bluuebunny/crossref_metadata_2025_split huggingface dataset:
The comparison of the coping styles between patients in ultra- high risk for psychosis state, first episode of psychosis and chronic schizophrenia.
Authors: Rek-Owodziń Katarzyna Izabela , Tyburski Ernest , Plichta Piotr , Waszczuk Katarzyna , Bielecki Maksymilian , Wietrzyński Krzysztof , Podwalski Piotr , Rudkowski Krzysztof , Michalczyk Anna , Mak Monika 
Published: May 2023

Aim of the studyThe aim of this study was to investigate differences in coping styles between individuals at ultra high risk for psychosis, with first episode psychosis, chronic schizophrenia and healthy controls.Subject or material and methodsA total of 167 individuals with chronic schizophrenia (CHS; n=66), first episode psychosis (FEP; n=31), at ultra high risk for psychosis (UHR; n=16) and healthy controls (HC; n=54) were recruited to complete the Coping Inventory for Stressful Situations (CISS) to investigate their preferred coping styles. Demographic data were collected using a short self-designed questionnaire.ResultsOur results demonstrated all participants’ preference for mixed coping (i.e. a strategy in which two or three styles are applied with similar frequency). The second choice across the control group was task-oriented, and in the clinical groups - emotion-oriented coping. Interestingly, task-oriented coping was significantly more frequent in controls relative to the clinical groups, while the frequency of emotion-oriented coping did not differ significantly across our sample. Avoidance-oriented coping was reported significantly more frequently in the CHS compared to both HC and UHR.DiscussionThis study demonstrates differences in coping with stressful situations between patients at various stages of psychosis and healthy individuals.ConclusionsTherapeutic interventions for patients from the psychosis spectrum should include education on coping with stress and practical training of coping skills.
Infertility in patients with Inflammatory Bowel Disease (IBD): a challenge to overcome
Authors: Aab Arkadiusz , Zarańska Julia , Miejska-Kamińska Marta , Kamiński Filip , Liszka Adriana 
Published: May 2023

Introduction: Inflammatory bowel disease (IBD) is a group of chronic digestive disorders that affects an increasing number of people. As the peak incidence of IBD occurs during the reproductive age and affects young people, it is worth examining the impact of IBD on the fertility of patients. In view of the growing problem of infertility in society and the probable relationship between decreased reproductive function and the occurrence of chronic diseases, it is reasonable to examine this phenomenon in detail.
Objective: The aim of this study is to summarize the current knowledge on the association between IBD and infertility based on available literature.
Materials and methods: A literature review was conducted using PubMed and Google Scholar databases with the following search terms: IBD, infertility, infertility diagnosis, the relationship between IBD and infertility, drugs and infertility, psychological aspects of infertility in IBD.
State of knowledge: There are few meta-analyses on the association between IBD and infertility in the literature, and this is due to the small number of studies on this topic.
Conclusions: Infertility is becoming an increasingly common problem in people with IBD. Stress and anxiety disorders can have a negative impact on the course of the disease, and thus limit reproductive opportunities. Taking medications to control the course of the disease is crucial for patients to remain in remission, however, patients should be informed about the impact of some medications on reproduction and adjust their conception plans according to their current therapy. Treatment of the underlying disease, reducing anxiety levels, regular physical activity, and a healthy and balanced diet are all components of appropriate management in people with IBD who are trying to conceive. Without these pillars, it is difficult to guarantee successful pregnancy outcomes.
Editorial
Authors: Conde Heliana 
Published: May 2023

O ensaio que abre este número de Mnemosine evoca o contundente poema de Brecht, Intertexto, que situou, no passado, a chegada dos invasores - os que ocupam nossas casas aos poucos, sem serem notados, até que nos expulsam. Primeiro levaram os negros/ Mas não me importei com isso/ Eu não era negro Em seguida levaram alguns operários/ Mas não me importei com isso/ Eu também não era operário Depois prenderam os miseráveis/ Mas não me importei com isso/ Porque eu não sou miserável Depois agarraram uns desempregados/ Mas como tenho meu emprego/ Também não me importei Agora estão me levando/ Mas já é tarde. Como eu não me importei com ninguém/ Ninguém se importa comigo. Cada vez é mais necessário criar vacúolos de silêncio em meio a um insuportável vozerio. Assim, creio que basta o poema de Brecht ao Editorial de Mnemosine nesse primeiro número de 2023. Obrigada a todxs que colaboraram.Saúde, alegria.Também querem levá-las.Mas, no caso, isso nos importa e não estamos dispostxs a permitir..... Heliana de Barros Conde Rodrigues
Da incidência marxista na formação profissional e produção acadêmica em serviço social: notas introdutórias
Authors: Pontes Reinaldo Nobre 
Published: May 2023

Este ensaio apresenta reflexões analíticas sobre a influência do pensamento marxista no Serviço Social brasileiro, na particularidade da formação e produção científica desde os anos 1990. Adotou-se a pesquisa bibliográfica, tomando-se como referência livros de Serviço Social e artigos em periódicos (A1) mais influentes que abordaram a interface das categorias “marxismo”, “formação profissional”, “produção acadêmica”, “Serviço Social”. Tomou-se a concepção crítico-dialética do processo histórico da profissão e seus determinantes como referência. Em face aos dados obtidos e às experiências pessoalmente testemunhadas e protagonizadas, conclui-se sobre a decisiva influência nas formas de concepção, organização e direção teórico-metodológica, ético-política e prática da formação de assistentes sociais, especialmente a partir da década de 1990, como também no redirecionamento crítico da produção científica, notadamente nos programas de pós-graduação. Identificam-se também claras ameaças a este patrimônio crítico, seja com o aligeiramento privatista/não presencial crescente na formação profissional, seja pela ascensão do conservadorismo e do pós-modernismo. Palavras-Chave: marxismo; Serviço Social; formação profissional; produção acadêmica.
La mixtura metodológica como superación de viejas prácticas en la investigación social
Authors: Verd Joan Miquel , Lozares Carlos 
Published: May 2023

En el artículo se presentan dos vías metodológicas de superación de la dicotomía entre el enfoque cuantitativo y el enfoque cualitativo. Por un lado, se presenta y explica en qué consiste la lógica abductiva de investigación, que incorpora características del razonamiento deductivo y del inductivo, sin ser su suma, lo cual le confiere unas características específicas. Por otro lado, se propone desarrollar con todas sus consecuencias el enfoque de los métodos mixtos, que en su aplicación más habitual y ortodoxa se ha quedado a medio camino en relación con su promesa de superación de la escisión entre los métodos cuantitativos y cualitativos. Este desarrollo encaja con denominaciones como “investigación mixta” o “investigación mediante la fusión de métodos”. Tanto una vía como otra ofrecen sendas que permiten superar viejas prácticas ancladas en la oposición cuantitativa-cualitativa, a la que a menudo se otorga un carácter paradigmático. Palabras clave: diseño de investigación; abducción; métodos mixtos; paradigmas de investigación; investigación mixta. Resumo – O artigo apresenta dois caminhos metodológicos para superar a dicotomia entre a abordagem quantitativa e a abordagem qualitativa. Por um lado, apresenta-se e explica-se em que consiste a lógica da investigação abdutiva, que incorpora características do raciocínio dedutivo e indutivo, sem ser a sua soma, o que lhe confere características específicas. Por outro lado, propõe-se desenvolver a abordagem de métodos mistos com todas as suas consequências, que em sua aplicação mais comum e ortodoxa ficou a meio caminho em relação à sua promessa de superar a divisão entre métodos quantitativos e qualitativos. Esse desenvolvimento se enquadra em denominações como “pesquisa mista” ou “pesquisa pela fusão de métodos”. Tanto uma quanto a outra oferecem caminhos que permitem a superação de velhas práticas ancoradas na oposição quantitativo-qualitativa, muitas vezes dotada de caráter paradigmático. Palavras-Chave: projeto de pesquisa; abdução; métodos mistos; paradigmas de pesquisa; pesquisa mista.
The Visual Art to Improve Skills for Paediatrics Staff
Authors: Ferrara Vincenza , Franceschini Alessandro , Morlacchetti Riccardo , Giannini Luigi , Iacobini Metello 
Published: May 2023

In healthcare working contexts, individuals are required to have a set of transversal skills that can be distinguished in technical-specialist, communicative-relational and organizational-management skills. This is the reason why interprofessional training has become a requirement in hospital wards. Art has been shown to be effective tools in educating medical students and healthcare professionals to a better self-awareness, reflective practice with the aim of better communication with the patient, better stress management, less burn-out etc. The aim of this study is to evaluate the use of art as a tool for the development of useful skills as observation, problem solving, critical thinking, communication, tolerance of ambiguity in paediatric practice.
Method: The staff of the Umberto I paediatric department’s staff was chosen to be enrolled: 2 paediatricians, 3 nurses and 2 residents. A control group of 4 nurses and 1 resident was included in the study. The involved personnel participated in 4 to 8 one-hour meetings in two months. During these meetings, works of art were proposed by applying the method of Visual Thinking Strategies and other useful art practices to reinforce active listening and empathy. Validated test, VTSKill grid, was administered to evaluate the improvement of skills.
Results: The comparison between pre and post-tests gave positive results in terms of Critical Thinking, Observation, Linguistic expression, problem solving and therefore analysis and communication skills. Same results were not recorded in the personnel who did not participate in the activities, registering in some cases a regression from the initial test.
Conclusion: This experience, although realized with few participants, confirmed other experiences that have been suggesting Medical Humanities and in particular the Visual Art as a tool to improve useful skills and relationships within the staff of hospital departments. According to our experience, we believe improvement of some skills can be useful in the paediatric practice where the use of attentive listening, observation skills, communication through visual aids can improve the relationship with young patients and their families.
D-index and invasive fungal infections (IFIs) in adult acute myeloid leukemia (AML) patients with the first episode of febrile neutropenia
Authors: Rattanathammethee Thanawat , Munsamai Kawin , Punnachet Teerachat , Hantrakun Nonthakorn , Piriyakhuntorn Pokpong , Hantrakool Sasinee , Chai-Adisaksopha Chatree , Rattarittamrong Ekarat , Tantiworawit Adisak , Norasetthada Lalita 
Published: May 2023

Introduction
This study aimed to evaluate the performance of the D-index, a calculated measure of neutropenic burden, in predicting the risk of invasive fungal infections (IFIs) in acute myeloid leukemia (AML) patients.

Methods
A retrospective study of adult AML patients who received the first induction chemotherapy and developed febrile neutropenia was conducted. Clinical characteristics, laboratory data, and the calculation of the D-index and cumulative D-index (c-D-index) were collected and analyzed between patients with and without IFIs.

Results
A total of 101 patients were included, with 16 (15.8%) patients who developed IFIs. Clinical characteristics, antifungal prophylaxis, and AML cytogenetic risk were similar between patients with or without IFIs. The results showed that the D-index and c-D-index were more effective in predicting IFIs than the duration of neutropenia. With the D-index cutoff of 7083, the sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were 81.3%, 83.5%, 48.2%, and 95.9%, respectively. c-D-index at 5625 revealed sensitivity, specificity, PPV, and NPV for IFIs of 68.8%, 68.2%, 28.9%, and 92.1%, respectively. Using this cutoff of c-D-index, patients without IFIs were overtreated with an antifungal regimen in 45 (52.9%) cases.

Conclusion
The D-index and c-D-index were helpful indicators for defining the risk of IFIs in AML patients with febrile neutropenia.
A propósito de un caso: Tumor de Pott en Pediatría
Authors: Esmeral Atehortúa Koretta , Thomen Ojeda Olga Lucia , Covilla Varela Melany Daniela , Nader Salgado Fhara , Muñoz Orozco Leidi Cristina , Zuñiga Latorre Camilo Andres , Cespedes Eslait Ayda Maria 
Published: May 2023

Antecedentes: el tumor de Pott es una entidad poco frecuente en pediatría, hace parte de las complicaciones de la sinusitis frontal y se caracteriza por el desarrollo de una masa en la región frontal con edema perilesional y absceso subperióstico producto de osteomielitis del hueso frontal. Reporte de caso: se discute el caso de un paciente de siete años de vida, quien ingresó al servicio de urgencias por fiebre y cefalea. Se realizó un enfoque diagnóstico inicial de síndrome febril secundario a infección de piel y tejidos blandos, con la posterior realización de una tomografía de cráneo simple, que identificó osteomielitis de hueso frontal, pansinusitis y absceso epidural derecho, se enfoca como síndrome febril prolongado secundario a Tumor de Pott y se remite a neurocirugía para manejo integral. Conclusiones: siendo el Tumor de Pott una entidad poco frecuente en pediatría es de suma importancia diagnosticarlo de manera oportuna, ya que implica una complicacion que podría poner en riesgo la vida del paciente. El tratamiento integral dependerá del tamaño, la localización y de la implicación clínica, variando desde manejo farmacológico hasta cirugías correctivas.
Diagnóstico prenatal de Trombocitopenia-Aplasia Radial (TAR): Reporte de un caso y revisión de la literatura
Authors: Aivasovsky Trotta Ivan Constantino , Rincones Rojas Lorena Victoria , Vergara Cardenas Sergio Andres , Parra Charris Andrés , Zannin Ferrero Andreina , Ferrer Marcano Amenaida Carolina , Bracho Fernandez Ana Isabel , Fernandez Gonzalez Isabel , Celis Regalado Luis Gustavo 
Published: May 2023

Antecedentes: el síndrome de trombocitopenia con aplasia de radio (TAR) es un desorden congénito con un patrón de herencia autosómico recesivo de prevalencia desconocida y que afecta a menos de 1 caso por cada 100.000 nacidos vivos sin diferencia entre sexos. Se caracteriza por ausencia de radio bilateral, presencia de pulgares y trombocitopenia. Además, puede estar asociado a diversas anomalías cráneo-faciales y en extremidades inferiores, al igual que a patologías cardiacas, urogenitales y gastrointestinales. Reporte de caso: paciente primigestante, a quien se le realiza diagnóstico in utero a la semana 19 de gestación de sospecha de síndrome TAR por hallazgos ecográficos (ausencia bilateral de radios), es referida para evaluación genética y se decide realizar cordocentesis a la semana 25 evidenciando trombocitopenia y anemia. Por alto riesgo de complicaciones fetoplacentarias se realiza manejo in-útero mediante transfusión de hemoderivados y controles prenatales estrictos. El embarazo es llevado a termino y se realiza cesárea en la semana 38 sin complicaciones durante la adaptación neonatal. Conclusiones: el síndrome TAR está asociado a un alto riesgo de mortalidad durante el periodo neonatal y el primer año de vida, por lo cual, un diagnóstico prenatal temprano es de gran importancia para permitir un tratamiento oportuno y mejorar la esperanza y la calidad de vida del recién nacido y sus padres.
IL12/23 Blockade for Refractory Immune-Mediated Colitis: 2-Center Experience
Authors: Shirwaikar Thomas Anusha , Lee Seung Eun , Shatila Malek , De Toni Enrico N. , Török Helga-Paula , Ben Khaled Najib , Powell Nicholas , Weight Ryan , Faleck David M. , Wang Yinghong 
Published: May 2023

INTRODUCTION:
Immune checkpoint inhibitor–mediated colitis (IMC) is commonly managed with steroids and biologics. We evaluated the efficacy of ustekinumab (UST) in treating IMC refractory to steroids plus infliximab and/or vedolizumab.

RESULTS:
Nineteen patients were treated with UST for IMC refractory to steroids plus infliximab (57.9%) and/or vedolizumab (94.7%). Most of them had grade ≥3 diarrhea (84.2%), and colitis with ulceration was present in 42.1%. Thirteen patients (68.4%) attained clinical remission with UST, and mean fecal calprotectin levels dropped significantly after treatment (629 ± 101.5 mcg/mg to 92.0 ± 21.7 mcg/mg, P = 0.0004).

DISCUSSION:
UST is a promising therapy for the treatment of refractory IMC.
CRHR1 polymorphism at rs242941, rs242940, and rs72834580: association of symptoms improvement with intranasal corticosteroids in allergic rhinitis Jordanian patients
Authors: Zihlif Malek , Abusara Osama H. , Al-Qerem Walid , Al-Ibadah Mahmood , Mahafza Tareq M. , Al-Akhras Fatima M. , Mahafza Naseem T. 
Published: May 2023

Abstract

Objectives
Rhinitis is classified into several types with allergic rhinitis (AR) being the most common. AR is among the inflammatory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), in which corticosteroids are administered to overcome the decrease in cortisol production. The treatment options available for AR vary with 1st line treatment being intranasal corticosteroids (INCS). The responsiveness to corticosteroids is due to their binding to corticotropin-releasing hormone receptor-1 (CRHR1). Various studies have studied the responsiveness to corticosteroids treatment in patients with asthma and COPD in association with CRHR1 gene single nucleotide polymorphisms (SNPs).

Methods
In our study, we investigated the association of three SNPs of CRHR1 gene (rs242941, rs242940, and rs72834580) with symptoms improvement post-treatment in AR patients. Blood samples were collected from 103 patients for DNA extraction and gene sequencing. Those patients started to receive INCS for 8 weeks and their symptoms were assessed, through a questionnaire, before treatment and post-treatment to check for symptoms improvement.

Results
Our data showed that improvement of eye redness is significantly less following INCS treatment in patients with allele (C) (AOR=0.289, p-value-0.028, 95 % CI=0.096–0.873) and genotype (CC) (AOR=0.048, p-value-0.037, 95 % CI=0.003–0.832) of rs242941 SNP. There was no correlation with other genotypes, alleles, or haplotypes of the investigated SNPs.

Conclusions
Our findings show that there is no correlation between CRHR1 gene polymorphism and symptoms improvement following INCS treatment. Further studies are required to evaluate the association of INCS and symptoms improvement post-treatment with larger sample size.
A fuzzy-logic-based smart power management strategy for reliability enhancement of energy storage system in a hybrid AC-DC microgrid with EV charging station
Authors: Jagan Amar , Ray Pravat Kumar , Behera Bhanu Pratap , Panda Gayadhar 
Published: May 2023

AbstractAs Electric Vehicles (EVs) are considered as the future of the automobile industry, the demand for EV charging stations immensely rises. Though grid support can be expected for a microgrid (MG), it is highly advantageous to be self-reliant and be prepared for standalone operation for a long duration. This paper proposes a hybrid ac/dc microgrid (HMG) with an EV charging station in standalone mode with a smart power management strategy that increases the reliability of operation. Different modes of operation are designed according to power consumption levels and the operation of MG is switched between these modes considering the solar irradiance and battery bank state of charge. The decision-making system uses a combination of (a) fuzzy logic approach based on the state of charge of the energy storage system (ESS) and solar irradiance, adding to the intelligence of the system and providing smart reasoning capability and (b) logical decisions based on solar power and battery state of charge, considering all possible operating scenarios. With the proposed power management strategy in place, the standalone hybrid microgrid system is found to be able to prolong the discharge of the energy storage system under critical conditions of low battery state of charge and PV power availability and also under highly critical situations will be able to meet the critical load demand making use of the power available in the EV connected. Emphasis has also been given to maintaining the stability of the system while performing shifts in operating modes and during sudden changes in the scenario. Different operating conditions are recognized by the power management module in the model and an appropriate power management strategy is applied. Real-time simulation of the model was done in OPAL-RT real-time simulator using RT-LAB software and simulation results were reproduced.
Chemical composition, antioxidant, and enzyme inhibitory properties of Rauwolfia vomitoria extract
Authors: Adebayo Adeniyi A. , Ademosun Ayokunle O. , Oboh Ganiyu 
Published: May 2023

Abstract

Objectives

Rauwolfia vomitoria is one ethno-botanicals in Nigeria used by traditional health practitioners in managing several human diseases. However, necessary information regarding its effect on enzymes implicated in the development and progression of erectile dysfunction is missing in the literature. Thus, this study investigated the antioxidant property and impact of Rauwolfia vomitoria extract on erectile dysfunction-related enzymes in vitro.

Methods
High performance liquid chromatography was used to identify and quantify Rauwolfia vomitoria’s phenolic components. Then, utilizing common antioxidant assays, the extract’s antioxidant properties were evaluated and finally the effect of the extract on some enzymes (AChE, arginase and ACE) implicated in erectile dysfunction was investigated in vitro.

Results
The results showed that the extract inhibited AChE (IC50=388.72 μg/mL), arginase (IC50=40.06 μg/mL) and ACE (IC50=108.64 μg/mL) activities. In addition, phenolic rich extract of Rauvolfia vomitoria scavenged radicals and chelated Fe2+ in concentration dependent manner. Furthermore, rutin, chlorogenic acid, gallic acid, and kaempferol were found in large quantities by HPLC analysis.

Conclusions
Therefore, one of the potential reasons driving Rauwolfia vomitoria’s use in folk medicine for the treatment of erectile dysfunction could be its antioxidant and inhibitory activities on several enzymes linked to erectile dysfunction in vitro.