bluuebunny/crossref_metadata_2025_split huggingface dataset:
Programmatic Effectiveness of a Pediatric Typhoid Conjugate Vaccine Campaign in Navi Mumbai, India
Authors: Hoffman Seth A , LeBoa Christopher , Date Kashmira , Haldar Pradeep , Harvey Pauline , Shimpi Rahul , An Qian , Zhang Chenhua , Jayaprasad Niniya , Horng Lily , Fagerli Kirsten , Borhade Priyanka , Daruwalla Savita , Dharmapalan Dhanya , Gavhane Jeetendra , Joshi Shrikrishna , Rai Rajesh , Rathod Varsha , Shetty Keertana , Warrier Divyalatha S , Yadav Shalini , Chakraborty Debjit , Bahl Sunil , Katkar Arun , Kunwar Abhishek , Yewale Vijay , Andrews Jason R , Bhatnagar Pankaj , Dutta Shanta , Luby Stephen P 
Published: March 2023

Abstract

Background
The World Health Organization recommends vaccines for prevention and control of typhoid fever, especially where antimicrobial-resistant typhoid circulates. In 2018, the Navi Mumbai Municipal Corporation (NMMC) implemented a typhoid conjugate vaccine (TCV) campaign. The campaign targeted all children aged 9 months through 14 years within NMMC boundaries (approximately 320 000 children) over 2 vaccination phases. The phase 1 campaign occurred from 14 July 2018 through 25 August 2018 (71% coverage, approximately 113 420 children). We evaluated the phase 1 campaign's programmatic effectiveness in reducing typhoid cases at the community level.

Methods
We established prospective, blood culture–based surveillance at 6 hospitals in Navi Mumbai and offered blood cultures to children who presented with fever ≥3 days. We used a cluster-randomized (by administrative boundary) test-negative design to estimate the effectiveness of the vaccination campaign on pediatric typhoid cases. We matched test-positive, culture-confirmed typhoid cases with up to 3 test-negative, culture-negative controls by age and date of blood culture and assessed community vaccine campaign phase as an exposure using conditional logistic regression.

Results
Between 1 September 2018 and 31 March 2021, we identified 81 typhoid cases and matched these with 238 controls. Cases were 0.44 times as likely to live in vaccine campaign communities (programmatic effectiveness, 56%; 95% confidence interval [CI], 25% to 74%; P = .002). Cases aged ≥5 years were 0.37 times as likely (95% CI, .19 to .70; P = .002) and cases during the first year of surveillance were 0.30 times as likely (95% CI, .14 to .64; P = .002) to live in vaccine campaign communities.

Conclusions
Our findings support the use of TCV mass vaccination campaigns as effective population-based tools to combat typhoid fever.
Aerobic high-intensity interval exercise training in patients with angina and no obstructive coronary artery disease: feasibility and physiological effects
Authors: Larsen Alf Inge , Sæland Charlotte , Vegsundvåg Johnny , Skadberg Mette Storebø , Nilsen Jorunn , Butt Noreen , Ushakova Anastasia , Valborgland Torstein , Munk Peter Scott , Isaksen Kjetil 
Published: March 2023

Abstract

Aims
Patients with chest pain and normal coronary angiogram [angina with normal coronary arteries (ANOCA)] constitute a therapeutic problem with considerable functional limitation and reduced quality of life. The aims of the current pilot study were to (i) explore if a structured aerobic high-intensity interval training (HIT) program for 12 weeks was feasible in patients with ANOCA, and (ii) to assess mechanisms related to symptoms in this population.

Methods and results
Sixteen patients with ANOCA underwent a 3-month aerobic HIT program with one-to-one monitored exercise sessions on treadmill in a 4 min × 4 manner, three times a week. Four patients served as controls. Coronary flow velocity reserve (CFVR) transthoracic Doppler, flow-mediated vasodilation (FMD) and VO2max was measured at baseline and after 12 weeks. The average attendance to training sessions was 82.3% ± 10.1 (56–94). CFVR in the training group increased from 2.50 ± 0.48 to 3.04 ± 0.71 (P &lt; 0.001) whereas FMD increased from 4.19 ± 2.42% to 8.28 ± 2.85% (P &lt; 0.001). Improvement in CFVR correlated with the relative improvement in FMD (R = 0.45, P = 0.047). This was associated with an increase in VO2max from 28.75 ± 6.51 mL/kg/min to 31.93 ± 6.46 mL/kg/min (P &lt; 0.001).

Conclusion
A 3-month program of monitored HIT was feasible, with high adherence resulting in improved functional capacity in patients with ANOCA. CFVR improved and this improvement was associated with improved FMD.

ClinicalTrials.gov Identifier
NCT02905630
Anthropometric measures and adverse outcomes in heart failure with reduced ejection fraction: revisiting the obesity paradox
Authors: Butt Jawad H , Petrie Mark C , Jhund Pardeep S , Sattar Naveed , Desai Akshay S , Køber Lars , Rouleau Jean L , Swedberg Karl , Zile Michael R , Solomon Scott D , Packer Milton , McMurray John J V 
Published: March 2023

AbstractAimsAlthough body mass index (BMI) is the most commonly used anthropometric measure, newer indices such as the waist-to-height ratio, better reflect the location and amount of ectopic fat, as well as the weight of the skeleton, and may be more useful.Methods and resultsThe prognostic value of several newer anthropometric indices was compared with that of BMI in patients with heart failure (HF) and reduced ejection fraction (HFrEF) enrolled in prospective comparison of ARNI with ACEI to determine impact on global mortality and morbidity in heart failure. The primary outcome was HF hospitalization or cardiovascular death. The association between anthropometric indices and outcomes were comprehensively adjusted for other prognostic variables, including natriuretic peptides. An ‘obesity-survival paradox’ related to lower mortality risk in those with BMI ≥25 kg/m2 (compared with normal weight) was identified but this was eliminated by adjustment for other prognostic variables. This paradox was less evident for waist-to-height ratio (as an exemplar of indices not incorporating weight) and eliminated by adjustment: the adjusted hazard ratio (aHR) for all-cause mortality, for quintile 5 vs. quintile 1, was 1.10 [95% confidence interval (CI) 0.87–1.39]. However, both BMI and waist-to-height ratio showed that greater adiposity was associated with a higher risk of the primary outcome and HF hospitalization; this was more evident for waist-to-height ratio and persisted after adjustment e.g. the aHR for HF hospitalization for quintile 5 vs. quintile 1 of waist-to-height ratio was 1.39 (95% CI 1.06–1.81).ConclusionIn patients with HFrEF, alternative anthropometric measurements showed no evidence for an ‘obesity-survival paradox’. Newer indices that do not incorporate weight showed that greater adiposity was clearly associated with a higher risk of HF hospitalization.
Temporal trends in low-dose aspirin therapy for primary prevention of cardiovascular disease in European adults with and without diabetes
Authors: Kristensen Anna Meta Dyrvig , Pareek Manan , Kragholm Kristian Hay , Torp-Pedersen Christian , McEvoy John William , Prescott Eva Bossano 
Published: March 2023

Abstract

Aims
Aspirin therapy for primary prevention of cardiovascular disease (CVD) is controversial, and guideline recommendations have changed throughout the last decades. We report temporal trends in primary prevention aspirin use among persons with and without diabetes and describe characteristics of incident aspirin users.

Methods and results
Using Danish nationwide registries, we identified incident and prevalent aspirin users in a population of subjects ≥40 years without CVD eligible for primary preventive aspirin therapy from 2000 through 2020. Temporal trends in aspirin users with and without diabetes were assessed, as were CVD risk factors among incident users. A total of 522 680 individuals started aspirin therapy during the study period. The number of incident users peaked in 2002 (39 803 individuals, 1.78% of the eligible population) and was the lowest in 2019 (11 898 individuals, 0.49%), with similar trends for subjects with and without diabetes. The percentage of incident users with no CVD risk factors [diabetes, hypertension, hypercholesterolemia, or chronic obstructive pulmonary disease (a proxy for smoking)] decreased from 53.9% in 2000 to 30.9% in 2020. The temporal trends in prevalent aspirin users followed a unimodal curve, peaked at 7.7% in 2008, and was 3.3% in 2020. For subjects with diabetes, the peak was observed in 2009 at 38.5% decreasing to 17.1% in 2020.

Conclusion
Aspirin therapy for primary prevention of CVD has decreased over the last two decades. However, the drug remained used in individuals with and without diabetes, and a large proportion of individuals started on aspirin therapy had no CVD risk factors.
Assessing Carbon Abatement Costs Considering Forest Carbon Sequestration and Carbon Offset Mechanism: Evidence from Taiwan
Authors: Liu Wan-Yu , Lu Yi-Hsin , Lin Chun-Cheng 
Published: March 2023

Abstract
Based on the Greenhouse Gas Reduction and Management Act passed in 2015 and the carbon neutral target in 2050, Taiwan will most likely follow international trends by imposing carbon taxes and establishing carbon offset markets. The positive and negative effects of carbon taxes and carbon offset markets on the economy and the environment merit further investigation. Accordingly, this study adopted a carbon emission reduction (CER) cost prediction model to assess the carbon abatement costs under three scenarios: (1) a carbon offset market exists, and forest carbon sequestration can be used as carbon offsets; (2) a carbon offset market exists, but forest carbon sequestration cannot be used as carbon offsets; and (3) a carbon offset market does not exist. Forests in Taipei (with low carbon emissions) and Kaohsiung (with high carbon emissions) were selected as research sites to explore the benefits of carbon emissions trading and forest carbon sequestration. The results show that CER costs are the lowest in scenario 1 and are the highest in scenario 3. The CER costs of Kaohsiung are higher than those of Taipei. The higher the carbon price, the greater the difference in CER costs between the two cities.
Study Implications: The objective of this study was to identify the optimal policy for Taiwan to effectively slow climate change. This study showed that the opening of carbon offset markets and the use of forest carbon sequestration as carbon offsets may prompt regions to increase their forest stock to lower their emission reduction costs. However, achieving 2050 carbon neutral target by solely using forest carbon sequestration is not sufficient in Taiwan.
Strong-State Restraint as a Legitimation Strategy: Evidence from the South China Sea
Authors: Huang Chin-Hao 
Published: March 2023

AbstractThis article argues that strong-state restraint is more likely to occur when lesser powers articulate their security preferences with a strong consensus. Why? Adherence to the consensus clarifies the dominant state's cooperative intentions, institutionalizes defensive military postures to mitigate security dilemma, and provides the concomitant benefit of recognition as a credible leader. If external validation matters in identity formation, then the acceptance of strong group consensus becomes an incentivizing legitimation strategy. This observation is evident in the interactions and authority relations between China and the Association of Southeast Asian Nations (ASEAN) in the South China Sea. ASEAN members’ ability to develop security norms aimed at defusing tension shows that they are not as vulnerable as many believe. The finding draws on empirical evidence to show how small states induce change in a large power's behavior, and thus a positive theoretical advance with a testable argument about the causes for strong-state restraint.
Hypoxia Resistance Is an Inherent Phenotype of the Mouse Flexor Digitorum Brevis Skeletal Muscle
Authors: Amorese Adam J , Minchew Everett C , Tarpey Michael D , Readyoff Andrew T , Williamson Nicholas C , Schmidt Cameron A , McMillin Shawna L , Goldberg Emma J , Terwilliger Zoe S , Spangenburg Quincy A , Witczak Carol A , Brault Jeffrey J , Abel E Dale , McClung Joseph M , Fisher-Wellman Kelsey H , Spangenburg Espen E 
Published: March 2023

Abstract
The various functions of skeletal muscle (movement, respiration, thermogenesis, etc.) require the presence of oxygen (O2). Inadequate O2 bioavailability (ie, hypoxia) is detrimental to muscle function and, in chronic cases, can result in muscle wasting. Current therapeutic interventions have proven largely ineffective to rescue skeletal muscle from hypoxic damage. However, our lab has identified a mammalian skeletal muscle that maintains proper physiological function in an environment depleted of O2. Using mouse models of in vivo hindlimb ischemia and ex vivo anoxia exposure, we observed the preservation of force production in the flexor digitorum brevis (FDB), while in contrast the extensor digitorum longus (EDL) and soleus muscles suffered loss of force output. Unlike other muscles, we found that the FDB phenotype is not dependent on mitochondria, which partially explains the hypoxia resistance. Muscle proteomes were interrogated using a discovery-based approach, which identified significantly greater expression of the transmembrane glucose transporter GLUT1 in the FDB as compared to the EDL and soleus. Through loss-and-gain-of-function approaches, we determined that GLUT1 is necessary for the FDB to survive hypoxia, but overexpression of GLUT1 was insufficient to rescue other skeletal muscles from hypoxic damage. Collectively, the data demonstrate that the FDB is uniquely resistant to hypoxic insults. Defining the mechanisms that explain the phenotype may provide insight towards developing approaches for preventing hypoxia-induced tissue damage.
Genomic selection for genotype performance and environmental stability in Coffea canephora
Authors: Adunola Paul , Ferrão Maria Amélia G , Ferrão Romário G , da Fonseca Aymbire F A , Volpi Paulo S , Comério Marcone , Verdin Filho Abraão C , Munoz Patricio R , Ferrão Luís Felipe V 
Published: March 2023

Abstract
Coffee is one of the most important beverages and trade products in the world. Among the multiple research initiatives focused on coffee sustainability, plant breeding provides the best means to increase phenotypic performance and release cultivars that could meet market demands. Since coffee is well adapted to a diversity of tropical environments, an important question for those confronting the problem of evaluating phenotypic performance is the relevance of genotype-by-environment interaction. As a perennial crop with a long juvenile phase, coffee is subjected to significant temporal and spatial variations. Such facts not only hinder the selection of promising materials but also cause a majority of complaints among growers. In this study, we hypothesized that trait stability in coffee is genetically controlled and therefore is predictable using molecular information. To test it, we used genome-based methods to predict stability metrics computed with the primary goal of selecting coffee genotypes that combine high phenotypic performance and stability for target environments. Using 2 populations of Coffea canephora, evaluated across multiple years and locations, our contribution is 3-fold: (1) first, we demonstrated that the number of harvest evaluations may be reduced leading to accelerated implementation of molecular breeding; (2) we showed that stability metrics are predictable; and finally, (3) both stable and high-performance genotypes can be simultaneously predicted and selected. While this research was carried out on representative environments for coffee production with substantial crossover in genotypic ranking, we anticipate that genomic prediction can be an efficient tool to select coffee genotypes that combine high performance and stability across years and the target locations here evaluated.
Loss- and gain-of-function analyses reveal the essential role of Cyp19a1 in ovarian determination of the red-eared slider turtle
Authors: Shen Jiadong , Sun Wei , Wu Kaiyue , Zhuang Tianyi , Lei Jiandong , Ma Qinglu , Xiao Ling , Ge Chutian 
Published: March 2023

Abstract
Estrogen signaling exerts a decisive role in female sex determination and differentiation in chicken and fish. Aromatase encoded by Cyp19a1 is the key enzyme that catalyzes the conversion of androgen to estrogen. Correlative analyses implicate the potential involvement of aromatase in reptilian sexual development, however, the direct genetic evidence is lacking. Herein, we found that Cyp19a1 exhibited temperature-dependent sexually dimorphic expression, and located in the medullary somatic cells in early female embryos of the red-eared slider turtle (Trachemys scripta elegans), before the gonad is distinct. To determine the functional role of Cyp19a1 in turtle ovarian determination, we established loss- and gain-of-function models through in ovo lentivirus-mediated genetic manipulation. At female-producing temperature, inhibition of aromatase or knockdown of Cyp19a1 in turtle embryos resulted in female-to-male sex reversal, with the formation of a testis-like structure and a male distribution pattern of germ cells, as well as ectopic expression of male-specific markers (SOX9 and AMH) and disappearance of ovarian regulator FOXL2. On the contrary, overexpression of Cyp19a1 at male-producing temperature led to male-to-female sex reversal. In conclusion, our results suggest that Cyp19a1 is both necessary and sufficient for ovarian determination in the red-eared slider turtle, establishing causality and a direct genetic link between aromatase and reptilian sex determination and differentiation.
Matching-Adjusted Indirect Comparisons of Filgotinib vs Vedolizumab, Tofacitinib, and Ustekinumab for Moderately to Severely Active Ulcerative Colitis
Authors: Lu Xiaoyan , Zhou Zheng-Yi , Xin Yiqiao , Wang Min-Jung , Gray Emma , Jairath Vipul , Lindsay James Oliver 
Published: March 2023

Abstract

Background
Where head-to-head trials are lacking, indirect comparative effectiveness can aid treatment decisions. We conducted matching-adjusted indirect comparisons of clinical outcomes with filgotinib vs recently approved comparators (vedolizumab, tofacitinib, ustekinumab) in patients with moderately to severely active ulcerative colitis (UC).

Methods
Individual patient data from the SELECTION trial (NCT02914522) for filgotinib 200 mg were weighted to match average baseline characteristics of active treatment and placebo arms in comparator trials. Efficacy outcomes were compared for biologic-naive and biologic-experienced subgroups in induction and maintenance populations, if data were available. Safety and health-related quality of life outcomes were compared in the overall maintenance population.

Results
Filgotinib had a similar effect on efficacy outcomes compared with tofacitinib, ustekinumab, and subcutaneous vedolizumab in both the induction and maintenance populations. Filgotinib showed improved clinical response vs intravenous (IV) vedolizumab (odds ratio, 2.4; 95% confidence interval [CI], 1.0 to 5.5; P &lt; .05) among the biologic-experienced induction population, and improved corticosteroid-free clinical remission (odds ratio, 15.2; 95% CI, 1.6 to 139.9; P &lt; .05) among the biologic-naive maintenance population. Improved efficacy outcomes were reported with filgotinib compared with ustekinumab among the maintenance population. Higher estimates of serious adverse events were reported for filgotinib compared with vedolizumab IV 300 mg and tofacitinib 5 mg; however, imbalances were noted in their placebo groups. Health-related quality of life outcomes were similar between filgotinib and comparators.

Conclusions
Matching-adjusted indirect comparison results suggest superiority of filgotinib 200 mg over vedolizumab IV in terms of clinical response and corticosteroid-free clinical remission in certain patient populations, noting small sample sizes and wide CIs, which may aid the selection of advanced therapies for moderately to severely active UC. A potential increased risk of serious adverse events was reported for filgotinib 200 mg vs vedolizumab IV and tofacitinib 5 mg, but findings should be interpreted with caution owing to underlying imbalances observed between the placebo groups of SELECTION and comparator trials.
Epidemiology of Inflammatory Bowel Disease in a Cohort of US Black Women
Authors: Anyane-Yeboa Adjoa , Buadu Maame Araba E , Khalili Hamed , Cozier Yvette C 
Published: March 2023

Abstract

Background and Aims
Inflammatory bowel disease (IBD), including ulcerative colitis and Crohn’s disease, are inflammatory diseases of the gastrointestinal tract. The incidence of IBD is increasing in minority populations; however, little is known about the epidemiology and disease characteristics of IBD in Black women.

Methods
Our study population included participants in the Black Women’s Health Study. Diagnosis of IBD was self-reported through the biennial questionnaires starting at baseline in 1995. We estimated the incidence of IBD according to age and geographic region. A follow-up supplementary questionnaire was also sent to a subset of participants who reported diagnosis of IBD to evaluate the accuracy of self-reported diagnosis and to assess disease characteristics.

Results
Through December 31, 2021, a total of 609 cases of IBD were reported, of which 142 were prevalent at baseline (prevalence, 0.24%), and 467 were incident (crude incidence rate, 33.2/100 000 person-years). The incidence of IBD was highest in the younger than 30 years age group and similar across geographic region. Among the participants who responded to the supplementary questionnaire, 57.1% had confirmed diagnosis of IBD.

Conclusions
In a large prospective cohort of US Black women, we found that the incidence of IBD was similar to previously published estimates in US White women. Future studies should focus on identifying risk factors for IBD in Black individuals in the United States.
Cracking the challenges of incentivizing avoidance of unwanted catch
Authors: Pol Mike , Maravelias Christos D 
Published: March 2023

AbstractEffective tools, techniques, and strategies to improve commercial fish catches frequently seem to be overlooked or unused. The mixed success of two major approaches to avoiding or reducing unwanted catches, voluntary or mandatory use of more selective gear, and spatiotemporal shifts of effort based on resource distributions, inspired the call for this themed article set (TS). This TS sought to promote deeper consideration of these outcomes by encouraging research to investigate what is required to make alternative, more selective gear, and spatiotemporal avoidance more attractive to fishers. Of the eighteen articles in the TS, seven investigated the behaviour of fishers and applied existing or novel models to deepen understanding of motivations and incentives to change; little overlap among theories was found, and more and deeper consideration of this topic is needed. Five considered aspects of spatiotemporal avoidance; five described technical or other measures. Creative ideas on these topics continue to arise, but understanding of the motivations of fishers to initiate and maintain cooperative behaviours is still rudimentary. One used good, bad, and ugly experiences with policy implementers to promote governance research to crack open the understanding of interactions between policy implementers and policy advisors, and to identify changes needed to facilitate bottom-up initiatives.