bluuebunny/crossref_metadata_2025_split huggingface dataset:
Murine leukemia virus can infect non-dividing cells
Authors: Salas-Briceno Karen , Zhao Wenming , Ross Susan R. 
Published: August 2023

AbstractRetroviral reverse transcription starts within the capsid and uncoating and reverse transcription are mutually dependent. There is still debate regarding the timing and cellular location of HIV’s uncoating and reverse transcription and whether it occurs solely in the cytoplasm, nucleus or both. HIV can infect non-dividing cells because there is active transport of the preintegration complex (PIC) across the nuclear membrane, but Murine Leukemia Virus (MLV) is thought to depend on cell division for replication and whether MLV uncoating and reverse transcription is solely cytoplasmic has not been studied. Here, we used NIH3T3 and primary mouse dendritic cells to determine where the different stages of reverse transcription occur and whether cell division is needed for nuclear entry. Our data strongly suggest that in both NIH3T3 cells and dendritic cells (DCs), the initial step of reverse transcription occurs in the cytoplasm. However, we detected MLV RNA/DNA hybrid intermediates in the nucleus of dividing NIH3T3 cells and non-dividing DCs, suggesting that reverse transcription can continue after nuclear entry. We also found that the MLV PIC requires cell division to enter the nucleus of NIH3T3 cells. In contrast, we show that MLV can infect non-dividing primary DCs, although integration of MLV DNA in DCs still required the viral p12 protein. Knockdown of several nuclear pore proteins dramatically reduced the appearance of integrated MLV DNA in DCs but not NIH3T3 cells. Additionally, MLV capsid associates with the nuclear pore proteins NUP358 and NUP62 during infection. These findings suggest that simple retroviruses, like HIV, gain nuclear entry by traversing the nuclear pore complex in non-mitotic cells.Author SummaryIt is widely believed that gammaretroviruses like MLV require cell division to achieve nuclear entry and complete their replication. We show here that while this is true for rapidly dividing tissue culture cells, in quiescent cells like dendritic cells, the natural targets of MLV infection, the virus establishes infection without cell division. These studies show that the requirements for retrovirus infection depend on the cell type.
Visual Display Interface (VDI): A MATLAB Software Library For Simulating and Processing In-Vivo Magnetic Resonance Spectroscopy and Spectroscopic Imaging Data
Authors: Liu Yiling , Oeltzschner Georg , Ronen Itamar , Schmidt Rita , Seginer Amir , Kirov Ivan , Wu Dan , Zhang Zhiyong , Tal Assaf 
Published: August 2023

AbstractWe describe a new comprehensive and open-source MATLAB library, called the Visual Display Interface (VDI), designed to process, model, quantify and visualize magnetic resonance spectroscopy (MRS) and spectroscopic imaging (MRSI) data. The library focuses on three major strengths: promoting reproducible research by creating comprehensive data logging and reporting and identifying outlier datasets; seamlessly combining spectral and spatial processing of both single and multivoxel data; and offering a modern, object-oriented design. VDI handles a wide range of common tasks, including spectral and spatial transforms, built-in spectral fitting, absolute quantification, and running density-matrix simulations for coupled and uncoupled spin systems to generate appropriate basis sets and aid in sequence design. VDI interfaces with the Statistical Parameteric Mapping (SPM) toolbox to carry out tissue segmentation, calculate tissue fractions within voxels, derive mean metabolite values from regions of interest defined by anatomical or functional atlases, and perform linear regression for global white matter and gray matter metabolite concentrations. The library’s workings are demonstrated for two tasks: (1) Pre-processing, fitting and analysis of single-voxel proton MRS data from healthy volunteers; and (2) Extracting region-specific metabolite concentrations from spectroscopic imaging data based on an existing cortical atlas in MNI space, and calculating average gray and white matter global concentrations using linear regression.
Association between pre-existing conditions and hospitalization, intensive care services and mortality from COVID-19 – a cross sectional analysis of an international global health data repository
Authors: Elsayed Basant M. S. , Altarawneh Lina , Farooqui Habib Hassan , Khan Muhammed Naseem , Babu Giridhara Rathnaiah , Doi Suhail A.R. , Chivese Tawanda 
Published: August 2023

AbstractObjectiveTo investigate the association between pre-existing conditions and hospitalization, need for intensive care services (ICU) and mortality due to COVID-19.MethodsWe used data on all cases recorded in the Global Health Data repository up to the 10thof March 2021 to carry out a cross-sectional analysis of associations between cardiovascular diseases (CVD), hypertension, diabetes, obesity, lung diseases and kidney disease and hospitalization, ICU admission and mortality due to COVID-19. The Global Health repository reported data from 137 countries, but only Brazil, Mexico and Cuba reported more than 10 COVID-19 cases in participants with preexisting conditions. We used multivariable logistic regression to compute adjusted odds ratios (aOR) of the three outcomes for each pre-existing condition in ten-year age groups from 0-9 years and up to 110-120 years.ResultsThe Global Health repository held 25 900 000 records of confirmed cases of COVID-19, of which 2 900 000 cases were from Brazil, Mexico and Cuba. The overall adjusted odds of hospitalization for the selected pre-existing condition were; CVD (OR 1.7, 95%CI 1.7-1.7), hypertension (OR 1.5, 95%CI 1.4-1.5), diabetes (OR 2.2, 95%CI 2.1-2.2), obesity (OR 1.7, 95%CI 1.6-1.7), kidney disease (OR 5.5, 95%CI 5.2-5.7) and lung disease (OR 1.9, 95%CI 1.8-1.9). The overall adjusted odds of ICU admission for each pre-existing condition were; CVD (OR 2.1, 95%CI 1.8-2.4), hypertension (OR 1.3, 95%CI 1.2-1.4), diabetes (OR 1.7, 95%CI 1.5-1.8), obesity (OR 2.2, 95%%CI 2.1-2.4), kidney disease (OR 1.4, 95%CI 1.2-1.7) and lung disease (OR 1.1, 95%CI 0.9-1.3). The overall adjusted odds of mortality for each pre-existing condition were; CVD (OR 1.7, 95%CI 1.6-1.7), hypertension (OR 1.3, 95%CI 1.3-1.4), diabetes (OR 2.0, 95%CI 1.9-2.0), obesity (OR 1.9, 95%CI 1.8-2.0), kidney disease (OR 2.7, 95%CI 2.6-2.9) and lung disease (OR 1.6, 95%CI 1.5-1.7). The odds of each outcome were considerably larger in children and young adults with these preexisting conditions than for adults, especially for kidney disease, CVD, and diabetes.ConclusionThis analysis of a global health repository confirms associations between pre-existing diseases and clinical outcomes of COVID-19. The odds of these outcomes are especially elevated in children and young adults with these preexisting conditions.
Exploring consumer perceptions and familiarity on apple production and processing under different conditions: conventional, organic, home-made, artisanal and industrial
Authors: Espinosa-Brisset Lucia , Pénicaud Caroline , Souchon Isabelle , Saint-Eve Anne 
Published: August 2023

PurposeThe purpose of this paper is to better understand consumer's familiarity with fruit processing as well as how fruit production conditions (organic and conventional farming), processing conditions (homemade, artisanal and industrial) and the type of processing (e.g. applesauce, apple cider and apple sorbet) influence consumer perceptions of processed fruits.Design/methodology/approachAn online survey questionnaire was applied to 1,000 people living in France. The people represented different genders, ages (18–60+) and sociodemographic categories. Participants were categorized based on their produce purchasing habits (conventional, local, organic, local-organic). The questionnaire contained multiple choice and five point Likert scale questions. Data were analyzed using non-parametric tests.FindingsThe authors found that participants saw year-round availability, fruit preservation and food waste reduction as processing advantages. Locally sourced products were preferred to organic products. The perceived disadvantages to processing were additive usage, nutrient loss and packaging. For consumers, these disadvantages drove highly differentiated perceptions of industrial versus artisanal/homemade apple products. Processing conditions appeared to matter far more than production conditions (organic vs. conventional). In general, consumers weren't familiar with processing operations, awareness was greater for consumers of local and/or organic produce than conventional consumers.Social implicationsThere must be a societal transition toward healthier diets, and food technologies. Informed consumers, might be better equipped to make healthy, informed choices if the consumers are given quality information about food production and processing at different levels.Originality/valueResearch has shown that consumers view fresh organic fruit positively, but only few studies have looked at perceptions of processed fruit products and their familiarity with processing operations. Results of this study demonstrate that consumers could make better choices if the consumers are given quality information about fruit production and processing.
Institution quality and stock price crash risk: a global perspective
Authors: Wang Cong , Lu Yifan 
Published: August 2023

PurposeThis study aims to provide empirical evidence on the relationship between formal institutions and stock price crash risk from a global perspective.Design/methodology/approachThis paper uses data of 35,468 firms globally over the years 1987–2019 and address the endogeneity issue by employing the Mundlak random effects estimator.FindingsThe authors find a significant negative impact of institution quality on stock price crash risk (i.e. better institutions reduce crash risk), after controlling for common determinants of crash risk such as leverage, return on asset, firm size, investment, etc. as well as macro factors such as GDP growth. This effect is robust to different measures of crash risk and sub-indicators of institutions quality. In addition, the authors also find this effect to be universally present in economies characterized by different levels of income.Originality/valueTo the best of the authors' knowledge, there's no known study that explores the potential causal relationship between institution quality and stock price crash risk. Therefore, the research topic in this study is original and can contribute significantly to the existing literature.
Operational performance improvement in manual assembly lines: a case study in Denmark and conceptual model for quick and long-term wins
Authors: de Jesus Pacheco Diego Augusto , Schougaard Thomas 
Published: August 2023

PurposeThis study aims to investigate how to identify and address production levelling problems in assembly lines utilising an intensive manual workforce when higher productivity levels are urgently requested to meet market demands.Design/methodology/approachA mixed-methods approach was used in the research design, integrating case study analysis, interviews and qualitative/quantitative data collection and analysis. The methodology implemented also introduces to the literature on operational performance a novel combination of data analysis methods by introducing the use of the Natural Language Understanding (NLU) methods.FindingsFirst, the findings unveil the impacts on operational performance that transportation, limited documentation and waiting times play in assembly lines composed of an intensive workforce. Second, the paper unveils the understanding of the role that a limited understanding of how the assembly line functions play in productivity. Finally, the authors provide actionable insights into the levelling problems in manual assembly lines.Practical implicationsThis research supports industries operating assembly lines with intensive utilisation of manual workforce to improve operational performance. The paper also proposed a novel conceptual model prescriptively guiding quick and long-term improvements in intensive manual workforce assembly lines. The article assists industrial decision-makers with subsequent turnaround strategies to ensure higher efficiency levels requested by the market.Originality/valueThe paper offers actionable findings relevant to other manual assembly lines utilising an intensive workforce looking to improve operational performance. Some of the methods and strategies examined in this study to improve productivity require minimal capital investments. Lastly, the study contributes to the empirical literature by identifying production levelling problems in a real context.
How effort expectancy and performance expectancy interact to trigger higher education students’ uses of ChatGPT for learning
Authors: Duong Cong Doanh , Bui Duc Tho , Pham Huong Thao , Vu Anh Trong , Nguyen Van Hoang 
Published: August 2023

Purpose
The emergence of artificial intelligence technologies, like ChatGPT, has taken the world by storm, particularly in the education sector. This study aims to adopt the unified theory of acceptance and use of technology to explore how effort expectancy (EEC) and performance expectancy (PEE) individually, jointly, congruently and incongruently affect higher education students’ intentions and actual uses of ChatGPT for their learning.

Design/methodology/approach
An advanced methodology – polynomial regression with response surface analysis – and a sample of 1,461 higher education students recruited in Vietnam through three-phase stratified random sampling approach were adopted to test developed hypotheses.

Findings
Both EEC and PEE were found to have a direct positive impact on the likelihood of higher education students’ intention to use ChatGPT, which in turn promotes them actually use this tool for learning purposes. Conversely, a large incongruence between EEC and PEE will lower the level of intentions and actual uses of ChatGPT for learning. However, when there is a growing incongruence between EEC and PEE, either in a positive or negative direction, the likelihood of students’ intentions to use ChatGPT for learning decreases.

Practical implications
Some practical implications are subsequently recommended to obtain advantages and address potential threats arising from the implementation of this novel technology in the education context.

Originality/value
This study shed the new light on the educational setting by testing how higher education students’ intentions to use ChatGPT and subsequent actual uses of ChatGPT are synthesized from the balance between high EEC and PEE.
Does a name make a difference? The neo-documentalist movement, where does it stand after 27 years 1996–2023
Authors: Lund Niels Windfeld 
Published: August 2023

PurposeThe purpose of the paper is to analyze how the Neo-documentalist movement, initiated in 1996 by Michael Buckland, Boyd Rayward and Niels Lund, has evolved in its 27 years history, how the choice of documentation as name of the new program in Tromsø has made a difference in the LIS field and how different documentation scholars around the world has participated and approached the movement until now.Design/methodology/approachThe paper has approached the “Neo-documentalist movement” in a historical perspective from 1996 to 2023 discussing what difference does the choice of a concept make, when the concept of documentation is chosen instead of information in the name of a program and for the general discussion of the object of an academic field like Library and Information Science.FindingsThe analysis shows that it did make a difference to choose the concept of documentation as name of the program in Tromsø and the Neo-documentalist movement contributed to a new focus and discussion of the informative objects, the documents and their creation, not only in Tromsø, but in different parts of the world across linguistic borders.Originality/valueThe paper is original by the fact that it is the first time that the neo documentalist movement has been reviewed on a global scale across linguistic barriers. It has value by a discussion of the ways in which a choice of concept matter in relation to defining a field and the research agenda.
The effects of institutions, firm-level factors and rational decision-making on entrepreneurial behaviors of MSMEs: lessons and opportunities for transition communities
Authors: Kryeziu Liridon , Krasniqi Besnik A. , Bağış Mehmet , Hajrullahu Vjose , Zhushi Genc , Bytyçi Donika , Ismajli Mirsim 
Published: August 2023

Purpose
This study aims to examine the impact of regulatory, normative and cultural cognitive institutions and firm and individual factors on entrepreneurial behavior.

Design/methodology/approach
Using the quantitative research method, the authors collected data from 316 micro, small and medium enterprises (MSMEs) in Kosovo, a transition economy, through a cross-sectional research design. The authors performed exploratory factor analyses, correlation and regression analyses on the data using SPSS 26 and STATA software.

Findings
The research findings indicate that, within transition economies, normative and cultural-cognitive institutions have a positive impact on entrepreneurial behaviors. The authors could not determine the effect of regulatory institutions on entrepreneurial behavior. The authors also discovered that young firms are more inclined toward entrepreneurial behavior than older firms, and micro firms display a stronger entrepreneurial behavior than small firms. Furthermore, family businesses showed a greater tendency for entrepreneurial behavior than nonfamily firms. Interestingly, when the rational decision-making interacts with regulatory institutions, the effect on entrepreneurial behavior is negative.

Research limitations/implications
This study employed a cross-sectional approach to investigate the influence of macro, meso, and micro-level factors on entrepreneurial behavior within a transitioning community across three industries. Future studies could replicate these findings within comparable institutional contexts, employing longitudinal studies that include additional variables beyond those considered in our present study.

Practical implications
Considering the importance of MSMEs for a country’s economic and sustainable development, the authors provide some policy implications. The authors recommend managers carefully evaluate the information gathered while they decide and also increase their capabilities concerning digitalization, which is crucial for their firm’s survival, growth and sustainable competitive advantage.

Originality/value
This paper contributes to the literature and shows and analyses entrepreneurial behavior at institutional (macro), firm-level factors (meso) and managers' rational decision-making (micro), providing evidence from a transition community.
Real Estate Insights The clash of politics and economics in the UK property market–the case of leaseholds
Authors: Seagraves Philip 
Published: August 2023

PurposeThe aim of this Real Estate Insight is to comment upon the UK leasehold system, particularly focussing on new-build homes. This paper sheds light on the controversy surrounding this practice, public perception and the impact of a proposed ban on the housing and the impact, thereof, on property investment.Design/methodology/approachThis Real Estate Insight, through the lens of investment principles, dissects the rationale behind the initial pricing in the leasehold system and how potential future costs and benefits shape this mechanism. The nature of the “Insights” briefings means that this is a personal view of the author.FindingsWith the recent outcry over perceived unfair practices, the paper scrutinises whether the problem lies within the system itself or in the consumers' comprehension of the system. This paper suggests that enhancing consumer education and imposing stricter disclosure requirements might serve as a more effective solution than outright legislative prohibitions.Practical implicationsThe paper also briefly touches upon the concept of “gouging” in market function, highlighting potential inconsistencies in consumer behaviour.Originality/valueThis is a review of the UK leasehold market in relation to the legal title being offered at purchase.
Framing your concerns right: an analysis of air passengers' complaints during two time periods
Authors: Sharma Divya , Vimalkumar M. , Gouda Sirish , Gupta Agam , Ilavarasan Vignesh 
Published: August 2023

PurposeConsumers are increasingly choosing social media over other channels and mechanisms for grievance redressal. However, not all social media grievances elicit a response from businesses. Hence, in this research the authors aim to explore the effect of the complainant's social characteristics and the complaint's social and content characteristics on the likelihood of receiving a response to a grievance from the business on social media.Design/methodology/approachThe authors build a conceptual model and then empirically test it to explore the effect of the complainant's characteristics and the complaint's characteristics on the likelihood of response from a business on social media. The authors use data of consumer grievances received by an Indian airline operator on Twitter during two time periods – the first corresponding to lockdown during Covid-19 pandemic, and the second corresponding to the resumption of business as usual following these lockdowns. The authors use logistic regression and the hazard rate model to model the likelihood of response and the response delay, respectively, for social media customer grievances.FindingsComplainants with high social influence are not more likely to get a response for their grievances on social media. While tagging other individuals and business accounts in a social media complaint has negative effect on the likelihood of business response in both the time periods, the effect of tagging regulatory bodies on the likelihood of response was negative only in the Covid-19 lockdown period. The readability and valence of a complaint were found to positively affect the likelihood of response to a social media grievance. However, the effect of valence was significant only in lockdown period.Originality/valueThis research offers insights on what elicits responses from a service provider to consumers' grievances on social media platforms. The extant literature is a plenty on how firms should be engaging consumers on online media and how online communities should be built, but scanty on grievance redressal on social media. This research is, therefore, likely to be useful to service providers who are inclined to improve their grievance handling mechanisms, as well as, to regulatory authorities and ombudsmen.