bluuebunny/crossref_metadata_2025_split huggingface dataset:
How renewable energy and service growth influence environmental quality: Evidence from a sustainable development perspective
Authors: Chaouali Imen , Ben Jebli Mehdi , Strielkowski Wadim 
Published: April 2023

AbstractThe present study inspects the relationships between the carbon dioxide (CO2) emissions, real GDP, renewable and non‐renewable energy consumption, as well as the service growth for top ten countries (TTC) in service activities. The empirical modeling used in the study involves the procedures of cointegration and tests of Granger causality to inspect the dynamic interaction between the variables during the period from 1980 to 2018. The results of the present study suggest that the variables are cross‐sectionally dependent. In addition, the variables appear to be cointegrated based on several tests. The long‐run outcomes revealed an inversed U‐shaped form between emissions‐GDP proving the validity of the environmental Kuznets curve assumption. The fully modified ordinary least squares and dynamic OLS estimates show that the non‐renewable energy and economic growth contribute to the increase of CO2emissions, while service value‐added leads to decrease emissions. Furthermore, the renewable energy coefficient comes through as negative but insignificant for the selected panel. The TTC in service should stimulate the usage of renewable energy in various service events for following the path of sustainable development. Devising the investment plans associated with the use of renewable energies is quite essential for the advancement of the service sector leading to mitigating emissions portion.
Effect of Ramadan fasting on chronic inflammation markers and gut bacterial endotoxins among Egyptian hemodialysis patients
Authors: Samaan Emad , Eldeeb Ahmed A. , Ibrahim Ahmed B. , Erman Mohammed , Sabry Alaa A. , Mahmoud Mostafa A. 
Published: April 2023

AbstractBackgroundChronic kidney disease (CKD) is associated with a state of chronic inflammation. This study aimed to investigate effects of Ramadan fasting on the markers of chronic inflammation and gut bacterial endotoxin levels in maintenance hemodialysis.MethodA prospective self‐controlled observational study included 45 patients. Serum levels of High Sensitive CRP (hsCRP), indoxyl sulfate, and trimethylamine‐n‐levels were measured within a week before and a week after Ramadan fasting.ResultsTwenty‐seven patients have fasted more than 15 days (29 ± 2.2 days). The levels of high sensitive C‐reactive protein (hsCRP) (median of 62 mg/L vs. 91 mg/L), trimethylamine‐n‐oxide (TMAO) (median of 4.5 μmoL/L vs. 17 μmoL/L), platelet‐to‐lymphocyte ratio (PLR) (mean of 98.9 mg/L vs. 111.8 mg/L) and neutrophil‐to‐lymphocyte ratio (NLR) (median of 1.56 vs. 1.59) were significantly lower after Ramadan fasting with p < 0.001, p < 0.001, p < 0.001, and p = 0.04, respectively.ConclusionA beneficial effect of Ramadan fasting on levels of bacterial endotoxins and markers of chronic inflammation in hemodialysis patients was observed.
Characterization and mechanisms of radioresistant lung squamous cell carcinoma cell lines
Authors: Pan Lifang , Wu Qiong , Wang Yuqing , Ma Shenglin , Zhang Shirong 
Published: April 2023

AbstractBackgroundRadiotherapy is an important clinical treatment for patients with lung squamous cell carcinoma (LUSC), and resistance to radiotherapy is an important cause of recurrence and metastasis in LUSC. The aim of this study was to establish and explore the biological characteristics of radioresistant LUSC cells.Materials and methodsThe LUSC cell lines NCI‐H2170 and NCI‐H520 were irradiated (4 Gy × 15Fraction). Radiosensitivity, cell apoptosis, cell cycle, and DNA damage repair were measured by clonogenic survival assay, flow cytometry, immunofluorescence for γ‐H2AX foci, and Comet assay, respectively. Activation of p‐ATM(Ser1981), p‐CHK2(Th68), p‐DNA‐PKcs (Ser2056), and Ku70/Ku80 was measured by western blot. Proteomics was used to explore the differential genes and enriched signaling pathways between radioresistant cell lines and parental lines. In vivo nude mouse xenograft experiments further verified the feasibility of the radioresistant LUSC cell lines.ResultsAfter fractionated irradiation (total dose of 60 Gy), radioresistant cells had decreased radiosensitivity, increased G0/G1 phase arrest, enhanced DNA damage repair ability, and through the ATM/CHK2 and DNA‐PKcs/Ku70 pathways regulated double strands break. The upregulated differential genes in radioresistant cell lines were mainly enriched in biological pathways such as cell migration and extracellular matrix (ECM)‐receptor interaction. In vivo verification of decreased radiosensitivity of radioresistant cellsConclusionsRadioresistant LUSC cell lines were established by fractional radiotherapy, which regulates IR‐induced DNA damage repair through ATM/CHK2 and DNA‐PKcs/Ku70. Tandem Mass Tags (TMT) quantitative proteomics found that the biological process pathway of cell migration and ECM‐receptor interaction are upregulated in LUSC radioresistant cells.
Association between postoperative thrombocytopenia and outcomes after traumatic brain injury surgery: A cohort study
Authors: Xu Jianbo , Zhu Yanhong , Zhen Shuai , Jiang Xiaofeng 
Published: April 2023

AbstractBackgroundIt is well known that thrombocytopenia occurs in patients with traumatic brain injury (TBI), and its incidence increases with the severity of injury. We aimed to determine whether postoperative thrombocytopenia in patients with TBI is associated with poor clinical outcomes.MethodsThis was a retrospective cohort study of a large international database called the Medical Information Mart for Intensive Care III (MIMIC‐III), which included 1093 patients who underwent TBI surgery. Hospital mortality was the primary endpoint of this study.ResultsMultivariate logistic regression analysis revealed non‐thrombocytopenia was significantly associated with a decreased hospital mortality (adjusted odds ratio [OR] 0.49; 95% confidence interval [CI] 0.33–0.75; p = .01). In addition, platelet counts increased over time in both survivors and non‐survivors, according to generalized additive mixed model (GAMM). However, the platelet count increased more noticeably in the survivors than in the non‐survivors and the difference in platelet count between the two groups showed a trend toward increasing within 7 days after surgery. This difference increased by 7.97 per day on average.ConclusionsPatients with TBI who experienced postoperative thrombocytopenia were more likely to have a poor short‐term prognosis. In addition, we found that the rate of platelet growth over time varied significantly between the survival and non‐survival groups. Patients with TBI who experienced a greater early increase in platelet count had a lower mortality rate.
Parkin regulates microglial NLRP3 and represses neurodegeneration in Parkinson's disease
Authors: Yan Yi‐Qun , Zheng Ran , Liu Yi , Ruan Yang , Lin Zhi‐Hao , Xue Nai‐Jia , Chen Ying , Zhang Bao‐Rong , Pu Jia‐Li 
Published: April 2023

AbstractMicroglial hyperactivation of the NOD‐, LRR‐, and pyrin domain‐containing 3 (NLRP3) inflammasome contributes to the pathogenesis of Parkinson's disease (PD). Recently, neuronally expressed NLRP3 was demonstrated to be a Parkin polyubiquitination substrate and a driver of neurodegeneration in PD. However, the role of Parkin in NLRP3 inflammasome activation in microglia remains unclear. Thus, we aimed to investigate whether Parkin regulates NLRP3 in microglia. We investigated the role of Parkin in NLRP3 inflammasome activation through the overexpression of Parkin in BV2 microglial cells and knockout of Parkin in primary microglia after lipopolysaccharide (LPS) treatment. Immunoprecipitation experiments were conducted to quantify the ubiquitination levels of NLRP3 under various conditions and to assess the interaction between Parkin and NLRP3. In vivo experiments were conducted by administering intraperitoneal injections of LPS in wild‐type and Parkin knockout mice. The Rotarod test, pole test, and open field test were performed to evaluate motor functions. Immunofluorescence was performed for pathological detection of key proteins. Overexpression of Parkin mediated NLRP3 degradation via K48‐linked polyubiquitination in microglia. The loss of Parkin activity in LPS‐induced mice resulted in excessive microglial NLRP3 inflammasome assembly, facilitating motor impairment, and dopaminergic neuron loss in the substantia nigra. Accelerating Parkin‐induced NLRP3 degradation by administration of a heat shock protein (HSP90) inhibitor reduced the inflammatory response. Parkin regulates microglial NLRP3 inflammasome activation through polyubiquitination and alleviates neurodegeneration in PD. These results suggest that targeting Parkin‐mediated microglial NLRP3 inflammasome activity could be a potential therapeutic strategy for PD.
Investigating the relationship between early life adversity, inflammation and alcohol use
Authors: Battista Jillian T. , Piacentino Daria , Schwandt Melanie L. , Lee Mary R. , Faulkner Monica L. , Farokhnia Mehdi , Leggio Lorenzo 
Published: April 2023

AbstractEarly life adversity (ELA) has long‐lasting and potentially harmful effects on adult mental and physical health, including a higher likelihood of developing psychiatric conditions such as depression, anxiety and alcohol use disorder (AUD). It has been suggested that inflammation may play a role in linking ELA to the development of AUD. Here, we evaluated a number of predictive factors of high sensitivity C‐reactive protein (hsCRP), a key inflammatory marker, and the potential mediating role of hsCRP in the relationship between ELA and alcohol misuse in adulthood. Data was collected from participants who participated in NIAAA screening protocols between January 2013 and December 2019. In this secondary analysis, we first tested, via multiple linear regression, potential predictors of hsCRP levels among adults with AUD (N = 781) and non‐AUD (N = 440) individuals. We subsequently conducted mediation analyses to evaluate the potential role of hsCRP in the relationship between early life stress and alcohol use. Regression analysis showed that stress in early life, but not childhood trauma, significantly predicted increased hsCRP levels in adulthood (p < 0.05). Additionally, a greater amount of alcohol drinking, but not a diagnosis of AUD, significantly predicted increased hsCRP levels (p < 0.05). Furthermore, hsCRP mediated the relationship between early life stress and alcohol consumption. Early life stress and heavier alcohol drinking both predicted increased hsCRP levels; however, an AUD diagnosis did not. Elevated inflammation, due to and/or predicted by greater early life stress, may contribute to the development of unhealthy alcohol use in adulthood.
Predictive utility of the fetal cerebroplacental ratio for hypoxic ischaemic encephalopathy, severe neonatal morbidity and perinatal mortality in late‐preterm and term infants
Authors: Bendall Alexa , Schreiber Veronika , Crawford Kylie , Kumar Sailesh 
Published: April 2023

AimsThe aim of this study was to evaluate the association of a low cerebroplacental ratio (CPR) with hypoxic ischaemic encephalopathy (HIE), severe neonatal morbidity (SNM) and perinatal mortality (PNM).MethodsThis was a retrospective cohort study of late‐preterm and term births at Mater Mothers’ Hospital, Brisbane, between 2016 and 2020. Study outcomes were HIE, PNM and SNM (a composite of severe acidosis, Apgar score less than four at 5 min, severe respiratory distress or need for significant cardiopulmonary resuscitation at birth). Univariate and multivariable logistic regressions were used to determine if a low CPR was associated with HIE, SNM or PNM.ResultsA total of 51 870 births met the inclusion criteria. Of these, 216 (0.42%) were complicated by HIE, 10 224 (19.7%) had SNM and 251 (0.48%) had PNM. Rates of low CPR (<10th and <5th centile) were significantly higher in the SNM cohort (20.1 and 13.2%, respectively) and PNM cohort (21.1 and 15.1%, respectively) compared to the overall cohort. A low CPR was associated with significantly increased adjusted odds for SNM but not for HIE or PNM. The area under the receiver operating characteristic curve for CPR <10th centile was greatest for SNM (0.768) and lowest for HIE (0.595). Predictive margins of a low CPR for HIE, SNM and PNM were significant only for SNM at late‐preterm gestations.ConclusionsA low CPR is associated with increased odds of SNM in infants born >34 weeks’ gestation but not for HIE or PNM.
Prenatal maternal stress was not associated with birthweight or gestational age at birth during COVID‐19 restrictions in Australia: The BITTOC longitudinal cohort study
Authors: Gladstone Miriam E. , Paquin Vincent , McLean Mia A. , Lequertier Belinda , Elgbeili Guillaume , Kildea Sue , Klimos Chloe , King Suzanne , Dahlen Hannah G. 
Published: April 2023

ABSTRACTBackgroundVarious forms of prenatal maternal stress (PNMS) have been reported to increase risk for preterm birth and low birthweight. However, the associations between specific components of stress – namely objective hardship and subjective distress ‐ and birth outcomes are not well understood.AimsHere, we aimed to determine the relationship between birthweight and gestational age at birth and specific prenatal factors (infant gender and COVID‐19 pandemic‐related objective hardship, subjective distress, change in diet), and to determine whether effects of hardship are moderated by maternal subjective distress, change in diet, or infant gender.Materials and methodsAs part of the Birth in the Time of COVID (BITTOC study), women (N = 2285) who delivered in Australia during the pandemic were recruited online between August 2020 and February 2021. We assessed objective hardship and subjective distress related to the COVID pandemic and restrictions, and birth outcomes through questionnaires that were completed at recruitment and two months post‐partum. Analyses included hierarchical multiple regressions.ResultsNo associations between maternal objective hardship or subjective distress and gestational age at birth or birthweight were identified. Lower birthweight was significantly associated with female gender (adjusted β = 0.083, P < 0.001) and with self‐reported improvement in maternal diet (adjusted β = 0.059, P = 0.015).ConclusionsIn a socioeconomically advantaged sample, neither objective hardship nor subjective distress related to COVID‐19 were associated with birth outcomes. Further research is warranted to understand how other individual factors influence susceptibility to PNMS and how these findings are applicable to women with lower socioeconomic status.
The first Australian uterus transplantation procedure: A result of a long‐term Australian‐Swedish research collaboration
Authors: Deans Rebecca , Pittman Jana , Gerstl Brigitte , Haghighi Koroush , Pleass Henry , KÄhler Pernilla Dahm , Kvarnström Niclas , Hseuh Wayne , Keung Karen , Luxton Grant , Yong Kenneth , Caldas Rita , Byun Lily , Loo Christine , Tippett John , Caponas George , Moses Daniel , Wan King‐Man , Arulpragasam Kaushalya , Kiely Neill , Brännström Mats , Abbott Jason 
Published: April 2023

AimsThe aim is to report the results of Australia's first uterus transplantation (UTx).MethodsFollowing long‐standing collaboration between the Swedish and Australian teams, Human Research Ethics approval was obtained to perform six UTx procedures in a collaborative multi‐site research study (Western Sydney Local District Health 2019/ETH13038), including Royal Hospital for Women, Prince of Wales Hospital, and Westmead Hospital in New Souh Wales. Surgeries were approved in both the live donor (LD) and deceased donor models in collaboration with the inaugural Swedish UTx team.ResultsThis is the first UTx procedure to occur in Australia, involving a mother donating her uterus to her daughter. The total operative time for the donor was 9 h 54 min. Concurrently, recipient surgery was synchronised to minimise graft ischaemic time, and the total operative time for the recipient was 6 h 12 min. Surgery was by laparotomy in the LD and recipient. The total warm ischaemic time of the graft was 1 h 53 min, and the cold ischaemic time was 2 h 17 min (total ischaemic time 4 h 10 min). The patient's first menstruation occurred 33 days after the UTx procedure.ConclusionTwenty‐five years of Swedish and Australian collaboration has led to Australia's first successfully performed UTx surgery at The Royal Hospital for Women, Sydney, Australia.
Moving materialities: Oceanic epistemologies and embodied knowledge production in Pentecostal women's health mentorship in Samoa
Authors: Hardin Jessica 
Published: April 2023

AbstractThis article employs Oceanic epistemological theories to explore the body as a site of knowledge production among Samoan Pentecostal women as they dance in a church‐sponsored Zumba session, tracking foods, words, and feelings: I call thesemoving materialities. In their work together, these women contextualized health, sickness, and weight as generated from the circulation of these kinds of moving materialities. Their work theorizing health through material change is quite different from those imagined and circulated in the literatures on diabetes and obesity. The article orients critical studies of health toward an interrogation of the dynamic qualities of materiality, including both the moving body and materials that move between or within bodies. By expanding what might be considered material and movement in the context of health, this article offers an alternative to theories of metabolism that have come to dominate how we understand the body in terms energy expenditure. Ultimately, this approach calls for anthropologists to consider the circumstances in which theory is understood to be “culturally specific” or “generalizable.”
Intraoperative use of tranexamic acid to reduce blood loss during cytoreductive surgery for advanced ovarian cancer: A randomized controlled clinical trial
Authors: Yang Xijun , Chai Mao , Xia Lingfang , He Zhiyong , Wu Xiaohua , Zhang Jun 
Published: April 2023

AbstractIntroductionTranexamic acid reduces blood loss and allogeneic transfusion requirements in various surgical procedures. The role of tranexamic acid during cytoreductive procedures in advanced ovarian cancer is not clear.Material and methodsThis was a single center randomized, controlled, three‐armed clinical trial. A total of 150 ovarian cancer patients undergoing cytoreductive surgery were recruited and assigned to three groups (n = 50/group): the control group (normal saline), low‐dose group (10 mg/kg bolus + 1 mg/kg continuous infusion of tranexamic acid), and high‐dose group (20 mg/kg bolus + 5 mg/kg continuous infusion of tranexamic acid). The primary endpoint was intraoperative blood loss volume and total blood loss volume, and secondary endpoints included intraoperative blood transfusion volumes, vasoactive agent consumption, admission into the intensive care unit, and incidence of postoperative complications within postoperative 30 days. The study was registered at ClinicalTrials.gov ID: NCT04360629.ResultsThe patients in the high‐dose group had less intraoperative (median [IQR]: 625.3 mL [343.5–1210.5]) and total blood loss volume (748.9 mL [292.2–1650.2]) than those in the control group (1015.5 mL [679.4–1015.5], p = 0.012; and 1700.7 mL [458.7–2419.8], p = 0.004, respectively). In contrast, the intraoperative (992.5 mL [539.0–1404.0], p = 0.874) and total blood loss volume (1025.0 mL [381.8–1819.9], p = 0.113) was not significantly reduced in the low‐dose group when compared with the control group. Correspondingly, the relative risk of blood transfusion (RR [95% CI], 0.405 [0.180–0.909], p = 0.028) was reduced in the high‐dose group and required less intraoperative noradrenaline (881.0 ± 438.3 mg) to maintain stable hemodynamics than the control group (1548.0 ± 349.8 mg, p = 0.001). Furthermore, compared with the control group, the two tranexamic acid groups had decreased intensive care unit admission rates (p = 0.016) without increasing the incidence of postoperative seizure, acute kidney injury, and thromboembolism.ConclusionsHigh‐dose tranexamic acid is more effective in reducing blood loss and blood transfusion without increasing the risk of postoperative complications. The high‐dose regime tended to have a better risk–benefit profile.
The culture of perceptual expertise and the other‐race effect
Authors: Lall Megan K. , Tanaka James W. 
Published: April 2023

AbstractIn our commentary, we propose that the ORE can be viewed as a form of perceptual expertise. Like experts, we recognize own‐race faces at the subordinate level as individuals and novices when recognize other‐race faces at the basic level of race. Applying a perceptual expertise account, we explain the ORE in terms of its cognitive, neural, and motivational factors. We suggest that by creating a culture of “other‐race” expertise, improvements in other‐race face recognition can be achieved.
Silicon switch: Carbon–silicon Bioisosteric replacement as a strategy to modulate the selectivity, physicochemical, and drug‐like properties in anticancer pharmacophores
Authors: Fotie Jean , Matherne Caitlyn M. , Wroblewski Jordan E. 
Published: April 2023

AbstractBioisosterism is one of the leading strategies in medicinal chemistry for the design and modification of drugs, consisting in replacing an atom or a substituent with a different atom or a group with similar chemical properties and an inherent biocompatibility. The objective of such an exercise is to produce a diversity of molecules with similar behavior while enhancing the desire biological and pharmacological properties, without inducing significant changes to the chemical framework. In drug discovery and development, the optimization of the absorption, distribution, metabolism, elimination, and toxicity (ADMETox) profile is of paramount importance. Silicon appears to be the right choice as a carbon isostere because they possess very similar intrinsic properties. However, the replacement of a carbon by a silicon atom in pharmaceuticals has proven to result in improved efficacy and selectivity, while enhancing physicochemical properties and bioavailability. The current review discusses how silicon has been strategically introduced to modulate drug‐like properties of anticancer agents, from a molecular design strategy, biological activity, computational modeling, and structure–activity relationships perspectives.