bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stability Indicating Analytical Method, Characterization of Degradation
Impurity by UPLC-Q-TOF-MS/MS, and Establishment of Degradation
Mechanism of Evodiamine
Authors: Adye Daya Raju , Sahu Amit Kumar , Rajput Niraj , Panday Niraj Kumar , Sengupta Pinaki 
Published: June 2023

Aim:
The current research aims to establish a stability-indicating analytical method (SIAM) for
the quantification of evodiamine (EVO), characterization of its degradation impurity, and establishment
of possible degradation pathways.

Background:
None of the degradation impurities of EVO is known and the mechanism of their formation
has not been reported in any literature to date. Moreover, a SIAM for EVO is not available in any public
domain.

Objective:
The objective of this study is to characterize the degradation impurity of EVO by LC-MS/MS,
proposing its molecular structure, identifying possible degradation pathways of generation of its impurity,
and establishing a SIAM.

Method:
To assist future product development, a degradation study of EVO was performed and an RPHPLC-
based SIAM was developed. The major degradation product was characterized by LC-Q-TOFMS/
MS. In addition, in silico toxicity prediction was performed using the ProTox-ІI toxicity predictor.

Result:
The method was found to be linear, accurate, precise, and robust over the range of 12.5 to 100 μg
/mL of EVO. The method met all the acceptance criteria as specified in the ICH guideline. Only one degradation
product (9% of the drug area) of EVO was generated in acidic hydrolytic conditions. The degradation
product was found to be potentially inactive for hepatotoxicity and immunotoxicity, with a confidence
score of more than 0.7 (70%). Moreover, the confidence score for carcinogenicity, mutagenicity,
and cytotoxicity was less than 0.7, indicating it was moderately inactive for these toxicities.

Conclusion:
The molecule was found to be stable in the majority of the tested stress conditions. However,
the degradation product generated in acidic hydrolytic stress was characterized using LC-Q-TOF-MS/MS,
which was unknown to date. The novelty of this research can be justified by the unavailability of any
SIAM of EVO and the absence of any report on its susceptibility to degradation in the presence of different
potential stressors. Moreover, the potential toxicity of the molecule and its impurity was not known
previously. The reported degradation impurity may be useful to set the quality control acceptance criteria
for EVO. Additionally, pharmaceutical industries and research laboratories may use the developed method
for the analysis of quality control and stability samples of EVO.
Casein Kinase 2 Affects Epilepsy by Regulating Ion Channels: A Potential
Mechanism
Authors: Liu Yan , Xia Di , Zhong Lianmei , Chen Ling , Zhang Linming , Ai Mingda , Mei Rong , Pang Ruijing 
Published: June 2023

Abstract:
Epilepsy, characterized by recurrent seizures and abnormal brain discharges, is the third most common chronic disorder of the Central Nervous System (CNS). Although significant progress has been made in the research on antiepileptic drugs (AEDs), approximately one-third of patients with epilepsy are refractory to these drugs. Thus, research on the pathogenesis of epilepsy is ongoing to find more effective treatments. Many pathological mechanisms are involved in epilepsy, including neuronal apoptosis, mossy fiber sprouting, neuroinflammation, and dysfunction of neuronal ion channels, leading to abnormal neuronal excitatory networks in the brain. CK2 (Casein kinase 2), which plays a critical role in modulating neuronal excitability and synaptic transmission, has been shown to be associated with epilepsy. However, there is limited research on the mechanisms involved. Recent studies have suggested that CK2 is involved in regulating the function of neuronal ion channels by directly phosphorylating them or their binding partners. Therefore, in this review, we will summarize recent research advances regarding the potential role of CK2 regulating ion channels in epilepsy, aiming to provide more evidence for future studies.
Clinical-surgical Characteristics of Patients with Macular Hole. Exilaser Ophthalmological Center. Cuenca, Ecuador. 2015-2019
Authors: Montesinos Giuseppe Miotto , Rojas Alvarez Eduardo , Cabrera Susana Teresa Guerrero , Márquez Marchán Andrea Carolina , Urias Naima Pino 
Published: June 2023

Background:
The macular hole (MH) is one of the least studied ophthalmological pathologies; satisfactory treatment has been achieved through the implementation of surgical techniques a few years ago and the study and analysis of its clinical-surgical characteristics are of vital importance to assess the success of surgery with intrinsic and extrinsic factors.

Objective:
Describe the clinical-surgical characteristics of patients diagnosed with a macular hole at the EXILASER Ophthalmological Center in Cuenca in the period 2015-2019.

Methods:
Descriptive, retrospective study. The study universe corresponds to 75 patients who attended the EXILASER Ophthalmological Center and were diagnosed with MH between January-2015 and December-2019.

Results:
76.0% of the patients are women; 81.3% are between 60 and 79 years old; 96.0% reside in urban areas; 34.7% are dedicated to housework; 24.0% report cataracts; 26.7% have arterial hypertension; 84.0% presented loss of central vision; 80.0% had decreased visual acuity. 50.7% presented affection only in the right eye; 53.3% had a chronic evolution greater than one year; 33.3% presented grade III MH. 44.0% had surgery; 93.9% had anatomical surgical closure. The relationship between the degree of MH, time of evolution, and closure of the MH was not significant (p> 0.05).

Conclusion:
The success rate of MH closure after surgical intervention is greater than 90% with improvement in postoperative visual acuity. No significant association was found between the grade of the MH, time of evolution, and the closure of the MH.
Современные способы тушения литий-ионных аккумуляторов. Часть 3
Authors: Харламенков А. С. 
Published: June 2023

Представлены статистические данные, отражающие состояние парка электромобилей в России. Проведено обобщение основных характеристик аккумуляторных блоков наиболее популярных моделей электро­мобилей в стране. Выполнен анализ существующих мер по обеспечению безопасной эксплуатации тяговых аккумуляторных батарей, снижающих опасность их механического повреждения и теплового разгона. Рассмотрены результаты отдельных зарубежных публикаций по моделированию горения и натурным огневым испытаниям электромобилей в помещениях и открытых пространствах. Даны рекомендации по разработке необходимых мероприятий по организации тушения пожаров с участием электромобилей.
ANALISIS KUANTITAS DAN KUALITAS TENAGA KERJA PERBANKAN SYARIAH YANG TERDAMPAK DISRUPSI DIGITAL
Authors: Melinda Lestari Nur 
Published: June 2023

The challenge for the industrial era 4.0 towards the industrial era 5.0 which is felt by humans is the loss of many skills that are usually carried out by humans who are transferred to technology. The transformation of banking services due to technological disruptions felt by the banking world, conventional services that have been carried out face-to-face have been replaced by technology, business activities and banking products can be said to be disrupted by the emergence of various finances. technology platforms, especially those engaged in P2P Lending and Payment. This can threaten human resources in the banking world if there is no solution and adaptive action taken by the bank so that banking human resources will still have a place according to their level of expertise. Interpreting from primary and secondary data sources, the result is that there has been a significant decrease in the quantity of banking human resources, but simultaneously the bank is reskilling to improve the quality of human resources to be ready to face changes in banking services. towards an excellent service digital banking system that still adheres to the principle of prudence.
Keywords: Digital Services, Challenges of Islamic Banking
ANALISIS PENILAIAN DAN TANGGAPAN ALUMNI PERBANKAN SYARIAH PERIODE 2016-2018
Authors: Melinda Lestari Nur , Yeni Fatma 
Published: June 2023

The tracer study is a tracing study conducted for alumni of the Islamic Banking Department of the Islamic Faculty of UHAMKA who graduated in 2016, 2017, and 2018. Tracer Study is an important part of the existence of universities, especially the Sharia Banking study program in an effort to examine the links and matches of graduate quality in the world of work especially in Islamic banking financial institutions and non-banking Islamic financial institutions with learning services that have been provided during the study period in the Sharia Banking study program. The implementation of tracer studies in tertiary institutions is focused on tracking graduates in order to get feedback from the education/learning processes and services that have been carried out, both to alumni and users of graduates in society (stakeholders). Periodically, the UHAMKA Islamic Banking Study Program conducts a Tracer Study with the aim of improving the quality of learning services based on feedback from alumni and graduate users through this Tracer Study. The Tracer Study of the UHAMKA Islamic Banking Study Program was carried out for graduates in 2016, 2017, and 2018 starting from June to November 2020. The Tracer Study conducted at the UHAMKA Sharia Banking Study Program used the survey method for alumni who graduated two years ago and to the users. In-depth interviews were conducted with several alumni and selected graduate users to strengthen the findings of the tracer study for improving learning services in the UHAMKA Islamic Banking Study Program. The results show that the learning system implemented by the Sharia Banking Study Program can be said to be successful, it's just that the introduction of Al-Islam and Muhammadiyah has to be raised in the future. Data mining was carried out on an IT-based basis in order to reach all the targets of the Tracer Study targets.
Keywords: Tracer Study, Islamic Banking, UHAMKA
RIBA, PERBANKAN SYARIAH, DAN INVESTASI SECARA ISLAMI DI KALANGAN REMAJA
Authors: Marfianti Azzahra Dinar , Hasan Asyari , Akhmad Nadzar Ghabrield , Ilham Kurniawan Muhammad , Andrian Aji Baskoro Raditya , Aqilah Putera Deza Raihan , Adriana Irmadela Redita 
Published: June 2023

The research objective is to look at adolescents'opinion about usury, interest in saving in Islamic banks and investing in Islamic methods. One of the factors affecting economic development in Indonesia is the increase or decrease in interest rates. By using e-view software, the approach used in this study is a qualitative approach using descriptive analysis. The result of this research show that riba is an addition, but this addition creates injustice, this is explained from various sources including Alquran. Islamic financial institutions have a very important role of regulating the Islamic financial system, the principles on this matter are based on the Qur'an and the Sunnah of the Prophet.
Keywords: Interest Money; Usury; Investment; Islamic Financial; Islamic Economy; Islamic Institution in Indonesia
ANALISIS PENGELOLAAN DANA ZAKAT FITRAH SEBAGAI PEMBERDAYAAN EKONOMI UMAT
Authors: Dwi Lestari Novieati , Novita Syafitri Mega , Tishwanah Nuris , Manna Silviyah Nur 
Published: June 2023

Zakat is one of the fifth pillars of Islam and zakat is divided into two, namely zakat fitrah and zakat mal. Whereas Zakat fitrah is zakat issued by muzakki in the form of staple foodstuffs in accordance with the provisions, while zakat mal is zakat issued by muzakki in the form of goods or objects in accordance with the provisions and nishab. The purpose of writing this article is to determine the analysis of the management of zakat fitrah funds as an economic empowerment of the people. The research method used in writing this article is a qualitative research method, which is a method based on natural facts. The approach used is a descriptive approach that tends towards analysis by explaining what it is according to the data obtained.
Keyword : Zakat Fitrah, Management Analysis, Community Economy
ANALISIS PENGELOLAAN KEUANGAN MASJID FATIMAH AT-TUWAIJIRY BEKASI
Authors: Yeni Fatma , Susanto Eko , Fadhli Sultani Zul 
Published: June 2023

The mosque is a place of worship for the Muslim community. Apart from being a place to pray, mosques are also often used as a place to hold religious activities and other social activities such as TPA, breaking fast together, qurban, management meetings, and taklim majlis. Because of the many positive and religious activities that can be held in a mosque, this can be a trigger for the enthusiasm of the mosque congregation, the society or donors to support activities carried out by setting aside some of their assets by providing assistance in the form of money, food. and other forms. Every mosque congregation, the general public or donors who have submitted the assistance that has been distributed, of course, wants what has been submitted to the mosque management to be allocated to things that are useful and in accordance with what they have been entrusted with. Therefore, all parties with an interest in the accountability report for the management of mosque funds expect that they will receive a report whether directly announced every Friday or indirectly, such as a list of receipts and expenditures of funds that is displayed on the mosque wall. The management and financial reporting carried out in each mosque of course have their own differences or characteristics. For example, what happened to one of the mosques in Yogyakarta where the cash owned by the mosque in question always had a zero balance. This is considered very good because any funds that flow to the mosque are always distributed to things that bring benefits to the surrounding community, such as providing boxed rice every Friday and other activities. This study intends to examine how the form of financial management and reporting is carried out by the Fatimah At-Tuwaijiry mosque in Bekasi so that the transparency of its financial reports can be a means of accountability in managing finances mandated by the congregation, the society or donors. The research method used in this study is a qualitative descriptive method, which aims to analyze and provide an overview of the financial reporting and management of the Fatimah At-Tuwaijiry Mosque Bekasi. Data collection techniques were carried out in the form of interviews, observations, and documentation. The results of the study indicate that financial management has been carried out well, this can be seen from the many activities carried out such as holding iftar activities, distributing basic necessities.
Keywords: Management, Reporting, Mosque Finance
INTEGRASI PASAR MODAL ISLAM: STUDI DI LIMA NEGARA ASEAN DAN DJIA
Authors: Al Faridho Awwal Muhammad , Eviyanah Ita , Qoyum Abdul 
Published: June 2023

This study aims to determine the short- and long-term relationship between the Islamic capital market in Southeast Asia and the DJIA. This study takes data from the Islamic capital markets of ASEAN-5 countries, namely the Jakarta Islamic Index (JII), FTSE Malaysia, FTSE SET Sharia Thailand, FTSE SGX Sharia Singapore and MSCI Philippines and DJIA. A total of 211 weekly observations of each index were observed from 04 January 2015, to 03 February 2019. Author have found that the Islamic capital market is integrated in all ASEAN-5 countries including the DJIA. This study also finds that the Malaysian Islamic capital market and DJIA have the most influence on the ASEAN-5 Islamic capital market, as shown by the VDC test.
Keywords; ASEAN, DJIA, Capital Market
PENGARUH MARKETING MIX DAN DIGITAL BANKING TERHADAP KEPUASAN NASABAH PADA BANK SYARIAH INDONESIA CABANG PEKALONGAN PEMUDA DI MASA PANDEMI
Authors: Kustinah Mochamad Yusuf , Taufik Abadi Muhammad , Asytuti Rinda 
Published: June 2023

Bank Syariah Indonesia has a growing number of customers every year. The increase in customers is not matched by the quality of service in the form of customer satisfaction. Customer satisfaction is still an obstacle to maximizing Islamic banks' profits. This study aims to examine the effect of marketing mix and digital banking on customer satisfaction at Bank Syariah Indonesia Pekalongan Pemuda Branch during the pandemic. The sample used was 99 respondents from a population of 17,261. The sample uses an accidental sampling technique. The method uses a questionnaire. Instrument testing, classical assumption analysis, multiple linear regression analysis, and hypothesis testing were used to analyze the data. The results of the analysis conducted on customer satisfaction at Bank Syariah Indonesia Pekalongan Pemuda Branch during the pandemic, namely how digital banking variables affect customer satisfaction, However, the marketing mix has no effect on customer satisfaction.
Keywords: Marketing Mix, Digital Banking, Customer Satisfaction
Representasi Tokoh dalam Syair Ken Tambuhan
Authors: Hikmawaty Hikmawaty 
Published: June 2023

Syair Ken Tambuhan merupakan salah satu naskah kuno berbahasa Melayu yang populer karena kisah cinta Ken Tambuhan dan Raden Menteri yang romantis. Dilatarbelakangi karena syair ini memiliki alur cerita yang menarik, tokoh menjadi salah satu unsur pembangun yang penting. Maka penelitian ini bertujuan untuk menggambarkan tokoh dalam Syair Ken Tambuhan. Penelitian ini menggunakan metode deskriptif kualitatif dengan teori representasi sastra dan pendekatan obyektif menurut Abrams. Tokoh yang diteliti dalam Syair Ken Tambuhan ialah Ken Tambuhan, Raden Menteri, Permaisuri, dan Raja Kuripan. Setiap tokoh memiliki penggambaran yang berbeda sehingga pada penelitian ini tokoh-tokoh tersebut digambarkan. Hasil dari penelitian ini adalah bahwa Syair Ken Tambuhan memiliki 184 halaman tetapi hanya 174 yang terisi. Syair tersebut memiliki beberapa tokoh dengan penggambaran yang variatif, di antaranya: Ken Tambuhan, seorang gadis cantik yang berusia 14 tahun; Raden Menteri, pria berusia 17 tahun yang menawan; Raja Kuripan, seorang raja sekaligus ayah yang baik; dan Permasuri yang memiliki penokohan antagonis karena kejahatannya.
Professional Skepticism in Practice: An Analysis of Auditors’ Stories
Authors: Xu Gina , Yang Cherrie , Fukofuka Peni Tupou 
Published: June 2023

SUMMARY
Professional skepticism is a complex and ambiguous construct. Prior research has primarily focused on examining antecedents that affect professional skepticism. Yet, little is known about auditors’ perceptions and experiences of exercising professional skepticism in everyday audit practice. Through analyzing 78 stories collected from interviewing 35 auditors, our research finds that exercising professional skepticism constitutes a sensemaking process that involves noticing discrepant cues, creating interpretations, and arguing with clients to give sense. Within this process, professional skepticism is constructed by auditors’ microlevel actions and interactions in their collective efforts to seek and interpret meanings of discrepant cues. Prior studies highlight the cognitive and psychological nature of professional skepticism at an individual level. Our study provides an incremental understanding of how professional skepticism is enacted and collectively constructed by auditors in practice and shows that the meanings and practices of professional skepticism are fluid and emergent.
Identification of Hypothalamic Glucoregulatory Neurons That Sense and Respond to Changes in Glycemia
Authors: Deem Jennifer D. , Tingley David , Bjerregaard Anne-Mette , Secher Anna , Chan Owen , Uzo Chukwuemeka , Richardson Nicole E. , Giering Elizabeth , Doan Tammy , Phan Bao A. , Wu Brandon , Scarlett Jarrad M. , Morton Gregory J. , Schwartz Michael W. 
Published: June 2023

To investigate whether glucoregulatory neurons in the hypothalamus can sense and respond to physiological variation in the blood glucose (BG) level, we combined continuous arterial glucose monitoring with continuous measures of the activity of a specific subset of neurons located in the hypothalamic ventromedial nucleus that express pituitary adenylate cyclase activating peptide (VMNPACAP neurons) obtained using fiber photometry. Data were collected in conscious, free-living mice during a 1-h baseline monitoring period and a subsequent 2-h intervention period during which the BG level was raised either by consuming a chow or a high-sucrose meal or by intraperitoneal glucose injection. Cross-correlation analysis revealed that, following a 60- to 90-s delay, interventions that raise the BG level reliably associate with reduced VMNPACAP neuron activity (P &lt; 0.01). In addition, a strong positive correlation between BG and spontaneous VMNPACAP neuron activity was observed under basal conditions but with a much longer (∼25 min) temporal offset, consistent with published evidence that VMNPACAP neuron activation raises the BG level. Together, these findings are suggestive of a closed-loop system whereby VMNPACAP neuron activation increases the BG level; detection of a rising BG level, in turn, feeds back to inhibit these neurons. To our knowledge, these findings constitute the first evidence of a role in glucose homeostasis for glucoregulatory neurocircuits that, like pancreatic β-cells, sense and respond to physiological variation in glycemia.

Article Highlights
By combining continuous arterial glucose monitoring with fiber photometry, studies investigated whether neurons in the murine ventromedial nucleus that express pituitary adenylate cyclase activating peptide (VMNPACAP neurons) detect and respond to changes in glycemia in vivo. VMNPACAP neuron activity rapidly decreases (within &lt;2 min) when the blood glucose level is raised by either food consumption or glucose administration. Spontaneous VMNPACAP neuron activity also correlates positively with glycemia, but with a longer temporal offset, consistent with reports that hyperglycemia is induced by experimental activation of these neurons. Like pancreatic β-cells, neurons in the hypothalamic ventromedial nucleus appear to sense and respond to physiological variation in glycemia.