bluuebunny/crossref_metadata_2025_split huggingface dataset:
Subtilisin 3 production from Microsporum canis is independent of keratin substrate availability
Authors: Moskaluk Alex E. , Darlington Lauren , VandeWoude Sue 
Published: August 2023

AbstractDermatophytes are highly infectious fungi that cause superficial infections in keratinized tissues in humans and animals. This group of fungi is defined by their ability to digest keratin and encompasses a wide range of species. We investigated a critical adhesion protein, subtilisin 3, utilized by Microsporum canis during initial stages of infection, analyzing its production and expression under varying growth conditions. Additionally, as this protein must be expressed and produced for dermatophyte infections to occur, we developed and optimized a diagnostic antibody assay targeting this protein. Subtilisin 3 levels were increased in culture when grown in baffled flasks and supplemented with either l‐cysteine or cat hair. As subtilisin 3 was also produced in cultures not supplemented with keratin or cysteine, this study demonstrated that subtilisin 3 production is not reliant on the presence of keratin or its derivatives. These findings could help direct future metabolic studies of dermatophytes, particularly during the adherence phase of infections.
Sodium fatty alcohol polyoxyethylene ether carboxylate/cationic surfactant binary system for high‐salt oil reservoir
Authors: Lu Guoqiang , Mu Meng , Liu Heng , Guo Shuang , Tang Xutao , Zhang Yongmin 
Published: August 2023

AbstractHigh salinity has been a major challenge in oil recovery. Here, two binary systems composed of sodium fatty alcohol polyoxyethylene ether carboxylate (AECM) and cationic surfactants, cetyltrimethylammonium bromide (CTAB) and cetylpyridinium chloride (CPyCl) were developed. Their fundamental properties; namely, oil/water interfacial tension, wettability, emulsification, adsorption, and oil‐washing were investigated and compared. The results showed that both AECM–CTAB (4:6–7:3, m/m) and AECM–CPyCl (5:5–6:4, m/m) could decrease oil/water interfacial tension below 10−2 mN/m. Even the total salinity was close to 200,000 mg/L after 7 days of quartz sand adsorption, showing a good interfacial activity and excellent anti‐adsorption properties. All these compound drives could effectively change the wettability of the glass surface, which reduced the contact angle to a minimum of 54.76°. In addition, the emulsification time could reach up to 24 h at 85°C, with excellent emulsification performance at high temperatures. The oil washing efficiency could reach 74.68% after 48 h. According to our comprehensive analysis, the best formulation was obtained at AECM/CTAB ratio of 5:5.
The Amazon shelf sediments, a reactor that fuels intense nitrogen cycling at the seabed
Authors: Choisnard Noémie , Burtscher Emma , Forster Stefan , Frey Claudia , Moros Matthias , Voss Maren 
Published: August 2023

AbstractLarge river plumes such as the Amazon River Plume are known as regions of intense biological, chemical, and physical forcing affecting the delivery and speciation of nutrients. On the shelf, sediments may act as a net source or sink of dissolved inorganic nitrogen (DIN) for the water column depending on the preservation of organic matter (OM) and its remineralization pathways in benthic environments. Previous studies on sediments of the Amazon shelf suggested that the seabed mainly acted as a sink of DIN, with denitrification as the main loss process. However, the Amazon Basin faced drastic changes over the past decades, with climate change, deforestation, and damming potentially impacting the DIN and OM loads to the estuary. These perturbations might have led to changes in benthic remineralization, calling for updates of previously studied benthic remineralization processes on the Amazon shelf. Our analysis of eight short cores confirmed the occurrence of intense recycling of mostly terrestrial material (> 60%) in the river mouth, and little organic carbon was remaining in shelf sediments. We measured a sediment oxygen demand of ~ 23 mmol m−2 d−1, which can explain the ammonification and nitrification of all the organic nitrogen (N) reaching the sediment, underlining the importance of the seabed as a sink for organic N species. Therefore, in spite of the changes in the Amazon Basin, nitrification still seems to be balanced by denitrification, as, similarly to previous results, no DIN diffused out of the sediment.
Recent progress of bio‐printed PEGDA‐based bioinks for tissue regeneration
Authors: Hamedi Elham , Vahedi Negin , Sigaroodi Faraz , Parandakh Azim , Hosseinzadeh Simzar , Zeinali Faezeh , Khani Mohammad‐Mehdi 
Published: August 2023

AbstractThree‐dimensional (3D) bioprinting is a promising method for the fabrication of tissue engineering constructs. The bioprintable materials with cells or other biological parts, which are called bioinks, are arranged layer by layer and make multicellular structures. Not all materials can be printed, and a set of requirements should be met to formulate the appropriate bioink. Poly (ethylene glycol) (PEGDA), as a synthetic polymer, is a promising choice for regenerative medicine applications due to its biocompatibility, ease of crosslinking, and adjustability of its mechanical and chemical properties depending on the application. This review aims to guide and familiarize the reader with the PEGDA‐based bioink as a raw material of the 3D‐bioprinting method, its properties, and applications in soft and hard tissue engineering.
ST6GAL1‐mediated aberrant sialylation promotes prostate cancer progression
Authors: Scott Emma , Archer Goode Emily , Garnham Rebecca , Hodgson Kirsty , Orozco‐Moreno Margarita , Turner Helen , Livermore Karen , Putri Nangkana Kyla , Frame Fiona M , Bermudez Abel , Jose Garcia Marques Fernando , McClurg Urszula L , Wilson Laura , Thomas Huw , Buskin Adriana , Hepburn Anastasia , Duxfield Adam , Bastian Kayla , Pye Hayley , Arredondo Hector M , Hysenaj Gerald , Heavey Susan , Stopka‐Farooqui Urszula , Haider Aiman , Freeman Alex , Singh Saurabh , Johnston Edward W , Punwani Shonit , Knight Bridget , McCullagh Paul , McGrath John , Crundwell Malcolm , Harries Lorna , Heer Rakesh , Maitland Norman J , Whitaker Hayley , Pitteri Sharon , Troyer Dean A , Wang Ning , Elliott David J , Drake Richard R , Munkley Jennifer 
Published: August 2023

AbstractAberrant glycosylation is a universal feature of cancer cells, and cancer‐associated glycans have been detected in virtually every cancer type. A common change in tumour cell glycosylation is an increase in α2,6 sialylation of N‐glycans, a modification driven by the sialyltransferase ST6GAL1. ST6GAL1 is overexpressed in numerous cancer types, and sialylated glycans are fundamental for tumour growth, metastasis, immune evasion, and drug resistance, but the role of ST6GAL1 in prostate cancer is poorly understood. Here, we analyse matched cancer and normal tissue samples from 200 patients and verify that ST6GAL1 is upregulated in prostate cancer tissue. Using MALDI imaging mass spectrometry (MALDI‐IMS), we identify larger branched α2,6 sialylated N‐glycans that show specificity to prostate tumour tissue. We also monitored ST6GAL1 in plasma samples from >400 patients and reveal ST6GAL1 levels are significantly increased in the blood of men with prostate cancer. Using both in vitro and in vivo studies, we demonstrate that ST6GAL1 promotes prostate tumour growth and invasion. Our findings show ST6GAL1 introduces α2,6 sialylated N‐glycans on prostate cancer cells and raise the possibility that prostate cancer cells can secrete active ST6GAL1 enzyme capable of remodelling glycans on the surface of other cells. Furthermore, we find α2,6 sialylated N‐glycans expressed by prostate cancer cells can be targeted using the sialyltransferase inhibitor P‐3FAX‐Neu5Ac. Our study identifies an important role for ST6GAL1 and α2,6 sialylated N‐glycans in prostate cancer progression and highlights the opportunity to inhibit abnormal sialylation for the development of new prostate cancer therapeutics. © 2023 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland.
A simultaneous Eigen valued expression to model the three coupled electronic states with triply and doubly degenerate seams together I
Authors: Xavier F. George D 
Published: August 2023

AbstractThe accurate modeling of triply and doubly degenerate seam together while computing the coupled multiple potential energy surfaces globally remains a challenging task due to the unavailability of a suitable model function taking care of this aspect. In this paper, we present such a function capable of predicting many‐fold electronic degeneracies simultaneously as well as the features found away from the vicinity of such degeneracies if present in the coupled surfaces disregarding the symmetry requirements. The basis of the proposed model comes from the analytical diagonalization of a real valued diagonally symmetric diabatic matrix and thus, the resulting three symbolic Eigen valued functions form the basis of model to be used in this work. From the analytical model, an attempt was made to provide an analytical expression for the adiabatic‐diabatic transformation angle. Few applications were considered starting from the simple physical model systems to actual realistic molecule illustrating how the present model function are being applied to them to show the presence of degeneracies among the three electronic states.
Filter‐based robust model‐free adaptive funnel control for discrete‐time nonlinear systems with jumped reference signal
Authors: Cheng Yun , Ren Xuemei , Zheng Dongdong 
Published: August 2023

AbstractThis article proposes a filter‐based robust model‐free adaptive funnel control for discrete‐time nonlinear systems with measurement noise and jumped reference signal. To suppress the effects of measurement noise on the estimated dynamic linearized model, a robust projection algorithm with filtered output is designed to estimate the pseudo‐partial derivative vector. Based on this estimated model, a novel discrete‐time funnel function‐based switching sliding‐mode surface is proposed to cope with the problem of the jumped reference signal. A time‐varying weighting factor‐based cost function is proposed in the controller design to reduce the control consumption whenever the tracking error exceeds the actual performance funnel, and the time‐varying weighting factor is tuned by a designed event‐triggered mechanism. Furthermore, the performance margin, tolerable uncertainties, and parameter selections have been analyzed in detail. Simulations and experimental results verify the effectiveness of the proposed robust control strategy.
Catalytic Hydrogenation of Furfural over UiO‐66‐NH2‐derived Ru‐based Catalysts: Precursor Coordination Structure for Enhanced Catalysis
Authors: Zhu Lingyi , Xia Xinxin , Yu Hongyang , Wang Yanyan , Song Hua , Li Cuiqin , Li Feng 
Published: August 2023

AbstractThe −NH2 in UiO‐66‐NH2 was functionally modified with 2‐pyridinecarboxaldehyde to form Schiff base UiO‐66‐Pyr, and hollow nitrogen‐doped porous carbon‐ZrO2 supported Ru (Ru/NC‐ZrO2) was prepared from Ru3+‐coordinated UiO‐66‐Pyr‐Ru. Then the furfural hydrogenation performance of the product was investigated. Compared with single‐tooth‐coordinated UiO‐66‐NH2, the 2‐tooth‐coordinated UiO‐66‐Pyr can improve the stability of Ru3+ coordination and thereby increase the Ru loading and dispersity in the Ru/NC‐ZrO2, showing high furfural hydrogenation activity. The direct hydrogenation with hydrogen as the hydrogen source and the transfer hydrogenation with isopropanol as the hydrogen donor was determined by the furfural hydrogenation of Ru/NC‐ZrO2 under hydrogen or nitrogen.
Effect of Terminal Alkyl Chains for Free Radical Photopolymerization Based on Triphenylamine Oxime Ester Visible‐Light Absorbing Type I Photoinitiators
Authors: Hsieh Jyun‐Bin , Yen Shih‐Chieh , Hammoud Fatima , Lalevée Jacques , Chen Yung‐Chung 
Published: August 2023

AbstractIn order to investigate the photopolymerization properties of the alkyl chain length dependence Type I photoinitiators, in this study, a series of visible‐light‐absorbing triphenylamine oxime esters (Peko‐A‐D, and reference TP‐1M) containing various alkyl chain length in the periphery were synthesized. That is, an alkane segment contains isopropyl for Peko‐A, butyl for Peko‐B, undecane for Peko‐C, pentadecane for Peko‐D and methyl for TP‐1M, respectively. Except for Peko‐D, all of them have good organo‐solubility and can dissolve in testing monomer (trimethylolpropane triacrylate, TMPTA). All the oxime esters give from near UV to visible‐light absorption regions with maximum absorption peaks at around 360 nm and show rather red‐shifted compared to the commercial OXE‐01 compound. Accordingly, the photochemical reaction behavior was studied by cyclic voltammograms (CV), electron spin resonance (ESR) and steady‐state photolysis. In addition, the oxime esters based photoinitiating systems are studied through photo‐DSC experiment based on various light exposure wavelengths (UV lamp, LED@365 nm and LED@405 nm). Under different light source, the penetration affects the final double conversion efficiencies. As a result, all the oxime esters‐based formulation shows better double conversion efficiencies upon LED@405 nm as an irradiation source. Finally, the new oxime ester photoinitiating system was capable applied in direct laser write to generate 3D patterns using a laser diode @405 nm.
Ionic Liquid‐Assisted Depolymerization of Condensation Polymers: A Review
Authors: Chaudhary Anvita , Srivastava Richa 
Published: August 2023

AbstractPlastic pollution has become a primary environmental concern in recent years that affects not only the environment but also wildlife and human health. Developing new, alternative ways to reduce and recycle plastic waste is an important and pressing challenge for industries, given its significant impact on greenhouse gas emissions, resource efficiency improvement, and landfilling reduction. Currently, reuse and mechanical recycling are the most employed routes to exploit post‐consumer plastics, but they have their own limitations. Chemical recycling of plastic is a process that offers a sustainable solution to the growing plastic waste problem. But the depolymerization of condensation polymers poses a lot of challenges in chemical recycling. Ionic liquids (ILs) have recently emerged as depolymerization reagents offering various advancements in polymer recycling and waste management. This review assesses the different recycling conditions using ILs for different condensation polymers such as polyesters, polyamides, polycarbonates, and polyethylene terephthalate. It also explores the possibility of using ionic liquid as a catalyst influencing depolymerization efficiency. This review is intended to build on existing knowledge and inform further research in the area of sustainable polymer recycling.
Hydride Locations and Planar σ‐Aromaticity in Hydrido‐Coinage‐Metal Clusters
Authors: Zhang Manli , Zhu Qiyong , Liu Qiman 
Published: August 2023

AbstractThe atomic‐scale analysis of hydrides within metal clusters remains challenging due to the difficulties in performing spatially resolved characterization experiments. One important issue is understanding how hydrogens bond to metal atoms and their positions. The classification of hydride as either a ligand or doped metal is a difficult problem due to its different impacts on electronic structures of coinage metal (Cu, Ag, and Au) clusters. Here, geometric characteristics, stability and electronic properties of MnH (M=Cu, Ag and Au;n=2–9) clusters are investigated in detail. We find that structure transitions of CunH and AgnH occur atn=5, while all AunH are more inclined to planar configurations, where H atoms prefer to be located on the bridge positions of M−M regardless of different sizes and configurations. Among them, the planar M5H clusters have the same structural framework and higher stability than their neighbors. The AIMD simulations demonstrate that these three clusters still show excellent thermal stability at 700 K. The molecular orbitals and AdNDP analyses reveal that the M5H clusters exhibit three six‐center two‐electron σ bonds throughout whole structural spaces and conform to σ aromaticity rule, which are also further confirmed by the ELF, LOL and NICSzz‐scan analyses.
Photo‐Assisted Fenton Reaction for the Oxidative Degradation of Organic Pollutants in Water Using a Layered Double Hydroxide of Iron Ion
Authors: Akagi Taisei , Fuku Kojiro , Todoroki Masanobu , Ikenaga Naoki 
Published: August 2023

AbstractThe Fenton reaction is widely known as a promising method for treating organic pollutants. We investigated the photo‐assisted oxidative degradation of pollutants using various layered double hydroxides (LDHs) to develop heterogeneous Fenton catalyst capable of mineralizing organic pollutants. A LDH composed of Fe2+ and Al3+ (Fe2+Al3+‐LDH) under the irradiation of visible‐light (λ>420 nm) resulted in 2.5 times higher performance for the oxidative degradation (mineralization) of phenol as a model compound of organic pollutants compared with that without light irradiation. The ratio of Fe2+/Fe3+ on the surface of the Fe2+Al3+‐LDH after the reaction under the irradiation of visible‐light increased significantly compared with that without light irradiation. These indicated that the Fenton‐catalytic‐cycle was improved by reducing the Fe3+ generated after the Fenton reaction to the Fe2+ species by the photo‐assisted effects of the Fe2+Al3+‐LDH.
Direct Arylation of Thiophenes in Continuous Flow
Authors: Petronilli Alessandro , Carofiglio Tommaso , Zardi Paolo 
Published: August 2023

AbstractSynthetic methodologies involving direct C−H functionalization are promising to improve sustainability in organic synthesis. However, these newly developed strategies may have a scarce appeal for larger scale applications due to the high catalyst loading, harsh conditions or their typically long reaction times that affect severely the process productivity. Flow chemistry technology is a recognized tool to improve both the efficiency and scalability in organic synthesis that can overcome these issues. In the present paper we studied an “in flow” method for the direct arylation of thiophene derivatives with aromatic bromides to promptly afford heteroaromatic biaryls, which are recurrent motifs both in biologically active molecules and in functional materials. By using a packed‐bed reactor containing potassium carbonate as the solid base and an automated system, we could develop a reliable methodology for thiophene arylation in flow with yields up to 90 % within a residence time of 30–60 minutes. This strategy is suitable for a wide variety of substrates and allowed the reaction to be carried out at gram‐scale reaching a productivity value of 1.1 g h−1.
N6‐methyladenosine methylation regulator RBM15 promotes the progression of diabetic nephropathy by regulating cell proliferation, inflammation, oxidative stress, and pyroptosis through activating the AGE‐RAGE pathway
Authors: Qin Yongzhang , Wu Suzhen , Zhang Fengxia , Zhou Xueyan , You Cong , Tan Fei 
Published: August 2023

AbstractBackgroundDiabetic nephropathy (DN) is a major cause of end‐stage renal disease throughout the world, and m6A modification plays a critical role in the progression of DN. We aimed to find m6A‐related genes and their regulatory mechanisms in DN.MethodsThe expression levels of four important m6A‐related genes (METTL16, RBM15, IGF2BP1, and ALKBH5) were detected by quantitative real‐time PCR (RT‐qPCR). RBM15 was chosen and its function was explored. The downstream pathway of RBM15 was screened by transcriptome sequencing. The levels of AGE, inflammation, and oxidative stress were determined with enzyme‐linked immunosorbent assay, and the expression of AGE‐RAGE pathway‐related proteins were detected by Western blot (WB). Cell proliferation was assessed by Cell counting Kit‐8 (CCK‐8). The levels of pyroptosis‐related proteins were evaluated by RT‐qPCR or WB.ResultsMETTL16 and RBM15 were up regulated in the mouse model of DN, in which RBM15 was more significant. Silencing RBM15 recovered cell proliferation, reduced the levels of inflammation factors, and inhibited cell pyroptosis in high glucose‐induced HK‐2 cells. Transcriptome sequencing suggested that the AGE‐RAGE pathway might be downstream of RBM15. RBM15 knockdown reduced AGE level and the expression of AGE‐RAGE pathway‐related proteins. After silencing RBM15, we found that activating the AGE‐RAGE pathway inhibited cell proliferation, increased the levels of inflammation factors, promoted oxidative stress, and induced cell pyroptosis in HK‐2 cell model of DN.ConclusionThe m6A‐related gene RBM15 inhibited cell proliferation, promoted inflammation, oxidative stress, and cell pyroptosis, thereby facilitating the progression of DN through the activation of the AGE‐RAGE pathway.
Overview of factors influencing consumer engagement with plastic recycling
Authors: Ertz Myriam , Addar Walid , Ouerghemmi Chourouk , Takaffoli Mahdi 
Published: August 2023

AbstractMany semi‐durable and durable consumer goods are composed of plastic. Yet, plastic pollution is one of the most pressing environmental issues as it harms oceans and marine biodiversity. This state of affairs is worsened because plastic recycling rates remain low. Therefore, one commonly proposed solution is to improve plastic waste management to create a circular plastics economy. However, focusing on recycling management alone overshadows the consumption component and how consumers might contribute to recycling efforts. Although not alone in the overall recycling process, consumers are critical stakeholders in this because through their disposal behavior, they determine the responsible discarding of plastic through recycling. The significance of consumer engagement in driving circularity has been strongly emphasized in extant research and practice. Shifting from a linear plastic economy toward a circular one requires the active contribution of all stakeholders, especially the consumer. Hence, given the centrality of consumers' role, this paper provides an overview of the themes related to consumer engagement with plastic recycling. More specifically, the paper reveals three layers of influence on consumer plastic recycling behavior: (1) macroenvironmental factors, (2) situational factors, and (3) individual factors. This review provides scholars, practitioners, and decision‐makers with better insights into the themes to consider in order to spur consumer engagement in plastic recycling.This article is categorized under:
Human and Social Dimensions > Behavioral Science
Emerging Technologies > Materials
Climate and Environment > Circular Economy
Synthesis and characterization of ternary trielides Na7KTr4 [Tr=In or Tl] including [Tr4]8− Tetrahedra
Authors: Janesch Melissa , Schwinghammer Vanessa F. , Shenderovich Ilya G. , Gärtner Stefanie 
Published: August 2023

AbstractTwo new ternary trielides Na7KTr4 (Tr=In, Tl) have been prepared by classical solid‐state reaction from the elements in tantalum ampoules. Both are isostructural to Na7RbTl4 and therefore crystallize in the orthorhombic space group Pbam, Pearson symbol oP96 (a=b=16.3283(2)/16.2860(6), c=11.3094(17)/11.2771(4), V=3015.25(8)/2991.07(18), Z=8, R1, wR2=0.0249, 0.0386/0.0447, 0.0608). The trielide subunit is built by two crystallographically independent [Tr4]8− tetrahedra. 23Na‐MAS‐Nuclear Magnetic Resonance (NMR) as well as EPR spectroscopy was employed to characterize the compounds further. DOS calculations showed a (pseudo) band gap at EF for both compounds. Dissolution experiments in liquid ammonia were carried out for the two alkali metal indides Na7KIn4 and Na2In according to the chemistry of group 14 and 15 Zintl anions. After evaporating the solvent, the remaining material was analyzed by powder X‐ray diffraction and proved the formation of NaIn and NaNH2.