bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hombre-organización. Apuntes desde Erich Fromm para comprender la producción de la subjetividad contemporánea
Authors: Botero Bernal Andrés , Aguirre Román Javier Orlando , Almeyda Sarmiento Juan David 
Published: January 2025

El hombre-organización es un concepto propuesto por Fromm, pero poco trabajado por él o por la teoría psicoanalítica en general; sin embargo, cuando se le interpreta en relación con el resto de la filosofía frommiana, cobra un sentido distinto al de ser una mera referencia en uno de sus ensayos. Por ello, la presente investigación, que parte del método bibliográfico-documental con enfoque hermenéutico, tiene por objetivo demostrar el modo en que dicho concepto se relaciona con el resto del proyecto del psicoanálisis social de Fromm. Para ello, el artículo se divide en tres partes: la primera desarrolla la idea del carácter destructivo y su vínculo con el hombre-organización; la segunda enlaza el mismo concepto con el síndrome de decadencia; y la tercera profundiza en la obediencia incondicional y la manera en que caracteriza el concepto en cuestión. Todo esto permite demostrar cómo el hombre-organización puede ser comprendido como un tipo de subjetividad que surge entre el tránsito del capitalismo fordista tradicional a una nueva comprensión del ser humano como empresa de sí.
Temas coyunturales, desafíos estructurales para la Cooperación Internacional
Authors: Blanco-Rangel Ibelis 
Published: January 2025

Finaliza el 2024, por ello se propone una edición no temática que da cuenta del mundo convulso. Aborda temas tan diferentes como la situación en Ucrania; la migración internacional que recibe India frente de mujeres nepalíes; así como prácticas artísticas, un instrumento de la cooperación internacional por mencionar algunos.
El enfoque epistemológico de cada investigación da cuenta que en medio de la diversidad es posible encontrar un denominador común: los temas coyunturales son un desafío estructural a nivel político, social y económico, en un contexto post pandemia. Por esta razón, invitamos a los lectores a formular interrogantes, a cuestionar los planteamientos formulados e incluso a identificar la relación con otras investigaciones publicadas en nuestra revista.
A Review on Branched-Chain Amino Acid Aminotransferase (BCAT) Inhibitors: Current Status, Challenges and Perspectives
Authors: Zhang Xiansheng , Zhu Xinyuan , Li Yong , Li Yan , Luo Wen , Khan Maaz , Pan Jiamin , Pan Hong , Xie Hua , Zhao Guilong 
Published: January 2025

Abstract:
Branched-chain amino acids (BCAAs) are essential amino acids for humans
and play an indispensable role in many physiological and pathological processes.
Branched-chain amino acid aminotransferase (BCAT) is a key enzyme that catalyzes the
metabolism of BCAAs. BCAT is upregulated in many cancers and implicated in the development
and progress of some other diseases, such as metabolic and neurological diseases;
and therefore, targeting BCAT might be a potential therapeutic approach for these
diseases. There are two isoforms of BCAT, i.e., cytoplasmic BCAT1 (or BCATc) and
mitochondrial BCAT2 (or BCATm). The discovery of BCAT inhibitors was initiated by
Warner-Lambert, a subsidiary of Pfizer, in 2000, followed by many other pharmaceutical
companies, such as GlaxoSmithKline (GSK), Ergon, Icagen, Agios, and Bayer.
Strategies of high-throughput screening (HTS), DNA-Encoded library technology
(ELT), and fragment-based screening (FBS) have been employed for hit identification,
followed by structural optimization. Despite low selectivity, both BCAT1 and BCAT2
selective inhibitors were individually developed, each with a few chemical structural
classes. The most advanced BCAT1 inhibitor is BAY-069, discovered by Bayer, which
has a potent enzymatic inhibitory activity against BCAT1 and a decent in vitro and in
vivo pharmacokinetic profile but displayed weaker cellular inhibitory activity and almost
no anti-proliferative activity. There are no BCAT inhibitors currently under investigation
in clinical trials. Further studies are still needed to discover BCAT inhibitors with
a more druggable profile for proof of concept. This review focuses on the latest progress
of studies on the understanding of the physiology and pathology of BCAT and the discovery
and development of BCAT inhibitors. The structure-activity relationship (SAR)
and the druggability, and the challenges of BCAT inhibitors are discussed, with the aim
of inspiring the discovery and development of BCAT inhibitors in the future.
RNA Modification and Digestive Tract Tumors: A Review
Authors: Liu Yafeng , Zhang Shujun , Liu Kaijie , Gu Xinyu , Hu Xinjun 
Published: January 2025

Abstract:
Gastrointestinal tumors, including colorectal and liver cancer, are among the
most prevalent and lethal solid tumors. These malignancies are characterized by worsening
prognoses and increasing incidence rates. Traditional therapeutic approaches often
prove ineffective. Recent advancements in high-throughput sequencing and sophisticated
RNA modification detection technologies have uncovered numerous RNA chemical
alterations significantly associated with the pathogenesis of various diseases, notably
cancer. These discoveries have opened new avenues for therapeutic intervention. This article
delves into epigenetic modifications, with a particular emphasis on RNA alterations
such as N6-methyladenosine (m6A), 5-methylcytosine (m5C), 1-methyladenosine
(m1A), 7-methylguanosine (m7G), and N4-acetylcysteine (ac4C). It examines the functions
and mechanisms of action of regulatory entities known as “Writers,” “Readers,”
and “Erasers” to these modifications. Additionally, it outlines various methodologies for
detecting these RNA modifications. Conventional techniques include radioactive isotope
incorporation, two-dimensional thin-layer chromatography (2D-TLC), mass spectrometry,
and immunological detection methods. Specialized methods such as bisulfite sequencing
and reverse transcription stops are also discussed. Furthermore, the article underscores
the significance of these modifications in the development, progression, and
therapeutic targeting of gastrointestinal tumors, including esophageal, gastric, colorectal,
liver, and pancreatic cancers. This exploration provides foundational insights for enhancing
diagnostic accuracy, treatment efficacy, and prognostic assessment in gastrointestinal
oncology.
Decoding a Million Genomes: Unveiling the Protein-Coding Landscape and Its Implications for Precision Medicine
Authors: Zhang Jinwei 
Published: January 2025

Abstract:
The study by Sun et al. , which sequenced exomes from 983,578 individuals, provides
a comprehensive resource on protein-coding genetic variation. This commentary examines the key
findings, including rare biallelic variants and loss-of-function intolerant genes, while emphasizing
their implications for gene splicing, human knockouts, and disease-associated genes. Additionally,
we discuss how these insights propel advancements in precision medicine and suggest future research
directions, particularly in the study of non-coding DNA and regulatory RNAs at population
scales.
An Anticancer Bioactive Peptide Combined with Oxaliplatin Inhibited Gastric Cancer Cells In Vitro and In Vivo
Authors: Li Xian , Kang Lihua , Han Wenyan , Su Xiulan 
Published: January 2025

Background:
Gastric cancer has become one of the major diseases threatening human
health. This study aimed to investigate the mechanism of an anticancer bioactive peptide (ACBP)
combined with oxaliplatin (OXA) on MKN-45, SGC7901, and NCI-N87 differentiated human gastric
cancer cells and GES-1 immortalized human gastric mucosal epithelial cells. The therapeutic
effect and action mechanism of short-term intermittent ACBP combined with OXA on nude mice
with human gastric cancer were also investigated.

Methods:
The half-maximal inhibitory concentrations of these agents in these cells were measured
by an MTT assay, and cell morphological changes were observed by H&E staining. The expression
of Lin28, miR-107, miR-609, and Let-7 in these four cell lines was determined by q-PCR
after drug treatment. Lin28 protein expression in these four cell lines treated with these drugs was
measured by western blotting. Furthermore, activity and quality of life were observed daily in all
tumor-bearing nude mice, and the expression of Lin28 in tumor tissue was determined by immunohistochemistry
and RT-PCR.

Results:
The results showed that ACBP inhibited the proliferation of MKN-45, SGC7901, and
NCI-N87 gastric cancer cells in a dose-dependent manner and weakly suppressed the proliferation
of GES-1 cells. Moreover, its inhibitory effect on proliferation was stronger in poorly differentiated
gastric cancer cells. ACBP, OXA, and the combination upregulated Lin28 gene expression in
MKN-45 cells and downregulated it in SGC7901 and GES-1 cells. ACBP and the combination
therapy downregulated Let-7 expression in MKN-45 cells and upregulated Let-7 expression in
SGC7901 cells. The combination of ACBP with OXA demonstrated significant anticancer sensitization.
Moreover, it also significantly improved the quality of life of tumor-bearing nude mice and
reduced the toxic side effects of chemotherapeutic drugs on nude mice.

Conclusion:
ACBP alone and in combination with oxaliplatin influenced the expression of tumor
stem cell marker gene Lin28 and regulated the expression of microRNAs specifically regulated by
Lin28. In addition, the anticancer effects and attenuated sensitization effects of ACBP may be related
to the Lin28/miRNA-107 signaling pathway, acting by inhibiting the proliferation of cancerous
stem cells. The findings of this study provide a scientific basis for exploring the antitumor
mechanism of ACBP alone and combined with chemotherapeutic drugs.

other:
The completion of this project provides a scientific basis for exploring the antitumor mechanism of ACBP alone and combined with chemotherapeutic drugs.
Nanotechnology-Driven Approaches for Targeted Rectal Microbiome Modulation in Gastrointestinal Disorders
Authors: Dudhat Kiran 
Published: January 2025

Abstract:
The gastrointestinal tract hosts a complex ecosystem of microorganisms, with rectum
playing a critical role in microbial diversity and health. This manuscript provides a comprehensive
overview of rectal microbes, their functions, and the latest technological advancements in studying
and manipulating these microorganisms for therapeutic purposes. Key microbial phyla in the rectum
include Firmicutes, Bacteroidetes, Actinobacteria, and Proteobacteria, each contributing to essential
functions such as digestion, vitamin synthesis, and immune modulation. The growth mechanisms of
these microbes are influenced by nutrient availability, anaerobic conditions, pH levels, and microbial
interactions. Technological applications like probiotics, fecal microbiota transplantation, microbiome
analysis, and prebiotics are explored for their potential to enhance gut health. Novel treatments
incorporating nanoparticles offer targeted delivery, enhanced bioavailability, and controlled
release of therapeutic agents, paving the way for advanced and personalized interventions in gastrointestinal
medicine. Future directions include personalized medicine, microbiome-host interaction
studies, disease mechanism investigations, and synthetic biology approaches, aiming to harness the
full potential of rectal microbiota for disease prevention and health maintenance.
The Mechanism of 2-Methyl Valeric Acid Inhibiting Virulence Regulator Ser/Thr Phosphatase (Stp1) in Staphylococcus aureus
Authors: Yang Yanan , Gao Yawen , Li Xuenan 
Published: January 2025

Introduction:
Increased resistance of Staphylococcus aureus (S. aureus) poses a significant
threat to disease control in animal husbandry and human public health. Eukaryotic-like Ser / Thr
phosphatase (Stp1) is an effective target for the regulation of bacterial virulence. In this study, potential
Stp1 inhibitors were screened through virtual screening, and the inhibitory mechanism of these
compounds was explored using molecular dynamics simulations.

Methods:
Virtual screening studies were performed using AutoDock vina 4.0 software. The SwissADME
server predicted the properties of chemical absorption, distribution, metabolism, excretion,
and toxicity (ADMET). Molecular dynamics simulation was performed using the Gromacs software
package, and molecular mechanics/generalized Born surface area (MM/GBSA) was calculated using
the Amber 10 package. The inhibition mechanism was verified using phosphatase, mutagenesis, and
fluorescence quenching assays.

Results:
The 2-methylvaleric acid from foods was found to be a competitive inhibitor of Stp1, based
on the kinetics of the enzymatic reaction and virtual screening. Molecular dynamics simulations
revealed that 2-methylvaleric acid binds to the active center of Stp1 and reduces enzyme activity by
competing with its substrate. Interestingly, the molecular modeling and kinetics of the enzymatic
reactions were consistent. Energy decomposition indicated that Met39, Thr102, Ile164, Val167, and
Thr170 played important roles in complex binding. Additionally, the SwissADME server showed
that 2-methylvaleric acid possesses drug-like properties.

Conclusion:
Therefore, 2-methylvaleric acid is a promising compound for further exploration because
of its potential to reduce S. aureus virulence. These findings are conducive to additional discovery
and design of new inhibitors.
Screening of Novel 1,2,4-triazine Clubbed 1,2,3-triazole Derivatives as Α-glucosidase Inhibitors: In Silico Study
Authors: Chaturvedi Neha , Bhattacharya Sushanta , Asati Vivek , Chtita Samir , Kaya Savaş , Almehizia Abdulrahman A. , Dubey Raghvendra 
Published: January 2025

Introduction:
A new set of 1,2,4-triazine combined 1, 2, 3-triazole hybrids were designed
computationally for predicting anti-diabetic potential. All the derivatives taken for study exhibited
excellent anti-diabetic potential with significant IC50 values.

Methods:
The present research includes the development of pharmacophore models, 3D QSAR,
virtual screening, molecular docking, and evaluation of models based on certain criteria. The
DHRRR_1 showed the best pharmacophore model with a survival score of 5.9937. The 3D QSAR
analysis developed a model with the values of R2 = 0.9714 and Q2 = 0.7202. The binding pose and
affinity of the most potent compound, 10c, in the active site of α-glucosidase was investigated using
in-silico molecular docking analysis.

Results:
It was observed that compound 10c demonstrated promising binding affinity with a score of
-8.078 kcal/mol and exhibited binding interaction with the essential amino acids ASN301 and
LEU227. There were five compounds (1-5) that showed significant binding affinity towards the target
comprising active amino acids (ASH202, ASP333 and VAL335). The molecular dynamic study
showed the stability of ligand-protein binding interactions.

Conclusion:
The results of the present investigation can accelerate the optimization and reformation
of the latest anti-diabetic agents that target the α-glucosidase.
Nasal Continuous Positive Airway Pressure versus High-Flow Nasal Cannula for the Treatment of Respiratory Distress Syndrome in Preterm Neonates: A Randomized Controlled Trial
Authors: Aramesh Mohammad Reza , Majidinezjad Sahar , Dehdashtian Masoud , Malakian Arash , Mohammadi Shooka 
Published: January 2025

Background:
There is no consensus regarding the comparison between nasal continuous
positive airway pressure (NCPAP) and high-flow nasal cannula (HFNC) in the treatment of respiratory
distress syndrome (RDS) among premature infants.

Objective:
This randomized controlled trial (RCT) assessed the efficacy of NCPAP compared to
HFNC for the treatment of preterm neonates with RDS.

Methods:
The study was conducted at Imam Hospital (Ahvaz, Iran) among preterm neonates with
RDS and gestational ages ranging from 28 to 34 weeks. One hundred twenty preterm neonates
were randomly allocated to the HFNC or NCPAP groups (n = 60). Demographic and clinical characteristics
were collected.

Results:
This trial was carried out with 51 male and 69 female preterm neonates. There were no
substantial differences between the HFNC and NCPAP groups in gender distribution, occurrence
rates of premature rupture of membranes (PROM), necrotizing enterocolitis (NEC), cardiopulmonary
resuscitation (CPR), Cesarean delivery, patent ductus arteriosus (PDA), intraventricular hemorrhage
(IVH), pneumothorax, chronic lung disease (CLD), treatment failure, and mortality (P >
0.05). The mean body weight, gestational age, Apgar and RDS scores, duration of invasive mechanical
ventilation (IMV), length of oxygen therapy, hospitalization period, duration to reach full
feeding, arterial blood pH, or gas levels were not significantly different between the two groups.
However, the HFNC group exhibited a lower incidence of nasal trauma, required more surfactant
therapy, and had a longer duration of intervention compared to the NCPAP group.

Conclusion:
There were no significant differences between NCPAP and HFNC for the treatment
of RDS in preterm infants.
Anti-neuroinflammatory and Neuroprotective Effects of T-006 on Alzheimer’s Disease Models by Modulating TLR4-Mediated MyD88/ NF-κB Signaling
Authors: Chen Haiyun , Chang Xiao , Zhou Jiemei , Zhang Guiliang , Cheng Jiehong , Zhang Zaijun , Xing Jieyu , Yan Chunyan , Liu Zheng 
Published: January 2025

Introduction:
Neuroinflammation derived from the activation of the microglia is considered
a vital pathogenic factor of Alzheimer's Disease (AD). T-006, a tetramethylpyrazine derivative,
has been found to alleviate cognitive deficits via inhibiting tau expression and phosphorylation in
AD transgenic mouse models. Recently, T-006 has been proven to dramatically decrease the levels
of total Amyloid β (Aβ) peptide and Glial Fibrillary Acidic Protein (GFAP) and suppress the expression
of ionized calcium binding adaptor molecule-1 (Iba-1) in APP/PS1 mice. Therefore, we
have further investigated the effects of T-006 on neuroinflammation in AD-like pathology.

Methods:
The anti-inflammatory effects of T-006 and its underlying mechanisms were evaluated in
Lipopolysaccharide (LPS)-induced AD rats. The potential protective effects against LPS-activated
microglia-mediated neurotoxicity were also measured.

Results:
T-006 significantly improved the cognitive impairment in LPS-induced AD rats by inhibiting
the microglia/astrocyte activation. Further cellular assays found that T-006 significantly reserved
the anomalous elevation of inflammatory cytokines in LPS-induced BV2 microglial cells in a
concentration-dependent manner, while T-006 treatment alone showed no effects on the normal cultured
cells. T-006 also reduced the levels of Toll-like Receptor 4 (TLR4)/Myeloid Differentiation
protein-88 (MyD88)/NF-κB signaling-related proteins in BV2 cells exposed to LPS stimulation.
TAK242, which selectively inhibits TLR4, slightly lessened the effects of T-006 in LPS-treatment
BV2 cells without significance. Importantly, T-006 protected neurons against LPS-induced neuroinflammation
by inhibiting the Reactive Oxygen Species (ROS) production and maintaining mitochondrial
function.

Conclusion:
T-006 inhibited TLR4-mediated MyD88/NF-κB signaling pathways to suppress
neuroinflammation in the LPS-induced AD rat model.
Significance of Serum Magnesium in Parathyroid Hormone Level in Patients with Chronic Kidney Disease
Authors: Wang Jiali , Lin Yongda , Chen Xiutian , Li Hong-Yan , Tang Wenzhuang , Zhou Tianbiao 
Published: January 2025

Introduction:
In chronic kidney disease (CKD) patients, elevated parathyroid hormone
(PTH) is linked to cardiovascular mortality and morbidity. Levels of PTH are influenced by serum
phosphate (P) and calcium (Ca), but little is known about the impact of magnesium (Mg) on PTH.
Hence, this study investigated the relationship between PTH and Mg in peritoneal dialysis (PD) patients
and non-dialysis patients from three hospitals in China.

Material and methods:
This cross-sectional study included 446 chronic kidney disease stage 5
(CKD5) patients from three hospitals in southern China. PTH was naturally transformed to
Ln_PTH for analysis. The chi-square test, Pearson correlation analysis, hierarchical regression
analysis, and t-test were used to explore the relationships between Ln_PTH and gender, diabetes
history, Mg, P, Ca, albumin (Alb), red blood cells (RBC), hemoglobin (Hb), white blood cells (WBC),
and platelet (Plt).

Results:
Patients with diabetes mellitus (DM) had lower levels of Ln_PTH in PD (P<0.05) and
non-dialysis (P>0.05) patients. Ln_PTH levels were negatively associated with Mg and Ca but
positively associated with P and Alb in PD patients (all P<0.05). Ln_PTH levels were negatively
associated with age but positively associated with P in non-dialysis patients (all P<0.05).

Conclusion:
This study demonstrates the negative effect of Mg and diabetes on Ln_PTH levels in
CKD5 patients.
Neonatal Pain Management: Is There An Endocrinal Response?
Authors: Elfarargy Mohamed Shawky , Ahmad Ahmad Roshdy , Elbadry Dalia Hamdy 
Published: January 2025

Abstract:
Neonates exhibit pain responses characterized by various endocrinal changes, including
alterations in cortisone and oxytocin serum levels, as well as physiological and emotional reactions.
The administration of neonatal pain management leads to the normalization of endocrine
hormones, including cortisone and oxytocin, which are affected by the presence of neonatal pain.
Diagnosing neonatal pain is complex; however, effective management is essential. An adequate
balance should be established between the analgesics used for pain management and their associated
side effects. Uncontrolled neonatal pain is correlated with delayed development with increased
neurologic insult. This review aims to examine the significance of neonatal pain, along with its
clinical and physical manifestations. It also explores strategies for managing neonatal pain, encompassing
both pharmacological and non-pharmacological methods, along with the particular medications
utilized in pharmacological interventions. This discussion includes various non-pharmacological
methods for managing neonatal pain. Additionally, this review examines methods for pain assessment.
The aim is to highlight the significance of pain in this vulnerable population and to promote
the implementation of diverse management strategies for neonatal pain to prevent serious yet
avoidable, adverse effects in neonates.
Gut Microbiota and Diabetes: Pioneering New Treatment Frontiers
Authors: Shakya Rupendra , Sivakumar Ponnurengam Malliappan , Prabhakar Pranav Kumar 
Published: January 2025

Abstract:
Diabetes Mellitus (DM) is a complex metabolic disorder characterized by chronic hyperglycemia
and poses significant global health challenges. Conventional treatments, such as insulin
therapy and lifestyle modifications, have shown limited efficacy in addressing the multifactorial
nature of DM. Emerging evidence suggests that gut microbiota, a diverse community of microorganisms
critical for metabolism and immune function, plays a pivotal role in metabolic
health. Dysbiosis, an imbalance in gut microbiota composition, has been linked to insulin resistance,
obesity, and DM. Gut microbiota influences glucose metabolism through mechanisms, including
short-chain fatty acid production, gut permeability regulation, and immune system interactions,
indicating a bidirectional relationship between microbial health and metabolism. Clinical
and experimental studies demonstrate that modulating gut microbiota through dietary interventions
(prebiotics, probiotics, synbiotics) improves glycemic control and insulin sensitivity in DM
patients. Fecal Microbiota Transplantation (FMT) has also shown promise in restoring healthy gut
microbiota and alleviating DM-related metabolic disturbances. However, challenges remain, including
the need for personalized treatments due to individual microbiota variability and the unknown
long-term effects of these interventions. Future research should focus on elucidating the
mechanisms by which gut microbiota influences metabolism and refining personalized approaches
to enhance DM management.