bluuebunny/crossref_metadata_2025_split huggingface dataset:
Compromised Outcomes in Stage IV Non–Small-Cell Lung Cancer With Actionable Mutations Initially Treated Without Tyrosine Kinase Inhibitors: A Retrospective Analysis of Real-World Data
Authors: Scott Jeffrey A. , Lennerz Jochen , Johnson Melissa Lynne , Gordan Lucio N. , Dumanois Robert H. , Quagliata Luca , Ritterhouse Lauren L. , Cappuzzo Federico , Wang Brandon , Xue Mei , Vasudevan Anupama , Varughese Prateesh , Vaidya Varun , Gart Mike , Dorrow Natalie , Gierman Hinco J. , Choksi Rushir J. 
Published: August 2023

PURPOSE Identification and targeting of actionable oncogenic drivers (AODs) in advanced non–small-cell lung cancer (NSCLC) has dramatically improved outcomes. However, genomic testing uptake is variable and hampered by factors including slow turnaround time, frequently resulting in initial non–tyrosine kinase inhibitor (TKI) treatment. We investigate how this behavior affects outcomes. METHODS This retrospective analysis of real-world, deidentified data from the Integra Connect Database included adults with stage IV NSCLC newly diagnosed from January 1, 2018, to December 31, 2020, with mutations of EGFR, ALK, ROS1, BRAF, MET, RET, ERBB2, or NTRK. Outcomes were reported as time to next treatment or death (TTNT) and overall survival (OS). RESULTS Five hundred ten patients harboring AODs were identified and grouped as follows: group A (n = 379) were treated after the AOD was reported and served as the comparator. One hundred thirty-one patients treated before their AOD report were divided into group B (n = 47) who were initially started on chemotherapy and/or checkpoint inhibitor but switched to appropriate TKI within 35 days and group C (n = 84) who were also started empirically on non-TKI and did not switch within 35 days. Survival (OS) was significantly superior in group A compared with group C; TTNT was significantly superior in group A compared with groups B and C. CONCLUSION For patients harboring AODs in advanced NSCLC, initial treatment before receipt of genomic test results yields significantly inferior outcomes and should be avoided. Molecular profiling panels with rapid turnaround times are essential to optimize patient outcomes and should be standard of care.
Severe Hypercalcemia Due to Primary Hyperparathyroidism and Heterozygous Pathogenic Variant of CYP24A1
Authors: Liu Jannel , Angelos Peter , Barhoum Maan , Jain Rajesh 
Published: August 2023

Abstract
Pathogenic variants of CYP24A1 are associated with hypercalcemia due to disruptions in the ability of 24-hydroxylase to break down 1,25-dihydroxyvitamin D (1,25-DHVD). A case involving a heterozygous pathogenic variant of CYP24A1 and primary hyperparathyroidism leading to severe hypercalcemia has not been previously reported. A 23-year-old woman presented with fatigue and was found to be hypercalcemic at 13.8 mg/dL [reference range, 8.4-10.2 pg/mL]. Her parathyroid hormone (PTH) was 62 pg/mL [reference range, 19-88 pg/mL] and 1,25-DHVD was elevated to 242.7 pg/mL [reference range, 18-72 pg/mL]. Other laboratory workup was unrevealing. She had a bone scan, whole body CT scan, and thyroid ultrasound that were normal. Her 25-hydroxy-vitamin D to 24,25-dihydroxy-vitamin D ratio was elevated at 25.18 (normal, &lt; 25). Because of concern for primary hyperparathyroidism, she was referred to an endocrine surgeon and underwent a parathyroidectomy with the removal of a 3.5-gram adenoma. Pathology showed a parafibromin-deficient parathyroid neoplasm. Genetic testing demonstrated a heterozygous pathogenic variant in CYP24A1. Three weeks after surgery, PTH was 14 pg/mL (1.48 pmol/L), calcium and 1,25-DHVD normalized. In summary, we report a case where a patient with severe symptomatic hypercalcemia was found to have primary hyperparathyroidism exacerbated by an underlying heterozygous pathogenic variant in CYP24A1.
Rare Case of Pseudohypoparathyroidism With Normocalcemia Because of a Novel GNAS Mutation
Authors: Mangu Goutami , Malik Sonika , Eranki Vijay 
Published: August 2023

Abstract
PTH resistance is characterized by hypocalcemia and hyperphosphatemia in the presence of elevated PTH concentrations, resulting in pseudohypoparathyroidism, which is subdivided into different types according to its different pathogenesis and phenotype. PTH receptor is the alpha subunit of stimulatory G protein (Gsα)-coupled receptor. Pathogenic variants of GNAS gene, encoding for Gsα, lead to reduced Gsα function and PTH resistance. We report a patient with PHP type 1a, with no documented evidence of hypocalcemia, presenting with AHO phenotype and multihormone resistance to PTH, TSH, and GnRH. Her genetic testing showed a novel heterozygous pathogenic variants, a c.934T &gt; G change in exon 11 in adenylate cyclase stimulatory G protein that has not been reported in the literature so far.
«DRAGON, LOTUS, PHOENIX» AS SPECIAL SYMBOLS OF CHINA CULTURE
Authors: He Cao 
Published: August 2023

At present, the urgent task is to preserve and broadcast the cultural values of different peoples. From this point of view, symbols of Chinese benevolent culture can be seen as an important form of cultural communication. Three symbols of good wishes were chosen as the objects of the study: dragon, lotus and phoenix. Despite the prevalence of these images, there are practically no works in the literature that comprehensively, from different points of view, would describe the semantics of each of them. Thus, the goal is to reveal the history of these symbols, their meaning and traditions of use in a benevolent culture. The author identified and systematized the main images and meanings of the three symbols of Chinese culture. Based on the results of the work, the author came to the conclusion that all three symbols have a number of hidden images and meanings that can vary depending on the way they are depicted, and also have opposite meanings when combined with other symbols (for example, a dragon combined with a phoenix).
Purpose. The article considers the symbolism of the benevolent culture of the PRC, as one of the connecting threads in the development of Chinese identity. The symbolism is illustrated by examples of some of the most common images used in jade art – the dragon, lotus and phoenix. The author aims to reveal the history of the use of these images, their symbolism and traditions of use in a benevolent culture.
Methodology. The research is based on hermeneutic, comparative and axiological methods.
Results. The results of the work are that the author identified and systematized the main images and meanings of the three symbols of Chinese culture: the dragon, the phoenix and the lotus.
Practical implications. The results of the study can be used in the educational process when teaching courses on the history and culture of China, including history, art history, oriental culture, sinology, etc. The study of the cultural values of China, in particular, the symbolism of auspicious ornaments, allows you to broadcast, preserve and transmit the history and traditions of the art of the Middle Kingdom.
Bronchopulmonary dysplasia – a new perspective on prevention and treatment
Authors: Grabarczyk Aleksandra , Jaremek Anna , Kępa Joanna , Kandefer Norbert , Wyszkowski Michał , Pawlak Anna , Grad Sylwia , Gregorek Małgorzata , Gregorek Paweł 
Published: August 2023

Introduction
Premature birth is one of the most common problems in neonatal care and affects from 6 to 14% of pregnancies (frequency depends on geographical factors) [1]. Prematurity is the cause of almost half of deaths of children younger than 5 years old [3]. The most frequent and one of the most severe risks of preterm births is bronchopulmonary dysplasia (also called a chronic lung disease in some sources).
Aim of the study
The aim of this study is to collect data on both new and traditional ways of prevention and treatment of chronic lung disease in a population of infants born preterm (<37 weeks of gestational age).
Materials and methods
The work was created based on the articles available in PubMed and Google Scholar databases and available scientific literature. Publications were searched in English and Polish using the following keywords: bronchopulmonary dysplasia, chronic lung disease of the newborns, pulmonary hypertension in bronchopulmonary dysplasia, stem cells in bronchopulmonary dysplasia.
Results
Although bronchopulmonary dysplasia is a common problem among children born preterm, there is still a limited amount of possibilities of prevention and treatment of this condition. Despite efforts of scientists, many children with this condition suffer from both short-term and long-term consequences, such as frequent infections, asthma and impaired growth and neurodevelopment.
Summary
In the last twenty years the survival rate of children born preterm rapidly increased thank to the development of neonatal care. Up to 20% of children born with body weight less than 1500g will develop bronchopulmonary dysplasia. That is why there is a need for further research on the topic of bronchopulmonary dysplasia management, especially when it comes to biomarkers, use of mesenchymal stem cells and treatment of pulmonary hypertension.
On the Distributed Energy Storage Investment and Operations
Authors: Wu Owen Q. , Kapuscinski Roman , Suresh Santhosh 
Published: August 2023

Problem definition: Energy storage has become an indispensable part of power distribution systems, necessitating prudent investment decisions. We analyze an energy storage facility location problem and compare the benefits of centralized storage (adjacent to a central energy generation site) versus distributed storage (localized at demand sites). This problem encompasses optimizing storage capacities across all locations, with the objective of minimizing the total storage investment and energy generation costs. Methodology/results: We employ a stylized model that captures essential features of an energy distribution system, including convex costs, stochastic demand, storage efficiency, and line losses. Using dynamic programming, we optimize storage operations and derive value function properties that are key to analyzing the storage investment decisions. We discern fundamental differences between centralization/localization decisions at the capacity investment stage and the centralization/localization decisions at the storage operations level. Operationally, centrally stored energy offers more flexibility, which is consistent with the conventional understanding of inventory pooling. However, we find that localized storage often emerges as the preferred option at the investment stage under various circumstances. Managerial implications: Storage investment should first be made at the demand locations with positive minimum demand regardless of the level of demand variability. Subsequent storage investment should consider the tradeoffs between centralized versus localized investment. Operationally, the relative magnitudes of storage and line losses drive different optimal storage policies. Despite the differences, these policies are guided by common principles such as pooling inventory and balancing local storage levels. Supplemental Material: The online appendices are available at https://doi.org/10.1287/msom.2020.0652 .
LETRAMENTO EM REDE: PROPOSTA METODOLÓGICA COMO CAMINHO PARA REFLEXÕES SOBRE FAKE NEWS
Authors: Vieira da Silva Márcia Maria , Souza da Silva (Betonasi) André Luiz , Dos Santos Amaral Cláudia Norberta , Borges Sales Kathia Marise , Brito das Mercês Uilma 
Published: August 2023

Este artigo apresenta uma reflexão sobre o letramento em redes sociais buscando ampliar o entendimento acerca do letramento digital como fenômeno social, bem como compreender como as redes sociais digitais se configuram enquanto instrumentos para prática de letramento. A partir desse pressuposto, este estudo apresenta o resultado da aplicação de uma proposta metodológica conduzida por meio de uma live, na plataforma youtube, com o intuito de fomentar reflexões sobre os impactos das fake news nas redes sociais, como prática de letramento em rede, já que o volume de informações muda constantemente. Este trabalho foi construído a partir de pesquisas bibliográficas e está embasado em referenciais teóricos postulados por Santaella (2013), Dudeney, Hockly e Pegrum (2016), Coscarelli (2017), Rojo (2013), Castells (1999, 2003), Filho (2018), entre outros. Após a experiência da live e o feedback das atividades postadas pelos partícipes, foi possível verificar o envolvimento dos mesmos com a proposta da atividade. Constatou-se que os participantes reconhecem a importância de se alertar as pessoas sobre os impactos nocivos das fake news na sociedade. Nesse sentido, as considerações pautadas neste trabalho, que visa práticas pedagógicas moduladas na utilização das tecnologias digitais, se apresentam como caminho promissor para (re)pensar a educação e, consequentemente, as ações mediadas nas ambiências digitais. De forma dinamizada, os participes foram conduzidos ao reconhecimento das novas relações e desafios que os acompanham quando entram em interatividade no ciberespaço, construindo, assim, competências promissoras para lidar com as informações veiculadas no universo digital.
A CULTURA DIGITAL E ESCOLARIZAÇÃO INDÍGENA: A EXPERIÊNCIA TUPINAMBÁ NO ACUÍPE DE BAIXO
Authors: Braga Ana Cláudia Vieira , Santos Gilberto Lacerda 
Published: August 2023

Esse artigo tem por objetivo apresentar o diagnóstico situacional produzido por meio de uma pesquisa exploratória, realizada no Colégio Estadual Indígena Tupinambá do Acuípe de Baixo, localizado no distrito de Olivença na região municipal de Ilhéus no Estado da Bahia, para investigar aspectos sociais, pedagógicos, administrativos, documentais, institucionais que colaborem para o aprofundamento teórico da relação entre cultura digital e cultura indígena e na coleta de informações prévias disponíveis a respeito. A metodologia utilizada foi a análise situacional da pesquisa exploratória e a pesquisa bibliográfica para o levantamento do referencial teórico. Os resultados foram obtidos por meio de entrevistas semiestruturadas com os agentes educacionais que tiveram experiências práticas com o problema pesquisado; análise do projeto pedagógico da escola indígena; diagnose social da escola e a elaboração de um estado da arte sobre inclusão digital indígena e práticas da educação mediada por Tecnologias Digitais de Informação, Comunicação e Expressão (TICE). A partir dos dados coletados na pesquisa exploratória foi possível realizar uma diagnose social do Colégio Indígena Tupinambá do Acuípe de Baixo e investigar aspectos sociais, pedagógicos, administrativos, documentais e institucionais que colaborassem para uma exploração de informações iniciais a respeito da inclusão digital em um colégio indígena Tupinambá. PALAVRAS-CHAVE: Cultura Digital. Escolarização indígena. Inclusão digital. TICE.
ANÁLISE DO WEBSITE DO POVO ASHANINKA DO RIO AMÔNIA: TECENDO SABERES NO CIBERESPAÇO PARA A INTERCULTURALIDADE
Authors: Moura Sonaira De Araújo , Guedes Luiz Eduardo , Da Silva Bento Duarte 
Published: August 2023

Este trabalho é parte de uma dissertação de mestrado desenvolvida no Programa de Pós-Graduação em Ciências da Educação, na especialidade de Tecnologia Educativa, pela Universidade do Minho (Portugal), cujo projeto de pesquisa tinha por objetivo principal compreender o cenário de integração das tecnologias de informação e comunicação (TIC) na educação dos povos indígenas do Brasil e o contexto desta integração no caso específico do povo Ashaninka do rio Amônia. Neste texto apresentamos uma parte da pesquisa, a que diz respeito à análise do website do povo Ashaninka como um etno-espaço que possibilita a tessitura de saberes no ciberespaço para a interculturalidade. Porém, antes dessa análise, para contextualizarmos a temática, faremos uma breve incursão sobre as políticas de inclusão digital dos povos indígenas e o protagonismo indígena no uso da internet. Partindo depois para a abordagem do website do povo Ashaninka, fazemos a análise do seu conteúdo e do design gráfico da interface recorrendo a critérios de usabilidade recomendados pela literatura do webdesign. Os resultados apontam que a comunidade indígena vem introduzindo as TIC como uma janela para o mundo intercultural, possibilitando construir saberes entre não indígenas e o povo Ashaninka, visando romper com estereótipos e preconceitos que estigmatizam as populações indígenas, a partir da divulgação da sua cultura, espiritualidade, artes e tradições.
DO CAPIM DOURADO AO GEOGEBRA: A GEOMETRIA PRESENTE NOS ARTESANATOS AKWĒ-XERENTE
Authors: De Sousa Wesley Coelho , Aparecida Pereira de Melo Elisângela 
Published: August 2023

O povo indígena Akwē˗Xerente, localizado no estado do Tocantins, desenvolve diversas atividades oriundas de sua cultura originária, dentre elas, a confecção de artesanatos com as fibras de capim dourado, que evidenciam aspectos geométricos; essa evidência de aspectos pode ser utilizada em sala de aula para o ensino da Matemática. Com base nesse contexto sociocultural, este texto tem como objetivo refletir sobre as práticas educacionais para o ensino de Geometria Euclidiana Plana por meio das relações entre a Etnomatemática, as Tecnologias Digitais e os aspectos geométricos identificados em uma cestaria produzida pelas artesãs Akwē˗Xerente. Para tanto, adota-se, como caminho metodológico, a abordagem qualitativa da pesquisa etnográfica, sendo um desdobramento de uma investigação mais ampla que está sendo desenvolvida no curso de mestrado acadêmico do Programa de Pós-graduação em Ensino de Ciências e Matemática (PPGecim), da Universidade Federal do Norte do Tocantins (UFNT). Como resultado, constatou-se a possibilidade de explorar as Tecnologias Digitais para potencializar o ensino e a aprendizagem da Matemática no contexto indígena por meio do uso do software GeoGebra.
PRINCÍPIOS DE ORGANIZAÇÃO CURRICULAR DA GEOGRAFIA NO ENSINO FUNDAMENTAL 1
Authors: Couto Marcos Antonio Campos 
Published: August 2023

O objetivo do texto é debater os critérios de montagem de programas e currículos da Geografia na Educação Básica, com foco no currículo do primeiro seguimento, 1º ao 5º anos, do Ensino Fundamental. A metodologia parte da crítica da Base Nacional Comum Curricular que, em seguida, é confrontada por propostas alternativas. No final, são retomadas as teses teóricas gerais da concepção histórico-crítica do ensino de geografia, que fundamentam os princípios de organização curricular propostos. Palavras-chave: ensino de geografia; pedagogia histórico-crítica; materialismo histórico-dialético.
Development of a clinical questionnaire to support contraception decisions in an adolescent reproductive health clinic in Colorado
Authors: Hoopes Andrea J. , Akers Aletha Y. , Jimenez‐Zambrano Andrea , Cain Sarah , Maslowsky Julie , Sheeder Jeanelle 
Published: August 2023

AbstractContextAdolescents need support to make informed decisions about contraception. Few clinical questionnaires exist to help adolescents and their healthcare providers align contraception decisions with patient needs and preferences.MethodsOur mixed‐methods study involved a convenience sample of English‐speaking, female patients aged 13–19 seeking contraception services at an adolescent reproductive health clinic in Colorado, USA. Qualitative interviews informed development of clinical questionnaire items. The questionnaire elicited demographic characteristics, pregnancy and contraception use history, preferred contraception attributes, peer and family involvement, healthcare information and support needs, motivations for contraceptive use, and barriers to contraceptive services. We identified key decision‐making factors and reduced the number of questionnaire items through principal components analysis. Using multivariable analyses, we examined the correlation between questionnaire responses and current contraceptive method.ResultsTwenty individuals participated in interviews and 373 individuals completed the preliminary questionnaire with 63 candidate items. We identified five contraceptive decision‐making factors: side‐effect avoidance (eight items, Cronbach's alpha = 0.84), preferred method attributes (six items, Cronbach's alpha = 0.67), parental involvement (three items, Cronbach's alpha = 0.67), life goals prior to parenting (four items, Cronbach's alpha = 0.88), and access to a contraceptive provider (two items, Cronbach's alpha = 0.92) and nine stand‐alone items. In multivariable analyses, we found that questionnaire responses for decision‐making factors varied among participants using different contraceptive methods.ConclusionsMultiple priorities may influence adolescent contraceptive decisions. This clinical questionnaire can elicit these priorities before or during a healthcare encounter. Future studies should assess generalizability of the questionnaire and examine impact on method choice, continuation, satisfaction, and reproductive health outcomes.
Deep serological profiling of the Trypanosoma cruzi TSSA antigen reveals different epitopes and modes of recognition by Chagas disease patients
Authors: Romer Guadalupe , Bracco Leonel A. , Ricci Alejandro D. , Balouz Virginia , Berná Luisa , Villar Juan C. , Ramsey Janine M. , Nolan Melissa S. , Torrico Faustino , Kesper Norival , Altcheh Jaime , Robello Carlos , Buscaglia Carlos A. , Agüero Fernán 
Published: August 2023

Background
Trypanosoma cruzi, the agent of Chagas disease, displays a highly structured population, with multiple strains that can be grouped into 6–7 evolutionary lineages showing variable eco-epidemiological traits and likely also distinct disease-associated features. Previous works have shown that antibody responses to ‘isoforms’ of the polymorphic parasite antigen TSSA enable robust and sensitive identification of the infecting strain with near lineage-level resolution. To optimize the serotyping performance of this molecule, we herein used a combination of immunosignaturing approaches based on peptide microarrays and serum samples from Chagas disease patients to establish a deep linear B-cell epitope profiling of TSSA.

Methods/Principle findings
Our assays revealed variations in the seroprevalence of TSSA isoforms among Chagas disease populations from different settings, hence strongly supporting the differential distribution of parasite lineages in domestic cycles across the Americas. Alanine scanning mutagenesis and the use of peptides of different lengths allowed us to identify key residues involved in antibody pairing and the presence of three discrete B-cell linear epitopes in TSSAII, the isoform with highest seroprevalence in human infections. Comprehensive screening of parasite genomic repositories led to the discovery of 9 novel T. cruzi TSSA variants and one TSSA sequence from the phylogenetically related bat parasite T. cruzi marinkellei. Further residue permutation analyses enabled the identification of diagnostically relevant or non-relevant substitutions among TSSA natural polymorphisms. Interestingly, T. cruzi marinkellei TSSA displayed specific serorecognition by one chronic Chagas disease patient from Colombia, which warrant further investigations on the diagnostic impact of such atypical TSSA.

Conclusions/Significance
Overall, our findings shed new light into TSSA evolution, epitope landscape and modes of recognition by Chagas disease patients; and have practical implications for the design and/or evaluation of T. cruzi serotyping strategies.