bluuebunny/crossref_metadata_2025_split huggingface dataset:
‘Still not scraping the bottom of the barrel’: ‘Rich points’, feedback, disadvantaged students, and solutions
Authors: Hale Adrian 
Published: February 2023

This article builds on research, previously published in this journal, which tracked student outcomes in a first year core course in an Australian university over the space of 6 years. That research found that a fundamental shift in educator attitude - away from problematising student disadvantage, to seeing student disadvantage as an opportunity - was essential in activating student motivation and autonomy. Success was measured by student retention, overall grade distributions, and positive student feedback. Viewing student deficits not as the problem, but rather as ‘rich points’, or opportunities for adaptation, is helping to facilitate student success. Indeed, this article asserts that an integral part of finding solutions is the ability to decode student feedback – both positive and negative – as an articulation of what disadvantaged students need most.
Mesenchymal Stem Cells Versus Placebo for Perianal Fistulizing Crohn’s Disease: A Systemic Review and Meta-Analysis
Authors: Li Ang , Liu Sailiang , Li Laiyuan , Yu Minhao 
Published: February 2023

Background Mesenchymal stem cells (MSCs)-based therapy for perianal fistulizing Crohn’s disease (pfCD) has been extensively studies in the past decade. Its efficacy and safety had been preliminarily confirmed in some phase 2 or phase 3 clinical trials. This meta-analysis is performed to evaluate the efficacy and safety of MSCs-based therapy for pfCD. Methods Electronic databases (Pubmed, Cochrane Library, Embase) were searched for studies that reported the efficacy and safety of MSCs. And RevMan were used to assess the efficacy and safety. Results After screening, 5 randomized controlled trials (RCTs) were included in this meta-analysis. RevMan 5.4 for meta-analysis showed that: [Efficacy] Patients had definite remission after MSCs treatment, with an odds ratio (OR) of 2.06 ( P < .0001, 95%CI 1.46, 2.89) vs controls. [Safety] The incidence of the most frequently reported TEAEs (treatment-emergent adverse events, TEAEs), perianal abscess and proctalgia, did not significantly increase due to the use of MSCs, with an OR of 1.07 in perianal abscess ( P = .87, 95%CI 0.67, 1.72) vs controls, and an OR of 1.10 in proctalgia ( P = .47, 95%CI 0.63, 1.92) vs controls. Conclusions MSCs seem to be an effective and safe therapy for pfCD. MSCs based therapy has the potential to be used in combination with traditional therapies.
Diagnostic performance of traditional radiographic indices in detection of carpal collapse in Kienböck’s disease
Authors: Luitjens Johanna , Goller Sophia Samira , Schmitt Rainer , Erber Bernd , Van Schoonhoven Jörg , Hesse Nina 
Published: February 2023

Correctly identifying carpal collapse is important for adequate treatment of Kienböck’s disease. This study aimed to assess the accuracy of traditional radiographic indices in detecting carpal collapse to differentiate between Lichtman stages IIIa and IIIb. In 301 patients, carpal height ratio, revised carpal height ratio, Ståhl index and radioscaphoid angle were measured on plain radiographs by two blinded observers. As a reference standard, Lichtman stages were determined by an expert radiologist using CT and MR imaging. The interobserver agreement was excellent. In the differentiation between Lichtman stages IIIa and IIIb, measurements of indices showed moderate to good sensitivity (0.60–0.95) and low specificity (0.09–0.69) using normal cut-off values from the literature, while receiver operating curve analysis revealed poor area under the curve (58–66%). Traditional radiographic indices showed poor diagnostic performance in detecting carpal collapse in Kienböck’s disease and did not reach sufficient accuracy in the differentiation between Lichtman stages IIIa and IIIb. Level of evidence: III
Glenohumeral Cartilage Thickness: Implications in Prosthetic Design and Osteochondral Allograft Transplantation
Authors: Carlson Charles G. , Chen Andreas , Patterson Kyle , Ablove Robert H. 
Published: February 2023

Objective A complete understanding of the glenohumeral joint anatomy is crucial for osteochondral allograft (OCA) transplantation and prosthetic design. However, existing data on the cartilage thickness distribution are not consistent. This study aims to describe the cartilage thickness distribution at both the glenoid cavity and humeral head in males and females. Design Sixteen fresh cadaveric shoulder specimens were dissected and separated to expose the glenoid and humeral head articular surfaces. The glenoid and humeral head were cut into 5-mm coronal sections. Sections were imaged and cartilage thickness was measured at 5 standardized points on each section. Measurements were analyzed based on age, sex, and regional location. Results For the humeral head, cartilage was thickest centrally (M = 1.77 ± 0.35 mm) and thinnest superiorly and inferiorly (M = 1.42 ± 0.37 mm, 1.42 ± 0.29 mm). At the glenoid cavity, cartilage was thickest in the superior and inferior areas (M = 2.61 ± 0.47 mm, 2.53 ± 0.58 mm) and thinnest centrally (M = 1.69 ± 0.22 mm). Males were found to have thicker cartilage at both the humeral head and glenoid ( P = 0.0014, P = 0.0133). Conclusions Articular cartilage thickness distribution of the glenoid and humeral head is nonuniform and reciprocal in nature. These results can be used to further inform prosthetic design and OCA transplantation. We noted a significant difference in cartilage thickness between males and females. This suggests that the sex of the patient should be taken into consideration when matching donors for OCA transplantation.
New algorithmic approach for easier and faster extended disability status scale calculation
Authors: Fouad Amr M , Abdel Naseer Maged , Farghaly Marwa , Hegazy Mohamed I 
Published: February 2023

Background The traditional paper and pencil method for EDSS calculation (pEDSS) is the cornerstone of multiple sclerosis practice; however, it requires an expert for an accurate calculation, and it takes a lot of time to perform the function scores. A new algorithmic approach (aEDSS) has been developed for easier and faster assessment. Objective To determine if using aEDSS can achieve good inter-rater agreement and save time compared to pEDSS. Subjects and methods This study was conducted on 200 MS patients; EDSS was performed twice for each patient by two neurologists on the same day; one used the pEDSS, and the other used the aEDSS in a random order to test the inter-rater agreement regarding functional system scores and the final EDSS score and to detect the difference in the time needed for calculation between both methods. Results The new algorithmic approach achieved excellent agreement with the traditional method (Kappa > 0.81) with a shorter calculation time (16 ± 2.67 min for aEDSS vs 31 ± 4.3 min for pEDSS, P < 0.0001). Conclusion The new algorithmic approach could represent a suitable alternative to the traditional method, making EDSS calculation easier and faster.
Outcomes After Combined Remnant Preservation and Bone Marrow Stimulation for Acute Rotator Cuff Tears
Authors: Zhou Yi , She Hongjiang , Liu Xiaoyan , Wang Rui , Bai Fan 
Published: February 2023

Background: Both remnant preservation (RP) and bone marrow stimulation (BMS) enhance the healing potential of the repaired rotator cuff by improving the biological milieu of the tendon-bone interface. Purpose: To evaluate the clinical and imaging outcomes of arthroscopic rotator cuff repair using a combined RP-BMS technique in patients with acute rotator cuff tears. Study Design: Cohort study; Level of evidence, 3. Methods: Between January 2016 and June 2019, a total of 56 patients were diagnosed with acute rotator cuff tears; 29 patients underwent conventional repair (group 1), and 27 patients underwent RP-BMS (group 2). At a minimum follow-up period of 2 years, the authors compared clinical outcomes with the University of California–Los Angeles; Constant; American Shoulder and Elbow Surgeons; and pain visual analog scale scores as well as shoulder range of motion. Tendon integrity and retear were assessed on magnetic resonance imaging according to the Sugaya classification (intact, grades 1-3; retear, grades 4-5). Between-group comparisons were conducted using the Student t test or Mann-Whitney U test for continuous variables and the Pearson chi-square test or Fisher exact test for categorical variables. Results: In both groups, patients had significant preoperative to postoperative improvement on all clinical outcome measures ( P = .001 for all). Shoulder abduction in group 2 was significantly greater compared with group 1 at the postoperative 3-month (107.37° ± 8.32° vs 95.44° ± 8.78°; P = .001), 6-month (155.25° ± 10.02° vs 144.72° ± 9.28°; P = .001), and final (165.15° ± 9.17° vs 158.31° ± 8.01°; P = .021) follow-ups. At the final follow-up, significantly more patients in group 2 had intact tendons (Sugaya grades 1-3) compared with group 1 ( P = .015), and the tendon retear rate was lower in group 2 (1/27; 3.70%) than in group 1 (7/29; 24.14%) ( P = .033). Conclusion: Both surgical techniques led to satisfactory clinical outcomes, but shoulder abduction was greater after the RP-BMS technique compared with conventional repair. RP-BMS may be an alternative surgical technique to improve tendon integrity and retear rates after the repair of acute rotator cuff tears.
The sense of stopping migraine prophylaxis
Authors: Al-Hassany Linda , Lyons Hannah S. , Boucherie Deirdre M. , Farham Fatemeh , Lange Kristin S. , Marschollek Karol , Onan Dilara , Pensato Umberto , Storch Elisabeth , Torrente Angelo , Waliszewska-Prosół Marta , Reuter Uwe ,   on behalf of the European Headache Federation School of Advanced Studies (EHF-SAS)
Published: February 2023

AbstractIntroductionMigraine prophylactic therapy has changed over recent years with the development and approval of monoclonal antibodies (mAbs) targeting the calcitonin gene-related peptide (CGRP) pathway. As new therapies emerged, leading headache societies have been providing guidelines on the initiation and escalation of such therapies. However, there is a lack of robust evidence looking at the duration of successful prophylaxis and the effects of therapy discontinuation. In this narrative review we explore both the biological and clinical rationale for prophylactic therapy discontinuation to provide a basis for clinical decision-making.MethodsThree different literature search strategies were conducted for this narrative review. These include i) stopping rules in comorbidities of migraine in which overlapping preventives are prescribed, notably depression and epilepsy; ii) stopping rules of oral treatment and botox; iii) stopping rules of antibodies targeting the CGRP (receptor). Keywords were utilized in the following databases: Embase, Medline ALL, Web of Science Core collection, Cochran Central Register of Controlled Trials, and Google Scholar.DiscussionReasons to guide decision-making in stopping prophylactic migraine therapies include adverse events, efficacy failure, drug holiday following long-term administration, and patient-specific reasons. Certain guidelines contain both positive and negative stopping rules. Following withdrawal of migraine prophylaxis, migraine burden may return to pre-treatment level, remain unchanged, or lie somewhere in-between. The current suggestion to discontinue CGRP(-receptor) targeted mAbs after 6 to 12 months is based on expert opinion, as opposed to robust scientific evidence. Current guidelines advise the clinician to assess the success of CGRP(-receptor) targeted mAbs after three months. Based on excellent tolerability data and the absence of scientific data, we propose if no other reasons apply, to stop the use of mAbs when the number of migraine days decreases to four or fewer migraine days per month.There is a higher likelihood of developing side effects with oral migraine preventatives, and so we suggest stopping these drugs according to the national guidelines if they are well tolerated.ConclusionTranslational and basic studies are warranted to investigate the long-term effects of a preventive drug after its discontinuation, starting from what is known about the biology of migraine. In addition, observational studies and, eventually, clinical trials focusing on the effect of discontinuation of migraine prophylactic therapies, are essential to substantiate evidence-based recommendations on stopping rules for both oral preventives and CGRP(-receptor) targeted therapies in migraine.Graphical Abstract
Ultra-small low-threshold mid-infrared plasmonic nanowire lasers based on n-doped GaN
Authors: Zheng Jiahui , Yan Xin , Zhang Xia , Ren Xiaomin 
Published: February 2023

AbstractAn ultra-small mid-infrared plasmonic nanowire laser based on n-doped GaN metallic material is proposed and studied by the finite-difference time-domain method. In comparison with the noble metals, nGaN is found to possess superior permittivity characteristics in the mid-infrared range, beneficial for generating low-loss surface plasmon polaritons and achieving strong subwavelength optical confinement. The results show that at a wavelength of 4.2 µm, the penetration depth into the dielectric is substantially decreased from 1384 to 163 nm by replacing Au with nGaN, and the cutoff diameter of nGaN-based laser is as small as 265 nm, only 65% that of the Au-based one. To suppress the relatively large propagation loss induced by nGaN, an nGaN/Au-based laser structure is designed, whose threshold gain has been reduced by nearly half. This work may pave the way for the development of miniaturized low-consumption mid-infrared lasers.
Agreement test of P value versus Bayes factor for sample means comparison: analysis of articles from the Angle Orthodontist journal
Authors: Srimaneekarn Natchalee , Leelachaikul Pattamon , Thiradilok Sasipa , Manopatanakul Somchai 
Published: February 2023

Abstract
Background
Researchers are cautioned against misinterpreting the conventional P value, especially while implementing the popular t test. Therefore, this study evaluated the agreement between the P value and Bayes factor (BF01) results obtained from a comparison of sample means in published orthodontic articles.

Methods
Data pooling was undertaken using the modified PRISMA flow diagram. Per the inclusion criteria applied to The Angle Orthodontist journal for a two-year period (November 2016 to September 2018), all articles that utilised the t test for statistical analysis were selected. The agreement was evaluated between the P value and Bayes factor set at 0.05 and 1, respectively. The percentage of agreement and Kappa coefficient were calculated. Plotting of effect size against P value and BF01 was analysed.

Results
From 265 articles, 82 utilised the t test. Of these, only 37 articles met the inclusion criteria. The study identified 793 justifiable t tests (438 independent-sample and 355 dependent-sample t tests) for which the agreement percentage and Kappa coefficient were found to be 93.57% and 0.87, respectively. However, when anecdotal evidence (1/3 < BF01 < 3) was considered, almost half of the studies missed statistical significance. Furthermore, two-thirds of the significantly reported P values (0.01 < P < 0.05; 30 independent-sample and 20 dependent-sample t tests) showed only anecdotal evidence (1/3 < BF01 < 1). Moreover, BF01 indicated moderate evidence (BF01 > 3) for approximately one-third of the total studies, with nonsignificant P values (P > 0.05). Furthermore, accompanying the P values, the effect sizes, especially for studies with independent-sample t tests, were very high with a strong potential to show substantive significance. Although it is best to extend the statistical calculation of a doubted P value (just below 0.05), especially for orthodontic innovation, orthodontists may reach a balanced decision relying on cephalometric measurements.

Conclusions
The Kappa coefficient indicated perfect agreement between the two methods. BF01 restricted this judgement to approximately half of them, with two-thirds of these studies showing nonsignificant P values. Simple extensions of statistical calculations, especially effect size and BF01, can be useful and should be considered when finalising statistical analyses, especially for orthodontic studies without cephalometric analysis.
Dietary fatty acids and endometrial cancer risk within the European Prospective Investigation into Cancer and Nutrition
Authors: Yammine S. G. , Huybrechts I. , Biessy C. , Dossus L. , Panico S. , Sánchez M. J. , Benetou V. , Turzanski-Fortner R. , Katzke V. , Idahl A. , Skeie G. , Olsen K. Standahl , Tjønneland A. , Halkjaer J. , Colorado-Yohar S. , Heath A. K. , Sonestedt E. , Sartor H. , Schulze M. B. , Palli D. , Crous-Bou M. , Dorronsoro A. , Overvad K. , Gurrea A. Barricarte , Severi G. , Vermeulen R. C.H. , Sandanger T. M. , Travis R. C. , Key T. , Amiano P. , Van Guelpen B. , Johansson M. , Sund M. , Tumino R. , Wareham N. , Sacerdote C. , Krogh V. , Brennan P. , Riboli E. , Weiderpass E. , Gunter M. J. , Chajès V. 
Published: February 2023

AbstractBackgroundDiet may impact important risk factors for endometrial cancer such as obesity and inflammation. However, evidence on the role of specific dietary factors is limited. We investigated associations between dietary fatty acids and endometrial cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC).MethodsThis analysis includes 1,886 incident endometrial cancer cases and 297,432 non-cases. All participants were followed up for a mean of 8.8 years. Multivariable Cox proportional hazard models were used to estimate hazard ratios (HR) and 95% confidence intervals (CI) of endometrial cancer across quintiles of individual fatty acids estimated from various food sources quantified through food frequency questionnaires in the entire EPIC cohort. The false discovery rate (q-values) was computed to control for multiple comparisons.ResultsConsumption of n-6 γ-linolenic acid was inversely associated with endometrial cancer risk (HR comparing 5th with 1st quintileQ5−Q1=0.77, 95% CI = 0.64; 0.92, ptrend=0.01, q-value = 0.15). This association was mainly driven by γ-linolenic acid derived from plant sources (HRper unit increment=0.94, 95%CI= (0.90;0.98), p = 0.01) but not from animal sources (HRper unit increment= 1.00, 95%CI = (0.92; 1.07), p = 0.92). In addition, an inverse association was found between consumption of n-3 α-linolenic acid from vegetable sources and endometrial cancer risk (HRper unit increment= 0.93, 95%CI = (0.87; 0.99), p = 0.04). No significant association was found between any other fatty acids (individual or grouped) and endometrial cancer risk.ConclusionOur results suggest that higher consumption of γ-linolenic acid and α-linoleic acid from plant sources may be associated with lower risk of endometrial cancer.
The influence of meteorological factors and total malignant tumor health risk in Wuhu city in the context of climate change
Authors: Pan Zhipeng , Yu Lingxiang , Shao Ming , Ma Yubo , Cheng Yuting , Wu Ye , Xu Shanshan , Zhang Congjun , Zhu Jiansheng , Pan Faming , Sun Guoping 
Published: February 2023

AbstractWith the increasing severity of the malignant tumors situation worldwide, the impacts of climate on them are receiving increasing attention. In this study, for the first time, all-malignant tumors were used as the dependent variable and absolute humidity (AH) was innovatively introduced into the independent variable to investigate the relationship between all-malignant tumors and meteorological factors. A total of 42,188 cases of malignant tumor deaths and meteorological factors in Wuhu City were collected over a 7-year (2014–2020) period. The analysis method combines distributed lagged nonlinear modeling (DLNM) as well as generalized additive modeling (GAM), with prior pre-analysis using structural equation modeling (SEM). The results showed that AH, temperature mean (T mean) and diurnal temperature range (DTR) all increased the malignant tumors mortality risk. Exposure to low and exceedingly low AH increases the malignant tumors mortality risk with maximum RR values of 1.008 (95% CI: 1.001, 1.015, lag 3) and 1.016 (95% CI: 1.001, 1.032, lag 1), respectively. In addition, low and exceedingly low T mean exposures also increased the risk of malignant tumors mortality, the maximum RR was 1.020 (95% CI: 1.006, 1.034) for low T mean and 1.035 (95% CI: 1.014, 1.058) for exceedingly low T mean. As for DTR, all four levels (exceedingly low, low, high, exceedingly high, from low to high) of exposure increased the risk of death from malignant tumors, from exceedingly low to exceedingly high maximum RR values of 1.018 (95% CI: 1.004, 1.032), 1.011 (95% CI: 1.005, 1.017), 1.006 (95% CI: 1.001, 1.012) and 1.019 (95% CI: 1.007, 1.031), respectively. The results of the stratified analysis suggested that female appear to be more sensitive to humidity, while male require additional attention to reduce exposure to high level of DTR.
Participation in screening for breast and cervical cancer among women with current or previous drug use: a survey study
Authors: Garpenhag Lars , Dahlman Disa 
Published: February 2023

Abstract
Background
Women with current or previous drug use (WCPDU) have an increased risk of poor breast and cervical cancer outcomes. Screening is known to decrease the mortality of these common cancer forms, but screening participation has been sparsely investigated among women with drug dependency. The aim of this study was to assess participation in screening for breast and cervical cancer among WCPDU.

Methods
We recruited WCPDU to a survey study, from six opioid substitution treatment (OST) clinics and one needle exchange program (NEP) in Malmö, Sweden, and through the Drug Users Union in Stockholm, Sweden. The survey was constructed according to results from focus group discussions about cancer screening in a sample of women in OST. Survey data were analyzed using descriptive statistics. We analyzed associations between non-compliance to screening and healthcare contact (OST, NEP or none) by logistic regression analysis; unadjusted and adjusted for age, native language, housing situation, educational attainment and main source of income.

Results
A total of 298 women (median age 43 years) responded to the survey. The self-reported compliance with cancer screening recommendations was 29% for breast cancer screening and 41% for cervical cancer screening. Non-compliance with cervical cancer screening was associated with NEP participation in univariate but not multivariate analysis. We did not find an association between non-compliance with breast cancer screening and healthcare contact. Non-compliance with screening for cervical cancer was also associated with unstable housing in univariate and multivariate analyses, and inversely associated with increasing age in a univariate analysis. Non-compliance with breast cancer was associated with unstable housing in a univariate analysis, and inversely associated with not having Swedish as a native language in a multivariate analysis.

Conclusion
The self-reported compliance with the national cancer screening programs for breast cancer and cervical cancer of WCPDU is notably lower than in the Swedish general population. Women with unstable housing seem to be particularly vulnerable to non-compliance with cancer screening. Interventions to minimize barriers to cancer screening are crucial to decrease the increased cancer morbidity and mortality among WCPDU.