bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fast Valence Quarks of Short Range Correlated Nucleons in Proton Rich Nucleus
Authors: Wang Taofeng 
Published: July 2023

Abstract
Electron deep inelastic scattering reaction was used to probe the nucleon quark momentum distributions which are featured by the variation of nucleon structure functions between deuterium and heavier nuclei expressed by ∆F2(x) = Fd 2 (x)/2 − FA2 (x)/A under the conditions of Bjorken 0.3 < x < 0.7, Q2 > 1.0 GeV2 and invariant mass W > 1.7 GeV. The negative ∆F2(x) for proton rich nucleus indicate that the average momentum of the valence quark in short range correlated (SRC) nucleons in proton excess nucleus is higher than that in the free nucleons, while ∆F2(x) for the neutron rich and neutron-proton symmetry nucleus were positive under the same conditions. It was concluded that valence quarks take on the relatively faster dynamic motion in the SRC nucleons in the Z > N nuclei
Correlation between ovarian follicular development and Hippo pathway in polycystic ovary syndrome
Authors: Huang Zichao , Xu Tianyue , Wu Honghui , Weng Linglin , Cai Jieyu , Ge Hongshan , Liang Na 
Published: July 2023

Abstract
Background
For women of childbearing age, the biggest problem caused by PCOS is infertility, which is mainly caused by anovulation, abnormal follicular development, proliferation of small antral follicles and the appearance of cystic follicles. The mechanism of its occurrence is not clear. The abnormal proliferation and development of follicles in PCOS patients is a complex process, which is affected by many factors. Previous studies have shown that the switch of Hippo pathway can be regulated by cell volume and cell density.
Result
We found that compared with the control group, the number of small follicles in DHEA group increased, the expression of ovarian reserve function protein AMH increased, the expression of cell proliferation index protein PCNA decreased, and the expression of related proteins in the upstream and downstream of Hippo pathway increased. After administration of VP, the expression of AMH, an indicator of ovarian reserve function, and the expression of related proteins in the upstream and downstream of Hippo pathway decreased.
Conclusion
This study shows that the increase of the number of small follicles in the ovary, the changes of ovarian reserve function and cell proliferation may be closely related to the switch of Hippo pathway, suggesting that the occurrence of PCOS may be closely related to Hippo pathway, and Hippo pathway may be an important pathway affecting the proliferation and development of PCOS follicles.
Study on stress-permeability change of soft coal seam under hydraulic unloading of overlying key strata: numerical simulation and theory
Authors: Li Feng , Wang Bo , Liu Hanwu , Yan Zhengxu , Ren Baorui 
Published: July 2023

Abstract
Based on the geological conditions of low permeability, high gas pressure, high gas content, and high ground stress in soft coal seams, the hydraulic fracturing technology of key strata in overlying strata was proposed. This research mainly focuses on the 8003 excavation working face of a mine in Shanxi as the engineering background, the main and inferior key strata of the overlying strata were determined according to the key strata theory, the hydraulic fracture initiation pressure is measured to be 16MPa, and the influence range is about 15m. `This research established a coal seam permeability model under impacts of effective stress and pore pressure by using simulation software such as FLAC3D to simulate the changes in stress and energy of coal seams before and after fracturing in key strata. Based on results of changes in coal seam permeability and extraction radius, as well as the data of engineering test results, this research also found that fracturing in key strata can cut off the stress transmission path of overlying strata, and thus effectively improving coal seam permeability. The fracturing of the overlying key strata has the effect of unloading and dissipating energy on the coal seam. The stress value and energy values along the inclination and strike of the excavation working face have a varying degree of decreasing trend. With decreasing original stress concentration area of the coal seam, both the stress value and energy values of the deep coal seam are increased. The energy and stress distribution characteristics of the coal seam before and after unloading are basically consistent. After hydraulic fracturing of the key layer, the average gas concentration in the return air flow of the excavation working face decreased from 0.65–0.51%, and the number of coal burst decreased by 95%.
A simple scoring system for predicting the risk of delayed hyponatremia after endoscopic transsphenoidal surgery for pituitary adenomas.
Authors: Mo changhong , Liu Yi , Guo Wei 
Published: July 2023

Abstract
Purpose To identify high-risk patients for delayed postoperative hyponatremia (DPH) early, we constructed a simple and effective scoring system.Methods We retrospectively analyzed 141 consecutive patients who underwent endoscopic transsphenoidal surgery (TSS) from January 2019 to December 2022. Patients were divided into DPH group and non-DPH (NDPH) group based on whether hyponatremia occurred after the third postoperative day. Multivariable logistic regression analysis was conducted to determine the predictive factors of DPH, and a simple scoring system was constructed based on these predictors.Results Among 141 patients, 36 (25.5%) developed DPH. Multivariable logistic regression analysis showed that age ≥ 48 years (OR, 3.77; 95%CI, 1.17–12.19; P = 0.027), Knosp grade ≥ 3 (OR, 5.23; 95%CI, 1.23–22.25; P = 0.025), low blood potassium on the first or second day after surgery (OR, 3.15; 95%CI, 106 − 9.35; P = 0.038), a difference in blood sodium levels between the first and second day after surgery ≥ 1 mEq/L (OR, 3.64; 95%CI, 1.04–12.71; P = 0.043), and postoperative diabetes insipidus (OR, 3.62; 95%CI, 1.21–10.83; P = 0.021) were independent predictors of DPH.Conclusion This scoring system for predicting DPH has an area under the receiver operating characteristic curve (AUC) of 0.856 (95%CI, 0.787–0.925), indicating moderate to good predictive value for DPH in our cohort, but further prospective external validation is needed.
Nonstationarity in the global terrestrial water cycle and its interlinkages in the Anthropocene
Authors: Nie Wanshu , kumar Sujay , Getirana Augusto , Zhao Long , Wrzesien Melissa , Konapala Goutam , Ahmad Shahryar , Locke Kim , Holmes Thomas , Rodell Matthew , Loomis Bryant 
Published: July 2023

Abstract

Warming climate and anthropogenic disturbances alter the global freshwater cycle, causing changes and fluctuations beyond what can be attributed to natural variability alone. A comprehensive understanding of nonstationarity in water cycle components, where trends and fluctuations deviate from the assumption of a stable statistical pattern, remains elusive. Using a remote sensing-informed terrestrial reanalysis, we provide an assessment of nonstationarity in global water cycle components and their interconnections from 2003 to 2020 in terms of trends, seasonal shifts, and changes in extremes. We show that one-third of the global land exhibits strong nonstationarity in terrestrial water storage, with long-term trends contributing the most (47.3%), followed by seasonal shifts (36.2%) and changes in extremes (16.5%). The spatial pattern of nonstationarity in other water cycle variables confirm the intricate interplay of climate variations and human management processes. Our results provide a global quantification of the pervasiveness of nonstationarity in the terrestrial water cycle and highlight the need for adaptive strategies and management approaches to navigate the challenges posed by nonstationary conditions.
Marker-Assisted Gene Pyramiding for Powdery Mildew Resistance in Thai Mungbean Variety SUT1 by Backcross Breeding
Authors: Papan Pitchakon , Chueakhunthod Witsarut , Khairum Apinya , Siwapitakpong Ketwalee , Chaiyapan Chadapon , Inthaisong Sukanya , Jinagool Wanploy , Tharapreuksapong Akkawat , Masari Arada , Kaewkasi Chanwit , Ngampongsai Sumana , Girdthai Teerayoot , Tantasawat Piyada Alisha 
Published: July 2023

Abstract

In Thailand, all Thai cultivated varieties of mungbean [Vigna radiata (L.) R. Wilczek] preferentially grown by farmers are susceptible to powdery mildew (PM) disease. Marker-assisted gene pyramiding (MAGP) for improving resistant varieties is sustainable strategy to overcome its outbreak in mungbean fields. In this study, two PM resistance genes from donor parent A2 were pyramided into Thai cultivated variety, namely Suranaree University of Technology 1 (SUT1) using marker-assisted backcrossing (MAB). Three polymorphic marker loci linked to PM resistance genes and three marker sets with 72 polymorphic loci were subsequently used for foreground and background selection, respectively. As a consequence, three pyramided BC4 lines B1, B2, and D5 carrying all foreground marker loci in homozygosity were obtained. Their recurrent parent genome (RPG) recovery was 100.0%, 100.0%, and 98.8% for background marker Sets A, B, and C, respectively. In field conditions, it was found that a low level of PM severity was exhibited in the pyramided BC line D5, which also had most of the agronomic traits similar or superior to SUT1. Moreover, the yield performance of this line was higher than SUT1, up to 8.3%-12.2% with no disease or PM outbreak. Thus, this pyramided BC line can be further used to develop a new resistant variety for farmers in the future.
A Robust Secure Communication Protocol for Wireless Sensor Networks in Industrial Environments
Authors: Amara Nedra , Shoaib Muhammad Shoaib , Junaid Ahmed Junaid , Sayed Nasir Sayed 
Published: July 2023

Abstract
Wireless Sensor Networks (WSNs) have become a popular solution for monitoring and controlling industrial processes. However, these networks are vulnerable to security threats, such as eavesdropping, data tampering, node compromise, and denial of service attacks. To address these challenges, we propose a Robust Secure Communication (RISC) protocol that provides secure and reliable communication for industrial WSNs. In this article, we present the results of our experimental simulations and sensitivity analysis of the RISC protocol, which demonstrate its effectiveness in terms of performance and security. We also compare the RISC protocol with other state-of-the-art security protocols and discuss the strengths and limitations of each approach. Our findings highlight the robustness of the RISC protocol and its effectiveness in securing industrial WSNs against different types of security threats.
Application of Zeolite LTA towards Cherry Tomato (Solanum lycopersicum var. cerasiforme) on N Leaching and N utilised effectively
Authors: sazali Norsuhailizah , Harun Zawati 
Published: July 2023

Abstract
In numerous agriculturally intensive regions, nitrate leaching into groundwater is a significant concern. An experiment was conducted to determine the effects of cation-binding mineral zeolite hydrothermally synthesised from kaolin on nitrogen leaching, yield, and nitrogen absorption of cherry tomato in a pot. There are seven distinct experimental treatments; Control High (CH); Control Standard (CS); Control Low (CL); 2g of zeolite(2gZ); 4g of zeolite(4gZ); 6g of zeolite(6gZ); and 6g of industrial zeolite (6gIZ) grown in greenhouse with randomised design. In every treatment, drip irrigation with constant watering was applied. According to the results, 6g of zeolite demonstrates the smallest significant difference between the concentration mean values of nitrite and nitrate when compared to the other treatments. In terms of the average concentration of nitrogen in the soil at every harvest (harvest 1,2 and 3), 6g of zeolite added to the soil has the highest value compared to other treatments. There is no significant difference in fruit weight for all treatment, but 6g of zeolite results in the highest aggregate mean weight compared to other treatments. With its capacity as a CEC, zeolite was able to reduce the discharge of water from a container while increasing the average nitrogen concentration in the soil. The elevated CEC of zeolite also demonstrates an increase in cherry tomato weight.
Construction of an equidistant grid on an arbitrary curve
Authors: Volkmer Hans , Chugunova Marina , Ceely William J , Sawhney Raj 
Published: July 2023

Abstract
We consider a geometrical problem of existence of an equidistant set of $N$ points on non-closed and closed curves. For the non-closed curve we give a new version of the geometrical proof of the existence based on the continuous mapping argument. For a closed curve we construct a counterexample if the number of points $N$ is arbitrarily chosen and we give a proof of existence of the set if $N$ is taken sufficiently large. We develop a numerical algorithm that builds solutions for both types of curves.
MSC Classification: 00A69 , 55P10 , 65K10
Symptoms and problems reported by patients with non-cancer diseases through open-ended questions in specialist palliative care: A national register-based study
Authors: Rojas-Concha Leslye , Hansen Maiken Bang , Groenvold Mogens 
Published: July 2023

Abstract
Purpose
Since 2010, a comprehensive symptom/problem (S/P) assessment has been carried out in Danish specialist palliative care using the EORTC QLQ-C15-PAL questionnaire and the open-ended “Write In three Symptoms/Problems” (WISP) instrument. On WISP patients can report up to three S/Ps not included in the EORTC QLQ-C15-PAL. However, little is known about which S/Ps patients with non-cancer diseases report using WISP. Therefore, we investigated the prevalence and severity of S/Ps reported on WISP by non-cancer patients in specialist palliative care and compared these S/Ps with those previously reported by cancer patients.
Methods
This register-based study collected data from the Danish Palliative Care Database. We included adult patients with non-cancer diseases answering the EORTC QLQ-C15-PAL at admittance to specialist palliative care between 2016–2021. WISP responses were qualitatively categorized, and their prevalence and severity calculated.
Results
Of the 2,323 patients with non-cancer diseases answering the EORTC QLQ-C15-PAL, 812 (34.9%) reported at least one S/P using WISP. A total of 1,340 S/Ps were reported on WISP, of which 56.7% were not included in the EORTC QLQ-C15-PAL (i.e., were new). Edema, existential problems, dizziness, cough, and dysphagia were the most prevalent new S/Ps. Overall, 88.7% of the S/Ps were scored as moderate-severe. The prevalence of S/Ps reported on WISP did not significantly differ between cancer and non-cancer patients, except for existential problems, dysphagia, myoclonus, speaking problems, sweats and vomiting.
Conclusion
The similarities and differences in the prevalence of the most common S/Ps reported on WISP, confirm that WISP improves symptom assessment regardless of patient diagnosis.
ABS: Adaptive Bounded Staleness Converges Faster and Communicates Less
Authors: Tan Qiao , Zhu Feng , Zhang Jingjing , Liu Shengyun 
Published: July 2023

Abstract
The convergence time and communication rounds are critical performance metrics in distributed learning with a parameter-server (PS) setting. Local stochastic gradient descent (SGD) is a widely used method for improving communication efficiency in distributed learning. However, synchronous local SGD can experience substantial slowdowns, forcing stragglers to perform multiple local updates and the other nodes to keep waiting. Asynchronous methods are immune to these slowdowns but can suffer from gradient staleness, leading to suboptimal results or even divergence. To address these challenges, we propose a novel asynchronous strategy named adaptive bounded staleness (ABS). ABS leverages two key enablers. Firstly, the number of workers that the PS waits for per round for gradient aggregation is adaptively selected to strike a balance between straggling and staleness. Secondly, workers with relatively high staleness are prompted to initiate a new round of computation, alleviating the negative effects of staleness. Simulation results demonstrate that ABS outperforms state-of-the-art schemes in terms of wall-clock time and communication rounds.
Unraveling the Impact of SNAP on Household Non-Food Expenditure: An Instrumental Variables Approach
Authors: Almada Lorenzo , Nam Jaehyun 
Published: July 2023

Abstract
This study investigates the causal effects of SNAP participation on household expenditures, with a central focus on non-food related expenditures. We examine total non-food spending as well as six subcategories of non-food expenditures using the 2000–2011 waves of the Consumer Expenditure Survey (CE). Selection into SNAP is addressed by employing an IV approach that exploits variation in state-level policies and program administration to instrument for SNAP participation, conditional on household and state-level characteristics. Respondent misreporting is addressed by adopting an approach based on parametric methods for misclassified binary dependent variables that produces consistent estimates when using instrumental variables. The analyses reveal that, after adjusting for misreporting, SNAP participation among low-income households increases expenditure on non-food by 27 percent, while increasing expenditure on food by nearly 41 percent per year. The results indicate that SNAP participation significantly increases most of the non-food subcategories. The results are generally similar but measured less precisely when separately examining households with and without children. Overall, the findings of this study indicate that SNAP is serving its intended purpose of increasing household expenditures on food, while also allowing households to allocate some of their income to various non-food spending categories.
Preferential disruption of HLA-A/B enhances allogeneic CAR-T cell expansion and antitumor capacity in B cell malignancies
Authors: Chen Xinfeng , Tan Binghe , Xing Haizhou , Zhao Xuan , Ping Yu , Zhang Zhen , Huang Jianmin , Shi Xiujuan , Zhang Na , Lin Boxu , Cao Weijie , Li Xin , Zhang Xudong , Li Ling , Jiang Zhongxing , Zhang Mingzhi , Li Wei , Liu Mingyao , Du Bing , Zhang Yi 
Published: July 2023

Abstract
Background
Although chimeric antigen receptor T (CAR-T) cells have been proven to be an effective way of treating B cell malignancies, a lot of patients could not benefit from it because of failure in CAR-T cell manufacturing, disease progression and unaffordable price. The study aimed to explore universal CAR-T cell products to extend the clinical accessibility.
Methods
The antitumor activity of CRISPR/Cas9 edited allogeneic anti-CD19 CAR-T (CAR-T19) cells was assessed in vitro, in animal models, and in patients with relapsed/refractory (R/R) acute B cell lymphoblastic leukemia (B-ALL) or B cell lymphoma.
Results
B2M−/TRAC− universal CAR-T19 (U-CAR-T19) cells exhibited powerful anti-leukemia abilities both in vitro and in animal models, as did primary CD19+ leukemia cells from leukemia patients. However, expansion or anti-tumor efficacy of U-CAR-T19 cells was not observed in six patients with R/R B cell malignancies. Accordingly, significant activation of natural killer (NK) cells by U-CAR-T19 cells was proven both clinically and in vitro. HLA-A−/B−/TRAC− novel CAR-T19 (nU-CAR-T19) cells were constructed with similar tumoricidal capacity but resistance to NK cells in vitro. Surprisingly, robust expansion of nU-CAR-T19 cells, along with rapid eradication of CD19+ B cells, was observed in the peripheral blood and bone marrow of three patients with R/R B-ALL. The patients achieved complete remission with no detectable minimal residual disease 14 days after the infusion of nU-CAR-T19 cells. Two patients had grade 2 cytokine release syndrome, which was managed using an IL-6 receptor blocker. Most importantly, no graft-versus-host-disease was observed in any patient, suggesting the safety of TRAC-disrupted CAR-T cells generated using the CRISPR/Cas9 method for clinical application.
Conclusions
The "off-the-shelf" allogeneic nU-CAR-T19 cells showed a strong response in R/R B-ALL. nU-CAR-T19 cells have the potential to be a promising new approach for treating R/R B cell malignancies.
Multi-omics comprehensive analysis of renal clear cell carcinoma to distinguish subtypes with different molecular characterizations and therapeutic strategies
Authors: Ruan Xinjia , Lai Chong , Lu Xiaofan , Zhang Dandan , Lai Maode , Yan Fangrong 
Published: July 2023

Abstract
Purpose
Kidney renal clear cell carcinoma (KIRC) is the most prevalent heterogeneous subtype of malignant renal cell carcinoma and is well known as a common genitourinary cancer. Stratifying tumors based on heterogeneity is essential for better treatment options.
Methods
In this study, consensus clusters were constructed based on gene expression, DNA methylation, and gene mutation data, which were combined with multiple clustering algorithms. We further analyzed the gene differences, pathway enrichment, prognosis, genetic alterations, immunotherapy response and drug sensitivity of each subtype. In addition, we also performed integrated analysis of bulk data and scRNA-Seq data.
Results
Among the two identified subtypes, CS1 (consensus subtype) was enriched in more inflammation-related and oncogenic pathways than CS2, showing a worse prognosis. We found more copy number variations and BAP1 mutations in CS1. Although CS1 had a high immune infiltration score, it exhibited high expression of suppressive immune features. Based on the prediction of immunotherapy and drug sensitivity, we inferred that CS1 may respond poorly to immunotherapy and be less sensitive to targeted drugs. The analysis of bulk data combined with single-cell data further verified that the suppressive immune features were highly expressed in CS1 and the JAK STAT signaling pathway was enriched in CS1. Finally, the robustness of the new subtyping was successfully validated in four external datasets.
Conclusion
In conclusion, we conducted a comprehensive analysis of multi-omics data with 10 clustering algorithms to reveal the molecular characteristics of KIRC patients and validated the relevant conclusions by single-cell analysis and external data. Our findings discovered new KIRC subtypes and may further guide personalized and precision treatments.