bluuebunny/crossref_metadata_2025_split huggingface dataset:
The In silico and In vitro Anti-inflammatory and Antibacterial Activities of
Flavonoids from Artemisia vulgaris in Vietnam
Authors: Trinh Pham Thi Nhat , An Tran Nguyen Minh , Danh Tong Thanh , Nguyen Thi Hong Anh , Nguyen Van-Kieu , Duong Thuc-Huy , Dung Le Tien 
Published: September 2023

Abstract:
Artemisia vulgaris is used to treat rheumatism, scabies, and trauma-related pain in
traditional Vietnamese medicine. However, there is a lack of in vitro and in silico studies on the
antibacterial and anti-inflammatory effects of Artemisia vulgaris in Vietnam. Method: This research
was designed to evaluate the bioactivities of extracts and isolated flavonoids from this
plant. The results indicated that crude extract (AVE) and sub-fractions (hexane - AVH; ethyl
acetate - AVEA; and methanol - AVM) showed a strong suppression of nitric oxide creation and
proinflammatory TNF-α secretion in LPS-activated RAW 264.7 macrophages. Moreover, AVE,
AVEA, and AVH demonstrated moderate antibacterial activity against Methicillin-resistant
Staphylococcus aureus and Pseudomonas aeruginosa strains with MICs of 2 mg/mL. Among
five isolated flavonoids (1-5), apigenin (1) attenuated LPS-induced inflammation in RAW 264.7
macrophages by downregulating TNF-a and NO production, while apigenin (1) and luteolin (2) were the effective
inhibitors of MRSA and P. aeruginosa strains. Result: These results are in accordance with in-silico molecular
docking investigations. Among docking poses of compounds (1-5), pose 483, the best docking pose among 500
docking conformations of compound apigenin (1), has been docked to the 4WCU:PDB enzyme with the values of
the binding affinity and inhibition constant of -7.27 Kcal.mol-1 and 4.73 μM, respectively and proved to be the best
anti-inflammatory compound that linked well to this enzyme and was responsible for explaining anti-inflammatory
activity. In silico docking to explain why luteolin (2) inhibits bacteria via a general enzyme inhibition mechanism,
glucosamine-6-phosphate synthase: 2VF5. Luteolin (2) or pose 148 anchored well to 2VF5 with binding affinity
and inhibition constants of -6.90 Kcal.mol-1 and 8.80 μM, respectively. Conclusion: The study demonstrated that
apigenin, or pose 483, was an excellent anti-inflammatory compound with meta-hydroxy in ring B, while luteolin,
or pose 148, with orto-hydroxy in ring B, exhibited good anti-bacterial activity.
Synthesis and Medicinal Applications of Fenamic Acid Derivatives
Authors: Sharma Mousmee , Prasher Parteek 
Published: September 2023

Abstract:
Fenamic acid-derived NSAIDs contain N-phenyl anthranilic acid as a pharmacophore with pKa ~ 4,
which is completely ionized at the physiological pH and is mainly excreted in the urine by hydroxylation or glucuronidation. The acid (-COOH) functionality in fenamic acid provides a template for their fenamate derivatization
for the development of analogues based on amidation, esterification, and etherification. Besides the repurposing of
fenamates as neuroprotective agents in unmodified form, several of their derivatives have been reported for the
management of disease pathogenesis by regulating the responsible pathways. In this review, we discuss the chemical modification of fenamic acid and its medicinal chemistry thereof.
Ebselen: A Review on its Synthesis, Derivatives, Anticancer Efficacy and
Utility in Combating SARS-COV-2
Authors: Ali Farak , Alom Shahnaz , Ali Sheikh Rezzak , Kondoli Biswanarayan , Sadhu Prativa , Borah Chinmoyee , Kakoti Bibhuti Bushan , Ghosh Surajit Kumar , Shakya Anshul , Ahmed Abdul Baquee , Singh Udaya Pratap , Bhat Hans Raj 
Published: September 2023

Abstract:
Ebselen is a selenoorganic chiral compound with antioxidant properties comparable to glutathione
peroxidase. It is also known as 2-phenyl-1,2-benzisoselenazol-3(2H)-one. In studies examining
its numerous pharmacological activities, including antioxidant, anticancer, antiviral, and anti-
Alzheimer’s, ebselen has demonstrated promising results. This review's primary objective was to emphasize
the numerous synthesis pathways of ebselen and their efficacy in fighting cancer. The data
were collected from multiple sources, including Scopus, PubMed, Google Scholar, Web of Science,
and Publons. The starting reagents for the synthesis of ebselen are 2-aminobenzoic acid and N-phenyl
benzamide. It was discovered that ebselen has the ability to initiate apoptosis in malignant cells and
prevent the formation of new cancer cells by scavenging free radicals. In addition, ebselen increases
tumor cell susceptibility to apoptosis by inhibiting TNF-α mediated NF-kB activation. Ebselen can
inhibit both doxorubicin and daunorubicin-induced cardiotoxicity. Allopurinol and ebselen administered
orally can be used to suppress renal ototoxicity and nephrotoxicity. Due to excessive administration,
diclofenac can induce malignancy of the gastrointestinal tract, which ebselen can effectively
suppress. Recent research has demonstrated ebselen to inhibit viral function by binding to cysteinecontaining
catalytic domains of various viral proteases. It was discovered that ebselen could inhibit
the catalytic dyad function of Mpro by forming an irreversible covalent bond between Se and Cys145,
thereby altering protease function and inhibiting SARS-CoV-2. Ebselen may also inhibit the activation
of endosomal NADPH oxidase of vascular endothelial cells, which is believed to be required for
thrombotic complications in COVID-19. In this review, we have included various studies conducted
on the anticancer effect of ebselen as well as its inhibition of SARS-CoV-2.
The Association between Circulating Adipocytokine Omentin Levels and Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-analysis
Authors: Khodashahi Rozita , Aliakbarian Mohsen , Ferns Gordon A , Arjmand Mohammad-Hassan 
Published: September 2023

Background:
Nonalcoholic fatty liver disease (NAFLD) is the most common
chronic liver condition worldwide. NAFLD is often associated with features of Metabolic
Syndrome such as obesity and insulin resistance.

Methods:
The current comprehensive meta-analysis was performed to evaluate the
association between circulating Omentin levels and NAFLD. A systematic search in
Scopus, Web of Science, PubMed, and Google Scholar databases was conducted to
identify relevant studies up until 5th May 2022. The standard mean difference (SMD)
values and 95% confidence intervals (CIs) were computed for the association of
Omentin levels with NAFLD risk in a random effect model.

Results:
The meta-analysis involved 6 case-control studies with a total of 371 cases
and 269 controls. Pooled SMD showed no significant difference in serum Omentin
between NAFLD and healthy groups (SMD= -0.047 and 95% CI -0.957_0.862 P=0.91).
Subgroup analysis based on sample size showed that the average Omentin levels were
significantly higher in NAFLD patients in studies with sample size ≥70 (SMD=0.356 CI
0.056_0.655 P=0.02).

Conclusion:
Additional well-designed studies with more sample sizes are essential to
clarify the potential role of Omentin as a risk marker of NAFLD.
Differential Diagnosis or Etiology: A Case Report on Amyotrophic Lateral Sclerosis-like Neuropathy Associated with HIV Infection
Authors: Rodrigues Renato Barradas , Orsini Marco , Neves Sofia Vieira , de Rezende Pinto Wladimir Bocca Vieira , da Silva Catarino Antônio Marcos , Antunes Pereira Daniel , Oliveira Acary Souza Bulle 
Published: September 2023

Background:
Retroviruses are described as a risk factor for chronic neuropathy. However,
it is still unknown if they can work as amyotrophic lateral sclerosis triggers. Over the years,
some cases of this association have been described with heterogenous disclosures.

Case Representation:
This study aimed to report a case of HIV and ALS-like neuropathy and briefly
discuss peculiarities of clinical aspects, such as physiopathology and treatment options. The patient
underwent neurological examination associated with blood tests, electromyography, analysis
of cerebrospinal fluid, and imaging studies.

Discussion:
A non-systematic review was performed in major databases regarding the topic. The
case presented mixed upper and lower motor neuron signs and was framed as a probable case of
ALS following the present criteria.

Conclusion:
After a short follow-up and viral load cleansing, neurological stabilization was
achieved.
Comparative Efficacy of Endogenous Stem Cells Recruiting Hydrogels
and Stem Cell-loaded Hydrogels in Knee Cartilage Regeneration: A
Meta- analysis
Authors: Feng Wanyun , Zhu Chaohua , Miao Ruoxiang , Li Danni , Xiong Xi , Wang Ruyu , Liu Guobin , Ma Jun 
Published: September 2023

Background:
Cartilage defects remain a challenge in diseases such as osteoarthritis
(OA) and fractures. Scientists have explored the use of hydrogels in conjunction with stem cell
technology as a tissue engineering method to treat cartilage defects in joints. In recent years, research
into hydrogels containing stem cell technology for cartilage repair has mainly focused on
two categories: stem cell-loaded hydrogels and endogenous stem cell recruiting hydrogels. The latter,
utilizing cell-free products, represents a novel concept with several advantages, including easier
dose standardization, wider sources, and simpler storage. This meta-analysis aims to assess and
compare the therapeutic effects of endogenous stem cell recruiting hydrogels and stem cell-loaded
hydrogels in promoting articular cartilage regeneration in animal models, with the goal of exploring
endogenous stem cell recruiting hydrogels as a promising replacement therapy for knee cartilage
regeneration in preclinical animal studies.

Methods:
We systematically searched PubMed, Web of Science, Cochrane Library, and Embase
until January 2023 using key words related to stem cells, cartilage regeneration and hydrogel. A
random-effects meta-analysis was performed to evaluate the therapeutic effect on newborn cartilage
formation. Stratified analyses were also carried out by independently classifying trials according
to similar characteristics. The level of evidence was determined using the GRADE method.

Results:
Twenty-eight studies satisfied the inclusion criteria. Comprehensive analyses revealed
that the use of endogenous stem cell recruiting hydrogels significantly promoted the formation of
new cartilage in the knee joint, as evidenced by the histological score (3.77, 95% CI 2.40, 5.15; p <
0.0001) and the International Cartilage Repair Society (ICRS) macroscopic score (3.00, 95% CI
1.83, 4.18; p = 0.04), compared with the control group. The stem cell-loaded hydrogels also increased
cartilage regeneration in the knee with the histological score (3.13, 95% CI 2.22, 4.04; p =
0.02) and the ICRS macroscopic score (2.49, 95% CI 1.16, 3.82; p = 0.03) in comparison to the
control. Significant heterogeneity between studies was observed, and further stratified and sensitivity
analyses identified the transplant site and modelling method as the sources of heterogeneity.

Conclusion:
The current study indicates that both endogenous stem cell recruiting hydrogels and
stem cell loaded hydrogels can effectively promote knee joint cartilage regeneration in animal
trials.

Prospero Registration Number::
CRD42022348526.
Predicting the Risk of Breast Cancer Recurrence and Metastasis based on
miRNA Expression
Authors: Lv Yaping , Wang Yanfeng , Zhang Yumeng , Chen Shuzhen , Yao Yuhua 
Published: September 2023

Background:
Even after surgery, breast cancer patients still suffer from recurrence and
metastasis. Thus, it is critical to predict accurately the risk of recurrence and metastasis for individual
patients, which can help determine the appropriate adjuvant therapy.

Methods:
The purpose of this study is to investigate and compare the performance of several categories of molecular biomarkers, i.e., microRNA (miRNA), long non-coding RNA (lncRNA), messenger RNA (mRNA), and copy number variation (CNV), in predicting the risk of breast cancer recurrence and metastasis. First, the molecular data (miRNA, lncRNA, mRNA, and CNV) of 483 breast
cancer patients were downloaded from the Cancer Genome Atlas, which were then randomly divided
into the training and test sets with a ratio of 7:3. Second, the feature selection process was applied by
univariate Cox and multivariate Cox variance analysis on the training set (e.g., 15 miRNAs). According to the selected features (e.g., 15 miRNAs), a random forest classifier and several other classification methods were established according to the label of recurrence and metastasis. Finally, the performances of the classification models were compared and evaluated on the test set.

Results:
The area under the ROC curve was 0.70 for miRNA, better than those using other biomarkers.

Conclusion:
These results indicated that miRNA has important guiding significance in predicting
recurrence and metastasis of breast cancer.
The Efficacy of Colchicine as an Adjunct Therapy in
Non-hospitalized COVID-19 Patients: A Randomized
Placebo-Controlled Trial
Authors: Hejazi Sepideh , Jahani Zohreh , Elyasi Sepideh , Salarbashi Davoud , Kabiri Mona 
Published: September 2023

Background:
The therapeutic potential of oral colchicine administration may help
combat COVID-19 infection due to reduced disease severity and mortality risk.

Objective:
This randomized trial aimed to assess the effect of colchicine treatment on the inflammatory
and hematologic markers as well as clinical features in non-hospitalized patients
with mild-to-moderate COVID-19 disease.

Method:
In the present placebo-controlled randomized trial, 80 non-hospitalized COVID-19
patients were enrolled and followed for 14 days. Subjects randomly received oral colchicine
or placebo tablets once a day for two weeks. The fever and cough clinical signs, as well as Creactive
protein (CRP) and lymphopenia, were evaluated through the follow-up.

Results:
No significant between-group differences were observed in terms of the duration of
clinical symptoms, CRP, and lymphopenia at 0, 7, and 14 days of intervention. Although the
proportion of participants with fever, cough, positive CRP, and lymphopenia was higher reduced
in the colchicine group than the placebo during treatment, no significant differences
were found between groups. Due to no adverse effects detected in this trial, colchicine therapy
was well-tolerated and safe.

Conclusion:
Our findings revealed that colchicine adjuvant therapy had no beneficial effect
on clinical and para-clinical parameters in non-hospitalized COVID-19 patients during 14
days of intervention. The present trial does not support colchicine as a potential treatment
against COVID-19 disease.

Clinical trial Registration:
The present study protocol was approved by the IRCT
(IRCT20200408046990N2, https://en.irct.ir/trial/47468).
Characteristics of Complement Protein Deposition in Proliferative Glomerulonephritis with Monoclonal Immunoglobulin Deposition
Authors: Liu Meng-yao , Yu Xiao-juan , Wang Su-xia , Li Yuan , Xing Guo-lan , Chen Ming , Zhou Fu-de , Zhao Ming-hui 
Published: September 2023

Background
Hypocomplementemia and complement co-deposition with monoclonal immunoglobulins in glomeruli are not rare in proliferative glomerulonephritis with monoclonal immunoglobulin deposits (PGNMID). Deposition of monoclonal immunoglobulins in glomeruli has been suggested to activate complement and cause kidney injury. However, the profiles of complement activation in PGNMID and their clinical and pathologic significance need to be clarified.

Methods
Forty-six patients with PGNMID were enrolled. Proteomic analysis of glomeruli using laser microdissection and mass spectrometry was performed for ten patients with PGNMID to determine the composition of glomerular deposits. Kidney deposition of complement components was detected by immunohistochemistry and immunofluorescence. Urinary and plasma levels of complement components were measured by an enzyme-linked immunosorbent assay. Group differences were assessed using t tests or Mann–Whitney U tests depending on the distribution. Correlation analysis was performed using Spearman rank correlation or Pearson correlation.

Results
Laser microdissection and mass spectrometry–based proteomic analysis showed that complement components were the most enriched proteins deposited in the glomeruli of patients with PGNMID. Glomerular deposition of C3c, C4d, and C5b-9 was detected in most patients. Levels of urinary and plasma C3a, C5a, soluble C5b-9, C4d, Bb, and C1q as well as urinary mannose-binding lectin were significantly higher in patients with PGNMID compared with healthy controls. The intensity of C3c and C4d deposition in glomeruli correlated with serum creatinine and the percentage of crescents, respectively. Furthermore, levels of urinary complement components correlated positively with serum creatinine, urinary protein excretion, percentage of crescents, and global glomerulosclerosis in kidney biopsies, whereas plasma levels of most complement components did not show a significant correlation with clinicopathologic parameters. In multivariable analysis, a higher level of urinary C4d was identified as an independent risk factor of kidney failure.

Conclusions
The complement system was found to be overactivated in PGNMID, and levels of urinary complements correlated with disease severity. A higher level of urinary C4d was identified as an independent risk factor of kidney failure.
TYPES OF SYNTACTICAL ERRORS MADE BY ENGLSIH DEPARTMENTS STUDENTS IN WRITING ESSAY REGISTERED 2014/2015 ACADEMIC YEAR AT STAIN BATUSANGKAR
Authors: Putra Hendra 
Published: September 2023

<p><strong><em>Hendra Putra,2015. </em></strong><strong><em>Types of Syntactical Errors Made by English Department Students in Writing Essay Registered 2014/2015 Academic Years at Stain Batusangkar. </em></strong><strong><em>Thesis. Graduate Program. State University of Padang.</em></strong></p><p><strong><em>Â </em></strong></p><p><em>This research deal with types of errors which consist of </em><em>noun phrase, verb phrase, verb and verb construction, some transformation, word order, addition and omission made by the fourth semester students of the English Department of STAIN Batusangkar in writing essays.</em></p><p><em>This research was aimed at finding out and explaining types of errors made by English Department students in writing essay at STAIN Batusangkar in 2014/2015 academic year.</em></p><p><em>The source of data this research was writing test. The technique of data collection was simple random sampling. From the data, the researcher took 23 essays (20%) from the total of students. In analyzing the data, the researcher used some step, mainly reading, describing and classifying the data.</em></p><p><em>The research revealed that there were </em><em>314 errors from studentsâ€™ writing essay. Those errors were noun phrase 80 errors (25.48%), verb phrase 138 errors (43.95%), verb and verb construction 7 errors (2.23%), word order 14 errors (4.46%), some transformation 9 errors (2.87%), omission 43 errors (13.69%), addition 23 errors (7.32%).</em></p><p><em>Based on the finding above, it could be concluded that the students committed the errors in their essays. It might be caused by their grammatical mastery in English. It is also suggested to the lecturers to provide more detail explanations to the students related to the grammar problems so that the students will not make errors in their writing later on or at least it can minimize the errors produced by the students.</em></p>
relevancia de los Sistemas de Gestión de la Calidad en el sector de dispositivos médicos
Authors: Chuco Aguilar Victoria Judith 
Published: September 2023

A medida que avanza la tecnología, se han ido fabricando dispositivos médicos cada vez más sofisticados, lo que ha provocado un aumento de la oferta en el mercado. Sin embargo, la proliferación de equipos de mala calidad pone en peligro la salud e, inclusive, la vida de los consumidores. Ante tal situación, la implementación de las normas ISO 13485 y las Buenas Prácticas de Manufactura permite asegurar la calidad en la fabricación de dispositivos médicos, lo cual repercutirá en la confianza del consumidor. Por ese motivo, el objetivo del presente artículo es destacar la relevancia de los Sistemas de Gestión de la Calidad en la industria de los dispositivos médicos. Finalmente, se plantean las conclusiones a ser consideradas en futuras investigaciones.
Antimicrobial Potential Of Endophyte Bacteria In Angsana Plants (Pterocarpus indicus Willd)
Authors: Nurhasnah Nurhasnah , Roza Media , Sari Milya , Kencanawati Kencanawati 
Published: September 2023

The discovery of antimicrobial active compounds is one of the pressing things in the world of medicine and the pharmaceutical industry, due to the increasing and widespread resistance of pathogenic bacteria to existing antimicrobials. Angsana plant (Pterocarpus Indicus Willd) has been shown to have efficacy as a drug, so it has the potential to be used as a source of natural antibiotics. This study aims to find out the types of endophytes in various parts of the Angsana plant (Pterocarpus indicus Willd) through macroscopic and microscopic identification and find out the activity of antimicrobial compound-producing endophye bacteria in Angsana plants. Bacterial purification techniques use streak plate and spread plate methods. Antimicrobial activity tests are carried out using diffusion methods by means of point inoculation. The results showed 29 isolates of endophye bacteria isolated from the Angsana plant (Pterocarpus indicus Willd). From the roots as many as 11 isolates, stems as many as 12 isolates, and leaves as many as 6 isolates. The result of Gram staining of Angsana plant endophyte bacteria, obtained 22 bacterial isolates including Gram positive and 7 is Gram negative. There were 21 bacil-shaped endophyte bacterial isolates, 7 coccus-shaped isolates and 1 coccobacil-shaped isolate. Isolate the endophyte bacteria of Angsana plants that have the potential to produce antimicrobial compounds as many as 20 isolates. Isolates of Angsana plant endophyte bacteria form a bland zone in S. aureus (10 isolates), E. coli (17 isolates). Endophyte bacterial isolates that are able to inhibit the growth of bacteria S. aureus and E. coli are 7 isolates
comedores como dispositivo de política alimentaria durante la pandemia
Authors: Capello Lucia Soledad , Bonet Ana María 
Published: September 2023

El presente trabajo aborda el funcionamiento de los comedores escolares como dispositivo de política pública alimentaria en función del derecho humano a la alimentación adecuada durante la pandemia Covid-19, a partir del caso de tres comedores de San Carlos (Provincia de Santa Fe). Se propone como hipótesis que aún durante la profundización de la crisis alimentaria que implicó la pandemia, los comedores escolares continuaron operando como un mecanismo que sólo alcanzaba a garantizar un primer nivel del derecho humano a la alimentación (entendido como derecho a no sufrir hambre) por su funcionamiento bajo un enfoque focalizado y un abordaje de emergencia. La realización efectiva del derecho a la alimentación en su alcance integral como alimentación adecuada requeriría de una revisión del enfoque cortoplacista de la emergencia en función de otros mecanismos sistémicos que considerendesde la primera instancia una articulación de la heterogeneidad de aspectos nutricionales, culturales, sociales y ambientales que involucra el fenómeno alimentario. En primer lugar, se presenta brevemente el encuadre normativo de los comedores escolares como elemento de las políticas públicas alimentarias en Argentina. Luego, se procura realizar una descripción del funcionamiento de tres comedores situados en localidades vecinas del departamento “Las Colonias”, Provincia de Santa Fe, estos son, los comedores escolares de las escuelas “Lina Beck Bernard” N°2040 (San Carlos Centro); “Bernardino Rivadavia” N°357 (San Carlos Norte) y "Mariano Moreno” N° 326 (San Jerónimo del Sauce). Por último, se analiza reflexivamente el potencial de los comedores escolares como dispositivo para avanzar hacia la realización efectiva del derecho humano a la alimentación adecuada.