bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessing the effect of powder characteristics of infant milk on the compressibility of milk powder compression molding
Authors: Liu Shaoli , Jiang Xuefeng , Fu Feifan , Aziz Tariq , Li Guipu , Zhao Juanjuan , Shah Sana , Xiao Gongnian , Gong Jinyan , He Guanghua 
Published: May 2023

AbstractInfant formula is an important food for those infants who are deprived of breast milk. However, infant formula powder is prone to fly apart, moisture absorption, sticky spoon, and inaccurate measurement. Block infant formula can solve these problems well. In this study, the characteristics (including particle structure morphology, moisture content, particle size, etc.) of infant formula powder were investigated on the compressive strength and solubility of block infant formula after compression molding with infant formula powder as the object. The results showed that the compressive strength and solubility of the block infant formula made from milk powder with a moisture content of 4.75%, particle size larger than 80 mesh, and morphology of compact grape structure appendages were the best. Therefore, milk powder with this characteristic is the most suitable for the preparation of block infant formula. This study provides referenceable experimental data and theoretical basis for the preparation and application of block infant formula.
Elevated and atmospheric‐level methane consumption by soil methanotrophs of three grasslands in China
Authors: Wang Yufang , Cai Yuanfeng , Hou Fujiang , Bowatte Saman , Jia Zhongjun 
Published: May 2023

AbstractBackgroundMethane (CH4) oxidation driven by soil aerobic methanotrophs demonstrates the capacity of grassland as a CH4 sink.MethodsIn this study, we compared the oxidation characteristics of atmospheric‐level and elevated concentration (10%) CH4 in a typical grassland (steppe) on the Loess Plateau, an alpine meadow (meadow) on the Qinghai‐Tibet Plateau, and an inland arid‐area artificial grassland (pasture) in northwest China and investigated the communities of active methanotrophs and their contribution to CH4 oxidation using DNA‐based stable‐isotope probing and Illumina Miseq sequencing.ResultsThe results showed that the oxidation of atmospheric CH4 only occurred in steppe and meadow soils where the USCγ group of methanotrophs was numerically dominant in the methanotroph community. Pasture soils, with their very low relative abundance of USCγ, did not show atmospheric CH4 oxidation. However, a DNA‐stable isotope probing experiment with 10% CH4 indicated that conventional CH4 oxidizers (Methylocaldum and Methylocystis) rather than USCγ communities assimilated significant amounts of 13CH4 for growth.ConclusionsThe CH4 oxidation mechanisms in the three experimental grassland soils varied significantly. The USCγ group may be obligate oligotrophic microorganisms or their growth requires specific unknown conditions.
Computation of thermal properties of CMSP shell and tube heat exchanger using different types of helical baffles
Authors: Arunachalam D. , Shukla Anuj Kumar , Dewan Anupam , Salhotra Rahul , Singh Deepak Kumar 
Published: May 2023

AbstractThis paper investigates the flow and thermal properties of a combined multiple shell pass (CMSP)‐shell and tube heat exchanger (STHE) with the provision of unilateral ladder‐type helical baffle (ULHB) and continuous helical baffle (HB) in the outer shell pass of the heat exchanger. Two CMSP‐STHEs with ULHB and HB, respectively, are compared with the traditional STHE having segmental baffles (SG‐STHE) using the computational fluid dynamics method. The computational outcomes are validated with the empirical correlations of the Kern and Esso method. The Reynolds‐averaged Navier–Stokes‐based standard k–ω turbulence model accurately predicts the heat transfer (HT) rate and pressure drop. The computed results of HT rate, pressure drop, and logarithmic mean temperature difference corresponding to various mass flow rates (m) for three STHEs are presented. The results show that the overall HT rate of CMSP (ULHB)‐STHE and the CMSP (HB)‐STHE at the same mass flow rate are nearly 28.3% and 14.8% larger than that of traditional SG‐STHE, respectively. Furthermore, the overall area‐weighted average pressure drop (ΔP) of CMSP (HB)‐STHE is smaller than that of SG‐STHE by 26.5% at the same mass flow rate (m) and for CMSP (ULHB)‐STHE it is larger by 2% than that of traditional STHE. Based on the above results, it is concluded that the CMSP (ULHB)‐STHE is a suitable replacement for the conventional SG‐STHEs.
Can antidepressant use be associated with emotional blunting in a subset of patients with depression? A scoping review of available literature
Authors: Jawad Muhammad Youshay , Fatima Maurish , Hassan Umer , Zaheer Zaofashan , Ayyan Muhammad , Ehsan Muhammad , Khan Muhmmad Huzaifa Ahmed , Qadeer Ahsan , Gull Abdul Rehman , Asif Muhammad Talha , Shad Mujeeb U. 
Published: May 2023

AbstractIntroductionDespite frequent recognition of emotional blunting in the published literature, either as a primary symptom of depression or as an adverse effect of antidepressants, there is no systematic synthesis on this topic to our knowledge. We undertook this scoping review to assess the prevalence, clinical features, implicated causes and management of emotional blunting, outlining the phenomenological and clinical gaps in research.MethodA systematic search was done until March 15, 2022, to include all original studies (i.e., interventional trials, cohort & cross‐sectional studies, case reports, and case series). All reviewed data were delineated to answer pertinent clinical, phenomenological, and management questions related to the phenomenon of emotional blunting.ResultsA total of 25 original studies were included in our scoping review. Emotional blunting was described as a persistent diminution in both positive and negative feelings in depressed patients, who could subjectively differentiate it from their acute symptoms. However, the literature lacked the distinction between emotional blunting as a primary symptom of depression or an adverse effect of antidepressants. Common clinical strategies to manage antidepressant‐induced emotional blunting included dose reduction or switching to a different antidepressant.ConclusionEmotional blunting was a significant patient‐reported concern with antidepressants. Future research should clarify phenomenological and neurobiological constructs underlying emotional blunting to improve diagnostic and management skills.
snoRNAs in hematopoiesis and blood malignancies: A comprehensive review
Authors: Challakkara Mohamed Fahad , Chhabra Ravindresh 
Published: May 2023

AbstractSmall nucleolar RNAs (snoRNAs) are noncoding RNA molecules of highly variable size, usually ranging from 60 to 150 nucleotides. They are classified into H/ACA box snoRNAs, C/D box snoRNAs, and scaRNAs. Their functional profile includes biogenesis of ribosomes, processing of rRNAs, 2′‐O‐methylation and pseudouridylation of RNAs, alternative splicing and processing of mRNAs and the generation of small RNA molecules like miRNA. The snoRNAs have been observed to have an important role in hematopoiesis and malignant hematopoietic conditions including leukemia, lymphoma, and multiple myeloma. Blood malignancies arise in immune system cells or the bone marrow due to chromosome abnormalities. It has been estimated that annually over 1.25 million cases of blood cancer occur worldwide. The snoRNAs often show a differential expression profile in blood malignancies. Recent reports associate the abnormal expression of snoRNAs with the inhibition of apoptosis, uncontrolled cell proliferation, angiogenesis, and metastasis. This implies that targeting snoRNAs could be a potential way to treat hematologic malignancies. In this review, we describe the various functions of snoRNAs, their role in hematopoiesis, and the consequences of their dysregulation in blood malignancies. We also evaluate the potential of the dysregulated snoRNAs as biomarkers and therapeutic targets for blood malignancies.
How parents of children with ataxia‐telangiectasia use dynamic coping to navigate cyclical uncertainty
Authors: Schiller Julia , Towne Meghan C. , Epstein Rachel , Thornton Jennifer Karlin , Suslovitch Victoria 
Published: May 2023

AbstractAtaxia‐telangiectasia (A‐T) is a rare, childhood‐onset, multi‐systemic, progressive condition. Parents of children with rare diseases like A‐T are emotionally, socially, and psychologically impacted by the diagnosis. To examine the parental perspective of having a child with A‐T, and to better understand how parents cope with an A‐T diagnosis, we conducted 10 semistructured interviews. Thematic analysis using a phenomenological approach resulted in five themes: (1) Parental responsibilities change as the result of an A‐T diagnosis, (2) An A‐T diagnosis brings about shifts in identity for all family members, (3) Parental coping changes over time, (4) A‐T parents experience continuous uncertainty and a lack of stability, and (5) A‐T parents receive support from various people, places, and resources. Many parents fostered resilience by adopting a present‐centered and positive mindset about the impacts of the diagnosis. Parents also became A‐T experts and used their knowledge to advocate for their children and help mentor other parents. Responses from parents indicated a need for providers to incorporate parental mental well‐being check‐ins to pediatric rare disease appointments and welcome parents as respected members of their children's care team. Genetic counselors are in a unique position to help coordinate complex care for children with A‐T (and other rare diseases) and provide support to family members using the framework of family‐centered care. This paper offers suggestions for expanding support and learning to cope with a difficult diagnosis for parents of children with rare diseases, specifically A‐T, based on stories from parents of children with A‐T.
Baicalin inhibits influenza A (H1N1)‐induced pyroptosis of lung alveolar epithelial cells via caspase‐3/GSDME pathway
Authors: Wei Zhenqiao , Gao Rui , Sun Zhen , Yang Wen , He Qi , Wang Chenhui , Zhang Jingxiang , Zhang Xiaochang , Guo Liang , Wang Shengqi 
Published: May 2023

AbstractBaicalin (7‐d‐glucuronic acid‐5, 6‐dihydroxyflavone) derived from the root of Scutellaria baicalensis used as Traditional Chinese Medicine (TCM) has been revealed to exert potential antiviral activity via various pathways, while the molecular mechanisms have not been fully understood. Pyroptosis, an inflammatory form of programmed cell death (PCD), is reported to play a crucial role in host cell fate during viral infection. In this study, transcriptome analysis of mice lung tissue reveals that baicalin reverses the alterations of the mRNA levels of PCD‐associated genes upon H1N1 challenge, with a concomitant decrease in the population of H1N1‐induced propidium iodide (PI)+ and Annexin Ⅴ+ cells. Intriguingly, we find that baicalin contributes to the survival of infected lung alveolar epithelial cells partly through its inhibition of H1N1‐induced cell pyroptosis, which is manifested by reduced bubble‐like protrusion cells and lactate dehydrogenase (LDH) release. Moreover, the antipyroptosis effect of baicalin in response to H1N1 infection is found to be mediated by its repression on caspase‐3/Gasdermin E (GSDME) pathway. Cleaved caspase‐3 and N‐terminal fragment of GSDME (GSDME‐N) are detected in H1N1‐infected cell lines and mice lung tissues, which are markedly reversed by baicalin treatment. Furthermore, inhibition of caspase‐3/GSDME pathway by caspase‐3 inhibitor or siRNA exerts an antipyroptosis effect equal to that of baicalin treatment in infected A549 and BEAS‐2B cells, indicating a pivotal role of caspase‐3 in the antiviral activities of baicalin. Conclusively, for the first time, we demonstrate that baicalin could effectively suppress H1N1‐induced pyroptosis of lung alveolar epithelial cells via caspase‐3/GSDME pathway both in vitro and in vivo.
Compliance of good storage practices of pharmacies and medicine outlets: a scoping review
Authors: Ching Carly , Fuzail Mohammad Ahsan , Zaman Muhammad H. , Wirtz Veronika J. 
Published: May 2023

AbstractEnsuring good storage practices (GSPs) of medicine outlets is important to maintain and ensure the safety, quality, and efficacy of dispensed medicines. The objective of this scoping review was to determine the most common GSP compliance issues within pharmacies and medicine outlets. PRISMA extension for scoping reviews guidelines were followed, and PubMed and Google Scholar were searched to identify the relevant primary literature from January 2016 and February 2022. All study designs in English were eligible for inclusion as long as they reported quantitative data for the fulfilment of individual GSP activities. Duplicate independent screening of the search results was undertaken. Quality assessment was performed on studies for final inclusion. Data extraction was performed by one reviewer, and the observed aggregate percentage compliance (% compliance), along with 95% confidence interval for the root GSP operation, was calculated. Of the 380 records identified, 15 articles were included. The studies were conducted in 10 countries and the majority were participatory research studies. Fire safety had the lowest aggregate % compliance (0.9%). Controlled substance, climate, light, ventilation and temperature and stock and bookkeeping operations all had overall aggregate % compliance levels below 50%. Despite evidence of basic controls and measures, we identified low compliance for many GSP operations. To ensure the integrity of medicines, it is important to increase the enforcement of security measures, invest resources in personnel training, account for informal vendor practices, and facilitate sharing global data publicly from external and governing body inspections and reviews of storage practices.
Conformational and functional changes from deamidation of wheat gluten with electrochemical treatment
Authors: Dai Yajie , Zhong Wen , Hu Xiaohuan , Ji Xiaorui , Sun Qiuyue , Wang Ruohua , Yu Dianyu , Wu Fei , Wang Liqi 
Published: May 2023

AbstractBackgroundIn this paper, wheat gluten (WG) was modified by electrochemical deamidation. The effects of electrochemical treatment time on the conformation and functional properties of WG and its mechanism were studied.ResultsWheat gluten demonstrated a maximum deamidation of 50.94%. Fourier transform infrared spectroscopy (FTIR) showed a decrease in α‐helix and β‐sheets and an increase in β‐turns and random coils, indicating that the secondary structure of WG became looser and more disordered with increased molecular flexibility. Electrochemical deamidation significantly increased the net charge and solubility of WG, the emulsifying activity index (EAI) increased from 8.53 to 15.66 m2 g−1, the foaming capacity (FC) increased from 4.55 to 13.72 cm3, and the water‐holding capacity (WHC) and oil‐holding capacity (OHC) reached maximum levels of 8.42 g g−1 and 7.45 g g−1, respectively, at 90 min.ConclusionElectrochemical deamidation appears to be a useful technique to improve the processing characteristics of WG. © 2023 Society of Chemical Industry.
Theoretical kinetics analysis of the OH + CH3OH hydrogen abstraction reaction using a full‐dimensional potential energy surface
Authors: Espinosa‐Garcia Joaquín , Garcia‐Chamorro Moisés 
Published: May 2023

AbstractBased on an analytical full‐dimensional potential energy surface (PES), named PES‐2022, fitted to high‐level ab initio calculations previously developed by our group and specifically developed to describe this polyatomic reactive process, an exhaustive kinetics analysis was performed in the temperature range 50–2000 K, that is, interstellar, atmospheric and combustion conditions. Using the competitive canonical unified theory with multidimensional tunneling corrections of small curvature, CCUS/SCT, and low‐ and high‐pressure limit (LPL and HPL) models, in this wide temperature range we found that the overall rate constants increase with temperature at T > 300 K and T < 200 K, showing a V‐shaped temperature dependence, reproducing the experimental evidence when the HPL model was used. The increase of the rate constant with temperature at low temperatures was due to the strong contribution of the tunneling factor. The title reaction evolves by two paths, H2O + CH2OH (R1) and H2O + CH3O (R2), and the branching ratio analysis showed that the R2 path was dominant at T < 200 K while the R1 path dominated at T > 300 K, with a turnover temperature of ∼260 K, in agreement with previous theoretical estimations. Three kinetics isotope effects (KIEs), 13CH3OH, CH318OH, and CD3OH, were theoretically studied, reproducing the experimental evidence. The kinetics analysis in the present paper together with the dynamics study previously reported showed the capacity of the PES‐2022 to understand this important chemical process.
The effect of temperature and predation on performance in monoculture and in competition in three Daphniidae differing in body size
Authors: Bomfim Francieli Fátima , Vanvelk Héléne , Pinheiro‐Silva Lorena , Brans Kristien I. , Lansac‐Tôha Fábio Amodêo , De Meester Luc 
Published: May 2023

AbstractZooplankton body size shows a strong association with temperature, competition, and predation. Global warming affects all three drivers of body size and is thus expected to lead to substantial changes in zooplankton community composition and body size distributions. To disentangle the isolated and joint effect of temperature, competition, and fish predation on species biomass and community composition in zooplankton, we monitored population biomasses of three Daphniidae species that differ in body size (Daphnia magna, Daphnia pulex, and Ceriodaphnia reticulata) for 20 days, manipulating competition (monoculture, pairwise trials, and three‐species communities), temperature (20°C, 24°C, and 28°C) and presence or absence of fish predation. In the absence of predation, D. magna dominated in all competition experiments, even at high temperatures. D. magna went extinct, however, in the predation treatments at 24°C and 28°C. D. pulex outcompeted C. reticulata and was negatively affected by predation and high temperature. C. reticulata did not reduce biomass at high temperatures and was negatively affected by all competition trials, but was positively affected by predation. Our results indicate that the two larger‐bodied species are more negatively affected by the combination of temperature and predation than the smallest species. While higher temperatures reduced the biomass of the larger‐bodied species, it did not fundamentally change their ability to dominate over the smallest species in competition. The combined effect of warming and predation changed community composition more fundamentally, resulting in the dominance of small‐bodied species. This can have important ecosystem‐wide impacts, such as the transition to turbid, algae‐dominated systems.
Exposure to extremes in multiple global change drivers: Characterizing pH, dissolved oxygen, and temperature variability in a dynamic, upwelling dominated ecosystem
Authors: Kroeker Kristy J. , Donham Emily M. , Vylet Kate , Warren Joseph K. , Cheresh Julia , Fiechter Jerome , Freiwald Jan , Takeshita Yuichiro 
Published: May 2023

ABSTRACTIn upwelling systems, fluctuations in seawater pH, dissolved oxygen (DO), and temperature can expose species to extremes that differ greatly from the mean conditions. Understanding the nature of this exposure to extremes, including how exposure to low pH, low DO concentrations, and temperature varies spatiotemporally and in the context of other drivers, is critical for informing global change biology. Here, we use a 4‐yr time series of coupled pH, DO, and temperature observations at six nearshore kelp forest sites spanning the coast of California to characterize the variability and covariance among these drivers. We further compare observed properties to those derived from a high‐resolution coupled physical‐biogeochemical simulation for the central California current system. We find the intensity, duration, and severity of exposure to extreme conditions beyond heuristic, biologically relevant pHT (< 7.7), and DO (< 4.6 mg L−1) values were greatest at sites with strong upwelling. In contrast, sites with relatively weaker upwelling had little exposure to pH or DO conditions below these heuristic values but had higher and more variable temperature. The covariance between pH, DO, and temperature was highest in sites with strong upwelling and weakest in sites with limited upwelling. These relationships among pH, DO, and temperature at the observation locations were mirrored in the model, and model output highlighted geographic differences in exposure regimes across the California marine protected area network. Together, these results provide important insight into the conditions marine ecosystems are exposed to relevant to studies of global change biology.
High Heat Resistance Can Be Deceiving: Dripping Behavior of Polyamide 4.6 in Fire
Authors: Turski Silva Diniz Analice , Marti Julio Marcelo , Schartel Bernhard 
Published: May 2023

AbstractPolyamide 4.6 (PA46) is a high‐heat‐resistant polymer, but it has no dripping resistance under fire. Three commercial grades of PA46 are investigated under UL 94 vertical fire test conditions. Their performances are discussed based on the materials' structural, thermal, and rheological properties. PA46 presents flaming drops, whereas dripping is prevented in the flame‐retarded PA46. Friction‐modified PA46 has increased flaming dripping. Temperature profiles of the specimens under fire and the temperature of the drops are measured by thermocouples. A UL 94 vertical test configuration consisting of two flame applications is designed to assess the quantitative dripping behavior of the set of materials by the particle finite element method (PFEM). Polymer properties (activation energy and Arrhenius coefficient of decomposition, char yield, density, effective heat of combustion, heat of decomposition, specific heat capacity, and thermal conductivity) in addition to rheological responses in high temperatures are estimated and measured as input parameters for the simulations. The dripping behavior obtained by simulated materials corresponds with the experimental results in terms of time and drop size. A consistent picture of the interplay of the different phenomena controlling dripping under fire appears to deliver a better understanding of the role of different materials’ properties.
Advances of antitumor drug discovery in traditional Chinese medicine and natural active products by using multi‐active components combination
Authors: Zhao Wei , Zheng Xiao‐Di , Tang Paula Yun‐Zhi , Li Hong‐Mei , Liu Xue , Zhong Jian‐Jiang , Tang Ya‐Jie 
Published: May 2023

AbstractThe antitumor efficacy of Chinese herbal medicines has been widely recognized. Leading compounds such as sterols, glycosides, flavonoids, alkaloids, terpenoids, phenylpropanoids, and polyketides constitute their complex active components. The antitumor monomers derived from Chinese medicine possess an attractive anticancer activity. However, their use was limited by low bioavailability, significant toxicity, and side effects, hindering their clinical applications. Recently, new chemical entities have been designed and synthesized by combining natural drugs with other small drug molecules or active moieties to improve the antitumor activity and selectivity, and reduce side effects. Such a novel conjugated drug that can interact with several vital biological targets in cells may have a more significant or synergistic anticancer activity than a single‐molecule drug. In addition, antitumor conjugates could be obtained by combining pharmacophores containing two or more known drugs or leading compounds. Based on these studies, the new drug research and development could be greatly shortened. This study reviews the research progress of conjugates with antitumor activity based on Chinese herbal medicine. It is expected to serve as a valuable reference to antitumor drug research and clinical application of traditional Chinese medicine.