bluuebunny/crossref_metadata_2025_split huggingface dataset:
Towards Comparative Internet Studies: Internet Service Providers in Japan and China
Authors: Wu Shuxi 
Published: June 2023

Abstract
This article describes comparative internet studies as a useful paradigm through which to study Asian internet(s). It defines comparative internet studies as the systemic comparison of how material and immaterial internet infrastructure developed historically in different countries. This approach has the explicit aim of theoretical intervention and is located at the intersection of three strands of literature: internet studies, infrastructure studies, and regionality. This article brings together these three bodies of literature to illuminate areas of complementarity and cross-semination and to demonstrate how they contribute to a comparative internet studies project that is useful for grappling with Asian internet(s). Then, to illustrate how a comparative internet studies project can be realized, it draws on the author’s prior work on two internet service provider (ISP) projects: i-mode in Japan and Monternet in China.
Digital Vietnam: State of the ‘State of the Field’, Saigonese Motorbike YouTubers, and Diasporic Vietnamese Social Memories of the Republic of Việt Nam
Authors: Bùi Alvin Khiêm 
Published: June 2023

Abstract
This article employs two approaches to characterize the nascent field of research on digital Vietnam. I first analyze the source base and methodologies in state of the field essays about Vietnam. I then turn to digital autoethnography to weave my academic journey with digital Vietnam studies and resources that I encountered along the way. In the second half, I use a case study from an emerging genre in YouTube videos uploaded by Saigonese motorbikers. These motorbikers not only provide a record of the city today that can offer points of entry for social-scientific studies of contemporary Hồ Chí Minh City but also helps historians and members of the Vietnamese diaspora alike to identify histories and memories of a Sài Gòn of the past.
Confucianism and Public Political Discussion
Authors: Mang Franz 
Published: June 2023

Abstract
What role, if any, should Confucianism play in the politics of our time? In some of my previous works, I claimed that modern liberal states should not seek to promote Confucian values on the basis of their intrinsic merits. Yet, drawing insights from Joseph Chan’s moderate state perfectionism and John Rawls’s wide view of public political culture, I proposed the “wide view of moderate perfectionism.” According to this view, in public political discussion, citizens should be allowed to deliberate whether and how Confucianism, among other reasonable moral doctrines, can make positive contributions to their social and political thinking and public policymaking, provided that certain conditions are met. This view has been criticized by some scholars, in particular Zhuoyao Li. Li argues that the practice of the wide view of moderate perfectionism would inevitably harm civility. In this article, I clarify and develop the wide view, and respond to Li’s criticisms.
Amphibians and reptiles in North Sweden: distribution, habitat affinities, and abundance (Classes: Amphibia and Reptilia)
Authors: ELMBERG JOHAN 
Published: June 2023

North Sweden (‘Norrland’ in Swedish) covers 243 000 km2 and lies mainly in the boreal biome. The herpetofauna comprises five amphibian and four reptile species: Lissotriton vulgaris, Triturus cristatus, Bufo bufo, Rana temporaria, Rana arvalis, Zootoca vivipara, Anguis fragilis, Natrix natrix, and Vipera berus.
Successful conservation and management of amphibians and reptiles depend on accurate information about distribution, habitat affinities, and abundance. Such knowledge is also essential as a benchmark to assess changes in distribution and abundance that may come about as a result of climate change and human habitat alteration.
This paper aims to present accurate distribution maps, describe habitat affinities, and provide abundance estimates for the herpetofauna of North Sweden for the period 1970–2022. Distribution data are presented by traditional faunistic provinces, as well as by biotic regions and alpine life zones. Separate sections address post-glacial colonization and a herpetological perspective on anthropogenic changes in relation to species´ present status.
Bufo bufo, Rana temporaria, Rana arvalis, Zootoca vivipara, and Vipera berus are widely distributed throughout the boreal sub-regions. Rana temporaria, Zootoca vivipara, and Vipera berus also extend into the alpine region. Triturus cristatus, Anguis fragilis, and Natrix natrix occur mainly in the coastal parts of the Southern Boreal region. There are no signs of recent changes in distribution range, but Lissotriton vulgaris, Triturus cristatus, and Rana arvalis have been largely overlooked in the past and have a much wider occurrence than previously recognized. Most species are found in habitats usually not described in all-European field guides. Nearly all anurans hibernate in water. Abundance estimates suggest that some species are more common in the boreal than thought, supporting the notion that a large share of their total European population occurs there. Although local extinctions and declines are known, there are no signs of widespread population decline for any species during the study period.
Rumination Moderates the Association between Neuroticism, Anxiety and Depressive Symptoms in Indian Women
Authors: Singh Parwinder , Mishra Navneet 
Published: June 2023

Background: The higher prevalence of depressive symptoms among women demands an in-depth exploration of every possible mechanism through which depressive symptoms may prevail. Identifying any malleable mechanism may open a new pathway through which such symptoms could be targeted. We explored the association between neuroticism, rumination, anxiety, and depressive symptoms and tested a moderated mediation model with anxiety as a mediator in the relationship between neuroticism and depressive symptoms, and rumination as a moderator of the effect of neuroticism on anxiety. Method: This cross-sectional study was conducted on Indian women living in the state of Punjab. A total of 671 adult females responded to the translated versions of standardized questionnaires measuring the relevant constructs. Results: The mean (SD) age of the sample was 23.71 (6.09) years. As hypothesized, anxiety significantly mediated the relationship between neuroticism and depression, and the use of rumination moderated the effect of neuroticism on anxiety. Among women with a high score on neuroticism, those with low ruminating tendencies showed less anxiety and depression than others who scored high on rumination. Conclusion: The findings imply that a reduction in rumination may help women, especially those who are high on neuroticism, manage their vulnerabilities toward anxiety and depressive symptoms. Personality traits being not that malleable, targeting a reduction of rumination usage, which is both a trans-diagnostic factor and a malleable one, can help address the surging prevalence of common mental disorders such as anxiety and depression through appropriately devised interventions.
Effect of Virtual Reality on Sleep-Deprived Individuals
Authors: Chitra Jeba , Eremita Marissa De Souza 
Published: June 2023

Background: Sleep deprivation (SD) refers to getting less than the required amount of sleep, which for adults ranges from 7 to 9 h of sleep per night and can be caused by social and biological factors. College students experience SD, which can affect their academic performance, health, and mood. Virtual Reality Therapy (VRT), an upcoming method of intervention, has been used in other psychological conditions with positive outcomes. The purpose of this study was to determine the effect of VRT on individuals with SD. Methods: This quasi-experimental study recruited 28 individuals based on the scores of the Pittsburgh Sleep Quality Index (PSQI), Athens Insomnia Scale, and Beck’s Depression Inventory, which were used as the inclusion and exclusion criteria. VRT sessions of 20 min were given twice a week for 2 weeks. PSQI was also used as an outcome measure, immediately and 2 weeks after the intervention Results: A significant difference was found between the baseline and post-intervention PSQI scores ( p = 0.001, effect size = 1.2). There was not much difference between the PSQI scores immediately and 2 weeks after the intervention. Conclusion: VRT was effective in improving sleep in individuals with SD.
The COVID-19 Crisis, National Innovation Systems, and World Development
Authors: Lundvall Bengt-Åke 
Published: June 2023

In this think-piece, I reflect on what lessons innovation scholars and innovation policymakers in the developing world can draw from the COVID-19 crisis. While it has confirmed the fundamental importance of science and technology in coping with a major global challenge, it has also shown its limitations and the importance of institutions and organisational capabilities. While the crisis has demonstrated the necessity to build stronger national innovation systems (NSI) in the South, it has also simultaneously shown the need to go beyond national governance and move in the direction of a global innovation system.  The COVID-19 crisis has reinforced new trends in technology and in global competition that challenge innovation system theory and innovation policy. The crisis stimulated the application and development of artificial intelligence and accelerated the concentration of intellectual capital in a handful of tech giants located in the US and China. While the volume of trade in digital services kept growing, there was a dramatic fall in the volume of global value chain trade in tangibles. These developments intensified the China-US rivalry and undermined transnational collaborations in science and technology.  Countries in the South aiming at building stronger national innovation systems need to do so under new circumstances, where artificial intelligence is emerging as a strategic technology, where intellectual monopolies harvest data worldwide, where great powers are engaged in technological rivalry, and where linking up with global value chains for tangibles has become less of an option. One implication is that the issue of scale has become more critical than before; groupings of small and medium-sized countries need to integrate economically and politically in order to develop crucial digital capabilities and competitiveness. Such moves in the direction of forming transnational innovation systems are consonant with strategies to cope with global challenges.
Outcomes of standalone ab interno trabeculotomy in the treatment of open-angle glaucoma in eyes with high myopia
Authors: Yoshida Takeshi , Nomura Takuhei , Yoshimoto Sota , Ohno Motohisa , Ito Taiju , Horie Shintaro , Ohno-Matsui Kyoko 
Published: June 2023

Abstract
Background
We retrospectively evaluate the long-term efficacy and safety of trabeculotomy glaucoma surgery in treating open-angle glaucoma (OAG) in eyes with high myopia (HM).

Methods
This study included 20 eyes with HM (axial length ≥ 26.5 mm) and OAG; age, preoperative IOP (intraocular pressure), and sex-matched 20 non-HM eyes (axial length < 26.5 mm) served as controls. Each eye underwent standalone ab interno trabeculotomy using a Kahook dual blade. A follow-up examination was performed 36 months after surgery. The main outcome measure was the operative success rate (i.e., a ≥ 20% pre- to post-operative reduction in IOP with or without IOP-lowering medication). Kaplan–Meier analysis was employed as a measure of surgical success. The secondary outcome measures were postoperative IOP, the number of glaucoma medications, and postoperative complications.

Results
IOP and the number of glaucoma medications were statistically significantly reduced at all postoperative follow-up examinations. The Kaplan–Meier analysis demonstrated that the probability of postoperative success at 36 months was 45% and 65% for HM and non-HM eyes, respectively. In the HM group, the presence of pathological myopia was statistically significant risk factor for surgical failure. No critical postoperative complications were detected.

Conclusions
In our study, the long-term efficacy of ab interno trabeculotomy in HM eyes with OAG was inferior to that in non-HM eyes with OAG. Our findings suggest that surgical indications for trabeculotomy in HM should be determined based on the presence of pathological myopia.
The short-term effects of blood donation on the ocular parameters including blood flow of the retina and choroid in healthy people using OCT- angiography
Authors: Yu Mengmeng , Sun Xiaolei , Zeng Fanxing , Gao Xiang , Li Zhenzhen , Yuan Gongqiang , Wang Ting 
Published: June 2023

Abstract
Background
To investigate the short-term effects of blood donation on the morphology and blood flow of the retina and choroid in healthy people using optical coherence tomography angiography (OCTA).

Methods
Twenty-eight healthy blood donors (56 eyes) who participated in the 200 ml voluntary blood donation between March 2, 2021 and January 20, 2022 were included. The best corrected visual acuity (BCVA), systolic (SBP) and diastolic blood pressure (DBP), intraocular pressure (IOP), subfoveal choroid thickness (SFCT), retinal thickness (RT), retinal superficial vascular density (SVD), deep vascular density (DVD) and foveal avascular were a (FAZ) were measured and statistically analysed 10 min before, 30 min and 24 h after the blood donation.

Results
The 200 ml blood donation could cause significant IOP reduction at 24 h (P = 0.006), which was negatively correlated with SBP (r = -0.268, P = 0.046), while SBP, DBP, or ocular perfusion pressure were not affected (> 0.05). Moreover, no significant difference existed in the OCT and OCTA indexes, including SFCT, RT, SVD, DVD, and FAZ, before and after the 200 ml blood donation (P > 0.05). The visual acuity was not affected either (P > 0.05).

Conclusions
The 200 ml blood donation was noted to be associated with statistically significant IOP reduction at 24 h, while SBP, DBP, or OPP was not affected. The blood flow of the retina and choroid or the visual acuity did not change significantly after the blood donation. Larger studies with different volumes of blood donation were needed to further analysis the effect of blood donation on ocular parameters.
Downregulation of Claudin5 promotes malignant progression and radioresistance through Beclin1-mediated autophagy in esophageal squamous cell carcinoma
Authors: Huang Shan , Zhang Jiayi , Li Yi , Xu Yaqiong , Jia Hui , An Lei , Wang Xiaotan , Yang Yuting 
Published: June 2023

Abstract
Background
Esophageal squamous cell carcinoma (ESCC) is a highly prevalent and aggressive cancer with poor treatment outcomes. Despite the critical role of tight junction proteins in tumorigenesis, the involvement of Claudin5 in ESCC remains poorly understood. Thus, this study aimed to investigate the role of Claudin5 in ESCC malignant progression and radioresistance, as well as the underlying regulatory mechanisms.

Methods
The expression of Claudin5 was evaluated in esophageal cancer tissue using both public databases and 123 clinical samples. CCK-8, transwell invasion, wound healing and clonogenic survival assays were used to examine the proliferation, invasion, migration and radiosensitivity of ESCC cells in vitro. Xenograft and animal lung metastasis experiments were conducted to examine the impact of Claudin5 on tumor growth and lung metastasis in vivo. The effect of Claudin5 on autophagy was detected via transmission electron microscopy, western blotting and autophagy flux. Immunohistochemical staining was used to detect Claudin5 expression in ESCC patient samples. The statistical difference was assessed with Student t test or one-way ANOVA. The correlation between Claudin5 expression and radiotherapy response rate was performed by the Chi-square test. The significance of Kaplan–Meier curves was evaluated by the Logrank test.

Results
Claudin5 expression was downregulated in ESCC tissues. Downregulation of Claudin5 promoted ESCC cell proliferation, invasion, and migration both in vitro and in vivo. Downregulation of Claudin5 decreased the radiosensitivity of ESCC cells. Moreover, downregulation of Claudin5 promoted autophagy and the expression of Beclin1. Beclin1 knockdown reversed the effect of Claudin5 downregulation on autophagy induction and the promotion of ESCC cell malignant progression and radioresistance. Additionally, low expression of Claudin5 in ESCC cancer tissues was associated with poor radiotherapy response and prognosis.

Conclusions
In summary, these findings suggest that downregulation of Claudin5 promotes ESCC malignant progression and radioresistance via Beclin1-autophagy activation and may serve as a promising biomarker for predicting radiotherapy response and patient outcome in ESCC.
Study on the effect of internet plus continuous nursing on functional recovery and medication compliance of patients with knee joint replacement
Authors: Li Yan , Gu Zongyun , Ning Rende , Yin Hao 
Published: June 2023

Abstract
Objective
To evaluate the effect of "Internet + " continuity of care on postoperative functional recovery and medication compliance in patients with knee arthroplasty.

Methods
In this retrospective study, 100 patients who underwent knee replacement in our hospital between January 2021 and December 2022 were recruited and assigned to receive routine care (routine group) or "Internet + " continuity of care (continuity group), with 50 patients in each group. Outcome measures included knee function, sleep quality, emotional state, medication compliance, and self-care ability.

Results
Patients in the continuity group showed better knee function after discharge and during follow-up versus those in the routine group (P < 0.05). Continuity care resulted in significantly lower Pittsburgh Sleep Quality Index (PSQI), Self-Rating Anxiety Scale (SAS), and Self-Rating Depression Scale (SDS) scores versus routine care (P < 0.05). Patients in the continuity group showed higher treatment compliance, ability of daily living (ADL) scores, and nursing satisfaction than those in the routine group (P < 0.05).

Conclusion
The "Internet + " continuity of care is highly feasible and can effectively promote the postoperative functional recovery of knee replacement patients, improve patients' medication compliance, sleep quality, and self-care ability, mitigate negative emotions, and provide enhanced home care.
Point-of-Care-ultrasound in undergraduate medical education: a scoping review of assessment methods
Authors: DeBiasio Celina , Pageau Paul , Shefrin Allan , Woo Michael Y. , Cheung Warren J. 
Published: June 2023

Abstract
Background
Point-of-Care-Ultrasound (POCUS) curricula have rapidly expanded in undergraduate medical education (UME). However, the assessments used in UME remain variable without national standards. This scoping review characterizes and categorizes current assessment methods using Miller’s pyramid for skills, performance, and competence of POCUS in UME.
A structured protocol was developed using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews (PRISMA-ScR). A literature search of MEDLINE was performed from January 1, 2010, to June 15, 2021. Two independent reviewers screened all titles and abstracts for articles that met inclusion criteria. The authors included all POCUS UME publications in which POCUS-related knowledge, skills, or competence were taught and objectively assessed. Articles were excluded if there were no assessment methods used, if they exclusively used self-assessment of learned skills, were duplicate articles, or were summaries of other literature. Full text analysis and data extraction of included articles were performed by two independent reviewers. A consensus-based approach was used to categorize data and a thematic analysis was performed.

Results
A total of 643 articles were retrieved and 157 articles met inclusion criteria for full review. Most articles (n = 132; 84%) used technical skill assessments including objective structured clinical examinations (n = 27; 17%), and/or other technical skill-based formats including image acquisition (n = 107; 68%). Retention was assessed in n = 98 (62%) studies. One or more levels of Miller’s pyramid were included in 72 (46%) articles. A total of four articles (2.5%) assessed for students’ integration of the skill into medical decision making and daily practice.

Conclusions
Our findings demonstrate a lack of clinical assessment in UME POCUS that focus on integration of skills in daily clinical practice of medical students corresponding to the highest level of Miller’s Pyramid. There exists opportunities to develop and integrate assessment that evaluate higher level competencies of POCUS skills of medical students. A mixture of assessment methods that correspond to multiple levels of Miller’s pyramid should be used to best assess POCUS competence in UME.
Lignin-degrading enzymes from a pathogenic canker-rot fungus Inonotus obliquus strain IO-B2
Authors: Agnestisia Retno , Suzuki Tomohiro , Ono Akiko , Nakamura Luna , Nezu Ikumi , Tanaka Yuki , Aiso Haruna , Ishiguri Futoshi , Yokota Shinso 
Published: June 2023

AbstractInonotus obliquus is a pathogenic fungus found in living trees and has been widely used as a traditional medicine for cancer therapy. Although lignocellulose-degrading enzymes are involved in the early stages of host infection, the parasitic life cycle of this fungus has not been fully understood. In this study, we aimed to investigate the activities of laccase (Lac), manganese peroxidase (MnP), and lignin peroxidase (LiP) from I. obliquus cultivated in Kirk’s medium. The fungus was subjected to genome sequencing, and genes related to wood degradation were identified. The draft genome sequence of this fungus comprised 21,203 predicted protein-coding genes, of which 134 were estimated to be related to wood degradation. Among these, 47 genes associated with lignin degradation were found to have the highest number of mnp genes. Furthermore, we cloned the cDNA encoding a putative MnP, referred to as IoMnP1, and characterized its molecular structure. The results show that IoMnP1 has catalytic properties analogous to MnP. Phylogenetic analysis also confirmed that IoMnP1 was closely related to the MnPs from Pyrrhoderma noxium, Fomitiporia mediterranea, and Sanghuangporus baumii, which belong to the same family of Hymenochaetaceae. From the above results, we suggest that IoMnP1 is a member of MnPs.
The effects of new technology on productivity: technological improvement and reallocation efficiency in the Japanese steelmaking industry
Authors: Kobayashi Ryuki 
Published: June 2023

AbstractThis paper analyzes the effect of new technology for steel refining—the basic oxygen furnace—on productivity growth using the productivity decomposition method. I employ a technique that decomposes productivity growth into four factors: operational improvement, within- and between-technology reallocation, and entry–﻿exit effects. I demonstrate that the following two factors are both substantially important: (i) the rapid operational progress of new technology and (ii) between-technology reallocation both among existing furnaces and through entries. I also find that although the overall allocation efficiency improved, the within-new-technology allocation efficiency declined. The results suggest that government policies encouraged the construction of new furnaces by lowering the cost of introducing new technology, and firms were able to enjoy the high productivity gains from the new technology itself and its rapid growth.