bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nonlocal state-space strain gradient wave propagation of magneto thermo piezoelectric functionally graded nanobeam
Authors: Selvamani Rajendran , Loganathan Rubine , Dimitri Rossana , Tornabene Francesco 
Published: April 2023

Abstract
In this work, the state -space nonlocal strain gradient theory is used for the vibration analysis of magneto thermo piezoelectric functionally graded material (FGM) nanobeam. An analysis of FGM constituent properties is stated by using the power law relations. The refined higher order beam theory and Hamilton’s principle have been used to obtain the motion equations. Besides, the governing equations of the magneto thermo piezoelectric nanobeam are extracted by developed nonlocal state-space theory. And to solve the wave propagation problems, the analytical wave dispersion method is used. The effect of magnetic potential, temperature gradient, and electric voltage in variant parameters are presented in graph.
Innovation Ambidexterity and Firm Performance: The Moderating Effects of Contextual Factors
Authors: Fragoso Rui , Scazziota Vanessa , Guerrazzi Luiz , Quaresma Rui , Casas Novas Jorge 
Published: April 2023

Abstract
The purpose of this paper is to assess the moderating effects of motivating and contextual factors on the relationship of innovation ambidexterity and firm performance. A theoretical framework was developed and tested using survey data from a sample of the Global University Entrepreneurial Spirit Students’ Survey (GUESSS). The results suggest a positive effect of ambidexterity on firm performance, which is positively moderated by motivating factors, the number of co-owners and normative and cognitive institutions, such as power distance and university environment and program learning, respectively. The study provides important insights for policymakers to promote entrepreneurial education and clues for future research, as well as extends existing theory by offering insights on the moderator effects of individual and contextual factors on the relationship between ambidexterity and firm performance, assuming the benefits of the synergic effects of exploration and exploitation.
Performance evaluation simulation of the optical splitters integrated with unidirectional fiber elements
Authors: Rashed Ahmed Nabih Zaki , Reddy Mittamidi Madhusudhan , Nagendram Sanam , Anwer Twana Mohammed Kak , Ahammad Shaik Hasane , Kumar Munuswamy Siva , Hossain Md. Amzad , Mousad Aya 
Published: April 2023

Abstract
This study has clarified the performance evaluation simulation of the optical splitters integrated with unidirectional fiber elements. The simulative performance evaluation of electrostatic, thermal, and piezoelectric actuation based micro electro mechanical systems. The force against the displacement based electrostatic and elastic forces for parallel plate actuator is simulated by MEMSover simulation software. The voltage with angular displacement for a torsion bar actuator is clarified. Besides the lateral displacement against voltage for a comb drive actuator is reported. The dependence of the film thickness on the deflection of a bimetallic cantilever, the dependence of passive beam length on deflection of a bimorph actuator and the transient response of a bent beam actuator are demonstrated. Moreover the piezoelectric actuator force against applied voltage and the piezoelectric actuator displacement against applied voltage variations are reported.
Immediate effects of atrazine application on soil organic carbon and selected macronutrients and amelioration by sawdust biochar pretreatment
Authors: Oyeyiola Yetunde Bunmi , Opeolu Beatrice Olutoyin 
Published: April 2023

Abstract
Increasing use of herbicides has contributed immensely to current soil and water degradation in the tropics. Published works on effects of herbicides on soil organic carbon (SOC) – a major indicator for soil health and macronutrients and their enhancement by biochar are scarce for soils in Africa despite heavy herbicide applications every cropping season. This incubation trial evaluated immediate effects of atrazine application on SOC and selected soil macronutrients. The potential of sawdust (SD) biochar to mitigate associated SOC and macronutrients depletion was also assessed. A total of 950 g soil was placed in each leaching column (20 cm length and 7 cm diameter). The experiment was a factorial combination of four SD biochar types: SD + poultry manure (PM) pyrolyzed at 350 °C, SD-PM at 350 °C, SD + PM at 450 °C and SD-PM at 450 °C applied at two rates of 5 and 10 t/ha equivalent to 2.38 and 4.76 g/950 g soil, respectively. Atrazine alone and absolute control (AC) that received neither biochar nor atrazine were included for comparison. The treatments were replicated thrice in completely randomized design. Appropriate biochar was applied within 5 cm soil depth, moistened to field capacity, and left to equilibrate for 2 weeks. Thereafter, 20 mL atrazine solution was applied at 2.5 kg a.i/ha (achieved through 6.75 g atrazine powder/l of distilled water). Basal NPK 15:15:15 fertilizer mixed with urea at 0.1 and 0.03 g/900 g soil, respectively, was applied to mimic farmers’ practice on atrazine treated fields. Maize seeds were thereafter sown in the treated soils and nurtured for 2 weeks. Data taken on soil pH, SOC, exchangeable bases, available phosphorus, and dry biomass weight (DBW) of maize seedlings at the expiration of the trial were subjected to two-way analysis of variance using Genstat Statistical Package with means separated using LSD at 5% probability level. There were significant reductions in soil pH (5.8%), SOC (31%), and Ex. Ca (27%) in atrazine alone soil compared to AC. Contrarily, similar atrazine treated soil pretreated with SD biochar had increased soil pH, SOC, exchangeable Ca, available P, and DBW by 5.6 (in SD + PM@450 °C), 73.6 (SD-PM@450 °C), 84 (SD + PM@450 °C), 2,338.4 (SD + PM@450 °C), and 154.8% (SD + PM@350 °C), respectively, dominantly at 10 t/ha compared to AC. Sole atrazine treated soil was, however, higher in soil available P (23.8 mg/kg) and TDBW (0.56 g) against 5.42 mg/kg and 0.42 g from AC, respectively. Biochar pH and organic carbon were the most influential biochar properties contributing significantly to SOC sequestration and macronutrient enrichment in the atrazine treated soil. Pretreatment of soils with sawdust biochar prior to atrazine application is, therefore, recommended for mitigating associated organic carbon and macronutrient depletion in the soils for enhanced maize production.
„Első a kötelesség”
Authors: Dezső Krisztina 
Published: April 2023

Beck Soma 1924-ben már nemzetközileg is elismert tudósként érkezett Pécsre, hogy megszervezze a városba költöző Erzsébet Tudományegyetem bőrgyógyászati klinikáját. A mostoha körülmények ellenére pár év alatt egy jól működő klinikát állított fel, ahol mind a bőrbetegségekkel, mind a nemi betegségekkel küzdő pácienseket fogadni tudták. A gyógyító tevekénység mellett az egyetemi oktatásban és kutatásokban is jelentős munkát végzett a professzor. A klinikán értékes mulázsgyűjteményt készíttetett, melyek az oktatásban használtak, szakkönyvtárának átengedésével a klinika könyvtárának alapját vetette meg. Tudományos munkássága a rákkutatásra, a csecsemőkori bőrbetegségekre, a háborús fagyási sérülések kezelésére terjedt ki. Legjelentősebb műve a Krompecher Ödönnel közösen írt Die feine Architektur der primären Hautcarcinome című kötet, amelyben a bőr rákos daganatait vizsgálták. Elsőként írta le az erythema myoticum infantilénak nevezett csecsemőkori bőrbetegséget. Emellett két tojásolajalapú kenőcsöt is kifejlesztett.
LINC00493‐encoded microprotein SMIM26 exerts anti‐metastatic activity in renal cell carcinoma
Authors: Meng Kun , Lu Shaohua , Li Yu‐Ying , Hu Li‐Ling , Zhang Jing , Cao Yun , Wang Yang , Zhang Chris Zhiyi , He Qing‐Yu 
Published: April 2023

AbstractHuman microproteins encoded by long non‐coding RNAs (lncRNA) have been increasingly discovered, however, complete functional characterization of these emerging proteins is scattered. Here, we show that LINC00493‐encoded SMIM26, an understudied microprotein localized in mitochondria, is tendentiously downregulated in clear cell renal cell carcinoma (ccRCC) and correlated with poor overall survival. LINC00493 is recognized by RNA‐binding protein PABPC4 and transferred to ribosomes for translation of a 95‐amino‐acid protein SMIM26. SMIM26, but not LINC00493, suppresses ccRCC growth and metastatic lung colonization by interacting with acylglycerol kinase (AGK) and glutathione transport regulator SLC25A11 via its N‐terminus. This interaction increases the mitochondrial localization of AGK and subsequently inhibits AGK‐mediated AKT phosphorylation. Moreover, the formation of the SMIM26‐AGK‐SCL25A11 complex maintains mitochondrial glutathione import and respiratory efficiency, which is abrogated by AGK overexpression or SLC25A11 knockdown. This study functionally characterizes the LINC00493‐encoded microprotein SMIM26 and establishes its anti‐metastatic role in ccRCC, and therefore illuminates the importance of hidden proteins in human cancers.
STAT5bis a key effector ofNRG‐1/ERBB4‐mediated myocardial growth
Authors: Vaparanta Katri , Jokilammi Anne , Paatero Ilkka , Merilahti Johannes A , Heliste Juho , Hemanthakumar Karthik Amudhala , Kivelä Riikka , Alitalo Kari , Taimen Pekka , Elenius Klaus 
Published: April 2023

AbstractThe growth factor Neuregulin‐1 (NRG‐1) regulates myocardial growth and is currently under clinical investigation as a treatment for heart failure. Here, we demonstrate in severalin vitroandin vivomodels that STAT5b mediates NRG‐1/EBBB4‐stimulated cardiomyocyte growth. Genetic and chemical disruption of the NRG‐1/ERBB4 pathway reduces STAT5b activation and transcription of STAT5b target genesIgf1,Myc, andCdkn1ain murine cardiomyocytes. Loss ofStat5balso ablates NRG‐1‐induced cardiomyocyte hypertrophy. Dynamin‐2 is shown to control the cell surface localization of ERBB4 and chemical inhibition of Dynamin‐2 downregulates STAT5b activation and cardiomyocyte hypertrophy. In zebrafish embryos, Stat5 is activated during NRG‐1‐induced hyperplastic myocardial growth, and chemical inhibition of the Nrg‐1/Erbb4 pathway or Dynamin‐2 leads to loss of myocardial growth and Stat5 activation. Moreover, CRISPR/Cas9‐mediated knockdown ofstat5bresults in reduced myocardial growth and cardiac function. Finally, the NRG‐1/ERBB4/STAT5b signaling pathway is differentially regulated at mRNA and protein levels in the myocardium of patients with pathological cardiac hypertrophy as compared to control human subjects, consistent with a role of the NRG‐1/ERBB4/STAT5b pathway in myocardial growth.
Left atrial appendage exclusion using a stapler with thoracoscopic ablation of atrial fibrillation
Authors: Revishvili A. Sh. , Kadirova M. , Strebkova E. D. , Malishenko E. S. , Novikov M. A. , Yalova E. V. , Babadjanova K. A. , Bandurko K. E. , Karmazanovsky G. G. 
Published: April 2023

Highlights. Stroke prevention in patients with atrial fibrillation is extremely important and difficult. Lifelong anticoagulant therapy is not always an effective way of preventing thrombosis in the left atrial appendage in this group of patients. In this regard, one of the most urgent problems of modern surgical arrhythmology and cardiac surgery is the search for new open and minimally invasive surgical methods of excluding the left atrial appendage from the blood flow.Aim. To investigate the safety and efficacy of using the left atrial appendage stapler for video-guided thoracoscopic ablation (TSA) of non-valvular atrial fibrillation (AF).Methods. The retrospective, single-center study included 100 patients with non-valvular AF who underwent video-guided thoracoscopic ablation of AF with single-stage left atrial appendage exclusion using an Endo GIA stapler (Medtronic, Minneapolis, Minnesota, USA).Results. The mean age of the patients was 56,2±8,8 years, the majority of the patients (73 patients, 73%) were male. Patients with persistent 50 (50%) AF and longstanding AF 50 (50%) were included in the study. The duration of atrial fibrillation was 4 (1,7–7) years. The median CHA2DS2-VASc and HAS-BLED scores were 2 (1–1,5) and 1 (0-1), respectively. The mean anticoagulation therapy-to-ablation time was 4,2±1,9 years. Thirty-eight (38%) patients were prescribed warfarin preoperatively. The completeness of left atrial appendage (LAA) exclusion was confirmed by intraoperative transesophageal echocardiography. The average length of the staple lines was 48 (35–75). A single left atrial appendage exclusion was performed using a 60 mm staples. In 12 (12%) patients, stapler exclusions were performed using two 45 mm staples due to insufficient staple length. None of the patients had ruptures, punctures along the staple lines or rupture of the surrounding epicardial tissue. Anticoagulant therapy was discontinued 6 months after TSA in 70 (70%) patients with sustained sinus rhythm observed on 24-h Holter Monitoring, satisfactory CHA2DS2-VASc scores and after confirmation of absence of left atrial thrombus by transesophageal echocardiography and contrast-enhanced MSCT. No strokes were reported within 1,2±0,7 years after discontinuing anticoagulation therapy.Conclusion. Exclusion of LAA using a stapler for TSA is a highly effective and safe technique for patients with non-valvular atrial fibrillation compared to alternative methods of excluding the LAA from the systemic blood flow.
Ultrasound and magnetic resonance of extrinsic stenosis and hypoplasia of internal jugular veins
Authors: Semenov S. E. , Bondarchuk D. V. , Malkov I. N. , Shatokhina M. G. 
Published: April 2023

Highlights. Ultrasound and MR venography of internal jugular veins in case of unilateral cerebellar hypoplasia or extrinsic stenosis enables noninvasively and without contrast agents differentiation of these conditions due to local and region-specific indicators, including the area and velocity of blood flow, arterial-venous balance, visualization of low blood flow, compression factor, and the overall clinical picture of venous network of the neck remodeling and the development of collateral circulation.Aim. To compare the visual and hemodynamic characteristics of ultrasound and magnetic resonance venography of extrinsic stenosis and hypoplasia of internal jugular veins (IJV).Methods. Ultrasound and magnetic resonance (MR) venography were performed in 47 patients with extrinsic stenosis and 23 patients with hypoplasia of one of internal jugular veins, and in the control group (30 patients).Results. In case of obvious vein compression and deformation and local stenosis (65% on average), there is a decrease in the vein cross-sectional area by 2 times compared with the contralateral vein, the blood flow velocity in the stenotic vein in acute cases increases (on average, up to 45 cm/s), and in chronic cases it significantly (p = 0.00001) decreases (to 13 cm/s on average). The criteria for hypoplasia are the small caliber of the vein (on average 0.22 cm², within the range of 0.13–0.46 cm²) throughout its entire length - with the cross-sectional area not exceeding that of the common carotid artery, and the vein being 4 times smaller than IJV on contralateral side, as well as a significant (p = 0.0006) velocity increase on the contralateral side (on average 40.9±12.52 cm/s) with normal velocity in the hypoplastic vein. Ultrasound assessment of the arterial-venous balance (AVB) makes it possible to evaluate the contribution of each IJV to the outflow of venous blood from the brain separately. From the hypoplastic side it was only 11.01±6.72%, and from the stenotic side it was 18.22±17 42% on average, which is significantly (p = 0.000001) below the norm, but does not allow us to differentiate these conditions. The total AVB for IJVs on both sides was within normal values (65–85%), and the absence of a pronounced expansion of the vertebral veins during MR venography confirms their insignificant role in the compensatory mechanisms of ensuring adequate outflow of venous blood from the brain in cases of unilateral hypoplasia and extrinsic stenosis of IJV.Conclusion. Ultrasound and MR venography of internal jugular veins in cases of unilateral hypoplasia or extrinsic stenosis enable noninvasively and without contrast agents differentiation of these conditions due to local and region-specific indicators, including the area and velocity of blood flow, arterial-venous balance, visualization of low blood flow, compression factor, and the overall clinical picture of venous network of the neck remodeling and the development of collateral circulation.
Features of the Development of the Health Care System in Megacity
Authors: Масленникова А.В. , Новопашин К.Г. 
Published: April 2023

Рассматривается современная организация системы здравоохранения в мегаполисах на примере г. Москвы. На основе официальной статистики, характеризующей развитие системы здравоохранения в Москве, исследован процесс внедрения цифровых технологий, определены достоинства и недостатки цифровизации системы управления и учреждений здравоохранения.
The article discusses the modern organization of the healthcare system in megacities using the example of the city of Moscow. On the basis of offi cial statistics characterizing the development of the healthcare system in the city of Moscow, the process of introducing digital technologies has been studied, the advantages and disadvantages of digitalization of the management system and healthcare institutions have been identified.
Legal Regulation of Medical Organizations’ Entrepreneurial Activity: Problems and Restrictions
Authors: Хрячков А.Д. 
Published: April 2023

Рассматриваются вопросы правового регулирования деятельности медицинских организаций. Проведен анализ действующего отечественного законодательства, уделено внимание рассмотрению ограничений, устанавливаемых для частных медицинских организаций. Выявлены основные проблемные аспекты в соответствующей сфере.
The article addresses the legal regulation of the activities of medical organizations. The analysis of the current domestic legislation is carried out, attention is paid to the consideration of restrictions imposed on private medical organizations. The article identifies the main problematic aspects in the legal regulation in this field.
Patterns of salivary gland lesions on fine needle aspiration cytology (FNAC)
Authors: Gupta Chhavi , Gupta Rajat 
Published: April 2023

A diverse range of inflammatory, cystic and neoplastic processes affect salivary glands.Fine needle aspiration cytology (FNAC) is a reliable tool for evaluation of salivary gland lesions. To analyse the cytomorphological features of salivary gland lesions and to assess the frequency of distribution of these lesions. It was an observational study conducted in the Department of Pathology, Govt. Medical College, Jammu. FNAC was performed on patients presenting with salivary gland swelling. May-Grunwald-Giemsa (MGG) and Papanicolaou (PAP) stained smears were examined under light microscope. The cytomorphological features were analysed and diagnosis was made. There were 65 cases which included 31 (47.7%) males and 34 (52.3%) females. The mean age of patients was 42.96 years. On microscopic examination, neoplastic lesions were 35 (53.8%) and non neoplastic lesions were 30 (46.2%). Pleomorphic adenoma was the most common benign neoplastic lesion and also was the most frequently diagnosed lesion in our study (21, 32.3%). Mucoepidermoid carcinoma cases were maximum among malignant lesions (4, 6.2%). Parotid gland was involved in majority of cases. FNAC is a simple, rapid, reliable tool for the evaluation of salivary gland lesions thereby helping clinicians in deciding the further management plan.
Aplikasi Penyalut Berbahan Tepung Lidah Buaya untuk Mempertahankan Mutu Bunga Edibel
Authors: Darmawati Emmy , Ayu Hakim Adinda Putri 
Published: April 2023

Edible flower is a flower that is safe for consumption both in fresh and processed form. In fresh form, edible flowers are used as garnishes or food decorations and a unique flavor enhancer. Kenikir (Cosmos sulphureus) is one of the edible flowers that are safe for consumption in fresh form. However, in fresh condition, flowers are easily damaged so that their market share is limited. Coating using aloe vera, which can hold moisture while having antimicrobial properties, is a method to maintain flower freshness. The purpose of the study was to examine the effect of aloe vera coating application to maintain the quality of kenikir as a fresh edible flower. The experimental design used was a two-factor completely randomized design with the first factor being the concentration of aloe vera flour (0.5% and 1%) and the second factor being spray frequency (1 application and 2 applications). Quality parameters measured during storage were respiration rate, weight loss, moisture content, and color. The results showed that the coating with the L2S2 formulation (1% aloe vera flour concentration with 2 applications) was the best treatment with a weight loss value of 7.3%, water content 82.57%, respiration rate 898.99 ml kg-1 hour-1, and has the highest brightness value. Based on these parameters, the L2S2 treatment could maintain the quality of kenikir as fresh edible flowers for up to 5 days compared to the control, which lasted 2 days at 10°C storage temperature.

Keywords: aloe vera powder, coat spraying, Cosmos sulphureus, edible flower, kenikir flower
Daya Saing Biji Pala Indonesia di Pasar Internasional
Authors: Samhina Lina , Nurmalina Rita , Tinaprilla Netti 
Published: April 2023

Indonesia is a nutmeg exporter with the highest export value during 2012‒2020. However, the growth of Indonesia's export value is lower than its competitors. Therefore, to maintain its position as a major exporter, it is important to know its competitiveness. This study aims to explain the competitiveness of Indonesian nutmeg in the world and in ten export destinations. In addition, this study was conducted to analyze the competitive position in the export destination market. The study uses secondary data from UN Comtrade. The data are Indonesian export values of whole and powdered nutmeg in the international market and in ten destination countries during 2012‒2020. The data were processed using revealed comparative advantage (RCA) and dynamic revealed comparative advantage (DRCA) analysis. The results showed that Indonesian whole and powdered nutmeg were competitive in the world market. However, the competitiveness is lower than nutmeg competitiveness of Sri Lanka. Indonesian nutmegs in ten destination markets are also competitive, with the highest competitiveness being in Italy and Germany. Nevertheless, the always positive growth of competitiveness from two products occurred in Japan, thus make Japan's competitive position in rising star during the period of 2018‒2020. Increasing the competitiveness of nutmeg can be done by increasing the export value of the product through regulations by the government regarding post-harvest handling so that there is only a small amount of aflatoxin. In addition, the government can more focus on increasing exports to Japan.

Keywords: competitiveness, dynamic revealed comparative advantage, revealed comparative advantage, nutmeg