bluuebunny/crossref_metadata_2025_split huggingface dataset:
Apakah Relational Mobility Memprediksi Perubahan Nilai Kerja ? Study Nilai Kerja pada Masyarakat Urban vs. Rural
Authors: Nuzulia Siti , Fikri Rijalul , Tresnaningtyas Dian Rindang , Pamardisiwi Tiara Awanisa , Zian Toriqul 
Published: February 2023

Banyak studi mengatakan bahwa orang-orang dengan relational mobility tinggi memiliki kesempatan untuk membentuk hubungan baru dan mengakhiri hubungan lama dengan mudah. Namun, penelitian yang mengeksplorasi perubahan values ditinjau dari mobilitas individu belum banyak dilakukan. Penelitian ini bertujuan untuk meneliti peran relational mobility terhadap perubahan work values. Penelitian ini menggunakan desain cross-sectional dan menguji 240 partisipan penelitian dengan mengontrol variabel usia dan area tinggal (urban versus rural). Analisis regresi linier dilakukan dua tahap untuk menguji peran relational mobility terhadap work values. Hasil penelitian menunjukkan, relational mobility secara positif memprediksi perubahan work values (terutama nilai achievement, balance, independence, influence, integrity, power, respect, and status) dengan ataupun tanpa mengontrol area tinggal dan usia. Sementara itu, area tinggal dan usia mempengaruhi peran relational mobility terhadap work values, kecuali pada value integrity dan power.Many research investigated that individuals high in mobility have opportunities to form new connections and terminate old ones. However, research that explore values changing in terms of individual’s mobility has not been instigated. This research aimed to investigate the role of relational mobility in changing works values. This study used a cross sectional design to examine 240 participants by controlling age and living area (i.e., urban versus rural). Two steps linear regression was used to examine the role of relational mobility on work values. The result indicated that relational mobility positively predicted a change in most work values (i.e., achievement, balance, independence, influence, integrity, power, respect, and status) with or without controlling living area and age. Meanwhile, living area and age influence the role of relational mobility in work values but not in integrity and power.
Survey of endocrinologists managing recovery from anabolic androgenic steroid induced hypogonadism
Authors: Grant Bonnie , Pradeep Anjali , Minhas Suks , Dhillo Waljit S , Quinton Richard , Jayasena Channa N 
Published: February 2023

Lay summary
Anabolic steroids (also known as ‘steroids’) are banned drugs like testosterone, which make muscles bigger in men. These drugs are dangerous because they stop the testes from making natural testosterone and can cause heart attacks. Men stopping steroids have very low testosterone, which makes them feel weak, depressed, suicidal, infertile, and unable to have erections. We surveyed over 100 doctors to find out how they treat men giving up steroids. We report that doctors differ widely in the way they treat these men. Most doctors simply advise men to wait for the natural recovery of testosterone levels to happen. But 20% of doctors give men drugs to boost testosterone and make men feel better. Unfortunately, many patients had not recovered by the time of our survey. In summary, our survey highlights differences and limitations in the treatment of men giving up steroids. The use of steroids is increasing rapidly among young men, so we recommend further work to improve the treatment of men who are motivated to give up steroids.
Revealing the uterine blood vessel network via virtual pathology
Authors: Kolatt Tsafrir S , Shufaro Yoel , Mashiach Shlomo , Czernobilsky Bernard , Aviel-Ronen Sarit , Apel-Sarid Liat , Dahan Mazal , Or Yuval 
Published: February 2023

Graphical abstract

Abstract

Background
The distribution of the blood vessel network at any point in time in any body tissue may provide valuable information with regard to the tissue condition, whether it is in a growth, declining or recovery phase as well as giving insights as to its angiogenesis functionality. The blood vessel three-dimensional network of the endometrium goes through a process of change over a relatively short period of 4 weeks on average. It is well accepted that angiogenesis within the endometrium is closely related to the success or failure of the implantation of the embryo.

Objective and rationale
Our study aims to present a method to follow the three-dimensional evolution of the superficial blood vessel distribution in the endometrium throughout the uterine cycle.

Method
This method utilizes differences in the observed broadband colors of the blood vessels in order to assess their depth coordinate below the endometrial tissue surface. We implemented the method using microscopic images of fresh, ex vivo, endometrial samples of different cycle days to obtain the statistical evolution track of the superficial blood vessel population in both human and animal (swine) samples.

Outcomes
In human samples, we observed a systematic and consistent trend in the blood vessel diameter distribution at different tissue depths. We demonstrate that the magnitude of this trend evolves throughout the course of the female cycle.

Wider implications
This method has the potential to further our understanding of the mechanisms of angiogenesis in tissues other than the endometrium. We propose that this method may also contribute to more precise endometrial dating and may assist in more accurate determination of embryo transfer timing within in vitro fertilization treatments.

Lay summary
The inner lining tissue of the womb (uterus) is called the endometrium, and it undergoes significant changes during the menstrual cycle.
The endometrium blood vessel network goes through rapid changes during the cycle.
We have developed a new method to measure this through surface imaging of the endometrium.
We use samples of endometrial tissues collected at different dates in the cycle to show how useful this method is in evaluating the development of the endometrium.
The method may also be used to investigate different processes of generating new blood vessels and may help to support dating the development of the endometrium.
Our work offers a non-invasive or minimally invasive method which reveals the three-dimensional blood vessel network and may be used to help in a variety of diagnoses. For example, this method may be used to see how receptive the uterus is during in vitro fertilization treatment.
Organ Protection by Caloric Restriction Depends on Activation of the De Novo NAD+ Synthesis Pathway
Authors: Späth Martin R. , Hoyer-Allo K. Johanna R. , Seufert Lisa , Höhne Martin , Lucas Christina , Bock Theresa , Isermann Lea , Brodesser Susanne , Lackmann Jan-Wilm , Kiefer Katharina , Koehler Felix C. , Bohl Katrin , Ignarski Michael , Schiller Petra , Johnsen Marc , Kubacki Torsten , Grundmann Franziska , Benzing Thomas , Trifunovic Aleksandra , Krüger Marcus , Schermer Bernhard , Burst Volker , Müller Roman-Ulrich 
Published: February 2023

Significance Statement
AKI is a major clinical complication leading to high mortality, but intensive research over the past decades has not led to targeted preventive or therapeutic measures. In rodent models, caloric restriction (CR) and transient hypoxia significantly prevent AKI and a recent comparative transcriptome analysis of murine kidneys identified kynureninase (KYNU) as a shared downstream target. The present work shows that KYNU strongly contributes to CR-mediated protection as a key player in the de novo nicotinamide adenine dinucleotide biosynthesis pathway. Importantly, the link between CR and NAD+ biosynthesis could be recapitulated in a human cohort.

Background
Clinical practice lacks strategies to treat AKI. Interestingly, preconditioning by hypoxia and caloric restriction (CR) is highly protective in rodent AKI models. However, the underlying molecular mechanisms of this process are unknown.

Methods
Kynureninase (KYNU) knockout mice were generated by Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) and comparative transcriptome, proteome and metabolite analyses of murine kidneys pre- and post-ischemia-reperfusion injury in the context of CR or ad libitum diet were performed. In addition, acetyl-lysin enrichment and mass spectrometry were used to assess protein acetylation.

Results
We identified KYNU as a downstream target of CR and show that KYNU strongly contributes to the protective effect of CR. The KYNU-dependent de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis pathway is necessary for CR-associated maintenance of NAD+ levels. This finding is associated with reduced protein acetylation in CR-treated animals, specifically affecting enzymes in energy metabolism. Importantly, the effect of CR on de novo NAD+ biosynthesis pathway metabolites can be recapitulated in humans.

Conclusions
CR induces the de novo NAD+ synthesis pathway in the context of IRI and is essential for its full nephroprotective potential. Differential protein acetylation may be the molecular mechanism underlying the relationship of NAD+, CR, and nephroprotection.
Multiomics Analyses Reveal Sex Differences in Mouse Renal Proximal Subsegments
Authors: Chen Lihe , Chou Chung-Lin , Yang Chin-Rang , Knepper Mark A. 
Published: February 2023

Significance Statement
Sex-dependent differences in kidney function are recognized but the underlying molecular mechanisms are largely unexplored. Advances in genomics and proteomic technologies now allow extensive characterization of differences between the same cell types of males and females. Multiomics integrating RNA-seq, ATAC-seq, and proteomics data to investigate differences in gene expression, chromatin accessibility, and protein expression in proximal tubules of male and female mice identified many sex-biased genes and proteins associated with kidney functions, including metabolic and transport processes. Sex differences may also arise from variations of the interaction between transcription factors and accessible chromatin regions. A comprehensive web resource is provided to advance understanding of sex differences in cells of the proximal tubule.

Background
Sex differences have been increasingly recognized as important in kidney physiology and pathophysiology, but limited resources are available for comprehensive interrogation of sex differences.

Methods
RNA-seq and ATAC-seq of microdissected mouse proximal tubules and protein mass spectrometry of homogenized perfused mouse kidneys reveal differences in proximal tubule cells of males and females.

Results
The transcriptomic data indicated that the major differences in the proximal tubules between the sexes were in the S2/S3 segments, and most of the sex-biased transcripts mapped to autosomes rather than to the sex chromosomes. Many of the transcripts exhibiting sex-biased expression are involved in monocarboxylic acid metabolic processes, organic anion transport, and organic acid transport. The ATAC-seq method on microdissected tubules captured chromatin accessibility. Many of the more than 7000 differentially accessible DNA regions identified were in distal regions. Motif analyses revealed a lack of direct involvement of estrogen receptors or the androgen receptor (absence of canonical hormone response elements), suggesting an indirect regulatory role of sex hormones. Instead, analyses identified several transcription factors (TFs) (Tead1, Nfia/b, and Pou3f3) whose interplay with proximal tubule-specific TFs (e.g., Hnf1b, Hnf4a) may contribute to sex differences. Finally, the whole-kidney proteome was correlated with the transcriptome, and many sex-biased proteins (e.g., Cyp2e1, Acsm2/3) were identified.

Conclusions
Sex-dependent cis-regulatory elements interact with TFs in ways that lead to sex-biased gene expression in proximal tubule cells. These data are provided as a user-friendly web page at https://esbl.nhlbi.nih.gov/MRECA/PT/.
Normal Transaminases in Methamphetamine- and Heroin-Associated Hyperammonemic Encephalopathy
Authors: Dolan Vera F. 
Published: February 2023

Detecting undisclosed methamphetamine and heroin abuse is a challenge for life underwriters and medical directors. A common clinical assumption is that if substance abusers experience liver damage, it will be indicated by elevated serum transaminases. The following case suggests that assumption may not be true for heavy substance abusers who consume no or minimal alcohol.
This report describes a 44-year-old male with long-term use of inhaled combined methamphetamine and heroin (“speedballs”) and minimal alcohol use, whose transaminases remained normal while episodes of acute liver failure and transient hepatic encephalopathy from hyperammonemia were observed. In this case, a fatal motor vehicle accident occurred following the sudden onset of hepatic encephalopathy hours after consuming a “speedball.”
Normal transaminases may not be proof of a normal healthy liver among methamphetamine and heroin abusers.
Seismoacoustic Coupled Signals from the 11 July 2020 Ms 5.1 Tangshan, China, Earthquake
Authors: Yang Xinghao , Jiang Changsheng , Bian Yinju , Su Wei 
Published: February 2023

ABSTRACT
The Ms 5.1 Tangshan earthquake that occurred on 11 July 2020 was recorded by the infrasound array DQS at a source-to-receiver distance of 196 km and an azimuth of 278°. Relatively high-apparent velocity, celerity of epicenter infrasound, and propagation modeling indicate a stratospheric arrival. The backprojection of the epicentral infrasound detection delineates a northeast direction-extended infrasound radiation region with a long axis of about 57 km and a short axis of about 28 km, which is in good agreement with the fault rupture direction. The robustness of the infrasound radiation source location is also tested. The consistency between the spatial distribution of the radiation source and the epicenter confirms that the extended radiating zone around the epicenter excited infrasound signals lasting 2.5 min at a distance of 196 km. A comparison between the backprojected sound pressure level and peak surface pressure derived from measured seismic ground motions shows some disagreement, which may involve propagation path and/or topography around the epicenter. Therefore, these factors should be taken into account when locating the sources of infrasound and estimating the distribution of ground motion. This study shows the ability of infrasound arrays to detect, locate, and research moderate earthquakes and help reconstruct the seismoacoustic coupling in the source region and fault rupture. Moreover, the complexity of the infrasound radiation source and seismoacoustic coupling mechanism is recognized. It is expected that infrasonic observations of moderate earthquakes will increase with the number of infrasound arrays deployed worldwide. Our study is also helpful to the scientific design and optimal layout of infrasound monitoring systems, which will allow for the detection of earthquakes in addition to explosive sources.
Pengembangan Media Podcast pada Aplikasi Spotify sebagai Media Pembelajaran Maharah al- Istima’
Authors: Rahmah Lailana Aulia , Ahsanuddin Mohammad 
Published: February 2023

Abstract: Technology allows innovation in education, such as utilizing podcasts for learning. Podcast is a new alternative to audio-based learning, however, its use has never been developed for listening skill in the Arabic Language Education (ALE) class of Universitas Negeri Malang (UM). This study aims to describe the development process of podcast media and its feasibility using RnD method of Branch’s ADDIE model. This media was tested on 20 students who had taken the Istima' Tsanawy. Data collec­tion is carried out by observation, interviews, needs analysis questionnaires, and response question­naires for product trial results. The results of this study explain the development of podcasts equip­ped with supporting features such as illustrated vocabulary, practice questions in the form of educational games, and evaluation questions. After being developed, this media received a positive response. Students are enthusiastic in learning with podcasts because it is considered fun and different (a new thing), so the learning interest increases. The percentage of due diligence by experts and students gets an average number of 93.7 pecent which was categorized as very valid, meaning that this media can be implemented in the field as a learning medium.
Keywords: podcast, learning media, Arabic listening skill
Abstrak: Teknologi mampu memberikan pembaharuan dalam ranah pendidikan dengan pemanfaatan podcast dalam proses pembelajaran. Podcast merupakan alternatif baru dalam pembelajaran berbasis audio. Penggunaan podcast belum pernah dikembangkan pada pembelajaran Maharah al-Istima’ di kelas Pendidikan Bahasa Arab UM, padahal podcast memiliki banyak keunggulan yang dapat dimanfaatkan sesuai dengan kebutuhan pembelajaran masa kini. Penelitian ini bertujuan untuk mendeskripsikan proses pengembangan media podcast dan kelayakan penggunaannya di lapangan dengan mengguna­kan metode RnD model ADDIE yang dikembangkan oleh Branch. Media ini diujikan kepada 20 maha­siswa yang telah penyelesaikan mata kuliah Istima’ Tsanawy. Pengambilan data dilakukan dengan cara observasi, wawancara, angket analisis kebutuhan, dan angket respon hasil uji coba pro­duk. Hasil penelitian ini memaparkan pengembangan media berupa podcast yang dilengkapi dengan fitur pendukung seperti kosakata bergambar, latihan soal dalam bentuk game edukatif, dan soal evaluasi. Setelah dikembangkan, media ini mendapatkan respon positif di lapangan. Mahasiswa berantusias dalam menerima materi dalam bentuk podcast, karena dianggap menyenangkan dan berbeda (hal yang baru), sehingga minat belajar meningkat karena pembelajaran yang lebih variatif. Presentase dari uji kelayakan oleh para ahli dan mahasiwa mendapatkan jumlah rata-rata 93,7 persen yang dikategorikan sebagai sangat valid, artinya media ini dapat diimplementasikan di lapangan sebagai media pembelajaran.
Kata kunci: podcast; media pembelajaran; maharah al- istima’
Ambiente virtual de aprendizaje ubicuo de la lengua inglesa basado en proyectos
Authors: CASTELBLANCO BARRERA Jenny Viviana , GUAYARA ORTIZ Diana Carolina , ROZO BECERRA Diana Carolina 
Published: February 2023

En este documento se presenta una propuesta de diseño de una aplicación móvil para el aprendizaje activo de lengua inglesa en estudiantes adultos de nivel inicial de un programa de educación continua. En este ambiente virtual se integran las cuatro habilidades lingüísticas a partir del aprendizaje basado en proyectos. En primer lugar, se describe la población y sus necesidades formativas, así como los referentes teóricos. En segundo lugar, se presenta la caracterización de la aplicación en sus aspectos técnicos y pedagógicos.Finalmente, se discute el aporte de esta propuesta para la innovación educativa.
Palabras clave: Lenguas extranjeras, aprendizaje móvil, Aprendizaje Basado en Proyectos (APB), aprendizaje activo, aprendizaje en adultos, Ambientes Virtuales de Aprendizaje (AVAs).
What every EFL Instructor Needs to Know: Effective Implementation of Needs Analysis
Authors: Trendak-Suślik Olga 
Published: February 2023

One of the first issues that any foreign language teacher needs to take into consideration prior to commencing on their language course is the implementation of a comprehensive learner needs analysis (NA) also referred to as needs assessment. Garnering information on, among others, students’ learning preferences, their previous learning experience or their goals is pivotal in order to design a course that would cater to students’ different needs and meet their expectations. A one-size-fits-all approach is not in line with the reality of language teaching in the 21st century, hence the need for the introduction of NA during language classes.
The aim of the following article is to explore the area of needs analysis – examine its beginnings and further development; define its basic components and also investigate the different data-collection instruments language teachers have at their disposal. The article will also present the results of a pilot study exploring Polish teachers’ perspectives on the introduction of needs analysis in the foreign language classroom.
Methods to Treat Postpartum Hemorrhage: State of the Science
Authors: Kurilla Nancy A. 
Published: February 2023

Objective:Postpartum hemorrhage (PPH) is the leading cause of global maternal death. PPH affects roughly 5% of births worldwide. PPH rates are increasing at alarming rates in many developed countries. This manuscript aims to explore the natural, therapeutic, and economical approaches to breastfeeding, breast and nipple stimulation, and skin-to-skin contact (SSC) as a conventional practice, along with commonly used methods for managing PPH.Method:A total of five articles published in the last 8 years were reviewed, focusing on breastfeeding or breast and nipple stimulation to prevent or treat PPH.Results:SSC and breast and nipple stimulation successfully managed PPH just as well or better than the standard treatment of synthetic oxytocin.Conclusion:Allowing the newborn to have SSC with the new mother through breastfeeding or using a breast pump releases natural oxytocin. Along with standard PPH treatment, this could prove to be an effective standard of care in the event of PPH.
Analgesic Role of Breastfeeding: Analysis of Effectiveness, Implementation Barriers, and Strategies to Promote Evidence-Based Practice
Authors: Hirani Shela Akbar Ali , Ratushniak Adrienne 
Published: February 2023

Objective:Exposure to painful stimuli serves as toxic stress for infants, increasing their subsequent pain sensitivity and resulting in neurodevelopmental impairments. Besides offering nutritional, psychological, immunological, and economic benefits, breastfeeding is reported as the most effective analgesia for the management of minor procedural pain in infants. Although breastfeeding holds several advantages, implementation of this nonpharmacological intervention is still uncommon in many clinical settings.Methods:This scoping review presents an analysis of 29 clinical trials that compare the effectiveness of breastfeeding with other nonpharmacological methods.Findings:Breastfeeding is an efficacious analgesia compared with sucrose, sweet solutions, and other nonpharmacological methods. When used alone or in combination with other nonpharmacological interventions, breastfeeding reduces infants’ biobehavioral responses to pain and promotes faster physiologic recovery after painful procedures. Breastfeeding is recommended as the first choice whenever feasible. Barriers to the uptake of this effective pain management method in clinical practice include misinformation/inconsistent use of evidence, an infant’s impaired sucking reflex, maternal–child separation, the workload of healthcare professionals, a lack of parental involvement, assumptions of healthcare providers, and a lack of adequate information/guidance for parents. Strategies to promote the uptake of breastfeeding for the management of procedural pain in infants include an effective partnership between healthcare providers and breastfeeding mothers, knowledge mobilization resources in multiple languages, informational support and media campaigns, and experiential learning opportunities for breastfeeding mothers.Conclusions:Successful implementation of baby-friendly hospital initiatives, a patient-centered approach, family-centered care, and the collaborative efforts of healthcare providers in all healthcare settings is recommended to promote the uptake of breastfeeding as analgesia.