bluuebunny/crossref_metadata_2025_split huggingface dataset:
Repair using the pectoralis major musculocutaneous flap for refractory anastomotic leakage after total esophagectomy
Authors: Oga Yoko , Okumura Tomoyuki , Miwa Takeshi , Numata Yoshihisa , Matsumoto Shigeki , Kaneda Koji , Kimura Nana , Fukasawa Mina , Nagamori Masakazu , Mori Kosuke , Takeda Naoya , Yagi Kenta , Ito Miki , Nagaoka Yasuhiro , Takeshita Chitaru , Watanabe Toru , Hirano Katsuhisa , Igarashi Takamichi , Tanaka Haruyoshi , Hashimoto Isaya , Shibuya Kazuto , Hojo Shozo , Yoshioka Isaku , Abe Hideharu , Satake Toshihiko , Fujii Tsutomu 
Published: May 2023

Abstract
Background
The pectoralis major musculocutaneous flap (PMMF) is a pedicled flap often used as a reconstruction option in head and neck surgery, especially in cases with poor wound healing. However, applying PMMF after esophageal surgery is uncommon. We report here, the case of a successfully repaired refractory anastomotic fistula (RF) after total esophagectomy, by PMMF.

Case presentation
A 73-year-old man had a history of hypopharyngolaryngectomy, cervical esophagectomy, and reconstruction using a free jejunal graft for hypopharyngeal carcinosarcoma at the age of 54. He also received conservative treatment for pharyngo-jejunal anastomotic leakage (AL), then postoperative radiation therapy. This time, he was diagnosed with carcinosarcoma in the upper thoracic esophagus; cT3rN0M0, cStageII, according to the Japanese Classification of Esophageal Cancer 12th Edition. As a salvage surgery, thoracoscopic total resection of the esophageal remnant and reconstruction using gastric tube via posterior mediastinal route was performed. The distal side of the jejunal graft was cut and re-anastomosed with the top of the gastric tube. An AL was observed on the 6th postoperative day (POD), and after 2 months of conservative treatment was then diagnosed as RF. The 3/4 circumference of the anterior wall of the gastric tube was ruptured for 6 cm in length, and surgical repair using PMMF was performed on POD71. The edge of the defect was exposed and the PMMF (10 × 5 cm) fed by thoracoacromial vessels was prepared. Then, the skin of the flap and the wedge of the leakage were hand sutured via double layers with the skin of the flap facing the intestinal lumen. Although a minor AL was observed on POD19, it healed with conservative treatment. No complications, such as stenosis, reflux, re-leakage, were observed over 3 years of postoperative follow-up.

Conclusions
The PMMF is a useful option for repairing intractable AL after esophagectomy, especially in cases with large defect, as well as difficulties for microvascular anastomosis due to previous operation, radiation, or wound inflammation.
Impact of COVID-19 on quality of life in Peruvian older adults: construct validity, reliability and invariance of the COV19—Impact on Quality of Life (COV19-QoL) measurement
Authors: Caycho-Rodríguez Tomás , Carbajal-León Carlos , Vilca Lindsey W. , Reyes-Bossio Mario , Gallegos Miguel , Esteban Renzo Carranza , Noe-Grijalva Martin , Gallegos Walter L. Arias , Delgado-Campusano Mariel , Muñoz-del-Carpio-Toia Águeda 
Published: May 2023

AbstractThe aim of the present study was to translate into Spanish and evaluate the psychometric evidence of the Impact on Quality of Life (COV19-QoL) applied to a sample of Peruvian older adults (N = 298; 58.1% women, 41.9% men, mean age 65.34 years [SD = 11.33]). The study used techniques from the Classical Test Theory (CTT) and Item Response Theory (IRT). The findings confirmed the single factor structure of the COV19-QoL, high internal consistency reliability, measurement invariance by gender, and all items demonstrated adequate discrimination and difficulty indices. In this sense, the items allow adequate discrimination between low, medium and high levels of the impact of the COVID-19 pandemic on quality of life. In addition, a greater perceived impact of the pandemic on quality of life is necessary to answer the higher response options of the COV19-QoL. In conclusion, the COV19-QoL is a valid measurement scale of the impact of the COVID-19 pandemic on the quality of life of Peruvian older adults.
Network analysis of Iranian's health insurance ecosystem before and after the introduction of Universal Health Insurance law
Authors: Rahimisadegh Rohaneh , Noori Hekmat Somayeh , Mehrolhassani Mohammad Hossein , Jafari Sirizi Mohammad 
Published: May 2023

Abstract
Introduction
The policy-making process in health reform is challenging due to the complexity of organizations, overlapping roles, and diversity of responsibilities. The present study aims to investigate and analyze the network of actors in the Iran health insurance ecosystem regarding the laws before and after the adoption of the Universal Health Insurance (UHI).

Methods
The present study was done by sequential exploratory mixed method research, consisting of two distinct phases. During the qualitative phase, the actors and issues pertaining to the laws of the Iranian health insurance ecosystem from 1971 to 2021 were identified through a systematic search of the laws and regulations section of the Research Center of the Islamic Legislative Assembly website. Qualitative data was analyzed in three steps using directed content analysis. During the quantitative phase, in order to draw the communication network of the actors in Iran's health insurance ecosystem, the data related to the nodes and links of the networks was collected. The communication networks were drawn using Gephi software and the micro- and macro-indicators of network were calculated and analyzed.

Results
There were 245 laws and 510 articles identified in the field of health insurance in Iran from 1971 to 2021. Most of the legal comments were on financial matters and credit allocation, and the payment of premiums. The number of actors before and after the enactment of the UHI Law was 33 and 137, respectively. The Ministry of Health and Medical Education and the Iran Health Insurance Organization were found the two main actors in the network before and after the approval of this law.

Conclusions
Adopting a UHI Law and delegating various legal missions and tasks, often with support to the health insurance organization, have facilitated the achievement of the law objectives. However, it has created a poor governance system and a network of actors with low coherence. Based on the results of the study, it is suggested to reduce actor roles and separate them for better governance and to prevent corruption in health insurance ecosystem. Introducing knowledge and technology brokers can be effective in strengthening governance and filling the structural gaps between actors.
A brazilian nationwide multicenter study on deficiency of deaminase-2 (DADA2)
Authors: Melo Adriana , de Carvalho Luciana Martins , Ferriani Virginia Paes Leme , Cavalcanti André , Appenzeller Simone , Oliveira Valéria Rossato , Neto Herberto Chong , Rosário Nelson Augusto , de Oliveira Poswar Fabiano , Guimaraes Matheus Xavier , Kokron Cristina Maria , Maia Rayana Elias , Silva Guilherme Diogo , Keller Gabriel , Ferreira Mauricio Domingues , Vasconcelos Dewton Moraes , Toledo-Barros Myrthes Anna Maragna , Barros Samar Freschi , Neto Nilton Salles Rosa , Krieger Marta Helena , Kalil Jorge , Mendonça Leonardo Oliveira 
Published: May 2023

Abstract
Introduction
The deficiency of ADA2 (DADA2) is a rare autoinflammatory disease provoked by mutations in the ADA2 gene inherited in a recessive fashion. Up to this moment there is no consensus for the treatment of DADA2 and anti-TNF is the therapy of choice for chronic management whereas bone marrow transplantation is considered for refractory or severe phenotypes. Data from Brazil is scarce and this multicentric study reports 18 patients with DADA2 from Brazil.

Patients and methods
This is a multicentric study proposed by the Center for Rare and Immunological Disorders of the Hospital 9 de Julho - DASA, São Paulo - Brazil. Patients of any age with a confirmed diagnosis of DADA2 were eligible for this project and data on clinical, laboratory, genetics and treatment were collected.

Results
Eighteen patients from 10 different centers are reported here. All patients had disease onset at the pediatric age (median of 5 years) and most of them from the state of São Paulo. Vasculopathy with recurrent stroke was the most common phenotype but atypical phenotypes compatible with ALPS-like and Common Variable Immunodeficiency (CVID) was also found. All patients carried pathogenic mutations in the ADA2 gene. Acute management of vasculitis was not satisfactory with steroids in many patients and all those who used anti-TNF had favorable responses.

Conclusion
The low number of patients diagnosed with DADA2 in Brazil reinforces the need for disease awareness for this condition. Moreover, the absence of guidelines for diagnosis and management is also necessary (t).
Role of ultrasonographic measurement of the fetal epicardial fat pad and cardiac interventricular septal thickness in predicting the outcome and prevent various complications of gestational diabetes mellitus
Authors: Ghuman Gurnoor Kaur , Bagri Neha , Chandra Ranjan , Malik Amita , Misra Ritu , Gaikwad Harsha S. 
Published: May 2023

AbstractBackgroundGestational diabetes mellitus (GDM) is one of the most common medical conditions affecting pregnancy and increasing the risk for maternal and perinatal complications. The present study aimed at determining the role of ultrasonographic measurement of fetal epicardial fat pad thickness (f EFT) and fetal cardiac interventricular septal thickness (f IVST) at 24–32 weeks of gestation in the prediction of GDM.ResultsA prospective observational case–control study was conducted including a total of 35 GDM patients and 35 normal pregnancies who were subjected to ultrasonographic measurement of the f EFT and f IVST at 24–32 weeks of gestation. Statistical analysis and the receiver operating characteristic curves were used to find out the cutoff value, sensitivity, specificity and diagnostic accuracy of these two parameters for the prediction of GDM. When an f EFT value of 1.3 was accepted as a cutoff value, GDM could be predicted with a sensitivity of 68.6% and specificity of 91.4%, PPV of 88.9%, NPV of 74.4% and diagnostic accuracy of 80%. When an f IVST value of 2.6 was accepted as a cutoff value, GDM could be predicted with a sensitivity of 80%, specificity of 77.14%, PPV of 77.8%, NPV of 79.4% and diagnostic accuracy of 78.5%.ConclusionThe ultrasonographic measurements of fetal epicardial fat pad thickness and fetal cardiac interventricular septal thickness were statistically significantly higher in GDM pregnancies (pvalue < 0.0001) as compared to the controls. Thus, these two parameters can serve as excellent ultrasonographic markers in the prediction of GDM.
Emerging therapeutic potential of curcumin in the management of dermatological diseases: an extensive review of drug and pharmacological activities
Authors: Kumar Bhumika , Aggarwal Rohan , Prakash Udai , Sahoo Pravat Kumar 
Published: May 2023

Abstract
Background
Curcumin is a bright colored polyphenolic moiety which is derived from the rhizomes of Curcuma longa of family Zingiberaceae. Its simple molecular structure, high efficacy, variable therapeutic effects and multidimensional use make it ideal for various treatment regimens.

Main body
It has been used for centuries for its antioxidant, anti-inflammatory and antibacterial characteristics which makes it ideal in the determent and treatment of skin inflammation, psoriasis, acne, premature skin aging and skin cancers. It also exhibits antiviral, antiulcer, anticarcinogenic, antimutagenic, antibacterial, hypocholesteremia and antifungal, benefits making it a perfect multifunctional moiety for treating numerous disorders. Curcumin offers protection against skin damage induced by persistent UVB exposure. Curcumin has substantial therapeutic potentials against various skin conditions like anti-inflammatory, antioxidant effects, wound healing efficiency any many more. It illustrates a multiplicity of important medicinal properties which has a great potential in treating various dermatological diseases.

Conclusion
The study seeks to provide a comprehensive update on curcumin and its exceptional medicinal profile, which can be efficaciously and appropriately utilized in treating skin conditions like psoriasis, acne, dermatitis, scleroderma, skin cancers, skin aging, fungal infections and wounds.
Management of mucormycosis coexisting with aspergillosis in pediatric age group – a case report
Authors: Gopal Ashish , Singh Ishwar , Arora Nikhil , Patel Ditixaben J. , Jain Pooja Nakhat , Negi Sakshi , Mandal Shramana 
Published: May 2023

Abstract
Background
Mucormycosis is a highly infectious deadly disease if left untreated. This disease is usually seen more in people having immunocompromised conditions like diabetes mellitus, steroid use, and neutropenia. Its presence along with Aspergillus is quite uncommon in the pediatric age group. This report will add information regarding such coexisting fungal disease in the pediatric age group and its further management.

Case report
In this study, investigators are presenting a case of mucormycosis coexisting with aspergillosis in 3-month-old male child who presented with a palatal defect. He underwent both medical management with liposomal amphotericin B and surgical debridement for necrotic foci removal.

Conclusion
This case report deals with the management of coexisting mucormycosis with aspergillosis using a combination of surgical and medical management.
The need for environmentally realistic studies on the health effects of terrestrial microplastics
Authors: Mills C. Lauren , Savanagouder Joy , de Almeida Monteiro Melo Ferraz Marcia , Noonan Michael J. 
Published: May 2023

AbstractPlastic pollution is now so widespread that microplastics are regularly detected in biological samples surveyed for their presence. Despite their pervasiveness, very little is known about the effects of microplastics on the health of terrestrial vertebrates. While emerging studies are showing that microplastics represent a potentially serious threat to animal health, data have been limited to in vivo studies on laboratory rodents that were force fed plastics. The extent to which these studies are representative of the conditions that animals and humans might actually experience in the real world is largely unknown. Here, we review 114 papers from the peer-reviewed literature in order to understand how the concentrations and types of microplastics being administered to rodents in lab studies compare to those found in terrestrial soils. From 73 in vivo lab studies, and 41 soil studies, we found that lab studies have heretofore fed rodents microplastics at concentrations that were hundreds of thousands of times greater than they would be exposed to in nature. Furthermore, health effects have been studied for only 20% of the microplastic polymers that are known to occur in soils. Plastic pollution is arguably one of the most pressing ecological and public health issues of our time, yet existing lab-based research on the health effects of terrestrial microplastics does not reflect the conditions that free-ranging vertebrates are actually experiencing. Going forward, performing more true-to-life research will be of the utmost importance to fully understand the impacts of microplastics and maintain the public’s faith in the scientific process.
Graphical Abstract
Parameterize walkable urban forms considering perceptual qualities
Authors: Abdeldayem Walid S. , Morgan Sherif , Bakr Sawsan , Abdelhamid Ayman 
Published: May 2023

Abstract
Establishing new cities and communities to absorb the growth of the population is an urban regime for urban development; especially in developing countries like Egypt. Despite the massive construction done in new cities, people, as well as activities, are still attracted to traditional ones, where livability and walkability are well distinguished. That is all connected to what people perceive from the designed built environment. Much literature addresses this subjective relationship by specifying, measuring, and evaluating. Recent ones have correlated certain physical features and perceptual qualities related to walkability. This research aims to specify more this relationship by deducting design parameters that quantify perceptual walkable urban form. It measures 5 streets in 6 areas, which are already attracting walking and diverse activities in Greater Cairo. The research uses SPSS software to generate averages and ranges which represent values to describe certain urban form elements, the research concluded that different types of urban typologies endorse certain perceptual qualities more than others as well as present guiding design parameters for urban form elements that would help generate a well-perceived walkable urban form.
Log-constrained inversion based on a conjugate gradient-particle swarm optimization algorithm
Authors: Zou Guangui , Liu Yanhai , Teng Deliang , Gong Fei , She Jiasheng , Ren Ke , Han Chengyang 
Published: May 2023

Well-logging-constrained impedance inversion is an effective process for predicting the thickness and bifurcation of coal seams. Wavelet changes in a complex region achieve the best match between the inverse and source wavelets, affecting the accuracy of the inversion solution and the ability to obtain accurate inverted acoustic impedance (AI) data. We have conducted the joint inversion of wavelet and AI data using iterative methods, which combined the conjugate-gradient (CG) method and particle-swarm-optimization (PSO) algorithm. The Marmousi AI model was used to prove the reliability of the method. The CG-PSO algorithm achieved excellent results compared with the statistical wavelet pickup method. The wavelet obtained by the CG-PSO algorithm is preferred for inversion operations. We applied a new method to invert field data and predict the thickness and bifurcation of coal seams in the karst region. The results find that the wavelet spectrum obtained by the CG-PSO matches the spectrum map of the coal seam in the Yuwang colliery. We determined the distribution of the thickness and bifurcation of the 101 panel, Yuwang Colliery, Yunnan Province. The average error of the predicted coal thickness is 0.17 m (14.4%), which verifies the feasibility and effectiveness of the method. The method provides insights into the AI inversion of constrained waves in complex regions.
Predicting Acute Care Events Among Patients Initiating Chemotherapy: A Practice-Based Validation and Adaptation of the PROACCT Model
Authors: Stein Jacob N. , Dunham Lisette , Wood William A. , Ray Emily , Sanoff Hanna , Elston-Lafata Jennifer 
Published: May 2023

PURPOSE Acute care events (ACEs), comprising emergency department visits and hospitalizations, are a priority area for reduction in oncology. Prognostic models are a compelling strategy to identify high-risk patients and target preventive services, but have yet to be broadly implemented, partly because of challenges with electronic health record (EHR) integration. To facilitate EHR integration, we adapted and validated the previously published PRediction Of Acute Care use during Cancer Treatment (PROACCT) model to identify patients at highest risk for ACEs after systemic anticancer treatment. METHODS A retrospective cohort of adults with a cancer diagnosis starting systemic therapy at a single center between July and November 2021 was divided into development (70%) and validation (30%) sets. Clinical and demographic variables were extracted, limited to those in structured format in the EHR, including cancer diagnosis, age, drug category, and ACE in prior year. Three logistic regression models of increasing complexity were developed to predict risk of ACEs. RESULTS Five thousand one hundred fifty-three patients were evaluated (3,603 development and 1,550 validation). Several factors were predictive of ACEs: age (in decades), receipt of cytotoxic chemotherapy or immunotherapy, thoracic, GI or hematologic malignancy, and ACE in the prior year. We defined high-risk as the top 10% of risk scores; this population had 33.6% ACE rate compared with 8.3% for the remaining 90% in the low-risk group. The simplest Adapted PROACCT model had a C-statistic of 0.79, sensitivity of 0.28, and specificity of 0.93. CONCLUSION We present three models designed for EHR integration that effectively identify oncology patients at highest risk for ACE after initiation of systemic anticancer treatment. By limiting predictors to structured data fields and including all cancer types, these models offer broad applicability for cancer care organizations and may offer a safety net to identify and target resources to this high risk.
Endometriosis: Cell Death and Cell Signaling Machinery
Authors: Carbone Ginearosa , Nelson Katherine , Baumgartner Claire , Bode Ann M , Takahashi Akimasa , Chefetz Ilana 
Published: May 2023

Abstract
Endometriosis is an estrogen-dependent disorder defined as the deposition and growth of endometrial tissue outside the uterus, including but not limited to the pelvic peritoneum, rectovaginal septum, and ovaries. Endometriosis is a substantial contributor to pelvic pain and subfertility and has been associated with an increased incidence of certain cancers, including ovarian. Appropriate treatment of endometriosis can reduce morbidity, but generally is used only to address symptoms, since no cure currently exists. Multifactorial etiologies for endometriosis have been proposed, with significant evidence for genetic, immune, and environmental causes. Recent advances suggest that molecular signaling and programmed cell death pathways are involved in endometriosis, suggesting avenues for future curative treatments. The goal of this review is to examine the pathologic processes of endometriosis, focusing on cell signaling and cell death pathways, stem cells, treatment regimens, and future directions surrounding this gynecologic disorder.
Immigration and Entrepreneurship: The Role of Enclaves
Authors: Marinoni Astrid 
Published: May 2023

Immigration has proven to be a major force driving entrepreneurial dynamics. In this paper I investigate how the geographical distribution of immigrants within a given country, and in particular the presence of “enclaves,” affects the relationship between immigration and entrepreneurship. I examine the impact of Polish immigration to Great Britain following the unprecedented migration wave caused by the European Union enlargement in 2004. I address omitted variable concerns by using information on the location of historical Polish military settlements and the occupational composition and growth of Polish immigration in Ireland to construct instruments for enclaves and location choices of immigrants. The econometric results indicate, on the one hand, that immigration does increase immigrant entrepreneurship, but not in existing immigrant enclaves. On the other hand, immigrant entrepreneurs outside enclaves tend to achieve worse growth outcomes than those in enclaves. Further analyses provide an explanation to these findings due to blocked labor markets and to the higher prevalence of “necessity entrepreneurship” outside of enclaves. These results offer new insights to understand the influence of geography on entrepreneurship in the presence of immigration. This paper was accepted by Toby Stuart, entrepreneurship and innovation. Supplemental Material: The data files and online appendix are available at https://doi.org/10.1287/mnsc.2023.4776 .