bluuebunny/crossref_metadata_2025_split huggingface dataset:
Providing office-workers with height-adjustable workstation to reduce and interrupt workplace sitting time: Protocol for the Stand Up for Healthy Aging (SUFHA) cluster randomized controlled trial
Authors: Júdice Pedro B. , Silva Hélio , Teno Sabrina C. , Monteiro Patrícia , Silva Marlene N. , Carraça Eliana V. , Santos Inês , Pereira Sara , Luz Filipe , Viegas Patrícia C. , Oliveira Jorge , Santos Isabel F. , Palmeira António L. 
Published: April 2023

Abstract
Background:

Sedentary behavior (SB) has been linked to several negative health outcomes. Therefore, reducing SB or breaking-up prolonged periods of SB improves functional fitness, food consumption, job satisfaction and productivity. Reducing SB can be achieved by introducing a health-enhancing contextual modification promoted by a sit-stand desk in the workplace. The primary goal will be to test the effectiveness of this intervention in reducing and breaking-up SB, while improving health outcomes in office-based workers during a 6-month intervention.

Methods:

A two-arm (1:1), superiority parallel-group cluster RCT will be conducted to evaluate the effectiveness of this intervention in a sample of office-based workers from a university in Portugal. The intervention will consist of a psychoeducation session, motivational prompts, and contextual modification promoted by a sit-stand desk in the workplace for 6 months. The control group will work as usual in their workplace, with no contextual change or prompts during the 6-month intervention. Three assessment points will be conducted in both groups, pre-intervention (baseline), post-intervention, and a 3-month follow-up. The primary outcomes include sedentary and physical activity-related variables, which will be objectively assessed with 24h monitoring using the ActivPAL for 7 days. The secondary outcomes include a) biometric indices as body composition, body mass index, waist circumference and postural inequalities; and b) psychosocial variables such as overall and work-related fatigue, overall discomfort, life/work satisfaction, quality of life, and eating behavior. Both the primary and secondary outcomes will be assessed at each assessment point.

Discussion:

This study will lean on the use of a sit-stand workstation for 6 months, prompted by an initial psychoeducational session and ongoing motivational prompts. We will aim to contribute to this topic by providing robust data on alternating sitting and standing postures in the workplace.
Trial registration: The trial was prospectively registered, and the details are at: https://doi.org/10.17605/OSF.IO/JHGPW; Registered 15 November 2022. OSF Preregistration.
Dienogest alone or dienogest combined with estrogens in the treatment of ovarian endometriomas, that is the question. A retrospective cohort study.
Authors: Forno Simona Del , Orsini Benedetta , Verrelli Ludovica , Caroli Martina , Aru Anna Chiara , Lenzi Jacopo , Raimondo Diego , Arena Alessandro , Borghese Giulia , Paradisi Roberto , Meriggiola Maria Cristina , Seracchioli Renato , Casadio Paolo 
Published: April 2023

AbstractPurposeto compare the effects of Dienogest 2 mg (D) alone or combined with estrogens (D + ethinylestradiol 0.03 mg, D + EE; D + estradiol valerate 1–3 mg, D + EV) in terms of symptoms and endometriotic lesions variations.MethodsThis retrospective study included symptomatic patients in reproductive age with ultrasound diagnosis of ovarian endometriomas. Medical therapy for at least 12 months with D, D + EE or D + EV was required. Women were evaluated at baseline visit (V1) and after 6 (V2) and 12 months (V3) of therapy.Results297 patients were enrolled (156 in the D group, 58 in the D + EE group, 83 in the D + EV group). There were no differences between groups in terms of lesions mean diameter variation. No variations were detected in terms of lesions reduction when comparing the two estroprogestins, cyclic versus continuous estroprogestin regimens, D alone versus D + EE/D + EV administered continuously. When comparing D and D + EE/D + EV groups, a significant decrease of dysmenorrhea was detected in the D group than in D + EE/D + EV group. Conversely, the reduction of dysuria was more significative in the D + EE/D + EV groups rather than in the D group. Regarding tolerability, treatment associated side effects were reported by 16.2% patients. The most frequent one was uterine bleeding/spotting, significantly higher in the D + EV group.ConclusionDienogest alone or associated with estrogens (EE/EV) seems to be equally effective in reducing endometriotic lesions mean diameter. The reduction of dysmenorrhea was more significative when D was administered alone, while dysuria seems to improve more when D is associated with estrogens.
Toxicological effects, residue levels and risks of endocrine disrupting chemicals in Chinese medicine: A review
Authors: Hu Zhiqin , Wu Lixiang , Gan Hongya , Lan Huili , Zhu Bingqi , Ye Xiaoqing 
Published: April 2023

Abstract
Endocrine disrupting chemicals (EDCs), which exist in all aspects of our lives, may interfere with the synthesis, action and metabolism of human sex steroid hormones, resulting in development and fertility problems as well as obesity and the disturbance of energy homeostasis. Traditional Chinese medicine (TCM) that used worldwide possess the satisfactory function of disease prevention, treatment and health care, and this natural medicine seems to be favored due to its low side effects. From planting to processing, TCM may be polluted by various EDCs. Many studies pay attention to this problem, but there are still few reviews on the residues and toxicity risks of EDCs in TCM. In this paper, researches related to EDCs in TCM were screened. The possible contamination sources of TCM from planting to processing and its toxic effects were introduced. Moreover, the residues of metals, pesticides and other EDCs in TCM as well as the health risks of human exposure to EDCs through ingestion of TCM materials were reviewed.
The Role of Military Service in Preventing Depression in China: Evidence from a Nationally Representative Longitudinal Survey
Authors: Li Haoran , Zhang Ning , Zhang Jingya , Liu Jinnan , He Rongxin , Jiang Yufei , Mao Ying , Zhu Bin 
Published: April 2023

Abstract
Background: Despite recognition in the West that military veterans experience more mental health issues than the general population, little research has focused on this subject in China. This study examined the associations between male veterans’ military experience and depressionin China.
Methods: A sample of 12,914 men including 669 veterans was included in the final analysis and propensity score matching, multivariable regressions were used.
Results: The military experience was associated with a lower likelihood of depression in male veterans. In the subgroup analysis, military experience was associated with a lower likelihood of depression among married and urban male veterans. Military experience was also associated with a lower likelihood of depression in both “junior college and above” and “below junior college” groups. In contrast, evidence was lacking regarding the associations between military experience and depression for unmarried and rural veterans.
Conclusions: Individual characteristics could influence the relationship between military experience and depression in male veterans, and the mental health of veterans should be paid more attention and guaranteed.
Monocyte count and systemic immune-inflammation index score as predictors of delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage
Authors: Lee Yeonhu , Song Jihye , Lim Yong Cheol 
Published: April 2023

Abstract
Objective
Delayed cerebral ischemia (DCI) is a major cause of disability in patients who survive aneurysmal subarachnoid hemorrhage (aSAH). Systemic inflammatory markers, such as peripheral leukocyte count and systemic inflammatory index score, have been suggested as predictors of DCI in previous studies. Here, we investigated which systemic biomarkers are significant predictors of DCI.
Methods
This was a retrospective, cohort, single-center study of 170 patients with SAH admitted between May 2018 and March 2022. We analyzed the patients’ clinical and laboratory parameters within 1 h and 3–4 and 5–7 days after admission. The patients were divided into DCI and non-DCI groups, and univariate and multivariate logistic regression analyses were conducted to identify significant predictors of DCI.
Results
The univariate logistic regression analysis revealed that Hunt–Hess grade “4–5” at admission, modified Fisher scale grade “3–4” at admission, hydrocephalus, intraventricular hemorrhage, and infection were significantly associated with DCI (P < 0.05). Among the laboratory parameters,Lymphocyte and monocyte counts at admission, systemic inflammatory index scores and C-reactive protein levels on days 3–4, and leukocyte and neutrophil counts on days 5–7 were significantly associated with DCI (P < 0.05). Multivariate logistic regression analysis identified monocyte count at admission (odds ratio [OR] = 1.64; 95% confidence interval [CI], 1.04–2.65; P = 0.036) and systemic inflammatory index score on days 3–4 (OR = 1.55; 95% CI, 1.02–2.47; P = 0.049) as independent predictors of DCI.
Conclusions
Our findings indicate that monocyte count at admission and systemic inflammatory index score on 3–4 days after aSAH are independent predictors of DCI. These biomarkers could potentially be used to identify patients at high risk of developing DCI.Peripheral monocytosis may be the primer for the innate immune reaction, and the systemic inflammatory index score at days 3–4 can promptly represent the propagated systemic immune reaction toward DCI.
Hepatoblastoma – an institutional experience of this rare malignancy in children
Authors: Mehta Naimish N , Solanki Sanket , Kalra Manas , Das Sri Aurobindo Prasad , Sachdeva Anupam , Nundy Samiran 
Published: April 2023

Abstract
Introduction: Hepatoblastoma is a common malignant liver tumour in children with a peak incidence in the first two years. Its previous mortality was reported to be 24%, but refinements in risk stratification, advances in chemotherapy and application of protocol-based therapy including surgery have resulted in improving long-term outcomes.
Methods: We describe our experience of children with hepatoblastoma using the new treatment guidelines who underwent surgery between January 2013 and December 2020
Results: During the aforementioned period, 6 patients with hepatoblastoma (4 male and 2 female) were treated in our unit with median age at presentation being 15 (range 6 – 36) months. One patient was PRETEXT stage I, three were stage II and two were stage III. All of them had chemotherapy prior to surgical resection as per the SIOPEL-3 and SIOPEL-4 protocols varying between 2-4 cycles following which size reduction in the tumors was noted. right hepatectomy in three patients, non-anatomical hepatic resection in one, left lateral hepatectomy in one and left hepatectomy in one. The mean duration of surgery was 205 (range 115- 300) minutes and the mean blood loss was 50 (range 20-150) ml. There was no operative mortality following which all patients then had adjuvant chemotherapy and are alive with a median follow-up of 40.6 (18-104) months.
Conclusion: The management of hepatoblastoma has changed significantly following the incorporation of recent updates from international groups into clinical practice. With the use of risk stratification, preoperative and adjuvant chemotherapy, and surgical excision, the overall and event-free survival has improved, reiterating the value of a multidisciplinary approach towards the treatment of this disease.
Geometrically nonlinear inerter for vibration suppression
Authors: Song Yuyang , Chen Liqun , Yang Tianzhi 
Published: April 2023

Abstract
In this paper, a geometrically nonlinear inerter (NI) device consisting of two inerters with a designed configuration is presented. Such a device is integrated in an inertial nonlinear energy sink (INES), and we examine its vibration suppression performance using the Runge-Kutta (RK) method, which is verified by the harmonic balance method (HBM). The new isolator is compared to a traditional vibration isolator, and the results show a significant improvement in vibration suppression performance. To investigate the effects of different excitation amplitudes and initial conditions on the dynamics of the system, a series of transmissibility-frequency response analyses are performed by defining the displacement transmissibility. These analyses are carried out at frequencies near the natural frequency. The energy flow of the system is analyzed, and numerous calculations reveal a series of ideal values for the energy sink in the NI-INES system. This study provides new insights for the design of vibration isolators.
Molecular Diagnosis of Chagas Disease: A Systematic Review and Meta-Analysis.
Authors: Pascual-Vázquez Guillermo , Alonso-Sardón Montserrat , Rodríguez-Alonso Beatriz , Pardo-Lledías Javier , Romero-Alegría Ángela , Fernández-Soto Pedro , Muñoz-Bellido Juan Luis , Muro Antonio , Belhassen-Garcia Moncef 
Published: April 2023

Abstract
Background: There is no consensus regarding the most effective molecular protocol for the diagnosis of Chagas disease. The diagnostic tools for Chagas disease are controversial within the scientific community. Currently, serology is the reference standard technique; occasionally, results are inconclusive, and a different diagnostic technique is needed. Some guidelines recommend molecular testing. A systematic review and meta-analysis of available molecular tools/techniques for the diagnosis of Chagas disease was performed to measure their heterogeneity and efficacy in detecting Trypanosoma cruzi infection in blood samples.
Methods: A systematic review was conducted up to July 27, 2022, including studies published in international databases. Inclusion and exclusion criteria were defined to select eligible studies. Data were extracted and presented according to PRISMA 2020 guidelines. Study quality was assessed using Quality Assessment of Diagnostic Accuracy Studies-2 (QUADAS-2). A random-effects model was used to calculate pooled sensitivity, specificity, and diagnostic odds ratio (DOR). Forest plots and a summary of the receiving operating characteristics (SROC) curves displayed the outcomes. Heterogeneity was determined by I2 and Tau2 statistics and p values. Funnel plots and Deek's test were used to assess publication bias. A quantitative meta-analysis of the different outcomes in the two different clinical phases was performed.
Principal findings: We identified 858 records and selected 32 papers. Studies pertained to endemic countries and nonendemic areas with adult and paediatric populations. The sample sizes ranged from 17 to 708 patients. There were no concerns regarding the risk of bias and applicability of all included studies. This resulted in high heterogeneity between studies, with the master mix origin and guanidine addition representing significant sources.
Interpretation/Conclusions and relevance: Continuous analysis and optimization of the different molecular techniques is crucial to implement this efficient diagnosis in endemic areas.
Optimizing the roles of health workers to improve access to health services in Africa: an implementation framework for task shifting and sharing for policy and practice
Authors: Okoroafor Sunny C , Christmals Christmal Dela 
Published: April 2023

Abstract
Background: Globally, countries are taking actions to ensure that their population have improved access to people-centred and integrated health services. Attaining this requires improved access to health workers at all levels of health service delivery and equitably distributed by geographical location. Due to the persistent health worker shortages, countries have resorted to implementing task shifting and task sharing in various settings to optimally utilize existing health workers to improve access to health services. There are deliberations on the need for an implementation framework to guide the adoption and operationalization of task shifting and task sharing as a key strategy for optimally utilizing the existing health workforce towards the achievement of UHC. The objective of this study was to develop an implementation framework for task shifting and task sharing for policy and practice in Africa.
Methods: A sequential multimethod research design supported by scoping reviews, and qualitative descriptive study was employed in this study. The evidence generated was synthesized into an implementation framework that was evaluated for applicability in Africa by 36 subject matter experts.
Results: The implementation framework for task shifting and task sharing has three core components – context, implementation strategies and intended change. The implementation strategies comprise of iterative actions in the development, translation, and sustainment phases that to achieve an intended change. The implementation strategies in the framework include mapping and engagement of stakeholders, generating evidence, development, implementation and review of a road map (or action plan) and national and/or sub-national policies and strategies, education of health workers using manuals, job aids, curriculum and clinical guidelines, and monitoring, evaluation, reviews and learning.
Conclusion: The implementation framework for task shifting and task sharing in Africa serves as a guide on actions needed to achieve national, regional and global goals based on contextual evidence. The framework illustrates the rationale and the role of a combination of factors (enablers and barriers) in influencing the implementation of task shifting and task sharing in Africa.
Status and associations of transition shock among nursing students during clinical practice: a cross-sectional study
Authors: Tang Yinying , Chen Xiuwen , Liao Yuying , Zheng Tingyu 
Published: April 2023

Abstract
Background

Transition shock experienced by nursing students during their clinical practicums is a relevant and worrying issue, which will affect their adaptability to work and future development. However, little is known about influencing factors of transition shock for nursing students.

Objectives

To investigate the status quo of transition shock among nursing students, and to discover its influencing factors in the transition process.

Design: A

cross-sectional descriptive survey.

Setting:

The survey was carried out at four tertiary A hospitals in Changsha, Hunan province, which is located in south-central China.

Participants:

In November 2022, a total of 620 full-time nursing students were investigated by convenient sampling, and 564 valid questionnaires were recovered in this study.

Methods

Sociodemographic information of students were collected. The Transition Shock Scale was used to evaluate students' transition shock level.

Results

The average of the overall score of the Transition Shock Scale was 46.67 ± 8.99. Attitude towards nursing has significant impact on influencing students' transition shock (p ＜ 0.05). Additionally, the number of night shift, whether chose nursing as first choice or not, whether being class leaders or not, education level, future plan, school scale, monthly household income also contributed to different dimensions of transition shock (p ＜ 0.05).

Conclusions

The transition shock of nursing students was at medium level. The transition shock influencing factor of them was their attitude towards nursing. Therefore, administrators in clinical practice should pay attention to the impact of the transition shock and take reasonable intervention measures to enhance the positive impact of the attitude towards nursing on transition and help nursing students successfully complete the transition.
Experimental study of underwater operation scene with target perception framework
Authors: GAO JUE , Ding Wei , YANG HAIPING 
Published: April 2023

Abstract
This paper proposes a target perception framework to explore information on underwater operation scene, for assisting the operation and ensuring the safety of the diver. The framework adopts a layered processing mechanism including water column imaging, constant false alarm rate detection (CFAR) detection and local feature analysis. To simulate the underwater operation scene of the diver, experiments under three fields of view are designed: fixed view of the down-looking, fixed view of the front-looking, and mobile view of the side-looking. The experimental results show that the target perception framework can accurately distinguish false targets, static targets, and dynamic targets in the underwater operation scene, and obtain the motion trajectory of dynamic targets. Moreover, the approximate stereoscopic contour of the diver and bubble groups can be drawn by 3D reconstruction of underwater scene data.
A niche-based theory of Island Biogeography
Authors: Beaugrand Gregory , Kléparski Loick , Luczak Christophe , Goberville Eric , Kirby Richard R 
Published: April 2023

Abstract

The Equilibrium Theory of Island Biogeography (ETIB) is a widely applied dynamic theory proposed in the 1960s to explain why islands have coherent differences in species richness. The development of the ETIB was temporarily challenged in the 1970s by the alternative static Theory of Ecological Impoverishment (TEI), which suggests that the number of species on an island is determined by its number of niches or habitats. With no clear evidence relating species richness to the number of niches however, the TEI has been almost dismissed as a theory in favour of the original ETIB. Here, we show that the number of climatic niches on islands is an important predictor of the species richness of plants, herpetofauna and land birds, and we therefore propose a model called the Niche-based Theory of Island Biogeography (NTIB) that successfully, merges the ETIB and TEI into a unifying concept. To account for greater species turnover at the beginning of colonisation, we include higher initial extinction rates. When we test our NTIB for resident land birds in Krakatau Islands it reveals a good correspondence with observed species richness, immigration and extinction rates. We estimate that current species richness at equilibrium is ~48 species (range between 47.76 and 51.36) provided the environmental regime remains unchanged.
3-year Follow-up of a Prospective, Multicenter Study of the Amplatzer Piccolo™ Occluder for Transcatheter Patent Ductus Arteriosus Closure in Children ≥700 grams
Authors: Morray Brian , Sathanandam Shyam , Forbes Thomas , Gillespie Matthew , Berman Darren , Armstrong Aimee , Shahanavaz Shabana , Jones Thomas , Rockefeller Toby , Justino Henri , Nykanen David , Weiler Courtney , Gutfinger Dan , Zahn Evan 
Published: April 2023

Abstract
Objective
This study describes 3-year follow-up of 200 infants weighing ≥700 grams who underwent transcatheter patent ductus arteriosus (PDA) closure with the Amplatzer Piccolo™ Occluder.
Study Design
Between June 2017 and February 2019, 200 children were enrolled in this U.S. study (NCT03055858). Patients were evaluated for PDA closure, survival, and device- or procedure-related events for 3-years post-implant.
Results
The implant success rate was 95.5% (191/200). At 3 years, PDA closure was observed in 100% (33/33) of patients. Overall survival was >95% with 9 reported deaths. No deaths were adjudicated as device- or procedure-related. Notable events included aortic obstruction (2) requiring stent placement and increased tricuspid regurgitation (5). No intervention was required for tricuspid valve regurgitation.
Conclusions
This follow-up study demonstrates high rates of PDA closure, low complication rate, and survival >95% at 3 years. The Amplatzer Piccolo™ Occluder is a safe and effective therapy for PDA treatment in premature infants.