bluuebunny/crossref_metadata_2025_split huggingface dataset:
The First Genome from the Basal Monocot Family Has Been Misnamed: Taxonomic Identity of Acorus tatarinowii (Acoraceae), a Source of Numerous Chemical Compounds of Pharmaceutical Importance
Authors: Sokoloff Dmitry D. , Remizowa Margarita V. , Nuraliev Maxim S. , Averyanov Leonid V. , Sennikov Alexander N. 
Published: January 2023

The basalmost monocot genus Acorus is well-known for its use in traditional oriental medicine. It comprises the groups of A. calamus and A. gramineus. A recent study recognized three species in the latter group, A. gramineus, A. macrospadiceus, and A. tatarinowii. The material currently known as A. tatarinowii has been extensively studied as a source of various chemical compounds and for producing the first published genome of Acorus, which is important for understanding the origin and evolution of monocots. Using the data from morphology, anatomy, and biogeography, we argue that the type material of A. tatarinowii does not match the interpretation of the species name as adopted in the current literature and herbarium collections (to a taxon of the A. gramineus group from Southeast Asia) but rather belongs to the A. calamus group. Moreover, the name A. macrospadiceus also cannot be used because it was invalidly published. Under a narrow species concept, other appropriate species names should be found or proposed for the plants currently named A. tatarinowii and A. macrospadiceus. However, we discourage the use of a narrow species concept in the A. gramineus group as insufficiently justified and suggest recognizing a single polymorphic species, A. gramineus s.l., at least until a comprehensive taxonomic revision of the group is available. Apart from the presentation of our revised taxonomic framework, we update the geographical distributions of Acorus species in Vietnam, Laos, and Thailand.
Immunomodulatory Effects of Cinnamaldehyde in Staphylococcus aureus-Infected Wounds
Authors: Figueiredo Cristiane Santos Silva e Silva , Oliveira Patrícia Vieira de , Saminez Warlison Felipe da Silva , Diniz Roseana Muniz , Mendonça Juliana Silva Pereira , Silva Lucas dos Santos , Paiva Miria Yasmim Miranda , Nascimento Mayara de Santana do , Aliança Amanda Silva dos Santos , Zagmignan Adrielle , Rodrigues João Francisco Silva , Souza Joicy Cortêz de Sá , Grisotto Marcos Augusto Grigolin , Silva Luís Cláudio Nascimento da 
Published: January 2023

Cinnamaldehyde (CNM) is an essential-oil component with reported anti-infective, anti-inflammatory, and healing effects, making it an interesting compound for the treatment of wound infection. Herein, we evaluated the effects of topical administration of CNM in experimental wounds infected by Staphylococcus aureus. Swiss mice (n = 12/group) were randomly allocated into three groups (CON: animals with uninfected lesions; Sa: animals with untreated infected lesions; Sa + CNM: animals with infected wounds and treated with CNM). Excisional lesions (64 mm2) were induced at the dorsal area followed by the addition of S. aureus (80 μL of a 1.5 × 108 CFU/mL bacterial suspension). The wounds were treated with CNM (200 μg/wound/day) or vehicle (2% DMSO) for 10 days. Skin samples were taken on the 3rd or 10th treatment day for quantification of inflammatory mediators, bacterial load, immunophenotyping, and histological analysis. The treatment with CNM improved the healing process and attenuated the severity of skin lesions infected by S. aureus. These effects were associated with significant decreases in bacterial loads in CNM-treated wounds. The levels of neutrophils, TNF-α, IL-6, NO, and VEGF were decreased in the lesions treated with CNM. Taken together, these data provide further evidence of the effectiveness of CNM for the treatment of skin infections.
Polyphenolic Profile of Herniaria hemistemon Aerial Parts Extract and Assessment of Its Anti-Cryptosporidiosis in a Murine Model: In Silico Supported In Vivo Study
Authors: Ghareeb Mosad A. , Sobeh Mansour , Aboushousha Tarek , Esmat Marwa , Mohammed Hala Sh. , El-Wakil Eman S. 
Published: January 2023

Herniaria hemistemon J.Gay is widely used in folk medicine to treat hernia. The present study aimed to annotate the phytoconstituents of H. hemistemon aerial-part extract and investigate its in vivo anticryptosporidial activity. The chemical characterization was achieved via the LC–ESI–MS/MS technique resulting in the annotation of 37 phytocompounds comprising flavonoids and phenolic acids. Regarding the anticryptosporidial activity, fifty dexamethasone-immunosuppressed mice were separated into five groups: GI, un-infected (normal control); GII, infected but not treated (model); GIII, infected and received NTZ, the reference drug; GIV, infected and received H. hemistemon extract (100 mg/kg); and GV, infected and received H. hemistemon extract (200 mg/kg). When GIII, GIV, and GV were compared to GII, parasitological analyses displayed highly significant differences in the mean numbers of Cryptosporidium parvum oocysts in the stool between the different groups. GV demonstrated the highest efficacy of 79%. Histopathological analyses displayed improvement in the small intestine and liver pathology in the treated groups (GIII, IV, and V) related to the model (GII), with GV showing the highest efficacy. Moreover, the docking-based study tentatively highlighted the potential of benzoic acid derivatives as lactate dehydrogenase inhibitors. The docked compounds showed the same binding interactions as oxamic acid, where they established H-bond interactions with ARG-109, ASN-140, ASP-168, ARG-171, and HIS-195. To sum up, H. hemistemon is a promising natural therapeutic agent for cryptosporidiosis.
Comportamento suicida entre acadêmicos de medicina
Authors: Alves Vitória Silva , Ramos Thayane Beatriz Ignacio , Andrade Isadora Fernandes , Borges Gabriel França , Borges Layla Garcia , dos Santos Maria Eduarda Dantas , Guimarães Neto Armante Campos , Silva Vanessa Resende Sousa 
Published: January 2023

Introdução: O suicídio é um evento de autoextermínio que apresenta grande influência de fatores biológicos, ambientais e psicossociais para a sua concretização. É um problema de saúde pública, tendo em vista as altas taxas registradas nas últimas décadas, em especial, as observadas entre profissionais da saúde, jovens e acadêmicos - nesse último grupo destaca-se os estudantes do curso de medicina. Objetivo: Correlacionar a tríade ideação, planejamento e tentativas de suicídio com fatores de risco e de proteção da saúde mental entre acadêmicos de medicina do Centro Universitário de Mineiros. Método: Recorte de um estudo observacional e transversal com aplicação dos instrumentos realizados para análise dos fatores associados à depressão e ansiedade em acadêmicos de medicina. Participaram 244 acadêmicos de Medicina que responderam a um questionário sociodemográfico, a Escala de Ansiedade, Depressão e Stress (EADS-21) e o Inventário de Depressão de Beck (BDI–II) no ano de 2021. Resultados e Discussão: Destaca-se, os transtornos depressivos como os principais fatores para o adoecimento psíquico, e, associados ao curso de medicina, são fatores de risco o suicídio entre acadêmicos deste curso. Entretanto, esses transtornos foram, também, apontados como fatores de risco entre jovens antes mesmo de ingressar em uma escola médica. Considerações: Os fatores de risco enfrentados ao longo do curso de medicina associados ao adoecimento psíquico são desencadeadores de suicídio entre os estudantes deste curso, assim, redes de apoio são imprescindíveis para evitar o fim trágico de um jovem.
Bioprospecção da atividade antifúngica <em>in vitro</em> de plantas medicinais para preparo de forma farmacêutica de uso tópico
Authors: Fonsêca Fernanda da Silva Santos , De Oliveira Vania Jesus dos Santos , Kotwiski Fabiana Olena 
Published: January 2023

O objetivo deste artigo foi analisar a atividade antifúngica de plantas medicinais para obtenção de uma formulação de uso tópico. Trata-se de um estudo experimental com abordagem quantitativa. A identificação da planta medicinal foi realizada a partir de leitura em literaturas especializadas e concomitante a isto estivesse presente na lista da Relação Nacional de Plantas Medicinais de Interesse ao Sistema Único de Saúde. Após a coleta da espécie, foram preparados extratos aquosos em diferentes concentrações no laboratório de microbiologia da Faculdade Maria Milza - BA. Após o período de incubação de 24 horas, as placas foram analisadas quanto ao crescimento de microrganismos; logo foi realizado o teste estatístico ANOVA, para verificar diferença significativa entre as médias e se os fatores exerciam influência em alguma variável dependente bem como realizou-se análise de regressão ao nível de 5% de significância, e assim identificou-se que para a espécie E. uniflora notou-se que não houve crescimento fúngico nas concentrações testadas. Optou-se então por propor o desenvolvimento da forma a partir do extrato da espécie de E. uniflora. E foi então preparado uma fórmula com o extrato avaliando os aspectos organolépticos e para a caracterização físico-química foram determinados pH, densidade, viscosidade e o índice de espuma. Nisso o sabonete então proposto apresentou pH 6,3 ± 0,526 densidade de 0,98 e viscosidade de 23,3 ± 0,698, seu índice de espuma apresentou-se consistente 9,2 ± 0,236, quanto a análise microbiológica, obteve como resposta a ausência de crescimento fúngico nas repetições contendo a fórmula do sabonete com o extrato da E. uniflora. Nesse ínterim, considera-se que a forma farmacêutica proposta se apresenta com um potencial promissor de atividade antifúngica, podendo ser objeto de cuidado alternativo contra a candidíase na região íntima feminina.
Influência da técnica de quebra de dormência, substrato e tamanho da semente na germinação do taperebá procedentes de duas populações nativas da Amazônia Central
Authors: Azevedo Laiane Lima , Azevedo Ramon Lima , Ferreira João Cléber Cavalcante , Aoki Rafaelle Batista , De Souza Pablo Vieira , Cunha Joana Cristian Maciel , De Souza José Camilo Ramos , Ramos Santiago Linorio Ferreyra 
Published: January 2023

Spondias mombin (taperebá) é uma espécie frutífera da Amazônia, com grande potencial de uso agroindustrial e consumo “in natura”. No entanto, alguns problemas fitotécnicos persistem, dentre os quais a germinação irregular e sua má distribuição ao longo do tempo. Neste sentido, avaliamos a influência da técnica de quebra de dormência, substrato e tamanho da semente na germinação do taperebá procedentes de duas populações nativas da Amazônia Central. O estudo foi desenvolvido em casa de vegetação no Instituto de Ciências Exatas e Tecnologia (ICET) – UFAM, no município de Itacoatiara, Amazonas. A amostragem dos frutos foi realizada em duas localidades distintas de populações nativas. De cada local de amostragem utilizamos 100 frutos, sendo divididos em quatro amostras para realizar a caracterização morfoagronômica, determinando o peso, diâmetro, comprimento do fruto, peso da casca sem polpa, porcentagem de polpa, teor de umidade, diâmetro da semente, comprimento e peso da semente. Foi utilizado o delineamento experimental em blocos casualizados em esquema fatorial 4x2x2, totalizando 16 tratamentos por local de coleta. Os fatores estudados foram, quebra de dormência (corte distal, temperatura à 100oC/5 minutos, temperatura à 50oC/5 minutos, testemunha), substrato (areia e terra da mata + esterco + cinza) e tamanho do endocarpo (grande e pequeno). Os resultados demonstraram que as sementes de taperebá podem ser influenciadas pelos locais de procedências, afetando as variáveis de emergência, velocidade e o tempo médio de emergência.
Forecasting the Value of Oil and Gas Exports in Indonesia using ARIMA Box-Jenkins
Authors: Ahmar Ansari Saleh , Botto-Tobar Miguel , Rahman Abdul , Hidayat Rahmat 
Published: January 2023

The objective of the study was to forecast the value of oil and gas exports in Indonesia using the ARIMA Box-Jenkins. With this prediction, it is hoped that it can be a study for future policy making. This oil and gas export data is obtained from the Indonesian Central Bureau of Statistics (BPS) website, in raw data from January 2010 to March 2022. This data is predicted using the ARIMA method with the help of R software. The stages of data analysis with ARIMA include: data stationary test, build the model indication, parameter estimation and significance test, and residual diagnostic test of the model. The results of data analysis conducted in this study show that there are 3 indications of models that were generated, namely ARIMA(1,1,0); ARIMA(0,1,1); and ARIMA(1,1,0). From these 3 model indications, the best model was ARIMA(0,1,1) with AIC value of 2047.65.
Crosslinguistic differences on the Present Perfect Puzzle: An experimental approach
Authors: Fuchs Martín , Van der Klis Martijn 
Published: January 2023

In this paper, we analyze how different temporal and referential properties of past-referring adverbials – specifically, hodiernality and deixis – are partially responsible for the crosslinguistic distribution of PAST and PERFECT markers across Dutch, Spanish, and English. To that end, we conducted an acceptability judgment task, where 160 subjects per language rated context-sentence pairs that display either a PAST or a PERFECT marker, and a temporal adverbial that is: (i) either temporally close to or temporally far from the speech time, and (ii), either deictic or not deictic. Results show that: (a) Dutch allows for its PERFECT marker to combine with any past-referring temporal adverbial, (b) Spanish only allows its PERFECT marker to combine with adverbials that locate the event temporally close to speech time, regardless of deixis, and (iii) that English prefers its PAST marker in all past-referring situations, but allows its PERFECT to combine with adverbials that are both deictic and temporally close to speech time, particularly when the adverb specifies an interval that is included in the day of utterance (e.g., this morning), as opposed to adverbs that describe an interval that includes it (e.g., this month).
On a concessive reading of the rise-fall-rise contour: contextual and semantic factors
Authors: Göbel Alexander , Wagner Michael 
Published: January 2023

This paper presents three auditory rating experiments on the rise-fall-rise contour (RFR). Experiment 1 provides experimental evidence that the RFR makes disagreeing with a prior statement more natural than neutral intonation would. Additionally, the data show that the RFR exhibits a valence asymmetry, noted by Göbel (2019): the amelioration of a disagreement is greater when the RFR is used in a positive reply to a negative statement than in a negative reply to a positive statement. Experiments 2 and 3 investigate factors contributing to this asymmetry, showing that it disappears in replies to questions and is weakened when the reply contains an additive particle. Based on these results, we argue that the RFR has a scalar meaning, following Göbel (2019), with the relevant scale being contextually determined and resulting in an ambiguity resembling the Focus-particle at least.
On the interpretation of German <em>einige</em>. The effect of tense and cardinality
Authors: Cortez Espinoza Maya , Fricke Lea 
Published: January 2023

We present a study investigating the effect of tense (past vs. future) on the computation of scalar implicatures in connection with the German quantifier einige ‘some’ in an interactive experiment, which included a financial incentive for participants to consider whether another speaker would share their judgment. We tested the hypothesis that scalar implicatures are less frequently drawn in future tense than in past tense. In addition, we studied to what extent sets with various cardinalities are prototypical representatives of einige + N. We hypothesized that larger cardinalities are more prototypical representatives of the quantifier einige than smaller cardinalities (relative to the cardinality of the total set). We analyzed the experimental data with probabilistic Bayesian models with a linking hypothesis between participants’ responses and readings based on utility maximization in simple decision problems. In line with the hypotheses, we found that less scalar implicatures are drawn in future tense than in past tense, which replicates the results of previous research on English some, and that with an increase in set size acceptance of statements involving einige also increases.
Quantifying the Historical Development of Abugadaf Natural Forest Using GIS-Remote Sensing Analytical Techniques/ Blue Nile State/Sudan
Authors: Osman El Mamoun Haroun , Hamed Abass Mohamed Elhag , Kursi Samia Mohamed Haroun 
Published: January 2023

The main objective of this research is to provide current information about the growth and general status of Abugadaf natural forest reserve in Blue Nile State, Sudan, and to identify the possible agents and factors that contributed to the current forest status whether positive or negative. The secondary objective of the study is assess and demonstrate the capabilities of RS and GIS analytical tools in addressing the issue of monitoring and assessing natural forest areas in Sudan. Four satellite images covering the period1990, 2000, 2010 and 2018 were selected from cloud-free Land-Sat (TM, ETM and Land-Sat 8) covering the study area. All images were false color composite (FCC). Images 1990 and 2000 were thematic mapper (TM), while Image 2010 was enhanced Thematic Mapper (ETM), and image 2018 was Land-sat 8. Land-sat 8 was used as a base to assess the change detection, and GPS data used to extracts topographic information in the study areaThe tentative locations of the Land cover and land use sites were selected using image analysis aided by actual ground surveying. GPS (Garmin 62C) was used to navigate among check samples and to record the coordinates (X, Y and Z values) of all samples. The total number of samples covering the study area were 144 (800 x 400 m). The recorded data in each sample include tree species, regeneration, grass type, tree stumps, dead trees, density of survival trees, diameter at breast height, and total tree height. All training sites were utilized in the generation of signatures required for supervised maximum likelihood classification. Supervised maximum likelihood classifier used the Gaussian threshold stored in each class signature to determine if a given pixel fell within class or not. The study with the help of remote sensing facilities has succeeded to highlight the condition and development of the study area during the period 1990 – 2018. The study concluded that although there were some fluctuations in the amount of annual rainfall in the area, there are no enough evidences to support their direct effect on the growth of vegetation cover. The study also indicated that the availability of other vegetation cover, such as grasses, in the forest can reduce the pressure on mature forest tress and seedlings caused by domestic animal herders. In the last decade of the study period, the decrease of forest cover is mostly associated with decrease or absence of vegetation cover as in that case forest trees and young seedlings become the main source of animal feeding. If other forest destruction agents are added due to the absence of management control, the present forest will disappear within the coming five years.
Theoretical approaches to the definition of the sociocultural communication space in the paradigm of linguistic personality formation
Authors: MAKHINOV V. 
Published: January 2023

On the theoretical ground of sociocultural communication space in the paradigm of education, in the context of which the problem of training of future teacher as language personality is presented. The description of sociocultural communication space is presented. The analysis of problem of sociocultural researches and its connection with sociocultural communication is carried out.
Hukuman KoruptorMakin Enteng, Korupsi Makin Marak
Authors: Fitri Aini AfraAzhari  , Mita Fitriani  , Yoseph Hasudungan Siburian  
Published: January 2023

Hukuman yang Masih Rendah Bagi Para Koruptor di Indonesia dinilai tidak sebanding dengan uang yang dikorupsi. Perlu ada inovasi jenis hukuman sebagai efek jera terhadap perampok uang rakyat. Tujuannya satu yaitu agar keuangan negara bisa dipulihkan.
Menariknya justru intensitas hukuman yang diberikan kepada para koruptor kelas kakap lebih rendah dari pada kelas gurem. Koruptor yang mengorupsi negara bermilyar-milyar bahkan triliun hanya mendapat hukuman di bawah 10 tahun. Bahkan ada koruptor yang mendapat fasilitas kamar hotel dalam penjaranya. Mirisnya lagi ada yang bisa bepergian ke luar negeri saat masa tahanan. Ini menunjukkan bahwa hukum kita masih lemah. Rendahnya hukuman yang dijatuhkan kepada para koruptor belum dapat memberikan efek jera, sehingga mereka bisa saja masih terjangkit korupsi pada kasus yang lain.
DETERMINASI STRES KERJA DOKTER GIGI: BEBAN KERJA, LINGKUNGAN KERJA, DUKUNGAN SOSIAL
Authors: Meliawati Meliawati 
Published: January 2023

Riset terdahulu atau riset yang relevan sangat penting dalam suatu riset atau artikel ilmiah. Riset terdahulu atau riset yang relevan berfungsi untuk memperkuat teori dan penomena hubungan atau pengaruh antar variable. Artikel ini mereview Faktor-faktor yang mempengaruhi stress kerja dokter gigi, yaitu beban kerja, lingkungan kerja dan dukungan sosial, suatu studi literatur Manajemen Sumberdaya Manusia. Hasil artikel literature review ini adalah: 1) Beban kerja berpengaruh terhadap stress kerja dokter gigi; 2) Lingkungan kerja berpengaruh terhadap stress kerja dokter gigi; dan 3) Dukungan sosial berpengaruh terhadap stress kerja dokter gigi.
PENGARUH KEPEMIMPINAN TRANSFORMASIONAL DAN TRANSAKSIONAL TERHADAP MOTIVASI KERJA DAN PRESTASI KERJA PEJABAT STRUKTURAL DINAS PENDIDIKAN KABUPATEN MAPPI
Authors: Wen Geradus 
Published: January 2023

Tujuan penelitian ini adalah untuk menguji pengaruh kepemimpinan transformasional dan transaksional terhadap motivasi kerja,dan prestasi kerja pejabat struktural di dinas pendidikan Kabupaten Mappi. Tempat penelitian dilaksanakan di Kantor dinas pendidikan Kabupaten Mappi dengan jumlah pejabat sebanyak 20 orang. Hipotesis dalam penelitian ini sebagai berikut (1) Terdapat pengaruh signifikan dari variabel kepemimpinan transformasional terhadap motivasi kerja, (2) Terdapat pengaruh signifikan dari variabel kepemimpinan transaksional terhadap motivasi kerja, (3) Terdapat pengaruh signifikan dari variabel kepemimpinan transformasional terhadap prestasi kerja, (4) Terdapat pengaruh signifikan dari variabel kepemimpinan transaksional terhadap prestasi kerja, (5) Terdapat pengaruh signifikan dari variabel motivasi kerja terhadap prestasi kerja, (6) Kepemimpinan transformasional dan kepemimpinan transaksional secara bersama-sama mempunyai pengaruh signifikan terhadap motivasi kerja, (7) Kepemimpinan transformasional dan kepemimpinan transaksional secara bersama-sama mempunyai pengaruh signifikan terhadap prestasi kerja.