bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence of periodontitis in dentate people between 2011 and 2020: A systematic review and meta‐analysis of epidemiological studies
Authors: Trindade Diogo , Carvalho Rui , Machado Vanessa , Chambrone Leandro , Mendes José João , Botelho João 
Published: January 2023

AbstractAimThe aim of the study was to evaluate the prevalence of periodontitis in dentate people between 2011 and 2020.Materials and MethodsPUBMED, Web of Science, and LILACS were searched up to and including December 2021. Epidemiological studies reporting the prevalence of periodontitis conducted between 2011 and 2020 were eligible for inclusion in this review. Studies were grouped according to the case definition of confidence as confident (Centers for Disease Control [CDC] AAP 2012; CDC/AAP 2007; and Armitage 1999) and non‐confident (community periodontal index of 3 or 4, periodontal pocket depth >4 mm, and clinical attachment level ≥1 mm). Random effects meta‐analyses with double arcsine transformation were conducted. Sensitivity subgroup and meta‐regression analyses explored the effect of confounding variables on the overall estimates.ResultsA total 55 studies were included. The results showed a significant difference, with confident case definitions (61.6%) reporting nearly twice the prevalence as non‐confident classifications (38.5%). Estimates using confident periodontal case definitions showed a pooled prevalence of periodontitis of 61.6%, comprising 17 different countries. Estimates reporting using the CDC/AAP 2012 case definition presented the highest estimate (68.1%) and the CDC/AAP 2007 presented the lowest (48.8%). Age was a relevant confounding variable, as older participants (≥65 years) had the highest pooled estimate (79.3%).ConclusionBetween 2011 and 2020, periodontitis in dentate adults was estimated to be around 62% and severe periodontitis 23.6%. These results show an unusually high prevalence of periodontitis compared to the previous estimates from 1990 to 2010.
Data simulation to forecast the outcomes of the FAVOR III China trial
Authors: Wang Yang , Song Lei , Guan Changdong , Zhao Yanyan , Chen Ge , Li Wei , Tu Shengxian , Qiao Shubin , Kirtane Ajay J. , Xu Bo 
Published: January 2023

AbstractBackgroundFAVOR III China (F3C) is a large‐scale randomized trial comparing QFR‐guided and angiography‐guided percutaneous coronary intervention (PCI) strategies. The aim of current study was to assess the feasibility of predicting the 1‐year outcomes of the F3C trial using simulation of retrospectively assessed quantitative flow ratio (QFR) data obtained from the all‐comers PANDA III trial.MethodsAmong 2348 subjects from the PANDA III trial, angiography from 1391 patients was able to be analyzed with QFR. Each subject from the F3C was matched to a PANDA III patient according to the five baseline characteristics (age, sex, diabetes, multivessel disease, and existence of any vessel with diameter stenosis % >90% and thrombolysis in myocardial infarction flow <3) through a bootstrapping sampling process. Outcome predictions were based on these blinded baseline data. The primary endpoint was a composite of death, myocardial infarction, or revascularization at 1 year.ResultsAmong the patients with analyzable QFR, 814 patients were able to be matched to F3C patients undergoing a QFR‐guided treatment strategy. After 10,000 simulations, the patients in the QFR‐guided group were simulated to have a 1.9% (95% predictive intervals: –3.5% to –0.3%) absolute reduction of the occurrence of the primary study endpoint compared with the angiography‐guided group. In total, 72.7% (7266/10,000) simulated point estimates fell within the actual 95% CI of F3C (–4.7% to –1.4%).ConclusionsUsing a simulation process based on a comparison to an existing trial cohort, the primary results of a prospectively conducted randomized controlled trial could be predicted with reasonable precision.
Copy–paste concept: Full digital approach in the management of gingival emergence profiles
Authors: Agnini Alessandro , Romeo Davide , Giulia Benedetti , Tommaso Weinstein , Christian Coachman , Agnini Andrea 
Published: January 2023

AbstractObjectiveObtaining a perfect integration of a prosthetic rehabilitation on natural teeth and implantys in the esthetic zone requires a deep knowledge of the biological processes and a clear understanding of the characteristics of the restorative materials. Once the soft tissue profile has been created with the placement of a temporary prosthesis, the ability to accurately transfer information about the tissue profile and the contour of the restoration for the fabrication of the definitive crowns can be challenging.Clinical SignificanceThis paper illustrate the copy paste full digital workflow, a simple protocol that allows to create definitive restorations by making an exact copy of the temporary prosthesis that has been placed in function in the patient's mouth.
Smart care for dealing with nurses' alarm fatigue in the intensive care unit
Authors: Movahedi Ali , Sadooghiasl Afsaneh , Ahmadi Fazlollah , Vaismoradi Mojtaba 
Published: January 2023

AbstractBackgroundAlarm fatigue is a condition in which a person experiences sensory overload or desensitization in exposure to frequent non‐actionable alarms. Nurses are the main users of alarms in health care and their behaviors for alarm management influence the occurrence of alarm fatigue.ObjectivesThis qualitative research aimed to explore strategies used by nurses in dealing with nurses' alarm fatigue in the intensive care unit (ICU).DesignQualitative research was carried out. Eighteen nurses working in ICUs were selected purposefully and were invited to take part in individual semi‐structured interviews. Collected data were analyzed using content analysis for developing categories and subcategories.SettingTwelve ICUs in ten hospitals in four urban areas of Iran.ResultsThe research's main category was “smart care” consisting of two categories of “technologic actions” and “non‐technologic actions.” Also, six subcategories were developed: “identifying the cause and taking timely actions”, “personalized alarm settings”, “reducing the number of unnecessary alarms”, “effective teamwork”, “improving the physical environment and ward arrangement”, and “self‐calmness”.ConclusionSmart care by nurses included a set of active and proactive interventions developed through thinking and reflection and the use of information, skills, and experiences in order to manage exposure to alarm fatigue. Strategies used by nurses to prevent alarm fatigue can reduce the physical and psychological burden caused by frequent exposure to alarms in the ICU and consequently can have direct impacts on the quality and safety of nursing care.Clinical RelevanceNurses in the healthcare process often experience alarm fatigue that is influenced by the cultural‐contextual aspect of care and the care environment. Smart care in terms of technologic and non‐technologic actions helps with the prevention of alarm fatigue.
Current state of management of struma ovarii and preoperative imaging features: A retrospective case series study of 18 patients at a single institution
Authors: Tamura Nami , Murakami Keisuke , Ozaki Rie , Takeuchi Shiori , Ochiai Asako , Kawasaki Yu , Okada Yukiko , Kitade Mari , Itakura Atsuo 
Published: January 2023

AbstractAimEven though 95% of struma ovarii are benign, it is often overtreated because of the difficulty to distinguish it from malignancy. In this study, our aim was to evaluate the current state of the preoperative diagnosis and the selection of the surgical procedure, and to improve preoperative diagnostic accuracy by retrospectively reviewing imaging findings.MethodsWe retrospectively reviewed the clinical course and imaging characteristics of 18 patients who were diagnosed postoperatively with struma ovarii, pathologically, at our institution between 2015 and 2021.ResultsThe preoperative diagnoses included benign ovarian tumor in eight cases, borderline in four cases, and malignant in six cases. None of the cases were diagnosed as struma ovarii preoperatively. Of the seven patients who had confirmed a desire for future childbearing, four patients were suspected for borderline or malignant tumor preoperatively, and underwent abdominal adnexectomy. In patients without a desire for childbearing, laparoscopic surgery was performed in only 45% of the patients whose preoperative diagnosis was benign. On magnetic resonance imaging (MRI), 54% of the cases showed enhanced solid components, which is characteristic of malignant tumors, but diffusion restriction was observed in only 11%. On computed tomography (CT), 78% of the cases showed a high attenuation lesion reflecting thyroid tissue.ConclusionsStruma ovarii is difficult to distinguish from malignancy preoperatively, making the choice of surgical approach complicated. A comprehensive evaluation of diffusion‐weighted MRI and CT findings may improve the accuracy of preoperative diagnosis of struma ovarii.
Effect of acupressure applied to L4 point on the severity of fistula needle pain in patients: A randomised control trial
Authors: Çevik Banu , Turgay Gülay , Inanoğlu Işılay , Kaya Semiha , Sayin Cihat Burak 
Published: January 2023

AbstractBackgroundPatients usually feel pain when a needle is inserted into the fistula. This acute pain can be relieved by acupressure, which is a nonpharmacological application method.ObjectiveThis study was designed to explore the effect of acupressure application to the Hegu point on the severity of acute pain caused by fistula needle insertion in patients with antecubital arteriovenous fistula.DesignIt is a randomised control study.ParticipantsThe study was conducted with 32 intervention and 32 control patients, recruited from a dialysis centre of a foundation university in Turkey between October 2021 and January 2022.MeasurementsAcupressure was applied 3 min before needle placement in the fistula area of the patients in the experimental group.ResultWhile there was no decrease in the severity of acute pain during fistula needle insertion in the patients in the control group, there was a significant decrease in the mean acute pain severity scores experienced by the patients in the experimental group, whose Hegu point acupressure was applied.ConclusionThe results of this study support the effectiveness of Hegu point acupressure as an effective and low‐cost way to reduce the acute pain of needle insertion put on dialysis patients with a fistula. In addition, the results provide a practical reference for acute pain management for dialysis nurses.
Phylogenomic insights into the reticulate evolution of Camellia sect. Paracamellia Sealy (Theaceae)
Authors: Qin Sheng‐Yuan , Chen Kai , Zhang Wen‐Ju , Xiang Xiao‐Guo , Zuo Zheng‐Yu , Guo Cen , Zhao Yao , Li Lin‐Feng , Wang Yu‐Guo , Song Zhi‐Ping , Yang Ji , Yang Xiao‐Qiang , Zhang Jian , Jin Wei‐Tao , Wen Qiang , Zhao Song‐Zi , Chen Jia‐Kuan , Li De‐Zhu , Rong Jun 
Published: January 2023

AbstractPolyploids are common in Camellia sect. Paracamellia, which contain many important oil crop species. However, their complex evolutionary history is largely unclear. In this study, 22 transcriptomes and 19 plastomes of related species of Camellia were sequenced and assembled, providing the most completed taxa sampling of Camellia sect. Oleifera and C. sect. Paracamellia. Phylogenetic trees were reconstructed with predicted single‐copy nuclear genes and plastomes. Phylogenetic trees with nuclear genes demonstrated that C. sect. Oleifera should be merged into C. sect. Paracamellia. Cytonuclear discordance and network analyses suggested hybridizations among polyploid species and relatives. The divergence of major clades in C. sect. Paracamellia was dated to be during the middle to late Miocene from the ancestral Lingnan region, and a rapid diversification during the Quaternary was found, probably through hybridization and polyploidization. The tetraploid Camellia meiocarpa Hu may have originated from hybridization between closely related diploid species. The hexaploid Camellia oleifera C. Abel probably originated from hybridization between closely related diploid and tetraploid (e.g., C. meiocarpa) species. The octoploid Camellia vietnamensis T. C. Huang ex Hu could have originated from hybridization between hexaploid C. oleifera and the closely related diploid species. Hybridization and polyploidization played an important role in generating the rich variation of important fruit traits, especially increased fruit size in polyploid species.
Calcineurin B‐like interacting protein kinase 31 confers resistance to sheath blight via modulation of ROS homeostasis in rice
Authors: Chen Huan , Lin Qiujun , Li Zhuo , Chu Jin , Dong Hai , Mei Qiong , Xuan Yuanhu 
Published: January 2023

AbstractSheath blight (ShB) severely threatens rice cultivation and production; however, the molecular mechanism of rice defence against ShB remains unclear. Screening of transposon Ds insertion mutants identified that Calcineurin B‐like protein‐interacting protein kinase 31 (CIPK31) mutants were more susceptible to ShB, while CIPK31 overexpressors (OX) were less susceptible. Sequence analysis indicated two haplotypes of CIPK31: Hap_1, with significantly higher CIPK31 expression, was less sensitive to ShB than the Hap_2 lines. Further analyses showed that the NAF domain of CIPK31 interacted with the EF‐hand motif of respiratory burst oxidase homologue (RBOHA) to inhibit RBOHA‐induced H2O2 production, and RBOHA RNAi plants were more susceptible to ShB. These data suggested that the CIPK31‐mediated increase in resistance is not associated with RBOHA. Interestingly, the study also found that CIPK31 interacted with catalase C (CatC); cipk31 mutants accumulated less H2O2 while CIPK31 OX accumulated more H2O2 compared to the wild‐type control. Further analysis showed the interaction of the catalase domain of CatC with the NAF domain of CIPK31 by which CIPK31 inhibits CatC activity to accumulate more H2O2.
PhAAT1, encoding an anthocyanin acyltransferase, is transcriptionally regulated byPhAN2in petunia
Authors: Chen Zeyu , Yuan Junwei , Yao Yi , Cao Jiahao , Yang Wenjie , Long Yu , Liu Juanxu , Yang Weiyuan 
Published: January 2023

AbstractAnthocyanins widely exist in plants and they are important pigments for color of petals and fruits. They are produced through a multi‐step pathway controlled by transcription factor complexes. The anthocyanin skeleton modification is the last reaction in the anthocyanin synthesis pathway, which improves the stability of anthocyanins. Acylation modification is an important modification of anthocyanins. However, the identification and function of anthocyanin acyltransferase genes and their expression regulation are rarely reported. In this study, we identified the petunia anthocyanin acyltransferase gene,PhAAT1. PhAAT1 is located in the cytoplasm andPhAAT1silencing changed flower color and reduced the stability of anthocyanin. Metabolomics analysis showed thatPhAAT1silencing led to the reduction of p‐coumaroylated and caffeoylated anthocyanins. In addition,PhAAT1was positively regulated by the MYB transcription factor, PhAN2, which directly interacts with the promoter ofPhAAT1.
Agricultural wastes for brine shrimp Artemia production: A review
Authors: Ogburn Nepheronia Jumalon , Duan Luchun , Subashchandrabose Suresh Ramraj , Sorgeloos Patrick , O'Connor Wayne , Megharaj Mallavarapu , Naidu Ravi 
Published: January 2023

AbstractAn increasing global population has meant aquaculture, one of the fastest growing food industry sectors, faces significant sustainability challenges as it tries to address the rising global protein demand. In many sectors, production is underpinned by fishmeal as dietary ingredient, but this is a finite resource with competing users from the poultry and livestock industries. Alternatively, some (planktonic) aquatic species, especially brine shrimp Artemia, can be produced using agricultural waste to provide food or biomass to support increasing aquaculture demand. This review investigates research and production of Artemia using agricultural waste. Various systems used for Artemia production in inoculated ponds are analysed and discussed to provide options for environmentally sustainable food systems that can be applied from either an artisanal level in developing countries with a considerable labour force, or in intensive systems in countries with large volumes of under‐utilised resources, for example, sugar/alcohol‐based waste and inland saline areas. Using agricultural waste, single cell protein production in a separate aerobic digester can be a simple, continuous food source for Artemia to enable daily biomass harvest. This could then be used as a fishmeal replacement or possibly for human consumption to promote a circular economy by remediating waste to produce protein, like a food production mine.
Cell‐free next‐generation sequencing impacts diagnosis and antimicrobial therapy in immunocompromised hosts: A retrospective study
Authors: Vissichelli Nicole C. , Morales Megan K. , Kolipakkam Bharadhwaj , Bryson Alexandra , Sabo Roy T. , Toor Amir A. 
Published: January 2023

AbstractBackgroundCell‐free next‐generation sequencing (cfNGS) may have a unique role in the diagnosis of infectious complications in immunocompromised hosts. The rapid turnaround time and non‐invasive nature make it a promising supplement to standard of care.MethodsThis retrospective, observational single‐center study at a tertiary care medical center in Virginia investigated the use of cfNGS in clinical practice. Patients over age 18 years with cfNGS performed for any indication were included. The primary outcome was detection of bacteria and/or fungi on cfNGS. The secondary outcomes were concordance, and abundance of fungal and bacterial organism concentration detected over time from symptom onset, and clinical impact.ResultsThirty‐six patients (92% immunosuppressed) were identified and included. Twenty‐one (58%) tests detected one to five organisms (14/21 bacteria, 8/21 fungi, and 6/21 viruses). The clinical impact of cfNGS was positive in 52.8% of cases, negative in 2.8%, and negligible in 44.4%. Positive tests prompted therapy changes in 12 of 21 patients; six of 20 bacteria and seven of eight fungi identified were considered clinically pathogenic. Three bacteria identifications and six fungi identifications prompted targeted treatment. When fungal species were not identified by cNFGS, antifungal de‐escalation occurred in seven patients.ConclusioncfNGS assisted in critical management changes, including initiation of treatment for identified organisms and antimicrobial de‐escalation. Its non‐invasive nature and rapid turnaround time make this an important adjunct to standard of care testing that may assist in providing earlier, targeted therapy, especially when opportunistic pathogens remain high on the differential diagnosis.
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Association of patient characteristics with the receipt of regional anesthesia
Authors: Beletsky Alexander , Currie Morgan , Shen Jonathan , Maan Ramneek , Desilva Mahesh , Winston Nutan , Gabriel Rodney A 
Published: January 2023

BackgroundRegional anesthesia (RA) may improve patient-related outcomes, including decreased operative complications, shortened recovery times, and lower hospital readmission rates. More analyses are needed using a diverse set of databases to examine characteristics associated with the receipt of RA.MethodsA national hospital database was queried for patients 18 years or older who underwent total shoulder arthroplasty (TSA), total knee arthroplasty (TKA), anterior cruciate ligament reconstruction (ACLR), carpal tunnel release, ankle open reduction, and internal fixation and arteriovenous fistula creation between January 2016 and June 2021. Regional techniques included neuraxial anesthesia and various upper and lower extremity peripheral nerve blocks to create a binary variable of RA receipt. Univariate statistics were used to compare characteristics associated based on RA receipt and multivariable regression identified factors associated with RA receipt.ResultsA total of 51 776 patients were included in the analysis, of which 2111 (4.1%) received RA. Factors associated with decreased odds of RA receipt included black race (vs white race; OR 0.73, 95% CI 0.62 to 0.86), other non-white race (vs white race; OR 0.71, 95% CI 0.61 to 0.86), American Society of Anesthesiologists (ASA) class (vs ASA 1; OR 0.85, 95% CI 0.79 to 0.93), and Medicaid insurance (vs private insurance; OR 0.65, 95% CI 0.51 to 0.82) (all p<0.05). When compared with TKA, ACLR (OR 0.67, 95% CI 0.53 to 0.84), ankle open reduction and internal fixation (OR 0.68, 95% CI 0.58 to 0.81), and carpal tunnel release (OR 0.68, 95% CI 0.59 to 0.78) demonstrated lower odds of RA receipt, whereas TSA (OR 1.31, 95% CI 1.08 to 1.58) demonstrated higher odds of RA receipt (all p<0.05).ConclusionRA use varies with respect to race, insurance status, and type of surgery.
Breaking Bad: Quantifying the Addiction of Web Elements to JavaScript
Authors: Fouquet Romain , Laperdrix Pierre , Rouvoy Romain 
Published: January 2023

While JavaScript established itself as a cornerstone of the modern web, it also constitutes a major tracking and security vector, thus raising critical privacy and security concerns. In this context, some browser extensions propose to systematically block scripts reported by crowdsourced trackers lists. However, this solution heavily depends on the quality of these built-in lists, which may be deprecated or incomplete, thus exposing the visitor to unknown trackers. In this article, we explore a different strategy by investigating the benefits of disabling JavaScript in the browser. More specifically, by adopting such a strict policy, we aim to quantify the JavaScript addiction of web elements composing a web page through the observation of web breakages. As there is no standard mechanism for detecting such breakages, we introduce a framework to inspect several page features when blocking JavaScript, that we deploy to analyze 6,384 pages, including landing and internal web pages. We discover that 43% of web pages are not strictly dependent on JavaScript and that more than 67% of pages are likely to be usable as long as the visitor only requires the content from the main section of the page, for which the user most likely reached the page, while reducing the number of tracking requests by 85% on average. Finally, we discuss the viability of currently browsing the web without JavaScript and detail multiple incentives for websites to be kept usable without JavaScript.