bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison Of The Accuracy Between Digital And Conventional Impression In Different Multiple Implant Angles At Posterior Mandibular Region Using Innovation 3D Super Imposition Software Program; In Vitro Study
Authors:   , Hongsopa Arisa 
Published: September 2023

Statement of problem: This study aims to compare the accuracy of three-dimensional changes in position and angulation between digital and conventional impression techniques in different angulated implants at the mandibular partial edentulous area with the use of a mandibular partial edentulous reference model with 4 dental implants in different angulations (15 degrees buccally,lingually, mesially, and distally). Conventional and digital impression techniques were used for master model and fabricated 15 conventional master casts and 15 three dimensional printing models. Each scan body was connected with implant or analog to transfer implant positions. All of the master model, master casts, and printing models were scanned with articulating arm computer coordinating measuring machine and evaluated with Polywork software program. Dimensional change of positions and angulations ware calculated and statistically analyzed. Reference Model with 4 angulated implants showed the distance to reference at 23.647, 31.984, 27.865, and 26.995 mm at 37, 36, 46, and 47 area respectively. Conventional method showed distance of 23.943, 32.137, 28.064, and 27.172 mm at 37, 36, 46 and 47area sequentially. Digital method presented with 23.592, 32.238, 27.798, and 26.899 mm at 37, 36, 46, 47 areas consecutively as shown 37, 36, 46, 47 areas of 23.637, 31.984 mm. Angulation measurement presented in reference model were 69.628 at 37 area, 78.455 at 36 area, 75.723 at 46 area, and 78.579 at 47 area. Conventional method displayed angulation of 71.076, 78.404, 75.968, and 77.944 at 37,36, 46, and 47 areas respectively. Digital method exhibited 69.298 and 78.351 at 37and 36 implants, 75.516, and 78.746 in angulation of 46 and 47 implants in digital technique Within the limitation of this vitro study, partially digital impression technique by the 3Shape intraoral scanner with 3D printing models presented significantly superior accuracy of 3- dimensional distance and angulation to conventional one. Conclusion : Angulated dental implants decreased the accuracy of the conventional approach. Both techniques were clinically acceptable to treat the patients. However, the digital technique is recommended to have more accuracy and decreased chair time. A digital impression of angulated implants was presented more accurate than conventional one in both of distance and angulation.
Comparison Of Three Dimensional Accuracy For Surgical Guided Template Fabrication Using Two Different Implant Planning Software Programs
Authors:   , Thitaphanich Natchaya 
Published: September 2023

Statement of problem: Static computer-assisted implantation system (s-CAIS) has been introduced to implant dentistry for decades. According to previous studies, they were recognised the inaccuracies of actual implant position placed via using static computer-assisted implantation system. These inaccuracies result from an accumulation of every step in the workflow from planning to accuracy assessment. Recently, there are multiple implant planning softwares available. coDiagnostiXTM software and Implant StudioTM software are widely used third-party implant planning softwares which claimed to provide predictable implant placement outcome. However, the effect of softwares used on accuracy of guided surgery in anterior maxilla region has not been throughly reported.

Objective: This study intend to evaluate the accuracy of implant position between using coDiagnostiXTM and 3shape Implant studio software programs.

Materials and methods: 30 bone level tapered implants (Straumann) were placed on the single edentulous space maxilla model which has been planned with coDiagnostiXTM and Implant StudioTM software. The samples were divided into two groups according to the planning software used. Then the planned and placed implant position were superimposed. The deviation among two groups were recorded. Data was analyzed using t-test(α = .05).

Results: For coDiagnostiXTM software, statistic revealed mean angular deviations of 1.99 ± 0.96 degrees, mean coronal deviation of 0.57 ± 0.15 mm, and mean vertical deviation of -0.51 ± 0.18 mm. For Implant StudioTM software, mean angular deviations was 2.43 ± 1.26 degrees, mean coronal deviation of 0.51 ± 0.22 mm, and mean vertical deviation of -0.49 ± 0.23 mm. No significant differences were found between two planning software in all parameters, angular deviation, linear coronal deviation, and vertical deviation (P > 0.05)

Conclusions: There is no statistically significant difference between coDiagnostiXTM and Implant StudioTM software.
The validity and reliability of the Patient Health questionnaire 9 in screening poststroke depression
Authors:   , Dajpratham Piyapat 
Published: September 2023

Background: Poststroke depression occurred about 30% during the first five years after stroke. Timely diagnosis and management could facilitate motor recovery and improve independence. The Patient Health Questionnaire 9 (PHQ-9) is one of the best screening tools for poststroke depression. Since specific screening tool has not yet presented in Thailand, the validity and reliability of the PHQ-9 in stroke patients is clinically essential.

Objectives: To study the criterion validity and reliability of the PHQ-9 (Thai version) in screening poststroke depression by comparing to the psychiatric interview as the gold standard.

Material and Methods: First ever stroke patients age 45 years old and above who had duration of stroke from 2 weeks to 2 years were administered with PHQ-9. The gold standard was a psychiatric interview for major depressive disorder. The criterion validity and reliability analyses, and receiver operating characteristic curve analysis were performed.

Results: One hundred and fifteen stroke patients; with mean age 64+10 years old participated. The mean PHQ-9 score elicited was 5.2 + 4.8. According to the DSM-5 criteria; 23 of them (20%) were diagnosed as depressive disorder. The PHQ-9 had satisfactory internal consistency (Cronbach's alpha = 0.78). The categorical algorithm of the PHQ-9 had low sensitivity (0.52) but very high specificity (0.94) and positive likelihood ratio (9.6). Used as a continuous measure, the optimal cut-off score of PHQ-9 >/= 6 revealed a sensitivity of 0.87, specificity of 0.75, positive predictive value (PPV) of 0.46, negative predictive value (NPV) of 0.95, and positive likelihood ratio of 3.5. The area under the curve (AUC) in this study was 0.87 (95%CI=0.78,0.96).

Conclusion: The PHQ-9 has acceptable psychometric properties for screening for poststroke depression with a recommended cut-off score of six or greater.
Explaining barriers and opportunities for recycled pet for food packaging in Thailand through the lenses of organizational environment theory
Authors:   , Sirithorn Natawadee 
Published: September 2023

Currently, some plastic-related companies propose a solution of recycled plastic (rPET) for food packaging as a solution for the plastic problem in Thailand. Therefore, the objective of the thesis is to study business behavior in order to understand the rationale of why some company needs to use rPET for food packaging. This study combined two theories which are the organizational environment theory and the institutional theory of CSR to analyze the effect of the internal and the external environment that influence companies to support rPET food packaging.

The finding indicates that companies’ mission creates an influence on companies to promote rPET for food packaging in Thailand, especially for global companies. Global companies usually have a clear mission to show responsibility to the plastic problem in any country they are operating. Global companies mostly produce and use massive plastic packaging, making them receive more social pressure than local companies. In terms of the external environment, findings reveal the combination between the availability of financial resources and feedstock of post-consumer PET bottle that influence plastic producers to change or resist to change to rPET production. rPET is new in Thailand, and the country has poor waste segregation system. The market of rPET packaging and the feedstock of post-consumer PET bottles are also limited. It is not easy for some producer to produce rPET food packaging. This can be explained by the second factor which is recycling technology for rPET packaging. For the company who have no recycling technology for food-grade rPET, they need technological investment which requires a huge investment. If there is no clear market for rPET packaging and enough feedstock of post-consumer PET bottle, they would not dare to take a risk in investing in the new technology. Also, if any company which does not have a headquarters mission or receive high pressure from NGOs, it is unlikely for them to change from virgin plastic to rPET which has a higher production cost as well
Chin diaspora and their social networks in Thailand : implications for development in Myanmar
Authors:   , Lian Pau 
Published: September 2023

Due to socioeconomic and political reasons, Chin ethnic people from the western part of Myanmar have been migrating to inner part of the country and abroad. Economic growth and requirement of low skill labor in Thailand since the 1980s have been the pull factors for low skill migrants from its neighbors, including Myanmar. Chin people came to Thailand not only for economic opportunities but also for onward migration. The purpose of this research is to explore the social networks of Chin diaspora in Thailand and their implication to the economic and political development of their home community in Myanmar. With that, diaspora concept of Safran (1991) and migrant social networks concept of Weber (2014) were applied in this research.

By using both quantitative and qualitative research methodologies, the research finds out that the Chin diaspora in Thailand, comprised on different sub-ethnic origins who were from different parts of Myanmar, have similar diasporic characteristics, except in the case of their myth of origin. It is found out that they form fellowships usually related to the Christian churches which facilitates their social networking in Thailand. Sub-fellowships are formed usually based on sub-ethnicity and homophilic tendency exists in transnational networks as well. The research finds out that Chin diaspora in Thailand are committed to sending remittance but they are not keen in political participation for their home community but for some factors.

As such, the thesis concludes that Chin diaspora in Thailand meets the six features of the Safran (1991). The strength of ties is stronger within the sub-ethnic networks than their networks as a whole. The Chin diaspora in Thailand moderately contributes to the economic development of their home community and their political implication is weak. The research assesses their future aspiration and predicts that their return is less likely to happen in the near future.
B-cell activating factor as an immunological marker of disease outcome and treatment response in patients with chronic hepatitis B virus infection
Authors:   , Khlaiphuengsin Apichaya 
Published: September 2023

B-cell activating factor (BAFF), an important cytokine for B lymphocyte activation that implicated in the pathogenesis and disease progression chronic hepatitis B (CHB) patients. This study aimed at evaluating clinical correlation and prognostic role of plasma BAFF, BAFF receptor and related polymorphisms in patients with CHB undergoing pegylated interferon (peg-IFN) treatment and HBV-related hepatocellular carcinoma (HCC). This study shown that BAFF levels were elevated during treatment but decreased to pre-treatment levels after peg-IFN cessation in HBeAg-positive CHB patients. Patients with HCC had significantly higher BAFF levels compared with the non-HCC group and healthy controls. Moreover, the frequency of rs9514828 CT+TT genotypes were higher distributed in patients with chronic HBV infection compared with healthy controls. In summary, low baseline BAFF was associated with treatment response to peg-IFN and high baseline BAFF levels showed clinical correlation in terms of disease severity and overall survival in HBV-related HCC patients. These data suggest that BAFF may play an essential role in predicting a treatment response and promoting tumor development and progression.
Antilithogenic Efficacy Of An Innovative Beverage Hydrozitla: In Vitro And In Vivo Studies
Authors:   , Lordumrongkiat Nalinthip 
Published: September 2023

Urinary stone disease is a common urologic disease worldwide, and it is highly recurrent. Calcium oxalate (CaOx) stone is the most common type of urinary stones. The main causes of urinary stone formation include inadequate water intake, low urinary citrate excretion and increased oxidative stress. At the present day, potassium citrate is a drug of choice for preventing stone formation and recurrence. We developed a new regimen for preventing urinary stone formation, called HydroZitLa. It was in a form of concentrate in pouch. For consumption, water was added up to 500 mL and shake well before drink. Therefore, drinking of HydroZitLa ensured that patients gained more water intake. The active antilithogenic ingredients of HydroZitLa were citrate (16 mEq/pouch) and natural antioxidants from Thai medicinal plants. In vitro study found that HydroZitLa significantly inhibited CaOx crystal aggregation. HydroZitLa had antioxidative function to reduce oxidative stress in HK-2 cells treated with CaOx and H2O2. In vivo experiment was performed to investigate the stone inhibitory effect of HydroZitLa in nephrolithic rats was induced by ethylene glycol (EG). Twenty male Wistar rats were randomly divided into four groups; control (n=2), EG (n=6), EG+HydroZitLa (n=6) and EG+Uralyt-U (n=6). The results showed that CaOx crystal deposits in the kidneys of EG+HydroZitLa and EG+Uralyt-U groups were significantly lower than the EG group. Inflammation and oxidative stress in the kidney tissues of EG group were evidently higher than the EG+HydroZitLa and EG+Uralyt-U groups. Urinary citrate excretion in the EG+HydroZitLa and EG+Uralyt-U groups were increased compared to the EG group. In conclusion, the present study demonstrated that HydroZitLa and Uralyt-U drug exhibited the ability to inhibit CaOx crystal deposition and reduce oxidative stress in the kidneys of EG-induced nephrolithic rats. This innovative HydroZitLa product could be an effective therapeutic regimen for the treatment of urinary stone disease. The pre-clinical antilithogenic efficacy of HydroZitLa was comparable to the potassium citrate drug, Uralyt-U. Clinical efficacy of HydroZitLa will be further tested in the clinical trials.
Host and viral factors influencing disease progression and treatment response in chronic HBV infection
Authors:   , Limothai Umaporn 
Published: September 2023

Hepatitis B virus (HBV) infection represents a major risk factor of developing chronic hepatitis, cirrhosis and hepatocellular carcinoma (HCC). The clinical outcome of HBV infection depends on complex of host and virus interactions. In this study, we found that serum HBV RNA levels has emerged as a potential viral marker for active HBV infection and may be used to evaluate response to antiviral therapy and disease progression. Serum HBV RNA levels varied among different phases of chronic HBV infection (CHB). There was a correlation between serum HBV RNA levels and amount of intrahepatic covalently closed circular DNA (cccDNA), suggesting that serum HBV RNA quantification represents a useful non-invasive marker for disease monitoring in patients with CHB. In addition, the measurement of serum HBV RNA prior to pegylated interferon (PEG-IFN)-based therapy could identify patients with high probability of sustained response (SR, HBV DNA <2,000 IU/mL). Moreover, early HBV RNA kinetics identified subgroup of patients who had a minimal chance of achieving favorable outcome, which could allow response guided therapy. Host genetic factors can also affect the outcome of HBV infection. We investigated the influence of single nucleotide polymorphisms (SNPs) in vitamin D-related genes including 25-Hydroxyvitamin D-1 alpha-hydroxylase (CYP27B1), vitamin D binding protein (DBP) and vitamin D receptor (VDR) and genetic variation in signal transducer and activator of transcription 4 (STAT4) on HBV infection outcomes. The results of this study showed that variations of both rs4646536 in the CYP27B1 gene and rs7574865 in the STAT4 gene might contribute to increased susceptibility to HBV-related HCC in the Thai population but did not correlate with HBV susceptibility and HBV natural clearance. In addition, both SNPs were predictive factors of response to PEG-IFN therapy in Thai patients with CHB. Thus, the determination of these SNPs could maximize cost-effectiveness of PEG-IFN in patients with CHB.
The difference patterns of electrophysiological properties and effects of kynurenic acid in trigeminal ganglion neurons isolated from rats migraine models
Authors:   , Haji-a-sa Naeemah 
Published: September 2023

Migraine headache generates in trigeminal nociceptive system which is activated by cortical spreading depression (CSD) phenomenon. There are also some neurotransmitter changes relating to pathogenesis of migraine, one of representative examples is serotonin (5-HT) depletion that may predispose to migraine development. Trigeminal ganglion (TG) is a structure containing cell body of neurons that undertakes a role as first order neuron in trigeminal nociceptive system. Moreover, the alteration of glutamate may contribute to hyperactivity of its specific receptors, for instance N-methyl-D-aspartate (NMDA) receptor. Endogenous biomolecule, such as kynurenic acid (KYNA) which is derived form of 5-HT can inhibit NMDA receptor. Basically, KYNA plays a role as NMDA antagonist, and at the same time, it is one of metabolites of tryptophan pathways as well as 5-HT. This study aimed to explore the electrophysiological properties change of TG neuron isolated from rat migraine models (CSD and 5-HT depletion), and the effects of KYNA on them. The results revealed that resting membrane potential (RMP) of TG neurons had significant depolarization shift in CSD and combined model of CSD and 5-HT depletion, while this alteration was not observed in 5-HT depletion only. In conclusion, CSD is a cortical model of migraine that affects to TG neuron. Thus, CSD has a potential to alter RMP of TG neurons that may results to increase of neuronal excitability in trigeminal nociceptive system.
Anticancer activity of plumbagin on stem-like characteristics, tumor angiogenesis and metastatic potential in endocrine resistant breast cancer
Authors:   , Sakunrangsit Nithidol 
Published: September 2023

Plumbagin (PLB), a naphthoquinone compound and vitamin K3 derivative, was shown its potent cytotoxicity and anti-invasion in anti-hormonal resistant cells through the inhibition of Snail-induced epithelial mesenchymal transition (EMT). Overexpression of Snail leads to decrease E-cadherin and increase of beta-catenin, resulting in the activation of Wnt pathway that increases cancer stem-like characteristics in these resistant cells. This study was aimed to investigate the inhibitory effects of PLB on cancer stem-like cells (CSLCs), angiogenesis and Wnt signaling-mediated cell proliferation and invasion. In addition, our study also focused on the anticancer activity of PLB in anti-hormonal resistant breast cancer in vivo. Both anti-hormonal resistant LCC2 and LCC9 cells increased beta-catenin and dysregulated Wnt signaling. Thus, these two cell lines were able to form mammospheres with elevated stem cell markers. This property is the characteristic of CSLCs. Our study showed that PLB significantly diminished the colony and mammosphere formation in a concentration-dependent manner. PLB also dramatically reduced angiogenic factors, stem cell markers and p-Akt expression. Our findings demonstrated the anti-proliferative and anti-invasive properties of PLB were partly mediated by Wnt signaling. Importantly, the inhibitory effects of PLB in cell lines were consistent with the result in xenograft mice. PLB at the doses of 2 mg/kg/day and 4 mg/kg/day significantly inhibited tumor growth without any adverse effects on body weight and blood coagulation. Moreover, PLB treatment not only repressed tumor angiogenesis, but also inhibited lung metastasis. Overall, these findings supported the role of PLB as an anti-cancer agent for anti-hormonal resistant breast cancer.
Does Early Initiation of Renal Replacement Therapy Have an Impact on 28-day mortality in Critically Ill Patients with Acute Kidney Injury with Positive Furosemide Stress Test?: a Multicenter Randomized Controlled Trial
Authors:   , Lumlertgul Nuttha 
Published: September 2023

Background: The timing of initiation of renal replacement therapy (RRT) in severe acute kidney injury (AKI) remains controversial, with early initiation resulting in unnecessary therapy for some patients while expectant therapy may delay RRT for other patients. The furosemide stress test (FST) has been shown to predict the need for RRT and therefore could be used to exclude low-risk patients from enrollment in trials of RRT timing. Methods: FST was performed using intravenous furosemide (1 mg/kg in furosemide-naive patients or 1.5 mg/kg in previous furosemide users). FST-nonresponsive patients (urine output less than 200 mL in 2 h) were then randomized to early (initiation within 6 h) or standard (initiation by urgent indication) RRT. The primary outcome is 28-day difference in mortality rates between early and standard RRT. Results: FST was completed in 162 patients. Only 6/44 (13.6%) FST-responsive patients ultimately received RRT. Among 118 FST-nonresponsive patients, 98.3% in the early RRT arm and 75% in the standard RRT arm received RRT. We observed no differences in 28-day mortality (62.1 versus 58.3%, p = 0.68), 7-day fluid balance, or RRT dependence at day 28. Conclusion: The furosemide stress test appears to be feasible and effective in identifying patients for randomization to different RRT initiation times. There was no difference between 28-day mortality rates between furosemide-nonresponsive patients who were randomized to early or standard RRT initiation.
Comparison of the implant deviation between implants placed using static and dynamic computer assisted surgery methods
Authors:   , Kaewsiri Dechawat 
Published: September 2023

Objectives: The aim of this study was to compare the accuracy of implant placement in terms of deviations related to the virtual plan between static and dynamic computer assisted implant surgery (CAIS) systems in single tooth space.

Materials & Methods: 60 single implants were randomly placed using two difference CAIS systems by one surgeon. Preoperative CBCT transferred to implant planning software were used to plan the virtual implant position. Implants were placed using either stereolithographic guide template for static CAIS group (n = 30) or implant navigation system for dynamic CAIS group (n = 30). Postoperative CBCT were taken to acquire the implant position and were imported to implant planning software in order to perform the implant deviation analysis. Primary outcomes were the deviations at implant platform, implant apex, and angular deviation.

Results: The mean deviations at implant platform and implant apex in static CAIS group were 0.97 ± 0.44 mm and 1.28 ± 0.46 mm respectively, while in dynamic CAIS group were 1.05 ± 0.44 mm and 1.29 ± 0.50 mm respectively. The angular deviation in static and dynamic CAIS group were 2.84 ± 1.71 degrees and 3.06 ± 1.37 degrees respectively. No significant differences between both groups was found.

Conclusions: Dynamic CAIS system provides the accuracy of implant placement in single tooth space similar to static CAIS system.