bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effectiveness of golimumab intensification in ulcerative colitis: A multicentric prospective study
Authors: Fumery Mathurin , Nancey Stéphane , Filippi Jérôme , Altwegg Romain , Hébuterne Xavier , Boshetti Gilles , Barraud Mathilde , Meynier Jonathan , Paul Stéphane , Roblin Xavier 
Published: February 2023

SummaryIntroductionLoss of response to golimumab occurs in nearly 40% of patients with ulcerative colitis (UC). Unlike others anti‐TNF, no study has reported a correlation between serum golimumab level and response to drug intensification. The objective of this study was to evaluate the effectiveness and safety of golimumab intensification and to identify the best threshold of serum golimumab before drug intensification predictive of response.Patients and MethodsWe included all consecutive patients with active UC with loss of response to golimumab in a prospective multicentric cohort study. Patients with loss of response at 50 mg q4 weeks (W) and 100 mg q4W underwent therapeutic intensification at 100 mg q4W and 100 mg q2W, respectively. Effectiveness and safety were assessed between Weeks 2 and 4 (visit 2) and between Weeks 4 and 8 (visit 3) after intensification. Serum level and anti‐golimumab antibodies were evaluated at each medical visit (Lisa Tracker, Theradiag France).ResultsA total of 47 UC patients (Female, 50%; median age, 39 years (IQR, 27–52)) treated with golimumab for a median of 20.4 weeks (IQR, 10.7–38.3) were included. The median partial Mayo score was 6 (IQR, 5–7), and the median endoscopic Mayo score was 3 (IQR, 2–3). The median golimumab serum level before intensification was 2.23 μg/mL (IQR, 1.02–3.96) and only one patient (2.1%) had anti‐drug antibodies. At Visit 2 (Week 2–4), 40% patients experienced clinical response, 10% clinical remission, 33% endoscopic response and 23% endoscopic remission. At Visit 3 (Week 4–8), 44% of patients had clinical response, 22% of patients had clinical remission, 45% of patients had endoscopic response, and 41% of patients had endoscopic remission. The median golimumab levels before intensification do not differ between responders and non‐responders (2.13 μg/ml (0.76–2.76) and 3.37 μg/ml (IQR, 1.08–4.67), respectively; p = 0.14) assessed at Visit 3. Golimumab intensification to 100 mg q4W (vs q2W) (OR 1.98, 95% CI [1.06–3.70]; p = 0.032) was significantly associated with clinical remission at Visit 3. Serum drug level at baseline or the presence of antidrug antibodies were not associated with clinical or endoscopic remission/response. Two serious adverse events (one infection and one UC flare) were reported during the 24‐week follow‐up.ConclusionIn this prospective multicentric study, half of patients recaptured response following golimumab intensification in UC. Therapeutic drug monitoring did not predict response after optimisation of golimumab.
Present and prospective health status of older adults in the Philippines: The role of education
Authors: Vicerra Paolo Miguel Manalang 
Published: February 2023

AbstractUtilizing current information to project prospective ill health prevalence can help prepare the country to ensure the well‐being of older people. The prevalence of ill health in terms of physical, psychological, and cognitive health dimensions was estimated by age, sex, and education attainment level using the 2018 Longitudinal Study on Aging and Health in the Philippines. Subsequently, the said rates were integrated into population projection estimates from 2020 to 2080. It was observed that the depression prevalence rate among older people was highest at above 40%, while physical and cognitive limitations were at around 18% and 22% respectively. It was also found that prevalence rates of ill health increased with age and that ill health was more prevalent among women than men, particularly at more advanced ages. The use of population projections has shown that education differentials in the analyses estimate lower prevalence rates of ill health for both sexes. The findings provide estimates for the prospective care needs of the older population in the Philippines. It was also suggested that education may possibly have preventive effects on ill health. Utilizing present information in order to prepare for issues can be beneficial for securing the well‐being of older adults.
Documentary analysis of the legal and policy framework of transracial adoption in South Africa
Authors: Luyt Jean , Swartz Leslie 
Published: February 2023

AbstractTransracial adoption was legalized in South Africa through legislative reform as South Africa moved into a post‐apartheid era of non‐racialism. Transracial adoption offers one option of placement for Black children in need of alternative care. However, adoption continues to face obstacles to implementation, including cultural obstacles which impact on placement of Black African children. This paper reports on adoption statistics on national adoption in the period 2013–2021 and a documentary analysis of the current legal and policy framework governing transracial adoption. We cover international instruments, local laws, including the Children's Act of 2005, and relevant policy documents designed to facilitate the implementation of adoption. We show that the law is supportive of transracial adoption, but that policy documents offer a somewhat contradictory stance to the practice. The lack of success of transracial adoption as a child protection strategy does not lie within the legal framework but may lie in the difficulties in interpreting and implementing the range of different policies by those implementing these policies. More research into the implementation practice of these bureaucrats is required to understand the underutilization of transracial adoption as a placement option for Black children in South Africa.
Texture Inpainting for Photogrammetric Models
Authors: Maggiordomo A. , Cignoni P. , Tarini M. 
Published: February 2023

AbstractWe devise a technique designed to remove the texturing artefacts that are typical of 3D models representing real‐world objects, acquired by photogrammetric techniques. Our technique leverages the recent advancements in inpainting of natural colour images, adapting them to the specific context. A neural network, modified and trained for our purposes, replaces the texture areas containing the defects, substituting them with new plausible patches of texels, reconstructed from the surrounding surface texture. We train and apply the network model on locally reparametrized texture patches, so to provide an input that simplifies the learning process, because it avoids any texture seams, unused texture areas, background, depth jumps and so on. We automatically extract appropriate training data from real‐world datasets. We show two applications of the resulting method: one, as a fully automatic tool, addressing all problems that can be detected by analysing the UV‐map of the input model; and another, as an interactive semi‐automatic tool, presented to the user as a 3D ‘fixing’ brush that has the effect of removing artefacts from any zone the users paints on. We demonstrate our method on a variety of real‐world inputs and provide a reference usable implementation.
Effect of small vessel disease severity on blood pressure management after endovascular therapy in theBP TARGETtrial
Authors: Brauner Ran , Gory Benjamin , Lapergue Bertrand , Sibon Igor , Richard Sebastien , Kyheng Maeva , Labreuche Julien , Desilles Jean‐Philippe , Blanc Raphael , Piotin Michel , Halimi Jean‐Michel , Mazighi Mikael , Maïer Benjamin ,   for the BP TARGET Investigators
Published: February 2023

AbstractBackground and purposeAcute ischaemic stroke patients with cerebral small vessel disease (CSVD), including cerebral microbleeds (CMBs) and white matter hyperintensities (WMHs), have worse outcomes. The effect was investigated of two blood pressure strategies (intensive vs. standard) and blood pressure variability (BPV) after reperfusion according to CSVD burden in the BP TARGET trial.MethodsPatients with available magnetic resonance imaging at baseline were included. CMBs were described as absent or present and WMH severity was described according to the Fazekas classification (0–1, absent–mild; 2–3, moderate to severe). Outcomes consisted of any intracerebral hemorrhage (ICH) at 24 h and favorable outcome at 90 days (modified Rankin Scale score between 0 and 2).ResultsIn all, 246 patients were included. The intensive systolic blood pressure target was not associated with lower rates of ICH or favorable outcome according to CSVD subgroups (allpvalues >0.35). Several BPV parameters were associated with increased odds of ICH in patients with CMBs but not in patients without CMBs (diastolic blood pressure coefficient of variation, odds ratio 2.06, 95% confidence interval [CI] 1.13–3.77, in patients with ≥1 CMB vs. 0.94, 95% CI 0.68–1.31, in patients without CMBs,phet = 0.026). Several diastolic BPV parameters were associated with worse outcomes in patients with severe WMHs but not in patients without WMHs (diastolic blood pressure coefficient of variation, odds ratio 0.32, 95% CI 0.17–0.61, in patients with severe WMHs vs. 1.09, 95% CI 0.67–1.79, in patients without WMHs;phet = 0.003).ConclusionNo effect of the intensive systolic blood pressure management strategy was found on ICH occurrence or functional outcome according to CSVD burden. BPV was associated with higher odds of ICH in patients with CMBs and worse outcome in patients with moderate‐to‐severe WMHs.
The flaneur in the Borsig locomotive works: Walter Benjamin, the Berlin Radio Youth Hour, and sound as pedagogy
Authors: Amidon Kevin S. 
Published: February 2023

AbstractWalter Benjamin's radio addresses for young people remain a comparatively neglected part of his work. New scholarship and translations have begun to address this, however. This article argues that the radio addresses, and particularly the address on the Borsig locomotive and machine works, deserve a prominent place within the critical and intellectual trajectory of Benjamin's career. A close reading of “Borsig” demonstrates how the addresses model the modes of experience mediated by and through Benjamin's master figure of the flaneur and generate the possibility for a historical pedagogy adequate to modernity. In the radio addresses, in general, and in “Borsig,” in particular, the mediation of experience entirely through sound and the narrating voice requires the simultaneity of past, present, and future that resolves into Benjamin's theory of history. “Borsig” thus points directly toward the stakes of the Passagen‐Werk and Benjamin's later theoretical essays.
Different prognostic role of EGFR mutation according to the IASLC histological grade in patients with resected early‐stage lung adenocarcinoma
Authors: Hong Tae H , Hwang Soohyun , Choi Yoon‐La , Lee Genehee , Park Sehhoon , Ahn Myung‐Ju , Lee Yoonseo , Jeon Yeong J , Lee Junghee , Shin Sumin , Park Seong Y , Cho Jong H , Choi Yong S , Kim Jhingook , Shim Young M , Cho Juhee , Kim Hong K 
Published: February 2023

AimsThe prognostic role of EGFR mutations remains controversial. We aimed to evaluate the prognostic role of EGFR mutation in consideration of the IASLC histological grade in patients with resected early‐stage lung adenocarcinoma.Methods and resultsA total of 3297 patients with stages I–IIA resected lung adenocarcinoma who had had EGFR mutation tests between January 2014 and December 2019 at the Samsung Medical Center, Seoul, Korea were included. Recurrence‐free survival (RFS) was compared by EGFR mutation status (EGFR‐M+ versus EGFR‐WT) and IASLC histological grade (G1, G2 and G3). Cox proportional hazards models were used to estimate the adjusted HRs (aHRs) and 95% confidence intervals (CIs).ResultsCompared to the EGFR‐WT group, the EGFR‐M+ group had a significantly lower proportion of G3 tumour (16 versus 33%, P < 0.001). During a median follow‐up of 41.4 months, 376 patients experienced recurrence. After adjusting for histological grade, the aHR for recurrence comparing the EGFR‐M+ to the EGFR‐WT was 1.30 (95% CI = 1.04–1.62, P = 0.022). The EGFR‐M+ group had a significantly lower 5‐year RFS than the EGFR‐WT group among G3 patients (58.4 versus 71.5%, P < 0.001), but not among G1 and G2 patients.ConclusionsEGFR mutation status was associated with a risk of recurrence after consideration of the IASLC histological grading, especially in G3 tumours. The results of this study would be useful for developing a new staging system and identifying a subset of patients who may benefit from adjuvant targeted therapy.
Lack of reproducibility of histopathological features in MYC‐rearranged large B cell lymphoma using digital whole slide images: a study from the Lunenburg lymphoma biomarker consortium
Authors: Natkunam Yasodha , de Jong Daphne , Farinha Pedro , Gaulard Philippe , Klapper Wolfram , Rosenwald Andreas , Sander Birgitta , Tooze Reuben , Advani Ranjana , Burton Catherine , Gribben John G , Kersten Marie‐José , Kimby Eva , Lenz Georg , Molina Thierry , Morschhauser Franck , Scott David , Sehn Laurie , Stevens Wendy , Clear Andrew , Baia Maryse , Habi Abdelmalek , Elsensohn Mad‐Helenie , Langlois‐Jacques Carole , Maucort‐Boulch Delphine , Calaminici Maria 
Published: February 2023

AimsSubclassification of large B cell lymphoma (LBCL) is challenging due to the overlap in histopathological, immunophenotypical and genetic data. In particular, the criteria to separate diffuse large B cell lymphoma (DLBCL) and high‐grade B cell lymphoma (HGBL) are difficult to apply in practice. The Lunenburg Lymphoma Biomarker Consortium previously reported a cohort of over 5000 LBCL that included fluorescence in‐situ hybridisation (FISH) data. This cohort contained 209 cases with MYC rearrangement that were available for a validation study by a panel of eight expert haematopathologists of how various histopathological features are used.Methods and resultsDigital whole slide images of haematoxylin and eosin‐stained sections allowed the pathologists to visually score cases independently as well as participate in virtual joint review conferences. Standardised consensus guidelines were formulated for scoring histopathological features and included overall architecture/growth pattern, presence or absence of a starry‐sky pattern, cell size, nuclear pleomorphism, nucleolar prominence and a range of cytological characteristics. Despite the use of consensus guidelines, the results show a high degree of discordance among the eight expert pathologists. Approximately 50% of the cases lacked a majority score, and this discordance spanned all six histopathological features. Moreover, none of the histological variables aided in prediction of MYC single versus double/triple‐hit or immunoglobulin‐partner FISH‐based designations or clinical outcome measures.ConclusionsOur findings indicate that there are no specific conventional morphological parameters that help to subclassify MYC‐rearranged LBCL or select cases for FISH analysis, and that incorporation of FISH data is essential for accurate classification and prognostication.
Range expansions of sexual versus asexual organisms: Effects of reproductive assurance and migration load
Authors: Satow Takeaki , Takimoto Gaku 
Published: February 2023

AbstractIt is generally considered that sexual organisms show faster evolutionary adaptation than asexual organisms because sexuals can accumulate adaptive mutations through recombination. Yet, empirical evidence often shows that the geographic range size of sexual species is narrower than that of closely related asexual species, which may seem as if asexuals can adapt to more varied environments. Two potential explanations for this apparent contradiction considered by the existing theory are reproduction assurance and migration load. Here, we consider both reproductive assurance and migration load within a single model to comparatively examine their effects on range expansions of sexuals and asexuals across an environmental gradient. The model shows that higher dispersal propensity decreases sexuals' disadvantage in reproductive assurance while increasing their disadvantage in migration load. Moreover, lower mutation rate constrains adaptation more strongly in asexuals than in sexuals. Thus, high dispersal propensity and high mutation rates promote that asexuals have wider range sizes than sexuals. Intriguingly, our model reveals that sexuals can have wider geographic range sizes than asexuals under low dispersal propensity and low mutation rates, a pattern consistent with a few exceptional empirical cases. Combining reproductive assurance and migration load provides a useful perspective to better understand the relationships between species' mating systems and their geographic ranges.
Semblances of truth: The Romantic lyric revisited
Authors: Townsend Chris 
Published: February 2023

AbstractThe ‘Romantic lyric’ as an idea or critical entity finds itself doubly maligned in contemporary lyric studies. As a perceived product of New Criticism, it finds itself accused by historicists of bringing about the ‘lyricisation’ of poetry in twentieth‐century criticism, and, as a mimetic model of subjective expression, it’s disfavoured by lyric theorists who view it as a stepping stone towards the currently common misconception that lyrics are a species of dramatic monologue. Yet returning to the Romantics themselves, we discover other models of the lyric that sit outside the expressive model or the paradigm of lyricisation, and which may well be of use to contemporary lyric studies. This essay offers a reading of one such model in the works of Samuel Taylor Coleridge, in the form of lyric’s semblance character: Coleridge is peculiarly and persistently concerned with the way the world appears to be (which is often not how the world really is), and his lyric poetry figures as a kind of seemingness in its own right, and one that reflects on the nature of appearances themselves. Before making a case for lyric semblance, this essay offers an overview of the state of lyric studies today, taking as exemplary the work of Virginia Jackson and Jonathan Culler; it places emphasis on the role of the ‘Romantic lyric’ in both accounts, and teases out some of what’s at stake in the tension between historicism and formalism that is at the centre of lyric studies today.
The state, identity politics and ethnic boundaries in Afghanistan: The case of Sunni Hazaras
Authors: Ibrahimi Niamatullah 
Published: February 2023

AbstractIn recent years, a growing number of activists in Afghanistan have been proactively self‐identifying as Sunni Hazaras. The trend demonstrates an important shift that illuminates how ethnic boundaries may change and evolve in response to elite politics and state policies in Afghanistan. Many of the communities that are the subjects of new collective identity discourses share important commonalities, including shared belief in a common origin, with the Shi'a Hazaras. However, because the Shi'a Hazaras were persecuted and marginalised under successive regimes in Afghanistan, it was not common for these communities to publicly identify as Hazaras. Instead, they tended to identify with local identity categories such as those based on places of origin or as Tajiks because, like most Tajiks, they speak Dari and practise Sunni Islam. This article contributes to understanding these dynamics through a detailed examination of the National Council of the Sunni Hazaras of Afghanistan. Taking a social constructivist approach, it develops an argument that emphasises an interactive process between state formation and top‐down programmes of national identity construction and bottom‐up resistance by groups that appropriate and articulate ethnic and other forms of ethnic identities to demand political representation and symbolic recognition.
Metallochaperone OsHIPP9 is involved in the retention of cadmium and copper in rice
Authors: Xiong Shuo , Kong Xiaohang , Chen Guoqiang , Tian Lihong , Qian Dandan , Zhu Zhen , Qu Le Qing 
Published: February 2023

AbstractMetallochaperones are a unique class of proteins that play crucial roles in metal homoeostasis and detoxification. However, few metallochaperones have been functionally characterised in rice. Heterologous expression of Heavy metal‐associated Isoprenylated Plant Protein 9 (OsHIPP9), a metallochaperone, altered yeast tolerance to cadmium (Cd) and copper (Cu). We investigated the physiological role of OsHIPP9 in rice. OsHIPP9 was primarily expressed in the root exodermis and xylem region of enlarged vascular bundles (EVB) at nodes. KO of OsHIPP9 increased the Cd concentrations of the upper nodes and panicle, but decreased Cd in expanded leaves. KO of OsHIPP9 decreased Cu uptake and accumulation in rice. Constitutive OX of OsHIPP9 increased Cd and Cu accumulation in aboveground tissues and brown rice. OsHIPP9 showed binding capacity for Cd and Cu. We propose that OsHIPP9 has dual metallochaperone roles, chelating Cd in the xylem region of EVB for Cd retention in the nodes and chelating Cu in rice roots to aid Cu uptake.
Evaluation of an immunochromatographic serologic test to detect the presence of anti‐Toxoplasma gondii antibodies in cats
Authors: Villanueva‐Saz Sergio , Martínez Mariví , Giner Jacobo , Pérez María Dolores , Tobajas Ana Pilar , Yzuel Andrés , Verde María Teresa , Lacasta Delia , Fernández Antonio , Marteles Diana , Ruíz Héctor 
Published: February 2023

AbstractBackgroundToxoplasmosis is a protozoan disease caused by Toxoplasma gondii. Different T. gondii confirmatory techniques, including serologic methods, are available to detect the presence of the parasite. Among serology techniques, immunochromatographic rapid testing could be a reliable alternative to serologic laboratory techniques.ObjectiveThis study evaluated a commercial immunochromatographic test (FASTest TOXOPLASMA g) in seronegative and seropositive cats.MethodsTwo indirect immunofluorescence antibody reference tests, an in‐house technique, and a commercial test were used to classify 292 feline serum samples. The rapid test was evaluated in different groups of cats, including healthy seronegative cats (n = 121), seropositive cats with variable anti‐Toxoplasma antibodies (n = 146), and cats with positive serologic results for other pathogens (n = 25). The sensitivity, specificity, accuracy, receiver operating characteristic curves, and kappa statistics were analyzed as performance measures.ResultsOf the 292 samples, 146 were classified as T. gondii seropositive and 146 as T. gondii seronegative. Concordant results were obtained for all samples using immunofluorescence antibody tests. The diagnostic measures of this rapid test showed 98.63% sensitivity and 100% specificity, and 99.32% accuracy. The kappa statistics value was 0.986, and the area under the receiver operating characteristic curve was 0.993.ConclusionsThis rapid test showed diagnostic measurements similar to those of traditional quantitative serologic methods. In situations where laboratory techniques are not available, this test, under clinical conditions, could be a useful alternative to obtain accurate results rapidly.