bluuebunny/crossref_metadata_2025_split huggingface dataset:
Renormalization of Very Special Relativity gauge theories
Authors: Alfaro J. 
Published: June 2023

Abstract
Mandelstam-Leibbrandt (ML) regularization of Very Special Relativity (VSR) amplitudes in momentum space depends on two fixed null vectors nμ, $$ {\overline{n}}_{\mu } $$

n
¯

μ

besides external momenta. ML is known to preserve gauge invariance and naive power counting. The second null vector $$ {\overline{n}}_{\mu } $$

n
¯

μ

destroys the Sim(2) symmetry of the VSR model. We devise a systematic procedure to take the $$ {\overline{n}}_{\mu } $$

n
¯

μ

→ 0 limit to recover the lost Sim(2) symmetry. The procedure produces Sim(2) and gauge invariant loop amplitudes. We show how to use this method to remove unphysical terms from the Non Relativistic Potential of Very Special Relativity Quantum Electrodynamics (VSR QED) with a massive photon. Then we compute the one loop renormalization of VSR QED. Finally we derive the anomalous magnetic moment of the electron, modified by neutrino and photon mass; and comments on the phenomenological implications.
Mitochondria as central hubs in synaptic modulation
Authors: Duarte Filipe V. , Ciampi Daniele , Duarte Carlos B. 
Published: June 2023

AbstractMitochondria are present in the pre- and post-synaptic regions, providing the energy required for the activity of these very specialized neuronal compartments. Biogenesis of synaptic mitochondria takes place in the cell body, and these organelles are then transported to the synapse by motor proteins that carry their cargo along microtubule tracks. The transport of mitochondria along neurites is a highly regulated process, being modulated by the pattern of neuronal activity and by extracellular cues that interact with surface receptors. These signals act by controlling the distribution of mitochondria and by regulating their activity. Therefore, mitochondria activity at the synapse allows the integration of different signals and the organelles are important players in the response to synaptic stimulation. Herein we review the available evidence regarding the regulation of mitochondrial dynamics by neuronal activity and by neuromodulators, and how these changes in the activity of mitochondria affect synaptic communication.
Stoichiometric characteristics and homeostasis of leaf nitrogen and phosphorus responding to different water surface elevations in hydro-fluctuation zone of the Three Gorges Reservoir
Authors: Wang Heyun , Sun Tong , Liu Ying , Liu Wei , Xiao Henglin 
Published: June 2023

AbstractAs a type of wetland ecosystem with off-season 30 m water level fluctuation, the huge changes in the ecological environment, plant species, and vegetation dynamics in the hydro-fluctuation zone of the Three Gorges Reservoir (TGR) area have attracted a wide range of attention. In this present study, six typical locations in the water level fluctuating zone were used as the research objects, and the effects of different water surface elevations on the stoichiometric characteristics and homeostasis of leaf nitrogen and phosphorus were studied through a sample survey method. Results revealed that leaf nitrogen content was linearly correlated with leaf phosphorus content along water surface elevation. And water surface elevation significantly affected the nitrogen and phosphorus content of dominant plants. Four dominant species [Cynodon dactylon (Linn.) Pers, Xanthium sibiricum Partin ex Wider, Abutilon theophrasti Medik, and Bidens pilosa Linn] exhibited specific differences in the phosphorus steady state index (Hp) and nitrogen steady state index (HN). Although belonging to different categories, both HP and HN of four dominant species were in the same order: X. sibiricum > A. theophrasti > C. dactylon > B. Pilosa. The interspecific differences in HN and HP indicated that there were differences in the characteristics of nutrient utilization of dominant species and their adaption to water surface elevation. Furthermore, as the elevation increases, the community coverage increased and the community stability index also increased. This might indicate that in the fluctuating zone habitat, the plant’s nitrogen and phosphorus utilization strategy affects the distribution and composition of plant community along water surface elevation, and ultimately affects the stoichiometric homeostasis on the community levels.
Interobserver agreement on definition of the target volume in stereotactic radiotherapy for pancreatic adenocarcinoma using different imaging modalities
Authors: Gkika E. , Kostyszyn D. , Fechter T. , Moustakis C. , Ernst F. , Boda-Heggemann J. , Sarria G. , Dieckmann K. , Dobiasch S. , Duma M. N. , Eberle F. , Kroeger K. , Häussler B. , Izaguirre V. , Jazmati D. , Lautenschläger S. , Lohaus F. , Mantel F. , Menzel J. , Pachmann S. , Pavic M. , Radlanski K. , Riesterer O. , Gerum S. , Röder F. , Willner J. , Barczyk S. , Imhoff D. , Blanck O. , Wittig A. , Guckenberger M. , Grosu Anca-L. , Brunner T. B. 
Published: June 2023

Abstract
Purpose
The aim of this study was to evaluate interobserver agreement (IOA) on target volume definition for pancreatic cancer (PACA) within the Radiosurgery and Stereotactic Radiotherapy Working Group of the German Society of Radiation Oncology (DEGRO) and to identify the influence of imaging modalities on the definition of the target volumes.

Methods
Two cases of locally advanced PACA and one local recurrence were selected from a large SBRT database. Delineation was based on either a planning 4D CT with or without (w/wo) IV contrast, w/wo PET/CT, and w/wo diagnostic MRI. Novel compared to other studies, a combination of four metrics was used to integrate several aspects of target volume segmentation: the Dice coefficient (DSC), the Hausdorff distance (HD), the probabilistic distance (PBD), and the volumetric similarity (VS).

Results
For all three GTVs, the median DSC was 0.75 (range 0.17–0.95), the median HD 15 (range 3.22–67.11) mm, the median PBD 0.33 (range 0.06–4.86), and the median VS was 0.88 (range 0.31–1). For ITVs and PTVs the results were similar. When comparing the imaging modalities for delineation, the best agreement for the GTV was achieved using PET/CT, and for the ITV and PTV using 4D PET/CT, in treatment position with abdominal compression.

Conclusion
Overall, there was good GTV agreement (DSC). Combined metrics appeared to allow a more valid detection of interobserver variation. For SBRT, either 4D PET/CT or 3D PET/CT in treatment position with abdominal compression leads to better agreement and should be considered as a very useful imaging modality for the definition of treatment volumes in pancreatic SBRT. Contouring does not appear to be the weakest link in the treatment planning chain of SBRT for PACA.
Berberine nanostructures attenuate ß-catenin, a key component of epithelial mesenchymal transition in lung adenocarcinoma
Authors: Malyla Vamshikrishna , De Rubis Gabriele , Paudel Keshav Raj , Chellappan Dinesh Kumar , Hansbro Nicole G. , Hansbro Philip M. , Dua Kamal 
Published: June 2023

AbstractLung cancer (LC) is the leading cause of cancer-related deaths globally. It accounts for more than 1.9 million cases each year due to its complex and poorly understood molecular mechanisms that result in unregulated cell proliferation and metastasis. β-Catenin is a developmentally active protein that controls cell proliferation, metastasis, polarity and cell fate during homeostasis and aids in cancer progression via epithelial–mesenchymal transition. Therefore, inhibition of the β-catenin pathway could attenuate the progression of LC. Berberine, an isoquinoline alkaloid which is known for its anti-cancer and anti-inflammatory properties, demonstrates poor solubility and bioavailability. In our study, we have encapsulated berberine into liquid crystalline nanoparticles to improve its physiochemical functions and studied if these nanoparticles target the β-catenin pathway to inhibit the human lung adenocarcinoma cell line (A549) at both gene and protein levels. We observed for the first time that berberine liquid crystalline nanoparticles at 5 µM significantly attenuate the expression of the β-catenin gene and protein. The interaction between berberine and β-catenin was further validated by molecular simulation studies. Targeting β-catenin with berberine nanoparticles represents a promising strategy for the management of lung cancer progression.
Comparison of quantitative FDG-PET and MRI in anti-LGI1 autoimmune encephalitis
Authors: Sadaghiani Mohammad S. , Roman Samantha , Diaz-Arias Luisa A. , Habis Ralph , Venkatesan Arun , Probasco John C. , Solnes Lilja B. 
Published: June 2023

Abstract

Objectives

Anti-leucine glioma-inactivated protein 1 (anti-LGI1) autoimmune encephalitis (AE) presents as subacute memory loss, behavioral changes, and seizures. Diagnosis and treatment delays can result in long term sequelae, including cognitive impairment. 18F-FDG PET/CT may be more sensitive than MRI in patients with AE. Our objective was to determine if anti-LGI1 is associated with a distinct pattern of FDG uptake and whether this pattern persists following treatment.

Methods
Nineteen18F-FDG PET/CT brain scans (13 pre-treatment, 6 convalescent phase) for 13 patients with anti-LGI1 were studied using NeuroQ™ and CortexID™. The sensitivity of the PET images was compared to MRI. The Z scores of 47 brain regions between the pre-treatment and next available follow-up images during convalescence were compared.

Results
All 18F-FDG PET/CT scans demonstrated abnormal FDG uptake, while only 6 (42.9%) pre-treatment brain MRIs were abnormal. The pre-treatment scans demonstrated hypermetabolism in the bilateral medial temporal cortices, basal ganglia, brain stem, and cerebellum and hypometabolism in bilateral medial and mid frontal, cingulate, and parietotemporal cortices. Overall, the brain uptake during convalescence showed improvement of the Z scores towards 0 or normalization of previous hypometabolic activity in medial frontal cortex, inferior frontal cortex, Broca’s region, parietotemporal cortex, and posterior cingulate cortex and previous hypermetabolic activity in medial temporal cortices, caudate, midbrain, pons and cerebellum.

Conclusions
Brain FDG uptake was more commonly abnormal than MRI in the pre-treatment phase of anti-LGI1, and patterns of dysmetabolism differed in the pre-treatment and convalescent phases. These findings may expedite the diagnosis, treatment, and monitoring of anti-LGI1 patients.
Habitat quality affects the social organization in mouse lemurs (Microcebus griseorufus)
Authors: Abel Christoph , Giertz Peggy , Ratovonamana Yedidya R. , Püttker Thomas , Rakotondranary S. Jacques , Scheel Bettina M. , Lenz Tobias L. , Ganzhorn Jörg U. 
Published: June 2023

Abstract
Species can either maintain a certain social organization in different habitats or show different social organizations in similar habitats. The reasons underlying this variability are not always clear but might have consequences for population dynamics, especially under changing environmental conditions. Among mammals, the primate genus Microcebus lives in small groups of closely related females, derived from female philopatry and dispersed males, as illustrated by the well-studied Microcebus murinus. Here, we studied the genetic structure of a population of the congeneric Microcebus griseorufus, inhabiting three adjacent habitats with different resource availabilities. In order to learn more about the plasticity of the species’ social organization under these different conditions, we analyzed the spatial arrangement of mitochondrial haplotypes of 122 individuals. The study revealed high haplotype diversity and a pronounced difference in spatial distribution between the sexes. Females exhibited spatial aggregation of haplotypes, suggesting a system of female philopatry and matrilines, similar to M. murinus. Male haplotypes were dispersed, and males were more likely to carry rare haplotypes, indicating higher dispersal activity. These findings hint towards the unity of the social organization across the genus Microcebus, suggesting a phylogenetic origin of the social organization. Yet, with decreasing resources, the clustering of female haplotypes declined and approached a random distribution in the marginal habitat, with cluster sizes correlating with resource availability as predicted by the socioecological model. Our study supports the notion that social organization is shaped by both phylogenetic origin and ecological conditions, at least in these small primates.

Significance statement
Impacts of habitat degradation are mostly described in terms of changes in population densities in relation to the reduction of resources. This neglects the possible effects of altered social organizations due to declining resources or population densities. Using a genetic sampling of three subpopulations of mouse lemurs in Madagascar along a gradient of food availability up to the limit of the species’ ecological tolerance, we show that their social organization consisting of spatial clusters of closely related females and overdispersed males converges towards random spatial distributions of both sexes with declining food availability.
Lobectomy Versus Sublobar Resection in Simultaneous Bilateral Thoracoscopic Lung Resection
Authors: Liu Yu‐Wei , Wu Ming‐Ho , Kao Chieh‐Ni , Chiang Hung‐Hsing , Lee Jui‐Ying , Li Hsien‐Pin , Chang Po‐Chih , Chou Andre , Chou Shah‐Hwa 
Published: June 2023

AbstractBackgroundSimultaneous bilateral thoracoscopic lung resection (SBTLR) has been shown to be a feasible and efficacious approach for a wide range of pulmonary conditions. Our aim was to evaluate the impact of different procedures on surgical outcomes in patients receiving SBTLR.MethodsBetween 2012 and 2021, 207 patients with bilateral lung neoplasms who underwent SBTLR were retrospectively reviewed. Fifty‐one patients received ipsilateral plus contralateral lobectomy or sublobectomy (lobar group), whilst 156 patients received bilateral sublobectomy (sublobar group). Propensity scores were calculated and matched. Perioperative and clinicopathologic outcomes were compared.ResultsThe lobar group had a greater mean age (64.5 vs. 60.0 years, p = 0.008), longer operative time (254 vs. 205 min, p < 0.001), and more blood loss (74 vs. 46 ml,p < 0.001). The sublobar group had fewer complications (6.4 vs. 19.6%, p = 0.006), shorter hospital stay (4.8 vs. 7.4 days, p < 0.001), and lower hospital costs (p = 0.03). Among 50 pairs of matched groups, significant differences were found only in operative time, hospital stay, and costs. Maximum tumor size and pathological features differed significantly before and after matching (all p < 0.05), with the lobar group consistently demonstrating a larger main tumor (median, 2.5 cm) and a higher percentage of primary lung cancer (84%). Multivariate logistic regression analysis showed that a longer operative time was the factor associated with more complications (OR: 1.01; 95% CI 1.00–1.02, p = 0.002).ConclusionsWith regard to SBTLR, our data suggests that sublobectomy may reduce the prolonged recovery, hospital costs, and complications incurred by lobectomy, without compromising oncological outcomes.
Measurement of the turbulent heat fluxes in mixed convection using combined stereoscopic PIV and PIT
Authors: Mommert Michael , Niehaus Konstantin , Schiepel Daniel , Schmeling Daniel , Wagner Claus 
Published: June 2023

Abstract
The results of simultaneous measurements of velocity and temperature fields in a turbulent mixed convection airflow are analyzed and discussed. To access local temperature and velocity fields in airflows, we present a combination of stereoscopic particle image velocimetry and particle image thermometry. The obtained flow fields make it possible to determine the local convective heat fluxes, thus giving insight into the dynamics of plumes and Taylor–Görtler-like vortices. The evaluated mean local heat fluxes further reveal that the main convection roll transports a substantial amount of heat along the cooling plate and back to the heated bottom plate. Yet, the associated mean turbulent heat fluxes remain positive as they are dominated by the correlation of the temperature and the vertical velocity component. More specifically, a statistical analysis of the local heat flux distribution reveals that Taylor–Görtler-like vortices lead to more skewed distributions of the turbulent convective heat fluxes than plumes.

Graphical abstract
Incidence and associated morbidity of sarcopenia in non-malignant small and large bowel anastomosis: propensity score-matched analysis
Authors: Traeger Luke , Bedrikovetski Sergei , Nguyen Thuy-My , Moore James W. , Sammour Tarik 
Published: June 2023

Abstract
Purpose
Sarcopenia is a prognostic factor for poor outcomes in colorectal cancer, but data are scarce in colorectal surgery for benign conditions where patients could benefit from a deferral of surgery to enter a prehabilitation programme. We assessed the incidence of sarcopenia and complications in patients with benign colorectal disease.

Methods
Patients who underwent elective non-malignant colorectal surgery during 2018–2022 were retrospectively identified. The cross-sectional psoas area was calculated using computed tomography (CT) imaging mid-3rd lumbar vertebrae. Sarcopenia was determined using gender-specific cut-offs. The primary outcome was complications measured by the comprehensive complication index (CCI).

Results
Of 188 patients identified, 39 (20.7%) were sarcopenic. Patients diagnosed with sarcopenia were older (63 vs. 58 years, p = 0.047) and had a reduced BMI (24.7 vs. 27.38 kg/m2, p = 0.001). Sarcopenic patients had more complications (82.1 vs. 64.4%, p = 0.036), and CCI was statistically but not clinically higher (20.9 vs. 20.9, p = 0.047). On univariate linear regression analysis, age ≥ 65 years old, ASA grade ≥ 3, active smokers, sarcopenia, and preoperative anaemia were predictive of CCI. Propensity score-matched analysis was performed, matching 78 cases to remove selection bias, which demonstrated sarcopenia had no impact on postoperative complications. On multivariate analysis, age (p = 0.022), smoking (p = 0.005), and preoperative anaemia (p = 0.008) remained predictive of CCI.

Conclusion
Sarcopenia is prevalent in one-fifth of patients undergoing benign colorectal surgery. Taking advantage of the longer preoperative waiting periods, sarcopenia could be explored as a target for prehabilitation programmes to improve outcomes.
MRI surveillance after translabyrinthine vestibular schwannoma resection and cochlear implantation: is it feasible?
Authors: Dahm Valerie , Schwarz-Nemec Ursula , Arnoldner Michael A. , Liepins Rudolfs , Auinger Alice B. , Matula Christian , Arnoldner Christoph 
Published: June 2023

Abstract
Purpose
Cochlear implantation in patients with vestibular schwannomas is of increasing importance and interest. Two remaining challenges are the assessment of conduction of the cochlear nerve and the possibility of postoperative surveillance with magnetic resonance imaging. The aim of the current study was to assess follow-up imaging and determine the visibility of the internal auditory canal after vestibular schwannoma resection and cochlear implantation as well as in patients with persistent vestibular schwannomas and cochlear implants in place. Visibility of the internal auditory canal, cerebellopontine angle, and labyrinth were evaluated and graded.

Methods
For this retrospective study, 15 MR examinations of 13 patients after translabyrinthine vestibular schwannoma resection and ipsilateral cochlear implantation were included. All patients had been implanted with an MED-EL cochlear implant. Magnetic resonance imaging was carried out on a 1.5T device. All patients were prepped according to the manufacturer’s recommendations.

Results
All 15 examinations were carried out without any adverse event during imaging, such as pain, magnet dislocation, or malfunction. The internal auditory canal and the cerebellopontine angle were sufficiently visible in all cases to allow for vestibular schwannoma follow-up.

Conclusion
Magnetic resonance imaging surveillance of the internal auditory canal following vestibular schwannoma resection and cochlear implantation is feasible and safe with modern implants with a 1.5T magnetic resonance imaging device using metal artifact reduction sequences. Necessary follow-up imaging should not be a contraindication for cochlear implantation in patients with vestibular schwannomas.
Validity and reliability of the Niigata PPPD Questionnaire in a Western population
Authors: Castillejos-Carrasco-Muñoz Rodrigo , Peinado-Rubia Ana Belén , Lérida-Ortega Miguel Ángel , Ibáñez-Vera Alfonso Javier , Tapia-Toca María Cruz , Lomas-Vega Rafael 
Published: June 2023

Abstract
Purpose
To analyze the psychometric properties of the Niigata Questionnaire (NPQ) for use in a European population with persistent postural-perceptual dizziness (PPPD).

Methods
Observational study included 140 patients with different vestibular conditions. Construct validity, internal consistency and concurrent validity were analyzed. Intra-class correlation coefficient (ICC), standard error of measurement (SEM) and minimal detectable change (MDC) were calculated. Receiver operating characteristic (ROC) curve was used to test diagnostic values.

Results
Of the 140 patients, 47 had a diagnosis of PPPD. Factorial analysis showed a single-factor structure and concurrent validity analysis showed strong correlations with other instruments. Cronbach alpha coefficients of 0.938 for the total score, 0.869 for the standing and gait subscale, 0.803 for the subscale of movements and 0.852 for the visual stimulation subscale were obtained. The reproducibility was substantial except for the standing subscale, which could be considered moderate. For the standing, movement and visual stimulation subscales and for the total score, the SEM was 3.27, 2.41, 2.50 and 6.63, respectively, and the MDC was 6.40, 4.72, 4.91 and 12.99, respectively. The NPQ total score showed an area under the curve (AUC) of 0.661, a sensitivity of 72.34 and a specificity of 55.91 for discriminating between PPPD and other vestibular disorders.

Conclusions
The NPQ is feasible for use in a Western population and presents a uni-factorial structure, high internal consistency and strong correlation with other instruments. The reliability can be considered substantial. The NPQ has low accuracy in discriminating between subjects with or without PPPD.