bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis of Silolide Dianions via Reduction of Dichlorosiloles: Important Role of the Solvent
Authors: Szathmári Balázs , Fekete Csaba , Kelemen Zsolt , Holczbauer Tamás , Nyulászi László , Kovács Ilona 
Published: July 2023

AbstractThe reduction of 1,1‐dichloro‐2,5‐bistrimethylsilyl‐3,4‐diphenylsilole to silolide dianion by alkali metals was investigated. As previously demonstrated, the outcome of the reaction depends strongly on the applied alkali metal, solvent, reaction conditions, and substituent pattern. We showed that lithium is a powerful reducing agent in THF or DME solvents, the reaction is even faster than the same reaction with sodium. The X‐ray structures of the corresponding dilithio and disodium silolide dianion were investigated, interestingly recrystallization of the dilithio salt results in a coordination polymer. In order to support the synthetic work DFT calculations were performed.
Lipase‐mediated plant oil hydrolysis—Toward a quantitative glycerol recovery for the synthesis of pure allyl alcohol and acrylonitrile
Authors: Melcher Felix , Vogelgsang Ferdinand , Haack Martina , Masri Mahmoud , Ringel Marion , Roth Arne , Garbe Daniel , Brück Thomas 
Published: July 2023

AbstractPlant based triacylglycerides are a sustainable feedstock for the chemical, bioenergy, food and cosmetic sector. While fatty acids conversion has been intensively studied, processes for glycerol valorization have been scarce. In contrast to chemical hydrolysis of plant triacylglycerides enzymatic hydrolysis methods provide a cleaner glycerol stream. This study focuses on the selection of a commercial lipase capable of quantitative hydrolysis of rapeseed‐ and high oleic sunflower oils. Enzymatic process using only water as the reaction medium allows simplified recovery of pure glycerol. Among the six commercial lipase preparations tested, Candida rugosa lipase was identified as the most effective biocatalyst. Catalytic behavior in buffer and pure water was equivalent. Glycerol generated using a washed lipase was recovered by just three purification steps. The FTIR spectrum of the recovered glycerol was equivalent to pure glycerol standard. Over the entire recovery process, 82%–88% of the theoretical glycerol yield could be obtained. Purified glycerol was further didehydroxylated to allyl alcohol by a formic acid mediated open distillation process. The enriched allyl alcohol had a quality, which allows to use it for the synthesis of bio‐based acrylonitrile.
Creating new water‐soluble Iso‐ and n‐fatty acid arginate hydrochloride with antimicrobial properties
Authors: Zhang Jianwei , Huang Kun , Fan Xuetong , Strahan Gary D. , Nuńez Alberto , Sarker Majher I. , Ngo Helen 
Published: July 2023

AbstractTypically, short‐ and long‐chain lipids from oils exhibit different antimicrobial activities and therefore have been used in agriculture and aquaculture, biomedical therapeutic and antibacterial fields. However, these fatty acids have limitations in terms of bioactive efficacy, thermostability and aqueous solubility. In this study, water‐soluble iso‐fatty acid arginate hydrochloride derivatives with antimicrobial properties were produced by introducing branched (iso‐) chain and other linear‐ (n‐) chain fatty acids to the “arginine” amino acid molecule. The two‐step synthetic route was straightforward and provided an efficient 88% and 76% product yields for ethyl n‐oleoyl arginate hydrochloride and ethyl iso‐oleoyl arginate hydrochloride, respectively. ATR‐FT‐IR, NMR, and LC‐MS‐Q‐TOF techniques were used to thoroughly characterize and confirm the products. These arginate products had strong antimicrobial activities against Listeria innucua, a Gram‐positive bacterium with minimum inhibitory concentrations and minimum bactericidal concentrations ranging from 1.8 µg mL−1 to 29.1 µg mL−1. Therefore, the study demonstrated the development of a novel class of antimicrobial compounds from iso‐fatty acids and arginates.
Progress and perspectives of in situ polymerization method for lithium‐based batteries
Authors: Xiao Guanyou , Xu Hao , Bai Chen , Liu Ming , He Yan‐Bing 
Published: July 2023

AbstractThe application of lithium‐based batteries is challenged by the safety issues of leakage and flammability of liquid electrolytes. Polymer electrolytes (PEs) can address issues to promote the practical use of lithium metal batteries. However, the traditional preparation of PEs such as the solution‐casting method requires a complicated preparation process, especially resulting in side solvents evaporation issues. The large thickness of traditional PEs reduces the energy density of the battery and increases the transport bottlenecks of lithium‐ion. Meanwhile, it is difficult to fill the voids of electrodes to achieve good contact between electrolyte and electrode. In situ polymerization appears as a facile method to prepare PEs possessing excellent interfacial compatibility with electrodes. Thus, thin and uniform electrolytes can be obtained. The interfacial impedance can be reduced, and the lithium‐ion transport throughput at the interface can be increased. The typical in situ polymerization process is to implant a precursor solution containing monomers into the cell and then in situ solidify the precursor under specific initiating conditions, and has been widely applied for the preparation of PEs and battery assembly. In this review, we focus on the preparation and application of in situ polymerization method in gel polymer electrolytes, solid polymer electrolytes, and composite polymer electrolytes, in which different kinds of monomers and reactions for in situ polymerization are discussed. In addition, the various compositions and structures of inorganic fillers, and their effects on the electrochemical properties are summarized. Finally, challenges and perspectives for the practical application of in situ polymerization methods in solid‐state lithium‐based batteries are reviewed.
Impact of perioperative characteristics on the recurrence risk and survival of patients with uterine leiomyosarcoma
Authors: Gracia Myriam , Yildirim Yusuf , Macuks Ronalds , Mancari Rosanna , Achimas‐Cadariu Patriciu , Cusine‐Lopez Laura , Novak Zoltan , Dallaku Kastriot , Zapardiel Ignacio ,   SARCUT Study Group
Published: July 2023

AbstractObjectivesTo analyze the impact of perioperative characteristics on the risk of recurrence in patients with uterine leiomyosarcomas.MethodsA sub‐analysis of the SARComa of the UTerus (SARCUT) study, which is a multicentric cross‐sectional pan‐European study that included 390 patients diagnosed with leiomyosarcoma, between 2001 and 2007. Perioperative factors related to risk of recurrence and survival were analyzed.ResultsThe 5‐year and 10‐year disease‐free survivals (DFS) were 46% and 55%, respectively. Overall survival at 5 and 10 years was 34% and 47%, respectively. The most important factors related to global recurrence were the incomplete cytoreduction (hazard ratio [HR] 2.87; 95% confidence interval [CI] 1.91–4.31); performing bilateral adnexectomy (HR 2.71; 95% CI 1.23–5.93); tumor persistence after any treatment (HR 2.38; 95% CI 1.39–4.06); and adjuvant chemotherapy administration (HR 2.55; 95% CI 1.82–3.58) or adjuvant radiotherapy (HR 2.26; 95% CI 1.53–3.32). The major factors significantly associated with pelvic relapse were tumor persistence after any treatment (HR 3.63; 95% CI 1.83–7.20) and adjuvant radiotherapy (HR 2.74; 95% CI 1.44–5.20). Incomplete cytoreduction was the most important factor associated with distant relapse (HR 1.91; 95% CI 1.22–2.97). The most important factors related to overall survival were tumor persistence after any treatment (HR 4.59; 95% CI 2.51–8.40), incomplete cytoreduction (HR 3.68; 95% CI 2.44–5.56), tumor margin involvement (HR 2.41; 95% CI 1.64–3.55) and adjuvant chemotherapy (HR 1.91; 95% CI 1.31–2.78).ConclusionsComplete cytoreduction is the main prognosis factor impacting the DFS and overall survival of patients with uterine leiomyosarcoma. Adjuvant chemotherapy administration was associated with decreased rates of DFS and overall survival. The adjuvant radiotherapy was associated with a higher risk of global recurrence.
MRElastography of the Pancreas: Bowel Preparation and Repeatability Assessment in Pancreatic Cancer Patients and Healthy Controls
Authors: Wassenaar Nienke P.M. , van Schelt Anne‐Sophie , Schrauben Eric M. , Kop Marnix P.M. , Nio C. Yung , Wilmink Johanna W. , Besselink Marc G.H. , van Laarhoven Hanneke W.M. , Stoker Jaap , Nederveen Aart J. , Runge Jurgen H. 
Published: July 2023

BackgroundPancreatic ductal adenocarcinoma (PDAC) stromal viscoelasticity can be measured using MR elastography (MRE). Bowel preparation regimens could affect MRE quality and knowledge on repeatability is crucial for clinical implementation.PurposeTo assess effects of four bowel preparation regimens on MRE quality and to evaluate repeatability and differentiate patients from healthy controls.Study TypeProspective.Population15 controls (41 ± 16 years; 47% female), 16 PDAC patients (one excluded, 66 ± 12 years; 40% female) with 15 age‐/sex‐matched controls (65 ± 11 years; 40% female). Final sample size was 25 controls and 15 PDAC.Field Strength/Sequence3‐T, spin‐echo echo‐planar‐imaging, turbo spin‐echo, and fast field echo gradient‐echo.AssessmentFour different regimens were used: fasting; scopolaminebutyl; drinking 0.5 L water; combination of 0.5 L water and scopolaminebutyl. MRE signal‐to‐noise ratio (SNR) was compared between all regimens. MRE repeatability (test–retest) and differences in shear wave speed (SWS) and phase angle (ϕ) were assessed in PDAC and controls. Regions‐of‐interest were defined for tumor, nontumorous (n = 8) tissue in PDAC, and whole pancreas in controls. Two radiologists delineated tumors twice for evaluation of intraobserver and interobserver variability.Statistical TestsRepeated measures analysis of variance, coefficients of variation (CoVs), Bland–Altman analysis, (un)pairedt‐test, Mann–Whitney U‐test, and Wilcoxon signed‐rank test.P‐value<0.05 was considered statistically significant.ResultsPreparation regimens did not significantly influence MRE‐SNR. Therefore, the least burdensome preparation (fasting only) was continued. CoVs for tumor SWS were: intrasession (12.8%) and intersession (21.7%), and intraobserver (7.9%) and interobserver (10.3%) comparisons. For controls, CoVs were intrasession (4.6%) and intersession (6.4%). Average SWS for tumor, nontumor, and healthy tissue were: 1.74 ± 0.58, 1.38 ± 0.27, and 1.18 ± 0.16 m/sec (ϕ: 1.02 ± 0.17, 0.91 ± 0.07, and 0.85 ± 0.08 rad), respectively. Significant differences were found between all groups, except for ϕ between healthy–nontumor (P = 0.094).Data ConclusionThe proposed bowel preparation regimens may not influence MRE quality. MRE may be able to differentiate between healthy tissue–tumor and tumor–nontumor.Level of Evidence2Technical Efficacy Stage2
Mammal taphonomy from a singular Late Pleistocene debris‐flow tank deposit in northeastern Brazil
Authors: De Andrade Luana Cardoso , Oliveira Édison Vicente , De Araújo Júnior Hermínio Ismael , Barbosa Fernando Henrique De Souza 
Published: July 2023

ABSTRACTAn integrated taphonomic analysis was applied to a tank deposit from the Zabelê Palaeontological Site (ZPS) in northeast Brazil. The unique sedimentological evidence documents the origin of the mammal assemblage via debris flow. Optically stimulated luminescence (OSL) dates put the ZPS in the later Marine Isotope Stage (MIS) 3, which was a time when it was colder and there were fewer trees. The study revealed that the Zabelê's periphery accumulation was the result of the short transport of specimens and their entrainment by debris flow. This hydraulic transport caused the preferential orientation of the bioclasts (north–southwest). Comparisons were made with other Pleistocene tank deposits, suggesting the occurrence of common megamammal taxa. Temporal mixing was evidenced by the long time interval recorded by OSL ages and the co‐occurrence of distinct degrees of fragmentation, weathering, and fossil diagenesis. Permineralization and staining of Fe3+ and Mn colour patterns were identified as fossilization processes with preservation of the original bone hydroxyapatite without substitution. The comparison with other tank deposits revealed common signatures (disarticulated and fragmented with moderate abrasion) and signs of reworking. Finally, the savanna‐adapted herbivore megamammals from ZPS, such as Eremotherium, Notiomastodon, Toxodon, and Glyptotherium, are congruent with the forest decline from MIS 3 to the Last Glacial Maximum.
Topological duality for orthomodular lattices
Authors: McDonald Joseph , Bimbó Katalin 
Published: July 2023

AbstractA class of ordered relational topological spaces is described, which we call orthomodular spaces. Our construction of these spaces involves adding a topology to the class of orthomodular frames introduced by Hartonas, along the lines of Bimbó's topologization of the class of orthoframes employed by Goldblatt in his representation of ortholattices. We then prove that the category of orthomodular lattices and homomorphisms is dually equivalent to the category of orthomodular spaces and certain continuous frame morphisms, which we call continuous weak p‐morphisms. It is well‐known that orthomodular lattices provide an algebraic semantics for the quantum logic . Hence, as an application of our duality, we develop a topological semantics for using orthomodular spaces and prove soundness and completeness.
The entrancing role of dietary polyphenols against the most frequent aging‐associated diseases
Authors: Shah Muhammad Ajmal , Faheem Hafiza Ishmal , Hamid Ayesha , Yousaf Rimsha , Haris Muhammad , Saleem Uzma , Shah Ghulam Mujtaba , Alhasani Reem H. , Althobaiti Norah A. , Alsharif Ifat , Silva Ana Sanches 
Published: July 2023

AbstractAging, a fundamental physiological process influenced by innumerable biological and genetic pathways, is an important driving factor for several aging‐associated disorders like diabetes mellitus, osteoporosis, cancer, and neurodegenerative diseases including Alzheimer's and Parkinson's diseases. In the modern era, the several mechanisms associated with aging have been deeply studied. Treatment and therapeutics for age‐related diseases have also made considerable advances; however, for the effective and long‐lasting treatment, nutritional therapy particularly including dietary polyphenols from the natural origin are endorsed. These dietary polyphenols (e.g., apigenin, baicalin, curcumin, epigallocatechin gallate, kaempferol, quercetin, resveratrol, and theaflavin), and many other phytochemicals target certain molecular, genetic mechanisms. The most common pathways of age‐associated diseases are mitogen‐activated protein kinase, reactive oxygen species production, nuclear factor kappa light chain enhancer of activated B cells signaling pathways, metal chelation, c‐Jun N‐terminal kinase, and inflammation. Polyphenols slow down the course of aging and help in combatting age‐linked disorders. This exemplified in the form of clinical trials on specific dietary polyphenols in various aging‐associated diseases. With this context in mind, this review reveals the new insights to slow down the aging process, and consequently reduce some classic diseases associated with age such as aforementioned, and targeting age‐associated diseases by the activities of dietary polyphenols of natural origin.
Extracorporeal bladder vibration assay enables early detection and recurrence monitoring for bladder cancer
Authors: Cui Junqi , Wang Xia , Lin Jiali , Zou Yun , Wang Hongkang , Jiang Wenyan , Chen Jiajia , Rao Yamin , Xu Bin , Li Long 
Published: July 2023

AbstractCystoscopy is the current gold standard for diagnosing bladder cancer (Bca), but its invasive nature often results in patient discomfort. This study aims to debise a new strategy to enhance BCa detection. We collected data from 30 BCa patients between January and June 2022. We obtained spontaneously voided urine specimens from these patients before and after administering extracorporeal bladder vibration. These specimens underwent routine cytologic examination and fluorescence in situ hybridization (FISH). Furthermore, we conducted a follow‐up 3 months postoperation. We recollected urine specimens before and after extracorporeal bladder vibration, repeating the cytologic examination and FISH. Our findings indicated an increase in the number of exfoliated cells in patients' urine postvibration compared to previbration. The liquid‐based cell staining results showed an increased detection rate of abnormal cells in the urinary sediment of patients with both low and high‐grade urothelial carcinoma postvibration. Similarly, the FISH results revealed an increased detection rate of CEP3 and CEP7 positive cells postvibration. Additionally, 3 months postoperation, we found abnormal cells in the urine of one patient previbration and in three patients postvibration. Further cystoscopic biopsy confirmed that these three patients had developed tumor recurrence. Our study substantiates that the extracorporeal bladder vibration assay significantly enhances BCa detection and the prediction of tumor recurrence. This method is simple, quick, and cost‐effective, making it a promising approach worthy of widespread clinical application.
Load balancing clustering and routing for IoT‐enabled wireless sensor networks
Authors: Singh Shashank , Anand Veena 
Published: July 2023

AbstractInternet of things (IoT) devices are equipped with a number of interconnected sensor nodes that relies on ubiquitous connectivity between sensor devices to optimize information automation processes. Because of the extensive deployments in adverse areas and unsupervised nature of wireless sensor networks (WSNs), energy efficiency is a significant aim in these networks. Network survival time can be extended by optimizing its energy consumption. It has been a complex struggle for researchers to develop energy‐efficient routing protocols in the field of WSNs. Energy consumption, path reliability and Quality of Service (QoS) in WSNs became important factors to be focused on enforcing an efficient routing strategy. A hybrid optimization technique presented in this paper is a combination of fuzzy c‐means and Grey Wolf optimization (GWO) techniques for clustering. The proposed scheme was evaluated on different parameters such as total energy consumed, packet delivery ratio, packet drop rate, throughput, delay, remaining energy and total network lifetime. According to the results of the simulation, the proposed scheme improves energy efficiency and throughput by about 30% and packet delivery ratio and latency by about 10%, compared with existing protocols such as Chemical Reaction Approach based Cluster Formation (CHRA), Hybrid Optimal Based Cluster Formation (HOBCF), GWO‐based clustering (GWO‐C) and Cat Swarm Optimization based Energy‐Efficient Reliable sectoring Scheme with prediction algorithms (P_CSO_EERSS). The study concludes that the protocol suitable for creating IoT monitoring system network lifetime is an important criteria.
An integrative approach for the design of bioactive polycaprolactone‐based scaffold for bone tissue engineering
Authors: Zusmanovitch Itay , Asbi Thabet , Regev Oshrat , Zigdon Giladi Hadar , Bianco‐Peled Havazelet 
Published: July 2023

AbstractTreatment of large bone defects is challenging and requires coordination between cells, cytokines, and mechanical demands. Scaffold for bone tissue engineering should provide mechanical properties and allow cells adherence, proliferation, and osteodifferentiation. The current study aims to create an improved scaffold for bone tissue engineering, which is tailored to meet crucial scaffold requirements for a successive transplant. To achieve this goal, we adopted an integrative approach that considers simultaneously all essential design criteria, including high porosity, a wide range of pore sizes, a hydrophilic and rough surface, and biofunctionalization, for better bioactivity. We choose polycaprolactone (PCL) because of its mechanical stiffness and combined several methodologies to improve PCL bioactivity. The scaffolds were thoroughly characterized and tested in vitro with two cell lines and in vivo, demonstrating enhanced cell adhesion and proliferation onto and inside the scaffold. We demonstrate that our integrative approach has led to high hydrophilicity, high porosity with interconnected pores, stiffness, and improved bioactivity compared with the other studied scaffolds. These new scaffolds serve as a promising platform for bone engineering.
Circularly polarized luminescence in chiral orientationally ordered soft matter systems
Authors: Liu Jiao , Song Zhen‐Peng , Sun Lu‐Yao , Li Bing‐Xiang , Lu Yan‐Qing , Li Quan 
Published: July 2023

AbstractCircularly polarized luminescent (CPL) materials have received significant attention in the field of fundamental science recently. These materials offer substantial advancement of technological applications, such as optical data storage, displays, and quantum communication. Various strategies have been proposed in self‐assembled materials consisting of inorganic, organic, and hybrid systems, particularly in the chiral orientationally ordered soft matter systems (e.g., chiral liquid crystals (LCs) and LC polymers). However, developing scientific approaches to achieve the pronounced and steerable circularly polarized light emission remains challenging. Herein, we present a comprehensive review on the recent development of CPL materials based on chiral LCs, including thermotropic LCs (cholesteric LCs and bent‐core LCs), lyotropic LCs (nanocellulose LCs and polyacetylene‐based LCs), and LC polymers (cholesteric LC‐based polymers, helical nanofibers, and helical network). In addition, the fundamental mechanisms, design principles, and potential applications based on these chiral LCs and LC polymers in soft matter systems are systematically reviewed. This review summarizes with a prospect on the latent challenges, which can strengthen our understanding of the basic principles of CPL in chiral orientationally ordered soft matter systems and provide a new insight into the progress in several fields, such as chemistry, materials science, optics, electronics, and biology.
Investigate, Explore, Create: Incorporating Biographies into the K–8 Classroom Using the Biography Clearinghouse
Authors: Shimek Courtney , Dawes Erika Thulin 
Published: July 2023

AbstractBiographies are one of our best tools for diversifying the curriculum. In this article, we describe The Biography Clearinghouse, a free resource designed to inspire teachers to use high‐quality biographies in their classrooms. We then elaborate on curricular possibilities in K‐8 classrooms. We end with a discussion of the Investigate, Explore, and Create framework established by The Biography Clearinghouse and provide examples of teaching suggestions using two picturebook biographies and a chapter book biography.
Mobile Devices, Connected Objects, and Sensors
Authors: Mondragón-González Sirenia Lizbeth , Burguière Eric , N’diaye Karim 
Published: July 2023

AbstractBrain disorders are a leading cause of global disability. With the increasing global proliferation of smart devices and connected objects, the use of these technologies applied to research and clinical trials for brain disorders has the potential to improve their understanding and create applications aimed at preventing, early diagnosing, monitoring, and creating tailored help for patients. This chapter provides an overview of the data these technologies offer, examples of how the same sensors are applied in different applications across different brain disorders, and the limitations and considerations that should be taken into account when designing a solution using smart devices, connected objects, and sensors.