bluuebunny/crossref_metadata_2025_split huggingface dataset:
The novelty of Sámuel Domby's medical dissertation
Authors: Kis Tímea N. 
Published: September 2023

AbstractSámuel Domby of Gálfalva (1729–1807) defended his doctoral dissertation De vino Tokaiensi at the University of Utrecht in 1758, and it was published in the same year. Domby was not the first medical student to write about the curative effects of the Tokaj-Hegyalja wines, but his book is really considered unique because he summarised and in many ways also exceeded the knowledge of earlier authors on the subject. He not only communicated what was known about the wines of Tokaj-Hegyalja, but also demonstrated through a series of medical, meteorological observations and chemical experiments why these wines were so excellent, what effects they had on a healthy human body and what ailments could be effectively treated by drinking them. In many respects, his work has stood the test of time: for instance his observations on the importance of terroir and the protection of origin are still worth considering today.
Treatment of oncological and hematological diseases in HIV infection
Authors: Lushchevich S. V. , Litvinov V. D. 
Published: September 2023

Oncological and hematological diseases associated with HIV infection continue to cause discussions among foreign and domestic researchers, clinicians, doctors, medical workers. The ongoing world globalization and modernization, environmental degradation have a detrimental effect on the health of citizens, which can be seen in virus mutations, high morbidity and a decrease in the social level in the Russian Federation and in the world. Oncological and hematological diseases associated with HIV infection are growing in the Russian Federation, but scientists do not stop at the results achieved, improving methods, treatment and therapy. As part of this study a statistical analysis of oncological and hematological diseases associated with HIV infection for 3 years (2019–2021) in Russia is carried out in order to trace the percentage of the medicine’s level, treatment’s effectiveness and deaths. A detailed analysis shows the decrease in deaths from HIV infection which pays attention the work of specialists in the Russian Federation. The purpose of this study is to identify a key method for the treatment of oncological and hematological diseases in HIV infection in Russia. The objective is to study the effectiveness of existing methods of treatment. Research methods – clinical, functional, microbiological and morphological.
Telomere length of various blood and bone marrow cells in patients with aplastic anemia
Authors: Luchkin A. V. , Mikhailova E. A. , Galtseva I. V. , Fidarova Z. T. , Abramova A. V. , Davydova Yu. O. , Kapranov N. M. , Nikiforova K. A. , Kulikov S. M. , Parovichnikova E. N. 
Published: September 2023

Background. Aplastic anemia proceeds with bone marrow failure and is associated with immunological suppression of normal blood stem cells’ proliferation, which lead to bone marrow aplasia. autoimmune aggression and internal defects of blood stem cell that cause abnormal hematopoiesis are being actively studied. An important role in the pathogenesis of the aplastic anemia is played by instability of telomere length (TL). determination of the initial TL makes it possible to clearly differentiate between the aplastic anemia and dyskeratosis congenita. also, it helps to identify the group of patients with short telomeres for prediction of therapy response. Aim. To investigation the TL of various blood and bone marrow cells in patients with aplastic anemia before treatment. Materials and methods. The group of patients with aplastic anemia was investigated (n = 45). blood donors (n = 32) and bone marrow donors (n = 10) of different ages were included in the reference group. adult patients with dyskeratosis congenita (n = 5) were included in the comparison group. Relative and absolute tl was identified in peripheral blood and bone marrow mononuclear cells, monocytes, lymphocytes by flow-FISH technique (combination of flow cytometry and fluorescence in situ hybridization). Results. Relative and absolute TL was comparable in different blood and bone marrow cells in patients with aplastic anemia before treatment. TL in peripheral blood and bone marrow mononuclear cells wasn’t significantly differed in groups of patients with aplastic anemia and healthy donors. Telomeres in patients with dyskeratosis congenita were identified as “ultrashort” and were significantly shorter than in patients with aplastic anemia. Conclusion. Determination of TL in patients with aplastic anemia is modern examination method, which is a necessary step of differential diagnosis between aplastic anemia and dyskeratosis congenita, which is the disease from group of constitutional bone marrow aplasia. It is preferred to identify the TL in adult patients with aplastic anemia by the flow-FISH. It is necessary to investigate the TL to predict treatment response and to identify risks of developing adverse experiences, which include relapse and clonal evolution.
PD-L1 and p53 expression in squamous cell carcinoma of the oropharynx depending on human papilloma virus status
Authors: Polatova D. Sh. , Madaminov A. Yu. , Savkin A. V. , Nurzhabov A. I. , Asamedinov N. K. , Ibragimova D. A. , Davletov R. R. , Nasirov S. K. 
Published: September 2023

Introduction. High-risk human papilloma virus (Hpv), especially genotype 16, causes oropharyngeal squamous cell carcinoma (OSCC). It is detected in about 70 % of tumors developing from lymphoid tissue of the tonsils or the base of the tongue. Due to the increased number of Hpv-positive OSCC, Hpv status is considered a marker of OSCC clinical outcome. Easy testing, low cost, reliability, and high sensitivity of immunohistochemical analysis for p16INk4a allowed to widely use this method for Hpv status determination.Aim. To determine the association between programmed death-ligand 1 (pD-L1) and p53 expression and presence of indirect Hpv marker – p16INk4a – in patients with OSCC.Materials and methods. The study included 76 patients with OSCC т1–4N0–3m0 who received treatment at the Republican Specialized Scientific and practical medical Center of Oncology and Radiology (n = 37) and its Tashkent branch (n = 39) between 2015 and 2020. for all selected patients, retrospective immunohistochemical analysis for the presence of p16INk4a, pD-L1 and р53 in tumor samples fixed with formalin in paraffin blocks was performed. In our work, immunohistochemical examination for p16INk4a was the only relevant tool for Hpv status determination. To reinforce its prognostic significance, we used additional molecular markers pD-L1 and p53 which play an important role in carcinogenic transformation and OSCC progression.Results. The results of immunohistochemical analysis showed that p16INk4a overexpression was accompanied by positive pD-L1 reaction in 46 % (6/13) of cases; there were no cases of positive expression of mutant type p53. wild type p53 was identified in only 1 (3 %) case in combination with p16INk4a overexpression.Conclusion. The developed panel consisting of 3 molecular markers (p16INk4a, pD-L1 and р53) may open new horizons in accurate prognosis, risk stratification and understanding of OSCC molecular signature. This, in turn, will help clinicians in selection of individual therapy strategies for treatment de-escalation and outcome optimization.
LESÃO DERMONECRÓTICA EM REGIÃO DORSAL EM UM CÃO: LESÕES COMPATÍVEIS COM LOXOSCELISMO
Authors: De Assis Santos Sílvia Vitória , De Gouveia Ribeiro Junior Carlos Roberto , Dos Santos Sandra Batista , Soares dos Santos José Rômulo , Cordão Maiza Araújo , Carneiro Arthur Nóbrega 
Published: September 2023

O loxoscelismo é o quadro clínico causado pela picada de aranhas do gênero loxosceles, o qual pode apresentar-se de duas formas distintas, cutânea e cutâneo-visceral, cuja incidência varia de 84% a 97% e 3% a 16%, respectivamente. A forma cutânea é caracterizada por alterações clínicas locais, mediante o aparecimento de uma lesão inflamatória no local da picada, com presença de edema. Já a forma cutâneo-visceral é caracterizada por alterações sistêmicas, como a insuficiência renal aguda e distúrbios de coagulação sanguínea, sendo essa a forma mais letal e passível a óbito. O presente trabalho objetiva relatar um caso de tratamento de dermonecrose, após provável picada da aranha marrom e avaliar a eficiência da terapêutica adotada. O atendimento ocorreu em uma clínica veterinária localizada no município de Goiana, no estado de Pernambuco. Um cão, fêmea, da raça Poodle apresentou uma lesão eritematosa de início agudo na região dorsal com presença de edema e área necrótica associado a um abscesso fistulado, de aspecto semelhante à lesão do loxoscelismo cutâneo. O tratamento consistiu na administração de omeprazol (Gaviz-V® 10mg/Kg), cefalexina (Petsporin® 300mg/Kg) e meloxicam (Meloxinew® 0,5mg/Kg) por via oral como tratamento sistêmico e limpeza com soro fisiológico e compressas com Kollagenase® para tratamento tópico. Após 12 dias de tratamento o animal apresentava uma melhora satisfatória. O quadro clínico do presente estudo foi compatível com acidente por aranhas do gênero loxosceles spp. e o tratamento mostrou-se eficiente para a redução da lesão dermonecrótica.
Tek taraflı pseudoeksfolyasyon materyali olan glokomlu ve hastalıksız bireylerin, optik koherens tomografi-anjiografi cihazı ile makula değerlendirmesi
Authors: YÜKSEL ELGİN Cansu 
Published: September 2023

Amaç: Tek taraflı pseudoekfolyasyon materyali (XFM) izlenen bireylerin; glokom geliştiği ve gelişmediği durumlarda makula vasküler yoğunluğunun gözler arası değişimini gözlemlemek.
Gereç ve yöntemler: 38 sayıda tek taraflı pseudoeksfolyasyon sendromlu (XFS) bireyin 76 gözü ve 36 sayıda tek taraflı pseudoeksfolyasyon glokomlu (XFG) hastanın 72 gözü çalışmaya dahil edilmiştir. Her iki grubun XFM olan ve olmayan gözlerinin OCT-A ile incelenen tüm makuler belirteçleri standart ortalama karşılaştırmalı t testi ile değerlendirilmiştir. Her iki gruptaki XFM pozitif ve negatif olan göz grupları birbirleriyle ve gruplar arasında Kruskal-Wallis testi ile kıyaslanmıştır.
Bulgular : Tek taraflı XFS olan hastaların gözler arası yüzeyel kapiller pleksus yoğunluğunda anlamlı farklılıklar minimal görülürken tek taraflı XFG’lerin gözler arası makulanın totalinde (p= 0,0004) üst ve alt yarımında (p=0.0018, p=0.0002), fovea (p=0,014), parafovea (p=0,0411) ,parafoveanın inferior yarımı (p=0,0126) ve temporalinde (p=0,0126); glokomlu gözlerde anlamlı düzeyde damar yoğunluğunda azalma dikkati çekmektedir. Derin kapiller pleksusta ise hem grup içi hem gruplar arası kıyaslamalarda anlamlılık, yüzeyel damar tabakasına göre azalmıştır.
Sonuç: Medikal tedaviyle kontrol edilen glokom tablolarında makula bölgesindeki özellikle yüzeyel kapiller pleksusun yoğunluğunda azalma olduğu gösterilmiştir. Ancak bu damarsal azalma glokomsuz gözlerde XFM varlığında öncü bulgu olarak gösterilememiştir.
Lembaga Peradilan Khusus Pemilu Di Indonesia dalam Perspektif Hukum Tata Negara
Authors: Muni Abd Muni 
Published: September 2023

Negara Indonesia menganut sistem demokrasi dengan mengedepankan suara rakyat, tak pernah lepas dari suksesi kepemimpinan melalui pemilu. Pesta demokrasi di Indonesia dinaungi oleh sebuah lembaga yang bernama BAWASLU (Badan Pengawasan Pemilu). Salah satu kewenangan BAWASLU adalah mengawasi dan menyelesaikan pelanggaran dan sengketa Pemilu. Namun dalam hal ini dapat dimengerti ada dua kewenangan yang dimiliki oleh BAWASLU yakni mengawasi dan juga menyelesaikan sengketa pemilu.
Tulisan ini akan membahas tentang dua kewenangan yang dimiliki bawaslu tersebut apakah sudah memenuhi asas-asas penyelenggara pemilu, salah satunya jika dikaitkan dengan asas profesionalitas dan akuntabilitas. Selanjutnya ditinjau dari perspektif ius constituendum ada dua istilah yang harus dipahami lebih lanjut yakni electoral board dan electoral court. KPU dan Bawaslu sendiri pada dasarnya termasuk kedalam electoral board, sementara yang harus dipertegas disini adalah lembaga yang dikhususkan untuk menyelesaikan pelanggaran dan sengketa pemilu secara akuntabel dan profesional. Electoral Court adalah lembaga baru yang dibuat berjenjang mengikuti jenjang struktur KPU dan Bawaslu. Lembaga Peradilan Khusus Pemilu bertujuan untuk menangani pelanggaran dan sengketa kepemiluan diluar struktur Kekuasaan Kehakiman konvensional.
Proposta de Pesquisa Científica para Avaliação da Segurança Microbiológica de Queijos Artesanais fabricados com leite cru e maturados por período inferior a 60 dias produzidos no estado de São Paulo
Authors: Pinto Uelinton , Telles Evelise Oliveira , Campos Gabriela Zampieri , Medeiros Mariana Medina , Kunigk Cynthia Jurkiewicz , Baptista Débora Parra , Pimentel Filho Natan de Jesus , Lacorte Gustavo Augusto , Badaró Andréa Cátia Leal , Rosenfeld Andrea Mello Franco , Souza Andreza Oliveira de , Ribeiro Alessandra Casagrande , Tribst Alline Artigiani Lima 
Published: September 2023

Introdução: No Brasil, a legislação exige maturação mínima de 60 dias para queijos produzidos com leite cru, salvo se houver comprovação científica de que a redução do prazo não compromete a segurança do produto, como ocorreu com alguns queijos artesanais tradicionais de diferentes regiões do estado de Minas Gerais. No estado de São Paulo, onde os produtores seguem formulações e processos específicos individuais, a falta de um padrão de pesquisa validado dificulta a avaliação da segurança microbiológica deste tipo de queijo, pois essas pesquisas são dispendiosas e não há garantia de que os parâmetros estabelecidos pelos pesquisadores seriam aceitos pelos serviços de inspeção. Objetivo: Para abordar este desafio, esta proposta visa estabelecer um modelo de pesquisa científica padronizado para avaliar a segurança de queijos de leite cru maturados por menos de 60 dias. Métodos: Com base na proposta do DIPOA para classificação de Risco de Estabelecimentos, foi criado um checklist para classificação dos estabelecimentos/produtos, considerando risco do produto, volume processado e características de desempenho do estabelecimento em relação às Boas Práticas de Fabricação. Resultados: A pontuação obtida pela aplicação do checklist na produção do queijo em questão determina o risco do produto como baixo, médio, alto ou muito alto e auxilia no estabelecimento do número mínimo de amostras a serem avaliadas mensalmente. Discussão: Espera-se que essa pesquisa auxilie produtores e órgãos de registro, fiscalização e inspeção no processo de legalização dos queijos artesanais de leite cru, possibilitando o desenvolvimento rural e a fixação de mão de obra no campo.
MĀORI EXPERT VIEWS OF ANTIMICROBIAL RESISTANCE USING A ONE HEALTH APPROACH: A QUALITATIVE STUDY
Authors:   University of Otago, Carrington Samuel D. , Norris Pauline ,   University of Otago, Priest Patricia ,   University of Otago, Wyeth Emma H. ,   University of Otago
Published: September 2023

Māori experience disproportionately worse outcomes from infectious diseases compared to non-Māori, and antimicrobial resistance (AMR) contributes to these inequities. The aim of the study reported in this article was to gain insight into Māori experts’ perspectives on AMR using a One Health approach, which incorporates understandings of human, animal and environmental health. Qualitative methods were applied and were guided by principles of Kaupapa Māori research. Four themes were identified: (1) the importance of AMR education for Māori, (2) the connection of mātauranga Māori and AMR, (3) colonisation and its negative impacts on hauora Māori and (4) collaboration across spheres of health as a priority for Māori. Overall, the findings show a need for greater recognition of an approach to AMR that is grounded in te ao Māori. This focus should be a priority for government agencies and healthcare providers across Aotearoa New Zealand in order to work towards health equity for Māori in tackling AMR.
Essential neural anatomy for creating a clinically translatable osseointegrated neural interface for prosthetic control in sheep
Authors: Gunderson Kirsten A. , Odorico Scott K. , Nkana Zeeda H. , Sears Lucas , Seils Grant , Minor Rashea L. , Zeng Weifeng , Poore Samuel O. , Dingle Aaron M. 
Published: September 2023

Aim: Ovine models for osseointegrated prosthetics research are well established, but do not consider neural control of advanced prostheses. The validity of interfacing technologies, such as the Osseointegrated Neural Interface (ONI), in their ability to provide communication between native nerves and advanced prosthetics is required, necessitating a stable, longitudinal large animal model for testing. The objective of this study is to provide a detailed anatomic description of the major nerves distal to the carpal and tarsal joints, informing the creation of a chronic ONI for prosthetic control in sheep.
Methods: Six pelvic and six thoracic cadaveric limbs from mature female, non-lactating sheep were utilized. Radiographs were obtained to determine average bone length, medullary canal diameter, and cortical bone thickness. Microsurgical dissection was performed to discern topographical neuroanatomy and average circumferences of the major nerves of the pelvic and thoracic limbs. Histologic analysis was performed. A surgical approach for the creation of ONI was designed.
Results: Average metacarpal and metatarsal length was 15.0 cm (± 0.0) and 19.7 cm (± 1.0), respectively. Average intramedullary canal diameter was 12.91 mm (± 3.69) for forelimbs and 12.60 mm (± 3.69) for hindlimbs. The thoracic limb nerves consisted of one dorsal and three ventral nerves, with an average circumference of 5.14 mm (± 2.00) and 5.05 mm (± 1.06), respectively. Pelvic limb nerves consisted of two dorsal and one ventral nerve with an average circumference of 6.27 mm (± 1.79) and 5.40 mm (± 0.53), respectively.
Conclusions: These anatomic data inform the surgical approach and manufacture of a sensory ONI for chronic testing in awake, freely ambulating animals for future clinical translation.
Unveiling the structural evolution of oxide surface in liquid water
Authors: Liu Wei-Tao , Li Xiaoqun , Brigiano Flavio S. , Pezzotti Simone , Liu Xinyi , Chen Wanlin , Chen Huiling , Li Ying , Li Hui , Shen Yuen-Ron , GAIGEOT Marie-Pierre 
Published: September 2023

Abstract

Aqueous interfaces of oxides are ubiquitous on our planet, playing a key role in the ecosphere1: for example, protonation/deprotonation of silicates in water dominates the weathering process that shapes the Earth landscape, and serves as the major sink in global carbon cycle2. In modern industrial applications, oxide/water interfaces also host many important reactions, such as the oxygen evolution in renewable energy schemes3. However, accurate knowledge about these interfaces still lacks at the molecular level, due to difficulties in accessing buried oxide surfaces4,5. Here we report an experimental scheme enabling in situ vibrational spectroscopy of oxide surfaces in liquid water. Application to the silicon oxide/water interface revealed surprisingly the emergence of new pathways from reactions with water. With ab initio molecular dynamics and metadynamics simulations, we uncovered a surface reconstruction, triggered by deprotonation of surface hydroxylated groups, that led to unconventional five-coordinated silicon species. The result demystifies the multimodal chemistry of aqueous silica discovered decades ago, bringing in new information that will radically modify our current understanding. Most exciting of all, our study provides new opportunities for future in-depth physical and chemical characterizations of all oxide/water interfaces.
Prednisolone Versus Colchicine for Acute Gout in Primary Care (COPAGO). Protocol for a two-arm multicentre, pragmatic, prospective, randomised, double-blind, controlled clinical trial of prednisolone and colchicine for non-inferiority with a parallel group design.
Authors: Truthmann Julia , Pereira Julia Freyer Martins , Richter Adrian , Schuster Franziska , Witte Amelie , Böhm Susanne , Greser Alexandra , Kamin Petra , Stracke Sylvia , Dörr Marcus , Bülow Robin , Engeli Stefan , Gágyor Ildikó , Hummers Eva , Chenot Jean-François 
Published: September 2023

Abstract
Background: Gout is the most common form of rheumatic disease in which monosodium urate crystals are deposited in the joints followed by acute inflammatory reactions. There are various approved drugs that can be prescribed for pain relief during an acute gout attack. However, to date, no direct comparison of efficacy of colchicine and prednisolone for the treatment of acute gout attacks has been investigated. Furthermore, the majority of previous research studies were not only conducted in tertiary centres but also excluded patients with common comorbidities due to contraindications to naproxen.
Methods: This pragmatic, prospective, double-blind, double-dummy, parallel-group, randomized, non-inferiority trial investigates whether prednisolone (intervention) is non-inferior to treatment with colchicine (active control) in patients with acute gout. Adult patients presenting with acute gout to their general practitioners in 60 practices across 3 university sites (Greifswald, Göttingen, and Würzburg) are eligible to participate in the study. Participants in the intervention group receive 30 mg prednisolone for 5 days. Those in the control group receive low-dose colchicine (day 1: 1.5 mg; day 2-5: 1 mg). The primary outcome is the absolute level of the most severe pain on day 3 (in the last 24 hours) measured with an 11-item numerical rating scale. Day 0 is the day patients take their study medication for the first time. They are then asked to fill out a study diary the same time each day for pain quantification. Pain scores are used for comparison between the two medications. Secondary outcomes are average response to treatment, swelling, tenderness and physical function of the joint, patients' global assessment of treatment success, use of additional pain medication and non-pharmacological pain therapies. For safety reasons potential side effects and course of systolic blood pressure are assessed.
Discussion: This trial will provide evidence on the effectiveness of pain reduction and side effects of colchicine and prednisolone in acute gout in primary care.
Trial registration: ClinicalTrials.gov Identifier: NCT05698680 first posted on January 26, 2023 (retrospectively registered). URL of trial registry record: https://clinicaltrials.gov/study/NCT05698680