bluuebunny/crossref_metadata_2025_split huggingface dataset:
Increase of solubility and transmembrane permeability of niclosamide from its mechanochemically synthesized solid dispersions
Authors: Meteleva Elizaveta S. , Roenko Elizaveta A. , Polyakov Nikolay E. 
Published: August 2023

More than 4.5 billion people worldwide are affected by parasitic diseases, with helminth infections accounting for 99% of the total number. Niclosamide (NS) is a weakly acidic active pharmaceutical ingredient (API) used to treat helminth infections. However, the pharmaceutical use of pure niclosamide is limited by its low bioavailability due to its poor aqueous solubility. The aim of this work is a mechanochemical preparation of niclosamide solid dispersions with increased solubility. Due to the pH dependence of NS water solubility and possible complexes formation, NS solid dispersions (SD) with 2-hydroxypropyl-β-cyclodextrin (HP-β-CD) and alkalizing agents, such as calcium carbonate (CaCO3) and N-methyl-D-glucamine (MG) are mechanochemically prepared in this study. The physical properties of NS SD in solid state are characterized by differential scanning calorimetry, X-ray diffraction, FT-IR spectroscopy, and scanning electron microscopy studies. The characteristics of the water solutions formed from the obtained SDs are analyzed by HPLC. It is shown that the solubility increases for all studied compositions. These phenomena are obliged by complexation with HP-β-CD, which was shown by 1H-NMR methods, and enhanced ionization in the cases of using calcium carbonate and MG. Results of the parallel artificial membrane permeability assay (PAMPA) have shown that mechanochemically obtained NS/MG SD (1/1 mass ratio, 8 h milling) significantly enhances permeation of NS across an artificial membrane. Thus, the obtained compositions are a promising basis for the development of NS-based preparations for oral administration, with reduced dose and high pharmacological effect.
El sedentarismo y su incidencia en el estado nutricional de los asistentes a la vía activa y saludable
Authors: Ortiz Sanguino Wilson , Contreras Eugenio Benito , Arévalo Portilla Juan Fernando , Ferrebus Silva Johan , Hernández Gamboa José Orlando 
Published: August 2023

El artículo es producto de una investigación que tuvo como objetivo: Valorar la incidencia del sedentarismo en el Estado Nutricional de los asistentes a la vía activa y saludable de Villa del Rosario, Departamento Norte de Santander. Metodología: El estudio cuantitativo identifica como variables: el tiempo sedentario de los individuos asistentes en el desempeño cotidiano, clasificación del estado nutricional derivado del Índice de Masa Corporal. Para la recolección de la información se tomaron las medidas antropométricas de los asistentes a la vía activa y saludable de Villa del Rosario Departamento Norte de Santander y se procedió a realizar un instrumento que contenía información sobre las posiciones sedentarias, el tiempo de descanso diario y la aplicación de la actividad física cotidiana de los participantes. Para el análisis de la información se asume el método estadístico con procesamiento para la interpretación de los resultados gráficos. En conclusión: al realizar la relación entre tiempo sedentario de los individuos asistentes a la vía activa y estado nutricional, se concluye que en los asistentes a la vía activa y saludable existe una incidencia negativa de la falta de ejercitación cotidiana de los individuos, así como la aplicación de actividades generalmente en posición sedente, elementos que conllevan a mantener un desequilibrio nutricional por el inadecuado desgaste energético, trayendo consigo estados de sobrepeso y obesidad en los asistentes.
Kadınların Cinselliğe Bakışının Online Seslifoto (OSF) ile İncelenmesi
Authors: ÖZKAN Nazlı , TANHAN Ahmet 
Published: August 2023

“Kadın” ve “Cinsellik” yan yana dahi getirilmekten kaçınılmış iki kavram. Konuşulmayan, öğretilmeyen ve keşfedilirken birçok toplumsal engelle karşılaşan cinsellik, bireyin varoluşunun yadsınamaz bir parçası. Bu sebeple birçok konuda öteki haline gelmiş kadınların cinselliğe bakışını görebilmek amacıyla bu araştırma yürütülmüştür. Araştırmanın önceliği, ele alınmayan bu konuyu bilimsel bir yöntemle inceleyerek bireyin farkındalık kazanmasına yardımcı olmaktır. Bir diğer amacı ise ortaya çıkan veriler aracılığıyla diğer bireylere ulaşarak konuyla ilgili toplumsal farkındalık oluşturmaktır.
Farklı eğitim düzeyine sahip kadınların cinselliğe bakışını incelerken Online Seslifoto (OSF) yöntemi kullanılmış ve katılımcılardan cinselliklerini tanımlayan temsili bir fotoğraf çekmeleri istenmiştir. Çektikleri bu fotoğrafa, GÖZSAN sorularından faydalanarak yazdıkları hikaye ile anlam katmışlardır. Son olarak ise, katılımcıların sözcüklerinin zarar görmemesi için “tema”nın onlar tarafından belirlendiği Online Yorumlayıcı Fenomenolojik Analiz (OYFA) yapılmış; bu temalar üzerinden tüm katılımcılar, araştırmacı tarafından belirlenen “ana tema” gruplarına dahil edilmiştir.
Çalışma sonunda 12 ana tema ortaya çıkmıştır. En sık tekrarlanan ana temalardan ilk üçü şöyle olmuştur: Hoşa giden/istenen duygular (aitlik duygusu, aşk, coşku, güven, heyecan, huzur, masumiyet/saflık, mutluluk, sevgi, şefkat, tutku, umut, zevk) ( n=56, % 32), hoşa giden/istenen bedensel hisler(ahenk/uyum, arzulamak, canlanma, cinsel uyarılma, dişil hissetmek, gevşeme/ enerji boşaltımı, güçlü hissetmek, hissetmek, orgazm, tanrıça gibi hissetmek) (n=28, %16), Hoşa giden/istenen davranışlar(dokunmak/temas, haz, ilgi, mastürbasyon, öpüşmek, saygı, seks, teslimiyet, yakınlık) (n=28, %16).
Katılımcıların cinsellik tanımlarına eğitim düzeyi boyutuyla bakılmış ve farklılık olup olmadığı araştırılmıştır. Eğitim düzeyinin cinselliği tanımlamada farklılaştığı yerin, “Özgürlük” ve “Varoluş- Kendini arama/tanıma/keşif” ana temaları olduğu görülmüştür. Bu temalar yalnızca lisans, yüksek lisans ve doktora eğitim düzeylerinden katılımcılar tarafından kullanılmıştır.
Pandemi döneminde yapılmış olan bu araştırma, Online Seslifoto (OSF) ve kadın cinselliğini ilk kez bir araya getirmesi sebebiyle alanyazına katkı sağlayacağı düşünülmektedir.
AN OVERVIEW OF STUDENT’S ANXIETY IN ASSALAFIYAH II MLANGI BOARDING SCHOOL YOGYAKARTA BASED ON AGE AND GENDER
Authors: Farhany Fajrul Falah , Rachmawati Meyka Budi , Ernia Winda , Rahmawati Natasya Putri Imam , Arifah Naily Zahrotun 
Published: August 2023

Introduction: Anxiety is a feeling of fear that is unclear and not supported by the situation. When anxious, the individual feels discomfort or fear with no identifiable object. Anxiety disorders are one of the most common psychological disorders in adolescent patients. Every individual is inseparable from anxiety. The anxiety can be mild, moderate, or severe. At school, students also experience anxiety for various reasons, such as anxiety about subjects, anxiety about failing in learning, and others.
Method: This quantitative descriptive study was conducted at the Assalafiyah II Mlangi Islamic Boarding School in July-September 2022. The target population in this study included 840 students using a total sampling technique. Data was collected online with Generalized Anxiety Disorder (GAD) questionnaires.
Result: The results showed significant differences in the level of anxiety based on aged in Assalafiyah II Mlangi Islamic Boarding School (p-value 0.026) and significant results at the level of anxiety based on gender (p-value 0.000).
Conclusion: Female students need more anxiety counseling than male students. Besides that, there was no relationship between age and anxiety. This study assists in developing a strategic plan to reduce anxiety among boarding school students by developing Counseling Guidance Teachers or Psychologists.
Keywords: Mental Health, Anxiety, Islamic Boarding School, Students.
Study of the Removal Efficiency of Chromium Ions using a Membrane by Electro Kinetic Technique from Sludge
Authors: Hadi Nabaa Shakir , Awadh Huda 
Published: August 2023

Abstract
Aims: In recent years, electro kinetic (EK) remediation has become more popular as a novel method for removing chromium contamination from soil. This approach, however, is ineffective since it uses both cationic and anionic forms of chromium. In this work, a membrane –based technique was employed to increase the efficiency of the electro kinetic removal of chromium.
Methods: Chromium removal from polluted sludge was studied in four bench-scale experiments, two of which used distilled water (EK-1, EK2 &amp; Membrane) and two of which used acetic acid as a catholyte (EK-3, EK4 &amp;Membrane).
Results: The pH, total chromium, and fractionation of chromium in the sludge were measured after remediation. In the EK-1, EK-2 &amp; Membrane and EK-3, EK-4 &amp; Membrane trials, the average removal efficiency of total chromium was 47.6%, 58.6%, and 74.4%, 79.6%, respectively.
Conclusion: In contrast to the electro kinetic remediation strategy, which left approximately 80% of the sludge neutral or alkaline after treatment, the use of the membrane created acidic soil conditions throughout the sludge. For example, the high field intensity used in the membrane tests may have helped to facilitate chromium desorption, dissolution and separation from the sludge, as well as enhance chromium mobility. The findings show that the membrane can improve the effectiveness of chromium removal from sludge when utilized in the EK remediation process.
Data Pesawat Udara Tanpa Awak Untuk Pendukung Analisis Dinamika Pesisir dan Erosi Pantai
Authors: Fatchurohman Hendy , Indrawati Like , Ningtiyas Iswanti Rahayu , Nadhira Nur Anisa , Meliyasari Sasvita Gevi 
Published: August 2023

Kawasan pesisir menjadi salah satu area yang paling rentan terhadap ancaman bencana akibat percepatan perubahan iklim. Salah satu ancaman yang hampir terjadi di seluruh Kawasan pesisir di dunia adalah erosi pantai. Kawasan Pesisir Kabupaten Bantul, DIY menjadi salah satu area yang terdampak cukup parah oleh erosi pantai. Penelitian ini bertujuan untuk (1) Mengetahui proses dinamika pesisir di Kawasan Pantai Pandansimo ; (2) Memetakan tingkat kecepatan abrasi di Pantai Pandansimo, dan (3) Mengetahui penyebab utama dari proses erosi pantai yang terjadi. Citra satelit resolusi tinggi Pleiades dengan resolusi spasial 50cm digunakan untuk mengetahui perubahan garis pantasi secara temporal. Selain itu, citra satelit yang diperoleh dari Google Earth juga digunakan untuk analisis dari tahun 2010-2021. Perubahan garis pantai dihitung menggunakan software DSAS. Data morfologi detail didapatkan dari hasil akuisisi foto udara menggunakan pesawat tanpa awak multirotor. Berdasarkan hasil analisi diketahui bahwa proses dinamika pesisir didominasi oleh proses erosi pantai. Tercatat nilai kemunduran garis pantai rerata sebesar 2.46 meter/tahun. Erosi pantai yang terjadi disebabkan oleh beberapa faktor hidrodinamik dan morfodinamik seperti peningkatan kejadian gelombang ekstrem, berkurangnya suplai sedimen fluvial, dan fenomena perubahan iklim.
Determination of Maximum Power to Be Produced by a Solid Oxide Fuel Cell
Authors: Andrade Samuel Tadeu de Paula , Huebner Rudolf , Matencio Tulio , Ferreira Ricardo Poley Martins , Júnior Esly Ferreira da Costa 
Published: August 2023

Abstract
Solid oxide fuel cells can generate electrical energy more efficiently and reduce pollutant emissions. They can be applied in many practical engineering cases, such as stationary generation, aircraft, and hybrid fast charging stations. This work uses heuristic and deterministic optimization algorithms coupled with thermodynamics lumped models to determine the main operation variables to achieve maximum power. We found, as expected, that higher pressures improve the power output of one cell. For one cell operating near atmospheric pressure, the output power was 78.56 W; for an operating condition near 5 atm, the output power was 99.21 W. Moreover, the heuristic and deterministic algorithms obtained similar results. The proposed model can be improved with chemical kinetics and the inclusion of cell dimensions to become more precise but offers a base method to estimate the main operating variables of an SOFC.
Enhancing Supply Chain Decision-Making in the Textile Industry: A Hybrid Interval-Valued Neutrosophic MCDM Approach
Authors: R Venugopal , Veeramani C. , S Muruganandan 
Published: August 2023

Abstract
The COVID-19 pandemic has had a significant impact on the garment sector in the Asia-Pacific region, leading to a decline in retail sales in export markets and affecting supply chain businesses and employees. The selection of sustainable suppliers has become a top priority for organizations in the clothing supply chain to ensure effectiveness and efficiency. Supplier selection in the apparel sector involves multiple quantitative and qualitative parameters. The use of Multi-criteria Decision Making (MCDM) models has been extensively studied in various business sectors, including supplier selection and investment assessment. This study aims to develop a decisionmaking tool to assist decision-makers in selecting the best supplier in the clothing sector within a neutrosophic environment with interval values. The Interval-Valued Neutrosophic Analytic Hierarchy Process (IVNAHP) and the Interval-Valued Neutrosophic Technique for Order Preference Similarity to Ideal Solution (IVNTOPSIS) approaches are employed in this research for supplier selection. Two questionnaires are designed and distributed to experts in textile companies. The first questionnaire is used to evaluate the weights of criteria based on IVNAHP, while the second questionnaire ranks the companies based on IVNTOPSIS. To demonstrate the applicability and effectiveness of the proposed MCDM model, a real-world case study is conducted.
Measurement of the Sustentaculum Tali Range and Biomechanical Screw Analysis Based on the ‘Trabeculae Continental Shelf’ Concept
Authors: Zhang Yong , Weng Qiuyan , Zhang Yan-ru , Chen Jianming , Yang Yunfeng 
Published: August 2023

Abstract
Background
The sustentaculum tali plays an important role in the surgical treatment of calcaneal fracture. However, there is a lack of relevant literature report on the true extent of the distance process. The introduction of the ‘Continental Shelf’ delineation concept allowed the sustentaculum tali range to be defined with reference to the trabecula topographic trend. Here, we investigated the biomechanical properties of two common sustentaculum tali screws after implantation by applying the finite element method (FEM).
Methods
Dicom imaging data of the calcaneus sustentaculum tali was obtained by computed tomography (CT)scanning techniques and a spatial three-dimensional (3D) coordinate system was established to measure the extent of the sustentaculum tali. The continuation range was identified according to the trend of the trabecula bone and then superimposed to form a new sustentaculum tali range. Next, by structural design and FEM, we performed biomechanical tests on the two type of sustentaculum tali screws: the ‘pressure type (transverse group)’ test for vertical fracture lines and the ‘tension type (oblique group) of the center’ test.
Results
Based on the concept of ‘Continental Shelf’ concept, the spatial extent of the sustentaculum tali was redefined. According to FEM calculations, the load bearing capacity of the transverse group was better than that of the oblique group by 15.15% when the screws were implanted in the peak area. Furthermore, the load bearing capacity of the oblique group was better than that of the transverse group by 14.13% and 5.59% when the screws were implanted in the lumbar and valley regions.
Conclusions
Based on the concept of ‘Continental Shelf’ concept, the range of the sustentaculum tali was expanded. The best mechanical properties of two different screws were implanted in the peak area. The load-bearing capacity gradually reduced when implanted in the lumbar and valley regions. However, the waist area and valley area can still meet the requirements for structural strength and stability, and also provide a good fixation effect.
Level of Evidence: Therapeutic Level III. See Instructions for Authors for a complete description of levels of evidence.
Efficacy and safety of ultrasound-guided pulsed radiofrequency therapy of stellate ganglion on refractory painful diabetic peripheral neuropathy
Authors: wang jiying , yang peng , zheng hongli , xu weisheng , xue wangsheng , kan yanpeng , qu shen , lin fuqing 
Published: August 2023

Abstract
Background: The best tool for management of pain associated with distal symmetric peripheral neuropathy(DSPN) is a matter of debate. The use of ultrasound-guided pulsed radiofrequency (PRF) therapy of stellate ganglion (SG) in patients with painful DSPN may decrease pain severity and the need for analgesics.
Methods: Patients: We enrolled 56 patients with T2DM and refractory painful DSPN in this study. Intervention: The patients received bilateral ultrasound-guided SG pulsed radiofrequency therapies once on both sides.
Measurement: The patients completed the visual analog scale (VAS), simplified McGill pain questionnaire (SF-MPQ), pain index, Toronto clinical score system (TCSS), sleep duration at night (SDN), pain disability index (PDI), Karnofsky performance status (KPS), depression screening scale (PHQ-9), and anxiety screening scale (GAD-7) to assess severity and quality of pain. After completing the procedures,the patient’s subjective sensations, including the degree of perceived pain relief, level of perceived
numbness relief, extent of perceived chills relief, and side effects were assessed. All patients underwent baseline evaluation after the last procedure at 1-week, 4-week, 12-week, and 24-week follow-up periods.
Results: The postoperative VAS were significantly lower than the preoperative VAS scores (P<0.001). The SF-MPQ score at 1, 4, 12, and 24 weeks postoperatively were significantly lower than the preoperative SF-MPQ score (P<0.001). The KPS after the procedures was significantly higher than the preoperative KPS (P<0.001); the postoperative PDI was significantly lower than the preoperative PDI (P<0.001). The postoperative SDN (P=0.005) was longer than the preoperative SDN. The postoperative PHQ-9 score was lower than the preoperative score PHQ-9 (P<0.05). The degree of perceived pain relief, chills relief, and numbness relief at 4, 12, and 24 weeks after the procedure were lower than that at 1 week after the procedures (P<0.001). The postoperative rates of administration of oral anticonvulsants and non-steroidal anti-inflammatory drugs were lower than those of preoperative period (P<0.001). The significant effective rates at 4, 12, and 24 weeks after procedure, were 67.86%, 42.86%, 21.43%, and 17.86%, respectively and the total effective rates were 89.29%,71.43%, 46.43%, and 32.14%, respectively, with a decreasing trend at all follow-up periods. No serious complication was observed.
Conclusion: Ultrasound-guided stellate ganglion PRF therapy can effectively relieve pain and improve the quality of life in patients with refractory painful DSPN.
International Review Board Number: ChiCTR2000035544
Clinical Trial registration Number: SHSY-IEC-4.1/21-48/01
Fatty links between multisystem proteinopathy and Small VCP-Interacting Protein.
Authors: Martin Dale , Ramzan Firyal , Abrar Fatima , Kumar Ashish , Liao Lucia , Campbell Zurie , Gray Rachel , Akanni Oluwadurotimi , Guyn Colm 
Published: August 2023

Abstract

Multisystem proteinopathy (MSP) is a rare dominantly-inherited disorder that includes a cluster of diseases, including frontotemporal dementia, inclusion body myopathy, and Paget’s disease of bone. MSP is caused by mutations in the gene encoding Valosin-Containing Protein (VCP). Patients with the same mutation, even within the same family, can present with a different combination of any or all of the above diseases, along with amyotrophic lateral sclerosis (ALS). The pleiotropic effects may be linked to the greater than 50 VCP cofactors that direct VCP’s many roles in the cell. Small VCP-Interacting Protein (SVIP) is a small protein that directs VCP to autophagosomes and lysosomes. We found that SVIP directs VCP localization to autophagosomes in an acylation-dependent manner. We demonstrate that SVIP is myristoylated at glycine 2 and palmitoylated at cysteines 4 and 7. Acylation of SVIP is required to mediate cell death in the presence of the MSP-associated VCP variant (R155H-VCP), whereas blocking SVIP myristoylation prevents cytotoxicity. Therefore, SVIP acylation may present a novel target in MSP.
Serum CST4 Combined with CEA, CA72-4, CA125, CA19-9 Improves the Diagnosis Value of Gastric cancer and Changes in pre-operation and post-operation
Authors: Sun Ling , Sun Yan , Zhao Luqing , Si Lixiang , Pan Xiaohua , Yang Xiao , Lu Jianwei 
Published: August 2023

Abstract
Objective:
This study aims to investigate the potential enhancement of diagnostic accuracy in gastric cancer through the combined detection of serum tumor markers (CST4, CEA, CA72-4, CA125, CA19-9). Additionally, we examine CST4 levels in both preoperative and postoperative gastric cancer patients to evaluate the correlation between CST4 levels and tumor burden.
Results:
In gastric cancer, the positive rates of CST4, CEA, CA72-4, CA125, and CA19-9 were notably higher (20.34%, 20.76%, 14.41%, 8.9%, 11.44%, respectively) compared to those in the control group (4.35%, 4.35%, 0%, 1.45%, 7.25%, respectively). The sensitivity of these markers were as follows: CST4 (0.20), CEA (0.21), CA72-4 (0.25), CA125 (0.09), and CA19-9 (0.11). Their respective specificities were 0.96, 0.96, 1.0, 0.99, and 0.93. When these five tumor markers were combined, the AUC area increased to 0.74, indicating that the combined use of these markers significantly improved diagnostic efficacy compared to individual tests. Furthermore, significant differences were observed in CST4 levels pre- and post-operation in gastric cancer patients with varying stages, tumor sizes, and lymph node metastases. Notably, a significant difference in CST4 levels was found before and after surgery in patients with poorly differentiated gastric cancer (P < 0.001), but no such difference was observed in well-differentiated gastric cancer (P = 0.438).
Conclusion:
CST4, CEA, CA72-4, CA125, and CA19-9 all hold significant value in the diagnosis of gastric cancer. Specifically, serum CST4 may serve as a suitable tumor marker for gastric cancer screening. The combined use of CST4, CEA, CA72-4, CA125, and CA19-9 can significantly enhance the diagnostic accuracy for gastric cancer. Importantly, postoperative CST4 levels in gastric cancer patients were significantly lower than preoperative levels, with the exception of patients with well-differentiated tumors.