bluuebunny/crossref_metadata_2025_split huggingface dataset:
On the axial chirality of leucoindigo
Authors: Pagola G. I. , Provasi P. F. , Ferraro M. B. , Lazzeretti P. 
Published: April 2023

AbstractThe diagonal components and the trace of two tensors which account for chiroptical response of the leucoindigo molecule that is, static anapole magnetizability, and dynamic electric dipole‐magnetic dipole polarisability depending on the frequency of impinging light, are a function of the dihedral angle of torsion about the central CC bond, assumed to lie in the direction of the coordinate system. They vanish for symmetry reasons at and , corresponding respectively to and point group symmetries, that is, cis and trans conformers characterized by the presence of molecular symmetry planes. Nonetheless, diagonal components and average value of static anapole polarizability and optical rotation tensors vanish at , where leucondigo is unquestionably chiral from the geometrical viewpoint. Vanishing values of the average chiroptical properties have been observed also in the proximity of other angles. Attempts have been made to explain the occurrence of accidental zeros of chiroptical properties in terms of transition frequencies and scalar products appearing in the numerator of their quantum mechanical definitions. Within the electric dipole approximation, the presence of anomalous vanishing values of tensor components of anapole magnetizability and electric‐magnetic dipole polarizability is ascribed to physical achirality, arising from the lack of either toroidal or spiral electron flow along the , and directions.
Reliable neck sonography of nodal thyroglobulin to diagnose recurrent/persistent disease from papillary thyroid carcinoma
Authors: Chen Yilai , Chen Yudong , Zhan Weiwei , Zhou Wei 
Published: April 2023

AbstractObjectiveThis study evaluates the correlation between the sonographic features and the nodal fine‐needle aspiration thyroglobulin (FNA‐Tg) in papillary thyroid carcinoma (PTC) patients with the recurrent/persistent lymph node for the purpose of the reasonable selection of lymph nodes.MethodsThis study prospectively contained PTC patients with the suspicious cervical lymph nodes in one medical center from April 2018 to January 2019. Each suspected lymph node was aspirated with a 22‐gauge needle and the value of FNA‐Tg was measured as well.ResultsThere were 136 lymph nodes related to the disease involved. The FNA‐Tg levels of 89 (65.44%) metastatic lymph nodes were significantly higher than those of the benign. The median value of the former was 631.550 ng/mL while the latter was 0.056 ng/mL (p = 0.000). The cut‐off value of the metastatic lymph nodes diagnosed by FNA‐Tg was 2.71 ng/mL, and 6.5 by FNA‐Tg/sTg. The suspicious ultrasonographic features including cystic, hyperechoic content, and lack of hilum were closely related to the high level of FNA‐Tg value (p < 0.05). However, the round shape (Solbiati index <2) and calcification were not significantly correlated with the positive FNA‐Tg (p > 0.05).ConclusionFNA‐Tg is an effective supplement to fine‐needle aspiration (FNA) cytology in the nodal metastasis diagnosis. The FNA‐Tg level was much higher in the metastatic lymph nodes. The reliable sonographic features of lymph nodes suggested the positive FNA‐Tg were cystic content, hyperechoic content and lack hilum. Solbiati index <2 and calcification did not show an exact correlation with the result of FNA‐Tg.
A phase 1 first‐in‐human study of GS‐0189, an anti‐signal regulatory protein alpha (SIRPα) monoclonal antibody, in patients with relapsed/refractory (R/R) non‐Hodgkin lymphoma (NHL)
Authors: Narkhede Mayur , Bartlett Nancy L. , Ibrahimi Sami , Popplewell Leslie , Seto Anna , Bates Jamie , Lee Yeonju , Ganti Vaishnavi , Han Ling , Chen Tianling , Patel Manish R. 
Published: April 2023

AbstractSignal regulatory protein alpha (SIRPα) is the receptor for cluster of differentiation (CD)47, a potent “don't eat me” signal for macrophages. Disruption of CD47‐SIRPα signaling in the presence of prophagocytic signals can lead to enhanced phagocytosis of tumor cells, resulting in a direct antitumor effect; agents targeting this pathway have shown efficacy in non‐Hodgkin lymphoma (NHL) and other tumor types. GS‐0189 is a novel anti‐SIRPα humanized monoclonal antibody. Here we report: (1) clinical safety, preliminary activity, and pharmacokinetics of GS‐0189 as monotherapy and in combination with rituximab from a phase 1 clinical trial in patients with relapsed/refractory NHL (NCT04502706, SRP001); (2) in vitro characterization of GS‐0189 binding to SIRPα; and (3) in vitro phagocytic activity. Clinically, GS‐0189 was well tolerated in patients with relapsed/refractory NHL with evidence of clinical activity in combination with rituximab. Receptor occupancy (RO) of GS‐0189 was highly variable in NHL patients; binding affinity studies showed significantly higher affinity for SIRPα variant 1 than variant 2, consistent with RO in patient and healthy donor samples. In vitro phagocytosis induced by GS‐0189 was also SIRPα variant–dependent. Although clinical development of GS‐0189 was discontinued, the CD47‐SIRPα signaling pathway remains a promising therapeutic target and should continue to be explored.
Porphyrin‐based ligand interaction with G‐quadruplex: Metal cation effects
Authors: Otovat Fahimeh , Bozorgmehr Mohammad Reza , Mahmoudi Ali , Morsali Ali 
Published: April 2023

AbstractThe G‐quadruplex planar‐ligand complex is used to detect heavy metal cations such as Ag+, Cu2+, Pb2+, Hg2+, organic molecules, nucleic acids, and proteins. The interaction of the three planar porphyrins (L1), 5,10,15,20‐tetrakis (1‐ethyl‐1‐λ4‐pyridine‐4‐yl) porphyrin (L2), and 5,10,15,20‐tetrakis (1‐methyl‐1‐λ4‐pyridine‐4‐yl) porphyrin (L3), coming from the porphyrin family, with G‐quadruplex obtained from human DNA telomeres in the presence of lithium, sodium, potassium, rubidium, cesium, magnesium, and calcium ions was studied by molecular dynamics simulation. When G‐quadruplex containing divalent ions of magnesium and calcium interacts with L1, L2, and L3 ligands, the hydrogen bonds of the lower G‐quadruplex sheet are more affected by ligands and the distance between guanines in the lower tetrad increases. In the case of G‐quadruplex interactions containing monovalent ions with ligands, the hydrogen bond between the sheets does not follow a specific trend. For example, in the presence of lithium ions, the upper and middle sheets are more affected by ligands, while they are less affected by ligands in the presence of sodium. The binding pocket and the binding energy of the three ligands to the G‐quadruplex were also obtained in the various systems. The results show that ligands make the G‐quadruplex more stable through the penetration between the sheets and the interaction with the loops. Among the ligands mentioned, the interaction level of the ligand L2 is greater than the others. Our calculations are consistent with the previous experimental observations so that it can help to understand the molecular mechanism of porphyrin interaction and its derivatives with the G‐quadruplex.
Influence of cantilever tip geometry and contact model on AFM elasticity measurement of cells
Authors: Kulkarni Shruti G. , Pérez‐Domínguez Sandra , Radmacher Manfred 
Published: April 2023

AbstractWe have measured the elastic properties of live cells by Atomic Force Microscope (AFM) using different tip geometries commonly used in AFM studies. Soft 4‐sided pyramidal probes (spring constant = 12 and 30 mN/m, radius 20 nm), 3‐sided pyramidal probes (spring constant = 100 mN/m, radius 65‐75 nm), flat (circular) probes (spring constant = 63 mN/m, radius 290 nm) and spherical probes (spring constant = 43 mN/m, radius 5 μm) have been used. Cells (3T3 fibroblasts) having elastic moduli around 0.5 kPa were investigated. We found that cell measured stiffness shows a systematic dependence on tip geometry: the sharper the tip, the higher the average modulus values. We hypothesize that the blunter the tip, the larger the contact area over which the mechanical response is measured or averaged. If there are small‐scale stiffer areas (like actin bundles) they will be easier to pick up by a sharp probe. This effect can be seen in the wider distribution of the histograms of the measured elastic moduli on cells. Furthermore, non‐linear responses of cells may be present due to the high average pressures applied by sharp probes, which would lead to an overestimation of the Young's modulus. Pressure versus contact radius simulations for the different tip geometries for a 0.5 kPa sample suggested similar average pressure for Bio‐MLCTs, PFQNM and cut tips, except spherical tips that showed much lower average pressure at the same 400 nm indentation. However, real data of the cells suggested different results. Using the same indentation depth (400 nm), PFQNM and Bio‐MLCTs showed similar average pressure and it decreased for cut and spherical tips. The calculated contact area at 400 nm cell indentation, using the obtained apparent Young's modulus for each tip geometry, showed the following distribution: Bio‐MLCTs < PFQNM < cut << spherical. In summary, tip geometry as well as average pressure and tip‐sample contact area are important parameters to take into account when measuring mechanical properties of soft samples. The larger the tip radius, the larger the contact area that will lead to a more evenly distribution of the applied pressure.
Techniques in the freedom‐from oppression model: An integrative existential‐cognitive therapy
Authors: Vickery Patrick J. , Hanna Fred J. , Wilkinson Brett D. 
Published: April 2023

AbstractThe freedom‐from oppression model is an integrative conceptual and practical framework for addressing the deleterious impact of oppression on clients. Applying multiculturally grounded counseling strategies as well as various techniques across three existential‐humanistic stages and 12 cognitive intervention steps, the proposed model supports counselor and client discovery of psychological freedom‐from oppression.
Rheological and quality properties of tiger nut containing biscuit dough baked inIR‐MWcombination oven
Authors: Çinar Azra Tuğçe , Turabi Yolaçaner Elif , Ateş Elif Gökçen 
Published: April 2023

AbstractBACKGROUNDThe effects of replacing part of the rice flour (RF) with tiger nut flour (TNF) were studied in gluten‐free biscuits. A control biscuit dough containing RF only and five formulations containing 10, 20, 30, 40, and 50% tiger nut flour on a flour basis (10TNF, 20TNF, 30TNF, 40TNF, and 50TNF) were prepared. The rheological and quality properties of biscuits baked both in conventional and infrared‐microwave combination (IR‐MW) ovens were determined.RESULTSThe rheological results showed that as theTNFratio increased, the storage modulus (G′), loss modulus (G″) and complex viscosity (ƞ*) decreased due to the high oil and dietary fiber content of theTNF. Texture analysis results showed that control dough and biscuits showed harder texture because of the damaged starch content ofRF. Damaged starch also affected the spread ratio of the biscuits adversely. Weight loss of the biscuits baked in theIR‐MWoven was higher than the ones baked in the conventional oven since higher inside pressure occurred in the dough. The color of the conventional baked biscuits was darker thanIR‐MWbaked ones due to the greater extent of Maillard browning. As theTNFratio increased, darker biscuits were obtained sinceTNFhas a high amount of sugar, and also its natural color is brown.CONCLUSIONGiven the excellent nutritional and product quality impacts of TNF, it would be appropriate to use it as a raw material substitute in gluten‐free biscuits. Furthermore, IR‐MW baking was shown to be an appropriate method for biscuit quality when compared to conventional baking. © 2023 Society of Chemical Industry.
Comparing carbon nanoparticles and indocyanine green for sentinel lymph node mapping in endometrial cancer: A randomized‐controlled single‐center trial
Authors: He Miao , Liang Sichen , Deng Hao , Zhang Guo , Wang Zhiqi , Yang Xin , Wang Yue , Li Yi , Sun Xiuli , Wang Jianliu 
Published: April 2023

AbstractBackground and ObjectivesTo compare the feasibility and diagnostic value of sentinel lymph node (SLN) mapping with carbon nanoparticles (CNPs) and indocyanine green (ICG) in endometrial cancer (EC).MethodsThis was a single‐center, open‐label, randomized controlled trial. Between August 1, 2020 and April 30, 2022, patients with early‐stage EC were assessed for enrollment. All patients underwent SLN mapping with ICG or CNPs ± pelvic and/or para‐aortic lymphadenectomy. The detection rate (DR), its impact factors, the sensitivity and the negative predictive value (NPV) of SLN mapping were analyzed.ResultsIn total, 206 patients, with 103 per group, were included. The overall and bilateral DRs of the two groups were comparable without significant differences. There was no difference regarding the distribution of mapped SLNs. The sensitivity was 66.7% for both groups, and the NPVs were not significantly different. Furthermore, the sensitivity and NPV reached 100% when calculated either per hemipelvis or only in patients with bilateral SLN detection.ConclusionsSLN mapping by CNPs in EC is feasible with high DRs and diagnostic accuracy compared with ICG. CNPs might be an alternative to ICG for SLN mapping when near‐infrared imaging equipment is lacking, especially in stage IA patients.
Does Medical School Rank Impact Matching into Otolaryngology?
Authors: DiNardo Lauren A. , Reese Alyssa D. , Powers Kristina F. , Siddiqui Afreen , Gupta Soumya , Carr Michele M. 
Published: April 2023

Objective(s)To describe how medical school rank may be associated with matriculation into otolaryngology residency programs.MethodsA list of medical students who matched into otolaryngology residencies in 2020, 2021, and 2022 was obtained from Otomatch (Otomatch.com). For each student, their medical school, U.S. News & World Report Best Medical School (Research) ranking, and region based on the U.S. Census divisions were recorded. The medical schools were divided into four Tiers according to rank: 1–40 (Tier 1), 41–80 (Tier 2), 81–124 (Tier 3), and 125–191 (Tier 4). Residency programs were also grouped by region, whether they were large (>3 residents/year) or small (<3 residents/year), and their Doximity reputation ranking: 1–31 (Tier 1), 32–61 (Tier 2), 62–91 (Tier 3), and 92–125 (Tier 4).ResultsNine hundred and ninety‐five medical students were included in this study. The majority of residency matriculants were MDs (N = 988, 99.3%) who came from Tier 1 (N = 410, 41.2%) or Tier 2 (N = 313, 31.5%) medical schools. Those who attended higher‐tier medical schools were more likely to match into higher‐tier residency programs (p < 0.001). 57.8% (N = 237) of the applicants who attended Tier 1 medical schools matriculated into a Tier 1 residency program, whereas only 24.7% (N = 42) of the applicants from Tier 4 medical schools matriculated into a Tier 1 residency program.ConclusionApplicants who attend top‐tier medical schools represent significantly more residents at top‐tier otolaryngology residency programs than those from lower tier medial schools.Level of EvidenceNA Laryngoscope, 133:3353–3357, 2023
Drivers of rhizosphere microbial differences in desert genus Haloxylon
Authors: Wu Deyan , Jiang Lamei , Li Wenjing , Wu Qiong , Lv Guanghui 
Published: April 2023

AbstractRhizosphere is a powerful interface for interaction between soil, plants, and soil microorganisms. Little is known about the interactions between closely related species and their microbial communities in the desert. Using 16S rRNA and ITS high‐throughput sequencing methods, we studied the diversity of the rhizosphere and bulk soils microbial communities of the two species (Haloxylon ammodendron and Haloxylon persicum) at the edge of the Gurbantunggut Desert. Results showed that the diversity and composition of bacterial communities of these two species were significantly different, with bacteria and fungi explaining 53.54% and 35.40% of the total variation by principal coordinates analysis analysis. The Chao, Shannon, and Margalef index of the rhizosphere bacteria were significantly higher than those for the bulk bacteria(p < 0.05). The co‐occurrence network in rhizosphere soil were more complex than those in bulk soil, and bacteria were higher than that of fungi. Soil moisture, salinity, and nutrients significantly affected the diversity of the soil bacterial community (p < 0.05), but had no significant effects on the fungal community. The dissimilarity distance of bacterial community composition was significantly correlated with environmental distance (p < 0.05), and the most important environmental factor was available nutrients in the soil, which drove the soil microbial community composition and diversity. The composition and diversity of the bacteria in desert soil were affected by plant species and soil types, and differences among closely related species. These findings can enhance knowledge of the associations between closely related species and soil microorganisms, and contribute to the control of desertification.
Linker Exchange as Facile Method for Post‐Synthetic Modification of β‐Ketoenamine‐linked Covalent Organic Frameworks
Authors: Dippold Veit , Vogl Sarah , Grüneberg Julia , Thomas Arne 
Published: April 2023

AbstractPost‐synthetic linker exchange performed on covalent organic frameworks (COFs) has become an important method to introduce functional building blocks into their backbone and thus to tune their chemical and physical properties. However, the linker exchange method has so far only been described for COFs with relatively weak linkages like imines. Herein, it is shown that this method can be also used for a post‐synthetic linker exchange reaction on a β‐ketoenamine linked COF. The time needed to achieve considerable linker exchange is much prolonged compared to other COFs with less stable linkages, however, this enables to achieve very good control on the ratio of the respective building blocks within the framework.
Placement defects in thermoset‐impregnated rovings deposited along curved paths
Authors: Eckrich Maximilian , Arrabiyeh Peter A. , Dlugaj Anna M. , May David 
Published: April 2023

AbstractWet Fiber Placement (WFP) is a novel process for manufacturing complex shaped parts from continuous fiber‐reinforced polymers without semi‐finished products. Here, dry fiber bundles (rovings) are in‐line impregnated with a thermoset resin, followed by almost tension‐free deposition. The freshly impregnated and limp rovings allow for placement in radii. Due to the lack of compression in deposition, subsequent consolidation, for example, via vacuum bagging, is required. However, this consolidation cannot compensate for defects already present in the deposited lay‐up as they will typically occur when depositing rovings along curved paths. In this study, we deposited two carbon fiber rovings in radii between 5 and 2000 mm by WFP. The occurring defects were visually evaluated. Three main defects were observed: Fiber waviness, up‐folding and twists. The extent of the defects was evaluated using image analysis techniques. Results show, that up‐folding and twists are dominant for radii <100 mm, while for greater radii fiber waviness is the main defect. Up‐folding and twists almost completely disappear for radii >500 mm, but a slight waviness is still observed. However, the effect of fiber waviness on the longitudinal stiffness is estimated to be small for radii >500 mm and perhaps acceptable for some applications.
Soaking pretreatment of hydrogel adsorbent in distilled water to enhance efficiency of adsorption onto low concentration dye
Authors: Wang Wengang , Wu Qi , Wang Lei , Zhang Ming , Yu Bo , Li Xiaoning , Yan Han , Wan Li 
Published: April 2023

AbstractTo address the poor removal rate of low‐concentration dye adsorption, the soaking pretreatment of hydrogel adsorbent in distilled water was suggested. In contrast to the conventional method of directly adding dried particles into dye solution, the purposed procedure involved adding an adsorbent into distilled water before transferring it into the dye solution. A hydrogel adsorbent based on P(AANa/AM) containing COONa groups was fabricated as an example for the hypothesis. The maximum adsorption capacity of P(AANa/AM) hydrogel adsorbent onto MB was 2455.45 mg/g under an initial MB concentration of 1000 mg/L. After two rounds of soaking pretreatment in distilled water, the clearance rate of 20 mg/L MB increased from 97.79% to 99.40%. Considering the hydrophilicity and ionization of COONa group, a high concentration of Na+ was released into solution. Hydrogel soaked multiple times in fresh distilled water induced the continuous release of Na+ into distilled water, although the swelling equilibrium was already achieved in the first soak. In dye adsorption and desorption experiments, the water absorption behavior was observed. Overall, this work revealed that the soaking pretreatment of hydrogel adsorbent in distilled water can enhance the removal rate of low concentration dye through adsorption.
Heterogenization of nickel catalysts with ionic liquid‐modified supports for ethylene polymerization and copolymerization
Authors: Wang Quan , Sun Yao , Pan Yao , Pang Wenmin , Si Guifu , Zou Chen 
Published: April 2023

AbstractThe preparation of heterogeneous catalysts by loading homogeneous metal complexes on the supports is an effective strategy preferred by the polyolefin industry. In this contribution, we synthesize a series of heterogeneous nickel catalysts using the supporting strategy of ionic liquid‐modified supports. These supported catalysts have polymerization activities up to 1.68 × 107 g mol−1 h−1, polymer molecular weights up to 224.1 × 104 g mol−1, and significantly, higher melting points compared to homogeneous systems. The polyolefin materials prepared by this supporting strategy possess a wide range of tunable mechanical properties, from thermoplastics to elastomers. These heterogeneous nickel catalysts can catalyze the copolymerization of ethylene and methyl 10‐undecenoate.
Supramolecular polymers: Dynamic assemblies of “dancing” monomers
Authors: Pavlović Radoslav Z. , Egner Simon A. , Palmer Liam C. , Stupp Samuel I. 
Published: April 2023

AbstractThe objective of this perspective on supramolecular polymers is to highlight how their dynamic nature based on noncovalent bonding among monomers can have a profound impact on their functions. We focus here on peptide amphiphile supramolecular polymers developed in our laboratory and use recent results on their dynamic behavior to reflect on the exciting functions that might emerge in these systems. We are greatly motivated by recent results that demonstrate unprecedented bioactivity in supramolecular polymers to address the enormous scientific challenge of finding strategies to reverse paralysis caused by traumatic injuries or disease. We suggest that future opportunities exist for novel functions in supramolecular polymers by tuning dynamic behavior through the chemical design of monomers, and also by gaining an understanding of the precise spatiotemporal mechanisms linked to supramolecular motion in these emerging polymers.