bluuebunny/crossref_metadata_2025_split huggingface dataset:
Design of an ultrasound appointment system based on a patient-centered real-time dynamic resource allocation strategy
Authors: Zhang Yong , Luo Yan , Qiu Li , Zhu Ying , Lu Xiao 
Published: February 2025

IntroductionThe existing ultrasound appointment system faces multiple challenges, including a lack of diversity in its operation modes, sluggish efficiency, and limited flexibility. During emergency situations, such as disease outbreaks or severe disaster events, the demand for ultrasound examinations skyrockets, making it imperative to offer patients efficient and user-friendly ultrasound appointment services.MethodsThis study introduces the application of a patient-centered real-time dynamic resource allocation strategy in an ultrasound appointment system. This strategy focuses on the demand of patients, builds a multichannel and multimode ultrasound appointment system, and opens sets of parameters related to ultrasound appointments, such as examination room attributes, workload adjustments, and mutually exclusive rules of medical orders. The system can display patient appointment data in real time and carry out statistical analysis, and medical resources can be flexibly configured according to the patient appointment situation to fully meet the needs of patients. Moreover, the system interconnects the appointment data with the registration system and the examination room examination list to further optimize the medical service process.ResultsData such as the proportion of appointment channels, appointment time, and the quality and efficiency of ultrasound examinations before and after the introduction of the appointment system were compared and analyzed. According to the statistics, the proportion of online bookings increased from 0% to 81.42%. The average appointment times of general ultrasound examination and specialist ultrasound examination were reduced by 90.7% and 78.86%, respectively. The appointment staff was saved by 4 people, the average waiting time of patients in the examination area was reduced from 42 min to 11 min, and the number of ultrasound examinations was increased by 11.5%, while the number of error reports was also significantly reduced.DiscussionThe results show that the application of this strategy in an ultrasound appointment system is feasible and efficient. Patients can participate more in the entire process of ultrasound appointment and examination, obtain reliable ultrasound medical services faster and more efficiently, improve the diagnosis and treatment environment and order of the hospital, and optimize the medical service process.
Spatial variation and predictors of anemia among women of reproductive age in Mozambique, 2022/23: a multiscale geographically weighted regression
Authors: Gebrehana Deresse Abebe , Tamir Tadesse Tarik , Molla Gebretsadik Endeshaw , Kebede Yishak , Tegegne Dejen , Nigatu Solomon Gedlu , Nigatu Araya Mesfin 
Published: February 2025

IntroductionAnemia is a critical global public health issue, especially among women of reproductive age (15–49 years) in low- and middle-income countries. Mozambique has the highest prevalence of anemia in women of reproductive age in Sub Saharan Africa in 2019. This study aims to assess the spatial variation and predictors of anemia among women of reproductive age in Mozambique.MethodsIndividual record and spatial coordinates data from the Mozambique Demographic and Health Survey (DHS 2022/23) were used. A stratified two-stage cluster sampling method was applied. Global autocorrelation analysis was performed to determine clustering of anemia. A weighted sample of 5,907 women of reproductive age was analyzed using ArcGIS 10.7. Multiscale geographically weighted regression was employed to identify predictors of anemia.ResultsThe national prevalence of anemia among women of reproductive age in Mozambique was 51.89% (95% CI: 50.66, 53.12%). Higher rates were observed in Nampula, Zambezia, and Sofala. Unimproved drinking water, pregnancy, and being underweight were positively correlated with anemia, while contraceptive use and obesity were negatively correlated. Geographic variability in these associations was evident (Global Moran’s I = 0.0.444359 and p &lt; 0.001). Anemia was the highest in Tete and Manica due to unimproved drinking water the effect of pregnancy on anemia was significant in Manica and Sofala. Being underweight was strongly related to anemia in Niassa. Conversely, contraceptive use and obesity had a protective effect in Nampula, Zambezia, Niassa, and Cabo Delgado.ConclusionAnemia remains a critical public health issue among women of reproductive age in Mozambique, with marked regional disparities. Hotspot clusters were identified in Nampula, Zambezia, Tete, and Sofala. Factors such as unimproved drinking water, pregnancy, and being underweight were associated with higher anemia rates in certain regions, while obesity and contraceptive use indicated a protective effect in specific provinces. To effectively combat anemia, policymakers should focus on improving access to clean water and maternal health services, and enhancing nutritional support through the USAID Advancing Nutrition Project, the Global Alliance for Improved Nutrition, Integrated Community Case Management, and Supervised Weekly Iron and Folic Acid Supplementation.
Exploring adolescents' mental health in Kampala, Uganda in the context of COVID-19: a mixed methods study
Authors: Mbithi Gideon , Sarki Ahmed , Mabrouk Adam , Odhiambo Rachel , Namuguzi Mary , Atukwatse Joseph , Kabue Margaret , Mulupi Stephen , Abubakar Amina 
Published: February 2025

BackgroundUrban areas, particularly in developing nations like Uganda, face heightened risks due to poverty, unemployment, and environmental challenges, intensifying the vulnerability of urban youth to poor mental health. This study aims to determine the psychological well-being of adolescents and to assess the risks and associated factors of mental health problems among adolescents in the context of COVID-19 pandemic in Kampala City, Uganda.MethodsWe conducted a cross-sectional survey of 500 adolescents aged 13–19 years residing within the five divisions of Kampala City, Uganda. We utilized standardized psychological assessment tools including the Patient Health Questionnaire, Generalized Anxiety Scale, to assess severity of depression and anxiety levels among the adolescents. A logistic regression model was used to evaluate the correlates associated with depression and generalized anxiety disorders. Variables with a p-value &lt;0.25 in the univariate model were included in the multivariable regression model. Subsequently, we conducted a qualitative study using semi-structured interview guides through focused group discussions, and key informant interviews with teachers, parents, representatives of civil society organizations, and religious leaders. Qualitative data were analyzed using a thematic analysis approach.ResultsThe prevalence of depression was relatively higher among out-of-school adolescents at 21.5% compared to school-going adolescents at 14.0%. Furthermore, out-of-school adolescents had significantly higher anxiety scores when compared to their school-going counterparts (17.5% vs. 10.3%) respectively. Key factors identified associated with poor mental health include loneliness, being out of school, COVID-19, and familial conflicts.DiscussionThis study highlights the impact of the COVID-19 pandemic on the mental well-being of adolescents in Kampala, Uganda. The reported prevalence of depression and anxiety, particularly among out-of-school adolescents, underscores the urgent need for targeted interventions in this vulnerable population. Investing in the mental well-being of Ugandan adolescents is paramount for fostering resilience and ensuring long-term success, especially in marginalized urban settings.
Modeling and experimental analysis of protein matrix solidification in cooling dies during high-moisture extrusion
Authors: Högg Elisabeth , Horneber Tobias , Rauh Cornelia 
Published: February 2025

IntroductionHigh-moisture extrusion (HME) has become a key method in the food industry for texturizing plant-based proteins to create high-moisture meat analogues (HMMAs) with meat-like textures. Despite its importance, the texturization process within the cooling die of the extruder remains not fully understood. This study aims to bridge this knowledge gap by combining experimental and numerical methods to analyze protein matrix solidification.MethodsIn-situ measurements, including temperature, pressure, velocity, and flow profiles, were conducted for various HME setups and die geometries. Numerical simulations based on the finite volume method incorporated thermophysical material properties from previous research to predict flow dynamics and structural changes. An inverse modeling approach was used to estimate unmeasurable parameters, and experimental validation included textural analysis, such as slice shear force and tensile strength.ResultsThe experimental and numerical studies showed strong agreement, validating the numerical model’s accuracy in simulating cooling die processes. Flow profiles visualized experimentally and numerically highlighted the correlation between structuring coefficients derived from kinematic variables and textural analysis results. Key findings indicated that cooling die geometries and process conditions significantly influence protein matrix solidification and the resulting texture of HMMAs.DiscussionThis study provides novel insights into the dynamics within cooling dies and establishes a robust framework for optimizing HME processes to enhance the textural quality of meat analogues. The validated numerical model enables future studies to explore diverse geometries and process conditions, contributing to advancements in plant-based protein texturization.
The tumor coagulome as a potential biological determinant of postsurgical recurrence of oral squamous cell carcinoma
Authors: Saidak Zuzana , Galmiche Antoine 
Published: February 2025

ObjectivesThe tumor coagulome is an intrinsic characteristic of human tumors and a key determinant of cancer-associated thrombosis (CAT). Oral Squamous Cell Carcinoma (OSCC) establish a local procoagulant state that contributes to a broad range of vascular complications, and potentially also to tumor progression. Recent clinical studies suggest that biomarkers of coagulation might be of interest for predicting postsurgical recurrence of OSCC, but it remains unclear whether specific properties of the coagulome of OSCC are conducive to postsurgical recurrence. We examined this possibility using transcriptomic analyses of OSCC.Materials and methodsUsing bulk RNA-seq data from TCGA and other sources, we explored the link between the coagulome (n = 85 genes) and disease-free survival (DFS) of OSCC with machine-learning. Tumor microenvironment analyses and single-cell RNA-seq analyses were used to address the potential mechanisms that link coagulation and tumor recurrence. We also compared the coagulome of matched primary/recurrent OSCC.ResultsWe identified seven coagulation-related genes, either positively (F3, F2, F8 and PROC) or negatively (VWF, SERPING1, BDKRB2) linked to postsurgical recurrence in OSCC at low/intermediate risk, and we validated the model in an independent cohort. We examined their relationship with the tumor microenvironment, suggesting tumor infiltration by T cells as an element of mechanistic explanation. Increased expression of procoagulant genes, such as F3, was noted in recurrent compared to matched primary OSCC.ConclusionOur observations suggest that active coagulation shapes the oncological outcome of surgery. Analyzing the tumor procoagulant status might help predict postsurgical recurrence of OSCC.
Emotional intelligence training in health students: a pilot study
Authors: Dugué Manon , Sirost Olivier , Heutte Natacha , Dosseville Fabrice 
Published: February 2025

IntroductionThe aim of this study was to test the effectiveness of an emotional intelligence (EI) program based on the tripartite model, combining theory and practical physical activity for health training students.MethodThis pilot study was conducted with 68 students between October 2020 and October 2021. One group received the EI training intervention (n = 34) combining 8 h of theory and 10 h of practical exercises with physical activities on different EC based on scientific literature. While the other group served as a control group (n = 34) and received an intervention on a topic other than emotional intelligence (i.e., sociological approach to the body) during 18 h (n = 34) Participants of both groups were required to complete the trait EI questionnaire in the pre and post-test.ResultsResults showed a significant increase in emotion expression, emotion identification, stress management, emotional management, emotional abilities, sociability and emotional intelligence. No significant change was observed in the control group.DiscussionThese findings suggest that EI can be improved with physical activities and open possibilities to include EI program in health training program.
Enhancing soil microbial diversity, quality, and crop growth through deficit irrigation combined with biochar application
Authors: Zhang Ruxin , Qu Zhongyi , Wang Liping , Yang Wei , Zhang Dongliang , Zhao Yibo , Li Junjie 
Published: February 2025

IntroductionBiochar has been widely used under irrigation conditions because of its ability to improve agricultural soil productivity and crop yield. However, the effects of deficit irrigation biochar interactions on soil quality and underlying mechanisms remain not well understood.ObjectiveThis study aimed to determine whether deficit irrigation combined with biochar could interact with soil physics, chemistry, biology, and crop growth, thereby increasing the soil quality index and affecting crop yield and quality.MethodsIn this study, we conducted a 2-year experiment with differential irrigation: full irrigation (100% ETc) and deficit irrigation (60% ETc), applying three biochar doses (B0 = 0 t ha−1, B15 = 15 t ha−1, and B30 = 30 t ha−1).ResultsThe results showed that the biochar and irrigation interaction significantly affected soil enzyme activities, nutrients, and microbial biomass carbon and adenosine triphosphate contents, resulting in an increase in the number of dominant taxa and α diversity index in the biochar treatment under deficit irrigation conditions. However, this treatment resulted in lower relative abundances of Acidobacteria, Chloroflexi, and Candidatus Rokubacteria. Biochar application improved sunflower kernel quality, aboveground biomass, and yield, with varying effects under different irrigation practices. Compared with the other treatments, the B30 treatment under deficit irrigation conditions exhibited the highest aboveground biomass and yield, with increases of 1.3–28.3% and 1.1–33.5%, respectively. However, an increase in arginine and proline contents in the seeds was only observed later in the experiment. In addition, the soil quality index was crucial for sunflower yield, with its positive effects varying based on the irrigation method used.ConclusionBiochar applied under deficit irrigation was effective in improving soil environment and soil quality in the study area, at least for the 2-year pilot study. Most importantly, biochar counteracted the adverse effects of water deficit and promoted crop seed quality and yield.SignificanceIn conclusion, deficit irrigation combined with biochar application under conditions of water scarcity may be a novel approach for improving crop yield by reducing the negative effects of drought stress.
Different axis approaches for ultrasound-guided centrally inserted central catheterization in children: a systematic review and meta-analysis of randomized controlled trials
Authors: Lee In Kyung , Lee Kyeong Hun , Han Hye-ji , Choi Jieun , Kim Na Jin , Kim Kyunghoon 
Published: February 2025

BackgroundCentrally inserted central catheterization (CICC) is a critical procedure in pediatric care. However, CICC in children poses greater challenges compared to adults due to anatomical and physiological differences, leading to higher complication rates. Ultrasound-guided approaches have been developed to enhance the safety and effectiveness of CICC, but the comparative efficacy of different axis approaches remains unclear.MethodsA systematic review and meta-analysis of randomized controlled trials comparing different axis approaches for ultrasound-guided CICC in children was conducted. Searches were carried out in databases up to June 10, 2024. Six studies were included in the systematic review and three studies were included in the meta-analysis. Primary outcomes included first-attempt success rate, overall success rate, and cannulation time. Secondary outcomes were complications such as hematoma and posterior wall puncture.ResultsData from 547 children were analyzed. The long-axis in-plane approach significantly reduced cannulation time (MD −27.48 s, 95% CI, −33.99 to −20.97) and overall complications OR 0.21, 95% CI, 0.1–0.48) compared to short-axis out-of-plane approach. No significant differences were found in first-attempt or overall success rates between the long-axis and short-axis approaches.ConclusionThe long-axis approach for ultrasound-guided CICC in children offers significant advantages in reducing cannulation time and complications. While dynamic needle tip positioning method may serve as an alternative to in-plane methods, further studies are needed to validate its clinical efficacy. Further research is needed to refine these techniques and explore their application in diverse clinical settings.
Biochar and Plant Growth-Promoting Bacteria Boost Chemical and Biological Properties of Semiarid Soil in Cowpea
Authors: Araujo Inara da Silva , Martins Filho Argemiro Pereira , da Costa Diogo Paes , Silva Aline Oliveira , da França Rafaela Felix , Lira Junior Mario de Andrade , Duda Gustavo Pereira , Lima José Romualdo de Sousa , da Silva Mairon Moura , Araujo Ademir Sergio Ferreira , Hammecker Claude , Medeiros Erika Valente de 
Published: February 2025

Plant growth-promoting bacteria (PGPB) are an effective tool for improving nutrients in agricultural systems; however, their efficacy depends on successful colonization in soils. To address this challenge, biochar has been identified as an effective material for enhancing soil ecosystem services and can serve as a protective for PGPB. However, the impact of biochar and PGPB on soil health indicators and plant growth remains poorly understood. This study aimed to evaluate the effects of biochar and PGPB on soil chemical and biological properties in cowpea. We used biochar from bean husk (BHB) and grape fermentation residue (GFB) and Bradyrhizobium elkanii USDA 76 (BRA), Burkholderia cepacia ATCC 25416 (PRB), or Rhizobium altiplani BR10423 (RHI). BHB and PRB stimulated cowpea growth, while GFB and PRB promoted soil phosphatase activity. Overall, different combinations of biochar and PGPR increased soil pH, phosphorus, potassium, organic carbon content, and urease activity, but did not affect microbial biomass carbon and β-glucosidase activities. The biochars inoculated with the BRA showed the highest productivity. For example, plants subjected to the BRA + GFB treatment exhibited a 3.85-fold increase in productivity compared to the additional treatment that involved the use of commercial peat. The study demonstrated a positive effect of biochar and PGPB on soil enzymatic activity, nutrient content, and cowpea growth suggesting a sustainable alternative to chemical fertilizers, especially in poor soils. These findings highlight the potential of biochar as an environmentally sustainable carrier of PGPB while addressing the issue of agricultural waste reuse.
Perbandingan Metode Soxhletasi dan Perebusan untuk Isolasi Kafein dari Daun Teh
Authors: Huda Muhammad Badrul , Prayogo Fitra Adi 
Published: February 2025

Penelitian ini bertujuan untuk mengisolasi dan memurnikan kafein dari daun teh (Camellia sinensis) menggunakan dua metode ekstraksi: soxhletasi dan perebusan. Prinsip "like dissolves like" diterapkan dalam pemilihan pelarut untuk ekstraksi kafein. Kedua metode diikuti dengan kristalisasi dan rekristalisasi untuk meningkatkan kemurnian kafein yang diisolasi. Hasil penelitian menunjukkan perbedaan signifikan dalam rendemen dan kemurnian kafein yang diperoleh. Metode perebusan menghasilkan rendemen kafein sebesar 0,38% dengan titik leleh 235°C, mendekati nilai literatur untuk kafein murni (235-238°C). Sebaliknya, metode soxhletasi menghasilkan rendemen lebih rendah sebesar 0,008% dengan titik leleh 210°C, mengindikasikan kemurnian yang lebih rendah. Analisis visual kristal kafein juga menunjukkan perbedaan, dengan metode perebusan menghasilkan kristal putih-hijau dan metode soxhletasi menghasilkan kristal oranye-coklat. Penelitian ini menyoroti pentingnya pemilihan metode ekstraksi yang tepat untuk optimalisasi hasil dan kemurnian kafein dari daun teh, dengan implikasi signifikan untuk aplikasi dalam industri makanan, minuman, dan farmasi.
Kata kunci: Caffeine, Tea Leaves, Soxhlet Extraction, Boiling Method, Crystallization

ABSTRACT
This study aimed to isolate and purify caffeine from tea leaves (Camellia sinensis) using two extraction methods: soxhletation and boiling. The principle of "like dissolves like" was applied in selecting solvents for the extraction of caffeine, a nonpolar compound that is more soluble in organic solvents. Both methods were followed by crystallization and recrystallization to improve the purity of the isolated caffeine. The results showed significant differences in the yield and purity of the caffeine obtained. The boiling method produced a caffeine yield of 0.38% with a melting point of 235°C, close to the literature value for pure caffeine (235-238°C). In contrast, the soxhletation method produced a lower yield of 0.008% with a melting point of 210°C, indicating lower purity. Visual analysis of the caffeine crystals also showed differences, with the boiling method producing white-green crystals and the soxhletation method producing orange-brown crystals. This study highlights the importance of selecting an appropriate extraction method to optimize the yield and purity of caffeine from tea leaves, with significant implications for applications in the food, beverage and pharmaceutical industries.
Keywords: Caffeine, Tea Leaves, Soxhlet Extraction, Boiling Method, Crystallization
PENDAMPINGAN KEWIRAUSAHAAN SYARIAH SEBAGAI UPAYA MENCETAK SANTRIPRENEUR PONPES PUTRI MAMBAUL MA’ARIF DENANYAR JOMBANG
Authors: Sri Abidah Suryaningsih  , Khusnul Fikriyah  , Sjafiatul Mardliyah  , Fitriah Dwi Susilowati  , Erfania Dwi Putri Wakhidah  
Published: February 2025

Tujuan Pengabdian Kepada Masyarakat ini memberikan pendampingan kewirausahaan Syariah bagi santri, kegiatan pengabdian ini menjadi solusi bagi santri putri Pondok Pesantren Mambaul Maarif Asrama nur Khadijah 3 Jombang sebagai upaya meningkatkan pengetahuan dan ketrampilan bisnis sesuai dengan ajaran Islam, sehingga aktifitas atau muamalah yang dilakukan menjadi semakin berkah. kegiatan Pengabdian Kepada Masyarakat dilaksanakan sehari pada tanggal 19 Juli 2024 dengan metode workshop, sasaran kegiatan Pengabdian Kepada Masyarakat adalah 33 Santri putri dengan kriteria santri senior yaitu kelas XII SMA dan beberapa Mahasiswa. Hasil dari kegiatan Pengabdian Kepada Masyarakat menujukkan 1) respon positif terhadap kegiatan hal ini terlihat antusiasme para santri saat mengikuti acara baik pada saat menyimak materi maupun pada saat praktik pembuatan kue corncake. Sebanyak 69% santri berpendapat bahwa materi kewirausahaan Syariah sangat penting, dan sebanyak 63% setuju dan 36% sangat setuju bahwa kegiatan pendampingan kewirausahaan Syariah memotivasi santri menjadi santripreneur, 2) tingkat pemahaman santri terhadap materi kewirausahaan syariah, dapat diketahui melalui pre tes dan post tes terjadi peningkatan hasil pre test dengan post test dari 48% menjadi 90%.