bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of the accuracy of 9 intraocular lens power calculation formulas after SMILE in Chinese myopic eyes
Authors: Li Liangpin , Yuan Liyun , Yang Kun , Wu Yanan , Alafati Simayilijiang , Hua Xia , Wang Yan , Yuan Xiaoyong 
Published: June 2023

Abstract
As of 2021, over 2.8 million cases of small incision lenticule extraction (SMILE) procedures had been performed in China. However, there remains limited knowledge regarding the selection of intraocular lens (IOL) power calculation formulas for post-SMILE cataract patients. This study included 52 eyes of 26 myopic patients from northern China who underwent SMILE at Tianjin Eye Hospital from September 2022 to February 2023 and was designed to investigate the performance of multiple IOL calculation formulas in post-SMILE patients using a theoretical surgical model. We compared the postoperative results obtained from three artificial intelligence (AI)-based formulas and six conventional formulas provided by the American Society of Cataract and Refractive Surgery (ASCRS). These formulas were applied to calculate IOL power using both total keratometry (TK) and keratometry (K) values, and the results were compared to the preoperative results obtained from the Barrett Universal II (BUII) formula in SMILE cases. Among the evaluated formulas, the results obtained from Emmetropia Verifying Optical 2.0 Formula with TK (EVO-TK) (0.40 ± 0.29 D, range 0 to 1.23 D), Barrett True K with K (BTK-K, 0.41 ± 0.26 D, range 0.01 to 1.19 D), and Masket with K (Masket-K, 0.44 ± 0.33 D, range 0.02 to 1.39 D) demonstrated the closest proximity to BUII. Notably, the highest proportion of prediction errors within 0.5 D was observed with BTK-K (71.15%), EVO-TK (69.23%), and Masket-K (67.31%), with BTK-K showing a significantly higher proportion compared to Masket-K (p < 0.001). Our research indicates that in post-SMILE patients, EVO-TK, BTK-K, and Masket-K may yield more accurate calculation results. At the current stage, AI-based formulas do not demonstrate significant advantages over conventional formulas. However, the application of historical data can enhance the performance of these formulas.
Cramér moderate deviations and Berry-Esseen bounds for Mandelbrot’s cascade in a random environment
Authors: Li Yingqiu , Li Peihan , Wei Yushao 
Published: June 2023

Abstract
Let (Y n) be a Mandelbrot’s cascade in an independent and identically distributed (i.i.d.) random environment ξ. According to the existence of the annealed Laplace transform of the limit variable W = lim n→∞ W n , where W n = Y n /E ξ Y n is the normalized population size, and with the use of the associated random walks, Cramér moderate deviations and Berry-Esseen bounds for log Y n under the annealed law P are established. It is also shown that harmonic moments of Mandelbrot’s martingale (W n) exist.
2010 MSC: 60J80, 60K37, 60F10
Preemptive QP001 provides analgesia and reduces opioid consumption in subjects with moderate to severe pain following abdominal surgery: a randomized controlled trial
Authors: Zhou YingYong , Wang Bin , Duan Kaiming , Bai Zhihong , Hu Xianwen , Xu Mingjun , Li Xiaohong , Gao Yuanli , Li Jiangang , Yang Mengchang , Zhang Ying , Zhang Wei , Dai Ruping , Shen Yufei , Wu Ziteng , Jiang Yan , Yu Sen , Ouyang Wen , Wang Saiying 
Published: June 2023

Abstract
Background
QP001, a novel meloxicam formulation, has been developed to manage moderate to severe postoperative pain. This study aimed to evaluate the efficacy and safety of QP001 injections for moderate to severe pain following abdominal surgery.
Method
This prospective, multicenter, randomized, double-blind, placebo-controlled clinical trial enlisted patients experiencing moderate to severe pain following abdominal surgery. These patients were randomized to receive either QP001 injections (30mg or 60mg) or a placebo pre-surgery. The primary efficacy endpoint was the total morphine consumption within 24 hours after the first administration.
Results
A total of 108 patients were enrolled, and 106 patients completed the study. The total morphine consumption in the QP001 30mg group and 60mg group were significantly lower than that in the placebo group within 24 hours after the first administration (mean [SD] 5.11[5.46] vs 8.86[7.67], P = 0.011; 3.11[3.08] vs 8.86[7.67], P < 0.001). Compared with the placebo group, the total morphine consumption in the QP001 30mg and 60mg groups significantly decreased within 48 hours and 24–48 hours after the first administration (P ≤ 0.001); the area under curve of pain intensity-time and the effective pressing times of analgesic pump within 24 h and 48 h after the first administration was significantly reduced (P < 0.05). The QP001 groups did not show more Adverse Events and Adverse Drug Reactions than the placebo group(P > 0.05).
Conclusion
Preemptive QP001 provides analgesia and reduces opioid consumption in subjects with moderate to severe pain following abdominal surgery, while maintaining a favorable safety profile.
Synthesis, Crystal structure, Hirshfeld surface analysis and DFT studies of 2-bromo-4,6-bis(dibromoacetyl)resorcinol
Authors: K Loganathan , A. Anandan , M Purushothaman , P. Daniel Jebaraj , K. Thanigaimani , Percino Judith M. , Perumal Venkatesan 
Published: June 2023

Abstract
The synthesis and crystal structure of 2-bromo-4,6-bis(dibromoacetyl)resorcinol, I, was reported. In the title compound, I, crystalized in the triclinic crystal system with Pī space group. The two carbon and the oxygen atom of the acetyl groups (atoms C7, C8, O3, and C9, C10, O4) are nearly co-planar with the central phenyl ring. Intramolecular O–H···O, C–H···Br, and intermolecular C–H···Br/O interactions, two non-bonded contacts (Br5···Br3 and O4···C8) and π-π stacking interaction are stabilized the crystal packing of the title compound. Intermolecular interactions that exist in the title compound, I, are quantified with the aid of PIXEL and Hirshfeld surface (HS) analysis and the decomposed fingerprint (FP) plots. The FP plot reveals that the Br···Br contacts are comparably higher than the other contacts in the title crystal structure. Furthermore, the theoretical density functional theory (DFT) calculations were performed at the M062X /cc-PVTZ level of theory. The experimental geometry parameters of the title molecule are compared with the geometry of the optimized molecule in the gas phase. The chemical reactivity and charge transfer properties of the title compound were calculated from the HOMO and LUMO energy. In addition, the molecular electrostatic potential map was generated at their crystal structure geometry and quantitatively analyzed.
Maximizing Permeate Flux of IPA Dehydration via Optimizing Pervaporation Condition Through Central Composite Design (CCD)
Authors: Wahab Mohamad Syafiq Abdul , Rahman Sunarti Abd , Samah Rozaimi Abu 
Published: June 2023

Abstract
This paper reports a study on the operating condition of a pervaporation system for IPA dehydration. The two-condition study within this system is amount of water contents in binary feed mixture and operating temperature. The highest possible flux obtained from this study is at 12 wt% − 14 wt% of water in IPA and 61 ℃ – 65 ℃ operating temperature with permeate of 1.514 Kgm–2h–1 – 1.562 Kgm–2h–1. A permeate flux model for this system also been generated and validated with error margin less than 1% proving the genuine of the developed model and the ability of data prediction.
A Box-Behnken design optimization based ecofriendly RP-HPLC method For Estimation of sofosbuvir And velpatasvir - Application to stability indicating assay
Authors: Bairam Ravindar , Tatapudi Hemant Kumar , Gajji Neelamma , Tammineni Narendra , Cheepurupalli Prasad 
Published: June 2023

Abstract
In this study, a novel, cost effective, accurate, and ecofriendly stability-indicating RP-HPLC technique was developed and validated for the simultaneous measurement of sofosbuvir (SOF) and velpatasvir (VEL) in tablet dosage form. Box-Behnken design was used for multivariate optimization of the experimental parameters of RP-HPLC. The molarity of heptane sulfonic acid sodium salt (HSA), volume of ethanol, and volume of acetonitrile were used to develop mathematical models and study the effects of these factors on various responses. Heptane sulfonic acid sodium (1mM) : acetonitrile : ethanol (80 : 11 : 9 v/v) as the mobile phase, made up the optimal and expected condition. The SOF and VEL retention times were found to be 5.505 and 3.472 minutes, respectively. System suitability, specificity, accuracy, linearity, precision, and solution stability were all considered in the method's validation. For SOF and VEL, linearity was shown across the concentration range of 20–100 µg/ml and 5–25 µg/ml, respectively with correlation coefficient (R2) > 0.999. Studies on forced degradation under acid, basic, oxidative, photolytic, and thermal conditions revealed the drug's well-resolved peak and the degradation products' peaks as well. For the simultaneous determination of sofosbuvir and velpatasvir in conventional laboratory analysis, this newly suggested approach is one that is quick, reliable, and cost-effective. Furthermore, the greenness was analyzed utilizing four cutting-edge metrics, including GAPI, AES, AMGS, and AGREE, and the greenest findings were determined.
Assessment of the Soil Organic Carbon Stock (SOCS) of Foumban (West Cameroon)
Authors: Tedontsah Vivien Piercy Lotse , Mamdem Lionel Bitom , Mbog Michel Bertrand , Ngon Gilbert François Ngon , Jiague Roony Roy Choumele , Djatsa Kevin Guedia , Wantou Emmanuel Ngueko , Edzoa Robert Christel , Tassongwa Bernard , Bitom Dieudonné , Etame Jacques 
Published: June 2023

Abstract

This study aims to assess the organic carbon stock and the amount of organic carbon sequestered in the soils of Foumban, in order to facilitate climate change mitigation policies. To achieve this objective, ninety soil samples were collected from a depth of 0-30cm from the reference soil groups identified in the study area and transported to the laboratory where bulk density and organic carbon analyses were carried out to estimate the SOC stock. The SOC stock and carbon quantity calculations showed that the carbon stock in the soils of the study area varies from 64.10 t/ha in FRAGISOLS (plaggic) cambic to 116.52 t/ha in UMBRISOLS pretic, with an overall average of 88.95 ± 18.61 t/ha. The total amount of organic carbon stored in the soils is estimated to be about 85.79×10− 4GT. It varies from 1.30×10− 4GT in cambic hortic FERRALSOLS (plaggic) on trachytes to 17.13×10− 4GT in chernic arenic UMBRISOLS. The variation in carbon stock in the study area would be due to the variation in the density of the vegetation cover. The input of organic amendments would contribute to the increase of organic carbon stocks in these soils.
Numerical modelling of electronic and optical properties for different sizes of CdSe/ZnS quantum dots under temperature and hydrostatic pressure effects
Authors: Brahim Tesnim , Bouazra Adel , Said Moncef 
Published: June 2023

Abstract
In his paper, the electronic and optical properties of different sizes of CdSe/ZnS quantum dots (QDs) are theoretically investigated. The energy eigenvalues and wave functions dependence on QD dimension, temperature and pressure are calculated by using the combination of coordinate transformation and the finite difference method (FDM). The oscillator strength, transition lifetime, absorption coefficients (AC) and refractive index changes (RIC) are brought out for various values of dots sizes, temperature, hydrostatic pressure, and incident photon intensity. The obtained results indicated that the electronic and optical properties are strongly dependent on the temperature, hydrostatic pressure and on the size of the nanostructure. The oscillator strength decreased as the hydrostatic pressure increased, but increased as the temperature increased, the opposite behavior has observed for the transition lifetime. Moreover, the total of AC and RIC increase by decreasing the incident optical intensity. Linear, nonlinear, and total AC and RIC displays a red shift (blue shift) with increasing the hydrostatic pressure (temperature).
Impact of climatic factors on temporal variability of sand fly abundance in Sri Lanka: Longitudinal study (2018 to 2020) with two-stage hierarchical analysis.
Authors: Senanayake Sanath C , Liyanage Prasad , Pathirage Dulani R.K. , Siraj M. F. Raushan , De Silva B. G. D. Nissanka Kolitha , Karunaweera Nadira D 
Published: June 2023

Abstract

Background
Phlebotomine sand flies serve as vectors for leishmaniasis, a major health concern, but a neglected tropical disease. The risk of vector activity is governed by climatic factors that vary in different geographic zones in the country. Thus, we aimed to quantify the effect of climatic variables on sand fly vector activity in ten sentinel sites across Sri Lanka.
Methods
Mean rainfall, ambient temperature, relative humidity, wind speed, soil temperature, evaporation, sunshine hours, and vector densities were recorded at monthly intervals in each location from March 2018 to February 2020. The association between weather variables and sand fly densities was analysed using a two-staged hierarchical procedure; Distributed Lag Non-Linear (DLNM) modelling framework and the DLNM method implemented in the R package dlnm (version number 2.4.6).
Results
Moderate rainfall values up to 120 mm per month and increasing RH up to 82 at lag of 0 months along with increasing soil temperature and evaporation rate at lag of 2 months were associated with statistically significant increase in the sand fly activity. These associations were heterogeneous across study settings. Whereas increasing ambient and soil temperature, sunshine hours, evaporation rate appeared to reduce the sand fly activity homogeneously at lag of 0 month in all the study settings.
Conclusions
The abundance of sand fly vectors varied in relation to selected climatic variables, either in real-time or with a time lag. This information can be utilized for predicting sand fly densities and for the development of effective strategies to prevent leishmaniasis transmission in specific settings.
‘Self-stigma’ of people with cutaneous leishmaniasis the unrecognized one: what do we think; what do we know; what can we prove?
Authors: Hagos Binega , Zerihun Zenawi 
Published: June 2023

Abstract
Cutaneous leishmaniasis (CL) refers to a group of parasitic infections caused by the protozoan parasite Leishmania spp. Lack of knowledge and awareness regarding this disease creates a burden for patients with CL to deal with self-stigma. The aim of this ethnographic study is to provide an analysis of self-stigma experienced by patients with CL through an in-depth understanding of the self-stigma experienced by patients with cutaneous leishmaniasis. A qualitative data analysis approach was used for this study. Semi-structured interviews and participant observation were conducted with 33 individuals with CL, and data were analyzed using a thematic analysis method. Interviews revealed that individuals with CL experience severe self-stigma. The participants spoke of their struggle to live with physical appearances that differed from societal norms. Furthermore, they also highlighted that people with CL are often viewed as unclean and contagious, which further adds to their self-stigma. Fear of social exclusion often forced individuals with CL to isolate themselves, leading to a detrimental impact on their mental health and quality of life. This study provides valuable insights into the experiences of patients with CL who are subjected to self-stigma. The findings suggest that the lack of knowledge and the considerable misconceptions surrounding CL create barriers for patients to deal with the condition and the self-stigma attached to it. To address this issue, there is a need for dedicated public health campaigns and health education that increase awareness about CL and provide appropriate support and care for those affected.
Return-to-Work coordinators’ perceptions of their roles relative to workers: A discourse analysis
Authors: Hopwood Pamela , MacEachen Ellen , Crouch Meghan , Neiterman Elena , McKnight Ekaterina , Malachowski Cindy 
Published: June 2023

Abstract

Purpose This paper describes how Canadian Return to Work coordinators’ (RTWC) framed their job roles relative to workers in ways that went beyond the usual professional norms of helping worker recovery.Methods In-depth interviews were conducted with 47 RTWCs across Canada in 2018–2019. We used critical discourse analysis to analyze the way coordinators viewed workers in the complex, multi-stakeholder system of RTW.Results We identified four ways that RTWCs positioned themselves relative to workers: as trustworthy, experts, detectives and motivators. These roles reflected RTWCs position within the system; however, their discourse also contributed to the construction of a moral hierarchy that valued worker motivation and framed some workers as attempting to exploit the RTW system.Conclusions RTWC’s positions of power in the coordination process warrant further investigation of how they exercise judgement and discretion, particularly when the process depends on their ability to weigh evidence and manage cases in what might be seen as an objective and fair manner.
Turbulence in The Strongly Heterogeneous Near-Surface Boundary Layer over Patchy Snow
Authors: Haugeneder Michael , Lehning Michael , Stiperski Ivana , Reynolds Dylan , Mott Rebecca 
Published: June 2023

Abstract
The near-surface boundary layer above patchy snow cover in mountainous terrain is characterized by a highly complex interplay of various flows on multiple scales. In this study, we present data from a comprehensive field campaign that cover a period of 21 days of the ablation season in an alpine valley, from continuous snow cover until complete melt out. We recorded near-surface eddy-covariance data at different heights and investigate cospectral decompositions.The topographic setting led to the categorisation of flows into up and down valley, with most flows being thermally driven except for a Föhn event in the middle of the observation period. Our findings reveal that the snow cover fraction is a major driver for the structure and dynamics of the atmospheric layer adjacent to the snow surface. With bare ground emerging, stable internal boundary layers (SIBL) developed over the snow. As the snow coverage decreased, the depth of the SIBL decreased and cospectra of air temperature variance showed a transition towards turbulent time scales, which were caused by the intermittent advection of shallow plumes of warm air over the snow surface.In addition, our analysis of vertical profiles of turbulence kinetic energy indicates that the distribution of eddy size and, thus, the turbulence structure, did not significantly change towards the surface. However, the SIBLs caused a thermal decoupling of the atmospheric layer adjacent to the snow surface. We complement these findings by presenting high spatio-temporal resolution air temperature profiles.
Multiscale Computational Modeling of Aortic Valve Calcification
Authors: Azimi-Boulali Javid , Mahler Gretchen J. , Murray Bruce T. , Huang Peter 
Published: June 2023

Abstract
Calcific aortic valve disease (CAVD) is a common cardiovascular disease that affects millions of peopleworldwide. The disease is characterized by the formation of calcium nodules on the aortic valve leaflets,which can lead to stenosis and heart failure if left untreated. The pathogenesis of CAVD is still notwell understood, but involves several signaling pathways, including the transforming growth factorbeta (TGFβ) pathway. In this study, we developed a multiscale computational model for TGFβ-stimulated CAVD. The model framework comprises cellular behavior dynamics, subcellular signalingpathways, and tissue-level diffusion fields of pertinent chemical species, where information is sharedamong different scales. Processes such as endothelial to mesenchymal transition (EndMT), fibrosis, andcalcification are incorporated. The results indicate that the majority of myofibroblasts and osteoblastlikecells ultimately die due to lack of nutrients as they become trapped in areas with higher levels offibrosis or calcification, and they subsequently act as sources for calcium nodules, which contributeto a polydispersed nodule size distribution. Additionally, fibrosis and calcification processes occurmore frequently in regions closer to the endothelial layer where the cell activity is higher. Our resultsprovide insights into the mechanisms of CAVD and TGFβ signaling and could aid in the developmentof novel therapeutic approaches for CAVD and other related diseases such as cancer. More broadly,this type of modeling framework can pave the way for unraveling the complexity of biological systemsby incorporating several signaling pathways in subcellular models to simulate tissue remodeling indiseases involving cellular mechanobiology.
Development of a Simulation Model for Analysis, Desing and Control of a Product Package Training Platform
Authors: YILMAZ Serhat 
Published: June 2023

Abstract
Backgorund:
In this paper, modelling and simulation of a prototype product-box assembly automation system, which has designed for control laboratories is presented. Prototype automation systems and their mathematical models are valuable tools for control education and research. The paper describes background and working principle of the prototype system, which is modelled by Simulink, block diagrams.
Methods:
Control applications of Proportional Integral Derivative (PID, Fuzzy Inference System (FIS), Adaptive Neurofuzzy Inference System (ANFIS) methods are observed and their performances are compared.
Results:
Once mathematical model (MM) of the automation system is ensured, evidences and performances of analysis and design methods thought in the lessons could be examined by means of various control applications on the model.
The foremost contribution of the study is in the drawing out of a new teaching and development model for control engineering and the different supplied methods for an effective design of such tools.
Voltammetric determination of Hg (II) using poly (methane disulfide)/Au nanoparticle/MWCNT modified glassy carbon electrode by differential pulse anodic stripping voltammetry (DPASV) technique
Authors: Ghalebi Seyedeh Mina , Parham Hooshang , Shirmardi Abbas 
Published: June 2023

Abstract
In the present work, surface of a glassy carbon electrode (GCE) was modified by a poly (methanedisulphide)/Au–nanoparticles/multiwall carbon nanotubes (PMDS/AuNPs/MWCNT) to improve its ability for the determination of trace mercury cations in polluted water. The produced electrode was characterized with FESEM, HR-TEM, AFM, XRD, and FT-IR techniques. The obtained results proved the successfulness of the modification process and revealed that the process had a significant effect on the morphology of the electrode and its surface roughness. EIS studies demonstrated the improvement of the electrochemical properties of the surface modified sample. Accordingly, the electrical resistance to charge transfer (Rct) of the GCE-based samples decreased from 477.1 Ohm.cm2 for the bare sample to 83.4 Ohm.cm2 for the modified-GCE sample. The modified-GCE sample was employed as an ultra-sensitive electrode for determining the concentration of Hg2+ cation based on DPASV technique. It exhibited linear behaviour for the concentration determination in the range of 5.98×10− 12 M to 1.00×10− 9M with correlation coefficient of 0.996. Limit of detection (LOD) and limit of quantitation (LOQ) of the method were found 2.73×10− 13 M and 9.19×10− 13 M, respectively.