bluuebunny/crossref_metadata_2025_split huggingface dataset:
Overall Survival With Daratumumab, Lenalidomide, and Dexamethasone in Previously Treated Multiple Myeloma (POLLUX): A Randomized, Open-Label, Phase III Trial
Authors: Dimopoulos Meletios A. , Oriol Albert , Nahi Hareth , San-Miguel Jesus , Bahlis Nizar J. , Usmani Saad Z. , Rabin Neil , Orlowski Robert Z. , Suzuki Kenshi , Plesner Torben , Yoon Sung-Soo , Ben Yehuda Dina , Richardson Paul G. , Goldschmidt Hartmut , Reece Donna , Ahmadi Tahamtan , Qin Xiang , Garvin Mayo Wendy , Gai Xue , Carey Jodi , Carson Robin , Moreau Philippe 
Published: January 2023

PURPOSE With the initial analysis of POLLUX at a median follow-up of 13.5 months, daratumumab in combination with lenalidomide and dexamethasone (D-Rd) significantly prolonged progression-free survival versus lenalidomide and dexamethasone (Rd) alone in patients with relapsed or refractory multiple myeloma (RRMM). We report updated efficacy and safety results at the time of final analysis for overall survival (OS). METHODS POLLUX was a multicenter, randomized, open-label, phase III study during which eligible patients with ≥ 1 line of prior therapy were randomly assigned 1:1 to D-Rd or Rd until disease progression or unacceptable toxicity. After positive primary analysis and protocol amendment, patients receiving Rd were offered daratumumab monotherapy after disease progression. RESULTS Significant OS benefit was observed with D-Rd (hazard ratio, 0.73; 95% CI, 0.58 to 0.91; P = .0044) at a median (range) follow-up of 79.7 months (0.0-86.5). The median OS was 67.6 months for D-Rd compared with 51.8 months for Rd. Prespecified analyses demonstrated an improved OS with D-Rd versus Rd in most subgroups, including patients age ≥ 65 years and patients with one, two, or three prior lines of therapy, International Staging System stage III disease, high-risk cytogenetic abnormalities, and refractoriness to their last prior line of therapy or a proteasome inhibitor. The most common (≥ 10%) grade 3/4 treatment-emergent adverse events with D-Rd versus Rd were neutropenia (57.6% v 41.6%), anemia (19.8% v 22.4%), pneumonia (17.3% v 11.0%), thrombocytopenia (15.5% v 15.7%), and diarrhea (10.2% v 3.9%). CONCLUSION D-Rd significantly extended OS versus Rd alone in patients with RRMM. To our knowledge, for the first time, our findings, together with the OS benefit observed with daratumumab plus bortezomib and dexamethasone in the phase III CASTOR trial, demonstrate OS improvement with daratumumab-containing regimens in RRMM (ClinicalTrials.gov identifier: NCT02076009 [POLLUX]).
Detection of SARS-CoV-2 in conjunctival secretion and tears in patients with COVID-19 in a tertiary care centre, South India. .
Authors: R. Nayak Rajesh , Bhat Sevitha , R Kamath Ajay , Chandak Anshul , Khare Kanishk 
Published: January 2023

Aims and objectives: Purpose of this study is to detect the presence of SAR-CoV-2 viral RNA in conjunctival secretions of COVID-19 patients and to compare the RT-PCR positivity rate for SARS-CoV-2 in conjunctival and nasopharyngeal swab. Materials and method: Eighty hospitalised COVID-19 patients whose nasopharyngeal swab tested positive for SARS-CoV-2 by RT-PCR were included in the study. Conjunctival swab was collected from eyes of these patients and sent for detection of SARS-CoV-2 by RT-PCR method. Results: Among the eighty patients, 51 (63.7%) were males and 29 (36.3%) were females. The mean age of the patients was 55.93 ± 16.59. Six patients had ocular manifestations. Eleven (13.75%) patients tested positive on conjunctival swab for SARS-CoV-2 viral RNA and only one of them had ocular manifestations out of the eleven. Conclusion: In our study the presence of SARS-CoV-2 in conjunctival secretions of COVID-19 patients was detected and this was not dependent on presence of ocular manifestations or duration of disease. Though the conjunctival positivity is lower compared to the nasopharyngeal swab sampling, ocular surface and secretions can be a potential route of viral transmission.
Algorithm for Robotic Picking in Amazon Fulfillment Centers Enables Humans and Robots to Work Together Effectively
Authors: Allgor Russell , Cezik Tolga , Chen Daniel 
Published: January 2023

This paper describes how Amazon redesigned the robotic picking algorithm used in Amazon Robotics (AR) fulfillment centers (FCs) to enable humans and robots to work together effectively. In AR FCs, robotic drives fetch storage pods filled with inventory for associates to pick. The picking algorithm needs to decide which specific units of inventory on which pods should be picked to fulfill customer order shipments. We want to do so in a way that is most efficient and distance traveled by drives per unit picked is the key performance metric. This new algorithm reduced the distance traveled by drives per unit picked by 62% without negative operational impact and has since been implemented in all AR FCs. This improvement reduced the number of drives required in AR FCs by 31%, which amounted to half a billion dollars in savings. The redesigned algorithm enabled seamless collaboration between associates and robots, and its effectiveness in scaling up convinced Amazon to make AR FCs the standard for new FCs, allowing Amazon to reduce the storage footprint by about 29% compared with non-AR FCs. History: This paper was refereed.
Measuring the Factors Influencing Purchasing Decisions: Evidence From Cursor Tracking and Cognitive Modeling
Authors: Fisher Geoffrey 
Published: January 2023

Whether to purchase a product is of fundamental importance to marketing, but purchasing behaviors vary widely across individuals and contexts. This paper proposes that a sizeable fraction of this variation is associated with differences in the time at which a product’s desirability and its price are processed and utilized by consumers. To test this hypothesis, participants purchased different products while their mouse cursor movements associated with purchasing an option were recorded across three laboratory studies. These natural cursor movements and estimates from a cognitive model identified the time at which product desirability and price each began to influence decisions. On average, we found that product desirability impacted the decision-making process significantly earlier than price. Moreover, the difference in the time at which product and price influenced choice explained a sizeable fraction of the variation in the option that was purchased. Additional analysis and studies revealed that the time at which an attribute begins to influence decisions can be altered by simple marketing actions, such as a product’s visual display and price discount framing, and that these actions have consequences for choice. Together, these results add to our understanding of how consumers make simple purchasing decisions. This paper was accepted by Matthew Shum, marketing. Funding: This work was supported by the Foundation for Food and Agriculture Research. Supplemental Material: The e-companion and data are available at https://doi.org/10.1287/mnsc.2022.4598 .
Job satisfaction among NHS and private orthotists: a cross-sectional comparative study
Authors: Prosser Katie , Achour Nebil 
Published: January 2023

Background/Aims The orthotic profession is facing a national staff shortage, which has been compounded by high attrition rates. Overall, 70% of NHS orthotic services in the UK are subcontracted out to private companies, but there has been little investigation of how this has affected job satisfaction and intention to remain in the profession among orthotists. This study evaluated and compared job satisfaction among orthotists employed by the NHS and private organisations. Methods A mixed-methods, cross-sectional comparative study was conducted. A total of 123 orthotists (36 employed by the NHS, 82 employed privately) completed an online questionnaire comprising 32 questions regarding their working conditions and job satisfaction, with a combination of free-text and 5-point Likert scale formats. Quantitative analysis was performed using the Statistical Package for Social Sciences (version 24), with P≤0.05 indicating significance. Results Over a third (37.4%, n=46) of respondents indicated that they would leave the orthotic profession if they could. The strongest predicting variable for intent to leave was how well staff felt that they were treated by their employer. Respondents consistently reported that their working environments were poor, but this was worse for those who were privately employed. Overall job satisfaction was low in both groups. Conclusions The orthotic profession may be facing a staff retention crisis. Employers should focus on improving working environments and ensuring that staff feel appreciated. Further research is required to investigate the impact of these issues on patient care.
Iliopsoas tendonitis after total hip arthroplasty
Authors: Hardwick-Morris Max , Twiggs Joshua , Miles Brad , Al-Dirini Rami M. A. , Taylor Mark , Balakumar Jitendra , Walter William L. 
Published: January 2023

Aims Iliopsoas impingement occurs in 4% to 30% of patients after undergoing total hip arthroplasty (THA). Despite a relatively high incidence, there are few attempts at modelling impingement between the iliopsoas and acetabular component, and no attempts at modelling this in a representative cohort of subjects. The purpose of this study was to develop a novel computational model for quantifying the impingement between the iliopsoas and acetabular component and validate its utility in a case-controlled investigation. Methods This was a retrospective cohort study of patients who underwent THA surgery that included 23 symptomatic patients diagnosed with iliopsoas tendonitis, and 23 patients not diagnosed with iliopsoas tendonitis. All patients received postoperative CT imaging, postoperative standing radiography, and had minimum six months’ follow-up. 3D models of each patient’s prosthetic and bony anatomy were generated, landmarked, and simulated in a novel iliopsoas impingement detection model in supine and standing pelvic positions. Logistic regression models were implemented to determine if the probability of pain could be significantly predicted. Receiver operating characteristic curves were generated to determine the model’s sensitivity, specificity, and area under the curve (AUC). Results Highly significant differences between the symptomatic and asymptomatic cohorts were observed for iliopsoas impingement. Logistic regression models determined that the impingement values significantly predicted the probability of groin pain. The simulation had a sensitivity of 74%, specificity of 100%, and an AUC of 0.86. Conclusion We developed a computational model that can quantify iliopsoas impingement and verified its accuracy in a case-controlled investigation. This tool has the potential to be used preoperatively, to guide decisions about optimal cup placement, and postoperatively, to assist in the diagnosis of iliopsoas tendonitis. Cite this article: Bone Jt Open 2023;4(1):3–12.
Multifunctional and tunable ultra-broadband linear to circle polarization converter based on VO2-integrated material
Authors: Qiao Zhen , Cao Rujia , Liao Siyuan , Zhang Haifeng 
Published: January 2023

Considering that the metastructures (MSs) previously proposed usually perform in a single state, herein, a multifunctional and tunable ultra-broadband linear to circle (LTC) polarization converter based on phase transition material vanadium dioxide (

V
O

2

) is proposed in the terahertz (THz) region. By manipulating the temperature, the function of the LTC polarization conversion (PC) can be conveniently switched between transmission and reflection states. When the environment temperature is low,

V
O

2

presents the insulating state, and the MS can achieve ultra-wideband LTC PC from 0.57–0.83 THz with a relative bandwidth (RB) of 37.3%. When the temperature exceeds 68°C, LTC PC with the frequency bandwidth of 0.83–1.20 THz and 0.83–1.17 THz can be obtained in a reflection state when electromagnetic waves propagate forward and backward, whose RBs are 36.4% and 34.0%, respectively. Meanwhile, a broadband linear to linear (LTL) PC can also be realized in the range of 1.19–1.41 THz for the forward incident wave and 1.16–1.37 THz for the backward incident wave. The designed MS offers an effective method to realize four different functions and has tremendous potential value in realizing THz modulation devices, electromagnetic cloaking, and communication systems.
Association between abdominal obesity and diabetic retinopathy in patients with diabetes mellitus: A systematic review and meta-analysis
Authors: Fu Shouqiang , Zhang Liwei , Xu Jing , Liu Ximing , Zhu Xiaoyun 
Published: January 2023

Objective
Previous studies have reported different opinions regarding the association between abdominal obesity and diabetic retinopathy (DR) in patients with diabetes mellitus (DM). In this study, we aimed to investigate this problem through a systematic review and meta-analysis to provide a basis for clinical interventions.

Methods
A comprehensive search was conducted in the PubMed, Embase, and Web of Science databases up to May 1, 2022, for all eligible observational studies. Standardized mean differences (SMD) and 95% confidence intervals (CI) were evaluated using a random-effects model in the Stata software. We then conducted, publication bias assessment, heterogeneity, subgroup and sensitivity analyses.

Results
A total of 5596 DR patients and 17907 non-DR patients were included from 24 studies. The results of the meta-analysis of abdominal obesity parameters showed statistically significant differences between DR and non-DR patients in both type 1 and type 2 diabetes. Waist circumference (WC) was higher in patients with DR than in the non-DR patients. In the waist-hip ratio (WHR) subgroup, the level of WHR was higher in patients with DR than that in non-DR patients. The association between abdominal obesity and mild to moderate nonproliferative DR or vision-threatening DR groups did not show any statistical difference. Subgroup analysis according to ethnicity showed that Caucasians had higher levels of combined abdominal obesity parameters than Asians.

Conclusion
We found that abdominal obesity measured by WC and WHR is associated with DR in patients with type 1 and type 2 diabetes. This association is stronger in Caucasians than in Asians, where isolated abdominal obesity might be more related to DR. However, no correlation was found between abdominal obesity and varying degrees of diabetic retinopathy. Further prospective cohort studies with larger sample sizes are yet to be conducted to clarify our findings.
Regression of Hepatic Fibrosis After Endoscopic Gastric Plication in Nonalcoholic Fatty Liver Disease
Authors: Jirapinyo Pichamol , Zucker Stephen D. , Thompson Christopher C. 
Published: January 2023

INTRODUCTION:
Fibrosis stage is the strongest predictor of mortality in patients with nonalcoholic fatty liver disease (NAFLD). There is currently no approved therapy that specifically targets fibrosis. This study aims to assess the effect of endoscopic gastric plication on hepatic fibrosis in patients with underlying NAFLD.

METHODS:
This is a retrospective analysis of prospectively collected registry of patients with obesity and NAFLD with clinically significant hepatic fibrosis (≥F2) who underwent endoscopic gastric plication. Full-thickness plications were placed in the gastric body using a commercially available platform to reduce the gastric volume. The primary outcome included various noninvasive tests (NITs) of hepatic fibrosis based on clinical chemistry and/or imaging. The secondary outcomes included NITs of hepatic steatosis, other metabolic outcomes, including hemoglobin A1c, insulin resistance, and total weight loss (TWL), and adverse events.

RESULTS:
Forty-five patients (age 51 ± 13 years and body mass index 40.7 ± 6.9 kg/m2) were included. All patients underwent endoscopic gastric plication successfully. At 6–12 months, there were significant reductions in biochemistries (alanine aminotransferase: 49.7 ± 36.8 U/L to 24.2 ± 12.0 U/L [P < 0.0001], aspartate aminotransferase: 39.1 ± 24.1 U/L to 24.1 ± 10.0 U/L [P < 0.0001]), composite fibrosis score (NAFLD fibrosis score: 0.48 ± 1.51 to −1.18 ± 1.56 [P < 0.0001], fibrosis-4 index: 1.4 ± 1.2 to 1.2 ± 0.7 [P = 0.03]), and imaging-based markers of fibrosis (vibration-controlled transient elastography: 13.9 ± 7.5 kPa to 8.9 ± 4.8 kPa (P < 0.0001) and Agile 3+: 0.53 ± 0.28 to 0.37 ± 0.28 [P = 0.001]). There were significant reductions in controlled attenuation parameter, Homeostatic Model Assessment for Insulin Resistance, and hemoglobin A1c (P < 0.05 for all). At 12 months, patients experienced 15.5% ± 7.9% TWL, with 63% reaching at least 10% TWL.

DISCUSSION:
Endoscopic gastric plication seems effective at treating NAFLD, with significant reduction in NITs of hepatic fibrosis even in patients with cirrhosis.
Prevalence of Celiac Disease in Patients With Liver Diseases: A Systematic Review and Meta-Analyses
Authors: Yoosuf Shakira , Singh Prashant , Khaitan Ashank , Strand Tor A. , Ahuja Vineet , Makharia Govind K. 
Published: January 2023

INTRODUCTION:
A subset of patients with celiac disease (CeD) has liver involvement in the form of hypertransaminasemia, liver cirrhosis, and autoimmune hepatitis. We conducted a systematic review with meta-analyses to determine the pooled prevalence of CeD in patients with cryptogenic cirrhosis, all-cause cirrhosis, cryptogenic hypertransaminasemia, and all-cause hypertransaminasemia.

METHODS:
We searched PubMed and EMBASE up to January 2022. Cross-sectional, case-control, and prospective cohort studies performing serological tests and/or intestinal biopsy for CeD on patients with cryptogenic cirrhosis, all-cause cirrhosis, cryptogenic hypertransaminasemia, and all-cause hypertransaminasemia were included to calculate pooled estimates of seroprevalence and the prevalence of biopsy-confirmed CeD in these 4 groups.

RESULTS:
Of 6,871 articles screened, 20 articles were included finally in 3 meta-analyses for cryptogenic cirrhosis, all-cause cirrhosis, and cryptogenic hypertransaminasemia. For the all-cause hypertransaminasemia group, a qualitative review of 4 studies was conducted instead of a meta-analysis due to significant differences in studies. The pooled prevalence (95% confidence interval) of biopsy-confirmed CeD in cryptogenic cirrhosis was 4.6% (2.2%–7.5%) while the pooled prevalence of biopsy-confirmed CeD in all-cause cirrhosis was 0.8% (0%–3.4%). The pooled prevalence of biopsy-confirmed CeD in cryptogenic hypertransaminasemia was 5.7% (3.2%–8.8%).

DISCUSSION:
Nearly 1 in 20 patients each with cryptogenic cirrhosis and cryptogenic hypertransaminasemia have CeD; hence, they should both be considered high-risk groups for CeD. While the prevalence of CeD in those with all-cause cirrhosis is similar to that in general population, it may be worth screening them for CeD because liver pathology has the potential for reversal in them.
Randomized Trial of Tenofovir With or Without Peginterferon Alfa Followed by Protocolized Treatment Withdrawal in Adults With Chronic Hepatitis B
Authors: Terrault Norah A. , Lok Anna S. , Wahed Abdus S. , Ghany Marc G. , Perrillo Robert P. , Fried Michael W. , Wong David K. , Khalili Mandana , Lau Daryl T.Y. , Sterling Richard K. , Di Bisceglie Adrian M. , Lisker-Melman Mauricio , Cooper Stewart L. , Chung Ray T. , Patel Keyur , Roberts Lewis R. , Belle Steven H. , Janssen Harry L.A. ,   for the Hepatitis B Research Network
Published: January 2023

INTRODUCTION:
Hepatitis B surface antigen (HBsAg) loss is associated with improved long-term outcomes of patients with chronic hepatitis B but is infrequently achieved with current monotherapies. We assessed whether combination strategies that included treatment withdrawal enhanced HBsAg loss.

METHODS:
A randomized (1:1) trial of tenofovir disoproxil fumarate (TDF) for 192 weeks with or without peginterferon (PegIFN) alfa-2a for the first 24 weeks, followed by withdrawal of TDF at week 192 with 48 weeks of off-treatment follow-up to week 240. The primary end point was HBsAg loss at week 240.

RESULTS:
Of 201 participants (52% HBeAg positive, 12%/6% genotype A/A2, 7% cirrhosis) randomized to TDF + PegIFN (n = 102) or TDF alone (n = 99), 6 participants had lost HBsAg at the end of the treatment phase (week 192), 5 (5.3%) in the combination group, and 1 (1.0%) in the TDF alone group (P = 0.09). By week 240, 9 participants had cleared HBsAg, 5.3% in combination, and 4.1% in monotherapy arms (P = 0.73). HBsAg decline and loss occurred earlier with TDF + PegIFN than TDF, with a ≥1-logIU/mL qHBsAg decline by week 24 in 28% in TDF + PegIFN compared with 6% in TDF (P = 0.04). HBsAg loss occurred in 7 of 12 (58%) with hepatitis B virus subgenotype A2 (all HBeAg positive) compared with only 2 of 189 (1%) with other hepatitis B virus genotypes and in 8 of 93 (8.6%) HBeAg positive vs 1 of 87 (1.1%) HBeAg negative.

DISCUSSION:
PegIFN combined TDF followed by protocolized TDF withdrawal led to earlier but not higher percentages of HBsAg clearance. Pretreatment HBeAg positivity and subgenotype A2 were strongly associated with HBsAg clearance.
Role of Cholangioscopy in a Patient With Hepatolithiasis and Caroli Disease
Authors: Morales Ximena , Jiménez-Hermida Laura , Pérez Juan Manuel , Hernández-Cely Geovanny 
Published: January 2023

ABSTRACT
Caroli disease is an infrequent congenital pathology that is part of the spectrum of fibrocystic diseases, characterized mainly by malformation of bile ducts. These patients often have stones and cholangitis, which respond poorly to conventional endoscopic retrograde cholangiopancreatography. To date, there is little evidence on the usefulness of cholangioscopy in this disease, so we describe the experience of performing cholangioscopy in a patient with hepatolithiasis and Caroli disease.
An Unusual Presentation of Segmental Arterial Mediolysis
Authors: Karna Rahul , Kaye Dylan , Jagdish Balaji , Johnston Alexandra , Venkat Divya 
Published: January 2023

ABSTRACT
Segmental arterial mediolysis (SAM) is a rare nonatherosclerotic and noninflammatory disease that often affects medium to large-sized arteries. We report a case of SAM involving bilateral hepatic arteries in an elderly woman. Although her initial presentation mimicked vasculitis, the clinical course and imaging led to the diagnosis of SAM. She was treated with coil embolization and stenting of the involved hepatic vessel leading to dramatic clinical improvement. It should be differentiated from vasculitis because there is no role of steroids in the management of SAM.
Dedifferentiated Liposarcoma Presenting as Dysphagia and Weight Loss: Common Symptoms but an Uncommon Diagnosis
Authors: Pham Linhchi , Swanson Paul E. , Tomizawa Yutaka 
Published: January 2023

ABSTRACT
A 76-year-old woman was referred for 6 months of progressively worsening dysphagia and unintentional weight loss. An esophagogastroduodenoscopy demonstrated an area of extrinsic compression in the lower esophagus measuring 7 cm in greatest dimension. Contrast-enhanced computed tomography revealed a solid homogeneous mass in the lower middle/posterior mediastinum, laterally displacing the esophagus. Endoscopic ultrasound-guided fine-needle biopsy showed a hypocellular infiltrate of pleomorphic cells in a loose collagenous matrix. By immunohistochemistry, neoplastic cells were negative for epithelial, vascular, neural, and melanocytic markers. Fluorescent in situ hybridization detected MDM2 amplification, compatible with a diagnosis of dedifferentiated liposarcoma.