bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enhanced Recovery After Surgery (ERAS) Protocol on Urogynecological Surgeries: 3 years of follow-up after implementation
Authors: Marquini a-Gisele Vissoci , Marra Juliana Marques , Samper Isabela Correa , Abreu Laura Aparecida Xavier , Anelvoi Rafaela Pereira , Alves Tania de Fatima , Marquini Emerson Ricardo , Pinto Rogério de Melo Costa , Uyeda i-Maria Gabriela Baumgarten Kuster , Sartori Marair Gracio Ferreira 
Published: January 2023

Abstract
Introduction. The Enhanced Recovery After Surgery (ERAS) protocol for perioperative care recommends positive interventions to accelerate postoperative recovery, such as preoperative fasting abbreviation and prevention of thrombosis. Although applied in other surgical areas, data on its recommendations in urogynecological surgeries are scarce. The aim of this study was to evaluate the plausibility, reproducibility and impact of implementation of the main ERAS recommendations (preoperative fasting abbreviation and prevention of thrombosis) on urogynecological surgeries, in medical practice.
Methods. After approval by ethics committee and signature of the free and informed consent form by the patients, a purely observational study was carried out under abbreviation for preoperative fasting with 400 ml of clear liquid enriched with carbohydrate and protein 4 hours and thromboprophylaxis approaches in urogynecological surgeries, from 2015 to 2019 in a medium complexity hospital, with analysis of parameters such as thrombotic events, length of stay and patient satisfaction on recovery after surgery.
Results.Of 280 elective surgeries with abbreviation for preoperative fasting, the most frequent urogynecological procedures were: 85 (24.42%) posterior colpoplasties, 67 (19.25%) minor labioplasties and 36 (10.34%) midurethral slings. For venous tromboembolism prophylaxis subcutaneous enoxaparina (0,5mg/Kg) was used in 170 (60.07%) patients at moderate risk for thrombosis and mechanical measures for those at low risk, without thromboembolic complications. Mean hospitalization time was of one day.
Conclusions. According to this study, abbreviation of preoperative fasting as described and thromboprophylaxis from ERAS recommendations were plausible, reproducible in medical practice and can be stimulated in urogynecological surgeries to accelerate the postoperative recovery.
Additional single dose GnRH agonist during luteal phase support may improve live birth rate in GnRHa-HRT frozen–thawed embryo transfer cycle: a retrospective cohort study
Authors: Chang Wei-Shan , Lin Pei-Hsuan , Li Chia-Jung , Chern Chyi-Uei , Chen Yu-Chen , Lin Li-Te , Tsui Kuan-Hao 
Published: January 2023

Abstract
Background
GnRH agonist (GnRHa) has been reported to have direct effects and functional roles in the endometrium and embryos. Several meta-analyses have shown that GnRHa administration in the luteal phase improved the live birth rate or pregnancy rate in both fresh and frozen embryo transfer (FET) cycles. The aim of this study was to investigate whether luteal GnRHa administration could also improve in vitro fertilization (IVF) outcomes in patients undergoing hormone replacement therapy (HRT) cycles with GnRHa suppression.
Methods
The retrospective cohort study included a total of 414 patients undergoing GnRHa-HRT FET cycles. The study group included 216 patients receiving an additional single dose of GnRHa in the luteal phase following embryo transfer. A total of 198 patients in the control group did not receive luteal GnRHa. The baseline and cycle characteristics and reproductive outcomes were compared between the two groups.
Results
Baseline and cycle characteristics were similar between the two groups, except lower AMH levels were found in the luteal GnRHa group than in the control group. The luteal GnRHa group had a significantly higher ongoing pregnancy rate and live birth rate than the control group. The multivariate analysis revealed that luteal GnRHa administration was positively associated with ongoing pregnancy (OR 1.66, 95% CI 1.01–2.72, P = 0.048) and live birth (OR 1.67, 95% CI 1.01–2.75, P = 0.044). When the subgroup of patients with recurrent implantation failure (RIF) was analyzed, the multivariate analysis also showed that luteal GnRHa administration had beneficial effects on ongoing pregnancy (OR 2.79, 95% CI 1.14–6.82, P = 0.024) and live birth (OR 2.89, 95% CI 1.15–7.22, P = 0.023).
Conclusions
Our data suggest that the addition of one luteal dose of GnRHa may improve the live birth rate in patients undergoing the GnRHa-HRT protocol, especially in RIF patients.
Fever and leukemoid reaction in bladder cancer: a case report and review of the literature
Authors: Huang Tianrun , Xu Jiguo , Lu Jingyuan , Alimu Parehe , Chen Chunlei , Chu Chenlong , Liu Jianhe 
Published: January 2023

Abstract
Background: to discuss the diagnosis, treatment and mechanism of leukemoid reaction in bladder cancer.
Methods: to present and analyze the clinical data of a patient who had urothelial carcinoma complicated with leukemoid reaction
Result: The patient had years of smoking history. He underwent six TURBT operations during the time of 31st Aug 2015 to 26th Oct 2022. Pathological diagnosis deteriorated from low-grade papillary urothelial carcinoma to high-grade. The patient did not keep to regular bladder perforation or routine follow-up cystoscopy. He also refused radical resection intervention. Last CT results show the following: multiple tumors in the bladder, bilateral ureter bladder entrance invasion, bilateral renal pelvis and ureter dilatation , multiple lymphadenopathy in the pelvis and along the right iliac artery. After cystoscopy examination and urethral catheter was placed, creatinine level gradually decreased. However, body temperature raised from 38 oC to 40o C. White blood cell count increased from 67.83*109/L (neutrophils being 64.5*109/L) to 72.17*109/L (neutrophils being 70.27*109/L). The patient was considered to have leukemoid reaction complicated with bladder cancer. The patient refused to have bone marrow biopsy, palliative care was provided instead. The patient passed away on 28th Oct 2022.
Conclusion: Bladder cancer patients complicated with leukemoid reactions are rarely reported clinically. Even after surgical resection, the outcome was poor. Monitoring of G-CSF level in blood can help to make predictions of the patient’s health condition. Blocking the G-CSF signaling pathway might work as a future therapeutic target for bladder cancer complicated with leukemia reaction.
The Application of Biomaterials in Ecological Remediation of Land Pollution: Bioremediation of Heavy Metals in Cement Contaminated Soil Using White-Rot Fungus Pleurotus sajor-caju
Authors: Bukola Raheem Waliyyat , Omowunmi Fadina Olubunmi , Omowumi Idowu Olufunmilayo , Olalekan Raimi Morufu , Iyingiala Austin-Asomeji 
Published: January 2023

Abstract

Environmental pollution is a result of cement manufacture. Soil and plant analysis at the Lafarge Cement Factory (LCF) as well as bioremediation of soils contaminated with cement at various concentrations were done. Human-induced heavy metal mobilization in the biosphere has developed into a significant phenomenon. This study used atomic absorption spectrophotometry to determine the levels of Ni, Cr, Pb, and Zn in 15 soil samples and 36 Synedrella nodiflora plants that were taken from the area around the Lafarge Cement factory in Sagamu, Nigeria (AAS). The findings of the metal study showed that some metals exceeded the essential limitations for the soil and plants, as well as the natural background levels. The white-rot fungus Pleurotus sajor-caju was investigated for its ability to mineralize heavy metals. Five kilograms of soil was carefully weighed and thoroughly mixed with cement to give 0.1%, 0.2%, 0.3% and 0.4% contamination levels, five kilograms of the contaminated soil from the vicinity of the cement factory with an unknown percentage level of contamination was also weighed and a set control was also weighed (0%). Following the addition of the fungus to the soil samples using rice straw as a substrate, the samples were incubated for a month. After a month of the fungus' incubation, the soil's heavy metal level significantly decreased. After a month, P. sajor-caju was able to mineralize the heavy metals and improve the soil's nutrients. In order to initiate the ecological restoration process for soil contaminated by cement, P. sajor-caju can be used as a bioremediation agent.
The Nitric Oxide Problem: Can Proton Pump Inhibitors Delay Fistula Maturation?
Authors: DISKIN CHARLES J. , Dansby Linda , Thomas Carter , Radcliff Lautrec , Diskin Charles Dyer 
Published: January 2023

Abstract
INTRODUCTION: We have previously shown that the position and presence of a hemodialysis catheter will delay maturation of the first fistula created for hemodialysis patients. Since that publication it has been suggested that the use of a proton pump inhibiter will adversely affect endothelial function. We therefore re-examined our data base to determine of the adverse effect of proton pump inhibiters on the endothelial would also delay fistula maturation.
METHODS: This was the re-examination of a database from a prospective observational study of 808 patients who underwent the creation of an autologous arteriovenous fistula for their first hemodialysis access who were evaluated for the length of use of a temporary catheter. The variables studied for their effect upon catheter use included: location in the forearm or upper arm, age, the presence of diabetes, vascular disease or smoking history. To those variables we added the use of a proton pump inhibiter.
FINDINGS: For upper arm fistulas, the use of a proton pump inhibiter appeared to delay upper arm fistula maturation (p=0.01) but not forearm maturation when in the presence of a long-term dialysis catheter (p=0.44).
DISCUSSION: Proton pump inhibiter use may adversely affect or delay fistula maturation, but further study is needed.
iPACK block vs. periarticular injection for total knee arthroplasty. A comprehensive review
Authors: Domagalska Małgorzata , Wieczorowska-Tobis Katarzyna , Geisler-Wojciechowska Alicja , Grochowicka Monika , Kowalski Grzegorz 
Published: January 2023

Abstract
Introduction
Total knee arthroplasty (TKA) is commonly performed in patients with end-stage osteoarthritis or rheumatoid arthritis of the knee to reduce joint pain, increase mobility and improve quality of life. However, TKA is associated with moderate to severe postoperative pain, which remains a significant clinical challenge. Surgeon-administered PAI and anesthesiologist-administered iPACK have proven viable alternatives to conventional peripheral nerve blocks. This review aims to discuss which IPACK block or periarticular injection, combined or not with different peripheral nerve blocks, has better effects on postoperative rehabilitation, patient satisfaction, and overall outcome.
Material and Method
The literature was reviewed through four electronic databases: PubMed, Cochrane Library, Google Scholar, and Embase.
Results
The initial search yielded 494 articles. Fifty-eight relevant articles were selected based on relevance, recentness, search quality, and citations. Six studies compared PAI to peripheral nerve block (PNB), and eight studies checked the effectiveness of adding PNB to
PAI. Three studies compared iPACK to PNB, and ten studies checked the effectiveness of adding PNB to iPACK.
Conclusions
The best analgesic effect is obtained by combining PAI or iPACK with a peripheral nerve block, particularly with ACB, due to its analgesic and motor-sparing effect, and satisfactory analgesia
Mathematical Model of Oxygen Transport in Tuberculosis Granulomas II: Transvascular and Interstitial Convection, Diffusion, and Reaction
Authors: Datta Meenal , Kennedy McCarthy , Via Laura E. , Baish James W. , Xu Lei , Dartois Veronique ,   Clifton E. Barry, 3rd, Jain Rakesh K. 
Published: January 2023

Abstract

Physiological abnormalities in pulmonary granulomas – pathological hallmarks of tuberculosis (TB) – compromise the transport of oxygen, nutrients, and drugs. In prior studies, we demonstrated mathematically and experimentally that hypoxia and necrosis emerge in the granuloma microenvironment (GME) as a direct result of limited oxygen availability. Building on our initial model of avascular oxygen diffusion, here we explore additional aspects of oxygen transport, including the roles of granuloma vasculature, transcapillary transport, plasma dilution, and interstitial convection, followed by cellular metabolism. Approximate analytical solutions are provided for oxygen and glucose concentration, interstitial fluid velocity, interstitial fluid pressure, and the thickness of the convective zone. These predictions are in agreement with prior experimental results from rabbit TB granulomas and from rat carcinoma models, which share similar transport limitations. Additional drug delivery predictions for anti-TB-agents (rifampicin and clofazimine) strikingly match recent spatially-resolved experimental results from a mouse model of TB. Finally, an approach to improve molecular transport in granulomas by modulating interstitial hydraulic conductivity is tested in silico.
Experiência da Educação Permanente em Saúde em um Centro de Atenção Psicossocial II na Amazônia
Authors: Messias Ana Cristina Sales de , Souza Ândrea Cardoso de , Almeida Ana Clementina Vieira de 
Published: January 2023

Este estudo traz como tema a Educação Permanente em Saúde – EPS, a partir de uma necessidade de realizar uma análise crítica dos processos de EPS no Centro de Atenção Psicossocial II na Amazônia. Como as ações de EPS implantadas no CAPS Náuas influenciaram nos processos de trabalhos da equipe para o desenvolvimento de uma Atenção Psicossocial - AP? Compreender como as ações de EPS influenciaram nos processos de trabalho da equipe para o desenvolvimento de uma AP e narrar a experiência de EPS do CAPS Náuas de maio 2014 a maio de 2022 identificar e analisar as estratégias de EPS; , na perspectiva dos profissionais, os aspectos positivos e/ou negativos experiência e como as ações de EPS contribuíram para a qualificação profissional; a melhoria da qualidade do cuidado aos usuários; o desenvolvimento do trabalho em equipe e nos processos de gestão da unidade, e; desenvolver propostas que subsidiem as práticas de um trabalho interprofissional e as estratégias de gestão do cotidiano da unidade. Uma abordagem qualitativa, na modalidade pesquisa intervenção, na perspectiva da narrativa, com referencial teórico os conceitos de AP e EPS. Os dados serão agrupados e analisados com referência na análise temática e serão formuladas categorias analíticas. A amostra será a totalidade dos profissionais do CAPS Náuas, sem distinção de nível de formação ou de categoria profissional. Como produto, pretende-se desenvolver ações de EPS com a rede intra e intersetorial para potencializar a AP na Regional de Saúde do Vale do Juruá, Tarauacá/Envira.
Palavras-Chave: Educação Continuada; Reabilitação Psiquiátrica; Equipe de Assistência ao Paciente; Saúde Mental; Serviços de Saúde Mental.
Hotelaria hospitalar e o idoso hospitalizado: considerações sobre rouparia na prática clínica em enfermagem
Authors: Marins Aline Miranda da Fonseca , Pinto Cecília Maria Izidoro , Santos Anne Caroline Rodrigues dos , Ferreira Priscila Brigolini Porfírio , Oliveira Francimar Tinoco de , Correa Amanda da Silva 
Published: January 2023

Com o envelhecimento populacional observa-se o aumento do número de pessoas idosas que são hospitalizadas. O hospital precisa ser visto como um prestador de serviços de qualidade, proporcionando conforto, bem-estar e alívio, elementos essenciais do serviço de governança hospitalar. Buscou-se identificar, a partir de revisão integrativa na literatura em saúde, estudos que tratam da rouparia hospitalar, com vistas ao cuidado de enfermagem ao idoso hospitalizado na prática clínica. Revisão integrativa realizada no período de maio a agosto de 2022. As bases selecionadas foram a Biblioteca Virtual em Saúde (BVS), especificamente o Portal Regional da BVS - Informação e Conhecimento para a Saúde (https://bvsalud.org/) e a ferramenta de busca Google Acadêmico (https://scholar.google.com.br/?hl=pt). Após o levantamento do material, nove estudos compuseram a amostra final para leitura na íntegra e análise de seu conteúdo. Eles apontaram que a saúde do idoso, no contexto hospitalar, deve estar alicerçada no conforto e no bem-estar. É necessário que haja uma conexão entre a hotelaria hospitalar, no eixo serviço de governança / rouparia, com a saúde do idoso e com o cuidado especializado de enfermagem a essa clientela, para propiciar e/ou provocar uma reorganização das atividades hospitalares com oferta de qualidade, conforto e segurança. Por fim, a rouparia deve ser vista não só como um dos elementos de apoio, mas também, como um elemento integrador e sustentador das necessidades prioritárias do idoso hospitalizado.
Palavras-Chave: Serviço Hospitalar de Lavanderia; Serviço Hospitalar de Enfermagem; Idoso; Hotelaria Hospitalar.
religiosidade nas universidades de odontologia do Brasil
Authors: Souza Ianderlei Andrade , Santos Maria da Conceição Quirino dos , Tavares Marilei de Melo , Gomes Antônio Marcos Tosoli , Yarid Sérgio Donha 
Published: January 2023

Objetivo: Conhecer a religiosidade de docentes e discentes dos cursos de odontologia de diferentes Instituições de Ensino Superior no Brasil. Métodos: trata-se de um estudo transversal realizando com 390 discentes e docentes de diferentes cursos de odontologia do Brasil. Utilizou-se a escala DUREL para mensuração do envolvimento religioso. Resultados: foi evidenciada diferença estatisticamente significante da média dos domínios “Religiosidade Organizacional”, “Religiosidade Não Organizacional” e “Religiosidade Intrínseca” para as variáveis sexo (sendo maiores no feminino), e região (sendo maiores na região nordeste). No que concerne a dedicação às atividades religiosas, 45,4% o fazem diariamente e 74,4% afirmaram sentir a presença de Deus em suas vidas. Quanto a transcendência da religião para os as atividades da vida diária 42,1% afirmaram ser totalmente verdade que a religião esteja por traz de todo o seu modo de viver e que em geral é verdade que a religião está em todos os aspectos da vida (33,8%). Conclusão: O estudo evidenciou as maiores médias dos domínios do DUREL (RO, RNO, RI) para o sexo feminino e para participantes das regiões norte e nordeste, em consonância com o apontado na literatura, destacando que os aspectos da religiosidade são influenciados por questões individuais, assim como situacionais relacionados a fatores sociais.
Palavras-Chaves: Religião e Ciência; Universidades; Odontologia; Docentes de Odontologia; Estudantes de Odontologia.
A Comprehensive Review on the Role of Polymers in Ocular Drug
Delivery
Authors: Paramjot  , Wadhwa Sheetu , Sharma Arun , Singh Sachin Kumar , Vishwas Sukriti , Kumar Rajesh , Singh Saurabh , Dua Kamal , Chellappan Dinesh Kumar , Gupta Gaurav 
Published: January 2023

Abstract:
Amongst different routes of drug delivery systems, ophthalmic drug delivery still requires a
careful investigation and strict parameter measurements because the eyes are one of the most sensitive
parts of the body and require special attention. The conventional systems for eyes lead to rapid elimination
of formulation and hence very small contact time on the ocular epithelium. The current review article
covers various types of polymers used in ocular drug delivery along with their applications/
limitations. Polymers are widely used by researchers in prodrug techniques and as a penetration
enhancer in ocular delivery. This article covers the role and use of different polymeric systems which
makes the final formulation a promising candidate for ophthalmic drug delivery.

:
The researchers are still facing multiple challenges in order to maintain the therapeutic concentration of
the drug in the eyes because of its complex structure. There are several barriers that further restrict the
intraocular entry of the drug. In order to remove/reduce such challenges, these days various types of
polymers are used for ocular delivery in order to develop different drug carrier systems for better efficacy
and stability. The polymers used are highly helpful in increasing residence time by increasing the
viscosity at the ocular epithelium layer. Such preparations also get easily permeated in ocular cells. The
combination of different polymeric properties makes the final formulation stable with prolonged retention,
high viscosity, high permeability, and better bioavailability, making the final formulation a promising
candidate for ocular drug delivery.
Synthesis by Microwave Irradiation, Molecular Structural Analysis and
Trypanocidal Activity of Novel Pyrazole-tetrahydropyrimidine Derivatives
Authors: Pereira Cynthia Nathalia , de Oliveira Júlia Akihoshi , da Silva Lara Leonardo , Rocha Orlando Lorraine Martins , de Souza Pereira Mirian Claudia , dos Santos Maurício Silva 
Published: January 2023

Background:
A series of new eight 2-(1-aryl-3-methyl-1H-pyrazol-4-yl)-1,4,5,6-tetrahydropyrimidines
1(a-h) were synthesized by microwave irradiation technique. In vitro phenotypic
screening was performed to evaluate the effect of these compounds on intracellular amastigotes
forms of Trypanosoma cruzi, the etiological agent of Chagas disease.

Methods:
Compounds 1(a-h) were synthesized from pyrazole-carbonitriles 2(a-h) employing microwave
irradiation (50W) for 10-20 minutes. Physicochemical properties were calculated using
OSIRIS DataWarrior. The toxic effect on mammalian cells (Vero Cells) and the trypanocidal activity
against Trypanosoma cruzi (Dm28c-Luc) were also evaluated.

Results:
Compounds 1(a-h) were obtained in 24-94% yields. They were completely characterized
by Fourier Transform Infrared (FT-IR), Nuclear Magnetic Resonance (NMR) and High-Resolution
Mass Spectrometry (HRMS) analyses. The derivatives showed low trypanocidal activity, with IC50
ranging from 47.16 to > 100 μM, with lower activity than benznidazole (1.93 μM) used as reference
drug.

Conclusion:
The attractive features of this synthetic methodology are mild conditions, short reaction
time, and low power. All derivatives showed low toxicity in mammalian cells, good oral bioavailability,
and did not violate Lipinski´s rule of 5.
Based on the Network Pharmacology to Analyze the Effect of Chuanxiong in Improving Diabetic Nephropathy
Authors: Li ChangYan , Su Feng , Zhang Le , Liu Fang , Li Zhen , Fan Wen Xing , Yang Jing , Mali Niroj 
Published: January 2023

Aim:
Chuanxiong diabetic nephropathy, network pharmacology, molecular docking, NCOA1, NCOA2, diabetic
nephropathy (DN), ACEI/ARB.

Background:
The development of network pharmacology promotes the process of medicinal transformation
of traditional Chinese medicine. This study took Chuanxiong as an example to analyze the active
components in the treatment of DN.

Objective:
Molecular docking and other technologies have effectively helped the complex find the disease's
active ingredients.

Methods:
The data of Chuanxiong was collected from the TCPSP database, DN gene expression data
were collected through the NCBI database, and DN-related genes were obtained through differential analysis.
In addition, the regulatory network of Chuanxiong and the main active components of DN treatment
was constructed using String and Cytoscape tools. At the same time, PPI network interaction analysis was
performed on core genes and GO. KEGG analysis was performed to predict essential genes using the
Auto Dock tool.

Results:
Eight active components of Chuanxiong were screened out. NCOA1 and NCOA2 could interact
with Angelica lactone A, Myricetin, Chrysophanol, Chuanxiong, naphthalize, and Chrysophanol. Meanwhile,
Angelica Lactone A, Myricetin, Chrysophanol, Chuanxiong, naphthafunolide, and Chrysophanol
can affect the regulation of estrogen signaling pathway, endocrine and other factors regulating calcium
reabsorption and adipogenesis of adipocytes through the regulation of steroid hormone stimulation and
regulation of cAMP-dependent protein kinase complex.

Conclusion:
NCOA1 and NCOA2 can be used as pharmacodynamic targets of Chuanxiong for improving
DN.