bluuebunny/crossref_metadata_2025_split huggingface dataset:
Strontium-substituted phosphate-based glass exhibits improved and optimized bioactive in vitro and in vivo responses
Authors: Ryu Jeong-Hyun , Lee Myung-Jin , Mangal Utkarsh , Seo Ji-Yeong , Jeong Il Jun , Park Jin-Young , Na Ji-Yeong , Lee Kee-Joon , Yu Hyung-Seog , Cha Jae-Kook , Kwon Jae-Sung , Choi Sung-Hwan 
Published: February 2023

Abstract
Background
Phosphate-based glass (PBG) is an attractive bioactive material for promoting the cellular regenerative response. PBG consists of glass network which contains phosphate as the main component and can be substituted into various therapeutic ions. Strontium (Sr) can stimulate osteogenic activity and inhibit the pro-inflammatory response. However, there are limited studies on the characterization and biological performance Sr-substituted PBG (PSr). In this study, PSr was characterized and its of immuno-osteogenic response potential was investigated for substituting Ca with Sr. Considering a priority for cellular activity, we compared the optimized PSr against the benchmark 45S5 bioactive glass (BG) for its effect on cellular bioactive response and regenerative hard tissue.
Methods
PSr groups were fabricated by a melt-quenching method; subsequently, they were characterized and their biological performance was investigated for the preference of PSr. Considering the clinically used BG as the benchmark, PSr was evaluated based on the cytotoxicity assay, osteogenic activity, pro-inflammatory response, and implantation of calvaria bone defect.
Results
PSr groups exhibited a glass structure and phosphate network similar to that of PBG. However, the results of ion release analysis showed that PSr6 was stable in accordance with Ca/P, Ca/Sr, and P/Sr ratios. Based on these results, the cellular response of PSr6 was the highest, which increased for the early osteogenic marker and inhibited the inflammatory response. Compared to the clinically used BG as the benchmark, PSr6 promoted osteogenic activity and suppressed inflammatory response. The results of in vivo study indicated that the new bone formation in the PSr6 was similar to that in benchmark BG. However, the limitation of this study was the four weeks of implantation. However, the results of our study suggest that PSr6 is promising for enhancing the immuno-osteogenic response and regenerating hard tissue with the optimized glass structure having Ca/Sr ratio of 2:1.
Conclusions
The developed PSr6 demonstrated stable physical properties, favorable cytocompatibility, and immune-osteogenic response. Compared with benchmark BG, PSr6 exhibited enhanced immuno-osteogenic response and regeneration of new bone and connective tissues. Therefore, PSr6 is a potential bone grafting material for regenerative hard tissue.
The Mediating Role of Perceptions of Municipal government Performance on the Relationship between Good Governance and Citizens’ Trust
Authors: Abdi Ahmed-Nor Mohamed 
Published: February 2023

AbstractThe study examined whether elements of good governance affect citizens’ trust through citizens’ perceptions of municipal government performance. 357 cross-sectional data were collected from residents of Mogadishu Municipality, Somalia. SmartPLS 4 was used to analyze the data. The study found that perceived elements of good governance positively and directly affect both citizens’ trust and perceptions of municipal government performance. Also, perceptions of municipal government performance partially mediate both variables. The study concludes that municipality officials need to recognize the importance of good governance and citizens’ perceptions of municipal government performance if they want citizens to trust the municipality.
Number of healthy teeth can predict the response of rectal cancer to chemoradiotherapy
Authors: Nakao Toshihiro , Shimada Mitsuo , Yoshikawa Kozo , Tokunaga Takuya , Nishi Masaaki , Kashihara Hideya , Takasu Chie , Wada Yuma , Yoshimoto Toshiaki 
Published: February 2023

Abstract
Background: It has been reported that the oral and gut microbiomes are associated with the prognosis in patients who undergo surgery, chemotherapy, and radiation for colorectal cancer. This study is the first to identify a correlation between the number of healthy teeth, which is an oral health indicator, and the efficacy of preoperative chemotherapy for rectal cancer.
Methods: This retrospective single-center study included 30 patients who underwent radical surgery after preoperative chemoradiotherapy (CRT) between December 2013 and June 2021. The relationship between number of teeth before CRT and the efficacy of CRT, CRT-related adverse events, postoperative complications, and long-term postoperative outcomes was examined.
Results: The number of healthy teeth was significantly greater in patients with downstaging of their disease than in those without downstaging (p=0.027) and in patients with a complete response according to the Response Evaluation Criteria in Solid Tumors than in those who did not have a complete response (p=0.014). Patients were divided into two groups according to whether they had ≥15 teeth or ≤14 teeth. There was no significant between-group difference in CRT-related adverse events. The incidence of all postoperative complications and grade II postoperative complications tended to be higher in patients with ≥15 teeth (p=0.071 and p=0.092, respectively), as did the 5-year overall survival rate (p=0.083) and the 5-year disease-free rate (p=0.007).
Conclusions: The number of healthy teeth predicted the response to preoperative CRT, postoperative complications, and the outcome of subsequent surgery in patients with rectal cancer.
LiangxueJiedu Formula improves psoriatic dermatitis by regulating the circadian clock to inhibit IL-17-producing Th17 and γδT cells
Authors: Xie Xinran , Zhang Lei , Lin Yan , Liu Xin , Han Xuyang , Li Ping 
Published: February 2023

Abstract
Background
Psoriasis is an immune-mediated inflammatory skin disease. The circadian clock influence immune cells and control the skin’s inflammatory response. In this study, we observed the effect of LiangxueJiedu Formula (LXJDF) on imiquimod-induced per2-knockout mice to explore the mechanism of Chinese medicinal herbs in improving skin inflammation via the circadian clock.
Methods
The per2−/− mice were randomly divided into the model group, the LXJDF group, and the positive drug group (dexamethasone). The dorsal skin of mice was smeared with imiquimod at 9:00 AM (ZT1), and the corresponding drugs were given at 10:00AM (ZT2) and 10:00 PM (ZT14), respectively. The wild-type (WT) mice were smeared vaseline as the control group. The skin lesions were observed and PASI was performed for six consecutive days. The pathological morphology of the skin was determined by HE and immunofluorescence (Ki67, loricrin, and IL-17A) staining, and the epidermis thickness was measured. The spleen weight and index were calculated, and the splenocyte subtypes and serum cytokine levels were detected by flow cytometry. The serum melatonin levels were detected by ELISA. The gene expressions of inflammatory cytokines in the skin were determined by qPCR. The gene and protein expressions of circadian clock-related genes (CLOCK, BMAL1, REV-ERBα, NFIL3, and RORγt) in the skin were determined by qPCR and western blot.
Results
LXJDF could significantly improve the psoriasiform skin lesions, including the reduction of PASI, thinning of epidermal thickness, inhibition of keratinocytes proliferation, and parakeratosis at two-time points (ZT2 and ZT14). LXJDF could reduce the spleen weight and index and inhibit the number of Th17 cells, γδT cells, and the serum inflammatory factors levels of IL-17A, IL-17F, TNF-α, IL-22, IL-6. In addition, LXJDF could significantly down-regulate the mRNA expressions of IL-17A, IL-17F, IL-23, and IL-6 in the skin. LXJDF significantly increased the expressions of BMAL1 and REV-ERBα, and decreased NFIL3 and RORγt.
Conclusions
LXJDF ameliorates psoriatic dermatitis by regulating the circadian clock to inhibit IL-17-producing Th17 and γδT cells.
Optimization of multi-objective reliability redundancy allocation problem with non-homogeneous components using mixed redundancy strategy under uncertainty conditions
Authors: Noormohammadi Gholamreza , najafi esmaeil , Safari Jalal , sobhani farzad Movahedi 
Published: February 2023

Abstract
In this paper, we introduce a new multi-objective model and solution method for the reliability-redundancy allocation problem (RRAP) in a series-parallel system to maximize system reliability and minimize total cost. Most studies on RRAP assume the components are homogeneous, the reliability of components is predefined, and redundancy strategies in each subsystem are considered cold-standby or active. Each of the above assumptions serves as a constraint that doesn’t broaden solution regions. In the proposed multi-objective model, the components are heterogeneous, and the reliability of components is uncertain. In addition, mixed strategies (cold-standby and active redundancies) can be used in each subsystem. The proposed optimization problem is an NP-hard problem and cannot be solved by exact algorithms. Therefore, it is necessary to use meta-heuristic algorithms to solve this problem. Since the proposed model is a multi-objective model, a multiple evolutionary algorithm called NSGA-II will be used to solve the problem. Lastly, the performance of the proposed mathematical model is assessed by a well-known problem-testing method. The optimization results show the effectiveness of the proposed model and prove that the proposed method outperforms the previous ones.
Reconsideration of ileocoecal pouch as a neobladder post cystectomy with proximal urethra sparing: extended evaluation of continence and morbidity in 97 patients
Authors: Nassar Omaya 
Published: February 2023

Abstract
Purpose: To reconsider safety and functional sufficiency of ileocoecal pouch (IC) as a neobladder post urethral sparing cystectomy (USC) in a prolonged series. Secondary aim is male to female voiding control.
Materials and methods: (2000-2016), 97 participants (36 females) with bladder and uterine cervix cancer underwent cystectomy / anterior pelvic resection. Entirely open IC was used with modifications to add urethral length. Continence progress and morbidity were evaluated over 68 month (m).Pad-free candidate in-between voiding times beside candidates’ satisfaction were a real continence.
Results: Male total 24 hour control was (36, 59, 73& 70%) after 6, 12 & 24- m and 5-years respectively. Ladies continence was (0, 12.5, 33 & 30%) for the similar time. Stress incontinence was 84% (grade II&III) at 2-m decreased to 49% (grade I) after 5-years. Capacities and voiding volumes significantly elevated 6 - 12 m; but residual volume & compliance didn’t. Females had lower bladder neck and urethral pressures than males even USC and day& night continence were delayed significantly. Female sex and comorbidity were the main factors to delay continence while age & USC were non-significant.
Early complications (20%) were mostly Clavien-grade I & II with 2-mortality and 3-reoperation. Leak was less for USC. Late complications (17.5%) were grade II&III including 4-reoperation without rediversion.
Conclusions: IC is still a safe straightforward technique with adequate compliance and offers consistent rising continence rates with average morbidity and renal preservation. Females may not benefit control for this diversion as males and USC has no significant impact.
Amenable-like and Connes Amenable-like Propertiesof Certain Matrix Algebras
Authors: Shariati Seyedeh Fatemeh , Rostami Mehdi , Sahami Amir 
Published: February 2023

Abstract
In this paper, we study some amenability like properties for certain matrix algebras called anti-symmetric matrix algebras, say $AS_I(\Bbb C)$, where the index set $I$ is a totally ordered set which posses a smallest element. We show that anti-symmetric matrix algebra is biprojective and weakly amenable. We prove that $AS_I(\Bbb C)$ is pseudo-contractible if and only if $I$ is singleton. In the second part of the paper we investigate some amenability like properties for a class of $\ell^{2}$-Munn algebras. As a dual Banach algebra, we study some Connes homological properties of these algebras like Connes biprojectivity and approximate Connes amenability.
Improved Mathematical Models of Parkinson's Disease with Hopf Bifurcation and Huntington's Disease with Chaos
Authors: Elfouly Mohamed 
Published: February 2023

Abstract
Studying mathematical models for Parkinson's disease and Huntington's disease by using delay differential equations is important to clarify the importance of synchronization between different basal ganglia loops. We used the delay circuit RLC (resistor, inductor, capacitor) model to illustrate excitation and inhibition of the motor cortex from the direct pathway and the indirect pathway in the basal ganglia. A term has been added to the mathematical model without time delay in the case of the hyperdirect pathway. It is proposed to add a non-linear term to adjust the synchronization. We studied Hopf bifurcation conditions for the proposed models. The desynchronization of response times between the direct pathway and the indirect pathway leads to different symptoms of Parkinson's disease. Tremor occurs when the time delay in the dopaminergic pathway is increased by the indirect pathway. The simulation confirmed that tremor occurs and the motor cortex is in an inhibited state. If the time delay in the dopaminergic pathway is increased by the direct pathway, this leads to a critical increase in the activity of the motor cortex. The activity of the motor cortex is regulated by the hyperdirect pathway. The simulation showed bradykinesia occurs when we switch from one movement to another that is less exciting for the motor cortex. A decrease of GABA in the striatum or delayed excitation of the substantia nigra from the subthalamus may be a major cause of Parkinson's disease. An increase in the response time delay in one of the pathways results in the chaotic movement characteristic of Huntington's disease.
Sodium-hyaluronate Mouthwash on Radiotherapy-induced Xerostomia: a Randomized Clinical Trial
Authors: Rupe Cosimo , Basco Alessia , Gioco Gioele , Patini Romeo , Lucchese Alberta , Micciché Francesco , Massaccesi Mariangela , Lajolo Carlo 
Published: February 2023

Abstract
Introduction: Radiotherapy-Induced Xerostomia (RIX) is one of the most common adverse effects of Radiotherapy (RT) in the Head and Neck Cancer patients (HNC), and a major determinant of survivors' quality of life. The primary objective was to evaluate the reduction of patients’ xerostomia symptoms after the utilization of a sodium-hyaluronate mouthwash compared to a placebo solution. The secondary objectives were to evaluate the improvement of quality of life, and to evaluate the patients’ satisfaction. Methods: The protocol was approved by the ethical committee (Ref. 50053/19) and registered at ClinicalTrials.gov (ID: NCT05103124). The study was a double-blind randomized clinical trial (RCT) with a crossover design and was conducted the Fondazione Policlinico Universitario A. Gemelli, Rome Results: Thirty-two patients completed the study protocol. Lower values of the modified Xerostomia Questionnaire (XQ) were retrieved when comparing the baseline scores to the ones after treatment, when compared with placebo (Mann-Whitney U test = 0.01); higher values of patients’ satisfaction (Likert Scale) and modified XQ were retrieved for the sodium-hyaluronate mouthwash (Mann-Whitney U test = 0.001). Conclusions: This RCT highlight the advantages of treating RIX with the sodium-hyaluronate mouthwash, since it seems to be clinically effective in reducing its symptoms, without any reported adverse events.
Highly-Excited Rydberg Excitons in Synthetic Thin-Film Cuprous Oxide
Authors: DeLange Jacob , Barua Kinjol , Ohadi Hamid , Paul Anindya , Zwiller Val , Steinhauer Stephan , Alaeian Hadiseh 
Published: February 2023

Abstract
Cuprous oxide (Cu2O) has recently been proposed as a promising solid-state host for excitonic Rydberg states with large principal quantum numbers (n) whose exaggerated wavefunction sizes (∝ n2 ) facilitate gigantic dipole-dipole (∝ n4) and van der Waals (∝ n11) interactions, making them an ideal basis for solid-state quantum technology. Synthetic, thin-film Cu2O samples are of particular interest because they can be made defect-free via carefully controlled fabrication and are, in principle, suitable for the observation of extreme single-photon nonlinearities caused by Rydberg blockade. In this study, we demonstrate the successful synthesis of nanometer-scale thin films of Cu2O on a transparent substrate and present evidence for the presence of Rydberg excitons up to n = 8. These results represent a significant step towards the development of scalable and integrable Rydberg-based quantum devices on a chip.
Effect of metals doped TiO2 composite on degradation of methylene blue
Authors: Farooq Saima , Dawery Salam Kadhim Al , Annamareddy Sri Hari Kumar , Shukri Asila Abdulaziz Al. , Ryami Khamis Al. , Yaaqubi Fatema Abdullah Al. , Dawary Muataz S. Al 
Published: February 2023

Abstract
Many types of organic compounds are being discharged in ever-increasing quantities into the environment. In the present work, catalysts composed of titanium dioxide and metals with the presence of ultraviolet light or visible light are used for the degradation of organic contaminants. Single and dual metals (Fe+ 3 and Co+ 2) doped TiO2 were prepared using sol-gel method and wet impregnation methods for the degradation of the methylene blue. The composition and morphology of the prepared catalysts were analyzed using EDX and SEM techniques. The results demonstrated that iron and cobalt are dispersed on the surface and between the interfaces of the TiO2. The diameter of pure TiO2 nanoparticles was 54 nm, while that of Fe-and Co doped TiO2 nanoparticles were 45.6 and 38 nm respectively. The results showed that the degradation of methylene blue using different prepared catalysts were: 80% using pure 500ppm TiO2 with UV irradiation; 60% and 70% using sol-gel 1 g Fe doped 1 g TiO2 with UV and visible lights respectively; 90% and 50% using sol-gel 1 g Fe doped 2 g TiO2 with UV and visible lights respectively. For the case of prepared catalyst by wet impregnation metal- TiO2, the degradation of methyl blue were; 50% and 35% using Fe- TiO2 with UV and visible lights respectively; 50% using Co-TiO2 with both UV and normal lights. However, combing Fe-Co-TiO2 gave 30% degradation with both UV and visible lights. These results indicates that the addition of metals to the TiO2 can improve the degradation of organic materials using visible light irradiation which is impossible with pure TiO2.
Novel quinoxaline core-conjugated microporous polymer coating for highly sensitive solid-phase microextraction of phthalate esters in liquid food samples
Authors: Xiang Gang , Li Wenzhuo , Nong Qiuxiang , He Xiansen , Zhang Cuizhong , Zhang Zhengfa , Huang Wei , Peng Jinyun , Xu Jiangfen , Tan Yiqiu , Sun Jing 
Published: February 2023

Abstract
Conjugated microporous polymers (CMPs) have been widely used in various fields as a new class of porous materials. In this study, a quinoxaline-based CMP (BQP-CMP) was prepared and used as the coating in SPME for the extraction and enrichment of nine phthalate esters (PAEs) in juice, soya sauce, cooking wine, and blended edible oil samples. Several parameters affecting solid-phase microextraction (SPME) were optimized. The feasibility of the developed method was verified using real samples, which showed low LODs (0.014–0.032µg L− 1), wide linearities (0.05–50 µg L− 1), good repeatability (2.8–6.6%), and a long service life. The real liquid samples were successfully analyzed using this proposed method and spiked recoveries of 70.16–96.36% were obtained. Moreover, the interaction model and binding energies between BQP-CMP and the PAEs were explored using molecular docking. A satisfactory extraction efficiency was achieved owing to the high specific surface area (601.62 m2 g− 1), high hydrophobicity, and the conjugated planar structural unit distribution of BQP-CMP. This study demonstrates that BQP-CMP is excellent as a rapid and sensitive analysis material for PAEs at trace levels in various types of samples and that CMP materials are also excellent candidates for SPME coatings.
Prediction model of short-term passenger flow of urban rail transit trains integrating temporal and spatial features
Authors: Zuo Jing , Yu Zhao , Liu Guo Yan , He Ming 
Published: February 2023

Abstract
The diversification of transportation organization mode under the condition of network brings great challenges to the operation of urban rail transit system. Effectively predicting the short-term passenger flow state of trains is an important prerequisite to optimize the transportation strategy and cope with the real-time passenger flow fluctuation. Hence a prediction method of short-term passenger flow of urban rail trains based on GCN and BiLSTM is proposed. Firstly, the time sequence diagram is esablished based on the urban rail transit network, the dynamic spatial correlation between the stations is captured by GCN. secondly, the BiLSTM network is constructed to extract the continuity and periodic time change features of train passenger flow from the forward and backward dimensions. Finally, the spatio-temporal features are stitched together based on the feature fusion network. The performance verification and analysis based on Chengdu Metro show that compared with several baseline models, the proposed model has higher detection accuracy, and the prediction efficiency can fully meet the timeliness requirements of the field, which has a good application prospect.
Geochemistry of an intercalated unit of arkose and shale of the Dhandraul Formation belonging to the Vindhyan Supergroup, Eastern India: Insights from provenance, depositional environment, and geodynamic set-up
Authors: Yadav Pawan Kumar , Das Manorama 
Published: February 2023

Abstract
In this study, we have presented a hitherto unreported mappable member of an intercalated unit of arkose and shale of the Dhandraul Formation of the Kaimur Group exposed in Kaimur district, Bihar, India which was not reported by earlier workers in the Vindhyan basin. It is a contribution for understanding the possible provenance, source area weathering, depositional environment, and geodynamic set-up of this member. Based on field characteristics and petrography study, three lithofacies units have been identified viz. (i) coarse to medium-grained arkose, (ii) intercalated sequence of arkose and shale, and (iii) shale. Geochemically, these lithofacies predominantly occupied the field of arkose and shale except samples fall in the field of sub-arkose. These lithofacies display relatively an enrichment of SiO2 and Al2O3 and show low concentrations of MgO, CaO, Na2O, K2O, and TiO2. The values of ∑REE in arkose are varying from 78.74 to 128.81 ppm whereas the values of fractionation indicate (La/Sm)N (3.73-4.22), (La/Yb)N (7.33-15.59), (Gd/Yb)N (1.32-2.30), and Eu/Eu* (0.58-0.66). In shale, ∑REE ranges from 354.02 to 382.11 ppm while the fractionation contents of (La/Sm)N, (La/Yb)N, and (Gd/ Yb)N, and Eu/Eu* are ranging from 3.82 to 4.82, 7.65 to 11.85, 1.38 to 1.73, and 0.56 to 0.81. On the basis of rock fragments and paleocurrent direction, the possible sources are presumed to be the Chhotanagpur Gneissic Complex and the Mahakoshal Group of rocks, which lie towards the south and southwest. In the binary and ternary plots, most of the samples of arkose and shale have mostly occupied the field of passive margin tectonic setting except one sample comes in the field of the continental island arc. Based on mineralogical and textural maturity, sedimentary structures and the overall sequence of these lithofacies from sandstone to shale member of the Dhandraul Formation show fining upward sequence which attributes the deposition in a shallow coastal fluvial-marine environment in a transgressive phase. This discovery has opened a new opportunity to relook at the depositional environment of the Dhandraul Formation in other parts of the Vindhyan basin.