bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hunger in French Guiana’s Vulnerable Urban Neighborhoods: A Neglected Consequence of COVID-19
Authors: Basurko Celia , Dupart Ophélie , Savy Mathilde , Obert-Marby Camille , Mvogo Alexandra , Gonzalez Adriana , Trepont Aude , Cann Lisa , Boceno Claire , Osei Lindsay , Creton Pierre-Marie , Dufit Valentin , Thelusme Liliane , Adenis Antoine , Van-Melle Astrid , Huber Florence , Nacher Mathieu 
Published: February 2023

Background: In French Guiana, restrictions to control the spread of SARS-CoV-2 were put in place between March 2020 and March 2022. In vulnerable urban neighborhoods, during this period, requests for food assistance increased and fear of hunger overtook fear of being affected by COVID-19. Objective: The objective of this survey was to describe food security during the COVID-19 pandemic in French Guiana and to study the relationship between the socioeconomic conditions of the study households and household hunger. Methods: A multicenter survey was therefore conducted in mobile clinics and fixed structures providing care to at-risk urban populations. In a face-to-face interview, a community health worker asked participants questions about the sociodemographic and economic profile of the household, and about household food security (food consumption score, coping strategies in the face of food shortages, and household hunger index). Two hundred seventy-seven households were recruited in February 2021. Results: According to the household hunger scale, 42.6% of households experienced moderate hunger and 23.8% of households experienced severe hunger in the month preceding the survey. Lack of residence permit, lack of social support, water insecurity, small housing, and lack of access to an urban garden were determinants related to the risk of household hunger. Conclusions: Food insecurity has affected a large majority of the households in this survey, and the immediate consequences for children’s health were already apparent. These results draw attention to a neglected health problem in a socioeconomically vulnerable population during the COVID-19 pandemic.
Longitudinal impact of stressful life events on HIV-related risk and psychosocial problems among MSM in Chennai and Mumbai, India
Authors: Lodge II William , Biello Katie , Thomas Beena , Rawat Shruta , Baruah Dicky , Dange Alpana , Anand Vivek , Swaminathan Soumya , Kumar Senthil , Balu Vinoth , Menon Sunil , O’Cleirigh Conall , Mayer Kenneth H , Safren Steven A , Mimiaga Matthew J 
Published: February 2023

Background Studies show that stressful life events (SLE) (e.g., discrimination, financial problems) can lead to psychosocial problems and exacerbate condomless anal sex (CAS) without protection via pre-exposure prophylaxis (PrEP) among men who have sex with men. However, few studies have examined this relationship among men who have sex with men in India, and none have examined this longitudinally. Methods As a part of an HIV-prevention intervention, 608 MSM from Chennai and Mumbai, India, completed behavioral surveys at baseline, 4, 8, and 12 months. We used longitudinal generalized estimating equations (GEE) modeling to examine the relationship between SLE and its severity and subsequent psychosocial problems, CAS, and history of diagnosed sexually transmitted infection (STI). All models are adjusted for age, sexual identity, intervention arm, human immunodeficiency virus status, and recruitment city. Results The number of SLE and their corresponding perceived impact score remained consistent at each time point. In multivariable GEE models, the number of SLE was predictive of CAS, depression, and harmful drinking. Similarly, the ratio of the impact of SLE was predictive of CAS, depression, and diagnosed STI. However, harmful drinking was not predictive in this model. Conclusions These findings provide evidence that can inform future interventions, which can be used to enhance self-acceptance, coping skills, and other forms of resiliency.
Aripiprazole, brexpiprazole, and cariprazine can affect milk supply: Advice to breastfeeding mothers
Authors: Naughton Sharna , O’Hara Kate , Nelson Jarren , Keightley Philip 
Published: February 2023

Objective We sought to review the effects of Dopamine Receptor Partial Agonist (DRPA) antipsychotic medications on milk supply and breastfeeding. Method Narrative review of selected literature including animal and human data. Results Scant case study evidence suggests that DRPAs may lead to reduced milk supply for some. Conclusions Women taking DRPAs should be advised of the possibility that these may affect milk supply, and reporting should be encouraged to aid future research.
Evaluation of biliary toxicity in patients with hepatic artery infusion pumps
Authors: Elijah Joseph , Schepers Allison J , Krauss John C , McDevitt Rachel L 
Published: February 2023

Purpose Identify risk factors for biliary toxicity in patients with colorectal liver metastases who received floxuridine (FUDR) via a surgically implanted hepatic artery infusion pump (HAIP). Describe the incidence of biliary toxicity and evaluate relevant patterns in the biliary toxicity cohort. Methods A single center, retrospective, case-control study included adult colorectal cancer patients with liver metastases who received at least one cycle of FUDR via a surgically implanted HAIP from 1 January 2017, to 1 October 2021. Patients were excluded if they had incomplete records, cholangiocarcinoma diagnosis, or received concurrent mitomycin and FUDR. Biliary toxicity criteria derived from existing HAIP literature were utilized to determine whether patients experienced biliary toxicity. Multiple variables were compared by univariate statistical analysis between the biliary toxicity and non-biliary toxicity cohorts to identify potential risk factors for development of FUDR-induced biliary toxicity. Results Out of 50 patients who had a HAIP implanted, 39 met the inclusion criteria. Five of the 39 patients (12.7%) included in the analysis met the pre-specified biliary toxicity criteria. No risk factors for biliary toxicity were identified. All five patients who developed biliary toxicity demonstrated elevations in alkaline phosphatase (ALP) prior to meeting the toxicity criteria. Conclusion Biliary toxicity remains a significant and therapy-limiting consequence of FUDR administration. Rising ALP may be an early indicator of subsequent biliary toxicity. Future studies with more patients may identify risk factors that can facilitate risk mitigation strategies.
Handwashing Practices and Associated Factors Among School Children in Kirkos and Akaki Kality Sub-Cities, Addis Ababa, Ethiopia
Authors: Melaku Abayneh , Addis Taffere 
Published: February 2023

Background: Provision of handwashing facilities and proper practices are essential for preventing fecal-oral and acute respiratory infectious diseases. The aim of this study was to assess availability of handwashing facilities and predictors to students’ good hygiene practices in Addis Ababa, Ethiopia. Methods: A mixed-methods study design was conducted in schools of Addis Ababa from January to March 2020 in 384 students, 98 school directors, 6 health clubs, and 6 school administrators. Data were collected using pretested interviewer-administered questionnaires, interview guide, and observational checklists. The quantitative data were entered into EPI Info version 7.2.2.6 and analyzed using SPSS 22.0. A bivariable at P < .2 and multivariable logistic regression analysis at P < .05 for quantitative and thematic analysis for qualitative data were used. Results: Handwashing stations were available in 85 (86.7%) of the schools. However, 16 (16.3%) schools had neither water nor soap near the handwashing facilities while 33 (38.8%) of schools had both. There was no high school that had both soap and water. Approximately one-third (135, 35.2%) of students practiced proper handwashing, among which 89 (65.9%) were from private schools. The handwashing practices were significantly associated with gender (AOR = 2.45, 95% CI: (1.66-3.59)), having trained coordinator (AOR = 2.16, 95% CI: (1.32-2.48)) and health education program (AOR = 2.53, 95% CI: (1.73-3.59)), school ownership (AOR = 0.49, 95% CI: (0.33-0.72)), and training (AOR = 1.74, 95% CI: (1.82-3.69)). Water supply interruption, and lack of budget, adequate space, training, health education, maintenance, and coordination were the main barriers that prevent students from practicing proper handwashing. Conclusions: Handwashing facilities and materials provision and good handwashing practices of students were low. Moreover, providing soap and water for handwashing was insufficient to promote good hygiene practices. There should be regular hygiene education, training, maintenance, and better coordination among stakeholders to create a healthy school environment.
Critical social work in public social services: Poverty-aware organizational practices
Authors: Saar-Heiman Yuval , Nahari Mor , Krumer-Nevo Michal 
Published: February 2023

Summary Whereas some studies have addressed the conditions and practices required to infuse critical notions into the organizational context of public social services, there is a paucity of knowledge on what a critical public service can look like in actual practice. This article explores the possibility of applying critical theory and practice at the organizational level of public social services. It focuses on one social services department in Israel that underwent a six-year process of learning and implementing the Poverty-Aware Paradigm. Findings Based on an in-depth case study that combines ethnographic and participatory methods, we outline how critical ideas are translated to four organizational principles: developing a critical learning culture, acknowledging services users’ knowledge and skills, leading a critical discourse in the community, and poverty-proofing services and allocating resources to tackle poverty. Each of these principles is presented with derivative organizational practices and a detailed account of their implementation. Applications By broadening the framing of critical practice as an individual, street-level endeavor, the findings offer policymakers and public social services professionals an organizational model that mitigates the negative consequences of current neoliberal and managerial policies around the world.
Navigating the coronavirus pandemic 2 years on: Experiences of people with dementia from the British IDEAL cohort
Authors: Dawson Eleanor , Collins Rachel , Pentecost Claire , Stapley Sally , Quinn Catherine , Charlwood Catherine , Victor Christina , Clare Linda 
Published: February 2023

Background and objectives People with dementia have been affected in unique ways during the COVID-19 pandemic. It is not known whether the impact of the pandemic has changed with time or with the changes in social restrictions. This study explored how experiences of coping with the effects of the pandemic in the UK changed over time. Research design and methods We conducted semi-structured interviews with people with dementia living in the community in England and Wales who had taken part in a qualitative interview at an earlier stage of the pandemic. We applied framework analysis to identify themes and compared these with interviewees’ previous accounts. Findings Nine people aged between 51 and 89 years were interviewed; four were female and five had early onset dementia. We identified three themes: 1. Navigating a changing world: Living with coronavirus; 2. A ‘downward spiral’: Managing advancing dementia; and 3. Availability, accessibility, and suitability of support. Findings reflect participants’ ongoing caution about re-emerging from social restrictions to resume valued activities, and how this led to coping behaviours to minimise the impact on wellbeing in the absence of formal support and services. Discussion and implications Despite easing of restrictions across the UK, the negative impact of the coronavirus pandemic on people with dementia continues. Whilst individuals and services have adapted to some of the challenges, there is now an opportunity to rebuild support networks and services to ensure people with dementia are suitably advised, supported and socially engaged to allow them to live as well as possible.
Porous, low thickness carbon-fiber reinforced epoxy composites with excellent flexibility and superior electromagnetic radiation protection
Authors: Tunakova Veronika , Tunak Maros , Novotna Jana 
Published: February 2023

Fiber reinforced polymers, especially carbon fiber reinforced polymers, are expected in the future to contribute more than 50% of the structural mass of an aircraft. With increasing application and experience increased attention is paid to carbon-fiber reinforced composites with improved advanced properties, such as mechanical, structural and electrical, allowing them to displace the more conventional materials, such as metal alloys. In this paper, we used the Design of experiment methodology to investigate the design and properties of newly developed unique porous carbon-fiber reinforced composites intended for electromagnetic shielding purposes. The main goal was therefore to fabricate a composite with low thickness, high permeability to air and water vapor with a satisfactory ability to shield electromagnetic fields, whereas the investigation of the influential variables of the reinforcement and the investigation of the influence of the matrix on the overall shielding efficiency of the composite belongs to the sub-objectives. Furthermore, other important properties of the composites including heat and mass transfer, mechanical and electrical properties were evaluated. A quality index evaluation approach using weighted and normalized data was implemented to choose a composite with properties, which best fits to its intended use. The highest quality index was achieved by the composite containing reinforcement with warp and weft sett 18 dm−1 using carbon tape 2 mm wide. This composite provides electromagnetic shielding 36 dB at 1.5 GHz, having high air permeability 1000 mm/s, relatively low bending rigidity of around 2.5 Nmm and thickness of only 0.37 mm.
Optimal allocation to treatment sequences in individually randomized stepped-wedge designs with attrition
Authors: Moerbeek Mirjam 
Published: February 2023

Background/aims: The stepped-wedge design has been extensively studied in the setting of the cluster randomized trial, but less so for the individually randomized trial. This article derives the optimal allocation of individuals to treatment sequences. The focus is on designs where all individuals start in the control condition and at the beginning of each time period some of them cross over to the intervention, so that at the end of the trial all of them receive the intervention. Methods: The statistical model that takes into account the nesting of repeated measurements within subjects is presented. It is also shown how possible attrition is taken into account. The effect of the intervention is assumed to be sustained so that it does not change after the treatment switch. An exponential decay correlation structure is assumed, implying that the correlation between any two time point decreases with the time lag. Matrix algebra is used to derive the relation between the allocation of units to treatment sequences and the variance of the treatment effect estimator. The optimal allocation is the one that results in smallest variance. Results: Results are presented for three to six treatment sequences. It is shown that the optimal allocation highly depends on the correlation parameter [Formula: see text] and attrition rate [Formula: see text] between any two adjacent time points. The uniform allocation, where each treatment sequence has the same number of individuals, is often not the most efficient. For [Formula: see text] and [Formula: see text], its efficiency relative to the optimal allocation is at least 0.8. It is furthermore shown how a constrained optimal allocation can be derived in case the optimal allocation is not feasible from a practical point of view. Conclusion: This article provides the methodology for designing individually randomized stepped-wedge designs, taking into account the possibility of attrition. As such it helps researchers to plan their trial in an efficient way. To use the methodology, prior estimates of the degree of attrition and intraclass correlation coefficient are needed. It is advocated that researchers clearly report the estimates of these quantities to help facilitate planning future trials.
Efficacy and safety of medical therapies in microscopic colitis: a systematic review and network meta-analysis
Authors: Kumar Aditi , Hiner George , Brookes Matthew J. , Segal Jonathan P. 
Published: February 2023

Background: The mainstay of treatment for microscopic colitis (MC) is budesonide. However, the optimal formulation and dosage of budesonide to induce and maintain remission has not yet been clearly demonstrated. Objectives: To compare the data for efficacy and safety of treatments to induce and maintain remission for MC. Design: We conducted a meta-analysis of randomised controlled trials (RCTs) comparing treatment with each other or placebo for induction and maintenance of clinical and histological remission in MC. Data sources and methods: We searched MEDLINE (1946 to May 2021), EMBASE and EMBASE Classis (1947 to May 2021), the Cochrane central register of controlled trials (Issue 2, May 2021) and conference proceedings between 2006 and 2020. Results were reported as pooled relative risks (RRs) with 95% confidence intervals (CIs) to summarise the effect of each comparison tested, with treatments ranked according to p score. Results: We identified 15 RCTs in total for the treatment of MC. Entocort 9 mg ranked first for clinical (RR: 4.89, CI: 2.43–9.83; p score: 0.86) and histological (RR: 13.39, CI: 1.92–93.44; p score 0.94) induction of remission, whilst VSL#3 ranked second for clinical induction (RR: 5.30, CI: 0.68–41.39; p score 0.81). Budenofalk 6 mg/3 mg alternate day dosing ranked first for clinical maintenance of remission (RR: 3.68, CI: 0.08–159.92, p-score 0.65). Entocort and Budenofalk were associated with the greatest adverse events for induction and maintenance of clinical remission, respectively, although the overall withdrawal numbers for treatment versus placebo groups were 10.9% (22/201) and 10.5% (20/190), respectively. Conclusion: Entocort 9 mg/day ranked first among the treatment options in inducing remission and Budenofalk 6 mg/3 mg alternate day dosing for maintaining remission in the treatment of MC. Moving forward, mechanistic studies exploring the differences between Entocort and Budenofalk would be valuable whilst future RCT studies are needed in non-corticosteroidal maintenance, particularly looking into immunomodulators, biologics and probiotics.
Quality of life with ribociclib versus abemaciclib as first-line treatment of HR+/HER2− advanced breast cancer: a matching-adjusted indirect comparison
Authors: Rugo Hope S. , Harmer Victoria , O’Shaughnessy Joyce , Jhaveri Komal , Tolaney Sara M. , Cardoso Fatima , Bardia Aditya , Maheshwari Vikalp Kumar , Tripathi Sandeep , Haftchenary Sina , Pathak Purnima , Fasching Peter A. 
Published: February 2023

Background: A cyclin-dependent kinase 4/6 inhibitor (CDK4/6i) + endocrine therapy is recommended as first-line treatment for hormone receptor-positive/human epidermal growth factor receptor 2-negative (HR+/HER2−) advanced breast cancer (ABC). Quality of life (QoL) is an important endpoint that affects treatment decisions. Understanding the relevance of CDK4/6i treatment on QoL is gaining importance given use in earlier treatment lines for ABC and an emerging role in treating early breast cancer in which QoL may be more impactful. In the absence of head-to-head trial data, a matching-adjusted indirect comparison (MAIC) permits comparative efficacy between trials. Objective: In this analysis, patient-reported QoL for MONALEESA-2 [ribociclib + aromatase inhibitor (AI)] and MONARCH 3 (abemaciclib + AI) was compared using MAIC with a focus on individual domains. Design: An anchored MAIC of QoL comparing ribociclib + AI versus abemaciclib + AI was performed using data from the European Organization for Research and Treatment of Cancer quality of life questionnaire (QLQ)-C30 and BR-23 questionnaires. Methods: Individual patient data from MONALEESA-2 and published aggregated data from MONARCH 3 were included in this analysis. Time to sustained deterioration (TTSD) was calculated as the time from randomization to a ⩾10-point deterioration with no later improvement above this threshold. Results: Patients from the ribociclib ( n = 205) and placebo ( n = 149) arms of MONALEESA-2 were matched with patients from the abemaciclib ( n = 328) and placebo ( n = 165) arms of MONARCH 3. After weighting, baseline patient characteristics were well balanced. TTSD significantly favored ribociclib versus abemaciclib in appetite loss [hazard ratio (HR), 0.46; 95% confidence interval (CI), 0.27–0.81], diarrhea (HR, 0.42; 95% CI, 0.23–0.79), fatigue (HR, 0.63; 95% CI, 0.41–0.96), and arm symptoms (HR, 0.49; 95% CI, 0.30–0.79). TTSD did not significantly favor abemaciclib compared with ribociclib in any functional or symptom scale of the QLQ-C30 or BR-23 questionnaires. Conclusions: This MAIC indicates that ribociclib + AI is associated with better symptom-related QoL than abemaciclib + AI for postmenopausal patients with HR+/HER2− ABC treated in the first-line setting. Trial registration: NCT01958021 (MONALEESA-2) and NCT02246621 (MONARCH 3)
Interruption of Continuous Glucose Monitoring: Frequency and Adverse Consequences
Authors: Markov Alexander M. , Krutilova Petra , Cedeno Andrea E. , McGill Janet B. , McKee Alexis M. 
Published: February 2023

Background: Removal of diabetes devices, including insulin pumps and continuous glucose monitoring (CGM), is a common practice due to hospital policies, interference with imaging studies, medications, and surgical interventions. Furthermore, these devices are inherently prone to malfunction, adhesive failure, and issues with insertion that can lead to a reduction in wear time. Prescription and dispensing practices provide an exact number of sensors per month without redundancy to account for the realities of daily CGM use. Methods: A RedCap survey was completed by adult patients with type 1 or type 2 diabetes (T1D or T2D) who utilize CGM followed in the Diabetes Center at Washington University in St Louis. Results: Of 384 surveys sent, 99 were completed. Participants had a mean age of 54 years, T1D 69%, female 70%, White 96%, non-Hispanic 96%, and a mean duration of diabetes mellitus (DM) 28 years. Of the cohort, 100% used CGM (80.2% Dexcom, 13.5% Freestyle Libre, 6.3% Medtronic), 61% insulin pump, and 41% Hybrid closed-loop (HCL) systems. CGM-related disruption events included device malfunction (in 85.4% of participants), insertion problems (63.5%), and falling off (61.4%). Medical care–related disruption occurred most frequently in the setting of imaging (41.7%), followed by surgery/procedures (11.7%) and hospitalization (4.4%). Adverse glycemic events attributed to CGM disruption, including hyperglycemia and hypoglycemia, occurred ≥4 times in 36.5% and 12.4% of the cohort, respectively. Conclusions: Disruption in CGM use is common. Lack of redundancy of CGM supplies contributes to care disruption and adverse glycemic events.