bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical features and shared mechanisms of chronic gastritis and osteoporosis
Authors: Han Tao , Zhang Yili , Qi Baoyu , Chen Ming , Sun Kai , Qin Xiaokuan , Yang Bowen , Yin He , Xu Aili , Wei Xu , Zhu Liguo 
Published: March 2023

AbstractChronic gastritis (CG) and osteoporosis (OP) are common and occult diseases in the elderly and the relationship of these two diseases have been increasingly exposed. We aimed to explore the clinical characteristics and shared mechanisms of CG patients combined with OP. In the cross-sectional study, all participants were selected from BEYOND study. The CG patients were included and classified into two groups, namely OP group and non-OP group. Univariable and multivariable logistic regression methods were used to evaluate the influencing factors. Furthermore, CG and OP-related genes were obtained from Gene Expression Omnibus (GEO) database. Differentially expressed genes (DEGs) were identified using the GEO2R tool and the Venny platform. Protein–protein interaction information was obtained by inputting the intersection targets into the STRING database. The PPI network was constructed by Cytoscape v3.6.0 software again, and the key genes were screened out according to the degree value. Gene function enrichment of DEGs was performed by Webgestalt online tool. One hundred and thirty CG patients were finally included in this study. Univariate correlation analysis showed that age, gender, BMI and coffee were the potential influencing factors for the comorbidity (P < 0.05). Multivariate Logistic regression model found that smoking history, serum PTH and serum β-CTX were positively correlated with OP in CG patients, while serum P1NP and eating fruit had an negative relationship with OP in CG patients. In studies of the shared mechanisms, a total of 76 intersection genes were identified between CG and OP, including CD163, CD14, CCR1, CYBB, CXCL10, SIGLEC1, LILRB2, IGSF6, MS4A6A and CCL8 as the core genes. The biological processes closely related to the occurrence and development of CG and OP mainly involved Ferroptosis, Toll-like receptor signaling pathway, Legionellosis and Chemokine signaling pathway. Our study firstly identified the possible associated factors with OP in the patients with CG, and mined the core genes and related pathways that could be used as biomarkers or potential therapeutic targets to reveal the shared mechanisms.
Remote First-Language Assessment: Feasibility Study With Vietnamese Bilingual Children and Their Caregivers
Authors: Dam Quynh Diem , Pham Giang T. 
Published: March 2023

Purpose:
There is a shortage of bilingual speech-language pathologists (SLPs) in the United States. For Vietnamese, less than 1% of SLPs speak the language compared with a Vietnamese American population of > 2.1 million. This study examines the feasibility and social validity of remote child language assessment with the help of a caregiver to address the need for first language assessments among Vietnamese-speaking children.

Method:
Twenty-one dyads of caregivers and typically developing children (aged 3–6 years) completed two assessment sessions in their first language, Vietnamese, using Zoom videoconferencing. Sessions were counterbalanced between two conditions in which either the clinician or the caregiver was the task administrator. Children's language samples were elicited using narrative tasks. Social validity was also assessed through caregiver and child questionnaires at the end of each session.

Results:
There were no significant differences between conditions on language sample measures nor the measures of social validity. Both caregivers and their children felt positively about the sessions. The caregivers' feelings were related to their perception of children's feelings about the sessions. Children's feelings were related to their Vietnamese language proficiency, caregiver-reported language ability, and whether they were born outside of the United States.

Conclusions:
Findings build the evidence base for telepractice as an effective and socially valid service delivery model for bilingual children in the United States. This study supports the potential for caregivers as task administrators in a telepractice setting, making assessment in a child's first language more feasible and accessible. Future investigation is needed to extend results to bilingual populations with disorders.
Initial Results of a Direct Aspiration First-Pass Technique to Treat Acute Ischemic Stroke Patients in Nepal
Authors: Phuyal Subash , Paudel Raju , Lamsal Ritesh , Thapa Lekhjung , Maharjan Anzil Mani Singh , Gajurel Bikram Prasad 
Published: March 2023

Abstract
Objective Endovascular therapy has become the mainstay of treatment of acute ischemic stroke (AIS) due to large vessel occlusion. A direct aspiration first-pass technique (ADAPT) using large bore aspiration catheters has been introduced as a rapid, simple method for achieving good revascularization and good clinical outcomes. The aim of this study was to assess the safety and efficacy of ADAPT in the treatment of AIS due to large-vessel occlusion in the Nepali patient population.
Materials and Methods Retrospective data were collected for all consecutive patients treated for AIS with ADAPT from March 2019 through January 2021 at two hospitals. Outcomes were successful revascularization (modified thrombolysis in cerebral infarction score of 2b-3), time to revascularization, procedural complications, and good clinical outcome (modified Rankin Scale score of 0 to 2) and mortality at 90 days.
Statistical Analysis Retrospective data were collected and descriptive statistics were calculated.
Results Sixty-eight patients treated for AIS with ADAPT were included. The median National Institutes of Health Stroke Scale score at presentation was 13 (IQR 10–13.25). The median time from arterial puncture to revascularization was 40 minutes (IQR 30–45). Successful revascularization was achieved in 54 patients (79.4%). No cases of symptomatic intracranial hemorrhage occurred. At 90-day follow-up, good clinical outcome was achieved in 57 patients (83.8%), and 4 patients died (5.9%).
Conclusion A direct aspiration first pass technique appears to be a fast, simple, safe, and effective method for the management of AIS in the Nepali patient population.
Direct quotations in the rhetorical structure of literature PhD thesis introductions
Authors: Ono Masumi , Petrić Bojana 
Published: March 2023

Abstract
Direct quotation (DQ) use varies considerably across disciplines, from complete absence in hard sciences to
relative frequency in social sciences. This study investigates DQs in literature, focusing on PhD thesis introductions in English.
A corpus of 15 introductions tagged for move-and-step genre analysis was used to investigate DQ frequency, their distribution in
the rhetorical structure of introductions, and source text types used for DQs. The findings show that (i) DQs are the most common
source use practice in the corpus; (ii) DQs are concentrated in three rhetorical steps: reviewing previous research, presenting
the analysed literary work, and making topic generalisations; and (iii) source text type used for DQs is associated with specific
rhetorical steps. These findings suggest that DQs are essential for the realisation of the rhetorical purpose of the steps which
carry them and for knowledge construction in literature PhD theses.
Exploring the use of modality in EFL learners’ writing
Authors: Ostovar-Namaghi Seyyed Ali , Khorram Fatemeh , Moezzipour Farhad 
Published: March 2023

Abstract
Due to prevalence of formal analysis in language education, the implications of Systemic Functional Grammar has
largely been ignored by materials and methods of language education. To illustrate the inadequacies of formal analysis and make a
case for functional analysis and assessment of writing samples, this study aims at exploring the use of modality in a random
sample of expository essays written in an EFL context. To this end, 20 expository essays, written by undergraduate students of
English language and literature, were randomly obtained from writing instructors and professors teaching in the English department
of Shahrood University of Technology (SUT), Iran. Leaners’ use of modality was then analyzed in line with the framework presented
by Halliday & Matthiessen (2014). Analysis revealed learners’ lack of variation in
the expression of uncertainties and doubts and as such lack of mastery over modality since they tended to express their opinions
as implicit and as objective as possible. There seems to be a link between this problem and the dominance of formal analysis in
teaching and assessing writing; hence, the findings of this study have clear implications for teaching instruction in this context
and other similar contexts, where the implications of systemic functional grammar for language education seem to be ignored.
The Essential Qualities for an Arbitrator
Authors: Legum Barton , Motin Clara 
Published: March 2023

Abstract
This note provides a practitioner’s perspective on one of the most important, if not the most important, decision in any arbitration: selection of the arbitrators. An advantage of arbitration over other binding dispute resolution mechanisms is the ability for parties to select arbitrators best suited to the case at hand. Each case is generally different, however. Arbitrators with specific qualities may suit them for a given case. This note provides a practical framework for identifying, vetting and selecting arbitrators who are right for a case. It first identifies factors a party may wish to consider in determining the qualities required. It then elaborates a practical approach for identifying candidates possessing such qualities, performing due diligence on those candidates and making the final selection.
The potential for stabilizing Amundsen Sea glaciers via underwater curtains
Authors: Wolovick Michael , Moore John , Keefer Bowie 
Published: March 2023

Abstract
Rapid sea level rise due to an ice sheet collapse has the potential to be extremely damaging the coastal communities and infrastructure. Blocking deep warm water with thin flexible buoyant underwater curtains may reduce melting of buttressing ice shelves and thereby slow the rate of sea level rise. Here, we use new multibeam bathymetric datasets, combined with a cost–benefit model, to evaluate potential curtain routes in the Amundsen Sea. We organize potential curtain routes along a “difficulty ladder” representing an implementation pathway that might be followed as technological capabilities improve. The first curtain blocks a single narrow (5 km) submarine choke point that represents the primary warm water inflow route towards western Thwaites Glacier, the most vulnerable part of the most vulnerable glacier in Antarctica. Later curtains cross larger and deeper swaths of seabed, thus increasing their cost, while also protecting more of the ice sheet, increasing their benefit. In our simple cost–benefit analysis, all of the curtain routes achieve their peak value at target blocking depths between 500 and 550 m. The favorable cost–benefit ratios of these curtain routes, along with the trans-generational and societal equity of preserving the ice sheets near their present state, argue for increased research into buoyant curtains as a means of ice sheet preservation, including high-resolution fluid-structural and oceanographic modeling of deep water flow over and through the curtains, and coupled ice-ocean modeling of the dynamic response of the ice sheet.
Differences in Outcomes and Health Care Resource Utilization After Surgical Intervention for Metastatic Spinal Column Tumor in Safety-Net Hospitals
Authors: Elsamadicy Aladine A. , Koo Andrew B. , David Wyatt B. , Reeves Benjamin C. , Sherman Josiah J.Z. , Craft Samuel , Hersh Andrew M. , Duvall Julia , Lo Sheng-Fu Larry , Shin John H. , Mendel Ehud , Sciubba Daniel M. 
Published: March 2023

Study Design.
Observational cohort study.

Objective.
The aim of this study was to investigate the association between safety-net hospital (SNH) status and hospital length of stay (LOS), cost, and discharge disposition in patients undergoing surgery for metastatic spinal column tumors.

Summary of Background Data.
SNHs serve a high proportion of Medicaid and uninsured patients. However, few studies have assessed the effects of SNH status on outcomes after surgery for metastatic spinal column tumors.

Patients and Methods.
This study was performed using the 2016-2019 Nationwide Inpatient Sample database. All adult patients undergoing metastatic spinal column tumor surgeries, identified using ICD-10-CM coding, were stratified by SNH status, defined as hospitals in the top quartile of Medicaid/uninsured coverage burden. Hospital characteristics, demographics, comorbidities, intraoperative variables, postoperative complications, and outcomes were assessed. Multivariable analyses identified independent predictors of prolonged LOS (>75th percentile of cohort), nonroutine discharge, and increased cost (>75th percentile of cohort).

Results.
Of the 11,505 study patients, 24.0% (n = 2760) were treated at an SNH. Patients treated at SNHs were more likely to be Black-identifying, male, and lower income quartile. A significantly greater proportion of patients in the non-SNH (N-SNH) cohort experienced any postoperative complication [SNH: 965 (35.0%) vs. N-SNH: 3535 (40.4%), P = 0.021]. SNH patients had significantly longer LOS (SNH: 12.3 ± 11.3 d vs. N-SNH: 10.1 ± 9.5 d, P < 0.001), yet mean total costs (SNH: $58,804 ± 39,088 vs. N-SNH: $54,569 ± 36,781, P = 0.055) and nonroutine discharge rates [SNH: 1330 (48.2%) vs. N-SNH: 4230 (48.4%), P = 0.715) were similar. On multivariable analysis, SNH status was significantly associated with extended LOS [odds ratio (OR): 1.41, P = 0.009], but not nonroutine discharge disposition (OR: 0.97, P = 0.773) or increased cost (OR: 0.93, P = 0.655).

Conclusions.
Our study suggests that SNHs and N-SNHs provide largely similar care for patients undergoing metastatic spinal tumor surgeries. Patients treated at SNHs may have an increased risk of prolonged hospitalizations, but comorbidities and complications likely contribute greater to adverse outcomes than SNH status alone.

Level of Evidence.
3.
High Risk Factors for Placenta Accreta Other than Pregnancy and Their Impact on Patient Prognosis
Authors: Yang Xinrui , Zheng Weiran , Yan Jie , Yang Huixia 
Published: March 2023

AbstractObjectiveThis study aimed to determine the most pertinent factors responsible for placenta accreta spectrum disorders in patients without any history of pregnancy and evaluate their prognostic implications.MethodsThis retrospective cohort study included 1009 patients diagnosed with placenta accreta spectrum disorders based on standardized diagnostic criteria across 10 tertiary hospitals in China between January 1, 2018, and December 31, 2018; 45 patients without a history of pregnancy were selected. The collected data mainly included demographic characteristics (including age, operative history, and ultrasound findings) and maternal-fetal outcomes (including any history of intraoperative bleeding, blood transfusion details, maternal-fetal complications, and fetal Apgar scores). SPSS 24.0 was used for statistical analyses. The Mann-WhitneyUtest and logistic regression were performed; a two-tailedP< 0.050 was considered statistically significant.ResultsUltrasound-based detection of placenta previa (χ2= 9.911,P= 0.003) showed a strong association with placenta accreta spectrum types. The severity of placenta accreta spectrum was directly proportional to the likelihood of having coexistent complete placenta previa (χ2= 11.626,P= 0.009) and being diagnosed by ultrasound (χ2= 5.449,P= 0.047). Blood transfusion also impacted placenta accreta spectrum types in relation to maternal prognosis (χ2= 8.785,P= 0.004). On univariate analysis, older age led to more complications (U= 82.000,P= 0.011), and in vitro fertilization-embryo transfer caused more intraoperative bleeding (U= 91.500,P= 0.007). Although the 1- and 5-minute Apgar scores were statistically significant, the rates of neonatal asphyxia did not differ (P> 0.050). Endometrial damage led to lower Apgar scores on both univariate (1 minute:U= 29.500,P= 0.027; and 5 minutes:U= 33.500,P= 0.031) and multivariate (1 minute:β= −1.510, 95% confidence interval, −2.639 to 0.381,P= 0.010; and 5 minutes:β= −0.968, 95% confidence interval, −1.779 to 0.157,P= 0.021) analyses.ConclusionIn patients who had no history of pregnancy, placenta previa was a strong risk factor for severe placenta accreta spectrum disorders. Endometrial damage led to lower Apgar scores; this warrants greater consideration in the clinic.
Cell-matrix interactions control biliary organoid polarity, architecture, and differentiation
Authors: Fiorotto Romina , Mariotti Valeria , Taleb Shakila Afroz , Zehra Syeda A. , Nguyen Mytien , Amenduni Mariangela , Strazzabosco Mario 
Published: March 2023

Background and Aims:
Cholangiopathies are an important cause of morbidity and mortality. Their pathogenesis and treatment remain unclear in part because of the lack of disease models relevant to humans. Three-dimensional biliary organoids hold great promise; however, the inaccessibility of their apical pole and the presence of extracellular matrix (ECM) limits their application. We hypothesized that signals coming from the extracellular matrix regulate organoids’ 3-dimensional architecture and could be manipulated to generate novel organotypic culture systems.

Approach and Results:
Biliary organoids were generated from human livers and grown embedded into Culturex Basement Membrane Extract as spheroids around an internal lumen (EMB). When removed from the EMC, biliary organoids revert their polarity and expose the apical membrane on the outside (AOOs). Functional, immunohistochemical, and transmission electron microscope studies, along with bulk and single-cell transcriptomic, demonstrate that AOOs are less heterogeneous and show increased biliary differentiation and decreased expression of stem cell features. AOOs transport bile acids and have competent tight junctions. When cocultured with liver pathogenic bacteria (Enterococcus spp.), AOOs secrete a range of proinflammatory chemokines (ie, MCP1, IL8, CCL20, and IP-10). Transcriptomic analysis and treatment with a beta-1-integrin blocking antibody identified beta-1-integrin signaling as a sensor of the cell-extracellular matrix interaction and a determinant of organoid polarity.

Conclusions:
This novel organoid model can be used to study bile transport, interactions with pathobionts, epithelial permeability, cross talk with other liver and immune cell types, and the effect of matrix changes on the biliary epithelium and obtain key insights into the pathobiology of cholangiopathies.
Validation of the Baveno VI criteria to rule out high-risk varices using hepatic shear-wave elastography
Authors: Castro Filho Élio C. , Fernandes Flávia F. , Villela-Nogueira Cristiane , Madeira Eduardo , Barros Fernando , Luz Rodrigo , Pereira Gustavo Henrique , Perazzo Hugo 
Published: March 2023

Introduction and objectives
Liver stiffness measurement (LSM) by transient elastography has been validated to predict high-risk varices (HRV). We aimed to evaluate the accuracy of shear-wave elastography (SWE) and platelet count (Baveno VI criteria) to rule out HRV in patients with compensated advanced chronic liver disease (c-ACLD).

Methods
This retrospective study analyzed data of patients with c-ACLD (transient elastography ≥ 10 kPa) submitted to two-dimensional SWE (2D-SWE) (GE-LOGIQ-S8) and/or point SWE (p-SWE) (ElastPQ) who had a gastrointestinal endoscopy within 24 months. HRV definition was a large size and presence of red wale marks or sequelae from previous treatment. Optimal thresholds of SWE systems for HRV were identified. The proportion of spared gastrointestinal endoscopies and missing HRV considering a favorable SWE Baveno VI criteria were assessed.

Results
Eighty patients [36% male, median age = 63 (interquartile range, 57–69) years] were included. The prevalence of HRV was 34% (n = 27/80). The optimal thresholds to predict HRV were 10 kPa and 12 kPa for 2D-SWE and p-SWE, respectively. A favorable 2D-SWE Baveno VI criteria (LSM < 10 kPa and platelets count > 150 × 109/mm3) avoided 19% of gastrointestinal endoscopies without missing HRVs. A favorable p-SWE Baveno VI criteria (LSM < 12 kPa and platelets count > 150 × 109/mm3) spared 20% of gastrointestinal endoscopy without missing HRVs. Using a lower threshold of platelet count (<110 × 109/mm3, expanded Baveno VI), 2D-SWE (<10 kPa) avoided 33% of gastrointestinal endoscopy with 8% of missing HRVs, while p-SWE (<12 kPa) avoided 36% of gastrointestinal endoscopy with 5% of missing HRVs.

Conclusion
LSM by p-SWE or 2D-SWE combined with platelet count (Baveno VI criteria) can spare a considerable number of gastrointestinal endoscopies missing a negligible proportion of HRV.
Relationship between lipid profiles and reduced handgrip strength (dynapenia) in hospitalized patients with cirrhosis
Authors: Cui Binxin , Hui Yangyang , Sun Chao 
Published: March 2023

Background
Dynapenia embraces clinical significance and predictive value separated from skeletal muscle loss among cirrhosis. Moreover, alterations in lipid levels may impact muscle function. It has yet to elucidate the relationship between lipid profiles and muscle strength weakness. We sought to explore which lipid metabolism indicator could be useful to identify patients with dynapenia in daily practice.

Methods
A retrospective observational cohort study enrolling 262 cirrhotic patients. Analysis of the receiver operating characteristic (ROC) curve was performed to determine the discriminatory cutoff for dynapenia. Multivariate logistic regression was conducted to assess the association between total cholesterol (TC) and dynapenia. Also, we established a model based on the classification and regression tree method.

Results
ROC implicated a cutoff of TC ≤ 3.37 mmol/L to identify dynapenia. Patients with TC ≤ 3.37 mmol/L showed significantly lower handgrip strength (HGS; 20.0 vs. 24.7 kg, P = 0.003), lower hemoglobin, lower platelet, lower white blood cell count, lower sodium and higher prothrombin-international normalized ratio. A positive correlation was found between TC and HGS values (r = 0.1860, P = 0.003). TC remained a significant association with dynapenia after controlling for variables including age, sex, BMI, and the presence of ascites. The decision tree incorporating TC, BMI, and age had a sensitivity of 71.4%, specificity of 64.9%, and an area under ROC of 0.681.

Conclusion
TC ≤ 3.37 mmol/L was significantly associated with the presence of dynapenia. Assessing TC may be helpful for identifying dynapenic patients with cirrhosis in the health care or hospital setting.
Postoperative Urinary Retention
Authors: McDermott Colleen D. , Tunitsky-Bitton Elena , Dueñas-Garcia Omar F. , Willis-Gray Marcella G. , Cadish Lauren A. , Edenfield Autumn , Wang Rui , Meriwether Kate , Mueller Elizabeth R. 
Published: March 2023

AbstractThis clinical consensus statement on the management of postoperative (<6 weeks) urinary retention (POUR) reflects statements drafted by content experts from the American Urogynecologic Society’s POUR writing group. The writing group used a modified Delphi process to evaluate statements developed from a structured literature search and assessed for consensus. After the definition of POUR was established, a total of 37 statements were assessed in the following 6 categories: (1) incidence of POUR, (2) medications, (3) patient factors, (4) surgical factors, (5) urodynamic testing, and (6) voiding trials. Of the 37 original statements, 34 reached consensus and 3 were omitted.