bluuebunny/crossref_metadata_2025_split huggingface dataset:
A simulation-based approach for estimating the time-dependent reproduction number from temporally aggregated disease incidence time series data
Authors: Ogi-Gittins I , Hart WS , Song J , Nash RK , Polonsky J , Cori A , Hill EM , Thompson RN 
Published: September 2023

AbstractTracking pathogen transmissibility during infectious disease outbreaks is essential for assessing the effectiveness of public health measures and planning future control strategies. A key measure of transmissibility is the time-dependent reproduction number, which has been estimated in real-time during outbreaks of a range of pathogens from disease incidence time series data. While commonly used approaches for estimating the time-dependent reproduction number can be reliable when disease incidence is recorded frequently, such incidence data are often aggregated temporally (for example, numbers of cases may be reported weekly rather than daily). As we show, commonly used methods for estimating transmissibility can be unreliable when the timescale of transmission is shorter than the timescale of data recording. To address this, here we develop a simulation-based approach involving Approximate Bayesian Computation for estimating the time-dependent reproduction number from temporally aggregated disease incidence time series data. We first use a simulated dataset representative of a situation in which daily disease incidence data are unavailable and only weekly summary values are reported, demonstrating that our method provides accurate estimates of the time-dependent reproduction number under those circumstances. We then apply our method to two previous outbreak datasets consisting of weekly influenza case numbers from 2019-20 and 2022-23 in Wales (in the United Kingdom). Our simple-to-use approach allows more accurate estimates of time-dependent reproduction numbers to be obtained during future infectious disease outbreaks.
Phosphoproteomics reveals content and signaling differences between neonatal and adult platelets
Authors: Thom Christopher S , Davenport Patricia , Fazelinia Hossein , Liu Zhi-Jian , Zhang Haorui , Ding Hua , Roof Jennifer , Spruce Lynn A , Ischiropoulos Harry , Sola-Visner Martha 
Published: September 2023

AbstractBackground and ObjectiveRecent clinical studies have shown that transfusions of adult platelets increase morbidity and mortality in preterm infants. Neonatal platelets are hyporesponsive to agonist stimulation, and emerging evidence suggests developmental differences in platelet immune functions. This study was designed to compare the proteome and phosphoproteome of resting adult and neonatal platelets.MethodsWe isolated resting umbilical cord blood-derived platelets from healthy full term neonates (n=9) and resting blood platelets from healthy adults (n=7), and compared protein and phosphoprotein contents using data independent acquisition mass spectrometry.ResultsWe identified 4745 platelet proteins with high confidence across all samples. Adult and neonatal platelets clustered separately by principal component analysis. Adult platelets were significantly enriched for immunomodulatory proteins, including β2 microglobulin and CXCL12, whereas neonatal platelets were enriched for ribosomal components and proteins involved in metabolic activities. Adult platelets were enriched for phosphorylated GTPase regulatory enzymes and proteins participating in trafficking, which may help prime them for activation and degranulation. Neonatal platelets were enriched for phosphorylated proteins involved in insulin growth factor signaling.ConclusionsUsing state-of-the-art mass spectrometry, our findings expanded the known neonatal platelet proteome and identified important differences in protein content and phosphorylation compared with adult platelets. These developmental differences suggested enhanced immune functions for adult platelets and presence of a molecular machinery related to platelet activation. These findings are important to understanding mechanisms underlying key platelet functions as well as the harmful effects of adult platelet transfusions given to preterm infants.
Crossmodal correspondence of natural amplitude modulations
Authors: Lemus Luis , Morán Isaac , Melchor Jonathan , Figueroa Tonatiuh , Matta Miguel , Cabrera Elizabeth 
Published: September 2023

ABSTRACTCrossmodal correspondence is the ability to recognize objects from different sensory modalities to be similar. Here, we investigated the capacity of humans to perform crossmodal discriminations between visual, acoustic, and tactile stimuli modulated in amplitudes of low-pass filtered envelopes obtained from natural sounds. We found that the perception of crossmodal correspondence emerged from the number of amplitude prominences in each stimulus rather than from temporal variations. Therefore, we propose saliency as the supramodal trade coin of temporal modulations.
Reinforcement learning during locomotion
Authors: Wood Jonathan M , Kim Hyosub E , Morton Susanne M 
Published: September 2023

AbstractWhen learning a new motor skill, people often must use trial and error to discover which movement is best. In the reinforcement learning framework, this concept is known as exploration and has been observed as increased movement variability in motor tasks. For locomotor tasks, however, increased variability decreases upright stability. As such, exploration during gait may jeopardize balance and safety, making reinforcement learning less effective. Therefore, we set out to determine if humans could acquire and retain a novel locomotor pattern using reinforcement learning alone. Young healthy male and female humans walked on a treadmill and were provided with binary reward feedback (success or failure only) to learn a novel stepping pattern. We also recruited a comparison group who walked with the same novel stepping pattern but did so by correcting for target error, induced by providing real time veridical visual feedback of steps and a target. In two experiments, we compared learning, motor variability, and two forms of motor memories between the groups. We found that individuals in the binary reward group did, in fact, acquire the new walking pattern by exploring (increased variability). Additionally, while reinforcement learning did not increase implicit motor memories, it resulted in more accurate explicit motor memories compared to the target error group. Overall, these results demonstrate that humans can acquire new walking patterns with reinforcement learning and retain much of the learning over 24 hours.Significance StatementHumans can learn some novel movements by independently discovering the actions that lead to success. This discovery process, exploration, requires increased motor variability to determine the best movement. However, in bipedal locomotion especially, increasing motor variability decreases stability, heightening the risk of negative outcomes such as a trip, injury, or fall. Despite this stability constraint, the current study shows that individuals do use exploration to find the most rewarding walking patterns. This form of learning led to improved explicit retention but not implicit aftereffects. Thus, the reinforcement learning framework can explain findings across a wide range of motor and cognitive tasks, including locomotion.
Explaining Deep Learning-Based Representations of Resting State Functional Connectivity Data: Focusing on Interpreting Nonlinear Patterns in Autism Spectrum Disorder
Authors: Kim Young-geun , Ravid Orren , Zhang Xinyuan , Kim Yoojean , Neria Yuval , Lee Seonjoo , He Xiaofu , Zhu Xi 
Published: September 2023

AbstractBackgroundResting state Functional Magnetic Resonance Imaging fMRI (rs-fMRI) has been used to study brain function in psychiatric disorders, yielding insight into brain organization. However, the high dimensionality of the rs-fMRI data presents challenges, and requires dimensionality reduction before applying machine learning techniques. Neural networks, specifically variational autoencoders (VAEs), have been instrumental in extracting low-dimensional latent representations of resting state functional connectivity patterns, addressing the complex nonlinear structure of rs-fMRI. However, interpreting those latent representations remains a challenge. This paper aims to address this gap by creating explainable VAE models and testing their utility using rs-fMRI data in autism spectrum disorder (ASD).MethodsOne-thousand one hundred and fifty participants (601 HC and 549 patients with ASD) were included in the analysis. We extracted functional connectivity correlation matrices from the preprocessed rs-fMRI data using Power atlas with 264 ROIs. Then VAEs were trained in an unsupervised fashion. Lastly, we introduce our latent contribution scores to explain the relationship between estimated representations and the original rs-fMRI brain measures.ResultsWe quantified the latent contribution scores for the ASD and control groups at the network level. We found that both ASD and control groups share the top network connectivity that contribute to all estimated latent components. For example, latent 0 was driven by resting state functional connectivity patterns (rsFC) within ventral attention network in both the ASD and control. However, significant differences in the latent contribution scores between the ASD and control groups were discovered within the ventral attention network in latent 0 and the sensory/somatomotor network in latent 2.ConclusionThis study introduced latent contribution scores to interpret nonlinear patterns identified by VAEs. These scores effectively capture changes in each observed rsFC features as estimated latent representation changes, enabling an explainable deep learning model to better understand the underlying neural mechanism of ASD.
Stem cell proliferation and differentiation during larval metamorphosis of the model tapewormHymenolepis microstoma
Authors: Montagne Jimena , Preza Matías , Koziol Uriel 
Published: September 2023

AbstractTapeworm larvae cause important diseases in humans and domestic animals. During infection, the first larval stage undergoes a metamorphosis where tissues are formedde novofrom a population of stem cells called germinative cells. This process is difficult to study for human pathogens, as these larvae are infectious and difficult to maintain in the laboratory. In this work, we analyzed cell proliferation and differentiation during larval metamorphosis in the model tapewormHymenolepis microstoma, byin vivolabelling of proliferating cells with the thymidine analogue 5-ethynyl-2′-deoxyuridine (EdU), tracing their differentiation with a suite of specific molecular markers for different cell types. Proliferating cells are very abundant and fast-cycling during early metamorphosis: the total number of cells duplicates every ten hours, and the length of G2 is only 75 minutes. New tegumental, muscle and nerve cells differentiate from this pool of proliferating germinative cells, and these processes are very fast, as differentiation markers for neurons and muscle cells appear within 24 hours after exiting the cell cycle, and fusion of new cells to the tegumental syncytium can be detected after only 4 hours. Tegumental and muscle cells appear from early stages of metamorphosis (24 to 48 hours post-infection); in contrast, most markers for differentiating neurons appear later, and the detection of synapsin and neuropeptides correlates with scolex retraction. Finally, we identified populations of proliferating cells that express conserved genes associated with neuronal progenitors and precursors, suggesting the existence of tissue-specific lineages among germinative cells. These results provide for the first time a comprehensive view of the development of new tissues during tapeworm larval metamorphosis, providing a framework for similar studies in human and veterinary pathogens.
Facilities management and clients satisfaction nexus in hotels in secondary cities in Ghana: A study of selected hotels in Wa
Authors: Alhassan Tahiru , Kidido Joseph Kwaku 
Published: September 2023

Purpose
This study aims to assess how the provision of facilities management (FM) services influences customer satisfaction in hotels in secondary cities. This study focussed on customer satisfaction in relation to specific FM services such as cleaning, maintenance, security, internet/information technology and air conditioner servicing.

Design/methodology/approach
The study used a case study design. Simple random and purposive sampling methods were used to select the hotels and the respondents. The study used a survey based on the SERVQUAL model to collect data from 136 respondents. Six hotel managers were also interviewed.

Findings
There were disparities in customer satisfaction across the various hotel categories based on the assessment indicators used. Thus, customer satisfaction with FM services was not influenced by hotel ratings. On the calibre of staff handling FM activities, none of the hotels had a professional facilities manager. The hotel managers were in charge of FM activities, which affected the provision of FM services. Generally, customers in all the selected hotels were not satisfied with the quality of FM services. Specifically, the overall mean gap score was very low (−3.20), which meant that customers’ expectations far exceeded their perceptions, hence, their dissatisfaction. Tangible(s) of services were customers’ least appreciated (−1.04) dimension. This meant that hotels did not pay much attention to the physical (place) aspect of their FM activities. This should engage the attention of hospitality industry regulators and policymakers, given the current global health crisis caused by Covid-19 and its variance.

Originality/value
The study demonstrates customer satisfaction with FM services in hotels in secondary cities. Practically, hotels can become very competitive if they consider the findings of the study to provide effective customer-oriented FM services.
Measuring customer satisfaction in electronic commerce: the impact of e-service quality and user experience
Authors: Mamakou Xenia J. , Zaharias Panagiotis , Milesi Maria 
Published: September 2023

PurposeThe purpose of this study is to explore the interplay between electronic service quality, user experience (UX) and overall customer satisfaction. Additionally, it aims to assess the suitability of E-S-QUAL and UX metrics within the cultural context of Greece.Design/methodology/approachData were collected from 310 Internet users based on their last online purchase from an e-retail website. To evaluate the conceptual model, the authors used partial least squares structural equation modeling (PLS-SEM).FindingsThe findings of this study validate the scales' reliability and validity in the realm of electronic commerce (e-commerce) in Greece. The findings also emphasize the favorable association between e-service quality and UX with overall satisfaction, while indicating that e-service quality plays a partial mediating role in the relationship between UX and customer satisfaction.Originality/valueThe authors' study enhances the existing theory by introducing a new multi-dimensional conceptual framework that illuminates the relative importance of the dimensions within the scales. Additionally, it offers valuable insights into the impacts of e-service quality and UX on overall satisfaction, providing managers and practitioners with a tool to evaluate the quality of their electronic services and make necessary adjustments to meet the needs of their customers.
Covid-19 pandemic and firm performance: evidence on industry differentials and impacting channels
Authors: Ngo Hang Thi , Duong Ha Ngan 
Published: September 2023

PurposeThis study explores the impacts of Covid-19 on the performance of firms operating in different industries, and further discovers suspected impacting channels through which Covid-19 is significantly associated with firm performance.Design/methodology/approachA dataset of 402 listed firms from 2017Q1 to 2021Q4 is proceeded with high dimensional fixed effect (firm-quarter fixed effects) models and difference-in-difference models supported by propensity score matching. A thorough robustness testing procedure with a falsification test with a hypothetical event is applied.FindingsThe study asserts that the pandemic has remarkably hurt the businesses in industries that are more vulnerable to the coronavirus and governmental response policies. Adding to the confirmation of sales and expense channels, new channels – competition and short-term receivables –through which the negative impact of the pandemic is passed on firms is also examined.Originality/valueFirst, this study is to be the first comprehensively investigate and affirm the varying impact of Covid-19 on the business performance of listed firms from different industries in Vietnam, providing additional insight into this research field in Vietnam and emerging economies. Second, the authors examine possible channels paving the way for the impact of Covid-19 on firms' performance and especially explore new channels associated with competition and short receivables. Third, the findings help to form the recommendations for Vietnamese firms, and the study could be replicated for other emerging countries under other similar infectious diseases-driven crises.Peer reviewThe peer review history for this article is available at: https://publons.com/publon/10.1108/IJSE-02-2023-0072
A circular innovation strategy in a supply network context: evidence from the packaging industry
Authors: Cantu Chiara Luisa , Tunisini Annalisa 
Published: September 2023

Purpose
The research question is how can a company implement a circular innovation in a supply network context? Leveraging the main conceptual and interpretative models of the industrial marketing and purchasing thinking, this study aims to investigate the interplay between the process of circular innovation development and the changes in the structure and dynamics of the supply network in which innovation takes place.

Design/methodology/approach
This research applies a case study design focusing on participant interaction dynamics. The case relates to an industrial company producing an innovative coating solution for compostable packaging. The data used to develop the case study came from multiple sources but primarily from semistructured interviews that cover the implementation of the circular innovation and the configuration of the circular network.

Findings
The dynamics of interconnected relationships can configure a circular network that interconnects business and non business actors through vertical, horizontal and heterogeneous relationships. The network configuration is supported by the new mobilizer actor that facilitates the sharing of circular knowledge within the circular network, together with the sharing of a market orientation and entrepreneurial orientation within the supply network, through the educational learning path.

Originality/value
This paper aims to contribute to a new understanding of how circular innovation can be developed, adopted and diffused. In a network, when circular innovation takes place, the focal issue is not the new product or technology in itself but how such innovation is developed and implemented by and through the reconfiguration of the business and non-business relationships into circular network.
How stakeholders collaborate? Meeting the challenges and availing the opportunities of military heritage tourism
Authors: Mahajan Prachi , Gupta Bharti , Pedapalli Sarath Chandra Kanth 
Published: September 2023

PurposeThe goal of this study is to identify the problems of marketing military heritage as a tourism resource as well as to show how studies are linking the tourism industry with military historical sites to valorize epic wars and great tragedies as tourism development resources.Design/methodology/approachIn this study, evaluation of recently published research papers, articles and publications on military tourism is conducted.FindingsWhile most DMOs (Destination Management Organizations) and tourism organizations have been slow to acknowledge the potential benefits of military heritage tourism, the examples offered show how stakeholders can help promote military heritage tourism.Practical implicationsThe study has suggested managerial implications that will aid in the integration of stakeholder participation in the development of military heritage tourism.Originality/valueThis paper examines the constraints and potential benefits of military heritage tourism, as well as collaboration between stakeholders and military historic sites.
The differences in the implications of participative decision-making and paternalistic leadership for teachers' perceived stress in the education system of the Israeli Arab minority
Authors: Nassir Misaa , Benoliel Pascale 
Published: September 2023

PurposeStudies have shown that teachers' perceptions and expectations of their working environment shape their perceived stress. The present study draws upon implicit leadership theory and builds on the job demands-control (JD-C) model to investigate whether there are differences in the implications of participative decision-making and paternalistic leadership for teachers' perceived stress in the Israeli Arab education system.Design/methodology/approachData were collected through validated questionnaires returned by a two-stage cluster random sampling of 350 teachers randomly chosen from 70 Israeli Arab elementary schools. Paternalistic leadership and participative decision-making were considered as group-level variables to lower the risk of common method variance. The proposed model was tested through hierarchical regression analysis. Finally, to test the hypothesis that paternalistic leadership and participative decision-making standardized beta weights were statistically significantly different from each other, their corresponding 95% confidence intervals were estimated via bias corrected bootstrap (1000 re-samples).FindingsThe findings indicated differences in the levels of the principal's paternalistic leadership and participative decision-making as perceived by the Israeli Arab teachers. Also, the results indicated that participative decision-making was negatively correlated with teachers' perceived stress beyond the influence of paternalistic leadership.Originality/valueExamining teachers' working conditions and resources can be important since they affect teachers' perceived stress, which may in turn affects school results in the Arab education system in Israel. This study can contribute to the development of training programs for teachers to improve and adapt principals' leadership practices to the sociocultural context of the Arab education system in Israel.