bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rapid, Activity-Dependent Intrinsic Plasticity in the Developing Zebra Finch Auditory Cortex
Authors: Lu Yao , Sciaccotta Francesca , Kiely Leah , Bellanger Benjamin , Erisir Alev , Meliza C. Daniel 
Published: August 2023

The acoustic environment an animal experiences early in life shapes the structure and function of its auditory system. This process of experience-dependent development is thought to be primarily orchestrated by potentiation and depression of synapses, but plasticity of intrinsic voltage dynamics may also contribute. Here, we show that in juvenile male and female zebra finches, neurons in a cortical-level auditory area, the caudal mesopallium (CM), can rapidly change their firing dynamics. This plasticity was only observed in birds that were reared in a complex acoustic and social environment, which also caused increased expression of the low-threshold potassium channel Kv1.1 in the plasma membrane and endoplasmic reticulum (ER). Intrinsic plasticity depended on activity, was reversed by blocking low-threshold potassium currents, and was prevented by blocking intracellular calcium signaling. Taken together, these results suggest that Kv1.1 is rapidly mobilized to the plasma membrane by activity-dependent elevation of intracellular calcium. This produces a shift in the excitability and temporal integration of CM neurons that may be permissive for auditory learning in complex acoustic environments during a crucial period for the development of vocal perception and production.SIGNIFICANCE STATEMENTNeurons can change not only the strength of their connections to other neurons, but also how they integrate synaptic currents to produce patterns of action potentials. In contrast to synaptic plasticity, the mechanisms and functional roles of intrinisic plasticity remain poorly understood. We found that neurons in the zebra finch auditory cortex can rapidly shift their spiking dynamics within a few minutes in response to intracellular stimulation. This plasticity involves increased conductance of a low-threshold potassium current associated with the Kv1.1 channel, but it only occurs in birds reared in a rich acoustic environment. Thus, auditory experience regulates a mechanism of neural plasticity that allows neurons to rapidly adapt their firing dynamics to stimulation.
Loss of BRD4 induces cell senescence in HSC/HPCs by deregulating histone H3 clipping
Authors: Yang Hui , Sui Pinpin , Guo Ying , Chen Shi , Maloof Marie E , Ge Guo , Nihozeko Francine , Delma Caroline R , Zhu Ganqian , Zhang Peng , Ye Zhenqing , Medina Edward A , Ayad Nagi G , Mesa Ruben , Nimer Stephen D , Chiang Cheng‐Ming , Xu Mingjiang , Chen Yidong , Yang Feng‐Chun 
Published: August 2023

AbstractBromodomain‐containing protein 4 (BRD4) is overexpressed and functionally implicated in various myeloid malignancies. However, the role of BRD4 in normal hematopoiesis remains largely unknown. Here, utilizing an inducible Brd4 knockout mouse model, we find that deletion of Brd4 (Brd4Δ/Δ) in the hematopoietic system impairs hematopoietic stem cell (HSC) self‐renewal and differentiation, which associates with cell cycle arrest and senescence. ATAC‐seq analysis shows increased chromatin accessibility in Brd4Δ/Δ hematopoietic stem/progenitor cells (HSC/HPCs). Genome‐wide mapping with cleavage under target and release using nuclease (CUT&RUN) assays demonstrate that increased global enrichment of H3K122ac and H3K4me3 in Brd4Δ/Δ HSC/HPCs is associated with the upregulation of senescence‐specific genes. Interestingly, Brd4 deletion increases clipped H3 (cH3) which correlates with the upregulation of senescence‐specific genes and results in a higher frequency of senescent HSC/HPCs. Re‐expression of BRD4 reduces cH3 levels and rescues the senescence rate in Brd4Δ/Δ HSC/HPCs. This study unveils an important role of BRD4 in HSC/HPC function by preventing H3 clipping and suppressing senescence gene expression.
ФОРМУВАННЯ ЕКОНОМІЧНОГО ПРОФІЛЮ СТРАТЕГІЧНО ВАЖЛИВИХ ВИДІВ ПРОМИСЛОВОЇ ДІЯЛЬНОСТІ В УКРАЇНІ (РЕТРОСПЕКТИВНИЙ ПОГЛЯД)
Authors: ГЕЄЦЬ Валерій 
Published: August 2023

Проаналізовано питання, пов’язані з переформатуванням економічного профілю стратегічно важливих видів промислової діяльності в Україні в довоєнний період, розкрито зміст змін, що відбулися в 1995–2021 рр., у порівнянні з відповідними змінами, які характерні для окремих країн ЄС, зокрема, Німеччини як одного з лідерів в економічному просторі ЄС, а також Польщі, Чехії, Словаччини і Естонії, які пройшли період трансформації економіки від домінуючої планово-розподільної системи до ринкової і, врешті-решт, досягли успіху, ставши членами Європейського Союзу.
Серед основних результатів аналізу структурних змін у економіці України і окремих країн ЄС однозначно простежується відсталість української економіки в частині скорочення тих видів промислової діяльності, які формують порівняно високу питому вагу доданої вартості, що зумовлює втрату конкурентних позицій на тлі розглядуваних країн. Відповідно має місце зумовлена домінуванням експорту продовольчих товарів і сировини для їх виробництва, а також промислової продукції, пов’язаної з видобутком мінерально-сировинних ресурсів та їх первинною переробкою, реструктуризація зовнішньої торгівлі України в напрямі примітивізації. Паралельно в імпорті зросла частка продукції виробничого призначення з більш високою питомою вагою доданої вартості, що призвело до формування технологічної залежності та загроз поглиблення подальшого переформатування промисловості в напрямі її периферизації.
На основі аналізу позитивних і негативних складових промислової політики повоєнного відновлення і розвитку економіки, що раніше застосовувалися в окремих країнах світу, а також з огляду на наявність в Україні частини промислових виробництв високотехнологічного характеру показано, як шляхом використання наявного історичного досвіду, в тому числі й вітчизняного, можна оминути існуючі загрози, виконуючи так звані "домашні завдання" для забезпечення стабільності розвитку держави.
Дана стаття є певним підсумком ретроспективного аналізу характеру розвитку стратегічно важливих видів промислової діяльності майже за останні 20 років. Погляд же на майбутнє буде визначено автором у наступній публікації, запланованій до кінця 2023 р.
AN ASSESSMENT OF THE SOFTWARE ENGINEERING CURRICULUM IN TURKISH UNIVERSITIES : IEEE/ACM GUIDELINES PERSPECTIVE
Authors: Mishra Alok , Yazici Ali 
Published: August 2023

Software engineering (SE) education has been emerging as an independent and mature discipline. Accordingly, various studies are being done to provide guidelines for SE education curriculum design. This paper presents software engineering education evolvement in Turkey, present SE education scenario in different universities along with the significance of software technology parks in relevance to software engineering education. The objective of this paper is to provide an assessment of SE curriculum in Turkish Universities with respect to IEEE/ACM guidelines given in SEEK (2004). This study will provide a guideline to universities conducting an SE programme at undergraduate level to align their course curriculum with IEEE/ACM guidelines (SEEK, 2004). Keywords: Curriculum, Software Engineering Education, Software Engineering, Software Industry, Turkey---------------------- Obrazovanje programskih inženjera (PI) razvija se kao samostalna i zrela znanstvena disciplina. Sukladno tome, provode se različita istraživanja u cilju određivanja smjernica za izradu nastavnih planova i programa za obrazovanje PI. Ovaj rad predstavlja razvoj obrazovanja programskih inženjera u Turskoj, trenutnu situaciju u obrazovanju PI na različitim sveučilištima, kao i značenje tehnoloških parkova za njihovo obrazovanje. Cilj ovoga rada je dati evaluaciju nastavnoga plana i programa za Programsko inženjerstvo na turskim sveučilištima s obzirom na IEEE/ACM smjernice navedene u dokumentu SEEK (2004). Ova će studija pružiti smjernice sveučilištima prilikom provođenja programa PI na dodiplomskoj razini kako bi se uskladio plan i program kolegija s IEEE/ACM smjernicama (SEEK, 2004). Ključne riječi: nastavni plan i program, obrazovanje programskih inženjera, programsko inženjerstvo, softverska industrija, Turska
Brain responses to positive and negative events in individuals with internet gaming disorder during real gaming
Authors: Zhang Zhengjie , Wang Shizhen , Du Xiaoxia , Qi Yanyan , Wang Lingxiao , Dong Guang-Heng 
Published: August 2023

AbstractObjectiveThis study sought to investigate brain responses to positive and negative events in individuals with internet gaming disorder (IGD) during real gaming as a direct assessment of the neural features of IGD. This investigation reflects the neural deficits in individuals with IGD while playing games, providing direct and effective targets for prevention and treatment of IGD.MethodsThirty subjects with IGD and fifty-two matched recreational game use (RGU) subjects were scanned while playing an online game. Abnormal brain activities during positive and negative events were detected using a general linear model. Functional connectivity (FC) and correlation analyses between neural features and addiction severity were conducted to provide additional support for the underlying neural features.ResultsCompared to the RGU subjects, the IGD subjects exhibited decreased activation in the dorsolateral prefrontal cortex (DLPFC) during positive events and decreased activation in the middle frontal gyrus (MFG), precentral gyrus and postcentral gyrus during negative events. Decreased FC between the DLPFC and putamen during positive events and between the MFG and amygdala during negative events were observed among the IGD subjects. Neural features and addiction severity were significantly correlated.ConclusionsIndividuals with IGD exhibited deficits in regulating game craving, maladaptive habitual gaming behaviors and negative emotions when experiencing positive and negative events during real game-playing compared to RGU gamers. These abnormalities in neural substrates during real gaming provide direct evidence for explaining why individuals with IGD uncontrollably and continuously engage in game playing, despite negative consequences.
Academic stress, hair and saliva cortisol, and their relationship with body mass index and fat percentage in first year medical students
Authors: Romero-Romero Emilio , De León Estela Guerreo , Morán-Pinzón Juan , Salado-Castillo Rigoberto , Castillo-Pimentel Armando 
Published: August 2023

AbstractIntroductionAlthough a large part of the population may be exposed to various pressures that can lead to mental or eating problems and increased perceived stress, the transition from adolescence to adulthood has been shown to be a crucial stage. Medical students are particularly vulnerable during the transition period as they must adapt to new circumstances, which may contribute to increased perceived stress. Cortisol plays an important role between stress, weight gain, and the development of obesity. We designed a study to investigate the association between stress, eating behaviour, cortisol, and body weight in a sample of first-year medical students.MethodsWe determined 75 first-year medical students' hair and salivary cortisol concentrations by ELISA and related it to self-reported stress, eating behaviour, and anthropometric measurements throughout the academic period. The prevalence of overweight and obesity in females was 25% and 10%, and in males was 35% and 6%, respectively. We report an increase in hair cortisol, higher self-reported stress scores, and BMI mainly in females. Finally, we found evidence of positive associations between hair cortisol and BMI in females (r = 0.348) and males (r = 0.423).ConclusionThere is a low association between short-term single-point cortisol measures and long-term cortisol, mainly in males. Hence, short-term cortisol reactivity is moderately associated with long-term cortisol reactivity when both are evaluated simultaneously. These results support the previous evidence of positive associations between cortisol with body fat percentage and BMI, and finally, that eating behaviours are modified by academic stress perception, mainly in females.
Fundamental Movement Skills in Children in Mentawai Islands: Indigenous Tribes in Indonesia
Authors: Komaini Anton , Kiram Yanuar , Gusril  , Mario Deby Tri , Handayani Sri Gusti , Erianjoni  
Published: August 2023

Background and purpose. Various studies have investigated Fundamental Movement Skills (FMS) in children and factors that might improve them. However, studies examining FMS in children of indigenous tribes remain limited. Thus, this research aims to identify and analyze the relationship between sociocultural life, parenting, and level of education among indigenous tribe children who live on Mentawai Island. The research is also keen on comparing FMS between genders.
Materials and methods. This research employed qualitative and quantitative methods. It was grounded by phenomenology and FMS tests. A total of 15 parents, 3 teachers, and 70 young children (aged 5-7 years) participated voluntarily. The children’s genders comprised boys (n=38) and girls (n=32). Data in this research were collected from observation, semi-structured interviews, and FMS tests (locomotor, non-locomotor and manipulative). Then, they were analyzed using a thematic method and t-test to compare the level of FMS among the children.
Results. Based on the analysis, parents stated they involved their children in socio-cultural life. Also, children were educated to live independently and given freedom to play. However, the study did not find any relationship between parent’s educational level and FMS. This was evidenced by statistical analysis, in which the mean score of FMS among early childhood in Mentawai Island was 35.46 (good). Following that, boys had better FMS than girls (P<0,05), with a mean score of 37.08>33.53.
Conclusions. Children need to be given the freedom to actively take part in physical activities in order to gain physical experiences and better FMS. This study recommends future research involving other factors and comparing FMS between children of indigenous tribes and those who live in urban areas.
Mechanically Coupled Areas on the Plate Interface in the Kanto Region, Central Japan, Generating Great Earthquakes and Slow-Slip Events
Authors: Saito Tatsuhiko , Noda Akemi 
Published: August 2023

ABSTRACT
We detected the mechanically coupled areas, or high stress rate patches, on the plate interface in the Kanto region, central Japan, by analyzing the Global Navigation Satellite Systems data. The estimated patches correspond well with the focal areas of past great earthquakes and slow-slip events (Mw∼6.5) occurring every ∼5 yr. Using one of the estimated patches, we created a model of a slow-slip event as a stress release with a recurrence interval of 5 yr. This synthetic can reproduce observed features of the slow-slip events such as the slip distribution and the magnitude. We use the strain-energy magnitude Mw0 defined by the minimum strain-energy release to quantify the magnitude. This is useful to compare slow-slip events with ordinary earthquakes in terms of the strain energy release, whereas the moment magnitude does not represent the difference of the energy release in this case. The strain-energy magnitude of the slow-slip event was Mw0 4.9, which was considerably smaller than the moment magnitude, because the smaller stress drop of the slow-slip event results in a smaller strain-energy release. Furthermore, by assuming that stress has accumulated at the other patches corresponding to the source region of past earthquakes since the occurrence of the last earthquakes, we obtain a model of the stress accumulation in 2023. We then create various rupture scenarios of great earthquakes as combinations of ruptures of the different patches. When two or three of the patches release the accumulated stress simultaneously, an interplate earthquake with Mw≥7.8 can occur in the Kanto region.
Identification of Repeating Earthquakes: Controversy and Rectification
Authors: Gao Dawei , Kao Honn , Liu Jianxin 
Published: August 2023

Abstract
Repeating earthquakes (repeaters) are events that recurrently rupture the same fault patch with nearly identical magnitudes. Although repeaters have been widely studied and utilized in many fields over the last four decades, there are no standard criteria for reliably identifying such events. The current criteria adopted in the geophysical research community are inconsistent and difficult to justify. Different criteria may inescapably incur inadequate hypotheses and lead to controversial interpretations, highlighting the urgent need for seeking a uniform approach to reliably identify repeaters. In this study, we address this long-standing issue by deriving the most logical criteria on the basis of theoretical calculation with simple yet reasonable assumptions. Quantitatively, we define a repeating pair if their interevent distance is ≤80% of the rupture area of the larger event and their magnitude difference is ≤0.3. We demonstrate the superiority of our proposed approach with challenging cases in California, and our results shed new insight into the hierarchical fault structures in the source areas. Although this study focuses on defining repeating earthquakes, the application to repeating seismic events in other planetary bodies such as moonquakes and marsquakes is straightforward, potentially help avoid misinterpretations of the physical processes in both Earth and planetary interiors.
Socio-economic determinants of environmental degradation: empirical evidence for the environmental Kuznets Curve
Authors: Gültekin Ömer Faruk , Sayar Ramazan , Ari Yılmaz Onur 
Published: August 2023

The aim of the paper is to examine socio-economic determinants of environmental degradation. The empirical study employs quantile regression which enables separate predictions for different levels of the dependent variable to be made. This study investigated 62 countries from low, middle and some high income countries for 1995-2019. The Environmental Kuznets Curve (EKC) is verified for the aforemented countries in analyzing the relationship between economic growth and carbon emissions using quantile regression. The study also revealed that the schooling rate has a pollution-increasing effect. In addition to the reducing effects of trade openness, democracy, and economic freedom variables on environmental degradation, the opposite effect of life expectancy at birth is observed, increasing environmental degradation. In this context, this paper concluded that the EKC hypothesis is not supported. The government should encourage pollution-reducing policies in low and middle income countries.
The Effect of Surgeon Volume on Revision for Periprosthetic Joint Infection
Authors: Vaotuua D. , O’Connor P. , Belford M. , Lewis P. , Hatton A. , Holder C. , McAuliffe M. 
Published: August 2023

Background:
Periprosthetic joint infection (PJI) is a devastating complication of total knee arthroplasty (TKA). An association between low surgeon volume and higher rates of infection following primary TKA has been suggested. The purpose of the present study was to determine if there was a relationship between surgeon volume and the rate of revision for infection after primary TKA.

Methods:
We searched the Australian Orthopaedic Association National Joint Replacement Registry (AOANJRR) to identify all primary TKA procedures that were performed for the treatment of osteoarthritis from September 1, 1999, to December 31, 2020, and were subsequently revised because of infection. Surgeon volume was defined as the annual volume of procedures performed by a surgeon during the same year in which the primary TKA (which was subsequently revised for infection) was performed. Surgeon volume was defined as <25, 25 to 49, 50 to 74, 75 to 99, or ≥100 primary TKA procedures/year. The cumulative percent revision (CPR) for infection was determined with use of Kaplan-Meier estimates. Cox proportional hazards methods were used to compare rates of revision for infection by surgeon volume, with subanalyses for patellar resurfacing and polyethylene use. Further analyses for patients <65 years of age and male patients were undertaken.

Results:
Overall, 602,919 primary TKA procedures were performed for the treatment of osteoarthritis, of which 5,295 were revised because of infection. High-volume surgeons (≥100 TKAs/year) had a significantly lower rate of revision for infection, with a CPR at 1 and 19 years of 0.4% (95% confidence interval [CI], 0.3 to 0.4) and 1.5% (95% CI, 1.2 to 2.0), respectively, compared with 0.6% (95% CI, 0.5 to 0.7) and 2.1% (95% CI, 1.8 to 2.3), respectively, for low-volume surgeons (<25 TKAs/year). Hazard ratios (HRs), adjusted for age and sex, comparing these 2 groups varied, depending on the time point, between 3.07 (95% CI, 2.02 to 4.68) and 1.44 (95% CI, 1.26 to 1.63) but remained significant (p < 0.001). When the analysis was adjusted for age, sex, American Society of Anesthesiologists (ASA) classification, and body mass index (BMI), there remained an increased risk of revision for PJI for all lower surgeon volume levels in comparison with the high- surgeon-volume group (≥100 TKAs/year). The results were similar when stratified by patellar resurfacing and cross-linked polyethylene (XLPE) and adjusted for age and sex.

Conclusions:
High-volume surgeons had lower rates of revision for infection. A better understanding of how surgical volume contributes to decreasing this complication is important and requires in-depth study.

Level of Evidence:
Prognostic Level III. See Instructions for Authors for a complete description of levels of evidence.
Failure Analysis and Countermeasures for Cement Sheath Interface Sealing Integrity in Shale Gas Wells
Authors: Li Jin , Liu Jian , Li Zaoyuan , Liu Yang , Yu Caijun , Song Weitao , Wu Xuning , Yang Fujie , Su Donghua 
Published: August 2023

Summary
Shale gas development usually uses large displacement horizontal well and staged fracturing technology to increase operation production. The complex environmental and construction conditions often lead to wellbore sealing integrity problems in the shale gas production process. This study shows a new method for evaluating the sealing integrity of shale gas cement sheath interfaces, which aims to understand the failure mechanism during shale gas production and to propose countermeasures that can effectively improve the sealing integrity of cement sheath interfaces in shale gas cementing. The study results showed that the oil contamination of cement sheath interface will greatly weaken its sealing performance. After repeated cyclic loading, the sealing performance of the conventional and expanded cement sheath assemblies is damaged, and a gas channel is formed, which is caused by the combination of microcracks and microgaps. Furthermore, oil contamination of the cement sheath interface will accelerate its sealing failure. The addition of an expansion agent is helpful to solve the problem of microgap destruction, and the fibers or whiskers can alleviate the problem of tensile cracking. The field application in the three wells proved that the toughened expanded cement slurry significantly improved the sealing integrity of the cement sheath interface in shale gas wells. The research results can evaluate and predict the sealing performance of the cement sheath interface in shale gas wells under the conditions of staged fracturing and have some directional significance for the cement slurry system optimization in the field.