bluuebunny/crossref_metadata_2025_split huggingface dataset:
Real world practice of postoperative radiotherapy for patients with completely resected pIIIA-N2 non-small cell lung cancer: a national survey of radiation oncologists in China
Authors: Zhou Shujie , Zhai Yirui , Zhao Kaikai , Men Yu , Meng Xiangjiao , Hui Zhouguang 
Published: January 2023

Abstract
Background
Results from Lung ART and PORT-C trials suggest that postoperative radiotherapy (PORT) cannot routinely be recommended as standard treatment in completely resected pIIIA-N2 NSCLC patients, but their effects on the real-world practice of PORT in China remain unclear.

Methods
A national cross-section survey was conducted by using an online survey service. Participants were voluntarily recruited using a river sampling strategy. A link to the survey was posted on websites of radiation oncologist associations and tweets from public WeChat accounts. The survey collected the real names of participants to ensure that they were board-certified radiation oncologists.

Results
A total of 484 radiation oncologists were included with a median age of 40 years (IQR, 35–47). A total of 377 (77.9%) participants were male, and 282 (58.1%) had more than 10 years of clinical experience practicing thoracic radiotherapy. Before Lung ART and PORT-C trials were published, 313 (64.7%) respondents recommended PORT, 11 (2.3%) did not recommend it, and 160 (33.1%) reported that they made decisions based on risk factors. After the presentation of two trials, only 42 (8.7%) did not recommend PORT, while 108 (22.3%) recommended it, and 334 (69.0%) made decisions based on risk factors. The five most commonly considered risk factors among these 334 respondents were as follows: nodal extracapsular extension, the highest lymph node (LN) station involved, the number of dissected mediastinal LN stations, the number of positive mediastinal LN stations, and surgical approaches. In addition, the majority of all 484 respondents recommended a total dose of 50 Gy, lung stump + ipsilateral hilus + regions containing positive LNs as the targeted region, lung V20 < 25%, and heart V30 < 40% as dose constraints for PORT.

Conclusion
Most Chinese radiation oncologists recommended PORT for completely resected IIIA-N2 NSCLC patients based on risk factors, especially status of LN station.
COS-Speech: protocol to develop a core outcome set for dysarthria after stroke for use in clinical practice and research
Authors: Mitchell C. , Bowen A. , Conroy P. , Whelan B. M. , Wallace S. J. , Dancer A. , Woodward-Nutt K. , Kirkham J. J. 
Published: January 2023

Abstract
Background
Dysarthria after stroke is when speech intelligibility is impaired, and this occurs in half of all stroke survivors. Dysarthria often leads to social isolation, poor psychological well-being and can prevent return to work and social lives. Currently, a variety of outcome measures are used in clinical research and practice when monitoring recovery for people who have dysarthria. When research studies use different measures, it is impossible to compare results from trials and delays our understanding of effective clinical treatments. The aim of this study is to develop a core outcome set (COS) to agree what aspects of speech recovery should be measured for dysarthria after stroke (COS-Speech) in research and clinical practice.

Methods
The COS-Speech study will include five steps: (1) development of a long list of possible outcome domains of speech that should be measured to guide the survey; (2) recruitment to the COS-Speech study of three key stakeholder groups in the UK and Australia: stroke survivors, communication researchers and speech and language therapists/pathologists; (3) two rounds of the Delphi survey process; (4) a consensus meeting to agree the speech outcomes to be measured and a follow-up consensus meeting to match existing instruments/measures (from parallel systematic review) to the agreed COS-Speech; (5) dissemination of COS-Speech.

Discussion
There is currently no COS for dysarthria after stroke for research trials or clinical practice. The findings from this research study will be a minimum COS, for use in all dysarthria research studies and clinical practice looking at post-stroke recovery of speech. These findings will be widely disseminated using professional and patient networks, research and clinical forums as well as using a variety of academic papers, videos, accessible writing such as blogs and links on social media.

Trial registration
COS-Speech is registered with the Core Outcome Measures in Effectiveness Trials (COMET) database, October 2021 https://www.comet-initiative.org/Studies/Details/1959.
In addition, “A systematic review of the psychometric properties and clinical utility of instruments measuring dysarthria after stroke” will inform the consensus meeting to match measures to COS-Speech. The protocol for the systematic reviews registered with the International Prospective Register of Systematic Reviews. PROSPERO registration number: CRD42022302998.
miR-132-3p and KLF7 as novel regulators of aortic stiffening-associated EndMT in type 2 diabetes mellitus
Authors: Hulshoff Melanie S. , Schellinger Isabel N. , Xu Xingbo , Fledderus Jolien , Rath Sandip K. , Wong Fang Cheng , Maamari Sabine , Haunschild Josephina , Krenning Guido , Raaz Uwe , Zeisberg Elisabeth M. 
Published: January 2023

AbstractBackgroundThe prevalence of diabetes mellitus has risen considerably and currently affects more than 422 million people worldwide. Cardiovascular diseases including myocardial infarction and heart failure represent the major cause of death in type 2 diabetes (T2D). Diabetes patients exhibit accelerated aortic stiffening which is an independent predictor of cardiovascular disease and mortality. We recently showed that aortic stiffness precedes hypertension in a mouse model of diabetes (db/db mice), making aortic stiffness an early contributor to cardiovascular disease development. Elucidating how aortic stiffening develops is a pressing need in order to halt the pathophysiological process at an early time point.MethodsTo assess EndMT occurrence, we performed co-immunofluorescence staining of an endothelial marker (CD31) with mesenchymal markers (α-SMA/S100A4) in aortic sections from db/db mice. Moreover, we performed qRT-PCR to analyze mRNA expression of EndMT transcription factors in aortic sections of db/db mice and diabetic patients. To identify the underlying mechanism by which EndMT contributes to aortic stiffening, we used aortas from db/db mice and diabetic patients in combination with high glucose-treated human umbilical vein endothelial cells (HUVECs) as an in vitro model of diabetes-associated EndMT.ResultsWe demonstrate robust CD31/α-SMA and CD31/S100A4 co-localization in aortic sections of db/db mice which was almost absent in control mice. Moreover, we demonstrate a significant upregulation of EndMT transcription factors in aortic sections of db/db mice and diabetic patients. As underlying regulator, we identified miR-132-3p as the most significantly downregulated miR in the micronome of db/db mice and high glucose-treated HUVECs. Indeed, miR-132-3p was also significantly downregulated in aortic tissue from diabetic patients. We identified Kruppel-like factor 7 (KLF7) as a target of miR-132-3p and show a significant upregulation of KLF7 in aortic sections of db/db mice and diabetic patients as well as in high glucose-treated HUVECs. We further demonstrate that miR-132-3p overexpression and KLF7 downregulation ameliorates EndMT in high glucose-treated HUVECs.ConclusionsWe demonstrate for the first time that EndMT contributes to aortic stiffening in T2D. We identified miR-132-3p and KLF7 as novel EndMT regulators in this context. Altogether, this gives us new insights in the development of aortic stiffening in T2D.
Levothyroxine absorption test followed by directly observed treatment on an outpatient basis to address long-term high thyrotropin levels in a hypothyroid patient: a case report
Authors: Kiran Zareen , Shaikh Khalilullah Shabbir , Fatima Nazish , Tariq Namra , Baloch Akhtar Ali 
Published: January 2023

Abstract
Background
For the treatment of hypothyroidism, patients are usually placed on lifelong levothyroxine replacement therapy. Achieving clinical and biochemical euthyroid status is sometimes difficult because of several factors, including poor compliance or poor absorption of levothyroxine in the gut mucosa.

Case presentation
We present the case of a 45-year-old South Asian female with hypothyroidism on lifelong levothyroxine replacement. However, on her multiple follow-up visits over the past 2 years, it was noted that her thyrotropin level was never controlled and was not in range. A thorough history was unyielding in terms of compliance regarding levothyroxine medication and use of over-the-counter pills or mineral supplements that may interfere with the absorption of levothyroxine. Hence, we performed levothyroxine absorption test to rule out any malabsorption as well as document pseudo-malabsorption favoring drug nonadherence. Levothyroxine absorption test resulted in more than 56% absorption of levothyroxine; therefore, the patient was put on weekly directly observed treatment strategy resulting in normalization of thyrotropin levels on successive follow-ups.

Conclusion
Directly observed treatment to replace levothyroxine once a week can be used as an alternative by health care professionals in patients in whom compliance to daily levothyroxine is the hidden cause of persistently raised thyrotropin. This strategy can reduce undue health burden on the patient and improve adherence to self-medication under confident supervision of the treating physician.
Inequality of opportunity in health service utilization among middle-aged and elderly community-dwelling adults in China
Authors: Zhu Lin , Peng Mingyao , Jiang Luyan , Wang Zhonghua 
Published: January 2023

Abstract
Background
The inequality caused by circumstances is known as "inequality of opportunity" (IOp). Many scholars have studied IOp in the health field, but few studies have quantified contributors to the IOp of health service utilization among middle-aged and elderly people. This study measured the IOp of health service utilization and decomposed the contributors to IOp present among Chinese middle-aged and elderly people.

Methods
Data were obtained from the China Health and Retirement Longitudinal Study (CHARLS) in 2013, 2015 and 2018. A mean-based regression method was adopted to measure the IOp of health service utilization. Shapley–Shorrocks decomposition was used to analyze the main contributors to IOp seen among the middle-aged and elderly.

Results
Although the absolute IOp of health service utilization decreased over time, IOp still explains the total inequality to a large extent. The absolute IOp and relative IOp were greatest in the areas of self-treatment and inpatient care utilization, respectively. Shapley decomposition results showed that the out-of-pocket (OOP) ratio contributed most to the IOp of outpatient care utilization; and the residence area highly explains the IOp of inpatient service utilization. Meanwhile, social and economic factors such as work status and income contribute more to the IOp of inpatient care utilization than outpatient and self-treatment.

Conclusions
Strategies aimed at achieving equal opportunities remain necessary to ensure the fairness of health service utilization. Policies and measures should further adjust the medical insurance compensation policies, and pay more attention to the middle-aged and elderly residents in rural areas, optimize health resource allocation, improve the social security systems, and narrow the socioeconomic gap between urban and rural areas in China.
Growth, yield and fiber quality characteristics of Bt and non-Bt cotton cultivars in response to boron nutrition
Authors: MEHRAN Muhammad , ASHRAF Muhammad , SHAHZAD Sher Muhammad , SHAKIR Muhammad Siddique , AZHAR Muhammad Tehseen , AHMAD Fiaz , ALVI Alamgir 
Published: January 2023

AbstractBackgroundBoron (B) deficiency is an important factor for poor seed cotton yield and fiber quality. However, it is often missing in the plant nutrition program, particularly in developing countries. The current study investigated B's effect on growth, yield, and fiber quality of Bt (CIM-663) and non-Bt (Cyto-124) cotton cultivars. The experimental plan consisted of twelve treatments: Control (CK); B at 1 mg·kg−1soil application (SB1); 2 mg·kg−1B (SB2); 3 mg·kg−1B (SB3); 0.2% B foliar spray (FB1); 0.4% B foliar spray (FB2); 1 mg·kg−1B + 0.2% B foliar spray (SB1 + FB1); 1 mg·kg−1B + 0.4% B foliar spray (SB1 + FB2); 2 mg·kg−1B + 0.2% B foliar spray (SB2 + FB1); 2 mg·kg−1B + 0.4% B foliar spray (SB2 + FB2); 3 mg·kg−1B + 0.2% B foliar spray (SB3 + FB1); 3 mg·kg−1B + 0.4% B foliar spray (SB3 + FB2). Each treatment has three replications, one pot having two plants per replication.ResultsB nutrition at all levels and methods of application significantly (P ≤ 0.05) affected the growth, physiological, yield, and fiber quality characteristics of both cotton cultivars. However, SB2 either alone or in combination with foliar spray showed superiority over others, particularly in the non-Bt cultivar which responded better to B nutrition. Maximum improvement in monopodial branches (345%), sympodial branches (143%), chlorophyll-a (177%), chlorophyll-b (194%), photosynthesis (169%), and ginning out turn (579%) in the non-Bt cultivar was found with SB2 compared with CK. In Bt cultivar, although no consistent trend was found but integrated use of SB3 with foliar spray performed relatively better for improving cotton growth compared with other treatments. Fiber quality characteristics in both cultivars were improved markedly but variably with different B treatments.ConclusionB nutrition with SB2 either alone or in combination with foliar spray was found optimum for improving cotton's growth and yield characteristics.
Eukaryotic translation initiation factor eIF4E-5 is required for spermiogenesis inDrosophila melanogaster
Authors: Shao Lisa , Fingerhut Jaclyn M. , Falk Brook L. , Han Hong , Maldonado Giovanna , Qiao Yuemeng , Lee Vincent , Hall Elizabeth , Chen Liang , Polevoy Gordon , Hernández Greco , Lasko Paul , Brill Julie A. 
Published: January 2023

ABSTRACTDrosophila sperm development is characterized by extensive post-transcriptional regulation whereby thousands of transcripts are preserved for translation during later stages. A key step in translation initiation is the binding of eukaryotic initiation factor 4E (eIF4E) to the 5′ mRNA cap. In addition to canonical eIF4E-1, Drosophila has multiple eIF4E paralogs, including four (eIF4E-3, -4, -5, and -7) that are highly expressed in the testis. Among these, only eIF4E-3 has been characterized genetically. Here, using CRISPR/Cas9 mutagenesis, we determined that eIF4E-5 is essential for male fertility. eIF4E-5 protein localizes to the distal ends of elongated spermatid cysts, and eIF4E-5 mutants exhibit defects during post-meiotic stages, including a mild defect in spermatid cyst polarization. eIF4E-5 mutants also have a fully penetrant defect in individualization, resulting in failure to produce mature sperm. Indeed, our data indicate that eIF4E-5 regulates non-apoptotic caspase activity during individualization by promoting local accumulation of the E3 ubiquitin ligase inhibitor Soti. Our results further extend the diversity of non-canonical eIF4Es that carry out distinct spatiotemporal roles during spermatogenesis.
Special congenital dacryocystocele
Authors: Han Li-po , Wang Feng-xian , Zhang Cheng-yue 
Published: January 2023

Congenital Dacryocystocele is a rare disease of the eye and nose, which originates from congenital obstruction of lacrimal duct system, but accounts for a low proportion in congenital obstruction of lacrimal duct system. We present a case of congenital dacryocystocele to analyze the clinical features and to explore the clinical treatment effect of special congenital dacryocyst protrusion.
doi: https://doi.org/10.12669/pjms.39.2.6819
How to cite this: Han L, Wang F, Zhang C. Special congenital dacryocystocele. Pak J Med Sci. 2023;39(2):---------. doi: https://doi.org/10.12669/pjms.39.2.6819
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Effect of Butylphthalide combined with Oxiracetam on cognitive function, Intellectual recovery and serum inflammatory factors in patients with cognitive impairment after cerebral infarction
Authors: Jiang Wenxin , Yu Xiao-dong , Deng Yanqing 
Published: January 2023

Objective: To evaluate the effect of butylphthalide combined with oxiracetam on cognitive function, intellectual recovery and serum inflammatory factors in patients with cognitive impairment after cerebral infarction.
Methods: This is a Clinical comparative study. A total of 80 patients with cognitive impairment after cerebral infarction who visited Renmin Hospital, Hubei University of Medicine from January 2020 to January 2022 were enrolled and randomly divided into two groups. Patients in the control group were treated with oral oxiracetam combined with routine treatment. Patients in the study group were given butylphthalide combined with oxiracetam on the basis of routine treatment. Compare the clinical effect, cognitive function and intellectual recovery, inflammatory factor level changes, CBV, CBF, MTT and other cerebral blood flow perfusion indicators, as well as post-treatment incidence of adverse drug reactions in the two groups of patients.
Results: The efficacy of the study group was significantly higher than that of the control group (p=0.03). After treatment, the levels of CBV and CBF in the study group were higher than those in the control group, the levels of TNF-α, CRP and IL-6 were significantly lower than those of the control group, while MTT was shorter than that in the control group, with statistically significant difference (p=0.00). Furthermore, there was a statistically significant difference that the MMSE score and MOCA score of the study group were higher than those of the control group (p=0.00).
Conclusion: Butylphthalide combined with oxiracetam has an obvious curative effect in the treatment of patients with cognitive impairment after cerebral infarction. It is a safe and effective therapeutic option that can significantly recover cognitive function and intelligence, improve cerebral blood flow perfusion and reduce inflammatory factors, without an obvious increase in adverse reactions.
doi: https://doi.org/10.12669/pjms.39.2.6901
How to cite this: Jiang W, Yu X, Deng Y. Effect of Butylphthalide combined with Oxiracetam on cognitive function, Intellectual recovery and serum inflammatory factors in patients with cognitive impairment after cerebral infarction. Pak J Med Sci. 2023;39(2):---------. doi: https://doi.org/10.12669/pjms.39.2.6901
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Model predictive control of sun-coupled innovative heat pumps: a comparison of economic and environmental optimizations
Authors: Roure Robin , Chèze David , Vallée Mathieu 
Published: January 2023

Background: Heating and cooling in buildings represents a significant amount of the energy demand in the EU, but the market penetration of renewable solutions is still marginal. The SunHorizon project aims at proving the viability and benefits of innovative coupling between heat pumps and various advanced solar panels. Methods: This study focuses on the optimal operation strategies of a technological package composed of hybrid photovoltaic thermal (PVT) panels, a gas driven heat pump and a hot water storage tank. In this work, a model predictive control is developed, based on mixed integer linear programming (MILP) optimization. This model uses innovative elements compared to traditional model predictive control (MPC), with environmental indicators for the electricity grid accounting for imports, co-simulation with TRNSYS using the transmission control protocol (TCP) and modelling of inter-seasonal storage for long and short-term decisions. The usual minimization of costs is compared to two new optimization approaches, which aims to minimize greenhouse gas (GHG) emissions and maximizing renewable use. Results and conclusions: The results of the optimization of costs and GHG emissions show that gains can be found within the variations in time series related to the electricity grid, but the overall operation strategies remain similar. Optimization of renewable share and self-consumption is another path for control strategy, but with less economic and environmental performance.
Scoping review protocol on research prioritisation for preparedness and response to outbreaks of high consequence pathogens
Authors: Antonio Emilia , Chepkirui Dorothy , Levanita Shanthi , Ibrahim Susan Khader , Foster Isabel , Harriss Eli , Sigfrid Louise , Norton Alice 
Published: January 2023

Background: Prioritisation of research activities for infectious disease pathogens is usually undertaken through the identification of important research and knowledge gaps. Research prioritisation is an essential element of both effective responses to disease outbreaks and adequate preparedness. There is however currently no published mapping of activities on and evidence from research prioritisation for high consequence pathogens. The objectives of this review are to map all published research prioritisation exercises on high-consequence pathogens; provide an overview of methodologies employed for prioritising research for these pathogens; describe monitoring and evaluation processes for research areas prioritised; and identify any standards and guidance for effectively undertaking research prioritisation activities for high consequence pathogens. Methods: The Joanna Briggs Institute guidance of scoping review conduct will be used. The search will be undertaken using the key terms of “research prioritisation”, “response”, “control”, and related terms, and a list of high-consequence pathogens derived from WHO (2020), EMERGE (2019), Europe CDC (2022) and the Association of Southeast Asian Nations (2021). We will search WHO Global Index Medicus; Ovid Medline; Ovid Embase; Ovid Global Health; and Scopus. Backward citations review of the included full text documents will also be conducted. Google Scholar and Overton will be searched for grey literature. Two independent reviewers will screen the retrieved documents using Rayyan and extract data in a data extraction template in Microsoft Excel 2021. Screening results will be presented using the PRISMA-ScR template with narrative synthesis undertaken for the extracted data. Conclusion: This review will map existing research priorities for high consequence pathogens. Further, it will provide an understanding of methodologies used for prioritisation, processes for monitoring and evaluation of progress made against research agendas, and evidence on standards that could be recommended for effective prioritisation of research for high consequence pathogens.