bluuebunny/crossref_metadata_2025_split huggingface dataset:
Time-varying dependence and currency tail risk during the Covid-19 pandemic
Authors: Gobbi Fabio , Mulinacci Sabrina 
Published: July 2023

Purpose
The purpose of this paper is to introduce a generalization of the time-varying correlation elliptical copula models and to analyse its impact on the tail risk of a portfolio of foreign currencies during the Covid-19 pandemic.

Design/methodology/approach
The authors consider a multivariate time series model where marginal dynamics are driven by an autoregressive moving average (ARMA)–Glosten-Jagannathan-Runkle–generalized autoregressive conditional heteroscedastic (GARCH) model, and the dependence structure among the residuals is given by an elliptical copula function. The correlation coefficient follows an autoregressive equation where the autoregressive coefficient is a function of the past values of the correlation. The model is applied to a portfolio of a couple of exchange rates, specifically US dollar–Japanese Yen and US dollar–Euro and compared with two alternative specifications of the correlation coefficient: constant and with autoregressive dynamics.

Findings
The use of the new model results in a more conservative evaluation of the tail risk of the portfolio measured by the value-at-risk and the expected shortfall suggesting a more prudential capital allocation policy.

Originality/value
The main contribution of the paper consists in the introduction of a time-varying correlation model where the past values of the correlation coefficient impact on the autoregressive structure.
Identifying and categorizing influencers on Instagram with eye tracker
Authors: Jánská Michaela , Žambochová Marta , Vacurová Zuzana 
Published: July 2023

PurposeThis paper aims to explore the recognition and success of different ways of branding native advertising in influencer marketing.Design/methodology/approachThe data are evaluated using statistical tests, correlation and cluster analysis.FindingsIt was found that the higher the recognition rate of a post tagged in a particular way, the better the tagging method for influencer marketing on Instagram. Based on the findings of this study, word tag is recommended first because it is flexible and has one of the highest recognition rates.Research limitations/implicationsThe generalizability of the results across different regional settings requires further investigation.Practical implicationsGood labeling of native advertising leads to greater success.Originality/valueThis study can be used by marketing managers, advertisers and influencers to gain insight into the issue, as well as to better select the appropriate labeling method for their advertising content.
Importance of PLD2 in an IL‐23 driven psoriasiform dermatitis model and potential link to human psoriasis
Authors: Su Zhi , Slivka Peter , Paulsboe Stephanie , Chu Katherine , Wetter Joseph B. , Namovic Marian , Perron Denise , Kannan Arun , Wan Qi , Manning Charlene , Todorovic Viktor , Smith Kathleen M. , Lipovsky Alex , Wang Yibing , Frank Kristine , McGaraughty Steve , Loud Jacqueline , Scott Victoria E. , Honore Prisca , Goedken Eric R. 
Published: July 2023

AbstractPhospholipase D2 (PLD2), a major isoform of the PLD family, has been reported to regulate inflammatory responses. Thus far, the relevance of PLD2 in psoriasis, an inflammatory skin disease, has not been explored. In the current study, we examined PLD2 expression in the skin of psoriasis patients and the role of PLD2 in an interleukin (IL)‐23‐induced mouse model of psoriasiform dermatitis. Both in situ hybridization and bulk RNA sequencing showed PLD2 gene expression is significantly higher in lesional relative to non‐lesional skin of psoriasis patients or the skin of healthy subjects. PLD2 expression is also enriched in residual lesions from patients on biologic therapies. Murine in vivo studies showed that PLD2 deficiency significantly reduced psoriasiform inflammation in IL‐23‐injected ears, as reflected by decreases in ear thickness, expression of defensin beta 4A and the S100 calcium binding protein A7A, macrophage infiltrate, and expression of CXCL10 and IL‐6. However, the expression of type 17 cytokines, IL‐17A and IL‐17F, were not reduced. Dual knockout of PLD1 and PLD2 offered little additional protection compared to PLD2 knockout alone in the IL‐23 model. In addition, pharmacological inhibition with a pan‐PLD1/PLD2 inhibitor also suppressed IL‐23‐induced psoriasiform dermatitis. Bone‐marrow‐derived macrophages from wild type (WT) and PLD2 knockout (KO) mice exhibited little difference in viability and sensitivity to lipopolysaccharide and/or interferon gamma, or resiquimod (R848). PLD2 deficiency did not alter the differentiation and function of Th17 cells in an ex vivo study with splenocytes isolated from WT and PLD2 KO mice. Overall, these data suggest that PLD2 may play a role in the pathophysiology of psoriasis. Reducing macrophage infiltrate and cytokine/chemokine production might contribute to an anti‐inflammatory effect observed in PLD2 knockout mice. Further studies are required to better understand the mechanisms by which PLD2 contributes to skin lesions in psoriasis patients and psoriasiform dermatitis models.
Functional diversity buffers biomass production across variable rainfall conditions through different processes above‐ versus below‐ground
Authors: Aoyama Lina , Shaw E. Ashley , White Caitlin T. , Suding Katherine N. , Hallett Lauren M. 
Published: July 2023

Abstract

Understanding precipitation controls on functional diversity is important in predicting how change in rainfall patterns will alter plant productivity in the future. Trait‐based approaches can provide predictive knowledge about how certain species will behave and interact with the community. However, how functional diversity relates to above‐ and below‐ground biomass production in variable rainfall conditions remains unclear.

Here, we tested the role of mass ratio and niche complementarity hypotheses in shaping above‐ and below‐ground biomass–functional diversity relationships in seasonal drought. We implemented a fully crossed experiment that manipulated drought timing (fall dry, spring dry, consistent dry and ambient rainfall) and community composition (grass‐dominated, forb‐dominated and mixed grass–forb) in a California annual grassland.

Plant communities with mixed functional groups showed higher above‐ and below‐ground biomass than either the grass‐ or forb‐dominant communities.

We found divergent functional diversity–biomass relationships for above‐ and below‐ground biomass. Above‐ground biomass decreased with community weighted means (CWMs) of specific leaf area (SLA) and height, supporting the mass ratio hypothesis, which posits that dominant species with specific traits drive biomass production of the community. Below‐ground biomass showed no evidence of either mass ratio hypothesis or niche complementarity.

While biomass was largely unaffected by the timing of drought in one season, we found community‐wide functional trait shifts in response to rainfall treatments. Above‐ground traits shifted to higher SLA in consistent dry compared to ambient. Below‐ground traits shifted to longer, finer and denser roots in fall and consistent dry, and shorter and coarser roots in spring dry. Functional diversity buffered biomass production by enabling shifts in above‐ and below‐ground functional traits across variable rainfall conditions.

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Widows, Violence and Death: The Construction of Imperial Identity and Memory by Women in Mourning across British India, 1857–1926
Authors: Smith Ellen 
Published: July 2023

AbstractThis article examines the work of British widows in the construction of their husbands’ memory following their violent deaths in British India, during the nineteenth and early‐twentieth centuries. Exploring the collections of a military, missionary and Indian Civil Service widow, it suggests that a specifically feminised culture of mourning nurtured imperial narratives. It moves between personal correspondence, to published accounts of frontier ‘murders’, to a new understanding of South Asian ‘condolence meetings’ and resolutions addressed to British widows, arguing that women were critical to the fashioning of men's identity in death and a broader colonial politics of grief.
Towards sustainable Cleaning‐in‐Place (CIP) in dairy processing: Exploring enzyme‐based approaches to cleaning in the Cheese industry
Authors: Pant Karan J. , Cotter Paul D. , Wilkinson Martin G. , Sheehan Jeremiah J. 
Published: July 2023

AbstractCleaning‐in‐place (CIP) is the most commonly used cleaning and sanitation system for processing lines, equipment, and storage facilities such as milk silos in the global dairy processing industry. CIP employs thermal treatments and nonbiodegradable chemicals (acids and alkalis), requiring appropriate neutralization before disposal, resulting in sustainability challenges. In addition, biofilms are a major source of contamination and spoilage in dairy industries, and it is believed that current chemical CIP protocols do not entirely destroy biofilms. Use of enzymes as effective agents for CIP and as a more sustainable alternative to chemicals and thermal treatments is gaining interest. Enzymes offer several advantages when used for CIP, such as reduced water usage (less rinsing), lower operating temperatures resulting in energy savings, shorter cleaning times, and lower costs for wastewater treatment. Additionally, they are typically derived from natural sources, are easy to neutralize, and do not produce hazardous waste products. However, even with such advantages, enzymes for CIP within the dairy processing industry remain focused mainly on membrane cleaning. Greater adoption of enzyme‐based CIP for cheese industries is projected pending a greater knowledge relating to cost, control of the process (inactivation kinetics), reusability of enzyme solutions, and the potential for residual activity, including possible effects on the subsequent product batches. Such studies are essential for the cheese industry to move toward more energy‐efficient and sustainable cleaning solutions.
A novel whole peanut butter refined by stirred media mill: The size, microstructure, rheology, nutrients, and flavor
Authors: Li Changhong , Dai Taotao , Deng Lizhen , Shuai Xixiang , He Xiaohong , Li Ti , Liu Chengmei , Chen Jun 
Published: July 2023

AbstractA novel whole peanut butter (PB) was developed using an emerging technology called stirred media mill (SMM). The impact of SMM on the size, microstructure, rheology, nutrient, and flavor of PB was investigated. The SMM treatment significantly decreased the particle size of PB, damaged cell structure, and released the oil body from cells. The apparent viscosity of PB decreased with the grinding process. Visual inspection revealed that the colloidal stability of PB was improved. The fatty acid composition was not affected by the grinding process. However, the tocopherol contents of the extracted oil slightly increased. Electronic nose and GC–MS analysis indicated that SMM could alter the flavor of PB after grinding for 45 min. Overall, SMM was a potential process technology to manufacture stable nut butter with smooth texture and delightful flavor profile.
B‐vitamins and heat processed fermented starchy and vegetable foods in sub‐Saharan Africa: A review
Authors: Padonou Sègla Wilfrid , Houngbédji Marcel , Hounhouigan Mênouwesso Harold , Chadare Flora Josiane , Hounhouigan Djidjoho Joseph 
Published: July 2023

AbstractMicronutrient deficiency still occurs in sub‐Saharan Africa (SSA) despite the availability of several food resources, particularly fermented foods and vegetables, with high nutritional potential. Fermentation enhances the quality of food in several aspects. Organoleptically, certain taste, aroma, and textures are developed. Health and safety are improved by inhibiting the growth of several foodborne pathogens and removing harmful toxic compounds. Furthermore, nutrition is enhanced by improving micronutrient contents and bioavailability from the food, especially vitamin B content. However, during processing and before final consumption, many fermented foods are heat treated (drying, pasteurization, cooking, etc.) to make the food digestible and safe for consumption. Heat treatment improves the bioavailability of B‐vitamins in some foods. In other foods, heating decreases the nutritional value because some B‐vitamins are degraded. In SSA, cooked starchy foods are often associated with vegetables in household meals. This paper reviews studies that have focused fermented starchy foods and vegetable foods in SSA with the potential to provide B‐vitamins to consumers. The review also describes the process of the preparation of these foods for final consumption, and techniques that can prevent or lessen B‐vitamin loss, or enrich B‐vitamins prior to consumption.
Nutritional and volatile profiles of pulp and flavedo from four local pummelo cultivars grown in Fujian province of China
Authors: Zhou Jinyu , Kong Lingchao , Li Debao , Zhang Xinxin , Fu Zhijun , Pan Tengfei , Yu Yuan 
Published: July 2023

AbstractThe nutritional and volatile profiles of pulp and flavedo samples from four distinct local pummelo landraces (“Siji,” “Pingshan,” “Wendan,” and “Guanxi”) cultivated in Fujian province of China were investigated. “Guanxi” pummelo exhibited relatively high contents of vitamin C (42.01 mg/100 mL) and phenols (360.61 mg/L) and displayed a robust antioxidant capacity (41.15 mg/100 mL). Conversely, the red pulp from “Pingshan” demonstrated relatively high values of carotenoids (55.96 µg/g) and flavonoids (79.79 mg/L). Considerable differences were observed in volatile compositions between the two fruit tissues and among the four genotypes. A total of 166 and 255 volatile compounds were detected in the pulp and flavedo samples, respectively. Notably, limonene and β‐myrcene were identified as the principal volatile compounds in flavedo, whereas hexanal was highly abundant in the pulp of “Siji,” “Pingshan,” and “Guanxi.” “Wendan” displayed distinct separation from the other three pummelo cultivars in principal component analysis based on the pulp volatile compositions. This distinction was attributed to the higher number and content of volatile compounds in “Wendan” pulp, particularly the remarkable enrichment of β‐myrcene. The newly characterized pummelo landraces and genotype/tissue‐dependent variations in volatiles provide essential information for the genetic improvement of pummelo aroma, as well as for fruit processing and utilization.
Inulin–whey protein as efficient vehicle carrier system for chlorophyll: Optimization, characterization, and functional food application
Authors: Agarry Israel Emiezi , Ding Desheng , Cai Tian , Wu Zhulian , Huang Pimiao , Kan Jianquan , Chen Kewei 
Published: July 2023

AbstractNatural chlorophylls mostly found in vegetables such as spinach (Spinacia oleracea) could be employed as a possible substitute for synthetic colorants because of their intense green properties. However, the stability of natural chlorophyll is a major challenge to its utilization in the food industry. In this study, spray drying as an encapsulation technique was used to improve the stability of natural chlorophyll. Box–Behnken design was utilized to optimize the spray drying conditions for chlorophyll. Optimum conditions were given as inlet temperature, 132°C; inulin‐to‐whey protein isolate ratio, 61%:39%; pump rate, 25%, resulting in 92.3% encapsulation efficiency, 69.4% solubility, and −13.5 mV zeta potential at a desirability level of 0.901. The particle size, Carr index, bulk and tapped density, polydispersity index, and color showed satisfactory results. Crystallinity, endothermic peak melting temperature, and the enthalpy of chlorophyll‐loaded microcapsules increased when compared to the blank microcapsules suggesting decreased hygroscopicity and enhanced thermal stability. In addition, the suitability of fabricated microcapsules using yogurt as a food model was assessed. Yogurt incorporated with chlorophyll‐loaded microcapsules showed no significant pH modification with better apparent viscosity than control and sodium copper chlorophyllin (SCC) yogurt after 9 days of refrigerated storage. Based on the studied responses, the spray drying process could be optimized to achieve optimal output and product quality.Practical ApplicationSpray drying is a cheap and convenient approach for microencapsulating bioactive compounds such as chlorophyll. However, the physico‐chemical and functional properties of the spray‐dried microcapsules are influenced by operating conditions, such as inlet temperature, type and concentration of wall materials, and feed flow rate. Therefore, to maximize and obtain a superior quality of the final product, there is a need to optimize the spray drying process. The Box–Behnken design employed in this study could be utilized as an appropriate technique to design, enhance, and develop process parameters for the fabrication and better retention of the physico‐chemical properties of spray‐dried chlorophyll microcapsules.
Arthropods are kin: Operationalizing Indigenous data sovereignty to respectfully utilize genomic data from Indigenous lands
Authors: Hutchins Leke , Mc Cartney Ann , Graham Natalie , Gillespie Rosemary , Guzman Aidee 
Published: July 2023

AbstractIndigenous peoples have cultivated biodiverse agroecosystems since time immemorial. The rise of metagenomics and high‐throughput sequencing technologies in biodiversity studies has rapidly expanded the scale of data collection from these lands. A respectful approach to the data life cycle grounded in the sovereignty of indigenous communities is imperative to not perpetuate harm. In this paper, we operationalize an indigenous data sovereignty (IDS) framework to outline realistic considerations for genomic data that span data collection, governance, and communication. As a case study for this framework, we use arthropod genomic data collected from diversified and simplified farm sites close to and far from natural habitats within a historic Kānaka ʻŌiwi (Indigenous Hawaiian) agroecosystem. Diversified sites had the highest Operational Taxonomic Unit (OTU) richness for native and introduced arthropods. There may be a significant spillover effect between forest and farm sites, as farm sites near a natural habitat had higher OTU richness than those farther away. We also provide evidence that management factors such as the number of Polynesian crops cultivated may drive arthropod community composition. Through this case study, we emphasize the context‐dependent opportunities and challenges for operationalizing IDS by utilizing participatory research methods, expanding novel data management tools through the Local Contexts Hub, and developing and nurturing community partnerships—all while highlighting the potential of agroecosystems for arthropod conservation. Overall, the workflow and the example presented here can help researchers take tangible steps to achieve IDS, which often seems elusive with the expanding use of genomic data.
An empirical test of the estimation of historical effective population size using Drosophila melanogaster
Authors: Novo Irene , Pérez‐Pereira Noelia , Santiago Enrique , Quesada Humberto , Caballero Armando 
Published: July 2023

AbstractThe availability of a large number of high‐density markers (SNPs) allows the estimation of historical effective population size (Ne) from linkage disequilibrium between loci. A recent refinement of methods to estimate historical Ne from the recent past has been shown to be rather accurate with simulation data. The method has also been applied to real data for numerous species. However, the simulation data cannot encompass all the complexities of real genomes, and the performance of any estimation method with real data is always uncertain, as the true demography of the populations is not known. Here, we carried out an experimental design with Drosophila melanogaster to test the method with real data following a known demographic history. We used a population maintained in the laboratory with a constant census size of about 2800 individuals and subjected the population to a drastic decline to a size of 100 individuals. After a few generations, the population was expanded back to the previous size and after a few further generations again expanded to twice the initial size. Estimates of historical Ne were obtained with the software GONE both for autosomal and X chromosomes from samples of 17 individuals sequenced for the whole genome. Estimates of the historical effective size were able to infer the patterns of changes that occurred in the populations showing generally good performance of the method. We discuss the limitations of the method and the application of the software carried out so far.
Circular RNA circ_0000376 promotes paclitaxel resistance and tumorigenesis of non‐small cell lung cancer via positively modulating KPNA4 by sponging miR‐1298‐5p
Authors: Hu Sheng , Zhang Qun , Sun Jian , Xue Jinshan , Wang Can 
Published: July 2023

AbstractBackgroundCirc_0000376 could promote non‐small cell lung cancer (NSCLC) progression; however, the role of circ_0000376 in paclitaxel (PTX) resistance of NSCLC is still unknown.MethodsQuantitative real‐time polymerase chain reaction (qRT‐PCR) and western blot were applied for measuring circ_0000376, microRNA‐1298‐5p (miR‐1298‐5p), and karyopherin subunit alpha 4 (KPNA4) expression. The half inhibitory concentration (IC50) of PTX was assessed by cell counting kit‐8 assay. 5‐ethynyl‐2′‐deoxyuridine assay, wound healing assay, transwell assay, and flow cytometry were performed to measure the proliferation, migration, invasion, and apoptosis of cells. The regulatory mechanisms of circ_0000376, miR‐1298‐5p, and KPNA4 were validated by dual‐luciferase reporter assay, RNA immunoprecipitation assay, and rescue experiments. Xenograft assay was used for the functional analysis of circ_0000376 in vivo.ResultsCirc_0000376 and KPNA4 expressions were upregulated, while miR‐1298‐5p expression was downregulated in PTX‐resistant tissues and cells. Circ_0000376 depletion promoted PTX sensitivity and apoptosis, while suppressing the proliferation, migration, and invasion of PTX‐resistant NSCLC cells. Furthermore, circ_0000376 could modulate KPNA4 expression by sponging miR‐1298‐5p. Rescue experiments showed that miR‐1298‐5p inhibition reversed the circ_0000376 depletion‐mediated anticancer effects and PTX sensitivity. Moreover, miR‐1298‐5p inhibited PTX resistance and tumorigenesis of PTX‐resistant cells, which were abolished by KPNA4 overexpression. In addition, circ_0000376 knockdown suppressed tumor growth and enhanced PTX sensitivity in vivo.ConclusionCirc_0000376 facilitated PTX resistance and tumorigenesis of NSCLC by miR‐1298‐5p/KPNA4 axis, suggesting an underlying therapeutic strategy for NSCLC.