bluuebunny/crossref_metadata_2025_split huggingface dataset:
South African extreme weather during the 1877–1878 El Niño
Authors: Brugnara Yuri , Brönnimann Stefan , Grab Stefan , Steinkopf Jessica , Burgdorf Angela‐Maria , Wilkinson Clive , Allan Rob 
Published: September 2023

AbstractThe El Niño event of 1877–1878 was one of the strongest during the last 150 years and had worldwide impacts, bringing widespread severe droughts, but also unusually wet conditions to some regions. We focus on the effects that this event had on precipitation in South Africa, taking advantage of newly rescued instrumental data, as well as documentary sources. Through the assimilation of the new data into an existing reanalysis, we could improve the synoptic reconstruction of specific weather events. However, much remains to be done in order to achieve a good and consistent reconstruction quality for the region.
Peristaltic transport of a Ree‐Eyring fluid with non‐uniform complaint channel: An analysis through varying conditions
Authors: Li Shuguang , Rajashekhar C. , Nisar K. S. , Mebarek‐Oudina Fateh , Vaidya H. , Khan M. Ijaz , Prasad K. V. , Balachandra H. , Manjunatha G. 
Published: September 2023

AbstractThe peristaltic mechanism of a non‐Newtonian Ree‐Eyring liquid in the presence of variable liquid properties and heat transfer is an integral component of technology and healthcare systems. This study aims to investigate and analyze this mechanism, taking into account the influence of wall properties and variable liquid properties. The long wavelength and Low Reynolds approximations are used in the model designed for this purpose. A regular perturbation technique solves the resulting nonlinear partial differential equations with the proper non‐dimensional parameters. The magnetic field's influence is crucial in determining the fluid flow behavior, whereas the variable liquid properties significantly affect the temperature profiles. This research contributes to an improved understanding of peristalsis in the context of Ree‐Eyring liquids and has potential implications for several technical and medical applications.
Analysis of entropy generation and Joule heating effects for MHD peristaltic flow over an asymmetric channel with mixed convective conditions
Authors: Tanveer Arooj , Ashraf Muhammad Bilal , Zaib‐Un‐Nisa  
Published: September 2023

AbstractThe investigation of entropy generation in peristaltic flow in an asymmetric channel under mixed convective conditions is a contribution to the body of literature. The used transport model includes appropriate boundary conditions along with continuity, momentum, energy, and concentration equations. Under the presumptions of a long wavelength and a low Reynolds number, the analysis is carried out. The analysis takes into account important elements including Joule heating, magnetohydrodynamics (MHD), and heat and mass transmission. An approach using BVP4C is used to analyze the governing system. The research adds to the body of knowledge in the subject by revealing important details about the complex interactions between these variables and how they affect peristaltic flow's creation of entropy. The originality of this work resides in its thorough examination of numerous crucial elements, including MHD, Joule heating, and mass and heat transport. The originality of this research is further enhanced by the analysis of the impacts of various parameters on velocity, temperature, concentration, pressure gradient, and streamlines. This study provides a novel viewpoint and a deeper knowledge of the entropy generation phenomenon in peristaltic flow, opening the door for potential applications in numerous disciplines including fluid dynamics, biomedical engineering, and transport processes.
Upregulation of HDAC9 in hippocampal neurons mediates depression-like behaviours by inhibiting ANXA2 degradation
Authors: Dai Yunjian , Wei Taofeng , Huang Yuwen , Bei Yun , Lin Haoran , Shen Zexu , Yu Lingyan , Yang Mingdong , Xu Huimin , He Wei , Lin Zheng , Dai Haibin 
Published: September 2023

AbstractMajor depressive disorder (MDD) is a pervasive and devastating mental disease. Broad spectrum histone deacetylase (HDAC) inhibitors are considered to have potential for the treatment of depressive phenotype in mice. However, due to its non-specific inhibition, it has extensive side effects and can not be used in clinical treatment of MDD. Therefore, finding specific HDAC subtypes that play a major role in the etiology of MDD is the key to develop corresponding specific inhibitors as antidepressants in the future. Copy number variation in HDAC9 gene is thought to be associated with the etiology of some psychiatric disorders. Herein, we found that HDAC9 was highly expressed in the hippocampus of chronic restraint stress (CRS) mouse model of depression. Upregulation of HDAC9 expression in hippocampal neurons of mice induced depression-like phenotypes, including anhedonia, helplessness, decreased dendritic spine density, and neuronal hypoexcitability. Moreover, knockdown or knockout of HDAC9 in hippocampal neurons alleviated depression-like phenotypes caused by chronic restraint stress (CRS) in WT mice. Importantly, using immunoprecipitation–mass spectrometry (IP–MS), we further found that Annexin A2 (ANXA2) was coupled to and deacetylated by HDAC9. This coupling resulted in the inhibition of ubiquitinated ANXA2 degradation and then mediates depression-like behavior. Overall, we discovered a previously unrecognized role for HDAC9 in hippocampal neurons in the pathogenesis of depression, indicating that inhibition of HDAC9 might be a promising clinical strategy for the treatment of depressive disorders.
Element Concentrations in Muscle and Liver Tissue of Two Eel Species from the Incomati River, Mozambique
Authors: Erasmus Johannes H. , Herselman Shaun , Wepener Victor 
Published: September 2023

AbstractMany rural communities in Mozambique get their income from fisheries, as well as consume fish as an inexpensive source of protein. In Mozambique, fish consumption from small-scale fisheries dependent families can range between 60 and 150 kg/person/year. Anguillid eels have important social value to vulnerable local communities in the Incomati Basin. Anguillid eels in the lower Incomati Basin are targeted for consumption, as well as cultural rituals by traditional healers. The aim of the present study was to determine trace element concentrations in environmental matrices, bioaccumulation patterns in muscle and liver tissue of two Anguilla species (Anguilla mossambica and Anguilla marmorata), as well as the chronic health risk these elements pose to regular consumers in the lower Incomati River. Bioaccumulation of elements from the water had a higher effect on both muscle and liver tissues, where only the bioaccumulation of Pb in the sediments played a major role. From the human health risk assessment, Hg pose non-carcinogenic risk, whereas As, Cr, and Ni pose carcinogenic risks.
Modeling of blood flow in the framework of micropolar theory
Authors: Vilchevskaya Anastasiya E. , Vilchevskaya Elena N. , Müller Wolfgang H. , Eremeyev Victor A. 
Published: September 2023

AbstractIn this paper, we study the blood flow through blood vessels of various radii (including the case of variable cross section as well as modeling the blood flow through venae and arteries). Two approaches are discussed in order to mimic the dependence of blood viscosity on red blood cells aggregation, which changes with the shear rate and position inside the vessel: Two microstructural parameters together with empirical constitutive equations as a characteristic of aggregation are proposed, namely the microinertia as well as the volume fraction of blood particles (erythrocytes, platelets and leukocytes). Consequently, the Navier–Stokes system of equations for an incompressible fluid is supplemented by a constitutive equation for the moment of inertia in one case and for the volume fraction in another. The problems are solved numerically by the finite volume method for vessels of various geometries in spatial description. A comparison with experimental data for a narrow capillary shows the efficiency of the proposed constitutive equations for describing blood flow. Also, velocity profiles are obtained on the basis of compiled empirical formula for various sections of a blood vessel of variable radius. In addition, the flow through vessels of the human circulatory system, such as the inferior vena cava and the carotid artery, are studied.
Is day-case surgery feasible for laser endoscopic enucleation of the prostate? A systematic review
Authors: Yilmaz Mehmet , Karaaslan Mustafa , Polat Muhammed Emin , Tonyali Senol , Aybal Halil Çağrı , Şirin Mehmet Emin , Toprak Tuncay , Tunç Lütfi , Gratzke Christian , Miernik Arkadiusz 
Published: September 2023

Abstract
Purpose
Laser endoscopic enucleation of the prostate (EEP) for benign prostatic obstruction has become increasingly prevalent worldwide. Considering the medical cost-savings and concomitantly fewer nosocomial infections, the feasibility of same-day postoperative discharge of patients who have undergone laser EEP in terms of its safety and effectiveness has become a subject matter of growing interest. We aimed to review those studies focussing on day-case surgery (DCS) in patients undergoing laser EEP.

Methods
A systematic search was conducted using PubMed-MEDLINE and Web of Science databases until October 2022 with the following search terms: “same day discharge AND laser enucleation of the prostate”, “day-case AND laser enucleation of the prostate”, “same day surgery AND laser enucleation of the prostate” and “one day surgery AND laser enucleation of the prostate” by combining PICO (population, intervention, comparison, outcome) terms. We identified 15 eligible studies.

Results
While 14 of the studies focussed on holmium laser EEP, one focused on thulium laser vapoenucleation of the prostate. We observed an improvement in functional parameters in all studies we reviewed, and DCS success and readmission rates ranged between 35.3–100% and 0–17.8%, respectively. The complication rates varied between 0 and 36.7%, most of the complicatons were Clavien-Dindo (CD) I and II. CD ≥ III complications did not significantly differ between same day discharge (SDD) and non-SDD groups in the studies.

Conclusion
Laser EEP is feasible and promising DCS treatment option delivering improved functional parameters compared to baseline values, and lower perioperative complication and readmission rates in certain patients.
The genome of Anoplarchus purpurescens (Stichaeidae) reflects its carnivorous diet
Authors: Le Ninh , Heras Joseph , Herrera Michelle J. , German Donovan P. , Crummett Lisa T. 
Published: September 2023

AbstractDigestion is driven by digestive enzymes and digestive enzyme gene copy number can provide insights on the genomic underpinnings of dietary specialization. The “Adaptive Modulation Hypothesis” (AMH) proposes that digestive enzyme activity, which increases with increased gene copy number, should correlate with substrate quantity in the diet. To test the AMH and reveal some of the genetics of herbivory vs carnivory, we sequenced, assembled, and annotated the genome of Anoplarchus purpurescens, a carnivorous prickleback fish in the family Stichaeidae, and compared the gene copy number for key digestive enzymes to that of Cebidichthys violaceus, a herbivorous fish from the same family. A highly contiguous genome assembly of high quality (N50 = 10.6 Mb) was produced for A. purpurescens, using combined long-read and short-read technology, with an estimated 33,842 protein-coding genes. The digestive enzymes that we examined include pancreatic α-amylase, carboxyl ester lipase, alanyl aminopeptidase, trypsin, and chymotrypsin. Anoplarchus purpurescens had fewer copies of pancreatic α-amylase (carbohydrate digestion) than C. violaceus (1 vs. 3 copies). Moreover, A. purpurescens had one fewer copy of carboxyl ester lipase (plant lipid digestion) than C. violaceus (4 vs. 5). We observed an expansion in copy number for several protein digestion genes in A. purpurescens compared to C. violaceus, including trypsin (5 vs. 3) and total aminopeptidases (6 vs. 5). Collectively, these genomic differences coincide with measured digestive enzyme activities (phenotypes) in the two species and they support the AMH. Moreover, this genomic resource is now available to better understand fish biology and dietary specialization.
Surgical treatment of fracture sequelae of the proximal humerus according to a pathology-based modification of the Boileau classification results in improved clinical outcome after shoulder arthroplasty
Authors: Kimmeyer Michael , Schmalzl Jonas , Schmidt Evelin , Graf Annika , Rentschler Verena , Gerhardt Christian , Lehmann Lars-Johannes 
Published: September 2023

Abstract
Background
Fracture sequelae of the proximal humerus were classified by Boileau into four types. Since there are pathomorphological differences and specific characteristics within the four types, we have developed a subclassification. For elderly patients, shoulder arthroplasty is mostly recommended. Based on the available literature and clinical trial results, a subclassification could be created that suggests a specific therapy for each subgroup. The aim of this study was to evaluate the endoprosthetic therapy according to the proposed subclassification and to provide an overview of the clinical and radiological results after endoprosthetic treatment of proximal humerus fracture sequelae.

Methods
Patients with fracture sequelae of the proximal humerus who underwent arthroplasty according to the suggestion of the subclassification were included. Minimum time to follow-up was twelve months. General condition and several specific shoulder scores as the Constant–Murley Score (CS) were recorded at the follow-up examination. Complication and revision rates were analyzed.

Results
In total, 59 patients (72.6 ± 10.0 years, 47 females, 12 males) were included. Mean follow-up time was 31.3 ± 17.0 months. Reverse shoulder arthroplasty was performed in 49 patients and anatomic shoulder arthroplasty was performed in ten patients. The CS increased by 47.3 points from preoperative (15.0) to postoperative (62.3). Good or very good clinical results were seen in 61% of the patients. Complications were observed in twelve (20%) patients and revision surgery was performed in nine (15%) patients.

Conclusion
Due to of the variety of fracture sequelae of the proximal humerus, a modification of the Boileau classification seems necessary. This study shows that endoprosthetic treatment for fracture sequelae can significantly improve the shoulder function in elderly patients. Good clinical results can be achieved with a comparatively low revision rate following the treatment suggestions of the proposed subclassification of the Boileau classification.

Level of evidence IV
Case series.
Serum metabolomics study of narcolepsy type 1 based on ultra-performance liquid chromatography–tandem mass spectrometry
Authors: Zhan Qingqing , Wang Lili , Liu Nan , Yuan Yuqing , Deng Liying , Ding Yongmin , Wang Fen , Zhou Jian , Xie Liang 
Published: September 2023

AbstractNarcolepsy is a chronic and underrecognized sleep disorder characterized by excessive daytime sleepiness and cataplexy. Furthermore, narcolepsy type 1 (NT1) has serious negative impacts on an individual's health, society, and the economy. Currently, many sleep centers lack the means to measure orexin levels in the cerebrospinal fluid. We aimed to analyze the characteristics of metabolite changes in patients with NT1, measured by ultra-performance liquid chromatography–tandem mass spectrometry. A principal component analysis (PCA), an orthogonal partial least square discriminant analysis (OPLS-DA), t tests, and volcano plots were used to construct a model of abnormal metabolic pathways in narcolepsy. We identified molecular changes in serum specimens from narcolepsy patients and compared them with control groups, including dehydroepiandrosterone, epinephrine, N-methyl-D-aspartic acid, and other metabolites, based on an OPLS-loading plot analysis. Nine metabolites yielded an area under the receiver operating curve > 0.75. Meanwhile, seven abnormal metabolic pathways were correlated with differential metabolites, such as metabolic pathways; neuroactive ligand‒receptor interaction; and glycine, serine, and threonine metabolism. To our knowledge, this is the first study to reveal the characteristic metabolite changes in sera from NT1 patients for the selection of potential blood biomarkers and the elucidation of NT1 pathogenesis.
LncRNA expression signature identified using genome-wide transcriptomic profiling to predict lymph node metastasis in patients with stage T1 and T2 gastric cancer
Authors: Dong Zhe-bin , Xiang Han-ting , Wu Heng-miao , Cai Xian-lei , Chen Zheng-wei , Chen Sang-sang , He Yi-Chen , Li Hong , Yu Wei-ming , Liang Chao 
Published: September 2023

Abstract
Background
Lymph node (LN) status is vital to evaluate the curative potential of relatively early gastric cancer (GC; T1–T2) treatment (endoscopic or surgery). Currently, there is a lack of robust and convenient methods to identify LN metastasis before therapeutic decision-making.

Methods
Genome-wide expression profiles of long noncoding RNA (lncRNA) in primary T1 gastric cancer data from The Cancer Genome Atlas (TCGA) was used to identify lncRNA expression signature capable of detecting LN metastasis of GC and establish a 10-lncRNA risk-prediction model based on deep learning. The performance of the lncRNA panel in diagnosing LN metastasis was evaluated both in silico and clinical validation methods. In silico validation was conducted using TCGA and Asian Cancer Research Group (ACRG) datasets. Clinical validation was performed on T1 and T2 patients, and the panel’s efficacy was compared with that of traditional tumor markers and computed tomography (CT) scans.

Results
Profiling of genome-wide RNA expression identified a panel of lncRNA to predict LN metastasis in T1 stage gastric cancer (AUC = 0.961). A 10-lncRNA risk-prediction model was then constructed, which was validated successfully in T1 and T2 datasets (TCGA, AUC = 0.852; ACRG, AUC = 0.834). Thereafter, the clinical performance of the lncRNA panel was validated in clinical cohorts (T1, AUC = 0.812; T2, AUC = 0.805; T1 + T2, AUC = 0.764). Notably, the panel demonstrated significantly better performance compared with CT and traditional tumor markers.

Conclusions
The novel 10-lncRNA could diagnose LN metastasis robustly in relatively early gastric cancer (T1–T2), with promising clinical potential.
Applying the Theoretical Domains Framework to Develop an Intervention to ‘Re-implement’ Parent–Child Interaction Therapy (PCIT)
Authors: Woodfield Melanie J. , Phillips Sharon T. , Cargo Tania , Merry Sally N. , McNeil Cheryl B. , Hetrick Sarah E. 
Published: September 2023

AbstractParent–Child Interaction Therapy (PCIT) is an empirically supported treatment for childhood conduct problems, with increasing numbers of clinicians being trained in Aotearoa/New Zealand. However, ensuring sustained delivery of effective treatments by trained clinicians in routine care environments is notoriously challenging. The aims of this qualitative study were to (1) systematically examine and prioritise PCIT implementation barriers and facilitators, and (2) develop a well specified and theory-driven ‘re-implementation’ intervention to support already-trained clinicians to resume or increase their implementation of PCIT. To triangulate and refine existing understanding of PCIT implementation determinants from an earlier cross-sectional survey, we integrated previously unanalysed qualitative survey data (54 respondents; response rate 60%) with qualitative data from six new focus groups with 15 PCIT-trained clinicians and managers in Aotearoa/New Zealand. We deductively coded data, using a directed content analysis process and the Theoretical Domains Framework, resulting in the identification of salient theoretical domains and belief statements within these. We then used the Theory and Techniques Tool to identify behaviour change techniques, possible intervention components, and their hypothesised mechanisms of action. Eight of the 14 theoretical domains were identified as influential on PCIT-trained clinician implementation behaviour (Knowledge; Social/Professional Role and Identity; Beliefs about Capabilities; Beliefs about Consequences; Memory, Attention and Decision Processes; Environmental Context and Resources; Social Influences; Emotion). Two of these appeared to be particularly salient: (1) ‘Environmental Context and Resources’, specifically lacking suitable PCIT equipment, with (lack of) access to a well-equipped clinic room appearing to influence implementation behaviour in several ways. (2) ‘Social/Professional Role and Identity’, with beliefs relating to a perception that colleagues view time-out as harmful to children, concerns that internationally-developed PCIT is not suitable for non-Māori clinicians to deliver to Indigenous Māori families, and clinicians feeling obligated yet isolated in their advocacy for PCIT delivery. In conclusion, where initial implementation has stalled or languished, re-implementation may be possible, and makes good sense, both fiscally and practically. This study suggests that re-implementation of PCIT in Aotearoa/New Zealand may be facilitated by intervention components such as ensuring access to a colleague or co-worker who is supportive of PCIT delivery, access to suitable equipment (particularly a time-out room), and targeted additional training for clinicians relating to the safety of time-out for children. The feasibility and acceptability of these intervention components will be tested in a future clinical trial.
Post-fire soil emissions of nitric oxide (NO) and nitrous oxide (N2O) across global ecosystems: a review
Authors: Stephens Elizah Z. , Homyak Peter M. 
Published: September 2023

AbstractWildfires may increase soil emissions of trace nitrogen (N) gases like nitric oxide (NO) and nitrous oxide (N2O) by changing soil physicochemical conditions and altering microbial processes like nitrification and denitrification. When 34 studies were synthesized, we found a significant increase in both NO and N2O emissions up to 1 year post-fire across studies spanning ecosystems globally. However, when fluxes were separated by ecosystem type, we found that individual ecosystem types responded uniquely to fire. Forest soils tended to emit more N2O after fire, but there was no significant effect on NO. Shrubland soils showed significant increases in both NO and N2O emissions after fires; often with extremely large but short-lived NO pulses occurring immediately after fire. Grassland NO emissions increased after fire, but the size of this effect was small relative to shrublands. N2O emissions from burned grasslands were highly variable with no significant effect. To better understand the variation in responses to fire across global ecosystems, more consistent measurements of variables recognized as important controls on soil fluxes of NO and N2O (e.g., N cycling rates, soil water content, pH, and substrate availability) are needed across studies. We also suggest that fire-specific elements like burn severity, microbial community succession, and the presence of char be considered by future studies. Our synthesis suggests that fires can exacerbate ecosystem N loss long after they burn, increasing soil emissions of NO and N2O with implications for ecosystem N loss, climate, and regional air quality as wildfires increase globally.