bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pericytes protect rats and mice from sepsis-induced injuries by maintaining vascular reactivity and barrier function: implication of miRNAs and microvesicles
Authors: Zhang Zi-Sen , Liu Yi-Yan , He Shuang-Shuang , Bao Dai-Qin , Wang Hong-Chen , Zhang Jie , Peng Xiao-Yong , Zang Jia-Tao , Zhu Yu , Wu Yue , Li Qing-Hui , Li Tao , Liu Liang-Ming 
Published: March 2023

Abstract
Background
Vascular hyporeactivity and leakage are key pathophysiologic features that produce multi-organ damage upon sepsis. We hypothesized that pericytes, a group of pluripotent cells that maintain vascular integrity and tension, are protective against sepsis via regulating vascular reactivity and permeability.

Methods
We conducted a series of in vivo experiments using wild-type (WT), platelet-derived growth factor receptor beta (PDGFR-β)-Cre + mT/mG transgenic mice and Tie2-Cre + Cx43flox/flox mice to examine the relative contribution of pericytes in sepsis, either induced by cecal ligation and puncture (CLP) or lipopolysaccharide (LPS) challenge. In a separate set of experiments with Sprague–Dawley (SD) rats, pericytes were depleted using CP-673451, a selective PDGFR-β inhibitor, at a dosage of 40 mg/(kg·d) for 7 consecutive days. Cultured pericytes, vascular endothelial cells (VECs) and vascular smooth muscle cells (VSMCs) were used for mechanistic investigations. The effects of pericytes and pericyte-derived microvesicles (PCMVs) and candidate miRNAs on vascular reactivity and barrier function were also examined.

Results
CLP and LPS induced severe injury/loss of pericytes, vascular hyporeactivity and leakage (P < 0.05). Transplantation with exogenous pericytes protected vascular reactivity and barrier function via microvessel colonization (P < 0.05). Cx43 knockout in either pericytes or VECs reduced pericyte colonization in microvessels (P < 0.05). Additionally, PCMVs transferred miR-145 and miR-132 to VSMCs and VECs, respectively, exerting a protective effect on vascular reactivity and barrier function after sepsis (P < 0.05). miR-145 primarily improved the contractile response of VSMCs by activating the sphingosine kinase 2 (Sphk2)/sphingosine-1-phosphate receptor (S1PR)1/phosphorylation of myosin light chain 20 pathway, whereas miR-132 effectively improved the barrier function of VECs by activating the Sphk2/S1PR2/zonula occludens-1 and vascular endothelial-cadherin pathways.

Conclusions
Pericytes are protective against sepsis through regulating vascular reactivity and barrier function. Possible mechanisms include both direct colonization of microvasculature and secretion of PCMVs.
Acute malnutrition recovery rates improve with COVID-19 adapted nutrition treatment protocols in South Sudan: a mixed methods study
Authors: Lyles Emily , Banks Sandra , Ramaswamy Maya , Ismail Sule , Leidman Eva , Doocy Shannon 
Published: March 2023

Abstract
Background
Globally, emergency nutrition program adaptations were implemented as part of COVID-19 mitigation strategies, but the implications of the adoption of all protocol changes at scale in the context of deteriorating food security are not yet well characterized. With ongoing conflict, widespread floods, and declining food security, the secondary impacts of COVID-19 on child survival in South Sudan is of great concern. In light of this, the present study aimed to characterize the impact of COVID-19 on nutrition programming in South Sudan.

Methods
A mixed methods approach including a desk review and secondary analysis of facility-level program data was used to analyze trends in program indicators over time and compare two 15-month periods prior to the onset of COVID-19 (January 2019 – March 2020; “pre-COVID period”) and after the start of the pandemic (April 2020 – June 2021; “COVID” period) in South Sudan.

Results
The median number of reporting Community Management of Acute Malnutrition sites increased from 1167 pre-COVID to 1189 during COVID. Admission trends followed historic seasonal patterns in South Sudan; however, compared to pre-COVID, declines were seen during COVID in total admissions (− 8.2%) and median monthly admissions (− 21.8%) for severe acute malnutrition. For moderate acute malnutrition, total admissions increased slightly during COVID (1.1%) while median monthly admissions declined (− 6.7%). Median monthly recovery rates improved for severe (92.0% pre-COVID to 95.7% during COVID) and moderate acute malnutrition (91.5 to 94.3%) with improvements also seen in all states. At the national level, rates also decreased for default (− 2.4% for severe, − 1.7% for moderate acute malnutrition) and non-recovery (− 0.9% for severe, − 1.1% for moderate acute malnutrition), with mortality rates remaining constant at 0.05–0.15%.

Conclusions
Within the context of the ongoing COVID-19 pandemic in South Sudan, improved recovery, default, and non-responder rates were observed following adoption of changes to nutrition protocols. Policymakers in South Sudan and other resource-constrained settings should consider if simplified nutrition treatment protocols adopted during COVID-19 improved performance and should be maintained in lieu of reverting to standard treatment protocols.
A new neutron-gamma porosity measurement method for pulsed neutron logging tools
Authors: Fu Xinyue , Wu Wensheng , Wang Hu , Ge Yunlong 
Published: March 2023

As an alternative method for the compensated neutron porosity measurement method, the neutron-gamma porosity measurement method is widely used in cased holes. However, the neutron-gamma porosity measurement method has some problems, such as the lack of detailed theoretical analysis and low sensitivity in high-porosity formations. The purpose of this paper is to clarify the theory of neutron-gamma porosity measurement, improve the measurement sensitivity, and eliminate the effects of environmental factors. Based on the neutron diffusion theory and the gamma transport theory, the distribution of capture gamma rays is described. A new neutron-gamma porosity measurement method is developed based on inelastic and capture gamma-ray distribution. The applicability of the new method in different environments is analyzed using the Monte Carlo method, and the effectiveness of this method is verified using the synthetic model. The results indicate that the capture gamma-ray ratio is only related to the source-detector distance, gamma-ray attenuation length, and neutron migration length. By combining density, different neutron cross sections, inelastic gamma-ray count ratio, and capture gamma-ray count ratio, the parameter secondary gamma-ray hydrogen index (SGH) related to hydrogen index can be extracted. The dynamic range of SGH is much higher than thermal neutron count ratio and the capture gamma-ray count ratio. The errors in porosity calculation by this method under different borehole and lithologic conditions are generally less than 2 pu. The calculation error of this method is close to that of the compensated neutron porosity measurement method. In addition, the applicability of the new method is analyzed without density data, and the results indicate that the calculation results are basically consistent with the results of calculation with density data. The new method has great potential for extensive applications in cased holes or open holes as an alternative for the compensated neutron porosity logging measurement method.
Difference in Immunogenic Responses to COVID-19 Vaccines in Patients With Cancer Receiving Chemotherapy Versus Nonchemotherapy Treatment
Authors: Tantiyavarong Walaipan , Sungkasubun Prakongboon , Chaiwiriyawong Worawit , Supavavej Archara , Limpawittayakul Piyarat , Weerasubpong Bowon , Siripaibun Jomtana , Phanthunane Chumut , Lamlertthon Wisut , Ungtrakul Teerapat , Tawinprai Kriangkrai , Tantiyavarong Pichaya , Samdaengpan Chayanee 
Published: March 2023

PURPOSE The COVID-19 pandemic has affected public health worldwide. The efficacy and safety of COVID-19 vaccines have been evaluated in the general population; however, data on patients with malignancies are limited. METHODS This prospective longitudinal observational cohort study was conducted between June and July 2021. Enrolled adult patients with cancer were divided into chemotherapy and nonchemotherapy groups. All participants were immunized with two doses of the ChAdOx1 nCoV-19 or CoronaVac COVID-19 vaccines. The primary outcome was a comparison of the immunogenicity (as assessed by spike protein [anti-S] immunoglobulin G [IgG] antibody titers) of two doses of COVID-19 vaccine in the chemotherapy and nonchemotherapy groups. The secondary outcomes included the anti-S IgG seroconversion rate and vaccine safety in both groups. RESULTS Among the 173 enrolled patients with solid cancer, after COVID-19 vaccination, the chemotherapy group had a significantly lower median anti-S IgG titer than the nonchemotherapy group (26 v 237 U/mL, P < .001). A statistically significant difference in anti-S IgG titer was found between groups vaccinated with CoronaVac (7 v 90 U/mL, P < .001), but no difference was found in those vaccinated with ChAdOx1 nCoV-19 (818 v 1061 U/mL, P = .075). The anti-S IgG seroconversion rate was significantly lower in the chemotherapy group than that in the nonchemotherapy group (78.9% v 96.5%, P = .001). No new or serious vaccine-related adverse events were reported. CONCLUSION Patients with solid cancer receiving a COVID-19 vaccine while undergoing chemotherapy had lower immunogenicity responses to vaccination than those who were vaccinated while undergoing nonchemotherapy treatment. No statistically significant difference was observed in the COVID-19 vaccine safety profiles between groups.
Comparing quantumness criteria
Authors: Martin Jérôme , Micheli Amaury , Vennin Vincent 
Published: March 2023

Abstract
Measuring the quantumness of a system can be done with a variety of methods. In this article we compare different criteria, namely quantum discord, Bell inequality violation and non-separability, for systems placed in a Gaussian state. When the state is pure, these criteria are equivalent, while we find that they do not necessarily coincide when decoherence takes place. Finally, we prove that these criteria are essentially controlled by the semi-minor axis of the ellipse representing the state's Wigner function in phase space.
Spinal Venous Vascular Ectasia With Unusual presentation of Abdominal Pain: Case Report
Authors: Ramon Juan Fernando , Rairan Luis García , Usuga Valentina , Mejia Juan Andrés 
Published: March 2023

BACKGROUND AND IMPORTANCE:
Spinal venous vascular ectasia associated with a low-flow fistula of paravertebral location is a very low-frequency entity. It usually manifests with myelopathy; however, in the present case, the symptomatology corresponded to thoracic radiculopathy, which can be difficult to diagnose and may be the cause of chronic pain refractory to analgesic management.

CLINICAL PRESENTATION:
An adult patient who consulted about a 1 year and a half of flank pain refractory to analgesic management and hypoesthesia on palpation in the left T8 dermatome, therefore, pain of radicular origin was suspected. MRI of the thoracic spine was requested, showing an image suggestive of vascular malformation at the level of T8. After identification of the lesion, the patient was taken to spinal angiography to delimit the vascular malformation, finding an image suggestive of spinal venous vascular ectasia associated with a low-flow fistula of paravertebral location at T8. Subsequently, the case was discussed by a multidisciplinary team that established endovascular embolization as the best option for treatment. Thus, achieving complete occlusion of the lesion without complications and a slow improvement of the symptoms.

CONCLUSION:
Spinal venous vascular ectasia associated with a low-flow fistula of paravertebral location is a very low-frequency entity that despite manifesting with myelopathy in some cases may generate radicular irritative symptoms and is differentiated from other lesions by its unusual location in spinal angiography.
Fibroblast-derived EGF ligand neuregulin 1 induces fetal-like reprogramming of the intestinal epithelium without supporting tumorigenic growth
Authors: Lemmetyinen Toni T. , Viitala Emma W. , Wartiovaara Linnea , Kaprio Tuomas , Hagström Jaana , Haglund Caj , Katajisto Pekka , Wang Timothy C. , Domènech-Moreno Eva , Ollila Saara 
Published: March 2023

ABSTRACT
Growth factors secreted by stromal fibroblasts regulate the intestinal epithelium. Stroma-derived epidermal growth factor (EGF) family ligands are implicated in epithelial regeneration and tumorigenesis, but their specific contributions and associated mechanisms remain unclear. Here, we use primary intestinal organoids modeling homeostatic, injured and tumorigenic epithelia to assess how the fibroblast-derived EGF family ligands neuregulin 1 (NRG1) and epiregulin (EREG) regulate the intestinal epithelium. NRG1 was expressed exclusively in the stroma, robustly increased crypt budding and protected intestinal epithelial organoids from radiation-induced damage. NRG1 also induced regenerative features in the epithelium, including a fetal-like transcriptome, suppression of the Lgr5+ stem cell pool and remodeling of the epithelial actin cytoskeleton. Intriguingly, unlike EGF and EREG, NRG1 failed to support the growth of pre-tumorigenic intestinal organoids lacking the tumor suppressor Apc, commonly mutated in human colorectal cancer (CRC). Interestingly, high expression of stromal NRG1 was associated with improved survival in CRC cohorts, suggesting a tumor-suppressive function. Our results highlight the power of stromal NRG1 in transcriptional reprogramming and protection of the intestinal epithelium from radiation injury without promoting tumorigenesis.
HuR modulation counteracts lipopolysaccharide response in murine macrophages
Authors: Bonomo Isabelle , Assoni Giulia , La Pietra Valeria , Canarutto Giulia , Facen Elisa , Donati Greta , Zucal Chiara , Genovese Silvia , Micaelli Mariachiara , Pérez-Ràfols Anna , Robbiati Sergio , Kontoyannis Dimitris L. , De Matteo Marilenia , Fragai Marco , Seneci Pierfausto , Marinelli Luciana , Arosio Daniela , Piazza Silvano , Provenzani Alessandro 
Published: March 2023

ABSTRACT
Lipopolysaccharide (LPS) exposure to macrophages induces an inflammatory response, which is regulated at the transcriptional and post-transcriptional levels. HuR (ELAVL1) is an RNA-binding protein that regulates cytokines and chemokines transcripts containing AU/U-rich elements (AREs) and mediates the LPS-induced response. Here, we show that small-molecule tanshinone mimics (TMs) inhibiting HuR–RNA interaction counteract LPS stimulus in macrophages. TMs exist in solution in keto-enolic tautomerism, and molecular dynamic calculations showed the ortho-quinone form inhibiting binding of HuR to mRNA targets. TM activity was lost in vitro by blocking the diphenolic reduced form as a diacetate, but resulted in prodrug-like activity in vivo. RNA and ribonucleoprotein immunoprecipitation sequencing revealed that LPS induces a strong coupling between differentially expressed genes and HuR-bound genes, and TMs reduced such interactions. TMs decreased the association of HuR with genes involved in chemotaxis and immune response, including Cxcl10, Il1b and Cd40, reducing their expression and protein secretion in primary murine bone marrow-derived macrophages and in an LPS-induced peritonitis model. Overall, TMs show anti-inflammatory properties in vivo and suggest HuR as a potential therapeutic target for inflammation-related diseases.
Aberrantly activated TAK1 links neuroinflammation and neuronal loss in Alzheimer's disease mouse models
Authors: Sai Kazuhito , Nakanishi Aoi , Scofield Kimberly M. , Tokarz Debra A. , Linder Keith E. , Cohen Todd J. , Ninomiya-Tsuji Jun 
Published: March 2023

ABSTRACT
Neuroinflammation is causally associated with Alzheimer's disease (AD) pathology. Reactive glia cells secrete various neurotoxic factors that impair neuronal homeostasis eventually leading to neuronal loss. Although the glial activation mechanism in AD has been relatively well studied, how it perturbs intraneuronal signaling, which ultimately leads to neuronal cell death, remains poorly understood. Here, we report that compound stimulation with the neurotoxic factors TNF and glutamate aberrantly activates neuronal TAK1 (also known as MAP3K7), which promotes the pathogenesis of AD in mouse models. Glutamate-induced Ca2+ influx shifts TNF signaling to hyper-activate TAK1 enzymatic activity through Ca2+/calmodulin-dependent protein kinase II, which leads to necroptotic cellular damage. Genetic ablation and pharmacological inhibition of TAK1 ameliorated AD-associated neuronal loss and cognitive impairment in the AD model mice. Our findings provide a molecular mechanism linking cytokines, Ca2+ signaling and neuronal necroptosis in AD.
Case Report: Competitive causes of death: a case report of non-mutilated but fatal traumatic railway injury
Authors: Purnamaningsih Sari Nur Indahty , Perwira Satria , Ramadhani Prasillia , Yudianto Ahmad 
Published: March 2023

Background: Railway-related accidents can cause severe injuries, and, most of the time, death. In a country with frequent railway-related accidents, a complete autopsy is vital to determine the cause and mechanism of death, reconstruct the events before death, and identify the victim. It is also essential to determine whether the deceased died by suicide or homicide. This article reports an autopsy of a non-identified victim from a train crash with two fatal injuries. In addition, we reported the challenges in establishing the cause and manner of death. Case presentation: A man was hit by a Pertamina train on Tuesday, 19 July 2022, at 00:24 West Indonesian Time (UTC+07:00), and this was reported to the police for investigation. The body was then examined at Dr. Soetomo General Academic Hospital by a forensic expert. The external examination suggested the presence of abrasions on the face, waist, and all four limbs, lacerations on the face and right earlobe, and open head fractures. In an internal examination, skull-base fractures, fourth and sixth right rib fractures, bleeding in the chest cavity, shrinking lungs, lacerations to the liver and lower right and left lungs, and blood infiltration in the chest cavity wall muscles and scalp muscles were found. The pneumothorax test was positive on the left chest but negative for heart air embolism. Investigation of the base of the skull revealed the presence of fractures. Conclusions: Determining the cause of death in a patient with multiple injuries was challenging and required a thorough investigation. Pneumothorax and air embolism could be the primary cause of death and their presence had to be investigated. Fractures of the base of the skull were established as the cause of death. According to the investigations at the crime scene and the injury profile, suicide was concluded as the manner of death.
Data presentation of results from randomized cancer clinical trials. The case for trials in advanced cervical cancer. A critical appraisal.
Authors: Duenas Gonzalez Alfonso , Coronel Jaime , Cabrera-Galeana Paula , Candelaria Myrna , Cano-Blanco Claudia 
Published: March 2023

In the last four decades, median survival has increased in advanced cervical cancer from 7.1 with single-agent cisplatin to 24 months with doublet chemotherapy plus bevacizumab plus pembrolizumab. Coinciding with the irruption of targeted therapy, we observe higher pricing of novel cancer drugs and results presentation aimed to positively impact the audience. The first could result in poor drug affordability and financial toxicity, while the second can give patients a magnified sense of progress. In this review, we briefly comment on study designs that may favor obtaining positive results but, most notably, how results are presented pertaining the latest randomized clinical trials in advanced cervical cancer. We found that survival results are expressed in Hazard Risk (HR) reductions but communicated as a Relative Risk (RR) reduction for death. The HR of the control to the experimental regimen is given by exp[β]. An HR of 0.7 means an HR reduction of 30%. Risk reduction derived from HR may lead to a belief that the intervention can eliminate the chance of the event occurring, but decreased HR means a reduction in the speed of the event to happen, not the chances to occur. On the contrary, the "risk reduction" based on RR means that patients have less chance of having the event because RR is a binary measure (alive or dead). Further, Absolute Risks and Number-To-Treat (NNT), in addition to Relative Risk, are omitted. The issue of how the results of cancer clinical trials are presented deserves open discussion. After all, it is the patient's right to make an informed decision for embarking on any cancer treatment.
Features and directions of development for control quality and acceptance of material resources for objects of the oil and gas companies
Authors: Siutin Denis , Kutsenko Svetlana 
Published: March 2023

IProject management and sustainable development are ones of the most important concepts that have gained great popularity in the scientific community in recent years. The need to integrate sustainability into project management is increasing every year changing the requirements for project managers` competencies.
Despite of the growing scientific interest in this topic, there is a small number of research papers that consider the impact of the concept of sustainability on the competences of a project manager. Thus, the purpose of this study is to identify the most important knowledge, skills and abilities and personal qualities needed by project managers for successful sustainable project management. The research is based on the analysis of the sources of scientific literature, international, and national standards in the field of project management.
The results showed that over the past 5 years the project manager profession has undergone significant changes, and in order to achieve sustainability project managers need to develop new professional competencies based on knowledge, skills and abilities, and personal qualities.