bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pathogenetic therapy of mitral valve prolapse
Authors: Malev E. G. , Reeva S. V. , Omelchenko M. Yu. , Mitrofanova L. B. , Timofeev E. V. , Parfenova N. N. , Luneva E. B. 
Published: February 2025

Aim. To evaluate the effect of angiotensin II receptor blocker (ARB) therapy on the expression of transforming growth factor-β (TGF-β) in the myxomatous mitral valve, on the serum levels of TGF-β1/TGF-β2 and the left ventricular (LV) systolic function in patients with mitral valve prolapse (MVP).Material and methods. The retrospective non-randomized single-center study included 233 patients who underwent surgical treatment of severe mitral regurgitation due to MVP. Preoperative drug therapy was assessed using case records. Transthoracic echocardiography was performed in all patients before surgery. Pathological and immunohistochemical analysis of mitral valve fragments removed during surgery were performed. The serum content of TGF-β1 and TGF-β2 was determined by the enzyme immunoassay.Results. According to echocardiography, mitral valve leaflets were significantly longer and thicker in patients in the control group than in the ARB group. These data were confirmed by pathological study — most patients in the control group had excessive myxomatous mitral valve leaflets (χ2=7,9; p=0,005). In the ARB group, the expression of type III collagen in the mitral valve leaflets was lower compared to the control group and the expression of fibulin-5 did not differ. Also, in the main group, an increased density of valvular interstitial cells was found, including those expressing TGF-β1 and TGF-β2 compared to the control group. The serum level of TGF-β1 and TGF-β2 was significantly higher in the control group than in the ARB group.Despite the absence of differences in LV ejection fraction between the groups, global longitudinal systolic strain and strain rate were significantly higher in the main group.Conclusion. This is the first study to reveal a positive effect of ARB therapy on myxomatous mitral valve degeneration and LV function due to inhibition of the TGF-β signaling pathway, which opens up potential for pathogenetic therapy in patients with MVP.
Dynapenia and presarcopenia in patients with coronary atherosclerosis: clinical predictors and cardiac structural and functional features
Authors: Neeshpapa A. G. , Karetnikova V. N. , Krivoshapova K. E. , Karpova E. I. , Kokov A. N. , Barbarash O. L. 
Published: February 2025

Aim. To assess the prevalence of dynapenia, presarcopenia and their relationship with structural and functional parameters of the heart in patients with coronary atherosclerosis.Material and methods. The study included 136 people with stable types of coronary artery disease (CAD). Hand grip test was performed to measure muscle strength. In women, a decrease in grip strength of <16 kg was a sign of decreased muscle strength, while in men — <27 kg (according to the guidelines of the Writing Group for the European Working Group on Sarcopenia in Older People 2 of 2019). All patients underwent computed tomography with skeletal muscle index (SMI, cm2/m2) estimation. The threshold values of SMI, a decrease in which was regarded as a decrease in muscle volume, were 52,4 cm2/m2 for men and 38,5 cm2/m2 for women. If patients had an isolated decrease in SMI according to computed tomography, the condition was classified as presarcopenia. With a decrease in muscle strength according to the hand grip test, the condition was classified as dynapenia. All patients underwent echocardiography using a standard technique.Results. The analysis revealed that individuals with presarcopenia were exclusively male and were taller (175 (168; 179) cm) than those with normal muscle mass (166 (159; 172,5) cm (p=0,001)), but the body mass index in presarcopenia was lower (27,3 (24,4; 30,3) kg/m2 and 29,5 (25,8; 33,1) kg/m2) in individuals without this pathology (p=0,02). When comparing echocardiographic parameters, a lower left ventricular (LV) ejection fraction was found among patients with presarcopenia. The LV end-diastolic volume (EDV), LV end-systolic volume (ESV), LV end-diastolic dimension (EDD), and LV end-systolic dimension (ESD) were greater in the group of patients with presarcopenia compared to other patients (p<0,05). Patients with presarcopenia were more likely to have prior myocardial infarction — 24 patients (68,6%) versus 41 (46,6%) in the group without presarcopenia (p=0,02). Patients with dynapenia differed in the following parameters: they were older (68 (65,6; 71,4) years versus 65 years (63; 67,9) in rest of the sample), mostly women (74,2%) and shorter (164 (159,6; 165,4) cm) compared to individuals without dynapenia (170 (168; 172) cm (p<0,05)). Patients with dynapenia were more likely to have prior type 2 diabetes and chronic kidney disease (p<0,05).Conclusion. Patients with presarcopenia and CAD more often have prior myocardial infarction and larger LV size and volume. Patients with dynapenia and coronary atherosclerosis are more often female, have shorter stature, and more often had chronic kidney disease and diabetes.
Analysis of risk factors for aortic stenosis in patients with familial hypercholesterolemia
Authors: Korneva V. A. , Kuznetsova T. Yu. 
Published: February 2025

Aim. To analyze factors influencing the development of aortic stenosis (AS) in patients with heterozygous familial hypercholesterolemia (heFH).Material and methods. A total of 114 patients with heFH were examined (mean age 54,3±2,7 years, 85 men (69,1%)), of whom 10 (8,8%) had AS. FH was diagnosed according to the Dutch Lipid Clinic Network criteria. Lipid profile parameters, lipoprotein(a) (Lp(a)) level, age, family history of cardiovascular disease, smoking, hypertension (AH), hyperglycemia were analyzed. The history of coronary artery disease (CAD), myocardial infarction (MI), and ischemic stroke was taken into account. Cumulative levels of low-density lipoprotein (LDL) and non-HDL cholesterol were calculated as the total LDL-C over the patient's life, taking into account the levels achieved during lipid-lowering therapy.Results. AS development was influenced by age (odds ratio (OR) 1,1 [1,02; 1,15], p=0,009), HTN (OR 8,15 [1,50; 44,08], p=0,017), lipid profile parameters: total cholesterol (OR 2,09 [1,38; 3,10], p=0,0006; LDL-C (OR 2,8 [1,59; 4,79], p=0,0004), non-HDL-C (OR 1,012 [1,005; 1,019], p=0,003), triglycerides (OR 1,97 [1,33; 2,87], p=0,0007). Cumulative indicators also influenced the risk of AS: cumulative LDL accumulated over the years of life (OR 2,13 [1,31; 3,54], p=0,003), cumulative non-HDL-C level accumulated over life (OR 1,56 [1,01; 2,18], p=0,013), Lp(a) level (AS risk increases by 10,6 times with an increase in Lp(a) by 1 unit of measurement (1 g/l) (OR 10,5 [5,0; 21,9], p=0,0017). The presence of CAD and MI in FH increases the risk of AS (for CAD, OR 8,62 [1,07; 69,113], p=0,044; for MI, OR 3,93 [1,08; 14,36], p=0,034). The combination of MI and cerebrovascular accident increases the risk of AS by 4,94 (OR 4,94 [1,23; 19,62], p=0,021). Tendon xanthomas significantly affects the AS (OR 50,2 [6,03; 413,00], p<0,001).Conclusion. AS detected at a young age can be a manifestation of FH. The development of AS in FH is influenced by age and HTN, and following lipid factors: total cholesterol, LDL, triglycerides, as well as Lp(a) levels and cumulative indicators.
Role of 99mTc-pyrophosphate myocardial scintigraphy in assessing the efficiency of tafamidis therapy: a case series
Authors: Shoshina A. A. , Ansheles A. A. , Nasonova S. N. , Zhirov I. V. , Sergienko V. B. , Tereshchenko S. N. 
Published: February 2025

Introduction. In recent years, the detection rate of transthyretin amyloid cardiomyopathy has been rapidly increasing. The only drug registered as a pathogenetic therapy in Russia is tafamidis. To date, there is no single protocol for assessing disease progression, and the role of scintigraphy with phosphate complexes is not reflected in current documents due to the lack of evidence.Brief description. The article presents a case series including patients who received tafamidis therapy for at least 12 months. During therapy, there were no signs of disease progression, and in some cases, according to myocardial scintigraphy with phosphate complexes, a decrease in radiopharmaceutical uptake was noted.Discussion. The role of myocardial scintigraphy with phosphate complexes for monitoring the effectiveness of tafamidis therapy was discussed.
Efficacy of buffered and enteric-coated acetylsalicylic acid on platelet aggregation in patients with stable coronary artery disease and type 2 diabetes (CASCADE): rationale and design of a single-center observational comparative study
Authors: Kobalava Zh. D. , Pisaryuk A. S. , Filkova A. A. , Tukhsanboev E. S. , Amirova A. N. , Korneichuk A. D. , Pavlikov G. S. , Burkhanova L. R. , Meray I. A. , Panteleev M. A. , Sveshnikova A. N. 
Published: February 2025

Aim. Enteric-coated acetylsalicylic acid (ASA) is released more slowly and is absorbed in smaller quantities and over a longer period of time, which may lead to bioavailability and antiplatelet effect decrease compared to conventional ASA. Patients with diabetes are characterized by increased platelet reactivity and a reduced pharmacodynamic response to ASA compared to individuals without diabetes. It seems rational to test the hypothesis that the use of ASA absorbed in the stomach may be more effective in patients with type 2 diabetes mellitus (T2D) and stable coronary artery disease (CAD).Material and methods. This single-center, non-interventional comparative study will randomly select 200 adult patients of both sexes with stable CAD and T2D who were routinely prescribed a gastro-soluble ASA (Cardiomagnyl 75 mg/day) or an enteric-soluble ASA (Aspirin® Cardio 100 mg/day or Thrombo ASS® 100 mg/day) before inclusion in the study. According to the routinely prescribed therapy, patients will be divided into 2 following groups: patients taking Cardiomagnyl 75 mg/day and patients taking Aspirin® Cardio 100 mg/day or Thrombo ASS® 100 mg/day. The primary endpoint is the incidence of high residual platelet reactivity (HRPR) while taking ASA (resistance to ASA) according to the VerifyNow Aspirin Test.Conclusion. CASCADE is the first study to evaluate the HRPR using the VerifyNow Aspirin Test in patients with stable CAD and T2D.
Transfusion associated graft versus host disease following whole blood transfusion: an unusual case of expanded dengue syndrome
Authors: Misra Krushna Chandra , Kumar Garipalli Srinivas Nikilesh , Munta Kartik , Hariprasad A. , D. Shiva Kumar G. 
Published: February 2025

Dengue infection presents in a diverse array of manifestations, including dengue fever (DF), dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS). To include cases that do not fit the criteria for either DHF or DSS and show atypical manifestations across multiple organ systems, world health organization (WHO) coined the term expanded dengue syndrome (EDS). A 47-yr-old female presented with fever, chills, blanchable rash, itching and burning sensation all over body with skin peeling over the last 5 days. In the outside hospital, she developed melena and thrombocytopenia, for which she received 1unit packed red blood cells, 1 unit of single donor platelets from her brother. After 1 week she developed above symptoms and was referred to us for pancytopenia. On evaluation her platelets, leucocyte count was low with normal Hb levels. The bone marrow biopsy revealed a hypoplastic marrow accompanied by significant proliferation of pre-progenitor megakaryocytes. She had mild transaminitis, without hyperbilirubinemias. Blood culture grew candida spp, Enterococcus faecium. She received appropriate antibiotics along G-CSF. Skin biopsy revealed basal vacuolation, spongiosis in epidermis, necrotic epidermis, apoptotic keratinocytes scattered in intact epidermis suggestive of acute GVHD Gr-Ⅲ. Consequently, she was commenced on pulsed steroid regimen followed by maintenance dose. Within a week, her clinical condition improved and was discharged on tapering dose of steroids. The existence of donor-derived cells or DNA in the recipient's blood or afflicted tissues must be documented to make conclusive diagnosis of TA-GVHD.
Identification And Correction Of Pseudowords In Ilman Wa Ruhan Textbooks To Reduce Meaning Errors/ التعرف على الألفاظ الزائفة وتصحيحها في الكتاب المدرسي علما وروحا للحد من المعاني الخاطئة
Authors: Jundi Ahmad , Kharolina Kharolina Ghadami , Baihaqi M , Zaenuri Muh , D. Habib , Solihah Iis , Fatihuddin Fatihuddin 
Published: February 2025

The existence of pseudo-words in textbooks is a serious problem and requires special attention. This will certainly have a negative impact on the quality of learning and the achievement of educational goals. This research aims to reveal teaching materials that are pseudo and provide corrections to these materials so that they become more meaningful and useful for learners. This paper uses an adaptation of the qualitative content analysis method, namely identifying, and classifying. The data was obtained through direct observation of Ilman wa ruhan volume one and two textbooks that enter the word learning process. The observation instrument of this research is maany digital dictionary which has been standardized internationally. The conclusion of this study shows the existence of pseudo-words in volume one and volume two textbooks in the early part of learning three connected letters. The research findings revealed the existence of 24 pseudo-words in the form of three kinds of criteria, namely the criteria for vocal incompatibility, consonant incompatibility criteria and writing incompatibility criteria. This study contributes to the correction of these pseudo-words so that the learners read and pronounce the correct language in Arabic and the Koran. This effort is expected to improve the quality of textbooks and support the creation of a meaningful learning process for students.
Effectiveness of Cognitive Behavior Therapy (CBT) Group Counseling to Increase Self-Determination in Middle School Students
Authors: Renata Noor Inayah Oetomo  , Cindy Pravesti 
Published: February 2025

Determinasi diri menjadi faktor penting dalam menjalani kehidupan. Penyebab determinasi diri yang rendah karena adanya dominasi pikiran negatif. Determinasi diri mampu ditingkatkan dengan melalui berbagai upaya atau usaha salah satunya ialah dengan melawan pikiran negatif melalui konseling cognitive behavior therapy. Tujuan atau maksud dari penelitian ini yaitu untuk meningkatkan determinasi diri melalui kegiatan konseling kelompok cognitive behavior therapy. Penelitian kuantitatif berupa jenis pre-eksperimen one group pre-test post-test design yang mengambil sampel melalui teknik simple random sampling sehingga menjadi acuan dalam metode penelitian ini. Penerapan intstrumen atau pelaksanaan instrumen dalam penelitian ini ialah dengan menggunakan skala determinasi diri yang telah teruji validitas dan reliabilitas. Dari pelaksanaan penelitian yang telah dilakukan menyatakan bahwa hasil pelaksanaan konseling kelompok cognitive behavior therapy efektif dalam meningkatkan determinasi diri siswa kelas VIII SMP PGRI 1 Buduran Sidoarjo, dengan hasil uji statistik perhitungan uji Wilcoxon yang bernilai signifikansi (2-tailed) yaitu 0,042 < 0,05.
Are Resilience, and Spirituality Related to Marital Peace? Explorations in Silver Age Couples
Authors: Afita Nur Hayati  , Sai Handari  , Firda Karwina Awaliah  , Aulia Rahmatul Azizah  , Ikrima Bestari Agsal Kurniad  
Published: February 2025

This study aimed to determine the relationship between resilience and spirituality with marital peace in couples of silver or twenty-five years of marriage age in East Kalimantan. The approach in this study uses quantitative-qualitative methods with regression and narrative data analysis methods. Respondents in this study were married couples who were in the Qaryah Tayyibah community totaling 31 people. The results of the quantitative analysis show that resilience and spirituality can explain and influence marital peace by less than 1%. This means that the other 99% is influenced by different factors. In the F test, the results show that resilience and spirituality do not affect marital peace. The t-test is negative, indicating that the resilience variable does not affect marital peace, as well as the spirituality variable. Results of the narrative analysis of qualitative data from focus group discussions (FGDs) reveal that the resilience variable has a relationship with spirituality but no relationship with the marital peace variable. This study can provide an empirical contribution, namely the support of spirituality variables on marital resilience and effective communication, social support, and emotional intimacy to maintain a healthy relationship despite facing challenges.
GenAI in Indian Higher Education: Faculty at the Crossroads of Adoption
Authors: Rahim Mohammad Razi ur , Chauhan Jahangir , Uddin Furquan , K.P Faisal 
Published: February 2025

Abstract

While global institutions embrace GenAI to enhance education, many faculty members in India remain hesitant to adopt it. Earlier research found that only a few studies have examined the adoption of GenAI at the university level, especially in developing countries. Sparsely explores how teachers accept and use GenAI, and they failed to provide a complete picture of its adoption. It highlights a significant research gap. This study provides a complete picture of what influences faculty members in adoption of GenAI. Being, GenAI a part of an information system, a novel construct 'Output Quality' in the TAM is added. The study employed a quantitative, single cross-sectional research design. A total of 455 faculty members from higher education participated, and their responses were analyzed using CB-SEM. The study reveals that perceived ease of use drives adoption the most, followed by perceived usefulness and social norms. Output quality has the most decisive and most significant impact on perceived ease of use. Institutions can inspire GenAI adoption through incentives and recognition. The findings will guide educators, administrators, and policymakers who want to integrate GenAI into higher education.
Optimization of detention ponds for urban stormwater runoff and pollution control in multiple catchments system with analytical probabilistic models and particle swarm
Authors: Aldrees Ali , Dan'azumi Salisu , Abba Sani I. 
Published: February 2025

ABSTRACT

Guidelines are often set at urban catchments' outfalls to avert river pollution, where stormwater is discharged into the river. Analytical probabilistic models (APMs) in conjunction with particle swarm optimization (PSO) were used to design a detention pond system at three sub-catchments of a watershed that discharge into a common point. The objective is to design multiple ponds upstream such that the pollution control target downstream is met at the minimum cost. Given the cost of purchasing land plus the cost of construction/maintenance of the ponds in the sub-catchments, the result shows that pond depths of 2.0 m in all three sub-catchments give the least total cost. A runoff control of 88, 94, and 90%, and pollution control of 59, 45, and 66% were obtained in Ponds 1, 2, and 3, respectively, while satisfying the overall watershed's pollution control target. A sensitivity analysis was conducted by varying the land costs and different performances were obtained. The APM/PSO model can search for the optimum design parameters that satisfy upstream runoff control performances and the overall pollution control target downstream. The advantage of the approach is that it can be applied to any combination of ponds in a larger watershed.
Efisiensi Saluran Distribusi Pada Agribisnis Peternakan
Authors: Putra Putu Wirasanjaya , Handrito Radityo Putro 
Published: February 2025

This research aims to analyze efficient distribution channels to enhance marketing efficiency in catfish cultivation business at Top Fish Farm, Denpasar. Through interviews, SWOT analysis, Cost and Benefit analysis, and examination of various distribution model business, this study provides recommendations for determining the best distribution channels. The distribution channel models tested include sales to collectors, direct sales, farmers market, e-commerce, box delivery, on farm sales, and pick your own. The findings suggest that integrating several distribution models is an effective strategy to build brand and expand market. In the current production capacity, utilizing a combination of Direct Sales, E-Commerce, Box Delivery, and On Farm Sales enables Top Fish Farm to better respond to diverse market demands. Meanwhile, in business expansion with the assumption of production increasing to 100Kg per day, the primary focus is on Direct Sales to restaurants and traditional eateries, with significant emphasis on Box Delivery. This research provides a strong foundation for Top Fish Farm to design distribution strategies aligned with its business objectives, meet customer demands, and achieve sustainable growth in the fisheries industry.

Abstrak
Penelitian ini bertujuan untuk menganalisis saluran distribusi yang efisien untuk meningkatkan efisiensi pemasaran pada usaha budidaya ikan lele di Top Fish Farm, Denpasar. Melalui wawancara dan analisis SWOT, Cost and Benefit dari berbagai model distribusi, penelitian ini memberikan rekomendasi untuk penentuan saluran distribusi terbaik. Model saluran distribusi yang diujikan adalah penjualan ke pengepul, direct sales, farmers market, e-commerce, box delivery, on farm sales, dan pick your own. Hasil penelitian menunjukkan bahwa integrasi beberapa model distribusi adalah strategi yang efektif untuk membangun merek dan memperluas pasar. Dalam kapasitas produksi saat ini, penggunaan kombinasi Direct Sales, E-Commerce, Box Delivery, dan On Farm Sales akan memungkinkan Top Fish Farm merespons permintaan pasar yang beragam dengan lebih baik. Sementara dalam ekspansi bisnis dengan dengan asumsi produksi meningkat menjadi 100Kg per hari, fokus utama adalah pada Direct Sales ke restoran dan warung lalapan, dengan peningkatan penting pada Box Delivery. Penelitian ini memberikan landasan yang kuat bagi Top Fish Farm untuk merancang strategi distribusi yang sesuai dengan tujuan bisnisnya, memenuhi permintaan pelanggan, dan mencapai pertumbuhan yang berkelanjutan dalam industri perikanan.
Pengaruh Penggunaan Marketplace Dan Qris Terhadap Peningkatan Pendapatan Umkm
Authors: Alifiyah Putri Dwi , Purwanti Lilik 
Published: February 2025

This study aims to determine the impact of using marketplace and QRIS in increasing the income of MSMEs in Malang City. This research method uses quantitative research methods. The research population includes MSMEs in Malang City that use the marketplace and QRIS in running their businesses. This study uses primary data with data collection techniques through distributing questionnaires to 89 research samples determined using purposive sampling. The data analysis technique is classical assumption test, multiple linear regression test and hypothesis testing processed with SPSS 25 software. The results of this study indicate that the use of marketplace and QRIS together has a positive and significant effect on increasing MSME business income both partially and simultaneously.

Abstrak
Penelitian ini dilakukan untuk mengetahui pengaruh penggunaan marketplace dan QRIS terhadap peningkatan pendapatan usaha UMKM di Kota Malang. Metode penelitian ini menggunakan metode penelitian kuantitatif. Populasi penelitian mencakup UMKM di Kota Malang yang menggunakan marketplace dan QRIS dalam menjalankan usahanya. Penelitian ini menggunakan data primer dengan teknik pengumpulan data melalui penyebaran kuesioner kepada 150 sampel penelitian yang ditentukan menggunakan purposive sampling. Teknik analisis data yaitu uji asumsi klasik, uji regresi linier berganda dan uji hipotesis yang diolah dengan software SPSS 25. Hasil penelitian ini menunjukkan bahwa penggunaan marketplace dan QRIS secara bersama-sama berpengaruh positif dan signifikan terhadap peningkatan pendapatan usaha UMKM baik secara parsial maupun simultan.