bluuebunny/crossref_metadata_2025_split huggingface dataset:
SARS-CoV-2 infections in migrants and the role of household overcrowding: a causal mediation analysis of Virus Watch data
Authors: Boukari Yamina , Beale Sarah , Nguyen Vincent , Fong Wing Lam Erica , Burns Rachel , Yavlinsky Alexei , Hoskins Susan , Lewis Kate , Geismar Cyril , Navaratnam Annalan MD , Braithwaite Isobel , Byrne Thomas E , Oskrochi Youssof , Tweed Sam , Kovar Jana , Patel Parth , Hayward Andrew , Aldridge Robert 
Published: July 2023

BackgroundMigrants are over-represented in SARS-CoV-2 infections globally; however, evidence is limited for migrants in England and Wales. Household overcrowding is a risk factor for SARS-CoV-2 infection, with migrants more likely to live in overcrowded households than UK-born individuals. We aimed to estimate the total effect of migration status on SARS-CoV-2 infection and to what extent household overcrowding mediated this effect.MethodsWe included a subcohort of individuals from the Virus Watch prospective cohort study during the second SARS-CoV-2 wave (1 September 2020–30 April 2021) who were aged ≥18 years, self-reported the number of rooms in their household and had no evidence of SARS-CoV-2 infection pre-September 2020. We estimated total, indirect and direct effects using Buis’ logistic decomposition regression controlling for age, sex, ethnicity, clinical vulnerability, occupation, income and whether they lived with children.ResultsIn total, 23 478 individuals were included. 9.07% (187/2062) of migrants had evidence of infection during the study period vs 6.27% (1342/21 416) of UK-born individuals. Migrants had 22% higher odds of infection during the second wave (total effect; OR 1.22, 95% CI 1.01 to 1.47). Household overcrowding accounted for approximately 36% (95% CI −4% to 77%) of these increased odds (indirect effect, OR 1.07, 95% CI 1.03 to 1.12; proportion accounted for: indirect effect on log odds scale/total effect on log odds scale=0.36).ConclusionMigrants had higher odds of SARS-CoV-2 infection during the second wave compared with UK-born individuals and household overcrowding explained 36% of these increased odds. Policy interventions to reduce household overcrowding for migrants are needed as part of efforts to tackle health inequalities during the pandemic and beyond.
The longitudinal association between coupon receipt and established cigarette smoking initiation among young adults in USA
Authors: Siegel Leeann Nicole , Cook Steven , Oh Hayoung , Liber Alex C , Levy David T , Fleischer Nancy L 
Published: July 2023

IntroductionTobacco companies frequently distribute coupons for their products. This marketing tactic may be particularly effective among young adults, who tend to be especially price-sensitive. Young adulthood is also a stage during which many individuals initiate established cigarette smoking and are especially vulnerable to the effects of tobacco marketing.MethodsWe used five waves of data from the US Population Assessment on Tobacco and Health Study (2013–2019) to assess the longitudinal relationship between cigarette coupon receipt and initiation of established cigarette smoking among young adults (18–24 years) who did not report current smoking and had smoked <100 cigarettes in their lifetime at baseline. Initiation of established cigarette smoking was defined as reporting current cigarette use and having smoked ≥100 cigarettes at follow-up. To test this relationship, we fit four discrete time survival models to an unbalanced person-period data set. The first model included our time-varying coupon receipt variable, which was lagged one wave. Subsequent models added sociodemographic, cigarette smoking exposure and other tobacco use variables.ResultsAdopting the model adjusting for sociodemographic variables, respondents who received a coupon were found to be more likely to initiate established cigarette smoking at follow-up (adjusted HR (aHR): 2.31, 95% CI 1.41 to 3.80). This relationship remained significant when controlling for all covariates in the fully adjusted model (aHR: 1.96, 95% CI 1.18 to 3.26).ConclusionsThese findings show that receiving tobacco coupons may increase the likelihood that young adults will initiate established cigarette smoking, underscoring the need to address the effects of this tobacco marketing tactic.
Failure of tDCS to impact militarised threat-detection in a military cohort
Authors: Willmot Nicholas S. , Leow Li-Ann , Filmer Hannah L. , Dux Paul E. 
Published: July 2023

Abstract
Transcranial direct current stimulation (tDCS), a form of non-invasive brain stimulation, has become a focus of military organisations due to its reported positive effects on cognitive and motor performance. However, the majority of tDCS research in this space is conducted with civilian participants and/or uses abstract tasks. Additionally, of the small subset of studies that have used military participants or military-relevant tasks, few have employed both, and none with a considerable sample size. Here, we extend on previous work by exploring whether tDCS to the right inferior frontal gyrus (rIFG) enhances the performance of a large military cohort during a militaristic threat-detection task. 98 participants aged between 18 and 45 were randomly assigned to one of three conditions: (1) 2 mA anodal tDCS to the rIFG; (2) Sham stimulation to the rIFG; or (3) 2 mA anodal tDCS to the visual cortex (V1). Participants viewed serially presented, virtually generated militaristic images, and responded Yes/No via keypress to a threat being present. tDCS was applied for 25 min during the first two training blocks of the 50 min task. Results showed evidence for the null hypothesis: tDCS did not influence mean accuracy or reaction time across the task, in contrast to previous work. We discuss possible methodological and population factors that may explain why previously published effects of tDCS were not reproduced.
Commodifying Indigeneity? Settler Colonialism and Racial Capitalism in Fair Trade Farming in Palestine
Authors: Kirk Gabi 
Published: July 2023

Abstract
The recent proliferation of settler colonial and Indigenous studies of Palestine have addressed the historical and present-day enclosure of Palestinian land, yet the question of ‘indigeneity’ is underexamined in this literature. Claims to indigeneity in Palestine straddle varied definitions: a racial category; as constructed through the colonial encounter or preceding colonialism; and as a local relation or an international juridico-political category. Using discourse analysis and ethnography of a specific Palestinian sustainable agriculture initiative, I show how for Palestinians, claiming indigeneity brings into tension potential political economic gains, social relations of struggle, and discursive formations of collective subjectivity. A valorisation and commodification of indigeneity as a racial category narrows notions of indigeneity to the biological-cultural, offering challenges for Palestinian struggles for sovereignty. I conclude by asking what theorising from Palestine offers to Marxist theories of racial capitalism and settler colonialism, and whether indigeneity can exceed its commodification.
Dry-to-Wet Soil Gradients Enhance Convection and Rainfall over Subtropical South America
Authors: Chug Divyansh , Dominguez Francina , Taylor Christopher M. , Klein Cornelia , Nesbitt Stephen W. 
Published: July 2023

Abstract
Soil moisture–precipitation (SM–PPT) feedbacks at the mesoscale represent a major challenge for numerical weather prediction, especially for subtropical regions that exhibit large variability in surface SM. How does surface heterogeneity, specifically mesoscale gradients in SM and land surface temperature (LST), affect convective initiation (CI) over South America? Using satellite data, we track nascent, daytime convective clouds and quantify the underlying antecedent (morning) surface heterogeneity. We find that convection initiates preferentially on the dry side of strong SM/LST boundaries with spatial scales of tens of kilometers. The strongest alongwind gradients in LST anomalies at 30-km length scale underlying the CI location occur during weak background low-level wind (<2.5 m s−1), high convective available potential energy (>1500 J kg−1), and low convective inhibition (<250 J kg−1) over sparse vegetation. At 100-km scale, strong gradients occur at the CI location during convectively unfavorable conditions and strong background flow. The location of PPT is strongly sensitive to the strength of the background flow. The wind profile during weak background flow inhibits propagation of convection away from the dry regions leading to negative SM–PPT feedback whereas strong background flow is related to longer life cycle and rainfall hundreds of kilometers away from the CI location. Thus, the sign of the SM–PPT feedback is dependent on the background flow. This work presents the first observational evidence that CI over subtropical South America is associated with dry soil patches on the order of tens of kilometers. Convection-permitting numerical weather prediction models need to be examined for accurately capturing the effect of SM heterogeneity in initiating convection over such semiarid regions.
Identified eleven exon variants in PKD1 and PKD2 genes that altered RNA splicing by minigene assay
Authors: Liu Xuyan , Shi Xiaomeng , Xin Qing , Liu Zhiying , Pan Fengjiao , Qiao Dan , Chen Mengke , Zhang Yiyin , Guo Wencong , Li Changying , Zhang Yan , Shao Leping , Zhang Ruixiao 
Published: July 2023

Abstract
Background
Autosomal dominant polycystic kidney disease (ADPKD) is a common monogenic multisystem disease caused primarily by mutations in the PKD1 gene or PKD2 gene. There is increasing evidence that some of these variants, which are described as missense, synonymous or nonsense mutations in the literature or databases, may be deleterious by affecting the pre-mRNA splicing process.

Results
This study aimed to determine the effect of these PKD1 and PKD2 variants on exon splicing combined with predictive bioinformatics tools and minigene assay. As a result, among the 19 candidate single nucleotide alterations, 11 variants distributed in PKD1 (c.7866C > A, c.7960A > G, c.7979A > T, c.7987C > T, c.11248C > G, c.11251C > T, c.11257C > G, c.11257C > T, c.11346C > T, and c.11393C > G) and PKD2 (c.1480G > T) were identified to result in exon skipping.

Conclusions
We confirmed that 11 variants in the gene of PKD1 and PKD2 affect normal splicing by interfering the recognition of classical splicing sites or by disrupting exon splicing enhancers and generating exon splicing silencers. This is the most comprehensive study to date on pre-mRNA splicing of exonic variants in ADPKD-associated disease-causing genes in consideration of the increasing number of identified variants in PKD1 and PKD2 gene in recent years. These results emphasize the significance of assessing the effect of exon single nucleotide variants in ADPKD at the mRNA level.
Differentiating gastrointestinal tuberculosis and Crohn's disease- a comprehensive review
Authors: Choudhury Arup , Dhillon Jasdeep , Sekar Aravind , Gupta Pankaj , Singh Harjeet , Sharma Vishal 
Published: July 2023

AbstractGastrointestinal Tuberculosis (GITB) and Crohn’s disease (CD) are both chronic granulomatous diseases with a predilection to involve primarily the terminal ileum. GITB is often considered a disease of the developing world, while CD and inflammatory bowel disease are considered a disease of the developed world. But in recent times, the epidemiology of both diseases has changed. Differentiating GITB from CD is of immense clinical importance as the management of both diseases differs. While GITB needs anti-tubercular therapy (ATT), CD needs immunosuppressive therapy. Misdiagnosis or a delay in diagnosis can lead to catastrophic consequences. Most of the clinical features, endoscopic findings, and imaging features are not pathognomonic for either of these two conditions. The definitive diagnosis of GITB can be clinched only in a fraction of cases with microbiological positivity (acid-fast bacilli, mycobacterial culture, or PCR-based tests). In most cases, the diagnosis is often based on consistent clinical, endoscopic, imaging, and histological findings. Similarly, no single finding can conclusively diagnose CD. Multiparametric-based predictive models incorporating clinical, endoscopy findings, histology, radiology, and serology have been used to differentiate GITB from CD with varied results. However, it is limited by the lack of validation studies for most such models. Many patients, especially in TB endemic regions, are initiated on a trial of ATT to see for an objective response to therapy. Early mucosal response assessed at two months is an objective marker of response to ATT. Prolonged ATT in CD is recognized to have a fibrotic effect. Therefore, early discrimination may be vital in preventing the delay in the diagnosis of CD and avoiding a complicated course.
Negative associations between folate and bacterial vaginosis in the NHANES 2001 to 2004
Authors: Cui Ting-Ting , Luo Jing , Deng Rui-Lan , Yang Yun-Ting , Yin Ya-Wen , Chen Xing-Fei , Chen Hao-Kai , Liao Wan-Zhe , Huang Ze-Min , Deng Xiao-Yan , Guo Xu-Guang 
Published: July 2023

Abstract
Background
Bacterial vaginosis (BV) is one of the most common infections among women of reproductive age and accounts for 15–50% of infections globally. The role played by folate in the pathogenesis and progression of BV is poorly understood. The aim of this study was to investigate the association between serum folate, red blood cell (RBC) folate, and BV in American women.

Methods
1,954 participants from the 2001-2004 National Health and Nutrition Examination Survey (NHANES) program were included in this study. Multiple logistic regression was used to analyze the association between serum folate, RBC folate, and BV, and covariates including race, age, education level, and body mass index were used to construct adjusted models. Stratified analysis was used to explore the stability of the above associations in different populations.

Results
In the present cross-sectional study, we found that serum folate and RBC folate were inversely associated with the risk of BV. In the fully adjusted model, the risk of BV was reduced by 35% (OR=0.65, 95% CI: 0.51~0.83, p=0.0007) in the highest serum folate group and 32% (OR=0.68, 95% CI: 0.53~0.87, p=0.0023) in the highest RBC folate group compared to the lowest group.

Conclusions
The results of this study indicated that serum folate and RBC folate were inversely associated with the risk of BV folate supplementation may play an important role in the prevention and management of BV.
Assessing the influencing factors of out-of-pocket costs on tuberculosis in Sichuan Province: a cross-sectional study
Authors: Xia Lan , Gao Lijie , Zhong Yin , Wu Ya , He Jinge , Zou Fengjuan , Jian Ronghua , Xia Sujian , Chen Chuang , Zhu Sui 
Published: July 2023

Abstract
Background
Although diagnosis and treatment services for tuberculosis (TB) are provided free of charge in most countries, direct non-medical and indirect costs due to absenteeism, also place a significant burden on patients and their families. Sichuan Province has the second highest incidence of TB in China, with an incidence of approximately 100 cases per 100 000 people. However, there are limited research on out-of-pocket expenditure (OOPE) and its influencing factors in TB patients in Sichuan Province.

Methods
A retrospective cross-sectional study was conducted on TB patients in designated medical institutions for TB in Sichuan Province from 2017-2021. A face-to-face questionnaire was conducted to obtain the information related to hospitalization of patients, and the multi-level regression model was used to analyse the factors that influence OOPE and total out-of-pocket expenditure (TOOPE) of TB patients.

Results
A total of 2644 patients were investigated, and 74.24% of TB patients and their families experienced catastrophic total costs due to TB. The median total cost was 9223.37 CNY (1429.98 USD), in which the median direct and indirect costs of TB patients were 10185.00 CNY (1579.07 USD) and 2400.00 CNY (372.09 USD), respectively, and indirect costs contributed to 43% of total costs. The median OOPE and TOOPE costs were 6024.00 CNY (933.95 USD) and 11890.50 CNY (1843.49 USD), respectively. OOPE and TOOPE had common influencing factors including whether the patient's family had four or more members, a history of hospitalization, combination with other types of TB, the number of visits before diagnosis, and co-occurrence with chronic disease.

Conclusions
The OOPE and TOOPE for TB patients and their families in Sichuan Province are still heavy. In the long run, it is necessary to strengthen education and awareness campaigns on TB related knowledge, disseminate basic medical knowledge to the public, improve healthcare-seeking behavior, and enhance the healthcare infrastructure to improve the accuracy of TB diagnosis and reduce the significant OOPE and TOOPE faced by TB patients and their families in Sichuan Province.
Dietary patterns associated with colorectal cancer risk in the Malaysian population: a case–control study with exploratory factor and regression analysis
Authors: Abd Rashid Ainaa Almardhiyah , Ashari Lydiatul Shima , Shafiee Nor Hamizah , Raja Ali Raja Affendi , Yeong Yeh Lee , Shahril Mohd Razif , Jan Mohamed Hamid Jan 
Published: July 2023

Abstract
Background
Studies on the relationship between diet and colorectal cancer (CRC) risk using single food or nutrient approach are widely conducted as opposed to dietary pattern approach. Therefore, this study aimed to determine the major dietary patterns and their association with CRC risk among Malaysians.

Methods
Patients aged between 18 and 80 years old from two teaching hospitals in Peninsular Malaysia were recruited through purposive sampling. Socio-demographic information and anthropometry data were assessed before the colonoscopy procedure, and dietary intake was also recorded using a validated semi-quantitative food frequency questionnaire (FFQ). Cases were those patients having histopathologically proven CRC, while controls were those without.

Results
Four major dietary patterns were identified: the allergenic diet, plant-based diet, processed diet, and energy-dense diet pattern. After adjusting for potential covariates, the processed diet pattern was consistently associated with CRC (OR = 3.45; 95% CI = 1.25–9.52; P = 0.017) while the plant-based diet, energy-dense diet, and allergenic diet were not associated with CRC risk.

Conclusions
The processed diet pattern attributed to a diet high in confectionaries and fast foods was associated with an increased risk of CRC in the Malaysian population. In order to give prevention measures through lifestyle change, more research could be done on the effect of food patterns on faecal microbiota associated with CRC.
Imaging characteristics of tenosynovial giant cell tumors on 18F-fluorodeoxyglucose positron emission tomography/computed tomography: a retrospective observational study
Authors: Mizuta Kohei , Oshiro Hiromichi , Tsuha Yuichi , Tome Yasunori , Nishida Kotaro 
Published: July 2023

Abstract
Background
18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG-PET/CT) is useful for assessing location, metastasis, staging, and recurrence of malignant tumors. Tenosynovial giant cell tumor (TSGCT) is a benign tumor; however, some studies have reported that TSGCTs have a high uptake of FDG. Few studies have reported on the detailed evaluation of TSGCT using 18F-FDG-PET/CT. The purpose of the current study is to evaluate the image characteristics and locations, particularly where possible, with or without, extra-articular invasion from TSGCT of the knee in 18F-FDG-PET/CT could occur.

Methods
We retrospectively reviewed the patients with TSGCT who were diagnosed pathologically either by biopsy or surgical specimen. Furthermore, we evaluated the difference of the maximum standardized uptake value (SUVmax) between diffused TSGCT with extra-articular invasion and TSGCT with intra-articular localization in the knee.

Results
The study consisted of 20 patients with TSGCT. The mean SUVmax of TSGCT was 12.0 ± 6.50. There were five patients with TSGCT arising in the knee with extra-articular invasion and six with TSGCT with intra-articular localization. The mean SUVmax of TSGCT with extra-articular invasion and those with intra-articular localization were 14.3 ± 6.00 and 5.94 ± 3.89, respectively. TSGCT with extra-articular invasion had significantly higher SUVmax than TSGCT with intra-articular localization (p < 0.05).

Conclusions
TSGCT revealed high FDG uptake. Furthermore, SUVmax was higher in diffused TSGCT with extra-articular invasion than in intra-articular localized TSGCT; this may reflect its local aggressiveness.
Effect of an low-energy Nd: YAG laser on periodontal ligament stem cell homing through the SDF-1/CXCR4 signaling pathway
Authors: Wu Nan , Song Jianing , Liu Xin , Ma Xiangtao , Guo Xiaoman , Liu Taohong , Wu Mingxuan 
Published: July 2023

Abstract
Background
The key to the success of endogenous regeneration is to improve the homing rate of stem cells, and low-energy laser is an effective auxiliary means to promote cell migration and proliferation. The purpose of this study was to observe whether low-energy neodymium (Nd: YAG) laser with appropriate parameters can affect the proliferation and migration of periodontal ligament stem cells (PDLSCs) through SDF-1/CXCR4 pathway.

Methods
h PDLSCs were cultured and identified. CCK8 assay was used to detect the proliferation of h PDLSCs after different power (0, 0.25, 0.5, 1, and 1.5 W) Nd: YAG laser (MSP, 10 Hz, 30 s, 300 μ m) irradiation at 2th, 3rd,5th, and 7th days, and the optimal laser irradiation parameters were selected for subsequent experiments. Then, the cells were categorized into five groups: control group (C), SDF-1 group (S), AMD3100 group (A), Nd: YAG laser irradiation group (N), and Nd: YAG laser irradiation + AMD3100 group (N + A). the migration of h PDLSCs was observed using Transwell, and the SDF-1 expression was evaluated using ELISA andRT-PCR. The SPSS Statistics 21.0 software was used for statistical analysis.

Results
The fibroblasts cultured were identified as h PDLSCs. Compared with the C, when the power was 1 W, the proliferation rate of h PDLSCs was accelerated (P < 0.05). When the power was 1.5 W, the proliferation rate decreased (P < 0.05). When the power was 0.25 and 0.5 W, no statistically significant difference in the proliferation rate was observed (P > 0.05). The number of cell perforations values as follows: C (956.5 ± 51.74), A (981.5 ± 21.15), S (1253 ± 87.21), N (1336 ± 48.54), and N + A (1044 ± 22.13), that increased significantly in group N (P < 0.05), but decreased in group N + A (P < 0.05). The level of SDF-1 and the expression level of SDF-1 mRNA in groups N and N + A was higher than that in group C (P < 0.05) but lower than that in group A (P < 0.05).

Conclusions
Nd: YAG laser irradiation with appropriate parameters provides a new method for endogenous regeneration of periodontal tissue. SDF-1/CXCR4 signaling pathway may be the mechanism of LLLT promoting periodontal regeneration.