bluuebunny/crossref_metadata_2025_split huggingface dataset:
Biomechanical testing, finite element analysis and prospective, randomized, clinical study of single screw chephalomedullary nailing vs integrated dual interlocking screw fixation for unstable (31A21-3) intertrochanteric fractures in patients &gt; 70 years old.
Authors: Panagopoulos Andreas , Argyropoulou Evangelia , Kokkalis Zinon T , Parchas Nikolaos , Tserpes Konstantinos 
Published: May 2023

Abstract
Background: Hip fractures are an increasingly common consequence of falls in older people that are associated with a high risk of death and reduced function. The vast majority of intertrochanteric fractures require surgical treatment to withstand early mobilization and weight bearing, which prevents complications due to prolonged bed rest and aids in fracture healing.
Methods: This study is compromised by two parts, the experimental study and the clinical part. In the first part, a standard 130ο degrees nail will be used with the appropriate lag screw(s) and dynamic distal locking in synthetic osteoporotic femurs and the transmission of forces in the proximal femur, measured by a cortical surface-strain distribution, will be evaluated using digital image correlation (DIC). Finite element parametric models of the bone, the nails and their interface will be also developed. Finite element computations of surface strains in implanted femurs, after being validated against biomechanical testing measurements, will be used to assist the comparison of the nails by deriving important data on the developed stress and strain fields, which cannot be measured through biomechanical testing. In the other part, will set up a prospective, randomized, comparative clinical study among the Gamma3 and IT chephalomedullary nailing, in order to investigate if there are any statistical important differences in the main radiological measurements and functional status in closed unstable intertrochanteric fractures (A21-3) in patients aged over 70 years-old at the 24 weeks follow-up evaluation using patient reported disease specific outcomes.
Discussion: This study will be the first to compare clinical, radiological and biomechanical measurements off the two different chephalomedullary nails. Our main hypothesis is that the IT nail would provide better radiological outcome and probably better clinical results than the Gama3 nail.
Clinical Trial registration: International Standard Randomized Controlled Trial Number (ISRCTN): https://doi.org/10.1186/ISRCTN15588442, registered on 19/4/2022
Efficacy of in situ regenerative therapy in refractory orthopedic wounds in children
Authors: Chen Xiang , Fang Yu , Jiang Linjun , Chen Lian , Zheng Chao 
Published: May 2023

Abstract
Objective To evaluate the efficacy of in situ regenerative therapy in refractory orthopedic wounds in children.Methods Sixty children with refractory wounds admitted to our department from January 2020 to July 2021 were recruited and randomly assigned to receive in situ regenerative therapy (observation group) and vacuum sealing drainage (VSD) (control group). Outcome measures included postoperative recovery, cytokine levels, visual analogue scale (VAS), and complications.Results In situ regenerative therapy achieved significantly faster growth of fibrous connective tissue, shortened time of wound healing, as well as a higher rate of flap formation as compared with VSD (P < 0.05). The levels of IL-6/8 in wound tissues treated by in situ regenerative therapy were lower than those by VSD (P < 0.05). 83.3% of refractory wounds were treated efficiently by in situ regenerative therapy as compared with VSD(66.7%). Lower pain scores and secretion scores achieved by in situ regenerative therapy(P < 0.05).Conclusion In situ regenerative therapy is an effective technology for treating pediatric refractory orthopedic wounds, which promotes the growth of fibrous connective tissue, shortens the healing time, as well as reduces the inflammatory response of local tissues.
Robot-assisted thoracoscopic esophagectomy versus thoracoscopic esophagectomy
Authors: Xue Mengchao , Liu Junjie , Lu Ming , Zhang Huiying , Liu Wen , Tian Hui 
Published: May 2023

Abstract
Background
The gold standard for treating resectable esophageal cancer is esophagectomy. Robot-assisted thoracoscopic esophagectomy (RATE) is a technique that bridges the gap between open esophagectomy and minimally invasive surgery, although there is little evidence to support its superiority over traditional thoracoscopic esophagectomy (TE) in treating thoracic esophageal cancer.
Method
We included 159 patients who received TE and 35 patients who had RATE in this research after retrospectively analyzing clinical data from patients with esophageal cancer who underwent surgery at Qilu Hospital between August 2020 and August 2022. Both groups' intraoperative, postoperative, and preoperative patient characteristics were assessed.
Results
With regard to preoperative patient characteristics, all P values were greater than 0.05 in the TE and RATE groups except for height, and the preoperative characteristics of the two groups could be considered similar. In terms of intraoperative indices, there were no significant differences between the two groups in terms of TNM stage of resected tumor, tumor tissue type and ASA score. However, there were statistically significant differences between the TE and RATE groups in terms of operative time, intraoperative bleeding, total number of lymph nodes resected, and number of lymph nodes resected in the thoracoabdominal cavity. Regarding postoperative characteristics, there were statistically significant differences in pain scores on the first postoperative day and chest drainage on the first postoperative day, and there were no significant differences in the remaining characteristics between the two data groups.
Conclusion
This study confirmed the feasibility and safety of RATE for esophageal cancer by comparing it with TE. We concluded that RATE does result in more complete lymph node clearance, reduced operative time and surgical bleeding, and postoperative relief of patient pain and chest drainage. We plan to conduct the next clinical study with long-term follow-up to evaluate the tumor clearance, recurrence and survival rates after receiving RATE for esophageal cancer to investigate the role of RATE in esophageal cancer.
Association between intrapleural urokinase monotherapy and treatment failure in patients with pleural infection: a retrospective cohort study
Authors: Taniguchi Jumpei , Matsui Hiroki , Nagai Tatsuya , Otsuki Ayumu , Ito Hiroyuki , Sugimura Hiroshi , Nakashima Kei 
Published: May 2023

Abstract
Background
Pleural infection, an infection of the pleural space, is frequently treated with antibiotics and thoracic tube drainage. In case of insufficient drainage, an intrapleural fibrinolytic agent is considered before surgical intervention. However, the effectiveness of fibrinolytic monotherapy is still controversial. Therefore, we aimed to examine the association between urokinase monotherapy and treatment failure in patients with pleural infection.
Methods
In this retrospective observational study, patients with pleural infection underwent chest tube insertion were divided into two groups including patients treated with or without intrapleural instillation of urokinase. The propensity score overlap weighting was used to balance the baseline characteristics between the groups. Treatment failure was defined by the composite primary outcome of in-hospital death and referral for surgery.
Results
Among the 94 patients, 67 and 27 patients were in the urokinase and non-urokinase groups, respectively. Urokinase monotherapy improved the composite outcome between the groups (19.4% vs. 48.1%, p = 0.01). After adjusting using propensity score overlap weighting, urokinase monotherapy improved the composite outcome compared to the non-urokinase group (19.0% vs. 59.5%, p = 0.003).
Conclusions
Urokinase monotherapy can be an important nonsurgical treatment option for patients with pleural infection.
Trial registration:
The participants were retrospectively registered.
Exploring Hazard of Social Media Use on Adolescent Mental Health
Authors: HALIM MOHD RADZI TARMIZI A , IBRAHIM MUHAMAD ARIFF , Adib Nik Adlin Nazrin Nik Mohd , Hashim Huzaini , Omar Rosmaria 
Published: May 2023

Abstract
Background
Previous studies have cautioned about the negative impact of social media use on the mental health of adolescents and emerging adults. In 2021, the National Institutes of Health Malaysia emphasized the urgent need to address digital-related mental health issues, which pose a significant gap in our understanding. Nevertheless, there has been a lack of research on the effects of social media addiction on the mental well-being of local adolescents. This study aims to examine the effect of social media use on mental health issues among adolescents in Kelantan, Malaysia.
Methods
A total of 384 respondents voluntarily participated in this cross-sectional study involving ten districts in Kelantan using the snowball sampling method.
Results
Analysed data finds social media addiction correlates significantly with depression, suicide ideation and self-esteem. Multiple regression analysis indicated that suicide ideation was predicted by social media addiction and depression but not self-esteem. Furthermore, social media moderates the relationship between depression and suicidal ideation.
Conclusion
Controlling social media use may prevent addiction and promote greater mental health among adolescents.
On statistical convergence of set sequences in fuzzy anti-normed linear space
Authors: Pandit Shailendra 
Published: May 2023

Abstract
In this article, we have studied the fuzzy α-anti Wijsman convergence, fuzzy α-anti Wijsman statistical convergence, and fuzzy α-anti Hausdorrf statistical convergence where 0 < α < 1, of set sequences of non-empty closed sets in fuzzy anti-normed linear spaces (M, ψ, ⋄) with regard to the fuzzy anti norm(FAN) ψ. Furthermore, certain important theorems and examples based on the notion were presented.
2020 MSC: 40A05, 46S40
Synthesis and Catalytic Activity of CoMo and CoMoW Catalysts supported on γ-Al 2 O 3 for Efficient Naphtha Hydrodesulfurization
Authors: Albdiry Mushtaq , Mahdi Fouad 
Published: May 2023

Abstract
Bimetallic Co5Mo15 of 5 wt.% Cobalt as a promoter and 15 wt.% Molybdenum as an active metal and trimetallic Co5Mo15-xWx (x = 1, 3, 5 wt.%) heterogeneous catalysts supported on gamma alumina (γ-Al2O3) were synthesized by an incipient wetness co-impregnation process. The structural and the physicochemical characteristics of the prepared bi- and tri-metallic catalysts were evaluated by the XRD, SEM, BET and BJH, respectively. The role of third W active metal on the catalytic activity was determined through a hydrodesulfurization (HDS) reaction of naphtha at four different reaction temperatures (250, 275, 300, 325ºC) and four liquid hourly space velocities, LHSV (3, 4, 5, 6 hr-1) under constant 1.5 MPa H2 pressure. The trimetallic CoMoW5 catalyst exhibited the maximal HDS efficiency at 325ºC and 3 hr-1 liquid flow of 88% sulfur removed compared to the CoMo catalyst. This was ascribed for the role of the highly dispersed active W metal and presence of the sulfided CoMoWS and CoWS sites on the alumina surface that leads to increase the surface area and the porous structure, and enhancing the metal/sulfur bond.
Intraperitoneal injection of mesenchymal stem cells-conditioned media (MSCS-CM) treated monocyte can potentially alleviate motor defects in experimental autoimmune encephalomyelitis female mice; an original experimental study
Authors: Kondori Bahman Jalali , Abdolmaleki Amir , Raei Mahdi , Ghaleh Hadi Esmaeili Gouvarchin 
Published: May 2023

Abstract

Introduction: Multiple sclerosis (MS) is destructive pathology of myelin in central nervous system (CNS) leading to occurrence of physical complications. Experimental autoimmune encephalomyelitis (EAE) is the laboratory model of MS widely used for CNS-associated inflammatory research. Cell therapy using macrophage M2 (MPM2), as a cell type with anti-inflammatory feature, seems useful for EAE treatment. This study was aimed to investigate the therapeutic anti-inflammatory effects of intraperitoneal (IP) injection of MPM2 cells on alleviation of motor defect in female EAE-affected mice.
Materials and Methods: 24 C57/BL6 female mice were divided into EAE (EAE-affected mice), EAE+Dexa (EAE-affected mice receiving dexamethasone), EAE+PBS (EAE-affected mice receiving PBS) and EAE+MP2 (EAE-affected mice receiving MPM2). EAE was induced through application of spinal homogenate of guinea pigs. MPM2 cells were extracted and cultured from bone marrow and injected (106cells/ml) in three days of 10, 13 and 16 post-immunization (p.i). The clinical score (CS), anti-inflammatory cytokines, pro-inflammatory gene expression and histopathological investigations were considered. Data were assessed analyzed using SPSS software (v.19) and p<0.05 was assumed significant level.
Results: IP injection of MPM2 in EAE-affected mice can significantly (p<0.05) alleviate CS index, accelerate anti-inflammatory cytokines (IL-4, IL-10), and attenuate pro-inflammatory genes expression (TNF-α, IL-1β). These findings were also approved by histopathological tissue staining.
Conclusion: IP injection of MPM2 to the EAE-affected mice can potentially reduce the CNS inflammation, neuronal death and myelin destruction leading to the improvement of animal movement behaviors.
A new result on the long lived sunspot magnetic flux and their association with CME speed
Authors: Ibrahim M. Syed , Ebenezer E. , Raj S. Aswin Amirtha , Shanmugaraju A. 
Published: May 2023

Abstract
In this article, we calculate sunspot magnetic flux and look for a connection with Coronal Mass Ejection (CME) speeds. The solar activity peaked between 2011 and 2016 in Solar Cycle 24, and we gathered long-term sunspot data from the northern and southern hemispheres during this period. Long-lived sunspots will undoubtedly be associated with flare-CME eruptions. Finding the relationship between the CME speed and the sunspot’s area and magnetic field is crucial to forecast CME speed in th near-Sun environment. We used solar charts from Kodaikanal solar observatory (KSO) and the square grid method to determine the sunspot’s area. We calculated the Line of Sight (LOS) magnetic field for every long-lived sunspot using magnetogram images from SDO/HMI for various locations for all the available observation days at KSO. According to this analysis, the sunspot area and flux are found to significantly impact the fast CMEs with speed ≥1000 km s −1. In the present study concerning the classification of sunspot types, we identified that βγ has long lived group of sunspots compared to other groups. The values of logarithmic magnetic flux (sunspot area x magnetic field) can be related with CME speeds as V CME = 754.29 x log(magnetic flux)-2888. The most important factor in determining the CME speeds is the values of the logarithmic magnetic flux. At smaller logarithmic magnetic flux values (≤5 MHS G) and faster CMEs (≥1000 km s −1), the magnetic flux has a better correlation with the CME speed.
Preliminary Exploration of Structure–Function Crosstalk in Colorectal Cancer Research: Protein Structuromics
Authors: Xiao Nan , Zhang Jing , Xu Guangshuai , Pan Xin , Yang Guang , Yang Jinhua , Li Chi , Liu Kang , Li Yingxin , Chen Zhibo , Yin Chaoqun , Li Xingqi , Wang Zhina 
Published: May 2023

Abstract
Colorectal cancer (CRC) refers to cancer that develops from the colon or rectum (parts of the large intestine). Signs and symptoms include blood in the stool, changes in bowel movements, weight loss, and fatigue. Since 1923, when the disease was first named, survival rates have always been unsatisfactory. Despite great advances in molecular biology and traditional treatment methods, many questions remain to be answered regarding cancer occurrenceand the underlyingmechanism. Medical doctors remain stymied regarding tumor recurrence and worsening disease after effective treatment. To better understand the relevant questions, in this study, 20 oncogenes and 20 anti-oncogenes were examined in relation to protein structure, from protein structure analysis and dynamic analysis methods to 3D structure analysis and systematic analysis of the structure‒function relationships of proteins. We hope that these analyses will help promote mechanistic research and the development of new treatments for CRC.
Women in Sport Leadership, Fifty Years Since Title IX
Authors: Brawner Candace 
Published: May 2023

Women in athletic administration in secondary public schools in Texas remain a significant minority to their male counterparts despite nearly fifty years since the passage of Title IX. This qualitative research study used narrative inquiry to investigate the factors leading to success among female athletic administrators in secondary education Creswell’s (2013) method for coding information and identifying themes. The study results are organized by the four research questions. The findings include the importance and value of professional organizations for the personal development and networking opportunities for women. Work-life balance was noted among all the participants and the executive directors of the professional organizations as the largest factor for women leaving the industry. Desirable feminine traits, experience and connections, and influential male mentors and advocates were cited by the research participants as key factors to their personal advancement. Recommendations for practical application include partnerships between professional organizations and school districts to review key concerns as they relate to the recruit and advancement of women in athletic administration. This study provides suggestions for advancing women in athletic administration in Texas school districts including: removal of barriers, opportunity for training, district environment of readiness, professional organization support, and prioritization of work-life balance and family needs.
Comparative study of the effectiveness of phlebotonic drugs in the experiment
Authors: Pozdnyakov D. I. , Kozlova V. V. , Karmanovich A. A. , Rybalko I. E. 
Published: May 2023

Introduction. Chronic venous diseases are a common group of diseases with a significant risk of complications requiring timely correction. As a rule, phlebotonic drugs based on flavonoid complexes are used for the treatment and prevention of venous diseases.Aim. To evaluate the effectiveness of the use of various phlebotonic drugs in the conditions of experimental chronic venous insufficiency.Materials and methods. Varicose veins were modeled in Wistar rats by partial stricture of the deep femoral vein. The studied medicines were administered orally in a course of 30 days from the moment of surgery. During the work, the change in the following parameters was evaluated: the rate oflocal blood flow in the skin in dynamics, the degree of vascular permeability, the concentration of proinflammatory cytokines (TNF-α, IL-6) and matrix metalloproteinase 9 (MMP9) in the vascular wall. The rate of local blood flow was assessed by ultrasound Dopplerography. The change of vascular permeability was studied by the degree of extravasation of the Evans blue dye in the Miles test. The content of proinflammatory cytokines and MMR9 was determined by enzyme-linked immunoassay. The results were statistically processed.Results. The study showed that the course oral administration of all the studied venotonizing drugs led to the restoration of hemodynamics and a significant (p˂ 0.05) decrease in the degree of vascular permeability in relation to untreated animals. It is worth noting that the use of a micronised purified flavonoid fraction 1 contributed to the development of a more pronounced vasal effect, which was reflected in an increase in blood flow velocity and a decrease in vascular permeability compared to the rest of the studied drugs. At the same time, the administration of micronised purified flavonoid fraction 1 to animals led to a statistically significant decrease in the concentration of proinflammatory cytokines, which was not observed when using other drugs.Conclusion. The course administration of the micronised purified flavonoid fraction 1leads to the development of a pronounced phlebotonic effect, expressed in the restoration of microcirculation, a decrease of the inflammation in the vascular wall.
Performance evaluation of artificial neural network model in hybrids with various preprocessors for river streamflow forecasting
Authors: Momeneh Sadegh , Nourani Vahid 
Published: May 2023

Abstract

Accurate forecasting of hydrological processes and sustainable management of water resources is inevitable, especially for flood control and water resource shortage crisis in low-water areas with an arid and semi-arid climate, which is a limitation for residents and various structures. The present study uses different data preprocessing techniques to deal with complex data and extract hidden features from the stream time series. In the next step, the decomposed time series were used, as input data, to the artificial neural network (ANN) model for streamflow modeling and forecasting. The preprocessors employed included discrete wavelet transform (DWT), empirical mode decomposition (EMD), complete ensemble empirical mode decomposition with adaptive noise (CEEMDAN), successive variational mode decomposition (SVMD), and multi-filter of the smoothing (MFS). These preprocessors were used in hybrid with the ANN model to forecast the daily streamflow. In general, the results showed that the optimal performance of hybrid models has two basic steps. The first step is choosing a suitable approach to utilizing the input data to the model. The second step is to use the appropriate preprocessor. Overall, the results show that the MFS-ANN model in short-term forecasting and the SVMD-ANN model in long-term forecasting performed better than other hybrid models.
Territórios, redes e cidades
Authors: Souto Maior Fontes Breno Augusto , Furini Luciano Antonio 
Published: May 2023

Há alguns anos, um renomado cientista social publicou um livro intitulado “Cidades: a urbanização da humanidade”, indicando que, com a revolução industrial, o fenômeno urbano agora significa não uma formação espacial diversa, a cidade e seu hinterland, estruturando-se consoante os múltiplos arranjos territoriais isolados. O urbano desta vez se organiza em campos reticulares complexos e articulados, espalhando-se por espaços podem até ultrapassar as fronteiras político-administrativas dos Estados nacionais. As redes territoriais que estruturam as cidades sobrepõem-se aos arranjos tradicionais das cidades, entrincheiradas em suas peculiaridades espaço-temporais.
As dinâmicas entre redes territórios e cidades guardam, por um lado, uma série de divisões (da produção, do trabalho, da distribuição, do consumo, entre outras), que conferem sentido ao modo como a rede urbana é hierarquizada segundo os papéis das cidades. Por outro lado, expressa inúmeras formas de interações socioespaciais, articuladas por diferentes tipos de redes sociais, técnicas e urbanas, que permite identificar graus de heterarquia nas redes urbanas contemporâneas, relativizando a estrutura hierárquica anterior. Nesse sentido, é a lógica das redes que potencializa as novas formas de interações urbanas.