bluuebunny/crossref_metadata_2025_split huggingface dataset:
Canagliflozin alleviates valproic acid-induced autism in rat pups: Role of PTEN/PDK/PPAR-γ signaling pathways
Authors: Elgamal Mariam A. , Khodeer Dina M. , Abdel-Wahab Basel A. , Ibrahim Ibrahim Abdel Aziz , Alzahrani Abdullah R. , Moustafa Yasser M. , Ali Azza A. , El-Sayed Norhan M. 
Published: February 2023

Autism is complex and multifactorial, and is one of the fastest growing neurodevelopmental disorders. Canagliflozin (Cana) is an antidiabetic drug that exhibits neuroprotective properties in various neurodegenerative syndromes. This study investigated the possible protective effect of Cana against the valproic acid (VPA)-induced model of autism. VPA was injected subcutaneously (SC) into rat pups at a dose of 300 mg/kg, twice daily on postnatal day-2 (PD-2) and PD-3, and once on PD-4 to induce an autism-like syndrome. Graded doses of Cana were administered (5 mg/kg, 7.5 mg/kg, and 10 mg/kg, P.O.) starting from the first day of VPA injections and continued for 21 days. At the end of the experiment, behavioral tests and histopathological alterations were assessed. In addition, the gene expression of peroxisome proliferator-activated receptor γ (PPAR γ), lactate dehydrogenase A (LDHA), pyruvate dehydrogenase kinase (PDK), cellular myeloctomatosis (c-Myc) with protein expression of glucose transporter-1 (GLUT-1), phosphatase and tensin homolog (PTEN), and level of acetylcholine (ACh) were determined. Treatment with Cana significantly counteracted histopathological changes in the cerebellum tissues of the brain induced by VPA. Cana (5 mg/kg, 7.5 mg/kg, and 10 mg/kg) improved sociability and social preference, enhanced stereotypic behaviors, and decreased hyperlocomotion activity, in addition to its significant effect on the canonical Wnt/β-catenin pathway via the downregulation of gene expression of LDHA (22%, 64%, and 73% in cerebellum tissues with 51%, 60%, and 75% in cerebrum tissues), PDK (27%, 50%, and 67% in cerebellum tissues with 34%, 66%, and 77% in cerebrum tissues), c-Myc (35%, 44%, and 72% in cerebellum tissues with 19%, 58%, and 79% in cerebrum tissues), protein expression of GLUT-1 (32%, 48%, and 49% in cerebellum tissues with 30%, 50%, and 54% in cerebrum tissues), and elevating gene expression of PPAR-γ (2, 3, and 4 folds in cerebellum tissues with 1.5, 3, and 9 folds in cerebrum tissues), protein expression of PTEN (2, 5, and 6 folds in cerebellum tissues with 6, 6, and 10 folds in cerebrum tissues), and increasing the ACh levels (4, 5, and 7 folds) in brain tissues. The current study confirmed the ameliorating effect of Cana against neurochemical and behavioral alterations in the VPA-induced model of autism in rats.
Insights into the pharmacodynamics and pharmacokinetics of meldonium after exposure to acute high altitude
Authors: Liu Fengying , Sui Xin , Wang Qian , Li Jinglai , Yang Weijie , Yang Yi , Xiao Zhenyu , Sun Yangyang , Guo Xiaoxuan , Yang Xinyi , Yang Jun , Wang Yongan , Luo Yuan 
Published: February 2023

Objective: Meldonium, a well-known cardioprotective drug, has been reported to be protective against pulmonary injury at high altitudes; however, the pharmacodynamics of meldonium in other vital organs under acute high-altitude injury are less investigated and the related pharmacokinetics have not been fully elucidated.Methods and Results: The present study examined the basic pharmacodynamics and pharmacokinetics (PK) in rat exposure to acute high-altitude hypoxia after intragastrical and intravenous pre-administration of meldonium. The results indicate that meldonium can improve acute hypoxia-induced pathological damage in brain and lung tissues, and restore blood biochemistry and routine blood index of heart, liver and kidney tissues under a simulated acute high-altitude environment. Furthermore, compared to the normoxia group, rats exposed to simulated high-altitude hypoxia and premedicated with intragastrical meldonium showed linear kinetics in the dose range of 25–100 mg/kg, with a significantly increase in the area under curve (AUC) and reduced clearance rate. No significant differences in these meldonium of PK parameters were observed with intravenous administration. Additionally, meldonium was involved in the regulation of succinic acid and 3-hydroxypropionic acid.Conclusion: These results will contribute to our understanding of the preclinical PK properties of meldonium and its acute high-altitude protective effects.
Spermatophore development in drones indicates the metabolite support for sperm storage in honey bees (Apis cerana)
Authors: Yan Lele , Song Huali , Tang Xiangyou , Peng Xiaomei , Li Yaohui , Yang Huan , Zhou Zeyang , Xu Jinshan 
Published: February 2023

Developing effective long-term sperm storage strategies to maintain activity requires an understanding of the underlying spermatophore developmental phase in drones. Here we compared the developmental processes and metabolites about seminal vesicles of drones from different parentages (0-24 d)in honeybee colonies, including mated queens, virgin queens, and worker bees. The results showed a similar developmental trend of seminal vesicles in thethree groups of drones on the whole, although there were significant differences in developmental levels, as well as in other indicators. Correlation analysis showed significant positive correlations between seminal vesicle width and sperm viability. The metabolomics of the seminal vesicles in drones from mated queens showed differences of the metabolites in each stage. Particularly, squalene identified among them was validated a protective effect on sperm vitality in vitro experiments. Together the results of these assays support that there were significant differences in the developmental levels of seminal vesicles among the three groups of drones in honeybees, wherein a significant correlation between sperm viability and the developmental levels of seminal vesicles were dissected. The metabolomics analysis and semen storage experiments in vitro display signatures of squalene that may act as an effective protective agent in maintaining sperm viability. Collectively, our findings indicate that spermatophore development in drones provides metabolite support, which contributes to research on the differences of sperm viability among drones in the future.
Psychiatric rehabilitation patterns in Italy: Results from the Italian Society of Psychosocial Rehabilitation (SIRP) survey
Authors: Viganò Caterina , Ariu Cassandra , Barbieri Deborah , Goffredi Alessia , Ferrara Luca , Rea Federico , Barlati Stefano , Vita Antonio ,   SIRP Survey Group
Published: February 2023

IntroductionPsychiatric rehabilitation can be considered a bidirectional technique, designed to allow patients to achieve their personal target, focusing on the individuals’ strengths and challenges related to these targets and also on the community organizations in which they will live them out. Unfortunately, psychiatric rehabilitation is too often not considered a first line treatment. Moreover, rehabilitation has been confused with a generic and rough practice, consisting of extemporary actions and aimless entertainments designed to fill “the time passing”.MethodsThe aim of this study was to increase the knowledge and awareness about the state of the art of different systems of management and funding of psychosocial rehabilitation in the Italian “real-world” rehabilitative settings, using a specifically developed questionnaire.ResultsThe data obtained are positive for some aspects of the rehabilitation interventions, in particular for the use of validated tools for the evaluation and revision of projects and for the trend to work on a team, even though the scarcity of evidence-based rehabilitation interventions applied in Italian psychiatric services is less encouraging.ConclusionThis survey presents, at least partially, the “real-world” of rehabilitation in Italy so that we can lay the foundations for the definition of an updated, validated and shared network of what is implemented in the context of psychiatric rehabilitation.
Impact of #PsychTwitter in promoting global psychiatry: A hashtag analysis study
Authors: Nawaz Faisal A. , Riaz Mehr Muhamad Adeel , Tsagkaris Christos , Faisal Umme H. , Klager Elisabeth , Kletecka-Pulker Maria , Kimberger Oliver , Willschke Harald , Khan Nagina , Sultan Meshal A. , Atanasov Atanas G. 
Published: February 2023

IntroductionMultiple studies have shown how valuable Twitter hashtags can be for promoting content related to different themes in the online community. This arena has grown into a rich data source for public health observation and understanding key trends in healthcare on a global scale. In the field of mental health in particular, it would be of benefit to understand and report the key stakeholders' (individual mental health professionals, academic organizations and their countries) trends and patterns of psychiatric knowledge and information dissemination using #PsychTwitter.ObjectiveIn this study, we aim to evaluate the achieved outreach of psychiatry-related tweets using the hashtag #PsychTwitter.MethodsWe utilized the Symplur Signals research analytics tool to characterize tweets containing #PsychTwitter from the 20th of August, 2019, to the 20th of August, 2022.ResultsThe #PsychTwitter movement resulted in 125,297 tweets that were shared by 40,058 Twitter users and generated a total of 492,565,230 impressions (views). The three largest identified groups of contributors were Doctors (13.8% of all tweets), Org. Advocacy (6.2% of all tweets), and Researcher/Academic (4% of all tweets) stakeholders. The top influential accounts consisted of 55 psychiatrists and 16 institutional or organizational accounts. The top 5 countries from where most of the tweets containing #PsychTwitter were shared include the United States (54.3% of all users), the United Kingdom (10.4% of all users), Canada (4.9% of all users), India (2% of all users), and Australia (1.8% of all users).ConclusionThis is the first of its kind study featuring the influence and usage of #PsychTwitter and covering its global impact in the field of psychiatry using the Twitter platform. Our results indicate that Twitter represents a broadly used platform for mental health-related discussions.
Maternal COVID-19 vaccine acceptance among Malaysian pregnant women: A multicenter cross-sectional study
Authors: Kalok Aida , Razak Dali Wira , Sharip Shalisah , Abdullah Bahiyah , Kamarudin Maherah , Dasrilsyah Rima Anggrena , Abdul Rahman Rahana , Kamisan Atan Ixora 
Published: February 2023

IntroductionThe coronavirus disease 2019 (COVID-19) caused a global pandemic that resulted in devastating health, economic and social disruption. Pregnant mothers are susceptible to COVID-19 complications due to physiological and immunity changes in pregnancy. We aimed to assess the maternal vaccine acceptance of the COVID-19 vaccine.MethodsA multi-center study across four teaching hospitals in the Klang Valley, Malaysia was conducted between September 2021 and May 2022. A survey was conducted using a self-administered electronic questionnaire. The survey instruments included; (1) maternal perception and attitude toward COVID-19 vaccination, (2) COVID-19 pregnancy-related anxiety, and 3) generalized anxiety disorder.ResultsThe response rate was 96.6%, with a final number for analysis of 1,272. The majority of our women were Malays (89.5%), with a mean age (standard deviation, SD) of 32.2 (4.6). The maternal vaccine acceptance in our study was 77.1%. Household income (p &lt; 0.001), employment status (p = 0.011), and health sector worker (p = 0.001) were independent predictors of maternal willingness to be vaccinated. COVID-19 infection to self or among social contact and greater COVID-19 pregnancy-related anxiety were associated with increased odds of accepting the SARS-CoV-2 vaccine. Women who rely on the internet and social media as a source of vaccine information were more likely to be receptive to vaccination (adjusted odd ratio, AOR 1.63; 95% CI 1.14–2.33). Strong correlations were observed between maternal vaccine acceptance and the positive perception of (1) vaccine information (p &lt; 0.001), (2) protective effects of vaccine (p &lt; 0.001), and (3) getting vaccinated as a societal responsibility (p &lt; 0.001).DiscussionThe high maternal vaccine acceptance rate among urban pregnant women in Malaysia is most likely related to their high socio-economic status. Responsible use of the internet and social media, alongside appropriate counseling by health professionals, is essential in reducing vaccine hesitancy among pregnant women.
Cyberbullying among college students in a Chinese population: Prevalence and associated clinical correlates
Authors: Jin Xingyue , Zhang Kun , Twayigira Mireille , Gao Xueping , Xu Huiming , Huang Chunxiang , Luo Xuerong , Shen Yanmei 
Published: February 2023

ObjectivesCyberbullying is quite common in adolescents and college students, and it influences mental health in many aspects. The purpose of this study was to investigate the prevalence of cyberbullying in Chinese college students and to look for related factors.MethodsEight thousand and ninety-eight college students aged 17–26 were enrolled in this cross-sectional study. We collected information of their sociodemographic data, depression (evaluated by Self-Rating Depression Scale), anxiety (evaluated by Self-Rating Anxiety Scale), lifetime suicidal behaviors (including suicidal ideation, suicidal plans, and suicide attempts), and experiences of cyberbullying for the past 12 months by online questionnaires.ResultsThe prevalence of cyberbullying for the past 12 months was 7.82% (633/8,098) among college students. Binary logistic regression analysis showed that sex (odds ratio, OR = 0.522, 95%CI = 0.433–0.629, p &lt; 0.001), suicide attempts (OR = 2.164, 95%CI = 1.589–2.948, p &lt; 0.001), depression (OR = 2.372, 95%CI = 1.602–3.512, p &lt; 0.001), and anxiety (OR = 1.911, 95%CI = 1.305–2.800, p = 0.001) were independently associated with cyberbullying.ConclusionCyberbullying is very common among college students in Hunan Province, China. Besides, being male, suicide attempts, depression and anxiety were independently associated with cyberbullying, which highlights the importance of paying attention to cyberbullying and addressing anxiety, depression, and suicidal behaviors among college students to better improve their mental health and prevent suicide.
Monitoring residues of pesticides in food in Brazil: A multiscale analysis of the main contaminants, dietary cancer risk estimative and mechanisms associated
Authors: Bitencourt de Morais Valentim Juliana Maria , Fagundes Tatiane Renata , Okamoto Ferreira Mariane , Lonardoni Micheletti Pâmela , Broto Oliveira Geise Ellen , Cremer Souza Milena , Geovana Leite Vacario Beatriz , Silva Janaína Carla da , Scandolara Thalita Basso , Gaboardi Shaiane Carla , Zanetti Pessoa Candiotto Luciano , Mara Serpeloni Juliana , Rodrigues Ferreira Seiva Fábio , Panis Carolina 
Published: February 2023

IntroductionPesticides pose a risk for cancer development and progression. People are continuously exposed to such substances by several routes, including daily intake of contaminated food and water, especially in countries that are highly pesticide consumers and have very permissive legislation about pesticide contamination as Brazil. This work investigated the relationship among pesticides, food contamination, and dietary cancer risk.MethodsAnalyzed two social reports from the Brazilian Government: the Program for Analysis of Residues of Pesticides in Food (PARA) and The National Program for Control of Waste and Contaminants (PNCRC).Results and discussionFirst, we characterized the main pesticide residues detected over the maximum limits allowed by legislation or those prohibited for use in food samples analyzed across the country. Based on this list, we estimated the dietary cancer risks for some of the selected pesticides. Finally, we searched for data about dietary cancer risks and carcinogenic mechanisms of each pesticide. We also provided a critical analysis concerning the pesticide scenario in Brazil, aiming to discuss the food contamination levels observed from a geographical, political, and public health perspective. Exposures to pesticides in Brazil violate a range of human rights when food and water for human consumption are contaminated.
Levels, sources, variations, and human health risk assessment of 90Sr and 137Cs in water and food around Sanmen Nuclear Power Plant (China) from 2011 to 2020
Authors: Wang Peng , Yu Shunfei , Zou Hua , Lou Xiaoming , Ren Hong , Zhou Lei , Lai Zhongjun , Xuan Zhiqiang , Gao Xiangjing , Xu Qiuliang , Zhou Zhen , Zhao Yaoxian , Cao Yiyao 
Published: February 2023

ObjectivesRadioactivity monitoring around nuclear facilities is crucial to provide important baseline data for effective detection of radioactive leakage to the environment. We aim to establish a baseline study for monitoring radioactive levels of 90Sr and 137Cs around Sammen Nuclear Power Plant (SNPP) and to assess their associated health impact on surrounding residents.MethodsIn this study, we collected water and food samples around the SNPP from 2011 to 2020 and determined for 90Sr and 137Cs activity concentrations. We statistically analyzed the temporal trends of 90Sr and 137Cs and evaluated their radiation exposure to the local residents.ResultsDuring this period, the activity concentrations of 90Sr and 137Cs varied within 1.2–9.9 mBq/L and 0.10–7.6 mBq/L in water, and 0.037–1.3 Bq/kg and 0.011–0.45 Bq/kg in food, respectively, with no significant seasonal variation trend.ConclusionsAll reported activity concentrations of 90Sr and 137Cs were significantly lower than the recommended value of WHO and Chinese national standards. There is no indication of notable radioactive release into the study area due to the operation of SNPP during 2018–2020. The annual effective doses (AEDs) from the ingestion of 90Sr and 137Cs in water and food were well below the international permissible limits, indicating the radiation exposure around SNPP during 2011–2020 was kept at a safe level.
Can black coral forests be detected using multibeam echosounder “multi-detect” data?
Authors: Feldens Peter , Held Philipp , Otero-Ferrer Francisco , Bramanti Lorenzo , Espino Fernando , Schneider von Deimling Jens 
Published: February 2023

The black coral Anthipatella wollastoni forms marine animal forests in the mesophotic zone. The spatial extent of black coral forests is not well known in many regions. Due to its protein and chitin skeleton, the coral is difficult to image using acoustic remote sensing techniques compared to corals with carbonate skeletons. Several manufacturers have recently introduced an additional data type to their multibeam echosounders, called “multi-detection,” which provides additional target detections per beam in addition to the primary bottom detection. In this study, we used a Norbit chirp multibeam echosounder in multi-detect mode to acquire up to three targets in each beam in an area of black coral below 45 m depth off the coast of Lanzarote (Canary Islands, Spain). Multi-detect allows features above and below the primary bottom detection to be identified without the need to store and process water-column data. Black coral can be detected by comparing “multi-detection” data with ground truthing by technical divers and underwater cameras. However, the repeatability of the detections is limited and further sensitivity studies are required.
Vacuum-stent: A combination of endoscopic vacuum therapy and an intraluminal stent for treatment of esophageal transmural defects
Authors: Pattynama Lisanne M. D. , Eshuis Wietse J. , van Berge Henegouwen Mark I. , Bergman Jacques J. G. H. M. , Pouw Roos E. 
Published: February 2023

IntroductionEndoscopic vacuum therapy (EVT) has gained a greater role in management of transmural defects in the upper gastrointestinal (GI) tract, including anastomotic leakage and esophageal perforation (e.g. Boerhaave syndrome and iatrogenic causes). The vacuum-stent is a new treatment modality, combining the benefits of EVT and an intraluminal stent.Patients and methodsThis prospective case series describes the first ten cases of a transmural defect in the upper GI tract treated with a vacuum-stent in a tertiary referral center. All patients signed informed consent for prospective registration of relevant data on treatment and outcomes in a specially designed database. Outcome parameters were successful closure of the defect, number of endoscopies, duration of treatment and adverse events.ResultsIn total, ten patients treated with a vacuum-stent were included. Eight patients had anastomotic leakage after esophageal resection, of whom six were treated with vacuum-sponge and vacuum-stent, and two with vacuum-stent only. One patient had Boerhaave syndrome, treated with vacuum-sponge and vacuum-stent, and one had an iatrogenic perforation during pneumodilation for achalasia, treated with vacuum-stent only. Success rate was 100%, requiring a median of 5 (IQR 3–12) EVT-related endoscopies with a treatment course of median 18 (IQR 12–59) days. One patient developed an esophageal stricture, but no other vacuum-stent related adverse events were observed.ConclusionThe vacuum-stent, which combines benefits of EVT and an intraluminal stent, shows great feasibility and efficacy in treatment of transmural defects in the upper GI tract. Future studies should point out whether this device can prevent major (re-)surgery in these patients.
Diversité technique des débitages laminaires au Néolithique ancien à Vaux-et-Borset (Hesbaye, Belgique) : manières de faire, problèmes d’interprétation et perspectives anthropologiques
Authors: Denis Solène , Burnez-Lanotte Laurence 
Published: February 2023

Cette étude explore la diversité technique de la production laminaire dans les villages rubané et Blicquy/
Villeneuve-Saint-Germain de Vaux-et-Borset (Hesbaye, Belgique). Cette diversité technique est essentiellement définie
par un traitement différentiel des plans de frappe et des préparations au détachement des lames. Or, les différences relevées
ne conduisent pas à la production de supports pour un outillage spécifique. Elles ne se justifient pas non plus par
les qualités intrinsèques des matières premières. À contexte de production équivalent, nous proposons dès lors que cette
variabilité technique reflète différentes manières de faire parmi les tailleurs du village de Vaux-et-Borset. La reconnaissance
d’une véritable continuité de certaines manières de faire entre le Rubané et la culture Blicquy/ Villeneuve-Saint-
Germain atteste de leur transmission dans le temps. Cette transmission signe la coexistence d’au moins deux filières
d’apprentissage chez les tailleurs au Néolithique ancien. Par ailleurs, les tailleurs rubanés du village de Vaux-et-Borset semblent presque tous issus du même réseau d’apprentissage contrairement aux quatre groupes distingués chez les tailleurs blicquiens. La diversité des pratiques techniques et des traditions techniques au cours du Blicquien est discutée.
En l’état actuel des données, il semble qu’elle puisse à la fois résulter de la mobilité de populations avoisinantes et du
syncrétisme de certaines traditions.