bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nolli Map: Interpretation of Urban Morphology Based on Machine Learning
Authors: Dong Zhiyong , Lin Jinru 
Published: April 2023

Abstract
Nolli map is the earliest diagram tool to simplify and quantify urban form, which most intuitively reflects the spatial layout of tangible elements in the city. The urban morphology contains its inherent evolutionary laws. Exploring the inner rules of cities is helpful for people to conduct urban research and design. Unlike the traditional research methods of urban morphology, the neural network algorithm provides us with new ideas for understanding urban morphology. In this experiment, we label 136 European cities samples in the rules of Nolli map as a training set for machine learning. We use Generative Adversarial Networks (GAN) for multiple mapping experiments. The generated images present recognizable and plausible images of the urban fabric. The results show that the machine can learn the inherent laws of complex urban fabrics, which expands a new applied method for the study of urban morphology.
Hexagonal Responsive Facade Prototype in Responding Sunlight
Authors: Ningsih Tria Amalia , Chintianto Abraham , Pratomo Cahyo , Milleza Muhammad Haikal , Rahman Muhammad Arif , Chairunnisa Intan 
Published: April 2023

Abstract
This paper discusses an architectural responsive façade system using hexagonal parametric forms and kinetic mechanism which responds sunlight. Its purposes are to buffer excessive sun exposure that goes through interior space and maximize the covering area with an incremental rotational joint system. The study aims to explore responsive façade system as second skin for architectural building, focusing on design, mechanism, and fabrication processes. The prototype consists of three parts: the hexagonal modules where the membranes and its frames are compacted; a series of levers to synchronize the movement of opening the membranes from each module; and a structural framework to hold each module as united kinetic façade system. As a preliminary prototype, the system can potentially be applied to several types of existing buildings and easily installed in various sizes and configuration. This kinetic mechanism can decrease sun radiation up to 50% than unprotected window façade.
Probing right-handed neutrinos dipole operators
Authors: Barducci Daniele , Bertuzzo Enrico , Taoso Marco , Toni Claudio 
Published: April 2023

Abstract
We consider the minimal see-saw extension of the Standard Model with two right-handed singlet fermions N1,2 with mass at the GeV scale, augmented by an effective dipole operator between the sterile states. We firstly review current bounds on this effective interaction from fixed-target and collider experiments, as well as from astrophysical and cosmological observations. We then highlight the prospects for testing the decay N2 → N1γ induced by the dipole at future facilities targeting long-lived particles such as ANUBIS, CODEX-b, FACET, FASER 2, MAPP and SHiP.
Quantifying limits on CP violating phases from EDMs in supersymmetry
Authors: Kaneta Kunio , Nagata Natsumi , Olive Keith A. , Pospelov Maxim , Velasco-Sevilla Liliana 
Published: April 2023

Abstract
We revisit the calculation of the electron, neutron, and proton electric dipole moments (EDMs) in the constrained minimal supersymmetric standard model (CMSSM). The relatively large mass of the Higgs boson, mH ≃ 125 GeV coupled with the (as yet) lack of discovery of any supersymmetric particle at the LHC, has pushed the supersymmetry breaking scale to several TeV or higher. Though one might expect this decoupling to have relaxed completely any bounds on the two CP violating phases in the CMSSM (θμ and θA), the impressive experimental improvements in the limits on the EDMs (particularly the electron EDM) still allow us to set constraints of order (0.01−0.1)π on θA and (0.001−0.1)π on θμ. We also discuss the impact of future improvements in the experimental limits on supersymmetric models.
Falling Drop in an Unbounded Liquid Reservoir: Steady-state Solutions
Authors: Eiter Thomas , Kyed Mads , Shibata Yoshihiro 
Published: April 2023

AbstractThe equations governing the motion of a three-dimensional liquid drop moving freely in an unbounded liquid reservoir under the influence of a gravitational force are investigated. Provided the (constant) densities in the two liquids are sufficiently close, existence of a steady-state solution is shown. The proof is based on a suitable linearization of the equations. A setting of function spaces is introduced in which the corresponding linear operator acts as a homeomorphism.
Haplotype-tagged SNPs improve genomic prediction accuracy for Fusarium head blight resistance and yield-related traits in wheat
Authors: Alemu Admas , Batista Lorena , Singh Pawan K. , Ceplitis Alf , Chawade Aakash 
Published: April 2023

AbstractKey messageLinkage disequilibrium (LD)-based haplotyping with subsequent SNP tagging improved the genomic prediction accuracy up to 0.07 and 0.092 for Fusarium head blight resistance and spike width, respectively, across six different models.AbstractGenomic prediction is a powerful tool to enhance genetic gain in plant breeding. However, the method is accompanied by various complications leading to low prediction accuracy. One of the major challenges arises from the complex dimensionality of marker data. To overcome this issue, we applied two pre-selection methods for SNP markers viz. LD-based haplotype-tagging and GWAS-based trait-linked marker identification. Six different models were tested with preselected SNPs to predict the genomic estimated breeding values (GEBVs) of four traits measured in 419 winter wheat genotypes. Ten different sets of haplotype-tagged SNPs were selected by adjusting the level of LD thresholds. In addition, various sets of trait-linked SNPs were identified with different scenarios from the training-test combined and only from the training populations. The BRR and RR-BLUP models developed from haplotype-tagged SNPs had a higher prediction accuracy for FHB and SPW by 0.07 and 0.092, respectively, compared to the corresponding models developed without marker pre-selection. The highest prediction accuracy for SPW and FHB was achieved with tagged SNPs pruned at weak LD thresholds (r2 < 0.5), while stringent LD was required for spike length (SPL) and flag leaf area (FLA). Trait-linked SNPs identified only from training populations failed to improve the prediction accuracy of the four studied traits. Pre-selection of SNPs via LD-based haplotype-tagging could play a vital role in optimizing genomic selection and reducing genotyping costs. Furthermore, the method could pave the way for developing low-cost genotyping methods through customized genotyping platforms targeting key SNP markers tagged to essential haplotype blocks.
A phenomenological perspective on AI ethical failures: The case of facial recognition technology
Authors: Wen Yuni , Holweg Matthias 
Published: April 2023

AbstractAs more and more companies adopt artificial intelligence to increase the efficiency and effectiveness of their products and services, they expose themselves to ethical crises and potentially damaging public controversy associated with its use. Despite the prevalence of AI ethical problems, most companies are strategically unprepared to respond effectively to the public. This paper aims to advance our empirical understanding of company responses to AI ethical crises by focusing on the rise and fall of facial recognition technology. Specifically, through a comparative case study of how four big technology companies responded to public outcry over their facial recognition programs, we not only demonstrated the unfolding and consequences of public controversies over this new technology, but also identified and described four major types of company responses—Deflection, Improvement, Validation, and Pre-emption. These findings pave the way for future research on the management of controversial technology and the ethics of AI.
Impact of the genetic improvement of fermenting yeasts on the organoleptic properties of beer
Authors: Astola Antonio , Durán-Guerrero Enrique , Díaz Ana Belén , Lasanta Cristina , Castro Remedios 
Published: April 2023

AbstractThe brewing industry has experienced a significant boom in recent years through the emergence of, on the one hand, craft breweries that produce beers with unique organoleptic characteristics, and, on the other hand, the brewing of a significant number of beers using hybridized or genetically modified microorganisms with the aim of improving both the brewing processes and the final products. This review covers the influence from yeast strains on the organoleptic properties of the final beers and also the main hybridization and genetic modification methods applied to such yeast strains with the aim of improving the sensory characteristics of the product obtained and/or the brewing process. Different approaches to the phenotypic modification of the yeasts used in beer brewing have arisen in recent years. These are dealt with in this work, with special emphasis on the methodology followed as well as on the effects of the same on the brewing process and/or on the final product.
Chaotic Behavior in Diffusively Coupled Systems
Authors: Nijholt Eddie , Pereira Tiago , Queiroz Fernando C. , Turaev Dmitry 
Published: April 2023

AbstractWe study emergent oscillatory behavior in networks of diffusively coupled nonlinear ordinary differential equations. Starting from a situation where each isolated node possesses a globally attracting equilibrium point, we give, for an arbitrary network configuration, general conditions for the existence of the diffusive coupling of a homogeneous strength which makes the network dynamics chaotic. The method is based on the theory of local bifurcations we develop for diffusively coupled networks. We, in particular, introduce the class of the so-called versatile network configurations and prove that the Taylor coefficients of the reduction to the center manifold for any versatile network can take any given value.
Predictors and Prognostic Significance of Postoperative Complications for Patients with Intrahepatic Cholangiocarcinoma
Authors: Endo Yutaka , Moazzam Zorays , Woldesenbet Selamawit , Araujo Lima Henrique , Alaimo Laura , Munir Muhammad Musaab , Shaikh Chanza F. , Guglielmi Alfredo , Aldrighetti Luca , Weiss Matthew , Bauer Todd W. , Alexandrescu Sorin , Poultsides George A. , Kitago Minoru , Maithel Shishir K. , Marques Hugo P. , Martel Guillaume , Pulitano Carlo , Shen Feng , Cauchy François , Koerkamp Bas Groot , Endo Itaru , Pawlik Timothy M. 
Published: April 2023

AbstractBackgroundThe prognostic impact of major postoperative complications (POCs) for intrahepatic cholangiocarcinoma (ICC) remains ill‐defined. We sought to analyze the relationship between POCs and outcomes relative to lymph node metastases (LNM) and tumor burden score (TBS).
MethodsPatients who underwent resection of ICC between 1990–2020 were included from an international database. POCs were defined according to Clavien‐Dindo classification ≥ 3. The prognostic impact of POCs was estimated relative to TBS categories (i.e., high and low) and lymph node status (i.e., N0 or N1).ResultsAmong 553 patients who underwent curative‐intent resection for ICC, 128 (23.1%) individuals experienced POCs. Low TBS/N0 patients who experienced POCs presented with a higher risk of recurrence and death (3‐year cumulative recurrence rate; POCs: 74.8% vs. no POCs: 43.5%, p = 0.006; 5‐year overall survival [OS], POCs 37.8% vs. no POCs 65.8%, p = 0.003), while POCs were not associated with worse outcomes among high TBS and/or N1 patients. The Cox regression analysis confirmed that POCs were significant predictors of poor outcomes in low TBS/N0 patients (OS, hazard ratio [HR] 2.91, 95%CI 1.45–5.82, p = 0.003; recurrence free survival [RFS], HR 2.42, 95%CI 1.28–4.56, p = 0.007). Among low TBS/N0 patients, POCs were associated with early recurrence (within 2 years) (Odds ratio [OR] 2.79 95%CI 1.13–6.93, p = 0.03) and extrahepatic recurrence (OR 3.13, 95%CI 1.14–8.54, p = 0.03), in contrast to patients with high TBS and/or nodal disease.ConclusionsPOCs were independent, negative prognostic determinants for both OS and RFS among low TBS/N0 patients. Perioperative strategies that minimize the risk of POCs are critical to improving prognosis, especially among patients harboring favorable clinicopathologic features.
Risk–benefit ratio of percutaneous kyphoplasty and percutaneous vertebroplasty in patients with newly diagnosed multiple myeloma with vertebral fracture: a single-center retrospective study
Authors: Xiang Qiu-Qing , Chu Bin , Lu Min-Qiu , Shi Lei , Gao Shan , Wang Yu-Tong , Fang Li-Juan , Ding Yue-Hua , Zhao Xin , Chen Yuan , Wang Meng-Zhen , Hu Wei-Kai , Wang Li-Fang , Sun Kai , Bao Li 
Published: April 2023

AbstractThe indications for percutaneous kyphoplasty (PKP) and percutaneous vertebroplasty (PVP) are painful vertebral compression fractures. Our study is to assess the risk–benefit ratio of PKP/PVP surgery in the patients with newly diagnosed multiple myeloma (NDMM) without receiving antimyeloma therapy. The clinical data of 426 consecutive patients with NDMM admitted to our center from February 2012 to April 2022 were retrospectively analyzed. The baseline data, postoperative pain relief, the proportion of recurrent vertebral fractures, and survival time were compared between the PKP/PVP surgical group and the nonsurgical group in the NDMM patients. Of the 426 patients with NDMM, 206 patients had vertebral fractures (206/426, 48.4%). Of these, 32 (32/206, 15.5%) underwent PKP/PVP surgery for misdiagnosis of simple osteoporosis prior to diagnosis of MM (surgical group), and the other 174 (174/206, 84.5%) did not undergo surgical treatment prior to definitive diagnosis of MM (non-surgical group). The median age of patients in the surgical and nonsurgical groups was 66 and 62 years, respectively (p = 0.01). The proportion of patients with advanced ISS and RISS stages was higher in the surgical group (ISS stage II + III 96.9% vs. 71.8%, p = 0.03; RISS stage III 96.9% vs. 71%, p = 0.01). Postoperatively, 10 patients (31.3%) never experienced pain relief and 20 patients (62.5%) experienced short-term pain relief with a median duration of relief of 2.6 months (0.2–24.1 months). Postoperative fractures of vertebrae other than the surgical site occurred in 24 patients (75%) in the surgical group, with a median time of 4.4 months postoperatively (0.4–86.8 months). Vertebral fractures other than the fracture site at the first visit occurred in 5 patients (2.9%) in the nonoperative group at the time of diagnosis of MM, with a median time of 11.9 months after the first visit (3.5–12.6 months). The incidence of secondary fractures was significantly higher in the surgical group than in the nonsurgical group (75% vs. 2.9%, p = 0.001). The time interval between the first visit and definitive diagnosis of MM was longer in the surgical group than in the nonsurgical group (6.1 months vs. 1.6 months, p = 0.01). At a median follow-up of 32 months (0.3–123 months), median overall survival (OS) was significantly shorter in the surgical group than in the nonsurgical group (48.2 months vs. 66 months, p = 0.04). Application of PKP/PVP surgery for pain relief in NDMM patients without antimyeloma therapy has a limited effect and a high risk of new vertebral fractures after surgery. Therefore, patients with NDMM may need to have their disease controlled with antimyeloma therapy prior to any consideration for PKP/PVP surgery.
Drilling accuracy evaluation of a mouldable surgical targeting system for minimally invasive access to anatomic targets in the temporal bone
Authors: Geiger Lena , Zuniga M. Geraldine , Lenarz Thomas , Majdani Omid , Rau Thomas S. 
Published: April 2023

Abstract
Purpose
Minimally invasive cochlear implant surgery using a micro-stereotactic surgical targeting system with on-site moulding of the template aims for a reliable, less experience-dependent access to the inner ear under maximal reduction of trauma to anatomic structures. We present an accuracy evaluation of our system in ex-vivo testing.

Methods
Eleven drilling experiments were performed on four cadaveric temporal bone specimens. The process involved preoperative imaging after affixing the reference frame to the skull, planning of a safe trajectory preserving relevant anatomical structures, customization of the surgical template, execution of the guided drilling and postoperative imaging for determination of the drilling accuracy. Deviation between the drilled and desired trajectories was measured at different depths.

Results
All drilling experiments were successfully performed. Other than purposely sacrificing the chorda tympani in one experiment, no other relevant anatomy, such as facial nerve, chorda tympani, ossicles or external auditory canal were harmed. Deviation between the desired and achieved path was found to be 0.25 ± 0.16 mm at skulls’ surface and 0.51 ± 0.35 mm at the target level. The closest distance of the drilled trajectories’ outer circumference to the facial nerve was 0.44 mm.

Conclusions
We demonstrated the usability for drilling to the middle ear on human cadaveric specimen in a pre-clinical setting. Accuracy proved to be suitable for many applications such as procedures within the field of image-guided neurosurgery. Promising approaches to reach sufficient submillimetre accuracy for CI surgery have been outlined.
Are lip prints hereditary? A systematic review
Authors: Chaves Tânia , Azevedo Álvaro , Caldas Inês Morais 
Published: April 2023

Abstract
Hereditary lip prints have been studied by several researchers. However, the literature shows no consensus among the scientific community regarding this topic. Therefore, the aim of this study was to conduct a systematic review to gather evidence to clarify whether the surface structure of lip prints is hereditary and, consequently, if a familial relationship between individuals can be established through the analysis of lip prints. The systematic review was performed following the PRISMA (Preferred Reporting Items for Systematic reviews and Meta-Analyses) guidelines. A bibliographic survey was conducted in PubMed, Scopus, and Web of Science databases, restricted to articles published between 2010 and 2020. Studies were selected according to eligibility criteria, and then the study data were collected. The risk of bias of each study was assessed and applied as additional inclusion or exclusion criteria. The results of the articles eligible for analysis were synthesized by a descriptive approach. In the seven included studies, methodological variations, including the definition of similarity, that contribute to the heterogeneity of results were identified. The data gathered allowed to conclude that there is no strong scientific evidence to support the hypothesis of the existence of heredity in the surface structure of lip prints, since it was not proven that similarities between parents and children occur systematically in all families.
Central versus peripheral mechanisms of cold-induced vasodilation: a study in the fingers and toes of people with paraplegia
Authors: Tsoutsoubi Lydia , Ioannou Leonidas G. , Alba Billie K. , Cheung Stephen S. , Daanen Hein A. , Mekjavic Igor B. , Flouris Andreas D. 
Published: April 2023

Abstract
Purpose
This study examined physiological and perceptual parameters related to cold-induced vasodilation (CIVD) in the fingers and toes of people with paraplegia and compared them with responses observed in able-bodied individuals.

Methods
Seven participants with paraplegia and seven able-bodied individuals participated in a randomized matched-controlled study involving left-hand and -foot immersion in cold water (8 ± 1 °C) for 40 min during exposure to cool (16 ± 1 °C), thermoneutral (23 ± 1 °C), and hot (34 ± 1 °C) ambient conditions.

Results
Similar CIVD occurrence was observed in the fingers in the two groups. In toes, three of the seven participants with paraplegia revealed CIVDs: one in cool, two in thermoneutral, and three in hot conditions. No able-bodied participants revealed CIVDs in cool and thermoneutral conditions, while four revealed CIVDs in hot conditions. The toe CIVDs of paraplegic participants were counterintuitive in several respects: they were more frequent in cool and thermoneutral conditions (compared to the able-bodied participants), emerged in these conditions despite lower core and skin temperatures of these participants, and were evident only in cases of thoracic level lesions (instead of lesions at lower spinal levels).

Conclusion
Our findings demonstrated considerable inter-individual variability in CIVD responses in both the paraplegic and able-bodied groups. While we observed vasodilatory responses in the toes of participants with paraplegia that technically fulfilled the criteria for CIVD, it is unlikely that they reflect the CIVD phenomenon observed in able-bodied individuals. Taken together, our findings favor the contribution of central over peripheral factors in relation to the origin and/or control of CIVD.
Regional and time course differences in sweat cortisol, glucose, and select cytokine concentrations during exercise
Authors: King Michelle A. , Brown Shyretha D. , Barnes Kelly A. , De Chavez Peter John D. , Baker Lindsay B. 
Published: April 2023

Abstract
Introduction
The use of sweat as a biofluid for non-invasive sampling and diagnostics is a popular area of research. However, concentrations of cortisol, glucose, and cytokines have not been described across anatomical regions or as time progresses throughout exercise.

Purpose
To determine regional and time course differences in sweat cortisol, glucose, and select cytokines (EGF, IFN-γ, IL-1β, IL-1α, IL-1ra, TNF-α, IL-6, IL-8, and IL-10).

Methods
Sweat was collected with absorbent patches from eight subjects (24–44 y; 80.2 ± 10.2 kg) on the forehead (FH), right dorsal forearm (RDF), right scapula (RS), and right triceps (RT) at 0–25 min, 30–55 min, and 60–85 min during 90 min of cycling (~ 82% HRmax) in a heated chamber (32 °C, 50% rh). ANOVA was used to determine the effect of site and time on outcomes. Data are reported as LS means ± SE.

Results
There was a significant effect of location on sweat analyte concentrations with FH having higher values than most other regions for cortisol (FH: 1.15 ± 0.08 ng/mL > RDF: 0.62 ± 0.09 ng/mL and RT: 0.65 ± 0.12 ng/mL, P = 0.02), IL-1ra (P < 0.0001), and IL-8 (P < 0.0001), but lower concentrations for glucose (P = 0.01), IL-1α (P < 0.0001), and IL-10 (P = 0.02). Sweat IL-1β concentration was higher on the RS than RT (P < 0.0001). Sweat cortisol concentration increased (25 min: 0.34 ± 0.10 ng/mL < 55 min: 0.89 ± 0.07 ng/mL < 85 min: 1.27 ± 0.07 ng/mL; P < 0.0001), while EGF (P < 0.0001), IL-1ra (P < 0.0001), and IL-6 (P = 0.02) concentrations decreased over time.

Conclusion
Sweat analyte concentrations varied with time of sampling and anatomical region, which is essential information to consider when conducting future work in this area.

Clinical trial identifier
NCT04240951 registered January 27, 2020.