bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neoadjuvant PD-1 blockade combined with chemotherapy is not superior to neoadjuvant chemotherapy alone in resectable locally advanced esophageal carcinoma
Authors: Cheng Daoan , Zhao Weiqing , Chen Rui , Li Dong , Tang Shuxian , Fang Cheng , Ji Mei 
Published: February 2023

Abstract
Background
Neoadjuvant chemotherapy (nCT) or neoadjuvant chemoradiotherapy followed by surgery has been recommended as standard treatment in patients with locally advanced esophageal cancer (LAEC). But the risk of tumor recurrence still remained, and many patients refused or abandoned radiotherapy because of the intolerable adverse effects in China. Neoadjuvant immunochemotherapy (nICT) followed by surgery has become an emerging treatment in patients with esophageal cancer. There was still no consensus on whether nICT was superior to nCT alone in patients with esophageal cancer.

Methods
In this retrospective study, patients with resectable esophageal cancer who received surgery after nICT (n=26, 40%) or nCT alone (n=39, 60%) were included. The patients were classified as nICT or nCT arm. The primary endpoints were pathological tumor response (PTR) and event-free survival (EFS). The different clinic-pathological features were compared by the Kruskal-Wallis test for continuous variables and the Chi-square (χ2) test for categorical variables. Kaplan-Meier curves were used to estimate EFS from the date of treatment to recurrence or death. All tests were 2-sided with a significative P-value defined <.05.

Results
Three (11.5%) of the 26 patients achieved pathological complete remission (pCR) in the nICT group, and four (10.3%) of the 39 patients achieved pCR in the nCT group, respectively (P=1.000). Six (23.1%) of the 26 patients achieved major pathological response (MPR) in the nICT group, and 11 (28.2%) of the 39 patients achieved MPR in the nCT group, respectively (P=0.645). Downstaging was achieved in 13 (44.8%) patients in the nICT group and 16 (55.2%) patients in the nCT group, respectively (P=0.732). To verify the tumor regression grade (TRG) results, we compared them with MPR and pCR, which showed a significant dependency (P< 0.001). Patients who achieved downgrading showed better MPR and pCR rates (P<0.001 and P =0.010). There was no significant difference in EFS between the nICT and nCT groups (HR=1.011, 95% CI: 0.421–2.425, P = 0.981).

Conclusions
Neoadjuvant PD-1 blockade combined with chemotherapy was not superior to chemotherapy alone for patients with resectable locally advanced esophageal carcinoma. However, more studies with long-term follow-up were needed to confirm this result.
Public conformism with health regulation is crumbling as COVID-19 becomes a chronic threat: Repeated Cross-sectional Studies
Authors: Bodas Moran , Wine Leora , Peleg Kobi 
Published: February 2023

Abstract
Background
The purpose of this study is to analyze the long terms trends in public attitudes toward the COVID-19 pandemic and compliance with self-quarantine regulations.

Methods
Repeated cross-sectional studies looking into data collected from nationally representative samples (N = 2568) of the adult population in Israel at five points in time representing the five morbidity waves of the COVID-19 pandemic. This study examined public trust in Israeli health regulations, levels of public panic, feelings of personal worry, and compliance with health regulations, specifically self-quarantine.

Results
Public trust in health regulations in January 2022 is at an all-time low (25%) compared to the maximum value of nearly 75% measured in March 2020. While reported worry is steadily reducing, the perception of public panic is increasing. In earlier rounds, public compliance with self-quarantine was reported close to 100%; however, it has dropped to 38% by January 2022 when compensation is not assumed. Regression analysis suggests that trust is a major predictor of compliance with health regulations.

Conclusions
The “fifth wave” of the COVID-19 pandemic brought about an all-time low in public trust in health regulations. The Israeli public, normally a highly compliant one, is showing signs of crumbling conformity.
ScRNA-seq and ST-seq in liver research
Authors: He Jia , Deng Chengxiang , Krall Leonard , Shan Zhao 
Published: February 2023

AbstractSpatial transcriptomics, which combine gene expression data with spatial information, has quickly expanded in recent years. With application of this method in liver research, our knowledge about liver development, regeneration, and diseases have been greatly improved. While this field is moving forward, a variety of problems still need to be addressed, including sensitivity, limited capacity to obtain exact single-cell information, data processing methods, as well as others. Methods like single-cell RNA sequencing (scRNA-seq) are usually used together with spatial transcriptome sequencing (ST-seq) to clarify cell-specific gene expression. In this review, we explore how advances of scRNA-seq and ST-seq, especially ST-seq, will pave the way to new opportunities to investigate fundamental questions in liver research. Finally, we will discuss the strengths, limitations, and future perspectives of ST-seq in liver research.
Clinical outcomes in COVID-19 among patients with hypertension in the Philippine CORONA Study
Authors: Espiritu Adrian I. , Sucaldito Ma. Sergia Fatima P. , Ona Deborah Ignacia D. , Apor Almira Doreen Abigail O. , Sy Marie Charmaine C. , Anlacan Veeda Michelle M. , Jamora Roland Dominic G. 
Published: February 2023

Abstract
Objective
To describe the association between hypertension and clinical outcomes in a cohort of patients with coronavirus disease 2019 (COVID-19).

Design
Retrospective cohort study.

Setting
Thirty-seven (37) hospitals in the Philippines.

Patients
10,881 patients admitted for COVID-19 from February to December 2020.

Measurements and main results
Among the 10,881 patients included in the Philippine CORONA Study, 3647 (33.5%) had hypertension. On regression analysis adjusted for confounders (age group, sex, smoking history, diabetes, chronic cardiac disease, chronic kidney disease, chronic respiratory disease, chronic neurologic disease, chronic liver disease, HIV/AIDS, and malignancy), patients with hypertension had significantly greater odds of in-hospital mortality (OR 1.33, 95% CI 1.17–1.52), respiratory failure (OR 1.99, 95% CI 1.75–2.28), ICU admission (OR 2.16, 95% CI 1.90–2.45) and severe/critical disease (OR 1.57, 95% CI 1.41–1.75), compared to patients without hypertension. The time-to-event analysis with confounder adjustment also showed that hypertension was significantly associated with shorter time-to-event outcomes of in-hospital mortality (HR 1.13, 95% CI 1.01–1.26), respiratory failure (HR 1.86, 95% CI 1.65–2.10), and ICU admission (HR 1.99, 95% CI 1.76–2.23).

Conclusions
Our analysis of nationwide data confirmed previous findings that hypertension is an independent risk factor for worse clinical outcomes among patients hospitalized for COVID-19, with increased odds of in-hospital mortality, respiratory failure, ICU admission, and severe/critical COVID-19. More specific studies should be done to elucidate the impact of hypertension characteristics, such as chronicity, severity, drug therapy, and level of control on these clinical outcomes.
Effect of postoperative utilization of somatostatin on clinical outcome after definitive surgery for duodenal fistula
Authors: Tian Weiliang , Zhao Risheng , Luo Shikun , Xu Xi , Zhao Guoping , Yao Zheng 
Published: February 2023

Abstract
Purpose
To evaluate the effect of postoperative utilization of somatostatin after definitive surgery for duodenal fistula (DF) in preventing a recurrence.

Methods
Patients with definitive surgery for DF between January 2010 and December 2021 were categorized based on the utilization of somatostatin or not after the surgery. Patients in the Somatostatin group were matched to those in the Non-somatostatin group using propensity scores matching (PSM), so as to evaluate the effect of postoperative use of somatostatin by comparing the two groups.

Results
A total of 154 patients were divided into the in the Somatostatin group (84) and the Non-somatostatin group (70). Forty-three patients (27.9%) exhibited a recurrent fistula, with which the postoperative use of somatostatin was not associated (19 [22.6%] in the Somatostatin group and 24 (34.3%) in the Non-somatostatin group; unadjusted OR 0.56; 95% CI 0.28–1.14; P = 0.11). However, the postoperative usage of somatostatin served as a protective factor for developing into high-output recurrent fistula (eight (13.3%) in the Somatostatin group and 15 (25%) in the Non-somatostatin group; adjusted OR 0.39; 95% CI 0.15–0.93; P = 0.04). After PSM, the recurrent fistula occurred in 29.2% subjects (35/120). The postoperative usage of somatostatin was not associated with recurrent fistula (13 in PSM Somatostatin group vs. 22 in PSM Non-somatostatin group; unadjusted OR 0.48; 95% CI 0.21–1.07; P = 0.07), while its postoperative usage decreased the incidence of recurrent high-output fistula (5/60 in the PSM Somatostatin group, compared with 13/60 in the PSM Non-somatostatin group; adjusted OR 0.30; 95% CI 0.09–0.95).

Conclusion
Postoperative use of somatostatin could effectively reduce the incidence of recurrent high-output fistula, without association with overall incidence of postoperative recurrent fistula.
Prediction of hypotension during the alveolar recruitment maneuver in spine surgery: a prospective observational study
Authors: Min Ji Young , Chang Hyun Jae , Kim Sung Jun , Cha Seung Hee , Jeon Joon Pyo , Kim Chang Jae , Chung Mee Young 
Published: February 2023

Abstract
Background
Atelectasis can occur in many clinical practices. One way to prevent this complication is through the alveolar recruitment maneuver (ARM). However, hemodynamic compromise can accompany ARM. This study aims to predict ARM-induced hypotension using a non-invasive method.

Methods
94 American Society of Anesthesiologists physical status I–II patients aged 19 to 75 with scheduled spinal surgery were enrolled. After anesthesia, we performed a stepwise ARM. Data on perfusion index, mean arterial pressure, heart rate, pleth variability index, cardiac index, and stroke volume variation was collected before induction of anesthesia (T0), just before ARM (T1), at the start of ARM (T2), 0.5 min (T3), 1 min (T4), 1.5 min (T5, end of ARM), and 2 min after the beginning of ARM (T6). Hypotension was defined as when the mean arterial pressure at T5 decreased by 20% or more compared to the baseline. The primary endpoint is that the perfusion index measuring before induction of anesthesia, which reflects the patients’ own vascular tone, was correlated with hypotension during ARM.

Results
Seventy-five patients (79.8%) patients developed hypotension during ARM. The pre-induction persufion index (Pi) (95% confidence interval) was 1.7(1.4–3.1) in the non-hypotension group and 3.4(2.4–3.9) in the hypotension group. (p < 0.004) The hypotension group showed considerably higher Pi than the non-hypotension group before induction. The decrease of Pi (%) [IQR] in the non-hypotensive group (52.8% [33.3–74.7]) was more significant than in the hypotensive group. (36% [17.6–53.7]) (p < 0.05) The area under the receiver operating characteristic curve of Pi for predicting hypotension during ARM was 0.718 (95% CI 0.615–0.806; p = 0.004), and the threshold value of the Pi was 2.4.

Conclusion
A higher perfusion index value measuring before induction of anesthesia can be used to predict the development of hypotension during ARM. Prophylactic management of the following hypotension during ARM could be considered in high baseline Pi patients.
Mental simulations to facilitate teacher learning of ambitious mathematics instruction in coaching interactions
Authors: Walsh Marguerite E. , Witherspoon Eben B. , Schunn Christian D. , Matsumura Lindsay Clare 
Published: February 2023

Abstract
Background
Many studies have shown that ambitious, “student centered” approaches to STEM instruction benefit K-12 student learning. However, relatively little research has systematically investigated the learning processes that support teachers to skillfully enact these challenging pedagogies. In this study, we used a mixed-methods, case-comparison design to examine one kind of teacher learning routine, Mental Simulations for Teacher Reflection (MSTR), for advancing robust teacher learning in the context of one mathematics-focused instructional coaching intervention. Specifically, this study draws from a large, state-wide representative dataset to select carefully matched, contrasting cases to analyze the quality of coach–teacher conversations for teachers who showed very similar baseline instructional quality but then large differences in levels of improvement. We began by qualitatively coding detailed transcripts from selected coach–teacher pairs as they reflected on lesson artifacts (i.e., lesson plans, student work, and coach observations) using MSTR as an analytical lens. Next, quantitative analyses were conducted to determine the extent to which mental simulations characterized significant differences in the conversations of high- vs. low-instructional growth pairs. Lastly, additional qualitative analyses explored finer-grain distinctions in the quality of mental simulation talk in high- vs. low-growth pairs.

Results
Quantitative analyses showed high-growth pairs were significantly more likely to engage in mental simulation talk compared to their low-growth counterparts. Moreover, the high-growth pairs were much more likely to initiate (i.e., raise an instructional ambiguity or problem for discussion) as well as complete (i.e., generate and weigh alternative instructional strategies) a MSTR routine. Qualitative analyses further revealed that engaging teachers’ in-depth pedagogical reasoning to connect specific teaching moves to conceptual learning goals in mental simulations was a key distinction of the high-growth coaches.

Conclusions
These findings indicate MSTR captured meaningful variation in coaching quality in this context. Notably, all coaches discussed the same instructional topics with teachers (i.e., teaching–learning goals and dimensions) and engaged in the same training that did not explicitly include MSTR, suggesting the possibility that MSTR captured a more implicit process of effective coaches. This study thus offers insight into the ‘black box’ of teacher learning and how it can be supported in similar professional learning contexts.
Pre-eruptive dynamics at the Campi Flegrei Caldera: from evidence of magma mixing to timescales estimates
Authors: Petrelli Maurizio , Ágreda López Mónica , Pisello Alessandro , Perugini Diego 
Published: February 2023

AbstractWe review pre-eruptive dynamics and evidence of open-system behavior in the volcanic plumbing system beneath Campi Flegrei Caldera, together with estimates of magma residence time, magma ascent, and mixing-to-eruption timescales. In detail, we compile pre- and syn-eruptive dynamics reported in the literature for (a) the Campanian Ignimbrite ~ 40 ka, (b) the Neapolitan Yellow Tuff (~ 15 ka), and (c) the recent activity within the Phlegrean area. We first summarize geochemical and textural evidence (e.g., magma mixing, crystal disequilibria, vertical zonings, and isotopic records) of open-system behavior for the pyroclasts erupted in the last 40 ky at Campi Flegrei Caldera. We show that the fingerprint of open-system dynamics is ubiquitous in the deposits associated with the volcanic activity at the Campi Flegrei Caldera in the last 40 ky. Then, we describe the results of geophysical and petrological investigations that allow us to hypothesize the structure of the magma feeding system. We point to a trans-crustal magmatic feeding system characterized by a main storage reservoir hosted at ~ 9 km that feeds and interacts with shallow reservoirs, mainly placed at 2–4 km. Finally, we define a scenario depicting pre-eruptive dynamics of a possible future eruption and provide new constraints on timescales of magma ascent with a physical model based on magma-driven ascending dyke theory. Results show that considerably fast ascent velocities (i.e., of the order of m/s) can be easily achieved for eruptions fed by both shallow (i.e., 3–4 km) and deep (i.e., ~ 9 km) reservoirs. Comparing the results from experimental and numerical methods, it emerges that mixing-to-eruption timescales occurring at shallow reservoirs could be on the order of minutes to hours. Finally, we highlight the volcanological implications of our timescale estimates for magma ascent and mixing to eruption. In particular, explosive eruptions could begin with little physical ‘warning’, of the order of days to months. In this case, the onset of volatile saturation might provide pre-eruptive indicators.
Graphical Abstract
Lower gut dysbiosis and mortality in acute critical illness: a systematic review and meta-analysis
Authors: Evans Tess , Ali Umar , Anderton Ryan , Raby Edward , Manning Laurens , Litton Edward 
Published: February 2023

Abstract
Background
The human gastrointestinal tract harbours a complex multi-kingdom community known as the microbiome. Dysbiosis refers to its disruption and is reportedly extreme in acute critical illness yet its clinical implications are unresolved. The review systematically evaluates the association between gut dysbiosis and clinical outcomes of patients early in critical illness.

Methods
Following PRISMA guidelines, a prospectively registered search was undertaken of MEDLINE and Cochrane databases for observational studies undertaking metagenomic sequencing of the lower gastrointestinal tract of critically ill adults and children within 72 h of admission. Eligible studies reported an alpha diversity metric and one or more of the primary outcome, in-hospital mortality, or secondary clinical outcomes. After aggregate data were requested, meta-analysis was performed for four studies with in-hospital mortality stratified to high or low Shannon index.

Results
The search identified 26 studies for systematic review and 4 had suitable data for meta-analysis. No effect of alpha diversity was seen on in-hospital mortality after binary transformation of Shannon index (odds ratio 0.52, CI 0.12–4.98, I2 = 0.64) however certainty of evidence is low. Pathogen dominance and commensal depletion were each more frequently associated with in-hospital mortality, adverse clinical and ecological sequelae, particularly overabundance of Enterococcus.

Conclusions
There is a paucity of large, rigorous observational studies in this population. Globally, alpha diversity was dynamically reduced in early ICU admission in adults and children and was not associated with in-hospital mortality. The abundance of taxa such as Enterococcus spp. appears to offer greater predictive capacity for important clinical and ecological outcomes.
White-light crosslinkable milk protein bioadhesive with ultrafast gelation for first-aid wound treatment
Authors: Zhu Qinchao , Zhou Xuhao , Zhang Yanan , Ye Di , Yu Kang , Cao Wangbei , Zhang Liwen , Zheng Houwei , Sun Ziyang , Guo Chengchen , Hong Xiaoqian , Zhu Yang , Zhang Yajun , Xiao Ying , Valencak Teresa G. , Ren Tanchen , Ren Daxi 
Published: February 2023

Abstract

Background

Post-traumatic massive hemorrhage demands immediately available first-aid supplies with reduced operation time and good surgical compliance.
In-situ
crosslinking gels that are flexibly adapting to the wound shape have a promising potential, but it is still hard to achieve fast gelation, on-demand adhesion, and wide feasibility at the same time.

Methods
A white-light crosslinkable natural milk-derived casein hydrogel bioadhesive is presented for the first time. Benefiting from abundant tyrosine residues, casein hydrogel bioadhesive was synthesized by forming di-tyrosine bonds under white light with a ruthenium-based catalyst. We firstly optimized the concentration of proteins and initiators to achieve faster gelation and higher mechanical strength. Then, we examined the degradation, cytotoxicity, tissue adhesion, hemostasis, and wound healing ability of the casein hydrogels to study their potential to be used as bioadhesives.

Result
Rapid gelation of casein hydrogel is initiated with an outdoor flashlight, a cellphone flashlight, or an endoscopy lamp, which facilitates its usage during first-aid and minimally invasive operations. The rapid gelation enables 3D printing of the casein hydrogel and excellent hemostasis even during liver hemorrhage due to section injury. The covalent binding between casein and tissue enables robust adhesion which can withstand more than 180 mmHg blood pressure. Moreover, the casein-based hydrogel can facilitate post-traumatic wound healing caused by trauma due to its biocompatibility.

Conclusion
Casein-based bioadhesives developed in this study pave a way for broad and practical application in emergency wound management.
The digital competence of academics in higher education: is the glass half empty or half full?
Authors: Inamorato dos Santos Andreia , Chinkes Ernesto , Carvalho Marco A. G. , Solórzano Claudia M. V. , Marroni Lilian S. 
Published: February 2023

AbstractThis paper aims to evaluate and discuss the digital competence of academics at universities, to identify challenges and define recommendations for policy. This study was conducted through collaboration between the Joint Research Centre (JRC) of the European Commission and Metared of the Universia Foundation, surveying 30,407 participants who present the perceptions of their own digital competence levels. These self-reflections took place in universities in seven countries, namely Argentina, Brazil, Colombia, Chile, Peru, Mexico and Portugal, and used the Check-In tool, which consists of 22 questions based on the European Framework for the Digital Competence of Educators—or ‘DigCompEdu’ framework. A descriptive statistical analysis was performed, followed by a qualitative evaluation. Almost 70% of the academics have an average intermediate level of competence when the data is aggregated, with results varying in each DigCompEdu area according to the specific question asked. There is no significant difference between young and senior academics, as well as between men and women. The results present a discussion of whether the age and gender of educators and their work environment have an impact on their digital competence level, and at the same time highlights the areas in which educators perceive themselves to be most and least competent. It shows how the amount of institutional support that is offered affects the academics’ perceptions of their level of digital competence. On the basis of the results, recommendations are presented for higher-education institutions, with the aim of supporting the professional development of their academics.