bluuebunny/crossref_metadata_2025_split huggingface dataset:
Short and long range 2D 15N-15N NMR correlations among peptide groups by novel solid state dipolar mixing schemes
Authors: Wi Sungsool , Li Conggang , Pham Karen , Lee Woonghee , Frydman Lucio 
Published: July 2023

Abstract
A recently developed homonuclear dipolar recoupling scheme, Adiabatic Linearly FREquency Swept reCOupling (AL FRESCO), was applied to record two-dimensional (2D) 15N-15N correlations on uniformly 15N-labeled GB1 powders. A major feature exploited in these 15N-15N correlations was AL FRESCO’s remarkably low RF power demands, which enabled seconds-long mixing schemes when establishing direct correlations. These 15N-15N mixing schemes proved efficient regardless of the magic-angle spinning (MAS) rate and, being nearly free from dipolar truncation effects, they enabled the detection of long-range, weak dipolar couplings, even in the presence of strong short-range dipolar couplings. This led to a connectivity information that was significantly better than that obtained with spontaneously proton-driven, 15N spin-diffusion experiments. An indirect approach producing long-range 15N-15N correlations was also tested, relying on short (ms-long) 1HN-1HN mixings schemes while applying AL FRESCO chirped pulses along the 15N channel. These indirect mixing schemes produced numerous long-distance Ni-Ni±n (n correlations, that might be useful for characterizing three-dimensional arrangements in proteins. Once again, these AL FRESCO mediated experiments proved more informative than variants based on spin-diffusion-based 1HN-1HN counterparts.
Integrated assessment of susceptibility to shallow landslides and debris flows in watersheds of the Serra do Mar escarpment, southeastern Brazil.
Authors: Vallejo Katerine , Picanço Jefferson 
Published: July 2023

Abstract
Assessing susceptibility to mass movements such as shallow landslides and debris flows, is crucial due to the potential catastrophic consequences when these events reach populated areas. This research proposes an integrated assessment that utilizes three established methods from the literature to evaluate the susceptibility of mass movements. The study area comprises three watersheds selected to be studied using a Digital Terrain Model (DTM), located in the Serra do Mar region in the municipality of Bertioga, State of São Paulo. By adopting this approach, the research aims to predict and map areas susceptible to these natural phenomena in watersheds with no historical record of such occurrences. To assess shallow landslide susceptibility, the Shallow Landsliding Stability Model (SHALSTAB) was employed, considering three different scenarios. The analysis revealed the significant influence of the hydrological parameter of hydraulic conductivity on the results. Furthermore, a morphometric analysis using the Melton Index and Basin Length parameters was utilized to evaluate the susceptibility to debris flows in the studied watersheds. The susceptibility assessment mapping method proposed by the GIDES Project, CPRM/2018 was employed to generate a susceptibility map displaying both critical and dispersion areas of debris flow.
It is essential to assess shallow landslide and debris flow occurrences in prone locations, such as the municipality of Bertioga, to contribute to the existing knowledge by providing updated susceptibility maps and support disaster prevention and territorial planning. The methodology presented here can support decision-making processes, enhance preparedness and response efforts, and contribute to overall improvements in prevention and mitigation of disasters in the Serra do Mar region.
Effect of modified nanosilica on mechanical properties of EPDM/NBR blend-nanocomposites
Authors: K Senthil Nathan , S Krishnamohan , S Vishvanathperumal 
Published: July 2023

AbstractThe modified nanosilica (mNS), acrylonitrile-butadiene rubber (NBR), and ethylene-propylene-diene monomer (EPDM) nanocomposite was created. The 70/30 EPDM/NBR and 0–10 parts per hundred rubber (phr) of mNS were mixed on a two-roll mill. The impact of mNS on compression set, mole percent uptake (MPU), cure characteristics (scorch and optimal cure time, cure rate index, maximum torque, minimum torque, and torque difference) and mechanical properties (tensile and tear strength, hardness, elongation at break, rebound resilience, and abrasion resistance) of the composites were investigated and discussed. The surface morphology of tensile-fractured EPDM/NBR rubber-mNS was investigated using FESEM. The material's tensile strength, 100% modulus, tear strength, hardness, and abrasion resistance were all improved with an increase in mNS concentration, but rebound resilience and elongation at break were decreased.
Arabic Handwritten Character Recognition Using Convolutional Neural Networks
Authors: Alsayed Alhag , Li Chunlin , Fat’hAlalim Ahamed , Abdalsalam Mohammed , Obied Zainab 
Published: July 2023

Abstract
The Arabic language is one of the six most important languages in the world. Because more than 420 million people worldwide use the Arabic script, research into the recognition of Arabic handwriting is crucial. The demand for software that can automatically read and interpret Arabic Handwriting has been rapidly expanding in recent years as the use of digital devices has become increasingly widespread. Characters are written by Hands in Arabic are more difficult to decipher than those noted in English or other languages because of the nature of the words used in Arabic. In this study, we designed a new model, Convolutional Neural Network 14 Layers (CNN-14), to recog-nise handwritten Arabic characters. The The model was trained and tested on the Arabic Handwritten Character Dataset (AHCD) and Hijja datasets, The proposed model achieved good results, with an accuracy of 99.36 per cent in AHCD and 94.35 per cent Hijja dataset.
Family Caregiver experience of caring COVID-19 patients admitted in COVID hospital of B. P. Koirala Institute of Health Sciences, Nepal
Authors: Thapa Prekshya , Lama Sami , Rai Gayatri , Sapkota Nidesh , Pradhan Nirmala , Thapa Roshni , Uprety Pratik , Basnet Madhur 
Published: July 2023

Abstract
Background: Informal caregivers played a substantial role in caring the COVID-19 patients during hospitalization in Nepal. This study attempted to understand the family caregiver’s experiences while attending their relatives in a COVID-19 Hospital of Nepal.
Methods: A descriptive phenomenological approach was used to understand the caregiver’s experience of attending and supporting their relatives admitted to the COVID-19 hospital of B. P. Koirala Institute of Health Sciences.13 caregivers of COVID-19 positive were purposively selected from January to March 2022. A face-to-face interview was conducted in a caregiver residential facility using the interview schedule developed by the department for the purpose of data collection after obtaining ethical clearance from the Institutional review committee of B. Koirala Institute of Health Sciences (B.P.K.I.H.S). Data were audio recorded and manually analyzed.
Results: 13 caregivers (6 male and 7 female) participated in the study. The result was summarized under the five domains: Challenges encountered Changes in Physical and Mental Health, Changes in roles and responsibilities, Positive experiences, and Things that could make Caregiving tasks easier. The major challenges were a financial burden, communication problems, stigmatized attitude, Insecurity and vulnerability, substandard accommodation facility, and visitor restriction policy. A wide range of negative emotions, as well as unmet physical health needs, was reported. Changes in family and occupational roles as a result of the caregiving process cause additional stress to the caregivers. Despite all, they tried to positively cope and adapt to the difficult situation and acknowledged the effort of health personnel and other significant members of the family. Provision of essential medical and basic services/facilities within the hospital, reconstruction of open accommodation facility, maintaining a proper channel of communication, and visitation allowance were suggested as care facilitators to make caregiving tasks easier.
Conclusions:
This study highlights the role of caregivers is very crucial during the time of health crisis.
High-fidelity simulation in healthcare education: Considerations for design, delivery and debriefing.
Authors: Newton Jon 
Published: July 2023

Abstract
Background:
High-Fidelity Simulation (HFS) is a recognised teaching and learning tool and capable of facilitating skill retention and knowledge retrieval. Attitudes, values and behaviours may also be shaped by HFS, fostering a deeper appreciation of the experiential learning cycle as a lifelong learning strategy. Successfully achieving these outcomes relies on effective design, delivery and debriefing.
Methods:
A 3-step debriefing strategy was devised (Trinity Technique) and pilot-tested over a 17-month period. This incorporated a Hot Debrief, a ‘Question and Answer’ session and finally a Cold Debrief (using a newly fashioned tool called STOCK TAKE). The strategy was introduced into the learning of 208 students attached to paramedic science, physician associate, adult nursing and forensic science programmes. Participant feedback was captured in the form of Microsoft Teams transcribes and handwritten notes. Data was evaluated by faculty personnel to instigate refinements to teaching and learning practices.
Findings:
High levels of student and staff engagement were observed. Valuable insight into learner experience was gained and the novel strategy possessed a unique ability to debrief institutions as well as learners - enabling strategic improvements to future HFS design, delivery and debriefing.
Conclusion:
The Trinity Technique demonstrates promise and was effective when applied to interprofessional HFS.
Biosensing with Oleosin-Stabilized Liquid Crystal Droplets
Authors: Honaker Lawrence W. , Eijffius Axel , Plankensteiner Lorenz , Nikiforidis Constantinos V. , Deshpande Siddharth 
Published: July 2023

Abstract
Liquid crystals (LCs) are rapidly emerging as novel platforms for chemical, physical, and biological sensing. With regards to biosensing, LCs can be used to detect amphiphiles such as lipids, fatty acids, digestive surfactants, and bacterial endotoxins. However, designing LC-based sensors in a manner that preserves their sensitivity and responsiveness to these stimuli, and possibly increasing the biocompatibility, remains challenging. In this work, we investigate the stabilization of LC droplets by oleosins, plant-sourced and highly surface active proteins due to their extended amphipathic helix. We show that purified oleosins, at sub-μM concentrations, readily stabilize nematic LC droplets without switching their alignment, allowing them to detect surfactants at μM concentrations. We give direct evidence of the localization of oleosins at the LC-water interface using fluorescent labelling, and show that the stabilized droplets remain stable over months. Interestingly, chiral LC droplets readily switch in the presence of nanomolar oleosin concentrations, an unexpected behavior that we explain by accounting for the energy barriers required for switching the alignment between the two cases. We thus set forth a two-fold conclusion: oleosin-stablized nematic LC droplets present a biocompatible and sustainable alternative for bioanalyte detection, while chiral LCs can be used as highly sensitive and non-invasive sensors for detecting amphipathic helices in biological systems.
Evaluation of Current Trends in Biomedical Applications Using Soft
Computing
Authors: Kumar Sachin , Veer Karan 
Published: July 2023

Abstract:
With the rapid advancement in analyzing high-volume and complex data, machine learning
has become one of the most critical and essential tools for classification and prediction. This study reviews
machine learning (ML) and deep learning (DL) methods for the classification and prediction of
biological signals. The effective utilization of the latest technology in numerous applications, along with
various challenges and possible solutions, is the main objective of this present study. A PICO-based
systematic review is performed to analyze the applications of ML and DL in different biomedical signals,
viz. electroencephalogram (EEG), electromyography (EMG), electrocardiogram (ECG), and wrist
pulse signal from 2015 to 2022. From this analysis, one can measure machine learning's effectiveness
and key characteristics of deep learning. This literature survey finds a clear shift toward deep learning
techniques compared to machine learning used in the classification of biomedical signals.
NOX-2 Inhibitors may be Potential Drug Candidates for the Management
of COVID-19 Complications
Authors: Chowdhury Bimalendu , Sahoo Biswa Mohan , Jena Akankshya Priyadarsani , Hiramani Korikana , Behera Amulyaratna , Acharya Biswajeet 
Published: July 2023

Abstract:
COVID-19 is an RNA virus that attacks the targeting organs, which express angiotensin-
converting enzyme-2 (ACE-2), such as the lungs, heart, renal system, and gastrointestinal
tract. The virus that enters the cell by endocytosis triggers ROS production within the confines of
endosomes via a NOX-2 containing NADPH-oxidase. Various isoforms of NADPH oxidase are
expressed in airways and alveolar epithelial cells, endothelial and vascular smooth muscle cells,
and inflammatory cells, such as alveolar macrophages, monocytes, neutrophils, and Tlymphocytes.
The key NOX isoform expressed in macrophages and neutrophils is the NOX-2 oxidase,
whereas, in airways and alveolar epithelial cells, it appears to be NOX-1 and NOX-2. The
respiratory RNA viruses induce NOX-2-mediated ROS production in the endosomes of alveolar
macrophages. The mitochondrial and NADPH oxidase (NOX) generated ROS can enhance TGF-β
signaling to promote fibrosis of the lungs. The endothelium-derived ROS and platelet-derived
ROS, due to activation of the NADPH-oxidase enzyme, play a crucial role in platelet activation. It
has been observed that NOX-2 is generally activated in COVID-19 patients. The post-COVID
complications like pulmonary fibrosis and platelet aggregation may be due to the activation of
NOX-2. NOX-2 inhibitors may be a useful drug candidate to prevent COVID-19 complications
like pulmonary fibrosis and platelet aggregation.
Peramalan Jumlah Kunjungan Wisatawan Mancanegara ke Provinsi Aceh Menggunakan Fuzzy Time Series Chen
Authors: Fery Andika  , Dayanti Selvy , Dewi Fransiska , Nurviana  
Published: July 2023

Sektor pariwisata memegang peranan penting dalam pertumbuhan ekonomi Indonesia, serta merupakan salah satu sumber penerimaan devisa negara. Provinsi Aceh memiliki potensi besar untuk pengembangan sektor pariwisata. Hal ini ditunjukkan dari jumlah wisatawan mancanegara yang mengalami fluktuasi yang cenderung meningkat selama 10 tahun terakhir. Penelitian ini bertujuan untuk memprediksi jumlah kunjungan wisatawan mancanegara ke provinsi Aceh pada bulan Agustus 2022 berdasarkan data sebelumnya. Data historis yang digunakan adalah data kunjungan wisatawan mancanegara sejak periode bulan Januari 2017 hingga bulan Juli 2022 yang diperoleh dari Badan Pusat Statistik (BPS) Provinsi Aceh. Metode peramalan yang digunakan pada penelitian ini adalah Fuzzy Time Series Chen. Hasil peramalan jumlah kunjungan wisatawan mancanegara ke Provinsi Aceh untuk bulan Agustus 2022 menggunakan fuzzifikasi bulan Juli 2022 dengan hasil peramalan sebesar 446 dengan nilai Mean Squared Error (MSE) sebesar 40,87. Hal ini menunujukkan peningkatan yang signifikan dibanding bulan sebelumnya pada masa pandemi covid-19 dimana tidak terdapat kunjungan wisatawan. Hal ini berdampak positif bagi peningkatan perekonomian Aceh di bidang pariwisata.
Kata kunci: peramalan, wisatawan mancanegara, fuzzy time series chen
Diversity of Fern Species (Pteridophyta) Based on the Height in the Mountain Route to the Galang District of Toli Toli And it’s Development As a Learning Medium
Authors: Susila Komang Abdi 
Published: July 2023

Metode yang digunakan adalah metode survei dimana tehnik pengambilan data menggunakan metode plot tunggal. Plot berukuran 20 m x 20 m pada setiap setasiun pengamatan atau tiap penambahan ketinggian tempat sebanyak 100 m dpl pada jalur pengamatan. Lokasi penelitian ditentukan secara purposive sampling, dan dibagi 9 bagian berdasarkan ketinggian dari ketinggian 500 – 1.300 m dpl. Hasil penelitian yang telah dilakukan pada setiap ketinggian mulai dari ketinggian 500 m dpl, 600 m dpl, 700 m dpl, 800 m dpl, 900 m dpl, 1000 m dpl, 1100 m dpl, 1200 m dpl, dan 1300 m dpl di sepanjang jalur pendakian Gunung Galang Kabupaten Tolitoli, diperoleh 16 jenis tumbuhan paku. Pada ketinggian 500 m dpl indeks keanekaragaman sebesar -1,590311843 ini dikategorikan keanekaragaman jenisnya sedang, pada ketinggian 600 m dpl nilai indeks keanekaragaman sebesar -1,358459538 ini dikategorikan keanekaragaman jenisnya sedang, pada ketinggian 700 m dpl nilai indeks keanekaragaman sebesar -1,094911993 ini dikategorikan keanekaragaman jenisnya sedang, pada ketinggian 800 m dpl nilai indeks keanekaragaman sebesar -1,06245397 ini dikategorikan keanekaragaman jenisnya sedang, pada ketinggian 900 m dpl nilai indeks keanekaragaman sebesar -1,013445907 ini dikategorikan keanekaragaman jenisnya sedang, pada ketinggian 1.000 m dpl nilai indeks keanekaragaman sebesar -1,075604164 ini dikategorikan keanekaragaman jenisnya sedang, pada ketinggian 1.100 m dpl nilai indeks keanekaragaman sebesar -0,9529371 ini dikategorikan keanekaragaman jenisnya rendah, pada ketinggian 1.200 m dpl nilai indeks keanekaragaman sebesar -0,598269589 ini dikategorikan keanekaragaman jenisnya rendah, pada ketinggian 1.300 m dpl nilai indeks keanekaragaman sebesar 0 ini dikategorikan keanekaragaman jenisnya rendah. Berdasarkan penelitian yang telah dilakukan dapat disimpulkan Indeks keanekaragaman tumbuhan paku berdasarkan ketinggian di jalur pendakian Gunung Galang Kabupaten Tolitoli menurun seiring dengan bertambahnya ketinggian tempat dari permukaan laut.
Analysis of the Characteristics of Creative Thinking Students through Mathmatical Posing Problems in terms of Gender Differences
Authors: Hairiyah Hairiyah , Djaeng Maxinus , H.B Usman 
Published: July 2023

The purpose of this research is to obtain the description of the characteristics of creative thinking of female students and male students through mathematical posing problems. This research uses a qualitative approach in form of case studies based on the categories of the creative thinking according to Balka. The research subjects were chosen based on purposive sampling who willing to provide complete information, had an open nature, and were willing to work together. The two subjects were chosen female students (PR) and male students (LK). The result shows that the characteristics of creative thinking through problem posing PR subjects and LK subjects in the categories: (1) fluency that is, PR subjects and LK subjects were able to raise a number of problems regarding the function of representing the information content provided, (2) flexibility namely PR subjects and LK subjects were able to create many problems that lead to the understanding of functions with different categories of functions, (3) novelty, homework subjects and LK subjects were able to raise new problems when the interview at the same time, which are different from the problems raised when working on written task posing problems, and (4) understanding, that is, the PR subject and LK subject were able to make linkages between ideas about function. Based on these categories, it is concluded that both subjects able to think creatively in raising problems from the information provided.
ENGLISH NOUN PHRASES OF NARRATIVE TEXT AND NEWS ARTICLE: A CONTRASTIVE ANALYSIS
Authors: Ardianto Ardik 
Published: July 2023

Noun phrases, in either language in general or English in particular, are one of the pivotal topics in formal linguistics. This paper aimed to contrast the similarities and differences of the patterns of ideational structure and syntactic functions of noun phrases in two different text genres. It employed systemic functional linguistic approach using both Ideational structure analysis and syntactical analysis of noun phrases in narrative texts and news articles. The findings of this study show that noun phrases in narrative texts tend to be shorter and simpler, especially as they occupy the subject and object functions. The forms of pre-modifiers used also tend to be simpler (ranging from the use of one or two pre-modifiers only). The same case occurs in post-modifier forms as well. In contrast, news articles tend to use complex phrase structures (two or even three pre-modifiers at once) which are coupled with other complex information in the post-modifiers. Appositives appear several times as post-modifiers to complete the information in the noun phrases. In conclusion, these differences prove that the determinism of writing style in each genre has a significant share in determining the pattern complexity of the noun phrase structures therein.
Clinical and laboratory features of viral lower respiratory tract infections in children
Authors: Orlova E. D. , Babachenko I. V. , Tian N. S. , Kozyrev E. A. , Alekseeva L. A. 
Published: July 2023

Purpose: to give a comparative characteristic of the clinical and laboratory manifestations of viral lower respiratory tract infections of various etiologies.Object and methods: Medical information of 385 patients, who were hospitalized in the clinic of Pediatric Research and Clinical Center for Infectious Diseases in the period from 2016 to 2022, was retrospectively analyzed. Inclusion criteria: age from 1 month to 17 years; infectious diseases of the lower respiratory tract; extraction of respiratory viral nucleic acids in nasopharyngeal swabs by polymerase chain reaction. Upon admission, all children underwent: a physical examination, an examination by an otorhinolaryngologist, a complete blood test with a leucogram, determination of the level of C-reactive protein, and, if it necessary, a chest X-ray in two projections.Results: Respiratory syncytial virus and rhinovirus dominated in the etiological structure of lower respiratory tract infection. Differences in the duration and severity of fever and manifestations of catarrhal syndrome in respiratory viral infections of various etiologies were established. Boca-virus and rhinovirus infections often caused severe damage of the lower respiratory tract with acute respiratory failure. Viral lower respiratory tract infections have such changes in the leucogram as an increase in neutrophils and band cells, which persist for 4-5 days of the disease. The severity of inflammatory changes in the haemogram depends on the etiology of the disease. The most significant changes, such as leukocytosis and an increase in the absolute count of neutrophils, were detected in adenovirus and rhinovirus infections.Conclusion: There were age and clinical features of viral lower respiratory tract infections in children. Prolonged fever and identified inflammatory changes in the hemogram, often in combination with an increase in the level of C-reactive protein, in children with viral lesions of the lower respiratory tract explain the frequency of prescribing antibacterial drugs at any stage of medical care. To select the optimal therapy tactics, it is necessary to take into account the clinical and laboratory features of respiratory viral infections in patients with diseases of the lower respiratory tract.