bluuebunny/crossref_metadata_2025_split huggingface dataset:
Increase of depression among children and adolescents after the onset of the COVID-19 pandemic in Europe: a systematic review and meta-analysis
Authors: Ludwig-Walz Helena , Dannheim Indra , Pfadenhauer Lisa M. , Fegert Jörg M. , Bujard Martin 
Published: December 2022

Abstract
Background
Research points to a high depression burden among youth during the COVID-19 pandemic; however, a lack of systematic evidence exists. We determine the change in depression symptoms among children and adolescents during COVID-19 compared to pre-pandemic baselines. By using country differences in pandemic-related restrictions and school closures in Europe as quasi-experimental design, we evaluate policy impacts on depression.

Methods
In this systematic review and meta-analysis, following the PRISMA statement, we searched six databases (MEDLINE, EMBASE, PsycINFO, Cochrane Central, Web of Science, WHO COVID-19) using a peer-reviewed search string up until March 18, 2022 with citation tracking and grey literature searches. No limitations regarding language and effect measures existed. We included studies that compared (1) general depression symptoms or (2) clinically relevant depression rates in children and adolescents (≤ 19 years) before and during the COVID-19 pandemic in Europe. The validated Oxford Stringency Index was used as indicator for pandemic-related restrictions. Screening for eligibility, extracting data from published reports and from unpublished data requested directly from study authors, assessing the study risk of bias and grading certainty of evidence using the GRADE approach, were all done in duplicate. Data were pooled in a random-effects model. PROSPERO: CRD42022303714.

Results
Of 7,422 nonduplicate records, 22 studies with data from 868,634 participants pre-pandemic and 807,480 during pandemic, met full inclusion criteria. For the comparison of depression symptoms before and during the COVID-19 pandemic, moderate certainty of evidence was observed for general depression symptoms (standardized mean difference, 0.21 [95%CI, 0.12–0.30]; I2 = 94%) and low certainty of evidence for clinically relevant depression rates (odds ratio, 1.36 [95%CI, 1.05–1.76]; I2 = 95%) for total population. Increase in general depression symptoms was higher for male adolescents, whereas increase in clinically relevant depression rates was higher for females. Effect estimates were significantly higher when pandemic-related restrictions were more stringent or school closure occurred.

Conclusion
An increase in depression symptoms occurred in a pre-pandemic vs. during-pandemic comparison within the COVID-19 pandemic, whereby pandemic-related restrictions (such as school closures) resulted in a considerable effect increase. Ensuring adequate supply of mental health recovery services and long-term monitoring is of high public health relevance.
Understanding youths’ concerns about climate change: a binational qualitative study of ecological burden and resilience
Authors: Thomas Isaiah , Martin Andrés , Wicker Antoine , Benoit Laelia 
Published: December 2022

AbstractBackgroundClimate change has been shown to have long-term effects on mental health, yet, to date, there have been few studies on how children and adolescents experience and respond to ecological changes and how and why they engage in climate action. We explored empirically young people’s views about climate change and how distinct cultural contexts influence individual climate action.MethodsWe invited children and adolescents (ages 7 to 18) and their caregivers from the general population in the United States and France to participate in semi-structured focus groups. We recruited 74 participants, 39 in the U.S. (33 children and adolescents, 6 parents) and 35 in France (32 children and adolescents, 3 parents). Focus groups with participants centered on their emotions, beliefs, and actions around climate change. We analyzed the focus group data and developed themes via grounded theory and symbolic interactionist approaches.ResultsMany participants described experiencing anger, hopelessness, guilt, and sadness in response to climate change, and a smaller number endorsed significant anxiety symptoms; many described frustration about needing to fix the mistakes of earlier generations. Younger participants frequently misunderstood the purpose of their parents’ eco-conscious behaviors unless they were provided with age-appropriate explanations. Participants described a spectrum of experiences when trying to discuss climate change with peers and family, ranging from genuine support to apathy to hostility. Between the two samples, U.S. participants experienced more conflict with adults about climate change than French participants, but French participants described a greater lack of political agency compared to U.S. participants. Participants in both samples expressed a relatively balanced view of climate action, recognizing the significance of individual actions while acknowledging the limits of their power in the face of systemic issues. Some found hope and empowerment through climate action and building communities around it.ConclusionDiscussing with children and adolescents what adults are doing to mitigate climate change can provide reassurance, model prosocial behaviors, and inspire their own investment in climate action. Adults seeking to support the psychological well-being of young people should both support their concerns and actions around climate change and create avenues for young people to meaningfully engage in climate action.
miRNome profiling of lung cancer metastases revealed a key role for miRNA-PD-L1 axis in the modulation of chemotherapy response
Authors: Cuttano Roberto , Colangelo Tommaso , Guarize Juliana , Dama Elisa , Cocomazzi Maria Pia , Mazzarelli Francesco , Melocchi Valentina , Palumbo Orazio , Marino Elena , Belloni Elena , Montani Francesca , Vecchi Manuela , Barberis Massimo , Graziano Paolo , Pasquier Andrea , Sanz-Ortega Julian , Montuenga Luis M. , Carbonelli Cristiano , Spaggiari Lorenzo , Bianchi Fabrizio 
Published: December 2022

AbstractLocally advanced non-small cell lung cancer (NSCLC) is frequent at diagnosis and requires multimodal treatment approaches. Neoadjuvant chemotherapy (NACT) followed by surgery is the treatment of choice for operable locally advanced NSCLC (Stage IIIA). However, the majority of patients are NACT-resistant and show persistent lymph nodal metastases (LNmets) and an adverse outcome. Therefore, the identification of mechanisms and biomarkers of NACT resistance is paramount for ameliorating the prognosis of patients with Stage IIIA NSCLC. Here, we investigated the miRNome and transcriptome of chemo-naïve LNmets collected from patients with Stage IIIA NSCLC (N = 64). We found that a microRNA signature accurately predicts NACT response. Mechanistically, we discovered a miR-455-5p/PD-L1 regulatory axis which drives chemotherapy resistance, hallmarks metastases with active IFN-γ response pathway (an inducer of PD-L1 expression), and impacts T cells viability and relative abundances in tumor microenvironment (TME). Our data provide new biomarkers to predict NACT response and add molecular insights relevant for improving the management of patients with locally advanced NSCLC.
Targeting G-quadruplex for rescuing impaired chondrogenesis in WRN-deficient stem cells
Authors: Leung Adrian On-Wah , Yiu Tsz-Ching , Liu Lingxiao , Tam Hei-Yin , Gu Shen , Tu Jiajie , Pei Duanqing , Cheung Hoi-Hung 
Published: December 2022

AbstractBackgroundPathogenic mutations inWRNare a cause of premature aging disease Werner syndrome (WS). Besides accelerated aging phenotypes and cancer predisposition, patients with WS also display underdevelopment in the skeletal system, characterized by short stature, light body weight and unusually thin extremities. The reasons for these developmental defects are not completely understood and the underlying molecular mechanism remains to be elucidated.ResultsIn this study, WRN was found to modulate transcription ofshort stature homeoboxgeneSHOX. Loss of WRN resulted in insufficient expression of SHOX, the gene dose of which is critical for driving chondrocyte differentiation. WRN could bind the G-quadruplex (G4) structures in theSHOXpromoter and stimulate transcription. Aberrant formation of G4 structures in WRN-deficient cells impeded normal transcription of SHOX, thus resulting in impaired chondrogenesis. Chondrogenesis could be rescued by overexpression of WRN helicase or SHOX, suggesting that SHOX is a downstream target of WRN. Gene editing of the G4 structures in theSHOXpromoter could increase SHOX expression, therefore rescuing the impaired chondrogenesis in WRN-deficient cells.ConclusionsOur data suggest that dysgenesis of the developing bone in WS might be caused by SHOX insufficiency. Aberrant formation of G4 structures inSHOXpromoter suppresses SHOX expression and impairs chondrogenesis. Targeted mutagenesis in the G4 structures enhances SHOX expression and thus providing an opportunity to rescue the chondrogenic defect.
Effects of using a snooze alarm on sleep inertia after morning awakening
Authors: Ogawa Keiko , Kaizuma-Ueyama Emi , Hayashi Mitsuo 
Published: December 2022

Abstract
Background
Many people use the snooze function of digital alarm clocks for morning awakening, but the effects of a snooze alarm on waking are unclear. We examined the effects of a snooze alarm on sleep inertia, which is a transitional state characterized by reduced arousal and impaired cognitive and behavioral performance immediately upon awakening.

Methods
In study 1, healthy Japanese university students responded to a sleep survey during a psychology class (study 1), and we collected 293 valid responses. In study 2, we compared a separate sample of university students (n = 10) for the effects of using or not using a snooze alarm on sleep inertia immediately after awakening from normal nocturnal sleep in a sleep laboratory.

Results
Of 293 valid respondents in study 1, 251 often used a tool to wake up in the morning (85.7%). Moreover, 70.5% reported often using the snooze function of their mobile phones, mainly to reduce anxiety about oversleeping. Study 2 indicated no differences in the sleep quality or quantity before awakening with or without the snooze alarm, except in the last 20 min. However, during the last 20 min of sleep with snooze alarm, the snooze alarm prolonged waking and stage N1 sleep. Stage N1 sleep is non-rapid eye movement sleep that is primarily defined as a drowsy state. Furthermore, Global Vigor values were enhanced after awakening compared to pre-sleep in the no-snooze condition.

Conclusions
Using a snooze alarm prolongs sleep inertia compared to a single alarm, possibly because snooze alarms induce repeated forced awakenings.
The impact of emotional leadership on Chinese subordinates’ work engagement: role of intrinsic motivation and traditionality
Authors: Wan Jin , Zhou Wenjun , Qin Mingyue , Zhou Haiming , Li Pingping 
Published: December 2022

Abstract
Background
Leaders’ emotions and emotion regulation strategies influence subordinates’ attitudes and behaviors, while previous studies have mostly taken an emotional perspective. Leaders’ emotional competence also has an impact on subordinates through motivational and cognitive pathways. Based on self-determination theory, this study examined the impact of emotional leadership on subordinates’ work engagement, as well as the mediating role of subordinates’ intrinsic motivation and the moderating role of traditionality.

Methods
We first performed a scenario experiment study in which 116 Chinese college students were asked to read experimental materials on different leadership behaviors and answer relevant questions. Subsequently, a questionnaire survey was conducted, in which 347 Chinese enterprise employees were asked to rate their own experiences with emotional leadership, work engagement and intrinsic motivation. We used SPSS 25.0 for performance reliability analysis, correlation analysis and hierarchical regression analysis to test the reliability of the scales and investigate the relationship between the variables. Bootstrap analysis was used to test the mediating and moderating effects.

Results
Emotional leadership has a significant direct positive effect on subordinates’ work engagement and positively influences subordinates’ work engagement through the mediation of subordinates’ intrinsic motivation. The effect of emotional leadership on intrinsic motivation is stronger for those with high traditionality than for those with low traditionality.

Conclusion
Emotional leadership can improve subordinates’ work engagement by stimulating their intrinsic motivation. Therefore, managers need to be able to effectively regulate and manage subordinates’ emotions to stimulate their intrinsic motivation and to differentiate the management of subordinates with different levels of traditionality to improve subordinates’ work engagement.
Feasibility and preliminary efficacy of training health workers in detecting Priority Mental Health Conditions among adolescents in rural South India
Authors: Siddaiah Archana , Srinivasan Krishnamachari , Satyanarayana Veena , Ekstrand Maria L. 
Published: December 2022

Abstract
Introduction
Half of all mental disorders start during adolescence, before 14 years. In India, the current prevalence of mental disorders in 13–17 years age group was 7.3%. Many gaps persist in the mental healthcare delivery through the national mental health program, the low psychiatrist population ratio being one of them. Community health workers can play an essential role in providing mental healthcare in such resource-constrained settings. The World Health Organization mental health gap action program (WHO mhGAP) is a widely studied mental health tool that health workers can use to identify mental disorders. The study’s aim was to test the preliminary efficacy of training healthcare workers (HCWs) in identifying mental health conditions among adolescents using modified WHO mhGAP modules.

Methods
The feasibility study was carried out in two Primary Health Centers (PHCs) in rural Bengaluru. Study had two components: (1) training of HCWs on adolescent mental health and (2) detection of selected priority mental health conditions among adolescents by trained HCWs. HCWs were trained in five adolescent mental health conditions using a training manual and modified WHO mhGAP modules that excluded emergency presentations and management sections. Pre- and post-training assessments were carried out. A sample of 272 adolescents attending PHCs were assessed for any mental health condition by HCWs using mhGAP modules. A sub-sample of adolescents and all adolescents identified by HCWs with a mental health condition was interviewed by the investigator to validate the diagnosis. Qualitative interviews were carried out with participating HCWs to understand the acceptability of the intervention, acceptability, and barriers to training in identifying mental health conditions among adolescents

Results
A total of 23 HCWs underwent training. There was a significant increase in the mental health knowledge scores of HCWs post-training compared to baseline (p value <0.001). Out of 272 adolescents, 18 (6.8%) were detected to have any mental health condition by HCWs as per the modified WHO mhGAP modules. A sample of 72 adolescents consisting of all adolescents identified with a mental health condition by HCWs and a random sample of adolescents without any diagnosis were validated by the research investigator (AS). There was a good agreement between diagnosis by health workers and the research investigator with a Cohen’s Kappa of 0.88. Four themes emerged from the qualitative analysis.

Conclusions
Training was effective in improving the knowledge of HCWs. There was a good agreement between trained HCWs and the investigator in detecting adolescent mental health conditions using modified mhGAP modules. The modified WHO mhGAP can thus be used by trained non-specialist HCWs to screen for adolescent mental health conditions in primary health centers.
Association of methylation status of ABCA1/G1 genes with the risk of coronary artery disease
Authors: Mansouri Elaheh , Esmaeili Fataneh , Montaseri Maryam , Emami Mohammad Amin , Koochakkhani Shabnaz , Khayatian Mahmood , Zarei Hasan , Turki Habibollah , Eftekhar Ebrahim 
Published: December 2022

Abstract
Background
ATP-binding cassette transporters A1/G1 (ABCA1/G1) is a main regulator of HDL (high-density lipoprotein) formation and reverse cholesterol transport. Impaired ABCA1/G1 genes function may seriously affect cholesterol homeostasis, leading to increased risk of cardiovascular disease. In the present study, the association of ABCA1/G1 genes methylation status with the risk of coronary artery disease (CAD), risk factors of CAD, and serum level of lipid parameters was investigated.
This study was conducted on 70 CAD patients and 40 control subjects. All CAD subjects with diabetes mellitus were excluded. The promoter methylation status of ABCA1/G1 genes was determined by the methylation-specific polymerase chain reaction (MS-PCR) method and serum lipid parameters were assessed using commercial kits.

Results
ABCA1 promoter methylation was higher in CAD group compared to the control participants (80% vs. 60%). Hypermethylation of the ABCA1 gene significantly increases the risk of CAD in the total population (OR 3.886, 95% CI (1.181–12.791), p = 0.026). ABCG1 methylation status showed no difference between CAD and control subjects. In addition, no significant association was noted between methylation status of ABCA1/G1 and serum level of lipid profile.

Conclusions
Altogether, our study shows that ABCA1 gene promoter hypermethylation may increase the risk of CAD, which may help identify people at risk of developing CAD.
Memória em chamas
Authors: Mazuquieri Reis Lucas Manuel 
Published: December 2022

Buscando compreender o impacto das práticas visuais na historicidade contemporânea, esse texto estuda algumas imagens produzidas no Brasil de 2021: as fotografias do incêndio da Cinemateca Brasileira, a obra de net-art Ditamapa, o incêndio da estátua de Borba Gato, a depredação do Escadão Marielle Franco e sua posterior restauração. Investigamos como os arquivos visuais destes eventos ajudam a pensar os embates entre as políticas de memória que dão forma à nossa condição histórica, considerando que as imagens não apenas representam a experiência vivida, mas são também agentes produtores de experiências no real.
AVALIAÇÃO DE BASES GALÊNICAS DESENVOLVIDAS EM UMA FARMÁCIA UNIVERSITÁRIA MAGISTRAL
Authors: Monteiro Mariana Sato de Souza Bustamante , Santos Elisabete Pereira dos , Freitas Zaida Maria Faria de , Nigro Fiammetta , Toma Helena Keiko , Britto Camila Alves 
Published: December 2022

As farmácias magistrais dispõem de bases galênicas para a produção de medicamentos tópicos. O creme não iônico e o creme Lanette® são exemplos de bases galênicas muito utilizadas, sendo necessária a sua padronização e o acompanhamento de parâmetros mínimos de qualidade, para garantir um produto estável e homogêneo. Esse trabalho teve como objetivo avaliar as características do creme não iônico e o creme Lanette®, por meio dos testes de viscosidade, densidade, pH, fator de oclusão, espalhabilidade, teste microbiológico, e realizar estudo de estabilidade por meio dos ensaios de pH, viscosidade, densidade e pureza microbiológica 30, 60 e 90 dias após preparo das formulações. O creme não iônico e creme Lanette® se apresentaram semissólidos, inodoros e de coloração branca. O pH das formulações ficaram entre 5,4 e 6,1, compatível com o pH da pele e dentro da faixa recomendada pela Anvisa. As formulações apresentaram densidade acima de 0,85 g/mL, o que é preconizado pela Anvisa. O creme não iônico apresentou um fator de oclusão (F) maior que 50%, favorecendo os efeitos de oclusão e hidratação na pele. Todas as formulações desenvolvidas apresentaram valor de viscosidade entre 1,00 - 1,85 x 103 cP, durante 90 dias após preparo das formulações, a 25 oC e 40 oC. O teste microbiológico mostrou que tanto o creme não iônico quanto o creme Lanette® contendo o conservante, não apresentou crescimento microbiológico por 90 dias após preparo das formulações. As bases galênicas podem ser consideradas estáveis do ponto de vista físico-químico e microbiológico e estão conforme os parâmetros indicados pela Farmacopeia Brasileira.
Targeting NMDA receptor signaling for therapeutic intervention in brain disorders
Authors: Chen He , Dong Yuanping , Wu Yun , Yi Feng 
Published: December 2022

Abstract

N-Methyl-d-aspartate (NMDA) receptor hyperfunction plays a key role in the pathological processes of depression and neurodegenerative diseases, whereas NMDA receptor hypofunction is implicated in schizophrenia. Considerable efforts have been made to target NMDA receptor function for the therapeutic intervention in those brain disorders. In this mini-review, we first discuss ion flux-dependent NMDA receptor signaling and ion flux-independent NMDA receptor signaling that result from structural rearrangement upon binding of endogenous agonists. Then, we review current strategies for exploring druggable targets of the NMDA receptor signaling and promising future directions, which are poised to result in new therapeutic agents for several brain disorders.
24 Jie Ling Gu (24 Festive Drums): Imagining the 24 Jie Ling (Phenomena) of China in Enacting Cultural Solidarity among the Chinese Diaspora of Malaysia
Authors: Chan Clare Suet Ching 
Published: December 2022

The 24 Jie Ling Gu (24 Festive Drums) is a drum ensemble that consists of 24 lion drums (shigu) played by twenty-four drummers who move to spectacular and dynamic choreography in synchronization with the rhythmic patterns struck on the shigu. It is an “invented tradition” created by the Chinese diaspora of Malaysia. In response to the 1970s National Cultural Policy (NCP) which aimed toward the construction of a homogenized national identity, the Chinese founded the 24 Jie Ling Gu ensemble to enact cultural solidarity and unify the people toward a sense of belonging to their distant motherland in China. They created the music and movements of the 24 Jie Ling Gu to manifest the 24 jie ling (phenomena)—the weather changes, agricultural activities, and natural phenomenon inherent in the 24 jie qi (jie: joints; qi: breath) or seasonal periods. Due to the fact that the Chinese of Malaysia have not physically experienced China but are connected to it through literature and media technology, I argue that the 24 Jie Ling Gu performers utilized their imagination and localized experience of Malaysia to manifest the 24 jie ling in China. This article is based on ethnographic fieldwork and ongoing revisits to this genre through a span of more than 20 years.