bluuebunny/crossref_metadata_2025_split huggingface dataset:
Facilitating Students' Learning of a Target Construction Through Teacher Interactional Resources in EFL Kindergarten Classrooms
Authors: Tozlu Kılıç Emel , Balaman Ufuk 
Published: January 2023

AbstractThis paper presents research‐led responses to two central questions concerning English as a foreign language (EFL) learning in kindergartens, namely how do the teachers facilitate EFL learning? and how does the impact of certain teacher interactional resources on learning become observable in interaction? Previous research showed that classroom routines facilitate learning, and learners' increased participation through repeating teacher turns is considered as evidence for learning. Using multimodal conversation analysis to examine video‐recorded, face‐masked kindergarten EFL classrooms during the pandemic, we argue that classroom routines transcend repeating teacher turns and create space for learners' contextually meaningful use of target constructions when the teacher introduces such constructions by strategically deploying embodied explanations, translanguaging, choral repetition, understanding checks, repairing dispreferred responses, and designedly incomplete utterances. We adopt a longitudinal perspective to trace one construction in particular, a little bit, and describe how the construction is introduced and routinely circulated by the teacher, and eventually added to a learner's interactional repertoire. The findings offer rich pedagogical implications for EFL kindergarten teachers.
Numerical analysis of Stefan blowing viscous fluid flowing above a stretching/shrinking disk
Authors: Rauf Amar , Mushtaq Tahir , Ansari Munib Qasim , Shehzad Sabir A. , Shehzad Iram , Abbas Z. 
Published: January 2023

AbstractAn incompressible, axi‐symmetric and magnetized viscous fluid flowing above a rotating disk is addressed. The disk can be stretch/shrink with a constant rate along the radial direction. The variable fluid features such as the viscosity, thermal conductivity and mass diffusion are considered in the flow governing equations. Two different cases of mass blowing/suction are considered. In the first case, the injection/suction is considered through the disk surface. The second case of injection/suction is through the surface of the disk by concentration gradient named as the Stefan effect. Similarity variables are accomplished to transform the governing system of partial differential equations into an ordinary one's. The resulting flow model is solved by bvp4c solver. The obtained physical parameters are discussed on velocity, thermal and concentration fields. For the better understanding of the flow phenomenon, the three‐dimensional flow visualization and its two‐dimensional contours against the physical parameters are sketched. The Nusselt and Sherwood numbers and skin‐friction against distinct constraints are calculated. It is observed that the suction parameter decreased the radial velocity curves for the stretching disk, while the velocity profiles are modified along radial direction in case shrinking disk against the increased suction parameter. The skin‐friction coefficient is enhanced for mass injection/suction and Stefan blowing/suction cases against the higher magnetic parameter values. The enhancement in variable thermal conductivity causes a reduction in local‐Nusselt number as well as the Sherwood number.
Black hole information recovery in JT gravity
Authors: Gyongyosi Zsolt , Hollowood Timothy J. , Kumar S. Prem , Legramandi Andrea , Talwar Neil 
Published: January 2023

Abstract
We consider the issue of information recovery for an object carrying energy and entropy into a black hole using the generalized entropy formalism, in the context of JT gravity where the backreaction problem can be solved exactly. We verify the main aspects of the Hayden-Preskill scenario but with some refinements. We show that the information is encoded in the Hawking radiation in a redundant way, as expected for a quantum error correcting code. We show how quantum extremal surfaces associated to information recovery have the form of a python’s lunch and thereby show that the complexity of decoding is exponential in a combination of the entropy shift of the black hole and the entropy of the object. We also show that an infalling observer must have a smooth experience at the horizon and we calculate their endurance proper time inside the black hole before they are radiated out.
Search for lepton flavor violating decay at FASER
Authors: Araki Takeshi , Asai Kento , Otono Hidetoshi , Shimomura Takashi , Takubo Yosuke 
Published: January 2023

Abstract
FASER is one of the promising experiments which search for long-lived particles beyond the Standard Model. In this paper, we consider charged lepton flavor violation (CLFV) via a light and weakly interacting boson and discuss the detectability by FASER. We focus on four types of CLFV interactions, i.e., the scalar-, pseudoscalar-, vector-, and dipole-type interaction, and calculate the sensitivity of FASER to each CLFV interaction. We show that, with the setup of FASER2, a wide region of the parameter space can be explored. Particularly, it is found that FASER2 has a sensitivity to very small coupling regions in which the rare muon decays, such as μ → eγ, cannot place bounds, and that there is a possibility to detect CLFV decays of the new light bosons.
Increase of c-FOS promoter transcriptional activity by the dual leucine zipper kinase
Authors: Köster Kyra-Alexandra , Duque Escobar Jorge , Fietkau Anja , Toledo Regina , Oetjen Elke 
Published: January 2023

Abstract
The dual leucine zipper kinase (DLK) and the ubiquitously expressed transcription factor c-FOS have important roles in beta-cell proliferation and function. Some studies in neuronal cells suggest that DLK can influence c-FOS expression. Given that c-FOS is mainly regulated at the transcriptional level, the effect of DLK on c-FOS promoter activity was investigated in the beta-cell line HIT. The methods used in this study are the following: Luciferase reporter gene assays, immunoblot analysis, CRISPR-Cas9-mediated genome editing, and real-time quantitative PCR. In the beta-cell line HIT, overexpressed DLK increased c-FOS promoter activity twofold. Using 5′-,3′-promoter deletions, the promoter regions from − 348 to − 339 base pairs (bp) and from a − 284 to − 53 bp conferred basal activity, whereas the promoter region from − 711 to − 348 bp and from − 53 to + 48 bp mediated DLK responsiveness. Mutation of the cAMP response element within the promoter prevented the stimulatory effect of DLK. Treatment of HIT cells with KCl and the adenylate cyclase activator forskolin increased c-FOS promoter transcriptional activity ninefold. Since the transcriptional activity of those promoter fragments activated by KCl and forskolin was decreased by DLK, DLK might interfere with KCl/forskolin-induced signaling. In a newly generated, genome-edited HIT cell line lacking catalytically active DLK, c-Fos mRNA levels were reduced by 80% compared to the wild-type cell line. DLK increased c-FOS promoter activity but decreased stimulated transcriptional activity, suggesting that DLK fine-tunes c-FOS promoter-dependent gene transcription. Moreover, at least in HIT cells, DLK is required for FOS mRNA expression.
Defunctioning stoma before neoadjuvant treatment or resection of endoscopically obstructing rectal cancer
Authors: Sandén Gustav , Svensson Johan , Ljuslinder Ingrid , Rutegård Martin 
Published: January 2023

Abstract
Aim
To investigate whether patients with endoscopically untraversable rectal cancer may benefit from a defunctioning stoma created before neoadjuvant therapy or resectional surgery.

Methods
This retrospective study comprise patients diagnosed with rectal cancer during 2007–2020 in Region Västerbotten, Sweden. The primary outcome was time between diagnosis and any treatment, while survival and the incidence of complications were secondary outcomes. Excluded were patients without endoscopic obstruction, patients already having a stoma, patients with recurrent disease, palliative patients, and patients receiving a stoma shortly after diagnosis due to any urgent bowel-related complication. Data were obtained from the Swedish Colorectal Cancer Registry and medical records. Kaplan–Meier failure curves were drawn, and a multivariable Cox regression model was employed for confounding adjustment.

Results
Out of 843 patients, 57 remained after applying exclusion criteria. Some 12/57 (21%) patients received a planned stoma before treatment, and the remainder received upfront neoadjuvant therapy or surgery. Median time to any treatment was 51 days for the planned stoma group and 36 days for the control group, with an adjusted hazard ratio of 0.28 (95% confidence interval: 0.12–0.64). Complications occurred at a rate of 5/12 (42%) and 7/45 (16%) in the planned stoma group and control group, respectively. Survival was similar between groups.

Conclusion
A planned stoma results in treatment delay, but it remains unclear whether this is clinically relevant. Complications were more common in the planned stoma group, although the data are limited. While larger studies are needed, it seems feasible to avoid defunctioning stomas even in endoscopically obstructing rectal cancers.
The endothelial-enriched lncRNA LINC00607 mediates angiogenic function
Authors: Boos Frederike , Oo James A. , Warwick Timothy , Günther Stefan , Izquierdo Ponce Judit , Lopez Melina , Rafii Diba , Buchmann Giulia , Pham Minh Duc , Msheik Zahraa S. , Li Tianfu , Seredinski Sandra , Haydar Shaza , Kashefiolasl Sepide , Plate Karl H. , Behr Rüdiger , Mietsch Matthias , Krishnan Jaya , Pullamsetti Soni S. , Bibli Sofia-Iris , Hinkel Rabea , Baker Andrew H. , Boon Reinier A. , Schulz Marcel H. , Wittig Ilka , Miller Francis J. , Brandes Ralf P. , Leisegang Matthias S. 
Published: January 2023

AbstractLong non-coding RNAs (lncRNAs) can act as regulatory RNAs which, by altering the expression of target genes, impact on the cellular phenotype and cardiovascular disease development. Endothelial lncRNAs and their vascular functions are largely undefined. Deep RNA-Seq and FANTOM5 CAGE analysis revealed the lncRNA LINC00607 to be highly enriched in human endothelial cells. LINC00607 was induced in response to hypoxia, arteriosclerosis regression in non-human primates, post-atherosclerotic cultured endothelial cells from patients and also in response to propranolol used to induce regression of human arteriovenous malformations. siRNA knockdown or CRISPR/Cas9 knockout of LINC00607 attenuated VEGF-A-induced angiogenic sprouting. LINC00607 knockout in endothelial cells also integrated less into newly formed vascular networks in an in vivo assay in SCID mice. Overexpression of LINC00607 in CRISPR knockout cells restored normal endothelial function. RNA- and ATAC-Seq after LINC00607 knockout revealed changes in the transcription of endothelial gene sets linked to the endothelial phenotype and in chromatin accessibility around ERG-binding sites. Mechanistically, LINC00607 interacted with the SWI/SNF chromatin remodeling protein BRG1. CRISPR/Cas9-mediated knockout of BRG1 in HUVEC followed by CUT&RUN revealed that BRG1 is required to secure a stable chromatin state, mainly on ERG-binding sites. In conclusion, LINC00607 is an endothelial-enriched lncRNA that maintains ERG target gene transcription by interacting with the chromatin remodeler BRG1 to ultimately mediate angiogenesis.
The effect of weather and temporal factors on emergency hand trauma consultations
Authors: Illg Claudius , Zoldina Anna , Sarica Louisa , Schäfer Ruth Christine , Daigeler Adrien , Krauss Sabrina 
Published: January 2023

Abstract
Introduction
Fluctuations in the numbers of patient consultations in hand trauma emergency units are challenging in terms of both scheduling and the provision of sufficient resources. Trauma consultations in general are affected by both temporal and meteorological variables. As the genesis and epidemiology of hand trauma have their own characteristics, this study aimed to identify the influence of temporal and meteorological factors on hand trauma consultations.

Materials and methods
All patients treated for hand trauma in our level one trauma center in 2019 were included in the study population and the data were analyzed in retrospect. The daily weather data, including temperature, sunshine duration, precipitation, humidity and wind speed, as well as temporal factors such as time of day, weekday and public holidays were considered and correlated with patient consultations. Gender differences were studied as well.

Results
We included 4787 hand trauma patients (66.4% male, mean age 38.4 ± 19.3 years, 31.7% occupational injuries). Significantly more consultations occurred on Saturdays as compared to weekdays (14.8 ± 0.6, n = 52 vs. 13.0 ± 0.2, n = 261; p = 0.028), and fewer occurred on official holidays (11.8 ± 0.5, n = 63 vs. 13.4 ± 0.2, n = 302; p = 0.0047). We found a significant positive correlation between daily consultations, sunshine duration (r = 0.14, p = 0.0056) and the mean temperature (r = 0.20, p < 0.0001); in contrast, a significant negative correlation between daily consultations and humidity (r = − 0.17, p = 0.001) was observed. Furthermore, fewer consultations were seen on days with precipitation (12.7 ± 0.3, n = 219 vs. 13.8 ± 0.3, n = 146; p = 0.009). The variation was considerably stronger in men.

Conclusions
Hand trauma consultations increased with increasing temperatures, duration of sunshine, and decreasing humidity. Peak admissions were seen on Fridays and Saturdays. These findings can assist in predicting days with peak admissions to allocate resources appropriately.
The outcome of pregnancies after bariatric surgery: an observational study of pregnancies during 2004–2016 in Finland
Authors: Sesilia Kaukonen , Susanna Pajula , Virve Koljonen , Mika Gissler , Veli-Matti Ulander , Marja Kaijomaa 
Published: January 2023

Abstract
Purpose
Overweight and obesity are major risk factors for perinatal morbidity and mortality, and the need for bariatric surgery (BS) among fertile-aged women is increasing. This study evaluates the outcome of post-BS pregnancies and deliveries.

Methods
All 20–45-year-old patients delivering between 2004 and 2016 in Finland were included. Patients with previous BS were identified from the hospital discharge register, and the medical birth register was queried for data on pregnancies, deliveries, and perinatal outcomes. The data were matched using personal identification codes, and the outcomes of women with previous BS were compared with those of other pregnancies.

Results
Women with previous BS (n = 314) constituted the bariatric group. When compared with the non-bariatric group (n = 750,019), they were older (p < 0.001), heavier (p < 0.001) and had more previous pregnancies (p < 0.001). The overall incidence of pregnancy-induced hypertension (p = 0.002), gestational diabetes (GDM) (p = 0.018), pre-term contractions (p = 0.023), pre-term delivery (p = 0.003), labour induction (p < 0.001), planned (p = 0.001) and unplanned (p = 0.036) caesarean sections and low birthweight infants (p < 0.001) were significantly higher in the bariatric group. When compared with body mass index–specific categories, the main outcomes were increased incidence of GDM and small for gestational age (SGA) newborns in the bariatric group.

Conclusion
BS can be considered a safe and advisable treatment for obesity among fertile-aged women. The pregnancy outcome is associated with post-BS weight, but the risk for GDM and small for gestational-age newborns is increased.
Effectiveness of a vitamin D regimen in deficient multiple myeloma patients and its effect on peripheral neuropathy
Authors: Oortgiesen Berdien E. , Dekens Marloes , Stapel Ruud , Alheraky Abdulrazzaq , Dannenberg Pauline de Keizer , Siemes Claire , Jansman Frank G. A. , Kibbelaar Robby E. , Veeger Nic J. G. M. , Hoogendoorn Mels , van Roon Eric N. 
Published: January 2023

Abstract
Purpose

Peripheral neuropathy (PN) is common in multiple myeloma (MM) patients. More insight has been gained concerning the role of vitamin D in preventing PN. However, studies evaluating the effects of vitamin D3 supplementation on PN are lacking. The aims of this study are to (1) evaluate the effectiveness of a vitamin D3 regimen on achieving adequate vitamin D levels in deficient MM patients and to (2) exploratively evaluate the effect of vitamin D3 supplementation on PN.

Methods
Thirty-nine MM patients with inadequate (< 75 nmol/L [= 30 ng/mL]) 25-hydroxyvitamin D (25(OH)D) levels were included in this multicenter, prospective, single-arm study, of whom 35 patients completed the study. They received oral vitamin D3 for 6 months according to a dose escalation regimen that consisted of one or two loading doses of 200,000 international units (IU), and maintenance doses of 800, 1600, or 3200 IU/day depending on the 25(OH)D level. A validated questionnaire was used to measure PN.

Results
Median 25(OH)D increased from 38 (IQR 32–52) nmol/L at baseline to 77 (IQR 72–87) nmol/L after 6 months (P < 0.001). Adequate 25(OH)D levels were achieved by 66% of the subjects, and 34% were within the range of 50–75 nmol/L. Furthermore, in 37% of the participants, PN severity decreased (P = 0.007).

Conclusion
The use of substantially higher vitamin D3 doses than recommended in current guidelines resulted in a significant increase in vitamin D levels in MM patients. Furthermore, evaluation of PN showed a significant decrease in PN grading. However, this exploratory evaluation needs further confirmatory research.
Transformer transfer learning emotion detection model: synchronizing socially agreed and self-reported emotions in big data
Authors: Lee Sanghyub John , Lim JongYoon , Paas Leo , Ahn Ho Seok 
Published: January 2023

AbstractTactics to determine the emotions of authors of texts such as Twitter messages often rely on multiple annotators who label relatively small data sets of text passages. An alternative method gathers large text databases that contain the authors’ self-reported emotions, to which artificial intelligence, machine learning, and natural language processing tools can be applied. Both approaches have strength and weaknesses. Emotions evaluated by a few human annotators are susceptible to idiosyncratic biases that reflect the characteristics of the annotators. But models based on large, self-reported emotion data sets may overlook subtle, social emotions that human annotators can recognize. In seeking to establish a means to train emotion detection models so that they can achieve good performance in different contexts, the current study proposes a novel transformer transfer learning approach that parallels human development stages: (1) detect emotions reported by the texts’ authors and (2) synchronize the model with social emotions identified in annotator-rated emotion data sets. The analysis, based on a large, novel, self-reported emotion data set (n = 3,654,544) and applied to 10 previously published data sets, shows that the transfer learning emotion model achieves relatively strong performance.
Structuring Life After Death: Plant Leachates Promote CO2 Uptake by Regulating Microbial Biofilm Interactions in a Northern Peatland Ecosystem
Authors: Rober Allison R. , Lankford Allyson J. , Kane Evan S. , Turetsky Merritt R. , Wyatt Kevin H. 
Published: January 2023

AbstractShifts in plant functional groups associated with climate change have the potential to influence peatland carbon storage by altering the amount and composition of organic matter available to aquatic microbial biofilms. The goal of this study was to evaluate the potential for plant subsidies to regulate ecosystem carbon flux (CO2) by governing the relative proportion of primary producers (microalgae) and heterotrophic decomposers (heterotrophic bacteria) during aquatic biofilm development in an Alaskan fen. We evaluated biofilm composition and CO2 flux inside mesocosms with and without nutrients (both nitrogen and phosphorus), organic carbon (glucose), and leachates from common peatland plants (moss, sedge, shrub, horsetail). Experimental mesocosms were exposed to either natural sunlight or placed under a dark canopy to evaluate the response of decomposers to nutrients and carbon subsidies with and without algae, respectively. Algae were limited by inorganic nutrients and heterotrophic bacteria were limited by organic carbon. The quality of organic matter varied widely among plants and leachate nutrient content, more so than carbon quality, influenced biofilm composition. By alleviating nutrient limitation of algae, plant leachates shifted the biofilm community toward autotrophy in the light-transparent treatments, resulting in a significant reduction in CO2 emissions compared to the control. Without the counterbalance from algal photosynthesis, a heterotrophic biofilm significantly enhanced CO2 emissions in the presence of plant leachates in the dark. These results show that plants not only promote carbon uptake directly through photosynthesis, but also indirectly through a surrogate, the phototrophic microbes.
RbQE: An Efficient Method for Content-Based Medical Image Retrieval Based on Query Expansion
Authors: Rashad Metwally , Afifi Ibrahem , Abdelfatah Mohammed 
Published: January 2023

AbstractSystems for retrieving and managing content-based medical images are becoming more important, especially as medical imaging technology advances and the medical image database grows. In addition, these systems can also use medical images to better grasp and gain a deeper understanding of the causes and treatments of different diseases, not just for diagnostic purposes. For achieving all these purposes, there is a critical need for an efficient and accurate content-based medical image retrieval (CBMIR) method. This paper proposes an efficient method (RbQE) for the retrieval of computed tomography (CT) and magnetic resonance (MR) images. RbQE is based on expanding the features of querying and exploiting the pre-trained learning models AlexNet and VGG-19 to extract compact, deep, and high-level features from medical images. There are two searching procedures in RbQE: a rapid search and a final search. In the rapid search, the original query is expanded by retrieving the top-ranked images from each class and is used to reformulate the query by calculating the mean values for deep features of the top-ranked images, resulting in a new query for each class. In the final search, the new query that is most similar to the original query will be used for retrieval from the database. The performance of the proposed method has been compared to state-of-the-art methods on four publicly available standard databases, namely, TCIA-CT, EXACT09-CT, NEMA-CT, and OASIS-MRI. Experimental results show that the proposed method exceeds the compared methods by 0.84%, 4.86%, 1.24%, and 14.34% in average retrieval precision (ARP) for the TCIA-CT, EXACT09-CT, NEMA-CT, and OASIS-MRI databases, respectively.