bluuebunny/crossref_metadata_2025_split huggingface dataset:
Collagen Nanofiber‐Lignin Composite Sponges with Adjustable Hierarchical Pore Structure for Efficient Low‐Frequency Sound Absorption
Authors: Ma Yan , He Mu , Wang Jiaxuan , Ma Fuying , Yu Hongbo , Zhou Yaxian , Xie Shangxian 
Published: January 2025

AbstractCurrent sound‐absorbing materials, reliant on nonrenewable resources, pose sustainability and disposal challenges. This study introduces a novel collagen‐lignin sponge (CLS), a renewable biomass‐based material that combines collagen's acoustic properties with lignin's structural benefits. CLSs demonstrate high porosity (>0.97), lightweight (10 mg cm−3), and exceptional broadband noise absorption performance (sound absorption coefficient exceeding 0.9 across 2000–6300 Hz). Due to their unique hierarchical and aligned pore structure, CLSs display superior low‐frequency sound‐absorbing capabilities and a high noise‐reduction coefficient of 0.64 (for a 30‐mm‐thick sample). A geometric model is also developed to evaluate and predict the sound absorption performance with high consistency to the experimental results. Additionally, the inclusion of lignin as a green crosslinker has significantly improved the thermal stability and compressive strength by ≈600% compared to collagen sponges alone. The innovative integration of collagen and lignin in this study not only leverages the benefits of renewable resources but also presents a cost‐effective and straightforward preparation process, positioning CLS as a promising alternative for the construction of sound‐absorbing materials seeking sustainable solutions.
A Peptide‐Derived Aggregation‐Induced Emission Nanobioprobe: Unlocking Selective Detection of Fusobacterium nucleatum and Noninvasive Screening of Colorectal Cancer
Authors: Liu Hongyu , Wu Tengling , Yu Yunjian , Xin Youtao , Lu Hegang , Zhao Shengke , Su Meihui , Ga Lu , Dong Alideertu , Elsabahy Mahmoud , Gao Hui 
Published: January 2025

ABSTRACTColorectal cancer (CRC) screening and early diagnosis is an effective strategy for reducing CRC mortality. However, the current detection methods involve exorbitant costs and complex procedures, which are inconvenient for large‐scale screening. Given its high prevalence in malignant tissues and feces of CRC patients, Fusobacterium nucleatum (F. nucleatum) has emerged as a crucial biomarker for the early detection of CRC. Herein, we propose an F. nucleatum‐specific recognition strategy for CRC screening and diagnosis. A novel nanobioprobe (AIE‐Pep) with aggregation‐induced emission (AIE) characteristics was synthesized by conjugating a red/near‐infrared (NIR) emissive AIE luminogen (AIEgen) with a FadA‐targeting peptide (ASANWTIQYND). The robust binding affinity between the peptide and FadA on F. nucleatum allows AIE‐Pep NPs to adhere selectively to F. nucleatum, and emits strong red/NIR fluorescence. In the model of the orthotopic CRC, AIE‐Pep NPs can precisely localize F. nucleatum around CRC. Moreover, AIE‐Pep NPs demonstrated a limit of detection (LOD) of 82.97 CFU/mL for F. nucleatum, which could significantly differentiate the feces of CRC mice from those of normal mice. Overall, this study presents a pivotal approach to specifically identifying F. nucleatum and holds immense potential for CRC diagnosis.
Could Better‐Quality Employment Improve Population Health? Findings From a Scoping Review of Multi‐Dimensional Employment Quality Research and a Proposed Research Direction
Authors: Ahonen Emily Q. , Winkler Megan R. , Bosmans Kim , Gunn Virginia , Julià Mireia 
Published: January 2025

ABSTRACTBackgroundPrecarious employment, a specific part of the conceptual spectrum of employment quality (EQ), has been established as an important risk to individual and population health and well‐being when compared to a standard employment circumstance. There remains a need, however, to explore whether and how EQ might be used as a tool to not only protect but also advance population health and well‐being.MethodsThe purposes of this scoping review were to assess the analytic treatment of the multiple dimensions of EQ and the stances researchers take to characterize the state of knowledge of EQ that supports the idea that better EQ is a health‐promoting factor. Quantitative, qualitative, and mixed‐methods primary studies that included at least three of the seven conceptually‐informed EQ dimensions were eligible. Studies were assessed for EQ dimensions represented, how dimensions were treated analytically, the pathogenic, ambivalent, or salutogenic stances used by investigators, and what each might tell us about how to leverage aspects of better‐quality employment to improve population health.ResultsA total of 78 studies were included; 54 of these treated EQ dimensions in an interrelated way. Of the analytically interrelated studies, none had an explicit salutogenic stance. Some evidence suggests that a handful of EQ types might present an equal or reduced risk of poor health than the standard employment relationship, frequently used as a historic gold standard.ConclusionResearch with a salutogenic stance might build our understanding of whether and how employment could be used to advance our collective well‐being.
Stabilizing Contorted Doubly‐Reduced Tetraphenylene with Heavy Alkali Metal Complexation: Crystallographic and Theoretical Evidence
Authors: Zhu Yikun , Zhou Zheng , Wei Zheng , Tsybizova Alexandra , Gershoni‐Poranne Renana , Petrukhina Marina A. 
Published: January 2025

AbstractThe two‐fold reduction of tetrabenzo[a,c,e,g]cyclooctatetraene (TBCOT, or tetraphenylene, 1) with K, Rb, and Cs metals reveals a distinctive core transformation pathway: a newly formed C−C bond converts the central eight‐membered ring into a twisted core with two fused five‐membered rings. This C−C bond of 1.589(3)–1.606(6) Å falls into a single σ‐bond range and generates two perpendicular π‐surfaces with dihedral angles of 110.3(9)°–117.4(1)° in the 1TR2− dianions. As a result, the highly contorted 1TR2− ligand exhibits a “butterfly” shape and could provide different coordination sites for metal‐ion binding. The K‐induced reduction of 1 in THF affords a polymeric product with low solubility, namely [{K+(THF)}2(1TR2−)] (K2‐1TR2−). The use of a secondary ligand facilitates the isolation of discrete complexes with heavy alkali metals, [Rb+(18‐crown‐6)]2[1TR2−] (Rb2‐1TR2−) and [Cs+(18‐crown‐6)]2[1TR2−] (Cs2‐1TR2−). Both internal and external coordination are observed in K2‐1TR2−, while the bulky 18‐crown‐6 ligand only allows external metal binding in Rb2‐1TR2− and Cs2‐1TR2−. The reversibility of the two‐fold reduction and bond rearrangement is demonstrated by NMR spectroscopy. Computational analysis shows that the heavier alkali metals enable effective charge transfer from the 1TR2−TBCOT dianion, however, the aromaticity of the polycyclic ligand remains largely unaffected.
Evaluation of Annual Storage on Online Released Compounds in Artemisia argyi Smoke With GC‐MS‐Based Untargeted Metabolomics Coupled With Chemometric Method of AntDAS‐GCMS
Authors: Zhai Meng , Liu Jia‐Nan , Wang Long‐He , Wen Yan‐Jin , Ma Hui , Liu Ping‐Ping , Chai Guo‐Bi , Zhang Qi‐Dong , Ma Ji , Yu Yong‐Jie 
Published: January 2025

ABSTRACTArtemisia argyi smoke, generated from the combustion of A. argyi, is widely utilized in traditional Chinese medicine for moxibustion and fumigation therapies. The released smoke during the combustion of A. argyi is rich in massive compounds and can be affected by storing periods. However, there is a lack of a comprehensive understanding on the chemical composition of released smoke, and the effects of annual storage on the released smoke were still unclear. Herein, a strategy that integrated chromatography–mass spectrometry (GC‐MS) with advanced chemometric software, AntDAS‐GCMS, was developed for comprehensively characterizing tens of compound in the released smoke of A. argyi and evaluating the quality variation across annual storage periods. Both particle and gas phases of the released smoke during the combustion were collected for GC‐MS analysis; the raw data files were then imported to our recently developed data analysis software AntDAS‐GCMS for automatically retrieving underlying components. Components that show significant difference among annual storage periods were screened to provide a total of 471 components. Finally, 61 compounds were identified. Both supervised and unsupervised chemometric methods suggest that the 2‐ and 4‐year storage periods were close to clinic used sample (3‐year storage), whereas a too short storage (like 1 year) or too long storage (6 years) were quite different from the 3‐year storage samples. In conclusion, this strategy provides a novel solution for evaluating smoke samples from traditional Chinese medicine.
Rapid and low‐temperature synthesis of MoAlB MAB phase by using stress‐induced Al‐particles
Authors: Dey Maharshi , Tran Quan , Zhang Jin , Ngige Godswill , Javaid Sabah , Pantoya Michelle , Gupta Surojit 
Published: January 2025

AbstractCurrently, MoAlB particles are produced at 1000°C and higher temperatures. In this manuscript, we report the rapid synthesis of MoAlB by altering the stress of Al particles to affect Al reactivity. The Al particles were purposefully stress‐altered to reduce their threshold for reaction. The stress‐altering process consisted of annealing followed by quenching of the aluminum powder. The combined process caused a reaction at a lower temperature between Mo, B, and Al to form MoAlB. The stress‐altering of Al particles (i.e., Al [TT‐treated]) was effective in producing >95 wt.% MoAlB after reaction at only 700°C for 10 min, a significant reduction in temperature. Based on these results, we can further project that this process can be used for manufacturing Al‐based compositions at significantly lower temperatures.
On‐Demand Continuous Flow Synthesis of Pentafluorosulfanyl Chloride (SF5Cl) Using a Custom‐Made Stirring Packed‐Bed Reactor
Authors: Peyrical Lauriane C. , Mabit Thibaud , Kairouz Vanessa , Charette André B. 
Published: January 2025

AbstractThe pentafluorosulfanyl (SF5−) group has been the subject of a surge of interest in the past decade, but there is still little practicality associated with its synthesis and installation. Herein is reported the first continuous flow synthesis of pentafluorosulfanyl chloride (SF5Cl), the most common reagent for the synthesis of SF5‐substituted compounds. The synthesis is based on inexpensive and easy‐to‐handle reagents: sulfur powder (S8), trichloroisocyanuric acid (TCCA) and potassium fluoride (KF). To this end, a custom‐made stirring reactor was designed to allow for fast, safe, and highly efficient on‐demand synthesis of SF5Cl. The resulting SF5Cl solution is showcased in the radical addition on alkynes in a telescoped fashion.
Oligoethylene Phosphoramidate‐Based Kinase Inhibitor Prodrugs – Solubility, Enzyme Inhibition, and Hydrolysis
Authors: Spiewok Sarah , Schaefer Maximilian , Lamla Markus , Jaritz Yannick , Kuehne Alexander J. C. 
Published: January 2025

AbstractThe efficiency of kinase inhibiting cancer therapeutics is often limited by their poor solubility in water. PEGylation is one possible strategy to improve the solubility of the drug, however, means to cleave off the PEG after reaching the target is important to make use of the therapeutic effects of the native drug. Moreover, the length of the PEG chains will have an effect on the solubility and binding. In this study, we want to extend our understanding of solubilizing oligo ethylene glycol (OEG) chains connected to kinase inhibitors using a pH labile phosphoramidate linker. We synthesize a library of drug‐OEG conjugates for Ceritinib, Crizotinib, Palbociclib, and Ribocilib kinase inhibitors with n=2, 3, 4 and 8 OEG repeat units. We study the influence on water solubility, enzyme inhibition, and pH induced hydrolysis. A maximum in solubility is obtained for n=3 or 4. We show that small differences in chain length can strongly influence the water solubility, while all other properties remain relatively comparable.
Resorcinol‐based Bolaamphiphilic Quaternary Ammonium Compounds
Authors: Asante Johanna Y. D. , Casey Caroline M. , Bezold Elise L. , Fernando Asantha , McDonough Diana , Wuest William M. , Minbiole Kevin P. C. 
Published: January 2025

AbstractQuaternary ammonium compounds (QACs) play crucial disinfectant roles in healthcare, industry, and domestic settings. Most commercially utilized QACs like benzalkonium chloride have a common architectural theme, leading to a rise in bacterial resistance and urgent need for novel structural classes. Some potent QACs such as chlorhexidine (CHX) and octenidine (OCT) feature a bolaamphiphilic architecture, comprised of two cationic centers at the molecular periphery and a non‐polar region connecting them; these compounds show promise to elude bacterial resistance mechanisms. Inspired by such structures, we synthesized a series of 43 biscationic amphiphilic compounds focused on a resorcinol core, featuring flexibility of linker lengths, alkyl tails, and relative substituent positioning, to study their structure activity relationships (SARs). Antibacterial activity evaluation against a panel of gram‐positive and gram‐negative strains, including ESKAPE pathogens (A. baumannii, P. aeruginosa), were encouraging, with minimum inhibitory concentrations (MICs) of 0.5–4 μM against all tested strains for select compounds. Ten prepared compounds bearing either 17 or 18 total side chain carbons demonstrated uniformly strong antibacterial activity against P. aeruginosa (MIC 4–16 μM) and 6 other strains (MIC ≤4 μM), irrespective of cationic spacing. These findings promise to further extend the application of bolaamphiphilic QACs as a novel class of disinfectants.
Post‐endoscopic sphincterotomy delayed bleeding occurs in patients with just 1‐day interruption of direct oral anticoagulants or hemodialysis
Authors: Hasegawa Sho , Kurita Yusuke , Yamazaki Yuma , Nihei Shinichi , Iizuka Takeshi , Misawa Noboru , Hosono Kunihiro , Endo Itaru , Kobayashi Noritoshi , Kubota Kensuke , Nakajima Atsushi 
Published: January 2025

AbstractObjectiveEndoscopic sphincterotomy (EST), especially when anticoagulants are used, carries a significant risk of delayed bleeding. However, the relationship between the use of antithrombotic agents, including direct oral anticoagulants, and post‐EST bleeding remains unclear. This study aimed to identify the risk factors for post‐EST delayed bleeding when antithrombotic agents were administered according to the guidelines.MethodsWe analyzed cases of patients who underwent endoscopic retrograde cholangiopancreatography and EST between January 2018 and August 2022, focusing on those with normal anatomy and naïve papillae. We examined the incidence of post‐EST bleeding, endoscopic retrograde cholangiopancreatography procedure details, severity and timing of post‐EST delayed bleeding, hemostatic interventions, and factors related to post‐EST delayed bleeding.ResultsAmong the 502 patients included, 76 (15%) were taking antithrombotic agents. Post‐endoscopic retrograde cholangiopancreatography delayed bleeding was noted in seven patients (1.4%). Mild, moderate, and severe delayed bleeding occurred in four, one, and two cases, respectively. Hemostatic injection completely controlled cases of delayed bleeding. Multivariate analysis identified a 1‐day direct oral anticoagulants interruption (odds ratio: 20.5, 95% confidence interval: 3.33–125, p = 0.0011) and dialysis (odds ratio: 38.7, 95% confidence interval: 2.4–624, p = 0.0099) as significant risk factors for delayed bleeding. No thromboembolic events related to the discontinuation of antithrombotic drugs were observed.ConclusionA 1‐day direct oral anticoagulants interruption and dialysis are independent risk factors for post‐EST delayed bleeding, necessitating careful consideration.
ApoE Genotype, Age, and Cognitive Decline in Old Chinese Individuals Without Dementia: A Population‐Based Study With Five‐Year Follow‐Up
Authors: Wu Hao , Gu Xingzhong , Liu Shuai , Wang Pan , Lu Hui , Guan Yalin , Shi Zhihong , Ji Yong 
Published: January 2025

ABSTRACTBackgroundApolipoprotein E (ApoE) ε4 genotype is a well‐known risk factor for Alzheimer's disease (AD). However, its effect on predicting cognitive decline in individuals without dementia and its association with age are unclear.ObjectiveTo investigate the relationship between ApoE polymorphism and risk of cognitive decline and dementia incidence in the elderly without dementia.MethodsThis population‐based prospective study was conducted between 2011 and 2016. The study involved 767 dementia‐free individuals who had undergone ApoE genotype analysis, were aged ≥ 60 years, and lived in rural China. Participants were divided into three ApoE groups: E3 (genotype 3/3), E4 (genotypes 3/4 and 4/4), and E2 (genotype 2/3) groups.ResultsAfter 5 years, 666 (86.8%) individuals were followed up. The rate of change in MMSE score was faster in the E4 group than in the E3 and E2 groups (5.0 ± 4.4 vs. 3.5 ± 3.8 vs. 3.9 ± 3.9, p = 0.001), after adjusting for age, sex, educational level and baseline MMSE scores, especially in the 70–79 years age group. In the same age group, the incidence rate of dementia was higher in the E4 group than in the E3 group (OR = 2.850; 95% CI: 1.146–7.090). After adjusting for age, sex, hypertensive status, educational level, marital status, engagement in social activities, and past history of stroke, the ApoE ε4 allele remained an independent risk factor for dementia incidence (OR = 3.070; 95% CI: 1.162–8.110) in individuals aged 70–79 years after follow‐up.ConclusionsApoE ε4 carriers with age ≥ 60 years had faster cognitive decline. The ApoE ε4 allele was an independent risk factor for dementia incidence in extremely old individuals.
The Effects of Glucagon‐Like Peptide‐1 Receptor Agonists on Mitochondrial Function Within Skeletal Muscle: A Systematic Review
Authors: Old Victoria J. , Davies Melanie J. , Papamargaritis Dimitris , Choudhary Pratik , Watson Emma L. 
Published: January 2025

ABSTRACTBackgroundObesity is a chronic disease associated with increased risk of multiple metabolic and mental health–related comorbidities. Recent advances in obesity pharmacotherapy, particularly with glucagon‐like peptide‐1 (GLP‐1) receptor agonists (RAs), have the potential to transform obesity and type 2 diabetes mellitus (T2DM) care by promoting marked weight loss, improving glycaemic control and addressing multiple obesity‐related comorbidities, with added cardio‐renal benefits. Dual agonists combining GLP‐1 with other enteropancreatic hormones such as glucose‐dependent insulinotropic polypeptide (GIP) have also been developed in recent years, leading to greater weight loss than using GLP‐1 RAs alone. However, up to 40% of the weight lost with GLP‐1 RAs comes from lean body mass, raising concerns about potential adverse effects on skeletal muscle function. Mitochondrial dysfunction, characterized by reduced mitochondrial size and activity, is prevalent in individuals with obesity and T2DM and is a known contributor to muscle wasting in ageing and some chronic diseases. This systematic review investigates the impact of GLP‐1‐based therapies on skeletal muscle mitochondrial function in individuals with obesity and T2DM or in related animal and cell models.MethodsA comprehensive search of MEDLINE, Scopus, CINAHL and clinicaltrials.gov was conducted. Inclusion criteria included randomized controlled trials, randomized crossover trials, cluster randomized control trials and basic science studies involving any GLP‐1 RA or GLP‐1/GIP dual agonist. Outcomes of interest were skeletal muscle respiratory function either in the form of measurements of mass, number, content, oxidative capacity/respiratory function, mitochondrial dynamics, mitochondrial biogenesis and mitophagy.ResultsEight studies were eligible for analysis; no human studies were identified. All of the included studies used GLP‐1 RAs (single agonists) as intervention. The emerging evidence suggests that GLP‐1 RAs increase mitochondrial area, number and morphology (i.e., reduces swelling). Data are conflicting on the effect of GLP‐1 RAs upon mitochondrial mass, respiration and the expression of uncoupling proteins and PGC‐1α. Data also demonstrate muscle specific (i.e., soleus vs. extensor digitorum longus) responses to GLP‐1 RAs.ConclusionGLP‐1 RAs appear to have a positive effect upon mitochondria area, number and morphology, but effects upon other aspects of mitochondrial health remain inconclusive. Data are very limited and solely presented in animal and in vitro models. Future studies should be conducted in human populations in order to begin to understand the effect of GLP‐1 RAs and GLP‐1‐based therapies on human skeletal muscle mitochondria.
Blood flow restriction‐enhanced platelet‐rich plasma: A pilot randomised controlled trial protocol
Authors: Ayyan Muhammad , Alladaboina Sushanth , Al‐Dolaymi Ayyoub , Boudier‐Revéret Mathieu , Papakostas Emmanouil , Marín Fermín Theodorakys 
Published: January 2025

ABSTRACTPurposeTo assess platelet‐rich plasma (PRP) changes in platelet and leucocyte count, insulin‐like growth factor 1 (IGF‐1), and interleukin 6 (IL‐6) concentration after bilateral low‐load knee extensions under blood flow restriction (BFR).MethodsThe present randomised controlled trial protocol will include two groups: the intervention group, which will undergo bilateral knee extensions under BFR, and the control group, which will perform bilateral knee extensions without BFR. Participants will be randomly allocated in a 1:1 ratio. Twenty‐two healthy individuals will be enrolled if the predefined inclusion criteria are met: (1) males, (2) ages 18–40, (3) Tegner activity level ≥5 and (4) with no musculoskeletal conditions that would interfere with exercise. Exclusion criteria include (1) individuals with systemic inflammatory diseases, (2) cardiovascular risk factors, (3) any blood dyscrasia, (4) Tegner Activity scale scores <5, (5) under nonsteroidal anti‐inflammatory drugs and aspirin treatment within one week before testing or (6) that had previously performed exercises on the testing day. The participant will perform low‐load bilateral knee extensions under BFR following a standard protocol of 30‐15‐15‐15 repetitions of consecutive sets with 30‐s rest intervals at 80% of limb occlusive pressure and 30% of 1‐RM load. PRP platelet and leucocyte count, IGF‐1 and IL‐6 concentration measurements (via flow cytometry, chemiluminescence testing and immunochromatography, respectively) will be conducted before exercise and 10, 20 and 30 min after the intervention.ResultsThe expected outcome is that the standard protocol of low‐load bilateral knee extensions under BFR will increase the platelet and leucocyte count, IGF‐1 and IL‐6 in the PRP preparation.ConclusionThe current protocol allows the study of an enhanced PRP formulation for its potential implementation in multiple sports injuries.