bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enhanced Foldable Logarithmic Cycle Antenna
Authors: Zheng Hao , Zhu Zexi 
Published: March 2023

Abstract
Field communication and data transformation are critical in multiple geological surveys worldwide. However, antennas sold on the markets are mainly focused on their weight. These antennas may be destroyed by extreme weather like sandstorms. An enhanced foldable antenna based on SARRUS Linkage and Origami waterbomb pattern is designed to overcome external impacts. This research studies the basic unit of the SURRAS linkage to find the nobility of the structure. The comparison of the Origami technique waterbomb (WB), and split fold waterbomb pattern (SFWB) will discuss after the SARRUS linkage part. The basic unit of the SARRUS linkage has one degree of freedom. Subsequently, the kinematic model will demonstrate the deployment performance. Meanwhile, diagrams of the Origami waterbomb patterns illustrate the influence caused by the increasing number of folding angles, which is larger than the impact of the sector angle. This newly designed antenna has excellent protection and can effectively increase the workable area in which the antennas need to be deployed.
A GEANT4 based simulation framework for the large area muon telescope of the GRAPES-3 experiment
Authors: Varsi F. , Ahmad S. , Chakraborty M. , Chandra A. , Dugad S.R. , Goswami U.D. , Gupta S.K. , Hariharan B. , Hayashi Y. , Jagadeesan P. , Jain A. , Jain P. , Kawakami S. , Kojima H. , Mahapatra S. , Mishra S. , Mohanty P.K. , Moharana R. , Muraki Y. , Nayak P.K. , Nonaka T. , Oshima A. , Pant B.P. , Pattanaik D. , Pradhan A.K. , Pradhan G.S. , Rameez M. , Ramesh K. , Reddy L.V. , Saha S. , Sahoo R. , Scaria R. , Shibata S. , Zuberi M. 
Published: March 2023

Abstract
The GRAPES-3 experiment located in Ooty, India, samples the electron and muon components in extensive air showers using an array of plastic scintillator detectors and a muon telescope (G3MT) consisting of proportional counters to study the composition of primary cosmic rays (PCRs) as well as γ-ray sources in the TeV–PeV energy range. The G3MT is designed with an appropriate mass absorber to shield the electromagnetic and hadronic components in the shower and to detect muons above 1 GeV×sec(θ) energy, incident from a zenith angle θ. We developed a simulation framework based on the GEANT4 toolkit to evaluate the response of shower particles such as muons, γ-rays, electrons and hadrons in the G3MT. We discuss the geometric modeling of the G3MT using GEANT4 starting with the proportional counter. We estimated the punch-through contribution of hadrons in the G3MT. We compare the simulated muon multiplicity distributions with the observed ones assuming PCR composition from a four population supernova remnant acceleration model namely H4a.
Con-AAE: contrastive cycle adversarial autoencoders for single-cell multi-omics alignment and integration
Authors: Wang Xuesong , Hu Zhihang , Yu Tingyang , Wang Yixuan , Wang Ruijie , Wei Yumeng , Shu Juan , Ma Jianzhu , Li Yu 
Published: March 2023

AbstractMotivationWe have entered the multi-omics era and can measure cells from different aspects. Hence, we can get a more comprehensive view by integrating or matching data from different spaces corresponding to the same object. However, it is particularly challenging in the single-cell multi-omics scenario because such data are very sparse with extremely high dimensions. Though some techniques can be used to measure scATAC-seq and scRNA-seq simultaneously, the data are usually highly noisy due to the limitations of the experimental environment.ResultsTo promote single-cell multi-omics research, we overcome the above challenges, proposing a novel framework, contrastive cycle adversarial autoencoders, which can align and integrate single-cell RNA-seq data and single-cell ATAC-seq data. Con-AAE can efficiently map the above data with high sparsity and noise from different spaces to a coordinated subspace, where alignment and integration tasks can be easier. We demonstrate its advantages on several datasets.Availability and implementationZenodo link: https://zenodo.org/badge/latestdoi/368779433. github: https://github.com/kakarotcq/Con-AAE.
The Cyclic Diagnosability Of Hypercubes Under The PMC Model And The MM* Model
Authors: Zhang Hong , Zhou Shuming , Cheng Eddie 
Published: March 2023

Abstract
Motivated by a multitude of practical applications, many distinct vulnerability parameters of multiprocessor systems have been explored. Traditional connectivity and diagnosability are undoubtedly the most well investigated of these metrics, but often fail to capture the most subtle differences of a multiprocessor system. Subsequently, it is necessary to take into account the minimum degree of components, the size of components or the number of components. However, the structure of the components is ignored in these circumstances. In this work, we propose a novel diagnostic strategy based on cyclic connectivity, namely the cyclic diagnosability. The cyclic diagnosability, denoted by $ct(G)$, is the maximum size of the faulty vertex set $F$ of $G$ such that the self-diagnosable system $G$ can identify all the vertices in $F$ under the condition that at least two connected components of $G-F$ contain a cycle. Furthermore, we investigate the cyclic diagnosability of hypercube $Q_{n}$ under the PMC model and the MM* model, and show that $ct(Q_{n})=5n-10$ for $n\geq 7$.
State of charge and state of health estimation strategies for lithium-ion batteries
Authors: Wang Nanlan , Xia Xiangyang , Zeng Xiaoyong 
Published: March 2023

Abstract
Due to the widespread use of renewable energy sources, lithium-ion batteries have developed rapidly because renewable energy sources, such as photovoltaics and wind, which are very much affected by the environment and their power output can be better leveled if lithium-ion batteries are used. Battery state of charge (SOC) characterizes the remaining battery power, while battery state of health (SOH) characterizes the battery life state, and they are key parameters to characterize the state of lithium-ion batteries. In terms of battery SOC estimation, this paper optimizes the extended Kalman filtering (EKF) algorithm weights to adjust the weights during high current bursts to obtain better SOC tracking performance and optimizes the back propagation (BP) neural network for SOH estimation to obtain better weights to further obtain more accurate battery SOH. The feasibility of the optimized algorithm is validated by the experimental platform.
Genetic rescue remains underused for aiding recovery of federally listed vertebrates in the United States
Authors: Fitzpatrick Sarah W , Mittan-Moreau Cinnamon , Miller Madison , Judson Jessica M 
Published: March 2023

Abstract
Restoring gene flow among fragmented populations is discussed as a potentially powerful management strategy that could reduce inbreeding depression and cause genetic rescue. Yet, examples of assisted migration for genetic rescue remain sparse in conservation, prompting several outspoken calls for its increased use in genetic management of fragmented populations. We set out to evaluate the extent to which this strategy is underused and to determine how many imperiled species would realistically stand to benefit from genetic rescue, focusing on federally threatened or endangered vertebrate species in the United States. We developed a “genetic rescue suitability index (GR index)” based on concerns about small population problems relative to risks associated with outbreeding depression and surveyed the literature for 222 species. We found that two-thirds of these species were good candidates for consideration of assisted migration for the purpose of genetic rescue according to our suitability index. Good candidate species spanned all taxonomic groups and geographic regions, though species with more missing data tended to score lower on the suitability index. While we do not recommend a prescriptive interpretation of our GR index, we used it here to establish that assisted migration for genetic rescue is an underused strategy. For example, we found in total, “genetic rescue” was only mentioned in 11 recovery plans and has only been implemented in 3 of the species we surveyed. A potential way forward for implementation of this strategy is incorporating genetic rescue as a priority in USFWS recovery documentation. In general, our results suggest that although not appropriate for all imperiled species, many more species stand to benefit from a conservation strategy of assisted migration for genetic rescue than those for which it has previously been considered or implemented.
Gastrointestinal bleeding/ulcer among paediatric cancer patients after proton beam therapy
Authors: Fukushima Hiroko , Mizumoto Masashi , Suzuki Ryoko , Yamaki Yuni , Hosaka Sho , Inaba Masako , Tagawa Manabu , Watanabe Atsuko , Okunushi Tomoko , Masumoto Kouji , Muroi Ai , Sakurai Hideyuki , Takada Hidetoshi 
Published: March 2023

Abstract

Background
The details of gastrointestinal bleeding/ulcer in paediatric cancer patients treated with proton beam therapy have not been reported previously.

Methods
Patients aged 15 years or younger at the time of proton beam therapy and whose gastrointestinal tract was included in the irradiated field participated.

Results
A total of 124 patients participated in the study; their median age at irradiation was 5.4 years. Concurrent chemotherapies were vincristine–cyclophosphamide (16 patients), irinotecan-based treatment (16 patients), vincristine–cyclophosphamide–ifosfamide–etoposide (14 patients), other chemotherapy (27 patients) and no chemotherapy (51 patients). Gastrointestinal bleeding/ulcer occurred in four patients (3.2%), with no death due to the bleeding/ulcer. The sites of the gastrointestinal bleeding/ulcer were the stomach (two patients) and the duodenum (two patients). The ages of the four patients at PBT were 5.3, 13.8, 14.2 and 14.8 years, which were significantly older than those of patients without GI bleeding/ulcer (p = 0.017). The maximum irradiated doses to the GI tract in the four patients were 43.2, 45, 50.4 and 50.4 gray equivalent, respectively. The concomitant chemotherapy was vincristine–cyclophosphamide–ifosfamide–etoposide 3 and vincristine–cyclophosphamide 1. Weeks from proton beam therapy to bleeding/ulcer were 15, 20, 22 and 264.

Discussion and conclusions
Patients who developed gastrointestinal bleeding/ulcer were treated concurrently with vincristine–cyclophosphamide–ifosfamide–etoposide or vincristine–cyclophosphamide, and their ages were older than those of patients without gastrointestinal bleeding/ulcer. Bleeding occurred in the upper gastrointestinal tract in all the cases, and most cases occurred early and during chemotherapy. Upper gastrointestinal irradiation in older children undergoing intensive chemotherapy may increase the risk of developing gastrointestinal complications.
Hyponatremia as a Predictor of Cryptococcal Meningitis and Death Among Asymptomatic Persons With HIV and Cryptococcal Antigenemia
Authors: Lehman Alice , Nalintya Elizabeth , Wele Abduljewad , Kirumira Paul , Naluyima Rose , Namuli Teopista , Turya Musa Fred , Skipper Caleb P , Meya David B , Boulware David R , Rajasingham Radha 
Published: March 2023

Abstract
Among persons with human immunodeficiency virus–associated cryptococcal meningitis serum hyponatremia is a risk factor for mortality; however, the role of hyponatremia in persons with asymptomatic cryptococcal antigenemia is unknown. We found that serum hyponatremia ≤130 mmol/L is an independent risk factor for progression to meningitis and death in asymptomatic persons with cryptococcal antigenemia with low titers.
Severe Acute Respiratory Syndrome Coronavirus 2 Neutralizing Antibody Responses After Community Infections in Children and Adults
Authors: Dawood Fatimah S , Couture Alexia , Zhang Xueyan , Stockwell Melissa S , Porucznik Christina A , Stanford Joseph B , Hetrich Marissa , Veguilla Vic , Thornburg Natalie , Heaney Christopher D , Wang Jing , Duque Jazmin , Jeddy Zuha , Deloria Knoll Maria , Karron Ruth 
Published: March 2023

Abstract

Background
We compared postinfection severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) neutralizing antibody (nAb) responses among children and adults while the D614G-like strain and Alpha, Iota, and Delta variants circulated.

Methods
During August 2020–October 2021, households with adults and children were enrolled and followed in Utah, New York City, and Maryland. Participants collected weekly respiratory swabs that were tested for SARS-CoV-2 and had sera collected during enrollment and follow-up. Sera were tested for SARS-CoV-2 nAb by pseudovirus assay. Postinfection titers were characterized with biexponential decay models.

Results
Eighty participants had SARS-CoV-2 infection during the study (47 with D614G-like virus, 17 with B.1.1.7, and 8 each with B.1.617.2 and B.1.526 virus). Homologous nAb geometric mean titers (GMTs) trended higher in adults (GMT = 2320) versus children 0–4 (GMT = 425, P = .33) and 5–17 years (GMT = 396, P = .31) at 1–5 weeks postinfection but were similar from 6 weeks. Timing of peak titers was similar by age. Results were consistent when participants with self-reported infection before enrollment were included (n = 178).

Conclusions
The SARS-CoV-2 nAb titers differed in children compared to adults early after infection but were similar by 6 weeks postinfection. If postvaccination nAb kinetics have similar trends, vaccine immunobridging studies may need to compare nAb responses in adults and children 6 weeks or more after vaccination.
Constraints to and enablers for contextualizing digital health terminology standards in Uganda’s health services: a qualitative case study
Authors: Kiwanuka Achilles , Amiyo Mercy , Nabukenya Josephine 
Published: March 2023

ABSTRACTThis study investigated the constraints to and enablers for contextualizing digital health terminology standards using a case study approach of Uganda HIV services. Qualitative methods were used. The study was conducted at both the national and subnational levels of Uganda’s health system. Primary data were collected through key informant interviews, whereas secondary data were collected through document review. Twenty-one interviews were held at subnational levels among officers or their assistants including medical recorders, clinicians, nurses, laboratory technologists, pharmacists and administrators at health facilities and districts. Twelve interviews were held at the national level involving research institutions, academia, health development partners, health implementing partners, Ministry of Health and government agencies. The respondents were sampled purposively. Data were analysed using thematic analysis. The constraints to contextualizing digital health terminology standards were limited digital health terminology expertise, human resources deficits and inadequate information communication technology training. The enablers identified included presence of an installed base of established systems, digital health capacity-building endeavours and technical support at the health facilities. The study recommends that governments should invest in building capacities for digital health particularly training in terminology standards, with the vision of using uniform terminologies in health services across all levels of the health system. Constraints and enablers identified in this study informed our work of requirements generation and design of a framework for contextualizing digital health terminology standards for low- and middle-income countries like Uganda.
Trustworthiness, Responsibility and Virtue
Authors: Hills Alison 
Published: March 2023

Abstract
In the current philosophical literature on trustworthiness, two claims are very widely accepted, first that trustworthiness is a kind of reliability and secondly, that trustworthiness is not a virtue. Both claims are made, for instance, in Hawley's recent highly influential account of trustworthiness. I argue that both are mistaken. I develop and defend a new account of trustworthiness as responsibility, contrasting it with reliability and obligation accounts of trustworthiness. I argue that trustworthiness as responsibility is very plausibly a kind of moral virtue.
The Role of Cell Cycle Arrest Biomarkers for Predicting Acute Kidney Injury in Critically Ill COVID-19 Patients: A Multicenter, Observational Study
Authors: Weiss Raphael , von Groote Thilo , Ostermann Marlies , Lumlertgul Nuttha , Weerapolchai Kittisak , Garcia Manuel Ignacio Monge , Cano Jose Maria Martin , del Corral Beatriz Diez , Broch-Porcar María Jesús , Perez Carrasco Marcos , De la Vega Sanchez Arsenio , Sousa Eduardo , Catarino Ana , Roig Antonio Jorge Betbesé , Martinez de Irujo Jaume Baldira , de Rosa Silvia , de la Peña Manuel Garcia-Montesinos , Tomasa Teresa , Brivio Matteo , De Molina Francisco Javier Gonzalez , Gerss Joachim , Kellum John A. , Wempe Carola , Leidereiter Anna , Meersch Melanie , Zarbock Alexander 
Published: March 2023

OBJECTIVES:
Patients with COVID-19–associated acute respiratory distress syndrome (ARDS) have a high risk for developing acute kidney injury (AKI) which is associated with an increased risk of death and persistent renal failure. Early prediction of AKI is crucial in order to implement preventive strategies. The purpose of this study was to investigate the predictive performance of tissue inhibitor of metalloproteinases 2 and insulin like growth factor binding protein 7 (TIMP-2) × (IGFBP7) in critically ill patients with COVID-19–associated ARDS.

DESIGN:
Multicenter, prospective, observational study.

SETTING:
Twelve centers across Europe and United Kingdom.

PATIENTS:
Patients with moderate or severe COVID-19–associated ARDS were included and serial measurements of (TIMP-2) × (IGFBP7) were performed.

INTERVENTIONS:
None.

MEASUREMENTS AND MAIN RESULTS:
The primary endpoint was the development of moderate or severe AKI according to the Kidney Disease: Improving Global Outcomes definition. Three hundred patients were available for the primary analysis, and 39 met the primary endpoint. At enrollment, urinary (TIMP-2) × (IGFBP7) had high predictive value for the primary endpoint with an area under the receiver operating characteristic curve of 0.89 (95% CI, 0.84–0.93). (TIMP-2) × (IGFBP7) was significantly higher in endpoint-positive patients at enrollment and at 12 hours.

CONCLUSIONS:
Urinary (TIMP-2) × (IGFBP7) predicts the occurrence of AKI in critically ill patients with COVID-19–associated ARDS.
The origins of new SARS-COV-2 variants in immuncompromised individuals
Authors: Riddell Anna C. , Cutino-Moguel Teresa 
Published: March 2023

Purpose of reviewTo explore the origins of new severe acute respiratory coronavirus 2 (SARS-CoV-2) variants in immunocompromised individuals and whether the emergence of novel mutations in these individuals is responsible for the development of variants of concern (VOC).Recent findingsNext generation sequencing of samples from chronically infected immunocompromised patients has enabled identification of VOC- defining mutations in individualspriorto the emergence of these variants worldwide. Whether these individuals are the source of variant generation is uncertain. Vaccine effectiveness in immunocompromised individuals and with respect to VOCs is also discussed.SummaryCurrent evidence on chronic SARS-CoV-2 infection in immunocompromised populations is reviewed including the relevance of this to the generation of novel variants. Continued viral replication in the absence of an effective immune response at an individual level or high levels of viral infection at the population level are likely to have contributed to the appearance of the main VOC.
Comparison of Ectasia Detection in Early Keratoconus Using Scheimpflug-Based Corneal Tomography and Biomechanical Assessments
Authors: Wallace Henry B. , Vellara Hans R. , Gokul Akilesh , McGhee Charles N. J. , Meyer Jay J. 
Published: March 2023

Purpose:
The aim of this study was to determine the detection of keratoconus using corneal biomechanical parameters only, a corneal tomographic parameter only, and a parameter that combines corneal biomechanical and tomographic indices.

Methods:
The discriminatory power of the Pentacam Random Forest Index (PRFI), Belin/Ambrósio Enhanced Ectasia Display (BAD-D) index, Corvis Biomechanical Index (CBI), and Tomographic and Biomechanical Index (TBI) to differentiate between normal eyes (n = 84), eyes with very asymmetric corneal ectasia (VAE-E, n = 21), and the fellow eyes without apparent ectasia based on normal tomography (VAE-NT, n = 21) was assessed. Statistical analyses were completed with R software using t-tests, Wilcoxon rank sum tests, and receiver operating characteristic (ROC) curves. The DeLong test was used to compare the area under the ROC curve (AUROC).

Results:
The TBI and PRFI had the highest AUROC when distinguishing between normal and VAE-E corneas (AUROC = 1.00, 95% CI = 1.00–1.00); however, they were not statistically superior to the CBI (AUROC = 0.97, P = 0.27) or BAD-D (AUROC = 1.00, P = 0.34). The TBI (AUROC = 0.92, 95% CI = 0.86–0.98) was superior to CBI (AUROC = 0.78, P = 0.02) and BAD-D (AUROC = 0.81, P = 0.02) when distinguishing between healthy and VAE-NT corneas. At a threshold of 0.72, the TBI had 99% sensitivity, 67% specificity, and 92% accuracy in distinguishing normal and VAE-NT corneas.

Conclusions:
The TBI is a useful parameter for the screening of subclinical and frank keratoconus in tomographically normal eyes.
Clinical and laboratory studies on the effects of capsular tension ring on surgical outcomes of trifocal intraocular lens implantation
Authors: Sugita Toru , Aomatsu Masaru , Yoshida Masato , Kaneko Tsutomu , Hasegawa Yumi , Oshika Tetsuro 
Published: March 2023

Purpose:
To assess the influence of capsular tension ring (CTR) on surgical outcomes of trifocal intraocular lens (IOL) implantation in femtosecond laser-assisted cataract surgery.

Setting:
Sugita Eye Clinic, Tokyo, and University of Tsukuba, Ibaraki, Japan.

Design:
Prospective, randomized, paired-eye clinical study and laboratory study.

Methods:
In the clinical study involving 44 eyes of 22 patients with no risk of zonular instability, 1 eye received IOL alone and the contralateral eye received IOL with CTR. Preoperative capsular bag diameter and postoperative IOL tilt/decentration were measured using anterior segment optical coherence tomography. In the laboratory study, IOL and CTR were implanted into an artificial capsular bag of 10 mm in diameter, and IOL centration was evaluated.

Results:
Throughout the 12-month follow-up period, there was no significant difference in refractive and visual outcomes between groups. The amount of IOL decentration was significantly larger in eyes with CTR than in eyes without CTR at 12 months postoperatively (P = .037). There was a significant negative correlation between capsular bag diameter and the amount of IOL decentration in eyes with CTR (P = .038), but not in eyes without CTR (P = .873). The laboratory study indicated that interference between CTR eyelets and IOL haptics significantly increased IOL decentration (P < .001).

Conclusions:
The use of CTR did not affect refractive and visual outcomes of trifocal IOL implantation in eyes without the risk of zonular weakness. CTR coimplantation increased IOL decentration possibly due to the interference between CTR eyelets and IOL haptics.