bluuebunny/crossref_metadata_2025_split huggingface dataset:
Seasonal variation in the incidence of primary intracerebral hemorrhage: a 16-year nationwide analysis
Authors: Baig Eman , Tannous Jonika , Potter Thomas , Pan Alan , Prince Taya , Britz Gavin , Vahidy Farhaan S. , Bako Abdulaziz T. 
Published: June 2023

IntroductionData on nationwide trends and seasonal variations in the incidence of Intracerebral Hemorrhage (ICH) in the United States (US) are lacking.MethodsWe used the Nationwide Inpatient Sample (2004–2019) and Census Bureau data to calculate the quarterly (Q1:January-March; Q2:April-June; Q3:July-September; Q4:October-December) incidence rates (IR) of adult (≥18 years) ICH hospitalizations, aggregated across Q1–Q4 and Q2–Q3. We report adjusted incidence rate ratios (aIRR) and 95% confidence intervals (CI) for differences in the quarterly incidence of ICH, as compared to acute ischemic stroke (AIS), between Q1Q4 and Q2Q3 using a multivariable Poisson regression model. We additionally performed stratified analyses across the four US regions.ResultsAmong 822,143 (49.0% female) ICH and 6,266,234 (51.9% female) AIS hospitalizations, the average quarterly crude IR of ICH was consistently higher in Q1Q4 compared to Q2Q3 (5.6 vs. 5.2 per 100,000) (aIRR, CI: 1.09, 1.08–1.11)—this pattern was similar across all four US regions. However, a similar variation pattern was not observed for AIS incidence. The incidence (aIRR, CI) of both ICH (1.01, 1.00–1.02) and AIS (1.03, 1.02–1.03) is rising.ConclusionUnlike AIS, ICH incidence is consistently higher in colder quarters, underscoring the need for evaluation and prevention of factors driving seasonal variations in ICH incidence.
Displaced center of pressure on the treated side in individuals with essential tremor after radiofrequency ablation: a longitudinal case–control study
Authors: Sato Atsuya , Taira Takaomi , Kitada Kazuya , Ando Toshiki , Hamaguchi Toyohiro , Konno Michiko , Kitabatake Yoshinori , Ishioka Toshiyuki 
Published: June 2023

BackgroundEssential tremor (ET) is a common involuntary movement disorder (IMD). Radiofrequency ablation (RFA) targeting the ventral intermediate nucleus (Vim) of the thalamus is a stereotactic neurosurgery performed in individuals with ET when pharmacotherapy is no longer effective. Though the reasons remain largely unclear, certain adverse events are known to appear post-RFA. These may be due to functional changes in the Vim, related to RFA-induced tremor reduction, or an adverse reaction to compensatory movement patterns used to perform movements in the presence of tremor symptoms.ObjectiveThis study aimed to understand the characteristics of post-RFA symptoms in individuals with ET.MethodsIn a longitudinal case–control study, we compared post-RFA symptoms between individuals with ET who underwent Vim-targeted RFA and those with IMD who underwent non-Vim-targeted RFA. Symptoms were compared preoperatively and 1-week and 1-month postoperatively. Quantitative assessments included center-of-pressure (COP) parameters, grip strength, Mini-Mental State Examination, two verbal fluency tests, and three types of physical performance assessments (upper extremity ability, balance ability, and gait ability).ResultsIndividuals with ET after RFA showed horizontal displacements of the COP to the treated side (the dominant side of the RFA target's hemisphere) at 1-week postoperatively compared to the preoperative period. The horizontal COP displacement was associated with balance dysfunction related to postural stability post-RFA. Other COP parameters did not significantly differ between the ET and IMD groups.ConclusionCOP displacement to the treated side may be due to a time lag in adjusting postural holding strategies to the long-standing lateral difference in tremor symptoms associated with tremor improvement after RFA.
Association of CSF and PET markers of neurodegeneration with electroclinical progression in Lafora disease
Authors: d'Orsi Giuseppe , Farolfi Andrea , Muccioli Lorenzo , Palumbo Orazio , Palumbo Pietro , Modoni Sergio , Allegri Vincenzo , Garibotto Valentina , Di Claudio Maria Teresa , Di Muro Ester , Benvenuto Mario , Bisulli Francesca , Carella Massimo 
Published: June 2023

PurposeTo evaluate the electro-clinical features in association with laboratory and instrumental correlates of neurodegeneration to detect the progression of Lafora disease (LD).MethodsWe investigated the electro-clinical longitudinal data and CSF Aβ42, p-tau181 and t-tauAg, amyloid, and 18F-FDG PET of five unrelated LD families.ResultsThree progressive electro-clinical stages were identified. The early phase was characterized by rare, generalized tonic-clonic and focal visual seizures, followed by the occurrence of myoclonus after a period ranging from 2 to 12 months. The intermediate stage, usually occurring 2 years after the onset of epilepsy, is characterized by a worsening of epilepsy and myoclonus associated with progressive dementia and cerebellar signs. Finally, the late stage, evolving after a mean period of 7 ± 1.41 years from the onset of the disease, was characterized by gait ataxia resulting in bedriddenness, severe dementia, daily/pluri-daily myoclonus, drug-resistant epilepsy, clusters of seizures or status epilepticus, and medical complications. Amyloid (CSF Aβ42, amyloid PET) and neurodegenerative (CSF p-tau181 and t-tauAg, FDG-PET) biomarkers indicate a pattern of cognitive impairment of the non-Alzheimer's disease type. A total of 80% of the LD patients showed more severe hypometabolism in the second FDG-PET scan compared to the first scan performed in a lower phase; the lateral temporal lobe and the thalamus hypometabolism were associated with the presence of intermediate or late phase.ConclusionsThree electroclinical and 18F-FDG PET evolutive stages are useful biomarkers for the progression of LD and could help to evaluate the efficacy of new disease-modifying treatments. The combination of traditional CSF biomarkers improves the diagnostic accuracy of cognitive decline in LD patients, indicating a cognitive impairment of the non-Alzheimer's disease type.
Binocular head-mounted chromatic pupillometry can detect structural and functional loss in glaucoma
Authors: Quan Yadan , Duan Huiyu , Zhan Zongyi , Shen Yuening , Lin Rui , Liu Tingting , Zhang Ting , Wu Jihong , Huang Jing , Zhai Guangtao , Song Xuefei , Zhou Yixiong , Sun Xinghuai 
Published: June 2023

AimThe aim of this study is to evaluate the utility of binocular chromatic pupillometry in detecting impaired pupillary light response (PLR) in patients with primary open-angle glaucoma (POAG) and to assess the feasibility of using binocular chromatic pupillometer in opportunistic POAG diagnosis in community-based or telemedicine-based services.MethodsIn this prospective, cross-sectional study, 74 patients with POAG and 23 healthy controls were enrolled. All participants underwent comprehensive ophthalmologic examinations including optical coherence tomography (OCT) and standard automated perimetry (SAP). The PLR tests included sequential tests of full-field chromatic stimuli weighted by rods, intrinsically photosensitive retinal ganglion cells (ipRGCs), and cones (Experiment 1), as well as alternating chromatic light flash-induced relative afferent pupillary defect (RAPD) test (Experiment 2). In Experiment 1, the constricting amplitude, velocity, and time to maximum constriction/dilation were calculated in three cell type-weighted responses, and the post-illumination response of ipRGC-weighted response was evaluated. In Experiment 2, infrared pupillary asymmetry (IPA) amplitude and anisocoria duration induced by intermittent blue or red light flashes were calculated.ResultsIn Experiment 1, the PLR of POAG patients was significantly reduced in all conditions, reflecting the defect in photoreception through rods, cones, and ipRGCs. The variable with the highest area under the receiver operating characteristic curve (AUC) was time to max dilation under ipRGC-weighted stimulus, followed by the constriction amplitude under cone-weighted stimulus and the constriction amplitude response to ipRGC-weighted stimuli. The impaired PLR features were associated with greater visual field loss, thinner retinal nerve fiber layer (RNFL) thickness, and cupping of the optic disk. In Experiment 2, IPA and anisocoria duration induced by intermittent blue or red light flashes were significantly greater in participants with POAG than in controls. IPA and anisocoria duration had good diagnostic value, correlating with the inter-eye asymmetry of visual field loss.ConclusionWe demonstrate that binocular chromatic pupillometry could potentially serve as an objective clinical tool for opportunistic glaucoma diagnosis in community-based or telemedicine-based services. Binocular chromatic pupillometry allows an accurate, objective, and rapid assessment of retinal structural impairment and functional loss in glaucomatous eyes of different severity levels.
Novel structured ADAM17 small-molecule inhibitor represses ADAM17/Notch pathway activation and the NSCLC cells’ resistance to anti-tumour drugs
Authors: Chi Meng , Jie Yamin , Li Ying , Wang Duo , Li Man , Li Dan , E Mingyan , Li Yongwu , Liu Na , Gu Anxin , Rong Guanghua 
Published: June 2023

Background and aims: The outcomes of current treatment for non-small cell lung cancer (NSCLC) are unsatisfactory and development of new and more efficacious therapeutic strategies are required. The Notch pathway, which is necessary for cell survival to avert apoptosis, induces the resistance of cancer cells to antitumour drugs. Notch pathway activation is controlled by the cleavage of Notch proteins/receptors mediated by A disintegrin and metalloproteinase 17 (ADAM17); therefore, ADAM17 is a reliable intervention target for anti-tumour therapy to overcome the drug resistance of cancer cells. This work aims to develop and elucidate the activation of Compound 2b, a novel-structured small-molecule inhibitor of ADAM17, which was designed and developed and its therapeutic efficacy in NSCLC was assessed via multi-assays.Methods and results: A lead compound for a potential inhibitor of ADAM17 was explored via pharmacophore modelling, molecular docking, and biochemical screening. It was augmented by substituting two important chemical groups [R1 and R2 of the quinoxaline-2,3-diamine (its chemical skeleton)]; subsequently, serial homologs of the lead compound were used to obtain anoptimized compound (2b) with high inhibitory activity compared with leading compound against ADAM17 to inhibit the cleavage of Notch proteins and the accumulation of the Notch intracellular domain in the nuclei of NSCLC cells. The inhibitory activity of compound 2b was demonstrated by quantitative polymerase chain reaction and Western blotting. The specificity of compound 2b on ADAM17 was confirmed via point-mutation. Compound 2b enhanced the activation of antitumor drugs on NSCLC cells, in cell lines and nude mice models, by targeting the ADAM17/Notch pathway.Conclusion: Compound 2b may be a promising strategy for NSCLC treatment.
Identifying subgroups of patients with type 2 diabetes based on real-world traditional chinese medicine electronic medical records
Authors: Zhao Shuai , Li Hengfei , Jing Xuan , Zhang Xuebin , Li Ronghua , Li Yinghao , Liu Chenguang , Chen Jie , Li Guoxia , Zheng Wenfei , Li Qian , Wang Xue , Wang Letian , Sun Yuanyuan , Xu Yunsheng , Wang Shihua 
Published: June 2023

Introduction: Type 2 diabetes (T2D) is a multifactorial complex chronic disease with a high prevalence worldwide, and Type 2 diabetes patients with different comorbidities often present multiple phenotypes in the clinic. Thus, there is a pressing need to improve understanding of the complexity of the clinical Type 2 diabetes population to help identify more accurate disease subtypes for personalized treatment.Methods: Here, utilizing the traditional Chinese medicine (TCM) clinical electronic medical records (EMRs) of 2137 Type 2 diabetes inpatients, we followed a heterogeneous medical record network (HEMnet) framework to construct heterogeneous medical record networks by integrating the clinical features from the electronic medical records, molecular interaction networks and domain knowledge.Results: Of the 2137 Type 2 diabetes patients, 1347 were male (63.03%), and 790 were female (36.97%). Using the HEMnet method, we obtained eight non-overlapping patient subgroups. For example, in H3, Poria, Astragali Radix, Glycyrrhizae Radix et Rhizoma, Cinnamomi Ramulus, and Liriopes Radix were identified as significant botanical drugs. Cardiovascular diseases (CVDs) were found to be significant comorbidities. Furthermore, enrichment analysis showed that there were six overlapping pathways and eight overlapping Gene Ontology terms among the herbs, comorbidities, and Type 2 diabetes in H3.Discussion: Our results demonstrate that identification of the Type 2 diabetes subgroup based on the HEMnet method can provide important guidance for the clinical use of herbal prescriptions and that this method can be used for other complex diseases.
Home-literacy environments and language development in toddlers with Down syndrome
Authors: Dulin Madison S. , Loveall Susan J. , Mattie Laura J. 
Published: June 2023

IntroductionThe present study aimed to (1) characterize the home-literacy environments (HLE) of toddlers with Down syndrome (DS) and (2) examine if richness of the HLE, child engagement during shared storybook reading activities, quality of a caregiver-child shared storybook reading activity, and exposure to language in the home environment predicted child receptive vocabulary concurrently (Time 1) and 6 months later (Time 2).MethodsParticipants were toddlers with DS (n= 13 at Time 1, 11–29 months of age;n= 10 at Time 2) and their mothers. Mothers completed aHome Literacy Environment Questionnaireat Time 1, which was used to characterize the HLE and to calculate two composite variables: richness of the HLE and child engagement in shared storybook reading. Also at Time 1, the home language environment was measured using adult word count from the LENA Recorder DLP©. The LENA was also used to audio-record and capture the quality of a caregiver-child storybook reading task in the child’s home using the bookDear Zoo. At both time points, mothers completed theMacArthur-Bates Communicative Development Inventories, and the number of words understood variable was used to measure receptive vocabulary.Results/DiscussionResults indicated that toddlers with DS experience rich HLEs and interactive shared storybook reading encounters with their mothers. A multiple linear regression revealed that child engagement and the home language environment correlated with both toddlers’ concurrent and later receptive vocabularies, while the richness of the HLE and the shared storybook reading task emerged as moderate predictors of receptive vocabulary 6 months later.
Traumatic stress symptoms and PTSD risk in children served by Children’s Advocacy Centers
Authors: McGuier Elizabeth A. , Campbell Kristine A. , Byrne Kara A. , Shepard Lindsay D. , Keeshin Brooks R. 
Published: June 2023

PurposeChildren who experience maltreatment are at high risk for posttraumatic stress disorder (PTSD). Children’s Advocacy Centers (CACs) can facilitate access to treatment following maltreatment allegations. We describe PTSD symptoms and intervention decision-making for children served by CACs.MethodsChildren served by CACs in a single state were screened for PTSD symptoms using a structured mental health screening/referral protocol. CAC staff used an electronic form that provided guidance for decision-making. We examined descriptive statistics for PTSD symptoms and risk and tested associations between child characteristics and symptoms. We described CAC staff’s delivery of brief interventions and referral decisions and tested associations with child characteristics and symptoms.ResultsTwo thousand and three hundred fifty children completed screening between 2018 and 2020. Almost half (45.5%) exhibited traumatic stress symptoms suggesting high probability of PTSD at the time of their CAC visit. Children who identified as female or transgender male and older children were more likely to be at high risk for PTSD. Brief interventions were delivered to 66% of children, and most were referred to evidence-based trauma treatment (53.1%) or community mental health services (39.0%). Categorization as moderate or high PTSD risk was associated with a higher likelihood of brief intervention delivery and referral to trauma treatment.ConclusionMany children served by CACs are likely to meet criteria for PTSD at their initial visit. CAC staff demonstrated the ability to deliver brief interventions and make referrals to mental health treatment. Use of structured screening/referral protocols may improve early identification and treatment access for children experiencing PTSD symptoms.
Young people's strategies for navigating education, employment, and housing: a case study from Corby UK
Authors: Barke Jenny , Boelman Victoria , Khairunnisa Vinkha , Shah Salma 
Published: June 2023

IntroductionThis paper reports the findings of research activity carried out as part of the UPLIFT project in Corby, United Kingdom. The project aimed to understand young people's experiences of education, employment and housing, and determine how young people navigate these domains, make choices and develop strategies within what is available to them. Through understanding the opportunities and strategies that young people employ across these domains, our aim was to consider how young people might engage locally to co-create a reflexive policy agenda.MethodsWe worked with peer researchers in Corby and interviewed local people (n= 40) and policy makers (n= 7) about the local context in Corby, and analyzed data, exploring themes.ResultsFindings highlighted the importance of young people understanding how systems work locally and suggest that young people, and their families, need greater support understanding how they can engage with and change systems.DiscussionThere needs to be better, easily accessible guidance developed around the support and opportunities that are available locally. Our research underlines the need to engage with young people in policy making to develop effective robust policy that works in a real-world context.
Literature review and analysis of the social impact of a just energy transition
Authors: Sun Zhonggen , Zhang Furong , Wang Yifei , Shao Ziting 
Published: June 2023

IntroductionThe energy transition is now the focus of global attention. This transition will have a significant impact on the global energy system as well as the political and economic landscape. Research on the social impact of the energy transition can help us get a deeper understanding of the energy transition and propose suggestions for future development.MethodsThis paper focuses on the history and characteristics of the social impact evaluation of the energy transition, using bibliometric methods and the Web of Science Core Collection database with the help of HistCite and VOSviewer analysis tools. This paper discusses what is energy transition, just energy transition and its social impact and how to assess social impacts of just energy transition. In order to reduce the negative impacts of energy transition, interdisciplinary research, social impact research and social impact assessment of construction projects are three directions to be discussed.ResultsThe study find that existing research mainly focuses on the connotation, pathways and different types of a just energy transition. There are three hot areas of research on the impact of a just energy transition: the sustainable development of energy, political economy and society. There is a general lack of research on the social impact of a just energy transition and an even greater lack of relevant research on social impact evaluation.DiscussionBased on the global goal of just energy transition, this paper makes specific recommendations on what developed and developing countries, as well as sectors and enterprises within countries, should do.
Influence of Asafoetida Extract on the Virulence of the Entomopathogenic Nematode Steinernema carpocapsae and Its Symbiotic Bacterium Xenorhabdus nematophila in the Host Pyrrhocoris apterus
Authors: Shaik Haq Abdul , Mishra Archana 
Published: June 2023

Nematode–microbe symbiosis plays a key role in determining pathogenesis against pests. The modulation of symbiotic bacteria may affect the virulence of entomopathogenic nematodes (EPNs) and the biological management of pests. We tested the influence of asafoetida (ASF) extract on the virulence of Steinernema carpocapsae and its symbiotic bacterium, Xenorhabdus nematophila, in Pyrrhocoris apterus. A total of 100 mg of ASF killed 30% of EPNs in 48 h, while P. apterus remained unaffected. The EPNs pre-treated with 100 mg of ASF influenced P. apterus’s mortality by 24–91.4% during a period of 24 to 72 h. The topical application of ASF acted as a deterrent to S. carpocapsae, lowering host invasion to 70% and delaying infectivity with 30% mortality for 168 h. Interestingly, Steinernema’s symbiotic bacterium, Xenorhabdus, remained unaffected by ASF. An in vitro turbidity test containing 100 mg of ASF in a medium increased the growth rate of Xenorhabdus compared to a control. A disc diffusion assay confirmed the non-susceptibility of Xenorhabdus to ASF compared to a positive control, streptomycin. Pro-phenol oxidase (PPO) and phenol oxidase (PO) upregulation showed that ASF influences immunity, while EPN/ASF showed a combined immunomodulatory effect in P. apterus. We report that ASF modulated the virulence of S. carpocapsae but not that of its symbiotic bacterium, X. nematophila, against P. apterus.
Extraction Potential of Lolium perenne L. (Perennial Rye Grass) for Metals in Landfill Soil: Its Tolerance and Defense Strategies
Authors: Masotla Mmatsheko Kgaladi Leah , Melato Funzani Asnath , Mokgalaka-Fleischmann Ntebogeng Sharon 
Published: June 2023

Landfill sites open and close frequently throughout the world, taking over a significant amount of land and leaving it contaminated and unavailable to the surrounding population for use. Different forms of remediation methods have been employed to rehabilitate contaminated land to a state that poses less of a threat to the environment. Phytoremediation is one of the remediation techniques that has proven to be effective, economical and easier to implement compared to other methods. The main aim of this study was to explore the potential use of Lolium perenne L. to remediate and restore metal-contaminated landfill soil and determine its stress tolerance mechanism(s). The metal uptake, determined using inductively coupled plasma-optical emission spectroscopy (ICP-OES) and inductively coupled plasma-mass spectroscopy (ICP-MS), revealed that Lolium perenne accumulate a higher amount of metals in the roots than in leaves, which was further confirmed by the translocation factor (TF) values of all of the metals that were below 1, ranging between 0.2 and 0.8, while Cu, Cr and Pb had a bioaccumulation factor (BCF) > 1. This confirms that L. perenne is capable of absorbing metals into the root matrix but might restrict further movement into other parts of the plant as a defense mechanism against metal toxicity. In response to metal-induced stress, L. perenne displayed an increase in enzyme activity of superoxide dismutase, glutathione S-transferase, peroxidase and amylases in plants grown in landfill soil. Peroxidases displayed the highest level of enzyme activity, while total amylolytic activity had the most significant increase in activity over time. Although not a hyperaccumulator, L. perenne is a potential candidate for the phytoremediation of landfill soil and the phytostabilization of Cu, Cr and Pb.