bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimal decisions and coordination mechanism in a green supply chain with loss‐averse consumers in environmental quality
Authors: Li Bing , Zong Shengliang , Zhang Longbing 
Published: August 2023

AbstractWe consider consumers' loss aversion in environmental quality and develop a two‐period game theoretical model to investigate the optimal pricing and environmental quality decisions for a green supply chain where a manufacturer sells products to consumers through a retailer. We then introduce a two‐part tariff contract to coordinate the supply chain for both periods. We suggest that optimal decisions in the second period depend on the reference point of the first period in the decentralized supply chain. A higher reference point leads to the increased environmental quality of products, prices, and profits of supply chain members in the second period. However, when the reference point is sufficiently high, the environmental quality will be lower to avoid excessive environmental investment costs. Furthermore, consumers' loss aversion reduces the environmental quality of products when the reference point is low. As consumers' loss aversion increases, the manufacturer's profit rises, while the wholesale and retail prices and the retailer's profit show a decreasing and then increasing trend. Finally, we find that a two‐part tariff contract enables the two‐period supply chain to be coordinated and achieve Pareto improvements in profit and environmental quality. This study sheds valuable light on understanding consumer environmental preferences and irrational behavior for supply chain decision‐making and green product design.
Perceptions of nurses working in mental health services regarding the recovery‐oriented care approach: Findings from Africa
Authors: Kealeboga K. M. , Manyedi E. M. , Moloko‐Phiri S. 
Published: August 2023

AbstractBackgroundThe recovery‐oriented care approach in mental health is recognised as the vision for mental health. People with a diagnosis of mental illness value the support and the individualistic approach emphasised in the recovery‐oriented mental health care approach as they believe it facilitates their recovery. However, as a developing country, Botswana has a long way to go in availing mental health care resources to people with mental illness, let alone adopting new mental health approaches such as recovery.AimThe study aimed to explore the perceptions of nurses working in mental health care facilities of recovery‐oriented mental health care.MethodsFour mental health facilities from Botswana consented to participate in the study. A descriptive qualitative approach was utilised to explore nurses' views on how they perceive recovery from mental illness. Thirty nurses participated in the focus group discussions across the four study sites. All participants consented to participate and to be recorded. Tesch's (in Qualitative enquiry and research design: Choosing among five approaches. 3th ed. SAGE, 2013:198) thematic analysis was used for this study.ResultsThree main themes were identified in participants' perceptions of recovery‐oriented care mental health: Recovery from mental illness is possible, the Meaning of recovery from mental illness and Factors facilitating recovery from mental illness.Public ContributionThe study offers a perspective into how nurses perceive recovery‐oriented approaches from a developing country and add to the gap existing in recovery‐oriented mental health care approach from the African context.
Hydrogeological structure of a granitic mountain catchment inferred from multi‐method electrical resistivity datasets
Authors: Lajaunie Myriam , Gance Julien , Sailhac Pascal , Malet Jean‐Philippe , Warden Sheldon , Larnier Hugo 
Published: August 2023

AbstractAltered crystalline catchments are complex to study and model, as they present multi‐scale properties that control their hydrogeological behaviour and that are difficult to capture through a single geophysical imaging technique. Several volumes of interest must be sampled in order that both small‐scale (porosity, layering) and large‐scale (bedrock, weathering, faults) heterogeneities can be captured. We propose a geoelectrical model of the Strengbach catchment (Vosges Mountains, France), aiming at identifying the weathered structures and hydrogeological functioning of the aquifer. This is achieved through electrical resistivity tomography (ERT) and Controlled‐Source Audio‐Magnetotelluric (CSAMT) measurements and the use of appropriate measurement set‐ups. Meters‐scale shallow contrasts in the top soil, catchment‐scale shallow contrasts (top 30 m), and large‐scale vertical contrasts (up to 150 m) were resolved through this methodology. A structural interpretation is proposed, based on information provided by borehole measurements (gamma ray, optical images), analysis of sampled waters, and geological mapping. The limits at depth of the weathered and fractured granite, not detected by ERT, are detected by CSAMT. The analysis showed that the weathering state of the granite controls, at first order, the electrical resistivity signal. Shallow geoelectrical signal (first 30 m) is particularly driven by surface conductivity and hence by the clay content, whereas deep geoelectrical signal may arise from both the ionic content of pore waters and the clay content. A structural model is proposed and discussed. Geoelectrical contrasts revealed several qualities of weathered saprolite between the northern and the southern slopes. The inferred structural model and the distribution of weathered and unweathered crystalline units are considered for their respective effect on the hydrogeology, leading to the proposition of a new hydrogeological conceptual model of the catchment.
Design of 3D graphene‐Ni microsphere based polymeric composites for highly efficient and absorption‐dominated electromagnetic interference shielding performance
Authors: Qiu Lijuan , Ran Linxin , Sun Furong , Chen Zhiyi , Yi Longfei , Zhao Lijuan , Ji Xiaoying 
Published: August 2023

AbstractThe development of polymeric composites that possess both exceptional electromagnetic interference shielding effectiveness (EMI SE) and high absorption capacity has always been appealing, yet it continues to pose a significant challenge. To this end, we disclose a hollow and spherical shielding unit that could achieve “absorption‐reflection‐attenuation” process for incident electromagnetic (EM) wave, which was fabricated through decorating Ni nanoparticles onto rGO hollow microspheres by virtue of Pickering emulsification method followed by thermal annealing. With integrated magnetic and electric parts, the consequent shielding composite by assembling these microspheres into PDMS displayed not only a favorable EMI SE of 44 dB across the entire x‐band, but also significantly improved absorption performance that has exceeded 95% of the total SE. Moreover, the power coefficient of absorption (A) is up to 0.73 at the pyrolysis temperature of 550°C. Such admirable performance is mainly attributed to the synergistic effect of conductive rGO walls, magnetic Ni nanoparticles, as well as the unique spherical architecture, which has enabled more efficient capture and attenuation of EM waves. Herein, this research has highlighted the development of polymeric composites for high‐performance EMI shielding applications.Highlights
Reflection‐absorption‐integrated shielding compartment was designed.
Decorating magnetic Ni nanoparticles onto rGO hollow microspheres.
High EMI SE with enhanced absorption ability was acquired.
Unique structure generating synergistic effect on EMI shielding
A comparative analysis of agronomic water‐use efficiency and its proxy measures as derived from key morpho‐physiological and supportive quantitative genetics attributes of perennial ryegrass under imposed drought
Authors: Weerarathne L. V. Y. , Jahufer Z. , Schäufele R. , Lopez I. , Matthew C. 
Published: August 2023

AbstractWater‐use efficiency (WUE) is an under‐researched but very important drought tolerance trait in forage breeding. This research estimated quantitative genetic parameters of morpho‐physiological traits linked to agronomic water‐use efficiency (WUEA) and its proxy measures based on δ13C (WUEi) or gas exchange (evapotranspiration, WUEAET, or stomatal conductance WUEASC) of genotypes from half‐sib families of Lolium perenne L. (PRG) in a simulated summer drought cycle. Principal component analysis (PCA) of trait data distinguished a group of PRG genotypes where high WUEA and dry matter yield was associated with deep rooting, leaf hydration at more negative leaf osmotic and water potential, and reduced soil moisture depletion. Plants with this trait association sustained net assimilation and postdefoliation regrowth in drought. However, WUEi, WUEASC, and WUEAET were poorly correlated with most traits of interest at p < .05. Another PCA revealed a weak association between WUEA and its proxy measures under conditions tested. Quantitative genetic parameters including high estimates of narrow‐sense heritability () of WUEA and related traits emphasized the genetic potential of the key trait combination for selecting PRG for improved drought tolerance. Research findings highlight the relative importance of WUEA and its proxy measures in the broad definition of PRG drought tolerance for breeding purposes.
A compositional view comparing modern biological condensates and primitive phase‐separated compartments
Authors: Cannelli Selene M. C. , Gupta Ritvik , Nguyen Tan , Poddar Arunava , Sharma Srishti , Vithole Prachiti V. , Jia Tony Z. 
Published: August 2023

AbstractLiquid–liquid phase separation (LLPS) is a process that often occurs due to binding between oppositely charged biopolymers, and has gained increasing attention recently due to their ubiquity in biological systems and ability to direct essential cellular processes. However, while these discoveries in biology are recent, the field of origins of life has been investigating LLPS for nearly 100 years, ever since the first suggestions by Oparin and Haldane that primitive LLPS could have been precursors to the first cells on Earth. Since then, a significant amount of work has been done to elucidate different primitive LLPS systems that could have been relevant as protocellular models. Given the structural similarities between primitive LLPS and modern membraneless organelles, there may even be an evolutionary link between the two, although this remains a question to be answered. Nevertheless, in order to answer this, a source that compares compositional aspects of modern biological condensates and primitive LLPS is necessary. Here, we first focus on membraneless organelles composed of intrinsically disordered proteins (IDPs) and nucleic acids. Then, as a parallel, we explore primitive membraneless compartments composed of simple biopolymers such as short peptides and nucleic acids. This is followed by a discussion of how the first biomolecules on Earth may have originated, analyzing the environmental and chemical conditions that could have favored primitive LLPS processes. Finally, we directly compare composition of modern biological condensates and primitive phase‐separated compartments, further discussing the potential of primitive IDPs on early Earth, but also the evolution from membraneless to membrane‐bound cells. This review aims to provide a compositional comparison of modern and primitive phase‐separated structures in order to help researchers in both fields understand the current state of knowledge, how this knowledge evolved, and the current gaps that need to be further addressed.
Impact of androgen receptor alterations on cell‐free DNA genomic profiling on survival outcomes in metastatic castration‐resistant prostate cancer
Authors: Tripathi Nishita , Thomas Vinay Mathew , Sayegh Nicolas , Gebrael Georges , Chigarira Beverly , Jo Yeonjung , Li Haoran , Sahu Kamal K. , Nussenzveig Roberto , Nordblad Blake , Swami Umang , Agarwal Neeraj , Maughan Benjamin L. 
Published: August 2023

AbstractBackgroundAndrogen receptor (AR) gene alterations, as detected by circulating tumor cell‐free DNA (cfDNA) genomic profiling, have been shown to emerge after a variable duration of androgen signaling inhibition. AR alterations were associated with inferior outcomes on treatment with androgen receptor pathway inhibitors (ARPI) in the first line metastatic castration‐resistant prostate cancer (mCRPC) setting in a phase 2 trial. Here in, we assessed the impact of these AR alterations on survival outcomes in a real‐world patient population of mCRPC experiencing disease progression on an ARPI.MethodsIn this IRB‐approved retrospective study, consecutively seen patients with a confirmed diagnosis of mCRPC, with disease progression on a treatment with ARPIs in the first line mCRPC setting, with no prior exposure to an ARPI in the castration sensitive setting, and with available cfDNA profiling from a CLIA certified laboratory were included. Patients were categorized based on AR status: wild‐type (ARwt) or alteration‐positive (AR+). The objective was to correlate overall survival (OS) after disease progression on the first‐line ARPI with the presence or absence of AR alterations. Kaplan–Meier and Cox Regression Tests were used as implemented in R‐Studio (v.4.2).ResultsA total of 137 mCRPC patients were eligible: 69 with ARwt versus 68 with AR+. The median OS posttreatment with the first ARPI was significantly higher for ARwt than AR+ patients (30.1 vs. 15.2 mos; p < 0.001). Of 108 patients who received a subsequent line of therapy, 63 received an alternate ARPI (AR+ 39 vs. 24 ARwt), while 20 received a taxane‐based therapy (11 AR+ vs. 9 ARwt). Among patients receiving an alternate ARPI, AR+ had numerically shorter OS (16.8 vs. 30.4 mos, p = 0.1). Among patients receiving taxane‐based regimens, the OS was not significantly different between AR+ and ARwt (14.5 vs. 10.1 mos, p = 0.18).ConclusionIn this real‐world study, mCRPC patients with AR alterations on cfDNA had inferior OS after disease progression on the first ARPI, compared to those who did not, and may impact outcomes on a subsequent ARPI but not on subsequent taxane‐based therapy received. By providing survival estimates for patients with or without AR alterations, our data may aid in patient counseling, prognostication, treatment decision, and for designing future clinical trials in this setting.
Rational peptide design for targeting cancer cell invasion
Authors: Gomari Mohammad Mahmoudi , Arab Seyed Shahriar , Balalaie Saeed , Ramezanpour Sorour , Hosseini Arshad , Dokholyan Nikolay V. , Tarighi Parastoo 
Published: August 2023

AbstractCell invasion is an important process in cancer progression and recurrence. Invasion and implantation of cancer cells from their original place to other tissues, by disabling vital organs, challenges the treatment of cancer patients. Given the importance of the matter, many molecular treatments have been developed to inhibit cancer cell invasion. Because of their low production cost and ease of production, peptides are valuable therapeutic molecules for inhibiting cancer cell invasion. In recent years, advances in the field of computational biology have facilitated the design of anti‐cancer peptides. In our investigation, using computational biology approaches such as evolutionary analysis, residue scanning, protein–peptide interaction analysis, molecular dynamics, and free energy analysis, our team designed a peptide library with about 100 000 candidates based on A6 (acetyl‐KPSSPPEE‐amino) sequence which is an anti‐invasion peptide. During computational studies, two of the designed peptides that give the highest scores and showed the greatest sequence similarity to A6 were entered into the experimental analysis workflow for further analysis. In experimental analysis steps, the anti‐metastatic potency and other therapeutic effects of designed peptides were evaluated using MTT assay, RT‐qPCR, zymography analysis, and invasion assay. Our study disclosed that the IK1 (acetyl‐RPSFPPEE‐amino) peptide, like A6, has great potency to inhibit the invasion of cancer cells.
Multistability in a coupled ocean–atmosphere reduced‐order model: Nonlinear temperature equations
Authors: Hamilton Oisín , Demaeyer Jonathan , Vannitsem Stéphane , Crucifix Michel 
Published: August 2023

AbstractMultistabilities in the ocean–atmosphere flow were found in a reduced‐order ocean–atmosphere coupled model, by solving the nonlinear temperature equations numerically. In this article, we explain how the full nonlinear Stefan–Bolzmann law was implemented numerically and the resulting change to the system dynamics was compared with the original model where these terms were linearised. Multiple stable solutions were found that display distinct ocean–atmosphere flows, as well as different Lyapunov stability properties. In addition, distinct low‐frequency variability (LFV) behaviour was observed in multiple attractors. We investigated the impact on these solutions of changing the magnitude of the ocean–atmospheric coupling, as well as the atmospheric emissivity, to simulate an increasing greenhouse effect. Where multistabilities exist for fixed parameters, the possibility for tipping between solutions was investigated, but tipping did not occur in this version of the model where there is a constant solar forcing. This study was undertaken using a reduced‐order coupled quasigeostrophic ocean–atmosphere model.
Challenges, needs, and rights of Transgender people: An insight
Authors: Kumar Naina 
Published: August 2023

AbstractEvery human has the right to live with respect and dignity, and no one should be discriminated against based on their gender or sexual preferences. Transgender people feel and live as the opposite gender compared to the one assigned at birth. Transgender people face problems in schools, workplaces, public places, accommodations, and healthcare services and are sometimes mocked. Present review briefs on issues faced by Transgenders, problems, and their rights. Literature from 2005 till March 2023 was searched from various organizations and peer‐reviewed journals through PubMed, Google Scholar, and SCOPUS databases using search terms Transgender Persons, Gender nonconforming, Discrimination against Transgender, Right to Health for Transgender, and Laws for Transgender. A total of 55 articles focused on Transgender and their issues were included for analysis. Transgender people have identity issues. It is not a stigma to be ashamed of. On the contrary, they should be appreciated for coming forward and accepting that they are not comfortable with the gender assigned to them. They should be supported in every way to lead a better life. Attempts should be made to stop their harassment, humiliation, and discrimination from using basic needs services and the right to healthcare.
A survey on secure metadata of agile software development process using blockchain technology
Authors: Nayaka Sheetakallu Krishnaiah Parikshith , Narayan Dayanand Lal , Sutradhar Kartick 
Published: August 2023

AbstractScrum is an important and essential technique for developing software. Scrum framework is a project management technique that can emphasize software development teamwork. If you are starting, consider scrum as a method for accomplishing tasks as a team in manageable chunks simultaneously, with ongoing experimentation and feedback loops to learn and improve as you go. Scrum enables individuals and groups to collaboratively and gradually generate value. Being an agile framework, scrum gives people and teams the perfect structure to fit into their workflows while still including the best practices to cater to their requirements. There are some important considerations for security in the agile software development process such as threat modeling, secure coding practices, continuous security testing, authentication, and authorization. In this work, we reviewed various scrum developing techniques to find out the research gaps. This article consider the scrum technique with blockchain technologies for review because it is preferred by most of the software industries.
BRAP silencing protects against neuronal inflammation, oxidative stress and apoptosis in cerebral ischemia–reperfusion injury by promoting PON1 expression
Authors: Kang Tao , Qin Xiao , Lei Qi , Yang Qian 
Published: August 2023

AbstractBackgroundBRCA1 associated protein (BRAP) participates in the regulation of myocardial infarction and atherosclerosis. But the function of BRAP in cerebral ischemia–reperfusion (CIR) injury has not been elucidated yet.MethodsBRAP expression in PC12 cells in response to oxygen–glucose deprivation/reoxygenation (OGD/R) treatment was examined with Western blot assay. PC12 cells underwent OGD/R‐treatment and were subsequently transfected with pcDNA‐BRAP or sh‐BRAP, followed by determination of viability, lactate dehydrogenase (LDH) production, apoptosis, inflammatory cytokine secretion, and oxidative stress marker protein levels. Paraoxonase 1 (PON1) promoter methylation was evaluated with methylation‐specific PCR assay. the effect of BRAP/PON1 axis on CIR injury was investigated by rescue experiments. Additionally, sh‐BRAP was injected into a middle cerebral artery occlusion (MCAO) rat model, and the changes of neurological damage were evaluated.ResultsBRAP overexpression exacerbated OGD/R‐induced viability reduction, LDH production, apoptosis, inflammatory cytokine secretion and oxidative stress in PC12 neuronal cells. In contrast, BRAP silencing showed the opposite results. Mechanistically, BRAP reduced PON1 expression by promoting DNA methyl transferase1 (DNMT1)‐mediated PON1 promoter methylation. PON1 silencing reversed BRAP‐mediated neuroprotection. Additionally, BRAP silencing alleviated CIR‐induced neurological damage in MCAO rats.ConclusionBRAP silencing suppressed OGD/R‐induced neuronal apoptosis, inflammation, and oxidative stress, and alleviated CIR‐induced neurological damage in MCAO rats through facilitating PON1 expression.
On the gauge-invariance of SCET beyond leading power
Authors: Böer Philipp , Hager Patrick 
Published: August 2023

Abstract
We point out that the gauge-invariance of the subleading Lagrangian of soft-collinear effective theory is realised in an intricate way through momentum-conservation violating contributions. Although these terms are disregarded in diagrammatic calculations, the gauge invariance of any physical transition amplitude is preserved due to the soft equations of motion. When not working with gauge-invariant building blocks, individual manifestly gauge-invariant constituent terms in the Lagrangian may give rise to gauge-dependent matrix elements starting at $$ \mathcal{O} $$
O
(λ2). Implications for a gauge-invariant definition of radiative jet functions are discussed.
The role of A$$\beta $$ and Tau proteins in Alzheimer’s disease: a mathematical model on graphs
Authors: Bertsch Michiel , Franchi Bruno , Tesi Maria Carla , Tora Veronica 
Published: August 2023

AbstractIn this Note we study a mathematical model for the progression of Alzheimer’s Disease in the human brain. The novelty of our approach consists in the representation of the brain as two superposed graphs where toxic proteins diffuse, the connectivity graph which represents the neural network, and the proximity graph which takes into account the extracellular space. Toxic proteins such as $$\beta $$
β
amyloid and Tau play in fact a crucial role in the development of Alzheimer’s disease and, separately, have been targets of medical treatments. Recent biomedical literature stresses the potential impact of the synergetic action of these proteins. We numerically test various modelling hypotheses which confirm the relevance of this synergy.