bluuebunny/crossref_metadata_2025_split huggingface dataset:
Almond population genomics and non-additive GWAS reveal new insights into almond dissemination history and candidate genes for nut traits and blooming time
Authors: Pérez de los Cobos Felipe , Coindre Eva , Dlalah Naima , Quilot-Turion Bénédicte , Batlle Ignasi , Arús Pere , Eduardo Iban , Duval Henri 
Published: September 2023

Abstract
Domestication drastically changed crop genomes, fixing alleles of interest and creating different genetic populations. Genome-wide association studies (GWASs) are a powerful tool to detect these alleles of interest (and so QTLs). In this study, we explored the genetic structure as well as additive and non-additive genotype–phenotype associations in a collection of 243 almond accessions. Our genetic structure analysis strongly supported the subdivision of the accessions into five ancestral groups, all formed by accessions with a common origin. One of these groups was formed exclusively by Spanish accessions, while the rest were mainly formed by accessions from China, Italy, France, and the USA. These results agree with archaeological and historical evidence that separate modern almond dissemination into four phases: Asiatic, Mediterranean, Californian, and southern hemisphere. In total, we found 13 independent QTLs for nut weight, crack-out percentage, double kernels percentage, and blooming time. Of the 13 QTLs found, only one had an additive effect. Through candidate gene analysis, we proposed Prudul26A013473 as a candidate gene responsible for the main QTL found in crack-out percentage, Prudul26A012082 and Prudul26A017782 as candidate genes for the QTLs found in double kernels percentage, and Prudul26A000954 as a candidate gene for the QTL found in blooming time. Our study enhances our knowledge of almond dissemination history and will have a great impact on almond breeding.
EPERCAS study (Strategies for Preventing Medication Administration Errors in Nursing Homes). Preparation of a list of strategies to prevent the most frequent medication administration errors in the residential care environment
Authors: Laso Lucas Esther , Ferro Uriguen Alex , San Juan Muñoz Adriana E , Ollo Tejero Borja , Beobide Telleria Idoia 
Published: September 2023

AbstractMedication administration errors are one of the most frequent types of errors. There are different safety guides and recommendations to prevent medication errors generally directed to the hospital environment. However, specific recommendations for the management process in the residential care environment are lacking. The main objective of this study was to develop a list of recommendations to aid in preventing the most important medication errors that occur during the administration process in nursing homes (NHs), such as not administering doses or administering medication to the wrong patient. The effectiveness and feasibility of the strategies proposed were evaluated by a panel of experts. The conventional Delphi method was applied. The first round in our study was a face-to-face questionnaire; the second round included an online questionnaire based on the results of the first round. Finally, eight strategies were included in the EPERCAS List: one professional in charge per shift; one professional commissioned by the residential unit; avoid interruptions; avoid medication outside of meal times; personalized medication drawer for each resident including oral medication from a bag and laxatives, inhalers, syrups, eye drops, etc.; identification of the resident and their medication; visual check that everything has been administered; and signature to verify medication administration. The great continual challenge for NH is to define safe and affordable procedures. Minimum safety recommendations for administering the medications, such as those included in this study, should be employed. Our next stage is to implement these strategies in one of our NH and subsequently, evaluate its effectiveness and consider expanding it to the rest of the NH.
A deep dive into the Type II globular cluster NGC 1851
Authors: Dondoglio E , Milone A P , Marino A F , D’Antona F , Cordoni G , Legnardi M V , Lagioia E P , Jang S , Ziliotto T , Carlos M , Dell’Agli F , Karakas A , Mohandasan A , Osborn Z , Tailo M , Ventura P 
Published: September 2023

ABSTRACT
About one-fifth of the Galactic globular clusters (GCs), dubbed Type II GCs, host distinct stellar populations with different heavy elements abundances. NGC 1851 is one of the most studied Type II GCs, surrounded by several controversies regarding the spatial distribution of its populations and the presence of star-to-star [Fe/H], C+N+O, and age differences. This paper provides a detailed characterization of its stellar populations through Hubble Space Telescope (HST), ground-based, and Gaia photometry. We identified two distinct populations with different abundances of s-process elements along the red-giant branch (RGB) and the subgiant branch (SGB) and detected two subpopulations among both s-poor (canonical) and s-rich (anomalous) stars. To constrain the chemical composition of these stellar populations, we compared observed and simulated colours of stars with different abundances of He, C, N, and O. It results that the anomalous population has a higher CNO overall abundance compared to the canonical population and that both host stars with different light-element abundances. No significant differences in radial segregation between canonical and anomalous stars are detected, while we find that among their subpopulations, the two most chemical extremes are more centrally concentrated. Anomalous and canonical stars show different 2D spatial distributions outside ∼3 arcmin, with the latter developing an elliptical shape and a stellar overdensity in the north-east direction. We confirm the presence of a stellar halo up to ∼80 arcmin with Gaia photometry, tagging 14 and 5 of its stars as canonical and anomalous, respectively, finding a lack of the latter in the south/south-east field.
Top incomes and tax policy
Authors: Saez Emmanuel , Zucman Gabriel 
Published: September 2023

Abstract
Modern tax systems do not satisfactorily tax the wealthiest individuals. Meanwhile, government revenue needs have increased in the wake of the COVID-19 pandemic. This paper discusses ideas for new revenue sources focused on the top of the distribution: A progressive tax on net wealth with a high exemption threshold, a wealth tax on corporations' stock and a one-off tax on top-end unrealized capital gains. Given the size and concentration of wealth, the revenue potential of these policies is significant.
RxLR Effectors: Master Modulators, Modifiers and Manipulators
Authors: Wang Shumei , McLellan Hazel , Boevink Petra C. , Birch Paul R. J. 
Published: September 2023

Cytoplasmic effectors with an Arg-any amino acid-Arg-Leu (RxLR) motif are encoded by hundreds of genes within the genomes of oomycete Phytophthora spp. and downy mildew pathogens. There has been a dramatic increase in our understanding of the evolution, function, and recognition of these effectors. Host proteins with a wide range of subcellular localizations and functions are targeted by RxLR effectors. Many processes are manipulated, including transcription, post-translational modifications, such as phosphorylation and ubiquitination, secretion, and intracellular trafficking. This involves an array of RxLR effector modes-of-action, including stabilization or destabilization of protein targets, altering or disrupting protein complexes, inhibition or utility of target enzyme activities, and changing the location of protein targets. Interestingly, approximately 50% of identified host proteins targeted by RxLR effectors are negative regulators of immunity. Avirulence RxLR effectors may be directly or indirectly detected by nucleotide-binding leucine-rich repeat resistance (NLR) proteins. Direct recognition by a single NLR of RxLR effector orthologues conserved across multiple Phytophthora pathogens may provide wide protection of diverse crops. Failure of RxLR effectors to interact with or appropriately manipulate target proteins in nonhost plants has been shown to restrict host range. This knowledge can potentially be exploited to alter host targets to prevent effector interaction, providing a barrier to host infection. Finally, recent evidence suggests that RxLR effectors, like cytoplasmic effectors from fungal pathogen Magnaporthe oryzae, may enter host cells via clathrin-mediated endocytosis. [Formula: see text] Copyright © 2023 The Author(s). This is an open access article distributed under the CC BY-NC-ND 4.0 International license .
A clinical review of obstructive sleep apnea
Authors: Sisson Caroline B. 
Published: September 2023

ABSTRACT
Symptoms of obstructive sleep apnea (OSA) often are overlooked or misinterpreted, but without treatment, patients are at increased risk for potentially life-threatening conditions including stroke and heart failure. Clinician awareness of the risk factors for and treatment of OSA can prevent the development or progression of these complications in patients.
Toward more personalized breast cancer risk assessment
Authors: Sarkis-Tannous Daad , Sukol Roxanne B. , Sullivan Erika 
Published: September 2023

ABSTRACT
Healthcare providers often are uncertain about how best to assess and manage breast cancer risk. Women at average risk wonder when to start mammography and how often to go. Women at increased risk might inquire about genetic testing, MRI screening, and preventive measures. Patients who carry gene mutations face higher stakes and more complex risk management choices, but only some are aware of their status. This article helps clinicians stratify breast cancer risk and discusses a newer genomic test, the polygenic risk score, that may enable more personalized risk management and decision-making.
PFAPA syndrome in children
Authors: Gardner Nathan J. 
Published: September 2023

ABSTRACT
Periodic fever, aphthous stomatitis, pharyngitis, and adenitis (PFAPA) syndrome is, as the name implies, characterized by an extremely regular cycle of fevers that is accompanied by one or more other symptoms such as oral ulcers, pharyngitis, adenitis, tonsillitis, sore throat, cervical adenopathy, and headache. Originally known as Marshall syndrome, PFAPA is most commonly identified in children younger than age 5 years; however, adults may also present with the disease, though they may report additional symptoms. PFAPA is now understood to be a diagnosis of exclusion. Laboratory studies are typically unremarkable except for increases in acute phase reactants such as C-reactive protein. Treatment is primarily supportive and most frequently uses systemic steroids to suppress the inflammatory response. Acute flares are self-limited, and the syndrome typically resolves on its own as the child reaches age 7 or 8 years.
The effect of a point-of-care ultrasound curriculum on PAs in emergency medicine
Authors: Chenevert Laura , Coneybeare Di , Weingart Gabriel , Truong Jimmy 
Published: September 2023

ABSTRACT
To address identified learning gaps among physician associates/assistants (PAs) working with point-of-care ultrasound (POCUS) in our ED, we designed and implemented a longitudinal POCUS curriculum. This curriculum introduced the 12 main POCUS applications for emergency medicine with presession educational assignments and in-person learning sessions. We used the Kirkpatrick framework of evaluation to develop our metrics of measurement. To examine the effect of the curriculum, pre- and postcurriculum surveys were completed and use of POCUS before, during, and after the curriculum period was monitored. Our results showed the curriculum increased confidence and knowledge of POCUS applications and significantly increased the use of POCUS clinically by PAs. Formal, on-the-job POCUS education for postgraduate PAs is a vital adjunct to informal clinical learning for PAs in emergency medicine to gain POCUS skills.
Anterior knee pain in young athletes
Authors: Ziskin Erica Katherine , Carter Kacey Kathleen , Diaz-Parker Sandee , Glick Brian H. 
Published: September 2023

ABSTRACT
Osgood-Schlatter disease (OSD) and Sinding-Larsen-Johansson disease (SLJD) are commonly diagnosed conditions in young, athletic patients who present with anterior knee pain. Despite the familiarity many clinicians have with OSD because of its frequent diagnosis, it does not differ much from SLJD in clinical presentation. Although these diseases generally are self-limiting, diagnostic imaging studies can help clinicians make the correct diagnosis, helping patients avoid progressing to advanced disease states that would require extended rest time, prolonged pain, and potential surgical intervention.
Risk factor modification as a treatment pillar in managing atrial fibrillation
Authors: Knechtel Maureen 
Published: September 2023

ABSTRACT
Atrial fibrillation (AF) is common, with many modifiable and nonmodifiable risk factors contributing to its increasing prevalence. Pharmacologic management and invasive procedures are the mainstays of treatment, but cardiovascular risk modification is overlooked as a key adjuvant treatment strategy. This article describes the clinical effects of implementing a risk factor modification strategy to reduce dysrhythmia load.
HPV vaccination for prevention of head and neck cancer among men
Authors: El Hussein Mohamed Toufic , Dhaliwal Simreen 
Published: September 2023

Abstract:
The incidence of human papillomavirus (HPV)-associated head and neck cancer (HNC) has been rapidly increasing in developed countries, with HPV-associated HNC now accounting for 70% of all HNC cases. An increased incidence has been noted particularly among males. The disparities in HPV vaccine uptake rates and the increasing number of individuals with HPV-associated HNC suggest a lack of public awareness of both HPV sequelae and prevention options. This review highlights the importance of prophylactic HPV vaccination for preventing HPV-associated HNC, particularly in males. Current evidence substantiates the need for gender-neutral HPV vaccination programs and reinforces the recommendations made by the CDC. This article raises awareness of the association between HPV and HNC as well as the effectiveness of HPV vaccination in HNC prevention.
Progress with induction of HIV broadly neutralizing antibodies in the Duke Consortia for HIV/AIDS Vaccine Development
Authors: Haynes Barton F. , Wiehe Kevin , Alam S. Munir , Weissman Drew , Saunders Kevin O. 
Published: September 2023

Purpose of review
Design of an HIV vaccine that can induce broadly neutralizing antibodies (bnAbs) is a major goal. However, HIV bnAbs are not readily made by the immune system. Rather HIV bnAbs are disfavored by a number of virus and host factors. The purpose of the review is to discuss recent progress made in the design and use of immunogens capable of inducing HIV bnAbs in the Duke Consortia for HIV/AIDS Vaccine Development.

Recent findings
New immunogens capable of binding with high affinity to unmutated common ancestors (UCAs) of bnAb B cell lineages have been designed and strategies for stabilization of HIV Env in its prefusion state are being developed. Success is starting to be translated from preclinical studies of UCA-targeting immunogens in animals, to success of initiating bnAb lineages in humans.

Summary
Recent progress has been made in both immunogen design and in achieving bnAb B cell lineage induction in animal models and now in human clinical trials. With continued progress, a practical HIV/AIDS vaccine may be possible. However, host constraints on full bnAb maturation remain as potential roadblocks for full maturation of some types of bnAbs.
Challenges and physiological implications of sarcopenia in children and youth in health and disease
Authors: Mager Diana R. , Hager Amber , Gilmour Susan 
Published: September 2023

Purpose of review
Highlight the controversies and challenges associated with a sarcopenia diagnosis in infants and children and the potential physiological mechanisms contributing to this disorder.

Recent findings
Sarcopenia has been recently identified in infants and children with chronic diseases such as liver, cardiac, gastrointestinal, cancer and organ transplant recipients. However, there is no consensus regarding the definition of pediatric sarcopenia. Different sarcopenic phenotypes (sarcopenia and sarcopenic obesity) have been identified in healthy children and children with chronic disease. Both conditions have been associated with adverse clinical outcomes (e.g. delayed growth, increased hospitalization) in children and youth with chronic disease. The etiology of pediatric sarcopenia is likely multifactorial associated with malnutrition, physical inactivity and altered metabolic environments influencing skeletal muscle mass accumulation and function. Gaps in the literature include the lack of standard tools that should be used for the evaluation of skeletal muscular fitness and body composition in sarcopenia, particularly in infants and young children (<4years).

Summary
Longitudinal evaluation of sarcopenia expression and the underlying physiological and lifestyle factors contributing to pediatric sarcopenia are important to understand to ensure effective rehabilitation strategies can be developed and to avoid the adverse clinical consequences in children.
The association of self-reported symptoms of central sensitization and sleep disturbances in neuropathic pain
Authors: Sachau Juliane , Kersebaum Dilara , Hüllemann Philipp , Adolf Daniela , Kabelitz Maria , Keller Thomas , Freynhagen Rainer , Tölle Thomas R. , Binder Andreas , Baron Ralf 
Published: September 2023

Abstract

Introduction:
Patients with neuropathic pain (NP) report a higher impairment of quality of life and sleep than patients with chronic pain without neuropathic characteristics. These include somatosensory peculiarities like allodynia, a surrogate marker for central sensitization.

Objectives:
This study aimed to investigate the relation between symptoms of central sensitization and sleep disturbances in patients with NP.

Methods:
Within this cross-sectional study, data sets of 3339 patients with chronic NP syndromes (painful diabetic polyneuropathy, n = 543; postherpetic neuralgia, n = 1480) or complex regional pain syndromes (CRPS, n = 1316) were analyzed. Neuropathic pain symptoms were assessed with the painDETECT questionnaire (PD-Q), depression with the Patient Health Questionnaire-9, and sleep impairment with items of the Medical Outcomes Study Sleep Scale in 4 subscales. The association of demographic/clinical data, somatosensory phenotype, depression, and pain intensity with sleep impairment was assessed by unadjusted Spearman correlation analyses and multivariable regression analyses.

Results:
Sleep impairment was observed in all pain aetiologies although with some significant differences in the single sleep items. The intensity of the individual PD-Q items differed to some extent between the 3 pain entities, whereas the PD-Q sum score was similar. Thermal hyperalgesia and burning assessed by the PD-Q were significantly associated with sleep disturbance, adequacy, and quantity but not with sleep somnolence. Only depression and self-reported allodynia had a significant relation to all 4 sleep elements.

Conclusion:
Beside depression, allodynia as a surrogate marker hints to a possible impact of central sensitization on the sleep disruption of patients with NP.
Complications and Failures of Autologous Heterotopic Cranial Bone versus Alloplastic Cranioplasties
Authors: Oberoi Michelle K. , Mirzaie Sarah , Huang Kelly X. , Caprini Rachel M. , Hu Vivian J. , Dejam Dillon , Ge Shaokui , Cronin Brendan J. , Pfaff Miles J. , Lee Justine C. 
Published: September 2023

Background:
Fresh autologous cranial bone graft has traditionally been regarded as the ideal cranioplasty material; however, long-term comparisons of outcomes with modern alloplastic materials are absent in the literature. The authors evaluated complications and failures among cranioplasties performed with fresh, heterotopic, cranial bone graft versus 3 common alloplastic materials.

Methods:
Random-effects meta-analyses of logit-transformed proportions were performed on studies published between 1971 and 2021 to evaluate complications and failures of cranioplasties performed with fresh, autologous, heterotopic cranial bone; polyetheretherketone (PEEK); polymethylmethacrylate (PMMA); or titanium with a mean follow-up of 12 months or more. Generalized mixed model meta-regressions were performed to account for heterogeneity and to evaluate the contributions of moderators to outcomes variables.

Results:
A total of 1490 patients (mean age, 33.9 ± 10.8 years) were included. Pooled, all-cause complications were 6.2% for fresh, heterotopic, autologous cranial bone (95% CI, 2.1% to 17.0%; I
2 = 55.0; P = 0.02), 18.5% for PEEK (95% CI, 14.0% to 24.0%; I
2 = 0.0%; P = 0.58), 26.1% for titanium (95% CI, 18.7% to 35.1%; I
2 = 60.6%; P < 0.01), and 28.4% for PMMA (95% CI, 12.9% to 51.5%; I
2 = 88.5%; P < 0.01). Pooled all-cause failures were 2.2% for fresh autologous cranial bone (95% CI, 0.4% to 10.6%; I
2 = 0.0%; P = 0.45), 6.3% for PEEK (95% CI, 3.2% to 12.3%; I
2 = 15.5%; P = 0.31), 11.4% for titanium (95% CI, 6.7% to 18.8%; I
2 = 60.8%; P < 0.01), and 12.7% for PMMA (95% CI, 6.9% to 22.0%; I
2 = 64.8%; P < 0.01). Meta-regression models indicated that each alloplastic subtype significantly and independently predicted higher complications, whereas titanium and PMMA were significant predictors for all-cause failures compared with autologous bone. All 3 subtypes were predictive of higher cranioplasty failures secondary to infection compared with autologous bone.

Conclusion:
Cranioplasties performed with fresh, autologous, heterotopic cranial bone grafts resulted in lower complication and failure rates compared with alloplastic materials.
Systematic Appraisal of Guidelines for the Diagnosis and Treatment of Choledocholithiasis
Authors: Zhu Shu-Yao , Huang Jie , Li Ying-Jia , Zhou Bo , Zheng Cai-Ying , Sun Da-Li , Fu Yan 
Published: September 2023

Background:
To systematically evaluate the methodological quality of the current up-to-date guidelines pertaining to choledocholithiasis, we conducted a comprehensive analysis of key recommendations and corresponding evidence, focusing on the heterogeneity among these guidelines.

Method:
Systematic searches across various databases were performed to identify the latest guidelines. The identified guidelines, which met the inclusion criteria, underwent evaluation using the Appraisal of Guidelines for Research and Evaluation II (AGREE II) tool. The key recommendations and evidence from the included guidelines were extracted and reclassified using the Oxford Centre for Evidence-Based Medicine (OCEBM) grading system, and the obtained results were analyzed.

Results:
Nine guidelines related to choledocholithiasis were included in this study, out of which 4 achieved an overall standardized score of more than 60%, indicating their suitability for recommendation. Upon closer examination of the main recommendations within these guidelines, we discovered significant discrepancies concerning the utilization of similar treatment techniques for different diseases or different treatment methods under comparable conditions, and discrepancies in the recommended treatment duration. High-quality research evidence was lacking, and some recommendations either failed to provide supporting evidence or cited inappropriate and low-level evidence.

Conclusion:
The quality of guidelines pertaining to choledocholithiasis is uneven. Recommendations for the treatment of choledocholithiasis demonstrate considerable disparities among the guidelines, particularly regarding the utilization of endoscopic retrograde cholangiopancreatography as a treatment method and the management approaches for difficult stone cases. Improvements by guideline developers for these factors contributing to the heterogeneity would be a reasonable approach to further update the guidelines for cholangiolithiasis.