bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of antibody titer and side effects after fourth doses of COVID-19 mRNA vaccination in 38 healthy volunteers
Authors: Kozakai Rikei , Suzuki Susumu , Sato Yuri , Takahashi Mizue , Chida Nodoka , Takahashi Mei , Hoshi Kuniko , Takahashi Shinichiro 
Published: June 2023

Abstract

Objectives
Fourth dose of SARS-CoV-2 vaccination was started from the end of May, 2022 in Japan. However, data on the precise analysis of the side effects after fourth vaccination, remain scarce. Here, we examined the side effects and the levels of SARS-CoV-2 antibody titers in healthy volunteers who underwent BNT162b2 vaccination for the fourth time.

Methods
Thirty-eight volunteers were assessed for the side effects of the vaccination for the fourth dose, and samples were used for the measurement of SARS-CoV-2 IgG and IgM antibody with chemiluminescent assays.

Results
We found that the level of IgG at day 504 (average, 117.9 AU/mL [SD 76.9]), was significantly higher than at day 264 (average, 17.3 AU/mL [SD 13.1]), which are 8 months after the third and second vaccination, respectively. The level of IgG was potently increased after fourth vaccination (average, 711.8 AU/mL [SD 361.9]), whereas IgM remained baseline level. Commonly reported side effects in the participants after the fourth dose were similar to those until third dose, such as sore arm/pain (81.0 %), generalized weakness/fatigue (57.1 %) and fever (54.8 %). The number of side effects were significantly decreased with age, and participant with sore arm/pain had higher IgG titer (p=0.0007), whereas participant with lymphadenopathy had lower IgG (p=0.0371).

Conclusions
The level of IgG was significantly higher in 8 months after the third, compared to the second, vaccination, and it was potently increased after fourth vaccination. The number of side effects were inversely correlated with age. Sore arm/pain and lymphadenopathy may affect IgG titer.
Development and validation of a nomogram for predicting survival in patients with pancreatic ductal adenocarcinoma after radical pancreatoduodenectomy
Authors: Wang Yanwei , Cui Chenghao , Yu Qiang , Li Mingtai , Liang Yurong 
Published: June 2023

Abstract

Objectives
Hypercoagulation and malnutrition are the characteristic pathophysiological changes associated with pancreatic ductal adenocarcinoma (PDAC), which are intimately related to cancer progression and prognosis. We aimed to integrate related indicators to build a nomogram model to predict the overall survival (OS) of PDAC patients underwent radical pancreatoduodenectomy (PD).

Methods
Clinicopathological and survival data of 138 patients were retrospectively analyzed according to inclusion and exclusion criteria. A nomogram was built based on the multivariate Cox regression analysis. The receiver operating characteristic curve (ROC) and calibration curves were performed based on the bootstrap method to evaluate the predictive performance of the nomogram. Decision curve analysis (DCA) was performed to assess the clinical usefulness of the nomogram.

Results
High-grade tumor (Hazard ratio [HR]: 3.70; 95% confidence interval [CI]: 1.51–3.82; p<0.001), vessel carcinoma embolus (HR: 2.69; 95% CI: 1.30–5.31, p=0.007), N2 (HR: 2.90; 95% CI: 1.47–7.37; p=0.004), anemia (HR: 1.98; 95% CI: 1.01–2.70; p=0.047), PLR>244.8 (HR: 2.13; 95% CI: 1.05–3.45; p=0.033), FBG>3.50 g/L (HR: 2.10; 95% CI: 1.04–3.09, p=0.008), and DRR>1.1 (HR: 2.69; 95% CI: 1.56–4.27; p<0.001) served as independent risk factors for poor OS of patients with PDAC underwent radical PD and were implemented to construct a nomogram. The area under curve (AUCs) for the first, second, and third years were 0.713, 0.777, and 0.845, respectively. Besides, calibration curves fitted well to the ideal line. DCA shows that the nomogram has greater net benefit than the existing TNM staging system, suggesting that this model is a more practical clinical tool for predicting the prognosis of PDAC patients.

Conclusions
The nomogram we established based on the characteristic pathophysiological alterations of PDAC for predicting OS in patients who underwent radical pancreatoduodenectomy presented considerable predictive power. It may facilitate prognostic risk stratification and optimize therapeutic decision-making.
Hypoxia-inducible factor 1α (HIF-1α)-activated Gli1 induces invasion and EMT by H3K4 methylation in glioma cells
Authors: Lin Yihai , Wu Zhangyi 
Published: June 2023

Abstract

Objectives
Gliomas are highly aggressive neuroepithelial-layer malignancies. Hypoxia-inducible factor 1α (HIF-1α) was revealed to be upregulated in gliomas under hypoxia. Nevertheless, its role in glioma cells remains elusive. We attempted to clarify the molecular mechanism of HIF-1 underlying glioma.

Methods
Cellular models were established to mimic the characteristics of hypoxia. RT‒qPCR was used to detect HIF-1α and Gli1 levels in glioma cells with or without hypoxic treatment. Transwell assays were used to measure the invasive ability of U87 and U251 cells. Western blotting was used to evaluate epithelial-mesenchymal transition (EMT)-associated protein abundance and H3K4 methylation (H3K4me)-associated protein abundance in U87 and U251 cells. ChIP assessed the association of HIF-1α or H3K4me with the Gli1 promoter in glioma cells.

Results
HIF-1α and Gli1 were upregulated in glioma cells relative to normal human astrocytes (NHAs). HIF-1α and Gli1 were also upregulated in hypoxia-treated glioma cells relative to untreated glioma cells. Both HIF-1α and Gli1 silencing suppressed glioma invasion and EMT under hypoxia. HIF-1α upregulated Gli1 transcriptionally via MLL1-mediated H3K4me. H3K4me mutation silencing was further demonstrated to suppress glioma cell invasion and EMT under hypoxia.

Conclusions
Both HIF-1α and Gli1 are upregulated in glioma cells and function as oncogenes in glioma cells. HIF-1α transcriptionally activates Gli1 via MLL1-mediated H3K4 methylation in glioma cells, providing ideas for seeking new therapeutic directions for glioma.
SET domain containing protein 8 (SET8) promotes tumour progression and indicates poor prognosis in patients with laryngeal squamous cell carcinoma
Authors: Lan Li-Li , Liu Sheng-Hui , Fan Zhi-Tao , Wang Xue-Xia , Wang Jing-Tian , Wang Ke-Xin , Zhao Rui-Li 
Published: June 2023

Abstract

Objectives
SET Domain Containing Protein 8 (SET8), a member of the SET domain containing methyltransferase family involved in several biological processes and SET8 expression levels, reportedly affects the outcomes of patients with breast cancer, renal cancer, prostate carcinoma, and oesophageal squamous cell carcinoma. However, there have been no relevant studies on the biofunction and use of SET8 expression in the prediction of laryngeal squamous cell carcinoma (LSCC) outcomes.

Methods
In our study, SET8 expression levels were detected using immunohistochemical staining, western blotting, and quantitative real-time RT-PCR (qRT-PCR) with semi-quantitative analysis for laryngeal cancer outcomes. Additionally, we assessed the influence of SET8 on the behaviour of laryngeal cancer cells in vitro, using cell counting kit-8, clone formation, wound healing, and Transwell invasion assays. We subsequently performed qRT-PCR and western blotting for an in-depth study of SET8.

Results
Our study showed marked upregulation of SET8 in tumour tissues and laryngeal cancer cell lines. High SET8 expression predicts poor prognosis in patients with LSCC, and its expression can be used as an independent predictor of LSCC outcome. Subsequent functional analyses indicated that SET8 knockdown exerted an inhibitory effect on proliferation, migration, and invasiveness in vitro.

Conclusions
SET8 may be associated with epithelial-mesenchymal transition. Our results demonstrate that higher SET8 expression is an unfavourable prognostic predictor and exerts tumour-promoting effects in LSCC.
What motivates critical care nurses to stay in their job? A scoping review protocol
Authors: Teutsch Dagmar , Frick Eckhard , Kubitza Jenny 
Published: June 2023

Abstract

Objective

The aim of this scoping review (Registration https://doi.org/10.17605/OSF.IO/28NKU) is to understand the extrinsic and intrinsic factors that motivate critical care nurses to stay in their job.

Introduction

Previous reviews failed to consider both critical care nurses who stay in their job as well as other critical care nurses who have already left the job or switched from critical care to another medical discipline. Moreover, the literature mainly discusses extrinsic factors that lead to job attrition and turnover, but misses out to exemplify intrinsic factors and to put both in relation to one another.

Inclusion criteria

The inclusion criteria will be described by applying the PCC-framework (Population, Context, Concept). The population is limited to fully qualified critical care nurses who currently work or have been working in the field of critical and emergency care. The context is defined within critical care (intensive care units and emergency care in hospitals). Other contexts (e. g., common surgical wards, palliative care) are excluded. The concept is the personal motivation concerning professional engagement.

Methods

Eleven databases and grey literature from 2015–2023 will be searched. We will apply a two-stage screening process by at least two independent reviewers. First, titles and abstracts will be scanned. In a further step, relevant articles will receive a full-text review. Finally, the research team (approx. 5–6 persons) will discuss the extracted data independently.

Ethics and Dissemination

Ethical approval is not required for scoping reviews. Dissemination will include submission to peer-reviewed journals and presentations in conferences and workshops in the area of critical care.
Estimators of tissue absorption parameters power-law prefactor and power-law exponent from medical ultrasonic images
Authors: Brandner Dinah Maria , Zagar Bernhard G. 
Published: June 2023

Abstract
Ultrasound is a mechanical wave propagating in tissue which is influenced in its propagation behavior by the locally prevailing acousto-mechanical conditions. By suitable processing of the back-scattered signals received by the ultrasound transducer, tissue parameters such as local bulk modulus, mass density, speed of sound, isotropic scattering coefficient, and also the locally acting tissue absorption can be inferred. A discipline that has received increasing attention in the medical ultrasonic imaging discipline and its scientific publications in recent years is quantitative ultrasound (QUS) which tries to estimate with great accuracy these local acting tissue parameters. In this paper we analyze different algorithms for estimation of high spatial resolution tissue absorption parameters. On the one hand, there is a simple absorption estimator based on the evaluation of the quotient of the power density spectra calculated for different depth regions (spectral-log-difference estimator), which, however, assumes a linearly with frequency increasing absorption, this is contrasted with an estimator which also allows to estimate a polynomial increase of the absorption with frequency (method-of-moments estimator). Since a closed-form solution cannot be given for this, a maximum-likelihood estimator for which there is always an estimate that can be computed numerically efficiently is developed. The results, tissue attenuation, are presented as a color-coded overlay on conventional B-mode ultrasound images showing only morphology.
Über die Assoziation von Namen mit privaten Empfindungen – ein Kommentar zu Wittgensteins Privatsprachenargument (PU 256 – 265)
Authors: Lüdeking Matthias 
Published: June 2023

Abstract

On the Association of Names with Private Sensations – A Commentary on Wittgenstein’s Private Language Argument (PI 256 – 265). This commentary on PI 256 – 265, informed by Wittgenstein’s Nachlass and the recently published Skinner dictations, shows that Wittgenstein uses a particular method in these sections: He investigates what kind of meaning one might give to the parts of a philosophical sentence. Wittgenstein recommended this method already in TLP and BBB – it marks a continuity in his thought. The sentence under investigation is the following: “And now I simply associate names with sensations” (PI 2009: 256). PI 257 – 265 discuss three proposals of what it might mean to associate a name with a private sensation. PI 257 investigates the claim that the association is set up by means of inventing a name, PI 258 proposes that it consists in a private ostensive definition, and PI 262, 263 suggest that it works by (inwardly) resolving to call this like that. All of these ideas turn out to be unsatisfactory. The reason why PI 258’s private ostensive definition fails is that for a private sensation there is by definition no difference between “it is the same” and “he recognized it”. This is why one cannot talk of recognition here, and therefore the private ostensive definition is an empty ceremony. The result of PI 256 – 265 is not a proof of the impossibility of a private language, but these sections show that the meaning of “And now I simply associate names with sensations” cannot satisfactorily be explained by means of the three aforementioned proposals.
Die Baumstruktur des Tractatus: Genesis, Lesarten, Editionen
Authors: Stern David 
Published: June 2023

Abstract

Tree-Structured Readings of the

Tractatus

: I argue that the numbering system of the Tractatus lets us see how it was constructed, in two closely related senses of that term. First, it tells us a great deal about the genesis of the book, for the numbering system was used to assemble and rearrange a series of drafts, as recorded in MS 104. Second, it helps us understand the structure of the published book, as cryptically summarized in the opening footnote. I also discuss an unpublished letter from Anscombe to von Wright from 1948 which contains the very first sketch of a tree-structured reading, and what I believe is Stenius’s response to Anscombe’s proposal. The paper critically evaluates previous work on tree-structured readings and contends that we need to read the Tractatus in both the number order used in the published book and the tree order that Wittgenstein used to draft it. It also considers some of the main ways of turning this complex branching structure into a linear, printed text, and so serves as an introduction to the three tree-structured editions of the Tractatus that accompany the original English-language publication of this paper in NWR 11 (the German text, and the translations by Ogden & Ramsey and Pears & McGuinness).
Central hyperthyroidism combined with Graves' disease: case series and review of the literature
Authors: Mo Caiyan , Chen Han , Zhang Qi , Guo Ying , Zhong Liyong 
Published: June 2023

Background
Central hyperthyroidism is characterized by elevated free thyroid hormone and unsuppressed thyroid-stimulating hormone (TSH), and this laboratory feature includes TSH-secreting pituitary adenoma (TSHoma) and resistance to thyroid hormone β (RTHβ). Central hyperthyroidism combined with Graves’ disease (GD) has been rarely reported.

Case Report
We describe three patients with TSHoma combined with GD and one patient with GD combined with RTHβ and pituitary adenoma. These three patients with TSHoma combined with GD showed elevated thyroid hormone, while TSH level was normal or elevated, and TSH receptor antibodies were positive. After thyrotoxicosis was controlled, they all underwent transsphenoidal surgery. We also describe a patient with an initial presentation of GD who developed hypothyroidism after anti-hyperthyroidism treatment and TSH was inappropriately significantly increased. His head magnetic resonance imaging revealed a pituitary adenoma. Genetic testing confirmed a heterozygous mutation in the thyroid hormone receptor β gene c.1148G>A (p.R383H). After levothyroxine and desiccated thyroid tablet treatment, the TSH level decreased to normal.

Conclusion
These four cases highlight the need to consider the diagnosis of GD combined with central hyperthyroidism when faced with inconsistent thyroid function test results, illuminating the specific diagnostic and therapeutic challenges of coexisting primary and central hyperthyroidism. Finally, we propose clinical management for central hyperthyroidism combined with GD.
La triple identidad: Error de comprensión culturalmente condicionado, pluriculturalidad y territorialidad
Authors: Aranibar-Ramos Edgar Romario , Zanabria-Cabrera Luis Carlo , Díaz-Idme Fabrizio Manuel 
Published: June 2023

En el territorio peruano se tiene noción de la existencia de diferentes culturas, pero no en su totalidad. De esta forma, la búsqueda de conocimiento no se limita a patrones culturales propios de la normativa vigente de un Estado o teorías abstractas. Por ello, se desarolla la perspectiva desde tres realidades: sector urbano, rural y no contactado; con el objetivo de profundizar la necesidad de considerar la pluriculturalidad como punto de partida en los delitos interculturales, en aras de la heterogeneidad cultural y realismo social. Siendo así, la aplicación normativa de un sector dominante sobre los intereses de las minorías -sector rural y no contactado- presenta limitaciones conceptuales y prácticas en la realidad doméstica peruana. En esa línea, se propone una visión holística y coherente a supuestos prácticos de la mano de dos ciencias: antropología y el derecho; a efecto de hacer hincapié en la existencia de una sociedad culturalmente independiente como un ente autónomo trabajado de la mano del derecho consuetudinario y el aprendizaje, como sinónimo de cultura y necesidad ante la existencia de vacíos legales que pretenden imponer un modelo restrictivo de derechos, relegando el respeto al derecho a la dignidad, principio de territorialidad, autonomía, previsibilidad e identidad
Cuando Hollywood encontró a Harlem: caminos para la creación de un nuevo modelo de representación de la identidad afroamericana en el cine de los estudios (1970-1971) / When Hollywood Met Harlem. How the Industry Created a New Model of Representation of the Afro-American Identity in American Cinema
Authors: Fernández Meneses Jara 
Published: June 2023

Desde una perspectiva histórica, este artículo analiza las estrategias empleadas por el cine norteamericano a comienzos de la década de 1970 para elaborar un nuevo modelo de representación de la comunidad afroamericana. A través del análisis del contexto socio-político y económico de ese periodo, el texto examina los dos principales elementos que explican dicho fenómeno: la crisis que sufrió la industria cinematográfica a finales de la década de 1960 y el nacimiento de una nueva conciencia racial dentro del movimiento de los derechos civiles a comienzos de la década de 1970. Tres películas se utilizan para ilustrar cómo se construyó este nuevo modelo y cuáles son sus principales atributos: Algodón en Harlem (Cotton Comes to Harlem, Ossie Davies, 1970), Sweet Sweetback’s Baadasssss Song (Melvin Van Peebles, 1971) y Las noches rojas de Harlem (Shaft, Gordon Parks, 1971). A través de la comparación entre cómo la industria representó a los afroamericanos en décadas previas y cómo lo hizo en el periodo estudiado, el artículo pretende demostrar cómo y por qué Hollywood cambió su actitud hacia el retrato de la comunidad afroamericana.Palabras clave: Identidad afroamericana, directores afroamericanos, blaxploitation, Cotton Comes to Harlem, Sweet Sweetback’s Baadasssss Song, Shaft, Ossie Davies, Melvin Van Peebles, Gordon Parks.AbstractAssuming a historical approach, this text focuses on the strategies used by American cinema to elaborate a new model of representation of the Afro-American identity in the early seventies. Through the analysis of the socio-political and economic context of the period, this text examines the two main issues we should take into consideration to explain this fact: the crisis in the cinema industry in the late sixties and the rising of a new conscience within the afroamerican civil rights movement at the beginning of the seventies. Three films are used to illustrate the construction of this new model and the principal attributes of this unusal visibility of the Afro- American experience: Cotton Comes to Harlem (Ossie Davies, 1970), Sweet Sweetback’s Baadasssss Song (Melvin Van Peebles, 1971) and Shaft (Gordon Parks, 1971). Through a comparison of the way in which the Afro-American identity was represented in these films and in the previous decades, this text attempts to demostrate how and why the Hollywood industry changed its attitude towards the Afro-American community.Keywords: Afro-American identity, black filmmakers, blaxploitation, Cotton Comes to Harlem, Sweet Sweetback’s Baadasssss Song, Shaft, Ossie Davies, Melvin Van Peebles, Gordon Parks.
Association of Chest Radiography With Outcomes in Pediatric Pneumonia: A Population-Based Study
Authors: Geanacopoulos Alexandra T. , Neuman Mark I. , Lipsett Susan C. , Monuteaux Michael C. , Michelson Kenneth A. 
Published: June 2023

OBJECTIVE
Chest radiograph (CXR) is often performed for the evaluation of community-acquired pneumonia (CAP) in the ED setting. We sought to evaluate the association of undergoing CXR with 7-day hospitalization after emergency department (ED) discharge among patients with CAP.

METHODS
This was a retrospective cohort study including children 3 months to 17 years discharged from any ED within 8 states from 2014 to 2019. We evaluated the association of CXR performance with 7-day hospitalization at both the patient and ED levels using mixed-effects logistic regression models accounting for markers of illness severity. Secondary outcomes included 7-day ED revisits and 7-day hospitalization with severe CAP.

RESULTS
Among 206 694 children with CAP, rates of 7-day ED revisit, hospitalization, and severe CAP were 8.9%, 1.6%, and 0.4%, respectively. After adjusting for illness severity, CXR was associated with fewer 7-day hospitalizations (1.6% vs. 1.7%, adjusted odds ratio: [aOR] 0.82, 95% confidence interval [CI]: 0.73–0.92). CXR performance varied somewhat between EDs (median 91.5%, IQR: 85.3%–95.0%). EDs in the highest quartile had fewer 7-day hospitalizations (1.4% vs 1.9%, aOR: 0.78, 95% CI: 0.65-0.94), ED revisits (8.5% vs 9.4%, aOR: 0.88, 95% CI: 0.80–0.96) and hospitalizations for severe CAP (0.3% vs. 0.5%, aOR: 0.70, 95% CI: 0.51–0.97) as compared to EDs with the lowest quartile of CXR utilization.

CONCLUSIONS
Among children discharged from the ED with CAP, performance of CXR was associated with a small but significant reduction in hospitalization within 7 days. CXR may be helpful in the prognostic evaluation of children with CAP discharged from the ED.
Teaching Concerns in Higher Education: Impact of Covid-19 in Pedagogy
Authors: Alam Sohaib , Hameed Ansa 
Published: June 2023

Thesis. The present study aims to explore the impact of Covid-19 on higher education and identify the different problems faced by pedagogues around the globe. It compares the outcomes and comments from both established and developing countries to understand the change in pedagogical procedures.
Concept. The desire for social isolation that was unheard of until the 20th and 21st centuries became a catchall word during the pandemic. For educational institutions, the governments’ emergency measures to switch from traditional classroom settings to virtual alternatives generated important opportunities and problematic obstacles.
Results and conclusion. The study was conducted thorough research of Covid-19's broad effects on pedagogical practices in higher education, from the viewpoints of both instructors and learners. An analysis of diverse secondary materials was carried out and conclusions were derived accordingly. The findings show that the pandemic caused distinct problems for different populations depending on selected criteria that were explored and emphasised in the proposed study.
Originality. The study has thoroughly analysed the ideas, challenges, of online educational pedagogy to identify the effectiveness and challenges. The main research contribution is the finding that asserts the promise of technology and the challenges that students encounter when learning through digital processes.