bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation des pertes post-récolte dans la filière maïs : Cas du maillon production au Bénin
Authors: Sossou Hervé Comlan , Ayedoun Alfred Akpado Oluwatogni , Dossouhoui Symphorien , Noukpozounkou Daniel Missimahou , Sossou Roméo , Koffi Juvénal Privaël , Dansou Valère , Houssou Paul Ayihadji 
Published: September 2023

Les pertes post-récolte dans la filière maïs entravent l’atteinte de la sécurité alimentaire et nutritionnelle, car cette céréale est la plus consommée au Bénin. La présente étude a été menée dans sept des douze départements que compte le Bénin, afin d’évaluer les pertes post-récolte que subissent les maïsiculteurs. La méthode subjective basée sur les déclarations des agriculteurs a été utilisée pour collecter des données à l’aide d’un questionnaire semi-structuré auprès de 286 producteurs. Les résultats indiquaient que les pertes intervenaient principalement lors de la récolte (0,87%), l’égrenage (0,86%), le vannage (0,85%) et le stockage (0,76%). Pour une quantité initialement produite (d’environ 4555 kg en moyenne), le taux moyen global des pertes au cours des différentes opérations considérées est de 5,78%. Les principales causes des pertes étaient : le déversement des grains et les facteurs biologiques (pourriture, moisissures et attaques des insectes). Des stratégies comme la récolte à temps, la protection des sacs de maïs avec des bâches et l’utilisation de sacs hermétiques permettaient de prévenir les pertes. Pour réduire considérablement ces pertes, des mesures et politiques d’accompagnement améliorant les capacités des acteurs, les facilités d’acquisition d’infrastructures de stockage, d’équipements/matériels de transport appropriés doivent être promues.

English title: Assessment of post-harvest losses in the maize sector: Case of the production link in Benin

Maize production has always faced the challenge of post-harvest losses which hamper the achievementof food and nutritional security. Hence, in order to assess these post-harvest losses in the maize sector, a study was conducted in seven of the twelve departments of Benin. Data collection was done using a semi-structured questionnaire administered to a calculated minimum sample of 286 producers of this crop. The subjective method which was based on the declarations/opinions of the farmers was used for the data analysis. The results indicated that the losses mainly occur at the harvest level (0.87%), ginning (0.86%), winnowing/cleaning (0.85%), and storage (0.76%). For an initially produced quantity (about 4555 kg), the overall average rate of losses along the various operations considered is 5.78%. The main causes of these losses are grain spillage and biological factors (rot, mould, insect attacks). Strategies such as harvesting on time, protecting sacks of maize with tarps, and the use of sacks that are not torn and in good condition help prevent losses. To considerably reduce these losses, accompanying measures and policies improving the capacities of the actors, the facilities for the acquisition of storage infrastructures, and appropriate transport equipment/materials must be promoted.
A Bioinformatics Approach to Male Infertility, MicroRNAs, and Targeted Genes
Authors: KAYA Murat 
Published: September 2023

Purpose: Infertility affects nearly 12% of couples worldwide, with a male factor being the primary or contributory reason in around 50% of cases. MiRNAs are essential post-transcriptional regulators in the spermatogenesis process, and dysregulated miRNAs have been shown to have harmful effects on male fertility. However, it is unclear which miRNAs are associated with infertility-related genes. The aim of this study is, to utilize various bioinformatics approaches, to identify miRNAs that may have a role in the regulation of infertility-related genes.
Materials and Methods: The study first selected genes associated with infertility from the Male Infertility Knowledge Base (MIK) database. Pathway analysis of the defined genes, PPI interaction, and hub proteins related to these genes were revealed by the Elsevier pathway collection database and Enrichr tool. Following that, miRNAs that can influence infertility-related genes were determined, and the influence of the miRNA-target gene connection on male infertility was established bioinformatically using various in silico tools like miRPathDB 2.0 tool, StarmiR, and miRNet.
Results: Male infertility associated 21genes were selected from the MIK database and 15 miRNAs were identified that are most likely to regulate these genes bioinformatically. 10 hub proteins related to defined male infertility genes were analyzed.
Conclusion: Our bioinformatic study results indicate that miR-34a-5p dysregulation may contribute to infertility through CREM, LAMP3, AGBL5, FOXM1 genes and and also miR-335-5p may cause infertility via the CFAP65, CFTR, and GAPDHS genes.
Efficacy of Deepana-Pachana, Swedana and Shamana Chikitsa in Juvenile Idiopathic Arthritis (JIA)
Authors: Bhatt Lalit Mohan  , Agrawal Neeraj  , Chandravanshi Lowkesh  , Dushyant  
Published: September 2023

Juvenile Idiopathic Arthritis (JIA) is a type of most common chronic inflammatory rheumatic disease with very little clarity about etiology and pathology. Main clinical findings: A 16-year-old adolescent female girl with the complaint of pain and swelling in knee joint bilaterally, difficulty in walking, restricted movement and pain in wrist, ankle and interphalangeal joints, morning stiffens in hand and wrist joints. Diagnosis: This case of Juvenile Polyarticular (RF positive) arthritis was diagnosed as Amavata (symptoms suggest pravridhavastha). Interventions: Treatment given for 3 months in a duration dependent pattern. Deepana, Pachana followed by Snehan, Rechana and Baluka sweda, Upnah was done along with oral medications. Outcome: Patient felt relief in pain, swelling of joints reduced, restriction of joint movement was reduced, Lakshana of Ama like Anorexia, Fatigue, Heaviness and Laziness were also relieved. Conclusion: This paper is an attempt to explore effectiveness of Ayurvedic treatment in case of JIA.
The Creative Edge
Authors: Fletcher Mary C. 
Published: September 2023

Transform your library from a place of information into a place for inspiration. Library facilitators of art-based creativity sessions will learn how to choose materials and art experiences appropriate for young people from toddlers to teens and for intergenerational groups. In the modern world, innovative and creative individuals have a distinct advantage: the creative edge. The Creative Edge explains how you can design and conduct art-based creativity programming in your library. Written by a library creativity specialist, this book is the result of the author's many years of experience facilitating art groups for all ages. Her programs have achieved national recognition and will serve as a guide for others to establish art-based creativity sessions. In this book, she incorporates research that documents the importance of creativity as an essential component of childhood development and connects it to library learning goals, including literacy. Creativity research can be applied in libraries and at other public institutions to develop programs that will meet the needs of the next generation. The book includes many practical elements, such as lists for recommended art materials, step-by-step instructions on setup and procedures, and ideas inspired by picture book illustrations that connect to story time themes. The Creative Edge teaches readers how to provide programs that promote child-led exploration, experiential learning, innovative thought, and creative confidence.
Offers a guide for creativity programming for librarians, teachers, program coordinators, and college students
Teaches how to facilitate open-ended creativity programs for children of all ages and caregivers
Describes how to design story time art groups linking art and literacy inspired by picture book illustrations
Association of health literacy and physical activity with physical fitness level among adults
Authors: Jayakumar Ramya , Tanaji Methre Seema , Namdeorao Patil Ashwini 
Published: September 2023

Introduction and Aim: ‘Health is wealth’ is the best quote heard but the importance of it is realized only when health is lost. This study aims to assess the knowledge of health information, physical activity level among the adults and correlate this with their physical fitness.

Methods: Healthy adults were recruited from the general population through simple random sampling. Physical activity, health literacy, muscle strength, endurance and flexibility were assessed using International Physical Activity Questionnaire (IPAQ), Health Literacy Survey European Questionnaire 16, hand grip test, curl up test, sit and reach test respectively. Data analysis was performed using Primer of Biostatistics (Version 7) statistical software.

Results: A total of 51 participants (36 females) with an average age of 34 years and BMI of 24.2 kg/m2 were recruited in the study. Health literacy (HL) score was found to be inadequate in 15% and limited in 37% of the studied population. Majority (62%) had low levels of physical activity. We found a strong association of health literacy, with physical activity and muscle strength, muscle endurance, flexibility and physical fitness index (p = 0.000 for all).

Conclusion: The health literacy was good, though the physical activity scores indicated more inactive people. Majority had normal muscle strength and average to above average level of flexibility, but muscle endurance was greatly affected owing to an unacceptable physical fitness index. The study demonstrates significant association between health literacy, physical activity, and physical fitness level among adults. Adequate health literacy is necessary to comprehend and utilize health information.
In vitro anticancer efficacy of Cyperus rotundus (L.) on breast adenocarcinoma cells via the induction of DNA fragmentation and apoptosis
Authors: Nidugala Hema , Prabhu Ashwini , Avadhani Ramakrishna , B. Ravishankar 
Published: September 2023

Introduction and Aim: Cyperus rotundus (L.), commonly known as nutgrass, has been in use in Indian medicine traditional system against several ailments. This investigation was performed to assess the in vitro antineoplastic activity of extracts prepared from water and ethanol with C. rotundus rhizomes.

Materials and Methods: Toxic effects induced by the C. rotundus extracts on MCF-7 breast adenocarcinoma cells was evaluated using Sulphorhodamine- B (SRB) Assay, Trypan blue assay, Hoechst nuclear staining assay, Acridine Orange-Ethidium bromide (AO-EB) differential fluorescence staining assay and DNA fragmentation assays.

Results: The results of SRB assay indicated the IC50 value of aqueous extract as 510.887 µg/mL and that of ethanol extract as 122.98 µg/mL. Trypan blue assay also indicated the similar results, wherein ethanol extract exerted higher cytotoxicity compared to the aqueous extract. MCF-7 cells treated with aqueous and ethanol extracts of C. rotundus rhizomes were exposed to Hoechst staining and AO-EB nuclear staining assays, wherein and ethanol extract induced clear apoptotic bodies in the tested cells. Further, the cells were treated with the ethanol extract and DNA fragmentation was confirmed by DNA ladder assay. MCF-7 cells administered with ethanol extract were subjected to DNA fragmentation assay for assessing the apoptosis induction nature of the extract.

Conclusion: Results from our study indicate a promising approach into the possibility of developing C. rotundus ethanol extract into an effective anticancer moiety after appropriate pre-clinical and clinical validations.
Surface roughness and bacterial adhesion on composite materials: an in vitro comparative evaluation
Authors: Sengupta Ishani , Ballal Mamatha , Mahesh Saahithya , Acharya Shashi Rashmi 
Published: September 2023

Introduction and Aim: Despite being popular, composite materials frequently degrade, and cause secondary caries in the oral cavity. Studies suggest that surface characteristics, particularly surface roughness, can impact the functionality, durability, and biofilm formation of these materials. This study was carried out to evaluate and compare the surface roughness of nano-ceramic restorative and bulk-fill flowable composite materials and their bacterial adhesion properties using Streptococcus mutans.

Materials and Methods: 16 disks of each composite type, Ceram x SphereTEC one universal nano-ceramic restorative material and SDR flow plus bulk-fill flowable material were fabricated and grouped as A and B, respectively. 2D surface roughness of the samples were recorded using Contact Profilometer. For bacterial adhesion test, samples were incubated in a culture of S. mutans overnight. Adhered bacteria were determined by spread plate technique, colonies were enumerated and reported as CFU/mL. Kolmogorov-Smirnov and Shapiro-Wilk tests helped determine normality distribution of surface roughness, and statistical significance was analysed using Independent-samples t test. Bacterial adhesion was analysed using Mann-Whitney U test.

Results: Surface roughness values were found to be normally distributed, and the difference between the two groups was noted to be statistically significant (p<0.05). However, there was no statistical difference between bacterial adhesion amongst the two materials (p>0.05).

Conclusion: Surface roughness value of the nano-ceramic restorative material was lower than that of bulk-fill flowable resin material albeit, the two composites did not show a significant difference in terms of bacterial adherence.
Genetic mutation rs972283 of the KLF14 gene and the incidence of gastric cancer
Authors: Bresam Sabah , Majid Abd Ulameer Alhumairi Rasha , M. Hade Istikrar , Abdullah Laftaah Al-Rubaii Bahaa 
Published: September 2023

Introduction and Aim: Genetic factors and family gene clustering constitute an important ratio for gastric cancer. Kruppel Like Factor 14 (KLF14) gene has a carcinogenic role and a clear role in metabolic diseases, but how this gene regulates these metabolic traits is still obscure. Previous studies proposed that the accumulation of single nucleotide polymorphisms (SNPs) in KLF14 may be associated with gastric cancer. The current study aimed to investigate whether single nucleotide polymorphisms (SNP) rs972283 in KLF14 is associated with an increased risk of gastric cancer in the Iraqi population.

Materials and Methods: The SNP was genotyped using tetra primer ARMS-PCR in 101 (79 men and 22 women) gastric cancer patients who did not receive chemotherapy, and 80 healthy controls (53 men and 27 women). All patient samples were taken from the Baghdad Hospital of Gastroenterology and Hepatology laboratories. Patient records included age, sex, histological type, and H. pylori infection status

Results: The KLF14 rs972283 genotype was significantly different between the gastric cancer and control groups. The heterozygous AG genotype and A mutant allele were significantly higher in gastric cancer patients compared to controls (56.4% vs 38.7%, p<0.01 and 61% vs 40.6%, p<0.01, respectively). In contrast, the GG wildtype genotype and G wildtype allele were significantly higher in controls (40% vs 11%, p<0.01 and 59.4% vs 39%, p<0.01, respectively). The AA homozygous mutant genotype also showed a weak correlation with increased gastric cancer risk. These results indicate the A allele is a risk factor while the G allele has a protective effect for gastric cancer.

Conclusion: the KLF14 polymorphism rs972283 exhibits a significant association with gastric cancer risk in our Iraqi cohort. The SNP may serve as a useful prognostic marker, pending validation in larger studies.
Characteristics of structural and functional alterations following traumatic brain injury in neurons and glial cells of the sensorimotor cortex
Authors: Mamytova Elmira , Monolov Nurbek , Turganbaev Bakytbek , Toktomametova Anara , Karbozova Kunduz , Kadyrova Aliya , Abaeva Tamara , Zhanganaeva Mira , Chekirbaeva Nursulu , Altynbekova Zhanara 
Published: September 2023

Introduction and Aim: Traumatic brain injury (TBI) is regarded as a significant worldwide health issue and a significant contributor to mortality and disability. The objective of this study was to examine the parameters and nature of the regenerative and destructive processes that occur in the rat cerebral cortex depending on the degree and time of the TBI.

Materials and Methods: The experiments were carried out on 24 sexless adult mice weighing 180–220 g. The primary group of mice had severe TBI. To assess the severity of the TBI model, histological data, animal survival rates, and motor and cognitive dysfunctions were examined. Both light and electron microscopy were used to study the animal brains in each group.

Results: The areas of injury were filled with blood, and microscopic examination revealed that the foci of contusion had destroyed brain tissue in the form of tissue and blood vessel fragments. Most dystrophic neuronal changes in mice with severe TBI between 1 and 21 days after the injury were acute neuronal swelling, hydropic dystrophy of nerve cells with clear cytoplasmic vacuolization, localized and complete chromatolysis, hyperchromatism, and homogeneous cytoplasm.

Conclusion: Brain tissue lesions develop in the early stages of a TBI through rapid necrotic cell death.
Upadacitinib (Rinvoq)
Authors: CADTH  
Published: September 2023

CADTH recommends that Rinvoq be reimbursed by public drug plans for the treatment of adult patients with moderately to severely active ulcerative colitis (UC) who have demonstrated prior treatment failure (i.e., an inadequate response to, loss of response to, or intolerance to at least 1 of conventional therapy and/or biologic therapy), if certain conditions are met.
Rinvoq should be covered for a similar patient population and in a similar way to other drugs currently reimbursed by public drug plans for the treatment of moderately to severely active UC.
Rinvoq should only be reimbursed if it is prescribed by a physician experienced in treating UC, the dosage does not exceed the product monograph’s recommended dosage, and it is not used in combination with biologics for UC. It should not cost more than other biologics or targeted synthetic drugs covered by the public drug plans for the treatment of moderately to severely active UC.
ПРОЕКТ СТРОИТЕЛЬСТВА БЕРЛИН-БАГДАДСКОЙ ЖЕЛЕЗНОЙ ДОРОГИ ИЕЕ ВЛИЯНИЕ НА МЕЖДУНАРОДНУЮ ПОЛИТИКУ
Authors: Абдукадыров Н.М. 
Published: September 2023

ХІХ ғасырдың соңғы ширегінде Осман империясы мен Кайзерлік Германия арасында саяси байланыстар жоғары деңгейге көтеріліп, ол уақыт өте жылдам қарқынмен дамыды. Империялар арасындағы саяси байланыстардың басты бағыттарының бірі –ХІХ-ХХ ғасырлар тоғысында салынып, «Ғасыр жобасы» аталған Берлин-Бағдат теміржолының салыну жобасы болды. Мақалада, Бағдат теміржолының салыну жобаларының Осман империясы мен Германия үшін саяси маңыздылықтары қарастырылады. Сонымен бірге, теміржолды салу жобасының халықаралық сипаты мен әсері көрсетіліп, бұл жобаға әлемдік империялардың араласу мәселелеріне тарихи талдау жасалады. Әлемдік империялар Англия мен Францияның Анадолы теміржолын Бағдатқа дейін ұзартудағы Германия мен Осман империясының саяси жобаларына қатысты саяси ұстанымдары мен осы жобаға байланысты туындаған халықаралық мәселелерді зерттеу мақаланың басты міндеттерінің бірі болып табылады.
В последней четверти XIX века политические отношения между Османской империей и кайзеровской Германией достигли высокого уровня и в то время развивались очень быстрым темпам. Одним из основных направлений политических отношений между империями было строительство железной дороги Берлин-Багдад, построенной на рубеже XIX-XX веков и получившей название «Проект века». В статье рассматривается политическое значение проекта Багдадской железной дороги для Османской империи и Германии. Кроме того, продемонстрирован международный характер и влияние проекта железной дороги, и сделан исторический анализ вмешательства мировых империй в этот проект. Одна из основных задач статьи -изучить политических позиции мировых империй Великобритании и Франции по политическим проектам Германии и Османской империи по продлению Анатолийской железной дороги до Багдада и международным вопросам, возникающим в связи с этим проектом.
In the last quarter of the 19th century, political relations between the Ottoman Empire and Imperial Germany reached a high level and developed at a very fast pace at that time. One of the main directions of political relations between the empires was the construction of the Berlin-Baghdad railway, built at the turn of the 19th-20th centuries and called the "Project of the Century". The article examines the political significance of the Baghdad railway project for the Ottoman Empire and Germany. In addition, the international character and impact of the railway project is demonstrated, and a historical analysis of the intervention of world empires in the project is made. One of the main objectives of the article is to study the political positions of Great Britain and France on the political projects of Germany and the Ottoman Empire to extend the Anatolian railway to Baghdad and international issues arising in connection with this project.
МОРФОМЕТРИЧЕСКИЕ И РЫБОВОДНЫЕ ПАРАМЕТРЫ РОСТА МОЛОДИ ОСЕТРОВЫХ РЫБ КАСПИЙСКОЙ ПОПУЛЯЦИИ В УСЛОВИЯХ РЕГУЛИРУЕМЫХ СИСТЕМ
Authors: Туменов Артур , Сариев Б.Т. , Джунусов А.М.  
Published: September 2023

В данной статье рассматриваются вопросы выращивания молоди осетровых рыб в регулируемых условиях (УЗВ). Объектом исследования является молодь осетровых рыб Каспийской популяции: белуга, стерлядь, русский осетр, шип.
В настоящие время в аквакльтурных комплексах в регулируемых условиях начаты работы по формированию ремонтно-маточных стад (РМС) чистых видов осетровых рыб. Необходимость формирования РМС чистых видов осетровых рыб, продиктована перспективами получения заказов от недрапользователей по зарыблению естественных водоемов в целях проведения компенсационных работ, а также возможностью участия в Государственном заказе по зарыблению.
Разные виды осетровых рыб значительно отличаются друг от друга темпами роста, скоростью полового созревания, другими биологическими особенностями. Для выращивания осетровых в условиях индустриальных хозяйств с замкнутым циклом водоснабжения необходимо подбирать виды, отвечающие конкретным целям эксплуатации рыбоводного предприятия.
В данном материале приведены результаты сравнительного анализа морфометрические и рыбоводные показателей роста молоди осетровых рыб: белуга, стерлядь, русский осетр, шип в условиях регулируемых систем (УЗВ)
Факторы риска для агросистемы пастбищных земель ЗАПАДНО-КАЗАХСТАНСКОЙ ОБЛАСТИ РЕСПУБЛИКИ КАЗАХСТАН
Authors: Умбеткалиев Н.М. , Ожанов Г.С 
Published: September 2023

В статье исследуются проблемы деградации пастбищных угодий Западно-Казахстанской области. Рассмотрены вопросы состояние пастбищных земель в мире, Казахстане и Западно-Казахстанской области. Дана характеристика состояния пастбищных угодий в Западно-Казахстанской области. Проанализирована методика изучения уровня деградации пастбищных угодий, классификация пастбищ по уровню деградации. Подробно рассмотрены причины разрушения агросистемы почвенного покрова, сделаны выводы и даны предложения по улучшению состояния пастбищных угодий.
В Республике Казахстан около 41% населения страны (7,8 млн. человек) живут в сельских районах и большинство из них зависят от доходов, напрямую или косвенно связанных с аграрным сектором. Согласно приведенной статистике в Республике Казахстан по культуртехническому состоянию, в результате разрушения агросистемы почвенного покрова, 38,5% пастбищ относятся к деградированным в разной степени пастбищам.
К основным причинам разрушения агросистемы почвенного покрова были отнесены: бесконтрольный выпас скота, неправильная обработка и орошение почвы, чрезмерное применение химических удобрений, загрязнение и захламление пастбищ, неиспользования системы пастбищеоборотов, отсутствие работ по улучшению пастбищ. Большей частью данные причины влияют на экосистему пастбищ совместно, имеют кумулятивный эффект и приводят к ускоренной деградации пастбищ.