bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hubungan Karakteristik Keluarga dengan Status Gizi (BB/TB) Anak Usia 6-24 Bulan di Wilayah Kerja Puskesmas Titi Papan Kota Medan
Authors: Rukmana Erni , Purba Rasita , Nurfazriah Latifah Rahman , Purba Edy Marjuang , Fransiari Muhammad Edwin 
Published: April 2023

The nutritional status of children under five is an indicator of healthy growth in the community. Indicators of nutritional status of body weight according to height are to identify the poor, malnourished, good, and obese nutritional status. Nutritional status is influenced by individual and family characteristics. The purpose of this study to analyzed the relationship between family characteristics and the nutritional status of children aged 6-24 months in the working area of the Titi Papan Public Health Center, Medan City. This research method used a cross-sectional design and was carried out from June to July 2022. The sampling technique used random sampling as many as 98 children aged 6-24 months. The independent variables of this study were age, birth weight, birth length, family size, and family income. The dependent variable of this study was nutritional status based on weight according to height. Spearman test was used to determine the correlation between the independent and dependent variables. The results of the study were significant relationship of nutritional status between birth weight (p=0.04) and family size (p=0.02). The size of the family related to the growth and development of children, so it was the important information for publicity that there was relationship between family characteristics and nutritional status. Therefore, birth weight related to children nutritional status based on index of weight for height.
CATCH MARRIAGE IN MAQASHID AL-SYARI'AH AND INDONESIAN LAW PERSPECTIVE
Authors: Amin Habibi Al , Muhdi Muhdi 
Published: April 2023

This article is the result of a qualitative field research with a legal sociology approach. This article discusses the tradition of intermarrying with the eyes of Islamic law and positive law. The researcher uses the maqasid shariah theory in explaining the legal position of capture marriage. The maqasid shariah theory has a flexible and adaptive character in determining the legal status of localistic matters. The location of this research is in Pekalongan village, Sampang district, Madura. This study concludes that marriage arrests in the village of Pekalongan are legal, even obligatory, seeing that the implementation of the marriage arrest law cannot be separated from the main purpose of implementing Islamic laws. Capture marriage fulfills the maqashid al-sharī'ah element. Capture marriages function as hifd al din, namely tradition as religious social control, as a social protection system that fulfills the elements of hifdh an-nafs (avoiding cases of violence and vigilantism), hifdh an-nasl (avoiding offspring from illicit relationships), hifdh al-mal (avoiding the use of money in vain), hifdh al-aql (maintaining a healthy mindset and avoiding depression). Capture marriages are marriages that have no legal force because they are not registered..
Keywords: kawin tangkap tradition, maqasid shariah, law
DAFTAR PUSTAKA
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SUNDANESE MARRIAGE CUSTOM IN ISLAMIC LAW PERSPECTIVE
Authors: Putri Bunga Nurwiyatin , Nawawi Ruston 
Published: April 2023

This article is the result of a qualitative field research. This article discusses a series of Sundanese traditional marriages from the perspective of Islamic law. The research location is in Caringin Village, Tegal Panjang Village, Sucinarja District, Garut Regency. This study concludes that the series of Sundanese traditional wedding ceremonies are not in conflict with fiqh law. The series consists of a) pre-marriage stage; b) stage of the marriage contract; and c) post-marriage contract stage. The three sets of Sundanese marriage traditions are in harmony with the law of fiqh. This argument is built by analyzing the three series with the jurisprudence of the four schools of thought, istihsan bi maqasid al-shariah, isthsan bi al'urf, and the text of the argument.
Keywords: Sundanese traditional marria, Islamic law, urf, maqasid shari’ah

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‘Abidin, Ibnu. Roddul Mukhtar Ala Daril Mukhtar Syarah Tanwirul Absar Fiqhu Abu Hanabiyah, Muktabah Syamila.

Abdillah, Imam Abi. 1994. Shahih Bukhari. Beirut : Dar Al-fikr.

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Amin, H. A., Masrokhin, M., & Anwar, K. (2021). GUARDIANS CONCEPT IN QUR’AN PERSPECTIVE . SHAKHSIYAH BURHANIYAH: Jurnal Penelitian Hukum Islam , 6(1), 95 - 114. https://doi.org/10.33752/sbjphi.v6i1.1642

Al-Asfihani, Al-Garib. Ttp. Mufradat al-Fash al-Qur’an. Dar al-Katibal-‘Arabi.

Al-Asqalani, Ibnu Hajar. 2011. Bulughul Maram. Jakarta: Pustaka as-Sunnah.

Al-Jaziri, Abdurrahman. 1986. Kitab ‘ala Mazahib Al-Arba’ah Juz IV. Dar ihya al-Turas al-Arabi.

As-Shabuni, Muhammad Ali. 1972. Tafsir Ayat al-Ahkam min al-Qur’an. Kuwait: Dar al-Qur’an al-Karim.

As-Syuti, Abdurrahman Jalaluddin. 1983. Al-Asybah wa an-Naza’ir fi Qawa’id wa Furu’ Fiqh asy Syafi’i. Beirut: Dar al-Kutub al-‘Ilmiyah.

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Az-zukhaili, Wahbah. Ushul Fiqh al-Islami. Juz 2. Damaskus: Dar al-fikr

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Selling Orientation – Customer Orientation (S.O.C.O): Hubungan Penerapannya Dalam Meningkatkan Kinerja Pemasaran Usaha Ritel Modern di Kota Pontianak
Authors: Santika Dewi 
Published: April 2023

The aim of this research for build a framework conceptual about connection from implementation of Selling Orientation and Customer Orientation (SOCO) strategies as modern retail in Pontianak City for increase marketing performance. Population in this research is modern retail outlets in Pontianak City, totaling 227 outlets. Determination technique amount sample using multivariate technique with minimum sample 50 respondents and maximum sample 80 respondents. Data collection with interview and dissemination questionnaire. The results show that selling orientation has an effect negative and significant to enhancement marketing performance, meaning if modern retail run a selling orientation strategy as well won’t automatically increase marketing performance of their business. Compare backwards with customer orientation based on multiple linear regression test and t test shows influence positive and significant in effort increase marketing performance for modern retail in Pontianak City. Conclusion show that the more good implementation of customer orientation strategy could increase marketing performance effort modern retail in Pontianak City.
Abstrak
Penelitian ini bertujuan untuk membangun sebuah kerangka konseptual mengenai hubungan dari penerapan strategi Selling Orientation dan Customer Orientation (S.O.C.O) sebagai upaya pelaku usaha ritel di Kota Pontianak untuk meningkatkan kinerja penjualnya. Populasi dalam penelitian ini adalah pelaku usaha ritel modern di Kota Pontianak yang berjumlah 227 gerai. Teknik penentuan jumlah sampel menggunakan Teknik multivariate dengan jumlah sampel minimum 50 responden dan jumlah sampel maksimum 80 responden. Teknik pengumpulan data melalui wawancara dan penyebaran kuesioner. Hasil uji regresi linier berganda dan uji t menunjukkan bahwa selling orientation berpengaruh negatif dan signifikan terhadap peningkatan kinerja pemasaran, artinya jika pelaku usaha ritel modern menjalankan strategi selling orientation tidak serta merta dapat meningkatkan kinerja pemasaran usahanya. Berbanding terbalik dengan customer orientation yang justru menunjukkan pengaruh positif dan signifikan dalam upaya meingkatkan kinerja pemasaran usaha ritel modern di Kota Pontianak. Simpulan penelitian menyatakan semakin baik penerapan strategi customer orientation maka dapat meningkatkan kinerja pemasaran usaha ritel modern di Kota Pontianak.
Kata Kunci: Selling Orientation, Customer Orientation, Kinerja Pemasaran
Is valve-sparing aortic root replacement better than total aortic root replacement? An overview of reviews
Authors: Wang Wei , Zhang Xuezhou , Shi Yong , Xu Siqi , Shi Teng , Han Xiaotian , Gu Tianxiang , Shi Enyi 
Published: April 2023

BackgroundTotal aortic root replacement (TRR) is certainly beneficial for aortic root disease, but does it still have an advantageous prognosis for patients compared to valve-sparing aortic root replacement (VSRR)? An overview of reviews was conducted to assess each of their clinical efficacy/effectiveness.Review methodsSystematic reviews (SRs)/Meta-analyses comparing the prognosis of TRR and VSRR in aortic root surgery were collected from 4 databases, all searched from the time of database creation to October 2022. Two evaluators independently screened the literature, extracted information and applied the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement, A Measurement Tool to Assess Systematic Reviews 2 (AMSTAR 2) tool, Grading of Recommendations, Assessment, Development and Evaluations (GRADE), and Risk of Bias in Systematic Reviews (ROBIS) to evaluate the quality of reporting, methodological quality, risk of bias, and level of evidence of the included studies.Main resultsA total of 9 SRs/Meta-analyses were ultimately included. In terms of the reporting quality of the included studies, PRISMA scores ranged from 14 to 22.5, with issues mainly in reporting bias assessment, risk of study bias, credibility of evidence, protocol and registration, and funding sources. The methodological quality of the included SRs/Meta-analyses was generally low, with key items 2, 7, and 13 having major flaws and non-key items 10, 12, and 16. In terms of risk of bias assessment, the overall assessment of the included 9 studies was high-risk. The quality of the evidence was rated as low to very low quality for the three outcome indicators selected for the GRADE quality of evidence rating: early (within 30 days postoperatively or during hospitalization) mortality, late mortality, and valve reintervention rate.ConclusionsVSRR has many benefits including reduced early and late mortality after aortic root surgery and reduced rates of valve-related adverse events, but the methodological quality of the relevant studies is low, and there is a lack of high-quality evidence to support this.Systematic Review Registrationhttps://www.PROSPERO, identifier: CRD42022381330.
Multilevel comparison of deep learning models for function quantification in cardiovascular magnetic resonance: On the redundancy of architectural variations
Authors: Ammann Clemens , Hadler Thomas , Gröschel Jan , Kolbitsch Christoph , Schulz-Menger Jeanette 
Published: April 2023

BackgroundCardiac function quantification in cardiovascular magnetic resonance requires precise contouring of the heart chambers. This time-consuming task is increasingly being addressed by a plethora of ever more complex deep learning methods. However, only a small fraction of these have made their way from academia into clinical practice. In the quality assessment and control of medical artificial intelligence, the opaque reasoning and associated distinctive errors of neural networks meet an extraordinarily low tolerance for failure.AimThe aim of this study is a multilevel analysis and comparison of the performance of three popular convolutional neural network (CNN) models for cardiac function quantification.MethodsU-Net, FCN, and MultiResUNet were trained for the segmentation of the left and right ventricles on short-axis cine images of 119 patients from clinical routine. The training pipeline and hyperparameters were kept constant to isolate the influence of network architecture. CNN performance was evaluated against expert segmentations for 29 test cases on contour level and in terms of quantitative clinical parameters. Multilevel analysis included breakdown of results by slice position, as well as visualization of segmentation deviations and linkage of volume differences to segmentation metrics via correlation plots for qualitative analysis.ResultsAll models showed strong correlation to the expert with respect to quantitative clinical parameters (rz′ = 0.978, 0.977, 0.978 for U-Net, FCN, MultiResUNet respectively). The MultiResUNet significantly underestimated ventricular volumes and left ventricular myocardial mass. Segmentation difficulties and failures clustered in basal and apical slices for all CNNs, with the largest volume differences in the basal slices (mean absolute error per slice: 4.2 ± 4.5 ml for basal, 0.9 ± 1.3 ml for midventricular, 0.9 ± 0.9 ml for apical slices). Results for the right ventricle had higher variance and more outliers compared to the left ventricle. Intraclass correlation for clinical parameters was excellent (≥0.91) among the CNNs.ConclusionModifications to CNN architecture were not critical to the quality of error for our dataset. Despite good overall agreement with the expert, errors accumulated in basal and apical slices for all models.
Different hemodynamic factors cause the occurrence of superior mesenteric atherosclerotic stenosis and superior mesenteric artery dissection
Authors: Mei Junhao , Ding Wei , Yu Haiyang , Zhao Xi , Xu Haoran , Wang Kai , Jia Zhongzhi , Li Benling 
Published: April 2023

ObjectiveTo compare the hemodynamic factors involved in the occurrence of superior mesenteric atherosclerotic stenosis (SMAS) and superior mesenteric artery (SMA) dissection (SMAD).MethodsHospital records were searched to identify consecutive patients who were diagnosed with SMAS or SMAD between January 2015 and December 2021. A computational fluid dynamics (CFD) simulation method was used to assess the hemodynamic factors of the SMA in these patients. Histologic analysis was also performed on SMA specimens obtained from 10 cadavers, and scanning electron microscopy was used to evaluate collagen microstructure.ResultsA total of 124 patients with SMAS and 61 patients with SMAD were included. Most SMASs were circumferentially distributed at the SMA root, whereas the origin of most SMADs was located on the anterior wall of the curved segment of the SMA. Vortex, higher turbulent kinetic energy (TKE), and lower wall shear stress (WSS) were observed near plaques; higher TKE and WSS were seen near dissection origins. The intima in the SMA root (388.5 ± 202.3 µm) was thicker than in the curved (243.8 ± 100.5 µm; p = .007) and distal (183.7 ± 88.0 µm; p &lt; .001) segments. The media in the anterior wall (353.1 ± 37.6 µm) was thinner than that in the posterior wall (473.7 ± 142.8 µm; p = .02) in the curved segment of the SMA. The gaps in the lamellar structure in the SMA root were larger than in the curved and distal segments. The collagen microstructure was more substantially disturbed in the anterior wall than in the posterior wall in the curved segment of the SMA.ConclusionDifferent hemodynamic factors in different portions of the SMA are related to local pathological changes in the SMA wall and may lead to the occurrence of SMAS or SMAD.
Predicting enhancer-promoter interaction based on epigenomic signals
Authors: Zheng Leqiong , Liu Li , Zhu Wen , Ding Yijie , Wu Fangxiang 
Published: April 2023

Introduction: The physical interactions between enhancers and promoters are often involved in gene transcriptional regulation. High tissue-specific enhancer-promoter interactions (EPIs) are responsible for the differential expression of genes. Experimental methods are time-consuming and labor-intensive in measuring EPIs. An alternative approach, machine learning, has been widely used to predict EPIs. However, most existing machine learning methods require a large number of functional genomic and epigenomic features as input, which limits the application to different cell lines.Methods: In this paper, we developed a random forest model, HARD (H3K27ac, ATAC-seq, RAD21, and Distance), to predict EPI using only four types of features.Results: Independent tests on a benchmark dataset showed that HARD outperforms other models with the fewest features.Discussion: Our results revealed that chromatin accessibility and the binding of cohesin are important for cell-line-specific EPIs. Furthermore, we trained the HARD model in the GM12878 cell line and performed testing in the HeLa cell line. The cross-cell-lines prediction also performs well, suggesting it has the potential to be applied to other cell lines.
MYBL2 alternative splicing-related genetic variants reduce the risk of triple-negative breast cancer in the Chinese population
Authors: Chen Xinyu , Feng Jin , Zhang Yuan , Liu Jiarui , Zhang Lijia , Zeng Pu , Wen Langbo , Wang Xin , Zhang Yi 
Published: April 2023

Background: Triple-negative breast cancer (TNBC) is the most malignant subtype of breast cancer, and studies have found an association between the Myb proto-oncogene like 2 (MYBL2) gene and TNBC development; however, the specific mechanisms underlying development remain unknown. Recent studies have reported the association of alternative splicing (AS) with cancer, providing new approaches to elucidate the carcinogenesis mechanism. This study aimed to identify MYBL2 AS-related genetic variants that influence the risk of developing TNBC, providing new ideas for probing the mechanism of TNBC and novel biomarkers for TNBC prevention.Methods: We conducted a case-control study of 217 patients with TNBC and 401 cancer-free controls. The CancerSplicingQTL database and HSF software were used to screen for MYBL2 AS-related genetic variants. The association of sample genotypes with the risk of TNBC development and with clinicopathological features was analysed via unconditional logistic regression. Combining multiple platforms, the candidate sites were subjected to biological function analysis.Results: Two AS-associated SNPs, rs285170 and rs405660, were identified using bioinformatics analysis. Logistic regression analysis showed that both rs285170 (OR = 0.541; 95% CI = 0.343–0.852; p = 0.008) and rs405660 (OR = 0.642; 95% CI = 0.469–0.879; p = 0.006) exhibited protective effects against TNBC under the additive model. Stratification analysis showed that these two SNPs had more significant protective effects in the Chinese population aged ≧50 years. Additionally, we found that rs405660 was associated with the risk of lymph node metastasis (OR = 0.396, 95% CI = 0.209–0.750, p = 0.005) in TNBC. Functional analysis revealed that both rs285170 and rs405660 are associated with splicing of exon 3 and that the exon 3-deleted spliceosome does not increase breast cancer risk.Conclusion: We found for the first time that MYBL2 AS-related genetic variants are associated with reduced TNBC susceptibility in the Chinese population, especially in women aged ≧50 years.
Insights into IGH clonal evolution in BCP-ALL: frequency, mechanisms, associations, and diagnostic implications
Authors: Darzentas Franziska , Szczepanowski Monika , Kotrová Michaela , Hartmann Alina , Beder Thomas , Gökbuget Nicola , Schwartz Stefan , Bastian Lorenz , Baldus Claudia Dorothea , Pál Karol , Darzentas Nikos , Brüggemann Monika 
Published: April 2023

IntroductionThe malignant transformation leading to a maturation arrest in B-cell precursor acute lymphoblastic leukemia (BCP-ALL) occurs early in B-cell development, in a pro-B or pre-B cell, when somatic recombination of variable (V), diversity (D), and joining (J) segment immunoglobulin (IG) genes and the B-cell rescue mechanism of VH replacement might be ongoing or fully active, driving clonal evolution. In this study of newly diagnosed BCP-ALL, we sought to understand the mechanistic details of oligoclonal composition of the leukemia at diagnosis, clonal evolution during follow-up, and clonal distribution in different hematopoietic compartments.MethodsUtilizing high-throughput sequencing assays and bespoke bioinformatics we identified BCP-ALL-derived clonally-related IGH sequences by their shared ‘DNJ-stem’.ResultsWe introduce the concept of ‘marker DNJ-stem’ to cover the entirety of, even lowly abundant, clonally-related family members. In a cohort of 280 adult patients with BCP-ALL, IGH clonal evolution at diagnosis was identified in one-third of patients. The phenomenon was linked to contemporaneous recombinant and editing activity driven by aberrant ongoing DH/VH-DJH recombination and VH replacement, and we share insights and examples for both. Furthermore, in a subset of 167 patients with molecular subtype allocation, high prevalence and high degree of clonal evolution driven by ongoing DH/VH-DJH recombination were associated with the presence of KMT2A gene rearrangements, while VH replacements occurred more frequently in Ph-like and DUX4 BCP-ALL. Analysis of 46 matched diagnostic bone marrow and peripheral blood samples showed a comparable clonal and clonotypic distribution in both hematopoietic compartments, but the clonotypic composition markedly changed in longitudinal follow-up analysis in select cases. Thus, finally, we present cases where the specific dynamics of clonal evolution have implications for both the initial marker identification and the MRD monitoring in follow-up samples.DiscussionConsequently, we suggest to follow the marker DNJ-stem (capturing all family members) rather than specific clonotypes as the MRD target, as well as to follow both VDJH and DJH family members since their respective kinetics are not always parallel. Our study further highlights the intricacy, importance, and present and future challenges of IGH clonal evolution in BCP-ALL.