bluuebunny/crossref_metadata_2025_split huggingface dataset:
Aplikasi Pemuasaan dan Pemberian Pakan Berprobiotik pada Budidaya Ikan Patin di UPR Fish Under Crew, Indralaya Utara, Ogan Ilir
Authors: Dwinanti Sefti heza , Saputra Lingga Rian , Jubaedah Dade 
Published: March 2023

Fish Under Crew, a group of fish farmers located at Pulau Semambu, Indralaya Utara, Ogan Ilir. It rears several fish commodities including catfish. The knowledge of fish farmers about best aquaculture practices are still low and cost production become main problem for them. Therefore, community service held on Aquaculture Department, Sriwijaya University conducted an alternative solution to solved its problem by providing information and pilot culture about fasting and refeeding with probiotic in catfish. The community service was carried out in July-August 2021. The fasting interval was one day then refeeding with commercial pellet enriched by probiotic. Day of culture was 30 days and it compared with batch control which was daily fed without probiotic. Prior and after community service, the fish farmers were interviewed about their knowledge. During fish rearing, the fish farmers also learnt about fish rearing parameters such as growth, survival rate, feed conversion ratio (FCR) and water quality. In the end of culture, fish farmers stated that they were willing to apply the technology.
Harmonisasi Regulasi Pemerintah Pusat dan Pemerintah Daerah diantara Kesejahteraan Sosial dan Kepentingan Nasional
Authors: Fuqoha Fuqoha , Nugraha Lalu Farhan , Soleha Dina Auliana , Khaerunnisa Siti Kamila 
Published: March 2023

Abstract
Problems: Indonesia is stated by the constitution with the system of the Republic of Indonesia. However, the fulfillment of the conception of the State of law gave birth to many regulations regulating the objects of law that are the obligations of the subjects of law as the implementation of the modern legal State. Therefore, it is necessary to adjust between regulations to create a harmonization of legislation.
Purposes : The research aims to analyze the policy of regulatory harmonization between the central government and local governments related to the framework of national interests and social welfare.
Methodology : This research uses a normative juridical approach that perceives law as a norm, rule or principle to analyze data systematically with existing regulations.
Results and Discussions : The government's efforts in harmonizing regulations are efforts to improve the quality of law by taking into account national goals and interests. The problem of regulatory harmonization lies in the relationship between the central government and local governments, where it is necessary to adjust and evaluate laws and regulations according to the hierarchy of laws and regulations in Indonesia. Therefore, any regulation must adjust and be deemed invalid if new legislation is enacted and the regulation remains in effect as long as it does not conflict with the higher regulations.
The Correlation of Islam with Local Culture in the Kawin Cai Tradition in Sundanese Society
Authors: Agustina Dena , Darmalaksana Wahyudin , Busro Busro 
Published: March 2023

<p class="abstrak">This study aims to determine how the relationship between Islam and local culture in the <em>Kawin Cai</em> tradition of the Sundanese people. This research method is a field research by collecting data through observation, interviews, and documentation. The results of this study indicate that there is a mutually supportive correlation between Islam and local culture. The pattern of correlation between Islam and local culture can be seen from the implementation of the <em>Kawin Cai</em> tradition in the Jalaksana District community which contains Islamic values. Activities based on religious values in the <em>Kawin Cai</em> tradition include praying together, eating together and sharing among human beings. These activities have proven the correlation between Islam and local culture in Tatar Sunda, especially in Jalaksana District, Kuningan Regency. This study contributes to realizing harmony in society. It is hoped that the community will understand more and more that the implementation of local traditions is not always associated with shirk, but there is religious value in it. Such comprehension makes a significant contribution to the pluralistic society of Indonesia.</p>
Pengaruh Aplikasi Media Pembelajaran Geogebra Terhadap Kemampuan Berpikir Kritis Dalam Pembelajaran Dan Penyelesaian Persoalan Statistik Pada Prodi Teknik Listrik Bandara
Authors: Suprihartini Yayuk , Taryana Taryana 
Published: March 2023

Based on the results of the author's initial survey observations, the average training score of students of the Airport Electrical Engineering Study Program.in the work on odd semester statistical questions looks still unsatisfactory, this is due to learning that has not used varied media, lack of good learning planning by choosing learning media that suits student learning styles and so on. So efforts need to be made to improve students' critical thinking skills. This requires the ability to manage teaching and learning activities with the use of appropriate and relevant learning media or applications. Based on the above problems, researchers are interested in conducting research on the application of geogebra learning media to critical thinking skills in learning and solving statistical problems in the Airport Electrical Engineering Study Program. The hypothesis in this study is that there is a significant influence of the application of geogebra learning media on critical thinking skills in learning and solving statistical problems in the Airport Electrical Engineering Study Program. This type of research is quasi-experimental research by providing learning treatment assisted by geogebra learning media in statistical learning. The population in this study was all students who attended statistics lectures, which was 25 people. The instrument used in this study is an essay-shaped problem. The hypothesis test used in this study is the t-test, However, previously normality tests and variance homogeneity tests were carried out. Based on the results of the hypothesis test, a sig value is obtained. (2-tailed) = 0.009 < ∝ = 0.05 so it can be concluded that there is a significant influence of the application of geogebra learning media on critical thinking skills in learning and solving statistical problems in the Airport Electrical Engineering Study Program.
Clinical significance of Notch receptors in triple negative breast cancer1
Authors: Shah Heer , Mistry Mittal , Patel Nupur , Vora Hemangini 
Published: March 2023

BACKGROUND: The Notch signaling pathway is an evolutionary conserved cell signaling pathway that plays an indispensable role in essential developmental processes. Aberrant activation of Notch pathway is known to initiate wide array of diseases and cancers. OBJECTIVE: To evaluate the clinical significance of Notch receptors in Triple Negative Breast Cancer. METHODS: We evaluated the association between Notch receptors and clinicopathological parameters including disease-free survival and overall survival of one hundred TNBC patients by immunohistochemistry. RESULTS: Positive expression of nuclear Notch1 receptor (18%) was found be significantly correlated with positive lymph node (p = 0.009), high BR score (p = 0.02) and necrosis (p = 0.004) while cytoplasmic expression of Notch2 receptor (26%) was significantly correlated with metastasis (p = 0.05), worse DFS (p = 0.05) and poor OS (p = 0.02) in TNBC patients. Membrane (18%) and cytonuclear (3%) Notch3 expression were significantly associated with poorly differentiated tumors (p = 0.007), high BR score (p = 0.002) and necrosis (p = 0.03) respectively. However, cytoplasmic Notch3 and Notch4 expression were negatively correlated with poor prognostic factors. CONCLUSIONS: Our data indicated that Notch receptors play a key role in promoting TNBC and mainly, Notch2 may contribute to poor prognosis of the disease. Hence, it is implicated that Notch2 may serve as a potential biomarker and therapeutic target for TNBC.
Innovation And Creativity Based Training Untuk Meningkatkan Kompetensi Pedagogik Guru Dalam Pembelajaran Bahasa Inggris
Authors: Hawanti Santhy , Suwartono Suwartono , Purwidianti Wida , Mujirahayu Tri Septin , Anjarani Shelia 
Published: March 2023

Abstract: Improving the competence of English teachers is necessary to make English learners more qualified. Technological developments and the demands of the global era have created problems in ELT, one of which is the limited competence of teachers to conduct creative and innovative learning. Training is one solution to improve teachers’ pedagogical competence in implementing learning. Innovative and Creative-Based Training is training to develop teacher pedagogical competence in learning English through technology integration in the classroom. The training is attended by English teachers online. The training presents some materials on social media and technology for teaching English. The training participants reported that their knowledge of how to teach creatively and innovatively through integrating technology in the classroom improved after attending this training. This report is obtained from analyzing the questionnaire results after the training activities. Keywords: pedagogic competence, innovative, creative, learningAbstrak: Peningkatan kompetensi guru Bahasa Inggris menjadi suatu kebutuhan dalam upaya menjadikan pembelajaran bahasa Inggris yang lebih berkualitas. Perkembangan teknologi dan tuntutan jaman meninggalkan beberapa masalah, salah satunya adalah keterbatasan kompetensi guru untuk melaksanakan pembelajaran yang kreatif dan inovatif. Pelatihan menjadi salah satu solusi meningkatkan kompetensi pedagogik guru dalam melaksanakan pembelajaran. Innovative and Creative Based Training merupakan pelatihan pengembangan kompetensi pedagogik guru dalam pembelajaran bahasa Inggris melalui integrasi teknologi di kelas. Pelatihan diikuti oleh guru bahasa Inggris SMP dan SMA sederajat di Kabupaten Purbalingga. Kegiatan pelatihan di-lakukan secara daring atau online. Pelatihan menyajikan materi tentang penggunaan media sosial dan teknologi untuk pengajaran Bahasa Inggris. Peserta pelatihan menyampaikan bahwa setelah mengikuti pelatiahn ini pengetahuan mereka terkait bagaimana mengajar yang kreatif dan inovatif melalui integrasi teknologi di kelas. Hal ini diperoleh dari analisis hasil angket yang diberikan setelah kegiatan pelatihan.Kata kunci: kompetensi; kreatif; inovatif; pedagogik; pembelajaran
Approaches and Methods to Teaching Grammar in Textbooks Used in First Semester of English Department Students at ABA Balikpapan
Authors: Rochman Muhammad 
Published: March 2023

This study aims to describe, compare, and contrast approaches and methods to teaching grammar in textbooks used in First Semester of English Department Students at ABA Balikpapan. It chooses, as samples for analysis, textbooks of one particular class to focus on the approaches to teaching grammar in these textbooks. These textbooks are taught for first intermediate class and belong to two different series titled First Semester of English Department Students at ABA Balikpapan opportunities and English for First Semester of English Department Students at ABA Balikpapan. Each of these textbooks follows essentially different approaches to teaching grammar. This study aims to highlight the similarities and differences between the books and reveals the weaknesses and strengths of the approaches in these books. The purpose of the study is changing these textbooks and to reveal the similarities and differences between the old and new textbooks. The data collection method of this research is the collation texts for analysis. The information is breaking down subjectively and quantitatively. The study considerably contributes to the field of language teaching in First Semester of English Department Students at ABA Balikpapan especially grammar teaching through drawing attention of language lecturers, textbook writers, as well as learners to a certain degree, to the weaknesses and strengths of the PPP method (Presentation Practice Production) in the First Semester of English Department Students at ABA Balikpapan opportunities textbook and task-based approach in the English for First Semester of English Department Students at ABA Balikpapan textbook.
The Causes of Code Switching and Code Mixing by Low Level of EFL Learners
Authors: Halwiyah Halwiyah , Oktaviana Fadilla , Hendra Hendra 
Published: March 2023

The objective of this study is to analysis the proses occurred the code switching and code mixing, to find out the types and the cause seventh grades at SMPN 1 KIBIN. This study was categorized into qualitative research design embracing particularly the content analysis. The data in this thesis were collected through observation, transcript conversation and documentation. In analysing the data the writer used triangulation data that consist of data reduction, data display and conclusion drawing/verification. The conclusion for this thesis is that in the conversation in seventh grades at SMPN 1 KIBIN occurred code switching and code mixing with the result of this thesis showed that each have three types of code switching and code mixing used in seventh grade at SMPN 1 KIBIN. (1) The calculation of the percentage code switching, the highest percentage results above are intra sentential switching (52%) because in this type of students are able to say words in English. The ssecond percentage is inter sentential switching (36%) not much different from the previous type, but in this type there are no explanatory sentences after or before. And the last smallest percentage is tag switching (12%) only one student does this type. (2) The calculation of the code mixing percentage, the highest percentage results above are alternation approaches (50.98%), students are able to speak explanatory sentences. The second in this percentage are insertions (word phrases) ( 33.33%) because in this type of students are able to say words in English. And the last, the smallest percentage is congruent lexicalization (dialect) (15.68%) only two students who do this type.
Experience, Thoughts, and Attitudes of Orthopaedic Surgeons about Chronic Postsurgical Pain after Arthroplasty
Authors: BALTA Selin , GÜLTEKİN Muhammet Zeki 
Published: March 2023

Objective: Arthroplasty constitutes a major procedure commonly used in orthopaedic and traumatology surgery, and chronic pain develops in 7%–34% of patients after arthroplasty. This study aims to evaluate the experience, thoughts and attitudes of orthopaedic surgeons about chronic postsurgical pain after arthroplasty.
Methods: The survey was sent to orthopaedic surgeons via the Google survey system. The questionnaire consisted of 17 questions in total; four were related to demographic information, two asked about the surgeons’ experience, three asked for their thoughts, and eight queried their attitudes.
Results: The study evaluated 319 participants. All the orthopaedic surgeons reported that they routinely prescribe for postoperative pain control when discharging patients after arthroplasty. Of those surveyed, 69.7% have used multimodal analgesic therapy to treat chronic postsurgical
pain after arthroplasty. Consultation rates were 5% and 20% for psychiatry and pain physician, respectively. A weak positive correlation was
found between the rate of referring patients with chronic postsurgical pain after arthroplasty to pain physician and the beliefs of orthopaedic surgeons that pain physician can help patients with chronic postsurgical pain after arthroplasty who are unresponsive to pharmacological treatments (p = 0.008, r = 0.148).
Conclusion: Orthopaedic surgeons employ pre-emptive approaches to chronic postsurgical pain after arthroplasty and engage in pharmacological management of chronic postsurgical pain after arthroplasty, but they need to advance further with multidisciplinary treatments and directions.
The Relationship Between Somatization and Depression Types: Comparison of Unipolar Depression and Bipolar Depression
Authors: AKÇA Erdoğdu , DEMİROK AKÇA Zeynep Nur , YILDIZ Mesut 
Published: March 2023

Objective: Somatic symptoms are more likely to be present in depression and anxiety, which causes to waste medical resources due to excessive hospital addmissions. It has been observed that the unclarity of qualitative and quantitative characteristics of somatization depending on the type of depression influences clinical practice less than expected. In the present study, it was aimed to determine the hallmarks of somatic symptoms in depression groups and to investigate the factors that might have an effect on somatic symptoms.
Method: One hundred consecutive patients (50 with Bipolar Depression (BD), 50 with Unipolar Depression (UD)) who met the criteria participated in the study. Patients were assessed for depressive symptoms with Montgomery Asberg Depression Scale and for somatic symptoms with Bradford Somatic Symptom Inventory. Clinical features were obtained by the clinician via Sociodemographic Data Form.
Results: It was found that no significant difference in somatization characteristics between the depression groups. (p> .05). Somatic symptom severity was higher in the UD group in the presence of psychiatric comorbidity (p= .013), but not in BD. Another prominent finding was that the severity of depression was noted the only predictor of severe somatization.
Conclusion: The results show that increased somatic symptoms are associated with the severity of depression, suggesting treatment of depression with somatization rather than differential diagnosis should be primary concern.
Systematic analysis of cell morphodynamics in C. elegans early embryogenesis
Authors: Azuma Yusuke , Okada Hatsumi , Onami Shuichi 
Published: March 2023

The invariant cell lineage ofCaenorhabditis elegansallows unambiguous assignment of the identity for each cell, which offers a unique opportunity to study developmental dynamics such as the timing of cell division, dynamics of gene expression, and cell fate decisions at single-cell resolution. However, little is known about cell morphodynamics, including the extent to which they are variable between individuals, mainly due to the lack of sufficient amount and quality of quantified data. In this study, we systematically quantified the cell morphodynamics in 52 C. elegansembryos from the two-cell stage to mid-gastrulation at the high spatiotemporal resolution, 0.5 μm thickness of optical sections, and 30-second intervals of recordings. Our data allowed systematic analyses of the morphological features. We analyzed sphericity dynamics and found a significant increase at the end of metaphase in every cell, indicating the universality of the mitotic cell rounding. Concomitant with the rounding, the volume also increased in most but not all cells, suggesting less universality of the mitotic swelling. Combining all features showed that cell morphodynamics was unique for each cell type. The cells before the onset of gastrulation could be distinguished from all the other cell types. Quantification of reproducibility in cell-cell contact revealed that variability in division timings and cell arrangements produced variability in contacts between the embryos. However, the area of such contacts occupied less than 5% of the total area, suggesting the high reproducibility of spatial occupancies and adjacency relationships of the cells. By comparing the morphodynamics of identical cells between the embryos, we observed diversity in the variability between cells and found it was determined by multiple factors, including cell lineage, cell generation, and cell-cell contact. We compared the variabilities of cell morphodynamics and cell-cell contacts with those in ascidianPhallusia mammillataembryos. The variabilities were larger inC. elegans, despite smaller differences in embryo size and number of cells at each developmental stage.
A computational framework for testing hypotheses of the minimal mechanical requirements for cell aggregation using early annual killifish embryogenesis as a model
Authors: Montenegro-Rojas Ignacio , Yañez Guillermo , Skog Emily , Guerrero-Calvo Oscar , Andaur-Lobos Martin , Dolfi Luca , Cellerino Alessandro , Cerda Mauricio , Concha Miguel L. , Bertocchi Cristina , Rojas Nicolás O. , Ravasio Andrea , Rudge Timothy J. 
Published: March 2023

Introduction: Deciphering the biological and physical requirements for the outset of multicellularity is limited to few experimental models. The early embryonic development of annual killifish represents an almost unique opportunity to investigate de novo cellular aggregation in a vertebrate model. As an adaptation to seasonal drought, annual killifish employs a unique developmental pattern in which embryogenesis occurs only after undifferentiated embryonic cells have completed epiboly and dispersed in low density on the egg surface. Therefore, the first stage of embryogenesis requires the congregation of embryonic cells at one pole of the egg to form a single aggregate that later gives rise to the embryo proper. This unique process presents an opportunity to dissect the self-organizing principles involved in early organization of embryonic stem cells. Indeed, the physical and biological processes required to form the aggregate of embryonic cells are currently unknown.Methods: Here, we developed an in silico, agent-based biophysical model that allows testing how cell-specific and environmental properties could determine the aggregation dynamics of early Killifish embryogenesis. In a forward engineering approach, we then proceeded to test two hypotheses for cell aggregation (cell-autonomous and a simple taxis model) as a proof of concept of modeling feasibility. In a first approach (cell autonomous system), we considered how intrinsic biophysical properties of the cells such as motility, polarity, density, and the interplay between cell adhesion and contact inhibition of locomotion drive cell aggregation into self-organized clusters. Second, we included guidance of cell migration through a simple taxis mechanism to resemble the activity of an organizing center found in several developmental models.Results: Our numerical simulations showed that random migration combined with low cell-cell adhesion is sufficient to maintain cells in dispersion and that aggregation can indeed arise spontaneously under a limited set of conditions, but, without environmental guidance, the dynamics and resulting structures do not recapitulate in vivo observations.Discussion: Thus, an environmental guidance cue seems to be required for correct execution of early aggregation in early killifish development. However, the nature of this cue (e.g., chemical or mechanical) can only be determined experimentally. Our model provides a predictive tool that could be used to better characterize the process and, importantly, to design informed experimental strategies.