bluuebunny/crossref_metadata_2025_split huggingface dataset:
A place with a view: A first‐person perspective in the hippocampal memory space
Authors: Wirth Sylvia 
Published: April 2023

AbstractHow do rodents' and primates' differences in visual perception impact the way the brain constructs egocentric and allocentric reference frames to represent stimuli in space? Strikingly, there are important similarities in the egocentric spatial reference frames through which cortical regions represent objects with respect to an animal's head or body in rodents and primates. These egocentric representations are suitable for navigation across species. However, while the rodent hippocampus represents allocentric place, I draw on several pieces of evidence suggesting that an egocentric reference frame is paramount in the primate hippocampus, and relates to the first‐person perspective characteristic of a primate's field of view. I further discuss the link between an allocentric reference frame and a conceptual frame to suggest that an allocentric reference frame is a semantic construct in primates. Finally, I discuss how views probe memory recall and support prospective coding, and as they are based on a first‐person perspective, are a powerful tool for probing episodic memory across species.
Development and validation of a new antenatal warning score system (DRRiP) for neonatal complications of gestational diabetes
Authors: Mukherjee Gargi , Zhang Jufen , Banerjee Indranil , Mannan Shaheen , Ikomi Amaju 
Published: April 2023

AbstractObjectiveTo evaluate the DRRiP (Diabetes Related Risk in Pregnancy) score warning system as a tool for predicting neonatal morbidity in gestational diabetes.MethodsA retrospective observational cohort study. By applying nine parameters from an antenatal trichotomy of glycemic, ultrasound, and clinical characteristics, DRRiP scores were calculated and assigned to each patient using a checklist tool. Logistic regression models were used to evaluate the association between DRRiP score and adverse fetal outcomes, after adjusting for maternal age and body mass index (calculated as weight in kilograms divided by the square of height in meters).ResultsIn all, 627 women were studied. DRRiP score was an excellent predictor of macrosomia and shoulder dystocia (both areas under the receiver operating characteristics curves [AUROC] = 0.86), and a modest predictor of preterm delivery, hyperbilirubinemia, neonatal intensive care unit admission and a composite of either of the studied events (AUROC range 0.63–0.69). For the composite outcome, the sensitivity of an amber trigger score of 1 was 68.7% (95% confidence interval [CI] 62.27%–74.63%) and specificity was 48.87% (95% CI 43.85%–53.9%). Specificity at a red trigger score of 3 (89.7%) and a graded increase in post‐test probability (90.7% risk at a score of 5) were highly encouraging.ConclusionDRRiP score offers reasonable discriminative performance that could be clinically useful for meaningful risk stratification when making delivery plans.
Bisphenol A aggravate selenium deficiency‐induced apoptosis via miR‐215‐3p/Dio1 to activate ROS/PI3K/AKT pathway in chicken arterial
Authors: Li Zhe , Xu Tong , Fan Xue , Chen Kai , Wan Chunyan , Li Xiang , Yin Hang , Li Shu 
Published: April 2023

AbstractBoth bisphenol A (BPA) and selenium (Se) deficiency can affect the expression of microRNAs (miRNAs), which can specifically regulate its target mRNA and induce apoptosis, and play a significant role in cardiovascular injury diseases. To explore the mechanism of apoptosis induced by BPA and Se deficiency in chicken arterial endothelial tissue and the role of miRNAs in this process, the model of BPA exposure/Se deficiency in chicken and PAEC cells have been employed. The targeting relationship between miR‐215‐3p and iodothyronine deiodinase 1 (Dio1) in PAEC was verified by double luciferase gene report. The level of miR‐215‐3p was detected by qRT‐PCR. The oxidative stress level of arterial endothelial cells was detected by oxidative stress kit and DCFH‐DA probe method. The PI3K/AKT pathway, mitochondrial dynamics, and apoptosis‐related genes were detected by qRT‐PCR and western blot. The mitochondrial ATP level and nitric oxide synthases (NOSs) level were detected with the kit. TUNEL, acridine orange/ethidium bromide, and flow cytometry were used to detect the level of apoptosis. The results showed that BPA exposure and Se deficiency led to overexpression of miR‐215‐3p, aggravated oxidative stress, inhibited activation of PI3K/AKT pathway, promoted mitochondrial division, increased expression of apoptosis related genes, and finally led to apoptosis of chicken arterial endothelial cells. We also established knockdown/overexpression models of miR‐215‐3p and Dio1 in vitro, and found that overexpression of miR‐215‐3p and knockout of Dio1 can induce apoptosis. Interestingly, miR‐215‐3p‐Inhibitor and N‐acetyl‐
l‐cysteine (NAC) partially prevented apoptosis caused by BPA exposure and Se deficiency, and LY294002 aggravated apoptosis. These results suggest that BPA exposure aggravates the apoptosis of Se deficient arterial endothelial cells in chickens by regulating the ROS/PI3K/AKT pathway activated by miR‐215‐3p/Dio1. The miR‐215‐3p/Dio1 axis provides a new way to understand the toxic mechanism of BPA exposure and Se deficiency, and reveals a new regulatory model of apoptosis damage in vascular diseases.
Terrestrial Zen master: Transcriptomics in long‐term aestivation and arousal of Mediterranean earthworms
Authors: Tilikj Natasha , Martínez Navarro Alejandro , Novo Marta 
Published: April 2023

AbstractEarthworms have a crucial role in the maintenance of the biotic and abiotic soil properties, which is important for the biodiversity and productivity of terrestrial ecosystems, especially in the current scenario of climate change. Aestivation is a form of dormancy witnessed in organisms living in deserts or semiarid environments such as the ones found in the central part of the Iberian Peninsula. This work employs next‐generation sequencing techniques to explore the changes in gene expression of different aestivation times (1 month and 1 year) as well as changes in gene expression upon arousal. Not surprisingly, the more the aestivation persisted the higher levels of gene downregulation were observed. Conversely, upon arousal, a quick recovery of the levels of gene expression were noted, comparable to the control. Transcriptional changes related to immune responses coming predominantly from abiotic stressors in aestivating earthworms and from biotic stressors in aroused earthworms triggered regulation of the cell fate via apoptosis. Long‐term aestivation seemed to be enabled by remodeling of the extracellular matrix, activity of DNA repair mechanisms, and inhibitory neurotransmitters, which could also play a role in lifespan increase. Arousal from 1‐month aestivation was on the other hand, characterized by regulation of the cell division cycle. Since aestivation is considered as an unfavorable metabolic state, aroused earthworms probably go through a damage removal process and a subsequent reparation process. This study provides the first transcriptomic investigation done on earthworms in such long aestivation times as well as arousal demonstrating the resilience and adaptability of Carpetania matritensis.
Modelling the impact and cost‐effectiveness of non‐governmental organizations on HIV and HCV transmission among people who inject drugs in Ukraine
Authors: Stone Jack , Trickey Adam , Walker Josephine G. , Bivegete Sandra , Semchuk Nadiya , Sazonova Yana , Varetska Olga , Altice Frederick L. , Saliuk Tetiana , Vickerman Peter 
Published: April 2023

AbstractIntroductionPeople who inject drugs (PWID) in Ukraine have high prevalences of HIV and hepatitis C virus (HCV). Non‐governmental organizations (NGOs) provide PWID with needles/syringes, condoms, HIV/HCV testing and linkage to opioid agonist treatment (OAT) and antiretroviral therapy (ART). We estimated their impact and cost‐effectiveness among PWID.MethodsA dynamic HIV and HCV transmission model among PWID was calibrated using data from four national PWID surveys (2011–2017). The model assumed 37–49% coverage of NGOs among community PWID, with NGO contact reducing injecting risk and increasing condom use and recruitment onto OAT and ART. We estimated the historic (1997–2021) and future (2022–2030, compared to no NGO activities from 2022) impact of NGOs in terms of the proportion of HIV/HCV infections averted and changes in HIV/HCV incidence. We estimated the future impact of scaling‐up NGOs to 80% coverage with/without scale‐up in OAT (5–20%) and ART (64–81%). We estimated the cost per disability‐adjusted life‐year (DALY) averted of current NGO provision over 2022–2041 compared to NGO activities stopping over 2022–2026, but restarting after that till 2041. We assumed average unit costs of US$80–90 per person‐year of NGO contact for PWID.ResultsWith existing coverage levels of NGOs, the model projects that NGOs have averted 20.0% (95% credibility interval: 13.3–26.1) and 9.6% (5.1–14.1) of new HIV and HCV infections among PWID over 1997–2021, respectively, and will avert 31.8% (19.6–39.9) and 13.7% (7.5–18.1) of HIV and HCV infections over 2022–2030. With NGO scale‐up, HIV and HCV incidence will decrease by 54.2% (43.3–63.8) and 30.2% (20.5–36.2) over 2022–2030, or 86.7% (82.9–89.3) and 39.8% (31.4–44.8) if OAT and ART are also scaled‐up. Without NGOs, HIV and HCV incidence will increase by 51.6% (23.6–76.3) and 13.4% (4.8–21.9) over 2022–2030. Current NGO provision over 2022–2026 will avert 102,736 (77,611–137,512) DALYs when tracked until 2041 (discounted 3% annually), and cost US$912 (702–1222) per DALY averted; cost‐effective at a willingness‐to‐pay threshold of US$1548/DALY averted (0.5xGDP).ConclusionsNGO activities have a crucial preventative impact among PWID in Ukraine which should be scaled‐up to help achieve HIV and HCV elimination. Disruptions could have a substantial detrimental impact.
Gestational diabetes in women living with HIV in the UK and Ireland: insights from population‐based surveillance data
Authors: Bukasa Laurette L. , Cortina‐Borja Mario , Peters Helen , Taylor Graham P. , Thorne Claire 
Published: April 2023

AbstractIntroductionThe prevalence of gestational diabetes (GD) is increasing globally. While universal risk factors for GD are reasonably well understood, questions remain regarding risks for women living with HIV (WLWH). We aimed to describe GD prevalence, evaluate associated maternal risk factors and assess specific birth outcomes in WLWH in the UK and Ireland.MethodsWe analysed all pregnancies (≥24 weeks’ gestation) in women diagnosed with HIV before delivery, reported to the UK‐based Integrated Screening Outcomes Surveillance Service between 2010 and 2020. Every report of GD was considered as a case. A multivariable logistic regression model, adjusted for women with more than one pregnancy fitted with generalized estimating equations (GEE) assessed the effect of independent risk factors.ResultsThere were 10,553 pregnancies in 7916 women, of which 460 (4.72%) pregnancies had reported GD. Overall, the median maternal age was 33 years (Q1:29–Q3:37), and 73% of pregnancies were in Black African women. WLWH with GD (WLWH‐GD) were older (61% vs. 41% aged ≥35 years, p < 0.001) and more likely to be on treatment at conception (74% vs. 64%, p < 0.001) than women without GD. WLWH‐GD were more likely to have a stillbirth (odds ratio [OR]: 5.38, 95% CI: 2.14–13.5), preterm delivery (OR: 2.54, 95% CI: 1.95–3.32) and fetal macrosomia (OR: 1.14, 95% CI: 1.04–1.24). Independent risk factors for GD included estimated year of delivery (GEE‐adjusted odds ratio [GEE‐aOR]: 1.14, 95% CI: 1.10–1.18), advanced maternal age (≥35 years) (GEE‐aOR: 2.87, 95% CI: 1.54–5.34), Asian (GEE‐aOR: 2.63, 95% CI: 1.40–4.63) and Black African (GEE‐aOR: 1.55, 95% CI: 1.13–2.12) ethnicity. Timing and type of antiretroviral therapy showed no evidence of a relationship with GD in multivariable analyses; however, women with a CD4 count ≤350 cells/μl were 27% less likely to have GD than women with CD4 counts >350 cells/μl (GEE‐aOR: 0.73, 95% CI: 0.50–0.96).ConclusionsGD prevalence increased over time among WLWH but was not significantly different from the general population. Maternal age, ethnicity and CD4 count were risk factors based on available data. Stillbirth and preterm delivery were more common in WLWH‐GD than other WLWH over the study period. Further studies are required to build upon these results.
Restorative justice: A humanistic paradigm for addressing the needs of victims, offenders, and communities
Authors: Scholl Mark B. , Townsend Christopher B. 
Published: April 2023

AbstractRestorative justice (RJ) represents a humanistic approach to addressing the harm caused by juvenile and adult offenders. RJ practices have been shown to reduce recidivism and enhance the holistic wellness of victims and offenders. The authors make recommendations for incorporating RJ into counselor training, identity development, and counseling practices.
Solution‐processed high‐performance organic light‐emitting diodes containing a green‐emitting multiresonant thermally activated delayed fluorescent dendrimer
Authors: Wu Sen , Sun Dianming , Zysmanl‐Colman Eli 
Published: April 2023

AbstractA multi‐resonance thermally activated delayed fluorescence (MR‐TADF) dendrimer emitter and a related reference MR‐TADF compound were designed, synthesized, and characterized for use as narrowband emitters in solution‐processed OLEDs. The 1 wt% doped films in PMMA film revealed that the compounds MR‐D1 and MR‐D2 showed narrowband green emission at λPL of 490 and 495 nm and with FWHM of 23 and 29 nm, respectively. The 50 wt% doped films in mCP still show narrowband green emission at λPL of 495 and 499 nm and with FWHM of 28 nm for MR‐D1 and MR‐D2, respectively, while conserving the small ΔEST of 0.14 and 0.13 eV, respectively. OLEDs containing an emissive layer consisting of 50 wt% MR‐D1 and MR‐D2 in mCP showed high EQEmax of 27.7% and 21.0%, respectively, and low efficiency roll‐off of 19% and 30% at a luminance of 2000 cd/m−2.
Structural Design and Research Progress of Thermally Conductive Polyimide Film – A Review
Authors: Tao Kangkang , Sun Gaohui , Feng Chengcheng , Liu Guangmin , Li Yahui , Chen Rongrong , Wang Jun , Han Shihui 
Published: April 2023

AbstractCurrently, heat accumulation has seriously affected the stabilities and life of electronic devices. Polyimide (PI) film with high thermal conductivity coefficient (λ) has long been held up as an ideal solution for heat dissipation. Based on the thermal conduction mechanisms and classical thermal conduction models, this review presents design ideas of PI films with microscopically ordered liquid crystalline structures which are of great significance for breaking the limit ofλenhancement and describes the construction principles of thermal conduction network in high‐λfiller strengthened PI films. Furthermore, the effects of filler type, thermal conduction paths, and interfacial thermal resistances on thermally conductive behavior of PI film are systematically reviewed. Meanwhile, this paper summarizes the reported research and provides an outlook on the future development of thermally conductive PI films. Finally, it is expected that this review will give some guidance to future studies in thermally conductive PI film.
Estimation on risk of spontaneous abortions by genomic disorders from a meta‐analysis of microarray results on large case series of pregnancy losses
Authors: Peng Gang , Zhou Qinghua , Chai Hongyan , Wen Jiadi , Zhao Hongyu , Taylor Hugh S. , Jiang Yong‐Hui , Li Peining 
Published: April 2023

AbstractA meta‐analysis on seven large case series (>1000 cases) of chromosome microarray analysis (CMA) on products of conceptions (POC) evaluated the diagnostic yields of genomic disorders and syndromic pathogenic copy number variants (pCNVs) from a collection of 35,130 POC cases. CMA detected chromosomal abnormalities and pCNVs in approximately 50% and 2.5% of cases, respectively. The genomic disorders and syndromic pCNVs accounted for 31% of the detected pCNVs, and their incidences in POC ranged from 1/750 to 1/12,000. The newborn incidences of these genomic disorders and syndromic pCNVs were estimated in a range of 1/4000 to 1/50,000 live births from population genetic studies and diagnostic yields of a large case series of 32,587 pediatric patients. The risk of spontaneous abortion (SAB) for DiGeorge syndrome (DGS), Wolf–Hirschhorn syndrome (WHS), and William–Beuren syndrome (WBS) was 42%, 33%, and 21%, respectively. The estimated overall risk of SAB for major genomic disorders and syndromic pCNVs was approximately 38%, which was significantly lower than the 94% overall risk of SAB for chromosomal abnormalities. Further classification on levels of risk of SAB to high (>75%), intermediate (51%–75%), and low (26%–50%) for known chromosomal abnormalities, genomic disorders, and syndromic pCNVs could provide evidence‐based interpretation in prenatal diagnosis and genetic counseling.
Dimensions of sleep quality are related to objectively measured eating behaviors among children at high familial risk for obesity
Authors: Zuraikat Faris M. , Bauman Jonathan M. , Setzenfand Marissa N. , Arukwe David U. , Rolls Barbara J. , Keller Kathleen L. 
Published: April 2023

AbstractObjectiveThe aim of this study was to evaluate whether dimensions of sleep quality were associated with homeostatic and hedonic eating behaviors among children with healthy weight (BMI‐for‐age < 90%) but varying maternal weight status.MethodsA total of 77 children (mean [SD], age: 7.4 [0.6] years; BMI z score: −0.10 [0.7]) with healthy weight and high (n = 32) or low (n = 45) familial obesity risk based on maternal weight status were served an ad libitum meal (homeostatic eating) followed by palatable snacks to assess eating in the absence of hunger (EAH; hedonic eating). Habitual sleep quality was quantified from seven nights of wrist actigraphy. Partial correlations, adjusted for child energy needs, pre‐meal hunger, food liking, and socioeconomic status, evaluated associations of sleep with meal intake and EAH. Additionally, sleep‐by‐obesity risk interactions were assessed.ResultsGreater sleep fragmentation was associated with higher homeostatic meal energy intake, but only among children at high familial obesity risk (p value for interaction = 0.001; β high risk = 48.6, p = 0.001). Sleep fragmentation was not associated with total EAH but was related to higher and lower intake of carbohydrates (r = 0.33, p = 0.003) and fat (r = −0.33, p = 0.003), respectively.ConclusionsAdverse associations of poor sleep with energy intake may be amplified among children already predisposed to obesity. Furthermore, that fragmented sleep relates to preferential intake of carbohydrates over fat during EAH may suggest alterations in taste preferences with poor sleep.
Opportunities for and barriers to anticipatory governance of two lake social–ecological systems in Germany and Canada
Authors: Tanguay Louis , Herzog Laura M. , Audet René , Beisner Beatrix E. , Martin Romina , Pahl‐Wostl Claudia 
Published: April 2023

Abstract

Climate change effects are already being felt around the globe, and governance systems need to adapt to this new reality to foster greater resilience in social–ecological systems (SES). Anticipatory governance is a concept proposed for such a purpose. However, its definition remains rather vague in the literature, as is its practical use for decision makers. In this paper, we contribute to filling these two shortcomings.

First, we conducted a systematic literature review of the concept and derived the following main criteria: foresight, networked engagement, integration and feedback. Second, we use the identified criteria to analyse two social–ecological systems around lakes in Lower Saxony, Germany and in Quebec, Canada.

In both cases, data were generated using a participatory approach (interviews and workshops) with local stakeholders. We examined these data, identifying opportunities and barriers to anticipatory governance. Our findings support, with empirical data for the first time, the claim in the literature that ensemble‐ization—the fact that all anticipatory governance criteria must be put forward jointly and not in isolation—is a facilitator for the emergence of anticipation.

Furthermore, by highlighting opportunities and barriers to anticipatory governance within two temperate lake SES cases, we illustrate how to understand a given system's limitations with respect to anticipatory governance, as well as how to engage with the concept through concrete, already existing opportunities. The proposed course of actions could help design more anticipatory governance systems to support decision‐making processes that could enhance SES resilience.

Read the free Plain Language Summary for this article on the Journal blog.
A self‐healing electrostatic interaction crosslinked temperature sensitive conductive hydrogel for strain and temperature sensor
Authors: Min Jinbiao , Zhou Zhaoxi , Fu Heqing 
Published: April 2023

AbstractA multifunctional hydrogel (C‐ASI‐G) was prepared through a simple acid–base neutralization method. Due to the large number of electrostatic cross‐linked network in the hydrogel and the reversible network, the hydrogel showed good mechanical properties (stress is 495 kPa, strain is 772%) and excellent self‐healing performance (self‐healing efficiency is over 95%). In addition, by adding glycerin to the dispersion medium, hydrogel retain water for a long time and remain flexible at low temperature. The hydrogel contains an ionizable polymer electrolyte, sodium polystyrene sulfonate, so it has outstanding electrical conductivity (0.36 s/m). The hydrogel can be used in general strain sensing and temperature sensing, its conductivity changes with temperature. The temperature and conductivity of the hydrogel were simulated as function, the environmental temperature of the hydrogel could be calculated by the conductivity of the hydrogel, and the error was less than 0.45°C. Because hydrogel can sense stress and temperature stimuli through the change of electrical signals, it will exhibit broad application prospect in the field of bionic intelligent robots.