bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multiple courses of steroid pulse therapy are required in treating acquired idiopathic generalized anhidrosis patients with a large anhidrotic area: A retrospective study of 28 cases
Authors: Imafuku Keisuke , Yanagi Teruki , Yoshimoto Norihiro , Miyazawa Hajime , Iwata Hiroaki , Ujiie Hideyuki 
Published: January 2023

Abstract
Patients with acquired idiopathic generalized anhidrosis (AIGA) demonstrate a sudden loss of sweating function without neurological or endocrine abnormalities. The main treatment is steroid pulse therapy. However, the number of courses required for improvement has been unclear. This study aims to clarify the factors associated with AIGA disease severity and with AIGA patients’ responses to steroid pulse therapy. We retrospectively analyzed the clinical information of 28 patients with AIGA at our department from the last 10 years. The median age was 25 years, and the male-to-female ratio was 6:1. The median duration from disease onset to consultation at our department was 9.5 months. Using the Minor test, we found the anhidrosis to be mild in 10 patients, moderate in 2 patients, and severe in 16 patients. Univariate analysis revealed that a history of heat stroke correlated positively and significantly with anhidrotic area score. Steroid pulse therapy was conducted for 18 of the 28 patients (median: two courses) and was effective for every patient who received it. The number of courses also correlated with the anhidrotic area. This retrospective study suggests that patients with a large anhidrotic area need multiple courses of steroid pulse therapy.
Exclusive formula feeding is a potential risk factor for inotrope use in neonatal sepsis. A retrospective cohort study
Authors: Moliner-Calderón Elisenda , Verd Sergio , Leiva Alfonso , Ginovart Gemma , Moll-McCarthy Pia , Figueras-Aloy Josep 
Published: January 2023

Abstract
Background
There is little evidence regarding the outcome of the inotropes accepted for treating neonatal hypotension. Even more, there is no certainty as to whether inotrope properties are beneficial or whether they may be harmful. However, given that the antioxidant content of human milk plays a compensatory role in neonatal sepsis and that human milk feeding has direct effects in modulating the cardiovascular function of sick neonates, this research hypothesized that human milk feeds might predict lower requirements of vasopressors in the management of neonatal septic shock.
Method
Between January 2002 and December 2017, all late preterm and full-term infants attending a neonatal intensive care unit, with clinical and laboratory findings of bacterial or viral sepsis, were identified in a retrospective study. During their first month of life, data on feeding type and early clinical characteristics were collected. A multivariable logistic regression model was constructed to determine the impact of human milk on the use of vasoactive drugs in septic newborns.
Results
322 newborn infants were eligible to participate in this analysis. Exclusively formula-fed infants were more likely to be delivered via C-section, to have a lower birth weight and a lower 1-minute Apgar score than their counterparts. Human milk-fed newborns had 77% (adjusted OR = 0.231;95%CI 0.07 to 0.75) lower odds of receiving vasopressors than exclusively formula-fed newborns.
Conclusion
We report that any human milk feeding is associated with a decrease in the need for vasoactive medications in sepsis-affected newborns. This observation encourages us to undertake further research to determine whether human milk feeds mitigate the use of vasopressors in neonates with sepsis.
Ab-initio investigation of Structural, Opto-Electronic and Thermodynamic properties of ZnAl 2 Se 4 for photovoltaic applications
Authors: Erum Nazia , Ahmad Javed , iqbal Azhar 
Published: February 2023

Abstract
In this manuscript, structural, opto-electronic and thermodynamic properties of ZnAl2Se4 chalcogenide compounds were studied in detail, using Full Potential Linearized Augmented Plane Wave (FP-LAPW) method. The exchange and correlation potentials used in Density Functional Theory (DFT) were calculated using Local Density approximation (LDA), Generalized Gradient Approximation (GGA) method, and modified Becke-Johnson (mBJ) potential using Wien2k code. The obtained results were compared with each other as well as with available experimental data. At ambient conditions ZnAl2Se4 is a direct wide bandgap (Г-Г) semiconductor with bandgap of 2.1eV and 3.3eV with GGA, and mBJ potential respectively. Density of states (TDOS & PDOS) and electron density contour plots was in similar accordance with bandgap showing semiconductive behavior and covalent bonding nature. The optical properties like real as well as imaginary part of dielectric constant, energy loss function L(ω) and conductivity σ(ω) were calculated. Optical aspects show interaction among phonon and electron in terms of long range and short-range forces. The said compound is very useful for various linear–nonlinear optical devices so this compound is very valuable for several linear–nonlinear optical devices. So this manuscript represents comprehensive approach for calculating complete set of useful properties of ZnAl2Se4 compound which can provide support for understanding of various device phenomenon such as electrochemical sensing, photo-voltaic and non-volatile electronic memories.
Development of vocal production in bearded capuchin monkeys: is there space for vocal learning?
Authors: Ferreira Luíza Gonzalez , Izar Patrícia 
Published: January 2023

Abstract

In contrast to language acquisition by humans, in non-human primates vocal production seems independent of learning, with subtle modification related to body growth. Recently, studies showed that changes in the acoustic parameters of some primates calls are influenced by calls of conspecifics. This can be considered a simple form of vocal production learning. In this paper, we investigated the vocal development of bearded capuchin monkeys to understand whether the calls changes along the development and if these modifications are influenced by experience or by body growth alone. Immatures between 1–36 months old were followed and the calls emitted by them were recorded. We analyzed acoustically six vocalizations (CN, chihui, hip, trill, squeal, WS). The six vocalizations did not become more stereotyped over the course of development, but CN, chihui, trill, squeal, and WS had acoustic changes throughout the development. CN and chihui, two low frequency gradual calls, developed faster. The development of chihui was not explained by the body growth and it is possible it develops from CN, another gradual call. CN, trill, squeal and WS had acoustic changes related to body growth. Hip was the only vocalization not explained by the development. This vocalization is emitted in several stressful situations and the acoustic changes could be influenced by internal state of the caller. We conclude vocalizations of bearded capuchin monkeys change with body growth but the acoustic structure and function of the call affect the course of vocal development.
Tracing the Geographical Origin of Vinegar Using the Technology of Elementary Analyzer Isotope Ratio Mass Spectrometers and Chemometrics
Authors: Xiong Cen , Wang Qi 
Published: February 2023

Abstract
Shanxi extra-aged vinegar (SX) and Zhenjiang vinegar (ZJ) are two kinds of well-known vinegar in China, always counterfeited in the market due to their geographical indication labels. The carbon isotope ratio data (δ 13C) measured by elementary analyzer isotope ratio mass spectrometer (EA-IRMS), were used to distinguish two geographical indications of vinegar (SX and ZJ) from other vinegar samples with different producing regions. The δ 13C value data of vinegar, the protein extracted from vinegar, and the sugar extracted from vinegar were measured separately. It was found that using each of the three kinds of δ 13C value as a single parameter to vinegar distinguishment is not practicable. Hence, the linear discriminant analysis (LDA) discriminant analysis model was established for vinegar distinguishment by using all three kinds of δ 13C data as multi-indicators. The results indicated 24 SX and 35 ZJ vinegar samples could be obviously discriminated from the other 26 vinegar samples in this distinguishment model. This data suggested that EA-IRMS coupled with LDA could be used as a further tool for vinegar traceability and geographical indications protection.
Impact of Postinflammatory Hyperpigmentation on Quality of Life in patients of Skin of Color
Authors: Bhattacharya Ipshita , Dsouza Paschal , Dhaka Kanchan 
Published: January 2023

Abstract
BACKGROUND
Dyschromias are the second most diagnosed dermatological entity in patients of Skin-of-Color (SOC). People of SOC develop PIH with a higher frequency and severity attributable to the presence of reactive melanocytes. This can have severe repercussions on self-esteem and social/emotional functioning. While there are studies on impact of post-acne PIH on QOL, assessment of impact of PIH on Quality-of-life as a heterogenous group of dermatoses has not been studied previously.
OBJECTIVES
To assess the impact of PIH on QOL in patients of Skin-of-color using Skindex-16.
MATERIALS AND METHODS
This was a cross-sectional study involving 60 patients of SOC having biopsy-proven PIH from October 2019 to September 2021. Patients underwent thorough clinical workup, Skindex-16 was administered and data was analysed.
RESULTS
The mean age was 32.53 ± 11.73 years. 35(58%) patients were male, against 25(42%) females. Most patients reported with PIH secondary to Papulosquamous disorders (n = 23;38.34%), followed by Acne/Acneiform eruptions (n = 11;18.33%). Mean scores for symptoms, emotions, functioning, and total scores were 0.37 ± 0.51, 2.30 ± 1.13, 2.26 ± 1.40 and 1.64 ± 0.85 respectively. PIH lesions with simultaneous evolution were associated with higher symptoms subscale scores. Tendency of PIH, involvement of exposed sites, higher intensity of PIH, epidermal PIH and lesions accentuating on Wood’s lamp had higher, statistically significant impact on emotions, functioning, and total scores. Our study was limited by the sample size and larger, multicentric, population-based studies are recommended.
Development of Machine Learning Models aiming at Knee Osteoarthritis Diagnosing: an MRI Radiomics Analysis
Authors: CUI Tingrun , LIU Ruilong , XU Jiazheng , XU Chi , LI Zhiyuan , HAO Libo , JING Yang , SHI Yanli , FU Jun , CHEN Jiying 
Published: January 2023

Abstract
Background
To develop and assess the performance of machine learning (ML) models based on magnetic resonance imaging (MRI) radiomics analysis for knee osteoarthritis (KOA) diagnosis.
Methods
This retrospective study analysed 148 consecutive patients (72 with KOA and 76 without) with available MRI image data, where radiomics features were extracted and then filtered. Intraclass correlation coefficient (ICC) was calculated to quantify the reproducibility of features, and a threshold of 0.8 was set. The training and validation cohorts consisted of 117 and 31 cases, respectively. Least absolute shrinkage and selection operator (LASSO) regression method was employed for feature selection. The ML classifiers were Logistic Regression (LR), K-Nearest Neighbor (KNN) and support vector machine (SVM). In each algorithm, ten models derived from all available planes of three joint compartments and their various combinations were respectively constructed for comparative analysis. The performance of classifiers was mainly evaluated and compared by receiver operating characteristic (ROC) analysis.
Results
All models achieved satisfying performances, especially the Final model, where accuracy and area under curve (AUC) of SVM classifier were 0.871, 0.942(0.868-1.000, 95% confidence intervals [CI]) in the validation cohort, and 1.000 and 1.000(1.000–1.000, 95% CI) in the training cohort, respectively.
Conclusion
The MRI radiomics analysis represented promising performance in non-invasive and preoperative KOA diagnosis, especially when considering all available planes of all three compartments of knee joints.
Design and Analysis of a Novel Single-input Multi- output Spatial Petal Tooth Nutation Drive
Authors: ZHU Lili , WANG Guangxin , LI Linjie , DU Jihui 
Published: January 2023

Abstract
Single-input multi-output spatial petal gear is a new type of transmission, which combines the ancient lotus petal structure with the nutation drive principle, has many advantages such as small size, light weight, low noise, high bearing capacity, long life, high reliability, etc. and a broad application prospect, especially suitable for the reducer with high bearing capacity. The purpose of this paper is to clarify the basic structure and transmission principle of spatial petal gear, derive the tooth surface equation and meshing equation, analyze the boundary dimensions according to the meshing characteristics of petal gear. The basic parameters of petal gear are designed and calculated by using Matlab software, the 3D model is established by using Creo software, and the kinematics simulation is analyzed to verify the correctness of the innovative structure. The strength analysis are carried out on the tooth surface by finite element method, where the maximum stress occurs to verify the strength requirements of the gear and the rationality of structural design.
Study on the compositional zoning and evolution of symplectitic coronal in jadeitite
Authors: Xing Yingying 
Published: January 2023

Abstract
Based on the fact that multi-stage fluid activities play an important role in the interaction between jadeitite and symplectitic coronas, the author focuses on the study of the compositional zoning and evolution of the representative in Myanmar jadeitite, as the symplectitic coronas with multi-layer concentric ring metasomatic structure (chromite + uvarovite + kosmochlor) and chromite malcrystalline crystals in the core. The results show that: with the participation of multi-stage Ca, Na and Si rich fluid activities, some minerals in Myanmar jadeitite form symplectitic coronas with concentric rings and multi-layer metasomatic reaction edge structure, and the concentration of Cr and Fe decreases from the core to the peripheral jadeite minerals, the concentration of Si increases obviously. There is almost no Si and Ca in the core of chromite, and the concentration of Si and Ca increases sharply at the rim of the uvarovite reaction mineral. Due to the diffusion of Cr, the edge of jadeite adjacent to the kosmochlor is rich in Cr and poor in Al. The variation of element concentration reveals that the ouvarovite is formed by the interaction between the chromite and the jadeite or the Si of the kosmochlor after the metasomatism, or the external Ca-rich fluid. One possibility of the formation of kosmochlor is the interaction between the chromite and the fluid rich in Na and Si. Another is that the Ca-rich fluid first interacted with the chromite and forms the ouvarovite, leading to the decrease of Ca and increase of Fe and AL, later the Na-rich fluid enters and saturates the kosmochlor, leading to the formation of kosmochlor surrounding the ouvarovite.
The histological and pathological changes of liver and testis of Japanese quails fed different levels of dietary L-valine
Authors: Rashidi Ali , Sharifi Seyed Davood , Alizadeh AliReza , Najafi Abozar 
Published: January 2023

Abstract
While the roles of dietary L-valine (VAL) in body weight gain were reported, reinforcing roles of this BCAA in oxidative stress and the side effects in sensitive organs such as liver and testis is an undertreated issue. This experiment was carried out to investigate the histological changes of liver and testis of Japanese quail fed different levels of dietary VAL. Japanese quail chicks (male and female) were used in a completely randomized design with five experimental groups (five levels of VAL), for 42 days. Experimental diets including 0.75 (Control), 0.85, 0.95, 1.05 and 1.15%VAL in diet were formulated to be isoenergetic and isonitrogenous to meet nutrients recommendation of growing quails. At 42 d of age, quails were slaughtered and tissue samples were collected and fixed to evaluate the histological indices of liver and testis. Increase of VAL in low protein diet (17% crude protein (CP)), increased diameter of liver cell nucleus and liver hepatocytes (P < 0.01) in both male and female. Bile duct hyperplasia was observed in treatment 1.05% VAL, and treatment 1.15% VAL showed mild hepatosteatosis. In 0.75% and 0.85% VAL groups, there was no negative effects on the liver histology. The level of 0.85% VAL in the diet improved reproductive indexes in male (Tubular differentiation index (TDI) and spermatic index (SI); P < 0.05). In conclusion, the use of high levels of VAL (more than 0.85%) in a low protein diet during at 1–42 d of age can lead to histological damage in the liver and testis of quails.
Sixteen Year Analyses of Burned Areas in Iran Based on Provincial Borders and Land Use with the Aim of Prioritizing and Managing Fires: A Case Study
Authors: Manesh Faridoddin Ebrahimi , Piri Khosro , Abdoli Asghar , Tajik Saeed 
Published: February 2023

Abstract
In the present research, the burned area of each province was investigated according to land use in order to manage and prioritize provinces with extent and high-risk burns. The analyses of burned areas in Iran has been fulfilled in Iran for the first time. Following the expansion of agricultural lands around forests, the number of intentional wildfires aiming at reducing forest area has increased. Only 5% of wildfires in the Mediterranean region have a natural origin. In Iran, the financial damage caused by wildfires (apart from spiritual and intangible damages such as woods, bushes, and herbal plants) between 1968 and 2007 has been estimated at about 1.93 million dollars. Therefore, prioritizing and managing fire in natural ecosystems seems to be essential. In the present study, the burned areas of Iran from 2002-03-21 to 2018-03-21 based on land use were obtained from the data available in the Global Wildfire Information System and were categorized by provincial borders. In order to prepare Iran's land use map, related data (MCD12Q1) were obtained from https://www.earthdata.nasa.gov in HDF5 format. The results showed that Khuzestan, Fars, Kermanshah, and Golestan Provinces, respectively had the largest burned areas in the country. Considering that most burned areas of the country have been recorded in agricultural lands, human factors are very influential in increasing the rate of burned areas, and maintaining distance between agricultural lands and native vegetation (fuel) is mandatory.
Revealing a novel and notable interaction in the binding of type II statins to HMG-CoA reductase: Stacked cation–π interaction
Authors: Ahmadi Aliakbar , Ayoubi-Chianeh Mojgan , Kassaee Mohamad Z. , Fattahi Alireza 
Published: February 2023

Abstract
Statins are the well-known therapy for lowering LDL cholesterol. They inhibit 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase by holding an HMG-like moiety (mevalonate structure) as their core structure. Statins can be divided into two classes based on their hydrophobic side structure. Type I statins (viz. mevastatin, simvastatin) encompass a chiral decalin ring, while type II statins (viz. fluvastatin cerivastatin, atorvastatin, rosuvastatin) encompass an achiral pyrrole or pyrimidine ring with 4-fluorophenyl group. Statins primarily use dipole/dipole and hydrogen bonds to bind to the active site of the reductase, focusing on the portion of the active site dominated by lysine 735, arginine 590, aspartic acid 690, serine 684, lysine 691, asparagine 755, lysine 692 and glutamine 559 with minimal explicit incorporation of hydrophobic side structure interactions.
This study has centered on potentially important enzyme-ligand interaction currently not incorporated: stacked cation–π interaction between the guanidinium group of arginine 590 residues in the HMG-CoA reductase active site and 4-fluorophenyl group of the type II statins. The geometry of interaction between these planar groups has been considered based on the X-ray crystallographic structures already available in the protein data bank (PDB) archive. Electronic interaction energies between this residue and statins have been acquired by M06 and MP2 methods. In addition, stacking interaction and hydrogen bonding as two important investigated interactions are verified through prominent analyses: (1) quantum theory of atoms in molecules (QTAIM) analysis; (2) plotting and quantitative molecular surface analyses such as electrostatic potential (ESP) analysis, Hirshfeld surface (HS) and Becke surface (BS) analyses; (3) visual study methods such as noncovalent interaction (NCI), independent gradient model (IGM) analyses; and (4) localized orbital locator integrated pi over plane (LOLIPOP) index. The results indicate the absolute binding energy for type II statins is overall more than for type I statins.
Sequential Stacking Link Prediction Algorithms for Temporal Networks
Authors: He Xie , Ghasemian Amir , Lee Eun , Clauset Aaron , Mucha Peter 
Published: February 2023

Abstract
Link prediction algorithms are indispensable tools in many scientific applications by speeding up network data collection and imputing missing connections. However, in many systems, links change over time and it remains unclear how to optimally exploit such temporal information for link predictions in such networks. Here, we show that many temporal topological features, in addition to having high computational cost, are less accurate in temporal link prediction than sequentially stacked static network features. This sequential stacking link prediction method uses 41 static network features that avoids detailed feature engineering choices and is capable of learning a highly accurate predictive distribution of future connections from historical data. We demonstrate that this algorithm works well for both partially observed and completely unobserved target layers, and achieves near-optimal AUC on two temporal stochastic block models. Finally, we empirically illustrate that stacking multiple predictive methods together further improves performance on 19 real-world temporal networks from different domains.