bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nurses' Perceptions of Patients With Co‐Occurring Psychiatric and Substance Use Disorders in Psychiatric Settings: A Grounded Theory Study
Authors: Bertrand Etienne , Morvillers Jean‐Manuel 
Published: January 2025

ABSTRACTAimTo explore psychiatric and mental health nurses' perceptions of patients with co‐occurring psychiatric and substance use disorders in psychiatric settings.DesignAn exploratory qualitative study design based on grounded theory, employing Straussian analytic procedures.MethodSemi‐structured interviews were conducted with 11 psychiatric and mental health nurses. Participants were recruited at a public psychiatric hospital located in the Paris metropolitan area of France. Face‐to‐face interviews took place between February 2024 and May 2024. Field notes and interview data were continuously analysed during open, axial and selective coding phases.ResultsThe core category identified was ‘waiting for a patient's will to change to emerge’ when caring for patients with co‐occurring substance use disorders. This active waiting period involved a balancing strategy between two discrete care objectives: stabilising the patient's clinical status and keeping the nurse‐patient relationship intact. Identifying a patient's will to change provided an opportunity to reconcile these two aspects of psychiatric nursing through the addition of a collaborative component to the relationship.ConclusionThe substantive theory generated by our findings contributes to understanding the interactional and relational processes that occur between nurses and patients presenting with co‐occurring substance use disorders in the context of psychiatric care.Implications for the Profession and/or Patient CareImplications of our study include the need for further emphasis on collaborative approaches that can be applied even in early or pre‐contemplative stages of recovery. Organisational policies should systematically include training in the field of addiction care, given the high prevalence of co‐occurring substance use disorders in psychiatric settings.ImpactOur findings can assist nurses in critically examining the challenges they experience when engaging with patients with co‐occurring substance use disorders.Reporting MethodThis research adheres to the COREQ (COnsolidated criteria for REporting Qualitative research) Checklist.Patient or Public ContributionNo patient or public contribution.
Morphological study of the anterior dentition in Raoellidae (Mammalia, Artiodactyla), new insight on their dietary habits
Authors: Bouaziz Hugo , Orliac Maëva J. , Waqas Mohd , Rana Rajendra Singh , Smith Thierry , Weppe Romain 
Published: January 2025

AbstractRaoellidae are small artiodactyls from the Indian subcontinent closely related to stem cetaceans. They bring crucial information to understand the early phase of the land‐to‐water transition in Cetacea. If they are considered to be partly aquatic, the question of their dietary habits remains partly understood due to their “transitional” morphology. Raoellidae are largely documented by their cheek teeth and getting a better knowledge of their anterior dentition constitutes an additional proxy to discuss their feeding habits. In this work, we document the anterior dentition of Indohyus indirae from an unprecedented sample of in situ and isolated teeth from the locality of East Aiji‐2 in the Kalakot area (Rajouri district, India). We propose identification criteria for upper and lower incisors and canines in raoellids. Based on CT scan data, virtual reconstruction of in situ dentition, and identification of the isolated incisors and canines, we reconstruct a composite anterior dentition of Indohyus supported by the correspondence of wear facets between upper and lower teeth. This constitutes the first attempt at reconstruction of the anterior dentition of a raoellid. We show that the upper incisors are caniniform and very similar morphologically, whereas the lower incisors are pointed but remain incisiform and quite different from one another. We also describe noticeable intraspecific variation, at the level of upper canines, suggesting a potential sexual dimorphism in this species. Upper and lower incisors are recurved, with the upper incisor row arranged on a widely opened arch. Taken altogether the anterior dentition forms a grasping device, allowing the animal to capture and secure food, a characteristic shared with stem cetaceans. This would mark the first step towards the carnivorous diet in these peculiar artiodactyls.
In Vivo Nitrosative Stress‐Induced Expression of a Photolyase Promotes Vibrio cholerae Environmental Blue Light Resistance
Authors: Banerjee Arkaprabha , Byun Hyuntae , Hrycko Andrew J. , Pu Qinqin , Brockett Mary R. , Esteves Nathaniel C. , Miller Jennifer R. , Li Qiushi , Ma Amy T. , Zhu Jun 
Published: January 2025

ABSTRACTBacterial pathogens possess a remarkable capacity to sense and adapt to ever‐changing environments. For example, Vibrio cholerae, the causative agent of the severe diarrheal disease cholera, thrives in aquatic ecosystems and human hosts through dynamic survival strategies. In this study, we investigated the role of three photolyases, enzymes that repair DNA damage caused by exposure to UV radiation and blue light, in the environmental survival of V. cholerae. Among these, we identified cry1 as critical for resistance to blue light, as mutations in this gene, but not in the other photolyase genes, rendered V. cholerae susceptible to such stress. Expression of cry1 was induced by blue light and regulated by RpoE and the anti‐sigma factor ChrR. We further showed that nitric oxide (NO), a host‐derived stressor encountered during infection, also activated cry1 expression. We found that one of the two cysteine residues in ChrR was important for sensing reactive nitrogen species (RNS), thereby modulating cry1 expression. While Cry1 was not required for V. cholerae colonization in animal models, pre‐induction of Cry1 by RNS in vivo or in vitro enhanced V. cholerae resistance to blue light. These findings suggest that host‐derived NO encountered during infection primes V. cholerae for survival in blue‐light‐rich aquatic environments, supporting its transition between host and environmental niches.
Effectiveness of Cognitive Behavioral Therapy in Reducing Psychological Distress in Nurses: A Systematic Review and Meta‐Analysis of Experimental Studies
Authors: Badriyah Fatin Lailatul , Suarilah Ira , Tarihoran Dame Elysabeth Tuty Arna Uly , Saragih Ita Daryanti , Lee Bih‐O. 
Published: January 2025

ABSTRACTWork‐related stress, a major contributor to physical and mental health issues of nurses, has a direct impact on patient safety and nurses' well‐being. However, few studies have investigated the effectiveness of cognitive behavioral therapy in reducing psychological distress in nurses. Systematic search of six databases including CINAHL Plus with Full Text, Cochrane Library, Embase, Medline, PubMed, and Web of Science from their inception to February 27, 2024. The primary outcomes assessed were reductions in stress, anxiety, and depression following the implementation of cognitive behavioral therapy. A random effects model, accounting for study differences, was applied in the meta‐analyses. Egger's regression test was utilized to assess potential publication bias in the pooled analyses. The meta‐analysis included 10 studies that demonstrated the intervention's beneficial effects in reducing stress, anxiety, and depression among nurses. Despite the positive effects observed with cognitive behavioral therapy (CBT) in alleviating psychological distress among nurses, the generalizability of these findings may require further confirmation due to the diversity of cognitive behavioral therapies.
Subcutaneous Pectoral Edema After Arthroscopic Labral Repair Despite Normal Irrigation Fluid Usage and Surgery Duration
Authors: Ayas İnci Hazal , Akcan Yağız Oğul , Haspolat Miray , Tokgöz Mehmet Ali , Keser İlke , Kanatlı Ulunay 
Published: January 2025

ABSTRACTObjectivesEdema after shoulder arthroscopic surgery poses concerns due to its potential complications such as compartment syndrome, nerve damage, and respiratory issues. This study aimed to investigate the acute accumulation of subcutaneous fluid after shoulder arthroscopy.MethodsA prospective cohort study, providing Level III evidence was conducted on 50 patients undergoing arthroscopic shoulder surgery under interscalene block anaesthesia from September to December 2023. The patients were divided into two groups: rotator cuff repair (RCR, n = 29) and labral repair for shoulder instability (LR, n = 21). Subcutaneous fluid levels were measured preoperatively, postoperatively, and at discharge (24 h postsurgery) using the MoistureMeterD Compact at the neck, pectoral region, deltoid area, cubital fossa, and carpal tunnel. Data on surgery duration and irrigation fluid volume were documented. In the statistical analysis, repeated measures ANOVA and the independent‐samples t‐test were applied to compare parametric data, while the Friedman test and Mann–Whitney U test were used for nonparametric data.ResultsThe average operation time was 29.0 ± 12.1 min for RCR and 30.0 ± 10.9 min for LR, with average irrigation fluid use of 3.8 ± 0.9 and 4.0 ± 0.7 L, respectively (both p > 0.05). There was no increase in subcutaneous edema in the neck and deltoid region in both groups. At discharge, the percentage of subcutaneous fluid increased in the cubital fossa (p = 0.04 for RCR; p < 0.001 for LR) and carpal tunnel (both p < 0.001) in oth groups, whereas pectoral edema increased only in the labral repair group (p = 0.04).ConclusionsSubcutaneous pectoral edema can occur following arthroscopic labral repair, and increased fluid levels in the cubital fossa and carpal tunnel were observed in both rotator cuff and labral repairs, even in the absence of prolonged surgery or excessive irrigation fluid use. These findings highlight the need for careful postoperative management of edema after shoulder arthroscopy, particularly for labral repairs, with special attention to the pectoral region, cubital fossa, and carpal tunnel to prevent potential complications.The registry is sponsored by the United States National Library of Medicine (www.clinicaltrials.gov); Registry Name: Examination of Edema After Arthroscopic Shoulder Surgery ID: NCT06014203.
Enhancing quality and yield of recombinant secretory IgA antibodies in Nicotiana benthamiana by endoplasmic reticulum engineering
Authors: Göritzer Kathrin , Melnik Stanislav , Schwestka Jennifer , Arcalis Elsa , Drapal Margit , Fraser Paul , Ma Julian K‐C. , Stoger Eva 
Published: January 2025

SummaryThe production of complex multimeric secretory immunoglobulins (SIgA) in Nicotiana benthamiana leaves is challenging, with significant reductions in complete protein assembly and consequently yield, being the most important difficulties. Expanding the physical dimensions of the ER to mimic professional antibody‐secreting cells can help to increase yields and promote protein folding and assembly. Here, we expanded the ER in N. benthamiana leaves by targeting the enzyme CTP:phosphocholine cytidylyltransferase (CCT), which catalyses the rate‐limiting step in the synthesis of the key membrane component phosphatidylcholine (PC). We used CRISPR/Cas to perform site‐directed mutagenesis of each of the three endogenous CCT genes in N. benthamiana by introducing frame‐shifting indels to remove the auto‐inhibitory C‐terminal domains. We generated stable homozygous lines of N. benthamiana containing different combinations of the edited genes, including plants where all three isofunctional CCT homologues were modified. Changes in ER morphology in the mutant plants were confirmed by in vivo confocal imaging and substantially increased the yields of two fully assembled SIgAs by prolonging the ER residence time and boosting chaperone accumulation. Through a combination of ER engineering with chaperone overexpression, we increased the yields of fully assembled SIgA by an order of magnitude, reaching almost 1 g/kg fresh leaf weight. This strategy removes a major roadblock to producing SIgA and will likely facilitate the production of other complex multimeric biopharmaceutical proteins in plants.
Natural variation in the GmVPE1 promoter contributes to phosphorus re‐translocation to seeds and improves soybean yield
Authors: Chen Jiaxin , Lian Wenting , Li Zhiang , Guo Xin , Li Yaning , Zhao Hongyu , Yi Keke , Li Xinxin , Liao Hong 
Published: January 2025

SummaryPhosphorus (P) is an essential yet frequently deficient plant nutrient. Optimizing P distribution and recycling between tissues is vital for improving P utilization efficiency (PUE). Yet, the mechanisms underlying the transport and re‐translocation of P within plants remain unclear. Here, wide‐ranging natural diversity in seed P allocation and positive correlations among yield traits were found using 190 soybean accessions in field trials. Among them, the P‐efficient genotype BX10 outperformed BD2 in assessments of PUE that were largely explained through differences in P redistribution from pods to seeds under low P stress. Pods of BX10 were therefore subjected to transcriptome analysis, and GmVPE1 was identified as a vacuolar Pi transporter to investigate further. Importantly, significant DNA polymorphism in GmVPE1 promoter regions was remarkably associated with seed weight among soybean accessions grown on P‐deficient soils. Further analyses suggested that mRNA abundance of GmVPE1 in haplotype 2 (Hap) is significantly higher than that GmVPE1Hap1. GmVPE1 was highly upregulated by P deficiency and preferentially expressed in pods, seeds, and seed coats, which was consistent with GUS staining using transgenic soybean plants carrying pGmVPE1Hap2::GUS. Near‐isogenic lines carrying the GmVPE1Hap2 allele, along with stable transgenic soybeans overexpressing GmVPE1 in a GmVPE1Hap1 background, had increases in PUE, more seed setting, and greater yields in both greenhouse and field trials than control plants. In summary, natural variation among GmVPE1 alleles determines genetic expression and subsequent P re‐translocation phenotypes, which impacts PUE and yield, and thereby makes this an important genetic resource for soybean molecular breeding.
Leaf Size Determines Damage‐ and Herbivore‐Induced Volatile Emissions in Maize
Authors: Waterman Jamie M. , Cofer Tristan M. , Von Laue Ophélie M. , Mateo Pierre , Wang Lei , Erb Matthias 
Published: January 2025

ABSTRACTStress‐induced plant volatiles play an important role in mediating ecological interactions between plants and their environment. The timing and location of the inflicted damage is known to influence the quality and quantity of induced volatile emissions. However, how leaf characteristics and herbivore feeding behaviour interact to shape volatile emissions is not well understood. Using a high‐throughput volatile profiling system with high temporal resolution, we examined how mechanical damage and herbivore feeding on different leaves shape plant‐level volatile emission patterns in maize. We then tested feeding patterns and resulting consequences on volatile emissions with two generalist herbivores (Spodoptera exigua and Spodoptera littoralis), and assessed whether feeding preferences are associated with enhanced herbivore performance. We found maize seedlings emit more volatiles when larger leaves are damaged. Larger leaves emitted more volatiles locally, which was the determining factor for higher plant‐level emissions. Surprisingly, both S. exigua and S. littoralis preferentially consumed larger leaves, and thus maximize plant volatile emission without apparent growth benefits. Together, these findings provide an ecophysiological and behavioural mechanism for plant volatile emission patterns, with potentially important implications for volatile‐mediated plant‐environment interactions.
The relationship between frailty levels and quality of life in patients over 65 years of age receiving regular hemodialysis treatment
Authors: Dilek Sümeyye , Cantekin Işın 
Published: January 2025

ABSTRACTBackgroundThis study was conducted to investigate the relationship between frailty levels and quality of life in patients over 65 years of age receiving regular haemodialysis treatment.Materials and MethodsThe study was designed as a descriptive and correlational study. Data were collected from patients in a university hospital and two private dialysis centres in Konya between August and September 2023. The study sample consisted of 171 patients. The data collection tools included the Descriptive Characteristics Information Form, the Edmonton Frail Scale (EFS), and the EQ‐5D‐5L Quality of Life Questionnaire. Data analysis was performed using the SPSS software program. Frequency and percentage calculations were obtained for the measurements in the personal information form. Since the data in the personal information form and EFS did not show normal distribution, non‐parametric tests, specifically the Mann–Whitney U‐test and the Kruskal‐Wallis H‐test, were used.ResultsThe results obtained in the present study showed a significant, moderate, negative correlation between the quality of life and frailty levels of patients over 65 years of age receiving dialysis treatment.ConclusionThis study demonstrated that as quality of life increased, frailty levels decreased. Improvements in patients' quality of life could potentially lead to a reduction in frailty levels.
CD131 antagonism blocks inflammation, emphysema and fibrosis in an asthma‐COPD overlap mouse model originating in early life
Authors: Wang Hao , Fung Nok Him , Aloe Christian , Miles Mark , Selemidis Stavros , Lopez Angel F. , Wilson Nick , Owczarek Catherine , Bozinovski Steven 
Published: January 2025

AbstractBackground and ObjectiveAsthma‐COPD overlap (ACO) is characterized by patients exhibiting features of both asthma and COPD. Currently, there is no specific treatment for ACO. This study aimed to investigate the therapeutic potential of targeting CD131, a shared receptor subunit for IL‐3, IL‐5 and GM‐CSF, in ACO development and in preventing acute viral exacerbations.MethodsA two‐hit mouse model of ACO was established by house dust mite (HDM) allergen sensitization to model asthma, and elastase treatment to model emphysema. In a separate model, human rhinovirus 1b (RV1b) was used to induce an acute asthma exacerbation. A neutralizing antibody against CD131 was used to block CD131 in vivo signalling.ResultsMice exposed to HDM and elastase developed cardinal features for asthma and COPD, including airway hyperreactivity (AHR) and emphysema. A mixed granulocytic inflammatory profile was identified in the lungs, including expansion of monocyte‐derived macrophages, neutrophils and eosinophils. RT‐qPCR analysis detected heightened gene expression of Mmp12, Il5 and Il13. Transcriptomic analysis further revealed pathway enrichment for type 2 inflammation and macrophage activation. Blockade of CD131 effectively reduced the lung inflammation and prevented the development of AHR, airway fibrosis and emphysema. Interestingly, pathway enrichment for Th1 response and interferon production detected in the model was not affected by the treatment. Consistently, CD131 antagonism prevented RV1b‐induced asthma exacerbation without compromising RV1b clearance.ConclusionCD131 signalling coordinates multiple pathological pathways that drive airway inflammation and lung remodelling in ACO. Hence, CD131 antagonism represents a novel approach to combating the immunopathology in the complex ACO setting.
Nonpharmacological Management of Dental Anxiety in the General Population and Individuals With Learning Disabilities: A Bibliometric Analysis
Authors: Ibrahim Siti Hajar , Mohd Farah Natashah , Yusof Mohd Yusmiaidil Putera Mohd , Chandra Lukman Ade , Ahmi Aidi , Ahmad Mas Suryalis 
Published: January 2025

AbstractAimsDental anxiety (DA) is reported among the general population, including individuals with learning disabilities (LDs). In many studies, nonpharmacological interventions have been applied to significantly improve DA among patients. This study aimed to examine publication trends and patterns in both populations to identify the current research trends and literature gaps.MethodsA descriptive analysis of bibliographic data and network visualization were conducted using Microsoft Excel and VosViewer, focusing on literature published in the Scopus database between 1994 and 2023 and using “title” as the search field.ResultsFor the study period, the following were identified: 1429 authors, 5858 total citations, and an h‐index of 36. From a total of 2058 publications discovered, 363 publications were included in the study. Of these, only 11 articles addressed nonpharmacological management for people with LDs. In terms of the research country, the United Kingdom was the leading contributor, with 56 publications. Ad de Jongh was the most productive author, with 13 publications and 447 citations. The most highly cited paper was Lehrner et al. (2005), with 312 citations.ConclusionThis study determined the number of publications related to nonpharmacological management of DA over three decades. The number of studies involving people with LDs was lower than that involving the general population, suggesting future research should occur in this area.
Future contingents, openness and the possibility of omniscience: Defending an argument against relativism and supervaluationism
Authors: Todd Patrick 
Published: January 2025

AbstractIn a recent paper, Patrick Todd and Brian Rabern argued that—contra both Thomason's supervaluationism and MacFarlane's relativism—an “open future” view is incompatible with the principle they call “Retro‐closure”, according to which today's rain implies that yesterday it was true that it would rain a day later. In a recent piece, MacFarlane replies. This paper has two aims. First, I argue that MacFarlane's response to Todd and Rabern is unsuccessful on its own terms. Second, I attempt to clarify Todd and Rabern's overall argument, and explain how MacFarlane's replies should be construed within the overall dialectic. The intended result: if you want an “open future”, then one's best option is a modified Peirceanism (as in Todd, The Open Future); if one wants Retro‐closure, one's best option is one on which there is a determinate “Thin Red Line” (a view sometimes called “Ockhamism”). However, one cannot have what supervaluationism and relativism both promise, viz., a view that preserves both.