bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factors related to renal deterioration in children and young adults with spina bifida: A longitudinal study using dimercaptosuccinic acid scans
Authors: Yamazaki Yuichiro , GOHBARA AYAKO , Eura Rumiko , Nishi Morihiro , Nishikawa Tomomi , Yamamoto Koji 
Published: January 2023

Abstract
Study Design: Retrospective, cohort study
Objectives: First, to investigate the prevalence of new DMSA abnormalities by age in patients with spina bifida, and second, to evaluate the age differences in risk factors for new DMSA abnormalities.
Setting: Children’s hospital in Yokohama, Japan
Methods: All patients with spina bifida requiring clean intermittent catheterization who visited from 2009 to 2021 were enrolled. Inclusion criteria consisted of having at least two DMSA scans performed at age ≤12 years and ≥13 years. Patients with no sequential data from video urodynamic studies were excluded. Risk factors for new DMSA abnormalities were evaluated in two different growth stages (age ≤12 years, age ≥13 years).
Results Fifty-seven patients with a median follow-up of 18 years were included. At the end of the study, 22 patients (39%) had DMSA abnormalities. The number of patients having new DMSA abnormalities in childhood (age ≤12 years) and in young adulthood (age ≥13 years) was 10 (18%) and 12 (21%), respectively. After the LASSO logistic analysis, three variables (maximum detrusor pressure, vesicoureteral reflux, and bladder trabeculation) were identified as factors related to new DMSA abnormalities in children. On the other hand, vesicoureteral reflux was the only related factor in young adults.
Conclusions: In children with spina bifida, there was no age tendency in the development of new DMSA abnormalities. Vesicoureteral reflux was related to new DMSA abnormalities in both childhood and young adulthood. However, video urodynamics parameters were related to new DMSA abnormalities only in childhood.
Residual-based a posteriori error analysis of an ultra-weak discontinuous Galerkin method for nonlinear second-order initial-value problems
Authors: Baccouch Mahboub 
Published: January 2023

Abstract
Note: Please see pdf for full abstract with equations.
In this paper, we propose and analyze implicit residual-based a posteriori error estimates for the ultra-weak discontinuous Galerkin (UWDG) method for nonlinear second-order initial-value problems for ordinary differential equations of the form u′′ = ƒ(x, u). We prove that the UWDG error on each element can be split into two parts. The significant part is proportional to the (p + 1)-degree polynomial (1 − ξ)2P2,0p−1(ξ), ξ ∈ [−1, 1], where P2,0p−1(ξ) is the (p − 1)-degree Jacobi polynomial, when piecewise polynomials of degree at most p ≥ 2 are used. The second part of the error converges with order p + 2 in the L2-norm. These results allow us to construct a posteriori UWDG error estimates. The proposed residual-based a posteriori error estimators of this paper are reliable, efficient, and are obtained by solving a local problem with no side conditions on each element. Furthermore, we prove that, for smooth solutions, these a posteriori error estimates converge to the exact errors in the L2-norm under mesh refinement. The order of convergence is proved to be p + 2. Finally, we prove that the global effectivity index converges to unity at O(h) rate. Several numerical experiments are provided to validate the theoretical results.
AMS subject classifications (2020)}: 65L05, 65L20, 65L50, 65L60, 65L70.
Ambulance referral of more than 2 hours could result in a higher prevalence of medical- devices-related pressure injuries (MDRPIs) with different characteristics compared to the inpatient setting: A descriptive observational study
Authors: luo zhenyu , Liu Sihui , Yang Linhe , Zhong Shuyan , Bai Lihua 
Published: January 2023

Abstract
Background
Medical device-related pressure injuries(MDRPI) are prevalent and attracting more attention. During ambulance transfer, the shear force caused by braking and acceleration; extensive medical equipment crowed in a narrow space add external risk factors for MDRPIs. However, there is insufficient research on the relationship between MDRPIs and ambulance transfers. This study aims to clarify the prevalence and characteristics of MDRPI during ambulance transfer.
Method
A descriptive observational study was conducted with convenience sampling. Before starting the study, six PI specialist nurses certified by the Chinese Nursing Association trained emergency department nurses for three MDRPI and Braden Scale sessions, one hour for each session. Data and images of PIs and MDRPIs are uploaded via the OA system by emergency department nurses and reviewed by these six specialist nurses. The information collection begins on 1 July 2022 and ends on 1 August 2022. Demographic and clinical characteristics and a list of medical devices were collected by emergency nurses using a screening form developed by researchers.
Results
One hundred one referrals were eventually included. The mean age of participants was (58.3±11.69) years, predominantly male (67.32%, n=68), with a mean BMI of 22.48±2.2. The mean referral time among participants was 2.26 ± 0.26 hours, the mean BRADEN score was 15.32 ± 2.06, 53.46% (n=54) of participants were conscious, 73.26% (n=74) were in the supine position, 23.76% (n=24) were in the semi-recumbent position, and only 3 (2.9%) were in the lateral position. Eight participants presented with MDRPIs, and all MDRPIs are stage 1. Patients with spinal injuries are most prone to MDRPIs (n=6). The jaw is the area most prone to MDRPIs, caused by the cervical collar (40%, n=4), followed by the heel (30%, n=3) and nose bridge (20%, n=2) caused by the respiratory devices and spinal board.
Conclusion
During long ambulance referrals, the prevalence of MDRPIs is higher than in some inpatient settings. The characteristics and related high-risk devices are also different. The prevention of MDRPIs during ambulance referrals deserves more research.
Correlation between prognostic indicator FGFR1 and immune infiltrates in non‑small cell lung cancer
Authors: Wang Xianhui , Li Xihua , Liu Dandan , Tang Zhiping 
Published: January 2023

Abstract
Background
Fibroblast growth factor receptor 1(FGFR1) plays a indispensable role in the tumorigenesis and therapy. However, the relationship of FGFR1 in the prognosis and immune infiltration remains to be elucidated.
Methods
FGFR1 expression was analyzed in different databases, respectively. Clinicopathological parameters and survival datas were analyzed by Kaplan-Meier plotter. The correlations between FGFR1 and immune infiltrates were conducted by Tumor Immune Estimation Resource (TIMER). Genetic alterations of FGFR1 and DNA methylation were assessed by cBioPortal and MethSuev. FGFR1 co-expressed and functional networks were analyzed by LinkedOmics in nonsmall cell lung cancer (NSCLC).
Results
FGFR1 expression was significantly lower in NSCLC than normal tissues, and high FGFR1 significantly correlated with favorable overall survival (OS) in lung squamous cell carcinomas (LUSC). FGFR1 can predict tumor prognosis independently of other factors in OS by Cox analyses. Moreover, FGFR1 expression was significantly correlated with the infiltrating multiple tumor immune cell markers both in NSCLC. Additonaly, the gene alteration and prognostic value of the DNA methylation patterns of FGFR1 in NSCLC were carried out. Furthermore, a functional network analysis confirmed the function of FGFR1 in regulating tumorigenesis and vasculogenesis.
Conclusions
FGFR1 may be used as a biomarker for prognosis and evaluating immune infiltration in NSCLC.
Interrelation between the lipid accumulation product index and diabetic kidney disease in patients with type 2 diabetes mellitus
Authors: Tang Min , Yao Shuangshuang , Zhen Qin , Wei Xiaohui , Cao Han , Tan Yitong , Liu Fang , Wang Yufan , Peng Yongde , Fan Nengguang 
Published: January 2023

Abstract
Aims: The purpose of this study was to determine the relation between the lipid accumulation product index (LAPI) and diabetic kidney disease (DKD) in patients with type 2 diabetes mellitus (T2DM).
Methods: Herein, 931 patients were enrolled and their data were collected. Then the interrelation between LAPI and DKD was assessed using multivariate logistic regression analyses (LRAs) and by a restricted cubic spline (RCS). Receiver operating characteristic (ROC) curves were plotted to compare the performance of discrepant indicators of abdominal obesity (AO) in predicting DKD.
Results: After adjusting for several confounders, the odds ratio for DKD was increased evidently in the third LAPI tertile compared with that in the first LAPI tertile. In addition, the RCS revealed a positive interrelationbetween LAPI and DKD. As illustrated by ROC curves, LAPI showed better performance in predicting DKD than the other indicators.
Conclusions: LAPI is positively linked with DKD, so LAPI may be a suitable indicator for clinically screening patients at risk of DKD.
Effects of carrimycin on biomarkers of inflammation and immune function in tumor patients with sepsis: a multicenter double-blind randomized controlled trial
Authors: Nan Chuanchuan , Zhang Xiaowu , Huang Wei , Zhu Biao , Zhao Jianghong , Lu Song , Xian Lewu , Liu Kaizhong , Ma Gang , Yang Wei , Huang Mingguang , Zhou Dongmin , Zhang Ming , Duan Yan , Wu Guixin , Jiang Zhengying , Zhang Li , He Xinrong , Chen Yuhong , Xing Xuezhong , Wang Changsong , Wang Donghao , Yu Kaijiang 
Published: January 2023

Abstract
Background

With progress in tumor treatments, patient survival has been significantly extended; nevertheless, tumors and tumor treatments increase the risk of sepsis. Carrimycin may act as an immune-regulating treatment for tumor-related sepsis. We aimed to evaluate whether carrimycin regulates inflammation and immune function in tumor patients with sepsis.

Methods

We conducted a multicenter, randomized, placebo-controlled, double-blind clinical trial involving tumor patients with sepsis. The participant inclusion criteria were as follows: 1. age ≥ 18 and ≤ 75 years old; 2. condition consistent with sepsis 3.0 diagnostic criteria; 3. SOFA score of 2–13; and 4. patients with malignant tumors. Enrolled patients were assigned to either carrimycin treatment (400 mg/day) or placebo treatment (400 mg/day) orally once a day for 7 days. The primary outcome was immune-related indicators.

Results

A total of 120 patients were randomized, of whom 47 were assigned to receive carrimycin and 52 placebo. In immune and inflammation indicators, the HLA-DR and CD8 + T-cell levels showed promising trends, although there was no significant difference between the carrimycin and placebo groups (P > 0.05). In the CD4 < 38.25 subgroup, the HLA-DR level of the carrimycin group was significantly better than that of the placebo group at 1 day after administration (P = 0.023). In the CD8 < 25.195 subgroup, the degree of decrease in IL-8 in the carrimycin group was significantly higher than that in the placebo group at 1 (P = 0.027) and 3 (P = 0.034) days after administration. The CD8 + T-cell subset level of the carrimycin group was significantly better than that of the placebo group at 3 (P = 0.027) and 5 (P = 0.035) days after administration. The levels of SOFA, APACHE II, PCT and CRP were significantly reduced by carrimycin intervention. No serious adverse events were recorded.

Conclusions

In tumor patients with sepsis, especially those with immunocompromised function, carrimycin regulates the immune status by increasing the HLA-DR level and plays an anti-infective role to improve the severity of the disease but does not affect 28-day all-cause mortality.
The trial was registered in the Chinese Clinical Trial Registry (http://www.chictr.org.cn) with the number ChiCTR2000032339 on April 26, 2020.
LINC01134 promotes the progression of colorectal cancer through enhancing SLC1A5 mRNA stability
Authors: Li Yao , Jinxiu Wu , Nailing Wang 
Published: January 2023

Abstract
Colorectal cancer (CRC) is one of the most common malignant tumors with a poor prognosis. Long noncoding RNAs (lncRNAs) were reported to play a vital role in regulating the progression of cancers and had been become the focus of intense research in cancer biology. Meanwhile, LINC01134 functions as an oncogene in many cancers, but the possible roles and mechanisms in the occurrence and development of CRC are still unclear. This study aimed to explore the biological mechanism of LINC01134 in the progression of CRC. First, we found LINC01134 was highly expressed in CRC tissues and associated with worse clinical stages and poor prognosis, which was in line with that in CRC cell lines. Functional experiments indicated that silencing of LINC01134 attenuated CRC cells proliferation and induced the apoptosis both in vitro and in vivo. Mechanistically, weighted gene co-expression analysis identified that LINC01134 was positively related to SLC1A5, which was also upregulated and associated with poor prognosis in CRC. Going further, RNA–RNA interaction in vitro analysis and analysis of mRNA stability indicated that LINC01134 could directly bind to SLC1A5 mRNA and enhance SLC1A5 mRNA stability. Notably, silencing of SLC1A5 could partly reverse the promotion effect of LINC01134 overexpression on proliferation and the inhibitory effect on cells apoptosis in CRC cells. Our findings showed that LINC01134 acted as an oncogene in CRC via directly binding to SLC1A5 mRNA and enhancing SLC1A5 mRNA stability, which suggested that LINC01134 might act as a promising therapeutic target for CRC.
Power for clinical and statistical significance
Authors: Bishara Samuel 
Published: January 2023

Abstract
This paper explores the implication of utilising statistical power for superiority, rather than equivalence, in clinical trials, with a specific illustration for unpaired continuous parametric variables using a simple adjustment to the power calculation which has been previously described. The advantages of such an approach, is that it separates the notion of the likely difference between two groups (the effect size) and the minimum clinically significant difference, without which logically inconsistent positions might be held. In the post hoc scenario this approach can shed further light on the value of undertaking further studies, which is not apparent form the standard power calculation which purely reflects the obtained p-value. The trend for increased trial size and the mirror approach of non-inferiority studies, that is sometimes adopted, implies a trend for overall reduction in the clinical effectives of newer studies, which could be countered by powering for superiority.
Pollution characteristics and Groundwater ion source analysis of the last 20 years in a semi-arid region of northwest China
Authors: Liu Yang , Li Fengjie , Ayyamperumal Ramamoorthy , Wang Wengfang 
Published: January 2023

Abstract
Groundwater hydrochemistry analysis can be used to assess the general quality of groundwater as well as how groundwater has changed over time and how anthropogenic activities have affected it. In this study, total dissolved solids (TDS), pH and 10 ions (Na+, K+, Mg2+, Ca2+, Cl-, SO42-, NO3-, CO32-, HCO3- and F-) were measured at 34 sites in the main urban area of Lanzhou, a major city in northwest China, by means of boreholes in 2002 and 2022 respectively. The evolution of groundwater chemistry in the region over a twenty-year period due to mineral weathering and dissolution, ion exchange, and urban activity was explained using a geochemical model, chlor-alkalinity index, and correlations between Cl- and NO3- in the urban area. In addition, statistical methods were used to analyze groundwater ion sources and compare the ion source characteristics over a twenty-year period to reveal the extent to which urbanization and industrialization have influenced groundwater. The results show that overall groundwater quality in the area has improved over the last two decades, with little change in groundwater chemistry type. Furthermore, the chemical ions in groundwater were influenced less by industrialization and more by urban anthropogenic activities, which include not only urban wastewater discharge but also the rapid reduction of groundwater levels due to extensive urban construction activities. It is recommended that groundwater quality be further improved through enhanced municipal management measures, which should focus on the threat posed by groundwater precipitation in addition to considering the control of sewage discharge.
Second order universal filter using voltage follower topology
Authors: Almutairi Fatima , Almutairi Reem 
Published: January 2023

Abstract
In this paper, a voltage mode multi input single output second order universal filter based on the voltage follower concept is proposed. The MISO filter offers low-pass, band-pass, high-pass, all-pass and band-stop filters which is digital selecting by the input. The filter design consists of positive feedback and feed forwards path to implement a universal filter. The positive feedback is used to increase the quality factor of the filter. The feed forwards path is necessary to create zeros for the band-stop and high-pass filter. The proposed filter has many advantages such as an electronically tunable filter response, low power consumption and area. The performance of the proposed design has been tested using CMOS 130nm process technology.
Gastrointestinal helminths of two Storm Petrel species, Oceanites oceanicus and Fregetta tropica, from Antarctica
Authors: Fusaro Bruno , Lorenti Eliana , Panisse Guillermo , Fornillo Valentina , Fuentes Lautaro , Libertelli Marcela , Ansaldo Martin , Diaz Julia I. 
Published: January 2023

Abstract
Although knowledge about parasitic diseases in Antarctic birds is scarce, an increasing number of studies are currently being carried out in this area. The importance of the host-parasite relationship in Antarctic seabirds is key to understanding trophic ecology and epidemiology of infection diseases, especially in those birds with extensive migratory routes that can act as reservoirs and distributors of diseases. This study aims to provide information on helminths of two Storm Petrel species, the Wilson’s storm-petrel Oceanites oceanicus and the Black-bellied storm-petrel Fregetta tropica. Twenty individuals were analysed: 18 O. oceanicus (8 adults, 10 chicks) and 2 F. tropica (adults); 89% of the O. oceanicus were parasitized with the nematode Stegophorus macronectes, whereas 100% of F. tropica was parasitized by at least one of three parasite species identified: S. macronectes, Seuratiasp., and Tetrabothrius sp. The low richness of parasites observed is associated with a stenophagic diet. However, a clear difference is observed between both species related to a higher fish ingestion by F. tropica, unlike O. oceanicus with a higher ingestion of krill.
Glucocorticoid nanoformulations relieve chronic pelvic pain syndrome and may alleviate depression in mice
Authors: Yang Yang , Hu Ruimin , Zheng Jun , Wang Qianmei , Xu Senlin , Zhou Zhansong , Zhang Dinglin , Shen Wenhao 
Published: January 2023

Abstract
Background
Chronic pelvic pain syndrome (CPPS) is a typical symptom of chronic prostatitis (CP) in males that may cause abnormal urination, sexual dysfunction, or depression and significantly affect the quality of life of the patient. Currently, there is no effective treatment for CPPS due to its recurrence and intractability. For synergistic CPPS therapy, we developed pH/reactive oxygen species (ROS) dual-responsive dexamethasone (Dex) nanoformulations using a ROS-responsive moiety and phytochemical modified α-cyclodextrin (α-CD) as the carrier.
Results
Dex release from the nanoformulations can be controlled in acidic and/or ROS-rich microenvironments. The fabricated Dex nanoformulations can also be efficiently internalized by lipopolysaccharide (LPS)-stimulated macrophages, prostatic epithelial cells, and stromal cells. Moreover, the levels of proinflammatory factors (e.g., TNF-α, IL-1β, and IL-17A) in these cells were significantly decreased by Dex nanoformulations treatment through the release of Dex, phytochemical and elimination of ROS. In vivo experiments demonstrated notable accumulation of the Dex nanoformulations in prostate tissue to alleviate the symptoms of CPPS through the downregulation of proinflammatory factors. Interestingly, depression in mice may be relieved due to alleviation of their pelvic pain.
Conclusion
We fabricated Dex nanoformulations for the effective management of CPPS and alleviation of depression in mice.
The Relationship Between Alpha Power and Heart Rate Variability Commonly Seen in Various Mental States
Authors: Kawashima Tomoya , Shiratori Honoka , Amano Kaoru 
Published: January 2023

Abstract
Although researchers have widely explored the relationship between EEG and heart rate variability (HRV), the results are not always consistent mainly due to the variety of tasks. In particular, several factors, such as mental fatigue and sleepiness, can affect the alpha power, which makes it difficult to obtain a direct relationship between alpha and heart rate activities. This study investigates the brain–heart interplay that is consistently observed in various mental states: listening to music and resting. To eliminate the indirect effects of mental states on alpha power, subjective fatigue and sleepiness in the resting condition and their emotional valence and arousal in the music condition were measured. A partial correlation analysis in the music condition, which excluded the indirect effects of emotional valence and arousal level, showed a positive correlation between the power of the occipital alpha2 component (10-12 Hz) and nHF, a measure of parasympathetic activity. In a similar vein, a partial correlation analysis in the resting condition, excluding subjective fatigue and sleepiness effects, showed a positive correlation between the occipital alpha2 component and nHF. These results indicate a brain–heart interplay that is frequently observed in various subjective states and that still exists after eliminating the effects of other variables.
Framework for the Full N-Body Problem in SE(3) and its Reduction to the Circular Restricted Full Three-Body Problem
Authors: Nazari Morad , Canales David , McCann Brennan , Butcher Eric , Howell Kathleen 
Published: January 2023

Abstract
A novel, compact formalism of rigid body motion dynamics is presented in a general reference frame based on the geometric mechanics framework. This formalism, proposed on the special Euclidean space (SE(3)) of the Lie group, naturally accounts for the orbit/attitude coupling due to the gravitational moments and forces. It is demonstrated that the structure of the rigid body dynamics equations is preserved in different coordinate frames. Then, using the expression of gravitational potential, this global framework is applied to the circular restricted full three-body problem (CRF3BP) of a near-rectilinear halo orbit (NRHO) similar to that of Gateway, where the equations are uniquely provided in the body frame of the spacecraft and the barycentric rotating frame. For the sake of propagation and consistency with the classical circular restricted three-body problem (CR3BP), the equations of the CRF3BP are also presented in a non-dimensional form. Trajectories computed with different inertia tensors are compared with those obtained using the traditional equations of motion of a point-mass spacecraft subject to the gravitational fields of two larger primaries. The comparison between CRF3BP and CR3BP suggests: (a) the need for computation of customized families of halo orbits considering inertia properties of each spacecraft; and (b) the use of attitude-only control for station-keeping in future NRHO missions to reduce station-keeping costs which would otherwise be relatively large if the point-mass approximation were used.