bluuebunny/crossref_metadata_2025_split huggingface dataset:
Excellent leukemia control after second hematopoietic cell transplants with unrelated cord blood grafts for post-transplant relapse in pediatric patients
Authors: Troullioud Lucas Alexandre G. , Boelens Jaap Jan , Prockop Susan E. , Curran Kevin J. , Bresters Dorine , Kollen Wouter , Versluys Birgitta , Bierings Marc B. , Archer Anne , Davis Eric , Klein Elizabeth , Kernan Nancy A. , Lindemans Caroline A. , Scaradavou Andromachi 
Published: August 2023

BackgroundPatients with leukemia relapse after allogeneic hematopoietic cell transplant (HCT) have poor survival due to toxicity and disease progression. A second HCT often offers the only curative treatment.MethodsWe retrospectively reviewed our bi-institutional experience (MSKCC-USA; Utrecht-NL) with unrelated cord blood transplantation (CBT) for treatment of post-transplant relapse. Overall survival (OS) and event-free survival (EFS) were evaluated using the Kaplan-Meier method, treatment-related mortality (TRM) and relapse were evaluated using the competing risk method by Fine-Gray.ResultsTwenty-six patients age &lt; 21 years received a second (n=24) or third (n=2) HCT with CB grafts during the period 2009-2021. Median age at first HCT (HCT1) was 11.5 (range: 0.9-17.7) years and all patients received myeloablative cytoreduction. Median time from HCT1 to relapse was 12.8 (range 5.5-189) months. At CBT, median patient age was 13.5 (range 1.4-19.1) years. Diagnoses were AML: 13; ALL: 4, MDS: 5, JMML: 2; CML: 1; mixed phenotype acute leukemia: 1. Sixteen patients (62%) were in advanced stage, either CR&gt;2 or with active disease. Median time from HCT1 to CBT was 22.2 (range 7-63.2) months. All patients engrafted after CBT. Thirteen patients developed acute GvHD; 7 had grade III or IV. With a median survivor follow-up of 46.6 (range 17.4-155) months, 3-year OS was 69.2% (95% CI 53.6-89.5%) and 3-year EFS was 64.9% (95% CI 48.8-86.4%). Eight patients died, 3 of AML relapse and 5 due to toxicity (respiratory failure [n=4], GvHD [n=1]) at a median time of 7.7 (range 5.9-14.4) months after CBT. Cumulative incidence of TRM at 3 years was 19.2% (95% CI 4.1-34.4%). Notably, all TRM events occurred in patients transplanted up to 2015; no toxicity-related deaths were seen in the 16 patients who received CBT after 2015. Cumulative incidence of relapse was 15.9% (95% CI 1.6-30.2%) at 3 years, remarkably low for these very high-risk patients.ConclusionsSurvival was very encouraging following CB transplants in pediatric patients with recurrent leukemia after first HCT, and TRM has been low over the last decade. CBT needs to be strongly considered as a relatively safe salvage therapy option for post-transplant relapse.
Effect of acupuncture inclusion in the enhanced recovery after surgery protocol on tumor patient gastrointestinal function: a systematic review and meta-analysis of randomized controlled studies
Authors: Chen Jiu , Fu Tianxiao , Liu Li , Xie Yirui , Li Youdi 
Published: August 2023

IntroductionAcupuncture has been shown to be effective in restoring gastrointestinal function in tumor patients receiving the enhanced recovery after surgery (ERAS) protocol. The present systematic review and meta-analysis aimed to evaluate the rationality and efficacy of integrating acupuncture in the ERAS strategy to recuperate gastrointestinal function.MethodsWe searched eleven databases for relevant randomized clinical trials (RCTs) of acupuncture for the treatment of gastrointestinal dysfunction in tumor patients treated with the ERAS protocol. The quality of each article was assessed using the Cochrane Collaboration risk of bias criteria and the modified Jadad Scale. As individual symptoms, the primary outcomes were time to postoperative oral food intake, time to first flatus, time to first distension and peristaltic sound recovery time (PSRT). Pain control, adverse events, and acupoint names reported in the included studies were also investigated.ResultsOf the 211 reviewed abstracts, 9 studies (702 patients) met eligibility criteria and were included in the present systematic review and meta‑analysis. Compared to control groups, acupuncture groups showed a significant reduction in time to postoperative oral food intake [standardized mean difference (SMD) = -0.77, 95% confidence interval (CI) -1.18 to -0.35], time to first flatus (SMD=-0.81, 95% CI -1.13 to -0.48), time to first defecation (SMD=-0.91, 95% CI -1.41 to -0.41, PSRT (SMD=-0.92, 95% CI -1.93 to 0.08), and pain intensity (SMD=-0.60, 95% CI -0.83 to -0.37).The Zusanli (ST36) and Shangjuxu (ST37) acupoints were used in eight of the nine included studies. Adverse events related to acupuncture were observed in two studies, and only one case of bruising was reported. DiscussionThe present systematic review and meta‑analysis suggested that acupuncture significantly improves recovery of gastrointestinal function and pain control in tumor patients receiving the ERAS protocol compared to the control group. Moreover, ST36 and ST37 were the most frequently used acupoints. Although the safety of acupuncture was poorly described in the included studies, the available data suggested that acupuncture is a safe treatment with only mild side effects. These findings provide evidence-based recommendations for the inclusion of acupuncture in the ERAS protocol for tumor patients.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/ PROSPERO, identifier CRD42023430211.
The combined effects of coping and pain interference on army readiness
Authors: Kegel Jessica L. , Kazman Josh B. , Clifton Daniel R. , Emanuele Peter , Nelson D. Alan , Deuster Patricia A. 
Published: August 2023

IntroductionChronic pain and associated interference with daily activities are common in the military and impact Force readiness. Chronic pain affects one-third of service members and is a leading cause of medical non-readiness (MNR) in the military. Research suggests that underlying psychological mechanisms related to trait coping styles and pain interference (PI) affect functional outcomes, but little research exists examining this relationship within an Army population. The purpose of this study was to examine the combined effects of PI and coping on U.S. Army soldier readiness by using annual well-being data from the Global Assessment Tool (GAT) and medical non-readiness (MNR) based on duty restriction records.MethodsThe sample comprised 866,379 soldiers who completed the GAT between 2014 and 2017 with no duty restrictions at the time of baseline GAT completion; subjects were observed through 2018 for duty restrictions. Parametric survival regression models with a Weibull distribution predicted demographic-adjusted hazards of MNR by dichotomized PI (no PI/PI) and beneficial/non-beneficial use of GAT coping components (good coping, bad coping, catastrophizing-flexibility, and catastrophizing-hopelessness). Incident MNR was evaluated for all duty restrictions, and stratified by selected body systems (upper extremity, lower extremity, psychiatric).ResultsAmong soldiers with PI, hazards were higher in those reporting non-beneficial coping styles (bad coping, hopelessness) and lower in those reporting beneficial coping styles (good coping, flexibility). Across all coping styles, PI/coping interactions were particularly strong for catastrophizing-hopelessness and when examining MNR from psychiatric conditions.DiscussionThese findings suggest some synergistic associations between pain and coping that may impact pain-related occupational disability. Coping skills may be an effective interventional target for chronic pain reduction/prevention within military programs, such as the Master Resilience Training Course offered to soldiers in the Army. Further research should assess whether early coping style interventions can reduce pain-related outcomes.
Improvement in medical students’ knowledge on chronic pain assessment through integrative learning approaches: a randomized controlled trial
Authors: Soenarto Ratna Farida , Sukmono Besthadi , Findyartini Ardi , Susilo Astrid Pratidina 
Published: August 2023

IntroductionThis study aimed to compare the knowledge and skills of medical students in chronic pain assessment after being trained using the PQRST (P, provoke and palliate; Q, quality; R, region and radiation; S, severity; T, time) and ACT-UP (A, activity; C, coping; T, think; U, upset; P, people) mnemonics with those using only the PQRST mnemonic.MethodsA double-blind, randomized controlled trial was conducted at the Faculty of Medicine, Universitas Indonesia, including forty students who participated in a simulation-based chronic pain assessment workshop. Pre- and post-test scores were used to assess participants’ knowledge. Two independent raters assessed the students’ skills.ResultsNo significant differences in knowledge or skills were observed between the groups; however, a significant improvement in the post-test scores (85.71 [71.43–95.24]) compared to the pre-test scores (61.90 [25.87–90.48]) was observed. The students reported high satisfaction with the workshop.ConclusionsTraining with the PQRST and ACT-UP mnemonics is not better than training with the PQRST mnemonic alone in improving students’ knowledge and skills in chronic pain assessment. Nevertheless, this pain education workshop was beneficial for student learning. Learning of patient-oriented chronic pain assessment should be provided in a repetitive and integrative fashion using different approaches, such as lectures, demonstrations, simulations, and interactions with patients experiencing chronic pain. To conclude, mnemonics are helpful but not a primary learning tool.
Relationship between cerebral oxygenation, cardiac output, and blood pressure during transitional period in extremely low gestational age neonates
Authors: Deshpande Poorva , Barbosa de Olivera Caio , Jain Amish , Hahn Cecil , Shah Prakesh S. , Guerguerian Anne-Marie , McNamara Patrick J. 
Published: August 2023

ObjectiveTo describe the relationship between cerebral oxygenation, cardiac output, arterial blood pressure (BP), and cerebral blood flow velocity in extremely low gestational age neonates (ELGANs) during transition.MethodsThis study comprises secondary analyses from a prospective observational study conducted at a tertiary Neonatal Intensive Care Unit. Recruited ELGANs underwent cerebral saturation (CrSO2) monitoring and serial echocardiography during 72 h from birth. Correlative analyses of CrSO2 and cerebral fractional tissue oxygen extraction (CFTOE) with left (LVO) and right ventricular output (RVO), superior vena cava (SVC) flow, middle cerebral artery blood flow mean velocity (MCA.MV), systolic (SBP), diastolic (DBP), and mean (MBP) BP were conducted.ResultsFifty ELGANs with median (range) gestational age of 25.9 (23.1–27.9) weeks were recruited. Echocardiography was performed sequentially at a median (range) age 5.0 (3.8–6.6), 17.3 (15.4–19.4), 31.0 (27.0–34.1), and 53.7 (49.3–58.3) hours. RVO, LVO, CrSO2, and SBP increased over time but no changes in MBP, DBP, CFTOE, MCA.MV or SVC flow were noted. A weak correlation was identified between CrSO2 and SBP (r2 = 0.11, p = 0.047) and MBP (r2 = 0.12, p = 0.04) at 17.3 (15.4–19.4) hours. No correlation of either CrSO2 or CFTOE with any measures of blood flow was identified.ConclusionThere is a weak correlation between measures of cardiac output, BP, and MCA.MV with both CrSO2 and CFTOE in ELGANs during transition. Whether this finding suggests intact cerebral autoregulation requires prospective evaluation in a cohort of sick ELGANs.
Defining and supporting a professional role for pharmacists associated with traditional and complementary medicines: a cross-country survey of pharmacists
Authors: Harnett Joanna E. , Desselle Shane P. , Fernandes Marcília Baticy , Yao Dongning , Modun Darko , Hallit Souheil , Dabbous Mariam , Wahab Mohd Shahezwan Abd , Cavaco Afonso Miguel , Magalhães Maria , Faller Erwin Martinez , Flores Jennifer M. , Gabriel Jacklyn Risia D. San , Othman Noordin , Anantachoti Puree , Sriboonruang Tatta , Sriviriyanupap Wanna , Alnezary Faris , Alahmadi Yaser , Fallatah Saad Bakur , Fadil Haifa Abdulrahman , Ung Carolina Oi Lam 
Published: August 2023

Introduction: An estimated 80% of the world’s population use traditional and complementary medicine (T&amp;CM) products as part of their healthcare, with many accessed through pharmacy. This cross-cultural study posed a set of professional practice responsibilities and actions to pharmacists related to T&amp;CM products, with a view toward developing consensus, safeguarding, and promoting the health of the public.Methods: Data were collected from 2,810 pharmacists across nine countries during 2022 via a cross-sectional online survey reported in accordance with the guidelines of STrengthening the Reporting of OBservational studies in Epidemiology (STROBE) and the Checklist for Reporting Results of Internet E-Surveys (CHERRIES).Results: Of the 2,810 participants from nine countries, 2,341 completed all sections of the survey. Of these, most agreed (69%) that T&amp;CM product use was common in the community they served, but most did not have adequate training to support consumer needs. Over 75% acknowledged that there were known and unknown safety risks associated with T&amp;CM use. Of 18 professional responsibilities posed, 92% agreed that pharmacists should be able to inform consumers about potential risks, including T&amp;CM side effects and drug–herb interactions. The provision of accurate scientific information on the effectiveness of T&amp;CM products, skills to guide consumers in making informed decisions, and communication with other healthcare professionals to support appropriate and safe T&amp;CM product use were all ranked with high levels of agreement. In order to effectively fulfill these responsibilities, pharmacists agreed that regulatory reforms, development of T&amp;CM education and training, and access to quality products supported by high-quality evidence were needed.Conclusion: General agreement from across nine countries on eighteen professional responsibilities and several stakeholder actions serve as a foundation for the discussion and development of international T&amp;CM guidelines for pharmacists.
Alterations in executive functions in inmates convicted for violent behavior: a systematic review
Authors: Chaguendo-Quintero Maria Antonia , Quintero-Monjes Daniela , Cuervo Maria Teresa , Sanabria-Mazo Juan P. 
Published: August 2023

BackgroundThe growth of the prison population and the high recidivism rates of inmates represent a major public safety problem.ObjectiveThis systematic review explored executive functions in inmates convicted of violent behavior compared with inmates convicted of non-violent behavior and healthy controls (HCs).MethodsSystematic searches were carried out using five databases (PubMed, Scopus, Web of Science, EBSCO, and Embase) until March 6th, 2023. Following Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines, two reviewers independently performed the screening, data extraction, and risk of bias assessment of the 8 studies included. The protocol of this study was registered in Prospective Register of Systematic Reviews (PROSPERO), under registration number CRD42021252043.ResultsConsistently, inmates convicted of violent behavior exhibited a greater alteration in inhibition than inmates convicted of non-violent behavior (four out of four studies) and HCs (two out of two studies). In addition, inmates convicted of violent behavior showed greater impairments in cognitive flexibility (two out of three studies) and working memory (two out of three studies) than HCs. Although with limited evidence (only one study), they also showed worse performance in set shifting and planning than HCs.ConclusionThis study provides evidence of alterations in inhibition in inmates convicted of violent behavior compared to inmates convicted of non-violent behavior and HCs. Even though inmates convicted of violent behavior showed greater impairments in planning and set shifting than HCs, these findings were supported in only one study. In general, more robust evidence is needed to confirm alterations in inmates convicted due to violent behavior. These findings highlight the importance of designing and promoting specific cognitive interventions that contribute to the reintegration of inmates into society.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021252043, identifier CRD42021252043.
A systematic review of Clinical Practice Guidelines for the development of the WHO's Package of Interventions for Rehabilitation: focus on schizophrenia
Authors: Serra Riccardo , Etemadi Yasaman , van Regteren Altena Marieke , Barbui Corrado , Tarsitani Lorenzo 
Published: August 2023

BackgroundThe identification of interventions for rehabilitation and related evidence is a crucial step in the development of World Health Organization's (WHO) Package of Interventions for Rehabilitation (PIR). Interventions for rehabilitation may be particularly relevant in schizophrenia, as this condition is associated with a high risk of disability, poor functioning, and lack of autonomy. Aiming to collect evidence for the WHO PIR, we conducted a systematic review of Clinical Practice Guidelines (CPG) on interventions for rehabilitation of schizophrenia.MethodsMethods for the systematic identification and critical appraisal of CPG were developed by WHO Rehabilitation Programme and Cochrane Rehabilitation under the guidance of WHO's guideline review committee secretariat. The Appraisal of Guidelines for Research &amp; Evaluation Instrument (AGREE II) was used to evaluate the methodological quality of identified CPG.ResultsAfter full text screening, nine CPG were identified, for a total of 130 recommendations. Three were excluded because their total AGREE-II scores were below cut-off. Six CPG were approved by the Technical Working Group and included for data extraction. Only one CPG with specific focus on rehabilitation of schizophrenia was retrieved. Other CPG were general, including some recommendations on rehabilitation. Some CPG gave no indications on the assessment of rehabilitation needs. Discrepancies were detectable, with different CPG emphasizing different domains. Most recommendations addressed “symptoms of schizophrenia,” while “community and social life” was targeted by few recommendations. International CPG were often conceptualized for high-income countries, and CPG accounting for their implementation in lower income contexts were scarce. Quality of evidence was high/moderate for 41.54% (n = 54) of the recommendations, and very low only in two cases (1.52%). N = 45 (34.62%) were based on experts' opinion.ConclusionsThe concepts of recovery and rehabilitation in schizophrenia are relatively new in medical sciences and somewhat ill-defined. An unbalanced distribution in the domains addressed by available CPG is therefore understandable. However, the need for more focus in some areas of rehabilitation is obvious. More clarity is also required regarding which interventions should be prioritized and which are more feasible for global implementation in the rehabilitation of schizophrenia.
POLITIK HUKUM KETENTUAN BATAS USIA PERKAWINAN DALAM UU. NO 01 TAHUN 1974 TENTANG PERKAWINAN
Authors: Suhaili Achmad , Aziz Abd 
Published: August 2023

Hukum adalah instrumentasi dari putusan atau keinginan politik, sehingga pembuatan undang-undang sarat dengan kepentingan-kepentingan tertentu, dan dengan demikian medan pembuatan undang-undang menjadi medan perbenturan dan pergumulan kepentingan-kepentingan. Badan pembuat undang-undang akan mencerminkan konfigurasi kekuatan dan kepentingan yang ada dalam masyarakat. Konfigurasi kekuatan dan kepentingan dalam badan pembuat undang-undang menjadi penting karena pembuatan undang-undang modern bukan sekadar merumuskan materi hukum secara baku berikut rambu-rambu yuridisnya, melainkan membuat putusan politik terlebih dahulu. Berdasarkan hal tersebut diatas sangat penting mengkaji politik hukum batas usia perkawinan dalam UU No 01 tahun 1974 tentang perkawinan. Secara politis bunyi dari UU Perkwainan Tahun 1974 itu memiliki nilai-nilai yang positif demi menjaga kemaslahatan perkawinan itu, misalnya bagi yang belum berusia 21 tahun harus mendapat izin dari orang tua, batas usia minimal boleh kawin adalah 19 tahun untuk pria dan 16 tahun untuk wanita merupakan usaha untuk mencegah terjadinya kerusakan dalam membina rumah tangga nantinya, karena usia di bawah 21 tahun bisa dikatakan usia belum matang untuk melaksanakan dan membina rumah tangga. Kemudian dengan pembatasan usia dalam perkawinan tersebut tentunya akan membawa nilai kemaslahatan bagi yang bersangkutan. Adapun tujuan pembatasan perkawinan secara politik hukum adalah untuk pembangunan kualitas sumber daya manusia berdasarkan kepentingan individu, organisasi, kepentingan nasional dan untuk kebutuhan pada masa yang akan dating.
Study of ground state magnetic structure of L10-type MnAl via spin-spiral density wave
Authors: Yamashita Shogo , Sakuma Akimasa 
Published: August 2023

Abstract
We investigated the ground state magnetic structure of L10-type MnAl with the density functional theory via the spin-spiral density wave state. Our results indicate that stoichiometric perfectly ordered MnAl prefers an antiferromagnetic state, while the ferromagnetic state is metastable. When a chemical disorder is introduced with the degree of order S = 0.9, the spiral period becomes longer than that of the antiferromagnetic structure, and below S = 0.8, the system adopts the ferromagnetic state. Furthermore, doping of Mn atoms into the Al sites above 5 at% led to the ferromagnetic state. We confirmed that chemical or compositional disorder induces ferromagnetic transitions in MnAl alloys.
Pedagogical Transformation: Effects of Open Educational Resources on Teaching in Higher Institutions of Learning in Kenya
Authors: Muthanga Beatrice Nyambura , Maku Paul Gichohi , Ogalo James Ochieng 
Published: August 2023

OERs are viewed as providing chances to provide access to high-quality educational and informational materials globally in this age of digitization. By enabling access to digital materials, academic institutions are utilizing the technological revolution to transform teaching and research. With the removal of financial, legal, and technical barriers, more academic institutions and faculty members are now able to access digital materials online, transforming teaching and research on a global scale. OERs have made it possible to offer accessible and free information resources for everyone in the academic setting since they are affordable and customizable. When aiming at certain audiences, the capacity to adapt and adjust material offers a significant benefit. The growing need for instructional materials and learning tools in contrast to the dire budgetary circumstances at many institutions. The purpose of this study is to review pedagogical transformation effects of Open Educational Resources on teaching in higher institutions of learning in Kenya.