bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spatial and temporal distribution of reported dengue cases and hot spot identification in Quezon City, Philippines, 2010–2017
Authors: Medina John Robert C. , Takeuchi Rie , Mercado Chris Erwin G. , de los Reyes Calvin S. , Cruz Rolando V. , Abrigo Melvin D. R. , Hernandez Paul Michael R. , Garcia Fernando B. , Salanguit Mika , Gregorio Ernesto R. , Kawamura Shin’ya , Hung Khew Ee , Kaneko Masami , Nonaka Daisuke , Maude Richard J. , Kobayashi Jun 
Published: May 2023

Abstract
Background
Dengue remains a major public health problem in the Philippines, particularly in urban areas of the National Capital Region. Thematic mapping using geographic information systems complemented by spatial analysis such as cluster analysis and hot spot detection can provide useful information to guide preventive measures and control strategies against dengue. Hence, this study was aimed to describe the spatiotemporal distribution of dengue incidence and identify dengue hot spots by barangay using reported cases from Quezon City, the Philippines from 2010 to 2017.

Methods
Reported dengue case data at barangay level from January 1, 2010 to December 31, 2017 were obtained from the Quezon City Epidemiology and Surveillance Unit. The annual incidence rate of dengue from 2010 to 2017, expressed as the total number of dengue cases per 10,000 population in each year, was calculated for each barangay. Thematic mapping, global cluster analysis, and hot spot analysis were performed using ArcGIS 10.3.1.

Results
The number of reported dengue cases and their spatial distribution varied highly between years. Local clusters were evident during the study period. Eighteen barangays were identified as hot spots.

Conclusions
Considering the spatial heterogeneity and instability of hot spots in Quezon City across years, efforts towards the containment of dengue can be made more targeted, and efficient with the application of hot spot analysis in routine surveillance. This may be useful not only for the control of dengue but also for other diseases, and for public health planning, monitoring, and evaluation.
Safety of Inpatient Zoledronic Acid in the Immediate Postfracture Setting
Authors: Fan WuQiang , Leder Benjamin Z , Mannstadt Michael , Ly Thuan V , Franco-Garcia Esteban , Bolster Marcy B 
Published: May 2023

Abstract

Context
Zoledronic acid (ZA) administered during the initial hospitalization for a fragility fracture improves the osteoporosis pharmacotherapy rate. Distinguishing the safety profile of inpatient ZA (IP-ZA) in this context is crucial if this approach is to be widely adopted.

Objective
To study the acute safety profile of IP-ZA.

Methods
An observational study of patients admitted to the Massachusetts General Hospital with fragility fractures who were eligible to receive IP-ZA. Patients were treated with or without IP-ZA. Acetaminophen, either as a single pre-ZA dose or standing multiple-doses-per-day regimen for 48 hours or longer after ZA infusion, was also administered along with protocolized vitamin D and calcium supplementation. Changes in body temperature, serum creatinine, and serum calcium were measured.

Results
A total of 285 consecutive patients, meeting inclusion and exclusion criteria, are included in this analysis; 204 patients received IP-ZA. IP-ZA treatment was associated with a transient mean rise of body temperature of 0.31 °C on the day following its administration. Temperatures above 38 °C were seen in 15% of patients in the IP-ZA group and 4% in the nontreated group. Standing multiple-doses-per-day but not a single pre-ZA dose of acetaminophen effectively prevented this temperature increase. IP-ZA did not affect serum creatinine levels. Mean levels of serum total calcium and albumin-corrected calcium decreased by 0.54 mg/dL and 0.40 mg/dL, respectively, at their nadirs (Day 5). No patient experienced symptomatic hypocalcemia.

Conclusion
IP-ZA along with standing multiple-doses-per-day acetaminophen, administered to patients in the immediate postfracture period, is not associated with significant acute adverse effects.
A Systematic Review on Long-Term Postsurgical Pain Outcomes; What Is the Effect of Upper Extremity Regional Anesthesia?
Authors: Droog Wouter , Walbeehm Erik T. , Konijn Julia B. , Lucas Benthe M. J. , Coert J. Henk , Stolker Robert Jan , Galvin Eilish M. 
Published: May 2023

BACKGROUND:
Chronic pain is a recognized complication of surgery, and it has been hypothesized that regional anesthesia might reduce the risk of development of chronic pain after upper extremity surgery.

METHODS:
A systematic literature review was performed to assess whether in patients undergoing elective upper extremity surgery (P), regional anesthesia (I), compared to general anesthesia (C), would result in lower long-term (>3 months) postoperative pain intensity (O). We included randomized and nonrandomized controlled trials (RCTs). Our primary outcome was numerical rating score or visual analogue scale for pain, at >3 months postoperatively. The Embase, Medline ALL, Web of Science Core Collections, Cochrane Central Register of Controlled Trials, and Google Scholar databases were searched for all reports assessing pain at >3 months after upper extremity surgery under general versus regional anesthesia. Secondary outcomes were: opioid prescription filling, complex regional pain syndrome (CRPS) incidence, the Mayo Wrist Score (MWS), and scores on the Disability of the Arm, Shoulder and Hand (DASH) questionnaire. Quality (or certainty) of evidence was evaluated using the Grading of Recommendations Assessment, Development and Evaluation (GRADE). Risk-of-bias was assessed using the Cochrane tool for randomized trials (RoB 2.0) and nonrandomized trials (ROBINS-I).

RESULTS:
This review included 14 studies, comprising 7 RCTs and 7 nonrandomized studies. Six of the 7 studies (4 RCTs, N = 273; 2 nonrandomized studies, N = 305) using a pain score, our primary outcome, report comparable long-term postoperative pain scores after regional and general anesthesia. Six of the 7 studies using our secondary outcomes report comparable long-term outcomes in terms of opioid prescription filling (2 retrospective cohort studies [RCSs], N = 89,256), CRPS incidence (1 RCT, N = 301), MWS (1 RCT and 1 RCS, N = 215), and DASH score (1 RCT, N = 36). Comparable outcomes were reported in all 7 RCTs (N = 778) and in 5 of the 7 nonrandomized studies, comprising 5 RCSs (N = 89,608). Two prospective observational studies (POSTs), comprising 279 patients, report a statistically significant difference in outcomes, with less pain and better DASH scores after brachial plexus anesthesia. All 14 studies provided moderate to very low certainty evidence, and there was a serious risk of bias due to confounding bias in 5 of the 7 nonrandomized studies (N = 631).

CONCLUSIONS:
The results of this review indicate that upper extremity regional anesthesia, compared to general anesthesia, is unlikely to change pain intensity at >3 months postoperatively.
“You'll Never Walk Alone”: School Crossing Guard Associations and Labor Feminism in the Postwar United States
Authors: Ryan Francis 
Published: May 2023

AbstractIn the years immediately following World War II, cities and townships across the United States implemented public safety programs to oversee road crossing for children outside schools. The crossing guards assigned to coordinate safe passage at busy intersections were primarily women and, as part-time workers, were a distinct sector of an expanding public sector workforce. This article highlights the origins of these public safety initiatives and how crossing guards formed associations in the 1950s and 1960s to secure economic improvements. These independent organizations articulated an important variant of labor feminism in the early postwar era, and attention to the agendas put forward by these women opens new insight into this aspect of working-class activism. Into the 1970s, many guard associations merged with AFL-CIO unions, especially the American Federation of State, County and Municipal Employees (AFSCME) and the Service Employees International Union (SEIU), becoming a catalyst for a range of programs that prioritized the needs of working women in collective bargaining agreements. The article concludes with an overview of the issues crossing guards and their organizations face in an age of increasing austerity in the new century.
A Novel and Simple Method Using Computed Tomography Streak Artifact to Determine the Orientation of Directional Deep Brain Stimulation Leads
Authors: Fayed Islam , Syed Mashaal , Gingold Eric , Alizadeh Mahdi , Sharan Ashwini , Wu Chengyuan 
Published: May 2023

BACKGROUND AND OBJECTIVES:
Directional leads have garnered widespread use in deep brain stimulation (DBS) because of the ability to steer current and maximize the therapeutic window. Accurate identification of lead orientation is critical to effective programming. Although directional markers are visible on 2-dimensional imaging, precise orientation may be difficult to interpret. Recent studies have suggested methods of determining lead orientation, but these involve advanced intraoperative imaging and/or complex computational algorithms. Our objective is to develop a precise and reliable method of determining orientation of directional leads using conventional imaging techniques and readily available software.

METHODS:
We examined postoperative thin-cut computed tomography (CT) scans and x-rays of patients who underwent DBS with directional leads from 3 vendors. Using commercially available stereotactic software, we localized the leads and planned new trajectories precisely overlaying the leads visualized on CT. We used trajectory view to locate the directional marker in a plane orthogonal to the lead and inspected the streak artifact. We then validated this method with a phantom CT model by acquiring thin-cut CT images orthogonal to 3 different leads in various orientations confirmed under direct visualization.

RESULTS:
The directional marker creates a unique streak artifact that reflects the orientation of the directional lead. There is a hyperdense symmetric streak artifact parallel to the axis of the directional marker and a symmetric hypodense dark band orthogonal to the marker. This is often sufficient to infer the direction of the marker. If not, it at least renders 2 opposite possibilities for the direction of the marker, which can then be easily reconciled by comparison with x-ray images.

CONCLUSION:
We propose a method to determine orientation of directional DBS leads in a precise manner on conventional imaging and readily available software. This method is reliable across DBS vendors, and it can simplify this process and aid in effective programming.
Emotional behavior and brain anatomy of the mdx52 mouse model of Duchenne muscular dystrophy
Authors: Saoudi Amel , Zarrouki Faouzi , Sebrié Catherine , Izabelle Charlotte , Goyenvalle Aurélie , Vaillend Cyrille 
Published: May 2023

ABSTRACT
The exon-52-deleted mdx52 mouse is a critical model of Duchenne muscular dystrophy (DMD), as it features a deletion in a hotspot region of the DMD gene, frequently mutated in patients. Deletion of exon 52 impedes expression of several brain dystrophins (Dp427, Dp260 and Dp140), thus providing a key model for studying the cognitive impairment associated with DMD and testing rescuing strategies. Here, using in vivo magnetic resonance imaging and neurohistology, we found no gross brain abnormalities in mdx52 mice, suggesting that the neural dysfunctions in this model are likely at the level of brain cellular functionalities. Then, we investigated emotional behavior and fear learning performance of mdx52 mice compared to mdx mice that only lack Dp427 to focus on behavioral phenotypes that could be used in future comparative preclinical studies. mdx52 mice displayed enhanced anxiety and a severe impairment in learning an amygdala-dependent Pavlovian association. These replicable behavioral outcome measures are reminiscent of the internalizing problems reported in a quarter of DMD patients, and will be useful for preclinical estimation of the efficacy of treatments targeting brain dysfunctions in DMD.
Proton Conduction through Water Chain in a Hydrogen-Bonded Molecular Crystal of Hexaimidazole Ruthenium(II) Complex and Dicarboxylate
Authors: Kobayashi Fumiya , Higuchi Suguru , Tadokoro Makoto 
Published: May 2023

Abstract
The development of molecular proton conductors has garnered considerable attention owing to their potential for use as solid-state electrolytes for fuel cells. Creating hydrogen-bonding networks between HIm (imidazole) and carboxylate is an attractive approach for constructing efficient proton conducting pathways. Herein, high proton conduction in a new hydrogen-bonded molecular crystal of [RuII(HIm)6](Glu)·4H2O (1·4H2O, H2Glu = glutaric acid) is demonstrated. 1·4H2O exhibited a proton conductivity of 1.33 × 10−4 S cm−1 at 318 K and 100% relative humidity. This is attributed to a three-dimensional (3D) hydrogen-bonding network via hydrogen-bonding between HIm and carboxylate group and water molecules, leading to produce a one-dimensional (1D) hydrogen-bonding water chain, which provides a proton conducting pathway. The calculated activation energy (Ea) value was 0.38 eV at 283–318 K, suggesting that proton transport in 1·4H2O is associated with the Grotthuss mechanism. The hydrogen-bonding networks between HIm and carboxylate may play a role to promote the proton hopping mechanism. This study will provide new molecular proton conductors using imidazole metal complexes.
Seeker head geometric parameters influence on the hypersonic aero-optical effect
Authors: Li Yubo , Deng Shuanghou , Zhou Zheng , Xue Caijun , Xiao Tianhang 
Published: May 2023

The aero-optical effect of hypersonic flight vehicles creates serious distortion on the imaging system. In this paper, based on the 2D model of a typical optical seeker, flow field density data are obtained by numerical simulation with different optical seeker head radii, cone angles, and relative positions of incident rays reaching the window as variables. Through a series of evaluation parameters, the aero-optical effect under different conditions is quantitatively computed by a ray tracing method. The results show that with the increase of the line of sight (LOS) angle, image deviation decreases. When the optical seeker radius is 40 mm and the cone angle is more than 20°, image deviation will not change with the increase of the cone angle. In the case of a small cone angle, the bore sight error (BSE) decreases gradually with the increase of LOS angle. The BSE decreases with the increase of the cone angle, and tends to be stable when the cone angle is above 40°. The variation of the optical path difference with respect to the flow field density is more sensitive than the distance from the shock wave region to the optical seeker window. The Strehl ratio decreases with the increase of the optical seeker cone angle, indicating that the larger the cone angle, the worse the imaging quality.
Online randomised trials with children: A scoping review
Authors: Lepage Simone , Conway Aislinn , Goodson Noah , Wicks Paul , Flight Laura , Devane Declan 
Published: May 2023

Background
Paediatric trials must contend with many challenges that adult trials face but often bring additional obstacles. Decentralised trials, where some or all trial methods occur away from a centralised location, are a promising strategy to help meet these challenges. This scoping review aims to (a) identify what methods and tools have been used to create and conduct entirely online-decentralised trials with children and (b) determine the gaps in the knowledge in this field. This review will describe the methods used in these trials to identify their facilitators and the gaps in the knowledge.

Methods
The methods were informed by guidance from the Joanna Briggs Institute and the PRISMA extension for scoping reviews. We systematically searched MEDLINE, CENTRAL, CINAHL, and Embase databases, trial registries, pre-print servers, and the internet. We included randomised and quasi-randomised trials conducted entirely online with participants under 18 published in English. A risk of bias assessment was completed for all included studies.

Results
Twenty-one trials met our inclusion criteria. The average age of participants was 14.6 years. Social media was the most common method of online recruitment. Most trials employed an external host website to store and protect their data. Duration of trials ranged from single-session interventions up to ten weeks. Fourteen trials compensated participants. Eight trials involved children in their trial design process; none reported compensation for this. Most trials had a low risk of bias in “random sequence generation”, “selective reporting”, and “other”. Most trials had a high risk of bias in “blinding participants and personnel”, “blinding of outcome assessment”, and “incomplete outcome data”. “Allocation concealment” was unclear in most studies.

Conclusions
There was a lack of transparent reporting of the recruitment, randomisation, and retention methods used in many of the trials included in this review. Patient and public involvement (PPI) was not common, and the compensation of PPI partners was not reported in any study. Consent methods and protection against fraudulent entries to trials were creative and thoroughly discussed by some trials and not addressed by others. More work and thorough reporting of how these trials are conducted is needed to increase their reproducibility and quality.

Ethics and dissemination
Ethical approval was not necessary since all data sources used are publicly available.
Socioeconomic and sex inequalities in chronic pain: A population-based cross-sectional study
Authors: Oliveira Ana Maria Braga de , Teixeira Doralice Severo da Cruz , Menezes Fabrício dos Santos , Marques Amélia Pasqual , Duarte Yeda Aparecida de Oliveira , Casarotto Raquel Aparecida 
Published: May 2023

Objective
We investigated the impact of socioeconomic inequalities on chronic pain of older adults according to sex.

Materials and methods
This population-based cross-sectional study used survey data from the 2015 cohort of the SABE Study (Saúde, Bem-estar e Envelhecimento), Brazil. Socioeconomic status was examined at individual level (educational attainment, financial independence, and race/skin color) and contextual level (Human Development Index). We analyzed the association between variables using the chi-square test and the Rao & Scott correction. Logistic regression models were adjusted for risk factors.

Results
The study comprised 1,207 older adults representing 1,365,514 residents 60≥ years of age in the city of São Paulo. Chronic pain was more frequent in females (27.2%) than in males (14.5%) (p<0.001). Females evidenced the worst self-perception of pain, especially those of the most vulnerable socioeconomic strata. Social inequalities impacted chronic pain in different ways between sexes. Among females, unfavorable living conditions (OR = 1.59; 95%CI 1.07; 2,37) and Blacks/Browns females were most likely to have chronic pain (OR = 1.32; 95%CI 1.01; 1.74). Among males, only the individual aspects were significant for the occurrence of chronic pain, such as low educational attainment (OR = 1.88; 95%CI 1.16; 3.04) and insufficient income (OR = 1.63; 95%CI 1.01; 2.62).

Discussion
The potential for inequality was greater for females than for males reflecting structural factors inherent in a highly unequal society. Conclusions: Equity-oriented health policies are critical to preventing pain in human aging.
Is Benin on track to reach universal household coverage of basic water, sanitation and hygiene services by 2030?
Authors: Gaffan Nicolas , Dégbey Cyriaque , Kpozèhouen Alphonse , Glèlè Ahanhanzo Yolaine , Johnson Roch Christian , Salamon Roch 
Published: May 2023

Introduction
With the end of the Millennium Agenda, the United Nations Member States adopted the Sustainable Development Agenda in 2015. This new agenda identifies 17 Sustainable Development Goals (SDGs) and 169 targets for 2030, including Water, Sanitation and Hygiene (WASH).

Objective
To study the evolution of household access to WASH services over the last two decades in Benin and make projections for 2030.

Methods
In this study, secondary analyses were performed using the datasets of the Demographic and Health Surveys in Benin from 2001 to 2017–2018. The statistical unit was the household. The achievement of the WASH SDGs targets was monitored through the proportion of households using individual basic WASH services, the proportion of households using surface water for drinking, and the proportion of households practising open defecation. The study generated Annual Percentage Changes (APCs) for outcome variables. Based on the APCs between 2001 and 2017–2018, projections were made for 2030.

Results
From 2001 to 2017–2018, household access to individual basic WASH services increased from 50.54% to 63.98% (APC = +1.44%), 5.39% to 13.29% (APC = +5.62%), and 2.12% to 10.11% (APC = +9.92%), respectively. At the same time, the prevalence of surface water consumption and open defecation among households decreased from 10.54% to 5.84% (APC = -3.52%) and 67.03% to 53.91% (APC = -1.31%), respectively. If the trend observed between 2001 and 2017–2018 remains unchanged, the national coverage of households with basic individual WASH services would be 76.50%, 26.33% and 10.51%, respectively, by 2030. The prevalence of surface water consumption and open defecation among households would be 3.73% and 45.71%, respectively, by 2030.

Conclusion
Benin achieved significant progress in household coverage of adequate WASH services over the last two decades. However, progress appears insufficient to achieve universal coverage of households with basic WASH services, and eliminate surface water consumption and open defecation by 2030. There is a need to strengthen research into the drivers of household access to adequate WASH services.