bluuebunny/crossref_metadata_2025_split huggingface dataset:
RANCANG BANGUN APLIKASI EVENT DI LINGKUNGAN KAMPUS UNISKA MAB BANJARMASIN
Authors: Wijaya Yusup Indra , Rahman Muhammad Saidi , Chandra Herry Adi 
Published: January 2025

Perkembangan teknologi digital telah membawa perubahan signifikan dalam berbagai aspek kehidupan, termasuk dalam pengelolaan kegiatan di lingkungan kampus. Universitas Islam Kalimantan (UNISKA) MAB Banjarmasin menghadapi berbagai kendala dalam penyelenggaraan event kampus, seperti proses distribusi informasi yang tidak efisien, pendaftaran peserta secara manual, serta pengelolaan acara yang kurang terorganisir. Untuk mengatasi permasalahan tersebut, penelitian ini bertujuan merancang dan membangun aplikasi berbasis web yang dapat digunakan untuk mendukung pengelolaan event secara efektif dan efisien. Aplikasi ini akan dirancang dengan tiga peran utama, yaitu Mahasiswa, Panitia, dan Admin, yang masing-masing memiliki akses dan fitur yang sesuai dengan kebutuhannya. Fitur utama meliputi pendaftaran online, pengelolaan data peserta, distribusi informasi, hingga penerbitan sertifikat digital. Metode pengembangan sistem yang digunakan adalah System Development Life Cycle (SDLC) dengan tahapan analisis kebutuhan, perancangan, pengembangan, pengujian, dan pemeliharaan. Dengan adanya aplikasi berbasis web ini, diharapkan dapat memberikan solusi yang efektif dalam mengelola event di kampus. Aplikasi ini mempermudah mahasiswa dalam memperoleh informasi dan berpartisipasi dalam kegiatan, membantu panitia dalam menyelenggarakan event secara terorganisir, serta mendukung admin dalam memantau dan mengelola aktivitas kampus. Dengan implementasi aplikasi ini, diharapkan dapat meningkatkan efisiensi, transparansi, dan partisipasi dalam berbagai kegiatan yang diselenggarakan di UNISKA MAB Banjarmasin.
Potensi Ekstrak Metanol, Fraksi N-Heksana dan Etil Asetat Daun Kasturi (Mangifera Casturi Kosterm) Terhadap Aktivitasnya Sebagai Anti Bakteri
Authors: Sutomo Sutomo , Fajri Ahmad , Viogenta Pratika , Arnida Arnida , Wathan Nasrul 
Published: January 2025

Salah satu tumbuhan obat yang secara empiris memiliki aktivitas antibakteri adalah kasturi (Mangifera casturi). Tumbuhan M. casturi merupakan salah satu tumbuhan khas Kalimantan. Penelitian ini bertujuan menentukan aktivitas antibakteri ekstrak metanol, fraksi n-heksan dan fraksi etil asetat daun M. casturi terhadap bakteri Staphyloccocus aureus, Eschericia coli, dan Salmonella typhi. Metode yang digunakan pada penelitian ini yakni metode Kirby-bauer dan Bioautografi dengan konsentrasi ekstrak metanol, fraksi n-heksan dan fraksi etil asetat sebesar 5, 10, dan 15% serta kontrol positif siprofloksasin dan kontrol negatif Na-CMC 0,5%. Hasil menunjukkan bahwa diameter zona hambat ekstrak metanol, fraksi n-heksana dan fraksi etil asetat secara berurutan didapat 14,4; 9,21; dan 14,63 mm pada bakteri St. aureus, 14,43; 16,01; dan 17,21 mm pada bakteri E. coli serta 10,23; 8,4; dan 12,21 mm pada bakteri S. typhi. Hasil KLT-Bioautografi dengan eluen n-heksana : etil asetat (5:5)v/v pada fraksi etil asetat dengan Rf 0,45 terdapat zona hambat terhadap S. typhi. Hasil analisis menunjukkan bahwa pemberian perlakuan ekstrak metanol, fraksi n-heksana dan fraksi etil asetat pada konsentrasi 5, 10, dan 15% berbeda signifikan terhadap kontrol negatif dan positifnya. Fraksi etil asetat daun M. casturi merupakan hasil yang terbaik dalam menghambat bakteri St. aureus, E. coli dan S. typhi. Dengan demikian dapat dikatakan bahwa daun tumbuhan M. casturi berpotensi dalam menghambat pertumbuhan bakteri.
Analisis Faktor Lingkungan yang Berhubungan dengan Kejadian Diare pada Balita di Wiliayah Kerja Puskesmas Pahandut Kota Palangka Raya
Authors: Arif Ahmad , Lestari Rizki Muji , Baringbing Eva Prilelli 
Published: January 2025

Latar Belakang Penyakit diare masih merupakan masalah kesehatan dan penyebab kematian pada balita. Faktor lingkungan yang kurang mendukung dapat menyebabkan tingginya angka kejadian diare. Tujuan Penelitian ini untuk mengetahui faktor lingkungan yang berhubungan dengan kejadian diare pada balita di wilayah kerja puskesmas pahandut. Metode Penelitian yang digunakan adalah Total Sampling. Desain penelitian ini mengunakan survey analitik dengan pendekatan Cross Sectional. Sampel penelitian sebanyak 53 orang ibu yang berkunjung ke Puskesmas Pahandut. Data penelitian ini di ambil dengan menggunakan kuesioner setelah di tabulasi data di analisis secara univariat dan analisis bivariat dengan menggunakan uji Chi-squere. Hasil Berdasarkan uji chi-square dengan sotfware SPSS 16, di peroleh hasil faktor sumber air bersih dengan nilai p = 0,046 < = 0,05. Faktor jenis tempat pembuangan tinja dengan nilai p = 0,003 < = 0,05, dan faktor sarana pembuangan sampah dengan nilai p = 0,091 > α 0,05). Kesimpulan Ada hubungan yang signifikansi antara sumber air bersih dengan kejadian diare, ada hubungan yang signifikasi antara jenis sarana pembuangan tinja dengan kejadian diare, tidak ada hubungan yang signifikasi antara sarana pembuangan sampah dengan kejadian diare.
Studi Kasus Anemia Sedang pada Kehamilan Trimester III dengan Terapi Non Farmakologi Konsumsi Buah Pisang Ambon (Musa Paradisiaca Var Sapientum Linn) di Daerah Aliran Sungai (DAS) Kota Palangka Raya Tahin 2024
Authors: Hertati Dessy , Pratiwi Ana Paramita , Tarnoto Tenny 
Published: January 2025

Latar Belakang: Anemia menjadi penyebab kematian selama kehamilan yang berkontribusi sebesar 20-40%. World Health Organization (WHO) 2017 mendefinisikan anemia pada kehamilan dengan kadar hemoglobin (Hb) < 11g/dl pada trimester I dan III atau < 10,5 g/dl pada trimester II. Anemia dapat meningkatkan risiko kematian janin selama periode prenatal, bayi lahir sebelum waktunya, risiko perdarahan postpartum, hipertensi dan gagal jantung saat kehamilan, Berat Badan Lahir Rendah. Tujuan: Mampu memberikan Asuhan Kebidanan Kehamilan Fisiologis pada Ny. P G1P0A0 hamil 30 minggu dengan masalah anemia sedang di Ruang KIA UPTD Puskesmas Pahandut Kota Palangka Raya. Metodologi: Jenis penelitian yang digunakan yaitu secara kualitatif deskriptif dengan metode pendekatan studi kasus. Desain menggunakan observasional lapangan. Metode pengumpulan data dengan cara wawancara, dan analisis dokumentasi asuhan kebidanan. Analisis data diperoleh dari penelitian studi kasus dengan membuat narasi dari hasil observasi dan deskripsi analisis asuhan kebidanan, pengkajian, merumuskan diagnose kebidanan, merencanakan, melaksanakan, dan melakukan evaluasi asuhan kebidanan. Penelitian ini dilakukan pada bulan November 2023. Hasil: ibu bersedia untuk mencoba pengobatan alternative terapi non farmakologi/komplementer untuk mengatasi anemia sedang pada ibu yaitu dengan mengkonsumsi 2 buah pisang ambon sehari selama 14 hari karena pisang ambon juga banyak mengandung zat besi dan juga vitamin C untuk penyerapan zat besi serta berperan dalam pembentukan hemoglobin sehingga mempercepat penyembuhan penyakit anemia. Vitamin C juga berperan dalam mentransfer zat besi dari transferin dalam plasma ke feritin hati. Pisang juga banyak mengandung asam folat atau vitamin B6 yang larut dalam air, yang diperlukan untuk membuat asam nukleat dan hemoglobin dalam sel darah merah.
Penerapan Asuhan Kebidanan Komprehensif pada Ny. I Usia 22 Tahun G1P0A0 Hamil Trimester Tiga dengan Gangguan Kesehatan Mnetal di Puskesmas Timpah Kecamatan Timpah Kabupaten Kapuas
Authors: Kumala Desi , Araya Wenna , Lelia Berti 
Published: January 2025

Latar belakang: Wanita yang sedang hamil membutuhkan perawatan dan dukungan keluarga yang lebih besar, tanpa dukungan tersebut mereka lebih mungkin mengalami stress prenatal (Xian, Zhuo, Dihui, & Xiaoni, 2019). Dampak yang dapat ditimbulkan dari masalah tersebut meliputi Dampak terhadap bayi adalah risiko lahir prematur atau berat badan lahir rendah (BBLR) yang berisiko besar terjadinya masalah kesehatan yang lain. Tujuan penelitian: Memberikan asuhan kebidanan secara komprehensif yang dimulai dari hamil dengan gangguan kesehatan mental pada Ny.I di Puskesmas Timpah Kabupaten Kapuas dengan menggunakan pendekatan manajemen kebidanan. Metode : Desain Penelitian menggunakan case study. Adapun studi kasus dalam penelitian bertujuan menganalisis dalam penerapan pemberian asuhan kebidanan komprehensif kepada Ny. I yang diberikan asuhan sejak masa kehamilan, persalinan, nifas, bayi baru lahir sampai keluarga berencana serta factor-faktor yang mempengaruhi. Data primer hasil wawancara dan observasi langsung. Data sekunder dari buku Register,buku KIA, dan rekam medik UPT Puskesmas Timpah Kabupaten Kapuas. Hasil: Asuhan kebidanan kehamilan Ny.I usia 22 tahun G1 P0 A0 dengan gangguan kesehatan mental, ANC dilakukan sebanyak 4 kali kunjungan, persalinan berjalan normal, bayi lahir normal, nifas dan pelayanan keluarga berencana berjalan lancar. Kesimpulan: Penerapan Asuhan kebidanan komprehensif pada Ny. I Usia 22 tahun di UPT Puskesmas Timpah Kabupaten Kapuas berjalan dengan lancar walaupun dengan gangguan kesehatan mental dengan bantuan dan kerjasama dengan keluarga dapat dilakukan sesuai standar pelayanan. Kondisi bayi mengalami gangguan kejang pada bayi dapat segera mendapat pertolongan pertama di tempat rujukan. Asuhan yang diberikan sesuai dengan standar pelayanan asuhan kebidanan dan dibuat dalam pendokumentasian.
BIMBINGAN DAN PENYULUHAN TENTANG PENTINGNYA MEMBANGUN LOYALITAS PELANGGAN PADA KELOMPOK USAHA JAMAAH MASJID AL IKHLAS RT.07, RW.17, SUDIMORO,MOJOLANGU KEC.LOWOKWARU KOTA MALANG
Authors: Samboro Joko , Maskan M , Utomo Heru , Helmy Abdullah , Afandi Yosi , Hadi Musthofa 
Published: January 2025

The purpose of this PKM is to find the problems faced by the congregation of the AL Ikhlas Mosque RT.076 RW.17 Sudimoro, Mojolangu Village, Lowokwaru District, Malang City and at the same time provide the right solution to achieve increased knowledge and skills in the field of marketing management, especially building customer loyalty. The methods used are: observation, to observe activities carried out both in the economic and socio-religious fields, then interviews, explored to find problems and solutions that will be offered and simulations, to find the most appropriate alternatives to market goods more effectively. Description of the technology to be applied. 1. In the form of lectures: Study Group participants are gathered in a certain room and given a lecture on devotion material in the form of: Customer Loyalty. 2. Guidance and Training: In the form of practical guidance and training and discussion of experiences and obstacles in the field. 3. Simulation practice: In the form of a demonstration of how entrepreneurs offer goods, and how to attract potential consumers, until loyal customers are formed

Keywords: guidance and counseling, customer loyalty.
Implementasi Infrastruktur Jaringan Untuk Mendukung Program Sertifikasi SMA Islam Kepanjen Kabupaten Malang
Authors: Ariyanto Yuri , Syaifudin Yan Watequlis , Harijanto Budi , Puspitasari Dwi , Setiadi Chandrasena , Astiningrum Mungki 
Published: January 2025

The Community Service Program intends to support the Empowering School Certification Program by establishing computer network infrastructure at the Islamic High School in Malang's Kepanjen region. According to analysis studies, the current network falls short of the online access criteria for certification tests. This intervention employed two essential approaches. The first option entails installing standard-based computer networks in the school laboratory facilities. The second option gives information technology (IT) educators extensive network management support. The Community Service Program Team of the State Polytechnic of Malang runs the initiative, which focuses on creating a reliable network topology and increasing the skills of the school's IT staff. This intervention is expected to increase overall educational quality and develop network infrastructure that will allow certification programs to be implemented. The accompanying seeks to provide expertise to Kepanjen's Islamic High School Team so that they can manage the network more independently. This community service project is designed to optimize the digital learning ecosystem, improve education and evaluation processes, and prepare students for the complexities of the digital age. This will be accomplished through collaboration between the Community Service Program team and the Islamic High School of Kepanjen District Malang.
PENDAMPINGAN INTERNET MARKETING DALAM MENDUKUNG KEGIATAN PROMOSI PADA UMKM JASMINE COLLECTION KEL. TANJUNG REJO KEC. SUKUN KOTA MALANG
Authors: Utomo Heru , Maskan Mohammad , Samboro Joko , Khabibah Umi , Indrianti Titien , Sudjanarti Dwi 
Published: January 2025

competitiveness in order to survive, continue to run and even be able to develop. For this purpose, one strategy that can be done in managing their business is to apply internet-based information technology as a support in various processes of their business activities. Internet marketing is a marketing activity with the application of information technology, which includes activities to promote products and/or services through the internet. Jasmine Collection Kel. Tanjung Rejo, Sukun District, Malang City, one of the newly developing MSMEs, has not been optimal in implementing online marketing which is part of Internet marketing. Online marketing has been carried out through private Whatsapp and Instagram statuses. This PKM activity aims to help Jasmine Collection MSMEs maximize online marketing activities. The results of this activity are in the form of logos, ebooklets, ebrochures, and videos that will be uploaded to the MSME Instagram, and the website with the address https://jasminedaster2023.blogspot.com/
PENGENALAN MICROSOFT OFFICE DI TK DHARMA WANITA TUNGLUR BADAS KABUPATEN KEDIRI
Authors: Sumarno Agus Sukoco Heru , Mandayatma Eka , Saukani Imam , Radianto Donny , Pracoyo Agus , Azhar Gilang Al 
Published: January 2025

Integrated Primary Education (TK Dharma Wanita) is a basic educational activity organized by and with the help of primary education officers. So, TK Dharma Wanita is a community initiative in the field of basic education, in which the village head is the responsible party. AA Gde Muninjaya (2002:169) states:“Basic education services are a form of integrated basic education services provided in primary education. Nowadays, computers are the tools used to process and create work reports, whether in the form of Word, Excel or PowerPoint data. Up to now, TK Dharma Wanita, headquartered in Sumberejo Badas Pare Village, Kediri Regency, still uses a conventional manual typewriter for reporting, which leads to many limitations that TK faces in terms of administrative operations. and data management.
Machine learning and molecular dynamics simulations predict potential TGR5 agonists for type 2 diabetes treatment
Authors: Enejoh Ojochenemi A. , Okonkwo Chinelo H. , Nortey Hector , Kemiki Olalekan A. , Moses Ainembabazi , Mbaoji Florence N. , Yusuf Abdulrazak S. , Awe Olaitan I. 
Published: January 2025

IntroductionTreatment of type 2 diabetes (T2D) remains a significant challenge because of its multifactorial nature and complex metabolic pathways. There is growing interest in finding new therapeutic targets that could lead to safer and more effective treatment options. Takeda G protein-coupled receptor 5 (TGR5) is a promising antidiabetic target that plays a key role in metabolic regulation, especially in glucose homeostasis and energy expenditure. TGR5 agonists are attractive candidates for T2D therapy because of their ability to improve glycemic control. This study used machine learning-based models (ML), molecular docking (MD), and molecular dynamics simulations (MDS) to explore novel small molecules as potential TGR5 agonists.MethodsBioactivity data for known TGR5 agonists were obtained from the ChEMBL database. The dataset was cleaned and molecular descriptors based on Lipinski’s rule of five were selected as input features for the ML model, which was built using the Random Forest algorithm. The optimized ML model was used to screen the COCONUT database and predict potential TGR5 agonists based on their molecular features. 6,656 compounds predicted from the COCONUT database were docked within the active site of TGR5 to calculate their binding energies. The four top-scoring compounds with the lowest binding energies were selected and their activities were compared to those of the co-crystallized ligand. A 100 ns MDS was used to assess the binding stability of the compounds to TGR5.ResultsMolecular docking results showed that the lead compounds had a stronger affinity for TGR5 than the cocrystallized ligand. MDS revealed that the lead compounds were stable within the TGR5 binding pocket.DiscussionThe combination of ML, MD, and MDS provides a powerful approach for predicting new TGR5 agonists that can be optimised for T2D treatment.
A family with normal sperm motility carrying a sY86 deletion in AZFa region and partial deletion in AZFc region
Authors: Zhao Yuhong , Zhi Weiwei , Xiong Dongsheng , Li Ningjing , Du Xinrong , Zeng Jiuzhi , Zhang Guohui , Liu Weixin 
Published: January 2025

IntroductionUsually, patients with sY84 or sY86 deficiency present with azoospermia, but recent studies have shown that some males with partial AZFa deletions, including sY84 or sY86, exhibit normal fertility. Here, we reported a rare case of AZF deletion in a family, where both father and son exhibited a deletion at the sY86 site in the AZFa region and a partial deletion in the AZFc region.Methods and ResultsDetection was performed using classical multiplex polymerase chain reaction and the “Male AZF Full-region Detection” Panel, revealing specific deletions in AZFa: Yq11.21 (14,607,372–14,637,973), 30.6 kb; AZFc: Yq11.223–11.23 (25,848,831–27,120,665), 1.3 M for the father; and Yq11.223–11.23 (25,505,378–27,120,665), 1.6 M for the son. Notably, although the son’s sperm motility parameters showed no significant abnormalities, there was a history of failed pregnancies for twice, with sperm exhibiting a high rate of head defect.DiscussionGiven the complexities of the reproductive phenotype following AZF region deletions, additional extended genetic testing is necessary when partial deletions in the AZF region are detected, thus providing more accurate predictions of the spermatogenesis in patient. This study provides valuable insights and guidance for clinical decision-making and the implementation of assisted reproductive technologies in such cases.
Gualou Guizhi Granule inhibits microglia-mediated neuroinflammation to protect against neuronal apoptosis in vitro and in vivo
Authors: Li Xuezhen , Huang Han , Li Yanan , Feng Yi , Wang Jinxuan , Luo Shuping , Chen Yaping , Zhang Yuqin , Yan Guohong , Nan Lihong 
Published: January 2025

ObjectNeuroinflammation mediated by microglia has emerged as a critical factor in ischemic stroke and neuronal damage. Gualou Guizhi Granule (GLGZG) has been shown to suppress inflammation in lipopolysaccharide (LPS)-activated microglia, though the underlying mechanisms and its protective effects against neuronal apoptosis remain unclear. This study aims to investigate how GLGZG regulates the Notch signaling pathway in microglia to reduce neuroinflammation and protect neurons from apoptosis.MethodUsing in vitro and in vivo models, we explored GLGZG's impact on microglia activation, pro-inflammatory cytokines, and neuronal apoptosis. Microglial cells were activated with LPS, and primary neuronal cells were exposed to LPS-activated microglia to simulate neuroinflammation. Additionally, we investigated the effects of GLGZG in combination with N-[N-[3,5-difluorophenacetyl]-L-alanyl]-S-phenylglycine t-butyl ester (DAPT) or siRNA-Notch1 to further elucidate the involvement of the Notch signaling pathway.ResultsGLGZG significantly inhibited microglia activation and reduced neuroinflammation by de-creasing the levels of pro-inflammatory cytokines IL-1β, IL-6, and TNF-α in both in vitro and in vivo models. GLGZG also effectively protected against microglia-induced neuronal apoptosis. Mechanistically, GLGZG down-regulated key components of the Notch signaling pathway, in-cluding Notch-1, NICD, RBPSUH, and Hes-1, in activated microglia. Combined treatment with GLGZG and DAPT or siRNA-Notch1 demonstrated enhanced inhibition of microglial activation and neuroinflammation.ConclusionOur findings reveal that GLGZG exerts its protective effects through the suppression of the Notch signaling pathway, thereby inhibiting microglia activation, reducing neuroinflammation, and safeguarding neurons from neuroinflammation-induced damage, offering potential as a therapeutic agent for ischemic stroke-induced neuroinflammation.
Novel silver nanoparticle-based biomaterials for combating Klebsiella pneumoniae biofilms
Authors: Elashkar Eslam , Alfaraj Rihaf , El-Borady Ola M. , Amer Mahmoud M. , Algammal Abdelazeem M. , El-Demerdash Azza S. 
Published: January 2025

BackgroundKlebsiella pneumoniae is a significant nosocomial pathogen that has developed resistance to multiple antibiotics, often forming biofilms that enhance its virulence. This study investigated the efficacy of a novel nanoformulation, AgNPs@chitosan-NaF, in combating K. pneumoniae biofilms.MethodsAntimicrobial susceptibility testing was performed to assess the antibiotic resistance profile of K. pneumoniae isolates. The antibiofilm activity of AgNPs@chitosan-NaF was evaluated using crystal violet staining and scanning electron microscopy. The underlying mechanisms of action were investigated through gene expression analysis.ResultsThe majority of K. pneumoniae isolates exhibited high levels of multidrug resistance. AgNPs@chitosan-NaF demonstrated superior biofilm inhibition compared to AgNPs@chitosan, significantly reducing biofilm biomass and disrupting biofilm architecture at MICs ranging from 0.125 to 1 μg/mL. Mechanistic studies revealed that the nanoformulation downregulated the expression of key biofilm-associated genes, including treC, fimA, mrkA, and ecpA. While AgNPs@chitosan-NaF exhibited a concentration-dependent cytotoxic effect on both normal and cancer cell lines, minimal cytotoxicity was observed at concentrations below 31.25 μg/mL.ConclusionThis study highlights the synergistic effect of silver nanoparticles, chitosan, and sodium fluoride in combating K. pneumoniae biofilms. The nanoformulation, AgNPs@chitosan-NaF, emerges as a promising therapeutic strategy to address the challenge of multidrug-resistant bacterial infections.