bluuebunny/crossref_metadata_2025_split huggingface dataset:
Seroprevalence of human toxocariasis in Latin America and the Caribbean: a systematic review and meta-analysis
Authors: Ulloque-Badaracco Juan R. , Hernandez-Bustamante Enrique A. , Alarcón-Braga Esteban A. , Huayta-Cortez Miguel , Carballo-Tello Ximena L. , Seminario-Amez Rosa A. , Rodríguez-Torres Alejandra , Casas-Patiño Donovan , Herrera-Añazco Percy , Benites-Zapata Vicente A. 
Published: June 2023

Introduction:The current study aimed to quantitatively synthesize available evidence regarding the seroprevalence of human toxocariasis in Latin America and the Caribbean.Methods:A systematic research involving six electronic databases was conducted using a research strategy that combined MeSH terms with free terms. Article selection and information extraction were performed using a double and independent approach. The Newcastle-Ottawa tool was used to assess the risk of bias in the included articles. The meta-analysis used the random-effects approach, with subgroup analysis and sensitivity analysis for risk of bias also being performed.Results:We included 101 articles with a total of 31,123 participants. The studies were conducted between 1990 and 2022, with Brazil accounting for the largest number of studies (n = 37). The overall seroprevalence of human toxocariasis was 31.0% (95% CI: 27.0-35.0%, I2 = 99%). The prevalence of the main characteristics observed in seropositive patients were as follows: ocular toxocariasis (30.0%), asymptomatic (26.0%), and presence of dogs at home (68.0%). In addition, the seroprevalence was lower in studies including only adults than in those including children or both. In contrast, no differences in seroprevalences were found between studies conducted in the community and hospital.Conclusion:The overall seroprevalence of human toxocariasis in Latin America and the Caribbean was high. Notably, our findings showed that the seroprevalence was increased among populations who kept a dog at home but was decreased in populations comprising only adults. Our findings can be used to establish epidemiological surveillance strategies for the prevention and early identification of toxocariasis.
The effectiveness of educational interventions in the community that aim to improve informal carers knowledge of dementia anatomy, physiology, progression, and impact on behavior: a systematic review
Authors: Bushell Dayna , Jones Cindy , Moro Christian 
Published: June 2023

IntroductionDementia education is a vital component of dementia care and management for patients and their informal carers and family. To fully understand dementia, some knowledge of the anatomy and physiology of the brain may be necessary and would help informal carers understand behaviors of dementia to help cope with care provision.MethodThis integrative review aims to identify, appraise, and assess whether dementia education resources include information detailing the anatomy of the brain and its relationship with dementia and whether this information improves knowledge (PROSPERO Registration Number: CRD42022320530). Literature published from 2012 until May 4, 2022 was searched in eight databases with six articles meeting the inclusion criteria.ResultsUsing the Mixed Methods Appraisal Tool (2018) methodological quality varied across studies. There are limited educational interventions which incorporate information on the anatomy and the physiology of the brain. None of the interventions focused solely on providing neurological education; however, all contained at least some content that addressed this, as per inclusion criteria. In most cases, the educational interventions were well-received and delivered, which did not differ, whether they were delivered in person or virtually. The majority of the studies reported an increase in dementia knowledge (measured pre-post or perceived) following the intervention.DiscussionEducational interventions on brain anatomy and physiology remain limited, and if included, are often not the focus, and as such more rigorous study is required to investigate the effect of educational interventions on dementia knowledge and their role in dementia care.
Perceptual video quality assessment: the journey continues!
Authors: Saha Avinab , Pentapati Sai Karthikey , Shang Zaixi , Pahwa Ramit , Chen Bowen , Gedik Hakan Emre , Mishra Sandeep , Bovik Alan C. 
Published: June 2023

Perceptual Video Quality Assessment (VQA) is one of the most fundamental and challenging problems in the field of Video Engineering. Along with video compression, it has become one of two dominant theoretical and algorithmic technologies in television streaming and social media. Over the last 2 decades, the volume of video traffic over the internet has grown exponentially, powered by rapid advancements in cloud services, faster video compression technologies, and increased access to high-speed, low-latency wireless internet connectivity. This has given rise to issues related to delivering extraordinary volumes of picture and video data to an increasingly sophisticated and demanding global audience. Consequently, developing algorithms to measure the quality of pictures and videos as perceived by humans has become increasingly critical since these algorithms can be used to perceptually optimize trade-offs between quality and bandwidth consumption. VQA models have evolved from algorithms developed for generic 2D videos to specialized algorithms explicitly designed for on-demand video streaming, user-generated content (UGC), virtual and augmented reality (VR and AR), cloud gaming, high dynamic range (HDR), and high frame rate (HFR) scenarios. Along the way, we also describe the advancement in algorithm design, beginning with traditional hand-crafted feature-based methods and finishing with current deep-learning models powering accurate VQA algorithms. We also discuss the evolution of Subjective Video Quality databases containing videos and human-annotated quality scores, which are the necessary tools to create, test, compare, and benchmark VQA algorithms. To finish, we discuss emerging trends in VQA algorithm design and general perspectives on the evolution of Video Quality Assessment in the foreseeable future.
The interactive medical simulation toolkit (iMSTK): an open source platform for surgical simulation
Authors: Moore Jacob , Scheirich Harald , Jadhav Shreeraj , Enquobahrie Andinet , Paniagua Beatriz , Wilson Andrew , Bray Aaron , Sankaranarayanan Ganesh , Clipp Rachel B. 
Published: June 2023

Introduction: Human error is one of the leading causes of medical error. It is estimated that human error leads to between 250,000 and 440,000 deaths each year. Medical simulation has been shown to improve the skills and confidence of clinicians and reduce medical errors. Surgical simulation is critical for training surgeons in complicated procedures and can be particularly effective in skill retention.Methods: The interactive Medical Simulation Toolkit (iMSTK) is an open source platform with position-based dynamics, continuous collision detection, smooth particle hydrodynamics, integrated haptics, and compatibility with Unity and Unreal, among others. iMSTK provides a wide range of real-time simulation capabilities with a flexible open-source license (Apache 2.0) that encourages adoption across the research and commercial simulation communities. iMSTK uses extended position-based dynamics and an established collision and constraint implementations to model biological tissues and their interactions with medical tools and other tissues.Results: The platform demonstrates performance, that is, compatible with real-time simulation that incorporates both visualization and haptics. iMSTK has been used in a variety of virtual simulations, including for laparoscopic hiatal hernia surgery, laparoscopic cholecystectomy, osteotomy procedures, and kidney biopsy procedures.Discussion: iMSTK currently supports building simulations for a wide range of surgical scenarios. Future work includes expanding Unity support to make it easier to use and improving the speed of the computation to allow for larger scenes and finer meshes for larger surgical procedures.
Microspatial distribution of trace elements in feline dental hard tissues: early life exposure to essential and toxic elements
Authors: Wright Alexandra L. , Fiani Nadine , Peralta Santiago , Arora Manish , Austin Christine 
Published: June 2023

IntroductionTrace elements play a key role in dental tissue development, as dental hard tissues accumulate both essential and toxic trace elements during mineralization. Characterization of the spatial accumulation pattern of trace elements may provide insight into exposure to toxic elements over time and to the nature of disease processes affecting the hard dental tissues. Here, we present the first report of the use of laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS) to map the microspatial distribution of multiple trace elements, essential and toxic, across feline dental hard tissues.MethodsEleven teeth were extracted from 8 cats. Nine teeth were from 7 cats diagnosed with idiopathic tooth resorption on intraoral radiographs prior to extraction. Two teeth were included from a cadaver that had no signs of tooth resorption on intraoral radiographs. The normal dental tissue was analyzed from each sample using LA-ICP-MS to map the microspatial distribution of essential and toxic trace elements across feline enamel, dentin, and cementum.ResultsResults showed a higher accumulation of barium and strontium in coronal dentin as compared to root dentin. The timing of the accumulation mirrors nursing timelines seen in teeth from human and non-human primates, consistent with barium and strontium being sourced from maternal milk. Results also showed a higher uptake of lead in the coronal dentin, suggesting this lead exposure was likely passed from mother to offspring.DiscussionThis work characterizes a baseline for elemental distribution in feline teeth linked to early life exposure to toxic elements such as lead and provides a framework for future studies investigating long-term environmental exposures to trace elements, essential and toxic, and their involvement in feline systemic and dental diseases.
Chronic HCV infection promotes cytotoxicity in antigen-specific CD8+ T cells regardless of virus specificity
Authors: Maretti-Mira Ana C. , Salomon Matthew P. , Hsu Angela M. , Matsuba Chikako , Golden-Mason Lucy 
Published: June 2023

IntroductionDespite advancements in hepatitis C virus (HCV) infection treatment, HCV still represents a significant public health burden. Besides progressive hepatic damage, viral persistence has lasting effects on innate and adaptive immune responses. Lack of a complete understanding of the factors driving an effective HCV response contributes to the failure to develop a vaccine for prevention. This study advances the existing knowledge on HCV-specific CD8+ T cells and describes the impact of current or past HCV infection on CD8+ T cells specific for other viruses.MethodsWe used barcoded-dextramers to identify and sort CD8+ T cells specific for HCV, cytomegalovirus, and influenza, and characterized them using single-cell RNA sequencing technology. Our cohort included chronic (cHCV), spontaneously resolved (rHCV), and subjects undergoing direct-acting antiviral (DAA) therapy.ResultsWe show that HCV-specific CD8+ T cells have cytotoxic features in patients with cHCV, which is progressively reduced with DAA therapy and persists 12 weeks after treatment completion. We also observe a shift in the CD8+ T cell phenotype on DAA treatment, with decreased effector memory and exhausted cell signatures. In rHCV, we also detected a smaller proportion of effector memory cells compared to cHCV. The proportion of CD8+ exhausted T cells in cHCV and rHCV subjects was comparable. Moreover, we also observed that non-HCV virus-specific CD8+ T cells exhibit robust cytotoxic traits during cHCV infection.DiscussionAltogether, our findings suggest that cHCV infection promotes cytotoxicity in CD8+ T cells regardless of virus specificity. The immunological changes caused by cHCV infection in CD8+ T cells may contribute to worsening the ongoing hepatic damage caused by HCV infection or exacerbate the immune response to possible co-infections. Our data provide a resource to groups exploring the underlying mechanisms of HCV-specific T cell spontaneous and treatment-induced resolution to inform the development of effective vaccines against HCV infection.
Fertility Life Table, Thermal Requirements, and Ecological Zoning of Anthonomus grandis grandis Boheman (Coleoptera: Curculionidae) in Brazil
Authors: Pereira Fernanda Polastre , Diniz Alexandre José Ferreira , Parra José Roberto Postali 
Published: June 2023

The boll weevil, Anthonomus grandis grandis Boh., is the most important cotton pest in Central and South America. The biological characteristics and thermal requirements of boll weevils reared on an artificial diet were assessed at seven constant temperatures (18, 20, 22, 25, 28, 30, and 32 ± 1 °C) under laboratory conditions. These data were used to determine the ecological zoning for the pest in Brazil. The development time; oviposition period; the number of eggs produced; survival of eggs, larvae, and pupae; adult longevity; and sex ratio were recorded, and additional life table parameters were calculated. The total development duration ranged from 16.1 (32 °C) to 46.2 (18 °C) days. Temperature significantly affected the number of eggs laid per female (fecundity), with the highest number of eggs observed at 25 °C (251 ± 15.8). The parameters from the fertility life table indicated the greatest population growth at 25 °C and 28 °C. The net reproductive rate (R0) at these temperatures was 22.25 times higher than at 18 °C. Based on R0 and temperature, an ecological zoning of the pest was developed for Brazil. Brazilian regions with mean temperatures above 20 °C and below 30 °C are most favorable for the population growth of the boll weevil. The most suitable crop areas were found to be the north, midwest, and part of the northeast region, although the weevil can occur throughout Brazil if the host plants are available.
A Refractive Index- and Density-Matched Liquid–Liquid System Developed Using a Novel Design of Experiments
Authors: Tang Jianxin , Wang Chenfeng , Liu Fei , Yang Xiaoxia , Wang Rijie 
Published: June 2023

Refractive index and density matching are essential for optical measurements of neutrally buoyant liquid–liquid flows. In this study, we proposed a design of experiments (DoE) to develop refractive index and density matching systems, including objective setting, candidates screening, sampling and fitting, and a detailed matching process. Candidates screening criteria based on the density and refractive index ranges of the aqueous and organic phases were used. Using the DoE, we proposed a system with a ternary aqueous phase potassium thiocyanate (KSCN)/ammonium thiocyanate (NH4SCN) solution and m-dichlorobenzene/tripropionin solution as the organic phase to achieve the tuning of the RI and density simultaneously. Empirical correlations of the refractive index and density with respect to the concentration and temperature for the three mixtures were obtained by combining Latin hypercube sampling with binary polynomial fitting. Correlations were validated with existing data in the literature and were found to align with deviations as low as 4×10−4 for the refractive index and 2×10−3 g⋅cm−3 for the density. Using the correlations, the refractive indices for the ternary aqueous phase, the binary organic phase, and the device materials were matched to be equal. Density matching was performed for the liquid–liquid phases as well. Refractive index- and density-matched recipes could be obtained for a wide range of temperatures (15–65 °C) and device materials (PMMA, borosilicate glass, quartz, and silica gel). These recipes provide options for the optical measurement of a liquid–liquid system required to neutralize buoyancy.
Low-Cost Online Monitoring System for the Etching Process in Fiber Optic Sensors by Computer Vision
Authors: Rodríguez-Rodríguez Wenceslao Eduardo , Puente-Sujo Jesús Abraham , Rodríguez-Rodríguez Adolfo Josué , Matias Ignacio R. , Vargas-Requena David Tomás , García-Garza Luis Antonio 
Published: June 2023

The present research exposes a novel methodology to manufacture fiber optic sensors following the etching process by Hydrofluoric Acid deposition through a real-time monitoring diameter measurement by computer vision. This is based on virtual instrumentation developed with the National Instruments® technology and a conventional digital microscope. Here, the system has been tested proving its feasibility by the SMS structure diameter reduction from its original diameter of 125 μ until approximately 42.5 μm. The results obtained have allowed us to demonstrate a stable state behavior of the developed system during the etching process through diameter measurement at three different structure sections. Therefore, this proposal will contribute to the etched fiber optic sensor development that requires reaching an enhanced sensitivity. Finally, to demonstrate the previously mentioned SMS without chemical corrosion, and the etched manufactured SMS, both have been applied as glucose concentration sensors.
ANALISIS STRUKTUR BATIN PUISI “DI BUTON UTARA OH KEKASIHKU” KARYA RIZAL WINATA
Authors: Muammar Muammar 
Published: June 2023

Struktur Batin Puisi “Di Buton Utara Oh Kekasihku” Karya Rizal Winata. Penelitian ini mengungkap bagaimanakah struktur batin puisi “Di Buton Utara Oh Kekasihku” Karya Rizal. Tujuan Penelitian ini adalah mendeskripsikan struktur batin puisi “Di Buton Utara Oh Kekasihku” Karya Rizal Winata. Metode yang digunakan dalam penelitian ini yaitu metode deskriptif kualitatif yaitu penggambaran atau penyajian data berdasarkan kenyataan-kenyataan secara objektif sesuai dengan objek penelitian, dengan cara menelaah secara seksama puisi yang diteliti. Jenis penelitian yang digunakan dalam penelitian ini adalah penelitian kepustakaan (library research) yaitu dengan cara mengadakan studi melalui bahan bacaan yang relevan serta mendukung penelitian ini. Data yang digunakan dalam penelitian ini adalah puisi “Di Buton Utara Oh Kekasihku”. Teknik pengumpulan data dalam penelitian ini yaitu baca catat. Hasil yang diperoleh dari penelitian terlihat bahwa tema puisi yaitu tentang Kerinduan pada kekasih, selanjutnya, perasaan dalam puisi ini mengungkap rasa penghormatan dan kerinduan. Nada dalam puisi ini menunjukkan tekad yang tinggi dan penuh semangat. Selanjutnya amanat yang dikandung puisi ini adalah jangan terlalu banyak berharap kepada seseorang yang belum tentu menjadi milikmu. Karena jika seseorang yang kita harapkan itu tidak dapat kita miliki maka yang kita dapatkan hanyalah kekecewaan.
X-ray diffuse scattering and polar nanoregion of a relaxor ferroelectric under electric field
Authors: Kondo Yuhei , Aoyagi Shinobu 
Published: June 2023

Abstract
We have measured X-ray diffuse scattering (XDS) of a relaxor ferroelectric 0.7Pb(Mg1/3Nb2/3)O3–0.3PbTiO3 single crystal under an electric field along [111] to investigate the electric field response of polar nanoregions (PNRs). Our ellipsoidal PNR model with a polarization along [110] and principal axes along [

1
¯

10

], [

111

], and [

11

2
¯

] well reproduced observed three-dimensional XDS intensities around each Bragg reflection under the electric field at 300 K. The dimension of the ellipsoidal PNR is estimated to be 0.6 × 1.8 × 1.2 nm3 along the principal axes. The electric field dependence of XDS strongly couples with the piezoelectric lattice strain and ferroelectric polarization switching. Irreversible changes in XDS intensities observed under the electric field are explained by an antiferroelectric dipolar stabilization of reoriented PNRs.
Verification of Error Correction Codes for CPU Memories
Authors: Ramesh Keerthana , Baliga Shwetha 
Published: June 2023

<p> This paper presents a strategy for the verification of error correction capability of SRAM memories in the CPU. The Error correction code used is a (72, 64) SEC-DED code that is capable of detecting 2 bit errors and correcting 1 bit errors in the memory. The strategy uses multiplexers to inject controlled bit flips into the memory only during verification. The RTL code for the ECC encoder and Decoder modules in written and the functional verification of ECC is performed using the error injection infrastructure that is built. Coverpoints are coded for various scenarios of error injection. These include controls for error injection in data bits or ECC bits, read path and write paths of the memory. Infrastructure is developed for single bit, multi- bit or a combination of both to be injected in a controlled fashion into the memory. This infrastructure is highly scalable to large memories as well. The infrastructure is completely synthesizable and hence suitable even for emulation. </p>
TOKSISITAS AKUT DAN LETHAL DOSE (LD50) EKSTRAK BUAH WALAY (Meistera chinensis) ASAL SULAWESI TENGGARA TERHADAP MENCIT (Mus musculus)
Authors: Musdalipah Musdalipah , Agung Wibawa Mahatya Yodha , Karmilah Karmilah , Selfyana Austin Tee , Reymon Reymon , Nur Saadah Daud , Muh. Azdar Setiawan , Esti Badia , Agustini Agustini 
Published: June 2023

Buah walay (Meistera chinensis) mengandung senyawa fenolat, flavonoid, steroid, terpenoid, alkaloid, dan saponin. Beberapa metabolit sekunder, termasuk triterpenoid dan flavonoid, memiliki potensi sebagai antioksidan, antibakteri dan toksisitas. Berdasarkan penelitian sebelumnya dengan menggunakan metode Brine Shrimp Lethality Test ekstrak buah Meistera chinensis memberikan efek sangat toksik dengan IC50 dari 5,02 ± 1,11 mg/mL. Penelitian ini bertujuan untuk mengetahui efek toksik yang ditimbulkan dari ekstrak buah walay ditinjau dari penentuan nilai LD50. Jenis penelitian ini adalah penelitian eksperimental. Penentuan kategori toksisitas berdasarkan Generally Recognized As Safe/GRAS dan perhitungan LD50 menggunakan Reed-Muench Penelitian menggunakan ekor mencit yang dibagi ke dalam 5 kelompok. Kelompok kontrol diberi Na-CMC 0,5 % dan kelompok perlakuan diberi ekstrak buah dengan dosis 50 mg/KgBB; 500 mg/KgBB; 5000 mg/KgBB dan 15.000 mg/KgB Rute pemberian yang digunakan adalah secara oral. Parameter yang diamati dalam penelitian ini adalah gejala toksik yang timbul dan nilai LD50 yang diperoleh berdasarkan perhitungan jumlah hewan uji yang mati. Hasil penelitian menunjukkan bahwa ekstrak buah walay memberikan gejala toksik berupa penurunan aktivitas gerak, laju nafas cepat serta tremor dan nilai LD50 adalah 865,765 mg/KgBB (Toksisitas ringan). Berdasarkan hasil penelitian dapat disimpulkan bahwa ekstrak buah walay (Meistera chinensis) memiliki efek toksik ringan.