bluuebunny/crossref_metadata_2025_split huggingface dataset:
Real World Efficacy and Safety of Sofosbuvir + Velpatasvir + Voxilaprevir in Romanian Patients with Genotype 1b HCV Infection Non-reponders to DAAs Therapy
Authors: Gheorghe Liana , Preda Carmen , Trifan Anca , Manuc Mircea , Stanciu Carol , Istratescu Doina , Popescu Corneliu Petru , Diculescu Mircea Mihai , Tieranu Cristian George , Manuc Teodora , Stroie Tudor Gheorghe , Iacob Speranta Maria , Iliescu Laura 
Published: December 2022

Background and Aims: The sofosbuvir (SOF) / velpatasvir (VEL) / voxilaprevir (VOX) combination has been evaluated in more than 800 patients enrolled in phase II and phase III studies, where it demonstrated excellent safety and efficacy, achieving overall sustained viral response (SVR) rates of more than 95%. We aimed to assess the efficacy and safety of SOF/VEL/VOX in a real-world study, including patients previously treated for genotype 1b hepatitis C virus (HCV) infection that did not obtain a sustained viral response with previous direct‐acting antivirals (DAAs) therapy.
Methods: In Romania, through a nationwide government-funded program in 2019-2020, 213 patients with chronic hepatitis C non-responders to previous DAAs therapy, received treatment with SOF/VEL/ VOX 400/100/100 mg/day for 12 weeks. We performed a retrospective longitudinal study that included 143 individuals who were treated in Bucharest, Iași, Craiova and Constanța clinics, all with genotype 1b HCV infection. Efficacy was assessed by the percentage of patients achieving SVR 12 weeks post-treatment (SVR12). Serious adverse events (SAE) were registered.
Results: Our cohort comprised 53% males with a median age of 60 years (27÷77); 47% were pre-treated with ombitasvir/paritaprevir/ritonavir+dasabuvir ± ribavirin, 40% with ledipasvir/SOF, 13% with elbasvir/ grazoprevir. 42% of patients associated co-morbidities, 45% had compensated liver cirrhosis, 2% had treated hepatocellular carcinoma (HCC) and 1% had hepatitis B virus co-infection. SVR by intention to treat was reported in 139/143 (97.2%) and per protocol in 141/143 (98.6%). No predictive factors for SVR were identified. Rate of liver decompensation in patients with cirrhosis was 6% and was statistically associated in multivariate analysis with Child-Pugh score (p<0.01) and with severe steatosis (p=0.004). Occurrence of new HCC was reported in 3.6% of all patients with cirrhosis and was associated with poor liver function [higher Child-Pugh score (p=0.001) and low albumin levels (p=0.02)]. Serious adverse events related to therapy were reported in 1/143(0.7%).
Conclusions: SOF/VEL/VOX was highly efficient in our population of patients with a 97.2% SVR. Liver decompensation occurred in 6% of cirrhotic patients at SVR, related to hepatic dysfunction.
Sedation for Endoscopic Retrograde Cholangiopancreatography in Elderly Patients – the Effect of Intravenous Lidocaine Infusion. A Randomised, Double-Blind, Placebo Controlled Trial
Authors: Breazu Caius Mihai , Alexa Alexandru Leonard , Urs Oana , Mercea Voicu , Tantau Marcel , Bartos Adrian , Ciobanu Lidia , Ionescu Daniela 
Published: December 2022

Background: Sedation of elderly patients with associated comorbidities, subjected to ERCP procedure, can produce serious complications including respiratory instability and hemodynamics caused by the administration of anesthetic substances. In this study we aimed to evaluate whether the administration of lidocaine in continuous infusion during ERCP procedure reduces the consumption of propofol and the rate of complications in these patients.
Methods: 83 patients over 65-year old, ASA II-IV score, undergoing an ERCP procedure were randomized in two groups: lidocaine group (group L) who received 1.5 mg/kg lidocaine 1% and propofol 1mg/kg at induction and then 2 mg/kg lidocaine 1% in continuous infusion during the procedure and control group (group C) who received saline in the same amount as group L and propofol 1mg/kg. The consumption of propofol, intraprocedural complications, the time of awakening and recovery, the quality of postprocedural analgesia, the satisfaction of the endoscopist were registered.
Results: Propofol consumption was statistically significantly lower in group L compared to group C [135.37 (±43.23) vs. 214.88 (±51.83), p=0.001]. The same result was obtained related to the awakening time [2.85 (±1.50) vs. 5.38 (±1.36), p=0.001] and recovery time [23.90 (±12.66) vs. 26.17 (±12.41), p<0.001], the episodes of intraprocedural desaturation (p=0.001), the involuntary intraprocedural movements (p=0.001), the endoscopist‘s satisfaction (p=0.006). No differences were found in terms of post-procedure pain scores (p=0.54).
Conclusions: Lidocaine can be administered to reduce the need for propofol, faster awakening and lower intraprocedural complications in elderly patients undergoing the ERCP procedure.
Acceptability of Hybrid Endoscopic Submucosal Dissection Using Multifunctional Snare for Small-sized Gastric Neoplasms: A Prospective Observational Study
Authors: Chiyo Taiga , Kobara Hideki , Nishiyama Noriko , Nakatani Kaho , Tada Naoya , Koduka Kazuhiro , Matsui Takanori , Kobayashi Nobuya , Fujihara Shintaro , Yachida Tatsuo , Masaki Tsutomu 
Published: December 2022

Background and Aims: The most suitable procedure for resecting small-sized gastric neoplasms remains unclear. Endoscopic mucosal resection leads to non-curative resection owing to slippage of the snare, and technically difficult endoscopic submucosal dissection (ESD) is instrumentally uneconomical. A novel, cost-effective, multifunctional snare called SOUTEN is available as a hybrid ESD (h-ESD) device developed for facilitating ESD. This study aimed to assess the acceptability of h-ESD using the SOUTEN for resecting small-sized gastric neoplasms.
Methods: This was a prospective observational study conducted at our single institution between March 2019 and March 2021. Fifty-seven consecutive patients who underwent h-ESD using SOUTEN for small-sized gastric neoplasms ≤15 mm involving adenoma and tubular-type mucosal carcinoma without ulceration were enrolled. The primary outcome was curative resection rate for h-ESD. Secondary outcomes were the rates of conversion to ESD, rate of total (h-ESD + ESD) curative resection, procedure time, rates of intra-and post- operative complications, and presence of additional knives excluding hemostatic forceps.
Results: The curative resection rate of h-ESD was 89.5% (51/57). The total (h-ESD + ESD) curative resection rate was 94.7% (54/57). The mean procedure time was 21.2 (±16.5) minutes. One case of delayed bleeding occurred. Additional knives were applied in two cases.
Conclusions: The cost-efficient h-ESD using SOUTEN can be an acceptable procedure for resecting small- sized gastric neoplasms.
Automatic Diagnosis of High-Resolution Esophageal Manometry Using Artificial Intelligence
Authors: Popa Stefan Lucian , Surdea-Blaga Teodora , Dumitrascu Dan Lucian , Chiarioni Giuseppe , Savarino Edoardo , David Liliana , Ismaiel Abdulrahman , Leucuta Daniel Corneliu , Zsigmond Imre , Sebestyen Gheorghe , Hangan Anca , Czako Zoltan 
Published: December 2022

Background and Aims: High-resolution esophageal manometry (HREM) is the gold standard procedure used for the diagnosis of esophageal motility disorders (EMD). Artificial intelligence (AI) might provide an efficient solution for the automatic diagnosis of EMD by improving the subjective interpretation of HREM images. The aim of our study was to develop an AI-based system, using neural networks, for the automatic diagnosis of HREM images, based on one wet swallow raw image.
Methods: In the first phase of the study, the manometry recordings of our patients were retrospectively analyzed by three experienced gastroenterologists, to verify and confirm the correct diagnosis. In the second phase of the study raw images were used to train an artificial neural network. We selected only those tracings with ten test swallows that were available for analysis, including a total of 1570 images. We had 10 diagnosis categories, as follows: normal, type I achalasia, type II achalasia, type III achalasia, esophago-gastric junction outflow obstruction, jackhammer oesophagus, absent contractility, distal esophageal spasm, ineffective esophageal motility, and fragmented peristalsis, based on Chicago classification v3.0 for EMDs.
Results: The raw images were cropped, binarized, and automatically divided in 3 parts: training, testing, validation. We used Inception V3 CNN model, pre-trained on ImageNet. We developed a custom classification layer, that allowed the CNN to classify each wet swallow image from the HREM system into one of the diagnosis categories mentioned above. Our algorithm was highly accurate, with an overall precision of more than 93%.
Conclusion: Our neural network approach using HREM images resulted in a high accuracy automatic diagnosis of EMDs.
The Risk of Postpolypectomy Bleeding in Patients Receiving Direct Oral Anticoagulants compared to Warfarin or Nonanticoagulation: A Systematic Review with Meta-Analysis
Authors: Ye Hao-zhen , Wang Ben , Zhou He , Gao Jia-jia , Li Zhi-Wei , Xu Hong-wei 
Published: December 2022

Aim: The aim of our systematic review and meta-analysis was to assess the risk of postpolypectomy bleeding (PPB) in patients exposed to direct oral anticoagulants (DOACs).
Methods: A systematic search was conducted by searching the PubMed, Embase, and Cochrane Library databases using the following search terms: “(nonvitamin K antagonist oral anticoagulants or NOAC or apixaban or dabigatran or rivaroxaban or edoxaban or DOAC or direct oral anticoagulants) and polypectomy”. Studies evaluating the association between DOACs and PPB were identified.
Results: The bibliographical search yielded 103 studies. Twelve studies involving 621,279 participants were ultimately included (11 cohort studies, of which 10 were retrospective, and a randomized controlled trial.). Pooled estimates revealed a higher risk of PPB among patients using DOACs than among those without anticoagulation (odds ratio [OR]: 6.170, 95% confidence interval [CI]: 3.079 to 12.363). The same result occurred when DOACs were stopped 24 hours before polypectomy (OR: 8.66, 95% CI: 4.588 to 16.348). No significant difference was noted between overall DOACs and warfarin (OR 0.826, 95% CI 0.583 to 1.172), while for subgroups, dabigatran showed a lower PPB rate than warfarin (OR: 0.582, 95% CI: 0.340 to 0.994).
Conclusions: DOACs can significantly raise the risk of PPB, even with 24-hour withdrawal before polypectomy. In addition, a lower risk of PPB was detected for dabigatran than for warfarin.
The Role of Educational Psychology for Teachers in Learning Effectiveness
Authors: Azura Yuni , Tarsono Tarsono , Hermawan A. Heris , Ningsih Arum 
Published: December 2022

This study is blackfaced with problems in learning processes, such as teachers do not understand the student's situation and condition, they apply incorrect methods, or the learning process tends boring. The important role of psychological education for teachers is to help them understand students' psychological aspects so that teachers have basic rules for applying effective learning techniques to particular student characteristics. This study aims to know the essential role of psychology for teachers in the learning process and the psychological scope for teachers in studying students. The study uses qualitative methods, which isa literature approach (library research). Researchers use documentaries to collect data. This study shows that teachers must study educational psychology. In educational psychology, there is much discussion of the problems associated with human development. So, as an educator, it is very important to understand educational psychology.Penelitian ini dilatar belakangi dengan adanya masalah dalam proses pembelajaran seperti guru tidak memahami situasi dan kondisi siswa, penerapan metode yang kurang tepat dan proses pembelajaran cenderung membosankan. Peran penting pembelajaran psikologi pendidikan bagi guru membantu dalam mempelajari aspek psikologis siswa agar guru memiliki aturan dasar untuk menerapkan teknik pembelajaran yang efektif yang diterapkan pada karakteristik siswa tertentu. Penelitian ini bertujuan untuk mengetahui peranan penting psikologi bagi guru dalam proses pembelajaran dan mengetahui ruang lingkup psikologi bagi guru dalam mempelajari siswa. Penelitian ini menggunakan metode kualitatif dengan jenis pendekatankepustakaan (Library Research). Peneliti menggunakan studi dokumenter untuk pengumpulan data dalam penelitian. Hasil penelitian ini menunjukan bahwa sangat penting bagi guru dalam mempelajari psikologi pendidikan. Dalam psikologi pendidikan, banyak sekali pembahasan tentang masalah-masalah yang berkaitan dengan perkembangan manusia. Sehingga, sebagai pendidik sangat penting memahami psikologi pendidikan.
A Curriculum Analysis of the Moral Creed: the Pattern of Moral Formation
Authors: Hidayat Fitria , Wahidah Nida Fatmah , Mulyadi Yadi 
Published: December 2022

The Moral Creed curriculum in SMPN 1 of the west Bandung district contains various subject materials that point to achieving noble character in daily life, such as doing dhuha prayer, reading asmaul husna, and reading the Qur'an. Although the curriculum has been adopted based on the 2015 article 1 rule dictating to students no. 23, there are problems, such as declining student morals, students still not being used to recitation, and even cannot do it. The study aims to analyze the Moral Creed curriculum in the central west Bandung district. This study is quantitative research using the library research method. The primary data is through interviews, and secondary data is through books and other support sources. The data analysis used is analysis content. This study suggests that the Moral Creed curriculum at SMPN 1 should develop the curriculum to humanize humans and require a proper education method in the learning process.Kurikulum Akidah Akhlak di SMPN 1 Porongpong Kabupaten Bandung Barat memuat berbagai materi pelajaran yang mengarahkan pada tercaIslamic Educationnya akhlak mulia dalam kehidupan sehari-hari seperti mengerjakan sholat dhuha, membaca asmaul husna, dan membaca al-Qur’an. Meskipun sudah diterapkan kurikulum sesuai dengan peraturan Mendikbud RI No 23 Tahun 2015 Pasal 1, terdapat beberapa masalah seperti menurunnya akhlak siswa dan siswa masih belum terbiasa mengaji bahkan ada siswa yang tidak bisa mengaji. Penelitian ini bertujuan untuk menganalisis kurikulum akhlak di SMPN 1 Paronpong Kabupaten Bandung Barat Indonesia. Jenis penelitian ini termasuk penelitian kuantitatif dengan menggunakan metode library reseach, sumber data dalam penelitian ini yaitu sumber data primer melalui wawancara dan data sekunder melalui buku serta sumber pendukung lainnya. Analisis data yang digunakan yaitu konten analisis. Hasil penelitian ini menunjukan bahwa kurikulum akidah akhlak di SMPN 1 Porongpong mengembangkan kurikulum untuk memanusiakan manusia, untuk mewujudkan hal tersebut dibutuhkan metode pendidikan yang tepat dalam proses pembelajaran.
Instillation of Prayer Values in Nature Shaping Students' Personalities
Authors: Nuryana Ari , Suhartini Andewi , Basri Hasan 
Published: December 2022

Efforts made by educators in shaping the personality of good students have been carried out but have not produced maximum results. This study aims to identify the cultivation of prayer values This research uses a qualitative approach with a case study method. The results of the study show that: 1) the values of prayer that are instilled are religious values, such as being obedient to worship & loving cleanliness. Moral values, such as honesty, discipline, responsibility are not arrogant & polite. Social values, such as empathy & tolerance; 2) the process of inculcating the values of prayer is carried out in three stages, namely value transformation through PAI learning in class, value transactions through material appreciation & trans internalization of values through habituation programs; 3) the material used is PAI material related to fiqh; 4) the methods used are habituation of prayer, habituation of recitations of the Qur'an, habituation of Asmaul Husna, habituation of greeting in the morning, habituation of GPS & honesty stalls; 5) evaluation is carried out on the achievement of student personality using attitude assessment which results in prayer worship can shape the student's personality; 6) supporting factors for inculcating the values of prayer, namely the existence of worship facilities, school policies and partnerships with parents. While the inhibiting factors are less supervision from parents & a less supportive living environment.Ikthiar yang dilakukan oleh pendidik dalam membentuk kepribadian siswa yang baik telah dilakukan akan tetapi belum membuahkan hasil yang maksimal.Penelitian ini bertujuan untuk mengidentifikasi penanaman nilai-nilai sholat . Penelitian ini menggunakan pendekatan kualitatif dengan metode studi kasus. Hasil penelitian menunjukkan bahwa 1) nilai-nilai ibadah shalat yang ditanamkan yaitu nilai religius, seperti taat beribadah & cinta kebersihan. Nilai moral, seperti jujur, disiplin, tanggungjawab, tidak sombong & sopan santun. Nilai sosial, seperti empati & toleransi; 2) proses penanaman nilai-nilai ibadah shalat dilakukan melalui tiga tahap, yaitu tranformasi nilai melalui pembelajaran PAI di kelas, transaksi nilai melalui penghayatan materi & trans internalisasi nilai melalui program pembiasaan; 3) materi yang dipakai adalah materi PAI yang berkaitan dengan fikih; 4) metode yang digunakan yaitu pembiasaan shalat, pembiasaan tilawah al-Qur’an, pembiasaan asmaul husna, pembiasaan sapa pagi, pembiasaan GPS & warung kejujuran; 5) evaluasi dilakukan pada hasil capaian kepribadian siswa menggunakan penilaian sikap yang hasilnya ibadah shalat dapat membentuk kepribadian siswa; 6) faktor pendukung penanaman nilai-nilai ibadah shalat yaitu adanya sarana ibadah, kebijakan sekolah dan kemitraan dengan orangtua. Sedangkan faktor penghambatnya yaitu pengawasan yang kurang dari orangtua & lingkungan tempat tinggal yang kurang mendukung.
The Creativity of Islamic Religious Education Teachers for Effective Learning
Authors: Fauzan Farhan Ahmad , Hasbiyallah Hasbiyallah , Fikri Miftahul 
Published: December 2022

Learning in schools currently cannot be effective due to the lack of organized learning by the teacher. This study was to determine the effect of the creativity of Islamic Religious Education teachers in Elementary Schools or Madrasah Ibtidaiyah on effective learning. The research method is a quantitative method with a post-positivist approach. The population in this study was 25 teachers of Islamic education at the Elementary School or Madrasah Ibtidaiyah in the city of Bandung. While the sample is 18 teachers. Data collection through questionnaires. The data analysis technique used data normality test and correlation test. Hypothesis testing using a path analysis of 0.05. The results of the normality test of the data showed that the data were normally distributed, which was indicated by the distribution of the points on the Q-Q diagram on a diagonal line in both the teacher creativity test and effective learning. The results of the correlation test show that there is a positive relationship between teacher creativity in realizing effective learning with a coefficient of 0.522. The conclusion from the results of this study is that there is an influence of teacher creativity in an effort to realize effective learning. So the more Islamic Religious Education teachers increase their creativity, the higher the chances of realizing effective learning.Pembelajaran di sekolah saat ini belum bisa efektif dikarenakan kurang terorganisirnya pembelajaran oleh Guru.Penelitian ini bertujuan untuk mengetahui pengaruh kreativitas guru Pendidikan Agama Islam di Sekolah Dasar/ Madrasah Ibtidaiyah terhadap pembelajaran efektif. Metode penelitian ini adalah metode kuantitatif dengan pendekatan post-positivisme. Populasi dalam penelitian ini adalah 25 orang guru pendidikan Agama Islam di Sekolah Dasar atau Madrasah Ibtidaiyah di Kota Bandung. Sedangkan sampel nya adalah 18 guru. Pengumpulan data melalui angket. Teknik analisis data menggunakan uji normalitas data dan uji kolerasi. Pengujian hipotesis menggunakan analisis jalur 0,05. Hasil penelitian uji normalitas data menunjukkan data yang berdistribusi normal yang ditujukkan oleh sebaran titik-titik pada diagram Q-Q berada pada garis diagonal baik pada uji kreativitas guru maupun pembelajaran efektif. Hasil uji kolerasi menunjukan terdapat hubungan yang positif antara kreativitas guru terhadap pembelajaran efektif dengan koefesien sebesar 0,522. Kesimpulan dari hasil penelitian ini adalah terdapat pengaruh kreativitas guru dalam usaha mewujudkan pembelajaran efektif. Maka semakin guru Pendidikan Agama Islam meningkatkan kreativitas nya, semakin tinggi peluang untuk mewujudkan pembelajaran yang efektif.
An overview of dentin conditioning and its effect on bond strength
Authors: Aljifan Mohammad K. , Alshehri Ahmad M. , Alharbi Reham M. , Al Alhareth Mohammed S. , Alharbi Zakiyah A. , Alamri Samirah M. , Alshahrani Nawaf S. , Alyamani Almuayyad E. , Alzahrani Abdulrahman A. , Alqarni Abdulkarim A. , Al Joaithen Meznah S. 
Published: December 2022

Given the inherent qualities of this medium, particularly when contrasted to enamel bonding, bonding to dentin is considered to be a less dependable approach. Further, when dentin is reduced, a sizable amount of cutting detritus coats the dentin's exterior, forming the smear layer. A steep decrease in interfacial adhesion over time has been attributed to the collagen web's inadequate resin impregnation as a result of the dentinal surface preparation with strong acidic agents like phosphoric acid, which left a zone of vulnerable collagen at the root of the hybrid smear layer. Self-etching priming agents that comprise acidic, non-cleansing, polymerizing monomers cause demineralization of the surface and encapsulate the collagen fibers and hydroxyapatite crystals while dissolving the smear layer or incorporating it into the adhesion interface. The concurrent occurrence of dentinal demineralization and monomeric penetration prevents collagen from buckling and shields an exposed collagen web. There may be a drawback to including the smear layer in the hybrid layer, according to certain investigations. Adhesion issues could arise even though the smear layer is reinforced with impregnated resin. To achieve dependable, robust resin-dentin connections, such defects may need to be removed by integrating a distinct etching process because they can reduce the resistance and longevity of the conjugated smear layer. In relation to a traditional bonding system, is has been discovered that removing the smear layer with 0.5 M ethylene diamine tetra-acetic acid (EDTA) before applying a self-etching primer result in greater bond strengths. Even though this approach integrates the smear layer within the adhesion interface, the pre-conditioning of dentin with just an acidic primer is highly convincing and merits additional exploration for the streamlined total-etching systems.