bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of different doses of different biostimulants on the yield of oily sunflower
Authors: Yuldasheva Z F , Karabayeva D J 
Published: March 2023

Abstract
Biologically active substances (BASs), including plant phytohormones-regulators of plant growth and development, are becoming increasingly important in agriculture activities. Their use allows to better realize the genetic potential of crops, increase the resistance of plants to stress factors of biotic and abiotic nature, and as a result increase yields and improve quality. In this research, it was aimed at researching effect of different doses of different biostimulants on the yield of oily sunflower. In the research experiment, “Methods of field experiments” developed by B. Dospekhov was used. According to the results, it was found that microbio-fertilizers, biostimulants, immunostimulants had positive effect on the growth, development and seed formation of the local Dilbar variety of sunflower, the weight and yield of 1000 seeds. When biodux biostimulator was applied to the 1.0 ml/t seed variant, the height of sunflower stem was 28.5 cm higher than the control and 7.1 cm higher than the “UzGUMI” standard. Furthermore, when the MERS microbiota fertilizer was used in the 2.0 ml/ton variant, the stem height was 25.5 cm higher, and it was 4.1 cm higher than the UzGUMI standard. The 1000 seed weight was found to be heavier than the other biostimulants used in the experiment, especially in the variant using MERS microbiota.
Sustainable coastal management in supporting blue economy: an Indonesian experience
Authors: Safitri D P , Hakim A , Muluk M R K , Putra F 
Published: March 2023

Abstract
The coastal regions had a great ecosystem and potential for the sustainability of life. At the same time, growing human and environmental pressures in coastal areas significantly impact coastal systems. Various problems arise in the development and utilisation of the coastal regions. The issues have prompted the importance of studying coastal area management policies. Specifically, legal uncertainty in the management of utilisation has initiated the formulation of the RZWP3K policy. This study uses stakeholder analysis to map the actors involved and their influence on coastal area management policies. This study was conducted using a qualitative method and stakeholder analysis to explore and classify the actors shaping coastal area management policies. The stakeholder analysis method classified constituents into important actors, contextual fixers, users, and audiences using variables of interest and impact. Developing policies for coastal management is hampered by the conflicting agendas of many parties and their multiple goals and worries. This study recommends that the government maintain stakeholders by keeping them informed, actively groomed, monitored and managed, or satisfied. This paper contributes to conceptual stakeholder analysis literature to analyse coastal area management policies.
MicroRNAs in septic acute kidney injury
Authors: Wang Bo , Xu Jun , Fu Ping , Ma Liang 
Published: March 2023

AbstractSepsis is a potentially fatal complication of burns and trauma that can cause acute kidney injury (AKI) with substantial morbidity and mortality, but this disease is poorly understood. Despite medical advances, effective therapeutic regimens for septic AKI remain uncommon. MicroRNAs (miRNAs) are endogenous non-coding RNAs that influence the translation of target messenger RNAs in a variety of biological processes. Emerging evidence has shown that miRNAs are intimately associated with septic AKI. The goal of this review was to summarize recent advances in the profound understanding of the functional role of miRNAs in septic AKI, as well as to provide new insights into miRNAs as feasible biomarkers and therapeutic targets for septic AKI.
Experimental investigation on flow condensation pressure drop of R134a in microfin tube at high mass flux
Authors: Qiu Fuqiang , Xu Taoping , He Dugui , Du Juanli 
Published: March 2023

Abstract
To clarify the influencing mechanisms of the experimental condition and the tube structure on the pressure drop of heat transfer fluid, the two-phase flow condensation pressure drop of R134a inside the microfin tube was experimentally studied at high mass flux, which is different from other conventional researches. The experimental result shows the pressure drop is proportional to mass flux and fin helical angle, and is inversely proportional to condensation temperature and coolant Reynolds number. Moreover, the experimental data of pressure drop was compared with the predicted value of some existing correlations for the microfin tube. It can be found that the correlations of Cavallini et al., Han et al. and Haraguchi et al. show a good prediction effect with mean relative deviation (MRD) of 13.89, 16.08 and −2.19%, respectively. The correlations of Pierre/0.053, Kedzierski et al. and Choi et al. all underestimate most of the experimental data of the pressure drop inside the tube, and their prediction deviations are &gt;10%. That is, the application effect of the separated flow model is better than that of the homogeneous flow model. Finally, the Kedzierski et al. correlation was improved to realize a high-precision prediction of the fluid flow mechanism inside the tube. Because the prediction deviation of the improved correlation between the experimental value and the predicted value was greatly reduced, its prediction deviation is &lt;10% for R134a and R410A; therefore, it can be said the improved correlation has a good predictive result for the pressure drop.
Why Aquinas Should Have Held That One May Intentionally Tell A Falsehood to an Unjust Aggressor
Authors: Vincelette Alan 
Published: March 2023

Abstract
Aquinas argued that one may never intentionally tell an outright falsehood, that is to say, lie, even if one is doing so to help save another person’s life. Yet his position here is very different from how he treats the nature of other moral norms such as stealing, promise-keeping, and murder. For the latter Aquinas defends exceptionless moral norms, but by carefully defining what constitutes stealing, promise-keeping, and murder, allows a limited number of disassociating circumstances wherein morally relevant situations (such as a grave necessity or the presence of an unjust aggressor) take actions out of the categories of stealing or murder strictly speaking. Aquinas furthermore allows divine disassociations from the moral law in cases of murder, stealing, and even adultery, which remove certain acts from being included in prohibited categories because of divine decree, but he does not do so for lying. As a consequence, Aquinas has to resort to various elaborations as to how what seems to be a telling of a falsehood by an Old Testament figure is not really so. I will argue here that there are reasons to think Aquinas was inconsistent in his approach, and that given his philosophical presuppositions he could have and indeed should have held that it is licit to intentionally tell a falsehood to an unjust aggressor, and that this would have rendered his thought more coherent as a whole.
Serum Ribonucleotide Reductase Subunit M2 in Patients with Chronic Liver Diseases and Hepatocellular Carcinoma
Authors: Jin Xuehang , Yu Wei , Wang Ange , Qiu Yunqing 
Published: March 2023

Abstract

Background
Ribonucleotide reductase subunit M2 (RRM2) plays a key role in cell and hepatitis B virus (HBV) replication. Nevertheless, its clinical implications for managing liver diseases have been inadequately studied.

Methods
A total of 412 participants were enrolled, including 60 healthy control individuals, 55 patients with chronic hepatitis B (CHB), 173 patients with cirrhosis, and 124 patients with hepatocellular carcinoma (HCC). Serum RRM2 was measured via ELISA.

Results
The level of serum RRM2 in patients with CHB, cirrhosis, and HCC was higher than that in healthy controls (P &lt; .05). A large difference in serum RRM2 was found between HBV-related and non–HBV-related patients in the cirrhosis group (P &lt; .001), compared with the difference between HBV-related HCC and non–HBV-related HCC (P = .86). In the HBV-related cirrhosis group, the serum RRM2 level showed significant positive correlations with HBV DNA, hepatitis B surface antigen, hepatitis B e antigen, Child-Pugh scores, and MELD scores and played a strong role in diagnosing HBV-related cirrhosis in CHB, compared with fibrosis-4 score and aspartate aminotransferase–to-platelet ratio index.

Conclusions
Serum RRM2 is a reliable biomarker for accurate HBV-related cirrhosis diagnosis and evaluation. Also, serum RRM2 could reflect the expression state of HBV replication in patients with HBV-related cirrhosis.
Tame and full strict-Π11 reflection: A proof-theoretic approach
Authors: Jäger Gerhard 
Published: March 2023

Abstract
Strict-$\varPi ^{1}_{1}$ reflection is an important principle that is discussed in detail, e.g. in Barwise [ 2]. Whereas Barwise puts his focus on the importance of strict-$\varPi ^{1}_{1}$ formulas for generalized recursion theory and definability theory, we choose a proof-theoretic approach.
14-3-3 proteins facilitate the activation of MAP kinase cascades by upstream immunity-related kinases
Authors: Dong Xiaojing , Feng Feng , Li Yangjun , Li Lin , Chen She , Zhou Jian-Min 
Published: March 2023

Abstract
Activation of mitogen-activated protein kinase (MAP kinase) cascades is essential for plant immunity. Upon activation by surface-localized immune receptors, receptor-like cytoplasmic kinases (RLCKs) in the cytoplasm phosphorylate MAP kinase kinase kinases (MAPKKKs) to initiate MAP kinase activation. Surprisingly, we found that both the phosphorylation of Arabidopsis (Arabidopsis thaliana) MAPKKKs and the subsequent activation of MAP kinase cascades require the λ and κ isoforms of 14-3-3 proteins, which directly interact with multiple RLCKs and MAPKKKs. The N- and C-termini of MAPKKK5 interact intramolecularly to inhibit the access to the C terminus by RLCKs, whereas the 14-3-3 proteins relieve this inhibition and facilitate the interaction of RLCKs with the C-terminus of MAPKKK5. This enables the phosphorylation of MAPKK5 at Ser599 and Ser682, thus promoting MAP kinase activation and enhancing plant disease resistance. Our study reveals a role of 14-3-3 proteins as scaffolds and activators in the regulation of the RLCK-MAPKKK5 module and provides insight into the mechanism of plant immune signaling.
ABCC4 is a PGE2 efflux transporter in the ovarian follicle: A mediator of ovulation and a potential non‐hormonal contraceptive target
Authors: Yerushalmi Gil M. , Shuraki Batel , Yung Yuval , Maman Ettie , Baum Micha , Hennebold Jon D. , Adashi Eli Y. , Hourvitz Ariel 
Published: March 2023

AbstractThe role of prostaglandins (PGs) in the ovulatory process is known. However, the role of the ATP binding cassette subfamily C member 4 (ABCC4), transmembrane PG carrier protein, in ovulation remains unknown. We report herein that ABCC4 expression is significantly upregulated in preovulatory human granulosa cells (GCs). We found that PGE2 efflux in cultured human GCs is mediated by ABCC4 thus regulating its extracellular concentration. The ABCC4 inhibitor probenecid demonstrated effective blocking of ovulation and affects key ovulatory genes in female mice in vivo. We postulate that the reduction in PGE2 efflux caused by the inhibition of ABCC4 activity in GCs decreases the extracellular concentration of PGE2 and its ovulatory effect. Treatment of female mice with low dose of probenecid as well as with the PTGS inhibitor indomethacin or Meloxicam synergistically blocks ovulation. These results support the hypothesis that ABCC4 has an important role in ovulation and might be a potential target for non‐hormonal contraception, especially in combination with PGE2 synthesis inhibitors. These findings may fill the gap in understanding the role of ABCC4 in PGE2 signaling, enhance the understanding of ovulatory disorders, and facilitate the treatment and control of fertility.
Deletion of the tyrosine phosphatase Shp2 in cervical cancer cells promotes reprogramming of glutamine metabolism
Authors: Gao Xuehui , Kang Jie , Li Xiangke , Chen Chuan , Luo Duqiang 
Published: March 2023

AbstractShp2 is a nonreceptor protein tyrosine phosphatase that is overexpressed in cervical cancer. However, the role of Shp2 in the regulation of cervical cancer metabolism and tumorigenesis is unclear. EGFR signaling pathways are commonly dysregulated in cervical cancer. We showed that Shp2 knockout in cervical cancer cells decreased EGFR expression and downregulated downstream RAS–ERK activation. Although AKT was activated in Shp2 knockout cells, inhibition of AKT activation could not make cells more sensitive to death. Shp2 depletion inhibited cervical cancer cell proliferation and reduced tumor growth in a xenograft mouse model. 1H NMR spectroscopic analysis showed that glutamine, glutamate, succinate, creatine, glutathione, and UDP‐GlcNAc were significantly changed in Shp2 knockout cells. The intracellular glutamine level was higher in Shp2 knockout cells than in control cells. Further analysis demonstrated that Shp2 knockout promoted glutaminolysis and glutathione production by up‐regulating the glutamine metabolism‐related genes such as glutaminase (GLS). However, inhibition of GLS did not always make cells sensitive to death, which was dependent on glucose concentration. The level of oxidative phosphorylation was significantly increased, accompanied by an increased generation of reactive oxygen species in Shp2 knockout cells. Shp2 deficiency increased c‐Myc and c‐Jun expression, which may be related to the upregulation of glutamine metabolism. These findings suggested that Shp2 regulates cervical cancer proliferation, glutamine metabolism, and tumorigenicity.
Two-Surgeon Multidisciplinary Approach to Pediatric Cervical Spinal Fusion: A Single-Institution Series and Review of the Literature
Authors: Lynch Benjamin T. , Montgomery Blake K. , Verhofste Bram P. , Proctor Mark R. , Hedequist Daniel J. 
Published: March 2023

Background:
A collaborative 2-surgeon approach is becoming increasingly popular in surgery but is not widely used for pediatric cervical spine fusions. The goal of this study is to present a large single-institution experience with pediatric cervical spinal fusion using a multidisciplinary 2-surgeon team, including a neurosurgeon and an orthopedic surgeon. This team-based approach has not been previously reported in the pediatric cervical spine literature.

Methods:
A single-institution review of pediatric cervical spine instrumentation and fusion performed by a surgical team composed of neurosurgery and orthopedics during 2002–2020 was performed. Demographics, presenting symptoms and indications, surgical characteristics, and outcomes were recorded. Particular focus was given to describe the primary surgical responsibility of the orthopedic surgeon and the neurosurgeon.

Results:
A total of 112 patients (54% male) with an average age of 12.1 (range 2–26) years met the inclusion criteria. The most common indications for surgery were os odontoideum with instability (n=21) and trauma (n=18). Syndromes were present in 44 (39%) cases. Fifty-five (49%) patients presented with preoperative neurological deficits (26 motor, 12 sensory, and 17 combined deficits). At the time of the last clinical follow-up, 44 (80%) of these patients had stabilization or resolution of their neurological deficit. There was 1 new postoperative neural deficit (1%). The average time between surgery and successful radiologic arthrodesis was 13.2±10.6 mo. A total of 15 (13%) patients experienced complications within 90 days of surgery (2 intraoperative, 6 during admission, and 7 after discharge).

Conclusions:
A multidisciplinary 2-surgeon approach to pediatric cervical spine instrumentation and fusion provides a safe treatment option for complex pediatric cervical cases. It is hoped that this study could provide a model for other pediatric spine groups interested in implementing a multi-specialty 2-surgeon team to perform complex pediatric cervical spine fusions.

Level of Evidence:
Level IV—case series.
Association of Sublingual Microcirculation Parameters and Capillary Refill Time in the Early Phase of ICU Admission*
Authors: Huang Weipeng , Xiang Hui , Hu Chang , Wu Tong , Zhang Dandan , Ma Siqing , Hu Bo , Li Jianguo 
Published: March 2023

Objectives:
This observational study was conducted to investigate capillary refill time (CRT) during the early phase of ICU admission in relationship with microvascular flow alteration and outcome in critically ill patients.

Design:
Prospective, observational, pilot study.

Setting:
ICU in a university hospital.

Patients:
Two hundred eighty-two critically ill adult patients admitted to the ICU.

Interventions:
None.

Measurements and Main Results:
All patients underwent simultaneous measurements by CRT and sidestream dark field imaging within 24 hours of ICU admission. Other clinical data such as demographic characteristics, hemodynamics, laboratory values, treatment, and physiologic parameters were also included simultaneously. Microcirculatory measurements were performed at 10.2 ± 5.7 hours after ICU admission. Of the 282 included patients, 106 (37.6%) were female, the median (interquartile range) age was 63 years (53–74 yr), and the median Sequential Organ Failure Assessment (SOFA) score was 5 (2–7). The primary finding was the association between CRT and simultaneous the condition of peripheral circulation (microvascular flow index [MFI]: r = –0.4430, p < 0.001; proportion of perfused vessels: r = –0.3708, p < 0.001; heterogeneity index: r = 0.4378, p < 0.001; perfused vessel density: r = –0.1835, p = 0.0020; except total vessel density: p = 0.9641; and De Backer score: p = 0.5202) in critically ill patients. In addition, this relationship was also maintained in subgroups. Microcirculatory flow abnormalities, 28-day mortality, and SOFA score appeared to be more severe for increasing CRT. In a multivariable analysis, prolonged CRT was independently associated with microvascular flow abnormalities (MFI < 2.6; odds ratio [OR], 1.608; 95% CI, 2.1–10.2; p < 0.001). Similarly, multivariable analysis identified CRT as an independent predictor of 28-day mortality (OR, 1.296; 95% CI, 1.078–1.558; p = 0.006).

Conclusions:
In our ICU population, a single-spot prolonged CRT was independently associated with abnormal microcirculation and increased mortality.
Universal screening for Lynch syndrome in operated colorectal cancer by immunohistochemistry: a cohort of patients in Liaoning province, China
Authors: Zhao Guangyue , Xiang Guoqing , Hu Xiaoru , Qiao Yun , Ma Shiyang , Tian Ye , Gao Xiaozuo , Liu Fang , Li Xiaohan , Shi Gang 
Published: March 2023

Objective
Lynch syndrome (LS) is the most common hereditary colorectal cancer syndrome worldwide. Due to the decreasing family size in Liaoning province. The Bethesda and Amsterdam II criteria have lower sensitivity and specificity and are not suitable for the local population. Immunohistochemistry screening for mutations in DNA mismatch repair (MMR) in newly diagnosed colorectal cancer can improve the detection rate of LS.

Methods
All newly diagnosed colorectal cancer patients who underwent surgery between January 2018 and June 2020 at Cancer Hospital of China Medical University and Shengjing Hospital of China Medical University from Liaoning China were included retrospectively, and the ratio of universal LS screening by immunohistochemistry, MMR protein deficiency (dMMR) ratio, MLH1 loss, MSH2 loss, MSH6 loss, and PMS2 loss was analyzed. The clinicopathological characteristics of patients with pMMR and dMMR were analyzed.

Results
A total of 7019 colorectal cancer patients underwent surgery and 4802 (68.41%) patients were screened by immunohistochemistry for MMR, 258 (5.37%) cases were reported to have a loss of MMR expression. In the dMMR group, a higher number of patients were under 50 years old, more tumors were located at the right colon, less patients have lymph node metastasis, more tumors were stage II, and histological types of mucinous carcinoma or signet ring carcinoma were more common, compared with the pMMR group. Only 2.71% dMMR patients meet Amsterdam criteria II, 2.71% of patients meet Revised Bethesda guidelines, and 17.83% meet Chinese LS criteria. Twenty-five dMMR patients were confirmed by next-generation sequencing and five families were confirmed as Lynch family.

Conclusion
These data imply that universal screening for LS by immunohistochemistry may be effective in Liaoning province.
Quality of Social Relationships with Parents and Peers in Adolescents Born Extremely Preterm
Authors: Taylor H. Gerry , Hoskinson Kristen R. , Vrantsidis Daphne M. , Minich Nori Mercuri , Busch Tyler , Horn Timothy , Mattson Whitney I. , Nelson Eric E. 
Published: March 2023

ABSTRACT:

Objective:
Adolescents born extremely preterm (EPT, gestational age [GA] <28 weeks) are at higher risk for problems in peer socialization than those born full-term (FT, GA >36 weeks). This study was designed to examine the possibility that adolescents born EPT may also have difficulty in transitioning from parents to peers for socialization, a process referred to as “social reorienting.” A secondary aim was to investigate associations of social reorienting with other neurodevelopmental characteristics.

Methods:
The Network of Relationships Inventory, Relationship Quality Version was administered to 24 adolescents (ages 11–16 years) born EPT and 29 born FT to obtain self-ratings of closeness and discord with parents and peers. Measures of other neurodevelopmental characteristics included tests of cognitive and social skills, adolescent self-ratings of adjustment and victimization, and parent ratings of youth behavior and adaptive skills. Mixed model analyses controlling for sex, socioeconomic status, and race were conducted to examine group differences in measures of relationship quality and their associations with other neurodevelopmental characteristics.

Results:
The EPT group had higher ratings of closeness with parents than the FT group. For adolescents from lower socioeconomic backgrounds, those born EPT had lower closeness with peers. Higher closeness with parents was associated with lower test scores. Lower closeness and more discord with peers were associated with more behavior problems.

Conclusion:
Findings suggest that adolescents born EPT have difficulties in social reorientation toward peers and identify factors related to these difficulties. Results imply a need for interventions to improve peer socialization in youth born EPT.