bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perhaps charcoal remembers: A methodological approach to the interpretation of archaeological charcoal assemblages, with a focus on the study of socio-environmental relationships in central-western Argentina
Authors: Mafferra Luis Eduardo 
Published: March 2023

Abstract
This paper proposes a synthesis that allows articulating anthracological data with diverse contextual information: archaeological, historical, ethnographic, and environmental, as well as theoretical proposals on socio-environmental relationships. In particular, the north of Mendoza is analyzed in central-western Argentina during the period from 1200 to 100 years BP, which allows for comparing cases associated with the pre-Hispanic, colonial, and modern periods. For each of them, the existence of human groups with different ways of life integrated into specific environments is analyzed. To this end, for each case, the characterization of some interrelated categories is explored: 1) Modes of dwelling: settlement, mobility, production modes, or demand for firewood; 2) socio-environmental relationship frameworks: different ways of conceiving and relating to the environment; 3) Archaeological record and firewood use: analysis of charcoal samples according to their archaeological context and class indices of richness, diversity, and abundance; particularities of the plants found based on their uses, origin, habit, or association with domestication processes, among others; 4) Landscape shaping: observation of the environmental dynamics in which human groups are integrated in relation to the first three categories. The results allow for raising problems and questions that enrich the social interpretation of the anthracological record. In sum, the work addresses a methodological approach that explores the potential of this materiality for the study of socio-environmental relationships.
Systematic Mendelian randomization study of the effect of gut microbiome and plasma metabolome on severe COVID-19
Authors: Yan Han , Zhao Si , Huang Han-Xue , Xie Pan , Cai Xin-He , Qu Yun-Dan , Zhang Wei , Luo Jian-Quan , Zhang Longbo , Li Xi 
Published: March 2023

AbstractBackground COVID-19 could develop severe respiratory symptoms in certain infected patients, especially in the patients with immune disorders. Gut microbiome and plasma metabolome act important immunological modulators in the human body and could contribute to the immune responses impacting the progression of COVID-19. Methods Based on two-sample Mendelian randomization framework, the causal effects of 131 microbiota in genus or species level and 452 plasma metabolites on severe COVID-19 are estimated. Single nucleotide polymorphisms (SNPs) strongly associated with the abundance of intestinal bacteria in gut and the concentration of metabolites in plasma have been utilized as the instrument variables to infer whether they are causal factors of severe COVID-19. In addition, mediation analysis is conducted to find the potential link between the microbiota and metabolite which identified by polygenic Mendelian randomization analysis, while colocalization analysis has been performed to validate the causal relationships which identified bycis-Mendelian randomization analysis. Results Mendelian randomization support 13 microbiota and 53 metabolites, which are significantly causal association with severe COVID-19. Mediation analysis find 11 mediated relations, such as myo-inositol, 2-stearoylglycerophosphocholine and alpha-glutamyltyrosine, which appeared to mediate the association ofHowardellaandRuminiclostridium 6with severe COVID-19 respectively, whileButyrivibrioandRuminococcus gnavusappeared to mediate the association of myo-inositol and N-acetylalanine respectively.Ruminococcus torquesabundance was colocalized with severe COVID-19 (PP.H4 = 0.77) and the colon expression of permeability related protein RASIP1 (PP.H4 = 0.95). Conclusions Our study results highlight the causal relationships of gut microbiome and plasma metabolome for severe COVID-19, which have the promise to be served as clinical biomarkers for risk stratification and prognostication, and novel basis to unravel the pathophysiological mechanisms of severe COVID-19.
Heterogeneous Regularization for Fast Rendering using Deep Spike Neural Network
Authors: CONSTANTIN Joseph , CONSTANTIN Ibtissam , Dornaika Fadi , Hoang Vinh Truong 
Published: March 2023

Abstract
In real-time rendering, images are computed at a very high speed to make them look like the real scenes. Speed and interactivity play an important role in real-time rendering. However, computing indirect lighting in real time is a major challenge because it is very computationally intensive. To be used in video movies, the rendering program must run very fast and the video engine must operate at a constant frame rate. The images must be noise-free and the animations must remain stable without temporal artifacts. Global lighting in videos is still a real challenge. The rendering program must calculate the entire light exchange between the surfaces of a virtual 3D scene. Offline techniques are capable of rendering photo-realistic images, but none of these algorithms is capable of generating images in real time with a high number of frames per second. In this work, a Deep Spiking Neural Network with Heterogeneous Regularization learning technique is proposed with the aim of building a more biologically plausible network to evaluate the amount of noise and find a stopping criterion for fast realistic illumination. The idea is to improve learning performance by extracting the most relevant features with a deep spiking neural network to achieve high rendering quality. We used a new objective function composed from a supervised term and an unsupervised term. The supervised term enforces the fitting term between the predicted labels and the known labels. The unsupervised term imposes the smoothness of the predicted labels. The experiments was performed on scenes with global illumination containing different image distortions. The proposed model is also compared with the human visual system and other state-of-the-art models. Results show better performance and advantages in terms of efficiency, an increasingly biologically plausible network, and ease of implementation in Neuromorphic hardware.
Integrative analysis of S100A2 in pan-cancer and verification in glioma
Authors: Liu Xiang , Zhou Qiang , Chen Erhua , Yang Yue , Hu Nan 
Published: March 2023

Abstract
S100A2 (S100 Calcium Binding Protein A2) is one of the 25 members of S100 protein family. S100A2 was involved with suppress tumor invasion and cancer progression. However, there was no pan-cancer analysis of S100A2 reported recently. This study sought to identify the effect of A100A2 on the immunological role and prognosis in pan-cancer. The expression of S100A2 was analyzed in 33 different cancers by using TCGA and GTEx database. The analysis of S100A2 gene expression was performed using the glioma samples from the cancer genome atlas (TCGA)-lower grade glioma and glioblastoma (GBMLGG) cohort. We assessed the association of S100A2 expression with molecular and immune subtypes in pan cancer. Then, we explored the S100A2-bingding proteins, the biological and molecular functions of S100A2, diagnosis and prognosis of S100A2 in pan cancer. Subsequently, based on the pan cancer analysis, we narrowed the focus to the relationship of S100A2 expression with clinical characteristics, overall survival (OS), disease-specific survival (DSS), and progression- free interval (PFI) in the GBMLGG. In addition, we analyzed the correlation of S100A2 and immune cells in pan cancer from the TIMER2 database. S100A2 was differently expressed in pan cancer, and it was associated with molecular subtypes and immune subtypes in various cancers. The infiltration levels of CD8+ T cells, CD4+ T cells were associated with S100A2 expression. Pan cancer cox regression analysis showed that S100A2 high expression can cause a poor prognosis. Further investigation showed that the higher expression S100A2 had a worse OS, DSS and PFI in some clinical subgroups of GBMLGG. Our results showed that S100A2 expression was linked to WHO grade, IDH status, gender, age, and histological type of GBMLGG. We also found that the first 50 important genes that positively correlated with S100A2 expression in GBMLGG. In conclusion, our research provides a molecular biomarker for the therapy in GBMLGG.
Plasmon-Stimulated Synaptic Transistor
Authors: Song Zehao , Wind Lukas , Sistani Masiar , Schwingshandl Fabian , Lugstein Alois 
Published: March 2023

Abstract
With the emerging transition from programmed to learning computing, traditional electronic ICs are unlikely to be able to match the massive perceptual data that will need to be processed in real-time. Neuromorphic engineering may surmount the von Neumann bottleneck by creating high-performance hardware for distributed and parallel processing with low power consumption. Nowadays, most of high-efficiency neuromorphic hardware is based on artificial synapsis and neuronal devices, utilizingelectrical or optical platforms and thus correspondingly limited in terms of bandwidth or footprint, respectively. In this work, we introduce a plasmon-stimulated synaptic transistor concept that may combine the high bandwidth of a photonic network with the compactness of electronic circuits. The actual synaptic characteristic, including excitatory postsynaptic current and paired-pulse facilitation, is achieved utilizing charge trapping effects to control the conductivity of a monolithic Al-Ge-Al Schottky barrier field-effect transistor. The population of traps is thereby controlled by hot electrons arising from the non-radiative decay of deliberately applied surface plasmon polariton spikes. The temporal dynamics of the trapping process and thus the plasticity of the synaptic transistor can be set by the geometry and operation mode of the synaptic transistor as well as the intensity and duration of the plasmon spikes.
Compliance to Glycemic Control and Diabetes Dietary Practice among Type 2 Diabetic Patients: Institution based cross-sectional study
Authors: Hailu Dejene , Zegeye Menen , Desta Derese Tamiru , Getachew Meheret Tena , GebreMichael Mignote 
Published: March 2023

Abstract
Objectives
Dietary control is regarded as one of the cornerstones of diabetes treatment. The lack of information on dietary habits of diabetes patients undersells the significance of these habits in the management of the condition. Therefore, this study examined the food habits and contributing factors of Type 2 diabetic patients in Hawassa City, Sidama Regional State, Ethiopia.
Results
Nearly forty-seven percent (46.8%) of the patients had poor knowledge about diabetes. More than half of the respondents (54.5%) were overweight and obese. The levels of dietary practice among 171 (44.2%) type 2 diabetic patients were poor. Very low monthly income [AOR = 4.87; 95% CI :(1.20-19.81], taking insulin regimen [AOR = 2.36; 95% CI :(1.13–4.91)], taking both insulin injection and oral medication [AOR = 11.26; 95% CI: (3.05–41.54)], not getting DM education in hospital [AOR = 2.72; 95% CI :( 1.08–6.85)], despondency [AOR = 3.71; 95% CI:(1.39–9.89), lack of support from family and friends about dietary plan [AOR = 5.64;95% CI (2.66,11.92)], unavailability of fruits and vegetables[AOR = 3.04;95% CI:(1.11–8.34)] were the factors significantly associated with the poor dietary practice.
The synergistic effect of EGCG and conditioned medium derived from WJ-MSCs on androgen receptor and apoptotic signaling pathway in prostate cancer LNCaP cells
Authors: Mohammadi Reihane , Fazeli Zahra , Daraei Azam , Asgari Katayoon 
Published: March 2023

AbstractProstate cancer (PCa) was known as the second most common cancer in men. Although there were several approaches to treat this disease, the cost and side effects of some approaches have encountered the patients with challenges. Therefore, the design of new therapy methods could be useful in the management of this disease. For this purpose, the synergic effect of Epigallocatechin gallate (EGCG) and conditioned medium derived from Wharton's jelly mesenchymal stem cells (WJ-MSCs) were studied on prostate cancer LNCaP cells. In this study, LNCaP cells were treated with different concentrations of EGCG and conditioned medium derived from WJ-MSCs (WJCM). The viability of treated cells was determined by using cell proliferation assay. Then, the expression of androgen receptor (AR and PSA) and apoptotic (BAX, CASP3 and CASP7) pathway genes were defined by Real time PCR. The analysis of the data indicated that the treatment with 400µM EGCG in combination with 50% WJCM (0% FBS) for 72 hours decreased expression of AR and PSA genes as well as the enhanced expression of BAX, CASP3 and CASP7 genes in the LNCaP cells (p<0.05). The obtained results suggested that the combination therapy of EGCG and WJCM had an anticancer effect on LNCaP cells through activation of apoptotic pathway and suppression of androgen receptor pathway.
Glial-Restricted Precursors stimulate endogenous cytogenesis and effectively recover emotional deficits in a model of cytogenesis ablation
Authors: Pinto Luísa , Macedo Joana , Araújo Bruna , Anjo Sandra , Silveira-Rosa Tiago , Patrício Patrícia , Teixeira Fábio , Manadas Bruno , Rodrigues Ana Joao , Lepore Angelo , Salgado António , Gomes Eduardo 
Published: March 2023

Abstract
Adult cytogenesis, the continuous generation of newly-born neurons (neurogenesis) and glial cells (gliogenesis) throughout life, is highly impaired in several neuropsychiatric disorders, such as Major Depressive Disorder (MDD), impacting negatively on cognitive and emotional domains. Despite playing a critical role in brain homeostasis, the importance of gliogenesis has been overlooked, both in healthy and diseased states. To examine the role of newly formed glia, we transplanted Glial Restricted Precursors (GRPs) into the adult hippocampal dentate gyrus (DG), or injected their secreted factors (secretome), into a previously validated transgenic GFAP-tk rat line, in which cytogenesis is transiently compromised. We explored the long-term effects of both treatments on physiological and behavioral outcomes. Grafted GRPs reversed anxiety-like and depressive-like deficits, while the secretome promoted recovery of only anxiety-like behavior. Furthermore, GRPs elicited a recovery of neurogenic and gliogenic levels in the ventral DG, highlighting the unique involvement of these cells in the regulation of brain cytogenesis. Both GRPs and their secretome induced significant alterations in the DG proteome, directly influencing proteins and pathways related to cytogenesis, regulation of neural plasticity and neuronal development. With this work, we demonstrate a valuable and specific contribution of glial progenitors to normalizing gliogenic levels, rescueing neurogenesis and, importantly, promoting recovery of emotional deficits characteristic of disorders such as MDD.
Towards Efficient Structured-grid Triangular Solver on Sunway Many-core Processors
Authors: Li Jianjiang , Liang Jiabi , Xue Wei , Hu Zhengding , Li Lin , Shi Jinliang 
Published: March 2023

Abstract

The sparse triangular solver (SpTRSV) is mostly used for scientific and engineering applications. The structured-grid triangular solver of regular dependencies (STRSV) is a special kind of SpTRSV. Some general SpTRSVs that disregards the regularity of STRSV are unsuitable for STRSV. This paper proposes an efficient parallel algorithm for STRSV on the SW26010 (swStructTRSV). The algorithm makes full use of the fine-grained and low latency communication characteristics of the SW26010 to reduce the waiting time for synchronization, maximizes the regularity of access to improve memory access bandwidth, and achieves overlap between memory access and computation simultaneously. Moreover, the idea of the algorithm can be extended to incomplete LU factorization (ILU factorization) because of consistent dependencies. The experimental results on 1 core group of SW26010 show that swStructTRSV can achieve an average speedup of 30.56 over the sequential version. swStructTRSV on SW26010 achieves solving speedups of 2.2 and 6.3 over the fast STRSV (fSpTRSV) previously implemented on SW26010 and MKL on Intel Xeon Gold 6132, respectively. swStructTRSV significantly outperforms cuSparse on NVIDIA TITAN RTX in terms of overall execution time.
Stabilizing Cobalt-Free Cathodes with Lithium-Stoichiometry Control for Sustainable Lithium-ion Batteries
Authors: Chen Ke , Barai Pallab , Kahvecioglu Ozge , Pupek Krzysztof , Ge Mingyuan , Ma Lu , Ehrlich Steven , Zhong Hui , Sriniva Venkat , Bai Jianming , Wang Feng 
Published: March 2023

Abstract
Lithium-ion batteries are essential to decarbonizing transportation and power grids, but their reliance on high-cost earth-scarce cobalt in nickel-manganese-cobalt (NMC) based cathodes raises significant supply chain and sustainability concerns. Despite numerous attempts to address these issues, eliminating Co has remained elusive, yet to be commercially realized because doing so detrimentally affects the layering and cycling stability of NMC cathodes. We report here an alternative solution using Co free high-Ni Li1 xNi0.95Mn0.05O2 (NM9505) with a Li-deficient composite structure that outperforms the stoichiometric layer-structured counterparts. Through correlated synchrotron X-ray characterization and multiscale modeling, we show that Li-deficiency plays a predominant role in hindering crystallization and interparticle fusion during calcination, resulting in intergrown rocksalt and layered phases within the composite. As such, the anisotropic lattice expansion and contraction is suppressed in Li-deficient NM9505 upon cycling, offering 90% first-cycle Coulombic efficiency, 90% capacity retention, and close-to-zero voltage fade for 100 cycles up to 4.4 V. Our findings represent an important step forward in addressing the critical Co-reliance issues, and offer new opportunities for designing high-performing Co-free cathodes for sustainable Li-ion batteries.
Anemia is associated with low bone mass in patients with non-alcoholic fatty liver disease
Authors: Yang Hong , Liao Zhongjian , Zhong Junyuan , Chen Xiao 
Published: March 2023

AbstractBackground Nonalcoholic fatty liver disease (NAFLD) is linked to osteoporosis and anemia. Anemia may be also a risk factor of osteoporosis. However, the association between anemia and bone health in patients with NAFLD has not been well clarified. In this study we showed the association between anemia and bone health in patients with NAFLD. Methods A total of 277 subjects (172 women and 105 men) with NAFLD were included in this study. Bone mineral density (BMD) was measured in L1-L3 veterbral body by computed tomography. Cortical thickness (mm) at the L3 veterbral body was also determined. Hemoglobin (Hgb) was determined in an automatic blood cell counter. Anemia was defined based on Hgb level (< 130 g/L in men and < 120 g/L in women). Results The age of patients with anemia was older than that without anemia. Correlation analysis further displayed that BMD was associated with Hb levels (r = 0.21, p < 0.01). The BMD and cortical thickness of men that had anemia was lower than that with normal Hgb (p < 0.05). The prevalence of osteoporosis in men with anemia was higher than that had normal Hgb (28.6%vs10.7%, p < 0.05). Multivariable analysis showed that anemia was an independent risk factor for osteoporosis in men (OR = 2.94, 95%CI: 1.14–15.60). No association was found between anemia and osteoporosis in women. Conclusion Anemia is associated with risk of osteoporosis in men with NAFLD, but not in women. Treatment of anemia may be helpful for bone health in male patients with NAFLD.
Cost-effectiveness and ecological performance of direct seeding to compose arrangements in biodiverse agroforestry systems
Authors: Lobtchenko J. C. P. , Fernandes S.S.L , Santos M. L.B.M. , Pereira J. G. , Padovan M. P. , Pereira Z. V. 
Published: March 2023

Abstract

Deforestation of primary vegetation and degradation of pastures in Brazil has presented alarming numbers in recent years, which demonstrates the emerging need for environmental recovery strategies such as agroforestry systems (SAFs). Thus, the objective was to adopt a low cost technique such as direct sowing to compose spatial arrangements in SAFs in consortium with different agricultural crops and fertilizers, as well as to evaluate the cost-effectiveness. In the experiment, 23 native species from adjacent fragments were used. The treatments were formed by combining 2 sowing densities (5 and 10), 2 fertilizers (bovine manure and poultry litter), and 2 agricultural crops (watermelon and pumpkin). The seeds were arranged in a planting furrow measuring 2m in length, 10 cm in width and 5 cm in depth, spaced 2m apart and 2m between plots. Each treatment consisted of three repeat, and each repeat with 2 planting furrows. The use of direct seeding is a promising technique to increase species diversity in the composition of spatial arrangements of SAFs, especially if combined with organic fertilization and cultivation of agricultural crops, which has proven to be a profitable alternative to reduce restoration costs, can be completely amortized in a second cycle of cultivars, because until the establishment of the tree canopy of native species, the cultivation of agricultural crops can be a source of income to the farmer and ensure their food security.
Individuals with higher trait self-esteem prefer to use reappraisal, but not suppression: Evidence from functional connectivity analyses
Authors: Chen Yang , Li Dan , Yin Huazhan 
Published: March 2023

Abstract

Individual differences in the regulation of emotion are associated with trait self-esteem (TSE). However, how TSE is linked with emotion regulation at the neural level is still poorly understood. Accordingly, we adopted the resting-state functional connectivity (rsFC) analysis to identify the neural bases linking TSE with emotion regulation. 234 young adults (44.9% females,Mage= 21.36) were guided to undergo the MRI scans and then complete the Rosenberg Self-Esteem Scale and the Emotion Regulation Questionnaire formed by two dimensions: cognitive reappraisal and expressive suppression. Results found that TSE mediated the relationships between the precuneus functional connectivity and different emotion regulation strategies. Specifically, rsFC analysis showed that TSE was positively correlated with rsFC, including right precuneus (rPrcu)-left superior frontal gyrus (lSFG) and left precuneus cortex (lPrcu)-left superior temporal gyrus (lSTG). Further mediation analysis indicated a mediated role of TSE in the link between the two connectivity and cognitive reappraisal. In addition, TSE was positively correlated with rsFC rPrcu-right lateral occipital cortex (rLOC). Further mediation analysis indicated a mediated role of TSE in the link between rPrcu-rLOC and expressive suppression. Overall, we reveal the neurofunctional correlates why people with higher TSE prefer to use cognitive reappraisal rather than expressive suppression.