bluuebunny/crossref_metadata_2025_split huggingface dataset:
Designed Concave Octahedron Heterostructures Decode Distinct Metabolic Patterns of Epithelial Ovarian Tumors
Authors: Pei Congcong , Wang You , Ding Yajie , Li Rongxin , Shu Weikang , Zeng Yu , Yin Xia , Wan Jingjing 
Published: February 2023

AbstractEpithelial ovarian cancer (EOC) is a polyfactorial process associated with alterations in metabolic pathways. A high‐performance screening tool for EOC is in high demand to improve prognostic outcome but is still missing. Here, a concave octahedron Mn2O3/(Co,Mn)(Co,Mn)2O4 (MO/CMO) composite with a heterojunction, rough surface, hollow interior, and sharp corners is developed to record metabolic patterns of ovarian tumors by laser desorption/ionization mass spectrometry (LDI‐MS). The MO/CMO composites with multiple physical effects induce enhanced light absorption, preferred charge transfer, increased photothermal conversion, and selective trapping of small molecules. The MO/CMO shows ≈2–5‐fold signal enhancement compared to mono‐ or dual‐enhancement counterparts, and ≈10–48‐fold compared to the commercialized products. Subsequently, serum metabolic fingerprints of ovarian tumors are revealed by MO/CMO‐assisted LDI‐MS, achieving high reproducibility of direct serum detection without treatment. Furthermore, machine learning of the metabolic fingerprints distinguishes malignant ovarian tumors from benign controls with the area under the curve value of 0.987. Finally, seven metabolites associated with the progression of ovarian tumors are screened as potential biomarkers. The approach guides the future depiction of the state‐of‐the‐art matrix for intensive MS detection and accelerates the growth of nanomaterials‐based platforms toward precision diagnosis scenarios.
The Blue‐LED‐Sensitive Naphthoquinone‐Imidazolyl Derivatives as Type II Photoinitiators of Free Radical Photopolymerization
Authors: Borjigin Timur , Schmitt Michael , Giacoletto Nicolas , Rico Alexandre , Bidotti Hugo , Nechab Malek , Zhang Yijun , Graff Bernadette , Morlet‐Savary Fabrice , Xiao Pu , Dumur Frédéric , Lalevée Jacques 
Published: February 2023

AbstractIn this work, new naphthoquinone‐based photoinitiators are synthesized and applied for the first time in free radical photopolymerization. In the presence of acrylate monomers, these PIs display excellent photoinitiation capabilities under blue‐light LED@405 nm irradiation in a two‐component photoinitiating system in which the additive is a common iodonium salt (bis‐(4‐tert‐butylphenyl)iodonium hexafluorophosphate ‐ Iod) or a tertiary amine (ethyl 4‐dimethylaminobenzoate ‐ EDB). In controlled tests, the polymerization performance of dye4/Iod is equal to or better than that of common commercial Type II photoinitiators (2‐isopropylthioxanthone and benzophenone). Meanwhile, only a trace amount of photoinitiator is required (as low as 0.05%) to initiate the photopolymerization. It is worth noting that some of these compounds can also be used in one‐component photoinitiating system (monocomponent Type II behavior) and exhibit high photoinitiation ability. A series of complementary characterization analyses of two new naphthoquinone dyes (i.e. dye 1 and dye 4) with very similar chemical structures are carried out to investigate the relevant photochemical mechanism. Finally, 3D printing experiments are carried out by a simple and convenient Direct Laser Write (DLW) technique.
Stereospecific Synthesis of Allenes from β‐Ketosulfones
Authors: Wasilewska‐Rosa Alicja , Kisiel Kacper , Tkaczyk Antoni , Loska Rafał 
Published: February 2023

AbstractEnolates formed from 1‐phenyl‐5‐tetrazolyl β‐ketosulfones containing a tetrasubstituted α carbon centre undergo elimination to allenes with up to four substituents at the cumulene unit when treated with a weak base (phenolate) in DMSO at room temperature. The reaction is completely regioselective for allene vs diene formation in nearly all investigated cases and it proceeds with central‐to‐axial chirality transfer.magnified image
A Bio‐Mimetic Leaf Wetness Sensor from Replica Molding of Leaves
Authors: Nguyen Brian H. , Gilbert Gregory S. , Rolandi Marco 
Published: February 2023

AbstractPlant diseases cause hundreds of billions of dollars in global crop production each year. Many plant diseases develop when pathogens germinate and proliferate in the fertile environment of excess water on the leaf surfaces. Accurate measurement of how long a leaf stays wet is important to assess the risk of pathogen infestation and decide on appropriate management tactics. Commercial leaf wetness sensors estimate the duration of leaf wetness by monitoring the water accumulated on the sensor surface. However, this one‐size‐fits‐all sensor surface does not replicate the wetting behavior of specific leaves resulting in an imprecise measurement of leaf wetness. Here it is developed a leaf wetness sensor with replica molded surfaces that closely mimic the leaf of interest and provide a more accurate measurement of leaf wetness duration compared to commercial sensors. This simple approach allows for better prediction of leaf wetness duration for each plant species, affording individualized and more effective disease forecasting for the management of plant diseases.
A TfOH‐Catalyzed Multicomponent Reaction of Propargylic Alcohols, Sulfonamides and Aldehydes for the Synthesis of Acyclic α‐Arylidene β‐Aminoketones
Authors: Li Tiantian , Zhang Qinglin , Wang Zhihai , Yin Yan 
Published: February 2023

AbstractThis work demonstrates a TfOH‐catalyzed multicomponent reaction. Using propargylic alcohols, aldehydes and sulfonamides as the substrates, a wide variety of acyclic α‐arylidene β‐aminoketones were prepared in high yields. The reaction mechanism likely involved a sulfonyl imide intercepted Meyer‐Schuster rearrangement combined with 1,3‐aryl migration. The present transformations proceeded with a low catalyst loading and permitted a large number of substituents on all reactants. The superior atom economy, high yield and convenient operation of this reaction suggest that it may be a practical alternative for the construction of acyclic α‐arylidene β‐aminoketones.
Efficient Reverse Intersystem Crossing in Carbene‐Copper‐Amide TADF Emitters via an Intermediate Triplet State
Authors: Zobel J. Patrick , Wernbacher Anna M. , González Leticia 
Published: February 2023

AbstractThe mechanism behind reverse intersystem crossing (rISC) in metal‐based TADF emitters is still under debate. Thermal rISC necessitates small singlet/triplet energy gaps as realized in donor‐acceptor systems with charge‐transfer excited states. However, their associated spin‐orbit couplings are too small to account for effective rISC. Here, we report the first nonadiabatic dynamics simulation of the rISC process in a carbene‐copper(I)‐carbazolyl TADF emitter. Efficient rISC on a picosecond time scale is demonstrated for an initial triplet minimum geometry that exhibits a perpendicular orientation of the ligands. The dynamics involves an intermediate higher‐lying triplet state of metal‐to‐ligand charge transfer character (3MLCT), which enables large spin‐orbit couplings with the lowest singlet charge transfer state. The mechanism is completed in the S1state, where the complex can return to a co‐planar coordination geometry that presents high fluorescence efficiency.
Wide‐coverage and Efficient NIR Emission from Single‐component Nanophosphors through Shaping Multiple Metal‐halide Packages
Authors: Li Xin , Shen Xinyu , Lu Min , Wu Jinlei , Zhong Yuan , Wu Zhennan , Yu William W. , Gao Yanbo , Hu Junhua , Zhu Jinyang , Zhang Yu , Bai Xue 
Published: February 2023

AbstractWide‐coverage near infrared (NIR) phosphor‐converted LEDs possess promising potential for practical applications, but little is developed towards the efficient and wide‐coverage NIR phosphors. Here, we report the single‐component lanthanide (Ln3+) ions doped Cs2M(In0.95Sb0.05)Cl6 (M=alkali metal) nanocrystals (NCs), exhibiting emission from 850 to 1650 nm with high photoluminescence quantum yield of 20.3 %, which is accomplished by shaping the multiple metal halide octahedra of double perovskite via the simple alkali metal substitution. From Judd‐Ofelt theoretical calculation and spectroscopic investigations, the shaping of metal halide octahedra in Cs2M(In1−xSbx)Cl6 NCs can break the forbidden of f‐f transition of Ln3+, thus increasing their radiative transition rates and simultaneously boosting the energy transfer efficiency from host to Ln3+. Finally, the wide‐coverage NIR LEDs based on Sm3+, Nd3+, Er3+‐tridoped Cs2K0.5Rb0.5(In0.95Sb0.05)Cl6 NCs are fabricated and employed in the multiplex gas sensing and night‐vision application.
Enzymatic Electrosynthesis of Glycine from CO2 and NH3
Authors: Wu Ranran , Li Fei , Cui Xinyu , Li Zehua , Ma Chunling , Jiang Huifeng , Zhang Lingling , Zhang Yi‐Heng P. Job , Zhao Tongxin , Zhang Yanping , Li Yin , Chen Hui , Zhu Zhiguang 
Published: February 2023

AbstractEnzymatic electrosynthesis has gained more and more interest as an emerging green synthesis platform, particularly for the fixation of CO2. However, the simultaneous utilization of CO2 and a nitrogenous molecule for the enzymatic electrosynthesis of value‐added products has never been reported. In this study, we constructed an in vitro multienzymatic cascade based on the reductive glycine pathway and demonstrated an enzymatic electrocatalytic system that allowed the simultaneous conversion of CO2 and NH3 as the sole carbon and nitrogen sources to synthesize glycine. Through effective coupling and the optimization of electrochemical cofactor regeneration and the multienzymatic cascade reaction, 0.81 mM glycine was yielded with a highest reaction rate of 8.69 mg L−1 h−1 and faradaic efficiency of 96.8 %. These results imply a promising alternative for enzymatic CO2 electroreduction and expand its products to nitrogenous chemicals.
Exploration of ethylene glycol linked nitrofurantoin derivatives against Leishmania: Synthesis and in vitro activity
Authors: Ndlovu Keitumetsi , Kannigadu Christina , Aucamp Janine , van Rensburg Helena D. Janse , N'Da David D. 
Published: February 2023

AbstractLeishmaniasis is a neglected tropical disease that is caused by the Leishmania parasite. It is estimated that there are more than 350 million people at risk of infection annually. Current treatments that are in clinical use are expensive, have toxic side effects, and are facing parasitic resistance. Therefore, new drugs are urgently required. In the quest for new, safe, and cost‐effective drugs, a series of novel ethylene glycol derivatives of nitrofurantoin was synthesised and the in vitro antileishmanial efficacy of the compounds tested against Leishmania donovani and Leishmania major strains. Arylated ethylene glycol derivatives were found to be the most potent, with submicromolar activity up to 294‐fold greater than the parent compound nitrofurantoin. Analogues 2j and 2k had the best antipromastigote activities with submicromolar IC50 values against L. major IR‐173 and antimonial‐resistant L. donovani 9515 strains.
New benzimidazole‐oxadiazole derivatives: Synthesis, α‐glucosidase, α‐amylase activity, and molecular modeling studies as potential antidiabetic agents
Authors: Acar Çevik Ulviye , Celik Ismail , Paşayeva Leyla , Fatullayev Hanifa , Bostancı Hayrani E. , Özkay Yusuf , Kaplancıklı Zafer A. 
Published: February 2023

AbstractBenzimidazole‐1,3,4‐oxadiazole derivatives (5a–z) were synthesized and characterized with different spectroscopic techniques such as 1H NMR, 13C NMR, and HRMS. The synthesized analogs were examined against α‐glucosidase and α‐amylase enzymes to determine their antidiabetic potential. Compounds 5g and 5q showed the most activity with 35.04 ± 1.28 and 47.60 ± 2.16 µg/mL when compared with the reference drug acarbose (IC50 = 54.63 ± 1.95 µg/mL). Compounds 5g, 5o, 5s, and 5x were screened against the α‐amylase enzyme and were found to show excellent potential, with IC50 values ranging from 22.39 ± 1.40 to 32.07 ± 1.55 µg/mL, when compared with the standard acarbose (IC50 = 46.21 ± 1.49 µg/mL). The antioxidant activities of the effective compounds (5o, 5g, 5s, 5x, and 5q) were evaluated by TAS methods. A molecular docking research study was conducted to identify the active site and explain the functions of the active chemicals. To investigate the most likely binding mode of the substances 5g, 5o, 5q, 5s, and 5x, a molecular dynamics simulation was also carried out.
Novel Somatic UBA1 Variant in a Patient With VEXAS Syndrome
Authors: Stiburkova Blanka , Pavelcova Katerina , Belickova Monika , Magaziner Samuel J. , Collins Jason C. , Werner Achim , Beck David B. , Balajkova Veronika , Salek Cyril , Vostry Martin , Mann Herman , Vencovsky Jiri 
Published: February 2023

ObjectiveSomatic mutations in UBA1 have recently been causally linked to a severe adult‐onset inflammatory condition referred to as VEXAS (vacuoles, E1 enzyme, X‐linked, autoinflammatory, somatic) syndrome. Ubiquitin‐activating enzyme E1 (UBA‐1) is of fundamental importance to the modulation of ubiquitin homeostasis and to the majority of downstream ubiquitylation‐dependent cellular processes. Direct sequencing analysis of exon 3 containing the prevalent variants p.Met41Leu, p.Met41Val, and/or p.Met41Thr is usually used to confirm the disease‐associated mutations.MethodsWe studied the clinical, biochemical, and molecular genetic characteristics of a 59‐year‐old man with a 2‐year history of arthritis, fever, night sweats, nonspecific skin rash, lymphadenopathy, and myelodysplastic syndrome with multilineage dysplasia.ResultsThe mutational analysis revealed a previously undescribed sequence variant c.1430G>C in exon 14 (p.Gly477Ala) in the gene UBA1. In vitro enzymatic analyses showed that p.Gly477Ala led to both decreased E1 ubiquitin thioester formation and E2 enzyme charging.ConclusionWe report a case of a patient of European ancestry with clinical manifestations of VEXAS syndrome associated with a newly identified dysfunctional UBA‐1 enzyme variant. Due to the patient's insufficient response to various immunosuppressive treatments, allogeneic hematopoietic stem cell transplantation was performed, which resulted in significant improvement of clinical and laboratory manifestations of the disease.image
A Review of Polymer‐based Solid‐State Electrolytes for Lithium‐Metal Batteries: Structure, Kinetic, Interface Stability, and Application
Authors: Zhao Xiaoxue , Wang Chao , Liu Hong , Liang Yuhao , Fan Li‐Zhen 
Published: February 2023

AbstractSolid‐state polymer electrolytes (SPEs) for all‐solid‐state batteries (ASSBs) have received considerable attention owing to excellent processability, good flexibility, high safety levels, and superior thermal stability. However, the practical application of SPEs is currently restricted by their low ionic conductivity, narrow electrochemical oxidation window, and poor long‐term stability of lithium (Li) metal. These challenges are mainly related to the polymer molecular structures, the dynamic of the polymer electrolyte, and the polymer compound stability at the electrode‐electrolyte interface. In this review, we provide recent strategies and discuss strategies of interest for applications to high‐energy‐density ASSB, particularly the molecular design, ion‐transport dynamic mechanisms of solid polymer electrolytes, and organic‐inorganic composite. Based on recent work, perspectives on future research directions are discussed for developing solid polymer electrolytes.
Significantly raising tetracyanoquinodimethane electrode performance in zinc‐ion battery at low temperatures by eliminating impurities
Authors: Wang Shuchan , Deng Wenwen , Geng Zhiyuan , Li Peiyuan , Hu Naiqi , Zhu Limin , Sun Wei , Li Chang Ming 
Published: February 2023

AbstractApplications of organic compounds‐based electrodes in aqueous zinc‐ion batteries (AZIBs) at low temperatures are severely restricted by the freezing of aqueous electrolytes and the inferior dynamic behavior of organic electrodes below zero. Herein, tetracyanoquinodimethane (TCNQ) was purified by the sublimation method and used as a cathode in AZIBs to investigate electrochemical Zn storage performance in comparison with nonpurified TCNQ at a temperature range of 25°C to −40°C. Nuclear magnetic resonance and elemental analysis prove increased purity in purified TCNQ (p‐TCNQ), whereas scanning electron microscope and Brunner−Emmet−Teller data verify reduced particle size and increased surface area of p‐TCNQ. Kinetic analysis demonstrates that p‐TCNQ is a more surface‐controlled electrode process than TCNQ and offers much higher ionic diffusivity than the latter at various temperatures. Molecular dynamics simulation validates that the existence of impurity increases the absorption energy of TCNQ in a TCNQ//Zn system that is unfavorable to Zn migration. Comprehensive analysis, including ex situ X‐ray diffraction, Fourier transform infrared, Raman, and electron spin‐resonance spectroscopy characterization confirm the high reversibility of transformation between C≡N and −C═N groups in p‐TCNQ. This work provides a simple, environmentally friendly strategy to fabricate a high‐performance AZIB at low temperatures while offering fundamental chemistry insight into organic electrode performance, thus possessing universal significance.
Clinical protocol selection for alveolar ridge augmentation at sites exhibiting slight, moderate, and severe horizontal ridge deficiencies
Authors: Vargas Sarah M. , Johnson Thomas M. , Pfaff Aaron S. , Bumpers April P. , Wagner Jennah C. , Retrum Joseph K. , Colamarino Aaron N. , Bunting Megan E. , Wilson James P. , McDaniel Carsen R. , Herold Robert W. , Stancoven Brian W. , Lincicum Adam R. 
Published: February 2023

AbstractFocused clinical questionWhat factors identify the optimal bone augmentation techniques for managing slight, moderate, and severe horizontal alveolar ridge deficiency (ARD) at dental implant sites?SummaryHorizontal ARD is a concern at a high proportion of sites receiving dental implants, and clinicians have developed a variety of surgical procedures to address such defects. In a particular case, selection of the optimal treatment may depend predominantly on defect severity, location (anterior versus posterior), and configuration (contained versus noncontained). This report provides a framework for selecting an augmentation method when presented with a slight, moderate, or severe horizontal ARD at a site requiring dental implant placement.ConclusionMultiple treatment options are available for planned implant sites exhibiting horizontal ARD; severe posterior and slight anterior defects intuitively call for different approaches. Although rigid guidelines for selecting the optimal augmentation method do not exist, some techniques are poorly suited for esthetically demanding sites. A framework considering defect severity, location, and configuration may help guide clinical decisions on this topic.
Photocatalytic Proximity Labeling for Profiling the Subcellular Organization of Biomolecules
Authors: Fang Yuxin , Zou Peng 
Published: February 2023

AbstractInvestigating the subcellular organization of biomolecules is important for understanding their biological functions. Over the past decade, proximity‐dependent labeling methods have emerged as powerful tools for mapping biomolecules in their native context. These methods often capitalize on the in‐situ generation of highly reactive intermediates for covalently tagging biomolecules located within nanometers to sub‐micrometers of the source of labeling. Among these, photocatalytic proximity labeling methods achieve precise spatial and temporal control of labeling with visible light illumination. In this review, we summarize the mechanisms and applications of existing photocatalytic proximity labeling methods and discuss future opportunities for improving the method.
TAFRO syndrome was effectively treated with an inexpensive novel scheme: A case report
Authors: Meng Shan , Liu Hailing , Zhang Wanggang , He Aili , Sun Honghong , Zhang Ru , Chen Xiaoli , Chen Yinxia 
Published: February 2023

AbstractA man diagnosed as TAFRO syndrome was successfully responded to a novel immunosuppressive regimen containing methylprednisolone and mycophenolate mofetil. Blood cells firstly recovered, followed by the general situation and complete recover 1 month later, highlighting the danger of TAFRO syndrome and the importance of immunosuppressive agents in reversing pathological course.
Seizures in activating calcium‐sensing receptor antibodies positive autoimmune hypoparathyroidism and preponderance of steroids therapy: A case report
Authors: Khan Qaisar Ali , Shahi Ameena , Shahi Alishba , Baqi Abdul , Tango Tamara , Verma Ravina , Hamid Asrah Abdul , Saravanan Priyadharshini , Alam Mazhar , Shinwari Ismail Khan , Ul Ain Hoor 
Published: February 2023

AbstractA 55‐year‐old female patient presented with generalized tonic–clonic seizures. Laboratory evaluation revealed low calcium (4.9 mg/dl), low PTH (0.9 pg/ml), and positive activating CaSR antibodies. The condition was diagnosed as autoimmune hypoparathyroidism. Calcium and vitamin D supplements did not correct the patient's hypocalcemia. The addition of prednisone to vitamin supplements showed a better response and corrected the hypocalcemia. The patient remained in seizure‐free for one year.
Sarcoidosis and its oral manifestations: A case report study
Authors: Shahabinejad Mehdi , Delavarian Zahra , Zamani Toktam , Fallah Toosi Fatemeh 
Published: February 2023

AbstractA patient was referred to the oral medicine department with redness and swelling of the lips and cheek, and an intra‐oral lesion. Biopsy and laboratory investigations suggested a diagnosis of sarcoidosis. In this study we discuss oral findings associated with sarcoidosis.
A case of post‐COVID‐19 myalgic encephalomyelitis/chronic fatigue syndrome characterized by post‐exertional malaise and low serum acylcarnitine level
Authors: Jinushi Ryuhei , Nishiguchi Sho , Masuda Sakue , Sasaki Akiko , Koizumi Kazuya , Ryozawa Shomei 
Published: February 2023

AbstractCOVID‐19 afflicts patients with acute symptoms and longer term sequelae. One of the sequelae is myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), which is often difficult to diagnose, having no established tests. In this article, we synthesize information from literature reviews on patients with ME/CFS that developed after recovery from COVID‐19.
Palliative radiation therapy for bleeding from gastric cancer: A case series of seven patients
Authors: Ota Norichika , Adachi Akiko , Oike Takahiro , Hisatake Yuta , Higashizawa Toshihiko , Teramoto Ken , Okamura Yukishige , Ohno Tatsuya 
Published: February 2023

AbstractThe hemostatic effect of palliative radiation therapy (RT) for unresectable gastric cancer is unclear. We performed palliative RT (20 Gy in 5 fractions or 30 Gy in 10 fractions) in 7 consecutive patients with bleeding. The number of blood transfusions decreased significantly post‐RT, supporting the hemostatic effect of palliative RT.
Coinage Metal Bis(amidinate) Complexes as Building Blocks for Self‐Assembled One‐Dimensional Coordination Polymers
Authors: Uhlmann Cedric , Feuerstein Thomas J. , Gamer Michael T. , Roesky Peter W. 
Published: February 2023

AbstractThe pyridyl functionalized amidinate [{PyC≡CC(NDipp)2}Li(thf)2]n was used to synthesize a series of bis‐amidinate complexes [{PyC≡CC(NDipp)2}2M2] (M=Cu, Ag, Au) with fully supported metallophilic interactions. These metalloligands were then used as building blocks for the synthesis of one‐dimensional heterobimetallic coordination polymers using Zn(hfac)2 (hfac=hexaflouroacetylacetonate) for self‐assembly. Interestingly, the three coordination polymers [{PyC≡CC(NDipp)2}2M2][Zn(hfac)2] (M=Cu, Ag, Au), exhibit a zig zag shape in the solid state. To achieve linear coordination geometry other connectors such as M’(acac) (M’=Ni, Co) (acac=acetylacetonate) were investigated. The thus obtained compounds [{PyC≡CC(NDipp)2}2Cu2][M’(acac)2] (M’=Ni, Co) are indeed linear heterobimetallic coordination polymers featuring a metalloligand backbone with fully supported metallophilic interactions.