bluuebunny/crossref_metadata_2025_split huggingface dataset:
Engagement with arts and culture activities in the Danish general population: Longitudinal associations with new onset or persistent depression and mental wellbeing
Authors: Santini Ziggi Ivan , Thygesen Lau Caspar , Krokstad Steinar , Bonde Lars Ole , Donovan Robert J. , Koushede Vibeke , Jensen Anita , Koyanagi Ai , Ekholm Ola 
Published: March 2023

AbstractObjectivesInternational literature suggests that arts and culture activities may benefit mental health, however, such survey studies conducted in the Danish population are scarce. Further, studies have investigated the associated risk for incident depression, but not for persistent depression. The objective of the current prospective study was to assess associations of engagement in arts and culture activities with incident/persistent depression and also mental wellbeing among Danish adults in the general population.DesignObservational prospective study.MethodsData stem from a Danish nationally representative panel study of 5000 adults (aged 15+ years) conducted in 2019 and 2020, which was linked to Danish register data. An exposure variable was constructed for frequency of attending concerts, theatres, museums, and cinemas. Validated scales were used to assess the presence of depression (PHQ‐8) and levels of mental wellbeing (SWEMWBS). Binary logistic regression analyses were conducted to assess the risk of incident depression (among participants free of depression at baseline), as well as the risk of persistent depression (among participants with depression at baseline), while multinomial logistic regression was used to assess odds for moderate and high mental wellbeing (low as base outcome) while adjusting for baseline values.ResultIn terms of incident depression, quarterly engagement in arts and culture activities (compared to never) was associated with an OR of .43 (95%CI .23–.80), while 8 times or more was associated with an OR of .53 (.29–.97). In terms of persistent depression, quarterly engagement was associated with an OR of .30 (.10–.90), while 8 times per year or more was associated with an OR of .26 (.07–.92). Similar to the patterns for incident/persistent depression, associations with moderate mental wellbeing showed higher odds for quarterly engagement and 8 times per year or more. Quarterly engagement was also associated with higher odds for high mental wellbeing but did not reach statistical significance.ConclusionsThe results support the involvement of the cultural and creative sectors in health strategies. Mental health promotion initiatives as well as arts and culture sectors may encourage the general public to engage in arts and culture activities with frequencies of at least once per quarter.
1058. Bethencourtia palmensis (C.Sm.) Choisy, Jean IV de Béthencourt, and the genus Bethencourtia Choisy: Compositae, Senecioneae
Authors: Reyes‐Betancort J. Alfredo , Sánchez‐Pinto Lázaro , Francisco‐Ortega Javier 
Published: March 2023

SummaryBethencourtia Choisy (Compositae, Senecioneae) has three species and is dedicated to Jean IV de Béthencourt (1362—ca.1425/1426), who led the first successful military European expedition to conquer the Canary Islands. The botanical history of this Canary Island genus is reviewed, and its nomenclature is revisited. The generitype, Senecio palmensis C.Sm. = B. palmensis (C.Sm.) Choisy, is illustrated (t. 1058). The names S. palmensis and S. hermosae Pit. are lectotypified. Phylogenetic relationships, conservation status, systematics, phytochemistry, and ecogeographical patterns are discussed. A list of the herbarium specimens which have been studied is given.
Real‐world use of Control‐IQ™ technology automated insulin delivery in pregnancy: A case series with qualitative interviews
Authors: Wang Xinye Serena , Dunlop Amy D. , McKeen Julie A. , Feig Denice S. , Donovan Lois E. 
Published: March 2023

AbstractBackgroundMost commercially available automated insulin delivery (AID) systems are not approved for pregnancy use. Information regarding use of the Tandem t:slim X2 insulin pump with Control‐IQ™ technology in pregnancy is lacking.AimsThis case series aimed to explore glycaemic and qualitative experiences of four early adopters of Control‐IQ technology in pregnancy.MethodsParticipants used Control‐IQ technology in pregnancy and postpartum and consented to analysis of glycaemic data and semi‐structured interviews.ResultsCase 1 began Control‐IQ technology at 10 weeks gestation. Her pregnancy glucose time‐in‐range (3.5–7.8 mmol/L [63–140 mg/dL]) increased from 58.7% to 73.3% by third trimester. Cases 2–4 began using Control‐IQ technology 0–2 months preconception. Pregnancy time‐in‐range glucose increased from 73.4% to 78.7%, 78% to 83.6%, and 46.5% to 71.9% between first and third trimesters, respectively. A mid‐pregnancy decline in time‐in‐range glucose was observed in two of the four participants related to suboptimal pump setting adjustments and delays in sensor and infusion set replacement. No diabetic ketoacidosis or severe hypoglycaemia occurred. All participants reported reduced diabetes management burden and improved sleep with Control‐IQ technology use.ConclusionsEarly adopters of Control‐IQ technology safely used this system off‐label in pregnancy and reported reduced diabetes management burden and improved sleep. The largest glycaemic improvements were observed among those with the lowest pregnancy time‐in‐range glucose at the beginning of pregnancy. Participants with low pregnancy glucose time‐in‐range increased their time‐in‐range with Control‐IQ technology use and participants with high pregnancy glucose time‐in‐range maintained and increased their time‐in‐range with less diabetes management burden.
Head injuries caused by contact with teeth during sports and exercise activities in Japanese schools during the period 2012–2018
Authors: Kanemitsu Anna , Nakajima Kazunori , Tsutsui Arata , Sakaue Takahiro , Togo Shinji , Takeda Tomotaka , Fukuda Kenichi 
Published: March 2023

AbstractBackground/AimDuring sports activities, teeth‐related contact can cause injury to both ally and opponent players, which can lead to potential infections and aesthetic problems. However, the extent of such injuries remains unclear. This study aimed to clarify the frequency and situation of head injuries caused by teeth (HICBT) occurring under the supervision of schools in Japan.Material and MethodsHICBT records were extracted from the Japan Sport Council data on head injuries occurring reported during the 7‐year period from 2012 to 2018 under the supervision of schools in Japan.ResultsOf the total 463,527 head injury cases during the study period, 4495 cases (approximately 1%) were HICBT. Of the HICBT cases, 3650 (81.20%) were related to sports and athletic activity. Such injuries were reported to occur most often during basketball with a rate of 57.07% and 50.43%; soccer/futsal was the next most common sport with a rate of 13.38% and 24.01% in junior high school and high school students. Tag games were responsible for a similar number of HICBT cases at 22.73% and 39.03% in kindergartens and elementary school students.ConclusionsA total of 4495 cases of HICBT were identified, accounting for about 1% of all head injuries under the supervision of schools in Japan during the study period. This result reminds us that our teeth could be the weapon against the players during sports events. HICBTs occurring during basketball and soccer/futsal, in which mouthguards are not mandatory, were conspicuous among junior and senior high school students. Active use of mouthguards in various sports will protect players as well as their teammates and opponents. Sports dentists should encourage the revision of rules, such as mandating the use of mouthguards, in popular sports with a high incidence of HICBT, such as basketball and soccer/futsal.
Molecular 14C evidence for contrasting turnover and temperature sensitivity of soil organic matter components
Authors: Jia Juan , Liu Zongguang , Haghipour Negar , Wacker Lukas , Zhang Hailong , Sierra Carlos A. , Ma Tian , Wang Yiyun , Chen Litong , Luo Ao , Wang Zhiheng , He Jin‐Sheng , Zhao Meixun , Eglinton Timothy I. , Feng Xiaojuan 
Published: March 2023

AbstractClimate projection requires an accurate understanding for soil organic carbon (SOC) decomposition and its response to warming. An emergent view considers that environmental constraints rather than chemical structure alone control SOC turnover and its temperature sensitivity (i.e., Q10), but direct long‐term evidence is lacking. Here, using compound‐specific radiocarbon analysis of soil profiles along a 3300‐km grassland transect, we provide direct evidence for the rapid turnover of lignin‐derived phenols compared with slower‐cycling molecular components of SOC (i.e., long‐chain lipids and black carbon). Furthermore, in contrast to the slow‐cycling components whose turnover is strongly modulated by mineral association and exhibits low Q10, lignin turnover is mainly regulated by temperature and has a high Q10. Such contrasts resemble those between fast‐cycling (i.e., light) and mineral‐associated slow‐cycling fractions from globally distributed soils. Collectively, our results suggest that warming may greatly accelerate the decomposition of lignin, especially in soils with relatively weak mineral associations.
Bilevel Topic Model‐Based Multitask Learning for Constructed‐Responses Multidimensional Automated Scoring and Interpretation
Authors: Xiong Jiawei , Li Feiming 
Published: March 2023

AbstractMultidimensional scoring evaluates each constructed‐response answer from more than one rating dimension and/or trait such as lexicon, organization, and supporting ideas instead of only one holistic score, to help students distinguish between various dimensions of writing quality. In this work, we present a bilevel learning model for combining two objectives, the multidimensional automated scoring, and the students’ writing structure analysis and interpretation. The dual objectives are enabled by a supervised model, called Latent Dirichlet Allocation Multitask Learning (LDAMTL), integrating a topic model and a multitask learning model with an attention mechanism. Two empirical data sets were employed to indicate LDAMTL model performance. On one hand, results suggested that LDAMTL owns better scoring and QW‐κ values than two other competitor models, the supervised latent Dirichlet allocation, and Bidirectional Encoder Representations from Transformers at the 5% significance level. On the other hand, extracted topic structures revealed that students with a higher language score tended to employ more compelling words to support the argument in their answers. This study suggested that LDAMTL not only demonstrates the model performance by conjugating the underlying shared representation of each topic and learned representation from the neural networks but also helps understand students’ writing.
Human papilloma virus‐16‐specificCD8+ T‐cell expansions characterize different clinical forms of lichen planus and not lichen sclerosus et atrophicus
Authors: Viguier Manuelle , Pérals Corine , Poirier Béatrice , Battistella Maxime , Aubin François , Bachelez Hervé , Prétet Jean‐Luc , Gheit Tarik , Tommasino Massimo , Touzé Antoine , Gougeon Marie‐Lise , Fazilleau Nicolas 
Published: March 2023

AbstractLichen planus (LP) is a cutaneomucosal chronic inflammatory disease characterized by a CD8+cytotoxic T‐lymphocytes (CTL) infiltrate. In erosive oral LP, we found HPV16‐specific activated CTL in lesions, supporting a pathogenic contribution of HPV16. Here, we investigated whether a similar scenario occurs in other clinical forms of LP and in lichen sclerosus et atrophicus (LSA), another chronic disease also affecting the mucosa and/or the skin. Blood CTL from LP and LSA patients expressed significant higher levels of granzyme B, perforin and CD107a proteins than healthy donors. Expansions of TCRVß3+CTL, with presence of TCR clonotypes identical to those previously detected in erosive oral LP, were found both in blood and mucosal/skin lesions of LP, and not of LSA patients. These expansions were enriched with HPV16‐specific CD8+T‐cells as shown by their recognition of the E711‐20immunodominant epitope. In LSA patients, the peripheral repertoire of CTL was oligoclonal for TCRVß6+CTL. Finally, although patients with LP and LSA have developed antibodies against HPV16 capsid L1, antibodies against HPV16 E6 were only observed in patients with LP. Overall, our data collectively suggest an involvement of HPV16‐specific CTL in different clinical forms of LP, not only in erosive oral LP, while a different scenario operates in LSA.
Simulation research on knowledge flow in a collaborative innovation network
Authors: Su Yi , Jiang Xuesong 
Published: March 2023

AbstractThis study takes diffusion capacity, absorptive capacity, and relationship strength as the main influencing factors, constructs models of knowledge flow in small‐world networks and scale‐free networks, and uses numerical simulation to observe the flow characteristics of explicit knowledge and tacit knowledge in different networks. The knowledge of explicit flow in different networks exhibits the phenomenon of knowledge emergence, but this phenomenon is more obvious in a small‐world network. The flow of tacit knowledge in a small‐world network has a better effect. In a scale‐free network, the quantity and frequency of knowledge flow are significantly higher than those in a small‐world network. The reason for this phenomenon is the differences in the response, connection and structure of different networks. The quantity and frequency of the flow of explicit knowledge in the same network are significantly higher than those of tacit knowledge. The reason for this phenomenon is the different types of knowledge flow in different modes, with different levels of flow difficulty and flow sustainability. First, this study visually compares the differences in flow between the two types of knowledge. Second, flow models of the two types of knowledge are constructed, and the flow characteristics of the two types of knowledge in different networks are simulated. Finally, the reasons for the differences in flow between the two types of knowledge are explained by using loosely coupled theory.
PriMed: Private federated training and encrypted inference on medical images in healthcare
Authors: Gopalakrishnan Aparna , Kulkarni Narayan P. , Raghavendra Chethan B. , Manjappa Raghavendra , Honnavalli Prasad , Eswaran Sivaraman 
Published: March 2023

AbstractIn healthcare, patient information is a sparse critical asset considered as private data and is often protected by law. It is also the domain which is least explored in the field of Machine Learning. The main reason for this is to build efficient artificial intelligence (AI) based models for preliminary diagnosis of various diseases, it would require a large corpus of data which can be obtained by pooling in patient information from multiple sources. However, for these sources to agree to sharing their data across distributed systems for training algorithms and models, there has to be an assurance that there will be no disclosure of the personally identifiable information (PII) of the respective Data Owners. This paper proposes PriMed, an approach to build robust privacy preserving additions to convolutional neural networks (CNN) for training and performing inference on medical images without compromising privacy. Since privacy of the data is preserved, large amounts of data can be effectively accumulated to increase the accuracy and efficiency of AI models in the field of healthcare. This involves implementing a hybrid of privacy‐enhancing techniques like Federated Learning, Differential Privacy, and Homomorphic Encryption to provide a private and secure environment for learning through data.
Effect of kidney bean extract on phytohaemagglutinin activity, functional properties, and the estimated glycaemic index in‐vitro
Authors: AL‐Ansi Waleed , Wang Yunji , Fan Mingcong , Li Yan , Qian Haifeng , Wang Li 
Published: March 2023

SummaryThis study aimed to decrease the activity of phytohaemagglutinins and kidney bean α‐amylase activity in some selected stable foods. Kidney bean α‐amylase inhibitors may inhibit mammalian α‐amylase, reducing the estimated glycaemic index (eGI). The effect of temperature, pH and protease pretreatment on PHA activity in the crude extract was investigated. Besides, the inhibitory effect of kidney bean extract on α‐amylase activity and properties was assessed. Results showed that the PHA activity was decreased to 6.97% from the aqueous extract of kidney beans, while the α‐AI activity was retained by 85.89% by acid protease treatment. The extract's α‐amylase inhibitory activity remained at 87.37% following simulation in a gastric environment, whereas no effect was observed in a simulated intestinal environment. Adding 3% of the extract decreased the eGI of bread, rice, steamed bread, and steamed corn bread from 65.00, 71.65, 68.17, and 63.41 to 30.69, 39.51, 22.30, and 19.69, respectively. The processing method of crude kidney bean extract examined in this study has significant reference value for the development of kidney bean α‐amylase inhibitors and can enhance the intensive processing level and industrial development value of kidney beans worldwide. This discovery suggests that kidney bean extracts can be used to develop foods with a low GI.
What can stop the ‘pester power’? A longitudinal study on the impact of children's audiovisual media consumption on media‐motivated food purchase requests
Authors: Binder Alice , Matthes Jörg 
Published: March 2023

SummaryBackgroundIn modern audiovisual media, children are confronted with an endless stream of food advertising. Thus, companies can undermine parents' best efforts to feed their children healthy foods. Indeed, parents often describe that their children request specific foods depicted in media, most of which are high in fat, salt, and/or sugar.ObjectivesLongitudinal research on the factors influencing media‐motivated food purchase requests remains scarce.MethodsIn a panel study, pairing data of N = 529 children (6–11 years) and one of their parents (N = 529), we examined how children's individual factors (i.e., age and body mass index [BMI]), their audiovisual media consumption, and different parental mediation styles are associated with parents' perceptions of children's media‐motivated food purchase requests.ResultsWhile age was negatively related and children's BMI positively related to children's media‐motivated food purchase requests, we found no overall effect of children's audiovisual media consumption. Interestingly, talking with children about foods during or after viewing (i.e., conversation‐oriented communication about foods depicted in media) increased media‐motivated food purchase requests, most likely by fostering the cognitive availability of food products. Restrictive media mediation exerted a negative effect (i.e., reduced purchase requests).ConclusionsFindings suggest that restricting exposure to food advertising in the media may be more powerful in stopping the ‘pester power’ than previously thought. Thus, policy‐supporting restrictions on depicting unhealthy foods in media content targeted at children may be helpful.
Blockchain adoption and application in closed‐loop production under information asymmetry
Authors: Li Jian , Li Yongming , Lai Kin Keung 
Published: March 2023

AbstractAlthough the decentralization and traceability features of blockchain technology are crucial for fostering closed‐loop production, there are numerous obstacles and insufficient incentives for its implementation. This paper constructs the analysis framework of blockchain adoption and application in closed‐loop production, including four parts: blockchain adoption incentive contract, condition analysis of blockchain application, revenue analysis of blockchain application, and information screening analysis of blockchain application. It is found that the adoption incentive contract is an important driving force to promote manufacturer to apply blockchain technology, and the manufacturer needs to pay information rent to the consumer under information asymmetry. The manufacturer can obtain consumer traceability preference and realize information screening between the manufacturer and consumer. Consumer traceability preference for new products can better promote traceable information technology level and closed‐loop revenue. This research is of great significance in promoting sustainable closed‐loop production.
Mining the potential therapeutic targets for COVID‐19 infection in patients with severe burn injuries via bioinformatics analysis
Authors: Cai Xueyao , Deng Jing , Shi Wenjun , Cai Yuchen , Ma Zhengzheng 
Published: March 2023

AbstractThe Coronavirus Disease‐19 (COVID‐19) pandemic is posing a serious challenge to human health. Burn victims are susceptible to severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection leading to delayed recovery and even profound debilitation. Nevertheless, the molecular mechanisms underlying COVID‐19 and severe burn are yet to be elucidated. In our work, the differentially expressed genes (DEGs) were identified from GSE157852 and GSE19743, and the common DEGs between COVID‐19 and severe burn were extracted. Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), protein–protein interactions (PPI), gene coexpression network, and multifactor regulatory network analysis of hub genes were carried out. A total of 44 common DEGs were found between COVID‐19 and severe burn. Functional analyses indicated that the pathways of immune regulation and cytokine response participated collectively in the development of severe burn and progression of COVID‐19. Ten significant hub genes were identified, including MERTK, SIRPA, TLR3, ITGB1, DPP4, PTPRC, LY75, IFIT1, IL4R, and CD2. In addition, the gene coexpression network and regulatory network were constructed containing 42 microRNAs (miRNAs) and 2 transcription factors (TFs). Our study showed the shared pathogenic link between COVID‐19 and severe burn. The identified common genes and pivotal pathways pave a new road for future mechanistic researches in severe burn injuries complicated with COVID‐19.
Acellular fish skin for wound healing
Authors: Esmaeili Ali , Biazar Esmaeil , Ebrahimi Maryam , Heidari Keshel Saeed , Kheilnezhad Bahareh , Saeedi Landi Farzaneh 
Published: March 2023

AbstractFish skin grafting as a new skin substitute is currently being used in clinical applications. Acceleration of the wound healing, lack of disease transmission, and low cost of the production process can introduce fish skin as a potential alternative to other grafts. An appropriate decellularization process allows the design of 3D acellular scaffolds for skin regeneration without damaging the morphology and extracellular matrix content. Therefore, the role of decellularization processes is very important to maintain the properties of fish skin. In this review article, recent studies on various decellularization processes as well as biological, physical, and mechanical properties of fish skin and its applications with therapeutic effects in wound healing were investigated.