bluuebunny/crossref_metadata_2025_split huggingface dataset:
A study to explore the role of a low threshold, fitness focussed physical rehabilitation intervention with protein supplementation to target physical function and frailty in people with problematic substance use and homelessness: protocol for a single-arm feasibility cohort study.
Authors: Kennedy Fiona , Ní Cheallaigh Clíona , Romero-Ortuno Roman , Doyle Suzanne , Broderick Julie 
Published: April 2023

Background: People who are homeless are more likely to experience poor mental health and addiction as well as suffering from non-communicable diseases. There is evidence of frailty and accelerated physical ageing among people experiencing homelessness. Appropriate physical rehabilitation and nutritional supplementation strategies can stabilise or reverse frailty and general physical decline, but it is not known how this type of intervention would work in practice in this population. Aim: To evaluate the feasibility and preliminary efficacy of a low threshold physical rehabilitation intervention with protein supplementation to target physical functioning and frailty in people with problematic substance use who are experiencing homelessness. Methods: The intervention will consist of a 12-week low threshold rehabilitation programme with protein supplementation. Participants will be service users of the Ballyfermot Advance Project, a day services centre for people with addiction issues and experiencing homelessness. Primary outcomes will be feasibility including numbers recruited, retention of participants and number of repeat visits. Any adverse events will be recorded. Secondary outcomes will be strength and muscular mass, physical performance and lower extremity physical function, pain, frailty and nutritional status. Discussion: An immediate impact may be simply a distraction from difficult circumstances and potentially an improvement of physical health of participants, which can be a conduit for the emergence of other positive behaviours and recovery. Longer term, this study will generate preliminary data on which to inform the design of a definitive randomised controlled trial of physical rehabilitation and protein supplementation, if indicated. Ethics and dissemination: Ethical approval was granted by the Faculty of Health Sciences Research Ethics Committee in TCD. Study findings will be disseminated through publication into an international peer-reviewed journal and presented at national and international conferences.
Gender Norms under Socialism and Capitalism: A Historical Examination of Attitudes towards Maternal Employment in the German Democratic Republic and the Federal Republic of Germany
Authors: Kleinschrot Leonie 
Published: April 2023

Research on the Federal Republic of Germany (FRG) in the 1980s shows a high level of congruence between conservative social policy deterring mothers from employment and traditional societal gender norms. In contrast, little is known about whether people in the German Democratic Republic (GDR) agreed with the socialist idea of continuous full-time maternal employment. Based on unexploited GDR data from 1984 and a description of contemporary social policy, this study examines attitudes towards maternal employment, whether they were related to individual preferences for work or children, and their congruence with the socialist policy. The same questions are examined for the FRG using data from 1982.
Results for the GDR indicate that one third of respondents rejected the socialist idea of maternal full-time employment, with individual work preferences being decisive for respondents’ assessments. In the FRG, there was a high degree of agreement with the gender norm of maternal non-employment, with this being dependent on individual preferences for children. These findings complement post-reunification evidence on East-West-differences in gender norms and provide insights into attitudes under Eastern European state socialism.
* This article belongs to a special issue on “Demographic Developments in Eastern and Western Europe Before and After the Transformation of Socialist Countries”.
Unintended Consequences of Advances in Matching Technologies: Information Revelation and Strategic Participation on Gig-Economy Platforms
Authors: Liu Yi , Lou Bowen , Zhao Xinyi , Li Xinxin 
Published: April 2023

Recent years have witnessed significant advancements in matching technologies used to improve the matching between workers and employers requesting job tasks on a gig-economy platform. Although conventional wisdom suggests that technologies with higher matching quality benefit the platform by assigning better-matched jobs to workers, we discover a possible unintended revenue-decreasing effect. Our stylized game-theoretic model suggests that, although a technology’s matching enhancement effect can increase a platform’s revenue, the jobs assigned by the better matching technology can also unintentionally reveal more information about uncertain labor demand to workers, especially when demand is low, and thus unfavorably change workers’ participation decisions, resulting in a revenue loss for the platform. We extend our model to cases in which (1) the share of revenue between workers and platform is endogenous, (2) the matching quality can be improved continuously, (3) the opportunity cost of workers is affected by competition between platforms, and (4) workers compete for job tasks. We find consistent results with additional insights, including the optimal matching quality that a platform should pursue. Furthermore, we examine two approaches to mitigate the potential negative effect of using an advanced matching technology for the platform and find that under certain conditions, the platform can benefit from revealing labor demand or competition information directly to workers. Our results shed light on both the intended positive and unintended negative effects of improvements in matching quality and highlight the importance of thoughtful development, management, and application of matching technologies in the gig economy. This paper was accepted by D. J. Wu, information systems. Supplemental Material: The online appendix is available at https://doi.org/10.1287/mnsc.2023.4770 .
Topical delivery of mupirocin calcium nanostructured lipid carriers using a full-thickness excision wound healing model
Authors: Patil Priyanka V , Menon Mala D , Palshetkar Aparna D , Desai Namita D 
Published: April 2023

Objective: Treatment of contaminated wounds represents a significant challenge in healthcare and there is a need to develop approaches maximising skin retention to maintain therapeutic concentrations of anti-infectives at the wound site. The objective of the present study was to develop and evaluate mupirocin calcium nanolipid emulgels to enhance wound healing performance and patient acceptability. Methods: Nanostructured lipid carriers (NLCs) of mupirocin calcium were prepared by the phase inversion temperature method using Precirol ATO 5 (Gattefosse, India) and oleic acid as lipids and Kolliphor RH 40 (BASF, India) as surfactant and further incorporated into a gel base for topical delivery. Results: The particle size, polydispersity index and zeta potential of mupirocin NLCs were found to be 128.8±1.25nm, 0.283±0.003 and –24.2±0.56mV, respectively. In vitro release studies from developed emulgel showed sustained drug release over 24 hours. Ex vivo drug permeation studies through excised rat abdominal skin showed better skin permeation (1712.38±15. 57μg/cm2) from developed emulgel compared to marketed ointment (827.92±21.42μg/cm2) after 8 hours, which was in agreement with in vitro antibacterial activity. Studies on Wistar rats indicated the nonirritant potential of developed emulgels. Further, mupirocin emulgels showed improved efficacy in percent wound contraction of acute contaminated open wounds in Wistar rats using a full-thickness excision wound healing model. Conclusion: The emulgels of mupirocin calcium NLCs appear to be effective in the treatment of contaminated wounds due to increased skin deposition and sustained release, thereby enhancing the wound healing potential of existing molecules.
Station Aridity in Weather Monitoring Networks: Evidence from the Oklahoma Mesonet
Authors: Singh Aseem , Taghvaeian Saleh , Mirchi Ali , Moriasi Daniel N. 
Published: April 2023

HighlightsStation aridity can cause overestimation of ETref at weather monitoring networks in irrigated areas.Station aridity was demonstrated in a mesoscale weather monitoring network.Station aridity is amplified in water-scarce irrigated areas during droughts.Station aridity should be accounted for to achieve water conservation through weather-informed irrigation.Abstract. Many weather monitoring networks such as the Oklahoma Mesonet provide estimates of reference evapotranspiration (ETref) to facilitate weather-informed irrigation decisions. However, weather stations that collect the required input data to estimate ETref using the widely applied ASCE standardized ETref equation are not typically installed over a reference surface, defined as a large expanse of dense, well-watered, stress-free grass or alfalfa having a specified height, surface resistance, and albedo. The deviation of actual surface conditions in the surrounding environment of the weather stations from the reference condition creates station aridity effects that can lead to overestimation of ETref. Daily hydroclimate datasets for a period of 20 years (2000-2019) were used to evaluate the prevalence and spatiotemporal characteristics of station aridity across the Oklahoma Mesonet. Station aridity was characterized based on mean dew point deviation (MDD = Tmin - Tdew), maximum relative humidity (RHmax), and normalized difference vegetation index (NDVI). Results demonstrate that station aridity is prevalent and highly variable in both space and time across the Oklahoma Mesonet, as it increases from southeast to northwest in the Oklahoma Panhandle. Larger average seasonal MDD (up to 13°C), lower RHmax (e.g., 57%), and lower NDVI (e.g., 0.22) were observed during extreme to exceptional drought of 2011 in western Oklahoma, where a majority of the state’s irrigated agriculture (88%) is located. Spatiotemporal patterns of station aridity demonstrate the profound effect of wet and dry periods that influence the utility of ETref estimates to improve agricultural water conservation during high irrigation requirement times in water-scarce irrigated areas. Keywords: Evapotranspiration, Irrigation requirement, Reference condition, Station aridity, Weather station.
Recognition and Location of Pepper Picking Based on Improved YOLOv5s and Depth Camera
Authors: Liu Sixing , Liu Mingmiao , Chai Yan , Li Shuang , Miao Hong 
Published: April 2023

HighlightsAn improved YOLOv5s deep learning model was used to identify peppers in complex background.The deep-level features on 3D (O-XYZ) coordinate of peppers were extracted using RealSense depth camera.An image database set of pepper in different scenes was established.A pepper recognition and location system were constructed based on improved YOLOv5s network.The proposed method achieved a mean average precision of 95.6% and minimum depth error of 0.001 m.Abstract. In order to investigate the impact of different scenes on the recognition performance and obtain the location information of picking targets, the recognition and location system based on improved YOLOv5s network and RealSense depth camera was constructed in this study. An image database in different scenes was established including light intensity, occlusion and overlap degree of pepper. An improved YOLOv5s deep learning model with bidirectional feature pyramid network (BiFPN) was used for the deep feature extraction and high-precision detection of pepper, and the effects of different scenes on recognition accuracy of the model were studied. The results showed that mean average precision (mAP) of YOLOv5s model reached 0.956, which was respectively 6.1%, 9.3%, 44.4%, and 8.2% higher than that of YOLOv4, YOLOv3, YOLOv2, and Faster R-CNN model. The model had good robustness under daytime and evening scenes with the mAP value higher than 0.9. The detection accuracy of the model in the leaf occlusion scenes was better than that of fruit overlap. The detection error was 0.001m which could not affect the picking positioning precision when the Z value of three-dimensional coordinates (O-XYZ) of pepper was 0.2 m. The improved algorithm can accurately recognize and extract three-dimensional coordinates of pepper, which reduces the calculations by eliminating lots of duplicate and redundant prediction boxes and provides a reference for trajectory planning of pepper picking operation. Keywords: Different scenes, Pepper recognition and location, Picking operation, YOLOv5s.
Balance between the diffraction efficiency and process robustness for plasmonic lithographic alignment technology considering the Fabry–Perot resonator effect
Authors: Song Zhen , Zhang Libin , Yang Shang , Su Yajuan , Wei Yayi , Ye Tianchun 
Published: April 2023

Different from traditional lithography, metal material with high absorptivity and high reflectivity is introduced into plasmonic lithography technology. In particular, a silver/photo resist/silver film stack can form a Fabry–Perot (F-P) resonator structure, which can greatly change the behavior of the light reflection and transmission. Since the silver layer has a strong absorption ability to the alignment probe light with a wavelength of 532 or 633 nm, the quality of the alignment signal is seriously affected. In this paper, a thin film Fourier transfer model is established to quantitatively calculate the amplitude and phase information of the diffraction light with different orders. The results show that the diffraction optical power can be enhanced by the thickness optimization of all film stacks, and the maximum wafer quality (normalized diffraction efficiency) can be increased to 25.7%. The mechanism analysis of alignment signal enhancement is based on the F-P resonator phase oscillation amplification effect. However, it can also bring the reverse of both the power and phase for the alignment probe signal when the thickness fluctuation of the F-P resonator exists, which will be a great challenge for through-the-mask moiré fringe alignment technology. To obtain the optical power distribution of the structure surface and image of moiré fringes, a transfer matrix method is given to point-by-point calculate the incidence and reflection of the probe light in the vertical direction. The finite-difference time-domain method is also used to demonstrate alignment performance. It is proved that the subtle fluctuation of the photoresist thickness can make a huge difference to moiré fringes. A balance between the diffraction efficiency and process robustness can be achieved for plasmonic lithographic alignment technology by controlling the thickness range of the F-P resonator structure. In addition, the metal-insulator-metal structure has excellent thickness sensitivity and is applicable to optical signal detection and material property monitoring.
Less demand on stem cell marker-positive cancer cells may characterize metastasis of colon cancer
Authors: Kaida Takeshi , Fujiyama Yoshiki , Soeno Takafumi , Yokota Mitsuo , Nakamoto Shuji , Goto Takuya , Watanabe Akiko , Okuno Kota , Nie Yusuke , Fujino Shiori , Yokota Kazuko , Harada Hiroki , Tanaka Yoko , Tanaka Toshimichi , Yokoi Keigo , Kojo Ken , Miura Hirohisa , Yamanashi Takahiro , Sato Takeo , Sasaki Jiichiro , Sangai Takafumi , Hiki Naoki , Kumamoto Yusuke , Naitoh Takeshi , Yamashita Keishi 
Published: April 2023

Background
CD44 and CD133 are stem cell markers in colorectal cancer (CRC). CD44 has distinctive isoforms with different oncological properties like total CD44 (CD44T) and variant CD44 (CD44V). Clinical significance of such markers remains elusive.

Methods
Sixty colon cancer were examined for CD44T/CD44V and CD133 at mRNA level in a quantitative PCR, and clarified for their association with clinicopathological factors.

Results
(1) Both CD44T and CD44V showed higher expression in primary colon tumors than in non-cancerous mucosas (p<0.0001), while CD133 was expressed even in non-cancerous mucosa and rather decreased in the tumors (p = 0.048). (2) CD44V expression was significantly associated with CD44T expression (R = 0.62, p<0.0001), while they were not correlated to CD133 at all in the primary tumors. (3) CD44V/CD44T expressions were significantly higher in right colon cancer than in left colon cancer (p = 0.035/p = 0.012, respectively), while CD133 expression were not (p = 0.20). (4) In primary tumors, unexpectedly, CD44V/CD44T/CD133 mRNA expressions were not correlated with aggressive phenotypes, but CD44V/CD44T rather significantly with less aggressive lymph node metastasis/distant metastasis (p = 0.040/p = 0.039, respectively). Moreover, both CD44V and CD133 expressions were significantly decreased in liver metastasis as compared to primary tumors (p = 0.0005 and p = 0.0006, respectively).

Conclusion
Our transcript expression analysis of cancer stem cell markers did not conclude that their expression could represent aggressive phenotypes of primary and metastatic tumors, and rather represented less demand on stem cell marker-positive cancer cells.
Potential contribution of Helicobacter pylori proteins in the pathogenesis of type 1 gastric neuroendocrine tumor and urticaria. In silico approach
Authors: Sánchez Caraballo Andrés , Guzmán Yenny , Sánchez Jorge , Munera Marlon , Garcia Elizabeth , Gonzalez-Devia Deyanira 
Published: April 2023

BackgroundHelicobacter pylorihas been linked to several diseases such as chronic urticaria, gastritis, and type 1 gastric neuroendocrine tumors (type 1 gNET). Although these diseases seem to have different mechanisms, their relationship withH.pylorisuggests a common inflammatory pathway.ObjectiveTo identify potential cross-reactive antigens betweenH.pyloriand humans involved in chronic urticaria and type 1 gNET.MethodsAlignment was carried out among human proteins associated with urticaria (9 proteins), type 1 gNET (32 proteins), andH.pyloriproteome. We performed pairwise alignment among the human andH.pyloriantigens with PSI-BLAST. Modeling based on homology was done with the Swiss model server and epitope prediction with the Ellipro server. Epitopes were located on a 3D model using PYMOL software.ResultsThe highest conserved sequence was found between the human HSP 60 antigen and theH.pylorichaperonin GroEL with an identity of 54% and a cover of 92%, followed by the alpha and gamma enolases and twoH.pyloriphosphopyruvate hydratase, both with an identity and cover of 48% and 96%, respectively. The H/K ATPase (Chain A) showed high identity with twoH.pyloriproteins (35.21% with both P-type ATPase), but with low cover (only 6%). We observed eight linear and three discontinuous epitopes for human HSP 60 and three lineal and one discontinuous epitope for both alpha-enolase and gamma enolase, high conserved withH.pylorisequences.ConclusionSome type 1 gNET antigens shared potential cross-reactive epitopes withH.pyloriproteins, suggesting that molecular mimicry could be a mechanism that explains the relationship between the infection and this disease. Studies evaluating the functional impact of this relationship are needed.
Public safety messaging during super bowl LVI: A pilot study and modified framework
Authors: Cadet Janine , Sutherlin Soraya , Burke Rita V. 
Published: April 2023

ObjectiveThe Super Bowl is one of the most widely attended sporting events and requires proper communication to ensure emergency preparedness for everyone in the city. This pilot study used Super Bowl LVI as a setting to inform future research evaluating the effectiveness of the public health messaging during mass-gathering events.MethodsThis pilot study modifies past theoretical frameworks and research tools to create a novel survey instrument focused on public safety message effectiveness. This survey was sent to all of those that opted-in to the Joint Information Center’s notification platform during Super Bowl LVI.ResultsThe results show that message comprehension, source credibility, and perceived risk might not be associated with proactive behavior for public safety messaging. However, modality preference results showed that individuals might prefer to receive public safety and emergency alerts by text message.ConclusionsFactors that influence proactive response towards public safety messaging might differ from emergency alerts. This pilot study has yielded results from a major mass-gathering event that can be used to understand errors that arise during public health and emergency preparedness and strengthen future disaster planning and research.
Understanding Reproductive Health among Survivors of Paediatric and Young adults (URHSPY) cancers in Uganda: A mixed method study protocol
Authors: Kayiira Anthony , Zaake Daniel , Xiong Serena , Balagadde Joyce K. , Ghebre Rahel , Wabinga Henry 
Published: April 2023

BackgroundAlthough reproductive failure after cancer treatment in children and young adults has been extensively described in high-income countries, there is a paucity of data in low-income settings. In addition, patient, parent, or health worker experiences, perspectives, and attitudes toward the risk of reproductive failure among young cancer patients in these settings are unknown. This study will describe the extent of reproductive morbidity associated with cancer treatment among childhood and young adult cancer survivors in Uganda. In addition, we aim to explore the contextual enablers and barriers to addressing cancer treatment-related reproductive morbidity in Uganda.MethodsThis is an explanatory sequential mixed-method study. The quantitative phase will be a survey among childhood and young adult cancer survivors recruited from the Kampala Cancer Registry (KCR). The survey will utilize a Computer Assisted Telephone Interview (CATI) platform on a minimum of 362 survivors. The survey will obtain information on self-reported reproductive morbidity and access to oncofertility care. The qualitative phase will use grounded theory to explore contextual barriers and enablers to addressing reproductive morbidity associated with cancer treatment. The quantitative and qualitative phases will be integrated at the intermediate and results stage.ConclusionResults from this study will inform the development of policy, guidelines, and programs supporting reproductive health among childhood and young adult cancer survivors.
Cyproheptadine Treatment of COVID-19-Induced Enteritis: Implications for Hyperinflammatory Phase Management
Authors: Weinstock Leonard B. , Reiersen Angela M. , Jain Anshu , Konstantinoff Katerina , James William , Jalali Farid 
Published: April 2023

ABSTRACT
A patient presented with COVID-19-induced enteritis and colitis associated with a high D-dimer. Serotonin released by activated platelets can lead to inflammation and multiorgan failure in COVID-19 infection. Cyproheptadine blocks serotonin receptors. In light of a prior report that showed that cyproheptadine successfully treated neurologic sequelae in COVID-19, we applied this treatment to this patient. Rapid clinical improvement and reduction of D-dimer occurred after 3 doses of cyproheptadine. This inexpensive, well-tolerated, oral medication may be applicable to treat hyperinflammatory sequelae of COVID-19 infection.