bluuebunny/crossref_metadata_2025_split huggingface dataset:
Testosterone and sexual function in menopausal women based on the Female Sexual Function Index (FSFI) score
Authors: Khoiri Muhammad Agung , Siregar Muhammad Fidel Ganis , Lumbanraja Sarma Nursani , Effendi Iman Helmi , Sudewo Yudha , Ardiansyah Edy , Eyanoer Putri 
Published: August 2023

HIGHLIGHTS

Testosterone level correlates with FSFI score, showing that sexual function correlates with hormonal physiology.
FSFI is a valid and useful tool in measuring sexual function.

ABSTRACT
Objective: This research aimed to analyze the correlation between testosterone levels and sexual function in postmenopausal women.
Materials and Methods: This research was a descriptive observational study with a case series approach conducted at Aras Kabu Health Center Outpatient Polyclinic from May to August 2022. The normality test was carried out using the Shapiro-Wilk test. If the data were not normally distributed, data would be analyzed using the Spearman correlation test. If the data were normally distributed, the data analysis would use the Pearson correlation test.
Results: There was a significant relationship between Female Sexual Function Index (FSFI) score with testosterone levels and duration of menopause with p<0.05. The degree of correlation found was 0.619 between testosterone levels and FSFI scores, indicating a moderate and significant positive correlation. A correlation degree of 0.482 was found between FSFI and length of menopause which indicated a significant moderate positive correlation, while the degree of correlation between testosterone levels and length of menopause was found to be 0.711, showing a strong and significant positive correlation.
Conclusion: There is a significant relationship between FSFI scores with testosterone levels and duration of menopause as well. There was also a significant relationship between testosterone levels and the duration of menopause.
THE DEVELOPMENT MODEL OF COMMUNITY-BASED TOURISM IN NAGARI KOTO SANI, SOLOK REGENCY, WEST SUMATRA
Authors: Nofrion Nofrion , Purwanto Sulis , Utomo Erwin Pri , Aziz Saddam Al 
Published: August 2023

<p>The development of a community-based tourism village gives wider authority to the community to manage the potential of their village and has an impact on improving the economy and sustainable development. The purpose of this research was to find a community-based tourism development model in Nagari Koto Sani which has natural and cultural potential as a tourism village. This qualitative approach of research collects data through observation, interviews, focused discussions and documentation studies. The data is then analyzed using qualitative analysis with triangulation, so that the data obtained is valid and saturated. The results of the research show that the development model of community-based tourism village consists of three main stages, i.e., planning, implementation and reflection. Activities at the planning stage include, 1) identification of the potential of the village (Nagari), 2) focused discussions regarding the views and aspirations of the community, 3) preparation of the RIPPDES draft, 4) focused discussions regarding familiarization of the tourism village program. Then, the activities at the implementation stage are 1) community awareness, 2) strengthening local resources, 3) cooperation between stakeholders, and 4) tourism village promotion. Finally, at the reflection stage, the activities carried out are 1) observation and monitoring, 2) follow-up plans. <em></em></p>
EXTENT OF CYANIDE, NITRATE, AND FLAVONOIDS GOITROGENS IN SOILS AND TOBACCO PLANT IN SOKOTO, NIGERIA
Authors: Umar AI , Sarkingobir Yusuf , Tambari Umar , Salau Ibrahim Alhaji , Aliyu Sulaiman , Gobir Shehu Sarkin , Miya Yusuf Yahaya 
Published: August 2023

<p>Nitrate, cyanide, and flavonoids are among the chemicals that threatens hormones especially the thyroid gland and in turn affecting the body. Their presence in tobacco and cigarette shall be determine to inform the public. The objective of this work was to determine the extent of nitrate, cyanide, and flavonoids in soil and tobacco from Sokoto, Nigeria using standard methods. The results determined by this work indicated varied levels of goitrogens (cyanide, nitrate, and flavonoids) present in soils and tobacco leaves grown in three different points within Sokoto state, Nigeria (namely, Sokoto city, Gwadabawa, and Illela). 100.21±6.12 -705.10±4.60ppm, ppm 136± 6.10-170.30±3.36ppm, 7.10±0.3-17.0±0.11ppm are range values of cyanide, nitrate, and flavonoids respectively obtained in soils in Sokoto state. Likewise, 90.0±2.16-500.0±1.3ppm, 70.11±3.9-120.0±10.3ppm, 6.2±0.5-25.11±0.05ppm are the ranges of cyanide, nitrate, and flavonoids respectively determined in tobacco leaves in Sokoto state, Nigeria. There exist elevated levels of the goitrogens in soils and tobacco in Sokoto, therefore, risking the consumers and non-consumers to iodine deficiency. </p>
A Pure Mathematical Proof of the 4-Colour Theorem
Authors: Wang John 
Published: August 2023

Abstract
This work "A Pure Mathematical Proof of the 4-Colour Theorem" is related to the previous proof assited by computer. "Triangulations of Euler Convex Polygon" provides a fresh beginning point for the proof. The central concept is to discover an extended invariant property of Standard Graph’s boundary, which is described as "3-Colour All Phase States (3CP)" in this work and it is demonstrated that the standard graph’s boundary and sub-bound are 3CP and 4-colorable（4-3CP） via the expanded operation e(+, pi) and e(-, pi). It's exciting that this regularity was discovered for the first time and the 4-3CP invariant can naturally derive the 4-Colour Theorem. The majority of the definitions, theorems, and proof strategies are shown in this work.
Trajectory Tracking Control of Parking Automated Guided Vehicles using Nonlinear Disturbance Observer-based Sliding Mode
Authors: Hu Xudong , Zhu Bo , Tan Dongkui , Zhang Nong 
Published: August 2023

Abstract
In order to improve the convenience of parking and increase parking density, automated valet parking systems based on parking AGVs (P-AGVs) are gradually becoming popular in cities. Parking AGVs can move toward any position and attain any orientation simultaneously with its Mecanum wheels, which makes it very convenient to transport vehicles in the parking lot. This paper proposes a nonlinear disturbance observer-based sliding mode controller for the trajectory tracking problem of a Parking AGV. First, a kinematics and dynamics models of a Parking AGV tracking trajectory are analyzed sequentially, and the influences of disturbing forces are considered. Afterwards, a nonlinear disturbance observer (NDO) is designed to estimate the disturbing forces and torques generated by castor wheels. Based on the designed NDO, a robust nonsingular terminal sliding mode (NTSM) controller is utilized to track reference trajectories. In addition, the stability of the NDO and NDO-NTSM control system is theoretically verified by using Lyapunov function. Finally, simulations and experiments are carried out to certify the effectiveness of the proposed control scheme. Experiment results show that the proposed NDO-NTSM controller can track the reference trajectories well and improve the trajectory tracking stability by 42–68% in comparison with a traditional NTSM controller.
The application of data mining technology in hospital performance management under the background of big data
Authors: Li Ying , Wang Kehua , Xu Chuanchuan 
Published: August 2023

Abstract
With the rapid development of computer and information technology, all walks of life have realized informatization, and the industries and fields covered by informatization technology almost cover the daily life. In all aspects, the medical industry is paying more and more attention to informatization construction. From the initial manual documents to the later electronic prescriptions, from the previous focus on equipment, to the gradual focus on software, from passive acceptance in the past to the active use of software to cooperate with management, there are various signs that the medical industry has gone through It has entered the stage of "information electronization", and has entered an important period of relying on information technology. With the gradual development of the effect of business intelligence on hospital management decision support, the expansion of hospital information systems, the accumulation of data, and the upgrading of technology, new contents, functions and applications are continuously introduced. Through the construction of data mining, it helps the hospital to initially realize the transformation from the information system provider to the decision support assistant, and becomes the starting point and effect feedback point of the hospital management decision. This paper analyzes the application history and current situation of data mining in hospitals, as well as the main advantages of data mining in hospital performance management for reference.
Correlation study of AADAC with prognosis and immunoinfiltration of gastric cancer based on bioinformatics analysis
Authors: Zhan Xiangyang , Li Haoze , Jin Jingyun , Yuan Zhongzhao , Liu WenRui , Zhou Jielong , Li Xuehui , Gu Jianyi , Xu Dongliang 
Published: August 2023

Abstract
Objective
Using bioinformatics to screen key prognostic genes for gastric cancer and exploring the immune infiltration relevance of these genes, providing new therapeutic targets for the diagnosis and treatment of gastric cancer.
Methods
Screening of differentially expressed genes based on TCGA and GEO databases, and performing GO and KEGG pathway enrichment analysis. Further selection of key prognostic genes for gastric cancer through COX regression and Lasso regression algorithms, and construction of a prognostic risk model. Drawing ROC curve and K-M survival curve to evaluate the prognostic value of genes. Analyzing the immune infiltration level of genes using CIBERSORT, ssGSEA algorithm, and TIMER database, and combining with HPA database to analyze the gene expression. Results: A total of 67 differentially expressed genes were screened out,the key prognostic gene AADAC in gastric cancer was identified, and a risk prognostic model was constructed. The ROC curve and AUC value indicate that the risk model has good predictive value. The K-M survival curve indicates that patients with high expression of AADAC have a worse survival outcome. The results of immune infiltration analysis suggest that the infiltration levels of activated B cells, CD56(dim) natural killer cells, central memory CD4 + T cells, central memory CD8 + T cells, eosinophils, immature B cells, macrophages, mast cells, monocytes, and helper T cells are positively correlated with the risk score. The expression of AADAC is weakly positively correlated with B cells, CD4 + T cells, and macrophages. Immunohistochemical results from the HPA database suggest that the staining intensity of AADAC in normal gastric mucosal tissues is weaker than that in gastric cancer tissues.
Conclusion
AADAC can effectively predict the prognosis of gastric cancer patients and is moderately correlated with the level of immune infiltration, providing a new direction for the diagnosis and immunotherapy of gastric cancer.
The global, regional, and national testicular cancer burden and trends from 1990 to 2019: results from the Global Burden of Disease Study 2019
Authors: Huang Guoxin , Li Han , Chen Xiali , Liu Ying , Jiang Chenglu , Zhang Shengke , Pei Bin , Sun Zhou 
Published: August 2023

Abstract
Background:To assess the disease burden of Testicular Cancer (TC) from 1990 to 2019.
Methods:Global, regional and national age-standardized incidence rate (ASIR), age-standardized prevalence rate (ASPR), age-standardized death rate (ASDR) and age-standardized disability-adjusted life years rate (DALYs) from 1990-2019 were used to analyze the disease burden of TC, combined with decomposition analyses and frontier analyses.
Results: The global ADIR, ASPR, ASDR, and age-standardized DALYs in 2019 were 2.79 (2.36,3.33), 21.24 (17.59,25.94), 0.28 (0.26,0.31), and 14.24 (12.91,15.98), respectively. The burden of disease varied by region and country, with Central Europe and Southern Latin America having higher than expected levels. Chile, Tonga, and Monaco were among the countries with a higher disease burden. Decomposition analysis showed population growth as the main factor for changing age-standardized DALYs. Frontier analysis showed that age-standardized DALYs in different countries have much room for improvement, especially in Tonga and Kiribati. The global ADIR, ASPR, ASDR, and age-standardized DALYs are projected to be 3.13, 24.08, 0.29, and 15.01 by 2030.
Conclusions: TC remains a global public problem. There are significant regional and national differences, and therefore different regions and countries should be targeted to improve the disease burden of TC.
Multilevel analysis on magnitude and factors associated with unmet need for family planning among reproductive age women in world poorest countries: Further analysis of recent demographic health survey data
Authors: Alie Melsew Setegn 
Published: August 2023

Abstract
Background
Unmet need for family planning is the contributor and devastating issue of maternal health. Meting the unmet need of contraceptive averts the maternal and newborn death. Unmet need for family planning is one factor for low improvement of maternal health and contribute to high population growth especially in Africa. Therefore, describing prevalence of unmet need and its determinants is very important to intervene and design appropriate program umbrella.
Objective
To describe the factors associated with unmet need for family planning among reproductive age women in poorest world countries.
Method
This study analyzed secondary data from Demographic and Health Surveys of which contained detailed family planning for all interviewed women aged 15 to 49 years. The variables of the study were extracted from women’s individual record (IR) data set using STATA version 15. The data were weighted using sampling weight before any statistical analysis to account the sampling design. STATA version 15 was used for editing, recoding, exploratory and multivariable analysis. Appropriateness of multilevel analysis were done and null model, model with individual variable, model with community level variable and model with both individual and community level variable were built. Both bivariable and multivariable multilevel analysis was done. Variable with p-value < 0.25 were selected for multivariable multilevel logistic regression analysis. Variables with p-value ≤ 5% declared as statistical significant with outcome variable.
Results
The magnitude of unmet need among reproductive age women in poorest countries were 27.55% (95% CI 23.44, 28.9). Factors associated with unmet need family which was identified in this study were women age group of 25–35 years [AOR = 0.89; 95% CI 0.85–0.94], women’s in age group of > = 36[AOR = 1.14; 95% CI 1.07,1.22], women’s residing in Urban area [AOR = 0.85; 95% CI 0.8,0.91], and households lead by female [AOR = 1.26; 95% CI 1.2, 1.32] were the determinants of unmet need for family planning.
Conclusion
Unmet need for family planning contributes for unintended pregnancy and unsafe abortion that finally results maternal mortality. In the current study, unmet need for family planning were high. Living in rural, divorced or widowed or separated, maternal age 25–35 year, maternal educational status primary and above, women who had any work, exposure on FP in newspaper, media exposure, intention to use family planning were the protective factors. Whereas age of women greater than 35, women currently working, female headed household, desire of child, husbands desire for a child were the risk factors for unmet need for family planning. Factor specific with considering the same socioeconomic status of the country should be consider to design the policies and programs.
Age affects lateral spurring after pediatric humerus lateral condyle fractures: A retrospective cohort study
Authors: Liu Tao , Wen Wu , Dong Chuan , Liu Yu , Yin Xing , Han Saiping , Zhou Wei , Li Nan , Li Yuancheng 
Published: August 2023

Abstract
Background:
Lateral spurring is frequently observed after lateral condyle fractures of the humerus in children. Despite its frequent recognition, few previous studies have defined this phenomenon, explored a correlation with any fracture or treatment characteristics, nor assessed its clinical significance.
Methods:
Information of 146 lateral condyle fractures in children from June 2015 to September 2021 were retrospectively analyzed and an database was established. Lateral spurring was defined as a bony overgrowth over the lateral aspect of the lateral condyle resulting in imaging irregularity on radiography. Univariable and multivariable logistic regression analyses were used to identify independent risk factors for lateral spurring, and a receiver operating characteristic (ROC) curve was used to assess the impact of independent risk factors.
Results:
Among the 146 fractures identified, 6.6% were treated with cast immobilization, 93.4% with open reduction and internal fixation, and none with closed reduction and percutaneous pinning. In total, 110(75.3%) patients developed a lateral spur, age was identified as an independent risk factor for lateral spurring(P<0.001), and the area under the ROC curve (AUC) was 0.806(95% confidence interval [CI] 0.729-0.883, P<0.001). At age 61.5 months, the Youden index reached its maximum with a sensitivity of 86.1% and specificity of 65.5%, Patients with age less than 61.5 months had a higher lateral spurring, the Relative Prevalence (RP) was 1.70.
Conclusions:
The development of lateral spurring closely correlates with patient age, the incidence of lateral spurring decreases with age, the incidence of lateral spurring was higher in patients younger than 61.5 months. The presence of a lateral spur after an LCF of the humerus does not influence the function or the appearance of the elbow.
Level of Evidence:
Level Ⅳ— retrospective study.
Disparities in Long-Term Outcomes Between Benign and Malignant Diseases After Hartmann’s Procedure: A Retrospective Observational Study
Authors: Imaizumi Ken , Kasajima Hiroyuki , Sato Aya , Sato Kentaro , Ito Keiichiro , Fukasawa Takumu , Ichimura Kentaro , Odagiri Makoto , Yamana Daisuke , Tsuruga Yosuke , Umehara Minoru , Kurushima Michihiro , Nakanishi Kazuaki 
Published: August 2023

Abstract
Background: The long-term course following Hartmann’s procedure may vary by primary disease, but remains unclear. Herein, we aimed to compare the incidence of reversal after Hartmann’s procedure (HR) between benign and malignant diseases and explore post-HR long-term outcomes.
Methods: Patients who underwent Hartmann’s procedure between June 2005 and December 2021 at a single center were retrospectively evaluated. The primary endpoint was the difference in HR incidence between benign and malignant diseases. The secondary endpoints were identification of the predictive factors for HR incidence and stoma-free survival and anorectal functions after reversal between patients with benign and malignant diseases.
Results: Among 261 patients, the benign and malignant disease groups comprised 102 and 159, respectively. Cumulative HR incidence was significantly lower in the in the malignant disease than in the benign disease groups (P <0.001). However, malignant disease was not an independent factor for HR in the multivariate analysis. Low Charlson’s comorbidity index (P <0.001), urgent Hartmann’s procedure (performed as a lifesaving procedure; P <0.001), and home discharge (P <0.001) were significantly associated with HR incidence. Among 43 patients who underwent HR, the rate of stoma-free survival in the malignant disease group reduced significantly as the duration from reversal increased compared with the benign disease group (P=0.020). No significant between-group differences were observed in anorectal function (n=23).
Conclusion: The incidence of HR and the stoma-free survival rate after HR may be lower in patients with malignant disease than in those with benign disease, although anorectal function after HR did not differ significantly.
Predicted broadly neutralizing antibody (bnAb) resistance and associated envelope characteristics of adults with HIV-1 seroconversion in Botswana
Authors: Moraka Natasha Onalenna , Choga Wonderful T. , Pema Marea N. , Chawawa Moses K. , Gobe Irene , Mokomane Margaret , Bareng Ontlametse T. , Bhebhe Lynnette , Kelentse Nametso , Mulenga Graceful , Pretorius-Holme Molly , Mohammed Terence , Koofhethile Catherine K. , Makhema Joseph M. , Shapiro Roger , Lockman Shahin , Moyo Sikhulile , Gaseitsiwe Simani 
Published: August 2023

Abstract
We used HIV-1C sequences to predict (in silico) resistance to 33 known broadly neutralizing antibodies (bNAbs) and evaluate the different HIV-1 env characteristics that may affect virus neutralization.
We analyzed proviral sequences from adults with documented HIV-1 seroconversion (N=140) in Botswana (2013-2018). HIV-1 env sequences were used to predict bnAb resistance using bNAb-ReP, to determine the number of potential N-linked glycosylation sites (PNGS) and evaluate env variable region characteristics (VC). We also assessed the presence of signature mutations that may affect bnAb sensitivity in vitro.
We observe varied results for predicted bnAb resistance among our cohort. 3BNC117 showed high predicted resistance (72%) compared to intermediate levels of resistance to VRC01 (57%). We predict low resistance to PGDM100 and 10-1074 and no resistance to 4E10. No difference was observed in the frequency of PNGS by bNAb susceptibility patterns except for higher number of PNGs in V3 bnAb resistant strains. Associations of VC were observed for V1, V4 and V5 loop length and net charge. We also observed few mutations that have been reported to confer bnAb resistance in vitro.
Our results support use of sequence data and machine learning tools to predict the best bnAbs to use within populations.
Emotional intelligence as a predictor of job satisfaction among midwives in Northern Iran: a cross-sectional study
Authors: Zolfaghary Fatemeh , Adib-Rad Hajar , Pasha Hajar , Bakouei Fatemeh , Osko Sahar , MashaghiTabari Reza 
Published: August 2023

Abstract
Background Emotional Intelligence (EI) is an important skill for midwives. Our study aimed to understand EI as a Predictor of Job Satisfaction among Midwives.
Methods This descriptive-correlational study was conducted on 143 employed midwives in maternity wards of government and private hospitals, as well as healthcare centers in Iran. The data were collected using demographic-fertility Characteristics, emotional intelligence, and job satisfaction questionnaires. For the assessment of EI, the Bar-On's Emotional Intelligence questionnaire was used which consists of 90 items. For the assessment of job satisfaction, Herzberg's Job Satisfaction Questionnaire was used which consists of 72 items. The significance level of the tests was considered to be P<0.05.
Results The results of the study showed that the average EI and job satisfaction of midwives were moderate (316.57±33.64 and 278.58±25.95 respectively). According to Pearson correlation coefficients, there was a significant positive correlation between total job satisfaction and total EI scores (r=0.356, p<0.001). According to the results of multiple linear regression analysis after adjusting for other variables, job satisfaction of midwives had a significant positive association with total EI and friendly relationship with supervisors (β=0.258, p=0.022 and β=0.267, p=0.046 respectively).
Conclusion This study showed that high emotional intelligence enhances midwives' job satisfaction. So midwifery managers should create conditions that help enhance the Emotional Intelligence and satisfaction of midwives.