bluuebunny/crossref_metadata_2025_split huggingface dataset:
Voice coil motor-driven multi-DOF compliant parallel micropositioning stage based on a large range beam-based spherical hinge and fully symmetrical layout
Authors: Chen Yunzhuang , Lai Leijie , Fang Yu , Zhu Limin 
Published: July 2023

Abstract
With the recent rapid developments in the field of precision engineering, demand for the large range multi-degrees-of-freedom (DOF) micropositioning stage has increased significantly. In this paper, to solve the problems of small motion range, local stress concentration, and low motion accuracy caused by the parasitic motion of the traditional flexure hinge in the multi-DOF micropositioning stage, we first propose a type of large-range beam-based flexure spherical hinge (BFSH). Subsequently, based on the proposed BFSH, a large range 3-DOF θxθyz spatial micropositioning stage driven by the voice coil motor is designed employing parallel branch chains and a fully symmetrical layout. This arrangement realizes theoretical motion decoupling in structural design. Furthermore, we use the geometric method to derive kinematic equations of the moving platform, which are used as the decoupling matrix of the control loop. Based on the compliance matrix method and Lagrange’s method, the compliance matrix model of the BFSH, the 3-DOF micropositioning stage, and the stage dynamic model are determined respectively. Additionally, finite element analysis and experimental tests are conducted to verify the accuracy of the analytical model and assess the static and dynamic performance of the designed 3-DOF stage. Moreover, a fractional order phase advanced proportional integral controller is designed for closed-loop control to track the sinusoidal trajectory and spherical trajectory. The results reveal that the stage can achieve the desired large workspace of ± 21.5 mrad × ± 20.3 mrad × ± 3.23 mm, as well as excellent decoupling and trajectory tracking performance.
Improvement of VMD for anomalous collision disturbance based on nonlinear l
1/2 norm
Authors: Han Baokun , Yao Shunxiang , Zhang Zongzhen , Wang Jinrui , Yang Zujie , Ma Hao , Xing Shuo , Wei Yongchang 
Published: July 2023

Abstract
Variational mode decomposition (VMD) is widely used in the fault diagnosis of rotating equipment. The kurtosis index is typically utilized as the objective function to determine the optimal decomposition mode in conventional VMD. However, kurtosis is easily interfered with by abnormal impact signals, seriously affecting the accuracy of VMD in the fault extraction process. Therefore, the instability of the kurtosis index for anomalous disturbances should be addressed. In addition, the number of modal decompositions

K

and the penalty factor

α

are not wisely selected, exerting a significant influence on the decomposition effect of VMD. In this study, we propose an enhanced method for fault diagnosis of rotating machineries under abnormal impact interference, namely the improved nonlinear VMD method based on the l
1/2 norm (INVL). Initially, we employ the whale optimization algorithm to optimize the combination of parameters [

K
,
α

] with the aim of achieving the most favorable decomposition outcomes. Subsequently, the decomposed modes undergo preprocessing using the nonlinear tanh function to mitigate the impact of amplitude shocks. Furthermore, we utilize the sparse l
1/2 norm to select fault feature components, thereby evaluating the sparse distribution of modes. The modes exhibiting the lowest l
1/2-norm values are chosen for information reconstruction and envelope analysis. To assess the effectiveness of the proposed method, we conduct simulations and experimental verifications. The results demonstrate that the INVL method effectively suppresses abnormal shocks and successfully extracts bearing fault features in the presence of anomalous collision disturbances.
Recent research trends in textile-based temperature sensors: a mini review
Authors: Ha Heebo , Suryaprabha Thirumalaisamy , Choi Chunghyeon , Chandio Zubair Ahmed , Kim Byungjin , Lim Sooman , Cheong Jun Young , Hwang Byungil 
Published: July 2023

Abstract
In this review, the current state of research on textile-based temperature sensors is explored by focusing on their potential use in various applications. The textile-based sensors show various advantages including flexibility, conformability and seamlessness for the wearer. Integration of the textile-based sensors into clothes or fabric-based products enables continuous and sensitive monitoring of change in temperature, which can be used for various medical and fitness applications. However, there are lacks of comprehensive review on the textile-based temperature sensors. This review introduces various types of textile-based temperature sensors, including resistive, thermoelectric and fibre-optical sensors. In addition, the challenges that need to be addressed to fully realise their potential, which include improving sensitivity and accuracy, integrating wireless communication capabilities, and developing low-cost fabrication techniques. The technological advances in textile-based temperature sensors to overcome the limitations will revolutionize wearable devices requiring function of temperature monitoring.
Engineering buffer layers to improve temperature resilience of magnetic tunnel junction sensors
Authors: Araujo P D R , Macedo R , Paz E , Cardoso S , Leitao D C , Freitas P P 
Published: July 2023

Abstract
Improving the thermal resilience of magnetic tunnel junctions (MTJs) broadens their applicability as sensing devices and is necessary to ensure their operation under harsh environments. In this work, we are address the impact of temperature on the degradation of the magnetic reference in field sensor stacks based on MgO-MTJs. Our study starts by simple MnIr/CoFe bilayers to gather enough insights into the role of critical morphological and magnetic parameters and their impact in the temperature dependent behavior. The exchange bias coupling field (H
ex), coercive field (H
c), and blocking temperature (T
b) distribution are tuned, combining tailored growth conditions of the antiferromagnet and different buffer layer materials and stackings. This is achieved by a unique combination of ion beam deposition and magnetron sputtering, without vaccum break. Then, the work then extends beyond bilayers into more complex state-of-the-art MgO MTJ stacks as those employed in commercial sensing applications. We systematically address their characteristic fields, such as the width of the antiferromagnetic coupling plateau ΔH, and study their dependence on temperature. Although, [Ta/CuN] buffers showed higher key performance indications (e.g. H
ex) at room temperature in both bilayers and MTJs, [Ta/Ru] buffers showed an overall wider ΔH up to 200 °C, more suitable to push high temperature operations. This result highlights the importance of properly design a suitable buffer layer system and addressing the complete MTJ behavior as function of temperature, to deliver the best stacking design with highest resilience to high temperature environments.
Equal parallel and cone-beam projections: a curious property of D-symmetric object functions
Authors: Clackdoyle Rolf , Rit Simon 
Published: July 2023

Abstract
In tomographic image reconstruction, the object density function is the unknown quantity whose projections are measured by the scanner. In the three-dimensional case, we define the D-reflection of such a density function as the object obtained by a particular weighted reflection about the plane z = D, and a D-symmetric function as one whose D-reflection is equal to itself. D-symmetric object functions have the curious property that their parallel projection onto the detector plane z = D is equal to their cone-beam projection onto the same detector with x-ray source location at the origin. Much more remarkable is the additional fact that for any fixed D-symmetric object, every oblique parallel projection onto this same detector plane equals the cone-beam projection for a corresponding source location. The mathematical proof is straight forward but not particularly enlightening, and we also provide here an alternative physical demonstration that explains the various weighting terms in the context of classical tomosynthesis. Furthermore, we clarify the distinction between the new formulation presented here, and the original formulation of Edholm and co-workers who obtained similar properties but for a pair of objects whose divergent and parallel projections matched, but with no D-symmetry. We do not claim any immediate imaging application or useful physics from these notions, but we briefly comment on consequences for methods that apply data consistency conditions in image reconstruction.
Impact of toroidal rotation on the resistive ballooning modes in ASDEX Upgrade tokamak
Authors: Vanovac B , Puchmayr J , Bielajew R , Willensdorfer M , Wolfrum E , Cavedon M , Strumberger E , Dunne M G , Suttrop W 
Published: July 2023

Abstract
In this work, we investigate the behavior of instabilities appearing between type-I edge localized modes (ELMs), with increasing neutral beam injection (NBI) power concomitant increase in toroidal rotation, and compare it to the modeling result of the linear magneto-hydrodynamic (MHD) code CASTOR3D. An injection of one NBI beam, increasing toroidal rotation, results in the mode slowing down from 12 kHz to 7 kHz, and its associated radial displacement decreases from 5 mm to 3.5 mm. In addition, modes shift radially outwards towards higher q, decreasing their poloidal mode numbers. The mode velocity is measured to be close to the E × B velocity with significant uncertainties. Through a set of CASTOR3D simulations with varying profiles, resistivity has been identified as the primary contributor to the growth rates. Only a small stabilizing effect due to toroidal rotation has been observed. While experimental results show a decrease of mode frequency with rotation, the opposite trend is observed in modeling. Reasons for discrepancies between modeling and experiment are discussed. Nevertheless, a main contributor to the mode frequency has been identified to be rotation velocity. CASTOR3D classifies modes as resistive ballooning modes as they do not appear unstable in ideal MHD.
GradPose: a very fast and memory-efficient gradient descent-based tool for superimposing millions of protein structures from computational simulations
Authors: Rademaker Daniel T , van Geemen Kevin J , Xue Li C 
Published: July 2023

Abstract

Summary
Computational simulations like molecular dynamics and docking are providing crucial insights into the dynamics and interaction conformations of proteins, complementing experimental methods for determining protein structures. These methods often generate millions of protein conformations, necessitating highly efficient structure comparison and clustering methods to analyze the results. In this article, we introduce GradPose, a fast and memory-efficient structural superimposition tool for models generated by these large-scale simulations. GradPose uses gradient descent to optimally superimpose structures by optimizing rotation quaternions and can handle insertions and deletions compared to the reference structure. It is capable of superimposing thousands to millions of protein structures on standard hardware and utilizes multiple CPU cores and, if available, CUDA acceleration to further decrease superimposition time. Our results indicate that GradPose generally outperforms traditional methods, with a speed improvement of 2–65 times and memory requirement reduction of 1.7–48 times, with larger protein structures benefiting the most. We observed that traditional methods outperformed GradPose only with very small proteins consisting of ∼20 residues. The prerequisite of GradPose is that residue–residue correspondence is predetermined. With GradPose, we aim to provide a computationally efficient solution to the challenge of efficiently handling the demand for structural alignment in the computational simulation field.

Availability and implementation
Source code is freely available at https://github.com/X-lab-3D/GradPose; doi:10.5281/zenodo.7671922.
5-Year haemodynamic performance of three aortic bioprostheses. A randomized clinical trial
Authors: Montero Cruces Lourdes , Carnero Alcázar Manuel , Pérez Camargo Daniel , Cobiella Carnicer Javier , Campelos Fernández Paula , Reguillo Lacruz Fernando José , Maroto Castellanos Luis Carlos 
Published: July 2023

Abstract

OBJECTIVES
The Carpentier Perimount (CP) Magna Ease, the Crown Phospholipid Reduction Treatment (PRT) and the Trifecta bovine pericardial valves have been widely used worldwide. The primary end point of this study was to compare the haemodynamic performance quantified by in vivo echocardiograms of these 3 aortic prostheses.

METHODS
The “BEST-VALVE” (comparison of 3 contemporary cardiac bioprostheses: mid-term valve haemodynamic performance) was a single-centre randomized clinical trial to compare the haemodynamic and clinical outcomes of the aforementioned bioprostheses. The 5-year results are assessed in this manuscript.

RESULTS
A total of 154 patients were included. The CP Magna Ease (n = 48, 31.2%), Crown PRT (n = 51, 32.1%) and Trifecta (n = 55, 35.7%) valves were compared. Significant differences were observed among the 3 bioprostheses 5 years after the procedure. The following haemodynamic differences were found between the CP Magna Ease and the Crown PRT bioprostheses [mean aortic gradient: 12.3 mmHg (interquartile range {IQR} 7.8–17.5) for the CP Magna Ease vs 15 mmHg (IQR 10.8–31.9) for the Crown PRT, P &lt; 0.001] and between the CP Magna Ease and the Trifecta prostheses [mean aortic gradient: 12.3 mmHg (IQR 7.8–17.5) for the CP Magna Ease vs 14.7 mmHg (IQR 8.2–55) for the Trifecta, P &lt; 0.001], with a better haemodynamic performance of the CP Magna Ease. The cumulative incidence of severe structural valve degeneration was 9.5% in the Trifecta group at 6 years of follow-up. The 1-, 3- and 5-year survival from all-cause mortality was 91.5%, 83.5% and 74.8%, respectively (log rank P = 0.440). Survival from the composite event at the 1-, 3- and 5-year follow-up was 92.8%, 74.6% and 59%, respectively (log rank P = 0.299).

CONCLUSIONS
We detected significant differences between the 3 bioprostheses; the CP Magna Ease had the best haemodynamic performance at the 5-year follow-up.
Balloon pulmonary angioplasty for chronic thromboembolic pulmonary hypertension: a clinical consensus statement of the ESC working group on pulmonary circulation and right ventricular function
Authors: Lang Irene M , Andreassen Arne K , Andersen Asger , Bouvaist Helene , Coghlan Gerry , Escribano-Subias Pilar , Jansa Pavel , Kopec Grzegorz , Kurzyna Marcin , Matsubara Hiromi , Meyer Bernhard Christian , Palazzini Massimiliano , Post Marco C , Pruszczyk Piotr , Räber Lorenz , Roik Marek , Rosenkranz Stephan , Wiedenroth Christoph B , Redlin-Werle Carlo , Brenot Philippe 
Published: July 2023

Abstract
The current treatment algorithm for chronic thromboembolic pulmonary hypertension (CTEPH) as depicted in the 2022 European Society of Cardiology (ESC)/European Respiratory Society (ERS) guidelines on the diagnosis and treatment of pulmonary hypertension (PH) includes a multimodal approach of combinations of pulmonary endarterectomy (PEA), balloon pulmonary angioplasty (BPA) and medical therapies to target major vessel pulmonary vascular lesions, and microvasculopathy. Today, BPA of &gt;1700 patients has been reported in the literature from centers in Asia, the US, and also Europe; many more patients have been treated outside literature reports. As BPA becomes part of routine care of patients with CTEPH, benchmarks for safe and effective care delivery become increasingly important. In light of this development, the ESC Working Group on Pulmonary Circulation and Right Ventricular Function has decided to publish a document that helps standardize BPA to meet the need of uniformity in patient selection, procedural planning, technical approach, materials and devices, treatment goals, complications including their management, and patient follow-up, thus complementing the guidelines. Delphi methodology was utilized for statements that were not evidence based. First, an anatomical nomenclature and a description of vascular lesions are provided. Second, treatment goals and definitions of complete BPA are outlined. Third, definitions of complications are presented which may be the basis for a standardized reporting in studies involving BPA. The document is intended to serve as a companion to the official ESC/ERS guidelines.
Deep sedation protocol during atrial fibrillation ablation using a novel variable-loop biphasic pulsed field ablation catheter
Authors: Grimaldi Massimo , Quadrini Federico , Caporusso Nicola , Troisi Federica , Vitulano Nicola , Delmonte Vito , Di Monaco Antonio 
Published: July 2023

Abstract

Background
Pulsed field ablation (PFA) is a novel, largely nonthermal ablative modality that, by virtue of its putative preferential action on myocardial tissue through the process of irreversible electroporation (IRE), may replace conventional thermal ablation for atrial fibrillation (AF). The recent inspIRE study confirmed safety and effectiveness of a fully integrated biphasic PFA system with a variable loop circular catheter for the treatment of paroxysmal AF. The majority of PFA procedures were performed using general anesthesia. However, due to the risks of general anesthesia we report the data regarding our sedation protocol used during inspIRE study.

Methods
A total of 29 patients (mean age 55±9 years; 72% male) were enrolled as part of this analysis within the inspIRE trial. The sedation protocol is reported in the manuscript. The Richmond Agitation-Sedation Scale (RASS), the Visual Analogue Scale (VAS) and the Patient State Index were collected during sedation. Each patient was monitored using the Masimo Sedline. At the end of ablation, the Likert Scale Questionnaire (LSQ) was used to assess the patients' satisfaction with intraoperative analgesia-sedation.

Results
No procedural complications were documented. Sufficient oxygen saturation was maintained in all patients during procedure. Non-invasive ventilation or tracheal intubation were not required for any patient. The RAAS score between -1 to -5 was obtained in 27 patients (93%) while the value 0 was obtained in 2 patients (7%). The VAS score between 0 to 2 was obtained in 24 patients (83%); the VAS score 3 in 3 patients (10%) and the VAS score 4 in 2 patients (7%). The PSI score &lt;50 was achieved in 16 patients (55%) while the PSI between 50 and 70 was achieved in 9 patients (31%). Positive answers to LSQ were obtained in most patients.

Conclusion
During PFA ablation procedures with the variable-loop circular catheter and its accompanying biphasic pulse, our deep sedation protocol is a valid alternative to general anesthesia.
Contemporary human H3N2 influenza A viruses require a low threshold of suitable glycan receptors for efficient infection
Authors: Spruit Cindy M , Sweet Igor R , Maliepaard Joshua C L , Bestebroer Theo , Lexmond Pascal , Qiu Boning , Damen Mirjam J A , Fouchier Ron A M , Reiding Karli R , Snijder Joost , Herfst Sander , Boons Geert-Jan , de Vries Robert P 
Published: July 2023

Abstract
Recent human H3N2 influenza A viruses have evolved to employ elongated glycans terminating in α2,6-linked sialic acid as their receptors. These glycans are displayed in low abundancies by (humanized) Madin-Darby Canine Kidney cells, which are commonly employed to propagate influenza A virus, resulting in low or no viral propagation. Here, we examined whether the overexpression of the glycosyltransferases β-1,3-N-acetylglucosaminyltransferase and β-1,4-galactosyltransferase 1, which are responsible for the elongation of poly-N-acetyllactosamines (LacNAcs), would result in improved A/H3N2 propagation. Stable overexpression of β-1,3-N-acetylglucosaminyltransferase and β-1,4-galactosyltransferase 1 in Madin-Darby Canine Kidney and “humanized” Madin-Darby Canine Kidney cells was achieved by lentiviral integration and subsequent antibiotic selection and confirmed by qPCR and protein mass spectrometry experiments. Flow cytometry and glycan mass spectrometry experiments using the β-1,3-N-acetylglucosaminyltransferase and/or β-1,4-galactosyltransferase 1 knock-in cells demonstrated increased binding of viral hemagglutinins and the presence of a larger number of LacNAc repeating units, especially on “humanized” Madin-Darby Canine Kidney–β-1,3-N-acetylglucosaminyltransferase cells. An increase in the number of glycan receptors did, however, not result in a greater infection efficiency of recent human H3N2 viruses. Based on these results, we propose that H3N2 influenza A viruses require a low number of suitable glycan receptors to infect cells and that an increase in the glycan receptor display above this threshold does not result in improved infection efficiency.
Mapping microRNA expression quantitative trait loci in the prenatal human brain implicates miR-1908-5p expression in bipolar disorder and other brain-related traits
Authors: Toste Carolina C , O’Donovan Michael C , Bray Nicholas J 
Published: July 2023

Abstract
MicroRNA (miRNA) are small non-coding RNA involved in post-transcriptional gene regulation. Given their known involvement in early neurodevelopment processes, we here sought to identify common genetic variants associated with altered miRNA expression in the prenatal human brain. We performed small RNA sequencing on brain tissue from 112 genome-wide genotyped fetuses from the second trimester of gestation, identifying high-confidence (false discovery rate &lt; 0.05) expression quantitative trait loci for 30 mature miRNA. Integrating our findings with genome-wide association study data for brain-related disorders, we implicate increased prenatal expression of miR-1908-5p as a risk mechanism for bipolar disorder and find that predicted mRNA targets of miR-1908-5p that are expressed in the fetal brain are enriched for common variant genetic association with the condition. Extending these analyses to other brain-related traits, we find that common genetic variation associated with increased miR-1908-5p expression in fetal brain is additionally associated with depressive symptoms, irritability, increased right cerebellum exterior volume and increased sleep duration in the general population. Our findings provide support to the view that altered miRNA expression can influence susceptibility to neuropsychiatric illness and suggest an early neurodevelopmental risk mechanism for bipolar disorder.
Learning Chinese Calligraphy in VR With Sponge-Enabled Haptic Feedback
Authors: Luo Guoliang , Lu Tingsong , Xia Haibin , Hu Shicong , Guo Shihui 
Published: July 2023

Abstract
Nowadays, virtual reality (VR) is becoming an important technique for various educational subjects. However, Chinese calligraphy, as a unique artistic form, remains under-explored in terms of learning in a VR configuration. This deficiency is largely due to the challenge to render delicate haptic feedback of pen and brush during the process of writing. To achieve the purpose of haptic rendering, existing works mostly use the professional device (e.g. Phantom), which is expensive and not accessible to common users. Our work presents a novel yet simple approach to render haptic feedback for Chinese calligraphy in VR by using soft and deformable sponge as the medium between the handheld controller and writing surface. We compared three different feedback configurations using on-device vibration and sponge-enabled haptic feedback against the baseline configuration with no force feedback. Based on both the qualitative and quantitative results from user studies, we found that sponge-based haptic feedback not only provided a comfort experience of interactive virtual writing but also accelerated the learning performance of novices. Our approach is low cost, scalable and produces realistic user experience, which offers an alternative solution for future development of training systems for virtual Chinese calligraphy.