bluuebunny/crossref_metadata_2025_split huggingface dataset:
Amar e mudar as coisas no arco-íris de Euá: Sagrado Não Binário, Epistemologia do A(fé)to e Teologia Queer de Orixá como alternativas à transfobia religiosa
Authors: Maranhão Du Flor 
Published: February 2023

Resumo:Comento aqui, de modo ensaístico, sobre Euá (Ewá), a Orixá do Arco Íris, que podemos compreender como a orixá do amar e mudar as coisas, graças a algumas de suas qualidades, como a sensibilidade e delicadeza; a clarividência, intuição e sexto sentido; e a criatividade, imaginação e inteligência. A partir das qualidades de Euá e de características que tradicionalmente são atribuídas a ela e a quem a segue, gostaria de instigar novas reflexões e diálogos acerca de papeis e interpretações de gênero desempenhadas em ambientes religiosos/espiritualistas/esotéricos; ventilando algumas provocações através de conceitos como teologia queer de orixás, sagrado não binário e epistemologia do a(fé)to, aqui pensados como alternativas à transfobia religiosa/espiritualista/esotérica, mas que podem ser aplicados por quem lê este texto em uma miríade de possibilidades.
Pola Bimbingan Belajar Orangtua di Rumah dalam Pengenalan Lambang Bilangan AUD masa BDR
Authors: Nggalu Bali Engelbertus , Manilani Christine Andriani , Djokaho Margatera P. E. 
Published: February 2023

This study aims to describe the pattern of parental guidance at home in developing the ability to recognize number symbols in early childhood BDR. This type of research is descriptive qualitative research. The data collection technique was through interviews with 10 parents with early childhood, as well as observations made on the entire process of parental maturation during BDR. The results of the study describe the pattern of parental tutoring carried out through 3 stages, namely 1) directing and making agreements with children in the form of gifts (rewards) and giving punishment (punishment), 2) monitoring of practices related to the tutoring process carried out by parents, namely using 4 types of activities, namely activities of imitating, connecting and bolding number symbols, using number symbol posters and using videos learning YouTube and games on smartphones, 3) correction of parents seeing obstacles/obstacles encountered during the learning process and solutions to overcome them as well as evaluating and not continuing. Parents have very diverse patterns and are very influential on the development of children's number symbols.
Novel Genetic Variants Associated with Chronic Kidney Disease Progression
Authors: Han Miyeun , Moon Sungji , Lee Sangjun , Kim Kyungsik , An Woo Ju , Ryu Hyunjin , Kang Eunjeong , Ahn Jung-Hyuck , Sung Hye Youn , Park Yong Seek , Lee Seung Eun , Lee Sang-Ho , Jeong Kyung Hwan , Ahn Curie , Kelly Tanika N. , Hsu Jesse Y. , Feldman Harold I. , Park Sue K. , Oh Kook-Hwan 
Published: February 2023

Significance Statement
eGFR slope has been used as a surrogate outcome for progression of CKD. However, genetic markers associated with eGFR slope among patients with CKD were unknown. We aimed to identify genetic susceptibility loci associated with eGFR slope. A two-phase genome-wide association study identified single nucleotide polymorphisms (SNPs) in TPPP and FAT1-LINC02374, and 22 of them were used to derive polygenic risk scores that mark the decline of eGFR by disrupting binding of nearby transcription factors. This work is the first to identify the impact of TPPP and FAT1-LINC02374 on CKD progression, providing predictive markers for the decline of eGFR in patients with CKD.

Background
The incidence of CKD is associated with genetic factors. However, genetic markers associated with the progression of CKD have not been fully elucidated.

Methods
We conducted a genome-wide association study among 1738 patients with CKD, mainly from the KoreaN cohort study for Outcomes in patients With CKD. The outcome was eGFR slope. We performed a replication study for discovered single nucleotide polymorphisms (SNPs) with P<10−6 in 2498 patients with CKD from the Chronic Renal Insufficiency Cohort study. Several expression quantitative trait loci (eQTL) studies, pathway enrichment analyses, exploration of epigenetic architecture, and predicting disruption of transcription factor (TF) binding sites explored potential biological implications of the loci. We developed and evaluated the effect of polygenic risk scores (PRS) on incident CKD outcomes.

Results
SNPs in two novel loci, TPPP and FAT1-LINC02374, were replicated (rs59402340 in TPPP, P
discovery=7.11×10−7, P
CRIC=8.13×10−4, P
meta=7.23×10−8; rs28629773 in FAT1-LINC02374, P
discovery=6.08×10−7, P
CRIC=4.33×10−2, P
meta=1.87×10−7). The eQTL studies revealed that the replicated SNPs regulated the expression level of nearby genes associated with kidney function. Furthermore, these SNPs were near gene enhancer regions and predicted to disrupt the binding of TFs. PRS based on the independently significant top 22 SNPs were significantly associated with CKD outcomes.

Conclusions
This study demonstrates that SNP markers in the TPPP and FAT1-LINC02374 loci could be predictive markers for the decline of eGFR in patients with CKD.
Política pública para imigrantes: os desafios no acesso aos serviços da Atenção Primária em Saúde (APS) em Lajeado/RS
Authors: Brandt Grazielle Betina , Areosa Silvia Virginia Coutinho , Rodrigues Karen Priscila 
Published: February 2023

O presente artigo apresenta o recorte de uma pesquisa no campo de Desenvolvimento Regional, realizada no município de Lajeado/RS no ano de 2021. Foram selecionados dois serviços de saúde que atendem o maior número de imigrantes no município, a Estratégia de Saúde da Família (ESF) São José Praia e a Unidade Básica de Saúde (UBS) Moinhos, e, além destes, a 16ª Coordenadoria Regional de Saúde (CRS), responsável pelos serviços da região. A partir a escolha dos serviços em saúde foi realizada uma pesquisa de abordagem qualitativa, com a realização de entrevistas semiestruturadas com um total de 13 sujeitos, entre eles oito profissionais da saúde, quatro imigrantes haitianos e uma gestora, coordenadora regional da Política de Atenção Primária em Saúde. O objetivo deste estudo foi contextualizar os desafios no acesso a serviços prestados para imigrantes no Sistema Único de Saúde (SUS). A partir dos resultados da pesquisa, identificamos a necessidade de se criarem políticas públicas específicas para imigrantes no SUS, pois acreditamos que o planejamento das ações de saúde deve levar em conta a influência cultural desses sujeitos, e para isso, há a necessidade de se pensarem políticas públicas que atendam as especificidades advindas dos fatores culturais. Ainda, entre os principais resultados dessa pesquisa, apontamos como desafios nos atendimentos da APS de Lajeado/RS a barreira linguística, os ritos religiosos e de saúde como fator a serem considerados na prestação aos serviços de saúde para imigrantes. Acreditamos que a construção de políticas públicas específicas para essa comunidade, constitui-se num importante papel para diminuir as desigualdades na prestação dos serviços e a discriminação em torno das práticas culturais de imigrantes no sistema de saúde.
Empresas Multinacionales Chinas: Efectos en la pobreza mundial
Authors: Neme Castillo Omar , Chiatchoua Cesaire , Briseño Perezyera José Israel 
Published: February 2023

El objetivo del presente trabajo fue determinar el efecto que tienen las empresas multinacionales chinas en la reducción de la pobreza en un grupo de 36 países de ingreso alto y medio-alto en los que operaron en el periodo 2009-2018. Se emplea una metodología econométrica de datos de panel dinámica. Se encuentra que estas multinacionales influyen positivamente en la reducción de la pobreza. En consecuencia, pueden ser consideradas como un mecanismo central de la dinámica global de la pobreza. El documento contribuye a la escaza literatura que analiza cuantitativamente el papel de las multinacionales chinas en lareducción de la pobreza.
El teletrabajo como mitigador de los impactos económicos de la pandemia del COVID-19.
Authors: De la Vega Pablo , Gasparini Leonardo 
Published: February 2023

Este artículo estima el papel del teletrabajo como mitigador del impacto de la pandemia del COVID-19 en el mercado laboral argentino. Para ese propósito, se analiza la relación entre el potencial de teletrabajo a nivel ocupacional estimado en base a tres encuestas diferentes (O*NET, PIAAC, y STEP), y los resultados del mercado laboral a nivel individual, explotando la estructura de paneles rotativosde la encuesta nacional de hogares. Se encontró que durante el pico de las restricciones por la pandemia, el potencial del teletrabajo estuvo positivamente relacionado con la probabilidad de estar activo y empleado. Estos efectos están concentrados en la submuestra de trabajadores “no esenciales”. Por el contrario, no encontramos efectos sistemáticos del potencial del teletrabajo en las transiciones laborales antes de la pandemia, lo cual es un resultado consistente con nuestra estrategia de identificación.
From Private to Public
Authors: Khan Amir 
Published: February 2023

The most impressive thing about Andrew Norris’ book is its unflinching and unequivocal ease in bringing us to what I have elsewhere called the Cavellian precipice” through ordinary language philosophy and “external world” skepticism exclusively. That is, this book has a remarkable and fluid grasp of Cavell’s contribution to formal philosophical thought, which literary sorts like myself often eschew explaining precisely because the path to explaining skepticism, for us, feels far more pregnant and urgent when discussing objects of pleasure, namely film and literature.
PCR Positivity of Gerbils and Their Ectoparasites for Leishmania Spp. in a Hyperendemic Focus of Zoonotic Cutaneous Leishmaniasis in Central Iran
Authors: Azarmi Sahar , Zahraei-Ramazani Alireza , Mohebali Mehdi , Rassi Yavar , Akhavan Amir Ahmad , Azarm Amrollah , Dehghan Omid , Elikaee Samira , Abdoli Rahimeh , Mahmoudi Mohsen 
Published: February 2023

Background: Various arthropods, including Rhipicephalus sanguineus and Ctenocephalides felis felis have been sug­gested as secondary vectors of Leishmania spp. many years ago. This study was conducted to determine zoonotic cuta­neous leishmaniasis (ZCL) PCR positivity of reservoir hosts and their ectoparasites for Leishmania spp. in Segzi plain in Esfahan Province from October 2016 to October 2017.
Methods: Microscopic examination and nested PCR were used to detect and identify Leishmania spp. isolated from rodents' ears and ectoparasites, and then, the results were confirmed by two methods, PCR-restriction fragment length polymorphism and sequencing.
Results: Totally, 93 rodents (92 Rhombomys opimus and one Nesokia indica) and nine different species of ectoparasites (n=527) including fleas, mites, and ticks were collected during different seasons in the study area. Fourteen R. opimus were positive for Leishmania spp. by microscopic examination while one N. indica and 77 R. opimus were positive by nested PCR. The infection rate of rodents with Leishmania major and Leishmania turanica was 39.79% (n=37) and 15.05% (n=14), respectively. Mixed natural infections with L. major and L. turanica were seen in rodents. Moreover, 72.22% of fleas (39/54), 75.0% of mites (5/8), and 100% of tick nymph (1/1) were PCR positive for Leishmania parasites.
Conclusions: The highest rate of infection with L. major and L. turanica in R. opimus populations was observed in summer and spring, respectively. It is suggested that the role of L. turanica and the probable role of ectoparasites in the epidemiology of disease should be investigated. A Xenodiagnostic test is recommended for future study.
In dogs diagnosed with osteoarthritis, how safe and effective is long-term treatment with bedinvetmab in providing analgesia?
Authors: Kronenberger Katrin 
Published: February 2023

PICO question
In dogs diagnosed with osteoarthritis (OA), how safe is treatment with bedinvetmab, when compared to a placebo and how effective in long-term reduction of the severity of the clinical signs associated with OA-related pain?

Clinical bottom line
Category of research
Treatment.
Number and type of study designs reviewed
Two papers were critically reviewed. One was a randomised, blinded, multi-arm laboratory safety study; the other a multi-center field trial consisting of a block-randomised, double blind, placebo-controlled phase, followed by a non-comparative, open-label case series study.
Strength of evidence
Weak.
Outcomes reported
One study rated the reduction of the severity of clinical signs associated with OA pain using owner Canine Brief Pain Inventory (CBPI) ratings and non-validated veterinary clinical assessments (VCAs). Safety was addressed by evaluating adverse health effects (AHEs), concentration of antidrug antibodies (ADAs), and clinical pathology. Significant improvements in pain scores and VCAs were reported in this treatment study. The second safety-only study used clinical observation to evaluate AHEs. Both studies reported AHEs.
Conclusion
A single study suggests that treatment with bedinvetmab is effective. Two studies support the drug having few AHEs. Both studies have significant design limitations preventing the evaluation of bedinvetmab effectiveness. There is weak / inconclusive evidence for long-term efficacy and short-term safety of OA treatment with bedinvetmab. The decision to use bedinvetmab remains dependent on the judgement and experience of the clinician.
How to apply this evidence in practice
The application of evidence into practice should take into account multiple factors, not limited to: individual clinical expertise, patient’s circumstances and owners’ values, country, location or clinic where you work, the individual case in front of you, the availability of therapies and resources.
Knowledge Summaries are a resource to help reinforce or inform decision making. They do not override the responsibility or judgement of the practitioner to do what is best for the animal in their care.
Application Cow Manure and Mychorriza to Physiological of Biduri (Calotropis gigantea)
Authors: Hartati Sri , Samanhudi Samanhudi , Rahayu Muji , Sukardan Mochammad Danny , Rahma Nadia Alifia 
Published: February 2023

<p>Biduri (<em>Calotropis gigantea</em>) was a wild plant that had many benefits in the health and textile industries. In the health sector, biduri was used as a herbal plant, while in the textile industry, used as the main raw material. Biduri could be used as a substitute for kapok as the main raw material, therefore it was necessary to develop cultivation technology to met the needs. This research was conducted at the Jumantono Field Laboratory of Faculty of Agriculture UNS, Karanganyar using a factorial Randomized Complete Block Design (RCBD), which consisted of 2 factors, namely cow dung fertilizer, and mycorrhizae. Cow dung fertilizer consists of 0 ton/ha, 10 ton/ha, and 20 ton/ha. Mycorrhizae consisted of 0 grams/plant, 5 grams/plant, 10gram/plant, and 15gram/plant. There were 36 treatment combination that consist of 12 treatment combination repeated 3 times. The interaction between cow dung did not significantly affect all physiological observation variables. The results showed that the application of 20 ton/ha of cow dung fertilizer gave the best results on the width of stomata openings, the rate of photosynthesis, and the rate of transpiration. Inoculation with mycorrhizal fungi had no significant effect on all observations of physiological variables </p><p><strong>Keywords: </strong><em>Calotropis gigantea</em>, cow manure, mycorrhiza, physiological</p>
A FEATURES OF FORMING OF FINANCIAL RESULTS OF AGRICULTURAL ENTERPRISE
Authors: Falchenko Olena , Yatsyna Viktoriia , Kochetova Tetyana 
Published: February 2023

In the article essence over of agricultural enterprises is brought after the type of economic activity as a legal entity, the basic type of activity of which is growing and processing of agricultural produce and specific of agriculture, as to the type of economic activity. The financial results of agricultural enterprises as economic category which represents effectiveness of activity of agricultural enterprise are considered. General methodology of determination of financial results of agricultural activity is analysed on accordance to the real model of market economy. The existent substantial features of forming of financial results in agricultural enterprises, which are predefined by the accepted legislative base, at which biological assets and regulated order of their confession, estimation and account are certain and accordingly which the constituents of financial results of agricultural enterprises, and also features of forming of financial result, belong in agricultural enterprises in connection with the specific of industrial and economic activity of industry, are educed. Composition of profits of agricultural enterprises and composition of charges of agricultural enterprises are considered, due to what an income is determined on every type of activity separately by comparison of profits and charges on agricultural enterprises. The basic internal source of forming of financial results of agricultural enterprises, which is income and her influence on economic activity in agriculture is certain. Substantial influence is marked on a size and forming of financial results of agricultural enterprises of estimation of products on a fair value at primitive confession. The order of methodology of forming of financial results of agricultural enterprises is recommended on the basis of the conducted research at a record-keeping. Drawn conclusion, that forming of financial results of agricultural enterprises is the extraordinarily important aspect of their activity and foresees development of certain organizationally-methodical measures with the aim of creation of integral control system by the income of enterprises.
DEVELOPMENT OF UKRAINE IN THE ASPECT OF "MAINTAINING" OF THE EFFECTIVE LEVEL OF ITS ECONOMIC SECURITY
Authors: Garmash Sergii 
Published: February 2023

The purpose of the article is to analyze open sources of information in order to systematize information to analyze the situation that has developed in Ukraine over the years of independence in the context of aspects of activities for the sake of "maintaining" the most effective level of economic security; identification of negative trends in the development of Ukrainian society and the presentation of practical recommendations to prevent further destruction of statehood. For thirty years of independence, it has been proven that Ukraine has two main enemies: 1) foreign speculative capital; 2) the local oligarchy, which serves this very capital for the sake of its own preferences, being on the criminal offshore "hook" of these very foreign "partners" who are cynically and systematically tearing the country apart and robbing its people. The main interconnected derivatives from these "enemies" and even already components of the process of transforming the country from a subject into an object of foreign influence are: 1) lack of professionalism at all levels of moral and intellectual degraders, who all these years have been trying to get to the state trough for the sake of their own preferences, posing as "statists", with the full support of foreign "partners"; 2) moral and intellectual impoverishment of representatives of the Ukrainian government at all levels, who act in their own "pocket" interests at the expense of the interests of ordinary citizens of Ukraine during the cynical robbery of the country by several local oligarchic clans and foreign monopolies for the purpose of their own enrichment. During the years of independence, there has been a lot of talk by representatives of the authorities and the oligarchy about the successes of the country's "development", but modern realities confirm the opposite thought. Political events of recent months show that Ukraine should have its own state interests: American investments, European technologies and Russian markets are important for the country. Until the Ukrainian oligarchs and those who serve their interests in power understand that they should not make their country and their people "consumables" for the sake of the interests of outside players, until then the country will not have a chance for its independent development in the future.
Surgical Treatment of Single-Level Lumbar Stenosis Is Associated with Lower 2-Year Mortality and Total Cost Compared with Nonsurgical Treatment
Authors: Hwang Raymond W. , Briggs Catherine M. , Greenwald Scott D. , Manberg Paul J. , Chamoun Nassib G. , Tromanhauser Scott G. 
Published: February 2023

Background:
Spine surgery has demonstrated cost-effectiveness in reducing pain and restoring function, but the impact of spine surgery relative to nonsurgical care on longer-term outcomes has been less well described. Our objective was to compare single-level surgical treatment for lumbar stenosis, with or without spondylolisthesis, and nonsurgical treatment with respect to patient mortality, resource utilization, and health-care payments over the first 2 years following initial treatment.

Methods:
A retrospective review of the Medicare National Database Fee for Service Files from 2011 to 2017 was performed. A 2-year prediction of mortality risk (risk stratification index, RSI) was used as a measure of patient baseline health. Patients (88%) were matched by RSI and demographics. Mortality, spine-related health-care utilization, and 2-year total Medicare payments for patients undergoing surgical treatment were compared with matched patients undergoing nonsurgical treatment.

Results:
We identified 61,534 patients with stenosis alone and 83,813 with stenosis and spondylolisthesis. Surgical treatment was associated with 28% lower 2-year mortality compared with matched patients undergoing nonsurgical treatment. Total Medicare payments were significantly lower for patients with stenosis alone undergoing laminectomy alone and for patients with stenosis and spondylolisthesis undergoing laminectomy with or without fusion compared with patients undergoing nonsurgical treatment. There was no significant difference in mortality when fusion or laminectomy was compared with combined fusion and laminectomy. However, laminectomy alone was associated with significantly lower 2-year payments when treating stenosis with or without spondylolisthesis.

Conclusions:
Surgical treatment for stenosis with or without spondylolisthesis within the Medicare population was associated with significantly lower mortality and total medical payments at 2 years compared with nonsurgical treatment, although residual confounding could have contributed to these findings.

Level of Evidence:
Therapeutic Level III. See Instructions for Authors for a complete description of levels of evidence.