bluuebunny/crossref_metadata_2025_split huggingface dataset:
Caracterização química, mineralógica e geotécnica de sedimentos da formação barreiras e pós-barreiras - litoral sul do Rio Grande do Norte, Brasil
Authors: Freire Lisyanne Vasconcelos , Júnior Olavo Francisco dos Santos , Ingunza Maria del Pilar Durante , Chaves Leonardo Flamarion Marques , Neto Osvaldo de Freitas 
Published: December 2022

A Formação Barreiras, de origem sedimentar, se estende ao longo do litoral brasileiro e tem sido objeto de diversas pesquisas, devido sua extensão e variabilidade espacial, além de se encontrar numa região intensamente povoada e de elevado interesse econômico. Sobre ela encontra-se uma camada de sedimentos do Quaternário, denominados de Pós-Barreiras. O objetivo deste trabalho é o estudo das propriedades químicas, mineralógicas e geotécnicas de sedimentos da Formação Barreiras e Pós-Barreiras, localizadas no litoral sul do Rio Grande do Norte. Foram coletadas amostras de diferentes pontos para a realização de ensaios de fluorescência de raios-x, espectrofotometria de absorção atômica, difração de raios-x e análises através do microscópio eletrônico de varredura. As propriedades geotécnicas foram determinadas a partir de ensaios de granulometria, limites de liquidez e plasticidade e massa específica dos sólidos. Os resultados das análises químicas apresentaram sílicio, alumínio e ferro como principais elementos químicos. Os sedimentos da Formação Barreiras apresentaram elevadas concentrações de ferro e ocorrência dos minerais quartzo, caulinita, hematita e goetita. Os sedimentos Pós-Barreiras apresentaram quartzo, nacrita e anatásio e foram classificados como SC ou SC-SM de baixa a média plasticidade.
PROCYONIDAE (CARNIVORA) IN A CAVE IN THE PARQUE NACIONAL DE UBAJARA, NORTHEAST OF BRAZIL (EOHOLOCENE)
Authors: Oliveira Paulo Victor , Viana Maria Somália Sales , Cardoso Gina , Freire Gustavo Batista Matos 
Published: December 2022

The most recent procyonids of Brazil came from North America at the end of the Pleistocene. This work presents and describes the first carnivore record (Procyonidae Gray, 1825) found in a cave deposit and collected from dated sediments in northeastern Brazil. The collection was made during an excavation mission at the Gruta do Urso Fóssil, Parque Nacional de Ubajara, State of Ceará. The studied material was found at a depth of 0.8 m. Using the Thermoluminescence and Optically Stimulated Luminescence methods, the material was dated to ± 8,450 years BP. The animal is represented by a maxilla fragment with a complete right M2 and can be attributed to Procyon cancrivorus (Cuvier, 1798). The presence of this species in this area suggests that the environmental dynamics of the region has been harmonious and conserved for, at least, the last 8,000 years.
Estudo da estabilidade de taludes em Petropolis (RJ) através dos métodos geofísicos GPR e ERT
Authors: Nascimento Gleide Alencar do , Silva Adrianna Jakeline 
Published: December 2022

O deslizamento de taludes é um fenômeno natural que ocorre em todo mundo e que pode ocasionar perda de vidas humanas e materiais. Sendo a possibilidade de se avaliar essas áreas de risco através dos métodos geofísicos. Nesse estudo foram utilizados os métodos Radar de Penetração do Solo (GPR) e Tomografia Elétrica de Resistividade (ERT) na Rua Mato Grosso, no bairro de Quitandinha, Petrópolis (RJ), a qual é suscetível a deslizamentos de taludes. O GPR é fundamentado na propagação das ondas eletromagnéticas com frequências entre 10 e 6000 MHz, na aquisição de dados foi utilizado uma antena de 200 MHz e o processamento de dados realizados no programa REFLEXW. O ERT é baseada na diferença de potencial elétrico dos campos elétricos naturais ou artificias, foram utilizados para aquisição de dados 24 eletrodos, com processamento de dados no programa RES2DINV e uma simulação de dados no programa RES2DMOD. Nos resultados obtidos foram constatados, diferença de solo consolidado e inconsolidado em aproximadamente 1,5 m de profundidade que pode gerar futuros deslocamentos de terra, a presença de blocos de diversos tamanhos espalhados pela área sendo indícios de que a área já sofreu com deslizamentos de terras, pontos de drenagem e acúmulo de água elevando os riscos de deslizamento. O uso de métodos geofísicos vem a contribuir na análise da instabilidade de taludes e ajudar a evitar futuros desastres.
Interligações da voz falada e voz cantada para o ator: conceitos, estudo e reflexão
Authors: Santos Marcos 
Published: December 2022

A voz é um elemento individual de cada pessoa e um elemento poderoso na caracterização teatral, a voz cantada faz também parte da formação teatral. Neste estudo pretende-se estudar a ligação entre a voz cantada e a voz falada, as suas influências, os pontos comuns e as suas interligações. Para melhor compreender as interligações foram analisados os autores de referência de ambas as vertentes vocais nos critérios de projeção, articulação e respiração. Foi utilizado como objeto de estudo um grupo de alunos de Artes cénicas sendo aplicado metodologias de voz cantada e voz falada.
Máscaras improváveis: procedimentos para criação de si em tempos pandêmicos
Authors: Bodstein Gabriel 
Published: December 2022

Relato de experiência elaborado no contexto do 3º Colóquio Internacional Mascaramento na Cena Expandida. Descreve o processo de desenvolvimento da pesquisa de mestrado intitulada Práticas de atuação com a máscara teatral: das personagens-tipo às máscaras improváveis, em especial um recorte que abarca a investigação de procedimentos de mascaramento para criação de si no período do isolamento social imposto pela pandemia da COVID-19.
PALAVRAS-CHAVE: Máscara teatral; Atuação; Confecção; Pedagogia.
Isorhynchophylline Regulates the Circadian Rhythm of the Hypothalamus in
Spontaneously Hypertensive Rats to Treat Hypertension
Authors: Li Yunlun , Jiang Haiqiang , Wang Danyang , Sun Mengjia , Liu Yuecheng , Wang Lihua , Li Chao 
Published: December 2022

Background:
The neurotransmitter metabolism in spontaneously hypertensive rats (SHR) is disordered,
and these disturbances in neurotransmitter levels can further exacerbate the development of hypertension.
Neurotransmitters can affect the expression of circadian clock genes.

Objective:
To clarify the time-dependent internal mechanism of the imbalance of the target neurotransmitter
metabolic rhythm of spontaneously hypertensive rats, the circadian research was carried out by the method of
targeted metabolomics and molecular biology technology.

Methods:
We have explored the mechanism of isorhynchophylline regulating the circadian rhythm through the
ERK signaling pathway and thus treating hypertension by detecting the changes of central hypothalamic biological
clock rhythm genes after isorhynchophylline intervention, from hypothalamic neurotransmitter rhythmicity.

Results:
The expression of rhythm genes in normal rats showed a certain rhythm at 6 time points, while the expression
of rhythm genes in model rats decreased, and the gene rhythm returned to normal after isorhynchophylline
treatment. Cosine analysis of 12 neurotransmitters in hypothalamus showed that there were 6 rhythmic neurotransmitters
in the normal group, while in the model group, 4 of the 6 neurotransmitters lost their rhythmicity,
and the rhythmicity returned to normal after isorhynchophylline intervention. Compared with the normal group,
the expression of ERK protein in the model group increased significantly and decreased after isorhynchophylline
treatment.

Conclusion:
The mechanism of isorhynchophylline treating hypertension is not only the regulation of serum
neurotransmitters rhythm, but also acting on rhythm genes in the feedback loop of the central biological clock.
Biological and Pharmacological Properties of Myrtenol: A Review
Authors: Mrabti Hanae Naceiri , Jaouadi Imane , Zeouk Ikrame , Ghchime Rokia , El Menyiy Naoual , Omari Nasreddine El , Balahbib Abdelaali , Al-Mijalli Samiah H. , Abdallah Emad M. , El-Shazly Mohamed , Zengin Gokhan , Bouyahya Abdelhakim 
Published: December 2022

Abstract:
Myrtenol (C10H16O) is a volatile compound belonging to the terpenoid family of monocyclic monoterpenes.
It is one of the essential oils constituents of several aromatic plants, including the genera Myrtus, Tanacetum,
Artemisia, Hyssopus, and Rhodiola. The oxidation of α-pinene can produce it. Several reports demonstrated
the pharmacological properties of myrtenol, including its antioxidant, antibacterial, antifungal, antidiabetic,
anxiolytic, and gastroprotective activities. In this review, we discussed and highlighted in depth the pharmacological
activities, cellular and molecular, providing insight into the mechanisms of myrtenol. In light of this
finding, the interesting biological activities and abundance of myrtenol in nature suggests its potential applications
in medicinal settings in the fight against various diseases.
The Health-promoting Potential of Edible Mushroom Proteins
Authors: Sousa Ana Sofia , Araújo-Rodrigues Helena , Pintado Manuela Estevez 
Published: December 2022

Abstract:
Edible mushrooms have been classified as “next-generation food” due to their high nutritional value
coupled with their biological and functional potential. The most extensively studied and reported mushroom
macromolecules are polysaccharides. However, macrofungi proteins and peptides are also a representative and
significant bioactive group. Several factors such as species, substrate composition and harvest time significantly
impact the mushroom protein content, typically ranging between 19 and 35% on a dry weight basis. Proteins
work based on their shape and structure. Numerous extraction methods, including chemical and non-conventional,
and their implications on protein yield and stability will be discussed. Beyond their biological potential, a
great advantage of mushroom proteins is their uniqueness, as they often differ from animal, vegetable, and microbial
proteins. According to recently published reports, the most relevant mushroom bioactive proteins and
peptides include lectins, fungal immunomodulatory proteins, ubiquitin-like proteins, and proteins possessing enzymatic
activity such as ribonucleases laccases, and other enzymes and ergothioneine. These are reported as antioxidant,
antiviral, antifungal, antibacterial, antihypertensive, immunomodulatory, antitumour, antihypercholesterolemic
or antihyperlipidemic, antidiabetic and anti-inflammatory properties, which improved proteins and
peptides research interest and contributed to the increase of mushroom market value. This review provides an
overview of the most relevant biochemical and biological properties of the main protein groups in edible mushrooms,
explicitly focusing on their biomedical potential. Although mushrooms are a rich source of various proteins,
many of these molecules have yet to be identified and characterised. Accordingly, it is crucial to identify
and characterise new macromolecules of macrofungi origin, which opens an opportunity for further investigation
to identify new bioactives for food, nutraceutical, or medicinal applications.
Therapeutic Challenges in COVID-19
Authors: Maiti Amit K. 
Published: December 2022

Abstract:
SARS-CoV2 is a novel respiratory coronavirus and, understanding its molecular
mechanism is a prerequisite to developing effective treatment for COVID-19.
This RNA genome-carrying virus has a protein coat with spikes (S) that attaches to the
ACE2 receptor at the cell surface of human cells. Several repurposed drugs are used
to treat COVID-19 patients that are proven to be largely unsuccessful or have limited
success in reducing mortalities. Several vaccines are in use to reduce the viral load to
prevent developing symptoms. Major challenges to their efficacy include the inability of
antibody molecules to enter cells but remain effective in the bloodstream to kill the
virus. The efficacy of vaccines also depends on their neutralizing ability to constantly
evolve new virus strains due to novel mutations and evolutionary survival dynamics.
Taken together, SARS-CoV2 antibody vaccines may not be very effective and other
approaches based on genetic, genomic, and protein interactome could be fruitful to
identify therapeutic targets to reduce disease-related mortalities.
Probing the Neuro-psychological Changes Observed with the Administration
of COVID-19 Drugs
Authors: Chatterjee Indranath , Bansal Videsha 
Published: December 2022

Abstract:
The COVID-19 virus caused countless significant alterations in the human race, the most challenging of which was respiratory and neurological disorders. Several studies were conducted to find a robust therapy for the virus, which led to a slew of additional health issues. This study aims to understand the changes in the neurological system brought about by COVID-19 drugs and high-lights the drug-drug interaction between COVID-19 drugs and psychiatric drugs. Alongside this, the study focuses on the neuropsychological changes in three critical mental disorders, such as schizo-phrenia, Alzheimer’s disease, and Parkinson’s disease. The comprehensive and narrative review be-ing performed in this paper, has brought together the relevant work done on the association of COVID-19 drugs and changes in the neurological system. For this study, a systematic search was performed on several databases such as PubMed, Scopus, and Web of Science. This study also con-solidates shreds of evidence about the challenges confronted by patients having disorders like Schizophrenia, Alzheimer’s disease, and Parkinson's disease. This review is based on the studies done on COVID-19 drugs from mid-2020 to date. We have identified some scopes of crucial future opportunities which could add more depth to the current knowledge on the association of COVID-19 drugs and the changes in the neurological system. This study may present scope for future work to investigate the pathophysiological changes of these disorders due to COVID-19.
Highly Efficient Visible Light Assisted Synthesis of Perimidines under
Catalyst-free and Room Temperature Conditions
Authors: Agarwal Shikha , Patel Isha , Sahiba Nusrat , Soni Jay 
Published: December 2022

Abstract:
Visible light has come to the fore in organic chemistry as a cheap and readily available energy
source. Energy transfer reactions represent the future directions for the development of practical and
scalable industrial reactions with several environmental benefits. A facile, economic, and visible light
(CFL) induced synthesis of perimidines has been established through a cyclo-condensation reaction of
1,8-diaminonaphthalene and aryl aldehydes with excellent yields (87-100%) in a short span of time. The
present method has several merits a highly efficient, greener, high atom economy, no need of external
heating and other instrumental setups, no need for a catalyst, and no tedious purification process.
Efficacy and Safety of Faster Aspart in Comparison to Insulin Aspart
Among Indian Women with Gestational Diabetes
Authors: Ghosh Aneesh 
Published: December 2022

Aims:
The present study aimed to compare the pregnancy outcomes, efficacy, and safety
of faster aspart with insulin aspart among Indian women with gestational diabetes.

Background:
In several countries, fast-acting insulin aspart (faster aspart) has been approved for
use in pregnancy. There is a lack of data related to maternal glycemic control and fetal and perinatal
outcomes with faster aspart in gestational diabetes among the Indian population.

Objective:
To compare and evaluate the efficacy and safety of faster aspart and insulin aspart in the
management of gestational diabetes.

Methods:
This retrospective study evaluated the medical records of 60 pregnant women diagnosed
with gestational diabetes and managed with faster aspart or insulin aspart at a tertiary care center,
between March 2019 and September 2020. Self-monitored blood glucose levels recorded at 4
timepoints (fasting, and 1 hour post breakfast, lunch, and dinner) during 6 consecutive days any
time before delivery were analyzed. Pregnancy and neonatal outcomes across both groups were
compared.

Results:
The mean postprandial glucose value following dinner was significantly lesser in the faster
aspart group compared to the insulin aspart group (123.61 ± 2.52 mg/dL vs. 125.87 ± 2.98
mg/dL, respectively; p=0.0024). Women in the faster aspart group had significantly lower glycemic
variability (fluctuations). Lesser number of hypoglycemic events were noted in the faster aspart
group (10 vs 20; p=0.0595).

Conclusion:
Faster aspart was associated with better glycemic control compared to insulin aspart
among women with gestational diabetes. Further large-scale studies are needed to validate the outcomes.
A Review of COVID-19 Diagnostic Approaches in Computer Vision
Authors: Zalluhoğlu Cemil 
Published: December 2022

Abstract:
Computer vision has proven that it can solve many problems in the field of health in recent
years. Processing the data obtained from the patients provided benefits in both disease detection and
follow-up and control mechanisms. Studies on the use of computer vision for COVID-19, which is one
of the biggest global health problems of the past years, are increasing daily. This study includes a preliminary
review of COVID-19 computer vision research conducted in recent years. This review aims
to help researchers who want to work in this field.
Synthesis and Molecular Docking of New N-Acyl Hydrazones-
Benzimidazole as hCA I and II Inhibitors
Authors: Küçükoğlu Kaan , Çevik Ulviye Acar , Nadaroglu Hayrunnisa , Celik Ismail , Işık Ayşen , Bostancı Hayrani Eren , Özkay Yusuf , Kaplancıklı Zafer Asım 
Published: December 2022

Background:
The carbonic anhydrases (CAs) which are found in most living organisms is
a member of the zinc-containing metalloenzyme family. The abnormal levels and activities are frequently
associated with various diseases therefore CAs have become an attractive target for the design
of inhibitors or activators that can be used in the treatment of those diseases.

Methods:
Herein, we have designed and synthesized new benzimidazole-hydrazone derivatives to
investigate the effects of these synthesized compounds on CA isoenzymes. Chemical structures of
synthesized compounds were confirmed by 1H NMR, 13C NMR, and HRMS. The synthetic derivatives
were screened for their inhibitory potential against carbonic anhydrase I and II by in vitro assay.

Results:
These compounds have IC50 values of 5.156-1.684 μM (hCA I) and 4.334-2.188 μM (hCA
II). Inhibition types and Ki values of the compounds were determined. The Ki values of the compounds
were 5.44 ± 0.14 μM-0.299 ± 0.01 μM (hCA I) and 3.699 ± 0.041 μM-1.507 ± 0.01 μM
(hCA II). The synthetic compounds displayed inhibitory action comparable to that of the clinically
utilized reference substance, acetazolamide. According to this, compound 3p was the most effective
molecule with an IC50 value of 1.684 μM. Accordingly, the type of inhibition was noncompetitive
and the Ki value was 0.299 ± 0.01 μM.

Conclusion:
According to the in vitro test results, detailed protein-ligand interactions of the compound
3p, which is more active against hCA I than standard azithromycin (AZM), were analyzed. In
addition, the cytotoxic effects of the compounds on the L929 healthy cell line were evaluated.
Separation and Characterization of the Components and Impurities in
Policresulen Solution using LC-Q-TOF MS
Authors: Shi Yunfeng , Yao Qi , Lin Liqin , Ren Xiaojuan , Ai Jie , Chen Yue 
Published: December 2022

Background:
As an external medicine, policresulen solution didn't get much attention throughout the world. From the paper which had been published yet, there has been no report concerning other unknown impurities in the policresulen solution. Four known components have been identified as well as quantified, however, as long as people’s concern for drug safety increases rapidly, there still remain impurities to be studied.

Objective:
This paper focuses on the separation and characterization of the impurities in the policresulen solution, which is critical for controlling the production of this drug.

Methods:
The components and impurities in the policresulen solution were separated and characterized using HPLC coupled with Q-TOF mass spectrometry. An ACE EXCEL 5 C18-PFP column (4.6 mm×250 mm, 5 μm) was used, and the mobile phases were 0.01 M ammonium acetate solution and methanol.

Results:
21 previously unknown impurities were separated and characterized in a policresulen solution, and the structures were proposed based on the MS/MS fragmentation data.

Conclusions:
Based on the characterization of impurities, this study showed that there remain lots of oligomers in the policresulen solution, apart from four known components. This study could be used for further analytical analysis of the policresulen solution, which could improve the quality control of the policresulen solution and other preparations recommended in pharmacopoeias.
The Neuroprotective Role of BCG Vaccine in Movement Disorders: A Review
Authors: Yedke Narhari Gangaram , Kumar Puneet 
Published: December 2022

Abstract:
Bacillus Calmette-Guérin (BCG) is the first developed vaccine to prevent tuberculosis (TB)
and is the world's most widely used vaccine. It has a reconcilable defense in opposition to tuberculosis,
meningitis, and miliary disease in children but changeable protection against pulmonary TB. Immune
activation is responsible for regulating neural development by activating it. The effect of the BCG
vaccine on neuronal disorders due to subordinate immune provocation is useful. BCG vaccine can
prevent neuronal degeneration in different neurological disorders by provoking auto-reactive T-cells.
In the case of TB, CD4+ T-cells effectively protect the immune response by protecting the central defense.
Because of the preceding fact, BCG induces protection by creating precise T-cells like CD4+
T-cells and CD8+ T-cells. Hence, vaccination-induced protection generates specific T-cells and CD4+
T-cells, and CD8+ T-cells. The BCG vaccine may have an essential effect on motor disorders and play
a crucial role in neuroprotective management. The present review describes how the BCG vaccine
might be interrelated with motor disorders and play a key role in such diseases.
Conservative Restorative Management of External Cervical Tooth Resorption: A Case Report
Authors: Alkuwaiti Elaf A. , Alzahrani Nada M. , Bugshan Amr S. , Alsaati Muhammed A. , Almulhim Khalid S. 
Published: December 2022

Background:
External cervical resorption (ECR) is one of the subclassifications of external root resorption. The etiology of ECR is still unclear. In most cases, it is not evident and asymptomatic before the involvement of the pulp.

Case presentation:
This paper reports a case of ECR in the mandibular right first molar of a 24-year-old patient who presented with an asymptomatic pink tooth. A two-dimensional radiograph and Cone beam computed tomography (CBCT) showed cervical resorption penetrating at the cementoenamel junction level from the mesio-lingual aspect. It approximates the pulp horn coronally within the lingual dentinal wall.

Discussion:
The treatment of the case involved debridement of the resorptive defect and Mineral Trioxide Aggregate (MTA) was applied as a direct pulp capping, glass ionomer as a base, and the tooth was restored using composite resin restoration. After 6-months of follow-up, the radiographic examination showed healthy bone and periodontal structures with no evidence of periapical pathology.

Conclusion:
ECR is an aggressive and invasive lesion that acts silently, requiring early diagnosis and treatment for a successful outcome. The lesion size, location, and accessibility are the main factors affecting the successful treatment of ECR.