bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative study on behaviour of conventional and pre- engineered buildings provided with different types of bracings
Authors: Bharmal Pravin. P. , Kumbhar Popat. D. , Gumaste Krishnakedar. S. 
Published: June 2023

Abstract
Steel is mostly preferred material by designers for industrial structures because of its advantageous properties namely tensile strength, ductility and durability. The industrial steel structures are commonly used for manufacturing and storage works requiring large uninterrupted dimensions. This requirement of structure is fulfilled by using pre-engineered buildings (PEB). PEB is one of the widely used concepts as it optimises the steel consumption in comparison with conventional steel building (CSB) and thus contributes in the reduction of cost and project duration without affecting the lateral stability during earthquakes. The lateral stability of structure is ensured by providing suitable bracing system. In this paper, comparative behaviour of conventional and pre-engineered buildings is studied by providing different type of bracings (viz. X, V, K and diagonal) using Staad pro. Results indicate that PEB with diagonal bracing reduces displacement and natural time period by 17.39% and 28.02% respectively when compared with CSB. The study concludes that, provision of diagonal bracing contributes in improving the performance of PEB.
Metastatic invasive lobular carcinoma of breast with gastric carcinoma as the first manifestation: A case report and review of the literature
Authors: CHEN ZhaoXu , WANG Xiao , ZHAO Peng , ZHAO Jing , FU GuangMing , WANG Chengqin 
Published: June 2023

Abstract
Invasive lobular carcinoma(ILC)is the second frequently diagnosed breast cancer with a low incidence of gastric metastasis. And metastatic ILC of breast with gastric tumor as the first symptom is more rare. Therefore, immunohistochemistry is the key to correct diagnosis. We reported a 45-year-old female patient who developed nonspecific systemic symptoms firstly. Imaging examination showed diffuse thickened gastric wall, and gastroscopic biopsy revealed a poorly differentiated adenocarcinoma. Twelve months after the diagnosis, a mass was found in the patient's left breast and was diagnosed as ILC on biopsy. Combined with the patient's medical history and immunohistochemistry results, the final diagnosis of metastatic ILC was made on gastroscopic biopsy. The clinicopathological characteristics of breast ILC with gastric metastases were reviewed in the light of the literature, and differentiated from primary poorly differentiated adenocarcinoma of the stomach to improve the clinicians' understanding. It could be a real challenge to differentiated patients with gastric metastasis of breast cancer from primary poorly differentiated adenocarcinoma of the stomach. Therefore, to improve the awareness of the clinicians, and to guide the choice of clinical treatment options, we should have an intimate knowledge of the clinicopathological characteristics of gastric metastases in breast ILC combining with the literatures.
Exposure to PM 2.5 and its constituents is associated with metabolic dysfunction-associated fatty liver disease: A cohort study in Northwest of China
Authors: Zhao Yamin , Peng Yindi , Wang Minzhen , Zhao Yanan , He Yingqian , Zhang Lulu , Liu Jing , Zheng Shan 
Published: June 2023

Abstract
Background
Accumulating animal studies have demonstrated associations between ambient air pollution (AP) and metabolic dysfunction-associated fatty liver disease (MAFLD), but relevant epidemiological evidence is limited. We evaluated the association of long-term exposure to AP with the risk of incident MAFLD in Northwest China.
Methods
The average AP concentration between baseline and follow-up was used to assess individual exposure levels. Cox proportional hazard models and restricted cubic spline functions (RCS) were used to estimate the association of PM2.5 and its constituents with the risk of MAFLD and the dose-response relationship. Quantile g-computation was used to assess the joint effects of mixed exposure to air pollutants on MAFLD and the weights of the various pollutants.
Results
We observed 1516 cases of new-onset MAFLD, with an incidence of 10.89%. Increased exposure to pollutants was significantly associated with increased odds of MAFLD, with hazard ratios (HRs) of 2.93 (95% CI: 1.22, 7.00), 2.86 (1.44, 5.66), 7.55 (3.39, 16.84), 4.83 (1.89, 12.38), 3.35 (1.35, 8.34), 1.89 (1.02, 1.62) for each interquartile range increase in PM2.5, SO42−, NO3−, NH4+, OM, and BC, respectively. Stratified analyses suggested that females, frequent exercisers and never-drinkers were more susceptible to MAFLD associated with ambient PM2.5 and its constituents. Mixed exposure to SO42−, NO3−, NH4+, OM and BC was associated with an increased risk of MAFLD, and the weight of BC had the strongest effect on MAFLD.
Conclusions
Exposure to ambient PM2.5 and its constituents increased the risk of MAFLD.
Prominent elevation of extracellular matrix molecules in intracerebral hemorrhage
Authors: Li Hongmin , Ghorbani Samira , Zhang Ruiyi , Ebacher Vincent , Stephenson Erin L. , Yong V. Wee , Xue Mengzhou 
Published: June 2023

Abstract
Background In many neurological conditions, the deposition of extracellular matrix (ECM) molecules is a prominent obstacle for regenerative processes and an enhancer of neuroinflammation. Whether ECM molecules alter in composition after intracerebral hemorrhage (ICH), and which ECM members may inhibit repair in hemorrhagic stroke, remain unknown.
Methods The collagenase-induced ICH mouse model and an autopsied human ICH specimen were investigated for expression of ECM members by immunofluorescence microscopy. Sections from a mouse model of multiple sclerosis were used as disease controls. Tissue culture was employed to examine the roles of ECM members on oligodendrocyte precursor cells (OPCs).
Results Amongst the lectican chondroitin sulphate proteoglycan members, neurocan but not aggrecan, versican-V1 and versican-V2 was prominently expressed in perihematomal tissue and lesion core compared to the contralateral area in murine ICH.
Fibrinogen, fibronectin and heparan sulphate proteoglycan were also elevated after murine ICH while thrombospondin was not. Confocal microscopy with Imaris 3D rendering co-localized neurocan, fibrinogen, fibronectin and HSPG molecules to Iba1+ microglia/macrophages or GFAP+ astrocytes. Marked differentiation from the multiple sclerosis model was observed, the latter with high versican-V1 and negligible neurocan. In culture, purified neurocan inhibited adhesion and process outgrowth of OPCs, which are early steps in myelination in vivo. The prominent expression of neurocan in murine ICH was corroborated in human ICH sections.
Conclusion ICH caused distinct alterations in ECM molecules, and prominently neurocan. In tissue culture, neurocan impeded the properties of oligodendrocyte lineage cells. Alterations to the ECM in ICH may adversely affect reparative outcomes after stroke.
Explainable Machine Learning Models for Medicare Fraud Detection
Authors: Hancock John Thomas III , Bauder Richard A , Wang Huanjing , Khoshgoftaar Taghi M 
Published: June 2023

Abstract
As a means of building explainable machine learning models for Big Data, we apply a novel ensemble supervised feature selection technique. The technique is applied to publicly available insurance claims data from the United States public health insurance program, Medicare. We approach Medicare insurance fraud detection as a supervised machine learning task of anomaly detection through the classification of highly imbalanced Big Data. Our objectives for feature selection are to increase efficiency in model training, and to develop more explainable machine learning models for fraud detection. Using two Big Data datasets derived from two different sources of insurance claims data, we demonstrate how our feature selection technique reduces the dimensionality of the datasets by approximately 87.5% without compromising performance. Moreover, the reduction in dimensionality results in machine learning models that are easier to explain, and less prone to overfitting. Therefore, our primary contribution of the exposition of our novel feature selection technique leads to a further contribution to the application domain of automated Medicare insurance fraud detection. We utilize our feature selection technique to provide an explanation of our fraud detection models in terms of the definitions of the selected features. The ensemble supervised feature selection technique we present is flexible in that any collection of machine learning algorithms that maintain a list of feature importance values may be used. Therefore, researchers may easily employ variations of the technique we present.
Evaluation of biochar as a soil amendment on the accumulation of cadmium on lettuce (Lactuca sativa)
Authors: Moazemi Behgol , Faramarzi Ali , Paknejad Farzad , Ajali Jalil , Abdi Mehrdad 
Published: June 2023

Abstract
Heavy metals decrease the plant health and production. It is important to provide a solution to reduce the absorption of heavy metals by plants. Application of biochar is useful for contamination rectification of heavy metals in soil. This 2-year (2018–2019) study was in order to investigation of biochar on the reduction of cadmium absorption in polluted soils on lettuce. The experiment was conducted as a factorial experiment was carried out in the form of a completely randomized design with 3 replications. The treatments were: biochar at two levels (0 and 5 v/v), cadmium at four levels (0, 10, 20, 30 ppm). The highest dry matter weight 11.25 g, was seen in biochar and control of cadmium and the lowest dry matter weight 6.39 g, was related to control of biochar and cadmium 30 ppm. The highest root dry weight 1.44 g, was observed in biochar and control of cadmium and the lowest root dry weight 0.54 g, was related to control of biochar and cadmium30 ppm. The plants yield was reduced in cadmium treatments. Biochar increased lettuce yield compared to control and due to the high absorption of heavy metals by biochar, it can be said it was a suitable choice as a soil amendments and reduced absorption of cadmium by plants.
The von Neumann inequality for 3x3 matricesin the unit Euclidean ball
Authors: Piekarz Dariusz 
Published: June 2023

Abstract
The counterpart of the von Neumann inequality for d-tuples of n×n commutative,row contractive matrices was proven by Hartz, Richter, and Sharit. In this paper,it is demonstrated that the minimal constant appearing in their theorem remainsindependent of the size of the d-tuple, provided that the integer d >=2 and n=3.Additionally, a numerical estimate of the constant is obtained.
Comparative chloroplast genome analysis of four Hippophae rhamnoides subspecies and its phylogenetic analysis
Authors: Wang Ruoqiong , Wang Xiangjie , Liu Zhihong , Han Youzhi , Xie Qing 
Published: June 2023

Abstract
Sea buckthorn(Hippophae rhamnoides), a hardy deciduous shrub of the family Elaeagnaceae, grows wild at high altitudes in Asia and Europe and is known for its great nutritional, medicinal and ecological value. In this study, the chloroplast genomesof four H. rhamnoidessubspecies, H. rhamnoides subsp. mongolica ‘wulanshalin’, H. rhamnoides subsp. caucasia, H. rhamnoides subsp. sinensis ‘wucixiong’, and H. rhamnoides subsp. yunnanensis, were characterized. The results showed that the genome length of these four subspecies ranged from 157,436 bp to 157,822 bp, with a typical quadripartite structure. Comparing the genome structure of these four subspecies, it was found that the chloroplast genomes were relatively conserved, retaining the same gene order. The annotation contained a total of 132 genes in each chloroplast genomes genome, with 86 protein-coding genes, 38 tRNA genes, and 8 rRNA genes. This study identified 14 highly differentiated regions and 423 simple sequence repeats loci, which can be used as potential molecular markers for H. rhamnoides. Meanwhile, Phylogenetic analysis showed that all Hippophae taxa were clustered in the same group and formed a sister clade with Elaeagnus taxa supported by Bayesian posterior probabilities. Among Hippophae taxa, H. gyantsensis, H. neurcar and H. salicifolia were grouped together, but H. tibetana was clustered with H. rhamnoide and the other six H. rhamnoide subspecies. The findings of this research will be useful for further studies on resource protection and the taxonomic classification of sea buckthorn.
Design of a Compound Reconfigurable Terahertz Antenna based on Graphene
Authors: Jin Zhao , Rong Yu , Yu JingDong , Wu Fei 
Published: June 2023

Abstract
In this paper, a terahertz dipole antenna with compound reconfigurability is designed, which possesses the capability of controlling frequency, radiation pattern, and polarization state. A capacitive load loop (CLL) made of graphene-metal composite material is applied around a pair of mutually orthogonal graphene-based dipole antennas. By controlling the bias voltage, the surface conductivity of graphene is adjusted, enabling compound reconfigurability. The graphene strips on the CLL provide a high degree of freedom for the radiation characteristics of the antenna. By adjusting the combination of chemical potentials of graphene, the operating frequency of the antenna can be reconfigured within the range of 1.40 THz to 1.84 THz. Moreover, it is possible to control the antenna to achieve directional radiation with four beams (0°, 90°, 180°, 270°) in the XOY plane at 1.75 THz, and ranging from 1.68 THz to 1.81 THz, it can be reconfigured to achieve controllable RHCL or LHCL.
Central projections from Johnston´s Organ in the locust: axogenesis and brain neuroarchitecture
Authors: Boyan George , Williams Leslie , Ehrhardt Erica 
Published: June 2023

Abstract
Johnston´s Organ (JO) acts as an antennal auditory organ across a spectrum of insect species and its axons universally project to the brain. In the locust, this pathway is present at mid-embryogenesis but the process of fasciculation involved in constructing it has not been investigated. Terminal projections into the fine neuropilar organisation of the brain also remain unresolved, information essential for providing insights into the neural circuitry mediating JO-mediated behavior and its evolutionary aspects. In our study here, we employ both neuron-specific and axon-specific labels to show that the pathway to the brain of the locust is built in a stepwise manner during early embryogenesis as processes from JO cell clusters fasciculate first with one another, and then with the two tracts constituting the pioneer axon scaffold of the antenna. A comparison of fasciculation patterns confirms that projections from cell clusters of the JO stereotypically associate with only one axon tract according to their location in the pedicel, consistent with a topographic plan. At the molecular level, all neuronal elements of the JO pathway to the brain express the lipocalin Lazarillo, a cell surface epitope we have shown regulates axogenesis in the primary axon scaffold and may also do so during fasciculation of JO projections to the brain. Central projections from JO first contact the primary axon scaffold of the mid-embryonic brain in the mechanosensory region of the antennal lobe but terminate in the protocerebrum. Examination of the neuroarchitecture of the adult brain reveals these terminals lie among the processes of premotor interneurons known to regulate flight behavior.
European and American Grapevines were Successfully Recovered from GFkV and GLRaV-1,2,3 Viruses by a Modified Thermotherapy and Shoot Tip Culture
Authors: SAĞLAM Hayri , SAĞLAM Özlem ÇALKAN , GÜLER Emrah , AKBAŞ Birol , GÜNER Üftade 
Published: June 2023

Abstract
The purpose of this study was to look into the use of thermotherapy and shoot tip culture to disinfect grapevines from Grapevine fanleaf nepovirus (GFLV), Grapevine fleck virus (GFkV), and Grapevine leafroll closterovirus (GLRaV) -1,-2,-3, all of which are required for certified sapling production. The GFkV, GLRaV-1,2,3-infected grapevine scions were taken from the initial testing and put into 10-liter plastic containers. They were rooted, and saplings were grown from them. The grapevines were then treated to a modified thermotherapy treatment for 40 days, which included 8 hours of darkness at 60–70% relative humidity and 32°C temperature and 16 hours of light (4000–5000 lux) at 60–70% relative humidity and 40°C temperature. The experimental materials were treated to shoot tip culture procedures after thermotherapy. At the end of the acclimation, all materials were tested again. At the conclusion of the testing procedures, the entire factory was virus-free. The survival rates of the grapevines differed, with 41B rootstock having a 100% survival rate and the rest having at least one survived plant out of six. When paired with rapid multiplication through in-vitro propagation, the proposed thermotherapy approach used in this study has a high potential for virus-free grapevine sapling propagation.
Disabled-2: a protein up-regulated by high molecular weight hyaluronan has both tumor suppressor and tumor promoting roles in ovarian cancer
Authors: Price Zoe K , Lokman Noor A , Sugiyama Mai , Koya Yoshihiro , Yoshihara Masato , Oehler Martin K , Kajiyama Hiroaki , Ricciardelli Carmela 
Published: June 2023

Abstract
Objective: Although the pro-tumorigenic functions of hyaluronan (HA) are well documented in ovarian cancer, there is limited information on the effects of different molecular weight HA. The aim of this study was to analyse the effects of different molecular weight HA on ovarian cancer cells overexpressing Notch3 intracellular domain (NICD3, stem cell associated protein).
Methods: Mass spectrometry analysis of spheroids from ES-2 cells overexpressing NICD3 (ES-2-Rv-NICD3) with wild type ES-2 (ES-2:ES-2-Rv-NICD3, 1:3) treated with 27kDa, 183kDa or 1000kDa HA identified a novel protein regulated by high molecular weight HA (HMW-HA), disabled-2 (DAB2). Correlations between DAB2 and patient prognosis and pro-tumorigenic signatures were assessed in online databases. DAB2 was assessed by immunohistochemistry in a tissue microarray cohort of high grade serous ovarian carcinoma (HGSOC) and matching tissues following relapse. Gain-of-function lentiviral methods were employed in A2780 and OVCAR3 ovarian cancer cells to determine the effect of DAB2 on cell survival, spheroid formation, gene expression, cell motility and invasion in vitro and in vivousing the chick chorioallantoic membrane (CAM) assay.
Results: HMW-HA (1000kDa) enhanced spheroid formation of ES-2:ES-2-Rv-NICD3 cells. Mass spectrometry identified DAB2 was upregulated 5.2 fold in HMW-HA treated ES-2:ES-2-Rv-NICD3 spheroids. Online database analysis showed DAB2 was downregulated in ovarian cancer compared to normal ovarian tissue but increased in metastatic compared to primary ovarian tumors. High DAB2 expression was associated with poor patient outcome and positively correlated with EMT markers. Stromal DAB2 immunostaining was significantly increased in matched tissues at relapse compared to diagnosis and associated with reduced survival. Furthermore, DAB2 protein co-localised with macrophage marker (CD68) in HGSOC tissues. In OVCAR3 but not A2780 cells, DAB2 overexpression enhanced carboplatin resistance and reduced cell motility and invasion in vitro. DAB2 overexpression reduced OVCAR3 and A2780 cell survival and in vivoinvasion in the CAM assay.
Conclusions: Our findings highlight that DAB2 has both tumor suppressive and pro-tumorigenic functions in ovarian cancer
Infection epidemiology in relation to different therapy phases in patients with haematological malignancies receiving CAR T-cell therapy
Authors: Poutón Nicol García , Ortiz-Maldonado Valentín , Peyrony Oliver , Chumbita Mariana , Aiello Tommaso Francesco , Monzo Patricia , Lopera Carlos , Alcalde Pedro Puerta , Magnano Laura , Martinez-Cibrian Nuria , Pitart Cristina , Juan Manel , Delgado Julio , Larrea Carlos Fernández , Soriano Álex , Urbano-Ispizua Álvaro , Garcia-Vidal Carolina 
Published: June 2023

Abstract
Background: We described the real-life epidemiology and causes of infections on the different therapy phases in patients with haematological malignancies undergoing chimeric antigen receptor (CAR) T-cells directed towards CD19+ or BCMA+ cells.
Methods: All consecutive patients receiving CAR T-cell therapy at our institution were prospectively followed-up. We performed various comparative analyses of all patients and subgroups with and without infections.
Results: 91 adults mainly received CAR T-cell therapy for acute leukemia (53%) and lymphoma (33%). We documented a total of 77 infections in 47 (52%) patients, 37 (48%) during the initial neutropenic phase and 40 (52%) during the non-neutropenic phase. Infections during the neutropenic phase were mainly due to bacterial (29, 78%): catheter infections (11 [38%] cases), endogenous source (5 [17%]), and Clostridiodes difficile (5 [17%]). Viral and fungal infections accounted for 14% and 8% of infections. Those patients receiving corticosteroids after CAR T-cell therapy had a higher risk of endogenous infection (100% vs 16%; p=0.006). During the non-neutropenic phase, bacterial infections remained very frequent (24, 60%), mainly with catheter source (8, 33%). Respiratory tract infections were common (17, 43%), frequently caused by viruses (14, 82%). There were no documented differences in patients with and without infections in this phase.
Conclusions: Infections after CAR T-cell therapy were frequent. During the neutropenic phase, it is essential to prevent nosocomial infections and balance the use of antibiotics to lower endogenous bacteraemia and Clostridial infection rates. It is also mandatory to improve preventive strategies for viral respiratory tract infections in later therapy phases.
Image encryption system based on a novel simultaneous permutation and diffusion framework utilizing modified Josephus traversing
Authors: Le Zhen , Chen Huang , Cai Shuting , Xiong Xiaoming , Huang Linqing 
Published: June 2023

Abstract
This paper proposes a novel image encryption system based on a new simultaneous permutation and diffusion framework utilizing modified Josephus traversing (SPDMJT). Firstly, SPDMJT utilizes the reverse scanning method to perform encryption process, guaranteeing the ergodicity of scrambling. Secondly, the diffusion is embedded into the Josephus traversing, preventing attackers from targeting the scrambling and diffusion phases separately. Thirdly, in order to enhance permutation effect, modified Josephus traversing employs a dynamic scrambling method where the scrambling scheme of the current pixel depends on the value of the previous diffused pixel. Moreover, SPDMJT adopts plaintext correlation both in scrambling and diffusion operation, which strikes a balance between ciphertext sensitivity and plaintext sensitivity, offering resistance against chosen-plaintext attacks (CPA), noise attacks and data loss. Simulation results show that the proposed algorithm has high encryption efficiency and can withstand various common attacks.