bluuebunny/crossref_metadata_2025_split huggingface dataset:
CTSS is associated with immunity and affects prognosis in pan-cancer
Authors: Zhang De-yun , Liu Yu , Chen Zhongjun , Zheng Jinyu , Zhao Zongren 
Published: May 2023

Abstract
Background: CTSS(Cathepsisn S) is a lysosomal cysteine protease which is found in many tissues and plays multifarious roles. However, the role of CTSS in tumorigenesis is poorly defined. We investigated the association between CTSS levels and prognosis of cancer patients to determine prognostic value in this study.
Methods: In this study, the RNA-sequencing (RNA-Seq) gene expression profile and clinical data were downloaded from the TCGA database and the UCSC database. Immunohistochemical images of CTSS and its expression in normal tissues were obtained from HPA database.Statistical analysis and data visualization were performed on the relationship between CTSS expression and prognosis, TMB,MSI, immune score, immune checkpoint and enrichment pathway through R language version 4.1.1 and its additional package.
Results:Overall, CTSS is differentially expressed in most cancers and adjacent normal tissues.In addition, multiple survival analyses showed that CTSS significantly affected patient prognoses.CTSS was strongly associated with TMB in 8 cancers and MSI in 12 cancers. In addition, CTSS expression level is positively correlated with immune score in many cancers. Finally, GSEA analysis showed that CTSS was closely related to cell cycle, immune function, JAK-STAT and other biological functions and signaling pathways
Conclusion:In some tumor patients, the high expression of CTSS can be used as a biomarker with better prognosis.In contrast, high CTSS expression indicated poor prognosis in some tumors, especially in LGG. The relationship between CTSS and immune checkpoint and GSEA analysis of CTSS may provide some ideas for potential immunotherapy and related pathways of some tumors.
Endoscopic-assisted Laparoscopic Anterior Resection of Intussuscepting Primary Colonic Liposarcoma Shortened version: Endolap-assisted Anterior Resection of a Liposarcoma
Authors: Yeo Delphina Boon Xue , Lie Darius Aw Kang , Koh Frederick Xiang Hong , Foo Fung Joon , Ng Jia Lin 
Published: May 2023

Abstract
Background: Liposarcomas are uncommon malignant mesenchymal tumours arising in the extremities and sometimes in the retroperitoneum.
Methods: We discuss a case of a rare sigmoid colon liposarcoma in a lady who presented with constipation and tenesmus.
Results: In the case of a large liposarcoma, it is difficult to maneuver the mass without the risk of serosal tears. As we make an attempt in minimally-invasive surgery for this patient, we decided that it would be useful to utilize endoscopy to help reduce the mass and attempt to resect the mass laparoscopically without extensive serosal tears.
Conclusion: A hybrid endoscopic-laparoscopic high anterior resection can help to manipulate the large tumour and avoid a low anastomosis, thereby reducing the risk of an anastomotic leak when compared to a higher anastomosis.
Isolation And Molecular Characterization of Infectious Laryngotrachitis virus from Poultry in and Bishoftu town and the bordering District Liban Cuqala
Authors: Marga Galana Biratu 
Published: May 2023

Abstract
Infectious Laryngotrachitis is an important respiratory disease of chicken caused by gallid herpes virus-І belonged to family Herpesviridae, subfamily Alphaherpesvirinae, genus Iltovirus The disease has little or no previous documented data in the country. The study was conducted from November 2022 to June 2022 by a cross-sectional study design with purposive sampling strategy. In this study, a molecular detection of ILTV were conducted generally in 12 pooled samples out of the total 40 poultries sampled from peasant Associations (PAs) of in and around Bishoftu town and the bordering district Liban Cuqala. Swab samples from upper trachea and tracheal tissue samples were collected from the selected PAs in the study area. From the total 12 pooled samples, 3 samples were positively detected for the presence of Infectious Laryngotrachitis.The study revealed an overall PCR detection of 25%. Three strains of ILT namely ICP4, TCO low and TCO high were detected with the general master mix that can bind with all of the ILT strains. Generally, ILTV were one of the serious avian respiratory pathogen challenging the study areas resulted in high economic losses. Control and prevention measures through vaccination programmed should schedule within the viral strains.
Examining the Patenting Activities of Universities in the Middle East and North Africa
Authors: El-Ouahi Jamal 
Published: May 2023

Abstract
This paper aims to examine universities' patenting activities in the Middle East and North Africa region. Patent data from Derwent Innovation is analyzed to provide key insights about such activities. Saudi Arabia leads the region in terms of the number of patents, followed by Turkey and Morocco. These three countries, which represent 87% of all academic patents, are also home to the most patenting academic institutions. Although the academic sector in MENA grew its patenting activity faster than the world, its patent volume base is still relatively low. The results also show the profile of the technological developments covered in MENA academic patents. Some of these inventions directly tackle societal health-related issues but also public environmental ones. The main academic assignees show a certain degree of collaboration with academic and corporate organizations. This study provides important input to research managers as well as policymakers to assess the research produced by universities from a technological and economic perspective.
Law and Gift: Phenomenology of Legal Experience
Authors: Сатохіна Наталія 
Published: May 2023

The article aims to reveal the specificity of the legal as such in its difference from political or economic from a phenomenological point of view, that is, to determine what the experience of law is and what is its place in our experience as a whole.
The key assumption is that while the political and the economic are based on the logic of the equivalent, which implies the establishment of a balance based on the balance of forces or interchangeable goods, the experience of law is fundamentally anti-utilitarian and subordinated rather to the logic of excess, or gift. This idea unfolds in three stages. The first part of article detects the place of gift in human experience. The next one is about the place of law in fundamental experience and the relationship between the experience of law and the experience of gift. In the final part, the question of the transformation of human experience and the corresponding perspectives of law is raised.
The author argues that law is rooted in the structure of our fundamental experience or way of being in the world. The latter consists in the openness to the infinite otherness of the Other and, in this sense, is subject to the logic of the gift. At the same time this openness is never guaranteed, which gives rise to the experience of law. Aimed at maintaining the logic of excess or gift, law turns out to be not just one of the aspects of experience, but a condition of experience as such. However, today, in the conditions of the spread of the market and its inherent logic of equivalence to all spheres of life, the experience of law, subject to the opposite idea, and with it the experience as such, appears to be under threat.
The Body as Norm: Non-Classic Ontology of Law
Authors: Stovba Oleksiy 
Published: May 2023

The article is dedicated to the reasoning of the norm of law. Traditionally norm of law was interpreted as the rule, which is fixed in legislation and guaranteed by the state coercion. The other variant of interpretation were reasonably grounded ideal rules of natural law. In the sociological doctrine law presents itself as the custom, exists implicitly in the social relations. But all the similar approaches leave without an answer the next question: in what way the ordinary people, who belong to the different legal cultures and traditions and even not imagine themselves the legal content of norms, are able to have the common and coinciding picture of law.
In my opinion to explain the similar state affairs we have to reconsider norm of law in its ontological aspect. It means to grasp and to contemplate how the norm of law exists in the real world, not on the paper or in mind of theorists and legal philosophers. The similar ontological turn becomes possible due to the phenomenological philosophy. We are talking not only about the works of classic phenomenologists, as Edmund Husserl or Moris Merlo-Ponty, but also about the “third wave of phenomenology,” such as Marc Rishire or Gean Marion. The classical phenomenology is first of all, the doctrine of consciousness. In its turn, contemporary phenomenologist’s focal point shifts toward human body. The latter isn’t interpreted as material embodiment of active subject, but opposite as the passive, affected. The body in its case becomes the field of experience, describing of which is possible through the phenomenological method.
In the legal aspect it means, that the genuine restriction of the human deeds is rooted in the living corporal presence of the other people and not in the positive legislation or natural law. The living corporal presence of the Other in the common Being becomes the measure of my deeds. The similar measure is the border, limit and modality of my deeds towards the Others. Thus, the body of human Being takes the place of a positive or natural norm of law and, in strictly sense, embodies the norms of permeated, ought or demanded behavior. At the same time human body contents in itself all the parts of legal norm – its disposition, sanction and hypothesis and then turns into the genuine modus of legal norm’s existence.
Two Concepts of Dignity: On the Decay of Agency in Law
Authors: Melkevik Åsbjørn , Melkevik Bjarne 
Published: May 2023

This paper examines the radical shift we can observe in the modern legal understanding of dignity. That one should be respected for one’s own sake is a cornerstone of our modern societies, enshrined in our laws and constitutions. The idea of dignity, however, is subject to fundamentally different interpretations. More precisely, we examine two such theories of dignity – namely, the “agency theory of dignity,” associated with Immanuel Kant and based on people’s capacity for free will, and the “well-being theory of dignity,” recently championed by Alan Gewirth and regarding dignity a kind of intrinsic worth that belongs equally to all human beings as such. Kantian dignity means that we should endorse strong negative duties, but not positive duties, such as duties of welfare. From Gewirth’s one we can derive rights not only of negative freedom, but also duties of well-being toward others.
The modern shift from the former to the latter, we argue, is problematic, first, inasmuch as it is an expression of the decay of agency in our legal systems, and, second, because the well-being theory of dignity is often self-defeating, hurting the well-being of the worst-off and lowering total welfare in society. This paper accordingly maintains that we should go back to the agency theory of dignity.
Using an antinomian reading of Kant’s theory, we maintain that rational people are to be their own lawmaker and act from laws they themselves made, that the scope of legislative activity should be limited as a matter of dignity, and the role of dignity should be reduced in our laws. The main conclusion is that dignity cannot be a principle of law, as it is rather a principle of responsibility.
Electric Discharge Machining of AA7075/SiCP/B4CP Hybrid Composites machined with Al2O3 Mixed Used Engine Oil Dielectric fluid
Authors: Nayak Bijaya Bijeta , Bhat Suriya Shaffi , Gummadi Anand Kumar , Latha A. , Ganesan R. , H. Jehad Marowah , Almashhadani Haider Abdulkareem , Sahu Santosh Kumar 
Published: May 2023

Background:
Machining hybrid composites through conventional machining technique was a challenging task as it produces excessive tool wear and exhibits poor surface roughness. In this research work, an attempt was made to electric discharge machining of AA7075/SiCP/B4CP Hybrid Composites produced through the stir casting route.

Objective:
The used engine oil was as the dielectric fluid with the objective of obtaining wealth from waste. The experiments were performed by varying distinct Electric Discharge Machining (EDM) process parameters with the goal of obtaining a high Material Removal Rate (MRR), low Tool Wear Rate (TWR) and least Surface Roughness (Ra). The experimental runs were optimized using the Technique for Order of Preference by Similarity to Ideal Solution (TOPSIS) optimization techniques.

Methods:
Experimental runs were designed using the L20 Taguchi orthogonal array in which Powder concentration, Current and Pulse on time were varied for three different levels, and two various dielectric fluids were used for investigation. The characteristics of the Used Engine Oil (UEO) were assessed to find its feasibility as a dielectric fluid.

Results:
In comparison to EDM oil, the specimen machined in UEO dielectric medium has a somewhat greater MRR. Regardless of the kind of dielectric fluid employed, adding Al2O3 particles increases the MRR because of the bridging effect. Due to its high thermal conductivity, UEO oil produced electrodes with a TWR that was greater than that of EDM oil. The TWR decreases with the addition of Al2O3 particles due to an increase in the spark gap. In comparison to EDM oil, the specimen machined under UEO displays a lower Ra value. Ra decreases with the inclusion of Al2O3 particles due to the thorough flushing of machining waste.

Conclusion:
The specimen machined under Al2O3 mixed UEO dielectric medium, with the process parameters tuned at 3A current and 20µs Ton, offers better machining performance and was recommended for EDM sector.
Perbandingan Metode Cost Sensitive pada Decision Tree dan NaÃ¯ve Bayes untuk Klasifikasi Data Multiclass
Authors: Febriantono M Aldiki , Pramono Sholeh Hadi , Rahmadwati Rahmadwati 
Published: May 2023

Abstrakâ€“ Knowledge discovery is the method of extracting information from data in making informed decisions. Seeing as classifiers do have a lot of learning patterns in the data, testing an imbalanced dataset becomes a major classification issue. The cost-sensitive approach on the decision tree C4.5 and nave Bayes is used to solve the rule of misclassification. The glass, lympografi, vehicle, thyroid, and wine datasets were collected from the UCI Repository and included in this analysis. Preprocessing attribute selection with particle swarm optimization was used to process the data collection. Besides, the cost-sensitive decision tree C4.5Â and the cost-sensitive naive Bayes method were used in the research. On the glass, lympografi, vehicle, thyroid, and wine datasets, the accuracy of the test results was 72.34 %, 68.22 %, 75.68 %, 93.82 %, and 93.95 %, respectively, using the cost-sensitive decision tree C4.5. While the cost-sensitive naive Bayes method outperforms the others by 32.24 %, 82.61 %, 25.53 %, 97.67 %, and 94.94 % on the dataset, respectively.
Sistem Deteksi Cuaca Berdasarkan Analisis Histogram HCL Menggunakan Algoritma k-Nearest Neighbor ( KNN )
Authors: Hariani Siti 
Published: May 2023

Abstrak - Belakangan ini cuaca ekstrim yang berubah â€“ ubah yang tidak dapat ditebak sering terjadi yang mengganggu aktivitas sehariÂ - hari. Untuk itu diperlukan suatu sistem yang dapat mendeteksi kondisi cuaca berdasarkan citra awan.Â Oleh Karena penulis pada penelitian ini akan membuat sistem pendeteksi kondisi cuaca berdasarkan citra awan. Pada sistem ini, penulis akan melakukan penelitian dengan melalui video digital yang direkam menggunakan Handphone yang di lengkpai dngan fiture perekam video untuk mendaptkan citra pada awan. Penulis akan melakukan perekaman kondisi cuaca awan sekitar dalam waktu yang singkat hanya dalamÂ jangka waktu 5 menit. Setelah itu video yang telah direkam akan diekstraksi ciri dengan metode histogram warna terhadap citra awan yang telah ditangkap oleh Camera vido digital. Kemudian dilakukan proses klasifikasi menggunakan algoritma k-Nearest Neighbor. Algoritma klasifikasi yang digunakan dalam tugas akhir ini adalah k-Nearest Neighbor, yang diharapkan mampu untuk mengenali citra awan dan mengklasifikasi kondisi cuaca. Berdasarkan pengujian yang dilakukan, sistem menghasilkan tingkat akurasi sebesar 84,21%. Kondisi cuaca yang diprediksi adalah kondisi cerah berawan, berawan, hujan, malam cerah dan malam hujan.
Predicting Internet Use and Digital Competence Among Older Adults Using Performance Tests of Visual, Physical, and Cognitive Functioning: Longitudinal Population-Based Study
Authors: Heponiemi Tarja , Kainiemi Emma , Virtanen Lotta , Saukkonen Petra , Sainio Päivi , Koponen Päivikki , Koskinen Seppo 
Published: May 2023

Background
The rapidly increasing role of the internet in obtaining basic services poses challenges, especially for older adults’ capabilities of getting the services they need. Research on the predictors of older adults’ internet use and digital competence is especially relevant given that people are living longer than before, and the age profile of many societies is changing rapidly.

Objective
We aimed to examine the associations of objective measures of physical and cognitive impairment with the nonuse of the internet for services and low digital competence among older adults.

Methods
A longitudinal population-based design was used that combined data from performance tests and self-rated questionnaires. Data were gathered in 2017 and 2020 among 1426 older adults aged between 70 and 100 years in Finland. Logistic regression analyses were used to examine the associations.

Results
Those who had poor near (odds ratio [OR] 1.90, 95% CI 1.36-2.66) or distant vision (OR 1.81, 95% CI 1.21-2.71), restricted or failed abduction of upper arms (OR 1.81, 95% CI 1.28-2.85), and poor results from the word list memory (OR 3.77, 95% CI 2.65-5.36) or word list delayed recall (OR 2.12, 95% CI 1.48-3.02) tests had greater odds for nonuse of the internet for services than their counterparts. Moreover, those who had poor near (OR 2.18, 95% CI 1.57-3.02) or distant vision (OR 2.14, 95% CI 1.43-3.19), poor results from the chair stand test (OR 1.57, 95% CI 1.06-2.31), restricted or failed abduction of upper arms (OR 1.74, 95% CI 1.10-2.76), and poor results from the word list memory (OR 3.41, 95% CI 2.32-5.03) or word list delayed recall (OR 2.05, 95% CI 1.39-3.04) tests had greater odds of low digital competence than their counterparts.

Conclusions
According to our results, older adults’ impaired physical and cognitive functioning may hamper their possibilities of accessing internet services such as digital health care services. Our results should be considered when planning digital health care services intended to be used by older adults; that is, digital solutions should also be suitable for older adults with impairments. Furthermore, face-to-face services should be provided for those who cannot use digital services, even if they are assisted properly.
MONITORING SUHU BAWAH PERMUKAAN DENGAN SISTEM MASTER SLAVE
Authors: Arifuddin Rahman , Hakim Ermanu Azizul 
Published: May 2023

Meningkatnya kebutuhan akan energy dimasa ini memberikan peluang untuk mengeksporasi sumber energy terbarukan. Menipisnya persediaan energy tidak terbarukan seiring dengan meningkatnya perminataan dan penggunaanya, diperlukan sumber energy terbarukan. Sumber panas bumi dapat menjadi salahsatu alternative enregi terbarukan, dengan melakukan eksplorasi terhadap daerah yang memiliki potensi. Pengukuran suhu bawah permukaan dapat menjadi langkah awal untuk mendapatkan data panas bumi, yang akan menjadi acuan daerah ukur memiliki potensi panas bumi yang bisa dijadikan energy alternative. System ini dibangun dengan menggunakan system master slave, menggunakan radio frekuensi untuk system komunikasi dan monitoring hasil pengukuran suhu bawah permukaan berupa table serta bentuk kontur. Pengukuran suhu bawah permukaan didapatkan hasil suhu yang terdeteksi berkisar antara + 25OC pada sensor 1 masing-masing slave dan + 26OC – 27OC pada sensor 4 pada masing-masing slaveKata kunci: monitoring, master slave, suhu bawah permukaan
EVALUASI KINERJA LPWA BERBASIS INTERNET OF THINGS MENGGUNAKAN RADIO FREKUENSI LORA 915 MHz DAN 920 MHz
Authors: Adi Puput Dani Prasetyo , Effendy Machmud 
Published: May 2023

Teknologi perangkat Wireless Sensor Network (WSN) terus dikembangkan dalam konsumsi daya, ukuran atau dimensi, dan fungsionalitas (medis, monitor cuaca, pergerakan sapi peliharaan, pemantauan titik kebakaran hutan, dll.), Perangkat WSN memiliki 3 kriteria berikut , yaitu, Konsumsi Daya Rendah, Transmisi Data Kecepatan Tinggi, Jarak Jauh. Selanjutnya LoRa, memiliki Konsumsi Daya Rendah dan kemampuan pengiriman data Jarak Jauh (km), Kecepatan Rendah Data Rate atau Transmisi Data (bps). LoRa tidak dapat mengirim data Payload berkapasitas besar seperti file video, musik, atau Gambar. Namun dilihat dari faktor fungsionalitas, LoRa adalah perangkat Radio Frequency (RF) untuk mengirimkan data sensor dengan Bit Rate atau Data Rate (bps) yang rendah untuk pemantauan kesehatan manusia, penderita disabilitas, mengutamakan korban bencana berdasarkan konsep triase menggunakan sensor denyut, dan sensor lainnya seperti data Suhu, SPO2, dan Tekanan Darah, pada penelitian ini difokuskan pada denyut jantung (bpm), oleh karena itu perangkat Low Power Wide Area (LPWA) direalisasikan dengan analisis rinci. Perangkat ini berkomunikasi dengan Gateway atau Application Server, oleh karena itu, komunikasi Uplink dan Downlink terjadi, secara umum, perangkat WSN yang berkomunikasi satu sama lain ini disebut dengan Internet of Things (IoT). Pada IoT terdapat ribuan perangkat sensor node yang terhubung ke Gateway atau server Internet, oleh karena itu perlu adanya manajemen untuk menjaga agar sensor Node atau WSN tetap hidup dalam waktu yang lama, penelitian ini juga membahas tentang pendekatan topologi pada WSN. untuk mengatur Konsumsi Daya node Sensor. Kata kunci: lora, monitoring, power,consumption, IoT, WSN
PENERAPAN SENSOR PEDETEKSI DINI GEMPA BUMI PADA BANGUNAN KONSTRUKSI
Authors: Witjaksana Budi , Amal Andi Syaiful 
Published: May 2023

Deteksi dini adanya gempa bumi pada konstruksi bangunan merupakan bagian penting sebagai langkah antisipatif mandiri yang dapat memberikan informasi persuasif yang cepat dan akurat dalam memberikan jaminan terhadap keselamatan pengguna konstruksi bangunan. Frekwensi dan intensitas kegempaan di Indonesia khususnya di Jawa Timur menunjukkan bahwa semakin tahun semakin meningkat, sehingga diperlukan sebuah alat yang dapat memberikan informasi dengan cepat dan tepat dan sekaligus murah . Dalam penelitian ini akan direncanakan dan dibuat suatu perangkat elektronik yang dapat diterapkan untuk mendeteksi dini adanya gempa pada kontruksi bangunan secara umum terutama pada konstruksi bangunan gedung bertingkat, perangkat ini mengaplikasikan sensor proximity sebagai pedeteksi gempa bumi berupa getaran horizontal. Sensor pendeteksi dini gempa bumi berdasarkan mekanisme rambat getaran dan disesuakan dengan range pada skala richter akan secara otomatis akan mengaktifkan sistem keamanan gedung bertingkat.. Hasil penelitian ini mendapatkan suatu perangkat tepat guna yang dapat diterapkan pada gedung bertingkat sebagai deteksi dini pada 4 magnitudo, sehingga para pengguna yang berada didalamya dapat menyelamatkan diri jika akan adanya gempa bumi dan menuju ke tempat yang aman sesuai protokol keselamatan." Kata kunci : gempa bumi, sensor, gedung bertingkat