bluuebunny/crossref_metadata_2025_split huggingface dataset:
Molecular disparity of HLA‐DPB1 is associated with the development of subsequent solid cancer after allogeneic hematopoietic stem cell transplantation
Authors: Zou Jun , Kongtim Piyanuch , Oran Betül , Srour Samer A. , Greenbaum Uri , Carmazzi Yudith , Rondon Gabriela , Ciurea Stefan O. , Ma Qing , Shpall Elizabeth J. , Champlin Richard E. , Cao Kai 
Published: February 2023

AbstractBackgroundAn increased incidence of subsequent solid cancers (SSCs) has been reported in long‐term survivors of allogeneic hematopoietic stem cell transplantation (allo‐HSCT), and SSC is associated with inferior mortality and morbidity. Previous studies showed that the incidence of SSC is significantly higher in those who underwent allo‐HSCT from HLA‐mismatched donors, suggesting that persistent alloimmunity may predispose patients to SSCs. It was recently reported that, in a cohort of patients who received allo‐HSCT from an unrelated donor matched at HLA‐A, ‐B, ‐C, ‐DRB1/3/4/5, and ‐DQB1 loci, HLA‐DPB1 alloimmunity determined by high mismatched eplets (MEs) and Predicted Indirectly Recognizable HLA Epitopes (PIRCHE) score (PS), was associated with relapse protection and increased risk of acute graft‐versus‐host disease (GVHD).MethodsIn the present study, the impact of HLA‐DPB1 alloimmunity assessed by molecular mismatch algorithms on the development of SSCs in a cohort of 1514 patients who underwent allo‐HSCT for hematologic malignancies was further investigated. ME load at the HLA‐DPB1 locus was measured using the HLAMatchmaker module incorporated in HLA Fusion software, and the PS for mismatched HLA‐DPB1 was calculated using the HSCT module from the PIRCHE online matching service.ResultsIn multivariable analysis after adjusting for baseline risk factors, higher ME, PS‐I, and PS‐II in the GVH direction, but not in the HVG direction, were associated with an increased risk of SSCs (ME: subdistribution hazard ratio [SHR] 1.58, p = .01; PS‐I: SHR 1.59, p = .009; PS‐II: SHR 1.71, p = .003). In contrast, nonpermissive HLA‐DPB1 mismatches defined by the conventional T‐cell epitope algorithm were not predictive of the risk of SSCs. Moreover, posttransplant cyclophosphamide‐based GVHD prophylaxis was associated with a reduced risk of subsequent solid cancer (SHR 0.34, p = .021).ConclusionsThese results indicate for the first time that increased GVH alloreactivity could contribute to the development of SSCs in allo‐HSCT survivors.
Pediatric magnetoencephalography
Authors: Nordli Douglas R. , Galan Fernando N. 
Published: February 2023

AbstractMagnetoencephalography (MEG) is a technology used in pediatric and adult epilepsy that records magnetic fields produced from electric currents in the brain. MEG can locate epileptogenic zone(s), lateralize language functions, localize sensorimotor cortex, and identify visually evoked fields. It is a powerful technology with key advantages in pediatrics. The majority of its limitations are resource driven. With advancing technology, MEG will become a more prominent and valuable tool used in pediatric epilepsy and epilepsy surgery in the future. We review MEG and provide illustrative cases to showcase its usage.
Digital transformation and environmental performance: Evidence from Chinese resource‐based enterprises
Authors: Xu Qiong , Li Xin , Guo Fei 
Published: February 2023

AbstractDigitalization is of great significance for resource‐based enterprises to break through the dual constraints of resource and environment. Based on the data of China's A‐share resource‐based listed enterprises, this study empirically examines the direct effect and transmission mechanism of digital transformation on the enterprises' environmental performance. The study finds that digital transformation significantly enhances the environmental performance of enterprises by stimulating green technology innovation, accelerating human capital accumulation, increasing environmental information disclosure, and strengthening environmental governance. The environmental performance of state‐owned, large‐size and high‐tech resource‐based enterprises is more prominently affected by digital transformation. In the eastern region and areas with higher environmental regulation, the impact of digital transformation on the environmental performance of resource‐based enterprises is more significant. This study provides targeted suggestions for resource‐based enterprises to make full use of the digital dividends and achieve high‐quality development.
Intestinal fibrosis in aganglionic segment of Hirschsprung's disease revealed by single‐cell RNA sequencing
Authors: He Shiwei , Wang Junfeng , Huang Yanlei , Kong Fanyang , Yang Ran , Zhan Yong , Li Zifeng , Ye Chunjing , Meng Lingdu , Ren Yankang , Zhou Ying , Chen Gong , Shen Zhen , Sun Song , Zheng Shan , Dong Rui 
Published: February 2023

AbstractBackgroundHirschsprung's disease (HSCR) is a relatively common congenital disability. Accumulating extracellular matrix (ECM) prompts intestinal fibrosis remodelling in the aganglionic segments of HSCR. The contributions of various cellular subsets in the fibrogenesis of HSCR segments are poorly understood.MethodsSingle‐cell transcriptomics from 8 aganglionic segments and 5 normal segments of 7 HSCR subjects and 26 healthy segments of seven healthy donors were analysed. Fibrotic phenotype and alterations were explored using differential expression analysis and single‐cell trajectory analysis. Fibrosis‐related transcription factors were inferred through single‐cell regulatory network inference. Bulk transcriptomic data, proteomic data, immunohistochemistry (IHC) and real‐time polymerase chain reaction were used to validate the alterations in the HSCR intestine.ResultsVarious collagen, fibronectin and laminin protein‐coding genes expression were up‐regulated in the stromal and glial cells of the HSCR intestine. The number of fibroblasts and myofibroblasts in the aganglionic segments increased, and more myofibroblasts were activated at an earlier stage in HSCR segments, which infers that there is an intestinal fibrosis phenotype in HSCR segments. The fibrotic regulators POSTN, ANXA1 and HSP70 were highly expressed in the ECM‐related cellular subsets in the transitional segments and aganglionic segments. The transcription factor regulatory network revealed that fibrosis‐related and megacolon‐related NR2F1 in the fibroblasts and glial subsets was up‐regulated in the aganglionic segment.ConclusionsThis work identifies intestinal fibrosis and related regulators in aganglionic segments of HSCR; hence, anti‐fibrotic therapy may be considered to prevent HSCR‐associated enterocolitis (HAEC), relieve intestinal stricture and improve cell therapy.
Influence of natal habitat preference on habitat selection during extra‐home range movements in a large ungulate
Authors: Hooven Nathan D. , Springer Matthew T. , Nielsen Clayton K. , Schauber Eric M. 
Published: February 2023

AbstractNatal habitat preference induction (NHPI) occurs when animals exhibit a preference for new habitat that is similar to that which they experienced in their natal environment, potentially leading to post‐dispersal success. While the study of NHPI is typically focused on post‐settlement home ranges, we investigated how this behavior may manifest during extra‐home range movements (EHRMs), both to identify exploratory prospecting behavior and assess how natal habitat cues may influence path selection before settlement. We analyzed GPS collar relocation data collected during 79 EHRMs made by 34 juvenile and subadult white‐tailed deer (Odocoileus virginianus) across an agricultural landscape with highly fragmented forests in Illinois, USA. We developed a workflow to measure multidimensional natal habitat dissimilarity for each EHRM relocation and fit step‐selection functions to evaluate whether natal habitat similarity explained habitat selection along movement paths. Across seasons, selection for natal habitat similarity was generally weak during excursive movements, but strong during dispersals, indicating that NHPI is manifested in dispersal habitat selection in this study system and bolstering the hypothesis that excursive movements differ functionally from dispersal. Our approach for extending the NHPI hypothesis to behavior during EHRMs can be applied to a variety of taxa and can expand our understanding of how individual behavioral variation and early life experience may shape connectivity and resistance across landscapes.
Spatial variation of pollen receipt and effects of heterospecific pollen on seed set in Salvia przewalskii
Authors: Fang Qiang , Zhang Tao , Montgomery Benjamin R. 
Published: February 2023

AbstractGeneralized pollinators visit multiple co‐flowering plant species and may transfer heterospecific pollen grains. Recent studies have indicated that the effect of heterospecific pollen (HP) on reproduction success is variable and depends on the identity of donor and recipient species. However, few studies have documented variation in HP receipt and evaluated the reproductive effects of HP receipt across geographic locations under natural conditions. We investigated the spatial variation of pollen deposition across eight sites and how the pollen receipt related to the seed set of Salvia przewalskii, a subalpine perennial herb in Hengduan Mountain in southwest China. We found that stigmatic pollen loads substantially varied among sites for several metrics, including quantities of conspecific and heterospecific pollen, the proportion of HP, and species composition of HP donors. Five different plant families were the most common HP source at one or two sites, and the proportion of HP ranged from 3.4% to 51.3% across sites. The association of conspecific pollen with seed set was positive and variable among sites, whereas the association of HP receipt and seed set was negative and not significantly different among sites. Our results demonstrate variation in the quantity and fitness effect of pollen receipt across sites, which is a precondition for evolution of local adaptation. Further study of variation in patterns and effects of HP receipt for the same recipient species across natural communities would allow better understanding of the ecological and evolutionary consequences of HP receipt.
Modeling and coordinated control for active power regulation of pumped storage‐battery integrated system under small‐disturbances
Authors: Wang Zhecheng , Yang Weijia , Liao Yiwen , Li Yulan 
Published: February 2023

AbstractMultienergy complementation is an important means to improve the capacity of renewable energy consumption and the key to achieving the goal of “net zero” globally. The hydro–wind–photovoltaic‐storage hybrid system is an important technical approach, and in this system, pumped storage and battery energy storage are both key components for regulation. To study the problem of coordinated control of the two storage systems, a model of a pumped storage‐battery integrated system (PSBIS) for simulating small disturbances of pumped storage units and the battery charge and discharge characteristics was established by MATLAB/Simulink in this study firstly. Then, two control strategies (“priority regulation of pumped storage” and “priority regulation of battery storage”) are studied, and simulation calculations under ideal input and measured wind power disturbances are carried out to compare two control strategies by using the integrated system model under grid‐connected conditions. The simulation results revealed that the “priority regulation of pumped storage” control strategy has a better performance on active power balance, compared with the “priority regulation of battery storage” control strategy. This work could provide technical support for coordinated control of the practical PSBIS in the future.
Comparative experimental study on macroscopic spray characteristics of various oxygenated diesel fuels
Authors: Bao Jianhui , Wang Haohao , Wang Ruofei , Wang Qingxin , Di Liming , Shi Cheng 
Published: February 2023

AbstractUnder high ambient pressure (5 MPa) and different injection pressures (90, 120, and 150 MPa), a high‐speed imaging technique was carried out to comparatively investigate the macroscopic spray characteristics of diesel with three different types of blended fuel in a constant volume chamber. The oxygenated fuels were n‐butanol (B), pine oil (P), and 2,5‐dimethylfuran (DMF). All their blending ratio with diesel were 20%. Results showed that less viscosity could be improved the spray characteristics of the fuel in the range of experimental conditions. Then, the tested fuels had a longer penetration and a greater spray area with increasing the injection pressure from 90 to 150 MPa. On the other hand, the percentage increases in the mean spray cone angle of D100, B20, P20, and DMF20 were 3%, 4.4%, 2.4%, and 2.9%, respectively. At the same experimental condition, the spray penetrations of DMF20 and P20 were larger than that of D100, but the spray penetration of B20 was basically similar to D100. Besides, the performance of the spray cone angle and spray area were D100 < B20 < P20 < DMF20. In addition, the comprehensive influence was that blending oxygenated fuels would be a benefit for developing fuel atomization and the air–fuel mixture of conventional diesel fuel.
Theoretical analysis of drilling cuttings considering stress zoning of surrounding rock and its application in stress detection
Authors: Geng Yanfeng , Tan Jian , Yin Yanchun , Tan Yunliang 
Published: February 2023

AbstractDrilling cuttings method is a commonly used method to detect the risk of rockburst, which has been widely recognized and applied in coal mines. However, in the current theoretical research on the relationship between drilling cuttings method and coal stress, it is generally considered that the mechanical parameters of coal at different positions of roadway are unchanged, and the influence of surrounding rock plastic zone and elastic zone is not considered. Therefore, according to the secondary distribution characteristics of roadway side stress, the theoretical calculation formula of drilling cuttings in the plastic zone and elastic zone of the roadway side is established in this paper. The example shows that the distribution of cuttings on the roadway side is obviously consistent with the abutment pressure. The cuttings in the plastic zone and the elastic zone are in linear and power function with the coal stress, respectively, and the cuttings in the plastic zone are greater than those in the elastic zone. With the increase of the hole diameter, the slope of the relationship curve between the drill‐cutting weight and stress gradually increases, and the response of the drill‐cutting weight with a large hole diameter to the change of coal stress is more obvious. The numerical simulation results show that the error of the theoretical calculation formula of the drilling cuttings method is less than 9%, which can meet the engineering application needs of estimating the drill‐cutting weight in coal and the stress of coal. Using the theoretical formula, the stress field in the leading area of the working face is measured, and the leading influence range and the accurate position of the high stress concentration area are determined, which provides more comprehensive stress information for the early warning of impact danger and pressure relief.
Day‐ahead scheduling of a hybrid renewable energy system based on generation forecasting using a deep‐learning approach
Authors: Zamanidou Afroditi , Giannakopoulos Dionysios , Pappa Dimitra , Pitsilis Vasilis , Makropoulos Constantinos , Manolitsis Konstantinos 
Published: February 2023

AbstractA significant amount of electricity in numerous regions worldwide is used for lighting roads, squares, and other public spaces. Renewable energy can contribute notably to electricity usage for public lighting. This paper focuses on the day‐ahead scheduling of a hybrid renewable energy system (HRES) exploiting solar–wind energy potential to meet the electrical energy needs of public lighting. The studied HRES provides electricity for a Wi‐Fi hotspot and a charging hotspot for the end users and has an energy storage system that ensures a reliable electricity supply without interruptions. The day‐ahead scheduling of the studied HRES is based on electricity generation forecasting by using a deep‐learning approach. Particularly, the long short‐term memory model is utilized, considering the fact that it is able to perceive long‐term dependencies among the time series. Moreover, the model's performance is investigated through the determination of diverse inputs: (a) historical data, (b) weather predictions, and (c) historical data with weather predictions. Multiple scenarios of energy consumption are assumed and applied to optimize the day‐ahead scheduling. A new recommendation method is proposed and applied for day‐ahead scheduling, utilizing the power forecasts to achieve optimum operation and energy savings. The results point out that the utilization of the proposed recommendation method controls loads when a shortage in power generation and battery capacity is forecasted for the day ahead, leading to significant energy savings and minimizing the power demand from the grid.
Validation of the name Quercus infectoria subsp. veneris var. pfaeffingeri (Fagaceae)
Authors: Panahi Parisa , Jamzad Ziba 
Published: February 2023

AbstractQuercus infectoria Oliv. is a taxon with high morphological variation, and many infra‐specific have been described in this species, of which Q. infectoria Oliv. subsp. veneris (A.Kern) Meikle is present in the flora of Iran. In a taxonomic review of the Quercus L. taxa in Iran, based on morphological and micromorphological evidence, we recognized a new combination: Q. infectoria Oliv. subsp. boissieri (Reut.) O. Schwarz var. pfaeffingeri (Kotschy) Jamzad and Panahi, as a distinct taxon. Since the valid subspecific name for this taxon is subsp. veneris (A.Kern) Meikle var. pfaeffingeri, and the basionym of this name was not defined in the published manuscript. Here we correct the authorship and validate this name. Furthermore, we present the taxonomic history of Q. infectoria, descriptions of infraspecific taxa, a distribution map in Iran, ecological notes, and an identification key to infraspecific taxa.
Influence of extraction techniques on the efficiency of pomegranate (Punica granatum L.) peel extracts in oxidative stability of edible oils
Authors: Javani‐Seraji Samira , Bazargani‐Gilani Behnaz , Aghajani Narjes 
Published: February 2023

AbstractIn this study, the effects of pomegranate (Punica granatum L.) peel extract (PPE) on the oxidative stability of soybean oil and ghee were investigated under heat conditions. Three extraction methods (immersion, ultrasound, and combined immersion‐ultrasound) with eight solvents (hot water, cold water, absolute methanol, methanol 50%, absolute ethanol, ethanol 50%, absolute acetone, and acetone 50%) were used for the evaluation of the extracts. Ethanolic extract in maceration method significantly (p ≤ .05) showed the highest DPPH radical scavenging activity (95.018%), reducing power (3.981), and total phenolic content (520 mg GAE/g) compared to the other samples. Then, the effects of PPE in various concentrations (200, 400, 600, and 800 ppm) were compared to the synthetic antioxidant (Butylated hydroxytoluene 200 ppm) in the oxidative stability of soybean oil under 65°C and ghee under 55°C for 24 days with 6‐day intervals, respectively. During storage period, all treatments showed a significant decrease (p ≤ .05) in peroxide value, thiobarbituric acid reactive substances, conjugated dienes value, polar compounds value, and acid value compared to the control. Except for the PPE 200 treatment, the other treatments exhibited superior efficiency to the synthetic antioxidant in a dose‐dependent manner in accelerated stored edible oils. Based on the sensory analyses (flavor, odor, color, and overall acceptability), PPE significantly (p ≤ .05) preserved the sensory features compared to the control group during the entire storage time. PPE 800 ppm was the most efficient treatment in all analyses, followed by PPE 600, 400, and 200 ppm, respectively. Finally, it was concluded that PPE can be introduced as a unique alternative to synthetic antioxidants in edible oils under heating conditions.
The practice of manager as coach (MAC): Unequal power relations and their effect on feelings toward the organization
Authors: Ben‐Hador Batia 
Published: February 2023

AbstractManager as Coach (MAC) is a concept that relates to managers who actively coach their subordinates to improve their skills, competence, and performance. The MAC practice is a popular tool for managers in organizations; however, there is a debate about the benefits gained from coaching by MACs and a theoretical gap regarding the effectiveness of this process. The purpose of this study is to examine the different perceptions of managers who coach their subordinates and subordinates coached by their managers of the coaching process and to estimate the perceived success of this process. In‐depth interviews were conducted with 13 MACs and 9 coachees from various organizations in Israel. Qualitative content analysis was used to analyze and interpret the data. Basic analysis indicates that the perceptions of the MACs toward the coaching process were positive, whereas the coachees held mixed perceptions. The different perceptions point to the unequal power relations between the MACs and the coachees. In the interpretive analysis, it was found that the perceptions toward the MAC process affect coachee feelings toward the organization but not the coach's feelings. Relying on Leader‐Member Exchange (LMX) theory, the MAC process will be successful only if managers significantly reduce power distances. Therefore, organizations must offer their MACs significant coaching training to decrease the negative consequences of the MAC practice and to diminish the power distance between MAC and coachee.
Cut‐to‐the‐light technique is useful for complete obstruction of a Wallace ureteroileal anastomosis
Authors: Tsuboi Ichiro , Yokoyama Shuhei , Nakajima Hirochika , Yosioka Saori , Kobayashi Yusuke , Nagami Taichi , Ogawa Kohei , Wada Koichiro 
Published: February 2023

IntroductionObstruction of a ureteroileal anastomosis after urinary diversion is an unpleasant situation for patients and clinicians alike.Case presentationA 48‐year‐old man who underwent a radical cystectomy for muscle‐invasive bladder cancer and urinary diversion using the Wallace technique complained of right back pain. Computed tomography showed right hydronephrosis. Cystoscopy via the ileal conduit revealed complete obstruction of the ureteroileal anastomosis. We performed a bilateral approach (antegrade and retrograde) to use the cut‐to‐the‐light technique. A guidewire and 7Fr single J catheter could be inserted.ConclusionThe cut‐to‐the‐light technique was useful for complete obstruction of the ureteroileal anastomosis, the length of which was <1 cm. Herein, we report on the cut‐to‐the‐light technique with a literature review.