bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Role of HERG channel in the Secretion of Glucagon-Like Peptide-1 (GLP-1) from Murine Intestinal L-Cells
Authors: Liu Chang , Yuan Ying-Chao , Xie Rong-Rong , Wang Hao , Yang Jin-Kui 
Published: March 2023

AbstractHERG ion channel is a member of the Voltage-gated potassium (Kv) channels. A reduction in HERG function reduces potassium efflux during repolarization. Previous research has shown that patients with long QT syndrome due to HERG mutations have increased secretion of the hormone glucagon-like peptide-1 (GLP-1). However, the role of HERG in GLP-1 secretion remains uncertain. Here we report that HERG is expressed in GLP-1-producing L-cells in rodent intestinal epithelium. In a mouse L-cell model (GLUTag cell line), downregulation of HERG significantly prolonged action potential duration, increased intracellular calcium concentration, and stimulated GLP-1 secretion after exposure to nutrients. These findings suggest that HERG in the intestine plays a direct role in GLP-1 secretion and may be a potential target for diabetes treatment.
Spatial intelligence: integration of land use to connectivity in the context of eastern urbanism
Authors: Srirangam Sucharita , Gunasagaran Sujatavani , Mari TamilSalvi , Ng Veronica , Kusumo Camelia May Li 
Published: March 2023

PurposeThere is an urgent need to develop a systematic tool for urban design in the cities of the Klang Valley, Malaysia. Sustainable Development Goal 11 (SDG11) proposes ideas to make cities and human settlements inclusive, safe, resilient and sustainable. This paper approaches this goal through land use, integrated into an effective connectivity network. It offers a scientific and systematic approach. The research employs Space Syntax of the University College London as a tool for urban analysis and the principles of Sustainable Street Networks developed by the Congress of New Urbanism to respond to connectivity issues.Design/methodology/approachThe paper employs empirical research through case studies. A systematic literature review is conducted on the diversified applications of the Space Syntax correlations, which steered the fundamental analysis of the elements of deconstruction to structure and land use. Space Syntax and Sustainable Street Network characteristics were the essential research methods. It is important to note that these data a new finding on the Syntactic Maps of the two case study cities.FindingsThe paper summarises a set of results on (1) international comparison of spatial intelligence, (2) patterns from the Eastern cases and (3) theoretical guidelines for spatial intelligence through the Syntax by offering key characteristics of the New Urbanism principles, which could be considered, while revitalising the cities in the Klang Valley, Malaysia.Research limitations/implicationsThe findings are specific and applicable to the oriental contexts. However, such results have been further compared to the Western context.Practical implicationsThe study develops a toolkit for urban planners and designers and architects in Klang Valley, Malaysia.Social implicationsThe research has focused and will add value for SDG11: Sustainable Cities and Communities. Theoretically, the paper offers insights to urban design readers.Originality/valueIt is important to note that the data itself is a new finding on Syntactic Maps of the two case study cities. The investigated setting is unique, and the first attempt in generating a Space Syntax map to the cities of Klang Valley, and the findings, therefore, offer a new set of knowledge-base to the city planners, urban designers, researchers and architects.
Implementing psychologically informed environments in homelessness services: a qualitative exploration of staff teams’ self-assessments
Authors: Buckley Sophie , Tickle Anna 
Published: March 2023

Purpose
This study aims to explore the perceptions of staff in four teams regarding the implementation of psychologically informed environments (PIE) across a community service and three hostels supporting individuals facing severe and multiple disadvantage.

Design/methodology/approach
Using a pre-post design, the PIEs Assessment and Self-Development for Services (known as the Pizazz) was completed by staff before the implementation of PIEs and at a six-month follow-up. A narrative review of the results and thematic analysis of the qualitative data are presented.

Findings
The majority of the Pizazz elements were rated as improved following PIE implementation. Thematic analysis developed three themes influencing staff members’ ability to develop a PIE: Complexities of Our and Wider Systems; Ready-made or Baked from Scratch; and Reflective and Responsive Staff.

Research limitations/implications
A planned one-year follow-up was obstructed by the coronavirus pandemic, limiting understanding of longer-term impact. Having only gathered data from staff members, the results cannot corroborate staff members’ perceptions. Further research could explore other stakeholder perspectives, as well as the impact of PIE implementation on staff perception of resources, and of a possible ceiling effect for hostels trying to develop PIE.

Originality/value
To the authors’ best of knowledge, this is the first UK study to use the Pizazz to evaluate the implementation of PIE.
Business model patterns in the 3D food printing industry
Authors: Nopparat Nanond , Motte Damien 
Published: March 2023

Purpose
Present for more than 20 years, 3D food printing (3DFP) technology has not experienced the same widespread adoption as its non-food counterparts. It is believed that relevant business models are crucial for its expansion. The purpose of this study is to identify the dominant prototypical business models and patterns in the 3DFP industry. The knowledge gained could be used to provide directions for business model innovation in this industry.

Design/methodology/approach
The authors established a business model framework and used it to analyse the identified 3DFP manufacturers. The authors qualitatively identified the market’s prototypical business models and used agglomerative hierarchical clustering to extract further patterns.

Findings
All identified 3DFP businesses use the prototypical business model of selling ownership of physical assets, with some variations. Low-cost 3D food printers for private usage and dedicated 3D food printers for small-scale food producers are the two primary patterns identified. Furthermore, several benefits of 3DFP technology are not being used, and the identified manufacturers are barely present in high-revenue markets, which prevents them from driving technological innovation forward.

Practical implications
The extracted patterns can be used by the companies within the 3DFP industry and even in other additive manufacturing segments to reflect upon, refine or renew their business model. Some directions for business model innovation in this industry are provided.

Originality/value
To the best of the authors’ knowledge, this is the first quantitative study to give an account of the current 3DFP business models and their possible evolution. This study also contributes to the business model patterns methodological development.
When should central banks engage in private sector securities purchases?
Authors: Michael Bryane , Dalko Viktoria 
Published: March 2023

Purpose The authors aim to look at the conditions under which central bank easing – and specifically the purchase of private sector securities – can/should contribute to growth, rather than fiscal policy and also ask when can the central bank’s purchase of private sector securities help supplant traditional monetary policy.Design/methodology/approachAfter surveying the existing literature, the authors use simple correlation of central bank private asset (stocks, bonds, etc.), interest rates, gross domestic product (GDP) growth, inflation and the extent of the functioning of domestic banking sectors (among others) to classify countries in which these purchases promote pro-growth investment.FindingsUnder the typical conditions for unconventional monetary policy, central bank purchases of private companies’ securities can promote growth in some places (like Bulgaria, the Ukraine, Georgia and Greece at the time of our writing) while hurting it in others (like in parts of Latin America and Africa in the mid-2010s). The authors find how such purchases effectively “bypass” dysfunctional banking systems and central/government local bodies fiscal spending, making the central bank the “funder of last resort” in many middle and lower income countries.Practical implicationsThis paper tells specific central banks to ramp up – or reduce – their purchases of private sector securities. The authors identify exact jurisdictions where such “helicopter money” has led to investment in the past economic growth.Originality/valueAll previous work on conventional and unconventional monetary policy has looked at the way monetary policy affects investment and growth through the banking system and holding companies’ reactions constant. The authors do the opposite – looking at how companies respond, holding banking system responses constant. No one has ever looked at these private purchases (taken from a special IMF database), much less tried to argue that central banks can sometimes target investment growth much better than fiscal policy. No one has ever considered them as a funder (rather than lender) of last resort.
Is knowledge hiding in higher education a political phenomenon? An explanatory sequential approach to explore non-linear and three-way interaction effects
Authors: Modem Roopa , Lakshminarayanan Sethumadhavan , Pattusamy Murugan , Pillai K. Rajasekharan , Prabhu Nandan 
Published: March 2023

Purpose
This study addresses a central research question: Is individuals’ propensity to hide knowledge a “political phenomenon” among researchers in the Indian higher education institutions? Drawing upon social exchange and uncertainty management theories, the authors examine how a three-way interaction effect of perceptions of organizational politics, political will and political skill contributes to knowledge hiding. In addition, this study aims to develop a nuanced understanding of the knowledge hiding phenomenon in the Indian higher education context.

Design/methodology/approach
This study adopts a mixed-method study design with an explanatory sequential approach. The authors gathered data through a cross-sectional survey of 286 researchers (Study 1) followed by two focus group discussions (Study 2) involving 13 academic researchers from five Indian universities. The sample includes full-time faculty members, postgraduate and full-time doctoral students engaged in research.

Findings
The results of Study 1 indicate that researchers’ perceptions of organizational politics positively relate to their knowledge hiding. The findings of this study also suggest that the positive relationship between perceptions of organizational politics and knowledge hiding turns negative for individuals with high political will and high political skill. The focus group discussions (Study 2) explore significant predictors of knowledge hiding. This study unveils various characteristics of knowledge, knowledge hider, knowledge seeker and interpersonal dynamics as the key drivers of knowledge hiding in Indian academia.

Originality/value
The significant contributions of this study are to provide new insights into the relationship between organizational politics and knowledge hiding and to unravel the various factors that incite knowledge hiding among researchers in the Indian higher education context. This study is one among the few in the knowledge hiding literature to adopt a mixed-method research design with an explanatory sequential approach.
War build-up and stock returns: evidence from Russian and Ukrainian stock markets
Authors: Najaf Khakan , Joshipura Mayank , Alshater Muneer M. 
Published: March 2023

PurposeThis study examined the impact of war/conflict-related news on the Russian and Ukrainian stock markets in the build-up and beginning of the war that sparked in the year 2022.Design/methodology/approachIn order to examine the impact of war-related news on stock returns, data were gathered from the United States (US) and Russian stock indices, oil price and volatile index (VIX) from Yahoo.finance; Ukrainian stock values from pfts.ua website and daily related news retrieved from nexis.com were analysed. The data were gathered from January 1, 2022 to February 24, 2022. Seeming unrealated regressions (SUR) and exponential generalised autoregressive conditional heteroscedastic (EGARCH) models were carried out to determine the formulated correlations. This study controlled the oil price, US stock returns, Chicago Board Options Exchange (CBOE) VIX and difference in stock returns of Russia and Ukraine.FindingsThe results are presented two-fold: first, war-related news between the two countries enhanced volatility and caused a significant decline in the stock market indices for both countries. Second, the Russian stock market faced a steeper decline in the build-up and the actual beginning of the war than the Ukrainian stock market. Notably, the Russian markets feared the adverse economic consequences that stemmed from the sanctions the US and the Western world imposed.Research limitations/implicationsAs this study was based on early evidence, future studies with a longer window may provide better insights. This present study is restricted to the stock returns of the countries directly involved in the build-up towards war. Studies focusing on the impact of other asset classes, currencies, commodities and global stock markets might offer holistic insights.Practical implicationsThe study outcomes suggest that global portfolio investors should stay away from stock markets of the war-raged countries and equity markets in general, but instead look for safe-haven assets.Originality/valueThe paper evaluates stock markets' performance during the pre-war period, considering the context of this historical war between the neighbours. It is important to understand this issue as this war is subject to sanctions by the US and leads to a global supply chain crisis.
Natural dyeing of silk and jute fabric with the aqueous extract of coconut leaves – an eco-friendly approach
Authors: Hossain Shahin , Jalil M. Abdul , Mahmud Rois Uddin , Kader Abdul 
Published: March 2023

Purpose
In recent years, natural dyes have attracted significant attention globally because of growing public awareness of the environment and health hazards associated with synthetic dyes. Natural dyes can provide special aesthetic qualities as well as the ethical significance of a product which is environmentally friendly. By keeping this burning issue in mind, this study aims to explore the dyeing properties of various unexplored environmentally friendly natural dyes.

Design/methodology/approach
In this study, the aqueous extract of coconut leaves is used for dyeing purpose. The silk and jute fabrics were dyed with the extract alone as well as in combination with metal salts as mordants by employing pre-, meta- and postmordanting techniques. The dyeing properties of the colored samples were evaluated by measuring their color strength; CIEL*a*b* values; and color fastness to washing, light and rubbing.

Findings
A yellow shade was achieved when the fabric samples were dyed solely with the extract. However, shade variations were observed when different mordants and mordanting techniques were applied. In all the cases, metallic salts improved the color fastness properties of dyed samples to washing, light and rubbing especially for the silk fabric.

Originality/value
To the best of the authors’ knowledge, this is the first report on a natural dye extracted from the leaves of coconut. Leaf as the source of dye has added an extra advantage, as it is reproducible and can be collected easily without harming the plants. The reported dye could be an attractive choice for sustainable and eco-friendly dyeing.
Combined analysis of resistivity and induced polarization tomography for 3D modelling and preliminary volume estimation of the possible gold mineralization zones in the Simi locality, Adamawa, Cameroon
Authors: Ndam Njikam Mohamed Moustapha , Yem Mbida , Meying Arsène , Ribodetti Alessandra , Messi Gabriel , Tethys‐Authie Chiewo Ceukou , Zoumanigui Jean Maoro 
Published: March 2023

AbstractThe present study attempts to combine direct current and induced polarization methods for 3D geological modelling and preliminary volume estimation of gold mineralization targets in the Simi locality, Adamawa, Cameroon. To begin, resistivity and chargeability data were collected along seven profiles oriented in N150E using the electrical tomography technique. A geological investigation was also carried out and allowed in addition to the geological formations to highlight the existence of gold mineralization in the study area. The interpretation of the inversion results was done by taking into consideration the geological field data and the existing resistivity charts. The 3D distribution of the interpreted sections allowed us to make a horizontal correlation between the different sections and to elaborate the 3D geological model of the study area by using the deterministic inverse distance method. The estimated model indicates a volume of 621,130.625 m3 of the possible gold complex. The gold complex was then divided into two mineralization domains based on chargeability ranges (mV/V): A first domain is associated with a major mineralization zone (39–60 mV/V) with a volume of 10,842 m3, and a second domain is associated with secondary mineralization zone (18–39 mV/V) with a volume of 610,288 m3. This model allows to compartmentalize the gold complex and can be used as a base model for the gold investigation in the study area.
Calibration of near‐surface multi‐frequency electromagnetic induction data
Authors: Finco Cécile , Rejiba Fayçal , Schamper Cyril , Cavalcante Fraga Luis Henrique , Wang Ao 
Published: March 2023

AbstractThe frequency‐domain electromagnetic induction method is a very efficient and convenient method to investigate a site of interest and for a large range of applications including hydrogeology and archaeology. Besides an easy infield acquisition, the data can be used to estimate the electrical, magnetic and, in certain cases, dielectric properties of the ground. It does, however, require calibration to get reliable quantitative values of these properties. We propose here an original and reliable self‐calibration method, specific to multi‐frequency measurements in the range of (5–100 kHz)‐based only on the consistency between the data at different acquisition frequencies. Contrary to other existing cross‐calibration procedures, no additional measurements with other methods are necessary. This self‐calibration (quadrature and in‐phase components of the electromagnetic induction signal) procedure is tested at a test site located at the centre for studies on risks, the environment, mobility and urban planning Normandie‐Centre facilities (Rouen, France). The developed quadrature self‐calibration has been successfully compared with the usual electrical resistivity tomography – electromagnetic induction cross‐calibration procedure. The main results reveal the potential of systematic assessment of all electromagnetic parameters from multi‐frequency and multi‐configuration electromagnetic induction data: The electrical resistivity and the magnetic susceptibility are estimated from the low‐frequency range, whereas the highest part of the frequency range is used for the dielectric permittivity.
The future of crime data
Authors: Lauritsen Janet L. 
Published: March 2023

AbstractCriminology lacks sufficient data for many types of crime that are of great concern to society. This lack of data poses significant problems for determining whether resources are adequate for responding to these crimes or whether programmatic, legislative, or target‐hardening efforts to prevent or reduce their occurrence are effective. Inadequate data about crime also produces a selective and incomplete narrative about crime that makes it easier for political and vested interests to exploit public concerns about crime for their own ends. In this address, I discuss what is needed to resolve these gaps and the ways in which criminologists can support a significant expansion of the crime data infrastructure. Such work is necessary to help ensure the future relevance of criminological research.
Autophagy in the retinal neurovascular unit: New perspectives into diabetic retinopathy
Authors: Yang Xiongyi , Huang Zexin , Xu Mei , Chen Yanxia , Cao Mingzhe , Yi Guoguo , Fu Min 
Published: March 2023

AbstractDiabetic retinopathy (DR) is one of the most prevalent retinal disorders worldwide, and it is a major cause of vision impairment in individuals of productive age. Research has demonstrated the significance of autophagy in DR, which is a critical intracellular homeostasis mechanism required for the destruction and recovery of cytoplasmic components. Autophagy maintains the physiological function of senescent and impaired organelles under stress situations, thereby regulating cell fate via various signals. As the retina's functional and fundamental unit, the retinal neurovascular unit (NVU) is critical in keeping the retinal environment's stability and supporting the needs of retinal metabolism. However, autophagy is essential for the normal NVU structure and function. We discuss the strong association between DR and autophagy in this review, as well as the many kinds of autophagy and its crucial physiological activities in the retina. By evaluating the pathological changes of retinal NVU in DR and the latest advancements in the molecular mechanisms of autophagy that may be involved in the pathophysiology of DR in NVU, we seek to propose new ideas and methods for the prevention and treatment of DR.
Exploratory analysis of immunochemotherapy compared to chemotherapy after EGFR‐TKI in non–small cell lung cancer patients with EGFR mutation: A multicenter retrospective study
Authors: Hata Tae , Sakaguchi Chikara , Hirano Keita , Kobe Hiroshi , Ishida Masaki , Nakano Takayuki , Tachibana Yusuke , Tamiya Nobuyo , Shiotsu Shinsuke , Takeda Takayuki , Yamada Tadaaki , Yokoyama Toshihide , Tsuchiya Michiko , Nagasaka Yukio 
Published: March 2023

AbstractBackgroundPatients with epidermal growth factor receptor (EGFR)‐mutated, advanced non–small cell lung cancer have received immunochemotherapy as one of the treatment options after tyrosine kinase inhibitor (TKI) failure.MethodsWe retrospectively examined EGFR‐mutant patients treated with atezolizumab‐bevacizumab‐carboplatin‐paclitaxel (ABCP) therapy or platinum‐based chemotherapy (Chemo) after EGFR‐TKI therapy at five institutions in Japan.ResultsA total of 57 patients with EGFR mutation were analyzed. The median progression‐free survival (PFS) and overall survival (OS) in the ABCP (n = 20) and Chemo (n = 37) were 5.6 and 20.9 months, 5.4 and 22.1 months, respectively (PFS, p = 0.39; OS, p = 0.61). In programmed death‐ligand 1 (PD‐L1)–positive patients, median PFS in the ABCP group was longer than in the Chemo group (6.9 vs. 4.7 months, p = 0.89). In PD‐L1–negative patients, median PFS in the ABCP group was significantly shorter than in the Chemo group (4.6 vs. 8.7 months, p = 0.04). There was no difference in median PFS between the ABCP and Chemo groups in the subgroups of brain metastases, EGFR mutation status, or chemotherapy regimens, respectively.ConclusionThe effect of ABCP therapy and chemotherapy was comparable in EGFR‐mutant patients in a real‐world setting. The indication for immunochemotherapy should be carefully considered, especially in PD‐L1–negative patients.