bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of biodiesel ratio and nozzle diameter on combustion and emissions of a biodiesel–DME-fueled engine
Authors: Hou Junxing , Xi Shuanghui , Wang Zhenghe , Li Shuhao 
Published: May 2023

This paper compares the combustion behavior and emission of a turbocharged compression ignition engine fueled with biodiesel BD100, dimethyl ether DME100, low-proportioned biodiesel blends BD30, and medium-proportioned biodiesel blends BD50. The impacts of biodiesel ratio and nozzle diameter on combustion and emissions characteristics were determined. The findings show that BD100 with a nozzle 6 × 0.24 mm has the highest value of maximum pressure, maximum pressure rise rate, maximum heat release rate, and NOx emissions. DME100 with a nozzle of 6 × 0.40 mm has the lowest values. CO emissions and HC emissions of BD100 with a nozzle 6 × 0.24 mm and DME100 with nozzles 6 × 0.40 mm and 6 × 0.35 mm gradually decrease. Among biodiesel blends, BD30 and BD50 with two types of nozzles, BD30 with a nozzle 6 × 0.40 mm has the lowest value of maximum pressure, maximum pressure rise rate, NOx emissions, and soot emissions. Compared with BD50, BD30 with nozzles 6 × 0.35 mm and 6 × 0.40 mm has lower CO emissions, HC emissions, and smoke emissions.
Single-Cell Profiling of CD8+ T Cells in Acute Myeloid Leukemia Reveals a Continuous Spectrum of Differentiation and Clonal Hyperexpansion
Authors: Desai Poonam N. , Wang Bofei , Fonseca Andre , Borges Pamella , Jelloul Fatima Zahra , Reville Patrick K. , Lee Eric , Ly Christopher , Basi Akshay , Root Jessica , Baran Natalia , Post Sean M. , Deng Qing , Sun Hanxiao , Harmanci Arif O. , Burks Jared K. , Gomez Javier A. , DiNardo Courtney D. , Daver Naval G. , Alatrash Gheath , Konopleva Marina , Green Michael R. , Antunes Dinler A. , Futreal Andrew , Hao Dapeng , Abbas Hussein A. 
Published: May 2023

Abstract
Comprehensive investigation of CD8+ T cells in acute myeloid leukemia (AML) is essential for developing immunotherapeutic strategies beyond immune checkpoint blockade. Herein, we performed single-cell RNA profiling of CD8+ T cells from 3 healthy bone marrow donors and 23 newly diagnosed (NewlyDx) and 8 relapsed/refractory (RelRef) patients with AML. Cells coexpressing canonical exhaustion markers formed a cluster constituting &lt;1% of all CD8+ T cells. We identified two effector CD8+ T-cell subsets characterized by distinct cytokine and metabolic profiles that were differentially enriched in NewlyDx and RelRef patients. We refined a 25-gene CD8-derived signature correlating with therapy resistance, including genes associated with activation, chemoresistance, and terminal differentiation. Pseudotemporal trajectory analysis supported enrichment of a terminally differentiated state in CD8+ T cells with high CD8-derived signature expression at relapse or refractory disease. Higher expression of the 25-gene CD8 AML signature correlated with poorer outcomes in previously untreated patients with AML, suggesting that the bona fide state of CD8+ T cells and their degree of differentiation are clinically relevant. Immune clonotype tracking revealed more phenotypic transitions in CD8 clonotypes in NewlyDx than in RelRef patients. Furthermore, CD8+ T cells from RelRef patients had a higher degree of clonal hyperexpansion associated with terminal differentiation and higher CD8-derived signature expression. Clonotype-derived antigen prediction revealed that most previously unreported clonotypes were patient-specific, suggesting significant heterogeneity in AML immunogenicity. Thus, immunologic reconstitution in AML is likely to be most successful at earlier disease stages when CD8+ T cells are less differentiated and have greater capacity for clonotype transitions.
A Novel Class of Ribosome Modulating Agents Exploits Cancer Ribosome Heterogeneity to Selectively Target the CMS2 Subtype of Colorectal Cancer
Authors: Terzo Esteban , Apte Shruti A. , Padhye Simran , Rashed Saleh , Austin Wesley , Caponegro Michael , Reddy Anupama , Shi Shuhao , Wang Christy , Clark Roger B. , Sidransky David , Modur Vijay , Badarinarayana Vasudeo 
Published: May 2023

Ribosomes in cancer cells accumulate numerous patient-specific structural and functional modifications that facilitate tumor progression by modifying protein translation. We have taken a unique synthetic chemistry approach to generate novel macrolides, Ribosome modulating agents (RMA), that are proposed to act distal to catalytic sites and exploit cancer ribosome heterogeneity. The RMA ZKN-157 shows two levels of selectivity: (i) selective translation inhibition of a subset of proteins enriched for components of the ribosome and protein translation machinery that are upregulated by MYC; and (ii) selective inhibition of proliferation of a subset of colorectal cancer cell lines. Mechanistically, the selective ribosome targeting in sensitive cells triggered cell-cycle arrest and apoptosis. Consequently, in colorectal cancer, sensitivity to ZKN-157 in cell lines and patient-derived organoids was restricted to the consensus molecular subtype 2 (CMS2) subtype that is distinguished by high MYC and WNT pathway activity. ZKN-157 showed efficacy as single agent and, the potency and efficacy of ZKN-157 synergized with clinically approved DNA-intercalating agents which have previously been shown to inhibit ribogenesis as well. ZKN-157 thus represents a new class of ribosome modulators that display cancer selectivity through specific ribosome inhibition in the CMS2 subtype of colorectal cancer potentially targeting MYC-driven addiction to high protein translation.

Significance:
This study demonstrates that ribosome heterogeneity in cancer can be exploited to develop selective ribogenesis inhibitors. The colorectal cancer CMS2 subtype, with a high unmet need for therapeutics, shows vulnerability to our novel selective ribosome modulator. The mechanism suggests that other cancer subtypes with high MYC activation could also be targeted.
Metabolomic Profiles Associated With Blood Pressure Reduction in Response to the DASH and DASH-Sodium Dietary Interventions
Authors: Kim Hyunju , Appel Lawrence J. , Lichtenstein Alice H. , Wong Kari E. , Chatterjee Nilanjan , Rhee Eugene P. , Rebholz Casey M. 
Published: May 2023

Background:
The DASH (Dietary Approaches to Stop Hypertension) diets reduced blood pressure (BP) in the DASH and DASH-Sodium trials, but the underlying mechanisms are unclear. We identified metabolites associated with systolic BP or diastolic BP (DBP) changes induced by dietary interventions (DASH versus control arms) in 2 randomized controlled feeding studies—the DASH and DASH-Sodium trials.

Methods:
Metabolomic profiling was conducted in serum and urine samples collected at the end of diet interventions: DASH (n=219) and DASH-Sodium (n=395). Using multivariable linear regression models, associations were examined between metabolites and change in systolic BP and DBP. Tested for interactions between diet interventions and metabolites were the following comparisons: (1) DASH versus control diets in the DASH trial (serum), (2) DASH high-sodium versus control high-sodium diets in the DASH-Sodium trial (urine), and (3) DASH low-sodium versus control high-sodium diets in the DASH-Sodium trial (urine).

Results:

Sixty-five significant interactions were identified (DASH trial [serum], 12; DASH high sodium [urine], 35; DASH low sodium [urine], 18) between metabolites and systolic BP or DBP. In the DASH trial, serum tryptophan betaine was associated with reductions in DBP in participants consuming the DASH diets but not control diets (
P
interaction, 0.023). In the DASH-Sodium trial, urine levels of N-methylglutamate and proline derivatives (eg, stachydrine, 3-hydroxystachydrine, N-methylproline, and N-methylhydroxyproline) were associated with reductions in systolic BP or DBP in participants consuming the DASH diets but not control diets (
P
interaction, <0.05 for all tests).

Conclusions:
We identified metabolites that were associated with BP lowering in response to dietary interventions.

Registration:

URL:
https://www.clinicaltrials.gov/ct2/show/NCT03403166
; Unique identifier: NCT03403166 (DASH trial). URL:
https://www.clinicaltrials.gov/ct2/show/NCT00000608
; Unique identifier: NCT00000608 (DASH-Sodium trial).
Research on the Impact of Data Production Factors on China’s Green Transition
Authors: Wang Yali , Yan Erwang 
Published: May 2023

Abstract
Since the 21st century, the digital economy has developed by leaps and bounds. As a key factor of production in the digital economy era, data plays an important role in China’s green transformation. Based on the panel data of 282 prefecture-level cities in China from 2011 to 2019, this paper studies the relationship between data elements and green transformation. The results show that data elements can significantly promote green transformation by improving technical efficiency and achieving technological progress. Based on the above conclusions, all regions should speed up the infrastructure construction of digital economy, train digital talents, reduce resource dependence, improve the green, low-carbon and circular development system, formulate a digital economy development strategy considering local economic development levels, improve resource utilization efficiency and labor productivity, and actively promote green transformation.
Impact of Pandemic Outbreak and Targeted Required Reserve Ratio Cut Policy on Stock Return Rate: Evidence from China
Authors: Wang Tian , Fang Fang , Zheng Linhao 
Published: May 2023

Abstract
This study analyzed the impact of COVID-19 outbreak and targeted required reserve ratio cut policy on stock returns of Chinese listed companies. This paper uses the data of 3,449 A-share listed companies from February 3, 2020 to December 31, 2020 for research, the empirical results showed that stock prices of private enterprises with stronger debt-paying ability and looser financing constraints, and state-owned enterprises with less supply chain credit risks performed better, in the central and western regions, enterprises with stronger solvency and looser financing constraints have better stock price performance during the early stages of pandemic. After the implementation of the targeted RRR cut policy, the stock prices of enterprises with poor solvency, private enterprises, and enterprises in central and western regions with strong financing constraints, state-owned enterprises, and enterprises in eastern region with high credit risks all showed significant reversals, and the stock prices reflected the effect of the targeted RRR cut policy in the short and medium term. Over time, the pandemic has been controlled, and the resumption of work and production has freed most enterprises from financial difficulties. However, due to sporadic outbreaks, large private enterprises and eastern enterprises with strong risk resistance and loose financing constraints enjoy better stock price performance. This study is helpful for enterprises to understand the value of financial flexibility and solvency and provides a reference for enterprises to make financial decisions: how to balance the benefits and costs of solvency.
La notation musicale dans le papyrus P. CtYBR inv. 4510 : relecture et nouvelles interprétations
Authors: Capron Laurent 
Published: May 2023

Abstract
After a new reading of P.CtYBR inv. 4510, combined with a musical analysis, it is possible to detect the presence of three musical pieces, written respectively in diatonic scales of hypo-iastian, iastian and hyper-iastian. These three melodies are notably different in their composition. The first one shows a large variety of rhythmical figures, uses chromatic degrees and metaboles, when the two others seem to be written in a soberer way. In particular, the hypothesis of a new scale, created by the componer for this first piece only, is proposed here.
Audio–Visual Cross-Modal Correspondences of Perceived Urgency: Examination through a Speeded Discrimination Task
Authors: Naka Kiichi , Yamauchi Katsuya 
Published: May 2023

Abstract
When presenting information in vehicle cockpits, it is essential to convey an appropriate urgency to the drivers. Perceived urgency has been investigated over the years for each modality, particularly audition and vision. However, the interaction between the modalities of perceived urgency has rarely been examined. To expand the insight into the design application of information presentation, we investigated the audio–visual interaction of perceived urgency using a priming task that involved speeded visual-target discrimination. A total of 60 auditory stimuli were created using a synthesizer. In addition, 13 color squares were used as visual stimuli. Three auditory stimuli with high, medium, and low perceived urgency, and two visual stimuli with high and low perceived urgency were selected based on a subjective evaluation test using a seven-point scale. A priming task was conducted to examine the cross-modal interaction of perceived urgency. Auditory stimuli were presented as prime stimuli, and the participants were asked to discriminate the visual target as quickly as possible. The results revealed that auditory stimuli with high and low perceived urgency facilitated responses to each visual stimulus with similar perceived urgency relative to each visual stimulus with different perceived urgency. The auditory stimulus with medium perceived urgency also facilitated responses to the visual stimulus with high perceived urgency relative to low. The present study shows that cross-modal correspondences can be observed when the stimuli are selected based on their subjective perceived urgency.
Constructing a Saint’s Life between Rome and the Provinces: Jesuit Hagiographical Literature on Peter Canisius
Authors: Friedrich Markus 
Published: May 2023

Abstract
There is general agreement about the Jesuits’ alertness to media, their crucial role in early modern printing, and their engagement in promoting the sanctity of some of their members through print publication. Despite several efforts to establish central control, most of the Society’s media production remained decentralized. Moreover, there was no pre-conceived publication strategy of hagiographical activities. As a result, the production of hagiographies often sprung up locally and with little initial awareness of each other. Hence, it was nearly unavoidable that projects overlapped and that competition between them arose. Examining two early hagiographic accounts of the life of Peter Canisius, the article sheds light on the Jesuits’ production and publication of hagiographical literature by linking the publication history of both projects to an investigation of the underlying manuscripts. As the paper demonstrates, early modern Jesuit print and manuscript culture cannot be separated.
Jesuits and Astrology: Print versus Manuscript
Authors: Campos Ribeiro Luís 
Published: May 2023

Abstract
Astrology played an important part in early modern European culture, as a fundamental part of both mathematical and astronomical traditions. During the same period, the Society of Jesus built their global educational enterprise, which included a proven expertise in mathematical and astronomical study. Although insufficiently acknowledged in Jesuit historiography, astrology formed an important part of this scientific project. Several Jesuit authors engaged in the study, teaching, and practice of astrology. From the mathematics curriculum of the Roman College to the Jesuit astrology classes in Portugal and Spain, the present article discusses astrology’s presence in early modern Jesuit publications. It examines the discussion of astrology in the Society’s scientific works, highlights the sharp contrast between the printed word and the manuscript tradition, and demonstrates how the latter provides a better guide to the role of astrology as part of Jesuit science.
Comparison of Postoperative Outcomes, Costs, and Readmission Between Total and Subtotal Cholecystectomy
Authors: Chervu Nikhil L. , Vadlakonda Amulya , Ascandar Nameer , Kronen Elsa , Bakhtiyar Syed Shahyan , Cho Nam Yong , Benharash Peyman 
Published: May 2023

Background An increasing body of literature supports subtotal cholecystectomy (STC) in the management of patients with difficult gallbladder anatomy; however, large-scale studies examining outcomes of total cholecystectomy and STC are lacking. Methods All adults undergoing total cholecystectomy or STC were tabulated from the 2016-2019 Nationwide Readmissions Database. Entropy balancing was performed to adjust for patient differences based on extent of resection. Subsequent multivariable regression models were used to assess the association of STC with major adverse events, postoperative length of stay (pLOS), hospitalization costs, and 30-day non-elective readmission rates. Results Of an estimated 854 357 patients, 7089 (.8%) underwent STC. Compared to total, STC patients were significantly older, less commonly female, and had a higher Elixhauser Index (all P < .001). Both cohorts had similar rates of postoperative ERCP (1.7% vs 1.5%, P = .33); however, the STC cohort had significantly higher utilization of subsequent drainage procedures (1.8% vs .5%, P < .001). After entropy balancing and multivariable risk-adjustment, STC was not associated with greater odds of MAE (AOR 1.11, 95% CI .99-1.23, P = .06). Notably, relative to total, STC was associated with longer pLOS ( β .14, 95% CI .11-.17, P < .001) and greater hospitalization costs (β + $1,900, 95% CI 1300-2,500, P < .001). However, the extent of resection was not associated with the likelihood of 30-day non-elective readmission (AOR 1.01, 95% CI .91-1.13, P = .86). Discussion Our findings suggest that STC is a viable, yet resource intensive, option in the management of complex cholecystitis.
Carotid Artery Perivascular Adipose Tissue Density and Response to Intravenous Tissue Plasminogen Activator in Acute Ischemic Stroke
Authors: Gencer Elif Sarionder , Yilmaz Ezgi , Arsava Ethem Murat , Gocmen Rahsan , Topcuoglu Mehmet Akif 
Published: May 2023

The importance of Carotid Artery Perivascular Adipose Tissue Density (CAPATd), a parameter that can be readily evaluated on emergency computed tomographic angiography (CTA), in acute stroke has not been adequately clarified. We created exploratory logistic regression models to detect the interaction between the effect of CAPATd and intravenous (IV) tissue plasminogen activator (tPA) in 174 patients (mean age 71 ± 14 years, 94 women) with acute ischemic stroke treated with IV-tPA alone. The CAPATd-average mean (−60.6 ± 18.7 vs −89.8 ± 25.3 Hounsfield units (HU), P = .002) and CAPATd-maximum (14.8 ± 68.9 vs −20.5 ± 39.8 HU, P = .020) values were higher on the ipsilateral side of carotid artery stenosis >60%. CAPATd-maximum ipsilateral emerged as an independent predictor for both modified Rankin’s Score 0–2 (52%) [exp(β) = .984] and mRS 0–1 outcome (32%) [exp(β) = .828] in addition to admission National Institutes of Health Stroke Scale, age and carotid plaque burden. CAPATd-maximum ipsilateral was acceptably accurate (Area under the Receiver operating characteristic Curve was .607, P = .0109 for mRS 0–2 and .613, P = .0102 for mRS 0–1). Ipsilateral CAPATd ≥ −25 HU predicted both mRS >3 and mRS >2 with usable sensitivity (59.8% and 66.07%) and specificity (63.6% and 59.68%). In conclusion, higher maximum CAPATd measured on emergency CTA indicates poorer functional prognosis in acute stroke patients treated with IV-tPA.
Extraction and characterization of a novel tropical fibre Megaphrynium macrostachyum as a biosourced reinforcement for gypsum-based biocomposites
Authors: Betené Achille D Omgba , Batoum Claude S , Ndoumou Belinga Remy L , Betené Ebanda Fabien , Tamba Jean G , Atangana Atéba , Moukené Roger , Tcheudjo Gilbert K , Nyembè André 
Published: May 2023

Identifying the potential of new bast fibres is a solution for diversifying biobased reinforcements and replacing environmentally harmful synthetic fibres. In this study, fibres were extracted from Megaphrynium macrostachyum stems by biological and chemical retting. The chemical fibres were bleached with a 2.5wt% sodium hypochlorite (NaClO) solution. The biological, chemical and bleached fibres were analysed from a chemical, morphological, physical, mechanical and thermal point of view. The possibility of using these fibres as reinforcement in gypsum-based biocomposites for construction was analysed by three-point bending tests. Chemical analysis revealed a cellulose content of more than 56 wt% within the usual range (50-85 wt%) for reinforcing fibres. SEM images showed that bleaching cleans the surface of the fibres. Physical analysis by gravimetric analysis showed that the bleached fibre had the lowest density (1.01 g.cm−3), fineness (5.2tex) and water absorption (64wt%). In addition, the highest thermal stability (237°C) was obtained for the chemical fibre. Young’s modulus and tensile strength, evaluated according to ASTM D3822-07, were dispersed and depended on the fibre diameter, and the highest values were obtained for the chemical fibre (6.4 GPa and 251 MPa). In contrast, gypsum composites with a volume fraction of 1.5% bleached chemical fibre had the highest stiffness (258 MPa) and flexural strength (5 MPa). The results obtained for each fibre type are relatively close to those of other fibres in the literature, indicating that all three fibre types studied can be used as alternative raw materials for the manufacture of gypsum-based biocomposites.
Socioeconomic inequalities of Long COVID: a retrospective population-based cohort study in the United Kingdom
Authors: Shabnam Sharmin , Razieh Cameron , Dambha-Miller Hajira , Yates Tom , Gillies Clare , Chudasama Yogini V , Pareek Manish , Banerjee Amitava , Kawachi Ichiro , Lacey Ben , Morris Eva JA , White Martin , Zaccardi Francesco , Khunti Kamlesh , Islam Nazrul 
Published: May 2023

Objectives To estimate the risk of Long COVID by socioeconomic deprivation and to further examine the inequality by sex and occupation. Design We conducted a retrospective population-based cohort study using data from the ONS COVID-19 Infection Survey between 26 April 2020 and 31 January 2022. This is the largest nationally representative survey of COVID-19 in the UK with longitudinal data on occupation, COVID-19 exposure and Long COVID. Setting Community-based survey in the UK. Participants A total of 201,799 participants aged 16 to 64 years and with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Main outcome measures The risk of Long COVID at least 4 weeks after SARS-CoV-2 infection by index of multiple deprivation (IMD) and the modifying effects of socioeconomic deprivation by sex and occupation. Results Nearly 10% ( n = 19,315) of participants reported having Long COVID. Multivariable logistic regression models, adjusted for a range of variables (demographic, co-morbidity and time), showed that participants in the most deprived decile had a higher risk of Long COVID (11.4% vs. 8.2%; adjusted odds ratio (aOR): 1.46; 95% confidence interval (CI): 1.34, 1.59) compared to the least deprived decile. Significantly higher inequalities (most vs. least deprived decile) in Long COVID existed in healthcare and patient-facing roles (aOR: 1.76; 95% CI: 1.27, 2.44), in the education sector (aOR: 1.68; 95% CI: 1.31, 2.16) and in women (aOR: 1.56; 95% CI: 1.40, 1.73) than men (aOR: 1.32; 95% CI: 1.15, 1.51). Conclusions This study provides insights into the heterogeneous degree of inequality in Long COVID by deprivation, sex and occupation. These findings will help inform public health policies and interventions in incorporating a social justice and health inequality lens.