bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development and validation of an integrative pan-solid tumor predictor of PD-1/PD-L1 blockade benefit
Authors: Tomlins Scott A. , Khazanov Nickolay A. , Bulen Benjamin J. , Hovelson Daniel H. , Shreve Melissa J. , Lamb Laura E. , Matrana Marc R. , Burkard Mark E. , Yang Eddy Shih-Hsin , Edenfield William Jeffery , Dees E. Claire , Onitilo Adedayo A. , Thompson Michael , Buchschacher Gary L. , Miller Alan M. , Menter Alexander , Parsons Benjamin , Wassenaar Timothy , Hwang Leon C. , Suga J. Marie , Siegel Robert , Irvin William , Nair Suresh , Slim Jennifer N. , Misleh Jamal , Khatri Jamil , Masters Gregory , Thomas Sachdev , Safa Malek , Anderson Daniel M. , Kwiatkowski Kat , Mitchell Khalis , Hu-Seliger Tina , Drewery Stephanie , Fischer Andrew , Plouffe Komal , Czuprenski Eric , Hipp Jennifer , Reeder Travis , Vakil Hana , Johnson D. Bryan , Rhodes Daniel R. 
Published: February 2023

Abstract
Background
Anti-PD-1 and PD-L1 (collectively PD-[L]1) therapies are approved for many advanced solid tumors. Biomarkers beyond PD-L1 immunohistochemistry, microsatellite instability, and tumor mutation burden (TMB) may improve benefit prediction.

Methods
Using treatment data and genomic and transcriptomic tumor tissue profiling from an observational trial (NCT03061305), we developed Immunotherapy Response Score (IRS), a pan-tumor predictive model of PD-(L)1 benefit. IRS real-world progression free survival (rwPFS) and overall survival (OS) prediction was validated in an independent cohort of trial patients.

Results
Here, by Cox modeling, we develop IRS—which combines TMB with CD274, PDCD1, ADAM12 and TOP2A quantitative expression—to predict pembrolizumab rwPFS (648 patients; 26 tumor types; IRS-High or -Low groups). In the 248 patient validation cohort (248 patients; 24 tumor types; non-pembrolizumab PD-[L]1 monotherapy treatment), median rwPFS and OS are significantly longer in IRS-High vs. IRS-Low patients (rwPFS adjusted hazard ratio [aHR] 0.52, p = 0.003; OS aHR 0.49, p = 0.005); TMB alone does not significantly predict PD-(L)1 rwPFS nor OS. In 146 patients treated with systemic therapy prior to pembrolizumab monotherapy, pembrolizumab rwPFS is only significantly longer than immediately preceding therapy rwPFS in IRS-High patients (interaction test p = 0.001). In propensity matched lung cancer patients treated with first-line pembrolizumab monotherapy or pembrolizumab+chemotherapy, monotherapy rwPFS is significantly shorter in IRS-Low patients, but is not significantly different in IRS-High patients. Across 24,463 molecularly-evaluable trial patients, 7.6% of patients outside of monotherapy PD-(L)1 approved tumor types are IRS-High/TMB-Low.

Conclusions
The validated, predictive, pan-tumor IRS model can expand PD-(L)1 monotherapy benefit outside currently approved indications.
Aging-Related Decline in Phonated and Whispered Speech Perception Not Compensated For by Increased Duration and Intensity: Evidence From Mandarin-Speaking Adult Listeners
Authors: Xu Min , Shao Jing , Liu Boquan , Wang Lan , Ding Hongwei , Zhang Yang 
Published: February 2023

Purpose:
This study aimed to examine how aging and modifications of critical acoustic parameters may affect the perception of whispered speech as a degraded signal.

Method:
Forty Mandarin-speaking adults were included in the study. Part 1 of the study compared the perception of Mandarin lexical tones, vowels, and syllables in older and younger adults in whispered versus phonated speech conditions. Parts 2 and 3 further examined how modification of duration and intensity cues contributed to the perceptual outcomes.

Results:
Perception of whispered tones was compromised in older and younger adults. Older adults identified lexical tones less accurately than their younger counterparts, particularly for phonated T2 and T3 and whispered T3. Aging also negatively affected the vowel identification of /i, u/ in the whispered condition. Syllable-level accuracy was largely dependent on the accuracy of lexical tones and vowels. Furthermore, reduced duration led to the decreased accuracy of phonated T3 and whispered T2 and T3 but increased accuracy of phonated T4. Reduced intensity lowered the recognition accuracy for phonated vowels /i, ɤ, o, y/ in older adults and /i, u/ in younger adults, and it also lowered the accuracy of whispered vowels /a, ɤ/ in older adults. Contrary to our expectation, increased duration and intensity did not improve older adults' speech perception in either phonated or whispered conditions.

Conclusions:
The results suggest that aging adversely affected speech perception in both phonated and whispered conditions with more challenges in identifying whispered speech for older adults. While older adults' diminished performance may be potentially due to problems with processing the degraded temporal and spectral information of the target speech sounds, it cannot be simply compensated for by increasing the duration and intensity of the target sounds beyond the audible level.
Research on transformer fault diagnosis based on ISOMAP and IChOA‐LSSVM
Authors: Lu Wanjie , Shi Chun , Fu Hua , Xu Yaosong 
Published: February 2023

AbstractOil‐immersed transformers play an important role in the stable operation of power systems. In order to improve the accuracy of transformer fault diagnosis, a transformer fault diagnosis method based on Isomap and IChOA‐LSSVM is proposed. Firstly, Isomap is used to reduce the dimensionality of the 14‐dimensional transformer fault characteristics data to eliminate redundant data between variables. In addition, IChOA is proposed to optimise the Least Squares Support Vector Machine (LSSVM) parameters and establish an optimal diagnosis model based on LSSVM. For ChOA, three improvement methods are proposed. Circle mapping is used instead of the original population initialisation to improve population diversity. In addition, the location weighting strategy with proportional weights and the Gaussian Corsi variation strategy is proposed to improve the optimization accuracy and efficiency of ChOA. The improved ChOA is compared with the original ChOA, PSO and GWO algorithms by five benchmark test functions. Finally, the improved Chimpanzee Optimisation algorithm was used to find the parameters of the LSSVM to obtain the fault diagnosis model combining Isomap and IChOA‐LSSVM. The model is compared with PSO‐LSSVM, ChOA‐LSSVM and GWO‐LSSVM. The diagnostic accuracy is 90.83%, 81.67%, 83.33% and 80%, respectively. The results demonstrate that the proposed method can effectively improve the performance of transformer fault diagnosis.
Complete Resolution of Nonimmune Hydrops Fetalis Secondary to Maternal Syphilis Infection
Authors: Dinicu Andreea , Penalosa Patrick , Crosland Brian A. , Steller Jonathan 
Published: February 2023

AbstractMaternal syphilis infection is a common infectious cause of nonimmune hydrops fetalis. Generally, hydrops fetalis is equated with poor prognoses in affected pregnancies. A 38-year-old G5P2114 presented at 285/7 weeks' gestation with newly diagnosed primary syphilis infection, sonographic findings of hydrops fetalis, and elevated middle cerebral artery Dopplers concerning for fetal anemia. Following treatment with intramuscular penicillin, the symptoms of hydrops fetalis were resolved and our patient delivered a healthy male neonate with no signs of congenital syphilis at the time of delivery. Routine and early testing for syphilis is an important component of prenatal care. Though not previously documented, the secondary findings of suspected fetal syphilis may be able to completely resolve in utero with penicillin treatment.
Dehydroxylative Cyanation of Alcohols Promoted by Triphenyphosphine/1,2-Diiodoethane
Authors: Lin Jin-Hong , Xiao Ji-Chang , Luo Ling 
Published: February 2023

AbstractA Ph3P/ICH2CH2I-promoted dehydroxylative cyanation of alcohols has been developed. In contrast to previous dehydroxylative cyanation methods that can suffer from several limitations, such as the use of transition metals or moisture-sensitive Lewis acids, this protocol features convenient operations, mild reaction conditions, and the use of cheap and widely available reagents.
Manganese-Mediated Aerobic Oxidative Denitroalkylation of β-Nitrostyrenes with Alkylboronic Acids
Authors: Guo Sheng-rong , Yu Zi-yuan , Hu Jing-jiang , Yu Ya-xuan , Yuan Yan-qin 
Published: February 2023

AbstractAn aerobic oxidative stereoselective denitroalkylation of β-nitrostyrenes under mild conditions by using an alkylboronic acid as the alkyl source was achieved. This protocol accepts a broad scope of β-nitrostyrenes and alkylboronic acids, leading to the formation of C(sp3)–C(sp2) bonds. Air was employed to reoxidize the resultant Mn(II) species back to Mn(III) during the catalytic cycle.
Heterotopic Ossification in Hip Arthroscopy
Authors: Seijas Roberto , Barastegui David , Celis Carlos López de , Montaña Ferran , Cuscó Xavier , Cugat Ramón 
Published: February 2023

Abstract
Introduction Hip arthroscopy is a rising surgical technique due to the increase in hip diseases, especially femoroacetabular impingement. One of the several complications related to such procedures is heterotopic ossifications (HO). The aim of this study is to describe the prevalence of HO after hip arthroscopy in a series of patients with femoroacetabular impingement and to compare its preoperative and intraoperative variables with a matched control group of patients without HO.
Methods All patients who underwent hip arthroscopy for femoroacetabular impingement between 2010 and 2017 with a minimum follow-up of 2 years were included in this analysis. Radiographic examinations were recorded to select cases with HO. A case-control analysis was performed comparing preoperative and intraoperative variables between cases with HO and a matched control group without HO.
Results A total of 700 cases were included in the analysis. HO was found in 15 (2.14%) of subjects. Cases with HO showed more severe cartilage injuries, less cam morphology ratio, and a higher proportion of partial labrectomies than the control group. No significant differences were observed in preoperative hip pain or function between groups.
Conclusions The prevalence of HO after hip arthroscopy in subjects with femoroacetabular impingement was 2.14%. Cases with HO had more severe cartilage injuries, lower ratio of cam morphology, and higher proportion of partial labrectomies than the control cases without HO.
Level of Evidence Level III.
Challenges with Adjuvant Radiation for Intracranial Chondrosarcoma in Pregnancy
Authors: Yadav Arun , Goyal Shikha , Madan Renu , Singh Ranjit , Chitkara Aarti , Khosla Divya 
Published: February 2023

Background
Managing a brain tumor during pregnancy is a highly confusing and challenging situation, complicated by several technical, medical, ethical, and sociocultural concerns. The interests of the mother and child are often pitted against each other, for which legal opinion may occasionally be needed.

Case Report
We present the report of a young lady with intracranial well-differentiated chondrosarcoma who was determined to be pregnant in the immediate postoperative period. We discuss the management of challenges and dilemmas in devising optimum therapy, and the modifications and care required at each step to help safeguard maternal and fetal health. Risks with therapeutic radiation and measures to assess and pre-empt fetal doses that may assist decision-making are also discussed.

Conclusion
Radiation therapy during pregnancy is challenging and requires multidisciplinary involvement and psychosocial support for the patient and family.
Comparative study of first-principles approaches for effective Coulomb interaction strength Ueff between localized f-electrons: Lanthanide metals as an example
Authors: Liu Bei-Lei , Wang Yue-Chao , Liu Yu , Xu Yuan-Ji , Chen Xin , Song Hong-Zhou , Bi Yan , Liu Hai-Feng , Song Hai-Feng 
Published: February 2023

As correlation strength has a key influence on the simulation of strongly correlated materials, many approaches have been proposed to obtain the parameter using first-principles calculations. However, a comparison of the different Coulomb strengths obtained using these approaches and an investigation of the mechanisms behind them are still needed. Taking lanthanide metals as an example, we research the factors that affect the effective Coulomb interaction strength, Ueff, by local screened Coulomb correction (LSCC), linear response (LR), and constrained random-phase approximation (cRPA) in the Vienna Ab initio Simulation Package. The UeffLSCC value increases from 4.75 to 7.78 eV, UeffLR is almost stable at about 6.0 eV (except for Eu, Er, and Yb), and UeffcRPA shows a two-stage decreasing trend in both light and heavy lanthanides. To investigate these differences, we establish a scheme to analyze the coexistence and competition between the orbital localization and the screening effect. We find that LSCC and cRPA are dominated by the orbital localization and the screening effect, respectively, whereas LR shows the balance of the competition between the two factors. Additionally, the performance of these approaches is influenced by different starting points from the Perdew–Burke–Ernzerhof (PBE) and PBE + U, especially for cRPA. Our results provide useful knowledge for understanding the Ueff of lanthanide materials, and similar analyses can also be used in the research of other correlation strength simulation approaches.
A small-molecule drug inhibits autophagy gene expression through the central regulator TFEB
Authors: Lin Yuqi , Shi Qiqi , Yang Guang , Shi Fuchun , Zhou Yang , Wang Tongtong , Xu Peng , Li Peifeng , Liu Zaizhou , Sun Hanyin , Zhao Zhixin , Ding Ke , Wang Zhen , Feng Haizhong , Yu Biao , Fang Pengfei , Wang Jing 
Published: February 2023

Autophagy supports the fast growth of established tumors and promotes tumor resistance to multiple treatments. Inhibition of autophagy is a promising strategy for tumor therapy. However, effective autophagy inhibitors suitable for clinical use are currently lacking. There is a high demand for identifying novel autophagy drug targets and potent inhibitors with drug-like properties. The transcription factor EB (TFEB) is the central transcriptional regulator of autophagy, which promotes lysosomal biogenesis and functions and systematically up-regulates autophagy. Despite extensive evidence that TFEB is a promising target for autophagy inhibition, no small molecular TFEB inhibitors were reported. Here, we show that an United States Food and Drug Administration (FDA)-approved drug Eltrombopag (EO) binds to the basic helix-loop-helix-leucine zipper domain of TFEB, specifically the bottom surface of helix-loop-helix to clash with DNA recognition, and disrupts TFEB-DNA interaction in vitro and in cellular context. EO selectively inhibits TFEB’s transcriptional activity at the genomic scale according to RNA sequencing analyses, blocks autophagy in a dose-dependent manner, and increases the sensitivity of glioblastoma to temozolomide in vivo. Together, this work reveals that TFEB is targetable and presents the first direct TFEB inhibitor EO, a drug compound with great potential to benefit a wide range of cancer therapies by inhibiting autophagy.
Multidimensional visualization of the dynamic evolution of Li metal via in situ/operando methods
Authors: Lang Shuangyan , Colletta Michael , Krumov Mihail R. , Seok Jeesoo , Kourkoutis Lena F. , Wen Rui , Abruña Héctor D. 
Published: February 2023

The growing demands for high-energy density electrical energy storage devices stimulate the coupling of conversion-type cathodes and lithium (Li) metal anodes. While promising, the use of these “Li-free” cathodes brings new challenges to the Li anode interface, as Li needs to be dissolved first during cell operation. In this study, we have achieved a direct visualization and comprehensive analysis of the dynamic evolution of the Li interface. The critical metrics of the interfacial resistance, Li growth, and solid electrolyte interface (SEI) distribution during the initial dissolution/deposition processes were systematically investigated by employing multidimensional analysis methods. They include three-electrode impedance tests, in situ atomic force microscopy, scanning electrochemical microscopy, and cryogenic scanning transmission electron microscopy. The high-resolution imaging and real-time observations show that a loose, diffuse, and unevenly distributed SEI is formed during the initial dissolution process. This leads to the dramatically fast growth of Li during the subsequent deposition, deviating from Fick’s law, which exacerbates the interfacial impedance. The compactness of the interfacial structure and enrichment of electrolyte species at the surface during the initial deposition play critical roles in the long-term stability of Li anodes, as revealed by operando confocal Raman spectroscopic mapping. Our observations relate to ion transfer, morphological and structural evolution, and Li (de)solvation at Li interfaces, revealing the underlying pathways influenced by the initial dissolution process, which promotes a reconsideration of anode investigations and effective protection strategies.
Early Vedic compounds
Authors: Biagetti Erica 
Published: February 2023

Abstract
Despite a longstanding tradition of studies in Sanskrit compounds, a description that enables comparisons in
cross-linguistic perspective has not yet been worked out. The present article follows classificatory criteria introduced by
Bisetto & Scalise (2005, 2009) and
sketches a typology of compounds in the most archaic variety of Sanskrit, Early Vedic, as transmitted by the
RigVeda. Analyzing compounds on the basis of the grammatical relations holding between their constituents
provides a classification into coordinate, subordinate, and attributive compounds, with the endocentric/exocentric divide cutting
across all classes. In order to identify the position of Early Vedic compounds on the syntax-morphology continuum,
the article investigates the degree of cohesiveness at the level of morphology, prosody, syntax, and semantics. With this respect,
the RigVeda offers a varied picture where relics of archaic, less cohesive forms occur side-to-side with more
productive and word-like ones.
Asymmetric supercapacitors based on SnNiCoS ternary metal sulfide electrodes
Authors: Dai Tingting , Cai Bin , Yang Xijia , Jiang Yi , Wang Liying , Wang Jiusheng , Li Xuesong , Lü Wei 
Published: February 2023

Abstract
While metal sulfides have extensively investigated as electrode materials for supercapacitors, the further optimization of their material system is still necessary to achieve satisfied performance. In this work, we reported the synthesis of ternary metal sulfide SnNiCoS and its application as electrode material of asymmetric supercapacitors, in which active carbon is used as the other electrode. For control experiments, asymmetric supercapacitors based on single metal sulfide CoS and binary metal sulfide NiCoS are also fabricated and investigated. The results show that the nanospherical SnNiCoS achieves the best performance. Ternary sulphide materials offer more redox than corresponding single-metal sulphides due to the synergy among various transition metal elements. The specific capacitance is 18.6 F cm−2 at current density of 5 mA·cm−2. An energy density of 937.2 μWh cm−2 is achieved at a power density of 4000 μW·cm−2. After 8000 cycles, the capacity retention rate is 82.9%. Present work indicates that SnNiCoS ternary metal sulfide could be a promising composite for high performance supercapacitors.
Chaotic image encryption based on spiral traversal and finite field bidirectional diffusion
Authors: Huang Lilian , Chai Bin , Xiang Jianhong , Zhang Zefeng , Liu Jin 
Published: February 2023

Abstract
In this paper, a new sinusoidal cascade chaotic map model is proposed, which constructs chaotic system by sinusoidal cascade of two identical 1D chaotic maps. This model can generate 1D chaotic system with wider parameter range and wider chaotic region. To verify its application in image encryption, a chaotic image encryption algorithm based on spiral traversal and finite field bidirectional diffusion is proposed. The pseudo-random sequences generated by three kinds of 1D chaotic maps improved by the sinusoidal cascade chaotic map model are used as the ciphers of the cryptosystem. Among them, SHA-256, SHA-512 and plain image are combined to generate the initial value of the system. The experimental results and security analysis show that the encryption algorithm designed in this paper can effectively resist exhaustive attack, differential attack, noise attack and so on, and the proposed model has superior performance in encryption speed and security.
The COLUTA ADC ASIC and the ATLAS HL-LHC Liquid Argon Front-End Readout
Authors: Matos G. 
Published: February 2023

Abstract
The upgraded High-Luminosity Large Hadron Collider (HL-LHC) requires a new radiation tolerant ATLAS Liquid Argon (LAr) Calorimeter readout operating at 40 MHz with 16-bit dynamic range. The Front-End Board 2 (FEB2) will provide the front-end readout for the calorimeter, and will interface a series of custom ASICs due to radiation tolerance requirements of the HL-LHC. The COLUTA is a 65 nm CMOS custom 8-channel 15-bit 40 MSPS ADC ASIC developed for this application. This contribution will present performance results of the final prototype of the COLUTA, surpassing specifications at >11.5 ENOB for relevant frequencies, as well as non-linearity and radiation requirements. Preliminary integration results of the front-end readout components will also be described by means of the FEB2 Pre-Prototype, the “Slice Testboard”.
Increased floodplain inundation in the Amazon since 1980
Authors: Fleischmann Ayan S , Papa Fabrice , Hamilton Stephen K , Fassoni-Andrade Alice , Wongchuig Sly , Espinoza Jhan-Carlo , Paiva Rodrigo C D , Melack John M , Fluet-Chouinard Etienne , Castello Leandro , Almeida Rafael M , Bonnet Marie-Paule , Alves Luna G , Moreira Daniel , Yamazaki Dai , Revel Menaka , Collischonn Walter 
Published: February 2023

Abstract
Extensive floodplains throughout the Amazon basin support important ecosystem services and influence global water and carbon cycles. A recent change in the hydroclimatic regime of the region, with increased rainfall in the northern portions of the basin, has produced record-breaking high water levels on the Amazon River mainstem. Yet, the implications for the magnitude and duration of floodplain inundation across the basin remain unknown. Here we leverage state-of-the-art hydrological models, supported by in-situ and remote sensing observations, to show that the maximum annual inundation extent along the central Amazon increased by 26% since 1980. We further reveal increased flood duration and greater connectivity among open water areas in multiple Amazon floodplain regions. These changes in the hydrological regime of the world’s largest river system have major implications for ecology and biogeochemistry, and require rapid adaptation by vulnerable populations living along Amazonian rivers.