bluuebunny/crossref_metadata_2025_split huggingface dataset:
The channel selection and coordination considering platform private‐label products
Authors: Chen Yujing , Xu Xiaoping , Zhong Yuanguang 
Published: July 2023

AbstractThis paper studies online channel selection problems related to introducing a platform's private‐label products to the manufacturer's own product. We examine the decision between two prevalent online sales modes: reselling mode and marketplace mode. Our results demonstrate that when the own‐label products are sold in the marketplace mode, both the manufacturer and platform prefer to sell platform's private‐label products in the marketplace mode, but the former prefers a low commission rate and the latter a high rate. However, a “win‐win” zone exists in the marketplace mode for the manufacturer and platform under a moderate commission rate. When the own‐label products are sold in the reselling mode, with the increase in the commission rate, the platform first prefers the reselling mode, then the marketplace mode, and finally the reselling mode. When the own‐label products are sold in the reselling mode, the environmental impact depends on the commission rate and the environmental advantages of the private‐label products. For quantity coordination, when the two products are sold in different modes, the manufacturer and platform can be coordinated under appropriate conditions. For social welfare coordination, even if both products are sold in the reselling mode, the two firms are coordinated under a low carbon emission.
Epigenome‐wide association study using peripheral blood leukocytes identifies genomic regions associated with periodontal disease and edentulism in the Atherosclerosis Risk in Communities study
Authors: Zhao Naisi , Teles Flavia , Lu Jiayun , Koestler Devin C. , Beck James , Boerwinkle Eric , Bressler Jan , Kelsey Karl T. , Platz Elizabeth A. , Michaud Dominique S. 
Published: July 2023

AbstractAimTo investigate individual susceptibility to periodontitis by conducting an epigenome‐wide association study using peripheral blood.Materials and MethodsWe included 1077 African American and 457 European American participants of the Atherosclerosis Risk in Communities (ARIC) study who had completed a dental examination or reported being edentulous at Visit 4 and had available data on DNA methylation from Visit 2 or 3. DNA methylation levels were compared by periodontal disease severity and edentulism through discovery analyses and subsequent testing of individual CpGs.ResultsOur discovery analysis replicated findings from a previous study reporting a region in gene ZFP57 (6p22.1) that was significantly hypomethylated in severe periodontal disease compared with no/mild periodontal disease in European American participants. Higher methylation levels in a separate region in an unknown gene (located in Chr10: 743,992‐744,958) was associated with significantly higher odds of edentulism compared with no/mild periodontal disease in African American participants. In subsequent CpG testing, four CpGs in a region previously associated with periodontitis located within HOXA4 were significantly hypermethylated in severe periodontal disease compared with no/mild periodontal disease in African American participants (odds ratio per 1 SD increase in methylation level: cg11015251: 1.28 (1.02, 1.61); cg14359292: 1.24 (1.01, 1.54); cg07317062: 1.30 (1.05, 1.61); cg08657492: 1.25 (1.01, 1.55)).ConclusionsOur study highlights epigenetic variations in ZPF57 and HOXA4 that are significantly and reproducibly associated with periodontitis. Future studies should evaluate gene regulatory mechanisms in the candidate regions of these loci.
Evaluating the spatial application of multivariable flood damage models
Authors: Paulik Ryan , Zorn Conrad , Wotherspoon Liam 
Published: July 2023

AbstractFlood damage arises from complex interactions between flooding processes and socio‐economic elements. Damage assessments for elements such as residential buildings rely on a modelled representation of local damage factors. Multivariable model approaches are well suited for damage prediction using detailed information on flood hazard and building characteristics. While broad explanatory variable ranges can improve model prediction performance, model transfer across geographical contexts often causes performance loss. This study aims to determine if increasing explanatory damage variables in a multivariable model improves residential building damage prediction and whether models based on local variables transfer between locations. We used empirical damage observations from six flood events to train and evaluate random forest regression model prediction performance. Spatial transfer is tested by splitting event datasets with trained models applied to original and external events. Variable analysis demonstrates model performance improvement with up to seven flood hazard and building characteristics, decreasing thereafter. Event models showed highest prediction precision for the original event, while models trained on all events transfer with comparable predictions for urban stormwater flooding. Prediction precision reduces when models transfer between locations affected by different flood types. This indicates flood damage models must replicate variability in local damage factors for reliable spatial transfer.
The third generation barbed lifting threads: Added value of hyaluronic acid
Authors: Ziade Georges , Daou Dayane , Karam Desiree , Tsintsadze Murat 
Published: July 2023

AbstractIntroductionFacial thread lifting is a highly demanded procedure in esthetic clinics worldwide. The aim of this retrospective study is to evaluate the clinical effectiveness and overall patients’ satisfaction of a new generation of barbed threads, in which a hyaluronic acid (HA) coat was added to the PLLA/PCL threads and compare the results with PLLA/PCL threads without HA.Materials and methodsTwenty patients treated with the PLLA/PCL threads with or without hyaluronic acid (HA) were compared for FaceQ scales: Age appraisal, psychological function, skin satisfaction, satisfaction with facial appearance, appraisal lines of nasolabial folds, satisfaction of lower face, and jaw were compared at baseline, 4 and 12 months post‐treatment. Early impact on life and the skin adverse effects were assessed 1 week post‐treatment. Finally, patients and two physicians provided the GAIS score at 4 and 12 months and a comparison was made between the two groups.ResultsThere was a statistically significant improvement in all scales of FaceQ for all included patients at baseline and at 4 and 12 months post‐treatment. Importantly, there were less skin‐related adverse effects such as skin redness, uneven tone, irregular surface, burning, and itching sensation at a recovery period (1 week post‐treatment) in the group receiving HA‐containing threads.ConclusionA notably higher long‐term improvement in aging appearance, satisfaction with face appearance, lower jaw and face as well as GAIS was seen in the group treated with HA‐containing threads compared to the other treatment arm.
Using 3% retinol peeling and cosmeceuticals for the aesthetic wellness of the oncological patient after precautionary endocrine treatment: A case series
Authors: Belmontesi M. , Noberasco C. 
Published: July 2023

AbstractBackgroundRoughness, sagging, and skin rash are common in patients with breast cancer treated with LH‐RH analog plus tamoxifen or aromatase inhibitors as adjuvant postsurgical endocrine therapy. The use of topical retinol (vitamin A) has shown to be an efficacious cosmetic treatment.AimsPeeling with an advanced retinol peel formulation based on 3% retinol, 4% triethyl citrate, 0.1% aminophil, bisabolol, and 1% vitamin E acetate, in a vehicle in an alcoholic solution has been successfully used to ameliorate skin appearance on subjects with photodamage and in the aged population. We aimed to verify its use during adjuvant chemotherapy.PatientsFour subjects experiencing skin issues during postsurgical adjuvant therapy for their breast cancer received retinol peel at least 6 weeks after stopping their postsurgery therapy as a low invasive aesthetic medical treatment to be used both at the dermatology desk and at home.ResultsRetinol peel was effective, safe, and well‐tolerated, improving skin brightness and firmness in all the patients, since 4 weeks after the beginning of the treatment. Patients declared to be satisfied with the treatment and their skin appearance letting them feel better for cancer recovery, too.ConclusionThese preliminary observations suggest that the use of an advanced retinol peel formulation might improve skin appearance in women experiencing skin damages caused by adjuvant therapy after breast cancer surgery.
Experimental study on the effect and mechanism of adipose stem cell‐derived exosomes combined with botulinum toxin A on skin trauma in rats
Authors: Zheng Hui‐Hui , Ben Xin‐Yu , Wang Ya‐Ru , Tian Meng‐Si , Meng Qing‐wen , Li De‐Xian , Wen Shi‐Lei , Ni Pan‐Li , Hao Jing‐Wen , Zhang Quan‐Peng , Yang Juan , Liu Qi‐Bing , Li Qi‐Fu , Yi Xi‐Nan 
Published: July 2023

AbstractBackgroundAdipose stem cell‐derived exosomes (ADSC‐EXO) and botulinum toxin type A (BTX‐A) individually showed a therapeutic effect on skin wound repair.AimsThis study investigated their synergistic effect on promoting skin wound healing in vitro and in vivo and the underlying molecular events.MethodsADSCs were isolated from Sprague–Dawley (SD) rats to obtain ADSC‐EXO by ultrafiltration and ultracentrifugation and were confirmed using nanoparticle tracking analysis and transmission electron microscopy. Human skin fibroblasts (HSF) were cultured and treated with or without ADSC‐EXO, BTX‐A, or their combination. Changes in cell phenotypes and protein expression were analyzed using different in vitro assays, and a rat skin wound model was used to assess their in vivo effects.ResultsThe isolated ADSC‐EXO from primarily cultured ADSCs had a circular vesicle shape with a 30–180 nm diameter. Treatment of HSF with ADSC‐EXO and/or BTX‐A significantly accelerated HSF migration in vitro and skin wound healing in a rat model. Moreover, ADSC‐EXO plus BTX‐A treatment dramatically induced VEGFA expression but reduced COL III and COL I levels in vivo. ADSC‐EXO and/or BTX‐A treatment significantly upregulated TGF‐β3 expression on Day 16 after surgery but downregulated TGF‐β1 expression, suggesting that ADSC‐EXO plus BTX‐A promoted skin wound healing and reduced inflammatory cell infiltration.ConclusionsThe ADSC‐EXO plus BTX‐A treatment demonstrated a synergistic effect on skin wound healing through upregulation of VEGF expression and the TGF‐β3/TGF‐β1 and COL III/COL I ratio.
Rural/urban differences in health care utilization and costs by perinatal depression status among commercial enrollees
Authors: Pollack Lisa M. , Chen Jiajia , Cox Shanna , Luo Feijun , Robbins Cheryl L. , Tevendale Heather , Li Rui , Ko Jean Y. 
Published: July 2023

AbstractPurposeTo understand differences in health care utilization and medical expenditures by perinatal depression (PND) status during pregnancy and 1‐year postpartum overall and by rural/urban status.MethodsWe estimated differences in health care utilization and medical expenditures by PND status for individuals with an inpatient live‐birth delivery in 2017, continuously enrolled in commercial insurance from 3 months before pregnancy through 1‐year postpartum (study period), using MarketScan Commercial Claims data. Multivariable regression was used to examine differences by rurality.FindingsTen percent of commercially insured individuals had claims with PND. A smaller proportion of rural (8.7%) versus urban residents (10.0%) had a depression diagnosis (p < 0.0001). Of those with PND, a smaller proportion of rural (5.5%) versus urban residents (9.6%) had a depression claim 3 months before pregnancy (p < 0.0001). Compared with urban residents, rural residents had greater differences by PND status in total inpatient days (rural: 0.7, 95% confidence interval [CI]: 0.6–0.9 vs. urban: 0.5, 95% CI: 0.5–0.6) and emergency department (ED) visits (rural: 0.7, 95% CI: 0.6–0.9 vs. urban: 0.5, 95% CI: 0.4–0.5), but a smaller difference by PND status in the number of outpatient visits (rural: 9.2, 95% CI: 8.2–10.2 vs. urban: 13.1, 95% CI: 12.7–13.5). Differences in expenditures for inpatient services by PND status differed by rural/urban status (rural: $2654; 95% CI: $1823–$3485 vs. urban: $1786; 95% CI: $1445–$2127).ConclusionsCommercially insured rural residents had more utilization for inpatient and ED services and less utilization for outpatient services. Rural locations can present barriers to evidence‐based care to address PND.
Effects of past and present microclimates on northern and southern plant species in a managed forest landscape
Authors: Christiansen Ditte Marie , Strydom Tanya , Greiser Caroline , McClory Ryan , Ehrlén Johan , Hylander Kristoffer 
Published: July 2023

AbstractQuestionsNear‐ground temperatures can vary substantially over relatively short distances, enabling species with different temperature preferences and geographical distributions to co‐exist within a small area. In a forest landscape, the near‐ground temperatures may change due to management activities that alter forest density. As a result of such management activities, current species distributions and performances might not only be affected by current microclimates, but also by past conditions due to time‐lagged responses.LocationSweden.MethodsWe examined the effects of past and current microclimates on the distributions and performances of two northern, cold‐favoured, and two southern, warm‐favoured, plant species in 53 managed forest sites. Each pair was represented by one vascular plant and one bryophyte species. We used temperature logger data and predictions from microclimate models based on changes in basal area to relate patterns of occurrence, abundance, and reproduction to current and past microclimate.ResultsThe two northern species were generally favoured by microclimates that were currently cold, characterised by later snowmelt and low accumulated heat over the growing season. In contrast, the two southern species were generally favoured by currently warm microclimates, characterised by high accumulated heat over the growing season. Species generally had higher abundance in sites with a preferred microclimate both in the past and present, and lower abundance than expected from current conditions, if the past microclimate had changed from warm to cold or vice versa, indicating time‐lags in abundance patterns of the species.ConclusionsOur results show a potential importance of past and present microclimate heterogeneity for the co‐existence of species with different temperature preferences in the same landscape and highlight the possibility to manage microclimates to mitigate climate change impacts on forest biodiversity.
A survey on oral health‐related standard of care for head and neck cancer patients in the EU
Authors: Bertl Kristina , Kogelnik Sophie Livia , Kukla Edmund , Herrmann Harald , Schneider Steffen , Altorjai Gabriela , Stavropoulos Andreas 
Published: July 2023

AbstractObjectiveTo map oral health‐related standard of care in the context of head and neck cancer (HNC) treatment across the European Union (EU).Materials and MethodsSix hundred and ninety centers across the European Union were contacted. The questionnaire contained questions focusing on the team/department structure, HNC treatment planning routines, and assessment and handling of dental treatment needs prior to cancer treatment.ResultsEighty‐seven centers across the EU responded. Department structure and number of HNC patients treated per year varied widely and dental professionals are included as part of the team in about 25% of the centers. Standard of care, in terms of dental assessment and preventive dentistry routines, such as recording an orthopantomogram, offering dental treatment, and providing a radiation protection splint and splint for fluoride application, differed significantly among the European regions. Independent of the region, these aspects are positively affected if dental professionals are part of the interdisciplinary treatment team and if dental treatment is offered within the center.ConclusionDental professionals are still only to a very limited extent included in interdisciplinary treatment planning teams of HNC patients. However, their inclusion and/or offering dental treatment within the same hospital/center appears to improve oral health‐related standard of care.Clinical RelevanceInclusion of dental professionals in treatment planning teams of HNC patients appears to improve oral health‐related standard of care within HNC treatment.
Contemporary concepts on periodontal complications from prosthetic and restorative therapies
Authors: Gracis Stefano , Llobell Arturo , Chu Stephen J. 
Published: July 2023

AbstractThe clinical outcome of every prosthetic and restorative procedure depends on the maintenance of a healthy periodontium. It is, therefore, important that the prosthodontist and restorative dentist cause no harm or permanent damage to the underlying hard and soft tissues when performing clinical procedures necessary to carry out the planned treatment. Several factors involved in these procedures have been described to have an impact on gingival health. For the present article, a selection of four of these factors are presented with the goal of evaluating the current trends and their influence on periodontal structures: (1) tooth preparation configuration and apical extension, (2) gingival tissue sulcular expansion/retraction, (3) prosthetic contours, and (4) prosthesis marginal adaptation and the consequences of excess cement remnants. Based on the available scientific evidence and clinical experience, recommendations for the practitioner are given.
Feasibility and Acceptability of LNG 1.5 mg as an On‐Demand Pericoital Contraceptive in Ghana
Authors: McCann Brent , Liang Tina , Ramarao Saumya , Kuffour Emmanuel , Ankomah Augustine , Vandermark Moore Jessica , Bruce Henry , Essandoh Pius , Boateng Angela 
Published: July 2023

AbstractGlobally, there is a need for more family planning method options as currently, available options do not adequately meet the needs of women, specifically those who have infrequent sex. Levonorgestrel (LNG) 1.5 mg is widely available as emergency contraception pills (ECP), and recent research has shown that certain women take it as their main form of contraception. Furthermore, limited studies have found repeat, on‐demand use safe and efficacious.This 12‐month prospective, single‐arm, interventional study in Ghana tested whether a single LNG 1.5 mg on‐demand or pericoital (“around the time of sex”) dose contraceptive was acceptable to women who have infrequent sex and if pharmacy provision was feasible. The study sample (1,890) comprised women of reproductive age recruited from urban areas, having infrequent sex (i.e., coital frequency ≤ 6× per month), and not using any other modern methods except condoms or ECP at the time of study inclusion.Results indicated that there is demand and acceptability for a pericoital pill and that pharmacy provision is feasible. Furthermore, precoital use of the pill had high levels of satisfaction and was popular with new users. Adding LNG 1.5 mg for pericoital use to the family planning method mix has the potential to address an important segment of the population currently underserved, decrease unwanted pregnancies, and increase modern contraceptive prevalence rates.
The science…or not behind deferrals of blood donors with a history of cancer
Authors: Gammon Richard R. , Hopkins Courtney , Mathur Gagan , Rossmann Susan N. , Sayers Merlyn , Straus Todd 
Published: July 2023

AbstractBackgroundIn the United States (US), each blood center's medical director sets policy for donors with a cancer history.Study Design and MethodsA subgroup of America's Blood Centers' (ABC) Scientific, Medical, and Technical Committee developed a survey to measure the determination of eligibility, policies for deferral and/or lookback when a donor reports a current diagnosis or history of cancer. A 31‐question survey was sent to 47 ABC blood centers in North America via email. Survey results were compiled and literature evaluating the risk of cancer transmission by transfusion was reviewed.ResultsResponses were received from 37 centers (79%). Donors with a history of carcinoma or sarcoma who had completed treatment were accepted at 73% of centers with no further deferral. Donors with a history of leukemia or lymphoma were permanently deferred at 76% of centers. Donors with a myelodysplastic or myeloproliferative syndrome were deferred permanently at 86% of centers. Handling of donors with high white cell counts varied. Donors with cancer not in active treatment (i.e., prostate cancer) were subject to various deferrals. Center response to post‐donation reports of cancer vary widely. Literature review yielded no evidence of transfusion‐transmitted cancer.ConclusionCancer deferral policies vary widely among blood centers, and are not generally based on evidence, but on some aspect of the precautionary principle. As the donor population ages and so becomes more at risk of cancer, this approach may further reduce the available donor pool.
Climatic regulation of atmospheric mercury deposition: Evidence from mercury isotopes in an alpine peat core
Authors: Xue Wen , Yin Runsheng , Kwon Sae Yun , Peng Haijun , Chen Di , Zeng Mengxiu , Fang Linchuan 
Published: July 2023

Abstract
Mercury is a global pollutant that can undergo long-range transport in the atmosphere. While anthropogenic activities have largely increased atmospheric Hg emission and deposition since global industrialization, mechanisms governing the atmospheric Hg cycle in preindustrial periods remain unclear. Alpine peatlands receive Hg mainly from atmospheric Hg deposition and are sensitive to climatic changes, therefore alpine peat cores can be a useful archive for understanding the relationship between atmospheric Hg deposition and climate change. Here we reconstruct a 1200-year Hg deposition record based on a core drilled from an ombrotrophic peat bog in Yunnan-Guizhou Plateau, SW China. This core shows a dramatic change of Hg deposition fluxes (30.3–515 μg/m2/yr) associated with variable Hg isotopic composition (δ202Hg: –1.02‰ to –2.01‰; Δ199Hg: –0.16‰ to –0.50‰; Δ200Hg: –0.08‰ to 0.07‰). Using a Δ200Hg-based model, deposition fluxes of atmospheric Hg(0) and Hg(II) were estimated, which vary coherently with climatic indices (e.g., temperature, precipitation, and monsoon intensity). Results of this study imply that atmospheric Hg deposition in SW China is governed by two climate scenarios. In warm-house climates, low precipitation intensity and vegetation growth rates in SW China caused low atmospheric Hg(II) and Hg(0) deposition fluxes, respectively. In cold-house climates, high precipitation intensity and vegetation growth rates caused high atmospheric Hg(II) and Hg(0) deposition fluxes. This study highlights that climate changes can have a strong control on atmospheric Hg deposition.