bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quasi-subjects in cyber law
Authors: Chubukova S. G. 
Published: May 2023

The system of subjects of cyber law is in the process of constant development due to the emergence of new digital technologies. An actual theoretical problem is the development of the theory of quasi-subjects in law and the definition of the legal status of an electronic person as a quasisubject of law.A quasi-subject is a person who does not possess all the characteristics of a subject of law. It is possible to distinguish such types of quasi-subject as persons: endowed with subjective rights and obligations, but not responsible (intellectual agents, cyberphysical systems, artificial intelligence systems, robots); not having legal personality, but realizing their interests through the interests of subjects of law, as a rule, as constitutional and legal imperative (future generations).
Optimization of hyperspectral systems of fluorescent testing of food products
Authors: Kasumov V.A. , Alieva K.J. 
Published: May 2023

Spectral analysis – based on the study of the emission spectra of various substances. Samples of the analyzed substance are “burned” under certain conditions, the substance evaporates and dissonates into atoms, which, when excited, give a spectrum. The light emitted in this case, passing through the glass prism of the spectroscope, is decomposed into its constituent parts (different light) and the experimenter observes a number of different lines (linear spectrum). The lines judge the presence of a particular element in the analyzed product.
The higher the intensity of the lines, the higher the concentration of the substance. With the help of spectrographs, it is possible to photograph the radiation and, by the degree of blackening of the lines on the photographic plate, determine the concentration of a substance. The method is highly sensitive; impurities of substances determine up to 0.0001% – decimal fractions of a percent. The method is used to determine the mineral composition of products of plant and animal origin.
Luminescence is the glow of atoms, ions, molecules, and more complex particles of matter, which occurs as a result of the transition of electrons in them upon returning from an excited state to a normal one. To transfer particles to an excited state, the definition of the amount of energy is summed up. Glow or part of the energy is released in the form of luminescence quanta. This method is used to determine vitamins, proteins, and fats in milk, to determine the freshness of meat and fish and various spoilage of vegetables, fruits, to detect preservatives, drugs, carcinogens, pesticides in food products.
When assessing the quality of food products, great importance is given to their consistency. There are rheological methods for assessing consistency – the primary assessment of food products. Rheology studies the structural and mechanical properties of materials (deformation). Rheological properties include viscosity, elasticity, elasticity, and strength.
Perhaps the emergence of new, more advanced methods that will become widespread, i.e., each consumer will have the opportunity to determine the quality of the product with the help of a mini device (such as a radioactive background meter, etc.) when buying.
Огляд методів захисту Web-застосунків від вразливостей типу CSRF (міжсайтова підробка запитів)
Authors: Олійник Я.О. , Мельниченко П.І. 
Published: May 2023

В статті представлено дослідження методів захисту Web-застосунків від вразливостей типу CSRF (міжсайтова підробка запитів). Проведене дослідження показало, що розробники Web-застосунків не приділяють достатньої уваги захисту від атак типу Міжсайтова підробка запитів, тому авторами було систематизовано та запропоновано комплекс методів захисту від CSRF-атак, та сформовано рекомендації для розробників Web-застосунків, для забезпечення комплексного захисту від CSRF-атак. Автори пропонують використовувати ряд методів, до яких відносяться: використання CSRF-токену у тілі запиту та у HTTP-заголовку, передача даних у альтернативному вигляді без використання MIME-типів класичних HTML-форм, перевірка заголовку Referer, використання атрибуту SameSite та підтвердження користувачем високочутливих операцій.
Запропоновані методи дозволять розробникам створювати безпечні Web-застосунки, які будуть невразливі до CSRF-атак.
Метод підвищення надійності вимірювань за допомогою координатно вимірювальної руки в режимі реального часу
Authors: Квасніков В.П. , Катаєв Д.А. , Квашук Д.М. 
Published: May 2023

У статті розглянуто поняття надійності вимірювання, де для кожної вимірної величини можна визначити інтервал форми та розташування поверхонь. Якщо міра отриманої величини потрапляє в цей інтервал, то вона вважається надійною. У статті також розглянуто імовірнісні ризики вимірювань, які пов'язані з наявністю джерел систематичних похибок вимірювання. Для розподілених систем, таких як КВР, рекомендується діагностичний підхід на основі резервування на основі математичних моделей. У статті також зазначено, що систематичні похибки ніколи не можуть бути повністю компенсовані. Розподілені системи досить вразливі, але можуть бути успішно захищені відповідними інструментами діагностики. Доведено що онлайн діагностика, представлена в статті, дозволяє контролювати надійність вимірювань КВР в режимі реального часу на основі деяких статистичних тестів та може бути застосовані до будь-якої розподіленої системи.
Posttraumatic Stress Disorder and Breastfeeding Migrant Mothers: A Scoping Review
Authors: Hirani Shela Akbar Ali , Lento Nicole 
Published: May 2023

Introduction:Breastfeeding is highly recommended to promote the physical and mental health of mothers and infants. Unfortunately, migrant mothers face many barriers to their breastfeeding practice and often suffer from posttraumatic stress disorder (PTSD) due to traumatic events during migration and their settlement in the host country. There is a lack of research on the interrelationship of breastfeeding, PTSD, and the migrant status of mothers. This review presents existing research in the field and provides recommendations to improve the breastfeeding practices of migrant women with PTSD.Methods:This scoping review was undertaken in consultation with the patient partners. After searching various databases, 116 articles were found. We reviewed and analyzed five articles that were relevant to migrant mothers, breastfeeding, and PTSD.Findings:Migrant mothers with PTSD face additional breastfeeding barriers in the host countries due to lack of support, pressure to assimilate, racial stigma, inequalities surrounding breastfeeding, lack of culturally sensitive care, language barrier, misinformation, the norm of formula feeding, and stress. Some recommendations include psychosocial interventions, creating private areas to breastfeed in public, reducing pressure for new mothers to return to work, training healthcare workers to be culturally competent, addressing societal stigma, educating migrant mothers on breastfeeding, and offering social support. Also, healthcare workers should take a warm approach, conduct safety assessments, educate themselves on PTSD, notice nonverbal cues, and employ multidisciplinary professionals and interpreters.Conclusions:While research shows that culturally competent healthcare workers, support, and education can aid with PTSD and breastfeeding, future research is needed surrounding the interconnectedness of PTSD, breastfeeding, and migrant mothers. Research on this unique population will allow for better support. Future research should employ patient partners in the development of novel interventions for breastfeeding migrant mothers with PTSD.
Physiology, pharmacology and prospects for dipeptidilpeptidase-4 inhibitors use
Authors: Kurkin D. V. , Bakulin D. A. , Morkovin E. I. , Strygin A. V. , Gorbunova Yu. V. , Volotova E. V. , Makarenko I. E. , Saparova V. B. , Drai R. V. , Petrov V. I. 
Published: May 2023

Modern requirements for the treatment of type 2 diabetes mellitus (DM2) include not only achieving a glycemic control, but also reducing the risk of developing cardiovascular complications. Dipeptidyl peptidase 4 (DPP-4) inhibitors are inferior in the effectiveness to some other actively developing groups of hypoglycemic drugs (SGLT2 inhibitors and GLP-1 receptor agonists); however, they seem relevant at the present time.The aim of the study is to analyze the literature data on the therapeutic potential and results of the of DPP-4 inhibitors research.Materials and methods. When searching for the review article materials, the abstracting databases of PubMed, Google Scholar and e-Library were used. The search was carried out on the publications for the period from 2006 to 2022, using the following keywords: DPP-4 inhibitors; glucagonlike peptide-1 (GLP-1); glucose-dependent insulinotropic peptide (GIP); sitagliptin, and other drugs.Results. DPP-4 belongs to the serine proteases family and is involved in the degradation of various chemokines and peptide hormones, including incretins secreted by intestinal L- and K-cells – GLP-1 and GIP. They regulate a postprandial insulin secretion and a β-cell function, modulate a fasting and postprandial glucagon secretion, regulate the eating behavior and have many pleiotropic (immunomodulatory, anti-inflammatory, antifibrotic, etc.) effects. DPP-4 inhibitors reduce an enzyme activity by 70–90%, increasing plasma incretin levels by 2–4 times and have been used to treat DM2 since 2006. Now there are 13 DPP-4 inhibitors on the market in different countries, differing primarily in pharmacokinetic parameters. They are actively used in the combination therapy for type 2 diabetes, increasing the glycemic control effectiveness without increasing the risk of hypoglycemia. The evidence is emerging about the therapeutic potential of DPP-4 inhibitors in COVID-19.Conclusion. A peroral form, an ability to create effective combinations with other hypoglycemic drugs without increasing the risk of hypoglycemia, the pleiotropic effects of DPP-4 inhibitors, make this group relevant at the present time.
Species Distribution Modelling Using Bioclimatic Variables on Endangered Endemic Species (Bubalus depressicornis and Bubalus quarlesi)
Authors: Aldiansyah Septianto , Wahid Khalil Abdul 
Published: May 2023

Sulawesi Island is an island located in the Wallacea area. Most of the fauna on the island of Sulawesi is a transitional fauna from Australia and Asia. This study aims to model the potential distribution of the species Bubalus depressicornis and Bubalus quarlesi using famous models in the present and in the future as a result of climate change phenomena throughout the island of Sulawesi and beyond their natural habitat. The parameters used are bioclimatic variables and in-situ presence data. The method used is Maximum Entropy by comparing the GLM, SVM, and RF algorithms. The model is evaluated with reference to the values of AUC, COR, TSS, Deviance, and observation data. The RF model is quite good in modeling the distribution of B. depressicornis and B. quarlesi species with AUC values of 0.92 and 1, COR values of 0.59 and 0.84, TSS values of 0.87 and 1, and Deviance values of 0.37 and 0.08, respectively, while the results of data observations show values of 80% and 84%. B. depressicornis was most affected by bio14=0.665, while B. quarlesi was most affected by bio2=0.525, which means that this endemic species is suitable to live in a tropical climate with a warm and wet climate throughout the year, where the difference in temperature at night and during the day is very large. In the future, B. depressicornis and B. quarlesi are estimated to be compatible in an area of 143,281.78 km2 (81%) and 136,892.89 km2 (77%) of the Sulawesi.
Keywords : Species Distribution Model; Bubalus depressicornis; Bubalus quarlesi; Bioclimatic; Climate Change

Copyright (c) 2023 Geosfera Indonesia and Department of Geography Education, University of Jember
This work is licensed under a Creative Commons Attribution-Share A like 4.0 International License
Emergency Response Demand and Supply: A GIS-Based Network Analysis for Fire Station’s Service Coverage Delineation in Kano Metropolis, Nigeria
Authors: Yunus Sulaiman , Falola Julius Afolabi , Jaro Ibrahim Musa 
Published: May 2023

Inadequate fire emergency response infrastructure and a lack of defined service coverage remain key barriers to timely fire disaster response. This study is applied research which employed geospatial techniques and aimed at examining fire disaster emergency response demand and supply relationships with the view to delineating service coverage and locating more facilities for optimum coverage in Kano metropolis. Locations of the existing fire stations and fire incidents (2009-2019) were gathered through GPS surveying. Network data set were generated. Nearest Neighbor and Network Analysis (origin-destination, service coverage and location-allocation) were conducted to determine emergency response demand and supply relationships, service coverage area delineation and identifying best site for allocating new facilities within the metropolis respectively. It was found that no clearly defined service coverage exist as emergency response supply takes more than 4-8 times the NFPA travel standard, and with a great deal of overlapping response patterns. New service coverage areas were proposed and best sites for 8 firefighting facilities identified for optimum coverage. It is concluded that emergency fire disaster response demand and supply relationships within Kano metropolis is imbalanced, with extensive recurrent demand especially within the core area served by overstretched and inefficient response supply. This, therefore, implies continuous exposure of lives and properties to the menace of fire disaster in Kano metropolis.
Keywords: Fire Facilities; Location-allocation; Response Demand; Response Supply; Service Coverage

Copyright (c) 2023 Geosfera Indonesia and Department of Geography Education, University of Jember
This work is licensed under a Creative Commons Attribution-Share A like 4.0 International License
Analysis of Potential Cinnamomum zeylanicum Blume Essential Oil Against Alzheimer’s Disease: A Molecular Docking Study
Authors: Shodiq Muhammad Ja'far , Hartono Farmindo , Khaerunnisa Siti , Machin Abdulloh 
Published: May 2023

Background: Alzheimer's Disease (AD) is a neurodegenerative disorder with progressive impairment of behavioural and cognitive functions and the most common cause of dementia. The pathophysiology of AD is associated with low acetylcholine, accumulation of amyloid beta plaque, and neurofibrillary tangles in the brain. Cinnamomum zeylanicum is known to have many medicinal properties, especially neuroprotective effects. Objective: This research was designed to determine the neuroprotective potential of the phytochemicals C. zeylanicum using an in silico study. Methods: There are 5 phytochemicals compounds of C. zeylanicum used in this study. It's qualified for Lipinski’s rules of five and can cross blood brain barrier. The protein targets were AChE, BACE1, and GSK-3. Molecular docking and visualization were performed using Avogadro, AutoDock 4.2 PyMol and Biovia Discovery Studio 2019. Results: In silico results show that the main phytochemical compounds of C. zeylanicum Blume essential oil have great potency as an AD drug. The best interaction model of the compound was shown by trans-cinnamyl acetate and coumaric acid. Although the binding energy of the compounds is lower than AD drugs (donepezil, rivastigmine, galantamine), the binding energy is not much different from rivastigmine and galantamine. Conclusion: The phytochemical compounds of C. zeylanicum Blume essential oil have an effect as a neuroprotective agent for AD and should be investigated in future research.
Dynamic and multivalent engagement determines context-dependent nucleosomal deacetylation by the Rpd3S complex
Authors: Li Haitao , Guan Haipeng , Wang Pei , Zhang Pei , Ruan Chun , Ou Yutian , Peng Bo , Zheng Xiangdong , Lei Jianlin , Li Bing , Yan Chuangye 
Published: May 2023

Abstract
Context-dependent dynamic histone modifications constitute a key epigenetic mechanism in gene regulation. The Rpd3S complex recognizes H3K36 trimethylation (H3K36me3) and deacetylates histones H3 and H4 at multiple sites across transcribed regions. Here we solved the cryo-EM structures of yeast Rpd3S in its free and H3K36me3-nucleosome bound states. We demonstrated a unique architecture of Rpd3S, in which two copies of Eaf3-Rco1 heterodimers are asymmetrically assembled with Rpd3 and Sin3 to form a catalytic core complex. Multivalent recognition of two H3K36me3 marks, nucleosomal and linker DNAs by Eaf3, Sin3 and Rco1 positions the catalytic center of Rpd3 next to the histone H4 N-terminal tail for deacetylation. In an alternative catalytic mode, combinatorial readout of unmethylated H3K4 and H3K36me3 by Rco1 and Eaf3 directs histone H3-specific deacetylation except for the registered H3K9ac. Collectively, our work illustrates dynamic and diverse modes of multivalent nucleosomal engagement and methylation-guided deacetylation by Rpd3S, highlighting the exquisite complexity of epigenetic regulation with delicately designed multi-subunit enzymatic machineries in transcription and beyond.
U-Pb constraints Late Miocene Hipparionine fauna stratigraphic age at 7.26 Ma
Authors: Zhang Pu , Li Fanyang , Zhu Guangyou , Edwards R. Lawrence 
Published: May 2023

AbstractThis paper presents the first application of U-Pb dating to resolve the geological age of the Late Miocene mammalian fauna. Five fossil beds containing late Miocene mammalian fauna can be found in northern China, which include fossil specimens ofHipparion chiai,is most fixed time indicator fossil. However, the geological age of the fossil belt is still unresolved. Absolute dating of sedimentary rocks and fossils from the late Miocene is still rare, mainly due to the difficulties arising from suitable absolute dating technique and sample diagenetic changes. Biological Apatite (carbonated Hydroxyapatite) in the teeth fossils ofHipparion chiaicontain Uranium, high μ value (the initial value of238U/204Pbi), limited Th content and remain relatively unchanged due to their resistance to diagenetic alterations. Here, we first derived six fossil teeth ofHipparion chiaiwere sampled from the Wangdafuliang section in Fugu, in the Shaanxi Province, and were dated using the U/Pb method to obtain an absolute age. The U-Pb dates obtained from the six fossil teeth ofHipparion chiaivaried, ranging from 6.87±0.13 Ma to 7.71±0.39 Ma (2 s), with an average of 7.26 Ma. This result provides a new basis for determining the age of theHipparion chiai-Dinocrocuta gigantean-Hezhengia-Shaanxispirastandard fossil belt (index fossil assemblage) from the Late Miocene in northern China. The belt is probably 7.26 Ma, rather than previous estimates of 10–9 Ma. The absolute dating of fossils, in turn, bring about a new revolution in Biostratigraphy and establish the geochronology of sedimentary sequences at sub-millennial timescales, especially those early Cenozoic stratigraphy that is absent of an suitable absolute dating technique.
JAK2 Genetic Variation Potentially Associated with Susceptibility to Severe A(H1N1) Influenza
Authors: Cheng Zhong-shan , Zhou Jie 
Published: May 2023

Abstract
Genetic variation in JAK2, a key player in cytokine signaling, may affect the severity of influenza. We sought to identify single nucleotide polymorphisms (SNPs) of JAK2 predisposing to severe A(H1N1) influenza. A pilot genome wide association study (GWAS) of A(H1N1) influenza harvested 15 highly linked SNPs of JAK2 that were differentially distributed in severe cases and mild controls. Four SNPs, including a promoter SNP rs1887429 and its high linkage disequilibrium (LD) SNP rs7034539 (R2 = 0.49 in Asian population), as well as other two high LD SNPs (rs17425819 and rs7850484; R2 = 0.88) associated with JAK2 expression in Chinese lymphoblastoid cell lines (n = 45), were evaluated in an extension cohort (n = 343). The four SNPs of JAK2 were significantly associated with the severe influenza in both combined analysis (n = 463) and meta-analysis (all p-values < 0.01). A potential functional enhancer harboring one SNP rs59384377 and an indel rs527982744 (-/19T-repeat) were identified to be in high LD to rs17425819 and rs7850484, and the enhancer was predicted to regulate the promoter activity of JAK2. Reporter gene luciferase assay demonstrated that rs59384377 and rs527982744 encoded regulatory polymorphisms for the enhancer activity. Furthermore, JAK2 expression was upregulated by A(H1N1) virus infection, and the inhibition of JAK2 by the inhibitor NVP-BSK805 attenuated the A(H1N1) virus-triggered induction of two important influenza immune response genes, IP-10 and IL-8. In conclusion, the genetic association study together with molecular and cellular experiments support JAK2 as a potential host factor in the pathogenesis of severe A(H1N1) influenza, but further replication of the association is warranted.
A new family of Polak-Ribière-Polyak conjugate gradient method for impulse noise removal
Authors: Mousavi Ali , Esmaeilpour Mansour , Sheikhahmadi Amir 
Published: May 2023

Abstract
In this paper, impulse noise removal problem is formulated as an unconstrained optimization problem with smooth objective function. It can be solved by conjugate gradient methods with desired properties (low memory and strong global convergence) in high dimensions. Accordingly, a family of the Polak-Ribi`ere-Polyak (PRP) conjugate gradient directions is constructed for which the descent condition holds. In other words, we introduce four improved versions of PRP method three of which are based on a regularization and one of which is the combination of Fletcher-Reeves and PRP conjugate gradient parameters. Using several images, it is shown that the new methods are very robust and efficient in comparison with other competitive methods for impulse noise removal, especially in terms of the peak signal to noise ratio (PSNR).
Mathematics Subject Classification (2000) 90C30a . 90C25 . 90C90 . 68U10 . 03D15
Electric Field Sensing of Etchless Lithium Niobate Heterostructure with Low Driving Voltage based on Quasibound States in the Continuum
Authors: Huang Zhijin , Wang Junzhong , Yuan Lifang , Shen Kaixiang , Li Qianqian , Wang Juan 
Published: May 2023

Abstract
Realizing lithium niobate-based electric field (E-field) sensor for low driving voltage has been attractive extensive attention in field of extremely weak electric field detection, wireless communications, and even astronomical observations. However, lithium niobate (LN) is difficult to be etched with high accuracy. Here, we theoretically proposed a heterostructure E-field sensor consisted of etchless LN thin film and metagratings to support Fabry-Perot-like BIC mode, which has not only ultrahigh quality (Q) factor but also large extinction ratio. Due to the loss of electrodes, the BIC mode transitions into quasi-BIC resonance with Q factor of 2050. This quasi-BIC resonance is utilized to confine electromagnetic field inside the LN layer leading to an optical field enhancement factor to 14.2 times normalized to unpatterned thin film LN. And this resonance also boosts the strong interaction among optical field, EO material and applied electric field. Numerical simulations are carried out to demonstrate the Fabry-Perot-like quasi-BIC resonance is sensitive to the refractive index change Δn of LN material. As a result, we construct the relationship between the Δn and the applied electric field and successfully obtained a tuning sensitivity of 40.8 nm/V and low driving voltage of 18.9 mV with wavelength resolution of 0.38 nm. Meanwhile, we estimate the 3dB bandwidth of the E-field sensor should exceed 154 GHz after considering the low parasitic capacitance of LN material and high conductivity of electrodes. And we believe that the LN-based heterostructure has potential applications in ultralow driving voltage E-field sensors.