bluuebunny/crossref_metadata_2025_split huggingface dataset:
The prevalence and modifiable lifestyle factors of central obesity among white-collar workers of different genders: A cross-sectional study
Authors: Xiaoqian Dong , Li Ying , Li Jie , Duan Yinglong , Wang Sha , Kang Yue , Luo Yating , Wang Jiangang , Chen Zhiheng , Huang Dawei 
Published: May 2023

Abstract
Background: Central obesity is strongly associated with obesity-related and metabolic diseases, which is a common health problem in sedentary adults, particularly in women, but the mechanisms remain unclear. This study aimed to investigate the prevalence and factors associated with central obesity in white-collar workers Chinese population, and explore potential sex differences.
Methods: A cross-sectional study was conducted between 2017 and 2019 at two large general hospitals in northern and southern China. Totally 6,081 white-collar workers underwent a physical examination and completed an online health self-report questionnaire, which included demographic variables, lifestyle factors and blood lipid test. Multilevel logistic regression analysis was performed to assess the prevalence and factors of central obesity.
Results: A total of 4,973 male and 1,108 female white-collar workers were included in this study, and the incidence of central obesity was 67.5% and 30.1%, respectively.
In male white-collar workers, increasing age, chronic disease, higher levels of total cholesterol, salt intake and BEE, social engagement, eating spicy food and animal offal were risk factors for central obesity, while a higher HDL-C level, eating fish, and high vegetable intake were protective factors. In female white-collar workers, increasing age, higher total cholesterol level, higher BEE, and overeating were risk factors for central obesity, while a higher HDL-C level, and drinking milk were protective factors.
Conclusions: Central obesity was a significant public health concern and the prevalence was high in Chinese adults. Healthy lifestyles and dietary measures to control the rates of central obesity should be undertaken to circumvent the growing disease burden in Chinese people..
Interaction between physical activity and sleep quality at midterm after total knee arthroplasty: a Japanese retrospective cohort study
Authors: Hamai Satoshi , Harada Satoru , Tsushima Hidetoshi , Kozuma Ryutaro , Yamate Satoshi , Kawahara Shinya , Akasaki Yukio , Harada Tetsunari , Kokubu Yasuhiko , Konishi Toshiki , Nakashima Yasuharu 
Published: May 2023

Abstract
Purpose No report has clarified the frequency and interacting factors affecting sleep disturbance among Asian patients at midterm after total knee arthroplasty (TKA). This study aimed to evaluate the frequency of sleep disturbance at midterm after TKA in a Japanese cohort and to identify intervening factors for sleep. We hypothesized that residual knee pain and decreased physical activity negatively interact with sleep quality after TKA.Methods A total of 209 Japanese participants (average age: 77.1 ± 8.3 years; postoperative follow-up period: 4.5 ± 1.9 years) who underwent primary TKA for knee osteoarthritis were included in this study. Sleep quality, satisfaction, pain, physical activity, joint awareness, and mental condition were evaluated using the Pittsburgh Sleep Quality Index (PSQI), Knee Society Score (KSS) 2011, Forgotten Joint Score (FJS)-12, and 12-Item Short-Form Health Survey (SF-12) Mental Component Summary (MCS). Multivariate analysis was performed to determine the influencing factors on PSQI.Results The scores for the PSQI, satisfaction with pain level while lying in bed, pain during level walking, functional activity category in the KSS 2011, awareness of the artificial joint in bed at night in the FJS-12, and SF-12 MCS were 6.7 ± 3.0, 5.8 ± 1.8, 1.6 ± 2.3, 62 ± 22, 1.5 ± 1.4, and 56 ± 9.3 on average, respectively. Sleep disturbance (PSQI ≥ 5.5) occurred in 54% of the Japanese participants. Multivariate analysis revealed that high activity was a significant interacting factor for sleep quality improvement (p < .05).Conclusion Decreased physical activity, not residual knee pain, negatively interacted with sleep quality. The sleep disturbance rate was high during the middle postoperative period after TKA in the Japanese cohort, suggesting that interventions that promote daytime exercises may be effective.
A clinical model to predict the risk of distant metastasis in intrahepatic cholangiocarcinoma and to explore the benefits of radiotherapy and chemotherapy
Authors: Zhang Yan , Lin yun , Wang Yan-Chun , Lin Hang-Ying , Guo Wang-Ting , Chen Shao-Ting , Yao Xia , Wu Zhang-Cai , Wang Xiao-Yang , Chen Xi , Li Dong-Liang 
Published: May 2023

Abstract
Objective: To develop a clinical prediction model for the risk of distant metastasis in patients with intrahepatic cholangiocarcinoma, to assess the risk of distant metastasis and prognosis of patients, and to explore the efficacy of radiotherapy and chemotherapy in people with different risks of distant metastasis.
Method: Clinicopathological data of 15,497 patients diagnosed with intrahepatic cholangiocarcinoma from January 2000 to December 2018were extracted from the Surveillance, Epidemiology, and End Results (SEER) database, and all eligible patients were randomly divided into a training cohort and a validation cohort in a 7:3 ratio. Univariate and multivariate logistic regression analyses were performed on the training cohort to identify independent factors for distant metastasis. A prediction model for distant metastasis in patients with intrahepatic ductal carcinoma was constructed based on the independent risk factors for distant metastasis. Receiver Operating Characteristic (ROC) and calibration curves were used to assess the predictive accuracy of the model, and Decision Curve Analysis (DCA) was used to evaluate the clinical utility of the column line graphs.Tumor distant metastasis risk stratification and subgroup survival analysis were performed according to the model, and the benefits of radiotherapy and chemotherapy were explored with the help of the model.
Result: Multivariable logistic analysis showed that age, T-stage, N-stage, degree of differentiation, and tumor size were independent risk factors for distant metastasis. The area under the ROC curve (AUC value) was 0.733 (CI95%: 0.713-0.753) and 0.750 (CI95%:0.721-0.780) for the training and validation sets, respectively, and the calibration curves indicated good agreement between predicted and actual values, and the decision curves showed good clinical utility of the model.Subgroup survival analysis suggested that the prognosis is poor in the intermediate and high risk groups, and that radiotherapy and chemotherapy canimprove the prognosis in these groups, with no benefit for the low risk groups.
Conclusion: The prediction model of distant metastasis in patients with intrahepatic cholangiocarcinoma based on the SEER database has good prediction accuracy, which helps physicians to assess the risk of distant metastasis and prognosis of patients, thus providing a reference for individualized clinical treatment decisions for patients. Chemotherapy and radiotherapy can significantly improve the survival prognosis of patients with intermediate and high risk of distant metastasis.
Night-time hot spring bathing is associated with a lower systolic blood pressure among Japanese older adults: A single-institution retrospective cohort study
Authors: Yamasaki Satoshi , Tokunou Tomotake , Maeda Toyoki , Horiuchi Takahiko 
Published: May 2023

AbstractHot spring bathing is practiced helping manage hypertension. We analyzed patients’ medical records to investigate the preventive effects of hot spring bathing on hypertension with the aim of identifying a novel approach to prevent and manage hypertension. The study cohort comprised 99 patients aged ≥ 65 years who were admitted to the Department of Internal Medicine of Kyushu University Beppu Hospital between December 1, 2021, and November 30, 2022; who could walk by themselves; and who used hot springs for 3 days or more. We retrospectively calculated the odds ratios (OR) and 95% confidence intervals (CIs) of the influence of night-time hot spring bathing using the multivariate logistic regression model. The changes in both systolic and diastolic blood pressure were significantly decreased in the night-time bathing group (n = 21) compared to those in the noontime (n = 26) and afternoon (n = 52) groups. The female sex (OR 7.540; 95% CI 4.280–13.30), hypertension (OR 0.397; 95% CI 0.245–0.644), and arrhythmia (OR 12.20; 95% CI 5.340–28.00) were independently and significantly associated with night-time hot spring bathing. Night-time hot spring bathing was significantly associated with a reduced systolic blood pressure in older adults. Prospective randomized controlled trials on night-time hot spring bathing as a treatment for hypertension are warranted to investigate whether night-time hot spring bathing can prevent hypertension among adults aged ≥ 65 years.
Evaluation of the Ovicidal Activity and Fasciolicidal Activity of the Extract of Ethyl Acetate from Artemisia Ludoviciana Nutt. Spp. Mexicana and of Artemisinin Against Adult Parasites of Fasciola Hepatica
Authors: Ezeta-Miranda Alonso , Avila-Acevedo José Guillermo , Vera-Montenegro Yolanda , Francisco-Marquez Gerardo 
Published: May 2023

Abstract
The objective of this work was to evaluate the effect of the ethyl acetate extract of A. ludoviciana and artemisinin against adult parasites and eggs of F. hepatica. Extract from A. ludoviciana were obtained by using ethyl acetate. To carry out the ovicidal assay, cell culture boxes were used, and 90 to 110 F. hepatica eggs were placed in each well. The eggs were exposed in triplicate to concentrations of 100, 200, 300, 400 and 500 mg/L of the extract, and they were incubated for 14 and 16 days at a temperature of 28°C and 80% humidity. Adult flukes were exposed to concentrations of 125, 250, 375 and 500 mg/L ethyl acetate extract of A. ludoviciana. Additionally, triclabendazole was used as a reference drug at concentrations of 10 and 50 mg, and at the same time the response of artemisinin at concentrations of 10 and 20 mg was assessed. The results of the percentage of ovicidal action of the eggs exposed to triclabendazole showed 3.23% and 16.13% at 14 days of incubation, 3.89% and 17.03% at 16 days, artemisinin showed 57.75% and 65.95% at 14 days, 59.10% and 68.23% at 16 days. Finally ethyl acetate extract of A. ludoviciana showed 83.55% at 14 days and 93.65% at 16 days (P < 0.05). The fasciolicidal activities of triclabendazole and artemisinin showed 100% of efficacy at 24 hours of exposure. ethyl acetate extract of A. ludoviciana showed 100% of efficacy at 48 and 72 hours of exposure (P < 0.05).
Fluid evolution and related fluid–rock interactions of the Oligocene Zhuhai Sandstones in the Baiyun Sag, North Margin of the South China Sea
Authors: Tian Bing , Yuan Yihan , Tang Jun , Zuo Shanshan , Zheng Youwei , Liu Ming , Guo Cheng 
Published: May 2023

Abstract
The pore fluids control the diagenetic processes and storage spaces of the deep clastic rock reservoirs and have become a major area of interest within the fields of sedimentology and petroleum geology. This paper aims to relate diagenetic processes of the Oligocene Zhuhai sandstones in the Baiyun Sag, to pore fluids varying with burial depth. The types and distribution patterns of authigenic minerals are investigated by analyzing petrographic, mineralogical, and geochemical features, to illustrate the originand flow patterns of pore fluids and their influences on reservoir diagenesis. Strong cementation of eogenetic carbonate cement near the sandstone–mudstone interface was a consequence of material migration from adjacent mudstones on a large scale. The pore fluids were mainly affected by microbial methanogenesis and carbonate mineral dissolution in adjacent mudstones during eogenesis. It was diffusively transported in a relatively open geochemical system within a local range. Support for this model is provided by heavier stable isotopic values in eogenetic calcite and dolmite. Feldspar dissolution during early mesogenesis is spatially accompanied by the precipitation of authigenic quartz and ferroan carbonate cement. Pore fluids in this period were rich in organic acid and CO2, and its migration mechanism was diffusive transport. The obviously lighter carbon and oxygen isotopic compositions of ferroan calcite supports this deduction. During late mesogenesis, the input of deep hydrothermal fluid might be partly responsible for the precipitation of ankerite, barite and authigenic albite. Oil charge may inhibit the carbonate cementation and compaction, accordingly preserving porosity, and together with the authigenic kaolinite, might promote the reservoir from water wet to oil wet, to the benefit of oil entrapment. The findings reported here shed new light on the evaluation and prediction of sandstone reservoirs that have experienced multiple periods of fluid flow.
Gene selection for single cell RNA-seq data via fuzzy rough iterative computation model
Authors: Li Zhaowen , Zhang Jie , Wang Yuxian , Liu Fang , Wen Ching-Feng 
Published: May 2023

Abstract
A single cell gene decision space (scgd-space) means a real-valued decision information system that the samples, features and information values are cells, genes and gene expression values where gene expression data (ge-data) is single cell RNA-seq data (scrs-data), respectively. Because scrs-data have the characteristics of small samples, high dimension and noise, the existing gene selection methods based on an equivalence relation are often powerless for scrs-data owing to the strictness of the equality between gene expression values. This study explores fuzzy rough iterative based gene selection in a single cell gene decision space. In order to overcome the strictness of the equality between gene expression values, the equality between gene expression values is replaced by the distance between gene expression values, and the fuzzy symmetric relation on the cell set of an scgd-space are first established with the help of “The relationship between gene expression values is fed back to the gene set”. In this fuzzy symmetric relation, two variable parameters are introduced: one controls the similarity between cells, the other dominates the distance between gene expression values. Then, fuzzy rough approximations in an scgd-space are introduced. Moreover, some evaluation functions such as fuzzy rough approximations and dependency functions are presented. Next, fuzzy rough iterative computation model (F RIC-model) is given and a gene selection algorithm based on this model is designed. This model applies the iterative computation strategy to define some evaluation functions such as fuzzy positive region and fuzzy dependency. At last, the designed algorithm is testified in several publicly open scrs-data sets to estimate its performance. The experimental results show that the designed algorithm is more effective than some existing algorithms, is fast and does not occupy too much memory.
Buccolingual alveolar bone condition of mandibular molar distalization in skeletal class III patients
Authors: Jiang Liya , Weng Luxi , Xu Liqi , Lin Jun 
Published: May 2023

Abstract
Objective:
To investigate the alveolar bone condition of mandibular molar distalization in skeletal Class III patients from buccolingual direction.
Methods:
45 skeletal class III patients were recruited. The alveolar bone volume, buccal cortical bone thickness and lingual cortical bone thickness were measured in five planes from mesial to distal and at five depths from gingival to root. The effects of the gender of the patients, the second molar lingual inclination, and wisdom tooth on alveolar bone volume and cortical bone thickness were evaluated. To explore the effect of wisdom tooth extraction on alveolar bone condition, the measurements before and after wisdom tooth extraction were compared.
Results:
The impacted wisdom tooth had significantly greater alveolar bone volume and thicker buccal cortical bone at cervical third of molar, while the erupted wisdom tooth had greater alveolar bone volume at apical third. After wisdom tooth extraction, these advantages would weaken owing to the reconstruction of alveolar bone. Patients with lingual inclined molar were observed to own thicker lingual cortical bone. Male tended to have greater alveolar bone volume, but no significant differences were shown in this study.
Conclusions:
The growth of wisdom tooth and the second molar lingual inclination can effectively make the alveolar bone condition more favorable for mandibular molar distalization, but gender has trivial effects on alveolar bone condition. Shortly after the wisdom tooth extraction surgery, the better bone condition can be maintained.
Pandemic Exposure and Adolescent Anxiety: Roles of Negative Media Exposure and Negative Coping Styles
Authors: Chen Zhanjie , Li Qian , Li Tianchang , Chen Bo , Wang Jingxi , Zhen Rui 
Published: May 2023

AbstractThe COVID-19 pandemic threatened people’s mental health, especially for adolescents, because their adjustment mechanisms of cognition and emotion are not perfect. They are more likely to have psychological health problems such as anxiety. The existing researches have carried out relevant discussions on this issue, indicating that excessive exposure to public health emergency events and negative coping styles are important factors causing psychological and behavioral problems such as anxiety. In this study, self-report questionnaires were distributed to 983 middle school students from Hubei province in China. This study focused on the role of negative media exposure and negative coping styles, so as to reveal the mechanism of adolescent anxiety during the pandemic. The results showed that pandemic exposure had a predicative effect on adolescent anxiety. The mechanism of this effect included the direct effect of pandemic exposure, the indirect effect of negative media exposure and negative coping styles.
Drinking water temperatures altered serum metabolomics and fecal microbiome in a mouse model
Authors: Zhao Ziwei , An Yanjun , Li Yanyan 
Published: May 2023

Abstract
The diet temperature could potentially affect health outcomes. Our study designed the experiment using a mouse model to explore the effect of the drinking water temperature on physiological states. The results indicated that the administration of drinking water at two different temperatures (4℃ representing the cold water and 45℃ representing the warm water) did not significantly affect the food/water intake and body weight but altered serum metabolomics and fecal microbiome. Compared to the control (23℃), the administration of cold water and warm water were both found to affect the pyrimidine metabolism, as evidenced by the decreasing in serum metabolites of Uridine, Cytidine, Deoxyuridine, Dihydrothymine. Moreover, cold water altered fatty acid biosynthesis while warm water affected the pentose phosphate pathway (PPP) which was involved in carbohydrate metabolism. Regarding the gut microbiome, cold water and warm water both could increase the gut microbiome richness and diversity, reduce the F/B ratio, and promote the population of Bifidobacterium when compare to the control group. Meanwhile, cold water additionally increased the abundances of Alistipes, Acinetobacter, and Pseudochrobactrum while the warm water administration reduced the richness Alcaligenes, Coprococcus, Planctomyces, and Polaribacter. Our findings demonstrated that both cold and warm drinking water temperatures appear to alter pyrimidine metabolism and exhibit potential health benefits by increasing bacteria richness and diversity of gut microbiome, in particular the beneficial bacteria Bifidobacterium. Additionally, cold water administration was relevant to fatty acid metabolism while warm water could affect carbohydrate metabolism.
Theoretical-Simulation-Experimental Study on the Hybrid Lubrication Performance of Stepped Hydrostatic Thrust Bearing
Authors: Yu Xiaodong , Feng Yanan , Jiang Hui , Gao Weicheng , Shi Guangqiang , Jiao Jianhua , Dai Ruichun , Jia Wentao , Wang Junfeng 
Published: May 2023

Abstract
Based on static pressure support technology, hydrodynamic, statics theory and tribology theory, theoretical derivation, calculation, simulation, and experimental monitoring of the static pressure, dynamic pressure, total pressure, dynamic pressure ratio, and total temperature rise of the lubricating oil film were conducted. The characteristics of stepped hydrostatic thrust bearing clearance oil film hybrid lubrication were obtained for the first time using a combination of theory, simulation, and experiment. It is found that the static pressure and total pressure of the oil film meet the reduction modes of the Fourier yj function and Fourier yz function within the rotating speed of 0r/min-200r/min. Within the load range of 0t-30t, the static pressure and total pressure of the oil film conform to the growth pattern of the Fourier yj function and Fourier yz function with constant term slopes of 10200 and 12150, and intercepts of 127700 and 156700. The theoretical value of oil film dynamic pressure and rotational speed exhibit a linear growth relationship with a slope of 275.2. The simulation value and rotational speed follow the growth law of the Fourier y model and are basically not affected by the size of the load. As the rotational speed increases, the oil film temperature of the rectangle on the outer side of the oil pad presents a concave shape in the circumferential distribution, while the rectangle on the inner side presents a convex shape.
Construction of diversity panels of landrace rice collections in Myanmar
Authors: Yamagata Yoshiyuki , Furuta Tomoyuki , Saw Ohm Mar , Moe Sandar , Win Khin Thanda , Hlaing Moe Moe , Yasui Hideshi , Ashikari Motoyuki , Thein Min San , Yoshimura Atsushi 
Published: May 2023

Abstract
To meet the future demand of the global population, new varieties to adapt to regional climate changes such as salinity, drought, and submergence and new race emergence of pest disease and insects are expected to be developed for plant breeders. To facilitate efficient screening of germplasm and gene exploration on bi-parental cross populations and genome-wide association study (GWAS), the construction of a compact and genetically characterized germplasm platform is necessary in the National gene bank. In this study, genetic relationships of the representative core collections (CC) conserved in the National Seedbank of Myanmar were investigated using the genotyping-by-sequencing approach. It was found that the accessions were classified into the three clusters corresponding so-called japonica, indica, and aroma subpopulations. For efficient germplasm screening and gene exploration by GWAS on the indica landrace germplasm in Myanmar, a compact diversity panel designated “G” consisting of the 249 accessions was assembled, and genome-wide nucleotide variants were collected by the whole genome sequencing. The principal component analysis using genome-wide variants revealed that the selected accessions did not have an apparent population structure, but the first and second principal component scores correlated to the latitude and longitude, suggesting that latitude is the more causal factor of the geographical variation within the Myanmar landrace. When the reference genome of the leading variety in Myanmar was used, the mixed model genome-wide association analysis provided higher -log10(p) scores and detected seven peaks of apiculus pigmentation of spikelet. The five peak associations of the seven fall into the linkage disequllibrium blocks or neighbor blocks containing the isolated genes involved in anthocyanin pigmentation in rice. These results demonstrated that the combination of the landrace GWAS of the National seed banks and reference sequences genetically related to the landrace provide better research environments in characterization and gene exploration.