bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effectiveness, Safety, and Cost Implications of Outpatient Autologous Hematopoietic Stem Cell Transplant for Multiple Myeloma
Authors: Marini Jessica , Maldonado Andy , Weeda Erin , Neppalli Amarendra , Hashmi Hamza , Edwards Kathy 
Published: June 2023

Background and objective:
Autologous hematopoietic stem cell transplant (aHCT) has become standard care for patients with multiple myeloma (MM). Outpatient aHCT with high-dose melphalan conditioning has reduced costs and length of hospital stay. This study aimed to highlight the effectiveness, safety, and cost implications of outpatient vs inpatient aHCT at a tertiary academic medical center, as well as the utility of growth factor use in these patients.

Patients and methods:
Using an institutional HCT database, a total of 100 patients undergoing aHCT for MM were identified; 50 patients who underwent aHCT in the outpatient setting (chemotherapy and stem cell infusion followed by inpatient admission if needed) were compared with 50 patients in the inpatient setting (chemotherapy and stem cell infusion followed by discharge to outpatient setting). Patients were excluded if the melphalan dose was less than 200 mg/m2. Outcomes assessed through retrospective chart review included time to engraftment, incidence of infection, febrile neutropenia, growth factor use, and total length of inpatient stay through day +100.

Results:
Time to neutrophil and platelet engraftment was shorter in the outpatient group than in the inpatient group (14 vs 16 days and 19 vs 21 days, respectively; P < 0.001). Median length of hospital stay was also shorter in the outpatient group (8.5 vs 15.5 days, respectively; P < 0.001).
Ninety percent of the outpatient group required admission for neutropenic fever, and 60% of these patients received growth factor support starting at a median of 9 days after stem cell infusion, for a median duration of 4 days. Compared to 16 patients who did not receive growth factor support, these patients had a significantly shorter time to neutrophil recovery (13 days with vs 15 days without growth factor, P = 0.02) and no difference in the total length of hospital stay (8 days with vs 10 days without growth factor, P = 0.43).

Conclusion:
For adult patients with MM undergoing aHCT, the outpatient setting is safe and reduces the total length of hospital stay and thus overall transplant costs. Growth factor support for patients with febrile neutropenia may not reduce length of stay for subsequent hospitalizations.
Post-Autologous Hematopoietic Cell Transplant Care in the “Home Sweet Home” Setting: A Treatment Paradigm Shift
Authors: Kharfan-Dabaja Mohamed A. , Roy Vivek , Murthy Hemant , Fischer Deborah , Mohty Razan , Greathouse Ashley , Brown Alethea , Moreno Kathryn , Godsey Emily , Higginbotham Jennifer M. , Bartholomew Ashley , Jackson Alexis , Torres-Guzman Ricardo A. , Forte Antonio J. , Ailawadhi Sikander , Dronca Roxana , Maniaci Michael 
Published: June 2023

Background:
Multiple myeloma (MM) is the second most common hematologic malignancy, with 34,470 estimated new cases in 2022. High-dose therapy followed by autologous hematopoietic cell transplantation (auto-HCT) remains a standard treatment for MM even in the era of novel therapies. This is usually performed in hospital-based settings, either in the inpatient or outpatient units. Advanced Care at Home (ACH) represents a virtual hybrid hospital-at-home program that combines a virtual provider-staffed command center with a vendor-mediated supply chain capable of delivering high-acuity care in the comfort of the patients’ own homes. In our program, we used the existing ACH platform to deliver post-HCT care for recipients of auto-HCT.

Patients and methods:
Four patients (female = 2, 50%) with MM, with a median age of 60 (range, 40–74) years, were admitted to the inpatient Blood and Marrow Transplant (BMT) unit. The conditioning regimen consisted of melphalan 200 mg/m2, administered on day –2. All patients received stem cell infusion (day 0) in the inpatient setting, with a median dose of 3.64 (range, 2.92–8.22) × 106/kg CD34 cells.

Results:
Patients were discharged to their homes after completing the infusion on day 0 or day +1 at the latest. Postinfusion care was provided by the ACH team in coordination with the BMT team. The median time intervals to absolute neutrophil count and platelet engraftment were 12 (range, 11–13) and 11 (range, 9–16) days, respectively. All patients were successfully discharged from the ACH program at a median of day +14 (range, day +14 to day +15).

Conclusions:
Our results highlight the feasibility of delivering post-HCT care for auto-HCT recipients in the home setting and confirm the generalizability of this approach.
Environmental Geochemistry and Heavy Metal Assessment in Soils, Surface and Groundwater from Eastern Niger-Delta, Nigeria using Multivariate Pollution Indices
Authors: Amadi, A.N.  , Olasehinde, P.I.  , Yisa, J.  , Shaibu, I.  , Okoye, N.O.  
Published: June 2023

In recent times, there have been increasing interests regarding heavy metal contaminations in the environments, apparently due to their toxicity and perceived persistency within the aquatic systems. Land and water are precious natural resources on which rely the sustainability of agriculture, industrialization and the civilization of mankind. They have been subjected to severe exploitation and contamination due to anthropogenic activities resulting from industrial effluent, refuse dumps, gas flaring, oil spillage and petroleum refining leading to the release of heavy metals into the environment. The results of the analyses indicate a low pH (3.84 – 7.74) and high concentrations of electrical conductivity (28.00 – 752.00), chloride (12.00 – 721.00) and heavy metals in the decreasing order of: Fe > Ni > Cu > Zn > Mn > Cd > V > Co > Pb > Cr > As > Hg. The heavy metal pollution index revealed that the metal pollution in the soil and water ranged from slightly polluted to very highly polluted. The poor sanitary condition coupled with the high degree environmental abuses in terms of oil spillage, gas flaring and industrial effluent in the area are responsible for the low pH, wide range in the concentration of EC, TDS, Chloride, E.coli, total coliform and heavy metals in the soil and water system in the area. Good sanitation, use of welllined soakaway, treatment of industrial effluent before discharge and putting an end to gas flaring and oil spills are advocated. The use of environmentally friendly techniques such as bioremediation and phytoremediation in remediating the contaminated soil and water in the area is recommended.
Dental Turizm Kapsamında Önde Gelen Ülkelerin Whatclinic ile incelenmesi; Türkiye, Meksika, Macaristan ve Hindistan Örneği
Authors: AYDIN Armağan , ISIK Ceyda 
Published: June 2023

Dental turizm sağlık turizmi içerisinde yer alan döviz kazandırıcı hizmetlerden birisidir. Dünya’da dental turizm hizmetleri ile Türkiye, Macaristan, Meksika ve Hindistan öne çıkan ülkeler arasındadır. Çalışmada nitel araştırma yöntemlerinden gömülü teori tercih edilmiştir. Veri kaynağı olarak whatclinic platformundaki Türkiye, Macaristan, Meksika ve Hindistan özelinde olan yorumlar kullanılmış ve ülkelerin güncel durumu analiz edilmiştir.
Whatclinic’ te bulunan otuz ve üzeri yorum alan 42 klinik incelenerek 2531 yorum pyton programı ile excel dosyası haline getirildikten sonra excel makro ile alt kodlar oluşturularak veriler kategorilere ayrıştırılmıştır. Bu veriler kategorileştirildikten sonra R studio ile grafikleştirilmiştir. Elde edilen bulgulara göre en fazla tercih edilen tedaviler 2 ve üzeri kombine işlemlerden oluşan tedavileri içerirken pedodonti bölümünün ise sadece diaspora turizmi kapsamında tercih edilen bir branş olduğu görünmektedir. Çalışmanın önemli bir katkısı olarak diaspora turizminin dental turizm talebinin oluşmasında ciddi etkisi olduğu çalışmada elde edilen diğer bir bulgudur.
Sonuç olarak bulgular ışığında dental turizm kapsamında yapılan pazar çeşitlendirme faaliyetlerinde branşlara yönelik özelleştirilmiş stratejilerin tercih edilmesinin önemli olabileceği, hedef kitle olarak ise diaspora turistlerinin seçilebileceği düşünülmektedir.
Metodologi Pembacaan Kritis Atas Kajian Orientalis Terhadap Hadis
Authors: Safitri Diah , Marna Syamsul Mawardi , Amin Ahmad Syaifuddin 
Published: June 2023

Studi orientalis terhadap hadits dinilai bias akan kepentingan-kepentingan tertentu, namun perspektif mereka sebagai outsider juga berpotensi objektif karena tidak terikat dengan dogma-dogma yang mengikat insiders. Untuk itu diperlukan pembacaan kritis dalam mengkaji hasil studi orientalis terhadap hadits. Artikel ini mendisuksikan tentang metode pembacaan kritis yang dilakukan oleh M. Muṣṭafa Azami, salah satu sarjana muslim yang konsentrasi di bidang kajian hadits dan orientalisme dalam mengkaji karya para orientalis. Merujuk pada karya Azami, Studies in Early Hadith Literature dan dengan menggunakan metode deskriptif-analitis, peneliti mengkaji letak kritik Azami terhadap para orientalis dan perangkat ilmiah apa saja yang dia gunakan dalam membantah tesis orientalis yang bertentangan dengan pendapatnya. Peneliti menyimpulkan bahwa tujuh ketidaktepatan yang dilakukan orientalis saat mengkaji hadits dalam pembacaan Azami adalah ketidaktepatan dalam menentukan objek yang dikaji, invaliditas data, pemaknaan kata yang menyelisihi sejarah, penggunaan metodologi lama dengan cara yang tidak sesuai, klaim individu yang tidak tepat, analisis dan tesis yang kurang tepat serta distorsi sejarah baik secara sengaja maupun tidak. Untuk membantah tesis yang dinilai tidak tepat, Azami menyusun sebuah konstruk metodologi kritik dengan lima perangkat utama yaitu argumentasi logis, data filologis, intertektualitas, referensi historis dan menggunakan teori hadits klasik.
INTERFERENSI BAHASA BUGIS TERHADAP BAHASA INDONESIA DI BANK BRI KANTOR CABANG BARRU
Authors: Lestari Ayu , Syamsudduha Syamsudduha , Usman Usman 
Published: June 2023

Interferensi bahasa Bugis terhadap Penggunaan bahasa Indonesia di bank BRI kantor cabang Barru. Penelitian ini bertujuan untuk mengetahui bentuk interferensi bahasa Bugis terhadap morfologi bahasa Indonesia yang digunakan dalam komunikasi antara pegawai bank dengan nasabah di Bank Kantor Cabang Barru. Jenis penelitian yang digunakan dalam penelitian ini adalah deskriptif kualitatif. Adapun teknik pengumpulan data dalam penelitian ini dilakukan dengan tiga cara, yaitu observasi, perekaman, dan catatan lapangan. Hasil penelitian menunjukka bahwa terdapat bentuk interferensi yang ditemukan pada percakapan antara nasabah dan Customer Service atau teller di bank BRI kantor cabang Barru berupa afiksasi prefiks, klitiksasi jenis proklitik dan enklitik, terdapat pula reduplikasi (pengulangan) dan komposisi (Pemajemukan). Sehingga dapat disimpulkan bahwa di bank BRI Kantor Cabang Barru terjadi interferensi dalam penggunaan bahasa Indonesia antara nasabah dan pegawai.
Media Belajar Inovatif bagi Siswa SDN 05 Pesanggrahan Jakarta: PKM dengan Konsep Service Learning
Authors: Pramanik Purwanti Dyah , Achmadi Mochamad , Nasution Deivy Z 
Published: June 2023

Pengabdian kepada masyarakat (PKM) dengan konsep service learning bertujuan untuk meningkatkan semangat belajar melalui penggunaan media belajar inovatif bagi siswa Â SDN 05 Pesanggarahan Jakarta Selatan. Narasumber dalam kegiatan PKM adalah tiga orang dosen, dan tujuh mahasiswa Diploma 4 Program Studi Pengelolaan Perhotelan Sekolah Pariwisata Trisakti (tim). Â Kegiatan dilaksanakan pada bulan November â€“ DesemberÂ 2018 di SDN 05. Kegiatan dilakukan dengan memberikan Pelatihan menggunakan media belajar yang menarik dan menyenangkan dengan memilih topik mengenal hewan, nomor, bentuk, dan warna dalam bahasa Inggris. Hasil Kegiatan PKM menunjukkan bahwa kegiatan PKM ini dapat meningkatkan semangat belajar, Â Â bekerja sama, dan bersaing untuk menjadi yang terbaik pada siswa-siswa peserta.Â Selain itu kegiatan PKM ini memberikan isnpirasi kepada pendidik SDN 05 untuk memberikan pembelajaran yang menyenangkan.
KEWASPADAAN DINI PADA LANSIA SEBAGAI UPAYA PENCEGAHAN KOMPLIKASI PENYAKIT KRONIS DI POSYANDU SENJA BAHAGIA PAJANG LAWEYAN SURAKARTA
Authors: Listrikawati Martini 
Published: June 2023

Peningkatan usia harapan hidup ini dapat mengakibatkan terjadinya peningkatan jumlah kesakitan akibat gangguan degeneratif. Indonesia saat ini menghadapi triple burden disease yang menambah permasalahan di masyarakat. Masalah yang timbul bukan hanya seputar mewabahnya penyakit menular baru, menjangkitnya penyakit menular lama dan meningkatnya penyakit tidak menular dari waktu ke waktu, tapi juga masalah yang timbul akibat interaksi di antara ketiganya. Tujuannya adalah dapat mengidentifikasi secara dini komplikasi penyakit pada lansia. Metode: melakukan screening dini Gula Darah, Asam Urat dan Kolesterol; Hasil screning dari 54 lansia GDS dalam batas normal sebanyak 62,96% Kolesterol dalam batas normal sebanyak 53,70% dan asam urat dalam batas normal sebanyak 88,88%. Kesimpulan kegiatan pengabdian masyarakat ini bahwa lansia di posyandu senja bahagia beresiko tinggi terjadi komplikasi penyakit kronis terutama diabetes mellitus dan kolesterol.
Decision-Making by Healthcare Professionals in High-Risk Conditions
Authors: Trofimov Andrii , Miliutina Kateryna , Kolodych Daria , Pustovyi Serhii , Trofimova Daria 
Published: June 2023

The most important reserve for improving the efficiency of any institution or organization is to improve the quality of timely management decisions. The conditions of existence of societies (organizations and individuals) in the modern world are constantly and rapidly changing, that makes special demands on the individual decision maker. In the current situation of the global economic crisis, which is accompanied by changes in resource, environmental, political, legislative, industrial, living conditions, management issues become especially relevant and require improvement of their scientific basis.
In connection with the above, the purpose of the work is to present the features of the development of socio-psychological traits identified in the empirical study, depending on the level of management occupied by the person, to optimize its functioning.
”Ja, jeg kan li’ det land, jeg bor i – trods alle mangler”
Authors: Marstal Henrik 
Published: June 2023

”Despite its deficiencies, I like the country I live in”: The Advent of ”Denmark-Songs” and the Breakaway from National Songs as a Discursive Phenomenon
This article identifies and explores a trend in Danish popular music as well as communal singing which arose during the early 1970’s as an antidote to the long-established national songs and songs about the nation. The trend revealed a rather new way of thematizing national identification matters in which a critical attitude towards the country was explicit, although the songs always reflected a deep devotion as well. In this way, the songs in question established a counter-narrative to the national songs which was apparent from the early 1970’s to the mid-1980’s, but was resumed again in the early 2000’s.
By analyzing three distinct ”Denmark songs” by, respectively, No Name (”Fødelandssang”, 1972), Trille (”Danmark”, 1979) and Gnags (”Danmark”, 1986), the article points to three different ways in which such critical yet loving attitudes could be implemented. It is argued that this counter-narrative, which focused on elements of discontinuity, was a function of a self-conscious and critical folk and rock movement during the 1970’s and 1980’s in which the distancing involved was a result of the breakdown of the ”great” narratives of Denmark as a unified nation, fueled by the heated debate prior to the country’s incorporation into the EU in 1973.
Diagnosis and application of rice diseases based on deep learning
Authors: Li Ke , Li Xiao , Liu Bingkai , Ge Chengxin , Zhang Youhua , Chen Li 
Published: June 2023

Background
Rice disease can significantly reduce yields, so monitoring and identifying the diseases during the growing season is crucial. Some current studies are based on images with simple backgrounds, while realistic scene settings are full of background noise, making this task challenging. Traditional artificial prevention and control methods not only have heavy workload, low efficiency, but are also haphazard, unable to achieve real-time monitoring, which seriously limits the development of modern agriculture. Therefore, using target detection algorithm to identify rice diseases is an important research direction in the agricultural field.

Methods
In this article a total of 7,220 pictures of rice diseases taken in Jinzhai County, Lu’an City, Anhui Province were chosen as the research object, including rice leaf blast, bacterial blight and flax leaf spot. We propose a rice disease identification method based on the improved YOLOV5s, which reduces the computation of the backbone network, reduces the weight file of the model to 3.2MB, which is about 1/4 of the original model, and accelerates the prediction speed by three times.

Results
Compared with other mainstream methods, our method achieves better performance with low computational cost. It solves the problem of slow recognition speed due to the large weight file and calculation amount of model when the model is deployed in mobile terminal.
A Case Control Study on the Determinants of Behavior towards Diarrhea in Children under Five Years Old
Authors: Maisarah  , Vera Dian , Is Jun Musnadi , Anwar Sufyan 
Published: June 2023

Aims: The aim of this study was to determine the relationship between knowledge of diarrhea, hand washing behavior, toilet use behavior and the incidence of diarrhea in children under five years old.
Study Design: A case control study.
Place and Duration of Study: The study was conducted in October 2022 at area of the Johan Pahlawan Community Health Center, Aceh Barat District, Aceh Province-Indonesia.
Methodology: The sample size was 92, with 46 cases and 46 controls. The subjects of the case and control groups are mothers with children under five years old. SPSS version 20 was utilized to conduct statistical analysis on both univariate and bivariate data, with the chi-square test being employed to address the hypothesis.
Results: The results showed that both the case and control groups had more children aged ≤2 years. Mothers in the case group were found to have a higher proportion with poor knowledge level (66.2%), poor hand washing behavior (54.3%), and poor toilet use behavior (67.4%) compared to the mothers in the control group. Statistical tests proved that there was a significant relationship between maternal knowledge (p=0.022), hand washing behavior (p=0.020), and toilet use behavior (p=0.001) with the incidence of diarrhea in children under five years old.
Conclusion: Efforts are needed to improve the knowledge and skills of mothers in preventing and managing diarrhea through education by health professionals.
Emergence of Third Generation Tetracyclines: New Magic Bullets to Tackle Antibiotic Resistance in the Post-antibiotic Era
Authors: Jetty Pranitha , Gaddam Soni , Padi Satyanarayana S. V. 
Published: June 2023

Tetracyclines are broad-spectrum antibiotics effective against a wide variety of microorganisms including bacteria, both Gram-positive and Gram-negative, mycoplasmas, rickettsiae, chlamydiae, and protozoan parasites. Owing to their broad-spectrum antimicrobial activities and inexpensiveness, tetracyclines have been used extensively in both human and animal infections and in animal feed as growth promoters. Owing to this, the global prevalence of antibiotic resistance, particularly of tetracyclines, for Gram-positive methicillin-resistant Staphylococcus aureus (MRSA) and Streptococcus pneumoniae and Gram-negative extended-spectrum β-lactamase-producing Escherichia coli and Klebsiella species is high. Indeed, the acquisition of tetracycline-specific resistance genes, mutations within the ribosomal binding site, and/or chromosomal mutations lead to both class-specific and intrinsic antimicrobial resistance (AMR) mechanisms. As drug resistance increases globally, rendering diseases difficult to manage and eventually to mortality, antibiotics are becoming progressively less effective. Therefore, the discovery and development of novel antibiotics with appropriate indications is of the utmost importance. Among all antibiotics, the tetracyclines have acquired much attention due to the optimization of their chemical structures that paved the way to develop and introduce modern tetracyclines, referred to as third generation, namely tigecycline in the recent past, followed by omadacycline, eravacycline, and sarecycline very recently. Intriguingly, these novel tetracyclines are unique in two ways, first, these are highly effective against pathogens that acquired tetracycline-class resistance, and second, these agents exhibit either narrow or broad spectrum of in vitro activity against Gram-positive, Gram-negative, anaerobic, and atypical pathogens, including many drug-resistant strains lead to approval for limited use and unique indications. These beneficial effects represent a new era in the rational use of newer tetracyclines, the new magic bullets to tackle AMR in the post-antibiotic era. The present review focuses on third-generation tetracyclines emphasizing their safety, efficacy, and therapeutic choices in various clinical conditions of in-patient and out-patient settings.
Diagnosis of Sero-negative Rheumatoid Arthritis Depending on Pathology Associated with Clinical Picture
Authors: Farag Aliaa Mamdouh , Elanwar Noha , Elsergany Mervat , Eldeeb Ali , Kassem Elham 
Published: June 2023

Objectives: This study was done to assess the role of synovial tissue analysis in rheumatoid arthritis (RA) patients.
Methods: All data were recorded at baseline. All patients underwent clinical, radiologic, serologic, and histological assessments before treatment. Patients were divided into anti-citrullinated protein antibody (anti-CCP) positive and anti-CCP-negative and were compared according to different disease aspects. Correlations between clinical, laboratory, imaging, histological, and pathophysiological data were done for all patients.
Results: There were no statistically significant differences in synovial cell infiltrates according to the serology.
Conclusion: Both study groups had similar synovial cell infiltrates.