bluuebunny/crossref_metadata_2025_split huggingface dataset:
Microfluidic Approach for Enhanced Paeoniflorin Transdermal Delivery: A Comparative Study on Different Chips and Mixing Dynamics
Authors: Gu Qifei , Xiao Wuqing , Zhu Yingyin , Zhong Wanling , Sui Xue , Liu Yongchao , Zhang Jie , Wu Huichao , Zhou Rui 
Published: January 2025

Abstract
Paeoniflorin is a natural pharmaceutical ingredient with a widely biological activity. However, as a hydrophilic drug, the problem of low transdermal rate limits its clinical application. To overcome this shortage, LUVs were used as biocompatible carriers of paeoniflorin in this study. We prepared paeoniflorin-loaded large unilamellar vesicles (LUVs) with W/O/W structure by microfluidics. We used four kinds of chips to prepare paeoniflorin LUVs and explored the effects of the chip structures on LUVs properties applying both experiments and numerical simulations. The difference of fluid mixing mechanisms was analyzed among four different channels, including straight and curved structures. Then we evaluated the differences in skin permeability among the three groups, paeoniflorin aqueous solution group, drug-loaded liposome group and blank liposome & drug mixture group, using the abdominal skin of male mice. The results showed that the structure of the microfluidic channel was a key factor affecting the flow rate and mixing efficiency. The mixing efficiency further affected the liposome size. The mixing efficiency of curved channel was not better than that of a straight channel due to the low flow rate and long mixing time. By the results of transdermal experiments, LUVs could reduce the transdermal time and increase the total transdermal amount. LUVs effectively improved the transdermal absorption efficiency of paeoniflorin. In conclusion, paeoniflorin LUVs with highly efficient transdermal were successfully prepared by using microfluidics. We explored the underlying fluid dynamics that lead to variations in the preparation with different chip structures. The transdermal effect of the LUVs was verified.

Graphical Abstract
Model Averaging Under Flexible Loss Functions
Authors: Gu Dieqi , Liu Qingfeng , Zhang Xinyu 
Published: January 2025

To address model uncertainty under flexible loss functions in prediction problems, we propose a model averaging method that accommodates various loss functions, including asymmetric linear and quadratic loss functions as well as many other asymmetric/symmetric loss functions as special cases. The flexible loss function allows the proposed method to average a large range of models such as the quantile and expectile regression models. To determine the weights of the candidate models, we establish a J-fold cross-validation criterion. Asymptotic optimality and weight convergence are proved for the proposed method. Simulations and an empirical application show the superior performance of the proposed method compared with other methods of model selection and averaging. History: Accepted by Ram Ramesh, Area Editor for Data Science and Machine Learning. Funding: This work was supported by the Beijing Natural Science Foundation [Grant Z240004], Japan Society for the Promotion of Science (KAKENHI) [Grant 22H00833 to Q. Liu], the CAS Project for Young Scientists in Basic Research [Grant YSBR-008], and the National Natural Science Foundation of China [Grants 71925007, 72091212 and 72495124]. Supplemental Material: The software that supports the findings of this study is available within the paper and its Supplemental Information ( https://pubsonline.informs.org/doi/suppl/10.1287/ijoc.2023.0291 ) as well as from the IJOC GitHub software repository ( https://github.com/INFORMSJoC/2023.0291 ). The complete IJOC Software and Data Repository is available at https://informsjoc.github.io/ .
Accuracy of pulse wave velocity for screening coronary artery disease: a systematic review and meta-analysis
Authors: Lever-Megina Carla-Geovanna , Cavero-Redondo Iván , Álvarez-Bueno Celia , Morales-Berenkova Cristina , Cabeza-Arrebola Germán , Saz-Lara Alicia 
Published: January 2025

Abstract
Coronary artery disease (CAD) is the leading cause of cardiovascular events and showed high prevalence and healthcare costs in 2019. However, CAD screening for cardiovascular event prevention is invasive and expensive. This study aims to estimate the ability of a noninvasive method, pulse wave velocity (PWV), to detect the presence or absence of coronary artery disease in patients with suspected CAD. A systematic review and meta-analysis of the available evidence was conducted, comparing PWV with the gold standard diagnostic method, angiography. The literature search was systematically performed in the PubMed, Scopus and Web of Science databases from inception to August 2024. Study quality assessment was performed using the Diagnostic Accuracy Study Quality Assessment Tool (QUADAS-2). Publication bias was assessed using the method proposed by Deeks. Statistical analyses were performed with the STATA SE software, version 15. The eight included studies had a cross-sectional design, in which the presence of CAD was measured simultaneously by PWV and angiography. To assess the accuracy of the tests, the overall sensitivity and specificity were combined into a single value, the diagnostic odds ratio (dOR), which provided a value of 3.61, indicating a high probability of detecting CAD by PWV. The implementation of PWV as a screening technique in healthcare centers could bring great benefits to patients with suspected CAD and increase efficiency in the use of healthcare resources.
Cardinal predation of the invasive Jorō spider Trichophila clavata (Araneae: Nephilidae) in Georgia
Authors: Pemberton Robert W. 
Published: January 2025

Abstract
The invasive Jorō spider (Trichophila clavata L. Koch: Araneae: Nephilidae), which was found to be established in Georgia in 2014, has become abundant and spread to many other states. Almost nothing is known about what predates the Jorō spider in its invasive range. A previous paper reported a Northern Cardinal (Cardinalis cardinalis L. [Passeriformes: Cardinalidae]) perching on the web of a Jorō spider and lunging towards it, in what was interpreted to be a predation attempt. This note reports attacks by two Northern Cardinals (referred to hereafter as Cardinal) on Jorō spiders in Atlanta, Georgia. The first attack was observed when a male Cardinal continuously pecked at the top of a caged Jorō, just above the large female spider. Shortly after this attack a large living female Jorō spider was tethered by a thread around the pedicel and hung above and near to the caged Jorō that was attacked. After nearly an hour had passed, a female Cardinal flew in and grabbed the Jorō in its beak and tried to fly away with the spider. The Cardinal quickly returned and attacked the spider two more times but was unable to fly away with it because the tether held the spider in place. The spider was killed but not dismembered. Cardinals may be responsible for the destroyed and empty Jorō webs that are commonly seen. Although Cardinals are thought by many people as seed feeders, research has shown that they are among the most insectivorous of common birds.
Antiangiogenic potential of Elaeagnus umbellata extracts and molecular docking study by targeting VEGFR-2 pathway
Authors: Nazir Nausheen , Waqar Arbaz , Zaib Khan Amir , Ali Khan Ayaz , Aziz Tariq , Alasmari Abdullah F. 
Published: January 2025

Abstract

Background
Anti-angiogenesis or inhibition of blood vessel formation is the best way to prevent the growth and metastasis of tumors. Natural sources like plants are currently being explored for its antiangiogenic activity as they are factories of various phytochemicals. The goal of the current study is to investigate the antiangiogenic potential of Elaeagnus umbellata (E. umbellata) by using chorioallantoic membrane (CAM) assay and molecular docking.

Methods
Based on our previous research, the antiangiogenic activity was carried out using active fractions including crude methanol (Eu-Met), ethyl acetate (Eu-EtAc), and chloroform (Eu-Chf) extracts using CAM assay. Furthermore, to understand the binding mechanism of identified compounds, molecular docking was performed against vascular endothelial growth factor receptor 2 (VEGFR-2) using AutoDock vina as docking software. VEGFR-2 is overexpressed in pathological angiogenesis.

Results
In CAM assay, Eu-Met, Eu-EtAc, and Eu-Chf extracts showed antiangiogenic activities but notable antiangiogenic activities were exhibited by Eu-Chf with IC50 value of 65.02 μg/mL. In molecular docking, five compounds, catechin, catechin hydrate, morin, quercetin, and rutin, reported in the extract and active fractions (Eu-Met, Eu-EtAc, and Eu-Chf) of E. umbellata showed strong interactions with VEGFR-2 with binding affinities of −9.4, −9.3, −9.9, −10.2, and −9.4 kcal/mol.

Conclusion
Based on our results, we can claim that E. umbellata possess antiangiogenic activity which needs to be explored further.
Exploring metapragmatics of politeness lexemes using a computational approach
Authors: Chen Xi , Shin Gyu-Ho , Lee Jungmin 
Published: January 2025

Abstract
This study employs a computational method, together with qualitative analysis, to explore the metapragmatics of politeness lexemes that both scholars and laypersons fail to provide effective articulations for. We specifically choose two bewildering politeness lexemes – kyemson (‘modesty’) and kongson (‘politeness’) – in Korean, and use the computational approach to identify their metapragmatic differences by analyzing over 27,000 texts that feature their usage. Results show that, while kyemson is associated with speakers’ personal and interpersonal qualities, kongson is manifested in a range of normative semiotic practices. They both feature the concepts of lowering oneself and elevating others, but realize them at different levels. In addition, kyemson helps to achieve relational harmony regardless of social hierarchies, and kongson reinforces social hierarchies but speaks little of relational harmony. The findings make two important contributions – namely, providing a novel methodology to address the pitfall in analysing first-order and second-order politeness, and offering an insight into the underexplored politeness lexemes in Korean.
Health Care Facility Characteristics Associated With Providing Telehealth HIV Care Services During the COVID-19 Pandemic
Authors: Valverde Eduardo E. , Beer Linda , Pepin Dawn , Crim Stacy , Weiser John 
Published: January 2025

Objectives. To describe provision of HIV telehealth services during the COVID-19 pandemic using data from the Centers for Disease Control and Prevention (CDC) Medical Monitoring Project Facility Survey for the Ending the HIV Epidemic in the United States initiative, which aims to achieve an at least 90% reduction in new HIV infections by 2030 and highlights telehealth as an important strategy. Methods. During 2021, we surveyed 1023 facilities providing HIV care to a nationally representative sample of US adults with diagnosed HIV, of which 45% responded. We calculated weighted percentages with 95% confidence intervals comparing the characteristics of facilities providing telehealth services. Results. Overall, 83.4% of facilities provided HIV care telehealth services by the facility’s own providers (82.0%) or by outside providers through remote conferencing (27.0%). Gaps in coverage were identified in smaller facilities and in facilities in rural and primary care health professional shortage areas. Conclusions. Although most HIV care facilities provided telehealth services during the COVID-19 pandemic, gaps were identified, which must be addressed to meet Ending the HIV Epidemic in the United States goals and better prepare for future health emergencies. ( Am J Public Health. 2025;115(3):349–353. https://doi.org/10.2105/AJPH.2024.307908 )
Real-time Emotion Regulation in Virtual Reality: An Adaptive Experience using Breathing Biofeedback
Authors: Lima Rodrigo , Chirico Alice , Gaggioli Andrea , Gamboa Hugo , Badia Sergi Bermúdez i 
Published: January 2025

Abstract

Virtual reality has increasingly been integrated with biofeedback systems for treating affective states such as depression and anxiety. The implementation of stress exposure therapies that adapt in real-time to individuals' physiological signals improves patients' ability to deal with real life stressors. This work evaluates the effect of a real-time adaptive closed-loop system using breathing rate as a biofeedback visual cue in an immersive, nature-based restorative virtual environment. Participants were divided into two groups and exposed to a baseline condition and different stressors: two Stroop Color-Word tests and a restorative virtual reality exploration task in the Virtual Levada. Their physiological signals (electrocardiography, electrodermal activity, and respiration) were recorded and subjective stress levels were annotated . The adaptive group received biofeedback based on their breathing rate, using the field of view as a representation of their stress levels, which was adapted using rule-based changes. Results revealed significant differences in physiological responses across experimental conditions. Specifically, the adaptive biofeedback group reported lower levels of stress during the immersive virtual reality task compared to the Stroop tests, highlighting the restorative effect of the Virtual Levada. These findings suggest that real-time adaptive biofeedback systems, when integrated with restorative elements, enhances users' ability to regulate their stress responses.
Effective and Sustainable Surface Microbial Control using Electric field treatment for Global Hygiene and Industrial Anti-biofouling
Authors: Xie Xing , Liu Feifei , Gajula Durga 
Published: January 2025

Abstract

Surface microbial contamination presents enormous challenges to global hygiene and brings industries financial burdens. In this study, a novel electrophysical microbial control surface on the basis of electric field treatment with microscale interdigitated electrodes (MIDEs) is introduced. It is demonstrated that the MIDE surface exhibits superb bactericidal efficiency when applying low-voltage (sub-36 V) unipolar pulses. Exposed to bacterial cultures, the MIDEs also effectively inhibit biofilm forming after bacterial inoculation. Electroporation is indicated as the predominant microbicidal mechanism. This work is critical for understanding the efficacy of electric field treatment for pathogen inactivation and introduces a more sustainable strategy for surface microbial control.
<u>Assessment of Glucosuria and Ketonuria in Diabetic Patients Attending Gitwe District Hospital</u>
Authors: Alain Prudence ISHIMWE , Tharcisse GATEMBEZI , Donatien MUTABAZI , Jean Paul NSHUTI , Bernard ITANGISHATSE , Phillipe HAKIZIMANA , Lauben NSABIYAREMYE 
Published: January 2025

Background: Glucosuria and ketonuria are serious condition which mostly occur and affect in diabetes mellitus. Glycosuria is a rare condition in which kidney excrete glucose into the urine, nearly always caused by elevated blood glucose levels, most commonly due to untreated diabetes mellitus. while Ketonuria is a medical condition in which ketone bodies are present in the urine. It is seen in conditions in which the body produces excess ketones as an alternative source of energy. It is seen during starvation or more commonly in type I diabetes mellitus.
Aim: This cross-sectional study was conducted with the aim of assessing the levels of glucosuria and ketonuria in diabetes patients attending Gitwe District Hospital.
Methodology: The glucosuria and ketonuria in diabetes patients were tested. The study populations mainly comprised of diabetes patients, 116 study participants were included, the majority were 64.7% female while 35.3% were male. Urine sample was collected from diabetes patients and samples analysis was performed in biochemistry service of Gitwe District Hospital for glucosuria and ketonuria analysis using urine chemistry strips.
Results: During data analysis, the highest frequency of participants present in this study were (34.6%) between 51-60 years old. The mean age was 51years ± 10.787 SD (ranged from 26 – 79 years). 21.5% patients experienced glucosuria and 11.1% lived with ketonuria. correlation between glucosuria and ketonuria was found to be highly positive and statistically significant of 0.001 with Correlation Coefficient (r) of 0.886, which indicates that when glucosuria increase leads to increase of ketonuria too.
Conclusion: There are very few studies on glucosuria and ketonuria in diabetes patients, researchers are recommended to conduct researches related to this. Further researches are recommended to study the effects of change of glucosuria and ketonuria especially their association in diabetes patients.
Keywords: Glucosuria, Ketonuria, Diabetes, Insulin
Composition and Drug Release Characteristics of Bi-layered and Multi-layered Tablets: A Comprehensive Review
Authors: Ferdousi Fatiha Momtaz , Safrin Farhani , Ali Md. Nawshed , Juhan Abdullah Al , Akter Priyanka 
Published: January 2025

Multilayer and Bilayer tablets are winning popularity over single-layer tablets because of their controlled release advantages. Since each layer of API must be compatible with the others and with excipients to extend the effects of the medication or drugs and improve patient compliance, technology for creating multilayers and bilayers is less widespread than that for single-layer tablets. Hydrophilic polymers are more frequently employed in the formulation of biliary and multilayer tablets as both medication carriers and release barriers. But the ratio of using polymer is different from each other in the drug barrier layer and carrier layer that can make alteration by a researcher to develop a difference in the release rate of different APIs in a single unit of the tablet. With a larger surface area and a faster rate of drug release over time, multilayer and biliary tablets can help mitigate the non-linearity and drug interactions that arise with diffusion-controlled matrix devices. This review article covers the different techniques used to create biliary and multilayered tablets as well as the challenges associated with their formulation.
Keywords: Multi-layer tablets, Bi-layer tablets, Drug release, Tablet manufacturing
Prediction of household food insecurity in rural China: an application of machine learning methods
Authors: Zhao Longqiang , Yang Minda , Min Shi , Qing Ping 
Published: January 2025

Abstract
Ensuring the accurate prediction of food insecurity among rural households is an essential prerequisite for the implementation of effective interventions aimed at mitigating the risk of household food insecurity. While machine learning has demonstrated potential in enhancing prediction the accuracy of predictions related to household food insecurity, its application remains relatively limited in predicting household food insecurity in rural China. Based on a dataset comprising 3-day food consumption records from 1080 rural households in China, calorie intake was selected as a key indicator for measuring household food insecurity. This study employed machine learning algorithms, specifically the random forest (RF) and least absolute shrinkage and selection operator regression (LASSO), alongside traditional econometric methods, to predict household food insecurity. Additionally, it compared the predictive performance of these machine learning algorithms against that of traditional econometric approaches. The result indicates that RF methods exhibited the highest performance in prediction accuracy, achieving an accuracy of up to 65.7%, closely followed by the LASSO methods. Moreover, this study identified household income, food market accessibility and availability as the most feature variables for predicting household food insecurity. Overall, this study not only demonstrates the viability of machine learning techniques in predicting household food insecurity but also offers valuable implications for preventing the occurrence of household food insecurity in rural China and other developing regions.
Travel to historical sites as a factor in the development of territorial entrepreneurship and culture of society
Authors: Shpilkina T. A. 
Published: January 2025

This study is devoted to the development of domestic tourism to historical sites, brief descriptions of the most interesting historical sites (estates) are given Moscow and St. Petersburg, as well as the regions of the country. Analytical data on tourist flows in the two capitals for the first nine months of 2023–2024 are presented. The role of tourism development for the segment of small and medium–sized enterprises is outlined.The results of the study are drawn to the disproportionality of the applied preferential programs in different regions of the Russian Federation. The author notes that it is necessary to develop preferential programs based on the incomes and opportunities of the subjects of the Russian Federation, so that no region is left without attention from the Government of the Russian Federation, and the development of tours to historical sites will not only form spiritual values among young people, promote education and enlightenment of families with children, but also It will increase the number of SMEs in all regions of the country and increase their contribution to the territorial and federal budgets.
Income and expenses from the rental of specialized equipment
Authors: Ovchinnikova E. M. 
Published: January 2025

The subject of the article is the specifics of recognizing income and expenses from leasing specialized equipment under an operating lease agreement from a lessor. The research methods are analysis, synthesis, and deduction. The results of the study can be used in the organization of accounting for specialized equipment from the landlord.The content of the lease agreement affects the formation of information on the income and expenses of the organization. A legal basis has been outlined that determines the conclusion of a lease agreement for specialized equipment and the reflection of information about it in accounting (financial) statements. The main problems of the lease agreement for specialized equipment have been identified. The article justifies the need to determine the legal status of specialized equipment. This is due to its unreasonable identification with ground vehicles in regulatory documents. Methods for determining the amount of rent are highlighted. The problems of determining the rent as the basis for the amount of revenue in the case of dependence of the rent on the time of actual use of the property by the tenant are indicated. The author justified the problems of tracking the time of actual use of the object. The article draws a relationship between the model of the lease agreement and the entity bearing the main costs of maintaining the facility. The transfer of the object for rent with a crew increases the costs of the landlord.