bluuebunny/crossref_metadata_2025_split huggingface dataset:
A novel 7-chemokine-genes predictive signature for prognosis and therapeutic response in renal clear cell carcinoma
Authors: Lin Ming-Jie , Tang Xiu-Xiao , Yao Gao-Sheng , Tan Zhi-Ping , Dai Lei , Wang Ying-Han , Zhu Jiang-Quan , Xu Quan-Hui , Mumin Mukhtar Adan , Liang Hui , Wang Zhu , Deng Qiong , Luo Jun-Hang , Wei Jin-Huan , Cao Jia-Zheng 
Published: March 2023

Background: Renal clear cell carcinoma (ccRCC) is one of the most prevailing type of malignancies, which is affected by chemokines. Chemokines can form a local network to regulate the movement of immune cells and are essential for tumor proliferation and metastasis as well as for the interaction between tumor cells and mesenchymal cells. Establishing a chemokine genes signature to assess prognosis and therapy responsiveness in ccRCC is the goal of this effort.Methods: mRNA sequencing data and clinicopathological data on 526 individuals with ccRCC were gathered from the The Cancer Genome Atlas database for this investigation (263 training group samples and 263 validation group samples). Utilizing the LASSO algorithm in conjunction with univariate Cox analysis, the gene signature was constructed. The Gene Expression Omnibus (GEO) database provided the single cell RNA sequencing (scRNA-seq) data, and the R package “Seurat” was applied to analyze the scRNA-seq data. In addition, the enrichment scores of 28 immune cells in the tumor microenvironment (TME) were calculated using the “ssGSEA” algorithm. In order to develop possible medications for patients with high-risk ccRCC, the “pRRophetic” package is employed.Results: High-risk patients had lower overall survival in this model for predicting prognosis, which was supported by the validation cohort. In both cohorts, it served as an independent prognostic factor. Annotation of the predicted signature’s biological function revealed that it was correlated with immune-related pathways, and the riskscore was positively correlated with immune cell infiltration and several immune checkpoints (ICs), including CD47, PDCD1, TIGIT, and LAG-3, while it was negatively correlated with TNFRSF14. The CXCL2, CXCL12, and CX3CL1 genes of this signature were shown to be significantly expressed in monocytes and cancer cells, according to scRNA-seq analysis. Furthermore, the high expression of CD47 in cancer cells suggested us that this could be a promising immune checkpoint. For patients who had high riskscore, we predicted 12 potential medications.Conclusion: Overall, our findings show that a putative 7-chemokine-gene signature might predict a patient’s prognosis for ccRCC and reflect the disease’s complicated immunological environment. Additionally, it offers suggestions on how to treat ccRCC using precision treatment and focused risk assessment.
Biogenesis aberration: One of the mechanisms of thrombocytopenia in COVID-19
Authors: Shan Cuiting , Yu Feng , Deng Xuemei , Ni Li , Luo Xuming , Li Jialin , Cai Si , Huang Mian , Wang Xiongbiao 
Published: March 2023

Background: The pathogenesis of COVID-19, including thrombocytopenia, has not been fully clarified. The lungs are a major organ of platelet production and thrombocytopenia induced by severe COVID-19 was proposed.Methods: the change of platelet level was analysed with clinical parameters in 95 hospitalized COVID-19 patients in Wuhan Third Hospital. The production of platelets in the lungs was explored in an ARDS rat model.Results: The level of platelets was negatively correlated with disease severity and was recovered with disease improvement. The non-survivors were accompanied by lower levels of platelet. The odds ratio (OR) of the valley level of the platelet count (PLTlow) was greater than 1, suggesting that PLTlow could be a death exposure factor. The platelet/lymphocyte ratio (PLR) was positively associated with severity of COVID-19, and the platelet/lymphocyte ratio threshold of 248.5 was best correlated with death risk (sensitivity 0.641 and specificity 0.815). To demonstrate the possible biogenesis aberration of platelet in lungs, an LPS-induced ARDS rat model was applied. Lower level of platelet in peripheral and less production of platelet from lungs in ARDS were demonstrated. Though megakaryocyte (MK) number in ARDS lungs is higher than controls, the immature platelet fraction (IPF) in postpulmonary blood is still at the same level as prepulmonary in ARDS rat, indicating that ARDS rats generated fewer platelets in lungs.Conclusion: Our data suggested that COVID-19-induced severe lung inflammation may impair platelet production in the lung. Thrombocytopenia may be mainly caused by platelet consumption for multiorgan thrombosis; however, biogenesis aberration of platelet in the lung induced by diffuse interstitial pulmonary damage cannot be ruled out.
Metabolic profiling and gene expression analysis reveal the quality deterioration of postharvest toon buds between two different storage temperatures
Authors: Zhao Hu , Shen Cheng , Hao Qingping , Fan Mingqin , Liu Xiaoli , Wang Juan 
Published: March 2023

Toon buds, a popular woody vegetable, contain large amounts of nutrients. However, toon buds have strong respiratory metabolism after harvest and are highly prone to decay, resulting in quality deterioration. Low temperature can effectively inhibit postharvest senescence of toon buds. GC-TOF-MS combined with quantitative real-time PCR was used to elucidate the toon bud deterioration mechanism after harvest by analyzing the difference in the relative contents of primary metabolites and their derivatives, and the expression of key genes associated with metabolic pathways in toon buds between low temperature and room temperature storages for 72 h. Results showed that the ethylene synthesis in toon buds accelerated under room temperature storage, along with significant changes in the primary metabolic pathway. The catabolism of amino acids, fatty acids, and cell membrane phospholipids was accelerated, and the gluconeogenesis synthesis was strengthened. Moreover, the sucrose synthesis was increased, the glycolysis and TCA cycle were broken down, and the pentose phosphate pathway was vigorous. As metabolic intermediates, organic acids were considerably accumulated. Moreover, varieties of toxic compounds were produced in parallel with the activation of aromatic compounds. This work provided a comprehensive understanding of the metabolic regulation, thereby revealing how low and room temperatures differentially influenced the quality deterioration of postharvest toon buds.
The associations between body dissatisfaction, exercise intensity, sleep quality, and depression in university students in southern China
Authors: Hao Ming , Liu Xuesheng , Wang Ying , Wu Qingfeng , Yan Wenjing , Hao Yanbin 
Published: March 2023

BackgroundIn recent years, depression in early adulthood has become an urgent global public health concern. The university years mark a transitional period from adolescence to adulthood. Young people are required to face academic and life pressures independently, which increases the risk of mental health problems in university.PurposeThe main goal of the current study was to explore the sex differences in depression, body dissatisfaction, sleep quality, and exercise intensity among university students in southern China and to analyze the factors affecting the level of depression among university students.MethodsIn total, 1,258 university students aged 18–23 years were recruited for this study. All participants completed anthropometric measurements, the Self-rating Depression Scale, Physical Activity Rating Scale, and Pittsburgh Sleep Quality Index. Body dissatisfaction levels were measured using sex-appropriate silhouettes.ResultsCompared with young women, young men had higher exercise intensity and sleep quality, whereas young women’s body dissatisfaction and depression levels were significantly higher than those of young men. Sleep quality score (β = 0.34, p &lt; 0.01), sex (β = 0.15, p &lt; 0.01), physical activity score (β = −0.14, p &lt; 0.01), and body dissatisfaction (β = 0.14, p &lt; 0.01) were significant predictive factors of the Self-rating Depression Scale score.ConclusionLow levels of physical dissatisfaction have a positive effect on depression, and high levels of physical activity and quality sleep can also improve depressive symptoms. At the same time, increasing body satisfaction has the effect of increasing physical activity and improving sleep quality. Therefore, there is great potential to prevent and ameliorate depression by reducing body dissatisfaction.
Cancer literacy among Jordanian colorectal cancer survivors and informal carers: Qualitative explorations
Authors: Melhem Samar J. , Nabhani-Gebara Shereen , Kayyali Reem 
Published: March 2023

IntroductionCancer patients face a variety of challenges in understanding their diagnosis and treatment options. Making informed decisions requires health literacy. There is scant research on how colorectal cancer (CRC) survivors and their caregivers engage with healthcare systems and obtain cancer-related knowledge to maintain proper health literacy, which is crucial for enhancing their outcomes.Materials and methodsIn-depth semi-structured interviews (IDIs) with CRC survivors (n = 15) and online focus groups (FG) with informal caregivers (ICs) were held in Amman between Jan-June 2020. In-depth interviews were conducted using semi-structured interview protocol that addressed the healthcare experience of CRC cancer survivors. FGs evaluated ICs' perspectives of e-health for cancer care support. IDIs and FGs were done in the local Jordanian Arabic dialect, which was then translated into English. Transcribed audio-recordings were thematically coded and framework analysis was used.ResultsThe findings are organized around a central concept of “exploring the level of literacy and its impact.” From the overarching theme, three themes and subthemes emerged, including: (1) The current state of counseling and information provision, (2) The impact of lack of information, awareness, and literacy and (3) The health system's influence on literacy.ConclusionsPoor cancer literacy hinders patients throughout their cancer journey. Empowering cancer patients is crucial for a more timely and positive patient experience. Increased cancer literacy together with the creation of health-literate organizations and systems have the potential to improve patients' treatment throughout the continuum of care.
A radiomics approach to the diagnosis of femoroacetabular impingement
Authors: Montin Eros , Kijowski Richard , Youm Thomas , Lattanzi Riccardo 
Published: March 2023

IntroductionFemoroacetabular Impingement (FAI) is a hip pathology characterized by impingement of the femoral head-neck junction against the acetabular rim, due to abnormalities in bone morphology. FAI is normally diagnosed by manual evaluation of morphologic features on magnetic resonance imaging (MRI). In this study, we assess, for the first time, the feasibility of using radiomics to detect FAI by automatically extracting quantitative features from images.Material and methods17 patients diagnosed with monolateral FAI underwent pre-surgical MR imaging, including a 3D Dixon sequence of the pelvis. An expert radiologist drew regions of interest on the water-only Dixon images outlining femur and acetabulum in both impingement (IJ) and healthy joints (HJ). 182 radiomic features were extracted for each hip. The dataset numerosity was increased by 60 times with an ad-hoc data augmentation tool. Features were subdivided by type and region in 24 subsets. For each, a univariate ANOVA F-value analysis was applied to find the 5 features most correlated with IJ based on p-value, for a total of 48 subsets. For each subset, a K-nearest neighbor model was trained to differentiate between IJ and HJ using the values of the radiomic features in the subset as input. The training was repeated 100 times, randomly subdividing the data with 75%/25% training/testing.ResultsThe texture-based gray level features yielded the highest prediction max accuracy (0.972) with the smallest subset of features. This suggests that the gray image values are more homogeneously distributed in the HJ in comparison to IJ, which could be due to stress-related inflammation resulting from impingement.ConclusionsWe showed that radiomics can automatically distinguish IJ from HJ using water-only Dixon MRI. To our knowledge, this is the first application of radiomics for FAI diagnosis. We reported an accuracy greater than 97%, which is higher than the 90% accuracy for detecting FAI reported for standard diagnostic tests (90%). Our proposed radiomic analysis could be combined with methods for automated joint segmentation to rapidly identify patients with FAI, avoiding time-consuming radiological measurements of bone morphology.
An influencer pathway framework for sustainable tourism in SIDS ecotourism hotspots: A case of Aripo ecosystems, Trinidad
Authors: Wuddivira Mark N. , De Caires Sunshine A. , Joseph Jeanelle , Atwell Melissa A. , Lewis-Cameron Acolla 
Published: March 2023

IntroductionEcotourism hotspots in small island developing states (SIDS) are affected by unsustainable practices characterized by a lack of coordination, management inadequacies, and poor enforcement of policies and regulations. Consequently, depletion of natural resources and reduction in ecosystem value occur, with the undermining of the contribution of tourism to SIDS economies. An ecotourism system that ensures sustainable ecological integrity, economic viability, and social awareness is therefore critical in SIDS.MethodsWe developed an influencer ecotourism pathway framework (IPF) using the Aripo ecosystem as a case study of an ecotourism hotspot by focusing on influencers within a SIDS system to improve collaboration toward the common goal of ecosystem sustainability. The framework was created to reflect the ecosystem attributes and services found in Aripo, the influencers that both negatively and positively impact the environment, possible solutions specific to addressing these negative impacts, and the ecotourism goals of the area.Results and discussionThe framework was used to characterize the natural capital of Aripo in relation to the three (3) main ecosystems: forest, savanna, and man-made Aripo village. The influencer ecotourism framework provides a practical model to be applied for sustainable ecotourism management efforts in tropical small island regions as it identifies ecotourism attributes and ecosystem services, linking them to the potential impacts of influencers on the environment. It also provides useful insights to various influencers about their role in sustainable ecotourism that conserves the natural capital of the destination community while improving socioeconomic conditions.
CvAMoS—Event Abstraction Using Contextual Information
Authors: Di Federico Gemma , Burattin Andrea 
Published: March 2023

Process mining analyzes events that are logged during the execution of a process, with the aim of gathering useful information and knowledge. Process discovery algorithms derive process models that represent these processes. The level of abstraction at which the process model is represented is reflected in the granularity of the event log. When a process is captured by the usage of sensor systems, process activities are recorded at the sensor-level in the form of sensor readings, and are therefore too fine-grained and non-explanatory. To increase the understandability of the process model, events need to be abstracted into higher-level activities that provide a more meaningful representation of the process. The abstraction becomes more relevant and challenging when the process involves human behavior, as the flexible nature of human actions can make it harder to identify and abstract meaningful activities. This paper proposes CvAMoS, a trace-based approach for event abstraction, which focuses on identifying motifs while taking context into account. A motif is a recurring sequence of events that represents an activity that took place under specific circumstances depicted by the context. Context information is logged in the event log in the form of environmental sensor readings (e.g., the temperature and light sensors). The presented algorithm uses a distance function to deal with the variability in the execution of activities. The result is a set of meaningful and interpretable motifs. The algorithm has been tested on both synthetic and real datasets, and compared to the state of the art. CvAMoS is implemented as a Java application and the code is freely available.
AĞAÇERİ KAVMİNİN GEÇMİŞTEN BUGÜNE UZANAN TARİHİ VE TAHTACI CEMAATİYLE BAĞLANTISI
Authors: TAŞ Kibar 
Published: March 2023

Bu çalışmada, Ağaçeri ve Tahtacı Türkmenlerinin geçmişten bugüne uzanan tarihleri hakkında, hem kaynaklar hem de arşiv belgelerine dayanılarak çeşitli bilgiler verilmiş ve ikisi arasında nasıl bir bağ olabileceği tartışılmıştır.
Ağaçeri Türkmenlerinin ismi Anadolu’da ilk olarak, 13. asrın ikinci yarısına ait yazılı kaynaklarda yer aldı. Bu asır, Anadolu Selçuklu Devleti’nin zayıflamaya başladığı, Moğolların Anadolu’da hakimiyet kurduğu bir dönemdir. Yine bu dönemde, Türkmen-Alevilerin yoğunlukta olduğu çok sayıda kavim Türkistan ve Horasan’dan gelerek Anadolu’yu yurt tuttu. Böyle bir ortamda, daha tanınan Oğuz boyları ile birlikte, Ağaçerilerden bahsedilmesi oldukça önemlidir. Çağdaşları tarihçilerin eserlerinde bu kavme yer vermesi, hem sayıca çok olmaları, hem de savaşçı karakterleri yüzündendir. Ancak bu özelliklerine rağmen, sonraki asırlarda Anadolu’da çok az kaynak ve arşiv belgesinde yer aldılar ve bunun başlıca sebebi de, çoğunluğunun Karakoyunlu Devleti ile birlikte İran’a göç etmiş olmasıdır. Nitekim bugün dahi İran’da azımsanmayacak oranda Ağaçeriler yaşamakta, ayrıca bu isimde yerleşim yeri de bulunmaktadır.
Bugün, geçmişteki Ağaçerilerin devamı olarak Tahtacı cemaati görülmektedir. Bunun nedeni, isimlerinin taşıdığı anlamın yakın olması, başlangıçta aynı yerlerde yurt tutmuş olmaları ve Alevi inancına sahip olmalarıdır. Fakat Tahtacılar arasında tek bir cemaat yoktur. Onlar çeşitli Türkmen Alevi boyların biraraya gelmelerinden oluştular.
Metodologias para gestão documental em instituições de ensino superior
Authors: Santos Rosaria Ferreira Otoni dos , Aganette Elisângela Cristina 
Published: March 2023

A gestão documental constitui um conjunto de procedimentos referente à tramitação de documentos visando à eliminação ou guarda permanente, de modo que as instituições identifiquem o fluxo documental e fortaleçam a tomada de decisão para melhorar o desempenho dos seus processos. Neste contexto, objetiva-se verificar a existência de metodologias para gestão documental em Instituições de Ensino Superior brasileiras, com o propósito de evidenciar o cenário, por meio da literatura publicada. Mediante aplicação da revisão sistemática da literatura, realizaram-se buscas na base de dados da Library & Information Science Abstracts, cujos resultados preliminares evidenciaram a existência de metodologias voltadas à construção de instrumentos de tratamento da informação, ao diagnóstico institucional e ao uso dos sistemas informatizados, embora elas sejam incipientes. Portanto, recomenda-se ampliar os estudos desta pesquisa, a fim de aprofundar as consultas e análises propostas, além da realização de ajustes no protocolo de revisão.
A gestão do conhecimento no contexto do teletrabalho em função do isolamento social
Authors: Teixeira Rômulo de Barros , Barbosa Ricardo Rodrigues 
Published: March 2023

A pandemia causada pelo COVID-19 mudou a rotina de pessoas e empresas e fez com que o uso das tecnologias de informação e comunicação se tornassem fundamentais para o andamento de boa parte das atividades profissionais, pessoais e educacionais. As limitações do encontro entre as pessoas, um efetivo convívio social e a troca de experiências foi muito prejudicada. Diante desse cenário, foi realizado o estudo com base em uma revisão de literatura sobre Gestão do Conhecimento (GC) no contexto do Teletrabalho. Os achados demonstram que os princípios e instrumentos relacionados com a GC podem ser uma possível solução para o compartilhamento, o registro, a utilização e a disseminação do conhecimento gerado pelos colaboradores.
On acoustic guided wave propagation in reinforced concretes and characterization of interface bonding damages
Authors: Zhang Mingwei , Zeng Zhoumo , Li Jian , Chen Shili , Liu Yang 
Published: March 2023

Abstract
As a possible method for structural health monitoring, guided waves are excellent for hidden damage diagnosis due to their long propagation distance and high damage sensitivity. The multimodal and dispersion phenomena are the primary challenges in the use of guided wave technology for engineering applications. Currently, plate, thin-walled tube, and rod structures—where multimodality and dispersion are comparatively mild and simple to control—remain the major applications of guided wave technology. For more complicated civil engineering structures, severe multimodal and dispersion phenomena cause more difficult issues. The present work began with the study of round-faced reinforced concrete. The waveguide propagation characteristics are computationally analyzed with the assistance of theoretical calculation methods and sweeping frequency simulation experiments. These analytical tools are then creatively applied to threaded reinforced concrete, and the dispersion characteristics of this complex, axially periodically varying waveguide are successfully analyzed. The phenomenon of frequency band pass/stop is also discussed. In addition, this research provides ideas for nondestructive testing and inverse imaging in this field by means of deep learning of the interface debonding defect characteristics of reinforced concrete with the help of convolutional neural networks. This work can be applied not only to various complex reinforced concrete structures but can also be extended to waveguide propagation analysis and defect size data inversion in various complex periodic structures.
Evaluation of blocking temperature and its distribution for L10-type FePt granular films
Authors: Isurugi Daiki , Saito Takashi , Kaneko Shun , Tham Kim Kong , Ogawa Tomoyuki , Saito Shin 
Published: March 2023

Abstract
The blocking temperature (T
B) and blocking temperature distribution (ΔT
B) of magnetic grains were evaluated for L10-type FePt granular films with various grain boundary materials (GBMs). T
B and ΔT
B were measured from remanent magnetization. The relationship between the degree of order and Curie temperature (T
C) for the L10-type FePt phase was separately evaluated using alloy films. According to actual measurements, the obtained mean T
B, mean T
B/T
C and ΔT
B for granular films were 620 K, 0.83 K, and 200 K, respectively, for SnO GBM film and 450 K, 0.61 K, and 260 K, respectively, for TiO2 GBM film. Based on these values, mean T
B, mean T
B/T
C, and ΔT
B were calculated assuming that τ = 2 × 10−7 s, which is the relaxation time, corresponds to the HAMR writing time. These were 737 K, 0.98 K, and 24 K, respectively, for SnO GBM film and 685 K, 0.93 K, and 72 K, respectively, for TiO2 GBM film. These results for granular films can be useful for designing a hard disk drive with HAMR.