bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of SF6 decomposed products by fibre‐enhanced Raman spectroscopy for gas‐insulated switchgear diagnosis
Authors: Wang Jianxin , Chen Weigen , Wang Pinyi , Wan Fu , Zhang Zhixian , Gao Shoufei , Wang Yingying 
Published: August 2023

AbstractSulphur hexafluoride (SF6) decomposed products analysis is highly critical in the early‐stage fault diagnosis of gas‐insulated switchgear (GIS). Spectrum technology outperforms traditional methods on non‐invasiveness, no sample preparation, and no consumption. Here, the authors present an improved fibre‐enhanced Raman spectroscopy (FERS) as a comprehensive analytical tool to detect a suite of SF6 decomposed products (SO2F2, SOF2, SO2, H2S, CF4, OCS, CO2, and CO). The FERS approach is combined with two iris diaphragms for spatial filtering and a rear‐end reflector for additional Raman signal enhancement. Limits of detection down to 1 × 10−6–8 × 10−6 are achieved for different SF6 decompositions, and quantification of an undefined multigas, sampled from an 800 kV GIS in service, is realised utilising SF6 as the internal standard gas and with a maximum error of 5.5 %. The GIS is diagnosed according to the results and confirmed by an on‐site check. The authors foresee that this technique will provide a route for trace gas analysis in the power industry.
Miniaturised element frequency selective surface design for high power microwave applications
Authors: Wu Kai , Xu Wanye , Li Peng , Zhou Jinzhu , Li Weiheng 
Published: August 2023

AbstractA third‐order miniaturised element frequency selective surface (MEFSS) for high‐power microwave (HPM) systems is proposed. The MEFSS design is characterised by the excellent capability to handle high‐power waves and the stable frequency response at large incidence angles. Through combining the particle swarm optimisation algorithm and the equivalent circuit method to improve the efficiency, the design has low resonant temperature while maintaining a low maximum field enhancement factor. A theoretical guide for the selection of substrate parameters in high‐power systems is provided. Instead of being as small as possible, the loss tangent should be properly selected to reach a balance between metal loss and dielectric loss. To the author's best knowledge, it is the first time in‐band low temperature and out‐of‐band high temperature suppression at various incidence angles are realised. The results show that the frequency response remains stable for incident angles up to 60°, and the maximum temperature is reduced from 148°C to 44°C for incident power density of 10 kW/m2. A MEFSS prototype was fabricated, and the transmission coefficients were measured. The full‐wave simulation and measurement results agree well. It has significance to the engineering progress of FSS as radomes for HPM antenna systems.
A robust lp‐norm localization of moving targets in distributed multiple‐input multiple‐output radar with measurement outliers
Authors: Yang Jing , Liu Chengcheng , Huang Jie , Ding Ting , Hu Dexiu , Zhao Chuang 
Published: August 2023

AbstractThe Gaussian noise model and estimators based on least squares (LS) are widely used in target localisation with distributed multiple‐input multiple‐output (MIMO) radar because of their computational efficiency. However, the accuracy of existing LS‐based target localisation algorithms deteriorates sharply in the presence of outliers in the measurements. Thus, a robust solution is developed based on the ‐norm minimisation criterion and iteratively reweighted least squares (IRLS) for locating a moving target with impulse noise using the angle of arrival (AOA), time delay (TD), and Doppler shift (DS) measurements. First, the AOA, TD, and DS measurement noise models are developed based on the α‐stable distribution. Then, the localisation problem is transformed into an ‐norm minimisation problem by linearising the AOA, TD, and DS measurement equations. Finally, the ‐norm minimisation problem is solved using an IRLS method to obtain the target position and estimate the velocity. Moreover, the optimum of the norm order (p) and the Cramér–Rao lower bound for the target position and velocity estimation are derived under α‐stable distributed measurement noise. The simulation results demonstrate that the developed algorithm offers higher accurascy and robustness than the existing ones in the presence of measurement outliers.
The central role of consumer–brand engagement in product and service brand contexts
Authors: Ndhlovu T. , Maree T. 
Published: August 2023

AbstractThis paper examines key relational drivers and brand outcomes of consumer–brand engagement (CBE) in smartphone (product) and social media (service) brand contexts. The study utilised structural equation modelling to analyse data collected from 503 smartphone owners and 491 social media users through online surveys. The findings show that, in both brand contexts, brand trust, self-expressive brand, and brand interactivity influence CBE. Furthermore, CBE positively influences brand evangelism and consumer-based brand equity. The mediating role of CBE is also reported. The findings imply that developing consumer relationship management (CRM) initiatives that generate brand trust, self-expressive brand, and brand interactivity, will lead to consumers having mutually rewarding and interactive relationships with the brand, leading to favourable brand outcomes. The paper contributes theoretically and contextually by testing an S-D logic-informed conceptual model that explains the important role of CBE in interrelating with important relational concepts in two contexts.
Interprofessional collaboration between prescribers, managers, nursing staff and on-site pharmacists within residential aged care facilities: a mixed-methods study
Authors: Batten Miranda , Lewis Joanne , Naunton Mark , Strickland Karen , Kosari Sam 
Published: August 2023

Abstract

Background
A new on-site pharmacist (OSP) intervention within residential aged care facilities (RACFs) is being investigated to help improve medication management. Interprofessional collaboration amongst prescribers, nursing staff and pharmacists is critical to improving RACF medication management.

Objective
To explore the extent of interprofessional collaboration and the nature of the working relationships between OSPs and prescribers, managers and nursing staff.

Methods
A mixed-methods study was undertaken within the context of a 12-month cluster randomised controlled trial. Semi-structured interviews were conducted with data analysed using framework analysis, and a survey based upon the Physician–Pharmacist Collaboration Index (PPCI) was distributed at two time points (T1 at 3 months and T2 at 9 months after OSP commencement) across seven intervention RACFs.

Results
The qualitative data (n = 33 interviews) findings related to the processes supportive of these relationships e.g. on-site proximity, OSP personality and perceived (or beneficial) benefits of OSPs working with health care team members (such as OSPs being trusted and providing reassurance to RACF health care team members). The PPCI survey mean scores at T1 (n = 33) and T2 (n = 19) suggested that OSPs were able to establish positive working relationships at 3 months and that positive relationships also existed at 9 months. The integrated findings suggested that the working relationships between OSPs and health care team members were generally positive.

Conclusions
This study is the first to explore interprofessional collaboration between OSPs and health-care team members in RACFs. The findings suggest that OSPs can positively contribute to interprofessional collaborative care within RACFs.
Preferences for deprescribing antihypertensive medications amongst clinicians, carers and people living with dementia: a discrete choice experiment
Authors: Raghunandan Rakhee , Howard Kirsten , Ilomaki Jenni , Hilmer Sarah N , Gnjidic Danijela , Bell J Simon 
Published: August 2023

Abstract

Background
Optimal management of hypertension in people with dementia may involve deprescribing antihypertensives. Understanding differing treatment priorities is important to enable patient-centred care. This study explored preferences for antihypertensive deprescribing amongst people living with dementia, carers and clinicians.

Methods
Discrete choice experiments (DCEs) are a stated preference survey method, underpinned by economic theory. A DCE was conducted, and respondents completed 12 labelled choice-questions, each presenting a status quo (continuing antihypertensives) and antihypertensive deprescribing option. The questions included six attributes, including pill burden, and event risks for stroke, myocardial infarction, increased blood pressure, cognitive decline, falls.

Results
Overall, 112 respondents (33 carers, 19 people living with dementia, and 60 clinicians) completed the survey. For people with dementia, lower pill burden increased preferences for deprescribing (odds ratio (OR) 1.95, 95% confidence interval (95% CI) 1.08–3.52). Increased stroke risk (for each additional person out of 100 having a stroke) decreased the likelihood of deprescribing for geriatricians (OR 0.71, 95% CI 0.55–0.92) and non-geriatrician clinicians (OR 0.62, 95% CI 0.45–0.86), and carers (OR 0.71, 95% CI 0.58–0.88). Increased myocardial infarction risk decreased preferences for deprescribing for non-geriatricians (OR 0.81, 95% CI 0.69–0.95) and carers (OR 0.84, 95% CI 0.73–0.98). Avoiding cognitive decline increased preferences for deprescribing for geriatricians (OR 1.17, 95% CI 1.03–1.33) and carers (OR 1.27, 95% CI 1.09–1.48). Avoiding falls increased preferences for deprescribing for clinicians (geriatricians (OR 1.20, 95% CI 1.11–1.29); non-geriatricians (OR 1.16, 95% CI 1.07–1.25)). Other attributes did not significantly influence respondent preferences.

Conclusions
Antihypertensive deprescribing preferences differ amongst people with dementia, carers and clinicians. The study emphasises the importance of shared decision-making within the deprescribing process.
Efficacy and Safety Comparative of Sacubitril/Valsartan vs. Olmesartan in the Treatment of hypertension: A Meta-analysis of RCTs
Authors: Han Yongjin , Zhou Ying , Na Jing , Li Fuhang , Sun Yingxian 
Published: August 2023

Abstract

BACKGROUND
Sacubitril/valsartan (LCZ696) is a widely used drug for hypertension in Asia, popular for its efficacy and safety. However, there has been no comprehensive literature review comparing it with olmesartan. This meta-analysis compared the antihypertensive and adverse effects of sacubitril/valsartan and olmesartan.

METHODS
We conducted a comprehensive search of Pubmed, Web of Science, Embase, Cochrane Library, and ClinicalTrials.gov databases to identify eligible randomized controlled trials (RCTs). The data were then analyzed and processed using Revman 5.4 and Stata SE14 software.

RESULTS
Six RCTs with 4,127 patients were identified, showing that LCZ696 had better blood pressure control than olmesartan; mean sitting systolic and diastolic blood pressure, sitting pulse pressure, 24-hour ambulatory systolic blood pressure, and 24-hour ambulatory diastolic blood pressure were significantly decreased with LCZ696 compared with olmesartan. No significant difference between LCZ696 and olmesartan was observed in the occurrence of the majority of adverse events, with a decreased probability of headache in patients with sacubitril/valsartan compared with olmesartan. The subgroup analysis showed treatment with 400 mg/d LCZ696 was better than olmesartan in reducing serious adverse events.

CONCLUSIONS
Sacubitril/valsartan was better than olmesartan in controlling blood pressure in patients with hypertension, with relatively higher safety.
Molecular phylogeny and morphological evolution of the Chinese land snail Cathaica Möllendorff, 1884 (Eupulmonata: Camaenidae) in Shandong Province, China
Authors: Zhang Guoyi , Wade Christopher M 
Published: August 2023

Abstract
Cathaica is a genus of bradybaenid land snails occurring in China and is widespread in Shandong Province. Here we re-describe three species, C. pyrrhozona, C. fasciola and C. leei, and describe two new species, Cathaica fohuiensis Zhang sp. nov. and Cathaica multicostata Zhang sp. nov.. Geometric morphometric analyses demonstrate that C. pyrrhozona, C. fasciola, C. leei and C. fohuiensis are conchologically similar. Based on differences in their genitalia and molecular data, we consider C. pyrrhozona and C. fasciola to be distinct species. This re-establishes C. pyrrhozona as the type species of Cathaica. Cathaica leei can be distinguished based on its plate spiral whorl and wide umbilicus. The new species C. fohuiensis, with a conical shell and expanded vaginal base, can be distinguished from other Cathaica species based on morphological criteria and is robustly supported in the phylogenetic tree. The other new species, C. multicostata, possesses a strongly ribbed discoid shell and exhibits mucous glands that cluster tightly with the vagina. It is robustly supported in the phylogenetic tree and is the sister taxon to the other Cathaica species. Based on morphological characters and our molecular tree, Pliocathaica, represented here by P. buvigneri, P. pulveratricula and P. gansuica, is not monophyletic.
WTP3.1 Histological stage and five-year recurrence/survival in patients who undergo pancreatoduodenectomy for ampullary adenocarcinoma
Authors: Russell Thomas , Labib Peter , Aroori Somaiah ,   RAW Study Collaborators
Published: August 2023

Abstract

Aims
Patients with ampullary adenocarcinoma (AA) may be offered pancreatoduodenectomy (PD) with curative-intent providing they are appropriate surgical candidates. This study aimed to investigate and quantify the relationship between histological T and N stage, and five-year recurrence/survival in this group.

Methods
Data were extracted from the Recurrence After Whipple’s (RAW) study, a retrospective cohort study of PD outcomes (29 centres from 8 countries, n=1484). Patients with AA were grouped by their T stage and N stage, and five-year recurrence/survival rates were compared using Fisher’s exact test.

Results
394 patients (27%) had AA. T1, T2, T3 and T4 disease affected 46 (12%), 131 (33%), 130 (33%), and 86 (22%) patients, respectively (Tx: 1). Five-year recurrence was 11%, 35%, 53% and 65%, respectively. Patients with T3-4 disease (vs T1-2) had significantly higher rates of five-year recurrence (OR: 3.4, 95% CI: 2.2-5.2). Five-year survival was 78%, 65%, 45% and 36% in patients with T1, T2, T3 and T4 disease, respectively. Patients with T1-2 disease (vs T3-4) had significantly higher rates of five-year survival (OR: 3.1, 95% CI: 2.0-4.7). Concerning nodal status, 154 patients (39%) had no lymph node involvement and 239 (61%) had positive regional lymph nodes (could not be assessed in one patient). Patients with N0 disease (vs N1) had lower five-year recurrence (OR: 0.3, 95% CI: 0.2-0.4) and higher five-year survival (OR: 4.5, 95% CI: 2.7-6.6) rates.

Conclusion
In our multicentre study of AA patients who underwent PD, increasing T and N histological stages were found to correlate with increased five-year recurrence and reduced five-year survival rates.
Single-cell RNA-seq and bulk-seq identify RAB17 as a potential regulator of angiogenesis by human dermal microvascular endothelial cells in diabetic foot ulcers
Authors: Du Hengyu , Li Shenghong , Lu Jinqiang , Tang Lingzhi , Jiang Xiao , He Xi , Liang Jiaji , Liao Xuan , Cui Taixing , Huang Yuesheng , Liu Hongwei 
Published: August 2023

AbstractBackgroundAngiogenesis is crucial in diabetic wound healing and is often impaired in diabetic foot ulcers (DFUs). Human dermal microvascular endothelial cells (HDMECs) are vital components in dermal angiogenesis; however, their functional and transcriptomic characteristics in DFU patients are not well understood. This study aimed to comprehensively analyse HDMECs from DFU patients and healthy controls and find the potential regulator of angiogenesis in DFUs.MethodsHDMECs were isolated from skin specimens of DFU patients and healthy controls via magnetic-activated cell sorting. The proliferation, migration and tube-formation abilities of the cells were then compared between the experimental groups. Both bulk RNA sequencing (bulk-seq) and single-cell RNA-seq (scRNA-seq) were used to identify RAB17 as a potential marker of angiogenesis, which was further confirmed via weighted gene co-expression network analysis (WGCNA) and least absolute shrink and selection operator (LASSO) regression. The role of RAB17 in angiogenesis was examined through in vitro and in vivo experiments.ResultsThe isolated HDMECs displayed typical markers of endothelial cells. HDMECs isolated from DFU patients showed considerably impaired tube formation, rather than proliferation or migration, compared to those from healthy controls. Gene set enrichment analysis (GSEA), fGSEA, and gene set variation analysis (GSVA) of bulk-seq and scRNA-seq indicated that angiogenesis was downregulated in DFU-HDMECs. LASSO regression identified two genes, RAB17 and CD200, as characteristic of DFU-HDMECs; additionally, the expression of RAB17 was found to be significantly reduced in DFU-HDMECs compared to that in the HDMECs of healthy controls. Overexpression of RAB17 was found to enhance angiogenesis, the expression of hypoxia inducible factor-1α and vascular endothelial growth factor A, and diabetic wound healing, partially through the mitogen-activated protein kinase/extracellular signal-regulated kinase signalling pathway.ConclusionsOur findings suggest that the impaired angiogenic capacity in DFUs may be related to the dysregulated expression of RAB17 in HDMECs. The identification of RAB17 as a potential molecular target provides a potential avenue for the treatment of impaired angiogenesis in DFUs.
Triphasic production of IFNγ by innate and adaptive lymphocytes following influenza A virus infection
Authors: Finney George E , Hargrave Kerrie E , Pingen Marieke , Purnell Thomas , Todd David , MacDonald Freya , Worrell Julie C , MacLeod Megan K L 
Published: August 2023

Abstract
Interferon gamma (IFNγ) is a potent antiviral cytokine that can be produced by many innate and adaptive immune cells during infection. Currently, our understanding of which cells produce IFNγ and where they are located at different stages of an infection is limited. We have used reporter mice to investigate in vivo expression of Ifnγ mRNA in the lung and secondary lymphoid organs during and following influenza A virus (IAV) infection. We observed a triphasic production of Ifnγ expression. Unconventional T cells and innate lymphoid cells, particularly NK cells, were the dominant producers of early Ifnγ, while CD4 and CD8 T cells were the main producers by day 10 post-infection. Following viral clearance, some memory CD4 and CD8 T cells continued to express Ifnγ in the lungs and draining lymph node. Interestingly, Ifnγ production by lymph node natural killer (NK), NKT, and innate lymphoid type 1 cells also continued to be above naïve levels, suggesting memory-like phenotypes for these cells. Analysis of the localization of Ifnγ+ memory CD4 and CD8 T cells demonstrated that cytokine+ T cells were located near airways and in the lung parenchyma. Following a second IAV challenge, lung IAV-specific CD8 T cells rapidly increased their expression of Ifnγ while CD4 T cells in the draining lymph node increased their Ifnγ response. Together, these data suggest that Ifnγ production fluctuates based on cellular source and location, both of which could impact subsequent immune responses.
Case report of long-term postural tachycardia syndrome in a patient after messenger RNA coronavirus disease-19 vaccination with mRNA-1273
Authors: Reiner Martin F , Schmidt Dörthe , Frischknecht Lukas , Ruschitzka Frank , Duru Firat , Saguner Ardan M 
Published: August 2023

Abstract

Background
Postural tachycardia syndrome (POTS) is characterized by orthostatic intolerance and heart rate increase in an upright position without orthostatic hypotension. It has been described after coronavirus disease-19 (COVID-19) as well as after COVID-19 vaccination.

Case summary
A 54-year-old female patient presented with a 9-months history of severe orthostatic intolerance since COVID-19 vaccination with messenger RNA (mRNA)-1273 (Spikevax, Moderna). Except for diet-controlled coeliac disease, the patient was healthy, had no allergies, and did not take regular medication. Tilt table testing revealed a significant heart rate increase to 168 bpm without orthostatic hypotension accompanied by light-headedness, nausea, and syncope, findings consistent with POTS. Potential underlying causes including anaemia, thyroid dysfunction, adrenal insufficiency, pheochromocytoma, (auto)-immune disease, chronic inflammation as well as neurological causes were ruled out. Echocardiography and cardiac stress magnetic resonance imaging (MRI) did not detect structural or functional heart disease or myocardial ischaemia. Forty-eight-hour-electrocardiogram (ECG) showed no tachycardias other than sinus tachycardia. Finally, genomic analysis did not detect an inherited arrhythmia syndrome. Serologic analysis revealed adequate immune response to mRNA-1273 vaccination without signs of previous severe acute respiratory syndrome-coronavirus-2 infection. While ivabradine was not tolerated and metoprolol extended release only slightly improved symptoms, physical exercise reduced orthostatic intolerance moderately. At a 5-months follow-up, the patient remained dependant on assistance for activities of daily living.

Discussion
The temporal association of POTS with the COVID-19 vaccination in a previously healthy patient and the lack of evidence of an alternative aetiology suggests COVID-19 vaccination is the potential cause of POTS in this patient. To our knowledge, this is the first case reporting severe, long-term, and treatment-refractory POTS following COVID-19 vaccination with mRNA1273.
Perfect storms shape biodiversity in time and space
Authors: Jablonski David , Edie Stewart M 
Published: August 2023

Abstract
Many of the most dramatic patterns in biological diversity are created by “Perfect Storms” —rare combinations of mutually reinforcing factors that push origination, extinction, or diversity accommodation to extremes. These patterns include the strongest diversification events (e.g. the Cambrian Explosion of animal body plans), the proliferation of hyperdiverse clades (e.g. insects, angiosperms), the richest biodiversity hotspots (e.g. the New World Tropical Montane regions and the ocean's greatest diversity pump, the tropical West Pacific), and the most severe extinction events (e.g. the Big Five mass extinctions of the Phanerozoic). Human impacts on the modern biota are also a Perfect Storm, and both mitigation and restoration strategies should be framed accordingly, drawing on biodiversity's responses to multi-driver processes in the geologic past. This approach necessarily weighs contributing factors, identifying their often non-linear and time-dependent interactions, instead of searching for unitary causes.