bluuebunny/crossref_metadata_2025_split huggingface dataset:
Incidence of Traumatic Optic Neuropathy Associated with Subtypes of Orbital Wall Fracture: A Systematic Review
Authors: Alshammari Abdulmohsen Jameel , AlRajhi Bassam , AlNojaidi Taif Fawaz , Alqam Rakan Abu , Madani Firas Mohamed , Alrajeh Mohammed 
Published: September 2023

Abstract

Background: Traumatic optic neuropathy (TON) is a rare condition with serious consequences. One common cause of TON is orbital wall fracture, which can occur at any site. This study aimed to report the incidence of TON in orbital wall fractures.
Materials and Methods: A systematic search of Medline, Scopus, and the Directory of Open Access Journals (DOAJ) was conducted. The following terms were used: (traumatic optic neuropathy OR blindness) AND (craniofacial trauma OR facial fractures OR fracture pattern OR orbital wall fracture OR Visual field orbital wall fractures) AND (Visual acuity OR Visual evoked potential) AND (Mega-dose steroid therapy OR corticosteroids). This review encompassed both Randomized Controlled Trials (RCTs) and observational investigations, comprising both prospective and retrospective studies.
Results: Four studies met our inclusion criteria with 2720 patients included in this study. Most of the patients were males (n = 2175, 80%). A total of 3791 orbital wall fracture subtypes were reported in the included patients. Of them, 1522 patients had multiple fractures. The highest incidence of fracture was floor fracture, with an Event Rate (ER) of 42.2%, followed by lateral fracture (ER = 37.9%), roof fracture (ER = 36.2%), and medial fracture with ER (29%). Motor vehicle accidents were the most common injury mechanism reported in 46 patients, compared with traumatic injuries reported in 23 patients.
Conclusion: Lateral and superior orbital wall fractures were the most common orbital fractures in patients with TON. Periorbital hematoma and subconjunctival hemorrhage were the most frequently reported complications. Hence, ophthalmologists treating patients with TON should prepare radiological assessments and consider the surrounding structures to prevent damage to other structures.
Pediatric ping-pong skull fractures treated with vacuum-assisted elevation
Authors: Ahmed Syed D. , Allhusen Virginia D. , Muhonen Michael G. , Magge Suresh N 
Published: September 2023

Abstract
Purpose
Depressed (“ping-pong”) skull fractures can be treated by different means and the outcomes for children treated with vacuum-assisted elevation are comparable to surgical treatment.
Methods
We present a retrospective review of all ping-pong skull fractures treated with vacuum-assisted elevation at Children’s Hospital of Orange County in 2021-22. Variables included patient age, mechanism of injury, fracture depth, bone thickness at fracture site, and degree of elevation.
Results
Seven patients underwent vacuum-assisted elevation of ping-pong fractures bedside without the use of anesthesia. Fractures caused by birth-related trauma were deeper than those caused by falls (p < .001). There was no difference between groups in bone thickness at the fracture site (2.10mm vs 2.16mm, n.s). Six of the seven patients experienced significant improvement in fracture site depression, with four displaying a complete fracture reduction and two displaying significant reduction. Degree of fracture reduction was modestly related to depth of fracture, with the two deepest fractures failing to achieve full reduction. Age appeared to be related to fracture reduction, with the lowest reduction observed in one of the oldest patients in this sample. No complications were observed in any patient other than temporary mild swelling at the suction site, and no re-treatment or surgery for the fractures was required.
Conclusion
Vacuum-assisted elevation of ping-pong skull fractures is a safe and effective treatment option for infants under certain circumstances and has many benefits. The procedure can be safely done at the bedside, avoids the need for open surgical intervention, anesthesia, or hospital admission, and is a relatively quick procedure.
Tyrosinase-based proximity labeling in living cells and in vivo
Authors: Hamachi Itaru , Zhu Hao , Oh Jae Hoon , Matsuda Yuna , Mino Takeharu , Ishikawa Mamoru , Nakamura Hideki , Tsujikawa Muneo , Nonaka Hiroshi 
Published: September 2023

Abstract
Proximity labeling (PL) has emerged as a promising technology for spatial proteomics. However, most enzymes adopted for PL still have poor biocompatibility in vivo or suffer from slow or high-background labeling. We introduce a bacterial tyrosinase, BmTyr, as a new PL enzyme that addresses these limitations. BmTyr can be genetically fused or ligand-guided to a protein-of-interest in living cells and in vivo, unveiling its surrounding proteome efficiently by PL-based proteomics.
Identification of Neuropathogenic Equid Herpesvirus 1 as a Potential Cause of Respiratory Disease Outbreaks among Horses in North Xinjiang, China, from 2021-2023
Authors: Tong Panpan , Yang Enhui , Liu Bin , tian Shuyao , Suo Youtu , Pan JuanJuan , Dang Yueyi , Palidan Nuerlan , Jia Chenyang , Kuang Ling , Xie Jinxin 
Published: September 2023

Abstract
Background: Equid herpesvirus 1 (EHV-1) is among the most important viruses responsible for respiratory disease outbreaks among horses throughout the world. No reports to date have detailed the association between EHV-1 and respiratory disease among horses in China. This study described one such outbreak among a population of horses in north Xinjiang that occurred from April 2021 - May 2023.
Results: qPCR revealed that EHV-1 was detectable in all samples and this virus was identified as a possible source of respiratory disease, although a limited subset of these samples were also positive for EHV-2, EHV-4, and EHV-5. In total, three EHV-1 strains responsible for causing respiratory illness in horses were isolated successfully, and full-length ORF33 sequence comparisons and phylogenetic analyses indicated that these isolates may have originated from EHV-1 strains detected in Yili horse abortions. ORF30 sequence data additionally suggested that these strains were neuropathic, as evidenced by the presence of a guanine residue at nucleotide position 2254 corresponding to the aspartic acid present at position 752 in the DNA polymerase encoded by this virus.
Conclusion: This study is the first report of an outbreak of respiratory disease among horses in China caused by EHV-1. ORF30 sequence characterization revealed that these EHV-1 strains harbored a neuropathogenic genotype. Given the detection of this virus in both aborted equine fetuses and in horses suffering from respiratory disease, concern is warranted with respect to this neuropathogenic EHV-1 outbreak.
Diverse Characteristics of Users for Personalized Sequential Recommendation
Authors: Hu Jiahao , Zhao Fen , Chen Ruizhen 
Published: September 2023

Abstract
The dynamic sequence is a core feature in many modern recommendation systems. Transformer models have achieved significant success in machine translation, inspiring some researchers to introduce self-attention mechanisms into the sequential recommendation, yielding satisfactory results. However, these models share a common issue in that they lack consideration of the user's information, making it impossible to perform multi-level modeling of users accurately. Essentially, they are non-personalized models. To address the above challenges, this study proposes an approach called DCUPSRec (a personalized sequential recommendation model based on the diverse characteristics of users). This method establishes relationships between users and items in their historical interaction data and, within the sequential framework, models complex relationships between users based on their diverse characteristics and the impact of these relationships on recommended items. In addition, we use Stochastic Shared Embeddings (SSE) regularisation techniques to address potential overfitting problems caused by the introduction of users' diverse features. Extensive experiments using various users' features demonstrate that our approach transcends other sequential models when dealing with sparse and dense datasets and a variety of evaluation metrics.
Competition explains tropical tree species coexistence and abundance
Authors: Kohyama Takashi S. , Shigesada Nanako , Kawasaki Kokichi , Potts Matthew D. , Hajar Zamah S. Nur , Kohyama Tetsuo I. , Sheil Douglas 
Published: September 2023

Abstract
The numerous tree species co-occurring in tropical forests presents a challenging puzzle1. Conventional competition models suggest that such coexistence is improbable2–7, but this study offers a novel solution. By modelling interspecific competition as both competitive intensity and susceptibility, we provide conditions for stable coexistence of multiple species8. We test how well our model captures the aboveground biomass dynamics of a Malaysian rainforest tree community. We use estimated leaf biomass per species as a proxy for competitive intensity and derive model parameters from repeated measurements. Our model predicts that 370 out of the 486 tree species assessed coexist stably. This coexistence hinges on that the species’ susceptibility to conspecific competitive intensity, which we refer to as the conspecific negative biomass dependence (CNBD), is greater than their susceptibility to heterospecific competitive intensity. The modelled equilibrium biomass of the forest, and that of most species, align closely with empirical observations, suggesting the reliability of our approximations. Notably, strong CNBD corresponds to the decline of relative tree growth rates as tree size increases. Our study provides an unexpectedly simple and coherent explanation for the stable coexistence of numerous tree species, resolves the long-standing diversity-stability paradox, and challenges previous interpretations of competitive coexistence.
Phenotypic characterisation and comparative non-targeted GC-MS-based metabolomic profiling of two contrasting seedling fonio millet (Digitaria exilis) accessions: an insight to drought tolerance in small millets
Authors: Animasaun David Adedayo , Lawrence Judith Amaka 
Published: September 2023

Abstract

Fonio millet is an orphan crop with great economic and food security potential. However, drought negatively affects its production and yield in semi-arid and arid regions. This study compared the growth and metabolomic profiles of two contrasting fonio accessions (NGB02089 and NGB02082) in response to water stress at the seedling stage. The results showed variation in the morph-agronomic characters of the accessions. There were also significant (p < 0.05) positive correlations in the traits studied which means that the traits can be improved simultaneously. Chlorophyll content increased progressively with weeks after sowing (WAS) but decreased when seedlings were exposed to water stress. Biomass yield of NGB02082 was higher than that of NGB02089 although the latter grew more vigorously. However, NGB02089 had longer roots. The GC-MS analysis identified 12 significant metabolites that differed in composition between the fonio accessions, including sugars, fatty acids and siloxanes. The amount of siloxane decreased in NGB02082 with increasing drought duration increased but increased in NGB02089. Similarly, cis-13-octadecenoic acid was present in NGB02082 at 4 WAS but absent at 5 WAS, whereas NGB02089 produced more metabolites. Similarly, phthalimide, triacontane, vaccenic acids, and cholestane were produced in response to drought stress duration. The results of this study showed that NGB02089 and NGB02082 have different metabolomic responses to drought, which confers resistance to NGB02089 while NGB0282 is drought susceptible. The result of this study suggests that metabolic responses to drought may be useful in developing varieties with a better tolerance or adaptation to drought conditions.
The Impact of Cognition-affecting Neurological Diseases on Reaction Time and Driving Speed Deviation
Authors: Diamanti Athina , Ziakopoulos Apostolos , Yannis George 
Published: September 2023

Background:
Globally, more than 322 million people are living with depression, with a considerable percentage driving while under the effects of such impairments. Their impacts on specific parameters of driver behavior and road safety, such as driver speed and reaction time, however, remain understudied. The literature indicates that driving performance deteriorates in patients with depressive symptoms, causing increased crash probability and more aggressive behavior.

Objective:
The objective of this research was to examine the influence of neurological diseases on driving performance, and particularly, how depression affects reaction time and the standard deviation of driving speed.

Methods:
Data were obtained from a large-scale simulator study comprising 12 driving urban and rural trials. The sample consisted of 113 impaired participants, suffering from mild cognitive impairment, Parkinson’s disease, Alzheimer’s disease, and depression, and 92 people with no cognitive impairments as the control group. Inclusion criteria comprised having a driving license and driving experience (≥3 years), being active drivers, not having critical psychosis, eye or motor disorders, and not having drug/alcohol addictions.

Results:
Analysis of cognitive impairments based on GDS questions showed that frequent ‘feelings of boredom’ correlated with a 7% increase in reaction time and a 8% increase in the standard deviation of driving speed. Conversely, ‘feelings of worthlessness’ reduced the standard deviation of driving speed by 4.5%. ‘Feeling full of energy’ contributed marginally significant increases to reaction times of 4%. Drivers with Alzheimer’s and Parkinson’s diseases showed higher reaction times, while drivers with depression and the control group showed lower reaction times. Drivers with Parkinson’s disease showed statistically fewer deviations of average speed.

Conclusion:
This research shows that cognitively impaired individuals have larger reaction times and more erratic driving speeds. Present findings can be used to inform both patients and authorities of their driving behavior and can be considered when (re)issuing driving licenses.
Dose Escalation by Intraluminal Brachytherapy in Cancer Esophagus – A Retrospective Audit
Authors: Gupta Richa , Kumar Piyush , Mehta Ankita , Garg Ayush , Agarwal Shubhi 
Published: September 2023

Introduction- Chemoradiation (CRT) in esophageal cancer as a definitive modality of treatment has shown an increasing trend of utilization over surgical modalities. Local failures after chemoradiotherapy have led to the concept of radiation dose escalation, but simultaneously it leads to the concerns of radiation related toxicities of strictures and fistulas. Considering this fact dose escalation with intraluminal brachytherapy seems and optimal option. The present study retrospectively analyzed the safety and efficacy of using ILBT as a boost after external beam radiotherapy.Materials and Methods- Records of patients with Esophageal Carcinoma (EC) registered in the radiotherapy department between December 2008 to June 2016 were retrospectivelyanalyzed. Data was collected on patient, tumor and treatment characteristics and patient outcomes. The toxicitieshematological or radiation-induced were documented. Theresponse assessment after treatment and survival parameters were analyzed. Univariate and multivariate analyses were done for survival parameters. Statistical significance was considered if p-value was less than 0.05.Results- A total of 69 patients were eligible for the present analysis. Male to female ratio 1.09:1, with median age of 60 years. The common primary side was the middle 1/3rd esophagus. The mean tumor length was 6.4cm and all patients had squamous cell carcinoma. EBRT dose of 59.4 Gy was received 94.2% of patients, 13 (18.8%) received ILRT radiotherapy with 6Gy in a single setting. The median concurrent chemotherapy administered were 5. Grade 3 and 4 acute hematological toxicities were seen in terms of anemia (7.2%), leucopenia (18.8%) and thrombocytopenia (1.4%). Stenosis was seen in 40.6% of patients among which only 13 patients required dilatation. Nine of the patients receiving intraluminal brachytherapy (ILBT) developed fistula. The compete response was better in ILBT group (84.61 vs 57.49%, p=0.07). The median overall survival for all patients was 15 months. Overall survival was increased in patients of ILBT group (41 months versus 12 months, p=0.005).Conclusion- ILBT has the advantage of high precision and avoidance of dose to critical structures which could be optimally used for dose escalation in patients of cancer esophagus.
Education in Laparoscopic Cholecystectomy: Design and Feasibility Study of the LapBot Safe Chole Mobile Game (Preprint)
Authors: Noroozi Mohammad , St John Ace , Masino Caterina , Laplante Simon , Hunter Jaryd , Brudno Michael , Madani Amin , Kersten-Oertel Marta 
Published: September 2023

BACKGROUND

Major bile duct injuries during laparoscopic cholecystectomy (LC), often stemming from errors in surgical judgment and visual misperception of critical anatomy, significantly impact morbidity, mortality, disability, and health care costs.

OBJECTIVE

To enhance safe LC learning, we developed an educational mobile game, LapBot Safe Chole, which uses an artificial intelligence (AI) model to provide real-time coaching and feedback, improving intraoperative decision-making.

METHODS

LapBot Safe Chole offers a free, accessible simulated learning experience with real-time AI feedback. Players engage with intraoperative LC scenarios (short video clips) and identify ideal dissection zones. After the response, users receive an accuracy score from a validated AI algorithm. The game consists of 5 levels of increasing difficulty based on the Parkland grading scale for cholecystitis.

RESULTS

Beta testing (n=29) showed score improvements with each round, with attendings and senior trainees achieving top scores faster than junior residents. Learning curves and progression distinguished candidates, with a significant association between user level and scores (<i>P</i>=.003). Players found LapBot enjoyable and educational.

CONCLUSIONS

LapBot Safe Chole effectively integrates safe LC principles into a fun, accessible, and educational game using AI-generated feedback. Initial beta testing supports the validity of the assessment scores and suggests high adoption and engagement potential among surgical trainees.
Analisis Kelemahan APIP Inspektorat dalam Mengimplementasikan Probity Audit pada Pengadaan Barang dan Jasa Pemerintah Kabupaten Musi Banyuasin
Authors: Septiani Hafidzah , Nurhayati Ratna 
Published: September 2023

Penelitian ini bertujuan untuk mengevaluasi bagaimana APIP Inspektorat Kabupaten Musi Banyuasin mengimplementasikan probity audit pada PBJ pemerintah. Selain itu, penelitian juga menganalisis faktor-faktor yang menjadi kelemahan APIP Inspektorat Kabupaten Musi Banyuasin dalam mengimplementasikan probity auditpada PBJ.Pendekatan kualitatif dengan studi kasus digunakan dalam penelitian ini. Teknik pengumpulan data yang digunakan adalah wawancara mendalam dengan jenis wawancara semiterstruktur dan dokumen yang berkaitan dengan penelitian. Partisipan terdiri atas enam orang yaitu Inspektur Pembantu Bidang Pembangunan, Ketua Tim probity audit dan dua orang anggota probity audit, Kuasa Pengguna Anggaran, dan Pejabat Pelaksana Teknis Kegiatan.Hasil penelitian menunjukkan bahwa implementasi probity audit yang dilaksanakan oleh Inspektorat Kabupaten Musi Banyuasin belum optimal karena hanya berdasarkan surat permintaan dari perangkat daerah, surat pernyataan probity audit dan surat manajemen representasi tidak dilakukan, melaksanakan probity audit untuk memenuhi MCP KPK, serta tidak dilakukan secara real time dan hanya dilaksanakan pada tahap pelaksanaan kontrak. Selain itu, terdapat faktor-faktor kelemahan APIP dalam implementasi probity audit yaitu pada tahap perencanaan PKPT tidak dijadikan sebagai mandat, tidak ada kebijakan probity audit, dan pada tahap pelaksanaan, yaitu keterbatasan waktu pelaksanaan, pemenuhan dokumen, dan kompetensi auditor.
History of unmanned aircraft flight controller development
Authors: Tsench Yu. S. , Kurbanov R. K. 
Published: September 2023

Unmanned aircraft ﬁnd successful applications across various ﬁelds and continue to see increasing demand in numerous sectors. Modern ﬂight control systems empower the creation and programming of unmanned vehicles for a diverse range of tasks.(Research purpose) This study aims to retrospectively analyze the evolution of drone control systems, tracing their development from the early unmanned aerial vehicles to the ﬂight controllers of modern multifunctional drones. (Materials and methods) The study employs the historical-analytical method for data collection and processing. This encompasses a thorough examination of original works by both domestic and foreign authors, including literary references, scientiﬁc journal articles, monographs, conference materials, museum exhibitions, photographic archives, and open-access software source code. (Results and discussion) The historical process of unmanned aerial vehicle development has led to the emergence of many types of designs that provide better ﬂight performance and new functions through the creation of ﬂight control systems. Designers integrated worldwide aviation expertise and the latest advancements in science, engineering, and technology to enhance unmanned systems. The miniaturization of ﬂight control systems has facilitated the widespread adoption and application of unmanned aerial vehicle in many domains. The introduction of intelligent ﬂight control modes has ensured a high level of autonomy in drone operations. (Conclusions) In the course of the research into the historical development of control systems for unmanned aerial vehicles, block diagrams illustrating these control systems were created. Additionally, a block diagram was constructed outlining the evolution of these systems, with a periodization of individual stages. The block diagram includes nine stages; with the current emphasis primarily directed towards the advancement of intelligent control systems. The ﬁndings conﬁrm that the extensive diversiﬁcation of unmanned aerial vehicle applications and functionalities is closely linked to the continuous development and enhancement of micro-electromechanical systems technologies. The study identiﬁes the key ﬂight controllers that have signiﬁcantly inﬂuenced the enhancement of unmanned aircraft and have outlined potential directions for the future development of ﬂight controllers.