bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development and validation of Tool for Assessment of post vaccination confidence in COVID 19 Vaccines
Authors: Abuyadek Rowan , Hafeez Samar Samy Abdel , Tahoun Mohamed Mostafa , Othman Sally Samir , Omran Abdelrahman Hussein , Youssef Naglaa Fathy , Ghazy Ramy Mohamed 
Published: August 2023

Abstract

Background: Vaccine confidence is defined as the belief that vaccines work, are safe and are part of a trustworthy medical system. The objective of this study was to develop and validate a tool to assess confidence in effectiveness of the received coronavirus diseases 2019 (COVID-19 vaccines).
Methods: The research team developed a vaccine confidence tool based on the three domains defined by the Centers of disease Control and prevention (CDC), and the tool was translated into Arabic. Data from 406 eligible vaccinated adults (≥18 years) were included in the analysis. Internal consistency was assessed by Cronbach's alpha, and construct validity was determined by concurrent, convergent, discriminant, exploratory, and confirmatory factor analyses.
Results: Among the 406-adult population, ages ranged from 18 to 77 years. 63.1% were males, 56.7% were married, 21.9% had chronic diseases, 93.3% were non-smokers, and 39.6% were obliged to receive vaccination. The three domains of the scale met the criterion of internal consistency (Cronbach's alpha ≥ 0.7). Convergent validity was identified by the significant inter-item and item-mean score of the sub-scale correlation (P<0.001). Discriminant validity was reported as the inter-factor correlation matrix (<0.7). The Kaiser-Meyer-Olkin sampling adequacy measure was 0.80, and Bartlett's sphericity test was highly significant (P<0.001). Exploratory factor analysis indicated that the scale could be summarized into three factors. Confirmatory factor analysis confirmed the adequate psychometric properties and fit with observed data (RMSEA = 0.08, CFI = 0.945, TLI = 0.924, SRMR = 0.086, NFI = 0.918, and GFI = 0.909).
Conclusion: The vaccine confidence tool developed in this study is valid and reliable for assessing confidence in vaccine effectiveness, safety, and confidence in the healthcare system.
Intelligent Visual Technique for an Assessment of Tweet Data Towards Social-Recommended Healthcare Solutions
Authors: Narasimulu K , Prasad K Rajendra , Satheesh S , Nuvvusetty Rajasekhar , Srini J 
Published: August 2023

Abstract
Twitter has grown to be a vital social media platform for sharing healthcare knowledge, with over 300 million monthly active users. This paper addresses healthcare social recommendations using health tweets on social networks. Twitter's health-related tweet categorization is mainly dependent on topic models, which, unlike TF-IDF) (referred to as term frequency and inverse document frequency), discover topics (or health clusters) inside unlabeled tweets. Traditional topic models are used to extract the characteristics of tweets and model those characteristics. Visual assessment of clustering tendency (VAT) and cosine-based VAT (cVAT) are two state-of-the-art visual techniques for analyzing health data clusters of tweets. In the proposed work, intelligent multiple perspective cosine similarity-based VAT (IMPCS-VAT) is developed, which has achieved remarkable success in finding health clusters regarding health issues and solutions using social health data. It considers multiple perspectives while calculating similarities while assessing the health tweets for the social recommended healthcare solutions. Reliable findings from clustering health tweets require multiple perspectives to access more useful similarity features across tweet documents. The experimental study is well illustrated with visual health clusters by the proposed visual technique to determine health tweets' topics in an intelligent mechanism.
Are floating toes associated with lifestyle in children: A cross-sectional study
Authors: Nagamoto Hideaki , Okunuki Takumi , Takahashi Shimpei , Wakamiya Kazuki , Liu Zijian , Maemichi Toshihiro , Katsutani Hirofumi , Yamada Yoshiyasu , Takahashi Hiroyuki , Tanaka Hirofumi , Aizawa Toshimi , Kumai Tsukasa 
Published: August 2023

Abstract
Background:
Floating toes are a condition and deformity in which some of the toes are afloat. Many functional impairments in floating toes have been previously studied lately and several factors related to floating toes have also been reported. However, no reports have considered the relationship between lifestyle and floating toes among children. The purpose of this study was to reveal the prevalence of floating toes among school children and reveal its relationship with lifestyle.
Methods:
In total, 138 young male baseball players were recruited. Lifestyle was evaluated by using a questionnaire and chosen whether the main lifestyle was Japanese or Western, if the bedding was futons or beds, and if the toilet was Japanese style (a squat toilet) or Western style. Floating toes were defined as toes that were not in contact with the mat. Ankle dorsiflexion in the knee-flexed and knee-extended positions was measured in a weight-bearing position. The relationship between the floating toes and lifestyles, and the comparison of ankle dorsiflexion range of motion between the lifestyles were statistically analyzed.
Results:
Players living in a Western style showed a significantly higher prevalence of floating toes on both feet compared with the players living in a Japanese style (throwing side; 39% vs. 19%, p = 0.04, and non-throwing side; 43% vs. 19%, p = 0.01). Players living in a Western style with beds showed a significantly smaller range of motion on both sides of ankle dorsiflexion in the knee-flexed position compared with those who were not (throwing side; 37.2 ± 5.7° vs. 39.0 ± 6.6°, p = 0.04, and non-throwing side; 36.8 ± 5.8° vs. 38.6 ± 6.1°, p = 0.04).
Conclusion:
Children mainly living in a Western lifestyle showed a significantly higher prevalence of floating toes on both feet compared to those mainly living in a Japanese lifestyle. The prevalence of floating toes may be related to lifestyles among children.
Trial Registration:
The study was approved by the institutional review board of the Waseda University Graduate School of Sport Sciences (IRB number 2021 − 185).
AI-2 quorum sensing system contributes fluoroquinolones resistance of Salmonella typhimurium by regulating metabolism
Authors: Gao Shuji , Quan Yingying , Jin Wenjie , Shen Yamin , Yuan Shuo , Wang Yuxin , Tian Mingming , Qi Jingjing , Bao Yanqing , Wang Shaohui , Wang Yang 
Published: August 2023

Abstract
The multidrug-resistant Salmonella is becoming major health threat due to inappropriate use of antibiotics. It is found that the metabolic changes contributed to bacterial drug resistance. AI-2 quorum sensing (QS) is involved in the regulation of bacterial metabolic activities. However, the role of AI-2 quorum sensing in the metabolic activities and drug resistance of Salmonella remain unclear. In this study, we determined the drug sensitivity of Salmonella typhimurium by 96-well plate and then determined the time-killing curve. Then, the regulation of AI-2 quorum sensing on Salmonella metabolic activity was analyzed by quantitative real‑time PCR and LC-MS metabonomics. The results showed that luxS mutant strain of Salmonella typhimurium lacking AI-2 quorum sensing was at least 4-fold less sensitive to killing by fluoroquinolone antibiotics. The decreased cell killing after the fluoroquinolones challenge was found to involve a low metabolic state presented by up-regulating anaerobic respiration, and LC-MS metabonomics analysis showed that the low metabolic state of luxS deletion strain might be related to the metabolism of amino acids such as leucine and valine. In conclusion, this study indicated that the deletion of luxS gene in Salmonella typhimurium mediated the tolerance to fluoroquinolones by affecting valine metabolism and up-regulating the anaerobic metabolism pathway.
Genetic Analysis of Fusarium Wilt Resistance in Upland Cotton Germplasm (Gossypium hirsutum L.)
Authors: Khusenov Naim N. , Norbekov Jurabek K. , Boykobilov Umid A. , Yuldosheva Zebo S. , Makamov Abdusalom Kh. , Ayubov Mirzakamol S. , Darmanov Mukhtor M. , Asrorov Akmal M. , Buriev Zabardast T. , Turaev Ozod S. , Yu John Z. , Kushanov Fakhriddin N. 
Published: August 2023

Abstract
The causative agent of fusarium wilt (FW) disease, Fusarium oxysporum f. sp. vasinfectum (FOV) pathogen, is one of the economically serious soil fungi that cause significant damage to cotton crops worldwide. For several years, this pathogen has been detrimentally affecting cotton production in many countries including Uzbekistan and the United States. The damage is often resulted from drying up and the death of cotton seedlings. In this study, we evaluated the resistance of cotton (Gossypium hirsutum L.) lines, obtained from the Uzbekistan cotton germplasm collection, against FOV race 4 by infecting them with the pathogen four times during two years in a phytotron condition. Several cotton lines showed high resistance to FW diseases, such as Rex, PD-648, Mebane B-1, Las Brenas-347, and DPZ-554085. The screening was conducted with a total of 118 simple sequence repeat (SSR) markers known to be associated with FW resistance to determine the genetic polymorphisms between resistant and susceptible cotton accessions. A total of 40 markers were polymorphic and produced 165 alleles, with an average of 4.125 alleles per locus. The FW-resistant cotton lines with resistance marker alleles would be useful sources for marker-assisted selection (MAS) approaches to developing wilt-resistant cotton cultivars with superior fiber yield and quality.
Effects of the core heading date genes Hd1, Ghd7, DTH8, and PRR37 on yield-related traits in rice
Authors: Guo Jingxin , Sun Kangli , Zong Wubei , Xiao Dongdong , Wu Zeqiang , Li Fuquan , Guo Xiaotong , Li Weitao , Lin Zhiwei , Xie Wenhao , Li Shengting , Hao Yu , Song Yingang , Xu Bingqun , Wei Guangliang , Liu Yao-Guang 
Published: August 2023

Abstract
Heading date is a key agronomic trait in rice (Oryza sativaL.) that determines yield and adaptability to different latitudes. Heading date 1 (Hd1), Grain number, plant height, and heading date 7 (Ghd7), Days to heading on chromosome 8 (DTH8), and PSEUDO-RESPONSE REGULATOR 37 (PRR37) are core rice genes controlling photoperiod sensitivity, and these genes have many haplotypes in rice cultivars. However, the effects of different haplotypes at these genes on yield-related traits in diverse rice materials remain poorly characterized. In this study, we knocked out Hd1, Ghd7, DTH8, or PRR37, alone or together, in indica and japonica varieties and systematically investigated the agronomic traits of each knockout line. Ghd7and PRR37 increased the number of spikelets and improved yield, and this effect was enhanced with the Ghd7 DTH8 or Ghd7 PRR37 combination, but Hd1 negatively affected yield. We also identified a new weakly functional Ghd7 allele containing a mutation that interferes with splicing. Furthermore, we determined that the promotion or inhibition of heading date by different PRR37haplotypes is related to PRR37 expression levels, day length, and the genetic background. For rice breeding, a combination of functional alleles of Ghd7 and DTH8 or Ghd7 and PRR37 in the hd1 background can be used to increase yield. Our study clarifies the effects of heading date genes on yield-related traits and the functional differences among their different haplotypes, providing valuable information to identify and exploit elite haplotypes for heading date genes to breed high-yielding rice varieties.
Application of a subcritical water extraction technique for enhancing extraction of bioactive compounds from propolis
Authors: Shin Su-Bin , Lee Jin-Kyoung , Ko Min-Jung 
Published: August 2023

Abstract
The bioactive compounds and antioxidant activities of propolis extracts were investigated using subcritical water extraction (SWE). SWE was performed by varying 1extraction temperature (110–200°C) and time (10–30 min). SWE using only water as the solvent successfully to extracted bioactive compounds from propolis using high-purity glass thimbles. The concentrations of galangin (16.37 ± 0.61 mg/g), and chrysin (7.66 ± 0.64 mg/g) from propolis were maximal at 200°C for 20 min, and 170°C for 20 min, respectively. The maximum yields of the total phenolics (226.37 ± 4.37 mg/g), flavonoids (70.28 ± 1.33 mg/g), and antioxidant activities (88.73 ± 0.58%, 98.86 ± 0.69%, and 858.89 ± 11.48 mg/g) were obtained at 200°C for 20 min. Compared with using conventional ethanol extraction (at 25°C for 24 h), all yields of SWE extracts obtained at 200°C for 20 min were higher. These results indicated that SWE is a much faster and more efficient method for extracting bioactive compounds from propolis.
Primordial odontogenic tumor – Report of two cases and review of current concepts
Authors: Cavalcante Israel Leal , Barros Caio César da Silva , Cruz Vitória Maria Sousa , Costa Mariana Bispo , Santos Daniel Facó da Silveira , de León-Garza Bernardo , Parra-Salazar Marco Antonio , Turatti Eveline , Cruz-Tapia Roberto Onner , Cavalcante Roberta Barroso , de Andrade Bruno Augusto Benevenuto 
Published: August 2023

Abstract
Primordial odontogenic tumor (POT) is a rare mixed odontogenic tumor composed of mesenchymal cells, columnar odontogenic epithelium, and fibromyxoid stroma affecting the posterior mandible of children and adolescents. Herein, we report two cases of POT and the clinicopathological features of previous cases reported in the literature. A 12-year-old and 19-year-old female patient presented an asymptomatic swelling in the posterior maxilla and posterior mandible, respectively. Imaging exams revealed radiolucent lesions associated with uneruptedteeth. The lesions were surgically removed, and the histopathological examination revealed spindle-to-ovoid mesenchymal cells in a fibromyxoid stroma surfaced by columnar odontogenic epithelial cells with reverse nuclear polarization. Deposition of mineralized tissue was observed. The final diagnosis was POT, and patients do not exhibit recurrence signs. POT should be included in the differential diagnoses of intraosseous lesions in the posterior mandible in pediatric patients.
Abundance and biting habits of anopheline mosquitoes, and malaria incidence in Rwandan lowlands: analysis of 9 years data from two entomological surveillance sentinel sites
Authors: MANISHIMWE Alexis , Hakizimana Emmanuel , Ndagijimana Albert 
Published: August 2023

Abstract
Background
Studies have explored sociodemographic factors that drive malaria morbidity in Rwanda. Little is known about the contribution of entomology in the transmission of malaria in the endemic lowlands of Rwanda. This study aimed to assess the composition, and behavior of anopheles species, and the dynamics of malaria transmission in Eastern Province, Rwanda.
Methods
This cross-sectional study used data captured by the national entomological surveillance system from January 2012 to December 2020. Mosquitoes were collected twice monthly in three different villages at each sentinel site, using Human Landing Catches (HLC) method. This data together with monthly malaria incidence was used for the descriptive analyses.
Results
Anopheles gambiae species was the most abundant at Rukara (72.92%), and Mimuri (99.23%) sentinel sites. Rukara recorded 15 different anopheline species, while the Mimuri site recorded only 2 species. The vector abundance has decreased tremendously over the study period, but malaria incidence remains high in the Rukara sentinel site, where anopheline species are unevenly distributed, while the incidence has significantly reduced at the Mimuri site. An. Gambiae spp, the most abundant anopheline species were exophagic (mean endophagic index < 0.5), and their mean human biting rates were 18.5 ± 20.52 and 65.7 ± 94.83 bites/ person/ night at Rukara and Mimuri, respectively.
Conclusion
These results highlight that an. gambiae complex anophelines are the most important malaria vectors in Eastern Province, and they predominantly bite outdoors. These findings also help us understand why indoor malaria interventions alone will not control malaria. Therefore, interventions that target outdoor mosquito density and bites are recommended.
Earlier peak photosynthesis timing accelerates wildfire outbreak and expands burned area
Authors: Wu Chaoyang , Lai Genke , Li Jialing , Wang Jun , Zhang Yongguang , Zohner Constantin , Penuelas Josep 
Published: August 2023

Abstract
The frequency and intensity of wildfires in recent decades have reached unprecedented levels1-3, raising questions about the role of vegetation phenology in driving these changes. By examining both terrestrial fire perimeters and satellite observations, we found that an earlier peak photosynthesis timing (PPT) contributes to the acceleration of wildfire outbreaks and the expansion of burned areas across the Northern Hemisphere. This correlation can be attributed to intensified drought conditions and an increased leaf supply resulting from earlier senescence. We further show that current fire-vegetation models are capable of reproducing the negative correlation between PPT and burned area, but they significantly underestimate the strength of this relationship. Our findings provide valuable insights for enhancing early wildfire detection and prediction methods by considering the feedback effects of vegetation on fire risk.
The potential impact of exercise upon symptom burden in adolescents and young adults undergoing cancer treatment
Authors: Munsie Claire , Ebert Jay , Joske David , Collins Jo , Ackland Timothy 
Published: August 2023

Abstract
Purpose
Adolescents and young adults (AYAs) experience vast symptom burden resulting from cancer treatment-related toxicities (TRTs). Evidence supports integrated exercise to mitigate several TRTs in other cohorts, however evidence in AYAs is lacking. Conventional reporting of TRTs adopts a maximum grade approach failing to recognise the trajectory over time, of persistent, or lower grade toxicities. Alternatively, longitudinal analysis of toxicities over time (ToxT) may provide clinically meaningful summaries of this data. We evaluated the longitudinal impact of an exercise intervention on TRTs in AYAs undergoing cancer treatment.
Methods
A prospective, randomised trial allocated participants to a 10-week exercise intervention (EG) or control group (CG) undergoing usual care. Detailed information on TRTs was collected throughout the intervention. All TRTs were graded per the Common Terminology Criteria for Adverse Events (CTCAE v5.0).
Results
Forty-three (43) participants (63% male, mean age 21.1 years) were enrolled. When categorised to reflect the maximal worst grade experienced (Grade 0, Grade 1–2 and ≥ Grade 3), the CG reported an increased incidence of severe fatigue (≥ Grade 3) compared with the EG (p = 0.05). No other differences between groups were evident (p > 0.05). ToxT analysis of the four most common toxicities (fatigue, pain, nausea and mood disturbances) demonstrated no difference in the mean grade of each over time (p > 0.05).
Conclusion
A 10-week exercise intervention reduces the severity of fatigue in AYAs undergoing treatment. While the ToxT approach provided insight into the toxicity profile, adequately powered studies are needed to better understand these differences within a homogenous sample.
Trial registration (ACTRN12620000663954) 10th June 2020.
Diagnosis of Disease Affecting Gait with a Body Acceleration-Based Model Using Reflected Marker Data for Training and a Wearable Accelerometer for Implementation.
Authors: Alsaleem Fadi , Takallou Mohammad , Fallahtafti Farahnaz , Hassan Mahdi , Al-Ramini Ali , Qolomany Basheer , Pipinos Iraklis , Myers Sara 
Published: August 2023

Abstract
This paper demonstrates the value of a framework for processing data on body acceleration as a uniquely valuable tool for diagnosing diseases that affect gait early. As a case study, we used this model to identify individuals with peripheral artery disease (PAD) and distinguish them from those without PAD. The framework uses acceleration data extracted from anatomical reflective markers placed in different body locations to train the diagnostic models and a wearable accelerometer carried at the waist for validation. Reflective marker data have been used for decades in studies evaluating and monitoring human gait. They are widely available for many body parts but are obtained in specialized laboratories. On the other hand, wearable accelerometers enable diagnostics outside lab conditions.
Models trained by raw marker data at the sacrum achieve an accuracy of 92% in distinguishing PAD patients from non-PAD controls. This accuracy drops to 28% when data from a wearable accelerometer at the waist validate the model. This model was enhanced by using features extracted from the acceleration rather than the raw acceleration, with the marker model accuracy only dropping from 86% to 60% when validated by the wearable accelerometer data.
A non-invasive method to predict drought survival in Arabidopsis using quantum yield under light conditions
Authors: Rico-Cambron Thelma Y. , Bello-Bello Elohim , Herrera-Estrella Luis 
Published: August 2023

Abstract
Background: Survival rate is frequently used to compare drought tolerance among plant genotypes. However, determining the critical point for recovery irrigation has represented an issue that relies directly on a qualitative inspection by the researcher or on the employment of non-straightforward and invasive techniques that invalidate the subsequent use of the tested individuals.
Results: Here, we present a simple, instantaneous, and non-invasive method to estimate the survival probability of Arabidopsis thaliana plants after severe drought treatments. The quantum yield (QY) or efficiency of photosystem II was monitored in the last stage of the drought treatment, before recovery irrigation, in darkness (Fv/Fm) and light (Fv’/Fm’) conditions. We found a high correlation between a plant's Fv’/Fm’ value before recovery irrigation and its survival phenotype seven days after. This correlation was maintained in the Arabidopsis ecotypes Col-0, Ler-0, C24, and Kondara under the same conditions. Fv’/Fm’ was then applied as a survival predictor to compare drought tolerance of transgenic lines overexpressing the transcription factors ATAF1and PLATZ1 with the Col-0 control.
Conclusions: The results obtained in this work demonstrate that the chlorophyll a fluorescence parameter Fv’/Fm’ can be used as a survival predictor that gives a numerical estimate of the Arabidopsis drought survival rate before a recovery irrigation. The procedure employed to get the Fv’/Fm’ measurements is fast, non-destructive, and requires inexpensive and easy-to-handle equipment. Fv’/Fm’ as a survival predictor can be used to offer an overview of the photosynthetic state of the tested plants and determine the best timing for rewatering to assess the survival rate of tested lines more accurately, especially when the symptoms of severe dehydration between genotypes are not contrasting enough to identify a difference visually.