bluuebunny/crossref_metadata_2025_split huggingface dataset:
The correlates of post-surgical haematoma in older adults with proximal femoral fractures
Authors: Ruggiero Carmelinda , Pioli Giulio , Petruccelli Rosario , Baroni Marta , Prampolini Raffaella , Pignedoli Paolo , Antinolfi Pierluigi , Rinonapoli Giuseppe , Cappa Michele , Boccardi Virginia , Bendini Chiara , Mecocci Patrizia , Caraffa Auro , Sabetta Ettore 
Published: February 2023

Abstract
Background
Little is known about the incidence of haematoma, and clinical correlates among orthogeriatric patients.

Aims
This study aims to describe the incidence of haematoma after surgical repair of hip fracture and to identify the clinical correlates of haematoma among orthogeriatric patients.

Methods
Two orthopaedic surgeons and a dedicated operator using ultrasound technique, each other in blindness, evaluated 154 orthogeriatric patients during their hospital stay. All patients received a comprehensive geriatric assessment. We investigated the concordance between clinical diagnosis and ultrasound detection of haematoma, and then we explored the clinical correlates of the onset of post-surgical haematoma.

Results
Blood effusion at the surgical site was detected in 77 (50%) patients using ultrasound technique; orthopaedic surgeons reached a clinical agreement about post-surgical haematoma in 18 (23%) patients. The sensitivity of clinical evaluation was 0.66, and the specificity was 0.70. Independent of age, clinical, pharmacological, and surgical confounders, proton pump inhibitors (PPIs) were associated with post-surgical haematoma (OR 2.28; 95% CI 1.15–4.49). A tendency towards association was observed between selective serotonin reuptake inhibitors and post-surgical haematoma (OR 2.10; 95% CI 0.97–4.54),

Conclusions
Half of older patients undergoing surgical repair of proximal femoral fracture develop a post-surgical haematoma. Clinical assessment, even if made by senior orthopaedic surgeons, underestimates the actual occurrence of post-surgical haematoma compared to ultrasound detection. Ultrasound technique may help to detect haematoma larger than 15 mm better than clinical assessment. PPIs’s use is a risk factor for post-surgical haematoma independent of several medical and surgical confounders.
Starved lubrication analysis of angular contact ball bearing based on a multi-degree-of-freedom tribo-dynamic model
Authors: Wen Chengwei , Meng Xianghui , Gu Jiaming , Xiao Lin , Jiang Shuang , Bi Hanbing 
Published: February 2023

AbstractWhen the oil supply is not adequate to maintain the ideal lubrication, angular contact ball bearing will enter into the starved lubrication regime resulting in the potential performance degradation and consequently the severe failures. To study the effects of starved lubrication on the performance of angular contact ball bearing, this paper first proposes a multi-degree-of-freedom (DOF) tribo-dynamic model by introducing five-DOF inner ring, six-DOF balls, and six-DOF cage. The model considers the starved lubrication in the ball-raceway contact and the full multi-body interactions between the bearing components. With different ball-raceway starvation degrees being analyzed, the effects of starved lubrication on the bearing tribo-dynamic performance are first revealed. By comparison, it is found that the oil film thickness, the skidding performance, and the traction forces in the ball-raceway contact are significantly influenced by the starvation degrees. It is also found that the starvation-induced change of the ball-pocket contact force is dramatical under combined loads, and the maximum contact force under this load condition increases with the increasing starvation degrees.
Surface-functionalized design of blood-contacting biomaterials for preventing coagulation and promoting hemostasis
Authors: Wang Yi , Zhai Weijie , Cheng Shujie , Li Jinghua , Zhang Hongyu 
Published: February 2023

AbstractThe anticoagulation and hemostatic properties of blood-contacting materials are opposite lines of research, but their realization mechanisms are inspired by each other. Contact between blood and implantable biomaterials is a classic problem in tribological research, as both antithrombotic and hemostatic materials are closely associated with this problem. Thrombus formation on the surfaces of blood-contacting biomedical devices can detrimentally affect their performance and patient life, so specific surface functionalization is required. Currently, intensive research has focused on the development of super-lubricated or super-hydrophobic coatings, as well as coatings that deliver antithrombotic drugs. In addition, hemostatic biomaterials with porous structures, biochemical substances, and strongly adhesive hydrogels can be used to achieve rapid and effective hemostasis via physical or biochemical mechanisms. This article reviews methods of preparing anticoagulant coatings on material surfaces and the current status of rapid hemostatic materials. It also summarizes fundamental concepts for the design and synthesis of anticoagulant and hemostatic materials by discussing thrombosis and hemostasis mechanisms in biomedical devices and normal organisms. Because there are relatively few reports reviewing the progress in surface-functionalized design for anticoagulation and hemostasis, it is anticipated that this review can provide a useful summary of the applications of both bio-adhesion and bio-lubrication techniques in the field of biomedical engineering.
Parathyroid diseases and metabolic syndrome
Authors: Modica R. , Liccardi A. , Minotta R. , Benevento E. , Cannavale G. , Colao A. 
Published: February 2023

Abstract
Purpose
Parathyroid diseases are related to parathyroid hormone (PTH) dysregulation by parathyroid cells or alteration of PTH function. They include hyperparathyroidism (PTH excess), hypoparathyroidism (PTH deficiency) and pseudohypoparathyroidism (PTH resistance). Little is known about correlation between parathyroid diseases and metabolic syndrome (MetS).

Methods
An electronic-based search using PubMed was performed until October 2022 and articles were selected based on relevance of title, abstract, English language and publication in peer-reviewed journals.

Results
Possible association between PTH alterations and the diverse manifestation of MetS have been proposed and it could be supposed that MetS may negatively influence parathyroid diseases. Available data show significant association for hyperparathyroidism and pseudohypoparathyroidism.

Conclusions
This review highlights the possible implications between MetS and parathyroid diseases. Given the increasing MetS global prevalence and the higher parathyroid diseases awareness and diagnosis, it may be interesting to further explore the possible role of alterations in parathyroid homeostasis in the development of MetS components with dedicated prospective studies.
Assessment of uncertainties in a complex modeling chain for predicting reservoir sedimentation under changing climate
Authors: Pesci María Herminia , Mouris Kilian , Haun Stefan , Förster Kristian 
Published: February 2023

AbstractLong-term predictions of reservoir sedimentation require an objective consideration of the preceding catchment processes. In this study, we apply a complex modeling chain to predict sedimentation processes in the Banja reservoir (Albania). The modeling chain consists of the water balance model WaSiM, the soil erosion and sediment transport model combination RUSLE-SEDD, and the 3d hydro-morphodynamic reservoir model SSIIM2 to accurately represent all relevant physical processes. Furthermore, an ensemble of climate models is used to analyze future scenarios. Although the capabilities of each model enable us to obtain satisfying results, the propagation of uncertainties in the modeling chain cannot be neglected. Hence, approximate model parameter uncertainties are quantified with the First-Order Second-Moment (FOSM) method. Another source of uncertainty for long-term predictions is the spread of climate projections. Thus, we compared both sources of uncertainties and found that the uncertainties generated by climate projections are 408% (for runoff), 539% (for sediment yield), and 272% (for bed elevation in the reservoir) larger than the model parameter uncertainties. We conclude that (i) FOSM is a suitable method for quantifying approximate parameter uncertainties in a complex modeling chain, (ii) the model parameter uncertainties are smaller than the spread of climate projections, and (iii) these uncertainties are of the same order of magnitude as the change signal for the investigated low-emission scenario. Thus, the proposed method might support modelers to communicate different sources of uncertainty in complex modeling chains, including climate impact models.
On the estimation of the jump activity index in the case of random observation times
Authors: Theopold Adrian , Vetter Mathias 
Published: February 2023

AbstractWe propose a nonparametric estimator of the jump activity index $$\beta $$
β
of a pure-jump semimartingale X driven by a $$\beta $$
β
-stable process when the underlying observations are coming from a high-frequency setting at irregular times. The proposed estimator is based on an empirical characteristic function using rescaled increments of X, with a limit that depends in a complicated way on $$\beta $$
β
and the distribution of the sampling scheme. Utilising an asymptotic expansion we derive a consistent estimator for $$\beta $$
β
and prove an associated central limit theorem.
Stress distribution in an infinite plate with discontinuities like elliptical or circular hole by boundary force method
Authors: Badiger Shrikrishna , D. S. Ramakrishna 
Published: February 2023

AbstractThis paper deals with the boundary force method to determine the stress distribution in an infinite plate subjected to uni-axial tension having elliptical or circular hole. The elasticity solution for a point force in an infinite plate is used as the fundamental solution. The boundary conditions are satisfied in terms of the resultant forces. Stress distribution obtained by boundary force method is validated against the results from analytical equations. Traction free boundary condition is weakly satisfied. Hoop stress closely follow the results from analytical equations (AE). Accurate values of stress concentration factor are computed using boundary force method for different values of ratio of semimajor axis to semiminor axis.
Chromatin accessibility landscapes revealed the subgenome-divergent regulation networks during wheat grain development
Authors: Pei Hongcui , Li Yushan , Liu Yanhong , Liu Pan , Zhang Jialin , Ren Xueni , Lu Zefu 
Published: February 2023

AbstractDevelopment of wheat (Triticum aestivum L.) grain mainly depends on the processes of starch synthesis and storage protein accumulation, which are critical for grain yield and quality. However, the regulatory network underlying the transcriptional and physiological changes of grain development is still not clear. Here, we combined ATAC-seq and RNA-seq to discover the chromatin accessibility and gene expression dynamics during these processes. We found that the chromatin accessibility changes are tightly associated with differential transcriptomic expressions, and the proportion of distal ACRs was increased gradually during grain development. Specific transcription factor (TF) binding sites were enriched at different stages and were diversified among the 3 subgenomes. We further predicted the potential interactions between key TFs and genes related with starch and storage protein biosynthesis and found different copies of some key TFs played diversified roles. Overall, our findings have provided numerous resources and illustrated the regulatory network during wheat grain development, which would shed light on the improvement of wheat yields and qualities.
The use of antifoam agents to eliminate bubbles during biotechnological sample analysis
Authors: Bernau C. R. , Buyel J. F. 
Published: February 2023

AbstractColorimetric protein quantitation assays such as the Bradford method are susceptible to foaming when using manual or automated equipment, especially during mixing operations. The resulting bubbles cause unintended light scattering and, because they often persist for longer than the duration of the assay, can interfere with spectrometric sample analysis, for example in a 96-well plate reader at 585 nm. Here, we tested the ability of antifoam agents commonly used in biotechnology to reduce bubble formation when mixing Bradford reagent with protein samples from bioprocess development and production. We also assessed the impact of these agents on optical density at the assay-relevant wavelength to verify the fidelity of the readouts. We used a design of experiments approach to identify synergies between different antifoam agents, aiming to reduce the concentration needed to avoid foam formation and thus minimize any distortion of the assay results. Finally, we confirmed that antifoam-containing Bradford reagent retained its performance even after prolonged storage. We found that 0.15 g L−1 of Struktol J673A was sufficient to prevent foaming even when air was deliberately introduced into the samples. Furthermore, the modified Bradford reagent was stable for 4 weeks and did not distort the readout at 585 nm but only shifted it by ~ 0.1 dimensionless absorbance units. Therefore, our modified Bradford reagent will benefit biologists, biotechnologists and bioprocess engineers, especially those using automated workstations, because it improves the robustness of the assay.
Mineral composites: stay-in-place formwork for concrete using foam 3D printing
Authors: Bedarf Patrick , Calvo-Barentin Cristian , Schulte Dinorah Martinez , Şenol Ayça , Jeoffroy Etienne , Dillenburger Benjamin 
Published: February 2023

AbstractOptimizing the shape of concrete construction elements is significant in reducing their material consumption and total weight while improving their functional performance. However, the resulting non-standard geometries are difficult and wasteful to fabricate with conventional formwork strategies. This paper presents the novel fabrication method of mineral foam 3D printing (F3DP) of bespoke lost formwork for non-standard, material-efficient, lightweight concrete elements. Many innovative formwork studies have shown that stay-in-place formwork can help to reduce waste and material consumption while adding functionality to building components. Foams are particularly suitable for this application because of their high strength-to-weight ratio, thermal resistance, and good machinability. F3DP allows the waste-free production of geometrically complex formwork elements without long lead times and production-specific tooling. This paper presents the material system and robotic F3DP setup with two experimental case studies: a perforated facade panel and an arched beam slab. Both cases use concrete as structural material and strategically placed custom-printed foam elements. In this first preliminary study, concrete savings of up to 50% and weight reduction of more than 60% could be achieved. This is competitive with standardized solutions such as hollow-core slabs but, in contrast, allows also for non-standard element geometries. Additional functionality, such as programmed perforation, acoustic absorption, and thermal insulation, could be added through the stay-in-place formwork. Moreover, the challenges and future developments of F3DP for sustainable building processes are discussed. Further studies are required to verify the findings. However, considering the urgent need for resource-efficient, low embodied-carbon solutions in the construction industry, this work is an important contribution to the next generation of high-performance building components.
Preclinical-to-Clinical Anti-Cancer Drug Response Prediction and Biomarker Identification Using TINDL
Authors: Hostallero David Earl , Wei Lixuan , Wang Liewei , Cairns Junmei , Emad Amin 
Published: February 2023

Abstract
Prediction of the response of cancer patients to different treatments and identification of biomarkers of drug response are two major goals of individualized medicine. Here, we developed a deep learning framework called TINDL, completely trained on preclinical cancer cell lines (CCLs), to predict the response of cancer patients to different treatments. TINDL utilizes a tissue-informed normalization to account for the tissue type and cancer type of the tumors and to reduce the statistical discrepancies between CCLs and patient tumors. Moreover, by making the deep learning black box interpretable, this model identifies a small set of genes whose expression levels are predictive of drug response in the trained model, enabling identification of biomarkers of drug response. Using data from two large databases of CCLs and cancer tumors, we showed that this model can distinguish between sensitive and resistant tumors for 10 (out of 14) drugs, outperforming various other machine learning models. In addition, our small interfering RNA (siRNA) knockdown experiments on 10 genes identified by this model for one of the drugs (tamoxifen) confirmed that tamoxifen sensitivity is substantially influenced by all of these genes in MCF7 cells, and seven of these genes in T47D cells. Furthermore, genes implicated for multiple drugs pointed to shared mechanism of action among drugs and suggested several important signaling pathways. In summary, this study provides a powerful deep learning framework for prediction of drug response and identification of biomarkers of drug response in cancer. The code can be accessed at https://github.com/ddhostallero/tindl.
Whole-Genome Duplication Reshaped Adaptive Evolution in a Relict Plant Species, Cyclocarya Paliurus
Authors: Qu Yinquan , Shang Xulan , Zeng Ziyan , Yu Yanhao , Bian Guoliang , Wang Wenling , Liu Li , Tian Li , Zhang Shengcheng , Wang Qian , Xie Dejin , Chen Xuequn , Liao Zhenyang , Wang Yibin , Qin Jian , Yang Wanxia , Sun Caowen , Fu Xiangxiang , Zhang Xingtan , Fang Shengzuo 
Published: February 2023

Abstract
Cyclocarya paliurus is a relict plant species that survived the last glacial period and shows a population expansion recently. Its leaves have been traditionally used to treat obesity and diabetes with the well-known active ingredient cyclocaric acid B. Here, we presented three C. paliurus genomes from two diploids with different flower morphs and one haplotype-resolved tetraploid assembly. Comparative genomic analysis revealed two rounds of recent whole-genome duplication events and identified 691 genes with dosage effects that likely contribute to adaptive evolution through enhanced photosynthesis and increased accumulation of triterpenoids. Re sequencing analysis of 45 C. paliurus individuals uncovered two bottlenecks, consistent with the known events of environmental changes, and many selectively swept genes involved in critical biological functions, including plant defense and secondary metabolite biosynthesis. We also proposed the biosynthesis pathway of cyclocaric acid B based on multi-omics data and identified key genes, in particular gibberellin-related genes, associated with the heterodichogamy in C. paliurus species. Our study sheds light on evolutionary history of C. paliurus and provides genomic resources to study the medicinal herbs.
Identifying RNA Modifications by Direct RNA Sequencing Reveals Complexity of Epitranscriptomic Dynamics in Rice
Authors: Yu Feng , Qi Huanhuan , Gao Li , Luo Sen , Njeri Damaris Rebecca , Ke Yinggen , Wu Wenhua , Yang Pingfang 
Published: February 2023

Abstract
Transcriptome analysis based on high-throughput sequencing of a cDNA library has been widely applied to functional genomic studies. However, the cDNA dependence of most RNA sequencing techniques constrains their ability to detect base modifications on RNA, which is an important element for the post-transcriptional regulation of gene expression. To comprehensively profile the N 6 -methyladenosine (m6A) and N 5 -methylcytosine (m5C) modifications on RNA, direct RNA sequencing (DRS) using the latest Oxford Nanopore Technology was applied to analyze the transcriptome of six tissues in rice. Approximately 94 million reads were generated, with an average length ranging from 619 nt to 1013 nt, and a total of 45,707 transcripts across 34,763 genes were detected. Expression profiles of transcripts at the isoform level were quantified among tissues. Transcriptome-wide mapping of m6A and m5C demonstrated that both modifications exhibited tissue-specific characteristics. The transcripts with m6A modifications tended to be modified by m5C, and the transcripts with modifications presented higher expression levels along with shorter poly(A) tails than transcripts without modifications, suggesting the complexity of gene expression regulation. Gene Ontology analysis demonstrated that m6A- and m5C-modified transcripts were involved in central metabolic pathways related to the life cycle, with modifications on the target genes selected in a tissue-specific manner. Furthermore, most modified sites were located within quantitative trait loci that control important agronomic traits, highlighting the value of cloning functional loci. The results provide new insights into the expression regulation complexity and data resource of the transcriptome and epitranscriptome, improving our understanding of the rice genome.
The Western Segment of the Precambrian Suture Between the Yangtze and Cathaysia Blocks: Constraints From Magnetotelluric Data in Southwest China
Authors: Xu Shan , Hu Xiangyun , Chen Chaojian , Yang Xin , Sun Heping 
Published: February 2023

AbstractThe western segment of the suture zone between the Yangtze and Cathaysia blocks, which is the most important tectonic boundary related to the formation and rifting of south China, is enigmatic and not fully understood due to the sporadic exposure of Precambrian strata and ophiolites. Three‐dimensional electrical resistivity models derived from inversion of magnetotelluric data identified a lithospheric‐scale conductive zone extending northeastwards beneath the Youjiang basin, which was interpreted as the western segment of the suture zone. The high conductivity and coincident high magnetic anomalies closely match the location of Carlin‐type gold deposits, which can be explained by fluids and gold‐bearing sulfide minerals in a fossil suture zone. Inconsistent with the southeast‐dip resolved at the eastern segment of the suture zone (the Jiangshan‐Shaoxing fault) in the earlier study, the slightly north‐dipping geometry at the western suture zone implies the reactivation by northward subduction and closure of the Paleo‐Tethys Ocean.
The 2022 Hormozgan Doublet Earthquake: Two Blind Thrusts‐Related Folding in Zagros Fold‐And‐Thrust Belt, Southeast Iran
Authors: Yang Ying‐Hui , Li Xiaoyun , Hu Jyr‐Ching , Song Jiawei , Zhao Jingjin , Yassaghi Ali , Pathier Erwan , Xu Qiang , Chen Qiang 
Published: February 2023

AbstractA doublet earthquake event including two main shocks with a magnitude larger than Mw 6.0 occurred on 1 July 2022 in the Zagros fold‐and‐thrust belt, southeast Iran. The coseismic InSAR deformation field shows that this event caused significant surface uplift due to fault‐related folding in the seismic zone. The estimated preferred faulting model suggests that a higher dip angle fault (maximum slip of ∼1.1 m), and an overlying gentle dipping fault (maximum slip of ∼1.2 m) within the Bandar‐e‐Lengeh Anticline, are responsible for the first and second main shocks, respectively. The calculated Coulomb failure stress change suggests that the first main shock and its Mw 5.7 aftershock have a significantly positive triggering effect in the second main shock. The accumulated interseismic strain should have been partly released by the two main shocks. Finally, the salt diapir activity may affect the generation of the earthquake in the seismic zone.