bluuebunny/crossref_metadata_2025_split huggingface dataset:
A BayeSN distance ladder: H0 from a consistent modelling of Type Ia supernovae from the optical to the near-infrared
Authors: Dhawan Suhail , Thorp Stephen , Mandel Kaisey S , Ward Sam M , Narayan Gautham , Jha Saurabh W , Chant Thaisen 
Published: May 2023

ABSTRACT
The local distance ladder estimate of the Hubble constant (H0) is important in cosmology, given the recent tension with the early universe inference. We estimate H0 from the Type Ia supernova (SN Ia) distance ladder, inferring SN Ia distances with the hierarchical Bayesian SED model, BayeSN. This method has a notable advantage of being able to continuously model the optical and near-infrared (NIR) SN Ia light curves simultaneously. We use two independent distance indicators, Cepheids or the tip of the red giant branch (TRGB), to calibrate a Hubble-flow sample of 67 SNe Ia with optical and NIR data. We estimate H0 = 74.82 ± 0.97 (stat) $\pm \, 0.84$ (sys) km ${\rm s}^{-1}\, {\rm Mpc}^{-1}$ when using the calibration with Cepheid distances to 37 host galaxies of 41 SNe Ia, and 70.92 ± 1.14 (stat) $\pm \, 1.49$ (sys) km ${\rm s}^{-1}\, {\rm Mpc}^{-1}$ when using the calibration with TRGB distances to 15 host galaxies of 18 SNe Ia. For both methods, we find a low intrinsic scatter σint ≲ 0.1 mag. We test various selection criteria and do not find significant shifts in the estimate of H0. Simultaneous modelling of the optical and NIR yields up to ∼15 per cent reduction in H0 uncertainty compared to the equivalent optical-only cases. With improvements expected in other rungs of the distance ladder, leveraging joint optical-NIR SN Ia data can be critical to reducing the H0 error budget.
Resistive heating induced by streaming cosmic rays around a galaxy in the early Universe
Authors: Yokoyama Shota L , Ohira Yutaka 
Published: May 2023

ABSTRACTIt is expected that cosmic rays (CRs) escape from high-redshift galaxies at redshift z ∼ 10–20 because CRs are accelerated by supernova remnants of the first stars. Although ultraviolet and X-ray photons are widely considered the main source of heating of the intergalactic medium, CRs can also contribute to it. When the CRs propagate in the intergalactic medium, in addition to the heating process due to CR ionization, resistive heating occurs due to the electron return current induced by the streaming CRs. We evaluate the heating rate around a galaxy as a function of the distance from the galaxy. We find that the resistive heating induced by CRs dominates over the other heating processes in the vicinity of the galaxy ($r \lesssim 10^2 \, \mathrm{kpc}$) until the temperature reaches $T\sim 10^4 \, \mathrm{K}$. We also recalculate the strength of the magnetic field generated by streaming CRs under the presence of X-ray heating and show that achieved strength can be about one order of magnitude smaller when the X-ray heating is included. The presence of the ‘first’ CRs could be confirmed from the characteristic signature of CR heating imprinted on the 21-cm line map in future radio observations.
Exploring the centre of mass properties of LG-like galaxies
Authors: Salomon Jean-Baptiste , Libeskind Noam , Hoffman Yehuda 
Published: May 2023

ABSTRACT
From high resolution cosmological simulations of the Local Group in a realistic environment, namely HESTIA simulations, we study the position and kinematic deviations that may arise between the disc of a Milky Way (or Andromeda)-like galaxy and its halo. We focus on the three-dimensional analysis of the centres of mass (COM). The study presents two parts. We first consider individual particles to track down the nature and amplitude of the physical deviations of the COM with respect to the distance from the disc centre. Dark matter dominates the behaviour of the COM of all particles at all distances. But the total COM is also very close to the COM of stars. In the absence of a significant merger, the velocity offsets are marginal (10 km s−1) but the positional shifts can be important compared to the disc characteristics (&gt;10 kpc). In the event of a massive accretion, discrepancies are of the same order as the recent finding for the MW under the Magellanic Clouds influence. In a second part, the accent is put on the study of various populations of subhaloes and satellites. We show that satellites properly represent the entire subhalo population. There exists strong mismatch in phase space between the satellites’ COM and the host disc. Moreover, the results are highly inhomogeneous between the simulations and thus, between the accretion histories. Finally, we point out that these shifts are mainly due to a few of the most massive objects.
Searching for single-frame rapid X-ray transients detected withChandra
Authors: Zhang Yijia , Feng Hua 
Published: May 2023

ABSTRACTWe propose a new method to identify rapid X-ray transients observed with focusing telescopes. They could be statistically significant if three or more photons are detected with Chandra in a single CCD frame within a point-spread-function region out of quiescent background. In the Chandra archive, 11 such events are discovered from regions without point-like sources, after discrimination of cosmic rays and background flares and control of false positives. Among them, two are spatially coincident with extended objects in the Milky Way, one with the Small Magellanic Cloud, and another one with M31; the rest have no or a dim optical counterpart (≳20 mag), and are not clustered on the Galactic plane. Possible physical origins of the rapid transients are discussed, including short gamma-ray bursts (GRBs), short-lived hypermassive neutron stars produced by merger of neutron stars, accreting compact objects in the quiescent state, magnetars, and stellar flares. According to the short GRB event rate density, we expect to have detected $2.3_{-0.6}^{+0.7}$ such events in the Chandra archive. This method would also allow us to reveal quiescent black holes with only a few photons.
Resolving a merger in a hyperluminous submillimeter galaxy at z = 2.82
Authors: Perry R W , Chapman S C , Smail Ian , Bertoldi F 
Published: May 2023

ABSTRACT
We present the resolved properties of the z = 2.82 hyperluminous infrared Galaxy (HyLIRG) HS1700.850.1, the brightest 850 $\mu$m source found in the SCUBA-2 followup to the Keck Baryonic Structure Survey fields (S850$\mu$m =19.5 mJy), and amongst the most luminous starbursts known at any redshift.- Using the IRAM-NOEMA interferometer in the highest resolution A-configuration, we resolve the source into two components separated by ∼8 kpc, visible as blue shifted and red shifted 12CO(5–4) lines, exhibiting the expected kinematic properties of a major merger between two gas rich Galaxies. The combined merger system is traced over 2.3 arcsec or 18.4 kpc. Each component of the merger shows ordered gas motions suggestive of a massive turbulent disc. We measure the dynamical masses of the blue and red discs as (1.5 ± 0.2) × 1011 and (0.71 ± 0.22) × 1011 M⊙, respectively. The more massive disc component shows broad wings in the CO line, offset by ∼3 kpc from the disc centroid along the major axis, and extending to velocities ∼±1000 km $\rm {s^{-1}}$ from systemic velocity. We interpret this as either a possible bipolar outflowing component, or more likely a warping or tidal structure in the CO disc. Comparing the properties of HS1700.850.1 to other submillimeter detected galaxies with comparably bright 850 $\mu$m luminosities suggests that ongoing gas-rich mergers, or at least a clustered/group environment lead to these most extreme starburst phases.
Delayed Antarctic melt season reduces albedo feedback
Authors: Liang Lei , Guo Huadong , Liang Shuang , Li Xichen , Moore John C , Li Xinwu , Cheng Xiao , Wu Wenjin , Liu Yan , Rinke Annette , Jia Gensuo , Pan Feifei , Gong Chen 
Published: May 2023

ABSTRACT
Antarctica's response to climate change varies greatly both spatially and temporally. Surface melting impacts mass balance and also lowers surface albedo. We use a 43-year record (from 1978 to 2020) of Antarctic snow melt seasons from space-borne microwave radiometers with a machine-learning algorithm to show that both the onset and the end of the melt season are being delayed. Granger-causality analysis shows that melt end is delayed due to increased heat flux from the ocean to the atmosphere at minimum sea-ice extent from warming oceans. Melt onset is Granger-caused primarily by the turbulent heat flux from ocean to atmosphere that is in turn driven by sea-ice variability. Delayed snowmelt season leads to a net decrease in the absorption of solar irradiance, as a delayed summer means that higher albedo occurs after the period of maximum solar radiation, which changes Antarctica's radiation balance more than sea-ice cover.
Exploring the vacuum ultraviolet photochemistry of astrochemically important triatomic molecules
Authors: Chang Yao , Ashfold Michael N R , Yuan Kaijun , Yang Xueming 
Published: May 2023

ABSTRACT
The recently constructed vacuum ultraviolet (VUV) free electron laser (FEL) at the Dalian Coherent Light Source (DCLS) is yielding a wealth of new and exquisitely detailed information about the photofragmentation dynamics of many small gas-phase molecules. This Review focuses particular attention on five triatomic molecules—H2O, H2S, CO2, OCS and CS2. Each shows excitation wavelength-dependent dissociation dynamics, yielding photofragments that populate a range of electronic and (in the case of diatomic fragments) vibrational and rotational quantum states, which can be characterized by different translational spectroscopy methods. The photodissociation of an isolated molecule from a well-defined initial quantum state provides a lens through which one can investigate how and why chemical reactions occur, and provides numerous opportunities for fruitful, synergistic collaborations with high-level ab initio quantum chemists. The chosen molecules, their photofragments and the subsequent chemical reaction networks to which they can contribute are all crucial in planetary atmospheres and in interstellar and circumstellar environments. The aims of this Review are 3-fold: to highlight new photochemical insights enabled by the VUV-FEL at the DCLS, notably the recently recognized central atom elimination process that is shown to contribute in all of these triatomic molecules; to highlight some of the potential implications of this rich photochemistry to our understanding of interstellar chemistry and molecular evolution within the universe; and to highlight other and future research directions in areas related to chemical reaction dynamics and astrochemistry that will be enabled by increased access to VUV-FEL sources.
Mass-Observation and Vernacular Politics at the 1945 General Election
Authors: Goldsmith Rebecca 
Published: May 2023

Abstract
This article sheds fresh light on popular attitudes towards politics in the 1940s. It does so by reading against the grain of archived material from Mass-Observation’s (M-O) study of the 1945 General Election, as it played out in the constituency of Fulham East. Where the formal reports from this investigation have underpinned influential accounts of ‘apathy’ in 1945, this article returns to the original field notes from the investigation. By attending to the framing of the M-O encounter in Fulham, it suggests that we can reinterpret seemingly apathetic responses as a reaction to the alienating high expectations underpinning the M-O questionnaire, exacerbated by the classed and gendered dynamics of the interview. In other instances, however, it argues displays of apathy or ignorance could indicate the popular delimiting of an appropriate level of political interest, confining this to voting, in contrast to the importance of critical, detailed ‘study’ of politics implicit within the questionnaire. The article consequently contributes to the ongoing discussions surrounding the re-use of archived social-science material by suggesting that we can only rely on such material to gain access to ‘vernacular’ attitudes when we reckon with its fundamentally mediated nature, framed by the assumptions and intersubjective dynamics of the social-science encounter. In turn, it offers an example of how recent interest in the vernacular might be combined with an older, more traditional form of political history, centred on elections.
A flexible model-free tram signal priority method with a large coordination scope in China
Authors: Wang Shan 
Published: May 2023

Abstract
Tram systems with the advantages of reliable operation, comfort, low emissions and moderate capacity have been quite popular in recent years in China. However, there are still problems with tram signal control (e.g. evaluation model, signal control strategies). In-depth analysis on existing operational issues of trams, calculation of two evaluation indexes, as well as a flexible model-free tram signal priority method were developed to deal with tram problems. Empirical research in Songjiang District, Shanghai shows that: (1) The function of the green extension strategy is limited with c.a. 10% tram priority improvement, while the optimal one can reach to 85% higher on average. (2) A scheme with a benefit for trams and with no negative impact, and even benefits, for general traffic can be realized. (3) The optimal solution is beneficial for intersections with a maximum c.a. 70% amelioration with delay decreasing from 132.7 s/vehicle to 40.89 s/vehicle, or from 104.77 s/capita to 22.31 s/capita. This paper has great significance for the signal optimization and safety of tram systems, even the development of a comprehensive transportation system for a city.
Host Specificity Controlled by PWL1 and PWL2 Effector Genes in the Finger Millet Blast Pathogen Magnaporthe oryzae in Eastern Africa
Authors: Masaki Hosea Isanda , de Villiers Santie , Qi Peng , Prado Kathryn A. , Kaimenyi Davies Kiambi , Tesfaye Kassahun , Alemu Tesfaye , Takan John , Dida Mathews , Ringo Justin , Mbinda Wilton , Khang Chang Hyun , Devos Katrien M. 
Published: May 2023

Magnaporthe oryzae, a devastating pathogen of finger millet ( Eleusine coracana), secretes effector molecules during infection to manipulate host immunity. This study determined the presence of avirulence effector genes PWL1 and PWL2 in 221 Eleusine blast isolates from eastern Africa. Most Ethiopian isolates carried both PWL1 and PWL2. Kenyan and Ugandan isolates largely lacked both genes, and Tanzanian isolates carried either PWL1 or lacked both. The roles of PWL1 and PWL2 towards pathogenicity on alternative chloridoid hosts, including weeping lovegrass ( Eragrostis curvula), were also investigated. PWL1 and PWL2 were cloned from Ethiopian isolate E22 and were transformed separately into Ugandan isolate U34, which lacked both genes. Resulting transformants harboring either gene gained varying degrees of avirulence on Eragrostis curvula but remained virulent on finger millet. Strains carrying one or both PWL1 and PWL2 infected the chloridoid species Sporobolus phyllotrichus and Eleusine tristachya, indicating the absence of cognate resistance ( R) genes for PWL1 and PWL2 in these species. Other chloridoid grasses, however, were fully resistant, regardless of the presence of one or both PWL1 and PWL2, suggesting the presence of effective R genes against PWL and other effectors. Partial resistance in some Eragrostis curvula accessions to some blast isolates lacking PWL1 and PWL2 also indicated the presence of other interactions between fungal avirulence ( AVR) genes and host resistance ( R) genes. Related chloridoid species thus harbor resistance genes that could be useful to improve finger millet for blast resistance. Conversely, loss of AVR genes in the fungus could expand its host range, as demonstrated by the susceptibility of Eragrostis curvula to finger millet blast isolates that had lost PWL1 and PWL2. [Formula: see text] Copyright © 2023 The Author(s). This is an open access article distributed under the CC BY 4.0 International license .
Chronic activation of tubulin tyrosination in HCM mice and in human iPSC-engineered heart tissues improves heart function
Authors: Pietsch Niels , Chen Christina Y. , Kupsch Svenja , Bacmeister Lucas , Geertz Birgit , Herrera-Rivero Marisol , Voß Hanna , Krämer Elisabeth , Braren Ingke , Westermann Dirk , Schlüter Hartmut , Mearini Giulia , Schlossarek Saskia , van der Velden Jolanda , Caporizzo Matthew , Lindner Diana , Prosser Benjamin L. , Carrier Lucie 
Published: May 2023

AbstractRationaleHypertrophic cardiomyopathy (HCM) is the most common cardiac genetic disorder caused by sarcomeric gene variants and associated with left ventricular (LV) hypertrophy and diastolic dysfunction. The role of the microtubule network has recently gained interest with the findings that α-tubulin detyrosination (dTyr-tub) is markedly elevated in heart failure. Acute reduction of dTyr-tub by inhibition of the detyrosinase (VASH/SVBP complex) or activation of the tyrosinase (tubulin tyrosine ligase, TTL) markedly improved contractility and reduced stiffness in human failing cardiomyocytes, and thus poses a new perspective for HCM treatment.ObjectiveIn this study, we tested the impact of chronic tubulin tyrosination in a HCM mouse model (Mybpc3-knock-in; KI), in human HCM cardiomyocytes and in SVBP-deficient human engineered heart tissues (EHTs).Methods and ResultsAAV9-mediated TTL transfer was applied in neonatal wild-type (WT) rodents and 3-week-old KI mice and in HCM human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes. We show that i) TTL for 6 weeks dose-dependently reduced dTyr-tub and improved contractility without affecting cytosolic calcium transients in WT cardiomyocytes; ii) TTL for 12 weeks improved diastolic filling, cardiac output and stroke volume and reduced stiffness in KI mice; iii) TTL for 10 days normalized cell hypertrophy in HCM hiPSC-cardiomyocytes; iv) TTL induced a marked transcription and translation of several tubulins and modulated mRNA or protein levels of components of mitochondria, Z-disc, ribosome, intercalated disc, lysosome and cytoskeleton in KI mice; v) SVBP-deficient EHTs exhibited reduced dTyr-tub levels, higher force and faster relaxation than TTL-deficient and WT EHTs. RNA-seq and mass spectrometry analysis revealed distinct enrichment of cardiomyocyte components and pathways in SVBP-KO vs. TTL-KO EHTs.ConclusionThis study provides the first proof-of-concept that chronic activation of tubulin tyrosination in HCM mice and in human EHTs improves heart function and holds promise for targeting the non-sarcomeric cytoskeleton in heart disease.
EXTRACELLULAR PERINEXAL SEPARATION IS A PRINCIPAL DETERMINANT OF CARDIAC CONDUCTION
Authors: Adams William P. , Raisch Tristan B. , Zhao Yajun , Davalos Rafael , Barrett Sarah , King D. Ryan , Bain Chandra B. , Colucci-Chang Katrina , Blair Grace A. , Hanlon Alexandra , Lozano Alicia , Veeraraghavan Rengasayee , Wan Xiaoping , Deschenes Isabelle , Smyth James W. , Hoeker Gregory S. , Gourdie Robert G. , Poelzing Steven 
Published: May 2023

RationaleCardiac conduction is understood to occur through gap junctions. Recent evidence supports ephaptic coupling as another mechanism of electrical communication in heart. Conduction via gap junctions predicts a direct relationship between conduction velocity (CV) and bulk extracellular volume. Ephaptic theory is premised on the existence of a biphasic relationship between CV and the volume of specialized extracellular clefts within intercalated discs.ObjectiveDetermine the relationship between ventricular CV and structural changes to micro and nano-scale extracellular spaces.MethodsConduction and connexin43 (Cx43) gap junction protein expression were quantified from optically mapped guinea pig whole-heart preparations perfused with albumin, mannitol, dextran 70kDa, or dextran 2MDa. Peak sodium current was quantified from isolated guinea pig ventricular myocytes. Extracellular resistance (Re) was quantified by impedance spectroscopy. Intercellular communication was assessed in a heterologous expression system with fluorescence recovery after photobleaching. Perinexal width was quantified from transmission electron micrographs.ResultsCV was significantly reduced by mannitol, and increased by albumin, dextran 70kDa and 2MDa. The combination of albumin and dextran 70kDa decreased CV relative to albumin alone. Rewas reduced by mannitol, not significantly changed by albumin, and increased by both dextran 70kDa and dextran 2MDa. Cx43 gap junction expression and conductance, and peak sodium current were not significantly altered by the osmotic agents. The perinexal width in response to osmotic agents, in order of narrowest to widest, was: albumin with dextran 70kDa, albumin or dextran 2MDa alone, dextran 70kDa or no osmotic agent, and mannitol. When compared in the same order, CV was biphasically related to perinexal width.ConclusionsCardiac conduction does not correlate with bulk tissue impedance, but is biphasically related to perinexal separation, providing evidence that the relationship between CV and extracellular volume in ventricular myocardium is determined by ephaptic mechanisms under conditions of normal gap junctional coupling.
A high-content screen identified ingenol-3-angelate as an enhancer of B7-H3-CAR T cell activity by increasing B7-H3 protein expression on the target cell surface via PKCα activation
Authors: Lee Ha Won , O’Reilly Carla , Beckett Alex N. , Currier Duane G. , Chen Taosheng , DeRenzo Christopher 
Published: May 2023

ABSTRACTCAR T cell therapy is a promising approach to improve outcomes and decrease toxicities for patients with cancer. While extraordinary success has been achieved using CAR T cells to treat patients with CD19-positive malignancies, multiple obstacles have so far limited the benefit of CAR T cell therapy for patients with solid tumors. Novel manufacturing and engineering approaches show great promise to enhance CAR T cell function against solid tumors. However, similar to single agent chemotherapy approaches, CAR T cell monotherapy may be unable to achieve high cure rates for patients with difficult to treat solid tumors. Thus, combinatorial drug plus CAR T cell approaches may ultimately be required to achieve widespread clinical success. In this regard, we developed a novel high-content and high-throughput screen to evaluate 1114 FDA approved drugs to increase expression of the solid tumor antigen B7-H3 in metastatic osteosarcoma cells. In this proof-of-principle screen, we demonstrate that ingenol-3-angelate increased B7-H3 (CD276) mRNA, total protein, and cell surface expression. Mechanistically, ingenol-3-angelate increased B7-H3 expression via protein kinase C alpha activation. Functionally, ingenol-3-angelate induced B7-H3 expression enhanced B7-H3-CAR T cell function, highlighting utility of the approach, and paving the way for expanding this high-throughput and high-content technique to study other tumor and CAR T cell combinations.