bluuebunny/crossref_metadata_2025_split huggingface dataset:
Scanning electron microscopy study of the antennal sensilla of cob borer, Stenachroia elongella (Lepidoptera: Pyralidae)
Authors: Nonglait Kasomhung Chanreila Lyngdoh , Das Khirod Sankar , Marwein Cynthia Bansara , Kharthangmaw Joycy Mary , Choudhury Sudipta 
Published: January 2023

AbstractStenachroia elongella is an important pest of maize in Meghalaya, India. To understand the roles of sensory organs in the biological behaviors of this insect, we determined the structure and distribution of sensilla found on the antenna of both male and female S. elongella by scanning electron microscope. The antenna of both sexes is a filiform type, and the overall length of the female antenna is significantly longer than the male antenna. In both sexes, seven types and two subtypes of antennal sensilla are identified; sensilla trichodea, sensilla chaetica, sensilla styloconica, sensilla coeloconica, sensilla auricillica (I, II), sensilla squamiformia and Böhm sensilla. No sexual dimorphism on the specific occurrence of sensilla is observed. Probable functions are discussed based on their external morphology. These results would be helpful for further studies on TEM investigations, electrophysiological recordings, and behavioral studies.Research Highlights
Seven types and two subtypes of antennal sensilla were observed in both male and female Stenachroia elongella.
Morphology and distribution of the antennal sensilla were discussed.
Sexual dimorphism was observed on the overall length of the antenna where the female antenna is longer than the male antenna. No sexual dimorphism was observed on specific occurrences of antennal sensilla.
Hyperinsulinism/hyperammonemia syndrome caused by biallelic SLC25A36 mutation
Authors: Safran Amit , Proskorovski‐Ohayon Regina , Eskin‐Schwartz Marina , Yogev Yuval , Drabkin Max , Eremenko Ekaterina , Aharoni Sarit , Freund Ofek , Jean Matan M. , Agam Nadav , Hadar Noam , Loewenthal Neta , Staretz‐Chacham Orna , Birk Ohad S. 
Published: January 2023

AbstractHyperinsulinism/hyperammonemia (HI/HA) syndrome has been known to be caused by dominant gain‐of‐function mutations in GLUD1, encoding the mitochondrial enzyme glutamate dehydrogenase. Pathogenic GLUD1 mutations enhance enzymatic activity by reducing its sensitivity to allosteric inhibition by GTP. Two recent independent studies showed that a similar HI/HA phenotype can be caused by biallelic mutations in SLC25A36, encoding pyrimidine nucleotide carrier 2 (PNC2), a mitochondrial nucleotide carrier that transports pyrimidine and guanine nucleotides across the inner mitochondrial membrane: one study reported a single case caused by a homozygous truncating mutation in SLC25A36 resulting in lack of expression of SLC25A36 in patients' fibroblasts. A second study described two siblings with a splice site mutation in SLC25A36, causing reduction of mitochondrial GTP content, putatively leading to hyperactivation of glutamate dehydrogenase. In an independent study, through combined linkage analysis and exome sequencing, we demonstrate in four individuals of two Bedouin Israeli related families the same disease‐causing SLC25A36 (NM_018155.3) c.284 + 3A > T homozygous splice‐site mutation found in the two siblings. We demonstrate that the mutation, while causing skipping of exon 3, does not abrogate expression of mRNA and protein of the mutant SLC25A36 in patients' blood and fibroblasts. Affected individuals had hyperinsulinism, hyperammonemia, borderline low birth weight, tonic–clonic seizures commencing around 6 months of age, yet normal intellect and no significant other morbidities. Chronic constipation, hypothyroidism, and developmental delay previously described in a single patient were not found. We thus verify that biallelic SLC25A36 mutations indeed cause HI/HA syndrome and clearly delineate the disease phenotype.
Twelve‐month clinical, functional, and radiological outcomes in patients hospitalized for SARS‐CoV‐2 pneumonia
Authors: Bongiovanni Marco , Barilaro Giuseppe , Bini Francesco 
Published: January 2023

AbstractTo assess long‐term clinical, radiological, and functional follow‐up of patients hospitalized for severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) pneumonia of different grades of severity. Two‐hundred‐thirty and three patients (Group 1, patients needed invasive mechanical ventilation, n = 69; Group 2, patients needed noninvasive mechanical ventilation, n = 78; Group 3, patients needed <12 L/min of O2 supply, n = 96) with a postdischarge follow‐up >12 months were studied. Follow‐up visits, chest computed tomography (CT) scan and pulmonary function tests (diffusing capacity of the lung for carbon monoxide [DLCO], 6‐min walking tests [6MWT], spirometry) were done at 3, 6, and 12 months after discharge. Male sex was more frequent in Group 1 (n = 50, 72.5%) compared with Group 2 (n = 49, 62.5%) and Group 3 (n = 44, 51.2%), p = 0.024. Group 2 patients had more comorbidities and higher BMI compared with others. At Month 12, the main reported symptoms were fatigue (mainly in Group 3) and dyspnea; most symptoms resolved during follow‐up, except brain fog, memory loss, and anosmia/dysgeusia that, when present at Month 3, usually persisted at Month 12. DLCO and 6MWT normalized at Month 12 in almost all patients. Only nine patients (13%) in Group 1 had a normal chest CT at Month 12, while 20 (29%) had >3 abnormalities, compared with 14 (17.9%) in Group 2 and 11 (11.4%) in Group 3, respectively (p = 0.04). Different clinical symptoms persist up to 12 months in patients hospitalized for SARS‐CoV‐2 pneumonia. Despite the persistence of abnormalities at chest CT scan after 12 months, an impairment of pulmonary function persists only in a minority of subjects. A longer follow‐up is needed to assess the evolution of radiological abnormalities in COVID‐19 population.
Inhibition of PIKFYVE kinase interferes ESCRT pathway to suppress RNA virus replication
Authors: Luo Zhen , Liang Yicong , Tian Mingfu , Ruan Zhihui , Su Rui , Shereen Muhammad Adnan , Yin Jialing , Wu Kailang , Guo Jun , Zhang Qiwei , Li Yongkui , Wu Jianguo 
Published: January 2023

AbstractEndosomal sorting complex required for transport (ESCRT) is essential in the functional operation of endosomal transport in envelopment and budding of enveloped RNA viruses. However, in nonenveloped RNA viruses such as enteroviruses of the Picornaviridae family, the precise function of ESCRT pathway in viral replication remains elusive. Here, we initially evaluated that the ESCRT pathway is important for viral replication upon enterovirus 71 (EV71) infection. Furthermore, we discovered that YM201636, a specific inhibitor of phosphoinositide kinase, FYVE finger containing (PIKFYVE) kinase, significantly suppressed EV71 replication and virus‐induced inflammation in vitro and in vivo. Mechanistically, YM201636 inhibits PIKFYVE kinase to block the ESCRT pathway and endosomal transport, leading to the disruption of viral entry and replication complex in subcellular components and ultimately repression of intracellular RNA virus replication and virus‐induced inflammatory responses. Further studies found that YM201636 broadly represses the replication of other RNA viruses, including coxsackievirus B3 (CVB3), poliovirus 1 (PV1), echovirus 11 (E11), Zika virus (ZIKV), and vesicular stomatitis virus (VSV), rather than DNA viruses, including adenovirus 3 (ADV3) and hepatitis B virus (HBV). Our findings shed light on the mechanism underlying PIKFYVE‐modulated ESCRT pathway involved in RNA virus replication, and also provide a prospective antiviral therapy during RNA viruses infections.
A rigid double‐tailed surfactant preparation method and its application in clean fracturing fluid
Authors: Hu Dengping , Wang Rungang , Liu Boying , Bai Xingjia , Zhu Lin 
Published: January 2023

AbstractUsing 1,8‐dihydroxynaphthalene, thionyl chloride and long‐chain tertiary amine as the main raw materials, a facile preparation method and formulation of a rigid double‐tailed surfactant for clean fracturing fluid were developed. The temperature resistance test and the determination of hydrogen spectrum reveal that the clean fracturing fluid with the prepared surfactant as thickener has excellent salt and temperature resistance. The shear viscosity of the best product at 120°C and 170 s−1 is not less than 65 mPa s, which meets the requirements of 25 mPa s for the field construction of clean fracturing fluid.
Fatigue in Long‐Term Head and Neck Cancer Survivors From Diagnosis Until Five Years After Treatment
Authors: Berg Malin , Silander Ewa , Bove Mogens , Johansson Leif , Nyman Jan , Hammerlid Eva 
Published: January 2023

ObjectivesFatigue due to cancer is a challenging symptom that might be long‐lasting after cancer treatment. The aim of this study was to follow the development of fatigue among head and neck cancer (HNC) patients prospectively and longitudinally and to analyze predictors for acute and chronic fatigue.MethodsHNC patients treated with curative intent were included at diagnosis and completed the following questionnaires multiple times, up to 5 years after treatment: the EORTC QLQ‐FA12 for fatigue, EORTC QLQ‐C30, and HNC‐specific EORTC QLQ‐H&N35 together with an anxiety and depression questionnaire. Predictors of fatigue were evaluated at 3 months and 5 years after treatment.ResultsOf the 311 study participants, 74% responded at the 5‐year follow‐up. Physical fatigue was significantly worse 3 months after treatment, while emotional and cognitive fatigue were the worst at diagnosis and at 3 months. All fatigue domains were significantly better after 1 year, and the fatigue scores remained stable from 1 until 5 years after treatment. Three months after chemoradiotherapy, physical fatigue was more significant, but no long‐term differences due to treatment modalities were found. Depression and anxiety were predictors for chronic emotional fatigue, and local HN pain and swallowing problems were predictors for chronic physical fatigue. Better global quality of life at diagnosis was associated with less physical and emotional fatigue.ConclusionFatigue was worst in the short term for HNC patients and improved after 1 year, and long‐term fatigue remained stable up to 5 years after treatment. A few predictors for chronic fatigue were found.Level of Evidence3 Laryngoscope, 133:2211–2221, 2023
Relative importance of influencing factor‐driven soil enzyme activity during the early plantation stage in the hilly‐gully Loess regions
Authors: Wu Huifeng , Hu Baoan , Cheng Xiaoqin , Kang Fengfeng , Han Hairong 
Published: January 2023

AbstractWidespread and rapid land‐use changes have changed the ecosystem structure and threatened soil functions. Soil enzymes are the important driving force and sensitive indicators for soil ecological function. However, the effect of afforestation on soil enzyme activity and the relative importance of the influencing factors (plants, soil, structure, and nutrition) are still inconclusive, especially in the early stage of afforestation. Here, the enzymatic activities and influencing factors of five types of plantations (18 years old) and natural grassland topsoil (0–20 cm) in the hilly‐gully region of the Loess Plateau were studied. The results showed that the soil enzyme activity of the plantations was significantly lower than that of the natural grassland, and the activities of invertase, urease, and alkaline phosphatase were decreased by 32%, 26%, and 10% on average, respectively. Partial correlation analysis and multiple regression analysis showed that the influence of soil and nutrient factors on invertase and alkaline phosphatase was more important than that of plant and structural factors, while urease was more influenced by plant and nutrition factors. Our results suggest that soil and nutrient characteristics were important factors affecting soil enzyme activity in plantations, but the disturbance of vegetation may be the main reason for the decrease in enzyme activity in the early stage of restoration.
Two sisters with cardiac‐urogenital syndrome secondary to pathogenic splicing variant in the MYRF gene with unaffected parents: A case of gonadal mosaicism?
Authors: Slaba Katerina , Jezova Marta , Pokorna Petra , Palova Hana , Tuckova Jana , Papez Jan , Prochazkova Dagmar , Jabandziev Petr , Slaby Ondrej 
Published: January 2023

AbstractBackgroundCardiac‐urogenital syndrome [MIM # 618280] is a newly described very rare syndrome associated with pathogenic variants in the myelin regulatory factor (MYRF) gene that leads to loss of protein function. MYRF is a transcription factor previously associated only with the control of myelin‐related gene expression. However, it is also highly expressed in other tissues and associated with various organ anomalies. The clinical picture is primarily dominated by complex congenital cardiac developmental defects, pulmonary hypoplasia, congenital diaphragmatic hernia, and urogenital malformations.Case PresentationWe present case reports of two siblings of unrelated parents in whom whole‐exome sequencing was indicated due to familial occurrence of extensive developmental defects. A new, previously undescribed splicing pathogenic variant c.1388+2T>G in the MYRF gene has been identified in both patients. Both parents are unaffected, tested negative, and have another healthy daughter. The identical de novo event in siblings suggests gonadal mosaicism, which can mimic recessive inheritance.ConclusionsTo our knowledge, this is the first published case of familial cardiac‐urogenital syndrome indicating gonadal mosaicism.
A universal UHF near‐field RFID reader antenna with wide bandwidth and adjustable reading area
Authors: Ye Xiaohui , Liu Qiang , Zhang Chen , Li Guolin , Du Guangxing , Cheng Dong 
Published: January 2023

AbstractA universal ultrahigh‐frequency (UHF) near‐field radio‐frequency identification (RFID) reader antenna with wide bandwidth and adjustable reading area is proposed in this letter. The antenna consists of an inverting power splitter base on double‐sided parallel stripline and adjustable traveling‐wave near‐field radiation units, which consists of two symmetrical meander microstrips and a complementary open resonant ring loaded on the ground plane. A design example with three radiation units is simulated, fabricated, and tested for verification. The result indicates that the proposed antenna has the 10‐dB impedance bandwidth of 128%, which completely covers the universal UHF RFID band from 840 to 960 MHz. The 100% read–write rate is achieved within the read–write distance of 10 mm according to the reading test. The reading area of 731 × 120 mm2 can be obtained for increasing the number of radiation units to 10. Moreover, the antenna features low far‐field gain, low‐cost, strong and uniform magnetic field distribution. Therefore, the proposed antenna and design method have good application prospects in the Internet of Things.
Deep compressed sensing MRI via a gradient‐enhanced fusion model
Authors: Dai Yuxiang , Wang Chengyan , Wang He 
Published: January 2023

AbstractBackgroundCompressed sensing has been employed to accelerate magnetic resonance imaging by sampling fewer measurements. However, conventional iterative optimization‐based CS‐MRI are time‐consuming for iterative calculations and often share poor generalization ability on multicontrast datasets. Most deep‐learning‐based CS‐MRI focus on learning an end‐to‐end mapping while ignoring some prior knowledge existed in MR images.PurposeWe propose an iterative fusion model to integrate the image and gradient‐based priors into reconstruction via convolutional neural network models while maintaining high quality and preserving the detailed information as well.MethodsWe propose a gradient‐enhanced fusion network (GFN) for fast and accurate MRI reconstruction, in which dense blocks with dilated convolution and dense residual learnings are used to capture abundant features with fewer parameters. Meanwhile, decomposed gradient maps containing obvious structural information are introduced into the network to enhance the reconstructed images. Besides this, gradient‐based priors along directions X and Y are exploited to learn adaptive tight frames for reconstructing the desired image contrast and edges by respective gradient fusion networks. After that, both image and gradient priors are fused in the proposed optimization model, in which we employ the l2‐norm to promote the sparsity of gradient priors. The proposed fusion model can effectively help to capture edge structures in the gradient images and to preserve more detailed information of MR images.ResultsExperimental results demonstrate that the proposed method outperforms several CS‐MRI methods in terms of peak signal‐to‐noise (PSNR), the structural similarity index (SSIM), and visualizations on three sampling masks with different rates. Noteworthy, to evaluate the generalization ability, the proposed model conducts cross‐center training and testing experiments for all three modalities and shares more stable performance compared than other approaches. In addition, the proposed fusion model is applied to other comparable deep learning methods. The quantitative results show that the reconstruction results of these methods are obviously improved.ConclusionsThe gradient‐based priors reconstructed from GFNs can effectively enhance the edges and details of under‐sampled data. The proposed fusion model integrates image and gradient priors using l2‐norm can effectively improve the generalization ability on multicontrast datasets reconstruction.
Multi‐echo dipole inversion for magnetic susceptibility mapping
Authors: Kames Christian , Doucette Jonathan , Rauscher Alexander 
Published: January 2023

PurposeReconstructing tissue magnetic susceptibility (QSM) from MRI phase data involves solving multiple consecutive ill‐posed inverse problems such as phase unwrapping, background field removal, and field‐to‐source inversion. Multi‐echo acquisitions present an additional challenge, as the magnetization field is typically computed from the multiple phase data prior to reconstructing the susceptibility map. Processing the multiple phase data introduces errors during the field estimation, violating assumptions of the subsequent inverse problems, manifesting as streaking artifacts in the susceptibility map. To address this challenge, we propose a multi‐echo field‐to‐source forward model that forgoes the field estimation step. Moreover, we propose a fully general underestimation correction step to recover susceptibility sources that were regularized away during the field‐to‐source inversion.MethodsThe multi‐echo forward model and correction step were validated on the QSM Challenge 2.0 datasets and compared to the standard single field‐to‐source model in in vivo human brains using different types of deconvolution algorithms.ResultsOn the QSM Challenge 2.0 datasets the multi‐echo forward model and correction step attain state‐of‐the‐art results on all metrics by a wide margin. Experiments in in vivo brains show that the multi‐echo model is in agreement with the single field‐to‐source model and that the proposed forward model and correction step can be used with any available dipole inversion method.ConclusionA multi‐echo field‐to‐source forward model forgoes the need to fit multi‐echo phase data and achieves state‐of‐the‐art results on the QSM Challenge 2.0 data. Underestimated low‐frequency susceptibility distributions can be partially recovered using a correction step.
Robot‐assisted laparoscopic cystectomy with non‐continent urinary diversion for neurogenic lower urinary tract dysfunction: Midterm outcomes
Authors: Calën Laura , Mesnard Benoît , Hedhli Oussama , Broudeur Lucas , Reiss Bénédicte , Loubersac Thomas , Branchereau Julien , Baron Maximilien , Rigaud Jérôme , Le fort Marc , Perrouin‐Verbe Brigitte , Le Normand Loïc , Lefevre Chloé , Perrouin‐Verbe Marie‐Aimée 
Published: January 2023

AbstractObjectivesThe aim of this study was to assess midterm functional outcomes and complications of robot‐assisted laparoscopic cystectomy with non‐continent urinary diversion in patients with neurogenic lower urinary tract dysfunction.Materials and MethodsWe performed a retrospective single center study including all patients who underwent robot‐assisted laparoscopic cystectomy with non‐continent urinary diversion between January 2008 and December 2018 for neurogenic lower urinary tract dysfunction. Perioperative data, early and late complications, reoperation rate, renal function, and patient satisfaction (PGI‐I) were evaluated.ResultsOne hundred and forty patients were included (70 multiple sclerosis, 37 spinal cord injuries, 33 others) with a median follow‐up of 29 months (12−49). The main indication for surgery was an inability to perform intermittent self‐catheterization (n = 125, 89%). The early complication rate (<30 days) was 41% (n = 58), including 72% (n = 45) minor complications (Clavien I−II) and 29% (n = 17) major complications (Clavien III−V). Three patients died in the early postoperative period. Late complications appear in 41% (n = 57), with 9% (n = 13) being ureteroileal anastomotic stricture. The overall reintervention rate was 19% (n = 27), mainly for lithiasis surgery. Pre‐ and postoperative renal function were comparable. Most of patients reported an improvement in their quality of life following their surgery (PGI‐I 1−2).ConclusionRobot‐assisted laparoscopic cystectomy with non‐continent urinary diversion may be of particular interest in patients with neurogenic lower urinary tract dysfunction who are unable to benefit from conservative treatment, as it provides midterm protection of the upper urinary tract and an improvement in quality of life.
Influence of workplace stress and social support on humanistic caring ability in Chinese nurses
Authors: Dong Faqin , Huang Weiping , Chu Chunfei , Lv Lu , Zhang Min 
Published: January 2023

AbstractAimThis study aimed to examine the relationships between how workplace stress and social support affect the level of humanistic caring ability in Chinese nurses.DesignA cross‐sectional study.MethodsThe sample consists of 675 nurses working in major hospitals in China. Participants completed a set of self‐reported measures, including the humanistic caring ability scale (HCAS), the Chinese nurse workplace stressor scale (CNWSS), the Chinese nurse stress response scale (CNSRS), and the Chinese nurse social support scale (CNSSS). Pearson's correlation analysis and structural equation modelling (SEM) were performed to investigate the relationships among studied variables.ResultsThe result showed that HCAS was negatively correlated with CNWSS (r = −0.427, p < 0.01) and CNSRS (r = −0.480, p < 0.01), and was positively correlated with CNSSS (r = 0.363, p < 0.01). Furthermore, a final model was conducted in which CNWSS has a strong direct effect on CNSRS (β = 0.54, p < 0.01) and an indirect effect on HCAS (β = −0.138, p < 0.01), which was mediated by CNSRS and CNSSS.