bluuebunny/crossref_metadata_2025_split huggingface dataset:
Humoral response to SARS-CoV-2 mRNA vaccine on in ABO blood type incompatible kidney transplant recipients treated with low-dose rituximab
Authors: Hamaya Tomoko , Hatakeyama Shingo , Yoneyama Tohru , Tobisawa Yuki , Kodama Hirotake , Fujita Takeshi , Murakami Reiichi , Mori Kazuyuki , Okamoto Teppei , Yamamoto Hayato , Yoneyama Takahiro , Hashimoto Yasuhiro , Saitoh Hisao , Narumi Shunji , Tomita Hirofumi , Ohyama Chikara 
Published: September 2023

AbstractWe aimed to evaluate the humoral response after the second and third doses of SARS-CoV-2 mRNA vaccine in ABO blood type incompatible kidney transplant (KT) recipients treated with rituximab. This retrospective study conducted between June 2021 and June 2022 included 131 KT recipients and 154 nontransplant controls who had received mRNA vaccines. We compared the seropositivity (anti-SARS-CoV-2 spike IgG antibody titer ≥ 0.8 U/mL) after the second and third vaccinations. Furthermore, we evaluated the impact of pretransplant vaccination for seropositivity. Of the 131 KT recipients, 50 had received the third dose of mRNA vaccine. The antibody titer was significantly increased after the third dose of mRNA vaccine. The seropositivity rate after the third dose of mRNA vaccine increased from 36 to 70%. We observed no significant difference in seropositivity after the third dose of mRNA vaccine in ABO incompatibility, rituximab use, mycophenolate mofetil use, and age at KT. Of the nine recipients who had received the second or third dose of the mRNA vaccine prior to the KT, eight of the recipients were seropositive both before and after the KT. Our results suggest that ABO incompatibility or rituximab use was not significantly associated with seropositivity.
Enhanced extraction of bioactive compounds from propolis (Apis mellifera L.) using subcritical water
Authors: Shin Su-Bin , Lee Jin-Kyoung , Ko Min-Jung 
Published: September 2023

AbstractThe bioactive compounds and antioxidant activities of propolis extracts were investigated using subcritical water extraction (SWE). SWE was performed by varying temperature (110–200 °C) and time (10–30 min). SWE using only water as solvent successfully to extracted bioactive compounds from propolis using high-purity glass thimbles. The concentrations of galangin (16.37 ± 0.61 mg/g), and chrysin (7.66 ± 0.64 mg/g) were maximal at 200 °C for 20 min, and 170 °C for 20 min, respectively. The antioxidative properties from propolis increased with the increasing extraction temperature and extraction time on SWE. The maximum yields of the total phenolics (226.37 ± 4.37 mg/g), flavonoids (70.28 ± 1.33 mg/g), and antioxidant activities (88.73 ± 0.58%, 98.86 ± 0.69%, and 858.89 ± 11.48 mg/g) were obtained at 200 °C for 20 min. Compared with using ethanol extraction (at 25 °C for 24 h, total phenolics = 176.28 ± 0.35, flavonoids = 56.41 ± 0.65, antioxidant activities = 72.74 ± 0.41%, 95.18 ± 0.11%, 619.51 ± 8.17 mg/g), all yields of SWE extracts obtained at 200 °C for 20 min were higher. SWE is suitable for a much faster and more efficient method extracting bioactive compounds from propolis compared to traditional extraction method.
Deciphering shared attributes of plant long non-coding RNAs through a comparative computational approach
Authors: Yadav Vikash Kumar , Jalmi Siddhi Kashinath , Tiwari Shalini , Kerkar Savita 
Published: September 2023

AbstractOver the past decade, long non-coding RNA (lncRNA), which lacks protein-coding potential, has emerged as an essential regulator of the genome. The present study examined 13,599 lncRNAs in Arabidopsis thaliana, 11,565 in Oryza sativa, and 32,397 in Zea mays for their characteristic features and explored the associated genomic and epigenomic features. We found lncRNAs were distributed throughout the chromosomes and the Helitron family of transposable elements (TEs) enriched, while the terminal inverted repeat depleted in lncRNA transcribing regions. Our analyses determined that lncRNA transcribing regions show rare or weak signals for most epigenetic marks except for H3K9me2 and cytosine methylation in all three plant species. LncRNAs showed preferential localization in the nucleus and cytoplasm; however, the distribution ratio in the cytoplasm and nucleus varies among the studied plant species. We identified several conserved endogenous target mimic sites in the lncRNAs among the studied plants. We found 233, 301, and 273 unique miRNAs, potentially targeting the lncRNAs of A. thaliana, O. sativa, and Z. mays, respectively. Our study has revealed that miRNAs, which interact with lncRNAs, target genes that are involved in a diverse array of biological and molecular processes. The miRNA-targeted lncRNAs displayed a strong affinity for several transcription factors, including ERF and BBR-BPC, mutually present in all three plants, advocating their conserved functions. Overall, the present study showed that plant lncRNAs exhibit conserved genomic and epigenomic characteristics and potentially govern the growth and development of plants.
Molecular characterization of MRSA collected during national surveillance between 2008 and 2019 in the Netherlands
Authors: Schouls Leo M. , Witteveen Sandra , van Santen-Verheuvel Marga , de Haan Angela , Landman Fabian , van der Heide Han , Kuijper Ed J. , Notermans Daan W. , Bosch Thijs , Hendrickx Antoni P. A. ,   the Dutch MRSA surveillance study group, van Arkel A. L. E. , Leversteijn-van Hall M. A. , van den Bijllaardt W. , van Mansfeld R. , van Dijk K. , Zwart B. , Diederen B. M. W. , Berkhout H. , Notermans D. W. , Ott A. , Waar K. , Ang W. , da Silva J. , Vlek A. L. M. , Buiting A. G. M. , Bode L. G. M. , Jansz A. , Paltansing S. , van Griethuysen A. J. , Ten Foe J. R. Lo , van Trijp M. J. C. A. , Wong M. , Muller A. E. , van der Linden M. P. M. , van Rijn M. , Debast S. B. , Kolwijck E. , Naiemi N. Al , Schulin T. , Dinant S. , van Mens S. P. , Melles D. C. , Stuart J. W. T. Cohen , Gruteke P. , van Dam A. , Maat I. , Maraha B. , Sinnige J. C. , van der Vorm E. , van Meer M. P. A. , van Maarseveen N. , de Jong E. , Vainio S. J. , Heikens E. , den Reijer M. , Dorigo-Zetsma J. W. , Troelstra A. , Bathoorn E. , de Vries J. , van Dam D. W. , de Brauwer E. I. G. B. , Steingrover R. 
Published: September 2023

Abstract
Background.
Although the Netherlands is a country with a low endemic level, methicillin-resistant Staphylococcus aureus (MRSA) poses a significant health care problem. Therefore, high coverage national MRSA surveillance has been in place since 1989. To monitor possible changes in the type-distribution and emergence of resistance and virulence, MRSA isolates are molecularly characterized.

Methods.
All 43,321 isolates from 36,520 persons, collected 2008–2019, were typed by multiple-locus variable number tandem repeats analysis (MLVA) with simultaneous PCR detection of the mecA, mecC and lukF-PV genes, indicative for PVL. Next-generation sequencing data of 4991 isolates from 4798 persons were used for whole genome multi-locus sequence typing (wgMLST) and identification of resistance and virulence genes.

Results.
We show temporal change in the molecular characteristics of the MRSA population with the proportion of PVL-positive isolates increasing from 15% in 2008–2010 to 25% in 2017–2019. In livestock-associated MRSA obtained from humans, PVL-positivity increases to 6% in 2017–2019 with isolates predominantly from regions with few pig farms. wgMLST reveals the presence of 35 genogroups with distinct resistance, virulence gene profiles and specimen origin. Typing shows prolonged persistent MRSA carriage with a mean carriage period of 407 days. There is a clear spatial and a weak temporal relationship between isolates that clustered in wgMLST, indicative for regional spread of MRSA strains.

Conclusions.
Using molecular characterization, this exceptionally large study shows genomic changes in the MRSA population at the national level. It reveals waxing and waning of types and genogroups and an increasing proportion of PVL-positive MRSA.
Continua of Support: A New Direction in the Identity-First/People-First Language Debate
Authors: Ogletree Billy T. 
Published: September 2023

Purpose:
This letter expresses the opinion that identity-first language and perspectives in care are essential. It argues that all individuals' support needs should be conceptualized along continua. One such continua is support for communication. It suggests that decisions to receive supports should be left to the individual and, when necessary, invested others who can share potential benefits and costs of support/no-support decisions. Dialogue on this important issue is recommended.
Fifty Shades of ChatGPT: Aktueller Diskussions- und Forschungsstand zu Sex und künstlicher Intelligenz
Authors: Döring Nicola 
Published: September 2023

ZusammenfassungGenerative künstliche Intelligenz (KI) ist ein Sammelbegriff für unterschiedliche Computeralgorithmen und -systeme, die mittels Maschinenlernen und Training auf sehr großen Datensätzen in der Lage sind, neue Inhalte wie Texte, Bilder und Musik zu kreieren. Diverse generative KI-Tools stehen der breiten Öffentlichkeit inzwischen zur Verfügung. Dabei ist ChatGPT als textgenerierende KI aktuell das bekannteste Werkzeug: Es weist rapide wachsende Nutzer*innenzahlen auf und hat seit seiner Veröffentlichung im November 2022 einen erneuten KI-Hype ausgelöst. KI-generierte Inhalte sind in vielfältiger Weise auch relevant für den Umgang mit Sexualität. Der vorliegende Beitrag stellt den aktuellen Diskussions- und Forschungsstand zu generativer KI und ihrer sexualbezogenen Nutzung dar. Dabei geht es um den Einsatz text- und bildgenerierender KI in drei zentralen Feldern: 1) Pornografie, 2) sexuelle Beziehungen und 3) Sexuelle Bildung. Chancen und Risiken sowie empirische Untersuchungsmöglichkeiten werden aufgezeigt.
Interpersonal Needs, Mental Pain, and Hopelessness in Psychiatric
Inpatients with Suicidal Ideation
Authors: Berardelli Isabella , Rogante Elena , Sarubbi Salvatore , Trocchia Maria Anna , Longhini Ludovica , Erbuto Denise , Innamorati Marco , Pompili Maurizio 
Published: September 2023

Abstract
Introduction Suicide is a leading cause of death worldwide and models may
help the understanding of the phenomenon and ultimately reduce its burden
through effective suicide prevention strategies. The Interpersonal Theory of
Suicide and Shneidman’s Model have tried to describe different unmet
needs related to suicidal ideation. The study aims to assess the association
between thwarted belongingness, perceived burdensomeness, and suicidal ideation
in a sample of psychiatric inpatients and the mediating role of hopelessness and
mental pain in this association.
Methods 112 consecutive adult psychiatric inpatients were administered the
Columbia Suicide Severity Rating Scale (C-SSRS), the Italian version of the
Interpersonal Needs Questionnaire-15-I (INQ-15-I), the Physical and
Psychological Pain Scale, and the Beck Hopelessness Scale (BHS).
Results Mediation models indicated a significant indirect effect of
perceived burdensomeness (with thwarted belongingness as covariates) on suicidal
ideation intensity with hopelessness as a mediator. When thwarted belongingness
(controlling for perceived burdensomeness as a covariate) was included in a
model as an independent variable, direct and indirect effects on suicidal
ideation intensity were not significant.
Conclusions Psychosocial interventions focusing on identifying and
decreasing the perception of being a burden for others and the feeling hopeless
could represent a powerful pathway for reducing suicidal ideation. Moreover, the
attention toward unmet interpersonal needs may help increase and focus clinical
discussions on risk factors, which may help engagement toward psychiatric care
and downsize the stigma related to suicide. Raising awareness toward mental
health topics is a goal of healthcare services globally.
Challenges and Management Strategies in the Nutrition of Older People with Diabetes
Authors: Farooqui Khalid , Khan Adeel Ahmad , Paul Theresa , Sirajudeen Jaseem , Khan Haseeb Ahmad , Farooqui Farah K. , Ferih Khalid RFA , Al-Yahary Hani Hassan , Haider Farrookh , Elzouki Abdel-Naser 
Published: September 2023

AbstractDiabetes has increased in prevalence and is the most common chronic metabolic disease worldwide. Its incidence and prevalence have particularly increased among older adults over the last few decades. The older adult population older than 60 years is diagnosed chiefly with type 2 diabetes, prediabetes, and type 1 diabetes in a small percentage; there is also an incidence of a transient form of diabetes secondary to chronic underlying diseases or as a part of their treatment-related complications. The primary goal in managing older adults with diabetes is to maintain glycemic status against the risk of hypoglycemia and its complications. In the older adult population, the problem of polypharmacy and nutrition must be kept in mind while achieving glycemic targets and preventing diabetes complications. Few studies have highlighted the importance of nutrition in older adults with diabetes and hypoglycemia as a complication leading to increased morbidity and mortality. Many factors in the older aged groups interplay in diabetes patients. Increasing the risk of hypoglycemia and managing nutritional aspects is paramount in older adults with diabetes mellitus. This review highlights various aspects of nutritional management in older adults with diabetes based on the current evidence available in the literature. However, most dietary recommendations for older adults with diabetes are based on studies in the adult population, and further studies targeting the older adult population are needed.
Global methane pledge versus carbon dioxide emission reduction
Authors: Cael B B , Goodwin P A 
Published: September 2023

Abstract
Methane (CH4) is a potent greenhouse gas whose contribution to anthropogenic radiative forcing of the climate system is second only to carbon dioxide (CO2). CH4 emission reduction has become critical to global climate mitigation policy, resulting most notably in the global methane pledge (GMP), pledging a 30% reduction of CH4 emissions by 2030. Methane is, however, much shorter-lived in the atmosphere than CO2, so emissions reductions may have different impacts on global warming over time. We quantify the difference over time in global annual mean surface temperature of the GMP versus the equivalent amount of CO2 emission reduction. The avoidance of CH4 emissions in the 2020s due to the GMP initially results in greater relative cooling than the avoidance of the equivalent amount of CO2 emissions over the same period, but less relative cooling after ∼2060, when almost all CH4 emitted during the 2020s has been removed from the atmosphere but much of the CO2 emitted during the 2020s remains. However, if the GMP places the world on a lower CH4 emissions trajectory after 2030, this results in a persistently and substantially greater reduction to global warming than the equivalent change in the CO2 emissions trajectory, with a maximum difference of 0.22 ± 0.06 ∘C in 2055 and relative cooling for well over a century. This equates to a large difference in avoided climate change damages if momentum in CH4 emission reduction from the GMP can be sustained after the 2020s. While the greatest reduction in warming is obtained by reducing both CH4 and CO2 emissions, our results underscore the striking global societal benefits of sustained reduction in CH4 emissions.
Bayesian phase difference estimation algorithm for direct calculation of fine structure splitting: accelerated simulation of relativistic and quantum many-body effects
Authors: Sugisaki Kenji , Prasannaa V S , Ohshima Satoshi , Katagiri Takahiro , Mochizuki Yuji , Sahoo B K , Das B P 
Published: September 2023

AbstractDespite rapid progress in the development of quantum algorithms in quantum computing as well as numerical simulation methods in classical computing for atomic and molecular applications, no systematic and comprehensive electronic structure study of atomic systems that covers almost all of the elements in the periodic table using a single quantum algorithm has been reported. In this work, we address this gap by implementing the recently-proposed quantum algorithm, the Bayesian phase difference estimation (BPDE) approach, to determine fine structure splittings of a wide range of boron-like atomic systems. Since accurate estimate of fine structure splittings strongly depend on the relativistic as well as quantum many-body effects, our study can test the potential of the BPDE approach to produce results close to the experimental values. Our numerical simulations reveal that the BPDE algorithm, in the Dirac–Coulomb–Breit framework, can predict fine structure splittings of ground states of the considered systems quite precisely. We performed our simulations of relativistic and electron correlation effects on Graphics Processing Unit by utilizing NVIDIA’s cuQuantum, and observe a ×42.7 speedup as compared to the Central Processing Unit-only simulations in an 18-qubit active space.
Denture use and risk for cardiometabolic disease: observational and Mendelian randomization analyses
Authors: Liu Yunan , Qin Haiqiang , Li Tongtong , Feng Chengwu , Han Han , Cao Yaying , Su Yang , He Haihao , Yuan Changzheng , Sun Meng , Clarke Robert , Gan Wei , Tonetti Maurizio , Zong Geng 
Published: September 2023

Abstract

Aims
Denture use may potentially increase the risk of cardiometabolic diseases (CMDs), but the casual relevance and strength of the associations are currently unknown.

Methods and results
A total of 495 938 participants from the UK Biobank were included in the observational analyses. Linkage disequilibrium score (LDSC) regression and Mendelian randomization analyses were employed to estimate genetic correlation and the associations between the genetic liability for denture use with coronary artery disease, myocardial infarction, heart failure (HF), any stroke (AS), ischaemic stroke, haemorrhagic stroke, type 2 diabetes (T2D), and related clinical risk factors. In observational analysis, denture use was associated with 14–25% higher risks of various CMDs. The LDSC analysis found that denture use showed a positive genetic correlation with CMDs (rg 0.21–0.38). Genetic liability for denture use was associated with an elevated risk of HF [odds ratio: 1.49 (1.20–1.83)] and T2D [1.11 (1.01–1.24)]. By integrating genetic summary data of denture use with the sum of decayed, missing, and filled tooth surfaces (DMFS), a clinical measure of dental caries obtained from an independent source, genetically determined denture use/DMFS was also associated with an elevated risk of AS [1.21 (1.04–1.40)]. Furthermore, genetically predicted denture use/DMFS was significantly associated with established cardiometabolic risk factors, including HDL cholesterol, triglycerides, waist circumference, waist-to-hip ratio, and height.

Conclusion
Our study supported potential causal associations between the genetic liability for denture use and risks for HF, AS, T2D, and related clinical risk factors. These findings may inform prevention and intervention strategies targeting dental diseases and CMDs.
Local Statistics of Random Permutations from Free Products
Authors: Puder Doron , Zimhoni Tomer 
Published: September 2023

Abstract
Let $\alpha $ and $\beta $ be uniformly random permutations of orders $2$ and $3$, respectively, in $S_{N}$, and consider, say, the permutation $\alpha \beta \alpha \beta ^{-1}$. How many fixed points does this random permutation have on average? The current paper studies questions of this kind and relates them to surprising topological and algebraic invariants of elements in free products of groups. Formally, let $\Gamma =G_{1}*\ldots *G_{k}$ be a free product of groups where each of $G_{1},\ldots ,G_{k}$ is either finite, finitely generated free, or an orientable hyperbolic surface group. For a fixed element $\gamma \in \Gamma $, a $\gamma $-random permutation in the symmetric group $S_{N}$ is the image of $\gamma $ through a uniformly random homomorphism $\Gamma \to S_{N}$. In this paper we study local statistics of $\gamma $-random permutations and their asymptotics as $N$ grows. We first consider $\mathbb{E}\big [\textrm{fix}_{\gamma }\big (N\big )\big ]$, the expected number of fixed points in a $\gamma $-random permutation in $S_{N}$. We show that unless $\gamma $ has finite order, the limit of $\mathbb{E}\big [\textrm{fix}_{\gamma }\big (N\big )\big ]$ as $N\to \infty $ is an integer, and is equal to the number of subgroups $H\le \Gamma $ containing $\gamma $ such that $H\cong \mathbb{Z}$ or $H\cong C_{2}*C_{2}$. Equivalently, this is the number of subgroups $H\le \Gamma $ containing $\gamma $ and having (rational) Euler characteristic zero. We also prove there is an asymptotic expansion for $\mathbb{E}\big [\textrm{fix}_{\gamma }\big (N\big )\big ]$ and determine the limit distribution of the number of fixed points as $N\to \infty $. These results are then generalized to all statistics of cycles of fixed lengths.
Fluoride Determination in Milk, Soy, and Water-Based Products Using Ion-Selective Electrode and Direct Measurement Technique: Single-Laboratory Validation, First Action 2022.05
Authors: Erney Renée M , Black Charles K 
Published: September 2023

Abstract

Background
The AOAC Stakeholder Panel on Infant Formula and Adult Nutritionals issued a call for methods for the determination of fluoride in infant formula. Standard Method Performance Requirement (SMPR®) 2014.016 was approved.

Objective
A single-laboratory validation (SLV) of a fluoride ion-selective electrode (F-ISE) method was completed.

Methods
Five powder samples were reconstituted, and hydrochloric acid was added to dissolve and release any bound fluoride. Samples included infant and adult nutritional products made from milk, whey, or soy, containing intact, partially hydrolyzed, or hydrolyzed proteins. Sodium citrate buffer was added to complex any interfering ions and adjust pH and ionic strength. Samples were analyzed in duplicate over 6 days using F-ISE.

Results
Results were calculated based on one of two least-squares (log fit) standard curves (0.02 to 0.1 µg/100 g or 0.1 to 2.0 µg/100 g). The LOQ for the method was determined to be 3.3 µg/100 g, which was far below the minimum analytical value of 30 µg/100 g required in the SMPR. The fluoride concentrations ranged from approximately 3 to 14 µg/100 g reconstituted powder and the intermediate precision, RSDr, ranged from 0.7 to 12.4%. Although all of these results are out of scope for the SMPR due to their low fluoride, it should be noted that the RSDr for formulas with fluoride concentrations ranging from approximately 9 to 14 µg/100 g ranged from 0.7 to 4.3%, and the RSDr for the two formulas with fluoride concentrations at or below the theoretical detection limit of the method were only approximately10 and 12.4%. Recoveries ranged from 94 to 98% for samples spiked at three levels with NIST-traceable standard solutions, meeting the SMPR.

Conclusion
The F-ISE method meets the SMPR and was adopted as a First Action Official MethodSM.

Highlights
The fluoride ion-selective electrode method presented here is affordable and easy to run. The addition of acid to the samples dissolves any minerals which may bind the fluoride.