bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influence of selected dosages of plastic microparticles on the porcine fecal microbiome
Authors: Gałęcka Ismena , Rychlik Andrzej , Całka Jarosław 
Published: January 2025

AbstractStudies conducted so far have shown that nano- and microplastic may disturb the intestinal microenvironment by interacting with the intestinal epithelium and the gut microbiota. Depending on the research model used, the effect on the microbiome is different—an increase or decrease in selected taxa resulting in the development of dysbiosis. Dysbiosis may be associated with intestinal inflammation, development of mental disorders or diabetes. The aim of the study was to analyze the intestinal microbiome in 15 gilts divided into 3 research groups (n = 5; control group, receiving micropartices at a dose 0.1 g/day (LD) and 1 g/day (HD)). Feaces were collected before and after 28 days of exposure to PET microplastics. The analysis of the intestinal microbiome was performed using next-generation sequencing. Alpha and beta diversity indices were compared, showing, that repetition affected only the abundance indices in the control and LD groups, but not in the HD group. The relationships between the number of reads at the phylum, genus and species level and the microplastic dose were calculated using statistical methods (r-Pearson correlation, generalized regression model, analysis of variance). The statistical analysis revealed, that populations of Family XIII AD3011 group, Coprococcus, V9D2013 group, UCG-010 and Sphaerochaeta increased with increasing MP-PET dose. The above-mentioned taxa are mainly responsible for the production of short-chain fatty acids (SCFA). It may be assumed, that SCFA are one of the mechanisms involved in the response to oral exposure to MP-PET.
Ten-year outcomes after DMEK, DSAEK, and PK: insights on graft survival, endothelial cell density loss, rejection and visual acuity
Authors: Wilhelm Theresa Isabelle , Gauché Laura , Böhringer Daniel , Maier Philip , Heinzelmann Sonja , Glegola Mateusz , Kammrath Betancor Paola , Reinhard Thomas 
Published: January 2025

AbstractFuchs Endothelial Corneal Dystrophy (FECD) is the most frequent indication for corneal transplantation, with Descemet membrane endothelial keratoplasty (DMEK), Descemet stripping automated endothelial keratoplasty (DSAEK), and penetrating keratoplasty (PK) being viable options. This retrospective study compared 10-year outcomes of these techniques in a large cohort of 2956 first-time keratoplasty eyes treated for FECD at a high-volume corneal transplant center in Germany. While DMEK and DSAEK provided faster visual recovery (median time to BSCVA ≥ 6/12 Snellen: DMEK 7.8 months, DSAEK 12.4 months, PK 37.9 months; cumulative probability of BSCVA ≥ 6/12 Snellen within 5 years: DMEK 93%, DSAEK 83%, PK 63%), PK surprisingly exhibited superior long-term graft survival (92% vs. 75% for DMEK and 73% for DSAEK at 10 years). Endothelial cell density (ECD) decreased significantly faster after DMEK and DSAEK, potentially contributing to their lower graft survival (10-year ECD > 1000 cells/mm2 probability: DMEK 3%, DSAEK 8%, PK 18%). DMEK demonstrated the lowest rejection rate (10% at 10 years vs. 13% for PK and 19% for DSAEK). These findings challenge the perceived superiority of endothelial keratoplasty and highlight the need for further investigation into the long-term implications of accelerated endothelial cell loss after DMEK and DSAEK.
Evaluation of fatigue performance of asphalt materials based on their relaxation behavior
Authors: Zhang Beibei , Jing Mengqi 
Published: January 2025

AbstractAlthough the fatigue properties of asphalt materials have been extensively studied, the relationship between the rheological properties and road performance of asphalt mixtures remains underexplored. In this study, we have examined the relaxation properties of asphalt binders through relaxation tests conducted on asphalt and its mastic under different conditions. A repeated stress relaxation-recovery test is designed for assessing both the relaxation and elastic properties, and a set of reasonable test parameters is recommended, thereby establishing a novel test method for measuring the relaxation and elastic behaviors of asphalt. In addition, we have proposed evaluation indexes, such as relaxation time, relaxation rate, and strain recovery rate, to assess the stress relaxation performance and strain recovery ability. It is observed that the relaxation rate and strain recovery rate of the material can be used to characterize the material’s relaxation and elasticity properties, respectively. Thus, the proposed indexes can be used to comprehensively evaluate the viscoelastic performance of the material. The fatigue performance of the selected materials is further examined using the linear amplitude sweep (LAS) test, and the correlation between the relaxation properties and fatigue performance (as indicated by fatigue parameters) is explored. Furthermore, a fatigue performance prediction equation based on the repetitive stress relaxation-recovery test is established. The findings reveal a strong correlation between the relaxation properties and fatigue performance, suggesting that the stress relaxation test can accurately assess the fatigue performance of asphalt materials.
Classifying synoptic patterns driving tornadic storms and associated spatial trends in the United States
Authors: Jiang Qin , Dawson II Daniel T. , Li Funing , Chavas Daniel R. 
Published: January 2025

AbstractSevere convective storms and tornadoes rank among nature’s most hazardous phenomena, inflicting significant property damage and casualties. Near-surface weather conditions are closely governed by large-scale synoptic patterns. It is crucial to delve into the involved multiscale associations to understand tornado potential in response to climate change. Using clustering analysis, this study unveils that leading synoptic patterns driving tornadic storms and associated spatial trends are distinguishable across geographic regions in the U.S. Synoptic patterns with intense forcing featured by intense upper-level eddy kinetic energy and a dense distribution of Z500 fields dominate the increasing trend in tornado frequency in the southeast U.S., generating more tornadoes per event. Conversely, the decreasing trend noted in certain regions of the central Great Plains is associated with weak upper-level synoptic forcing. These findings offer an explanation of observational changes in tornado occurrences, suggesting that the physical mechanisms driving those changes differ across regions.
Endothelial tip-cell position, filopodia formation and biomechanics require BMPR2 expression and signaling
Authors: Hiepen Christian , Benamar Mounir , Barrasa-Fano Jorge , Condor Mar , Ilhan Mustafa , Münch Juliane , Hastar Nurcan , Kerkhoff Yannic , Harms Gregory S. , Mielke Thorsten , Koenig Benjamin , Block Stephan , Rocks Oliver , Abdelilah-Seyfried Salim , Van Oosterwyck Hans , Knaus Petra 
Published: January 2025

AbstractBlood vessel formation relies on biochemical and mechanical signals, particularly during sprouting angiogenesis when endothelial tip cells (TCs) guide sprouting through filopodia formation. The contribution of BMP receptors in defining tip-cell characteristics is poorly understood. Our study combines genetic, biochemical, and molecular methods together with 3D traction force microscopy, which reveals an essential role of BMPR2 for actin-driven filopodia formation and mechanical properties of endothelial cells (ECs). Targeting of Bmpr2 reduced sprouting angiogenesis in zebrafish and BMPR2-deficient human ECs formed fewer filopodia, affecting cell migration and actomyosin localization. Spheroid assays revealed a reduced sprouting of BMPR2-deficient ECs in fibrin gels. Even more strikingly, in mosaic spheroids, BMPR2-deficient ECs failed to acquire tip-cell positions. Yet, 3D traction force microscopy revealed that these distinct cell behaviors of BMPR2-deficient tip cells cannot be explained by differences in force-induced matrix deformations, even though these cells adopted distinct cone-shaped morphologies. Notably, BMPR2 positively regulates local CDC42 activity at the plasma membrane to promote filopodia formation. Our findings reveal that BMPR2 functions as a nexus integrating biochemical and biomechanical processes crucial for TCs during angiogenesis.
Phosphorylation of endothelial histone H3.3 serine 31 by PKN1 links flow-induced signaling to proatherogenic gene expression
Authors: Jin Young-June , Liang Guozheng , Li Rui , Wang ShengPeng , Alnouri Mohamad Wessam , Bentsen Mette , Kuenne Carsten , Günther Stefan , Yan Yang , Li Yongxin , Wettschureck Nina , Offermanns Stefan 
Published: January 2025

Abstract
Atherosclerotic lesions develop preferentially in arterial regions exposed to disturbed blood flow, where endothelial cells acquire an inflammatory phenotype. How disturbed flow induces endothelial cell inflammation is incompletely understood. Here we show that histone H3.3 phosphorylation at serine 31 (H3.3S31) regulates disturbed-flow-induced endothelial inflammation by allowing rapid induction of FOS and FOSB, required for inflammatory gene expression. We identified protein kinase N1 (PKN1) as the kinase responsible for disturbed-flow-induced H3.3S31 phosphorylation. Disturbed flow activates PKN1 in an integrin α5β1-dependent manner and induces its translocation into the nucleus, and PKN1 is also involved in the phosphorylation of the AP-1 transcription factor JUN. Mice with endothelium-specific PKN1 loss or endothelial expression of S31 phosphorylation-deficient H.3.3 mutants show reduced endothelial inflammation and disturbed-flow-induced vascular remodeling in vitro and in vivo. Together, we identified a pathway whereby disturbed flow through PKN1-mediated histone phosphorylation and FOS/FOSB induction promotes inflammatory gene expression and vascular inflammation.
The impact of neuroscience education therapy, behavioral economics, and digital navigators on patient migraine treatment adherence to a mobile health application: a prospective pilot randomized controlled trial
Authors: Minen Mia T. , Waire Erin K. , Torous John , Fishman Jessica , Lipton Richard B. , Powers Scott W. 
Published: January 2025

Abstract
Mobile health (mHealth) tools can be used to deliver nonpharmacologic therapies to patients with migraine. However, mHealth studies often report poor treatment adherence. Neuroscience Education Therapy (NET), behavioral economics, and Digital Navigators have the potential to increase treatment adherence and thereby improve remote migraine self-management. We conducted a 6-month prospective pilot randomized controlled trial testing if a multi-component package of behavioral interventions increased treatment adherence among patients using one of two different mHealth migraine self-management programs (low-intensity program consisting only of a headache diary versus high-intensity program consisting of a headache diary and behavioral exercises). Our outcomes were the number of diary entries and behavioral exercises completed/week captured via back-end analytics of the mHealth application. We also compared our adherence data at 90-days (a secondary endpoint to assess the durability of the effect) with adherence data from similar published studies without the adherence-enhancing package. We enrolled 26 participants (n = 15 low intensity group, n = 11 high-intensity group). During the 6-week intervention period, we had a median of 7 headache diary entries/week in both groups and a median of 6 days/week of behavioral exercises in the high-intensity group. The rate of adherence with the adherence-enhancing package included was 2.9-8x higher compared to the median rates of the behavioral exercises to historical controls. With use of NET, behavioral economics, and digital navigators, participants achieved higher levels of adherence to both self-management programs compared to prior remote migraine self-management studies. Therefore, these tools may be beneficial to improving adherence to migraine self-management programs.
The Impact of Autistic Traits on Joint Attention in Young Children With Down Syndrome During Mother–Child and Father–Child Interactions
Authors: Sterling Audra , Lorang Emily , Reis Kelsey , Elmquist Marianne 
Published: January 2025

Purpose:
Joint attention predicts later language in Down syndrome (DS) and autism. The co-occurrence of autism in children with DS is 6%–19%, which is higher than in the general population. However, little is known about how co-occurring autism in DS impacts the development of joint attention. This study compared mother–child and father–child interactions in families of children with DS. Our purpose was to investigate differences in caregiver joint-attention bids and whether caregiver and child joint attention were associated with autistic traits and receptive language in children with DS.

Method:

Fifteen children with DS (
M
age
= 39.67 months) and their biological caregivers participated in the current study. We collected mother–child and father–child interactions in participant's homes. Using Wilcoxon signed-ranks tests, we examined if there were differences in mothers' and fathers' joint attention bids and if children responded differently to their bids. We used Spearman correlations to examine the associations between child autistic traits, receptive language, and caregiver and child joint attention.

Results:
We found that mothers initiated more joint-attention bids than fathers but did not find differences in child responsiveness or initiations based on communication partner. Mothers used more bids when children had more autistic traits. Child autistic traits were negatively correlated with child responsiveness to father joint-attention bids. Children with more autistic traits produced fewer joint-attention bids with both caregivers.

Conclusions:
Findings suggest mothers and fathers may use differing approaches to support their child's language development. Regardless of communication partner, children with more autistic traits engaged in fewer instances of joint attention.
North American Pilot of TBIconneCT: A Social Communication Intervention via Telehealth for Individuals With Traumatic Brain Injury and Their Conversation Partners
Authors: Hall Alyssa , Hoepner Jerry K. , Rietdijk Rachael , Togher Leanne 
Published: January 2025

Purpose:
The purpose of this pilot investigation was to identify formative feedback to guide the development of a North American version of the TBIconneCT program. A secondary purpose was to examine the feasibility of delivering the intervention by graduate students.

Method:
Two cohorts of individuals with chronic brain injuries and their communication partners were recruited for a 10-week, modified TBIconneCT program delivered by graduate student clinicians via telehealth. Eight dyads were recruited for the first cohort, but only four dyads completed the investigation. Ten dyads participated in the second cohort, but only seven dyads completed the investigation. Along with pre and post self-reported measures of communication and participation, participants completed an interview about their experiences. Interviews were transcribed and qualitatively coded using reflexive thematic analysis.

Results:
Participants from both cohorts improved in all pre- and postmeasures of communication and participation; however, gains were modest across the cohorts. Qualitative analyses were conducted separately by cohort, as results from the first cohort informed modifications that were implemented in the second cohort, primarily to address Australian English dialects. Across both contexts, overarching constructs included “participant perspectives regarding outcomes,” “assessments of the effectiveness of specific portions of the program,” and “suggestions for improvement.”

Conclusions:
The modified TBIconneCT program (North American pilot version) produced modest gains in measures of social communication, participation, and quality of life. Qualitative analyses provided insights into the strengths and weaknesses of the modified program, along with suggestions for refinement of the pilot version.
Re‐identification of patterned animals by multi‐image feature aggregation and geometric similarity
Authors: Nepovinnykh Ekaterina , Immonen Veikka , Eerola Tuomas , Stewart Charles V. , Kälviäinen Heikki 
Published: January 2025

AbstractImage‐based re‐identification of animal individuals allows gathering of information such as population size and migration patterns of the animals over time. This, together with large image volumes collected using camera traps and crowdsourcing, opens novel possibilities to study animal populations. For many species, the re‐identification can be done by analysing the permanent fur, feather, or skin patterns that are unique to each individual. In this paper, the authors study pattern feature aggregation based re‐identification and consider two ways of improving accuracy: (1) aggregating pattern image features over multiple images and (2) combining the pattern appearance similarity obtained by feature aggregation and geometric pattern similarity. Aggregation over multiple database images of the same individual allows to obtain more comprehensive and robust descriptors while reducing the computation time. On the other hand, combining the two similarity measures allows to efficiently utilise both the local and global pattern features, providing a general re‐identification approach that can be applied to a wide variety of different pattern types. In the experimental part of the work, the authors demonstrate that the proposed method achieves promising re‐identification accuracies for Saimaa ringed seals and whale sharks without species‐specific training or fine‐tuning.
The Significance of Information Quality for the Secondary Use of the Information in the National Health Care Quality Registers in Finland
Authors: Frondelius Anna , Kinnunen Ulla-Mari , Jormanainen Vesa 
Published: January 2025

Abstract
Background The aim of the national health care quality registers is to monitor, assess, and improve the quality of care. The information utilized in quality registers must be of high quality to ensure that the information produced by the registers is reliable and useful. In Finland, one of the key sources of information for the quality registers is the national Kanta services.
Objectives The objective of the study was to increase understanding of the significance of information quality for the secondary use of the information in the national health care quality registers and to provide information on whether the information quality of the national Kanta services supports the information needs of the national quality registers, and how information quality should be developed.
Methods The research data were collected by interviewing six experts responsible for national health care quality registers, and it was analyzed using theory-driven qualitative content analysis based on the DeLone and McLean model.
Results Based on the results, the relevance of the information in the Kanta services met the information needs of the national quality registers. However, due to the limited amount of structured information and deficiencies in the completeness of the information, relevant information could not be fully utilized. Deficiencies in information quality posed challenges in information retrieval and hindered drawing conclusions in reporting. Challenges in information quality did not diminish the intention to use the information when information was considered relevant. Solutions to improve information quality included structuring, development of documentation practices, patient information systems and quality assurance, as well as collaboration among stakeholders.
Conclusion The Kanta services' information is relevant for the national health care quality registers, but developing the quality of the information, especially in terms of structures and completeness, is the key to fully enabling the secondary use of this information.
Effectiveness of Basic Life Support Training Program on Knowledge, Attitude, and Self-Efficacy in Management of Drowning Among Adults Living in Coastal Areas of Mangaluru
Authors: Puthiyapurayil Riyaz M. , Chacko Leena K. , Naik Savitha 
Published: January 2025

Abstract
Introduction Drowning is a major, but often neglected, public health problem in India. About 97% of all deaths from drowning occur in low- and middle-income countries. Drowning is a preventable morbidity and mortality worldwide. Early use of basic life support (BLS) by a rescuer on site is crucial for the survival of victims of drowning.
Aim This article aims to find out the effectiveness of BLS training program on knowledge, attitude, and self-efficacy in the management of drowning.
Materials and Methods A preexperimental, one-group pretest, posttest study design was adopted to study 91 purposively selected subjects who met the selection criteria. The sample size was estimated using a research article by Joseph et al. The data were collected by using valid and reliable tools: 25-item knowledge questionnaire (r = 0.846), 15-item attitude scale (r = 0.867), and 12-item self-efficacy scale (r = 0.928). Ethical approval and informed consent obtained. After obtaining baseline data, pretest was conducted using the said tools and BLS training in the management of drowning was provided. Posttest assessment of knowledge, attitude, and self-efficacy was done 7 days after intervention.
Results More than three-fourths (80.2%) had inadequate knowledge during pretest, whereas in posttest half (49.5%) had adequate level of knowledge, with mean and standard deviation of 11.18 ± 3.82 in pretest and 18.21 ± 3.08 in posttest. Regarding attitude, more than half (63.7%) had neutral attitude during pretest and three-fourths (73.6%) had positive attitude in posttest with mean and standard deviation of 57.38 ± 6.44 in pretest and 64.87 ± 5.10 in posttest. A poor level of self-efficacy was reported among 58.2% in pretest, whereas 59.3% had fair level of self-efficacy in posttest. Mean and standard deviation was found to be 33.48 ± 7.73 in pretest and 46.25 ± 4.35 in posttest. There was a significant difference in the pretest and posttest scores of knowledge, attitude, and self-efficacy toward BLS at p < 0.05, indicating that BLS training is effective. The Karl Pearson correlation coefficient test showed a significant correlation between knowledge–attitude (r = 0.628, p < 0.001), knowledge–self-efficacy (r = 0.820, p < 0.001), and attitude–self efficacy (r = 0.616, p < 0.001).
Conclusion This study concluded that the BLS training program is effective on knowledge, attitude, and self-efficacy in the management of drowning
Percutaneous Cecostomy Catheters
Authors: Akinduro Oluwanifemi G. , Jacobs Adam P. , Gunn Andrew J. 
Published: January 2025

AbstractPercutaneous cecostomy catheters can be placed in the setting of either fecal incontinence or large bowel obstruction. While there are several etiologies for these disorders, the purpose of the cecostomy catheter is to provide ease of access for antegrade enemas in patients with fecal incontinence or relieve pain and discomfort in patients with a large bowel obstruction. Image-guided, percutaneous catheter placement into the cecum fits easily into the skillset of the interventional radiologist. Even though the literature consists of mostly single-center, retrospective case series, the procedure shows high rates of technical success, outstanding clinical outcomes, excellent patient satisfaction scores, and low rates of major adverse events. The purpose of this article is to review indications for cecostomy catheter placement, outline preprocedural patient evaluation, describe intraprocedural steps of catheter placement, detail postprocedural follow-up, and review both technical and clinical outcomes of cecostomy catheter placement.