bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enhancing the wind farm‐based power system stability with coordinated tuned supplementary controller
Authors: Bhukya Jawaharlal 
Published: July 2023

SummaryThe effects of the wind farm on the low‐frequency oscillations of interconnected power systems have become a significant problem with extensive apprehension. These low‐frequency oscillations are undesirable, malfunctioning and resulting in system instability. This paper studies the influence of various factors on stability, with varying wind penetration, a different combination of controllers, wind farm (WF) integration and replacement of synchronous generators. To enhance the stability, it is integrated and analyzed significance of the controller by considering the power oscillation damper for WF, power system stabilizer for synchronous generators and supplementary controller of flexible AC transmission system devices for the system. The rotor speed deviation is considered an objective function with various constraints for particle swarm optimization to provide the controller's optimized value and combination. The small‐signal and transient stability problems were examined using eigenvalue analysis and time‐domain simulation. The state‐space formulation is derived for eigenvalue analysis for small signal stability assessment with system variables. The nonlinear dynamic simulation results for transient stability analysis are obtained using a three‐phase fault. From stability analysis, coordinated controllers intensify the capability of SGs and WF under extreme disturbances. The effectiveness and robustness of the proposed approaches have been verified using the IEEE‐9 bus test system. All the analysis and simulations are performed using real time digital simulation (RTDS) with interfacing between MATLAB/SIMULINK‐2018a software and RT‐LAB (an OP5600 RT‐LAB).
Competition between pink muhly grass and native plant species: Is it really a harmful invasive species?
Authors: Byun Chaeho 
Published: July 2023

AbstractPink muhly grass (Muhlenbergia capillaris Trin.) is an exotic species in South Korea and is popular worldwide as an ornamental grass for landscaping purposes. The Ministry of Environment in South Korea has categorized this species as an “Ecosystem Hazard Class 2” plant, requiring long‐term monitoring to assess its ecological impacts on native species and communities. In this study, a 2‐year greenhouse experiment was conducted using M. capillaris and 17 native plant species (6 annuals, 8 nonwoody perennials, and 3 woody perennials) to test the hypothesis that if M. capillaris is an invasive species, it will negatively affect the establishment and growth of native plants in competitive pairings compared with controls (native species grown in monoculture). Results showed that the mean canopy cover of native plants in competition with M. capillaris was not significantly different from monocultures of the corresponding native species. There were also no significant differences in mean aboveground biomass production between native species growing with M. capillaris compared to corresponding native monocultures. Results indicate that M. capillaris did not significantly affect the establishment and growth of the 17 native species investigated. The minimal impacts suggest that M. capillaris may not be a harmful invasive species, but further monitoring of its spread will be required to test these findings under natural conditions.
Chemoenzymatic Synthesis of Enantiopure Amino Alcohols from Simple Methyl Ketones
Authors: Neuburger Jan Eric , Gazizova Alina , Tiedemann Sven , von Langermann Jan 
Published: July 2023

AbstractThis study highlights the straight‐forward synthesis of substituted 1,2‐amino alcohols from simple and readily available aromatic methyl ketones. Starting from acetophenone derivatives, the straight‐forward synthesis strategy involved an initial bromination of the alpha‐positioned methyl group in the first step, followed by a simple hydrolysis to the hydroxyketone (2‐hydroxyacetophenone). The hydroxylated intermediate was subsequently converted from Silicibacter pomeroyi to the final 1,2‐amino alcohol by using the transaminase. The transaminase‐catalyzed reaction proceeded with yields up to 62 % and always excellent enantiomeric excess of >99 %. Interestingly, the keto‐enol‐tautomerism of the hydroxyl ketone yields an unexpected amino alcohol isomer.
Statistical optimization of ultrasound‐assisted biodiesel production from Moringa oleifera oil – waste cooking oil mixture using modified conch shell catalyst
Authors: Niju Subramaniapillai , Aishwarya Kesav , Balajii Muthusamy , Asaithambi Perumal 
Published: July 2023

AbstractBiodiesel is a potential alternative fuel that offers several environmental benefits and can be used in conventional engines. However, high feedstock cost poses a challenge for its commercial viability. This study focuses on producing biodiesel using waste cooking oil (WCO) and Moringa oleifera oil (MOO) as feedstock, with a specific emphasis on the use of modified conch shell as solid catalyst under ultrasonic conditions. Different mixtures of WCO and MOO were evaluated for their suitability in a two‐stage esterification transesterification process, and the acid value of the WCO‐MOO blend was reduced through an ultrasound‐assisted esterification process. Additionally, a calcium oxide‐based catalyst was developed from conch shells (CS) through calcination for 3 h at 900°C and further modified using water and methanol. The characterization studies confirm the successful development and modification of the CS catalyst and also demonstrates excellent catalytic activity. The ultrasound assisted transesterification process parameters were optimized using response surface methodology (RSM) based Box–Behnken design (BBD). By employing a catalyst loading of 5.8 wt%, methanol to esterified oil volumetric ratio of 0.37:1, and an ultrasonication time of 57 min, a maximum predicted methyl ester conversion of 94.7% was achieved. Therefore, this work provides valuable insights into the use of modified conch shell catalyst for biodiesel production from WCO and MOO mixtures thereby contributing to the advancement of cost‐effective and environmentally friendly biodiesel production methods.
Affordable Care Act Medicaid expansions and maternal morbidity
Authors: Chatterji Pinka , Glenn Hanna , Markowitz Sara , Montez Jennifer Karas 
Published: July 2023

AbstractIn this paper, we test whether the Affordable Care Act Medicaid expansions are associated with maternal morbidity. The ACA expansions may have affected maternal morbidity by increasing pre‐conception access to health care, and by improving the quality of delivery care, through enhancing hospitals' financial positions. We use difference‐in‐difference models in conjunction with event studies. Data come from individual‐level birth certificates and state‐level hospital discharge data. The results show little evidence that the expansions are associated with overall maternal morbidity or indicators of specific adverse events including eclampsia, ruptured uterus, and unplanned hysterectomy. The results are consistent with prior research showing that the ACA Medicaid expansions are not statistically associated with pre‐pregnancy health or maternal health during pregnancy. Our results add to this story and find little evidence of improvements in maternal health upon delivery.
The urgent need for a policy on epidemiological data on cardiovascular diseases in Bangladesh
Authors: Proma Amrin Yeasin , Das Proma Rani , Akter Sayma , Dewan Syed Masudur Rahman , Islam Mohammad Safiqul 
Published: July 2023

AbstractBackgroundDisease prevention and healthcare policy choices cannot be made without epidemiology data. Since it is a growing country with rapidly increasing illness rates, this information is in great demand in Bangladesh. This is because there is a shortage of reliable and sufficient data, leading to inadequate preventive and treatment methods.DiscussionPoor health concerns and economic conditions mean that not all families can afford to provide the nutrition their members need, leading to an increase in the prevalence of many diseases. The outcome is an ever‐increasing threat of cardiovascular disease (CVD) issues, the leading cause of death in Bangladesh, even though the underlying causes remain unknown. There is a strong demand for accurate information on CVD patients in Bangladesh, however, there is no effective framework for managing epidemiological data. This prevents an in‐depth analysis of the nation's socioeconomic status, dietary practices, and way of life, as well as the implementation of sound healthcare policy.ConclusionIn this article, we present arguments on this important issue using the healthcare systems of the developed world and Bangladesh as examples.
Thermally radiative slip flow of viscous fluid through a microfluidic vessel having sinusoidal walls with variable viscosity
Authors: Abbas Z. , Rafiq M. Y. , Ahsan S. , Khaliq S. 
Published: July 2023

AbstractThis article explores the influence of variable viscosity on the peristaltic movement of viscous fluid through a tapered microfluidic vessel having sinusoidal walls. The aspect of slip velocity has been considered on the channel walls. Furthermore, the heat transfer phenomenon is explored under the effectiveness of thermal radiation and viscous dissipation. The nonlinearity of the problem is scrutinized by the lubrication approximation hypothesis. Analytic outcomes have been acquired for liquid velocity, temperature, pressure rise, and streamlines. The impact of dissimilar physical parameters influencing the liquid flow features is revealed and deliberated through graphs. The study revealed that the velocity at the central region diminishes with increasing values of the velocity slip parameter. The number of boluses in the streamlines pattern is enhanced by enhancing the viscosity parameter. The current model has been used in bio‐engineering processes, industrial fluid mechanics, thermal processing, and cooling systems.
An exploration of ventricle regions segmentation and multiclass disease detection using cardiacMRI
Authors: Subha V. , Gomathi G. , Manivanna Boopathi A. 
Published: July 2023

AbstractIn this modern era, various cardiac diseases are very crucial as they cause a high mortality rate. Early detection of cardio vascular disease (CVD) is essential to prevent and control it. Diagnosis of cardiac disease is the process of analyzing the left and right ventricle cavities (LV, RV) and myocardium (MYO) from cardiac magnetic resonance (CMR) images. As deep learning architectures are becoming more mature, segmenting, and classifying cardiac MRI images using deep learning is gaining more attention. This work is aimed to identify five different cardiac disease subgroups namely NOR, MINF, DCM, HCM, and ARC by employing a new deep join attention model (DJAM) technique for segmenting LV, MYO, and RV regions separately. This method provides advancement as the joined attention model was combined with the pooling layers and the resultant is added to the convolution layers. The proposed region integrated deep residual network (RIDRN) is used to extract the features from the segmented images for classification. In this process, the features of LV, RV, and MYO are combined with a different combination. The advantage of doing this process is to get the overall features without leaving any single strip of features from the three regions. Hence, it shows a rise in performance accuracy. The random forest classification method is used to classify the underlying features for cardiac disease diagnosis. This proposed work is tested in the automated cardiac diagnosis challenge (ACDC) dataset and it perfects the state‐of‐art techniques.
Evaluating the impact of emergency department clinical pharmacist integration within a discharge urine culture follow‐up program
Authors: Zhao Yang , Stornelli Nicholas , McAllister Kelly , McDaniel Lauren , Schad Jessica 
Published: July 2023

AbstractIntroductionPatients are often discharged from the emergency department (ED) prior to final culture results, leading to the development of post‐ED discharge urine culture review programs (UCRPs) to ensure appropriate management. The purpose of this study was to evaluate the impact ED pharmacists have on antibiotic management and determine areas for improved antimicrobial stewardship efforts.MethodsThis was a single‐system, retrospective, quasi‐experimental study of patients who visited the ED for evaluation of a urinary tract infection comparing no pharmacist involvement in a culture review to a process when ED pharmacists were involved. Patients included those discharged from the ED requiring review under a UCRP. Incarcerated patients and those admitted to an inpatient service from the ED were excluded. The primary outcome was the receipt of guideline‐appropriate management. Secondary outcomes included unplanned admission or ED revisit within 14 and 30 days related to the initial ED visit, all‐cause hospital admission or ED revisit within 14 and 30 days, and acceptance rate of pharmacist recommendations.ResultsA total of 142 patients were included (before pharmacist integration = 70, after pharmacist integration = 72). Receipt of guideline‐appropriate management occurred at 33% without pharmacist integration and 85% in the arm with pharmacist integration, p < 0.001. Pharmacist recommendations were accepted in 97% of cases. No difference was noted between ED revisit within 14 and 30 days with a chief complaint directly related to the initial ED visit, 14 and 30 day admission related to the initial encounter, and all‐cause hospital admission or ED revisit within 14 and 30 days. In patients with asymptomatic bacteriuria, there was a higher receipt of inappropriate management 67% (20/30) in the time before pharmacist integration versus 19% (9/48) after pharmacist integration (p < 0.001).ConclusionThere was a significantly higher number of patients with appropriate antimicrobial management after pharmacist involvement in UCRP review.
UVB promotes melanogenesis by regulating METTL3
Authors: Guo Haoran , Zeng Hongliang , Hu Yibo , Jiang Ling , Lei Li , Hung Jinhua , Fu Chuhan , Li Hui , Long Yan , Chen Jing , Zeng Qinghai 
Published: July 2023

AbstractUltraviolet (UV) radiation is the primary exogenous inducer of skin pigmentation, although the mechanism has not been fully elucidated. N6‐methyladenosine (m6A) modification is one of the key epigenetic form of gene regulation that affects multiple biological processes. The aim of this study was to explore the role and underlying mechanisms of m6A modification in UVB‐induced melanogenesis. Low‐dose UVB increased global m6A modification in melanocytes (MCs) and MNT1 melanoma cell line. The GEPIA database predicted that methyltransferase METTL3 is positively correlated with the melanogenic transcription factor MITF in the sun‐exposed skin tissues. After METTL3 respectively overexpressed and knocked down in the MNT1, the melanin content and melanogenesis‐related genes were significantly upregulated after overexpression of METTL3, especially with UVB irradiation, and downregulated after METTL3 knockdown. METTL3 levels were also higher in melanocytic nevi with high melanin content. METTL3 overexpression and knockdown also altered the protein level of YAP1. SRAMP analysis predicted four high‐potential m6A modification sites on YAP1 mRNA, of which three were confirmed by methylated RNA immunoprecipitation. Inhibition of YAP1 expression can partially reverse melanogenesis induced by overexpression of METTL3. In conclusion, UVB irradiation promotes global m6A modification in MCs and upregulates METTL3, which increases the expression level of YAP1 through m6A modification, thereby activating the co‐transcription factor TEAD1 and promoting melanogenesis.
Molecular modeling and rational design of disulfide‐stapled self‐inhibitory peptides to target IL‐17A/IL‐17RA interaction
Authors: Huang Weihua , Zhou Yang , Pan Chunhua , Zhang Xin , Zhao Huijun , Shen Lili 
Published: July 2023

AbstractInterleukin‐17A (IL‐17A) is a pro‐inflammatory cytokine implicated in diverse autoimmune and inflammatory disorders such as psoriasis and Kawasaki disease. Mature IL‐17A is a homodimer that binds to the extracellular type‐III fibronectin D1:D2‐dual domain of its cognate IL‐17 receptor A (IL‐17RA). In this study, we systematically examined the structural basis, thermodynamics property, and dynamics behavior of IL‐17RA/IL‐17A interaction and computationally identified two continuous hotspot regions separately from different monomers of IL‐17A homodimer that contribute significantly to the interaction, namely I‐shaped and U‐shaped segments, thus rendered as a peptide‐mediated protein–protein interaction (PmPPI). Self‐inhibitory peptides (SIPs) are derived from the two segments to disrupt IL‐17RA/IL‐17A interaction by competitively rebinding to the IL‐17A‐binding pocket on IL‐17RA surface, which, however, only have a weak affinity and low specificity for IL‐17RA due to lack of the context support of intact IL‐17A protein, thus exhibiting a large flexibility and intrinsic disorder when splitting from the protein context and incurring a considerable entropy penalty when rebinding to IL‐17RA. The U‐shaped segment is further extended, mutated and stapled by a disulfide bridge across its two strands to obtain a number of double‐stranded cyclic SIPs, which are partially ordered and conformationally similar to their native status at IL‐17RA/IL‐17A complex interface. Experimental fluorescence polarization assays substantiate that the stapling can moderately or considerably improve the binding affinity of U‐shaped segment‐derived peptides by 2–5‐fold. In addition, computational structural modeling also reveals that the stapled peptides can bind in a similar mode with the native crystal conformation of U‐shaped segment in IL‐17RA pocket, where the disulfide bridge is out of the pocket for avoiding intervene of the peptide binding.
Evaluation of Inferior and Superior Vena Cava and the Vena Cava Ratio in Growth Restricted Fetuses
Authors: Uzun Çilingir Işıl , Sayın Cenk , Sutcu Havva , İnan Cihan , Erzincan Selen , Varol Füsun 
Published: July 2023

ObjectiveTo evaluate the changes in the diameters of superior vena cava (SVC) and inferior vena cava (IVC) and to measure the ratio between SVC and IVC in growth‐restricted fetuses and compare these results with normally grown fetuses.MethodsTwenty‐three consecutive patients with fetal growth restriction (FGR) (Group I) and 23 pregnant gestational age‐matched controls (Group II) between 24 and 37 weeks of gestation were enrolled in the study between January 2018 and October 2018. The diameter of the SVC and IVC from inner wall to inner wall was measured in all patients by sonographic examination. The ratio between the diameter of the SVC and IVC was also measured in each patient to eliminate the gestational age factor. We have named this ratio the “vena cava ratio” (VCR). All parameters were compared between the two groups.ResultsThe diameter of the SVC was significantly greater in the fetuses with FGR (2.6–7.7 [5.4]) than in controls (3.2–5.6 [4.1]; P = .002; P < .01). The diameter of the IVC was significantly less in the fetuses with FGR (1.6–4.5 [3.2]) than in controls (2.7–5 [3.7]; P = .035; P < .05). The VCR was between 1.1 and 2.3 and the median value was 1.8 in Group I. The VCR was between 0.8 and 1.7 and the median value was 1.2. VCR was significantly higher in fetuses with FGR (P = .001 P < .01).ConclusionThis study shows that VCR is higher in fetuses with growth restriction. Further studies are needed to clarify the association between VCR and antenatal prognosis and postnatal results.
Updated temperature correction for computing seawater nitrate with in situ ultraviolet spectrophotometer and submersible ultraviolet nitrate analyzer nitrate sensors
Authors: Plant Joshua N. , Sakamoto Carole M. , Johnson Kenneth S. , Maurer Tanya L. , Bif Mariana B. 
Published: July 2023

AbstractSensors that use ultraviolet (UV) light absorption to measure nitrate in seawater at in situ temperatures require a correction to the calibration coefficients if the calibration and sample temperatures are not identical. This is mostly due to the bromide molecule, which absorbs more UV light as temperature increases. The current correction applied to in situ ultraviolet spectrophotometer (ISUS) and submersible ultraviolet nitrate analyzer (SUNA) nitrate sensors generally follows Sakamoto et al. (2009, Limnol. Oceanogr. Methods 7, 132–143). For waters warmer than the calibration temperature, this correction model can lead to a 1–2 μmol kg−1 positive bias in nitrate concentration. Here we present an updated correction model, which reduces this small but noticeable bias by at least 50%. This improved model is based on additional laboratory data and describes the temperature correction as an exponential function of wavelength and temperature difference from the calibration temperature. It is a better fit to the experimental data than the current model and the improvement is validated using two populations of nitrate profiles from Biogeochemical Argo floats navigating through tropical waters. One population is from floats equipped with ISUS sensors while the other arises from floats with SUNA sensors on board. Although this model can be applied to both ISUS and SUNA nitrate sensors, it should not be used for OPUS UV nitrate sensors at this time. This new approach is similar to that used for OPUS sensors (Nehir et al., 2021, Front. Mar. Sci. 8, 663800) with differing model coefficients. This difference suggests that there is an instrumental component to the temperature correction or that there are slight differences in experimental methodologies.
A Minkowski difference‐based advancing front packing technique for generating convex noncircular particles in complex domains
Authors: Xia Ming , Xu Xin , Gong Fengqiang , Wang Min , Feng Y. T. 
Published: July 2023

AbstractIn this work, a Minkowski difference‐based advancing front approach is proposed to generate convex and non‐circular particles in a predefined computational domain. Two specific algorithms are developed to handle the contact conformity of generated particles with the boundaries of the computational domain. The first, called the open form, is used to handle the smooth contact of generated particles with (external) boundaries, while the other, called the closed form, is proposed to handle the internal boundaries of a computational domain with a complex cavity. The Gilbert‐Johnson‐Keerthi (GJK) method is used to efficiently solve the contact detection between the newly generated particle at the front and existing particles. Furthermore, the problem of one‐sided particle lifting, which can cause some defects in the packing structure in existing advancing front methods during packing generation, is highlighted and an effective solution is developed. Several examples of increasing complexity are used to demonstrate the efficiency and applicability of the proposed packing generation approach. The numerical results show that the generated packing is not only more uniform, but also achieves a higher packing density than existing advancing front methods.