bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rubiadin Regulates Bone Metabolism in Ovariectomized Rat Model by Inhibition of osteoclast formation and differentiation
Authors: Huang Hui , Chen Jian , Lin Zhengkun , Lin Xiaomei 
Published: March 2023

AbstractThe present study investigated the effect of rubiadin frommorinda officinalison bone metabolism in an ovariectomized rat model. Results from the MTT test showed that the best drug concentration was 0.6 mg for 24 h (P>0.05). Compared with the Control group, the femoral bone mineral density in the experimental group treated with rubiadin was significantly higher (P<0.05). After the intervention of rubiadin, the level of P1NP in serum increased, the level of β‐CTX decreased, and the level of estradiol increased. The up‐regulated genes C−C motif chemokine ligand 2 (CCL2), Inhibitor of Nuclear Factor Kappa B Kinase Subunit Beta (IKBKB), C1q, C6, Suppressor of cytokine signaling1 (SOCS1/3) and Dickkopf‐3 (DKK3) were screened from the data. Down regulated genes wnt6, Sfrp5, COL4A6, Ig like R. The differential genes were detected by RT‐PCR. Compared with the Control group, CCL2 and SOCS3 were significantly up‐regulated in the experimental group (P<0.05), and COL4A6 and LILRB3a were significantly down regulated in the experimental group (P<0.05). Western blot test results showed that the expression of LILRB3a protein was significantly reduced, while the expression of SOCS3 protein was significantly increased, indicating that rubiadin could significantly increase the expression of SOCS3 protein and reduce the expression of LILRB3a protein. In conclusion, rubiadin inhibits the formation and differentiation of osteoclasts by affecting the expression of CCL2 and SOCS3, COL4A6 and LILRB3a genes. Therefore, rubiadin can be of therapeutic importance for the treatment of osteoporosis.
Effect of Ce Addition to Ag/ZrO2 Catalyst on the Hydrogenation of DMO to MG
Authors: Wang Xue , Qin Siqian , Zhang Hanqing , Gong Jiang , Shu Weihan , Zhang Chuancai , Wang Denghao , Dai Bin 
Published: March 2023

AbstractMG has a special molecular structure, and MG is an important chemical intermediate with promising applications. Ag−Ce/ZrO2 catalysts with different contents were prepared for hydrogenation of DMO to MG by equal volume impregnation. The content of Ag and the type of additives were screened. According to the effects of different additives on the conversion rate of DMO and the selectivity of MG, Ce was finally selected as the optimal additive metal. These were characterized by XRD, XPS, BET, H2‐TPR. The addition of Ce helps the catalyst to form more oxygen vacancies and Ag2O is more easily reduced to Ag monomers. The performance test results of the catalyst showed that the addition of appropriate amount of Ce has a certain promotion effect on the hydrogenation performance of the catalyst, The yield of MG using the 8Ag−Ce1/ZrO2 catalyst was significantly better than that of the Ag/ZrO2 catalyst.
Constructing Highly Reliable and Adaptive Primary Explosive Composites for Micro‐Initiator Assisting by a Hybrid Template of Metal–Organic Frameworks and Cross‐Linked Polymers
Authors: Fang Zi‐Xin , Wang Chao , Wei Yong‐Li , Wang Qian‐You , Zang Shuang‐Quan 
Published: March 2023

AbstractPrimary explosive, as a reliable initiator for secondary explosives, is the central component of micro‐initiators for modern aerospace systems and military operations. However, they are typically prepared as powders, posing potential safety risks because of the inevitable particles scattering issues in the actual working environments. Here, the fabrication of a highly adaptive bulk material of copper azide (CA)‐based safe primary explosive for micro‐initiators is demonstrated. This bulk material, as derived by a complete azidation reaction of the carbonized metal–organic framework/cross‐linked polymer hybrid template, enables the firm embedding of active CA species in a cross‐linked carbon network (denoted as CA‐C). Interestingly, this CA‐C bulk material demonstrates multifarious mechanical stabilities (e.g., good shock and vibration resistance, and anti‐overload capacity) in the simulated working conditions. Meanwhile, the CA contents in the CA‐C bulk material reached as high as 70.3%, ensuring its detonation power. As a proof of concept, CA‐C bulk material assembling in a micro‐detonator can efficiently detonate the secondary explosive of CL‐20 under laser irradiation. This work hereby advances the fabrication of safe and powerful primary explosives for the fulfillment of safe micro‐initiator in a broad range of applications in aerospace systems.
Building and using nonlinear simulations in Excel with an application to the specific factors model
Authors: Gilbert John , Koska Onur A. , Oladi Reza 
Published: March 2023

AbstractExcel simulation models have become increasingly common in the economics classroom, as their ability to combine numerical and graphical information has proved a useful support to traditional teaching methods. Recent efforts have tended to embed the solution within the Excel sheet, avoiding the need to use the Solver add‐in and allowing changes in the exogenous characteristics of the model to be instantly reflected in the numerical solutions and any associated geometry. While this is quite simple in small‐scale linear models, it is less straightforward in larger nonlinear models such as those that dominate the theory of international trade. We discuss various methods that can be used in building Excel simulations when it is not possible to solve the underlying model explicitly. We illustrate the ideas and describe our experiences along with a new simulation of the specific factors model.
Congestive heart failure secondary to both congenital and acquired defects in a Guernsey heifer
Authors: Upton Kaitlyn E. , Dunham Kylie M. , Di Bernardo Joel P. , Mulon Pierre‐Yves 
Published: March 2023

AbstractA 13‐month‐old Guernsey heifer was admitted on emergency for vague signs of lethargy, bloat, hyporexia and a sudden onset of diarrhoea. On presentation, the heifer was tachycardic, febrile and diffusely oedematous. Bloodwork demonstrated no electrolyte abnormalities, increased liver enzymes, low total protein, increased lactate and a mild leukocytosis characterised by neutrophilia. Ultrasonographic exam revealed the presence of tricavitary effusion, a diffuse, hepatomegaly and an abnormal heart valve. Humane euthanasia was elected and a full autopsy was performed. On postmortem examination, the heart was twice the normal size and had two congenital defects, a ventricular septal defect and pulmonic valve leaflet atresia. Two valvular myxomas were present in the area of the pulmonic valve and likely contributed to further cardiac damage. Final postmortem diagnosis was congestive heart failure secondary to congenital heart defects and valvular myxomas. A postmortem serum cardiac troponin I was likely indicative of myocardial injury.
Aerodynamic performance of a dual turbine concept characterized by a relatively close distance between rotors
Authors: Mendoza Victor , Katsidoniotaki Eirini , Florentiades Markos , Dot Fraga Jorge , Dyachuk Eduard 
Published: March 2023

AbstractIn this work, a closely spaced dual turbine concept is studied. The distance between the two side‐by‐side hubs is 1.05
, where
is the rotor diameter. This configuration has a potential benefit for offshore wind developments in which power density can be maximized. The main goal is to evaluate the overall aerodynamic performance, blade loads, and wake structure of a reference wind turbine generator operating within this dual turbine configuration and to compare the effects against those for the typical single turbine configuration. For this purpose, an actuator line model has been employed together with the large eddy simulation approach for predicting the turbulence effects. This model was implemented by using the open‐source computational fluid dynamics toolbox OpenFOAM. Results show a better performance for the dual turbine concept. Under same operating conditions, the aerodynamic power of each turbine within the dual concept is higher than the power of the stand alone turbine, particularly at lower operating wind speeds (approximately 2% to 3% of extra power per turbine). Comparison between the two configurations shows similar character of the tangential and normal forces acting on the blades in terms of magnitude and fluctuation, eliminating potential concerns regarding fatigue and blade design. The largest difference in the tangential and normal root bending moments are approximately 3% and 2%, respectively, between single and dual turbine configurations. Finally, wake recovery analysis shows a downwind velocity deficit that is not enhanced streamwise in the dual turbine configuration with no considerable difference after 7
.
D-ärztlich veranlasste Psychotherapie
Authors: Jugert Josephine , Schröder Stefan G. , Drechsel-Schlund Claudia , Angerer Peter 
Published: March 2023

Zusammenfassung
Hintergrund
Deutschlandweit liegt mit etwa 1 Mio. pro Jahr die Zahl von Arbeits- und Wegeunfällen seit Jahren konstant hoch, aktuell allerdings pandemiebedingt niedriger, aufgrund von partiellen Betriebsschließungen, Lockdown-Maßnahmen und der Zunahme von Arbeit aus dem „Homeoffice“.

Fragestellung
Die Deutsche Gesetzliche Unfallversicherung e. V. (DGUV; gemeinsamer Spitzenverband der Unfallversicherungsträger) hat 2012 mit dem sog. Psychotherapeutenverfahren ein Instrument zur Förderung und zur Regulierung fachkundiger Versorgung psychischer Unfallfolgen geschaffen. Wie ist diese Regelung angenommen worden? Welche Fallkonstellationen werden beobachtet?

Material und Methode
Nationale Daten zur Nutzung des Psychotherapeutenverfahrens bei Arbeits- und Wegeunfällen werden rückblickend für die Jahrgänge 2013–2021 vorgestellt, exemplarisch auch regionale, inklusive Fallskizzen (aus Güstrow).

Ergebnisse
Deutschlandweit hat sich im betrachteten Zeitraum der Prozentsatz der Psychotherapien von 0,47 auf 0,96 % verdoppelt.

Diskussion
Die 10-Jahresbilanz ist positiv, das Psychotherapeutenverfahren wird offensichtlich gut angenommen. Der tatsächliche Psychotherapiebedarf lässt sich nur aus Einzelstudien abschätzen, repräsentative Studien fehlen. Interdisziplinäres klinisches und wissenschaftliches Engagement für die Psychotraumatisierten ist notwendig und zu optimieren. Grundwissen in Psychotraumatologie ist daher bereits für die D‑Arzt-Medizin in den unfallchirurgischen Weiterbildungskatalog aufgenommen worden.
Trends in hospital admissions among children with asthma in Spain (2011–2020)
Authors: Gutierrez-Albaladejo Natalia , Jimenez-Garcia Rodrigo , Albaladejo-Vicente Romana , Villanueva-Orbaiz Rosa , de-Miguel-Diez Javier , Noriega Concepción , Lopez-de-Andres Ana 
Published: March 2023

AbstractThe purpose of this study is to describe and assess changes in incidence, clinical conditions, use of mechanical ventilation, length of hospital stay (LOHS), and in-hospital mortality (IHM) among children hospitalized with asthma in Spain from 2011 to 2020. We analyzed children aged 0 to 15 years hospitalized with an ICD code for asthma included in the Spanish National Hospital Discharge Database (SNHDD). The analysis was conducted for asthma as the primary diagnosis and with asthma in any diagnosis position. Joinpoint regression was used to assess time trends in incidence. We included a total of 85,664 children hospitalized with asthma; of these, 46,727 (54.55%) had asthma coded as the primary diagnosis. The number of boys was higher than the number of girls, irrespective of age group or diagnostic position. The frequency of asthma as primary diagnosis decreased from 55.7% in 2011 to 43.96% in 2020 (p < 0.001). The incidence of hospitalizations because of asthma decreased significantly from 2011 to 2020, with a faster decrease from 2018 onwards. Over time, the proportion of older children increased. In the year 2020, only 55 children had codes for asthma and COVID-19 in their discharge report, and this infection had no effect on hospitalizations this year. A significant increase in the use of non-invasive ventilation (NIV) was observed over time. Irrespective of the diagnostic position, LOHS and IHM remained stable over time, with the IHM under 0.1%. Conclusion: Our results show a decrease in the incidence of hospital admissions with asthma either as the primary diagnosis or in any position. The age of children hospitalized seems to be increasing as the use of NIV. Better management of the disease from primary care and the emergency department as is the use of NIV could explain the reduction in incidence.

What is Known:

• Asthma is the most common chronic respiratory in childhood in high income countries.

• The incidence of hospital admissions with asthma and associated factors is one of the best sources of information on morbidity trends and prognosis.

What is New:

• The incidence of hospital admissions for asthma in Spain decreased in children between 2011 and 2020 with a more frequent use of non-invasive mechanical ventilation and low mortality rates.

• COVID-19 did not cause an increase in admissions with asthma in the year 2020.
Metaphern am Lebensende: Resilienz als Widerstand oder Akzeptanz
Authors: Koller Veronika 
Published: March 2023

ZusammenfassungDer Beitrag bietet eine Übersicht über das Forschungsprojekt „Metaphern in der Betreuung am Lebensende“, das von 2011 bis 2014 an der Universität Lancaster in Großbritannien durchgeführt wurde. Zielsetzung des Projekts war es zu zeigen, a) wie Patient*innen, Familienangehörige und Gesundheitspersonal Metaphern verwenden, um über ihre Erfahrungen mit und Erwartungen an Betreuung am Lebensende zu sprechen, b) auf welche Erfahrungen und Bedürfnisse dieser Metapherngebrauch hindeutet und c) welchen Beitrag zur Kommunikation im Gesundheitswesen die Ergebnisse leisten können. Ein Korpus, bestehend aus Interviews mit verschiedenen Personengruppen und deren Beiträgen in Internetforen, wurde manuellen und halbautomatischen Analysen unterzogen. Die Ergebnisse zeigen, dass insbesondere die Onlinekommunikation von Patient*innen und Familienangehörigen von Gewalt- und Reisemetaphern geprägt ist. Der Metapherngebrauch dieser Gruppen deutet auf ein Bedürfnis nach Solidarität und Gemeinschaft hin und reflektiert sowohl positive als auch negative Selbsterfahrungen. Resilienz kann als Widerstand gegen Krankheit oder als deren Akzeptanz verstanden werden.
A Review of Cyclist Head Injury, Impact Characteristics and the Implications for Helmet Assessment Methods
Authors: Baker Claire E. , Yu Xiancheng , Patel Saian , Ghajari Mazdak 
Published: March 2023

AbstractHead injuries are common for cyclists involved in collisions. Such collision scenarios result in a range of injuries, with different head impact speeds, angles, locations, or surfaces. A clear understanding of these collision characteristics is vital to design high fidelity test methods for evaluating the performance of helmets. We review literature detailing real-world cyclist collision scenarios and report on these key characteristics. Our review shows that helmeted cyclists have a considerable reduction in skull fracture and focal brain pathologies compared to non-helmeted cyclists, as well as a reduction in all brain pathologies. The considerable reduction in focal head pathologies is likely to be due to helmet standards mandating thresholds of linear acceleration. The less considerable reduction in diffuse brain injuries is likely to be due to the lack of monitoring head rotation in test methods. We performed a novel meta-analysis of the location of 1809 head impacts from ten studies. Most studies showed that the side and front regions are frequently impacted, with one large, contemporary study highlighting a high proportion of occipital impacts. Helmets frequently had impact locations low down near the rim line. The face is not well protected by most conventional bicycle helmets. Several papers determine head impact speed and angle from in-depth reconstructions and computer simulations. They report head impact speeds from 5 to 16 m/s, with a concentration around 5 to 8 m/s and higher speeds when there was another vehicle involved in the collision. Reported angles range from 10° to 80° to the normal, and are concentrated around 30°–50°. Our review also shows that in nearly 80% of the cases, the head impact is reported to be against a flat surface. This review highlights current gaps in data, and calls for more research and data to better inform improvements in testing methods of standards and rating schemes and raise helmet safety.
Examining the Relationship Between HIV-Related Stigma and the Health and Wellbeing of Children and Adolescents Living with HIV: A Systematic Review
Authors: Robinson Abbie , Cooney Aoife , Fassbender Catherine , McGovern David P 
Published: March 2023

AbstractHuman immunodeficiency virus (HIV) affects millions of people globally. The associated stigma remains a challenge for individuals living with HIV and children and adolescents face the additional challenge of withstanding the peer, pubertal and identity challenges associated with growing up. The current systematic review aimed to define and explore the major stigma-related challenges of children and adolescents from their own perspectives. A secondary aim was to identify any challenges distinct to childhood and adolescence. Studies included individuals aged 3 to 18 years who were aware of their status. Fifteen studies met inclusion criteria. Narrative synthesis was conducted on the included studies. Five analytic themes emerged describing major stigma-related challenges: disclosure-related anxiety, medication adherence, feelings of abnormality, mental health issues and social exclusion. Disclosure-related anxiety and feelings of abnormality appeared to be largely confined to the experience of children and adolescents. Many of the themes centred around peer influence, highlighting the need to belong in youth. Results suggest that youth require tailored interventions targeting their age-specific challenges.
Data-driven prototyping via natural-language-based GUI retrieval
Authors: Kolthoff Kristian , Bartelt Christian , Ponzetto Simone Paolo 
Published: March 2023

AbstractRapid GUI prototyping has evolved into a widely applied technique in early stages of software development to facilitate the clarification and refinement of requirements. Especially high-fidelity GUI prototyping has shown to enable productive discussions with customers and mitigate potential misunderstandings, however, the benefits of applying high-fidelity GUI prototypes are accompanied by the disadvantage of being expensive and time-consuming in development and requiring experience to create. In this work, we showRaWi, a data-driven GUI prototyping approach that effectively retrieves GUIs for reuse from a large-scale semi-automatically created GUI repository for mobile apps on the basis of Natural Language (NL) searches to facilitate GUI prototyping and improve its productivity by leveraging the vast GUI prototyping knowledge embodied in the repository. Retrieved GUIs can directly be reused and adapted in the graphical editor ofRaWi. Moreover, we present a comprehensive evaluation methodology to enable (i) the systematic evaluation of NL-based GUI ranking methods through a novel high-quality gold standard and conduct an in-depth evaluation of traditional IR and state-of-the-art BERT-based models for GUI ranking, and (ii) the assessment of GUI prototyping productivity accompanied by an extensive user study in a practical GUI prototyping environment.
Event-Related Potentials Index Prediction Error Signalling During Perceptual Processing of Emotional Facial Expressions
Authors: Baker Kristen S. , Johnston Patrick , Yamamoto Naohide , Pegna Alan J. 
Published: March 2023

AbstractHumans use socially relevant stimuli to guide perceptual processing of the surrounding environment, with emotional stimuli receiving preferential attention due to their social importance. Predictive coding theory asserts this cognitive process occurs efficiently by combining predictions about what is to be perceived with incoming sensory information, generating prediction errors that are then used to update future predictions. Recent evidence has identified differing neural activity that demonstrates how spatial and feature-based attention may interact with prediction, yet how emotion-guided attention may influence this relationship remains unknown. In the present study, participants viewed a display of two faces in which attention, prediction, and emotion were manipulated, and responded to a face expressing a specific emotion (anger or happiness). The N170 was found to be enhanced by unpredictable as opposed to predictable stimuli, indicating that it indexes general prediction error signalling processes. The N300 amplitudes were also enhanced by unpredictable stimuli, but they were also affected by the attentional status of angry but not happy faces, suggesting that there are differences in prediction error processes indexed by the N170 and N300. Overall, the findings suggest that the N170 and N300 both index violations of expectation for spatial manipulations of stimuli in accordance with prediction error responding processes.
Imparting cotton textiles glow-in-the-dark property along with other functional properties: photochromism, flame-retardant, water-repellency, and antimicrobial activity
Authors: Ahmed Esraa , Maamoun Dalia , Abdelrahman Meram S. , Hassan Talaat M. , Khattab Tawfik A. 
Published: March 2023

AbstractScreen-printing and spray-coating methods were used to produce photoluminescent, water-repellent, and antimicrobial films on textile fibers. The cotton fabrics were firstly finished with a flame-resistant agent. There are a number of functional agents that have been applied during the textile finishing process, including strontium aluminate pigment as antibacterial and photoluminescent agent, flame-retardant organophosphate, and water-repellent silicone rubber. The current research investigated the surface morphologies and chemical compositions of the screen-printed and spray-coated fabric cottons using scanning electron microscopy (SEM), transmission electron microscopy (TEM), energy-dispersive X-ray (EDX), wavelength dispersive X-ray fluorescence (WDXRF), and Fourier-transform infrared spectroscopy (FT-IR). According to morphological analysis, the phosphor nanoparticles had sizes ranging from 2 to 12 nm. After excitation at 399 nm, the generated colorless photoluminescent layer deposited onto cotton surface showed an emission profile at 516 nm. The luminescence spectra and CIE Lab characteristics confirmed that the phosphor-coated textiles displayed a white color in visible spectrum and green emission in the presence of UV light. It has been shown by analysis that the tested colors are very stable over time. The measurements of static water contact and sliding angles were also explored. The self-extinguishing activity of the coated fabrics retained their flame-retardant properties over 24 laundry cycles. Antimicrobial activity, hydrophobicity, and luminous properties were improved without affecting the intrinsic physical and mechanical features of the treated textiles. Details on the CIE Lab colorimetric measurements were discussed. The stiffness and air permeability were examined to explore the flexibility and breathability of the treated textile fibers. Excellent reversibility and photostability were seen in the phosphor-coated materials.
Stable Voting
Authors: Holliday Wesley H. , Pacuit Eric 
Published: March 2023

AbstractWe propose a new single-winner voting system using ranked ballots: Stable Voting. The motivating principle of Stable Voting is that if a candidate A would win without another candidate B in the election, and A beats B in a head-to-head majority comparison, then A should still win in the election with B included (unless there is another candidate $$A'$$

A
′

who has the same kind of claim to winning, in which case a tiebreaker may choose between such candidates). We call this principle Stability for Winners (with Tiebreaking). Stable Voting satisfies this principle while also having a remarkable ability to avoid tied outcomes in elections even with small numbers of voters.