bluuebunny/crossref_metadata_2025_split huggingface dataset:
P2Y12 Inhibition Suppresses Proinflammatory Platelet–Monocyte Interactions
Authors: Barrett Tessa J. , Berger Jeffrey S. , Rolling Christina C. , Sowa Marcin A. , Wang Tricia T. , Cornwell MacIntosh , Myndzar Khrystyna , Schwartz Tamar , El Bannoudi Hanane , Buyon Jill 
Published: January 2023

Background Monocyte–platelet aggregates (MPAs) represent the crossroads between thrombosis and inflammation, and targeting this axis may suppress thromboinflammation. While antiplatelet therapy (APT) reduces platelet–platelet aggregation and thrombosis, its effects on MPA and platelet effector properties on monocytes are uncertain.
Objectives To analyze the effect of platelets on monocyte activation and APT on MPA and platelet-induced monocyte activation.
Methods Agonist-stimulated whole blood was incubated in the presence of P-selectin, PSGL1, PAR1, P2Y12, GP IIb/IIIa, and COX-1 inhibitors and assessed for platelet and monocyte activity via flow cytometry. RNA-Seq of monocytes incubated with platelets was used to identify platelet-induced monocyte transcripts and was validated by RT-qPCR in monocyte-PR co-incubation ± APT.
Results Consistent with a proinflammatory platelet effector role, MPAs were increased in patients with COVID-19. RNA-Seq revealed a thromboinflammatory monocyte transcriptome upon incubation with platelets. Monocytes aggregated to platelets expressed higher CD40 and tissue factor than monocytes without platelets (p < 0.05 for each). Inhibition with P-selectin (85% reduction) and PSGL1 (87% reduction) led to a robust decrease in MPA. P2Y12 and PAR1 inhibition lowered MPA formation (30 and 21% reduction, p < 0.05, respectively) and decreased monocyte CD40 and TF expression, while GP IIb/IIIa and COX1 inhibition had no effect. Pretreatment of platelets with P2Y12 inhibitors reduced the expression of platelet-mediated monocyte transcription of proinflammatory SOCS3 and OSM.

Conclusions Platelets skew monocytes toward a proinflammatory phenotype. Among traditional APTs, P2Y12 inhibition attenuates platelet-induced monocyte activation.
Personalization @ scale in airlines: combining the power of rich customer data, experiential learning, and revenue management
Authors: Guerrini Alberto , Ferri Gabriele , Rocchi Stefano , Cirelli Marcelo , Piña Vicente , Grieszmann Antoine 
Published: January 2023

AbstractRecently, several macro trends have converged to provide airlines new opportunities for one-to-one digital customer engagement and personalization. Airlines have more types and volumes of data available than ever before: shopping-behavior data, data providing context on booking decisions, social media data enriching the information available on travel trends, and more. All of these can play a critical role in defining the right offers and setting the right prices for each shopping request. A plethora of advanced AI and ML techniques have become available on open-source platforms, letting players generate actionable customer insights and leverage vast amounts of existing data. New distribution technology is being deployed to allow airlines to implement real-time retailing capabilities. Consumers have been trained by the likes of Amazon, Netflix, Alibaba, and Starbucks to expect products and services tailored to their individual needs along with superior and engaging content. This paper presents different approaches to price-product personalization that have been tested in airline cases globally. It also explores how the concept of experiential learning is nicely suited to tackling scenarios in which the purchaser is well-identified as well as cases in which not much is known about the visitor except the context of the shopping session.
Double piezoelectric defects in phononic crystals for ultrasonic transducers
Authors: Jo Soo-Ho , Lee Donghyu , Yoon Heonjun , Youn Byeng D 
Published: January 2023

Abstract
Significant prior research has explored elastic wave-energy localization via defect modes of phononic crystals (PnCs). The integration of defect-introduced PnCs and piezoelectric materials has paved the way for the development of new conceptual products for applications in energy harvesters, wave filters, and ultrasonic sensors. Recently, an attempt has been made to deviate from this paradigm and design an ultrasonic transducer that generates elastic waves. Unfortunately, previous work has been limited to a single-defect situation. Therefore, as an advanced approach, the present work aims to expand the PnC design space into double defects, which will make ultrasonic transducers useful at several frequencies. As a first step, this study targets longitudinal wave generation. To predict the wave-generation performance, a previous analytical model that was built for energy-harvesting purposes under a single-defect situation is modified to be suitable for the present wave-generation purpose under a double-defect situation. Moreover, two parametric studies are executed to analyze how the output responses change based on changes to the input voltage setting and the spacing between the double defects. We hope that these ultrasonic transducers could be potentially applicable for nondestructive testing in structural health monitoring and ultrasonic imaging in medical science.
Realization of valley-spin polarized current via parametric pump in monolayer

MoS2
Authors: Wang Kai-Tong , Wang Hui , Xu Fuming , Yu Yunjin , Wei Yadong 
Published: January 2023

Abstract
Monolayer

M
o
S

2

is a typical valleytronic material with valley-spin locked valence bands. We numerically investigate the valley-spin polarized current in monolayer

M
o
S

2

via adiabatic electron pumping. By introducing an exchange field to break the energy degeneracy of monolayer

M
o
S

2

, the top of its valence bands is valley-spin polarized and tunable by the exchange field. A device with spin-up polarized left lead, spin-down polarized right lead, and untuned central region is constructed through applying different exchange fields in the corresponding regions. Then, equal amount of pumped currents with opposite valley-spin polarization are simultaneously generated in the left and right leads when periodically varying two pumping potentials. Numerical results show that the phase difference between the pumping potentials can change the direction and hence polarization of the pumped currents. It is found that the pumped current exhibits resonant behavior in the valley-spin locked energy window, which depends strongly on the system size and is enhanced to resonant current peaks at certain system lengths. More importantly, the pumped current periodically oscillates as a function of the system length, which is closely related to the oscillation of transmission. The effects of other system parameters, such as the pumping amplitude and the static potential, are also thoroughly discussed.
Multiscale modeling of complex fluids under SAOS and LAOS using a combined FENE transient network model
Authors: Vargas R O , Gómez-López A , Escandón J P , Mil-Martínez R , Phillips T N 
Published: January 2023

Abstract
The multiscale modeling of complex fluids under small and large amplitude oscillatory shear flow using non-linear kinetic and transient network models is presented. The kinetics of microstates is analogous to chemical kinetics, which defines the physical macromolecule interaction in a Newtonian fluid, and the concentration of microstates defines a variable maximum length of extension for each microstate. The effect of important parameters like viscosity ratio, chain length, viscoelasticity, kinetic rate constants, for different initial entanglement scenarios (entangled, disentangled and aleatory) are analyzed. The Lissajous curves for the shear stress and the first normal stress difference versus the instantaneous strain or strain-rate are shown. The self-intersection of the Lissajous curves or secondary loops is shown to depend on the kinetic rate constants, the maximum extension length, and the elasticity.
Experimental study on the correlation between erosion microstructure and performance degradation of hydraulic servo spool valve
Authors: Liu Xinqiang , Ji Hong , Liu Fei , Li Nana , Wang Cong , Lin Guang 
Published: January 2023

Abstract
Surface topography plays an important role in determining the performance of hydraulic components, which often leads to component failure. The dual nozzle electro-hydraulic servo valve is composed of torque motor, pilot nozzle flapper valve and servo spool valve, whereas the failure is at the level of servo spool valve. In more details, the degradation of the static characteristic parameters of the hydraulic servo valve, which is experimentally studied by artificially controlling the fillet radius of the spool working edges, is one of these failures. In addition, the microstructure characteristics of the MOOG J761 valve working edges and the circumferential distribution law of the fillet radius are obtained. The research shows that valve orifice erosion caused fillet on the working edges and increases the dispersion of the circumferential distribution. The erosion micromorphology of the working edge is mainly characterized by surface peeling, notches, grooves, and chamfers. The average and variance of the fillet of the spool working edge at the high-pressure oil exceed those of the working edge of the return oil. When the average fillet radius of the working edge increases by 2.71 times and the average fillet variance increases by 2.55 times, the maximum leakage increases by 5.08 times, the flow gain decreases, and the positive and negative flow gains are asymmetric, decreasing by 7.78% and 1.75%, respectively. The pressure gain decreases significantly by 40.30%. The relation between the microstructure of the orifice working edge and the performance degradation provides a new idea for the performance evaluation and manufacture of hydraulic spool servo valve.
The impact of valley profile on the mobility and Kerr rotation of transition metal dichalcogenides
Authors: Sohier Thibault , de Melo Pedro M M C , Zanolli Zeila , Verstraete Matthieu Jean 
Published: January 2023

Abstract
The transport and optical properties of semiconducting transition metal dichalcogenides around room temperature are dictated by electron–phonon scattering mechanisms within a complex, spin-textured and multi-valley electronic landscape. The relative positions of the valleys are critical, yet they are sensitive to external parameters and very difficult to determine directly. We propose a first-principles model as a function of valley positions to calculate carrier mobility and Kerr rotation angles, and apply it to MoS2, WS2, MoSe2, and WSe2. The model brings valuable insights, as well as quantitative predictions of macroscopic properties for a wide range of carrier density. The doping-dependent mobility displays a characteristic peak, the height depending on the position of the valleys. In parallel, the Kerr rotation signal is enhanced when same spin-valleys are aligned, and quenched when opposite spin-valleys are populated. We provide guidelines to optimize and correlate these quantities with respect to experimental parameters, as well as the theoretical support for in situ characterization of the valley positions.
Lateral resolution enhanced interference microscopy using virtual annular apertures
Authors: Lehmann Peter , Hüser Lucie , Stelter Andre , Kusserow Thomas 
Published: January 2023

Abstract
The lateral resolution in microscopic imaging generally depends on both, the wavelength of light and the numerical aperture of the microscope objective lens. To quantify the lateral resolution Ernst Abbe considered an optical grating illuminated by plane waves. In contrast, the Rayleigh criterion holds for two point sources or point scatterers separated by a lateral distance, which are supposed to emit spherical waves. A portion of each spherical wave is collected by the objective lens and results in an Airy disc corresponding to a diffraction limited intensity point spread function (PSF). If incoherent illumination is employed the intensity PSFs related to different scatterers on an object are added resulting in the well-known Rayleigh resolution criterion. In interference microscopy instead of the intensity the electric field scattered or diffracted by an object will be affected by the transfer function of the optical imaging system. For a reflective object the lateral resolution of an interference microscope can be again characterized by the Abbe limit if the object under investigation is a grating. However, if two irregularities on a flat surface are being imaged the resolution no longer obeys the Rayleigh criterion. Instead, it corresponds to an optical system with an annular aperture and thus surpasses the prediction given by the Rayleigh criterion. This holds true for both, amplitude as well as phase objects, as it will be elucidated in this study by theoretical considerations, simulation results and an experimental proof of principle.
Proton pump inhibitors: Understanding the associated risks and benefits of long-term use
Authors: Thurber Kristina M , Otto Ashley O , Stricker Shawna L 
Published: January 2023

AbstractPurposeProton pump inhibitors (PPIs) are widely prescribed medications. Various adverse clinical effects of PPIs have been reported in the literature, particularly over the past decade. The purpose of this article is to review published data primarily describing adverse effects associated with PPI use and to help clinicians determine which patients may still benefit from therapy despite safety concerns.SummaryAssociations between PPIs and the following have been described: bone fracture, acute and chronic kidney disease, gastrointestinal infections, deficiencies in vitamin B12 and magnesium, and coronavirus disease 2019 and respiratory infections. For inclusion in this review, studies must have evaluated potential adverse events associated with PPIs as a primary or secondary objective. Increased risks of bone fracture, acute and chronic kidney disease, gastrointestinal infections, and magnesium deficiency were consistently reported, albeit mostly in studies involving low-quality data (case-control and/or observational studies) and subject to bias. In the only pertinent randomized controlled trial to date, chronic pantoprazole use was associated with a greater risk of enteric infections relative to placebo use; there was no significant between-group difference in any other adverse event evaluated. PPIs continue to be recommended by the American College of Gastroenterology as a first-line treatment for management of gastroesophageal reflux disease and in the acute period following upper gastrointestinal and ulcer bleeding.ConclusionHigher-quality data is needed to better understand PPI-associated risks of the adverse effects listed above. Until then, clinicians may consider greater vigilance with PPI use; however, the data does not demonstrate a need for wide adoption of de-escalation strategies solely out of safety concerns.
scMEGA: single-cell multi-omic enhancer-based gene regulatory network inference
Authors: Li Zhijian , Nagai James S , Kuppe Christoph , Kramann Rafael , Costa Ivan G 
Published: January 2023

Abstract

Summary
The increasing availability of single-cell multi-omics data allows to quantitatively characterize gene regulation. We here describe scMEGA (Single-cell Multiomic Enhancer-based Gene Regulatory Network Inference) that enables an end-to-end analysis of multi-omics data for gene regulatory network inference including modalities integration, trajectory analysis, enhancer-to-promoter association, network analysis and visualization. This enables to study the complex gene regulation mechanisms for dynamic biological processes, such as cellular differentiation and disease-driven cellular remodeling. We provide a case study on gene regulatory networks controlling myofibroblast activation in human myocardial infarction.

Availability and implementation
scMEGA is implemented in R, released under the MIT license and available from https://github.com/CostaLab/scMEGA. Tutorials are available from https://costalab.github.io/scMEGA.

Supplementary information
Supplementary data are available at Bioinformatics Advances online.
Protein phosphatase 2A deficiency in hippocampal CA1 inhibits priming effect of morphine on conditioned place preference in mice
Authors: Dai Jing , Xie Ran , Sun Zhou-Na , Kou Xiao-Lin , Zhang Jia-Qi , Qi Cui , Liu Rui , Gao Xiang , Wang Jing , Gao Jun 
Published: January 2023

Abstract
Studies have shown that protein phosphorylation plays an important role in morphine abuse. However, the neurobiological mechanism of protein phosphatase 2A (PP2A) underlying the morphine-priming process is still unclear. Here we constructed T29–2-Cre; PP2Afl/fl conditional knockout mice (KO) and investigated the role of hippocampal PP2A in morphine priming. We observed that the deficit of PP2A inhibited the priming behavior of morphine and blocked the priming-induced long-term potentiation (LTP) in the hippocampus of KO mice. Moreover, the expression levels of Rack1 and the membrane GluN2B were significantly reduced in the nucleus accumbens of KO mice compared with those in the control mice, which may be attributed to the decreased HDAC4 in the hippocampus of KO mice. Consistent with it, the similar inhibited priming effects were also observed in the wild-type mice treated with sodium butyrate (NaB)—a nonspecific inhibitor of histone deacetylases—3 h after morphine administration. Taken together, our results suggest that hippocampal PP2A may be involved in morphine priming through the PP2A/HDAC4/Rack1 pathway.
Connectomic disturbances in Duchenne muscular dystrophy with mild cognitive impairment
Authors: Cheng Bochao , Xu Huayan , Zhou Hui , Guo Yi , Roberts Neil , Li Na , Hu Xiao , Chen Xijian , Xu Ke , Lan Yu , Ma Xuejing , Cai Xiaotang , Guo Yingkun 
Published: January 2023

Abstract
Duchenne muscular dystrophy (DMD) is frequently associated with mild cognitive deficits. However, the underlying disrupted brain connectome and the neural basis remain unclear. In our current study, 38 first-episode, treatment-naive patients with DMD and 22 matched healthy controls (HC) were enrolled and received resting-sate functional magnetic resonance imaging scans. Voxel-based degree centrality (DC), seed-based functional connectivity (FC), and clinical correlation were performed. Relative to HC, DMD patients had lower height, full Intellectual Quotients (IQ), and IQ-verbal comprehension. Significant increment of DC of DMD patients were found in the left dorsolateral prefrontal cortex (DLPFC.L) and right dorsomedial prefrontal cortex (DMPFC.R), while decreased DC were found in right cerebellum posterior lobe (CPL.R), right precentral/postcentral gyrus (Pre/Postcentral G.R). DMD patients had stronger FC in CPL.R-bilateral lingual gyrus, Pre/Postcentral G.R-Insular, and DMPFC.R-Precuneus.R, had attenuated FC in DLPFC.L-Insular. These abnormally functional couplings were closely associated with the extent of cognitive impairment, suggested an over-activation of default mode network and executive control network, and a suppression of primary sensorimotor cortex and cerebellum-visual circuit. The findings collectively suggest the distributed brain connectome disturbances maybe a neuroimaging biomarker in DMD patients with mild cognitive impairment.
Detraditionalization, mental illness reports, and mental health professional care use in Europe
Authors: Pop Ioana , Roosma Femke , Achterberg Peter 
Published: January 2023

Abstract
In this study, we address the question of whether individuals that live in more detraditionalized countries have higher levels of mental illness and mental health professional care use. We argue that it is meaningful to consider the different facets of detraditionalization, that is the level of secularization, the ethos of personal autonomy, and self-realization, the erosion of traditional gender roles when understanding patterns of mental illness reports and mental health professional care use. We use data collected in 2010 in 25 European countries by Eurobarometer and find that, generally speaking, people living in more detraditionalized countries are more inclined to use mental health professional care, and that they, on average, report less mental illness than people in less detraditionalized countries. Furthermore, not all forms of adversity result in higher levels of mental health professional care use in the more detraditionalized countries. This is the case only for those experiencing financial strain while for those experiencing unemployment or divorce this was not the case. Furthermore, in more detraditionalized countries, the experience of divorce was related to fewer mental illness reports, a result that could be linked to processes such as the erosion of the traditional institution of marriage and the normalization of divorce in these societies.
In vitro and in vivo evaluation of DNase I in reinstating antibiotic efficacy against Klebsiella pneumoniae biofilms
Authors: Sharma Anayata , Rishi Praveen , Singh Rachna 
Published: January 2023

Abstract
Klebsiella pneumoniae is an opportunistic pathogen associated with biofilm-based infections, which are intrinsically antibiotic resistant. Extracellular DNA plays a crucial role in biofilm formation and self-defence, with nucleases being proposed as promising agents for biofilm disruption. This study evaluated the in vitro and in vivo efficacy of DNase I in improving the activity of cefotaxime, amikacin, and ciprofloxacin against K. pneumoniae biofilms. K. pneumoniae ATCC 700603 and a clinical isolate from catheter-related bloodstream infection were cultured for biofilm formation on microtiter plates, and the antibiofilm activity of the antibiotics (0.03–64 mg/L), with or without bovine pancreatic DNase I (1–32 mg/L) was determined by XTT dye reduction test and viable counting. The effect of ciprofloxacin (2 mg/L) and DNase I (16 mg/L) was further evaluated in vitro on 1-cm-long silicon catheter segments, and in a mouse model of subcutaneous catheter-associated infection. Combination with DNase I did not improve the biofilm-preventive capacity of the three antibiotics or the biofilm-eradicating capacity of cefotaxime and amikacin. The biofilm-eradicating capacity of ciprofloxacin was increased by 8-fold and 4-fold in K. pneumoniae ATCC 700603 and clinical isolate, respectively, with DNase I. The combination therapy caused 99% reduction in biofilm biomass in the mouse model.