bluuebunny/crossref_metadata_2025_split huggingface dataset:
CD36 initiates Src signal transduction to promote actin remodeling-involved metastasis of lung adenocarcinoma in high-fat environment
Authors: Liu Lizhong , Wang Bowen , Zhang Rui , Wu Zangshu , Huang Yuxi , Zhang Xiaoyang , Zhou Jiaying , Yi Junbo , Shen Jian , Li Ming-Yue , Dong Ming 
Published: February 2023

Abstract
High-fat environment facilitates the metastasis of lung adenocarcinoma (LUAD) with unknown mechanism. This work aims to reveal the role of fatty acid transporter CD36 in LUAD cell metastasis upon fatty acid oversupply. In human LUAD cells, palmitic acid (PA) treatment promoted CD36 sarcolemmal translocation, where it activated Rac1 and upregulated MMP-9 through Src-Akt/ERK pathway, resulting in redistribution of cortactin, N-WASP and Arp2/3, and finally led to occurrence of finger-like protrusions of actin on cell surface to enhance cell metastasis. Nude mice fed with normal-chew diet (NCD) and high-fat diet (HFD) were subcutaneously injected with scramble/CD36-shRNA stable tranfected-A549 cells respectively. Compared with NCD mice, the HFD group exhibited higher level of blood free fatty acid (FFA) and cholesterol (TC), developed larger xenograft LUAD tumors and enhanced tumor cell metastatic potential in a CD36-dependent manner, which accompanied by obvious sarcolemmal actin remodeling. Consistently, xenografted and tail vein-injected scramble RNA-A549 cells but not CD36-shRNA-A549 in HFD mice formed metastatic LUAD tumors on the lung. Collectively, our finding demonstrates that CD36 initiates the Src signal transduction to induce actin remodeling in high fat environment, which in turn promotes LUAD cell metastasis. Our finding provides valuable targets for prevention and treatment of LUAD.
Dietary diabetes risk reduction score (DDRRs) and the risk of colorectal cancer and adenoma: a case - control study
Authors: Naghshi Niayesh , Mohammadzadeh Milad , Bahrami Alireza , Abdi Fatemeh , Hejazi Ehsan 
Published: February 2023

Abstract
Background
Given the role of insulin resistance in several cancers, we hypothesized that the risk of colorectal cancer and colorectal adenoma may be lessened by following a diet that improves insulin resistance. Therefore, we conducted the current study to examine the association between dietary diabetes risk reduction and the odds of colorectal cancer and colorectal adenoma.
Method
This hospital-based case-control study was conducted on 129 newly diagnosed colorectal cancer patients, 130 newly diagnosed colorectal adenoma cases, and 240 healthy age- and sex-matched hospitalized controls. We used a valid and reliable 148-item food frequency questionnaire (FFQ) to collect the dietary intake of subjects. Multivariate logistic regression was used to estimate the association between DDRRs and the odds of colorectal cancer and adenoma.
Results
After adjusting for confounding variables, individuals in the highest tertile of the DDRR score were 0.13 and 0.22 times less likely to have colorectal cancer (OR = 0.13, 95% CI: 0.06–0.25) and adenoma (OR = 0.22, 95% CI: 0.12–0.41) respectively
Conclusion
Current results demonstrated that a high DDRR score was associated with a lower risk of colorectal cancer and adenoma.
Survival and prognosis of metastatic breast cancer in young women: SEER 2010-2015
Authors: Sun Hongna , Dai Shuang , Xu Junnan , Zhang Weiwei , Sun Tao 
Published: February 2023

Abstract
Although breast cancer in young women (BCYW) is not as common as in older individuals, the incidence of BCYW is increasing. Due to the particular considerations regarding pregnancy, fertility preservation, early menopause, body image, lactation, and quality of life, BCYW deserves unique management. We sought to estimate the survival and prognosis of such patients. In this article, we extracted 9761 primary breast cancer patients' data between 2010 and 2015 from the Surveillance Epidemiology and End Results (SEER) database. We included patients under 70 years and divided them into two groups by age (＜40 vs. 40-69 years). We defined the clinicopathologic characteristics, comprehensively analyzed and compared the OS and BCSS of breast cancer between two age groups among tumor subtypes. Patients under 40 years have longer OS and BCSS than older patients, while these survival benefits are limited in HR+ or/and HER2+ patients, except for TNBC, which needs further investigation. In addition, we developed an efficient predictive nomogram to predict 1-, 3- and 5-year OS of metastatic BCYW. These nomograms can aid oncologists in distinguishing, assessing and evaluating the risk and prognosis of metastatic BCYW, which can help oncologists select the next treatment strategies for BCYW.
High incidence and mortality diseases control is more imperative apart from COVID-19 in China
Authors: Xu Han-You 
Published: February 2023

Abstract
Objective: In order to enhance the health level, treat and cure well all the diseases, especially the high incidence and mortality diseases. So as to save the life and promote the quality of life. The research has been done to find the facts that that much more death caused diseases apart from the COVID-19 have been killing the people even worse at the COVID-19 pandemic time.
Methods: Summarized the data extracted from three public official internet, the National Bureau of Statistics of China, the WHO and the International Diabetes Federation. Found out the health problems and health influenced diseases data apart from the COVID-19 in China. And analysing the data and facts.
Results: Based on the three channels of official internet, check and look up the valuable data, find out the demanded data and reorganize, build new tables. So the concrete facts to show the critical Chinese health problems apart from COVID-19 have been found. The 12 tables have been created and found that in China, the leading causes of death are Cardiovascular diseases, Malignant neoplasms, Respiratory diseases, Diabetes mellitus , injuries. The diseases have not been prevented and cured. The total death in China has been being more and more. The communicable diseases of Viral Hepatitis and Pulmonary Tuberculosis have been being the No.1 and No.2 incidences in Chinese communicable infections. The mortality of Heart Diseases in Chinese rural areas has been being in fast trend of heavier and heavier, from 87.10 in 2008 to 171.36 in 2020 and in recent three years the No. 1 killer in Chinese rural areas. The explosively developed incidence of diabetes mellitus from the year 2000 in 22564.80 cases(in 1000s) exploded into 90045.10 cases(in 1000s) at 2011, and much too more cases developed up to now.
Conclusion: In China, much more works must be done to control the leading causes of death, the diseases incidence and prevalence undermining health, including the Cardiovascular diseases, Malignant neoplasms, Respiratory diseases, Diabetes mellitus, injuries apart from COVID-19, especially the heart diseases in Chinese rural areas has been being the No. 1 killer in recent three years. The communicable diseases of Viral Hepatitis and Pulmonary Tuberculosis must be controlled and prevented. The urgently needed actions to control the leading causes of death, incidence and prevalence apart from COVID-19 in China may be referenced by other countries and international health organizations.
A 12.5 Gb/s 1.38 mW all-inverter-based optical receiver with multi-stage feedback TIA and continuous-time linear equalizer
Authors: Yan Peng , Hong Chaerin , Chang Po-Hsuan , Kang Hyungryul , Annabattuni Dedeepya , Kumar Ankur , Fan Yang-Hang , Liu Ruida , Rady Ramy , Palermo Samuel 
Published: February 2023

Abstract
An optical receiver employs an all-inverter-based front-end design that provides maximum transconductance for a given power supply and allows for ultra-low power consumption. The feedback transimpedance amplifier (TIA) input stage utilizes a multi-stage amplifier to achieve a dramatic increase in feedback resistance and lower input-referred noise. Cascading an inverter-based active inductor continuous-time linear equalizer (CTLE) provides frequency peaking to compensate the input stage TIA that is intentionally designed with a reduced bandwidth to achieve adequate sensitivity at low power. Fabricated in 28 nm CMOS, the 12.5 Gb/s optical receiver achieves -10.7 dBm OMA sensitivity at 0.11 pJ/bit energy efficiency and occupies only 720 μm2 area.
Ensemble Diabetic Retinopathy Detection in 2-D Color Fundus Retina Scan
Authors: Jindal Himanshu , Jain Shruti , Aggarwal Akhit 
Published: February 2023

Abstract
Diabetic Retinopathy (DR) is a burgeoning malady in Asian territories. DR causes 5% to 7% of the total blindness throughout the region. The main aim of this research is to determine whether a patient is suffering from DR or not by the dint of 2-D color fundus retina scans. In this paper authors have proposed a GUI-based technique an Ensemble Diabetic Retinopathy Detection (EDRD). This method helps in detecting 2D color fundus scan with an efficient approach for finding DR-affected persons within a few seconds using ensemble techniques of CNN and RLU. The Visual Geometry Group (VGG-19) model and Adaptive Moment Estimation optimizer is used for training and reducing error for the developed technique. Maximum accuracy of 92% was obtained for 80% training set with 0.001 learning rate and 25 batch size. The proposed research contribution definitively detects whether the given OCT scan with an efficient approach for finding DR affected persons within few seconds.
The Logic of Specialized Division of Labor in the Mariculture Industry:An Inframarginal Analysis Based on External Risks
Authors: Zhang Jiahao 
Published: February 2023

Abstract
The development of the mariculture industry is critical to ensuring global food safety. As a booming industry, its specialized division of labor is continuously evolving to promote its current green transformation. To reveal the formation mechanism of vertical specialization in the mariculture industry and explore the pathways to improving its production efficiency, this paper adds risk factors to the existing inframarginal model to study the mechanism of how production risks affect vertical specialization, analyze the impact of those risks on production efficiency and test the hypothesis by perform the dynamic simulation of industrial division of labor evolution process based on ABM model. The results show that the greater the reduction in production risk brought about by specialization, the more divided the production structure tends to be. Vertical specialization improves the production efficiency of each link, and the lower the risk of specialization in the corresponding production link, the higher the production efficiency tends to be. These findings suggest that the level of specialization in the mariculture industry should be improved by enhancing transaction efficiency and reducing learning costs, multiplying channels to reduce the risks of specialized farming, and improving the risk transfer system.
GSD models for blast propagation]{Two-dimensional geometrical shock dynamics for blast wave propagation and post-shock flow effects
Authors: Liu Heng , Eliasson Veronica 
Published: February 2023

Abstract
Geometrical shock dynamics (GSD) is a numerical model capable of efficiently predicting the position, shape and strength of a shock wave. Compared to the traditional Euler method that solves the inviscid Euler equations, GSD is a reduced-order model derived from the method of characteristics which results in a more computationally efficient approach since it only considers the motion of the shock front instead of the entire flow field. Here, a study of post-shock flow effects in two dimensions has been performed. These post-shock flow effects become increasingly important when modeling blast wave propagation over extended times or distances, i.e. a shock front that decays in speed and that has decaying properties behind it. A comparison between the first-order complete, and fully complete GSD models (point-source GSD and a model that combines PGSD and the shock-shock approximate theory for cylindrical shock reflection off a straight surface, called PGSDSS) reveals the importance of preserving an intact post-shock flow term, which is truncated by the original GSD model, in predicting blast motion. Lagrangian simulations were performed for the case of interaction between two cylindrical blast waves and results were compared to prior experimental work. Results showed an agreement in attenuation of the maximum pressure at the Mach stem, but an overestimation of the Mach stem growth at its early stage by PGSD was observed.
Adolescents’ Beliefs About What Symptoms Constitute Depression: Are More Expansive Definitions Helpful or Harmful?
Authors: Ahuvia Isaac L. , Fox Kathryn R. , Schleider Jessica L. 
Published: February 2023

Abstract
Purpose. What symptoms do people think constitute “depression”? In a mental health literacy framework, knowing more of depression’s nine core symptoms (per formal psychiatric diagnostic criteria) is thought to help people identify and seek help for depression. However, the common-sense model of self-regulation suggests that more expansive beliefs about what symptoms constitute an illness may be maladaptive, whereby viewing more symptoms as characterizing a disorder predicts greater functional impairment.
Methods. We conducted a pair of studies with U.S. adolescents experiencing elevated depression symptoms (total N = 387), collecting data on symptom beliefs and outcomes via online questionnaires.
Results. Adolescents’ beliefs about what symptoms constitute depression varied widely; across both studies, adolescents reported 115 different symptom combinations, and only 42% endorsed all DSM-5 depression symptoms as characterizing the disorder. Adolescents who identified more symptoms as belonging to depression had more severe depression symptoms (p = .004), reported more hopelessness (p = .021), and were more pessimistic about the permanence of depression (p = .007); they were also more likely to rate medication as potentially helpful (p = .001).
Conclusion. These findings simultaneously support and challenge elements of both the common-sense model and the mental health literacy framework. Future research on mental health literacy may examine why adolescents with more psychiatrically-accurate understandings of depression experience worse clinical outcomes. Likewise, future research on the common sense model should explore whether more expansive depression symptom beliefs may be adaptive as well as maladaptive.
Educational innovations in the approach of outpatients to improve health literacy
Authors: Molinari Humberto , Vanin Adriane Aver , Cunha Mariana Lucas Rocha , Brunetto Marcel Luiz , Araujo Amanda Costa 
Published: February 2023

Abstract
Objective: To propose new approaches to improve patients’ health literacy to the treatment for functional dyspepsia and gastritis.
Methods: This is a prospective study with a pre- and post-educational intervention. Patients had their first consultation with the physician and answered the pre-educational intervention questionnaire. Guidance texts and videos were sent to the patients for 3 weeks after the consultation. Finally, patients return to the consultation with the physician and answered to the second questionnaire after the educational intervention.
Results: The sample included 50 patients, 35 female patients (70%). The average age was 55.7 years (15.3 SD). In the post-intervention questionnaire, 82% of patients improved their clinical condition with the treatment, 44% recognized that dietary changes are important for symptoms improvement, 98% of patients understood the videos, 74% of patients believe that the educational intervention could be used for other specialties and 90% of patients would recommend this method for other specialties.
Conclusion: Patient education is an important strategy for a better understanding of their disease and, possibly, improves adherence to their treatment. Besides that, this study used educational tools through guidance texts and educational videos that can be used in clinical practice. This is an easily, accessible and inexpensive tool for health literacy.
Effect of dipeptidyl peptidase-4 inhibitor on the progression of coronary artery disease evaluated by computed tomography in patients receiving insulin therapy for type 2 diabetes mellitus
Authors: Choi Young , Ko Seung-Hyun , Chang Kiyuk , Yoo Ki Dong , Ihm Sang-Hyun 
Published: February 2023

Abstract
Background: We evaluated the effect of a dipeptidyl peptidase-4 inhibitor (DPP-4i) on the progression of obstructive coronary artery disease (OCAD) in patients with type 2 diabetes mellitus (T2DM) receiving insulin therapy.
Methods: Using a multi-center clinical data warehouse, we retrospectively analyzed the patients receiving insulin therapy for T2DM who underwent coronary computed tomography angiography (CCTA) ≥2 times. The patients were divided into two groups according to the presence of DPP-4i prescription between the two CCTA examinations. The prevalence of OCAD (defined as >50% stenosis on CCTA), new revascularization rates, and changes in the coronary calcium score (CCS) were compared between the two groups.
Results: A total of 623 patients were included and a DPP-4i was prescribed to 380 (60.9%) patients. The median time difference between the two CCTAs was 39.0 (17.0–61.4) months. Newly developed OCAD at the follow-up CCTA was detected in 62 (16.3%) patients in the DPP-4i group and 76 (31.3%) patients in the no DPP-4i group (p<0.001). The risk of new OCAD or new revascularization was lower in the DPP-4i group (19.7% vs. 38.7%, p<0.001). After propensity score matching, the prevalence of new OCAD (15.9% vs. 29.5%, p=0.001) and the composite rate of new OCAD or new revascularization (18.7% vs. 37.3%, p<0.001) were lower in the DPP-4i group. The change in CCS per year did not differ significantly between the two groups (9.1 [0.1 – 56.8] vs. 13.5 [0.0 – 78.6], p=0.715).
Conclusion: Add-on DPP-4i therapy would be beneficial in preventing coronary artery disease progression in patients with T2DM receiving insulin therapy.
Trial registration: ClinicalTrials.gov, study number NCT04825795
Accompany Caregivers to Optimize Learning With People Living With a Major Neurocognitive Disorder: a Qualitative Study
Authors: Viscogliosi Chantal , Dame Nathalie , Roy Jordan Mino , Duquette-Laplante Romane , Rahimaly Sarah , Breton Viviane , Chassé Bernard , Couturier Yves , Déry Jessica , Giroux Dominique , Provencher Véronique 
Published: February 2023

Abstract

Background
For caregivers of people living with major neurocognitive disorders (MNCD), adapting methods optimizing learning to a specific situation can be challenging. These methods based on preserved cognitive skills such as procedural memory and implicit recuperation process include errorless learning, spaced retrieval, motor encoding and vanishing cues. This study aimed 1) to obtain a better understanding of factors influencing caregivers’ use of methods optimizing learning, 2) codevelop workshops, a decision tool and accompanying material to support the method’s application based on caregivers needs 3) evaluate the perceived effects of workshops on the application of these methods.
Methods
The first version of the workshops consisted of five - 2 hours meetings. A qualitative methodology with semi-structured individual interviews was adopted. In addition, individual written and collective verbal feedback were collected after each of the group workshop meetings to continuously improve the workshops. A total of 11 caregivers and three healthcare workers gave feedback after each workshop and were interviewed after the last workshop. All the interviews were recorded and transcribed verbatim for the analysis. Thematic content analysis was conducted.
Results
The results showed many facilitators (e.g., ability of the teacher to adapt methods to specific real situations, help to identify person’s capabilities) and barriers (e.g., fluctuation of MNCD symptoms, caregivers' precarious health status) for caregivers’ understanding and utilization of the methods. A decision tool for the utilization of methods optimizing learning was developed and adjusted based on feedback from the participants. Also, positive effects of the workshops were found on caregivers’ everyday life, their preparedness and their relationship with the person living with MNCD.
Conclusion
This study provided a comprehensive understanding of factors influencing caregivers’ understanding and utilization of methods optimizing learning. According to our findings, providing workshops and co-constructed tools to caregivers generate perceived benefits and support their utilization of methods optimizing learning to help them maintain the autonomy of their loved one living with MNCD.
Trial registration
This study was approved (MP-31-2-19-3211) by the Research Ethics Committee of the Centre intégré universitaire de santé et des services sociaux (CIUSSS) de l’Estrie – Centre hospitalier universitaire de Sherbrooke (CHUS).
SER FELIZ: REFLEXÕES SOBRE A FELICIDADE E SEUS IMPERATIVOS
Authors: Oliveira Cremilda Rodrigues , Souza Adelson Matias 
Published: February 2023

Este artigo tem por objetivo compreender os dilemas do ser humano na contemporaneidade, na busca da felicidade em face de seu desejo incessante de experimentar e apreender a vida em sua totalidade. Tarefa espinhosa que transcende às demandas humanas de preencher o seu vazio existencial. Além de investigar as proposições teóricas- eudaimônicas e existencialistas de felicidade embasadas em Sócrates, Platão, Aristóteles, Epicuro, Sponville, Freud e outros; analisa-se a; e a confronta como produto da produção alienável, da imposição social e da compulsão pelo consumismo. Existe a vida feliz? A felicidade é um bem supremo? É possível o viver feliz sem as imposições e as pressões externas? São algumas das questões que pretendemos refletir com o presente estudo.
As concepções educacionais e pedagógicas de Locke e a educação profissional
Authors: Oliveira Jamille de Amorim , Silva Yara Fonseca de Oliveira e 
Published: February 2023

O presente trabalho refere-se a uma pesquisa desenvolvida durante a disciplina Fundamentos da Educação e Linguagem do curso de Pós-Graduação Stricto Sensu do Programa de Pós Graduação Interdisciplinar em Educação, Escola e Tecnologias, da Universidade Estadual de Goiás (UEG) que objetiva compreender o pensamento educacional e pedagógico de John Locke (1632 -1704) e sua relação com a Educação Profissional. Como procedimento metodológico, adotou-se a leitura, análise e interpretação de algumas obras de Locke, bem como, textos escritos por intérpretes lockeanos. Para compreender o significado histórico das obras de Locke implica necessariamente na compreensão do momento histórico em que elas forem produzidas. Para tanto, discorremos sobre a trajetória bibliográfica de Locke; como se davam as relações sociais e as práticas pedagógicas das escolas no século XVII; destacamos o pensamento educacional e pedagógico proposto por Locke e por fim, fizemos um comparativo entre o novo modelo de educação que Locke propôs e a Educação Profissional. Os resultados da pesquisa evidenciaram que as propostas pedagógicas de Locke e a filosofia da Educação Profissional, via Instituto Federal de Educação, contrapõem ao modelo escolástico de educação e preveem uma formação integral humana fundamentada pelo saber omnilateral e empírico, a fim de preparar um indivíduo útil, virtuoso, sábio e moral para exercer seus direitos na coletividade como parte efetiva da construção da sociedade, entendendo-o, portanto, como sujeito da história ao usar a razão como reguladora de suas ações humanas, políticas e profissionais.
Palavras-chaves: Locke; Pensamento Educacional; Praticas Pedagógicas; Educação Profissional.