bluuebunny/crossref_metadata_2025_split huggingface dataset:
How Personal Relationships Affect Employment Outcomes: On the Role of Social Networks and Family Obligations
Authors: Lalive Rafael , Oesch Daniel , Pellizzari Michele 
Published: January 2023

AbstractThis chapter shows that individuals’ trajectories in personal networks and the labour market are closely intertwined. A person’s network facilitates access to jobs in different ways. As people create relationships and accumulate social contacts, they obtain more information about job opportunities and embark on more rewarding careers. However, personal relationships may also hamper employment prospects. If employers expect that the obligations accruing from family-care reduce productivity, the consequence will be stunted careers and lower wages, notably for mothers. Yet the extent to which social relations help or hinder work trajectories varies across Europe and crucially depends on employment and family policies. Moreover, the spill-over effects between the two life domains travel both ways as employment outcomes also affect personal relationships. A prime example is how job loss affects the stability of partnerships. While recessions reduce the divorce rate at the aggregate level, the minority of individuals who lose their jobs are more likely to see their couples break up. Our chapter discusses the theory of spill-over effects between social relations and employment and reviews cutting-edge research in economics and sociology on the topic.
Synthesis: A Multidimensional Perspective on Vulnerability and the Life Course
Authors: Bernardi Laura , Bolano Danilo 
Published: January 2023

AbstractThis first section shows that the concept of the interdependency of life domains is of utmost importance. Typically, such interdependency is detected when decisions, events and transitions in one life domain influence those in another, producing spillover effects. Spillovers across life domains take the form of resources generated or drained by one life domain that facilitate or hinder actions and well-being in another life domain. In this synthesis, we discuss how positive and negative spillovers across life domains can lead to a better understanding of life course vulnerability. We also relate the spillovers across life domains of related individuals and the way in which spillovers are regulated by the structural embeddedness into specific contexts. We illustrate our purpose through examples taken from research carried out by LIVES research program. We conclude by arguing that life domains interdependencies call for life course policies that explicitly consider spillover effects. Current policies addressing a specific life domain at the time have often unintended consequences that shall not be neglected. For instance, policies increasing pension age, do not only shape the employment trajectories, but have also have consequences on time available for leisure and care as well as on opportunities to relocate after retirement.
Application of 89Zr-DFO*-immuno-PET to assess improved target engagement of a bispecific anti-amyloid-ß monoclonal antibody
Authors: Stergiou N. , Wuensche T. E. , Schreurs M. , Mes I. , Verlaan M. , Kooijman E. J. M. , Windhorst A. D. , Helboe L. , Vergo S. , Christensen S. , Asuni A. A. , Jensen A. , Van Dongen G. A. M. S. , Bang-Andersen B. , Vugts D. J. , Beaino W. 
Published: January 2023

Abstract
Purpose
The recent conditional FDA approval of Aducanumab (Adu) for treating Alzheimer’s disease (AD) and the continued discussions around that decision have increased interest in immunotherapy for AD and other brain diseases. Reliable techniques for brain imaging of antibodies may guide decision-making in the future but needs further development. In this study, we used 89Zr-immuno-PET to evaluate the targeting and distribution of a bispecific brain-shuttle IgG based on Adu with transferrin receptor protein-1 (TfR1) shuttling mechanism, mAbAdu-scFab8D3, designated Adu-8D3, as a candidate theranostic for AD. We also validated the 89Zr-immuno-PET platform as an enabling technology for developing new antibody-based theranostics for brain disorders.

Methods
Adu, Adu-8D3, and the non-binding control construct B12-8D3 were modified with DFO*-NCS and radiolabeled with 89Zr. APP/PS1 mice were injected with 89Zr-labeled mAbs and imaged on days 3 and 7 by positron emission tomography (PET). Ex vivo biodistribution was performed on day 7, and ex vivo autoradiography and immunofluorescence staining were done on brain tissue to validate the PET imaging results and target engagement with amyloid-β plaques. Additionally, [89Zr]Zr-DFO*-Adu-8D3 was evaluated in 3, 7, and 10-month-old APP/PS1 mice to test its potential in early stage disease.

Results
A 7-fold higher brain uptake was observed for [89Zr]Zr-DFO*-Adu-8D3 compared to [89Zr]Zr-DFO*-Adu and a 2.7-fold higher uptake compared to [89Zr]Zr-DFO*-B12-8D3 on day 7. Autoradiography and immunofluorescence of [89Zr]Zr-DFO*-Adu-8D3 showed co-localization with amyloid plaques, which was not the case with the Adu and B12-8D3 conjugates. [89Zr]Zr-DFO*-Adu-8D3 was able to detect low plaque load in 3-month-old APP/PS1 mice.

Conclusion
89Zr-DFO*-immuno-PET revealed high and specific uptake of the bispecific Adu-8D3 in the brain and can be used for the early detection of Aβ plaque pathology. Here, we demonstrate that 89Zr-DFO*-immuno-PET can be used to visualize and quantify brain uptake of mAbs and contribute to the evaluation of biological therapeutics for brain diseases.
Do major health shocks affect the interconnectedness of E-commerce and electronic payment markets? a regional analysis
Authors: Gunay Samet , Prentice Catherine , Sraieb Mohamed 
Published: January 2023

AbstractIn view of the recent pandemic and its associated impact, this study examines the relationship between e-commerce and mobile/electronic payment markets by utilizing two indices as proxies of these market developments. The study employed DCC-GARCH modeling, Hacker–Hatemi bootstrap causality test, Diebold–Yilmaz volatility spillover analysis and a volatility modeling incorporating COVID19 related death statistics of three regions: America, Europe and Asia. The results show that while the two markets display very high time-varying correlations across years, a significant causal relationship is only found during the pandemic. Causality runs from the mobile/electronic payment index to the e-commerce index. Volatility spillover analysis further supports this finding. Interestingly, the mobile/electronic payment index tends to become a net volatility transmitter in the pandemic period. When we incorporate regional COVID19 statistics on cases and deaths in the volatility modeling of the e-commerce index, we find that only COVID19 deaths in Europe have a significant effect on e-commerce returns. This result may be rationalized by the relative tightness of the e-commerce market in Europe compared to America and Asia. Likewise, demographic characteristics might be another potential driver for our findings.
LGBT + academics’ and PhD students’ experiences of visibility in STEM: more than raising the rainbow flag
Authors: Reggiani Marco , Gagnon Jessica Dawn , Lunn Rebecca Jane 
Published: January 2023

Abstract
The experiences of lesbian, gay, bisexual, and transgender (LGBT +) individuals in Science, Technology, Engineering, and Mathematics (STEM) are still understudied and, despite some improvements, are still characterised by patterns of exclusion, disadvantage, and discrimination. In this article, we explore how visibility is perceived and navigated by LGBT + academics and PhD students in STEM, with a focus on the ways that interlocking systems of oppression impact people and groups who are marginalised and historically excluded. This article draws on a broader research project about the experiences of women and LGBT + people in STEM that was conducted between 2019 and 2020 at a UK university and is framed by intersectionality theory. Based on the thematic analysis of interviews and focus groups with 24 LGBT + participants, findings suggest that visibility is still a risk for LGBT + academics and PhD students in STEM. We found that the labour of navigating visibility was perceived as an unfair disadvantage and that the focus on individuals’ visibility in the absence of meaningful and transformative inclusion initiatives by higher education institutions was regarded as tokenistic. The article argues that addressing LGBT + visibility should firstly be an institutional responsibility and not an individual burden and that this work is essential to set the conditions for personal visibility to happen by choice, safely and without retribution.
Effects of urbanization-induced local alterations on the diversity and assemblage structure of macroinvertebrates in low-order streams
Authors: Bohus Attila , Gál Blanka , Barta Barbara , Szivák Ildikó , Karádi-Kovács Kata , Boda Pál , Padisák Judit , Schmera Dénes 
Published: January 2023

AbstractUrbanization is one of the most serious threats to stream ecosystems worldwide. It is crucial to understand its effects on stream organisms as a prerequisite for the mitigation of urban degradation. Our aim was to investigate the general effects of urbanization in a moderately urbanized landscape and to assess the relationship between local environmental variables and biotic attributes of macroinvertebrate assemblages. Multiple sites at low-order streams flowing from natural forested areas to moderately urbanized landscapes were surveyed. We found that local habitat properties presented degraded conditions at urban sites. Urbanization had a negative effect on the richness and Shannon diversity of macroinvertebrate assemblages, and altered assemblage composition. Biotic assemblage parameters showed negative, neutral or positive relationships with local physical parameters. Concrete cover was one of the most important variables, which explained a decreasing richness and diversity of macroinvertebrates. In natural conditions, microhabitat-level environmental variables significantly impacted community variation, while in degraded conditions microhabitat and site-level environmental variables had a substantial impact together. Individual streams showed considerable variability under natural conditions, as well as in their response to urban effects. Subsequently, the mitigation of the effects of urbanization might also need considerable variability in the type of actions required.
Substance addiction: cure or care?
Authors: Chinchella Nicola , Hipólito Inês 
Published: January 2023

AbstractSubstance addiction has been historically conceived and widely researched as a brain disease. There have been ample criticisms of brain-centred approaches to addiction, and this paper aims to align with one such criticism by applying insights from phenomenology of psychiatry. More precisely, this work will apply Merleau-Ponty’s insightful distinction between the biological and lived body. In this light, the disease model emerges as an incomplete account of substance addiction because it captures only its biological aspects. When considering addiction as a brain disorder, it will be shown that research fails to account for the contextual, functional, and emotional aspects inherent to subjective health. It is concluded that, while the disease model is fundamental to our understanding of what happens in the brain, its brain-centred approach is cure-oriented. Instead, we suggest a care-orientated approach, which understands and treats the psychological feel as bodily experience situated in an environment, allowing for a more encompassing therapeutic perspective.
Quality of life implications for elevated trait impulsivity in people with Parkinson’s disease
Authors: Jeyadevan Ashani , Bakeberg Megan , Byrnes Michelle , Kenna Jade , McGregor Sarah , Ghosh Soumya , Horne Malcom K. , Stell Rick , Evans Tess , Mastaglia Frank L. , Anderton Ryan 
Published: January 2023

Abstract
Background
Several non-motor features of Parkinson’s disease (PD) are known to adversely affect patient health-related quality of life (HRQL). However, the specific impact of neuropsychiatric complications, such as impulsive behaviour, is yet to be elucidated.

Objectives
The present cross-sectional, observational study aimed to investigate the effects of heightened trait impulsivity on HRQL in individuals with PD.

Methods
A total of 322 people with idiopathic PD were sequentially recruited from Movement Disorder clinics across Australia. Trait impulsivity in patients was determined by Barratt’s Impulsiveness Scale Version 11 (BIS-11), and grouped into tertiles (low, medium, and high). Patient HRQL was determined by the 39-item Parkinson’s Disease Questionnaire (PDQ-39), complemented by the Cambridge Behavioural Inventory-Revised (CBI-R) indicating caregivers’ perception of patient HRQL.

Results
When total BIS-11 scores were grouped into tertiles, patient perceived and caregiver-perceived HRQL were 1.7-fold (p < .001) and 2.2-fold (p < .001) worse in the high BIS-11 group when compared to patients in the low group. Univariate analysis revealed significant associations between second-order attentional (p < .001) and non-planning (p < .001) impulsivity domains with PDQ-39 scores. When controlling for confounding demographic and clinical variables, a multivariate linear regression model revealed second-order attentional impulsivity was independently predictive of poor patient perceived HRQL (p < .001).

Conclusion
These findings suggest that increasing trait impulsivity is significantly associated with patient perceived HRQL in PD. Improved knowledge and recognition of subclinical impulsivity may guide clinicians’ treatment and reduce disease burden for patients experiencing PD symptoms.
Hybrid CPU–GPU implementation of the transformed spatial domain channel estimation algorithm for mmWave MIMO systems
Authors: Lloria Diego , Aviles Pablo M. , Belloch Jose A. , Roger Sandra , Botella-Mascarell Carmen , Lindoso Almudena 
Published: January 2023

AbstractHybrid platforms combining multicore central processing units (CPU) with many-core hardware accelerators such as graphic processing units (GPU) can be smartly exploited to provide efficient parallel implementations of wireless communication algorithms for Fifth Generation (5G) and beyond systems. Massive multiple-input multiple-output (MIMO) systems are a key element of the 5G standard, involving several tens or hundreds of antenna elements for communication. Such a high number of antennas has a direct impact on the computational complexity of some MIMO signal processing algorithms. In this work, we focus on the channel estimation stage. In particular, we develop a parallel implementation of a recently proposed MIMO channel estimation algorithm. Its performance in terms of execution time is evaluated both in a multicore CPU and in a GPU. The results show that some computation blocks of the algorithm are more suitable for multicore implementation, whereas other parts are more efficiently implemented in the GPU, indicating that a hybrid CPU–GPU implementation would achieve the best performance in practical applications based on the tested platform.
Reproducibility of CT radiomic features in lung neuroendocrine tumours (NETs) patients: analysis in a heterogeneous population
Authors: Bicci Eleonora , Cozzi Diletta , Cavigli Edoardo , Ruzga Ron , Bertelli Elena , Danti Ginevra , Bettarini Silvia , Tortoli Paolo , Mazzoni Lorenzo Nicola , Busoni Simone , Miele Vittorio 
Published: January 2023

Abstract
Background
The aim is to find a correlation between texture features extracted from neuroendocrine (NET) lung cancer subtypes, both Ki-67 index and the presence of lymph-nodal mediastinal metastases detected while using different computer tomography (CT) scanners.

Methods
Sixty patients with a confirmed pulmonary NET histological diagnosis, a known Ki-67 status and metastases, were included. After subdivision of primary lesions in baseline acquisition and venous phase, 107 radiomic features of first and higher orders were extracted. Spearman’s correlation matrix with Ward’s hierarchical clustering was applied to confirm the absence of bias due to the database heterogeneity. Nonparametric tests were conducted to identify statistically significant features in the distinction between patient groups (Ki-67 < 3—Group 1; 3 ≤ Ki-67 ≤ 20—Group 2; and Ki-67 > 20—Group 3, and presence of metastases).

Results
No bias arising from sample heterogeneity was found. Regarding Ki-67 groups statistical tests, seven statistically significant features (p value < 0.05) were found in post-contrast enhanced CT; three in baseline acquisitions. In metastasis classes distinction, three features (first-order class) were statistically significant in post-contrast acquisitions and 15 features (second-order class) in baseline acquisitions, including the three features distinguishing between Ki-67 groups in baseline images (MCC, ClusterProminence and Strength).

Conclusions
Some radiomic features can be used as a valid and reproducible tool for predicting Ki-67 class and hence the subtype of lung NET in baseline and post-contrast enhanced CT images. In particular, in baseline examination three features can establish both tumour class and aggressiveness.
Pareto efficiency without topology
Authors: Kountzakis Christos , Rossello Damiano 
Published: January 2023

AbstractGiven a vector optimization problem over spaces endowed with a topological linear structure, existence results for optima (efficient points) are known. Relying only on the linear structure, the set of properly efficient points from a convex set is proved to be nonempty and the sets of Proper efficient points and Pareto efficient points coincide, provided that the set of internal points picked from the corresponding cone is nonempty. This result is appealing since the scalarization of the vector optimization problem is valid without topological requirements. A As an important consequence, we provide the Second Welfare Theorem in vector lattices and especially in Lebesgue spaces holds without topology.
Degrowth and agri-food systems: a research agenda for the critical social sciences
Authors: Guerrero Lara Leonie , van Oers Laura , Smessaert Jacob , Spanier Julia , Raj Guilherme , Feola Giuseppe 
Published: January 2023

AbstractDegrowth has become a recognised paradigm for identifying and critiquing systemic unsustainability rooted in the capitalist, growth-compelled economy. Increasingly, degrowth is discussed in relation to specific economic sectors such as the agri-food system. This paper builds on the foundational work of Gerber (2020) and Nelson and Edwards (2021). While both publications take a rather specific analytical or disciplinary focus—the former specifically connects critical agrarian studies and degrowth, the latter explores the contributions of the recent volume ‘Food for degrowth’—this paper takes stock of the emerging body of literature on degrowth and agri-food systems more broadly. It proposes research avenues that deepen, expand and diversify degrowth research on agri-food systems in four areas: (i) degrowth conceptualisations; (ii) theorisation of transformations towards sustainability; (iii) the political economy of degrowth agri-food systems; and (iv) rurality and degrowth. Together, these avenues devote due attention to a variety of agents (ranging from translocal networks to non-humans), spaces (e.g. the rural), theories (e.g. sustainability transitions and transformations towards sustainability) and policies (of the agricultural sector and beyond) that thus far have received limited attention within the degrowth literature. The critical social science perspective on degrowth agri-food systems, which is advanced in this paper, illuminates that the present unsustainability and injustice of hegemonic agri-food systems are not merely a problem of that sector alone, but rather are ingrained in the social imaginaries of how economies and societies should work as well as in the political–economic structures that uphold and reproduce these imaginaries.
A Non-archimedean Variant of Littlewood–Paley Theory for Curves
Authors: Hickman Jonathan , Wright James 
Published: January 2023

AbstractWe prove a variant of a square function estimate for the extension operator associated to the moment curve in non-archimedean local fields. The arguments rely on a structural analysis of congruences (sublevel sets) of univariate polynomials over field extensions of the base field. Our analysis can be adapted to the archimedean setting as well.
Developing Inclusivity from Within: Advancing Our Understanding of How Teachers’ Personality Characters Impact Ethnic Prejudice and Homophobic Attitudes
Authors: D’Urso Giulio , Maynard Andrea , Petruccelli Irene , Di Domenico Alberto , Fasolo Mirco 
Published: January 2023

Abstract
Introduction
Understanding how internal characteristics of teachers impact their teaching practices can shed light onto ways to promote inclusivity. Specifically, teachers’ personality traits and social anxiety could influence their acceptance of others, influencing student acceptance and achievement, yet minimal research has explored these relationships.

Method
The role of personality characteristics and social anxiety related to ethnic prejudices and homophobic attitudes were investigated in a sample of 551 Italian secondary school teachers (76% female, age range: 20–70; M = 46.20) using the teachers’ attitudes towards the representation of homosexuality in film and television scale, the big five questionnaire short form, the subtle and blatant prejudice scales, and the Social Phobia Inventory.

Results
The first model suggested that higher levels of conscientiousness combine with lower levels of agreeableness and extraversion are related to blatant prejudice. As participant age increased, those with lower levels of agreeableness and higher levels of conscientiousness expressed subtle prejudice. Increased age combine with lower levels of agreeableness was also linked to negative attitudes towards lesbian and gay topics. Similar results were found in the second model, which included social anxiety; however, social anxiety was found to impact negative attitudes towards lesbian and gay topics only, while the effect of age towards subtle prejudice disappeared.

Conclusions
Personological characteristics such as personality and social anxiety were found to impact ones attitudes and acceptance towards ethnic groups and lesbian and gay populations.

Policy Implications
Our findings highlight key areas of focus to help raise awareness and address socio-emotional through school supports, teacher trainings, and policy aimed at promoting inclusive education systems.