bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characterization of transitional memory CD4+ and CD8+ T-cell mobilization during and after an acute bout of exercise
Authors: Hunt Rebekah M. , Elzayat Mahmoud T. , Markofski Melissa M. , Laughlin Mitzi , LaVoy Emily C. 
Published: April 2023

T-cell subsets, including naïve (NA), central memory (CM), transitional memory (TM), effector memory (EM), and RA + effector memory (EMRA), differ in phenotype and function. T-cells are mobilized by exercise, with differences in the magnitude of mobilization between subsets. However, the response of TM T-cells to exercise has not yet been described. Further, T-cells expressing the late differentiation marker CD57 are known to be highly responsive to exercise, but the relative response of CD57 + and CD57- within T-cell subsets is unknown. We therefore aimed to characterize the exercise-induced mobilization of TM T-cells, as well as to compare the exercise response of CD57 + and CD57- cells within T-cell subsets.MethodsSeventeen participants (7 female; aged 18–40 years) cycled 30 min at 80% of their estimated maximum heart rate. Venous blood obtained pre, post, and 1H post-exercise was analyzed by flow cytometry. CD45RA, CCR7, and CD28 expression within CD4 + and CD8+ T-cells identified NA, CM, TM, EM, and EMRA subsets. CD57 expression within EM, EMRA, and CD28+ T-cells was also quantified. The relative mobilization of each subset was compared by calculating fold change in cell concentration during (ingress, post/pre) and after exercise (egress,1H post/post). Cytomegalovirus (CMV) serostatus was determined by ELISA and was considered in models.ResultsTM CD8+ T-cell concentration was greater post-exercise than pre-exercise (138.59 ± 56.42 cells/µl vs. 98.51 ± 39.68 cells/µl, p &lt; 0.05), and the proportion of CD8 + with a TM phenotype was elevated 1H post-exercise (1H: 32.44 ± 10.38% vs. Pre: 30.15 ± 8.77%, p &lt; 0.05). The relative mobilization during and after exercise of TM T-cells did not differ from NA and CM but was less than EM and EMRA subsets. Similar results were observed within CD4+ T-cells. CD57 + subsets of CD28+ T-cells and of EM and EMRA CD8+ T-cells exhibited a greater relative mobilization than CD57- subsets (all p &lt; 0.05).ConclusionThese results indicate TM CD4 + and CD8+ T-cells are transiently mobilized into the blood with exercise, but not to as great of an extent as later differentiated EM and EMRA T-cells. Results also indicate CD57 identifies highly exercise responsive cells within CD8+ T-cell subsets.
Effects of daily static stretch training over 6 weeks on maximal strength, muscle thickness, contraction properties, and flexibility
Authors: Wohlann Tim , Warneke Konstantin , Hillebrecht Martin , Petersmann Astrid , Ferrauti Alexander , Schiemann Stephan 
Published: April 2023

PurposeStatic stretch training (SST) with long stretching durations seems to be sufficient to increase flexibility, maximum strength (MSt) and muscle thickness (MTh). However, changes in contraction properties and effects on muscle damage remain unclear. Consequently, the objective of the study was to investigate the effects of a 6-week self-performed SST on MSt, MTh, contractile properties, flexibility, and acute response of creatine kinase (CK) 3 days after SST.MethodsForty-four participants were divided into a control (CG, n = 22) and an intervention group (IG, n = 22), who performed a daily SST for 5 min for the lower limb muscle group. While isometric MSt was measured in leg press, MTh was examined via sonography and flexibility by functional tests. Muscle stiffness and contraction time were measured by tensiomyography on the rectus femoris. Additionally, capillary blood samples were taken in the pretest and in the first 3 days after starting SST to measure CK.ResultsA significant increase was found for MSt (p &lt; 0.001, η2 = 0.195) and flexibility in all functional tests (p &lt; 0.001, η2 &gt; 0.310). Scheffé post hoc test did not show significant differences between the rectus femoris muscle inter- and intragroup comparisons for MTh nor for muscle stiffness and contraction time (p &gt; 0.05, η2 &lt; 0.100). Moreover, CK was not significantly different between IG and CG with p &gt; 0.05, η2 = 0.032.DiscussionIn conclusion, the increase in MSt cannot be exclusively explained by muscular hypertrophy or the increased CK-related repair mechanism after acute stretching. Rather, neuronal adaptations have to be considered. Furthermore, daily 5-min SST over 6 weeks does not seem sufficient to change muscle stiffness or contraction time. Increases in flexibility tests could be attributed to a stretch-induced change in the muscle–tendon complex.
Reducing oil absorption of falafel balls by using edible coating films containing dried orange-albedo powder or dried apple peel during deep frying
Authors: Angor Malak 
Published: April 2023

IntroductionThe purpose of this study is to examine the effects of varying proportions of dried-orange-albedo and dried-apple-peel powders in edible coating films for falafel balls on their subsequent oil uptake and sensory properties when used during deep frying in oil.MethodsCoating solutions of 3%, 5%, and 7% w/v of either orange albedo or apple-peel powder were prepared and heated to 90°C for 5 min, after which they were cooled. In the next step, the falafel-ball samples were air-dried after dipping them in the coating solutions. The falafel balls coated with different solutions were then deep-fried and their oil and moisture content with the calculation of oil uptake and moisture retention was analyzed, along with the evaluation of sensory attributes.ResultsAccording to the results, oil uptake during deep oil frying was reduced to varying extents in all coating treatments. For both orange albedo and apple-peel powder, the coating films containing 5% of either were found to be the most effective level in reducing the oil uptakes.DiscussionsThe coating films prepared from orange albedo reduced oil uptake more than those containing the same amount of apple peel for all levels. All falafel ball samples prepared with the different coatings were found to have improved sensory features compared with the uncoated control.
Intradural extramedullary spinal cord meningioma with a rare extradural foraminal extension: A case report
Authors: Almatrafi Faisal , Alomair Majed , Alojan Abdulrazaq , Alkhaldi Mohammed , Alsafwani Noor , Aseeri Abdullah , Alshahrani Abdulelah , Alsalmi Sultan , Alqahtani Mohammad 
Published: April 2023

BackgroundMeningiomas are mostly benign and slow-growing neoplasms of the central nervous system. Spinal meningiomas account for up to 45% of all intradural spinal tumors in adults and up to 25%–45% of all spinal tumors. Spinal extradural meningiomas are rare and may be easily confused with malignant neoplasms.Case descriptionA 24-year-old woman was presented to our hospital with paraplegia and loss of sensation in the T7 dermatome and lower body. MRI findings showed T6-T7 right-sided intradural extramedullary and extradural lesion, measuring 1.4 cm × 1.5 cm × 3 cm, extending to the right foramen, compressing the spinal cord, and displacing it to the left. Hyperintense lesion on T2 and hypointense lesion on T1 were observed. The patient reported improvement after surgery and during follow-up. We recommend maximizing the decompression during surgery to achieve better clinical outcome. Extradural meningiomas represent 5% of all meningiomas; therefore, having an intradural on top of extradural meningioma with extraforaminal extensions makes this a unique and rare case.ConclusionMeningiomas can be easily missed in diagnosis depending on imaging and the pathognomonic pattern it represents, which can mimic other pathologies, such as schwannomas. Therefore, surgeons should always suspect their patient having a meningioma even if the pattern is not typical. Moreover, preoperative preparation, such as navigation and defect closure, must be taken in case it turns out be a meningioma instead of the presumed pathology.
A Method Based on Temporal Embedding for the Pairwise Alignment of Dynamic Networks
Authors: Cinaglia Pietro , Cannataro Mario 
Published: April 2023

In network analysis, real-world systems may be represented via graph models, where nodes and edges represent the set of biological objects (e.g., genes, proteins, molecules) and their interactions, respectively. This representative knowledge-graph model may also consider the dynamics involved in the evolution of the network (i.e., dynamic networks), in addition to a classic static representation (i.e., static networks). Bioinformatics solutions for network analysis allow knowledge extraction from the features related to a single network of interest or by comparing networks of different species. For instance, we may align a network related to a well known species to a more complex one in order to find a match able to support new hypotheses or studies. Therefore, the network alignment is crucial for transferring the knowledge between species, usually from simplest (e.g., rat) to more complex (e.g., human). Methods: In this paper, we present Dynamic Network Alignment based on Temporal Embedding (DANTE), a novel method for pairwise alignment of dynamic networks that applies the temporal embedding to investigate the topological similarities between the two input dynamic networks. The main idea of DANTE is to consider the evolution of interactions and the changes in network topology. Briefly, the proposed solution builds a similarity matrix by integrating the tensors computed via the embedding process and, subsequently, it aligns the pairs of nodes by performing its own iterative maximization function. Results: The performed experiments have reported promising results in terms of precision and accuracy, as well as good robustness as the number of nodes and time points increases. The proposed solution showed an optimal trade-off between sensitivity and specificity on the alignments produced on several noisy versions of the dynamic yeast network, by improving by ∼18.8% (with a maximum of 20.6%) the Area Under the Receiver Operating Characteristic (ROC) Curve (i.e., AUC or AUROC), compared to two well known methods: DYNAMAGNA++ and DYNAWAVE. From the point of view of quality, DANTE outperformed these by ∼91% as nodes increase and by ∼75% as the number of time points increases. Furthermore, a ∼23.73% improvement in terms of node correctness was reported with our solution on real dynamic networks.
Descriptions of Three New Species of the Genus Acerataspis Uchida, 1934 (Hymenoptera, Ichneumonidae, Metopiinae), with an Illustrated Identification Key to Extant Species
Authors: Liu Jing-Xian , Reshchikov Alexey , Chen Hua-Yan 
Published: April 2023

The Asian genus Acerataspis Uchida, 1934 is reviewed based on both morphology and DNA barcodes. Ten species are recognized in total, of which three species from Yunnan Province of China are described as new: Acerataspis maliae sp. nov., A. seperata sp. nov. and A. similis sp. nov. The male of A. fukienensis Chao, 1957 is described and illustrated for the first time. The genus is recorded from Thailand and Southeast Asia for the first time. An illustrated key to all known extant species is provided. With the supplement of DNA barcodes, a few diagnostic morphological characters are found useful in species identification.
Adaption of Pseudomonas ogarae F113 to the Rhizosphere Environment—The AmrZ-FleQ Hub
Authors: Blanco-Romero Esther , Durán David , Garrido-Sanz Daniel , Redondo-Nieto Miguel , Martín Marta , Rivilla Rafael 
Published: April 2023

Motility and biofilm formation are two crucial traits in the process of rhizosphere colonization by pseudomonads. The regulation of both traits requires a complex signaling network that is coordinated by the AmrZ-FleQ hub. In this review, we describe the role of this hub in the adaption to the rhizosphere. The study of the direct regulon of AmrZ and the phenotypic analyses of an amrZ mutant in Pseudomonas ogarae F113 has shown that this protein plays a crucial role in the regulation of several cellular functions, including motility, biofilm formation, iron homeostasis, and bis-(3′-5′)-cyclic dimeric guanosine monophosphate (c-di-GMP) turnover, controlling the synthesis of extracellular matrix components. On the other hand, FleQ is the master regulator of flagellar synthesis in P. ogarae F113 and other pseudomonads, but its implication in the regulation of multiple traits related with environmental adaption has been shown. Genomic scale studies (ChIP-Seq and RNA-Seq) have shown that in P. ogarae F113, AmrZ and FleQ are general transcription factors that regulate multiple traits. It has also been shown that there is a common regulon shared by the two transcription factors. Moreover, these studies have shown that AmrZ and FleQ form a regulatory hub that inversely regulate traits such as motility, extracellular matrix component production, and iron homeostasis. The messenger molecule c-di-GMP plays an essential role in this hub since its production is regulated by AmrZ and it is sensed by FleQ and required for its regulatory role. This regulatory hub is functional both in culture and in the rhizosphere, indicating that the AmrZ-FleQ hub is a main player of P. ogarae F113 adaption to the rhizosphere environment.
Princípios bioéticos e legais da ortotanásia: uma revisão integrativa
Authors: Costa Ana Juciane , Mauriz Patrícia Cristine Bezerra Tavares , Lopes Elisson Fernando Silva , Rodovalho Hannah Olga Pereira , Timbó Filho José Marques , Barbosa Julianne dos Santos 
Published: April 2023

Este estudo objetiva verificar as bases éticas, científicas e legais referentes à ortotanásia, especialmente na visão bioética. Para realização desta pesquisa, adotou-se uma revisão integrativa de artigos publicados nos últimos 5 (cinco) anos utilizando os descritores DECs e os seguintes operadores booleanos: bioética AND fim da vida; bioética AND Ortotanásia; fim da vida AND Ortotanásia. Nesta pesquisa, foram incluídos no total 7 (sete) artigos, que correspondiam aos objetivos estabelecidos. Verificou-se que, à luz do ordenamento pátrio brasileiro, a ortotanásia, é convenientemente condita em vários artigos do Código Penal. Destarte, ortotanásia visa estabelecer que o fim da vida do paciente ocorra de maneira digna, com cuidados e objetivando o menor sofrimento possível, em que a equipe multiprofissional buscará aliviar e confortar o paciente seus familiares. No Brasil, existem algumas legislações que abordam a prática da ortotanásia, tais como: Decreto-Lei nº 2.848, de 7 de dezembro de 1940; Lei nº 8.080, de 19 de setembro de 1990; Lei nº 10.406, de 10 de janeiro de 2002; Resolução CFM nº.1.805/2006; Resolução CFM nº 1.931, de 17 de setembro de 2009 e Projeto de Lei 6.715/2009. No entanto, percebeu-se, a partir da literatura científica acerca do tema, que os profissionais de saúde não sentem amparados para atuar nessas situações. Ademais, existem outros fatores que impactam na prática da ortotanásia, como as questões de ordem pessoal a exemplo, a religião, impactando na postura dos profissionais de saúde perante temas que abrangem conflitos éticos.
Hematpoese: a importância para a homeostase
Authors: Labarba Arthur Azeredo , Silvestre Isabella Soares , Martins Giovanna Cabrini Franco , Sampaio Kenneth Candeira 
Published: April 2023

INTRODUÇÃO: A hematopoese conceitua-se como o processo de regulação e produção contínua de células do sangue. Esse ciclo garante que o número de células especializadas seja reposto, além de auxiliar na homeostase em meio a situações que exijam do organismo uma produção acentuada, como processos infecciosos. OBJETIVO: realizar uma revisão bibliográfica a respeito da importância do processo hematopoetico. MÉTODO: Realizou-se uma revisão sistemática através da base de dados Scielo, CSH Perspectives, além de livros como Guyton, Moore, Lorenzi, Zago, e Junqueira usando-se as palavras-chave: hematopoese, hematopoese e homeostase, Células hematopoéticas, medula óssea. Foram selecionados materiais publicados entre 2001 e 2021. A hematopoese trata-se de uma atividade fundamental para a homeostase do organismo, onde conceitos básicos desse sistema foram definidos biologicamente. Mas ao mesmo tempo, muitas disputas na pesquisa da hematopoiese ilustram nossa compreensão ainda limitada revelando a relevância de se estudar a temática. CONCLUSÃO: Diante do exposto, tem-se que a hematopoese, é vital desde a vida intrauterina, ocorrendo em diferentes sítios conforme as fases do desenvolvimento. Para que esse sistema tenha funcionamento pleno necessita-se da ação de fatores que induzam a proliferação, diferenciação e crescimento das células ainda imaturas. Portanto, é indubitável que sem esse processo seria inviável manter o equilíbrio do organismo, principalmente em quadros como infecções, sangramentos, hipóxia e anemias, que exigem uma adaptação da hematopoese. Não obstante, também está sendo pautado o desenvolvimento de terapias que tem a capacidade de revolucionar tratamentos, a exemplo da utilização de CTH’s na anemia falciforme. Por conseguinte, apesar da evidente importância da hematopoese, ainda são escassos os estudos atualizados e aprofundados a respeito do tema, demandando uma maior atenção da comunidade científica.
Особенности физической реабилитации недоношенных детей с поражением опорно-двигательного аппарата, вызванного наследственными заболеваниями скелета
Authors: Vasilenko E.V. 
Published: April 2023

Представлены данные анализа научно-методической литературы в области методов физической реабилитации недоношенных детей с поражением опорно-двигательного аппарата, вызванного наследственными заболеваниями скелета.
Рассмотрены различные методы физической реабилитации, использующиеся в настоящее время в восстановительном лечении данной категории новорожденных.
Сформулированы основные принципы алгоритма построения программ физической реабилитации.
Результаты исследования выявили важность индивидуального подхода в выборе методов реабилитации, перспективность разработки и внедрения новых методик профилактики и реабилитации недоношенных новорожденных.
Применение средств физической культуры для становления молодого специалиста технического вуза
Authors: Bondar Ekaterina Abdullaevna , Kosukhin Viktor Viktorovich 
Published: April 2023

В статье рассмотрена роль физической культуры в подготовке будущих специалистов, вопросы укрепления и сохранения здоровья студентов с помощью средств физической культуры.
AGRICULTURE OF THE VOLOGDA REGION
Authors: Маклахов А.В. , Симонов Г.А. , Марценюк Е.А. 
Published: April 2023

В статье приведены показатели производства продукции растениеводства и животноводства АПК Вологодской области, а также инвестиции в сельское хозяйство. Показана роль эффективных методов хозяйствования, использование инновационных технологий для повышения качества получаемой продукции в АПК региона.
The article provides indicators of production of crop production and animal husbandry in the agro-industrial complex of the Vologda region, as well as investments in agriculture. The role of effective management methods, the use of innovative technologies to improve the quality of the products obtained in the agro-industrial complex of the region is shown.
Effect of initial-learning dataset on etching profile optimization using machine learning in plasma etching
Authors: Dobashi T. , Kobayashi H. , Okuyama Y. , Ohmori T. 
Published: April 2023

Abstract
Machine learning (ML) was applied to optimize the etching profile for a line and space pattern sample in plasma etching. To investigate the effect of different initial-learning datasets on the optimization of the etching profile, high-, medium-, and low-quality datasets were prepared. The high-quality dataset was composed of etching results relatively close to a target etching profile. The low-quality dataset was composed of etching results relatively far from the target etching profile. The medium-quality dataset was intermediate between the high- and low-quality datasets. For the ML, the kernel ridge regression method was used. After six learning cycles, better etching results were obtained from the medium- and low-quality datasets than from the whole initial-learning dataset. However, the etching results from the high-quality dataset did not exceed those from the whole initial-learning dataset. These results indicate that an initial-learning dataset that has etching results far from the target profile can be useful for optimizing etching profiles.
Thermodynamic and Theoretical Studies of some N-substituted phthalimides Derivatives
Authors: Mohammed Shamil Ali  
Published: April 2023

N,N’-(biphenyl)bisphthalimide and N-(4’-amino __ biphenyl)phthalimide were chosen in this study to compare the stabilitytheoretically by density function theory (DFT) using B3LYP/6-31Gmethod, the electronic properties of these imides indicate that compound(N,N’-(biphenyl)bisphthalimide) is more stable than the compound (N-(4’-aminobiphenyl) phthalimide) by (-0.8422 eV or -19.4215 Keal.mo!'')depending on the values of HOMO, synthesis _ reaction of imide isspontaneous and endothermic at temperature 150°C according to the valuesof A,S, A,G and A,H thermodynamically.INTRODUCTION Imides are organic compounds for N-monoacy] derivatives of amidewhich may be open or cyclic chain. Cyclic imide constitute an importantclass of compounds possessing bis-amide linkage with common nitrogen.Imide very important molecules because their activity as antibacterial,antifungal, anti nociceptive, anticonvulsant and antitumor!, They havebeen useful building blocks in the synthesis of natural products’! and otherheterocycles as well!*!, Their ability to cross biological membranes in-vivo,due to their hydrophobicity is well established'“!,The preparation of imideshas received considerable attention during recent year A number ofmethods such as acylation of amides with acyl chlorides, anhydrides andcarboxylic esters or acids), amino carbonylation of aryl bromides'*! havebeen reported for the preparation of acyclic imides.COMPUTATIONAL METHODS Molecular geometries of the all molecules were fully optimized withthe hybrid density functional theory (DFT) B3LYP method!”"'"! using the6-31G basis set!!?!3! by means of the Gaussian 09, revision A.02!"4! usedfor all geometry optimizitions, thermodynamic functions at conditions
Influence of pH, light and temperature on the stability of Amoxicillin and Triprolidine HCI.
Authors: Thoraia M.AlKalisy  , Maad talib abdulrahman  
Published: April 2023

The stability of two drugs Amoxicillin and Triprolidine . HCl was
studied in aqueous solution . The results show that Amoxicillin was stable in
PH range (2-8), while it decomposed at pH more than (6) . The same results
have been shown when the solution temperature was varied between 25-
100C° , the decomposition occurred at a temperature above 60C° . When
Amoxicillin exposed to UV light in presence of O, gas , it was unstable , but
was relatively stable in the absence of O> gas . Triprolidine HCl was stable
under the same above condition and factors .
UV- Visible spectrometer was used to follow the spectrum of two drugs.
العلاقات التركية الاذرية في مجال اللغة والتعليم 1991-2003
Authors: أ.م.د. عماد نعمة العبادي  , زينب صالح السعدي  
Published: April 2023

مستخلص البحث:
تعد دراسة العلاقات الدولية من الدراسات التي شهدت في الاونة الاخيرة اهتماماً ملحوظاً ولأهميتها تم دراسة العلاقات الثقافية التركية الاذرية وبالتحديد اللغة والتعليم اذا تكمن اهمية الموضوع في هذين المجالين اللذان يشكلان الحجر الاساس للثقافة ، لذلك جهد كلاهما على التعاون والتطوير اللغة و التعليم بينهما ، خاصة ان هذا الموضوع لم يتم التطرق اليه في الدراسات العربية ، وتتميز هذه الدراسة بقربها الزمني (1991-20003) ، كما تتمتع كل من جمهوريتين التركية والاذرية بأهمية كبيرة وتأثير في الساحة الدولية ، يغطي البحث اصول اللغة المشتركة بين تركيا واذربيجان وكيف نشأة اللغة التركية الاذرية التي هي احد فروع اللغة التركية ، كما وضح بداية العلاقة في مجال التعليم مع ذكر اهم الاتفاقيات والبروتوكولات المنعقدة بينهما ، والزيارات الرسمية لكلا البلدين.
يغطي بحثنا ما يلي :

اللغة التركية الاذرية المشتركة بين البلدين.
الاتفاقيات والبروتوكولات العلمية بين تركيا واذربيجان.

الكلمات المفتاحية : العلاقات ، اللغة التركية ، اذربيجان.