bluuebunny/crossref_metadata_2025_split huggingface dataset:
Accessing Azetidines through Magnesium‐Mediated Nitrogen Group Transfer from Iminoiodinane to Donor‐Acceptor Cyclopropanes
Authors: Bansode Ajay H. , Yin Lifeng , Deng Ning , Afrasi Mahmoud , Zhu Yiyi , Parasram Marvin 
Published: January 2025

AbstractHerein, we report a Lewis acid‐mediated ring expansion of donor‐acceptor cyclopropanes (DACs) to substituted azetidines via nucleophilic nitrogen group transfer from readily accessible iminoiodinane. This protocol operates under mild, transition‐metal‐free conditions, and showcases excellent chemoselectivity, along with broad functional group tolerance. We report for the first time that challenging alkyl donor‐acceptor cyclopropanes can undergo ring expansion leading to aliphatic azetidines without relying on external oxidants or precious transition‐metal catalysts. Mechanistically, the coordination of a magnesium (Mg)‐Lewis acid to the DAC promotes nucleophilic ring opening with a putative Mg‐amide species generated from the iminoiodinane under the reaction conditions to furnish the azetidine products.
Right atrial and ventricular clot as a cause of peri‐arrest during caesarean birth requiring immediate thrombectomy
Authors: Golan A. , Azem K. , Gogol A. , Weiss L. , Gorfil D. , Fein S. , Orbach‐Zinger S. 
Published: January 2025

SummaryVenous thromboembolic disease remains a leading cause of maternal morbidity and mortality. We report a case of a 30‐year‐old woman at 37+6 gestation with a history of thalassaemia intermedia and splenectomy. During pregnancy, she had been managed with frequent blood transfusions and enoxaparin. She was admitted for induction of labour, and during labour, she developed pre‐eclampsia with severe features. Despite magnesium sulphate therapy, she had a short self‐terminating seizure shortly after an epidural had been sited. A decision to proceed with an urgent caesarean birth under epidural anaesthesia was made. After birth, she had another seizure associated with oxygen desaturation. Bag‐valve‐mask ventilation was insufficient, prompting conversion to general anaesthesia and tracheal intubation, after which cardiac collapse developed. Resuscitation was initiated and bedside cardiac ultrasound revealed a large clot‐in‐transit through the right atrium and ventricle, prompting immediate transfer to cardiac theatres for thrombectomy. The thrombus was successfully removed. The patient recovered well and her trachea was extubated the next day. She was discharged in a stable condition 8 days later. This case highlights the critical role of point‐of‐care ultrasound in the prompt diagnosis of life‐threatening conditions and guiding emergency interventions.
A Copper Sulfide Doped 2D‐MXene‐Based Ultrasensitive Label‐Free Electrochemical Immunosensor for EpCAM Antigen Detection
Authors: Sweety  , Paneru Saroj , Kumar Devendra 
Published: January 2025

ABSTRACTHerein, a novel CuS‐anchored 2D‐Ti3C2Tx composite material was synthesized by a one‐pot hydrothermal method. This CuS/Ti3C2Tx hybrid was used to prepare a novel label‐free electrochemical immunosensor for EpCAM antigen detection. The immunosensor has been fabricated by electrophoretic deposition of CuS/Ti3C2Tx hybrid onto the ITO electrode followed by the immobilization of anti‐EpCAM. The electrochemical biosensing studies of this fabricated immunosensor, BSA/anti‐EpCAM/CuS/Ti3C2Tx@ITO demonstrated a wide linear range (0.01 fg/mL to 100 ng/mL) and low LOD (0.0057 fg/mL), together with high sensitivity (461.85 μA fg−1 mL cm−2) for EpCAM antigen detection. The clinical validation of the proposed immunosensor was conducted with serum samples. Moreover, the immunosensor was found to be reproducible, specific, selective, and stable over a long period of 42 days.
Chaotic fun! Promoting active recall of anatomical structures and relationships using the Catch‐Phrase game
Authors: Cale Andrew S. , McNulty Margaret A. 
Published: January 2025

AbstractActive recall, the act of recalling knowledge from memory, and games‐based learning, the use of games and game elements for learning, are well‐established as effective strategies for learning gross anatomy. An activity that applies both principles is Catch‐Phrase, a fast‐paced word guessing game. In Anatomy Catch‐Phrase, players must get their teammates to identify an anatomical term by describing its features, functions, or relationships without saying the term itself. Once a teammate guesses the term, players switch roles and continue play with the next term(s) until time runs out. Meanwhile, the instructor notes common errors and reviews knowledge gaps with the team at the end of the round. Prior to the first exam, a seven‐question evaluation was distributed to the health professional students. A total of 18 dissection lab groups (86%) played one round of Anatomy Catch‐Phrase, with many groups playing multiple times. After the first exam, 73 students (61%) completed the evaluation. On a five‐point scale, most students indicated they enjoyed Anatomy Catch‐Phrase (4.3 ± 0.9), highly recommended it (4.2 ± 0.9), and wanted to play it in the future (4.3 ± 1.0). Most students also found the game relevant to the course material (4.5 ± 0.8), useful for reviewing (3.9 ± 0.9), and helped reinforce their knowledge (3.9 ± 0.9). Anatomy Catch‐Phrase was highly rated, with a score of 4.3 ± 0.9. Multiple students also provided enthusiastic unsolicited comments, such as ‘LOVED IT! A fun way to study anatomy!:)’. Overall, Anatomy Catch‐Phrase was well‐received as a fun activity for reviewing the anatomy relevant to the course.
Development and Validation of a Green Spectrofluorimetric Method for Nateglinide Quantification: Utilizing AR87 as a Probe With Box–Behnken Optimization and Quantum Mechanical Calculations
Authors: Alqahtani Ali , Alqahtani Taha , Alshehri Adil , Almrasy Ahmed A. 
Published: January 2025

ABSTRACTIn this study, a sensitive and selective spectrofluorimetric method was developed for the determination of the antidiabetic drug nateglinide based on its reaction with the xanthene dye acid red 87 (AR87). A fluorescence quenching process was observed for the AR87 at 545 nm upon the addition of nateglinide, which was exploited for the quantitative analysis. The reaction mechanism was investigated using quantum mechanical calculations suggesting a transfer between the electron‐rich AR87 and the electron‐deficient nateglinide. Additionally, the stoichiometry of the interaction was determined through Job's method revealing a 1:1 nateglinide–AR87 complex formation. The experimental parameters were optimized using a Box–Behnken design of experiments, including pH, reagent concentration, and buffer volume. The optimized method was validated according to ICH guidelines, demonstrating excellent linearity in the range of 0.1–3.0 μg/mL, with a detection limit of 0.0320 μg/mL and a quantitation limit of 0.0961 μg/mL. Furthermore, the greenness and blueness of the method were assessed using the AGREE and BAGI indices, indicating an environmentally friendly procedure. The developed method was successfully applied for the determination of nateglinide in pharmaceutical dosage forms and spiked human plasma samples posing a promising analytical tool for clinical and quality control applications.
Can Large Language Models Aid Caregivers of Pediatric Cancer Patients in Information Seeking? A Cross‐Sectional Investigation
Authors: Sezgin Emre , Jackson Daniel I. , Kocaballi A. Baki , Bibart Mindy , Zupanec Sue , Landier Wendy , Audino Anthony , Ranalli Mark , Skeens Micah 
Published: January 2025

ABSTRACTPurposeCaregivers in pediatric oncology need accurate and understandable information about their child's condition, treatment, and side effects. This study assesses the performance of publicly accessible large language model (LLM)‐supported tools in providing valuable and reliable information to caregivers of children with cancer.MethodsIn this cross‐sectional study, we evaluated the performance of the four LLM‐supported tools—ChatGPT (GPT‐4), Google Bard (Gemini Pro), Microsoft Bing Chat, and Google SGE—against a set of frequently asked questions (FAQs) derived from the Children's Oncology Group Family Handbook and expert input (In total, 26 FAQs and 104 generated responses). Five pediatric oncology experts assessed the generated LLM responses using measures including accuracy, clarity, inclusivity, completeness, clinical utility, and overall rating. Additionally, the content quality was evaluated including readability, AI disclosure, source credibility, resource matching, and content originality. We used descriptive analysis and statistical tests including Shapiro–Wilk, Levene's, Kruskal–Wallis H‐tests, and Dunn's post hoc tests for pairwise comparisons.ResultsChatGPT shows high overall performance when evaluated by the experts. Bard also performed well, especially in accuracy and clarity of the responses, whereas Bing Chat and Google SGE had lower overall scores. Regarding the disclosure of responses being generated by AI, it was observed less frequently in ChatGPT responses, which may have affected the clarity of responses, whereas Bard maintained a balance between AI disclosure and response clarity. Google SGE generated the most readable responses whereas ChatGPT answered with the most complexity. LLM tools varied significantly (p < 0.001) across all expert evaluations except inclusivity. Through our thematic analysis of expert free‐text comments, emotional tone and empathy emerged as a unique theme with mixed feedback on expectations from AI to be empathetic.ConclusionLLM‐supported tools can enhance caregivers' knowledge of pediatric oncology. Each model has unique strengths and areas for improvement, indicating the need for careful selection based on specific clinical contexts. Further research is required to explore their application in other medical specialties and patient demographics, assessing broader applicability and long‐term impacts.
Disability‐Adjusted Life Years (DALYs) due to Breast, Cervical, Colorectal and Oral Cancers in Taiwan Regions
Authors: Hsieh Cheng‐Chieh , Chen Si‐Yu , Lin Chun‐Hui , Chen Szu‐Chieh , Liao Chung‐Min 
Published: January 2025

ABSTRACTBackgroundCancer is a leading cause of death globally, with significant variations in incidence and mortality rates among different cancer types and regions. In Taiwan, breast cancer (BC), cervical cancer (CxCa), colorectal cancer (CRC), and oral cancer (OC) are prevalent and have prompted government‐led screening programs to mitigate their impact. This study aims to assess the burden of these cancers at the county scale using disability‐adjusted life years (DALYs) as a metric, focusing on the years 2010, 2015, 2018, 2019, and 2020.MethodsData on cancer incidence, mortality, disability weights, and treatment outcomes were sourced from the Taiwan HPA, Ministry of Health and Welfare, and Taiwan Cancer Registry. Years of life lost (YLLs) and years lived with disability (YLDs) were calculated for each cancer, considering age, stage, and treatment. The correlation between cancer screening rates and disease burden also conducted.ResultsThe analysis highlights significant trends in cancer mortality, incidence, and disease burden in Taiwan from 2010 to 2020. BC and CRC showed rising ASMR and DALYs rates, while CxCa experienced consistent declines. OC had a fluctuating pattern, particularly in eastern regions. YLLs contributed significantly to DALYs for all cancers, emphasizing premature mortality's role in the disease burden. Screening rates, particularly for BC and CxCa, correlated with changes in burden, with BC rates increasing and CxCa decreasing, reflecting the impact of preventive measures on cancer outcomes.ConclusionsThe findings underscore the importance of targeted interventions and evidence‐informed resource allocation to address regional differences in cancer burden in Taiwan.
Health Situation Among Women Experiencing Homelessness Who Have Been Involved in Prostitution
Authors: González‐Arribas Olga , Panadero Sonia , Torrego Silvia , Vázquez José Juan 
Published: January 2025

ABSTRACTPeople in a homeless situation are one of the most obvious embodiments of the phenomenon of social exclusion, and women living homeless are a particularly vulnerable group. The article analyses the differences in health status between women experiencing homelessness who have been involved in prostitution and those who have not. The sample consisted of 135 women experiencing homelessness in Madrid, Spain. From the total sample interviewed, 81% had never been involved in prostitution, while 19% had been in this situation at some point in their lives. The results obtained show that women experiencing homelessness who have been involved in prostitution had poorer health outcomes, with a higher prevalence of diagnosed serious or chronic illnesses and more mental health problems, compared to women experiencing homelessness who had not been involved in prostitution. Considering that health problems most severely affect women experiencing homelessness who have also been involved in prostitution, it seems necessary to design and implement public policies and intervention programmes with a gender‐sensitive approach that are accessible to women in situations of extreme vulnerability.
Served or Exploited: The Impact of Data Capture Strategy on Users' Intention to Use Selected AI Systems
Authors: Liu Xianggang , Shi Zhanzhong 
Published: January 2025

ABSTRACTIn the era of digital intelligence, companies need to capture more data to portray the user profile to “grab” the “heart” of the consumer, AI is undoubtedly a powerful tool to implement this process. Nevertheless, it has also gradually sparked concerns regarding user privacy and data. Recent studies have increasingly focused on user reactions to AI data capture, yet exploration in this area remains limited. This research contributes to the existing literature by investigating the underlying psychological processes and influencing factors that prompt users to confront AI data capture. Through four studies, we found the data capture strategies have a significant negative impact on users' intention to use AI systems, and compared with the overt data capture strategy, the covert strategy would make users' intention to use AI systems lower. The impact is mediated by psychological ownership, specifically, it is mediated by perceived control of psychological ownership rather than perceived possession. Additionally, prevention‐oriented users are more likely to feel deprived of their right to be informed and their control over data. However, AI explainability can increase users' psychological ownership and intention to use by alleviating their psychological defenses in the process. These results are conducive to promoting the resolution of AI data governance issues under digital intelligence empowerment, and providing a reference for reasonable strategies adopted by enterprises in using AI data capture.
Hemorrhagic Longitudinally Extensive Transverse Myelitis (LETM) as a First Presentation of Neuromyelitis Optica Spectrum Disorder (NMOSD): A Case Report and Literature Review
Authors: Jahani Shima , Jamshidi Fateme , Moghadasi Abdorreza Naser 
Published: January 2025

ABSTRACTHere we present a rare case of hemorrhagic longitudinally extensive transverse myelitis (LETM) as a first presentation of Neuromyelitis Optica Spectrum Disorder. Even though the patient received aggressive treatment, he showed no significant improvement. Our case highlights the importance of prompt intervention in the case of hemorrhagic myelitis and the diagnostic challenges of hemorrhagic LETM.
Review on Synthesis of Ceramic Membranes to Mitigate Membrane Fouling in Oil–Water Separation
Authors: Pujari Murali , Shingan Bhalchandra , Arya Adarsh Kumar , Naga Chaitanya G. 
Published: January 2025

AbstractMembrane‐based separation processes have been gaining significant attention in the treatment of oily wastewater. To date, a remarkable amount of data is available on the application of membranes in diverse domains such as industrial wastewater treatment, food processing, and medicine. It is becoming a severe issue when process sectors like mining, metallurgy, and petrochemicals discharge oily wastewater. Although oil–water emulsion separation using membrane technology is successful, this method suffers from a serious flux declination problem brought on by fouling during filtration. Keeping this in mind, the aim of this paper is to highlight the recent advancements in the synthesis of ceramic membranes from several perspectives such as feed pretreatment, membrane cleaning, proper operational conditions, and the use of antifouling coatings. Recent study has indicated that surface hydrophilization is the key emphasis in mitigating membrane fouling. Thus, the current state of membrane surface modification technology is reviewed, and future trends are identified.
Overcoming the Tradeoff Between Reaction Rate and Overpotential in Dinuclear Cobalt Complex Catalyzed Electrochemical Water Oxidation
Authors: Wang Yu‐Han , Tseng Yun‐Jou , Kumbhar Sharad V. , Chang Hao‐Ting , Yang Tzuhsiung , Lu I‐Chung , Wang Yu‐Heng 
Published: January 2025

AbstractThis study focuses on enhancing the water oxidation reaction (WOR) efficacy of dinuclear cobalt complex catalysts from both kinetic (turnover frequency, TOF) and thermodynamic (overpotential, η) perspectives. For this purpose, we synthesized six dinuclear cobalt complexes 1–6 comprising non‐innocent ligands with different electronically active substituents (−OMe (1), −Me (2), −H (3), −F (4), −Cl (5), and −CN (6)). The electronic effects on the electrochemical WOR under neutral, acidic, and alkaline conditions were investigated experimentally and computationally. X‐ray crystallography revealed that the valence state of the cobalt complexes was affected by electronic effects, affording different catalytic potentials, as evidenced by electrochemical measurements. Kinetic and spectroscopic studies confirmed that the synergistic effect of catalyst identity and reaction media changes the reaction mechanism of each catalyst. The WOR performance of 1–6 was tunable through ligand electronics and solvent effects, with the log(TOF)−η analysis highlighting an operational η as low as 40 mV. This study provides valuable insights into optimizing WOR catalysis through molecular design and environmental tuning.
The miRNA‐mRNA Regulatory Network in Human Hepatocellular Carcinoma by Transcriptomic Analysis From GEO
Authors: Heidari Razieh , Assadollahi Vahideh , Marashi Seyedeh Negar , Elahian Fatemeh , Mirzaei Seyed Abbas 
Published: January 2025

ABSTRACTBackgroundBioinformatics analysis of hepatocellular carcinoma (HCC) expression profiles can aid in understanding its molecular mechanisms and identifying new targets for diagnosis and treatment.AimIn this study, we analyzed expression profile datasets and miRNA expression profiles related to HCC from the GEO using R software to detect differentially expressed genes (DEGs) and differentially expressed miRNAs (DEmiRs).Methods and resultsCommon DEGs were identified, and a PPI network was constructed using the STRING database and Cytoscape software to identify hub genes. The reduced levels of tumor suppressor miRNAs or down regulated DEmiRs may be increased levels of oncogenes, the oncomirs or up regulated DEmiRs may be decreased levels of tumor suppressor genes in cancerous cells. According to this strategy, increased and decreased DEGs, also increased and decreased DEmiRs were selected. The multimir package was employed to predict target genes for DEmiRs then DEmiRs‐hub gene network created. We identified approximately 1000 overlapping DEGs and 60 DEmiRs. Hub genes included RRM2, MELK, KIF11, KIF23, NCAPG, DLGAP5, BUB1B, AURKB, CCNB1, KIF20A, CCNA2, TTK, PBK, TOP2A, CDK1, MAD2L1, BIRC5, ASPM, CDCA8, and CENPF, all associated with significantly worse survival in HCC. miR‐224, miR‐24, miR‐182, miRNA‐1‐3p, miR‐30a, miR‐27a, and miR‐214 were identified as important DEmiRs with targeting more than six hub genes.ConclusionGenerally, our findings offer insight into the interaction of hub genes and miRNAs in the development of HCC by bioinformatics analysis, information that may prove useful in identifying biomarkers and therapeutic targets in HCC.
Pharmacokinetic and Pharmacodynamic Equivalence of Biosimilar and Reference Ultra‐Rapid Lispro: A Comparative Clamp Study in Healthy Volunteers
Authors: Noskov Sergei , Koksharova Ekaterina , Arefeva Anna , Banko Veniamin , Radaeva Kseniia , Matvienko Iuliia , Gefen Maria , Makarenko Igor , Drai Roman 
Published: January 2025

AbstractUltra‐rapid insulin lispro is an innovative insulin analogue designed to achieve rapid onset and short duration of action, aimed at optimizing glycemic control in patients with diabetes. This was a double‐blind, randomized, 2‐period, crossover clamp study to evaluate the pharmacokinetics (PK) and pharmacodynamics (PD), along with safety profiles, of a potential biosimilar ultra‐rapid insulin lispro compared to the reference product in healthy White men. A total of 35 healthy volunteers completed hyperinsulinemic euglycemic clamp procedures across both study periods. Blood samples were collected at predefined intervals up to 8 hours to assess PK parameters. Plasma glucose levels were monitored every 5 minutes during the 8‐hour clamps, with adjustments to the glucose infusion rate to maintain the target range. Insulin quantification in plasma was conducted using a validated enzyme‐linked immunosorbent assay method. PD assessment was based on glucose infusion rate profiles during both clamps. Geometric mean ratios for maximum plasma concentration and area under the concentration‐time curve from insulin administration to the last measurable concentration for the test and reference drugs fell within the bioequivalence range of 80%‐125%. Furthermore, the investigational drugs demonstrated comparable PK/PD profiles of insulin lispro. Both formulations exhibited similar safety profiles primarily characterized by mild injection site reactions.
Towards Recycling of All‐Solid‐State Batteries with Argyrodite Sulfide Electrolytes: Insights into Electrolyte and Electrode Degradation in Dissolution‐Based Separation Processes
Authors: Wissel Kerstin , Hu Zian , Wu Xuebin , Jacob Martine , Küster Kathrin , Starke Ulrich , Clemens Oliver 
Published: January 2025

AbstractAll‐solid‐state Li‐ion batteries (ASSBs) represent a promising leap forward in battery technology, rapidly advancing in development. Among the various solid electrolytes, argyrodite thiophosphates Li6PS5X (X=Cl, Br, I) stand out due to their high ionic conductivity, structural flexibility, and compatibility with a range of electrode materials, making them ideal candidates for efficient and scalable battery applications. However, despite significant performance advancements, the sustainability and recycling of ASSBs remain underexplored, posing a critical challenge for achieving efficient circular processes. This study investigates the dissolution‐based separation and recovery of argyrodite thiophosphate electrolytes and transition metal oxide electrode materials as a potential recycling strategy for ASSBs. A focus is set on the impact of solvent treatments on the recrystallization behavior of these electrolytes. Furthermore, the interactions between dissolved argyrodite thiophosphates and various transition metal oxide electrode materials (LiCoO2, LiMn2O4, LiNi0.8Mn0.1Co0.1O2, LiFePO4 and Li4Ti5O12) is examined to assess their influence on the functional properties of both the electrolytes and electrode materials. Structural, compositional and morphological changes are analyzed using X‐ray diffraction, scanning electron microscopy, energy‐dispersive X‐ray spectroscopy, inductively coupled plasma mass spectrometry and X‐ray photoelectron spectroscopy. Our findings provide insights into the complexities of recycling ASSBs, but also highlight the potential for developing efficient, sustainable recycling processes.