bluuebunny/crossref_metadata_2025_split huggingface dataset:
Обсуждение идеи создания Института демографии АН СССР в 1944 г.
Authors: Богоявленский Дмитрий Дмитриевич , Захаров Сергей Владимирович 
Published: January 2025

Впервые публикуется архивный документ – записка, подготовленная в 1944 г. известным статистиком и демографом А.И. Гозуловым в адрес Президиума Академии наук СССР с предложением организовать в системе академических учреждений специализированный институт демографии. К записке прилагается детально разработанная программа направлений научной деятельности, административная структура и штатное расписание будущего института. К этому моменту в СССР не было ни одного научно-исследовательского центра демографической направленности после закрытия Демографического института АН СССР в Ленинграде (в 1934 г.) и Института демографии АН УССР в Киеве (в 1938). Идея создания института демографии получила поддержку видных ученых того времени – статистиков, экономистов и демографов. Однако руководитель Центрального статистического управления В.Н. Старовский идею не поддержал, аргументируя тем, что передача исследователям для изучения статистической информации о демографических процессах в стране нецелесообразна.
Evaluation of utilization of amplified blastocoel fluid DNA gel electrophoresis band intensity as an additional minimally invasive approach in embryo selection: A cross-sectional study
Authors: Khajehoseini Fattaneh , Noormohammadi Zahra , Eftekhari-Yazdi Poopak , Gourabi Hamid , Pazhoomand Reza , Hosseinishenatal Shirzad , Bazrgar Masood 
Published: January 2025

Background: Embryo selection for transfer is critical in assisted reproduction. The presence of DNA in the blastocoel cavity of human blastocysts is assumed to be a consequence of common preimplantation chromosomal abnormalities.
Objective: This study examined the relationship between the amount of blastocoel fluid (BF) DNA and the band intensity of amplified BF-DNA in gel electrophoresis, considering the influence of ploidy status.
Materials and Methods: This cross-sectional study categorizes blastocysts into 2 groups based on the array comparative genomic hybridization results by trophectoderm biopsy -the euploid and aneuploid group. After morphological scoring, a biopsy of BF was performed for whole genome amplification, followed by an assessment of band intensity and BF-DNA quantification. The relationship between BF-DNA levels, band intensity, and ploidy status were analyzed.
Results: The level of BF-DNA was higher in the aneuploid group compared to the euploid group, but the difference was not statistically significant (p = 0.2). We observed that the band intensity was affected by the ploidy status of the embryos, although this difference was not statistically significant (p = 0.059). Notably, electrophoresis band of all embryos with chromosomal loss was strong. No correlation was observed between embryo morphology and chromosomal ploidy (p = 0.8).
Conclusion: Our findings indicate that BF-DNA band intensity on agarose gel is not currently applicable for preimplantation embryo selection. It seems that embryos with chromosomal loss are more prone to DNA release to BF. The disrelation between embryo morphology and ploidy status represents the necessity of minimally invasive embryo screening methods based on ploidy status.
The association between the amount of fetal fraction in cell-free DNA testing and adverse pregnancy outcomes: A cohort study
Authors: Aryavand Maryam , Nurzadeh Maryam , Ghaemi Marjan , Eskandari Delfan Sina , Marsoosi Vajiheh 
Published: January 2025

Background: Noninvasive perinatal testing is a new method of screening for aneuploidy called cell-free DNA (cfDNA). Fetal fraction (FF) plays a crucial role in assessing the reliability of aneuploidy detection through noninvasive perinatal testing.
Objective: We aimed to investigate the association between the amount of FF in cfDNA testing and adverse pregnancy outcomes.
Materials and Methods: This cohort study was conducted on 619 singleton pregnant women who were candidates for cfDNA testing and were referred to the perinatology clinics of Shariati hospital and Arash Women’s hospital, both affiliated with Tehran University of Medical Sciences, Tehran, Iran from March 2019 to June 2020. The FF was extracted from the cfDNA test results, and the participants were followed until delivery.
Results: A total of 619 singleton pregnant women with a mean ± SD age and FF of 34.4 ± 4.85 and 8.39 ± 3.95, respectively, participated in the study. A significant association between maternal age and FF was not found (p = 0.12). A lower FF was associated with a rise in the incidence of gestational diabetes mellitus (p = 0.02) and a higher FF was associated with a rise in the incidence of fetal growth restriction (p < 0.001). However, high or low FF was not associated with pre-eclampsia, premature rupture of membranes, birth weight, or delivery time. No significant association was found between FF and multiple of the median of pregnancy-associated plasma protein-A and free β-human chorionic gonadotropin.
Conclusion: The amount of FF may be considered a predictor of certain adverse pregnancy outcomes. Therefore, maternity care should be performed more carefully for women with high or low FF.
Exploring Factors Influencing Physical Activity Behaviours among Middle-Aged Adults in Johor Bahru, Malaysia: A Mixed-Methods Approach
Authors: Kaur Jasveen , Nambiar Nisha 
Published: January 2025

Abstract

This study aims to explore the factors influencing physical activity behaviours among middle-aged individuals in Johor Bahru, Malaysia, through a mixed-methods approach. Qualitative data were collected using structured surveys administered to a representative sample of 384 participants. Focus group discussions (FGDs) were conducted to explore participants' experiences and attitudes towards physical activity. Thematic analysis revealed that family support and community resources were significant facilitators of physical activity in this demographic. Regression analysis revealed age, socioeconomic status, and family support were significant predictors for physical activity levels. The study demonstrates that addressing specific barriers, such as work-related time constraints and lack of motivation, while leveraging facilitators like family support or community resources, can enhance physical activity and improve health outcomes in this population. Tailoring interventions to address the identified barriers and promote the facilitators can lead to more effective strategies for increasing physical activity, ultimately contributing to better public health outcomes.
Genome-wide identification of silencers and their regulatory mechanism in gene transcription in Arabidopsis
Authors: Chen Mao-Sheng , Yan Xiaohao , Niu Longjian , Li Xinxin , Fu Qiantang , Tang Mingyong , Wei Chi , Hou Chunhui 
Published: January 2025

Abstract

Gene transcription regulation is essential for eukaryotic development. Despite the considerable advances has been made in cis-regulatory elements, the roles of silencers in gene transcription, particularly in plants, remain largely elusive. Here, we employed a method called repressive self-transcribing active regulatory region sequencing (REST-seq) to systematically identify silencers across the Arabidopsis genome, modified from the STARR-seq for enhancer identification. In all, 13,032 silencers were identified from two distinct developmental stages of leaves, of which approximately 69.3% (74.6%) are located in the promoter and 3′–untranslated region (3’–UTR) regions. Genes overlapping with silencers exhibited higher expression levels than those without silencers, and the occurrence of silencers in the TES regions was positively correlated with the expression levels of proximal genes. Almost all acetylation modifications, H3K4me3, chromatin accessibility sites, as well as numerous transcription factor binding sites (TFBSs), were significantly enriched in the flanking regions of silencers, whereas they were deleted in the body regions. Numerous histone modifications and TFBSs have opposite distributional characteristics around silencers and enhancers, suggesting that they play opposing roles in controlling gene transcription. In static cases, silencers and enhancers might directly participate in proximal gene transcription rather than through distal chromatin contact loops. In dynamic cases, however, the enrichment patterns of silencers and enhancers in differentially expressed genes (DEGs) are reversed, and they govern DEG transcription through both proximal involvement and distal chromatin contact loops. Silencers and enhancers cooperatively regulate gene transcription to maintain an optimal transcript abundance of targeted genes during the development of Arabidopsis leaves. In addition, silencer activity was validated using the transgenic Arabidopsis, and several silencers displayed evident enhancer activity and strong tissue-specificity, implying that these elements may exhibit bifunctional activity in different tissues and spatiotemporal conditions. This study provided a reliable method for genome-wide silencer identification and demonstrated the roles of silencers and enhancers in the regulation of gene transcription, which will facilitate the elucidation of the regulatory mechanisms governing gene transcription in Arabidopsis.
Effect of perioperative probiotic intervention on postoperative cognitive dysfunction in elderly patients: A randomized double- blinded and placebo-controlled trial
Authors: gao sunan , dai hongyu , hao qian , song jiale , ji kang , xu hongwie , chen gang , lu jian 
Published: January 2025

Abstract

Background: Postoperative cognitive dysfunction (POCD) may last for days, months or even years, leading to prolonged hospitalization and increased costs, increased mortality, and poor quality of life. Although POCD is an important clinical problem, its prevention, treatment strategies and effects are still limited.
Objective: This study aims to investigate the preventive effect of perioperative probiotic intervention on POCD in elderly patients, and further explore the mechanism of probiotics in improving postoperative cognitive function.
Methods: After obtaining ethical approval and written informed consent, 190 patients aged 65 years or older scheduled for elective lower-extremity orthopedic surgery were enrolled in this randomized, double-blind trial. Enrolled patients were randomized to probiotic or control groups receiving either probiotics or placebo (210mg×4/dose, 2 times/day) from 1 day before surgery to 5 days after surgery. The primary outcome was the cognitive function assessed by Mini-mental State Examination (MMSE) on admission, the first day, the third day and the seventh day after surgery. The secondary outcomes included perioperative changes in plasma IL-1b, IL-6 and BDNF, postoperative pain intensity, perioperative activities of daily living (ADL), faecal microbiota composition and changes of intestinal metabolites
Results: The incidence of POCD in the probiotic group was significantly lower than in the control group (6 of 90 patients [6.7%] vs. 16 of 93 patients [17.2%], P=0.028). In addition, the plasma levels of proinflammatory cytokines IL-1β and IL-6 were significantly lower and BDNF levels were significantly higher in the probiotic group than in the control group 1-2 days after surgery (U=173.0, P<0.01; U=139.0, P<0.01; U=207.0, P<0.01).
Conclusion: Perioperative probiotic intervention can reduce the incidence of POCD in elderly patients, which may improve cognitive function by inhibiting inflammatory response after anesthesia and surgery, andaltering the composition of the postoperative gut microbiota and intestinal metabolites.
Microemulsion Depressurization and Increasing Injection Technology for Tight Reservoirs
Authors: Wu Yuhang , Wang Li , He Siqi , Gu Yujie , Chen Hong , Huang Wei 
Published: January 2025

Abstract

Although some microcracks or large cracks occur during fracturing in the tight reservoirs, the average permeability and porosity of the reservoir matrix are relatively low: 0.76×10− 3 µm2 and 11.5%, respectively. These values are typical of a typical low-permeability tight reservoir. Currently, the water injection pressure during the development of reservoir water injection is high and exceeds the reopening pressure of a crack. The pressure is close to the formation fracture pressure, which minimizes the phenomenon of water breakthrough and water injection efficiency. The reservoir matrix is substantially under injection. Therefore, a method to reduce the injection pressure and improve the matrix injection capacity is urgently needed. According to the features of tight reservoirs and crude oil, three kinds of microemulsion are screened: 13% AP6 + 4% polyoxyvinyl ether surfactant + 4% sodium petroleum sulfonate + 4% lower alcohol + 6% oil phase + 69% salt solution and 0.5% anti-temperature agent. The maximum soluble capacity of onsite oil is 14%. Microemulsion has excellent temperature resistance; if it is heated for 24 hours at 70°C, it does not break. Microemulsion also has excellent salt and anti-dilution performance. No turbidity occurs after the microemulsion and the formation water are mixed in any proportion for 24 hours. A core displacement experiment using microemulsion was performed in a lab. The results of the research indicate that the water injection pressure is reduced to a minimum of 40% when the injection concentration of the microemulsion is 1% and the injection slug is 5 PV.
OrganPipe: An automated tool to facilitate the assembly, annotation, and curation of mitochondrial and chloroplast genomes
Authors: Moreira-Oliveira† Renato R. , Silva† Bruno Marques , Molina Michele , Oliveira-Lima Marx , Leão Tiago Ferreira , Vasconcelos Santelmo , Nunes Gisele Lopes 
Published: January 2025

Abstract

Analyzing organellar genomes (plastomes and mitogenomes) is important for understanding evolution, cellular function, and genetic diversity. Their stable mutation rates and inheritance patterns make them valuable for phylogenetic studies and taxonomic delimitation approaches. Assembling organellar genomes is considerably more straightforward than nuclear genomes due to their smaller size and simpler structure. To that end, existing tools like NOVOPlasty, GetOrganelle, and MitoHifi can handle different sequencing data types but have limitations, such as the reliance on single k-mers or reference genomes, which leads to suboptimal results and requires manual adjustments of parameters. OrganPipe, a newly developed pipeline, overcomes these challenges by allowing iterative assembly and annotation using multiple seeds and k-mers combinations. To demonstrate its capabilities, OrganPipe was used to assemble and annotate the first mitogenomes of two invertebrate species and the plastomes of two plant species, successfully circularizing and annotating the genomes with high accuracy, besides identifying key genomic features and correcting errors missed by other tools. Accessible to beginners and non-bioinformaticians, OrganPipe empowers diverse users to perform high-quality organelle genome analyses, supporting comprehensive exploration and efficient curation. This versatile tool advances large-scale genomic studies with its user-friendly and efficient design and is accessible at https://github.com/itvgenomics/OrganPipe.

†joint first authors
A learning-driven algorithm for maintenance team and UAV collaboration in restoring power network
Authors: Pan Tiejun , Zheng Leina , Xu Ying , Zhang Xuefeng , Zhong Caiming , Wang Zhang 
Published: January 2025

Abstract

Power networks are highly vulnerable to disruptions caused by natural and man-made disasters, necessitating prompt restoration of damaged power supply. This research addresses the challenge of efficiently restoring large-scale power networks, which often involve numerous unknown or uninspected faulty nodes. Leveraging advancements in unmanned aerial vehicles (UAVs) technology, this study facilitates the inspection of these nodes and subsequent manual maintenance. However, coordinating maintenance teams and UAVs is complex due to the intricate network structure and scheduling correlations. We propose a learning-driven (LD) algorithm to enhance human-UAV collaboration for effective power network restoration. The algorithm includes an initialization method to generate promising initial solutions, followed by the use of search operators as basic action elements and a learning engine to guide search directions based on state assessments. Comprehensive experiments validate the algorithm’s effectiveness in improving the restoration process.
Structural and Geophysical Modeling in an area with non-outcropping Copper Sulphide Deposits, Minas Do Seival Region, Sul-Riograndense Shield, Southern Brazil
Authors: Araujo Ana Flávia , Moreira César Augusto , Alves Luiza Lima , Ilha Lenon Melo , Kumaira Sissa , Masquelin Henri , Duz Beatriz Guzzo 
Published: January 2025

Abstract

This paper is based on the use of indirect investigation methods using geophysics as a tool for the search for non-outcropping deposits. The integration of the geophysical methods of DC Resistivity and Induced Polarization added to the analysis of structural data is adopted in the region of Minas do Seival, in the extreme south of Brazil, in an area with no signs of surface mineralization. The region is located in the context of the Sul-Riograndense Shield, with andesites, dacites and latites occur locally, in addition tuffs, lapilli tuffs and breccia tuffs, gathered in the Hilário Formation (Neoproterozoic). The structural survey was carried out at the Barita Mine, in outcropping lapilli tuffs where brecciation, argilization and carbonation were recognized in mineralized zones, with malachite and azurite. Next, 6 electrical tomography lines with 420m of length. The combined analysis of the 2D and 3D models allows the recognition of potentially mineralized zones characterized by high chargeability. The results indicate the existence of a deposit from 30m deep with a tendency to connect the mines, partly related to silicification processes (high chargeability + high resistivity) and partly related to argilization and propylitization (high chargeability + low resistivity), structurally controlled.
The entanglement amid the multi-national geopolitical risk: Evidence from the dynamic network analysis
Authors: Cui Mingwei , Cheng Ralph , Ning Tao , Jin Ming , Zhu Gehui 
Published: January 2025

Abstract

The entanglement among multinational geopolitical risks is crucial for understanding the complexities and interdependencies of global politics and economies and among multinational geopolitical risks (GRP) offers valuable insights into the complexities and interdependencies of global affairs. It enhances our understanding of transmission channels, systemic vulnerabilities, power dynamics, contagion effects, risk management strategies and international legal rules. geographical connections play a significant role in influencing how countries' geopolitical risks are related to each other. However, simply being geographically close is not enough to explain these relationships. Various factors like international trade, historical correlations,legal tradition and military alliances also contribute to these connections. The passage highlights that entities such as governments, institutional investors, and multinational corporations are highly concerned about the impact of geopolitical risks. To aid them in managing the effects of geopolitical events, the constructed GPR network serves as a useful point of reference.
The moderating role of depressive symptoms in the relationship between sleep duration and psychological resilience among Chinese old adults with multiple chronic conditions
Authors: Gao Lunan , Zhao Sen 
Published: January 2025

Abstract

Objective: Many researches showed that psychological resilience was associated with sleep duration and depressive symptoms among the elderly. But the mechanisms underlying the relationship among old adults with multiple chronic conditions (MCC) remain unclear. This cross-sectional study aimed to explore the relationship among sleep duration, depression and psychological resilience among old adults with MCC in China and further explore the mediating role of depression between sleep duration and psychological resilience.
Methods: This study included 2339 older adults with MCC from the Chinese Longitudinal Healthy Longevity Survey (CLHLS). Participants completed questionnaires that assessed sleep duration, depression and psychological resilience. We used SPSS Process 4.0 to investigate the relationship between sleep duration, depression and psychological resilience, adjusting for a range of potential covariates and a bootstrapping sample test to examine the potential moderating role of psychological resilience in these relationships.
Results: Mean psychological resilience score was (15.60 ± 2.33) (range: 5-25). Sleep duration (r = 0.129, P < 0.01) and depressive symptoms (r = -0.547, P < 0.01) were significantly related with psychological resilience. Mediation analysis showed that depressive symptoms played a partially mediating role between sleep duration and psychological resilience, with the indirect effect of 0.114 (95% CI: 0.037-0.194), accounting for 28.29% of the variance in the relationship between sleep duration and psychological resilience.
Conclusions: Impaired sleep duration appears to accelerate depression in the elderly with MCC. Sleep duration and psychological resilience were found to be significantly positively correlated among Chinese old adults with MCC. This association was partially mediated by depressive symptoms.
Investigating the role of opium consumption in the severity, and outcome of COVID-19
Authors: Amin Fatemeh , Ostadebrahimi Hamid , Parvaz Najmeh , Eslami Hadi , Maleki Haniyeh , Kazempour Somayeh 
Published: January 2025

Abstract

Background
The coronavirus disease 2019 (COVID-19) pandemic has become a major challenge to healthcare systems and public health policies globally. Some people are more susceptible to coronavirus. The impact of opium use as a risk factor for COVID-19 is yet uncertain. This study investigate the effect of opium consumption on the severity of COVID-19, and its adverse consequences in opium users compared to the general population.
Methods
This study included 2945 COVID-19 patients that had been referred to health care centers affiliated to Rafsanjan University of Medical Sciences. The personal, and clinical data including clinical presentation, the severity of symptoms, and outcome were collected. Then, the COVID-19 severity, and outcome between opium users and opium non-users were compared.
Results
The rate of opium users was 5.13% that 87.42% of them recovered while this percentage for non-users was 86.07% (p ꞊ 0.641). In the crude regression model, the odds of the death due to COVID-19 is 0.88 (95%CI 0.54 to 1.45). The odds of the severity of COVID-19 is almost half among opium users compared with non-users (odds ratio (OR): 0.48, 95%CI 0.34 to 0.66). This association persisted after adjustment for confounders. We observed that with adjustment for confounders, opium consumption decreases the severity of COVID-19 but has no significant effect on mortality.
Conclusion
There was a negative association between opium use with the severity, and death due to COVID-19. However, it is suggested more laboratory and clinical trial studies using pharmaceutical morphine products, the main component of opium.