bluuebunny/crossref_metadata_2025_split huggingface dataset:
Myocardial Milieu Favors Local Differentiation of Regulatory T Cells
Authors: Delgobo Murilo , Weiß Emil , Ashour DiyaaElDin , Richter Leon , Popiolkowski Lisa , Arampatzi Panagiota , Stangl Verena , Arias-Loza Paula , Mariotti-Ferrandiz Encarnita , Rainer Peter P. , Saliba Antoine-Emmanuel , Ludewig Burkhard , Hofmann Ulrich , Frantz Stefan , Campos Ramos Gustavo 
Published: February 2023

Background:
In the past years, several studies investigated how distinct immune cell subsets affects post–myocardial infarction repair. However, whether and how the tissue environment controls these local immune responses has remained poorly understood. We sought to investigate how antigen-specific T-helper cells differentiate under myocardial milieu’s influence.

Methods:

We used a transgenic T cell receptor (TCR-M) model and major histocompatibility complex-II tetramers, both myosin-specific, combined with single-cell transcriptomics (single-cell RNA sequencing [scRNA-seq]) and functional phenotyping to elucidate how the antigen-specific CD4
+
T cells differentiate in the murine infarcted myocardium and influence tissue repair. Additionally, we transferred proinflammatory versus regulatory predifferentiated TCR-M-cells to dissect how they specially contribute to post–myocardial infarction inflammation.

Results:

Flow cytometry and scRNA-/TCR-seq analyses revealed that transferred TCR-M cells acquired an induced regulatory phenotype (induced regulatory T cell) in the infarcted myocardium and blunted local inflammation. Myocardial TCR-M cells differentiated into 2 main lineages enriched with either cell activation and profibrotic transcripts (eg,
Tgfb1
) or suppressor immune checkpoints (eg,
Pdcd1
), which we also found in human myocardial tissue. These cells produced high levels of LAP (latency-associated peptide) and inhibited IL-17 (interleukin-17) responses. Endogenous myosin-specific T-helper cells, identified using genetically barcoded tetramers, also accumulated in infarcted hearts and exhibited a regulatory phenotype. Notably, TCR-M cells that were predifferentiated toward a regulatory phenotype in vitro maintained stable in vivo FOXP3 (Forkhead box P3) expression and anti-inflammatory activity whereas T
H
17 partially converted toward a regulatory phenotype in the injured myocardium. Overall, the myosin-specific Tregs dampened post–myocardial infarction inflammation, suppressed neighboring T cells, and were associated with improved cardiac function.

Conclusions:
These findings provide novel evidence that the heart and its draining lymph nodes actively shape local immune responses by promoting the differentiation of antigen-specific Tregs poised with suppressive function.
Application of Magnetocardiography to Screen for Inflammatory Cardiomyopathy and Monitor Treatment Response
Authors: Brala Debora , Thevathasan Tharusan , Grahl Simon , Barrow Steve , Violano Michele , Bergs Hendrikje , Golpour Ainoosh , Suwalski Phillip , Poller Wolfgang , Skurk Carsten , Landmesser Ulf , Heidecker Bettina 
Published: February 2023

Background
Inflammatory cardiomyopathy is one of the most common causes of sudden cardiac death in young adults. Diagnosis of inflammatory cardiomyopathy remains challenging, and better monitoring tools are needed. We present magnetocardiography as a method to diagnose myocardial inflammation and monitor treatment response.

Methods and Results
A total of 233 patients were enrolled, with a mean age of 45 (±18) years, and 105 (45%) were women. The primary analysis included 209 adult subjects, of whom 66 (32%) were diagnosed with inflammatory cardiomyopathy, 17 (8%) were diagnosed with cardiac amyloidosis, and 35 (17%) were diagnosed with other types of nonischemic cardiomyopathy; 91 (44%) did not have cardiomyopathy. The second analysis included 13 patients with inflammatory cardiomyopathy who underwent immunosuppressive therapy after baseline magnetocardiography measurement. Finally, diagnostic accuracy of magnetocardiography was tested in 3 independent cohorts (total n=23) and 1 patient, who developed vaccine‐related myocarditis.

First, we identified a magnetocardiography vector to differentiate between patients with cardiomyopathy versus patients without cardiomyopathy (vector of ≥0.051; sensitivity, 0.59; specificity, 0.95; positive predictive value, 93%; and negative predictive value, 64%). All patients with inflammatory cardiomyopathy, including a patient with mRNA vaccine‐related myocarditis, had a magnetocardiography vector ≥0.051. Second, we evaluated the ability of the magnetocardiography vector to reflect treatment response. We observed a decrease of the pathologic magnetocardiography vector toward normal in all 13 patients who were clinically improving under immunosuppressive therapy. Magnetocardiography detected treatment response as early as day 7, whereas echocardiographic detection of treatment response occurred after 1 month. The magnetocardiography vector decreased from 0.10 at baseline to 0.07 within 7 days (
P
=0.010) and to 0.03 within 30 days (
P
<0.001). After 30 days, left ventricular ejection fraction improved from 42.2% at baseline to 53.8% (
P
<0.001).

Conclusions
Magnetocardiography has the potential to be used for diagnostic screening and to monitor early treatment response. The method is valuable in inflammatory cardiomyopathy, where there is a major unmet need for early diagnosis and monitoring response to immunosuppressive therapy.
TruthSift: A Platform for Collective Rationality
Authors: Baum Eric B. 
Published: February 2023

AbstractTruthSift is a cloud-based platform that logically combines members’ contributions into a collective intelligence. Members add statements and directed connectors to diagrams. TruthSift monitors which statements have been logically established by demonstrations for which every challenge raised has been refuted by an established refutation. When members run out of rational objections, the result is a converged diagram succinctly representing the state of knowledge about a topic, including plausible challenges and how they were refuted. Previous computer systems for collaborative intelligence did not have a qualitatively better solution for combining contributions than voting and are subject to groupthink, interest group capture, and inability to follow a multistep logical argument. They did not settle issues automatically point by point and logically propagate the consequences. I review indications that many practically important statements most people believe to be firmly established will be revealed to be firmly refuted upon computer-assisted scrutiny. TruthSift also supports construction of powerful probabilistic models over networks of causes, implications, tests, and necessary factors.
Live-Streamed Faith: Diffusion of Live Streaming in the Protestant Church
Authors: Geesaman Ryan A. 
Published: February 2023

Abstract
The coronavirus disease 2019 (covid-19) pandemic and subsequent stay-at-home advisories issued by many states encouraged many houses of worship to begin live streaming or to improve existing capabilities. Even as restrictions on gathering loosened, many people continued to avoid large gatherings out of an abundance of caution, causing many religious institutions to have split congregations: part in person and part virtual. This study examined the motivations and decisions made by U.S.-based Protestant churches of various sizes regarding starting, improving, and continuing live streaming in the face of sudden changes in their ability to reach their congregations. The diffusion of innovations theory was used as a framework to understand how live streaming spread through the Protestant church and how the crisis of the pandemic accelerated that diffusion.
Fighting Religious Extremism with Faith-Based Entertainment-Education: The Portrayal of isis in Arab Drama
Authors: Damanhoury Kareem El 
Published: February 2023

Abstract
isis’s media projected the group’s vision of an Islamic utopia upon declaring its so-called Caliphate in 2014. In response, many counter-messaging campaigns have emerged. Although many examine isis’s media and anti-extremism interventions, very few assess faith-based initiatives in Arab countries. Integrating two bodies of scholarly literature on religious and political conversions and entertainment-education, this study explores al-Siham al-Marika, a faith-based Arab drama portraying life under isis. The study uses mixed-methods to analyze the show’s religious underpinnings, the depiction of positive/negative role models, and the portrayals of religious-political conversions. Focusing on spiritual outcomes, the show illustrates cross-cultural differences in conceptualizing rewards and punishments and uses drama to bolster the persuasive power of religious-political conversion narratives. The study concludes with a discussion on the implications of faith-based entertainment-education in combating extremism and its potential role as a catalyst for bridging the perceived schism between religion and popular culture in some Muslim societies.
Anti-Racist Racism: Trauma, Traumatism, Traumatophilia
Authors: Saketopoulou Avgi 
Published: February 2023

A particular epistemology of trauma now wields an outsized hold over psychoanalysis. Trauma, we are trained to think, has destructive effects whose ghostly lingerings can, nevertheless, be durably turned into ancestors. But what if we got this wrong? What if trauma is not a piece of shrapnel to be removed but a cause of becoming? And what if the tenet that trauma may be worked through is but a manifestation of a disciplinary spell? Introduction of the concept of traumatophobia invites readers to rethink the relationship of psychoanalysis to healing or repair, and to become attentive, instead, to what subjects do with trauma ( traumatophilia). Traumatophilia involves a revivification of trauma, and that is easily confused with compulsive repetition or destructiveness. Traumatophilia, however, also courts psychic energies that can be psychically transformative. For transformation to be possible, however, we need to be working with a notion of psychic life that can be transformed. Careful consideration of a controversial sexual fetish (race play) shows how belated efforts of psychoanalysis to attend to racial trauma have generated new forms of racism: treating the Black unconscious not as a transformative and dynamic force but as housing only repressed representational contents. Considering race play instead through traumatophilia allows a race player’s actions to be mined not for unconscious motives or for what past traumata, symbolized or unformulated, those motives carry, but to track their effects. Traumatophilic repetitions, it is argued, deliver traumatisms that may (or may not) be transformational. Questions of ethics are thus central to this paper’s thinking, which is grounded in queer of color critique, Black feminisms, and Laplanchean metapsychology. Because traumatophobia preserves the world order (and thus white logics), readers are urged to consider the metapsychology of traumatophilia.
Low velocity impact behavior of twill basalt/epoxy composites modified by graphene nanoparticles
Authors: Azimpour-Shishevan Farzin , Mohtadi-Bonab M.A. , Akbulut Hamit , Rahmatinejad Bahman 
Published: February 2023

Nanoparticles are considered as feasible strengthening agent which strengthen different types of polymeric materials with minor reduction in the density of composites. In this study, 0.1 and 0.5 wt. % Graphene Nano Platelets (GNPs) are added to the matrix of basalt fiber reinforced epoxy composites (BECs) and the effects of such addition on low velocity impact behavior are investigated. In this regard, the epoxy matrix is reinforced in macro scale by basalt fibers weaved together in 2/2 Twill pattern. Vacuum Assisted Resin Infusion Molding (VARIM) method is used to fabricate the pure and multi-scale BECs. The profile energy method is also used to evaluate the penetration and perforation threshold of fabricated pure and multi-scale BEC specimens. The force versus time and deflection, energy and deflection versus time curves are plotted and the key parameters of low velocity impact test including maximum force, energy and deflection are compared. According to the results, introducing of GNP nanoparticles in the matrix of BECs improves the low velocity impact behavior of these composites by increasing the contact force and decreasing the absorbed energy in rebounding state. Finally, based on the experiments, the 0.5 wt.% BEC has the best impact performance by applying 15.08 kN impact force against the applied forces of 13.78 kN and 11.208 kN for 0.1 wt.% and pure BECs.
Context and Expectations Matter: Social, Recreational, and Independent Functioning among Youth with Psychosis in Chennai, India and Montreal, Canada
Authors: Iyer Srividya N. , Rangaswamy Thara , Mustafa Sally , Pawliuk Nicole , Mohan Greeshma , Joober Ridha , Schmitz Norbert , Margolese Howard , Padmavati Ramachandran , Malla Ashok 
Published: February 2023

Objectives Most cross-cultural psychosis research has focused on a limited number of outcomes (generally symptom-related) and perspectives (often clinician-/observer-rated). It is unknown if the purported superior outcomes for psychosis in some low- and middle-income countries extend to patient-reported measures of social, recreational, and independent functioning. Addressing this gap, this study aimed to compare these outcomes in first-episode psychosis at a high-income site and a lower middle-income site. Methods Patients receiving similarly designed early intervention for psychosis in Chennai, India ( N = 164) and Montreal, Canada ( N = 140) completed the self-reported Social Functioning Scale-Early Intervention, which measures prosocial, recreation, and independence-performance functioning. Their case managers rated expected independence-performance functioning. Both sets of assessments were done at entry and Months 6, 18, and 24. Linear mixed model analyses of differences between sites and over time were conducted, accounting for other pertinent variables, especially negative symptoms. Results Linear mixed models showed that prosocial, recreation, and independence-performance functioning scores were significantly higher in Montreal than Chennai and did not change over time. Expected independence-performance was also higher in Montreal and increased over time. Negative symptoms and education independently predicted prosocial, recreation, and expected independence-performance functioning. When added to the model, expected independence-performance predicted actual independence-performance and site was no longer significant. At both sites, prosocial and recreation scores were consistently lower (<40%) than independence-performance (40–65%). Conclusion This is the first cross-cultural investigation of prosocial, recreation, and independent functioning in early psychosis. It demonstrates that these outcomes differ by socio-cultural context. Differing levels of expectations about patients, themselves shaped by cultural, illness, and social determinants, may contribute to cross-cultural variations in functional outcomes. At both sites, social, recreational, and independent functioning were in the low-to-moderate range and there was no improvement over time, underscoring the need for effective interventions specifically designed to impact these outcomes.
Racial Disparities in Documented Chief Complaints and Diagnoses in Sepsis Patients
Authors: Liu Helen , McCroskery Stephen , Rajasekaran Vignesh , Linker Anne S , Poeran Jashvant , Truong Tuyet-Trinh 
Published: February 2023

Background Using History and Physical Examination (H&P) notes, we investigated potential racial differences in documented chief complaints and problems among sepsis patients admitted to the intensive care unit. Methods Patient records from Medical Information Mart for Intensive Care (MIMIC-III) dataset indicating a diagnosis of sepsis were included. First recorded clinical notes for each hospital admission were assessed; free text information was specifically extracted on (1) chief complaints, and (2) problems recorded in the Assessment & Plan (A&P) section. The top 10 for each were compared between Black and White patients. Results In initial H&P notes of 17 434 sepsis patients (n = 1229 Black and n = 9806 White), the top 10 most common chief complaints were somewhat similar between Black and White patients. However, relative differences existed in terms of ranking, specifically for altered mental status which was more commonly reported in Black versus White patients (11.7% vs 7.8% P < .001). Among text in the A&P, sepsis was documented significantly less frequently among Black versus White patients: 11.8% versus 14.3%, P = .001. Racial differences were not detected in vital signs and laboratory values. Conclusions This analysis supports the hypothesis that there may be racial differences in early sepsis presentation and possible provider interpretation of these complaints.
Craniosynostosis: Are Online Resources Readable?
Authors: Soliman Luke , Soliman Paul , Gallo Marin Benjamin , Sobti Nikhil , Woo Albert S. 
Published: February 2023

Objective This study aims to analyze the readability of online craniosynostosis materials from the perspective of a caregiver, and to assess if readability levels conform to recommendations by the American Medical Association (AMA) and National Institutes of Health (NIH). Design This is a cross-sectional investigation in which an internet search was conducted simulating the search terms of a caregiver of a patient with craniosynostosis. The first three pages of resulting records were calculated for comprehension ease using validated readability indices. Records were also classified by author type, including hospital system, national health organization, academic journal, and other. Main Outcome Measures Flesch-Kincaid Reading Grade Level, Gunning fog Index, SMOG Index, and Coleman Liau Index. Results Thirty records were identified for which the mean readability level was 12.8 ± 2.6 grade levels (range, 7.6–15.9). There were no significant differences in mean readability across readability indices or author type. None of the thirty records met levels recommended by the AMA or NIH and were 6.8 grade levels above these guidelines on average. Conclusions Online material pertaining to craniosynostosis is written, on average, at the reading level of a first-year undergraduate student. The AMA and NIH recommend that articles be written at approximately a sixth-grade reading level to promote comprehension. Therefore, there is significant room for improvement of current online materials. Authors should consider consulting publicly available guides in preparing future resources.
Patient Satisfaction and Pain Relief After Deep Peroneal Nerve Neurectomy for Midfoot Arthritis: A Preliminary Short Report
Authors: Iturregui Jose M. , Haupt Edward T. , Wilke Benjamin K. , Kraus Jonathan C. , Shi Glenn G. 
Published: February 2023

Background: The deep peroneal nerve (DPN) plays a role in afferent nociceptive dorsal midfoot joint pain perception. DPN neurectomy for treatment of symptomatic dorsal midfoot osteoarthritis allows early mobilization and weightbearing. The purpose of our study was to evaluate the patient satisfaction and pain relief after DPN neurectomy for treatment of chronic dorsal midfoot pain due to osteoarthritis. Methods: In this retrospective, IRB-approved, questionnaire-based study, we evaluated 48 patients (55 feet) with an average follow-up of 35.1 (range, 16-51) months who underwent DPN neurectomy at our institution between September 2017 and February 2021. There were 38 women and 10 men, 41 unilateral (22 right, 19 left) and 7 bilateral procedures, with an average age of 67.8 (range, 35-88) years at the time of surgery. A questionnaire that included questions regarding postsurgical dorsal midfoot pain relief, surgical result satisfaction, and current functional limitations was administered via telephone. Demographic information, patient responses, and complications were recorded. Results: Of the 48 patients, 80.8% were satisfied with the result of the surgery in relieving their dorsal midfoot pain, 84.6% would repeat the surgery under the same circumstances, 83.8% would recommend the surgery to a friend, 10.4% reported they wish they had undergone arthrodesis, 91.7% reported pain relief in the first 6 months, and 55.6% reported current activity limitations. Six feet (10.9%) underwent a second procedure with an average postoperative time of 20.5 (range, 1-36) months. Complications included 1 hematoma and deep wound infection, 1 DPN neuroma and superficial peroneal nerve entrapment, and 4 patients with inadequate pain relief. Conclusion: In this cohort, DPN neurectomy appeared to be a reasonable surgical alternative to arthrodesis for the management of chronic dorsal midfoot pain due to midfoot osteoarthritis after failed nonoperative management. Level of Evidence: Level IV, retrospective case series.
Isolation and characterization of feline dental pulp stem cells
Authors: Algorta Agustina , Artigas Rody , Rial Analía , Brandl Scott , Rodellar Clementina , Benavides Uruguaysito , Maisonnave Jacqueline , Yaneselli Kevin 
Published: February 2023

Objectives The aim of this study was to isolate feline dental pulp stem cells (fDPSCs) and characterize their clonogenic and proliferative abilities, as well as their multipotency, immunophenotype and cytogenetic stability. Methods Dental pulp was isolated by explant culture from two cats <1 year old at post mortem. Their clonogenicity was characterized using a colony-forming unit fibroblast assay, and their proliferative ability was quantified with a doubling time assay in passages 2, 4 and 6 (P2, P4 and P6, respectively). Multipotency was characterized with an in vitro trilineage differentiation assay in P2, and cells were immunophenotyped in P4 by flow cytometry. Chromosomic stability was evaluated by cytogenetic analysis in P2, P4 and P6. Results The fDPSCs displayed spindle and epithelial-like morphologies. Isolated cells showed a marked clonogenic capacity and doubling time was maintained from P2 to P6. Trilineage differentiation was obtained in one sample, while the other showed osteogenic and chondrogenic differentiation. Immunophenotypic analysis showed fDPSCs were CD45−, CD90+ and CD44+. Structural and numerical cytogenetic aberrations were observed in P2–P4. Conclusions and relevance In this study, fDPSCs from two cats were isolated by explant culture and immunophenotyped. Cells displayed clonogenic and proliferative ability, and multipotency in vitro, and signs of chromosomic instability were observed. Although a larger study is needed to confirm these results, this is the first report of fDPSC isolation and in vitro characterization.