bluuebunny/crossref_metadata_2025_split huggingface dataset:
NEUROMUSCULAR TAPING APPLICATION TO REDUCE WORK-RELATED TENSION NECK SYNDROME IN “BATIK” MANUAL LABOR WORKERS: A PILOT-CONTROLLED TRIAL
Authors: Rahayu Umi Budi , Putriana D. , Setyaningrum A. , Kusumawati Yuli , Blow D. , Romli M. H. 
Published: January 2023

The study aimed to evaluate the effectiveness of NeuroMuscular Taping (NMT) in pain and neck disability in reducing work-related musculoskeletal stress. Methods: This study was conducted on 20 workers, with an age mean of about 53.85 years who work in the home industry of “Batik-Village” in Solo Indonesia that were divided into two groups. Intervention groups ([Formula: see text] = 10) received NMT application, while control groups ([Formula: see text] = 10) received sham treatment by the traditional approach. The collected data covered the Numerical Rating Scale (NRS) for pain and the Neck Disability Index (NDI) for a neck disability. Evaluations were made at four points of time: before, after 3 times, after 6 times of NMT application, and follow-up 15 days after the last application with mirroring duration on the control group. Results: Intervention group showed reduction on pain ([Formula: see text] = 0.000) and neck disability ([Formula: see text] = 0.000) during the intervention but only pain has prolonged effect on follow-up ([Formula: see text] = 0.001). Conclusion: NMT application to painful neck muscles in manual labor workers decreases their subjective sensation of pain during the work, after work, and after the tape removal.
Continuous Scanning and Inching in Ultrasonographic Localisation of Ulnar Neuropathy: A Comparative Study of Sensitivity
Authors: HASHIMOTO Takahiro , IMAJO Yasuaki , FUNABA Masahiro , FUJII Kenzo , YAMAGATA Hiroki , SAKAI Takashi 
Published: January 2023

Background: This study compares the sensitivity of continuous ultrasonographic scanning and ultrasonographic inching in the localisation of ulnar neuropathy at the elbow to diagnose the two common entrapment sites: retroepicondylar groove and cubital tunnel. Methods: The charts of 30 patients who were diagnosed with ulnar neuropathy of the elbow and underwent ultrasonographic examinations using the inching and the continuous technique between April 2015 and September 2019 were reviewed. Sensitivities of ultrasonographic inching and continuous scanning were compared. Results: A total of 34 elbows from 30 patients were examined. The sensitivities of continuous ultrasonographic scanning method and ultrasonographic inching were 85% and 71%, respectively, but this was not significant (p = 0.06). The maximum cross-sectional areas (CSAs) in continuous scanning were mainly found within the area from the medial epicondyle to the 2-cm distal point in the cubital tunnel entrapment, while a majority of the largest CSAs in ultrasonographic inching was observed at the medial epicondyle level in both entrapment sites. The mean of the maximum CSAs in continuous scanning (17.04 ± 6.75 mm2) was higher than that in ultrasonographic inching (14.13 ± 6.63 mm2), although this difference remained non-significant (p = 0.08). However, continuous scanning differed more significantly (p < 0.0001) from the cut-off value than the ultrasonographic inching (p < 0.0066). Conclusions: Continuous scanning might be more suitable than ultrasonographic inching to localise ulnar neuropathy, which inherently has variations in the cubital tunnel anatomy and its entrapment points, when selecting optimal treatment based on the entrapment site. Level of Evidence: Level III (Diagnostic)
Causal Inference for Social and Engineering Systems
Authors: Agarwal Anish 
Published: January 2023

What will happen to Y if we do A? A variety of meaningful social and engineering questions can be formulated this way: What will happen to a patient's health if they are given a new therapy? What will happen to a country's economy if policy-makers legislate a new tax? What will happen to a data center's latency if a new congestion control protocol is used? We explore how to answer such counterfactual questions using observational data-which is increasingly available due to digitization and pervasive sensors-and/or very limited experimental data. The two key challenges are: (i) counterfactual prediction in the presence of latent confounders; (ii) estimation with modern datasets which are high-dimensional, noisy, and sparse.
The key framework we introduce is connecting causal inference with tensor completion. In particular, we represent the various potential outcomes (i.e., counterfactuals) of interest through an order-3 tensor. The key theoretical results presented are: (i) Formal identification results establishing under what missingness patterns, latent confounding, and structure on the tensor is recovery of unobserved potential outcomes possible. (ii) Introducing novel estimators to recover these unobserved potential outcomes and proving they are finite-sample consistent and asymptotically normal.
Finally, we discuss connections between matrix/tensor completion and time series analysis and reinforcement learning; we believe this could serve as a basis to do counterfactual forecasting, and building data-driven simulators for reinforcement learning.
Integrative Single-Cell Analysis Reveals Transcriptional and Epigenetic Regulatory Features of Clear Cell Renal Cell Carcinoma
Authors: Yu Zhenyuan , Lv Yufang , Su Cheng , Lu Wenhao , Zhang RuiRui , Li Jiaping , Guo Bingqian , Yan Haibiao , Liu Deyun , Yang Zhanbin , Mi Hua , Mo Linjian , Guo Yi , Feng Wenyu , Xu Haotian , Peng Wenyi , Cheng Jiwen , Nan Aruo , Mo Zengnan 
Published: January 2023

AbstractClear cell renal cell carcinoma (ccRCC) frequently features a high level of tumor heterogeneity. Elucidating the chromatin landscape of ccRCC at the single-cell level could provide a deeper understanding of the functional states and regulatory dynamics underlying the disease. Here, we performed single-cell RNA sequencing (scRNA-seq) and single-cell assay for transposase-accessible chromatin using sequencing (scATAC-seq) on 19 ccRCC samples, and whole-exome sequencing was used to understand the heterogeneity between individuals. Single-cell transcriptome and chromatin accessibility maps of ccRCC were constructed to reveal the regulatory characteristics of different tumor cell subtypes in ccRCC. Two long noncoding RNAs (RP11-661C8.2 and CTB-164N12.1) were identified that promoted the invasion and migration of ccRCC, which was validated with in vitro experiments. Taken together, this study comprehensively characterized the gene expression and DNA regulation landscape of ccRCC, which could provide new insights into the biology and treatment of ccRCC.Significance:A comprehensive analysis of gene expression and DNA regulation in ccRCC using scATAC-seq and scRNA-seq reveals the DNA regulatory programs of ccRCC at the single-cell level.
LAMC2 Regulates Key Transcriptional and Targetable Effectors to Support Pancreatic Cancer Growth
Authors: Erice Oihane , Narayanan Shruthi , Feliu Iker , Entrialgo-Cadierno Rodrigo , Malinova Antonia , Vicentini Caterina , Guruceaga Elizabeth , Delfino Pietro , Trajkovic-Arsic Marija , Moreno Haritz , Valencia Karmele , Blanco Ester , Macaya Irati , Öhlund Daniel , Khatri Purvesh , Lecanda Fernando , Scarpa Aldo , Siveke Jens T. , Corbo Vincenzo , Ponz-Sarvise Mariano , Vicent Silve 
Published: January 2023

AbstractPurpose:The identification of pancreatic ductal adenocarcinoma (PDAC) dysregulated genes may unveil novel molecular targets entering inhibitory strategies. Laminins are emerging as potential targets in PDAC given their role as diagnostic and prognostic markers. Here, we investigated the cellular, functional, and clinical relevance of LAMC2 and its regulated network, with the ultimate goal of identifying potential therapies.Experimental Design:LAMC2 expression was analyzed in PDAC tissues, a panel of human and mouse cell lines, and a genetically engineered mouse model. Genetic perturbation in 2D, 3D, and in vivo allograft and xenograft models was done. Expression profiling of a LAMC2 network was performed by RNA-sequencing, and publicly available gene expression datasets from experimental and clinical studies examined to query its human relevance. Dual inhibition of pharmacologically targetable LAMC2-regulated effectors was investigated.Results:LAMC2 was consistently upregulated in human and mouse experimental models as well as in human PDAC specimens, and associated with tumor grade and survival. LAMC2 inhibition impaired cell cycle, induced apoptosis, and sensitized PDAC to MEK1/2 inhibitors (MEK1/2i). A LAMC2-regulated network was featured in PDAC, including both classical and quasi-mesenchymal subtypes, and contained downstream effectors transcriptionally shared by the KRAS signaling pathway. LAMC2 regulated a functional FOSL1–AXL axis via AKT phosphorylation. Furthermore, genetic LAMC2 or pharmacological AXL inhibition elicited a synergistic antiproliferative effect in combination with MEK1/2is that was consistent across 2D and 3D human and mouse PDAC models, including primary patient-derived organoids.Conclusions:LAMC2 is a molecular target in PDAC that regulates a transcriptional network that unveils a dual drug combination for cancer treatment.
Parental Factors Affecting Decision to Vaccinate Their Daughters against Human Papillomavirus
Authors: Park Yoon , Ki Moran , Lee Hyunju , Lee Jae-Kwan , Oh Jin-Kyoung 
Published: January 2023

AbstractHuman papillomavirus (HPV) vaccination was introduced in the National Immunization Program (NIP) in Korea targeting girls aged 12 years to receive two doses of HPV vaccine to prevent cervical cancer. This study aimed to evaluate the factors that may influence parental decision to inoculate their daughters in Korea. A cross-sectional survey was conducted in 2020 by interviewing the parents of 2,000 nationally representative girls eligible for HPV NIP. By the daughters’ status of HPV vaccination, the probabilities for each variable were compared with evaluate the factors that could affect parents’ decision to inoculate their daughters with HPV vaccines. Compared with parents who were not vaccinated with HPV, parents who were vaccinated with HPV were 2.40 times more likely to decide to vaccinate their daughters with HPV. Parents who regularly undergo cervical cancer screening were 1.39 times more likely to decide to vaccinate their daughters with HPV than parents who do not receive regular checkups. Parents’ perceived knowledge and perceived risk had a significant impact on their decision to vaccinate their daughters with HPV vaccines. Parents who had strong belief that HPV vaccine is safe in terms of adverse effects were 10 times more likely to decide to vaccinate their daughters against HPV. Parental factors including HPV-related health behavior and awareness were found to be associated with parental decision to vaccinate their daughters against HPV. To improve HPV vaccine uptake at 12 years, it is required to improve parental awareness on HPV through public communication supported by scientific-based evidence.Prevention Relevance:Parental HPV vaccination and maternal regular cervical cancer screening were positively associated with parental decision to vaccinate their daughters against HPV. Parents’ perceived knowledge of HPV vaccination and perceived risk of cervical cancer play an important role in determining whether their 12-year-old daughters will be vaccinated against HPV.
Safety Run-in of Intramuscular pNGVL4a-Sig/E7(detox)/HSP70 DNA and TA-CIN Protein Vaccination as Treatment for HPV16+ ASC-US, ASC-H, or LSIL/CIN1
Authors: Einstein Mark H. , Roden Richard B.S. , Ferrall Louise , Akin Mark , Blomer Allison , Wu T.C. , Chang Yung-Nien 
Published: January 2023

AbstractPatients with human papillomavirus type 16 (HPV16) infection and low-grade cervical dysplasia [low-grade squamous intraepithelial lesion (LSIL)/CIN1] or atypical squamous cells [atypical squamous cells of undetermined significance (ASC-US)/atypical squamous cells- cannot exclude high-grade squamous intraepithelial lesion (ASC-H)] require active surveillance for disease progression. A safe and effective immunotherapy to clear HPV16 is an unmet medical need. The safety run-in cohort of a randomized double-blind, placebo-controlled phase II trial of PVX2 [vaccination twice with HPV16-targeting pNGVL4a-Sig/E7(detox)/HSP70 plasmid and once with the HPV16 L2E7E6 fusion protein “TA-CIN”] as immunotherapy for patients with HPV16+ ASC-US, ASC-H, or LSIL/CIN1 (NCT03911076) was recently completed. The primary objective of this cohort was to determine the safety and tolerability of PVX2 vaccination. Subjects were confirmed to have HPV16 infection and LSIL/CIN1, ASC-US, or ASC-H. Adverse events were evaluated using Common Terminology Criteria for Adverse Events v5.0. HPV typing by HPV16 18/45 Aptima Assay was done at baseline, month 6, and month 12, with simultaneous cytology analysis. Cervical biopsies and endocervical curettage were performed at baseline and month 6. In the safety run-in cohort 12 eligible patients were enrolled. Each received three monthly immunizations. One was lost to follow-up after week 12. There were no serious adverse events. A total of five adverse events were noted by 4 patients; 4 were considered not vaccine-related, and one ‘unlikely related’ by the investigator. At month 6, 45% (5/11) of participants converted to HPV16-negative and 2 others developed CIN2+ and received a loop electrosurgical excision procedure. At month 12, 64% (7/11) were HPV16-negative, including those HPV16-negative at month 6. In conclusion, PVX2 immunotherapy was well tolerated and associated with viral regression, supporting further testing.Prevention Relevance:This safety run-in study cohort suggests that PVX2 immunotherapy is well tolerated in the target population and is sufficiently safe to warrant further clinical testing in a randomized study. The combined vaccines may facilitate higher-than-expected rate of human papillomavirus type 16 viral clearance 6 and 12 months after treatment, although this requires validation.
The effect of the thyristor energy router on harmonics
Authors: Sosnina Elena , Bedretdinov Rustam , Kryukov Evgeny 
Published: January 2023

Energy routers (ER) are the key equipment of the energy internet that provides control over bidirectional power flows and the voltage level of an electric network. The paper presents the thyristor-powered ER (TER) for an Internet-style medium voltage distribution electric network (6, 10, 20 kV). The developed scheme of the device implements longitudinal and transverse voltage regulation at the ER connection point and it allows changing the power flow and the voltage level in the network. The article is devoted to the study of the harmonic components of voltage introduced into the electrical network by the semiconductor elements of the TER. A mathematical and a computer model and a prototype of an electric network section with a TER have been developed. The studies carried out with the help of the developed models have shown that the device does not significantly distort sinusoidally. The harmonic components factor of the output voltage has acceptable values over the entire range of an effective regulation.
Design of optimal PI controller for torque ripple minimization of SVPWM-DTC of BLDC motor
Authors: Kumar Mallempati Sunil , Satheesh Gopisetti , Peddakotla Sujatha 
Published: January 2023

Conventional direct torque control (CDTC) for brushless DC motor (BLDCM) using proportional integral (PI) controller suffers from torque ripple minimization and speed regulation issues. A novel method in fusion with space vector pulse width modulation (SVPWM) with DTC using optimal PI controller is developed to minimize these issues. In this method, SVPWM replaces switching table and hysteresis controllers in CDTC. To get better performance in steady state, conventional PI controllers are preferred in SVPWM-DTC for BLDCM. However, uncertainty arises due to PI controller tuning as well as load variations. In such a case, optimal PI controller tuned properly can minimize these uncertainties. Here, JAYA algorithm is used to tune controller gain parameters. Simulations of proposed PI controller of SVPWM-DTC for BLDCM are carried away in Simulink. To appreciate the performance of proposed optimal controller of SVPWM-DTC for BLDCM, the simulation results are compared with Conventional PI controller and particle swarm optimization (PSO) technique based tuned PI controller. This proposed technique reduces the toque ripple by 63.1% when compared to conventional PI and 58.5% when compared to PSO-PI controller. It also improves the settling time by 43.9% when compared to conventional PI and 46.79% when compared to PSO-PI controller.
Analysis of linear motor with symmetrical EMF vector for household elevator application
Authors: Zuki Nor Aishah Md , Othman Raja Nor Firdaus Kashfi Raja , Shukor Fairul Azhar Abdul , Ahmad Suhairi Rizuan Che 
Published: January 2023

<span lang="EN-US">Linear permanent magnet synchronous motor (LPMSM) has emerged as a viable alternative to other linear motors for higher thrust lifting action. With the advancement of permanent magnets, LPMSM could contribute to energy conversation while also being suitable for applications requiring higher thrust, such as elevator. However, because the existing LPMSM is larger in size, it requires more space to be equipped with a household elevator. To address this issue, a new LPMSM with increased thrust capability has been proposed. The new LPMSM is modelled and analyzed in terms of back EMF and force in this paper. For improved performance, a symmetrical EMF vector is applied to the new LPMSM. In terms of back EMF and force, 4 LPMSM models are studied. According to the results, 6 slot 4 pole has the highest back EMF when compared to the others. As a suitable combination of slot and pole, a symmetrical EMF vector is the suggested LPMSM at the end of this research. </span>
Living with the Virus: Graduate School Students Evaluation of Stressors Related to the Pandemic
Authors: Geronimo Jessica Frey Shane S. , Morada Charmaine M. , Reyes Joseph Niño A. , Zapanta-Ribu Mary Shaira Christa , Vigonte Florinda G. , Malang Bernandino P. , Abante Marmelo V. 
Published: January 2023

The Coronavirus Disease (COVID-19) becomes a global threat in March of 2020. Several countries were on lockdown. It affects health and results in post-traumatic stress disorder (PTSD). During the quarantine and lockdown, the lack of freedom resulted to psychological consequences. In the Philippines, it was March 15, 2020 when the initial COVID-19 was instituted commonly recalled due to lockdown and canceled classes. Filipinos in general and students in particular were worried of their health information including vaccine availability, efficacy, and infection rates. Mental health is impaired by pandemic risks. UNICEF Philippines, then, advocated alternative and continuing learning. The major purpose of this research is to determine graduate students' levels of stress during the COVID-19 outbreak. The descriptive-correlational design was used for the quantitative investigation. The 150 responders are selected at random from Metro Manila master's degree students in the academic year 2022-2023. The adopted questionnaire consists of seven items that are multidimensional scales with psychometric qualities. Using chi-square, the findings revealed that, among demographic profiles, only age showed a significant relationship with the association of global stress. Thus, it can be stated that age is a crucial factor in assessing the global stress of graduate students. COVID-19 is more contagious in adults, reflecting their anxiety and stress during the epidemic.
Seasonal temperature and precipitation regimes drive variation in the wood of oak species (Quercus) along a climatic gradient in western Mexico
Authors: Arenas-Navarro Maribel , Oyama Ken , García-Oliva Felipe , Torres-Miranda Andrés , Terrazas Teresa 
Published: January 2023

Summary
To achieve optimal balance among wood’s support, storage, and transport functions, tree species present adaptive variation in wood anatomical traits. Oaks (Quercus) are woody plants that are dominant in many ecosystems, possess wide variation in wood traits, and can tolerate water stress in diverse habitats. Mountain regions contain steep climatic gradients that exert strong environmental pressures on wood traits. The aims of this study were: (1) to quantify the anatomical variation in 21 oak species distributed along an environmental gradient and (2) to analyze the interspecific variation among the studied species. Fibres and parenchyma fractions were the most abundant cell types. We found a trade-off between total fibre fraction and total parenchyma fraction modulated by the precipitation during the warmest quarter in which oak species in drier areas invested more in support cells. The 21 oak species studied showed vasicentric tracheids, which could be essential to compensate for the transport system in drier areas. Wood density was negatively correlated with the axial parenchyma fraction and fibre lumen width. Oak species have high interspecific variation in the total vessel fraction and vessel diameter. Anatomical variation in oak species along a climatic gradient showed a broad continuum of fibre characteristics from wide to narrow wall and lumen, abundant to scarce parenchyma, and wide to narrow vessels. These variations imply a diversification of ecological strategies within the genus that includes the vascular design of the stem to define the tolerance and competitiveness of the oak species.
Influences of Urbanization on an Afternoon Heavy Rainfall Event over the Yangtze River Delta Region
Authors: Jiang Xiaoling , Zhang Da-Lin , Luo Yali 
Published: January 2023

Abstract
An afternoon heavy rainfall event occurred over coastal Nantong, an area of 70–100 km downstream from the Shanghai–Suzhou–Wuxi–Changzhou city belt over the Yangtze River Delta, under the influences of weak southwesterly monsoonal flows and lake/sea breezes on 26 July 2018. An observational analysis shows the emergence of pronounced urban heat island (UHI) effects along the city belt during the late morning hours. A series of nested-grid cloud-permitting model simulations with the finest grid spacing of 1 km are performed to examine the impacts of urbanization on convection initiation (CI) and the subsequent heavy rainfall event. Results reveal the generation of lake breezes and warm anomalies in the planetary boundary layer along the city belt and low-level convergence, thereby inducing upward motion for CI. The southwesterly flows of the monsoonal warm–moist air, enhanced by the UHI effects along the city belt, allow the development of convective cells along the city belt, some of which merge with convective clusters during their downstream propagation, and the ultimate generation of several distinct heavy rainfall centers by local convective clusters over coastal Nantong where atmospheric columns are more moist and potentially unstable under the influences of sea breezes. Sensitivity simulations show small contribution of Nantong’s UHI effects to the heavy rainfall event. The above findings help elucidate how the UHI effects could assist the CI in a weak-gradient environment, and explain why urbanization can contribute to increased downwind mean and extreme precipitation under the influences of favorable regional forcing conditions.

Significance Statement
The urban heat island (UHI) effects tend to produce more rainfall on its downwind side than that on the other sides, but alone could hardly account for the generation of heavy rainfall. This study examines the influences of the UHI effects associated with a city belt over the Yangtze River Delta on generating an afternoon heavy rainfall event over coastal Nantong that is 70–100 km downwind from the city belt. Results show (i) the downwind advection of the UHI effects; (ii) the initiation of convective storms along the city belt, and their subsequent downstream propagation, leading to the generation of heavy rainfall over Nantong; and (iii) an important role of sea breezes in generating the heavy rainfall event.