bluuebunny/crossref_metadata_2025_split huggingface dataset:
Complementary and alternative medicine use by pregnant women in Japan: a pilot survey
Authors: Watanabe Ayana , Inoue Satomi , Okatsu Aiko , Eto Hiromi , Oguro Michiko , Kataoka Yaeko 
Published: August 2023

Abstract
Background
Complementary and alternative medicine (CAM) are popular among women, and are used during their pregnancy in Japan. This study aimed to survey the prevalence of CAM use by healthy pregnant women as a health-care prescribed therapy or self-care and to investigate the factors associated with CAM use in Japan.

Methods
In this cross-sectional study, pregnant women after 34 weeks of gestation were asked to respond to a questionnaire at the clinic or online. The questionnaire comprised questions on the participants’ characteristics and their use of CAM for therapy and self-care. Descriptive statistics were calculated in the analyses, and bivariate and multivariate logistic analyses were performed to evaluate the associations between factors and CAM use.

Results
A total of 394 women responded from three hospitals, two clinics, and two midwifery birth centers. CAM was received as treatment by practitioners during pregnancy by 75 women (19.0%). The following therapies were used: traditional Chinese medicine (7.9%), chiropractic (6.9%), moxibustion (6.4%), and acupuncture (5.3%). One or more types of therapy were used as self-care by 348 women (88.3%). Highly used CAM for self-care were: folic acid supplementation (75.4%), other supplements (51.5%), herbs (20.8%), and yoga (19.0%). Multiple logistic regression analyses revealed that the factors associated with CAM use as a therapy were midwifery birth centers for planned childbirth settings (adjusted odds ratio [AOR] 3.64, 95% confidence interval [CI] [1.69–7.83]) and pregnancy complications diagnosed (AOR 2.46, 95%CI [1.38–4.39]). The factors associated with CAM use for self-care were age 30–39 years (AOR 4.48, 95%CI [2.14–9.73]) and over 40 years (AOR 3.92, 95%CI [1.10–13.91]), junior college education or above (AOR 2.30, 95%CI [1.18–4.51]), and primiparas (AOR 3.82, 95%CI [1.86–7.86]). The most common source of information was the “Internet” (43.8%).

Conclusions
Approximately 20% of Japanese pregnant women received CAM as therapy by practitioners, and the related factors were: tended to have baby at midwifery birth center and pregnancy complications. Almost 90% of respondents used CAM as self-care and the related factors were: older, had a higher educational level and tended to be primiparas. They used the Internet as their main source of information about CAM. Health care providers need to provide evidenced-based information on CAM and to help decision making to ensure safe and effective CAM utilization by pregnant women.
Advances in nanomedicines for lymphatic imaging and therapy
Authors: He Pan , Tang Haitian , Zheng Yating , Xiong Yongfu , Cheng Hongwei , Li Jingdong , Zhang Yang , Liu Gang 
Published: August 2023

AbstractLymph nodes play a pivotal role in tumor progression as key components of the lymphatic system. However, the unique physiological structure of lymph nodes has traditionally constrained the drug delivery efficiency. Excitingly, nanomedicines have shown tremendous advantages in lymph node-specific delivery, enabling distinct recognition and diagnosis of lymph nodes, and hence laying the foundation for efficient tumor therapies. In this review, we comprehensively discuss the key factors affecting the specific enrichment of nanomedicines in lymph nodes, and systematically summarize nanomedicines for precise lymph node drug delivery and therapeutic application, including the lymphatic diagnosis and treatment nanodrugs and lymph node specific imaging and identification system. Notably, we delve into the critical challenges and considerations currently facing lymphatic nanomedicines, and futher propose effective strategies to address these issues. This review encapsulates recent findings, clinical applications, and future prospects for designing effective nanocarriers for lymphatic system targeting, with potential implications for improving cancer treatment strategies.
Calcineurin stimulation by Cnb1p overproduction mitigates protein aggregation and α-synuclein toxicity in a yeast model of synucleinopathy
Authors: Chawla Srishti , Ahmadpour Doryaneh , Schneider Kara L. , Kumar Navinder , Fischbach Arthur , Molin Mikael , Nystrom Thomas 
Published: August 2023

AbstractThe calcium-responsive phosphatase, calcineurin, senses changes in Ca2+concentrations in a calmodulin-dependent manner. Here we report that under non-stress conditions, inactivation of calcineurin signaling or deleting the calcineurin-dependent transcription factorCRZ1triggered the formation of chaperone Hsp100p (Hsp104p)-associated protein aggregates inSaccharomyces cerevisiae. Furthermore, calcineurin inactivation aggravated α-Synuclein-related cytotoxicity. Conversely, elevated production of the calcineurin activator, Cnb1p, suppressed protein aggregation and cytotoxicity associated with the familial Parkinson’s disease-related mutant α-Synuclein A53T in a partlyCRZ1-dependent manner. Activation of calcineurin boosted normal localization of both wild type and mutant α-synuclein to the plasma membrane, an intervention previously shown to mitigate α-synuclein toxicity in Parkinson’s disease models. The findings demonstrate that calcineurin signaling, and Ca2+influx to the vacuole, limit protein quality control in non-stressed cells and may have implications for elucidating to which extent aberrant calcineurin signaling contributes to the progression of Parkinson’s disease(s) and other synucleinopathies.
Identification and characterization of a polyomavirus in the thornback skate (Raja clavata)
Authors: Abrantes Joana , Varsani Arvind , Pereira Paulo , Maia Catarina , Farias Inês , Veríssimo Ana , Neves Fabiana 
Published: August 2023

AbstractMembers of the family Polyomaviridae have a circular double-stranded DNA genome that have been identified in various hosts ranging from mammals to arachnids. Here we report the identification and analysis of a complete genome sequence of a novel polyomavirus, Raja clavata polyomavirus (RcPyV1), from a cartilaginous fish, the thornback skate (Raja clavata). The genome sequence was determined using a metagenomics approach with an aim to provide baseline viral data in cartilaginous fish in different ecosystems. The RcPyV1 genome (4,195 nucleotides) had typical organization of polyomavirus, including early antigens (small T; Large T) encoded on one strand and late viral proteins (VP1; VP2) on the complementary strand. Maximum-likelihood phylogenetic analysis of the large T-antigen revealed that RcPyV1 clusters with a polyomavirus obtained from another cartilaginous fish, the guitarfish polyomavirus 1 (GfPyV1). These two share ~ 56% pairwise identity in LT and VP1 protein sequences. These analyses support the hypothesis that cartilaginous fishes have a specific lineage of polyomaviruses.
Soil bacterial community composition is more stable in kiwifruit orchards relative to phyllosphere communities over time
Authors: Louisson Ziva , Ranjard Louis , Buckley Hannah L. , Case Bradley S. , Lear Gavin 
Published: August 2023

Abstract
Background
Soil and phyllosphere (leaves and fruit) microbes play critical roles in the productivity and health of crops. However, microbial community dynamics are currently understudied in orchards, with a limited number incorporating temporal monitoring. We used 16S rRNA gene amplicon sequencing to investigate bacterial community temporal dynamics and community assembly processes on the leaves and fruit, and in the soil of 12 kiwifruit orchards across a cropping season in New Zealand.

Results
Community composition significantly differed (P < 0.001) among the three sample types. However, the communities in the phyllosphere substrates more closely resembled each other, relative to the communities in the soil. There was more temporal stability in the soil bacterial community composition, relative to the communities residing on the leaves and fruit, and low similarity between the belowground and aboveground communities. Bacteria in the soil were more influenced by deterministic processes, while stochastic processes were more important for community assembly in the phyllosphere.

Conclusions
The higher temporal variability and the stochastic nature of the community assembly processes observed in the phyllosphere communities highlights why predicting the responsiveness of phyllosphere communities to environmental change, or the likelihood of pathogen invasion, can be challenging. The relative temporal stability and the influence of deterministic selection on soil microbial communities suggests a greater potential for their prediction and reliable manipulation.
Sustainable approaches for the synthesis of biogenic platinum nanoparticles
Authors: Malode Ulka , Patil Yamini S. , Selokar Yajurved Narhari , Yadav Pratima R. , Bhagat Rupali Patil , Nikose Vibha M. , Thakare Rakesh U. , Nimbarte Seema 
Published: August 2023

AbstractBackgroundThe era of nanotechnology become widespread for research and human resource development due to its functionalized tuning with economical, eco-friendly, effective and sustainable end-products. Hence, the present review illustrates the biogenic fabrication of platinum nanoparticles (PtNPs) through the different sustainable and cheaper approaches.Main body of the abstractOver the physicochemical-based nanotechnology, the biogenic active substances-based synthesis displayed the more promising candidature due to its non-toxic, Broad-spectrum applicability and defendable type character. The biogenic synthesis method is capable with and without capping and highly motif of reducing agents. The morphology and stability of synthesized PtNPs are mostly mediated by various experimental conditions such as pH, temperature, incubation time, concentrations of biomaterials and salts or enzymes used. Hence, the review is aiming to discuss the methodology of biogenic synthesis of PtNPs by plant stem, root, leaf, flower, fruit, extracts, algae, fungi and egg yolk. Also, we have illustrated the pharmaceutical drug model application and its adverse effect.Short conclusionSynthesized PtNPs are open a new trend in catalyst, drug and its carrier and in cancer treatment. PtNPs are utilized as a new therapeutic agent for inhibiting the microbial pathogens with non-toxic behavior. The characterization of PtNPs could estimate the bio-sensitized properties which leads the commercial applications.
Selection of Control Tasks for Students Using Neural Networks and Multi-Criteria Optimization
Authors: Koncova T. , Dogadina E. , Bocharov M. 
Published: August 2023

One of the most important parameters of a student’s progress is the correct selection of control tasks when conducting an intermediate cut of knowledge. This paper proposes the optimal compilation of test tasks, taking into account their complexity, duration of execution, the number of questions in the task, the number of topics covered and the actions required to complete the task. Since each student is individual, the question arises of the correctness of providing the same control task to students with different mental and psycho-emotional characteristics. Therefore, the optimal compilation of tasks for a particular student is quite relevant. This study will improve the student’s progress and success in general, and will also remove a number of responsibilities from the teacher related to the generation of topics and tasks when compiling the test.
The paper proposes to develop a hybrid system of multi-criteria optimization with two fully connected neural networks, which allows determining the most suitable model for compiling a task of control work based on a number of features of a particular student.
When a close person suddenly changes their behavior – dementia in young people. A case report
Authors: Wiśniewska-Skomra Joanna , Tylutka Kinga , Hapon Anna , Zapała Magdalena , Hunek Adrian , Kaziród Karolina , Chmielarz Karolina , Dadziak Mikołaj 
Published: August 2023

The aim of our study is to present a case report of a young patient with rapidly progressive behavioral changes. A 39-year-old well functioning man in a short period of time began to show symptoms like agressive towards his family members, binge eating, apathy, difficulties with social interactions, reduced verbal fluency and poverty of speech, disorders in executive functions and restlessness and anxiety. This behavioral changes appeared in a short period of time (6 months). The concerned family, alarmed by this unusual behavior not previously observed, sought medical help. The patient was disoriented, not receptive to arguments about his atypical behavior, and unaware of the existing problem. A comprehensive diagnostic evaluation (including laboratory, imaging, and neuropsychological assessments) was conducted during the hospital stay. MRI scan showed substantial cortical atrophy in frontal and temporal lobes. Based on the clinical status, typical MRI and neuropsychological examination, the patient was diagnosed with frontotemporal dementia (FTD).
The patient received a diagnosis in a very short period of time, which is not typical in establishing a diagnosis for this particular medical condition. The symptoms are often nonspecific, which delays the diagnosis or leads to an incorrect preliminary diagnosis of another medical condition. Difficulties in diagnosing also arise from the non-specific symptoms, which are often overlooked by the patient themselves. It is important to emphasize the crucial role of family members and close associates in recognizing the initial symptoms and making attempts to diagnose the disease. It is also important to provide support and care for the patient's family, for whom the diagnosis of FTD becomes challenging and burdening.
Effect of optional biometric parameters in the Kane formula on intraocular lens power calculation
Authors: Li Xiao-Yu , Liao Xuan , Lin Jia , Lan Chang-Jun , Tan Qing-Qing 
Published: August 2023

Purpose
To investigate the effect of the optional biometric parameters lens thickness (LT) and center corneal thickness (CCT) in the Kane formula on intraocular lens (IOL) power calculation.

Methods
A cross-sectional study included consecutive cataract patients who received uncomplicated cataract surgery with IOL implantation from May to September 2022 were enrolled. The ocular biometric parameters were obtained using IOLMaster 700 and then inputted into online Kane formula calculator. The IOL power was calculated for targeting emmetropia and compared between groups: not omitting (NO) group, omitting LT and CCT (OLC) group, omitting LT (OL) group and omitting CCT (OC) group. Further, according to the axial length (AL), anterior chamber depth (ACD), and mean keratometry (Km), the eyes were divided into three subgroups, respectively.

Results
1005 eyes of 1005 consecutive patients were included. There was no significant difference in IOL power between NO group and OC group (P = 0.064), and the median absolute difference (MedAD) was 0.05D. The IOL power in NO group showed significant differences from OLC group and OL group respectively (P < 0.001), and both MedAD values were 0.18D. Among AL subgroups, MedAD ranged from 0.06D to 0.35D in short eyes. Among ACD subgroups, the above values ranged from 0.06D to 0.23D in shallow ACD subgroup. Among Km subgroups, these values ranged from 0.05D to 0.31D in steep Km subgroup.

Conclusion
The optional biometric parameter CCT has no effect on the calculation results of the Kane formula, whereas the parameter LT has a great influence on the Kane formula results for the IOL power calculation in cataract patients with short AL, shallow ACD and steep Km.
Performance and patients’ satisfaction with the A7+TouchCare insulin patch pump system: A randomized controlled non-inferiority study
Authors: Amadou Coralie , Melki Vincent , Allain Jennifer , Clavel Sylvaine , Gouet Didier , Chaillous Lucy , Catargi Bogdan , Schaeplynck-Belicard Pauline , Petit Catherine , Thivolet Charles , Penfornis Alfred 
Published: August 2023

Background
We assessed the performance and patient satisfaction of a new insulin patch pump, the A7+TouchCare (Medtrum), compared with the Omnipod system.

Methods
This multicenter, randomized, open-label, controlled study enrolled 100 adult patients with type 1 or type 2 diabetes mellitus (A1C ≥ 6.5% and ≤ 9.5%, i.e., 48 to 80 mmol/mol) who were assigned with the Omnipod or with the A7+TouchCare pump for 3 months. The primary study outcome was the glucose management indicator (GMI) calculated with continuous glucose monitoring (CGM).

Results
Premature withdrawals occurs respectively in 2 and 9 participants in the Omnipod and TouchCare groups. In the Per Protocol analysis, the difference in GMI between groups was 0.002% (95% confidence interval -0.251; 0.255). The non-inferiority was demonstrated since the difference between treatments did not overlap the pre-defined non-inferiority margin (0.4%). There was no significant difference in CGM parameters between groups. On average, patients in both groups were satisfied/very satisfied with the insulin pump system. Patients preferred Omnipod as an insulin management system and especially the patch delivery system but preferred the A7+TouchCare personal diabetes manager to control the system.

Conclusions
This study showed that the A7+TouchCare insulin pump was as efficient as the Omnipod pump in terms of performance and satisfaction.

Clinical trail registration
The study was registered in the ClinicalTrials.gov protocol register (NCT04223973).
The Norwegian version of the Copenhagen Psychosocial Questionnaire (COPSOQ III): Initial validation study using a national sample of registered nurses
Authors: Ose Solveig Osborg , Lohmann-Lafrenz Signe , Bernstrøm Vilde Hoff , Berthelsen Hanne , Marchand Gunn Hege 
Published: August 2023

Background
Employers are legally obligated to ensure the safety and health of employees, including the organizational and psychosocial working environment. The Copenhagen Psychosocial Questionnaire (COPSOQ III) covers multiple dimensions of the work environment. COPSOQ III has three parts: a) work environment b) conflicts and offensive behaviours and c) health and welfare. We translated all three parts into Norwegian and evaluated the statistical properties of the 28 work environment dimensions in part a), using a sample of registered nurses.

Methods
The original English version was translated into Norwegian and back translated into English; the two versions were compared, and adjustments made. In total, 86 of 99 items from the translated version were included in a survey to which 8804 registered nurses responded. Item response theory models designed for ordinal manifest variables were used to evaluate construct validity and identify potential redundant items. A standard confirmatory factor analysis was performed to verify the latent dimensionality established in the original version, and a more exploratory factor analysis without restrictions is included to determine dependency between items and to identify separable dimensions.

Results
The measure of sampling adequacy shows that the data are well suited for factor analyses. The latent dimensionality in the original version is confirmed in the Norwegian translated version and the scale reliability is high for all dimensions except ‘Demands for Hiding Emotions’. In this homogenous sample, eight of the 28 dimensions are found not to be separate dimensions as items covering these dimensions loaded onto the same factor. Moreover, little information is provided at the low and high ends of exposure for some dimensions in this sample. Of the 86 items included, 14 are found to be potential candidates for removal to obtain a shorter Norwegian version.

Conclusion
The established Norwegian translation of COPSOQ III can be used in further research about working environment factors and health and wellbeing in Norway. The extended use of the instrument internationally enables comparative studies, which can increase the knowledge and understanding of similarities and differences between labour markets in different countries.
This first validation study shows that the Norwegian version has strong statistical properties like the original, and can be used to assess work environment factors, including relational and emotional risk factors and resources available at the workplace.
Cost-effectiveness of trastuzumab deruxtecan for previously treated HER2-low advanced breast cancer
Authors: Shi Demin , Liang Xueyan , Li Yan , Chen Lingyuan 
Published: August 2023

Objective
The clinical efficacy and safety profile of trastuzumab deruxtecan (T-DXd) have been demonstrated in previously treated patients with human epidermal growth factor receptor 2 (HER2)-low advanced breast cancer (BC). It is, however, necessary to evaluate the value of T-DXd considering both its clinical efficacy and its cost, given that it is high. This study aimed to evaluate the cost-effectiveness of T-DXd versus chemotherapy in patients with previously treated HER2-low advanced BC.

Methods
We used a partitioned survival model that included three mutually exclusive health states. The patients in the model were identified based on their clinical characteristics and outcomes from the DESTINY-Breast04. Probabilistic and one-way sensitivity analyses were performed to evaluate the model’s robustness. Subgroup analyses were also conducted. The measures included costs, life years, quality-adjusted life-years (QALYs), incremental cost-effectiveness ratios (ICERs), incremental net health benefits (INHBs), and incremental net monetary benefits (INMBs).

Results
The ICERs of T-DXd vs. chemotherapy were $83,892/QALY, $82,808/QALY, and $93,358/QALY in all HER2-low advanced BC patients, HER2-positive (HER2+) advanced BC patients and HER2-negative (HER2-) advanced BC patients, respectively. In one-way sensitivity analysis, the cost of T-DXd and hazard ratio (HR) for progression-free survival (PFS) and overall survival (OS) were also identified as key drivers. If the price of T-DXd decreased to $17.00/mg, $17.13/mg, and $14.07/mg, it would be cost-effective at a willingness to pay (WTP) threshold of $50,000/QALY in all HER2-low advanced BC patients, HER2+ advanced BC patients and HER2- advanced BC patients, respectively. At a WTP threshold of $100,000/QALY, the probability of T-DXd being cost-effective was 81.10%, 82.27%, and 73.78% compared to chemotherapy for all HER2-low advanced BC patients, HER2+ advanced BC patients and HER2- advanced BC patients, respectively. Most subgroups of patients with HER2+ disease had a cost-effectiveness probability of > 50%.

Conclusion
From a third-party payer’s perspective in the United States, the findings of the cost-effectiveness analysis revealed that, at the current price, T-DXd is a cost-effective alternative to chemotherapy for patients with prior HER2-low advanced BC, at WTP threshold of $100,000/QALY.
Uniqueness for volume-constraint local energy-minimizing sets in a half-space or a ball
Authors: Xia Chao , Zhang Xuwen 
Published: August 2023

Abstract
In this paper, we prove a Poincaré-type inequality for any set of finite perimeter which is stable with respect to the free energy among volume-preserving perturbation, provided that the Hausdorff dimension of its singular set is at most

n
-
3

{n-3}

. With this inequality, we classify all volume-constraint local energy-minimizing sets in a unit ball, a half-space or a wedge-shaped domain. In particular, we prove that the relative boundary of any energy-minimizing set is smooth.