bluuebunny/crossref_metadata_2025_split huggingface dataset:
C‐programming self‐assessment exercises versus final exams: 12 years of experience
Authors: Rodríguez‐Vidal Javier , Martínez Raquel , García‐Beltrán Ángel 
Published: May 2023

AbstractThe new curricula derived from the Bologna process encourage continuous evaluations during the teaching period. This situation causes already depleted teachers to have an additional workload during the course, so the emergence of tools that automatically evaluate this work is necessary. In computer science, the ideal evaluation technique would be to use automatic code evaluators (such as C, Java, C++, etc.). The main objective of this work is to analyze whether the use of C‐coding self‐assessment exercises correlates with an improvement in exam performance. For this purpose, the implementation of self‐assessment exercises on the AulaWeb platform during the last 12 academic years (2010/2011–2021/2022) in a Programming Fundamentals course (Fundamentos de Programación) in an engineering faculty at the Universidad Politécnica de Madrid (UPM) was collected. The main tasks carried out in this research have been: (i) recovery and analysis of the information collected from the AulaWeb platform and (ii) the study of the influence of the self‐assessment exercises on the final grades obtained by the students of the course through correlations. The most important findings are: (a) self‐assessment exercises generate experience and confidence when facing problems (this situation translates into a higher probability of passing the course) and (b) self‐assessment exercises influence the final exams taken at the end of the semester, mainly due to the short time between the end of classes and the exam. Self‐assessment exercises provide valuable information for teachers to monitor the progress of large groups of students during the semester and for students to pass exams.
FFT‐based efficient Poisson solver in nonrectangular domain
Authors: Wang Yunong , Hou Fei , Wang Wencheng 
Published: May 2023

AbstractPoisson's equation is one of the most popular partial differential equation (PDE), which is widely used in image processing, computer graphics and other fields. However, solving a large‐scale Poisson's equation always costs huge computational resources. Fast Fourier transform (FFT) is an efficient Poisson solver but it only works in rectangular domain. In this paper, we propose a FFT‐based Poisson solver in nonrectangular domain on regular grids combined with algebraic multigrid (AMG). We extend the original Poisson's equation to a rectangular domain to construct an equivalent equation, so that it can use FFT algorithm to accelerate the solving to Poisson's equation. Experiments show that the FFT‐based Poisson solver can improve the solving speed of large‐scale Poisson's equations in nonrectangular domain. We demonstrate the solver in applications of image processing and fluid simulation.
Facile Production of the Pseudomonas aeruginosa Virulence Factor LasB in Escherichia coli for Structure‐Based Drug Design
Authors: Kolling Dominik , Haupenthal Jörg , Hirsch Anna K. H. , Koehnke Jesko 
Published: May 2023

AbstractThe human pathogen Pseudomonas aeruginosa has a number of virulence factors at its disposal that play crucial roles in the progression of infection. LasB is one of the major virulence factors and exerts its effects through elastolytic and proteolytic activities aimed at dissolving connective tissue and inactivating host defense proteins. LasB is of great interest for the development of novel pathoblockers to temper the virulence, but access has thus far largely been limited to protein isolated from Pseudomonas cultures. Here, we describe a new protocol for high‐level production of native LasB in Escherichia coli. We demonstrate that this facile approach is suitable for the production of mutant, thus far inaccessible LasB variants, and characterize the proteins biochemically and structurally. We expect that easy access to LasB will accelerate the development of inhibitors for this important virulence factor.
Comparison of quantitative flow ratio with instantaneous wave‐free ratio and resting full‐cycle ratio during daily routine in the catheterization laboratory
Authors: Stader Jannis , Antoniadis Marios , Ussat Matti , Wachter Rolf , Lavall Daniel , Metze Michael , Neef Martin , Spies Christian , Laufs Ulrich , Lenk Karsten 
Published: May 2023

AbstractBackgroundQuantitative flow ratio (QFR) is a novel, software‐based method to evaluate the physiology of coronary lesions. The aim of this study was to compare QFR with the established invasive measurements of coronary blood flow using instantaneous wave‐free ratio (iFR) or resting full‐cycle ratio (RFR) in daily cathlab routine.Methods102 patients with stable coronary artery disease and a coronary stenosis of 40%−90% were simultaneously assessed with QFR and iFR or RFR. QFR‐computation was performed by two certified experts using the appropriate software (QAngio XA 3D 3.2).ResultsQFR showed a significant correlation (r = 0.75, p < 0.001) to iFR and RFR. The area under the receiver curve for all measurements was 0.93 (95% confidence interval, 0.87–0.98) for QFR compared to iFR or RFR. QFR based assessment required less time with a median of 501 s (IQR 421–659 s) compared to iFR or RFR which required a median of 734 s to obtain the result (IQR 512–967 s; p < 0.001). The median use of contrast medium was similar with 21 mL (IQR 16–30 mL) for the QFR‐based and 22 mL (IQR 15–35 mL) for the iFR‐ or RFR‐based diagnostic. QFR diagnostic required less radiation. The median dose area product for QFR was 307cGycm2 (IQR 151–429 cGycm2) compared to 599 cGycm2 (IQR 345–1082 cGycm2) for iFR or RFR, p < 0.001.ConclusionQFR measurements of coronary artery blood flow correlate with iFR or RFR measurements and are associated with shorter procedure times and reduced radiation dose.
Hairy cell leukemia with isolated bone lesions
Authors: Cailly Laura , Gruchet Cécile , Maitre Elsa , Guidez Stephanie , Delwail Vincent , Systchenko Thomas , Moya Niels , Sabirou Florence , Levy Anthony , Bobin Arthur , Gardeney Hélène , Nsiala Laly , Vonfeld Mathilde , Chacon Aurélia , Pichon Aurélien , Bouyer Sabrina , Baslé Caroline , Dindinnaud Elodie , Chomel Jean‐Claude , Raimbault Anna , Borde‐Mougenot Florence , Troussard Xavier , Tomowiak Cécile 
Published: May 2023

Key Clinical Message18F‐FDG PET/CT has clinical relevance in HCL at diagnosis and for the follow‐up of patients treated, especially in case of atypical presentations such as bone involvements (which are probably underestimated) and poor bone marrow infiltration.AbstractBone lesions are rarely reported in Hairy Cell Leukemia (HCL). We report two BRAFV600E mutated HCL patients presented bone lesions at foreground, poor bone marrow involvement, and the important role 18F‐FDG PET/CT played in their management. We discuss the crucial role that 18F‐FDG PET/CT could play in HCL routine practice.
Strong Chiroptical Effects in the Absorption and Emission of Macrocycles Based on the 2,5‐Diaminoterephthalate Minimal Fluorophore
Authors: Nowak Krzysztof , Morawski Olaf , Zinna Francesco , Pescitelli Gennaro , Di Bari Lorenzo , Górecki Marcin , Grzybowski Marek 
Published: May 2023

AbstractChiral fluorescent macrocycles consisting of two to four units of dimethyl 2,5‐diaminoterephthalate can be readily synthesized in a one‐pot manner from inexpensive building blocks. Depending on the concentration, either a paracyclophane‐like dimer with closely stacked benzene rings or a triangular trimer is the main product of the reaction. The macrocycles exhibit fluorescence in solution as well as in the solid state with maxima that are red‐shifted with decreasing size of the macrocyclic ring and are observed at wavelengths from 590 (tetramer in solution) to 700 nm (dimer in the solid state). Chirality dictates the differential absorption and emission of circularly polarized light by these molecules. The ECD and CPL effects are particularly strong for the trimer, which is characterized by relatively large dissymmetry factors gabs=±2.8×10−3 at 531 nm and glum=±2.3×10−3 at 580 nm in n‐hexane, being at the same time highly luminescent (Φfl=13.7 %). Despite the small chromophore, the circularly polarized brightness BCPL of 2.3 dm3 mol−1 cm−1 is comparable to values reported for other classes of established CPL emitters in the visible region, such as expanded helicenes or larger π‐conjugated systems.
Strong and Tunable Near‐Infrared Circular Dichroism in Helical Tetrapyrrole Complexes
Authors: Urban Adrian Joe , Yamamoto Hiroshi M. 
Published: May 2023

AbstractThe selective synthesis of nickel and copper complexes of 19‐benzoyl‐5,10,15‐triphenyl‐bilatrien‐1‐one (H2TPBT) is reported, a molecule which crystallizes as a molecular helix of one‐and‐a‐quarter which turns with a 5.7 Å radius and a 3.2 Å pitch, and all 26 participating atoms are sp2‐hybridized. UV/vis, ECD, ESR and cyclic voltammetry experiments reveal a strong interaction between metal and ligand and partial radical character when copper is coordinated instead of nickel. Strong ECD absorption in the 800 nm range is found which, using TD‐DFT calculations as well as literature spectra, is shown to be highly tunable both by metal coordination and variation of the aryl groups in the TPBT periphery. The radical character of the ligand in Cu(TPBT) enables rapid interconversion between (M)‐ and (P)‐enantiomers, possibly via intermittent breakage of a Cu−N bond. The 19‐benzoyl group kinetically stabilizes enantiopure (M/P)‐Ni(TPBT). The results are interpreted with regard to the application as circularly polarized light (CPL) detectors as well as to the chirality‐induced spin‐selectivity (CISS) effect which is currently lacking a concise theoretical model.
Cell penetrating peptides: Highlighting points in cancer therapy
Authors: Asrorov Akmal M. , Wang Huiyuan , Zhang Meng , Wang Yonghui , He Yang , Sharipov Mirkomil , Yili Abulimiti , Huang Yongzhuo 
Published: May 2023

AbstractCell‐penetrating peptides (CPPs), first identified in HIV a few decades ago, deserved great attention in the last two decades; especially to support the penetration of anticancer drug means. In the drug delivery discipline, they have been involved in various approaches from mixing with hydrophobic drugs to the use of genetically conjugated proteins. The early classification as cationic and amphipathic CPPs has been extended to a few more classes such as hydrophobic and cyclic CPPs so far. Developing potential sequences utilized almost all methods of modern science: choosing high‐efficiency peptides from natural protein sequences, sequence‐based comparison, amino acid substitution, obtaining chemical and/or genetic conjugations, in silico approaches, in vitro analysis, animal experiments, etc. The bottleneck effect in this discipline reveals the complications that modern science faces in drug delivery research. Most CPP‐based drug delivery systems (DDSs) efficiently inhibited tumor volume and weight in mice, but only in rare cases reduced their levels and continued further processes. The integration of chemical synthesis into the development of CPPs made a significant contribution and even reached the clinical stage as a diagnostic tool. But constrained efforts still face serious problems in overcoming biobarriers to reach further achievements. In this work, we reviewed the roles of CPPs in anticancer drug delivery, focusing on their amino acid composition and sequences. As the most suitable point, we relied on significant changes in tumor volume in mice resulting from CPPs. We provide a review of individual CPPs and/or their derivatives in a separate subsection.
Childhood body mass index and the subsequent risk of anorexia nervosa and bulimia nervosa among women: A large Danish population‐based study
Authors: Leth‐Møller Katja Biering , Hebebrand Johannes , Strandberg‐Larsen Katrine , Baker Jennifer Lyn , Jensen Britt Wang 
Published: May 2023

AbstractObjectiveEvidence linking childhood body mass index (BMI) with subsequent eating disorders is equivocal. Potential explanations include different study populations and size, and that anorexia nervosa (AN) and bulimia nervosa (BN) should be studied separately. We examined whether birthweight and childhood BMI were associated with subsequent risk of AN and BN in girls.MethodWe included 68,793 girls from the Copenhagen School Health Records Register born between 1960 and 1996 with information on birthweight and measured weights and heights obtained from school health examinations at ages 6–15 years. Diagnoses of AN and BN were retrieved from Danish nationwide patient registers. We used Cox proportional hazards regression to estimate hazard ratios (HRs) and 95% confidence intervals (CIs).ResultsWe identified 355 cases of AN (median age: 19.0) and 273 cases of BN (median age: 21.8). Higher childhood BMI was linearly associated with decreasing risk of AN and increasing risk of BN at all childhood ages. At age 6, the HR for AN was 0.85 (95% CI: 0.74–0.97) per BMI z‐score and the HR for BN was 1.78 (95% CI: 1.50–2.11) per BMI z‐score. Birthweight >3.75 kg was associated with increased risk of BN compared to a birthweight of 3.26–3.75 kg.ConclusionHigher BMI in girls at ages 6–15 years was associated with decreasing risk of AN and increasing risk of BN. Premorbid BMI could be relevant for the etiology of AN and BN, and in identifying high risk individuals.Public significanceEating disorders are associated with elevated mortality, especially AN. Using a cohort of Copenhagen school children, we linked information on BMI at ages 6–15 years for 68,793 girls with nationwide patient registers. Low childhood BMI was associated with increased risk of AN, whereas high childhood BMI was associated with increased risk of BN. These findings may assist clinicians in identifying individuals at high‐risk of these diseases.
Picky eating is associated with lower life satisfaction and elevated psychological distress and psychosocial impairment in Chinese pregnant women
Authors: He Jinbo , Zhang Xinyi , Barnhart Wesley R. , Cui Shuqi , Liu Yutian , Zhao Yumeng , Yin Junyu , Tan Chuyi 
Published: May 2023

AbstractObjectiveThis study assessed picky eating in pregnant women by exploring whether picky eating is associated with pregnant women's well‐being, including life satisfaction, psychological distress, and psychosocial impairment.MethodData collected were from 345 Chinese pregnant women ( = 29.95 years, SD = 5.58). Pearson correlation analyses were conducted to examine zero‐order correlations between picky eating and well‐being variables (i.e., life satisfaction, psychological distress, and psychosocial impairment). Hierarchical multiple regressions were conducted to examine the unique associations of picky eating with well‐being variables, adjusting for demographic and pregnancy‐related characteristics and thinness‐oriented disordered eating.ResultsPicky eating was significantly and negatively correlated with life satisfaction (r = −.24,p < .001) and positively correlated with psychological distress (r = .37,p < .001) and psychosocial impairment (r = .50,p < .001). When adjusting for covariates and thinness‐oriented disordered eating, picky eating was still significantly associated with lower life satisfaction, higher psychological distress, and higher psychosocial impairment.DiscussionThe findings suggest that picky eating may be a significant correlate of pregnant women's poorer well‐being. Future research with longitudinal designs is warranted to further examine the temporal associations between picky eating and pregnant women's well‐being.Public SignificancePicky eating behaviors are poorly understood in pregnant women. Our results revealed that higher picky eating behaviors were associated with lower life satisfaction and higher psychological distress and psychosocial impairment in Chinese pregnant women. Researchers and clinicians may consider picky eating in the assessment and treatment of mental health and disordered eating in pregnant women.
Downstream effects: Impact of antibiotic pollution on an aquatic host–parasite interaction
Authors: Melchiorre Hannah G. , Gutierrez Stephanie O. , Minchella Dennis J. , Vannatta J. Trevor 
Published: May 2023

AbstractThe global increase in antibiotic use has led to contamination of freshwater environments. Despite the identified impacts of antibiotics on humans and wildlife, the effect of antibiotics on host–parasite life cycles in freshwater is relatively unexplored. In the current study, we utilize the trematode parasiteSchistosoma mansoni, and its snail intermediate host,Biomphalaria glabrata, to investigate the influence of an ecologically relevant antibiotic concentration on the life history characteristics of both parasite and host. Our results demonstrate that antibiotics not only accelerate parasite development time, but also increase host reproduction and delay parasite‐induced host castration. Using a mathematical model, we suggest that life history alterations associated with antibiotics are likely to increase parasite transmission and disease burden. Our study suggests that antibiotic pollution could impact freshwater ecosystems by influencing host–parasite dynamics and potentially increase the burden of schistosomiasis in endemic regions.
Conspecific density and habitat quality affect breeding habitat selection: Support for the social attraction hypothesis
Authors: Swift Rose J. , Anteau Michael J. , Ellis Kristen S. , Ring Megan M. , Sherfy Mark H. , Toy Dustin L. 
Published: May 2023

AbstractBreeding habitat selection is a critical component of the annual cycle because of its effect on fitness. Multiple theories of habitat selection can be differentiated by their responses to the quantity of habitat, conspecific density, and habitat quality. Here, we use network analysis to understand the characteristics of fine‐scale breeding habitat selected by both immigrant and returning adult piping plovers (Charadrius melodus) to test five hypotheses of habitat selection. Between 2014 and 2019, we recorded 2034 uniquely marked adults breeding at 326 breeding locations with 1240 successive breeding events. Among adults, immigration events (i.e., individuals that moved to a new breeding location) were detected as often as fidelity to the same breeding location. We found support for the social attraction hypothesis for both immigrants and returners, indicating that adult plovers use social cues for settlement decisions. Adult plovers selected habitats with intermediate levels of conspecific density and high habitat quality, as assessed by con‐ and heterospecific nest survival, with no effect from the amount of available habitat. We also simulated the loss of breeding habitat and identified highly connected breeding locations, which occurred mostly on the riverine habitat type, which have important implications for habitat conservation for this listed species. Our results highlight the role of conspecifics at identifying high‐quality breeding habitat regardless of whether individuals return to the same breeding site or immigrate to new areas.
Photocatalytic Oxidative [3+2] Cycloaddition for Pyrrolo[2,1‐a]isoquinoline Synthesis Using a Porphyrin‐Based Covalent Organic Framework
Authors: Wu Cheng‐Juan , Shao Ming‐Zhen , Niu Li‐Jing , Li Ting‐Rui , Liang Wen‐Jing , Kan Jing‐Lan , Geng Yan , Dong Yu‐Bin 
Published: May 2023

AbstractBy using a catalytic amount of a porphyrin‐based covalent organic framework (Por‐Ad‐COF) as the efficient recyclable photocatalyst, the photocatalytic oxidative [3+2] cycloaddition reaction between tetrahydroisoquinolines and N‐substituted maleimides was developed under aerobic conditions at room temperature. Various substituted pyrrolo[2,1‐a]isoquinolines were obtained in moderate to good yields via the dipolar [3+2] cycloaddition and oxidative aromatization cascade process under visible light irradiation. This was the first example to employ the covalent organic framework as the heterogeneous photocatalyst to perform the photocatalytic dipolar [3+2] cycloaddition reaction for the synthesis of pyrrolo[2,1‐a]isoquinolines.
Multizone Aquatic Ecological Exposures to Landfill Contaminants from a Groundwater Plume Discharging to a Pond
Authors: Hua Tammy , Propp Victoria R. , Power Christopher , Brown Susan J. , Collins Pamela , Smith James E. , Roy James W. 
Published: May 2023

Abstract
While it is recognized that groundwater contaminant plumes can impact surface waters, there remains little information on the magnitude, spatial extent, and especially temporal variability of the resulting exposure to the variety of aquatic organisms, particularly for stagnant surface waters (e.g., ponds). The present study of a historic landfill plume discharging to a pond investigated contaminant exposure to multiple aquatic zones (endobenthic, epibenthic, pelagic) over approximately 1 year within a temperate climate. Landfill tracers included the artificial sweetener saccharin, ammonium, chloride, and specific conductance. Sampling of pond sediment porewater (upwelling groundwater) and continuous geophysical imaging of the subsurface showed a relatively stable plume footprint covering approximately 26% of the pond, although with spatially varying leachate composition, revealing year-round exposure to endobenthic (within sediments) organisms. Substantial and variable contaminant exposure to epibenthic organisms within the plume footprint was shown by elevated specific conductance measured directly above the sediment interface. Exposure varied daily at times and increased through winter to values representing undiluted plume groundwater. Exposure to pelagic organisms (overlying water) covered a larger area (~50%) due to in-pond circulation. The stream outlet concentrations were stable at approximately 10 times dilution for chloride and saccharin, but were substantially less in summer for ammonium due to in-pond processes. Whereas groundwater contaminants are typically assumed elevated at base flows, the outlet stream contaminant mass discharges to downstream receptors were notably higher in winter than summer, following stream flow patterns. Insights from the present study into the timings and locations of contaminant plume exposure to multiple ecological zones of a pond can provide guidance to contaminated site and aquatic ecosystem managers on improved monitoring, assessment, and remediation protocols. Environ Toxicol Chem 2023;42:1667–1684. © 2023 His Majesty the King in Right of Canada and The Authors. Environmental Toxicology and Chemistry published by Wiley Periodicals LLC on behalf of SETAC. Reproduced with the permission of the Minister of Environment and Climate Change Canada.
Abstract
Discharge of the contaminants of a groundwater landfill plume to a pond leads to variable exposure across multiple ecological zones, with relative differences in the magnitude in concentrations and in the spatial extent and temporal stability of contamination.