bluuebunny/crossref_metadata_2025_split huggingface dataset:
Asexuality in Drosophila juvenile males is organizational and independent of juvenile hormone
Authors: Ji Xiaoxiao , Li Xiaolong , Wang Lin , Liu Suning , Jiang Xinyu , Pan Yufeng 
Published: August 2023

AbstractSexuality is generally prevented in newborns and arises with organizational rewiring of neural circuitry and optimization of fitness for reproduction competition. Recent studies reported that sex circuitry in Drosophila melanogaster is developed in juvenile males but functionally inhibited by juvenile hormone (JH). Here, we find that the fly sex circuitry, mainly expressing the male‐specific fruitless (fruM) and/or doublesex (dsx), is organizationally undeveloped and functionally inoperative in juvenile males. Artificially activating all fruM neurons induces substantial courtship in solitary adult males but not in juvenile males. Synaptic transmissions between major courtship regulators and all dsx neurons are strong in adult males but either weak or undetectable in juvenile males. We further find that JH does not inhibit male courtship in juvenile males but instead promotes courtship robustness in adult males. Our results indicate that the transition to sexuality from juvenile to adult flies requires organizational rewiring of neural circuitry.
The Effect of Strabismus Surgery on Refractive Error and Anterior Segment Measurement
Authors: TÜRKCAN SOĞUKSULU Tuğçe , TÜRK Adem , ÖZER Ömer 
Published: August 2023

Aim: This study aimed to investigate the effects of horizontal strabismus surgery on refractive error and anterior segment parameters.
Material and Methods: Fifty-four eyes of 27 patients were included in this study. Patients underwent repeated refraction measurements and anterior segment evaluation preoperatively, first week, first month, third month, and sixth month postoperatively. Patients were divided into three groups, those who underwent resection (group 1), recession (group 2), and healthy eyes without any surgical intervention (group 3).
Results: The mean age of the patients was 24.4±11.1 years and 14 (51.9%) were female. There was a statistically significant difference in central corneal thickness in group 2 before and after surgery (p=0.037). The mean central corneal thickness was highest in the first week with 548.14±40.42 µm and lowest in the first month with 541.50±41.75 µm after surgery. There was a statistically significant difference in cell density (p=0.004) and mean cell area (p=0.004) between groups 1 and 2 in the first week after surgery. The cell density level was statistically significantly higher in group 1 in all postoperative measurements. In addition, the mean cell area level was statistically significantly lower in group 1.
Conclusion: Strabismus surgery has an effect on anterior segment parameters in addition to correcting eye movements and visual axis. Depending on the type of intervention, the number of affected anterior segment parameters also varies. In the management of the patient in the postoperative period, the anterior segment structures should be carefully evaluated at each examination and the findings should be noted.
Effect of Hydroxytyrosol on Prdx6 Expression in Diabetic Rat Liver
Authors: ALMALI Eda Nur , KARACOR Kayihan , SOYLU Hakan 
Published: August 2023

Aim: Oxidative stress caused by hyperglycemia, which is the most important complication of diabetes mellitus, causes liver damage. Hydroxytyrosol is a polyphenolic compound abundant in olive oil that protects the liver against oxidative damage. Peroxiredoxin 6 (Prdx6) is an anti-oxidative enzyme known to exist in the liver. The aim of this study was to investigate the effect of hydroxytyrosol on Prdx6 expression in diabetes-induced liver injury.
Material and Methods: Male Wistar rats were grouped into four as the control group (n=10), hydroxytyrosol group (n=10), streptozotocin group (n=10), and hydroxytyrosol+streptozotocin group (n=10). Blood glucose levels of the animals were measured after streptozotocin injection and at the end of the experiment. The general structure of the liver was examined with a hematoxylin-eosin stain. Prdx6 protein expression was determined with an immunohistochemical method.
Results: In the streptozotocin+hydroxytyrosol group, blood glucose level was found to be lower when compared with the streptozotocin group (p
Implementation of Health Education Counseling on Breast Self Examination (BSE) with Android Media on Breast Cancer Prevention Behavior in Balikpapan
Authors: Hazanah Sri , Nilam Noorma  
Published: August 2023

Background: Breast cancer is a frightening disease for women. The prevalence of breast cancer in Indonesia is 109 per 100,000 population. The most cancer in EastKalimantan in 2014 was breast cancer with 179 people and in 2015 it rose to 424 people, this case experienced an increase of 56.28%. Aims: The aim of the researchers was to implement breast self-examination health education counseling (BSE) with Android media on breast cancer prevention behavior in Balikpapan. Method: This research method is a quasi-experimental study with a one-group pre-test and post-test design. The sample in this study was 2 groups of cadres totaling 50 people, each 25 people in the control group and 25 in the intervention group with ages 18-55 years. Results: The results of the study showed an increase in knowledge (good 48%, enough 40%, less 12%) and increased behavior about BSE (good 44%, enough 48%, less 8%), there was a difference in knowledge before and after being given BSE counseling using android media (p-value = 0.362). There are differences in behavior before and after being given the BSE counseling treatment using Android media (p-value = 0.607). Conclusion: Providing counseling using Android media provides better benefits.
Monitoring of three-phase distribution power transformer based on the Internet of Things (IoT) and SCADA
Authors: Badruzzaman Yusnan , Razaqi Revi Alvin 
Published: August 2023

The three-phase distribution transfomer, equipment for stepping down the voltage from medium (20/11,5 kV) to low voltage network (400/231 V) with a constant power, is a type of the PT. PLN (Persero) assets which has a direct relationship with customers. The condition and the performance of transformer are affecting on how the continuity of the electricity distributed. Hence, the monitoring process of three-phase distribution transfomer condition and performance should be done. Some elements which have to be monitored such as voltage (ZMPT101B sensor), current (ACS712 30 A sensor), power, and transfomer load. Those elements could be included as an electrical indicator.And then the transfomer’s temperature (DS18B20 sensor) and the oil transfomer level (HC SR04 sensor) could be included as a mechanical indicator. All of the sensors are processed and programmed with Arduino Mega 2560 which has been connected directly into an additional modul called Ethernet shield and router. The results then emitted by WiFi into SCADA to be shown. The results shown by SCADA is the information whether transformer need to be maintened or not
TAPHONOMIC INDICATORS OF DEAD OCEAN QUAHOG (ARCTICA ISLANDICA) SHELL AGE IN THE DEATH ASSEMBLAGE OF THE MID-ATLANTIC BIGHT CONTINENTAL SHELF
Authors: LECLAIRE ALYSSA M. , POWELL ERIC N. , MANN ROGER , REDMOND THERESA 
Published: August 2023

ABSTRACT
Taphonomic indicators are often used to assess time-since-death of skeletal remains. These indicators frequently have limited accuracy, resulting in the reliance of other methodologies to age remains. Arctica islandica, commonly known as the ocean quahog, is a relatively widespread bivalve in the North Atlantic, with an extended lifespan that often exceeds two hundred years; hence, their shells are often studied to evaluate climate change over time. This report evaluates taphonomic age using 117 A. islandica shells collected from the Mid-Atlantic Bight offshore of the Delmarva Peninsula with radiocarbon dates extending from 60–4,400 cal years BP. These shells had varying degrees of taphonomic alteration produced by discoloration and degradation of periostracum. To determine if a relationship exists between taphonomic condition and time-since-death, radiocarbon ages were compared with the amount of remaining periostracum and type of discoloration. Old shells (individuals that died long ago) were discolored orange with no periostracum while younger shells (individuals that died more recently) had their original color, with some periostracum. Both the disappearance of periostracum and appearance of discoloration followed a logistic process, with 50% of shells devoid of periostracum and 50% discolored in about 1,000 years. The logistic form of long-term taphonomic processes degrading shell condition is first reported here, as are the longest time series for taphonomic processes in death assemblages within the Holocene record. This relationship can be utilized for triage when deciding what shells to age from time-averaged assemblages, permitting more efficient application of expensive methods of aging such as radiocarbon dating.
Demystifying Hydrocarbon Potential of an Exploratory Well X-1 Marred by Challenging Hole Conditions Thru Smart Integration of Advanced Formation Testing and Cement Evaluation Logs
Authors: Siddique Faisal Anwar , Aslam Adeel , Khan Imran , Abbasi Yasir , Khan Mohammad Rasheed , Bari Abdul , Zubair Talha , Tanveer Muhammad Sohaib 
Published: August 2023

Abstract
In 2021, PPL spudded well X-1 targeting Basal Sands in 12.25" hole section, Massive Deep and Sembar Sands in 8.5" hole section. The well faced multitude challenges including borehole stability issues while drilling both reservoir sections. Nevertheless, despite the poor hole conditions, wireline formation testing was able to provide important information about the tight nature of the shallow formation penetrated by the well in 12.25" section. Consequently, reservoirs across the deeper 8.5" section were vital to the evaluation of this well. Accordingly, this paper sheds light on the deployment of an effective formation testing strategy, complemented by advanced, flexural attenuation-based cased hole cement evaluation logs.
Deteriorating hole conditions excluded the option of open hole reservoir testing, hence cased hole formation testing with Dual Packer was planned to achieve formation evaluation objectives in a comprehensive manner. Furthermore, routinely used ultrasonic pulse-echo based cement evaluation technique was upgraded to advanced flexural waves (Solid Liquid Gas mapping) methodology to gain confidence pertaining isolation between reservoir zones to be tested. Perforation intervals for testing were optimized based on cement evaluation results that led to efficient execution of the cased hole formation testing job. In addition, Interval-Pressure-Transient-Testing (IPTT) was performed to determine reservoir characteristics including permeability, skin, average pressure among others. Finally, well deliverability analysis was performed using steady-state wellbore simulator.
The implemented formation testing plan ultimately proved hydrocarbon presence across Massive Deep Sands, while Sembar was evaluated as depicting tight/dry behavior. Point forward, using IPTT analysis, elaborate characterization of Massive Deep Sands was performed, yielding parameters for tuning reservoir model and estimate reservoir deliverability. Moreover, formation testing results were also in-line with the DST outcome. Integrative findings from formation testing job yielded concrete conclusion with respect to the well’s potential by providing downhole gas samples for analysis, zone wise reservoir pressure, permeability, and skin, ultimately leading to reservoir deliverability estimations.
Data-Driven Facies Prediction Using Surface Drilling Parameters and Formation Elastic Properties – A Machine Learning Approach
Authors: Hussain Sadam 
Published: August 2023

Abstract
Unconventional reservoirs comprise of various heterogeneous productive and non-productive units which can be correlated with facies. To focus a target zone during drilling, it is essential to understand and identify unique zones in real-time. However, real-time LWD/MWD tools provide formation properties data with depth and time delay. Machine learning (ML) can help in predicting productive/non-productive facies/rock types without any time and depth delay enabling early decisions resulting in optimization of rig time and cost. In this study, ML approach has been employed to predict the frackable facies in a horizontal well in an unconventional reservoir using real-time surface drilling parameters and formation stress properties.
Initially, the whole data was pre-processed by visualizing through matrix scatterplots and histograms and outliers were removed. Optimum number of clusters were estimated using sum of squares within (SSW) and Silhouttee techniques. MinMax scaling methodology was used to scale up the elastic properties before clustering/labelling. Drilling data was also scaled in the supervised learning before predicting the labels. In the unsupervised learning, the data was labelled through K-means Clustering with 3 number of clusters. The supervised learning techniques used were 1) K-Nearest Neighbors (KNNs) classifier; 2) Support Vector Machine (SVM) classifier; and 3) Random Forest (RF) classifier. 80% of drilling data was used to train the classifier, whereas 20% of the data used to test the ML classifier. The hyperparameter grid optimization with 10 cross fold validations was also performed to optimize the parameters of all the classifiers. The variable importance was also evaluated through RF classifier to analyze the impact of sensitive drilling parameters on the predicted facies. Furthermore, confusion matrix and accuracy score of the best parameters also obtained and compared.
This study showed that KNNs, SVM, and RF classifiers predicted frackable facies with 78%, 78.5% and 76.6% accuracy respectively on 20% test data set. These results are based on hyperparameter grid optimization. Also, facie (2) was found to have the highest brittleness index where facie (3) was found to have the highest ductility. The accuracy of KNNs, SVM and RF classifiers based on confusion matrix was 79%, 74% and 77% respectively. The KNNs classifier outperformed both SVM and RF based on testing data. Additionally, it was observed that gamma radiation at bit and standpipe pressure were the most critical parameters in relating to confusion matrix accuracy and had variable importance of ~30% each. The supervised learning algorithms predicted lithology with over 75% accuracy, showing the robustness of data-driven modeling approach.
The success of ML based modeling approach can improve real-time decision making. This data-driven predictive model can also be extended to other wells in conventional rock formations.
Adding Life to Gas Wells Through Deliquification
Authors: Khan Z. H. , Iqbal F. , Ahmed R. 
Published: August 2023

Abstract
This work highlights the successful application of Gas Wells Deliquification techniques in UEP wells for improving recoveries and optimizing production from wells. Liquid loading is one the major challenge that gas well possess at the end of its life cycle. Gas well load-up is a major production challenge that can result in loss of recovery if not addressed cautiously. Most of the production comes from gas wells that are depleted and subject to liquid loading that leads to pre-mature wells load-up when the gas velocity in the tubing/casing is less than critical velocity.
In the continuous effort of production optimization and abandonment pressure reduction for improving recoveries, Gas Wells Deliquification as a project was introduced which included short term and long-term approach of mitigating liquid loading along with competency development. An integrated multi-disciplinary approach was taken to identify candidate wells and phased wise approach of implementing new technologies of soap sticks deployment, plunger lift and coiled tubing gas lift installation. Technology availability is considered as one of the main challenges in the application of these techniques.
The results are very positive in bringing back the production from load-up and shut-in wells. Some of the wells have revived back on production and added ~5-8 BCF reserves. During initial assessment of 300+ wells, ~50 wells are potential deliq candidates that can add potentially ~15-17 BCF of reserves with NPV of 7-10 MM$ in next 2-3 years.
New Similarity and Entropy Measures of Temporal Complex Neutrosophic Set and Its application in Multi-Criteria Decision Making
Authors: Lan Luong Thi Hong , Thong Nguyen Tho , Giang Nguyen Long , Smarandache Florentin , Nam Vo Si , Dzung Dinh Van 
Published: August 2023

Abstract
The Temporal complex neutrosophic set (TCNS) is an effective structure for dealing with information that has uncertain, indeterminate, and time-related factors in decision-making problems. In the last decade, many researchers focused on measuring the uncertainty and vagueness in knowledge using the properties of neutrosophic sets or extensions of neutrosophic sets. Information measures such as similarity and entropy measures are valuable tools for solving real-world multi-criteria decision-making (MCDM) problems. However, the existing method did not care or interest in the information measures of TCNS. This paper proposes several new similarity and entropy measures under the TCNS environment. The proposed measures have been verified and proven to comply with the axiomatic definition of the similarity and entropy measure for the TCNS. Finally, a numerical example related to choosing a tourist destination in Vietnam is given to demonstrate the practical applicability of the proposed measures. The numerical example proves that the proposed similarity and entropy measures of TCNS can produce accurate and reasonable results for decision-making problems in the real world.
Reflexology in oncological treatment – a systematic review
Authors: Klaus Moritz , Kutschan Sabine , Maennle Heidrun , Hübner Jutta , Dörfler Jennifer 
Published: August 2023

Abstract
Background:
As cancer and its therapy comes with a wide range of negative effects, people look for options to mitigate these effects. Reflexology is among the options of complementary medicine.
Method:
In March 2022 a systematic search was conducted searching five electronic databases (Embase, Cochrane, PsychInfo, CINAHL and Medline) to find studies concerning the use, effectiveness and potential harm of reflexology on cancer patients.
Results:
From all 821 search results, 29 publications concerning 26 studies with 2465 patients were included in this systematic review. The patients treated with reflexology were mainly diagnosed with breast, lung, gastrointestinal and hematological cancer. Outcomes were mainly pain, quality of life, anxiety, depression, fatigue. The studies had moderate to low quality and reported heterogeneous results: Some studies reported significant improvements in above mentioned outcomes while other studies did not find any changes concerning these endpoints.
Conclusion:
Due to the very heterogeneous results and methodical limitations of the included studies, a clear statement regarding the effectiveness of reflexology on cancer patients is not possible. The current evidence indicates that reflexology is superior to passive control groups for pain, quality of life and fatigue, however, more studies with comparable active control groups are needed.
EaveTubes for Control of Vector Borne Diseases in Côte d’Ivoire
Authors: N’Guessan Raphael , Assi Serge-Brice , Koffi Alphonsine , Phamien Ahoua Alou , Mian Anatole , Achee Nicole L , Fustec Benedicte , Grieco John P. , Liu Fang , Kumar Santosh , Noffsinger Matthew , Hudson Ashley , Möhlmann Tim , Farenhorst Marit 
Published: August 2023

Abstract
Background: Vector control tools, long-lasting insecticidal nets (LLINs) and indoor residual spraying (IRS), have significantly contributed to malaria prevention efforts in sub-Saharan Africa. However, insecticide resistance has seriously hampered their efficacy in recent years and new tools are essential to further progress. In2Care® EaveTubes (ETs) are an inexpensive, new resistance-breaking vector control product under World Health Organization (WHO) evaluation informed by mosquito ecology to efficiently target malaria vectors. By installing ETs in the walls of the house at eave level that funnel the natural airflow, mosquitoes are drawn in by the same heat and odor cues that typically attract them through open eaves. Once inside an ET, mosquitoes are exposed to insecticide-treated netting placed inside the ET. The aim of this study is to test whether ETs as stand-alone tool have an effect on the epidemiology of malaria in villages where houses have been modified with the ET intervention.
Methods: A two-armed, cluster randomized controlled trial will be conducted to evaluate the effect of ETs on clinical malaria incidence in children living in Côte d’Ivoire. Thirty-four villages will be selected based on population size and the proportion of houses suitable for modification with ETs (17 treatment arm (ETs + LLINs, 17 control arm (LLINs only)). Based on the population census, 55 households per cluster with eligible children (i.e. between the ages of 6 months to 8 years old at the start of the study) will be randomly selected for recruitment into the active detection cohorts. In the treatment arm, we will enroll eligible children who reside in ET-treated houses. The intervention and control cohorts will be followed for 4 months for baseline covariate measurements and 24 months with intervention. During case detection visits, blood samples will be taken from all febrile children and tested for malaria infection with rapid diagnostic tests (RDTs). All positive clinical malaria infections will be treated. To estimate the impact of the ET on malaria vector densities, entomological measurements (indoor sampling with CDC traps) will be conducted monthly in 20 clusters (10 ET, 10 Control) in 10 randomly selected households per cluster. To estimate the infectiousness of malaria vectors, sporozoite rates will be measured in subsets of the collected mosquito samples.
Discussion: Findings will serve as an efficacy trial of ETs and will be submitted to the WHO Vector Control Advisory Group (VCAG) for assessment of public health value. Entomological outcomes will also be measured as proxies of malaria transmission to help develop guidelines for the evaluation of future In2Care® ETs products.
Trial registration: ClinicalTrials.gov Identifier: NCT05736679. Registered February 10, 2023.