bluuebunny/crossref_metadata_2025_split huggingface dataset:
Serum aspartate aminotransferase is an adverse prognostic indicator for patients with resectable pancreatic ductal adenocarcinoma
Authors: He Meifang , Liu Yin , Huang Hefei , Wu Jiali , Wu Juehui , Wang Ruizhi , Wang Dong 
Published: April 2023

Abstract

Objective
In this study, the association between preoperative levels of serum liver enzymes and overall survival (OS) was evaluated in patients with resectable pancreatic cancer.

Methods
Preoperative serum levels of alanine aminotransferase (ALT), aspartate aminotransferases (AST), γ-glutamyltransferase, alkaline phosphatase, and lactate dehydrogenase of 101 patients with pancreatic ductal adenocarcinoma (PDAC) were collected. Univariate and multivariate Cox hazard models were used to identify independent variables associated with OS in this cohort.

Results
Patients with elevated AST levels had significantly worse OS than patients with lower AST levels. A nomogram was created using TNM staging and AST levels and was shown to be more accurate in prediction than the American Joint Committee on Cancer 8th edition standard method.

Conclusion
Preoperative AST levels could be a novel independent prognostic biomarker for patients with PDAC. The incorporation of AST levels into a nomogram with TNM staging can be an accurate predictive model for OS in patients with resectable PDAC.
Resilient Prescribing: An Approach to Psychotropic Use in Deployed Environments
Authors: van Schalkwyk Gerrit I , Parker Trisha N , Horne Jenna G , Agapoff Jame A 
Published: April 2023

ABSTRACT
Resilient prescribing is an approach to the use of psychotropics that considers the significance of the treatment beyond the direct effects of the medication. Within this strengths-based approach, those who are prescribed medications must retain a sense of self-efficacy, understand the importance of their own actions in their recovery, have reasonable expectations of what a medication can and cannot do, and avoid the adoption of a disempowering illness identity. These constitute the principles of resilient prescribing. In this manuscript, we explore these principles with consideration for how they may be applied in deployed settings where the ability of service members to recover from behavioral health concerns is mission critical. These principles offer a roadmap to prescribing that builds upon the service members’ own strengths and has the potential to amplify the positive impacts of mental health treatment.
Enterocytozoon bieneusi and Encephalitozoon intestinalis (microsporidia) in HIV-positive patients in central Spain
Authors: Chozas Mercedes , Dashti Alejandro , Prieto-Pérez Laura , Pérez-Tanoira Ramón , Cobo Elena , Bailo Begoña , del Palacio Marta , Hernández-Castro Carolina , González-Barrio David , Carmena David , Köster Pamela C 
Published: April 2023

Abstract
Microsporidia are fungi-related eukaryotic intracellular parasites that opportunistically infect immunocompromised individuals such as those infected by the human immunodeficiency virus (HIV). Among them, Enterocytozoon bieneusi and Encephalitozoon spp. are the most clinically relevant species. We investigated the occurrence and genetic diversity of microsporidial and protist infections in mostly immunocompetent HIV-positive patients in Madrid, Spain. A structured questionnaire was used to retrieve data on factors potentially associated with an increased risk of infection, including sexual attitudes and sex-risk behaviour. Faecal samples (n = 96) from 81 HIV-positive patients were collected and analysed by molecular (PCR and Sanger sequencing) methods. Two microsporidial pathogens were detected: Ent. bieneusi (2.5%, 95% CI: 0.3–8.6) and Enc.intestinalis (4.9%, 95% CI: 1.4–12.2). The two Ent. bieneusi isolates were identified as zoonotic genotype A. Among protists, Entamoeba dispar was the species most prevalently found (33.3%, 95% CI: 23.2–44.7), followed by Blastocystis spp. (19.8%, 95% CI: 11.7–30.1), Giardia duodenalis (13.6%, 95% CI: 7.0–23.0), and Cryptosporidium spp. and Entamoeba histolytica (2.5%, 95% CI: 0.3–8.6 each). Cyclospora cayetanensis and Cystoisospora belli were not detected. Subtypes ST1 (70.6%, 12/17) and ST3 (29.4%, 5/17) were identified within Blastocystis sp., sub-assemblages AII and BIII (50%, 1/2 each) within G. duodenalis, and Cry. parvum and canine-adapted Cry. canis (50%, 1/2 each) within Cryptosporidium spp. Microsporidial and protist parasites were frequent in well-controlled, mostly immunocompetent HIV-positive patients and should be included in diagnostic algorithms when diarrhoea is present.
HST PanCET programme: a flat optical transmission spectrum for the Hot Jupiter WASP-101b
Authors: Rathcke Alexander D , Buchhave Lars A , Mendonça João M , Sing David K , López-Morales Mercedes , Alam Munazza K , Henry Gregory W , Nikolov Nikolay K , García Muñoz A , Mikal-Evans Thomas , Wakeford Hannah R , Dos Santos Leonardo A , Rajpaul Vinesh Maguire 
Published: April 2023

ABSTRACT
We present an optical transmission spectrum of the hot Jupiter WASP-101b. We observed three primary transits with Hubble Space Telescope (HST)/Space Telescope Imaging Spectrograph, covering a wavelength range from 0.3 to 1 $\mu$m. The observations suffer from significant systematics that we model using Gaussian Processes. Kernel selection for the Gaussian Processes is performed in a data-driven approach through Bayesian model comparison. We find a flat and featureless transmission spectrum, corroborating a previous measurement obtained with HST/Wide-Field Camera 3 in the 1–1.7 $\mu$m range. The spectrum is consistent with high-altitude clouds located at less than 100 $\mu$bar. This cloud layer completely blocks our view into deeper parts of the atmosphere and makes WASP-101b the cloudiest gas giant observed so far. We compute a series of temperature-pressure profiles for WASP-101b and compare these to condensation curves for cloud particles, which match clouds composed of silicates. We also include 13 transits observed with Transiting Exoplanet Survey Satellite and use these to refine system parameters.
Cosmic ray-driven magnetohydrodynamic waves in magnetized self-gravitating dusty molecular clouds
Authors: Boro Pallab , Prajapati Ram Prasad 
Published: April 2023

ABSTRACT
The impact of galactic cosmic rays (CRs) in terms of CR pressure and parallel CR diffusion has been investigated on the low-frequency magnetohydrodynamic (MHD) waves and linear gravitational instability in the typical dusty plasma environment of molecular clouds (MCs). The dusty fluid model is formulated by combining the equations of the magnetized electrons/ions and dust particles, including the CR effects. The interactions between CR fluid and gravitating magnetized dusty plasma have been studied with the help of modified dispersion properties of the MHD waves and instabilities using the hydrodynamic fluid–fluid (CR–plasma) approach. CR diffusion affects the coupling of CR pressure-driven mode with dust-Alfvén MHD mode and causes damping in the MHD waves. It persists in its effect along the direction of the magnetic field and is diminished across the magnetic field. The phase-speed diagram shows that for super-Alfvénic wave, the slow mode becomes the intermediate Alfvén mode. The fundamental Jeans instability criterion remains unaffected due to CR effects, but in the absence of CR diffusion, the effects of dust-acoustic speed and CR pressure-driven wave speed are observed in the instability criterion. It is found that CR pressure stabilizes while CR diffusion destabilizes the growth rates of Jeans instability and significantly affects the gravitational collapse of dusty MCs. The charged dust grains play a dominant role in the sub-Alfvénic and super-Alfvénic MHD waves and the collapse of MCs, triggering gravitational instability. The consequences have been discussed to understand the gravitational instability in the dense photodissociation regions of dusty MCs.
Accretion of aerodynamically large pebbles
Authors: Huang Helong , Ormel Chris W 
Published: April 2023

ABSTRACT
Due to their aerodynamical coupling with gas, pebbles in protoplanetary discs can drift over large distances to support planet growth in the inner disc. In the past decade, this pebble accretion has been studied extensively for aerodynamically small pebbles (Stokes number St &lt; 1). However, accretion can also operate in the St &gt; 1 mode, e.g. when planetesimals collisionally fragment to smaller bodies or when the primordial gas disc disperses. This work aims to extend the study of pebble accretion to these aerodynamically loosely coupled particles. We integrate the pebble’s equation of motion, accounting for gas drag, stellar and planetary gravity, in the mid-plane of a laminar disc. The accretion probability (ϵ) is calculated as function of Stokes number, disc pressure gradient index, planet mass, and eccentricity. We find that for Stokes number above unity ϵ(St) first rises, due to lower drift and aided by a large atmospheric capture radius, until it reaches a plateau where the efficiency approaches 100 per cent. At high St, the plateau region terminates as particles become trapped in resonance. These results are well described by a semi-analytical ‘kick-and-drift’ model and we also provide fully analytical prescriptions for ϵ. We apply our model to the accretion of ${\sim }30\, \mu \mathrm{m}$ dust particles in a dispersing protoplanetary and secondary (CO-rich) debris disc. It shows that such physically small particles are mainly accreted as aerodynamically large Stokes number pebbles during the debris disc phase. Earth-mass planets may obtain ∼25 per cent of their heavy elements through this late accretion phase.
Off-centre supermassive black holes in bright central galaxies
Authors: Chu Aline , Boldrini Pierre , Silk Joe 
Published: April 2023

ABSTRACTSupermassive black holes (SMBHs) are believed to reside at the centre of massive galaxies such as brightest cluster galaxies (BCGs). However, as BCGs experienced numerous galaxy mergers throughout their history, the central BH can be significantly kicked from the central region by these dynamical encounters. By combining the TNG300 simulations and orbital integrations, we demonstrate that mergers with satellite galaxies on radial orbits are a main driver for such BH displacements in BCGs. BHs can get ejected to distances varying between a few parsecs to hundreds of kiloparsecs. Our results clearly establish that SMBH offsets are common in BCGs and more precisely a third of our BHs are off-centred at z = 0. This orbital offset can be sustained for up to at least 6 Gyr between z = 2 and z = 0 in half of our BCGs. Since the dense gas reservoirs are located in the central region of galaxies, we argue that the consequences of off-centre SMBHs in BCGs are to quench any BH growth and BH feedback.
Infrared spectroscopic confirmation of z ∼ 2 photometrically selected obscured quasars
Authors: Ishikawa Yuzo , Wang Ben , Zakamska Nadia L , Richards Gordon T , Hennawi Joseph F , Rivera Angelica B 
Published: April 2023

ABSTRACT
The census of obscured quasar populations is incomplete and remains a major unsolved problem, especially at higher redshifts, where we expect a greater density of galaxy formation and quasar activity. We present Gemini GNIRS near-infrared spectroscopy of 24 luminous obscured quasar candidates from the Sloan Digital Sky Survey’s Stripe 82 region. The targets were photometrically selected using a WISE/W4 selection technique that is optimized to identify IR-bright and heavily reddened/optically obscured targets at z &gt; 1. We detect emission lines of Hα, Hβ, and/or [O iii] in 23 sources allowing us to measure spectroscopic redshifts in the range 1 &lt; z &lt; 3 with bolometric luminosities spanning L = 1046.3–1047.3 erg s−1. We observe broad 103–104 km s−1 Balmer emissions with large Hα/Hβ ratios, and we directly observe a heavily reddened rest-frame optical continuum in several sources, suggesting high extinction (AV ∼ 7–20 mag). Our observations demonstrate that such optical/infrared photometric selection successfully recovers high-redshift obscured quasars. The successful identification of previously undetected red, obscured high-redshift quasar candidates suggests that there are more obscured quasars yet to be discovered.
Photometric and spectroscopic monitoring of YSOs in nearby star-forming regions – I. Eruptive YSOs
Authors: Contreras Peña Carlos , Herczeg Gregory J , Ashraf Mizna , Jose Jessy , Lee Ho-Gyu , Johnstone Doug , Lee Jeong-Eun , Zhou Xing-yu , Liu Hanpu , Yoon Sung-Yong 
Published: April 2023

ABSTRACTMid-infrared (mid-IR) variability in young stellar objects (YSOs) is driven by several physical mechanisms, which produce a variety of amplitudes and light-curve shapes. One of these mechanisms, variable disc accretion, is predicted by models of episodic accretion to drive secular variability, including in the mid-IR. Because the largest accretion bursts are rare, adding new objects to the YSO eruptive variable class aids our understanding of the episodic accretion phenomenon and its possible impact on stellar and planetary formation. A previous analysis of 6.5 yr of NeoWISE light curves (3–5 μm) of ∼7000 nearby YSOs found an increase in the fraction of variability and variability amplitude for objects at younger stages of evolution. To help interpret these light curves, we have obtained low- and high-resolution near-IR spectra of 78 objects from this sample of YSOs. In this work, we present the analysis of nine nearby YSOs (d&lt;1 kpc) that show the characteristics of known classes of eruptive variable YSOs. We find one FU Orionis (FUor)-like source, one EX Lupi type object, and six YSOs with mixed characteristics or V1647 Ori like objects. The varied characteristics observed in our sample are consistent with recent discoveries of eruptive YSOs. We discuss how a wide range in YSO outburst parameters (central mass, maximum accretion rate during outburst, evolutionary stage, and/or instability leading to the outburst) may play a significant role in the observed spectrophotometric properties of YSO outbursts.
Orbital precession in short-period hot Jupiter exoplanet systems
Authors: Alexander Murray E 
Published: April 2023

ABSTRACT
In several exoplanet systems the stellar rotation axis is not aligned with the normal to the orbital plane. For the class of ‘hot Jupiters’, a significant fraction of total angular momentum resides in the orbit. Orbit precessional motion has been observed in several such systems. We expect the tides raised by the orbiting exoplanet to induce normal mode oscillations in the host star, with the possibility of normal mode-orbit resonance. Gravity modes possess frequencies in the range of typical orbital Keplerian frequencies and their overtones. These resonances, confined to very narrow ranges of frequency space, would be highly improbable unless ‘resonance locking’ occurs, driven, for example, by structural and spin rate changes of the host star, operating on nuclear evolutionary time-scales. Resonance locking amplifies the amplitude of tidally driven oscillations, possibly by orders of magnitude, compared to the equilibrium tide displacements. We address the problem of precession and nutation in a system with a single exoplanet, with non-aligned spin and orbit axes, coupling the gravitational perturbations of normal mode distortions with orbital motion. Resonant modes are expected to have large amplitudes, contributing significantly to the gravitational perturbation already present due to rotational distortion of the star that gives rise to uniform orbital precession. The relative magnitude of rotational distortion and normal-mode perturbations is estimated. For Kepler-13Ab, estimates of their influence on transit time variations are given, and suggest they may be discernible with modern space telescope missions.
Efficient reconstruction of cell lineage trees for cell ancestry and cancer
Authors: Jang Yeongjun , Fasching Liana , Bae Taejeong , Tomasini Livia , Schreiner Jeremy , Szekely Anna , Fernandez Thomas V , Leckman James F , Vaccarino Flora M , Abyzov Alexej 
Published: April 2023

Abstract
Mosaic mutations can be used to track cell ancestries and reconstruct high-resolution lineage trees during cancer progression and during development, starting from the first cell divisions of the zygote. However, this approach requires sampling and analyzing the genomes of multiple cells, which can be redundant in lineage representation, limiting the scalability of the approach. We describe a strategy for cost- and time-efficient lineage reconstruction using clonal induced pluripotent stem cell lines from human skin fibroblasts. The approach leverages shallow sequencing coverage to assess the clonality of the lines, clusters redundant lines and sums their coverage to accurately discover mutations in the corresponding lineages. Only a fraction of lines needs to be sequenced to high coverage. We demonstrate the effectiveness of this approach for reconstructing lineage trees during development and in hematologic malignancies. We discuss and propose an optimal experimental design for reconstructing lineage trees.
Immunotherapy May Improve Tumor Sensitivity to Palliative Chemotherapy in Platinum Resistant Ovarian Cancer
Authors: Kinney Rachel E , Nair Suresh , Kim Christine H , Thomas M Bijoy , DelaTorre Martin 
Published: April 2023

AbstractOvarian cancer is the second most common gynecologic cancer in the US and ranks among the top 10 causes of female cancer-related deaths. Platinum-resistant disease carries a particularly poor prognosis and leaves patients with limited remaining therapeutic options. Patients with platinum-resistant disease have significantly lower response rates to additional chemotherapy, with estimates as low as 10%-25%. We hypothesize that in patients with platinum-resistant ovarian cancer, treatment with immunotherapy followed by cytotoxic chemotherapy with antiangiogenic therapy results in prolonged survival without compromising quality of life. Our experience of 3 patients with recurrent, metastatic platinum-resistant ovarian cancer treated with immunotherapy followed by anti-angiogenic treatment plus chemotherapy resulted in progression-free survival durations significantly above previously published averages. Further studies evaluating the role of immunotherapy followed by chemotherapy in combination with drugs targeting angiogenesis are needed and may provide a long-sought after breakthrough for advancing survival in platinum-resistant ovarian cancer.
Effects of Post-Anthesis High-Temperature Stress on Carbon Partitioning and Starch Biosynthesis in a Spring Wheat (Triticum aestivumL.) Adapted to Moderate Growth Temperatures
Authors: Harris P J , Burrell M M , Emes M J , Tetlow I J 
Published: April 2023

AbstractThis study investigates carbon partitioning in the developing endosperm of a European variety of spring wheat subjected to moderately elevated daytime temperatures (27°C/16°C d/night) from anthesis to grain maturity. Elevated daytime temperatures caused significant reductions in both fresh and dry weights and reduced the starch content of harvested grains compared to plants grown under a 20°C/16°C d/night regimen. Accelerated grain development caused by elevated temperatures was accounted for by representing plant development as thermal time (°C DPA). We examined the effects of high-temperature stress (HTS) on the uptake and partitioning of [U-14C]-sucrose supplied to isolated endosperms. HTS caused reduced sucrose uptake into developing endosperms from the second major grain-filling stage (approximately 260°C DPA) up to maturity. Enzymes involved in sucrose metabolism were unaffected by HTS, whereas key enzyme activities involved in endosperm starch deposition such as ADP-glucose pyrophosphorylase and soluble isoforms of starch synthase were sensitive to HTS throughout grain development. HTS caused a decrease in other major carbon sinks such as evolved CO2, ethanol-soluble material, cell walls and protein. Despite reductions in the labeling of carbon pools caused by HTS, the relative proportions of sucrose taken up by endosperm cells allocated to each cellular pool remain unchanged, except for evolved CO2, which increased under HTS and may reflect enhanced respiratory activity. The results of this study show that moderate temperature increases can cause significant yield reductions in some temperate wheat cultivars chiefly through three effects: reduced sucrose uptake by the endosperm, reduced starch synthesis and increased partitioning of carbon into evolved CO2.
Effect of duloxetine on opioid consumption and pain after total knee and hip arthroplasty: a systematic review and meta-analysis of randomized clinical trials
Authors: Azimi Amirali , Hooshmand Elham , Mafi Amir Ali , Tabatabaei Fatemeh-Sadat 
Published: April 2023

Abstract

Objectives
The purpose of this study was to investigate the analgesic effects of duloxetine, specifically on postoperative pain, opioid consumption, and related side effects following total hip or knee arthroplasty.

Methods
In this systematic review and meta-analysis, Medline, Cochrane, EMBASE, Scopus, and Web of Science were searched until November 2022 for studies which compared duloxetine with placebo when added to routine pain management protocols. Individual study risk of bias assessment was conducted based on Cochrane risk of bias tool 2. Random effect model meta-analysis was done on mean differences, to evaluate the outcomes.

Results
Nine randomized clinical trials (RCT) were included in the final analysis, totaling 806 patients. Duloxetine reduced opioid consumption (oral morphine milligram equivalents) on postoperative days (POD) 2 (mean difference (MD): −14.35, P  = .02), POD 3 (MD: −13.6, P &lt; .001), POD 7 (MD: −7.81, P &lt; .001), and POD 14 (MD: −12.72, P &lt; .001). Duloxetine decreased pain with activity on POD 1, 3, 7, 14, 90 (All P &lt; .05), and pain at rest on POD 2, 3, 7, 14, and 90 (all P &lt; .05). There was no significant difference in the prevalence of the side effects, except for increased risk of somnolence/drowsiness (risk ratio: 1.87, P = .007).

Conclusion
Current evidence shows low to moderate opioid sparing effects of perioperative duloxetine and a statistically but not clinically significant reduction in pain scores. Patients treated with duloxetine had an increased risk for somnolence and drowsiness.
Governing wickedness in megaprojects: discursive and institutional perspectives
Authors: Esposito Giovanni , Terlizzi Andrea 
Published: April 2023

AbstractMegaprojects are now as important as ever. As a response to the pandemic, the European Union has put forward the Next Generation EU policy, making available a 2021–2027 long-term budget of €1.8 trillion to fund projects with ecological and digital applications in the field of telecommunication, transportation, and energy infrastructures. Similarly, in the United States a $1.9 trillion Covid relief plan is on the way. Also, China has planned to expedite the rollout of 102 infrastructure megaprojects earmarked for the 2021–25 development plan. Despite their importance to policy-makers, megaprojects are often met with criticism and opposition by citizens, and often go off the rails—either with regard to budget or time, or both. This introductory article presents the aim and scope of the themed issue. It positions the problem areas beyond technical issues and connects them to the social and institutional environment within which megaprojects are planned and implemented. Moreover, the article makes the case for conceptualizing megaprojects as wicked policy fields. In doing so, we specify the three defining elements of megaprojects, namely, complexity, uncertainty, and conflict. The article argues that megaproject development cannot be seen as a rational, straightforward process. It is often a non-linear, conflictual process shaped by the collective action of different stakeholder groups (e.g., project managers, policy-makers, and citizens). Driven by divergent interests, sociotechnical imaginaries, as well as behavioral and discursive logics, groups of actors construct and mobilize narratives to influence final decision-making while interacting with the institutional context.