bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bahan Ajar Digital Berbasis Multiaplikasi Mata Pelajaran IPAS SD
Authors: Fanani Achmad , Rosidah Cholifah Tur , Juniarso Triman , Roys Gresya Ailina , Putri Eldine Salsabila , Vannilia Vannilia 
Published: January 2023

Abstract: IPAS is a new subject in the Merdeka curriculum, a combination of Natural and Social Sciences. It takes the availability of teaching materials as an alternative choice, so that it is possible to support the science learning process to be more fun, practical, and interesting. The problem in this research is how the product form of Digital Teaching Materials Based on Multi-Application Science Materials for Elementary School. This type of research includes development research using a 4-D model design. Development of digital teaching materials using several applications including Google site, Flipbook, Canva, Mentimeter, PowerPoint, Google Form, Life Work Sheet, and X-Mind. The results of this study are expected to be used as examples and descriptions of teaching materials for teachers and prospective teacher students in planning and developing learning, especially related to the integrated blending of content (learning materials and setting experiences, assignments and steps for more effective learning activities according to learning objectives).
Abstrak: IPAS merupakan mata pelajaran baru dalam kurikulum Merdeka gabungan Ilmu Pengetahuan Alam dan Sosial. Dibutuhkan ketersediaan bahan ajar sebagai alternatif pilihan, sehingga memungkinkan dapat mendukung proses pembelajaran IPAS lebih menyenangkan, praktis, dan menarik. Masalah dalam penelitian ini yaitu Bagaimana wujud produk Bahan Ajar Digital Berbasis Multi Aplikasi Mata Pelajaran IPAS SD. Jenis penelitian ini termasuk penelitian pengembangan dengan menggunakan rancangan model 4-D. Pengembangan bahan ajar digital menggunakan beberapa aplikasi diantaranya Google site, Flipbook, Canva, Mentimeter, Power Point, Google Form, Life Work Sheet, dan X-Mind. Hasil penelitian ini diharapkan dapat dijadikan contoh dan gambaran bahan ajar guru dan mahasiswa calon guru dalam merencanakan dan mengembangkan pembelajaran terutama terkait dengan meramu secara terintegeratif antara isi (materi pembelajaran dan penetapan pengalamann, tugas dan Langkah-langkah aktivitas pembelajaran lebih efektif sesuai tujuan pembelajaran).
PENGARUH ENVIROMENTAL MANAGEMENT TERHADAP KINERJA KEUANGAN DENGAN GREEN INNOVATION SEBAGAI VARIABEL MEDIASI
Authors: Bibi Yumna Salvatira , Narsa Niluh Putu Dian Rosalina Handayani 
Published: January 2023

The purpose of this study was to obtain empirical evidence about the mediating role of green innovation (GI) in the relationship between environmental management accounting (EMA) and financial performance (FP). This research is quantitative using path analysis and processed through SPSS. Empirically, through a sample of 144 data on manufacturing companies in the industrial and basic chemical sub-sectors listed on the Indonesia Stock Exchange for the period 2018-2020, it was found that GI is able to mediate EMA against FP. Through GI which results in process and product changes, GI can also increase the efficiency of the use of raw materials, increase product differentiation and reduce the risk of pollution for the company. This research provides knowledge about companies in the basic chemical industry and motivates them in environmental management, especially investment and exploitation of GI.Keywords: environmental management accounting, financial performance, green innovation
ABSTRAKTujuan penelitian ini adalah untuk mendapatkan bukti empiris tentang peran mediasi green innovation (GI) pada hubungan environmental management accounting (EMA) dan financial performance (FP). Penelitian ini bersifat kuantitatif dengan menggunakan path analysis dan diolah melalui software SPSS versi 25. Secara empiris, melalui sampel 144 data perusahaan manufaktur subsektor industri dan kimia dasar yang terdaftar di Bursa Efek Indonesia periode tahun 2018-2020 dan telah memenuhi kriteria yang telah ditentukan, ditemukan bahwa GI mampu memediasi EMA terhadap FP. Melalui GI yang mengakibatkan perubahan proses dan produk, GI juga dapat meningkatkan efisiensi penggunaan bahan baku, meningkatkan diferensiasi produk dan mengurangi risiko polusi bagi perusahaan. penelitian ini memberikan pengetahuan tentang perusahaan dalam industri kimia dasar dan memotivasi mereka dalam pengelolaan lingkungan khususnya investasi dan eksploitasi terhadap GI.Kata Kunci: environmental management accounting, financial performance, green innovation
Effect of ABCB1 Gene Carriage and Drug-Drug Interactions on Apixaban and Rivaroxaban Pharmacokinetics and Clinical Outcomes in Patients with Atrial Fibrillation and Deep Vein Thrombosis
Authors: Fedina L. V. , Sychev I. N. , Rastvorova T. D. , Strigunkova E. V. , Kachanova A. A. , Sozaeva Z. A. , Bochkov P. O. , Vardanyan A. V. , Mirzayev K. B. , Sychev D. A. 
Published: January 2023

Aim. To investigate the effect of ABCB1 gene carriage and interdrug interactions on apixaban pharmacokinetics and clinical outcomes in patients with atrial fibrillation and deep vein thrombosis.Material and methods. Patients hospitalized at Yudin State Clinical Hospital participated in the study. A total of 92 patients (50 patients received apixaban and 42 – rivaroxaban) with non-valvular atrial fibrillation and deep vein thrombosis were included. Genotyping was performed by real-time polymerase chain reaction. Direct oral anticoagulants concentrations were measured using an electrospray ionization mass spectrometer in positive ionization mode.Results. In our study we found that in patients carrying the CT+TT ABCB1 (rs4148738) C>T genotype encoding the carrier protein (P-gp), the plasma concentration of rivaroxaban was statistically significantly higher p= 0.026. In addition, we found that patients taking apixaban together with a CYP3A4/P-gp inhibitor were 3.5 times more likely to have hemorrhagic complications than those without inhibitors p = 0.004.Conclusion. Our study revealed that the plasma concentration of rivaroxaban was higher in patients carrying the ABCB1 (rs4148738) C>T polymorphism T allele. And patients taking apixaban together with CYP3A4/P-gp inhibitor had higher risk of hemorrhagic complications in comparison with patients not taking such drugs. Further studies are needed on the influence of pharmacogenetics and pharmacokinetics on the safety and efficacy profile of apixaban and rivaroxaban, taking into account the trend of systemic approach to optimization of anticoagulant therapy of direct oral anticoagulants based on pharmacokinetic, pharmacogenetic biomarkers.
Regulatory Compliance for Protecting Land Plot Buyers in Sidoarjo: Implications for Legal Action and Buyer Protection
Authors: Condro Rudy , Multazam M Tanzil 
Published: January 2023

This study employs a normative approach to investigate the legal protection for buyers of land plots located in Sidoarjo under Regulation number 59 of 2018. The deductive approach is utilized to prove the truth of the statement that protection for the sale and purchase of land plots can be canceled if not in compliance with the Sidoarjo regulation. The findings reveal that buyers of the land plot can seek legal protection if there are any discrepancies with the regulation. The study concludes that buyers of land plots in Sidoarjo can claim their rights and protection under the Regent's Regulation if there are any issues during the buying and selling process. The study also emphasizes the need to adhere to the regulations to ensure the protection of buyers of land plots.
Highlights:

The study employs a normative approach to investigate legal protection for buyers of land plots in Sidoarjo under Regulation number 59 of 2018.
Buyers can seek legal protection if there are any discrepancies with the regulation during the buying and selling process.
Adhering to the regulations is crucial to ensure the protection of buyers of land plots in Sidoarjo.
The Effect of Workload Rewards and Organizational Commitment on Employee Performance Through Job Satisfaction as an Intervening Variable
Authors: Cahyati Inneke , Sumartik  
Published: January 2023

This study aims to determine the effect of reward (X1), workload (X2), and organizational commitment (X3) on employee performance (Y) through job satisfaction as an intervening variable (Z). This research has a causal concept with the aim of obtaining truth results whether proven or not through the formulated hypothesis and using data analysis. The analytical tool used in this research is path analysis technique with the help of SPSS (Statistical Package for the social science) version 25 for windows. The primary data in this study were obtained from a questionnaire whose measurement was using a Likert scale which was tested using validity and reliability tests. The results of this study show that (1) reward has a positive and significant effect on job satisfaction, (2) workload has a positive and significant effect on job satisfaction, (3) organizational commitment has a positive and significant effect on job satisfaction, (4) rewards have a positive effect and significant to employee performance, (5) workload has a positive and significant effect on employee performance, (6) organizational commitment has a positive and significant effect on employee performance, (7) job satisfaction has a positive and significant effect on employee performance, (8) reward has an effect positive and significant impact on employee performance through job satisfaction as an intervening variable, (9) workload has a positive and significant effect on employee performance through job satisfaction as an intervening variable, (10) organizational commitment has a positive and significant effect on employee performance through job satisfaction as an intervening variable.
A novel controller algorithm to improve stability of power system based on hybrid of Fuzzy controller and Gray wolf optimization by coordinating PSS and TCSC with considering uncertainty
Authors: Abedini Mohamad 
Published: January 2023

Abstract

In this paper, a control scheme which combined the fuzzy controller and the optimal linear-quadratic regulator (LQR) controller is presented to increase the stability of the power system under different disturbance conditions. In addition, an optimization algorithm called Gray Wolf Optimizer (GWO) was also used to adjust the limits of fuzzy functions in order to response to possible variations applied on the system. Power system controllers including power system stabilizer (PSS) and thyristor controlled series capacitor (TCSC) were used simultaneously, and the controller coefficients as well as weighting matrices were also designed, optimally. Seven different scenarios related to the system under study were considered to show the controller's performance. The simulation results show that proposed Fuzzy-GWO controller having a proper operation and also having lower values of settling time and overshoot in comprising with other tradition controller methods.
A shuffled frog leaping-based hyper heuristic algorithm for material feeding scheduling optimization in an automatic monorail shuttle system
Authors: Zhou Binghai , Zhao Lingwei 
Published: January 2023

Abstract
In recent years, mixed-model assembly lines (MMALs) have been widely adopted by the automotive enterprises to face the requirements of mass customization. Meanwhile, the diversified components of various end products are placing the material feeding processes at great challenges. Under this circumstance, to raise the material feeding efficiency, this paper proposes an automatic monorail shuttle system (AMSS) based on line-integrated supermarkets applied to the MMALs by introducing the load-exchangeable shuttles and crossovers. Considering the importance of cost-control in manufacturing enterprises, we establish a mathematical model with the objective to minimize the total costs of the material feeding system, which includes the installation costs of crossovers and the input and operation costs of load-exchangeable shuttles. Then, due to the NP-hard nature of the proposed problem, a shuffled frog leaping-based hyper heuristic (SBHH) algorithm is developed to determine the allocation and scheduling of the shuttles and crossovers, which adopts the shuffled frog leaping algorithm (SFLA) as the high-level heuristic to select the low-level heuristics. To improve the performance of the algorithm, the concept of ‘dynamic decision unit’ is presented to raise the solution accuracy and the convergence speed. Finally, the simulation results verified the superiority of the proposed SBHH algorithm both in solution quality and convergence speed by comparing with other optimization algorithm in the existing literature.
An adaptive approach for preserving privacy in context aware applications for smartphones in cloud computing platform
Authors: Gadiyar H. Manoj T. , G.S Thyagaraju , Goudar R H 
Published: January 2023

Abstract
With the widespread use of mobile phones and smartphone applications, protecting one’s privacy has become a major concern. Because active defensive strategies and temporal connections between situations relevant to users are not taken into account, present privacy preservation systems for cell phones are often ineffective. This work defines secrecy maintenance issues similar to optimizing tasks, thereby verifying their accuracy and optimization capabilities through a hypothetical study. Many optimal issues arise while preserving one’s privacy and these optimal issues are to be addressed as linear programming issues. By addressing linear programming issues, an effective context-aware privacy-preserving algorithm (CAPP) was created that uses an active defence strategy to determine how to release a user’s current context to enhance the quality of service (QoS) regarding context-aware applications while maintaining secrecy. CAPP outperforms other standard methodologies in lengthy simulations of actual data. Additionally, the minimax learning algorithm (MLA) optimizes the policy users and improves the satisfaction threshold of the context-aware applications. Moreover, a cloud-based approach is introduced in our work to protect the user’s privacy from third parties. The obtained performance measures are compared with existing approaches in terms of privacy policy breaches, context sensitivity, satisfaction threshold, adversary power, and convergence speed for online and offline attacks.
Enhanced recovery after laparoscopic cholecystectomy: A single-center experience
Authors: Li Ming-zhe , Xin Chen , Wang Chen , Shi-zeng Li , Xia Bin , Wu Wen-hui , Zhang Chang-hua , He Yu-long 
Published: January 2023

Abstract
Background: The role of Eintraoperative joint organ removal or transit abdominal surgery recovery after surgery (ERAS) in reducing hospital stay time and perioperative hospitalization costs have been proven. However, most studies have been carried out in areas rich in medical resources. In this study, we evaluated the safety and efficacy of ERAS compared with traditional perioperative period care for laparoscopic cholecystectomy (LC) in areas poor in medical resources in China.
Methods: A randomized controlled trial on laparoscopic cholecystectomy was conducted at The People's Hospital of Fengqing from July 2020 to March 2021. Patients were randomly divided into an ERAS group and a traditional care group. The main outcome was the length of hospital stay after surgery. The secondary outcomes included hospitalization costs and visual analogue scale (VAS) scores for postoperative pain, first exhaust time, and first semi-liquid diet time after surgery. The ERAS group was provided with perioperative education, nutritional support, preoperative 2 h oral carbohydrates, restricted rehydration, intraoperative insulation, no drainage tubes, wound hemp, early mobilization postoperative nausea and vomiting (PONV) prevention and multi-modal analgesia, early activity.
Results: The study was conducted on a total of 140 patients with 70 patients each in the ERAS group and traditional care groups. In the ERAS group, The length of hospital stay after surgery was shorter (4.06 vs.4.61 days, P<0.05), the average hospitalization cost (CNY 7900 vs. 8470, P<0.05),and VAS score (3.10 vs. 3.57 points, compared to the eraser group P<0.001) was lower, the first exhaust time was shorter (12.2 vs. 14.2 hours, P<0.001), the first semi-liquid diet time after surgery was shorter(14.5 vs. 16.8 hours, P<0.001), and the incidence of major postoperative complications was lower (bile leakage, postoperative bleeding, bile duct damage) (0% vs. 12.9%, P<0.05). No significant difference in surgery time (57.8 vs. 54.6 min, P>0.05) was observed between the two groups.
Conclusion:Even in areas poor in medical resources in China, the use of the ERAS concept for LC surgery can reduce the length of hospital stay, cut down the cost of hospitalization, and lessen the pain of patients after surgery and accelerate postoperative recovery.
The Relationship between Long-term use of Nonsteroidal Anti-inflammatory Drugs and Kidney Function in Patients with Ankylosing Spondylitis
Authors: Koo Bon San , Hwang Subin , Park Seo Young , Shin Ji Hui , Kim Tae-Hwan 
Published: January 2023

Abstract
Background
Although nonsteroidal anti-inflammatory drugs (NSAIDs) are the first-line treatment for ankylosing spondylitis (AS), their effect on kidney function remains unclear. This longitudinal study investigated the correlation between long-term NSAID use and kidney function in patients with AS using electronic medical records.
Methods
The electronic medical records of 1,280 patients with AS collected from a single center between January 2001 and December 2018 were reviewed. The Assessment of Spondyloarthritis International Society (ASAS) NSAID Intake Score was used to determine the cumulative dose of all NSAIDs prescribed for a different time intervals. Each ASAS NSAID Intake Score was obtained for intervals of 6 months, 1 year, 2 years, 3 years, 5 years, and 10 years. The correlation between the ASAS NSAID Intake Score and final estimated glomerular filtration rate (eGFR) for each interval was investigated.
Results
The mean ASAS Intake Scores for 6-month, 1-year, 2-year, 3-year, 5-year, and 10-year intervals were 55.30, 49.28, 44.84, 44.14, 44.61, and 41.17, respectively. At each interval, the pearson correlation coefficients were − 0.018 (95% CI: -0.031 ‒ -0.006, p = 0.004), -0.021 (95% CI: -0.039 ‒ -0.004, p = 0.018), -0.045 (95% CI: -0.071 ‒ -0.019, p = 0.001), -0.069 (95% CI: -0.102 ‒ -0.037, p < 0.001), -0.070 (95% CI: -0.114 ‒ -0.026, p = 0.002), -0.019 (95% CI: -0.099 ‒ 0.062, p = 0.645), respectively. There was a very weak negative relationship between ASAS Intake Score and eGFR at each interval.
Conclusion
Long-term NSAID use did not correlate with kidney function based on real-world data in patients with AS.
Post-fast refeeding enhances intestinal stem cell-mediated regeneration and tumourigenesis through mTORC1-dependent polyamine synthesis
Authors: Imada Shinya , Shin Heaji , Khawaled Saleh , Meckelmann Sven , Whittaker Charles , Correa Renan , Pradhan Dikshant , Calibasi Gizem , Nascentes Luiza Nascentes , Allies Gabriele , Wittenhofer Pia , Schmitz Oliver , Roper Jatin , Vinolo Marco , Cheng Chia-Wei , Tasdogan Alpaslan , Yilmaz Ömer 
Published: January 2023

Abstract

For more than a century, fasting regimens have improved health, lifespan, and tissue regeneration in diverse organisms, including humans. However, how fasting and post-fast refeeding impact adult stem cells and tumour formation has yet to be explored in depth. Here, we demonstrate that post-fast refeeding increases intestinal stem cell (ISC) proliferation and tumour formation: Post-fast refeeding augments the regenerative capacity of Lgr5+ intestinal stem cells (ISCs), and loss of the tumour suppressor Apc in ISCs under post-fast refeeding leads to a higher tumour incidence in the small intestine and colon than in the fasted or ad libitum (AL) fed states. This demonstrates that post-fast refeeding is a distinct state. Mechanistically, we discovered that robust induction of mTORC1 in post-fast-refed ISCs increases protein synthesis via polyamine metabolism to drive these changes, as inhibition of mTORC1, polyamine metabolite production, or protein synthesis abrogates the regenerative or tumourigenic effects of post-fast refeeding. Thus, fast-refeeding cycles must be carefully considered when planning diet-based strategies for regeneration without increasing cancer risk, as post-fast refeeding leads to a burst not only in stem cell-driven regeneration but also in tumourigenicity.
Characterization of murine isogenic normal and NRF2-KO colon epithelial cells to explore the food contaminants toxicity and oxidative stress involvement.
Authors: Dupuy Jacques , Fouché Edwin , Noirot Céline , Martin Pierre , Buisson Charline , Guéraud Françoise , Pierre Fabrice , Héliès-Toussaint Cécile 
Published: January 2023

Abstract
Cell lines are a useful tool for cellular metabolism and xenobiotic toxicity studies, but for modeling biological effects of molecules on healthy cells or cancer promotion it appeared necessary to develop a cellular model in a normal genetic context without mutations inherent to carcinogenic transformations. Colon mucosa is currently the target of xenobiotics such as food contaminants or naturally produced biomolecules from digestion, compelling normal cells to deal with toxic effects that can lead to genotoxicity and carcinogenic transformations. The toxicological properties of such compounds may rely on reactive oxygen species generation (ROS) which causes oxidative stress. One of the major regulators of ROS metabolism and antioxidant cellular defense is the transcription factor Nrf2. We developed a dual-cell model comparing normal murine epithelial cells with their Nrf2-KO isogenic cells generated through the CRISPR /Cas9 technique. HNE (4-hydroxy-2-nonenal), a lipid peroxidation product resulting from red meat digestion, inducing oxidative stress was used as a model molecule to evaluate normal epithelial cell response to food contaminant toxicity, and the importance of Nrf2 in the cellular protection against ROS injury. Implications of glutathione levels, gene regulation, viability, cell proliferation, and genotoxicity are discussed.
A spatial map of human macrophage niches reveals context-dependent macrophage functions in colon and breast cancer.
Authors: Matusiak Magdalena , Hickey John , Luca Bogdan , Lu Guolan , Kidzinski Lukasz , Zhu Shirley , Colburg Deana , Phillips Darci , Brubaker Sky , Charville Gregory , Shen Jeanne , Nolan Garry , Newman Aaron , West Robert , de Rijn Matt van 
Published: January 2023

Abstract
Tumor-associated macrophages (TAMs) display heterogeneous phenotypes. Yet the exact tissue cues that shape macrophage functional diversity are incompletely understood. Here we discriminate, spatially resolve and reveal the function of five distinct macrophage niches within malignant and benign breast and colon tissue. We found that SPP1 TAMs reside in hypoxic and necrotic tumor regions, and a novel subset of FOLR2 tissue-resident macrophages (TRMs) supports the plasma cell tissue niche. We discover that IL4I1 macrophages populate niches with high cell turnover where they phagocytose dying cells. Significantly, IL4I1 TAMs abundance correlates with anti-PD1 treatment response in breast cancer.
Furthermore, NLRP3 inflammasome activation in NLRP3 TAMs correlates with neutrophil infiltration in the tumors and is associated with poor outcome in breast cancer patients. This suggests the NLRP3 inflammasome as a novel cancer immunotherapy target. Our work uncovers context-dependent roles of macrophage subsets and suggests novel predictive markers and macrophage subset-specific therapy targets.