bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phlebotomy resulting in controlled hypovolemia to prevent blood loss in major hepatic resections (PRICE-2): study protocol for a phase 3 randomized controlled trial
Authors: Martel Guillaume , Lenet Tori , Wherrett Christopher , Carrier François-Martin , Monette Leah , Workneh Aklile , Brousseau Karine , Ruel Monique , Chassé Michaël , Collin Yves , Vandenbroucke-Menu Franck , Hamel-Perreault Élodie , Perreault Michel-Antoine , Park Jeieung , Lim Shirley , Maltais Véronique , Leung Philemon , Gilbert Richard W. D. , Segedi Maja , Abou-Khalil Jad , Bertens Kimberly A. , Balaa Fady K. , Ramsay Tim , Fergusson Dean A. 
Published: January 2023

Abstract
Introduction
Blood loss and red blood cell (RBC) transfusion in liver surgery are areas of concern for surgeons, anesthesiologists, and patients alike. While various methods are employed to reduce surgical blood loss, the evidence base surrounding each intervention is limited. Hypovolemic phlebotomy, the removal of whole blood from the patient without volume replacement during liver transection, has been strongly associated with decreased bleeding and RBC transfusion in observational studies. This trial aims to investigate whether hypovolemic phlebotomy is superior to usual care in reducing RBC transfusions in liver resection.

Methods
This study is a double-blind multicenter randomized controlled trial. Adult patients undergoing major hepatic resections for any indication will be randomly allocated in a 1:1 ratio to either hypovolemic phlebotomy and usual care or usual care alone. Exclusion criteria will be minor resections, preoperative hemoglobin <100g/L, renal insufficiency, and other contraindication to hypovolemic phlebotomy. The primary outcome will be the proportion of patients receiving at least one allogeneic RBC transfusion unit within 30 days of the onset of surgery. Secondary outcomes will include transfusion of other allogeneic blood products, blood loss, morbidity, mortality, and intraoperative physiologic parameters. The surgical team will be blinded to the intervention. Randomization will occur on the morning of surgery. The sample size will comprise 440 patients. Enrolment will occur at four Canadian academic liver surgery centers over a 4-year period. Ethics approval will be obtained at participating sites before enrolment.

Discussion
The results of this randomized control trial will provide high-quality evidence regarding the use of hypovolemic phlebotomy in major liver resection and its effects on RBC transfusion. If proven to be effective, this intervention could become standard of care in liver operations internationally and become incorporated within perioperative patient blood management programs.

Trial registration
ClinicalTrials.gov NCT03651154. Registered on August 29 2018.
On new general inequalities for s-convex functions and their applications
Authors: Yildiz Çetin , Yergöz Büşra , Yergöz Abdulvahit 
Published: January 2023

AbstractIn this work, we established some new general integral inequalities of Hermite–Hadamard type for s-convex functions. To obtain these inequalities, we used the Hölder inequality, power-mean integral inequality, and some generalizations associated with these inequalities. Also we compared some inequalities (e.g., Theorem 6 and Theorem 8). Finally, we gave some applications for special means.
Arthroscopic iliopsoas tenotomy after total hip arthroplasty: safe method for the right patient
Authors: Nikou Sarantos , Lindman Ida , Sigurdsson Arnar , Karlsson Louise , Öhlin Axel , Senorski Eric Hamrin , Sansone Mikael 
Published: January 2023

AbstractPurposeTo evaluate the outcome of arthroscopic treatment for iliopsoas impingement after total hip arthroplasty (THA) 2 years after surgery using patient reported outcomes (PROM).MethodsIn this study 12 patients (13 hips) were included from a local hip arthroscopy registry. Patients completed web‐based PROMs preoperatively and at a minimum of 2 years postoperatively. The PROMs included the International Hip Outcome Tool short version (iHOT‐12), the Copenhagen Hip and Groin Outcome Score (HAGOS), the European Quality of Life‐5 Dimensions Questionnaire (EQ‐5D), the Hip Sports Activity Scale (HSAS) for physical activity level, the Visual Analog Scale (VAS) for overall hip function and a single question regarding overall satisfaction with the surgery.ResultsThe mean age was 64.4 years (±15.1SD), mean body mass index (BMI) was 26.6 (±4.3SD), mean follow‐up time was 49.8 months (±25SD). Comparing PROMs preoperatively with 2‐year follow up showed an improvement for many of the PROMs used. The PROMs scores were iHOT‐12 (24.9 vs 34.5, p = 0.13), HAGOS subscales (symptoms 38.2 vs 54.5, p = 0.05; pain 36 vs 53, p = 0.04; sport 14.1 vs 35.1, p = 0.03; daily activity 31 vs 47.5, p = 0.04; physical activity 21.8 vs 24, p = 0.76; quality of life 24 vs 35, p = 0.03), EQ‐VAS (57.9 vs 58, p = 0.08), EQ‐5D (0.34 vs 0.13, p = 0.07) and VAS for overall hip function (43.1 vs 46.2, p = 0.14). In total, 10 out of the 12 patients (83%) were satisfied with the intervention.ConclusionPatients undergoing surgery for iliopsoas impingement after previous THA showed improved self‐reported hip function where most patients were satisfied with treatment.
Improving the geotechnical properties of a Nigerian termite reworked soil using pretest drying conditions and sawdust ash
Authors: Ale Temitayo Olamide 
Published: January 2023

AbstractThe environments of tropical regions favour the activities and growth of termitaria on soils and woods. The aim of this study is to determine the effect of pretest drying conditions and sawdust ash (SDA) on the strength properties of termite reworked soil for pre and post engineering construction. Twelve disturbed subsoil samples; six termite reworked soil samples and six neighboring residual soils of each of the termite reworked soils were obtained in Akungba Akoko, South-western Nigeria. The termite reworked soil and the surrounding residual soil met the Nigeria requirement of a good sub-grade soil. However, termite reworked soil shows better geotechnical ratings when compared to the surrounding residual soil samples. This result attested to the fact that termites’ activities promote forces of attraction and adhesion among the soil particles. On the addition of sawdust ash to termite reworked soil at 6% of the weight of the soil samples; the geotechnical properties of the termite reworked soils slightly improved. Again, the geotechnical properties of termite reworked soils were considered under varying pretest drying conditions; of air-dried condition as well as conditions obtained by drying the soils at 50°C ± 5, 75°C ± 5 and 110°C ± 5. The index and strength properties of the termite reworked soils improved with increase in pretest drying temperature. Statistical analysis of ANOVA shows that there is no significant statistical difference in the values of the geotechnical parameters of the sampled soils under pretest drying conditions. For Pearson’s correlation, SDA improved soil and pretest drying temperatures for fine contents with CBR and MDD values; the obtained test values of correlation are higher than the critical r value (0.497). Again we reject null hypothesis in favour of the test hypothesis.
Personalised exercise therapy and self-management support for people with multimorbidity: feasibility of the MOBILIZE intervention
Authors: Skou Søren T. , Brødsgaard Rasmus H. , Nyberg Mette , Dideriksen Mette , Bodtger Uffe , Bricca Alessio , Jäger Madalina 
Published: January 2023

AbstractBackgroundExercise therapy is safe and effective in people with single conditions, but the feasibility in people with two or more conditions is unclear. Therefore, the aim was to evaluate the feasibility of exercise therapy and self-management in people with multimorbidity prior to a randomised, controlled trial (RCT).MethodsThis was a mixed-methods feasibility study performed in two general hospitals and one psychiatric hospital. 20 adult patients (8 females; mean age (SD) 67 (6.9)) with at least two long-term conditions and a score of ≥ 3 on Disease Burden Impact Scale for at least one condition (at least moderate limitations of daily activities) and of ≥ 2 for at least one other condition. Patients with unstable health conditions, at risk of serious adverse events (SAE) or with terminal conditions were excluded. Participants received 12 weeks of exercise (18 60-min group-based and 6 home-based sessions) and self-management support (6 90-min group-based sessions) supervised by physiotherapists. Pre-defined progression to RCT criteria were the primary outcomes and included recruitment rate (acceptable 20 participants in 3 months), retention through follow-up (75% retention), compliance (75% complete > 9 of exercise and > 3 self-management sessions), outcome burden (80% do not find outcomes too burdensome), improvement in quality of life (EQ-5D-5L) and function (6-min walk test; ≥ 50% experience clinically relevant improvements) and intervention-related SAEs (No SAEs). Furthermore, a purposeful sample including eleven participants and two facilitators were interviewed about their experiences of participating/facilitating. Qualitative data was analysed using thematic analysis.ResultsRecruitment rate (20 in 49 days), retention (85%), outcome burden (95%), and SAEs (0 related to intervention) were acceptable, while compliance (70%) and improvements (35% in quality of life, 46% in function) were not (amendment needed before proceeding to RCT). The intervention was found acceptable by both participants and physiotherapists with some barriers among participants relating to managing multiple chronic conditions while caring for others or maintaining a job. Physiotherapists expressed a need for additional training.ConclusionsExercise therapy and self-management are feasible in people with multimorbidity. The subsequent RCT, amending the intervention according to progression criteria and feedback, will determine whether the intervention is superior to usual care alone.Trial registrationClinicalTrials.gov registration: NCT04645732Open Science Frameworkhttps://osf.io/qk6yg/
A customized regimen of intravitreal aflibercept for the treatment of choroidal neovascularization secondary to different chorioretinal diseases
Authors: Moussa Magdy , Leila Mahmoud , Ali Mohamed Mayada , Osama Hashem Ahmed 
Published: January 2023

Abstract
Background
To assess the response of CNV secondary to chorioretinal diseases to IVA and to explore the adequate dosing regimen and the long-term results.

Methods
A retrospective study including patients with treatment-naïve active CNV secondary to chorioretinal diseases. All patients received an initial IVA injection followed by a PRN regimen. The main outcome measures were improvement of BCVA, improvement of anatomical morphology and vascularity of the CNV on SS-OCT, and SS-OCTA, respectively, and ocular or systemic complications attributed to IVA.

Results
The study included 17 eyes of 15 patients. Nine patients (60%) were females. The median age was 20 years. The main primary chorioretinal disease was vitelliform macular dystrophy (29%). The mean baseline BCVA was 0.16. The mean follow-up period was 15 months. Final BCVA improved by a mean of 6 lines. The CNV regressed or became inactive in all eyes. The median number of IVA injections was 2. There were no ocular or systemic complications attributed to IVA.

Conclusion
The customized IVA regimen is effective in inducing long-term regression of secondary CNV and in improving BCVA. Multimodal imaging is fundamental in establishing the diagnosis of CNV, and in monitoring its response to IVA.
Intracranial peak pressure as a predictor for perioperative mortality after spontaneous intracerebral hemorrhage evacuation and decompressive craniectomy
Authors: Wang Zhong , Zhang Ruijian , Han Zhitong , Zhang Yisong , Wang Junqing , Wang Bo , Liu Baiyu , Yang Weiran 
Published: January 2023

Abstract

Background
An optimal intracranial pressure (ICP) management target is not well defined in patients with spontaneous intracerebral hemorrhage. The aim of this study was to explore the association between perioperative ICP monitoring parameters and mortality of patients with spontaneous intracerebral hematoma undergoing emergency hematoma removal and decompressive craniectomy (DC), to provide evidence for a target-oriented ICP management.

Methods
The clinical and radiological features of 176 consecutive patients with spontaneous intracerebral hemorrhage that underwent emergent hematoma evacuation and DC were reviewed. The Glasgow Coma Scale (GCS) and Glasgow Outcome Scale (GOS) scores were assessed 2 weeks after surgery. Multivariate logistic regression analysis was performed to identify predictors for perioperative death.

Results
Forty-four cases (25.0%) were assigned to the ICP group. In patients with an ICP monitor, the median peak ICP value was 25.5 mmHg; 50% of them had a peak ICP value of more than 25 mmHg. The median duration of ICP > 25 mmHg was 2 days. Without a target-specific ICP management, the mortality at 2 weeks after surgery was similar between patients with or without an ICP monitor (27.3% versus 18.2%, p = 0.20). In multivariable analysis, the peak ICP value (OR 1.11, 95% CI 1.004–1.234, p = 0.04) was significantly associated with perioperative death in the ICP group. The area under ROC curve of peak ICP value was 0.78 (95%CI 0.62–0.94) for predicting mortality, with a cut-off value of 31 mmHg.

Conclusion
Compared with a persistent hyperintracranial pressure, a high ICP peak value might provide a better prediction for the mortality of patients with spontaneous intracerebral hemorrhage evacuation and DC, suggesting a tailored ICP management protocol to decrease ICP peak value.
Developing a hybrid algorithm to detect brain tumors from MRI images
Authors: Saad Ghada , Suliman Ali , Bitar Luna , Bshara Shady 
Published: January 2023

Abstract
Background
Image processing technologies have been developed in the past two decades to help clinicians diagnose tumors using medical images. Computer-aided diagnosis systems (CADs) have proven their ability to increase clinicians' detection rate of positive cases by 10% and have become integrated with many medical imaging systems and technologies. The study aimed to develop a hybrid algorithm to help doctors detect brain tumors from magnetic resonance imaging images.

Results
We were able to reach a detection accuracy of 96.6% and design a computer application that allows the user to enter the image and identify the location of the tumor in it if it exists with many additional features.

Conclusions
This approach can be improved by using different segmentation techniques, extracting additional features, or using other classifiers.
Cognitive versus emotional modulation within a Stroop paradigm in patients with schizophrenia
Authors: Romero-Ferreiro Verónica , García-Gutiérrez Ana , Torio Iosune , Marí-Beffa Paloma , Rodríguez-Gómez Pablo , Periáñez José A. , Moreno Eva M. , Romero Carmen , Alvarez-Mon Miguel Ángel , Rodriguez-Jimenez Roberto 
Published: January 2023

Background
Schizophrenia is a complex disorder involving deficits in both cognitive and emotional processes. Specifically, a marked deficit in cognitive control has been found, which seems to increase when dealing with emotional information.

Aims
With the aim of exploring the possible common links behind cognitive and emotional deficits, two versions of the emotional Stroop task were administered.

Method
In the cognitive-emotional task, participants had to name the ink colour (while ignoring the meaning) of emotional words. In contrast, the emotional-emotional task consisted of emotional words superimposed on emotional faces, and the participants had to indicate the emotional valence of the faces. Fifty-eight participants (29 in-patients diagnosed with schizophrenia and 29 controls) took part in the study.

Results
Patients and controls showed similar response times in the cognitive-emotional task; however, patients were significantly slower than controls in the emotional-emotional task. This result supports the idea that patients show a more pronounced impairment in conflict modulation with emotional content. Besides, no significant correlations between the tasks and positive or negative symptoms were found. This would indicate that deficits are relatively independent of the clinical status of patients. However, a significant correlation between the emotional-emotional task and cognitive symptoms was found.

Conclusions
These findings suggest a restricted capacity of patients with schizophrenia to deal with the attentional demands arising from emotional stimuli.
Lie group analysis and novel solutions for the generalized variable-coefficients Sawada-Kotera equation
Authors: El-Shiekh Rehab M. , Gaballah Mahmoud 
Published: January 2023

Abstract
In this paper, the generalized fifth-order variable-coefficients Sawada-Kotera equation arising in coastal seas, fjords, lakes, and the atmospheric boundary layer is studied by using the symmetry method. As a result, four-vector fields are obtained and a commutative Lie group of transformations. Then, by using suitable combinations of the Lie vector fields three distinct similarity reductions in the form of nonlinear ordinary differential equations are yielded. By solving the reduced equations using the known techniques and the Jacobi expansion method many novel periodic and solitary wave solutions are considered. From a physical point of view, the dynamic behavior of two distinct wave structures, periodic and kink soliton, was investigated for different choices of the variable coefficients and it was clear that the wave propagation shape is affected by the change of the variable function.
Παράγοντες που επιδρούν στην πρόθεση των εργαζομένων να εργαστούν με τηλεργασία
Authors: Κούλα Ανθούλα Μ. , Ζαμπετάκης Λεωνίδας Α. 
Published: January 2023

Στην παρούσα έρευνα χρησιμοποιήθηκε μία παραλλαγή της μεθόδου της βινιέτας προκειμένου να διερευνηθεί η πρόθεση των Ελλήνων εργαζομένων να εργαστούν με τηλεργασία σε δύο συνθήκες, με μερική (η εργασία πραγματοποιείται με διάσπαση της ανάμεσα στον φυσικό εργασιακό χώρο του εργαζομένου και εκτός αυτού και σε εργασιακούς χρόνους της επιλογής του) και πλήρη απασχόληση (καθολική πραγματοποίηση της εργασίας εκτός του φυσικού εργασιακού χώρου του εργαζομένου και καθ’ όλη την διάρκεια του εργασιακού του ωραρίου). Συγκεριμένα εξετάστηκε η αντιλαμβανόμενη επίδραση πέντε παραγόντων, που έχουν συζητηθεί στη διεθνή βιβλιογραφία, αναφορικά με την πρόθεση των εργαζομένων να εργαστούν με τηλεργασία: α. πανδημία COVID-19, β. υποστηρικτικός προς την τηλεργασία προϊστάμενος/η, γ. υποστηρικτικός προς την τηλεργασία οργανισμός, δ. οικογενειακές υποχρεώσεις και ε. αλληλεξάρτηση των εργασιακών καθηκόντων με άλλες εργασίες του οργανισμού. Στη έρευνα συμμετείχαν 83 εργαζόμενοι του ελληνικού δημοσίου και ιδιωτικού τομέα (μέση ηλικία 36,7 έτη; 54,2% οι γυναίκες συμμετέχουσες). H συλλογή των δεδομένων πραγματοποιήθηκε κατά την έναρξη του δεύτερου κύματος της πανδημίας (Οκτώβριος-Δεκέμβριος 2020). Για την ανάλυση των δεδομένων, χρησιμοποιήθηκαν μοντέλα πολυεπίπεδης γραμμικής παλινδρόμησης. Τα αποτελέσματα των αναλύσεων ανέδειξαν την ύπαρξη της πανδημίας COVID-19 ως το σημαντικότερο προβλεπτικό παράγοντα για την πρόθεση τηλεργασίας και μερικής και πλήρους απασχόλησης, ενώ ακολούθησαν με φθίνουσα σειρά αντιλαμβανόμενης σημασίας, ο υποστηρικτικός προς την τηλεργασία προϊστάμενος/η, ο υποστηρικτικός προς την τηλεργασία οργανισμός, οι οικογενειακές υποχρεώσεις και τέλος η αλληλεξάρτηση των εργασιακών καθηκόντων. Τα ευρύματα της έρευνας, συμβάλουν στη συζήτηση σχετικά με τη σημασία των ατομικών και οργανωσιακών παραγόντων που επιδρούν στην πρόθεση των εργαζομένων για τηλεργασία.
Factors associated with the use of rehabilitation services among people with disabilities in Chile: A population-based study
Authors: Paredes-Laguna Dania Silvia , Calderón-Curiñaupa William Romeo , Soto-Nuñez Sandra Liz , Espinoza-Hoempler Adriana Berenice , Alarco J. Jhonnel 
Published: January 2023

Background: Rehabilitation services are necessary for people with disabilities to improve their quality of life and be included in society. This study aimed to determine the factors associated with the use of rehabilitation services among people with disabilities in Chile in 2015. Methods: This cross-sectional analysis of secondary data from Chile’s 2015 Second National Disability Study (ENDISC II) included people with disabilities aged ≥18 years. The dependent variable was the use of rehabilitation services in the previous year, and the exposure variables were sociodemographic and confounders. Poisson regression was used to determine associated factors, and prevalence ratios (PR) with their 95% confidence intervals (95% CI) were estimated. All results were weighted according to the ENDISC II complex sampling. Results: A total of 2610 people with disabilities were included, and 19.1% used some rehabilitation services in the previous year. Educational level (PR 0.43; 95% CI 0.25–0.75), having a mental illness (PR 1.77; 95% CI 1.44–2.18), and caregiver assistance (PR 1.57; 95% CI 1.25–1.97) were factors associated with the use of rehabilitation services. Conclusions: In 2015, one-fifth of people with disabilities in Chile used some rehabilitation services in the previous year. People with disabilities with lower educational levels were less likely to access these services. By contrast, people with mental illness and caregiver assistance were more likely to use rehabilitation services.
Unraveling the secrets of plant roots: Simplified method for large scale root exudate sampling and analysis in Arabidopsis thaliana
Authors: Subrahmaniam Harihar Jaishree , Lind Salomonsen Camilla , Radutoiu Simona , Ehlers Bodil K. , Glasius Marianne 
Published: January 2023

Background: Plants exude a plethora of compounds to communicate with their environment. Although much is known about above-ground plant communication, we are only beginning to fathom the complexities of below ground chemical communication channels. Studying root-exuded compounds and their role in plant communication has been difficult due to a lack of standardized methodologies. Here, we develop an interdisciplinary workflow to explore the natural variation in root exudate chemical composition of the model plant Arabidopsis thaliana. We highlight key challenges associated with sampling strategies and develop a framework for analyzing both narrow and broad scale patterns of root exudate composition in a large set of natural A. thaliana accessions. Methods: Our method involves cultivating individual seedlings in vitro inside a plastic mesh, followed by a short hydroponic sampling period in small quantities of ultrapure water. The mesh makes it easy to handle plants of different sizes and allows for large-scale characterization of individual plant root exudates in axenic conditions. This setup can also be easily extended for prolonged temporal exudate collection experiments. Furthermore, the short sampling time minimizes the duration of the experiment while still providing sufficient signal even with a small volume of sampling solution. We used ultra-high performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UHPLC-QTOF-MS) for untargeted metabolic profiling, followed by tentative compound identification using MZMine3 and SIRIUS 5 software, to capture a broad overview of root exudate composition in A. thaliana accessions. Results: Based on 28 replicates of Columbia genotype (Col-0) compared with 10 random biological controls, MZMine3 identified 354 metabolites to be present only in Col-0 by negative ionization. Of these, 313 compounds could be annotated by SIRIUS 5 software. Conclusions: The methodology developed in this study can be used to broadly investigate the role of root exudates as chemical signals in plant belowground interactions.