bluuebunny/crossref_metadata_2025_split huggingface dataset:
Role of heparin-binding protein, glycocalyx in Sepsis-induced coagulopathy
Authors: Zhang Shaokang , Ma Shaolin , Liu Yang 
Published: April 2023

AbstractBackgroundTo explore the role of heparin-binding proteins released from glycocalyx and neutrophils in the mechanism of Sepsis-induced coagulopathy development. The therapeutic mechanism of Heparin in septic coagulation caused by Hparin-binding Protein and glycocalyx was studied by comparing the changes of Hparin-binding Protein and glycocalyx metabolites before and after heparin administration.MethodsPatients diagnosed with sepsis from November 2021 to November 2022 were selected and prospectively studied. Basic clinical data were collected and main indicators were detected for enrolled patients. Hparin-binding Protein and glycocalyx metabolites(HA、HS、SDC-1) were determined by ELISA kit. The main observation indexes were the changes of Hparin-binding Protein and glycocalyx metabolites in two groups before and after heparin administration.ResultsA total of 148 subjects were screened, and 80 met inclusion and exclusion criteria. Of these, 24 were in the SIC( Sepsis-induced coagulopathy) group and 56 were in the non-SIC group. The levels of HBP(Hparin-binding Protein) and glycocalyx metabolites in SIC group were higher than those in non-SIC group. After heparin treatment, the levels of HBP in SIC and non-sic groups were increased, and the levels of glycocalyx metabolites were decreased. Compared with the non-SIC group, patients in the SCI group had more significant increase in HBP level and decrease in glycocalyx metabolites.ConclusionPlasma HBP may affect blood coagulation and endothelial function on glycocalyx. Heparin may indirectly protects the glycocalyx by replacing the HBP that binds to the glycocalyx.
A Retrospective Chart Review Demonstrates that Coordinated, Multidisciplinary Treatment for Patients with Anorexia Nervosa Improves Odds of Weight Restoration
Authors: Woodruff Kary , Joy Elizabeth , Burns Ryan D. , Summers Scott A. , Metos Julie M. , Jordan Kristine C. 
Published: April 2023

Abstract

Background: Insufficient evidence exists to support the recommendation for coordinated, multidisciplinary care for the outpatient treatment of patients with anorexia nervosa. The objective of this study was to conduct a pragmatic assessment of care delivered through a retrospective comparative examination of patients who received a coordinated, multidisciplinary approach (medical provider, registered dietitian, and mental health professional collaborating to coordinate patient care) on clinical outcomes for treatment of anorexia nervosa (AN).Methods: Historical electronic medical record data on patients aged 6 to 80 years diagnosed with AN seen in a healthcare system between 2007 and 2017 were stratified, according to services received, into three groups: Group A (n = 48) received hospital-based services; Group B (n = 290) saw one or two provider types; Group C (n = 26) received outpatient coordinated multidisciplinary care from three provider types. Clinical outcomes (body mass index for adults, body mass index percentile for pediatric patients) defined AN severity and weight restoration. Electronic medical record data were analyzed using a generalized mixed-effects model and a Markov Transition model to examine the odds of weight restoration and the change in odds of weight restoration across the number of provider visits, respectively.Results: Patients receiving coordinated multidisciplinary care had significantly higher odds of weight restoration compared with patients receiving hospital-based services only (OR = 3.76, 95% CI [1.04, 13.54],p= 0.042). Additionally, patients receiving care from 1-2 providers (OR = 1.006, 95% CI [1.003, 1.010],p= 0.001) or receiving coordinated multidisciplinary care (OR = 1.005, 95% CI [1.001, 1.011],p= 0.021) had significantly higher odds of weight restoration per provider visit day.Conclusions: This retrospective chart review supports the coordinated, multidisciplinary care model for the outpatient treatment of AN.
Occupational burnout, job satisfaction and flourishing among healthcare workers in western China: a network analysis
Authors: Jia Siyan , Yu Bin , Feng Chuanteng , Jia Peng , Xu Peng , Yang Shujuan 
Published: April 2023

Abstract

BackgroundHealthcare workers suffered with high prevalence of occupational burnout, which might be related with their job satisfaction and well-being. This study aimed to provide evidence of complex interrelations among occupational burnout, job satisfaction, and flourishing, and identify key variables from the perspective of network structure among healthcare workers.MethodsA cross-sectional study was conducted between July and October 2021, and 922 healthcare workers were recruited to report their sociodemographic characteristics, occupational burnout, job satisfaction, and flourishing. Network analysis was conducted to investigate the interrelations of dimensions in occupational burnout, job satisfaction, and flourishing communities, and identify central variables and bridges connecting different dimensions with different bridge strength thresholds in the network structure. The Network Comparison Test (NCT) was conducted to examine the gender differences in networks.ResultsIn the network, feeling exhausted at work (strength: 1.42) and feeling frustrated at work (1.27) in occupational burnout community, and interested in daily activities (1.32) in flourishing community were central variables. Bridges in the network were job reward satisfaction (bridge strength: 0.31), satisfaction with job itself (0.25), and job environment satisfaction (0.19) in job satisfaction community, as well as interested in daily activities (0.29) and feeling respectable (0.18) in flourishing community, with bridges selected with top 20% bridge strengths. Feeling frustrated at work (0.14) in occupational burnout community and leading a purposeful and meaningful life (0.11) in flourishing community became bridges when using thresholds of top 25% and 30% bridge strengths, respectively. We also observed higher network densities in females (network density: 0.37) than that in males (0.34) and gender differences in the distribution of partial correlation coefficients (M = 0.27, P = 0.017).ConclusionsIn the network structure of occupational burnout-job satisfaction-flourishing, feeling frustrated at work in occupational burnout community and interested in daily activities in flourishing community were both central variables and bridges, which may be targeted variables to intervene to alleviate the overall level of symptoms in the network and therefore prevent poor health outcomes in healthcare workers.
Does Resilience and Social Support Moderate the Association between Race-Related Stress Black Women’s Reports of Trauma Symptoms?
Authors: Williams Tiffany R , Erving Christy L. , Gao Fanchen , Mitchell Taeja , Muwele Chomba , Martin Reniece , Blasingame Miaya 
Published: April 2023

Abstract

Black women uniquely experience a myriad of intersecting oppressions along with racial discrimination that increases their vulnerability to trauma. Experiences of racial discrimination manifest as race-related stress, or worse an emotional wound, race-related trauma. Protective factors that facilitate coping for Black women are resilience and social support. Under investigation were Black women’s experiences of racial stress, specifically, perseverative cognition (PC) and anticipatory race-related stress (ARRS), and trauma symptoms. PC and ARRS derive from the Prolonged Activation and Anticipatory Race-Related Stress Scale. The moderating effects of resilience and social support were also examined. Data were collected from 216 Black female students at a Historically Black University. The findings indicate (1) PC was associated with higher trauma symptoms (ß = 4.46; p < .001); (2) ARSS was positively associated with trauma symptoms (ß = 4.82; p < .001); (3) Social support (ß = -2.04; p < .001) and resilience (ß = -2.80; p < .05) moderated the association between ARRS and trauma symptoms such that the association between racial stress and trauma symptoms was stronger under the condition of low social support and resilience. Treatment must include culturally relevant interventions and capitalize on protective factors to facilitate healing for Black women.
Hydraulic characteristics optimization of an airfoil pillar-shaped flume based on the Hicks–Henne function and NSGA-II algorithm
Authors: Song Zhanqi , Yang Lei , Li Zhigang , Sun Bin 
Published: April 2023

Abstract

In order to improve the fine optimization technology of flow measurement facilities in irrigation areas, the hydraulic characteristics optimization system of an airfoil pillar-shaped flume is constructed. The optimization system integrates three modules of airfoil shape reconstruction by Hicks–Henne function, CFD numerical simulation calculation, and NSGA-II algorithm. It can efficiently find the shape design variable value that makes the hydraulic characteristics optimal. An example of the airfoil pillar-shaped flume in a rectangular channel at 30 L/s of discharge rate is given, and the specific optimization design concept of backwater height and head loss is presented. The results show that the backwater height is reduced by 9.49% compared with the prototype, and the head loss is reduced by 8.10% compared with the prototype, proving the feasibility of the optimization system. It can provide a theoretical reference for the optimization of hydraulic characteristics of similar measuring flumes.
A karst runoff generation module based on the near-surface critical zone structure and threshold behaviors
Authors: Zhao Jianfei , Li Guofang , Duan Yanan , Hu Yiming , Li Binquan , Liang Zhongmin 
Published: April 2023

Abstract

Hydrological simulation in karst areas is of great importance and challenge. It is a practical way to enhance the performance of existing hydrological models in karst areas by coupling karst modules that represent hydrological processes in these areas. The near-surface critical zone structure affects runoff generation in karst areas significantly and its complex hydrological processes could be simplified with threshold behaviors. This study proposed a three-thresholds-based karst runoff generation module (3T-KRGM), which used three reservoirs to represent water storage in the soil zone, soil–epikarst interface, and epikarst zone. The 3T-KRGM is coupled with the Xinanjiang (XAJ) model to extend the applicability of the model to karst areas. Both the improved XAJ model and the original XAJ model were used in the Shibantang watershed, which is a typical karst watershed located in southwest China. The results indicate that the performance of daily discharge simulations was obviously improved by introducing the 3T-KRGM. In addition, both the parameter sensitivity analysis and baseflow simulation demonstrate that the 3T-KRGM is rational in structure. The 3T-KRGM could also be easily coupled into other hydrological models, thus benefiting the hydrological simulation in karst areas.
Decision support system for selective withdrawal in water supply reservoirs: an approach based on thermal stratification
Authors: Soyer Elif , Bayram Haluk , Canıgeniş Nalan , Eren Onur 
Published: April 2023

Abstract

We consider the problem of determining water withdrawal depth in water supply reservoirs with multilevel intakes in an effective and systematic manner. In the traditional way, operators decide which intake port to use based on their own experience and water samples taken from various depths. Our goal is to provide assistance to operators in the decision-making process and establish a systematic approach for determining the appropriate water withdrawal level in a stratified reservoir. To achieve this, we propose an algorithmic approach as a decision support system for estimating the water withdrawal level. We validate our approach using long-term data collected from a water supply reservoir and compare the results with those of the operator's decisions. The results reveal that when the depth tolerance is set to 10 m, the approach and operator's decisions match at an 80% rate. However, when the depth tolerance is increased to 15 m, the matching percentage improves to over 90%.
Invenção de Natal
Authors: Araujo de Maria Anne Caroline , De Oliveira Tadeu 
Published: April 2023

Reconhecido internacionalmente por suas obras, a exemplo da sua pesquisa de doutoramento A invenção do Nordeste e outras artes (1999) e História: a arte de inventar o passado (2007), Durval Muniz de Albuquerque Junior concede uma entrevista de história oral sobre a construção social das espacialidades da cidade do Natal, capital do Rio Grande do Norte. No livro A invenção do Nordeste e outras artes, que foi fonte para a criação da peça teatral do grupo Carmin, Durval Albuquerque trouxe os mecanismos estéticos, históricos e culturais das primeiras décadas do século XX ,que contribuíram para a formação do nordeste como um espaço idealizado e deslocado do processo histórico. Nesta entrevista o historiador traça similaridades de uma construção da espacialidade de Natal, compondo a narrativa com elementos da política, do urbanismo e da cultura local.
Efficacy and safety of direct oral anticoagulants in children in real clinical practice
Authors: Yafoshkina T. Yu. , Shifrin Yu. A. , Fedorova D. V. , Florinskiy D. B. , Evstratov D. A. , Zharkov P. A. 
Published: April 2023

Introduction. As well as standard anticoagulants, direct oral anticoagulants (DOAC) have been approved for treatment of thromboembolism in children, recently. Several clinical trials provide promising data on efficacy and safety of DOAC in children and young adults. But further studies aimed at evaluating the efficacy and safety of these drugs in children and adolescents are still needed.The aim of the study is to evaluate the safety and effectiveness of the use DOACs in children.Materials and methods. We have retrospectively analyzed the medical records of patients (0–17 years) of from 2013 to 2022 at our tertiary care Centre and selected patients, who were treated with apixaban, rivaroxaban or dabigatran for more than 14 days. Patients with arterial thrombosis, children, who were treated with combined anticoagulant therapy and those who were unable for follow-up were excluded. We assessed the rates of bleeding and recurrent venous thromboembolism (VTE).Results. There were 67 patients, who were treated with DOAC in our center. Patients were divided into 2 groups: those, who received prophylactic anticoagulation (group 1 – 6 patients), and patients, who received DOAC therapy after venous thromboembolism (group 2 – 61 patients). The median follow-up time was 46 (25–365) days in the group 1, and 4 months (2 weeks – 36 month) in the group 2. There were no VTE episodes and 1 minor bleeding in group 1, while 1 (2 %) major, 4 (6 %) minor bleeding episodes in group 2. There were 4 (6 %) patients with recurrent VTE in group 2.Conclusion. The majority of patients in this study received rivaroxaban (79 %). We found a moderately increased recurrence rate of VTE, which could be the result of a long follow-up period, and a comparable rate of bleeding, all of which were associated with rivaroxaban therapy. In the future, of particular interest, in our opinion, are prospective studies of DOACs as primary antithrombotic prophylaxis, as well as secondary prophylaxis in the highest-risk groups, and the results of an analysis of their use in real clinical practice.
Approaches to the treatment of a multisystem form of juvenile xanthogranuloma with central nervous system lesion
Authors: Natrusova M. V. , Burtsev E. A. , Bronina N. V. , Osipova D. S. , Evseev D. A. , Seliverstova E. V. , Bronin G. O. , Maschan M. A. , Kumirova Е. V. 
Published: April 2023

Relevance. Juvenile xanthogranuloma (JXG) is the most common form of non-Langerhans cell histiocytic disorder. Cutaneous forms of the disease spontaneously regress within a few years, while systemic forms of JXG require treatment and may pose a threat to the lives of patients. Due to the lack of unified approach to the treatment of multisystem forms of JXG, the question of effective therapy tactics remains unresolved. The most common approach is to use Langerhans cell histiocytosis (LCH) treatment regimens for JXG. With the understanding of the leading role of mutations in the MEK-ERK signaling pathway in the pathogenesis of JXG, targeted therapy, BRAF- and MEK-inhibitors, are increasingly being considered in the treatment of JXG.Clinical cases. We present two cases of multisystem JXG with central nervous system (CNS) lesions. The first patient with CNS and skin lesions was treated with chemotherapy, developed for the treatment of multisystem LCH, which allowed us to obtain an effect “active disease better” (AD better). The second JXG patient with brain, lungs, bones, and adrenal gland lesions, combined targeted therapy with BRAF- and MEKinhibitors, vemurafenib and cobimetinib, resulted in a “non active disease” (NAD) effect.Conclusion. Multisystem form of JXG with CNS involvement is a rare oncological disease, the therapy of which has not been developed. With the introduction of molecular genetic profiling technology, it became possible to obtain NAD effect using targeted therapy.
Effectiveness of a Personalized, Chess-Based Training Serious Video Game in the Treatment of Adolescents and Young Adults With Attention-Deficit/Hyperactivity Disorder: Randomized Controlled Trial
Authors: Rodrigo-Yanguas María , Martín-Moratinos Marina , González-Tardón Carlos , Sanchez-Sanchez Fernando , Royuela Ana , Bella-Fernández Marcos , Blasco-Fontecilla Hilario 
Published: April 2023

Background
Compared with traditional approaches, gaming strategies are promising interventions for the treatment of attention-deficit/hyperactivity disorder (ADHD). We developed a serious game, The Secret Trail of Moon (TSTM), for ADHD treatment.

Objective
The main objective of this clinical trial was to demonstrate the effectiveness of an add-on, either TSTM or Therapeutic Chess (TC), in previously optimally drug-titrated, clinically stable patients with ADHD.

Methods
This study is a prospective, unicentric, randomized clinical trial in clinically stable patients with ADHD, aged 12 to 22 years. The TSTM (n=35) and TC groups (n=34) performed 12 weekly sessions of their respective treatments. The control group (CG) patients (n=35) were called by phone every week, but they received no cognitive intervention. The primary end point was the change from baseline to end point in the parent “Behavior Rating Inventory of Executive Function-2” (BRIEF-2; patients’ parents) in the per-protocol population (31 serious videogame: 24 TC and 34 CG).

Results
Our study failed to probe clear-cut improvements in the global score of the BRIEF-2. However, the TC group showed improvements in measures of emotional control, emotional regulation, and inattention. The TSTM group showed improvements in measures of emotional regulation, inattention, and school context.

Conclusions
TSTM and TC did not improve executive function symptoms, but they improved ADHD symptomatology related to emotional regulation. Further studies with bigger samples are required to confirm these preliminary findings.

Trial Registration
ClinicalTrials.gov NCT04355065; https://clinicaltrials.gov/ct2/show/NCT04355065
Pinceladas de historia - Contrapunto - Una experiencia educativa mediada con videojuegos
Authors: Santos Méndez Diego Julián , Pineda Romero Margarita María , Guerra Arango Carlos Fernando 
Published: April 2023

- “Pinceladas de Historia - Contrapunto” is a prototype of an electronic game to present in a graphic and animated way historical facts of our country and from them build critical thinking in children and young people who have access to it.
The video game was thought of as a necessity, since teaching history at school allows students to build conceptual perspectives.
Currently, students have lost interest in learning history, they see it as one more requirement of their educational program, which becomes an additional difficulty for the teachers who are in charge of taking the course. That is why Brushstrokes of History seeks to help break the stereotype regarding learning history and also promote knowledge of the most relevant events in our country.
Are Students Coming to Class Prepared? The Importance of Pre-Class Learning in a Flipped Classroom
Authors: Larson Melissa P. , Linnell Jace 
Published: April 2023

ABSTRACT
Despite extensive calls for the use of flipped classrooms in accounting, prior research has given little attention to the role of pre-class learning. Effective pre-class learning is essential to ensuring students still learn the basic class content that has been removed from a classroom to free up time for more active learning activities. If pre-class learning is not achieved, the value of the flipped classroom strategy is diminished. Through a review of existing literature, we provide accounting educators with a practical design guide for effectively implementing best-practices pre-class work in flipped classrooms. This article provides resources, design recommendations, and examples of flipped classroom implementation in an accounting education setting to foster more effective pre-class learning. We conclude with a call for research on various aspects of the flipped classroom in accounting education.
Tax Competition and Employment
Authors: Glaeser Stephen A. , Olbert Marcel , Werner Ann-Catherin 
Published: April 2023

ABSTRACT
We examine how exposure to international tax competition affects domestic firms’ employment. Consistent with prior work, we find evidence that reductions in foreign tax rates affect the domestic competitive environment via increases in import competition and investment in foreign-owned subsidiaries. We posit that these changes in the domestic competitive environment can cause managers to reduce their firms’ employment levels. Consistent with our expectation, we find that relative decreases in foreign tax rates negatively affect total labor compensation at domestic firms ex ante exposed to import competition and competition from foreign-owned peers. The effect of exposure to tax competition is greater for firms more exposed to product-market competition and those that are less able to expand investment without also increasing employment levels. Taken together, our results suggest that foreign tax rate changes can affect managers’ domestic employment decisions by changing the domestic competitive environment.
JEL Classifications: E24; F14; F16; H23; H35.