bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring the Effect of Corydalis Yanhusuo on Hepatoc ellular Carcinoma Mechanism through Network Pharma cology,Molecular docking and In Vitro Experiments
Authors: Yu Shuihong , Liu Huijuan , Jiang Tao , Wu Qiguo 
Published: June 2023

Abstract
Object: The study was conducted using network pharmacology (NP) and experimental validation as a base to identify potential targets and mechanisms of action of Corydalis yanhusuo (YHS) in treating Hepatocellular Carcinoma (HCC).
Methods: Traditional Chinese Medicine Systems Pharmacology (TCMSP) databasewas utilized to select effective YHS components, while the SymMap database was used to predict target proteins associated with effective components, and genes that could be related to HCC were selected using the GeneCards database. The Venn platform was used to obtain targets shared by YHS and HCC. Later, a String webserver was used to build protein-protein interaction (PPI) network, while a drug-component-target network was created using Cytoscape. GO and KEGG analysis was performed to parse biological processes and linked pathways connected to YHS in the treatment of HCC. Molecular docking technology was used to analyze the optimal effective components. The in vitro experiment on the HepG2 cell model confirmed the NP results.
Results: In total, 48 effective components and 88 shared targets were obtained. The main active ingredients identified were quercetin, hyndarin, isocordinine, (S)-Scoulerine, leonticine, and (R)-Canadine. The target-pathway network had 11 proteins and 211 pathways. Hub genes, in the PPI network included TP53, TNF, AKT1, MAPK1, IGF2, CDKN2A, TGFB1, MYC, CASP8, IL6, and CASP3. Moreover, as revealed by GO and KEGG analysis, Hepatitis B, the MAPK pathway, and the TNF pathway were all strongly linked to YHS's impact on HCC. Moreover, as demonstrated by in vitro experiments, YHS displayed remarkable activity in the treatment of HCC, most likely by regulating cell growth and apoptosis via MAPK pathways.
Conclusion: The present work suggests that NP-based analyses combined with experimental validation provide an efficient approach for characterizing the mechanism of YHS in the treatment of HCC.
An Analytical Economic Dynamic Model Considering Unemployment and Incorporating SIR’s Approach
Authors: Oliveira João Gabriel de Araujo , Góes Geraldo Sandoval , Teixeira Joanilio Rodolpho 
Published: June 2023

Abstract
The present paper has the objective to develop three new approaches to Macrodynamics. In the first one, we design a new model where capacity utilization is defined by the difference between population (represented by the sum of activity and unemployed labor force), and capital stock growth rates. Second, we spread unemployment into both, the natural one and the other caused by external reasons. Third, we incorporate the SIR’s (Susceptible, Infectious, or Recovered) approach into the second framework to understand how Pandemics can affect economic behavior. Then, we proved the stable condition of all three cases and also consider a numerical simulation to ensure their economic efficiency. As a result, the first model acts exactly like a post-Keynesian (neo-Kaleckian) expects it to behave (in the short and medium runs it is possible to assume unemployment, but in a long-period full employment is arrived). Despite the convergence of capacity utilization to its normal level, it seems that, in the second case, we will have a time lag of involuntary unemployment. In the third case, when the epidemiological model is considered (if, and only if, the Pandemic is the only reason for unemployment caused by external motives), the model will converge to full employment of factors like in the first case. These models serve as an inspiration to guide policymakers on how to deal with epidemiological crises and their consequences in the labor market.
JEL Classification: N1 , P36
Using evaluated AquaCrop and Response Surface Method to determine optimum irrigation water and seeding density of wheat growing in a sprinkler irrigation system
Authors: Shabani Ali , Habibagahi Majid , Mahbod Mehdi , Partojou Farhad , Mahmoudi Mohammad Reza 
Published: June 2023

Abstract
This study used AquaCrop to predict wheat grain yield under different irrigation and seeding densities. Experimental data from two successive growing seasons during 2004–2006 was used for model calibration and validation. After calibration, the model was used to predict grain yield for 47 years (1975–2021) with five seeding densities (120, 80, 160, 200, and 240 kg ha-1) and four irrigation schedules (7-, 10-, 13-, and 16-days interval). Predicted data were used to identify the optimal seeding density and irrigation water level. AquaCrop's simulations of grain yield, biomass, soil water content, evapotranspiration, and canopy cover were promising. Under extreme water stress, the model produced less reliable results. The RSM method determined the optimal seeding density and irrigation schedule to maximize crop yield and income per hectare. Results showed that 747, 198, and 747 mm of irrigation water and 211, 188, and 208 kg ha-1 of seeding density maximized wheat yield, water productivity, and profit per unit area, respectively. Additionally, 350 and 1230 mm of irrigation and rainfall and 162 and 212 kg ha-1 of seeding density were found to maximize water productivity and profit per unit area. Overall, this study demonstrates that the AquaCrop model can be used to accurately estimate wheat grain yield under different irrigation intensities and seeding densities, which can inform decisions on optimal irrigation and seeding practices for maximizing crop yield and profit.
A Case of latent Sjögren's syndrome Primary Manifested as Flaccid Quadriparesis. A First Reported Case From Libya.
Authors: Abduljalil Mohamed Muftah , Dawas Najwa Ali 
Published: June 2023

Abstract
Primary Sjögren's syndrome is an autoimmune condition characterized by lymphocytic infiltration of exocrine glands, lung, kidney, skin, gastrointestinal tract, liver, and muscle. Flaccid Quadriparesis due to renal involvement is rarely reported in the medical literature. We herein present a case report of a 42-year-old woman with acute onset motor weakness; sever hypokalemia and Distal Renal Tubular Acidosis. Patient was diagnosed with Primary Sjögren's and managed accordingly.
Investigation on structural and morphological properties of molybdenum trioxide (MoO3) thin films
Authors: kossar shahnaz , Rasool Asif 
Published: June 2023

Abstract
The present study reports on the effect of substrate temperature on structural, morphological and optical properties of MoO3 thin films. MoO3 thin films were deposited on pre-heated glass substrate using spray pyrolysis technique. The substrate temperature was varied from 300 °C to 400°C with a step interval of 50 °C. Structural studies were studied using X-ray diffraction technique. It is observed that all the diffraction peaks exactly match with JCPDS card No. 05-0508. The as –deposited MoO3 thin films exhibits orthorhombic crystal structure. It is found that the crystalline nature increases with the increases of substrate temperature. FESEM micrographs show that the grains are distributed uniformly over the surface without any void. An optical property reveals that the transmission of MoO3 thin film in the visible region increases with increases of deposition temperature.
Computed Tomography Measurement of the Aorta in Midaortic Syndrome in Children and Adolescents and Their Clinical Manifestations and Outcomes
Authors: Baek Seung-Min , Lee Yoon Seong , Song Mi Kyoung , Lee Sang Yun , Bae Eun Jung , Kim Gi Beom 
Published: June 2023

Abstract
Background
Midaortic syndrome (MAS) presents challenges in diagnosis due to the absence of well-defined diagnostic criteria, and its clinical features remain uncertain. In this retrospective study, we aimed to aid in the diagnosis of MAS by employing computed tomography (CT) to measure the z-score of the aorta as well as to identify and understand its clinical features.
Methods
CT images, echocardiography findings, and medical records of 17 patients diagnosed with MAS between 1997 and 2023 were reviewed, and z-scores were calculated. Aortic size on follow-up CT, blood pressure, and left ventricular function at the last follow-up were analyzed, and possible prognostic factors were examined.
Results
With the exception of one patient, all individuals exhibited a z-score below − 2 at the level corresponding to stenosis. Left ventricular dysfunction occurred more frequently in patients aged < 5 years (p = 0.024). Patients with idiopathic MAS showed a better prognosis in terms of blood pressure and follow-up aortic size (p = 0.051 and 0.048, respectively).
Conclusions
CT-measured aortic z-scores may be useful for the diagnosis and follow-up of MAS. A more conservative management plan should be considered for selective idiopathic patients.
Rubber-tracked forwarders – productivity and cost efficiency potentials
Authors: Lundbäck Mikael , Lindroos Ola , Servin Martin 
Published: June 2023

Abstract
Extraction of timber is expensive, energy intensive, and potentially damaging to the forest soil. Machine development aims to mitigate risks for environmental impact and decrease energy consumption while maintaining or increasing cost efficiency. Development of rubber-tracked forwarders have gained renewed interest, partly due to climate change leading to unreliable weather, and the urgency of reducing emissions. The increased cost of rubber-tracks compared to wheels are believed to be compensated by higher driving speeds and larger payloads. Thus, the aim of this study was to theoretically investigate how productivity and cost efficiency of rubber-tracked forwarders can exceed that of wheeled equivalents. The calculations were made with fixed parameters, to evaluate performance in different conditions, and with parameters from 2 500 final felling stands in central Sweden, to evaluate performance in varied working conditions. Scenarios were compared to a baseline corresponding to mid-sized wheeled forwarders. The results show higher productivity with the increased driving speed and load weight enabled by rubber-tracks at all extraction distances, with larger differences at long extraction distances. Assuming 15% higher machine price for the rubber-tracked forwarder, increased speed and load weight lead to 40% cost reduction for 400 meters extraction distance. Furthermore, a rubber-tracked forwarder is likely to give access to a larger part of the harvest areas during longer seasons. The year-round accessible volumes are estimated to increase from 9% to 92% with a rubber-tracked forwarder. With rubber-tracks, good accessibility can be combined with low soil impact in a favourable way for both industry and ecosystem.
Interest in genetic susceptibility testing and disclosure of AD dementia risk in cognitively normal adults: A survey study
Authors: Waterink Lisa , Masselink Larissa A. , Lee Sven J. van der , Visser Leonie N.C. , Cleutjens Solange , Schaar Jetske van der , Harten Argonde C. van , Scheltens Philip , Sikkes Sietske A.M. , Flier Wiesje M. van der , Zwan Marissa D. 
Published: June 2023

Abstract
BACKGROUND
Apolipoprotein-E (APOE) genetic testing for Alzheimer’s disease is becoming more important as clinical trials are increasingly targeting individuals carrying APOEε4-alleles. Little is known about the interest in finding out ones genetic risk for Alzheimer’s disease in the general population. Our objective was to examine this in a sample of cognitively normal (CN) adults within a population-based online research registry with the goal to implement APOEε4 status for trial recruitment.
METHODS
An online survey was completed by 442 CN participants between the age of 49 and 75 years (56% female) from the Dutch Brain Research Registry. The survey assessed interest in participation in research into, and disclosure of, genetic risk for dementia. The survey assessed interest in participation in research into, and disclosure of, genetic risk for dementia, and the knowing their genetic risk in different hypothetical risk scenarios (10%, 30%, and 50% genetic risk for dementia at age 85, corresponding to APOEε2/ε2 or ε2/ε3, APOEε3/ε4 or ε2ε4, and APOEε4/ε4 genotypes). Cochran’s-Q and post-hoc McNemar tests were used to analyse differences in frequencies across scenarios.
RESULTS
Most participants were interested in participating in research into and disclosure of their genetic risk (81%). The most reported reason was to contribute to scientific research (94%). Interest was higher in males, while lower-educated participants were more often undecided. When provided with different risk scenario’s, interest in knowing their risk was somewhat higher in the scenarios with higher risk, i.e., in the 50% (79%) compared to the 10% scenario (73%;χ2(2) = 7.98; p = .005). Most individuals expected they would share their genetic risk with close relatives (77–89%), would participate in medication trials (79–88%), and would make long-term arrangements e.g. retirement, health care, will (69–82%), with larger proportions for scenarios with higher hypothetical genetic risk.
CONCLUSIONS
Our findings indicate that the vast majority of CN adults participating in an research registry expresses interest in AD genetic risk research and disclosure. Interest in genetic risk disclosure is higher in scenarios corresponding to the APOEε4-genotype. This suggests APOEε4-screening within an online research registry is potentially a well-received method to accelerate inclusion for trials.
Analyzing the Effectiveness of Environmental Impact Assessment in Paraná, Brazil and California, United States With Fuzzy-set Qualitative Comparative Analysis and the Analytical Hierarchy Process
Authors: Loomis John James , Dziedzic Maurício 
Published: June 2023

Abstract
Environmental impact assessment (EIA) has become one of the most widespread environmental management instruments. Despite this, EIA is routinely criticized for being ineffective at impacting decision-making. This study compared the EIA systems of Paraná, Brazil and California, United States using the effectiveness dimensions from the EIA literature. This study formats the cases into contextual conditions using the fuzzy-set qualitative comparative analysis (fsQCA) to identify the necessary and sufficient conditions that cause effective outcomes. These effectiveness outcomes are then ranked by EIA stakeholders via the analytical hierarchy process (AHP) to identify stakeholder priorities and to improve stakeholder management. The results show that in Paraná stakeholders identified normative effectiveness as the most important dimension, while stakeholders in California identified this dimension as the second-most important following substantive effectiveness. Public participation was found to be a necessary condition for both substantive and normative effectiveness to occur. Early project definition was found to be sufficient for substantive effectiveness and necessary for normative effectiveness, for which stakeholder coordination was a sufficient condition. This suggests that in order for EIA to influence decision-making and foster sustainable development, greater care needs to be taken to actively engage stakeholders in public participation, with clear roles and project design communicated early on, and a clear role for regulatory authority to promote stakeholder coordination for acceptable outcomes. These findings suggest that some effectiveness dimensions are caused by similar conditions, which could help focus stakeholder management efforts and point to new avenues for future EIA effectiveness research.
High dietary marula (Sclerocarya birrea subsp. caffra) seed (nut) cake induces detrimental effects on performance, carcass characteristics and immuno- physiology of broiler chickens
Authors: Mthana Makiwa Simeon , Mthiyane Doctor Mziwenkosi Nhlanhla , Onwudiwe Damian Chinedu , Mwanza Mulunda 
Published: June 2023

Abstract

Background
The objective of this study was to investigate effects of dietary incremental levels of marula seed cake (MSC), partially replacing soya bean meal (SBM) on growth performance, carcass characteristics, and haemato-biochemistry of broiler chickens from starter to finisher phases. In a completely randomized design, 400 day-old Ross 308 broilers were randomly allotted to 5 diets with 0, 5, 10, 15 and 20% MSC, each with 8 replicates of 10. Weekly feed intake, body weight gain and feed conversion efficiency were calculated whilst haemato-biochemistry was measured at d42.
Results
Overall, feed intake was quadratically decreased (P < 0.01) by MSC, of which the optimum inclusion was 15%. Body weight gain and feed conversion efficiency was linearly decreased (P < 0.001 and P < 0.01, respectively) by dietary inclusion of MSC. Also, MSC linearly decreased slaughter weight (P < 0.001), hot carcass weight (P < 0.001) and cold carcass weight (P < 0.001). Similarly, it linearly decreased white blood cells (P < 0.01) and lymphocytes (P < 0.05) and symmetric dimethylarginine (P < 0.001), as it linearly increased (P < 0.001) serum cholesterol.
Conclusion
In conclusion, up to 15% MSC can be incorporated into broiler diets in replacement of SBM without adverse effects.
The refugee footprint on politics; a study on refugee influx and voting in Germany
Authors: Adee Md Iltemas Amin , Lee Grace Hooi Yean , Rahman Habib 
Published: June 2023

Abstract
Europe faced a significant refugee crisis in the last decade due to the large influx of refugees from North Africa and the Middle East fleeing war and prosecution. A daunting trend of increasing popularity of right-wing political par and rising hate crime reports is observable across Europe. This paper employs difference-in-differences (DID) regression analysis utilizing the German Socio-Economic Panel (SOEP) to investigate the effect of refugee influx on voting behavior in Germany. In addition, this paper uses nightlight data to test whether economic development moderates the relationship between refugee influx and voting behavior. The results show that voting for immigrant-friendly parties, Christian Democratic Party (CDU) and FDP (Free Democratic Party) improved in districts with substantial refugee influx; however, deteriorated for anti-immigration parties such as Social Democratic Party (SPD) and AfD (Alternative for Germany), after the refugee influx. In addition, the 2SLS results prove that larger cities with greater economic activities are more resistant to liberal parties due to prolonged economic and infrastructure scarcity or challenges. The results of this study are robust to an extensive range of tests, such as using a different measure of refugee severity, falsification tests, and placebo tests. The findings of this study would allow political parties to target and allure voters and help policymakers identify and design social interventions to improve tolerance and acceptance in the community.
Improved prediction of breast cancer risk based on phenotypic DNA damage repair capacity in peripheral blood B cells
Authors: Okunola Hazeem L. , Shuryak Igor , Repin Mikhail , Wu Hui-Chen , Santella Regina M. , Terry Mary Beth , Turner Helen C. , Brenner David J. 
Published: June 2023

Abstract
Background
Standard Breast Cancer (BC) risk prediction models based only on epidemiologic factors generally have quite poor performance, and there have been a number of risk scores proposed to improve them, such as AI-based mammographic information, polygenic risk scores and pathogenic variants. Even with these additions BC risk prediction performance is still at best moderate. In that decreased DNA repair capacity (DRC) is a major risk factor for development of cancer, we investigated the potential to improve BC risk prediction models by including a measured phenotypic DRC assay:
Methods
Using blood samples from the Breast Cancer Family Registry we assessed the performance of phenotypic markers of DRC in 46 matched pairs of individuals, one from each pair with BC (with blood drawn before BC diagnosis) and the other from controls matched by age and time since blood draw. We assessed DRC in thawed cryopreserved peripheral blood mononuclear cells (PBMCs) by measuring γ-H2AX yields (a marker for DNA double-strand breaks) at multiple times from 1 to 20 hrs after a radiation challenge. The studies were performed using surface markers to discriminate between different PBMC subtypes.
Results
The parameter Fres, the residual damage signal in PBMC B cells at 20 hrs post challenge, was the strongest predictor of breast cancer with an AUC (Area Under receiver-operator Curve) of 0.89 [95% Confidence Interval: 0.84–0.93] and a BC status prediction accuracy of 0.80. To illustrate the combined use of a phenotypic predictor with standard BC predictors, we combined Fres in B cells with age at blood draw, and found that the combination resulted in significantly greater BC predictive power (AUC of 0.97 [95% CI: 0.94–0.99]), an increase of 13 percentage points over age alone.
Conclusions
If replicated in larger studies, these results suggest that inclusion of a fingerstick-based phenotypic DRC blood test has the potential to markedly improve BC risk prediction.
MRI brain segmentation based on improved global best-guided artificial bee colony
Authors: Alomoush Waleed , Khashan Osama A. , Alrosan Ayat , Damseh Rafat , Attar Hani H. , Alshinwan Mohammad , Abd-Alrazaq Alaa Ali 
Published: June 2023

Abstract
Brain Magnetic Resonance Imaging (MRI) plays a critical role in medical research and clinical applications, ranging from quantifying tissue volume, facilitating surgical simulations, assisting in treatment planning, enabling brain mapping, aiding in disease diagnosis, and evaluating therapeutic efficacy. This study introduces a novel method for MRI brain segmentation, which harnesses the power of a hybrid approach combining Artificial Bee Colony (ABC) algorithm with Fuzzy C-Means (FCM) clustering. Our approach leverages the exploration capability of the ABC algorithm, with an improved global best guidance (IABC), to optimally initialize the cluster centroid values of the FCM, thus enhancing the segmentation outputs. Comparative evaluation of the proposed method, denoted as IABC-FCM, conducted on a diverse set of MRI brain images, reveals its superior performance. The results indicate the potential of this hybrid approach as a robust tool for improved MRI brain segmentation tasks.