bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between sensitivity to thyroid hormone indices and osteoporosis in euthyroid patients with type 2 diabetes mellitus
Authors: Wu Xuelun , Zhai Furui , Chang Ailing , Wei Jing , Guo Yanan , Zhang Jincheng 
Published: August 2023

Background: Thyroid hormones are known to regulate bone metabolism and may influence bone mineral density (BMD), as well as the risk of osteoporosis (OP) and fractures in patients with type 2 diabetes mellitus (T2DM). Recently, sensitivity to thyroid hormone indices has been linked with T2DM and OP independently. However, the relationship between thyroid hormone sensitivity and OP in euthyroid T2DM patients has yet to be investigated. Objectives: The aim of this study was to determine the association between sensitivity to thyroid hormone indices and the risk of OP in euthyroid patients with T2DM. Design: This study employed a retrospective, cross-sectional design and utilized data acquired from the Cangzhou Central Hospital in China between 2019 and 2020. Methods: We retrospectively analyzed the data of 433 patients with T2DM for anthropometric measurements, clinical laboratory test results, and BMD. The thyroid-stimulating hormone index, thyrotroph thyroxine resistance index, and thyroid feedback quantile-based index (TFQI) were calculated to determine thyroid hormone sensitivity. Finally, multivariable logistic regression, generalized additive models, and subgroup analysis were performed to detect the association between sensitivity to thyroid hormone indices and the risk of OP in these patients. Results: We did not observe a statistically significant linear relationship between sensitivity to thyroid hormones indices and OP after covariate adjustment. However, a nonlinear relationship existed between TFQI and the prevalence of OP. The inflection point of the TFQI was at −0.29. The effect sizes (odds ratio) on the left and right of the inflection point were 0.07 [95% confidence interval (CI): 0.01–0.71; p = 0.024] and 2.78 (95% CI: 1.02–7.58; p = 0.046), respectively. This trend was consistent in older female patients with higher body mass index (BMI; 25–30 kg/m2). Conclusion: An approximate U-shaped relationship was observed between sensitivity to thyroid hormone indices and OP risk in euthyroid patients with T2DM with variations in sex, age, and BMI. These findings provide a new perspective to elucidate the role of thyroid hormones in OP, specifically in patients with T2DM.
Poster 117: Dancers Following Primary Hip Arthroscopy Demonstrate Favorable Outcomes and High Rate of Return to Dance at a Minimum 5-Year Follow-Up
Authors: Maldonado David , Lee Michael , Curley Andrew , Domb Benjamin 
Published: August 2023

Objectives: The purpose is to report minimum 5-year follow-up patient-reported outcome measurement scores (PROMS) and return to dance in dancers who underwent primary hip arthroscopy, and to identify predictors for secondary surgeries Methods: Prospectively collected data from May 2010 and June 2016 was retrospectively reviewed. Patients were included if they participated in dance one year prior to surgery at any level, had preoperative and minimum 5-year follow-up scores for the modified Harris Hip Score (mHHS), Nonarthritic Hip Score (NAHS), Hip Outcome Score–Sports Specific Subscale (HOS-SSS), and Visual Analog Scale for pain (VAS). Exclusion criteria were previous hip conditions, previous ipsilateral hip surgery, Tönnis grade > 1, or lateral center-edge angle < 18°. The minimal clinically important difference (MCID), patient acceptable symptomatic state (PASS), and the maximum outcome improvement (MOI) were reported. A logistic regression model was used to identify predictors of secondary surgeries. Results: Fifty-one hips (48 female dancers) were included. The average age and follow-up were 29.8 ± 17.2 years and 79.1 ± 23.2 months, respectively. Improvement in all PROMS (P < 0.001) was reported. Achievement rates of MCID for the mHHS, NAHS and VAS were 83.3%, 85.7% and 85.7%, respectively. Achievement rates of PASS for the mHHS and the International Hip Outcome Tool–12 were 90.5% and 81%, respectively. The MOI was 73.8% for the mHHS, and 78.6% for the NAHS. Six dancers (14.3%) underwent revision hip arthroscopy and three dancers (5.8%) converted to total hip arthroplasty. The rate to return to dance was 79.1%. Femoral head Outerbridge grade was identified as a predictor for secondary surgeries [P = 0.045, odds ratio 6.752, 95% CI [1.043 – 43.688]). Conclusions: Dancers following primary hip arthroscopy experienced significant improvement in all PROMS and achieved high rates of the MCID, PASS, and MOI at a minimum 5-year follow-up. Further, 89.3% continued to dance with 68% returning to the pre-injury or higher performance level. Femoral head Outerbridge grade was found to be a predictor for secondary surgeries.
Poster 180: A prospective randomized comparative study between isolated eccentric versus conventional exercise therapy in athletes with rotator cuff tendinopathy
Authors: Dhankhar Sarita , ROHILLA RAJESH 
Published: August 2023

Objectives: To compare the effectiveness of an isolated Eccentric exercise program versus Conventional exercise program in athletes with rotator cuff tendinopathy. Methods: The study included 80 athletes with rotator cuff (RC) tendinopathy (diagnosed on Magnetic resonance imaging) presenting to author’s tertiary level institute. Patients were randomized into two groups of 40 each. The eccentric exercise group (n = 40, mean age = 26.4years ) received an isolated eccentric training combined with stretching, while the conventional exercise group received scapular stabilization exercises, concentric RC strengthening exercises and stretching. (n = 40, mean age = 25.2years). Patients in both groups fulfilled 12 week daily home based exercise program and received treatments twice a week for 3 months. Primary outcome measures were shoulder pain (a 0–100mm Visual Analog Scale; VAS) and function measured with the Constant Murley score and Disabilities of the Arm, Shoulder and Hand (DASH) score. Secondary outcome measures were isometric abduction strength in 45° in the scapular plane (Hand held dynamometer) and shoulder range of motion (forward elevation, abduction and external rotation). All measurements were taken at baseline, at 12, and 24weeks. There was no statistically significant difference in pre-intervention scores between two groups. The study was approved by Institutional Review Board. Results: After 24 weeks, both groups showed a significant decrease in VAS scores and DASH score and a significant increase in the Constant Murley score. No statistically significant differences were found between the groups for any of the evaluated outcome measures. In the EE group, there was a slight deterioration in both CM and VAS scores between 12 and 24 weeks, but this did not reach statistical significance. Both groups also had a significant increase in isometric muscle strength between baseline and 24 weeks. Conclusions: A 12 week isolated eccentric training program of the rotator cuff is as effective (but not superior to) as conventional exercise program for the rotator cuff tendinopathy in athletes.
Poster 202: Subacromial Decompression is Associated with a Number Needed to Treat of 4 for Reduced Revision Rotator Cuff Repair: A Large Matched Cohort Insurance Database Analysis
Authors: Berlinberg Elyse , Derry Kendall , Patel Harsh , Forlenza Enrico , Mirle Vikranth , Gamsarian Vahram , Mascarenhas Randhir ,   Forsythe Group
Published: August 2023

Objectives: Subacromial decompression (SAD) during arthroscopic rotator cuff repair (ARCR) has traditionally been performed to relieve impingement of the rotator cuff tendons as they pass through the subacromial space. The purpose of this study is to quantify the reduced risk of revision rotator cuff surgery conferred by performing SAD with ARCR. Methods: The PearlDiver administrative claims database was queried for patients who underwent ARCR between 2015-2020 with a minimum follow up of 2 years. The study population was stratified by whether concurrent SAD was performed at the time of the index ARCR. Groups were matched on age, gender, Charlson Comorbidity Index (CCI), complete versus partial tear, and comorbidities previously correlated with RCR healing. The primary outcome was requiring a revision rotator cuff repair. Results: The final analysis included 30,407 patients per group, with a mean age of 60 years (SD=7) and 45.3% women. Baseline demographics were similar between groups after matching. 551 (1.8%) patients without SAD vs. 437 patients with SAD (1.4%) underwent a revision rotator cuff repair, corresponding to a number needed to treat (NNT) of 3.8 (unadj-OR=0.79. 95% CI 0.70-0.90, P<0.001). In a multivariable model, factors associated with revision rotator cuff repair included subacromial decompression (adj- OR=0.79, 95%CI 0.70-0.90, P<0.001), male gender (adj-OR 0.97, 95% CI 0.97-0.98, P=0.017), older age (adj-OR=0.97, 95% CI 0.97-0.98, P<0.001), complete tear (adj-OR=3.62, 95% CI 2.87-4.57, P<0.001), tobacco use (adj-OR 1.33, 95% CI 1.12-1.52, P<0.001), and CCI (adj-OR 1.05, 95% CI 1.01-1.09, P=0.027). Conclusions: In a large cohort of over 60,000 patients with partial or complete rotator cuff tears, performing concurrent SAD conferred a 26% relative risk reduction (NNT»4 patients) for revision rotator cuff repair when compared to ARCR alone. These findings suggest that SAD may reduce the risk of revision rotator cuff surgery. [Table: see text][Table: see text]
Poster 224: Complications Associated with Proximal Hamstring Tendon Repair: A Systematic Review
Authors: Abraham Eliza , Imbergamo Casey , Sequeira Sean , Dreese James , Gould Heath , Lawson Jonathan 
Published: August 2023

Objectives: Proximal hamstring tendon ruptures typically occur as a result of simultaneous hip flexion and knee extension, leading to avulsion of the conjoint and/or semimembranosus tendons from their origin at the ischial tuberosity. Surgical repair of proximal hamstring tendon ruptures has been shown in multiple clinical outcome studies to be superior to nonoperative management, with improved functional scores and ability to return to sport postoperatively. Although several potential complications have been reported in the literature, few studies have comprehensively analyzed the complication profile of proximal hamstring tendon repair. The purpose of this systematic review was to identify the overall rate of complications following proximal hamstring tendon repair, to differentiate these complications into categories, and to compare the complication rates of open versus endoscopic repair. Methods: A systematic review of original research articles was performed using PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. To qualify for study inclusion, included articles were required to be published in English, Level 4 evidence or higher, and had to examine surgical repair of proximal hamstring tendon ruptures. No restrictions were made regarding publication date and methodological quality. Data regarding complications were extracted to calculate the overall complication rate as well as the rate of major and minor complications. A quantitative data synthesis was conducted using Chi-square tests to compare the proportion of patients who experienced complications with endoscopic and open approaches. Results: Forty-three articles including 2,823 proximal hamstring tendon repairs were identified. The overall postoperative complication rate was 15.4% (n = 436). The rate of major complications was 4.6%, including a 0.8% re-rupture rate, 0.8% re-operation rate, 1.7% rate of sciatic nerve injury, 0.9% rate of venous thromboembolism (VTE), and 0.4% rate of deep infection. Minor complications included posterior femoral cutaneous nerve injury (2.4%), persistent sitting pain (2.3%), persistent hamstring myopathy (2.3%), hematoma/seroma (0.8%), peri-incisional numbness (1.8%), and superficial infection (1.1%). Endoscopic proximal hamstring tendon repair was associated with a higher rate of overall complications (p = 0.012), major complications (p = 0.048), and minor complications (p < 0.001) compared to open repair. Conclusions: Proximal hamstring tendon repair is associated with an overall complication rate of 15.4%, including a 4.6% rate of major complications. There was a statistically significant increase in complications for patients treated endoscopically compared to those who underwent an open surgical repair.
Poster 331: ACL Graft Tear or Contralateral ACL Tear: Which is Worse???
Authors: Spindler Kurt , Jin Yuxuan ,   Group MOON Knee, Magnussen Robert 
Published: August 2023

Objectives: Anterior cruciate ligament (ACL) graft tears and contralateral ACL tears are both relatively common following primary ACL reconstruction (ACLR). While some prior studies have combined these injuries as an outcome variable (“subsequent cruciate injury”), there is little prior work comparing the outcomes of these injuries. We hypothesize that patient reported outcome measures (PROMs) and activity level are lower following revision ACLR than following contralateral ACLR. Methods: From a prospective cohort study of 2333 patients who underwent primary, unilateral ACLR, 298 patients were identified who underwent revision ACLR or contralateral ACLR within 5 years of primary ACLR. Following exclusion of 11 patients who had both injuries, 256 patients were eligible for study inclusion, including 124 patients who underwent revision ACLR and 132 patients who underwent contralateral ACLR. Patients were contacted for follow-up at 6 years after the primary ACL reconstruction and PROMs were collected including subjective International Knee Documentation Committee (IKDC) score, Knee Osteoarthritis pain (KOOS-Pain) and knee-related quality of life (KOOS- QOL) subscales, and Marx activity level. Patient demographic and initial injury factors, surgical factors, and PROMs were compared between groups. Multiple regression models were used to determine whether side of subsequent surgery (revision versus contralateral ACLR) was a significant predictor of outcome. Results: Two hundred trenty-three of 256 patients (87%) were contacted and completed PROMs at 6 years following primary ACLR. The median time from primary ACLR to second ACL surgery was lower in the revision group (1.3 years) than the contralateral group (2.0 years, p < 0.001). The revision group also demonstrated a lower incidence of partial lateral meniscectomy and was more likely to have received an allograft for the primary ACLR. There were no significant differences in age, sex, smoking status, pre- operative knee laxity, articular cartilage status at primary ACLR, medial meniscus status at primary ACLR, sport, or pre-operative PROMs between the two groups. At follow-up, the revision ACLR group demonstrated lower Marx activity level and PROMs than the contralateral injury group (Table 1). When controlling for the above factors, the revision ACL group demonstrated a 7.8 point lower IKDC (p<0.001), a 3.2 point lower KOOS-pain (p=0.012), a 10.4 point lower KOOS-QOL (p<0.001), and 2.0 point lower Marx score (p=0.002) than the contralateral ACLR group. Conclusions: Patients who undergo revision ACL R demonstrate with poorer PROMs and lower activity level than those who undergo subsequent revision ACLR. [Table: see text]
Poster 338: Analysis of Patient Reported Outcomes and Subsequent Surgery Rate following Quadriceps Tendon Anterior Cruciate Ligament Reconstruction and Lateral Extra-articular Tenodesis in Skeletally Immature Patients: Two Year Follow-Up
Authors: Perea Sofia Hidalgo , Chipman Danielle , Cordasco Frank , Green Daniel 
Published: August 2023

Objectives: The incidence of anterior cruciate ligament reconstruction (ACLR) in pediatric and adolescent patients is increasing significantly and many patients possess risk factors that predispose to ACL re-tear. Lateral extra-articular tenodesis (LET) may be performed in conjunction with ACLR to reduce the risk of ACL re-tear. The purpose of this study is to evaluate the 2-year clinical outcomes of ACLR with soft tissue quadriceps tendon (QUAD) autograft and a lateral extra-articular tenodesis (LET) using a modified Lemaire technique in skeletally immature patients. Methods: A consecutive series of patients who underwent QUAD tendon autograft ACLR and LET with a minimum of 2-year follow-up data was analyzed retrospectively. ACLR techniques included all- epiphyseal (AE) and complete transphyseal (CT) and were indicated based on skeletal age. Outcome measures included participants’ return to sports (RTS), concomitant or subsequent surgical procedures and multiple patient-reported outcome measures, including Single Assessment Numeric Evaluation (SANE), Pediatric International Knee Documentation Committee (Pedi-IKDC) and HSS Functional Activity Brief Scale (HSS Pedi-FABS) scores. Results: The final cohort included 50 consecutive adolescent patients aged 11 to 16 years (mean 14.2 ± 1 years) with a minimum follow-up of 2 years. Two patients were lost to follow-up. Of the patients included in the study (n=48), 98% participated in high-risk competitive sports (Table 1). Two patients (4%) were revision ACLR. Ten (21%) patients underwent AE and 38 (79%) underwent CT ACLR. Sixteen patients (33%) had subsequent surgical procedures, including 5 contralateral ACLR, 4 meniscus surgeries, 4 QUAD autograft scar revision, 4 irrigation and debridement (2 patients, 2 each) and 3 hardware removal procedures (2 for hemi-epiphysiodesis and 1 tibial socket button removal). The rate of graft failure was 0%. At two-year follow-up, mean SANE score was 93, mean Pedi-IKDC score was 90, and mean HSS-Pedi-FABS score was 23. RTS rate was 100%. Conclusions: A LET when performing an ACLR is safe and should be considered as a concomitant procedure for adolescent patients that are at high risk of re-tear. [Table: see text]
Poster 347: PSYCHOLOGICAL READINESS AFTER REVISION ACL RECONSTRUCTION: A ROAR STUDY
Authors: Milewski Matthew , Coene Ryan , Cook Danielle , Kocher Mininder , Kramer Dennis , Micheli Lyle , Yen Yi-Meng , Christino Melissa , Tarchala Magdalena 
Published: August 2023

Objectives: Background: Revision ACL reconstruction (ACLR) has demonstrated worse functional outcomes and higher reinjury rates in young patients. Psychological associations with revision surgery have not previously been evaluated. Purpose: To investigate levels of psychological readiness and psychological stress in young patients after revision ACLR Methods: Patients, ages 10-35, were enrolled who underwent revision ACLR at one center by one of six surgeons. Psychological readiness and psychological stress was assessed 6-months post- operatively with the Anterior Cruciate Ligament Return to Sport After Injury (ACL-RSI) and PROMIS- Psychological Stress Experiences (PROMIS-PSE), respectively. The International Knee Documentation Committee (IKDC/Pedi-IKDC), and Hospital for Special Surgery Pediatric Functional Activity Scale (HSS Pedi-FABS) were also collected. Patient reported outcomes of revision ACLR patients were compared to a cohort of primary ACLR patients. Propensity score matching 3:1 was performed for age, sex, and graft type. Results: Matching resulted in 81 ACLR patients (57 primary and 24 revision). Mean age in the revision group was 18.6 ± 3.2 (66.7% female). The most common graft type in both the primary and revision group was BTB (65% and 67%, respectively) (Table 1). Mild negative correlation was detected between IKDC and PROMIS PSE (r=-0.31; 95% CI=-0.49, -0.10; p=0.005) and a moderate positive correlation was detected between IKDC and ACL-RSI scores (r=0.56; 95% CI=0.39, 0.70; p<0.001). Revision ACLR patients had lower psychological readiness scores (47 vs. 64, p=0.004) and lower IKDC/Pedi-IKDC scores (72 vs 78, p=0.05), compared to primary ACLR patients. Revision ACLR patients also had longer return to sports clearance compared to primary ACLR (median, 10 months vs 8 months; p=0.02). Regression analysis showed revision patients could expect a 15-point decrease in ACL RSI scores compared to patients who underwent primary ACLR surgery (95% CI=-25.30, -4.21; p=0.007). Furthermore, revision patients also could expect a 1.4 month longer return to sports clearance date compared to primary ACLR patients (95% CI=0.29, 2.60; p=0.01). No differences were noted in Pedi- FABS or PROMIS-PSE scores between revision and primary patients (Table 2). Conclusions: This study is the first to date to examine psychological readiness to return to sport in young patients after revision ACLR. At 6-months post-surgery, revision ACLR patients had lower psychological readiness scores, inferior knee functional outcomes scores, and delayed return to sport clearance. Greater attention to the psychological aspects of recovery in the revision ACLR setting may be important to help optimize post-operative care and outcomes. [Table: see text][Table: see text]
Compositional Shifts and Assembly in Rhizosphere-Associated Fungal Microbiota Throughout the Life Cycle of Japonica Rice Under Increased Nitrogen Fertilization
Authors: Dong Hangyu , Sun Haoyuan , Chen Conglin , Zhang Mingyu , Ma Dianrong 
Published: August 2023

AbstractSoil fungal microbiomes facilitate a range of beneficial functions for their host plants, and rhizosphere fungal community composition, richness, and diversity affect plant growth and development, and crop yield. Therefore, exploring the community structure and assembly of the rhizosphere fungal microbiome and its relationship with soil biochemical properties are fundamental to elucidating how rice plants benefit from their fungal symbionts. In this study, soil samples were collected at seedling, tillering, heading, and ripening stages of rice subjected to three levels of nitrogen fertilization. Plant growth demonstrates a substantial influence on fungal community composition and diversity. From the tillering to the ripening stage, the fungal communities were governed by homogenizing dispersal and dispersal limitation. The prevalence of Glomeromycota, the beneficial fungi, was considerably higher during the heading stage compared to the three other growth stages. This increase in abundance was strongly associated with increased levels of soil nutrients and enhanced activity of nitrogen acquisition enzymes. This may be a strategy developed by rice grown in flooded soil to recruit beneficial fungi in the rhizosphere to meet high nitrogen demands. Our study findings contribute to elucidating the influence of plant development and nitrogen fertilization on the structure and composition of the fungal community as well as its relationship with soil key soil nutrient content and nitrogen-related enzyme activities. They also illustrate how a shift in the fungal community mediates and reflects the effects of nitrogen fertilization input in rice agroecosystems. These findings provide new insights into the effects of changes in nitrogen application in rice rhizosphere at different growth stages on fungal communities and soil biochemical characteristics.