bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mammalian cell characterisation by non-invasive plate reader assay
Authors: Grob Alice , Bena Chiara Enrico , Di Blasi Roberto , Pessina Daniele , Sood Matthew , Yunyue Zhou , Bosia Carla , Isalan Mark , Ceroni Francesca 
Published: March 2023

AbstractAutomated and non-invasive mammalian cell analysis is currently lagging behind due to a lack of methods suitable for a variety of cell lines and applications. Here, we report the development of a high throughput non-invasive method for tracking mammalian cell growth and performance based on plate reader measurements. We show the method to be suitable for both suspension and adhesion cell lines, and we demonstrate it can be adopted when cells are grown under different environmental conditions. We establish that the method can inform on effective drug treatment to be used depending on the cell line considered, and that it can support characterisation of engineered mammalian cells over time. This work provides the scientific community with a novel approach to mammalian cell screening, also contributing to the current efforts towards high throughput and automated mammalian cell engineering.
Elite women's schools across three Australian states in the 1930s: a prosopographical study
Authors: May Josephine 
Published: March 2023

PurposeThis paper presents a descriptive analysis of elite women's biographical sketches in Who's Who-type collections, now out of copyright, published in Australia in the 1930s: Victoria (1934), New South Wales (1936) and Queensland (1939). It concentrates on information given about their schooling.Design/methodology/approachThe biographical sketches of the women, defined as “elite” by their inclusion in three collections from the 1930s, were examined for information about their and their daughters' education. Using mixed methods in a prosopographical approach, this is mainly a quantitative analysis. It outlines and compares the schools they attended where given as well as providing basic demographic details of the 491 women.FindingsThe paper shows that, for those who gave educational details, the women and their daughters attended private schools almost exclusively. Three types of schools were listed – private venture, corporate, and a very few state schools. The paper demonstrates that the landscape for girls’ secondary schooling was not a settled terrain in terms of type, place, religion, or age of schools available for elite girls' education in the late 19th and early 20th century. Private schools are shown to be part of the “machinery of exclusiveness which characterised the inter-war years” (Teese, 1998, p. 402) and private venture schools survived well into the third decade of the 20th century.Originality/valueBeyond the histories of individual schools, little is known about the educational profile of Australian elite women in the past. This largely quantitative analysis helps to uncover and compare across state-based cohorts, previously unknown demographic, and schooling details for interwar women who recorded their educational details, as well as for the NSW and Victorian daughters where given.
The effect of charity website design on perceived consistency and its consequences
Authors: Kwak Dong-Heon , Nazareth Derek L. , Lee Saerom , Lee Jinwoong , Polites Greta L. , Knapp Deborah Erdos 
Published: March 2023

PurposeDrawing upon the consistency literature, the theory of visual rhetoric and social judgment of warmth and competence, this study examines the determinants and impacts of perceived interface design consistency in the context of charity websites.Design/methodology/approachTo identify design factors of perceived interface design consistency, this study separates charity website interface design into two aspects: main appeal design (i.e. appeal quality) and peripheral design (i.e. image type). The authors designed a two (appeal quality: low vs high) × three (image type: control vs adults vs children) controlled lab experiment to investigate the effects of various interface choices. A total of 217 subjects participated in the experiment. The authors used structural equation model (SEM) analysis and analysis of covariance (ANCOVA) to test the research hypotheses.FindingsThis study found that appeal quality and human images increase perceived interface design consistency. The authors also found that the relationship between appeal quality and perceived interface design consistency is moderated by image type. Finally, the authors showed that perceived interface design consistency increases perceived warmth and competence of charity websites, which in turn affect intention to use the website for donations.Originality/valueThe authors’ findings provide novel insights for theory on consistency and interface design and practical implications for charity website designers by identifying determinants and consequences of perceived interface design consistency.
The informativeness of dividend ratios and their economic predictive value towards equity premium
Authors: Awad Ali A. , Al-Hamadeen Radhi , Alsharairi Malek 
Published: March 2023

PurposeThis paper aims to examine and compare the dividend ratios’ statistical and economic ability to predict the equity premium in the UK and US markets and two US sub-indices (S&P 500 Growth and S&P 500 Value).Design/methodology/approachIn this paper, the authors use the linear regression models to examine the dividend ratios’ statistical ability to predict the equity premium. The in-sample and out-of-sample approaches, including Diebold and Mariano (1995) statistics, and Goyal and Welch’s (2003) graphical approach, are used. Also, the mean-variance analysis is used to test the economic significance.FindingsThe paper findings indicate that the dividend ratios have in-sample and out-of-sample predictive abilities in both UK and US markets and both US sub-indices. However, the results show that the dividend ratios have a less impressive predictive ability in the US market compared to the UK market and less in the US value index than the US growth index. This could indicate that there is no relation between the number of companies that distribute dividends in each index and the informativeness of dividends ratios. Furthermore, the tests show the dividend ratios’ predictive ability departure during particular periods and in some indices.Research limitations/implicationsResults and implications of this research are exclusively applied to the US and UK markets. These results can also be applied with caution to other markets, taking into consideration the distinctive characteristics of these markets.Practical implicationsResults revealed in this paper imply that the investors in any of the indices may experience economic gain by adopting a dynamic trading strategy using the information content of the dividend ratios prediction models instead of the benchmark model, which is the prevailing simple moving average model.Originality/valueThis paper adds value through testing the prediction models’ economic significance in two well-developed markets, in addition to exploring the relationship between the number of companies distributing cash dividends and the dividends ratio prediction ability. Unlike most of the previous studies in which dividend ratios’ prediction ability is attributed to the number of companies that distribute dividends in the market, this paper denied this interpretation by studying two S&P 500 sub-indices. To the best of the authors’ knowledge, this is the first study to test the prediction models’ ability for these sub-indices.
A chopper amplifier with a pseudo MOS resistor-based tunable bandwidth for EEG applications
Authors: Sajja Amrita , Rooban S. 
Published: March 2023

Purpose
The purpose of chopper amplifier is to provide the wideband frequency to support biomedical signals.

Design/methodology/approach
This paper proposes a chopper-stabilized amplifier with a cascoded operational transconductance amplifier. The high impedance loop is established using an MOS pseudo resistor and with a tunable MOS capacitor.

Findings
The total power consumption is 451 nW with a supplied voltage of 800 mV. The Gain and common mode rejection ratio are 48 dB and 78 dB, respectively.

Research limitations/implications
All kinds of real time data analysis was not carried out, only few test samples related to EEG signals are validated because the real time chip was not manufactured due to funding issues.

Practical implications
The proposed work was validated with Monte-Carlo simulations. There is no external funding for the proposed work. So there is no fabrication for the design. But post simulations are performed.

Originality/value
The high impedance loop is established using an MOS pseudo resistor and with a tunable MOS capacitor. To the best of the author’s knowledge, this concept is completely novel and there are no publications on this work. All the modules designed for chopper amplifier are new concepts.
Sensory irritation to methylparaben is caused by its low metabolism in the skin
Authors: Ninomiya Rie , Nishijima Takafumi , Aoshima Masahiro , Sakaguchi Hitoshi , Tokura Yoshiki 
Published: March 2023

AbstractSensitive skin is a well‐ known skin condition showing sensory irritation to daily used products such as cosmetics or pharmaceuticals, possibly containing sensory irritants. Methylparaben (MP), widely used as a preservative, is a representative sensory irritant and hydrolyzed in the skin. We aimed to clarify the relationship between MP sensory irritation and MP hydrolysis. First, we investigated the percutaneous penetration and hydrolysis of MP by using an ex vivo pig skin system and confirmed that topically applied MP was immediately hydrolyzed to p‐hydroxybenzoic acid (PHBA). We next evaluated whether MP or PHBA causes sensory irritation using a well‐used stinging test in human skin and found that MP, but not PHBA, induced irritation. Additionally, MP, but not PHBA, increased intracellular calcium in cultured TRPA1‐expressed HEK293 cells, supporting the stimulatory activity of MP. Five and 10 individuals with sensitive and non‐sensitive skin, respectively, were selected by a questionnaire and stinging test. In their biopsied skin samples, MP hydrolytic activity was significantly lower in sensitive than non‐sensitive skin. Finally, we examined the activity of carboxylesterase (CES), which promptly hydrolyzes MP to PHBA. By using specific inhibitors of CES and CES2, we found that CES1 was responsible for MP metabolism. Our study suggests that low skin metabolism of topical agents is one of the causes of skin sensory irritation and resultant sensitive skin.
Branching into heritage: the genesis of the Anne Frank Tree and its multiplications
Authors: Stengs Irene 
Published: March 2023

AbstractThis ethnography contributes to the field of Holocaust heritage studies by exploring the paradoxical tendencies of memorial proliferation and oblivion. The topic of investigation is the genesis and multiplications of the so‐called ‘Anne Frank Tree’, the horse chestnut tree behind the Secret Annex that Anne Frank wrote about in her diary. Fungus‐infected, the tree fell in 2010. The Anne Frank Tree testifies to both the terrible fate of the European Jews and the shelter offered to some. Therefore, its eventual safeguarding, whether by conservation or multiplication, became a topic of concern worldwide. Following the roots and routes of the Anne Frank Tree legacy (stump, seedlings, grafts, wood, and chestnuts), this article examines the processes of sacralization that have stirred the material's vivid proliferation and, importantly, the burden which the accumulating material subsequently imposes on the people in charge of it. The case sheds light on the tendency of the sacred to proliferate, often to the extent of excess. Paradoxically, this tendency threatens to undo the sacrality.
Review article: Non‐penetrating neck artery dissection in young adults: Not to be missed!
Authors: Deen Raeed , Austin Calyb , Bullen Andrew 
Published: March 2023

AbstractYoung adults who present to the ED with neck pain following non‐penetrating, seemingly trivial trauma to the neck, are at risk of neck artery dissection and subsequent stroke. Sport‐related neck injury is the chief cause. Physical examination may often be unremarkable, and although there may be reluctance to expose young patients to radiation, radiological imaging is central to making a diagnosis of arterial wall disruption. A comprehensive literature search was performed in relation to neck artery dissection, and the evidence was scrutinised. We discuss the typical mechanism of injury, symptoms, anatomical considerations and clinical aids in diagnosis of neck artery dissection. Although the incidence is low, neck artery dissection has a mortality of 7%. As such, it is important for front‐line physicians to have a high suspicion of the diagnosis and a low threshold to organise radiological examinations, specifically computerised tomography. Early detection of neck artery dissection will trigger clinical protocols that call for multi‐disciplinary team management of this condition. In general, guideline‐based recommendation for the management of neck artery dissection involving an intimal flap is by anti‐platelet therapy while treatment of neck artery dissection that results in a pseudo‐aneurysm or thrombosis is managed by surgical intervention or endovascular techniques. Close follow up combined with antithrombotic treatment is recommended in these individuals, the goal being prevention of stroke.
The reverse transcriptase inhibitor 3TC protects against age‐related cognitive dysfunction
Authors: Wahl Devin , Smith Meghan E. , McEntee Cali M. , Cavalier Alyssa N. , Osburn Shelby C. , Burke Samuel D. , Grant Randy A. , Nerguizian David , Lark Daniel S. , Link Christopher D. , LaRocca Thomas J. 
Published: March 2023

AbstractAging is the primary risk factor for most neurodegenerative diseases, including Alzheimer's disease. Major hallmarks of brain aging include neuroinflammation/immune activation and reduced neuronal health/function. These processes contribute to cognitive dysfunction (a key risk factor for Alzheimer's disease), but their upstream causes are incompletely understood. Age‐related increases in transposable element (TE) transcripts might contribute to reduced cognitive function with brain aging, as the reverse transcriptase inhibitor 3TC reduces inflammation in peripheral tissues and TE transcripts have been linked with tau pathology in Alzheimer's disease. However, the effects of 3TC on cognitive function with aging have not been investigated. Here, in support of a role for TE transcripts in brain aging/cognitive decline, we show that 3TC: (a) improves cognitive function and reduces neuroinflammation in old wild‐type mice; (b) preserves neuronal health with aging in mice and Caenorhabditis elegans; and (c) enhances cognitive function in a mouse model of tauopathy. We also provide insight on potential underlying mechanisms, as well as evidence of translational relevance for these observations by showing that TE transcripts accumulate with brain aging in humans, and that these age‐related increases intersect with those observed in Alzheimer's disease. Collectively, our results suggest that TE transcript accumulation during aging may contribute to cognitive decline and neurodegeneration, and that targeting these events with reverse transcriptase inhibitors like 3TC could be a viable therapeutic strategy.
An integrative approach to assess non‐native iguana presence on Saba and Montserrat: Are we losing all native Iguana populations in the Lesser Antilles?
Authors: van den Burg M. P. , Goetz M. , Brannon L. , Weekes T. S. , Ryan K. V. , Debrot A. O. 
Published: March 2023

AbstractInvasive alien species are among the main drivers of the ongoing sixth mass extinction wave, especially affecting island populations. Although the Caribbean is well‐known for its high species richness and endemism, also for reptiles, equally important is the regional contribution of non‐native species to island biodiversity. The Lesser Antilles encompass high genetic diversity in Iguana, though most native populations either have gone extinct or are declining following competitive hybridization with invasive non‐native green iguanas. Here, we assessed non‐native presence in two poorly‐studied native melanistic Iguana iguana populations using available genetic tools and explored utilizing size‐dependent body measurements to discriminate between native and non‐native iguanas. Genetic samples from Saba and Montserrat were genotyped across 17 microsatellite loci with STRUCTURE, and multivariate analyses indicating non‐native iguana presence only on Saba. This was corroborated by mtDNA and nDNA sequences, highlighting a non‐native origin in Central America and the ABC islands. We identified preliminary evidence suggestive of hybridization. Morphological variation among size‐dependent characteristics showed that non‐native iguanas have significantly larger subtympanic plates than native iguanas. Non‐native individuals also differed in scalation and coloration patterns. Overall, our findings demonstrate the need for continuous monitoring of non‐native iguanas within remaining native Iguana populations in the Lesser Antilles, as those not directly threatened by non‐native green iguanas are restricted to only 8.7% of the historic range. Although genetic data allow for the identification of non‐native or hybrid iguana presence, this field‐to‐lab workflow is time‐consuming. Rapid in‐situ identification of non‐native individuals is crucial for conservation management. In addition to patterns of scalation and coloration, we have highlighted the utility of size‐dependent variables for rapid diagnosis. We urge regional partners to build morphometric databases for native Iguana populations allowing the quick detection of future incursions of non‐native green iguanas and the rapid implementation of effective countermeasures during the early phase of invasion.
Local knowledge of the impact of uncontrolled fires on ecosystem services: A case study in the Pendjari Biosphere Reserve in Benin (West Africa)
Authors: Houehanou D. T. , Yaoitcha A. S. , Edalo V. , Ahoyo C. C. , Habiyaremye Muhashy F. , Assogbadjo A. E. , Janssens de Bisthoven L. , Houinato M. R. B. , Sinsin A. B. 
Published: March 2023

AbstractEcosystem services are fundamental to people and are undergoing many threats such as uncontrolled fire. Local knowledge has been widely used to guide management decisions for plant biodiversity. Therefore, we assessed the knowledge of the people of Pendjari Biosphere Reserve (PBR) on the impact of fire on ecosystem services (ES). A semi‐structured questionnaire with three fire impact levels (no, low and high) was used to interview 150 randomly selected households in four ethnic groups. The generalised linear model (GLM) was performed on the relative frequency of quotations to assess the effect of ethnic group, age and sex for each impact level of fire on ES and also to test the interaction among the considered factors. The local people reported that uncontrolled fire causes damage to many provisioning ES. The local knowledge concerning the impact of fire on ES was affected significantly (p < 0.0001) by ethnic group, age and sex irrespective of the impact level of fire on ES. Moreover, there was no significant interaction among the considered factors. The studied factors are benchmarks to be integrated into awareness and preservation measures of ES to mitigate the impact of uncontrolled fire practices in the study area.
Letter: should we abandon FIB‐4 to characterise noninvasively patients with NAFLD? Authors' reply
Authors: Henry Linda , Younossi Zobair 
Published: March 2023

LINKED CONTENTThis article is linked to Younossi et al papers. To view these articles, visit https://doi.org/10.1111/apt.17346 and https://doi.org/10.1111/apt.17422
The influence of Islam in shaping organisational socially responsible behaviour
Authors: Koleva Petya , Meadows Maureen , Elmasry Ahmed 
Published: March 2023

AbstractThe role of religion in ethical decision‐making, both for individual managers and at an organisational level, remains elusive due to contrasting findings in extant literature. This is exacerbated by a dearth of studies focusing on specific religious mechanisms that can foster ethical decision‐making, particularly with respect to organisational corporate socially responsible (CSR) behaviour and in backgrounds different from Christianity. This exploratory study investigates the mechanisms in Islam that can influence individual/micro‐ and organisational/meso‐level ethical decision‐making, and hence CSR outcomes. It draws on in‐depth, qualitative data from 63 domestic organisations in Saudi Arabia, the United Arab Emirates and Oman. The findings reveal a complex macro‐normative religious environment, founded on specific factors that shape ethics and decision‐making. Internalised by organisational leaders, these factors translate into organisational CSR behaviour as the organisation becomes a place for fulfilling individual religious responsibilities and even creates CSR products shaped around religious principles. The study contributes to the literature on ethical decision‐making, organisational behaviour and Islamic CSR and offers recommendations for policymakers and practitioners on integrating religion within the organisation.
Children's sympathy moderates the link between their attentional orientation and ethical guilt
Authors: Mehrotra Mishika , Dys Sebastian P. , Malti Tina 
Published: March 2023

AbstractThis study examined how children's attentional orientation towards environmental cues, dispositional sympathy and inhibitory control were associated with their ethical guilt. Participants were 4‐ and 6‐year‐old children (N = 211; 55% male) from ethnically diverse backgrounds. To assess ethical guilt, children were presented with two vignettes depicting ethical violations and reported how they would feel and why, if they had committed those transgressions. Using eye tracking, we calculated attentional orientation as the percentage of time children attended to other‐oriented (i.e., victim) minus self‐serving (i.e., object gained by transgressing) cues during these vignettes. Children also reported on their sympathy and completed an observational measure of inhibitory control. Although main effects were not significant, sympathy moderated the link between attentional orientation and ethical guilt: attentional orientation was positively associated with ethical guilt for children with low levels of sympathy but had no effect among those high in sympathy. These findings suggest that practices centred on prompting children to attend to other‐oriented cues – and away from self‐serving ones – may be effective particularly for children who are generally less sympathetic.