bluuebunny/crossref_metadata_2025_split huggingface dataset:
Advances in molecular targeted therapies to increase efficacy of (chemo)radiation therapy
Authors: Viktorsson Kristina , Rieckmann Thorsten , Fleischmann Maximilian , Diefenhardt Markus , Hehlgans Stephanie , Rödel Franz 
Published: April 2023

AbstractRecent advances in understanding the tumor’s biology in line with a constantly growing number of innovative technologies have prompted characterization of patients’ individual malignancies and may display a prerequisite to treat cancer at its patient individual tumor vulnerability. In recent decades, radiation- induced signaling and tumor promoting local events for radiation sensitization were explored in detail, resulting the development of novel molecular targets. A multitude of pharmacological, genetic, and immunological principles, including small molecule- and antibody-based targeted strategies, have been developed that are suitable for combined concepts with radiation (RT) or chemoradiation therapy (CRT). Despite a plethora of promising experimental and preclinical findings, however, so far, only a very limited number of clinical trials have demonstrated a better outcome and/or patient benefit when RT or CRT are combined with targeted agents. The current review aims to summarize recent progress in molecular therapies targeting oncogenic drivers, DNA damage and cell cycle response, apoptosis signaling pathways, cell adhesion molecules, hypoxia, and the tumor microenvironment to impact therapy refractoriness and to boost radiation response. In addition, we will discuss recent advances in nanotechnology, e.g., RNA technologies and protein-degrading proteolysis-targeting chimeras (PROTACs) that may open new and innovative ways to benefit from molecular-targeted therapy approaches with improved efficacy.
Is consolidative thoracic radiotherapy of extensive-stage small cell lung cancer still beneficial in the era of immunotherapy? A retrospective analysis
Authors: Hoffmann Elgin , De-Colle Chiara , Potkrajcic Vlatko , Baumann David , Spengler Werner , Gani Cihan , Utz David 
Published: April 2023

Abstract
Purpose
Extensive-stage small cell lung cancer (ES-SCLC) carries a dismal prognosis. The benefit of consolidative thoracic radiotherapy (TR) after first-line chemoimmunotherapy with PD-L1 inhibitors in this setting remains unclear. As TR can improve overall survival (OS) after conventional chemotherapy, we retrospectively analyzed OS of an inhouse cohort treated either with TR or with chemoimmunotherapy alone.

Methods
A total of 41 patients treated with chemoimmunotherapy with PD-L1 inhibitors (atezolizumab or durvalumab) for ES-SCLC at our hospital since 2019 were analyzed. TR was administered in 10 fractions of 3 Gy. Patient characteristics, number of immunotherapy cycles received, brain irradiation, and presence of hepatic and cerebral metastasis at diagnosis were assessed. Primary endpoint was OS after first diagnosis.

Results
Consolidative TR was associated with a significantly longer OS than systemic therapy alone (1-year OS 78.6% and 2‑year OS 37.1% vs. 1‑year OS 39.7% and 2 years not reached, p = 0.019). With regard to radiotherapy indication, survival at 1 year was 88.9% (log-rank p = 0.016) for patients receiving consolidative TR. For patients receiving TR in case of progression, 1‑year survival was 66.7%. Hepatic and cerebral metastasis at first diagnosis had no significant effect on OS.

Conclusion
TR was significantly associated with longer OS. The survival benefit of TR was most pronounced for consolidative radiotherapy after initial chemoimmunotherapy compared to TR in case of progression. Although retrospective findings need to be interpreted with caution, in the absence of prospective data, our findings provide a basis for offering consolidative TR in the era of chemoimmunotherapy.
A two-step methodology for product platform design and assessment in high-variety manufacturing
Authors: Bortolini Marco , Calabrese Francesca , Galizia Francesco Gabriele , Regattieri Alberto 
Published: April 2023

AbstractThe delayed product differentiation (DPD) recently rose as a hybrid production strategy able to overcome the main limits of make to stock (MTS) and make to order (MTO), guaranteeing the management of high variety and keeping low storage cost and quick response time by using the so-called product platforms. These platforms are a set of sub-systems forming a common structure from which a set of derivative variants can be efficiently produced. Platforms are manufactured and stocked following an MTS strategy. Then, they are customized into different variants, following an MTO strategy. Current literature proposes methods for platform design mainly using optimization techniques, which usually have a high computational complexity for efficiently managing real-size industrial instances in the modern mass customization era. Hence, efficient algorithms need to be developed to manage the product platforms design for such instances. To fill this gap, this paper proposes a two-step methodology for product platforms design and assessment in high-variety manufacturing. The design step involves the use of a novel modified algorithm for solving the longest common subsequence (LCS) problem and of the k-medoids clustering for the identification of the platform structure and the assignment of the variants to the platforms. The platforms are then assessed against a set of industrial and market metrics, i.e. the MTS cost, the variety, the customer responsiveness, and the variants production cost. The evaluation of the platform set against such a combined set of drivers enhancing both company and market perspectives is missing in the literature. A real case study dealing with the manufacturing of a family of valves exemplifies the efficiency of the methodology in supporting companies in managing high-variety to best balance the proposed metrics.
Comparative Transcriptomic and Proteomic Analyses Provide New Insights into the Tolerance to Cyclic Dehydration in a Lichen Phycobiont
Authors: del Campo Eva M. , Gasulla Francisco , Hell Aline F. , González-Hourcade María , Casano Leonardo M. 
Published: April 2023

AbstractDesiccation tolerance (DT) is relatively frequent in non-vascular plants and green algae. However, it is poorly understood how successive dehydration/rehydration (D/R) cycles shape their transcriptomes and proteomes. Here, we report a comprehensive analysis of adjustments on both transcript and protein profiles in response to successive D/R cycles in Coccomyxa simplex (Csol), isolated from the lichen Solorina saccata. A total of 1833 transcripts and 2332 proteins were differentially abundant as a consequence of D/R; however, only 315 of these transcripts/proteins showed similar trends. Variations in both transcriptomes and proteomes along D/R cycles together with functional analyses revealed an extensive decrease in transcript and protein levels during dehydration, most of them involved in gene expression, metabolism, substance transport, signalling and folding catalysis, among other cellular functions. At the same time, a series of protective transcripts/proteins, such as those related to antioxidant defence, polyol metabolism and autophagy, was upregulated during dehydration. Overall, our results show a transient decrease in most cellular functions as a result of drying and a gradual reactivation of specific cell processes to accommodate the hydration status along successive D/R cycles. This study provides new insights into key mechanisms involved in the DT of Csol and probably other dehydration-tolerant microalgae. In addition, functionally characterising the high number of genes/proteins of unknown functions found in this study may lead to the discovery of new DT mechanisms.
Diverse skill of seasonal dynamical models in forecasting South Asian monsoon precipitation and the influence of ENSO and IOD
Authors: Stacey J. , Salmon K. , Janes T. , Colman A. , Colledge F. , Bett P. E. , Srinivasan G. , Pai D. S. 
Published: April 2023

AbstractThe South Asia Seasonal Climate Outlook Forum (SASCOF) issues seasonal tercile precipitation forecasts to provide advance warning of anomalously dry or wet monsoon seasons in South Asia. To increase objectivity of the SASCOF seasonal outlook, the World Meteorological Organisation recommends using a multi-model ensemble combining the most skilful dynamical seasonal models for the region. We assess the skill of 12 dynamical models at forecasting seasonal precipitation totals for 1993–2016 for the southwest (June–July–August–September) and northeast (October–November–December) monsoon seasons at regional and national levels for Afghanistan, Bangladesh, Nepal, and Pakistan, using identical forecast periods, hindcast initialisation months and domain used at the SASCOF. All models demonstrate positive skill when regionally-averaged, especially for the southwest monsoon season, noting considerable spatial differences. Models exhibit highest skill where correlation between observed precipitation and El Niño Southern Oscillation (ENSO) is highest, e.g., central/north India and Nepal during the southwest monsoon, and Afghanistan and north Pakistan during the northeast monsoon. Model skill is especially low in northwest India and northeast of South Asia during the southwest monsoon, e.g., Bangladesh (despite high precipitation totals) coinciding with a weak ENSO teleconnection. The Indian Ocean Dipole teleconnection is less pronounced in the southwest monsoon season, whereas the spatial pattern for the northeast monsoon closely resembles that of ENSO. Due to high variability in model skill, we recommend basing the SASCOF forecast on a multi-model ensemble of all models but discounting poorly performing models at the national level.
Clinical application of enhanced recovery after surgery concept in laparoscopic treatment of pediatric acute appendicitis
Authors: Zhang Shao-Min , Chen Jie , Li Hui , Guo Meng-Fu , Han Nuan , Sun Jin-Song , Zhang Chong-Fang , Su Lin 
Published: April 2023

Abstract
Background
This study assesses whether enhanced recovery after surgery (ERAS) is beneficial in treating acute appendicitis in pediatrics by laparoscopic techniques.

Method
The children with acute appendicitis (n = 116) were divided into the ERAS group (n = 54) and the control group (n = 62). Then the preoperative data, intraoperative observation indexes, and postoperative data were analyzed.

Results
There was no significant difference in preoperative data and intraoperative observation indexes between the two groups. C-reactive protein (CRP) and white blood cell (WBC) in the ERAS group were significantly lower than those in the control group 3 days after the operation. Moreover, no significant difference in the visual analog score (VAS) between the two groups 3 days after the operation, but the other postoperative observation indexes in the ERAS group were significantly better than those in the control group. Nausea and vomiting in the ERAS group were significantly lower than those in the control group, with no significant difference in other complications between the two groups.

Conclusion
ERAS could improve children’s comfort, reduce some postoperative complications, reduce hospitalization expenses, and speed up recovery from acute appendicitis treated by laparoscopy. Therefore, it has clinical application value.
One-dimensional array of nanoparticles using segmented polyurethane nanofibers as a template for enhanced catalytic efficiency
Authors: Meboso Taichi , Goto Satoshi , Takamura Eiichiro , Sakamoto Hiroaki 
Published: April 2023

AbstractMetal nanoparticles are used to catalyze chemical reactions. Among them, noble metal nanoparticle catalysts need to be used in small quantities. Some reports reveal catalytic activity is further improved by controlling nanoparticle arrangement and distribution. Much research has been directed toward the formation of one-dimensional arrays by compositing metal nanoparticles with template materials. However, previously reported methods form arrays that lack linearity or suitable interparticle distances, which is ascribable to array crossover and particle aggregation, in addition their fabrication procedures are expensive and not suitable for large-scale practical use. Here we show that one-dimensional arrays of platinum nanoparticles (PtNPs) were formed by using electrospun polyurethane nanofibers as a template. PtNPs adsorbed on each polyurethane nanofiber form a one-dimensional array over longer distances. The catalytic H2O2 decomposition performance of the prepared one-dimensional PtNP arrays was 45.6% decomposition in 15 min, which revealed a decomposition rate more than twice that obtained using the same number of PtNPs randomly distributed on the template or dispersed in a liquid. Although this method is a very simple method for one-dimensional arrangement of metal nanoparticles, thereby improving catalytic efficiency per metal nanoparticle, which help to reduce the amount of metal nanoparticles used during catalysis and contributes the cost of catalysis products cost.
Multiple loci with cumulative effects on late maturity α-amylase (LMA) in wheat
Authors: Mares Daryl , Derkx Adinda , Mather Diane E. , Cheong Judy , Mrva Kolumbina 
Published: April 2023

Abstract
Main conclusion
The cumulative action of combinations of alleles at several loci on the wheat genome is associated with different levels of resistance to late maturity α-amylase in bread wheat.

Abstract
Resistance to late maturity α-amylase (LMA) in bread wheat (Triticum aestivum L.) involves a complex interaction between the genotype and the environment. Unfortunately, the incidence and severity of LMA expression is difficult to predict and once the trait has been triggered an unacceptably low falling number, high grain α-amylase may be the inevitable consequence. Wheat varieties with different levels of resistance to LMA have been identified but whilst some genetic loci have been reported, the mechanisms involved in resistance and the interaction between resistance loci requires further research. This investigation was focused on mapping resistance loci in populations derived by inter-crossing resistant wheat varieties or crossing resistant lines with a very susceptible line and then mapping quantitative trait loci. In addition to the previously reported locus on chromosome 7B for which a candidate gene has been proposed, loci were mapped on chromosomes 1B, 2A, 2B, 3A, 3B, 4A, 6A and 7D. These loci have limited effects on their own but have a cumulative effect in combination with each other. Further research will be required to determine the nature of the causal genes at these loci, to develop diagnostic markers and determine how the genes fit into the pathway that leads to the induction of α-AMY1 transcription in the aleurone of developing wheat grains. Depending on the target environmental conditions, different combinations of alleles may be required to achieve a low risk of LMA expression.
A deeper look into the functions of right ventricle using three-dimensional echocardiography: the forgotten ventricle in children with systemic lupus erythematosus
Authors: Rakha Shaimaa , Hammad Ayman , Elmarsafawy Hala , Korkor Mai S. , Eid Riham 
Published: April 2023

Abstract
Studies on the right ventricular dysfunction (RV) in systemic lupus erythematosus (SLE) patients are limited, particularly in the pediatric age group. The study aimed to identify subclinical RV alterations in childhood-onset SLE (c-SLE) using conventional and three-dimensional echocardiography (3DE). Forty SLE pediatric patients and 40 healthy controls were included. Disease activity and chronicity were evaluated by SLE disease activity index (SLEDAI) score and SLE damage index (SDI). Participants underwent detailed RV echocardiographic examination with conventional and 3DE assessment using 3D auto RV software. Patients included 35/40 (87.5%) females with mean age of 15.6 ± 1.7 years. Using conventional pulmonary artery systolic pressure echocardiography-derived measurement, none of the c-SLE patients had pulmonary hypertension. By 3DE, RV end-systolic and end-diastolic volumes (p = < 0.001, 0.02, respectively) were greater, whereas 3D-derived RV ejection fraction (p < 0.001), septal, and lateral longitudinal strain (both p < 0.001) were lower in SLE. SDI displayed a significant correlation with 3D auto RV ejection fraction (EF), tricuspid annular plane systolic excursion (TAPSE), fractional area change, and RV longitudinal strain (RVLS)-free wall (p = 0.01, 0.003, 0.007, and < 0.001, respectively). Cumulative SLEDAI score also showed a significant correlation with RV EF, TAPSE, FAC, and RVLS-free wall (p = 0.03, 0.007, 0.002, and < 0.001, respectively). By multivariate regression analysis, SDI remained an independent predictor of RVLS-free wall (ß coefficient − 0.4, p = 0.03) and TAPSE (ß − 0.5, p = 0.02). Conclusion: Subtle right ventricular myocardial dysfunction could be detected in childhood-onset SLE patients, especially via 3D-derived auto RV echocardiographic parameters, despite the absence of evident pulmonary hypertension. These parameters correlate with the SLE disease activity and chronicity scores.

What is Known:

•Diseases of the cardiovascular system are one of the most common causes of morbidity and mortality in SLE patients.

•RV labeled the forgotten ventricle in many diseases, was also forgotten in SLE patients and has been rarely addressed in adults, with scarce research in pediatrics.

What is New:

•Right ventricular functions are affected in children with SLE in comparison to healthy controls, especially three-dimensional echocardiography-derived parameters, which is an aspect that has not been investigated in previous research in the pediatric age group.

•Some of the detected myocardial dysfunctions of the right ventricle correlated with SLE disease activity and chronicity-related scores.
Evidenzbasierte naturheilkundliche Pflegeinterventionen in der Schmerztherapie
Authors: Stolz Regina , Kaschdailewitsch Elke , Kröger Birgit , Noack Bettina , Mahler Cornelia 
Published: April 2023

ZusammenfassungBeruflich Pflegende sind in allen Versorgungssettings und bei allen Zielgruppen mit Patient:innen konfrontiert, die an akuten und/oder chronischen Schmerzen leiden. Obwohl in nationalen und internationalen Leitlinien zu chronischen Schmerzen die Bedeutung nichtmedikamentöser Maßnahmen (beispielsweise Wärme- und Kälteanwendungen) und edukativer Ansätze, wie der Vermittlung von Selbstmanagementstrategien im Umgang mit dem Schmerz, betont wird, ist die medikamentöse Therapie die am häufigsten angewendete Maßnahme bei chronischen Schmerzen. Ziel des vorliegenden Beitrags ist es, einen Einblick in das Potenzial naturheilkundlicher Pflegeinterventionen für die Versorgung von Schmerzpatient:innen zu geben, wobei der Fokus auf sogenannten Äußeren Anwendungen wie Wickeln und Auflagen liegt, die risikoarm und einfach anzuwenden sind, sodass sie zur Selbstanwendung geeignet sind. Die Anwendung nichtmedikamentöser Verfahren wie auch die Beratung und Schulung von Patient:innen in den Anwendungen bieten Pflegefachpersonen die Möglichkeit eines autonomen Handlungsfelds und machen den Pflegeberuf attraktiver, da ein eigenständiges und verantwortliches Handeln gefördert wird.
Synthesis of bio-based materials from agricultural residues for treatment of petrochemical wastewater
Authors: Nasir Mohammad , Kumar Praveen , Srivastava Vimal Chandra , Verma Shilpi , Kaur Ramanpreet , Mall Indra Deo , Štangar Urška Lavrenčič 
Published: April 2023

Abstract4-Carboxybenzaldehyde (4-CBA), a major component of purified terephthalic acid wastewater, is toxic to living organisms and required to be removed before the discharge of treated wastewater in a natural water body. In this work, the adsorptive removal of 4-CBA was studied using bagasse fly ash (BFA), a waste product from the sugar industry. The adsorption capacity of BFA was compared with the commercially available adsorbent, granular activated carbon (GAC). A 4-factorial, 5-stage central composite design (CCD) was used to optimize 4-CBA removal and adsorption uptake by BFA using response surface methodology (RSM). The variables considered for the study were pH, adsorbent dose (m), initial concentration (Co) and time (t). At the optimum treatment conditions of pH = 4,m = 9 g/L,Co = 100 mg/L andt = 7.5 h, the removal efficiency and adsorption uptake of 4-CBA on BFA were found to be 79% and 9.9 mg/g, respectively. BET surface area of BFA was determined to be 284 m2/g. A kinetic study was performed using a first- and second pseudo-order model. The adsorption equilibrium data were fitted for various adsorption models. A positive value$$\Delta H^{0}$$ΔH0indicates that the adsorption process is endothermic. This study indicated that BFA is a cost-effective adsorbent for the removal of 4-CBA with high adsorption capacity and fast kinetics.Graphical Abstract
Recent flex power changes
Authors: Esenbuğa Özge Gizem , Hauschild André , Steigenberger Peter 
Published: April 2023

AbstractThe redistribution of the transmit power among different GPS signal components is called flex power, and it is implemented on modernized GPS satellites starting with Block IIR-M. The purpose of the flex power is to increase signal protection against jamming. It has been mostly active since the beginning of 2017 in different flex power modes and is visible in the carrier-to-noise density ratio (C/N0) observations as stepwise changes. Especially after the beginning of 2020, the flex power modes changed frequently. We summarize these changes and study their impact on differential code biases (DCBs) which is 0.3 ns on average for L1 and L2 intra-frequency DCBs. The flex power is analyzed daily using C/N0 measurements of the globally distributed GNSS observations network from January 1, 2020 until February 28, 2022. The flex power activation times are written into a dedicated block of the SINEX metadata format.
Your place or mine? Exploring birdwatching tourists’ behaviour disturbing birds in a nature reserve
Authors: Aas Øystein , Jørgensen Frida Marie Omma , Stensland Stian , Reiertsen Tone , Dybsand Hilde Nikoline Hambro 
Published: April 2023

AbstractTo manage for more sustainable wildlife viewing tourism, a better understanding of tourists’ behaviour that might disturb and negatively affect wildlife such as birds is needed. We conducted a qualitative case study of visitors to Hornøya, a protected bird cliff in Northern Norway. Behaviours with the potential to disturb seabirds at the site were explored using the theory of planned behaviour as a guiding framework. In-depth interviews and observations were used to explore why some visitors perform illegal or unwanted, potentially harmful behaviours, and to understand attitudes, social norms, and perceived behaviour control as influencing factors. The tourists visited Hornøya to experience seabirds in their natural surroundings, without causing harm. They were emotionally affected by the bird encounters, which may lead to thoughts and reflections about environmental challenges and nature protection. Visitors generally did not intend to disturb birds during these encounters. However, many visitors interpreted the birds’ behaviour as meaning that they were not easily disturbed. Poorly developed social norms among visitors, in combination with limited presence of surveillance/guide personnel, and strong behavioural control among some visitors (willingness and ability to engage in illegal behaviour) led to occasional breaching of formal rules as well as incidents of inappropriate, potentially disturbing behaviour towards birds. Experienced wildlife photographers tended to show willingness and ability to engage in illegal behaviour more often than the two other segments.