bluuebunny/crossref_metadata_2025_split huggingface dataset:
The nitro to amine reduction: from millions of tons to single molecule studies
Authors: Scaiano Juan C. , Wang Bowen , Bourgonje Connor R. , Yaghmaei Mahzad 
Published: April 2023

Abstract
Palladium nanostructures are interesting heterogeneous catalysts because of their high catalytic activity in a vast range of highly relevant reactions such as cross couplings, dehalogenations, and nitro-to-amine reductions. In the latter case, the catalyst Pd@GW (palladium on glass wool) shows exceptional performance and durability in reducing nitrobenzene to aniline under ambient conditions in aqueous solutions. To enhance our understanding, we use a combination of optical and electron microscopy, in-flow single molecule fluorescence, and bench chemistry combined with a fluorogenic system to develop an intimate understanding of Pd@GW in nitro-to-amine reductions. We fully characterize our catalyst in situ using advanced microscopy techniques, providing deep insights into its catalytic performance. We also explore Pd cluster migration on the surface of the support under flow conditions, providing insights into the mechanism of catalysis. We show that even under flow, Pd migration from anchoring sites seems to be minimal over 4 h, with the catalyst stability assisted by APTES anchoring.
Fluorosumanenes as building blocks for organic crystalline dielectrics
Authors: Yakiyama Yumi , Li Minghong , Sakurai Hidehiro 
Published: April 2023

Abstract
Organic crystalline dielectric materials are attractive target in the field of materials chemistry. In their designing strategy, the molecular motion induced by the external dielectric field is required to maximize the polarization effect in the materials to realize a large dielectric constant. Especially, the molecular motion of curved-π aromatics such as C60 and their supramolecular complexes are the known to show characteristic smoothness in the solid state. In this context, we focused on the in-plane motion of the one of the representative buckybowl, sumanene (Sum) in its curve-to-curve-contacted columnar structure as the new platform of the motion for the emergence of dielectric response. The newly designed and synthesized fluorinated sumanene, 1,1-difluorosumanene (F2-Sum), which possesses two fluorine atoms on the same benzylic carbon of pristine sumanene showed a large dipole moment along the in-plane direction. Thermal analyses, variable temperature X-ray diffraction and IR measurements indicated the presence of in-plane motion of F2-Sum although no clear phase transition was involved. This thermal property of F2-Sum realized an anisotropic dielectric response with a Debye-type dielectric relaxation in the single crystalline state. Further trials to form the solid solution of Sum and F2-Sum in various mixing ratio realized the tuning of the dielectric property.
Special Olympics als Wegbereiter einer inklusiven Gesellschaft? Eine ableismkritische Analyse
Authors: Oldörp Felix , Mihajlovic Christopher , Giese Martin 
Published: April 2023

ZusammenfassungSpecial Olympics (SO) bietet weltweit eine Vielzahl sportlicher Angebote für Menschen mit geistiger Behinderung an. Zahlreiche positive Errungenschaften im Kontext sportlicher Teilhabe durch SO sind durch Studien belegt und anerkannt. Gleichzeitig fehlt es bis dato an kritischen Analysen, die den Beitrag bzw. den Selbstanspruch von SO zur Entwicklung einer inklusiven Gesellschaft hinterfragen. Der Beitrag verfolgt das Ziel, dieses Forschungsdesiderat vor dem Hintergrund ableismkritischer Überlegungen zu diskutieren. Mithilfe einer Dokumentenanalyse werden dazu offizielle Dokumente von Special Olympics Deutschland (SOD) untersucht und Fähigkeitskonstruktionen innerhalb der SOD-Richtlinien analysiert. Die Kategorienbildung erfolgt anhand einer inhaltlich strukturierenden qualitativen Inhaltsanalyse mit deduktiv-induktiver Kategorienbildung mit den vier Hauptkategorien Startberechtigung, Klassifizierungssystem, Prinzip des Aufstiegs und Unified Sports®. Die Ergebnisse zeigen, dass sich v. a. im Kernelement von Special Olympics – dem Sportkonzept – Schlüsselmerkmale ableistischer Ordnungen finden lassen. Über das SO-Konzept wird körperliche Leistungsfähigkeit camoufliert und als entscheidendes Merkmal für gelingende Inklusion definiert. Weitere Forschung v. a. aus Sicht von Menschen mit Behinderung ist nötig, um das inklusive Potential von Special Olympics zu optimieren.
Measurement of Underwater Sound Absorption Coefficient at Variable Hydrostatic Pressures Using an Improved Transfer Function Method
Authors: Fu Yifeng 
Published: April 2023

Abstract
Water-filled impedance tubes are widely used to measure the acoustic properties of underwater sound absorption materials. Traditional transfer function has been applied for sound absorption measurement in air. Because this method needs to switch between two microphones during the test, it is not suitable for a water-filled impedance tube, especially at high hydrostatic pressure. The mounting of the hydrophone is also a challenging problem for water-filled impedance at high hydrostatic pressure. In this study, an improved transfer function method is investigated and a new mounting structure is designed for high hydrostatic pressure. Measurements of the sound absorption coefficient of the polydimethylsiloxane material and a water/air interface are used to verify the improved transfer function method, and an underwater sound absorption material is tested under different hydrostatic pressures. Results show that the developed water-filled impedance has a stable and repeatable performance at the working frequency range from 1,500 to 7,000 Hz, and the testing pressure can increase up to 1.5 MPa with suitable reliability. This can significantly improve the measurement efficiency of the underwater acoustic properties of materials and structure at high hydrostatic pressure.
Auxin‐dependent regulation of cell division rates governs root thermomorphogenesis
Authors: Ai Haiyue , Bellstaedt Julia , Bartusch Kai Steffen , Eschen‐Lippold Lennart , Babben Steve , Balcke Gerd Ulrich , Tissier Alain , Hause Bettina , Andersen Tonni Grube , Delker Carolin , Quint Marcel 
Published: April 2023

AbstractRoots are highly plastic organs enabling plants to adapt to a changing below‐ground environment. In addition to abiotic factors like nutrients or mechanical resistance, plant roots also respond to temperature variation. Below the heat stress threshold, Arabidopsis thaliana seedlings react to elevated temperature by promoting primary root growth, possibly to reach deeper soil regions with potentially better water saturation. While above‐ground thermomorphogenesis is enabled by thermo‐sensitive cell elongation, it was unknown how temperature modulates root growth. We here show that roots are able to sense and respond to elevated temperature independently of shoot‐derived signals. This response is mediated by a yet unknown root thermosensor that employs auxin as a messenger to relay temperature signals to the cell cycle. Growth promotion is achieved primarily by increasing cell division rates in the root apical meristem, depending on de novo local auxin biosynthesis and temperature‐sensitive organization of the polar auxin transport system. Hence, the primary cellular target of elevated ambient temperature differs fundamentally between root and shoot tissues, while the messenger auxin remains the same.
Dosage sensitivity to Pumilio1 variants in the mouse brain reflects distinct molecular mechanisms
Authors: Botta Salvatore , de Prisco Nicola , Chemiakine Alexei , Brandt Vicky , Cabaj Maximilian , Patel Purvi , Doron‐Mandel Ella , Treadway Colton J , Jovanovic Marko , Brown Nicholas G , Soni Rajesh K , Gennarino Vincenzo A 
Published: April 2023

AbstractDifferent mutations in the RNA‐binding protein Pumilio1 (PUM1) cause divergent phenotypes whose severity tracks with dosage: a mutation that reduces PUM1 levels by 25% causes late‐onset ataxia, whereas haploinsufficiency causes developmental delay and seizures. Yet PUM1 targets are derepressed to equal degrees in both cases, and the more severe mutation does not hinder PUM1's RNA‐binding ability. We therefore considered the possibility that the severe mutation might disrupt PUM1 interactions, and identified PUM1 interactors in the murine brain. We find that mild PUM1 loss derepresses PUM1‐specific targets, but the severe mutation disrupts interactions with several RNA‐binding proteins and the regulation of their targets. In patient‐derived cell lines, restoring PUM1 levels restores these interactors and their targets to normal levels. Our results demonstrate that dosage sensitivity does not always signify a linear relationship with protein abundance but can involve distinct mechanisms. We propose that to understand the functions of RNA‐binding proteins in a physiological context will require studying their interactions as well as their targets.
Hypoxia‐inducible factor 1A inhibition overcomes castration resistance of prostate tumors
Authors: Terzic Julie , Abu el Maaty Mohamed A , Lutzing Régis , Vincent Alexandre , El Bizri Rana , Jung Matthieu , Keime Céline , Metzger Daniel 
Published: April 2023

AbstractAndrogen deprivation therapy (ADT) is a cornerstone of prostate cancer (PCa) management. Although tumors initially regress, many progress to a hormone‐independent state termed castration‐resistant PCa (CRPC), for which treatment options are limited. We here report that the major luminal cell population in tumors of Pten(i)pe−/− mice, generated by luminal epithelial cell‐specific deletion of the tumor suppressor PTEN after puberty, is castration‐resistant and that the expression of inflammation and stemness markers is enhanced in persistent luminal cells. In addition, hypoxia‐inducible factor 1 (HIF1) signaling, which we have previously demonstrated to be induced in luminal cells of Pten(i)pe−/− mice and to promote malignant progression, is further activated. Importantly, we show that genetic and pharmacological inhibition of HIF1A sensitizes Pten‐deficient prostatic tumors to castration and provides durable therapeutic responses. Furthermore, HIF1A inhibition induces apoptotic signaling in human CRPC cell lines. Therefore, our data demonstrate that HIF1A in prostatic tumor cells is a critical factor that enables their survival after ADT, and identify it as a target for CRPC management.
The Comparison of Sentiment Analysis of Moon Knight Movie Reviews between Multinomial Naive Bayes and Support Vector Machine
Authors: Ajhari Abdul Azzam 
Published: April 2023

Online movie streaming platforms have changed the current pattern of watching movies. Besides providing convenience in watching anywhere and anytime, this service is provided at a lower cost to moviegoers. The increase in moviegoers on online streaming platforms has resulted in easy-to-find reviews. This review can determine whether they decide to watch the film or not. The moviegoers' reviews can be easily and quickly found for analysis using sentiment analysis to find a film's worthiness. This study used sentiment analysis in classifying Twitter data predictions using the Multinomial Naive Bayes (MNB) and Support Vector Machine (SVM). In the sentiment analysis of labeling with positive and negative categories, a distilled version of BERT (DistilBERT) was used in this study. With a little human assistance in preprocessing, the model worked objectively with an overall accuracy performance on the confusion matrix of 64.50% for the Multinomial Naive Bayes model and 64.12% for the Support Vector Machine model. Performance evaluation was also carried out by calculating the cross-validation accuracy, which resulted in an accuracy of 72.38% for the MNB. Meanwhile, the SVM model obtained an accuracy of 70.19%.
Problematizing Contemporary Islamic Discourse: A Conceptual Modeling of New Heroes in Indonesian Islamic Biographical Films
Authors: Nurmansyah Mochamad Andhy 
Published: April 2023

PurposeThis study problematizes the interconnectedness between religion and media once again within the context of Indonesian biopics. This paper looks at the pattern of transformation of two Islamic elite-authoritative figures into Islamic-popular heroes that are thematically intertwined with Islamic discourse in Indonesia’s reform era. MethodThe research in this article combines several theoretical concepts by examining the relationship between text and context. The social semiotic paradigm of Kress becomes the main theory for disecting the text, while the concept of cultural commodities from Fiske and discourse formation from Foucault become the frame of reference for viewing the relationship between text and context. Results/findingsThe binary modes in those two biopics are not identical, according to this article, but both have transformed the stable concept of historical figures into more complex ones that generate polysemic ideas from an ideological standpoint. This article also explains how the process of meaning formation in the film's two Islamic figures are affected by three entities forming a three-party dialectic model. ConclusionIn the case of two biopics, Sang Pencerah (2010) and Sang Kiai (2013), this article confirms a dynamic model of conceptual design that connects texts and context. It demonstrates the existence of some variables that contribute to the polarization of contemporary Islam discourses in Indonesia.
Achieving Elimination of Perinatal HIV in the United States
Authors: Lampe Margaret A. , Nesheim Steven R. , Oladapo Keydra L. , Ewing Alexander C. , Wiener Jeffrey , Kourtis Athena P. 
Published: April 2023

Abstract
In 2012, the Centers for Disease Control and Prevention published a Framework for Elimination of Perinatal Transmission of HIV in the United States in Pediatrics, setting the goals of an incidence of &lt;1 case of perinatal HIV per 100 000 live births, and a perinatal transmission rate of &lt;1%. We used National HIV Surveillance System data to monitor the numbers of perinatally acquired HIV cases among US-born persons and perinatal HIV diagnosis rates per 100 000 live births to approximate incidence. Perinatal HIV transmission rates from 2010 to 2019 were calculated by using estimates of live births to women with an HIV diagnosis from the National Inpatient Sample, Healthcare Cost and Utilization Project. The annual estimated number of live births to women with diagnosed HIV decreased from 4587 in 2010 to 3525 in 2019, and the number of US-born infants with perinatally acquired HIV decreased from 74 in 2010 to 32 in 2019. Annual perinatal HIV diagnosis rates declined from 1.9 to 0.9 per 100 000 live births, and perinatal HIV transmission rates declined from 1.6% to 0.9%. Racial and ethnic disparities in HIV diagnosis rates persisted but declined substantially over the 10-year period. Both diagnosis and transmission rate elimination goals were first achieved in 2019. To maintain the elimination of perinatal HIV, and to eliminate racial disparities, the continued coordinated effort of health care and public health is required. The approach to perinatal HIV elimination is a public health model that can be replicated or expanded to areas beyond HIV.
PENDAMPINGAN PEMBELAJARAN DAN PEMBERIAN MOTIVASI DALAM MENINGKATKAN MINAT BELAJAR BAGI ANAK-ANAK DI PKBM
Authors: Rahmawati Nurina Kurniasari , Maruf Abdul Hakim , Ahmad Andy , Nurimani Nurimani 
Published: April 2023

Tujuan pengabdian ini adalah untuk membantu para siswa paket di PKBM dalam pembelajaran yang lebih menarik dan menyenangkan sehingga bisa meningkatkan minat belajar siswa untuk terus mendalami pembelajaran seperti matematika, IPA, ekonomi dan sosial. Selain itu pengabdian ini memberikan motivasi kepada siswa terkait masa depan yang akan mereka hadapi setelah lulus nanti. Kurangnya pengetahuan para siswa tentang rencana kedepan membuat banyak siswa PKBM yang justru menjadi pengangguran, hal tersebut karena kurangnya pengetahuan tentang persiapan memasuki dunia kerja serta jika ingin kuliah kurangnya pengetahuan tentang jurusan yang akan diambil dan bagaimana memilih perguruan tinggi yang baik dan benar. Pendampingan pembelajaran ini diharapkan dapat meningkatnya minat belajar dan motivasi para siswa di PKBM Negeri 17 Wilayah Tanjung Priok, dengan jumlah peserta sebanyak 30 mahasiswa yang berasal dari paket B dan C. Metode yang digunakan dalam pengabdian ini adalah persiapan, sosialisasi, dan pelaksanaan kegiatan. Setelah kegiatan dilaksanakan dilakukan analisis dan evaluasi, terlihat bahwa anak- anak mengalami peningkatan dalam pemahaman nya terkait matematika, IPA, matematika dan sosial, motivasi mereka meningkat untuk bisa memperbaiki masa depan mereka dengan melanjutkan ke perguruan tinggi. Kegiatan ini mendapatkan respon yang baik dari para siswa PKBM dan diharapkan bisa terus berlanjut untuk membimbing anak- anak dalam belajar matematika.Kata Kunci: konsep dasar matematika, pengabdian masyarakat, pembelajaran menarik.
PELATIHAN PENULISAN ARTIKEL ILMIAH UNTUK MENINGKATKAN PROFESIONALISME MAHASISWA DALAM MENYUSUN ARTIKEL ILMIAH DAN PUBLIKASI DI JURNAL NASIONAL TERAKREDITASI SINTA
Authors: Karomah Binti , Rukmana Rizal Maarif 
Published: April 2023

Tujuan dari kegiatan ini adalah memberikan edukasi kepada mahasiswa tentang artikel ilmiah dan teknik menyusun artikel ilmiah, jurnal nasional dan jurnal nasional terakreditasi, memberikan tips dan trik dalam menembus publikasi jurnal nasional terakreditasi SINTA, meningkatkan kemampuan mahasiswa dalam menyusun dan mempublikasikan karya tulis ilmiah di jurnal nasional terakreditasi. Metode yang digunakan adalah metode ceramah, dimana materi yang disampaikan adalah penjelasan tentang karya ilmiah, teknik penulisan karya ilmiah, jurnal ilmiah dan publikasi pada jurnal nasional terakreditasi SINTA, diskusi, dimana peserta diberi kesempatan untuk berdiskusi tentang materi yang disampaikan, tugas menyusun karya tulis ilmiah dengan dilakukan pendampingan khusus, monitoring dan evaluasi dari kegiatan tersebut yang dilakukan secara berkala. Hasil yang diperoleh dari kegiatan ini adalah meningkatnya pengetahuan mahasiswa dalam hal artikel ilmiah, sistematika penulisan artikel ilmiah, dan prosedur publikasi ilmiah pada jurnal nasional terakreditasi SINTA yang dibuktikan dari hasil nilai postest, meningkatnya kualitas artikel ilmiah yang dihasilkan mahasiswa, dimana setelah diadakan program pengabdian ini mahasiswa mampu menulis artikel ilmiah dengan bimbingan dari tim, meningkatnya kuantitas artikel ilmiah yang dihasilkan mahasiswa, dimana sudah ada 20 artikel mahasiswa yang sudah masuk ke tim pengabdi untuk direview dan selanjutnya diberi rekomendasi untuk dipublikasikan ke salah satu artikel ilmiah. Simpulan utama dari kegiatan pengabdian ini adalah kegiatan ini bisa memberikan manfaat yang besar bagi mahasiswa yakni dengan memberikan edukasi tentang artikel ilmiah dan teknik menyusun artikel ilmiah, prosedur publikasi pada jurnal nasional terakreditasi SINTA serta memotivasi untuk menulis artikel ilmiah dan publikasi di jurnal nasional terakreditasi SINTA.Kata Kunci: Artikel Ilmiah, Publikasi Ilmiah, Akreditasi Jurnal Nasional
SOSIALISASI LITERASI SAINS BERDASARKAN KERANGKA PISA UNTUK PARA PENDIDIK IPA DI INDONESIA
Authors: Setiawan Agung Mulyo , Fardhani Indra , Mulyati Yayuk , Chandra Syahrul , Wulandari Tri , Nida Safwatun 
Published: April 2023

Rendahnya hasil literasi sains siswa Indonesia menjadi sebuah masalah serius. Sebab bangsa Indonesia menempati urutan 70 dari 78 negara di dunia. Oleh karena itu, tujuan kegiatan ini yaitu memberikan sosialisasi literasi sains berdasarkan kerangka PISA untuk para pendidik IPA di Indonesia. Metode yang kami gunakan terdiri dari tahap persiapan, tahap pelaksanaan, serta tahap pelaporan dan publikasi. Hasil tahap persiapan yaitu jadwal, penanggung jawab kegiatan, materi yang disampaikan, dll. Kemudian hasil tahap pelaksanaan yaitu 72,5% peserta yang hadir adalah guru IPA SMP/MTs, 48,8% peserta merasa sangat puas dalam pelaksanaan sosialisasi, akan tetapi 49,8% peserta merasa cukup puas karena menginginkan durasi yang lebih lama. Selanjutnya hasil tahap pelaporan dan publikasi yaitu laporan sudah disusun dalam bentuk hardfile dan softfile, dan salah satu luaran publikasi media massa di laman ‘Tugu Malang’ berhasil dipenuhi dengan baik. Kata Kunci: Literasi sains, PISA, Pendidik IPA
Chemical Characterization and Biological Functions of Hot Alkali-Soluble Crude Polysaccharide from the Water-Insoluble Residue of Macrocybe lobayensis (Agaricomycetes) Fruit Bodies
Authors: Khatua Somanjana , Acharya Krishnendu 
Published: April 2023

<i>Macrocybe lobayensis</i> owe popularity in several traditional cultures not only for delectable taste but also for its nutraceutical profile conveying great health benefits. Previous investigations have enumerated several bioactivities
of the valuable mushroom such as antioxidant, anti-ageing, immune-modulation, and anti-tumor properties where polysaccharides played the key role. Macrofungi polymers are generally isolated by the conventional hot water process discarding the residue which still contains plenty of therapeutic components. The present study thus aimed to re-use such leftover of the edible macrofungus by immersing it in NaOH solution at high temperature supporting circular economy. Consequently a polysaccharide fraction, namely ML-HAP, was isolated that was found to be consisted of a homogenous heteropolysaccharide with molecular weight of &#126; 128 kDa and &#946;-glucan as the chief ingredient as evident by spectroscopy, gel-permeation chromatography, high performance thin-layer chromatography, and Fourier transform infrared. Antioxidant activity assays revealed that the macromolecules possess good radical scavenging, metal ion binding and reducing power. Nevertheless, strong immune-potentiation was also recorded as the extract triggered murine macrophage cell viability, pinocytosis, nitric oxide production and morpho-dynamics within 24 h where the best effect was executed at the level of 100 &#181;g/mL. Altogether, the polysaccharides extracted from <i>M. lobayensis</i> exhibited a potent application prospect in functional food, pharmaceutical, nutraceutical and health care industries that could raise economic value of the underexplored mushroom.
La reforma curricular en la Facultad de Medicina de la Universidad de Antioquia: marco teórico y bases metodológicas
Authors: Gómez Francisco 
Published: April 2023

El progreso científico y técnico y las transformaciones socioculturales exigen una permanente adaptación de la Universidad a las necesidades y demandas de la comunidad y de la práctica profesional. Partiendo de los antecedentes y los aspectos críticos del Modelo Biológico Reduccionista imperante en la práctica contemporánea de la medicina, se expresa la necesidad de formar un médico general con una mirada más amplia que, en su práctica, tenga claramente en cuenta y actúe sobre los aspectos psicoafectivos y socioculturales implícitos en el proceso salud-enfermedad. Se describen, igualmente, algunas propuestas metodológicas que deben ambientar el nuevo currículo, tales como la diversificación de las fuentes de información, la selección de escenarios de aprendizaje, el establecimiento de prioridades en el conocimiento, la vinculación temprana al objeto de estudio y la formación investigativa.
Estado actual de la cirugia general laparoscópica
Authors: Morales Uribe Carlos Hernándo 
Published: April 2023

Los procedimientos laparoscópicos han empezado a reemplazar algunas operaciones convencionales porque evitan la cirugía mayor y se logra una recuperación precoz del paciente. En el futuro muchas cirugías tradicionales se realizarán laparoscópicamente. En este artículo se presenta el estado actual de la cirugía laparoscópica en los siguientes casos: cirugía biliar, úlcera péptica, corrección del reflujo gastroesofágico y de algunos trastornos motores esofágicos, abdomen agudo, herniorrafia inguinal y cirugía colorrectal. Se consignan las ventajas y desventajas en general y para cada caso en particular.