bluuebunny/crossref_metadata_2025_split huggingface dataset:
In Vivo Strain Patterns in the Achilles Tendon During Dynamic Activities: A Comprehensive Survey of the Literature
Authors: Adam Naomi C. , Smith Colin R. , Herzog Walter , Amis Andrew A. , Arampatzis Adamantios , Taylor William R. 
Published: July 2023

AbstractAchilles’ tendon (AT) injuries such as ruptures and tendinopathies have experienced a dramatic rise in the mid- to older-aged population. Given that the AT plays a key role at all stages of locomotion, unsuccessful rehabilitation after injury often leads to long-term, deleterious health consequences. Understanding healthy in vivo strains as well as the complex muscle–tendon unit interactions will improve access to the underlying aetiology of injuries and how their functionality can be effectively restored post-injury. The goals of this survey of the literature with a systematic search were to provide a benchmark of healthy AT strains measured in vivo during functional activities and identify the sources of variability observed in the results. Two databases were searched, and all articles that provided measured in vivo peak strains or the change in strain with respect to time were included. In total, 107 articles that reported subjects over the age of 18 years with no prior AT injury and measured while performing functional activities such as voluntary contractions, walking, running, jumping, or jump landing were included in this review. In general, unclear anatomical definitions of the sub-tendon and aponeurosis structures have led to considerable confusion in the literature. MRI, ultrasound, and motion capture were the predominant approaches, sometimes coupled with modelling. The measured peak strains increased from 4% to over 10% from contractions, to walking, running, and jumping, in that order. Importantly, measured AT strains were heavily dependent on measurement location, measurement method, measurement protocol, individual AT geometry, and mechanical properties, as well as instantaneous kinematics and kinetics of the studied activity. Through a comprehensive review of approaches and results, this survey of the literature therefore converges to a united terminology of the structures and their common underlying characteristics and presents the state-of-knowledge on their functional strain patterns.
Astrocytic scar restricting glioblastoma via glutamate–MAO-B activity in glioblastoma-microglia assembloid
Authors: Diep Yen N. , Park Hee Jung , Kwon Joon-Ho , Tran Minh , Ko Hae Young , Jo Hanhee , Kim Jisu , Chung Jee-In , Kim Tai Young , Kim Dongwoo , Chang Jong Hee , Kang You Jung , Lee C. Justin , Yun Mijin , Cho Hansang 
Published: July 2023

Abstract

Background
Glial scar formation is a reactive glial response confining injured regions in a central nervous system. However, it remains challenging to identify key factors formulating glial scar in response to glioblastoma (GBM) due to complex glia-GBM crosstalk.

Methods
Here, we constructed an astrocytic scar enclosing GBM in a human assembloid and a mouse xenograft model. GBM spheroids were preformed and then co-cultured with microglia and astrocytes in 3D Matrigel. For the xenograft model, U87-MG cells were subcutaneously injected to the Balb/C nude female mice.

Results
Additional glutamate was released from GBM-microglia assembloid by 3.2-folds compared to GBM alone. The glutamate upregulated astrocytic monoamine oxidase-B (MAO-B) activity and chondroitin sulfate proteoglycans (CSPGs) deposition, forming the astrocytic scar and restricting GBM growth. Attenuating scar formation by the glutamate–MAO-B inhibition increased drug penetration into GBM assembloid, while reducing GBM confinement.

Conclusions
Taken together, our study suggests that astrocytic scar could be a critical modulator in GBM therapeutics.

Graphical Abstract
Surgical management of mandibular and maxillary central giant cell granuloma
Authors: Dogan Enes , Gunaydin Riza Onder 
Published: July 2023

Abstract
Background
Central giant cell granuloma is a benign intraosseous lesion of bone. It frequently affects the head and neck region, particularly the maxillary and mandibular bones. Despite the availability of various nonsurgical treatment options, surgery is still the most effective treatment option for granulomas that do not respond to medical treatment, cause significant bone deformities, or result in extensive bleeding. In this article, we aimed to show the importance of surgery in certain patients by sharing our experience with five patients who were operated on in our clinic.

Case presentation
In this case series, five patients who attended our clinic with central giant cell granuloma disease and underwent surgical treatments were retrospectively evaluated utilizing the hospital database records. Demographic and medical information, symptoms at admission, the results of CT and MRI imaging, pathologic results, previous treatments, and the surgical therapy performed at our clinic were all considered. Surgical procedures were performed in five patients; marginal mandibulectomy in two, segmental mandibulectomy in one, and partial maxillectomy in the other two. The granulation tissues in the cavity were removed using curettage and a diamond burr. Primary suture, secondary healing, palatal obturator repair, and free fibula flap reconstruction techniques were performed.

Conclusions
The objective of surgical therapy for central giant cell granuloma is to remove the mass with appropriate surgery and repair it properly with the least amount of morbidity and risk of recurrence possible.
Performance of a Cell-Free DNA-Based Multi-cancer Detection Test in Individuals Presenting With Symptoms Suspicious for Cancers
Authors: Bryce Alan H. , Thiel David D. , Seiden Michael V. , Richards Donald , Luan Ying , Coignet Marie , Zhang Quan , Zhang Nan , Hubbell Earl , Kurtzman Kathryn N. , Klein Eric A. 
Published: July 2023

PURPOSE A multi-cancer detection test using a targeted methylation assay and machine learning classifiers was validated and optimized for screening in prospective, case-controlled Circulating Cell-free Genome Atlas (ClinicalTrials.gov identifier: NCT02889978 ) substudy 3. Here, we report test performance in a subgroup of participants with symptoms suspicious for cancer to assess the test's ability to potentially facilitate efficient diagnostic evaluation in symptomatic individuals. METHODS We evaluated test performance (sensitivity, specificity, and accuracy of cancer signal origin [CSO] prediction accuracy) in participants with clinically presenting cancers (CPCs) and noncancer with underlying medical conditions and among two subgroups (65 years and older and GI cancers). Overall survival (OS) of participants who had a cancer signal detected/not detected was compared with SEER-based expected survival. RESULTS A total of 2,036 cancer and 1,472 noncancer participants were included. Specificity was high in all noncancer participants (99.5% [95% CI, 98.4 to 99.8]). In participants with CPCs, the overall sensitivity was 64.3% (95% CI, 62.2 to 66.4) and the overall accuracy of CSO prediction in true positives was 90.3%. For GI cancers, the overall sensitivity was 84.1% (95% CI, 80.6 to 87.1). In participants 65 years and older, test performance was similar to that of all participants. Individuals with cancers not detected had a significantly better OS than that expected from SEER ( P < .01). CONCLUSION This test detected a cancer signal with high specificity and CSO prediction accuracy and moderate sensitivity in symptomatic individuals, with especially high performance in participants with GI cancers. The survival analysis implied that the cancers not detected were less clinically aggressive than cancers detected by the test, providing prognostic insights to physicians. This multi-cancer detection test could facilitate efficient workup and stratify cancer risk in symptomatic individuals.
Ceramide compensation by ceramide synthases preserves retinal function and structure in a retinal dystrophy mouse model
Authors: Qian Xinye , Srinivasan Tanmay , He Jessica , Lu Jiaxiong , Jin Yan , Gu Haiwei , Chen Rui 
Published: July 2023

ABSTRACT
Increasing evidence has supported the role of ceramide as a mediator of photoreceptor dysfunction or cell death in ceramide accumulation and deficiency contexts. TLCD3B, a non-canonical ceramide synthase, was previously identified in addition to the six canonical ceramide synthases (CerSs), and the Tlcd3b−/− mouse model exhibited both retinal dysfunction and degeneration. As previous canonical CerS-deficient mouse models failed to display retinal degeneration, the mechanisms of how TLCD3B interacts with CerSs have not been investigated. Additionally, as the ceramide profile of each CerS is distinct, it is unclear whether the overall level or the homeostasis of different ceramide species plays a critical role in photoreceptor degeneration. Interactions between TLCD3B with canonical CerSs expressed in the retina were examined by subretinally injecting recombinant adeno-associated virus 8 vectors containing the Cers2 (rAAV8-CerS2), Cers4 (rAAV8-CerS4) and Cers5 (rAAV8-CerS5) genes. Injection of all three rAAV8-CerS vectors restored retinal functions as indicated by improved electroretinogram responses, but only rAAV8-CerS5 successfully retained retinal morphology in Tlcd3b−/− mice. CerSs and TLCD3B played partially redundant roles. Additionally, rather than acting as an integral entity, different ceramide species had different impacts on retinal cells, suggesting that the maintenance of the overall ceramide profile is critical for retinal function.
Effectiveness of peer-assisted teaching of medical English skills to non-native English-speaking medical students
Authors: Al Shihabi Ahmad , Mardini Heba , Alkhaledi Ahmad N. , Jarad Lana , Jaber Rama , Jaber Ramez , Naoura Sara , Izzat Mohammad Bashar 
Published: July 2023

Background: Peer-assisted learning has been shown to be constructive in numerous aspects of undergraduate medical education. The purpose of this study was to evaluate the effectiveness of peer-assisted teaching of medical English skills to non-native English-speaking students. Methods: A medical English conversation course was conducted at Damascus University by a group of students. Targeted participants were intermediate level fellow students from the same program. A longitudinal study was carried out between 1st to 31st March 2019 to assess changes in self-assessment of English language skills among course participants. Pre- and post-course appraisal involved a review of previous experience with medical English language, a self-assessment of five English language skills, and an objective measurement of medical English knowledge. In addition, participants were requested to respond to a set of statements related to the importance and the usefulness of peer-assisted teaching of medical English skills. Paired-sample Student t-test was used to compare pre- and post-course appraisal results. Results: 42 students attended the course and completed pre- and post-course appraisals in full. Data analyses showed a statistically significant increase in participants’ confidence in speaking medical English in public (p<0.001) and using English in various medical settings (presenting and discussing cases, writing clinical reports, interviewing patients and reading English medical texts). Objective measurements of medical English knowledge confirmed a significant increase in participants’ knowledge of methods of administration of therapeutics, knowledge of human body parts in English and familiarity with English medical abbreviations. Most participants agreed that peer-education was effective in teaching medical English skills to non-native English-speaking students and in increasing their confidence when using English in real-life medical scenarios. Conclusions:The present study highlights the effectiveness of peer-assisted teaching of medical English skills to non-native English-speaking medical students. Further validation is required and should compare the effectiveness of traditional versus peer-assisted teaching approaches.
Knowledge of women and men about human papillomavirus infection, HPV–related diseases and the available vaccine
Authors: Dobko Katarzyna , Frącz Gabriela , Glac Agata , Kuliga Klaudia , Musz Kinga , Sejnowska Natalia , Socha Agnieszka , Surowiec Agata , Śnieżek Kinga , Zając Anna 
Published: July 2023

Introduction: Worldwide, there are over 660 million men and women who are HPV carriers. This virus is responsible for cancer, i.e. cancer of the anal canal, head and neck region, penis and the most common - cervical cancer, whose early stages are completely curable, and in stage IV, the survival rate does not exceed 10%. That is why prevention is so important and vaccinations for both sexes.
Aim: The aim of the study was to check the awareness of society, both women and men and men, on the HPV virus - the way it spreads, the diseases it causes and the possibilities of preventing infection, as of the date of entry into force in Poland of the program of free preventive vaccinations for girls and boys aged 12 and 13.
Material and methods: The study was conducted in the form of an anonymous online survey containing 21 questions. It was attended by 396 adults.
Results: 80% of the population is unaware of how common HPV infection is. 33% of men believe that it occurs 8 times less often than it actually does, and that having an infection protects against another infection. Only 1/5 of women are aware of the risks. Only 15.15% of the respondents know the correlation between cervical cancer and the presence of the virus. 25% of women are not aware of free cytology. Only half of the respondents know about the free HPV vaccination program. 1/3 of people think that only girls should be vaccinated.
Conclusions: Public awareness of HPV is insufficient. Men showed greater knowledge than women, and in general people with offspring had the lowest knowledge. This shows that the information campaign related to preventive vaccinations should be carried out on a much larger scale, as they are the most effective method of protecting both women and men.
Marketplace Scalability and Strategic Use of Platform Investment
Authors: Li Jin , Pisano Gary , Xu Yejia , Zhu Feng 
Published: July 2023

The scalability of a marketplace depends on the operations of the marketplace platform and its sellers’ capacities. In this study, we explore one strategy that a marketplace platform can use to enhance its scalability: providing an ancillary service to sellers. In our model, a platform can choose whether and when to provide this service to sellers and, if so, what prices to charge and which types of sellers to serve. Although such a service helps small sellers, we highlight that the provision of such a service can diminish the incentives of large sellers to make their own investment, thereby reducing their potential output. When the output reduction by large sellers is substantial, the platform may not want to provide the ancillary service, and, even if it does, it may choose to set a price higher than its marginal cost to motivate large sellers to scale. The platform may also choose to strategically delay the provision of the service.This paper was accepted by Hemant Bhargava, information systems.Supplemental Material: The online appendix is available at https://doi.org/10.1287/mnsc.2022.4522 .
Optical switching will innovate intra data center networks [Invited Tutorial]
Authors: Sato Ken-ichi 
Published: July 2023

Reflecting the recent slow-down in Moore’s law and the proliferation of artificial intelligence/machine learning workloads, the performance and energy consumption of networks are becoming barriers in high-performance computing (HPC) and data centers. Optical switches are expected to break these barriers, and indeed their introduction has recently commenced in data centers. This paper discusses how optical switching technologies can innovate future intra data center networks. Hyperscale data centers are much bigger in scale, and network requirements are slightly different from those of HPC. This paper focus on data center networks, since the impact of optical technologies will be more significant in data centers than in HPC. In addition to the scale issue, important metrics to be considered for network design are traffic characteristics and latency, both of which are highlighted in this paper. For hybrid (electrical packet and optical circuit) switching networks, the target latency for the optical circuit switch network (connection setup/teardown time) is shown to be around 10 µs, and the needed technologies are clarified and verified by experiments. The optical switch can simplify the present multi-tier switching network above tier-1 switches into a single tier configuration, which is possible with the development of efficient large port count optical switches. Among the different switching architectures, combining the different dimensions of space and wavelength is shown to be one of the best solutions. Fast switching needs fast device response time. Si photonics devices using Mach–Zehnder interferometers or ring-resonator-based switches and tunable filters are the most promising candidates; they offer cost-effective mass-production and fast operation and so are excellent candidates for the optical switches envisaged. Another critical technology to maximize the benefits of optical switches is a simple and low-latency control mechanism. Different approaches have been suggested as summarized in this work. Among them, harnessing optical switch parallelism is a unique technique that matches recent advances in electrical switch chips. A fast control network is realized by using a fully decentralized and asynchronous control mechanism. A hyperscale data center offers a wide variety of services, and no one system fits all needs. Optimization of parameters is an important task for maximizing the impact of optical switching in different kinds of data centers.
Ge0.92Sn0.08/Ge multi-quantum-well LEDs operated at 2-μm-wavelength on a 12-inch Si substrate
Authors: Wu Shaoteng , Zhang Lin , Wan Rongqiao , Zhou Hao , Lee Kwang Hong , Chen Qimiao , Huang Yi-Chiau , Gong Xiao , Tan Chuan Seng 
Published: July 2023

The development of an efficient group-IV light source that is compatible with the CMOS process remains a significant goal in Si-based photonics. Recently, the GeSn alloy has been identified as a promising candidate for realizing Si-based light sources. However, previous research suffered from a small wafer size, limiting the throughput and yield. To overcome this challenge, we report the successful growth of GeSn/Ge multiple-quantum-well (MQW) p-i-n LEDs on a 12-inch (300-mm) Si substrate. To the best of our knowledge, this represents the first report of semiconductor LEDs grown on such a large substrate. The MQW LED epitaxial layer is deposited on a 12-inch (300-mm) (001)-oriented intrinsic Si substrate using commercial reduced pressure chemical vapor deposition. To mitigate the detrimental effects of threading dislocation densities on luminescence, the GeSn/Ge is grown pseudomorphically. Owing to the high crystal quality and more directness in the bandgap, enhanced electroluminescence (EL) integrated intensity of 27.58 times is demonstrated compared to the Ge LED. The MQW LEDs exhibit EL emission near 2 μm over a wide operating temperature range of 300 to 450 K, indicating high-temperature stability. This work shows that GeSn/Ge MQW emitters are potential group-IV light sources for large-scale manufacturing.
Poor treatment outcome and associated risk factors among patients with isoniazid mono-resistant tuberculosis: A systematic review and meta-analysis
Authors: Alemu Ayinalem , Bitew Zebenay Workneh , Diriba Getu , Seid Getachew , Moga Shewki , Abdella Saro , Gashu Emebet , Eshetu Kirubel , Tollera Getachew , Dangisso Mesay Hailu , Gumi Balako 
Published: July 2023

Background
To date, isoniazid mono-resistant tuberculosis (TB) is becoming an emerging global public health problem. It is associated with poor treatment outcome. Different studies have assessed the treatment outcome of isoniazid mono-resistant TB cases, however, the findings are inconsistent and there is limited global comprehensive report. Thus, this study aimed to assess the poor treatment outcome and its associated risk factors among patients with isoniazid mono-resistant TB.

Methods
Studies that reported the treatment outcomes and associated factors among isoniazid mono-resistant TB were searched from electronic databases and other sources. We used Joana Briggs Institute critical appraisal tool to assess the study’s quality. We assessed publication bias through visual inspection of the funnel plot and confirmed by Egger’s regression test. We used STATA version 17 for statistical analysis.

Results
Among 347 studies identified from the whole search, data were extracted from 25 studies reported from 47 countries. The pooled successful and poor treatment outcomes were 78% (95%CI; 74%-83%) and 22% (95%CI; 17%-26%), respectively. Specifically, complete, cure, treatment failure, mortality, loss to follow-up and relapse rates were 34%(95%CI; 17%-52%), 62% (95%CI; 50%-73%), 5% (95%CI; 3%-7%), 6% (95%CI; 4%-8%), 12% (95%CI; 8%-17%), and 1.7% (95%CI; 0.4%-3.1%), respectively. Higher prevalence of pooled poor treatment outcome was found in the South East Asian Region (estimate; 40%, 95%C; 34%-45%), and African Region (estimate; 33%, 95%CI; 24%-42%). Previous TB treatment (OR; 1.74, 95%CI; 1.15–2.33), having cancer (OR; 3.53, 95%CI; 1.43–5.62), and being initially smear positive (OR; 1.26, 95%CI; 1.08–1.43) were associated with poor treatment outcome. While those patients who took rifampicin in the continuation phase (OR; 0.22, 95%CI; 0.04–0.41), had extrapulmonary TB (OR; 0.70, 95%CI; 0.55–0.85), and took second-line injectable drugs (OR; 0.54, 95%CI; 0.33–0.75) had reduced risk of poor treatment outcome.

Conclusion
Isoniazid mono-resistant TB patients had high poor treatment outcome. Thus, determination of isoniazid resistance pattern for all bacteriologically confirmed TB cases is critical for successful treatment outcome.
PROSPERO registration number: CRD42022372367
Evaluating the administrative performance of sports clubs from the viewpoint of the General Authority for Youth and Sports, Libya
Authors: Al-Nafiru Hassan Muhammad Muhammad , Chortane Sabri Gaied , Amar Imen Ben , Amara Sofiene , Khalifa Riadh 
Published: July 2023

The study aimed to identify the evaluation of the administrative performance of sports clubs from the point of view of the General Authority for Youth and Sports Libya, and to identify the level of knowledge of the study sample evaluation criteria in the areas of administrative performance of sports clubs in Libya, and the study population included two functional categories, namely senior management, middle management and sports offices in the regions of the employees of the General Authority for Youth and Sports previously Ministry of Sports currently, the study sample consisted of (79 ) people. The studied sample of the role of evaluating the administrative performance of sports clubs from the point of view of the General Authority for Youth and Sports came with a moderate degree with an arithmetic average of (3.28). The study recommended the work of time programs to monitor the performance of work within the corridors of the club in all financial, administrative and technical fields, lectures and workshops in all parts of Libya in order to introduce the evaluation and its importance.