bluuebunny/crossref_metadata_2025_split huggingface dataset:
Educação jovens e adultos do Proeja no Instituto Federal Catarinense - IFC campus Videira: perfil dos participantes na web
Authors: Rossi Leila Lisiane , Mesquita Marcos Roberto , Rodriguez Ana Carolina Vieira , Camara Lizete Hubler 
Published: September 2023

Com o objetivo de organizar os dados e acompanhar a participação dos integrantes do curso de Educação de Jovens e Adultos do Instituto Federal Catarinense - IFC campus Videira, foi desenvolvida uma ferramenta web que permite a realização de consultas analíticas online - Olaps. Através dessas consultas é possível conhecer o perfil dos participantes, por níveis de detalhamento e de forma analítica. A ferramenta auxilia no processo de tomada de decisão para a adoção de políticas educacionais. Foram geradas também algumas regras de associação por meio de técnicas de mineração de dados, que permitem o descobrimento de padrões nos dados. Consequentemente, poderão ser adotadas estratégias para atrair participantes com base nas consultas da ferramenta desenvolvida e em conformidade com os objetivos do curso.
Pengaruh Dana ZIS dan Inflasi terhadap Tingkat Kemiskinan dengan Mediasi Pertumbuhan Ekonomi
Authors: Amanda Salsa , Anwar Fathoni Muhammad 
Published: September 2023

The decrease in the poverty rate in Indonesia over the past decade has been no more than 1 percent, which is in the range of 0.1 to 0.8 percent, which shows that poverty alleviation in Indonesia has not been too significant. The purpose of this study is to analyze the influence of ZIS funds and inflation on poverty rates in Indonesia by mediating economic growth. The analysis method used is path analysis as an advanced model of multiple linear regression. The results shows that ZIS funds have a significant direct influence on the poverty rate, while inflation and economic growth do not have a significant direct influence on the poverty rate. Then the ZIS fund variables and inflation do not have a significant direct influence on economic growth. In indirect effect testing, economic growth cannot mediate the effect of ZIS funds and inflation on poverty significantly.
Keywords: Poverty; Economic Growth; ZIS; Inflation

Penurunan tingkat kemiskinan di Indonesia selama satu dekade ini tidak lebih dari 1 persen yaitu kisaran 0,1 sampai 0,8 persen yang menunjukkan bahwa pengentasan kemiskinan di Indonesia belum terlalu signifikan. Tujuan dari penelitian ini adalah untuk menganalisis pengaruh ZIS dan inflasi terhadap tingkat kemiskinan di Indonesia dengan mediasi pertumbuhan ekonomi. Metode analisis yang digunakan adalah analisis jalur sebagai model lanjutan dari regresi linear berganda. Hasil penelitian menunjukkan bahwa dana ZIS memiliki pengaruh langsung secara signifikan terhadap tingkat kemiskinan, sedangkan inflasi dan pertumbuhan ekonomi tidak memiliki pengaruh langsung secara signifikan terhadap tingkat kemiskinan. Kemudian variabel dana ZIS dan inflasi tidak memiliki pengaruh langsung secara signifikan terhadap pertumbuhan ekonomi. Pada pengujian pengaruh tidak langsung, pertumbuhan ekonomi tidak dapat memediasi pengaruh dana ZIS dan inflasi terhadap kemiskinan secara signifikan.
Kata kunci: Kemiskinan; Pertumbuhan Ekonomi; ZIS; Inflasi
Racial Differences in Clinical Presentation in Individuals Diagnosed With Frontotemporal Dementia
Authors: Jin Hannah A. , McMillan Corey T. , Yannatos Isabel , Fisher Lauren , Rhodes Emma , Jacoby Sarah F. , Irwin David J. , Massimo Lauren 
Published: September 2023

ImportancePrior research suggests there are racial disparities in the presentation of dementia, but this has not been investigated in the context of frontotemporal dementia (FTD).ObjectiveTo explore racial disparities in dementia severity, functional impairment, and neuropsychiatric symptoms in individuals with a diagnosis of FTD.Design, Setting, and ParticipantsThis exploratory cross-sectional study of National Alzheimer’s Coordinating Center (NACC) data collected between June 2005 to August 2021 evaluated Asian, Black, and White individuals with a diagnosis of FTD (behavioral variant FTD or primary progressive aphasia). Excluded were races with limited data, including American Indian or Alaska Native (n = 4), Native Hawaiian or other Pacific Islander (n = 3), other (n = 13), and unknown (n = 24), and participants with symptom duration more than 4 SDs above the mean.Main Outcomes and MeasuresRacial differences at initial NACC visit were examined on Clinical Dementia Rating Dementia Staging Instrument plus NACC Frontotemporal Lobar Degeneration Behavior &amp;amp; Language Domains (FTLD-CDR), Functional Assessment Scale, and Neuropsychiatric Inventory using regression models. Matching was also performed to address the imbalance between racial groups.ResultsThe final sample comprised 2478 individuals, of which 59 (2.4%) were Asian, 63 (2.5%) were Black, and 2356 (95.1%) were White. The mean (SD) age at initial visit was 65.3 (9.4) years and symptom duration at initial visit was 67.5 (35.6) months. Asian and Black individuals were considerably underrepresented, comprising a small percent of the sample. Black individuals had a higher degree of dementia severity on FTLD-CDR (β = 0.64; SE = 0.24; P = .006) and FTLD-CDR sum of boxes (β = 1.21; SE = 0.57; P = .03) and greater functional impairment (β = 3.83; SE = 1.49; P = .01). There were no differences on FTLD-CDR and Functional Assessment Scale between Asian and White individuals. Black individuals were found to exhibit a higher frequency of delusions, agitation, and depression (delusions: odds ratio [OR], 2.18; 95% CI, 1.15-3.93; P = .01; agitation: OR, 1.73; 95% CI, 1.03-2.93; P = .04; depression: OR, 1.75; 95% CI, 1.05-2.92; P = .03). Asian individuals were found to exhibit a higher frequency of apathy (OR, 1.89; 95% CI, 1.09-3.78; P = .03), nighttime behaviors (OR, 1.72; 95% CI, 1.01-2.91; P = .04), and appetite/eating (OR, 1.99; 95% CI, 1.17-3.47; P = .01) compared to White individuals.Conclusions and RelevanceThis exploratory study suggests there are racial disparities in dementia severity, functional impairment, and neuropsychiatric symptoms. Future work must address racial disparities and their underlying determinants as well as the lack of representation of racially minoritized individuals in nationally representative dementia registries.
Robust and Accessible True Random Number Generator Exploiting the Structural Frustration of Nematic Liquid Crystals
Authors: Lee Jun‐Yong , Lee Jae Hoon , Kim Jae Soon , Yu Jeong‐Seon , Kim Jong‐Hyun 
Published: September 2023

AbstractThe study proposes a highly credible true random number generator based on the structural frustration of nematic liquid crystals, which refers to the appearance of two energetically equivalent structures in a nematic system. Frustration is induced in a simple liquid crystal cell by applying an electric field and observing optical textures under crossed polarizers. A clockwise or counterclockwise spiral image appears on 630 separate circular electrodes under the electric field, and random binary sequences are obtained by assigning a digit of 0 or 1 to each image. These sequences pass the strict statistical randomness tests of the National Institute of Standards and Technology with a pass rate of 0.992 or higher for the ten applicable tests and exhibit excellent uniformity. Furthermore, a simple method is introduced to convert the binary results to random decimal numbers with only a minimal amount of data processing.
Anesthesia‐induced hippocampal‐cortical hyperactivity and tau hyperphosphorylation impair remote memory retrieval in Alzheimer's disease
Authors: Chen Kai , Gupta Riya , Martín‐Ávila Alejandro , Cui Meng , Xie Zhongcong , Yang Guang 
Published: September 2023

AbstractINTRODUCTIONAnesthesia often exacerbates memory recall difficulties in individuals with Alzheimer's disease (AD), but the underlying mechanisms remain unclear.METHODSWe used in vivo Ca2+ imaging, viral‐based circuit tracing, and chemogenetic approaches to investigate anesthesia‐induced remote memory impairment in mouse models of presymptomatic AD.RESULTSOur study identified pyramidal neuron hyperactivity in the anterior cingulate cortex (ACC) as a significant contributor to anesthesia‐induced remote memory impairment. This ACC hyperactivation arises from the disinhibition of local inhibitory circuits and increased excitatory inputs from the hippocampal CA1 region. Inhibiting hyperactivity in the CA1‐ACC circuit improved memory recall after anesthesia. Moreover, anesthesia led to increased tau phosphorylation in the hippocampus, and inhibiting this hyperphosphorylation prevented ACC hyperactivity and subsequent memory impairment.DISCUSSIONHippocampal‐cortical hyperactivity plays a role in anesthesia‐induced remote memory impairment. Targeting tau hyperphosphorylation shows promise as a therapeutic strategy to mitigate anesthesia‐induced neural network dysfunction and retrograde amnesia in AD.
Enhanced electromagnetic interference shielding effectiveness in multiphase nanocomposites based on poly(vinylidene fluoride‐co‐hexafluoropropylene), nano‐Fe2O3, graphene nanoplatelets, and nanodiamonds
Authors: Thanasekaran Gayathri , Ahamed M. Basheer , Deshmukh Kalim , Venkatachalam Subramanian 
Published: September 2023

AbstractIron oxide (Fe2O3) nanoparticles (NPs), graphene nanoplatelets (GNPs), and nanodiamonds (NDs) reinforced poly(vinylidene fluoride‐co‐hexafluoropropylene) (PVDF‐HFP) nanocomposites were synthesized by a solvent casting technique. The structure and morphology of synthesized nanocomposites were studied using Fourier‐transform infrared spectroscopy, X‐ray diffraction, and scanning electron microscopy. The thermal behavior of polymer nanocomposites (PNCs) was studied by the thermogravimetric analysis and the derivative thermogravimetry. The dielectric measurements were carried out within the temperature range from 40 to 150°C and in the frequency range from 50 Hz to 15 MHz. At 50 Hz, 140°C, the highest dielectric constant of 92.46 was noted, for the PVDF‐HFP + 10 wt% Fe2O3 + 6 wt% GNPs + 3 wt% NDs and the highest dielectric loss tangent has been observed to be 24.75 at 50 Hz, 140°C for the PVDF‐HFP + 10 wt% Fe2O3 + 4 wt% GNPs + 2 wt% NDs. The electromagnetic interference shielding effectiveness (EMI SE) was studied in the X‐band and Ku‐band frequency regions (8–18 GHz). High EMI SE values of 31.60 dB and 34 dB were observed for PVDF‐HFP/Fe2O3/GNPs/NDs nanocomposites with 10 wt% Fe2O3 + 8 wt% GNPs + 4 wt% NDs in X‐band and Ku‐band, respectively. These findings suggests PVDF‐HFP/Fe2O3/GNPs/NDs‐based PNCs as an appealing material for EMI shielding applications.
Exploration of 3‐aryl pyrazole‐tethered sulfamoyl carboxamides as carbonic anhydrase inhibitors
Authors: Ommi Ojaswitha , Paoletti Niccolò , Bonardi Alessandro , Gratteri Paola , Bhalerao Harshada Anil , Sau Shashikanta , Nanduri Srinivas , Mohammed Arifuddin , Kalia Nitin Pal , Sonti Rajesh , Supuran Claudiu T. , Yaddanapudi Venkata Madhavi 
Published: September 2023

AbstractHerein, we report the design and synthesis of two series of pyrazole‐tethered sulfamoyl phenyl acetamides and pyrazole‐tethered sulfamoyl phenyl benzamides. The synthesized compounds were investigated for inhibiting two human carbonic anhydrases, human carbonic anhydrases (hCA) I and II, and those of the bacterial pathogen Mycobacterium tuberculosis, mtCA 1–3. The results indicate that, among the synthesized compounds, pyrazoles with 4‐aminobenzene sulfonamide were more selective toward hCA I and II over mtCAs, and compounds with 3‐aminobenzene sulfonamide were selective toward mtCA 1–3 over hCA I, II. Compound 6g showed significant and selective inhibition toward hCA I and II, with Ki values of 0.0366 and 0.0310 µM, respectively. Compound 5g exhibited the best inhibition toward mtCA 2, with a Ki value of 0.0617 µM. Among the benzamides, compound 9b exhibited significant activity toward mtCA 2, with a Ki value of 0.0696 µM. Selectivity of these compounds was further supported by docking studies. When tested for antitubercular activity, many compounds showed moderate to good inhibition against the Mtb H37Rv strain, with minimum inhibitory concentration (MIC) values in the range of 4–128 µg/mL.
Oxidative Stress by the Mitochondrial Monoamine Oxidase B Mediates Calcium Pyrophosphate Crystal–Induced Arthritis
Authors: Venegas Francisca C. , Sánchez‐Rodríguez Ricardo , Luisetto Roberto , Angioni Roberta , Viola Antonella , Canton Marcella 
Published: September 2023

ObjectiveCalcium pyrophosphate (CPP) crystal deposition in the joints is associated with a heterogeneous set of debilitating syndromes characterized by inflammation and pain, for which no effective therapies are currently available. Because we found that the mitochondrial enzyme monoamine oxidase B (MAO‐B) plays a fundamental role in promoting inflammatory pathways, this study aims at assessing the efficacy of two clinical‐grade inhibitors (iMAO‐Bs) in preclinical models of this disease to pave the way for a novel treatment.MethodsWe tested our hypothesis in two murine models of CPP‐induced arthritis, by measuring cytokine and chemokine levels, along with immune cell recruitment. iMAO‐Bs (rasagiline and safinamide) were administered either before or after crystal injection. To elucidate the molecular mechanism, we challenged in vitro primed macrophages with CPP crystals and assessed the impact of iMAO‐Bs in dampening proinflammatory cytokines and in preserving mitochondrial function.ResultsBoth in preventive and therapeutic in vivo protocols, iMAO‐Bs blunted the release of proinflammatory cytokines (interleukin [IL]‐6 and IL1‐β) and chemokines (CXCL10, CXCL1, CCL2 and CCL5) (n > 6 mice/group). Importantly, they also significantly reduced ankle swelling (50.3% vs 17.1%; P < 0.001 and 23.1%; P = 0.005 for rasagiline and safinamide, respectively). Mechanistically, iMAO‐Bs dampened the burst of reactive oxygen species and the mitochondrial dysfunction triggered by CPP crystals in isolated macrophages. Moreover, iMAO‐Bs blunted cytokine secretion and NLRP3 inflammasome activation through inhibition of the NF‐κB and STAT3 pathways.ConclusioniMAO‐Bs dampen inflammation in murine models of crystal‐induced arthropathy, thereby uncovering MAO‐B as a promising target to treat these diseases.
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The anti‐spermatogenic activity of nanoliposomes loaded with Heracleum persicum phenolic compounds in Balb/C mice
Authors: Alami Seyed Amirsajjad , Payrovnaziri Aryan , Seghatoleslami Saeed , Faraji Sara , Bajgiran Fatemeh Rahimzadeh , Poorbagher Mahsa Rastegar Moghaddam , Shafaei Negin , Karimi Ehsan , Oskoueian Ehsan 
Published: September 2023

AbstractThere are various types of bioactivities that have been reported for Heracleum persicum species, such as antioxidant, anti‐inflammatory, and cytotoxicity properties. In the current study, the bio‐accessibility of H. persicum bioactive compounds was improved by purifying its phenolic‐enriched fractions (PEF) and encapsulating them into nanoliposomes to analyze its cytotoxic impacts on mice testicular tissue and their fertility status. Nano liposomal H. persicum PEF (NL‐HPEF) was prepared by ultrasound‐based encapsulation of HPEF and L‐agranular lecithin mixture. The size, morphology, and stability of NL‐HPEF were characterized by dynamic light scattering, field emission scanning electron microscopy, and zeta potential analysis. The 18 white male Balb/c mice (20–25 g) at 3 treatment groups were provided to study the NL‐HPPF cytotoxicity by measuring the mice liver enzyme including aspartate aminotransferase (AST), ALP and alanine aminotransferase (ALT), testis lipid peroxidation, and testicular tissue destruction levels. Moreover, the mice's fertility was evaluated by studying the Adam3, Prm1, Spata19, and Tnp2 gene expression in the testicular tissues. The obtained results manifested that the synthesized NL‐HPEF was stable (193.7 nm) and exhibited a notable cytotoxic impact on the mice's liver (ALT and AST enhancement levels) and testicular tissues. Moreover, their increasing treatment doses impaired the male mice's fertility by decreasing the sperm count, viability, and motility. In addition, fertility suppression was verified by decreasing serum testosterone and downregulating the Adam3, Prm1, Spata19, and Tnp2 gene expression in their testicular tissues. The male mice's fertility was significantly (p < 0.05) suppressed by increasing treatment doses of NL‐HPEF. Hence, the NL‐HPEF could be considered a promising alternative to replace the male chemical contraceptives drugs.
Biological systems — “Symphonies of Life”: Reviving Friedrich Cramer's general resonance theory
Authors: Angeler David G. 
Published: September 2023

AbstractUnderstanding biological systems in terms of scientific materialism has arguably reached a frontier, leaving fundamental questions about their complexity unanswered. In 1998, Friedrich Cramer proposed a general resonance theory as a way forward. His theory builds on the extension of the quantum physical duality of matter and wave to the macroscopic world. According to Cramer’ theory, agents constituting biological systems oscillate, akin to musical soundwaves, at specific eigenfrequencies. Biological system dynamics can be described as “Symphonies of Life” emerging from the resonance (and dissonance) of eigenfrequencies within the interacting collective. His theory has potential for studying biological problems of increasing complexity in a fast‐changing Anthropocene from a new and transdisciplinary angle. Despite data becoming increasingly available for analyses, Cramer's theory remains ignored and therefore untested a quarter century after its publication. This paper discusses how the theory can move to quantitative assessments and application. Cramer's general resonance theory deserves revival.
Isocucurbic Acid Derivatives and Soluble Epoxide Hydroxylase Inhibitors from the Flowers of Chrysanthemum indicum L.
Authors: Trang Bui Thi Thu , Kim Jang Hoon , Luyen Bui Thi Thuy 
Published: September 2023

AbstractSoluble epoxide hydrolase (sEH) inhibitory activity guided fractionation and isolation of two new isocucurbic acid derivatives (1 and 2) and nine known compounds (3–11) from the flowers of Chrysanthemum indicum L. Their structures were elucidated on the basis of spectroscopic data interpretation and comparison with those reported in previous studies. Luteolin (3), acacetin‐7‐O‐β‐D‐glucopyranoside (6), and methyl 3,4‐di‐O‐caffeoylquinate (10) displayed sEH inhibitory activities with IC50 values ranging from 13.7±3.6 to 20.8±0.4 μM. Enzyme kinetic analysis revealed that 3, 6, and 10 were non‐competitive inhibitors with Ki values of 14.8±0.5, 31.2±0.8, and 3.9±0.2 μM, respectively. Additionally, molecular docking studies indicated compound 10 had the ability to form six hydrogen bonds at sEH active site, resulting binding energy as low as −9.58 Kcal/mol.
Psychological screening service for men newly admitted to an Italian prison: Preliminary clinical outcome analysis after 1 year of clinical activity
Authors: Pelizza Lorenzo , Rossi Enrico , Zambelli Ursula , Violante Elisa , Scarci Melania , Mammone Elena , Adriani Adriana , Pupo Simona , Paulillo Giuseppina , Pellegrini Pietro 
Published: September 2023

AbstractBackgroundScreening for mental disorders among prisoners is crucial for early detection and intervention of psychopathology and substance use disorders. In Italy, only a minority of prisons have implemented a structured screening process, and there is not yet a standard approach to this worldwide.AimsFirst, to describe a systematic psychological screening for early identification of mental disorder, including drug use disorders, and suicide risk among men on reception into one Italian prison, designed to inform management and, secondly, to describe mental health outcomes among those prisoners accepted into the in‐reach mental health service as a result of the assessment.MethodsAll prisoners newly received in the Parma Penitentiary Institute at any time in 2020 were screened using the Jail Screening Assessment Tool. Those who screened positive for any mental disorder, including substance use disorders and suicide indicators, were asked to complete the Parma Scale for the treatment evaluation of offenders with psychiatric disorders (Pr‐Scale), a locally developed tool that allows for the measurement of mental state change as well as changes in treatment and management. Scores on this scale soon after reception were compared with scores after 1 year of work with the in‐reach team.ResultsAmong 303 newly admitted male prisoners in 2020, 167 (55%) screened positive for substance use disorder and 30 (10%) for other primary mental disorders. Most of these (n = 151) were offered and accepted care by the mental health in‐reach service. After 1 year, those who had been treated by this service showed significant improvement in all Pr‐Scale clinical variables.ConclusionsOur findings support the extension of a psychological screening into a service for new receptions to Italian prisons. They add evidence for the utility of the Pr‐Scale for detecting those newly admitted prisoners likely to benefit from early mental health interventions provided by in‐reach services and for evidencing resultant change. Future studies are needed to replicate our results in other Italian prisons as a precursor to systems improvement, while other countries might also benefit from using similar evaluation and reevaluation routinely.
Oxy‐ and Chloroarylation Pathways in Gold‐Mediated Cyclization of 2‐Aminoaryl‐3‐arylpropargyl‐benzenesulfonamides
Authors: Díaz‐Salazar Howard , Medina‐Mercado Ignacio , Salvador‐Reyes Román , Barquera‐Lozada José Enrique , Martínez‐Otero Diego , Porcel Susana 
Published: September 2023

AbstractA one‐pot diazotization/gold‐mediated cyclization of 2‐aminoaryl‐3‐arylpropargyl‐benzenesulfonamides is described. After diazotization, Me2SAuCl triggers an oxy‐ and/or chloroarylation of the alkyne moiety, resulting in the formation of 3‐acylindoles and/or Z‐3‐(chloromethylene)indolines. Density Functional Theory (DFT) calculations show the significant energetic preference of both processes over an insertion pathway. Notably, a Z‐3‐(chloromethylene)indoline crystallized with [Cl‐Au‐Cl],− exhibiting Au⋅⋅⋅H−C short contacts.
Barriers and motivators to women’s cancer screening: A qualitative study of a sample of diverse women
Authors: MacKinnon Kelsey M. , Risica Patricia Markham , von Ash Tayla , Scharf Allegra L. , Lamy Eric C. 
Published: September 2023

AbstractIntroductionCancer is an enormous public health challenge in the United States and around the world. Early detection through screening can identify cancer when it is most treatable and can result in greater survival rates; however, racial and ethnic disparities in breast and cervical screening result in late diagnosis and a higher risk of poor outcomes and death for women of color.PurposeThe purpose of this study was to examine barriers that a diverse sample of women in Rhode Island face related to breast and cervical cancer screening, as well as motivators that encourage women to obtain screening services.Design and methodsWomen, most of whom self‐identified as Black or Hispanic, who were aged 40 years and older, were recruited to participate in focus groups via Zoom. The main topics of the discussions included thoughts, attitudes, beliefs, and prior experiences with screening.ResultsForty‐seven women from Rhode Island participated in a total of six focus groups. The following themes emerged: (1) fear, lack of knowledge, cultural beliefs, and the role of women as caretakers are personal barriers; (2) communication challenges, a shortage of primary care providers and negative health experiences are system barriers; and (3) family history of cancer, encouragement from providers, and clinic reminders are motivators that encourage women to get screened.ConclusionsResults suggest that communities must focus on eliminating barriers, promoting motivators, and expanding access to supportive screening services to reduce the number of cases and deaths due to breast and cervical cancer.