bluuebunny/crossref_metadata_2025_split huggingface dataset:
Structural characters of biaxially stretched polypropylene films and the relevant electrical insulating properties
Authors: Zeng Sixue , Li Quan , Liu Huixuan , Wang Jinqing , Wang Ke 
Published: May 2023

Abstract
Capacitor films from biaxially oriented polypropylene (BOPP) involve intensive external stress field, resulting in special crystallization and orientation characters. However, it still remains ambiguous on the relationship between crystallized morphology in BOPP bulk film and electric properties. In this work, two stretching modes, simultaneously biaxial stretching and sequentially biaxial stretching, were chosen to adjust film thickness, extended chain crystal content, fibrillar morphology, and orientation texture. Meanwhile, the working rules of these structural issues on electrical insulating properties were inspected. It reveals that extended chain crystals with thermal stability and isotropous fibrillated network favor to improved breakdown strength and lowered dielectric loss. These results offer good understanding on the processing-structure-property relation of polymer film dielectrics.
Peritoneal regression grading score (PRGS): first evidence for independent predictive and prognostic significance
Authors: Baake Janina , Nadiradze Giorgi , Archid Rami , Königsrainer Alfred , Bösmüller Hans , Reymond Marc , Solass Wiebke 
Published: May 2023

Abstract

Objectives
The peritoneal regression grading score (PRGS) is a four-tied pathologic score measuring tumor regression in biopsies from patients with peritoneal metastasis (PM) receiving chemotherapy.

Methods
This retrospective analysis of a prospective registry (NCT03210298) analyses 97 patients with isolated PM under palliative chemotherapy. We examined the predictive value of the initial PRGS for overall survival (OS) and the prognostic value of PRGS in repeated peritoneal biopsies.

Results
The 36 (37.1 %) patients with an initial mean PRGS≤2 had a longer median OS (12.1 months, CI 95 % 7.8–16.4) vs. 8.0 months (CI 95 % 5.1–10.8 months) in 61 (62.9 %) patients with PRGS≥3 (p=0.02) After stratification, the initial PRGS was an independent predictor of OS (Cox-regression, p<0.05). Out of 62 patients receiving≥two chemotherapy cycles, 42 (67.7 %) had a histological response (defined as a lower or stable mean PRGS in successive therapy cycles), and 20 (32.3 %) progressed (defined as an increasing mean PRGS). PRGS response was associated with a longer median OS (14.6 months, CI 5–95 % 6.0–23.2) vs. 6.9 (CI 5–95 % 0.0–15.9) months. PRGS response was prognostic in the univariate analysis (p=0.017). Thus, PRGS had both a predictive and prognostic significance in patients with isolated PM receiving palliative chemotherapy in this patient cohort.

Conclusions
This is the first evidence for the independent predictive and prognostic significance of PRGS in PM. These encouraging results need validation in an adequately powered, prospective study.
Comunicación política y redes sociales: análisis de la comunicación en Instagram de la campaña electoral del 13F
Authors: Moreno Cabanillas Andrea , Castillero Ostio Elizabet 
Published: May 2023

Gracias a la espectacularización que vive hoy en día la esfera política, las redes sociales han alcanzado una importancia inevitable en el desarrollo de campañas electorales. Estas plataformas se consolidan como herramientas partidistas de lo que se conoce como marketing político. Instagram se afianza cada vez más como canal de comunicación de los partidos políticos y dirigentes con su público, a través de la gestión estratégica fotografía-texto. Esta investigación persigue comprender la manera en la que emplean los candidatos a la presidencia de Castilla y León con mayor número de votos la red social para la construcción de su propia marca personal, durante la campaña electoral de las pasadas elecciones del día 13 de febrero. La metodología seguida es el análisis de contenido, aplicando una hoja estandarizada a cada una de las publicaciones del perfil de Instagram de los líderes políticos del PP, PSOE, Ciudadanos, Podemos, Vox y UPL. Se centra en las publicaciones de sus perfiles de Instagram, en términos de contenido y de imagen y videos, dando a conocer las diferencias y similitudes entre cada partido. En total se analizan 132 publicaciones compartidas entre los días 28 de enero y 13 de febrero de 2022. La principal conclusión extraída es que no existe un patrón consolidado sobre el uso de la plataforma para la imagen personal. Si bien es cierto que formaciones políticas creadas en los últimos años llevan a cabo una mejor gestión estratégica de la comunicación utilizando las nuevas funcionalidades de la red social.
Transcriptional response of endometrial cells to insulin, cultured using microfluidics
Authors: Young Baik Soo , Maini Alisha , Tinning Haidee , Wang Dapeng , Adlam Daman J , Ruane Peter T , Forde Niamh 
Published: May 2023

Obesity is a rapidly growing public health issue among women of reproductive age associated with decreased reproductive function including implantation failure. This can result from a myriad of factors including impaired gametes and endometrial dysfunction. The mechanisms of how obesity-related hyperinsulinaemia disrupts endometrial function are poorly understood. We investigated potential mechanisms by which insulin alters endometrial transcript expression. Ishikawa cells were seeded into a microfluidics device attached to a syringe pump to deliver a constant flow rate of 1 µL/min of the following: (i) control (ii) vehicle control (acidified PBS), or (iii) insulin (10 ng/mL) for 24 h (n = 3 biological replicates). Insulin-induced transcriptomic response of endometrial epithelial cells was determined via RNA sequencing, and DAVID and Webgestalt to identify Gene Ontology (GO) terms and signalling pathways. A total of 29 transcripts showed differential expression levels across two comparison groups (control vs vehicle control; vehicle control vs insulin). Nine transcripts were differentially expressed in vehicle control vs insulin comparison (P < 0.05). Functional annotation analysis of transcripts altered by insulin (n = 9) identified three significantly enriched GO terms: SRP-dependent co-translational protein targeting to membrane, poly(A) binding, and RNA binding (P < 0.05). The overrepresentation analysis found three significantly enriched signalling pathways relating to insulin-induced transcriptomic response: protein export, glutathione metabolism, and ribosome pathways (P < 0.05). Transfection of siRNA for RAPSN successfully knocked down expression (P < 0.05), but this did not have any effect on cellular morphology. Insulin-induced dysregulation of biological functions and pathways highlights potential mechanisms by which high insulin concentrations within maternal circulation may perturb endometrial receptivity.

Lay summary
Changes in components of blood associated with obesity in women of reproductive age can have consequences for pregnancy success. These changes to circulating molecules associated with obesity can alter the ability of the endometrium (the innermost lining of the womb/uterus) to be receptive to an embryo to implant – a key stage of successful pregnancy. Understanding which molecules contribute to this is difficult and one in particular, insulin, can change the role of the endometrium. Studying this is limited to static culture, that is, the cells are not exposed to sustained and high concentrations of Insulin that could occur in the mother. In this study, we use a new laboratory-based approach (microfluidics) that allows us to mimic maternal circulation. We have determined that exposure of these endometrial cells to insulin changes the expression of specific genes that may lead to the inability of the endometrium to support implantation and early pregnancy.
Dominant follicle growth patterns and associated endocrine dynamics in anovulatory and ovulatory waves in women
Authors: Bashir Shah T , Baerwald Angela R , Gastal Melba O , Pierson Roger A , Gastal Eduardo L 
Published: May 2023

Growth patterns and associated endocrine profiles were compared between dominant anovulatory (ADF) and ovulatory follicles (OvF) developing from different waves within and between menstrual cycles in women. Follicular mapping profiles of 49 healthy women of reproductive age and blood samples were obtained every 1–3 days during one interovulatory interval. Sixty-three dominant follicles were classified into wave 1 (W1ADF; n = 8) and wave 2 (W2ADF; n = 6) anovulatory follicles and wave 2 (W2OvF; n = 33) and wave 3 (W3OvF; n = 16) ovulatory follicles. Comparisons were made between W1ADF and W2ADF, W2ADF and W2OvF, and W2OvF and W3OvF. The waves were numbered 1, 2, or 3 based on when the waves emerged relative to the preceding ovulation. W1ADF emerged closer to the preceding ovulation, and W2ADF emerged in the late luteal or early follicular phase. The interval from emergence to maximum diameter was shorter for W2ADF than W1ADF and for W3OvF than W2OvF. Selection of W3OvF occurred at a smaller diameter compared to W2OvF. W1ADF regressed at a faster rate than W2ADF. Also, W1ADF were associated with lower mean follicle stimulating hormone (FSH) and higher mean estradiol than W2ADF. In contrast, W3OvF were associated with higher FSH and luteinizing hormone (LH) compared to W2OvF. However, W2OvF were associated with higher progesterone than W3OvF. This study contributes to the understanding of the physiologic mechanisms underlying selection of the dominant follicle, ovulation, and pathophysiology of anovulation in women, as well as optimization of ovarian stimulation protocols for assisted reproduction.

Lay summary
Ovarian follicles (the fluid-filled sacs that contain the eggs) develop within 2 or 3 waves during the human menstrual cycle. Typically, only one follicle in each cycle releases an egg during ovulation. The rest of the follicles grow then regress. In this study, we characterized differences in the growth, regression, and associated hormone production between follicles that ovulated and those that did not, developing from different waves within and between menstrual cycles. Differences regarding follicle growth patterns and hormone concentrations were found when comparing different waves and whether a follicle ovulated. Results from this study improve our understanding of the processes underlying follicular growth and ovulation, which in turn may assist in improving fertility and birth control treatments.
Family doctors’ and dentists’ access and dissemination of medical information through social media
Authors: Capraș Roxana Denisa , Cordoș Ariana-Anamaria , Călinici Tudor , Dumitrașcu Dinu Iuliu , Bolboacă Sorana D. 
Published: May 2023

Background: Across the globe it has been observed a high reluctance among doctors to engage with social media. The hereby research aims to analyze how physicians circulate medical information using social media. Material and method: The targeted sample population was represented by family physicians and dentists who during 2017 had a contract with the Romanian National Health Insurance House. From the website of the Romanian National Health Insurance House were collected the available e-mail addresses (8,497) and phone numbers (5,422). The call to complete in the research contained a link to the online questionnaire. The request to partake was sent via SMS, WhatsApp and / or e-mail from 24 May to 14 July 2017. For comparison purposes the responders were split in 3 age groups. Millennials were defined as below 38 years old. Generation X represented people between 38 and 51 years old. Baby Boomers were the group aged above 51 years old.
Results: The described methodology generated 120 valid questionnaires. The majority of them came from women (61%) living in urban areas (71%) working in private practices using Facebook (85%).
Generation X connect more to SM from public places as compared to Baby Boomers (p=0.007).
Doctors seek medical information on SM monthly (83%) but rarely give advice through SM to colleagues (28%) or contribute to patients’ medical education (32%).
Most physicians interact with their patients through SM (59%), but do not discuss with them about how to search for health information.
Conclusion: This research highlighted a low SM usage among Romanian physicians. As anticipated, doctor’s awareness of the SM’s versatile environment was strongly influenced by their age. While doctors acknowledged SM as a resource for medical information they did not engage in cultivating patient’s medical education through these platforms.
Influence of class A40 autonomous truck on rutting and fatigue cracking
Authors: Fahad Mohammad , Nagy Richard 
Published: May 2023

AbstractEffects of autonomous trucks' different lateral wander modes have been analyzed in this research using a dload subroutine. Two lateral wander modes, a zero-wander mode in which a truck is programmed to follow a predetermined wheel path without any lateral movement and a uniform wander mode, where the truck uniformly distributes itself along the lateral width of the lane, are used. European class A40 truck has been modeled in ABAQUS code. Results show that fatigue life of pavement increases by 1.45 times if a uniform wander mode is used, which corresponds to a decrease in fatigue life of 14 months if a zero-wander mode is used. In case of rutting progression, 40% acceleration of rutting happens under a zero-wander mode. In case of uniform wander mode, rut depth decreases by 1.25 times against the zero-wander mode.
Humorous Portrayals of Celebrities in the Mass Media During the 2021 Papal Visit to Slovakia
Authors: Polievková Petra , Rončáková Terézia , Tkáčová Hedviga 
Published: May 2023

This contribution presents the results of research focused on an analysis of humorous visual portrayals of visit of Pope Francis to Slovakia in September 2021. The study presents a qualitative content analysis of 43 memes taken from the social media environment and eight caricatures from selected print media outlets. The aim of the analysis of the memes and caricatures was to identify the topics that framed the papal visit before shifting the focus to the question of how the memes and caricatures present Pope Francis and selected Slovak political figures within this context. The study will identify the characteristics ascribed to the Pope and to Slovak politicians in the media and the tonalities (either positive, negative, or neutral) emphasized in the studied memes and caricatures in relation to the Pope, politicians, Slovak society, and the Church.
A retrospective study on efficacy and safety of copper T 380 A as a contraceptive method
Authors: Meena Chelle , Tatikunta Vijayakrishna , Neeli Karuna , Clara Roy Sharon 
Published: May 2023

: The copper T intrauterine contraceptive device (IUCD) is a widely used reversible contraceptive method all over the world today. They are effective and recommended for use up to 10 years. Intrauterine contraceptive device used as a spacing method in many couples. Some of the causes for removal include desire for pregnancy and sterilization etc. : To determine the efficacy of copper T(Cu T) 380 A as a contraceptive method. To determine the indications of discontinuation of Cu T 380 A. To identify the difficulties faced during removal in outpatient basis and cases which required removal under anaesthesia in operation theatre.: Retrospective analysis of Cu T removals done at Gandhi hospital, Secunderabad over 6 months duration, from December 2021 to May 2022. A total number of 128 cases were observed and included in this study.: Among the IUCD users, majority belonged to age group of 20 – 30 years. Most of the cases reported for removal came after 2-5 years of usage. Among them, most were referred from periphery in view of difficulty in removal, as Gandhi hospital is a tertiary care centre. Out of 128 cases of total Cu T removals, 68 cases(53.1%) were removed on outpatient basis, 60 cases (46.8%) were removed under anaesthesia. Major indication for removal was desire for pregnancy in 99 cases (77.3%), 26 (20.3%)cases were removed for sterilization, 1 (0.78%) case was removed for failure of contraception, 1 (0.78%)case for abnormal uterine bleeding and dysmenorrhea, 1 (0.78%) case for uterine perforation.: Copper T is an effective, safe, long-lasting, convenient reversible contraceptive method with very few side effects. The information in this study may be useful to counsel women who are considering the IUCD as a contraceptive method and current users who are requesting for removal due to side effects.
Emsella: A breakthrough, non invasive technology for treatment of incontinence
Authors: Singh Chanchal Kumar , Deshpande Juhi 
Published: May 2023

Emsella is a revolutionary, US FDA approved, noninvasive treatment technology used for treatment of urinary incontinence in both men and women. It uses High-Intensity Focused Electromagnetic (HIFEM) technology as well as biofeedback mechanism for this purpose. Emsella delivers around 11,000 Kegel’s contractions in half hour and strengthens the muscles so that patients can hold the bladder and urethra together tighter, providing control and strength.Other uses involve sexual rejuvenation, treatment of erectile dysfunction, prolapse, coccydynia.
Legislações e políticas públicas: um estudo comparado internacional em Educação Especial na Educação Superior
Authors: Hora Júnio , Bazilatto Alexandre , Pantaleão Edson 
Published: May 2023

O ensaio analisa legislações e políticas públicas para estudantes público-alvo da Educação Especial na Educação Superior, em contexto latino-americano entre México e Brasil. Para um estudo comparado, baseamo-nos na metodologia histórico-documental trabalhando legislações educacionais entre 1996 e 2018. A perspectiva teórica dos Processos Civilizadores, por Norbert Elias (1993; 1998; 2001; 2006; 2011), destacando um conjunto das relações entre indivíduos e grupos sociais para sua constituição, cujos processos de interdependência formam as figurações humanas e suas ações em paralelo aos Estados em que essas figurações compõem. Os dados demonstram que México e o Brasil contemplam legalmente o acesso de estudantes público-alvo da Educação Especial à Educação Superior. Questionamos sobre a aplicabilidade desses documentos e em que medida a não concretização impacta no Processo Civilizador e aprimoramento do respeito às diferenças.
Exploring vocational students' satisfaction with online learning
Authors: Rahyasih Yayah , Wijaya Widia Murni , Syarifah Liah Siti 
Published: May 2023

This study aimed to explore the factors that influence vocational students' perceptions of their online learning experiences and assess the quality of online learning that has an impact on student satisfaction. This research used structural equation modeling and partial least square (PLS-SEM) analysis. The purposive sampling technique was chosen to determine the sample of respondents. A total of 3206 students who participated in online learning from various vocational schools in Indonesia filled out an online survey. The results indicate that communication, digital media, interaction, facilities and tutorials have a direct effect on the quality of online learning. Schools that offer online education must prioritize the essential factors required for successful implementation to ensure that students have an enjoyable online learning experience. Teachers should focus on improving the quality of online learning to increase student satisfaction with it. Furthermore, teachers should consider the findings of this research when developing strategies for vocational education in online settings.
Inductions of memory-like B cells and plasma-like cells from human naïve B cells in hypoxic cultures
Authors: Tokumoto Yasuhito , Araki Yasuto , Narizuka Yusuke , Mizuno Yosuke , Ohshima Susumu , Mimura Toshihide 
Published: May 2023

Abstract
Recently, we induced memory-like T cells from human naïve T cells in a hypoxic culture. In this study, we attempted induction of both memory B cells and plasma cells from human naïve B cells in hypoxic cultures. Although the hypoxic culture (1% O2) did not support the survival of naïve B cells, it supported the survival of B cells that were activated by interleukin 4 (IL-4) and lipopolysaccharides (LPS). On activation culture Day 7, there was no survivor in 20% O2, but 29.5% of the activated B cells survived in 1% O2. Next, we withdrew both IL-4 and LPS from the B-cell culture preactivated for 7 days in 1% O2, and the culture was continued for another 7 days. As a result, 12.4% of the B cells survived. These memory-like B cells decreased in body size and number of cytoplasmic granules. Moreover, we tried to induce plasma-like cells. Human naïve B cells were activated by two-step culture for 9 days, after which all activators were withdrawn from the medium, and the cells were cultured for an additional 6 days in 1% O2. The viability was 0.2%, but over 92% of the survivors showed a CD20-/CD27+/CD38+ plasma cell phenotype.
Consumption of polypropylene by Galleria mellonella (Insecta, Lepidoptera, Pyralidae) larvae did not cause degenerative changes in internal organs
Authors: Rost-Roszkowska Magdalena , Mermer Patrycja , Chajec Łukasz , Sosinka Agnieszka , Wilczek Grażyna , Student Sebastian , Wrońska Anna , Karnówka Oskar 
Published: May 2023

Abstract
G. mellonella is a promising species for use in the biodegradation of plastics. It is easy to breed and has high resistance to diverse climatic conditions, which is particularly valuable when considering its potential application in the decomposition of plastics. Although it does not pose a direct threat to humans, the greater wax moth is a parasitic species in bee hives, contributing to the population decline of these insects. This species has demonstrated the capacity for biodegradation of the most common types of plastics, such as polyethylene and polypropylene (PP). The microbiome inhabiting the digestive system is responsible for this degradation. However, there reports on whether consumed plastics or their decomposition products will adversely affect the structure and functioning of the internal organs are rather poor. The aim of these studies was to determine whether the consumption of PP by a larger wax moth (G. mellonella) larvae caused any ultrastructural changes in the organs of the animal's body and to evaluate the survival rate of the animals and describe their reproduction. Thus, this study provided a preliminary understanding of histological and ultrastructural changes caused, or not caused, by the PP diet. We investigated whether any degenerative changes appeared in cells of selected organs – midgut, silk gland, and fat body – under PP consumption by G. mellonella caterpillars (7th instar larvae). We also examined whether there was an increase in levels of reactive oxygen species (ROS) in selected organs, as well as the ability of larvae to survive and undergo metamorphosis. The animals were divided into four groups: G0-C, G0-S, G0-24, and G0-48. The research was carried out using transmission electron microscopy (TEM), confocal microscopy, and flow cytometry. Our study on G. mellonella larvae fed with PP bags showed that a diet containing such plastic did not affect internal organs at the ultrastructural level. Cells in the analyzed organs – midgut, silk gland, and fat body – showed no degenerative changes. An increase in the intensity of autophagy and cell vacuolization was noted, but they probably act as a survival pathway. These observations suggest that the final larval stage of the greater wax moth can potentially be applied in PP biodegradation.