bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Patent Landscape of mTOR and PTEN Targets
Authors: Zhang Hai-long , Li Yongxia 
Published: May 2023

Background:
PTEN and mTOR signaling have many roles, including antiinflammatory,
immunosuppressant and cancer.

Objective:
US patents were retrieved to show the current landscape of the mTOR and
PTEN targets.

Methods:
PTEN and mTOR targets were analyzed by patent analysis. The U.S. granted
patents from January 2003 to July 2022 were performed and analyzed.

Results:
The results showed that the mTOR target was more attractive in drug discovery
than the PTEN target. Our findings indicated that most large global pharmaceutical companies
focused the drug discovery related to the mTOR target. The present study demonstrated
that mTOR and PTEN targets showed more applications in biological approaches
compared to BRAF and KRAS targets. The chemical structures of the inhibitors of the
mTOR target demonstrated some similar features to those of the inhibitors of KRAS targets.

Conclusion:
At this stage, the PTEN target may not be an ideal target subjected to new
drug discovery. The present study was the first one which demonstrated that the group of
O=S=O may play a critical role in the chemical structures of mTOR inhibitors. It was the
first time to show that a PTEN target may be suitably subjected to new therapeutic discovery
efforts related to biological applications. Our findings provide a recent insight into
therapeutic development for mTOR and PTEN targets.
Eco-friendly Biosynthesis of Ag-NPs by Streptomyces griseus with
Anti-Candida albicans and Antitumor Activity
Authors: Abou El-Enain Inas M. , Abed Nermine N. , Helal Eman E. , Abdelkhalek Eman S. , Suleiman Waleed , Safwat Nesreen A. , Yosri Mohammed 
Published: May 2023

Background:
The most significant sexually transmissible fungal disease, semen
candidiasis, is caused by Candida albicans and impacts male reproductive potential. Actinomycetes
are a group of microorganisms that could be isolated from various habitats and
used for the biosynthesis of various nanoparticles with biomedical applications.

Objective:
Testing antifungal activity of biosynthesized Ag nanoparticles versus isolated
C. albicans from semen as well as its anticancer activity versus the Caco-2 cell line.

Methods:
Screening 17 isolated actinomycetes for the biosynthesis of Ag nanoparticle biosynthesis.
Characterization of biosynthesized nanoparticles, testing its anti-Candida albicans,
and antitumor activity.

Results:
Streptomyces griseus was the isolate that identified silver nanoparticles using UV,
FTIR, XRD and TEM. Biosynthesized nanoparticles have promising anti-Candida albicans
with MIC (125 ± 0.8) μg/ml and accelerate apoptotic rate versus Caco-2 cells (IC50 =
7.30 ± 0.54 μg/ml) with minimal toxicity (CC50 = 142.74 ± 4.71 μg/ml) versus Vero cells.

Conclusion:
Certain actinomycetes could be used for the biosynthesis of nanoparticles
with successive antifungal and anticancer activity to be verified by in vivo studies.
Potensi Ekonomi Guwosari Menjadi Kalurahan Mandiri Melalui Maggot
Authors: Annisa Nadya Nurul , Maula Defia Ifsantin 
Published: May 2023

<p>Penelitian ini menganalisis tentang potensi ekonomi Kalurahan Guwosari menjadi Kalurahan mandiri melalui maggot. Kalurahan Guwosari merupakan termasuk dari wilayah Kapanewon Pajangan Kabupaten Bantul. Potensi ekonomi di Kalurahan Guwosari sangat beragam dan terbagi ke beberapa sektor diantaranya : pariwisata, peternakan, pertanian, perikanan dan industri kecil. Penelitian ini berfokus pada sektor peternakan yaitu maggot. Di Guwosari terdapat budidaya maggot yaitu MMJ Maggot guwosari di Jl. Guwosari raya, maka dari itu karena sudah ada kelembagaannya maka ada peluang untuk Kalurahan Guwosari menjadi Kalurahan Mandiri melalui Maggot. Budidaya maggot sendiri merupakan budidaya level rumah tangga dimana setiap orang dapat membudidayakan maggot. Maggot atau belatung merupakan larva dari lalat BSF (Hermetia Illucens, Stratimydae, Diptera). Maggot Black Soldier Fly dapat digunakan sebagai bahan memberi makan ikan dan juga pakan peternakan unggas. maggot bermanfaat untuk mereduksi sampah organik, Sebanyak 1 gram maggot bisa mengkonsumsi 1 kilogram sampah organik dalam waktu 24 jam. Permasalahan yang terjadi adalah belum adanya peternakan Kalurahan yang mewadahi pendistribusian maggot. Pada penelitian ini pendekatan penelitian yang digunakan dalam penelitian ini adalah pendekatan kualitatif dan metode yang digunakan ada 3 (tiga) diantaranya : metode observasi, metode wawancara dan metode dokumentasi.</p>
Analisis Persepsi Maslahah Dalam Melakukan Pembelian Kompulsif
Authors: Sa'diah Zulfatus , Maranti Safika , Retnowati May Shinta 
Published: May 2023

<p align="center"> </p><p align="center"><strong>Abstract</strong></p><p> This study aims to determine the effect of the perception of maslahah on compulsive buying behavior This research is a quantitative research by integrating the dimensions of maslahah perception into the Theory of Planned Behavior (TPB) model. TPB is an integrated model that consists of four predictors of behavior, namely attitudes, subjective norms, perceived behavioral control (PBC), and intentions to behave. Sampling using Purposive Sampling, that is 200 respondents. To measure the variables using the Continuous rate scale. While the data analysis technique used in this research is path analysis using Smart PLS 2.0 (Partial Least Square) software. The results of the study said that the maslahah perception construct had a significant effect on the attitude construct even though it was weak at 5.5%. Which means there are still about 94.5% of the attitude variables are influenced by other factors. Then the attitude construct has a significant effect on the compulsive buying behavior construct of 47.6%, which means that there are still around 52.4% of the variable Compulsive Buying Behavior which can be explained from other factors. While the construct of subjective norms and behavioral control has no effect on compulsive buying behavior. The reason for the rejection of these two hypotheses is thought to be because Muslim communities who have high subjective norms and behavioral control do not change their behavior in compulsive buying to be higher.</p><strong>Keywords:</strong> <em>Maslahah, Compulsive Buying, Theory of Planned Behaviour</em>
Business Feasibility Aspects of Village-Owned Enterprises in Indonesia
Authors: Darmawan Darmawan 
Published: May 2023

This research is the first in an effort to find out the Business Feasibility Aspects of Village-Owned Enterprises (BUM Desa) in Indonesia. This research is very important because the Village Fund of IDR 329 trillion over the last five years has not been able to be maximally utilized by BUM Desa. There are 2,188 BUM Desa not operating and 1,670 BUM Desa that are running but have not yet contributed optimally to driving the village economy. BUM Desa must be revitalized, improving the performance of BUM Desa is important and urgent because Village Funds continue to increase every year. In 2020, the government allocates a budget of IDR 72 trillion. This study seeks the Business Feasibility Aspects of Village-Owned Enterprises (BUM Desa) by using questionnaires and direct field observations throughout Indonesia with a sample expected to represent Java and Outside Java. It was found that there are five aspects that can measure the feasibility of a business in the BUM Desa business unit: Market and Marketing Aspects; Management and Human Resources Aspects; Financial aspect; Business Environment Aspect; and Legal Aspects. The main problem of BUM Desa is in the financial aspect (76,56%) and the aspect of the business environment (73,29%). Meanwhile, the Market and Marketing Aspects; Management and HR Aspects; Legal Aspect have a feasibility score of above 80%. The business feasibility of BUM Desa in Java is better than outside Java. The social and financial business type has a lower feasibility level than other types of business.
The Experiences of Informal Caregivers of People With Dementia in Web-Based Psychoeducation Programs: Systematic Review and Metasynthesis
Authors: Yu Ying , Xiao Lily , Ullah Shahid , Meyer Claudia , Wang Jing , Pot Anne Margriet , Shifaza Fathimath 
Published: May 2023

Background
Informal caregivers of people living with dementia experience a higher level of physical and mental stress compared with other types of caregivers. Psychoeducation programs are viewed as beneficial for building caregivers’ knowledge and skills and for decreasing caregiver stress.

Objective
This review aimed to synthesize the experiences and perceptions of informal caregivers of people with dementia when participating in web-based psychoeducation programs and the factors that enable and impede informal caregivers’ engagement in web-based psychoeducation programs.

Methods
This review followed the Joanna Briggs Institute protocol of systematic review and meta-aggregation of qualitative studies. We searched 4 English databases, 4 Chinese databases, and 1 Arabic database in July 2021.

Results
A total of 9 studies written in English were included in this review. From these studies, 87 findings were extracted and grouped into 20 categories. These categories were further synthesized into 5 findings: web-based learning as an empowering experience, peer support, satisfactory and unsatisfactory program content, satisfactory and unsatisfactory technical design, and challenges encountered in web-based learning.

Conclusions
High-quality and carefully designed web-based psychoeducation programs offered positive experiences for informal caregivers of people living with dementia. To meet broader caregiver education and support needs, program developers should consider information quality and relevancy, the support offered, individual needs, flexibility in delivery, and connectedness between peers and program facilitators.
ENHANCEMENT OF THE RELEASE OF CURCUMIN BY THE FREEZE DRYING TECHNIQUE USING INULIN AND NEUSILIN AS CARRIERS
Authors: Al-Taani Bashar , Khanfar Mai , Abu Alsoud Osama 
Published: May 2023

Objective: Curcumin (CUR), the active ingredient in turmeric has been proven to possess many therapeutic activities chiefly as anti-inflammatory and antioxidant. Unfortunately, CUR suffers from low bioavailability and dissolution due to its poor water solubility. The aim of this work was to enhance the dissolution of CUR by converting it into an amorphous form by freeze-drying and using different carriers.
Methods: Different solid dispersions of CUR with Inulin and Neusilin US2 at different ratios using the freeze-drying technique were prepared. The various prepared formulas were characterized using differential scanning calorimetry, X-ray diffraction studies, fourier transform infrared and scanning electron microscopy. Release studies, as well as stability studies of CUR from different formulas, were done.
Results: Formulation containing CUR, Inulin and Neusilin US2 at a ratio of 1:5:1 showed the highest CUR release during dissolution testing. The percent CUR release was 98% in comparison with that of 2% from the reference raw material. Physical stability testing showed that CUR remained in the amorphous state for 3 mo.
Conclusion: Inulin and Neusilin US2 combinations were found to be effective in enhancing the solubility and dissolution rate of CUR, and stabilizing the amorphous form in the prepared solid dispersion.
Legal Protection for Workers who Have Harmed Employers
Authors: Amelia Sonia , Permatadani Ega , Rosida Ida Ayu , Akmaliya Rifda Ayu , Irawan Anang Dony 
Published: May 2023

The purpose of this research is to find out how legal protection for workers has harmed employers so that workers have been laid off. The type of research used in this study is normative research using the nature of the law approach as well as the theoretical point of view from scientific books and journals that function to provide solutions to existing legal problems. The results show that even though Article 164 paragraph (3) of Law Number 13 of 2003 must provide severance pay, award money, and services during the employee's working period and provide compensation. When workers are proven to be unproductive at work or have problems with the detriment of the employer, the employer can take action to terminate the employment relationship with the worker. From there, the Law does not prohibit companies from taking efficiency measures, but these efficiency actions are no longer valid if there are procedures or reasons that are not in accordance with the applicable regulatory requirements. With the existence of Law No. 13 of 2003 concerning Manpower, I hope that it can implement various national instruments that have been ratified, for example labor rights. This ambiguity makes the Indonesian people have to have strong policies and regulations on labor rights regulations, so that they can restore the wheels of Indonesia's slumping economy.
Keywords: Labor; Legal Protection; Termination of Employment.

Abstrak
Tujuan penelitian yakni untuk mengetahui bagaimana perlindungan hukum bagi para pekerja yang telah merugikan pengusaha sehingga sampai para pekerja di PHK. Jenis penelitian yang digunakan dalam penelitian ini adalah penelitian normatif dengan memakai sifat pendekatan Undang-Undang serta sudut pandang teoritis dari buku dan jurnal ilmiah yang berfungsi untuk memberikan solusi terhadap permasalahan hukum yang ada. Hasil penelitian menunjukan bahwa Saat pekerja terbukti tidak produktif dalam bekerja atau memiliki masalah sampai merugikan pengusaha disitu pengusaha bisa mengambil tindakan untuk memutuskan hubungan kerja dengan pekerja. Dari situ Undang-Undang tidak melarang perusahaan untuk melakukan tindakan efisiensi namun tindakan efiensi tersebut menjadi tidak berlaku lagi jika ada prosedur atau alasan yang tidak sesuai dengan syarat peraturan yang berlaku. Adanya Undang-Undang Nomor 13 Tahun 2003 Tentang Ketenagakerjaan saya harap bisa melaksanakan berbagai instrument nasional yang telah diratifikasi contohnya hak hak tenaga kerja. Ketidakjelasan tersebut membuat bangsa Indonesia harus memiliki kebijakan dan peraturan yang kuat atas peraturan hak para tenaga kerja, sehingga bisa mengembalikan roda perekonomian Indonesia yang terpuruk ini.
Kata Kunci: Tenaga Kerja; Perlindungan Hukum; Pemutusan Hubungan Kerja.
ELICITING ACTIVITIES MODEL ON STUDENTS' MATHEMATICAL LITERACY ABILITY
Authors: Sholihah Ummu , Susanti Vera Dewi 
Published: May 2023

The low level of mathematical literacy in Indonesia is caused by the selection of an inappropriate learning model. The purpose of this study is to review various references related to the eliciting activities model and mathematical literacy. The type of research method used is Systematic Literature Review (SLR). Data collection used library research. A literature study was obtained by searching the sites scopus.com, scimagojr.com, and Google Scholar and grouping the data using publish or perish. From the data obtained, 5 articles were selected from international proceedings and articles from reputable journals. Articles will be reviewed and analyzed with supporting references. The results of this study are known that improving students' mathematical literacy skills depends on the learning model provided and how educators can choose an appropriate learning model and apply the learning model properly. The eliciting activities model can also improve mathematical literacy by modifying learning models with various approaches. In addition, teachers also need to pay attention to each step in the eliciting activities model so that learning objectives can be achieved.Rendahnya literasi matematika di Indonesia diakibatkan pemilihan model pembelajaran yang kurang tepat. Tujuan penelitian ini adalah mengulas berbagai referensi terkait model eliciting activities dan literasi matematika. Jenis metode penelitian yang digunakan yaitu Systematic Literature Review (SLR). Pengumpulan data menggunakan studi pustaka.. Studi pustaka diperoleh dengan melakukan search proccess situs scopus.com, scimagojr.com dan google scholar dan pengempokkan data tersebut menggunakan publish or perish. Data yang sudah diperoleh dipilih 5 artikel dari prosiding internasional dan artikel dari jurnal bereputasi. Artikel akan diulas dan dianalis dengan diperkuat referensi pendukung. Hasil penelitian ini diketahu bahwa peningkatan kemampuan literasi matematika siswa bergantung dengan model pembelajaran yang di berikan dan bagaimana pendidik dapat memilih model pembelajaran yang sesuai dan menerapkan model pembelajaran tersebut dengan baik. Model eliciting activities juga dapat meningkatkan literasi matematika dengan memodifikasi model pembelajaran dengan berbagai pendekatan. Selain itu juga guru perlu memperhatikan setiap langkah pada model eliciting activities agar tujuan pembelajaran dapat tercapai.
ANALYSIS OF THE CRITICAL THINKING SKILLS OF CLASS X SMK STUDENTS IN BANDUNG CITY
Authors: Karim Raisya Silvi Abdul , Nurlaelah Elah 
Published: May 2023

This article aims to describe the results of analyzing the critical thinking skills of class X SMK students in Bandung city in solving problems on a system of two-variable linear equations. This type of research is descriptive qualitative. The subjects of this study were six students of class X majoring in business management at one of the SMK in Bandung. The research instrument consisted of five questions about critical thinking skills. The data analysis technique used was a data collection technique with documentation methods in the form of test results and student interviews. The results showed that students’ critical thinking skills were still low, especially in question number 5, which had indicators namely evaluating and considering reliable sources or arguments. From the analysis results, it was concluded that this was caused by 1). Students had difficulty identifying important information and 2). Students had difficulity making mathematical models, so students were unable to solve problems. Penelitian ini dilakukan karena belum ditemukannya penelitian yang menganalisis kemampuan berpikir kritis berdasarkan indikator yang diadopsi dari Joko D.P pada konteks siswa SMK. Kemampuan berpikir kritis sendiri bukanlah menyelesaikan persoalan yang kompleks dengan berbagai macam algoritma tetapi merancang algoritma baru dari situasi yang baru. Keterampilan berpikir kritis berguna dalam kehidupan karena semakin tajam kemampuan berpikir kritis maka semakin baik kemampuan siswa dalam memecahkan masalah. Penelitian ini bertujuan untuk mendeskripsikan hasil analisis kemampuan berpikir kritis siswa kelas X SMK di Kota Bandung dalam menyelesaikan soal sistem persamaan linear dua variabel. Penelitian ini merupakan penelitian deskriptif kualitatif. Sampel dari penelitian ini adalah 6 orang siswa kelas X di SMK Dhyana Sakti Bandung. Instrumen penelitian ini terdiri dari soal tes kemampuan berpikir kritis sebanyak 5 soal, pedoman wawancara dan dokumentasi. Teknik pengumpulan data yang digunakan yaitu melalui tahapan reduksi data, penyajian data dan penarikan kesimpulan . Hasil penelitian menunjukan bahwa kemampuan berpikir kritis siswa masih rendah khususnya pada soal nomor 5 yang memiliki indikator yakni mengevaluasi dan mempertimbangkan sumber terpercaya atau argumen . hal tersebut disebabkan oleh 1). Siswa kesulitan mengidentifikasi informasi penting dari soal cerita sistem persamaan linear dua variabel 2). Siswa kesulitan membuat model matematikanya sehingga siswa tidak mampu menyelesaikan soal.
Hepatitis B infection among hemodialysis patients in Al-Jazirah State: a seroepidemiological survey
Authors: Moglad Ehssan H. O. , Mohammed Hajir E. E. , Ali Hatim T.O. 
Published: May 2023

Abstract
Hemodialysis patients are more susceptible to HBV infection because they have low immunity and can be inflicted through an improperly sterilized machine or through a tainted blood transfusion. A cross-sectional study aimed to study the prevalence of HBV among hemodialysis patients in Aljazeera State, Hospital for Renal Disease and Surgery during the period between March and August 2018. A total of ninety-one blood samples were obtained randomly from hemodialysis patients. The plasma was examined for the presence of HBsAg using a sandwich Enzyme-Linked Immuno-Sorbent Assay (ELISA). Data collected by a structured questionnaire included sociodemographic data such as age, sex, marital status, education level, duration of dialysis, previous HBV vaccination, history of surgical operation, history of jaundice and history of blood transfusion. Detectable marker for HBV infections (HBsAg) were found in 21 (23.1%) patients, while the remaining 70 patients (76.9%) were negative. We noted that education level and a history of jaundice had a significant effect on the seroprevalence of HBV, with a P value <0.05.
The study concluded that HBV infection among hemodialysis (HD) patients is high. So, extensive effort to enroll HD patients in a vaccination programme against HBV is recommended. Moreover, periodically screening for early detection of HBV infection among hemodialysis patients is deemed essential in order to for therapeutic measures to be promptly initiated, and for the prevention and protection of other patients and staff in the hemodialysis unit.
Development of standardization methods of gel with sapropel extract and their validation
Authors: Strus Oksana , Revyatskyy Ivan , Holota Serhii , Gushcha Sergey 
Published: May 2023

Abstract
Humic acids (HA) are important natural compounds that are characterized by a wide range of biological activity and therapeutic impact on different pathological processes. Sapropels are natural healing resources that contain a large amount of HA. The pharmaceutical market of Ukraine needs domestic drugs with dermatotropic action based on natural compounds that have a combined antibacterial, wound healing and anti-inflammatory activity, as well low toxicity.
The aims of the research: standardization of the gel under the conditional name "Saprogel" for use in medicine as a wound-healing and anti-inflammatory agent, development of methods for identification and quantification, as well as their validation.
A linear dependence between the concentration of the total mass fraction of HA on the mass of the sample of aqueous sapropel extract (ASE) with a correlation coefficient of 0.9985 (≥0.9981) was observed, while the angular coefficient of linear dependence (b) was found to be 1.02, with the free member of linear dependence (a) being – 1.66≤2.60. The obtained results show that the method is precise because the value of the relative confidence interval is less than the critical value for the convergence of the results: Δ%=1.27≤1.60 and the criterion of the insignificance of systematic error: δ=0.51. As a result of the quantitative analysis, we found that the total mass fraction of HA in the gel samples from the wind farm is 1.302%.