bluuebunny/crossref_metadata_2025_split huggingface dataset:
Formulation and evaluation of novel nutraceuticals rich in protein, vitamins, minerals, natural flavors, and steviol glycosides for improving quality of life
Authors: Almoselhy Rania I.M. 
Published: August 2023

Abstract
For a wide range of people, including malnourished adults (12+) with non-communicable diseases (NCDs), micronutrient deficiency, underweight and overweight, pregnant and lactating women, the current study aimed to present novel nutraceuticals structured according to the Standards of Protein-Rich Concentrated Nutrient Supplementary Foods with Daily Value (DV) on the New Nutrition and Supplement Facts Labels of Food and Drug Administration (FDA), for improving quality of life (QoL). Whey protein concentrate, skim milk powder, vitamins (folic acid, B12, C), minerals (iron, zinc), natural flavors (vanilla, cinnamon, coffee, chocolate), and stevia leaves extract were mixed to provide per serving; 10 g protein (20% DV), 25% DV of elemental iron and zinc, vitamin C, folic acid, vitamin B12, with elemental calcium (25% DV) emerged from milk derivatives.. The novel nutraceuticals were subjected to the physicochemical, microbiological, and sensory evaluation. Results showed significant differences (P<0.05) among formulations with natural flavors added in different amounts. The serving sizes of the four formulations were different according to the difference in the amount of natural flavor while keeping the same amounts of the other ingredients. Following the chocolate-flavored formulation as the first in order of overall acceptability, were coffee, cinnamon, and vanilla-flavored formulation, according to the sensory evaluation.
COVID-19 Vaccination In Patients with Inborn Errors of Immunity Reduces Hospitalization and Critical Care Needs Related to COVID-19: A USIDNET Report
Authors: McDonnell John C 
Published: August 2023

Abstract
Background: The CDC and ACIP recommend COVID-19 vaccination for patients with inborn errors of immunity (IEI). Not much is known about vaccine safety in IEI and whether vaccination attenuates infection severity in IEI.
Objective:To estimate COVID-19 vaccination safety and examine effect on outcomes in patients with IEI.
Methods: We built a secure registry database in conjunction with the United States Immunodeficiency Network to examine vaccination frequency and indicators of safety and effectiveness in IEI patients. The registry opened on January 1, 2022 and closed on August 19, 2022.
Results: Physicians entered data on 1,245 patients from 24 countries. The most common diagnoses were antibody deficiencies (63.7%). At least 1 COVID-19 vaccine was administered to 806 patients (64.7%), and 216 patients received vaccination prior to the development of COVID-19. The most common vaccines administered were mRNA-based (84.0%). Seventeen patients were reported to seek outpatient clinic or emergency room care for a vaccine-related complication and one patient was hospitalized for symptomatic anemia. Eight hundred twenty-three patients (66.1%) experienced COVID-19 infection. Of these, 156 patients required hospitalization (19.0%), 47 required ICU care (5.7%), and 28 died (3.4%). Rates of hospitalization (9.3% versus 24.4%, p<0.001), ICU admission (2.8% versus 7.6%, p=0.013), and death (2.3% versus 4.3%, p=0.202) in patients who had COVID-19 were lower in patients who received vaccination prior to infection. In adjusted logistic regression analysis, not having at least one COVID-19 vaccine significantly increased the odds of hospitalization and ICU admission.
Conclusion: Vaccination for COVID-19 in the IEI population appears safe and attenuates COVID-19 severity.
The non-autonomous generalized perturbed KdV equation: its integrability, infinite conservation laws, multi soliton, high-order breather and hybrid solutions with mixed backgrounds
Authors: Raut Santanu , Kairi Rishi Raj , Chatterjee Prasanta , ROY SUBRATA 
Published: August 2023

Abstract
This paper claims the integrability of the non-autonomous generalized perturbed KdV (NgPKdV) equation through Painlevé analysis. Additionally, bilinear Bäcklund transformations, Lax pairs, and infinite conservation laws are developed to demonstrate the integrability of the said equation. Employing Hirota's approach, multi-solitons of the NgPKdV equation are constructed, from which the breather and hybrid solutions are explored with the proper choice of polynomial functions in the solution space. The changes in the behavior of non-autonomous solitons under different physical conditions are studied with special care. The propagating properties of single and double non-autonomous breathers along with their interactive properties with solitons are observed from the numerical viewpoint. An extensive study is also conducted on the propagation of solitary interactions and complex hybrid solutions.
PACS 52.30-q · 94.30.cq · 52.35.Fp
WITHDRAWN: Intermittent hypoxia ameliorates myocardial endoplasmic reticulum stress in infarcted mice via the p300/CBP-associated factor (PCAF) pathway
Authors: Ding Xinyu , Huang Chuan , Wang Junyi , Wan Chunxiao 
Published: August 2023

Abstract
Myocardial infarction (MI) is a common and frequent cardiovascular disease and its treatment is a major challenge in cardiovascular healthcare. Studies have demonstrated that intermittent hypoxia (IH) has therapeutic protective effects. Endoplasmic reticulum stress (ERS) and P300/CBP-associated factor (PCAF) are closely related to post-MI pathology. However, the effect of IH on ERS after infarction and the involvement of PCAF are unknown. First, 4 weeks of IH intervention was followed by observation of changes in left ventricular ejection fraction (LVEF) and shortening fraction (LVFS), levels of ERS-related proteins, and PCAF expression in the mice heart. Compared to the MI group, there was a significant increase in LVEF and LVFS, a significant decrease in myocardial fibrosis index, and a significant decrease in myocardial PCAF expression was significantly reduced, and ATF6, p-IRE1/IRE1, and CHOP expression was reduced in MI-IH group. Next, Mice were randomly classified into four groups, and the medication group was injected with embelin (PCAF inhibitor) (10mg/kg/d, i.p.). 4 weeks of intervention was followed by the same observations as in part I. Four weeks after intervention, LVEF and LVFS were elevated and myocardial fibrosis index was increased in the MI-IH-EMB group compared with the MI-EMB group; ATF6, p-IRE1/IRE1, and CHOP were decreased; the differences in LVEF, LVFS, myocardial fibrosis, and ERS-associated protein expression were not statistically significant between the MI-EMB group and MI-IH. Our findings suggested that IH inhibits ERS by down-regulating PCAF proteins, thereby exerting a protective effect on the heart.
Synergistic of nanoparticles and pretreatment on biogas yield from anaerobic co-digestion of municipal waste and sewage sludge
Authors: ahmadi-pirlou mansour , farajollahi Amirhamzeh , Rahmati AhmadReza 
Published: August 2023

Abstract
Municipal solid waste (MSW) and sewage sludge (SS) have a great potential for producing greenhouse gases and environmental pollution, and as such it would be beneficial to treat them and change them into biogas. Yet, a serious challenge is the complex structure of lignocellulose and the difficulty of its bioconversion. A solution to degrade the lignocellulose structure is the use of pretreatments and nanoparticles with proper concentrations. For this purpose, the synergistic effect of 6%NaOH pretreatment with different magnetite nanoparticles (MNP) concentrations was assessed for maximizing the biogas production. In this study, the optimalmixing ratio of MSW and SS co-digestion was determined from our previous studies (MSW:SS: 60:40). Application of the 6%NaOH pretreatment alone increased biogas and methane production by 24.6 and 35.4% respectively, compared to the control. Also, the 6%NaOH pretreatment alone elevated cellulose by 85% while reducing lignin and hemicellulose by 64and 33% respectively. The greatest biogas and methane production was obtained in the reactor of 6%NaOH with MNP concentration 110 ppm, experiencing 86 and 162% increase compared to the control. The greatest reduction in total solids and volatile solids was also obtained in this digestor by 76.6 and 79% respectively compared to the control reactor.
Structural Modeling of EFL/ESL Teachers’ Physical Activity, Mental Health, Psychological Well-being, and Self-efficacy
Authors: Guo Min , Jiang Shaohua 
Published: August 2023

Abstract
Physical activity (PA) is known to have positive effects on both the mental and physical health of individuals, especially those who experience high levels of stress, such as teachers. Previous studies have examined the relationship between teachers' PA, mental health, and well-being, but there is a lack of research on the direct and indirect effects of PA and self-efficacy. The purpose of this study was to investigate the structural relationship between teachers' PA, mental health, well-being, and self-efficacy among ESL/EFL teachers. A total of 364 Chinese English language teachers were selected through convenience sampling. Mental health, physical activity, psychological well-being, and self-efficacy instruments were used. The data was analyzed using Smart PLS software, and the hypothesized model was evaluated. The results indicated an acceptable level of divergent and convergent validity and goodness of fit. The findings revealed that PA is a direct predictor of teachers' mental health and well-being, but the direct structural relationship between teachers' PA and self-efficacy was not confirmed. However, the results showed that teachers' PA contributes to their self-efficacy by enhancing their mental health and psychological well-being. The total effect of teachers' PA on their self-efficacy was significant. Additionally, mental health and psychological well-being were found to be strong predictors of teachers' self-efficacy. In conclusion, regular weekly physical activity can help EFL/ESL teachers foster their mental health, psychological well-being, and self-efficacy. These findings have theoretical and practical significance for teachers, teacher trainers, and educational psychologists.
Factors Influencing Choice of Family MedicineSpecialty as a Future Career Among Tanta Medical Students
Authors: Abdel-bary Ibrahim , Rokia Ibrahim , Darwish Ibrahim , Abdelfatah Ahmed , Shams Ahmed , Abdallah Ahmed , afify Ahmed , Elshinawy Ahmed , Elbaz Ahmed , Alagal Ahmed , Fathy Ahmed 
Published: August 2023

Abstract
Background: Family medicine is a branch of medicine representing the primary healthcare facility and unfortunately still faces serious problems and shortage in Egypt and worldwide. Because of troubles facing medical students while choosing that speciality as a future career, most of them decide to neglect it.
The aim: was to raise the awareness of medical students and encourage them to pursue this specialty as a future career, with the goal of improving people health and reducing the tremendous strain on specialized hospitals.
Subjects and methods: An observational cross-sectional study was carried out targeting the undergraduate medical students at Tanta University using convenience sampling technique. Naturally, consent was taken first from them. The sample size was 346, and a Google form questionnaire was used to collect data from them. Analysis of that data was performed using SPSS software.
Results: The overall respondents were 346, Male participants were overwhelming and the most (99.4%) were single. A great percent had no physician member in family. Most of the respondents agreed that Egypt severely lacks family physicians and the most agreed that they receive insufficient financial return. Many agreed that family physicians don’t receive the necessary support from the health care system.
Conclusion: The students showed positive attitude toward family medicine. They acknowledgedthe integral role played by family physicians to improve the health sector. The majority of them are not planning to choose family medicine as a future career as it seems to be that their plans were influenced by many factors they settled.
Recommendations: were developed based on the students’ choices as the following: Dissemination of information about family medicine specialty. Requesting older family physicians to hold educational courses for trainee students
A rare case of bladder myiasis mimicking radiation cystitis: A first case report
Authors:   1)	Dr. Mahendra Kumar,   2)	Dr. Sujit Saikia,   3)	Dr. Anup Kumar Das,   4)	Dr. Debabrata Barmon,   5)	Dr. Upasana Baruah,   6)	Dr. Dimpy Begum,   7)	Dr. Sopouassi V. Nicholas King
Published: August 2023

Abstract
Background:
Patients diagnosed to have cancer post treatment are prone to have recurrent disease. Regular follow up of these patients enables early recognition and treatment. It is imperative to obtain a tissue diagnosis prior to starting treatment.
Case report:
We present a rare case of bladder myiasis. A 51 year old woman was referred to our institution post total abdominal hysterectomy with bilateral salpingo-opherectomy in view of post-menopausal bleeding and biopsy suggestive of papillary endometrioid endometrial carcinoma. She received adjuvant radiation external beam radiotherapy in view of high intermediate risk group (LVSI positive). She was diagnosed to have pelvic recurrence 5 years later for which she received palliative radiation. She presented with recurrent radiation cystitis which was initiated managed conservatively. On further evaluation she was diagnosed to have a bladder mass on ultrasound. She underwent cystoscopy and biopsy of bladder mass which was reported as bladder myiasis and successfully treated with single dose of Ivermectin. Post treatment there was resolution of the bladder mass and she was kept on regular follow up after educating for hygiene maintenance.
Conclusion:
It is important to ensure regular follow up of patients treated for gynaecological cancers given their immunosuppression. Moreover proper evaluation of recurrences avoids the potential harmful side effects of chemotherapy and radiation. It is recommended to increase awareness for hygiene in cancer survivor patients’ predominantly female patients.
A Moisture Detection Sensor for Flour Based on the Gas in Scattering Media Absorption Spectroscopy
Authors: Guo Xu , Meng Xingxing , Li Long , Qiu Xuanbing , Li Chuanliang , Guo Guqing , Sun Xiaocong , Gong Ting , Tian Yali 
Published: August 2023

Abstract
Flour is an essential ingredient in human daily diet, thus it is crucial to measure its moisture content. However, the detection of flour moisture content at present is time-consuming and labor-intensive, which makes it impossible to measure moisture quickly. This study demonstrates the measurement of moisture content in flour via gas in scattering media absorption spectroscopy (GASMAS) technique. A 1392 nm semiconductor laser is utilized as the light source, and a detector consisting of a photodiode and a transimpedance amplifier converts the light into an appropriately amplified signal. The output 2f signal is processed by the demodulation circuit board, and then converted by 16-bit ADC before being input to the STM32F405 for further processing. The equivalent average path length of ten flour samples from same brand and four from different brands are measured by GASMAS technique. Besides, to verify the measurement sensitivity of GASMAS, the equivalent mean path lengths of five flour samples from one brand with varying moisture content are measured. Furthermore, a linear relationship between path length and moisture content are established by least squares curve fitting, corresponds to a correlation coefficient of 0.996. Finally, to validate system accuracy and reliability, five samples with unknown moisture content are measured. Compared to the oven drying method, our method shows a maximum error range of 6.1 % for all samples, and GASMAS provides highly accurate and reliable measurement of water content in flour.
Using geometric wing morphometrics to distinguish Aedes japonicus japonicus and Aedes koreicus
Authors: Sauer Felix G. , Pfitzner Wolf Peter , Jöst Hanna , Rauhöft Leif , Kliemke Konstantin , Lange Unchana , Heitmann Anna , Jansen Stephanie , Lühken Renke 
Published: August 2023

Abstract

Background Aedes japonicus japonicus (Theobald, 1901) and Aedes koreicus (Edwards, 1917) have rapidly spread in Europe over the last decades. Both species are very closely related and occur in sympatry. Females are difficult to distinguish, and no distinctive morphological characters are known for males. However, the accurate species discrimination is important as both species may differ in their vectorial capacity and spreading behaviour. In this study, we assessed the potential of geometric wing morphometrics as alternative to distinguish the two species.Methods A total of 147 Ae. japonicus specimens (77 females and 70 males) and 124 Ae. koreicus specimens (67 females and 57 males) were collected in South-West Germany. The left wing of each specimen was removed, mounted and photographed. The coordinates of 18 landmarks on the vein crosses were digitalised by a single observer. The resulting two-dimensional dataset was used to analyse the differences in the wing size (i.e., centroid size) and wing shape between Ae. japonicus and Ae. koreicus by means of geometric morphometrics. To analyse the reproducibility of the analysis, the landmark collection was repeated for 20 specimens per sex and species by two additional observers.Results The wing size in female Ae. koreicus was significantly greater than in Ae. japonicus but did not differ significantly for males. However, the strong overlap in wing size also for the females would not allow to discriminate the two species. In contrast, the wing shape clustered species-specific and a leave-one-out validation resulted in a reclassification accuracy of 96.5% for the females and 91.3% for the males. The data collected by different observers resulted in a similar accuracy, indicating a low observer bias for the landmark collection.Conclusions Geometric wing morphometrics provide a reliable and robust tool to distinguish female and male specimens of Ae. japonicus and Ae. koreicus.
Impact of the basilar artery occlusion location on the recanalization rate and clinical outcome with endovascular therapy
Authors: Ni Heng , Zhao Lin-Bo , Ma Xinghua , Lv Penghua , Ding Yasuo , Liu Zhensheng , Shi Hai-Bin , Liu Sheng 
Published: August 2023

Abstract
Patients with basilar artery occlusion (BAO) stroke tend to have poor prognoses. This study aimed to explore the impact of the BAO location on the recanalization rate and clinical outcome after endovascular therapy (EVT). Patients with acute BAO who underwent EVT between March 2014 and October 2022 at four centers were included in this study. The BAO sites were classified as proximal, middle, and distal according to the angiographic findings. The favorable outcome measures for this study were successful recanalization, defined as modified thrombolysis in cerebral infarction score of 2b to 3, and a 90-day modified Rankin Scale (mRS) of 0 to 3. The association between the BAO location and clinical outcome following EVT was assessed. A total of 235 patients with BAO were analyzed, of whom 55 (22.3%) had proximal occlusion, 75 (30.4%) had middle occlusion, and 117 (47.4%) had distal occlusion. The rates of successful recanalization, first-pass recanalization, and favorable clinical outcome were significantly higher in the distal group than those in the proximal and middle groups (all P < 0.05). The multivariate-adjusted model showed that the BAO location did not impact clinical outcome (P = 0.249). However, the sensitivity analysis identified the distal BAO location as a predictor of favorable clinical outcome in patients with successful recanalization (adjusted odds ratio, 0.43; 95% confidence interval, 0.25–0.73; P = 0.002). The recanalization rate and clinical outcome for BAO after EVT differs according to the specific location. Distal BAO was associated with favorable clinical outcome after successful recanalization.
Robust Controller for a Quadratic Boost Converter
Authors: Oucheriah Said 
Published: August 2023

Abstract
Quadratic boost converters are highly nonlinear, high-order and nonminimum phase systems that present challenges to the regulation of their output voltages. In this paper, a robust nonlinear controller based on the uncertainty and disturbance estimator (UDE) scheme is successfully developed and implemented to tightly regulate the output voltage of the quadratic boost converter. The parameter uncertainties and disturbances are lumped as a signal and is accurately estimated using a low-pass filter. This estimate is then used by the controller to cancel the effect of the disturbances and uncertainties and this methodology forms the basis of the UDE-based controller. Using simulation, the effectiveness of the developed controller is compared with the widely popular proportional integral (PI) and sliding mode cascade controller that has shown excellent features in terms of output tracking abilities, robustness to system uncertainties and disturbances. Experimental results are also presented to validate the effectiveness and robustness of the proposed controller.
NAAA-regulated lipid signaling in monocyte-derived cells
controls the induction of hyperalgesic priming
Authors: Piomelli Daniele , Fotio Yannick , Tagne Alex Mabou , Squire Erica , Lee Hye-lim , Ahmed Faizy , Greenberg Andrew , Spadoni Gilberto , Mor Marco 
Published: August 2023

Abstract
Circulating monocytes and tissue-resident macrophages contribute in important ways to the transition from acute to chronic pain but the molecular events that cause their deployment are still unclear. Using a mouse model of hyperalgesic priming (HP), we show now that monocyte-derived cells enable the progression to pain chronicity through a cell-autonomous mechanism that requires the transient activation of the intracellular lipid hydrolase, N-acylethanolamine acid amidase (NAAA), and the consequent suppression of NAAA-regulated lipid signaling at peroxisome proliferator-activated receptor-α (PPAR-α). Inhibiting peripheral NAAA in the 72 hours following administration of one of three different priming stimuli (interleukin-6, tumor necrosis factor-α, or carrageenan), but not before or after this time interval, prevented the emergence of HP in male and female mice. This effect was phenocopied by global NAAA deletion and depended on the recruitment of PPAR-α by endogenous NAAA substrates. Transgenic mice selectively lacking NAAA in CD11b+ myeloid cells – which include monocytes, macrophages, and neutrophils – were resistant to HP induction. Conversely, mice overexpressing NAAA or lacking PPAR-α in the same cells were constitutively primed. In vivo ablation of monocytes, but not neutrophils, by administration of clodronate liposomes or blockade of type-1 colony-stimulating factor receptors, generated mice that were refractory to priming. The results identify NAAA-regulated lipid signaling in monocyte-derived cells as a control node in the induction of HP and the transition to pain chronicity.