bluuebunny/crossref_metadata_2025_split huggingface dataset:
Astragaloside IV alleviates neuronal ferroptosis in ischemic stroke by regulating fat mass and obesity‐associated—N6‐methyladenosine—acyl‐CoA synthetase long‐chain family member 4 axis
Authors: Jin Zhenglong , Gao Wenying , Guo Fu , Liao Shaojun , Hu Mingzhe , Yu Tao , Yu Shangzhen , Shi Qing 
Published: June 2023

AbstractIschemic stroke (IS) is a detrimental neurological disease with limited treatment options. Astragaloside IV (As‐IV) was a promising bioactive constituent in the treatment of IS. However, the functional mechanism remains unclear. Here, IS cell and mouse models were established by oxygen glucose deprivation/re‐oxygenation (OGD/R) and middle cerebral artery occlusion (MCAO). Quantitative reverse transcription PCR (RT–qPCR), Western blotting, or Immunofluorescence staining measured related gene and protein expression of cells or mice brain tissues, and the results revealed altered expression of acyl‐CoA synthetase long‐chain family member 4 (Acsl4), fat mass and obesity‐associated (Fto), and activation transcription factor 3 (Atf3) after treatment with As‐IV. Then, increased N6‐methyladenosine (m6A) levels caused OGD/R or MCAO were reduced by As‐IV according to the data from methylated RNA immunoprecipitation (MeRIP)‐qPCR and dot blot assays. Moreover, through a series of functional experiments such as observing mitochondrial changes under transmission electron microscopy (TEM), evaluating cell viability by cell counting kit‐8 (CCK‐8), analyzing infract area of brain tissues by 2,3,5‐triphenyltetrazolium chloride (TTC) staining, measuring levels of malondialdehyde (MDA), lactate dehydrogenase (LDH), Fe2+, solute carrier family 7 member 11 (Slc7a11) and glutathione peroxidase 4 (Gpx4) and concentration of glutathione (GSH), we found that Fto knockdown, Acsl4 overexpression or Atf3 knockdown promoted the viability of OGD/R cells, inhibited cell ferroptosis, reduced infract size, while As‐IV treatment or Fto overexpression reversed these changes. In mechanism, the interplays of YTH N6‐methyladenosine RNA‐binding protein 3 (Ythdf3)/Acsl4 and Atf3/Fto were analyzed by RNA‐pull down, RNA immunoprecipitation (RIP), chromatin immunoprecipitation (ChIP) and dual‐luciferase reporter assay. Fto regulated the m6A levels of Acsl4. Ythdf3 bound to Acsl4, and modulated its levels through m6A modification. Atf3 bound to Fto and positively regulated its levels. Overall, As‐IV promoted the transcription of Fto by upregulating Atf3, resulting in decreased m6A levels of Acsl4, thus, improving neuronal injury in IS by inhibiting ferroptosis.image
Vertebral artery foraminal segment doppler sonography to detect vertebral and basilar artery stenosis or occlusion
Authors: Lee Seung‐Jae , Lee Tae‐Kyeong , Moon Ji Eun 
Published: June 2023

AbstractBackground and PurposeThe diagnostic value of vertebral artery foraminal segment (V2) ultrasonography remains unclear. This study aimed to estimate the predictive value of V2 Doppler imaging for the detection of vertebrobasilar stenosis or occlusion.MethodsThree hundred sixty‐four vertebral arteries from 182 patients were investigated. Abnormal Doppler spectra were categorized as high‐resistance flow (resistive index ≥0.9), low‐resistance flow (resistive index ≤0.5), increased flow velocity (peak systolic velocity ≥137.5 cm/second), or no flow signal. On MR angiography, stenosis and occlusion were defined as >50% narrowing and absent flow signals, respectively. The sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were calculated.ResultsSixty of 364 vertebral arteries (16.5%) had V2 Doppler abnormalities, while 89 vertebrobasilar arteries (24.5%) had a stenosis or occlusion. The Doppler abnormalities predicted any stenosis or occlusion in the vertebrobasilar artery with a sensitivity of 56.2% and specificity of 96.4% (PPV, 83.3%; NPV, 87.2%). The hypoplastic vertebral artery (lumen diameter ≤2.7 mm) was more frequently associated with vertebrobasilar stenosis or occlusion, and with abnormal Doppler spectra (mostly high‐resistance flow), even when it was nonstenotic, than the normal‐diameter vertebral artery (p < .001, chi‐square test).Conclusions: The low sensitivity seems to be due to the high prevalence of non‐V2 lesions not detected on V2 Doppler imaging, suggesting the necessity for a more extensive sonographic examination beyond V2. However, PPV and NPV ≥80% may suggest its usefulness in clinical practice.
Post‐traumatic stress, prevalence of temporomandibular disorders in war veterans: Systematic review with meta‐analysis
Authors: Minervini Giuseppe , Franco Rocco , Marrapodi Maria Maddalena , Fiorillo Luca , Cervino Gabriele , Cicciù Marco 
Published: June 2023

AbstractIntroductionThe physical and psychological effects of war are not always easy to detect, but they can be far‐reaching and long‐lasting. One of the physical effects that may result from war stress is temporomandibular disorder (TMD).ObjectiveTo evaluate the prevalence of TMD sign and symptoms among war veterans diagnosed with PTSD.MethodsWe systematically searched in Web of Science, PubMed and Lilacs for articles published from the inception until 30 December 2022. All documents were assessed for eligibility based on the following Population, Exposure, Comparator and Outcomes (PECO) model: (P) Participants consisted of human subjects. (E) The Exposure consisted of exposition to war. (C) The Comparison was between war veterans (subjects exposed to war) and subjects not exposed to war. (O) The Outcome consisted of presence of temporomandibular disorders sign or symptoms (we considered pain to muscle palpation in war veterans).ResultsForty studies were identified at the end of the research. We chose only four study to draw up the present systematic study. The included subjects were 596. Among them, 274 were exposed to war, whereas the remaining 322 were not exposed to war stress. Among those exposed to war, 154 presented sign/symptoms of TMD (56.2%) whereas only 65 of those not exposed to war (20.18%). The overall effect revealed that subjects exposed to war and diagnosed with PTSD had a higher prevalence of TMD signs (pain at muscle palpation) than controls (RR 2.21; 95% CI: 1.13–4.34), showing an association PTSD war‐related and TMD.ConclusionsWar can cause lasting physical and psychological damage that can lead to chronic diseases. Our results clearly demonstrated that war exposure, directly or indirectly, increases the risk of developing TMJ dysfunction and TMD sign/symptoms.
Where digital meets physical innovation: Reverse salients and the unrealized dreams of3Dprinting
Authors: Rayna Thierry , West Joel 
Published: June 2023

AbstractFor more than three decades, enthusiasts have predicted that direct manufacturing enabled by 3D printing would inevitably supplant traditional manufacturing methods. Alas, for nearly as long, these utopian predictions have failed to materialize. One reason is a flawed assumption that hybrid digital‐physical systems such as 3D printing would advance as rapidly as purely digital innovations enabled by Moore's law. Instead, like other examples of cyber‐physical systems (CPSs), technological progress in 3D printing faces inherent limitations that are emblematic of the differences between CPSs and purely digital innovations. As with any complex CPS, improved performance of a 3D printing system has been limited by that of its key components—the sort of limiting problem previously defined as a reverse salient. Unlike previously studied technologies, several reverse salients for 3D printing performance have neither resolved nor signs of resolving soon. Here we analyze these key reverse salients, and show how they have hampered the suitability of 3D printing for direct manufacturing and other predicted applications. We contrast predicted versus actual capabilities for 3D printing‐enabled transformation in six key areas: product innovation, mass customization, home fabrication, distributed manufacturing, supply chain optimization and business model innovation. From this, we suggest opportunities for greater realism in future 3D printing research, as well as broader implications for our understanding of CPSs and reverse salients.
Video brochures in a mailed fecal immunochemical test outreach program provide cancer screening information in a user‐friendly format for rural Appalachian community members
Authors: Katz Mira L. , Shoben Abigail B. , Newell Sabrina , Hall Christina , Emerson Brent , Gray Darrell M. , Chakraborty Subhankar , Reiter Paul L. 
Published: June 2023

AbstractPurposeColorectal cancer (CRC) screening is recommended for average‐risk adults, yet many adults are not up‐to‐date with screening. One recommended CRC screening approach is the annual completion of a fecal immunochemical test (FIT). However, usually, fewer than half of mailed FIT tests are returned.MethodsTo address barriers to FIT return, a video brochure was developed providing targeted CRC screening information and step‐by‐step FIT instructions as a component in a mailed FIT program. This pilot study occurred in 2021‐2022 and partnered with a federally qualified health center in Appalachian Ohio to send a FIT to patients who were 50‐64 years old, of average risk, and not up‐to‐date on CRC screening. Patients were randomly assigned to 1 of 3 groups that differed on materials sent with the FIT: usual care (manufacturer's instructions), a video brochure (video instructions, disposable gloves, disposable stool collection device), or an audio brochure (audio instructions, disposable gloves, disposable stool collection device).FindingsOverall, 16 of 94 patients (17%) returned the FIT, and return was higher among those sent the video brochure (28%) compared to the other 2 groups (OR: 3.1; 95% CI: 1.02, 9.2;P= .046). Two patients had positive tests and were referred for colonoscopy. Patients sent the video brochure reported the content was important, relevant, and made them think about completing the FIT.ConclusionsUsing a video brochure to provide understandable information in a mailed FIT kit is a promising strategy to improve CRC screening outreach programs in rural regions.
A feature extraction and deep learning approach for network traffic volume prediction considering detector reliability
Authors: Zou Xiexin , Chung Edward , Zhou Yue , Long Meng , Lam William H. K. 
Published: June 2023

AbstractAccurate traffic volume prediction plays a crucial role in urban traffic control by relieving congestion through improved regulation of traffic volume. Network‐level traffic volume prediction and detector failure have rarely been considered in the literature. This paper proposes a framework based on long short‐term memory and the multilayer perceptron that can predict network‐level traffic volumes even with detector failure. A profile model learns the profile of the detector's signature (traffic pattern). Detectors with similar profiles are considered to have similar traffic patterns and are grouped into a cluster. Failed detectors can obtain reference information from similar detectors in the same cluster without additional information. A predictive model is developed for each cluster. The proposed method is validated using Japan Road Traffic Information Center data for three cities. The computational results indicate that the proposed method performs well both on typical days and atypical days (the COVID‐19 lockdown period and the 2021 Tokyo Olympics). Further, it considers detector reliability: the increase in mean absolute error is less than 1 veh/5 min when the probability of detector failure increases to 20%.
Evaluation of effects of brackets and orthodontic wires on intraoral scans: A prospective in‐vivo study
Authors: Palone Mario , Bellavia Marco , Floris Matteo , Rombolà Andrea , Cremonini Francesca , Albertini Paolo , Lombardo Luca 
Published: June 2023

AbstractObjectiveTo evaluate any distortion produced by multibracket fixed orthodontic appliances on digital models obtained from intraoral scans (IOS), considering the presence of both brackets only and brackets/archwire combination.Setting/SampleThe IOS data of the arches of 20 patients (12 females and 8 males; mean age = 15.55 ± 2.84 years) were acquired using the CS3600 intraoral scanner (Carestream Dental, Atlanta, USA), without any appliances (model A), with vestibular brackets alone (model B) and then with brackets and orthodontic archwire fitted (model C).Materials and MethodsData were acquired between the months of January and October 2021 at the moment of indirect bonding phase. On each model, five intra‐arch linear measurements were obtained (inter‐canine, inter‐premolar 1 and 2, inter‐molar and arch depth), and after digital matching between model A and B (match 1) and A and C (match 2), the linear discrepancies were evaluated at 20 points (10 occlusal and 10 gingivolingual) previous identified on the reference model A. All measurements were performed using Geomagic Control X software (3D Systems, Morrisville, USA), and any dimensional variations and distortions were evaluated by the linear regression analysis and two‐sample t‐test (P ≤ .05).ResultsThe results show an almost perfect correlation between both models B and C and the reference model A, both as regards the intra‐arch linear measurements and the linear discrepancies found at the 20 identified points.ConclusionsMultibracket fixed orthodontic appliances do not produce any relevant distortions in digital models obtained via intraoral scanning. Therefore, the removal of archwire is not mandatory before IOS.
Pediatric anesthetic for tracheobronchial foreign body extraction: A survey of practice in France
Authors: Loreau Chine , Caruselli Marco , Roncin César , Salvi Nadège , Lenoire Alexandre , Allary Chloé , De Queiroz Mathilde , Belghiti‐Alaoui Myriem , Michel Fabrice ,   Association des Anesthésistes Réanimateurs Pédiatriques d'Expression Française (ADARPEF)
Published: June 2023

AbstractBackgroundTracheobronchial foreign body aspiration is a classic pediatric emergency, and its associated morbidity particularly depends on the anesthetic management, which differs according to the center and the practitioner.AimsThe aim of this study was to evaluate the different anesthetic practices for tracheobronchial foreign body extraction.MethodsA survey was sent via email to the member physicians of the Association des Anesthésistes Réanimateurs Pédiatriques d'Expression Française (ADARPEF). The survey included 28 questions about the organizational and anesthetic management of an evolving clinical case.ResultsA total of 151 physicians responded to the survey. Only 13.2% of the respondents reported that their institution had a management protocol, and 21.7% required a computerized tomography scan before the procedure was performed for children who were asymptomatic or mildly symptomatic during the night. There were 56.3% of the respondents who reported that extraction with a rigid bronchoscope is the only procedure usually performed in their institution. Regarding rigid bronchoscopy, 47.0% used combined intravenous‐inhalation anesthesia. The objective was to maintain the child on spontaneous ventilation for 63.6% of the respondents, but anesthesia management differed according to the physician's experience.ConclusionsOur study confirms the diversity of practices concerning anesthetic for tracheobronchial foreign body extraction and found reveal differences in practice according to physician experience.
Outcomes for 41 260 pediatric surgical patients with opioid‐free anesthesia: One center's experience
Authors: Martin Lynn D. , Franz Amber M. , Rampersad Sally E. , Ojo Bukola , Low Daniel K. , Martin Lizabeth D. , Hunyady Agnes I. , Flack Sean H. , Geiduschek Jeremy M. 
Published: June 2023

AbstractBackgroundOpioid use is common and associated with side effects and risks. Consequently, analgesic strategies to reduce opioid utilization have been developed. Regional anesthesia and multimodal strategies are central tenets of enhanced recovery pathways and facilitate reduced perioperative opioid use. Opioid‐free anesthesia (OFA) protocols eliminate all intraoperative opioids, reserving opioids for postoperative rescue treatment. Systematic reviews show variable results for OFA.MethodsIn a series of Quality Improvement (QI) projects, multidisciplinary teams developed interventions to test and spread OFA first in our ambulatory surgery center (ASC) and then in our hospital. Outcome measures were tracked using statistical process control charts to increase the adoption of OFA.ResultsBetween January 1, 2016, and September 30, 2022, 19 872 of 28 574 ASC patients received OFA, increasing from 30% to 98%. Post Anesthesia Care Unit (PACU) maximum pain score, opioid‐rescue rate, and postoperative nausea and vomiting (PONV) treatment all decreased concomitantly. The use of OFA now represents our ambulatory standard practice. Over the same timeframe, the spread of this practice to our hospital led to 21 388 of 64 859 patients undergoing select procedures with OFA, increasing from 15% to 60%. Opioid rescue rate and PONV treatment in PACU decreased while hospital maximum pain scores and length of stay were stable. Two procedural examples with OFA benefits were identified. The use of OFA allowed relaxation of adenotonsillectomy admission criteria, resulting in 52 hospital patient days saved. Transition to OFA for laparoscopic appendectomy occurred concomitantly with a decrease in the mean hospital length of stay from 2.9 to 1.4 days, representing a savings of >500 hospital patient days/year.ConclusionsThese QI projects demonstrated that most pediatric ambulatory and select inpatient surgeries are amenable to OFA techniques which may reduce PONV without worsening pain.
Red or green: Overprinting of the climatic signal in Miocene sediments, South China Sea (IODP Expedition 368, Site U1502)
Authors: Ferré E. C. , Satolli S. , Wu H. , Persaud P. , Çukur D. , Bowden S. A. 
Published: June 2023

AbstractSedimentary beds of alternating red and green colour are commonly interpreted to reflect orbitally‐forced cyclic climatic, syn‐depositional conditions, although colour changes caused by post‐depositional fluids are also documented. Results from IODP Hole U1502A marine sediments in the South China Sea exemplify post‐depositional reducing fluid–rock interactions that locally changed the sediment colour from red to green. Petrographic, rock magnetic and paleomagnetic data on cores show that the red colouration originates from an early, basin‐wide, pervasive diagenetic oxidation event (forming haematite), whereas the green colouration results from subsequent fluid‐driven reduction (forming pyrrhotite‐magnetite). The dense sulfidic stockwork in the basaltic basement underlying these sediments was the likely source of reducing fluids. Drilling deep holes into marine basin basements can thus provide useful information on fluid transfer from the basement to the overlying sedimentary layers.
Menopause and mental health
Authors: Swaminathan Ajay , Lepping Peter , Kumar Geeta 
Published: June 2023

Key content
Studies reveal a high prevalence of mental health issues around the menopause transition.
Menopausal symptoms are influenced by personal and environmental factors.
Beneficial effects of estrogen for menopausal depression have been reported.
An integrated care model for the management of mental health symptoms is recommended.
Evidence‐based management options include considering the impact of lifestyle changes, hormone replacement therapy (HRT) and cognitive behavioural therapy.
Learning objectives
To understand the assessment and management of mental health issues in menopause
To understand the role of lifestyle modifications, HRT and alternatives to HRT in the management of menopause‐related mental health issues
Computed tomographic features of double aortic arch in six dogs
Authors: Shua‐Haim Tomer , Vilaplana Grosso Federico R. , Suarez Fuentes David , Giglio Robson Fortes , Balsa Ingrid , Case J. Brad 
Published: June 2023

AbstractDouble aortic arch (DAA) is a rare, congenital anomaly in small animals, resulting in a complete vascular ring encircling the esophagus and trachea, and subsequent compression of these organs. Few studies have reported utilizing CT angiography (CTA) for diagnosing DAA in dogs; thus, the imaging features are currently lacking in the literature. The objectives of this retrospective, multicenter, descriptive case series were to report the clinical and CTA characteristics of DAA in surgically treated cases. Medical records and CTA images were reviewed. Six juvenile dogs met the inclusion criteria (median age: 4.2 months; range: 2–5 months). The most common clinical signs included chronic regurgitation (100%), decreased body condition (67%), and coughing (50%). Common CTA features of DAA included a dominant left aortic arch (median diameter: 8.1 mm) and minor right aortic arch (median diameter: 4.3 mm; 83%), an aberrant right subclavian artery arising directly from the right aortic arch (83%), segmental esophageal constriction (100%), and variable degrees of dilation cranial to the heart base, and marked tracheal luminal compression (median percent change: –55%; 100%) and leftward curvature of the trachea at the level of the bifurcation of the aortic arches (100%). All dogs underwent successful surgical correction with only minor postoperative complications. Due to the similarity of clinical and imaging characteristics described to that of other forms of vascular ring anomalies (VRA), CTA is vital for the specific diagnosis of DAA in dogs.
Endovascular thrombectomy with or without thrombolysis bridging in patients with acute ischaemic stroke: protocol for a systematic review, meta-analysis of randomised trials and cost-effectiveness analysis
Authors: Morsi Rami Z , Zhang Yuan , Carrión-Penagos Julián , Desai Harsh , Tannous Elie , Kothari Sachin , Khamis Assem M , Darzi Andrea J , Tarabichi Ammar , Bastin Reena , Hneiny Layal , Thind Sonam , Coleman Elisheva , Brorson James R , Mendelson Scott , Mansour Ali , Prabhakaran Shyam , Kass-Hout Tareq 
Published: June 2023

IntroductionCurrent published guidelines and meta-analyses comparing endovascular thrombectomy (EVT) alone versus EVT with bridging intravenous thrombolysis (IVT) suggest that EVT alone is non-inferior to EVT with bridging thrombolysis in achieving favourable functional outcome. Because of this controversy, we aimed to systematically update the evidence and meta-analyse data from randomised trials comparing EVT alone versus EVT with bridging thrombolysis, and performed an economic evaluation comparing both strategies.Methods and analysisWe will conduct a systematic review of randomised controlled trials comparing EVT with or without bridging thrombolysis in patients presenting with large vessel occlusions. We will identify eligible studies by systematically searching the following databases from inception without any language restrictions: MEDLINE (through Ovid), Embase and the Cochrane Library. The following criteria will be used to assess eligibility for inclusion: (1) adult patients ≥18 years old; (2) randomised patients to EVT alone or to EVT with IVT; and (3) measured outcomes, including functional outcomes, at least 90 days after randomisation. Pairs of reviewers will independently screen the identified articles, extract information and assess the risk of bias of eligible studies. We will use the Cochrane Risk-of-Bias tool to evaluate risk of bias. We will also use the Grading of Recommendations, Assessment, Development and Evaluation approach to assess the certainty in evidence for each outcome. We will then perform an economic evaluation based on the extracted data.Ethics and disseminationThis systematic review will not require a research ethics approval because no confidential patient data will be used. We will disseminate our findings by publishing the results in a peer-reviewed journal and via presentation at conferences.PROSPERO registration numberCRD42022315608.