bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hypoparathyroidism due to iron overload in beta-thalassemia patients
Authors: Razooqi Mohammed Mazin , Hazim Hamoode Rana , Ibrahim AL- Mahdawi Fatimah Kadhim 
Published: December 2022

Introduction and Aim: Beta-thalassemia is a genetic blood condition characterized by a lack of or abnormal globin chain synthesis, resulting in low hemoglobin levels needing repeated blood transfusions. Iron overload and skeletal issues are frequently observed in beta-thalassemia patients. The current study aims to assess the bone status of beta-thalassemia major patients who are on treatment with repeated blood transfusion and compare it to thalassemia patients who do not require blood transfusion.

Material and Methods: In this case-control study, conducted between December 2021 and April 2022 at Al-Shams Medical Laboratory, Diayla Governorate, 150 subjects were included consisting of 100 thalassemia patients and 50 healthy individuals.

Results: This study revealed that in patients with minor and moderate thalassemia, the levels of red blood and white blood cells considerably increased. Additionally, both minor and major thalassemia patients had significantly higher platelet counts, and a considerably higher iron and ferritin levels. PTH, vitamin D, calcium, and calcium phosphate levels all significantly decreased in major thalassemia patients when compared to patients with moderate thalassemia and the control group, however phosphorus levels sharply increased.

Conclusion: Patients with significant thalassemia have an unstable bone profile and hence, regular bone profile monitoring is recommended. In addition, such individuals are also advised to take calcium and vitamin D supplements and receive strong nutritional support.
Crystal structure, in silico molecular docking, DFT analysis and ADMET studies of N-(2-methoxy-benzyl)-acetamide
Authors: Murugan Suganya , Gunasekaran Prasanth , Nehru Jayasudha , Paul Anaglit Catherine , Dege Necmi , Cinar Emine Berrin , Kavitha Savaridasson Jose , Balasubramani Kasthuri , Thanigaimani Kaliyaperumal , Rajakannan Venkatachalam , Hemamalini Madhukar 
Published: December 2022

In this work, N-(2-methoxy-benzyl)-acetamide (2MBA) was synthesized from an amide derivative and it was characterized by FT-IR and NMR spectroscopy techniques. The crystal structure of 2MBA was also validated via single-crystal X-ray diffraction analysis. Crystal data for C10H13NO2 for 2MBA: Monoclinic, space group P21/n (no. 14), a = 9.1264(6) Å, b = 9.3375(7) Å, c = 11.9385(8) Å, β = 95.745(5)°, V = 1012.26(12) Å3, Z = 4, μ(MoKα) = 0.082 mm-1, Dcalc = 1.176 g/cm3, 5632 reflections measured (5.368° ≤ 2Θ ≤ 51.992°), 1990 unique (Rint = 0.0377, Rsigma = 0.0314) which were used in all calculations. The final R1 was 0.0583 (I > 2σ(I)) and wR2 was 0.1444 (all data). The intermolecular interactions in 2MBA were theoretically examined by Hirshfeld surface analysis and 2D fingerprint plots. Moreover, the HOMO and LUMO energy gaps of 2MBA was calculated by DFT calculation with the B3LYP/6-311G++(d,p) method. The electron-withdrawing and donating sites of the 2MBA were confirmed via molecular electrostatic potential surface analysis. The present study discusses the title compound not only highlighted the crystallographic data but also revealed good molecular interactions together with an anticancer drug target, which is a targeting PARP protein, which was an important drug target in the treatment of breast cancer.
TRANSTORNO DE OPOSIÇÃO DESAFIANTE (TOD): INTERVENÇÃO COGNITIVO-COMPORTAMENTAL
Authors: Viana Lidiane Rodrigues , Martins Maria das Graças Teles 
Published: December 2022

INTRODUÇÃO: O Transtorno de Oposição Desafiante (TOD) afeta crianças ou adolescentes. Apresenta características como desobediência, irritabilidade, raiva, comportamentos desafiadores, contestadores e negativistas para com figuras de autoridade. Fatores biológicos, temperamentais, aprendidos e condições psicológicas contribuem para padrões instáveis do TOD. OBJETIVO: Compreender as consequências provocadas pelo Transtorno de Oposição Desafiante (TOD) na criança e a atuação da terapia cognitivo comportamental no contexto da intervenção. METODOLOGIA: A metodologia utilizada foi a pesquisa bibliográfica e exploratória. Os materiais foram livros, teses, dissertações, monografias e artigos científicos disponíveis em bases de dados da Scielo, Pepsic, BvSaude, Periódicos eletrônicos. RESULTADOS: Evidenciou-se que as características das crianças com TOD envolvem temperamento impulsivo, desafiador e intolerância a frustrações e inabilidade no manejo social. Pode estar presente, perda frequente de paciência, alta irritabilidade, comportamento agressivo, impulsividade, ansiedade, teimosia constante, impaciência, hostilidade, forte descontrole emocional. A TCC se apresenta eficiente nas intervenções em crianças com o TOD. CONSIDERAÇÕES FINAIS: A intervenção da terapia cognitivo-comportamental (TCC) no tratamento do TOD se apresenta efetiva e envolve técnicas e estratégias direcionadas ao paciente tanto no ambiente clínico terapêutico, como no seu ambiente domiciliar, envolvendo os pais e outros sujeitos de seu convívio. Na intervenção da TCC o estabelecimento do vínculo, avaliação e formulação cuidadosa do caso, postura empática e assertiva, escuta atenta e respeitosa, sistema colaborativo entre paciente e terapeuta são importantes.
Bases metodológicas e informacionales para la elaboración de un manual de liderazgo infantil en la ciudad de La Paz, Bolivia
Authors: Aguilar Gutiérrez Diana Luz , Cordero Pozo Sergio Raul , Aguilera Santos Yelka 
Published: December 2022

La presente investigación tiene como objetivo profundizar en el conocimiento de las bases metodológicas e informacionales para la elaboración de un manual de liderazgo infantil en la educomunicación. La edad de los menores que forman parte de la presente investigación fue elegida entre siete a once años bajo el criterio de la tercera infancia, establecida por el psicólogo y filósofo suizo Jean Piaget, quién demuestra que en ese periodo las personas empiezan a usar su pensamiento lógico en situaciones concretas, realizan estrategias, reconocen sus limitaciones y muestran interés hacia actividades. La educación infantil debe reinventarse a las nuevas necesidades y problemáticas de una sociedad. Hoy más que nunca, es importante contar con líderes positivos en ámbitos políticos, empresariales, deportivos, económicos y culturales.
En la metodología se utilizó el enfoque de investigación mixto, el estudio explicativo, diseño no experimental transversal, método inductivo, técnicas como la entrevista, prueba de conocimiento y grupo focal. Asimismo, se utilizó la muestra no probabilística por conveniencia y se identificó a cuatro docentes del nivel primario, una psicopedagoga y una experta en liderazgo infantil para la recolección de datos.
Los datos recopilados permitieron describir la información y metodologías de trabajo para elaborar un manual de liderazgo, así como comprender el contexto educativo y social de los alumnos, medir el grado de conocimiento de los profesores respecto al liderazgo infantil y definir aspectos de contenido y estructura.
Entre los principales resultados se puede mencionar que los profesores consideran que la información y metodologías de trabajo del manual deben transmitir conceptos claves e instrucciones precisas que generen la inclusión de los menores, considerando sus valores, espíritu y moral, reforzando su autoestima y compañerismo.
En conclusión, los profesores consideran que es necesario promover el liderazgo a los niños, para que puedan tener ideas positivas y proyectarlas desde una temprana edad y así beneficiarse en todos los ámbitos cuando sean adultos. Asimismo, resaltan la importancia de los padres de familia, autoridades, personal de servicio e iglesia para incentivar esa aptitud en las Unidades Educativas.
Desenvolvimento Sustentável Rural na Baía da Babitonga: Projeto Multidisciplinar do Programa de Pós-Graduação em Tecnologia e Ambiente (PPGTA)
Authors: Rhoden Sandro , Ribeiro Eduardo , Neuenlfedt Patrícia , Somensi Cleder , Faria Daniel , Alves Leandro 
Published: December 2022

Contexto: Neste presente artigo apresentamos os contextos e as concepções teóricas que fundamentaram o projeto de pesquisa multidisciplinar do Mestrado Profissional em Tecnologia e Ambiente (PPGTA) aplicada em uma propriedade rural na baía da Babitonga. Metodologia: A propsosta metodológica deste trabalho é a convergência multidisciplinar de conhecimentos distintos, possibilitando a reflexão de diferentes perspectivas para a solução dos problemas intrínsecos da relação sociedade-natureza em determinado território. Dessa maneira, esta práxis científica passa a ser identificada como atitude e como método na produção de conhecimento desta área de avaliação. Resultados: A proposta desta convergência multidisciplinar de conhecimentos no Programa de Pós-Graduação em Tecnologia e Ambiente (PPGTA) está contemplada na área de concentração do curso que é o Desenvolvimento de Processos e Tecnologias Ambientais.
Pengaruh Profitabilitas dan Ukuran Perusahaan Terhadap Nilai Perusahaan Pada Perusahaan Farmasi Yang Terdaftar di Bursa Efek Indonesia Periode 2016-2020
Authors: Keni Christine Elisabeth , Pangkey Royke 
Published: December 2022

Penelitian ini menguji pengaruh profitabilitas dan ukuran perusahaan terhadap nilai perusahaan farmasi yang terdaftar di Bursa Efek Indonesia Tahun 2016-2020. Penelitian ini menggunakan metode kuantitatif dan data sekunder. Metode pengambilan sampel menggunakan purposive sampling dan diperoleh 9 perusahaan selama 5 tahun. Teknik analisis yang digunakan adalah regresi data panel dengan menggunakan aplikasi pengolahan data Eviews 10 untuk memperoleh gambaran secara menyeluruh terkait hubungan antara variabel satu dengan variabel lainnya. Hasil penelitian menunjukkan bahwa profitabilitas berpengaruh positif signifikan terhadap nilai perusahaan dan ukuran perusahaan berpengaruh positif signifikan terhadap nilai perusahaan.
Optimal Integration of Electric Vehicle Charging Stations and Compensating Photovoltaic Systems in a Distribution Network Segregated into Communities
Authors: Tounsi Fokui Willy Stephen , Ngoo Livingstone , Saulo Michael 
Published: December 2022

This paper proposes a method of optimally utilizing electric vehicles (EVs) in the distribution network. The method is firstly based on segregating the distribution network into communities and then optimally placing an EV charging station (EVCS) in each community using the backward forward sweep (BFS) technique. The Second phase uses particle swarm optimization (PSO) to size and allocates photovoltaic systems in the network for power loss minimization and voltage improvement. The proposed method is tested on an IEEE 33 node test feeder and simulation results showed the effectiveness of the BFS in finding the best nodes for the placement of EVCS in each community as well as the effectiveness of the PSO in allocating the photovoltaic systems. To validate the effectiveness of the BFS technique, its results obtained are compared with those obtained when the EVCSs are placed on some nodes other than those chosen by the BFS technique.This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium provided the original work is properly cited.
Assessing Medical Student Fear and Shame as Barriers to Active Participation on the Wards
Authors: Barry Katherine , Schiffman Fred J. , Collins Bradley J. 
Published: December 2022

Purpose Imposter syndrome is common among medical trainees, who have been shown to experience self-doubt and burnout at alarming rates. Trainees also experience anxiety and fear about asking and answering questions on their clinical rotations, which may affect engagement and ability to learn. This study seeks to characterize fear and shame that fourth year medical students have felt during their time on clinical rotations, as well as the effect that this has had on their willingness to participate in clinical discussions. Method The authors sent a survey to all fourth-year medical students at a US medical school. Survey questions included assessment of experiencing fear and anxiety while being asked questions during ward rounds. Students completed the survey using a web link to 10 questions on a 5-point Likert scale. Results 58 students completed the questionnaire. Fifty one (87.9%) of the students responded they experienced stress or anxiety when an attending physician asked them questions at least sometimes. Forty five (77.6%) experienced fear when questioned on rounds. Fourty four (75.9%) did not answer questions for fear of being wrong and exposing lack of knowledge. Thirty five (60.3%) experienced shame when questioned on rounds. Over 50% reported they were afraid to answer questions in specialties they were interested in. Most cited specialties that caused fear were Internal Medicine, Emergency Medicine, Surgery, and Obstetrics and Gynecology. Conclusions Though attempts are being made to improve the clinical learning environment and reduce the effects of imposter syndrome and anxiety in medical education, fear still plays a role in medical students’ minds when choosing to ask or answer questions on the wards. Larger studies are needed to further look at the prevalence of this phenomenon and efforts should continue to be made to mitigate fear on the wards.
Preparation and Quality Evaluation of Functional Persimmon (Diospyros kaki) Juice for Diabetic Patients.
Authors: Mukhtiar Ahmad Mukhtiar Ahmad 
Published: December 2022

Abstract
Persimmon (Diospyros kaki) a delicious fruit belongs to Rahmanaceae family. It is a climacteric fruit which is successfully grown in all regions of the world. Persimmon a perishable fruit which is consumed in both fresh and processed forms. It is a rich source of essential nutrients and bioactive compounds such as protein, vitamins, minerals, tannin, flavonoids and carotenoids. The current study was planned to investigate the antidiabetic potential of low calorie persimmon juice under different intervals of time. For this objective persimmon pulp was separated from peel and then it was analyzed for quality parameters. After chemical analysis persimmon pulp revealed that crude protein, crude fat, crude fiber, total phenolic, microbiological contents, calcium, and magnesium were 0.56±0.05%, 0.16±0.02%, 3.85±0.05, 12.41±0.39GAE/g, 4.60±0.26log10 CFU/g, 7.5±0.02mg, 156.5±0.11mg and 8.83±0.03mg, respectively. Persimmon juice was prepared by adding various levels of persimmon pulp. The results showed that the persimmon juice contained a lot of antidiabetic activity. It is concluded that low calorie persimmon juice would be appropriate choice for diabetic patients.
Keywords: Persimmon fruit composition; bioactive compounds; persimmon juice; antidiabetic potential.
PENERAPAN MODEL PEMBELAJARAN PROBLEM BASED LEARNING UNTUK MENINGKATKAN HASIL BELAJAR SISWA PADA MUATAN PELAJARAN ILMU PENGETAHUAN SOSIAL MATERI JENIS-JENIS USAHA MASYARAKAT INDONESIA KELAS V SDS EKA TJIPTA KENCANA
Authors: Fajar Septyawan  
Published: December 2022

Learning and teaching are essentially a reciprocal relationship between teachers and learners. The use of media and learning methods chosen by teachers is one way to improve the quality of learning. Problem Based Learning is an innovation in learning because in PBL students' thinking skills are really optimized through a systematic group or team work process, so that students can empower, hone, test and develop their thinking skills on an ongoing basis. This study used Classroom Action Research. Data is obtained through data collection in the field which is carried out using observation techniques, learning outcome test techniques, and documentation. From the results of the analysis, the results were obtained that after the implementation of the Problem Based Learning learning model, there was an increase in teacher activity, an increase in student activity and an increase in student learning outcomes. From the results of the research conducted, it is suggested that SDS Eka Tjipta Kencana teachers can use the Problem Based Learning learning model as an alternative learning to improve student learning outcomes
A Case of ‘Multi-Inflammatory Syndrome in Children’ Complicated with Cardiogenic Shock
Authors: Biçer Nazmiye Serap , Türe Zeynep , Ülger Birkan , Esmaoğlu Aliye 
Published: December 2022

SARS Cov-2 infection causes Multi-Inflammatory Syndrome in Children (MIS-C), a serious condition that affects children. We report an 18-year-old Turkish male who was diagnosed with MIS-C and successfully treated. He was diagnosed with MIS-C and required invasive mechanical ventilation due to cardiogenic shock, after what he recovered. With a high temperature, rash, and conjunctival hyperemia, the patient was taken to the emergency department. He had no symptomatic COVID-19 in his medical history, although he had had contact with a COVID-19 positive patient in the near past. Physical examination revealed an erythematous maculopapular rash on the back and neck, as well as hepatosplenomegaly. SARS-CoV-2 IgM and IgG positivity were detected in the rapid antibody test. Following the procedure, rectal bleeding and tachypnea developed. Inflammation indicators and pro-BNP levels both increased. With echocardiogenic examination, the ejection fraction decreased from 50-55 percent to 35%. He needed invasive mechanical ventilation. As a result, the case was classified as MIS-C with predominant cardiac and gastrointestinal involvement. The patient was discharged after a successful multidisciplinary approach. Although COVID-19 infection in children and adolescents is asymptomatic or minimally symptomatic, clinicians should be aware of post-infection autoimmune complications.
Ceremonial, honores y honras fúnebres por el fallecimiento de María de las Mercedes de Orleans y Borbón (II).
Authors: Mesa Göbel José Manuel 
Published: December 2022

El fallecimiento de María de las Mercedes de Orleans, hecho de indudable relevancia dentro del reinado de Alfonso XII y de evidentes connotaciones dinásticas, políticas e incluso diplomáticas en la reciente restaurada monarquía, va a traer como resultado el desarrollo de una serie de actos que trasciende el ámbito territorial de la península Ibérica, con la celebración de distintas honras fúnebres y exequias en Filipinas, Cuba y Puerto Rico, y otros países donde con carácter oficial llevarán a cabo dichos actos, y el desarrollo de similares exequias en otros países, asumidas por los españoles residentes en estos o en su caso por las representaciones diplomáticas y oficiales, como ocurre en México, Italia y Francia. Por tanto, supone poner en marcha ya sea con carácter oficial o privado determinados actos para tributar las honras fúnebres y los honores a la memoria de la reina fallecida. En unos casos y tal como podremos ver en el desarrollo del artículo con una normativa específica del territorio en la que se lleva a cabo y con distintos actos secundarios propios de lo que las ordenanzas establecían al respecto para otras ocasiones similares y en otros, por la propia organización de distintas instituciones españolas en un país determinado. Por tanto, desde el punto de vista del ceremonial, el protocolo y los honores tributados una forma de llevar a cabo y coordinar las exequias, honras fúnebres y la tributación de honores desde una perspectiva particular y propia. Destacando la posibilidad de poder contar con fuentes de investigación que nos dan dicha visión con carácter general.
Learning in the transformation of organizations with the implementation of agile methods
Authors: Rodrigues Eliane Lima , Scafuto Isabel Cristina 
Published: December 2022

Objective: This article aims to understand the influence of organizational learning on adaptation during the implementation of agile methods in the project management environment in companies. The study focuses on changing project management processes from the traditional “waterfall” to agile management models to meet the needs of organizations. It aims to identify how the organization based on traditional project management migrates to a new process, adapting the new agile methodology to its day-to-day activities. Design/methodology/approach: We carried out a systematic literature review, answering the question: How does organizational learning influence the adaptation of agile methods? Results: We grouped the articles into five fields of research: Agile Learning; Organizational Learning in the implementation of Lean and Scrum methodologies: Implementation of Lean and Scrum methodologies; Learning of the individual in the organization and Organizational Learning. Originality/Value: This article seeks interests in the potential of applying agile projects and the organizational learning acquired from this new model.
Ionic Covalent Organic Frameworks‐Derived Cobalt Single Atoms and Nanoparticles for Efficient Oxygen Electrocatalysis
Authors: Guo Jiaming , Li Wenqiong , Xu Yuncun , Mao Yanqi , Mei Zhiwei , Li Haihan , He Yun , San Xingyuan , Xu Kui , Liang Xiaoguang 
Published: December 2022

AbstractMetal single atoms show outstanding electrocatalytic activity owing to the abundant atomic reactive sites and superior stability. However, the preparation of single atoms suffers from inexorable metal aggregation which is harmful to electrocatalytic activity. Here, ionic covalent organic frameworks (iCOFs) are employed as the sacrificial precursor to mitigate the metal aggregation and subsequent formation of bulky particles. Molecular dynamics simulation shows that iCOFs can trap and confine more Co ions as compared to neutral COFs, resulting in the formation of a catalyst composed of Co single atoms and uniformly distributed Co nanoparticles (CoSA&CoNP‐10). However, the neutral COFs derive a catalyst composed of Co atomic clusters and large Co nanoparticles (CoAC&CoNP‐25). The CoSA&CoNP‐10catalyst exhibits higher oxygen bifunctional electrocatalytic activities than CoAC&CoNP‐25, coinciding with the density functional theory results. Taking the CoSA&CoNP‐10as the air cathode in Zn–air batteries (ZABs), the aqueous ZAB presents a high power density of 181 mW cm−2, a specific capacity of 811 mAh g−1as well as a long cycle life of 407 h at a current density of 10 mA cm−2, while the quasi‐solid state ZAB displays a power density of 179 mW cm−2and the cycle life of 30 h.
3D Interconnected Honeycomb-Like Multifunctional Catalyst for Zn–Air Batteries
Authors: Jin Tianxu , Nie Junli , Dong Mei , Chen Binling , Nie Jun , Ma Guiping 
Published: December 2022

AbstractDeveloping high-performance and low-cost electrocatalysts is key to achieve the clean-energy target. Herein, a dual regulation method is proposed to prepare a 3D honeycomb-like carbon-based catalyst with stable Fe/Co co-dopants. Fe atoms are highly dispersed and fixed to the polymer microsphere, followed by a high-temperature decomposition, for the generation of carbon-based catalyst with a honeycomb-like structure. The as-prepared catalyst contains a large number of Fe/Co nanoparticles (Fe/Co NPs), providing the excellent catalytic activity and durability in oxygen reduction reaction, oxygen evolution reaction and hydrogen evolution reaction. The Zn-air battery assembled by the as-prepared catalyst as air cathode shows a good charge and discharge capacity, and it exhibits an ultra-long service life by maintaining a stable charge and discharge platform for a 311-h cycle. Further X-ray absorption fine structure characterization and density functional theory calculation confirms that the Fe doping optimizes the intermediate adsorption process and electron transfer of Co.