bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pediatric paragonimiasis: a retrospective analysis of cases from a county in south-west China
Authors: Jiang Yong-xin , Li Gong-qiang , Pan Cheng-jing , He Zhong-qiu , Wang Chao , Mu Qi-ru , Cao Lu-lu 
Published: May 2023

IntroductionThe clinical manifestations of paragonimiasis are diverse and non-specific, and can easily lead to misdiagnosis. We aimed to analyze the clinical manifestations, laboratory features, treatment, and clinical outcome of children with paragonimiasis in order to improve recognition of this disease and avoid misdiagnosis.MethodsChildren diagnosed with paragonimiasis from August 2016 to July 2022 were included in the study. Information on population informatics, medical history, and laboratory features was extracted from case data. The clinical features of paragonimiasis were retrospectively analyzed.ResultsA total of 45 children were included in this study. All children had, at least, one risk factor. The clinical features mainly included fever, cough, pleural effusion, peritoneal effusion, and subcutaneous nodules. The main imaging findings were alveolar exudation, peritoneal effusion, pleural thickening, and local nodules. The “tunnel sign” finding on computed tomography (CT)/magnetic resonance imaging (MRI) was helpful in establishing the diagnosis of paragonimiasis. After praziquantel treatment, most of the children improved, and one child with cerebral paragonimiasis experienced sequelae.ConclusionMost children with paragonimiasis have a good prognosis, but few children can experience sequelae. Avoidance of untreated water and raw food is a simple, feasible, and effective preventive measure.
Leuprolide and triptorelin treatment in children with idiopathic central precocious puberty: an efficacy/tolerability comparison study
Authors: Valenzise M. , Nasso C. , Scarfone A. , Rottura M. , Cafarella G. , Pallio G. , Visalli G. , Di Prima E. , Nasso E. , Squadrito V. , Wasniewska M. , Irrera P. , Arcoraci V. , Squadrito F. 
Published: May 2023

IntroductionCentral precocious puberty (CPP) results from premature activation of hypothalamic-pituitary-gonadal axis, with the consequent increase of gonadotropin-releasing hormone (GnRH); GnRH agonists (GnRHa) represent the gold-standard therapy in children with CPP although their use might be responsible for pituitary GnRH receptors down-regulation, that in turn suppresses luteinizing hormone (LH) and follicle stimulating hormone (FSH) and blocks of gonadal sex hormones release. The most prescribed GnRHa in the clinical practice are leuprolide and triptorelin, whose use is generally safe and well tolerated; however, mild menopausal-like side effects could appear. The aim of the present study was to investigate and compare the efficacy and tolerability profile of leuprolide and triptorelin in CPP patients.Methods110 girls affected by CPP were enrolled in this retrospective study, carried out from 2018 to 2020. The enrolled patients received leuprolide (n = 48) or triptorelin (n = 62). Efficacy was investigated by the means of clinical parameters and radiological changes and side effects were also recorded to evaluate the possible relationship between the two GnRHa treatments and side effects appearance.ResultsAt baseline triptorelin patients had significantly higher LH and LH peak levels than leuprolide patients, whereas no significant difference in other patient characteristics was observed between the two groups. The leuprolide treatment lasted 971 days [790–1,171 days] while the duration of triptorelin administration was 792 days [760–1,003 days] (p &lt; 0.001). Overall 46 (41.8%) of the studied patients reported mild menopausal-like symptoms: among these 27 were treated with triptorelin and 19 with leuprolide (p = 0.558). Patients treated with triptorelin, or leuprolide showed headache (27.4% vs. 16.7%), mood swings (12.9% vs. 16.7%), increased appetite (12.9% vs. 18.8%) and nausea (1.6% vs. 10.4%) respectively. Moreover, the onset of side effects appearance related to GnRHa therapy significantly reduces with the increase of the initial bone age (p = 0.038).ConclusionLeuprolide and triptorelin treatment appear to be effective and safe without significant difference between the two drugs in term of efficacy and tolerability, making both good options for treating CPP.
A randomized, double-blind pilot study of analgesic and anti-inflammatory effects of naproxen sodium and acetaminophen following dental implant placement surgery
Authors: Theken Katherine N. , Chen Mengxiang , Wall D. Lucas , Pham Truongan , Secreto Stacey A. , Yoo Thomas H. , Rascon Allison N. , Chang Yu-Cheng , Korostoff Jonathan M. , Mitchell Claire H. , Hersh Elliot V. 
Published: May 2023

Introduction: Post-surgical pain following dental implant placement surgery is typically managed with non-opioid analgesics, including non-steroidal anti-inflammatory drugs (NSAIDs) and acetaminophen. However, the comparative analgesic efficacy of over-the-counter doses of non-steroidal anti-inflammatory drugs and acetaminophen in implant patients is unknown. Therefore, we compared the analgesic and anti-inflammatory effects of naproxen sodium and acetaminophen after surgical placement of one or two dental implants.Methods: Adult patients were treated with naproxen sodium (440 mg loading dose +220 mg q8h, n = 15) or acetaminophen (1,000 mg q6h—max daily dose 3,000 mg, n = 15) for 3 days after implant placement in a randomized, double-blind design. Pain was assessed on a 0–10 scale every 20 min for 6 h after study medication treatment. Tramadol (50 mg) was available as a rescue medication. Plasma and gingival crevicular fluid (GCF) were collected prior to the surgery and 0, 1, 2, 4, 6, 24, and 72 h after surgery for quantification of interleukin (IL)-6, IL-8, and IL-1β levels.Results: Pain scores were significantly lower in patients treated with naproxen sodium compared to those treated with acetaminophen. Inflammatory mediator levels in plasma and gingival crevicular fluid increased after surgery and returned to near baseline levels by 72 h. Plasma IL-6 levels were significantly lower 6 h after surgery in patients treated with naproxen sodium compared to acetaminophen. No differences in inflammatory mediator concentrations in gingival crevicular fluid were observed between the treatment groups. The number of implants placed and body mass index (BMI) influenced inflammatory mediator concentrations in plasma and gingival crevicular fluid, respectively.Discussion: Naproxen sodium was more effective than acetaminophen in reducing post-operative pain and systemic inflammation following surgical placement of one or two dental implants. Further studies are needed to determine whether these findings are applicable to more complex implant cases and how they affect clinical outcomes following implant placement.Clinical Trial Registration:ClinicalTrials.gov, identifier NCT04694300
A single-center initial experience on laparoscopic pancreatic operation combined with hepatic arterial resection and reconstruction
Authors: Xu Jie , Wang Jia-Guo , Lei Kai , Liu Zuo-Jin 
Published: May 2023

ObjectiveThis study aims to summarize our single-center initial experience in laparoscopic pancreatic operation (LPO) combined with hepatic arterial resection and reconstruction, as well as to demonstrate the feasibility, safety, and key surgical procedure for LPO.MethodsWe retrospectively analyzed 7 patients who had undergone LPO combined with hepatic arterial resection and reconstruction in our center from January 2021 to December 2022. The clinical data of these 7 patients were collected and analyzed.ResultsIn our case series, two patients underwent passive arterial resection and reconstruction due to iatrogenic arterial injury, and five patients underwent forward arterial resection and reconstruction due to arterial invasion. The arterial anastomosis was successful in 5 cases, including 2 cases of end-to-end in situ and 3 cases of arterial transposition, and the vascular reconstruction time was 38.28 ± 15.32 min. There were two conversions to laparotomy. The postoperative recovery of all patients was uneventful, with one liver abscess (Segment 4) and no Clavien III–IV complications. We also share valuable technical feedback and experience gained from the initial practice.ConclusionsBased on the surgeon's proficiency in open arterial resection and reconstruction and laparoscopic technique. This study demonstrated the feasibility of total laparoscopic hepatic arterial resection and reconstruction in properly selected cases of arterial involvement or iatrogenic arterial injury. Our initial experience provides valuable information for laparoscopic pancreas surgery with arterial resection and reconstruction.
Thermal Conductivity of Polyvinylidene Fluoride Films with a Multi-Scale Framework
Authors: Wang Qin , Liu Shixin , Guo Hong , Hu Boyang , Li Yi , Wang Jixiao , Li Baoan 
Published: May 2023

The orientation of amorphous regions in pure polymers has been noted to be critical to the enhancement of thermal conductivity (TC), but the available reports are still rather few. Here, we propose to prepare a polyvinylidene fluoride (PVDF) film with a multi-scale framework by introducing anisotropic amorphous nanophases in the form of cross-planar alignments among the in-planar oriented extended-chain crystals (ECCs) lamellae, which show an enhanced TC of 1.99 Wm−1 K−1 in the through-plane direction (K⊥) and 4.35 Wm−1 K−1 in the in-plane direction (K∥). Structural characterization determination using scanning electron microscopy and high-resolution synchrotron X-ray scattering showed that shrinking the dimension of the amorphous nanophases can effectively reduce entanglement and lead to alignments formation. Moreover, the thermal anisotropy of the amorphous region is quantitatively discussed with the aid of the two-phase model. Superior thermal dissipation performances are intuitively displayed by means of finite element numerical analysis and heat exchanger applications. Moreover, such unique multi-scale architecture also results in significant benefit in the improvement of dimensional stability and thermal stability. This paper provides a reasonable solution for fabricating inexpensive thermal conducting polymer films from the perspective of practical applications.
A long-term follow-up of observation in treatment-free remission in patients with chronic myeloid leukemia
Authors: Petrova A. N. , Chelysheva E. Yu. , Nemchenko I. S. , Bykova A. V. , Gurianova M. A. , Kuzmina E. A. , Tsyba N. N. , Kokhno A. V. , Turkina A. G. 
Published: May 2023

Introduction. The option of observation without therapy with tyrosine kinase inhibitors (TKIs) in chronic myeloid leukemia (CML) patients is already included in Russian and international clinical guidelines. Evaluation of long-term follow-up results of treatment free remission (TFR) in CML patients is relevant for the introduction of this approach into routine clinical practice. Aim — to demonstrate the outcomes in a long-term follow-up of CML patients who discontinued TKI therapy in the RU-SKI trial. Patients and methods. The prospective study included 98 CML patients with TKI therapy duration ≥ 3 years and a deep molecular response (DMR, BCR::ABL1 ≤ 0.01 %) duration ≥ 2 years. TKI therapy was resumed with the loss of a major MR (MMR, BCR::ABL1 > 0,1 %). Results. Median time of follow-up after TKI discontinuation was 64 months (range of 51–86 months). Survival without MMR loss at 3 and 5 years after TKI discontinuation was 51 % (CI 41–61 %) and 46 % (CI 36–57 %) respectively. From 3 to 5 years of follow-up without therapy, the loss of MMR occurred in 2 (4 %) patients. There was no MMR loss observed after 5 years of follow-up. In patients with first and second treatment discontinuation, survival without MMR loss was 50 % versus 12,5 %(р = 0,039). All 50 patients with molecular relapses regained MMR and MR4 after TKI therapy resumption. BCR::ABL1 level fluctuations 0,01–0,1 % were in 62 % (n = 29) patients, who were in TFR at the time of analysis. Loss of MR4 was observed in 38 (42 %) from 90 patients with first TKI discontinuation. Survival without MMR loss from MO4 loss was 24 % at 5 years after TKI discontinuation. Loss of MO4 in the first 3 months after TKI cessation was associated with a high probability of further MMR loss (8 % versus 54 % in patients with loss of MO4 for > 3 months, p = 0.00015). Conclusion. The low frequency of late relapses (4 % after 3 years of follow-up) and the possibility of long-term persistence of minimal residual disease (MRD) after discontinuation of therapy determine the need to optimize the timing of molecular monitoring, taking into account the MRD status of patients.
Thromboelastometry for predicting hemostasis disorders after cardiopulmonary bypass during cardiac surgery
Authors: Akselrod B. A. , Dymova O. V. , Guskov D. A. , Goncharova A. V. , Gladysheva V. G. , Tolstova I. A. , Linnik D. V. 
Published: May 2023

Introduction. Assessment of the state of the hemostasis system in cardioanesthesiology is carried out both clinically and using standard laboratory tests — thromboelastography (TEG), rotational thromboelastometry (ROTEM), or a combination of both. Both TEG and ROTEM are designed to detect disorders in the hemostasis system in real time. Aim – to evaluate the informativeness of ROTEM performed at the stage of cardiopulmonary bypass (CPB) before neutralization of heparin with protamine and to study the prognostic value of this study in assessing the risk of postoperative bleeding during cardiac surgery with a high risk of bleeding. Materials and methods. The assessment of the diagnostic significance of ROTEM studies at the CPB stage is based on the observation of 31 patients operated on from July to October 2018. The median age of these patients was 55 years (31–72 years). The criteria for inclusion of patients in the study were the performance of planned cardiac surgery with a high risk of bleeding: operations on the aorta, combined operations (coronary bypass surgery and/or surgery on the valve(s), multivalve correction), including repeated. Methods of descriptive statistics, correlation and comparative analyses, and ROC-analysis were used to assess the diagnostic and prognostic capabilities of ROTEM research during CPB against the back=-ground of high doses of heparin. Results. A statistically significant linear correlation was noted between A5 and MCF indicators in EXTEM, FIBTEM and PLTEM tests performed both during and after CPB. The results obtained indicate that determining the cause of bleeding and deciding on the choice of therapy is possible significantly earlier than the MCF indicator is determined, namely 5 minutes after the start of blood clotting in the ROTEM study. The informative value of ROTEM studies performed during CPB is shown, however, when interpreting the results, it is necessary to focus not only on the reference intervals, but also on the obtained cut-off levels for ROTEM parameters during CPB for early detection of hypofibrinogenemia or thrombocytopenia after CPB. Conclusion. ROTEM performed with the use of high doses of heparin during CPB is informative for the choice of pathogenetically justified therapy for possible bleeding.
The incidence of impaired binding capacity of von Willebrand factor to collagen types I and III in patients with type 1 von Willebrand disease
Authors: Koloskov A. V. , Vasileva M. Yu. , Philippova O. I. , Chernova E. V. , Beliaeva E. L. , Marchenko V. N. 
Published: May 2023

Introduction. Along with the quantitative characteristics of the von Willebrand factor (vWF), more attention is paid to its qualitative characteristics in patients with von Willebrand disease (vWD). Aim — to evaluate the frequency of vWF binding capacity disorders with type I collagen (vWF:CBAI) and type III collagen (vWF:CBAIII) in patients diagnosed with type 1 vWD and the diagnostic capabilities of these tests. Material and methods. The prospective study included 224 female patients with previously diagnosed vWD type 1. The following tests were performed in the venous blood sample: von Willebrand factor antigen (vWF:Ag), vWF:CBAI, vWF:CBAIII. The control group consisted of 80 healthy female blood donors. Results. In the control group, the values of vWF:CBAI and vWF:CBAIII did not exceed the reference intervals. A decrease in vWF:CBAI was detected in 133 (59.4 %) patients and vWF:CBAIII in 26 (11.6 %) patients. An isolated decrease in vWF:CBAI was detected in 87 (38.8 %) patients . An isolated decrease in vWF:CBAIII was less common — in 6 (2.7 %) patients. Conclusion. The study of vWF:CBAI and vWF:CBAIII appears to be useful as an additional diagnostic test to improve the distinction between healthy individuals and those with VWD.
Immunoglobulin genes and stereotyped antigenic receptors in chronic lymphocytic leukemia and other lymphoproliferative diseases
Authors: Biderman B. V. , Sudarikov A. B. 
Published: May 2023

Introduction. The mutational status of immunoglobulin heavy chain variable region genes (IGHV) is the most important prognostic factor in chronic lymphocytic leukemia (CLL). Furthermore, a significant narrowing of the IGHV gene repertoire is found in CLL and other lymphoproliferative diseases. Aim — to review the publication data on the IGHV genes repertoire and mutational status in CLL and other lymphoproliferative diseases regarding their clinical significance. General information. Nucleotide sequence of rearranged IGHV genes is a unique marker of a tumor clone. CLL patients with unmutated IGHV genes have an extremely unfavorable disease outcome in contrast to the patients with mutated IGHV genes. Patients with mutated IGHV genes benefit from conventional immunochemotherapy, while non-mutated IGHV patients require therapy escalation with new targeted drugs. The study of IGHV genes and stereotyped antigen receptors repertoire makes possible to identify additional groups of CLL patients with specific genetic and clinical features. Stereotype receptors are also detected in other lymphoproliferative diseases, but their clinical significance has not yet been defined. However, stereotyped receptors are found to be disease-specific.
Incidence and mortality rates of tumors of the hematopoietic and lymphoid tissues in a cohort of workers chronically exposed to ionizing radiation
Authors: Azizova T. V. , Bragin E. V. , Bannikova M. V. , Grigoryeva E. S. , Korobkin A. V. 
Published: May 2023

Introduction. Individuals acutely exposed to ionizing radiation demonstrated an increased risk of incidence of malignant neoplasms of the hematopoietic and lymphoid tissues (HLTT). Meanwhile papers describing the impact of chronic radiation exposure on the hematopoietic system are sparse.Aim — to assess incidence and mortality rates for HLTT in a cohort of workers exposed to chronic, occupational ionizing radiation. Materials and methods. Incidence and mortality rates of HLTT were assessed for workers of a nuclear industrial enterprise who had been hired at the facility from 1948–1982 and followed up until the end of 2018 (22,377 workers). All workers of the study cohort were externally and/or internally exposed to ionizing radiation during occupational industrial activities. In the studied cohort of workers, 186 cases and 123 deaths (as a main cause) from HLTT were registered throughout the entire follow-up period (1948–2018). Results. Crude incidence and mortality rates of HLTT in workers of the study cohort were associated with sex, attained age of workers and calendar follow-up period. Standardized incidence and mortality rates for males were significantly higher compared to females. The standardized HLTT incidence rates (per 1000 person-years of observation) were 0.36 ± 0.03 in males and 0.23 ± 0.04 in females while the standardized HLTT mortality rates were 0.16 ± 0.02 in males and 0.09 ± 0.02 in females. Conclusions. The study revealed significant increasing trends for incidence rates of chronic leukemia and lymphoma by the end of the follow-up period (31. 12. 2018).
Total knee arthroplasty in a female with a severe form of hemophilia A
Authors: Zorenko V. Yu. , Koroleva A. A. , Polyanskaya T. Yu. , Karpov E. E. , Pshenichnikova O. S. , Surin V. L. 
Published: May 2023

Introduction. Hemophilia is an X-linked hereditary blood clotting disorder caused by insufficiency of blood clotting factor VIII or IX that affects mainly men. In extremely rare cases, the disease can be observed in women, which is most often associated with asymmetric inactivation of the X chromosome. The severity of hemophilia in women does not differ from that in men. Aim – to present a clinical observation of surgical treatment of stage 4 hemophilic arthropathy in a woman with severe hemophilia A. Main findings. Female patient T., 39 years old, was admitted to the National Medical Research Center for Hematology with a preliminary diagnosis: hereditary deficiency of factor VIII. She had an extension of the APTT to 68.8 sec, a high level of Willebrand factor activity — 222 %, and the concentration of Willebrand factor antigen of 178.1 mg/l, and a decrease in the level of factor VIII to 1.6 %. According to molecular genetic analysis, intron 22 inversion associated with severe hemophilia A was detected in the F8 gene. Throughout the patient’s life, hemarthrosis of the knee, ankle and elbow joints were observed, which led to the development of severe arthropathy of varying severity. The woman underwent total knee arthroplasty and arthrolysis of the left ankle joint. The postoperative period proceeded without complications. Hemostatic replacement therapy was performed with a recombinant factor VIII.
Platelet Delta granules storage pool deficiency in female patient with severe hemorrhagic syndrome
Authors: Kosheed I. V. , Mamaev A. N. , Motin Y. G. , Kudinov A. V. , Momot A. P. , Babaeva T. N. 
Published: May 2023

Introduction. Platelet dense granule disorders are a group of rare heterogeneous disorders of the blood coagulation system in which bleeding occurs due to functional and morphological disorders of platelet organelles accumulating phosphates and bioactive amines. Aim — to present a clinical case of a 37-year-old patient with severe hemorrhagic syndrome. Basic information. An observation of the occurrence of hemorrhagic manifestations of unspecified genesis in a patient is described. The results of 25 healthy volunteer examinations of both sexes were used as a control for testing methods of diagnosis of Platelet dense granule disorder. Methods of assessing the hemostasis system, platelet morphological features using electron microscopy, as well as platelet accumulation of mepacrine using a flow cytometer were studied. Platelet dense granule disorder was detected by electron microscopy and confirmed by flow cytometry in a patient with severe hemorrhagic manifestations, in whom the diagnosis was not verified for a prolonged period of time.
ANALISIS PERBEDAAN VERBA DIALEK SIKKA NATAR DAN DIALEK TANA AI DALAM BAHASA SIKKA
Authors: Maria Olivia  , Maria E. D. Lering  , Rimasi  , Antonius M. K. Naro  
Published: May 2023

The purpose of this study aims at analysing the differences of verbs between the Sika and the Tana Ai dialects. This is a qualitative descriptive research to describe objectively and accurately. The subjects were 14 people of Sika Natar Hamlet in sika village and Pauklor Hamlet in Pruda village, 7 from each village respectively. The seven informants consist of 1 expert informant and 6 ordinary informants. Data were analyzed using the equivalent method. The results of data analysis based on the and interview and listening during the conversations between the researcher and the informants proved that there are pairs of different verbas with different phonemes in the initial, middle and final consonant sounds. Then, from the pair of consonants and vowels sounds, were also found.