bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modeling and analysis of axial thermal error in machining space of double-swing five-axis machine tool
Authors: Wang Yupeng , Wu Shi , Liu Xianli , Zhang Yong , Wang Chunfeng 
Published: June 2023

Abstract
The axial thermal error of five-axis CNC machine tools is a significant factor affecting the machining accuracy. To predict the axial thermal error during the machining process, a method is proposed to model axial thermal error in the machining space of five-axis machine tools with a double swing table. The comprehensive thermal error model of the machining space is first established, which includes the axial thermal error of the spindle, worktable, and other components. The spindle is then simplified as a rod, and an analytical model for the axial thermal error of the spindle is developed based on the heat transfer governing equations. This model enables the determination of the time-varying behavior of the axial thermal error at different speeds. Furthermore, the worktable is simplified as a circular plate and the analytical model for the axial thermal error of the worktable is established based on the thermal bending differential equation of the small deflection circular plate. This model allows for the determination of the time-space variation of the axial thermal error at different radii of the worktable. Finally, based on the axial comprehensive thermal error field of the five-axis CNC machine tool processing space, the distribution of the axial thermal error in the machine tool processing space under thermal equilibrium conditions is revealed. Experimental verification of the proposed model is conducted on the VMC-C50 double swing five-axis CNC machine tool. The experimental results show that the error between the measured axial thermal error value and the axial comprehensive thermal error model value is within 26.6%, thus confirming the accuracy of the proposed model.
Evaluation of safety state for dump slope in-service under severe drying-wetting cycles at high altitude
Authors: Dong Jianjun , Jiang Hao , Yang Di , Gao Ke 
Published: June 2023

Abstract
This study aimed to evaluate the safety of dump slopes in high-altitude areas subjected to severe dry-wet cycles. The in-service dump slopes No.1 and No.2 of the cement-used limestone mine in a high-altitude mining area were investigated. Based on the unsaturated-saturated seepage theory, incorporating the unsaturated soil shear strength equation and the matrix suction distribution equation, numerical calculations have been conducted to assess the evolution characteristics of the unsaturated-saturated seepage field and to evaluate the safety status of the dump slopes. The results indicate that the surface soil of the dump slopes shifted from an unsaturated state to a saturated state under dry-wet cycle conditions. Furthermore, as the dry-wet cycle times increased, the maximum vertical displacement of the No.1 and No.2 dump slopes increased. The numerical calculations of the maximum cumulative vertical displacement of the slope were consistent with the actual monitoring data. Although the factor of safety(FOS) of the slope decreased, it still met the safety and stability standards. Therefore, it concluded that the No.1 and No.2 in-service dump slopes were in a stable state under severe dry-wet cycle conditions.
Soil sulfide accumulation and stress mitigation of S. alterniflora by radial oxygen loss and iron enrichment in rhizosphere
Authors: Zhao Zhenzhen , Hua Jing , Cheng Liyu , Li Yuanhang , Chen Xueping , Liu Xiaoyan , HE Chiquan , Wang Daoyuan 
Published: June 2023

Abstract
Background and Aims Spartina alterniflora (S. alterniflora) is an invasive plant widely distributed in coastal areas of China, and the invasion has caused the accumulation of soil sulfur contents, while sulfide can accumulate to phytotoxic levels. It has been verified that S. alterniflora is more tolerant to sulfide than Scirpus mariqueter (S. mariqueter). Therefore, sulfide may play an important role in invading S. alterniflora, but the specific mechanism awaits further investigation. Methods Through experiments with situ rhizoboxes in the Jiuduansha Wetland, we conducted field investigations to analyze soil sulfur (sulfate and sulfide) contents, iron (Fe(II) and Fe(III)) contents, and physicochemical properties. Lab-scale experiment with high-resolution (HR) diffusive gradients in thin films (DGT) was conducted to investigate the distribution of oxygen, sulfide, and iron concentrations in the microenvironment of two species. Meanwhile, the effect of roots on soil bacterial communities and sulfur cycle-related microorganisms was investigated. Results The soil sulfur (sulfide and sulfate) contents in S. alterniflora were higher than in S. mariqueter. In the rhizoboxes of S. alterniflora, the contents of soil sulfide were significantly lower in the rhizosphere, while oxygen contents in the rhizosphere were higher than in bulk soil. The iron contents in S. alterniflora were significantly higher than in S. mariqueter, especially the Fe(III) contents were higher in the rhizosphere. Conclusion The S. alterniflora may gain an advantage in the invasion process by oxidizing the sulfide through radial oxygen loss and by enriching iron to mitigate high concentrations of sulfide in the rhizosphere.
Conceptual framework for Tinnitus: A cognitive model in practice
Authors: Ghodratitoostani Iman , Vaziri Zahra , Neto Milton Miranda , Carneiro Camila de Giacomo , Delbem Alexandre , Hyppolito Miguel , Jalilvand Hamid , Louzada Francisco , Leite Joao 
Published: June 2023

Abstract
Tinnitus is a conscious attended awareness perception of sourceless sound. Widespread theoretical and evidence-based neurofunctional and psychological models have tried to explain tinnitus-related distress considering the influence of psychological and cognitive factors. However, tinnitus models seem to be less focused on causality, thereby easily misleading interpretations. Also, they may be incapable of individualization. This study proposes a Conceptual Cognitive Framework (CCF) providing insight into cognitive mechanisms involved in the predisposition, precipitation, and perpetuation of tinnitus and consequent cognitive-emotional disturbances. The current CCF for tinnitus relies on evaluative conditional learning and appraisal, generating negative valence (emotional value) and arousal (cognitive value) to annoyance, distress, and distorted perception. The suggested methodology is well-defined, reproducible, and accessible, which can help foster future high-quality clinical databases. Perceived tinnitus through the perpetual-learning process can always lead to annoyance, but only in the clinical stage directly cause annoyance. In the clinical stage, tinnitus perception can lead to distress only with experiencing annoyance either with (“Ind-1C ” = 1.87; 1695% CI 1.18-2.72)or without (“Ind-2C” = 2.03; 95% CI 1.02-3.32) the perpetual-learning process. Further real-life testing of the CCF is expected to express a meticulous, decision-supporting platform for cognitive rehabilitation and clinical interventions. Furthermore, the suggested methodology offers a reliable platform for CCF development in other cognitive impairments and supports the causal clinical data models. It may also enhance our knowledge of psychological disorders and complicated comorbidities by supporting the design of different rehabilitation interventions and comprehensive frameworks in line with the ``preventive medicine'' policy.
Hepatic Papillomatosis in a middle-aged cat
Authors: Mponda Phanuel , Olive Melanie 
Published: June 2023

Abstract

Background
According to the authors’ knowledge biliary papillomatosis is a rare disease and has not yet been described in animals. Episodes of recurrent cholangitis and associated icterus have been associated with biliary papillomatosis and confirmation of diagnosis is via histopathology, where it is characterized by the proliferation of the columnar papillary epithelium of the bile ducts. This epithelium extends into the lumen, partially or completing obstructing it.
Case presentation
A 8-year-old neutered domestic short-hair cat was presented for evaluation of recurrent generalized muscle atrophy, abdominal distension and marked icterus. One year before presentation, the cat was diagnosed with chronic lymphocytic cholangitis associated with intrahepatic cholestasis. Treatment was initiated with prednisolone (Dermipred; Ceva) at 2mg/kg Per Os (PO) q24 for 2 weeks then reduced to 1mg/kg PO q24h and S-adenosylmethionine 20 mg/kg (Zentonil;Vetoquinol). On presentation, the cat had marked icterus and abdominal distension. Results of abdominal ultrasound revealed large fluid lesions on hepatic parenchyma with marked dilated bile ducts. An exploratory laparotomy was performed and cystic structures were identified on the right lateral and on central division of the liver. Cholecystectomy and hepatic lobectomies with omentalization at the base of the cystic structures were performed. Histopathological analysis revealed the presence of benign papillomatosis. The cat was re-examined 2 weeks after surgery at which point clinical examination was normal. Four months after surgical intervention, the cat had recurrent clinical signs, and abdominal ultrasound revealed the presence of a large volume abdominal effusion and diffuse cystic changes within the rest of the liver. At this stage the owners elected for euthanasia.
Conclusion
To our knowledge, this is the first description of papillomatosis in animals.
The final diagnosis was biliary papillomatosis which has never been reported in cats. The diagnosis can be difficult and it’s also a rare condition in human medicine. Biliary papillomatosis should be included in the differential diagnosis of hepatic cystic-like lesions in cats.
Novel insights into the pathogenesis of follicular lymphoma by molecular profiling of localized and systemic disease forms
Authors: Ott German , Kalmbach Sabrina , Grau Michael , Zapukhlyak Myroslav , Leich Ellen , Jurinovic Vindi , Hoster Eva , Staiger Annette , Kurz Katrin , Weigert Oliver , Gaitzsch Erik , Passerini Verena , Engelhard Marianne , Herfarth Klaus , Beiske Klaus , Micci Francesca , Möller Peter , Bernd Heinz-Wolfram , Feller Alfred , Klapper Wolfram , Stein Harald , Hansmann Martin-Leo , Hartmann Sylvia , Dreyling Martin , Holte Harald , Lenz Georg , Rosenwald Andreas , Ott German , Horn Heike 
Published: June 2023

Abstract
Knowledge on the pathogenesis of FL is mainly based on data derived from advanced/systemic stages of FL (sFL) and only small cohorts of localized FL (lFL) have been characterized intensively so far.
Comprehensive analysis with profiling of somatic copy number alterations (SCNA) and whole exome sequencing (WES) was performed in 147 lFL and 122 sFL. Putative targets were analyzed for gene and protein expression.
Overall, lFL and sFL, as well as BCL2translocation-positive (BCL2+) and –negative (BCL2-) FL showed overlapping features in SCNA and mutational profiles. Significant differences between lFL and sFL, however, were detected for SCNA frequencies, e.g. in 18q-gains (14% lFL vs. 36% sFL; p=0.0003). Although rare in lFL, gains in 18q21 were associated with inferior progression-free survival (PFS). The mutational landscape of lFL and sFL included typical genetic lesions. However, ARID1A mutations were significantly more often detected in sFL (29%) compared to lFL (6%, p=0.0001). In BCL2+ FL mutations in KMT2D, BCL2, ABL2, IGLL5 and ARID1A were enriched, while STAT6mutations more frequently occurred in BCL2- FL. Although the landscape of lFL and sFL showed overlapping features, molecular profiling revealed novel insights and identified gains in 18q21 as prognostic marker in lFL.
The impact of phage treatment on bacterial community structure is negligible compared to antibiotics
Authors: Gundersen Madeleine S. , Fiedler Alexander W. , Bakke Ingrid , Vadstein Olav 
Published: June 2023

Abstract
Background
Phage treatment is suggested as an alternative to antibiotics; however, there is limited knowledge of how phage treatment impacts resident bacterial community characteristics. When phages induce bacterial lysis, resources become available to the resident community. Therefore, the density of the target bacteria is essential to consider when investigating the effect of phage treatment but has never been studied. Thus, we invaded microcosms containing a lake-derived community with Flavobacterium columnare strain Fc7 at no, low or high densities and treated them with either the bacteriophage FCL-2, the antibiotic Penicillin or kept them untreated (3x3 factorial design). The communities were sampled over the course of one week, and bacterial community composition and density were examined by 16S rDNA amplicon sequencing and flow cytometry.
Results
We show that phage treatment had negligible impacts on the resident community when the phage host F. columnare Fc7 was present, as it caused insignificant differences in bacterial density, α- and β-diversity, successional patterns, and community assembly. However, a significant change was observed in community composition when the phage host was absent, mainly driven by a substantial increase in Aquirufa. In contrast, antibiotics induced significant changes in all community characteristics investigated. The most crucial finding was a bloom of γ-proteobacteria and a shift from selection to ecological drift dominating community assembly.
Conclusions
This study investigated how phage host density impacts phage treatment effects and provides strong evidence that bacteriophages do not significantly affect the composition of bacterial communities. The findings highlight the importance of considering the density of target bacteria when investigating the effect of phage treatment, as more changes were observed when the phage host was absent. Moreover, higher phage host densities increased the contribution of stochastic community assembly and resulted in a feast-famine like response in bacterial density. This finding emphasises that the invader density used in bacterial invasion studies impacts the experimental reproducibility. Overall, this study supports that phage treatment is substantially less disturbing to bacterial communities than antibiotic treatments.
Exploring the Structural and Electronic Characteristics of Phenethylamine Derivatives: A Density Functional Theory approach
Authors: B Arya , P Sachidanandan , S Jayasudha , M Deepa , M Anandakumar V 
Published: June 2023

Abstract
Accurate structure elucidation of biologically active molecules is crucial for designing and developing new drugs, as well as for analyzing their pharmacological activity. In this study, density functional theory calculations are applied to explore the electronic structure and properties of phenethylamine derivatives, including Amphetamine, Methamphetamine, and Methylene Dioxy Methamphetamine(MDMA). The investigation encompasses various aspects such as geometry optimization, vibrational analysis, electronic properties, Molecular Electrostatic Potential analysis, and local and global descriptor analysis. Additionally, the study utilizes Natural Bond Orbital analysis and Quantum Theory of Atoms in Molecules to investigate the chemical bonding and charge density distributions of these compounds. Experimental techniques such as Fourier transform infrared (FT-IR) and Raman spectroscopic analysis are employed in the range of 4000-400 cm-1 and 4000-50 cm-1, respectively. Theoretical vibrational analysis with Potential Energy Distribution(PED) assignments is conducted, and the resulting frequencies are compared to experimental spectral data, revealing good agreement. By correlating various structural parameters with the pharmacological activity of each derivative, computational structure elucidation aids in understanding the unique actions of phenethylamine derivatives. The obtained results offer a comprehensive understanding of the molecular behavior and properties of these drugs, facilitating the development of new drugs and therapies for addiction and related disorders.
Turning alterations detected by mobile health technology in idiopathic REM sleep behavior disorder
Authors: pilotto Andrea , Zatti Cinzia , Hansen Clint , Rizzardi Andrea , Catania Marcello , Romijnders Robbin , Purin Leandro , Pasolini Maria , schaeffer eva , Galbiati Andrea , Ferini-Strambi Luigi , Berg Daniela , Maetzler Walter , Padovani Alessandro 
Published: June 2023

Abstract
Introduction: Idiopathic REM sleep Behavior Disorder (iRBD) is a condition at high risk of developing Parkinson’s disease (PD) and other alpha-synucleinopathies. Aim of the study was to evaluate subtle turning alterations by using Mobile health technology (MHT) in iRBD individuals without subthreshold parkinsonism.Methods A total of 148 participants (23 persons with polysomnography-confirmed iRBD without subthreshold parkinsonism, 60 drug-naïve PD patients and 65 age-matched controls (HC)) were included in this prospective cross-sectional study. All underwent a multidimensional assessment including cognitive and non-motor symptoms assessment. Then a Timed-Up-and-Go test (TUG) at normal and fast speed was performed using MHT (Rehagait®, Hasomed, Germany). Durations, mean and peak angular velocities of the turns were compared using a multivariate model correcting for age and sex.Results Compared to HC, PD patients showed longer turn durations and lower mean and peak angular velocities of the turns in both TUGs (all p ≤ 0.001). iRBD participants showed also a longer turn duration and lower mean (p = 0.006) and peak angular velocities (p < 0.001) compared to HC, but only in the TUG at normal speed.Conclusion MHT assessment identified subtle alterations of turning at normal speed in iRBD patients. The lack of difference between iRBD patients and HC at fast speed may indicate the presence of (unconscious) compensation mechanisms that are activated during challenging mobility conditions. Longitudinal studies are warranted to evaluate the value of objective turning parameters in defining the risk of conversion to PD in iRBD and in tracking motor progression in prodromal PD.
Evaluating BMWM scenario of Alwar through KAP index of the hospital staff
Authors: Bhambhani Deepa , Sharma Sunder Lal 
Published: June 2023

Abstract
Purpose
Any type of waste that is produced during medical treatments is called biomedical waste. Because BMW is a complex waste with high degree of quantitative and qualitative variations which arise due to the practices followed by the hospital staff in handling of waste, it is very crucial to analyse the knowledge and attitude of the waste handlers. A qualitative study was thus conducted to assess the knowledge, attitude and practices followed for bio medical waste management by the hospital staff of government and private hospitals of Alwar.
Methods
For this a questionnaire was distributed to 335 respondents and based on the scorecard for the Knowledge, Attitude and Practice scores KAP index was evaluated.
Results
The KAP index as per the scorecard came to be satisfactory for both government and private hospitals, though it was on a better side for the govt hospital staff; indicating a slightly better biomedical waste management in government hospitals as compared to private hospitals. When the socio demography of the respondents was associated with the KAP index it was found that age, occupation, experience and training influenced the KAP index as the P value was > 0.05. Correlation analysis results showed a positive and strong correlation between all the three parameters i.e. Knowledge, Attitude and Practice for bio medical waste management.
Conclusions
The KAP scorecard highlighted that the score of the cleaners, who have the prime responsibility of handling biomedical waste, was moderate so biomedical waste management needs improvements in the hospitals of Alwar.
Identification of disulfidptosis-associated IncRNAs signature and immune response of bladder urothelial carcinoma
Authors: Zhu Shusheng , Fan Yanpeng , Tang Chao 
Published: June 2023

Abstract
Bladder urothelial carcinoma (BLCA) is the most common malignancy of the urinary tract, with a wide range of clinical symptoms and prognosis. Disulfidptosis is newly identified cell death method and closely associated with BLCA progression, prognosis, and treatment outcome. Currently, we need to construct a new prognostic model of disulfidptosis-related long noncoding RNAs (drlncRNAs) to improve the treatment strategy of BLCA. Methods The data of BLCA samples were obtained from The Cancer Genome Atlas (TCGA), then 10 unique disulfidptosis-related genes (DRGs) were obtained from the research papers. The differences between the two groups showed in this study were used to create the “disulfidptosis-related long noncoding RNAs score” (disulfidptosis-score) prognostic model. Results We identified two groups of drlncRNAs with high and low disulfidptosis scores in this study. Patients with low disulfidptosis scores had a better overall survival rate compared to those with high scores in bladder cancer, and the high disulfidptosis score subtype exhibited more active malignant pathways related to cancer than the low score subtype. We found that the low disulfidptosis-score subgroup had better prognosis than the high disulfidptosis-score subgroup. The expression of mutation burden (TMB) was much higher in the low disulfidptosis-score group than in the high disulfidptosis-score group. The low disulfidptosis-score subgroup of patients exhibited significantly higher proportions of plasma cells, T cells CD8, and Tregs, while the high-risk subgroup had a greater abundance of Macrophages M0 and Macrophages M2. The disulfidptosis-score showed a strong correlation with the sensitivity of chemotherapeutic drugs, and patients in the low disulfidptosis-score group were more likely to exhibit an immune response and respond positively to immunotherapy. Additionally, we developed a nomogram to enhance the accuracy of the disulfidptosis-clinical score. Conclusion Based on our investigation of disulfidptosis-score in BLCA, disulfidptosis-score may have an important role in TME, prognosis, and drug sensitivity. We also investigated the significance of the disulfidoptosis-score in relation to immunotherapy and immune response, providing a basis for improving prognosis and responding to immunotherapy among patients with BLCA.