bluuebunny/crossref_metadata_2025_split huggingface dataset:
Knowledge mapping concerning applications of nanocomposite hydrogels for drug delivery: A bibliometric and visualized study (2003–2022)
Authors: Wang Hao , Fu Hongxun , Fu Yefan , Jiang Lin , Wang Liye , Tong Haibin , Xie Zuoxu , Huang Peng , Sun Meiyan 
Published: January 2023

Background: Nanocomposite Hydrogels (NHs) are 3D molecular networks formed by physically or covalently crosslinking polymer with nanoparticles or nanostructures, which are particularly suitable for serving as carriers for drug delivery systems. Many articles pertaining to the applications of Nanocomposite Hydrogels for drug delivery have been published, however, the use of bibliometric and visualized analysis in this area remains unstudied. The purpose of this bibliometric study intended to comprehensively analyze the knowledge domain, research hotspots and frontiers associated with the applications of Nanocomposite Hydrogels for drug delivery.Methods: We identified and retrieved the publications concerning the applications of NHs for drug delivery between 2003 and 2022 from Web of Science Core Collection Bibliometric and visualized analysis was utilized in this investigative study.Results: 631 articles meeting the inclusion criteria were identified and retrieved from WoSCC. Among those, 2,233 authors worldwide contributed in the studies, accompanied by an average annual article increase of 24.67%. The articles were co-authored by 764 institutions from 52 countries/regions, and China published the most, followed by Iran and the United States. Five institutions published more than 40 papers, namely Univ Tabriz (n = 79), Tabriz Univ Med Sci (n = 70), Islamic Azad Univ (n = 49), Payame Noor Univ (n = 42) and Texas A&amp;M Univ (n = 41). The articles were published in 198 journals, among which the International Journal of Biological Macromolecules (n = 53) published the most articles, followed by Carbohydrate Polymers (n = 24) and ACS Applied Materials and Interfaces (n = 22). The top three journals most locally cited were Carbohydrate Polymers, Biomaterials and Advanced materials. The most productive author was Namazi H (29 articles), followed by Bardajee G (15 articles) and Zhang J (11 articles) and the researchers who worked closely with other ones usually published more papers. “Doxorubicin,” “antibacterial” and “responsive hydrogels” represent the current research hotspots in this field and “cancer therapy” was a rising research topic in recent years. “(cancer) therapeutics” and “bioadhesive” represent the current research frontiers.Conclusion: This bibliometric and visualized analysis offered an investigative study and comprehensive understanding of publications regarding the applications of Nanocomposite Hydrogels for drug delivery from 2003 to 2022. The outcome of this study would provide insights for researchers in the field of Nanocomposite Hydrogels applications for drug delivery.
Potential value of saline-induced Pd/Pa ratio in patients with coronary artery stenosis
Authors: Kiriyama Hiroyuki , Kiyosue Arihiro , Minatsuki Shun , Kawahara Takuya , Katsushika Susumu , Kamon Tatsuya , Hirose Kazutoshi , Shinohara Hiroki , Miura Mizuki , Saito Akihito , Kikuchi Hironobu , Kodera Satoshi , Hatano Masaru , Ando Jiro , Myojo Masahiro , Itoh Nobuhiko , Yamamoto Keisuke , Ikenouchi Hiroshi , Takeda Norifumi , Komuro Issei 
Published: January 2023

BackgroundFractional flow reserve (FFR) is the current gold standard for identifying myocardial ischemia in individuals with coronary artery stenosis. However, FFR is not penetrated as much worldwide due to time consumption, costs associated with adenosine, FFR-related discomfort, and complications. Resting physiological indexes may be widely accepted alternatives to FFR, while the discrepancies with FFR were found in up to 20% of lesions. The saline-induced Pd/Pa ratio (SPR) is a new simplified option for evaluating coronary stenosis. However, the clinical implication of SPR remains unclear.ObjectivesIn the present study, we aimed to compare the accuracies of SPR and resting full-cycle ratio (RFR) and to investigate the incremental value of SPR in clinical practice.MethodsIn this multicenter prospective study, 112 coronary lesions (105 patients) were evaluated by SPR, RFR, and FFR.ResultsThe overall median age was 71 years, and 84.8% were men. SPR was correlated more strongly with FFR than with RFR (r = 0.874 vs. 0.713, respectively; p &lt; 0.001). Using FFR &lt; 0.80 as the reference standard variable, the area under the receiver-operating characteristic (ROC) curve for SPR was superior to that of RFR (0.932 vs. 0.840, respectively; p = 0.009).ConclusionSaline-induced Pd/Pa ratio predicted FFR more accurately than RFR. SPR could be an alternative method for evaluating coronary artery stenosis and further investigation including elucidation of the mechanism of SPR is needed (225 words).
lncRNA LOC100911717-targeting GAP43-mediated sympathetic remodeling after myocardial infarction in rats
Authors: Li Pingjiang , Wang Kang , Yin Jie , Qi Lei , Hu Hesheng , Yang Peijin , Shi Yugen , Li Yan , Feng Meng , Lyu Hangji , Ge Weili , Li Xiaolu , Yan Suhua 
Published: January 2023

ObjectiveSympathetic remodeling after myocardial infarction (MI) is the primary cause of ventricular arrhythmias (VAs), leading to sudden cardiac death (SCD). M1-type macrophages are closely associated with inflammation and sympathetic remodeling after MI. Long noncoding RNAs (lncRNAs) are critical for the regulation of cardiovascular disease development. Therefore, this study aimed to identify the lncRNAs involved in MI and reveal a possible regulatory mechanism.Methods and resultsM0- and M1-type macrophages were selected for sequencing and screened for differentially expressed lncRNAs. The data revealed that lncRNA LOC100911717 was upregulated in M1-type macrophages but not in M0-type macrophages. In addition, the lncRNA LOC100911717 was upregulated in heart tissues after MI. Furthermore, an RNA pull-down assay revealed that lncRNA LOC100911717 could interact with growth-associated protein 43 (GAP43). Essentially, immunofluorescence assays and programmed electrical stimulation demonstrated that GAP43 expression was suppressed and VA incidence was reduced after lncRNA LOC100911717 knockdown in rat hearts using an adeno-associated virus.ConclusionsWe observed a novel relationship between lncRNA LOC100911717 and GAP43. After MI, lncRNA LOC100911717 was upregulated and GAP43 expression was enhanced, thus increasing the extent of sympathetic remodeling and the frequency of VA events. Consequently, silencing lncRNA LOC100911717 could reduce sympathetic remodeling and VAs.
The feasibility and safety of combining atrial septal defect/patent foramen ovale and left atrial appendage closure: A systematic review and meta-analysis
Authors: Song Yi , Xing Hang , Koch Peter David , Li Xiaofei , Zhang Yan 
Published: January 2023

IntroductionAtrial Septal Defect/Patent Foramen Ovale (ASD/PFO) occlusion is performed to prevent paradoxical embolism and reduce the risk of recurrent ischemic stroke. Left atrial appendage (LAA) closure is used as an alternative to medical therapy of non-valvular atrial fibrillation for prevention of stroke. Multiple studies have examined performing LAA and ASD/PFO occlusion. However, the feasibility and safety of combined occlusion of the left atrial appendage and ASD/PFO are not clear, furthermore, these studies are limited by their small sample sizes and retrospective analysis. In this study, we aimed to systematically review and meta-analyze the feasibility and safety of combining left atrial appendage and ASD/PFO closure.MethodsPubMed, Web of Science, CNKI, Cochrane Library, Embase, and WanFang database were searched up to April 2022 to identify peer-reviewed human studies on assessing the feasibility, safety, and efficacy of combining left atrial appendage and ASD/PFO closure. The primary outcome was calculated: procedural feasibility outcome and procedural safety outcome.ResultsA total of 10 articles, including 340 patients from multiple countries, were included in the analysis. The principal findings of our study are: compared with single LAA closure, (i) combining PFO/ASD occlusion and LAA closure had similar procedural success proportion (98.43%, 95% CI: 96.67–100.00%), (ii) similar safety event incidences developed (1.67%, 95% CI: 0.24–3.92%), subgroup analyzed safety event incidences in death was 0.00 (95% CI: 0.00–0.33%), cardiac tamponade was 0.87% (95% CI: 0.00–2.77%), device embolization was 0.00 (95% CI: 0.00–0.60%), major bleeding was 0.00 (95% CI: 0.00–0.33%), stroke was 0.00 (95% CI: 0.00–0.02%).ConclusionAlthough this systematic review and meta-analysis demonstrate the technical feasibility and safety of combining closure of PFO/ASD and LAA, further studies of sufficient sample size, long-term follow-up, and rigor endpoint criteria are yet needed to fully evaluate this combination procedure for its role in clinical outcomes.
Prognostic value of interleukin-33, sST2, myeloperoxidase, and matrix metalloproteinase-9 in acute aortic dissection
Authors: Jia Yu , Li Dongze , Yu Jing , Jiang Wenli , Liu Yi , Li Fanghui , Li Wentao , Zeng Rui , Liao Xiaoyang , Wan Zhi 
Published: January 2023

Background and purposeAcute aortic dissection (AAD) is a life-threatening cardiovascular emergency. Both neutrophil granzyme and interleukin (IL)-33/ST2 systems have proven to be effective diagnostic markers for AAD. This study aimed to investigate the relationship between plasma IL-33, soluble suppression of tumorigenesis-2 (sST2), myeloperoxidase (MPO), and matrix metalloproteinase (MMP)-9 levels at admission and all-cause mortality in patients with AAD.MethodsA total of 155 patients with AAD were enrolled from the Prospective Evaluation of Acute Chest Pain (PEACP) study. Plasma concentrations of IL-33, sST2, and MMP-9 were measured using an enzyme-linked immunosorbent assay, and MPO was detected using a chemiluminescence immunoassay. Aortic anatomical parameters were measured using CT radiography. The primary endpoint was all-cause mortality rate.ResultsThe median age of the patients was 55 years, and 96 (61.9%) were diagnosed with type A-AAD. After adjusting for confounding factors, the highest tertiles of IL-33, sST2, MPO, and MMP-9 had hazard risks of 0.870 (95% CI: 0.412–1.836, P = 0.714), 3.769 (95% CI: 1.504–9.446, P = 0.005), 4.689 (95% CI: 1.985–11.076, P &lt; 0.001), and 4.748 (95% CI: 1.763–12.784, P = 0.002), respectively, compared to the lowest tertile. Pearson’s correlation analysis revealed a significant correlation between these markers (P &lt; 0.001). Moreover, sST2, MPO, and MMP-9 levels had a significant positive correlation with aortic diameter and pseudolumen area (P &lt; 0.001).ConclusionThe biomarkers sST2, MPO, and MMP-9 were independently associated with mortality in patients with AAD. The significant correlation between these biomarkers suggests a pathogenic role for the IL-33/ST2/neutrophil granzyme system in patients with AAD.
Current status and technology development in implementing low carbon emission energy on underground coal gasification (UCG)
Authors: Takyi Shadrack Adjei , Zhang Yindi , Si Mengting , Zeng Fanjin , Li Yingnan , Tontiwachwuthikul Paitoon 
Published: January 2023

Although coal mining has played a substantial role in world’s development as a critical fuel source for at least 25 years, its value is partly offset by the massive environmental issues it presents during combustion. The shift to a net-zero CO2 emission will open unique possibilities for new coal technological models in which progressive studies and policies, development, and modernization will play a significant role. Therefore, a collection of technologies has been proposed, one of which is cost-effective is the Underground Coal Gasification (UCG) coupled with carbon capture storage (CCS) and utilization technology (CCU) UCG-CCS/CCU. This paper reviews the current status and technology development in implementing low carbon emission energy on underground coal gasification. The study, therefore, leads to discussing the modern stage of underground coal gasification and carbon capture storage development, recent pilot operations, and current developments of the growing market. At the same time, it provides a reference for underground coal gasification combined with CCUS technology.
Erosion-reducing potential of Salix psammophila roots in the water–wind crisscrossed erosion region of the Chinese Loess Plateau: A simulated investigation
Authors: Zhang Zheng , Yu Weijie , Li Qiang , Sun Hui , Feng Zhidao , Zou Jiatong 
Published: January 2023

Laboratory-simulated experiments under a one-way wind erosion–rain erosion sequence were conducted to investigate the effect of S. psammophila roots on wind and water erosion processes and quantify its erosion-reducing potential. With the collected soil of sandy loam and planted shrub of S. psammophila, 16 soil boxes including bare and root-permeated soils were arranged in March 2017 and conducted in August 2017. With the wind speeds of 11 and 14 m s−1 and rainfall intensities of 60 and 100 mm h−1, two levels of interaction (11 m s−1 × 60 mm h−1 and 14 m s−1 × 100 mm h−1) were designed. The particle-size composition and sediment transport flux were examined in the former wind tunnel experiments, and the runoff hydrodynamic parameters and runoff and water erosion rates were determined in the following rainfall tests. The sediment reduction effect by roots (%) was used to quantify the erosion-reducing potential of roots. The results demonstrated that in the former wind tunnel experiments, compared with the bare soils, the root-permeated soils showed a slight coarsening of surface soil and had 18.03% and 35.71% less sediment transport flux at wind speeds of 11 and 14 m s−1, respectively. In the following rainfall tests, S. psammophila roots weakened the hydrodynamic intensity of overland flow and decreased runoff and water erosion rates by 13.34%, 30.70% and 4.44%, 43.72% at rainfall intensities of 60 and 100 mm h−1, respectively. Different from the water erosion process of bare soils, which showed an increased fluctuated trend, the root-permeated soils presented a steady increase in the early stage of rainfall and then a decrease-stable trend at the mid and end of rainfall. In the wind tunnel–rainfall experiments, the sediment reduction effect by Salix psammophila roots showed 24.37% and 39.72% at levels of 11 m s−1 × 60 mm h−1 and 14 m s−1 × 100 mm h−1, respectively. This kind of study may provide more insights into understanding ecological impacts of sandy vegetation construction on the water–wind crisscrossed erosion region of the Chinese Loess Plateau and also sandy land.
Effects of soil grain size and solution chemistry on the transport of biochar nanoparticles
Authors: Zhang Wenke , Meng Jun , Huang Yuwei , Sarkar Binoy , Singh Bhupinder Pal , Zhou Xuanwei , Gao Jian , Teng Yunpeng , Wang Hailong , Chen Wenfu 
Published: January 2023

Biochar nanoparticles (BC-NP) have attracted significant attention because of their unique environmental behavior, some of which could potentially limit large-scale field application of biochar. Accurate prediction of the fate and transportability of BC-NP in soil matrix is the key to evaluating their environmental influence. This study investigated the effects of soil grain size and environmentally relevant solution chemistry, such as ionic strength (cation concentration, 0.1 mM–50 mM; cation type, Na+, and Ca2+), and humic acid (HA; 0–10 mg/L), on the transport behavior of BC-NP via systematic column experiments. The transportability of BC-NP in the soil-packed column decreased with decreasing soil grain size and was inversely proportional to soil clay content. At low cation concentrations (0.1–1.0 mM), a considerable proportion of BC-NP (15.95%–67.17%) penetrated the soil columns. Compared with Na+, Ca2+ inhibited the transportability of BC-NP in the soil through a charge shielding effect. With increasing HA concentration, the transportability of BC-NP increased, likely due to an enhanced repulsion force between BC-NP and soil particles. However, at a high HA concentration (10 mg/L), Ca2+ bridging reduced the transportability of BC-NP in the soil. Breakthrough curves of BC-NP were explained by the two-site kinetic retention model. The antagonistic effects of ionic strength and HA indicated that the transport behavior of BC-NP in the soil was governed by competitive effects of some environmental factors, including soil grain size, environmental solution chemistry, and natural organic matter content.
Comparative transcriptome analyses of immune responses to LPS in peripheral blood mononuclear cells from the giant panda, human, mouse, and monkey
Authors: Li Shun , Li Caiwu , Chen Lixiang , Yang Hua , Ren Xiaonan , Xu Chunhua , Wu Bin , Wang Chao , Ling Yun , Shen Yinzhong , Lu Hongzhou , Liu Weiping , Zhou Xiaohui 
Published: January 2023

Gram-negative bacteria are major pathogens that can cause illnesses in giant pandas. Lipopolysaccharides (LPS), components of Gram-negative bacteria, can activate immune responses in mammals (i.e., humans and mice) through recognition by toll-like receptors (TLRs). However, the giant pandas’ immune response to LPS stimulation and the differences between the giant panda and other mammals are not fully known. In this study, we administrated peripheral blood mononuclear cells (PBMCs) from giant pandas, humans, C57BL/6 mice, and rhesus monkeys by LPS treatment at 6 h followed by RNA sequencing (RNA-seq), respectively, with control of non-stimulation. KEGG analyses of differentially expressed genes (DEGs) pathways indicated that LPS could activate the classic signaling pathway of NF-κB in PBMCs from those four tested species. Thus, similar to the other three species, NF-κB is an LPS-responsive regulator of innate immune responses in giant pandas. Furthermore, the expression patterns of adapter genes, inflammatory cytokine genes, chemokines, interferon genes, cytokine genes related to cell growth and development, costimulatory molecules, Th1/Th2 cytokine genes, Th17 cytokine genes, Th9, and Th22 cytokine genes were compared among giant pandas and three other species. Our data indicated that in addition to the similar expression patterns of certain genes among giant pandas and other species, the unique expression pattern response to LPS in giant pandas was also discovered. Furthermore, Th9, Th17, and Th22 cells might be involved in the response to LPS in giant pandas at this tested time point. This study reveals that LPS-induced immune responses have different sensitivities and response timelines in giant pandas compared with other mammals. This study facilitates further understanding of the role of the TLR signaling pathway and the immune system in giant pandas, which might be helpful for disease prevention and protection.
Identification of ubiquitination-related gene classification and a novel ubiquitination-related gene signature for patients with triple-negative breast cancer
Authors: Zhao Kankan , Zheng Yuan , Lu Wenliang , Chen Bo 
Published: January 2023

Background: Ubiquitination-related genes (URGs) are important biomarkers and therapeutic targets in cancer. However, URG prognostic prediction models have not been established in triple-negative breast cancer (TNBC) before. Our study aimed to explore the roles of URGs in TNBC.Methods: The Molecular Taxonomy of Breast Cancer International Consortium (METABRIC) and the Gene Expression Omnibus (GEO) databases were used to identify URG expression patterns in TNBC. Non-negative matrix factorization (NMF) analysis was used to cluster TNBC patients. The least absolute shrinkage and selection operator (LASSO) analysis was used to construct the multi-URG signature in the training set (METABRIC). Next, we evaluated and validated the signature in the test set (GSE58812). Finally, we evaluated the immune-related characteristics to explore the mechanism.Results: We identified four clusters with significantly different immune signatures in TNBC based on URGs. Then, we developed an 11-URG signature with good performance for patients with TNBC. According to the 11-URG signature, TNBC patients can be classified into a high-risk group and a low-risk group with significantly different overall survival. The predictive ability of this 11-URG signature was favorable in the test set. Moreover, we constructed a nomogram comprising the risk score and clinicopathological characteristics with favorable predictive ability. All of the immune cells and immune-related pathways were higher in the low-risk group than in the high-risk group.Conclusion: Our study indicated URGs might interact with the immune phenotype to influence the development of TNBC, which contributes to a further understanding of molecular mechanisms and the development of novel therapeutic targets for TNBC.
Type 2 and type 17 effector cells are increased in the duodenal mucosa but not peripheral blood of patients with functional dyspepsia
Authors: Burns Grace L. , Bruce Jessica K. , Minahan Kyra , Mathe Andrea , Fairlie Thomas , Cameron Raquel , Naudin Crystal , Nair Prema M. , Potter Michael D. E. , Irani Mudar Zand , Bollipo Steven , Foster Robert , Gan Lay T. , Shah Ayesha , Koloski Natasha A. , Foster Paul S. , Horvat Jay C. , Veysey Martin , Holtmann Gerald , Powell Nick , Walker Marjorie M. , Talley Nicholas J. , Keely Simon 
Published: January 2023

BackgroundFunctional dyspepsia is characterised by chronic symptoms of post-prandial distress or epigastric pain not associated with defined structural pathology. Increased peripheral gut-homing T cells have been previously identified in patients. To date, it is unknown if these T cells were antigen-experienced, or if a specific phenotype was associated with FD.ObjectiveThis study aimed to characterise T cell populations in the blood and duodenal mucosa of FD patients that may be implicated in disease pathophysiology.MethodsWe identified duodenal T cell populations from 23 controls and 49 Rome III FD patients by flow cytometry using a surface marker antibody panel. We also analysed T cell populations in peripheral blood from 37 controls and 61 patients. Where available, we examined the number of duodenal eosinophils in patients and controls.ResultsThere was a shift in the duodenal T helper cell balance in FD patients compared to controls. For example, patients had increased duodenal mucosal Th2 populations in the effector (13.03 ± 16.11, 19.84 ± 15.51, p=0.038), central memory (23.75 ± 18.97, 37.52 ± 17.51, p=0.007) and effector memory (9.80±10.50 vs 20.53±14.15, p=0.001) populations. Th17 populations were also increased in the effector (31.74±24.73 vs 45.57±23.75, p=0.03) and effector memory (11.95±8.42 vs 18.44±15.63, p=0.027) subsets. Peripheral T cell populations were unchanged between FD and control.ConclusionOur findings identify an association between lymphocyte populations and FD, specifically a Th2 and Th17 signature in the duodenal mucosa. The presence of effector and memory cells suggest that the microinflammation in FD is antigen driven.