bluuebunny/crossref_metadata_2025_split huggingface dataset:
On Zagreb coindices and Mostar index of TiO2 nanotubes
Authors: Imran Muhammad , Malik Mehar Ali , Aslam Gul I Hina , Ali Amjad , Aqib Muhammad 
Published: February 2023

Abstract
Topological indices have played an important role in predicting physico-chemical properties of chemical compounds. Degree-based topological indices have been proved to have good correlation with boiling points, strain energy, entropy and a number of other properties of compounds.In this paper, we calculate some degree-based indices and conindices of titania nanotubes TiO2.
Psoralidin inhibits osteosarcoma function by downregulating ITGB1 expression via the FAK and PI3K/Akt signaling pathways
Authors: Cheng Shengwen , Liu Senrui , Chen Bowen , Du Chengcheng , Xiao Pengcheng , Luo Xuefeng , Wei Li , Lei Yiting , Zhao Chen , Huang Wei 
Published: February 2023

Abstract
Background
Psoralea corylifolia is a medicinal leguminous plant that has long been used to treat various diseases. Psoralidin (PSO) is the main extract compound of P. corylifolia and exhibits antibacterial, antitumor, anti-inflammatory, antioxidant, and other pharmacological activities. PSO has demonstrated inhibitory effects in several cancers; however, its inhibitory effect on osteosarcoma has not been reported. This study aimed to evaluate the inhibitory effect of PSO on osteosarcoma and elucidate the underlying molecular mechanisms.
Methods
Crystal violet, CCK8, and EdU staining assays were used to assess the inhibitory effect of PSO on the proliferation of 143B and MG63 osteosarcoma cells. Wound healing and Transwell assays were conducted to evaluate the effects of PSO on osteosarcoma cell migration and invasion. The cell cycle and apoptosis were analyzed using flow cytometry. To determine the possible molecular mechanisms, RNA-sequencing was performed and protein expression was analyzed by western blotting. The inhibitory effect of PSO on osteosarcoma in vivo was analyzed using a mouse model of orthotopic osteosarcoma and immunohistochemistry.
Results
PSO inhibited osteosarcoma cell proliferation in a concentration-dependent manner, inhibited cell migration and invasion, and induced cell-cycle arrest and apoptosis. Mechanistically, PSO treatment significantly inhibited the focal adhesion kinase (FAK) and phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathways by downregulating ITGB1 expression in both MG63 and 143B cells. Furthermore, we demonstrated that PSO restrained osteosarcoma growth in vivo.
Conclusion
PSO may suppresses osteosarcoma via the FAK and PI3K/Akt signaling pathways by downregulating ITGB1 expression.
Association between grip strength and depression in Chinese older adults: A cross-sectional analysis from the China Health and Retirement Longitudinal Study
Authors: Wang huan , Shi Guangqing , Zhenliang Xiao , Zhou Jin 
Published: February 2023

Abstract
Background
An increasing evidence exists of an association between grip strength and depressive symptoms. Grip strength and depression are associated with hospitalization rates in the older adults. Our primary goal is to ascertain the relationship between grip strength and depression among adults aged 60 years and above. The following data are quoted from the China Health and Retirement Longitudinal Study(CHARLS).
Method
The quoted data were from wave 3 (2015) of the CHARLS, which included 4,689 older adults (aged ≥ 60 years). Depressive symptoms were assessed using the 10-term Center for Epidemiologic Studies Depression Scale (CES-D). Grip strength was measured in kilograms using a handheld dynamometer (WCS-100; Nantong, China). Multivariate logistic regression was used to estimate the relationship between hand grip strength and depression in the four models.
Results
Participants were community-dwelling older adults (N = 4,689; 79.0% females, 21.0% males) aged ≥ 60 years. Handgrip strength was negatively associated with depressive symptoms (P = 0.000) after adjusting for covariates. However, no significant correlation was noted between BMI, smoking, drinking, and depressive symptoms (P > 0.05).
Conclusion
Grip strength was negatively associated with depressive symptoms in a large sample of older adults in China. Future research is required to further explore the causal relationship between grip strength and depression and determine effective grip strength and depression interventions to improve the quality of life in older people.
Psychometric Research in Creating a Decision Support Tool to Prevent Community Acquired Pressure Injuries for Use in the Spinal Cord Injury Clinic
Authors: Burkhart Lisa , Siddiqui Sameer , Smith Autumn , Richardson Michael , Zachow Karin , Chua Walter , Weaver Frances , Skemp Lisa , Kiefer Amy , LaVela Sherri , Bates-Jensen Barbara 
Published: February 2023

Abstract
Study Design:
Psychometric; Concept Mapping, Delphi Technique
Objectives
Describe the development and validation of a decision support tool to prevent community-acquired pressure injuries (CAPrIs) in individuals with spinal cord injury (SCI) for use in SCI clinics, called the Community-Acquired Pressure Injury Prevention-Field Implementation Tool (CAPP-FIT).
Setting:
Veteran Health Administration Hospital, Chicago, Illinois, USA
Methods
Concept mapping of current pressure injury (PrI) guidelines and qualitative research describing risks, actions, and resources needed to prevent CAPrIs associated with SCI were used to develop 14 veteran checklist items (Items) along with 11 associated provider actions (Actions) for the tool. The Delphi technique was used to validate Items and Actions with a panel of interprofessional SCI providers (n = 15), veterans with SCI (n = 4), and caregivers (n = 3) to determine consensus on a 4-point Likert scale (strongly agree–strongly disagree) for each Item and Action. A 75% agreement was set for responses rated as strongly agree or agree.
Results
Panelists were 60% female, 65% Black, 30% wound care certified with a mean age of 59 years. Two survey rounds were required for consensus. Response rate was 95% for both rounds. Delphi round 1 showed all Items and Actions affirmed agreement above 75% with comments requiring a second round reaching 83% agreement. The CAPP-FIT includes a 14-item computerized Veteran survey and generates a Provider report of veteran responses with recommended actions to guide provider decision-making.
Conclusions
The CAPP-FIT achieved face and content validity for accuracy, usability and acceptability by veterans living with SCI, caregivers, and SCI providers.
An analysis of the distribution of cancer centers in Brazil
Authors: Borrelli Guilherme Querido de Queiroz Ferreira , Bonometto Juliana Vieira Biason , Cubero Daniel de Iracema Gomes , Giglio Auro del 
Published: February 2023

Abstract
Background
The diagnosis and treatment of cancer are complex and necessitate quaternary centers, which require technology and investment. To better serve the population, such centers should be distributed equitably among the states and according to demand. Even with public policy favoring an increase in the number of oncology centers in Brazil, it is necessary to verify the distribution of these centers, as they have a key role in the population’s access to cancer treatment. However, there are few studies evaluating this distribution in the literature.
Objective
To verify whether the distribution of the oncology network in Brazil meets the needs of each state.
Method
This is a descriptive study with data from official federal sources made available by the National Cancer Institute (Instituto Nacional do Câncer-INCA), Department of Informatics of the SUS, Ministry of Health, National Commission of Nuclear Energy (CNEN) and the Brazilian Institute of Geography and Statistics (IBGE). New cancer cases projected for 2020 were compared with data on the number and distribution of radiotherapy centers and highly complex oncology centers (CACON/UNACON) in each state. The Municipal Human Development Index (MHDI) was used to estimate the population’s access to health care in the states, along with gross domestic product (GDP), which was used to calculate the wealth of each state.
Results
In 2020, there were 386 CACON/UNACONs and 267 radiotherapy centers in Brazil, and 65.5% of the CACON/UNACONs and 66.7% of the radiotherapy centers were concentrated in five states (SP, RJ, MG, PR, RS). Of the cancer cases projected for 2020, 59.6% are concentrated in these five states. Among the states with lower GDP and lower education, there are three with a high number of anticipated cases for each CACON/UNACON (PB, SE and PI) and three with a high number of such cases for radiotherapy centers in PI, PB, RN); RR and AP do not have radiotherapy centers.
Conclusion
It can be concluded that the distribution of oncology centers is not equitable among the states because among the poorest states, there is a smaller number of centers for a greater number of cases.
A comparative study of locking plate combined with minimally invasive plate osteosynthesis and intramedullary nail fixation in the treatment of Neer classification of 2-part and 3-part fractures of the proximal humerus
Authors: Ding Chen , Zhu Ya , Lu Yifeng , Zheng Miaomiao , Nian Shengshen , Tang Hao 
Published: February 2023

Abstract
Objective:To compare the clinical efficacy of minimally invasive locking plate technique (Philos plate) and interlocking intramedullary nailing technique (TRIGEN intramedullary nail) in the treatment of Neer two-part and three-part proximal humeral fractures.
Methods and materials:The clinical data of 60 patients with Neer two-part and three-part proximal humerus fractures admitted to Hospital from April 2017 to April 2020 were retrospectively analyzed. 32 cases were treated with minimally invasive locking plate technique (minimally invasive plate group) and 28 cases were treated with interlocking intramedullary nailing technique (intramedullary nail group). The operation time, intraoperative blood loss, incision length, fracture healing time, and postoperative complications were compared between the two groups. ASES score and Constant-Murley score were used to evaluate the shoulder joint function of the two groups one year after surgery.
Results:All 60 patients were followed up for 12 to 24 months, with an average of 16 months. There was no significant difference in operation time, intraoperative blood loss, incision length and fracture healing time between the two groups (P>0.05). The incidence of postoperative complications in the intramedullary nail group was significantly lower than that in the minimally invasive steel plate group, and the difference between the groups was statistically significant (P<0.05). There was no significant difference in ASES score and Constant-Murley score between the two groups one year after surgery (P>0.05).
Conclusion:The use of minimally invasive locking plate technique and interlocking intramedullary nailing technique in the treatment of Neer two-part and three-part proximal humerus fractures has the advantages of small incision, less blood loss, and high fracture healing rate, and both can achieve satisfactory clinical effects. The internal nail technique is more convenient than the minimally invasive locking plate technique in controlling postoperative complications.
Assessment of the impact of reopening strategies on the spatial transmission risk of COVID-19: A data-driven transmission model
Authors: Wang Jing , Huang YuHui , Dong Ying , Wu BingYing 
Published: February 2023

Abstract
COVID-19 has dramatically changed people’s mobility behavior patterns and affected the operations of different functional sites. In the context of the successive reopening of countries around the world since 2022, it is crucial to understand whether the reopening of different types of locations poses a risk of widespread epidemic transmission. In this paper, by establishing an epidemiological model based on mobile network data, combining the mobile network data provided by Safegraph website, and taking into account the crowd flow characteristics and the changes of susceptible and latent populations, we simulated the trends of the number of crowd visits and the number of epidemic infections at different functional points of interest after the implementation of reopening strategies. Accordingly, the impact of crowd flow changes under different reopening strategies on the risk of epidemic transmission was judged. The model was also validated with daily new cases in ten metropolitan areas in the United States from March to May 2020, and the results showed that the model fitted the evolutionary trend of realistic data more accurately. Further, the points of interest were classified into risk levels, and the corresponding reopening minimum standard prevention and control measures were proposed to be implemented according to different risk levels. The results showed that restaurants and gyms became high-risk points of interest after the implementation of the reopening strategy, especially the general dine-in restaurants were at higher risk. Religious activity centers were the points of interest with the highest average infection rates after the implementation of the reopening strategy. Points of interest such as convenience stores, large shopping malls and pharmacies were at a lower risk for outbreak impact after the reopening strategy was implemented. Based on this, reopening prevention and control strategies for different functional points of interest are proposed to provide decision support for the development of precise prevention and control measures for different sites.
Investigating Autonomic Nervous System Dysfunction among Patients with Post- Covid Condition and Prolonged Cardiovascular Symptoms
Authors: Silva Fernanda Stábile da , Bonifácio Lívia Pimenta , Bellissimo-Rodrigues Fernando , Joaquim Luiz Fernando , Dias Daniel Penteado Martins , Romano Minna Moreira Dias , Schmidt André , Crescêncio Júlio César , Buzinari Tereza Cristina , Fazan Rubens , Salgado Helio César 
Published: February 2023

Abstract
The variability of heart rate (HR) and arterial pressure (AP), and their responses to head-up tilt test (HUTT) was investigated in post-Covid-19 syndrome (PCS) patients, reporting tachycardia and/or postural hypotension. PCS patients were tachycardic and showed attenuation of the following parameters: RMSSD; power of RR spectra at HF; occurrence of 2UV pattern of RR (symbolic analysis); and sample entropy. Basal AP and LF power of systolic AP were similar between PCS patients and control subjects; while 0V patterns of AP were exacerbated in PCS patients. Despite tachycardia and decrease in RMSSD, no parameter changed during HUTT in PCS patients. PCS patients reassessed after 6 months showed higher HF power of RR spectra and higher percentage of 2UV pattern of RR. Moreover, the reassessed PCS patients showed a lower occurrence of 0V patterns of AP, while the HUTT elicited HR and AP responses identical to control subjects. The HR and AP variability suggest an autonomic dysfunction with sympathetic predominance in PCS patients; while the lack of responses of HR and BP variability indices during HUTT indicates a marked impairment of autonomic control. However, the reassessment of PCS patients showed that the noxious effect of the PCS tended to fade over time.
Symptom screening with Targeted Early Palliative care (STEP) versus usual care for patients with advanced cancer: A mixed methods study
Authors: Zimmermann Camilla , Pope Ashley , Hannon Breffni , Bedard Philippe L. , Rodin Gary , Dhani Neesha , Li Madeline , Herx Leonie , Krzyzanowska Monika K. , Howell Doris , Knox Jennifer J. , Leighl Natasha B. , Srid Srikala , Oza Amit M. , Lheureux Stephanie , Booth Christopher M. , Liu Geoffrey , Castro Jacqueline Alcalde , Swami Nadia , Sue-A-Quan Rachel , Rydall Anne , Le Lisa W. 
Published: February 2023

Abstract
Purpose: Although early palliative care is recommended, resource limitations prevent its routine implementation. We report on the preliminary findings of a mixed methods study involving a randomized controlled trial (RCT) of Symptom screening with Targeted Early Palliative care (STEP) and qualitative interviews.
Methods: Adults with advanced solid tumors and an oncologist-estimated prognosis of 6-36 months were randomized to STEP or symptom screening alone. STEP involved symptom screening at each outpatient oncology visit; moderate to severe scores triggered an email to a palliative care nurse, who offered referral to in-person outpatient palliative care. Patient-reported outcomes of quality of life (FACT-G7), depression (PHQ-9), symptom control (ESAS-r-CS), and satisfaction with care (FAMCARE P-16) were measured at baseline and 2, 4, and 6 months. Semi-structured interviews were conducted with a subset of participants.
Results: From Aug/2019 to Mar/2020 (trial halted due to COVID-19 pandemic), 69 participants were randomized to STEP (n=33) or usual care (n=36). At 6 months, 45% of STEP arm patients and 17% of screening alone participants had received palliative care (p=0.009). Nonsignificant trends for all outcomes favored STEP: difference in change scores for FACT-G7=1.67 (95% CI: -1.43,4.77); ESAS-r-CS=-5.51(-14.29,3.27); FAMCARE P-16=4.10(-0.31,8.51); PHQ-9=-2.41 (-5.02,0.20). Sixteen patients completed qualitative interviews, describing symptom screening as helpful to initiate communication; triggered referral as initially jarring but ultimately beneficial; and referral to palliative care as timely.
Conclusion: STEP improves access to palliative care. Despite lack of power, preliminary results are encouraging and qualitative results demonstrate acceptability. Findings will inform an RCT of combined in-person and virtual STEP.
ClinicalTrials.gov Identifier: NCT03987906
Effects of new hypoglycemic drugs on cardiac remodeling: a systematic review and network meta-analysis
Authors: Huang Yi-lin , Xu Xiao-zhuo , Liu Jing , Wang Pin-yao , Wang Xue-li , Feng Hong-lin , Liu Cheng-jiang , Han Xu 
Published: February 2023

Abstract
Background In recent years, the incidence of diabetes mellitus has been increasing annually and cardiovascular complications secondary to diabetes mellitus have become the main cause of death in diabetic patients. Although some novel glucose-lowering drugs have been shown to be cardioprotective, it is unclear which glucose-lowering drugs are effective in improving cardiac remodeling and fundamentally delay the progression of heart failure. The purpose of this network meta-analysis was to compare the effects of sodium glucose cotransporter type 2 inhibitor (SGLT-2i), glucagon-like peptide 1 receptor agonist (GLP-1RA) and dipeptidyl peptidase-4 inhibitor (DPP-4i) on ventricular remodeling in patients with type 2 diabetes (T2DM) and/or cardiovascular disease (CVD).
Methods Articles published prior to 24 August 2022 were retrieved in four electronic databases: PubMed, EMBASE, Cochrane Library, and Web of Science. We included randomized controlled trials (RCTs) and a small cohort study in this meta-analysis. The differences of mean changes of left ventricular ultrasonic parameters between the treatment group and the control group were compared.
Results A total of 31 RCTs and 4 cohort studies involving 4322 patients were analyzed. SGLT-2i had significantly reduced left ventricular end-diastolic diameter (LVEDD) [MD=-0.72ml, 95% CI (-1.30, -0.14)] and LV mass index (LVMI) [MD=-0.28g/m2, 95% CI (-0.43, -0.12)]. GLP-1RA had significantly reduced LV end-systolic diameter (LVESD) [MD=-0.38mm, 95% CI (-0.66, -0.10)], LVMI [MD=-1.07g/m2, 95% CI (-1.71, -0.42)], and e' [MD=-0.43cm/s 95% CI (-0.81, -0.04)]. DPP-4i significantly improved e' [MD=3.82cm/s, 95%CI (2.92,4.7)] and E/e' [MD = -5.97 95% CI (-10.35, -1.59)], but decreased LV ejection fraction (LVEF) [MD = -0.89% 95% CI (-1.76, -0.03)].
Conculusion GLP-1RA were more significantly associated with improvement in LVESD and LVMI, but significantly decreased e'. DPP-4i were more strongly associated with improvement in e' and E/e', but significantly inhibited LVEF. SGLT-2i significantly improved LVMI and LVEDD in the overall population, as well as E/e' and SBP in T2DM patients combined with CVD, without showing any negative effect on left ventricular function. Therefore, we recommend SGLT-2i as the most effective drug for reversing ventricular remodeling.
Remineralization of teeth with Casein Phosphopeptide-Amorphous Calcium Phosphate - Analysis of salivary pH and the rate of salivary flow
Authors: Dashash Mayssoon , Karad Lubna , Alkhouli Muaaz 
Published: February 2023

Abstract
Aim

To evaluate the efficacy of Casein Phosphopeptide-Amorphous Calcium Phosphate (CPP-ACP) in remineralization of teeth of Syrian children aged 6–8 years enrolled in orphanage of the city of Damascus.

Methods

This study is part of a double-blind randomized controlled clinical trial. It included 50 children randomly divided into two treatment groups to receive either CPP-ACP GC Tooth Mousse™ (Group A) or placebo (Group B) with 25 participants per group. After the application of the product in the mouth for 3 minutes, saliva samples were collected four times (T0, T1, T2, and T3) to measure salivary pH and the rate of salivary flow.

Results

There was no significant difference between group A and B in the mean value of salivary flow rate and salivary pH. However, there was a significant difference between different time points in the mean value of salivary pH and salivary flow rate.

Conclusion

The application of the GC Tooth Mouse (CPP-ACP) may not be effective for the remineralization of teeth of children as it was similar to placebo in increasing the salivary pH and salivary flow rate. Other alternatives should be considered.
Trial registration: ISRCTN17509082, Registration date 22/11/2022
Emerging Role of MicroRNA-Based Theranostics in Advanced Hepatocellular Carcinoma
Authors: Toro Abdulhakim Umar , Kurya Abdulaziz Umar , Shukla Sudheesh K. , Bansal Parveen 
Published: February 2023

Abstract
Hepatocellular carcinoma (HCC), with its high mortality and short survival rate, continues to be one of the deadliest malignancies despite relentless efforts and several technological advances. The poor prognosis of HCC and the few available treatments are to blame for the low survival rate, which emphasizes the importance of creating new, effective diagnostic markers and innovative therapy strategies. In-depth research is being done on the potent biomarker miRNAs, a special class of non-coding RNA and has shown encouraging results in the early identification and treatment of HCC in order to find more viable and successful therapeutics for the disease. It is beyond dispute that miRNAs control cell differentiation, proliferation, and survival and, depending on the genes they target, can either promote tumorigenesis or suppress it. Given the vital role miRNAs play in the biological system and their potential to serve as ground-breaking treatments for HCC, more study is required to fully examine their theranostic potential.