bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characterization of trigeminal C‐fiber reactivity through capsaicin‐induced release of calcitonin gene‐related peptide
Authors: Basedau Hauke , Oppermann Thalea , Gundelwein Silva Elisa , Peng Kuan‐Po , May Arne 
Published: January 2023

AbstractObjectiveWe hypothesized that the response of trigeminal dermal blood flow (DBF) in the trigeminal system and consecutive expansion of flare response to capsaicin would differ from the somatosensory system (arm). We also investigated whether there are differences between patients with migraine and healthy controls (HC).BackgroundFunctional differences between the trigeminal and extracephalic somatosensory systems may partly explain the susceptibility for headaches in patients with migraine. Capsaicin‐induced activation of nociceptive C‐fibers in the skin is mainly mediated by calcitonin gene‐related peptide (CGRP) and induces cutaneous vessel dilatation and flare response.MethodsFemale patients with migraine (n = 38) and age‐matched HC (n = 35) underwent DBF measurement at baseline and after topical capsaicin administration using laser speckle imaging. DBF before and after capsaicin stimulation was analyzed over ophthalmic nerve/maxillary nerve/mandibular nerve (V1/V2/V3) dermatomes and the forearm as an extracephalic control.ResultsCapsaicin‐induced DBF increased more in the trigeminal dermatomes than on the forearm. The V1 dermatome showed a smaller increase of DBF in patients with migraine compared to HC.ConclusionOur results suggest that the trigeminovascular system reacts differently from extracephalic areas, which may explain the trigeminal susceptibility to CGRP‐mediated pain attacks. By demonstrating a different reactivity of the V1 dermatome in patients with migraine, our finding suggests that the first trigeminal branch is functionally different from the second and third branches; however, only in patients with migraine.
Headache education by leaflet distribution during COVID‐19 vaccination and school‐based on‐demand e‐learning: Itoigawa Geopark Headache Awareness Campaign
Authors: Katsuki Masahito , Matsumori Yasuhiko , Kawahara Junko , Yamagishi Chinami , Koh Akihito , Kawamura Shin , Kashiwagi Kenta , Kito Tomohiro , Oguri Masato , Mizuno Shoji , Nakamura Kentaro , Hayakawa Katsushi , Ohta Osamu , Kubota Noa , Nakamura Hina , Aoyama Jun , Yamazaki Isamu , Mizusawa Satoshi , Ueki Yasuhide , Nanri Maiko , Miyakoshi Yuki , Gobo Shuto , Entani Akio , Yamamoto Toshiko , Otake Miyako , Ikeda Takashi , Matsuo Mitsuhiro , Yamagishi Fuminori 
Published: January 2023

AbstractObjectiveWe prospectively performed the Itoigawa Headache Awareness Campaign from August 2021 to June 2022, with two main interventions, and evaluated its effectiveness.BackgroundHeadache is a common public health problem, but its burden could be reduced by raising awareness about headache and the appropriate use of acute and prophylactic medication. However, few studies on raising headache awareness in the general public have been reported.MethodsThe target group was the general public aged 15–64. We performed two main interventions synergistically supported by other small interventions. Intervention 1 included leaflet distribution and a paper‐based questionnaire about headache during COVID‐19 vaccination, and intervention 2 included on‐demand e‐learning and online survey through schools. In these interventions, we emphasize the six important topics for the general public that were described in the Clinical Practice Guideline for Headache Disorders 2021. Each response among the two interventions’ cohorts was collected on pre and post occasions. The awareness of the six topics before and after the campaign was evaluated.ResultsWe obtained 4016 valid responses from 6382 individuals who underwent vaccination in intervention 1 and 2577 from 594 students and 1983 parents in intervention 2; thus, 6593 of 20,458 (32.2%) of the overall working‐age population in Itoigawa city experienced these interventions. The percentage of individuals’ aware of the six topics significantly increased after the two main interventions ranging from 6.6% (39/594)–40.0% (1606/4016) to 64.1% (381/594)–92.6% (1836/1983) (p < 0.001, all).ConclusionsWe conducted this campaign through two main interventions with an improved percentage of individuals who know about headache. The two methods of community‐based interventions could raise headache awareness effectively. Furthermore, we can achieve outstanding results by doing something to raise disease awareness during mass vaccination, when almost all residents gather in a certain place, and school‐based e‐learning without face‐to‐face instruction due to the COVID‐19 pandemic.
Examining consumer food waste through grocery retailers' customer data: Segments and practical implications
Authors: Närvänen Elina , Mesiranta Nina , Saarijärvi Hannu , Nevalainen Jaakko 
Published: January 2023

AbstractGrocery retailers have a large amount of societally relevant data on food purchases in their databases, which they have traditionally used merely for marketing purposes. However, despite the potential, the data have so far been rarely used in sustainability‐related research. This study addresses a key sustainability challenge—the reduction of food waste—by using retailers' customer data and a questionnaire. This paper's purpose is to identify and analyse household food waste segments and discuss their actual purchasing behaviour patterns. By doing so, we also illustrate and exemplify the potential use of customer loyalty card data to address global challenges related to food at the consumer level. The study utilizes an extensive data set of food purchases together with a survey of self‐reported reasons for food waste in households. Utilizing cluster analysis, Phase 1 identifies six household segments: no food waste; trust in date labels; safety first; occasional wasters; overpurchasers and overpreparers; and family first. These segments differ in their sociodemographic and purchase profiles. In Phase 2, these segments' purchasing behaviour is examined further by applying tree‐based methods. This study contributes to food waste research and studies on sustainable retailing. It also has practical implications for how retailers can facilitate household food waste reduction.
Consumer views of melanoma early detection using 3D total‐body photography: cross‐sectional survey
Authors: Hona Te Wai Pounamu T. , Horsham Caitlin , Silva Carina V. , Lawn Craig , Sanjida Saira , Gillespie Nicole , Soyer H. Peter , Janda Monika ,   the ACEMID group
Published: January 2023

AbstractBackgroundThree‐dimensional (3D) total‐body photography is a recent advance in melanoma early detection that can aid in monitoring and identifying new and changing skin lesions over time.MethodsA cross‐sectional survey of adults living in metropolitan and rural areas of Australia was conducted to assess perceptions of 3D total‐body photography. Participants completed a survey detailing their previous use of skin cancer photography, personal skin checking history, perceptions of 3D total‐body photography, and willingness to pay. Participants were also asked to describe the potential barriers and facilitators of 3D total‐body photography in their own words.ResultsA total of 1056 participants completed the survey, with 739 (70%) from metropolitan areas of Australia and 317 (30%) from rural areas. Most participants (95%, n = 1004/1056) indicated they would consider using 3D total‐body photography if it became commercially available at their regular medical practice. Most participants indicated 3D total‐body photography would be effective to identify suspicious skin spots (94%, n = 995/1056), monitor lesion changes (94%, n = 997/1056), and reduce skin cancer related anxiety (90%, n = 950/1055). In open‐ended feedback, participants (87%, n = 918/1056) identified perceived benefits, including more comprehensive screenings, earlier detection, and less human error. Participants (84%, n = 889/1056) also identified potential barriers to 3D total‐body photography, including cost, accessibility and availability, trust in the technology, and digital security concerns.ConclusionsParticipant feedback indicated a high level of acceptance and confidence in the technology. To facilitate clinical translation, addressing consumer‐identified barriers to 3D total‐body photography will be vital.
Association of gut microbiota and glucose metabolism in children with disparate degrees of adiposity
Authors: Yuan Xin , Zhang Ying , Lin Xiangquan , Yang Xiaohong , Chen Ruimin 
Published: January 2023

SummaryObjectiveTo investigate the characteristics of gut microbiota in children with disparate degrees of adiposity, and analyze the association between gut microbiota, glucose metabolism indicators, and inflammatory factors.MethodsClinical data were examined in 89 Chinese children. Children with a body fat percentage ≥ 30% were diagnosed as obese, and ≥ 35% in males and ≥ 40% in females were further defined as severe obesity. The composition of gut microbiota was determined by 16S rDNA‐based metagenomics.ResultsThe study population (9.75 ± 1.92‐year‐old) was characterized as normal weight (n = 29), mild obesity (n = 27) and severe obesity (n = 33) groups. Linear discriminant analysis Effect Size (LEfSe) analysis found that compared to the severe obesity group, subjects with mild obesity had more prevalent members of the phylumFusobacteria,thegenusAlistipes, and fewer members of genusGranulicatellaandClostridium(p < 0.05).For subjects with mild obesity, Spearman's correlation analysis revealed that fasting plasma glucose positively correlated with speciesA. indistinctus,A. putredinis, and negatively correlated with speciesRuminococcus gnavus; LBP negatively correlated with speciesClostridium hathewayi, andBlautia producta. For subjects with severe obesity, oral glucose tolerance test 2 h plasma glucose (OGTT2HPG) negatively correlated with the phylumSynergistetes, genusPyramidobacter, speciesVeillonella parvula,P. piscolens, and positively correlated with speciesB. producta, INS and HOMA‐IR negatively correlated with the genusHaemophilus, speciesH. parainfluenzae, lipopolysaccharide‐binding protein (LBP) negatively correlated with the phylumActinobacteria, genusBifidobacterium,Lactobacillus, and speciesB. longum(allp < 0.05).Phylogenetic investigation of communities by reconstruction of unobserved states 2 (PICRUSt2) analysis discerned that the glucose metabolism pathway, gluconeogenesis I was curtailed in the severe obesity group.ConclusionThe gut microbiota could favourably compensate for glucose metabolism in children with obesity. GenusHaemophilusandBifidobacterium longummay influence glucose tolerance and insulin resistance in children with severe obesity.
In Semliki Forest virus encephalitis, suppressor of cytokine signaling 4 (SOCS4) is an essential modulator of immune responses that mediates the balance between immunopathology and virus clearance
Authors: Kedzierski Lukasz , Er Qi Tan Abigail , Jia Hui Foo Isabelle , Narayanan Divya , Moily Nagaraj , McQuilten Hayley A , Nicholson Sandra E , Fazakerley John K 
Published: January 2023

AbstractCentral nervous system virus infections are a major cause of morbidity and mortality worldwide and a significant global public health concern. As in many tissues, inflammation and immune responses in the brain, despite their protective roles, can also be harmful. Control of brain inflammation is important in many neurological diseases from encephalitis to multiple sclerosis and neurogenerative disease. The suppressors of cytokine signaling (SOCS) proteins are a key mechanism controlling inflammatory and immune responses across all tissues including the brain. Using a mouse model system, we demonstrate that lack of SOCS4 results in changes in the pathogenesis and clinical outcome of a neurotropic virus infection. Relative to wild‐type mice, SOCS4‐deficient mice showed accelerated clearance of virus from the brain, lower levels of persisting viral RNA in the brain, increased neuroinflammation and more severe neuropathology. We conclude that, in the mouse brain, SOCS4 is a vital regulator of antiviral immunity that mediates the critical balance between immunopathology and virus persistence.
A study on the optimal shareholding proportion of the controlling shareholders in the competitive mixed‐ownership enterprises: Evidence from Chinese listed companies
Authors: Zhang Qiwang , Wang Xiaorui , Huo Chunhui , Shulin Wang 
Published: January 2023

AbstractThere is a wide debate on the optimal shareholding proportion of controlling shareholders. Under the background of China's mixed‐ownership reform, this paper focuses on a specific firm setting of mixed‐ownership enterprises in fully competitive industries, and tries to find the heterogeneity in the association between controllers' shareholding and firm performance. Specifically, with a sample of China's A‐share listed companies from 2007 to 2018, we find significant differences in this relationship due to different types of controlling shareholders. The effect of controller shareholding on firm performance is not significant in foreign‐controlled enterprises, while that of private enterprises presents a monotone increasing linear relation with statistical significance. No optimal controlling shareholding interval is found in either foreign‐controlled or private‐controlled enterprise. In state‐controlled enterprises, we find an overall inverted U‐shaped with local stage linear relationship between state‐controlling enterprises' controller shareholding and firm performance. The optimal interval of state‐controlling shareholding is 42%–68%.
Submicron mullite hollow spheres synthesized via UV polymerization of Pickering emulsions
Authors: Yang Junjie , Zhang Xiaoyan , Li Wenhao , Yang Jinlong 
Published: January 2023

AbstractWe here propose a simple, facile, and effective method to prepare submicron mullite hollow spheres templated from Pickering emulsions. Dual‐phase sol consisted of boehmite and silica nanoparticles decorated by pentanoate ion could assemble at water/oil interface irreversibly to form photosensitive Pickering emulsions. The droplets of emulsions could be separated by dilution and formed by photopolymerization to gain hybrid microspheres, which could completely transform to mullite hollow microspheres via binder removal and sintering. It is found that the prepared hollow microspheres possess intact morphology, favorable sphericity, large cavity volume, and bulk density of 0.356 g/cm3. Importantly, the average diameter of mullite hollow spheres obtained via this method could be as low as 0.33–2.31 μm. This steady method is efficient and suitable for various types of inorganic particles, providing an innovative perspective for preparing fine hollow spheres applicable for filtration, drug loading as well as energy storage areas.
The effect of risk perception, mask use, and social distance behavior on perceived stress in the COVID‐19 process: A sectional study
Authors: Ayran Gülsün , Çevik Özdemir Hamide Nur , Yaman Ece 
Published: January 2023

AbstractPurposeThis study was carried out to determine the effect of high school students' perception of risk of COVID‐19, wearing masks and social distance behavior on stress during the COVID‐19 pandemic.MethodThis descriptive study was performed on 1034 participants between the ages of 15 and 18 between June 21 and July 2, 2021. “Descriptive Questionnaire,” “COVID‐19 Risk Perception Form,” “Mask Wear Behavior Form,” “Social Distance Behavior Form,” and “Perceived Stress Scale” were used in data collection.ResultsIt was determined that 81.4% of the students used disposable medical masks, and 50.6% of them used the mask they wore for one day. In the characteristics of the risk perception of COVID‐19, 31% have a risk perception, 45% are afraid to contact people returning from abroad, 58.8% avoid going to crowded places, 66.8% are afraid of contacting people with flu symptoms. It was found that they always kept sufficient distance while communicating with others. As a result of the multiple regression, it was determined that gender, mask type, mask usage frequency, risk perception, social distance behavior, and mask‐wearing behavior had a statistically significant effect on the perceived stress level (p < 0.05).ConclusionsThese results provide theoretical inferences for public health policies targeting the high school students to develop accurate risk perception and protective behaviors.
De facto time‐varying indices‐based benchmarks for mutual fund returns
Authors: Cheng Tingting , Yan Cheng , Yan Yayi 
Published: January 2023

AbstractWe question time‐invariant indices as fund benchmarks and propose a regime‐switching methodology to identify time‐varying de facto benchmarks from a pool of market‐based indices, with or without a risk‐free asset. To ameliorate the benchmark mismatch issue, we highlight the importance of using time‐varying indices‐based benchmarks for fund performance evaluation. Our de facto benchmark captures fund styles better than other benchmark choices, substantially improves the identification of significant fund alphas, and provides better out‐of‐sample forecasts. We uncover several new findings in terms of fund performance evaluation using our de facto benchmarks.
Effects of eHealth interventions on stress reduction and mental health promotion in healthcare professionals: A systematic review
Authors: López‐Del‐Hoyo Yolanda , Fernández‐Martínez Selene , Pérez‐Aranda Adrián , Barceló‐Soler Alberto , Bani Marco , Russo Selena , Urcola‐Pardo Fernando , Strepparava Maria Grazia , García‐Campayo Javier 
Published: January 2023

AbstractAimsTo evaluate the effectiveness of eHealth interventions to reduce stress and promote mental health in healthcare professionals, and to compare the efficacy of different types of programs (guided vs. self‐guided; ‘third‐wave’ psychotherapies vs. other types).BackgroundHealthcare workers present high levels of stress, which constitutes a risk factor for developing mental health problems such as depression and anxiety. eHealth interventions have been designed to reduce these professional's stress considering that the characteristics of this delivery method make it a cost‐effective and very appealing alternative because of its fast and easy access.DesignA systematic review of quantitative studies.MethodsA comprehensive database search for quantitative studies was conducted in PubMed, EMBASE and Cochrane (until 1 April 2022). The systematic review was conducted in accordance with the PRISMA and SWiM reporting guidelines. The quality of the studies was assessed using the National Heart, Lung and Blood Institute tools.ResultsThe abstracts of 6349 articles were assessed and 60 underwent in‐depth review, with 27 fulfilling the inclusion criteria. The interventions were classified according to their format (self‐guided vs. guided) and contents (‘third‐wave’ psychotherapies vs. others). Twenty‐two interventions emerged, 13 of which produced significant posttreatment reductions in stress levels of health professionals (9 self‐guided, 8 ‘third wave’ psychotherapies). Significant effects in improving depressive symptomatology, anxiety, burnout, resilience and mindfulness, amongst others, were also found.ConclusionThe evidence gathered in this review highlights the heterogeneity of the eHealth interventions that have been studied; self‐guided and ‘third‐wave’ psychotherapy programs are the most common, often with promising results, although the methodological shortcomings of most studies hinder the extraction of sound conclusions.Protocol registrationPROSPERO CRD42022310199. No Patient or Public Contribution.
Wear at the implant–framework interface between titanium implant platform and the additively manufactured titanium and cobalt–chromium frameworks
Authors: Revilla‐León Marta , Barmak Abdul B. , Rubenstein Jeffrey , Özcan Mutlu 
Published: January 2023

AbstractPurposeTo measure the wear at the implant interface between the Grade 4 titanium (Ti) of the implant and frameworks fabricated using two additively manufactured alloys (Ti alloy and cobalt–chromium [Co–Cr]) pre‐ and post‐artificial aging.Material and methodsThree‐unit frameworks supported by two implants were additively manufactured (Atlantis; Dentsply Sirona) using Ti and Co–Cr dental alloys. Two implants (OsseoSpeed EV, Astra Tech; Dentsply Sirona) were torqued on each non‐engaging framework. The assembled implant–frameworks were secured into polyurethane foam blocks. Groups were created based on the material and surface assessed: framework (Ti‐framework and Co–Cr‐framework groups) and implant (Ti‐implant group). Two subgroups were created depending on the location: premolar (PM) and molar (M). Computed tomography images were obtained pre‐ (as manufactured) and post‐simulated mastication procedures. The pre‐ and post‐simulated mastication files of each specimen were aligned using the best‐fit algorithm using a metrology program. Wear was measured by calculating the volumetric discrepancies at the implant interface on 64 measurement points per area analyzed. Three‐way ANOVA and Tukey tests were used to analyze the data (α = 0.05).ResultsThe mean volumetric discrepancy values ranged from 0.8 to 3.1 µm among all the subgroups tested. The group (framework vs. implant) (p < 0.001) and tooth location (p < 0.001) were significant factors of the mean volumetric discrepancy values obtained. The framework group presented with significantly lower volumetric discrepancy mean values (1 µm) compared with the implant group (3 µm), whereas the premolar area obtained significantly lower mean volumetric discrepancy values (1.9 µm) compared with the molar location (2.3 µm).ConclusionsVolumetric discrepancies were found at the implant–framework interface tested between the pre‐ and post‐artificial aging measurements ranging from 1 to 3 µm after 1,200,000 cyclic loading that simulated approximately 12 months of function.
Tackling pandemic‐related health grand challenges: The role of organizational ambidexterity, social equality, and innovation performance
Authors: Christofi Michael , Stylianou Ioanna , Hadjielias Elias , De Massis Alfredo , Kastanakis Minas N. 
Published: January 2023

AbstractThe outbreak of COVID‐19 has brought the world to a standstill, with severe consequences on economic and health systems, requiring the identification and implementation of innovative solutions. This study's aims are threefold: first, to examine the impact of balanced and combined dimensions of ambidexterity on for‐profit organizations' innovation performance related to pandemics; second, to uncover whether and to what extent such innovation performance contributes to tackling global health grand challenges (i.e., mortality rate, risk of infection, and life expectancy) associated with pandemics; and, third, to investigate the moderating role of social equalities in health in the relationships between innovation performance and health‐related outcomes associated with pandemics. To uncover how for‐profit firms tackle the health‐related consequences of pandemics, we examine whether they have introduced product innovations to the health sector, defined as the market introduction of a new or significantly improved good, that have helped address the health challenges associated with the COVID‐19 pandemic. Using a panel dataset (1974–2020) with 15,062 firm‐year observations from the United States, we show that both the separate and the synchronous implementation of the balanced and combined dimensions of ambidexterity have a strong positive effect on firms' innovation performance and, particularly, innovation initiatives related to the pandemic. The results also reveal that innovation activities (i.e., granted patents and citations focused on COVID‐19) negatively affect mortality rate and risk of infection, as well as the positive impact of innovation on increasing life expectancy, with social equalities in health moderating this relationship. Taken together, we make novel contributions to the literature on how to tackle the health‐related consequences of pandemics through innovation and provide actionable managerial guidance on how firms can enhance innovation performance.