bluuebunny/crossref_metadata_2025_split huggingface dataset:
Thromboembolic toxicity observed with concurrent trametinib and lenalidomide therapy
Authors: Chan Priya P. , Sabus Ashley , Hemenway Molly S. , Chatfield Kathryn C. , White Christina J. , Mirsky David M. , Foreman Nicholas K. , Dahl Nathan A. 
Published: January 2023

AbstractThe event‐free survival of pediatric low‐grade gliomas is poor, and patients often require multiple treatment strategies. While MEK and RAF inhibitors are efficacious in early‐phase trials, not all patients respond, and many experience progression following completion of therapy. Evaluating combination therapies that may enhance efficacy or prolong disease stabilization is warranted. We report our institutional experience using concurrent trametinib and lenalidomide in the treatment of primary pediatric central and peripheral nervous system tumors. Two of four patients using this combination therapy experienced severe thromboembolic events, necessitating discontinuation of therapy. This combination requires further investigation, and we urge caution if used.
Creep properties and damage mechanism of molded glass fiber reinforced plastic
Authors: Li Jikang , Liu Zheng , Li Yajing , Zhao Yongzhong , Wang Min , Wang Hongtao , Chen Xu 
Published: January 2023

AbstractGlass fiber reinforced plastic (GFRP) has become one of the most commonly used materials in the structure of aero engines in the last decades. In this study, GFRP was fabricated by molding with phenolic resin as the matrix. Specimens were prepared along horizontal and vertical directions. Fiber distribution, tensile properties, long‐term creep performance, and damage mechanism were systematically investigated. Experimental results shows that horizontal specimens have better tensile properties, lower viscoelasticity, and excellent creep resistance. The fibers inside the cylindrical material exhibit a 3D core‐shell morphology with transverse isotropy in the core region. Load is carried by the fibers and the damage is in the form of fiber fracture and pull‐out in horizontal specimens. Random distribution and interweaving leads to double fracture sections of fibers. Load is carried by the interface and resin, and the damage is in the form of fiber pull‐out laterally and interfacial debonding in vertical specimens. High viscoelasticity of the resin and the weak interfacial bonding ability lead to large creep deformation of vertical specimens. In addition, the creep strain under different loads can be accurately predicted by Modified Time Hardening model.
Synthesis of hydrazine‐fumaryl chloride‐based polyamide and its electrical conductivity studies
Authors: Yadav Shashikant , Tiwari Rudramani , Verma Dipendra Kumar , Kumar Devendra , Adhikary Pubali , Krishnamoorthi Subramanian 
Published: January 2023

AbstractPerfect crisscross chain arrangements with high inter‐chain H‐bonding structure of conjugated polyamides are capable of inter‐chain proton transfer and this property of conjugated polyamides makes them semiconducting material. To establish this, we synthesized in situ HCl doped Hydrazine‐Fumaryl Polyamide (HFP) material via the condensation polymerization method. HFP was further modified by doping with Lewis acids BF3 and AlCl3 to increase the amorphous nature and ionic conductivity. Among the synthesized material, HFP–AlCl3 showed the highest amorphous property with the best bulk conductivity in the order of 10−5 S/cm at room temperature. HFP and doped HFP showed correlated hopping type (n < 1) ionic dynamics in the polymer matrix. There was a high amount of charge associated with the polymer matrix (>106 F/m) with negligible electrode‐electrolyte effect contribution. These properties of materials can make them useful in the field of organic voltaic and fuel cell applications.
Study on the evaluation and compensating strategy for the wear damage of non‐return valve during injection molding process
Authors: Ma Yitao , Xu Yuxuan , Dang Kaifang , Fu Nanhong , Jiao Xiaolong , Xie Pengcheng , Yang Weimin 
Published: January 2023

AbstractInjection molding (IM) is one of the most essential forming methods for plastics. However, some potential risks which influence part quality may occur in the molding process. A non‐return valve (NRV) is a major component on the screw head whose function is to seal during the injection process to prevent the backflow of the melt. The NRV will wear in this process and cause fluctuations in parameters and quality but the wear states of NRVs cannot be monitored without the disassembly of the injection barrel. In this study, we proposed an optimization method to compensate for the wear damage of the NRVs. The V/P switchover point in each molding cycle was recalculated and output to stabilize the part quality. As a result, the wear damage of the NRV on the current machine was able to be predicted and the part quality could be initially optimized in the condition that the NRV had a degree of wear. The experimental results reveal that our proposed compensation algorithm can monitor the type of wear of NRV online, and at the same time, it can compensate the axial wear of NRV and finally improve the consistency of product weight, which established a fundamental for further research in the future.
Registration of ‘CP 14‐1377’ sugarcane for organic soils in Florida
Authors: Sood Sushma , Momotaz Aliya , Baltazar Miguel , Coto Arbelo Orlando , Davidson R. Wayne , Islam Md. S. , Sandhu Hardev S. , Zhao Duli , Gordon Vanessa S. 
Published: January 2023

Abstract‘CP 14‐1377’ (Reg. no. CV‐211, PI 700115), a new sugarcane (a complex hybrid of Saccharum spp.) cultivar, was developed through cooperative research conducted by the USDA‐ARS, the University of Florida, and the Florida Sugar Cane League, Inc. CP 14‐1377 was selected from the polycross (X12‐1500) between CP 03‐1094 and Poly12‐29 (several males) made at Canal Point, FL on 20 Dec. 2012. It was released for cultivation on organic soils in June 2021 because of its higher stalk population, sugar yield, and economic index (profitability) than the reference check, ‘CP 96‐1252’. The cane fiber content of CP 14‐1377 (137.00 kg Mg−1) was 3% higher than that of CP 96‐1252 and 2% lower than that of ‘CP 00‐1101’ and ‘CPCL 05‐1201’. At the time of its release, CP 14‐1377 was resistant to brown rust [caused by Puccinia melanocephala (H. & P. Sydow)], orange rust [caused by Puccinia kuehnii (E.J. Butler)], smut [caused by Sporisorium scitamineum (Syd., M. Piepenbr., M. Stoll & Oberw)], mosaic (caused by Sugarcane mosaic virus strain E), and ratoon stunt disease [caused by Leifsonia xyli subsp. xyli (Evtsuhenko et al.)]. It was also moderately resistant to leaf scald [caused by Xanthomonas albilineans (Ashby, Dowson)] and Sugarcane yellow leaf virus. It had an acceptable level of freeze tolerance for Florida. CP 14‐1377 had yield and disease traits superior to the widely grown cultivar CP 96‐1252; therefore, CP 14‐1377 has the potential to positively affect sugarcane production in Florida.
Implementation of a comprehensive pharmacy‐driven immunization care process model in a pediatric cystic fibrosis clinic
Authors: Zobell Jeffery T. , Moss Justin , Creelman Jenna , Christensen Rilee , Jensen Bevan , Stewart Jennifer , Ameel Kristen , Asfour Fadi 
Published: January 2023

AbstractIntroductionMembers of an integrated pharmacy team (pharmacists and pharmacy technicians) have roles that have been identified in the literature as part of the multi‐disciplinary cystic fibrosis (CF) care team. One role that has not specifically addressed is the administration of routine and recommended immunizations to people with CF (PwCF). According to care guidelines, PwCF of all ages should be provided all age‐appropriate and recommended immunizations. Pharmacists and pharmacy technicians can administer immunizations per state laws. The Primary Children's CF Center decided to implement a comprehensive pharmacy‐driven immunization care process model to impact immunization rates.MethodsA 24‐month retrospective analysis was conducted with pediatric (≤18 years) PwCF at the Primary Children's CF Center. The primary outcome measures were the percentage (%) of PwCF who received PPSV23, and/or HPV, and/or meningococcal conjugate vaccine (MCV) immunizations 1‐year post‐care process model implementation (October 1, 2021, to September 30, 2022) as compared to baseline values. The secondary outcome measures are the total number of immunizations, the number of each immunization provided, and the financial impact of pharmacy‐driven immunization care process model 1‐year post‐implementation.ResultsDuring the 1‐year post‐care process model implementation (October 1, 2021, to September 30, 2022), a total of 523 immunizations were provided to 243 pediatric PwCF. The most frequent immunizations provided were PPSV23 (160/523, 31%) and Coronavirus Disease 2019 (COVID‐19) (154/523, 29%). The baseline percentages of eligible PwCF of PPSV23, HPV, and MCV were 27% (58/217), 43% (32/74), and 24% (8/34), respectively. The 1‐year post‐implementation percentages of PPSV23, HPV, and MCV were 99% (217/218, p < 0.00001), 91% (67/74, p < 0.00001), and 97% (33/34, p < 0.00001), respectively. For COVID‐19 immunizations, 56% of eligible PwCF (181/321) have received their first dose. Of these 181 PwCF, 70% (126/181) have received at least one dose of their primary series or booster during the 1‐year post‐implementation period. The rate of those PwCF who have received at least one dose of a COVID‐19 immunization from the age of 6 months to 4 years, 5–11 years, and 12–18 years, was 37% (30/82), 60% (78/129), and 66% (73/110), respectively. For the financial impact generated during the 1‐year immunization care process model post‐implementation period, 404 non‐VFC immunizations were given for an estimated profit of $11,930.ConclusionsThe implementation of a pharmacy‐driven immunization care process model is a way for integrated pharmacy teams to evolve with the CF center care model and have a role expansion in the care provided to PwCF.
Computational design of prospective molecular targets for Burkholderia cepacia complex by molecular docking and dynamic simulation studies
Authors: Skariyachan Sinosh , Praveen Prinith Kaveramma Uluvangada , Uttarkar Akshay , Niranjan Vidya 
Published: January 2023

AbstractThe study aimed to screen prospective molecular targets of BCC and potential natural lead candidates as effective binders by computational modeling, molecular docking, and dynamic (MD) simulation studies. Based on the virulent functions, tRNA 5‐methylaminomethyl‐2‐thiouridine biosynthesis bifunctional protein (mnmC) and pyrimidine/purine nucleoside phosphorylase (ppnP) were selected as the prospective molecular targets. In the absence of experimental data, the three‐dimensional (3D) structures of these targets were computationally predicted. After a thorough literature survey and database search, the drug‐likeness, and pharmacokinetic properties of 70 natural molecules were computationally predicted and the effectual binding of the best lead molecules against both the targets was predicted by molecular docking. The stabilities of the best‐docked complexes were validated by MD simulation and the binding energy calculations were carried out by MM‐GBSA approaches. The present study revealed that the hypothetical models of mnmC and ppnP showed stereochemical accuracy. The study also showed that among 70 natural compounds subjected to computational screening, Honokiol (3′,5‐Di(prop‐2‐en‐1‐yl) [1,1′‐biphenyl]‐2,4′‐diol) present in Magnolia showed ideal drug‐likeness, pharmacokinetic features and showed effectual binding with mnmC and ppnP (binding energies −7.3 kcal/mol and −6.6 kcal/mol, respectively). The MD simulation and GBSA calculation studies showed that the ligand‐protein complexes stabilized throughout tMD simulation. The present study suggests that Honokiol can be used as a potential lead molecule against mnmC and ppnP targets of BCC and this study provides insight into further experimental validation for alternative lead development against drug resistant BCC.
A fiducial approach for testing the non‐inferiority of proportion difference in matched‐pairs design
Authors: Chen Chao , Ye Siyang , Xu Jiahao , Wan Kai , Chen Yanting 
Published: January 2023

AbstractThe non‐inferiority of one treatment/drug to another is a common and important issue in medical and pharmaceutical fields. This study explored a fiducial approach for testing the non‐inferiority of proportion difference in matched‐pairs design. Approximate tests constructed using fiducial quantities with a combination of different parameters were proposed. Four simulation studies were employed to compare the performance of fiducial tests by comparing their type I errors and powers. The results showed that fiducial quantities with parameter performed satisfactorily from small to large samples. Therefore, the fiducial tests could be recommended for practical applications. The recommended fiducial tests might be a competitive alternative to other available tests. Three real data sets were analyzed to illustrate the proposed methods were competitive or even better than other tests.
Transpulmonary generation of cell‐free hemoglobin contributes to vascular dysfunction in pulmonary arterial hypertension via dysregulated clearance mechanisms
Authors: Meegan Jamie E. , Kerchberger Vern Eric , Fortune Niki L. , McNeil Joel Brennan , Bastarache Julie A. , Austin Eric D. , Ware Lorraine B. , Hemnes Anna R. , Brittain Evan L. 
Published: January 2023

AbstractCirculating cell‐free hemoglobin (CFH) is elevated in pulmonary arterial hypertension (PAH) and associated with poor outcomes but the mechanisms are unknown. We hypothesized that CFH is generated from the pulmonary circulation and inadequately cleared in PAH. Transpulmonary CFH (difference between wedge and pulmonary artery positions) and lung hemoglobin α were analyzed in patients with PAH and healthy controls. Haptoglobin genotype and plasma hemoglobin processing proteins were analyzed in patients with PAH, unaffected bone morphogenetic protein receptor type II mutation carriers (UMCs), and control subjects. Transpulmonary CFH was increased in patients with PAH (p = 0.04) and correlated with pulmonary vascular resistanc (PVR) (rs = 0.75, p = 0.02) and mean pulmonary arterial pressure (mPAP) (rs = 0.78, p = 0.02). Pulmonary vascular hemoglobin α protein was increased in patients with PAH (p = 0.006), especially in occluded vessels (p = 0.04). Haptoglobin genotype did not differ between groups. Plasma haptoglobin was higher in UMCs compared with both control subjects (p = 0.03) and patients with HPAH (p < 0.0001); patients with IPAH had higher circulating haptoglobin levels than patients with HPAH (p = 0.006). Notably, circulating CFH to haptoglobin ratio was elevated in patients with HPAH compared to control subjects (p = 0.02) and UMCs (p = 0.006). Moreover, in patients with PAH, CFH: haptoglobin correlated with PVR (rs = 0.37, p = 0.0004) and mPAP (rs = 0.25, p = 0.02). Broad alterations in other plasma hemoglobin processing proteins (hemopexin, heme oxygenase‐1, and sCD163) were observed. In conclusion, pulmonary vascular CFH is associated with increased PVR and mPAP in PAH and dysregulated CFH clearance may contribute to PAH pathology. Further study is needed to determine whether targeting CFH is a viable therapeutic for pulmonary vascular dysfunction in PAH.
Implementation of a double moment cloud microphysics scheme in the UK met office regional numerical weather prediction model
Authors: Field Paul R. , Hill Adrian , Shipway Ben , Furtado Kalli , Wilkinson Jonathan , Miltenberger Annette , Gordon Hamish , Grosvenor Daniel P. , Stevens Robin , Van Weverberg Kwinten 
Published: January 2023

AbstractCloud microphysics parametrizations control the transfer of water between phases and hydrometeor species in numerical weather prediction and climate models. As a fundamental component of weather modelling systems cloud microphysics can determine the intensity and timing of precipitation, the extent and longevity of cloud cover and its impact on radiative balance, and directly influence near surface weather metrics such as temperature and wind. In this paper we introduce and demonstrate the performance of a double moment cloud microphysical scheme (CASIM: Cloud AeroSol Interacting Microphysics) in both midlatitude and tropical settings using the same model configuration. Comparisons are made against a control configuration using the current operational single moment cloud microphysics, and CASIM configurations that use fixed in‐cloud droplet number or compute cloud droplet number concentration from the aerosol environment. We demonstrate that configuring CASIM as a single moment scheme results in precipitation rate histograms that match the operational single moment microphysics. In the midlatitude setting, results indicate that CASIM performs as well as the single moment microphysics configuration, but improves certain aspects of the surface precipitation field such as greater extent of light (1 mm hr) rain around frontal precipitation features. In the tropical setting, CASIM outperforms the single moment cloud microphysics as evident from improved comparison with radar derived precipitation rates.
An unusual case of interstitial lung disease: Revisiting peribronchiolar metaplasia interstitial lung disease (PBM‐ILD)
Authors: Jung Flora , Shapera Shane , Cabanero Michael , McInnis Micheal , Fisher Jolene 
Published: January 2023

AbstractPeribronchiolar metaplasia (PBM) is a histological finding of uncertain significance commonly seen in interstitial lung disease (ILD). PBM is thought to be secondary to small airway injury from insults such as tobacco smoke and other environmental exposures. The term PBM‐ILD has been proposed for patients with ILD where PBM is the major histologic finding, however a lack of radiographic changes supportive of ILD in previously reported cases has limited recognition of the diagnosis. We present a rare case of welding‐associated ILD with clinical, radiographic, and histologic evidence consistent with the proposed definition of PBM‐ILD. We outline an approach to its consideration as a diagnosis based on our experience through multidisciplinary discussion.
Robust approximate optimal control for air‐breathing hypersonic vehicle
Authors: Han Xiao , Liu Lei , Fan Huijin , Cheng Zhongtao 
Published: January 2023

AbstractThis paper investigates the robust approximate optimal control problem for air‐breathing hypersonic vehicle (AHV). By input‐output linearzation and introducing auxiliary variables, the high‐order nonlinear AHV dynamics are transformed to a second‐order feedback decoupling model. Then a virtual command is designed by back‐stepping strategy to guarantee the practical finite‐time convergence of tracking error. In order to drive the AHV with uncertainties to follow the virtual command, a robust approximate optimal controller based on adaptive dynamic programming (ADP) is proposed. Different from the conventional robust method, both the robustness and the input cost are taken into consideration in the proposed controller, which can optimize the control actions and hence avoid the chattering. Besides, the proposed controller adopts a single critic network design instead of actor‐critic structure, which ensures the stability of the system autonomously and simplifies the implementation procedure. The simulation results show the effectiveness of the proposed scheme.
Hydraulic classification of hydropeaking stages in a river reach
Authors: Burman Anton J. , Andersson Anders G. , Hellström J. Gunnar I. 
Published: January 2023

AbstractHydropower is an important tool in the struggle for low‐emission power production. In the Nordic countries, hydropower operating conditions are expected to change and work more in conjunction with intermittent power production. This in turn might increase the amount of hydropeaking events in the reaches downstream of hydropower plants. The current work investigates the influence of highly flexible, high‐frequency hydropeaking on the hydrodynamics in the downstream reach. By quantifying four different dynamic stages in the study reach, the influence of the hydropeaking frequencies was investigated in the bypass reach of the Stornorrfors hydropower plant in the river Umeälven in northern Sweden. The hydrodynamics in the study reach were numerically modelled using the open source solver Delft3D. Eight different highly flexible future hydropeaking scenarios, varying from 12 to 60 flow changes per day, were considered. A method for identifying four hydropeaking stages—dewatering, dynamic, alternating and uniform —was introduced. The hydropeaking frequency directly decided the stage in most of the study reach. Furthermore, a Fourier analysis showed a significant difference between the stages and their corresponding power spectra. The classification of stages put forward in this work provides a novel, simple method to investigate the hydrodynamics due to hydropeaking in a river reach.
Comparison of 3D structural metrics on oyster reefs using unoccupied aircraft photogrammetry and terrestrial LiDAR across a tidal elevation gradient
Authors: Ridge Justin T. , DiGiacomo Alexandra E. , Rodriguez Antonio B. , Himmelstein Joshua D. , Johnston David W. 
Published: January 2023

AbstractPhysical structures generated from ecosystem engineers can have a cascade of impacts on the ecological community and the surrounding landscape. The Eastern oyster Crassostrea virginica can form extensive intertidal reefs, whose three‐dimensional structures provide ecosystem services like nursery and foraging habitat for fishes and invertebrates and shoreline stabilization. Measurements of the structural properties of these reefs provide opportunities to quantitatively assess associated services. There is a growing variety of tools available for measuring three‐dimensional (3D) properties of intertidal habitats, including two remote sensing methods that capture 3D structural metrics in a number of environments. We surveyed reefs using a terrestrial laser scanner (TLS, LiDAR) and imagery from unoccupied aircraft systems (UAS, or drones) processed through Structure from Motion photogrammetry. Comparisons of digital elevation models from repetitive flights over an oyster reef to checkpoints yielded mean horizontal and vertical root mean square errors (RMSE) of −0.54 ± 0.47 cm and 0.97 ± 1.0 cm (Mean ± SD), respectively, indicating high accuracy among UAS surveys. Compared to TLS products, point cloud densities from UAS‐derived products were more consistent across the reef elevation gradient and much denser overall except in the low reef zone, which was proximal to most of the TLS scan locations. Comparisons of structural metrics between UAS and TLS showed similarities in metrics like profile and planform curvatures, yet indicated UAS surveys produced higher values of surface complexity and slope. Results indicate that UAS photogrammetry can produce robust oyster reef structural metrics that can be highly useful in oyster conservation and restoration.