bluuebunny/crossref_metadata_2025_split huggingface dataset:
LRRC75A-AS1 Inhibits Chondrogenic Differentiation of Bmscs via Targeting
the Mir-140-3p/Wnt/Β-Catenin Pathway
Authors: Shen Pengfei , Wang Bin , Zheng Chong , Pei Jie , Gan Daofu , Xie Zikang 
Published: January 2023

Background:
Bone marrow mesenchymal stem cells (BMSCs) are pluripotent cells with the
ability to differentiate into adipocytes, chondrocytes, and osteoblasts. BMSCs are widely used in regenerative
medicine and cartilage tissue engineering. Role of lncRNA LRRC75A-AS1 (leucine-rich repeat containing
75A antisense RNA 1) in the chondrogenic differentiation of BMSCs was investigated in this study.

Methods:
BMSCs were isolated from rat bone marrow and then identified using flow cytometry. Alcian
blue staining was used to detect chondrogenic differentiation. The effect of LRRC75A-AS1 on chondrogenic
differentiation was assessed by western blot. The downstream target of LRRC75A-AS1 was determined
by dual luciferase activity assay.

Results:
BMSCs were identified with positive CD29 and CD44 staining and negative staining of CD34
and CD45. LRRC75A-AS1 was decreased during the chondrogenic differentiation of BMSCs. Silencing
of LRRC75A-AS1 increased collagen II (COL II), aggrecan and SOX9 and promoted chondrogenic differentiation.
However, over-expression of LRRC75A-AS1 inhibited chondrogenic differentiation. miR-
140-3p was increased during chondrogenic differentiation and interacted with LRRC75A-AS1. miR-140-
3p bind to wnt3a, and inhibition of miR-140-3p up-regulated wnt3a and nuclear β-catenin expression.
Wnt3a and nuclear β-catenin were decreased during chondrogenic differentiation. Inhibition of miR-140-
3p attenuated LRRC75A-AS1 deficiency-induced up-regulation of COL II, aggrecan and SOX9.

Conclusion:
LRRC75A-AS1 suppressed chondrogenic differentiation of BMSCs through down-regulation
of miR-140-3p and up-regulation of the wnt/β-catenin pathway.
Assessment of antibacterial activity of some extracts of Securinega virosa (Roxb. ex Willd.) Baill on pathogens bacteria
Authors: KOUANGBE Mani Adrien , TCHUMOU Messou , KONE Monon , OUATTARA Karamoko , N’GUESSAN Jean David 
Published: January 2023

Today, faced with the emergence of microbial resistance to antibiotics, the renewal of the arsenal of anti-infective drugs is acutely posed. In order to explore other sources of anti-infective drugs, this study therefore proposed to evaluate the antibacterial activity in vitro of several extracts of Securinega virosa, a well-known combretacea of populations in northern Côte d'Ivoire. To achieve this objective, the method of determining the diameters of the zones of inhibition on wells in an agar medium as well as that of the minimum inhibitory concentration (MIC) and the minimum bactericidal concentration were carried out. The results showed that the aqueous extract was not active on all the bacteria tested. The dichloromethane fraction at 500 mg/mL inhibited growth of Shigella Typhi (12.5 mm), followed by Streptococcus sp. (12.33 0.25 mm) and Staphylococcus aureus Meti-R (11.75 1.25 mm). The ethyl acetate fraction inhibited primarily Gram-positive bacteria with average diameters of 12 mm to 500 mg/mL. The ethanol fraction was most active on all bacteria with inhibition diameters ranging from 9 to 13.33 mm to 500 mg/mL. It showed the lowest MIC (3.12 mg/mL) on gram-positive and large Gram-negative levels ranging from 12.5 to 50 mg/mL. This study through its results provides data in favor of the traditional use of Securinega virosa in therapy.
Keywords : Securinega virosa, in vitro, antibacterial, activity
Direct nose-to-brain delivery of diazepam via trigeminal nerve contributes to rapid seizure suppression in pentylenetetrazole-induced status epilepticus model rats
Authors: Watanabe Kazutoshi , Kimura Soichiro , Hazama Yutaro , Morimoto Yasunori , Ueda Hideo 
Published: January 2023

The purpose of our present study was to elucidate the involvement of the direct transfer to the brain after intranasal (i.n.) administration of diazepam (DZP), and to provide findings whether i.n. the administration could be used to obtain rapid onset of pharmacological action. We determined the blood and brain kinetics of DZP after administrations of i.n. and other routes, and the relationship between their concentrations and rapid seizure suppression effect; furthermore, and evaluated the distribution process of DZP to the brain. There was a negative connection between the plasma concentration and the amount of DZP delivery to the brain from the systemic circulation during the period that followed intravenous and intrarectal injection before the onset of seizure suppression. I.n. administration resulted in the seizure suppression time below the correlation curve: the seizure suppression effects were observed earlier than estimated despite the low plasma concentrations of DZP, suggesting the involvement of direct nose-to-brain delivery of DZP. The time to maximum concentration (Tmax) in the forebrain, hindbrain, olfactory bulb (OB), trigeminal nerve (TN), and cerebrospinal fluid (CSF) after i.n. the administration was 3 min, which was shorter than the Tmax of the plasma concentration. In fluorescence imaging using Rhodamin-B-base, the TN and the area of the vicinity of the thalamus had stronger fluorescence 1 and 3 min after i.n. administration, compared with the OB and CSF. In summary, direct brain delivery of DZP requires the TN and it was suggested that distribution to the vicinity of the thalamus via the TN may be connected to the quick seizure suppression effect.
Keywords: Status Epilepticus, Diazepam, Intranasal Administration, Nose-to-Brain, Trigeminal Nerve
The Potentials of Herbal Plant against the Psoriasis
Authors: Sanap Jayshree B , Chandewar Anil V. , Kochar Nitin , Nagrik Shatrughna Uttam 
Published: January 2023

Chronic autoimmune skin disease termed psoriasis is characterised by excessive keratinocyte multiplication, scaly plaques, severe inflammation, and erythema. T lymphocytes, leukocytes, vascular endothelium, and epidermal keratinocytes also contribute in the pathogenesis of psoriasis. Increased leukocyte recruitment and increased levels of cytokines, growth factors, and genetic factors like interleukin (IL)-1, IL-6, IL-17, IL-22, IL-23, tumour necrosis factor (TNF), interferon (IFN), transforming growth factor (TGF), toll-like receptor (TLR)-2, signal transducer and activator of transcription (STAT-3), 15-lipoxygenase (LOX)-2. The most important aspects impacting the treatment of psoriasis are coiled-coil alpha-helical rod protein 1 (CCHCR1), steroidogenic acute regulatory protein (StAR), and vitamin D receptor (VDR). Various synthetic medicinal drugs have also been known to have the side effect of psoriasis. Due to their safety and accessibility, herbal medications may indicate the potential as effective anti-psoriatic agents.
Keywords: Psoriasis, Herbal Drug, Silybum marianum, Thespesia populnea, Mahonia aquifolium
United States Facility Management Industry Demographic Trends and Contemporary Workforce Challenges
Authors: Call Steven 
Published: January 2023

ABSTRACT

Purpose -
The purpose of this research is to better understand the current state of the United States' FM profession by evaluating workforce demographic trends in identifying contemporary recruitment and hiring challenges facing the FM industry.

Methodology -
A survey was developed based upon available literature including past research and industry surveys. Demographic information was sought to understand respondents gender, race, ethnicity, age, retirement timeframes, and educational attainment. Input from a panel of FM subject matter experts was also secured prior to completion of the survey. The survey was sent electronically in February 2021 to more than 12,400 members of IFMA; a total of 3,557 survey responses were received by April 2021 for a 29 percent response rate. Only information from the 2,069 US respondents was used in this research.

Findings -
The US FM industry is getting younger, in part due to the growing number of FM college graduates. Nevertheless, a majority of facility managers will be retiring within the next decade and adoption of FM succession planning is sluggish. While recruitment of entry-level FM talent has become easier, recruiting senior level FM talent is a major challenge. Furthermore, there has been relatively no growth in the portion of females and minorities making up the FM workforce population over the past decade. Understanding challenges related to recruitment and succession of senior level FM profession, and a more inclusive workforce, is imperative for the FM industry to better attract and sustain a competent and diverse workforce.

Originality/value -
The results of this research are valuable in understanding current recruitment, retention, and hiring challenges within FM to help the industry address historical workforce attrition concerns.
Treatment of Molar-incisor Hypomineralization: A Case Report of 11-year Clinical Follow-up
Authors: Vieira APM , Emerenciano NG , Moda MD , Silva ÚAE , Fagundes TC , Danelon M , Cunha RF 
Published: January 2023

SUMMARYThe purpose of this case report was to describe an 11-year follow-up of a patient presenting with molar-incisor hypomineralization (MIH) having yellowish and porous permanent incisors and molars. Clinical examination revealed demarcated brown opacities on one upper and one lower central incisor and three first permanent molars. Initially, treatment involved oral hygiene and periodic fluoride varnish application. Subsequently, the occlusal surfaces of the affected molars were restored or sealed with glass ionomer cement. At-home dental bleaching was also performed. Areas of unsatisfactory esthetics on the incisors were replaced by composite resins. This report discussed the patient’s needs and expectations, the difficulties of prolonged treatment for patients with MIH, and the restorative protocol involving at-home dental bleaching and composite resins.
batalha digna de Ogum e Tupã
Authors: Pomin Fabiana , Café Lucas Santos 
Published: January 2023

Este estudo analisa a inclusão da história e cultura afro-brasileira e indígena nas aulas de Educação Física, em consonância com as políticas educacionais. Observou-se a prática no Ensino Fundamental I e II e Médio, das redes municipal, estadual e federal da cidade de Primavera do Leste (MT). Realizou-se pesquisa descritiva quanti-qualitativa, tendo como instrumento de coleta de dados questionário virtual autoaplicado; a avaliação dos resultados ocorreu por meio de leitura flutuante (com análise de conteúdo). Constatou-se que, no Município e no Estado, há uma consistente presença do conteúdo, inclusive por variados eixos. Porém, na rede federal, em que os professores atuam apenas no Ensino Médio, não há desenvolvimento da temática étnico-racial.
Apresentação do dossiê Produção e Política Cultural
Authors: Machado Sátira Pereira , Melo Alan Dutra de 
Published: January 2023

Neste dossiê da Relacult apresentamos a edição temática marcando os 10 anos do Curso de Bacharelado em Produção e Política Cultural (PPC) da Universidade Federal do Pampa (Unipampa), ofertado no Campus Jaguarão – cidade do Rio Grande do Sul que faz fronteira entre o Brasil e o Uruguai, criado em 2011. Celebramos os 10 anos do Curso de Bacharelado em Produção e Política Cultural da Universidade Federal do Pampa, Campus Jaguarão, com alegria. Em tempos de ataques ao campo da cultura comemorar estes feitos realizados torna-se um ato de resistência e reconhecimento aos/às pesquisadores/as envolvidos/as nesse dossiê que compõem as edições da Revista RELACult da Editora do Centro Latino-Americano de Estudos em Cultura (CLAEC).
Apresentação
Authors: Ribeiro Angela Mara , Machado Carlos José de Azevedo 
Published: January 2023

Apresentação da edição especial dos estudos apresentados no Seminário integrador: Turismo: da Fronteira à Serra – Jaguarão – Bento Gonçalves – RS, parte do projeto do Grupo de Pesquisa Turismo, Fronteira e Desenvolvimento, registrado na UNIPAMPA e vinculado na plataforma CNpq, pela Universidade Federal do Pampa – UNIPAMPA, localizada em Jaguarão-RS fronteira com a cidade uruguaia Rio Branco. O evento é uma parceria com Instituto Federal de Educação, Ciência e Tecnologia do Rio Grande do Sul - IFRS - Campus de Bento Gonçalves- RS.
La race noire dans les discours des politiciens et intellectuels du XIXe siècle en Haïti
Authors: Pierre André Yves 
Published: January 2023

Une fois indépendant le Premier Janvier 1804, Haïti, devient le seul pays où une révolution d’esclave noir importé d’Afrique a connu une victoire sur le système colonial et esclavagiste imposé par les Européens. Cette victoire sur l’esclavage et la colonisation est aussi la victoire de la race noire contre les abus du système esclavagiste Européen. En effet, au lendemain de l’indépendance, les discours Pères Fondateurs allaient s’imposer comme príncipe pour garentir la cohésion sociale. Et plus tard les differents écrivains étrangers ont dressé un tablaeu sombre sur les rapports entre les races en Haïti. C’est ainsi que, des intellectuels volent au secours de la race en imposant une «race noire haïtienne» comme étant le modèle de fièrete pour les autres peuples noirs et aussi l’égalité entre les races puis d’autres intellectuels aussi ont pris la défense tous les discours racistes contre Haïti. Pour réaliser ce travail, nous utilisons la méthode qualitative en s’appuiyant sur des sources et documents du XIXe siècle pour voir et comprendre les discours des politiciens et intellectuels Haïtiens de cette époque. Et c’est ainsi nous avons conclut qu’il existe (3) types de discours, d’abord un discours politique, ensuite, un discours scientifique et enfin un discours de défense ou de réhabilitation du nègre haïtien.
The effects of expressive writing intervention in cancer patients and survivors: A rapid umbrella review
Authors: Parv Dorra 
Published: January 2023

Objectives:
Numerous primary studies and systematic reviews, both with and without meta-analyses, examined the effects of expressive writing intervention (EWI), yielding mixed and inconsistent findings. The purpose of this review was to assess the effects of EWI on health outcomes in cancer patients using systematic reviews with or without meta-analyses.

Materials and Methods:
Google Scholar, Google, and Yahoo search engines and the Cochrane databases of systematic reviews published between 1986 and October 2019 were used to conduct the searches. Five studies met all of the criteria for inclusion. According to the AMSTAR tool, 80% of the included studies achieved a moderate level of methodological quality, while the remaining 20% achieved a low level of methodological quality.

Results:
There were no consistent or robust findings regarding expressive writing effects, with some studies (40%, n = 2) indicating that expressive writing has no general effectiveness. In comparison, others (40%, n = 2) indicated that expressive writing affects only physical health outcomes, and only one study (20%, n = 1) indicated that expressive writing has a general effect. In addition, several studies (40%, n = 2) discovered a moderating effect.

Conclusion:
In summary, the findings of this narrative overview indicate that there are mixed or inconsistent findings and several moderators regarding expressive writing effects in the cancer population, implying that substantial clinical heterogeneity and deviation from Pennebaker and Beal’s, 1986, initial experiment, as well as some moderating variables, may account for this finding. Thus, future primary and review studies should employ a more rigorous methodology and greater homogeneity, notably similar to that of Pennebaker and Beal’s original study in 1986, to replicate their initial findings.
The Impact Of Online Learning For Teachers In Remote Areas
Authors: Tuminah Tuminah , Selong Yustina , Nur Cahyoko Kunto 
Published: January 2023

Online learning in remote areas is certainly not as easy as online learning in big cities in Indonesia. Online learning in remote areas, especially in the Landak district, faces many obstacles due to limited facilities and infrastructure. To overcome these problems, teachers in remote areas in Landak are trying to find solutions so that online learning can still take place well, even though it is limited. This study aims to describe the difficulties experienced by teachers when teaching and the solutions offered to overcome the problems of online learning in these remote areas. The results of this study indicate that there are still some difficulties encountered related to online learning experienced by teachers in remote areas. Difficulties in the internet network and the provision of laptops or smartphones still color the implementation of online learning experienced by teachers in remote areas. 84% of teachers experienced network difficulties in the online learning process during the pandemic. One thing is very proud that teachers in remote areas are willing to do anything to overcome these difficulties. So even though there are many difficulties faced by online learning in remote areas, it can still run well. One of the efforts made is blended learning, taking turns online and offline learning.
Pelatihan Bahasa Inggris Untuk Masyarakat Hinterland Dalam Pengembangan Kampung Wisata Pasir Panjang
Authors: Siahaan Arta Uly , Antoni Condra , Aji Satria Bayu , Handayani Yosi , Fatulloh Agus , Kirana Mira Chandra , Nelmiawati Nelmiawati , Yulius Rina , Fani Maidel , Sari Festy Winda , Riki Riki , Firmanda Ardiman , Puspita Roza , Idris Muhammad 
Published: January 2023

Nowadays, English should be mastered by all level of people and for all ages namely for children, teenagers or adults. There is a special challenge for improving the ability especially for hinterland society. For Rempang Cate citizen which is one of tourism destination in Batam, it is still far from the expectation. The idea of this community service is to improve the communication as the tourist destination host especially English for tourism. Finally, by giving this training to them, it is expected that they are able to attract more tourst to visit this place. The method of this community service is by giving training to three levels of class by providing material related to simple conversation fo tourism. Based on general result of questionnaire, everything ran well and no obstacles and difficulties happened to organize this training. It was very helpful to improve the readiness of the society to welcome the tourist.
Pemberdayaan Masyarakat Pulau Akar Melalui Pengajaran Bahasa Inggris, Marketing dan Digital Technology Menjadi Kampung Wisata
Authors: Hulu Fasaaro , Saragih Saut Pintubipar , Afridola Sri 
Published: January 2023

Abstrak - Pengabdian ini berkaitan dengan pengajaran bahasa inggris, marketing dan digital technology kepada masyarakat kampung Pulau Akar Batam. Kegiatan ini bertujuan untuk dapat berkomunikasi dalam bahasa inggris dengan turis asing, warga kampung Pulau Akar dapat memasarkan dan mempromosikan objek wisatanya dan mampu menggunakan teknologi digital serta internet sebagai media publikasi tourism activities sehingga bisa terhubung banyak orang dalam dan luar negeri. Kegiatan dilaksanakan di Kampung Pulau Akar, Kelurahan Setokok, Kecamatan Bulang, Batam dan peserta terdiri dari anak sekolah, guru dan pengemudi pancung. Metode yang diterapkan adalah perkenalan diri, presentasi, diskusi, ceramah dan praktek. Hasil dari pengabdian ini adalah peserta mendapatkan peningkatan keterampilan berkomunikasi menggunakan bahasa inggris, memperoleh pengetahuan untuk membuat promosi wisata, dan produk lokal serta mahir menggunakan teknologi digital dan internet demi memperkenalkan dimata dunia kegiatan dan objek wisata Kampung Pulau Akar

Kata Kunci: Pengabdian, bahasa inggris, promosi wisata, teknologi digital
PkM Kopontren Daarul Rahman Cipedak Jagakarsa Jakarta Selatan melalui Kewirausahaan Syariah berbasis Smartphone
Authors: Murdayanti Yunika , Indriani Susi 
Published: January 2023

Eksistensi Koperasi Pondok pesantren dapat ditinjau melalui tiga dimensi yaitu sebagai pendukung mekanisme kehidupan ekonomi Pondok pesantren, sebagai pembinaan kader koperasi pedesaan dan sebagai stimulator sosio-ekonomi masyarakat desa di sekitar Ponpes. Namun terdapat permasalahan yaitu minimnya akses pengetahuan dan program pendidikan kewirausahaan bagi para santri akan memunculkan kekhawatiran akan semakin tertinggalkan pemahaman intelektual maupun keterasahan softskill mereka.
Metode pelaksanaan pengabdian ini dilakukan di Koperasi Pondok Pesantren Daarul Rahman Jakarta Selatan melalui wawancara, ceramah mengenai materi pelatihan, praktik dan diskusi pelatihan pencatatan persediaan dan keuangan menggunakan aplikasi teknologi informasi baik dengan program komputer ms excell dan aplikasi digital berbasis smartphone.
Pencapaian hasil kegiatan ini adalah peningkatan kemampuan keterampilan manajerial dan memiliki kemampuan menggunakan teknologi informasi dalam pengaplikasiannya pada pencatatan keuangan digital.
Eksistensi Koperasi Pondok pesantren dapat ditinjau melalui tiga dimensi yaitu sebagai pendukung mekanisme kehidupan ekonomi Pondok pesantren, sebagai pembinaan kader koperasi pedesaan dan sebagai stimulator sosio-ekonomi masyarakat desa di sekitar Ponpes. Namun terdapat permasalahan yaitu minimnya akses pengetahuan dan program pendidikan kewirausahaan bagi para santri akan memunculkan kekhawatiran akan semakin tertinggalkan pemahaman intelektual maupun keterasahan softskill mereka.
Metode pelaksanaan pengabdian ini dilakukan di Koperasi Pondok Pesantren Daarul Rahman Jakarta Selatan melalui wawancara, ceramah mengenai materi pelatihan, praktik dan diskusi pelatihan pencatatan persediaan dan keuangan menggunakan aplikasi teknologi informasi baik dengan program komputer ms excell dan aplikasi digital berbasis smartphone.
Pencapaian hasil kegiatan ini adalah peningkatan kemampuan keterampilan manajerial dan memiliki kemampuan menggunakan teknologi informasi dalam pengaplikasiannya pada pencatatan keuangan digital.
Sosialisasi Antisipasi Penyebaran Covid-19 melalui Buku Panduan dan Vidio Animasi Sebagai Penunjang Stabilitas Perekonomian Masyarakat di Kota Batam
Authors: Utama Doni Putra , Kartikasari Dwi , Hati Shinta Wahyu , Hendrawan Bambang , Handayani Yosi , Wirawan Adhitomo , Mulyana Andi Erna , Syafrina Mia , Puspitasari Ayu , Harlan Fandy Bestario 
Published: January 2023

Di awal tahun 2020, dunia digemparkan dengan merebaknya virus baru yaitu corona virus jenis baru (SARS-CoV-2) dan penyakitnya disebut Coronavirus disease 2019 (COVID-19). Begitu juga halnya di Provinsi Kepulauan Riau Khususnya Kota Batam menjadi zonasi merah terdampak COVID-19, akan tetapi masih banyak masyarakat setempat yang melakukan aktivitas demi menghidupi keluarganya. Berdasarkan latar belakang yang sudah dijelaskan di atas maka para pengabdi berfokus pada pembuatan penyusunan buku panduan dan media animasi agar informasi pencegahan COVID-19 tersampaikan kepada masyarakat setempat demi menjaga stabilitas ekonomi masyarakat Adapun tujuan dari Kegiatan Pengabdian Masyarakat ini adalah untuk membuat, menyusun dan menyebarkan Buku Panduan non otoritatif pencegahan Covid-19 agar masyarakat memiliki kesadaran dan berpartisipasi meminimalisir penyebaran virus corona di Batam, merancang dan menyebarkan vidio animasi panduan pencegahan Covid-19 agar masyarakat memiliki kesadaran dan berpartisipasi meminimalisir penyebaran virus corona di Batam, mensosialisasikan edukasi buku panduan dan vidio animasi agar masyarakat menjaga kesehatan dan keselamatan di masa Pandemi Covid-19, mensosialisasikan edukasi buku panduan dan vidio animasi sebagai penunjang stabilitas ekonomi masyarakat. Program kegiatan Pengabdian Kepada Masyarakat Jurusan Manajemen Bisnis Politeknik Negeri Batam sudah dilaksanakan dan berjalan dengan baik yang diikuti oleh seluruh kalangan dan sektor di Kota Batam