bluuebunny/crossref_metadata_2025_split huggingface dataset:
Place of robotic surgery in completion lobectomy after anatomical segmentectomy
Authors: Piccoli Juliette , Seitlinger Joseph , Streit Arthur , Wollbrett Christophe , Siat Joelle , Renaud Stéphane 
Published: August 2023

Abstract

OBJECTIVES
Although segmentectomy is steadily increasing in early-stage non-small-cell lung cancer, recurrence in the ipsilateral lobe is also increasing. Completion lobectomy (CL) is a challenging procedure that has already been described in a few studies using video-assisted thoracic surgery or thoracotomy. In this study, we aimed to show the feasibility and safety of robot-assisted thoracic surgery in cases of CL.

METHODS
Among 2073 major resections performed between January 2018 and september 2022 in the Department of Thoracic Surgery at Nancy University Regional Hospital, we retrospectively included patients who underwent CL by robot-assisted thoracic surgery after previous segmentectomy for non-small-cell lung cancer. Data and perioperative results were described and analysed.

RESULTS
Seventeen patients underwent CL with a median recurrence time after previous segmentectomy of 18 months [interquartile range (IQR): 12]. Four patients (23.5%) had a pulmonary artery injury that was controlled, and no conversion to open thoracotomy was needed. The operative time was 150 min (IQR: 20), and blood loss was 300 ml (IQR: 150). The median postoperative chest tube duration was 2 days (IQR: 1), and the length of hospital stay was 3 days (IQR: 3), with no postoperative deaths.

CONCLUSIONS
Completion lobectomy is a challenging procedure due to severe adhesions surrounding vessels, which potentially could cause higher rate of PA bleeding than conventional surgeries. With experienced team and surgeons, CL with robotic surgery may be reported as a safe and feasible procedure.
Effects ofluxSgene on growth characteristics, biofilm formation, and antimicrobial resistance of multi-antimicrobial-resistantVibrio parahaemolyticusVp2015094 isolated from shellfish
Authors: Jiang Yanhua , Wang Peng , Qu Meng , Wang Ting , Li Fengling , Wang Lianzhu , Yao Lin 
Published: August 2023

AbstractAimsVibrio parahaemolyticus is an important foodborne pathogen worldwide, which can cause gastroenteritis. This study aimed to investigate the effect of quorum sensing system LuxS/AI-2-related gene luxS on the biological characteristics and antimicrobial resistance of V. parahaemolyticus Vp2015094 from shellfish, which carried a multi-antimicrobial-resistant plasmid.Methods and ResultsThe critical gene luxS related to the synthesis of AI-2 in V. parahaemolyticus Vp2015094 was knocked out by homologous recombination with suicide plasmid. The effect of luxS on the biological characteristics of V. parahaemolyticus was determined by comparing the growth, AI-2 activity, motility, biofilm formation ability, and antibiotic resistance between the wildtype strain and the luxS deletion mutant. Compared with wildtype strain, the production of AI-2, the motility and biofilm formation ability, antimicrobial resistance, and conjugation frequency of luxS deletion mutant strain were decreased. The transcriptome sequencing showed that the transcriptional levels of many genes related to motility, biofilm formation, antimicrobial resistance, and conjugation were significantly downregulated after luxS deletion.ConclusionsQuorum sensing system LuxS/AI-2-related gene luxS in V. parahaemolyticus Vp2015094 played an important role in growth characteristics, biofilm formation, antimicrobial resistance, and resistance genes’ transfer.
In situ generation of cold atmospheric plasma-activated mist and its biocidal activity against surrogate viruses for COVID-19
Authors: Upadrasta Aditya , Daniels Stephen , Thompson Thomas Philip , Gilmore Brendan , Humphreys Hilary 
Published: August 2023

Abstract

Aims
To provide an alternative to ultra violet light and vapourized hydrogen peroxide to enhance decontamination of surfaces as part of the response to the COVID-19 pandemic.

Methods and results
We developed an indirect method for in situ delivery of cold plasma and evaluated the anti-viral activity of plasma-activated mist (PAM) using bacteriophages phi6, MS2, and phiX174, surrogates for SARS-CoV-2. Exposure to ambient air atmospheric pressure derived PAM caused a 1.71 log10 PFU ml−1 reduction in phi6 titer within 5 min and a 7.4 log10 PFU ml−1 reduction after 10 min when the the PAM source was at 5 and 10 cm. With MS2 and phiX174, a 3.1 and 1.26 log10 PFU ml−1 reduction was achieved, respectively, after 30 min. The rate of killing was increased with longer exposure times but decreased when the PAM source was further away. Trace amounts of reactive species, hydrogen peroxide and nitrite were produced in the PAM, and the anti-viral activity was probably attributable to these and their secondary reactive species.

Conclusions
PAM exhibits virucidal activity against surrogate viruses for COVID-19, which is time and distance from the plasma source dependent.
NURBS-based surface generation from 3D images: spectral construction and data-driven model selection
Authors: Perney Antoine , Bordas Stéphane , Kerfriden Pierre 
Published: August 2023

Abstract
In this paper, we present a set of improved algorithms for recovering computer aided design (CAD-type) surface models from three-dimensional (3D) images. The goal of the proposed framework is to generate B-spline or non-uniform rational B-spline (NURBS) surfaces, which are standard mathematical representations of solid objects in digital engineering. To create a NURBS surface, we first compute a control network (a quadrilateral mesh) from a triangular mesh using the Marching Cubes algorithm and Discrete Morse theory. To create a NURBS surface, we first compute a triangular mesh using the Marching Cubes algorithm, then the control network (a quadrilateral mesh) is determined from the triangular mesh by using Discrete Morse theory. Discrete Morse theory uses the critical points of a specific scalar field defined over the triangulation to generate a quad mesh. Such a scalar field is obtained by solving a graph Laplacian eigenproblem over the triangulation. However, the resulting surface is not optimal. We therefore introduce an optimization algorithm to better approximate the geometry of the object. In addition, we propose a statistical method for selecting the most appropriate eigenfunction of the graph Laplacian to generate a control network that is neither too coarse nor too fine, given the precision of the 3D image. To do this, we set up a regression model and use an information criterion to choose the best surface. Finally, we extend our approach by taking into account both model and data uncertainty using probabilistic regression and sampling the posterior distribution with Hamiltonian Markov Chain Monte Carlo.
Effectiveness of online mindfulness-based interventions for cancer patients: a systematic review and meta-analysis
Authors: Fan Meiling , Wang Yang , Zheng Lufang , Cui Miao , Zhou Xiuling , Liu Zengxia 
Published: August 2023

Abstract

Purpose
Cancer is the second leading cause of mortality worldwide. Cancer negatively affects individuals’ quality of life and overall health. Mindfulness-based interventions appear to be promising in the reduction of cancer- and treatment-related symptoms. This review aimed to determine the effectiveness of online mindfulness-based interventions on distress, anxiety, depression, stress, mindfulness, sleep disturbance, quality of life, rumination, fear of cancer recurrence, fatigue and post-traumatic growth among adult cancer patients.

Methods
A literature search was conducted across five electronic databases. Only randomized controlled trials were eligible. Two reviewers independently screened the studies, extracted data, and performed quality assessment using the Cochrane risk of bias assessment tool. Meta-analyses were conducted using review manager software, and standardized mean difference was used to determine intervention effects. Heterogeneity was examined using the I2 statistics.

Results
Ten studies were included with a total of 962 participants. Analyses revealed that online mindfulness-based interventions was effective in reducing distress (I2 = 98%；standardized mean difference = −2.21，95% confidence interval: −3.84 to 0.57；P = 0.008)， depression (I2 = 45%；standardized mean difference = −0.33，95% confidence interval: −0.64 to −0.03；P = 0.03), stress (I2 = 97%；standardized mean difference = −2.14，95% confidence interval: −4.24 to −0.03；P = 0.05) and sleep disturbance (I2 = 54%；standardized mean difference = −0.30，95% confidence interval: −0.59 to −0.01；P = 0.04), and improving quality of life (I2 = 94%；standardized mean difference = 0.92，95% confidence interval: 0.09–1.76；P = 0.03). The online mindfulness-based interventions had no significant effects on anxiety, mindfulness, rumination, fear of cancer recurrence, fatigue and post-traumatic growth. Subgroup analyses revealed that online mindfulness-based interventions resulted in higher effect sizes for distress when delivered by website than application, significantly higher effect sizes were also found for online mindfulness-based interventions with guidance, but not on treatment or cancer type. For sleep disturbance, and quality of life, no significant differences between subgroups were found.

Conclusion
These results provide preliminary support that online mindfulness-based interventions may be feasible and acceptable, which can be used as an adjuvant therapy for the management of cancer-related symptoms among cancer patients.
The Cancer Moonshot Immuno-Oncology Translational Network at 5: accelerating cancer immunotherapies
Authors: Annapragada Ananth , Sikora Andrew G , Marathe Himangi , Liu Song , Demetriou Michael , Fong Lawrence , Gao Jinming , Kufe Donald , Morris Zachary S , Vilar Eduardo , Sharon Elad , Hutson Alan , Odunsi Kunle 
Published: August 2023

Abstract
The Immuno-Oncology Translational Network (IOTN) was established in 2018 as part of the Cancer Moonshot. In 2022, President Joe Biden set new goals to reduce the cancer death rate by half within 25 years and improve the lives of people with cancer and cancer survivors. The IOTN is focused on accelerating translation of cancer immunology research, from bench to bedside, and improving immunotherapy outcomes across a wide array of cancers in the adult population. The unique structure and team science approach of the IOTN is designed to accelerate discovery and evaluation of novel immune-based therapeutic and prevention strategies. In this article, we describe IOTN progress to date, including new initiatives and the development of a robust set of resources to advance cancer immunology research. We summarize new insights by IOTN researchers, some of which are ripe for translation for several types of cancers. Looking to the future, we identify barriers to the translation of immuno-oncology concepts into clinical trials and key areas for action and improvements that are suitable for high-yield investments. Based on these experiences, we recommend novel National Institutes of Health funding mechanisms and development of new resources to address these barriers.
Temperature-dependence mechanical characteristics investigation of Cu wire and corresponding high strain rate plasticity behaviors enabled by Johnson–Cook constitutive model
Authors: Liu De-Shin , Wen Po-Chun , Zhuang Zhen-Wei , Chao Yung-Ching , Huang Pei-Chen 
Published: August 2023

Abstract
The temperature-dependence mechanical characteristics of 4N Cu wire with 25, 30 and 38 μm diameters are investigated via the utilization of micro-tensile tests. Measured data revealed that the concerned mechanical characteristics, Young's modulus and yield stresses, are significantly degraded under high testing temperature, and the variation of aforementioned characteristics degradation are almost linear proportional to the temperature increment. Trapezoidal and standard triangle loop formation of Cu wire are simulated based on the finite element method, the simulated looping profiles of Cu wires are compared to the Au wires and the Cu wire is regarded as the improved solution for the high loop height wire formation. Moreover, the Johnson–Cook constitutive model is utilized to describe the plasticity of Cu wire in accordance with the experimental data under different temperature levels. Accordingly, the comprehensive mechanical characteristics’ investigation of 4N Cu wire are systemically demonstrated and explored.
A Measure of Caregivers’ Distress-Promoting Behaviors During Toddler Vaccination: Validation of the OUCHIE-RV
Authors: Badovinac Shaylea D , Flora David B , Edgell Heather , Flanders Dan , Garfield Hartley , Weinberg Eitan , Savlov Deena , Pillai Riddell Rebecca R 
Published: August 2023

Abstract

Objective
The current study discusses the development and preliminary validation of an observational measure of caregivers’ distress-promoting behavior (OUCHIE-RV) in the context of toddler routine vaccination.

Methods
Measure validation was based on a sample of caregiver–toddler dyads (N = 223) from a longitudinal cohort-sequential study who were observed during toddlers’ 12-, 18-, or 24-month routine vaccinations. Validity was assessed using correlations and cross-lagged path analysis and associations were tested between OUCHIE-RV composite scores and toddlers’ pain-related distress as well as caregivers’ state anxiety, soothing behaviors, heart rate, and heart rate variability. Interrater reliability was examined using intraclass correlations (ICC) and kappa coefficients.

Results
Results of a cross-lagged path analysis indicated positive concurrent (β = .27 to β = .37) and cross-lagged predictive associations (β = .01 to β = .34) between OUCHIE-RV composite scores (reflecting the frequency and intensity of caregivers’ distress-promoting behavior) and toddlers’ pain-related distress. OUCHIE-RV composite scores were negatively associated with caregivers’ concurrent use of physical comfort (r = −.34 to −.24) and rocking (r = −.36 to −.19) and showed minimal associations with caregivers’ use of verbal reassurance (r = .06 to .12), state anxiety (r = −.02 to r = .09), heart rate (r = −.15 to r = .05), and heart rate variability (r = −.04 to r = .13). Interrater reliability was strong (Cohen’s k = .86 to .97, ICC = .77 to .85).

Conclusions
Findings provide support for the validity and reliability of the OUCHIE-RV as a research tool for measuring caregiver behaviors that promote toddlers’ pain-related distress during routine vaccinations and contribute to a better understanding of the dynamics of caregiver–toddler interaction in acute pain contexts.
A flexible mixed model for age-dependent performance: application to golf
Authors: Baker Rose D , McHale Ian G 
Published: August 2023

Abstract
We present a new mixed linear model for the relationship between age and performance. The model allows for random effects at the nodes of a barycentric interpolation, such that performance evolves with age in a non-prescriptive way. We use the model to investigate the effects of age on performance in golf and find that performance peaks in the 30s and then declines after that. We disaggregate performance into its constituent components and find that driving, which tends to require power and speed, deteriorates consistently from the early 20s, whilst putting, which requires touch and finesse, remains strong until the late 40s. Our model can be used in other settings, and requires only that measures of performance exist.
Synergistic action of indole-3-carbinol with membrane-active agents against multidrug-resistant Gram-negative bacteria
Authors: Wang Tso-Ping , Yeh Tzu-Hui , Lo Chung-Cheng , Lin Kuan-Hua , Huang Mei-Han , Lo Horng-Ren 
Published: August 2023

Abstract
The purpose of this study was to evaluate the antimicrobial activity of indole-3-carbinol (I3C) with membrane-active agents, namely carbonyl cyanide 3-chlorophenylhydrazone (CCCP) and ethylenediaminetetraacetic acid (EDTA) against multidrug-resistant (MDR) Gram-negative bacteria and bacterial persisters. The determination of minimal inhibitory concentration (MIC) showed that I3C was effective against Acinetobacter baumannii (3.13‒6.25 × 10−3 mol l−1), Klebsiella pneumoniae (8 × 10−3 mol l−1), Pseudomonas aeruginosa (6.25‒12.5 × 10−3 mol l−1), and Escherichia coli (6.25‒12.5 × 10−3 mol l−1). Our study demonstrated that EDTA synergistically enhanced the bactericidal activity of I3C against most MDR Gram-negative bacteria isolates and contributed to an 8- to 64-fold MIC reduction compared with that of I3C alone, yet CCCP only displayed synergy with I3C against P. aeruginosa and A. baumannii. The EDTA–I3C combination also significantly reduced the viable number of testing bacteria (P = 7.2E-05), effectively reduced bacterial persisters, and repressed bacterial growth compared with that the use of I3C alone. Our data demonstrate that use of EDTA as adjuvant molecules can effectively improve the antibacterial activity of I3C and may help to reduce the development of antimicrobial resistance.
Mapping circumgalactic medium observations to theory using machine learning
Authors: Appleby Sarah , Davé Romeel , Sorini Daniele , Lovell Christopher C , Lo Kevin 
Published: August 2023

ABSTRACT
We present a random forest (RF) framework for predicting circumgalactic medium (CGM) physical conditions from quasar absorption line observables, trained on a sample of Voigt profile-fit synthetic absorbers from the simba cosmological simulation. Traditionally, extracting physical conditions from CGM absorber observations involves simplifying assumptions such as uniform single-phase clouds, but by using a cosmological simulation we bypass such assumptions to better capture the complex relationship between CGM observables and underlying gas conditions. We train RF models on synthetic spectra for H i and selected metal lines around galaxies across a range of star formation rates, stellar masses, and impact parameters, to predict absorber overdensities, temperatures, and metallicities. The models reproduce the true values from simba well, with normalized transverse standard deviations of 0.50–0.54 dex in overdensity, 0.32–0.54 dex in temperature, and 0.49–0.53 dex in metallicity predicted from metal lines (not H i), across all ions. Examining the feature importance, the RF indicates that the overdensity is most informed by the absorber column density, the temperature is driven by the line width, and the metallicity is most sensitive to the specific star formation rate. Alternatively examining feature importance by removing one observable at a time, the overdensity and metallicity appear to be more driven by the impact parameter. We introduce a normalizing flow approach in order to ensure the scatter in the true physical conditions is accurately spanned by the network. The trained models are available online.
Barless flocculent galaxies: a dynamic puzzle
Authors: Zakharova Daria , Sotnikova Natalia Ya , Smirnov Anton A , Savchenko Sergey S 
Published: August 2023

ABSTRACT
We draw attention to the bright galaxies that do not show a bar in their structure but have a flocculent spiral structure. Using the THINGS and HERACLES kinematic data for four barless galaxies (NGC 2841, NGC 3512, NGC 5055, NGC 7331), we built their mass models including dark haloes. We concluded that the fraction of the dark matter does not exceed 50 per cent within the optical radii of the galaxies. This is too little to explain the lack of a bar in these galaxies. In an attempt to understand the featureless structure of these galaxies, we constructed several N-body models with an initially reduced content of dark matter. We concluded that, in addition to the low mass of the dark halo, the decisive factor that leads to a barless disc is the start from an initially unstable state. An isolated dynamically cold disc (with the Toomre parameter Q &lt; 0.5) settled into rotational equilibrium passes through the short stage of violent instability with fragmentation and formation of stellar clumps. After that, it evolves passively and ends up with a featureless structure. We assume that the barless flocculent galaxies studied in this work may be descendants of galaxies at high redshifts with rotation curves that are consistent with the high mass fraction of baryons relative to the total dark matter halo.
Evidence that bivalve burrowing is mediated by serotonin receptors: activation of foot inflation and protrusion by serotonin, serotonergic ligands and SSRI-type antidepressants in three species of freshwater bivalve
Authors: Fong Peter P , Blaszczyk Rebecca A , Butler Mary G , Stergio Jake W 
Published: August 2023

ABSTRACT
Foot inflation and protrusion in bivalve molluscs is part of a sequence of events necessary for burrowing into the substrate. Although this process been observed after exogenous exposure to the neurotransmitter serotonin [5-hydroxytryptamine (5-HT)] and by some selective serotonin reuptake inhibitor (SSRI) type antidepressants, no study has shown that foot inflation and protrusion as a precursor to burrowing is under serotonergic control. In order to elucidate the physiological mechanism mediating this response, we tested over 2,000 freshwater bivalves in three species by exposing them to 5-HT, two 5-HT receptor agonists, two receptor antagonists and five antidepressants. Fingernail clams (Sphaerium striatinum), Asian clams (Corbicula fluminea) and unionid mussels (Elliptio complanata) all showed significant foot inflation or foot protrusion when exposed to 5-HT and the serotonergic agonists 8-OH-DPAT and alpha-methyl 5-HT. Some SSRI-type antidepressants (fluoxetine and fluvoxamine) also significantly induced these responses in all three species but were not as potent at the concentrations tested. In S. striatinum and C. fluminea, a 2-h exposure to the 5-HT2 receptor antagonists mianserin and cyproheptadine effectively blocked foot inflation induced by 5-HT and 8-OH-DPAT. The 5-HT receptor mediating this response is thus sensitive to mammalian 5-HT1 and 5-HT2 receptor ligands, supporting the hypothesis that serotonin mediates the initial step in burrowing.
Transitions in vascular ultrasonography findings of temporal arteritis in a GCA case with progressive temporal headache and visual impairment
Authors: Kawamoto Toshio , Ogasawara Michihiro , Murayama Go , Matsuki-Muramoto Yuko , Hayashi Eri , Harada Mariko , Kusaoi Makio , Matsushita Masakazu , Yamaji Ken , Tamura Naoto 
Published: August 2023

ABSTRACT
The European League Against Rheumatism and the American College of Rheumatology have stated that the halo sign on vascular ultrasonography (v-US) is relevant in diagnosing giant cell arteritis (GCA) and is equivalent to temporal artery biopsy. However, there are only a few reports about transitions in v-US findings after glucocorticoid (GC) therapy. We report the transitions in the v-US findings in a case of GCA after GC therapy. The patient had rapidly progressive symptoms, and there were concerns about blindness. After GC therapy, we first observed improvement in headache and visual impairment symptoms within 1 week, followed by rapid improvement in laboratory findings within 2 weeks. Subsequently, there were improvements in v-US findings after more than 2 months. In conclusion, these findings showed a dissociation between improvements in clinical symptoms and v-US findings of the temporal artery. Additionally, this case suggests that regular examination of v-US findings is useful in evaluating GCA with evident vascular wall thickness before GC therapy.