bluuebunny/crossref_metadata_2025_split huggingface dataset:
The association between the number of symptoms and the severity of Post-COVID-Fatigue after SARS-CoV-2 infection treated in an outpatient setting
Authors: Schmidbauer Lena , Kirchberger Inge , Goßlau Yvonne , Warm Tobias D. , Hyhlik-Dürr Alexander , Linseisen Jakob , Meisinger Christa 
Published: May 2023

Abstract
Background
Post-COVID-Fatigue (PCF) is one of the most reported symptoms following SARS-CoV-2 infection. Currently, research on persistent symptoms focuses mainly on severe infections, while outpatients are rarely included in observations.

Objective
To investigate whether the severity of PCF is related to the number of acute and persistent symptoms due to mild-to-moderate COVID-19 and to compare the most common symptoms during acute infection with the persistent symptoms in PCF patients.

Methods
A total of 425 participants were examined after COVID-19 treated as an outpatient (median 249 days [IQR: 135; 322] after acute disease) at the site of University Hospital Augsburg, Germany. The Fatigue Assessment Scale (FAS) was used to quantify the severity of PCF. The number of symptoms (maximum 41) during acute infection and persistent symptoms (during the last 14 days before examination) were added up to sum scores. Multivariable linear regression models were used to show the association between the number of symptoms and PCF.

Results
Of the 425 participants, 37% (n = 157) developed PCF; most were women (70%). The median number of symptoms was significantly higher in the PCF group than in the non-PCF group at both time points. In multivariable linear regression models, both sum scores were associated with PCF (acute symptoms: β-estimate per additional symptom [95%-CI]: 0.48 [0.39; 0.57], p < 0.0001); persistent symptoms: β-estimate per additional symptom [95%-CI]: 1.18 [1.02; 1.34], p < 0.0001). The acute symptoms strongest associated with PCF severity were difficulty concentrating, memory problems, dyspnea or shortness of breath on exertion, palpitations, and problems with movement coordination.

Conclusion
Each additional symptom that occurs in COVID-19 increases the likelihood of suffering a higher severity of PCF. Further research is needed to identify the aetiology of PCF.
Trial registration: Nr. NCT04615026. Date of registration: November 4, 2020.
The effects of transitioning from immediate release to extended release cysteamine therapy in Norwegian patients with nephropathic cystinosis: a retrospective study
Authors: Bjerre Anna , Aase Sonja Amdal , Radtke Maria , Siva Christian , Gudmundsdottir Helga , Forsberg Brita , Woldseth Berit , Brackman Damien 
Published: May 2023

Abstract

Background
Nephropathic cystinosis is a rare lysosomal storage disorder in which accumulation of cystine and formation of crystals particularly impair kidney function and gradually lead to multi-organ dysfunction. Lifelong therapy with the aminothiol cysteamine can delay the development of kidney failure and the need for transplant. The purpose of our long-term study was to explore the effects of transitioning from immediate release (IR) to extended release (ER) formulation in Norwegian patients in routine clinical care.

Methods
We retrospectively analysed data on efficacy and safety in 10 paediatric and adult patients. Data were obtained from up to 6 years before and 6 years after transitioning from IR- to ER-cysteamine.

Results
Mean white blood cell (WBC) cystine levels remained comparable between the different treatment periods (1.19 versus 1.38 nmol hemicystine/mg protein) although most patients under ER-cysteamine underwent dose reductions. For the non-transplanted patients, the mean estimated glomerular filtration rate (eGFR) change/year was more pronounced during ER-treatment (− 3.39 versus − 6.80 ml/min/1.73 m2/year) possibly influenced by individual events, such as tubulointerstitial nephritis and colitis. Growth measured by Z-height score tended to develop positively. Four of seven patients reported improvement of halitosis, one reported unchanged and two reported worsened symptoms. Most adverse drug reactions (ADRs) were of mild severity. One patient developed two serious ADRs and switched back to IR-formulation.

Conclusions
The results from this long-term retrospective study indicate that switching from IR- to ER-cysteamine was feasible and well tolerated under routine clinical practice. ER-cysteamine allowed satisfactory disease control over the long period considered.

Graphical abstract
An interdisciplinary educational path to understand the economic phenomena of a fluid and complex world with mathematics
Authors: Bimonte Giovanna , Tortoriello Francesco Saverio , Veronesi Ilaria 
Published: May 2023

AbstractIn this paper, we describe an activity that involves economics and mathematics. It is included in the planning of orientation paths towards university studies within the Mathematical High School Project and is dedicated to students in the last years of high school. In particular, this research will deal with the issue of solving an economic problem using not only real analysis instruments but also geometrical topics concerning Euclidean geometry and topology. Mathematics becomes a language to understand and explain a real life problem, such as determining the optimal position of an airport, a nuclear reactor and so on. Some activities made use of dynamic geometry software and computer simulations.
Sessile serrated lesions with dysplasia: is it possible to nip them in the bud?
Authors: Utsumi Takahiro , Yamada Yosuke , Diaz-Meco Maria Teresa , Moscat Jorge , Nakanishi Yuki 
Published: May 2023

AbstractThe serrated neoplasia pathway constitutes an “alternative route” to colorectal cancer (CRC), and sessile serrated lesions with dysplasia (SSLDs) are an intermediate step between sessile serrated lesions (SSLs) and invasive CRC in this pathway. While SSLs show indolent growth before becoming dysplastic (> 10–15 years), SSLDs are considered to rapidly progress to either immunogenic microsatellite instable-high (MSI-H) CRC (presumably 75% of cases) or mesenchymal microsatellite stable (MSS) CRC. Their flat shapes and the relatively short window of this intermediate state make it difficult to detect and diagnose SSLDs; thus, these lesions are potent precursors of post-colonoscopy/interval cancers. Confusing terminology and the lack of longitudinal observation data of serrated polyps have hampered the accumulation of knowledge about SSLDs; however, a growing body of evidence has started to clarify their characteristics and biology. Together with recent efforts to incorporate terminology, histological studies of SSLDs have identified distinct dysplastic patterns and revealed alterations in the tumor microenvironment (TME). Molecular studies at the single-cell level have identified distinct gene alterations in both the epithelium and the TME. Mouse serrated tumor models have demonstrated the importance of TME in disease progression. Advances in colonoscopy provide clues to distinguish pre-malignant from non-malignant-SSLs. Recent progress in all aspects of the field has enhanced our understanding of the biology of SSLDs. The aim of this review article was to assess the current knowledge of SSLDs and highlight their clinical implications.
Stabilization estimates for the Brinkman–Forchheimer–Kelvin–Voigt equation backward in time
Authors: Gentile Maurizio , Straughan Brian 
Published: May 2023

AbstractThe final value value problem for the Brinkman–Forchheimer–Kelvin–Voigt equations is analysed for quadratic and cubic types of Forchheimer nonlinearity. The main term in the Forchheimer equations is allowed to be fully anisotropic. It is shown that the solution depends continuously on the final data provided the solution satisfies an a priori bound in $$L^3.$$

L
3

.

The technique employed avoids the use of a specialist method for an improperly posed problem such as logarithmic convexity.
Localized conditional induction of brain arteriovenous malformations in a mouse model of hereditary hemorrhagic telangiectasia
Authors: Scherschinski Lea , Han Chul , Kim Yong Hwan , Winkler Ethan A. , Catapano Joshua S. , Schriber Tyler D. , Vajkoczy Peter , Lawton Michael T. , Oh S. Paul 
Published: May 2023

Abstract
Background
Longitudinal mouse models of brain arteriovenous malformations (AVMs) are crucial for developing novel therapeutics and pathobiological mechanism discovery underlying brain AVM progression and rupture. The sustainability of existing mouse models is limited by ubiquitous Cre activation, which is associated with lethal hemorrhages resulting from AVM formation in visceral organs. To overcome this condition, we developed a novel experimental mouse model of hereditary hemorrhagic telangiectasia (HHT) with CreER-mediated specific, localized induction of brain AVMs.

Methods
Hydroxytamoxifen (4-OHT) was stereotactically delivered into the striatum, parietal cortex, or cerebellum of R26CreER; Alk12f/2f (Alk1-iKO) littermates. Mice were evaluated for vascular malformations with latex dye perfusion and 3D time-of-flight magnetic resonance angiography (MRA). Immunofluorescence and Prussian blue staining were performed for vascular lesion characterization.

Results
Our model produced two types of brain vascular malformations, including nidal AVMs (88%, 38/43) and arteriovenous fistulas (12%, 5/43), with an overall frequency of 73% (43/59). By performing stereotaxic injection of 4-OHT targeting different brain regions, Alk1-iKO mice developed vascular malformations in the striatum (73%, 22/30), in the parietal cortex (76%, 13/17), and in the cerebellum (67%, 8/12). Identical application of the stereotaxic injection protocol in reporter mice confirmed localized Cre activity near the injection site. The 4-week mortality was 3% (2/61). Seven mice were studied longitudinally for a mean (SD; range) duration of 7.2 (3; 2.3−9.5) months and demonstrated nidal stability on sequential MRA. The brain AVMs displayed microhemorrhages and diffuse immune cell invasion.

Conclusions
We present the first HHT mouse model of brain AVMs that produces localized AVMs in the brain. The mouse lesions closely resemble the human lesions for complex nidal angioarchitecture, arteriovenous shunts, microhemorrhages, and inflammation. The model’s longitudinal robustness is a powerful discovery resource to advance our pathomechanistic understanding of brain AVMs and identify novel therapeutic targets.
Doing well by doing good: unpacking the black box of corporate social responsibility
Authors: Xia Li , Li Zhi , Wei Jiuchang , Gao Shuo 
Published: May 2023

AbstractBusinesses worldwide have increasingly embraced the corporate social responsibility (CSR) concept in their operations, and hence the popular saying ‘doing well by doing good’. Previous literature has not yet reached a consensus on the nature of the relationship between CSR and corporate financial performance (CFP). To contribute to the resolution of the issue, this article examines the relationship through evidence from China’s renewable energy enterprises. To evaluate the effect of CSR on CFP, this study takes CSR as a construct that consists of corporate responsibilities for (i) shareholders, (ii) employees, (iii) customers, suppliers, and consumers, (iv) the natural environment, and (v) social contributions. Based on data of the listed firms in China’s renewable energy from 2010 to 2016, this study shows that overall CSR can enhance CFP. For China’s renewable energy industry, shareholder and environmental dimensions of CSR positively affect CFP, while the responsibility for non-shareholder stakeholders, particularly for customers, suppliers and consumers, demonstrates a negative effect. No significant effect is identified between the responsibility for social contributions and CFP, and neither is between employee responsibility and CFP.
Molecular characterization of Aureobasidium spp. strains isolated during the cold season. A preliminary efficacy evaluation as novel potential biocontrol agents against postharvest pathogens
Authors: Cignola R. , Boato A. , Sadallah A. , Firrao G. , Di Francesco A. 
Published: May 2023

AbstractSeveral Aureobasidium spp. strains isolated from wild environments during winter 2022 were characterized by sequence analysis of the internal transcribed spacer (ITS), the translation elongation factor EF-1α gene (EF1), and part of the elongase gene (ELO). The variability in the EF1 and ELO loci are higher than in the ITS. All strains but one (UC14), were identified as A. pullulans. To assess the effectiveness of the characterized strains as biocontrol agents (BCAs) of diseases occurring during postharvest storage, a selection of the strains was evaluated by in vitro and in vivo assays. On average, the reduction of Monilinia spp. colony growth was more marked for non-volatile metabolites than for volatile (VOCs). Strain UC14 provided the strongest mycelial growth reduction of Monilinia fructicola by VOCs (66%). According to the in vivo results, all strains were effective in controlling brown rot during cold storage and remarkably in restricting the growth of Monilinia polystroma. In particular, VB23 was the most effective in controlling brown rot incidence, by 80%, 60%, 100%, and severity, by 79.5%, 72.7% and 100%, for Monilinia laxa, M. fructicola, and M. polystroma, respectively.
Co-producing uncomfortable, transdisciplinary, actionable knowledges against the corporate food regime through critical science approaches
Authors: Orozco-Meléndez José Francisco , Paneque-Gálvez Jaime 
Published: May 2023

AbstractThe current corporate food regime generates some of the most challenging ecological, social, and ethical problems for humanity in its quest for sustainability and ecological justice. Different scientific disciplines have analyzed these problems in-depth, but usually from their comfort zone, i.e., without engagement with other disciplines and epistemologies. The predominance of disciplinary visions seriously limits, however, understanding the complexities of the corporate food regime, including the impacts it generates. Further, most research concerned with this food regime confronts epistemological, methodological, and political limitations to engage with the type of solutions that could lead to transitions to just sustainabilities. Here we review and integrate the findings from scientific literature focused on the ecological, social, or ethical impacts of the corporate food regime, with an emphasis on impacts that operate on a global scale. In addition, we analyze the need for critical science approaches to trigger generative processes for the co-production of uncomfortable, transdisciplinary, actionable knowledges that are fit for designing just and sustainable food regimes. Much of the evidence presented in our analysis is in tension with the interests of the corporate food regime, which fosters decision-making processes based on selective ignorance of the impacts caused by this regime. Our work provides arguments that justify the need to promote transitions to just sustainabilities in agricultural systems from multiple domains (e.g., research and development, public policies, grassroots innovations). We posit that strategies to co-design and build such transitions can emerge from the co-production of uncomfortable, transdisciplinary, actionable knowledges through critical science approaches.
Support in Daily Living for Young Adults with Neurodevelopmental Conditions in Sweden: A Qualitative Description of Current Practice
Authors: Löthberg Maria , Hirvikoski Tatja , Girdler Sonya , Bölte Sven , Jonsson Ulf 
Published: May 2023

AbstractIn Sweden, people living independently and requiring daily living support can access ‘housing support’, a form of practical, educational, and social support provided by the municipalities. About two-thirds of those receiving this support have neurodevelopmental conditions, primarily autism or ADHD. Many are young adults in the process of adapting to new roles and expectations in different life domains, including education, work, and accommodation. This study aimed to provide a qualitative description of support workers’ views on current practice in housing support for young adults (aged 18 to 29) with neurodevelopmental conditions. Semi-structured telephone interviews were conducted with 34 housing support workers across 19 Swedish regions. An inductive qualitative content analysis approach was used. The interviews depicted a complex service, subject to organizational aspects (roles, responsibilities, availability, and allocation), the joint effort of key players (young adults, relatives, and support workers), and practical aspects of service provision (finding common ground for the work, and delivery of support). Some elements of the service were poorly designed for the target group. The support workers expressed a need for more knowledge about neurodevelopmental conditions, but also described new insights related to remote delivery of support. The results raise important questions about how housing support should be organized and delivered to strike the right balance between support and autonomy, meet specific needs, and ensure equal services across municipalities. Future research should adopt multiple perspectives and approaches, to help translate best practice and available evidence into a flexible and sustainable service.
Niche Construction and Long-Term Trajectories of Food Production
Authors: Quintus Seth , Allen Melinda S. 
Published: May 2023

AbstractNiche construction theory has played a prominent role in archaeology during the last decade. However, the potential of niche construction in relation to agricultural development has received less attention. To this end, we bring together literature on the forms and sources of agronomic variability and use a series of examples to highlight the importance of reciprocal causation and ecological inheritance in trajectories of agricultural change. We demonstrate how niche construction theory can inform on emergent mutualisms in both inceptive and established agronomic contexts, the recursive relationships between humans and their agronomic environments, and bridges between the past and present.
Perceived Anti-Immigrant Climate, Health Care Discrimination, and Satisfaction with Care Among US Latino Adults
Authors: López-Cevallos Daniel F. , Vargas Edward D. , Sanchez Gabriel R. 
Published: May 2023

AbstractA growing body of evidence has documented the effects of discrimination among Latinos. However, little is known about the impacts a noxious sociopolitical climate can have on their health and health care outcomes. The present study explored the associations between perceived anti-immigrant climate, health care discrimination, and satisfaction with care among US Latino adults. We used data from the 2015 Latino National Health and Immigration Survey (n = 1,284), a nationally representative sample of US Latino adults (ages 18 and older). Key predictors included living in a state whose policies are unfavorable towards immigrants, perceived anti-immigrant climate and/or anti-Hispanic climate, and health care discrimination. Ordered logistic regression models evaluated the associations between these predictors (adjusting for other relevant covariates) and satisfaction with care. Latinos living in state that is unfavorable towards immigrants were less likely to be satisfied with medical care they receive. Also, we found that Latinos living in anti-immigrant and anti-Hispanic climates were less likely to be satisfied with care. In both cases, experiencing health care discrimination significantly reduced the odds of satisfaction with care. Latinos’ perception of an anti-immigrant & anti-Hispanic climate and state policies can have detrimental effects on their health and health care outcomes. These results highlight the importance of addressing both community-wide and interpersonal discrimination specific to health care settings, which can have concurrent impacts on the health and well-being of Latino and other minoritized populations.
The size of human subcutaneous adipocytes, but not adiposity, is associated with inflammation, endoplasmic reticulum stress, and insulin resistance markers
Authors: Pourdashti Sara , Faridi Nassim , Monem-Homaie Forouzandeh , Yaghooti S. Hamid , Soroush Ahmadreza , Bathaie S. Zahra 
Published: May 2023

Abstract
Background
The fat storage capacity of the adipose tissue prevents ectopic lipid deposition, which is one of the risk factors for metabolic abnormalities in obesity. This capacity depends upon the adipogenic gene expression and blood supply provision for tissue expansion through angiogenesis. Here, we studied hyperplasia/hypertrophy of subcutaneous white adipose tissue (scWAT) concerning adipogenic gene expression, angiogenic status, and metabolic parameters in non-obese and different classes of obese individuals.

Methods
The scWAT samples were collected from 80 individuals. The anthropometric parameters, adipose tissue cell size, serum biochemistry, ER stress-induced XBP1 splicing, PPARγ2, SFRP1, WNT10B, and VEGFA gene expression levels were studied. In addition, the CD31 level was investigated by Western blotting.

Results
The obese individuals had greater waist circumferences and higher serum TG, TC, insulin, and HOMA-IR than the non-obese group. However, the largest adipocyte size, increased TNFα, insulin, and HOMA-IR, and the highest expression level of sXBP1, WNT10B, and VEGFA were observed in Class I obese individuals. It means that inflammation, insulin resistance, and ER stress accompany hypertrophic scWAT adipocytes with limited adipose tissue expansion ability. Furthermore, the Class II + III obese individuals showed high PPARγ2 expression and CD31 levels. There is adipogenesis through hyperplasia in this group. The SFRP1 expression was not significantly different in the studied groups.

Conclusion
The results suggest that the capability of adipogenesis with inadequate angiogenesis is related to the metabolic status, inflammation, and ER function. Therefore, therapeutic strategies that support both angiogenesis and adipogenesis can effectively prevent the complications of obesity.
Derivation of a superelement with deformable interfaces – applied to model flexure joint
Authors: Dwarshuis Koen , Ellenbroek Marcel , Aarts Ronald , Brouwer Dannis 
Published: May 2023

AbstractDesign and optimization, as well as real time control, of flexure mechanisms require efficient but accurate models. The flexures can be modelled using beam elements and the frame parts can be modelled using superelements. Such a superelement efficiently models arbitrarily shaped bodies by few coordinates, using models obtained by model order reduction. The interfaces between the frame parts and the flexures often experience considerable deformation which affects the stiffness. To define the interface deformation in a reduced order model, this paper derives a multipoint constraint formulation, which relates the nodes on the deformable interface surface of a finite element model to a few coordinates. The multipoint constraints are imposed using a combination of the Lagrange multiplier method and master–slave elimination for efficient model order reduction. The resulting reduced order models are used in the generalized-strain multi-node superelement (GMS) that was defined in (Dwarshuis et al. in Multibody Syst. Dyn. 56(4):367–399, 2022). The interface deformations can be coupled to the cross-sectional deformation of higher order beam elements (i.e. beam elements of which the deformation of the cross-sections is explicitly taken into account).This paper applies this technique to model flexure joints, where the flexures are modelled with beam elements, and the frame components and critical connections using the GMS. This approach gives generally over 94% accurate stiffness, compared to nonlinear finite element models. The errors were often more than 50% lower than errors of models which only contain beam elements.