bluuebunny/crossref_metadata_2025_split huggingface dataset:
‘Stand up like a Taiwanese!’: PRC coercion and public preferences for resistance
Authors: Chong Ja Ian , Huang David W. F. , Wu Wen-Chin 
Published: March 2023

AbstractTaiwan's opposition to PRC demands such as acceptance of the ‘92 Consensus’ and ‘One Country, Two Systems’ formula since 2016 has invited a series of retaliatory measures from Beijing, designed to coerce Taiwan into compliance. Given the stark asymmetry in economic size, military capability, and diplomatic status, Taiwan provides a case for studying coercive diplomacy that takes the form of threats to punish. Material differences suggest that Taiwan should capitulate, and ‘cheap talk’ theses expect PRC threats to have no discernible effect, while balance of threat arguments expect resolve. In this article, we use the survey data collected in the 2016, 2019, and 2020 rounds of the Taiwan National Security Study to examine how Taiwanese respond to China's intensifying and expanding threats. Our paper identifies four strategies that the public sees as responses to PRC coercion: isolation, bandwagon with China, balance against China by allying with the USA and Japan, and hedge by deepening economic ties with China while aligning with the USA and Japan against China. We show that the popular support for balancing against China rises as PRC coercion grows and Taiwanese citizens increasingly perceive China to be a threat. Our findings imply that citizens in a liberal democracy can develop the will to pushback against pressure from an authoritarian regime despite sharp asymmetries in capabilities and material limitations.
Explaining fluctuations in the Thrift Savings Fund daily balance at U.S. treasury
Authors: Skidmore Mark , Alvayay Torrejón Camila , Pare David 
Published: March 2023

AbstractThis article examines the G-Fund, which is one of the five funds in the federal government employee retirement Thrift Savings Plan. The G-Fund is held as internal debt by the U.S. Department of Treasury. Our examination shows that the fund balance is exclusively composed of 1-day notes that are redeemed/reissued every business day, generating $55 trillion in annual debt reissuance. We also show that the fund balance drops substantially as resources are transferred to the general fund when the government is constrained by a debt ceiling and returns to pre-constraint levels when the ceiling is expanded/suspended.
Effect of a single dose of intravenous ketamine on the wish to hasten death in palliative care: A case report in advanced cancer
Authors: Decazes Esther , Rigal Oliver , Clatot Florian 
Published: March 2023

AbstractObjectivesThe suffering experienced by some patients at the end of their lives can lead to a wish to hasten death (WTHD). It is sometimes an existential suffering, refractory to palliative care even if well conducted, which leads to this desire. Since several years, in psychiatry, the rapid anti-suicidal effects of a single injection of ketamine have been proven. WTHD and suicidal ideation have similarities. The injection of a single dose of ketamine could have an efficiency on the desire to hasten death.MethodsWe report the case of a woman with advanced breast cancer expressing a WTHD, treated by ketamine.ResultsA 78-year-old woman expressed a WTHD (request for euthanasia) because of existential suffering following a loss of autonomy related to cancer. The suicide item was 4 on the Montgomery–Åsberg Depression Rating Scale (MADRS). She had no associated pain or depression. A single dose of intravenous ketamine 1 mg/kg over 40 min plus 1 mg of midazolam was injected. She had no adverse effects. From D1 post-injection to D3, the WTHD disappeared completely with a MADRS suicide item at 0. At D5, the WTHD started to reappear, and at D6, the previous speech was completely back.Significance of the resultsThese results suggest an effect of ketamine on WTHD. This opens up the possibility of treating existential suffering at the end of life. The optimal dosage of this treatment would have to be determined as well as a maintenance of efficacy scheme.
Rapid necrosis: Implications of environmental conditions and plant growth stage on 2,4-D resistance and effect of other auxinic herbicides in Sumatran fleabane (Conyza sumatrensis)
Authors: Angonese Paula Sinigaglia , de Queiroz Andrew Rerison Silva , Angonese Liana Sinigaglia , Machado Filipi Mesquita , Napier Richard , Markus Catarine , Delatorre Carla A. , Merotto Aldo 
Published: March 2023

AbstractResistant plants of Sumatran fleabane with unusual rapid necrosis (RN) symptoms after application of 2,4-D were characterized in previous studies. Field observations indicated variability in the occurrence of the RN caused by 2,4-D, but the causes of the variation are unknown. This study aimed to investigate the effect of environmental conditions, plant growth stage, and simultaneous and sequential herbicide mixtures with other auxin mimics on the occurrence of RN caused by 2,4-D. Application at temperature of 12 C delayed the symptoms and decreased the intensity of the RN but still resulted in plant survival to 2,4-D. The absence of light after herbicide application caused a slight delay in the symptoms, but the production of hydrogen peroxide and the size of the necrosed area were not affected by the light treatments before and after 2,4-D application. Changes in plant photosynthesis through inhibiting photosystem II do not prevent the occurrence of RN symptoms. The auxinic herbicides dicamba, triclopyr, and halauxifen-methyl do not cause RN symptoms and are effective at controlling the resistant biotype when applied without 2,4-D, but the effectiveness of these herbicides was reduced when sprayed on the resistant biotype either together, 4 h, or 24 h after 2,4-D. The RN phenotype does not occur for dicamba and triclopyr, even in advanced plant growth stages and high doses on the resistant biotype. The herbicides dicamba and triclopyr effectively controlled resistant plants, especially when sprayed at the initial growth stages. The results of this study identify environmental effects, plant development effects, and herbicide interactions that interfere with the occurrence of RN symptoms caused by 2,4-D in Sumatran fleabane. These data provide insights about the mechanisms behind the RN symptoms caused by 2,4-D and are important for identifying the causes of variability of the herbicide symptomology and performance under experimental and field conditions.
Community‐Engaged Assessment of Soil Lead Contamination in Atlanta Urban Growing Spaces
Authors: Peters Samuel J. W. , Warner Sydney M. , Saikawa Eri , Ryan P. Barry , Panuwet Parinya , Barr Dana B. , D'Souza Priya E. , Frank Gil , Hernandez Rosario , Alvarado Taranji , Hines Arthur , Theal Chris 
Published: March 2023

AbstractUrban agriculture is emerging as a method to improve food security and public health in cities across the United States. However, an increased risk of exposure to heavy metals and metalloids (HMM) exists through interaction with contaminated soil. Community‐engaged research (CEnR) is one method that can promote the inclusion of all partners when studying exposures such as HMM in soil. Researchers and community gardeners co‐designed this study to measure the concentrations of lead (Pb), using X‐Ray Fluorescence (XRF) verified with Inductively Coupled Plasma‐Mass Spectrometry (ICP‐MS) in soils from 19 urban agricultural and residential sites in the Westside of Atlanta and three rural sites in Georgia. Seventeen other HMM were measured but not included in this study, because they did not pose risks to the community comparable to elevated Pb levels. Pb concentrations were compared to the Environmental Protection Agency (EPA)'s regional screening levels (RSLs) for residential soil and the University of Georgia (UGA) extension service's low‐risk levels (LRLs) for agriculture. Soils from the majority of sites had levels below EPA RSLs for Pb, yet above the UGA LRL. However, soil Pb concentrations were three times higher than the EPA RSL on some sites that contained metal refining waste or slag. Our findings led to direct action by local and federal government agencies to initiate the cleanup of slag residue. Studies involving exposures to communities should engage those affected throughout the process for maximum impact.
Properties of Flapping Current Sheet of the Martian Magnetotail
Authors: Zhang Chi , Rong Zhaojin , Zhang Lulu , Gao Jiawei , Shi Zhen , Klinger Lucy , Shen Chao , Wei Yong 
Published: March 2023

AbstractKnowing the properties of the Martian magnetotail flapping waves is critical to understand the dynamics of the Martian induced magnetosphere. Based on the measurements by Mars Atmosphere and Volatile EvolutioN and a newly developed method, we provide the first quantitative study of Martian magnetotail flapping waves in comparison with Earth's magnetotail flapping waves. We found that the period of Martian magnetotail flapping waves ranges from ∼50 to ∼250 s. The estimated average wave amplitude is ∼380 km, and the wavelength is ∼1,100 km. The estimated propagation speed ranges from ∼3 to ∼30 km/s, which is about a third of that of Earth's magnetotail flapping waves, and the speed declines with the increase of the current sheet thickness. Intriguingly, we found that the flapping waves with shorter periods, or lower wavelengths, can propagate faster, showing similar dispersive signatures as that found in the Earth's magnetotail. Our results demonstrate that the fluctuated field energy carried by flapping waves within unit time along unit magnetotail length is one order higher than that of Earth's flapping waves, as normalized by the magnetic energy of planetary magnetotail. Thus, in comparison with Earth's magnetotail, the flapping waves of Martian induced magnetotail would play a more important role in affecting the magnetotail dynamics.
Super-reflector enabled by non-interleaved spin-momentum-multiplexed metasurface
Authors: Xu He-Xiu , Hu Guangwei , Kong Xianghong , Shao Yanzhang , Genevet Patrice , Qiu Cheng-Wei 
Published: March 2023

AbstractElectromagnetic wave multiplexing, especially for that occurring at different incidences (spatial-frequency multiplexing), is pivotal for ultrathin multifunctional interfaces and high-capacity information processing and communication. It is yet extremely challenging based on passive and compact wave elements, since the wave excitation and scattering channels are exclusively coupled through gradient phases and hence momentum matching condition at the interface. Here, we propose a spin-momentum multiplexed paradigm called a super-reflector enabling on-demand control of both retroreflections and anomalous reflections using a non-interleaved single-celled metasurface. By multiplexing four channels connecting two spin states excited onto each input of three spatial frequencies, a total of twelve channels are engineered, among which three are retroreflected channels and the residual are anomalous reflection ones. Our compound multiplexed super-reflector allows five degrees of freedom in circular polarization Jones' matrix, approaching the intrinsic upper limit of such planar metasurface. The concept has been experimentally verified by a proof-of-concept super-reflector at microwave frequency, showcasing twelve reflected beams and a high efficiency exceeding 90.6% defined as the ratio of reflected power to incidence for each channel beam. Our strategy opens a new avenue for angle multiplexing and angle-resolved metadevices toward the capacity limit of 2D planar Jones’ matrix.
Imatinib blocks tyrosine phosphorylation of Smad4 and restores TGF-β growth-suppressive signaling in BCR-ABL1-positive leukemia
Authors: Wang Lijing , Gu Shuchen , Chen Fenfang , Yu Yi , Cao Jin , Li Xinran , Gao Chun , Chen Yanzhen , Yuan Shuchong , Liu Xia , Qin Jun , Zhao Bin , Xu Pinglong , Liang Tingbo , Tong Hongyan , Lin Xia , Feng Xin-Hua 
Published: March 2023

AbstractLoss of TGF-β-mediated growth suppression is a major contributor to the development of cancers, best exemplified by loss-of-function mutations in genes encoding components of the TGF-β signaling pathway in colorectal and pancreatic cancers. Alternatively, gain-of-function oncogene mutations can also disrupt antiproliferative TGF-β signaling. However, the molecular mechanisms underlying oncogene-induced modulation of TGF-β signaling have not been extensively investigated. Here, we show that the oncogenic BCR-ABL1 of chronic myelogenous leukemia (CML) and the cellular ABL1 tyrosine kinases phosphorylate and inactivate Smad4 to block antiproliferative TGF-β signaling. Mechanistically, phosphorylation of Smad4 at Tyr195, Tyr301, and Tyr322 in the linker region interferes with its binding to the transcription co-activator p300/CBP, thereby blocking the ability of Smad4 to activate the expression of cyclin-dependent kinase (CDK) inhibitors and induce cell cycle arrest. In contrast, the inhibition of BCR-ABL1 kinase with Imatinib prevented Smad4 tyrosine phosphorylation and re-sensitized CML cells to TGF-β-induced antiproliferative and pro-apoptotic responses. Furthermore, expression of phosphorylation-site-mutated Y195F/Y301F/Y322F mutant of Smad4 in Smad4-null CML cells enhanced antiproliferative responses to TGF-β, whereas the phosphorylation-mimicking Y195E/Y301E/Y322E mutant interfered with TGF-β signaling and enhanced the in vivo growth of CML cells. These findings demonstrate the direct role of BCR-ABL1 tyrosine kinase in suppressing TGF-β signaling in CML and explain how Imatinib-targeted therapy restored beneficial TGF-β anti-growth responses.
Occlusal records in the production of mounted study casts for tooth wear planning and management
Authors: Cowan Callum 
Published: March 2023

AbstractThis article forms part of a series looking at management of patients with tooth wear. Articulated study casts can be essential in assisting the clinician to plan and communicate proposed treatment to the dental technician and patient. Their production is often seen as straightforward, but a lack of attention to detail can quickly lead to articulated casts that do not replicate the patient clinical presentation. This in turn will lead to inaccurate planning and potentially a suboptimal treatment outcome. This article discusses a collection of the clinical records needed to produce accurate articulated study casts, which can be utilised for tooth wear planning. It also aims to present the evidence base for the recommendations outlined.
Gastrointestinal conditions related to tooth wear
Authors: Howard John P. , Howard Laura J. , Geraghty Joe , Leven A. Johanna , Ashley Martin 
Published: March 2023

AbstractGastro-oesophageal reflux disease (GORD) is a relatively common condition that occurs in adults and less commonly in children. It develops when the reflux of stomach contents into the oesophagus causes troublesome symptoms and/or complications. Signs and symptoms include heartburn, retrosternal discomfort, epigastric pain and hoarseness, dental erosion, chronic cough, burning mouth syndrome, halitosis and laryngitis. A proportion of patients will, however, have silent reflux. Strongly associated risk factors include family history, age, hiatus hernia, obesity and neurological conditions, such as cerebral palsy. There are different treatment options which may be considered for GORD, consisting of conservative, medical and surgical therapy. Dentists should be aware of the symptoms of GORD and dental signs of intrinsic erosion indicative of possible GORD so that they can question patients about this and, if appropriate, initiate a referral to a general medical practitioner.
The rhythmic coupling of Egr-1 and Cidea regulates age-related metabolic dysfunction in the liver of male mice
Authors: Wu Jing , Bu Dandan , Wang Haiquan , Shen Di , Chong Danyang , Zhang Tongyu , Tao Weiwei , Zhao Mengfei , Zhao Yue , Fang Lei , Li Peng , Xue Bin , Li Chao-Jun 
Published: March 2023

AbstractThe liver lipid metabolism of older individuals canbecome impaired and the circadian rhythm of genes involved in lipid metabolism is also disturbed. Although the link between metabolism and circadian rhythms is already recognized, how these processes are decoupled in liver during aging is still largely unknown. Here, we show that the circadian rhythm for the transcription factor Egr-1 expression is shifted forward with age in male mice. Egr-1 deletion accelerates liver age-related metabolic dysfunction, which associates with increased triglyceride accumulation, disruption of the opposite rhythmic coupling of Egr-1 and Cidea (Cell Death Inducing DFFA Like Effector A) at the transcriptional level and large lipid droplet formation. Importantly, adjustment of the central clock with light via a 4-hour forward shift in 6-month-old mice, leads to recovery the rhythm shift of Egr-1 during aging and largely ameliorated liver metabolic dysfunction. All our collected data suggest that liver Egr-1 might integrate the central and peripheral rhythms and regulate metabolic homeostasis in the liver.
Marine ecosystem shifts with deglacial sea-ice loss inferred from ancient DNA shotgun sequencing
Authors: Zimmermann Heike H. , Stoof-Leichsenring Kathleen R. , Dinkel Viktor , Harms Lars , Schulte Luise , Hütt Marc-Thorsten , Nürnberg Dirk , Tiedemann Ralf , Herzschuh Ulrike 
Published: March 2023

AbstractSea ice is a key factor for the functioning and services provided by polar marine ecosystems. However, ecosystem responses to sea-ice loss are largely unknown because time-series data are lacking. Here, we use shotgun metagenomics of marine sedimentary ancient DNA off Kamchatka (Western Bering Sea) covering the last ~20,000 years. We traced shifts from a sea ice-adapted late-glacial ecosystem, characterized by diatoms, copepods, and codfish to an ice-free Holocene characterized by cyanobacteria, salmon, and herring. By providing information about marine ecosystem dynamics across a broad taxonomic spectrum, our data show that ancient DNA will be an important new tool in identifying long-term ecosystem responses to climate transitions for improvements of ocean and cryosphere risk assessments. We conclude that continuing sea-ice decline on the northern Bering Sea shelf might impact on carbon export and disrupt benthic food supply and could allow for a northward expansion of salmon and Pacific herring.
The critical role of ultra-low-energy vibrations in the relaxation dynamics of molecular qubits
Authors: Garlatti E. , Albino A. , Chicco S. , Nguyen V. H. A. , Santanni F. , Paolasini L. , Mazzoli C. , Caciuffo R. , Totti F. , Santini P. , Sessoli R. , Lunghi A. , Carretta S. 
Published: March 2023

AbstractImproving the performance of molecular qubits is a fundamental milestone towards unleashing the power of molecular magnetism in the second quantum revolution. Taming spin relaxation and decoherence due to vibrations is crucial to reach this milestone, but this is hindered by our lack of understanding on the nature of vibrations and their coupling to spins. Here we propose a synergistic approach to study a prototypical molecular qubit. It combines inelastic X-ray scattering to measure phonon dispersions along the main symmetry directions of the crystal and spin dynamics simulations based on DFT. We show that the canonical Debye picture of lattice dynamics breaks down and that intra-molecular vibrations with very-low energies of 1-2 meV are largely responsible for spin relaxation up to ambient temperature. We identify the origin of these modes, thus providing a rationale for improving spin coherence. The power and flexibility of our approach open new avenues for the investigation of magnetic molecules with the potential of removing roadblocks toward their use in quantum devices.
Curvature induces active velocity waves in rotating spherical tissues
Authors: Brandstätter Tom , Brückner David B. , Han Yu Long , Alert Ricard , Guo Ming , Broedersz Chase P. 
Published: March 2023

AbstractThe multicellular organization of diverse systems, including embryos, intestines, and tumors relies on coordinated cell migration in curved environments. In these settings, cells establish supracellular patterns of motion, including collective rotation and invasion. While such collective modes have been studied extensively in flat systems, the consequences of geometrical and topological constraints on collective migration in curved systems are largely unknown. Here, we discover a collective mode of cell migration in rotating spherical tissues manifesting as a propagating single-wavelength velocity wave. This wave is accompanied by an apparently incompressible supracellular flow pattern featuring topological defects as dictated by the spherical topology. Using a minimal active particle model, we reveal that this collective mode arises from the effect of curvature on the active flocking behavior of a cell layer confined to a spherical surface. Our results thus identify curvature-induced velocity waves as a mode of collective cell migration, impacting the dynamical organization of 3D curved tissues.
Field-linear anomalous Hall effect and Berry curvature induced by spin chirality in the kagome antiferromagnet Mn3Sn
Authors: Li Xiaokang , Koo Jahyun , Zhu Zengwei , Behnia Kamran , Yan Binghai 
Published: March 2023

AbstractDuring the past two decades, it has been established that a non-trivial electron wave-function topology generates an anomalous Hall effect (AHE), which shows itself as a Hall conductivity non-linear in magnetic field. Here, we report on an unprecedented case of field-linear AHE. In Mn3Sn, a kagome magnet, the out-of-plane Hall response, which shows an abrupt jump, was discovered to be a case of AHE. We find now that the in-plane Hall response, which is perfectly linear in magnetic field, is set by the Berry curvature of the wavefunction. The amplitude of the Hall response and its concomitant Nernst signal exceed by far what is expected in the semiclassical picture. We argue that magnetic field induces out-of-plane spin canting and thereafter gives rise to nontrivial spin chirality on the kagome lattice. In band structure, we find that the spin chirality modifies the topology by gapping out Weyl nodal lines unknown before, accounting for the AHE observed. Our work reveals intriguing unification of real-space Berry phase from spin chirality and momentum-space Berry curvature in a kagome material.
Many-body bound states and induced interactions of charged impurities in a bosonic bath
Authors: Astrakharchik Grigory E. , Ardila Luis A. Peña , Jachymski Krzysztof , Negretti Antonio 
Published: March 2023

AbstractInduced interactions and bound states of charge carriers immersed in a quantum medium are crucial for the investigation of quantum transport. Ultracold atom-ion systems can provide a convenient platform for studying this problem. Here, we investigate the static properties of one and two ionic impurities in a bosonic bath using quantum Monte Carlo methods. We identify three bipolaronic regimes depending on the strength of the atom-ion potential and the number of its two-body bound states: a perturbative regime resembling the situation of a pair of neutral impurities, a non-perturbative regime that loses the quasi-particle character of the former, and a many-body bound state regime that can arise only in the presence of a bound state in the two-body potential. We further reveal strong bath-induced interactions between the two ionic polarons. Our findings show that numerical simulations are indispensable for describing highly correlated impurity models.