bluuebunny/crossref_metadata_2025_split huggingface dataset:
“Give up your mic”: Building capacity and sustainability within community‐based participatory research initiatives
Authors: April Keisha , Stenersen Madeline R. , Deslandes Maguena , Ford Taylor C. , Gaylord Patricia , Patterson Jacqúese , Wilson Beresford , Kaufman Joy S. 
Published: April 2023

AbstractCommunity‐based participatory research (CBPR) partnerships strive to promote community capacity building and sustainability, yet initiatives often suffer when grants or relationships with academic partners end. To address these concerns, researchers hoping to develop truly sustainable CBPR partnerships should consider factors that promote the development of community capacity and, ultimately, independence. In this first‐person account, using perspectives gathered from FAVOR, a Connecticut‐based family‐led advocacy organization and an academic researcher, we examine the practices and experiences of the members of a CBPR partnership focused on using community voice to inform changes in the state's children's behavioral health system of care. These practices ultimately led to FAVOR developing the necessary skills to assume full ownership of the community data‐gathering initiative, ensuring that the initiative would be sustained. Through the perspectives of five FAVOR staff and an academic researcher, we describe the factors that contributed to the organization being able to develop the capacity to independently continue their community data‐gathering initiative, including description of the training process and staff members' perspectives on training, autonomy, community value, and lessons learned. We use these stories and experiences to provide recommendations for other partnerships striving to promote capacity building and sustainability through community ownership of the research process.
Synthesis of multifunctional rubber chemicals 2‐propanol, 1‐(2‐benzothiazolylthio)‐3‐[3‐(triethoxysilyl) propoxy] silane and its application in natural rubber/silica composites
Authors: Sun Abin , Tao Anmin , Yao Binbin , Yu Guangshui , Kan Ze 
Published: April 2023

AbstractIn order to inhibit the agglomeration of silica in the rubber matrix, a new multifunctional rubber chemicals 2‐propanol, 1‐(2‐benzothiazolylthio)‐3‐[3‐(triethoxysilyl) propoxy] silane (Si‐GM) was synthesized by (3‐glycidyloxypropyl) trimethoxysilane (A‐1871) and 2‐mercaptobenzothiazole (MBT). Natural rubber (NR)/silica composites were prepared with different Si‐GM contents and its application in silica/NR composites obtained were researched. Experimental results show that the maximum and minimum torques of silica‐filled NR decrease with increasing the content of Si‐GM. With the addition of Si‐GM, the rubber compound has excellent characteristics of both fast vulcanization rate and high processing safety. Si‐GM can effectively improve the dispersion of precipitated silica in composites and strengthen the interaction between silica particles and NR matrix. It was found that Si‐GM considerably enhanced the mechanical properties such as the tensile and tear strength, dynamic compression property, and abrasion resistance of silica/NR composites, and the enhancements reached the maximum at the 5‐phr content of Si‐GM. In addition, by adding 4‐phr Si‐GM into the system, silica/NR composites acquired the superior comprehensive dynamic performances.
Using simple economic games to assess social orienting and prosocial behavior in adolescents with autism spectrum disorder
Authors: Hase Adrian , Haynes Melanie , Hasler Gregor 
Published: April 2023

AbstractDeficits in socio‐emotional reciprocity, in prosocial behavior and in developing social relationships are diagnostic criteria of autism spectrum disorder (ASD), usually assessed by self‐report or observation. Simple social experiments developed by behavioral economists allow for quantification of ASD‐related social behavior. In this study, we used such experiments to compare social‐economic decision‐making between ASD adolescents and neurotypical controls. Precisely, we analyzed social orienting and prosocial behavior in 17 adolescents with ASD (Asperger syndrome) and 24 matched neurotypical adolescents. We used a two‐condition distribution game (possibility of punishment by fellow player versus no such possibility) and an impunity game to examine social orienting (distribution game) and prosocial behavior (both games). Participants with ASD exhibited less social orienting in the distribution game (p = 0.03, d = −0.61). In addition, there was a trend for ASD participants to behave in a more prosocial way than neurotypical participants in the impunity game (p = 0.08, d = 0.60), which was not the case in the no‐punishment condition of the distribution game (p = 0.35, r = 0.17). These results demonstrate the potential of simple economic games to capture reduced social orienting in ASD. The unexpected finding of more prosocial behavior in adolescents with autism spectrum disorder than in neurotypical controls adds to the complexity of previously published results. We recommend meta‐analytic efforts to determine average effect sizes across studies and elucidate the conditions for prosocial behavior in ASD to occur.
High‐Mass‐Loading CoNi‐Layered Double Hydroxide Directly Grown on Brush‐like Cu/Carbon Cloth as High‐Areal‐Capacitance Supercapacitor Electrode
Authors: Feng Yichen , Yang Zhuang , Fang Yu‐Hung , Chen Ying‐Chu , Hsu Yu‐Kuei 
Published: April 2023

AbstractA combination of high mass loading and efficient utilization of electroactive materials is crucial for simultaneously enhancing the energy and power densities of energy storage devices. This is exemplified herein using cobalt nickel layered double hydroxides nanosheets (CoNi‐LDHs) directly grown on copper nanowires (Cu NWs) standing quasi‐vertically on carbon cloth (CC) to yield a multi‐core‐shell CoNi‐LDHs/Cu NWs/CC as the supercapacitor electrode that exhibits a high areal capacitance of 5.55 F cm−2 (corresponding to a gravimetric capacitance of 1209.15 F g−1) at a large current density of 10 mA cm−2. Such superior rate capability is attributed to the high packing density of CoNi‐LDHs in the electrode, benefitting from the large specific surface area of Cu NWs/CC. Additional contribution stems, on the other hand, from the facile charge transfer kinetics resulted from the elimination of binder from the electrode coupled with the mesopores between not only Cu NWs but also CoNi‐LDHs nanosheets, and the macropores between the carbon fiber of CC. Benefitting from such exceptional rate performance is the supercapacitor built on CoNi‐LDHs/Cu NWs/CC as the positive electrode coupled with bismuth subcarbonate (Bi2O2CO3) as the negative electrode capable of delivering outstanding power density of 13.31 mW cm−2 and energy density of 0.35 mWh cm−2.
Refining the Grain Size of Zinc Electrodeposit by Pb2+ Ion Grinding for Compact and Stable Zinc Anode
Authors: Cui Yang‐Feng , Cao Ren‐Fei , Hao Qi , Zhuang Zhen‐Bang , Xie Zi‐Long , Chen Hao , Li Kai , Wang Qingshuang , Liu Wan‐Qiang , Yang Yingkui , Huang Gang , Zhu Yunhai 
Published: April 2023

AbstractRecently, aqueous zinc‐based batteries (AZBs) have become a promising candidate for energy storage devices due to the high safety of aqueous electrolytes and the appealing features of Zn anodes, for example, low cost and high theoretical capacity. However, the excessive growth of Zn electrodeposits as well as the uneven stacking of large hexagonal Zn crystal units always render loose and irregular electrodeposition or even dendritic growth, which seriously deteriorates the actual performance of AZBs. Herein, to refine the grain size of Zn electrodeposits, a trace of Pb2+ ions as a novel electrolyte additive is performed to inhibit the growth of Zn grain during the Zn electrodeposition. Owing to the higher adsorption energy of Pb2+ ions on Zn crystal when compared with Zn2+ ions, the strongly positively‐charged Pb2+ ions are tightly absorbed on the typical crystal planes of initially‐formed Zn nuclei, which block the way for the subsequent absorption and electroreduction of Zn2+ ions. As a result, the Pb2+ ions‐containing electrolyte refines the grain size of Zn electrodeposits from 7.43–7.87 μm to 0.88–2.26 μm, and affords a high reversibility of Zn plating/stripping behavior with a high Coulombic efficiency of 99.9 % over 1000 cycles.
Determination of the absolute Raman cross‐sections of α‐S8 film at ultralow frequencies pumped by 488 and 785 nm lasers
Authors: Shin Mingyeong , Park Jinsun , Jeong Keunhong , Park Myeongkee 
Published: April 2023

AbstractAbsolute Raman cross‐sections are widely used for quantitative analyses of condensed phases. However, solid thin films showing ultralow frequency (ULF) Raman characteristics at <100 cm−1 have not been studied deeply. Herein, we demonstrate an ULF Raman spectrometer equipped with 488 and 785 nm pumped lasers and determine the absolute Raman cross‐sections of 34‐μm‐thick α‐S8 film, which presents Raman peaks at approximately 27, 50, 83, 154, and 220 cm−1. These experimentally measured ultralow Raman frequencies and Raman cross‐sections were also confirmed via first principles density functional theory. Thus, our Raman cross‐section studies can be utilized as a quantitative standard for thin films showing ULF Raman characteristics.
Liquid chromatography coupled with tandem mass spectrometry for simultaneous quantification of valproate, valproate‐glucuronide and lamotrigine in various biological matrices of rat
Authors: Qiu Fiona , Nie Shuai 
Published: April 2023

AbstractValproate and lamotrigine are commonly used as antiepileptic drugs even in pregnant and breastfeeding women. The extent and effects of drug exposure on the developing brain of the offspring are not well understood. Animal models can be utilised to investigate the transfer of substances into fetal brain with the ultimate aim of providing insights to aid clinical decisions. In the present study, an LC–MS/MS method was developed and validated for quantification of valproate (VPA), valproate‐glucuronide (VPA‐Gluc, a major metabolite of valproate) and lamotrigine (LTG) in rat blood plasma, cerebrospinal fluid and brain tissue. A 10 μl sample was spiked with stable isotope‐labelled internal standards and extracted by methanol. An Agilent RRHD Eclipse Plus C18 column (2.1 × 100 mm, 1.8 μm) was used. The MS/MS transitions were 143.1016–143.1016 (VPA), 319.1392–143.0978 (VPA‐Gluc) and 256.0157–210.9826 (LTG). The linear ranges of VPA, VPA‐Gluc and LTG were 30–250, 10–140 and 0.3–1 μg/ml, respectively. The intra‐ and inter‐day accuracy and precision, carryover, sensitivity and recovery were evaluated according to the US Food and Drug Administration guidance for bioanalytical method validation. Finally, the validated method was applied to a set of experimental animal samples and produced results highly comparable with those from an orthogonal analytical method.
Engineering a conduction‐consistent cardiac patch with graphene oxide modified butterfly wings and human pluripotent stem cell‐derived cardiomyocytes
Authors: Tan Yao , Lu Tingting , Chen Ying , Witman Nevin , Yan Bingqian , Yang Li , Liu Minglu , Gong Yiqi , Ai Xuefeng , Luo Runjiao , Wang Huijing , Wang Wei , Fu Wei 
Published: April 2023

AbstractEngineering a conduction‐consistent cardiac patch has direct implications to biomedical research. However, there is difficulty in obtaining and maintaining a system that allows researchers to study physiologically relevant cardiac development, maturation, and drug screening due to the issues around inconsistent contractions of cardiomyocytes. Butterfly wings have special nanostructures arranged in parallel, which could help generate the alignment of cardiomyocytes to better mimic the natural heart tissue structure. Here, we construct a conduction‐consistent human cardiac muscle patch by assembling human induced pluripotent stem cell‐derived cardiomyocytes (hiPSC‐CMs) on graphene oxide (GO) modified butterfly wings. We also show this system functions as a versatile model to study human cardiomyogenesis by assembling human induced pluripotent stem cell‐derived cardiac progenitor cells (hiPSC‐CPCs) on the GO modified butterfly wings. The GO modified butterfly wing platform facilitated the parallel orientation of hiPSC‐CMs, enhanced relative maturation as well as improved conduction consistency of the cardiomyocytes. In addition, GO modified butterfly wings enhanced the proliferation and maturation characteristics of the hiPSC‐CPCs. In accordance with data obtained from RNA‐sequencing and gene signatures, assembling hiPSC‐CPCs on GO modified butterfly wings stimulated the differentiation of the progenitors into relatively mature hiPSC‐CMs. These characteristics and capabilities of GO modified butterfly wings make them an ideal platform for heart research and drug screening.
Influence of superheated steam treatment on physicochemical, edible, and storage characteristics of highland barley grains
Authors: Liu Xinru , Fu Shijian , Deng Jiawen , Chen Zhicheng , Zhao Beibei , Li Hua 
Published: April 2023

AbstractBackground and ObjectivesThe effects of superheated steam (SS) processing conditions on physicochemical properties and edible qualities of highland barley (HB) grains are still not clear enough. The storage stability of SS treated HB grains is also need to be verified through long‐term storage. Effects of SS treatment on physicochemical, edible and storage properties of HB grains were investigated.FindingsSS processing significantly reduced peroxides and polyphenol oxidase activities. Pasting properties showed that SS treatment resulted in significant increase of viscosity parameters. With improved hardness, gumminess, chewiness, and decreased cooking loss, the cooking and textural qualities were improved by SS processing. Storage properties showed that SS processing inhibited the increase of free fatty acid value, peroxide value and carbonyl value during storage, indicating that the oxidative rancidity of HB grains was retarded. SS treatment also maintained the water hydration properties, pasting properties, and textural properties during 6 months of storage.ConclusionsSS treatment significantly improved the edible and storage properties of HB grains.
Predictive influence of artificial intelligence‐based body composition analysis in trauma patients with pelvic injuries
Authors: Kolck Johannes , Schäfer Frederik Maximilian , Labbus Kirsten , Wittenberg Silvan , Hosse Clarissa , Auer Timo Alexander , Fehrenbach Uli , Geisel Dominik , Beetz Nick Lasse 
Published: April 2023

AbstractBackgroundHigh‐energy trauma patients represent the ultimate challenge to trauma care and are at risk of injury‐related mortality and morbidity—a common cause of loss of productivity. The aim of this study was to implement computed tomography (CT)‐derived, artificial intelligence (AI)‐based body composition analysis (BCA) to identify predictors of morbidity.MethodsRetrospectively, we enrolled 104 patients (38 females and 66 males) who underwent CT imaging for assessment of injuries caused by high‐energy trauma (motor vehicle accidents, falls from significant height, or blast injury). We sought to identify risk factors for prolonged length of stay in hospital and intensive care unit (ICU) and fractures requiring pelvic surgery. Cox and logistic regression analysis were performed using BCA parameters as covariates besides conventional risk factors. Additionally, the effects of pre‐existing conditions, obesity, and sarcopenia were analysed.ResultsIncreased subcutaneous adipose tissue (SAT), determined by BCA, at hospital admittance is a predictor of prolonged hospital stay (P = 0.02) independent of treatment regime and occurrence of related complications, whereas muscle mass does not influence the length of stay. Individuals with sarcopenia and a decreased psoas muscle index (PMI) sustaining high‐energy trauma are at risk of pelvic injuries requiring surgical treatment.ConclusionBCA parameters are easily available from routine CT and significantly predict outcomes in trauma patients with pelvic injuries. Patients with reduced muscle mass are at risk for injuries requiring pelvic surgery, and increased SAT is a risk factor for longer hospital stays. These findings underline the potential of BCA, which may be valuable in identifying trauma patients who require specific support to optimize their physiological reserves and clinical outcome.
A follow‐up questionnaire survey 2022 on radiation protection among 464 medical staff from 34 endoscopy–fluoroscopy departments in Japan
Authors: Hayashi Shiro , Takenaka Mamoru , Kogure Hirofumi , Yakushijin Takayuki , Nakai Yousuke , Ikezawa Kenji , Yamaguchi Shinjiro , Fujisawa Toshio , Tamaru Yuzuru , Maetani Iruru , Maruyama Hirotsugu , Asai Satoshi , Takagi Tadayuki , Nagaike Koji , Hori Yasuki , Sumiyoshi Tetsuya , Tsumura Hidetaka , Doyama Hisashi , Yoshio Toshiyuki , Hara Kazuo , Abe Seiichiro , Oda Ichiro , Kato Motohiko , Nebiki Hiroko , Mikami Tatsuya , Miyazaki Masanori , Matsunaga Kazuhiro , Hosono Makoto , Nishida Tsutomu ,   REX‐GI Study Group
Published: April 2023

AbstractObjectivesWe surveyed and reported low protective equipment usage and insufficient knowledge among endoscopy‐fluoroscopy departments in Japan in 2020. Two years later, we conducted a follow‐up survey of doctors, nurses, and technologists in Japan.MethodsWe conducted a questionnaire survey on radiation protection from May to June 2022. The participants were medical staff, including doctors, nurses, and radiological and endoscopy technicians in endoscopy‐fluoroscopy departments. The questionnaire included 17 multiple‐choice questions divided into three parts: background, equipment, and knowledge.ResultsWe surveyed 464 subjects from 34 institutions. There were 267 doctors (58%), 153 nurses (33%), and 44 technologists (9%). The rate of wearing a lead apron was 98% in this study. The rates of wearing a thyroid collar, lead glasses, and radiation dosimeter were 27%, 35%, and 74%, respectively. The trend of the protective equipment rate was similar to that of our previous study; however, radiation dosimetry among doctors was still low at 58%. The percentage of subjects who knew the radiation exposure (REX) dose of each procedure was low at 18%. Seventy‐six percent of the subjects attended lectures on radiation protection, and 73% knew about the three principles of radiation protection; however, the concept of diagnostic reference levels was not well known (18%). Approximately 60% of the subjects knew about the exposure dose increasing cancer mortality (63%) and the 5‐year lens REX limit (56%).ConclusionsThere was some improvement in radiation protection equipment or education, but relatively little compared to the 2020 survey of endoscopy departments.
Generation of floxed Spag6l mice and disruption of the gene by crossing to a Hprt‐Cre line
Authors: Man Yonghong , Li Wei , Yap Yi Tian , Kearney Alivia , Yee Siu‐Pok , Strauss Jerome F. , Harding Pamela , Song Shizheng , Zhang Ling , Zhang Zhibing 
Published: April 2023

SummaryMouse sperm‐associated antigen 6 like (SPAG6L) is an axoneme central apparatus protein, essential for the normal function of the ependymal cell and lung cilia, and sperm flagella. Accumulated evidence has disclosed multiple biological functions of SPAG6L, including ciliary/flagellar biogenesis and polarization, neurogenesis, and neuronal migration. Conventional Spag6l knockout mice died of hydrocephalus, which impedes further investigation of the function of the gene in vivo. To overcome the limitation of the short lifespan of conventional knockout mice, we developed a conditional allele by inserting two loxP sites in the genome flanking exon 3 of the Spag6l gene. By crossing the floxed Spag6l mice to a Hrpt‐Cre line which expresses Cre recombinase ubiquitously in vivo, mutant mice that are missing SPAG6L globally were obtained. Homozygous mutant Spag6l mice showed normal appearance within the first week after birth, but reduced body size was observed after 1 week, and all developed hydrocephalus and died within 4 weeks of age. The phenotype mirrored that of the conventional Spag6l knockout mice. The newly established floxed Spag6l model provides a powerful tool to further investigate the role of the Spag6l gene in individual cell types and tissues.
Multi‐hazard fragility assessment of monopile offshore wind turbines under earthquake, wind and wave loads
Authors: Zhang Ziliang , De Risi Raffaele , Sextos Anastasios 
Published: April 2023

AbstractThis study establishes a multi‐hazard probabilistic assessment framework for assessing the integrity of monopile offshore wind turbines (OWT) under the stochastic coupled effect of wind, wave and earthquake loading. The procedure deals with the entire operational range of inflow wind speed (i.e., 3–25 m/s), for which the probability of failure under multi‐hazard excitations is found to be non‐negligible. Numerical analysis is performed by implementing nonlinear finite‐element models of the OWT developed in OpenSees. The dynamic response of the OWT system under wind‐ and wave‐load combinations is individually validated against those obtained from the aero‐hydro‐servo‐elastic simulator OpenFAST. Following the Latin‐hypercube approach, a cloud‐based assessment procedure is then performed with an ensemble of 300 earthquake ground motions, from which the multi‐hazard performance of the OWT regarding the serviceability limit state (SLS) and the ultimate limit state (ULS) can be evaluated. The epistemic uncertainty associated with various loads, structural properties, and soil conditions is also accounted for. Based on this probabilistic assessment framework, the sensitivity of the resulting OWT fragility surfaces to different statistical regression methods and wind—ground motion intensity measure pairs (IM‐pairs) is further scrutinised. Regression methods are comparatively evaluated. The efficiency, practicality, proficiency and sufficiency of various IM‐pairs are examined for the purpose of assessing operating OWT multi‐hazard fragility functions. The optimum IM‐pair is then employed in a trained Gaussian Process Regression (GPR) scheme for cloud data regression to assess the multi‐hazard fragility of the system. The derived multi‐hazard fragility function shows that the contribution of seismic forces in structural demand for a design‐level earthquake is comparable to those caused by operational‐level wind and wave loads.
Complete mimicry: Rhabdomyosarcoma with FUS::TFCP2 fusion masquerading as carcinoma—diagnostic challenge and report of two cases
Authors: Carrillo‐Ng Hugo , Liang Yu , Chang Sue , Afkhami Michelle , Gernon Thomas , Bell Diana , Arias‐Stella Javier A. 
Published: April 2023

AbstractRhabdomyosarcomas (RMS) are malignant mesenchymal tumors with skeletal muscle differentiation which are classified into alveolar, embryonal, pleomorphic, and spindle cell/sclerosing RMS. Within the spindle cell/sclerosing RMS tumor type there is a recently recognized sub‐type categorized as intraosseous spindle cell RMS with TFCP2/NCOA2 gene fusion. This rare tumor is highly aggressive with predominant involvement of the craniofacial and pelvic bones with approximately 30 cases reported to date. Histopathologic features include spindle cell and epithelioid morphology with a characteristic co‐expression of epithelial markers, myogenic markers, and ALK1 expression. We report two cases of gnathic spindle cell/sclerosing RMS with FUS::TFCP2 gene fusion that were initially interpreted as carcinomas by referring institutions and later reclassified when encountered in our practice after additional work‐up and molecular characterization.