bluuebunny/crossref_metadata_2025_split huggingface dataset:
How different regional approaches to the network design result in key differences in burst event severity and failure vulnerability
Authors: Gibson John H. , Karney Bryan 
Published: August 2023

Abstract

The pipe burst response of an innovative Dutch water distribution network is compared to a traditional looped North American network. Dutch networks focus on water quality and use smaller diameter pipes in branches. The branched network discharges much less water after a burst, which may reduce local flooding, traffic disruption, and product loss. In addition, high velocities and transient pressures are shown to be much localized in the branched Dutch network after a burst, reducing the risks associated with the intrusion of contaminants. However, despite improved water quality, less water loss, and more localized transients, the branched network cannot meet water demands downstream of the burst until the pipe is repaired, unlike a traditional looped network. For modern buildings that meet current design guidelines, the Dutch are content with much lower fire-flow requirements that provide the flexibility to improve water quality and reduce the consequences of pipe bursts, especially water loss.
Mechanisms Involved in the Therapeutic Effect of Cannabinoid
Compounds on Gliomas: A Review with Experimental Approach
Authors: Pires Hugo Fernandes Oliveira , da Silva Pablo Rayff , Dias Arthur Lins , de Sousa Gomes Cleyton , de Sousa Natália Ferreira , dos Santos Aline Matilde Ferreira , Souza Lívia Roberta Pimenta , de Figueiredo Lima Jaislânia Lucena , Oliveira Mayara Cecile Nascimento , Felipe Cícero Francisco Bezerra , de Almeida Reinaldo Nóbrega , de Castro Ricardo Dias , da Silva Stiebbe Salvadori Mirian Graciela , Scotti Marcus Tullius , Scotti Luciana 
Published: August 2023

Introduction:
Brain tumors have high morbidity and mortality rates, accounting for
1.4% of all cancers. Gliomas are the most common primary brain tumors in adults. Currently, several
therapeutic approaches are used; however, they are associated with side effects that affect patients’quality
of life. Therefore, further studies are needed to develop novel therapeutic protocols with a
more favorable side effect profile. In this context, cannabinoid compounds may serve as potential
alternatives.

Objective:
This study aimed to review the key enzymatic targets involved in glioma pathophysiology
and evaluate the potential interaction of these targets with four cannabinoid derivatives through
molecular docking simulations.

Methods:
Molecular docking simulations were performed using four cannabinoid compounds and
six molecular targets associated with glioma pathophysiology.

Results:
Encouraging interactions between the selected enzymes and glioma-related targets were
observed, suggesting their potential activity through these pathways. In particular, cannabigerol
showed promising interactions with epidermal growth factor receptors and phosphatidylinositol 3-
kinase, while Δ-9-tetrahydrocannabinol showed remarkable interactions with telomerase reverse
transcriptase.

Conclusion:
The evaluated compounds exhibited favorable interactions with the analyzed enzymatic
targets, thus representing potential candidates for further in vitro and in vivo studies.
Exploring Applications of Flexible Vesicular Systems as Transdermal
Drug Delivery
Authors: Kaur Palwinder , Verma Surajpal , Tomar Bhupendra , Vyas Manish , Kakoty Violina , Saha Paramita , Kalarikkal Chandran Sarathlal 
Published: August 2023

Abstract:
Deformable lipidic-nano carriers are a category of advanced liposomal formulations. Deformable
lipidic-nano carriers have a specific character to transform by rearranging the lipidic backbone
to squeeze themself through a pore opening ten times smaller than their diameter when exposed to a
variable condition like hydration gradient as these have potentially been used as a non-invasive delivery
system to transdermally migrate various therapeutic agents for over three decades. Despite their vast
application in transdermal drug delivery system, non-uniformity to express their chemical nature still
exist and authors use various terms synonymously and interchangeably with each other.

:
The present study delineates the terminologies used to express different derived deformable vesicular
carriers to harmonize the terminological use. It also includes the effectiveness of deformable nanocarriers
like Transferosomes, Ethosomes, Menthosomes, Invasomes, and Glycerosomes in skin conditions
like basal cell carcinoma, fungal and viral infections, and hyperpigmentation disorders, along with
others.

:
Various review and research articles were selected from the ‘Pubmed’ database. The keywords like
Transferosomes, Flexi-vesicular system, ultra-deformable vesicles, and nano-vesicular systems were
used to extract the data.

:
The data was reviewed and compiled to categorically classify different flexible vesicular systems. The
composition of the different vesicular systems is identified and a report of various pathological conditions
where the use of flexible lipid nanocarrier systems was implemented is compiled. The review also
offers suggestive approaches where the applicability of these systems can be explored further.
Diagnostic Reliability of Plain Radiography in Osteonecrosis of the Femoral
Head: General Radiological Features Revised
Authors: Cardín-Pereda Adrian , García-Sánchez Daniel , Terán-Villagrá Nuria , Alfonso-Fernández Ana , Fakkas Michel , Pérez-del Barrio Amaia , Marín-Díez Elena , Fernández-Lobo Víctor , Sanz-Bellón Pablo , Montes-Figueroa Enrique , Lamprecht Yasmina , Pérez-Campo Flor María 
Published: August 2023

Background and Objectives:
Osteonecrosis of the femoral head (ONFH) is an incapacitating disease that frequently results in the collapse of the femoral head and secondary osteoarthritis. The diagnosis and staging of this pathology, which usually rely on imaging studies, are challenging. Currently, conventional radiography is the basis of the initial diagnostic assessment. In recent decades, however, radiographs have been considered insensitive to early changes in ONFH and thus, a suboptimal diagnostic tool. Paradoxically, the imaging features of radiographs are often profuse, substantial, and characteristic. This study aimed to elucidate the real limitations of this radiologic tool by assessing the diagnostic reliability of the key radiologic features and staging.

Methods:
This was a retrospective study in which radiographs from 28 idiopathic ONFH confirmed cases who underwent hip arthroplasty were analyzed by eight observers who were asked to identify the presence or absence of ONFH universally reported imaging features in AP hip radiographs.

Results:
Concordance analysis revealed a poor agreement between observers for most of the assessed imaging features. Only the identification of femoral head flattening and osteoarthritis signs exhibited moderate agreement with statistical significance. In contrast, the detection of radiological osteoporosis and the loss of trabeculation showed the lowest reliability, with negative kappa coefficients.

Conclusion:
There is a lack of agreement between qualified observers, even for the identification of the most characteristic ONFH radiographic feature. The reliability of plain radiography for the detection of basic radiological elements is even weaker in the early stages of the disease.
VALUATION OF TRANSPORTATION POLICY IN MAKASSAR CITY BASED ON VEHICLE EMISSION POLLUTION FOR SUSTAINABLE ZONE PLANNING
Authors: Mansyur Umar , R.P. Sitorus Santun , Marimin  , Prasetyo Lilik Budi 
Published: August 2023

City expansion, vehicle growing number, fossil fuel consumption as non-renewable energy, and highest carbon emission has increased green house effect with potentially expanding global warming. Global warming has negative impacts on citizen quality of life as well as economic growth. Makassar City as one of the metropolitan in Indonesia with the high number of vehicle has a potential to endure global warming. This is excarbated by the decreasing environmental carrying capacity caused by household and industrial pollution and greater vehicle emission. This study aims to (1) identify the vehicle emission gas using descriptive analysis, (2) evaluate ambient air quality in several locations within Makassar City based on field measurement, and (3) formulate the zone plan with potential vehicle-sourced high pollution using AHP. It can be concluded from this study that 99% of Makassar City’s pollution is caused by vehicle emissions with specifically refers to vehicle ages, car engine types, and low maintenance. It is found that high pollution level occurs in the suburbs, while medium pollution level happens in the transition zone and low level of pollution in city center. Urban infrastructure improvement is carried out by Makassar City Development Agency (Bappeda) with consistency ratio between 0.05 and 0.06.
Advanced Messaging Intervention for Medication Adherence and Clinical Outcomes Among Patients With Cancer: Randomized Controlled Trial
Authors: Ni Chen-Xu , Lu Wen-Jie , Ni Min , Huang Fang , Li Dong-Jie , Shen Fu-Ming 
Published: August 2023

Background
Medication adherence is crucial for improving clinical outcomes in the treatment of patients with cancer. The lack of adherence and adverse drug reactions can reduce the effectiveness of cancer therapy including the quality of life. The commonly used intervention methods for medication adherence continue to evolve, and the age of fifth-generation (5G) messaging has arrived.

Objective
In this study, we conducted a prospective, pilot randomized controlled trial to evaluate the effect of 5G messaging on medication adherence and clinical outcomes among patients with cancer in China.

Methods
The research population was patients with nonsmall cell lung cancer undergoing pemetrexed chemotherapy who require regular folic acid (FA) and vitamin B12 supplements. The intervention and control groups were assigned to 5G messaging and second-generation (2G) messaging, respectively. The patients’ medication adherence and quality of life were assessed at baseline and 1-month and 3-month time points. Moreover, the chemotherapy-related hematologic or nonhematologic toxicities, as well as the serum levels of FA and vitamin B12, were measured.

Results
Of the 567 patients assessed for eligibility between January and May 2021, a total of 154 (27.2%) patients were included. Overall, 80 were randomized to the control group and 74 to the intervention group. The odds of adherence in the 5G messaging intervention group were significantly higher than the control group at the 1-month (62/69, 90% vs 56/74, 76%; adjusted odds ratio 2.67, 95% CI 1.02-7.71) and 3-month (50/60, 83% vs 48/64, 75%; adjusted odds ratio 2.36, 95% CI 1.00-5.23) time points. Correspondingly, the FA and vitamin B12 serum levels of patients in the 5G messaging group were higher than those of the control group. Regarding hematologic toxicities, only the incidence of leukopenia in the intervention group was lower than that in the control group (25/80, 31% in the control group vs 12/74, 16% in the intervention group; P=.04). There were no differences in nonhematologic toxicities and quality of life between the 2 groups.

Conclusions
In summary, we conclude that compared with conventional 2G text-based messaging, a 5G messaging intervention can better improve medication adherence and clinical outcome among patients with cancer.

Trial Registration
Chinese Clinical Trial Registry ChiCTR2200058188; https://www.chictr.org.cn/showproj.html?proj=164489
Consolidated Reporting Guidelines for Prognostic and Diagnostic Machine Learning Modeling Studies: Development and Validation
Authors: Klement William , El Emam Khaled 
Published: August 2023

Background
The reporting of machine learning (ML) prognostic and diagnostic modeling studies is often inadequate, making it difficult to understand and replicate such studies. To address this issue, multiple consensus and expert reporting guidelines for ML studies have been published. However, these guidelines cover different parts of the analytics lifecycle, and individually, none of them provide a complete set of reporting requirements.

Objective
We aimed to consolidate the ML reporting guidelines and checklists in the literature to provide reporting items for prognostic and diagnostic ML in in-silico and shadow mode studies.

Methods
We conducted a literature search that identified 192 unique peer-reviewed English articles that provide guidance and checklists for reporting ML studies. The articles were screened by their title and abstract against a set of 9 inclusion and exclusion criteria. Articles that were filtered through had their quality evaluated by 2 raters using a 9-point checklist constructed from guideline development good practices. The average κ was 0.71 across all quality criteria. The resulting 17 high-quality source papers were defined as having a quality score equal to or higher than the median. The reporting items in these 17 articles were consolidated and screened against a set of 6 inclusion and exclusion criteria. The resulting reporting items were sent to an external group of 11 ML experts for review and updated accordingly. The updated checklist was used to assess the reporting in 6 recent modeling papers in JMIR AI. Feedback from the external review and initial validation efforts was used to improve the reporting items.

Results
In total, 37 reporting items were identified and grouped into 5 categories based on the stage of the ML project: defining the study details, defining and collecting the data, modeling methodology, model evaluation, and explainability. None of the 17 source articles covered all the reporting items. The study details and data description reporting items were the most common in the source literature, with explainability and methodology guidance (ie, data preparation and model training) having the least coverage. For instance, a median of 75% of the data description reporting items appeared in each of the 17 high-quality source guidelines, but only a median of 33% of the data explainability reporting items appeared. The highest-quality source articles tended to have more items on reporting study details. Other categories of reporting items were not related to the source article quality. We converted the reporting items into a checklist to support more complete reporting.

Conclusions
Our findings supported the need for a set of consolidated reporting items, given that existing high-quality guidelines and checklists do not individually provide complete coverage. The consolidated set of reporting items is expected to improve the quality and reproducibility of ML modeling studies.
ANALISIS BASIS SUBSEKTOR PERTANIAN DI PROVINSI SULAWESI TENGAH
Authors: Tangkelangi Sandarupa , Lamusa Arifuddin , Hadayani Hadayani 
Published: August 2023

Tujuan dari penelitian ini adalah untuk mengetahui subsektor pertanian basis di Sulawesi Tengah pada saat ini dan dimasa yang akan dating, dengan menggunakan data sekunder. Analisis data menggunakan metode LQ dan DLQ. Berdasarkan hasil analisis Location Quotient, subsektor perkebunan, kehutanan serta perikanan adalah subsektor basis dengan rata-rata nilai LQ>1. Subsektor tanaman pangan, tanaman hortikultura serta peternakan adalah subsektor non basis dengan rata-rata nilai LQ<1 pada sektor pertanian di Provinsi Sulawesi Tengah. Hasil analisis Dynamic Location Quotient, subsektor tanaman pangan, tanaman perkebunan, tanaman hortikultura, kehutanan, perikanan dan peternakan adalah subsektor basis di masa yang akan datang pada sektor pertanian di Provinsi Sulawesi Tengah dengan rata-rata nilai DLQ>1.
The Effect Of Adding Isolate Soy Protein And Porang Flour Towards Tilapia Sausage Organoleptic
Authors: Aslim Fauzyah , Faridah Anni , Kasmita Kasmita , Holinesti Rahmi 
Published: August 2023

This research was motivated by the use of fish as the main ingredient in making sausages which are still rarely found. Tilapia is one of the leading sources of animal protein in fisheries in Indonesia because of its easy cultivation. The addition of soy protein isolate and porang flour in this study is as a binder and sausage filler. The purpose of this research was to analyze the organoleptic properties of tilapia sausage with the addition of soy protein isolate and porang flour. This study used a Complete Randomized Design method (RAL) with 4 treatments and 3 repeats. The research data was obtained from organoleptic tests by 5 limited panelists in May 2023 at the Culinary Workshop of Padang State University. Data were analyzed using Analysis of Variance (ANAVA), if Fcount > Ftable then Duncan's Test was continued. The results showed that there was a significant influence on texture. While shape, color, odor and taste did not show a significant effect. Overall, the best results of this study were found in X2 treatment with the addition of soy protein isolate and porang flour 1: 1.
Anaerobic Digestion and Composting as Methods of Bio-Waste Management
Authors: Czekała Wojciech , Nowak Mateusz , Bojarski Wiktor 
Published: August 2023

Abstract
The management of biodegradable waste from various sectors of economy is an essential element in terms of environmental protection. The paper discusses issues related to the possibility of bio-waste treatment using anaerobic digestion technologies and composting processes, highlighting the conditions for the processes and their advantages and disadvantages. The challenges of overproduction of bio-waste faced by highly developed countries around the world are also presented. Research showed that the anaerobic digestion of this waste combines both biofuel production and a circular economy. The popularity of this method is linked, among others to a low cost of raw materials and wide range of possible uses for biogas (i.e. electricity, heat, or biomethane). In addition, an alternative bio-waste management option, compost production, was discussed. The study aimed to compare anaerobic and aerobic bio-waste management processes.
Modeling the Shape of Wheat Kernels with the Use of Solids of Revolution
Authors: Anders Andrzej 
Published: August 2023

Abstract
Numerical models approximating a kernel shape in wheat cv. Eta were developed with the use of a 3D scanner and applied to analyze selected geometric properties of wheat kernels. Geometric models were built in ScanStudio HD PRO, FreeCAD, and MeshLab programs. Ten geometric models describing the shape of wheat kernels were generated with the use of basic geometric figures and drawing tools in FreeCAD. The geometry of numerical models and geometric models was compared in GOM Inspect. The surface area, volume, and accurate geometric dimensions of the developed models were determined. Deviations in the dimensions of geometric models were mapped. The relative error of surface area measurements was the lowest in solid of revolution obtained by rotating a polygonal chain around an axis at 0.36%. The relative error of measurement reached 4.44% in sphere and around 5% in solid of revolution obtained by rotating two curves around an axis and solid of revolution obtained by rotating three curves around an axis. The relative error of volume measurements was the lowest in rotational ellipsoid (spheroid) and ellipsoid at 3.58% and 4.48%, respectively. The developed geometric models can be used in research and design.
Clinical characteristics, management, and prevention of coronavirus disease 2019
Authors: Guan Weijie , He Jianxing 
Published: August 2023

Abstract
Coronavirus disease 2019 (COVID-19) is the third severe acute respiratory disease of the 21st century and the most aggressive global pandemic to date. The whole population has been susceptible to the disease, particularly the emerging variants of the virus. The core pathophysiological mechanism is viral sepsis that can lead to the respiratory tract disorders and even systemic disorders such as cytokine release syndrome, thrombosis, abnormal angiogenesis, and multiple organ dysfunction. Despite only few licensed treatments to date, rapid advances have been made in exploring the effectiveness and safety of pharmacological interventions and vaccines. However, three pillars of preventative and control measures - proactive contact tracing, wearing facial masks, and social distancing - are essential to combat the ongoing pandemic. As the number of patients recovering from COVID-19 rapidly increases, the world has entered the era of caring for patients during the convalescence phase. This phase still represents a largely unmet medical need globally.
The impact of low ambient temperature on cardiovascular health
Authors: Zhang Guoqing , Liu Cuiqing , Sun Qinghua 
Published: August 2023

Abstract
Extreme weather events and climate change have witnessed a substantial increase in recent years, leading to heightened concerns. The rise in abnormal ambient temperatures, both in intensity and frequency, directly and indirectly impacts cardiovascular health. While the impact of high ambient temperatures on cardiovascular response is a common concern in the context of global warming, the significance of low temperatures cannot be overlooked. The challenges posed by low temperatures contribute to increased cardiovascular morbidity and mortality, posing a significant threat to global public health. This review aims to provide an overview of the relationship between low ambient temperature and cardiovascular health, encompassing the burden of cardiovascular outcomes and underlying mechanisms. Additionally, the review explores strategies for cold adaptation and cardioprotection. We posit that to optimize cold adaptation strategies, future research should delve deeper into the underlying mechanisms of cardiovascular health in response to low ambient temperature exposure.
Design, Additive Manufacturing and Testing of a Quadcopter Drone
Authors: Țura Diana-Mihaela , Zaharia Sebastian-Marian 
Published: August 2023

Abstract
In a world where technology and aviation are developing at a rapid pace, and where innovations and designs in this field are growing exponentially, drone-like aircraft has become an extremely popular topic in both the civilian and military fields in recent years. In this study, a complete development cycle of a quadcopter drone has been carried out, starting from preliminary design to flight validation of the model manufactured by additive processes. Thus, the preliminary design of the drone was performed, followed by aerodynamic and finite element analyses of the drone structure, and then the additive manufacturing of the drone components. The final steps of this study are the assembly of the drone components and the flight testing of the quadcopter drone model.
Fremde Welt: Nur eine Minderheit teilt Deutschlands „Werte“
Authors: Menkhoff Lukas 
Published: August 2023

Abstract
Countries in the world need cooperation to solve global problems, and Germany with its strongly outward-oriented economy has a particular interest in world-wide cooperation. The generally accepted human rights seem to provide a solid ground for this, but at a closer look, the area of generally shared values is much smaller. In particular, Germany with its moral concepts is not representative of the world. This applies to several values and consequently can also be seen in aggregated analyses. The number of partners sharing the same values is rare beyond Europe.
Grunderwerbsteuer: Finanzministerium plant Möglichkeit zur Abschaffung
Authors: Rasquin Christian 
Published: August 2023

Abstract
The Federal Ministry of Finance wants to allow German Federal States to lower the property transfer tax rates for owner-occupied housing. There is evidence that such tax heavily distorts the housing market. However, since the tax is an important source of revenue for the Federal States, it remains to be seen whether these will cut tax rates.