bluuebunny/crossref_metadata_2025_split huggingface dataset:
ДІНАМИКА НАГЛЯДУ(КОНТРОЛЮ) РЕГУЛЮВАННЯ ГОСПОДАРСЬКОЇ ДІЯЛЬНОСТІ З БОКУ ДЕРЖАВНИХ ОРГАНІВ
Authors: Гриценко Г.М. , Солодченко С.В. 
Published: July 2023

У статті досліджено аналіз діючого законодавства відносно здійснення нагляду (контролю) з бо-ку державних органів та органів місцевого самоврядування за господарською діяльністю. Проаналізова-на динаміка внесення змін з законодавство про здійснення нагляду (контролю) з боку органів державної влади в період воєнного стану в державі, враховуючи законодавство ЄС з даної тематики. Зазначені проблеми пов’язані із практичною реалізацією нагляду (контролю) органів державної влади і місцевого самоврядування за господарською діяльністю. Визначено що, необхідною умовою для сталого розвитку економіки держави потрібен нагляд (контроль) при регулюванні господарської діяльності (незалежно від обставин при яких проводиться господарська діяльність). Доведена необхідність функціонування інтегрованої автоматизованої системи державного нагляду (контролю)за господарською діяльністю, як елемент захисту порушених прав та інтересів суб’єктів господарювання від діяльності контролюю-чих органів.
Ключові слова: державний нагляд (контроль), господарська діяльність, державна регуляторна служба, інтегрованої автоматизованої системи , суб’єкти господарювання.
Pelatihan Webinar Publikasi Sekolah dan Teknologi Informasi bagi Mahasiswa Prodi MPI Angkatan 2020 STAIN Mandailing Natal
Authors: Defi Wahyufitrina 
Published: July 2023

Perubahan yang bergerak cepat pada era 5.0 tidak mungkin lagi ditolak bagi dunia pendidikan khususnya kalangan mahasiswa. Menerima perubahan itu adalah hal yang mutlak dan harus dijawab setuju oleh mahasiswa karena kalau tidak, justru ini menjadi bahaya bagi mereka karena semua hal sudah mulai berdampingan dengan digitalisasi. Mahasiswa prodi Manajemen Pendidikan Islam (MPI) STAIN Mandailing Natal angkatan 2020 pada mata kuliah Humas memiliki proyek tugas akhir dengan mengadakan webinar sesuai dengan tema perkuliahan. Hal ini adalah sesuatu yang baru bagi mahasiswa karena webinar yang diselenggarakan biasanya sifatnya masih luas dan belum mengerucut pada topik yang spesifik. Ditambah lagi dengan adanya kurikulum merdeka yang secara prinsip bahwa belajar itu tidak selalu membahas teori-teori tertentu tapi diharapkan secara khusus berorientasi pada project based learning strategy. Tujuan penulisan artikel pengabdian ini adalah melatih mahasiswa mampu mengadakan webinar secara mandiri dan mengupgrade pemahaman mahasiswa terkait mata kuliah Humas baik secara teori maupun praktik. Metode yang digunakan berlandaskan pada perencanaan, pengorganisasian, pelaksanaan, dan pengevaluasian. Hasil pengabdian ini berdampak pada pemahaman mahasiswa dalam melaksanakan webinar secara mandiri dengan persentase 75% dan pemahaman terhadap teori atau praktik humas sebanyak 90%.
Pengaruh Penamaan Merek Berbahasa Asing Terhadap Citra Merek Number Sixtyone Kota Bekasi Dengan Kognitif Konsumen Sebagai Variabel Intervening
Authors: Febrian Vira , Imaddudin Imaddudin , Athalarik Fadli Muhammad 
Published: July 2023

Industri fashion telah menjadi gaya hidup dan kepribadian masyarakat dengan persaingan yang sangat ketat, menarik konsumen melalui penggunaan bahasa asing sebagai identitas baru yang dikenal oleh konsumen. Penelitian kuantitatif ini bertujuan untuk mengetahui seberapa besar pengaruh nama merek berbahasa asing terhadap brand image Number Sixty One di Kota Bekasi dengan kognitif konsumen sebagai variabel intervening. Penelitian ini menggunakan metode survei dan pengumpulan data dilakukan dengan menggunakan kuesioner. Populasi dalam penelitian ini adalah 22.320 pengunjung toko Number Sixty One. Sampel penelitian dipilih berdasarkan teknik accidental sampling dengan jumlah 100 responden dan menggunakan SPSS Versi 25. Berdasarkan hasil penelitian dengan taraf signifikansi 5%, disimpulkan: (1) terdapat hubungan positif dan signifikan pengaruh antara variabel nama merek berbahasa asing dan nomor citra merek; (2) terdapat pengaruh positif dan signifikan antara variabel penamaan merek berbahasa asing dan kognitif konsumen number sixty one; (3) terdapat pengaruh positif dan signifikan antara variabel kognitif konsumen dan brand image number sixty one; (4) terdapat pengaruh positif dan signifikan antara variabel penamaan merek berbahasa asing terhadap citra merek dan kognitif konsumen sebagai variabel intervening.Kata kunci: Penamaan Merek Bahasa Asing, Citra Merek, Kognitif Konsumen
Associations between cord blood metabolic factors and early-childhood growth and overweight and obesity
Authors: Jin Wen-Yuan , Chen Xiao-Yang , Han Ting , Jin Yan , Chen Ting-Ting , Wang Zi-Han , Zhao Zheng-Yan , Zhu Zhi-Wei 
Published: July 2023

ObjectiveThis prospective cohort study was aimed at investigating the associations between cord blood metabolic factors and early-childhood growth, further elucidating the relationships between cord blood metabolites and overweight and obesity in early life.MethodsA total of 2,267 pairs of mothers and offspring were recruited in our study. Cord blood plasma was assayed for triglycerides (TGs), total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-C), high-density lipoprotein-cholesterol (HDL-C), C-peptide, insulin, and glycosylated hemoglobin type A1C (HbA1c) levels. Data of anthropometric measurements were collected from offspring at birth, 6 months, 12 months, and 18 months. Multiple linear regression models were used to evaluate the correlations between cord blood metabolic factors and weight Z-scores, body mass index (BMI) Z-scores, and weight gains at the early stage of life. Forward stepwise logistic regression analyses were applied to explore the associations between cord blood metabolic factors and early-childhood overweight and obesity. Receiver operating characteristic (ROC) curve analyses were applied to determine the optimal cutoff points for cord blood metabolic factors in predicting early-childhood overweight and obesity.ResultsAfter adjustments for covariates, cord blood TG concentrations and TG/TC ratios were negatively associated with weight Z-scores from birth to 18 months. Cord blood C-peptide and HbA1c levels were inversely associated with weight Z-scores at 6 months and 18 months. Cord blood TG concentrations and TG/TC ratios were negatively correlated with BMI Z-scores up to 18 months. Cord blood C-peptide levels and HbA1c levels were inversely correlated with BMI Z-scores at 18 months. Cord blood TG, TG/TC ratios, C-peptide, and HbA1c had negative correlations with weight gains from birth to 6 months, but the correlations attenuated as time went on. Increase in cord blood TG and HbA1c levels and TG/TC ratios were significantly associated with decreased risks of overweight and obesity at 6 months, 12 months, and 18 months.ConclusionsCord blood metabolic factors were significantly associated with early-childhood growth patterns.
Components of the metabolic syndrome in girls with Turner syndrome treated with growth hormone in a long term prospective study
Authors: Błaszczyk Ewa , Shulhai Anna-Mariia , Gieburowska Joanna , Barański Kamil , Gawlik Aneta Monika 
Published: July 2023

BackgroundComponents of the metabolic syndrome are more common in patients with Turner syndrome (TS) than in the general population. Long-term growth hormone (GH) treatment also affects the parameters of carbohydrate metabolism. Therefore, all these factors should be monitored in girls with TS.ObjectiveTo assess the occurrence of metabolic syndrome components in TS girls before GH treatment and to monitor changes in metabolic parameters throughout GH therapy.Patients and method89 TS patients were enrolled in the study. Clinical and laboratory data after the 1st (V1), 3rd (V3), 5th (V5) and 10th (V10) year of GH therapy was available respectively in 60, 76, 50 and 22 patients. The patients’ biochemical phenotypes were determined by glucose 0’, 120’, insulin 0’, 120’, HOMA-IR, Ins/Glu ratio, HDL-cholesterol and triglycerides (TG) concentration.ResultsObesity was found during V0 in 7.9% of patients,V1 - 5%, V3 - 3.9%, V5 - 2%, V10 – 0%. No patient met diagnostic criteria for diabetes. A significant increase in the basal plasma glucose 0’ was found in the first five years of therapy (pV0-V1 &lt; 0.001; pV0-V3 = 0.006; pV0-V5 &lt; 0.001). V10 glucose 120’ values were significantly lower than at the onset of GH treatment (pV0-V10 = 0.046). The serum insulin 0’ and 120’ concentrations as well as insulin resistance increased during treatment. No statistically significant differences in serum TG and HDL-cholesterol levels during GH therapy were found.ConclusionThe development of insulin resistance and carbohydrate metabolism impairment have the greatest manifestations during GH therapy in girls with TS. Monitoring the basic parameters of carbohydrate-lipid metabolism in girls with TS seems particularly important.
PheSom: a term frequency-based method for measuring human phenotype similarity on the basis of MeSH vocabulary
Authors: Liu Xinhua , Gao Ling , Peng Yonglin , Fang Zhonghai , Wang Ju 
Published: July 2023

Background: Phenotype similarity calculation should be used to help improve drug repurposing. In this study, based on the MeSH terms describing the phenotypes deposited in OMIM, we proposed a method, namely, PheSom (Phenotype Similarity On MeSH), to measure the similarity between phenotypes. PheSom counted the number of overlapping MeSH terms between two phenotypes and then took the weight of every MeSH term within each phenotype into account according to the term frequency-inverse document frequency (FIDC). Phenotype-related genes were used for the evaluation of our method.Results: A 7,739 × 7,739 similarity score matrix was finally obtained and the number of phenotype pairs was dramatically decreased with the increase of similarity score. Besides, the overlapping rates of phenotype-related genes were remarkably increased with the increase of similarity score between phenotypes, which supports the reliability of our method.Conclusion: We anticipate our method can be applied to identifying novel therapeutic methods for complex diseases.
Identification of S100A8 as a common diagnostic biomarkers and exploring potential pathogenesis for osteoarthritis and metabolic syndrome
Authors: Huang Xu , Liu Jiacheng , Huang Wei 
Published: July 2023

BackgroundOsteoarthritis (OA) is the most frequent musculoskeletal disease and the major contributor to disability worldwide. Metabolic syndrome (MetS) has been recognized as being associated with the pathogenesis of osteoarthritis. However, the exact mechanisms and links between the two are not clear.MethodsWe downloaded clinical information data and gene expression profiles for OA and MetS from the database of Gene Expression Omnibus (GEO), and immune related gene (IRG) from the database of Immunology Database and Analysis Portal (IMMPORT). After screening OA-DEG and MetS-DEG, we identified the common immune hub gene by screening the overlapping genes between OA-DEG, MetS-DEG and IRG. Then we conducted single-gene analysis of S100A8, assessed the correlation of S100A8 with immune cell infiltration, and verified the diagnostic value of S100A8 in OA and MetS database respectively.Results323 OA-DEGs,101 MetS-DEGs and an immune-related hub gene, S100A8, were identified. In single gene analysis of S100A8 in OA samples, GSEA suggested that immune-related biological processes were more significantly enriched. The results of immune cell infiltration analysis showed that the enrichment fraction of M2 macrophages was significantly higher in the high S100A8-expressing group, and the level of S100A8 expression was positively correlated with M2 macrophage infiltration. The results of the dataset validation showed that S100A8 expression levels were significantly upregulated in the OA group and performed well in the diagnosis of OA. In single gene analysis of S100A8 in MetS samples, immune cell infiltration analysis showed that monocyte infiltration was higher in the S100A8 high expression samples and that there was a positive correlation between the two. Dataset validation showed that S100A8 is of high value for the diagnosis of MetS. In the validation of the dataset for the four metabolism-related diseases (obesity, diabetes, hypertension and hyperlipidaemia), S100A8 was expressed at higher levels in the disease group and also had a higher diagnostic value for the four metabolism-related diseases.ConclusionS100A8 is a common hub gene and diagnostic biomarker for OA and MetS, and the immune regulation involved in S100A8 may play a central role in the pathogenesis of OA and MetS.
Suppression of microglial Ccl2 reduces neuropathic pain associated with chronic spinal compression
Authors: Li Quan , Yang Zongde , Wang Kun , Chen Zhi , Shen Hongxing 
Published: July 2023

IntroductionChronic spinal compression is a common complication of spinal cord injury (SCI), which can lead to spinal stenosis or herniated discs. The ensuing neuropathic pain is often associated with the activation of microglia. In this investigation, our objective was to explore whether modifying the levels of chemokine (C-C motif) ligand 2 (Ccl2) in microglia could alleviate neuropathic pain resulting from chronic spinal compression.MethodsWe used a public database to look for major altered gene associated in a SCI model established in rats. We then employed adeno-associated virus (AAV) vectors, expressing siRNA for the identified significantly altered gene under a microglia-specific TMEM119 promoter. We also tested the impact of this treatment in microglia in vivo on the severity of chronic spinal compression and associated pain using a ttw mouse model for progressive spinal compression.ResultsWe identified chemokine (C-C motif) ligand 2 (Ccl2) as the primary gene altered in microglia within a rat SCI model, utilizing a public database. Microglial Ccl2 levels were then found to be significantly elevated in disc specimens from SCI patients diagnosed with chronic spinal compression and strongly correlated with the Thompson classification of the degeneration level and pain score. Depletion of Ccl2 in microglia-specific TMEM119 promoter were developed to transfect mouse microglia in vitro, resulting in a proinflammatory to anti-inflammatory phenotypic adaption. In vivo depletion of Ccl2 in microglia mitigated the severity of chronic spinal compression and related pain in ttw mice, likely due to significant changes in pain-associated cytokines and factors.ConclusionDisc microglia expressing high levels of Ccl2 may contribute to chronic spinal compression and SCI-associated pain. Therapeutically targeting Ccl2 in microglia could offer a potential avenue for treating chronic spinal compression and SCI-associated pain.
Whole-body bioluminescence imaging of T-cell response in PDAC models
Authors: McMorrow Roisin , Zambito Giorgia , Nigg Alex , Lila Karishma , van den Bosch Thierry P. P. , Lowik Clemens W. G. M. , Mezzanotte Laura 
Published: July 2023

IntroductionThe location of T-cells during tumor progression and treatment provides crucial information in predicting the response in vivo.MethodsHere, we investigated, using our bioluminescent, dual color, T-cell reporter mouse, termed TbiLuc, T-cell location and function during murine PDAC tumor growth and checkpoint blockade treatment with anti-PD-1 and anti-CTLA-4. Using this model, we could visualize T-cell location and function in the tumor and the surrounding tumor microenvironment longitudinally. We used murine PDAC clones that formed in vivo tumors with either high T-cell infiltration (immunologically ‘hot’) or low T-cell infiltration (immunologically ‘cold’).ResultsDifferences in total T-cell bioluminescence could be seen between the ‘hot’ and ‘cold’ tumors in the TbiLuc mice. During checkpoint blockade treatment we could see in the tumor-draining lymph nodes an increase in bioluminescence on day 7 after treatment.ConclusionsIn the current work, we showed that the TbiLuc mice can be used to monitor T-cell location and function during tumor growth and treatment.
Short-term outcomes of robot-assisted versus video-assisted thoracoscopic surgery for non-small cell lung cancer patients with neoadjuvant immunochemotherapy: a single-center retrospective study
Authors: Pan Hanbo , Zou Ningyuan , Tian Yu , Zhu Hongda , Zhang Jiaqi , Jin Weiqiu , Gu Zenan , Ning Junwei , Li Ziming , Kong Weicheng , Jiang Long , Huang Jia , Luo Qingquan 
Published: July 2023

BackgroundNeoadjuvant immunochemotherapy has been increasingly applied to treat non-small cell lung cancer (NSCLC). However, the comparison between robotic-assisted thoracoscopic surgery (RATS) and video-assisted thoracoscopic surgery (VATS) in the feasibility and oncological efficacy following neoadjuvant immunochemotherapy is scarce. This study aims to assess the superiorities of RATS over (VATS) concerning short-term outcomes in treating NSCLC patients with neoadjuvant immunochemotherapy.MethodsNSCLC patients receiving RATS or VATS lobectomy following neoadjuvant immunochemotherapy at Shanghai Chest Hospital from 2019 to 2022 were retrospectively identified. Baseline clinical characteristics, perioperative outcomes, and survival profiles were analyzed.ResultsForty-six NSCLC patients with neoadjuvant immunochemotherapy were included and divided into the RATS (n=15) and VATS (n=31) groups. The baseline clinical characteristics and induction-related adverse events were comparable between the two groups (all p&gt;0.050). The 30-day mortality in the RATS and VATS groups were 0% and 3.23%, respectively (p=1.000). Patients undergoing RATS were associated with reduced surgical-related intensive unit care (ICU) stay than those receiving VATS (0.0 [0.0-0.0] vs. 0.0 [0.0-1.0] days, p=0.026). Moreover, RATS assessed more N1 LNs (6.27 ± 1.94 vs 4.90 ± 1.92, p=0.042) and LN stations (3.07 ± 1.03 vs 2.52 ± 0.57, p=0.038) compared with VATS. By comparison, no difference was found in surgical outcomes, pathological results, and postoperative complications between the RATS and VATS groups (all p&gt;0.050). Finally, RATS and VATS achieved comparable one-year recurrence-free survival (82.96% vs. 85.23%, p=0.821) and the timing of central nervous system, LN, and bone recurrences (all p&gt;0.050).ConclusionRATS is safe and feasible for NSCLC patients with neoadjuvant immunochemotherapy, reducing surgical-related ICU stay, assessing increased N1 LNs and stations, and achieving similar survival profiles to VATS.
Legal medicine aspects of female sterilization: our experience
Authors: Fedeli Piergiorgio , Cecchi Stefano , Scendoni Roberto , Cannovo Nunzia 
Published: July 2023

IntroductionThe most frequent sterilization procedures include postpartum tubal ligation, laparoscopic tubal disruption or salpingectomy, and hysteroscopic tubal occlusion. It may be performed via laparoscopy, mini-laparotomy, or hysteroscopy. Safety, efficacy, short-term complications, long-term complications, and non-contraceptive benefits of sterilization are different for each procedure. Female sterilization has become an important professional liability problem in obstetrics and gynecology.Materials and methodsWe analyzed 6 cases of surgical sterilization that have been the subject of civil proceedings. We review indications, contraindications, and complications associated with each sterilization procedure.ResultsIn our small number of cases, women who have undergone sterilization performed negligently are entitled to recover damages for wrongful conception, negligence, and wrongful birth. We also consider the issue of female sterilization of minors.DiscussionTubal sterilization can be performed with different techniques, chosen in light of the various situations involved, with the goal of reducing as many as possible any failures. Thorough and complete communication of information is of primary importance.ConclusionSterilization is the most widely used birth control method around the world. The procedure is generally safe and highly effective. As reported in the literature, the decision concerning method depends on the setting, the surgeon’s experience, the country’s economic development, and the woman’s preference, but we think that some techniques present a greater risk of failure and expose the surgeon to malpractice litigation.
Development and validation of a deep-broad ensemble model for early detection of Alzheimer's disease
Authors: Ma Peixian , Wang Jing , Zhou Zhiguo , Chen C. L. Philip ,   The Alzheimer's Disease Neuroimaging Initiative, Duan Junwei 
Published: July 2023

IntroductionAlzheimer's disease (AD) is a chronic neurodegenerative disease of the brain that has attracted wide attention in the world. The diagnosis of Alzheimer's disease is faced with the difficulties of insufficient manpower and great difficulty. With the intervention of artificial intelligence, deep learning methods are widely used to assist clinicians in the early recognition of Alzheimer's disease. And a series of methods based on data input with different dimensions have been proposed. However, traditional deep learning models rely on expensive hardware resources and consume a lot of training time, and may fall into the dilemma of local optima.MethodsIn recent years, broad learning system (BLS) has provided researchers with new research ideas. Based on the three-dimensional residual convolution module and BLS, a novel broad-deep ensemble model based on BLS is proposed for the early detection of Alzheimer's disease. The Alzheimer's Disease Neuroimaging Initiative (ADNI) MRI image dataset is used to train the model and then we compare the performance of proposed model with previous work and clinicians' diagnosis.ResultsThe result of experiments demonstrate that the broad-deep ensemble model is superior to previously proposed related works, including 3D-ResNet and VoxCNN, in accuracy, sensitivity, specificity and F1.DiscussionThe proposed broad-deep ensemble model is effective for early detection of Alzheimer's disease. In addition, the proposed model does not need the pre-training process of its depth module, which greatly reduces the training time and hardware dependence.