bluuebunny/crossref_metadata_2025_split huggingface dataset:
Minimum data elements for the Australian Particle Therapy Clinical Quality Registry
Authors: Hwang Eunji , Gorayski Peter , Thwaites David , Le Hien , Skelton Kelly , Loong Jeffrey Tuan Kit , Langendijk Hans , Smith Ed , Yock Torunn I , Ahern Verity 
Published: July 2023

AbstractIntroductionConstruction of the first Australian particle therapy (PT) centre is underway. Establishment of a national registry, to be known as the Australian Particle Therapy Clinical Quality Registry (ASPIRE), has been identified as a mandatory requirement for PT treatment to be reimbursed by the Australian Medicare Benefits Schedule. This study aimed to determine a consensus set of Minimum Data Elements (MDEs) for ASPIRE.MethodsA modified Delphi and expert consensus process was completed. Stage 1 compiled currently operational English‐language international PT registries. Stage 2 listed the MDEs included in each of these four registries. Those included in three or four registries were automatically included as a potential MDE for ASPIRE. Stage 3 interrogated the remaining data items, and involved three rounds – an online survey to a panel of experts, followed by a live poll session of PT‐interested participants, and finally a virtual discussion forum of the original expert panel.ResultsOne hundred and twenty‐three different MDEs were identified across the four international registries. The multi‐staged Delphi and expert consensus process resulted in a total of 27 essential MDEs for ASPIRE; 14 patient factors, four tumour factors and nine treatment factors.ConclusionsThe MDEs provide the core mandatory data items for the national PT registry. Registry data collection for PT is paramount in the ongoing global effort to accumulate more robust clinical evidence regarding PT patient and tumour outcomes, quantifying the magnitude of clinical benefit and justifying the relatively higher costs of PT investment.
Diagnostic utility of allergy tests to predict baked egg and lightly cooked egg allergies compared to double‐blind placebo‐controlled food challenges
Authors: Krawiec Marta , Radulovic Suzana , Foong Ru‐Xin , Marques‐Mejias Andreina , Bartha Irene , Kwok Matthew , Jama Zainab , Harrison Faye , Ricci Cristian , Lack Gideon , Du Toit George , Santos Alexandra F. 
Published: July 2023

AbstractBackgroundDouble‐blind placebo‐controlled food challenges (DBPCFC) are the gold‐standard to diagnose food allergy. However, they can cause allergic reactions of unpredictable severity. We assessed accuracy of current and new diagnostic tests compared to DBPCFC to baked egg (BE) and to lightly cooked egg (LCE).MethodsChildren aged 6 months to 15 years were assessed for possible egg allergy as part of the BAT2 study (NCT03309488). They underwent clinical assessment, skin prick test (SPT), specific IgE (sIgE) and basophil activation test (BAT). The results of the tests were compared with DBPCFC outcomes to both BE and LCE.ResultsA total of 150 children underwent DBPCFC to BE, 60 (40%) reacted to and 85 (57%) tolerated BE and 5 (3%) had inconclusive oral food challenges (OFC). Seventy‐seven children tolerant to BE had DBPCFC to LCE and 16 reacted. The test within each modality with the best diagnostic performance for BE allergy was as follows: SPT to egg white (EW) (AUC = 0.726), sIgE to EW (AUC = 0.776) and BAT to egg (AUC = 0.783). BAT (AUC = 0.867) was the best test in the younger than 2 years age group. Applying 100% sensitivity and 100% specificity cut‐offs, followed by OFC, resulted in 100% diagnostic accuracy. BAT enabled the greatest reduction in OFC (41%). Using sIgE followed by BAT allowed to reduce the number of BATs performed by about 30% without significantly increasing the number of OFC.ConclusionsThe best diagnostic test was BAT to egg in terms of diagnostic accuracy and reduction in number of OFC. Using sIgE to EW followed by BAT required fewer BATs with sustained OFC reduction and diagnostic accuracy.
A 10‐year experience in testicular tissue cryopreservation for boys under 18 years of age: What can be learned from 350 cases?
Authors: Barraud‐Lange Virginie , Boissel Nicolas , Gille Anne‐Sophie , Jean Camille , Sitbon Leslie , Schubert Benoit , Yakouben Karima , Fahd Mony , Peycelon Matthieu , Paye‐Jaouen Annabel , Chalas Céline , Vanhaesebrouck Alexis , Doz François , Surun Aurore , Lemelle Lauriane , Sarnacki Sabine , Neven Bénédicte , Philippe‐Chomette Pascale , Dufour Christelle , Rigaud Charlotte , Leverger Guy , Tabone Marie‐Dominique , Irtan Sabine , Pondarée Corinne , Lezeau Harry , Lenaour Gilles , Sibony Mathilde , Comperat Eva , Brocheriou Isabelle , Wolf Jean Philippe , Dalle Jean‐Hugue , Poirot Catherine 
Published: July 2023

AbstractBackgroundA growing number of centers worldwide are preserving testicular tissue (TT) of young boys at risk of fertility loss to preserve their fertility. Data in this regard are scarce and experience sharing is essential to the optimization of the process.ObjectivesThis report of our 10‐year activity of pediatric fertility preservation (FP) has the objective to (1) improve knowledge regarding the feasibility, acceptability, safety, and potential usefulness of the procedure; (2) analyze the impact of chemotherapy on spermatogonia in the cryopreserved TT.Materials and methodsFor this retrospective study of data prospectively recorded, we included all boys under 18 years of age referred to the FP consultation of our academic network between October 2009 and December 2019. Characteristics of patients and cryopreservation of testicular tissue (CTT) were extracted from the clinical database. Univariate and multivariate analyses were used to assess factors associated with the risk of absence of spermatogonia in the TT.ResultsThree hundred and sixty‐nine patients (7.2 years; 0.5–17.0) were referred to the FP consultation for malignant (70%) or non‐malignant (30%) disease, of whom 88% were candidates for CTT, after a previous chemotherapy exposure (78%). The rate of recorded immediate adverse events was 3.5%, with painful episodes dominating. Spermatogonia were detected in the majority of TTs: 91.1% of those exposed to chemotherapy and 92.3% of those not exposed (p = 0.962). In multivariate analysis, the risk of absence of spermatogonia was almost three‐fold higher in boys > 10 years of age ([OR] 2.74, 95% CI 1.09–7.26, p = 0.035) and four‐fold higher in boys exposed to alkylating agents prior to CTT ([OR] 4.09, 95% CI 1.32–17.94, p = 0.028).Discussion/conclusionThis large series of pediatric FP shows that this procedure is well accepted, feasible, and safe in the short term, strengthening its place in the clinical care pathway of young patients requiring a highly gonadotoxic treatment. Our results demonstrate that CTT post‐chemotherapy does not impair the chance to preserve spermatogonia in the TT except when the treatment includes alkylating agents. More data on post‐CTT follow‐up are still required to ensure the long‐term safety and usefulness of the procedure.
Effects of foraging tunnels created by plateau zokors on plant above‐ground biomass and species richness of graminoids and forbs in alpine grasslands
Authors: Yang Huan , Duan Yuan‐Yuan , Li Jie , Wang Qian , Guo Zheng‐Gang 
Published: July 2023

AbstractQuestionForaging‐tunnel disturbances created by herbivorous mammals can influence the above‐ground plant biomass of grassland communities. The plateau zokor (Eospalax baileyi) was considered a focal animal for investigating the effect of foraging‐tunnel disturbances created by herbivorous mammals on the above‐ground biomass and species richness of graminoids and forbs. Here, we ask how foraging‐tunnel disturbances created by plateau zokors influences above‐ground plant biomass and species richness of graminoids and forbs in alpine grasslands.LocationThe study was conducted at three sites of alpine grasslands in the Qinghai‐Tibetan Plateau, China.MethodsIn this study, all vascular plants were divided into graminoids and forbs, and 30 paired quadrats were randomly selected from each site. In total, 90 tunnel quadrats and 90 non‐tunnel quadrats were surveyed and sampled.ResultsThis study showed that foraging‐tunnel disturbances decreased the plant species richness of the grassland community and forbs by 16.5% and 17.7% respectively, whereas the response of graminoid species richness to foraging‐tunnel disturbance was different among the three sites, in which foraging‐tunnel disturbance decreased the graminoid species richness at Maqu and Xiahe sites and had no impact on the graminoid species richness at Tianzhu site. Regarding forbs, some legumes identified in the non‐tunnel quadrats were not observed in the tunnel quadrats. The foraging‐tunnel disturbances resulted in an above‐ground plant biomass decrease of 21.9% in the grassland community, 27.3% in forbs, and 17.2% in graminoids respectively. The percentage of graminoids in the above‐ground plant biomass increased from 50.4% in non‐tunnel quadrats to 55.5% in tunnel quadrats, a relative increase of 10.1% from the initial percentage.ConclusionsThese results indicate that the foraging‐tunnel disturbances seemed to improve the forage availability for livestock in tunnel quadrats due to a higher relative proportion of graminoids in the grassland plant community, despite a decrease in graminoid biomass. However, the tunnels not only decreased the above‐ground plant biomass and species richness of forbs, but also might have a negative impact on soil nitrogen input because of the absence of some legumes. The findings of this study suggest that reseeding some legumes is an effective approach to maintaining plant diversity and soil fertility, which can compensate for the negative effect of foraging‐tunnel disturbance on alpine grasslands.
Personal values, consumer identities, and attitudes toward electric cars among Egyptian consumers
Authors: Yacout Omneya M. 
Published: July 2023

AbstractMarketing scholars have extensively examined the role of altruistic and ecological personal values and pro‐environmental identity in ethical consumption decisions. Conversely, the role of egoistic personal values and other identities has received scant attention from researchers. This research examines the role of altruistic, egoistic, and ecological personal values in triggering two types of identities: pro‐environmental and car‐authority. The effects of values and identities on personal norms and attitudes toward electric cars were also examined. A sample of Egyptian consumers responded to an electronic survey, and collected data were analyzed using SEM. The findings generally support the VIP framework, where biospheric values significantly affect pro‐environmental identity, and pro‐environmental identity affects personal norms. Furthermore, personal norms affected attitudes positively. A different path was obtained which starts with biospheric and altruistic values affecting car authority positively and negatively, respectively. Car authority identity was found to affect attitudes directly, although this is accepted at lower confidence levels. A discussion of research findings, implications, and research limitations were also presented.
The heterogeneous crustal architecture of the Falkland Plateau Basin
Authors: Stanca Roxana M. , Hodgson David M. , McCarthy Dave J. , Mortimer Estelle J. 
Published: July 2023

AbstractContinental break‐up can be oftentimes associated with intracontinental wrenching that can lead to the generation of transform margins and transform marginal plateaus. The wrenching phase can be accompanied by complicated processes, which result in heterogeneous structural and crustal architectures. This makes understanding the evolution of such tectonic settings challenging. The Falkland Plateau is an example of a transform marginal plateau where regional wrenching accompanied the incipient stages of Gondwanan continental break‐up to result in a mosaic of crustal types underlying its largest basin: the Falkland Plateau Basin (FPB). The uncertainties in crustal boundaries have led to several models for the evolution of the plateau, which hinder the development of a reliable plate reconstruction of Southern Gondwana. We integrate seismic reflection, gravity and magnetic data to propose an updated crustal architecture of the FPB. The results show that extended continental crust underlies the basin in the west and north. The eastern and central parts consist of a juxtaposition of intruded and underplated continental crust which transitions southwards to a thick oceanic domain. The basin is crosscut by three main NE–SW trending shear zones which facilitated the development of the contrasting crustal and structural domains interpreted across the plateau. This integrated reassessment of the FPB provides new insights into the tectonic evolution of the plateau, the deformation associated with wrenching and transform margin formation and our understanding of the tectono‐stratigraphic evolution of such areas.
Links between parent–child conversations about emotions and changes in children's emotion knowledge across early childhood
Authors: Reschke Peter J. , Clifford Brandon N. , Brown Mindy , Siufanua Matthew , Graver Haley , Cooper Alexandra M. , Porter Chris L. , Stockdale Laura A. , Coyne Sarah M. 
Published: July 2023

AbstractThis study examined different sources of emotion socialization. Children (N = 256, 115 girls, 129 boys, 12 child gender not reported) and parents (62% White, 9% Black, 19% Hispanic, 3% Asian American, and 7% “Other”) were recruited from Denver, Colorado. In waves 1 (Mage = 2.45 years, SD = 0.26) and 2 (Mage = 3.51 years, SD = 0.26), parents and children discussed wordless images of children experiencing an emotion (e.g., sad after dropping ice cream). Children's emotion knowledge was assessed at waves 2 and 3 (Mage = 4.48 years, SD = 0.26). Structural equation modeling found concurrent and prospective relations between parents' questions, parents' emotion talk, children's emotion talk, and children's emotion knowledge, highlighting the multidimensional nature of early emotion socialization.
Modeling Structure‐Building in the Brain With CCG Parsing and Large Language Models
Authors: Stanojević Miloš , Brennan Jonathan R. , Dunagan Donald , Steedman Mark , Hale John T. 
Published: July 2023

AbstractTo model behavioral and neural correlates of language comprehension in naturalistic environments, researchers have turned to broad‐coverage tools from natural‐language processing and machine learning. Where syntactic structure is explicitly modeled, prior work has relied predominantly on context‐free grammars (CFGs), yet such formalisms are not sufficiently expressive for human languages. Combinatory categorial grammars (CCGs) are sufficiently expressive directly compositional models of grammar with flexible constituency that affords incremental interpretation. In this work, we evaluate whether a more expressive CCG provides a better model than a CFG for human neural signals collected with functional magnetic resonance imaging (fMRI) while participants listen to an audiobook story. We further test between variants of CCG that differ in how they handle optional adjuncts. These evaluations are carried out against a baseline that includes estimates of next‐word predictability from a transformer neural network language model. Such a comparison reveals unique contributions of CCG structure‐building predominantly in the left posterior temporal lobe: CCG‐derived measures offer a superior fit to neural signals compared to those derived from a CFG. These effects are spatially distinct from bilateral superior temporal effects that are unique to predictability. Neural effects for structure‐building are thus separable from predictability during naturalistic listening, and those effects are best characterized by a grammar whose expressive power is motivated on independent linguistic grounds.
Incidence of atrial and ventricular arrhythmias in obese patients with heart failure with reduced ejection fraction treated with sacubitril/valsartan
Authors: Abumayyaleh Mohammad , Demmer Jonathan , Krack Carina , Pilsinger Christina , El‐Battrawy Ibrahim , Aweimer Assem , Lang Siegfried , Mügge Andreas , Akin Ibrahim 
Published: July 2023

AbstractAimTo compare clinical outcomes among patients with heart failure and reduced ejection fraction (HFrEF) according to body mass index (BMI) after initiating treatment with an angiotensin‐receptor neprilysin inhibitor (ARNI).MethodsWe gathered data from 2016 to 2020 at the University Medical Center Mannheim; 208 consecutive patients were divided into two groups according to BMI (< 30 kg/m2; n = 116, ≥ 30 kg/m2; n = 92). Clinical outcomes, including mortality rate, all‐cause hospitalizations and congestion, were systematically analysed.ResultsAt the 12‐month follow‐up, the mortality rate was similar in both groups (7.9% in BMI < 30 kg/m2 vs. 5.6% in BMI ≥ 30 kg/m2; P = .76). All‐cause hospitalization before ARNI treatment was comparable in both groups (63.8% in BMI < 30 kg/m2 vs. 57.6% in BMI ≥ 30 kg/m2; P = .69). After ARNI treatment, the hospitalization rate was also comparable in both groups at the 12‐month follow‐up (52.2% in BMI < 30 kg/m2 vs. 53.7% in BMI ≥ 30 kg/m2; P = .73). Obese patients experienced more congestion compared with non‐obese patients at follow‐up, without statistical significance (6.8% in BMI < 30 kg/m2 vs. 15.5% in BMI ≥ 30 kg/m2; P = .11). Median left ventricular ejection fraction (LVEF) improved in both groups, but significantly more in non‐obese compared with obese patients at the 12‐month follow‐up (from 26% [3%‐45%] [min.‐max.] vs. 29% [10%‐45%] [min.‐max.] [P = .56] to 35.5% [15%‐59%] [min.‐max.] vs. 30% [13%‐50%] [min.‐max.] [P = .03], respectively). The incidence of atrial fibrillation (AF), non‐sustained (ns) and sustained ventricular tachycardia (VT) and ventricular fibrillation (VF) was less in non‐obese than in obese patients after initiation of sacubitril/valsartan at the 12‐month follow‐up (AF: 43.5% vs. 53.7%; P = .20; nsVT: 9.8% vs. 28.4%; P = .01; VT: 14.1% vs. 17.9%; P = .52; VF: 7.6% vs. 13.4%; P = .23).ConclusionsThe incidence of congestion in obese patients was higher compared with non‐obese patients. LVEF improved significantly more in non‐obese compared with obese HFrEF patients. Furthermore, AF and the ventricular tachyarrhythmia rate were revealed more in obesity compared with those without obesity at the 12‐month follow‐up.
Proteomic profile of the acquired enamel pellicle of children with early childhood caries and caries‐free children
Authors: Oliveira Bethania Paludo , Buzalaf Marília Afonso Rabelo , Silva Natália Caldeira , Ventura Talita Mendes Oliveira , Toniolo Júlia , Rodrigues Jonas Almeida 
Published: July 2023

AbstractAcquired enamel pellicle plays an important role in the pathogenesis of early childhood caries (ECC), working as a protective interface between the tooth and the oral cavity. The aim of this cross‐sectional in vivo proteomic study was to compare the acquired enamel pellicle protein profile of 3–5‐year‐old children with ECC (n = 10) and caries‐free children (n = 10). Acquired enamel pellicle samples were collected and processed for proteomic analysis (nLC‐ESI‐MS/MS). In total, 241 proteins were identified. Basic salivary proline‐rich protein 1 and 2, Cystatin‐B, and SA were found only in the caries free group. When comparing caries free and ECC groups, lower protein levels were found in the caries free group for hemoglobin subunit beta, delta, epsilon, gamma‐2, globin domain‐containing protein and gamma‐1, neutrophil defensin 3, serum albumin, protein S100‐A8, and S100‐A9. The proteins histatin‐1, statherin, salivary acidic proline‐rich phosphoprotein ½, proline‐rich protein 4, submaxillary gland androgen‐regulated protein 3B, alpha‐amylase 1 and 2B were found at higher levels in the caries free group. The exclusive and the proteins found at higher levels in the caries free group might have protective functions that play a role in the prevention of caries, besides providing important insights to be evaluated in future studies for the possible development of new therapeutic strategies for ECC.
Effect of needle orientation during arteriovenous access puncture on needed compression time after hemodialysis: A randomized controlled trial
Authors: Loizeau Valérie , Tanouti Hanan , Marcheguet Audrie , Loubière Guillaume , Aegerter Philippe , Drioueche Hocine , Pembebjoglou Sandra 
Published: July 2023

AbstractBackgroundThere are two techniques for puncturing an arteriovenous fistula: one where the needle is inserted bevel up and then rotated to a bevel down position, and another where the needle is inserted bevel down. The aim of this study was to compare these two methods of needle insertion on minimum compression time required for hemostasis after needle removal.MethodsThis was a prospective, randomized, cross‐over, blinded, single‐center, routine care study. Each patient's average post‐dialysis puncture site compression time was determined during a 2‐week baseline period while using bevel‐up access puncture. Subsequently, minimum post‐dialysis puncture‐site compression time was determined during each of two sequential follow‐up periods, during which fistula puncture was done with needles inserted bevel up or down, respectively. The order of treatments (bevel up or bevel down insertion) was randomized. During each follow‐up period, the minimum compression time necessary to avoid bleeding on needle removal was determined by progressively shortening the compression time. Puncture‐associated pain was also assessed as prepump and venous pressures and ability to achieve desired blood flow rate during the dialysis session.ResultsForty‐two patients were recruited. The baseline compression time after needle removal averaged 9.99 ± 2.7 min During the intervention periods, the minimum compression time was on average 10.8 min (9.23–12.4) when the access needles had been inserted bevel down versus 11.1 min (9.61–12.5) when the access needles had been inserted bevel up (p = 0.72). There was no difference in puncture‐associated pain between the two insertion techniques, and no difference in prepump or venous pressures or ability to achieve the desired blood flow rate during the dialysis session.ConclusionBevel‐up and bevel‐down needle orientation during arteriovenous fistula puncture are equivalent techniques in terms of achieving hemostasis on needle removal, and puncture‐associated pain.
High‐temperature strength behavior of tantalum diboride to 2000°C
Authors: Vasylkiv Oleg , Demirskyi Dmytro 
Published: July 2023

AbstractThis study investigated the high‐temperature strength of spark plasma sintered tantalum diboride (TaB2) for the first time. TaB2 exhibited a unique elastic fracture behavior below 1900°C, unlike other transition metal diborides. The consolidation process involved spark plasma sintering at 2000–2200°C yielding dense TaB2 samples. The flexural strength was measured at elevated temperatures up to 2000°C, showing a quite high flexural strength of 400 ± 20 MPa at 1900°C. These findings provide valuable insights into the high‐temperature behavior of TaB2, highlighting its potential for advanced applications.