bluuebunny/crossref_metadata_2025_split huggingface dataset:
Single-Cell Sequencing Analysis Fibrosis Provides Insights into the Pathobiological Cell Types and Cytokines of Radiation-Induced Pulmonary Fibrosis
Authors: Sun Zhiyong , Lou Yutao , Hu Xiaoping , Song Feifeng , Zheng Xiaowei , Hu Ying , Ding Haiying , Zhang Yiwen , Huang Ping 
Published: January 2023

Abstract
Background
Radiotherapy is an essential treatment for chest cancer. Radiation-induced pulmonary fibrosis (RIPF) is an almost irreversible interstitial lung disease; however, its pathogenesis remains unclear.
Methods
We analyzed specific changes in cell populations and potential markers by using single-cell sequencing datasets from the Sequence Read Archive database, PERFORMED from control (0 Gy) and thoracic irradiated (20 Gy) mouse lungs at day 150 post-radiation. We performed IHC and ELISA on lung tissue and cells to validate the potential marker cytokines identified by the analysis on rat thoracic irradiated molds (30 Gy).
Results
Single-cell sequencing analysis showed changes in abundance across cell types and at the single-cell level, with B and T cells showing the most significant changes in abundance. And four cytokines, CCL5, ICAM1, PF4 and TNF, were significantly upregulated in lung tissues of RIPF rats and in cell supernatants after ionizing radiation.
Conclusion
Cytokines CCL5, ICAM1, PF4 and TNF may play essential roles in radiation pulmonary fibrosis. They are potential targets for the treatment of radiation pulmonary fibrosis.
Network-based Control of Epidemic via Flattening the Infection Curve: High-Clustered vs. Low-Clustered Social Networks
Authors: Doostmohammadian Mohammadreza , Rabiee Hamid R. 
Published: January 2023

Abstract
Recent studies in network science and control have shown a meaningful relationship between the epidemic processes (e.g., COVID-19 spread) and some network properties. This paper studies how such network properties, namely clustering coefficient and centrality measures (or node influence metrics), affect the spread of viruses and the growth of epidemics over scale-free networks. The results can be used to target individuals (the nodes in the network) to flatten the infection curve. This so-called flattening of the infection curve is to reduce the health service costs and burden to the authorities/governments. Our Monte-Carlo simulation results show that clustered networks are, in general, easier to flatten the infection curve, i.e., with the same connectivity and the same number of isolated individuals they result in more flattened curves. Moreover, distance-based centrality measures, which target the nodes based on their average network distance to other nodes (and not the node degrees), are better choices for targeting individuals for isolation/vaccination.
A randomized, double-blind, control trial study to compare clinical outcomes of users and nonusers of a walking support machine after total knee replacement surgery
Authors: Rattanasomboonchai Siripen , Watcharamaisakul sukasem , Sindhupakorn Bura 
Published: January 2023

Abstract

Background
Rehabilitation is one of the keys to success following total knee replacement (TKR). Many methods can be used to reduce knee forces during weight-bearing exercises.
Objectives
The purpose of this study is to assess the effectiveness of a walking support machine (Co-walk) in improving clinical outcomes in TKR patients.
Methods
62 TKR patients were equally and randomly divided into two groups: the control group (Non Co-walk) and the experimental group (Co-walk). Both groups followed a standard 45-minute rehabilitation program. The Co-walk received an additional 15-minute Co-walk session once a week for 6 weeks. Outcomes were measured at admission and at 2 weeks, 6 weeks, 3 months, and 6 months in TKR patients.
Results
Participants in the Co-walk group demonstrated significantly different scores on the TUG test (18.10 ± 6.45) and the WOMAC pain scale (13.29 ± 5.49) at 2 weeks, 6 weeks, and 3 months (p < 0.001). WOMAC and ROM were statistically significant in the Co-walk group (36.10 ± 13.78) at 2 weeks, 6 weeks, 3 months, and 6 months (p < 0.001). WOMAC stiffness scores were statistically significant in the Co-walk group (6.03 ± 3.62) at 2 weeks (p < 0.001). Postural control for patients in the Co-walk group showed significant improvement in position (Left 16[8.5(6.5–14.0)]and Right 11[10.0(3.0–24.0)]) at 2 weeks, 6 weeks, 3 months, and 6 months. The experimental group and control group showed no significant difference in LOS (p = 0.379).
Conclusion
Co-walk effectively improves outcomes during the early rehabilitation period. It may be better than physical therapy rehabilitation programs alone.
Smartphone-assisted training with education for patients with hip and/or knee osteoarthritis (SmArt-E): Study protocol for a multicentre pragmatic randomized controlled trial
Authors: Weber Franziska , Müller Carsten , Bahns Carolin , Kopkow Christian , Färber Francesca , Gellert Paul , Otte Ina , Vollmar Horst Christian , Brannath Werner , Diederich Freya , Kloep Stephan , Rothgang Heinz , Dieter Valerie , Krauß Inga , Kloek Corelien , Veenhof Cindy , Collisi Sandra , Repschläger Ute , Böbinger Hannes , Grüneberg Christian , Thiel Christian , Peschke Dirk 
Published: January 2023

Abstract
Introduction: Hip and knee osteoarthritis are associated with functional limitations, pain and restrictions in quality of life and the ability to work. Furthermore, with growing prevalence, osteoarthritis is increasingly causing (in)direct costs. Guidelines recommend exercise therapy and education as primary treatment strategies. Available options for treatment based on physical activity promotion and lifestyle change are often insufficiently provided and used. In addition, the quality of current exercise programmes often does not meet the changing care needs of older people with comorbidities and exercise adherence is a challenge beyond personal physiotherapy. The main objective of this study is to investigate the short- and long-term (cost-)effectiveness of the SmArt-E programme in people with hip and/or knee osteoarthritis in terms of pain and physical functioning compared to usual care.
Methods: This study is designed as a multicentre randomised controlled trial with a target sample size of 330 patients. The intervention is based on the e-Exercise intervention from the Netherlands, consists of a training and education programme and is conducted as a blended care intervention over twelve months. We use an app to support independent training and the development of self-management skills. The primary and secondary hypotheses are that participants in the SmArt-E intervention will have less pain (numerical rating scale) and better physical functioning (Hip Disability and Osteoarthritis Outcome Score, Knee Injury and Osteoarthritis Outcome Score) compared to participants in the usual care group after twelve and three months. Other secondary outcomes are based on domains of the Osteoarthritis Research Society International (OARSI). The study will be accompanied by a process evaluation.
Discussion: After a positive evaluation, SmArt-E can be offered in usual care, flexibly addressing different care situations. The desired sustainability and the support of the participants' behavioural change are initiated via the app through audio-visual contact with their physiotherapists. Furthermore, the app supports the repetition and consolidation of learned training and educational content. For people with osteoarthritis, the new form of care with proven effectiveness can lead to a reduction in underuse and misuse of care as well as contribute to a reduction in (in)direct costs.
Trial registration: German Clinical Trials Register, DRKS00028477. Registered on August 10, 2022.
A solution to a linear boundary value problem for an impulsive integro-differential equation
Authors: Mynbayeva Sandugash , Assanova Anar , Uteshova Rosa 
Published: January 2023

Abstract
This study deals with a boundary-value problem for a linear Fred-holm integro-differential equation subject to impulse effects at fixed time points. Solvability criteria are provided in terms of input data, without the use of a fundamental matrix and a resolvent. We also propose an algorithm to solve the problem under consideration, establish its convergence conditions, and provide a numerical version of the algorithm.
MSC Classification: 34A37; 34B37; 45J05; 45J99; 34K28
Sales-Dominance Relations And Disclosure Of Product Information
Authors: Woo Hee Yeul 
Published: January 2023

Abstract
In a framework allowing for both vertical and horizontal product differentiation, the seller persuades the consumer of unknown taste by sending verifiable product information. The standard unraveling argument does not extend well under horizontal differentiation mainly because it is indefinite how to rank seller types. By defining price-dependent sales-dominance relations over seller types, we provide a generalized unraveling argument that can be applied no matter how products are differentiated. We show that if a sales-dominant seller type exists at a price over some seller types, an outcome at which all and only these seller types pool at this price doss not emerge regardless of the prior. We argue that sales-dominance relation is complete at every price if and only if full disclosure is the unique outcome regardless of the prior. We find the condition under which a worst-case type is well-defined regardless of the prior for every observable deviation of the seller. Finally, we explore product information the consumer could receive when sales-dominance relations are incomplete.
Brazilian food biodiversity: a richness invisible on our plates
Authors: Gomes Sávio , Chaves Viviany , de Carvalho Aline , Silva Elenilma da , Neto Elias de Menezes , Moura Gabriela , Chaves Leonardo , Alves Rômulo , de Albuquerque Ulysses , Pereira Fillipe , Jacob Michelle 
Published: January 2023

Abstract
Food biodiversity is essential for improving nutrition and reducing hunger in populations worldwide. However, the relationship between food availability and food consumption in middle and low-income countries is still controversial. We used Brazil, one of the world's megabiodiverse countries, as a case study to investigate the magnitude of biodiversity consumption in the diet of the entire population of the country. Here we show that food biodiversity was consumed by 1.3% of the population, varying according to socioeconomic aspects, such as race, sex and income. The consumption of unconventional food plants is an indicator of the risk for socioeconomic vulnerability among historically oppressed groups.
Proficiency of some synthetic alginate derivatives for sequestration of Iodine-131 from radioactive liquid waste
Authors: Hassan Reham S. , Eldahab H. M.M. Abo , Shehata F. A. , El-Reefy S. A. 
Published: January 2023

Abstract

The current effort in environmental remediation is aimed at removing iodine-131 radionuclide from radioactive liquid waste produced by an Egyptian nuclear power plant using some synthesised alginate derivatives. Two different copolymers, namely sodium alginate poly (acrylic acid) (P1) and sodium alginate poly (acrylic acid-methacrylic acid) (P2), are prepared using gamma radiation. The ability of these polymers to remove 131I radionuclide as sorbents has been investigated. The synthesised polymers exhibit excellent adsorption performance for 131I ions, and the adsorption equilibrium requires only 30 min, which reveals that the sorption process is kinetically faster than most of the other materials reported previously. The removal percents for 131I radionuclide at a pH of 3.0 at room temperature on P1 and P2 are 77.7% and 84.2%, respectively. The sorption capacities of the two polymers demonstrate that P2 > P1, with capacities of 67.9 and 58.5 mg/g, respectively. Four linear kinetic models are investigated: pseudo-first order, pseudo-second order, Elovich, and Weber–Morris models. Regarding their calculated parameters, these models indicate that the adsorption process of I-ions on both P1 and P2 is controlled by chemisorption. Four equilibrium isotherm models (Redlich-Peterson, Langmuir, Freundlich, and Harkin-Jura) are investigated, revealing that the adsorption process is a monolayer and multilayer process on a heterogeneous surface.
Effect of Postoperative Tranexamic Acid on Recurrence Rate and Complications in Chronic Subdural Hematomas Patients: Preliminary Results of a Randomized Controlled Clinical Trial
Authors: Torres Marcus Vinícius Carneiro , Ribeiro Bernardo Duarte Chamon , Melo Marina Mendes , de Freitas Pedro Victor Vidal , Pahl Felix Hendrik , de Oliveira Matheus Fernandes , Rotta Jose Marcus 
Published: January 2023

Abstract
Introduction. Chronic subdural hematoma (CSDH) is a frequent neurosurgical disease, which mainly affects elderly patients. Tranexamic acid (TXA) has been hypothesized as an oral agent to avoid CSDH progression and/or recurrence. We performed an evaluation to determine whether the postoperative use of TXA reduces recurrence rate.
Method. A prospective, randomized and controlled trial. Patients with unilateral or bilateral chronic subdural hematoma undergoing surgical treatment by burr-hole were randomized as to whether or not to use TXA in the postoperative period. We evaluated image and clinical recurrence of CSDH at follow up of 6 months and potential clinical and/or surgical complications impact of TXA.
Results. Twenty-six patients were then randomized to the control group (52%) and twenty-four patients to the TXA group (48%). Follow-up ranged from 3 months to 16 months. There were no significant difference between baseline data in groups regarding to age, gender, use of antiplatelet or anticoagulants, smoking, alcoholism, systemic arterial hypertension, diabetes mellitus, hematoma laterality, hematoma thickness and drain use. Clinical and radiological recurrence occurred in 3 patients (6%), being 2 cases in TXA group (8.3%) and 1 in control group (3.8%). Postoperative complications occurred in 2 patients during follow-up (4%), being both cases in TXA group (8.3%), and none in the control group.
Discussion and Conclusion. Although TXA group had a higher recurrence rate (8.3%), there was no statistically significant difference between the two groups. Moreover, TXA group had 2 complications while control group had no complications. Although limited by experimental nature of study and small sample, our current data suggest that TXA should not be used as a potential agent to avoid recurrences of CSDH and might increase complication odds.
Angiotensin II-related activation of scleral fibroblasts and the role of retinal ganglion cell death in glaucoma
Authors: Oh Si Eun , Kim Jie Hyun , Shin Heejong , Kim Seong Ah , Park Chan Kee , Park Hae Young Lopilly 
Published: January 2023

Abstract
We identify the angiotensin II (AngII)-associated changes in the extracellular matrix (ECM), and the biomechanical properties of the sclera after systemic hypotension. Systemic hypotension was induced by administering oral hydrochlorothiazide. AngII receptor levels and ECM components in the sclera and biomechanical properties were evaluated by stress–strain relationship after systemic hypotension. The effect of inhibiting the AngII receptor with losartan was determined in the systemic hypotensive animal model and the cultured scleral fibroblasts from this model. The effect of losartan on retinal ganglion cell (RGC) death was evaluated in the retina. Both AngII receptor type I (AT-1R) and type II (AT-2R) increased in the sclera after systemic hypotension. Proteins related to the activation of fibroblasts (transforming growth factor [TGF]-β1 and TGF-β2) indicated that transformation to myofibroblasts (αSMA), and the major ECM protein (collagen type I) increased in the sclera after systemic hypotension. These changes were associated with stiffening of the sclera in the biomechanical analysis. Administering losartan in the Tenon’s tissue significantly decreased the expression of AT-1R, αSMA, TGF-β, and collagen type I in the cultured scleral fibroblasts and the sclera of systemic hypotensive rats. The sclera became less stiff after the losartan treatment. A significant increase in the number of RGCs and decrease in glial cell activation was found in the retina after the losartan treatment. These findings suggest that AngII has a role in scleral fibrosis after systemic hypotension and that inhibiting AngII could modulate the tissue properties of the sclera resulting in the protection of RGCs.
Cooperative phototherapy based on bimodal imaging guidance for the treatment of uveal melanoma
Authors: Huang Tong , Xu Xinzhi , Cheng Chen , Wang Jianxin , Yang Liping 
Published: January 2023

Abstract
Background
Uveal melanoma (UM) is the most common primary intraocular malignant tumor in adults, prone to metastasis and high mortality. Currently, eyeball enucleation commonly used in clinics will lead to permanent blindness and mental disorders. Thus, new methods are urgently needed to diagnose and treat UM early to preserve patients' vision.
Methods and results
Herein, multifunctional nanoparticles (NPs) were synthesized by loading chlorin e6 (Ce6) in poly-lactic-co-glycolic acid (PLGA) NPs and wrapping FeIII-TA on the outside (designated as FTCPNPs). Then, the synergistic photothermal therapy (PTT) and photodynamic therapy (PDT) antitumor effects of FTCPNPs excited by near-infrared (NIR) laser were evaluated. Moreover, we verified the mechanism of synergistic PTT/PDT leading to mitochondrial dysfunction and inducing tumor cell apoptosis. Additionally, FTCPNPs can be used as excellent magnetic resonance (MR)/photoacoustic (PA) imaging contrast agents, enabling imaging-guided cancer treatment. Finally, The NPs have good biological safety.
Conclusion
This noninvasive NIR light-triggered cooperative phototherapy can easily penetrate eye tissue and overcome the disadvantage of limited penetration of phototherapy. Therefore, cooperative phototherapy is expected to be used in fundus tumors. This treatment model is applied to UM for the first time, providing a promising strategy and new idea for integrating the diagnosis and treatment of UM.
Impact of early initiation of renin-angiotensin blockade on renal function and prognosis in patients with hypertensive emergency: A retrospective cohort study
Authors: Endo Keita , Hayashi Koichi , Hara Yuki , Miyake Akihiro , Takano Keisuke , Horikawa Takehiro , Yoshino Kaede , Sakai Masahiro , Kitamura Koichi , Ito Shinsuke , Imai Naohiko , Suzuki Toshihiko , Fujitani Shigeki 
Published: January 2023

Abstract
Background
Hypertensive emergency is a critical disease that causes multifaceted sequelae, including end-stage kidney disease and cardiovascular disease. Although the renin-angiotensin-aldosterone (RAA) system is enormously activated in this disease, there are few reports that attempt to characterize the effect of early use of RAA inhibitors (RASi) on the temporal course of kidney function.
Methods
This retrospective cohort study was conducted to clarify whether the early use of RASi during hospitalization offered more favorable benefits on short-term renal function and long-term renal prognosis in patients with hypertensive emergencies. We enrolled a total of 49 patients who visited our medical center with acute severe hypertension and multiple organ dysfunction between April 2012 and August 2020. Upon admission, the patients were treated with intravenous followed by oral antihypertensive drugs, including RASi and Ca channel blockers (CCB). Kidney function as well as other laboratory and clinical parameters were compared between RASi-treated and other antihypertensive drugs-treated group over 2 years.
Results
Antihypertensive treatment effectively reduced blood pressure from 222 ± 4/142 ± 3 to 140 ± 3/87 ± 2 mmHg at 2 weeks and eGFR was gradually restored from 33.2 ± 3.3 to 41.1 ± 4.1mL/min/1.73m2 at 1 year. The renal effect of antihypertensive drugs was particularly conspicuous when RASi was started in combination with other conventional antihypertensive drugs at the early period of hospitalization (2nd day [IQR: 1-5.5]) and even in patients with moderately to severely diminished eGFR (< 30 mL/min/1.73 m2) on admission. In contrast, CCB modestly restored eGFR during the observation period. Furthermore, renal survival probabilities were progressively deteriorated in patients who had manifested reduced eGFR (< 15mL/min/1.73 m2) or massive proteinuria (urine protein/creatinine ≥ 3.5 g/gCr) on admission. Early use of RASi was associated with a favorable 2-year renal survival probability (0.90 [95%CI: 0.77-1.0] vs. 0.63 [95%CI: 0.34–0.92] for RASi(+) and RASi(-), respectively, p = 0.036) whereas no apparent difference in renal survival was noted for CCB, β-blocker, α-blockers, or diuretics.
Conclusions
Early use of RASi contributes to the renal functional recovery from acute reduction in eGFR among patients with hypertensive emergencies. Furthermore, RASi offers more favorable effect on 2-year renal survival, compared with other antihypertensive drugs.
Various effects of 11,12 EET rescue wound healing in a combined model of diabetes and ischemia
Authors: Sommer Katharina , Jakob Heike , Lettenmeier Theresa , Henrich Dirk , Sterz Jasmina , Marzi Ingo , Frank Johannes 
Published: January 2023

Abstract
Chronic non-healing wounds caused by diabetes and ischemia. We analyzed the effects of 11,12 Epoxyeicosatrienoic acid (EET) in a combined model of hyperglycemia and ischemia in mice.
Hyperglycemia was induced by Streptozotozin 2 weeks prior to wounding. 3 days before wound creation 2 of the 3 suppling vessels of the moue ear were cautherized for ischemia. Either 11,12 EET or solvent for control was applied. Wound closure as well as TNF-α, TGF-β, SDF-1α, VEGF, CD31, and Ki67 was measured.
The wounds closed on day 14.4 ± 0.4 standard deviation (SD). 11,12 EET treatment enhanced healing to 9.8 ± 0.6 SD. TNF-α level was augmented on day 9 compared to control and receded on day 18. TGF-β seemed to be elevated all days observed after 11,12 EET treatment. SDF-1α was enhanced on day 6 and 9 by 11,12 EET, and VEGF on day 6 and 18 as well as CD13 on day 3, 6, and 18. 11,12 EET did not alter Ki67.
11,12 EET are able to rescue deteriorated wound healing in a combined model of hyperglycamia and ischemia by resolution of inflammation, augmentation of neovascularization and increasing expression of TGF-β as well as SDF-1α.
WITHDRAWN: Anticorrosive concert of expired drug acts as novel and potent inhibitor for deterioration of Low carbon steel in acidic Environment
Authors: M Gunasekaran , P Srinivasan 
Published: January 2023

Abstract
Frisium anticorrosive activity in corrosive environments was investigated. The performance of the inhibitor as studied by weight loss method along with surface morphological experiments SEM and AFM. The drug showed higher anti corrosive activity 91.66 % in 500 ppm, the above results further showed the scale of inhibition is depends on the concentration of frisium by increasing the concentration the inhibition efficiency of the drug as increased as well as increasing the temperature the inhibition rate was decreased. Impedance results showed charge transfer takes place between the metal surface and acid solution and frisium performed as a mixed type of inhibitor has proven by the polarization measurements. The drug was heavily adsorbed on the low carbon steel surface and is revealed by SEM and AFM studies. By analyzing the DFT values which leads to the accumulation of a thin layer on the metal surface. IR spectral studies have also confirmed the drug's adsorption on the metal surface.