bluuebunny/crossref_metadata_2025_split huggingface dataset:
A scoping review protocol on integration of mobile-linked POC diagnostics in community-based healthcare: User experience
Authors: Nxele Siphesihle Robin , Moetlhoa Boitumelo , Kgarosi Kabelo , Mashamba-Thompson Tivani 
Published: February 2023

Background
Mobile-linked point-of-care diagnostics forms an integral part of diagnostic health services for efficient communication between patients and healthcare professionals despite geographical location and time of diagnosis. The efficiency of this technology lies in the user experience which means that the interaction of the user with the implemented technology needs to be simple, convenient, and consistent. Having a well-structured user experience of these devices in community-based healthcare will aid in sustainable implementation. Herein, we propose to conduct a literature search to systematically map out evidence based on mobile-linked POC diagnostics user experience at a community level in resource-limited settings.

Methodology
The proposed scoping review will be guided by the advanced Arksey and O’Malley methodological framework and further advanced by Levac et al. A comprehensive search will be conducted to find relevant published literature from the following electronic databases: Scopus, Web of Science, EBSCOhost (Medline, CINAHL, Africa-wide, Academic Search Complete). Grey literature will also be searched, including reports from government and international organizations such as World Health Organization (WHO), Foundation for Innovative New Diagnostics (FIND), and the Food and Drug Administration (FDA). Two independent reviewers will screen the relevant studies and the degree of the agreement will be determined by calculating Cohen’s kappa statistic. The quality of eligible data will also be appraised using the mixed method appraisal tool version 2018.

Discussion
We anticipate that the planned scoping review will present useful evidence to inform stakeholders on the integration of mobile-linked diagnostic devices in community-based healthcare which will guide further research on the subject.
Informing the development of diagnostic criteria for differential diagnosis of alcohol-related cognitive impairment (ARCI) among heavy drinkers: A systematic scoping review
Authors: Jones Lisa , Owens Lynn , Thompson Andrew , Gilmore Ian , Richardson Paul 
Published: February 2023

Background
Early detection and diagnosis of alcohol-related cognitive impairment (ARCI) among heavy drinkers is crucial to facilitating appropriate referral and treatment. However, there is lack of consensus in defining diagnostic criteria for ARCI. Uncertainty in attributing a diagnosis of suspected ARCI commonly arises in clinical practice and opportunities to intervene are missed. A systematic scoping review approach was taken to (i) summarise evidence relating to screening or diagnostic criteria used in clinical studies to detect ARCI; and (ii) to determine the extent of the research available about cognitive assessment tools used in ‘point-of-care’ screening or assessment of patients with suspected non-Korsakoff Syndrome forms of ARCI.

Methods
We searched Medline, PsycINFO, Cinahl and the Web of Science, screened reference lists and carried out forward and backwards citation searching to identify clinical studies about screening, diagnosis or assessment of patients with suspected ARCI.

Results
In total, only 7 studies met our primary objective and reported on modifications to existing definitions or diagnostic criteria for ARCI. These studies revealed a lack of coordinated research and progress towards the development and standardisation of diagnostic criteria for ARCI. Cognitive screening tools are commonly used in practice to support a diagnosis of ARCI, and as a secondary objective we included an additional 12 studies, which covered a range of settings and patient populations relevant to screening, diagnosis or assessment in acute, secondary or community ‘point-of-care’ settings. Across two studies with a defined ARCI patient sample and a further four studies with an alcohol use disorder patient sample, the accuracy, validity and/or reliability of seven different cognitive assessment tools were examined. The remaining seven studies reported descriptive findings, demonstrating the lack of evidence available to draw conclusions about which tools are most appropriate for screening patients with suspected ARCI.

Conclusion
This review confirms the scarcity of evidence available on the screening, diagnosis or assessment of patients with suspected ARCI. The lack of evidence is an important barrier to the development of clear guidelines for diagnosing ARCI, which would ultimately improve the real-world management and treatment of patients with ARCI.
Clinical phenotypes of older adults with non-valvular atrial fibrillation not treated with oral anticoagulants by hierarchical cluster analysis in the ANAFIE Registry
Authors: Suzuki Shinya , Yamashita Takeshi , Akao Masaharu , Atarashi Hirotsugu , Ikeda Takanori , Okumura Ken , Koretsune Yukihiro , Shimizu Wataru , Tsutsui Hiroyuki , Toyoda Kazunori , Hirayama Atsushi , Yasaka Masahiro , Yamaguchi Takenori , Teramukai Satoshi , Kimura Tetsuya , Morishima Yoshinori , Takita Atsushi , Inoue Hiroshi 
Published: February 2023

Background
Although anticoagulants are indicated for many elderly patients with non-valvular atrial fibrillation (NVAF), some patients do not receive anticoagulant therapy, whose characteristics and outcomes are diverse.

Methods and results
In this sub-analysis of the All Nippon AF In the Elderly (ANAFIE) Registry, the phenotypes of patients who were not receiving anticoagulants at baseline were evaluated by cluster analysis using Ward’s linkage hierarchical algorithm. Of 32,275 enrolled patients, 2445 (7.6%) were not receiving anticoagulants. Two clusters were identified: (1) elderly paroxysmal AF (PAF) patients with a high proportion of catheter ablation history (57%) and (2) very elderly patients with a high prevalence of previous major bleeding (43%). Respective mean ages were 80.9 and 84.2 years, mean CHA2DS2-VASc scores were 3.8 and 4.9, PAF prevalences were 100.0% and 31.4%, proportions of patients with catheter ablation history were 21.0% and 7.9%, and proportions of patients with a history of major bleeding were 4.0% and 10.8%. Annual incidence rates were 2.72% and 8.81% for all-cause death, 1.66% and 5.85% for major adverse cardiovascular or neurological events, 1.08% and 3.30% for stroke or systemic embolism, and 0.69% and 1.19% for major bleeding, respectively.

Conclusions
In this cohort of elderly NVAF patients from the ANAFIE Registry who were not receiving anticoagulants, over half had PAF with a high proportion of catheter ablation history and a low incidence of adverse outcomes; for them, non-prescription of anticoagulants may be partially understandable, but they should be carefully monitored regarding AF burden or atrial cardiomyopathy and be adequately anticoagulated when adverse findings are detected. The remaining were very elderly patients with a high prevalence of previous major bleeding and a high incidence of adverse outcomes; for them, non-prescription of anticoagulants is inappropriate because of the high thromboembolic risk.

Trial registration
Registration: http://www.umin.ac.jp/; Unique identifier: UMIN000024006.
Effect on physiological parameters and anaesthetic dose requirement of isoflurane when tramadol given as a continuous rate infusion vs a single intravenous bolus injection during ovariohysterectomy in dogs
Authors: Costa Giovanna L. , Di Pietro Simona , Interlandi Claudia , Leonardi Fabio , Macrì Daniele , Ferrantelli Vincenzo , Macrì Francesco 
Published: February 2023

Background
Tramadol produces a significant reduction in both sevoflurane and isoflurane minimum alveolar concentrations in dogs under experimental conditions. This study aims to compare the effects of tramadol administered as a constant rate infusion (CRI) with those of tramadol administered as a single intravenous bolus on physiological parameters and isoflurane requirements in dogs undergoing ovariohysterectomy.

Methods
In this study, forty female dogs undergoing ovariohysterectomy were enrolled. The bitches were anesthetized with 5 mg/kg of tiletamine/zolazepam combined with 0.05 mg/kg of acepromazine intravenously. Anesthesia was maintained with isoflurane delivered in 100% oxygen. The group A (n = 20) received tramadol 4 mg/kg in a single intravenous bolus, whereas the group B (n = 20) received tramadol 1.5 mg/kg in an intravenous bolus followed by tramadol 2.6 mg/kg/h as a CRI. The following parameters were recorded: heart rate, respiratory rate, non-invasive blood pressure, body temperature, EtCO2, SpO2 and inspired and expired concentrations of isoflurane. Parameter measurements were performed from pre-preedication (baseline) to skin suturing.

Results
The dogs were healthy subjects that demonstrated no abnormalities on laboratory investigations. Significant tachycardia was recorded after administration of tiletamine/zolazepam combined with acepromazine in both groups. Heart rate decreased after intubation but remained significantly higher compared to baseline values in both groups. Systolic blood pressure significantly decreased in both groups but the recorded values were within the physiological range. Mild reduction in body temperature was recorded in both groups. SpO2 and EtCO2 remained within the physiological range. Isoflurane requirement was significantly lower in the group B compared to the group A. Transient twitching was recorded in two dogs belonging to the group A after tramadol administration.

Conclusions
Compared to tramadol given as a single intravenous bolus injection during ovariohysterectomy in dogs, tramadol administered as a CRI reduces isoflurane requirements in dogs anesthetized with tiletamine/zolazepam combined with acepromazine. Both tramadol given as a CRI and a single intravenous bolus injection, induce decrease in heart rate, respiratory rate and in body temperature but the values of these parameters remain within physiological range in dogs undergoing ovariohysterectomy.
The transcript interactome of skeletal muscle RNA binding protein motif 3 (RBM3)
Authors: Hettinger Zachary R. , Confides Amy L. , Vanderklish Peter W. , Dupont‐Versteegden Esther E. 
Published: February 2023

AbstractPost‐transcriptional regulation of gene expression represents a critical regulatory step in the production of a functional proteome. Elevated expression of post‐transcriptional regulator RNA binding motif protein 3 (RBM3), an RNA binding protein in the cold‐shock family, is positively correlated with skeletal muscle growth in adult mice. However, mechanisms through which RBM3 exerts its effects are largely unknown. The purpose of this study was to perform RNA immunoprecipitation followed by RNA sequencing (RIP‐seq) and apply a network science approach to understand biological processes (BPs) most associated with RBM3‐bound mRNAs. In addition, through nucleotide‐sequence‐scanning of enriched transcripts, we predicted the motif for skeletal muscle RBM3 binding. Gene set enrichment analysis followed by enrichment mapping of RBM3‐bound transcripts (fold change >3; p.adj <0.01) revealed significant enrichment of BPs associated with “Contractile apparatus,” “Translation initiation,” and “Proteosome complex.” Clusters were driven largely by enrichment of Myh1 (FC: 4.43), Eif4b (FC: 5.03), and Trim63 (FC: 5.84), respectively. Motif scanning of enriched sequences revealed a discrete 14 nucleotide‐wide motif found most prominently at the junction between the protein coding region's termination sequence and the start of the 3′ untranslated region (UTR; E‐Value: 1.1 e−015). Proof of concept investigation of motif location along enriched transcripts Myh1 and Myl4 revealed 3′ UTR binding, suggesting RBM3 involvement in transcript half‐life regulation. Together, these results demonstrate the potential influence of RBM3 in reshaping the skeletal muscle proteome through post‐transcriptional regulation of mRNAs crucial to muscle adaptations.
Corioamnionitis por Ureaplasma parvum: a propósito de un caso
Authors: Moreno-Flores Antonio , Domínguez-Landesa María , Vázquez-López María Guadalupe , Sante-Fernández Laura 
Published: February 2023

Resumen

Objetivos
Las especies de Ureaplasma son los microorganismos más frecuentemente relacionados con casos de parto prematuro espontáneo, rotura prematura de membranas o corioamnionitis.

Caso clínico
Gestante de 28 + 6 semanas, sin antecedentes personales de interés, que acude al hospital por contracciones. Ante la sospecha clínica de corioamnionitis ingresa para cesárea segmentaria transversa, transcurriendo sin nada reseñable y siendo dada de alta a los siete días del ingreso. El neonato permanece estable y sin datos clínicos de infección. No obstante, ante la sospecha clínica de corioamnionitis se pauta tratamiento empírico con ampicilina (2 g/6 h) y gentamicina (5 mg/kg/24 h) intravenosas y se toman muestras de exudados faríngeo/amigdalar, ótico y anal/rectal. A las 24 horas se detecta en todas las muestras Ureaplasma parvum, suspendiéndose el tratamiento empírico e iniciando azitromicina intravenosa (12 mg/24 h). También se detecta U. parvum en muestra de exudado endocervical y de placenta. Tras 52 días de ingreso el lactante es dado de alta.

Conclusiones
Aunque parece clara la relación entre la colonización por estos microorganismos y el desarrollo de enfermedad perinatal, el elevado porcentaje de colonización vaginal existente y el hecho de que la mayoría de embarazadas colonizadas den a luz a término, sin ningún tipo de complicación, hacen necesarios más estudios.
Synthetic pathway of 2-fluoro-N,N-diphenylbenzamide with opto-electrical properties: NMR, FT-IR, UV-Vis spectroscopic, and DFT computational studies of the first-order nonlinear optical organic single crystal
Authors: Raveendiran C. , Prabukanthan P. , Madhavan J. , Vivekanand P. A. , Arumugam Natarajan , Almansour Abdulrahman I. , Kumar Raju Suresh , Alaqeel Shatha Ibrahim , Perumal Karthikeyan 
Published: February 2023

Abstract
2-Fluoro-N,N-diphenylbenzamide (2FNNDPBA), a natural nonlinear optical (NLO) single crystal, was incorporated from diphenylamine utilizing 2-fluoro benzoyl chloride as a side chain. The single crystals were successfully developed by a slothful evaporation arrangement approach utilizing ethyl acetate as a dissolvable solvent at room temperature. The synthesized compound fragmented ion peak (m/z = 291) was affirmed by gas-chromatographic mass spectrometry investigation. The unit cell dimensions were assessed using single-crystal X-ray diffraction analysis, which reveals that the crystals possess the orthorhombic system with space group Pbca. The existence of proton and carbon in a compound was affirmed by 1H and 13C nuclear magnetic resonance. The functional groups therein of 2FNNDPBA have been identified from FT-IR and FT-Raman studies and amide carbonyl stretching frequency peak appeared at 1,662 cm−1. The lower cut-off wavelength of 2FNNDPBA is found to be 240 nm and the experimental and theoretical optical band gap was calculated as 3.21 and 3.1083 eV. The UV-Visible spectrum of 2FNNDPBA shows two high-flying peaks at 240 and 273 nm. Major weight losses were observed between 160°C and 275°C for the designated compound. The thermal property for 2FNNDPBA was estimated by thermogravimetric analysis/differential thermal analysis investigation, which shows immense thermal strength up to 171°C. Density functional theory method with Gaussian 09 software for theoretical investigations of 2FNNDPBA for Mulliken charge analysis, highest occupied molecular orbital–lowest-lying unoccupied molecular orbital, and molecular electrostatic potential properties has been analyzed. The SHG productivity was proved by Kurtz-Perry powder strategy and has an efficiency 2.22 times that of standard potassium dihydrogen phosphate. The laser damage threshold of 2FNNDPBA crystals was discovered to be 1.18 GW·cm−2. The hyperpolarizability simulations further show that the current material has an excellent NLO activity tendency. The melting point of the developed crystal is 158°C.
Adaptive normalization for IPW estimation
Authors: Khan Samir , Ugander Johan 
Published: February 2023

Abstract
Inverse probability weighting (IPW) is a general tool in survey sampling and causal inference, used in both Horvitz–Thompson estimators, which normalize by the sample size, and Hájek/self-normalized estimators, which normalize by the sum of the inverse probability weights. In this work, we study a family of IPW estimators, first proposed by Trotter and Tukey in the context of Monte Carlo problems, that are normalized by an affine combination of the sample size and a sum of inverse weights. We show how selecting an estimator from this family in a data-dependent way to minimize asymptotic variance leads to an iterative procedure that converges to an estimator with connections to regression control methods. We refer to such estimators as adaptively normalized estimators. For mean estimation in survey sampling, the adaptively normalized estimator has asymptotic variance that is never worse than the Horvitz–Thompson and Hájek estimators. Going further, we show that adaptive normalization can be used to propose improvements of the augmented IPW (AIPW) estimator, average treatment effect (ATE) estimators, and policy learning objectives. Appealingly, these proposals preserve both the asymptotic efficiency of AIPW and the regret bounds for policy learning with IPW objectives, and deliver consistent finite sample improvements in simulations for all three of mean estimation, ATE estimation, and policy learning.
Expanding the Australia Group’s chemical weapons precursors control list with a family-based approach
Authors: Costanzi Stefano , Koblentz Gregory D. , Cupitt Richard T. 
Published: February 2023

Abstract
The Australia Group (AG) is a forum of like-minded states seeking to harmonize export controls to prevent the proliferation of chemical and biological weapons. The AG Chemical Weapons Precursors list features dual-use chemicals that can be used as precursors for the synthesis of chemical weapons, all individually enumerated. This is in contrast with the Chemical Weapons Convention (CWC) Schedules, which, alongside entries describing discrete chemicals, also include entries that describe families of chemicals. By using families of chemicals, the CWC achieves the objective of covering with a single entry a wide array of related chemicals of concern, including chemicals that have not yet been made. There are practical reasons why the AG Chemical Weapons Precursors list is exclusively based on the enumeration of individual chemicals. A cheminformatics tool of which we have developed a prototype, the Nonproliferation Compliance Cheminformatics Tool (NCCT), has the potential to enable export control officers to handle control lists that contain families of chemicals. Thus, it opens the way to expand the AG Chemical Weapons Precursors list to a family-based approach for some of its entries. Such a change would result in a closer alignment of the chemical space covered by the AG Chemical Weapons Precursors list with that covered by the CWC Schedules, thus closing loopholes that could be exploited by proliferators.
Fatigue crack growth analysis in polymeric materials
Authors: Sadananda Kuntimaddi , Iyyer Nagaraja , Vasudevan Asuri K. , Nani Babu Matcha 
Published: February 2023

Abstract
Fatigue crack growth in polymers is analyzed using the two-parametric approach. Polymers deform by crazing, viscoelastic deformation, or brittle fracture, contributing to crack growth. The analysis shows that irrespective of the nature of the deformation of the material ahead of the crack tip, the crack growth rate data can still be represented by the L-shaped curves in the ΔK–K
max plane defining two limiting variables ΔK* and K
max
*. Thus, as in metals and alloys, the L-shaped curves depict the intrinsic fatigue behavior. The analysis further confirms that the load ratio effects in all materials are intrinsic to fatigue. A simple method for the prediction of these L-shaped fatigue curves is proposed.
Timbre Semantic Associations Vary Both Between and Within Instruments
Authors: Reymore Lindsey , Noble Jason , Saitis Charalampos , Traube Caroline , Wallmark Zachary 
Published: February 2023

The main objective of this study is to understand how timbre semantic associations—for example, a sound’s timbre perceived as bright, rough, or hollow—vary with register and pitch height across instruments. In this experiment, 540 online participants rated single, sustained notes from eight Western orchestral instruments (flute, oboe, bass clarinet, trumpet, trombone, violin, cello, and vibraphone) across three registers (low, medium, and high) on 20 semantic scales derived from Reymore and Huron (2020). The 24 two-second stimuli, equalized in loudness, were produced using the Vienna Symphonic Library.
Exploratory modeling examined relationships between mean ratings of each semantic dimension and instrument, register, and participant musician identity (“musician” vs. “nonmusician”). For most semantic descriptors, both register and instrument were significant predictors, though the amount of variance explained differed (marginal R2). Terms that had the strongest positive relationships with register include shrill/harsh/noisy, sparkling/brilliant/bright, ringing/long decay, and percussive. Terms with the strongest negative relationships with register include deep/thick/heavy, raspy/grainy/gravelly, hollow, and woody. Post hoc modeling using only pitch height and only register to predict mean semantic rating suggests that pitch height may explain more variance than does register. Results help clarify the influence of both instrument and relative register (and pitch height) on common timbre semantic associations.
Clinical Pathways for the Identification and Referral for Social Needs: A Systematic Review
Authors: Wong-See Harmonie , Calik Anna , Ostojic Katarina , Raman Shanti , Woolfenden Susan 
Published: February 2023

CONTEXT
Recognition of the importance of the social determinants of child health has prompted increased interest in clinical pathways that identify and refer for social needs.

OBJECTIVE
The aim of this systematic review was to determine the effectiveness of interventions that identify and refer for social needs for families with children aged 0 to 18 years attending outpatient community and ambulatory healthcare services.

DATA SOURCES
We searched the following databases: Medline, Embase, PsychINFO, CINAHL, Emcare, EBMR.

STUDY SELECTION
Studies were included if children and their families underwent a process of identification and referral for social needs in outpatient community and ambulatory healthcare services.

DATA EXTRACTION
Initial searches identified 5490 titles, from which 18 studies (73 707 families and children) were finally retained.

RESULTS
Intervention pathways were grouped into 3 categories based on whether identification and referral for social needs was conducted with only targeted community resources, a navigator, or with clinician training. The majority of studies reported positive outcomes; with an increase in social needs identification, an increase in referrals following identification, or a reduction in social needs. Child health outcome results were inconsistent.

LIMITATIONS
The search terms used may have provided bias toward countries in which these terms are in use. The heterogeneity of outcome measures between included studies meant a meta-analysis was not possible.

CONCLUSIONS
Despite evidence that clinical pathways for children and families help reduce social needs, evidence for improvements in child health is insufficient. Further studies from diverse settings are needed to inform clinical practice to optimize child health outcomes.