bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efek Pemberian Tiamin Oral sebagai Adjuvan Opioid terhadap Kadar Enzim Cathecol-O-Methyltransferase (COMT) pada Penderita Kanker Serviks
Authors: Bastian Sirait Ferdinan , Wirawan Nur Surya , Ahmad Muh. Ramli , Gaus Syafruddin , Ala Husain Alamsyah Ambo , Datu Madonna Damayanthie 
Published: April 2023

Latar Belakang: Jumlah nyeri kanker yang masih tinggi menunjukkan bahwa penanganan nyeri kanker masih belum maksimal. Alternatif tambahan pengobatan yang banyak diteliti pada pasien kanker saat ini adalah vitamin B. Enzim Cathecol-O-Methyltransferase (COMT) merupakan salah satu faktor penting munculnya gejala nyeri yang mungkin dapat dicegah dengan memberikan tiamin.
Tujuan: Mengetahui efek pemberian tiamin oral sebagai adjuvan opioid terhadap kadar COMT pada penderita kanker serviks.
Metode: Penelitian ini merupakan penelitian quasi-experimental dengan desain pretest-posttest control group. Pasien penelitian ini berjumlah 32 pasien kanker serviks yang mengalami nyeri kanker yang dibagi dalam 2 kelompok (kelompok perlakuan dan kontrol). Kelompok perlakuan yang mendapatkan morfin ditambah dengan tiamin 500 mg/8 jam/oral, dan kelompok kontrol yang mendapatkan morfin saja. Pengukuran dan evaluasi skor numeric rating scale (NRS) dilakukan setelah 72 jam pemberian tiamin dan dilakukan pengambilan darah kembali 4 jam setelah pemberian tiamin yang terakhir untuk pemeriksaan kadar COMT, kemudian dilakukan pengumpulan dan analisis data.
Hasil: Dari 32 pasien kanker serviks yang diteliti didapatkan hasil bahwa terdapat perbedaan perubahan tingkat NRS dan kadar COMT pada kelompok perlakuan yang diberikan tiamin.
Simpulan: Pemberian tiamin dapat menurunkan kadar enzim COMT dan secara klinis menurunkan NRS pada pasien dengan kanker serviks.
Efek Tindakan Transcranial Magnetic Stimulation (TMS) terhadap Derajat Nyeri dan Kadar Beta-Endorfin Serum pada Pasien Nyeri Kanker Payudara
Authors: Ramadhaniah Noor , Wirawan Nur Surya , Musba A.M. Takdir , Hamid Firdaus , Ahmad Muh. Ramli , Ala Husain Alamsyah Ambo , Datu Madonna Damayanthie 
Published: April 2023

Latar Belakang: Nyeri adalah keluhan yang sering dirasakan oleh pasien kanker. Benjolan tanpa rasa sakit adalah gejala pertama yang dirasakan pada kanker payudara. Pada stadium lanjut, pasien kanker payudara mengalami rasa sakit yang sangat menyiksa karena keterlibatan struktur didalamnya, selain itu nyeri juga dapat disebabkan oleh pengobatan kanker itu payudara itu sendiri. Stimulasi Magnetik Transkranial (SMT) merupakan metode baru stimulasi otak secara non-invasif untuk manajemen nyeri terkait kanker. Pada nyeri kronik, SMT terbukti menurunkan Visual Analogue Score (VAS) dan meningkatkan serum beta-endorfin.
Tujuan: Mengetahui efek tindakan SMT terhadap intensitas nyeri dan kadar beta-endorfin serum serta korelasinya pada pasien nyeri kanker payudara.
Subjek dan Metode: Penelitian ini merupakan penelitian prospective randomized controlled trial dengan desain pretest-posttest control group. Sampel terdiri dari 2 kelompok, yaitu kelompok P1 (kelompok dengan intervensi SMT) dan P2 (kelompok kontrol) dengan jumlah sampel masing-masing 20 orang yang memenuhi kriteria inklusi. Dilakukan penilaian Numeric Rating Scale (NRS) dan pengambilan darah untuk pemeriksaan kadar beta endorfin serum sebelum dan sesudah intervensi. Data dianalisis menggunakan uji statistik Mann-Whitney dan Wilcoxon, serta uji korelasi dengan uji Spearman.
Hasil: Penurunan NRS lebih besar pada kelompok P1 dibandingkan kelompok P2 dengan nilai p<0.001 dan terjadi peningkatan kadar beta endorfin serum pada kelompok P1 dibandingkan dengan kelompok P2 dengan nilai p<0.001, hal ini memiliki korelasi kuat (r=0.630; p<0.001)
Simpulan: Tindakan SMT menyebabkan penurunan intensitas nyeri dan meningkatkan kadar beta endorfin serum pada pasien nyeri kanker payudara dan ditemukan korelasi antar kedua variabel ini.
Kata kunci: nyeri kanker, SMT, NRS, beta endorfin
Waarom in evaluaties niet altijd de goede vragen worden gesteld: de casus arbeidsmarktbeleid
Authors: Mevissen Jos 
Published: April 2023

Waarom in evaluaties niet altijd de goede vragen worden gesteld: de casus arbeidsmarktbeleid
Beleidsonderzoek vindt plaats binnen een heersend beleidsparadigma. Daardoor is de kans groot dat relevante vragen niet gesteld worden. Vragen die tot inzichten kunnen leiden die niet goed passen binnen het heersende beleid. Waarom is dit zo? Geïnspireerd door een recent boek over arbeidsmarktbeleid geeft de auteur drie mogelijke verklaringen ter overweging.
De ruimschoots toereikend-verklaring, de erfgenamen en de tuchtrechter
Authors: Breemhaar W. 
Published: April 2023

De ruimschoots toereikend-verklaring, de erfgenamen en de tuchtrechter
De bijdrage onderzoekt hoe de notaris dient te handelen, indien de executeur zich in een nalatenschap die aanvaard is onder het voorrecht van boedelbeschrijving tot de notaris wendt voor de afgifte van een verklaring van erfrecht. Daarbij komt de positie van de erfgenamen ten opzichte van de ruimschoots toereikend-verklaring van de executeur aan de orde en het door de tuchtrechter geëiste summiere onderzoek van de ruimschoots toereikend-verklaring van de executeur.
The Impact of Child Life Intervention on a Clinical Vaccine Trial
Authors: Wright Hope E. , Gerson Jennifer S. , Staab Jennifer H. 
Published: April 2023

Objective: Needle-related procedures, such as vaccines, can be especially stressful for children. One children’s hospital secured funding to staff a child life specialist to provide support to patients enrolled in a vaccine trial. Method: Data was collected to explore how participants coped through multiple nasal swabs, blood draws, and injections and the impact of providing child life support during a clinical research trial. Results: Children supported by a child life specialist for their vaccine exhibited low distress and utilized coping strategies frequently. Participant retention was higher than expected during the clinical trial. Conclusion: The study findings suggest including child life specialists as part of clinical trial teams in future studies. Disclosure Statement: No potential conflict of interest was reported by the author(s). Funding Statement: No funding sources were provided by the author(s).
Prediksi Deret Waktu Manajemen Lalu Lintas
Authors: Albab M Ulul , Anjarsari Elly , Febriyanti Rahma , Fatimah Marissa Dewi 
Published: April 2023

Optimizing customer service for the number of drivers in an area through real-time transportation service industry online to scale up. In this paper, the dataset used is traffic management accompanied by attributes such as level 6 geohash, day, timestamp, and demand. The dataset used is a sample from geohash6 coded qp0991, containing online transportation demands from 01/04/2018 until 31/05/2018 (61 days). The training datasets are from the qp0991 code sample, starting from 01/04/2018 until 10/05/2018 and the remaining datasets are used as the testing datasets. The percentages for training and testing are respectively 67% and 33%. The methods applied to construct the objective function are three different forecasting methods, namely the Naïve approach, auto-regressive integrated moving average (ARIMA), and simple exponential smoothing. The results of this study indicate that the simple exponential smoothing method is better than the naïve approach and auto-regressive integrated moving average based on the root mean square error (RMSE), mean absolute error (MAE), and mean absolute percentage error (MAPE). The simple exponential smoothing has an accuracy rate of 98.7% for the RMSE value, 98.9% for the MAE value, and 88.81% for the MAPE value.
Keywords: time series, traffic management
Layanan Bimbingan Karir Dalam Meningkatkan Perencanaan Karir
Authors: Neva Marneva Nailul Amni , Irman Irman 
Published: April 2023

This study aims to improve students' career planning class X at Madrasah Aliyah (MA) Plus An Nahl Kabupaten Lima Puluh Kota through the Career Guidance Service. Based on the results of observations made by researchers before providing services in these classes there are still many students who do not have career plans. Based on the data obtained, the researcher conducted an action research that refers to career guidance service activities. The reason the researcher will provide career guidance service action is because the counseling teacher does not carry out the service and considers this service necessary to be provided to service participants. This activity is monitored using a checklist. From the results of the research carried out, there were several indicators that experienced an increase in the "very good" category, namely the indicator of introduction to the world of work with descriptors seeking information, the total percentage of 100% of 14 students, then Knowing how to choose a study program with a percentage of 93% of 13 students . And the indicator of knowing various types of secondary schools that can support careers has increased with a percentage of 93% of 13 students, and making decisions with a percentage of 93% of 13 students.
Keywords: career guidance;career planning
Analisis Mashlahah pada Tren Pemenuhan Self Esteem dengan Pembelian Buket oleh Mahasiswa UIN Kiai Haji Achmad Siddiq Jember
Authors: Mustafidah Ayyu Ainin , A’yun Qurrota 
Published: April 2023

Penelitian ini bertujuan mendeskripsikan tren pemenuhan self esteem dan analisis mashlahah pada tren pemenuhan self esteem dengan pembelian buket oleh mahasiswa UIN Kiai Haji Achmad Siddiq Jember. penelitian ini merupakan jenis penelitian deskriptif dengan pendekatan penelitian kualitatif. Dalam pemenuhan self esteem mahasiswa UIN Kiai Haji Achmad Siddiq Jember dengan memberikan buket kepada salah satu teman telah melaksanakan sidang proposal maupun sidang skripsi. Tindakan pembelian buket dapat dikatan maslahah karena terdapat manfaat dan tidak mendapatkan kemadharatan. Bentuk kemanfaat yang diperoleh berupa manfaat material, fisik dan psikis, intelektual, lingkungan serta kemanfaatan jangka panjang.
Efecto de Bioestimulantes Orgánicos como Complemento de la Fertilización Edáfica en (Oryza Sativa l.), Variedad SFL-11 Zona Santa Lucía – Guayas.
Authors: Barreto Macías Arnaldo , Jimenez Pluas Roger Steeven , Facuy Delgado Jussen Paúl , Barreto Campoverde Katy Lyz 
Published: April 2023

El presente estudio se realizó en la finca Voluntad de Dios, perteneciente al recinto Cabuyal, cantón Santa Lucía, provincia del Guayas. Los bioestimulantes son utilizados para incrementar el rendimiento de los cultivos, una adecuada aplicación de bioestimulantes, macro y micronutrientes permitirá aumentar el número de macollos y panículas por plantas, alcanzar un mayor diámetro de longitud de la panícula, lo cual mejorará la producción de arroz en el cantón Santa Lucía. En esta investigación se comparó el efecto de bioestimulantes orgánicos como complemento de la fertilización edáfica.
Se utilizó un diseño estadístico de bloques completamente al azar (DBCA) con 7 repeticiones; donde se evaluaron las variables: altura de la planta a los 15, 30, 45 y 60 días, número de macollos, número de panículas, número de granos por panícula, longitud de la panícula, peso de 1000 granos, rendimiento, análisis foliar y análisis económico. En la determinación del mejor tratamiento y dosis de bioestimulante en este estudio, se observó que los tratamientos obtuvieron significancia estadística siendo el tratamiento 1 de extractos de alga marina 100% en dosis de 200 g quien obtuvo el mayor rendimiento con un promedio de 8023.29 kg/ha.En cuanto al análisis económico del estudio de la relación beneficio-costo, se observó que el tratamiento 1 (extracto algas marinas 100% en dosis de 200 g/ha) obtuvo la mayor rentabilidad con un índice de 1.66 seguido del tratamiento 2 (ácido húmico 25% en dosis de 2 L/ha) con 1.50, mientras que el tratamiento 3 (testigo) presentó el menor índice con 1.41.
BULLYING E O CYBERBULLYING NO CONTEXTO ESCOLAR: REFLEXÕES SOBRE ESTE TIPO DE VIOLÊNCIA
Authors: Ramos Élison Davi Crispim , De Carvalho Waldênia Leão , Silva Emilly Daiane Crispim 
Published: April 2023

O presente artigo tem por objetivo fazer uma análise sobre o bullying e o cyberbullyuing no ambiente escolar que pode ser especificado como um agrupamento de ações violentas, realizadas sistematicamente de maneira intencional buscando ridicularizar o outro, sendo sua percepção, no ambiente escolar, um dos objetivos deste estudo, fortalecidos pelas premissas da Lei nº 13.185 de seis de novembro de 2015, que aborda a necessidade das unidades escolares subsidiarem ações de enfrentamento, conscientização, prevenção do bullying e cyberbullying no ambiente escolar. No decorrer do trabalho descreveu-se brevemente sobre bullying e cyberbullying, dando um aprofundamento maior na ocorrência deste tipo de violência no ambiente escolar. Para construção desse estudo foi realizada uma pesquisa bibliográfica através de dados secundários por meio da técnica exploratória descritiva, com a finalidade de conhecer melhor o tema e descrevê-lo, respectivamente. Portanto, conclui-se que o bullying e cyberbullying precisam ser abordados e combatidos em ações pedagógicas de forma estruturada e que sejam potencializadas políticas públicas educacionais que tenham resultados efetivos no enfrentamento dessa violência, uma vez que podem trazer consequências negativas para as vítimas.
Exploring hexacorallian models to aid corals affected by climate change
Authors: Rosental Benyamin 
Published: April 2023

Exploring hexacorallian models to aid corals affected by climate change
In this interview, Benyamin Rosental, PhD, from the Shraga Segal Department of Microbiology, Immunology, and Genetics, looks toward hexacorallian models to transplant stem cells to corals affected by global warming. Why are you researching stem cell transplantation on hexacorallian models? The first step of our research is with our model sea anemones, which are part of the hexacorallia subclass along with stony corals. The purpose of the tool that we are developing is to develop stem cell-based therapies for corals.
Why is engineering design important for all leaners?
Authors: Butler Songer Nancy 
Published: April 2023

Why is engineering design important for all leaners?
Engineering design systematically identifies needs, wants, and problems and then devises solutions to address them. A central component of our work is guiding students in the engineered design of solutions to local environmental problems. Science in society and schools must be for all citizens. Reasons include the desire to prepare citizens with the tools and knowledge to address local and global problems. With funding from the U.S. National Science Foundation, we foster sustained learning of Science, Technology, Engineering, and Mathematics (STEM) for students from primary school through university.
Acute care hospital reform in Japan: Outcomes in quality and market competition
Authors: Konno Hiroki 
Published: April 2023

Acute care hospital reform in Japan: Outcomes in quality and market competition
This paper describes why the fee system for acute care hospital reform in Japan is beginning to show results. It has been 20 years since the Japanese government introduced a comprehensive fee system (the Diagnosis Procedure Combination/Per- Diem Payment System [DPC/PDPS] ) for acute care hospital reform. While the DPC/PDPS was developed to provide visibility into the management and improvement in the management of acute care hospitals, the government's expected policy outcome was a reduction in inpatient care costs. To date, this goal has not been achieved, partly because the design of the DPC/PDPS is imperfect, and the population is aging, and longevity is increasing. However, other outcomes of introducing the DPC/PDPS are beginning to materialize; the first is an improved quality of medical care through an early discharge and segregation of medical functions, and the other is greater competition in the regional healthcare market.
The miniNO project: Helping to minimize risks of premature births
Authors: Chachlaki Konstantina 
Published: April 2023

The miniNO project: Helping to minimize risks of premature births
Associative mechanisms linking a defective minipuberty to the appearance of mental and non-mental disorders: infantile NO replenishment as a new therapeutic possibility. One in ten babies is born too early before 37 weeks of pregnancy have been completed. Sadly, according to the WHO, preterm birth is one of the largest single conditions in the Global Burden of Disease analysis since an estimated 15 million babies are born prematurely every year, facing not only an increased risk of mortality but also a considerable risk of a lifetime of disability, including learning disabilities and visual and hearing problems brought on by altered minipuberty. In 2019, there were 5.30 million deaths among children younger than 5 years with the leading cause of death being preterm birth complications (0.94 million; 17.7%) followed by lower respiratory infections (0.74 million; 13.9%), and intrapartum-related events (0.62 million; 11.6%).
How calorimetry can pave the way for mature and safe sodium-ion batteries
Authors: Ziebert Carlos 
Published: April 2023

How calorimetry can pave the way for mature and safe sodium-ion batteries
Dr Carlos Ziebert, leader of the group Batteries – Calorimetry and Safety, KIT, explains how electrochemical-calorimetric methods help to develop and safely upscale sodium-ion batteries. As part of the German Excellence Initiative, the KIT, the University of Ulm, the Center for Solar Energy and Hydrogen Research Baden-Württemberg, and the University of Giessen jointly launched 2019 the POLiS – Cluster of Excellence for Battery Research Post Lithium Storage, which is funded with 47 million euros over seven years to step away from the usual resources of Lithium, Nickel and Cobalt.
Pay-for-performance schemes: An innovative policy-driven approach for building renovations
Authors: Anagnostopoulos Filippos 
Published: April 2023

Pay-for-performance schemes: An innovative policy-driven approach for building renovations
The SENSEI project is offering 10 recommendations to policymakers that support a performance-based market for energy efficiency in buildings. The European Union (EU) is taking significant steps towards decarbonizing its building sector and EU leaders who agreed to a more ambitious 2030 climate target are working to update key directives and regulations to achieve this goal. Despite these efforts, the EU is facing several long-standing barriers in retrofitting buildings to be more energy efficient. To overcome these barriers, the EU and national public funds need to be more effectively communicated and targeted towards end-users. This can be achieved through blending various sources of financing, proportionate support based on achieved results, strengthened technical assistance, and promoting synergies with market-based mechanisms.
Zero food waste city 2049: Identifying barriers to transition pathways
Authors: Black Daniel , Roderick Ian , Paytan Adina , Charlesworth Sue , Carey Joy 
Published: April 2023

Zero food waste city 2049: Identifying barriers to transition pathways
Daniel Black, Ian Roderick, Adina Paytan, Sue Charlesworth and Joy Carey from an Urban Living Lab in the UK have tested newly integrated systems approaches and valuation methods to understand how to reduce the city's food waste. Food waste costs the UK billions of pounds each year and much of it is avoidable. The challenge for the WASTE FEW ULL research project was to produce and test methods for identifying inefficiencies in the food-energy-water (FEW) nexus in urban settings. Looking in particular at Bristol city, which throws away 48,000 tonnes of food waste each year, the team looked into how they could transform Bristol into a sustainable food city. Stakeholder concerns arose including the nutrient overload problem in water systems and the economic recovery of phosphate; the large amount of food waste from the city linked to food security issues; the energy and carbon footprint of the digestate produced from the anaerobic digestors; the economic challenges of reducing food waste; the plastic contamination of waste streams; sewage system blockages; and the difficulties of recycling sewage and wastewater. This research looks at the challenge of phosphorous recapture from sewage through extensive discussions agreed to shift the project focus to residential food waste reduction and processing (and the associated plastic contamination). The team eventually began looking at the critical concept of resilience and economic efficiency, working to substantially reduce inefficiencies in a city-regions FEW nexuses.
The potential of microparticles for active surveillance of infectious diseases
Authors: Kifaro Emmanuel George 
Published: April 2023

The potential of microparticles for active surveillance of infectious diseases
Emmanuel Kifaro from the SACIDS Foundation for One Health, and College of Veterinary Medicine and Biomedical Sciences, Sokoine University of Agriculture, Tanzania, details the potential application of microparticles for active surveillance of viral infections from non-invasive animal matrices. The tremendous increase in the occurrence of infectious diseases and drug resistance poses higher risks to global health, but microparticles could aid the surveillance of these pathogens before they spread. Infectious diseases of viral origin have emerged as potentially dangerous pathogens globally, normally associated with a high death toll in human and animal populations. These pathogens have shown characteristic speed in their evolutionary processes, enabling rapid host immune evasion and maximizing their propensity for fast spread. Some of these pathogens have shown a high ability for cross-species transmission affecting humans and animals of food security importance, with severe consequences on food security and economic collapse of the individual households and the affected regions (e.g Rift Valley fever virus).
Visualizing the anti-inflammatory cannabinoid Type-2 receptor
Authors: Nazaré Marc , Grether Uwe 
Published: April 2023

Visualizing the anti-inflammatory cannabinoid Type-2 receptor
Medicinal chemists describe how small molecule probes allow for the detection of CB2R, and thereby enable the discovery of novel anti-inflammatory treatments. The G-protein-coupled receptor (GPCR) CB2R (1) is an essential constituent of the endocannabinoid system (ECS), a central lipid signalling system in all vertebrates (2). Preclinical studies have shown that CB2R activation is a general and robust principle to attenuate inflammation and associated tissue injury in a wide variety of pathological conditions. Strong accumulating evidence suggests that diseases such as heart disorders, gastrointestinal, liver, kidney, lung, neurodegenerative or neuroinflammatory diseases, pain, skin pathologies, rheumatoid arthritis, endometriosis and eye diseases might be therapeutically addressable by CB2R (3).
The idea of self-organisation in biology and its critics
Authors: Deichmann Ute 
Published: April 2023

The idea of self-organisation in biology and its critics
Using the example of Alan Turing's paper on morphogenesis, Ute Deichmann at Ben-Gurion University of the Negev explores self-organisation in biology. The availability of large amounts of genomic and other data and the complexity of biological systems have led to increasing collaboration of biologists with mathematicians and computer scientists. However, the use of mathematics in biology differs from that in physics, and problems arise when basic biological principles, such as the genomic control of basic life processes or the specificity of organisms and their biochemistry, are disregarded. I exemplify the importance of mathematics in biology and the problems this can entail, using the example of mathematician and computer scientist Alan Turing's work on morphogenesis, that is, the generation of form in development.