bluuebunny/crossref_metadata_2025_split huggingface dataset:
Epidemiology, literacy, risk factors, and clinical status of oral cancer in East Africa: A scoping review
Authors: Aminu Kafayat , Aladelusi Timothy Olukunle , Adisa Akinyele Olumuyiwa , Ezeagu Chiamaka Norah , Salami Afeez Abolarinwa , Nwafor Jacob Njideka , Uwambaye Peace , Amzat Jimoh , Murererehe Julienne , Omoleke Semeeh Akinwale , Abdulaziz Mohammed , Jayasinghe Ruwan Duminda , Kanmodi Kehinde Kazeem 
Published: February 2025

Background
Oral cancer (OC) is a topical public health issue in East Africa due to increasing incidence of the disease. Public health efforts to address the oral cancer burden depends largely on the available empirical evidence. Hence, this scoping review aims to map the existing empirical evidence on oral cancer in East African countries.

Methods
The Preferred Reporting Items for Systematic Review and Meta-analysis Extension for Scoping Reviews (PRISMA-ScR) was used as a guideline for reporting this scoping review. Additionally, we ensured quality assessment of the methodology and reporting process of this study using the AMSTAR 2 checklist. We conducted a systematic search of nine research databases on 17th November 2023, and reviewed studies published in English from year 2000 to 17th November 2023. The team developed data extraction form and data extraction was done by two reviewers. Thematic analyses were conducted manually and presented in texts, tables and flow chart.

Results
Only 30 full manuscripts were included in this review. Twenty-nine out of 30 studies were either hospital- or clinic-based while two were community-based. Only four studies showed gaps and obvious disparities in awareness and knowledge levels across East Africa, however, higher levels of awareness were reported among dentists and dental patients relative to the general population. Most neoplasms were presented and diagnosed late. The review finding also highlighted the significant impact of Toombak use on the oral microbiome composition, potentially contributing to oral cancer risks. Further, this review elucidated the prognostic relevance of PD-L1 expression at the invasive tumor front and microbial composition, with Candida correlating with adverse prognosis and Malassezia showing associations with improved survival rates. Also, Toombak usage, tumor staging, and mucosal field alterations emerged as predictors of local recurrence, while lymph node involvement and extranodal extension were associated with regional recurrence among Sudanese cohorts. Finally, a few studies undertook an evaluation of instrument validity for OC detection, revealing promising outcomes concerning diagnostic accuracy and instrument reliability.

Conclusions
There is a dire need for targeted interventions and early detection strategies tailored to the unique epidemiological and clinical profiles of oral and maxillofacial tumors in East Africa. Public health interventions aimed at curbing the prevalence of Toombak use and promoting healthier lifestyle choices to reduce the oral diseases incidence in Sudan and other regions where these behaviors are prevalent remain germane.
Serum insulin-like growth factor 1 and the prognosis of patients with advanced liver diseases: a meta-analysis
Authors: Liu Yihan , Xue Haojie , Liu Yang , Li Han , Liang Qian , Ma Longhui , Zhao Ming , Liu Junying 
Published: February 2025

Introduction:
Serum insulin-like growth factor 1 (IGF-1), a hepatocyte-derived cytokine, has been suggested to reflect hepatic function reserve. The aim of this systematic review and meta-analysis was to investigate the association between serum IGF-1 levels upon the admission and prognosis of patients with advanced liver diseases.

Methods:
A thorough examination of the literature was conducted across various databases, namely PubMed, Embase, Web of Science, Wanfang, and CNKI, with the aim of identifying relevant cohort studies. The data were synthesized using the random-effects model, taking into account the potential impact of heterogeneity.

Results:
A total of nine cohorts were included. Patients with a low serum level of IGF-1, as compared to those with a high IGF-1 at baseline, exhibited a significantly poorer transplant-free survival (risk ratio [RR]: 3.03, 95% confidence interval: 2.17 to 4.22, p < 0.001), with no significant heterogeneity observed (p for Cochrane Q test = 0.92, I2 = 0%). A sensitivity analysis, which was conducted by excluding one study at a time, yielded consistent results (RR: 2.94 to 3.24, p all < 0.05). Additionally, consistent results were observed in further subgroup analyses based on various factors, including cutoffs of IGF-1, country of the study, patient diagnosis, methods for measuring serum IGF-1, follow-up duration, analytic model, and quality scores (p for subgroup difference all > 0.05).

Conclusions:
A diminished serum IGF-1 level upon admission could potentially serve as an indicator for an unfavorable prognosis among patients afflicted with advanced liver disease, such as severe hepatitis and cirrhosis.
The Significance of Oxidized Low-Density Lipoproteins and Receptors LOX-1 in Type 2 Diabetes Mellitus
Authors: Fetlam D. L. , Chumachenko A. G. , Pisarev V. M. 
Published: February 2025

INTRODUCTION. Type 2 diabetes mellitus (T2DM) occurs in 8.5% of the adult population with a tendency to increase. A characteristic feature of T2DM is dyslipidemia. One of its manifestations includes accumulation of increased concentration of oxidized low-density lipoproteins (ox-LDL) in circulation. Ox-LDL molecules act on cells through LOX-1 receptors.THE PURPOSE OF THE REVIEW is to demonstrate results of studies presented in publications of 2010–2024 (PubMed, RSCI) indicating the pathogenetic role of ox-LDL and its LOX-1 receptors in T2DM development and course.MATERIALS AND METHODS. In the analysis of more than 2800 literature sources (PubMed), in which together with term “­diabetes mellitus” keywords are found: ox-LDL (1150 sources) or LOX-1 (159 sources), as well as OLR1 (106 sources), 50 sources were identified that are directly related to T2DM and the studied functionally related markers — the LOX-1 receptor and its ligand ox-LDL.RESULTS. LOX-1 is scavenger receptor that uses ox-LDL as its proper ligand. Gene OLR1 encodes ox-LDL receptor, LOX-1. The linking of T2DM and circulating levels of ox-LDL is bidirectional. The emerging insulin resistance directly correlates with oxidation of low-density lipoproteins, which is observed in more than 80% of patients and depends on the duration of T2DM. High plasma ligand levels are associated with increased type 2 diabetes risk. The mechanism of this association is thought to be related to functionally significant expression of LOX-1 on pancreatic cells. It was shown that pancreatic β-cells in the presence of ox-LDL increased production of the inducible early repressor of the cAMP signaling pathway, ICER. As result of ICER action, insulin production and secretion ceased. Increased ox-LDL concentrations are a pathogenetically significant factor in the development of atherosclerotic vascular lesions, as they stimulate the generation of foam cells. Ox-LDL-LOX-1-mediated interactions on the vascular surface led to endothelial dysfunction with subsequent development of tissue hypoperfusion and organ dysfunction.CONCLUSION. Circulating ox-LDL, in interaction with its receptor LOX-1, makes a significant contribution to the development of T2DM, promoting its progression. Increased concentration of ox-LDL in blood increases the risk of severe T2DM, leading to endothelial dysfunction and promoting the development of atherosclerotic vascular lesions.
Overweight and obesity in patients with type 1 diabetes: associations with vascular complications and biomarkers of vascular remodeling
Authors: Klimontov V. V. , Yushin A. Yu. , Semenova Yu. F. , Korbut A. I. , Romanov V. V. 
Published: February 2025

BACKGROUND: The prevalence of overweight and obesity in patients with type 1 diabetes (T1D) is increasing, which raises the issue of their impact on the development of complications.AIM: to study the associations of overweight and obesity with vascular complications, cardiovascular risk factors and serum levels of vascular remodeling biomarkers in patients with T1D.MATERIALS AND METHODS: The study included 547 patients, including 309 with body mass index (BMI) <25 kg/m2, 155 with BMI 25–29.9 kg/m2, and 83 with BMI ≥30 kg/m2. Insulin sensitivity was assessed by the estimated glucose disposal rate. In the serum of 130 patients and 30 individuals with normal weight and normal glucose tolerance, concentrations of advanced glycation end products (AGEs), endothelin-1, endothelial NO synthase (NOS3), adrenomedullin (ADM), endothelial cell-specific molecule-1 (ESM1), cell adhesion molecules (ICAM-1 and VCAM-1), integrin-associated protein-1 (IAP-1), integrin receptor subunit (ITGB1), heme oxygenase-1 (HO-1), GAS6, decorin, and transforming growth factor β1 (TGF-β1) were determined by ELISA.RESULTS: Obesity in patients with T1D was independently associated with coronary artery disease, myocardial infarction, and chronic heart failure. Overweight was an independent predictor of chronic heart failure only. Patients with BMI ≥25 kg/m2, when compared with those with BMI <25 kg/m2, were older, had a reduced insulin sensitivity and increased levels of triglycerides, LDL-cholesterol, uric acid, and high-sensitivity C-reactive protein. Patients with T1D, as compared with controls, showed a significant increase in serum AGEs, endothelin-1, ICAM-1, VCAM-1, IAP-1, ESM1, HO-1, GAS6, and TGF-β1. Overweight patients, when compared with those with BMI <25 kg/m2, demonstrated higher levels of ICAM-1, IAP-1, ITGB1 and TGF-β1, while obese individuals had increased concentrations of AGEs, IAP-1 and HO-1.CONCLUSION: In patients with T1D, overweight and obesity are associated with vascular complications, their risk factors and biomarkers of vascular remodeling.
Framing AI in higher education: a critical discourse analysis of inclusivity and power in university AI guidance documents
Authors: Simpson Nicholas Hugh 
Published: February 2025

Abstract
The language of artificial intelligence (AI) guidance documents in higher education (HE) institutions reflects broader societal dynamics and raises important questions about inclusivity and accessibility. This study investigates how selective (Russell Group) and less selective UK universities craft their student-facing AI guidance documentation, focusing on the language and discourses embedded within these documents. Using critical discourse analysis (CDA), documents from six UK universities (three less selective institutions from the top of the intergenerational mobility rankings and three highly selective universities from the bottom) are analysed to explore differences in language, style, content, and framing of agency and responsibility. Findings reveal that selective universities often adopt hierarchical, authoritarian language that emphasises individual student accountability for the proper use of AI tools. Such an approach reflects selective universities’ institutional approaches to power and hierarchy and aligns with broader societal worries about the influence of AI. In contrast, less selective institutions adopt a relatively more inclusive and explanatory rhetoric more consistent with the expectations and needs of students from diverse socioeconomic backgrounds.
Age and performance in masters swimming and running
Authors: De Veaux Richard , Plantinga Anna , Upton Elizabeth 
Published: February 2025

Abstract
The masters movement in swimming and running has exploded, resulting in an abundance of data to study the impact of age on performance. Analyzing data from masters events in running and swimming for athletes aged 35 to 80, we model the percentage increase in event time (or decrease in performance) by age and sex via stacked models that combine polynomial models, neural networks, and natural splines. To answer fundamental questions on the nature of performance decline for competitive athletes, we bootstrap the procedure to obtain confidence intervals. Cross-sectional masters data from the past decade are used to construct models, and the model predictions are compared to the trajectory of current world records by age and to estimates of decline using longitudinal data. Furthermore, the study explores the impact of constituent year, birth cohort, and participation effects, emphasizing the challenges in distinguishing age-related decline from factors like evolving training practices and varied participation rates. Our results give evidence that men generally decline more slowly than women, performance declines more rapidly for endurance events, athletes who participate more frequently decline more slowly than others, and masters level runners decline at rates roughly equivalent to world record holders.
Особливості функціонування ЗМІ національних меншин в Україні та інших країнах Європи: на прикладі Швеції
Authors: Sardarian Karynna 
Published: February 2025

У статті досліджуються особливості функціонування національних ЗМІ етнічних меншин в Україні та Швеції, акцентується увага на їхній ролі у збереженні мовної й культурної ідентичності та значенні у суспільно-політичному житті. Аналізуються правові, соціальні та економічні аспекти діяльності цих медіа, їхня роль у процесах інтеграції та забезпеченні інформаційної доступності. Здійснено порівняльний аналіз українського та шведського досвіду, включаючи вплив державної політики, європейських стандартів і міжнародних зобов’язань на розвиток етнічних ЗМІ. Представлено контент-аналіз і результати соціологічного опитування серед представників етнічних меншин обох країн. Виявлено ключові індикатори: значущість етнічних медіа для збереження культурної ідентичності, частоту їхнього використання, вподобання аудиторії та бар’єри. Близько 80 % респондентів в Україні та 75 % у Швеції вважають, що етнічні ЗМІ відіграють важливу роль у підтримці мови та традицій. Обидві країни демонструють переважну орієнтацію на цифрові платформи, що відповідає сучасним медіа-трендам. Водночас фінансування, кадрове забезпечення та доступність контенту залишаються викликами. Дослідження засвідчило значні відмінності в державній підтримці етнічних медіа: в Україні їхній розвиток ускладнюється фінансовими обмеженнями, політичною нестабільністю та мовною політикою, тоді як у Швеції стабільне законодавство й державна підтримка сприяють їх розвитку. Зроблено висновок, що національні ЗМІ є ключовим механізмом не лише для збереження культурної ідентичності, а й для інтеграції меншин у суспільство. Вони сприяють міжетнічному діалогу, зменшенню стереотипів і зміцненню соціальної згуртованості. Ефективний розвиток етнічних медіа потребує комплексної державної підтримки, що включає законодавчі ініціативи, фінансування та освітні програми
A Practitioner–Scholar Model to Conceptualize Resilience Interventions in Trauma Therapy
Authors: Temple Michell L. , Faulhaber Erica M. 
Published: February 2025

Abstract
This article provides mental health professionals (MHPs) with a conceptual framework to identify and describe the resilience interventions within a selected form of trauma therapy. The guide uses the practitioner–scholar model to facilitate MHPs’ ability to develop practice-based research to answer the question: How does the trauma therapy used in their clinical practices develop and restore resilience in identified clients? The proposed conceptual framework guides readers through a two-step process. The process involves conducting a literature review and aligning resilience domains with a treatment model. A case study example illustrates the practitioner–scholar conceptual framework situated within the literature focused on resilience. Limitations and implications of MHPs’ practice-based research endeavors are discussed.
ESCRITA, HISTÓRIA E DIFERENÇA PELAS MARGENS DO RIO NEGRO: territorialidades do contato no romance Um rio sem fim, de Verenilde Pereira
Authors: MELO CIMARA VALIM DE 
Published: February 2025

As narrativas do contato interétnico em território amazônico abarcam encontros e confrontos, os quais podem ser visualizados a partir das noções de identidade, etnicidade e diferença. Desse modo, a escrita decolonial possui papel fundamental de memória e denúncia, reforçando-se enquanto caminho de resistência em face de ações de silenciamento e extermínio sofridas pelos povos indígenas devido a colonialismos perpetuados ao longo da história. Ao pensarmos na produção acadêmica e literária amazônida, a escrita de Verenilde Santos Pereira, autora afroindígena, é um caminho que se abre pelas águas do Rio Negro, trazendo consigo o entrecruzamento entre história e literatura pela narrativa de traços autobiográficos, na qual vozes femininas narram traumas históricos, questionam verdades cristalizadas e desafiam o apagamento. Com base no exposto, o presente estudo busca realizar uma leitura do romance Um rio sem fim (1998), tomando, para isso, a pesquisa de caráter bibliográfico e documental, cujos caminhos de investigação passam pelos estudos decoloniais e pelo entrelaçamento entre história e literatura. A partir da análise, observamos que a obra pode ser considerada fundamental quando lançamos o olhar sobre a condição de mulheres nativas do território amazônico a partir da escrita decolonial da história empreendida na contemporaneidade.

Palavras-chave: Narrativa decolonial. Identidade e diferença. Escrita afroindígena.
Implementation of EcoSufism-Based Learning in Creating Mental Balance of Santri in Pesantren
Authors: Masturin Masturin , Nadhirin Nadhirin 
Published: February 2025

<p class="07KatakunciKeywords">This study aims to explore the implementation of ecosufism-based learning in pesantren and its role in shaping environmentally conscious students while achieving mental balance. This research was conducted at Al Mawaddah Islamic Boarding School in Kudus and Edi Mancoro Islamic Boarding School in Salatiga. Data were collected through observation, interviews, and documentation, and analyzed using descriptive thematic approach. The Al-Mawaddah Islamic Boarding School integrates the agricultural sector as a medium to cultivate students with spiritual, intellectual, leadership, and entrepreneurial excellence. Students uphold agricultural environments through eco-friendly practices as devotion to Allah. Meanwhile, the Edi Mancoro Islamic Boarding School incorporates ecosufism into the curriculum of its Islamic boarding school and affiliated educational institutions. Creating aesthetically pleasing surroundings while preserving a rural atmosphere reflects the institution's commitment to upholding eco-conscious and traditional practices. An Islamic-based environmental curriculum should address global challenges, promote environmental appreciation, and align with Islamic principles in education.</p>
COVID-19 Policies and Sexually Transmitted Infections in 22 US States, January 2020–December 2021
Authors: Pollack Catherine C. , Redd Georgia H. , Timm Collin M. , Manabe Yukari C. 
Published: February 2025

Objectives. To quantify the effects of 5 jurisdiction-level COVID-19 policies on chlamydia, gonorrhea, and syphilis rates in 22 US jurisdictions between January 2020 and December 2021. Methods. We applied a mixed-effects, negative binomial, interrupted time series model to estimate the impact that each policy of interest had on reported cases. Results. Mandatory stay-at-home periods were associated with a decrease in reported chlamydia (incident rate ratio [IRR] = 0.75; 95% confidence interval [CI] = 0.71, 0.80) and gonorrhea (IRR = 0.85; 95% CI = 0.78, 0.94) cases. We also observed decreased chlamydia case reporting when gatherings were restricted to 10 people (IRR = 0.88; 95% CI = 0.85, 0.92), masking was recommended (IRR = 0.90; 95% CI = 0.85, 0.97), or polymerase chain reaction testing was limited to symptomatic individuals (IRR = 0.72; 95% CI = 0.67, 0.77). Universal vaccine access corresponded to decreases in reported gonorrhea (IRR = 0.83; 95% CI = 0.75, 0.92) but increases in syphilis (IRR = 1.33; 95% CI = 1.04, 1.70) cases. We also observed effects by sex, race, and ethnicity. Conclusions. COVID-19 policies had disparate effects on sexually transmitted infection rates that varied across demographic groups. Overall results were attenuated after the first lockdown period (March–May 2020), but demographic variations persisted. ( Am J Public Health. Published online ahead of print February 21, 2025:e1–e10. https://doi.org/10.2105/AJPH.2024.307957 )
Housing Quality Metric (HQM): Neighborhood-Level Data, Housing Quality, and Population Health
Authors: Garrison Veronica , Ashley Peter J. , Moran Alyssa J. , Cudjoe Thomas K. M. , Perrin Eliana M. , Pollack Craig Evan 
Published: February 2025

Objectives. To develop a national, tract-level measure of neighborhood housing quality and test its validity by examining associations with population health metrics. Methods. Using microdata from the 2021 American Housing Survey postfit to the 2018–2022 American Community Survey, we developed the Housing Quality Metric (HQM), which predicts the likelihood that a US census tract contains a large share of poor-quality housing units across 3 domains: physical inadequacy, housing cost burden, and poor neighborhood perception. We then used regression models to assess the ecological association between HQM and area-level measures of adult population health (fair or poor general health, poor mental health, and poor physical health) from the PLACES data set. Results. Census tract HQM score was significantly associated with a higher predicted proportion of adults self-reporting all 3 examined negative health status outcomes in both unadjusted and adjusted models. Conclusions. HQM presents the first national, tract-level measure of poor housing quality that has significant associations with adult population health status. Public Health Implications. HQM can be used to target resources and interventions in ways that may better capture the complex relationship between housing quality and population health than existing measures of housing quality. ( Am J Public Health. Published online ahead of print February 21, 2025:e1–e9. https://doi.org/10.2105/AJPH.2024.307962 )