bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of a legume-enriched feed for treatment of severe acute malnutrition
Authors: Walsh Kevin , Delamare de la Villenaise de Chenevarin Gael , McGurk Joe , Maitland Kathryn , Frost Gary 
Published: January 2023

Background: Outcomes in children hospitalised with severe acute malnutrition (SAM) remain poor. The current milk-based formulations focus on restoring weight-gain but fail to address modification of the integrity of the gut barrier and may exacerbate malabsorption owing to functional lactase, maltase and sucrase deficiency. We hypothesise that nutritional feeds should be designed to promote bacterial diversity and restore gastrointestinal (GI) barrier function. Methods: Our major objective was to develop a lactose-free, fermentable carbohydrate-containing alternative to traditional F75 and F100 formulae for the inpatient treatment of SAM. New target nutritional characteristics were developed and relevant food and infant food specific legislation were reviewed. Suitable certified suppliers of ingredients were identified. Processing and manufacture steps were evaluated and optimised for safety (nutritional, chemical and microbiological), and efficacy at meeting target characteristics (lactose-free, containing resistant starch 0.4-0.5% final product weight). Results: A final validated production process was developed and implemented to produce a novel food product for the inpatient treatment of SAM in children in Africa designed to reduce risk of osmotic diarrhoea and support symbiotic gut microbial populations. The final product matched the macronutrient profile of double-concentrated F100, adhered to all relevant legislation regulating infant foods, was lactose free, and contained 0.6% resistant starch. Chickpeas were selected as the source of resistant starch, since they are widely grown and eaten throughout Africa. Micronutrient content could not be matched in this ready-to-use product, so this was replaced at the point of feeding, as was fluid lost through concentration. Conclusions: The processes and product described illustrate the development steps for a novel nutritional product. The new feed product was ready for evaluation for safety and efficacy in a phase II clinical trial in Ugandan children admitted to hospital with SAM (Modifying Intestinal MicroBiome with Legume-Based feed 2: MIMBLE feed 2 (ISRCTN10309022)).
Asymmetric Information of Product Authenticity on C2C E-Commerce Platforms: How Can Inspection Services Help?
Authors: Li Linqiu , Fang Xin , Lim Yun Fong 
Published: January 2023

Problem definition: We consider a customer-to-customer (C2C) platform that provides an inspection service. Uncertain about product authenticity, a seller sells a product through the platform. Before purchasing, a buyer obtains a signal of the product authenticity from the product’s price set by the seller. The platform’s inspection service can detect a counterfeit with a probability. If the product passes the inspection, the platform sends it to the buyer and charges the seller a commission fee. Otherwise, the platform returns it to the seller and charges the seller a penalty fee. Methodology/results: We develop a two-stage game-theoretical model. In the first stage, the platform designs a contract specifying the commission and penalty fees. In the second stage, the seller signals the product authenticity by setting a price and the buyer decides whether to purchase it. This results in a contract design problem that governs a signaling game. We find that the effect of inspection is beyond merely detecting counterfeits. The inspection, even an imperfect one, changes the signaling game’s structure and incentivizes the seller whose product is likely authentic to sell through the platform. This can only be achieved by carefully choosing the commission and penalty fees. Moreover, a larger platform’s expected profit does not imply a larger commission fee or price in equilibrium. Under some mild conditions, the optimal commission increases but the optimal penalty decreases as the platform’s inspection capability improves. Managerial implications: The inspection service is not widely available among leading C2C platforms as it is considered imperfect and costly. Our study suggests that its benefit may be underestimated in practice. Moreover, the inspection can eliminate the seller’s information rent and generate more revenue for the platform. This paper provides guidance on how to set commission and penalty fees when the inspection service is provided. Funding: L. Li is supported by the National Natural Science Foundation of China [Grant 72071198] and the Hong Kong Polytechnic University Distinguished Postdoctoral Fellowship Scheme [Grant 1-YWC7]. X. Fang and Y. F. Lim are grateful for the support from the Lee Kong Chian School of Business, Singapore Management University [Maritime and Port Authority Research Fellowship and Retail Centre of Excellence Research Grant]. Y. F. Lim is supported by the Association of South-East Asian Nations Business Research Initiative Grant [Grant G17C20421], the Research Grants Council of Hong Kong [Grants 15501920 and 15501221], and the Key Program of National Natural Science Foundation of China [Grant 71931009]. Supplemental Material: The online appendices are available at https://doi.org/10.1287/msom.2023.1186 .
Incidence and risk factors of cardiovascular mortality in patients with gastrointestinal adenocarcinoma
Authors: Nso Nso , Nyabera Akwe , Nassar Mahmoud , Mbome Yolanda , Emmanuel Kelechi , Alshamam Mohsen , Sumbly Vickram , Guzman Laura , Shaukat Tanveer , Bhangal Rubal , Ojong Gilbert Ako , Radparvar Farshid , Rizzo Vincent , Munira Most Sirajum 
Published: January 2023

Background
Gastrointestinal (GI) cancers are common and fatal. Improved cancer-directed therapies, with thier substantial role in improving cancer-specific survival, may increase non-cancer mortality−including cardiovascular mortality−in these patients.

Aim
To identify the risk factors of cardiovascular mortality in GI adenocarcinoma patients.

Methods
Data of GI adenocarcinoma patients were gathered from the Surveillance, Epidemiology, and End Results database. We used Pearson’s chi-square test to assess the relationships between categorical variables. We used the Kaplan-Meyer test in the univariate analysis and Cox regression test for the multivariate analysis.

Results
Among 556,350 included patients, 275,118 (49.6%) died due to adenocarcinoma, 64,079 (11.5%) died due to cardiovascular causes, and 83,161 (14.9%) died due to other causes. Higher rates of cardiovascular mortality were found in patients ≥ 50 years (HR, 8.476; 95% CI, 7.91–9.083), separated (HR, 1.27; 95% CI, 1.184–1.361) and widowed (HR, 1.867; 95% CI, 1.812–1.924), patients with gastric (HR, 1.18; 95% CI, 1.1–1.265) or colorectal AC (HR, 1.123; 95% CI, 1.053–1.198), and patients not undergone surgery (HR, 2.04; 95% CI, 1.958–2.126). Lower risk patients include females (HR, 0.729; 95% CI, 0.717–0.742), blacks (HR, 0.95; 95% CI, 0.924–0.978), married (HR, 0.77; 95% CI, 0.749–0.792), divorced (HR, 0.841; 95% CI, 0.807–0.877), patients with pancreatic AC (HR, 0.83; 95% CI, 0.757–0.91), and patients treated with chemotherapy (HR, 0.416; 95% CI, 0.406–0.427).

Conclusions
Risk factors for cardiovascular mortality in GI adenocarcinoma include advanced age, males, whites, separated and widowed, gastric or colorectal adenocarcinoma, advanced grade or advanced stage of the disease, no chemotherapy, and no surgery. Married and divorced, and patients with pancreatic adenocarcinoma have a lower risk.
Correlation between metastatic patterns and age in patients with metastatic primary liver cancer: A population-based study
Authors: Zheng Zhaoting , Hu Yue , Ren Yutong , Mo Guoheng , Wan Hao 
Published: January 2023

Aim
Primary liver cancer is usually diagnosed at advanced stages with distant metastasis, underlying the high metastatic rate and mortality in patients. This study aimed to analyse the metastatic patterns and prognosis of primary liver cancer, and its relationship with age and several other factors, such as histological variants, TNM stage, and grade.

Methods
We included data from 5274 patients from the Surveillance, Epidemiology, and End Results (SEER) database of the American National Cancer Institute diagnosed with primary liver cancer with metastatic disease between 2010 and 2015. The correlation between the metastatic patterns of primary liver cancer and age was evaluated. The hazard ratio (HR) and 95% confidence intervals (CI) for overall survival were calculated by applying univariate Cox analysis, while the correlation between the metastatic patterns and age was analysed by applying multivariate Cox analysis. We also plotted Kaplan-Meier curves to illustrate the correlation between overall survival (OS) and various factors.

Results
Several factors were associated with poorer prognosis, including age>60 years, histologic type of spindle cell variant, higher grade, no surgery, tumour size ≥ 1 cm, and lung metastasis. The rate of metastasis increased with age. Older patients (> 50 years) were prone to bone metastasis, while less likely to have lung metastasis compared with younger patients (< 50 years). Patients with lung metastasis had a higher risk of being diagnosed with metastasis in other locations. Furthermore, surgery significantly reduced mortality and primary site surgery in particular, mitigated the risk of bone and lung metastases.

Conclusions
Our study shows the correlation of prognosis and metastatic patterns with age and several other factors. The findings can hopefully provide knowledge that will allow a better diagnosis and management of elderly patients with primary liver cancer.
Global prevalence of nosocomial infection: A systematic review and meta-analysis
Authors: Raoofi Samira , Pashazadeh Kan Fatemeh , Rafiei Sima , Hosseinipalangi Zahra , Noorani Mejareh Zahra , Khani Saghar , Abdollahi Bahare , Seyghalani Talab Fatemeh , Sanaei Mohaddeseh , Zarabi Farnaz , Dolati Yasamin , Ahmadi Niloofar , Raoofi Neda , Sarhadi Yasamin , Masoumi Maryam , sadat Hosseini Batool , Vali Negin , Gholamali Negin , Asadi Saba , Ahmadi Saba , Ahmadi Behrooz , Beiramy Chomalu Zahra , Asadollahi Elnaz , Rajabi Mona , Gharagozloo Dorsa , Nejatifar Zahra , Soheylirad Rana , Jalali Shabnam , Aghajani Farnaz , Navidriahy Mobina , Deylami Sama , Nasiri Mahmoud , Zareei Mahsa , Golmohammadi Zahra , Shabani Hamideh , Torabi Fatemeh , Shabaninejad Hosein , Nemati Ali , Amerzadeh Mohammad , Aryankhesal Aidin , Ghashghaee Ahmad 
Published: January 2023

Objectives
Hospital-acquired infections (HAIs) are significant problems as public health issues which need attention. Such infections are significant problems for society and healthcare organizations. This study aimed to carry out a systematic review and a meta-analysis to analyze the prevalence of HAIs globally.

Methods
We conducted a comprehensive search of electronic databases including EMBASE, Scopus, PubMed and Web of Science between 2000 and June 2021. We found 7031 articles. After removing the duplicates, 5430 studies were screened based on the titles/ abstracts. Then, we systematically evaluated the full texts of the 1909 remaining studies and selected 400 records with 29,159,630 participants for meta-analysis. Random-effects model was used for the analysis, and heterogeneity analysis and publication bias test were conducted.

Results
The rate of universal HAIs was 0.14 percent. The rate of HAIs is increasing by 0.06 percent annually. The highest rate of HAIs was in the AFR, while the lowest prevalence were in AMR and WPR. Besides, AFR prevalence in central Africa is higher than in other parts of the world by 0.27 (95% CI, 0.22–0.34). Besides, E. coli infected patients more than other micro-organisms such as Coagulase-negative staphylococci, Staphylococcus spp. and Pseudomonas aeruginosa. In hospital wards, Transplant, and Neonatal wards and ICU had the highest rates. The prevalence of HAIs was higher in men than in women.

Conclusion
We identified several essential details about the rate of HAIs in various parts of the world. The HAIs rate and the most common micro-organism were different in various contexts. However, several essential gaps were also identified. The study findings can help hospital managers and health policy makers identify the reason for HAIs and apply effective control programs to implement different plans to reduce the HAIs rate and the financial costs of such infections and save resources.
Contribution of remote M.tuberculosis infection to tuberculosis disease: A 30-year population study
Authors: Glynn Judith R. , Khan Palwasha , Mzembe Themba , Sichali Lifted , Fine Paul E. M. , Crampin Amelia C. , Houben Rein M. G. J. 
Published: January 2023

Background
The importance of remote infection with M.tuberculosis as a cause of tuberculosis disease (TB) is unclear, with limited evidence of impact on TB rates beyond 10 years. Our objective was to assess rates of tuberculosis over 30 years by M.tuberculosis infection status at baseline in Karonga District, Northern Malawi.

Materials and methods
Population-based surveys of tuberculin skin testing (TST) from the 1980s were linked with follow-up and TB surveillance in Karonga district. We compared rates of microbiologically-confirmed TB by baseline TST induration <5mm (no evidence of M.tuberculosis infection) and those with baseline TST >17mm (evidence of M.tuberculosis infection), using hazard ratios by time since baseline and attributable risk percent. The attributable risk percent was calculated to estimate the proportion of TB in those infected that can be attributed to that prior infection. We analysed whole genome sequences of M.tuberculosis strains to identify recent transmission.

Results
Over 412,959 person-years, 208 incident TB episodes were recorded. Compared to the small induration group, rates of TB were much higher in the first two years in the large induration group, and remained higher to 20 years: age, sex and area-adjusted hazard ratios (HR) 2–9 years post-TST 4.27 (95%CI 2.56–7.11); 10–19 years after TST 2.15 (1.10–4.21); ≥20 years post-TST 1.88 (0.76–4.65). The attributable risk percent of remote infection was 76.6% (60.9–85.9) 2–9 years post-TST, and 53.5% (9.1–76.2) 10–19 years post-TST. Individuals with large TST indurations had higher rates of unique-strain TB (HR adjusted for age, sex and area = HR 6.56 (95% CI 1.96–22.99)), suggesting disease following remote infection, but not of linked-strain TB (recent transmission).

Conclusions
M.tuberculosis infection can increase the risk of TB far beyond 10 years, accounting for a substantial proportion of TB occurring among those remotely infected.
Developing a fall prevention intervention economic model
Authors: Saunders Hailey , Anderson Carol , Feldman Fabio , Holroyd-Leduc Jayna , Jain Ravi , Liu Barbara , Macaulay Susan , Marr Sharon , Silvius James , Weldon Jennifer , Bayoumi Ahmed M. , Straus Sharon E. , Tricco Andrea C. , Isaranuwatchai Wanrudee 
Published: January 2023

Purpose
Model-based economic evaluations require conceptualization of the model structure. Our objectives were to identify important health states, events, and patient attributes to be included in a model-based cost-effectiveness analysis of fall prevention interventions, to develop a model structure to examine cost-effectiveness of fall prevention interventions, and to assess the face validity of the model structure.

Methods
An expert panel comprising clinicians, health service researchers, health economists, a patient partner, and policy makers completed two rounds of online surveys to gain consensus on health states, events, and patient attributes important for fall prevention interventions. The surveys were informed by a literature search on fall prevention interventions for older adults (≥65 years) including economic evaluations and clinical practice guidelines. The results of the Delphi surveys and subsequent discussions can support the face validity of a state-transition model for an economic evaluation of fall prevention interventions.

Results
In total, 11 experts rated 24 health states/events and 41 patient attributes. Consensus was achieved on 14 health states/events and 26 patient characteristics. The proposed model structure incorporated 12 of the 14 selected health states/events. Panelists confirmed the face validity of the model structure during teleconferences.

Conclusions
There is a dearth of studies presenting the model conceptualization process; consequently, this study involving multiple end user partners with opportunities for input at several stages adds to the literature as another case study. This process is an example of how a fall prevention economic model was developed using a modified Delphi process and assessed for face validity.
Self-perception of physical appearance of adolescents and associated factors in Addis Ababa, Ethiopia
Authors: Abdo Ziyad Ahmed , Seid Semira Ahmed , Woldekiros Aynye Negesse 
Published: January 2023

Introduction
Establishing a positive body image is a critical factor for adolescents’ physical and mental health, as it determines self-confidence, and sustainable individual growth and development throughout their lives. This reality needs to be supported by evidences generated locally. However, there is a lack of information in this regard in the study setting. Thus, the aim of this study was to assess the self-perception of one’s physical appearance and its associated factors among adolescents in Addis Ababa, Ethiopia.

Methods and materials
A community-based, cross-sectional study design was used to conduct the study. At the end of the multistage sampling procedure, a systematic random sampling technique was employed to select 308 study participants from selected districts. The questionnaire was adapted from previous studies as it was appropriate for local context. The data collectors were trained before the data collection and supervised during the data collection period, and the questionnaire was pretested. Bivariate logistic regression was used to identify candidate variables, and then variables with p<0.2 were taken to multiple logistic regressions to identify independent associated factors. Statistical significance was considered at P <0.05 with adjusted odds ratios calculated at 95% CIs.

Result
A total of 283 adolescents were participated in the study, with a response rate of 91.9%. The overall good self-perception of one’s physical appearance was 48.4% [95% CI = 43.8, 54.1]. Having a BMI between 18.5 kg/m2-24.9 kg/m2 (AOR = 2.56; 95% CI: 1.45, 4.54), presence of enough sport fields in the school (AOR = 1.89; 95% CI: 1.09, 3.29), having daily access to internet services (AOR = 1.69; 95% CI: 1.07, 2.94), following Ethiopian movies/cinemas (AOR = 2.46; 95% CI: 1.46, 4.15), and regularly following western movies/cinemas (AOR = 2.0; 95% CI: 1.11, 3.59) were significantly associated with a good self-perception of one’s physical appearance.

Conclusion
According to this study, only 48.4% of respondents reported a good self-perception of their physical appearance. Adolescents and their family need to work to bring normal body mass index, which in turn will increase good self-perceptions of their physical appearance. Schools and the local administrations need to increase availability and access to enough sport fields for students to strengthen their physical fitness, which increases their good self-perception of their physical appearance.
Exercise Training Is Associated With Treatment Response in Liver Fat Content by Magnetic Resonance Imaging Independent of Clinically Significant Body Weight Loss in Patients With Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis
Authors: Stine Jonathan G. , DiJoseph Kara , Pattison Zach , Harrington Alex , Chinchilli Vernon M. , Schmitz Kathryn H. , Loomba Rohit 
Published: January 2023

INTRODUCTION:
Exercise training is crucial in the management of nonalcoholic fatty liver disease (NAFLD); however, whether it can achieve clinically meaningful improvement in liver fat is unclear. We investigated the association between exercise training and the achievement of validated thresholds of MRI-measured treatment response.

METHODS:
Randomized controlled trials in adults with NAFLD were identified through March 2022. Exercise training was compared with no exercise training. The primary outcome was ≥30% relative reduction in MRI-measured liver fat (threshold required for histologic improvement in nonalcoholic steatohepatitis activity, nonalcoholic steatohepatitis resolution, and liver fibrosis stage). Different exercise doses were compared.

RESULTS:
Fourteen studies (551 subjects) met inclusion criteria (mean age 53.3 yrs; body mass index 31.1 kg/m2). Exercise training subjects were more likely to achieve ≥30% relative reduction in MRI-measured liver fat (odds ratio 3.51, 95% confidence interval 1.49–8.23, P = 0.004) than those in the control condition. An exercise dose of ≥750 metabolic equivalents of task min/wk (e.g., 150 min/wk of brisk walking) resulted in significant treatment response (MRI response odds ratio 3.73, 95% confidence interval 1.34–10.41, P = 0.010), but lesser doses of exercise did not. Treatment response was independent of clinically significant body weight loss (>5%).

DISCUSSION:
Independent of weight loss, exercise training is 3 and a half times more likely to achieve clinically meaningful treatment response in MRI-measured liver fat compared with standard clinical care. An exercise dose of at least 750 metabolic equivalents of task-min/wk seems required to achieve treatment response. These results further support the weight-neutral benefit of exercise in all patients with NAFLD.
Temporal relationships among changes in the RR‐interval and the powers of the low‐ and high‐frequency components of heart rate variability in normal subjects
Authors: Yokobori Yuji , Nakane Hayato , Uehara Chirika , Nagasawa Toru , Mitsuyama Satoshi , Ohkawa Kiyomi , Kario Kazuomi , Ozawa Seiji 
Published: January 2023

AbstractSpectral analysis of heart rate variability (HRV) is widely used as a non‐invasive method to assess the cardiovascular autonomic function. Of the two main frequency components of HRV, namely low‐frequency (LF, 0.04–0.15 Hz) and high‐frequency (HF, 0.15–0.4 Hz) components, it is generally accepted that the HF power reflects modulation of heart rate which is mediated by cardiac parasympathetic (vagal) nerve activity. In contrast, the origin and functional correlates of the LF component are still controversial. Although several lines of evidence have indicated a close correlation between LF power and the baroreflex modulation of autonomic outflows, the detailed mechanisms underlying the genesis of the LF component remain unclarified. In this study, we conducted an ultra‐short‐term (UST) spectral analysis of R‐R interval (RRI) time series using Fast Fourier Transform (FFT) with 5‐ and 25‐s windows to clarify the temporal relationships among transient changes in the RRI and, LF and HF powers in healthy subjects. We found that during active standing, transient RRI increases occurred sporadically. The UST spectral analysis revealed that this RRI increase was associated with a simultaneous increase in HF power which was closely linked to the prominent LF power increase. These results indicate that during active standing, increases in LF and HF powers occur simultaneously, and they may reflect enhanced cardiac vagal activity which generates transient bradycardia.