bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Effect of the ABCB1 (MDR-1) C3435T Polymorphism in Turkish Patients with Aspirin Resistance in Acute Ischemic Stroke
Authors: Yürek Emrah , Yavuz Burcu Genç , Tanoğlu Esra Guzel , Gürkaş Erdem , Altundağ İbrahim , Yalçınkaya Burhanettin , Yılmaz Erdal , Çolak Şahin 
Published: January 2023

Abstract
Recurrence of thrombotic events during aspirin therapy is known as aspirin resistance (AR). This study aimed to investigate the rate of AR, the factors influencing AR in patients with acute ischemic stroke under regular aspirin use, and the relationship between AR and ABCB1 (MDR-1) C3435T polymorphism. Throughout this multicenter prospective study, 174 patients with acute ischemic stroke who had been prescribed aspirin for at least one month due to the risk of vascular disease, along with 106 healthy volunteers, were included as part of the study group. The results of our study indicate that AR was detected in 21.3% of the patient group. According to the results of an analysis of the polymorphism of the ABCB1 C3435T in patients with AR compared to those with aspirin sensitivity, patients with AR possessed more heterozygous (CT) and homozygous genotypes (TT) than those with aspirin sensitivity (p = 0.001). Based on multivariate logistic regression analysis of factors affecting AR in acute ischemic stroke patients, hypertension (OR: 5.679; 95% CI: 1.144–28.19; p = 0.034), heterozygous (CT) genotype (OR: 2.557; 95% CI: 1.126–5.807; p = 0.025), increased platelet values (OR: 1.005; 95% CI: 1.001–1.009; p = 0.029), and CRP/albumin values (OR: 1.547; 95% CI: 1.005–2.382; p = 0.047) were found to be associated with a greater risk of AR. The presence of heterozygous (CT) genotype in the ABCB1 C3435T gene region in the Turkish population is associated with an increased risk of AR. When planning aspirin therapy, it is crucial to consider the ABCB1 (MDR-1) C3435T polymorphism.
Transcriptome analysis of microRNA and mRNA expression profiles in Preeclampsia
Authors: Ping Zepeng , Feng Ying , Lu Ying , Ai Ling , Jiang Huling 
Published: January 2023

Abstract
Background
Preeclampsia (PE), a pregnancy specific syndrome, is one kind of common gestational hypertension disease, which can cause maternal and perinatal mortality and morbidity. This study was conducted to identify key microRNAs (miRNAs), mRNAs and related signaling pathways in the pathogenesis of PE.
Methods
Whole transcriptome sequencing and small RNA sequencing of the peripheral blood from 3 PE patients and 3 normal pregnant women were performed. Differential expressed (DE) miRNAs were identified using the DEseq2 package. Target genes of the selected upregulated and downregulated DE miRNAs were predicted. Based on the hypergeometric distribution of DE miRNA target genes, we analyzed GO enrichment and KEGG pathway enrichment using R.
Results
Total 1291 and 1281 novel RNAs were obtained from the preeclampsia patients and healthy individuals. 70 miRNAs were screened out with significant levels with 51 significantly upregulated and 19 significantly downregulated. 44306 genes were predicted as the targets of these miRNAs. Besides, KEGG pathway analysis revealed that the upregulated mRNAs were enriched in Glycosaminoglycan biosynthesis-chondroitin sulfate / dermatan sulfate, Base excision repair and the downregulated mRNAs were enriched in Tuberculosis, Phagosome.
Conclusion
We constructed regulatory networks of miRNAs and target genes, there were 2208 negative miRNA-mRNA interactions in total. The network and pathway information illustrate the potential functions of mRNAs and miRNAs in PE pathogenesis.
Revisiting the Kuznets Curve: A New Approach to Describe a Bilateral Nonlinear Kuznets Curve
Authors: Nademi Younes , Kalmarzi Haniyeh Sedaghat 
Published: January 2023

Abstract
The prior studies regarding the Kuznets curve have obtained inconsistent results regarding the existence of the Kuznets curve. One of the possible reasons for this inconsistency might be a specification error in modeling the Kuznets curve. In other words, the one-sided causality from per capita income to inequality might not make sense. In this paper, we assume a two-sided causality in the per capita income-inequality nexus. Also, we assumed a nonlinear relationship between per-capita income and income inequality as a quadratic form of these two variables. In other words, changes in per capita income may have a nonlinear impact on the inequality level, and inequality levels can determine per-capita income in a nonlinear fashion. For justifying this two-sided nonlinear relationship which means a bilateral nonlinear Kuznets curve, firstly, we have reviewed the literature to explain this type of per capita income-inequality nexus. Second, we have justified this nonlinear relationship by the wavelet coherence approach and finally, we have applied our hypothesis in a dynamic simultaneous panel data model with a quadratic form of both per capita income and inequality. We have used two samples of countries, including G7 + BRICS during 1970–2019, and 129 countries consist of both developing and developed countries during the period of 1980–2019. The empirical results of the wavelet coherence approach indicate that there are two different phases including the same-phase and opposite phase in different time horizons which might reflect the possibility of a nonlinear relationship in per capita income-inequality nexus as well as a two sided causality between per capita income and inequality. Finally, we have estimated different simultaneous equations with different inequality indexes during the different periods using the GMM method. The empirical results indicate that there is a bilateral nonlinear relationship in per capita income-inequality nexus in both samples and different periods. In other words, the results support a bilateral nonlinear Kuznets curve.
JEL Classification: D63, D31, C49, C33
Comparison between intra and postoperative outcomes of the da Vinci SP and da Vinci Xi robotic platforms in patients undergoing radical prostatectomy
Authors: Moschovas Marcio Covas , Loy David , Patel Evan , Sandri Marco , Moser Daniel , Patel Vipul 
Published: January 2023

Abstract
Background
The new SP robot incorporates a single trocar that houses a flexible camera and three bi-articulated arms, which minimizes the number of incisions needed to assess the surgical site, allowing for a less invasive procedure.
Objectives
To compare the postoperative pain scale and outcomes in patients with similar demographic characteristics undergoing robotic-assisted radical prostatectomy (RARP) with SP and Xi robots.
Material and Methods
One hundred consecutive patients undergoing RARP with the SP robot were matched, using a propensity score (PS), with 100 patients from a cohort of 1757 who were operated on with the da Vinci Xi from June 2019 to January 2021. We described and compared the perioperative pain scores and outcomes of both groups.
Results
The SP group had less blood loss (50cc vs. 62.5cc, P < 0.001) and longer operative time (114 min. vs. 94 min, P < 0.001). The only period we could show a difference in postoperative pain scores was 6 hours after surgery, with a small advantage for the SP (2 vs. 2.5, P < 0.001). Both groups had satisfactory postoperative continence recovery, 91% vs. 90% for the SP and Xi, respectively. The groups had a mean follow-up of 24.5 and 22 months for SP and Xi, respectively. The tumor stage and percentage of positive surgical margins were similar between groups (15% vs. 15%, P = 1).
Conclusion
Patients undergoing RARP with the SP had longer operative times with less blood loss than the Xi. However, despite the lower number of abdominal incisions on the SP, the groups had similar intraoperative performance, and we were unable to demonstrate clinically significant differences in postoperative pain scores between the groups 6, 12, and 18 hours after surgery.
Reforming of graphite oxide from agro-waste by incorporating nanosilica for the remediation of nitrate and phosphate anions from wastewater
Authors: Fouda Safaa. R. 
Published: January 2023

Abstract
Graphite oxide obtained from the oxidation of sawdust with (0.5 wt%) was immobilized into silica to improve the effectiveness of the silica phase toward depollution. The functional interaction profiles were assessed using XRD and SEM performances. The excess loading of graphite oxide percent encouraged the aggregation of incorporated silica molecules, forming the so-called “colonies”. Such colonies caused marked exfoliation of graphite oxide layers in the as-designed silica @graphite oxide hybrid materials and considerable coalescence of graphite oxide in a silica matrix. The as-designed silica @(0.01) graphite oxide nanocomposites showed pronounced sorption competences for PO4-3 (95%), not the same for NO3- (72%). Such depollution behavior is governed by the interaction profiles including the incorporated graphite oxide and “silica colonies”. The fitness of the kinetic models was ranked as pseudo-first order. The values of ΔHo = 0.824 and 3.58, So = 0.109 and 0.116, and Go = -33.45 to -36.7 kJ/mole for phosphate and nitrate, respectively. The estimated data point to endothermic, spontaneous adsorption in nature.
Construction of the embedded Li 4 Ti 5 O 12 -MWCNTs nanocomposite electrode for diverse applications in electrochemical sensing and rechargeable battery
Authors: Prasad G. Venkata , Reddy T. Madhusudana , Narayana A. Lakshmi , Hussain O. M. , Gopal T. Venu , Shaikshavali P. 
Published: January 2023

Abstract
Here, a facile and cost-effective hydrothermal method was used to synthesize lithium titanate (Li4Ti5O12, (LTO))-multiwalled carbon nanotubes (MWCNTs) nanocomposite for the bifunctional property of sensing and energy storage applications. Transmission electron microscopy (TEM), scanning electron microscopy (SEM), and X-ray diffraction (XRD) were used to confirm the formation of LTO-MWCNTs nanocomposite. The electrochemical sensing of Dopamine (DA) at LTO-MWCNTs modified glassy carbon electrode (GCE) was studied. The modified electrode demonstrated remarkable sensitivity, with a detection limit of 1.54 µM of DA. Moreover, the modified electrode was used for the selective measurement of DA in presence of 5-hydroxytryptamine (5-HT) and folic acid (FA) without interfering with their respective potentials. The modified electrode was used to quantify the DA in commercial DA injection sample with satisfactory recoveries. The modified LTO-MWCNTs/GCE electrode showed acceptable reproducibility and excellent stability. In addition, LTO-MWCNTs nanocomposite electrode delivered a high initial discharge capacity of 176 mAh g− 1 at a charge-discharge rate of 1C in a constant-current charge-discharge experiment, which proved its efficacy as a rechargeable battery anode material.
Ethnopharmacology and Species diversity of Pteridophyta in Cyathea Park, Bali: A Field study and Literature Review
Authors: Juliasih Ni Ketut Ayu , Adnyana I Made Dwi Mertha 
Published: January 2023

Abstract
Pteridophyta has been studied and conserved at the botanical garden. However, few have found and documented the medicinal properties of Pteridophyta species. The study identified species diversity and ethnopharmacology of Pteridophyta collected in Cyathea Park, Bali. Field exploration research and literature review were used in this study. The research was conducted by directly exploring the species of Pteridophyta collected in Cyathea Park, Bali and literature studies on the benefits and ethnopharmacology of Pteridophyta species are used as candidates and raw materials for traditional medicine. Data search is carried out systematically by utilizing databases and keywords. All the data is examined qualitatively and descriptively. The study's findings indicate nine species: Cyathea contaminans (Wall.ex Hook) Copel, Asplenium nidus L., Asplenium sp., Selaginella sp., Diplazium esculentum., Angiopteris evecta (G.Forst.) Hoffm, Cyathea sp., Nephrolepis hirsutula (Forst), and Dicksonia blumei (Kunze) Moore. The leaves and shoots are the most frequently used raw materials in medicine. At the same time, the roots, stems, and hair are utilized in planting mediums, crafts, games, and food production. Pteridophyta species treat fever, cough, anticonvulsant, antibacterial, anti-inflammatory, antipyretic, antidiuretic, antioxidant, insecticide, larvicide, diabetes, and anti-retroviral.
WITHDRAWN: Utility of MRI with QSM in Motor Neuron Disease
Authors: Warner DO Robin 
Published: January 2023

Abstract

22 March, 2024. Editorial note correction. Research Square has withdrawn this preprint after institutional review by Hospital for Special Surgery revealed two inaccurately named co-authors on version 1 who requested removal of their names as they did not agree to preprint posting of this work, and they expressed concerns regarding the reliability of the findings presented in version 1.
20 January, 2023. Please see corrected editorial note above regarding this withdrawal.
Os evangélicos e a disputa pelo poder político no Brasil
Authors: Rezende Dannyel Brunno Herculano , Pimentel Lopes Júnior Orivaldo 
Published: January 2023

A intensa participação evangélica (especialmente os ramos pentecostais e neopentecostais) na política brasileira na última década (re)colocaram em evidência as estreitezas das relações entre religião e política, sendo as últimas eleições presidenciais (2010, 2014 e 2018) significativas nesse sentido, uma vez que o peso da religião e de questões de natureza moral sobre a esfera pública se revelaram de forma contundente. Propomos traçar um panorama histórico acerca da entrada e participação evangélica na política brasileira a nível presidencial, abordando as relações de poder em disputa nesses pleitos presidenciais e apresentando o desenho de um conservadorismo moral evangélico crescente na esfera pública. O texto escrito faz referência aos dados eleitorais, e discute com destacados pesquisadores brasileiros que se debruçaram recentemente sobre a temática de interface religião e política.
Palavras-chave: Religião e política; Evangélicos brasileiros; Eleições presidenciais; Esfera Pública.
FRENTE PARLAMENTAR EVANGÉLICA NO CONGRESSO NACIONAL
Authors: Machado e Rocha Antonia Rozimar , De Sousa e Silva Francisco Samuel , Alves Barreto Amanda 
Published: January 2023

O presente artigo traz à baila a análise da Frente Parlamentar Evangélica no Congresso Nacional (FPE) que reivindica para si o status quo de representante dos evangélicos brasileiros, sendo estes o segmento social que mais cresceu no período intercensitário de 2000 a 2010. A FPE atualmente é composta por 195 deputados e 08 senadores que juntos respondem por um bloco de 20 partidos políticos, sendo uma das bancadas mais atuantes do Congresso Nacional. Portanto, objetiva-se com esta pesquisa analisar o crescimento da FPE e quais as reais influências e controle desta sobre a fidelidade partidária e votos dos seus membros e da comunidade evangélica. A metodologia aplicada é de natureza qualitativa a partir de estudos bibliográfico e documental, sob um prisma histórico-dialético. Pode-se concluir, provisoriamente, que a Frente Parlamentar Evangélica reivindica a outorga da representatividade da comunidade evangélica, mas, na prática, age mais de forma reativa do que propositiva, ademais, não controla majoritariamente os votos dos evangélicos brasileiros.
Palavras-chave: Frente Parlamentar Evangélica. Representatividade Política. Pentecostais e política. Religião.
Recent Avenues in Treatment of Liver Diseases: Role of Nanotechnology
Authors: Nagpal Manju , Bhuyan Madhusmita , Kaur Malkiet , Kaushal Udesh , Singh Manjinder , Aggarwal Geeta 
Published: January 2023

Background:
Worldwide, millions of people are affected by liver disorders and issues,
and the successful treatment of patients seems challenging even after many treatment strategies.
Presently, doctors are left with treatments like liver transplantation and resection. Researchers
found it challenging to target the liver due to various drawbacks such as opsonization, mechanical
entrapment, and RES uptake.

Methods:
Literature (from the past ten years) on different research data on the treatment of liver
diseases and study reports on the development of various nanocarriers targeting the liver have been
collected using multiple search engines such as ScienceDirect, j-gate, google scholar, PubMed, scihub,
etc. and data have been compiled accordingly.

Results:
The basics of liver anatomy and various liver cells and pathophysiology of liver diseases,
and liver targeting have been mentioned better to understand the further treatment of various liver
disorders. Various Liver diseases such as hepatitis B, liver fibrosis, hepatocellular carcinoma, acute
liver failure, and liver cirrhosis have been detailed in multiple research studies related to their treatment.
Various strategies for active and passive liver targeting have also been overviewed. Several
advanced reported nanocarriers (liposomes, polymeric micelles, nanoparticles, micro and nanoemulsions,
and phytosomes) are mentioned and their potential in treating liver disorders has been
summarized by compiling research reports related to these nanocarriers.

Conclusion:
The fabrication of nanomedicine incorporating nanocarriers and biomaterials for treating
liver diseases is a big challenge. Understanding various aspects of liver anatomy and liver cells
is the prime requirement while designing successful liver-targeted nano/microcarriers. Also, the
choice of advanced or modified polymeric material in liver targeting is very crucial for their specific
liver cell targeting, for their biocompatibility and biodegradability point of view.
Compliance to Haemodialysis Regimen among End-stage Renal Disease Patients: A Case Study of three Selected Hospitals in Kwara State, Nigeria
Authors: Akpor Oluwaseyi A. , Yakubu Monsurat O. , Akpor Oghenerobor B. 
Published: January 2023

Aims:
The study investigated the determinants of compliance and outcomes of haemodialysis regimens among patients with end-stage renal disease (ESRD) in Ilorin, Kwara State.

Background:
Chronic kidney disease (CKD), also known as chronic kidney failure, is the persistent decline in glomerular filtration rate (GFR) for more than three months and it often progresses to (ESRD) with permanent loss of kidney function and increased mortality.

Objective:
The study investigated the determinants of compliance and outcomes of haemodialysis regimens among patients with ESRD in Ilorin, Kwara State.

Methods:
Total population and purposive sampling techniques were used to guide the recruitment of 80 participants. The research design was descriptive and cross-sectional research designs using quantitative strategy. Socio-demographic data and compliance level for haemodialysis regimen were determined using standardized questionnaire while biophysical measurements and laboratory investigations were used to determine treatment outcomes. Descriptive and inferential statistics were used for data analysis.

Results:
Findings from the study revealed that 66.3% of the participants were 41 years and above, 45% had up to tertiary education while 76.3% of the participants relied on family members for treatment funding. Regarding treatment compliance, 58.8% and 47.5% had moderate compliance to fluid and diet, respectively. Barriers to compliance were transportation logistics (50%), haemodialysis side effects with machine malfunction (52.2%), changes in lifestyle (50%) and cost (41.3%).

Conclusion:
Exorbitant nature of haemodialysis treatment militated against good outcomes. Thus, nephrology nurses and other healthcare professionals should intensify efforts to promote treatment adherence among patients with ESRD. Government and other policymakers could assist in subsidizing the cost of haemodialysis therapy to aid compliance and improve treatment outcomes. Thereby, promoting patients’ quality of life with a reduction in mortality rate.
Efficacy and safety of urate-lowering therapy in multimorbid patients in real clinical practice: results of clinical study
Authors: Khimion L.V. , Nayshtetik I.M. , Burianov O.A. , Rotova S.O. , Smyian S.I. , Lapshyna H.M. , Danyliuk S.V. , Sytiuk T.O. , Kicha N.V. , Lebedeva T.O. , Trofanchuk V.V. 
Published: January 2023

Background. Clinical studies of urate-lowering therapy (ULT) use in multimorbid patients, including those with chronic kidney disease (CKD), are important in modern medical science. The purpose was to determine the efficacy and safety of ULT in patients with hyperuricemia and comorbid conditions, including people with chronic kidney disease, in real clinical practice. Materials and methods. This prospective comparative clinical study “Liquestia: comparative efficacy and safety in gouty arthritis patients with comorbid diseases and in patients with hyperuricemia and chronic kidney disease” was conducted in real clinical practice with the involvement of 124 patients with hyperuricemia, who were prescribed either febuxostat (Liquestia, JSC “Farmak”/Adenuric, Berlin Chemie) or allopurinol as ULT. Results. Individuals who received febuxostat significantly more often and faster reached the target levels of uric acid compared to patients who underwent treatment by allopurinol, regardless of glomerular filtration rate (GFR), except those from dialysis subgroup, and the presence of comorbidities. Patients in febuxostat subgroups during the study showed an increase in GFR after 6 months of treatment — at the level of the trend in the group with baseline GFR ≥ 60 ml/min and at a statistically significant level — in CKD stage 3–4, which could be the evidence of renoprotective effect of febuxostat with reduced GFR, while people receiving allopurinol tended to further decrease of GFR in 31.8 % of cases. Conclusions. The use of Liquestia for the treatment of patients with hyperuricemia and various comorbid conditions is no less effective than the use of Adenuric and more effective than allopurinol and helps achieve the target levels of uric acid in 90 % of cases within 6 months of treatment, which accompanied by a statistically significant increase in GFR in patients with CKD stage 3–4.