bluuebunny/crossref_metadata_2025_split huggingface dataset:
Outcome of Different Treatment Modalities in Non-caseating Granulomatous Mastitis: A Narrative Review
Authors: Nasrin Shamima , Alam Ovi Mir Rasekh , Arif Abdus Salam , Hasan Md Jahid 
Published: March 2023

Granulomatous mastitis (GM) is a benign inflammatory condition of breast disease that affects women of childbearing age with a history of breastfeeding. The rarity and complex pathophysiology make the diagnosis and management quite dilemmatic for clinicians. This review explored the available treatment options for the disease condition in light of the recent literature. Surgery alone, intervention with or without steroids, antibiotic therapy, abscess drainage, methotrexate therapy, and antibiotics are widely used in different settings. However, surgery (with or without steroids) showed a higher recovery rate along with a lower recurrence rate. Steroid therapy is promising, but its use is limited due to the higher number of recurrences. In addition, the use of methotrexate showed an increased remission rate, but the toxicity profile was still high. However, treatment outcome mostly depends on the severity of the disease and individual physical status, and therefore, a comprehensive evaluation of the patients is crucial. This review recommended the formulation of a standard guideline for uniform management of granulomatous mastitis conditions in our country.
AKMMC J 2022; 13(1) : 47-51
Farmers Perceptions on the Use of Insecticides For Management of Brinjal Shoot and Fruit Borer
Authors: Mannan MA , Islam KS , Jahan M 
Published: March 2023

The survey was conducted in Chattogram, Jashore and Mymensingh regions of Bangladesh to find out the farmers’ knowledge and perceptions about insecticide usages in brinjal for management of brinjal shoot and fruit borer (BSFB) during August 2014 to April 2015. All the farmers of three different study areas reported that BSFB is a major problem and needs to be controlled. On an average, 91.68% farmers used conventional chemical method as main protection technique by using only insecticide whereas only 5.54% farmers used IPM method and 2.78% used different types of cultural pest management techniques for controlling BSFB. On an average, 40.80% farmers used insecticide as single form and 59.20% farmers used it in the form of cocktail. During three and half months crop season 36.35 to 57.33 times spray can occur depending on the regions. On an average, 73.23% farmers followed the advice of pesticide dealers in selecting pesticides and their doses for spraying against BSFB. Only 7.69% farmers followed the advice of extension workers which is much less as compared to the pesticide dealers. On an average, 73.98% farmers reported that insecticide was applied without any protection measures.
Bangladesh J. Agril. Res. 46(4): 457-468, December 2021
UJI EFEK ANALGESIK EKSTRAK DAUN SIRIH HIJAU BANYUWANGI (Piper betle L.) PADA MENCIT PUTIH JANTAN (Mus musculus)
Authors: Lestari Ima Fitria , Syafirah Junieta Fara , Deviani Dita Amanda 
Published: March 2023

The content of flavonoid compounds in betel leaf is used as a protection as analgesic. The purpose of this study was to test the analgesic effects of Banyuwangi green betel leaf extract (Piper betle L.) on male white mice (Mus musculus). The doses of green betel leaf ethanol extract that were used were 4.696 mg, 9.392 mg and 18.784 mg and the positive control were mefenamic acid. The test animals used in this study were white male mice (Mus musculus) that were adapted for about 3 days in experimental environmental conditions. Based on the results of the study, the analgesic effect test of green betel leaf extract (Piper betle L.) can provide analgesic effectiveness on mice (Mus musculus). Ethanol extracts of green betel leaf (Piper betle L.) at doses of 4.696 mg/kgBW were able to provide a good analgesic effect with good responses to white male mice (Mus musculus). The percentage of analgesic power that was close to the percentage of analgesic power of the gold standard which is 69.23%.
Biogenic silver nanoparticles (AgNPs) from Tinosporacordifolia leaves: An effective antibiofilm agent against Staphylococcus aureus ATCC 23235
Authors: Ghosh Sreejita , Mondol Somdutta , Lahiri Dibyajit , Nag Moupriya , Sarkar Tanmay , Pati Siddhartha , Pandit Soumya , Alarfaj Abdullah A. , Mohd Amin Mohamad Faiz , Edinur Hisham Atan , Ahmad Mohd Zain Muhammad Rajaei , Ray Rina Rani 
Published: March 2023

Medicinal plants are long known for their therapeutic applications. Tinospora cordifolia (commonly called gulancha or heart-leaved moonseed plant), a herbaceous creeper widely has been found to have antimicrobial, anti-inflammatory, anti-diabetic, and anti-cancer properties. However, there remains a dearth of reports regarding its antibiofilm activities. In the present study, the anti-biofilm activities of phytoextractof T. cordifolia and the silver nanoparticles made from this phytoextract were tested against the biofilm of S.taphylococcus aureus, one of the major nosocomial infection-producing bacteria taking tetracycline antibiotic as control. Both phytoextract from the leaves of T. cordifolia, and the biogenic AgNPs from the leaf extract of T. cordifolia, were found successful in reducing the biofilm of Staphylococcus aureus. The biogenic AgNPs formed were characterized by UV- Vis spectroscopy, Field emission Scanning Electron Microscopy (FE- SEM), and Dynamic light scattering (DLS) technique. FE- SEM images showed that the AgNPs were of size ranging between 30 and 50 nm and were stable in nature, as depicted by the zeta potential analyzer. MIC values for phytoextract and AgNPs were found to be 180 mg/mL and 150 μg/mL against S. aureusrespectively. The antibiofilm properties of the AgNPs and phytoextract were analyzed using the CV assay and MTT assay for determining the reduction of biofilms. Reduction in viability count and revival of the S. aureus ATCC 23235 biofilm cells were analyzed followed by the enfeeblement of the EPS matrix to quantify the reduction in the contents of carbohydrates, proteins and eDNA. The SEM analyses clearly indicated that although the phytoextracts could destroy the biofilm network of S. aureuscells yet the biogenicallysynthesizedAgNPs were more effective in biofilm disruption. Fourier Transformed Infrared Radiations (FT- IR) analyses revealed that the AgNPs could bring about more exopolysaccharide (EPS) destruction in comparison to the phytoextract. The antibiofilm activities of AgNPs made from the phytoextract were found to be much more effective than the non-conjugated phytoextract, indicating the future prospect of using such particles for combatting biofilm-mediated infections caused by S aureus.
Output power regulation system for portable micro fuel cell systems
Authors: Zhong Shaoxuan , Yuan Weijian , Liu Xiaoqiang , Cao Jiamu , Zhang Yufeng 
Published: March 2023

This article presents an output power regulation system for micro fuel cells to help enhance the stability of the fuel cell in a portable micro power system. The structure of an MCU-controlled DC-DC converter is proposed. Then, the output characteristics of a selected fuel cell stack and the DC-DC converter’s power control functions are estimated by a system-level model. Based on the simulation results, the model provides a power regulation system which is implemented, and the test shows that it fulfills its intended function and the output power is regulated to a fixed level of 5 W–40 W with good efficiency.
Impact of carbon trading policy on corporate capital structure: Empirical evidence from China
Authors: Zhang Zhaolong , Liao Jing , Li Hanlin , Pan Jiaqi 
Published: March 2023

Introduction: The Chinese government has taken the lead in proposing a carbon trading market policy to address the negative impact of excessive carbon emissions on global climate change. Since this policy’s implementation in 2011, it has had a profound impact on economic development and the structure of the national economy. In this context, we aim to study how environmental regulation and transition risks associated with climate change affect corporate capital structure.Methods: Based on data provided by listed companies in China’s energy-intensive sector, this study uses a Difference-in-Difference (DID) model to examine the effect of the carbon trading policy on corporate capital structure.Results: According to our results, we predict that the carbon trading policy will significantly reduce the corporate debt ratio, which remains true even when an instrumental variables approach is used to account for endogeneity and after robustness tests are conducted. This study also shows that the negative effect of the carbon trading policy on corporate capital structure is mainly a product of internal capital demand and external capital supply. In addition, the reduction effect that the carbon trading policy has on the corporate debt ratio is more significant among firms with lower government subsidies and among nonstate-owned firms.Discussion: These findings imply that under the implementation of a carbon trading market policy, firms’ financial decision-making will change significantly in response to the policy-induced shocks of elevated corporate risk behaviour.
Spatial distribution of the demersal chondrichthyan community from the western Mediterranean trawl bycatch
Authors: Ruiz-García David , Raga Juan A. , March David , Colmenero Ana I. , Quattrocchi Federico , Company Joan B. , Recasens Laura , Barría Claudio 
Published: March 2023

IntroductionChondrichthyans (sharks, batoids and chimaeras) play key roles in the regulation of marine food webs dynamics. However, more than half of the assessed species in the Mediterranean are threatened, primarily by fishing pressure and compounded by habitat degradation and climate change. Nevertheless, there is an important knowledge gap in identifying the underlying drivers of their community structure and spatial distribution.Methods and ResultsWe provide insights into the current bycatch rates of chondrichthyans in the western Mediterranean commercial bottom trawling fishery by accurately depicting the unaltered practices of the local fleet. A total of 17 species were recorded in the studied fishing grounds (ranging from 50 to 800 m deep), including 7 sharks, 9 batoids, and 1 chimaera, although the total catch was dominated by few species. Furthermore, we tested the effect of environmental and fishing-related factors on multiple community descriptors by using analysis of community structure (multidimensional scaling and analysis of similitude) and generalized linear mixed models to further understand the drivers of the chondrichthyan community distribution and structure. This study revealed the importance of combining environmental and anthropogenic drivers to further understand the spatial distribution patterns of chondrichthyan communities. Our results indicate that depth was the main driver of the community structure, with deeper areas within the fishing grounds hosting a higher diversity. Sea bottom temperature and substrate type also influenced the distribution of the community, with substrate effects changing depending on the intensity of fishing pressure. In all cases, density, biomass, and diversity of chondrichthyans were negatively impacted by increasing fishing effort. DiscussionUnderstanding the drivers of the structure and distribution of the chondrichthyan community is crucial to understand the potential impacts that increased fishing pressure, habitat loss and global change may entail. The ongoing challenges that the Mediterranean chondrichthyans and their ecosystems are facing highlights the need for continued monitoring and improved chondrichthyan-focused fisheries management.
Different concentrations of Ti4+ as a donor and electronic properties of Bi2-xTixO3
Authors: Alshoaibi Adil , Hussain Fayaz , Mohsin Fatima , Alnaim Nisrin , Almulhem Najla 
Published: March 2023

Bi(2-x)TixO3 (x = 0, 0.01, 0.03. &amp; 0.05) (BO-xT) ceramics are prepared by conventional solid-state route followed by low sintering temperatures. X-ray diffraction analyses show the presence of the monoclinic phase of Bi2O3. The electrical conductivities at room temperature concerning the frequency (ranging from 25 kHz to 5 MHz) and Seebeck Coefficient ranging from 50°C to 400°C were measured. With an increase in Ti (dopant) content, the conductivity and Seebeck Coefficient increased with the temperature increment. The BO-0.03T has the highest Seebeck value (47 μV/°C), which shows a higher carrier concentration. In terms of electrical conductivities, the BO-0.05T ceramic shows the maximum electrical conductivity, i.e. 2.0 × 10−9 μS/m as compared to other samples, which exhibit the presence of free electrons. Moreover, relative permittivity (dielectric constant) and dielectric loss are also measured concerning the frequency at room temperature to investigate the dielectric behaviour of the ceramics. This low-temperature sintering ceramics will open new applications in the domain of electronic materials.
Why do cracks occur in the weld joint of Ti-22Al-25Nb alloy during post-weld heat treatment?
Authors: Shao Ling , Zhang Xinyu , Chen Yingwei , Zhu Liu , Wu Sujun , Liu Qijie , Li Weiwei , Xue Na , Tu Zhibiao , Wang Tianle , Zhang Jitang , Dai Sheng , Shi Xinxing , Chen Mengliang 
Published: March 2023

Ultrasonic pulse frequency tungsten inert gas welding technology was adopted to join Ti-22Al-25Nb alloy. There were some cracks in the Ti-22Al-25Nb alloy weld joint after post-weld heat treatment. The hardness and Young’s modulus of α2, O, and β/B2 phases in Ti-22Al-25Nb alloy were examined with an in situ nanoindentation technique. The phase transition stresses of three different phases in the weld joint of Ti-22Al-25Nb alloy were analyzed to explain why cracks occur in the weld joint of Ti-22Al-25Nb alloy during post-weld heat treatment. The results show that mean hardness is highest for the α2 phase, second-highest for the O phase, and lowest for the β/B2 phase; the mean Young’s modulus has the same trend in Ti-22Al-25Nb alloy. Phase transition stress results in cracks in the weld joint of Ti-22Al-25Nb alloy during post-weld heat treatment. By improving post-weld heat treatment, the ultimate strength of the Ti-22Al-25Nb alloy weld joints reaches 750 MPa, which is 72.5% that of the base material.
Electroacupuncture activated local sympathetic noradrenergic signaling to relieve synovitis and referred pain behaviors in knee osteoarthritis rats
Authors: Chen Wei , Zhang Xiao-Ning , Su Yang-Shuai , Wang Xiao-Yu , Li Heng-Cong , Liu Yi-Han , Wan Hong-Ye , Qu Zheng-Yang , Jing Xiang-Hong , He Wei 
Published: March 2023

IntroductionRecent research has focused on the local control of articular inflammation through neuronal stimulation to avoid the systemic side effects of conventional pharmacological therapies. Electroacupuncture (EA) has been proven to be useful for inflammation suppressing and pain reduction in knee osteoarthritis (KOA) patients, yet its mechanism remains unclear.MethodsIn the present study, the KOA model was established using the intra-articular injection of sodium monoiodoacetate (MIA) (1 mg/50 μL) into the knee cavity. EA was delivered at the ipsilateral ST36-GB34 acupoints. Hind paw weight-bearing and withdrawl thresholds were measured. On day 9, the histology, dep enrichment proteins, cytokines contents, immune cell population of the synovial membrane of the affected limbs were measured using HE staining, Masson staining, DIA quantitative proteomic analysis, flow cytometry, immunofluorescence staining, ELISA, and Western Blot. The ultrastructure of the saphenous nerve of the affected limb was observed using transmission electron microscopy on the 14th day after modeling.ResultsThe result demonstrated that EA intervention during the midterm phase of the articular inflammation alleviated inflammatory pain behaviors and cartilage damage, but not during the early phase. Mid-term EA suppressed the levels of proinflammatory cytokines TNF-α, IL-1β, and IL-6 in the synovium on day 9 after MIA by elevating the level of sympathetic neurotransmitters Norepinephrine (NE) in the synovium but not systemic NE or systemic adrenaline. Selective blocking of the sympathetic function (6-OHDA) and β2-adrenergic receptor (ICI 118,551) prevented the anti-inflammatory effects of EA. EA-induced increment of the NE in the synovium inhibited the CXCL1-CXCR2 dependent overexpression of IL-6 in the synovial macrophages in a β2-adrenergic receptor (AR)-mediated manner.DiscussionThese results revealed that EA activated sympathetic noradrenergic signaling to control local inflammation in KOA rats and contributed to the development of novel therapeutic neurostimulation strategies for inflammatory diseases.
A bibliometric analysis based on Web of Science from 2012 to 2021: Current situation, hot spots, and global trends of medullary thyroid carcinoma
Authors: Li Ruyin , Wang Yingjiao , Zhao Zirui , Li Xiaobin , Liu Ziwen 
Published: March 2023

BackgroundMedullary thyroid carcinoma (MTC) is a special type of thyroid carcinoma derived from the C cell of the thyroid gland. Because of the poor prognosis of MTC, a large number of studies on MTC have been conducted in the last 10 years. To better comprehend, it is necessary to clarify and define the dominant countries, organizations, core journals, important authors, and their cumulative research contributions, as well as the cooperative relationships between them.MethodEnglish publications with article type article or review about MTC from January 2012 to December 2021 was retrieved from Web of Science core collection, and VOSviewer, CiteSpace, and Microsoft Excel were applied for bibliometric study.ResultA total of 1208 articles and reviews were included in this study. The 1208 papers were written by 6364 authors from 1734 organizations in 67 countries, published in 408 journals, and cited 24118 references from 3562 journals. The number of publications was essentially flat from 2012-2021, with the largest proportion of publications coming from the U.S., followed by Italy and China. Thyroid was the most productive journal, and Journal of clinical endocrinology &amp; metabolism was the most cited journal. University of Texas MD Anderson Cancer Center was the most productive institution and Luca Giovanella, was the most productive author. Diagnostic tools, surgical treatment, non-surgical treatment, genetics and relationship with other endocrine diseases were the main research interests in this field. Prognosis has been a cutting-edge topic since 2017.ConclusionAs a thyroid cancer with poor prognosis, MTC has received continuous attention in recent years. Current MTC studies mainly focused on disease intervention, mechanism research and prognosis. The main point of this study is to provide an overview of the development process and hot spots of MTC in the last decade. These might provide ideas for further research in the MTC field.
Impressive reduction of brain metastasis radionecrosis after cabozantinib therapy in metastatic renal carcinoma: A case report and review of the literature
Authors: Lolli Jacopo , Tessari Francesca , Berti Franco , Fusella Marco , Fiorentin Davide , Bimbatti Davide , Basso Umberto , Busato Fabio 
Published: March 2023

IntroductionRadionecrosis is a consequence of SRS (stereotactic radiosurgery) for brain metastases in 34% of cases, and if symptomatic (8%–16%), it requires therapy with corticosteroids and bevacizumab and, less frequently, surgery. Oncological indications are increasing and appropriate stereotactic adapted LINACs (linear accelerators) are becoming more widely available worldwide. Efforts are being made to treat brain radionecrosis in order to relieve symptoms and spare the use of active therapies.Case presentationHerein, we describe a 65-year-old female patient presenting with brain radionecrosis 6 months after stereotactic radiotherapy for two brain metastatic lesions. Being symptomatic with headache and slow cognitive-motor function, the patient received corticosteroids. Because of later lung progression, the patient took cabozantinib. An impressive reduction of the two brain radionecrosis areas was seen at the brain MRI 2 months after the initiation of the angiogenic drug.DiscussionThe high incidence of radionecrosis (2/2 treated lesions) can be interpreted by the combination of SRS and previous ipilimumab that is associated with increased risk of radionecrosis. The molecular mechanisms of brain radionecrosis, and its exact duration in time, are poorly understood. We hypothesize that the antiangiogenic effect of cabozantinib may have had a strong effect in reducing brain radionecrosis areas.ConclusionIn this clinical case, cabozantinib is associated with a fast and significant volume reduction of brain radionecrosis appearing after SRS and concomitant immunotherapy. This drug seems to show, like bevacizumab, clinical implications not only for its efficacy in systemic disease control but also in reducing brain radionecrosis. More research is needed to evaluate all molecular mechanisms of brain radionecrosis and their interaction with systemic therapies like third-generation TKIs.
Physiologically based pharmacokinetic-pharmacodynamic evaluation of meropenem in CKD and hemodialysis individuals
Authors: Deng Guoliang , Yang Fan , Sun Ning , Liang Danhong , Cen Anfen , Zhang Chen , Ni Suiqin 
Published: March 2023

Objective: Chronic kidney disease (CKD) has significant effects on renal clearance of drugs. The application of antibiotics in CKD patients to achieve the desired therapeutic effect is challenging. This study aims to determine meropenem plasma exposure in the CKD population and further investigate optimal dosing regimens.Methods: A healthy adult PBPK model was established using the meropenem’s physicochemical parameters, pharmacokinetic parameters, and available clinical data, and it was scaled to the populations with CKD and dialysis. The differences between the predicted concentration, Cmax, and AUClast predicted and observed model values were assessed by mean relative deviations (MRD) and geometric mean fold errors (GMFE) values and plotting the goodness of fit plot to evaluate the model’s performance. Finally, dose recommendations for CKD and hemodialysis populations were performed by Monte Carlo simulations.Results: The PBPK models of meropenem in healthy, CKD, and hemodialysis populations were successfully established. The MRD values of the predicted concentration and the GMFE values of Cmax and AUClast were within 0.5–2.0-fold of the observed data. The simulation results of the PBPK model showed the increase in meropenem exposure with declining kidney function in CKD populations. The dosing regimen of meropenem needs to be further adjusted according to the renal function of CKD patients. In patients receiving hemodialysis, since meropenem declined more rapidly during the on-dialysis session than the off-dialysis session, pharmacodynamic evaluations were performed for two periods separately, and respective optimal dosing regimens were determined.Conclusion: The established PBPK model successfully predicted meropenem pharmacokinetics in patients with CKD and hemodialysis and could further be used to optimize dosing recommendations, providing a reference for personalized clinical medication.