bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fuzzy-Set Qualitative Comparative Analysis (fsQCA) in Organizational Psychology: Theoretical Overview, Research Guidelines, and A Step-By-Step Tutorial Using R Software
Authors: Cangialosi Nicola 
Published: July 2023

Abstract
Fuzzy set qualitative comparative analysis (fsQCA) is a method for assessing the effects of configurations of variables leading to an outcome. The recent growth of interest in this technique in organizational psychology is proving this method to be an important tool for addressing new and decisive research hypotheses. However, the effectiveness of fsQCA is dictated not only by its general principles, but also by how well these are understood and applied in the research community. Consequently, a guide that covers the fundamental ideas and tenets of the approach is required to aid the research community in its comprehension and practical application. The current study seeks to offer an understanding of FsQCA by providing: (a) A complete description of the method highlighting some of the most important theoretical-methodological aspects; (b) a perspective on the most used guidelines and recommendations, and (c) step-by-step instructions on how to carry out FsQCA in R using the QCA package. Data from 120 employees and supervisors derived from a company based in central Italy were used o best to illustrate how to carry out fsQCA. Codes for conducting the analyses from the QCA package for R accompany the tutorial and can be adapted to a new dataset.
Arctic Cloud‐Base Ice Precipitation Properties Retrieved Using Bayesian Inference
Authors: Silber Israel 
Published: July 2023

AbstractCloud‐climate feedbacks are still the greatest source of uncertainty in current climate projections. Arctic clouds, which are predominantly stratiform and supercooled, often long‐lived, and nearly continuously precipitate ice particles, contribute roughly 10% of the uncertainty attributed to the global cloud feedback. This Arctic cloud uncertainty is driven by incomplete observational and theoretical knowledge required to estimate and explain the state and active processes occurring in those clouds. A focus on ice precipitation properties at Arctic cloud base rather than the surface deconfounds the product of cloud condensate sink processes from the influence of the atmospheric thermodynamic state below cloud base, rendering cloud‐base properties a more appealing target for inference and evaluation of model simulations. Here I describe an inverse model for the estimation of cloud base ice precipitation properties over Utqiagvik, North Slope of Alaska, using the synthesis of ground‐based radar and lidar measurements. By leveraging a Markov Chain Monte Carlo algorithm as the core of the inverse model, a wide range of particle size distributions are sampled, and different combinations of ice habit models are examined, both of which are typically fixed in other retrieval methods. Results show intriguing links between different cloud base thermodynamic and ice precipitation properties. Apparent ice number concentration enhancements at temperatures of −5 and −15°C suggest possible secondary ice production (SIP). The analysis alludes to an overestimation of SIP occurrence and intensity, especially in studies relying only on radar or lidar measurements. Finally, reflectivity‐dependent ice precipitation rate and ice water content parameterizations are presented.
Plate Age and Uppermost Mantle Structure Across the Juan de Fuca and Gorda Plates
Authors: Wu Mengyu , Wang Hongda , Zhang Shane , Ritzwoller Michael H. 
Published: July 2023

AbstractTo test the relationship between plate age and uppermost mantle structure for the Juan de Fuca and Gorda plates, as well as the mode of lithospheric cooling, we produce a new 3D oceanic shear wave speed (VS) model. This model is constructed using a new high‐quality Rayleigh wave phase speed data set across the plates and is based on a novel thermo‐seismic hybrid parameterization. In the lithosphere, we find that the VS structure is primarily (68% of study area) governed by conductive cooling. Exceptions are observed, suggesting advective heat influx along ridges and hydrothermal circulation through cracks near the subduction trench and transform faults. In the asthenosphere of the Juan de Fuca plate, no simple monotonic relationship between seismic structure and plate age exists, but instead there is a non‐monotonic slow‐fast‐slow VS pattern from west to east. The two slow asthenospheric VS anomalies indicate the presence of partial melt beneath both the mid‐ocean ridge and the subduction trench. The partial melt beneath the trench is enigmatic.
Spatial Response of Greenland's Firn Layer to NAO Variability
Authors: Brils M. , Kuipers Munneke P. , van den Broeke M. R. 
Published: July 2023

AbstractFirn on the Greenland Ice Sheet (GrIS) buffers meltwater, and has a variable thickness, complicating observations of volume change to mass change. In this study, we use a firn model (IMAU‐FDM v1.2G) forced by a regional climate model (RACMO2.3p2) to investigate how the GrIS firn layer thickness and pore space have evolved since 1958 in response to variability in the large‐scale atmospheric circulation. On interannual timescales, the firn layer thickness and pore space show a spatially heterogeneous response to variability in the North Atlantic Oscillation (NAO). Notably, a stronger NAO following the record warm summer of 2012 led the firn layer in the south and east of the ice sheet to regain thickness and pore space after a period of thinning and reduced pore space. In the southwest, a decrease in melt dominated after 2012, whereas in the east, the main driver was an increase in snow accumulation. At the same time, the firn in the northwestern ice sheet continued to lose pore space. The NAO also varies on intra‐annual timescales, being typically stronger in winter than in summer. This impacts the amplitude of the seasonal cycle in GrIS firn thickness and pore space. In the wet southeastern GrIS, most of the snow accumulates during the winter, when melting and densification are relatively weak, leading to a large seasonal cycle in thickness and pore space. The opposite occurs in other regions, where snowfall peaks in summer or autumn. This dampens the seasonal amplitude of firn thickness and pore space.
Predicting mental and psychomotor delay in very pre-term infants using machine learning
Authors: Demirci Gözde M. , Kittler Phyllis M. , Phan Ha T. T. , Gordon Anne D. , Flory Michael J. , Parab Santosh M. , Tsai Chia-Ling 
Published: July 2023

Abstract
Background
Very preterm infants are at elevated risk for neurodevelopmental delays. Earlier prediction of delays allows timelier intervention and improved outcomes. Machine learning (ML) was used to predict mental and psychomotor delay at 25 months.

Methods
We applied RandomForest classifier to data from 1109 very preterm infants recruited over 20 years. ML selected key predictors from 52 perinatal and 16 longitudinal variables (1–22 mo assessments). SHapley Additive exPlanations provided model interpretability.

Results
Balanced accuracy with perinatal variables was 62%/61% (mental/psychomotor). Top predictors of mental and psychomotor delay overlapped and included: birth year, days in hospital, antenatal MgSO4, days intubated, birth weight, abnormal cranial ultrasound, gestational age, mom’s age and education, and intrauterine growth restriction. Highest balanced accuracy was achieved with 19-month follow-up scores and perinatal variables (72%/73%).

Conclusions
Combining perinatal and longitudinal data, ML modeling predicted 24 month mental/psychomotor delay in very preterm infants ½ year early, allowing intervention to start that much sooner. Modeling using only perinatal features fell short of clinical application. Birth year’s importance reflected a linear decline in predicting delay as birth year became more recent.

Impact

Combining perinatal and longitudinal data, ML modeling was able to predict 24 month mental/psychomotor delay in very preterm infants ½ year early (25% of their lives) potentially advancing implementation of intervention services.

Although cognitive/verbal and fine/gross motor delays require separate interventions, in very preterm infants there is substantial overlap in the risk factors that can be used to predict these delays.

Birth year has an important effect on ML prediction of delay in very preterm infants, with those born more recently (1989–2009) being increasing less likely to be delayed, perhaps reflecting advances in medical practice.
Loss of TP53 cooperates with c-MET overexpression to drive hepatocarcinogenesis
Authors: Zhou Yi , Cui Guofei , Xu Hongwei , Chun Joanne , Yang Doris , Zhang Zheng , Yang Lihui , Wang Jingxiao , Wan Meijuan , Calvisi Diego F. , Lin Shumei , Chen Xin , Wang Haichuan 
Published: July 2023

AbstractHepatocellular carcinoma (HCC) is a deadly malignancy with high genetic heterogeneity. TP53 mutation and c-MET activation are frequent events in human HCCs. Here, we discovered that the simultaneous mutations in TP53 and activation of c-MET occur in ~20% of human HCCs, and these patients show a poor prognosis. Importantly, we found that concomitant deletion of Trp53 and overexpression of c-MET (c-MET/sgp53) in the mouse liver led to HCC formation in vivo. Consistent with human HCCs, RNAseq showed that c-MET/sgp53 mouse HCCs were characterized by activated c-MET and Ras/MAPK cascades and increased tumor cell proliferation. Subsequently, a stably passaged cell line derived from a c-MET/sgp53 HCC and corresponding subcutaneous xenografts were generated. Also, in silico analysis suggested that the MEK inhibitor trametinib has a higher inhibition score in TP53 null human HCC cell lines, which was validated experimentally. We consistently found that trametinib effectively inhibited the growth of c-MET/sgp53 HCC cells and xenografts, supporting the possible usefulness of this drug for treating human HCCs with TP53-null mutations. Altogether, our study demonstrates that loss of TP53 cooperates with c-MET to drive hepatocarcinogenesis in vivo. The c-MET/sgp53 mouse model and derived HCC cell lines represent novel and useful preclinical tools to study hepatocarcinogenesis in the TP53 null background.
A small molecule inhibitor of PTP1B and PTPN2 enhances T cell anti-tumor immunity
Authors: Liang Shuwei , Tran Eric , Du Xin , Dong Jiajun , Sudholz Harrison , Chen Hao , Qu Zihan , Huntington Nicholas D. , Babon Jeffrey J. , Kershaw Nadia J. , Zhang Zhong-Yin , Baell Jonathan B. , Wiede Florian , Tiganis Tony 
Published: July 2023

AbstractThe inhibition of protein tyrosine phosphatases 1B (PTP1B) and N2 (PTPN2) has emerged as an exciting approach for bolstering T cell anti-tumor immunity. ABBV-CLS-484 is a PTP1B/PTPN2 inhibitor in clinical trials for solid tumors. Here we have explored the therapeutic potential of a related small-molecule-inhibitor, Compound-182. We demonstrate that Compound-182 is a highly potent and selective active site competitive inhibitor of PTP1B and PTPN2 that enhances T cell recruitment and activation and represses the growth of tumors in mice, without promoting overt immune-related toxicities. The enhanced anti-tumor immunity in immunogenic tumors can be ascribed to the inhibition of PTP1B/PTPN2 in T cells, whereas in cold tumors, Compound-182 elicited direct effects on both tumor cells and T cells. Importantly, treatment with Compound-182 rendered otherwise resistant tumors sensitive to α-PD-1 therapy. Our findings establish the potential for small molecule inhibitors of PTP1B and PTPN2 to enhance anti-tumor immunity and combat cancer.
Increasing number of long-lived ancestors marks a decade of healthspan extension and healthier metabolomics profiles
Authors: van den Berg Niels , Rodríguez-Girondo Mar , van Dijk Ingrid K. , Slagboom P. Eline , Beekman Marian 
Published: July 2023

AbstractGlobally, the lifespan of populations increases but the healthspan is lagging behind. Previous research showed that survival into extreme ages (longevity) clusters in families as illustrated by the increasing lifespan of study participants with each additional long-lived family member. Here we investigate whether the healthspan in such families follows a similar quantitative pattern using three-generational data from two databases, LLS (Netherlands), and SEDD (Sweden). We study healthspan in 2143 families containing index persons with 26 follow-up years and two ancestral generations, comprising 17,539 persons. Our results provide strong evidence that an increasing number of long-lived ancestors associates with up to a decade of healthspan extension. Further evidence indicates that members of long-lived families have a delayed onset of medication use, multimorbidity and, in mid-life, healthier metabolomic profiles than their partners. We conclude that both lifespan and healthspan are quantitatively linked to ancestral longevity, making family data invaluable to identify protective mechanisms of multimorbidity.
Meis1 establishes the pre-hemogenic endothelial state prior to Runx1 expression
Authors: Coulombe Patrick , Cole Grace , Fentiman Amanda , Parker Jeremy D. K. , Yung Eric , Bilenky Misha , Degefie Lemlem , Lac Patrick , Ling Maggie Y. M. , Tam Derek , Humphries R. Keith , Karsan Aly 
Published: July 2023

AbstractHematopoietic stem and progenitor cells (HSPCs) originate from an endothelial-to-hematopoietic transition (EHT) during embryogenesis. Characterization of early hemogenic endothelial (HE) cells is required to understand what drives hemogenic specification and to accurately define cells capable of undergoing EHT. Using Cellular Indexing of Transcriptomes and Epitopes by Sequencing (CITE-seq), we define the early subpopulation of pre-HE cells based on both surface markers and transcriptomes. We identify the transcription factor Meis1 as an essential regulator of hemogenic cell specification in the embryo prior to Runx1 expression. Meis1 is expressed at the earliest stages of EHT and distinguishes pre-HE cells primed towards the hemogenic trajectory from the arterial endothelial cells that continue towards a vascular fate. Endothelial-specific deletion of Meis1 impairs the formation of functional Runx1-expressing HE which significantly impedes the emergence of pre-HSPC via EHT. Our findings implicate Meis1 in a critical fate-determining step for establishing EHT potential in endothelial cells.
Determinants of sustained stabilization of beta-cell function following short-term insulin therapy in type 2 diabetes
Authors: Retnakaran Ravi , Pu Jiajie , Emery Alexandra , Harris Stewart B. , Reichert Sonja M. , Gerstein Hertzel C. , McInnes Natalia , Kramer Caroline K. , Zinman Bernard 
Published: July 2023

AbstractIn early type 2 diabetes, the strategy of “induction” with short-term intensive insulin therapy followed by “maintenance” with metformin can stabilize pancreatic beta-cell function in some patients but not others. We thus sought to elucidate determinants of sustained stabilization of beta-cell function. In this secondary analysis of ClinicalTrials.Gov NCT02192424, adults with ≤5-years diabetes duration were randomized to 3-weeks induction insulin therapy (glargine/lispro) followed by metformin maintenance either with or without intermittent 2-week courses of insulin every 3-months for 2-years. Sustained stabilization (higher beta-cell function at 2-years than at baseline) was achieved in 55 of 99 participants. Independent predictors of sustained stabilization were the change in beta-cell function during induction and changes in hepatic insulin resistance and alanine aminotransferase during maintenance. Thus, initial reversibility of beta-cell dysfunction during induction and subsequent preservation of hepatic insulin sensitivity during maintenance are associated with sustained stabilization of beta-cell function following short-term insulin and metformin.ClinicalTrials.Gov NCT02192424
Enabling pathways for sustainable livelihoods in planned relocation
Authors: Bower Erica R. , Badamikar Anvesh , Wong-Parodi Gabrielle , Field Christopher B. 
Published: July 2023

AbstractThe planned relocation of entire communities to less hazard-exposed destinations is an increasingly salient climate change adaptation strategy but often results in maladaptive livelihood outcomes. There needs to be understanding of how planning decisions affect outcomes—relocated people’s access to sustainable livelihoods, including physical, economic, natural, human, social and cultural assets. Here, drawing on data from 14 completed flood-related relocation cases, we use fuzzy-set qualitative comparative analysis and find that planning decisions, alone and taken together, contributed to sustainable livelihood outcomes. Relocation processes initiated and driven by community members had better outcomes than government-driven processes, adding a global comparative perspective to prior findings. Speed and transfer dynamics were also critical, with different implications for small and large communities. As a result, multiple pathways of planning decisions can lead to better outcomes, highlighting potential entry points for policy to promote more sustainable and people-centred planned relocation.
Greengenes2 unifies microbial data in a single reference tree
Authors: McDonald Daniel , Jiang Yueyu , Balaban Metin , Cantrell Kalen , Zhu Qiyun , Gonzalez Antonio , Morton James T. , Nicolaou Giorgia , Parks Donovan H. , Karst Søren M. , Albertsen Mads , Hugenholtz Philip , DeSantis Todd , Song Se Jin , Bartko Andrew , Havulinna Aki S. , Jousilahti Pekka , Cheng Susan , Inouye Michael , Niiranen Teemu , Jain Mohit , Salomaa Veikko , Lahti Leo , Mirarab Siavash , Knight Rob 
Published: July 2023

AbstractStudies using 16S rRNA and shotgun metagenomics typically yield different results, usually attributed to PCR amplification biases. We introduce Greengenes2, a reference tree that unifies genomic and 16S rRNA databases in a consistent, integrated resource. By inserting sequences into a whole-genome phylogeny, we show that 16S rRNA and shotgun metagenomic data generated from the same samples agree in principal coordinates space, taxonomy and phenotype effect size when analyzed with the same tree.
Sustainable development of an effective anti-corrosion film over the St12-steel surface against seawater attacks using Ce(III) ions/tri-sodium phosphate anions
Authors: Bahremand Farshad , Shahrabi Taghi , Ramezanzadeh Bahram , Hosseini Seyed Ali 
Published: July 2023

AbstractOne application of organic compounds is to utilize them as corrosion inhibitors in acidic environments to diminish steel corrosion. These inhibitors do not show very good inhibition properties in saline (NaCl) environments. There have been many studies on boosting these inhibitors’ performance in such environments (especially Cl− containing media). One of the ways that have been proposed is the use of organic and inorganic inhibitors, simultaneously. The synergistic effect of these inhibitors has shown promising results in reducing steel corrosion. In this study, cerium(III) nitrate and tri-sodium phosphate (TSP) was used as organic and inorganic inhibitors to control the corrosion of steel in a 3.5 wt.% NaCl environment. The corrosion measurements were conducted in the 3.5 wt.% NaCl environment by EIS and polarization methods. Surface studies were done by SEM, Raman, GIXRD, and EDS methods. Corrosion studies (EIS and polarization) have revealed that when 500 ppm of Ce(NO3)3 and 500 ppm of TSP are added to the 3.5 wt.% NaCl medium, the highest synergism index (1.27) and inhibition efficiency (73.7%) are achieved. Also, by adding 500Ce-500TPS to the solution, icorr and Rct of steel decreased by about 80% and increased approximately 4-fold, respectively. This improvement in the steel performance against corrosion in the presence of an equal ratio of Ce(NO3)3 and TSP is the outcome of the formation of a hydrophobic dense film (consisting of Ce(OH)3, Ce/Fe-phosphate complexes) on the metal surface. This claim has been proven by SEM/EDS, contact angel, FT-IR, and XRD analysis.
Identification and verification of potential biomarkers in sertoli cell-only syndrome via bioinformatics analysis
Authors: Jiang Yuting , Yang Xiao , Li Linlin , Lv Xin , Wang Ruixue , Zhang Hongguo , Liu Ruizhi 
Published: July 2023

AbstractSertoli cell-only syndrome (SCOS), a severe testicular spermatogenic failure, is characterized by total absence of male germ cells. To better expand the understanding of the potential molecular mechanisms of SCOS, we used microarray datasets from the Gene Expression Omnibus (GEO) and ArrayExpress databases to determine the differentially expressed genes (DEGs). In addition, functional enrichment analysis including the Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) was performed. Protein–protein interaction (PPI) networks, modules, and miRNA-mRNA regulatory networks were constructed and analyzed and the validation of hub genes was performed. A total of 601 shared DEGs were identified, including 416 down-regulated and 185 up-regulated genes. The findings of the enrichment analysis indicated that the shared DEGs were mostly enriched in sexual reproduction, reproductive process, male gamete generation, immune response, and immunity-related pathways. In addition, six hub genes (CCNA2, CCNB2, TOP2A, CDC20, BUB1, and BUB1B) were selected from the PPI network by using the cytoHubba and MCODE plug-ins. The expression levels of the hub genes were significantly decreased in patients with SCOS compared to that in normal spermatogenesis controls as indicated by the microarray data, single-cell transcriptomic data, and clinical sample levels. Furthermore, the potential miRNAs were predicted via the miRNA-mRNA network construction. These hub genes and miRNAs can be used as potential biomarkers that may be related to SCOS. However, it has not been proven that the differential expression of these biomarkers is the molecular pathogenesis mechanisms of SCOS. Our findings suggest that these biomarkers can be serve as clinical tool for diagnosis targets and may have some impact on the spermatogenesis of SCOS from a testicular germ cell perspective.
Dietary aflatoxin B1 and antimalarial—a lumefantrine/artesunate—therapy perturbs male rat reproductive function via pro-inflammatory and oxidative mechanisms
Authors: Owumi Solomon E. , Umez Angel O. , Arunsi Uche , Irozuru Chioma E. 
Published: July 2023

AbstractWe investigated the impact of Coartem™ (COA) and aflatoxin B1 (AFB1) on rats’ hypothalamus, epididymis, and testis. Male rats were randomly grouped (n = 5 rats) and treated: control group (corn oil), AFB1(70 µg/kg), COA (5 mg/kg), COA + AFB1(5 + 0.035 mg/kg) and COA + AFB1(5 + 0.07 mg/kg) for 28 days. Blood samples were collected for serum prolactin, testosterone, follicle-stimulating and luteinising hormones (FSH and LH) assay upon sacrifice. The semen, hypothalamus, epididymis, and testes were harvested for morphological, biochemical, and histopathology determination of oxidative, inflammation stress, genomic integrity, and pathological alterations. Exposure to the COA and AFB1caused the cauda epididymal spermatozoa to display low motility, viability, and volume, with increased abnormalities. Hormonal disruption ensued in animals exposed to COA and AFB1alone or together, exemplified by increased prolactin, and decreased testosterone, FSH and LH levels. Treatment-related reduction in biomarkers of testicular metabolism—acid and alkaline phosphatases, glucose-6-phosphate dehydrogenase, and lactate dehydrogenase—were observed. Also, COA and AFB1treatment caused reductions in antioxidant (Glutathione and total thiols) levels and antioxidant enzyme (Catalase, superoxide dismutase, glutathione peroxidase, and glutathione-S-transferase) activities in the examined organs. At the same time, treatment-related increases in DNA damage (p53), oxidative stress (xanthine oxidase, reactive oxygen and nitrogen species and lipid peroxidation), inflammation (nitric oxide and tumour necrosis factor-alpha), and apoptosis (caspase-9, and -3) were observed. Chronic exposure to COA and AFB1 led to oxidative stress, inflammation, and DNA damage in male rats' hypothalamic-reproductive axis, which might potentiate infertility if not contained.