bluuebunny/crossref_metadata_2025_split huggingface dataset:
Study on the efficacy of furosemide nebulization in transient tachypnea of newborn – A case–control study
Authors: Kaivalya A. , Gobbur R. H. , Shettar S. S. Kalyan , Patil M. M. 
Published: January 2025

Abstract

OBJECTIVE:
This study compares the efficacy of furosemide nebulization versus normal saline nebulization in treating transient tachypnea of the newborn (TTN).

METHODS:
A prospective case-control study was conducted on 100 neonates diagnosed with TTN, who were randomly assigned to two groups. Group A received furosemide nebulization, while Group B received saline nebulization. The neonates were monitored for oxygen requirement, NICU stay, breastfeeding initiation, weight loss, and other clinical outcomes.

RESULTS:
Furosemide nebulization resulted in a significantly shorter NICU stay, reduced oxygen requirement, and earlier initiation of breastfeeding compared to saline nebulization. Both groups had a 100% discharge rate, with no adverse effects observed in either group.

CONCLUSION:
Furosemide nebulization is a safe and effective treatment for TTN, offering superior outcomes in terms of oxygen therapy reduction, faster recovery, and shorter NICU stays compared to normal saline nebulization.
Challenges faced during antitubercular therapy
Authors: Likhitha B. K. , Anjutagi Shreeshail , Kulkarni Keertivardhan D. , Mahawar Madhav 
Published: January 2025

Abstract
This case report discusses regarding a 48-year-old male with drug-sensitive tuberculosis (TB) and alcoholic liver disease, who experienced significant side effects during antitubercular therapy. The patient presented with peripheral neuropathy, deranged liver function, elevated uric acid levels, gastritis, and psychological distress during the treatment period. Modifications included the change of regimen and the symptomatic treatment of the associated side effects with regular liver function monitoring. Comprehensive patient education and counseling were provided to enhance adherence to the treatment. After the completion of therapy, the patient showed near complete resolution in chest X-ray with the remission of symptoms. This case emphasizes the importance of tailored management to address the challenges during the therapy and ensure successful TB treatment outcomes.
Role of soluble triggering receptor expressed on myeloid cells-1 and serum procalcitonin in exacerbation of chronic obstructive pulmonary disease
Authors: Okaily Nagwa I. , Foley Rehab R. , Abd Elhakeem Mohammed A. , Kasem Ahmed H. , Ismail Doaa E. 
Published: January 2025

Background
The morbidity, mortality, and quality of life of people with chronic obstructive pulmonary disease (COPD) are significantly impacted by exacerbations. Soluble triggering receptor expressed on myeloid cells-1 (sTREM-1), which act as an amplifier of the innate immune response, procalcitonin (PCT) is a polypeptide that normally produced by para follicular cells (C cells) of the thyroid and by neuroendocrine cells of the lung and intestine could be used to determine the severity of inflammation.

Objective
The aim of this study was to assess levels of sTREM-1 and PCT in COPD and evaluate the role of them in diagnosis of acute exacerbation of COPD (AECOPD) due to bacterial infections.

Patients and methods
The study was conducted on 60 individuals divided into group I (exacerbation group): included 20 patients. Group II (stable COPD group): included 20 patients. Group III (control group): included 20 individuals, apparently healthy and matched for age and sex. Assessment of sTREM-1 and serum PCT levels by enzyme-linked immunosorbent assay in addition to complete blood count, erythrocyte sedimentation rate, renal function tests, C-reactive protein, and sputum culture.

Results
sTREM-1, PCT, and neutrophil/lymphocyte ratio (NLR) were higher in the AECOPD group than in other groups. In AECOPD: the result of sputum cultures revealed; 65% Gram-negative bacteria and 35% Gram-positive bacteria, while in stable COPD: the growth of normal upper respiratory tract flora is 65% then Gram-positive bacteria (20%) then Gram-negative bacteria (15%). PCT, sTREM-1, and NLR showed a higher level in patients who had Gram-negative infection than those with Gram-positive infection, and the lowest level in those who showed growth of normal flora. Pseudomonas is the most commone causative organism of exacerbated COPD (35%), followed by Staphylococcus aureus (25%).

Conclusion
sTREM-1, NLR, and PCT level can be considered as an appropriate diagnostic marker in patients with exacerbated COPD due to bacterial infection and in differentiating them from stable COPD patients and may be used to guide medication and target management in patients with AECOPD.
Bronchial asthma control and severity concerning allergen sensitization patterns
Authors: Abdelwahab Heba W. , Abdelmoati Heba N , Yousef Aida M. , Abdelhafez Sayed A. , Elhosiny Mahmoud M. 
Published: January 2025

Introduction
Allergic asthma is considered the most common phenotype of asthma, which is characterized by immunoglobulin E sensitization to aeroallergens. The association between allergic sensitization to aeroallergens and asthma severity and control has been evaluated in a few studies. This study aimed to evaluate the relationship between aeroallergen sensitization patterns and both Bronchial asthma (BA) control and severity.

Materials and methods
A cross-sectional study was conducted on BA patients attending allergy and immunotherapy clinics. A skin prick test was performed as per clinical indication. BA control and severity were assessed according to GINA guideline 2021.

Results
The study included 100 BA patients. The most common allergens to which the patients were sensitized were mites (74%), followed by molds (70%). There was no statistically significant association between allergen sensitization patterns and BA severity. There was also no statistically significant association between allergen sensitization patterns and BA level of control. However, there was a significant association between the duration of BA and its severity or control (P<0.001 for both).

Conclusion
Allergen sensitivity is a common feature of asthma. House dust mites and molds were the common allergen sensitization identified in BA patients. Atopy is not the primary underlying cause of uncontrolled or severe bronchial asthma.
Early effects of hemodialysis on pulmonary function in patients with end-stage renal disease
Authors: Youssef Shaimaa M.A. , Okab Ali A. , Mahmoud Azza M. , Mohammed Etemad A.E. 
Published: January 2025

Background
Patients with end-stage renal disease (ESRD) often develop various health complications, including pulmonary dysfunction. Hemodialysis (HD) is a common treatment for these patients, but its effects on pulmonary function remain an area of investigation. This study aimed to assess the impact of HD on spirometry parameters in ESRD patients.

Patients and methods
This prospective study was carried out on 60 patients with ESRD on HD. Spirometry parameters, including vital capacity (VC), forced vital capacity (FVC), forced expiratory volume in the first second (FEV1), FEV1/FVC ratio, peak expiratory flow (PEF), and forced expiratory flow between 25 and 75% of FVC (FEF 25–75%), were measured 1 h before and after HD.

Results
After HD, significant improvements were observed in several spirometry parameters. The median % change in VC was 9.92% (range, −27.05 to 47.66%), in FVC% was 11.68% (range, −16.5 to 47.37%), in FEV1% was 12.56% (range, −2 to 49.43%), in FEV1/FVC was 1.52% (range, −9.39 to 17.32%), in PEF% was 14.86% (range, −15.33 to 131.73%), and in FEF 25–75% was 13.89% (range, −14.29 to 97.56%).

Conclusions
In ESRD patients, pulmonary abnormalities, primarily restrictive and mixed disorders, were common. Spirometry parameters (FVC, FEV1, PEF rate) were often below normal. However, HD led to notable improvements in VC, FVC, FEV1, FEV1/FVC, FEF 25–75%, PEF rate, and arterial blood gases parameters (pH, CO2, HCO3, SO2).
БОЛЕЗНЬ АЛЬЦГЕЙМЕРА: ДОЛГИЙ ПУТЬ К УДАЧНОМУ «ХОДУ» В ЛЕЧЕНИИ
Authors: Сафроненко А.В. , Ганцгорн Е.В. , Погребняк А.В. , Рашкова Е.В. , Стумайтис Т.С. , Ващенко Д.И. , Пегливанов С.С. 
Published: January 2025

Болезнь Альцгеймера (БА) – один из самых распространенных типов деменции, который возникает у пожилых (как правило, старше 65 лет). Средняя продолжительность жизни пациентов с момента проявления первых клинических симптомов БА составляет приблизительно 8–10 лет. При этом, несмотря на открытия, оказавшие положительное влияние на лечение БА, к сожалению, стопроцентно эффективное лекарственное средство, которое могло бы спасти миллионы людей от деменции, до сих пор не найдено. Задачей представленного обзора является анализ последовательного развития подходов к фармакотерапии данного заболевания. Лечение БА эволюционировало от архаичных методов к современным терапевтическим стратегиям. Изучение патогенеза БА в рамках холинергической гипотезы обеспечило основу для разработки ее специфического лечения и внедрения в практику ингибиторов холинэстеразы. Дальнейшие исследования, основанные на амилоидной гипотезе, привели к разработке моноклональных антител, таких как адуканумаб, продемонстрировавших определенную эффективность в клинических испытаниях. Несмотря на прогресс, полное излечение БА остается нерешенной задачей, стимулирующей дальнейшие интенсивные исследования в данном направлении.
Alzheimer’s disease (AD) is one of the most common types of dementia that occurs in older adults, usually 65 years old. The average life expectancy of patients from the moment of the first clinical symptoms of this disease is approximately 8 to 10 years. At the same time, despite significant discoveries that have positively impacted treatment, a complete and effective drug that could save millions of lives from dementia has not yet been found. The aim of this review is to analyze the progression of therapy for this disease. The treatment of AD has evolved from archaic methods to modern therapeutic strategies. The study of the pathogenesis of AD within the framework of the cholinergic hypothesis provides the basis for the development of specific treatment of this disease and the introduction of anticholinesterase inhibitors into practice. Further research based on the amyloid hypothesis has led to the development of monoclonal antibodies, such as aducanumab, which have shown some efficacy in clinical trials. Despite this progress, a complete cure for AD remains an unresolved issue that continues to stimulate intensive research in this area.
ЗЕМСКОЕ АКУШЕРСТВО В РОССИЙСКОЙ ИМПЕРИИ
Authors: Леваков С.А. , Кавиладзе М.Г. , Князев С.А. , Манагадзе И.Д. 
Published: January 2025

Вопрос роли акушера занимал значительное место в земской медицинской практике в Российской империи середины XIX – начала XX века. Земскими врачами в условиях российской деревни впервые были исследованы факторы риска как для материнского, так и для детского здоровья. На охрану здоровья матери и ребенка была направлена работа по организации квалифицированной акушерской помощи, учреждению яслей-приютов, профилактике острых детских инфекций, поддержке грудного вскармливания, профилактике сиротства. При этом ряд земских медико-социальных программ (организация акушерских пунктов, яслей-приютов) оказались неэффективными. Более значительных успехов удалось добиться в деле профилактики острых детских инфекций, медицинского обеспечения учеников земских школ и детей-сирот. Многие инициативы земских врачей – поддержка грудного вскармливания, профилактика сиротства, массовая иммунизация – используются в современных системах охраны материнства и детства.
The role of the obstetrician occupied a significant place in zemstvo medical practice in the Russian Empire in the mid-19th – early 20th centuries. Zemstvo doctors were the first to study risk factors for both maternal and child health in the Russian village. The work on organizing qualified obstetric care, establishing crèches and shelters, preventing acute childhood infections, supporting breastfeeding, and preventing orphanhood was aimed at protecting the health of mothers and children. At the same time, a number of zemstvo medical and social programs (organization of obstetric centers, crèches and shelters) turned out to be ineffective. More significant successes were achieved in preventing acute childhood infections, medical care for students of zemstvo schools and orphans. Many initiatives of zemstvo doctors – support for breastfeeding, prevention of orphanhood, mass immunization – are used in modern systems of protecting mothers and children.
Las circunstancias culturales y el error sobre el matrimonio.
Authors: Barber Juan Damián Gandía 
Published: January 2025

En los archivos del Dicasterio para la Doctrina de la Fe se encuentran las dudas formuladas en diversas épocas sobre el matrimonio. Nos encontramos tres casos planteados desde territorios de misión, que están conectados tanto por la pregunta que se formulaba, como por la argumentación de los votos de los Consultores que, en los casos más recientes, se razonaba según los anteriores y se aconsejaba recurrir a las Instrucciones para ellos emanadas. Uno de ellos planteaba esta duda para los matrimonios entre los ortodoxos abisinios, mientras que los otros dos eran para los conyugios entre personas no bautizadas. En los tres se cuestionaba si se podían considerar nulos todos los matrimonios contraídos con la posibilidad de poderlos disolver con facilidad en el futuro, según la costumbre o ley del país. No siendo la primera vez que se planteaba tal duda al Dicasterio, podemos observar como la línea argumental se va repitiendo en los distintos votos y se va recurriendo a las mismas soluciones que se dieron para casos incluso más antiguos. Dentro de los diversos defectos de consentimiento que se formulan (simple error, condición puesta excluyendo la indisolubilidad de forma expresa), también se argumenta la posibilidad de la nulidad de estos matrimonios cuando se hubiera puesto como una condición implícita en el fuero interno, que hacía que la voluntad solo quisiera el matrimonio celebrado según las costumbres y leyes del país. Concurrían todo un conjunto de circunstancias, indicios y pruebas que, junto a la declaración jurada de los cónyuges, o uno de ellos, avalada por la investigación sobre su honestidad y veracidad, podían hacer que se alcanzase la certeza moral de la nulidad del concreto matrimonio. Se afrontaba de este modo aquello que se formularía en el c. 1099 del Código de Derecho Canónico como error intelectivo que determina la voluntad, aunque entonces no se denominase de este modo.
Estrategias Aplicadas durante la COVID-19: un referente para los agentes económicos en tiempos de crisis
Authors: Abad Varas Marcelo 
Published: January 2025

El propósito de esta investigación fue explorar estrategias de salida de la COVID implementadas por los agentes en procura de la reactivación económica, bajo la perspectiva de una cesta de estrategias disruptivas exitosas. E hito a replicar por los agentes económicos como estrategias de salida ante recesiones y crisis. El diseño de investigación implicó una revisión de literatura de artículos científicos indexados en bases de alto impacto. Determinándose que la acinesia fue la característica central de los agentes económicos ante la vigencia de la COVID-19. La confusión generada y ausencia de referentes llevó a la economía a adoptar estrategias de salida disruptivas repentizadas en un ambiente pávido. Existieron campos del conocimiento cuyas estrategias de salida generaron resultados alentadores, entre ellos la Ciencia Médica por medio de la vacuna contra la COVID-19. Además de su exitoso proceso de inoculación adscrito a estrategias innovadoras subyacentes a una coalición de naciones. Ciertas políticas públicas y gestiones en actividades económicas particulares han sido también loables.
Hubungan Minat Dengan Nilai Praktik Klinik Keperawatan Luka Mahasiswa Prodi Keperawatan Aceh Utara Poltekkes Kemenkes Aceh Tahun 2023
Authors: Taufiq Said , Fauzi M. Jamil , Sofiati Irwani 
Published: January 2025

Kejadian luka menyebabkan 7% kematian di seluruh dunia, angka ini diperkirakan masih terus bertambah. Selain itu, luka dan injuri mengakibatkan kira-kira 16% berkurangnya masa hidup karena kecacatan (Disability Adjusted Life Year/DALY). Kejadian tersebut, 12,8% diantaranya terjadi karena ketidaksengajaan dan 3,2% disebabkan luka karena kesengajaan. Salah satu faktor yang kuat mempengaruhi hasil belajar adalah minat terhadap objek yang dipelajari, individu yang kurang tertarik atau mungkin tidak memiliki minat, maka minat itu mungkin kurang kuat dan efisien untuk menekuni suatu proses pembelajaran. Minat terhadap suatu mata kuliah ditunjukkan dengan kemauan untuk meneliti, partisipasi yang energik, kecenderungan kesadaran dan kesadaran yang kuat, rasa dan kemauan yang luas untuk belajar secara aktif. Penelitian ini untuk melihat hubungan minat dengan nilai mata kuliah keperawatan luka pada mahasiswa. Penelitian dilakukan di Prodi Keperawatan Aceh Utara Poltekkes Kemenkes Aceh Kota Lhokseumawe. Desain penelitian menggunakan cross sectional desaign dengan teknik sampel jenuh sejumlah 54 orang. Pengumpulan data dilakukan dengan menyebarkan kuesioner langsung kepada responden menggunakan Google Form. Analisis data menggunakan uji Chi Square atau Fisher Exact Test dengan interval kepercayaan 95%. Hasil penelitian ada hubungan yang kuat antara minat dan nilai mata kuliah praktik klinik keperawatan luka.
Tipologia das personagens, pacto narrativo ambíguo e contiguidade de universos narrativos em Nocturno de Chile de Roberto Bolaño
Authors: Cavaliere Mauro 
Published: January 2025

A consagração do romance como género literário por excelência, desde o realismo do século XIX, habituou-nos à presença de personagens inventadas. A personagem referencial, habitual em muitos géneros literários desde a Antiguidade até ao Romantismo, sofre, durante um século, uma espécie de ocultação, de marginalização, de desaparecimento. Com a literatura pós-moderna, esta mesma personagem parece revitalizada, quando não protagonista, em vários subgéneros literários, incluindo o romance histórico pós-moderno, a autoficção, a história ficcionada, a biografia ficcionada, etc. Mesmo em romances de difícil atribuição genérica, o leitor depara-se com personagens cujos nomes denotam, ou talvez apenas evoquem, algo conhecido no universo extraliterário. Além disso, a tipologia das personagens pode revelar-se extremamente mais complexa, constando de uma variedade tipológica que vai muito mais para além das inventadas e referenciais. O romance que me proponho analisar aqui, Nocturno de Chile, de Roberto Bolaño, é um excelente exemplo da variedade tipológica das personagens. Neste sentido, depois de tentar propor uma taxonomia das mesmas, sugerirei algumas hipóteses interpretativas sobre algumas das opções onomásticas do autor e o questionamento das interpretações correntes sobre uma das personagens. As considerações conclusivas serão dedicadas a algumas reflexões sobre as repercussões que estas escolhas podem ter no pacto narrativo proposto neste romance e, de um modo mais geral, na literatura pós-moderna e nos seus subgéneros típicos.
“Reversed” New Historicism and the Latvian Literature: Gundega Repše’s Novels
Authors: Jansone Ilze 
Published: January 2025

The article1 offers an interpretation of Latvian writer Gundega Repše’s novels within their historical context by exploring interpretative possibilities of New Historicism. As a literary theory, New Historicism is an open and opaque methodology, inviting a playful engagement with methods, agencies, and interpretative strategies, and encouraging critical thinking within a theoretical discourse. I also propose that Repše’s novels might be read as a literary practice of what might be called “reversed” New Historicism by which I mean a particular method of creative writing that reinforces the correlation between history and literature and rhizomatic thinking. It helps to reveal systems and assumptions of power and comment on them from below, this way shaping new ways of how we think of fiction, history and language. In my interpretation, I demonstrate that “reversed” New Historicism as a method of creative writing encourages to rethink the continuous presence of power structure that still exists in contemporary society. A network of memories, displayed through artistic language, helps to see the present-day situation and the continuity of the past more clearly.
Rôle des pratiques parentales coercitives dans la continuité intergénérationnelle des comportements antisociaux
Authors: Blouin Sarah , Faucher Ève-Marie , Roy Rosemarie , Paradis Hélène , Aubé Sophie , Petitclerc Amélie 
Published: January 2025

Les comportements antisociaux peuvent se transmettre au fil des générations. Cette étude vise à identifier si les pratiques parentales coercitives jouent un rôle médiateur dans la continuité intergénérationnelle de ces comportements. L’échantillon, composé de 1515 familles, provient de l’Étude longitudinale du développement des enfants du Québec (ELDEQ). Les deux parents ont rapporté leur historique de comportements antisociaux lorsque l’enfant avait 5 mois, et les jeunes les ont rapportés à 15 et 17 ans. Les parents ont rapporté leurs pratiques parentales coercitives lorsque l’enfant était âgé de 5 à 50 mois. Nous avons testé deux modèles médiationnels, un pour chaque parent, en contrôlant pour le statut socioéconomique et le sexe de l’enfant. Les pratiques parentales coercitives du père sont médiatrices de la continuité entre ses comportements antisociaux et ceux de l’enfant (β = 0,02; IC 95% = 0,00; 0,03), alors que les pratiques parentales coercitives de la mère ne le sont pas (β = 0,01; IC 95% = -0,00; 0,02). Les résultats ne diffèrent pas selon le sexe de l’enfant. L’absence d’un lien indirect chez les mères indique que d’autres facteurs expliquent la continuité intergénérationnelle de ces comportements tandis que le faible lien indirect chez les pères identifie une cible d’intervention.
RELEVANSI PEMBELAJARAN BERDIFERENSIASI DENGAN PENDIDIKAN JIWA PERSPEKTIF IBNU SINA
Authors: Balqisa Ratu Nata  , Annisa Rahmania Azis  , Nazila Mumtaza Zamhariroh  , Mohammad Salik  , Muhammad Fahmi  
Published: January 2025

Artikel ini membahas relevansi antara konsep pembelajaran berdiferensiasi dengan konsep pendidikan jiwa perspektif Ibnu Sina. Ibnu Sina menegaskan pentingnya memperhatikan perkembangan jiwa, bakat, dan karakter unik setiap individu dalam proses pendidikan. Penelitian ini bertujuan untuk mengeksplorasi bagaimana teori pendidikan jiwa Ibnu Sina dapat memberikan landasan filosofis yang kuat bagi implementasi pembelajaran berdiferensiasi. Penelitian ini menggunakan metode kualitatif dan menggunakan studi pustaka sebagai pendekatan. Hasil penelitian menunjukkan bahwa konsep pendidikan jiwa Ibnu Sina sejalan dengan gagasan pembelajaran berdiferensiasi dalam kurikulum merdeka, di mana setiap peserta didik tidak dapat disamaratakan, tetapi disesuaikan dengan perkembangan fisik, jiwa, usia, intelektual, dan moral. Menurut Ibnu Sina, setiap manusia dipandang sebagai individu yang memiliki potensi yang unik dan berbeda. Oleh karena itu, pendidikan idealnya memperhatikan kebutuhan dan perkembangan jiwa seseorang secara khusus sesuai dengan perkembangan usia anak. Implikasi dari penelitian ini adalah agar pendidik menyesuaikan metode pembelajaran dengan kebutuhan emosional, intelektual, dan spiritual peserta didik, supaya menjadi lebih personal dan efektif.