bluuebunny/crossref_metadata_2025_split huggingface dataset:
Black seeds (Nigella sativa) for the management of Dengue viral disease: POM analyses for the identification of new antiviral pharmacophore sites
Authors: Maideen Naina Mohamed Pakkir , Hadda Taibi Ben , Almalki Faisal A. , Laarousi Hamid , Soliman Sameh S.M. , Kawsar Sarkar M.A. 
Published: July 2023

Abstract

The number of Dengue virus (DENV) infection cases has increased dramatically over the past two decades with an estimate of 3.9 billion cases across the globe are potentially at risk. Patients with a DENV infection are managed symptomatically and by supportive care since there is no approved antiviral drug yet for its management. On the other hand,Nigella sativahas been highlighted as a potential antiviral particularly against DENV. Hence, the anti-DENV potential ofN. sativais analyzed in this review using major databases including Medline/PMC/PubMed, Scopus, EBSCO, EMBASE, Google Scholar, and Science Direct. Moreover, the Petra/Osiris/Molinspiration (POM) bioinformatics platform-2019 was used to analyze a series of compounds (1-15) identified inN. sativa(the Black seeds) to identify those with promising antiviral pharmacophore sites. Preliminary research showed the potential ofN. sativain the control ofAedes aegyptimosquitoes and the enhancement of platelet counts. Besides, several clinical, animal,in vitroandin vivostudies have demonstrated the antiviral, immunomodulatory and antiinflammatory properties ofN. sativa. Furthermore, calculation of the physico-chemical properties ofN. sativacompounds using POM analyses indicated that dithymoquinone possesses a potential antiviral activity with two (O, O’) pharmacophore sites. As a result,N. sativacan be employed as an adjuvant/ supportive therapy in the management of DENV infection in the early stages of the illness. Furthermore,N. sativacan be a source of new lead anti-DENV drug.
Regionalization methods for PUB: a comprehensive review of progress after the PUB decade
Authors: Yang Xue , Li Fengnian , Qi Wenyan , Zhang Mengyuan , Yu Chengxi , Xu Chong-Yu 
Published: July 2023

Abstract
This paper presents an updated review of model-dependent regionalization methods in hydrology since the PUB decade, incorporating new regions and methodological advancements. Two categories of regionalization methods are discussed: distance-based and regression-based, with various modification approaches. Several factors affecting the accuracy of regionalization performance are identified, including hydrological models, climate characteristics, data availability, and regionalization techniques. The review concludes that distance-based regionalization methods with an output averaging option from multiple donor catchments are the most statistically reliable, and a threshold of 0.5–0.8 for donor selection is optimal for performance. The parsimonious hydrological model is also recommended, particularly in data-limited contexts. Other insights include the effectiveness of the ensemble concept and limited impact of prior classification. Additionally, it is found that the general performance difference between climatic classes is larger than between methods, and regression-based methods may have large uncertainties in tropical regions. Overall, this study provides practical guidance for improving regionalization studies and advancing the field of hydrology.
Contemporary Trends in Active and Intelligent Polymer Nanocomposite
based Food Packaging Systems for Food Safety and Sustainability in the
Modern Aeon
Authors: Pawar Jayant Rajaram , Phatak Rohan Sharadanand , Qureshi Nilam Mehmood. , Singh Athoiba Elangbam , Shinde Manish Dipakrao , Amalnerkar Dinesh Pundalik , Doh Jaehyeok 
Published: July 2023

Abstract:
The demand for innovative solutions has arisen from the inevitability of improved
packaging systems to protect processed food from various factors that cause spoilage. Traditional
food packaging materials have limitations in fulfilling all the requirements of consumers, such as
being inert, cheap, lightweight, easily degradable, reusable, and resistant to physical abuse. Nanofillers
incorporated in the polymer matrix can provide potential solutions to these challenges. This
review paper deliberates the use of nanofillers in a polymer matrix to develop an active and intelligent
polymer nanocomposites-based processed food packaging system. The present review article
focuses on the properties of nanofillers and their potential benefits when incorporated into the
polymer matrix. It also examines the challenges associated with developing such packaging systems
and explores the ways to address them. It highlights the potential of nanofiller-based polymer
nanocomposites in developing a novel food packaging system that can improve the shelf-life
and quality of processed food. Such systems can protect food from dirt or dust, oxygen, light,
moisture, and food-spoiling microorganisms. Incorporating nanofillers can provide a viable solution
to these problems. Most importantly, this paper provides research insights into the potential
benefits of nanofillers-based polymer nanocomposites and their applications in the food packaging
industry. The verdicts of this review will be of interest to the food packaging industry, entrepreneurs
and researchers interested in developing sustainable and innovative packaging systems.
Physician and Practice Characteristics Influencing Telemedicine Uptake Among Frontline Clinicians in the Early COVID-19 Pandemic Response: National Survey Study (Preprint)
Authors: Hamline Michelle Y , Xing Guibo , Kravitz Richard L , Miller Marykate , Melnikow Joy 
Published: July 2023

BACKGROUND

Telemedicine expanded rapidly during the COVID-19 pandemic, as key policy changes, financial support, and pandemic fears tipped the balance toward internet-based care. Despite this increased support and benefits to patients and clinicians, telemedicine uptake was variable across clinicians and practices. Little is known regarding physician and institutional characteristics underlying this variability.

OBJECTIVE

This study aimed to evaluate factors influencing telemedicine uptake among frontline physicians in the early pandemic response.

METHODS

We surveyed a national stratified sample of frontline clinicians drawn from the American Medical Association Physician Professional Data in June or July 2020. The survey inquired about the first month and most recent month (June 2020) of pandemic telemedicine use; sample data included clinician gender, specialty, census region, and years in practice. Local pandemic conditions were estimated from county-level data on COVID-19 rates at the time of survey response. Data were analyzed in a weighted logistic regression, controlling for county-specific pandemic data, and weighted to account for survey data stratification and nonresponse.

RESULTS

Over the first 3-4 months of the pandemic, the proportion of physicians reporting use of telemedicine in &gt;30% of visits increased from 29.2% (70/239) to 35.7% (85/238). Relative to primary care, odds of substantial telemedicine use (&gt;30%) both during the first month of the pandemic and in June 2020 were increased among infectious disease and critical care physicians and decreased among hospitalists and emergency medicine physicians. At least minimal prepandemic telemedicine use (odds ratio [OR] 11.41, 95% CI 1.34-97.04) and a high 2-week moving average of local COVID-19 cases (OR 10.16, 95% CI 2.07-49.97) were also associated with substantial telemedicine use in June 2020. There were no significant differences according to clinician gender, census region, or years in practice.

CONCLUSIONS

Prepandemic telemedicine use, high local COVID-19 case counts, and clinician specialty were associated with higher levels of substantial telemedicine use during the early pandemic response. These results suggest that telemedicine uptake in the face of the pandemic may have been heavily influenced by the level of perceived threat and the resources available for implementation. Such understanding has important implications for reducing burnout and preparation for future public health emergencies.
81th International Scientific Conference of the University of Latvia. Geodynamics and Geospatial Research. Conference Papers
Authors:   University of Latvia
Published: July 2023

The conference “Geodynamics and Geospatial Research” organized by the Institute of Geodesy and Geoinformatics of the University of Latvia addresses a wide range of scientific studies and is focused on the interdisciplinarity, versatility and possibilities of research in this wider context in the future to reach more significant discoveries, including business applications and innovations in solutions for commer-cial enterprises. The research presented at the conference is at different stages of its development and presents the achievements and the intended future. The publication is intended for researchers, students and research social partners as a source of current information and an invitation to join and support these studies.
Pengaruh Latihan Variasi Kelincahan Terhadap Kemampuan Dribbling Pada Pemain SSB
Authors: Prayoga Novian Ade , Ali Muhammad , Yanto Anggel Hardi 
Published: July 2023

Tujuan penelitian ini untuk mengetahui pengaruh latihan variasi kelincahan terhadap kemampuan dribbling sepakbola pada pemain SSB Sidorukun Kabupaten Tebo Tahun 2022. Metode yang digunakan dalam penelitian ini menggunakan metode eksperimen. Populasi penelitian ini adalah seluruh pemain SSB Sidorukun Kabupaten Tebo Tahun 2022 yang berjumlah 70 anak. Penelitian ini menggunakan teknik purposive sampling dengan total sampel 15 pemain. Variabel penelitian ini yaitu latihan variasi kelincahan antara lain shuttle run, zig- zag run, three corner drill, 8 run. Metode pengumpulan data dilakukan menggunakan instrumen tes kemampuan dribbling. Desain yang digunakan dalam penelitian ini adalah one group pretest posttest design. Hasil analisis data menggunakan uji t diperoleh thitung lebih besar dari t tabel yaitu 13,20> 2,145 dengan taraf signifikan 5%. Dengan demikian dapat dijelaskan bahwa terdapat peningkatan yang signifikan antara data sebelum dan sesudah diberikan perlakuan. Peningkatan rata-rata terlihat nyata karena terjadi peningkatan sebesar 2,60 dari 21,87 menjadi 19,27. Jika digambarkan dalam bentuk persentase peningkatan tersebut sebesar 13,49%. kesimpulan penelitian adalah terdapat pengaruh yang signifikan antara latihan variasi kelincahan terhadap kemampuan dribbling sepakbola pada pemain SSB Sidorukun Kabupaten Tebo.
<strong>Trajectories of liver fibrosis and gene expression profiles in NAFLD associated with diabetes</strong>
Authors: Sako Saori , Takeshita Yumie , Takayama Hiroaki , Goto Hisanori , Nakano Yujiro , Ando Hitoshi , Tsujiguchi Hiromasa , Yamashita Tatsuya , Arai Kuniaki , Kaneko Shuichi , Nakamura Hiroyuki , Harada Kenichi , Honda Masao , Takamura Toshinari 
Published: July 2023

<p>Understanding the mechanisms linking steatosis to fibrosis is needed to establish a promising therapy against nonalcoholic fatty liver disease (NAFLD). This study aims to clarify clinical features and hepatic gene expression signatures that predict and contribute to liver fibrosis development during the long-term real-world histological course of NAFLD subjects with and without diabetes. A pathologist scored 342 serial liver biopsy samples from 118 subjects clinically diagnosed with NAFLD during a 3.8 years (SD 3.45, maximum 15 years) course of clinical treatment (UMIN; Clinical Trials Registry, no. UMIN000035231). At the initial biopsy, 26 subjects had simple fatty liver, and 92 had nonalcoholic steatohepatitis (NASH). In the trend analysis, the Fibrosis-4 index (P < 0.001) and its components at baseline predicted the future fibrosis progression. In the generalized linear mixed model, an increase in HbA1c, but not BMI, was significantly associated with fibrosis progression (0.17 [0.009–0.326]; P = 0.038) for NAFLD subjects with diabetes. In gene set enrichment analyses, the pathways involved in hepatocytes zone 3, central liver sinusoidal endothelial cell (LSEC), stellate cells, and plasma cells were coordinately altered in association with fibrosis progression and HbA1c elevation. Therefore, in NAFLD subjects with diabetes, HbA1c elevation is significantly associated with liver fibrosis progression, independent of weight gain, which may be a valuable therapeutic target to prevent the pathological progression of NASH. Gene expression profiles suggest that diabetes-induced hypoxia and oxidative stress injure LSEC injury in zone 3, which may mediate inflammation and stellate cell activation, leading to liver fibrosis. </p>
PERCEIVED CORRELATION BETWEEN COMMUNICATION STYLES AND INTERPERSONAL CONFLICT RESOLUTION AMONG INTERNATIONAL STUDENTS IN MALAYSIA
Authors: Mohammed Shamsuddeen , Nasidi Qaribu Yahaya , Muhammed Mahmud Umar , Muhammad Umar Musa , Hassan Isyaku 
Published: July 2023

Background and Purpose: A good and fulfilling relationship among individuals from distinct cultural backgrounds depends on effective communication. This research examined the perceived relationship between communication styles and interpersonal conflict resolution among international students in Malaysian universities.

Methodology: The study employed a cross-sectional survey in which self-developed structured questionnaires were used to gather data from a random sample of 324 international students in 15 higher institutions across Kuala Lumpur, Malaysia. The data were analyzed using multiple regression analysis.

Findings: The findings of this study revealed a significant positive relationship between communication styles and interpersonal conflict resolution among international students. Specifically, passive, passive-aggressive, and assertive communication styles have a significant positive relationship with conflict resolution. However, the aggressive communication style exerts an insignificant effect on conflict resolution with a t-value of 0.734 and a P-value of 0.463. Thus, the students generally believe this style does not help to resolve interpersonal conflict. These outcomes suggest the students’ readiness for cultivating a peaceful learning environment.

Contributions: This study provides relevant information that can help educational decision-makers to strengthen cross-cultural collaboration among international students in the Malaysian context. This valuable information can also facilitate successful academic, professional, and social cooperation.

Keywords: Cross-cultural relationship, interpersonal conflict resolution, communication styles, international students, Malaysia.

Cite as: Mohammed, S., Nasidi, Q. Y., Muhammed, M. U., Umar, M. M., & Hassan, I. (2023). Perceived correlation between communication styles and interpersonal conflict resolution among international students in Malaysia. Journal of Nusantara Studies, 8(2), 352-372. http://dx.doi.org/10.24200/jonus.vol8iss2pp352-372
THE CONSTRUCTION AND NEGOTIATION OF AGENTIVE IDENTITY: A CASE STUDY OF A MALAYSIAN STUDENT
Authors: Tun Nadia , Khairuddin Zurina 
Published: July 2023

Background and Purpose: The success of the government’s aspiration into developing holistic Malaysian students not only lies in what has been going in today’s classroom but also outside classroom in which the fundamental process of seeking for knowledge, skills and competencies. Holistic identity is not a construct that is inherited, nor does it remain constant but is developed and evolves from different academic encounters faced by the students. Thus, the present study investigated the construction and negotiation of a student’s identity from her interaction within academic settings in Malaysian Higher Education Institution (MHEI).

Methodology: The study employed qualitative research and linguistic ethnography approaches utilising case study as the research design. One (1) Malaysian student from a MHEI was chosen using purposive sampling technique. The data for the study were collected from classroom observations, interview and focus group discussion. The data were analysed using thematic analysis and identity in interaction framework analysis.

Findings: The participant of this study constructed and negotiated an agentive identity during the process of making conscious decisions in her academic experiences. Agentive identity could be seen emerged from her interactions and indexed from her behaviour and opinion during her academic encounters (inside and outside the classroom). The participant’s engagement behaviour portrayed could be interpreted as being agentive from the lens of the two principles in identity framework analysis namely; the emergence principle and the indexicality principle.

Contributions: Experiencing different educational contexts could help to shape Malaysian students to be balanced, academically and morally, as aspired by the Malaysia National Education Philosophy. Malaysian students are seen as the catalysts who would lead the country in the future. The findings of this study could also be used as a reference on how educational practices reflect on the production of individuals as manifested in the NEP. Examining how students construct and negotiate their identities in a new or/and familiarised academic convention could enlighten the stakeholders such as the students themselves, lecturers, tutors, parents, and ministry to be more flexible, allowing students to be empowered within appropriate contexts.

Keywords: Malaysian students, students’ identity, higher education, student agency, agentive identity

Cite as: Nadia, T., & Zurina, K. (2023). The construction and negotiation of agentive identity: A case study of a Malaysian student. Journal of Nusantara Studies, 8(2), 373-394. http://dx.doi.org/10.24200/jonus.vol8iss2pp373-394
Equine bronchial epithelial cells are susceptible to cell entry with a SARS-CoV-2 pseudovirus but reveal low replication efficiency
Authors: Legere Rebecca M. , Allegro Angelica R. , Affram Yvonne , Silveira Bibiana Petri da , Fridley Jennifer L. , Wells Kelsey M. , Oezguen Numan , Burghardt Robert C. , Wright Gus A. , Pollet Jeroen , Bordin Angela I. , Figueiredo Paul de , Leibowitz Julian L. , Cohen Noah D. 
Published: July 2023

Abstract

OBJECTIVE
To examine the susceptibility of cultured primary equine bronchial epithelial cells (EBECs) to a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pseudovirus relative to human bronchial epithelial cells (HBECs).

SAMPLE
Primary EBEC cultures established from healthy adult horses and commercially sourced human bronchial epithelial cells (HBECs) were used as a positive control.

METHODS
Angiotensin-converting enzyme 2 (ACE2) expression by EBECs was demonstrated using immunofluorescence, western immunoblot, and flow cytometry. EBECs were transduced with a lentivirus pseudotyped with the SARS-CoV-2 spike protein that binds to ACE2 and expresses the enhanced green fluorescent protein (eGFP) as a reporter. Cells were transduced with the pseudovirus at a multiplicity of infection of 0.1 for 6 hours, washed, and maintained in media for 96 hours. After 96 hours, eGFP expression in EBECs was assessed by fluorescence microscopy of cell cultures and quantitative PCR.

RESULTS
ACE2 expression in EBECs detected by immunofluorescence, western immunoblotting, and flow cytometry was lower in EBECs than in HBECs. After 96 hours, eGFP expression in EBECs was demonstrated by fluorescence microscopy, and mean ΔCt values from quantitative PCR were significantly (P < .0001) higher in EBECs (8.78) than HBECs (3.24) indicating lower infectivity in EBECs.

CLINICAL RELEVANCE
Equine respiratory tract cells were susceptible to cell entry with a SARS-CoV-2 pseudovirus. Lower replication efficiency in EBECs suggests that horses are unlikely to be an important zoonotic host of SARS-CoV-2, but viral mutations could render some strains more infective to horses. Serological and virological monitoring of horses in contact with persons shedding SARS-CoV-2 is warranted.
Remarks on bipolar cubic fuzzy graphs and its chemical applications
Authors: Lu Juanjuan , Zhu Linli , Gao Wei 
Published: July 2023

Abstract
In theoretical chemistry, fuzzy molecular graphs can be used to model chemical molecular structures with uncertainty information, where the vertex membership function and edge membership function describe the uncertainty of atoms and chemical bonds respectively. This paper studies chemical topological index of bipolar cubic fuzzy graphs. The new concepts and theorems are given in terms of graph theory and fuzzy set theory approaches and several theoretical conclusions on bipolar Wiener index of bipolar cubic fuzzy graphs are determined. Furthermore, we apply it in chemical science and calculate the bipolar Wiener index of dimethyltryptamine and hallucinogen which are modelled by bipolar cubic fuzzy graphs.
Multigene Sequence-Based and Phenotypic Characterization Reveals the Occurrence of a Novel Entomopathogenic Nematode Species, Steinernema anantnagense n. sp.
Authors: Bhat Aashaq Hussain , Machado Ricardo A. R. , Abolafia Joaquín , Askary Tarique Hassan , Půža Vladimír , Ruiz-Cuenca Alba Nazaret , Rana Aasha , Sayed Samy , Al-Shuraym Laila A. 
Published: July 2023

Abstract
Three entomopathogenic nematode populations were isolated from agricultural fields in the Anantnag district of Jammu and Kashmir (India). Sequences of multiple gene regions and phenotypic features show that they are conspecific and represent a novel species. Molecular and morphological features provided evidence for placing the new species into the “Kushidai” clade. Within this clade, analysis of sequence data of the internal transcribed spacer (ITS) gene, the D2D3 region of the 28S rRNA gene, the mitochondrial cytochrome oxidase I (mtCOI) gene, and the mitochondrial 12S (mt12S) gene depicted the novel species as a distinctive entity closely related to Steinernema akhursti, S. kushidai, and S. populi. Phylogenetic analyses also show that the new species is a sister species to S. akhursti, and these two species are closely related to S. kushidai and S. populi. Additionally, the new species does not mate or produce fertile progeny with any of the closely related species, reinforcing its uniqueness from a biological species concept standpoint. The new species is further characterized by the third-stage infective juveniles with almost straight bodies (0.7–0.8 mm length), poorly developed stoma and pharynx, and conoid-elongate tail (49–66 µm) with hyaline posterior part. Adult females are characterized by short and conoid tails bearing a short mucron in the first generation and long conoid tails with thin mucron in the second generation. Adult males have ventrally curved spicules in both generations. Moreover, the first-generation male has rounded manubrium, fusiform gubernaculum, conoid and slightly ventrally curved tails with minute mucron, and the second generation has rhomboid manubrium anteriorly ventrad bent, and tails with long and robust mucron. The morphological, morphometrical, molecular, and phylogenetic analyses support the new species status of this nematode, which is hereby described as Steinernema anantnagense n. sp. The bacterial symbiont associated with S. anantnagense n. sp. represents a novel species, closely related to Xenorhabdus japonica. These findings shed light on the diversity of entomopathogenic nematodes and their symbiotic bacteria, providing valuable information for future studies in this field.