bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rare neurovascular genetic and imaging markers across neurodegenerative diseases
Authors: Dilliott Allison A. , Berberian Stephanie A. , Sunderland Kelly M. , Binns Malcolm A. , Zimmer Julia , Ozzoude Miracle , Scott Christopher J. M. , Gao Fuqiang , Lang Anthony E. , Breen David P. , Tartaglia Maria C. , Tan Brian , Swartz Richard H. , Rogaeva Ekaterina , Borrie Michael , Finger Elizabeth , Fischer Corinne E. , Frank Andrew , Freedman Morris , Kumar Sanjeev , Pasternak Stephen , Pollock Bruce G. , Rajji Tarek K. , Tang‐Wai David F. , Abrahao Agessandro , Turnbull John , Zinman Lorne , Casaubon Leanne , Dowlatshahi Dar , Hassan Ayman , Mandzia Jennifer , Sahlas Demetrios , Saposnik Gustavo , Grimes David , Marras Connie , Steeves Thomas , Masellis Mario , Farhan Sali M. K. , Bartha Robert , Symons Sean , Hegele Robert A. , Black Sandra E. , Ramirez Joel ,   ONDRI Investigators
Published: June 2023

AbstractINTRODUCTIONCerebral small vessel disease (SVD) is common in patients with cognitive impairment and neurodegenerative diseases such as Alzheimer's and Parkinson's. This study investigated the burden of magnetic resonance imaging (MRI)‐based markers of SVD in patients with neurodegenerative diseases as a function of rare genetic variant carrier status.METHODSThe Ontario Neurodegenerative Disease Research Initiative study included 520 participants, recruited from 14 tertiary care centers, diagnosed with various neurodegenerative diseases and determined the carrier status of rare non‐synonymous variants in five genes (ABCC6, COL4A1/COL4A2, NOTCH3/HTRA1).RESULTSNOTCH3/HTRA1 were found to significantly influence SVD neuroimaging outcomes; however, the mechanisms by which these variants contribute to disease progression or worsen clinical correlates are not yet understood.DISCUSSIONFurther studies are needed to develop genetic and imaging neurovascular markers to enhance our understanding of their potential contribution to neurodegenerative diseases.
Symmetry and Topology of the Topological Counterparts in Non‐Hermitian Systems
Authors: Li Jing‐Quan , Li Jia‐Jie , Qi Lu , Zhang Zhi‐Xu , Cao Ji , Cui Wen‐Xue , Zhang Shou , Wang Hong‐Fu 
Published: June 2023

AbstractThe symmetries and topological properties of the topological counterparts in 1D non‐Hermitian systems are investigated. It is found that, after applying the non‐unitary similarity transformation, the non‐unitary topological counterpart in real space exhibits completely different global symmetries except for the sublattice symmetry and reveals many brand new local symmetries. Due to the abundant symmetries of non‐unitary topological counterparts, it is also found that the unique overlapping projections about the unit sphere vector representing the eigenstates appear in the nontrivial regions, and the triviality of the point‐gap topology of non‐unitary topological counterpart completely eliminate the intrinsic skin effect in non‐Hermitian systems. It is also shown that the unitary topological counterpart never arises any changes for the original symmetries and topological structures even in real space. Unitary topological counterparts are further summarized about the two‐band Bloch Hamiltonian, which can expand the definition of non‐Bloch winding number. Furthermore, it is demonstrated theoretically that the Bloch Hamiltonian would still hold time‐reversal symmetry, abnormal particle‐hole symmetry, and sublattice symmetry even suffering from the non‐unitary transformation. This work provides a new way to understand the roles of symmetry and topology in non‐Hermitian systems from the perspective of topological counterparts.
Significant applications of an affordable and simply prepared portable carbon‐based potentiometric sensor for the highly selective and sensitive determination of Cu(II) ions released from food contact materials
Authors: A. Mohammed Youssef , Abbas Ashraf A. , El Badry Mohamed Marwa 
Published: June 2023

Herein, an affordable, sensitive, and accurate potentiometric method based on a modified carbon paste electrode (MCPE) incorporating 2,2′‐(ethane‐1,2‐diylbis (sulfanediyl)) dianiline, as a selective ionophore, has been introduced for the determination of Cu(II) ions concentration in different real samples. The developed MCPE has a high sensitivity for Cu(II) ions within a wide concentration range from 1.0 × 10−7 to 5.0 × 10−3 mol L−1, a low limit of detection value (LOD) of 5.6 × 10−8 mol L−1, and a Nernstian slope of 29.4 ± 0.28 mV/decade. Furthermore, the developed sensor has a rapid response time (24 s), can work successfully in a wide pH range of 4.5–7.0, and is highly selective to Cu(II) ions over many other cations. The proposed sensor's external surface was scrutinized by the scanning electron microscope (SEM) and energy dispersive X‐ray analysis (EDX). Finally, the optimized MCPE was successfully applied for the determination of Cu(II) ions content in different soil samples. Moreover, our MCPE is the first potentiometric sensor applied for the monitoring of the release of Cu(II) ions from one of the commercially available unlined copperware after exposure to food simulants under different conditions. The results were in agreement with those of the inductively coupled plasma (ICP) technique.
Distribution and habitat use of a rare native crayfish: Implications for conserving Data Deficient species
Authors: Hays Hayden C. , Pease Allison A. , Fleming Paul , Barnes Matthew A. 
Published: June 2023

Abstract

Few observations exist for the Kisatchie painted crayfish (Faxonius maletae), and little is known about its distribution, habitat use, or population structure. The lack of basic ecological data has led to a ‘Data Deficient’ designation, a category of conservation concern that is often overlooked for management actions. This work provides updated data and practical management suggestions for similarly Data Deficient species.
Comprehensive (i.e. beyond known collection sites) crayfish surveys paired with habitat assessments across north‐east Texas were conducted. Among 74 survey sites in 10 counties within and adjacent to the known range for F. maletae, eight total crayfish species were encountered within 35 of these sites (47.3% of the total). Thirteen F. maletae individuals were collected across seven sites (9.5%). Notably, two individuals were found where the species had not been previously observed.
Stepwise multiple logistic regression indicated that conductivity and availability of exposed root masses were positively related to F. maletae presence, although neither factor was statistically significant on its own. Neither nonmetric multidimensional scaling nor canonical correspondence analysis identified patterns between F. maletae presence and the presence of other crayfish species.
Overall, F. maletae is geographically rare and occurs in exceptionally low abundance, challenging the ability to understand drivers of its distribution. However, given the depth of this survey, we can confidently say that F. maletae is no longer Data Deficient; rather, there is compelling evidence that it has a limited range and small population size.
The Data Deficient versus rarity debate has wide‐reaching impacts on the conservation of aquatic taxa; species that are Data Deficient require heightened research focus in general, whereas rare organisms require targeted management to protect specific habitats. Furthermore, we suggest that future management efforts should focus on maintaining current populations through active monitoring to inform the potential habitat suitability of new areas for protection.
Experimentelle Untersuchungen zum Einfluss des statischen Systems und der Belastungsart auf die Querkrafttragfähigkeit von Balken mit geringer Querkraftbewehrung
Authors: Tue Nguyen Viet , Betschoga Christoph , Tung Nguyen Duc 
Published: June 2023

AbstractDer vorliegende Aufsatz berichtet über experimentelle Untersuchungen zum Querkraftverhalten von Balken mit geringer Querkraftbewehrung unterschiedlicher statischer Systeme und Belastungen. Insgesamt wurden vier Einfeldbalken unter Einzellasten, zehn Kragbalken und drei simulierte Durchlaufbalken unter Gleichstreckenlasten getestet. Der Querkraftbewehrungsgrad wurde zwischen dem 0‐ (querkraftunbewehrt) und 2,0‐Fachen der Mindestquerkraftbewehrung nach EC2 variiert. Die Versuchsergebnisse zeigen einen erheblichen Einfluss des statischen Systems und der Belastungsart auf das Rissbild und die Traglast der untersuchten Balken. Während eine Querkraftbewehrung unterhalb der Mindestquerkraftbewehrung kaum Einfluss auf die Querkrafttragfähigkeit von Einfeldbalken unter Einzellasten hat, führt eine derart geringe Querkraftbewehrung bereits zu einer deutlichen Steigerung der Querkrafttragfähigkeit bei Balken unter Gleichstreckenlast. Im Vergleich zu Balken ohne Querkraftbewehrung bleibt das Rissbild jedoch unverändert, sodass das Versagen weiterhin durch einen einzelnen kritischen Schubriss gekennzeichnet wird. Ein Vergleich mit derzeit gültigen Berechnungs‐ bzw. Normvorschriften zeigt mögliche Verbesserungspotenziale in den angewendeten Modellen.
A natural heme deficiency exists in biology that allows nitric oxide to control heme protein functions by regulating cellular heme distribution
Authors: Stuehr Dennis J. , Biswas Pranjal , Dai Yue , Ghosh Arnab , Islam Sidra , Jayaram Dhanya Thamaraparambil 
Published: June 2023

AbstractA natural heme deficiency that exists in cells outside of the circulation broadly compromises the heme contents and functions of heme proteins in cells and tissues. Recently, we found that the signaling molecule, nitric oxide (NO), can trigger or repress the deployment of intracellular heme in a concentration‐dependent hormetic manner. This uncovers a new role for NO and sets the stage for it to shape numerous biological processes by controlling heme deployment and consequent heme protein functions in biology.
Surprisingly unsustainable: How and when hindsight biases shape consumer evaluations of unsustainable and sustainable products
Authors: Geissmar Julien , Niemand Thomas , Kraus Sascha 
Published: June 2023

AbstractSustainability as a vital purchase criterion in sustainable consumption contexts is often biased by misguided information. In this context, we investigate the hindsight bias, i.e., consumers think in hindsight that they knew what would happen all along, may lead consumers to think they evaluated attributes of unsustainable or sustainable products correctly all the time while they did not, devaluating downstream marketing variables. This paper experimentally investigates the hindsight bias by manipulating information about a products' sustainability. We focus on two perspectives about hindsight biases, namely, marketing and psychology, to explore the interaction of surprise and sustainability. In a set of two online studies (Study 1: n = 300; Study 2: n = 461), we found a group‐based hindsight bias for high‐involvement, unsustainable products (Study 1) and individual hindsight biases for low‐involvement, unsustainable and sustainable products (Study 2). Contributing to both, mostly separately researched perspectives, we conclude that neither is predominantly correct. Instead, both perspectives jointly determine why consumers evaluate products differently. Confronted with surprising, sustainable information about unsustainable products causes a hindsight bias that increases purchase intention and word of mouth. In contrast, surprising, unsustainable information about sustainable products show opposed effects. Implications for marketing practice show when product information can unintentionally cause greenwashing and how product information should be communicated to underline a product's sustainability.
Circular economy practices and environmental performance: Analysing the role of big data analytics capability and responsible research and innovation
Authors: Sahoo Saumyaranjan , Upadhyay Arvind , Kumar Anil 
Published: June 2023

AbstractThis study employs dynamic capability view theory to comprehend the interplay between big data analytics capability (BDAC), responsible research and innovation (RRI) and circular economy practices (CEPs) as an execution strategy for improving environmental performance. The study uses partial least square structural equation modelling to analyse primary survey data collected from 326 manufacturers. The results indicate that BDAC, RRI and CEPs favourably affect environmental performance. Notably, RRI emerges as the most influential factor among the three. Furthermore, the findings suggest that implementing CEPs serves as a partial mediator for the influence of BDAC and RRI on environmental performance. Surprisingly, the study finds that the moderating impact of resource commitment is not statistically significant in any of the three pairwise interactions involving BDAC, RRI and CEPs with respect to environmental performance. The results have various intriguing implications for how manufacturers can enhance their circular economy strategies to achieve better environmental performance, representing a noteworthy contribution to the foundational theory of the dynamic capability view. Finally, these findings also provide valuable insights to managers, enabling a deeper understanding of the determinants that contribute to deploying CEPs and improving environmental performance within a manufacturing setting.
Factors predictive of clinical outcome in advanced hepatocellular carcinoma patients receiving ramucirumab treatment: A real‐world experience
Authors: Lin Po‐Ting , Hung Min‐Hua , Shao Shih‐Chieh , Chen Hui‐Yu , Chan Yuk‐Ying , Chang Kai‐Cheng , Lin Shi‐Ming , Ou Huang‐Tz 
Published: June 2023

AbstractPurposeThe aim of this study was to investigate the factors predictive of clinical outcome in advanced hepatocellular carcinoma patients receiving ramucirumab treatment.MethodsWe conducted a retrospective study using a multi‐institutional electronic medical records database in Taiwan. We included advanced HCC patients newly receiving ramucirumab as second‐line or beyond systemic therapy between January 2016 and February 2022. The clinical outcomes were median progression‐free survival (PFS) based on the modified Response Evaluation Criteria in Solid Tumors (mRECIST), overall survival (OS) and adverse events. We applied Kaplan–Meier methods to estimate median PFS and OS. Uni‐variable and multi‐variable Cox regression models were applied to identify the prognostic factors.ResultsWe included 39 ramucirumab naive users with a median age of 65.5 (IQR: 57.0–71.0) years and treatment time of 5.0 (3.0–7.0) cycles, of whom 82.1% were male and 84.6% were Barcelona Clinic Liver Cancer (BCLC) stage C. After median follow‐up time of 6.0 months, 33.3% of patients' AFP level had decreased more than 20% within 12 weeks. The median PFS and OS were 4.1 months and non‐reach, respectively. Moreover, tumor burden beyond the up‐to‐11 criteria (HR: 2.95, 95% CI: 1.04–8.38) and a decrease in estimated glomerular filtration rate of more than 10% within 12 weeks (HR: 0.31, 0.11–0.88) were significantly related to PFS in the multi‐variable analysis. No patient discontinued ramucirumab during the treatment on account of side effects.ConclusionRamucirumab was an effective treatment option with good AFP response for advanced HCC patients in real‐world experience. Tumor burden beyond the up‐to‐11 criteria and a decrease in estimated glomerular filtration rate were independent predictive factors for progression‐free survival.
One‐pot Synthesis of Bulk NiMoS Catalysts: Influence of pH and Addition of Pluronic®P123. Hydrodesulfurization of Model Sulfur Molecules Representative of FCC Gasoline
Authors: Courthéoux Laurence , Hétier Valentin , Carvalho Alexandre , Rousseau Julie , Lacroix‐Desmazes Patrick , Girard Etienne , Uzio Denis , Brunet Sylvette , Pradel Annie 
Published: June 2023

AbstractThe worldwide continual reinforcement of regulations for the production of cleaner fuels along with the larger demand for energy urge us to develop hydrotreatment sulfide catalysts exhibiting higher activity in hydrodesulfurization reactions and explore innovative synthesis strategies. In this work, a novel one‐pot synthesis method of unsupported NiMoS catalysts in water at ambient pressure and moderate temperature is described. The reaction conditions including pH variations and addition of a copolymer structuring agent were thoroughly investigated. Catalytic performances of the prepared bulk NiMoS catalysts were measured for the hydrodesulfurization of two model sulfur molecules, representative of FCC gasoline. Catalysts prepared at pH 7 without or with polymer exhibited roughly similar activity, resulting however from different characteristics favorable for catalyst efficiency probably compensating one another, i. e. a very high promotion rate for the first one and smaller particles along with larger specific surface area for the second.
Three‐Dimensional, Molecule‐Sensitive Mapping of Structured Falling Liquid Films Using Raman Scanning
Authors: Nachtmann Marcel , Feger Daniel , Wühler Felix , Scholl Stephan , Rädle Matthias 
Published: June 2023

AbstractA method for molecule‐sensitive, non‐contact and marker‐free 3D mapping of vertical falling liquid films using Raman spectroscopy is presented. Technical liquid films are common in many applications in the chemical industry such as columns, evaporators, dryers and absorbers/desorbers. Measurements of an aqueous sodium sulfate film on a plain surface with a small pyramid attached to it, as well as a pillow plate are presented using a 3D surface plot. Suppressing surface gloss as well as other optical reflections from the metallic backplates is realized by using only inelastic light scattering and mathematical background correction. The results show that liquid mapping with Raman spectroscopy is possible and 3D maps can be created from different structured surfaces.
Efficacy and safety of pralsetinib in patients with advanced RET fusion‐positive non–small cell lung cancer
Authors: Zhou Qing , Zhao Jun , Chang Jianhua , Wang Huijie , Fan Yun , Wang Ke , Wu Gang , Nian Weiqi , Sun Yuping , Sun Meili , Wang Xiangcai , Shi Huaqiu , Zheng Xiangqian , Yao Sheng , Qin Mengmeng , Shen Zhenwei , Yang Jason , Wu Yi‐Long 
Published: June 2023

AbstractBackgroundPralsetinib is a potent, selective RET inhibitor targeting oncogenic RET alterations. As part of the global, phase 1/2 ARROW trial (NCT03037385), the efficacy and safety of pralsetinib in Chinese patients with advanced RET fusion‐positive non–small cell lung cancer (NSCLC) were evaluated.MethodsAdult patients with advanced, RET fusion–positive NSCLC with or without prior platinum‐based chemotherapy were enrolled into two cohorts receiving 400‐mg once‐daily oral pralsetinib. Primary end points were objective response rates assessed by blinded independent central review and safety.ResultsOf 68 patients enrolled, 37 had received prior platinum‐based chemotherapy (48.6% with ≥3 prior systemic regimens) and 31 were treatment‐naïve. As of March 4, 2022 (data cutoff), of the patients with measurable lesions at baseline, a confirmed objective response was observed in 22 (66.7%; 95% confidence interval [CI], 48.2–82.0) of 33 pretreated patients, including 1 (3.0%) complete response and 21 (63.6%) partial responses; and in 25 (83.3%; 95% CI, 65.3–94.4) of 30 treatment‐naïve patients, including two (6.7%) complete responses and 23 (76.7%) partial responses. Median progression‐free survival was 11.7 months (95% CI, 8.7–not estimable) in pretreated patients and 12.7 months (95% CI, 8.9–not estimable) in treatment‐naïve patients. The most common grade 3/4 treatment‐related adverse events in 68 patients were anemia (35.3%) and decreased neutrophil count (33.8%). Eight (11.8%) patients discontinued pralsetinib because of treatment‐related adverse events.ConclusionPralsetinib showed robust and durable clinical activity with a well‐tolerated safety profile in Chinese patients with RET fusion‐positive NSCLC.Clinical trial registration: NCT03037385.
Preparation of CuxSb/Ti Electrodes by Electrodeposition and their Sodium Storage Performance
Authors: Chen Gang , Li Mingqi 
Published: June 2023

AbstractTo explore a simple and green synthesis method for constructing high‐performance Sb‐based electrodes for sodium‐ion batteries, four CuxSb alloy films with different compositions are deposited on Ti substrates through constant current step technique using SbCl3 and CuCl2 ⋅ 2H2O as raw materials (referred to as CuxSb/Ti). Among them, the prepared Cu1.33Sb/Ti electrode exhibits the best comprehensive electrochemical performance. At a current density of 0.2 A g−1, the electrode has a first reversible capacity of 385.2 mAh g−1 with a coulombic efficiency of 76.7%. After 150 cycles, the reversible capacity remains at 343.5 mAh g−1 with a capacity retention of 89.2%. A stable discharge capacity of 290.5 mAh g−1 can be obtained at a current density of 2 A g−1. The excellent electrochemical performance is attributed to the introduction of inactive Cu, which alleviates the destruction of the volume variation during charging and discharging and improves the conductivity of the electrode. At the same time, CuTi alloy formed from Cu with Ti substrate enhances the bonding force between the alloy film and the substrate. This work provides a new approach for the preparation of Sb‐based alloy anodes for sodium‐ion batteries with low cost, high performance, and free of adhesives and conductive agents.
Rapid Colorimetric Detection of Heavy Metal Hg2+ in Cosmetics Based on Amrinone‐Modified AuNPs Sensor
Authors: Li Guona , Liu Lvcheng , Liu Xiaoying , Han Junshan , Hao Tingting , Wang Chucheng , Sun Jiawei , Du Hengfeng , Li Xing 
Published: June 2023

AbstractMercury is unacceptable as a whitening agent in cosmetics because it is highly toxic and much harmful to the digestive, respiratory, circulatory, and nervous systems of humans. Therefore, it is of fundamental and practical importance to detect whether the concentration of mercury in cosmetics meets national standards. In this work, a new way for the simple visual and rapid colorimetric detection of Hg2+ using gold nanoparticle (AuNPs) modified with amrinone (3‐amino‐5‐pyridin −4‐yl‐1H‐pyridin‐2‐one, ALN) is proposed and characterized by transmission electron microscopy (TEM), dynamic light scattering (DLS), UV‐vis, Fourier transform infrared (FTIR) and analyzed of Gaussian16w and Multiwfn simulations. The solution colors changed from wine‐red to gray‐blue with increasing Hg2+ concentration resulting from the agglomeration of AuNPs with favorable anti‐interference and selectivity. The limit of detection (LOD) is 0.8 μmol/L by the unaided eye, and 18.2 nmol/L by UV‐vis spectroscopy with the excellent linear relationship (R2=0.9935) in the range of 0.0∼6.0 μmol/L (Hg2+ concentration), showing that AuNPs modified with ALN can serve as the quantitative determination of Hg2+. After testing actual samples, it is found that the test method can be practically applied to the monitoring of heavy metal mercury in cosmetics.