bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evolutionary analysis of conserved non-coding elements subsequent to whole-genome duplication in opium poppy
Authors: Xu Yu , Bush Stephen J. , Yang Xinyi , Xu Linfeng , Wang Bo , Ye Kai 
Published: May 2023

AbstractWhole-genome duplication (WGD) leads to the duplication of both coding and non-coding sequences within an organism’s genome, providing an abundant supply of genetic material that can drive evolution, ultimately contributing to plant adaptation and speciation. Although non-coding sequences contain numerous regulatory elements, they have been understudied compared to coding sequences. In order to address this gap, we explored the evolutionary patterns of regulatory sequences, coding sequences, and transcriptomes using conserved non-coding elements (CNEs) as regulatory element proxies following the recent WGD event in opium poppy (Papaver somniferum). Our results showed similar evolutionary patterns in subgenomes of regulatory and coding sequences. Specifically, the biased or unbiased retention of coding sequences reflected the same pattern as retention levels in regulatory sequences. Further, the divergence of gene expression patterns mediated by regulatory element variations occurred at a more rapid pace than that of gene coding sequences. However, gene losses were purportedly dependent on relaxed selection pressure in coding sequences. Specifically, the rapid evolution of tissue-specific benzylisoquinoline alkaloids production inP. somniferumwas associated with regulatory element changes. The origin of a novel stem-specific ACR, which utilized ancestral cis-elements as templates, is likely to be linked to the evolutionary trajectory behind the transition of thePSMT1-CYP719A21cluster from high levels of expression solely inP. rhoeasroot tissue to its elevated expression inP. somniferumstem tissue. Our findings demonstrate that rapid regulatory element evolution can contribute to the emergence of new phenotypes and provide valuable insights into the high evolvability of regulatory elements.Significance StatementThis study demonstrates that rapid evolution of regulatory elements can drive the emergence of novel phenotypes in plants. Our investigation, in particular, revealed that the evolution of stem-specific high expression patterns of BIAs genes inP. somniferumwas linked to rapid changes in regulatory elements.
Optogenetic inhibition of Gα signalling alters and regulates circuit functionality and early circuit formation
Authors: Lockyer Jayde , Reading Andrew , Vicenzi Silvia , Delandre Caroline , Marshall Owen , Gasperini Robert , Foa Lisa , Lin John Y. 
Published: May 2023

AbstractOptogenetic techniques provide genetically targeted, spatially and temporally precise approaches to correlate cellular activities and physiological outcomes. In the nervous system, G-protein-coupled receptors (GPCRs) have essential neuromodulatory functions through binding extracellular ligands to induce intracellular signaling cascades. In this work, we develop and validate a new optogenetic tool that disrupt Gαqsignaling through membrane recruitment of a minimal Regulator of G-protein signaling (RGS) domain. This approach,Photo-inducedModulation ofGα protein –Inhibition of Gαq(PiGM-Iq), exhibited potent and selective inhibition of Gαqsignaling. We alter the behavior ofC. elegansandDrosophilawith outcomes consistent with GPCR-Gαqdisruption. PiGM-Iq also changes axon guidance in culture dorsal root ganglia neurons in response to serotonin. PiGM-Iq activation leads to developmental deficits in zebrafish embryos and larvae resulting in altered neuronal wiring and behavior. By altering the choice of minimal RGS domain, we also show that this approach is amenable to Gαisignaling.
Epigenetic information loss is a common feature of multiple diseases and aging
Authors: Sagy Naor , Chang Chieh , Gal Maayan , Bar Daniel Z 
Published: May 2023

AbstractAging is a major risk factor for a plethora of diseases. The information theory of aging posits that epigenetic information loss is a principal driver of the aging process. Despite this, the connection between epigenetic information loss and disease has not been thoroughly investigated. Here, we analyzed tissue-unique methylation patterns in healthy and diseased organs, revealing that for several diseases these patterns degrade, regressing to a mean form. We interpret this as epigenetic information loss, where tissue-unique patterns erode. Information loss is not limited to diseases. Age-related erosion of unique methylation patterns was observed in some tissues and cells, while other tissues and cells diverged away from the mean. Our findings demonstrate that analyzing methylation patterns in tissue-unique sites can effectively distinguish between patients and healthy controls across a range of diseases, and underscore the role of epigenetic information loss as a common feature in various pathological conditions.Abstract FigureGraphical abstractTissue unique methylation pattern regress toward the mean upon disease.A single methylation site, showing low methylation in the liver and high in every other tissue, becomes more methylated in diseased livers.
Analysis of losses in the high-speed PM BLDC motor with open slot stator core made of amorphous soft magnetic material
Authors: Hreczka Marek , Kolano Roman , Kolano-Burian Aleksandra , Burlikowski Wojciech , Hetmańczyk Janusz 
Published: May 2023

Purpose
The purpose of this paper is to verify results related to losses in the core of a brushless DC prototype motor, obtained using its computer FE models, by experimental tests on manufactured machines. The paper focuses on the comparison of losses in the core of a machine with a classical stator core made of an iron–silicon material (Fe–Si) and a new one made of a modern METGLAS material.

Design/methodology/approach
Computer models of the prototype motors were created using FEM. The designed machines were manufactured, and experimental tests were performed. To achieve high frequencies in rotating magnetic fields, motors with a stator to rotor pole ratio of 9/12 were built. Twin rotor approach was applied, as two identical rotors were built along the two geometrically identical stators made of different core materials.

Findings
Experimental studies have shown the superiority of the METGLAS material over the classical Fe–Si material. Material parameters were measured directly on the prepared cores as library data used in the simulation may be incorrect due to technological processes during core production, which was also verified. Problems related to twin rotor approach have been identified. Solution to the problem has been suggested. Necessity of 3D FEM modelling was identified.

Originality/value
The main source of originality is that METGLAS material used in the prototype machines was developed and manufactured by the authors themselves. Original approach to core parameter evaluation based on simplified methodology has been suggested. Another original part is a simplified methodology applied to loss measurement during no-load test.
A multisite study of amphetamine use disorders, length of detention and readmission in rural jails
Authors: Gamble Taylor M. , Kopak Al , Hoffmann Norman 
Published: May 2023

Purpose
Most people admitted to jails present indications of substance use disorder, and methamphetamine use disorders (MUDs) have recently become the most prevalent in certain communities. Much of the research conducted with jail populations has focused on large urban facilities, despite them representing a small number of the nearly 3,000 correctional centers in the USA. This study aims to examine MUDs in a large multisite sample of adults admitted to rural jails in the USA to help inform better practices aimed at addressing these conditions.

Design/methodology/approach
Interviews were conducted with 525 adults ranging in age from 18 to 72 years within three rural detention centers within the USA using the Comprehensive Addictions and Psychological Evaluation-5. Retrospective records were extracted to assess relationships between Diagnostic and Statistical Manual of Mental Disorders diagnostic classifications for MUDs, length of detention and jail admission over a 12-month period.

Findings
Results indicate those who met diagnostic criteria for MUD were more likely to be charged with a drug-related offense, a more serious offense (i.e. felony) and also spend more time detained relative to those who did not receive a similar diagnosis. Multivariate regression analyses also demonstrated persons with MUD diagnoses were significantly more likely to be admitted to the detention center on multiple occasions compared to those without a diagnosis.

Originality/value
Evidence from an understudied population supports the need to address MUDs among adults detained in rural jails. Proper diagnosis and linkage to care can enhance efforts to reduce the prevalence of these conditions.
Haikou restaurant: the entrepreneur's dilemma in the new normal
Authors: Rishi Bikramjit , Sharma Soni 
Published: May 2023

Learning outcomes
The purpose of this paper is to understand a new restaurant venture's target segment and create a consumer profile for the new restaurant; to design a positioning statement for the new restaurant; to appraise the marketing strategy and suggest improvements in the marketing mix of a new restaurant venture in the new normal; to discuss the augmentation of services by a new restaurant to compete effectively in the market; and to identify and discuss the vital marketing steps for opening a restaurant in the new normal.

Case overview/synopsis
Kelvin, an ambitious and budding restaurateur, had high aspirations with great plans. V café was his first running venture. The income from V café was not enough to improve his social position. He wanted to open a new restaurant (Haikou) and earn more. Kelvin was well aware of COVID-19's current condition and its severe implications for the restaurant business. He did not have any experience in marketing a restaurant. So he was puzzled about understanding the target segment, positioning and marketing mix of the proposed restaurant in the new normal.

Complexity academic level
The case will cater to business management students pursuing a postgraduate management program. The case can be applied in Marketing Management, Entrepreneurship, Hospitality Management and Services Marketing courses. The prerequisite for this case is a basic understanding of marketing concepts.

Supplementary materials
Supplementary materials teaching notes are available for educators only.

Subject code
CSS 8: Marketing
Zakat as an instrument of poverty reduction in Indonesia
Authors: Herianingrum Sri , Supriani Indri , Sukmana Raditya , Effendie Effendie , Widiastuti Tika , Fauzi Qudsi , Shofawati Atina 
Published: May 2023

Purpose
This study aims to analyze the concept of Zakat as an instrument to increase the economy and poverty eradication in Indonesia.

Design/methodology/approach
This study used a qualitative method based on library research sourced from books, financial reports and another previous research.

Findings
The results show that the empowerment programs conducted by Zakat institutions in Indonesia are based on the scale of priorities and the potential of Mustahik. Zakat management considers the level of productivity and long-term impacts that improve Mustahik Economy. Thus, the empowerment programs lead to the reduction of Mustahik living below poverty line.

Research limitations/implications
This study contributes in two ways: first, it analyzes a model to identify the Mustahik’s potential for the Zakat institution in Indonesia. Second, it encourages the awareness of Muzakki and Mustahik regarding the role of Zakat in the Indonesian economy. This is expected to prompt their level of participation in optimizing the potential of Zakat in Indonesia.

Originality/value
Given the scarce literature that provide qualitative and critical reviews of the implementation Zakat empowerment programs to alleviate poverty conducted by the Zakat institutions in Indonesia, this research can act as a bridge for future research in performing empirical studies regarding the impact of a Zakat empowerment program on society.
A knowledge-based perspective on the professionalization of SMEs: a systematic literature review and future research directions
Authors: Mariano Stefania 
Published: May 2023

Purpose
This paper aims to provide a synthesis of theoretical and empirical work related to the professionalization of small- and medium-sized enterprises (SMEs) from a knowledge-based perspective.

Design/methodology/approach
A systematic literature review consisting of three major steps of planning, conducting and reporting is conducted. Papers are identified, selected and deductively coded. Quantitative and qualitative methods are used to analyze the papers. The finalized list includes 78 papers and 48 journals, with the oldest paper published in 1980 and the most recent papers published in 2022.

Findings
The findings showed that the empirical works (n = 69) outnumbered the conceptual works (n = 9). Most papers focused on the organizational level of analysis and identified causal conditions, modes, intervening conditions and consequences. A multidimensional characteristic of professionalization emerged inductively as an additional attribute.

Originality/value
This paper provides a synthesis of the current literature and offers a research agenda to academics and practitioners interested in the professionalization of SMEs from a knowledge-based perspective.
Development of Respect for Differences Scale for middle school students: validity and reliability study
Authors: Gülüm Başak , Türker İbrahim Halil 
Published: May 2023

Purpose
The purpose of this study is to develop a valid and reliable scale that can measure the level of respect for differences of middle school students. The validity and reliability studies of the scale draft prepared as a result of the opinions received were carried out on 964 middle school students.

Design/methodology/approach
The sequential exploratory mixed method was used. In the study, attitude items were created by examining the studies in the literature with qualitative methods, and the scale was then finalized by applying tests for the attitude scale prepared with quantitative methods.

Findings
As a result of the exploratory factor analysis made on the data obtained, a structure consisting of 20 items and four factors as “gender”, “disability status”, “physical appearance” and “cultural identity” were reached. Also, it was seen that the scale identified 56% of the total variance. Confirmatory factor analysis that was performed on another sample showed that the sample fit of the scale was at an acceptable level. The reliability coefficient of the scale was calculated as Cronbach’s α = 0.815; composite reliability was ranged between 0.766 and 0.894 and the internal consistency of the scale was quite high. It was concluded that the scale developed to determine the level of respect for differences is a valid and reliable measurement tool.

Originality/value
This study is considered significant in terms of presenting a valid and reliable scale that will reveal the attitudes of middle school students towards differences in the literature.
How to incorporate artificial intelligence (AI) into your library workflow
Authors: Pival Paul R. 
Published: May 2023

Purpose
This paper aims to highlight the recent developments in artificially intelligent chatbots and how the resulting tools can be incorporated into the daily workflow of library work.

Design/methodology/approach
Recent literature is examined, parallels to librarian reactions to the birth of the original internet search engines are drawn and suggestions for the use of specific tools for specific tasks are given.

Findings
Although effectively less than 6 months old, the field of artificial intelligence (AI) chatbots is already fulsome enough to be able to be usefully incorporated into the profession. More tools are imminent, though each of them does and will continue to have shortcomings of which informational professionals need to be aware.

Practical implications
This paper provides practical suggestions and specific tools to incorporate into the workflow of different library specialties, along with important caveats for quality and bias.

Social implications
The public has adopted the use of AI chatbots faster than any previously introduced technology. Librarians have a history of moving more slowly when it comes to the core values of the profession, such as information searching. It is vital for information professionals, such as librarians, to understand both the value and the pitfalls of these tools to be able to work with patrons and stay relevant in the eyes of the public and institutional funders.

Originality/value
This paper fills a need for practical advice in using AI to perform daily library work.
Mental health of Indian LGBT+ community: role of coping self-efficacy and social inclusion
Authors: Parwani Sanjana , Talukdar Asim Kumar 
Published: May 2023

Purpose
The sexual minority groups in India seem to be suffering from continued social exclusion affecting their mental health. This study aims to investigate the effect of the hostile attitude of society and lack of social support on the mental health of the Indian LGBT+ members.

Design/methodology/approach
Hypotheses were developed by drawing theories and concepts from the literature and were tested using the partial least square–structural equation model with a sample size of 151 of the Indian LGBT+ community.

Findings
The findings showed a strong negative effect of the hostile attitude of society on the mental health of the Indian LGBT+ community. The findings further showed that weak problem-focused and emotion-focused coping self-efficacy negatively mediated the relationship between the hostile attitude of society and mental health, while lack of social support negatively moderated the relationship between the hostile attitude of society and both problem-focused and emotion-focused coping self-efficacy of the Indian LGBT+ community.

Originality/value
This study makes a novel and significant theoretical contribution by investigating the effect of the hostile attitude of society and the lack of social support on the mental health of the Indian LGBT+ community members. This study also makes a significant practical contribution in underpinning the urgent need for social inclusion and support to improve the mental health of Indian LGBT+ community members, which is currently in dire condition.
Application of blockchain in enterprise financing: literature review and knowledge framework
Authors: Song Hua , Yang Yudong , Tao Zheng 
Published: May 2023

Purpose
In recent years, the application of blockchain in enterprise financing has become a hot topic in academic research. This study aims to review the existing literature, construct a knowledge framework for this research topic and propose an agenda for future research.

Design/methodology/approach
Based on 181 papers published from 2016 to 2020 in core journal databases in China and abroad, this study used bibliometric tools to identify and analyze an overview of literature publications, research hotspot trends and research theme clustering. This study also qualitatively analyzes literature from the dimensions of enabling mechanisms, multitechnology synergy, challenges, theoretical perspectives and research methods.

Findings
This study presents the research progress of blockchain applications in direct financing, bank credit, supply chain finance and other financing modes and analyzes the similarities and differences between domestic and international literature. This study also reveals enabling mechanisms of blockchain in enterprise financing, reflected as information quality improvement (data elements), trust mechanism innovation (business process) and collaboration structure enhancement (network structure). The study found several challenges (e.g. technological uncertainty, data security and organizational change) and trends (e.g. integrated innovation of multiple digital technologies). Additionally, the authors identified several gaps and opportunities for further research.

Research limitations/implications
This study adopts a strict strategy of selecting search terms when retrieving the literature, leading to the exclusion of certain papers on this topic.

Practical implications
This study provides valuable insights into the innovative development of enterprise financing modes enabled by blockchain and emphasizes that managers should clarify the applicable boundaries and necessary conditions of blockchain innovation in different financing scenarios to match technological innovation with industrial expectations.

Originality/value
This study constructs a knowledge framework on this topic based on a comprehensive review of existing research and proposes several important issues for future research based on the identified research gaps.
Determining the relationship between diet inflammatory index, mental status and quality of life in type 2 diabetes: a cross-sectional study
Authors: Guldali Merve , Guveli Hakan , Cetin Ferhat , Kenger Emre Batuhan , Ozlu Tugce , Ergun Can 
Published: May 2023

Purpose
Diabetes is one of the health problems of increasing importance owing to the increase in its incidence and the problems it causes, and it is closely related to nutrition. This study aims to determine the relationship between the dietary inflammatory index (DII) scores of individuals with type 2 diabetes, depression, anxiety and quality of life.

Design/methodology/approach
In this cross-sectional study, 158 individuals with type 2 diabetes who applied to a nutrition and diet outpatient clinic of a private hospital in Istanbul were included. Their depression status was evaluated using the Beck Depression Inventory; their anxiety status was evaluated using the Beck Anxiety Inventory; and their quality of life was evaluated using the Short Form 36 Quality of Life scale. One-way ANOVA test was used to define the difference between groups. All test results were evaluated at a significance level of 0.05.

Findings
There was no significant relationship between DII scores, depression (p = 0.814) and anxiety (p = 0.817). However, a significant decrease was observed in the scores of the quality of life criterion in the groups with high depression and anxiety scores (p < 0.05). In addition, participants with high anxiety states had higher HbA1c levels (p = 0.043).

Originality/value
Individuals in this sample with no known psychiatric diagnosis or treatment history demonstrated a significant relationship between depression and anxiety scores and quality of life.