bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sperm immotility is associated with epididymis metabolism disorder in mice under obstructive azoospermia
Authors: Gao Sheng , Chen Zhengru , Shi Jie , Chen Zifeng , Yun Damin , Li Xinyao , Wu Xiaolong , Sun Fei 
Published: July 2023

AbstractObstructive azoospermia (OA) accounts for approximately 40% of males who suffer from azoospermia of male infertility. Currently, available treatment for OA consists of reproductive tract surgical reconstruction and sperm retrieval from the testis. However, both treatments result in low fertility compared to normal pregnancy, and the main reason remains largely unknown. Previous studies have shown that the quality of sperm retrieved from OA patients is poor compared with normal adult males but without an in‐depth study. Herein, we generated a mouse OA model with vasectomy to evaluate sperm quality systematically. Our results showed that the testis had normal spermatogenesis but increased apoptotic activity in both OA patients and mice. More importantly, epididymal morphology was abnormal, with swollen epididymal tubules and vacuole‐like principal cells. Especially, sperm retrieved from the epididymis of OA mice showed poor motility and low fertilization ability in vitro. Using mass spectrometry in epididymal fluid, we found differences in the expression of key proteins for sperm maturation, such as Angiotensinogen (AGT), rhophilin‐associated tail protein 1 (ROPN1), NPC intracellular cholesterol transporter 2 (NPC2), and prominin 1 (PROM1). Furthermore, our results demonstrated that AGT, secreted by epididymal principal cells, could regulate sperm motility by managing PKCα expression to modify sperm phosphorylation. In conclusion, our data evaluate sperm quality systematically in OA mice and contribute to the understanding between the sperm and epididymis, which may provide novel insight into treating male infertility.
Real-World Major Adverse Cardiovascular Events of Nicorandil and Nitrate in Coronary Heart Disease in Central China: A Retrospective Cohort Study
Authors: Li Ping , Chen Juan , Li Na , You Xiang , Shen Lan , Zhou Ning 
Published: July 2023

Objective:
Residual cardiovascular risk in patients with coronary heart disease (CHD) still needs to be addressed in real-world practice. This study aimed to examine the clinical effectiveness of nicorandil and nitrate in addition to optimal treatment for CHD patients.

Methods:
This retrospective cohort study included patients with CHD between October 2009 and March 2020 from 2 tertiary hospitals in Wuhan, China. Patients were grouped into nicorandil and nitrate groups depending on the first recorded antianginal therapy. Demographic and clinical data were collected from databases of the 2 hospitals. The primary outcome was cumulative 18-month major adverse cardiovascular event (MACE)-free survival, which was evaluated by Kaplan-Meier analysis. Propensity score matching (PSM) and multivariate Cox regression were adopted to adjust for confounding factors.

Results:
A total of 14,275 patients were analyzed, including 590 and 13,685 patients in the nicorandil and nitrate groups, respectively. With a median follow-up of 0.88 (Q1, Q3: 0.21, 1.54) years, the cumulative 18-month MACE-free survival rates were comparable between the 2 groups (80.0% vs. 75.0%, adjusted hazard ratio (aHR): 1.04, 95% confidence interval (CI): 0.42–2.56, P = 0.982,7) after 1:4 PSM. The cumulative 18-month stroke-free survival rate was significantly higher in the nicorandil group compared to the nitrate group (93.0% vs. 84.0%, aHR: 0.56, 95% CI: 0.34–0.92, P = 0.023,5).

Conclusion:
This retrospective study showed that nicorandil and nitrate have similar 18-month rates of MACEs in CHD patients, but nicorandil is associated with lower incidence of stroke compared to nitrate. More studies need to be conducted to validate this association and explore the long-term benefit of nicorandil use on the occurrence of MACEs in the future.
Can the Ability to Recognize Facial Emotions in Individuals With Neurodegenerative Disease be Improved? A Systematic Review and Meta-analysis
Authors: Mirzai Naz , Polet Kévin , Morisot Adeline , Hesse Solange , Pesce Alain , Louchart de la Chapelle Sandrine , Iakimova Galina 
Published: July 2023

Background:
Facial emotion recognition (FER) is commonly impaired in individuals with neurodegenerative disease (NDD). This impairment has been linked to an increase in behavioral disorders and caregiver burden.

Objective:
To identify interventions targeting the improvement of FER ability in individuals with NDD and investigate the magnitude of the efficacy of the interventions. We also wanted to explore the duration of the effects of the intervention and their possible impacts on behavioral and psychological symptoms of dementia and caregiver burden.

Method:
We included 15 studies with 604 individuals who had been diagnosed with NDD. The identified interventions were categorized into three types of approach (cognitive, neurostimulation, and pharmacological) as well as a combined approach (neurostimulation with pharmacological).

Results:
The three types of approaches pooled together had a significant large effect size for FER ability improvement (standard mean difference: 1.21, 95% CI = 0.11, 2.31, z = 2.15, P = 0.03). The improvement lasted post intervention, in tandem with a decrease in behavioral disorders and caregiver burden.

Conclusion:
A combination of different approaches for FER ability improvement may be beneficial for individuals with NDD and their caregivers.
Blood clot resolution using active fluid exchange in the treatment of intraventricular hemorrhage
Authors: Haldrup Mette , Jakobsen Anders Mølgaard , Rasmussen Mads , Dyrskog Stig , Simonsen Claus Ziegler , Grønhøj Mads , Poulsen Frantz Rom , Korshøj Anders Rosendal 
Published: July 2023

AbstractObjectiveIntraventricular hemorrhage (IVH) is a severe condition with poor outcome and high mortality. New treatments are warranted to facilitate clot removal and accelerate recovery of IVH patients. We examined the effect to intraventricular lavage on IVH resolution, clearance and kinectics. The study is a post-hoc study on a recently performed randomized study, where intraventricular lavage using controlled irrigation and aspiration was tested against passive drainage. The present study describe post hoc analysis of the Active Study to determine the effect of intraventricular lavage on IVH resolution clearance and kinetics.MethodpostPost-hoc analysis using data from the multi-center, randomized, controlled clinical safety/feasibility trial (Active Study,NCT05204849) including 21 patients with IVH. IVH clearance was assessed using volume segmentation of serial CT scans. Clot resolution kinetics were determined and correlated with irrigation rates.ResultsThe data set consisted of 77 sequential CT scans from 18 patients (3 of the 21 patients included in the Active study were excluded due to rebleeding or only one CT scan performed). Baseline characteristics were equal in the two groups. Clot resolution followed 0-order kinetics. The clot half-life was 3.9 days in the group treated with intraventricular lavage compared to 5.3 days in the control group treated with passive drainage (p = 0.6). We did not observe accelerated clot resolution in the ventricles containing the catheter tip (3.9 days vs 3.6 days, p = 0.9). In the intervention group, clot resolution was increased by 0.05% per ml increase in irrigation (slope 1.576 ml/cm3 (95%CI 0.55-2.6) p=0.03)ConclusionWe found that IVH clot resolution followed 0-order kinetics. No significant differences in clot half-life were observed between the two groups. However, the clot resolution rate was positively correlated with the irrigation rates.
Business climate and sustainability of Cameroonian small and medium enterprises in times of COVID-19
Authors: Djeudja Rovier , Salamon Yang 
Published: July 2023

Purpose The purpose of this study is to evaluate the contribution of the business climate on the sustainability of Cameroonian small- and medium-sized enterprises (SMEs) in times of coronavirus disease 2019 (COVID-19).Design/methodology/approach To achieve this purpose, the study proceed with a quantitative analysis using the simple LOGIT model on a sample of 52 individuals.FindingsThrough the administration of questionnaires and estimations, results reveal that certain variables such as the taxation regime of the enterprise, the different types of taxes paid by the enterprise, the frequency of payment of income tax, the nature of the training of managers, the clauses of the debt contracts with banks/EMFs (Microfinance institution), the time taken to apply for a loan from the bank and the nature of the manager’s training have a negative influence on the sustainability of Cameroonian SMEs during COVID-19, while others such as the evolution of financial profitability in the context of the coronavirus pandemic in Cameroon, the company’s sector of activity and the main methods of financing the SME have a positive influence on the sustainability of Cameroonian SMEs during COVID-19 pandemic. The improvement of the business climate by the institutional authorities is, therefore, essential in the perspective of an eventual development of the country; the said development cannot take place without capitalizing on the potential for income and job creation by SMEs.Research limitations/implicationsThe first limitation is related to the size of the sample and also to the specificity of our study. In fact, the study is conducted among individuals/actors likely to have access to information on the business climate and sustainability of Cameroonian SMEs at the time of COVID-19 encountered in the city of Yaoundé. In this context, the sample size is considered to be small (52). This element does not immediately allow the results of the present research to be generalized to all regions where SMEs are located in Cameroon, as other criteria or other elements must still be taken into account and the results obtained must, therefore, be interpreted with caution. This research could be deepened in the future by considering more business climate variables on the one hand and a larger sample size extended to all cities in Cameroon on the other.Practical implications The results of this research confirm the importance of institutional bodies establishing a rigorous policy of support for businesses. Such a policy would contribute to improving the business climate and extend beyond mere resilience.Originality/value The originality of this study lies in the fact that it looks at the sustainability of SMEs in the context of the COVID-19 pandemic in Cameroon using a simple LOGIT econometric model.
Normal force calculation of two-degree-of-freedom direct drive induction motor considering coupling effect
Authors: Nie Rui , Meng Yaqian , Wang Peixin , Su Peng , Si Jikai 
Published: July 2023

Purpose
The purpose of this study is to calculate the normal force of a two degree of freedom direct drive induction motor considering coupling effects based on an analytical model. Compared with the traditional single degree of freedom motor, normal force characteristics of two-degree-of-freedom direct drive induction motor (2DOFDDIM) is affected by coupling effect when the machine is in a helical motion. To theoretically explain the influence mechanism of coupling effect, this paper conducts a quantitative analysis of the influence of coupling effect on normal force based on the established analytical model of normal force considering coupling effect.

Design/methodology/approach
Firstly, the normal forces generated by 2DOFDDIM in linear motion, rotary motion and helical motion are investigated and compared to prove the effect of the coupling effect on the normal force. During this study, several coupling factors are established to modify the calculation equations of the normal force. Then, based on the multilayer theoretical method and Maxwell stress method, a novel normal force calculation model of 2DOFDDIM is established taking the coupling effect into account, which can easily calculate the normal force of 2DOFDDIM under different motions conditions. Finally, the calculation results are verified by the results of 3D finite element model, which proves the correctness of the established calculating model.

Findings
The coupling effect produced by the helical motion of 2DOFDDIM affects the normal force.

Originality/value
In this paper, the analytical model of the normal force of 2DOFDDIM considering the coupling effect is established, which provides a fast calculation for the design of the motor.
The impact of perceived fairness, organizational and professor support on students' intentions to quit
Authors: Chambers Silvana , Mayfield Clifton O. , Valenti Alix 
Published: July 2023

PurposeThe extant research on student attrition and retention has relied on models that focus on factors over which universities may have limited control and thus not lead to actionable practices. To address this shortcoming, the authors applied organizational support theory (OST) to test the association between students' perceptions of justice, perceived organizational support (POS), perceived professor support, organizational identification, and intention to quit.Design/methodology/approachUsing items from validated scales, a survey was used to collect data from students in the college of business at a southwestern public university in the United States. A final sample of 316 observations was fitted to a structural equation model to test the study's a priori hypotheses.FindingsThe authors found that professor support and procedural justice had direct positive effects on POS. Distributive justice and interactional justice indirectly influenced POS through professor support. In turn, POS had decreased students' intention to quit and increased their organizational identification. The antecedents of POS indirectly influenced intention to quit and organizational identification. The determinants in the model accounted for 12% of the variance in students' intentions to quit, and 25% of students' organizational identification.Originality/valueThis study contributes to the student attrition literature where few studies have applied OST to student populations despite the strong link between POS and intention to quit in employment settings. In this study, the authors provide evidence of the suitability of the OST framework to predict students' intentions to quit.
Determinants of tourism participation of Yoruba traditional and festival of class (Eyo and Ojude-Oba) in southwestern Nigeria
Authors: Agbabiaka Hafeez Idowu , Omisore Olufemi Emmanuel , Olugbamila Omotayo Ben 
Published: July 2023

Purpose
Every community with the potential to organize a festival aims to actualize increased participation to transform the community image and socio-cultural cohesion. Hence, this study aims to investigate the motivational factors influencing festival participation of Eyo and Ojude Oba in southwestern Nigeria, using the push and pull and activity theories as theoretical footing.

Design/methodology/approach
Primary data was collected through questionnaire administration on members of the host communities. Geospatial data was collected on the number of buildings through high-resolution satellite imagery and maps sourced from the Cooperative Information Network (COPINE) of the National Space Research and Development Agency (NASRDA). Systematic sampling procedure was adopted to select 3% of the estimated 5231 and 4,934 buildings within the designated zones in Lagos Island and Ijebu Ode, respectively. In this case, 314 and 148 respondents were sampled in Lagos Island and Ijebu-Ode, respectively. Data collected were analyzed using mean index and factor analysis (principal component analysis).

Findings
This study revealed that the factors influencing participation of Eyo and Ojude Oba festivals comprise six and three factors, respectively, with varying contributions. Eyo festival explained 75.34% variance with varying factors extracted which are psychosocial (22.9%), proximity/mobility (9.93%), facility (13.41%), environmental/cultural (12.2%), demographic (10.65%) and health/safety factors (6.25%). While factors influencing Ojude-Oba festival comprises of sociocultural/psychological (35.44%), facilities/mobility (28.00%) and demographic factor (8.51%), thereby explaining 71.95% variation of factors influencing its participation. The study therefore, prove policy response in enhancing the destination receptors based on the influencing factors to promote positive words of mouth and encourage visitors’ intention to revisit.

Originality/value
This study focused on two distinguished festivals with internal homogenous and external heterogeneous features (Eyo and Ojude-Oba festivals). Ojude-Oba is an annual festival of class, whereas Eyo is non-annual traditional festival. Both festivals are mega, with similarities in the activities engaged in by the visitors and members of the communities, inform of colorful display of costumes, dances, chanting of songs and group parades among other activities.
The effects of Experience-Technology Fit (ETF) on consumption behavior: Extended Reality (XR) visitor experience
Authors: Jung Timothy , Bae Sujin , Moorhouse Natasha , Kwon Ohbyung 
Published: July 2023

PurposeTraditionally, Task–Technology Fit (TTF) theory has been applied to examine the usefulness of technology in the work environment. Can the same approach (based on experience rather than tasks) be applied to non-work, cultural heritage environments? This is the question the authors ask in this study. This study proposes a new variation of TTF based on the experience economy model, namely Experience–Technology Fit (ETF), for the non-work environment, in particular, in the context of cultural heritage, where visitor experience is enhanced by extended reality technology, which combines immersive technologies and artificial intelligence.Design/methodology/approachEmploying a quantitative survey method, the empirical analysis seeks to determine the influence of Mixed Reality (MR) characteristics (interactivity, vividness), Voice User Interface (VUI) characteristics (speech recognition, speech synthesis) and experience economy factors (education, entertainment, esthetic, escape) on satisfaction, revisit intention and actual purchase to propose a new ETF model.FindingsVUI, MR, and experience factors were significantly associated with ETF; when combined with MR-based experience, ETF was significantly associated with satisfaction. This study’s findings further demonstrate the relationship between users' satisfaction when engaging with MR-based experience and revisit intention, while purchase intention was significantly associated with the actual purchase.Originality/valueThe novel contribution of this study is the proposal of the EFT model, a new variation of TTF based on the experience economy model. Overall, this study expands the applications of TTF to an experience-oriented business, thereby broadening the authors’ understanding of technological success with a specific focus on the technology fit of Extended Reality (XR) in the context of cultural heritage.
Research ethics and organizations: the neglected ethics of organizational ethnography
Authors: Kristensen Catharina Juul 
Published: July 2023

PurposeWorking with organizations is central to organizational ethnography. However, while research ethics relating to individual participants is widely discussed, research ethics relating to the organizations has been neglected. The purpose of this article is to address this shortcoming and introduce the concept and domain of “meso-ethics” in research ethics. Meso-ethics pertains to organizations as research participants and thus allows for the explicit inclusion of organizations in ethical considerations and practice. Meso-ethics complements the known domains of micro-ethics and macro-ethics in research ethics.Design/methodology/approachThe concept of meso-ethics takes point of departure in the micro-ethical principles of “respect, and avoiding harm” and adjusts these to apply to organizations. The organizations are first defined as a distinct type of research participants, which differs from individual participants. The organizations are formally organized units that possess resources to assert power and stakeholders with a vested interest in the research. Second, the relationship between researchers and organizations is related to issues of power, allowing for a view of the power relations as flexible and relational. Moreover, this includes a potential vulnerability to harm on both sides.FindingsThe new concept and domain meso-ethics allows for explicit reflections and practice of research ethics in relations to organizations, a central participant in organizational ethnography. There is a discussion that meso-ethics should be combined with micro-ethics and macro-ethics in future practice to allow for comprehensive reflections and practice of research ethics.Originality/valueThe article contributes a new concept and domain of research ethics, meso-ethics, in organizational ethnography and related research to explore and practice research ethics in relation to organizations participating in our research. Meso-ethics complements the known domains of micro-ethics and macro-ethics in research ethics.
Shed old baggage and invest wisely. A bibliometric and thematic analysis of disposition effect and investment
Authors: Mundi Hardeep Singh , Vashisht Shailja 
Published: July 2023

Purpose
This paper aims to review, systematize and integrate existing research on disposition effect and investments. This study conducts bibliometric analysis, including performance analysis and science mapping and thematic analysis of studies on disposition effect.

Design/methodology/approach
This study adopted a thematic and bibliometric analysis of the papers related to the disposition effect. A total of 231 papers published from 1971 to 2021 were retrieved from the Scopus database for the study, and bibliometric analysis and thematic analysis were performed.

Findings
This study’s findings demonstrate that research on the disposition effect is interdisciplinary and influences the research in the domain of both corporate and behavioral finance. This review indicates limited research on cross-country data. This study indicates a strong presence of work on investor psychology and behavioral finance when it comes to the disposition effect. The findings of thematic analysis further highlight that most of the research has focused on prospect theory, trading strategies and a few cognitive and emotional biases.

Practical implications
The findings of this study can be used by investors to minimize their biases and losses. The study also highlights new techniques in machine learning and neurosciences, which can help investment firms better understand their clients’ behavior. Policymakers can use the study’s findings to nudge investors’ behavior, focusing on minimizing the effects of the disposition effect.

Originality/value
This study has performed the quantitative bibliometric and thematic analysis of existing studies on the disposition effect and identified areas of future research on the phenomenon of disposition effect in investments.