bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modern-style plate tectonics preserved in the Paleoproterozoic paired metamorphic belts driven by cold deep subduction
Authors: Yin Changqing , Xia Yanfei , Cawood Peter , Zhao Guochun , Xiao Wenjiao , Lin Shoufa , Qian Jiahui , Zhang Jian , Gao Peng , Wu Shangjing 
Published: March 2023

Abstract
When modern-style plate tectonics commenced on Earth remains one of fundamental questions in unravelling the evolution of our planet, due to the apparent lack of low-thermal gradients in old metamorphic rocks (< 350 °C/GPa)—a key indicator of modern plate subduction—during the Archaean and Palaeoproterozoic Era. Here we present 2.0 Gyr lawsonite eclogites and associated eclogite-facies garnet-kyanite-chloritoid schists with low-thermal gradients of 265-290°C/GPa from the Kongling Complex in South China through integrated thermodynamic modelling and zircon in situ U-Pb dating. More importantly, a temporally equivalent mafic granulites with high-thermal gradients of ~720 °C/GPa has been also recognized spatially adjacent to those low dT/dP eclogite-facies rocks, integrated as a classic paired metamorphic belt. The results show a new discovery of Paleoproterozoic classic paired metamorphic belts driven by cold deep subduction in South China, indicating that the modern-style plate tectonics was already operative on Earth by the Palaeoproterozoic.
Dopamine D2 receptors in the extended amygdala scale the optimization of seeking and avoidance behaviors
Authors: Valjent Emmanuel , Castell Laia , Gall Valentine Le , Cutando Laura , Petit Chloé , Puighermanal Emma , Kim Ha-Rang , Jercog Daniel , Tarot Pauline , Tassou Adrien , Harrus Anna-Gabrielle , Rubinstein Marcelo , Nouvian Regis , Rivat Cyril , Besnard Antoine , Trifilieff Pierre , Gangarossa Giuseppe , Janak Patricia , Herry Cyril 
Published: March 2023

Abstract
In mammals, the ability to optimize and select behavioral strategies is a cardinal and conserved psychophysiological feature for maximizing the chances of survival. However, the neural circuits and underlying mechanisms regulating this flexible feature remain yet unsolved. Here, we demonstrate that such optimization relies on dopamine D2 receptors (D2R) within a subcircuit spanning across the extended amygdala (EA) and the tail of the striatum (TS). Using a mouse model carrying a temporally controlled deletion of D2R within a subcircuit defined by WFS1 neurons, we found that intact EA D2R signaling is necessary to regulate homeostasis-dependent food-seeking behaviors in both male and female mice as well as active avoidance learning and innate escape responses in males. Altogether, these findings identify EA and TS D2R signaling as a novel hub through which dopamine optimizes appetitive behaviors and regulates the switch from passive to active defensive behaviors, regardless of learned or innate threats.
Providing a sustainable green model for large sports venues
Authors: Salimi Mehdi , Dadgar Hamid , Taghavy Arezoo 
Published: March 2023

Abstract
The rapid development of industrialization and expansion of urbanization, energy crisis, ecological destruction, environmental environment, and such issues have always been an environment for the survival and growth of human life. In recent years, the sport has been proposed as an engine of sustainable development, recognized as one of the most critical capabilities of sustainable development to promote environmental protection. The current research aimed to provide a sustainable green model for large sports venues. The method of conducting this qualitative and the Statistical research population included specialists in the research field. The statistical sample was selected by the snowball method, and their number reached 15 people. The tool and method of data collection was an individual semi-structured interview. For data analysis, Glaser's grounded theory approach was used, including two main steps actual and theoretical coding. 465 primary codes, 72 categories, and 10 main concepts were identified during the actual coding process. Among the most essential extracted concepts, we can mention cultural factors, structural stability, national and ethnic identity, green management, recycling, transportation, and traffic. In the theoretical coding stage, the final model of the research was drawn, focusing on presenting a sustainable green model of large sports venues. The development and presentation of the sustainable green model of sports venues have increased awareness in designing and building large stadiums and led to the construction of structures following the sustainability of the environment.
Chaotic behavior and exact traveling wave solutions for the fractional stochastic Bogoyavlenskii equation with multiplicative noise
Authors: Han Tianyong , Zhang Kun , Tang Chao 
Published: March 2023

Abstract
In this paper, the conformal fractional derivative and the Stratonovich integral are used to investigate the fractional stochastic Bogoyavlenskii equation with multiplicative noise. Using the dynamic system method, the chaotic behavior, sensitivity, and precise traveling wave solutions are provided. This study presents a complete investigation of the periodic, quasi-periodic, chaotic, and sensitive behavior using perturbations analysis, phase trajectory analysis, time series, and Poinca\'{r}e section. A number of novel traveling wave solutions are developed, including Jacobian elliptic functions, exponential and hyperbolic functions. The effect of multiplicative noise and fractional derivatives on the solution is then examined using a comparative analysis technique. The results show that the fractional derivative and random noise have a considerable impact on how the model behaves. The methods and results in this paper are useful and can be applied to studies of even more complicated phenomena.
Relationship of life-satisfaction and self-efficacy with prognostic markers in patients undergoing hemodialysis: a cross-sectional study
Authors: Kondo Kaoru , Nagai Kojiro , Shima Hisato , Yokota Narushi , Minagawa Naoto , Koezuka Yasuhiko , Ichien Go , Doi Toshio , Minakuchi Jun 
Published: March 2023

Abstract
Background
A questionnaire related to patients’ physical condition is required to assess their quality of life and improve their self-management skills.
Methods
It was a descriptive, cross-sectional, multicenter study that aimed to assess the life-satisfaction and self-efficacy questionnaires verified in Japan, which were related to physical parameters in patients undergoing hemodialysis. A total of 196 outpatients receiving hemodialysis at four dialysis centers were included in the study. Responses to life-satisfaction and self-efficacy questionnaires were collected. Demographic and clinical characteristics of patients were obtained, including life circumstances, in addition to nutritional indices such as normalized protein catabolic rate, creatinine generation rate, and geriatric nutritional risk index.
Results
Life-satisfaction scores were related to prognostic physical parameters, such as normalized protein catabolic rate and creatinine generation rate. Female sex, non-diabetic status, and working patients were more satisfied with their lives undergoing hemodialysis. Elderly patients had higher self-efficacy scores, which were related to their life-satisfaction. However, the self-efficacy scores were not associated with physical parameters.
Conclusions
This life-satisfaction questionnaire is simple and related to the patient’s condition.
Major urinary protein 1 acts as a critical molecule in empathy regulation
Authors: Zhao Ming-Gao , Zhang Kun , Song Da , Feng Ban , Qi Jinyu , Gui Jia , Ma Shan , Yang Qi , Yang Le , Cui Long , Chen Yan , Wang Min , Wang Xin , Liu An , Wu Yu-Mei , Liu Shui 
Published: March 2023

Abstract
Emotional contagion is believed to be the evolutionary basis of empathy. Recently, empathy was also confirmed to exist in rodents. However, the underlying mechanism of empathy remains elusive. Using a social defeat model, we found that depressive emotion can be transmitted between cagemates in mice through odor cues. Odors from defeated mice containing information about danger induced social avoidance, producing a force opposite from social orientation in naïve mice. The medial prefrontal cortex (mPFC) chooses between flight or approach after evaluating these two forces. mPFC activation is stronger in high-empathy (or high-social orientation) mice than in low-empathy (or low-social orientation) mice. Major urinary protein 1 (MUP1), reported as a pheromone, contributes to stronger mPFC activation in higher-empathy mice. MUP1 increases mPFC neuronal excitability by binding with neuronal syntaxin-binding protein 1 (STXBP1) and astrocytic excitatory amino acid transporter 2 (GLT1). Human progestagen–associated endometrial protein (hPAEP), an MUP1 homologous analog in humans, is decreased in children with autistic spectrum disorder (ASD), and reduced hPAEP level in plasma correlates with behavioral abnormity in ASD children. Existing studies have identified MUP1 as a critical molecule in empathy regulation and a potential target for treating disorders characterized by empathy disabilities, such as ASD.
High levels of chromosomal synteny in 250 million year old groups of dragonflies and damselflies (Insecta:Odonata)
Authors: Tolman Ethan , Beatty Christopher , Bush Jonas , Kohli Manpreet , Frandsen Paul , Gosnell J. , Ware Jessica 
Published: March 2023

Abstract
Using recently published chromosome-length genome assemblies of damselfly species Ischnura elegans and Platycnemis pennipes and dragonfly species Pantala flavescens and Tanypteryx hageni, we demonstrate that the autosomes of Odonata show a high level of conservation, despite 250 million years of separation. In the four genomes discussed here, our results show that all autosomes have a clear homolog to the ancestral karyotype. Despite clear synteny, we demonstrate that different factors, including concentration of repeat dynamics, GC content, and the relative proportion of coding sequence all influence the amount of synteny across chromosomes, and that the influence of these factors differ among species. Micro- and sex chromosomes in Odonata do not share the same level of synteny as autosomes. Of the four species sampled, the genome of the Black Petaltail, which diverged from its sister species 70 million years ago, is a clear outlier, showing similarities to other long-lived lineages.
Optimized Pixel Level Image Fusion for Lung Cancer Detection Over Mri and Pet Image
Authors: Nair Lekshmi v , Jerome S. Albert 
Published: March 2023

Abstract
Lung cancer is an abnormal development of cells that are uncontrollably proliferating. When using a system for medical diagnostics, the precise identification of lung cancer is crucial. Magnetic Resonance Imaging (MRI) and Positron Emission Tomography (PET) are the most common methods for diagnoses. Due to the limited sensitivity of the border pixels in PET and MRI imaging, finding lung cancer might be difficult. As a result, image fusion was created, which successfully combines several modalities to identify the disease and cure it. But merging images from multiple modalities has always been troublesome in medicine because the final image includes distorted spectral information. The ideal pixel-level image fusion approach to merge lung cancer images obtained from several modalities is provided in this research to circumvent the issue. Pre-processing, multi-modality image fusion, feature extraction, and classification are the four phases of the suggested methodology. Images from the PET and MRI scanners are initially gathered and prepared. The best pixel-level fusion method is then used to merge the PET and MRI images. Here, the adaptive tee seed optimization (ATSO) method is used to ideally choose the fusion parameter contained in the approach to improve the fusion model. The texture characteristics are taken from the fused image after the image fusion procedure. The deep extreme learning machine (DELM) classifier will then identify animage as normal or abnormal using the retrieved characteristics.Utilizing a variety of criteria, the effectiveness of the suggested methodology is assessed and compared to previous state-of-art studies.
The blood pressure targets in survivors of cardiac arrest: a systematic review and meta- analysis
Authors: Xie Ying , Geng Yu , Gao Tong , Li Siyuan , Bi Lei , Wang Yintang , Zhang Ping 
Published: March 2023

Abstract
Background
The patients with return of spontaneous circulation post cardiac arrest have a mortality rate of up to 30-50%. Hemodynamic support is a key component of out-of-hospital cardiac arrest (OHCA) management and is essential to ensure survival. The meta-analysis was performed to investigate the optimizing blood pressure targets in survivors of OHCA.
Methods
Studies were searched in electronic databases from January 1, 2015 to January 13, 2023. Results were pooled using random effects model and fixed effects model and are presented as odd ratios (ORs) with 95% confidence intervals (CI). The primary outcome was all-cause death and the secondary outcome were severe bleeding, arrhythmia, renal replacement therapy, cerebral performance category (CPC) score≥3, modified Rankin Scale (mRS) score≥4 and the level of serum norepinephrine, neuron-specific enolase (NSE), troponin T.This study was registered with INPLASY 2022120065.
Results
Four studies involving 1,327 participants were included. No significant differences of the risk of all-cause death were found between the low-target blood pressure and high-target blood pressure strategy (OR 0.93 [95% CI 0.73–1.17], I²=0%, P=0.55). Meanwhile, the low-target blood pressure therapy had a higher proportion of mRS score≥4 (OR 0.43 [95% CI 0.20–0.94], I²=0%, P=0.03) ≥4 compared with the high-target blood pressure therapy. No significant between-group differences were identified among patients in the level of the serum NSE (SD 0.82 [95% CI -1.50–3.13], I²=28%, P=0.49), troponin T (SD 0.54 [95% CI -0.03–1.12], I²=0%, P=0.07), renal replacement therapy (OR 1.09 [95% CI 0.71–1.69], I²=49%, P=0.69), severe bleeding(OR 1.18 [95% CI 0.85–1.65], I²=0%, P=0.33) and arrhythmia(OR 0.84 [95% CI 0.57–1.24], I²=0%, P=0.38).
Conclusions
The higher mean arterial pressure (MAP) is not associated with improved outcome when compared to conventional target, but may be associated with worse neurological outcome.
Automated evaluation of cardiac contractile dynamics and aging prediction using machine learning in a Drosophila model
Authors: Pant Aniket , Melkani Yash , Melkani Girish 
Published: March 2023

Abstract

The Drosophila model has proven tremendously powerful for understanding pathophysiological bases of several human disorders including aging and cardiovascular disease. Relevant high-speed imaging and high-throughput lab assays generate large volumes of high-resolution videos, necessitating next-generation methods for rapid analysis. We present a platform for deep learning-assisted segmentation applied to optical microscopy of Drosophila hearts and the first to quantify cardiac physiological parameters during aging. An experimental test dataset is used to validate a Drosophila aging model. We then use two novel methods to predict fly aging: deep-learning video classification and machine-learning classification via cardiac parameters. Both models suggest excellent performance, with an accuracy of 83.3% (AUC 0.90) and 77.1% (AUC 0.85), respectively. Furthermore, we report beat-level dynamics for predicting the prevalence of cardiac arrhythmia. The presented approaches can expedite future cardiac assays for modeling human diseases in Drosophila and can be extended to numerous animal/human cardiac assays under multiple conditions.
Significance
· Current analysis of Drosophila cardiac recordings is capable of limited cardiac physiological parameters and are error-prone and time-consuming.
· We present the first deep-learning pipeline for high-fidelity automatic modeling of Drosophila contractile dynamics.
· We present methods for automatically calculating all relevant parameters for diagnosing cardiac performance in aging model.
· Using the machine and deep learning age-classification approach, we can predict aging hearts with an accuracy of 83.3% (AUC 0.90) and 77.1% (AUC 0.85), respectively.
Genome-resolved metagenomics of milk microbiomes reveals the influence of maternal dietary fiber on neonatal inheritance of immunoregulatory traits
Authors: Dennis Paul , Hoelzle Robert , Rashid Ridwan , Sikder Md Al Amin , Lyons Rebecca , Stark Terra , Phipps Simon 
Published: March 2023

AbstractBreastfeeding facilitates vertical transmission of microbes from mothers to infants. Milk microbiome composition is strongly influenced by maternal diet, and this affects which taxa are likely to colonize the infant gut with consequences for host health and immune development. At present, it is unclear how diet influences the composition of the milk microbiome and why these microbes lead to different health outcomes for the infant. Here, we used metagenomics and metabolomics to link microbially-mediated immunoregulatory traits and metabolites to individual milk microbial taxa, and determine how the representation of these traits changes with maternal dietary fiber content. We assembled and annotated genomes accounting for 90% of the milk microbial communities from breastfeeding mice fed high or low-fiber chow. Diverse carbohydrate and fatty acid content in high-fiber milk was associated with diverse microbes harboring multiple glycoside hydrolases and high redundancy of immunoregulatory metabolite pathways. Low dietary fiber, by contrast, produced milk enriched in amino acids and a low-diversity peptide degrading microbiome with limited immunoregulatory traits. Our study indicates that complex milk carbohydrate availability drives assembly of a diverse milk microbiome, and by extension a diverse set of immunoregulatory functions inheritable by the breastfeeding infant. Collectively, our findings highlight how the mother’s diet influences the composition of the milk microbiome and the potential vertical transmission of immunoregulatory traits from mother to infant.
Polarization Reconfigurable Sequentially Rotated Dielectric Resonator Antenna Array
Authors: qasaymeh yazeed 
Published: March 2023

Abstract
In this article, a miniaturized dielectric resonator antenna (DRA) array is presented in which the polarization can be altered between right-hand circular polarization (RHCP) and left-hand circular polarization (LHCP) operating in the IEEE 802.11a band. To enable circular polarization (CP), a novel resonating element is proposed that consists of a rectangular dielectric resonator (RDR) coupled to a hexagonal slot (HS) and fed by a microstrip line. The proposed resonating element that is composed of a hexagonal slot (HS) coupling a rectangular dielectric resonator (RDR) produces two orthogonal degenerate modes, 𝑇𝐸𝑥𝛿32 and 𝑇𝐸𝑦1𝛿1, thus ensuring the existence of CP radiation. To achieve dual circular polarization (DCP) performance, a 2 x 2 sequential rotation (SR) array is prototyped that employs a single rat-race coupler and two branch-line couplers. Polarization agility is attained by utilizing four PIN diodes that are positioned between the rat-race outputs and quadrature coupler inputs and are operated in alternating pairs. Prior to simulation and fabrication, an equivalent impedance circuit of the array is postulated based on the array sub-elements to provide a primary resonance attitude of the array. The 76 x 51 mm2 (1.469𝜆0 ×0.986𝜆0) array has an impedance bandwidth of 12.12 % for both polarization states, in conjunction with a 3-dB axial ratio (AR) impedance bandwidth of 11.76 %. The gain variation realized throughout the resonance band ranges from 9.62 to 9.8 dBi. The results for the proposed array indicate that it is suitable for applications operating in the IEEE 802.11a band.
The interaction effects of homeschooling and pandemic-related worries on Chinese parents’ mental health: Are mothers different from fathers?
Authors: liu xiaohan , huang ning , fu mingqi , guo jing 
Published: March 2023

Abstract
Background: Many countries worldwide implemented school closures to reduce COVID-19 transmission. By the new ‘homeschooling’ process, children could continue the regular school curriculum from the software-based system, which could alleviate parents' concerns about their children's educational attainment. However, parents still conduct more basic education and supervision, which may increase parental stress.
Objective: This study aims to examine the interaction effect of homeschooling experience and pandemic-related worries on Chinese parents’ mental health. In addition, whether and how the relationship between homeschooling experience, pandemic-related worries and mental health could vary between women and men was examined.
Method: This study recruited 746 Chinese parents with 10-18-year-old children during the COVID-19 pandemic. Data were analysed with multiple linear regression.
Results: We found a higher level of job-related worries was associated with worse parental mental health (β= 3.593，P<.001). Additionally, the learning process was significantly positively correlated with parental mental health (acceptance of parental homework support β=1.748, P=.003; children’s completion of the studying task β=1.337, P=.018). Job-related worries significantly moderated the relationship between homeschooling and parental mental health (β=2.215, P=.026), while virus-related and life-related worries did not. Regarding gender differences, the interaction effects of job-related worries on the relationship between homeschooling and parental psychological symptoms were only significant among mothers (β=2.579, P=.020).
Conclusion: Homeschooling is significantly associated with Chinese parents’ psychological symptoms. Parental worries are found to moderate the association between homeschooling and parental psychological symptoms. Moreover, job-related worries played a moderating role in the association between homeschooling and parental mental health. Thus, school intervention programs should also be implemented to help children adjust negative learning status in homeschooling.
5hmC immunohistochemistry: a predictor of TERT promoter mutational status in follicular thyroid carcinoma?
Authors: Hysek Martin , Hellgren Samuel , Condello Vincenzo , Larsson Catharina , Zedenius Jan , Juhlin C. Christofer 
Published: March 2023

Abstract
Purpose
TERT promoter mutations and TERT gene expression correlate to adverse prognosis in follicular thyroid carcinoma (FTC), identifying cases at risk of poor outcome. As loss of 5-hydroxymethylcytosine (5hmC) immunoreactivity has been associated with TERT promoter mutations in papillary thyroid carcinoma, this study sought to analyze the levels of 5hmC in a well-characterized cohort of follicular thyroid tumors with available TERT data.
Methods
29 tumors (26 FTCs, 2 follicular thyroid tumors of uncertain malignant potential (FT-UMPs), and one oncocytic thyroid carcinoma) with known TERT promoter mutational status and TERT gene expression levels were assessed for 5hmC immunoreactivity using two monoclonal antibodies (clones RM236 and 4D9.) Slides were analyzed using a semiquantitative scoring system.
Results
Of the 10 tumor cases with a TERT promoter mutation and TERT expression, only one was scored as negative with both antibodies (1/10; 10%), while the remaining 9 cases (9/10; 90%) exhibited various degrees of positivity for at least one antibody. Of the 19 TERT wild-type tumors, no case (0/19; 0%) was scored as negative using the RM236 clone, and two cases (2/19; 11%) using the 4D9 clone. The differences between TERT promoter mutated and wildtype groups were non-significant (Fisher’s Exact test P = 0.35 and 0.59 respectively). The sensitivity and specificity for 5hmC IHC to detect mutated cases were 10% and 100% for RM236 and 20% and 89% for 4D9 respectively.
Conclusion
5hmC IHC is not a highly sensitive marker for the detection of TERT promoter mutations in follicular thyroid tumors. Further analyses in larger cohorts are warranted.