bluuebunny/crossref_metadata_2025_split huggingface dataset:
From ‘no problem’ to ‘a lot of difficulties’: barriers to health service utilization among migrants in Rakai, Uganda
Authors: Young Ruth , Kennedy Caitlin E , Dam Anita , Nakyanjo Neema , Ddaaki William , Kiyingi Anne Catherine , Mukwana Emmanuel , Edwards Abagail , Nalugoda Fred , Chang Larry W , Wawer Maria J , Oaks Maya , Paina Ligia 
Published: April 2023

Abstract
Migration is increasingly common in Africa, especially for employment. Migrants may face additional barriers to accessing health care, including human immunodeficiency virus (HIV) prevention and treatment, compared with long-term residents. Exploring migrants’ experiences with health services can provide insights to inform the design of health programmes. In this study, we used qualitative methods to understand migrants’ barriers to health service utilization in south-central Uganda. This secondary data analysis used data from in-depth semi-structured interviews with 35 migrants and 25 key informants between 2017 and 2021. Interviews were analysed thematically through team debriefings and memos. We constructed three representative migrant journeys to illustrate barriers to accessing health services, reflecting experiences of migrant personas with differing HIV status and wealth. Migrants reported experiencing a range of barriers, which largely depended on the resources they could access, their existing health needs and their ability to form connections and relationships at their destination. Migrants were less familiar with local health services, and sometimes needed more time and resources to access care. Migrants living with HIV faced additional barriers to accessing health services due to anticipated discrimination from community members or health workers and difficulties in continuing antiretroviral therapy when switching health facilities. Despite these barriers, social networks and local connections facilitated access. However, for some migrants, such as those who were poorer or living with HIV, these barriers were more pronounced. Our work highlights how local connections with community members and health workers help migrants access health services. In practice, reducing barriers to health services is likely to benefit both migrants and long-term residents.
Extracting social determinants of health events with transformer-based multitask, multilabel named entity recognition
Authors: Richie Russell , Ruiz Victor M , Han Sifei , Shi Lingyun , Tsui Fuchiang (Rich) 
Published: April 2023

Abstract

Objective
Social determinants of health (SDOH) are nonclinical, socioeconomic conditions that influence patient health and quality of life. Identifying SDOH may help clinicians target interventions. However, SDOH are more frequently available in narrative notes compared to structured electronic health records. The 2022 n2c2 Track 2 competition released clinical notes annotated for SDOH to promote development of NLP systems for extracting SDOH. We developed a system addressing 3 limitations in state-of-the-art SDOH extraction: the inability to identify multiple SDOH events of the same type per sentence, overlapping SDOH attributes within text spans, and SDOH spanning multiple sentences.

Materials and Methods
We developed and evaluated a 2-stage architecture. In stage 1, we trained a BioClinical-BERT-based named entity recognition system to extract SDOH event triggers, that is, text spans indicating substance use, employment, or living status. In stage 2, we trained a multitask, multilabel NER to extract arguments (eg, alcohol “type”) for events extracted in stage 1. Evaluation was performed across 3 subtasks differing by provenance of training and validation data using precision, recall, and F1 scores.

Results
When trained and validated on data from the same site, we achieved 0.87 precision, 0.89 recall, and 0.88 F1. Across all subtasks, we ranked between second and fourth place in the competition and always within 0.02 F1 from first.

Conclusions
Our 2-stage, deep-learning-based NLP system effectively extracted SDOH events from clinical notes. This was achieved with a novel classification framework that leveraged simpler architectures compared to state-of-the-art systems. Improved SDOH extraction may help clinicians improve health outcomes.
Recent trends of characteristics and treatments in adults with newly diagnosed brain metastases
Authors: Koide Yutaro , Nagai Naoya , Miyauchi Risei , Kitagawa Tomoki , Aoyama Takahiro , Shimizu Hidetoshi , Hashimoto Shingo , Tachibana Hiroyuki , Kodaira Takeshi 
Published: April 2023

Abstract

Objective
We aimed to evaluate recent trends in characteristics and treatments among patients with brain metastases in clinical practice.

Methods
All newly diagnosed patients with brain metastases during 2016–2021 at a single cancer center were enrolled. We collected the detailed features of each patient and estimated the number of candidates considered to meet the following criteria used in common clinical trials: Karnofsky performance status ≥ 70 and mutated non-small cell lung cancer, breast cancer or melanoma. The brain metastases treatments were classified as follows: (i) stereotactic radiosurgery, (ii) stereotactic radiosurgery and systemic therapy, (iii) whole-brain radiotherapy, (iv) whole-brain radiotherapy and systemic therapy, (v) surgery, (vi) immune checkpoint inhibitor or targeted therapy, (vii) cytotoxic agents and (ix) palliative care. Overall survival and intracranial progression-free survival were estimated from brain metastases diagnosis to death or intracranial progression.

Results
A total of 800 brain metastases patients were analyzed; 597 (74.6%) underwent radiotherapy, and 422 (52.7%) underwent systemic therapy. In addition, 250 (31.3%) patients were considered candidates for common clinical trials. Compared to 2016, the later years tended to shift from whole-brain radiotherapy to stereotactic radiosurgery (whole-brain radiotherapy: 35.7–29.1% and stereotactic radiosurgery: 33.4–42.8%) and from cytotoxic agents to immune checkpoint inhibitor/targeted therapy (cytotoxic agents: 10.1–5.0 and immune checkpoint inhibitor/targeted therapy: 7.8–10.9%). There was also an increase in the proportion of systemic therapy combined with radiation therapy (from 26.4 to 36.5%). The median overall survival and progression-free survival were 12.7 and 5.3 months, respectively.

Conclusions
This study revealed the diversity of brain metastases patient characteristics, recent changes in treatment selection and the percentage of candidates in clinical trials.
A stress disturbance barrier on a circular torque tube blocking the end effects
Authors: Wang Chung-Hao 
Published: April 2023

AbstractKnowing that the end effects arising from the end torsional loads will disturb the stress distribution in a torque tube, this paper develops a means of blocking the stress disturbances from the end where a torsional load is applied, such that the stress distributions of the Saint-Venant torsion can be maintained. The stress disturbance barrier (SDB) as an end effect shielding barrier is considered installed on an end of a circular toque tube whose material property can be with the cylindrical orthotropy. In general, the SDB is comprised of two layers: the front layer and the blocking layer. The front layer, which is optional and directly contacted with the external load, is for enhancing the durability, while the blocking layer situated between the front layer and the torque tube body is mainly for blocking the stress disturbances. The analysis is based on the state-space formalism, whose uncoupling feature on cylindrically orthotropic materials is beneficial for the further extension of the research. It is found that the parameters crucial to determine an effective SDB with a given thickness are the cylindrical orthotropy parameter and the longitudinal shear modulus. The approach of how to determine the proper material constants for having an effective SDB is clearly provided. As shown by the numerical results presented in the examples, an effective SDB of this research can fully block the stress disturbances from the external torsional loads that can be mathematically expanded by power series.
Copredication and Meaning Transfer
Authors: Liebesman David , Magidor Ofra 
Published: April 2023

Abstract
Copredication occurs when a sentence receives a true reading despite prima facie ascribing categorically incompatible properties to a single entity. For example, ‘The red book is by Tolstoy’ can have a true reading even though it seems that being red is only a property of physical copies, while being by Tolstoy is only a property of informational texts.
A tempting strategy for resolving this tension is to claim that at least one of the predicates has a non-standard interpretation, with the salient proposal involving reinterpretation via meaning transfer. For example, in ‘The red book is by Tolstoy’, one could hold that the predicate ‘by Tolstoy’ is reinterpreted (or on the more specific proposal, transferred) to ascribe a property that physical copies can uncontroversially instantiate, such as expresses an informational text by Tolstoy. On this view, the truth of the copredicational sentence is no longer mysterious. Furthermore, such a reinterpretation view can give a straightforward account of a range of puzzling copredicational sentences involving counting an individuation.
Despite these substantial virtues, we will argue that reinterpretation approaches to copredication are untenable. In §1 we introduce reinterpretation views of copredication and contrast them with key alternatives. In §2 we argue against a general reinterpretation theory of copredication on which every copredicational sentence contains at least one reinterpreted predicate. We also raise additional problems for the more specific proposal of implementing reinterpretation via meaning transfer. In §3 we argue against more limited appeals to reinterpretation on which only some copredicational sentences contain reinterpretation. In §4 we criticize a series of arguments in favour of reinterpretation theories. The upshot is that reinterpretation theories of copredication, and in particular, meaning transfer-based accounts, should be rejected.
Idiopathic Left Ventricular Apical Aneurysm in a Sailor With Moderate Transient Chest Pain: A Unique Perspective on an Atypical Presentation in the Military Population
Authors: Wilinski Michael S , Porter Ian M 
Published: April 2023

ABSTRACT
Left ventricular (LV) apical aneurysm is a rare condition that carries a high risk of fatal cardiac rupture. Wall ruptures are an uncommon catastrophic complication after acute transmural myocardial infarction. Rarely is the rupture only contained by an adherent pericardium or hematoma creating a pseudoaneurysm. This clinical finding calls for emergent surgical intervention. If no ruptures are detectable and myocardium wall integrity is verified, the diagnosis of a true aneurysm can be made to be repaired via elective surgery. The etiological differential for a patient with an LV aneurysm in the setting of normal coronaries and in the absence of prior cardiac surgery remains broad, including traumatic, infectious, and infiltrative causes. In this case report, we demonstrate an atypical and rare presentation of an idiopathic LV apical aneurysm in a physically fit, active duty male in the U.S. Navy.
Electricity, Agency and Class in Lagos Colony,
c
.1860s–1914
Authors: Adebayo Adewumi Damilola 
Published: April 2023

Abstract
European states gradually established colonial rule in Africa between the mid nineteenth century and the beginning of the First World War. Historians have assessed the infrastructure introduced during this period through the lens of colonial state-building and resource extraction. This article offers another perspective by reconstructing the early history of electrification in Lagos Colony, one of the first British colonies in West Africa, within the contexts of African agency (that is, knowledge and socio-political influence) and class. It argues that electricity was not a novelty to Africans when the government opened the first power station in 1898. The principles of electricity were already being taught in the classroom and through public lectures in the 1860s, and temporary exhibitions of electric light had been a feature of Lagos society since the 1880s. Furthermore, because of some demographic advantages, the Africans of nineteenth-century Lagos were able to shape colonial policies, including on financing electricity. Lastly, contrary to colonial African case studies in which scholars have argued that racial politics affected access to electricity, extensive primary sources affirm that a rising number of Africans in Lagos enjoyed electric lighting on the streets, at religious centres and at home from 1898.
Hydraulic tradeoffs underlie enhanced performance of polyploid trees under soil water deficit
Authors: Losada Juan M , Blanco-Moure Nuria , Fonollá Andrés , Martínez-Ferrí Elsa , Hormaza José I 
Published: April 2023

Abstract
The relationships between aerial organ morpho-anatomy of woody polyploid plants with their functional hydraulics under water stress remain largely understudied. We evaluated growth-associated traits, aerial organ xylem anatomy, and physiological parameters of diploid, triploid, and tetraploid genotypes of atemoyas (Annona cherimola × Annona squamosa), which belong to the woody perennial genus Annona (Annonaceae), testing their performance under long-term soil water reduction. The contrasting phenotypes of vigorous triploids and dwarf tetraploids consistently showed stomatal size-density tradeoff. The vessel elements in aerial organs were ∼1.5 times wider in polyploids compared with diploids, and triploids displayed the lowest vessel density. Plant hydraulic conductance was higher in well-irrigated diploids while their tolerance to drought was lower. The phenotypic disparity of atemoya polyploids associated with contrasting leaf and stem xylem porosity traits that coordinate to regulate water balances between the trees and the belowground and aboveground environments. Polyploid trees displayed better performance under soil water scarcity, and consequently, could present more sustainable agricultural and forestry genotypes to cope with water stress.
Examining medical student volunteering during the COVID-19 pandemic as a prosocial behaviour during an emergency
Authors: Byrne Matthew H V , Ashcroft James , Wan Jonathan C M , Alexander Laith , Harvey Anna , Arora Anmol , Schindler Nicholas , Brown Megan E L , Brassett Cecilia 
Published: April 2023

Abstract

Purpose
Understanding the factors that influence prosocial behaviour during the COVID-19 pandemic is essential due to the disruption to healthcare provision.

Methods
We conducted an in-depth, mixed-methods cross-sectional survey, from 2 May 2020 to 15 June 2020, of medical students at medical schools in the United Kingdom. Data analysis was informed by Latané and Darley’s theory of prosocial behaviour during an emergency.

Results
A total of 1145 medical students from 36 medical schools responded. Although 947 (82.7%) of students were willing to volunteer, only 391 (34.3%) had volunteered. Of the students, 92.7% understood they may be asked to volunteer; however, we found deciding one’s responsibility to volunteer was mitigated by a complex interaction between the interests of others and self-interest. Further, concerns revolving around professional role boundaries influenced students’ decisions over whether they had the required skills and knowledge.

Conclusion
We propose two additional domains to Latané and Darley’s theory that medical students consider before making their final decision to volunteer: ‘logistics’ and ‘safety’. We highlight modifiable barriers to prosocial behaviour and provide suggestions regarding how the conceptual framework can be operationalized within educational strategies to address these barriers. Optimizing the process of volunteering can aid healthcare provision and may facilitate a safer volunteering process.
Key messages
What is already known on this topic:
There is a discrepancy between the number of students willing to volunteer during pandemics and disasters, and those who actually volunteer. Understanding the factors that influence prosocial behaviour during the current COVID-19 pandemic and future pandemics and disasters is essential.
What this study adds:
We expanded on Latané and Darley’s theory of prosocial behaviour in an emergency and used this to conceptualize students’ motivations to volunteer, highlighting a number of modifiable barriers to prosocial behaviour during the COVID-19 pandemic.
How this study might affect research, practice, or policy:
We provide suggestions regarding how the conceptual framework can be operationalized to support prosocial behaviours during emergencies for the ongoing COVID-19 pandemic and future crises.
NOTCH signaling inhibition after DAPT treatment exacerbates alveolar echinococcosis hepatic fibrosis by blocking M1 and enhancing M2 polarization
Authors: Li Bin , Wang Liang , Qi Xinwei , Liu Yumei , Li Jiajun , Lv Jie , Zhou Xuan , Cai Xuanlin , Shan Jiaoyu , Ma Xiumin 
Published: April 2023

AbstractAlveolar echinococcosis (AE) is a lethal helminthic liver disease caused by persistent infection with Echinococcus multilocularis (E. multilocularis). Although more and more attention has been paid to the macrophages in E. multilocularis infection, the mechanism of macrophage polarization, a critical player in liver immunity, is seldom studied. NOTCH signaling is involved in cell survival and macrophage‐mediated inflammation, but the role of NOTCH signaling in AE has been equally elusive. In this study, liver tissue samples from AE patients were collected and an E. multilocularis infected mouse model with or without blocking NOTCH signaling was established to analyze the NOTCH signaling, fibrotic and inflammatory response of the liver after E. multilocularis infection. Changes in polarization and origin of hepatic macrophages were analyzed by flow cytometry. In vitro qRT‐PCR and Western blot assays were performed to analyze key receptors and ligands in NOTCH signaling. Our data demonstrated that hepatic fibrosis develops after AE, and the overall blockade of NOTCH signaling caused by DAPT treatment exacerbates the levels of hepatic fibrosis and alters the polarization and origin of hepatic macrophages. Blocking NOTCH signaling in macrophages after E. multilocularis infection downregulates M1 and upregulates M2 expression. The downregulation of NTCH3 and DLL‐3 in the NOTCH signaling pathway is significant. Therefore, NOTCH3/DLL3 may be the key pathway in NOTCH signaling regulating macrophage polarization affecting fibrosis caused by AE.
Regulation of VEGFR2 and AKT signaling by Musashi-2 in lung cancer
Authors: Bychkov Igor , Topchu Iuliia , Makhov Petr , Kudinov Alexander , Patel Jyoti D. , Boumber Yanis 
Published: April 2023

AbstractLung cancer is the most frequently diagnosed cancer type and the leading cause of cancer-related deaths worldwide. Non-small cell lung cancer (NSCLC) represents most of the lung cancer. Vascular endothelial growth factor receptor-2 (VEGFR2) is a member of the VEGF family of receptor tyrosine kinase proteins, expressed on both endothelial and tumor cells which is one of the key proteins contributing to cancer development and involved in drug resistance. We previously showed that Musashi-2 (MSI2) RNA-binding protein is associated with NSCLC progression by regulating several signaling pathways relevant to NSCLC. In this study, we performed Reverse Protein Phase Array (RPPA) analysis of murine lung cancer which nominated VEGFR2 protein as strongly positively regulated by MSI2. Next, we validated VEGFR2 protein regulation by MSI2 in several human NSCLC cell line models. Additionally, we found that MSI2 affected AKT signaling via negativePTENmRNA translation regulation. In silico prediction analysis suggested that both VEGFR2 and PTEN mRNAs have predicted binding sites for MSI2. We next performed RNA immunoprecipitation coupled with quantitative PCR which confirmed that MSI2 directly binds to VEGFR2 and PTEN mRNAs, suggesting direct regulation mechanism. Finally, MSI2 expression positively correlated with VEGFR2 and VEGF-A protein levels in human NSCLC samples. We conclude that MSI2/VEGFR2 axis contributes to NSCLC progression and is worth further investigations and therapeutic targeting.
Hyperconnectivity of two separate long-range cholinergic systems contributes to the reorganization of the brain functional connectivity during nicotine withdrawal in male mice
Authors: Carrette Lieselot L.G. , Kimbrough Adam , Davoudian Pasha A. , Kwan Alex C. , Collazo Andres , George Olivier 
Published: April 2023

AbstractChronic nicotine results in dependence with withdrawal symptoms upon discontinuation of use, through desensitization of nicotinic acetylcholine receptors and altered cholinergic neurotransmission. Nicotine withdrawal is associated with increased whole-brain functional connectivity and decreased network modularity, however, the role of cholinergic neurons in those changes is unknown. To identify the contribution of nicotinic receptors and cholinergic regions to changes in the functional network, we analyzed the contribution of the main cholinergic regions to brain-wide activation of the immediate early-gene FOS during withdrawal in male mice and correlated these changes with the expression of nicotinic receptor mRNA throughout the brain. We show that the main functional connectivity modules included the main long-range cholinergic regions, which were highly synchronized with the rest of the brain. However, despite this hyperconnectivity they were organized into two anticorrelated networks that were separated into basal forebrain projecting and brainstem-thalamic projecting cholinergic regions, validating a long-standing hypothesis of the organization of the brain cholinergic systems. Moreover, baseline (without nicotine) expression ofChrna2,Chrna3,Chrna10, andChrndmRNA of each brain region correlated with withdrawal-induced changes in FOS expression. Finally, by mining the Allen Brain mRNA expression database, we were able to identify 1755 gene candidates and three pathways (Sox2-Oct4-Nanog, JAK-STAT, and MeCP2-GABA) that may contribute to nicotine withdrawal-induced FOS expression. These results identify the dual contribution of the basal forebrain and brainstem-thalamic cholinergic systems to whole-brain functional connectivity during withdrawal; and identify nicotinic receptors and novel cellular pathways that may be critical for the transition to nicotine dependence.Significance StatementDiscontinuation of nicotine use in dependent users is associated with increased whole-brain activation and functional connectivity and leads to withdrawal symptoms. Here we investigated the contribution of the nicotinic cholinergic receptors and main cholinergic projecting brain areas in the whole-brain changes associated with withdrawal. This not only allowed us to visualize and confirm the previously described duality of the cholinergic brain system using this novel methodology, but also identify nicotinic receptors together with 1751 other genes that contribute, and could thus be targets for treatments against, nicotine withdrawal and dependence.