bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association Between Educational Attainment and Thyroid Function: Results From Mendelian Randomization and the NHANES Study
Authors: Yuan Jie , Liu Xue , Wang Xinhui , Zhou Huizhi , Wang Yuyao , Tian Guoyu , Liu Xueying , Tang Mulin , Meng Xue , Kou Chunjia , Yang Qingqing , Li Juyi , Zhang Li , Yuan Zhongshang , Zhang Haiqing 
Published: June 2023

Abstract

Context
Many observational studies have reported on the association between educational attainment (EA) and thyroid function, but the causal relationship remains unclear.

Objective
We aimed to obtain causal effects of EA on thyroid function and to quantify the mediating effects of modifiable risk factors.

Methods
Two-sample mendelian randomization (MR) was performed by using summary statistics from large genome-wide association studies (GWAS) to assess the effect of EA on thyroid function, including hypothyroidism, hyperthyroidism, thyrotropin (TSH), and free thyroxine (FT4). A multivariable analysis was conducted to assess the mediating role of smoking and help to explain the association between EA and thyroid function. Similar analysis was further performed using data from the National Health and Nutrition Examination Survey (NHANES) 1999 to 2002.

Results
In MR analysis, EA was causally associated with TSH (β = .046; 95% CI, 0.015-0.077; P = 4.00 × 10−3), rather than hypothyroidism, hyperthyroidism, and FT4. Importantly, smoking could serve as a mediator in the association between EA and TSH, in which the mediating proportion was estimated to be 10.38%. After adjusting for smoking in the multivariable MR analysis, the β value of EA on TSH was attenuated to 0.030 (95% CI, 0.016-0.045; P = 9.32 × 10−3). Multivariable logistic regression model in NHANES suggested a dose-response relationship between TSH (quartile [Q]4 vs Q1: odds ratio = 1.33; 95% CI, 1.05-1.68; P for trend = .023) and EA. Smoking, systolic blood pressure, and body mass index partially mediated the association between EA and TSH, with the proportion of the mediation effects being 43.82%, 12.28%, and 6.81%, respectively.

Conclusion
There is a potentially causal association between EA and TSH, which could be mediated by several risk factors, such as smoking.
Horizontal Advantage: Choice of Postsecondary Field of Study Among Children of Immigrants
Authors: Borgen Solveig Topstad , Hermansen Are Skeie 
Published: June 2023

Abstract
Educational expansion has raised the influence of sorting across postsecondary educational fields on children's future life chances. Yet, little is known about horizontal ethnic stratification in the choice of field of study among children of immigrant parents, whose parents often have moderate absolute levels of education relative to native-born parents but tend to be positively selected on education relative to nonmigrants in the origin country. Using rich administrative data from Norway, we study the educational careers of immigrant descendants relative to the careers of children of native-born parents. Our results show that children of immigrants from non-European countries have a higher likelihood of entering higher education and enrolling in high-paying fields of study compared with children of natives, despite having poorer school grades and disadvantaged family backgrounds. However, immigrant parents' positive selectivity provides limited insight into why children of immigrants exhibit high ambitions later in their postsecondary educational careers. These findings document a persistent pattern of horizontal ethnic advantage in postsecondary education in which ambitious children of immigrants are more likely to enter into more prestigious and economically rewarding fields of study than their fellow students with native-born parents.
Lock Them Up: The Cold Conservatism of Ang Lee's The Ice Storm
Authors: Flanery Patrick 
Published: June 2023

Abstract
This article considers how The Ice Storm (dir. Ang Lee, US, 1997) reframes the politics of Rick Moody's novel of the same name and works via a network of symbols to align character Elena Hood (Joan Allen) with Hillary Clinton, suggesting an analogy between the scandals of the Richard Nixon and Bill Clinton presidencies. Simultaneously, the film mounts a sustained campaign to constrain female sexuality, chiefly through its sanitizing of male characters’ own sexuality and recasting of Wendy Hood (Christina Ricci) as a sexually predatory Riding Hood/witch figure. Through its constraining of social transgression more generally, punishing Mikey Carver (Elijah Wood) for the sins of his parents and wider community in a way that can be read fruitfully through Jacques Derrida's “Plato's Pharmacy,” the film produces a narrative of profound conservatism even as it courts progressive audiences. Notwithstanding its “independent” status, its distribution through Fox (then owned by Rupert Murdoch's News Corp), situates the film institutionally in ways that challenge our understanding of the category of “independent” as necessarily politically progressive. The film's double-dealing, this article argues, demands that we attend to the phenomenon of a film that invites identification with progressive or transgressive characters only to punish them with reintegration into regimes of the normal or, failing such a maneuver, death. The lingering question this article identifies is how we hold to account films that are misunderstood as belonging to canons of progressive aesthetics while functioning as stealth engines of retrograde normativity.
Archiving Feeling in Yvonne Rainer's Journeys from Berlin/1971
Authors: Shaskevich Helena 
Published: June 2023

Abstract
Yvonne Rainer's third and most explicitly political feature-length film, Journeys from Berlin/1971 (US/UK/West Germany, 1979) explores the relationship between personal and political trauma through the lens of the instability and violence that ravaged West Germany during the period commonly referred to as the German Autumn (1977). Through a close reading of the film's formal structure, this essay argues that Journeys from Berlin/1971 represents Rainer's attempt to imagine a feminist counterpublic in the form of a queer “archive of feelings.” This essay traces the film's narrative junctures, comprised of five distinct and incongruous tracks layered and juxtaposed in a collage-like form, arguing that Rainer creates points of connection between scenes of domestic intimacy and political violence. In doing so, Journeys bridges the typically privatized and historically negated realm of everyday traumas of women and queer subjects with the public space of political trauma and asserts the primacy of both within national histories. This essay further argues that the female revolutionaries who emerge within these charged touchpoints act as figures of queer possibility. Their explicit and often spectacular refusals and failures — of the liberatory promises of bourgeois motherhood on the one hand, and political activism on the other — deny any possibility of a reparative fantasy within the film. Made during a period of significant aesthetic and personal change in Rainer's life following her attempted suicide, the film's form as an alternative archive of feminist resistance ultimately acts as both catharsis and a means of bringing this alternative community into being.
Long-Term Outcomes of Stereotactic Radiosurgery for Postoperative World Health Organization Grade I Skull Base Meningioma: Utility of Ki-67 Labeling Index as a Prognostic Indicator
Authors: Shinya Yuki , Hasegawa Hirotaka , Shin Masahiro , Kawashima Mariko , Umekawa Motoyuki , Katano Atsuto , Ikemura Masako , Ushiku Tetsuo , Ohara Kenta , Okano Atsushi , Teranishi Yu , Miyawaki Satoru , Saito Nobuhito 
Published: June 2023

BACKGROUND:
Gross total resection, without causing neurological deficits, is challenging in skull base meningioma (SBM). Therefore, stereotactic radiosurgery (SRS) is an important approach for SBMs; however, it is difficult to predict the long-term prognosis.

OBJECTIVE:
To identify the predictive factors for tumor progression after SRS for World Health Organization (WHO) grade I SBMs, focusing on the Ki-67 labeling index (LI).

METHODS:
In this single-center retrospective study, factors affecting progression-free survival rates (PFSs) and neurological outcomes in patients undergoing SRS for postoperative SBMs were evaluated. Based on the Ki-67 LI, patients were classified into 3 groups: low (<4%), intermediate (4%-6%), and high LI (>6%).

RESULTS:
In the 112 patients enrolled, the cumulative 5- and 10-year PFSs were 93% and 83%, respectively. The PFSs were significantly higher in the low LI group (95% at 10 years) compared with the other groups (intermediate LI, 60% at 10 years, P = .007; high LI, 20% at 10 years, P = .001). Multivariable Cox proportional hazard analysis demonstrated that the Ki-67 LI was significantly associated with the PFSs (low vs intermediate LI; hazard ratio, 6.00; 95% CI, 1.41-25.54; P = .015; low vs high LI; hazard ratio, 31.90; 95% CI, 5.59-181.77; P = .001).

CONCLUSION:
Ki-67 LI may be a useful predictor of long-term prognosis in SRS for postoperative WHO grade I SBM. SRS provides excellent long- and mid-term PFSs in SBMs with Ki-67 LIs <4% or 4% to 6%, with a low risk of radiation-induced adverse events.
A monoclonal antibody raised against human EZH2 cross-reacts with the RNA-binding protein SAFB
Authors: Cherney Rachel E. , Mills Christine A. , Herring Laura E. , Braceros Aki K. , Calabrese J. Mauro 
Published: June 2023

ABSTRACT
The Polycomb Repressive Complex 2 (PRC2) is a conserved enzyme that tri-methylates Lysine 27 on Histone 3 (H3K27me3) to promote gene silencing. PRC2 is remarkably responsive to the expression of certain long noncoding RNAs (lncRNAs). In the most notable example, PRC2 is recruited to the X-chromosome shortly after expression of the lncRNA Xist begins during X-chromosome inactivation. However, the mechanisms by which lncRNAs recruit PRC2 to chromatin are not yet clear. We report that a broadly used rabbit monoclonal antibody raised against human EZH2, a catalytic subunit of PRC2, cross-reacts with an RNA-binding protein called Scaffold Attachment Factor B (SAFB) in mouse embryonic stem cells (ESCs) under buffer conditions that are commonly used for chromatin immunoprecipitation (ChIP). Knockout of EZH2 in ESCs demonstrated that the antibody is specific for EZH2 by western blot (no cross-reactivity). Likewise, comparison to previously published datasets confirmed that the antibody recovers PRC2-bound sites by ChIP-Seq. However, RNA-IP from formaldehyde-crosslinked ESCs using ChIP wash conditions recovers distinct peaks of RNA association that co-localize with peaks of SAFB and whose enrichment disappears upon knockout of SAFB but not EZH2. IP and mass spectrometry-based proteomics in wild-type and EZH2 knockout ESCs confirm that the EZH2 antibody recovers SAFB in an EZH2-independent manner. Our data highlight the importance of orthogonal assays when studying interactions between chromatin-modifying enzymes and RNA.
SCG10 is required for peripheral axon maintenance and regeneration in mice
Authors: Li Yuanjun , Tian Yonglu , Pei Xiayuhe , Zheng Pengli , Miao Linqing , Li Lingjun , Luo Chunxiong , Zhang Peixun , Jiang Baoguo , Teng Junlin , Huang Ning , Chen Jianguo 
Published: June 2023

ABSTRACT
Proper microtubule dynamics are critical for neuronal morphogenesis and functions, and their dysregulation results in neurological disorders and regeneration failure. Superior cervical ganglion-10 (SCG10, also known as stathmin-2 or STMN2) is a well-known regulator of microtubule dynamics in neurons, but its functions in the peripheral nervous system remain largely unknown. Here, we show that Scg10 knockout mice exhibit severely progressive motor and sensory dysfunctions with significant sciatic nerve myelination deficits and neuromuscular degeneration. Additionally, increased microtubule stability, shown by a significant increase in tubulin acetylation and decrease in tubulin tyrosination, and decreased axonal transport were observed in Scg10 knockout dorsal root ganglion (DRG) neurons. Furthermore, SCG10 depletion impaired axon regeneration in both injured mouse sciatic nerve and cultured DRG neurons following replating, and the impaired axon regeneration was found to be induced by a lack of SCG10-mediated microtubule dynamics in the neurons. Thus, our results highlight the importance of SCG10 in peripheral axon maintenance and regeneration.
Prevalence and determinants of obesity among individuals with diabetes in Indonesia
Authors: Azam Mahalul , Sakinah Luluk Fadhoh , Kartasurya Martha Irene , Fibriana Arulita Ika , Minuljo Tania Tedjo , Aljunid Syed Mohamed 
Published: June 2023

Background: Obesity and diabetes mellitus (DM), both individually or simultaneously, increase the risk of morbidity and mortality. The present study aimed to determine the prevalence and determinants of obesity among diabetic individuals in Indonesia. Methods: Data were extracted based on 2018 Indonesian Basic Health Survey (Riset Kesehatan Dasar=RISKESDAS). This study involved all individuals with DM and categorized obesity based on body mass index. After data clearing, this study analyzed 3911 DM subjects of the 33,905 subjects acquired from the 2018 RISKESDAS. The study also observed demographic data, diabetes control parameters, history of hypertension, lipid profiles, and food consumption patterns. These variables were involved in a Chi-square test, and related variables were then involved in the Binary logistic regression to define the independent determinants of obesity among DM subjects. Results: Of the 3911DM subjects included, the study found an obesity prevalence of 32.9%. This study found that female (prevalence odds ratio [POR]=2.15; 95% CI: 1.76-2.62), age 15-44 years (POR=2.46; 95% CI: 1.83-3.33), urban residence (POR=1.49; 95% CI: 1.25-1.77), history of hypertension (POR=1.25; 95% CI: 1.04-1.51), high diastolic blood pressure (POR=1.90; 95% CI: 1.58-2.29), high LDL (POR=1.44; 95% CI: 1.13-1.84), and high triglycerides (POR=1.27; 95% CI: 1.07-1.50) were the risk factor of obesity among DM subjects; while high HDL (POR=0.60; 95% CI: 0.46-0.78 higher education (POR=0.64; 95% CI: 0.53-0.78) and unmarried (POR=0.73; 95% CI: 0.59-0.90) were protective factors of obesity among DM subjects. Conclusions:. The study concluded that almost one-third of DM subjects in Indonesia were obese. Female, age, urban residence, education level, history of hypertension, diastolic blood pressure, and lipid profiles were all associated with obesity among DM subjects in Indonesia. These findings suggest that monitoring and controlling of related determinants is needed to prevent complications caused by the doubled burden of diabetes and obesity.
Crowd-Judging on Two-Sided Platforms: An Analysis of In-Group Bias
Authors: Kwan Alan P. , Yang S. Alex , Zhang Angela Huyue 
Published: June 2023

Disputes over transactions on two-sided platforms are common and usually arbitrated through platforms’ customer service departments or third-party service providers. This paper studies crowd-judging, a novel crowdsourcing mechanism whereby users (buyers and sellers) volunteer as jurors to decide disputes arising from the platform. Using a rich data set from the dispute resolution center at Taobao, a leading Chinese e-commerce platform, we aim to understand this innovation and propose and analyze potential operational improvements with a focus on in-group bias (buyer jurors favor the buyer, likewise for sellers). Platform users, especially sellers, share the perception that in-group bias is prevalent and systematically sways case outcomes as the majority of users on such platforms are buyers, undermining the legitimacy of crowd-judging. Our empirical findings suggest that such concern is not completely unfounded: on average, a seller juror is approximately 10% likelier (than a buyer juror) to vote for a seller. Such bias is aggravated among cases that are decided by a thin margin and when jurors perceive that their in-group’s interests are threatened. However, the bias diminishes as jurors gain experience: a user’s bias reduces by nearly 95% as experience grows from zero to the sample median level. Incorporating these findings and juror participation dynamics in a simulation study, the paper delivers three managerial insights. First, under the existing voting policy, in-group bias influences the outcomes of no more than 2% of cases. Second, simply increasing crowd size through either a larger case panel or aggressively recruiting new jurors may not be efficient in reducing the adverse effect of in-group bias. Finally, policies that allocate cases dynamically could simultaneously mitigate the impact of in-group bias and nurture a more sustainable juror pool. This paper was accepted by Vishal Gaur, operations management. Funding: S. A. Yang and A. Zhang acknowledge the support of the Hong Kong General Research Fund [Grant “Decentralizing Platform Governance: Innovations from China; Project 17614921]. Supplemental Material: The online appendix and data are available at https://doi.org/10.1287/mnsc.2023.4818 .
An analysis of Chinese nursing electronic medical records to predict violence in psychiatric inpatients using text mining and machine learning techniques
Authors: Hu Ya-Han , Hung Jeng-Hsiu , Hu Li-Yu , Huang Sheng-Yun , Shen Cheng-Che 
Published: June 2023

Background
The prevalence of violence in acute psychiatric wards is a critical concern. According to a meta-analysis investigating violence in psychiatric inpatient units, researchers estimated that approximately 17% of inpatients commit one or more acts of violence during their stay. Inpatient violence negatively affects health-care providers and patients and may contribute to high staff turnover. Therefore, predicting which psychiatric inpatients will commit violence is of considerable clinical significance.

Objective
The present study aimed to estimate the violence rate for psychiatric inpatients and establish a predictive model for violence in psychiatric inpatients.

Methods
We collected the structured and unstructured data from Chinese nursing electronic medical records (EMRs) for the violence prediction. The data was obtained from the psychiatry department of a regional hospital in southern Taiwan, covering the period between January 2008 and December 2018. Several text mining and machine learning techniques were employed to analyze the data.

Results
The results demonstrated that the rate of violence in psychiatric inpatients is 19.7%. The patients with violence in psychiatric wards were generally younger, had a more violent history, and were more likely to be unmarried. Furthermore, our study supported the feasibility of predicting aggressive incidents in psychiatric wards by using nursing EMRs and the proposed method can be incorporated into routine clinical practice to enable early prediction of inpatient violence.

Conclusions
Our findings may provide clinicians with a new basis for judgment of the risk of violence in psychiatric wards.
Enteral nutrition management in critically ill adult patients and its relationship with intensive care unit-acquired muscle weakness: A national cohort study
Authors: Zaragoza-García Ignacio , Arias-Rivera Susana , Frade-Mera María Jesús , Martí Joan Daniel , Gallart Elisabet , San José-Arribas Alicia , Velasco-Sanz Tamara Raquel , Blazquez-Martínez Eva , Raurell-Torredà Marta 
Published: June 2023

Objective
To assess the incidence and determinants of ICU-acquired muscle weakness (ICUAW) in adult patients with enteral nutrition (EN) during the first 7 days in the ICU and mechanical ventilation for at least 48 hours.

Methods
A prospective, nationwide, multicentre cohort study in a national ICU network of 80 ICUs. ICU patients receiving invasive mechanical ventilation for at least 48 hours and EN the first 7 days of their ICU stay were included. The primary outcome was incidence of ICUAW. The secondary outcome was analysed, during days 3–7 of ICU stay, the relationship between demographic and clinical data to contribute to the onset of ICUAW, identify whether energy and protein intake can contribute independently to the onset of ICUAW and degree of compliance guidelines for EN.

Results
319 patients were studied from 69 ICUs in our country. The incidence of ICUAW was 153/222 (68.9%; 95% CI [62.5%-74.7%]). Patients without ICUAW showed higher levels of active mobility (p = 0.018). The logistic regression analysis showed no effect on energy or protein intake on the onset of ICUAW. Overfeeding was observed on a significant proportion of patient-days, while more overfeeding (as per US guidelines) was found among patients with obesity than those without (42.9% vs 12.5%; p<0.001). Protein intake was deficient (as per US/European guidelines) during ICU days 3–7.

Conclusions
The incidence of ICUAW was high in this patient cohort. Early mobility was associated with a lower incidence of ICUAW. Significant overfeeding and deficient protein intake were observed. However, energy and protein intake alone were insufficient to explain ICUAW onset.

Relevance to clinical practice
Low mobility, high incidence of ICUAW and low protein intake suggest the need to train, update and involve ICU professionals in nutritional care and the need for early mobilization of ICU patients.
Relationships between the COVID-19 lockdown, socioeconomic factors and acute coronary syndrome hospitalisations in France
Authors: Plat Rodney , Vasile Maria , Roubille François , Mercier Grégoire 
Published: June 2023

Introduction
Worldwide, the COVID-19 pandemic has been associated with an overall drop in acute coronary syndrome (ACS) hospitalizations. Additionally, there is a well-known association between ACS and socioeconomic status. This study aims to assess the COVID-19 effect on ACS admissions in France during the first national lockdown and investigate the factors associated with its spatial heterogeneity.

Materials and methods
In this retrospective study, we used the French hospital discharge database (PMSI) to estimate ACS admission rates in all public and private hospitals in 2019 and 2020. A negative binomial regression explored the nationwide change in ACS admissions during lockdown compared with 2019. A multivariate analysis explored the factors associated with the ACS admission incidence rate ratio (IRR, 2020 incidence rate/2019 incidence rate) variation at the county level.

Results
We found a significant but geographically heterogeneous nationwide reduction in ACS admissions during lockdown (IRR 0·70 [0·64–0·76]). After adjustment for cumulative COVID-19 admissions and the ageing index, a higher share of people on short-term working arrangements during lockdown at the county level was associated with a lower IRR, while a higher share of individuals with a high school degree and a higher density of acute care beds were associated with a higher ratio.

Conclusions
During the first national lockdown, there was an overall decrease in ACS admissions. Local provision of inpatient care and socioeconomic determinants linked to occupation were independently associated with the variation in hospitalizations.