bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prognostic value of the S100 calcium-binding protein family members in hepatocellular carcinoma
Authors: Wei Ran , Feng Ou Qi , Hui Yao Ze , Huang Xiaohui , Ping Li Sheng 
Published: May 2023

Abstract
Hepatocellular carcinoma (HCC) remains a crucial public health problem around the world, and the outlook remains bleak. More accurate prediction models are urgently needed because of the great heterogeneity of HCC. The S100 protein family contains over 20 differentially expressed members, which are commonly dysregulated in cancers. In the present study, we analyzed the expression profile of S100 family members in patients with HCC based on the TCGA database. A novel prognostic risk score model, based on S100 family members, was developed using the least absolute shrinkage and selection operator regression algorithm, to analyze the clinical outcome. Our prediction model showed a powerful predictive value (1-year AUC: 0.738; 3-year AUC: 0.746; 5-year AUC: 0.813), while two former prediction models had less excellent performances than ours. And the S100 family members-based subtypes reveal the heterogeneity in many aspects, including gene mutations, phenotypic traits, tumor immune infiltration, and predictive therapeutic efficacy. We further investigated the role of S100A9, one member with the highest coefficient in the risk score model, which was mainly expressed in para-tumoral tissues. Using the Single-Sample Gene Set Enrichment Analysis algorithm and immunofluorescence staining of tumor tissue sections, we found that S100A9 may be associated with macrophages. These findings provide a new potential risk score model for HCC and support further study of S100 family members in patients, especially S100A9.
Durchführbarkeit und Ergebnisse einer psychotherapeutischen Gruppentherapie für Patienten mit Fatigue sowie emotionalen und kognitiven Störungen in Folge einer COVID-19-Erkrankung
Authors: Schilling Thomas M. , Klein Johanna F. , Aschenbrenner Steffen , Drengner Anne , Randerath Jennifer , Weisbrod Matthias 
Published: May 2023

ZUSAMMENFASSUNGBis zu 10 % aller symptomatisch Infizierten berichten noch Monate nach einer COVID-19-Erkrankung von anhaltenden gesundheitlichen Beeinträchtigungen. Auf neuropsychiatrischem Fachgebiet gehören Fatigue sowie kognitive und emotionale Störungen zu den häufigsten Beschwerden. Evidenzbasierte Therapiemethoden für Post-COVID-Patienten mit diesen Beeinträchtigungen fehlen. In der vorliegenden Studie wurde die Durchführbarkeit eines neu entwickelten Gruppentherapieprogrammes für Patienten mit Fatigue, emotionalen und kognitiven Störungen in Folge einer COVID-19-Erkrankung untersucht.24 Patienten mit den Diagnosen ICD-10 F06.8 und U0.09 nahmen im Mittel 13 Monate nach ihrer akuten COVID-Erkrankung an der Gruppentherapie teil. Vor und nach der Gruppentherapie wurden die Teilnehmer klinisch und neuropsychologisch untersucht. Die Gruppentherapie erfolgte online und bestand aus 8 wöchentlichen Sitzungen, die psychoedukative und psychotherapeutische Elemente sowie therapeutische Übungen zu den Themen Fatigue und Pacing, Achtsamkeit, psychische Störungen, kognitive Fähigkeiten sowie Sport bei Post-COVID umfassten. Die Teilnahmequote an der Gruppe war mit 7,25 von 8 Sitzungen hoch und die Teilnehmer bewerteten die Gruppentherapie als überwiegend hilfreich (M = 7,78 von 10 Punkten). Über den Zeitraum der Untersuchung hinweg besserte sich bei den Patienten die selbst eingeschätzte Fatigue, Alltagskompetenz, Depressivität und die subjektiv wahrgenommene kognitive Leistungsfähigkeit sowie die objektiv erfasste Leistung in den neuropsychologischen Aufmerksamkeitstests.Das neu entwickelte Gruppentherapieprogramm für Patienten mit Fatigue sowie emotionalen und kognitiven Störungen in Folge einer Infektion mit SARS-CoV-2 wird gut angenommen, positiv bewertet und ist online durchführbar.
Versorgung gerontopsychiatrischer Patienten am Lebensende
Authors: Seethaler Magdalena , Just Sandra , Stolarek Johann , Hecker Cordula , Rahaus Janina , Hagedorn Udo , Stötzner Philip , Bermpohl Felix , Brandl Eva Janina 
Published: May 2023

ZUSAMMENFASSUNGPatienten mit psychischen und terminal somatischen Erkrankungen stellen eine klinische Herausforderung dar. Oft führt die psychiatrische Symptomatik zu eingeschränkter intensiver/palliativmedizinischer Versorgung. Bislang wurden kaum Versorgungsansätze für psychiatrisch kranke Patienten am Lebensende publiziert.Vorliegende Publikationen werden zunächst in einem narrativen Review zusammengefasst. Im Anschluss wird das Versorgungskonzept in der Psychiatrischen Universitätsklinik der Charité im St. Hedwig-Krankenhaus in Berlin vorgestellt. Bestandteile sind unter anderem die Etablierung einer ethischen Visite sowie eines strukturierten Therapieplans in den Klinikalltag, um eine individualisierte Begleitung in dieser komplexen Erkrankungs- und Versorgungssituation zu ermöglichen.
Therapierefraktäre Epilepsia partialis continua während einer SARS-CoV-2-Infektion
Authors: Kozian Ralf , Chaaban Alexandra 
Published: May 2023

ZUSAMMENFASSUNGWir berichten über eine 87-jährige Patientin, die vor 2 Jahren an einem Ovarialtumor erkrankt war. Therapeutisch war eine beidseitige Adnexektomie erfolgt. 2 Jahre später trat bei der Patientin eine Epilepsia partialis continua (Kojewnikoff-Epilepsie) auf bei gleichzeitig vorliegendem paraneoplastischem Syndrom mit positivem Anti-Yo-Nachweis im Liquor und während einer SARS-CoV-2-Infektion.
The Prevalence of Confidential Content in Adolescent Progress Notes Prior to the 21st Century Cures Act Information Blocking Mandate
Authors: Bedgood Michael , Rabbani Naveed , Brown Conner , Goldstein Rachel , Carlson Jennifer L. , Steinberg Ethan , Powell Austin , Pageler Natalie M. , Morse Keith 
Published: May 2023

Abstract
Background The 21st Century Cures Act information blocking final rule mandated the immediate and electronic release of health care data in 2020. There is anecdotal concern that a significant amount of information is documented in notes that would breach adolescent confidentiality if released electronically to a guardian.
Objectives The purpose of this study was to quantify the prevalence of confidential information, based on California laws, within progress notes for adolescent patients that would be released electronically and assess differences in prevalence across patient demographics.
Methods This is a single-center retrospective chart review of outpatient progress notes written between January 1, 2016, and December 31, 2019, at a large suburban academic pediatric network. Notes were labeled into one of three confidential domains by five expert reviewers trained on a rubric defining confidential information for adolescents derived from California state law. Participants included a random sampling of eligible patients aged 12 to 17 years old at the time of note creation. Secondary analysis included prevalence of confidentiality across age, gender, language spoken, and patient race.
Results Of 1,200 manually reviewed notes, 255 notes (21.3%) (95% confidence interval: 19–24%) contained confidential information. There was a similar distribution among gender and age and a majority of English speaking (83.9%) and white or Caucasian patients (41.2%) in the cohort. Confidential information was more likely to be found in notes for females (p < 0.05) as well as for English-speaking patients (p < 0.05). Older patients had a higher probability of notes containing confidential information (p < 0.05).
Conclusion This study demonstrates that there is a significant risk to breach adolescent confidentiality if historical progress notes are released electronically to proxies without further review or redaction. With increased sharing of health care data, there is a need to protect the privacy of the adolescents and prevent potential breaches of confidentiality.
Computed Tomography Scan of the Aorta to Predict Type B Aortic Dissection
Authors: Lee Han , Zhou Qing , Zhang Haitao , Jin Min , Tang XinLong , Li Kai , Tuoerxun Tayierjiang 
Published: May 2023

Abstract
Background The purpose of this study is to find the high-risk morphological features in type B aortic dissection (TBAD) population and to establish an early detection model.
Methods From June 2018 to February 2022, 234 patients came to our hospital because of chest pain. After examination and definite diagnosis, we excluded people with previous cardiovascular surgery history, connective tissue disease, aortic arch variation, valve malformation, and traumatic dissection. Finally, we included 49 patients in the TBAD group and 57 in the control group. The imaging data were retrospectively analyzed by Endosize (Therevna 3.1.40) software. The aortic morphological parameters mainly include diameter, length, direct distance, and tortuosity index. Multivariable logistic regression models were performed and systolic blood pressure (SBP), aortic diameter at the left common carotid artery (D3), and length of ascending aorta (L1) were chosen to build a model. The predictive capacity of the models was evaluated through the receiver operating characteristic (ROC) curve analysis.
Results The diameters in the ascending aorta and aortic arch are larger in the TBAD group (33.9 ± 5.9 vs. 37.8 ± 4.9 mm, p < 0.001; 28.2 ± 3.9 vs. 31.7 ± 3.0 mm, p < 0.001). The ascending aorta was significantly longer in the TBAD group (80.3 ± 11.7 vs. 92.3 ± 10.6 mm, p < 0.001). Besides, the direct distance and tortuosity index of the ascending aorta in the TBAD group increased significantly (69.8 ± 9.0 vs. 78.7 ± 8.8 mm, p < 0.001; 1.15 ± 0.05 vs. 1.17 ± 0.06, p < 0.05). Multivariable models demonstrated that SBP, aortic diameter at the left common carotid artery (D3), and length of ascending aorta (L1) were independent predictors of TBAD occurrence. Based on the ROC analysis, area under the ROC curve of the risk prediction models was 0.831.
Conclusion Morphological characteristic including diameter of total aorta, length of ascending aorta, direct distance of ascending aorta, and tortuosity index of ascending aorta are valuable geometric risk factors. Our model shows a good performance in predicting the incidence of TBAD.
Sudden braking and turning with a two-field potential bump: primordial black hole formation
Authors: Fu Chengjie , Chen Chao 
Published: May 2023

Abstract
We investigate the amplification of curvature perturbations in a two-field inflation model
featuring a Gaussian potential bump. When the inflaton encounters a potential bump along the
inflationary trajectory, its rolling speed is generally reduced, potentially causing a violation
of the slow-roll condition. Consequently, the original decaying modes of comoving curvature
perturbations during the slow-roll phase start growing, and lead to enhanced small-scale density
perturbations which can produce amounts of primordial black holes (PBHs) and associated
scalar-induced gravitational waves. In addition, inflaton also undergoes sudden turnings at the
encounter of the Gaussian potential bump, which is insignificant to the overall curvature power
spectrum due to the short duration of these turns. Our paper offers a simple example of the
extension of a bump-like potential for PBH formation in a single-field inflation to a two-field
case, which helps alleviate the fine-tuning of initial conditions to some extent.
Possible relationship between initial conditions for inflation and past geodesic incompleteness of the inflationary spacetime
Authors: Kaganovich Alexander B. 
Published: May 2023

Abstract
According to the Borde-Guth-Vilenkin (BGV) theorem an expanding region of spacetime cannot
be extended to the past beyond some boundary ℬ. Therefore, the inflationary universe
must have had some kind of beginning. However, the BGW theorem says nothing about the boundary
conditions on ℬ, or even about its location. Here we present a single-scalar field
model of the Two-Measure Theory, where the non-Riemannian volume element Υ d
4
x is
present in the action. As a result of the model dynamics, an upper bound φ
0 of
admissible values of the scalar field φ appears, which sets the position of ℬ
in the form of a spacelike hypersurface Υ(x) = 0 with a boundary condition:
Υ → 0+ as φ → φ
0
-. A detailed study has
established that if the initial kinetic energy density ρ
kin
(in) prevails over initial
gradient energy density ρ
grad
(in) then there is an interval of initial values
φ
in
(min) ≤ φ
in < φ
0, where ρ
kin
(in) and
ρ
grad
(in) cannot exceed the potential energy density and hence the initial conditions
necessary for the onset of inflation are satisfied. It is shown that under almost all possible
left-handed boundary conditions on ℬ, that is where Υ → 0-, the
metric tensor in the Einstein frame has a jump discontinuity on ℬ, so the Christoffel
connection coefficients are not defined on the spacelike hypersurface Υ = 0. Thus, if
φ
in
(min) ≤ φ
in < φ
0 and ρ
kin
(in) > ρ
grad
(in), then
there was an inflationary stage in the history of our Universe and the congruence of timelike
geodesics cannot be extended to the past beyond the hypersurface Υ = 0.
Numerical simulation of the nitrogen boil-off recondensation in hybrid cooling devices for HPGe detectors
Authors: Malgin V. , Vencels J. 
Published: May 2023

Abstract
This paper describes the results of a complex simulation of nitrogen boil-off recondensation in a hybrid cooling device for High Purity Germanium (HPGe) detectors. The OpenFOAM platform-based software was used. The proposed finite-volume axisymmetric 2D model combines cooling processes occurring in the considered three-phase medium, including a liquefier condenser (solid), nitrogen boil-off (gas) and the resulting condensate (liquid). At the beginning of the simulation condenser and gas temperatures are set above the condensation point while the end time is set such that the system reaches a quasi-steady state. For conical and hemispherical condensers, the energy consumption for the following processes occurring in the operating mode such as: condenser cooling; cooling of adjacent boil-off nitrogen vapors; their condensation; the gravity-driven flowing; condensate film subcooling and subsequent partial re-evaporation from its surface are compared. The visualizations of the temperature field of the finite-volume model and the velocity vectors of nitrogen vapors adjacent to the condenser are presented. The calculated integral mass recondensation rates were confirmed experimentally on a commercial hybrid cooling device, taking into account the actual equivalent characteristics of the liquefier on the Stirling cryocooler used.
Increased bioavailability of diosmetin-7-glucoside-γ-cyclodextrin inclusion complex compared with diosmin in Sprague-Dawley rats
Authors: Moriwaki Masamitsu , Kito Kento , Nakagawa Ryo , Kapoor Mahendra P , Matsumiya Yoshiki , Fukuhara Tomohisa , Kobayashi Junya , Satomoto Kensuke , Yamagata Hiroshi , Kuroiwa Yuichi 
Published: May 2023

ABSTRACT
Diosmin (DSN) is found mainly in citrus fruits, and has potent antioxidant effects. This study aimed to evaluate pharmacokinetics of diosmetin-7-glucoside-γ-cyclodextrin (DIOSG-CD) inclusion complex. The area under the curve values from AUC0-24 of DIOSG-CD, prepared by reacting DSN and naringinase with γ-CD, were approximately 800-fold higher than those of DSN following their administration in Sprague-Dawley rats.
qSOFA Score is useful to predict in-hospital mortality and long-term outcomes in patients with acute coronary syndrome
Authors: Devesa Neto V , Correia J , Fiuza J , Santos L F 
Published: May 2023

Abstract

Funding Acknowledgements
Type of funding sources: None.

Introduction
Quick Sequential Organ Failure Assessment (qSOFA) is a bedside score widely used to identify patients at greater risk for a poor outcome outside the intensive care unit. Initially applied in patients with suspected infection, the score has recently emerged as a marker for poor prognosis or mortality across various patient groups.

Aim
To validate the qSOFA score as a predictor of in-hospital mortality and long-term outcomes in acute coronary syndrome (ACS) patients.

Methods
A retrospective analysis of 1296 patients admitted for ACS was performed. qSOFA score evaluates the presence of 3 variables: systolic blood pressure &lt;120mmHg (1 point), respiratory rate ≥22 breaths per min (1 point), and Glasgow coma scale &lt;15 (1 point). The score derived from these variables allowed the classification of patients into two risk categories: low risk (LR) (&lt;2 points) and high risk (HR) (≥2 points). The Mann-Whitney U test was used for median comparison between groups. In addition, Kaplan-Meier survival plot was used to evaluate the predictive power of qSOFA score on in-hospital mortality and 12-month mortality (12MM).

Results
Mean age 69,1±13years; 70% were male. The mean time of hospitalization was 7,4±5days. 34% had a diagnosis of ST-elevation myocardial infarction (STEMI). Mean left ventricular ejection fraction (LVEF) was 56,4±14,6%. Global in-hospital mortality was 8%. qSOFA was calculated, and the population was divided into 2 groups: 78% had low risk (qSOFA &lt;2) and 6% had high risk (qSOFA ≥2). HR group defined by qSOFA was significantly associated with in-hospital mortality (28% vs 8%; p&lt;0,01, OR: 3,8 CI 95% 2,4;6,2). Kaplan-Meier survival analysis revealed that HR qSOFA was significantly associated with 12MM (p&lt;0,01; 24% vs 7%; 260 vs 321 days until event, χ2 8,2). In logistic regression analysis, LVEF and diagnosis of STEMI did not increase the risk of a higher qSOFA score and in-hospital mortality (p=0,06 and p=0,94). HR group is significantly associated with left main coronary artery disease (12% vs 9%; p&lt;0,01; OR 2,4; CI 95% 1,2;4,9) and in-hospital complications, including arrhythmia, mechanical complications, hemorrhagic events, acute kidney disease and hematological disorders (54% vs 28%; p&lt;0,01; OR 3,0; CI 95% 1,9;4,6).

Conclusion
qSOFA score is associated with higher in-hospital mortality and 12 month-mortality in patients with ACS. Its use may identify patients with an increased risk of mortality, needing specialized care, and a close follow-up.
Temporal trends in Singapore for out-of-hospital cardiac arrest with an initial non-shockable rhythm
Authors: Lim S L , Chan S P , Shahidah N , Ng Q X , Ho A , Arulanandam S , Leong B , Ong M 
Published: May 2023

Abstract

Funding Acknowledgements
Type of funding sources: Public grant(s) – National budget only. Main funding source(s): National Medical Research Council Singapore

Background
Out-of-hospital cardiac arrest (OHCA) with an initial non-shockable rhythm is the predominant form of OHCA in adults, yet outcomes are dismal. We evaluated its 10-year trends in epidemiology and management in Singapore.

Methods
Using the national OHCA registry we studied the trends of 20,844 Emergency Medical Services (EMS)-attended adult OHCA from April 2010 to December 2019. Survival to hospital discharge was the primary outcome. Analyses of the trends and outcomes were performed with linear regression and logistic regression, respectively.

Results
Incidence rates of EMS-attended adult OHCAs increased during the study period, with increasing proportion of adult OHCA being non-shockable OHCA (Figure 1). Compared to shockable OHCA, non-shockable OHCAs were significantly older (median age 71 vs 61 years), had more comorbidities (median Charlson Comorbidity Index 4 vs 3), more likely unwitnessed (46% vs 25%) and residential arrests (77% vs 53%) (all p&lt;0.001); non-shockable OHCAs had longer no-flow time (median 16 vs 13 minutes), and received less bystander cardiopulmonary resuscitation (CPR) (49% vs 61%) and in-hospital interventions (coronary revascularization 1% vs 18%, targeted temperature management (TTM) 3% vs 14%) (all p&lt;0.001). Amongst non-shockable OHCA, age, comorbidities, residential arrests, no-flow time and time to patient increased during the study period, while presumed cardiac etiology decreased; bystander CPR, epinephrine use and TTM increased (all p&lt;0.05) (Figure 2). Survival for non-shockable OHCA did not improve (1% in 2010 to 1.3% in 2019, p=0.107), unlike shockable OHCA (10% to 26%, p&lt;0.001). The likelihood of survival for non-shockable OHCA increased with witnessed arrest (adjusted odds ratio (aOR) 2.281) and bystander CPR (aOR 3.569), but decreased with presumed cardiac etiology (aOR 0.553), epinephrine administration (aOR 0.646), time to patient (aOR 0.938) and comorbidity burden (aOR 0.897). Significant two-way interactions were observed for no-flow time and arrest location with bystander CPR. Cardiac revascularization improved the odds of survival in patients who survived to admission (aOR 2.63).

Conclusion
Singapore saw increasing incidence and interventions for non-shockable OHCA between 2010 and 2019 but limited gains in survival, partly explained by ageing population with increasing comorbidity burden. This contrasts with the improvement in survival for shockable OHCA over the same period. The interactions of location and no-flow time with bystander CPR highlight opportunities to improve pre-hospital care for residential and non-shockable OHCA.
Bridging glycoinformatics and cheminformatics: integration efforts between GlyCosmos and PubChem
Authors: Cheng Tiejun , Ono Tamiko , Shiota Masaaki , Yamada Issaku , Aoki-Kinoshita Kiyoko F , Bolton Evan E 
Published: May 2023

Abstract
The GlyCosmos Glycoscience Portal (https://glycosmos.org) and PubChem (https://pubchem.ncbi.nlm.nih.gov/) are major portals for glycoscience and chemistry, respectively. GlyCosmos is a portal for glycan-related repositories, including GlyTouCan, GlycoPOST, and UniCarb-DR, as well as for glycan-related data resources that have been integrated from a variety of ‘omics databases. Glycogenes, glycoproteins, lectins, pathways, and disease information related to glycans are accessible from GlyCosmos. PubChem, on the other hand, is a chemistry-based portal at the National Center for Biotechnology Information. PubChem provides information not only on chemicals, but also genes, proteins, pathways, as well as patents, bioassays, and more, from hundreds of data resources from around the world. In this work, these 2 portals have made substantial efforts to integrate their complementary data to allow users to cross between these 2 domains. In addition to glycan structures, key information, such as glycan-related genes, relevant diseases, glycoproteins, and pathways, was integrated and cross-linked with one another. The interfaces were designed to enable users to easily find, access, download, and reuse data of interest across these resources. Use cases are described illustrating and highlighting the type of content that can be investigated. In total, these integrations provide life science researchers improved awareness and enhanced access to glycan-related information.