bluuebunny/crossref_metadata_2025_split huggingface dataset:
WITHDRAWN: On the numerical solution of high order stable difference schemes for nonlinear system of sine-Gordon equations in the weak sense
Authors: Yildirim Ozgur 
Published: March 2023

Abstract
In the present paper numerical solution of the coupled system of sine-Gordon equations are studied in the weak sense. A first order and two second order of accuracy unconditionally stable difference schemes corresponding to the system of sine-Gordon equations are considered. Solutions of these difference schemes are obtained in the space of distributions by variational methods. The fixed point theory and finite difference method is used together in the implementations of numerical experiments which verify theoretical statements.
Light treatment ameliorates sub-chronic MK-801-induced cognitive deficits in mice through up-regulating BDNF/p-CREB/p-ERK signaling pathway
Authors: Cui Keke , Zhou Yiying , Zhang Lizhi , Ying Yudong , Xue Yan , Gu Jiajie , Zhang Xiaoqin , Wang Qinwen , Shen Haowei , Zhou Wenhua , Wang Zhengchun 
Published: March 2023

Abstract

Cognitive impairment associated with schizophrenia (CIAS) is regarded as a core symptom of the illness, and there is still no effective treatment. Light plays an important role in regulation of cognitive functions. However, whether light treatment (LT) can improve CIAS remains unknown. The current study investigated the efficacy of LT on CIAS and explored the underlying molecular mechanisms in a CIAS model. The CIAS and control group were sub-chronically injected with MK-801 and saline respectively, and the LT/CIAS group were CIAS mice exposed to LT (3,000 Lux, 2 hr/day, 3 weeks). Results showed that the performance of LT/CIAS mice significantly improved in the novel object recognition test, novel location recognition test and Morris water maze compared with the CIAS group. And the behavioral improvement effects of LT could last over 4 weeks after LT was terminated. Golgi-cox staining revealed that the dendritic spine density and morphological complexity of hippocampal CA1 pyramidal neurons were increased after 3 weeks LT. Further research found that higher expression of brain-derived neurotrophic factor (BDNF), accompanied by elevated cAMP response element-binding phosphorylation (p-CREB) level in the hippocampus of LT/CIAS group compared to the CIAS group. Moreover, LT elevated phosphorylated extracellular signal-regulated kinase (p-ERK) level in the hippocampus of LT/CIAS group compared to the CIAS group. Taken together, long term LT ameliorated sub-chronic MK-801-induced cognitive deficits in mice, and the altered dendritic spines density and morphology of CA1 pyramidal neurons were rescued in LT/CIAS mice group, which might associate with up-regulating BDNF/p-CREB/p-ERK signaling pathway in LT/CIAS mice.
Adult child socio-economic status and older parents’ psychosocial outcomes during the COVID-19 pandemic
Authors: Romero K. Renata Flores , Yang Yulin , Green Sharon H. , Gutierrez Sirena , Meza Erika , Torres Jacqueline M. 
Published: March 2023

Abstract
Purpose Older adults’ psychosocial outcomes during the COVID-19 pandemic have been inequitable by socio-economic status (SES). However, studies have focused solely on own SES, ignoring emerging evidence of the relationship between adult child SES and late-life health. We evaluated whether adult child educational attainment – a core marker of SES – is associated with older parents’ psychosocial outcomes during the pandemic.
Methods We used data from the Survey of Health, Aging, and Retirement in Europe (SHARE; 2004-2018) and the SHARE Corona Surveys (2020 and 2021). We included 15,553 respondents > 65 years who had pre-pandemic information on adult child educational attainment, self-reported mental health, and worsened mental health compared to the pre-pandemic period. We used generalized estimating equations adjusted for respondent and family-level characteristics, including respondents’ own SES.
Results Older adults whose adult children averaged levels of educational attainment at or above (vs. below) their country-specific mean had a lower prevalence of nervousness (Prevalence Ratio [PR]: 0.95, 95% Confidence Interval [CI]: 0.91, 0.99), depression (PR: 0.96, 95% CI: 0.92, 1.00), and trouble sleeping (PR: 0.96, 95% CI: 0.92, 1.00) during the pandemic; associations with loneliness were null. Overall associations with worsened mental health as compared to the pre-pandemic period were null. Protective associations were stronger in countries experiencing “high” levels of COVID-19 intensity.
Conclusions Adult child SES may be an important driver of inequities in older adults’ mental health during the COVID-19 pandemic. Policies aimed at improving adult child SES may buffer the adverse psychosocial impacts of societal stressors.
The predictive effect of nomogram constructed based on peripheral blood biochemical indicators on the prognosis of patients with gastric cancer after surgery
Authors: He Shui , Yan Zhi-Qiang , Wang Yang , Shi Qian-Yun , Nie Wei , Yang Fang 
Published: March 2023

Abstract
Objective To investigate the predictive value of aspartate aminotransferase/alanine aminotransferase ratio (SLR) and globulin/prealbumin ratio (GPR) in the prognosis of patients with gastric cancer.
Methods The patients with gastric cancer initially diagnosed at the Affiliated Hospital of Guizhou Medical University from January 2014 to December 2018 were retrospectively analyzed for peripheral blood aspartate aminotransferase and alanine aminotransferase ratio (AST/ALT) and globulin and prealbumin ratio (GLO/PA) serological levels at the time of initial diagnosis, and ROC curves were used to obtain the optimal threshold values of AST/ALT and GLO/PA . Survival rates were compared using Kaplan-Meier survival analysis, and Cox regression models were used for univariate and multivariate analyses, with differences considered statistically significant at P<0.05. A nomogram model for assessing OS-related prognostic factors was established using R software. The performance of the nomogram model was assessed by means of the consistency index (c-index) and the decision curve.
Results The threshold value of SLR was calculated from the ROC curve as 1.433, and the threshold value of GPR was 0.109. Univariate analysis showed that the poor prognostic factors affecting the 3-year OS rate of gastric cancer patients included T grouping, N grouping, M grouping, clinical-stage grouping, SLR grouping, GPR grouping, and tumor size grouping, and the differences were statistically significant (P<0.05). Multifactorial analysis showed that N2-N3 stage, M1 stage, and SLR> 1.433 were independent risk factors for poor prognosis of 3-year OS in gastric cancer patients. It was further used to construct the nomogram prediction chart, calculate the c-index and depict the calibration curve to judge the accuracy of the model, and depict the decision curve to judge the predictive ability of the model.
Conclusion The nomogram prediction chart including SLR can more accurately predict the prognosis of gastric cancer patients.
Exploring potential diagnostic and therapeutic targets for glioma based on the prognostic model of differential expression of pyroxis-related genes
Authors: Yuan Zhengbo , Li Chenglong , Wang Qingbo , Li Zefu 
Published: March 2023

Abstract
Background: Adult glioma is the most common primary nervous system tumor, and there is a direct link between the grade of glioma and the patient's prognosis. Furthermore, its treatment is still very challenging. Pyroptosis is another research direction that has made breakthroughs in recent years, and it has been confirmed that it plays an essential role in various tumors. We are currently focusing on analyzing the data, and clinical data of a large number of pyroptosis genes, exploring the regulatory mechanism of tumor cell pyroptosis and the potential role of pyroptosis in cancer in order to explore potential cancer diagnosis and treatment markers for The pursuit of personalized or precise treatment provides new ideas and directions.
Design: Bioinformatics analysis of GEO database,TCGA database and GSEA data.
Methodology: Differential gene expression, Prognostic Network Construction, Construction of a prognostic model, Differential analysis of tumor microenvironment, immune cell expression, Tumor mutation burden correlation analysis, stem cell correlation analysis, and drug sensitivity analysis.
Conclusions: We have identified differential genes with high mutation frequencies in adult gliomas and critical genes associated with cell scorch and differentially expressed in a different extent of malignant glioma. We are combined with the construction of prognostic models and other methods to reveal potential prediction and therapeutic targets of glioma.
Global Mobility Networks: Design and Development of a Secure and Lightweight Authentication Protocol
Authors: Padmavathi V , Kanimozhi R 
Published: March 2023

Abstract
The increasing use of mobile devices and wireless networks has led to the development of global mobility networks, which enable users to access services and data from anywhere in the world. However, ensuring the security of these networks is a major challenge, as they are vulnerable to various attacks such as eavesdropping, impersonation, and data tampering. To address this challenge, this paper proposes a secure and lightweight authentication protocol for global mobility networks, based on two established cryptographic techniques: the Extensible Authentication Protocol - Transport Layer Security (EAP-TLS) and the Elliptic Curve Digital Signature Algorithm (ECDSA). The proposed authentication protocol consists of several key steps, including user registration, certificate distribution, mutual authentication, and session key generation. The protocol uses EAP-TLS to establish a secure channel between the client and the server, and ECDSA to provide secure digital signatures and key generation. The use of ECDSA ensures that the protocol is resistant to various attacks, such as replay attacks and man-in-the-middle attacks. Additionally, the use of EAP-TLS provides mutual authentication between the client and the server, preventing impersonation attacks. The proposed authentication protocol is designed to be lightweight and efficient, making it practical for use in resource-constrained environments such as mobile devices and wireless networks. The protocol has been evaluated through simulations, and the results demonstrate that it provides strong security guarantees while also being efficient in terms of computational resources and communication overhead. Overall, the proposed authentication protocol provides a practical solution for ensuring the security of global mobility networks, while also being lightweight and efficient enough to be used in resource-constrained environments.
Modeling and Simulation of Coupled Power Transmission Line: A Systematic Approach
Authors: Living O. , Nnamchi S. N. , Mundu M. M. , Ukagwu K. J. , Abdulkarim A. 
Published: March 2023

Abstract
Transmission models are dominated by lumped models, which describe the time dependence of transmission potentials (temperature, current and voltage). The space counterpart is not incorporated into the lumped model. To fill this gap, the present work proposes a distributed or coupled system of thermal and power equations, which depend on both space and time. The coupled system of equations were developed on the balance of thermal and power fluxes around a control volume representing the transmission lines. The Finite Difference Method is pivoted on the Crank Nicolson technique is used to solve the coupled system of equations. Transmission percentage losses ranged from 0.03 to 0.06%, which is consistent with the 5% recommended by the American Transmission Company. In addition, the simulated model results corresponded to field data obtained from the Uganda Electricity Transmission Company Limited (UETCL) on the Bujjagali - Kawanda transmission line. The coupled model system is useful for the simulation and estimation of the power losses in transmission lines respectively and could be implemented in other transmission lines.
Research landscape of radiotherapy for nasopharyngeal carcinoma from 1959 to 2022: a bibliometric analysis.
Authors: Yang Yizhou , Yang Xinqing , Zhang Cuidai , Huang Kaichun , Liu Xuejia , Hong Yingji , Cai Qingxin , Li Mei , Lin Zhixiong 
Published: March 2023

Abstract
Background
Radiotherapy, as the main treatment method for nasopharyngeal carcinoma (NPC), has been innovating over time and no bibliometric study on NPC radiotherapy to date. In the study, the scientific achievements of NPC radiotherapy around the world were evaluated by bibliometric analyses, and the previous research hotspots and future trends were described.
Methods
Original articles related to NPC radiotherapy were obtained from the Web of Science Core Collection. To identify research hotspots and future trends, countries/regions, institutions, journals, references, authors, and keywords were evaluated and visualized by Excel, VOSviewer, and CiteSpace.
Results
From 1959 to 2022, 7139 original articles were collected. The annual publications showed an increasing trend, especially after 2011. Mainland China had the most publications (n = 3719, 52.09%). Sun Yat-sen University has the most publications and citations among institutions. Jun Ma is most productive and SR Baker has the highest co-cited centrality. International Journal of Radiation Oncology-Biology-Physics is the core journal, with most publications, citations and co-citations. Analysis of keywords showed intensity-modulated radiotherapy and chemoradiotherapy were the main keywords, and multicenter was strongest burst.
Conclusion
NPC radiotherapy has attracted increasing attention, and precision and intelligence may be the future trends in this field.
Soft-balanced CAN clustering method
Authors: Xiao Zhangshu , Guo Qinyao , Liu Shigang , Wang Yuyan , Zhou Mingquan , Peng Yali , Zhao Lugang 
Published: March 2023

Abstract
As one of the most outstanding clustering methods, CAN can obtain accurate clustering results by imposing rank constraint to the Laplacian matrix. However, CAN ignores the balanced distribution of real-world sample data. To overcome the disadvantage, we propose a clustering method, referred to as Soft-balanced CAN clustering method (SBCAN) in this paper by introducing a soft-balanced clustering regularizer. Since our proposed method can perform two steps simultaneously with soft-balanced constraint: similarity measurement and data clustering, it can obtain the optimal clustering result. The experiments on six real-world benchmarks demonstrate that our proposed method has superior performance than the state of the art.
Coarctation of Aorta Computational Fluid Dynamics Analysis after Three-Dimensional Reconstruction and Clinical Application
Authors: Ou YangDa , Pan Bo , Lv Tiewei , Liu Lifei , Qin Jin jie , Jin Xin , Tian Jie 
Published: March 2023

Abstract
Objective: To investigate the clinical significance of Computational Fluid analysis in diagnosing and treating coarctation of aorta after three-dimensional reconstruction of CTA.
Methods: The clinical data and imaging data of 40 children with coarctation of aorta and 24 normal children were retrospectively analyzed and summarized, and combined with statistical means and computational fluid dynamics and explored the potential of clinical application.
Results: (1) Computational fluid pressure difference and color Doppler pressure difference analysis were performed in 40 children with coarctation of aortic arch and 24 normal children.There was no significant difference (P > 0.05) in fluid pressure between the 40 patients with coarctation group was 63.1 ± 5.1 mmHg compared with its preoperative color ultrasound pressure difference (64.1 ± 5.2 mmHg), whereas there was a significant difference (P <0.01 ) in fluid pressure between the 40 patients with coarctation of aorta and 24 patients with normal aortic arch was (4.4 ± 1.0) mmHg ;(2) After three-dimensional reconstruction, computational fluid dynamics analysis was performed to analyze the changes in pressure gradient along the aortic path, mainly in the constricted segment, and in-depth discussion and analysis were conducted. The measured pressure drop at the largest constricted segment in the constricted group was greater than 35 mmhg, while the corresponding pressure drop in the normal group children was less than 10 mmhg. The fluid vector graph showed a sharp decrease in pressure in the constricted segment, which was significantly different from the normal group.
Conclusion: Computational fluid dynamics for the diagnosis and treatment of coarctation of aorta is consistent with clinical imaging analysis methods; As a new tool for the diagnosis of coarctation of aorta , Computational fluid dynamics has the same clinical benefits, but also has many advantages that imaging does not have. Its application range is broader. Although the current sample size is not sufficient to develop new diagnostic standards, three-dimensional reconstruction of fluid dynamics analysis can provide a lower cost, less patient pressure, less uncertainty, and more accurate and intuitive assessment of the overall pressure change process of the aortic arch, It has a more comprehensive and systematic guiding significance for the diagnosis and treatment of children with coarctation of aorta.
Application of Laparoscopic Repair for Neonatal Esophageal Neonatal Hiatal Hernia
Authors: Wei Yan-Dong , Feng Zhong , Ma Li-Shuang , Wang Ying , Feng Cui-Zhu , Liu Chao , Zhang Yan-Xia , Li Jing-Na 
Published: March 2023

Abstract
Introduction: With the improvement of prenatal ultrasound, MR and other examination techniques, more and more hiatal hernia has been diagnosed in the neonatal period. At present, surgical indications and surgical opportunities of patients with hiatal hernia are still controversial. Through analyzing the clinical data for 11 neonates with esophageal hiatal hernia diagnosed prenatally and treated with laparoscopic hiatal hernia repair in Affiliated Children’s Hospital, this paper analyzed the laparoscopic surgical treatment and postoperative recovery of these 11 cases, explored the clinical efficacy of laparoscopic esophageal hernia repair for the esophageal hiatal hernia by ultrasonographic diagnosed prenatally, and provided clinical basis for the safety of laparoscopic surgery for prenatal diagnosed hiatal hernia in the neonatal period.
Methods: This paper retrospectively analyzed the clinical data for 11 neonates (7 males and 4 females) with esophageal hiatal hernia diagnosed prenatally and treated with laparoscopic hiatal hernia repair in Affiliated Children’s Hospital of Capital Institute of Pediatrics from May 2015 to January 2022. The age at operation was 2-94 days old, with a median of 4 days old. The body weight was (2.82 ± 0.51) kg. Preoperative chest CT and upper gastrointestinal radiography were performed to confirm the diagnosis of esophageal hiatal hernia. All the 11 children underwent laparoscopic four-hole repair of esophageal hiatal hernia and fundoplication, including 9 cases of Nissen procedure and 2 cases of Thal procedure.
Results: All the 11 operations were performed under laparoscopy without conversion to laparotomy. The operation time of 9 cases of Nissen procedure was (173.0 ± 43.8) mins, and that of Thal procedure was 184 mins and 206 mins, respectively. The time to postoperative diet was (2.54 ± 1.21) days. The hospital stay was (14.09 ± 4.13) days. The 11 neonates were followed up for 7-74 months, with a median of 28 months. No postoperative recurrence of esophageal hiatal hernia occurred. There was no significant difference in height and weight between children of the same age. No obvious vomiting or choking with milk was found.
Conclusion: Prenatal diagnosis of hiatal hernia is of great significance for identifying the types of children as soon as possible after birth, determining treatment plan, and preventing recurrent vomiting, pneumonia, growth retardation and other complications. In order to avoid gastric torsion and incarceration, laparoscopic surgery in the neonatal period is safe and reliable for the treatment of prenatal diagnosed hiatal hernia.
A Hybrid Group Acceptance Sampling plans For Life Tests Based on Gumbel Distribution
Authors: Cheepuri Chinnamamba , B.Srinivasa  , Pr.K.Rosaiah  
Published: March 2023

Abstract
In this research article Hybrid Group Acceptance Sampling Plans (HGASP) are developed for Gumbel distribution based on truncated lifetimes when the lifetime of a product follows a Gumbel distribution. For a given size of the group, the minimum number testers and the acceptance number of groups for the test termination time and particular consumer’s risk are calculated. Operating Characteristic (OC) function values are determined for different quality levels and the minimum ratios of the true average life to the particular life at given producer’s risk are determined. Extensive tables and examples are discussed for illustration purposes.
Serotonin is a Common Thread Linking Different Classes of Antidepressants
Authors: Witt Colby E. , Mena Sergio , Holmes Jordan , Hersey Melinda , Buchanan Anna Marie , Parke Brenna , Saylor Rachel , Honan Lauren E. , Berger Shane N. , Lumbreras Sara , Nijhout Frederik H. , Reed Michael C. , Best Janet , Fadel James , Schloss Patrick , Lau Thorsten , Hashemi Parastoo 
Published: March 2023

Abstract

Depression pathology remains elusive. The monoamine hypothesis has placed much focus on serotonin, but due to the variable clinical efficacy of monoamine reuptake inhibitors, the community is looking for alternative therapies such as ketamine (synaptic plasticity and neurogenesis theory of antidepressant action). There is evidence that different classes of antidepressants may affect serotonin levels; a notion we test here. We measure hippocampal serotonin in mice with voltammetry and study the effects of acute challenges of antidepressants. We find that pseudo-equivalent doses of these drugs similarly raise ambient serotonin levels, despite their differing pharmacodynamics because of differences in Uptake 1 and 2, rapid SERT trafficking and modulation of serotonin by histamine. These antidepressants have different pharmacodynamics but have strikingly similar effects on extracellular serotonin. Our findings suggest that serotonin is a common thread that links clinically effective antidepressants, synergizing different theories of depression (synaptic plasticity, neurogenesis and the monoamine hypothesis).