bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical epidemiology and disease burden of adenoviral encephalitis in hospitalized children in China: A nationwide cross‐sectional study
Authors: Tian Jiao , Wang Xinyu , Zhang Linlin , Li Qi , Feng Guoshuang , Zeng Yueping , Wang Ran , Xie Zhengde 
Published: August 2023

ABSTRACTImportanceAdenovirus encephalitis is a significant infectious disease of the central nervous system that commonly affects children under the age of 5 and has a profound impact on the health of infants and young children throughout China. National multicenter epidemiological studies have significant public health implications.ObjectiveThis study aims to report the epidemiology of adenovirus encephalitis in hospitalized children in China, providing valuable guidance for clinicians.MethodsThe data utilized in this study were extracted from the comprehensive Futang Update Medical Records database, which comprises discharge medical records collected by 27 tertiary children's hospitals between January 2016 and December 2018 in China. Specifically, the face sheet of discharge medical records encompassed critical sociodemographic variables and basic medical care details.ResultsIn this database, a total of 544 children were hospitalized due to adenoviral encephalitis. The male‐to‐female ratio was 1.62:1, with more boys being affected across different age groups and places of residence. Of the children hospitalized, the highest number of hospitalizations occurred in the 1–3‐year age group and the number of hospitalizations decreased each year from 2016 to 2018. The disease exhibits seasonal characteristics with a pronounced peak in the summer months of June and July. While most children (58%) did not have any significant complications, one‐third of them developed respiratory complications, including pneumonia and acute bronchitis. The median length of stay for adenoviral encephalitis was 7 days, and the median cost of hospitalization was 2145.56 US dollars.InterpretationThis study highlights the prevalence of adenovirus encephalitis in hospitalized children in China. Children aged 1–3 years were found to be the main demographic hospitalized due to this condition, with boys being significantly more affected than girls. The seasonal variations of adenovirus encephalitis were also found to be significant. Fortunately, the fatality rate associated with this condition was low, and the prognosis was generally favorable.
Site‐specific relaxation of peptide bond planarity induced by electrically attracted proton/deuteron observed by neutron crystallography
Authors: Chiba Kaori , Matsui Takuro , Chatake Toshiyuki , Ohhara Takashi , Tanaka Ichiro , Yutani Katsuhide , Niimura Nobuo 
Published: August 2023

AbstractIn structural biology, peptide bonds, fundamental linkages between hundreds of amino acids, of which a protein molecule is composed, have been commonly treated as a plane structure just as Linus Pauling et al. proposed. In this paper, a site‐specific peptide bond relaxation mechanism by deuterons whose localization has been suggested by neutron crystallography is proposed. Such deuteron was observed as an arm of neutron scattering length density protruding from the carbonyl oxygen atoms in the main chain in the omit map drawn by neutron crystallography of human lysozyme. Our comprehensive study using x‐ray and neutron diffraction and 15N chemical shifts of individual amide nitrogen atoms within the same peptide bond strongly suggests the relaxation of the electronic resonance structure because of site‐specific modulation by protons/deuterons localized on the electron orbital of the carbonyl oxygen. All experimental data used in this examination were obtained at room temperature, which is preferable for enzymatic activity. Such a close interaction between the electron resonance structure of a peptide bond and the exchangeable protons/deuterons well agreed with that observed in an intermediate state in an amide hydrolytic reaction simulated by the ab‐initio calculation including water molecules.
Is prostatic adenocarcinoma with cribriform architecture more difficult to detect on prostate MRI?
Authors: Belue Mason J. , Blake Zoë , Yilmaz Enis C. , Lin Yue , Harmon Stephanie A. , Nemirovsky Daniel R. , Enders Jacob J. , Kenigsberg Alexander P. , Mendhiratta Neil , Rothberg Michael , Toubaji Antoun , Merino Maria J. , Gurram Sandeep , Wood Bradford J. , Choyke Peter L. , Turkbey Baris , Pinto Peter A. 
Published: August 2023

AbstractBackgroundCribriform (CBFM) pattern on prostate biopsy has been implicated as a predictor for high‐risk features, potentially leading to adverse outcomes after definitive treatment. This study aims to investigate whether the CBFM pattern containing prostate cancers (PCa) were associated with false negative magnetic resonance imaging (MRI) and determine the association between MRI and histopathological disease burden.MethodsPatients who underwent multiparametric magnetic resonance imaging (mpMRI), combined 12‐core transrectal ultrasound (TRUS) guided systematic (SB) and MRI/US fusion‐guided biopsy were retrospectively queried for the presence of CBFM pattern at biopsy. Biopsy cores and lesions were categorized as follows: C0 = benign, C1 = PCa with no CBFM pattern, C2 = PCa with CBFM pattern. Correlation between cancer core length (CCL) and measured MRI lesion dimension were assessed using a modified Pearson correlation test for clustered data. Differences between the biopsy core groups were assessed with the Wilcoxon‐signed rank test with clustering.ResultsBetween 2015 and 2022, a total of 131 consecutive patients with CBFM pattern on prostate biopsy and pre‐biopsy mpMRI were included. Clinical feature analysis included 1572 systematic biopsy cores (1149 C0, 272 C1, 151 C2) and 736 MRI‐targeted biopsy cores (253 C0, 272 C1, 211 C2). Of the 131 patients with confirmed CBFM pathology, targeted biopsy (TBx) alone identified CBFM in 76.3% (100/131) of patients and detected PCa in 97.7% (128/131) patients. SBx biopsy alone detected CBFM in 61.1% (80/131) of patients and PCa in 90.8% (119/131) patients. TBx and SBx had equivalent detection in patients with smaller prostates (p = 0.045). For both PCa lesion groups there was a positive and significant correlation between maximum MRI lesion dimension and CCL (C1 lesions: p < 0.01, C2 lesions: p < 0.001). There was a significant difference in CCL between C1 and C2 lesions for T2 scores of 3 and 5 (p ≤ 0.01, p ≤ 0.01, respectively) and PI‐RADS 5 lesions (p ≤ 0.01), with C2 lesions having larger CCL, despite no significant difference in MRI lesion dimension.ConclusionsThe extent of disease for CBFM‐containing tumors is difficult to capture on mpMRI. When comparing MRI lesions of similar dimensions and PIRADS scores, CBFM‐containing tumors appear to have larger cancer yield on biopsy. Proper staging and planning of therapeutic interventions is reliant on accurate mpMRI estimation. Special considerations should be taken for patients with CBFM pattern on prostate biopsy.
Assessing the potential of biopesticides to control the cabbage stem flea beetle Psylliodes chrysocephala
Authors: Price Claire Stéphanie Véronique , Campbell Heather , Pope Tom William 
Published: August 2023

AbstractBACKGROUNDCabbage stem flea beetle (CSFB) is an economically important pest of oilseed rape crops in Europe that was effectively controlled by neonicotinoid insecticide seed treatments until they were banned by the European Union in 2013. Since then, CSFB has been a difficult pest to control effectively, in part due to many populations having developed resistance to pyrethroids, the only authorized insecticides used to control this pest in many countries. Alternative solutions are therefore necessary, such as biopesticides. We tested an entomopathogenic fungus, three entomopathogenic bacteria isolates, two fatty acids and azadirachtin against CSFB adults under laboratory conditions. We also tested the efficacy of the pyrethroid insecticide lambda‐cyhalothrin.RESULTSFatty acids were effective, with up to 100% CSFB mortality after 24 h. The entomopathogenic fungus Beauveria bassiana resulted in up to 56% mortality 14 days after treatment. Entomopathogenic bacteria formulations and azadirachtin were not effective (<50% and <40% mortality, respectively). Results from a bioassay using lambda‐cyhalothrin indicated that the CSFB used in this study were resistant to this insecticide.CONCLUSIONEntomopathogenic fungi and fatty acids could potentially be used to control CSFB as part of an integrated pest management programme. This study is the first to investigate the efficacy of different biopesticides to control CSFB under laboratory conditions. As such, these biopesticides require further testing to optimise the formulation and application methods, and to assess the impact on nontarget organisms. Finally, efficacy under field conditions must be determined to understand the influence of environmental variables. © 2023 The Authors. Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
Targeting the programmed cell death (PCD) signaling mechanism with natural substances for the treatment of diabetic cardiomyopathy (DCM)
Authors: Xuan Xiaoyu , Zhang Shiliang 
Published: August 2023

AbstractDiabetic cardiomyopathy (DCM) is one of the severe complications of diabetes, characterized by structural and functional abnormalities in the hearts of diabetic patients without hypertension, coronary heart disease, or valvular heart disease. DCM can progress to heart failure, which is a significant cause of death in diabetic patients, but currently, there is no effective treatment available. Programmed cell death (PCD) is a genetically regulated form of cell death that includes apoptosis, autophagy, necroptosis, ferroptosis, and pyroptosis. PCD is essential for tissue homeostasis and normal development of the body. DCM is a complex condition, and abnormalities in the cascade of PCD signaling have been observed in its pathological process, suggesting that targeting PCD could be a potential therapeutic strategy. Studies have shown that natural substances can effectively modulate PCD to intervene in the treatment of DCM, and their use is safe. This review explores the role of different forms of PCD in the pathogenesis of DCM and summarizes the research progress in targeting PCD with natural substances to treat DCM. It can serve as a basis for further research and drug development to provide new treatment strategies for DCM patients.
An Economical and Eco‐Efficient Ammonium Chloride Promoted Friedländer Condensation: A Study of Microwave‐Assisted Versus Conventional Heating.
Authors: Chaudhary Gyanendra , Brijesh  , Lal Kanhaya , Dhwaz Amar , Prabhakar Amit , Verma Deepti 
Published: August 2023

AbstractA new approach to Friedländer hetero‐annulations reaction is presented here for the synthesis of polysubstituted quinolines and polycyclic quinolines by the use of an inexpensive, nontoxic and readily available NH4Cl promoter. As a promoter, it shows good compatibility with various substrates, its easy removal, no side product, enhances the atom economy and makes the reaction eco‐friendly. Both microwave irradiation and conventional heating accomplished the reaction. The present method provides a comparative study of microwave irradiation versus conventional heating.
How the interplay of late retirement, health care, economic insecurity, and electronic social contact affects the mental health amongst older workers?
Authors: Yuan Bocong 
Published: August 2023

AbstractThe delayed retirement initiative has become increasingly emphasised to cope with the population ageing. Based on the social‐ecological model, this study explores the interplay of late retirement, health care, economic insecurity, and electronic social contact on mental health of older workers. Using data from the Survey of Health, Ageing and Retirement in Europe (wave 8), results show that the late retirement, health care quality, and electronic social contact are all negatively associated with the mental health problems among older workers. Besides, the influence of health care quality and electronic social contact on mental health problems are buffered by the economic insecurity respectively. It is concluded that more targeted policy response is in need to achieve better health outcomes among older workers.
Impact of Treatment with Superheated Steam on the Structural, Thermal, and Functional Characteristics of Quinoa Starch
Authors: Almeida Raphael Lucas Jacinto , Santos Newton Carlos , Ferreira Iêda Letícia de Souza , Pedro Marcelo da Silva , Morais Jessica Renaly Fernandes , de Oliveira Adolfo Pinheiro , Ribeiro Victor Herbert de Alcântara , Silva Virgínia Mirtes de Alcântara , de Lima Thalis Leandro Bezerra , de Moraes Maria Suiane , Silva Semirames do Nascimento , Freire Vitória de Andrade , Galdino Pablícia Oliveira , Silva Rebeca de Almeida 
Published: August 2023

AbstractThe objective of the study is to evaluate the impact of treatment with superheated steam on the structural, thermal, and functional characteristics of quinoa starch. The superheated steam treatment is applied to the starch at 130 and 170 °C for 1 and 4 min, then dried at 50 °C and stored. Moisture adsorption isotherms are performed at 25 °C, and data are fitted to the Oswin, GAB, and Peleg models. Structural characterization is done using XRD and FTIR, thermal analysis using DSC, and functional characterization include water absorption capacity (WAC), oil absorption capacity (OAC), and syneresis. The QS170/4 treatment shows a reduction in crystallinity index of up to 48.24%, with the appearance of the amylose‐lipid complex, an increase in initial and final gelatinization temperatures, and a decrease in enthalpy of up to 39.53%. For modified starches, WAC and OAC increase by 9% and 7%, respectively, and syneresis decreases significantly by 17.4%. The results demonstrate the feasibility of modifying quinoa starch with superheated steam treatment, which, unlike other methods, has the advantage of altering the amylose and amylopectin chains in just a few minutes. Thus, the results show a new perspective for the use of superheated steam in starch modification.
[(K,Rb)@([2.2.2]crypt)]2(K,Rb)4[Si9W(CO)4] ⋅ 13.4 NH3 – The First Tungsten Functionalized Silicon Zintl Cluster
Authors: Braun Paul A. , Westermair Franz F. , Gschwind Ruth M. , Korber Nikolaus 
Published: August 2023

AbstractThe reaction between the heteroleptic metal carbonyl complex [W(CO)4(tmeda)] ((tmeda)=N,N,N′,N′‐Tetramethylethane‐1,2‐diamine) with [Si9]4− silicon Zintl clusters in presence of [2.2.2]crypt ([2.2.2]crypt=4,7,13,16,21,24‐Hexaoxa‐1,10‐diazabicyclo[8.8.8]‐hexacosane) in liquid ammonia yielded the compound [(K,Rb)@([2.2.2]crypt)]2(K,Rb)4[Si9W(CO)4] ⋅ 13.4 NH3. The compound was analyzed by single crystal X‐ray diffraction and crystallizes in the space group
(a=11.48390(10) Å, b=19.7383(2) Å, c=19.8983(2) Å, α=112.5760(10)°, β=97.4210(10)°, γ=95.3760(10)°, V=4079.01(7) Å3). The compound represents the first group 6 carbonylate‐functionalized silicon Zintl cluster. The central moiety is composed of a tricapped trigonal prismatic nine‐atom silicon species which coordinates with the lone pair of one capping atom to the tungsten tetracarbonylate, forming a pseudo trigonal bipyramidal carbonylate cluster anion [Si9W(CO)4]6−. The chemical bonding in the new cluster entity is analyzed using theoretical calculations and subsequent analysis using QTAIM and NBO.
FPGA-Based Network-Attached Accelerators – An Environmental Life Cycle Perspective
Authors: Steinert Fritjof , Stabernack Benno 
Published: August 2023

AbstractHomogeneous computing systems are reaching their limits with the growing demands of current applications. Accelerating compute-intensive applications ensures manageable computing times and boosts energy efficiency, which is an important lever as part of ongoing efforts to tackle global climate change. Field Programmable Gate Array (FPGA) accelerators are well-known for increasing throughput and, in particular, energy efficiency for many applications. FPGA accelerators connected directly to the data center high-speed network are ideal for integration into a heterogeneous data center, avoiding the energy and resource overhead of a carrier system. The standalone Network-attached Accelerators (NAAs) further benefits from low latency and predictable line-rate network throughput, as well as an interoperable communications interface. For selected use cases, we compare a heterogeneous computing cluster extended by NAAs with a homogeneous CPU-based cluster not only in terms of computing performance and energy efficiency, but also considering resource efficiency. For this purpose, we perform a Life Cycle Assessment (LCA) for both systems based on the Key Performance Indicators for Data Center Efficiency (KPI4DCE) indicator set, which takes into account the manufacturing phase in addition to the usage phase. The KPI4DCE tool has been extended to include modeling of NAAs. This allows us to show that NAAs are not only more energy-efficient, but also more resource-efficient for the selected applications, leading to a strong improvement of the environmental impact of the manufacturing phase.
Bernhard Riemann 1861 revisited: existence of flat coordinates for an arbitrary bilinear form
Authors: Bandyopadhyay S. , Dacorogna B. , Matveev V. S. , Troyanov M. 
Published: August 2023

AbstractWe generalize the celebrated results of Bernhard Riemann and Gaston Darboux: we give necessary and sufficient conditions for a bilinear form to be flat. More precisely, we give explicit necessary and sufficient conditions for a tensor field of type (0, 2) which is not necessary symmetric or skew-symmetric, and is possibly degenerate, to have constant entries in a local coordinate system.
Age, growth, and population structure of the African cuttlefish Sepia bertheloti based on beak microstructure
Authors: Guerra-Marrero Airam , Bartolomé Aurora , Couce-Montero Lorena , Espino-Ruano Ana , Jiménez-Alvarado David , Castro José J. , Perales-Raya Catalina 
Published: August 2023

AbstractIn this study, we explored the feasibility of using the beaks of the African cuttlefish Sepia bertheloti for age estimation and growth analysis. The rostrum sagittal section (RSS) of the lower beak was the most suitable region in the species. It was applied in samples caught off Morocco and Guinea-Bissau between June 2018 and January 2020. A maximum life expectancy of around 14 months was observed (specifically 419 days for cuttlefishes from Morocco and 433 from Guinea-Bissau). The males presented greater longevity, as the maximum age of the females was between 9 and 11 months. Sepia bertheloti showed a negative allometric growth; however, the exponential model better describes each population growth. By sexes, the males of both locations followed an asymptotic growth model while the females exhibited a non-asymptotic growth. The growth rates were different between locations, with the highest values in Guinea-Bissau. The males, in turn, grew faster for both study locations. In Guinea-Bissau, these growth differences were influenced by the hatching season since individuals born between autumn and winter were the fastest-growing. Samples from Morocco did not show growth differences between the hatching season and other seasons. These results indicate that the RSS of lower beaks are suitable for estimating the age, growth pattern, and population structure of Sepia bertheloti.
Topological data analysis to identify cardiac resynchronization therapy patients exhibiting benefit from an implantable cardioverter-defibrillator
Authors: Veres Boglárka , Schwertner Walter Richard , Tokodi Márton , Szijártó Ádám , Kovács Attila , Merkel Eperke Dóra , Behon Anett , Kuthi Luca , Masszi Richárd , Gellér László , Zima Endre , Molnár Levente , Osztheimer István , Becker Dávid , Kosztin Annamária , Merkely Béla 
Published: August 2023

Abstract
Background
Current guidelines recommend considering multiple factors while deciding between cardiac resynchronization therapy with a defibrillator (CRT-D) or a pacemaker (CRT-P). Nevertheless, it is still challenging to pinpoint those candidates who will benefit from choosing a CRT-D device in terms of survival.

Objective
We aimed to use topological data analysis (TDA) to identify phenogroups of CRT patients in whom CRT-D is associated with better survival than CRT-P.

Methods
We included 2603 patients who underwent CRT-D (54%) or CRT-P (46%) implantation at Semmelweis University between 2000 and 2018. The primary endpoint was all-cause mortality. We applied TDA to create a patient similarity network using 25 clinical features. Then, we identified multiple phenogroups in the generated network and compared the groups’ clinical characteristics and survival.

Results
Five- and 10-year mortality were 43 (40–46)% and 71 (67–74)% in patients with CRT-D and 48 (45–50)% and 71 (68–74)% in those with CRT-P, respectively. TDA created a circular network in which we could delineate five phenogroups showing distinct patterns of clinical characteristics and outcomes. Three phenogroups (1, 2, and 3) included almost exclusively patients with non-ischemic etiology, whereas the other two phenogroups (4 and 5) predominantly comprised ischemic patients. Interestingly, only in phenogroups 2 and 5 were CRT-D associated with better survival than CRT-P (adjusted hazard ratio 0.61 [0.47–0.80], p < 0.001 and adjusted hazard ratio 0.84 [0.71–0.99], p = 0.033, respectively).

Conclusions
By simultaneously evaluating various clinical features, TDA may identify patients with either ischemic or non-ischemic etiology who will most likely benefit from the implantation of a CRT-D instead of a CRT-P.

Graphical abstract
Topological data analysis to identify phenogroups of CRT patients in whom CRT-D is associated with better survival than CRT-P. AF atrial fibrillation, CRT cardiac resynchronization therapy, CRT-D cardiac resynchronization therapy defibrillator, CRT-P cardiac resynchronization therapy pacemaker, DM diabetes mellitus, HTN hypertension, LBBB left bundle branch block, LVEF left ventricular ejection fraction, MDS multidimensional scaling, MRA mineralocorticoid receptor antagonist, NYHA New York Heart Association
Contributing factors for intraocular pressure control in patients with mostly normal-tension glaucoma after initial Ex-PRESS drainage device implantation
Authors: Aoyama Yurika , Sakata Rei , Fujishiro Takashi , Honjo Megumi , Shirato Shiroaki , Aihara Makoto 
Published: August 2023

Abstract
Purpose
To investigate the postoperative intraocular pressure (IOP) control and identify the factors associated with failure of initial Ex-PRESS surgery in patients with open-angle glaucoma for 3 years.

Methods
A total of 79 patients with medically uncontrolled open-angle glaucoma (55 normal-tension glaucoma and 24 primary open-angle glaucoma) were enrolled. All patients underwent Ex-PRESS implantation (including combined cataract surgery). The outcome measure was the survival rate using life table analysis, the failure was defined as IOP of > 18 mmHg (criterion A), > 15 mmHg (criterion B) or > 12 mmHg (criterion C) and/or IOP reduction of < 20% from baseline (each criterion) without any glaucoma medications. The Cox proportional hazards model was used to identify risk factors for IOP management defined as the above criterion.

Results
The mean preoperative IOP was 19.3 ± 5.8 mmHg. At 36 months, the mean IOP was 11.8 ± 3.6 mmHg with a mean IOP change of 7.5 mmHg (reduction rate 39.0%). The cumulative probability of success was 58% (95%CI: 42–64%) (criterion A), 48% (95%CI: 37–59%) (criterion B) and 30% (95%CI: 20–40%) (criterion C). In multivariate analyses, factors that predicted poor IOP control included the intervention of bleb needling after 6 months after the surgery (HR: 2.43; 95%CI: 1.35–4.37; P = 0.032). Transient hypotony was observed in 4 patients.

Conclusion
The implementation of bleb needling after Ex-PRESS surgery in the late postoperative period was suggested to be the main risk factor for achieving lower IOP.