bluuebunny/crossref_metadata_2025_split huggingface dataset:
Peer Tutoring
Authors: Haider Salar , Azam Waleed 
Published: March 2023

Peer tutoring is a well-established learning strategy that involvesstudents instructingtheir peers in a systematic way with the goal of enhancing the knowledge and skills of both the tutor and the tutee. A variety of models have been proposed for peer assisted learning. These include but are not limited to class wide peer tutoring, cross age peer tutoring and reciprocal peer tutoring (RPT). These models employ techniquesof grouping individuals together based on differences in expertise, age or specific strengths. In each group, the roles of tutor and tutee are defined. The effectiveness of peer tutoring has been reported by numerousstudies done across variousdisciplines with highly promising results. In order tooptimize the benefits of this strategy, attention must be paid tothe selection and training of tutors, appropriate pairing of individuals, clearly defined objectives and frequent evaluations. Overall, peer tutoring represents a valuable learning methodology when it is appropriately implemented.
This poster was presented at the“Integrated Medical Education Marathon (IMEM) 2017, organized by International Federation of Medical Students Association Pakistan (IFMSA) at the University College of Medicine & Dentistry, Lahore dated February 13th, 2017.
Can Significant Coronary Artery Disease Coexist With Transient Takotsubo Cardiomyopathy, and How Does Spasm Interrelate?
Authors: Angelini Paolo , Uribe Carlo , Salem Philip A. 
Published: March 2023

Abstract
An 86-year-old woman being treated for metastatic breast cancer developed severe chest pain at rest during a follow-up visit at a hospital's outpatient oncology clinic. An electrocardiogram showed severe ST-segment elevation. The patient was given sublingual nitroglycerin and was transferred to the emergency department. Diagnostic coronary angiography revealed moderate coronary artery disease with calcific stenoses and transient spastic occlusion of the left anterior descending coronary artery. For this patient, sublingual nitroglycerin aborted the spastic event and apparent transient takotsubo cardiomyopathy. Chemotherapy can potentially cause endothelial dysfunction and increased coronary spasticity, which could result in takotsubo cardiomyopathy.
Tourist Potential of Ukraine: Challenges and Prospects of the Post-War Time
Authors: LEVYTSKA Inna , KLYMCHUK Alona , SHESTAKOVA Anna 
Published: March 2023

The tourism industry is one of the sectors of the global economy most affected by the pandemic. At the same time, in 2022, having not yet fully recovered from the impact of quarantine restrictions, it was forced to face a completely new challenge for itself - large-scale military operations on a large part of the European territories. It was Ukraine and its tourism sector that suffered the most from the war, and since the prospects for the end of the war are very uncertain, the issue of preserving the country’s tourism potential, finding ways to speed up its recovery and post-war development of the tourism sector of Ukraine are gaining particular relevance.
To substantiate the prospects and challenges for the tourism potential of Ukraine in the post-war period and to determine the key directions of actions of the state and business for its preservation, effective use and expansion during the war period.
The methodological basis of the study was made up of general scientific and special methods of economic theory, in particular, methods of theoretical generalization and comparative analysis and synthesis for the purpose of researching all processes and phenomena of the tourism sector of Ukraine in interdependence and interconnection. In the course of the study, statistical materials of the European Union and Ukraine were applied on the functioning of the tourism sector of the economy and processed using the methods of statistical analysis: comparison, grouping, calculation of average values and proportions, as well as analytical data and assessments of specialized state agencies of Ukraine were used.
A comparison of the impact of the COVID-19 pandemic on the development of the tourism sector of Ukraine and individual EU countries and the shares of tourism trade turnover in their GDP is made, which has revealed to note the low level of use of Ukraine’s own tourism potential in the pre-war period. The key strengths and weaknesses of the tourism sector of Ukraine according to the version of the World Economic Forum have been studied and the prospects and consequences for them as a result of the war have been substantiated. A number of strategic courses of action for the state and business are proposed, based on the main possible prospects for the duration of active hostilities.
The Impact of the COVID-19 Epidemic on Risk Management Perception in Tourism Business
Authors: NINH Nguyen Van 
Published: March 2023

The COVID-19 pandemic is an infectious disease; through the dispersion of steam in the air, the level of rapid global infection, normal control measures have not been effective. Scientists have access to research and publication on the impact of the COVID -19 pandemic. One of the differences in each study depends on the actual population area and habitat of each community in each country. Through this study, it will provide information on the impact relationship of the COVID-19 epidemic in the field of tourism business risk management to have a basis for understanding of tourism risk management response in sustainable tourism recovery and development.
This study is based on behavioral theories, and pathogen stress theories applied extended scales to survey visitors at tourist attractions. The process of collecting data of 487 response and using structural equation modeling to analyze the data.
Research results have verified the impact of the COVID-19 epidemic on risk management issues in tourism business including travel risk and management perception, risk Management places of visitors, awareness of limiting contact when traveling, hygiene and safety awareness, perceived behavioral control, emergency processing support channel.
This research contributes to a better explanation of the behavioral theory framework and helps to better understand the impact of the COVID-19 epidemic in the field of tourism business risk management as well as establish emergency responses for visitors in the future.
Actors, the Actor Network and Their Impact on Public Space Management: Social Network Analysis as a Method
Authors: Lee Dahae 
Published: March 2023

Public space is an essential element of cities as it offers several benefits. Due to its significance, there is much discussion of its design, development and use. Although equally important, the management of public space lacks attention in academia and policy. This is regrettable given concerns about the quality of public space and calls for substantial changes in public space management. Moreover, while multi-actor involvement in public space management has become popular, its impact has been less studied. This paper attempts to fill the research gap by presenting an empirical study on Görlitzer Park in Berlin, Germany. Thereby, it focuses on multi-actor involvement in public space management. Based on the results of social network analysis, the paper provides a valuable insight into the actors involved, the actor network and their impact on public space management. Most importantly, the paper argues that the structure of the actor network matters for managing public space. This suggests that improving the actor network can be a key to enhancing the quality of public space. The paper also discusses how to improve communication between actors to better manage public space.
The Effectiveness of Service Delivery in Fast Moving Consumer Goods Supply Value Chain: A Case Study of Brands Africa Zambia Limited Company
Authors: Kanyamuna Vincent , Chawapiwa Oswell , Bwanga Cynthia 
Published: March 2023

The study focused on analysing the effectiveness of service delivery in fast moving goods supply chains taking Brands Africa as a case study. Some observed supply chain related challenges of Brands Africa that included lower sales volume, high volume of product returns, sale of some expired products out of stock of some product lines and high prices of some merchandise made the study to be mandatory. A pragmatic research paradigm was used in collecting data from a cross-sectional survey sample of 87 respondents and a case study sample of 5 research participants using a survey questionnaire and an in-depth interview guide as research instruments, respectively. The study concluded that supplier contact was strongest on communication with suppliers, importing goods to Zambia and good relationships with suppliers. The study showed Brands Africa had good advertising and merchandising services, and effective marketing research activities in its supply chains The study established that quality of merchandise high, and market image and reputation of Brands Africa was high, and that inventory management, price of merchandise and efficiency of supply chains needed improvement. The study also concluded that there is a significant relationship between supplier contact and marketing contact activities of Brands Africa with the overall satisfaction of its stakeholders. The research recommends Brands Africa to upgrade its product, financial, information and social with its suppliers, transporters, wholesalers and retailers. The study will also guide managers on cost cutting ways, quality management, ensuring efficient operations and maintaining positive image of Brands Africa. The study recommended Brands Africa’s on policy issues like quality of merchandise, quantity of merchandise, price range of merchandise, delivery schedules and communication systems will be improved. The researcher recommends another research to be carried out at national level covering supply chain of other fast-moving consumer goods companies and also considering more independent variables.
Blow-up for compressible Euler system with space-dependent damping in 1-D
Authors: Geng Jinbo , Lai Ning-An , Yuen Manwai , Zhou Jiang 
Published: March 2023

AbstractThis article considers the Cauchy problem for compressible Euler system inR{\bf{R}}with damping, in which the coefficient depends on the space variable. Assuming the initial density has a small perturbation around a constant state and both the small perturbation and the small initial velocity field are compact supported, finite-time blow-up result will be established. This result reveals the fact that if the space-dependent damping coefficient decays fast enough in the far field (belongs toL1(R){L}^{1}\left({\bf{R}})), then the damping is non-effective to the long-time behavior of the solution.
Description and validation of an equilibrium dialysis ID-LC-MS/MS candidate reference measurement procedure for free thyroxine in human serum
Authors: Jansen Heleen I. , van der Steen Rob , Brandt André , Olthaar André J. , Vesper Hubert W. , Shimizu Eri , Heijboer Annemieke C. , Van Uytfanghe Katleen , van Herwaarden Antonius E. 
Published: March 2023

Abstract

Objectives
Free thyroxine (FT4) in serum is routinely measured in clinical practice to diagnose and monitor thyroid disease. Due to its concentration in picomolar range and the delicate equilibrium of free and protein-bound T4, accurate measurement is challenging. As a consequence, large inter-method differences in FT4 results exists. Optimal method design and standardization of the FT4 measurement is therefore necessary. The IFCC Working Group for Standardization of Thyroid Function Tests proposed a reference system with a conventional reference measurement procedure (cRMP) for FT4 in serum. In this study, we describe our FT4 candidate cRMP and its validation in clinical samples.

Methods
This candidate cRMP is based on equilibrium dialysis (ED) combined with determination of T4 with an isotope-dilution liquid chromatography tandem mass-spectrometry (ID-LC-MS/MS) procedure and was developed according to the endorsed conventions. Its accuracy, reliability, and comparability was investigated using human sera.

Results
It was shown that the candidate cRMP adhered to the conventions and its accuracy, precision, and robustness were adequate in serum of healthy volunteers.

Conclusions
Our candidate cRMP measures FT4 accurately and performs well in serum matrix.
A projected homotopy perturbation method for nonlinear inverse problems in Banach spaces
Authors: Xia Yuxin , Han Bo , Wang Wei 
Published: March 2023

Abstract
In this paper, we propose and analyze a projected homotopy perturbation method based on sequential Bregman projections for nonlinear inverse problems in Banach spaces.
To expedite convergence, the approach uses two search directions given by homotopy perturbation iteration, and the new iteration is calculated as the projection of the current iteration onto the intersection of stripes decided by above directions.
The method allows to use

L
1

{L^{1}}

-like penalty terms, which is significant to reconstruct sparsity solutions. Under reasonable conditions, we establish the convergence and regularization properties of the method.
Finally, two parameter identification problems are presented to indicate the effectiveness of capturing the property of the sparsity solutions and the acceleration effect of the proposed method.
Identification of the time-dependent source term in a Kuramoto–Sivashinsky equation
Authors: Cao Kai 
Published: March 2023

Abstract
The determination of an unknown time-dependent source term is investigated in a Kuramoto–Sivashinsky equation from given additional integral-type measurement.
Based on Schauder’s fixed point theorem, the existence and uniqueness of such inverse problem are obtained under certain assumptions on the input data.
In order to calculate the unknown source term, a time-discrete system is established, and its solution shall be applied to approximate the unknown quantity.
The existence, uniqueness and some estimates to the time-discrete system are derived, and the convergence rates are deduced rigorously for both exact and noisy observation, respectively.
Finally, the theoretical convergence rate results are verified, and accurate and stable solutions to the inverse problem are computed numerically by two numerical experiments.
Enhanced heat transfer in corrugated plate fin heat sink
Authors: Jose Alen Mathew , Kumar Manoj , Patil Anil Kumar 
Published: March 2023

Abstract
To design a compact heat sink, a simplified geometry, enhanced heat dissipation, and the minimum pressure drop should be taken into consideration. With this objective, an experimental investigation has been conducted with the corrugated plate-fin heat sink by varying the relative radius of corrugation and relative corrugation pitch in the range of 0.16–0.31, and 0.06–0.16, respectively, for the Reynolds number range of 6000–14,000. Experiments were conducted on a corrugated plate-fin heat sink using an open-loop experimental system comprising a test section of a rectangular channel measuring 2300 mm long, 180 mm wide, and 80 mm high. The corrugated fin creates higher disturbances caused by multiple separations and reattachments in the flow and thereby yielding a higher localized heat transfer coefficient and enhanced heat transfer from the system. The maximum fin performance is found to be 5.87 for the corrugated plate-fin heat sink corresponding to the relative radius of corrugation and relative corrugation pitch of 0.16 and 0.125, respectively.
Chronic hepatitis B complicated with secondary hemochromatosis was cured clinically: A case report
Authors: Ye Yun , Xie Jing , Wang Lina , He Cong , Tan Youwen 
Published: March 2023

Abstract
Chronic hepatitis B (CHB) often causes iron overload in the liver but rarely causes severe secondary hemochromatosis (SH). A 48-year-old man was infected with CHB via vertical transmission. For 21 years, nonstandard treatment with second-line hepatitis B antiviral drugs has been administered. Repeated abnormalities in the liver transaminase function and continuous low-level replication of the hepatitis B virus (HBV) have been detected. The skin had turned black 5 years back. Biochemical tests and imaging revealed the presence of hemochromatosis. A liver biopsy suggested severe iron overload. Two genetic tests ruled out hereditary hemochromatosis. The patient was diagnosed with SH and treated with 400 ml bloodletting once per week and an iron-chelating agent. After 12 weeks, liver function was normal, and the skin turned white. First, hepatitis B surface antigen (HBsAg) was lost, and HBV DNA was copied at low levels. The patient was diagnosed with an occult hepatitis B infection. HBV DNA was undetectable after 4 weeks of antiviral treatment with tenofovir. Upon reviewing the patient’s medical history, hemochromatosis was believed to be related to CHB with chronic inflammatory damage and no complete virological response. Improvements in hemochromatosis may promote HBsAg disappearance.
Blood endothelial ALK1‐BMP4 signaling axis regulates adult hair follicle stem cell activation
Authors: Li Kefei Nina , Chovatiya Gopal , Ko Daniel Youngjoo , Sureshbabu Sripad , Tumbar Tudorita 
Published: March 2023

AbstractBlood vessels can play dual roles in tissue growth by transporting gases and nutrients and by regulating tissue stem cell activity via signaling. Correlative evidence implicates skin endothelial cells (ECs) as signaling niches of hair follicle stem cells (HFSCs), but functional demonstration from gene depletion of signaling molecules in ECs is missing to date. Here, we show that depletion of the vasculature‐factor Alk1 increases BMP4 secretion from ECs, which delays HFSC activation. Furthermore, while previous evidence suggests a lymphatic vessel role in adult HFSC activation possibly through tissue drainage, a blood vessel role has not yet been addressed. Genetic perturbation of the ALK1‐BMP4 axis in all ECs or the lymphatic ECs specifically unveils inhibition of HFSC activation by blood vessels. Our work suggests a broader relevance of blood vessels, adding adult HFSCs to the EC functional repertoire as signaling niches for the adult stem cells.
Brain p3‐Alcβ peptide restores neuronal viability impaired by Alzheimer's amyloid β‐peptide
Authors: Hata Saori , Saito Haruka , Kakiuchi Takeharu , Fukumoto Dai , Yamamoto Shigeyuki , Kasuga Kensaku , Kimura Ayano , Moteki Koichi , Abe Ruriko , Adachi Shungo , Kinoshita Shoich , Yoshizawa‐Kumagaye Kumiko , Nishio Hideki , Saito Takashi , Saido Takaomi C , Yamamoto Tohru , Nishimura Masaki , Taru Hidenori , Sobu Yuriko , Ohba Hiroyuki , Nishiyama Shingo , Harada Norihiro , Ikeuchi Takeshi , Tsukada Hideo , Ouchi Yasuomi , Suzuki Toshiharu 
Published: March 2023

AbstractWe propose a new therapeutic strategy for Alzheimer's disease (AD). Brain peptide p3‐Alcβ37 is generated from the neuronal protein alcadein β through cleavage of γ‐secretase, similar to the generation of amyloid β (Aβ) derived from Aβ‐protein precursor/APP. Neurotoxicity by Aβ oligomers (Aβo) is the prime cause prior to the loss of brain function in AD. We found that p3‐Alcβ37 and its shorter peptide p3‐Alcβ9‐19 enhanced the mitochondrial activity of neurons and protected neurons against Aβo‐induced toxicity. This is due to the suppression of the Aβo‐mediated excessive Ca2+ influx into neurons by p3‐Alcβ. Successful transfer of p3‐Alcβ9‐19 into the brain following peripheral administration improved the mitochondrial viability in the brain of AD mice model, in which the mitochondrial activity is attenuated by increasing the neurotoxic human Aβ42 burden, as revealed through brain PET imaging to monitor mitochondrial function. Because mitochondrial dysfunction is common in the brain of AD patients alongside increased Aβ and reduced p3‐Alcβ37 levels, the administration of p3‐Alcβ9‐19 may be a promising treatment for restoring, protecting, and promoting brain functions in patients with AD.
DETECTION AND GENOTYPE DETERMINATION OF LYMPHOCYSTIS DISEASE VIRUS FROM ORANGE CLOWNFISH Amphiprion percula IN BATAM
Authors: Murwantoko Murwantoko , Wijayanti Endang , Agustatik Sri , Valianti Harshelly , Yulanda Lalla Kumala , Nukmah Nur Lailatul Firotun 
Published: March 2023

The orange clownfish, Amphiprion percula, is a popular fish in the global marine ornamental trade. In March 2021, several orange clown fish at Batam Mariculture Development Center exhibited lethargic behavior with wart-like nodules on the fins suggesting a viral disease infection. This study aimed to detect the suspected viral disease agent from the clownfish and determine its genotype based on the major capsid protein gene. The fish tissues with wart-like nodules were collected and fixed in 96% ethanol. The DNA was extracted from the tissues and used as the template for the amplification of the major capsid protein (MCP) and myristylated membrane protein (MMP) genes using polymerase chain reaction (PCR). The nucleotide sequences of the PCR products were analyzed for their homology using the Basic Local Alignment Search Tool (BLAST). Multiple alignments of the amino acid sequence of MCP were performed using MEGA-X to determine the genotype. The PCR amplification produced the expected bands for detecting MCP, MMP and DNAPol genes. These results indicated the presence of Lymphocystis disease virus (LCDV), designated as LCDV-Oc-Btm. The sequencing of MCP and MMP genes produced the 1221 and 407 nucleotides, respectively. The BLAST analysis showed the highest identity was obtained with the species of LCDV-1 (LCDV-Sa strain) at 91.04 % and 88.19 % for MCP and MMP, respectively. The UPGMA phylogenic tree showed LCDV-Oc-Btm differs from the existing genotype and can be assigned as a new genotype. This study concludes that LCDVOc-Btm is a novel species of lymphocystis disease virus.
EDUCAÇÃO ESTATÍSTICA NO CICLO DE ALFABETIZAÇÃO
Authors: Silva Danielle Gonzaga da , Castro Juscileide Braga de 
Published: March 2023

Esta pesquisa tem por objetivo analisar como as pesquisas teóricas e empíricas desenvolvidas na última década (2012 - 2022), no ciclo de alfabetização (1º e 2º ano), que reforçam ou refutam a proposta da Base Nacional Comum Curricular (BNCC), sobre o Ensino de Estatística. Para isso, foi realizada uma Revisão Sistemática de Literatura, de pesquisas desenvolvidas no Brasil e que foram publicadas em periódicos. Os resultados apontam que mesmo que destacados em documentos norteadores oficiais, nem sempre a proposta de Educação Estatística é implementada de forma a favorecer o protagonismo dos estudantes. Por vezes, ela é limitada à observação passiva de informações compartilhadas, nem sempre referenciadas. Tais pontos chocam com a proposta de favorecer uma análise crítica por parte dos estudantes de dados que são consumidos diariamente. Tais lacunas podem ser agrupadas em três pontos focais: a) ausência de uma formação de professores continuada para trabalhar com conteúdos estatísticos; b) elaboração de materiais didáticos que abordam tais conteúdos de forma “rasa”; c) escassez de pesquisas que evidenciem a defasagem ao tratar sobre ensino-aprendizagem da estatística no Brasil. Destaca-se ainda a relevância de ações resolutivas para os pontos levantados, considerando que, o Ensino da Estatística proporciona o desenvolvimento progressivo de habilidades como pensamento crítico e argumentação com base em fatos, propiciando um trabalho articulado com as competências gerais da BNCC.