bluuebunny/crossref_metadata_2025_split huggingface dataset:
Carotid baroreceptor stimulation prevents oxidative stress by inhibiting MAO‐A and prevents cardiac remodeling in obese rats
Authors: Wu Yuan , Yu Qiao , Dai Mingyan , Wang Jing , Shu Ling , Dai Dilin , Chen Jie , Zhang Junxia , Bao Mingwei 
Published: March 2023

AbstractObjectiveSympathetic nervous system overactivation and abnormal lipid metabolism are featured in obesity and may lead to cardiac remodeling. The effects of carotid baroreceptor stimulation (CBS) on cardiac remodeling in obese rats and the underlying mechanisms were explored.MethodsAn obesity model was induced by 16‐week high‐fat diet feeding. A CBS device was implanted at the 8th week. Body weight and blood pressure measurements, electrocardiography, echocardiography, and glucose and insulin tolerance tests were conducted before sampling. Plasma analysis and histological and biological analyses of left ventricle were also performed. Neonatal rat cardiomyocytes cocultured with 3T3‐L1 in transwell chambers were used to investigate the mechanisms.ResultsCBS alleviated several manifestations of obesity, including increased body weight, high blood pressure, hyperlipidemia, and enhanced sympathetic activity. In obese hearts, norepinephrine levels decreased, and the monoamine oxidase A (MAO‐A) and reactive oxygen species level increased; these changes, as well as cardiac fibrosis, lipid metabolic disorders, and heart dysfunction, were inhibited by CBS. Neonatal rat cardiomyocytes incubated with norepinephrine showed MAO‐A upregulation, increased reactive oxygen species levels, lipid metabolic disorders, and inflammatory response, which were inhibited by clorgyline, a selective MAO‐A inhibitor.ConclusionsCBS effectively suppresses sympathetic nervous system activity and oxidative stress mediated by MAO‐A and prevents cardiac remodeling in obese rats.image
Effect of partially reduced fullerenol‐graphene hybrid nanofiller on photophysical and super capacitance properties of fluorescence conducting polymer nanocomposites
Authors: Jaiswal Rimpa , Saha Uttam , Goswami Thako Hari , Maji Pradip K. 
Published: March 2023

AbstractThe effect of partially reduced fullerenol‐graphene oxide (rFGO) nanofiller on photophysical and super capacitance properties of binary nanocomposites containing phenylene‐alt‐thiophene fluorescence conducting polymer (FCP) were investigated. Nanocomposites were prepared by solution mixing, which allows uniform nanofiller distribution into the polymer matrix. Microscopic analyses of nanocomposites display homogeneous dispersion of nanofiller into the polymer matrix. Quenching of photoluminescence reveals the photosensitized electron transfer from light‐absorbing FCP (acting as an electron donor) to fullerenol‐graphene nanofiller (acting as an electron acceptor). The presence of partially reduced graphene sheets in rFGO nanofiller facilitates the photosensitized electron transfer along the surface and also through the interlayer channels of graphene sheets due to the pillar effect of fullerenol. UV–vis and photoluminescence spectroscopic characterization data reveal excellent interaction between filler and matrix, responsible for electron transfer mechanism. Super capacitance properties of binary nanocomposites in three different electrolytes (acid, neutral and alkaline) were also investigated and the best galvanic charge discharge result of 173 F/g at 2 A/g current density was obtained at 2 wt% loading up to 500th cycle for rFGO in acid electrolyte only. The material was ineffective in the alkaline electrolyte and showed poor results in neutral electrolyte. An attempt has been made to evaluate the structure–property relationship of nanocomposites from their thermal, photophysical, and electrochemical properties.
Impact of piflufolastat F‐18 PSMA PET imaging on clinical decision‐making in prostate cancer across disease states: A retrospective review
Authors: Arafa Ali T. , Jain Aditya , Skrobanek Pavel , Humphrey Brad , Froelich Jerry W. , Antonarakis Emmanuel S. 
Published: March 2023

AbstractIntroductionPiflufolastat F‐18 (18F‐DCFPyL) prostate‐specific membrane antigen (PSMA) positron emission tomography (PET) imaging is approved by the US food and drug administration for initial staging of high‐risk prostate cancer, biochemical recurrence (BCR), and restaging of metastatic prostate cancer. Here, we sought to assess how its integration into clinical care may have impacted the management of patients.MethodsWe identified 235 consecutive patients who underwent an 18F‐DCFPyL PET scan from August 2021 to June 2022. The median prostate‐specific antigen at the time of imaging was 1.8 ng/mL (Range: 0−3740 ng/mL). Descriptive statistics were used to analyze its impact on clinical care for a subset of 157 patients with available treatment information: 22 for initial staging, 109 with BCR, and 26 patients with known metastatic disease.ResultsPSMA‐avid lesions were detected in 154/235 (65.5% of) patients. In patients undergoing initial staging, 18/39 (46.2% of) patients had extra‐prostatic metastatic lesions; 15/39 (38.5% of) scans were negative and 6/39 (15.4%) had equivocal results. 12/22 (54.5% of) patients had a change in their treatment plan post‐PSMA PET scan while 10/22 (45.5%) had no change in their treatment plan. In the BCR cohort, 93/150 (62.0%) had a local recurrence or metastatic lesions. Equivocal and negative scans accounted for 11/150 (7.3%) and 46/150 (30.7%) of scans, respectively. 37/109 (33.9% of) patients had a change in their treatment plan, while treatment was not altered in 72/109 (66.1% of) cases. In patients with metastatic disease, 43/46 (93.5%) had PSMA‐avid lesions identified; equivocal and negative scans accounted for 2/46 (4.3%) and 1/46 (2.2%) of scan results, respectively. 6/26 (23.1%) had their tentative treatment plan adjusted after the PSMA PET scan. No change in the treatment plan was observed in 20/26 (76.9% of) cases.ConclusionIntegration of F‐18 PSMA PET imaging impacted clinical decision‐making and subsequent management across all stages of prostate cancer. It remains to be seen whether this translates into superior survival outcomes.
Small business administration loans, economic development, and state‐level employment
Authors: Orzechowski Paul E. 
Published: March 2023

AbstractThis study analyzes the relationship between the US Small Business Administration (SBA) loan programs and state‐level employment by utilizing a dynamic first‐difference generalized method of moments fixed effects statistical approach using annual data from 1996 to 2013. The US state‐level panel data show a positive relationship between growth rates in SBA lending per capita and states' civilian employment levels. This relationship appears to be stronger in states with below‐average incomes than in states with higher incomes. This study contributes to the understanding of how SBA lending programs can best help foster state‐level economic development and employment.
Effect of prior immunisation with smallpox vaccine for protection against human Mpox: A systematic review
Authors: Akter Fahima , Hasan Tahira Binte , Alam Farhana , Das Aurpy , Afrin Shanta , Maisha Sadia , Masud Abdullah Al , KM Saif‐Ur‐Rahman 
Published: March 2023

AbstractMonkeypox is an emerging threat to humans since a new outbreak in May 2022. It is hypothesised that increasing the immunologically naive population after the cessation of the smallpox vaccination campaign in the 1980s is one of the leading causes of it. A literature search was conducted using different electronic databases including MEDLINE (through PubMed), SCOPUS, Web of Science, Cochrane library, and EMBASE for relevant studies. After duplication removal, abstract and title screening, and full‐text screening were done, the data were extracted, tabulated, and analysed. The risk of bias was assessed following the Risk of Bias Assessment tool for Non‐randomised Studies. We found a total of 1068 relevant articles and finally, we included 6 articles including 2083 participants. The studies suggested that smallpox is 80.7% efficacious to prevent human monkeypox and the immunity provided by prior smallpox vaccination is long‐lasting. Moreover, the smallpox vaccination decreases the risk of human monkeypox by 5.2‐folds. Two cross‐sectional studies based on the Democratic Republic of the Congo (DRC) including a total of around 1800 monkeypox cases found that unvaccinated participants had 2.73 and 9.64‐fold increased risk of monkeypox compared to the vaccinated participants. Other studies in USA and Spain also demonstrated that unvaccinated people were more prone to develop monkeypox than vaccinated people. Furthermore, monkeypox incidence has increased by 20 folds, 30 years after the cessation of the smallpox vaccination campaign in DRC. Evidence‐based preventive and therapeutic agents are still not available for human monkeypox. Further study should be done to explore the role of the smallpox vaccine in preventing human monkeypox.
Introduction
Authors: García-Sancho Miguel , Lowe James 
Published: March 2023

AbstractThis introductory chapter outlines the technical and conceptual basics of genomics, its history and current impact. We use the metaphor of the history of genomics as an hourglass to challenge the widespread association of genomics with the idea of a single, international and successful ‘Human Genome Project’. We query this hourglass depiction by examining genomics research in both human and non-human organisms: yeast and pig, as well as Homo sapiens. We also introduce a concept that helps differentiate genomics across our three chosen species: communities of genomicists. The objectives, research necessities and visions of these communities are profoundly entangled with the genomes of the organisms they work on. This materialises in different models of organising and conducting genomics and affects the affordances and limitations of the resulting reference genomes.
Distributed and Concentrated Strategies in the Sequencing of the Yeast Genome
Authors: García-Sancho Miguel , Lowe James 
Published: March 2023

AbstractThis chapter examines the sequencing of yeast (Saccharomyces cerevisiae), which was conducted by an international collaboration that released its reference genome in 1996. The European side of this collaboration exhibited a distributed model of sequencing, in which yeast biology laboratories made immediate research use of the sequence data they produced. In the USA, by contrast, large-scale sequencing centres were established, with yeast genomics constituting a pilot for the eventual sequencing of the human genome. The European effort involved a heterogenous community of yeast ‘genomicists’ and constituted a distinct model of genomics not subordinated to the whole-genome sequencing ofHomo sapiens. Most of the human genome projects that proliferated in the early to mid-1990s instantiated some form of this distributed model, which co-existed with the more concentrated and intensive production of the human reference genome.
Theoretischer Zugang und Forschungsstand zu Stress, Belastung und subjektivem Wohlbefinden
Authors: Maly-Motta Hanna 
Published: March 2023

ZusammenfassungWann sprechen wir von Wohlbefinden, wie entsteht Stress und wie hängen Stress, Belastung und das Konzept des Wohlbefindens zusammen? Mit Hilfe unterschiedlicher theoretischer Modelle und Ideen, legt dieses Kapitel in einem ersten Schritt die Grundlage für das theoretische Verständnis dieser zentralen Begriffe. Deutlich wird dabei, dass Stress das Individuum selbst, aber auch die es direkt umgebenden sozialen Beziehungen (z. B. die Eltern-Kind-Beziehung, Paarbeziehung) betreffen kann. In einem zweiten Schritt befasst sich das Kapitel daher mit theoretischen und empirischen Arbeiten, die der Frage nachgehen was in Familien aber auch Paarbeziehungen unter Stress passiert. Da sich der Fokus von einem stärker individuum- zu einem familienzentrierten Stressverständnis verschiebt, werden die theoretischen und empirischen Erkenntnisse zu Familien-, Paar- und Elternstress explizit hinsichtlich der bidirektionalen Verknüpfung elterlicher Belastung und kindlicher Anforderungen aufgearbeitet.
Teilstudie II: Schatz, das Baby schreit! Das Wohlbefinden von Eltern am Übergang zur Elternschaft
Authors: Maly-Motta Hanna 
Published: March 2023

ZusammenfassungDie Geburt des ersten Kindes ist eine turbulente Phase in der Familienentwicklung und stellt nicht nur Mütter und Väter vor individuelle Herausforderungen, sondern auch die Paarbeziehung. Immer wieder auftretende kognitive und motorische Entwicklungsschübe des Kindes, in denen sich vorübergehende Schlaf- oder Fütterprobleme und allgemein kindliche Anforderungen krisenhaft zuspitzen können, zähren dabei an den Nerven. Anforderungen des Kindes spielen in dieser vulnerablen Phase daher eine besondere Rolle um das individuelle Belastungs- und Stresserleben von Müttern und Vätern, aber auch Unstimmigkeiten innerhalb der Paarbeziehung besser verstehen zu können. Die vorliegende Teilstudie liefert daher, im Gegensatz zu bisherigen Forschungsbefunden, einen differenzierteren Einblick in die Rolle des Kindes für Anpassungsanforderungen innerhalb der Paarbeziehung sowie für das individuelle Wohlbefinden der Eltern. Im Fokus stehen zugleich vermittelnde Mechanismen, die zwischen den Anforderungen des Kindes und dem individuellen sowie partnerschaftsrelevanten Wohlbefinden stehen können. Die Datengrundlage für die empirische Untersuchung bildet das Beziehungs- und Familienpanel (pairfam). Die Ergebnisse bestätigen, dass erhöhte kindliche Anforderungen und, im Falle der Partnerschaftsqualität, ein größeres Ausmaß erlebter ängstlicher Überfürsorge dem Baby gegenüber, am Übergang zur Elternschaft, eine zentrale Rolle für unterschiedliche Dimensionen elterlichen Wohlbefindens spielen. Machten sich befragte Eltern beispielsweise viele Sorgen darüber, ob sie mit dem Baby alles richtig machen, übertrug sich dies über eine konfliktreichere Kommunikation des Paares negativ auf die Partnerschaftsqualität.
Abschließende Diskussion
Authors: Maly-Motta Hanna 
Published: March 2023

ZusammenfassungWas brauchen Eltern, damit Elternschaft gelingt und positiv mit dem elterlichen Wohlbefinden verknüpft ist und welche Akteure können helfen, den Weg dafür zu ebnen? Das letzte Kapitel diskutiert die gewonnenen Ergebnisse abschließend vor einer sozialpolitischen sowie (sozial-)pädagogischen Betrachtungsdimension. Es können zentrale Schlüsse, die sozialstaatliche Leistungen aber auch Beratungs- und Hilfsangebote für Familien betreffen, abgeleitet werden. Die Ergebnisse der Arbeit sind damit für Eltern selbst, politische Entscheidungsträger sowie für die praktische Arbeit in (sozial-)pädagogischen Berufsfeldern von Bedeutung.
Developmental stage and lower quadriceps flexibilities and decreased gastrocnemius flexibilities are predictive risk factors for developing Osgood–Schlatter disease in adolescent male soccer players
Authors: Takei Seira , Torii Suguru , Taketomi Shuji , Iizuka Satoshi , Tojima Michio , Iwanuma Soichiro , Iida Yukako , Tanaka Sakae 
Published: March 2023

Abstract
Purpose
This study aimed to elucidate the influential predictive risk factors of Osgood–Schlatter disease (OSD) on the support (non-kicking) leg among adolescent soccer players considering peak height velocity (PHV) age and investigate the cut-off values of the predictive variables.

Methods
A cohort of 302 Japanese adolescent male soccer players aged 12–13 years were followed over 6 months. All players underwent physical examination, tibial tubercle ultrasonography, anthropometric and whole-body composition measurements, and muscle flexibility test of the support leg at the baseline. The developmental stage was evaluated from the PHV age. The OSD of the support leg was diagnosed 6 months later; players were divided into the OSD and control (CON) groups. The predictive risk factors were analyzed by multivariate logistic regression analysis.

Results
There were 42 players who had developed OSD at baseline and they were excluded from the study. Among the 209 players, 43 and 166 belonged to the OSD and CON groups, respectively. The predictive risk factors of OSD development were PHV age ± 6 months at baseline (p = 0.046), apophyseal stage of tibial tuberosity maturity at baseline (p < 0.001), quadriceps flexibility ≥ 35° at baseline (p = 0.017), and decrease in gastrocnemius flexibility in 6 months (p = 0.009).

Conclusion
PHV age ± 6 months at baseline, apophyseal stage of the tibial tuberosity at baseline, quadriceps flexibility ≥ 35° at baseline, and decrease in gastrocnemius flexibility in 6 months are predictive risk factors of OSD development in the support leg among adolescent male soccer players. It is crucial to know the PHV age of each player, and not only the flexibility of quadriceps muscle but also the gastrocnemius should be monitored to predict OSD.

Level of evidence
II.
Current State of Robotics in Interventional Radiology
Authors: Najafi Ghazal , Kreiser Kornelia , Abdelaziz Mohamed E. M. K. , Hamady Mohamad S. 
Published: March 2023

AbstractAs a relatively new specialty with a minimally invasive nature, the field of interventional radiology is rapidly growing. Although the application of robotic systems in this field shows great promise, such as with increased precision, accuracy, and safety, as well as reduced radiation dose and potential for teleoperated procedures, the progression of these technologies has been slow. This is partly due to the complex equipment with complicated setup procedures, the disruption to theatre flow, the high costs, as well as some device limitations, such as lack of haptic feedback. To further assess these robotic technologies, more evidence of their performance and cost-effectiveness is needed before their widespread adoption within the field. In this review, we summarise the current progress of robotic systems that have been investigated for use in vascular and non-vascular interventions.
Dynamic myocardial CT perfusion imaging—state of the art
Authors: Sliwicka Olga , Sechopoulos Ioannis , Baggiano Andrea , Pontone Gianluca , Nijveldt Robin , Habets Jesse 
Published: March 2023

Abstract
In patients with suspected coronary artery disease (CAD), dynamic myocardial computed tomography perfusion (CTP) imaging combined with coronary CT angiography (CTA) has become a comprehensive diagnostic examination technique resulting in both anatomical and quantitative functional information on myocardial blood flow, and the presence and grading of stenosis. Recently, CTP imaging has been proven to have good diagnostic accuracy for detecting myocardial ischemia, comparable to stress magnetic resonance imaging and positron emission tomography perfusion, while being superior to single photon emission computed tomography. Dynamic CTP accompanied by coronary CTA can serve as a gatekeeper for invasive workup, as it reduces unnecessary diagnostic invasive coronary angiography. Dynamic CTP also has good prognostic value for the prediction of major adverse cardiovascular events. In this article, we will provide an overview of dynamic CTP, including the basics of coronary blood flow physiology, applications and technical aspects including protocols, image acquisition and reconstruction, future perspectives, and scientific challenges.

Key Points
• Stress dynamic myocardial CT perfusion combined with coronary CTA is a comprehensive diagnostic examination technique resulting in both anatomical and quantitative functional information.
• Dynamic CTP imaging has good diagnostic accuracy for detecting myocardial ischemia comparable to stress MRI and PET perfusion.
• Dynamic CTP accompanied by coronary CTA may serve as a gatekeeper for invasive workup and can guide treatment in obstructive coronary artery disease.
Indigenous approaches to perinatal mental health: a systematic review with critical interpretive synthesis
Authors: Meredith Cara , McKerchar Christina , Lacey Cameron 
Published: March 2023

AbstractIndigenous mothers and birthing parents experience significant inequities during the perinatal period, with mental health distress causing adverse outcomes for mothers/birthing parents and their infants. Limited literature is available to inform our understanding of solutions to these issues, with research primarily focusing on inequities. Our aim was to conduct a systematic review of Indigenous approaches to treatment of perinatal mental health illness. Following the PRISMA guidelines for systematic literature reviews, an electronic search of CINAHL, Medline, PubMed, Embase, APA PsycInfo, OVID Nursing, Scopus, Web of Science, and Google Scholar databases was conducted in January and February 2022 and repeated in June 2022. Twenty-seven studies were included in the final review. A critical interpretive synthesis informed our approach to the systematic review. The work of (Yamane and Helm J Prev 43:167–190, 2022) was drawn upon to differentiate studies and place within a cultural continuum framework. Across the 27 studies, the majority of participants were healthcare workers and other staff. Mothers, birthing parents, and their families were represented in small numbers. Outcomes of interest included a reduction in symptoms, a reduction in high-risk behaviours, and parental engagement/attachment of mothers/birthing parents with their babies. Interventions infrequently reported significant reductions in mental health symptoms, and many included studies focused on qualitative assessments of intervention acceptability or utility. Many studies focused on describing approaches to perinatal mental health distress or considered the perspectives and priorities of families and healthcare workers. More research and evaluation of Indigenous interventions for perinatal mental health illness is required. Future research should be designed to privilege the voices, perspectives, and experiences of Indigenous mothers, birthing parents, and their families. Researchers should ensure that any future studies should arise from the priorities of the Indigenous population being studied and be Indigenous-led and designed.
Cerebral abscesses with odontogenic origin: a population-based cohort study
Authors: Jespersen Frederik V. B. , Hansen Signe U.-B. , Jensen Simon S. , Omland Lars H. , Helweg-Larsen Jannik , Bjarnsholt Thomas , Nielsen Claus H. , Ziebell Morten , Bodilsen Jacob , Markvart Merete 
Published: March 2023

Abstract
Objectives
Recent studies have indicated that cerebral abscess (CA) patients with odontogenic origin are on the rise. However, CA patients are often poorly characterized and with an unknown etiologic background. The purpose of this study is to identify and characterize CA patients that may have an odontogenic origin based on microbiologic, radiographic, and/or clinical findings.

Materials and methods
This is a population-based cohort study analyzing retrospective and prospective data from CA patients. Radiographic examinations of panoramic radiographs (PRs) or computed tomography (CT) scans were conducted. CA patients characterized with odontogenic origin required the fulfilment of the following criteria on admission: (1) Oral pathologic conditions were the only bacterial infections present, (2) oral microorganisms were isolated in the purulent exudate from the brain, and (3) radiographically and/or clinical recordings of oral pathologic conditions.

Results
A total of 44 patients could be included in this study of which 25 (57%) were characterized as having CA with a likely odontogenic origin. Type two diabetes (T2D) (p = 0.014) and microorganisms of the Streptococcus anginosus group (SAG) (p < 0.01) were overrepresented in patients with CAs of odontogenic origin.

Conclusions
Odontogenic infections may cause CAs to a greater extent than previously assumed. T2D was overrepresented among patients with odontogenic CA. When microorganisms of the SAG were isolated from the brain pus, CA patients had a predisposing odontogenic or sinus infection.

Clinical relevance
The identification of patients with a likely odontogenic CA will contribute to understanding the etiology of the infectious disease and highlighting the importance of preserving oral health.