bluuebunny/crossref_metadata_2025_split huggingface dataset:
Whole‐brain DTI parameters associated with tau protein and hippocampal volume in Alzheimer's disease
Authors: Magalhães Thamires Naela Cardoso , Casseb Raphael Fernandes , Gerbelli Christian Luiz Baptista , Pimentel‐Siva Luciana Ramalho , Nogueira Mateus Henrique , Teixeira Camila Vieira Ligo , Carletti Ana Flávia Mac Knight , de Rezende Thiago Junqueira Ribeiro , Joaquim Helena Passarelli Giroud , Talib Leda Leme , Forlenza Orestes Vicente , Cendes Fernando , Balthazar Marcio Luiz Figueredo 
Published: January 2023

AbstractThe causes of the neurodegenerative processes in Alzheimer's disease (AD) are not completely known. Recent studies have shown that white matter (WM) damage could be more severe and widespread than whole‐brain cortical atrophy and that such damage may appear even before the damage to the gray matter (GM). In AD, Amyloid‐beta (Aβ42) and tau proteins could directly affect WM, spreading across brain networks. Since hippocampal atrophy is common in the early phase of disease, it is reasonable to expect that hippocampal volume (HV) might be also related to WM integrity. Our study aimed to evaluate the integrity of the whole‐brain WM, through diffusion tensor imaging (DTI) parameters, in mild AD and amnestic mild cognitive impairment (aMCI) due to AD (with Aβ42 alteration in cerebrospinal fluid [CSF]) in relation to controls; and possible correlations between those measures and the CSF levels of Aβ42, phosphorylated tau protein (p‐Tau) and total tau (t‐Tau). We found a widespread WM alteration in the groups, and we also observed correlations between p‐Tau and t‐Tau with tracts directly linked to mesial temporal lobe (MTL) structures (fornix and hippocampal cingulum). However, linear regressions showed that the HV better explained the variation found in the DTI measures (with weak to moderate effect sizes, explaining from 9% to 31%) than did CSF proteins. In conclusion, we found widespread alterations in WM integrity, particularly in regions commonly affected by the disease in our group of early‐stage disease and patients with Alzheimer's disease. Nonetheless, in the statistical models, the HV better predicted the integrity of the MTL tracts than the biomarkers in CSF.
Genetically engineered nano‐melittin vesicles for multimodal synergetic cancer therapy
Authors: Zhang Jianzhong , Liu Xue , Xia Yutian , Xu Shuyu , Liu Xuan , Xiao Haiqing , Wang Xiaoyong , Liu Chao , Liu Gang 
Published: January 2023

AbstractMelittin, the principal constituent in bee venom, is an attractive candidate for cancer therapy. However, its clinical applications are limited by hemolysis, nonspecific cytotoxicity, and rapid metabolism. Herein, a novel genetically engineered vesicular antibody‐melittin (VAM) drug delivery platform was proposed and validated for targeted cancer combination therapy. VAM generated from the cellular plasma membrane was bio‐synthetically fabricated, with the recombinant protein (hGC33 scFv‐melittin) being harbored and displayed on the cell membrane. The bioactive and targetable nanomelittin conjugated by hGC33 scFv could be released in an MMP14‐responsive manner at tumor sites, which reduced off‐target toxicity, especially the hemolytic activity of melittin. Importantly, VAM could be loaded with small‐molecule drugs or nanoparticles for combination therapy. Nanomelittin formed pores in membranes and disturbed phospholipid bilayers, which allowed the anticancer agents (i.e., chemotherapeutic drug doxorubicin and sonosensitizer purpurin 18 nanoparticles) co‐delivered by VAM to penetrate deeper tumor sites, leading to synergistic therapeutic effects. In particular, the punching effect generated by sonodynamic therapy further improved the immunomodulatory effect of nanomelittin to activate the immune response. Taken together, our findings indicate that clinically translatable VAM‐based strategies represent a universal, promising approach to multimodal synergetic cancer therapy.
Topographic localization of the sacroiliac joint and superior gluteal artery branches on the posterolateral ilium
Authors: Mahato Niladri Kumar 
Published: January 2023

AbstractLatrogenic vascular injuries at the posterior ilium during sacroiliac screw placements are not uncommon. Though intra‐operative imaging reduces the risk of such injuries, anatomical localization of the sacral segments using discrete topographical landmarks is not currently available. This descriptive study proposes the use of an anatomical grid system to localize the sacroiliac articulation on the posterolateral ilium. It also investigates the positional variability of the branches of the superior gluteal artery (SGA) within areas defined by the grid. 48 dried adult hip bones were examined to determine the position of the sacral articular surface on the posterolateral surface of the ilium. A novel grid‐system was defined and used to map the positions of the articulation of the first two sacral segments on the posterolateral ilium. Superficial and deep branches of the SGA were dissected in donor cadavers and their courses were virtually overlayed on the grid system. The grid system localized the sacral articular surfaces within a defined area on the posterior ilium. Arterial distributions indicated the presence of the superficial branch of SGA more frequently over the screw insertion area (at an intermuscular plane), while the deep branch ran closer to the ilium but antero‐inferior to the screw placement areas. This study proposes a new topographical perspective of visualizing SGA branches with respect to the cranial sacral segments. Precise localization of vascular anatomy may help to reduce potential risk of injury during sacroiliac screw placements.
METTL5 stabilizes c‐Myc by facilitating USP5 translation to reprogram glucose metabolism and promote hepatocellular carcinoma progression
Authors: Xia Peng , Zhang Hao , Lu Haofeng , Xu Kequan , Jiang Xiang , Jiang Yuke , Gongye Xiangdong , Chen Zhang , Liu Jie , Chen Xi , Ma Weijie , Zhang Zhonglin , Yuan Yufeng 
Published: January 2023

AbstractBackgroundHepatocellular carcinoma (HCC) is one of the most prevalent cancers in the world, with a high likelihood of metastasis and a dismal prognosis. The reprogramming of glucose metabolism is critical in the development of HCC. The Warburg effect has recently been confirmed to occur in a variety of cancers, including HCC. However, little is known about the molecular biological mechanisms underlying the Warburg effect in HCC cells. In this study, we sought to better understand how methyltransferase 5, N6‐adenosine (METTL5) controls the development of HCC and the Warburg effect.MethodsIn the current study, quantitative real‐time polymerase chain reaction and Western blotting were used to detect the expression of METTL5 in HCC tissues and cell lines. Several different cell models and animal models were established to determine the role of METTL5 in glucose metabolism reprogramming and the underlying molecular mechanism of HCC. Glutathione‐S‐transferase pulldown, coimmunoprecipitation, RNA sequencing, non‐targeted metabolomics, polysome profiling, and luciferase reporter assays were performed to investigate the molecular mechanisms of METTL5 in HCC cells.ResultsWe discovered that METTL5 drove glucose metabolic reprogramming to promote the proliferation and metastasis of HCC. Mechanistically, upregulation of METTL5 promoted c‐Myc stability and thus activated its downstream glycolytic genes lactate dehydrogenase A (LDHA), enolase 1 (ENO1), triosephosphate isomerase 1 (TPI1), solute carrier family 2 member 1 (SLC2A1), and pyruvate kinase M2 (PKM2). The c‐Box and ubiquitin binding domain (UBA) regions of ubiquitin specific peptidase 5 (USP5) binded to c‐Myc protein and inhibited K48‐linked polyubiquitination of c‐Myc. Further study revealed that METTL5 controled the USP5 translation process, which in turn regulated the ubiquitination of c‐Myc. Furthermore, we identified cAMP responsive element binding protein 1 (CREB1)/P300 as a critical transcriptional regulator of METTL5 that promoted the transcription of METTL5 in HCC. In patient‐derived tumor xenograft (PDX) models, adenovirus‐mediated knockout of METTL5 had a good antitumor effect and prolonged the survival of PDX‐bearing mice.ConclusionsThese findings point to a novel mechanism by which CREB1/P300‐METTL5‐USP5‐c‐Myc controls abnormal glucose metabolism and promotes tumor growth, suggesting that METTL5 is a potential therapeutic target and prognostic biomarker for HCC.
Electroporation Enhances the Anticancer Effects of Novel Cu(II) and Fe(II) Complexes in Chemotherapy‐Resistant Glioblastoma Cancer Cells
Authors: Alkis Mehmet Esref , Buldurun Kenan , Alan Yusuf , Turan Nevin , Altun Ayhan 
Published: January 2023

AbstractSchiff base ligand (L) was obtained by condensation reaction between 4‐aminopyrimidin‐2(1H)‐one (cytosine) with 2‐hydroxybenzaldehyde. The synthesized Schiff base was used for complexation with Cu(II) and Fe(II) ions used by a molar (2 : 1 mmol ration) in methanol solvent. The structural features of ligand, Cu(II), and Fe(II) metal complexes were determined by standard spectroscopic methods (FT‐IR, elemental analysis, proton and carbon NMR spectra, UV/VIS, and mass spectroscopy, magnetic susceptibility, thermal analysis, and powder X‐ray diffraction). The synthesized compounds (Schiff base and its metal complexes) were screened in terms of their anti‐proliferative activities in U118 and T98G human glioblastoma cell lines alone or in combination with electroporation (EP). Moreover, the human HDF (human dermal fibroblast) cell lines was used to check the bio‐compatibility of the compounds. Anti‐proliferative activities of all compounds were ascertained using an MTT assay. The complexes exhibited a good anti‐proliferative effect on U118 and T98G glioblastoma cell lines. In addition, these compounds had a negligible cytotoxic effect on the fibroblast HDF cell lines. The use of compounds in combination with EP significantly decreased the IC50 values compared to the use of compounds alone (p<0.05). These results show that newly synthesized Cu(II) and Fe(II) complexes can be developed for use in the treatment of chemotherapy‐resistant U118 and T98G glioblastoma cells and that treatment with lower doses can be provided when used in combination with EP.
Anion Modulated Expression of Chirality in Hydrogen Bond Templated Mechanically Chiral [2]Rotaxanes
Authors: Spicer Rebecca L. , Shearman Curtis C. , Evans Nicholas H. 
Published: January 2023

AbstractThe syntheses of two novel mechanically chiral rotaxanes containing urea and squaramide motifs (in yields of 33 % and 22 %, respectively) are presented. 1H NMR spectroscopic titrations reveal shuttling of the macrocycle – detectable by modulation of the expression of mechanical chirality in the NMR spectrum – is possible through the addition of achiral chloride anions, a process which is reversed by the addition of sodium cations.
Programmed Control of Fluorescence Blinking Patterns based on Electron Transfer in DNA
Authors: Fan Shuya , Takada Tadao , Maruyama Atsushi , Fujitsuka Mamoru , Kawai Kiyohiko 
Published: January 2023

AbstractFluorescence imaging uses changes in the fluorescence intensity and emission wavelength to analyze multiple targets simultaneously. To increase the number of targets that can be identified simultaneously, fluorescence blinking can be used as an additional parameter. To understand and eventually control blinking, we used DNA as a platform to elucidate the processes of electron transfer (ET) leading to blinking, down to the rate constants. With a fixed ET distance, various blinking patterns were observed depending on the DNA sequence between the donor and acceptor units of the DNA platform. The blinking pattern was successfully described with a combination of ET rate constants. Therefore, molecules with various blinking patterns can be developed by tuning ET. It is expected that the number of targets that can be analyzed simultaneously will increase by the power of the number of blinking patterns.
Enantioselective [3+2] Cycloaddition of Donor‐Acceptor Aziridines and Imines to Construct 2,5‐trans‐Imidazolidines
Authors: Qiao Jianglin , Wang Shiyu , Liu Xiaohua , Feng Xiaoming 
Published: January 2023

AbstractAn enantioselective [3+2] cycloaddition of donor‐acceptor aziridines with N‐aryl protected imines was developed with a Ni(ClO4)2 ⋅ 6H2O/N,N′‐dioxide catalyst system, providing a broad range of chiral trans‐substituted imidazolidine compounds with good yields and excellent enantioselectivities (up to 99 % yield, up to 98 % ee). Control experiments indicated that the products could offer excellent diastereoselectivities with the control of chiral Ni(II)‐N,N′‐dioxide complex and the interaction of the substrates. The possible catalytic process was proposed to rationalize the stereocontrol.
An Aluminium Imide as a Transfer Agent for the [NR]2−Function via Metathesis Chemistry
Authors: Heilmann Andreas , Vasko Petra , Hicks Jamie , Goicoechea Jose M. , Aldridge Simon 
Published: January 2023

AbstractThe reactions of a terminal aluminium imide with a range of oxygen‐containing substrates have been probed with a view to developing its use as a novel main group transfer agent for the [NR]2−fragment. We demonstrate transfer of the imide moiety to [N2], [CO] and [Ph(H)C] units driven thermodynamically by Al−O bond formation. N2O reacts rapidly to generate the organoazide DippN3(Dipp=2,6‐iPr2C6H3), while CO2(under dilute reaction conditions) yields the corresponding isocyanate, DippNCO. Mechanistic studies, using both experimental and quantum chemical techniques, identify a carbamate complex K2[(NON)Al‐{κ2−(N,O)−N(Dipp)CO2}]2(formed via [2+2] cycloaddition) as an intermediate in the formation of DippNCO, and also in an alternative reaction leading to the generation of the amino−dicarboxylate complex K2[(NON)Al{κ2−(O,O′)−(O2C)2N‐(Dipp)}] (via the take‐up of a second equivalent of CO2). In the case of benzaldehyde, a similar [2+2] cycloaddition process generates the metallacyclic hemi‐aminal complex, Kn[(NON)Al{κ2−(N,O)−(N(Dipp)C(Ph)(H)O}]n. Extrusion of the imine, PhC(H)NDipp, via cyclo‐reversion is disfavoured thermally, due to the high energy of the putative aluminium oxide co‐product, K2[(NON)Al(O)]2. However, addition of CO2allows the imine to be released, driven by the formation of the thermodynamically more stable aluminium carbonate co‐product, K2[(NON)Al(κ2−(O,O′)−CO3)]2.
Mechanism of NO removal in selective catalytic reduction based on γ‐Fe2O3 catalyst doped with Mg element
Authors: Hao Wencong , Ren Dongdong , Luo Siyi , Zuo Zongliang 
Published: January 2023

AbstractThe doping of different elements will make the Fe2O3 catalyst show different catalytic characteristics and improve the activity of the Fe2O3 catalyst in selective catalytic reduction (SCR), mainly by increasing the types of reactive oxygen species and the specific surface area of the catalyst. In this paper, density functional theory (DFT) was used to reveal the reaction path and adsorption behaviour of the Mg‐doped γ‐Fe2O3 catalyst. The results show that the doping of Mg ions can contribute electrons and lead to electron migration on the catalyst surface, which changes the acidity of some sites on the catalyst surface. The adsorption energy of NH3 is related to the binding sites of N atoms on the catalyst surface, and different adsorption sites will be enhanced or weakened due to Mg doping. NH2 reacts with NO to form N2 and H2O, so the dehydrogenation of NH3 to the NH2 radical is a key step in SCR. With doping, this process becomes more likely to occur. In addition, the activation energy barrier of NH2 formation in the aerobic environment is lower than that in the anaerobic condition, which contributes to NH3 dehydrogenation. Therefore, doping Mg on the surface of γ‐Fe2O3 catalyst can improve the catalytic activity of NO removal.
Pembrolizumab induced remission of recurrent and metastatic sinonasal squamous cell carcinoma after overcoming checkpoint‐inhibitor pneumonitis: A case report and literature review
Authors: Nair Deepak Rajendran , Trehan Ram 
Published: January 2023

AbstractBackgroundFor programmed death‐ligand‐1 (PD‐L1) positive recurrent and metastatic head and neck squamous cell carcinoma (R/M‐HNSCC), KEYNOTE‐048 and KEYNOTE‐040 clinical trials recently approved pembrolizumab monotherapy as first‐line treatment. However, recurrent and metastatic sinonasal squamous cell carcinoma (R/M‐SNSCC) was excluded from these clinical trials and treatment reports of immune‐checkpoint inhibitor (ICI) in R/M‐SNSCC are sparse. Immune‐related adverse events (irAEs) are known to occur during ICI treatment and some of these such as checkpoint‐inhibitor pneumonitis (CIP) can be fatal. ICI rechallenge after severe irAEs is debated.CaseWe describe a case of a 65‐year‐old male with R/M‐SNSCC who is currently in remission with pembrolizumab monotherapy. He developed high‐grade pneumonitis during the course of treatment warranting ICI discontinuation but has since tolerated full‐dose pembrolizumab for 10 months now which is holding his disease stable. Our approach toward restarting full‐dose pembrolizumab was by monitoring the patient's response to an initial low dose of pembrolizumab with concomitant oral steroid immunosuppression to control CIP.ConclusionClinicians should weigh the risk‐to‐reward ratio of ICI rechallenge after improvement of high‐grade CIP, particularly for selected patients with aggressive tumors such as R/M‐SNSCC and prior treatment response. Under close monitoring, ICI resumption at a low dose and assessing patient tolerance with concomitant immunosuppression may be a reasonable approach to reintroducing ICI after high‐grade CIP in these patients.
Optimized ensemble learning‐based student's performance prediction with weighted rough set theory enabled feature mining
Authors: Sateesh Nayani , Srinivasa Rao Pasupureddy , Rajya Lakshmi Davuluri 
Published: January 2023

SummaryCurrently, educational data mining act as a major part of student performance prediction approaches and their applications. However, more ensemble methods are needed to improve the student performance prediction, and also which helps increase the learning quality of the Student's performance. The usage of an ensemble classifier with rule mining to predict students' academic success is proposed. In response to this need, this research mainly concentrated on an ensemble classifier with rule mining to predict students' academic success. The feature mining is performed using the weighted Rough Set Theory method, in which the proposed meta‐heuristic algorithm optimizes the weight function. The variable optimization of the ensemble classifier is accomplished with the help of a combination of Harris Hawks Optimization (HHO), and Krill Herd Algorithm (KHA) known as Escape Energy Searched Krill Herd‐Harris Hawks Optimization (EES‐KHHO) for maximizing the prediction rate. Extensive tests are carried out on various datasets, and the findings show that our technique outperforms conventional approaches. Throughout the result analysis, the offered method attains a 92.77% accuracy rate, and also it attains a sensitivity rate of 94.87%. Therefore, the offered student performance prediction model achieves better effectiveness regarding various performance metrics.
Oral granulomatosis with polyangiitis a systematic review
Authors: Labrador Alberto J. Peraza , Valdez Luciano H. M. , Marin Nestor R. Gonzalez , Ibazetta Karem A. R. , Chacón Joan A. L. , Fernandez Alberto J. V. , Valencia Marcelo S. V. , Marchant Schillin W. , Sanchez Katman B. T. , Villacrez Cesar A. 
Published: January 2023

AbstractObjectiveGranulomatosis with polyangiitis is an unusual multisystemic inflammatory disease, with vasculitis of small‐ and medium‐sized vessels, with a predilection for upper lower airways and kidneys. The etiology remains unknown although it may originate from different stimuli, in genetically susceptible patients.Materials and MethodsA detailed database search was performed. The variables were demographics, localization, histopathological findings, antineutrophil cytoplasmic autoantibody, cytoplasmic (c‐ANCA) tests, treatment, and follow‐up.ResultsFifty‐two cases were identified; the mean age was 49.6 years, with a range from 6 to 87 years. It was most frequently seen in females (57.7%). The most common race was white (59.6%). The most frequent location was in the maxillary gingiva (28.8%), followed by both the upper and lower gingiva (19.2%). The most common clinical presentation was “strawberry gingivitis” (61.5%). The main symptom was pain, in 50%. Regarding the c‐ANCA test, it was positive in 71.2% of cases. The most common therapy was prednisone and cyclophosphamide, utilized in 51.9%. The average follow‐up was 23.6 months, and 88.5% of patients were still alive at follow‐up.ConclusionThe diagnosis initially was difficult to establish, an early diagnosis and treatment are mandatory. If untreated the disease can be associated with morbidity and mortality. For the oral clinician, this disease needs to be addressed in the differential diagnosis of oral lesions.
Electrolyte Engineering Stabilizes Photoanodes Decorated with Molecular Catalysts
Authors: Jenewein Ken J. , Wang Yuanxing , Liu Tianying , McDonald Tara , Zlatar Matej , Kulyk Nadiia , Benavente Llorente Victoria , Kormányos Attila , Wang Dunwei , Cherevko Serhiy 
Published: January 2023

AbstractMolecular catalysts are promising oxygen evolution promoters in conjunction with photoanodes for solar water splitting. Maintaining the stability of both photoabsorber and cocatalyst is still a prime challenge, with many efforts tackling this issue through sophisticated material designs. Such approaches often mask the importance of the electrode‐electrolyte interface and overlook easily tunable system parameters, such as the electrolyte environment, to improve efficiency. We provide a systematic study on the activity‐stability relationship of a prominent Fe2O3 photoanode modified with Ir molecular catalysts using in situ mass spectroscopy. After gaining detailed insights into the dissolution behavior of the Ir cocatalyst, a comprehensive pH study is conducted to probe the impact of the electrolyte on the performance. An inverse trend in Fe and Ir stability is found, with the best activity‐stability synergy obtained at pH 9.7. The results bring awareness to the overall photostability and electrolyte engineering when advancing catalysts for solar water splitting.
A 6‐to‐38Gb/s capture‐range bang‐bang clock and data recovery circuit with deliberate‐current‐mismatch frequency detection and interpolation‐based multiphase clock generation
Authors: Wang Lin , Chen Yong , Yang Chaowei , Zhou Xionghui , Han Mei , Stefano Crovetti Paolo , Mak Pui‐In , Martins Rui P. 
Published: January 2023

SummaryThis paper reports a bang‐bang clock and data recovery circuit (BBCDR) with an ultra‐wide capture range. The circuit exhibits automatic frequency capture and phase locking over a wide 6‐to‐38 Gb/s range without using a frequency detector, allowed by a recently proposed deliberate‐current‐mismatch technique. Moreover, we accurately obtain an eight‐phase clock through analog interpolation of quadrature signals over the whole wide frequency range by introducing a tunable capacitor array before an inverter‐based phase interpolator. A 65‐nm prototype of the developed BBCDR occupies an area of 0.07 mm2 and attains a bit error rate of less than 10−12 under a continuously variable input frequency, with a total power consumption of 24.6 mW for a 32‐Gb/s non‐return‐zero input, thus leading to 0.769‐pJ/bit energy efficiency.