bluuebunny/crossref_metadata_2025_split huggingface dataset:
YOGA: METODE LATIHAN DAN PENYEMBUHAN HOLISTIK
Authors: Ni Wayan Sri Rahayu  , I Made Nuhari Anta  
Published: September 2023

Yoga could be defined as a spiritual science that is currently growing rapidly almost everywhere around the globe. This particular yoga practice, which combines traditional and modern techniques, is intended to enhance all three aspects of physical, mental, and spiritual health in the human body. Asana practice, pranayama exercises, and meditation are the three yoga practices through which these three components can be attained. The third part of Astangga Yoga (the eight stages of doing yoga) is the practice of Asanas or physical movements. Asanas are described as an upright pleasant position. By practicing asanas for 45 minutes in the morning or in the evening, either through Surya Namaskara Yoga movements or individual Asanas movements, one may stretch the muscles, joints, and nerves in the body. The second exercise namely Pranayama, or breathing methods of control; in this situation, proper and good breath control may promote calmness. Respiratory control could also affect an individual’s capacity for controlling their anxiety and handling too much stress. The current condition is able to be obtained due to the breath control that is capable to produce a favorable impact on neurotransmitters, the activity of alpha waves, and the activity of the vagal tone (neurological systems that control the heart, lungs, and gastrointestinal tract). This is therefore capable of producing tremendous usefulness for decreasing passion and providing a sense of calmness. Ability to induce a relaxation state despite undue exertion or pressure. Once the first two exercises are completed successfully, the third practice is meditation, which tries to connect the energy inside humans with the energy of the cosmos or may be viewed as the individual recognizing and comprehending who he/she actually is. Holistic health may be developed or established after these three elements have been attained through yoga practice.
Effect of 2-Arm Intervention on Emotional Outcomes in Informal Caregivers of Individuals With Multiple Sclerosis: A Randomized Pilot Study Trial
Authors: Douglas Sara L. , Plow Matthew , Packer Tanya , Lipson Amy R. , Lehman Michelle J. 
Published: September 2023

ABSTRACT

BACKGROUND
Caregivers of people with multiple sclerosis (MS) report poor emotional outcomes yet few interventions have been tested. The goal of this study was to compare the effectiveness of a remotely delivered intervention with 2 arms (ie, website and telecoaching vs website only) aimed at reducing depression, anxiety, stress, and distress in informal caregivers of individuals with MS.

METHODS
From March 2021 through August 2021, 151 care-givers were enrolled in the study. The intervention occurred over a 4-month period. The website plus telecoaching arm received (a) a monthly coaching session focused on information, skill building, and support that was delivered by a licensed social worker via videoconference or telephone, and (b) had access to a study-designed website for caregivers of individuals with MS. The website-only arm did not receive coaching sessions and had the same website access. Data were obtained at baseline, immediately after the intervention period, and 6 weeks after the intervention.

RESULTS
A linear mixed-effects model using an autoregressive covariance structure was used. It showed that the group by time interaction was statistically significant for the overall composite emotion score (depression, anxiety, stress) (P = .037) and the stress subscale score (P = .047), and it indicated that the website plus telecoaching arm demonstrated greater effectiveness at reducing the overall composite emotion and stress subscale scores.

CONCLUSIONS
Use of a remotely delivered psychoeducational intervention that included individual coaching sessions as well as website access demonstrated preliminary efficacy in improving emotional outcomes in caregivers of individuals with MS. Further testing of the intervention with a larger sample is recommended.
Assessment of selection criteria using multi-year study for effective breeding program of Zingiber officinale L
Authors: Begum Twahira , Gogoi Roktim , Gogoi Ankita , Gupta Tanmita , Chanda Sanjoy Kumar , Lekhak Himangshu , Lal Mohan 
Published: September 2023

Background
Ginger has been an important cash crop with numerous applications since ancient times. As the demand for ginger is ever-growing and being a seasonal crop, a high-yielding variety of ginger would be economically profitable.

Methods
In this study, 150 germplasm were collected from different regions of NE India and evaluated for three years in CRBD design with three replications. The present study thus focused on the variability, association, and diversity studies for the first time on 150 ginger germplasm from across North East India. The genotypic and phenotypic coefficient of variation, heritability, correlation, and path analysis were evaluated for the germplasm.

Results
Analysis of variance (ANOVA) revealed considerable differences among the studied germplasm for studied characters, revealing sufficient variability in the materials. The Mahalanobis D2 and Tocher methods grouped the 150 ginger germplasm into ten clusters. Based on the results of the path coefficient analysis determined for essential oil yield and rhizome yield per plant, it can be concluded that the characters’ initial rhizome weight, the weight of mother rhizome, and weight of secondary rhizome were the most important and appeared promising in improving the overall yield potential of ginger rhizome and essential oil yield. Thus, selection based on the identified traits would lead to an effective ginger breeding program for higher rhizome and essential oil yield.
The Implications of Growth-Regulating Substances on Growth and Yield Traits of Cauliflower
Authors: Gadhiya Dhara , Champaneri Dushyant D. , Patel Naren K. 
Published: September 2023

Background: Present investigation was carried out to evaluate the performance of the different levels of GA3 and NAA as foliar spray on growth and yield attributes of cauliflower cv. Pusa Snowball KT-25 at Vegetable Research Farm, Regional Horticultural Research Station, ASPEE College of Horticulture and Forestry, Navsari Agricultural University, Navsari, Gujarat.
Methods: The experiment was framed in Randomized Block Design with three replications, which included nine treatments.
Results: The results revealed that the application of GA3 @ 150 mg l-1 (T5) recorded higher values for growth character viz., plant height (69.26 cm), number of leaves plant-1 (29.67), length of stalk (6.54 cm) as well as plant spread in N-S (69.48 cm) and E-W (71.70 cm). In case of yield attributes, the same treatment GA3 @ 150 mg l-1 (T5) at 40 and 60 DATP exhibited maximum curd diameter (17.80 cm), gross weight of curd (2.88 kg plant-1), net weight of curd (789.59 g plant-1), yield plot-1 (20.23 kg) and yield hectare-1 (31.22 t) followed by NAA @ 80 mg l-1 (T7). Whereas, days to 50 % curd initiation and days to first marketable curd did not show any significant differences.
Rice Blast Forecasting Using Interval Valued Data at Coimbatore, India
Authors: Sandeep N. , Patil S. G. , Gopalakrishnan C. , Vijayabhama M. , Dheebakaran Ga. , A. G. Meena 
Published: September 2023

Aims: The persistence of rice blast, caused by the fungus Magnaporthe oryzae, continues to pose a significant threat to rice production worldwide, impacting both yields and food security. The primary goal of this study is to apply interval-valued independent weather data to accurately model the dependent variable of percentage disease incidence.
Study Design: In this paper, we present a detailed study on forecasting rice blast outbreaks through the application of Average method, Center method and Min Max method using interval valued weather data and percentage disease incidence.
Place and Duration of Study: The blast disease data include percent disease incidence (PDI) collected at the Paddy Breeding Station (PBS), Tamil Nadu Agricultural University, Coimbatore, from 2018 to 2021.And Weather variables includes the following: Maximum Temperature, Minimum Temperature, Relative humidity (morning), Relative humidity (evening) from 2018 to 2021.
Methodology: The available interval weather parameter data and disease incidence data are utilized to fit a regression model, specifically employing simple linear regression and multiple linear regression, in the R version 4.3.0.
Results: Upon analyzing various methods, it is evident that the variables of Minimum temperature exhibit a significant relationship with a high level of significance, indicating a significance level at
P 0.001.
Conclusion: Minimum temperature shows more contribution in disease incidence followed by relative humidity at evening.
Effect of Bio-enhancers and Bio-Fertilizers on Growth and Quality of Mango cv. Amrapali under Sub-tropical Plains of Central Uttar Pradesh, India
Authors: Bhadauria Ankit Singh , Tripathi V. K. 
Published: September 2023

A Field experiment was conducted in the Garden of Department of Horticulture, Chandra Shekhar Azad University of Agriculture and Technology, Kanpur (U.P.) during 2020-2021. The experiment was laid out in randomized block design with seven treatments i.e., FYM (25 kg/tree/year) + Organic mulch (Paddy straw) i.e., Control, FYM (25 kg/tree/year) + Organic mulch (Paddy straw) + Amritpani (20%) + Azotobacter (100g/tree), FYM (25 kg/tree/year) + Organic mulch (Paddy straw) + Panchagavya (3%) + Azotobacter (100g/tree), FYM (25 kg/tree/year) + Organic mulch (Paddy straw) + Jivamrit (20%) + Azotobacter (100g/tree), FYM (25 kg/tree/year) + Organic mulch (Paddy straw) + Amritpani (20%) + PSB culture (100g/tree), FYM (25 kg/tree/year) + Organic mulch (Paddy straw) + Panchagavya (3%) + PSB culture (100g/tree), FYM (25 kg/tree/year) + Organic mulch (Paddy straw) + Jivamrit (20%) + PSB culture (100g/tree) which were replicated thrice using one plant as a unit per treatment. The mango cultivar “Amrapali” was treated with different organic materials like farm yard manure, organic mulch (Paddy straw), Azotobacter, PSB culture, Panchagavya (3%), Jivamrit (20%) and Amritpani (20%) respectively and compared with the control.
The experimental results revealed that plants treated with the application of FYM (25 kg/tree/year) + Organic mulch (Paddy straw) + Panchagavya (3%) + Azotobacter (100g/tree) recorded a significantly higher number of leaves per shoot, number of inflorescence per branch, maximum TSS, total sugar content, sugar: acid ratio and is at par with application of FYM (25 kg/tree/year) + Organic mulch (Paddy straw) + Panchagavya (3%) + PSB culture (100g/tree) (14.67) and FYM (25 kg/tree/year) + Organic mulch (Paddy straw) + Jivamrit (20%) + Azotobacter (100g/tree). Thus, on the basis of the above observations, this can be suggested that for getting substantially more vegetative growth and quality fruits, the application of FYM (25 kg/tree/year) + Organic mulch (Paddy straw) + Panchagavya (3%) + Azotobacter (100g/tree) should be made under the sub-tropical plains of Central Uttar Pradesh, India.
Relationship of Maternal Serum Zinc Level with Preeclampsia
Authors: Parvin Maliha , Laila Tarafdar Runa , Ahmed Sheikh Salahuddin , Shamsunnahar Parveen Akhter , Khatun Khodeza , Sultana Nigar , Nahar Munmun , Yasmin Sumaiya 
Published: September 2023

Preeclampsia is an important cause of maternal and perinatal morbidities. Zinc is an essential trace element that is presumed to have a role in the regulation of blood pressure through its antioxidant properties and modulation of renal sodium transport. The objective of the study was to determine the relationship between maternal serum zinc level and preeclampsia. This case-control study was conducted among 100 pregnant women at the Department of Obstetrics and Gynecology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh. Among the 100 patients, 50 were pregnant women with preeclampsia (cases) and 50 were pregnant women without preeclampsia (controls). The serum zinc level was measured for all of them. The mean serum zinc level of the cases and controls were 59.58±31.79 μg/dl and 89.02±31.14 μg/dl respectively (P=<0.001). The respondents with zinc level <68 μg/dl had 6.05 times more chances to have preeclampsia compared to that of the respondents with zinc level ≥68 μg/dL (p<0.001; OR=6.048; 95% CI=2.540-14.399). There was significant negative correlation of serum zinc level with both systolic blood pressure (r= -0.340, p=0.001) and diastolic blood pressure (r=-0.404, p<0.001). In conclusion, low maternal serum zinc level was found related to preeclampsia.
Compound Motion‐Mode Tribovoltaic Nanogenerator for Self‐Powered Monitoring of Gear Transmission System
Authors: Wang Song , Gong Likun , Jiang Yuhang , Gao Shuai , Wang Tianyang , Zhang Chi , Han Qinkai 
Published: January 2025

AbstractTribovoltaic nanogenerators (TVNGs) are an advanced technology that can convert friction energy into electrical energy via semiconductor tribovoltaic effect, which offers the advantages of high charge density and direct current (DC) output. However, characteristic components of TVNG outputs are relatively few, which is not conducive to monitoring the periodic motions. This study proposes a compound motion‐mode tribovoltaic nanogenerator (CM‐TVNG) for monitoring the gear transmission system using gears' unique meshing transmission form. The CM‐TVNG uses the approach‐slide‐separation composite motion of silicon wafers attached to both sides of the tooth slots and the tooth top of the mating gear to generate a DC signal with discernible periodic characteristics. The working principle of CM‐TVNG is verified by theoretical analysis and COMSOL dynamic simulation. The main working parameters verify CM‐TVNG output characteristics and applicability under various conditions. Subsequently, CM‐TVNG's ability to detect gear's state is verified. Using a deep learning (DL) model, gear faults are diagnosed with a diagnostic accuracy of up to 95.5%. The feasibility of CM‐TVNG is demonstrated by application in an industrial‐grade parallel‐gear transmission system. In particular, speed monitoring capability under variable speeds is verified, demonstrating that it can be applied to monitor the stability of gear transmission systems.
The Histone Lysine Demethylase KDM7A Contributes to Reward Memory via Fscn1‐Induced Synaptic Plasticity in the Medial Prefrontal Cortex
Authors: Yang Zhuo‐jin , Yu Dong‐yu , Gao Fei‐fei , Zhou Dan‐ya , Wu Ya‐nan , Yang Xi‐xi , Chen Jie , Yang Jing‐si , Shen Meng‐qing , Zhang Yu‐xiang , Wei Lai , Yan Chun‐xia 
Published: January 2025

AbstractLysine demethylase 7A (KDM7A) catalyzes the removal of dimethylation from histone H3 lysine 9 and lysine 27, both of which are associated with transcription repression. Previous study indicates that Kdm7a mRNA in the medial prefrontal cortex (mPFC) increases after drug exposure, yet its role in drug‐related behaviors is largely unknown. In a morphine‐conditioned place preference (CPP) paradigm, these findings reveal a specific increase of Kdm7a expression in the mPFC 7 days after drug withdrawal. Subsequently, these results demonstrate that knockdown of Kdm7a in the mPFC do not affect the acquisition of morphine‐induced CPP, but it attenuate memory consolidation. To further explore Kdm7a‐mediated transcriptomic changes, this work employs Nanopore direct RNA sequencing. Transcriptome profiling unveils several gene expression alterations impacted by KDM7A, which are enriched in relevant neural function categories. Notably, this work identifies and validates fascin actin‐bundling protein 1 (Fscn1) as a downstream molecular target. Knockdown of Fscn1 has a similar impact on CPP to Kdm7a, along with corresponding decrease of dendritic spine density and neuronal activity in the mPFC. Additionally, silencing Kdm7a decreases enrichment of H3K9me2 and H3K27me2 at the Fscn1 promoter region, suggesting that KDM7A may act as a crucial regulator of transcriptional responses to morphine‐related reward memory via Fscn1.
Extracellular Mitochondrial‐Derived Vesicles Affect the Progression of Diabetic Foot Ulcer by Regulating Oxidative Stress and Mitochondrial Dysfunction
Authors: Zhang Huihui , Yan Zi , Zhu Junyou , Li Ziyue , Chen Lianglong , Zheng Weihan , Dai Zhenning , Yang Jiaxin , Yun Xinyi , Wang Yilin , Zhou Hai , Jiang Ziwei , Yu Qiuyi , Li Shiyu , Huang Wenhua , Yang Lei 
Published: January 2025

AbstractDiabetic foot ulcer (DFU) is a common and severe complication of diabetes mellitus, the etiology of which remains insufficiently understood, particularly regarding the involvement of extracellular vesicles (EVs). In this study, nanoflow cytometry to detect EVs in DFU skin tissues is used and found a significant increase in the Translocase of Outer Mitochondrial Membrane 20 (TOM20)+ mitochondrial‐derived vesicles (MDVs). The role of MDVs in DFU is yet to be reported. Using single‐cell datasets, it is discovered that the increase in MDVs may be regulated by Sorting Nexin 9 (SNX9). In vitro experiments revealed that MDVs secreted by fibroblasts cultured in high glucose medium exhibited similar composition and protein enrichment results to those in DFU tissues, suggesting their potential as an ideal in vitro surrogate. These MDVs promoted apoptosis and intracellular oxidative stress, disrupted mitochondrial structure, and reduced aerobic metabolism in target cells. In vivo experiments also showed that MDV drops hindered wound healing in diabetic mice; however, this effect is rescued by SNX9 inhibitors, restoring mitochondrial dynamics and balance. Under high glucose conditions, MDVs significantly upregulated oxidative stress levels and induced mitochondrial dysfunction. This study proposes targeting MDVs as a potential therapeutic strategy for DFU.
High‐Efficiency, Long‐Lifetime and Color‐Tunable Hybrid WOLEDs Using a Platinum Complex with Voltage‐Dependent Monomer and Aggregate Emission
Authors: Xin Yangyang , Mao Mao , Xu Shuo , Tan Kaixin , Cheng Gang , Zhang Hai , Dai Hengyi , Huang Tianyu , Zhang Dongdong , Duan Lian , Che Chi‐Ming 
Published: January 2025

AbstractColor‐tunable white organic light‐emitting diodes (CT‐WOLEDs) have attracted widespread attention given their large color variation to meet the different daily scenarios from the perspective of circadian rhythm. However, most reported CT‐WOLEDs, especially the tri‐color devices, exhibit poor performances and sophisticated structures. Here, a simple structure tri‐color CT‐WOLED is demonstrated that simultaneously exhibits high efficiency, ultralong operation lifetime, and wide color‐tunable range for dynamic sunlight emulation. The design is based on a newly developed platinum complex that can emit light efficiently in both monomer and aggregation states, providing voltage‐dependent green‐to‐red phosphorescence emission, not only ensuring tunable colors in WOLEDs but also simplifying the device structure. Combining with a blue delayed fluorescence material, this hybrid device exhibits a wide range of tunable colors with Commission Internationale de l’Eclairage 1931 (CIE) coordinates and correlated color emperature (CCT) shifts from (0.502, 0.474) and 2628 K at 2.6 V to (0.211, 0.334) and 14860 K at 8 V, achieving good visual alignment with sunlight color throughout the day. This same device also shows high external quantum efficiencies from 28.8% at maximum to 26.2% at 5000 cd m−2. Furthermore, an impressively long time of 21,144 h is achieved to decay to 90% of the initial luminance at 100 cd m−2, being the longest among recorded CT‐WOLEDs.
Intestine‐Decipher Engineered Capsules Protect Against Sepsis‐induced Intestinal Injury via Broad‐spectrum Anti‐inflammation and Parthanatos Inhibition
Authors: Yan Yan , Li Bin , Gao Qiuxia , Wu Miao , Ma Hua , Bai Jiawei , Ma Chengtai , Xie Xinyu , Gong Yuan , Xu Lingqi , Li Xiaoxue , Wang Wei , Wu Yanqiu , Wang Jiamei , Wang Huanhuan , Feng Yi , Zhang Yunlong , Li Peiran , Shi Huimin , Ma Fei , Jia Yue , Duan Han , Fu Xinting , Wang Wenying , Zhan Liying , Du Xianjin , Zhou Huiting , Liao Yuhui 
Published: January 2025

AbstractSepsis is a severe systemic inflammatory syndrome characterized by a dysregulated immune response to infection, often leading to high mortality rates. The intestine, owing to its distinct structure and physiological environment, plays a pivotal role in the pathophysiology of sepsis. It functions as the “central organ” or “engine” in the progression of sepsis, with intestinal injury exacerbating the condition. Despite the availability of current therapies that offer partial symptom relief, they fall short of adequately protecting the intestinal barrier. In this study, an advanced nanodrug formulation (OLA@MΦ NPs) is developed by coating macrophage membranes onto polymeric organic nanoparticles encapsulating olaparib. When loaded into pH‐responsive capsules, an intestine‐decipher engineered capsule (cp‐OLA@MΦ NPs) is successfully formulated. Upon oral administration in septic mice, these capsules withstand gastric acid and release their contents in the intestine, specifically targeting injured tissues. The released OLA@MΦ NPs effectively neutralize pro‐inflammatory cytokines via macrophage membrane receptors, while olaparib inhibits intestinal epithelial parthanatos (a form of programmed cell death) by suppressing poly(ADP‐ribose) polymerase 1 (PARP1) activation. This strategy significantly reduces bacterial translocation, slows the progression of sepsis, and enhances survival in septic mice, thus presenting a promising therapeutic approach for sepsis in clinical applications.
Disturbing Cholesterol/Sphingolipid Metabolism by Squalene Epoxidase Arises Crizotinib Hepatotoxicity
Authors: Yan Hao , Huang Xiangliang , Zhou Yourong , Mu Yuan , Zhang Shaoyin , Cao Yashi , Wu Wentong , Xu Zhifei , Chen Xueqin , Zhang Xiaochen , Wang Xiaohong , Yang Xiaochun , Yang Bo , He Qiaojun , Luo Peihua 
Published: January 2025

AbstractMetabolic disorders have been identified as one of the causes of drug‐induced liver injury; however, the direct regulatory mechanism regarding this disorder has not yet been clarified. In this study, a single regulatory mechanism of small molecule kinase inhibitors, with crizotinib as the representative drug is elucidated. First, it is discovered that crizotinib induced aberrant lipid metabolism and apoptosis in the liver. A mechanistic study revealed that crizotinib treatment promoted the accumulation of squalene epoxidase (SQLE) by inhibiting autophagosome‐lysosome fusion which blocked the autophagic degradation of SQLE. A maladaptive increase in SQLE led to disturbances in cholesterol and sphingolipid metabolism via an enzymatic activity‐dependent manner. Abnormal cholesterol results in both steatosis and inflammatory infiltration, and disturbances in sphingolipid metabolism promote cell apoptosis by inducing lysosomal membrane permeabilization. The restoration of the level or activity of SQLE ameliorated steatosis and hepatocyte injury. The autophagy activator known as metformin or the SQLE enzymatic inhibitor known as terbinafine has potential clinical use for alleviating crizotinib hepatotoxicity.
Iodine‐Catalyzed Aerobic Oxidative Domino Cyclization of Methyl N‐Heteroarenes with 6‐Aminopyrimidine‐2,4‐Dione and Pyrazol‐5‐Amine
Authors: Dong Chunping , Zhang Yue , Hu Caijuan , Zhou Yongsheng , Li Jian 
Published: January 2025

AbstractAn iodine‐catalyzed aerobic oxidative domino annulation of methyl N‐heteroarenes with 6‐aminopyrimidine‐2,4‐dione and pyrazol‐5‐amine has been developed for the synthesis of dipyrimidine/dipyrazolo‐fused pyridines using 1,3‐dibromobenzene as the additive and oxygen as the terminal oxidant. Detailed mechanistic studies indicated that 1,3‐dibromobenzene enhanced the solubility of O2, and facilitated the aerobic oxidation of I− to I2, thereby promoting the aerobic oxidative domino cyclization reaction. The gram scale reaction was also successful using this methodology.