bluuebunny/crossref_metadata_2025_split huggingface dataset:
PARP-inhibitors Improve Progression-Free Survival in Breast Cancer Patients with Previous Platinum Exposure – A Systematic Review and Meta-Analysis
Authors: Pessoa Beatriz , Brandao Gabriela , Silva Caroliny Da , Gatof Emily , Yadav Siddhartha , Ernst Brenda , Mina Lida , Couch Fergus , Wulf Gerburg , Tung Nadine , Batalini Felipe , Marinho Alice 
Published: June 2023

Abstract
Importance:
The poly-adenosine diphosphate–ribose polymerase (PARP) enzymes are important for DNA single-strand break repair and PARP inhibitors (PARPi) cause an accumulation of unresolved DNA damage in tumors with BRCA1/2 mutations, resulting in cell death. However, because platinum salts also ultimately cause double-strand DNA breaks and may have overlapping mechanisms of resistance with PARPi, the efficacy of PARPi in patients with prior platinum therapy is unknown.
Objective
We sought to evaluate the efficacy of PARPi in patients with BRCA1/2-related breast cancer and previous platinum exposure.
Data Sources:
PubMed, Embase, and Cochrane Central Register of Controlled Trials databases were searched for papers up to June 26, 2022.
Study Selection:
We performed a systematic review and meta-analysis of studies that evaluated the efficacy of PARPi in patients with advanced or metastatic breast cancer and germline BRCA1/2 mutations. Two independent investigators identified double-blind, randomized controlled trials (RCTs) that included the subgroup of previous exposure to platinum.
Data Extraction and Synthesis:
Data extraction from published reports and quality assessment were performed under Cochrane recommendations. The software Review Manager 5.3 was selected for conducting the statistical analyses.
Main Outcome(s) and Measure(s):
The primary endpoint of interest was progression-free survival (PFS). Hazard ratios (HRs) with a 95% confidence interval (CI) were pooled, and a p-value of < 0.05 was considered statistically significant.
Results
From 2,069 database results (487 on PubMed; 1,376 on Embase; and 206 on Cochrane), 42 studies were fully reviewed, and 4 RCTs (total of 249 patients) were included in the final investigation. The PARPi included were Olaparib, Talazoparib, Niraparib, and Veliparib. Pooled analysis showed that PARPi improved PFS in breast cancer patients with prior treatment with platinum-based therapy compared to the control group [HR = 0.72; 95% CI, 0.53–0.97; p = 0.03]. For comparison, the population without previous platinum exposure had a similar magnitude of benefit from PARPi [HR = 0.68; 95% CI, 0.52–0.89; p = 0.005].
Conclusions and Relevance:
Despite the concerns about cross-resistance between PARPi and platinum agents, patients with advanced breast cancer and previous exposure to platinum therapy have a longer PFS with PARPi when compared to standard chemotherapy.
Endothelial progenitor cell-derived exosomal miRNA-31 alleviates septic peritonitis by inhibiting E-selectin expression: an investigation on the mechanism of action
Authors: Liu Shaoguang , Zhang Shaotong , Wang Bo , Zhou Wence 
Published: June 2023

Abstract
Purpose: The critical role played by miRNAs in sepsis-induced acute peritonitis has been repeatedly validated. This research focuses on elucidating the influence of endothelial progenitor cells (EPC)-derived exosomal miRNA-31 (exo-miR-31) on septic peritonitis (SP) and the role of E-selectin (SELE) in this process.
Methods: Differences in serum miRNA-31 and soluble SELE (sSELE) expression between SP cases and healthy controls (HCs) were identified. Additionally, we built a mouse colon ascendens stent peritonitis (CASP) model and an in vitro sepsis model via lipopolysaccharide (LPS) stimulation of mouse venous endothelial cells to verify the specific mechanism of EPC-derived exo-miR-31 on SP in vitro and in vivo.
Results: As indicated by enzyme-linked immunosorbent assay (ELISA) and quantitative real-time polymerase chain reaction (qRT-PCR) results, SP cases showed markedly reduced serum miR-31 levels and evidently elevated sSELE expression than HCs, with the expression of both genes altered more significantly as the condition worsened. Correlation analysis suggested a strong association between serum miRNA-31 and sSELE levels and sepsis severity. miR-31 in the peritoneal lavage fluid (PLF) of CASP model mice was down-regulated, while sSELE and inflammatory factors (IFs) TNF-α, IL-6 and IL-10 were notably increased. Gimsa staining revealed the massive recruitment and aggregation of nucleated cells in the abdominal cavity of CASP mice, and HE staining showed extensive neutrophilic infiltration in lung, liver and colon tissues, with obvious inflammatory tissue destruction. Besides, large numbers of bacteria were detected in the peripheral blood and PLF of CASP mice, with many CASP mice dying within 48 hours, as indicated by the bacterial smears and culture tests. EPC-derived exo-miR-31 was effective in elevating PLF miR-31 expression in CASP mice while suppressing sSELE, TNF-α, IL-6 and IL-10 levels. In EPCs-ExosmiR-31 group, significant reductions in nucleated cell counts in the mouse PLF, neutrophil infiltration in lung, liver and colon tissues, and peripheral blood and PLF bacterial loads were observed, as well as an obvious extension in survival. In addition, in vitro experimental results of cell sepsis showed that miR-31 could obviously block the inhibitory effect of LPS stimulation on the proliferation level of mouse venous endothelial cells and inhibit the level of apoptosis. SELE, Caspase-3 and Bax protein levels were markedly lower in LPS+miR-31 group as compared to LPS and LPS-miR-NC groups, while Bcl-2 was increased (P<0.05). Dual luciferase reporter gene assay identified the role of miR-31 as the direct target of SELE.
Conclusions: EPC-derived exo-miR-31 can effectively alleviate SP, possibly through targeted inhibition of SELE, providing a potential new direction for future prevention and treatment of SP.
Improved KW entropy: a complexity measurement technique for time-series and its application in feature extraction of quay crane gearbox
Authors: Gu Chunxia , Bi Juan , Wang Bing 
Published: June 2023

Abstract
The working environment of the quay crane is harsh and special. As an important transmission equipment of hoisting mechanism, health condition of gearbox is very important for reliable operation. In order to extract degradation features from complex vibration monitoring signals, an improved KW symbol entropy feature extraction technique is proposed. Considering the unity of symbol standard, the method takes the root mean square of the normal condition signal as the symbol standard and combines the symbol coefficient to construct a unified symbol scale. At the same time, symbols number variable is introduced to expand symbols set and improve the information expressing ability. On this basis, combining with information entropy theory, complexity of symbol sequence in symbol sequence and symbol distribution is calculated respectively, and two features named improved symbol sequence entropy (IKSE) and improved symbol distribution entropy (IKDE) are obtained. The Logistic chaotic sequence and the lifetime signal of the hoisting gearbox are used for analysis respectively. The result show that the proposed features are able to characterize the complexity of nonlinear time series, so as to describe the whole process of the performance degradation of the hoisting gearbox sensitively. The parameters have little influence and the technique have a good stability.
A controlled clinical study on efficacy and safety of periocular triamcinolone acetonide injection for treating ocular myasthenia gravis
Authors: Shi Minghua , Lu Zhuneng , Qin Aijiao , Cheng Jing , Chen Simin , Xing Yiqiao 
Published: June 2023

Abstract
OBJECTIVE
To evaluate the efficacy and safety of peribulbar triamcinolone acetonide injection for treating ocular myasthenia gravis (OMG), with a comparison of traditional oral drug therapy.
METHODS
A total of 22 patients with OMG who received periocular triamcinolone acetonide injection (initially 20mg weekly, then once per month later if symptoms were improved) from July 2019 to July 2022 were evaluated by a comparison of symptom degree before and after treatment. Adverse reactions were also monitored during the period of treatment. The period of follow-up was more than 6 months. Additionally, a comparison of the treatment efficacy between this periocular injection and traditional oral administration was performed in OMG patients.
RESULTS
After 4 weeks of treatment, the degree of ptosis in OMG patients decreased to -3.00 ± 0.69, compared to the value (-0.86 ± 1.32) before treatment. The degree of ophthalmoplegia also decreased from 3.12 ± 0.72 to 0.86 ± 0.88 (P<0.001) after treatment. The achievement rates of minimal manifestations status (MMS)for ptosis and ophthalmoplegia after 4 week-treatment were 86.3% and 75%, respectively, while they were 50% and 30% in patients with traditional oral administration. There was statistically significant difference only in MMS (rather than symptom relief rate and generalization conversion rate)between two groups. Noserious complications (except for intraorbital hematoma) were found in OMG patients during the treatment period.
CONCLUSION
Repeated peribulbar injection of triamcinolone acetonide can effectively alleviate the initial symptoms of OMG patients. However, the evaluation of its long-term efficacy is still needed.
This study has been clinically registered by Chinese Clinical Trial Registry (ChiCTR), first trial registration date:05/07/2019, registration number: ChiCTR1900024285.
Eosinophilic Meningitis After Bovine Graft Duraplasty:a Case Report and Literature Review
Authors: Xu Yuxin , Zha Jian , Che Yuanyuna , Yi Zhaoshi , Wang Ruiyan , Yu Xiongying , Zhong Jianmin , Chen Yong 
Published: June 2023

Abstract
Background
Eosinophilic meningitis after bovine graft duraplastyis is extremely rare, and cerebrospinal fluid cytology is of great significance for the diagnosis of this disease.Conventional anti-infective treatment was ineffective in most patients, and symptoms were relieved after the use of steroids or removal of the artificial dura.
Case presentation:
We report the first case of eosinophilic meningitis after bovine graft duraplastyis in China.A 7-year-old girl underwent cerebellar tumor resection and duraplasty in our hospital, using bovine dura mater.After 13 days, she developed fever, poor mental state, and cervical resistance. The cerebrospinal fluid(CSF) examination showed increased white blood cells, low glucose, and high protein. The Cerebrospinal fluid cytology revealed an eosinophil-reactive type. Metagenomic next-generation sequencing of cerebrospinal fluid was negative and no tumor cells were found in CSF. Vancomycin and meropenem were ineffective in treatment, but symptoms disappeared after dexamethasone administration.Cerebrospinal fluid improved after immunotherapy.Symptoms did not recur after discontinuation of antibiotics.
Conclusion
Eosinophilic meningitis after bovine graft duraplastyis is extremely rare, and cerebrospinal fluid cytology is of great significance for the diagnosis of this disease.Conventional anti-infective treatment was ineffective in most patients, and symptoms were relieved after the use of steroids or removal of the artificial dura
Trace elements and arsenic speciation in Paracentrotus lividus from North-West Mediterranean Sea
Authors: LEUFROY Axelle , Bouchoucha Marc , Rivière Gilles , Guérin Thierry , Jitaru Petru 
Published: June 2023

Abstract

Levels of 14 trace elements (Al, Ti, V, Cr, Mn, Co, Ni, Zn, As, Se, Cd, Sn, Hg and Pb) and 5 arsenic species (arsenite/As(III), arsenate/As(V), monomethylarsonic acid/MA, dimethylarsinic acid/DMA and arsenobetaine/AsB) were assessed in the gonads of sea urchin samples (Paracentrotus lividus) from North-West Mediterranean Sea (French coast). The samples were collected from 13 sites characterized by different types and levels of chemical contamination. Trace elements levels were measured by inductively coupled plasma-mass spectrometry (ICP-MS) following microwave (acid) digestion in a closed system, whereas As speciation analysis was carried out by ion-exchange liquid chromatography coupled with ICP-MS after microwave assisted extraction. High levels of trace elements were found in sea urchins sampled from Corsica whereas the samples from Théoule were found to be the least contaminated. From all the analyzed urchin samples, none showed Cd, Hg or Pb concentrations above the regulatory levels set by the European Community (EC) No. 1881/2006 for seafood or bivalve mollusks. Regardin arsenic specation, AsB was confirmed to be the predominant species. Inorganic As (As(III) + As(V)) was mainly constituted by As(III), which was quantified in all samples. Methylated As forms (MA and DMA) represent 9 to 23% of the total As.
Correcting for the nonuniform boron distribution in a tumor for BNCT dose calculation
Authors: Teng Yi-Chiao , Chen Jiang , Zhong Wan-Bing , Liu Yuan-Hao 
Published: June 2023

Abstract
Most BNCT treatment planning systems perform dose calculations based on the assumption of a homogeneous BPA distribution in tumors, which leads to dose distortion due to the difference between the TNR range measured in PET images and the target delineation in CT images of the treatment plan. The heterogeneous BPA distribution in the target of the treatment plan can be obtained by image fusion. This study provides a way to quantify a heterogeneous BPA distribution based on PET images. Theoretically, the same mean TNR for dose calculation by homogeneous or heterogeneous BPA distribution should get almost the same mean dose. However, slightly different mean doses are found due to the partial volume effect for a small target volume. The wider the BPA distribution is, the higher the impact on the DVH distribution is. Dose distribution with homogeneous boron distribution may be overestimated in low boron uptake regions by wrong boron concentration and neutron flux depression. To accurately give the tumor prescription dose and achieve better tumor control, for low dose regions of the tumor should be considered more BNCT treatments or combined with other treatment modalities. The heterogeneous boron distribution must be taken into consideration to have an accurate dose estimation. Therefore, the way how medical physicists and clinicians process the TNR in GTV should be refined, and the method demonstrated in the work provides a good reference.
Beneficial effects of Angiotensin II Receptor Blockers on Mortality in Patients with COVID-19: a Retrospective Study from 2019 to 2020 in China
Authors: Xu Ke , He Wu , Yu Bo , Zhong Kaineng , Zhou Da , Wang Dao Wen 
Published: June 2023

Abstract
Background
COVID-19 pandemic has become a serious global public health problem. Although the use of angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II receptor type 1 blockers (ARBs) has been recommended in patients with COVID-19 and cardiovascular diseases (CVDs), according to the results of some small-sample retrospective analyses; however, there is still a lack of sufficient evidence to validate their efficacy. This multicenter retrospective study investigated whether ACEI/ARB administration was beneficial in patients with COVID-19 and CVDs.
Methods
A total of 11,231 patients with confirmed COVID-19 and CVDs, from 138 hospitals in Hubei Province, were included in this multicenter retrospective study. We compared the clinical characteristics and outcomes between the ARB and non-ARB groups and analyzed the risk factors for in-hospital death using univariate and multivariate Cox regression analyses and Kaplan–Meier curves.
Results
In the multivariate Cox regression model, after adjusting for age, gender, comorbidities, and in-hospital medications, ARB use was associated with lower all-cause mortality (adjusted HR, 0.53; 95% CI, 0.38–0.73; P < 0.001). After propensity score-matched analysis, the adjusted HR for the use of ARB associated with all-cause mortality was 0.62 (95% CI, 0.40–0.88; P = 0.02). Further subgroup analyses found that the adjusted HRs for the use of ARB associated with all-cause mortality were 0.52 (95% CI, 0.30–0.89; P = 0.016), 0.37 (95% CI, 0.21–0.64; P < 0.001), 0.42 (95% CI, 0.28–0.64; P < 0.001), and 0.55 (95% CI, 0.37–0.84; P = 0.005) in patients with heart failure, diabetes, and hypercholesterolemia, and severe COVID-19, respectively.
Conclusions
ARB administration was significantly associated with a lower risk of all-cause mortality in patients with COVID-19 and CVDs.
Trial registration
ClinicalTrials.gov NCT05615792.
Mindfulness-based Interventions to Support Wellbeing of Adults in Low Socio-economic Settings: A Realist Review
Authors: Foale Sarah , Botma Yvonne , Heyns Tanya 
Published: June 2023

Abstract
Background
Mindfulness as a modality involves training the innate human capacity for present-moment awareness with a view to cultivating a more harmonious and integrated life experience, especially in the face of hardship. Over the past four decades, the field of mindfulness has grown rapidly. Despite a substantial body of literature outlining the many benefits of mindfulness practice within a range of contexts and populations, the authors identified relatively few studies that address the adaptation, application and value of mindfulness-based interventions (MBIs) for adults within socio-economically challenged settings. To address this gap, we conducted a realist review of studies pertaining to MBIs within low socio-economic settings, culminating in a program theory which may be useful for the design of interventions going forward.
Methods
We selected realist review as the methodology as it is well suited to investigating the complex nature of social interventions. The value of realist review is that the exploration of the causal relationships between the mechanisms (M) within a specific context (C) towards particular outcomes (O) offers a deeper understanding of the intervention which may assist in more effective delivery going forward. The review follows the guidelines presented by the Realist and Meta-narrative Evidence Synthesis – Evolving Standards project
Results
Of the 112 documents identified, 13 articles met the inclusion criteria. Of these 13 studies, 11 were conducted in the United States, with little representation across the rest of the globe. The interventions described in these articles were varied. We identified mechanisms that offered beneficial outcomes for participants across a range of contexts, with indications of how interventions might be adapted towards greater accessibility, acceptability, and feasibility within communities.
Conclusion
By reviewing the various programs in their respective contexts, we developed a program theory for implementing socio-culturally adapted MBIs in low socio-economic settings. In the future, this program theory could be tested as a means to create a sense of wellbeing for people living in low socio-economic settings.
Longitudinal hippocampal subfield development associated with psychotic experiences in young people
Authors: Dooley Niamh , Roddy Darren , Carey Eleanor , Frodl Thomas , O'Hanlon Erik , Cannon Mary , O'Neill Aisling 
Published: June 2023

Abstract
Hippocampal volumetric reductions are observed across the psychosis spectrum, with interest in the localisation of these reductions within the hippocampal subfields increasing. Deficits of the CA1 subfield in particular have been implicated in the neuropathophysiology of psychotic disorders. Investigating the trajectory of these abnormalities in healthy adolescents repoting sub-threshold psychotic experiences (PE) can provide insight into the neural mechanisms underlying psychotic symptoms without the potentially confounding effects of a formal disorder, or antipsychotic medication. In this novel investigation, a sample of 211 young people aged 11–13 participated initially in the Adolescent Brain Development study. PE classification was determined by expert consensus at each timepoint. Participants underwent neuroimaging at 3 timepoints, over 6 years. 78 participants with at least one scan were included in the final sample; 33 who met criteria for a definite PE at least once across all the timepoints (PE group), and 45 controls. Data from bilateral subfields of interest (CA1, CA2/3, CA4/DG, presubiculum, and subiculum) were extracted for Linear Mixed Effects analyses. Right CA1 (p = 0.047), and right CA2/3 subfields (p = 0.015) displayed group by time interaction effects (subfield volume increased in the control group, and decreased in the PE group). Left presubiculum volumes were significantly reduced in the PE group compared to controls, regardless of time (p = 0.023). These findings provide novel evidence implicating hippocampal subfield abnormalities in the pathophysiology underlying psychotic experiences. The CA1 particularly may be a key indicator of vulnerability for psychosis symptomology.
Experience of severe and critical COVID-19 in interstitial lung disease patients
Authors: Pruneda Ana Karem S. , Barreto-Rodríguez José Omar , Selman Moises , Juárez-Hernández Fortunato , Buendía-Roldán Ivette 
Published: June 2023

Abstract
Background
Since the first case of severe COVID-19, its effect on patients with previous interstitial lung disease (ILD) has been uncertain. We aimed to describe baseline clinical characteristics in ILD patients hospitalized by several or critical COVID and compare mortality during hospitalization.
Methods
We studied patients with ILD plus COVID-19 and a control group, matched by age, 1:2 ratio of patients with COVID-19 without chronic lung disease. On admission, laboratory tests and sociodemographic variables we evaluated. We classified patients as severe or critically ill and compared baseline characteristics and mortality in each group. Additionally, we performed a sub-analysis of patients who died versus survivors.
Results
41 patients and 82 controls were analyzed. We found differences in the ILD group, women 65 versus 33% (p < 0.001); lower leukocytes (9 ± 6 versus 11 ± 7, p = 0.01), lower neutrophils (8 ± 5 vs 10 ± 6, p = 0.02). Also, higher mortality in the ILD plus critical COVID-19 group (63 vs. 33%, p = 0.007). Patients who died had higher BMI (28 ± 6 vs. 25 ± 4kg/m2, p = 0.05), less extended hospital stay (20 ± 17 vs. 36 ± 27 days, p = 0.01), and less days of evolution (9 ± 7 vs. 16 ± 16, p = 0.05).
Conclusions
We found higher mortality in patients with ILD plus critical COVID-19. Higher BMI and comorbidities were present in the non-survivors. The most common presented ILD was secondary to autoimmune diseases.
Numerical and Artificial Intelligence Techniques of Predicting Velocity Distribution in Compound Meandering Flows
Authors: Choudhary Jahnvi , Mohanta Abinash , Pradhan Arpan , Patra K. C. 
Published: June 2023

Abstract
Reliable investigation and simulation of flow characteristics are essential to resolve critical engineering problems such as channel design, energy losses and fluvial flows across river bends. This paper analyses the formulation of longitudinal velocity in experimental meandering channels of 1.37 and 1.06 sinuosity. RNG K-ɛ turbulence and Volume of Fluid (VOF) analysis are applied on a two-phase, 3DComputational Fluid Dynamics model of the sinous channels.. The numerical results are compared with their respective experimental data and validated with other laboratory and natural channels. The statical methods are made to observe that the numerical methods agree with the experimental values.