bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation and Follow-up of Myopia Prevalence Among School-Aged Children Subsequent to the COVID-19 Home Confinement in Feicheng, China
Authors: Wang Jiaxing , Han Yujie , Musch David C. , Li Ying , Wei Nan , Qi Xiaoli , Ding Gang , Li Xue , Li Jing , Song Linlin , Zhang Ying , Ning Yuxian , Zeng Xiaoyu , Li Yaoling , Sun Ling , Hua Ning , Li Shuo , Jardines Sandra , Qian Xuehan 
Published: February 2023

ImportanceProgression of myopia in a school-aged population due to home confinement (January to May 2021) during the COVID-19 pandemic has been previously reported. A key remaining question was whether the myopia spike in children aged 6 to 8 years persisted.ObjectiveTo investigate the changes in refractive status and prevalence of myopia in school-aged children 1 year after home confinement ended in China.Design, Setting, and ParticipantsThis cross-sectional study with a cohort substudy prospectively evaluated data from school-based photoscreening in Feicheng, China. Children aged 6 to 13 years participated in 8 screenings from 2015 to 2021.ExposuresNoncycloplegic photorefraction was conducted using the Spot Vision photoscreener.Main Outcomes and MeasuresThe main outcomes were the differences in spherical equivalent refraction (SER) and prevalence of myopia between 2020 (during home confinement) and 2021 (after home confinement). The SER was recorded for each child, and the prevalence of myopia was calculated annually for each age group.ResultsA total of 325 443 children participated in the study (51.4% boys, 48.6% girls; age range, 6 to 13 years). Compared with 2020, the mean SER of children in 2021 increased significantly for those aged 6 (0.42 diopters [D]), 7 (0.41 D), and 8 (0.33 D) years. The prevalence of myopia in 2021 was similar to in 2019 for each age group (aged 6 years: 7.9% vs 5.7%; aged 7 years: 13.9% vs 13.6%; aged 8 years: 29.5% vs 26.2%). Both the prevalence of myopia and mean SER for these children returned to their prepandemic levels.Conclusions and RelevanceCompared with 2020, the prevalence of myopia among children aged 6 to 8 years in the 2021 screenings decreased, and the mean SER returned to prepandemic level. The refractive development in children aged 6 to 8 years may be most susceptible to environmental changes. These findings support the premise that age 6 to 8 years is a critical period for myopia development and suggest a need to focus preventive interventions for myopia control on children in this age range.
Drug-Induced Sleep Endoscopy Differences by Age in Surgically Naive Children With Sleep-Disordered Breathing
Authors: Herzig Maya X. , Hildebrand Andrea D. , Nguyen Thuan , Lam Derek J. 
Published: February 2023

ImportanceDrug-induced sleep endoscopy (DISE) is increasingly used to guide treatment decisions in children with sleep-disordered breathing (SDB). Previous reports of DISE findings in children have typically included a broad age range, but it is unclear how these patterns of obstruction vary with age.ObjectiveTo compare patterns of airway obstruction observed during DISE in 3 age groups of surgically naive children with SDB.Design, Setting, and ParticipantsThis cross-sectional analysis of a prospective cohort of surgically naive nonsyndromic children with SDB or obstructive sleep apnea [OSA] at risk for residual disease after adenotonsillectomy (defined as having at least 1 of these criteria: severe OSA, older than 7 years, obesity, or Black race) who were recruited between May 1, 2015, and February 28, 2020, was conducted at a tertiary children’s hospital. Data analysis was conducted from September 2021 to February 2022.ExposuresDISE.Main Outcomes and MeasuresDISE findings were rated at 6 anatomic sites using the Sleep Endoscopy Rating Scale (SERS). The association between age and severity of obstruction at each anatomic site and overall were compared using correlation (Kendall τ) and ordinal logistic regression analysis.ResultsData from 288 children (144 girls [50%]; 20 American Indian/Alaska Native [7%], 4 Asian [1%], 19 Black [7%], 93 Hispanic [33%], 2 Middle Eastern [1%], 6 Native Hawaiian/Pacific Islander [2%], and 203 White [70%] individuals; median [IQR] age, 9.2 [7.0-11.7] years) were stratified by participant age into preschool (age 2-5 years; 27 [9%]), younger school-aged (age 5-10 years; 146 [51%]), and older school-aged (age 10-18 years; 115 [40%]). Among these subgroups, the prevalence of multilevel obstruction was 59%, 51%, and 30%, respectively. Increasing age was inversely correlated with obstruction of the nasal airway (τb, −0.19; 95% CI, −0.29 to −0.09), nasopharynx (τb, −0.20; 95% CI, −0.31 to −0.10), velopharynx (τb, −0.16; 95% CI, −0.26 to −0.06), and overall obstruction (SERS total score: τb, −0.24; 95% CI, −0.33 to −0.14). An adjusted analysis demonstrated an inverse association between age and nasopharyngeal obstruction (odds ratio [OR], 0.84; 95% CI, 0.76 to 0.92), SERS total score (OR, 0.83; 95% CI, 0.76 to 0.90), and the number of sites of complete obstruction (OR, 0.87; 95% CI, 0.87 to 0.95).Conclusions and RelevanceThis cross-sectional analysis of data from a prospective cohort study of surgically naive children with SDB found that preschool-aged children had more frequent multilevel obstruction, more severe overall obstruction, and nasopharyngeal obstruction compared with older children. Understanding the most common sites of obstruction and expected changes with age could inform personalized treatment for children with SDB.
Targeted therapy of advanced parathyroid carcinoma guided by genomic and transcriptomic profiling
Authors: Teleanu Maria‐Veronica , Fuss Carmina T. , Paramasivam Nagarajan , Pirmann Sebastian , Mock Andreas , Terkamp Christoph , Kircher Stefan , Landwehr Laura‐Sophie , Lenschow Christina , Schlegel Nicolas , Stenzinger Albrecht , Jahn Arne , Fassnacht Martin , Glimm Hanno , Hübschmann Daniel , Fröhling Stefan , Kroiss Matthias 
Published: February 2023

Parathyroid carcinoma (PC) is an ultra‐rare malignancy with a high risk of recurrence after surgery. Tumour‐directed systemic treatments for PC are not established. We used whole‐genome and RNA sequencing in four patients with advanced PC to identify molecular alterations that could guide clinical management. In two cases, the genomic and transcriptomic profiles provided targets for experimental therapies that resulted in biochemical response and prolonged disease stabilization: (a) immune checkpoint inhibition with pembrolizumab based on high tumour mutational burden and a single‐base substitution signature associated with APOBEC (apolipoprotein B mRNA editing enzyme, catalytic polypeptide‐like) overactivation; (b) multi‐receptor tyrosine kinase inhibition with lenvatinib due to overexpression of FGFR1 (Fibroblast Growth Factor Receptor 1) and RET (Ret Proto‐Oncogene) and, (c) later in the course of the disease, PARP (Poly(ADP‐Ribose) Polymerase) inhibition with olaparib prompted by signs of defective homologous recombination DNA repair. In addition, our data provided new insights into the molecular landscape of PC with respect to the genome‐wide footprints of specific mutational processes and pathogenic germline alterations. These data underscore the potential of comprehensive molecular analyses to improve care for patients with ultra‐rare cancers based on insight into disease biology.
Pressure Engineering Toward Harvesting the Bright Deep‐Blue‐Light Emission in Y‐based Metal‐Organic Frameworks
Authors: Wang Yixuan , Liu Chuang , Yong Xue , Yang Xinyi , Yu Jingkun , Lu Siyu , Bai Fuquan , Wang Shiping , Wang Kai , Liu Zhaodong , Feng Bingtao , Hou Xuyuan , Liu Hao , Chen Banglin , Fang Qianrong , Zou Bo 
Published: February 2023

AbstractThe emergence of metal‐organic frameworks (MOFs) provides a new platform of low‐cost and color‐saturated blue light‐emitting diodes ideal for display and solid‐state lighting applications. However, numerous established MOFs still exhibit weak deep‐blue‐light emission (<450 nm) owing to low energy/charge transfer efficiency. Here a pressure‐treated strategy to greatly enhance photoluminescence performance of deep‐blue light‐emitting Y(BTC)(H2O)6 (H3BTC: benzene‐1,3,5‐tricarboxylic acid) is reported. Pressure‐treated Y(BTC)(H2O)6 exhibits a bright emission at 409 nm with a photoluminescence quantum yield from the initial 2.8% increasing to 75.0%. The hydrogen bonding cooperativity effect increases hydrogen bond binding energy after pressure treatment and thus the planarization structure is locked. The increased electronic transition diversity and oscillator strength originating from the planarization structure are highly responsible for boosting metal‐to‐ligand charge transfer. The findings in this study provide significant insights into the underlying mechanism of the structure‐property relationship in Y(BTC)(H2O)6 and offer a promising strategy to harvest deep‐blue‐emitting MOFs materials.
Controlled Interfacial Polymer Self‐Assembly Coordinates Ultrahigh Drug Loading and Zero‐Order Release in Particles Prepared under Continuous Flow
Authors: Zhang Pei , Liu Yingxin , Feng Guobing , Li Cong , Zhou Jun , Du Chunyang , Bai Yuancheng , Hu Shuai , Huang Tianhe , Wang Guan , Quan Peng , Hirvonen Jouni , Fan Jin , Santos Hélder A. , Liu Dongfei 
Published: February 2023

AbstractMicroparticles are successfully engineered through controlled interfacial self‐assembly of polymers to harmonize ultrahigh drug loading with zero‐order release of protein payloads. To address their poor miscibility with carrier materials, protein molecules are transformed into nanoparticles, whose surfaces are covered with polymer molecules. This polymer layer hinders the transfer of cargo nanoparticles from oil to water, achieving superior encapsulation efficiency (up to 99.9%). To control payload release, the polymer density at the oil–water interface is enhanced, forming a compact shell for microparticles. The resultant microparticles can harvest up to 49.9% mass fraction of proteins with zero‐order release kinetics in vivo, enabling an efficient glycemic control in type 1 diabetes. Moreover, the precise control of engineering process offered through continuous flow results in high batch‐to‐batch reproducibility and, ultimately, excellent scale‐up feasibility.
Analytical Physical Model for Electrolyte Gated Organic Field Effect Transistors in the Helmholtz Approximation
Authors: Huetter Larissa , Kyndiah Adrica , Gomila Gabriel 
Published: February 2023

AbstractThe analytical physical modeling of undoped electrolyte gated organic field effect transistors (EGOFETs) in the Helmholtz approximation is presented. A compact analytical model for the current–voltage (I–V) characteristics, which includes the effects of the access series resistance, has been derived and validated by means of 2D finite element numerical calculations. The model describes all operating regimes continuously (subthreshold, linear, and saturation regimes), covers channel lengths down to a few micrometres and only includes physical device parameters. From the model, analytical expressions have been proposed for all the phenomenological parameters (e.g., capacitance, threshold voltage, sub‐threshold slope voltage, and sub‐threshold capacitance) appearing in the commonly used ideal FET model. The derived analytical physical model provides a simple and quantitative way to analyze the electrical characteristics of EGOFETs and EGOFET biosensors beyond the use of the oversimplified and phenomenological ideal FET model.
H3K4 Methylation Promotes Expression of Mitochondrial Dynamics Regulators to Ensure Oocyte Quality in Mice
Authors: Mei Ning‐hua , Guo Shi‐meng , Zhou Qi , Zhang Yi‐ran , Liu Xiao‐zhao , Yin Ying , He Ximiao , Yang Jing , Yin Tai‐lang , Zhou Li‐quan 
Published: February 2023

AbstractSignificantly decreased H3K4 methylation in oocytes from aged mice indicates the important roles of H3K4 methylation in female reproduction. However, how H3K4 methylation regulates oocyte development remains largely unexplored. In this study, it is demonstrated that oocyte‐specific expression of dominant negative mutant H3.3‐K4M led to a decrease of the level of H3K4 methylation in mouse oocytes, resulting in reduced transcriptional activity and increased DNA methylation in oocytes, disturbed oocyte developmental potency, and fertility of female mice. The impaired expression of genes regulating mitochondrial functions in H3.3‐K4M oocytes, accompanied by mitochondrial abnormalities, is further noticed. Moreover, early embryos from H3.3‐K4M oocytes show developmental arrest and reduced zygotic genome activation. Collectively, these results show that H3K4 methylation in oocytes is critical to orchestrating gene expression profile, driving the oocyte developmental program, and ensuring oocyte quality. This study also improves understanding of how histone modifications regulate organelle dynamics in oocytes.
MIR497HG‐Derived miR‐195 and miR‐497 Mediate Tamoxifen Resistance via PI3K/AKT Signaling in Breast Cancer
Authors: Tian Yao , Chen Zhao‐Hui , Wu Peng , Zhang Di , Ma Yue , Liu Xiao‐Feng , Wang Xin , Ding Dan , Cao Xu‐Chen , Yu Yue 
Published: February 2023

AbstractTamoxifen is commonly used for the treatment of patients with estrogen receptor‐positive (ER+) breast cancer, but the acquired resistance to tamoxifen presents a critical challenge of breast cancer therapeutics. Recently, long noncoding RNA MIR497HG and its embedded miR‐497 and miR‐195 are proved to play significant roles in many types of human cancers, but their roles in tamoxifen‐resistant breast cancer remain unknown. The results indicate that MIR497HG deficiency induces breast cancer progression and tamoxifen resistance by inducing downregulation of miR‐497/195. miR‐497/195 coordinately represses five positive PI3K‐AKT regulators (MAP2K1, AKT3, BCL2, RAF1, and CCND1), resulting in inhibition of PI3K‐AKT signaling, and PI3K‐AKT inhibition in tamoxifen‐resistant cells restored tamoxifen responsiveness. Furthermore, ER α binds the MIR497HG promoter to activate its transcription in an estrogen‐dependent manner. ZEB1 interacts with HDAC1/2 and DNMT3B at the MIR497HG promoter, resulting in promoter hypermethylation and histone deacetylation. The findings reveal that ZEB1‐induced MIR497HG depletion contributes to breast cancer progression and tamoxifen resistance through PI3K‐AKT signaling. MIR497HG can be used as a biomarker for predicting tamoxifen sensitivity in patients with ER+ breast cancer.
Immunogenic Cell Death in Hematological Malignancy Therapy
Authors: Liu Zhaoyun , Xu Xintong , Liu Kaining , Zhang Jingtian , Ding Dan , Fu Rong 
Published: February 2023

AbstractAlthough the curative effect of hematological malignancies has been improved in recent years, relapse or drug resistance of hematological malignancies will eventually recur. Furthermore, the microenvironment disorder is an important mechanism in the pathogenesis of hematological malignancies. Immunogenic cell death (ICD) is a unique mechanism of regulated cell death (RCD) that triggers an intact antigen‐specific adaptive immune response by firing a set of danger signals or damage‐associated molecular patterns (DAMPs), which is an immunotherapeutic modality with the potential for the treatment of hematological malignancies. This review summarizes the existing knowledge about the induction of ICD in hematological malignancies and the current research on combining ICD inducers with other treatment strategies for hematological malignancies.
Is paid sick leave bad for business? A systematic review
Authors: Vander Weerdt Candice , Stoddard‐Dare Patricia , DeRigne LeaAnne 
Published: February 2023

AbstractVigorous legislative activity both for and against paid sick leave has occurred over the last decade. Although a compelling body of evidence suggests that paid sick leave supports personal and public health goals, a notable barrier in opposition to paid sick leave is apprehension about the potential short‐term and long‐term harms to business. This review critically assesses the relationship between paid sick leave and favorable or unfavorable business conditions. Utilizing the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) guidelines, we systematically review six research databases between 2000 and November 2022. Of 2664 studies identified, 123 were considered potentially relevant and 43 were included in the review. In addition to absence from work, paid sick leave was associated with favorable business conditions such as increased job satisfaction; improved retention; and reductions in occupational injury, contagion, presenteeism, and death; as well as some measures of firm performance and labor market conditions. Overall, our review discovered more evidence supporting the relationship between paid sick leave and favorable business conditions as compared with evidence that supported unfavorable business conditions. Although more research is needed, these findings can be used to inform firm‐level and public policy decisions about paid sick leave.
Key achievements of New South Wales local government Disability Inclusion Action Plans in the era of inclusion policy and planning: A policy content analysis
Authors: Butler Katie 
Published: February 2023

AbstractContributing to a national policy reform intended to make meaningful advancements to the social and economic inclusion of disabled people, local government councils in NSW, Australia, have been required to have in place a Disability Inclusion Action Plan since 2017 under the Disability Inclusion Act of 2014. Five years on, this qualitative policy content analysis examined the key achievements promoted by 32 councils under the first generation of plans, and also identified where action has been limited. Councils were found to have invested significantly in making improvements to the built environment. Hosting accessible events and programs was also a commonly reported achievement, as was facilitating access to accessible information and technology. Councils took proactive roles in supporting and educating communities, business and their employees in inclusive practice. There were many achievements related to employment opportunities; however, these were generally narrow in expectation and impact, suggesting this was the area councils struggled with most. Councils also showed they were forecasting ahead, outlining consultative processes and policy changes, which would influence systemic improvements in accessibility and inclusion into the future. Councils have taken significant steps to advance the inclusion agenda; however, there remain areas where greater attention and support are required.
The preoperative SOFA score and remnant small intestine length are postoperative risk factors for mortality in patients with non‐occlusive mesenteric ischemia: a case–control study
Authors: Umemoto Kazufumi , Kato Kentaro , Yamabuki Takumi , Takada Minoru , Ambo Yoshiyasu , Nakamura Fumitaka , Hirano Satoshi 
Published: February 2023

AimNon‐occlusive mesenteric ischemia (NOMI) is a fatal condition with a low survival rate in most cases. The risk factors for perioperative mortality in NOMI cases are unclear. The purpose of this study was to define the risk factors for mortality in patients with NOMI undergoing surgery.MethodsThirty‐eight consecutive patients who underwent surgery for NOMI at Teine Keijinkai Hospital between 2012 and 2020 were included in the study. Patient information, including age, sex, physical findings, comorbidities, laboratory data, and computed tomography and surgical findings were retrospectively analyzed.ResultsOf the 38 patients, 18 (47%) died before discharge. Significant univariate predictors of mortality were a high Sequential Organ Failure Assessment (SOFA) score, high lactate level, low blood pH, and short intestinal length after surgery. In the multivariate analysis, a high SOFA score (odds ratio 1.33, P = 0.036) and short intestine length after surgery (odds ratio 34.7, P = 0.003) were identified as independent risk factors for perioperative mortality.ConclusionThe preoperative SOFA score and postoperative residual intestinal length may be predictors of death in NOMI surgical patients, not age and the content of comorbidities.
Development and validation of an HPLC coupled with tandem mass spectrometry method for the determination of HSK7653, a novel super long‐acting dipeptidyl peptidase‐4 inhibitor, in human plasma and urine and its application to a pharmacokinetic study
Authors: Liu Yang , Yan Shuai , Liu Jie , Liu Hongzhong , Song Ling , Yao Xueting , Jiang Ji , Li Fangqiong , Du Ke , Liu Dongyang , Hu Pei 
Published: February 2023

AbstractHSK7653 is a novel super long‐acting dipeptidyl peptidase‐4 inhibitor, which is promising for the treatment of type 2 diabetes mellitus with the twice‐monthly dosing regimen. In this article, a robust and sensitive HPLC coupled with tandem mass spectrometry method for determining the concentration of HSK7653 in human plasma and urine was developed and validated for the first time. Plasma and urine samples were prepared by protein precipitation. After that, the extracts were analyzed using an LC‐20A HPLC system coupled with API 4000 tandem MS equipped with an electrospray ionization source in positive mode. Separation was obtained using an XBridge Phenyl column (2.1 × 50 mm, 3.5 μm) with a gradient elution of acetonitrile and water containing 0.1% formic acid and 5% acetonitrile at room temperature. This bioanalysis method has been fully validated and the results showed good sensitivity and specificity. In brief, the standard curves were linear over the concentration range of 2.00–2000 ng/ml for plasma and 20.0–20,000 ng/ml for urine, respectively. In addition, the precisions of inter‐ and intra‐run of HSK7653 were less than 12.7% and the accuracies were −3.3% to 6.3% for both plasma and urine. Finally, this method was successfully applied to explore the pharmacokinetic characteristics of HSK7653 in Chinese healthy volunteers in a first‐in‐human study.
Advancing students' trouble shooting skills with open‐ended questions and computer‐aided learning using Aspen Plus® in a multistage lab experiment
Authors: Elkhatat Ahmed M. , Al‐Muhtaseb Shaheen A. 
Published: February 2023

AbstractOpen‐ended questions and a computer‐aided learning approach using the Aspen Plus® Sensitivity Analysis Tool (OEQ‐CAL/APSAT) was used to simulate a multistage lab experiment of a piping system (consisting of pumps, pipes, and valves) as part of the Fluid Dynamics and Heat Transfer Laboratory course delivered within the Qatar University's curriculum for the Bachelor of Science degree in Chemical Engineering. To evaluate the learning goals of this approach, three‐stage experiments were used. Results indicated that students gained a deep understanding of the material and showed a strong interest, demonstrated by the student's participation in the OEQ‐CAL/APSAT activity. As the complexity and realistic nature of cases being studied can be increased using this approach, laboratory courses can be taught more effectively, and the corresponding investigations can be expanded with virtual experiments. In addition, it is a practical choice to maximize the use of resources and an effective replacement for laboratory experiments in case of pandemics, confinement, or interest in testing the effects of hazardous conditions to ensure sustained learning outcomes.