLR had a lower survival rate than those with low NLR. Kaplan-Meier curve for all-cause mortality revealed that compared to G1, G2, and G4, G3 had the lowest survival rate, while G2 had the highest survival rate among all groups (P < 0.05). Kaplan-Meier curve for cardiovascular mortality showed that G3 had lower survival than G1, G2, and G4 (P < 0.001).

Conclusions
Our study demonstrates that bothGNRI and NLR are associated with all-cause mortality and cardiovascular mortality in MHD patients. Combining these two factorsmay contribute to a prognostic evaluation for MHD patients.
Cytomegalovirus in donors for fecal microbiota transplantation, the phantom menace?
Authors: Galpérine Tatiana , Engelmann Ilka , Hantz Sebastien , Postil Déborah , Dewilde Anny , Deplanque Dominique , Martin Renaud , Labreuche Julien , Lazrek Mouna , Somers Stéphanie , Ribot Elodie , Alain Sophie 
Published: June 2023

BackgroundFecal Microbiota Transplantation (FMT) has become the preferred treatment for recurrentClostridioides difficileInfections (CDI). However, donor screening is a complex process that varies between countries. The primary objective of screening is to prevent the transfer of potential pathogens from the donor to the recipient via feces. Many guidelines recommend Cytomegalovirus (CMV) testing as part of donor screening, but is the risk of CMV transmission well supported by evidence?Materials/methodsA French prospective cross-sectional multicenter single-arm study estimated the frequency of detection of CMV in the stool of voluntary healthy donors selected for FMT. All preselected donors were tested for CMV antibodies in blood, and if positive, CMV DNA PCR was performed on whole blood and stool. For samples CMV positive in stool PCR, or case of serological markers positive for IgM, we planned isolation of CMV in cell culture.ResultsFrom June 1, 2016, to July 31, 2017, 500 healthy donors (250 per center) were recruited and 483 included. Of these, 301 were CMV seronegative, and 182 tested positive for CMV IgM and/or IgG. Stool CMV PCR was performed in 162 donors. In two cases, the initial analysis was positive, but below the limit of quantification. Repeated PCR tests using Siemens and Altostar assays were negative. No infectious CMV could be detected in cell culture of these two samples and in the stool of 6 CMV IgM-positive donors.ConclusionsOur study shows that healthy volunteers with positive CMV serology do not shed CMV DNA in their stool, as detected by PCR or cell culture. This study provides another argument to remove CMV screening for FMT donors.
Impacts of antipsychotic medication prescribing practices in critically ill adult patients on health resource utilization and new psychoactive medication prescriptions
Authors: Jaworska Natalia , Soo Andrea , Stelfox Henry T. , Burry Lisa D. , Fiest Kirsten M. 
Published: June 2023

Background
Antipsychotic medications are commonly prescribed to critically ill adult patients and initiation of new antipsychotic prescriptions in the intensive care unit (ICU) increases the proportion of patients discharged home on antipsychotics. Critically ill adult patients are also frequently exposed to multiple psychoactive medications during ICU admission and hospitalization including benzodiazepines and opioid medications which may increase the risk of psychoactive polypharmacy following hospital discharge. The associated impact on health resource utilization and risk of new benzodiazepine and opioid prescriptions is unknown.

Research question
What is the burden of health resource utilization and odds of new prescriptions of benzodiazepines and opioids up to 1-year post-hospital discharge in critically ill patients with new antipsychotic prescriptions at hospital discharge?

Study design & methods
We completed a multi-center, propensity-score matched retrospective cohort study of critically ill adult patients. The primary exposure was administration of ≥1 dose of an antipsychotic while the patient was admitted in the ICU and ward with continuation at hospital discharge and a filled outpatient prescription within 1-year following hospital discharge. The control group was defined as no doses of antipsychotics administered in the ICU and hospital ward and no filled outpatient prescriptions for antipsychotics within 1-year following hospital discharge. The primary outcome was health resource utilization (72-hour ICU readmission, 30-day hospital readmission, 30-day emergency room visitation, 30-day mortality). Secondary outcomes were administration of benzodiazepines and/or opioids in-hospital and following hospital discharge in patients receiving antipsychotics.

Results
1,388 propensity-score matched patients were included who did and did not receive antipsychotics in ICU and survived to hospital discharge. New antipsychotic prescriptions were not associated with increased health resource utilization or 30-day mortality following hospital discharge. There was increased odds of new prescriptions of benzodiazepines (adjusted odds ratio [aOR] 1.61 [95%CI 1.19–2.19]) and opioids (aOR 1.82 [95%CI 1.38–2.40]) up to 1-year following hospital discharge in patients continuing antipsychotics at hospital discharge.

Interpretation
New antipsychotic prescriptions at hospital discharge are significantly associated with additional prescriptions of benzodiazepines and opioids in-hospital and up to 1-year following hospital discharge.
Some results on fractional Hahn difference boundary value problems
Authors: Baheeg Elsaddam A. , Oraby Karima M. , Akel Mohamed S. 
Published: June 2023

Abstract
Fractional Hahn boundary value problems are significant tools to describe mathematical and physical phenomena depending on non-differentiable functions. In this work, we develop certain aspects of the theory of fractional Hahn boundary value problems involving fractional Hahn derivatives of the Caputo type. First, we construct the Green function for an

α
th

\alpha {\rm{th}}

-order fractional boundary value problem, with

1
<
α
<
2

1\lt \alpha \lt 2

, and discuss some important properties of the Green function. The solutions to the proposed problems are obtained in terms of the Green function. The uniqueness of the solutions is proved by various fixed point theorems. The Banach’s contraction mapping theorem, the Schauder’s theorem, and the Browder’s theorem are used.