bluuebunny/crossref_metadata_2025_split huggingface dataset:
DESAIGN AND SIMULATION OF ADC CIRCUITS COMPILED BY IC ADC0804 AND IC ADC0809
Authors: Amril Muhammad , Sihombing Panangian Mahadi , Sukarwoto Sukarwoto 
Published: April 2023

Abstract: Medan Aviation Polytechnic is one of the campuses under the ministry of transportation which has a major in telecommunication and air navigation engineering in Indonesia. Based on field surveys, an Analog to Digital Converter (ADC) practicum kit is needed to improve the ability of cadets. Based on this background, this study aims to design and simulate two ADC circuits, each of which is compiled by the integrated circuit (IC) ADC0804 and IC ADC0809 respectively. Three statistical formulas, namely mean error (ME), standard deviation error (SDE), and root mean square error (RMSE) are used to measure the performance of the two ADC circuits. Both ADC circuits are simulated using a Proteus 8.11 Simulator with 255 analog input voltages. Based on the result of the study, it is known that the ADC circuit compiled by IC ADC0809 is more accurate than the ADC circuit compiled by IC ADC0804. This is evidenced by a smaller error value, which is based on the simulation results of the ME, SDE, and RMSE values were 0.4210, 0.3410, and 0.5110, respectively. And, based on the measurement results, it has ME, SDE, RMSE respectively, namely 0.8510, 0.8110, and 0.9310. Keywords: ADC; Proteus 8.11 Simulator; IC ADC0804; IC ADC0809; ME; SDE; RMSE Abstrak: Politeknik Penerbangan Medan adalah salah satu kampus di bawah Kementerian Perhubungan yang memiliki jurusan teknik telekomunikasi dan navigasi udara di Indonesia. Berdasarkan survei di lapangan, kit praktikum konverter analog ke digital diperlukan untuk meningkatkan kemampuat taruna. Berdasarkan latar belakang tersebut, penelitian ini bertujuan merancang dan mensimulasi dua rangkaian ADC yang masing-masing disusun oleh IC ADC0804 dan IC ADC0809. Tiga formula statistik, yaitu mean error (ME), standard deviation error (SDE), and root mean square error (RMSE) digunakan untuk mengukur kinerja kedua rangkaian ADC tersebut. Kedua rangkaian ADC tersebut disimulasi menggunakan Simulator Proteus 8.11 dengan 255 tegangan masukan analog. Berdasarkan hasil penelitian diketahui bahwa rangkaian ADC yang disusun oleh IC ADC0809 lebih akurat dibandingkan dengan rangkaian ADC yang disusun oleh IC ADC0804. Hal tersebut dibuktikan dengan nilai kesalahan yang lebih kecil, yaitu berdasarkan hasil simulasi memiliki ME, SDE, RMSE masing-masing adalah 0,4210, 0,3410 dan 0,5110. Dan berdasarkan hasil pengukuran memiliki ME, SDE, dan RMSE masing-masing adalah 0,8510, 0,8110, dan 0,9310. Kata kunci: ADC; Simulator Proteus 8.11; IC ADC0804; IC ADC0809; ME; SDE; RMSE
Properties and microstructure of total tailings cemented paste backfill material containing mining and metallurgical solid waste
Authors: Wang Changlong , Qi Yang , Jing Jianlin , Ma Jintao , Zhou Yongxiang , Ping Haoyan , Zheng Yongchao , Zhai Yuxin , Liu Feng 
Published: April 2023

Introduction: In order to improve the utilization efficiency of industrial waste discharged in the process of iron and steel metallurgy, a kind of material that can replace cement for mine filling is sought. In the test, steel slag (SS) and vanadium-titanium slag (VTS) were used as the primary raw materials to prepare cementing agents (CA). Then, combine it with vanadium-titanium iron ore tailings (VTIOTs) to make mine cemented paste backfill material (CPBM).Methods: The composition, properties and hydration mechanism of CPBM are studied through various tests, in-cluding mechanical property test, hydration heat test, X-ray diffraction (XRD), scanning electronic mi-croscopy (SEM), and fourier transform-infrared spectroscopy (FT-IR).Results: The results show that when the following conditions are met, the slump is 216 mm, and the 28-day flexural strength and compressive strength of CPBM reach 4.25 and 9.41 MPa, respectively, which meets the requirements of Chinese National Standard GB/T 39489-2020 Technical specification for the total tailings paste backfill: the mass percentage SS: VTS: phosphogypsum (PG): dicyandiamide waste slag (DWS) = 31:59:6:4; the content of compound phosphoric acid (CPA) accounts for 4% of the dry material; the cement sand ratio of CPBM is 1:4; the paste mass concentration (PMC) is 80%; and the content of water reducing agent (WRA) is 0.18%.Discussion: Mechanism studies show that the hydration product of the CA is mainly ettringite (AFt) and C-S-H gel. The addition of CPA promotes the hydration of active minerals in SS and VTS. The existence of PG pro-motes the formation of AFt, and the formation of AFt further promotes the fracture of [AlO4]5− and [SiO4]4− along the bridge oxygen in VTS and SS.
Impact of the COVID-19 pandemic on youth delinquency: A discontinuous growth analysis
Authors: Li Nan , Quintana Diana , Shelton Matthew , Grigorenko Elena L. 
Published: April 2023

IntroductionThis study aimed to investigate (a) the immediate and long-term changes in youth offending rates among 138 neighborhoods within a large metropolitan area in the context of COVID-19 and (b) the extent to which the socioeconomic composition of the neighborhoods accounted for variations of the changes.MethodsDiscontinuous growth models were applied to demonstrate the changes in offenses against a person, property offenses, and drug-related offenses one-year prior to, at (March 2020), and one-year following the pandemic.ResultsAt the onset of the pandemic, we registered an immediate reduction in offenses against a person and property offenses but not in drug-related offenses. There was a steeper declining trend for property offenses one-year following the pandemic as compared with that one-year prior to the pandemic. The neighborhood concentration of affluence and poverty was not related to the immediate reduction in any type of delinquency.DiscussionWe conclude that the COVID-19 pandemic not only had an abrupt but also an enduring impact on youth delinquency.
Analysis of sperm chromatin packaging and reproductive biomarker to evaluate the consequence of advanced male age
Authors: Bibi Riffat , Jahan Sarwat , Kafeel Qureshi Salma , Razak Suhail , Afsar Tayyaba , Almajwal Ali , Kafeel Qureshi Mashal , Hammadeh Mohammad Eid , Amor Houda 
Published: April 2023

In this study, the semen parameters, sperm chromatin integrity, antioxidant enzyme levels, and reproductive hormone levels of subfertile male subjects from Pakistan were assessed in relation to their age. Data on the demographic characteristics of the 750 study participants, including their general health, body mass index (BMI), and reproductive status, were collected from subfertile men from Pakistan. Semen and blood were collected to determine standard semen parameters, sperm chromatin dispersion (Halosperm-SCD), sperm chromatin integrity using toluidine blue (TB) staining, sperm chromatin maturity using chromomycin A3 (CMA3+) staining, and reproductive hormone (FSH, LH, prolactin and testosterone levels). The patients were divided into three groups according to their age: Group 1 included male subjects aged 30 years or less (n= 90), Group 2 included male subjects between the ages of 31 and 40 years (n= 330), and Group 3 included male subjects over 40 years of age (n= 330). Conventional semen parameters, reactive oxygen species (ROS), superoxide dismutase (SOD), guaiacol peroxidase (GPX), catalase (CAT), and lipid peroxidation (MDA) did not statistically (p&gt; 0.05) differ with increasing male age or between different age groups. When compared to younger men (&lt;30 years), sperm SCD (23.2 ± 0.88%) was significantly (p= 0.01) lower as compared to male patients aged &gt;40 years (26.6 ± 0.6%). The concentration of LH, FSH, and testosterone levels were comparable between the groups (p&gt; 0.05), while a significant (p= 0.04) increase in sperm chromatin immaturity CMA3+ (30 ± 0.71%) was observed in the old age group (&gt;40 years) compared to the &lt;30-year group (26.6 ± 1.03%). A positive association was observed between advanced male age and sperm chromatin dispersion (SCD) (r= 0.124,p= 0.001) and decondensation (CMA3+) (r= 0.1,p= 0.009). Despite potential limitations, this study has been carried out with extensive information on the potential risk of male age on sperm integrity. The present study demonstrated the impact of male age on male reproductive health, as these patients had a higher percentage of sperm chromatin damage (SCD) in their semen. Sperm DNA damage assessment will help in the evaluation and diagnosis of the underlying cause of poor fertility and can help clinicians in selecting the right treatment options. Male age is one of the factors that have an impact on the decline in male fertility. As a result, it is preferable for patients receiving assisted reproductive technology to be younger.
Proteome profiling of endogenous and potential S-nitrosylation in colorectal cancer
Authors: Liang Feng , Wang Shuang , Guo Yu , Mu Yu , Shang FengJia , Wang Min 
Published: April 2023

BackgroundAs a common cancer with high incidence rate and mortality, colorectal cancer (CRC) is seriously threatening human health. S-nitrosylation (SNO) proteins mediated by nitric oxide (NO) has important implications in the genesis, progression, and apoptosis of CRC. It’s worth noting that the SNO proteins also play an important role in the tumor endocrine and metabolic pathways of CRC.Materials and methodsIn this study, the protein extracts of human tissues and cell lines were treated by biotin switch technology and magnetic beads enrichment. The proteomic results of endogenous and potential SNO proteins were analyzed by mass spectrometry (MS). Through the comparison and analysis of MS results, Gene Ontology (GO) analysis, and literatures, some endogenous and potential SNO proteins were identified in CRC, which were closely related to the tumor endocrine and metabolic pathways, the apoptotic signaling pathways, protein maturation, and other biological processes of the proliferation and apoptosis of CRC cells.ResultsA total of 19 proteins containing potential or endogenous SNO sites were detected in both human cancer tissue and SW 480 cells. Through the cross validation of MS results, GO analysis, and literatures, several SNO proteins were identified frequently in CRC, such as the actin, cytoplasmic 1 (ACTB), peroxiredoxin-4 (PRDX4), protein S100A8 (S100A8), pyruvate kinase PKM (PKM), glyceraldehyde-3-phosphate dehydrogenase (GAPDH), which were closely related to the tumor endocrine and metabolic pathways and the apoptotic signaling pathways of CRC.ConclusionDifferent CRC cells and tissues contained potential and endogenous SNO modified proteins. In addition, some SNO proteins could participate in the proliferation, metastasis and apoptosis of CRC by regulating the tumor endocrine and metabolic pathways.
Prelaryngeal and/or pretracheal lymph node metastasis could help to identify papillary thyroid carcinoma with intermediate risk from unilateral lobe cT1-2N0 papillary thyroid carcinoma
Authors: Wang Bin , Zhu Chun-Rong , Fei Yuan , Liu Hong , Yao Xin-Min , Wu Jian 
Published: April 2023

ObjectiveThe study aims to explore the possibility of prelaryngeal and/or pretracheal lymph node metastasis in identifying papillary thyroid carcinoma with more than 5 metastatic central lymph nodes from unilateral lobe cT1-2N0 papillary thyroid carcinoma.MethodsA retrospective analysis was conducted on patients who underwent the initial thyroid surgery for unilateral lobe cT1-2N0 PTC in a single tertiary center between July 2018 to December 2022. Multivariable binary logistic regression analysis was used to identify risk factors for unilateral lobe cT1-2N0 papillary thyroid carcinoma with more than 5 metastatic central lymph nodes.ResultsA total of 737 patients were included in the study and 399 patients were confirmed to suffer from occult central lymph node metastasis. The larger size of the largest diameter of tumor (&gt; 1cm; OR = 3.3, 95%CI 1.6 – 6.83; p = 0.001), pretracheal lymph node metastasis (OR = 5.91, 95%CI 2.73 – 12.77; p &lt; 0.001), prelaryngeal lymph node metastasis (OR = 3.74, 95%CI 1.73 – 8.1; p = 0.001), ipsilateral paratracheal lymph node metastasis (OR = 12.22, 95%CI 3.43 – 43.48; p &lt; 0.001), and contralateral paratracheal lymph node metastasis (OR = 7.68, 95%CI 3.86 – 15.3; p &lt; 0.001) were confirmed to be risk factors for unilateral lobe cT1-2N0 PTC with more than 5 metastatic central lymph nodes. When more than two metastatic prelaryngeal and/or pretracheal lymph nodes occurred, the incidence of more than 5 metastatic central lymph nodes was 71.2%.ConclusionPrelaryngeal and/or pretracheal lymph node metastasis could help to identify papillary thyroid carcinoma with more than 5 metastatic central lymph nodes from unilateral lobe cT1-2N0 papillary thyroid carcinoma. When more than two metastatic pretracheal and/or prelaryngeal lymph nodes occurred, total thyroidectomy and ipsilateral central lymph node dissection should be performed and contralateral paratracheal lymph node dissection might be also necessary.
A sigmoid-based adaptive inertia control strategy for grid-forming inverter to enhance frequency stability
Authors: Huang Renzhi , Dong Chen , Wu Zaijun , Quan Xiangjun , Wang Zichen , Sun Tiankui , Hou Kai 
Published: April 2023

Introduction: This paper proposes a sigmoid-based adaptive inertia control strategy for grid-forming (GFM) inverter to enhance frequency stability.Methods: Firstly, the frequency response characteristics under different disturbances are analyzed theoretically. Then, to solve the problem that fixed inertia leads to a contradiction between the maximum frequency deviation and the setting time, a non-linear inertia regulator is investigated. This non-linear inertia regulator, which is based on an improved sigmoid function, is applied to achieve real-time inertia by the frequency deviation. Moreover, the full-order small-signal model of the system containing the nonlinear inertia regulator is established and thus the stability of the proposed strategy is analyzed.Result and Discussion: The proposed control strategy is implemented without derivative action, which may suffer from high-frequency noises. Finally, the hardware-inthe-loop (HIL) results verify the remarkable performance of the proposed control strategy.
Assessment of electrified ethylene production via biomass gasification and electrochemical CO reduction
Authors: Klüh Daniel , Nieminen Harri , Melin Kristian , Laari Arto , Koiranen Tuomas 
Published: April 2023

The chemical industry needs new methods for sourcing carbon-containing feedstocks from renewable sources to decrease CO2emissions and reduce reliance on fossil fuels. Ethylene, a crucial base chemical used for making polymers and ethylene oxide, is primarily produced through steam cracking of fossil feedstocks. However, an evolving technology is the electrochemical reduction of CO2or CO to produce ethylene. The study assesses the environmental, economic and energetic performance of a new biomass-based process that produces ethylene based on the electrochemical reduction of CO. The results are based on mass and energy balances from process simulation. The CO is produced by either gasification of biomass or combustion of biomass with CO2capture and CO2electrolysis. Besides ethylene, the process produces acetic acid, ethanol, oxygen and hydrogen as by-products which are purified and sold. The annual output varies between 36 and 68 kt ethylene with a biomass input of 157 kt. The levelized cost of ethylene ranges from 3,920 to 7,163 €/t with the gasification routes being the most cost-effective. The ethylene price is heavily dependent on electricity price, current density, operating voltage, and by-product prices. The carbon efficiency of the gasification-based routes is lower (64%) than the combustion-based routes (85%–86%). However, the energy efficiency is higher for the gasification-based routes (42%) compared to the combustion-based routes (28%). Conversion of ethanol to ethylene increases the ethylene yield with minimal impacts on the ethylene price. In terms of CO2emissions, the gasification-based routes show lower emissions. Scenarios using wind power show a significant emission reduction potential compared to fossil products.
Unveiling DNA damage repair-based molecular subtypes, tumor microenvironment and pharmacogenomic landscape in gastric cancer
Authors: Kong Weiqi , Wang Zhiqiang , Wang Bingyi 
Published: April 2023

Objective: The current molecular classification system for gastric cancer covers genomic, molecular, and morphological characteristics. Non-etheless, classification of gastric cancer based upon DNA damage repair is still lacking. Here, we defined DNA damage repair-based subtypes across gastric cancer and identified clinicopathological, tumor microenvironment and pharmacogenomic features.Methods: Unsupervised clustering analysis was executed in the TCGA-STAD cohort based upon the transcriptional expression profiling of DNA damage repair genes. LASSO computational approach was adopted for generating a DNA damage repair-relevant gene signature. The identified subtypes or signature were externally verified in the GSE84426 or GSE84433 cohort. The transcriptional levels of immunomodulators, abundance of immune cells and somatic mutations were measured, respectively. Immunotherapeutic response, and drug sensitivity were investigated. The DNA damage repair-relevant genes were further experimentally verified.Results: Two DNA damage repair-based subtypes were identified, with the notable heterogeneity in prognostic stratification, tumor microenvironment and somatic mutations. The gene signature was generated for risk stratification and prognostic prediction, which was in relation to immunomodulators and immune cells. High-risk cases were more likely to respond to immunotherapy, with distinct pharmacogenomic landscapes between low- and high-risk groups. Higher levels of PAPPA2, MPO, MAGEA11, DEPP1, CPZ, and COLEC12 and lower level of CYTL1 were proven in gastric cancer cells versus controls. Silencing CYTL1 facilitated intracellular ROS accumulation and suppressed migration in gastric cancer cells.Conclusion: Collectively, the DNA damage repair-based classification is a suitable complement to existing molecular classification system, and the quantitative gene signature provides a robust tool in selecting specific therapeutic options.
An effective prognostic model for assessing prognosis of non-small cell lung cancer with brain metastases
Authors: Wang Rong , Zhang Xing , He Changshou , Guo Wei 
Published: April 2023

Background: Brain metastasis, with an incidence of more than 30%, is a common complication of non-small cell lung cancer (NSCLC). Therefore, there is an urgent need for an assessment method that can effectively predict brain metastases in NSCLC and help understand its mechanism.Materials and methods: GSE30219, GSE31210, GSE37745, and GSE50081 datasets were downloaded from the GEO database and integrated into a dataset (GSE). The integrated dataset was divided into the training and test datasets. TCGA-NSCLC dataset was regarded as an independent verification dataset. Here, the limma R package was used to identify the differentially expression genes (DEGs). Importantly, the RiskScore model was constructed using univariate Cox regression analysis and least absolute shrinkage and selection operator (LASSO) analysis. Moreover, we explored in detail the tumor mutational signature, immune signature, and sensitivity to treatment of brain metastases in NSCLC. Finally, a nomogram was built using the rms package.Results: First, 472 DEGs associated with brain metastases in NSCLC were obtained, which were closely associated with cancer-associated pathways. Interestingly, a RiskScore model was constructed using 11 genes from 472 DEGs, and the robustness was confirmed in GSE test, entire GSE, and TCGA datasets. Samples in the low RiskScore group had a higher gene mutation score and lower immunoinfiltration status. Moreover, we found that the patients in the low RiskScore group were more sensitive to the four chemotherapy drugs. In addition, the predictive nomogram model was able to effectively predict the outcome of patients through appropriate RiskScore stratification.Conclusion: The prognostic RiskScore model we established has high prediction accuracy and survival prediction ability for brain metastases in NSCLC.
Type 1 interferon mediated signaling is indispensable for eliciting anti-tumor responses by Mycobacterium indicus pranii
Authors: Roy Gargi , Chakraborty Anush , Swami Bharati , Pal Lalit , Ahuja Charvi , Basak Soumen , Bhaskar Sangeeta 
Published: April 2023

IntroductionThe evolving tumor secretes various immunosuppressive factors that reprogram the tumor microenvironment (TME) to become immunologically cold. Consequently, various immunosuppressive cells like Tregs are recruited into the TME which in turn subverts the anti-tumor response of dendritic cells and T cells.Tumor immunotherapy is a popular means to rejuvenate the immunologically cold TME into hot. Mycobacterium indicus pranii (MIP) has shown strong immunomodulatory activity in different animal and human tumor models and has been approved for treatment of lung cancer (NSCLC) patients as an adjunct therapy. Previously, MIP has shown TLR2/9 mediated activation of antigen presenting cells/Th1 cells and their enhanced infiltration in mouse melanoma but the underlying mechanism by which it is modulating these immune cells is not yet known.ResultsThis study reports for the first time that MIP immunotherapy involves type 1 interferon (IFN) signaling as one of the major signaling pathways to mediate the antitumor responses. Further, it was observed that MIP therapy significantly influenced frequency and activation of different subsets of T cells like regulatory T cells (Tregs) and CD8+ T cells in the TME. It reduces the migration of Tregs into the TME by suppressing the expression of CCL22, a Treg recruiting chemokine on DCs and this process is dependent on type 1 IFN. Simultaneously, in a type 1 IFN dependent pathway, it enhances the activation and effector function of the immunosuppressive tumor resident DCs which in turn effectively induce the proliferation and effector function of the CD8+ T cells.ConclusionThis study also provides evidence that MIP induced pro-inflammatory responses including induction of effector function of conventional dendritic cells and CD8+ T cells along with reduction of intratumoral Treg frequency are essentially mediated in a type 1 IFN-dependent pathway.
Case Report: Severe rebound after withdrawal of fingolimod in a patient with neuromyelitis optica spectrum disorder
Authors: Lin Wei , Chou Chung-Hsing , Yang Fu-Chi , Tsai Chia-Kuang , Lin Yu-Kai , Sung Yueh-Feng 
Published: April 2023

PurposeFingolimod, an oral treatment for relapsing-remitting multiple sclerosis (RRMS), has been associated with a significant rebound in disease activity after therapy cessation. We described a patient with neuromyelitis optica spectrum disorder (NMOSD) who was previously diagnosed with RRMS and experienced fatal rebound syndrome after cessation of fingolimod.Case reportA 54-year-old woman, previously diagnosed with RRMS, experienced relapse after orthopedic surgery. The diagnosis was later revised to NMOSD based on a positive aquaporin-4 antibody. Three weeks after converting the immunomodulator from fingolimod to azathioprine, severe disease reactivation was observed. Considering the multiple new and enlarging magnetic resonance imaging lesions, the temporal relationship between fingolimod cessation and symptom onset, and the relatively low possibility of disease reactivation within a short time, the diagnosis of fingolimod withdrawal syndrome was proposed. Although immediate steroid pulse therapy and plasma exchange were performed, the patient eventually died owing to a fulminant clinical course.ConclusionFingolimod withdrawal syndrome is well known in patients with multiple sclerosis (MS). It can also occur in patients with NMOSD. Recognizing patients with NMOSD who present with MS-like manifestations, and avoiding drugs that may be harmful to patients with NMOSD, are important.