bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effectiveness of Jian-Pi-An-Tai formula for the pregnancy outcome of in vitro fertilization and embryo transfer in infertile women: Protocol of a randomized controlled trial
Authors: Cheng Ran , Liu Qing , Zhu Ying , Zhao Ying , Yang Liuqing , Zhang Qin 
Published: December 2022

Introduction:
Infertility has become a global public health issue. In vitro fertilization and embryo transfer (IVF-ET) is widely performed as an infertility treatment. However, a significant number of infertile women continue to experience serial implantation failure, despite the high quality of the transferred embryos. Jian-Pi-An-Tai formula is an experience formula in treating threatened abortion in our team. It has also been used to treat infertile women after embryo transfer and shows superiority compared to single use of conventional western medicine. However, the of evidence on its effective in treating infertile women undergo IVF-ET is lacking.

Methods:
This randomized controlled trial (RCT) will be carried out in Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University planning to recruit 180 infertile patients undergoing IVF-ET with the type of deficiency of both the spleen and kidney. The control group will be treated by conventional western medicine and the treatment group will use conventional western medicine plus Jian-Pi-An-Tai formula. The primary outcomes will include Embryo implantation rate, Clinical pregnancy rate, Persistent pregnancy rate; and the secondary outcomes will include TCM symptom score and reproductive hormones. Safety evaluation will be recorded during the whole study. All data in this RCT will be analyzed by SPSS 23.0 software. This study has been approved by the Research Ethics Committee of the Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University (2022KY130).

Discussion:
The results of this RCT will contribute to provide scientific and rigorous evidence for the efficacy and safety of Jian-Pi-An-Tai formula in treating infertile women undergo IVF-ET. And the results from this RCT will be published in a relevant journal after finished.
The association between lifestyles and health conditions and the choice of traditional Chinese medical treatment in China: A latent class analysis
Authors: Ma Xueping , Wang Mohan , Ma Juan , Zhang Zhengjun , Hao Yu , Yan Ning 
Published: December 2022

Traditional Chinese medicine (TCM) plays a major role in preventing and treating the disease, however, it is also facing a slice of challenges as fewer choices of TCM treatment. Although lifestyles and health conditions might be paramount influencing factors for the choice of TCM treatment, the relative evidence is scarce. The current observational study was designed to evaluate this association.
A total of 24,173 Chinese individuals with a mean age of 47.3 years from the Chinese Family Panel Studies 2014 were selected. The choice of TCM treatment was acquired by the self-report questionnaire. Latent class analysis was employed to identify clusters of lifestyles and health conditions. The binary logistic regression model was employed to examine the association between lifestyles, health conditions and the choice of TCM treatment.
Lifestyles and health conditions were classified into 3 classes with latent class analysis, healthy group, unhealthy behavior group, and physical inactivity group. After controlling for potential confounding factors, the results showed individuals in unhealthy behavior group (odds ratio = 1.51, 95% confidence interval: 1.35–1.68, P < .001) or physical inactivity group (odds ratio = 1.11, 95% confidence interval: 1.02–1.22, P = .019) were more likely to visit TCM doctors than healthy group. Sex-specific difference was observed, the relationship still existed among the males.
The current study revealed the relationship between lifestyles, health conditions and the choice of TCM treatment. This will provide evidence for the TCM development and provide support for further research.
Connective tissue disease with macrophage activation syndrome: A case report
Authors: Chen Qu , Zhang Qiushuang , Wang Xuebin 
Published: December 2022

Rationale:
Macrophage activation syndrome (MAS), or secondary hemophagocytic lymphocytosis (sHLH), is a rare systemic inflammatory response syndrome that is fatal. Adult patients lack clear criteria for diagnosis and treatment, primarily derived from guidelines and protocols for treating family hemophagocytic lymphocytosis and systemic juvenile idiopathic arthritis (sJIA)-related MAS in children or from retrospective case reports. As a subtype of sHLH, MAS has a clinical presentation like sHLH, but treatment varies. Herein, we report the case of a 40-year-old female with MAS caused by a connective tissue disease.

Patient concerns:
The patient presented to the Rheumatology and Immunology Clinic with recurrent fever and rash, and MAS was confirmed after a series of examinations. The patient had no significant effect after treatment with JAK inhibitors, but after the use of the IL-6 inhibitor tocilizumab, the fever and rash were significantly reduced, and laboratory indicators returned to normal levels.

Diagnosis:
Considering the patient’s condition and laboratory test results, we judged that the patient had connective tissue disease with MAS.

Interventions:
We gave sequential treatment of tocilizumab.

Outcomes:
ALL indicators are mostly back to normal when the patient was monitored at the outpatient clinic.

Lessons:
MAS/HLH lacks clear criteria for diagnosis or treatment in adult patients and is extremely difficult to distinguish from bacterial sepsis or other systemic inflammatory response syndromes. Consequently, early diagnosis and treatment are indispensable for enhancing patient survival.
Metagenomic next-generation sequencing as an unconventional approach to warn of tumor cells in a patients with non-mucinous pneumonic-type lung adenocarcinoma: Case report
Authors: Shui Yuexiang , Wang Huabin 
Published: December 2022

Rationale:
Pneumonic-type lung cancer (PTLC) is a special type of lung cancer with cough and expectoration as the main clinical symptoms and inflammatory signals as the main imaging manifestations. PTLC can be easily misdiagnosed as pneumonia, and the diagnosis and treatment are always delayed. Metagenomic next-generation sequencing (mNGS), as an emerging and effective method to identify occult pathogens, has been gradually adopted by clinicians.

Patient concerns:
A 58-year-old woman with recurrent cough and expectoration was admitted to hospital on January 12th, 2022. She reported that she was diagnosed with pneumonia half a month ago, after treatment with expectorant and antibiotics for 5 days, the symptoms were relieved. However, the symptoms worsened again 10 days after stopping the drugs. On the current presentation, she denied exposure to patients with infection of COVID-19, smoking history, night sweats, weight loss, rash, joint pain, fever, and shortness of breath.

Diagnoses:
The patient was diagnosed with non-mucinous pneumonic-type lung adenocarcinoma according to the clinical symptoms, changes of CT scans after treatment and cytopathology examinations.

Interventions and outcomes:
The patient was initially diagnosed with pulmonary infection according to computerized tomography (CT) scan. Expectorant and antibiotics used. However, the symptoms worsened again 10 days after stopping the drugs. On her return visit, the CT scan did not showed obvious consolidation absorption and was similar to the previous imaging findings. mNGS was performed to detect the occult pathogens. None pathogen was detected, however, 39 copy number variations were found in Human Chromosomal Instability Analysis of mNGS indicating the presence of tumor cells. The cytopathology findings confirmed the presence of lung adenocarcinoma (non-mucinous adenocarcinoma). She was treated with targeted antitumor drugs, and the CT scan after 20 days of targeted antitumor therapy showed obvious absorption of the lesions.

Lessons:
mNGS may have potential value to screen tumor cells in bronchoalveolar lavage fluid of patients with PTLC, especially in the patients whose samples in bronchioli cannot be collected using existing sampling tools.
The first case of bipolar transurethral resection of the prostate for giant prostatic hyperplasia: A case report
Authors: Cui Deheng , Chen Guoqiang , Luo Jianbin , Zhang Minjie 
Published: December 2022

Rationale: We admitted an 89-year-old male patient diagnosed with benign prostatic hyperplasia and a prostate volume of approximately 522 ml measured by magnetic resonance imaging.
Patient concerns: He had previous hypertension, diabetes, and coronary artery disease.
Diagnoses: Giant prostatic hyperplasia.
Interventions: We opted for bipolar transurethral resection of the prostate (BTURP).
Outcomes: The urinary flow rate was detected 1 week after surgery, with a peak flow rate of 17 mL/s and a voided volume of 156 mL. The follow-up was 11 months, with an international prostate symptom score of 7 and a quality of life (QOL) of 1.
Conclusion: Complete removal of the prostate is not our goal; reducing the risk of surgery and improving the quality of life of the patient is the theme.
Synchronous isolated gastric metastases from ascending colon carcinoma: A case report
Authors: Yang Bin , Gan Zhonghua , Liu Shulan , Si Guangyan 
Published: December 2022

Background:
Gastric metastases (GMs) are rare and often accompanied with synchronous metastases of other organs. Synchronous isolated GMs from ascending colon carcinoma are uncommon and rarely studied. GMs may be confused with primary gastric tumors.

Methods:
A 45-year-old man presented to our hospital with abdominal distension
and anal pendant expansion. The abdominal physical examination was negative. The positive fecal occult blood test and the negative tumor marker were obtained. Colonoscopy and gastroduodenoscopy revealed a polypoidal lesion in the ascending colon and a polypoid mass in the gastric body, respectively. CT showed the thickened wall of ascending colon and polypoid mass in the gastric body with homogenous enhancement. Additionally, synchronous gastric metastases from the ascending colon carcinoma were confirmed by pathology after laparoscopic right hemicolectomy and partial gastrectomy. After 13 individual doses of fluorouracil (2.8 g/time), calcium leucovorin (0.8 g/time), and oxaliplatin (85 mg/time), the patient was discharged without any discomfort, without any additional metastases detected during the following 18 months.1.

Results:
A rare case of synchronous isolated gastric metastasis from ascending colon carcinoma was confirmed by computed tomography (CT) and pathological diagnosis.

Conclusion:
GM may appear as a polypoid lesion. Surgery combined with chemotherapy may improve the prognosis in patients with synchronous isolated GM.
Anxiety and depression among pregnant women undergoing IVF-ET and WeChat group peer support during the COVID-19 pandemic: Study protocol for a randomized controlled trial
Authors: Cao Jing-Xian , Jiang Wen-Jing , Yan Meng-Han , Wang Dan-Dan , Hou Jin-Wei , Song Jing-Yan , Sun Zhen-Gao 
Published: December 2022

Introduction:
The psychological well-being of pregnant women following assisted reproductive has increasingly gained attention in recent years. Anxiety and depression may be associated to pregnancy outcomes. This study aims to determine whether peer support and the WeChat group platform will reduce anxiety and depression among in vitro fertilization and embryo transfer (IVF-ET) women.

Methods and Analysis:
In the present randomized controlled study, 296 patients with confirmed clinical pregnancy following IVF-ET will be randomly assigned to receive standard intervention support or WeChat peer support on a 1:1 basis. The levels of anxiety and depression are the primary endpoints. Assessments will be performed at baseline measurements, first trimester, second trimester, and third trimester, and data will be collected.

Ethics and Dissemination:
This study has been approved as ethical by the affiliated hospital of Shandong University of Traditional Chinese Medicine’s Reproductive Ethics Committee. Each patient will sign a written statement of informed permission. All information and biological samples will be legally protected. A peer-reviewed academic journal will publish the findings of this investigation.

Discussion:
Given the inconvenience of visits due to the current pandemic of COVID-19, this study addresses the patient’s visit needs by combining WeChat, the most widely used social software in China, with peer support, while helping improve maternal anxiety, depression, and pregnancy outcomes following IVF-ET.
Perineal burn injury with hidradenitis suppurativa: A case report
Authors: Wang Linyue , Qi Wenyue , Gao Jihua , Tian Maosheng , Sun Hongyuan , Xu Wencong 
Published: December 2022

Rationale:
Hidradenitis suppurativa (HS) is a chronic, inflammatory skin disease which usually presents with painful, deep-seated, inflamed lesions in the apocrine gland-bearing areas. Severe HS has interconnecting sinus tracts and when it occurs in the perianal region, perianal fistulas can form. Obesity and smoking are 2 risk factors for the development of HS.

Patient concerns:
We report a case of a 33-year-old male diagnosed with perianal HS and perianal fistula following a burn injury to the area that occurred during childhood.

Diagnosis:
Through integration of the clinical signs and imaging results, the patient was diagnosed with HS, Hurley stage III with perianal fistulas.

Interventions:
The patient accepted surgical therapy. Performed under the general anesthesia, the procedure comprised sinus tracts excision and drainage.

Outcomes:
The patient was discharged from the hospital 6 weeks after surgery.

Lessons:
The pathogenesis of the HS in this case was the burn injury interfering with sweat gland formation around the anus. Moreover, the scar from the burn made surgical treatment difficult.
Risk factors for inadequate bowel preparation in patients using high- and low-volume cleansing products
Authors: Occhipinti Vincenzo , Soriani Paola , Vavassori Sara , Annunziata Maria Laura , Bagolini Francesco , Cavallaro Flaminia , Lagoussis Pavlos , Milani Valentina , Rondonotti Emanuele , Spina Luisa , Vecchi Maurizio , Pastorelli Luca , Tontini Gian Eugenio 
Published: December 2022

Introduction
Bowel preparation is crucial for colonoscopy completeness and lesions detection. Today, several cleansing products are equally recommended by guidelines, irrespective of patients’ characteristics. Identification of preparation-specific risk factors for inadequate bowel preparation may lead to a personalized prescription of cleansing products to refine patients’ tolerance and improve endoscopic outcomes.

Methods
We prospectively enrolled consecutive outpatients referred for colonoscopy using either a high-volume [HV: 4 l polyethylene glycol (PEG)] or a low-volume (LV: 2 l PEG + bisacodyl) preparation. Day-before regimen or split-dose regimen was used for morning or afternoon colonoscopies, respectively. Univariate and multivariate analyses were conducted to identify risk factors related to inadequate bowel preparation, according to the Boston bowel preparation scale for HV and LV preparations.

Results
We enrolled 2040 patients, of which 1815 were included in the final analysis (average age 60.6 years, 50.2% men). Half of them (52%) used LV preparation. Adequate preparation was achieved by 87.6% without differences between the HV and LV groups (89.2% vs. 86.6%; P = 0.098). The use of day-before regimen and incomplete assumption of PEG were independent predictors of poor visibility for either HV or LV preparation. However, different specific risk factors for HV [diabetes: odds ratio (OR), 3.81; 95% confidence interval (CI), 1.91–7.58; low level of instruction: OR, 1.95; 95% CI, 1.11–3.44; and previous abdominal surgery: OR, 2.27; 95% CI, 1.20–4.30] and for LV (heart disease: OR, 2.06; 95% CI, 1.09–3.88; age > 65 years: OR, 1.51; 95% CI, 1.01–2.27) preparations were identified.

Conclusion
Day-before preparation and incomplete assumption of the purgative agents affect bowel visibility irrespective of the preparation volume. LV should be preferred to HV preparations in patients with diabetes, low level of instruction, and previous abdominal surgery, whereas an HV preparation should be preferred in patients with heart disease and in older patients.
Celiac Disease Frequency Is Increased in IgE‐Mediated Food Allergy and Could Affect Allergy Severity and Resolution
Authors: Lega Sara , Badina Laura , De Leo Luigina , Andrade Stefanny , Ziberna Fabiana , Gaita Bartolomea , Di Leo Grazia , Bramuzzo Matteo , Barbi Egidio , Not Tarcisio , Berti Irene 
Published: December 2022

Objectives:An increased frequency of celiac disease (CeD) has been reported in severe Immunoglobulin E (IgE) ‐mediated food allergy (FA). This observation requires confirmation, and whether CeD affects FA severity and resolution is unknown. The study aims to estimate the prevalence of CeD in patients with FA and to investigate whether CeD affects FA severity and oral tolerance.Methods:Consecutive patients with FA referred for allergen reintroduction, either to evaluate allergy resolution or to start oral immunotherapy (OIT), were evaluated for CeD and for FA severity. The primary outcome was the prevalence of CeD. Secondary outcomes were the frequency of severe FA and the level of clinical tolerance at study entry and at last follow‐up in patients with isolated FA versus patients with FA + CeD.Results:Two hundred twenty‐eight patients were included. CeD was confirmed in 15 patients (6.6%) of whom, 8 patients had a previously established diagnosis of CeD and were on a gluten‐free diet. Severe FA was observed in 12 patients with FA + CeD (80%) versus 88 patients with FA (42%) (P = 0.006). At baseline, patients with FA + CeD had significantly higher median allergen‐specific IgE levels [61.8 kU/L; interquartile range (IQR) 11.6–279.0] compared to patients with FA (20.3 kU/L; IQR 2.9–72.7) (P < 0.001). Complete clinical tolerance was observed in 1 of 15 patients (7%) with FA + CeD versus 98 of 205 patients (48%) with FA (P = 0.002).Conclusions:CeD is highly prevalent in patients with FA and could affect FA severity and response to OIT. CeD screening should be considered in patients with severe or persistent FA.
What Makes A “Successful” Kasai Portoenterostomy “Unsuccessful”?
Authors: Matcovici Melania , Stoica Ionica , Smith Kristy , Davenport Mark 
Published: December 2022

Objectives:Clearance of jaundice (CoJ) is the first key objective of Kasai portoenterostomy (KPE) for biliary atresia (BA) and its achievement is by far the best index of long‐term prognosis. We sought to identify the reasons for failure [subsequent liver transplant (LT)] in this cohortMethods:Review of single‐center prospective BA database. Successful KPE was defined by achieving a postoperative bilirubin of ≤20 µmol/L. Pre‐KPE and post‐KPE variables were identified together with a multivariate logistic regression model to identify those observable at 3 months post‐KPE. Data are quoted as median (range). A P value of ≤0.05 was significant.Results:One hundred thirty‐five infants underwent KPE between January 2012 and December 2018, of which 90 (67%) achieved CoJ. From these 20 (22%) (Cohort A) underwent LT with the remainder continuing with native liver (Cohort B) (median follow‐up of 4.15 years). There was no difference in age at KPE (P = 0.41), APRi (aspartate aminotransferase‐to‐platelet ratio) (P = 0.07), associated anomalies (P = 0.7), and cytomegalovirus status (P = 0.7) between the 2 groups. Postoperatively, both cholangitis [any episode, 18/20 (90%) vs 15/70 (21%); P < 0.0001] and portal hypertension (PHT) [gastrointestinal (GI) bleed, 10/20 (50%) vs 2/70 (2.8%); P < 0.0001] were significantly more common in cohort A. Univariate analysis showed that the most significant predictive values at 3 months for LT by 2 years were high APRi, bilirubin, international normalized ratio, and ultrasound (US)‐detected ascites with multivariate logistic modeling confirming these variables with predictive values of r2 = 0.79, AUROC = 0.98.Conclusions:Failure is not preordained at KPE but due to recurrent cholangitis and/or symptoms of PHT.
Novel Use of Time-Resolved Magnetic Resonance Angiography to Evaluate Retrograde Lumbar Vein Flow and Epidural Venous Plexus Enhancement in Chronic Headache Patients With and Without Nutcracker Physiology
Authors: Devcic Zlatko , Rozen Todd , Arora Manasi , Caserta Melanie P. , Montazeri S. Ali , Erben Young M. , Sandhu Sukhwinder S. , Huynh Thien , Lewis Andrew R. , Malik Komal , Toskich Beau 
Published: December 2022

Objective
Compression of the left renal vein by the superior mesenteric artery, known as nutcracker phenomenon (NCP), can cause retrograde flow and congestion in communicating venous systems. It has recently been speculated that NCP can result in retrograde flow and congestion of the lumbar veins and epidural venous plexus (EVP), thereby affecting the central nervous system. This study describes the novel use of time-resolved magnetic resonance angiography (trMRA) to evaluate for retrograde left second lumbar vein (L2LV) flow and early EVP enhancement in patients with chronic daily headache (CDH) with and without NCP.

Methods
A retrospective analysis was performed of 31 patients with CDH (27 females and 4 males; median age, 38 years [range, 18–63 years]) who underwent trMRA centered over the L2LV to evaluate the direction of blood flow and presence of early EVP enhancement from May 2020 to March 2022. Descriptive statistics were performed, and anatomic associations were analyzed in patients with and without retrograde L2LV flow and early EVP enhancement. The accuracy of magnetic resonance imaging findings in detecting these flow patterns was also assessed.

Results
Patients with NCP who demonstrated narrowing of the left renal vein, a positive beak sign (P = 0.052), decreased aortomesenteric distance (P = 0.038), and decreased SMA angle demonstrated increased rates of retrograde L2LV flow and early EVP enhancement. A positive beak sign was 83% specific, and an aortomesenteric distance of ≤6.5 mm was 61% sensitive and 83% specific for identifying retrograde L2LV flow with early regional EVP enhancement in patients with CDH.

Conclusions
Retrograde L2LV flow with early EVP enhancement in CDH patients can be effectively evaluated using trMRA and was seen with greater propensity in those patients with NCP.