bluuebunny/crossref_metadata_2025_split huggingface dataset:
Experiences and Perceptions of School-Based Speech-Language Pathologists Related to Literacy: Results From a National Survey
Authors: Bridges Mindy Sittner , Kelley Elizabeth 
Published: January 2023

Purpose:
School-based speech-language pathologists (SLPs) play an important role in supporting children with reading and writing difficulties. The purpose of this study was to describe the training, experiences, and knowledge of SLPs who work in preschool, elementary school, or middle/high school settings in relation to children with reading and writing difficulties.

Method:

Preschool and school-based SLPs (
N
= 280) participated in an online survey, with items related to preservice and in-service training experiences, experiences and perceptions of competence related to reading and writing assessment and instruction with students on their caseload, and knowledge of reading and writing.

Results:
The majority of respondents reported limited preservice coursework and clinical training experiences with students with reading and writing difficulties. Many SLPs reported that more than half of the students on their caseload had reading and writing difficulties, but many SLPs (approximately 40%) had poor confidence in their abilities in assessment and intervention with children with reading and writing difficulties.

Conclusions:
Nearly all SLPs indicated that they would benefit from additional training and experience with children with reading and writing difficulties. We provide some initial suggestions for graduate coursework, clinical training experiences, and tailored professional development.

Supplemental Material:

https://doi.org/10.23641/asha.21809514
Ableism to Empowerment: Navigating School Structures When Working With Students Who Stutter
Authors: Reeves Nina A. , Flynn Timothy W. , Schuff Reuben Z. 
Published: January 2023

Purpose:
School-based speech-language pathologists (SLPs) face uniquely complex webs of guidelines and criteria that can undermine their ability to move toward disability-affirming practices. The purpose of this clinical focus article is to present a contrast between ableist and disability-affirming practices in school-based stuttering therapy while highlighting the critical perspectives of students who stutter. Practical examples of disability-affirming stuttering therapy in public school settings are provided.

Conclusions:
This clinical focus article outlines practical guidelines and specific examples of affirming collaboration, eligibility decisions, goal choice, and accommodations for students who stutter. These discussions demonstrate how SLPs can adopt updated assessment therapy planning and institutional practices to affirm students who stutter while informing school cultures and society about the dignity and value of stuttered voices.

Supplemental Material:

https://doi.org/10.23641/asha.21818028
Reflections on nebulae around young stars
Authors: Gupta A. , Miotello A. , Manara C. F. , Williams J. P. , Facchini S. , Beccari G. , Birnstiel T. , Ginski C. , Hacar A. , Küffmeier M. , Testi L. , Tychoniec L. , Yen H.-W. 
Published: January 2023

Context. While it is generally assumed that Class II sources evolve largely in isolation from their environment, many still lie close to molecular clouds and may continue to interact with them. This may result in late accretion of material onto the disk that can significantly influence disk processes and planet formation.
Aims. In order to systematically study late infall of gas onto disks, we identify candidate Class II sources in close vicinity to a reflection nebula (RN) that may be undergoing this process.
Methods. First we targeted Class II sources with known kilo-au scale gas structures – possibly due to late infall of material – and we searched for RNe in their vicinity in optical and near-infrared images. Second, we compiled a catalogue of Class II sources associated with RNe and looked for the large-scale CO structures in archival ALMA data. Using the catalogues of protostars and RNe, we also estimated the probability of Class II sources interacting with surrounding material.
Results. All of the sources with large-scale gas structures also exhibit some reflection nebulosity in their vicinity. Similarly, at least five Class II objects associated with a prominent RNe, and for which adequate ALMA observations are available, were found to have spirals or stream-like structures which may be due to late infall. We report the first detection of these structures around S CrA.
Conclusions. Our results suggest that a non-negligible fraction of Class II disks in nearby star-forming regions may be associated with RNe and could therefore be undergoing late accretion of gas. Surveys of RNe and kilo-au scale gas structures around Class II sources will allow us to better understand the frequency and impact of late-infall phenomena.
Das Potenzial komplementärer Musikinterventionen bei Patienten mit malignen Kopf-Hals-Tumoren
Authors: Haeussler Daniel , Mayer Christopher , Schell Angela , Zaubitzer Lena , Büttner Sylvia , Gencer Deniz , Rotter Nicole , Kramer Benedikt 
Published: January 2023

Zusammenfassung
Zweck Etablierte Behandlungsschemata für Patienten mit malignen Kopf-Hals-Tumoren führen häufig zu körperlichen und psychischen Gesundheitsproblemen und können daher die Lebensqualität (QoL) dieser Patienten erheblich einschränken. Die in der Literatur verfügbaren Daten weisen darauf hin, dass ergänzende Behandlungen wie Musikinterventionen die Lebensqualität und Compliance der Patienten verbessern und die Symptome während der Therapie reduzieren können.
Methoden Im Rahmen einer ambulanten Vorstellung erfolgte eine anonyme Datenerhebung bei Patienten mit Kopf-Hals-Tumoren mittels eines selbst konzipierten Fragebogens. Dabei wurden die Patienten insbesondere nach ihrem Bedarf und Interesse an Musikinterventionen während der Tumortherapie befragt.
Ergebnisse Insgesamt wurden 138 Patienten in die Studie eingeschlossen, davon 68,1% Männer und 31,9% Frauen. Das Durchschnittsalter betrug 64,9 Jahre. Nur 11,5% hörten zum Zeitpunkt der Datenerhebung regelmäßig Musik während ihrer Therapie, jedoch gaben 52,2% der Patienten an, an Musikinterventionen interessiert zu sein. Die Patienten erhofften sich besonders entspannende und ermutigende Wirkungen durch das Musikhören. Die meisten würden dabei Gruppentherapien (56%) oder das Hören ihrer eigenen Musik (36,6%) bevorzugen.
Zusammenfassung Unsere Daten deuten auf ein hohes Potenzial von Musikinterventionen bei Patienten mit Kopf-Hals-Malignomen hin. Dabei scheinen positive Auswirkungen, einschließlich einer Verringerung somatischer und nichtsomatischer Symptome und einer verbesserten Lebensqualität, möglich. Der Mangel an einer homogenen Datenlage unterstreicht die Notwendigkeit weiterer Studien im Bereich der komplementären Musikinterventionen, um zukünftig wissenschaftsbasierte Konzepte in Krebsbehandlungszentren zu etablieren.
Understanding Preterm Birth in Pregnancies Complicated by Nonimmune Hydrops Fetalis
Authors: Swanson Kate , Norton Mary E. , Downum Sarah L. , Gonzalez-Velez Juan M. , Sparks Teresa N. 
Published: January 2023

Objective Nonimmune hydrops fetalis (NIHF) is associated with poor perinatal outcomes including preterm birth (PTB). However, the frequency and causes of PTB in this population are not well understood. We hypothesized that NIHF frequently results in PTB due to medically indicated delivery for fetal distress.
Study Design This was a secondary analysis of a prospectively enrolled cohort of pregnancies with NIHF that underwent exome sequencing if standard testing was nondiagnostic. The primary outcome was frequency of PTB at <37 weeks' gestation. Secondary outcomes were reasons for PTB, fetal predictors of PTB, and frequency of neonatal death following PTB.
Results Fifty-six cases were included, with a median gestational age at delivery of 32.8 weeks (interquartile range [IQR]: 30.3–35.0). Overall, 86% (48/56) were delivered preterm. Among 48 PTBs, 18 (38%) were spontaneous, 9 (19%) were medically indicated for maternal indications (primarily preeclampsia), and 21 (44%) were medically indicated for fetal indications (nonreassuring antenatal testing or worsening effusions). Neither fetal genetic diagnosis nor polyhydramnios was associated with PTB.
Conclusion More than four-fifths of pregnancies with NIHF result in PTB, often due to nonreassuring fetal status. These data are informative for counseling patients and for developing strategies to reduce PTB in pregnancies with NIHF.
Key Points
Coronavirus Disease 2019 Pandemic-Related Long-Term Chronic Impacts on Psychological Health of Perinatal Women in China
Authors: Zhang Enjie , Su Shaofei , Gao Shen , Liu Ruixia , Ding Xin , Zhang Yue , Xie Shuanghua , Liu Jianhui , Yue Wentao , Yin Chenghong 
Published: January 2023

Objectives The coronavirus disease 2019 (COVID-19) pandemic has caused far-reaching changes in all areas of society. However, limited data have focused on the long-term impacts on perinatal psychological health. This study aims to evaluate long-term impacts of COVID-19 pandemic crisis on psychological health among perinatal women and investigate associated factors.
Study Design A multicenter, cross-sectional study, the psychological subproject of China Birth Cohort Study (CBCS), was conducted in 2021. Demographic and obstetric characteristics, pregnancy outcomes, psychological status, and COVID-19-pandemic-related factors were obtained. The symptoms of depression, anxiety, and insomnia of participants were assessed by Patient Health Questionnaire, Edinburgh Postpartum Depression Scale, Generalized Anxiety Disorder Scale, and Insomnia Severity Index, respectively. Multivariate logistic regression was used to identify associated factors of adverse psychological symptoms.
Results Totally, 1,246 perinatal women were enrolled, with the overall prevalence of depression, anxiety, and insomnia symptoms being 63.16, 41.89, and 44.38%, respectively. Perinatal women who needed psychological counseling and were very worried about the COVID-19 pandemic were 1.8 to 7.2 times more likely to report symptoms of depression, anxiety, and insomnia. Unemployment, flu-like symptoms, younger maternal age, and previous diseases before pregnancy were risk factors for depression, anxiety, or insomnia.
Conclusion Our study revealed that the prevalence of perinatal depression, anxiety, and insomnia symptoms was at a high level even 1 year after the pandemic outbreak, implying pandemic-associated long-term psychological impacts on perinatal women existed. Government should not only pay attention to the acute effects of psychological health but also to long-term psychological impacts on perinatal women after major social events.
Key Points
Doppler Flow Indices and Prediction of Embryo Transfer Success and Pregnancy Outcome in Uterus Transplant Recipients
Authors: Johannesson Liza , Testa Giuliano , Borries Trevor M. , Wall Anji , Ma Tsung-wei , Eagle Elizabeth A. , Jain Akshaya , Taylor Sherri D. , dePrisco Gregory , Gregg Anthony R. 
Published: January 2023

Objective Doppler velocimetry of the uterine and umbilical arteries is used to predict preeclampsia and monitor fetal outcomes. There have been no reports of Doppler velocimetry indices in pregnancies conceived after uterus transplantation, which differ from traditional pregnancies because of different uterine vascular inflow and outflow and exposure to immunosuppressive agents. We sought to examine whether Doppler indices can be used to predict embryo transfer success after uterus transplantation and whether Doppler indices across pregnancy predict fetal growth restriction.
Study Design This was a single-center cohort observational study of 14 uterus transplant recipients who underwent embryo transfer. Of these, 12 women successfully delivered 14 babies. Five Doppler investigations were performed within the cohort: (1) prepregnancy; (2) uterine artery assessment across pregnancy; (3) umbilical artery assessment across pregnancy; (4) successive pregnancies; and (5) fetal growth.
Results Prepregnancy uterine artery Doppler indices did not correlate with successful implantation after embryo transfer. Uterine artery Doppler indices in uterus transplant recipients decreased across pregnancy as described in pregnancies without uterus transplantation. The umbilical artery systolic/diastolic velocity ratio was lower at all weeks of gestation after uterus transplantation compared with values described in pregnancies without uterus transplantation. In those women who delivered two successive babies after uterus transplant, umbilical artery Doppler indices were significantly lower during the second pregnancy. There was always forward flow throughout diastole in the umbilical arteries, and no babies experienced fetal growth restriction.
Conclusion In our study, uterus transplantation was not associated with abnormal blood flow indices in either the uterine or umbilical arteries. Although Doppler indices were not predictive of embryo transfer success, they supported the expectation that pregnancies after uterus transplantation at our center result in normally grown babies.
Key Points
Rate of Primary Cesarean Delivery by Language Preference among Nulliparas
Authors: Comfort Lizelle , Jain Meaghan , Wu Haotian , Nathan Lisa 
Published: January 2023

Objective Sociodemographic factors such as race/ethnicity and socioeconomic status affect primary cesarean delivery rates. Language is associated with disparate health care outcomes but has not been well studied in obstetrics. We examined the association between primary unscheduled cesarean delivery rate and preferred patient language.
Study Design A retrospective cohort study was conducted at an urban medical center between January 2017 and January 2020. Nulliparous women with early or full-term gestation and having no obstetric or medical contraindication to vaginal delivery were included. We used multivariable linear and logistic regressions to evaluate language differences in cesarean delivery odds and indication for cesarean.
Results Of the 1,314 eligible women, 76.8% of patients preferred English, 17.8% Spanish, and 5.4% other languages. Overall cesarean delivery rate was 27.6%. Controlling for age, race/ethnicity, body mass index, insurance, gravidity, pregnancy comorbidities, labor induction, and infant birth weight, Spanish- and other language-speaking women had significantly higher odds of undergoing cesarean compared with English-speaking women (adjusted odds ratio [OR]: 1.75; 95% confidence interval [CI]: 1.25, 2.46). Relative proportions of indications for cesarean did not differ by language group. Documented interpreter use was an effect modifier on the relationship between language preference and cesarean (OR with interpreter use: 2.89, 95% CI: 1.90, 4.39).
Conclusion Primary cesarean delivery rates were significantly higher among nulliparous women who prefer languages other than English. This difference may reflect lack of communication, provider bias or discrimination, or other factors, and should be further studied. Interpreter services should be routinely utilized and documented effectively.
Key Points
Adventures in 1,1-Diphenylacetone Dianion Chemistry
Authors: Langer Peter 
Published: January 2023

AbstractThe present personalized account highlights reactions of the dianion of 1,1-diphenylacetone and its applications. From a study directed towards the regioselectivity of such reactions a new allene synthesis via allene dianions was found by serendipity. In addition, reactions of allene dianions with various electrophiles have been studied.1	Introduction2	Cyclizations of the Dianion of 1,1-Diphenylacetone2.1	Reaction with Bis(cyclopentadienyl)zirconium Dichloride2.1	Reactions with Dichlorosilanes2.1	Reactions with Difluorosilanes2.1	Reactions with Ketones and Dielectrophiles3	Regioselectivity of Dianion Reactions4	Allene Dianions from Silyl Enol Ethers5	Scope of the Reactions of Allene Dianions6	Reactions of Allene Dianions with Ketones7	Reactions of Allene Dianions with Nitriles8	Conclusions
An Overview of Genes Involved in the Pure Joubert Syndrome and in Joubert Syndrome-Related Disorders (JSRD)
Authors: Amorini Maria , Iapadre Giulia , Mancuso Alessio , Ceravolo Ida , Farello Giovanni , Scardamaglia Annarita , Gramaglia Simone , Ceravolo Antonio , Salpietro Annamaria , Cuppari Caterina 
Published: January 2023

AbstractJoubert syndrome (JS) is a rare autosomal recessive disease characterized by a peculiar brain malformation, hypotonia, ataxia, developmental delay, abnormal eye movements, and neonatal breathing abnormalities. This picture is often associated with variable multiorgan involvement, mainly of the retina, kidneys and liver, defining a group of conditions termed syndrome and Joubert syndrome-related disorders (JSRD). Currently, more than 30 causative genes have been identified, involved in the development and stability of the primary cilium. Correlations genotype–phenotype are emerging between clinical presentations and mutations in JSRD genes, with implications in terms of molecular diagnosis, prenatal diagnosis, follow-up, and management of mutated patients.
Expression of microRNA Predicts Cardiovascular Events in Patients with Stable Coronary Artery Disease
Authors: Pedersen Oliver Buchhave , Grove Erik Lerkevang , Nissen Peter H. , Larsen Sanne Bøjet , Pasalic Leonardo , Kristensen Steen Dalby , Hvas Anne-Mette 
Published: January 2023

Background New biomarkers are warranted to identify patients with coronary artery disease (CAD) at high risk of recurrent cardiovascular events. It has been reported that the expression of microRNAs (miRs) may influence the development of CAD.
Objectives We aimed to investigate whether the expression of selected candidate miRs is a predictor of cardiovascular events in a cohort of stable CAD patients.
Methods We performed a single-center prospective study of 749 stable CAD patients with a median follow-up of 2.8 years. We investigated the expression of nine candidate miRs and their relation to cardiovascular events in this cohort. The primary endpoint was the composite of nonfatal myocardial infarction (MI), stent thrombosis (ST), ischemic stroke, and cardiovascular death. The composite of nonfatal MI and ST was analyzed as a secondary endpoint. Furthermore, nonfatal MI, ST, ischemic stroke, and all-cause mortality were analyzed as individual endpoints.
Results Employing receiver operating characteristic curves, it was shown that compared with traditional cardiovascular risk factors alone, combining the expression of miR-223–3p with existing traditional cardiovascular risk factors increased the predictive value of ST (area under the curve: 0.88 vs. 0.77, p = 0.04), the primary composite endpoint (0.65 vs. 0.61, p = 0.049), and the secondary endpoint of the composite of nonfatal MI and ST (0.68 vs. 0.62, p = 0.04).
Conclusion Among patients with CAD, adding miR-223–3p expression to traditional cardiovascular risk factors may improve prediction of cardiovascular events, particularly ST. Clinical trials confirming these findings are warranted.
Qualitative and Quantitative Evaluation of Morpho-Metabolic Changes in Bone Cartilage Complex of Knee Joint in Osteoarthritis Using Simultaneous 18F-NaF PET/MRI—A Pilot Study
Authors: Jena Amarnath , Goyal Nidhi , Rana Prerana , Taneja Sangeeta , Vaish Abhishek , Botchu Rajesh , Vaishya Raju 
Published: January 2023

Abstract
Background Articular cartilage (AC) loss and deterioration, as well as bone remodeling, are all symptoms of osteoarthritis (OA). As a result, an ideal imaging technique for researching OA is required, which must be sensitive to both soft tissue and bone health.
Objective The aim of this study was to assess the potential of simultaneous 18F sodium fluoride (18F-NaF) positron emission tomography/magnetic resonance imaging (PET/MRI) to identify as well as classify osseous metabolic abnormalities in knee OA and to see if degenerative changes in the cartilage and bone on MRI might be correlated with subchondral 18F-NaF uptake on PET.
Methods Sixteen (32 knees) volunteers with no past history of knee injury, with or without pain, were enrolled for the research from January to July 2021. The images of both knees were taken utilizing an molecular magnetic resonance (mMR) body matrix coil on a simultaneous PET/MRI biograph mMR. The acquisition was conducted after 45 minutes of intravenous infusion of 18F-NaF 185–370 MBq (5–10 mCi) over one PET bed for 40 minutes, while MRI sequences were performed simultaneously.
Results All pathologies showed significantly higher maximum standardized uptake value (SUVmax) than the background. Thirty-four subchondral magic spots were identified on 18F-NaF PET without any structural alteration on MRI. Bone marrow lesions (BMLs) and osteophytes with higher MRI osteoarthritis knee score (MOAKS) score showed higher 18F-NaF uptake (grade1˂grade2˂grade3). BMLs had corresponding AC degeneration. There was discordance between grade 1 osteophytes (86.6%), sclerosis (53.7%) and grade 1 BML in cruciate ligament insertion site (91.66%); they did not have high uptake of 18F-NaF. In case of cartilage, there was significant difference between AC grades and average subchondral SUVmax and T2* relaxometry (grade0˂grade1˂grade2˂grade3˂grade4). BMLs are much more metabolically active than other pathologies, while sclerosis is the least. We also found that the subchondral uptake was statistically increased in the areas of pathology:
Conclusion 18F-NaF PET/MRI was able to detect knee abnormalities unseen on MRI alone and simultaneously assessed metabolic and structural markers of knee OA across multiple tissues in the joint. Thus, it is a promising tool for detection of early metabolic changes in OA.
Clinical Studies with Anticoagulants that Have Changed Clinical Practice
Authors: Hirsh Jack , de Vries Tim A.C. , Eikelboom John W. , Bhagirath Vinai , Chan Noel C. 
Published: January 2023

AbstractAnticoagulant therapy is the cornerstone of treatment and prevention of arterial and venous thromboembolism. Taking a historical perspective, starting in the 1960s, and progressing through to 2022, we discuss key clinical trials of anticoagulants that have changed clinical practice, and examine obstacles encountered in bringing these anticoagulants to the clinic. The design of some of the early studies that shaped clinical practice was poor by current standards, but their results were influential because nothing better was available. Both heparin and vitamin K antagonists had been in clinical use for several decades before well-designed trials in the 1980s optimized their dosing and enhanced their safety and efficacy. Low-molecular-weight heparin then replaced unfractionated heparin because it had a more predictable dose–response and a longer half-life, thereby allowing it to be used conveniently in out-of-hospital settings. More recently, direct oral anticoagulants became the oral anticoagulants of choice for most indications because they were shown to be at least as safe and effective as vitamin K antagonists when used in fixed doses without the need for laboratory monitoring. The design of the trials that led to the approval of the direct oral anticoagulants was excellent, but further studies are required to optimize their dosing in selected patients who were underrepresented in these trials.