bluuebunny/crossref_metadata_2025_split huggingface dataset:
PERUBAHAN KOMPOSISI GIZI KERANG DARA (Anadara granosa) KARENA PROSES PEREBUSAN
Authors: Inthe Mita Gebriella , Rusli Arham , Rahmaniar Rahmaniar 
Published: May 2023

Kerang Dara (Anadara granosa) merupakan salah satu jenis kerang yang terdapat di pantai laut pada substrat lumpur berpasir. Kerang Dara adalah salah satu jenis kerang laut yang memiliki potensi dan nilai ekonomis yang tinggi untuk dikembangkan sebagai sumber protein dan mineral untuk memenuhi kebutuhan pangan masyarakat Indonesia. Penelitian ini bertjuan untuk menganalisis dari segi fisik dan kimia kerang Dara (Anadara granosa) yang dipasarkan di daerah Pinrang Sulawesi Selatan. Penelitian terdiri dari beberapa tahapan yaitu pertama pengambilan sampel, pengukuran morfometrik, dan uji komposisi kimia. Hasil penelitian memiliki berat tubuh rata rata 25,42 gram, berat daging 3,086 gram dan berat cangkang 22,34 gram. Panjang Cangkang kerang 4,5 cm, lebar 4 cm dengan ketebalan 2,21 cm. Nilai Kadar protein kerang dara sebesar 12,51% (segar) dan 11,48% (rebus), kadar air 77,73% (segar) dan 76,15%(rebus), kadar abu 3,78% (segar) dan 4,07% (rebus), kadar lemak 3,55%(segar) dan 3,09% (rebus), Kadar karbohidrat (by difference) sebesar 2,75% (segar) dan 5,21% (rebus).Kata Kunci: Anadara granosa, Kerang Dara, Perebusan
Exploring temporary urban interventions through user activities: a case study of Abdali Boulevard, Amman, Jordan
Authors: Sharif Ahlam Ammar 
Published: May 2023

Introduction: Urban studies have examined the potential of urban interventions to upgrade spaces. This is the focus of relational approaches that emphasize interactions between interventions and users. One approach, actor–network theory, views these interactions as temporary stabilized relational effects. Despite its usefulness in uncovering diverse interactions in urban spaces, the utilization of actor–network theory in unpacking these relations has been limited.Methods: This study utilized an actor–network theory-inspired ethnography in a temporary urban intervention in Abdali Boulevard, in Jordan, to bridge this gap. It relied on desk research, interviews, and site observations to explore the different intervention–user interactions.Results: The findings revealed various interactions and relational patterns occurring between interventions and their users through their presence and absence in space and time, where users attended to, engaged with, overlooked, bypassed, disturbed the intervention, or floated between different modes of interaction.Discussion: Unpacking these diverse interactions and relations provides a nuanced perspective on the effects of urban interventions on spaces. This would be useful for designers in developing new ways of designing through offering interventions that engage the public.
Cartilage regeneration in zebrafish depends on Nrg1/ErbB signaling pathway
Authors: Sapède Dora , Bahraoui Sarah , Abou Nassif Léa , Barthelaix Audrey , Mathieu Marc , Jorgensen Christian , Djouad Farida 
Published: May 2023

Objective: Cartilage, as the majority of adult mammalian tissues, has limited regeneration capacity. Cartilage degradation consecutive to joint injury or aging then leads to irreversible joint damage and diseases. In contrast, several vertebrate species such as the zebrafish have the remarkable capacity to spontaneously regenerate skeletal structures after severe injuries. The objective of our study was to test the regenerative capacity of Meckel’s cartilage (MC) upon mechanical injury in zebrafish and to identify the mechanisms underlying this process.Methods and Results: Cartilage regenerative capacity in zebrafish larvae was investigated after mechanical injuries of the lower jaw MC in TgBAC(col2a1a:mCherry), to visualize the loss and recovery of cartilage. Confocal analysis revealed the formation of new chondrocytes and complete regeneration of MC at 14 days post-injury (dpi) via chondrocyte cell cycle re-entry and proliferation of pre-existing MC chondrocytes near the wound. Through expression analyses, we showed an increase of nrg1 expression in the regenerating lower jaw, which also expresses Nrg1 receptors, ErbB3 and ErbB2. Pharmacological inhibition of the ErbB pathway and specific knockdown of Nrg1 affected MC regeneration indicating the pivotal role of this pathway for cartilage regeneration. Finally, addition of exogenous NRG1 in an in vitro model of osteoarthritic (OA)-like chondrocytes induced by IL1β suggests that Nrg1/ErbB pathway is functional in mammalian chondrocytes and alleviates the increased expression of catabolic markers characteristic of OA-like chondrocytes.Conclusion: Our results show that the Nrg1/ErbB pathway is required for spontaneous cartilage regeneration in zebrafish and is of interest to design new therapeutic approaches to promote cartilage regeneration in mammals.
Gender-specific effects of oxidative balance score on the prevalence of diabetes in the US population from NHANES
Authors: Wu Cuiling , Ren Chenxia , Song Yingda , Gao Huifang , Pang Xin , Zhang Lianyun 
Published: May 2023

BackgroundThe relationship between oxidative balance score (OBS) and diabetes remains poorly understood and may be gender-specific. We conducted a cross-sectional study to investigate the complex association between OBS and diabetes among US adults.MethodsOverall, 5,233 participants were included in this cross-sectional study. The exposure variable was OBS, composed of scores for 20 dietary and lifestyle factors. Multivariable logistic regression, subgroup analysis, and restricted cubic spline (RCS) regression were applied to examine the relationship between OBS and diabetes.ResultsCompared to the lowest OBS quartile group (Q1), the multivariable-adjusted odds ratio (OR) (95% confidence interval (CI) for the highest OBS quartile group (Q4) was 0.602 (0.372–0.974) (p for trend = 0.007), and for the highest lifestyle, the OBS quartile group was 0.386 (0.223–0.667) (p for trend &lt; 0.001). Moreover, gender effects were found between OBS and diabetes (p for interaction = 0.044). RCS showed an inverted-U relationship between OBS and diabetes in women (p for non-linear = 6e−04) and a linear relationship between OBS and diabetes in men.ConclusionsIn summary, high OBS was negatively associated with diabetes risk in a gender-dependent manner.
Multi-scale and cross-dimensional TMS mapping: A proof of principle in patients with Parkinson’s disease and deep brain stimulation
Authors: Passera Brice , Harquel Sylvain , Chauvin Alan , Gérard Pauline , Lai Lisa , Moro Elena , Meoni Sara , Fraix Valerie , David Olivier , Raffin Estelle 
Published: May 2023

IntroductionTranscranial magnetic stimulation (TMS) mapping has become a critical tool for exploratory studies of the human corticomotor (M1) organization. Here, we propose to gather existing cutting-edge TMS-EMG and TMS-EEG approaches into a combined multi-dimensional TMS mapping that considers local and whole-brain excitability changes as well as state and time-specific changes in cortical activity. We applied this multi-dimensional TMS mapping approach to patients with Parkinson’s disease (PD) with Deep brain stimulation (DBS) of the sub-thalamic nucleus (STN) ON and OFF. Our goal was to identifying one or several TMS mapping-derived markers that could provide unprecedent new insights onto the mechanisms of DBS in movement disorders.MethodsSix PD patients (1 female, mean age: 62.5 yo [59–65]) implanted with DBS-STN for 1 year, underwent a robotized sulcus-shaped TMS motor mapping to measure changes in muscle-specific corticomotor representations and a movement initiation task to probe state-dependent modulations of corticospinal excitability in the ON (using clinically relevant DBS parameters) and OFF DBS states. Cortical excitability and evoked dynamics of three cortical areas involved in the neural control of voluntary movements (M1, pre-supplementary motor area – preSMA and inferior frontal gyrus – IFG) were then mapped using TMS-EEG coupling in the ON and OFF state. Lastly, we investigated the timing and nature of the STN-to-M1 inputs using a paired pulse DBS-TMS-EEG protocol.ResultsIn our sample of patients, DBS appeared to induce fast within-area somatotopic re-arrangements of motor finger representations in M1, as revealed by mediolateral shifts of corticomuscle representations. STN-DBS improved reaction times while up-regulating corticospinal excitability, especially during endogenous motor preparation. Evoked dynamics revealed marked increases in inhibitory circuits in the IFG and M1 with DBS ON. Finally, inhibitory conditioning effects of STN single pulses on corticomotor activity were found at timings relevant for the activation of inhibitory GABAergic receptors (4 and 20 ms).ConclusionTaken together, these results suggest a predominant role of some markers in explaining beneficial DBS effects, such as a context-dependent modulation of corticospinal excitability and the recruitment of distinct inhibitory circuits, involving long-range projections from higher level motor centers and local GABAergic neuronal populations. These combined measures might help to identify discriminative features of DBS mechanisms towards deep clinical phenotyping of DBS effects in Parkinson’s Disease and in other pathological conditions.
The acute adaptation of skin microcirculatory perfusion in vivo does not involve a local response but rather a centrally mediated adaptive reflex
Authors: Monteiro Rodrigues Luís , Rocha Clemente , Andrade Sérgio , Granja Tiago , Gregório João 
Published: May 2023

Introduction: Cardiovascular homeostasis involves the interaction of multiple players to ensure a permanent adaptation to each organ’s needs. Our previous research suggested that changes in skin microcirculation—even if slight and distal—always evoke an immediate global rather than “local” response affecting hemodynamic homeostasis. These observations question our understanding of known reflexes used to explore vascular physiology, such as reactive hyperemia and the venoarteriolar reflex (VAR). Thus, our study was designed to further explore these responses in older healthy adults of both sexes and to potentially provide objective evidence of a centrally mediated mechanism governing each of these adaptive processes.Methods: Participants (n = 22, 52.5 ± 6.2 years old) of both sexes were previously selected. Perfusion was recorded in both feet by laser Doppler flowmetry (LDF) and photoplethysmography (PPG). Two different maneuvers with opposite impacts on perfusion were applied as challengers to single limb reactive hyperemia evoked by massage and a single leg pending to generate a VAR. Measurements were taken at baseline (Phase I), during challenge (Phase II), and recovery (Phase III). A 95% confidence level was adopted. As proof of concept, six additional young healthy women were selected to provide video imaging by using optoacoustic tomography (OAT) of suprasystolic post-occlusive reactive hyperemia (PORH) in the upper limb.Results: Modified perfusion was detected by LDF and PPG in both limbs with both hyperemia and VAR, with clear systemic hemodynamic changes in all participants. Comparison with data obtained under the same conditions in a younger cohort, previously published by our group, revealed that results were not statistically different between the groups.Discussion: The OAT documentary and analysis showed that the suprasystolic pressure in the arm changed vasomotion in the forearm, displacing blood from the superficial to the deeper plexus vessels. Deflation allowed the blood to return and to be distributed in both plexuses. These responses were present in all individuals independent of their age. They appeared to be determined by the need to re-establish hemodynamics acutely modified by the challenger, which means that they were centrally mediated. Therefore, a new mechanistic interpretation of these exploratory maneuvers is required to better characterize in vivo cardiovascular physiology in humans.
Non-violent resistance parental training versus treatment as usual for children and adolescents with severe tyrannical behavior: a randomized controlled trial
Authors: Fongaro Erica , Aouinti Safa , Picot Marie-Christine , Pupier Florence , Omer Haim , Franc Nathalie , Purper-Ouakil Diane 
Published: May 2023

ObjectiveThis single-blinded, randomized, parallel group superiority trial evaluates whether the Non-Violent Resistance (NVR) program, a 10-session parental-group intervention, was more effective in reducing stress in parents of children aged 6–20 years and displaying severe tyrannical behavior (STB) compared to a treatment as usual (TAU) intervention that provided supportive counseling and psychoeducation.MethodsEighty two parents of youth aged 6–20 years with STB were enrolled by the Child and Adolescent Psychiatry Department at the University Hospital of Montpellier (France). A random block and stratified by age (6–12 and 13–20 years) randomization, was performed. All participants were interviewed by independent, blinded to group assignments, research assistants, and completed their assessments at baseline and treatment completion (4 months from baseline). Since this program has not been previously evaluated in this population, the study primarily evaluated the efficacy, using the Parenting Stress Index/Short Form (PSI-SF). The primary outcome was the change from baseline to treatment completion of the PSI-SF total score.ResultsSeventy three participants completed the study and were available for analysis (36 NVR and 37 TAU). At completion, between-groups comparison of the change (completion minus baseline) in the total score of PSI-SF was not significant (NVR: −4.3 (± 13.9); TAU: −7.6 (± 19.6); two-sample t-test p = 0.43; effect size of −0.19 [−0.67, 0.28]).ConclusionContrary to our expectation, NVR was not superior to TAU in reducing parental stress at completion for parents of children with STB. However, NVR showed positive outcomes in the follow-up, pointing to the importance to implement parental strategies and following this population over longer time periods in future projects.Clinical trial registration: Clinicaltrials.gov, identifier NCT05567276.
Unlocking asylum seekers’ voices: protocol of a mixed-method clinical study on the use of the cultural formulation interview with asylum seekers in Belgium
Authors: Claus Lukas , Schouler-Ocak Meryam , Braakman Mario H. , Sabbe Bernard , Van Beuren Godfried , van den Ameele Seline 
Published: May 2023

BackgroundDespite a high prevalence of mental disorders among asylum seekers, many barriers to mental healthcare exist. Cultural and contextual factors strongly influence the experience and expression of psychological distress, putting asylum seekers at greater risk of misdiagnosis and inappropriate treatment. The Cultural Formulation Interview (CFI) is a useful tool to map out cultural and contextual factors of mental disorders; however, to the best of our knowledge, it has not yet been investigated in asylum seekers specifically. The primary aim of this study is to evaluate the value of the CFI in the psychiatric assessment of asylum seekers. Second, we will describe the themes relevant to psychiatric distress in asylum seekers that are identified by the CFI. In addition, asylum seekers’ experience of the CFI will be evaluated.Methods and analysisThis cross-sectional, mixed-method clinical study aims to recruit a group of 60–80 asylum seekers (age 15–29) with mental health symptoms. Data will be collected using structured (MINI, PCL-5, HDRS-17, WHOQoL-BREF &amp; BSI) and semi-structured (CFI &amp; CFI-debriefing) questionnaires to assess cultural background, contextual factors, and illness severity. Multidisciplinary case discussions will be held after the completion of interviews, following a methodological stepped approach. Combining qualitative and quantitative research techniques, this study aims to generate reliable knowledge on working with the CFI in asylum seekers. Based on the findings, recommendations for clinicians will be developed.DiscussionThis study addresses the knowledge gap on using the CFI in asylum seekers. Compared to prior studies, it will provide new insights into the use of the CFI in the specific context of working with asylum seekers.Ethics and disseminationPrior research on the CFI in asylum seekers is limited, partly because of their high vulnerability and low access to care. The study protocol has been tailored in close collaboration with several stakeholders and validated after piloting. Ethical approval has already been obtained. Together with the stakeholders, the results will be translated into guidelines and training materials. Recommendations to policymakers will also be provided.
Relationship between birth weight and ambient temperature during pregnancy in a cross-sectional study of the residents of Suzhou, China
Authors: Ding Yi , Zhou Hui , Tong Min , Chen Xiaofang , Zhao Qian , Ma Yuqin , Wu Lei 
Published: May 2023

ObjectiveThe association between birth weight and ambient temperature during pregnancy remains inconclusive, and data from Chinese populations are scarce. We conducted a cross-sectional study to investigate the association between birth weight and ambient temperature during pregnancy among the residents of Suzhou Industrial Park, Suzhou, China.MethodsInformation regarding 10,903 infants born between January 2018 and December 2018 who were born at the hospitals in Suzhou Industrial Park, Jiangsu province was obtained via public birth records.ResultsThis study found that the ambient temperature during the first trimester of pregnancy was negatively correlated with birth weight, suggesting that elevated temperature may be related to lower birth weight. However, the ambient temperatures during the second and third trimesters of pregnancy were positively correlated with birth weight. Moreover, when the ambient temperature was below 15°C during the second trimester of pregnancy, the birth weight increased with temperature. However, when the temperature was higher than 15°C, the birth weight decreased with temperature. The relationship between ambient temperature in the third trimester and birth weight presented an inverted “U” curve. When the ambient temperature was lower than 20°C, the birth weight increased with ambient temperature, but when the ambient temperature was higher than 20°C, the increase of ambient temperature showed no significant relationship with the increase of birth weight.ConclusionThe ambient temperature was correlated with birth weight. The ambient temperature during the first trimester of pregnancy was negatively correlated with birth weight. The relationship between ambient temperature in the third trimester and birth weight presented an inverted “U” curve.
Knowledge, attitude, and practice of menstrual blood-derived mesenchymal stem cells among female healthcare workers in India
Authors: Kaur Karuna Nidhi , Nandi Dhruva , Ramachandran Krithika , Mohanan Lita , Subhashini S. , Segan Mehak , Tripathy Saswaty , Janardhanan Rajiv 
Published: May 2023

IntroductionMesenchymal stem cells (MSCs) are pluripotent progenitor cells that can be differentiated into a variety of specialized cell types. Menstrual blood, such as umbilical cord blood and bone marrow stem cells, is a rich source of MSCs with proliferative properties. This research was conducted to understand the knowledge, attitude, and practice of menstrual blood donation regarding menstrual blood-derived mesenchymal stem cells (MenSCs) among female healthcare workers in India.MethodologyA cross-sectional online and offline survey was conducted at the national level between 20 November 2021 and 10 March 2022. A self-constructed semi-structured questionnaire was distributed through Google Forms on various social media platforms. The questionnaire was self-administered, and data were collected using the purposive sampling technique.ResultsA total of 499 respondents completed the questionnaire. Nearly 49% of the respondents had adequate knowledge, 54% showed a positive attitude, and 45% reported adequate practices regarding menstrual blood donation and the usage of related products. The educational background, occupational status, and monthly income of the participants were found to be significantly associated with their attitude toward MenSCs.ConclusionThere is a need to promote interactive sessions on MenSCs among healthcare professionals in order to bridge the gap between general populations and the healthcare setting. Enhancing knowledge and awareness regarding the potential benefits of MenSCs would help in dissipating the age-old myths associated with menstruation and will benefit society as a whole.
Associations of psychological wellbeing with COVID-19 hospitalization and mortality in adults aged 50 years or older from 25 European countries and Israel
Authors: Wang Wenjun , Wang Jingjing , Shi Juanjuan , Li Yaping , Zhang Xin , Wu Fengping , Wang Yikai , Li Jia , Hao Miao , Liu Xiongtao , Zhai Song , Wang Yuan , Gao Ning , Tian Yan , Lu Rui , Yeo Yee Hui , Jia Xiaoli , Ji Fanpu , Dang Shuangsuo 
Published: May 2023

BackgroundLower psychological wellbeing is associated with poor outcomes in a variety of diseases and healthy populations. However, no study has investigated whether psychological wellbeing is associated with the outcomes of COVID-19. This study aimed to determine whether individuals with lower psychological wellbeing are more at risk for poor outcomes of COVID-19.MethodsData were from the Survey of Health, Aging, and Retirement in Europe (SHARE) in 2017 and SHARE's two COVID-19 surveys in June–September 2020 and June–August 2021. Psychological wellbeing was measured using the CASP-12 scale in 2017. The associations of the CASP-12 score with COVID-19 hospitalization and mortality were assessed using logistic models adjusted for age, sex, body mass index, smoking, physical activity, household income, education level, and chronic conditions. Sensitivity analyses were performed by imputing missing data or excluding cases whose diagnosis of COVID-19 was solely based on symptoms. A confirmatory analysis was conducted using data from the English Longitudinal Study of Aging (ELSA). Data analysis took place in October 2022.ResultsIn total, 3,886 individuals of 50 years of age or older with COVID-19 were included from 25 European countries and Israel, with 580 hospitalized (14.9%) and 100 deaths (2.6%). Compared with individuals in tertile 3 (highest) of the CASP-12 score, the adjusted odds ratios (ORs) of COVID-19 hospitalization were 1.81 (95% CI, 1.41–2.31) for those in tertile 1 (lowest) and 1.37 (95% CI, 1.07–1.75) for those in tertile 2. As for COVID-19 mortality, the adjusted ORs were 2.05 (95% CI, 1.12–3.77) for tertile 1 and 1.78 (95% CI, 0.98–3.23) for tertile 2, compared with tertile 3. The results were relatively robust to missing data or the exclusion of cases solely based on symptoms. This inverse association of the CASP-12 score with COVID-19 hospitalization risk was also observed in ELSA.ConclusionThis study shows that lower psychological wellbeing is independently associated with increased risks of COVID-19 hospitalization and mortality in European adults aged 50 years or older. Further study is needed to validate these associations in recent and future waves of the COVID-19 pandemic and other populations.