bluuebunny/crossref_metadata_2025_split huggingface dataset:
Biomechanical and physiological responses to allowable load handling limits in Iranian female workers
Authors: Nourollahi‐Darabad Maryam , Mojaddam Maryam , Dianat Iman , Afshari Davood 
Published: August 2023

AbstractIn 2017, load limit values for manual material handling (MMH) tasks were confirmed to protect workers from low back disorders without prior validity investigation for Iranian workers. The present study investigated the applicability and feasibility of the Washington State Department of Labor and Industries (WISHA) lifting method as an occupational exposure limit (OEL) for the MMH tasks in a sample of young Iranian female workers using biomechanical and physiological criteria. A laboratory study was conducted with 10 female participants performing lifting tasks as described in the Iranian OEL for the MMH tasks based on the WISHA checklist. Each participant completed 21 lifting task combinations that varied in height and reach with the maximal allowable load. To test the applicability of the WISHA method, the maximum aerobic capacity and the equivalent heart rate (EHR) were estimated for 10 young Iranian female workers using an ergometer and Astrand protocol. Moreover, spinal loads for each lifting task were calculated using a static biomechanical model. From a physiological point of view, approximately 38% of the lifting tasks resulted in an increase in the physical workload. For 33% of the lifting trials, the estimated compression loads exceeded 3400 N. The findings revealed that the weight and lift height of the loads affected the lifting capacity of the participants. It seems that the allowable weight limits for manual lifting are not matched to the biomechanical and physiological capacities of the Iranian women. Therefore, the Iranian guideline for manual lifting is recommended to be revised based on the physiological and biomechanical capacities of the Iranian women.
Service design activities in health services: A systematic literature review based on ecosystem perspective and transformative approach
Authors: Vaz Noé , Araujo Cláudia Affonso Silva 
Published: August 2023

AbstractService Design (SD) represents a breakthrough in searching for solutions to health systems challenges, but the activities that support these solutions remain underexplored. This research investigates how SD has been applied in the healthcare sector based on two conceptual models: multilevel ecosystem perspective and SD transformative approach. First, we conducted a systematic literature review in eight comprehensive databases in March 2021. Eligibility criteria returned 990 articles filtered by a search protocol, resulting in 47 studies. After this, we identified 23 studies (49%) with a transformative approach through a thematic analysis. Also, the analysis of these 23 studies allowed the identification of five key aspects necessary for enabling a transformative character of SD initiatives: (1) identification of all the actors that make up the provision of healthcare services, (2) identification of users by ecosystem level, (3) knowledge about the SD tools arsenal, (4) use of technology, and (5) applying the Experience‐Based Design and Co‐Design (EBD/EBCD) approach. The study underlines the role of management for the success of SD in the health sector and suggests an instrument (checklist) to help managers implement SD initiatives successfully.
Retracted: Prevalence of active trachoma infection and associated factors post‐war resettled population in raya kobo districts, North East Ethiopia: A community‐based cross‐sectional study in 2022
Authors: Kebede Fassikaw , Jamal Muhammad 
Published: August 2023

AbstractBackgroundActive trachoma infection poses a serious threat to public health, particularly for those who live in an unprivileged area and has practiced open‐field defecation. This study aimed to estimate the prevalence of active trachoma infection and associated factors in the post‐war resettled population in Raya Kobo district, North East Ethiopia: a community‐based cross‐sectional study in 2022.MethodsA community‐based cross‐sectional study was conducted among 602 participants randomly selected in 14 slum villages in Raya Kobo from February 16th to March 30th, 2023. After the data was collected using a semi‐structured questionnaire and entered into Epi‐data version 3.2. The study participants were chosen using a two‐stage sampling process. Binary logistic regression was used to identify factors for active trachoma infection. Adjusted odds ratios (AORs) with 95% confidence intervals (CIs) were claimed for the strength of association at p < 0.05.ResultsOverall, 602 (99.9%) study participants were included in the final analysis. At the end of the study period, 126 (20.9) participants developed active trachoma infection. On multivariable analysis, were aged ≥45 years (AOR = 7.9, 95% CI = 2.4–25.3), history of eye infection (AOR = 3.7, 95% CI = 2.4–10.4, p = 0.001), were poor wealth index (AOR = 9.2, 95% CI = 2.7–23.7), having separated kitchen (AOR = 4.05, 95% CI = 1.86–8.86), living with animals (AOR = 5.92, 95% CI = 2.31–14.7) and having got administration of mass‐drug (AOR = 8.9, 95% CI = 2.36–33.6) were significant risk factors for active trachoma infection. Whereas, face washing practice regularly (AOR = 0.23, 95% CI = 0.127–0.43), and toilet availability (AOR = 0.35, 95% CI = 0.20–0.97) were preventive factors for active trachoma infection.ConclusionA significant prevalence of active trachoma infection was reported in the area as compared with previous findings and urgent clinical intervention, and the WHO critical SAFE strategies (surgery, antibiotics, facial cleanliness, and environmental improvement) implementation is highly needed in the area. In addition, healthcare providers should focus on information dissemination on proper latrine utilization, and washing the face regularly to prevent active trachoma infection is highly recommended.
Common clinicopathological and immunological features of sarcomatoid carcinoma across organs: A histomorphology‐based cross‐organ study
Authors: Morisue Ryo , Kojima Motohiro , Suzuki Toshihiro , Watanabe Reiko , Sakamoto Naoya , Sakashita Shingo , Harada Kenji , Nakai Tokiko , Ishii Genichiro , Nakatsura Tetsuya , Gotohda Naoto , Ishikawa Shumpei 
Published: August 2023

AbstractSarcomatoid carcinoma (SC), which can occur in any organ, is a rare disease. To elucidate common characteristics of SC beyond organs, we evaluated clinicopathological and immunological features of SC defined by the single histological criterion beyond organs compared to randomly matched conventional carcinoma (non‐SC) adjusted for the disease stage. Immunological features were assessed by multiplex immunohistochemistry, comparing immune cell density in tumor tissues and tumor programmed death‐ligand 1 (PD‐L1) expression. A total of 101 patients with SC or non‐SC (31 lung, 19 esophagus, 22 pancreas, 15 liver, 4 bile duct, 6 kidney, 2 uterus and 2 ovary) were identified among 7197 patients who underwent surgery at our institute (1997‐2020). SC was significantly associated with worse survival (HR: 1.571; 95% CI: 1.084‐2.277; P = .017). The frequency of postoperative progression within 6 months was significantly higher for SC patients (54% vs 28%; P = .002). The immune profiling revealed the densities of CD8+ T cells (130 vs 72 cells/mm2; P = .004) and tumor‐associated macrophages (566 vs 413 cells/mm2; P < .0001) and the tumor PD‐L1 expression score (40% vs 5%; P < .0001) were significantly higher in SCs than in non‐SCs. Among 73 SC patients with postoperative progression, multivariate Cox regression analysis showed that immunotherapy tended to be associated with favorable survival (HR: 0.256; 95% CI: 0.062‐1.057; P = .060). Collectively, SCs shared clinicopathological and immunological features across organs. Our study can initiate to standardize the pathological definition of SC and provide a rationale for the investigation and development for this rare disease in a cross‐organ manner.
Learning with the stars: A cross‐national approach to media literacy and reality television
Authors: Rao Dingxin , Lee Changhee , Dressman Mark 
Published: August 2023

AbstractReality television (RT) programming is frequently and rightfully criticized and yet its popularity among adolescent and young adult viewers is also undeniable. In response to the need for media literacy programs to address the pleasures, the problems, and the pedagogy of the genre, we have chosen to take a cross‐national, comparative approach and to model a process for teaching through our own research. Three popular reality tv programs were selected from each of our respective nations (China, South Korea, the United States) from one of three subgenres: Dancing, Restaurants, and Travel. We each watched episodes of all nine programs, inventoried their features and took notes. We then compared and contrasted the programs cross‐nationally and across genres, and identified four themes: Pedagogy; Individualism and Collectivism; Tradition and Modernity; and Globalism and Nationalism. We found striking differences across nations in our analysis that provide important insights into our respective national cultures. In conclusion, we discuss the implications of our process for teaching about RT.
Circ_0006324 regulates cell proliferation, cell‐cycle progression, apoptosis, and glycolysis of non‐small cell lung cancer cells through miR‐496/TRIM59 axis
Authors: Wang Tao , Zhu Xu , Wang Kai , Ding Ronghai 
Published: August 2023

AbstractIncreasing evidence suggests that circular RNA (circRNA) plays an important role in non‐small cell lung cancer (NSCLC) progression. This study aimed to investigate the role and potential molecular mechanism of circ_0006324 in NSCLC. The expression levels of circ_0006324, miR‐496, miR‐488‐5p, and tripartite motif‐containing 59 (TRIM59) mRNA were determined by quantitative real‐time polymerase chain reaction (PCR). 3‐(4,5‐dimethyl‐2‐thiazolyl)‐2,5‐diphenyl‐2‐H‐tetrazolium bromide assay, EdU assay, and flow cytometry were carried out to evaluate cell proliferation and apoptosis. The extracellular acidification rate and lactic acid production were examined to assess cell glycolysis. Western blot assay was used to detect protein levels. The target relationship of circ_0006324/miR‐496/TRIM59 axis was validated by RNA pull‐down assay, dual luciferase reporter assay, and radio immunoprecipitation assay. Xenograft tumor assay was performed to reveal the function of circ_0006324 in vivo. Circ_0006324 was upregulated in NSCLC and related to tumor node metastasis stage and distant metastasis. Knockdown of circ_00006324 impeded NSCLC cell proliferation, glycolysis, and promoted cell apoptosis. MiR‐496 was verified as a target of circ_0006324 and circ_00006324 mediated the altering of cell proliferation, apoptosis, and glycolysis of NSCLC cells through targeting miR‐496. TRIM59 was verified as a target of miR‐496, and circ_0006324 positively regulated TRIM59 expression by targeting miR‐496. Overexpression of TRIM59 could reverse the effects of circ_0006324 silencing on the proliferation, apoptosis, and glycolysis of NSCLC cells. Circ_0006324 knockdown impeded NSCLC tumor growth in vivo. Circ_0006324 functioned as a tumor promoter in NSCLC to promote cell proliferation, cell cycle progression, and glycolysis and inhibit cell apoptosis via miR‐496/TRIM59 axis.
Turán numbers T(n,5,3) $T(n,5,3)$ and graphs without induced 5‐cycles
Authors: Bluskov Iliya , Heer Jan de , Sidorenko Alexander 
Published: August 2023

AbstractThe Turán number is the minimum size of a system of triples out of a base set of elements such that every quintuple in contains a triple from the system. The exact values of are known for . Turán conjectured that , and no counterexamples have been found so far. If this conjecture is true, then . We prove the matching upper bound for all except .
Review of Hyperpolarized Pulmonary Functional 129Xe MR for Long‐COVID
Authors: Wild Jim M. , Gleeson Fergus V. , Svenningsen Sarah , Grist James T. , Saunders Laura C. , Collier Guilhem J. , Sharma Maksym , Tcherner Sam , Mozaffaripour Ali , Matheson Alexander M. , Parraga Grace 
Published: August 2023

The respiratory consequences of acute COVID‐19 infection and related symptoms tend to resolve 4 weeks post‐infection. However, for some patients, new, recurrent, or persisting symptoms remain beyond the acute phase and persist for months, post‐infection. The symptoms that remain have been referred to as long‐COVID. A number of research sites employed 129Xe magnetic resonance imaging (MRI) during the pandemic and evaluated patients post‐infection, months after hospitalization or home‐based care as a way to better understand the consequences of infection on 129Xe MR gas‐exchange and ventilation imaging. A systematic review and comprehensive search were employed using MEDLINE via PubMed (April 2023) using the National Library of Medicine's Medical Subject Headings and key words: post‐COVID‐19, MRI, 129Xe, long‐COVID, COVID pneumonia, and post‐acute COVID‐19 syndrome. Fifteen peer‐reviewed manuscripts were identified including four editorials, a single letter to the editor, one review article, and nine original research manuscripts (2020–2023). MRI and MR spectroscopy results are summarized from these prospective, controlled studies, which involved small sample sizes ranging from 9 to 76 participants. Key findings included: 1) 129Xe MRI gas‐exchange and ventilation abnormalities, 3 months post‐COVID‐19 infection, and 2) a combination of MRI gas‐exchange and ventilation abnormalities alongside persistent symptoms in patients hospitalized and not hospitalized for COVID‐19, 1‐year post‐infection. The persistence of respiratory symptoms and 129Xe MRI abnormalities in the context of normal or nearly normal pulmonary function test results and chest computed tomography (CT) was consistent. Longitudinal improvements were observed in long‐term follow‐up of long‐COVID patients but mean 129Xe gas‐exchange, ventilation heterogeneity values and symptoms remained abnormal, 1‐year post‐infection. Pulmonary functional MRI using inhaled hyperpolarized 129Xe gas has played a role in detecting gas‐exchange and ventilation abnormalities providing complementary information that may help develop our understanding of the root causes of long‐COVID.Level of Evidence1Technical EfficacyStage 5
The high prevalence of occult hepatitis B infections among the partners of chronically infected HBV blood donors emphasizes the potential residual risk to blood safety
Authors: Ye Xianlin , Li Tong , Yu Binghuan , Zeng Jinfeng , Shi Yaoqiang , Xie He , Branch Donald R. , Loriamini Melika , Li Bin , Chen Limin 
Published: August 2023

AbstractA small percentage of couples who regularly donated blood in China tested positive for HBsAg. Although it is well known that blood donors can acquire hepatitis B virus (HBV) infection from a chronically infected sexual partner, the prevalence of occult hepatitis B infections (OBIs) among blood donations from partners of HBV‐infected chronically infected spouses and the risk to blood safety remain poorly understood. Among 212 763 blood donors, 54 pairs of couples (108 donations) were enrolled because one partner tested positive for HBsAg. Several molecular and serological examinations were conducted. The origin of HBV transmission between sexual partners was investigated further. Also evaluated was the potential risk of HBV infection with OBIs. We identified 10 (10/54, 18.6%) sexual partners of chronically infected HBV donors who were positive for HBV DNA, including five samples (9.3%) with OBIs, of which 3 (3/54, 5.6%, 1 in 70 921 donations) passed the routine blood screening tests. Seven of the 10 HBV‐DNA‐positive couples contracted the virus possibly through sexual or close contact. Among infected couples, immune escape mutations were observed. A high prevalence of OBIs was found among the partners of chronically infected HBV blood donors, posing a potential threat to blood safety.
The short and long‐term impact of nonpharmaceutical interventions on the prevalence of varicella in Xi'an during the COVID‐19 pandemic
Authors: Bai Yao , Shen Li , Sun Minghao , Yang Zurong , Chen Zhijun , Zhai Jingbo , Xue Mengzhou , Shao Zhongjun , Liu Kun , Zheng Chunfu 
Published: August 2023

AbstractVaricella is a highly prevalent infectious disease with a similar transmission pathway to coronavirus disease 2019 (COVID‐19). In the context of the COVID‐19 pandemic, anti‐COVID‐19 nonpharmaceutical interventions (NPIs) have been implemented to prevent the spread of the infection. This study aims to analyze varicella's epidemiological characteristics and further investigate the effect of anti‐COVID‐19 NPIs on varicella in Xi'an, northwestern China. Based on the varicella surveillance data, search engine indices, meteorological factors from 2011 to 2021 in Xi'an, and different levels of emergency response to COVID‐19 during the pandemic, we applied Bayesian Structural Time Series models and interrupted time series analysis to predict the counterfactual incidence of varicella and quantify the impact of varying NPIs intensities on varicella. From 2011 to 2021, varicella incidence increased, especially in 2019, with a high incidence of 111.69/100 000. However, there was a sharp decrease of 43.18% in 2020 compared with 2019, and the peak of varicella incidence in 2020 was lower than in previous years from the 21st to the 25th week. In 2021, the seasonality of varicella incidence gradually returned to a seasonal pattern in 2011–2019. The results suggest that anti‐COVID‐19 NPIs effectively reduce the incidence of varicella, and the reduction has spatiotemporal heterogeneity.
A national survey of helping professionals on climate change and counseling
Authors: Reese Ryan F. , Swank Jacqueline M. , Sturm Debbie C. 
Published: August 2023

AbstractWe surveyed a national sample of helping professionals (N = 382) in ascertaining attitudes toward, behaviors related to, and needs for addressing climate change as part of counseling. Two factors of EcoWellness and a helping professional's personal commitment to climate change contributed to a professional commitment to addressing climate change in counseling.
The gene AccCyclin H mitigates oxidative stress by influencing trehalose metabolism in Apis cerana cerana
Authors: Peng Hongyan , Guo Dezheng , Peng Hongmei , Guo Hengjun , Wang Hongfang , Wang Ying , Xu Baohua , Gao Aiying , Liu Zhenguo , Guo Xingqi 
Published: August 2023

AbstractBACKGROUNDEnvironmental stress can induce oxidative stress in Apis cerana cerana, leading to cellular oxidative damage, reduced vitality, and even death. Currently, owing to an incomplete understanding of the molecular mechanisms by which A. cerana cerana resists oxidative damage, there is no available method to mitigate the risk of this type of damage. Cyclin plays an important role in cell stress resistance. The aim of this study was to explore the in vivo protection of cyclin H against oxidative damage induced by abiotic stress in A. cerana cerana and clarify the mechanism of action. We isolated and identified the AccCyclin H gene in A. cerana cerana and analysed its responses to different exogenous stresses.RESULTSThe results showed that different oxidative stressors can induce or inhibit the expression of AccCyclin H. After RNA‐interference‐mediated AccCyclin H silencing, the activity of antioxidant‐related genes and related enzymes was inhibited, and trehalose metabolism was reduced. AccCyclin H gene silencing reduced A. cerana cerana high‐temperature tolerance. Exogenous trehalose supplementation enhanced the total antioxidant capacity of A. cerana cerana, reduced the accumulation of oxidants, and improved the viability of A. cerana cerana under high‐temperature stress.CONCLUSIONOur findings suggest that trehalose can alleviate adverse stress and that AccCyclin H may participate in oxidative stress reactions by regulating trehalose metabolism. © 2023 Society of Chemical Industry.
Antioxidants ameliorate oxidative stress in alcoholic liver injury by modulating lipid metabolism and phospholipid homeostasis
Authors: Wang Xiaoxu , Liu Bin , Liu Yanjun , Wang Yuliu , Wang Zhigao , Song Yu , Xu Jie , Xue Changhu 
Published: August 2023

AbstractAlcoholic liver disease (ALD) is a significant risk factor in the global disease burden. The antioxidants vitamin C (Vc) and N‐acetyl cysteine (NAC) have shown hepatoprotective effects in preventing and treating ALD. However, the correlation between the improved effect of antioxidants and lipid metabolism is still unclear. In this study, AML12 cells and C57BL/6 mice stimulated with alcohol were used to investigate the protective effects and potential mechanisms of two antioxidants (Vc and NAC) on alcoholic liver injury. Results showed that Vc and NAC attenuated intracellular lipid accumulation and oxidative damage induced by excessive alcohol exposure in hepatic AML12 cells. The in vivo results indicated that antioxidants ameliorated alcohol‐induced changes in histopathology, reducing the levels of alcohol metabolizing factors and aspartate aminotransferase (AST), alanine aminotransferase (ALT), triglyceride (TG), and total cholesterol (TC) contents, which demonstrated that antioxidants effectively mitigated liver injury in ALD mice. Further studies showed that antioxidants reversed the disruption of fatty acid (FA) synthesis and lipid transport induced by alcohol exposure, and restored phospholipid levels. Especially, Vc and NAC increased the endogenous antioxidant plasmenyl phosphatidylethanolamine (PlsEtn). Additionally, antioxidants ameliorated the alcohol‐impaired mitochondrial function and inhibited excessive oxidative stress. In conclusion, antioxidants can regulate lipid metabolism and phospholipid homeostasis, which in turn inhibit oxidative stress and thereby exert protective effects against ALD.
Validity of the Landsat surface reflectance archive for aquatic science: Implications for cloud‐based analysis
Authors: Maciel Daniel Andrade , Pahlevan Nima , Barbosa Claudio Clemente Faria , de Novo Evlyn Márcia Leão de Moraes , Paulino Rejane Souza , Martins Vitor Souza , Vermote Eric , Crawford Christopher J. 
Published: August 2023

AbstractOriginally developed for terrestrial science and applications, the US Geological Survey Landsat surface reflectance (SR) archive spanning ~ 40 yr of observations has been increasingly utilized in large‐scale water‐quality studies. These products, however, have not been rigorously validated using in situ measured reflectance. This letter quantifies and demonstrates the quality of the SR products by harnessing a sizeable global dataset (N = 1100). We found that the Landsat 8/9 SR in the green and red bands marginally meet the targeted accuracy requirements (30%), whereas the uncertainties in the blue and coastal‐aerosol bands ranged from 48% to 110%. We further observed > +25% biases in the visible bands of Landsat 5/7 SR, which can introduce an apparent downward trend when applied in time‐series analyses combined with Landsat 8/9. Users must exercise caution when using this archive for trend analyses, and progress in atmospheric correction is required to foster advanced applications of the Landsat archive for aquatic science.