bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of encorafenib on survival of patients with BRAF V600E -mutant metastatic colorectal cancer in a real-world setting
Authors: Zurloh Marie , Goetz Moritz , Herold Thomas , Treckmann Jürgen , Markus Peter , Schumacher Brigitte , Albers David , Rink Andreas , Rosery Vivian , Zaun Gregor , Kostbade Karina , Pogorzelski Michael , Ting Saskia , Schmidt Hartmut , Stiens Ray , Wiesweg Marcel , Schuler Martin , Kasper Stefan , Virchow Isabel 
Published: July 2023

Abstract
Purpose: Patients with BRAFV600E mutant metastatic colorectal cancer (mCRC) have a dismal prognosis. The best strategies in these patients remain elusive. Against this background, we report the clinical course of patients with BRAFV600E mutant mCRC to retrieve the best treatment strategy.
Patients and Methods: Clinico-pathological data were extracted from the electronic health records. Kaplan-Meier method was used to estimate overall (OS) and progression-free survival (PFS). Objective response rate (ORR) was assessed according to RECIST 1.1.
Results: In total, 51 patients were enrolled. FOLFOXIRI was administered to 12 patients, 29 patients received FOLFOX or FOLFIRI as first-line treatment. Median OS was 17.6 months. Median PFS with FOLFOXIRI (13.0 months) was significantly prolonged (HR 0.325) as compared to FOLFOX/FOLFIRI (4.3 months). However, this failed to translate into an OS benefit (p=0.433). Interestingly, addition of a monoclonal antibody to chemotherapy associated with superior OS (HR 0.523). A total of 64.7% patients received further-line therapy, which included a BRAF inhibitor in 17 patients. Targeted therapy associated with very favourable OS (25.1 months).
Conclusion: Patients with BRAFV600E-mutated mCRC benefit from the addition of an antibody to first-line chemotherapy. Further line treatment including a BRAF inhibitor has a dramatic impact on survival.
Development of super-specific epigenome editing by targeted allele-specific DNA methylation
Authors: Rajaram Nivethika , Kouroukli Alexandra G. , Bens Susanne , Bashtrykov Pavel , Jeltsch Albert 
Published: July 2023

Abstract
Background
Epigenome editing refers to the targeted reprogramming of genomic loci using an EpiEditor which may consist of dCas9, DNMT3A/3L and sgRNA. Methylation of the locus can lead to a modulation of gene expression. Allele-specific DNA methylation (ASM) refers to the targeted methylation delivery only to one allele of a locus. In the context of diseases caused by a dominant mutation, the selective DNA methylation of the mutant allele could be used to repress its expression but retain the functionality of the normal gene.
Results
To set up allele-specific targeted DNA methylation, target regions were selected from hypomethylated CGIs bearing a SNP in their promoters in the HEK293 cell line. We aimed at delivering maximum DNA methylation with highest allelic specificity in the targeted regions. Placing SNPs in the PAM or seed regions of the sgRNA, we designed 24 different sgRNAs targeting single alleles. We achieved efficient ASM in multiple cases, such as ISG15, MSH6, GPD1L, MRPL52, PDE8A, NARF, DAP3, and GSPT1, which in best cases led to 5-10-fold stronger average DNA methylation at the on-target allele. This corresponds to average differences of the DNA methylation gain in on- and off-target alleles of > 50%. Maximum DNA methylation was observed on day 3 after transfection followed by a gradual decline. In selected cases ASM, was stable up to 11 day in HEK293 cells and it led to an up to 3.6 change in allelic expression ratios.
Conclusions
We successfully delivered ASM in multiple targets with high specificity, efficiency and stability. This form of super-specific epigenome editing could find applications in the treatment of diseases caused by dominant mutations, because it allows silencing of the mutant allele without repression of the expression of the normal allele thereby minimizing side-effects of the treatment.
High-temperature Corrosion of Ni-based Alloys in CO2-rich Gases
Authors: Oleksak Richard P. , Tylczak Joseph H. , Teeter Lucas , Carney Casey S. , Doğan Ömer N. 
Published: July 2023

Abstract
Future technologies require structural materials resistant to environmental degradation in high temperature CO2-rich environments. Herein we exposed several commercially available Ni-based alloys (230, 263, 282, 617, 625, 740H) to atmospheric pressures gases intended to simulate the compositions expected in future direct-fired supercritical CO2 power cycles. The alloys were exposed to 95% CO2 + 4% H2O + 1% O2 and the same gas containing 0.1% SO2 at temperatures of 600, 650, 700, 750, and 800°C for 2500 h. With minor exceptions, chromia scales formed on all alloys at all temperatures in the SO2-free gas, yielding parabolic growth rates that followed a clear Arrhenius temperature-dependence. Behavior in the SO2-containing gas was more complex. Generally, the alloys performed well at temperatures of 650, 750, and 800°C. While some alloys further performed relatively well across the whole temperature range, several of the alloys experienced chromia failure and higher oxidation rates at temperatures of 600 and 700°C. Deviation from protective behavior was associated with internal sulfide formation and, additionally for the case of 600°C, external sulfate formation. The thermodynamic and kinetic factors influencing the accelerated corrosion in the presence of sulfur are discussed. The results suggest that caution is required when assessing compatibility of Ni-based alloys for CO2-based systems when sulfur-based impurities are expected.
A Fault tolerant Multimedia Cloud Framework to guarantee Quality of Experience (QoE) in Live Streaming
Authors: Evangeline Preetha , Chandrakasan Bharanidharan , M Vetri Selvan , Palanisamy Anandhakumar 
Published: July 2023

Abstract

The massive scale of Cloud computing has enabled the popularity of the internet and growth of multimedia streaming. Live streaming applications have greatly benefitted on deploying it in the cloud environment due to its abundant availability of resources and features that handle scalability with agility. Managing Device heterogeneity is critical and affects user experience drastically. Response time and bandwidth are other issues to be focused on. The streaming services involve both desktop users and mobile users. High-definition video applications are often challenging for mobile devices due to their limited processing capability and bandwidth-constrained network connection. Cloud computing environments are elastic in nature which balances the load according to the fluctuations in the network. It is also easy to re-commission the required services in case of failures. But downgrade of services is possible. The reasons for the downgrade of services are many however hardware failure is one of the chief causes and queue overflow during re-commissioning is another. Whatever the cause, the effect of downgrade is drastic on the customer. To meet up with the problem of resource allocation, bandwidth allocation and fault tolerance issues and at the same time to guarantee the desired level of Quality of Experience (QoE) to the end-users, an entire framework is proposed with novel algorithms for all the addressed issues. The resource allocation, performed at the cloud end needs to be dynamic. Our framework incorporates the proposed Guess Fit algorithm to provision virtual machines dynamically based on priority scores calculated using probabilities as a result of the combined Naïve Bayes algorithm with association rule mining. The scores also take into account the hit ratios and the penalty values. It is found to perform better than the existing Fit algorithms. On the client end, an efficient cluster bandwidth allocation algorithm (CBA algorithm) is proposed to share bandwidth resources among the fixed device and the mobile devices in a cluster. The framework also incorporates a switching table-based fault tolerance module. The switching table is entirely built based on AND-OR logic and help in desktop migration for uninterrupted streaming.
A Secure Biometric Key Generation Based on Coordinate Attention Mechanism And Reliable Feature Selection
Authors: zhou yang , WANG MingWen 
Published: July 2023

Abstract
With the development of the information era, the study of biometric keys has attracted increasing attention. However, the performance and safety of the proposed methods seem challenging to meet the needs of real applications. To solve this problem, this paper presents a finger vein biometric key system. The proposed system proposes an improved network in the feature extraction stage, which combines the coordinate attention mechanism and SkipNet to obtain richer feature information. An improved, reliable feature selection method is introduced to acquire more discriminative finger vein features. A Lagrange interpolation method then binds the user's finger vein features and keys. Finally, experiments are carried out on the public USM, Poly, and Net64 databases. The results indicate that we acquire a 1024-bit key with 0.049% FAR and 0% FRR in Net64 and 0% FAR and FRR in USM and Poly. Additionally, the system's security is analyzed from key randomness, system information leak attack, brute force attack, cross-matching attack, and spoofing attack. Experimental and theoretical analyses show that the proposed system has good accuracy and security.
Human umbilical cord mesenchymal stem cells repair endothelial injury and dysfunction by regulating NLRP3 to inhibit endothelial cell pyroptosis in Kawasaki disease
Authors: Xu ting , Chen Tao , Fang Hao , Shen Xiwei , Shen Xianjuan , Tang Zhiyuan , Zhao Jianmei 
Published: July 2023

Abstract
Vascular endothelial inflammation and endothelial dysfunction are the main causes of endothelial injury in Kawasaki disease (KD). Human umbilical cord-derived mesenchymal stem cells (Huc-MSCs) have multiple functions in immune regulation. This study examined whether Huc-MSCs inhibited endothelial inflammation and improved endothelial function in KD through constructing cell and in vivo animal KD vasculitis models. The pyroptosis factor NLRP3 was involved in the inflammatory process in the acute phase of KD. After tail vein injection of Huc-MSCs, inflammatory cell infiltration and the expression of pyroptosis-related proteins in the LCWE-induced KD mouse vasculitis model were significantly reduced. In vitro, NLRP3-dependent pyroptosis successfully induced HUVECs damage. Huc-MSCs effectively increased the abilities of impaired HUVECs to proliferate, migrate, invade, and form vessel-like tubes, while inhibiting their apoptosis, suggesting that Huc-MSCs can reduce inflammation and improve vascular endothelial function by inhibiting the NLRP3-dependent pyroptosis pathway in KD, providing a possibility and novel target for KD endothelial injury and dysfunction.
The Role of Unemployment in the ESG Model at World Level
Authors: Leogrande Angelo , Leogrande Domenico , Costantiello Alberto 
Published: July 2023

Abstract
In this article, we investigate the role of Unemployment-U in the context of Environmental, Social and Governance-ESG model at World Level. We use data from 193 countries in the period 2011-2021. We apply Panel Data with Random Effects, Panel Data with Fixed Effects, Pooled Ordinary Least Squares-OLS, and Weighted Least Squares-WLS. We found that among other the level of U is positively associated, among others, to “GHG Net Emissions” and “Government Effectiveness”, and negatively associated among others, to “Maximum 5 Day Rainfall” and “Political Stability and Absence of Violence/Terrorism”. Furthermore, we confront eight different machine-learning algorithms to predict the future value of U. We found that the best predictive algorithm in terms of maximization of R-squared and minimization of MAE, MSE, and RMSE is the Linear Regression. The value of U is expected to growth of 1.51% on average for the analysed countries.
JEL Codes: D7, D70, D72, D73, D78.
Green synthesis of pyrazolines as an anti-inflammatory, antimicrobial and antioxidant agents
Authors: Pawar Kiran Prakash , Bhosale Sachin , Dhake Avinash , Shinde Nirmala 
Published: July 2023

Abstract
Green methods such as microwave technique and grinding technique has been found superior over the conventional method in view of reaction time and energy requirement. Comp research (2a-i), (3a-i) have been characterized by 1H NMR, 13C NMR, IR and mass spectral analyses. They were screened for their in vitro anti-inflammatory, antimicrobial and in vitro antioxidant activities. Antimicrobial activity was performed by Agar plate method and comp. 2d & 2e a active against gram negative bacteria E. coli and S. aureus, the comp. 3c and 3g show antioxidant activity as (IC50 = 48.13 and 46.03µg/ml), Comp’ 3c shows respectively anti-inflammatory activity at (EC50 = 11.00 ± 1.26 µg/mL). Comp. ,3c ,3d and 3e showed good anti-inflammatory activity at concentration (EC50 = 11.70 ± 0.98 µg/mL) & 11.70 ± 0.98 µg/mL respectively.
Covid-Induced Intimate Partner Violence: Scoping Review from Africa between 2020 – 2022
Authors: Wilson ANSAH Edward , ASAMOAH Anthoniette , BIMPEH Bernice , ANANI-ADZOE Laurenda F. , BOTHA Nkosi Nkosi 
Published: July 2023

Abstract
Intimate Partner Violence (IPV) gained global notoriety as a preventable public health menace affecting 30% of females worldwide. The IPV which is implicated as a significant cause of premature mortality and morbidity worldwide has increased during the pandemic. Therefore, the purpose of this review is to synthesis evidence of the impact of the SARS-Cov-2 pandemic on incidence of IPV in Africa, occurring from 1st January, 2020 to 31st December, 2022. Using Tricco et al. procedure, thorough literature search was done in PubMed, Cochrane Library, ScienceDirect, Dimensions, Taylor and Francis, Chicago Journals, Emerald Insight, JSTOR, Google Scholar, and MedRxiv. Consistent with the inclusion and exclusion protocols, 10 peer reviewed articles were eligible and used for this review. We report that : i) the SARS-COV-2 pandemic escalated the vulnerabilities of people to economic hardship, resulting in increased incidence of IPV during 2020–2022 in Africa, ii) psychological/emotional abuse was the most prevalent form of IPV victims suffered, iii) mental health conditions were the most reported effects of IPV on victims. The prevalence of IPV could undermine the achievement of the SDGs 5.2 by Africa, limiting the content’s quest to achieve full eradication of all types of violence against females. We recommend financial supports for females through social schemes like the Livelihood Employment against Poverty, as in Ghana, create sustainable livelihood for females and intensify public sensitisation on IPV and education on help-seeking avenues. It is important that a study is carried out to assess the structures available for dealing with IPV in Africa.
Activity of a Public Company in the Stock Market: Sensitivity Analysis of Its Key Indicators in the Context of a Neutral Approach to the Implementation Of Dividend Policy
Authors: Krylov Sergey 
Published: July 2023

AbstractResearch backgroundIn the conditions of a modern developed market economy, a rather important characteristic of the activities of a public company is its activity in the stock market (market activity), which involves the development of a dividend policy, which, on the one hand, should contribute to the achievement of the main goal of financial management - maximizing the material well-being of shareholders, and, on the other hand, take into account the interests of all other stakeholders interested in the activities of a public company (including potential investors) to ensure its sustainable development in the long term. Fulfillment of this requirement is possible only within the framework of a neutral approach to the implementation of the dividend policy of a public company.PurposeThe article is devoted to the consideration of the conceptual foundations for analyzing the sensitivity of key indicators of the activity of a public company in the stock market (market activity) to the main determining factors in the context of a neutral approach to the implementation of its dividend policy.Design/methodology/approachThe methodological basis of the study was the concept of a neutral approach to the dividend policy of a public company and the concept of sensitivity analysis, developed earlier by the author of this article.FindingsIt is shown that the key indicators of the market activity of a public company include the dividend yield ratio, dividend coverage ratio, the expected price of an ordinary share, the dividend yield of an ordinary share and the quote ratio of an ordinary share (price and earnings ratio per ordinary share). An analysis of the sensitivity of these indicators to the main determining factors in the context of a neutral approach to the implementation of the dividend policy of a public company involves the construction of appropriate elasticity models that allow determining the change in key indicators of market activity depending on changes in the factors that determine them. The constructed elasticity models of the key indicators of market activity listed above can be used in predictive and analytical assessments of their changes, and also make it possible to identify the causes of these changes by calculating the impact on the specified elasticity of the determinants contained in their models, performed by the appropriate methods of factor analysis, under the conditions of a neutral approach to the implementation of the dividend policy of a public company.Originality/valueThe author comes to the conclusion that the elasticity models developed by him for key indicators of the activity of a public company in the stock market in terms of the main factors determining them are a fairly effective tool for managing the market activity of a public company in the context of a neutral approach to the implementation of its dividend policy.JEL codes:C15, G32, G34, G35
Myocardial Work Combined with a Cardiopulmonary Exercise Test is a Useful Prognostic Assessment of Patients with Non-obstructive Hypertrophic
Authors: Lin Yufen , Hou Shuhong , Lin Jianting , Zhang Tingting , Wu Bo , Qiu Sihua , Chen Jinhui , Chen Dongping , Huang Junlong 
Published: July 2023

Abstract
Background: The aim of this study was to evaluate the prognosis of patients with non-obstructive hypertrophic cardiomyopathy (HCM) using myocardial work combined with a cardiopulmonary exercise test (CPET). The association between myocardial work and CPET parameters and left ventricular wall thickness was investigated. To achieve the study aim, 55 patients with non-obstructive HCM and 55 healthy control participants were enrolled. Echocardiographic data were collected and compared, and a CPET was performed separately for patients with HCM and controls. Differences in CPET and myocardial work parameters and changes in myocardial work parameters from before to after the CPET were compared between the two groups.
Results: Global longitudinal strain, global work index, global constructive work (GCW), and global work efficiency parameters were significantly reduced and longitudinal strain peak time dispersion (PSD) was prolonged in patients with HCM compared to controls (P < 0.001). No difference in global wasted work was observed between the two groups (P > 0.05). Regarding CPET parameters, peak oxygen uptake, anaerobic threshold, oxygen pulse, and metabolic equivalents were significantly lower in the HCM group compared with the control group (P < 0.05). The slope of carbon dioxide ventilation equivalent was higher in patients with HCM, but the between-group difference was not significant (P > 0.05). After the CPET, there was a significant increase in PSD, but not GCW, in the HCM group, while there was a significant increase in GCW, but not PSD, in the control group. Maximal wall thickness showed a significant positive correlation with PSD (r =0.84, P <0.001), a significant negative correlation with GCW (r =-0.84, P <0.001), and a weak negative correlation with peak oxygen uptake (r =-0.45, P <0.001).
Conclusion: Myocardial work combined with a CPET can provide a valid assessment of the prognosis of patients with HCM. The effective myocardial work and CPET parameters are negatively correlated with left ventricular wall thickness.
Comparison of surgical outcomes in patients with closed nerve injuries in upper and lower extremities
Authors: Bazhanov Sergey P. , Shuvalov Stanislav D. , Tolkachev Valdimir S. , Korshunova Galina A. , Ostrovskij Vladimir V. 
Published: July 2023

Abstract
Patients with closed injuries of their brachial plexus and sciatic nerves make one of the most challenging cohort of patients as the recovery from the lost functions are rare and the number of disabilities is high. This is due to the damage by axonotmesis type when the anatomical integrity of the nerve trunk is preserved. For these patients the use of microsurgical neurolysis or electrical stimulation alone may turn ineffective, it’s also difficult to figure out the time for starting the procedures and proper stimulation modes. Thus, the investigation of the traumatic damage to peripheral nerves as well as various methods of surgical management of this cohort of patients is an urgent issue in neurosurgery, neurology, traumatology, orthopedics and rehabilitation.
This study as aimed to compare the outcomes of various surgical methods in patients with closed injuries of their brachial plexus and sciatic nerves.
Material and methods. The study involved 190 patients; 96 had closed injuries of their brachial plexus and 94 had closed injuries of their sciatic nerves. All patients were examined and treated in 2005-2021. These individuals were divided into three groups homogeneous by their gender, age and severity of neurological deficit: Group I (n=62) patients underwent microsurgical neurolysis, Group II (n=60) patients had microsurgical neurolysis followed by the single-level electrical stimulation, and Group III (n=68) patients had microsurgical neurolysis followed by the two-level electrical stimulation. The assessment of the clinical and functional status of the upper limb was carried out in dynamics using scale methods. The changes in clinical and functional status of the extremities were assessed with scale methods.
Results. We observed a better recovery of the limb functions in those patients who experienced the combination of microsurgical neurolysis and two-level electrical stimulation.
Conclusion. This technique improves surgical outcomes in patients with closed injuries of their brachial plexus and sciatic nerves due to faster pain relief and positive changes in clinical scores.
Composite exopolysaccharide-based hydrogels extracted from Nostoc commune V. as scavengers of soluble methylene blue
Authors: Herrera Nora Gabriela , Villacrés Nelson Adrián , Aymara Lizbeth , Román Viviana , Ramírez Mayra 
Published: July 2023

The industrial water contamination with synthetic dyes is currently a cause for concern. This paper introduces composite hydrogels as alternative scavengers of soluble dyes.
This research used kinetic models and adsorption isotherms to test composite exopolysaccharide hydrogels extracted from Nostoc commune V., pectin, and starch for their ability to remove methylene blue from water.
The exopolysaccharides demonstrated a rather low extraction yield and a crystallinity percentage of 38.21%. However, the crystallinity increased in the composite hydrogels (48.95%) with heterogeneous surface. The pseudo-second-order kinetic model served to explain the adsorption mechanism at pH 8 and pH 11, while the Elovich model explained the adsorption mechanism at pH 5. When in acid fluid, the hydrogels had a heterogeneous surface, whereas alkaline fluid resulted in a homogeneous surface. The Temkin adsorption model showed a good fit in the treatments.
At a basic pH value, composite exopolysaccharide-based hydrogels showed good results as scavengers of low-concentration methylene blue.