bluuebunny/crossref_metadata_2025_split huggingface dataset:
COVID-19 HEART unveiling as atrial fibrillation: pathophysiology, management and future directions for research
Authors: Kanuri Sri Harsha , Jayesh Sirrkay Prapthi , Ulucay Ayse Sena 
Published: April 2023

AbstractBackgroundCOVID-19 infections are known to cause numerous systemic complications including cardiovascular disorders. In this regard, clinicians recently noticed that patients recovering from COVID-19 infections presented with diverse set of cardiovascular disorders in addition to those admitted to ICU (intensive care unit). COVID-19 heart has multifaceted presentation ranging from dysrhythmias, myocarditis, stroke, coronary artery disease, thromboembolism to heart failure. Atrial fibrillation is the most common cardiac arrhythmia among COVID-19 patients. In the background section, we briefly discussed epidemiology and spectrum of cardiac arrhythmias in COVID-19 patients.Main bodyIn this state-of-the-art review we present here, we present the information regarding COVID-19-induced A-fib in sections, namely mechanism of action, clinical presentation, diagnosis and treatment. Unfortunately, its occurrence significantly increases the mortality and morbidity with a potential risk of complications such as cardiac arrest and sudden death. We included separate sections on complications including thromboembolism and ventricular arrhythmias. Since its mechanism is currently a gray area, we included a separate section on basic science research studies that are warranted in the future to comprehend its underlying pathogenic mechanisms.ConclusionsTaken together, this review builds upon the current literature of COVID-19-induced A-fib, including pathophysiology, clinical presentation, treatment and complications. Furthermore, it provides recommendations for future research moving forward that can open avenues for developing novel remedies that can prevent as well as hasten clinical recovery of atrial fibrillation in COVID-19 patients.
Effectiveness of PRISM III score in predicting the severity of illness and mortality of children admitted to pediatric intensive care unit: a cross-sectional study
Authors: Anjali M. M. , Unnikrishnan Deepa T. 
Published: April 2023

Abstract
Background
The facilities for intensive care are improving day by day in all departments including pediatrics, and prognostication has always been the duty of a physician. Scoring systems are useful to objectively measure the severity and predict the prognosis of sick children. This study was done to assess the severity of illness and mortality risk using the PRISM score in children aged 1 month–18 years, admitted into the pediatric intensive care unit in a tertiary-level hospital. Ninety children of age group 1 month–18 years admitted to the pediatric intensive care unit, satisfying the inclusion and exclusion criteria, were selected after obtaining consent from the parents. A careful history, physical examination, systemic examination, and relevant blood investigations were performed and documented based on the Pediatric Risk Mortality score (PRISM). The relationship between the total prism score obtained and the outcome in terms of mortality, and severity based on the need for either ventilator support or inotrope support or ICU stay of more than 5 days, was studied using appropriate statistical tools.

Results
The male to female ratio was 53.3% and 46.7%, with a mortality of 10% and severity of 24%. The average value of the PRISM score was 12 to predict mortality, with 100% sensitivity and 91% specificity. PRISM score of 7 had 100% sensitivity and 95% specificity in predicting severe illness. There was a significant association between a low Glasgow coma scale, pupillary reaction, low systolic blood pressure, acidosis, high blood glucose level, and high serum creatinine with the severity of illness.

Conclusions
The present study demonstrates that Pediatric Risk Mortality score III (PRISM III) acts as an excellent discriminative tool for predicting both mortality and severity of illness of children admitted to the pediatric intensive care unit. The area under the ROC curves was 99% for both. As the PRISM score increases, both mortality risk increases and the risk of severity of illness also increases.
Preoperative Risk Stratification in Esophageal Cancer Surgery: Comparing Risk Models with the Clinical Judgment of the Surgeon
Authors: Hagens Eliza R. C. , Cui Nanke , van Dieren Susan , Eshuis Wietse J. , Laméris Wytze , van Berge Henegouwen Mark I. , Gisbertz Suzanne S. 
Published: April 2023

Abstract
Background
Numerous prediction models estimating the risk of complications after esophagectomy exist but are rarely used in practice. The aim of this study was to compare the clinical judgment of surgeons using these prediction models.

Methods
Patients with resectable esophageal cancer who underwent an esophagectomy were included in this prospective study. Prediction models for postoperative complications after esophagectomy were selected by a systematic literature search. Clinical judgment was given by three surgeons, indicating their estimated risk for postoperative complications in percentage categories. The best performing prediction model was compared with the judgment of the surgeons, using the net reclassification improvement (NRI), category-free NRI (cfNRI), and integrated discrimination improvement (IDI) indexes.

Results
Overall, 159 patients were included between March 2019 and July 2021, of whom 88 patients (55%) developed a complication. The best performing prediction model showed an area under the receiver operating characteristic curve (AUC) of 0.56. The three surgeons had an AUC of 0.53, 0.55, and 0.59, respectively, and all surgeons showed negative percentages of cfNRIevents and IDIevents, and positive percentages of cfNRInonevents and IDIevents. This indicates that in the group of patients with postoperative complications, the prediction model performed better, whereas in the group of patients without postoperative complications, the surgeons performed better. NRIoverall was 18% for one surgeon, while the remainder of the NRIoverall, cfNRIoverall and IDIoverall scores showed small differences between surgeons and the prediction models.

Conclusion
Prediction models tend to overestimate the risk of any complication, whereas surgeons tend to underestimate this risk. Overall, surgeons’ estimations differ between surgeons and vary between similar to slightly better than the prediction models.
Treatment of perianal fistulas in Crohn’s disease - review of literature and current recommendations
Authors: Szawica Dominik , Kuźniar Aleksandra , Fularska Kamila , Oleszko Michał , Wąsiewicz Edward , Bernacki Radosław , Bernacki Piotr , Dutka Martyna , Zardzewiały Witold 
Published: April 2023

Introduction: Crohn's disease is an idiopathic inflammatory disorder of unknown etiology, associated with genetic, immunological, and environmental factors. The incidence of this disease continues to rise in developed countries. In almost 25% of patients, perianal fistulas occur during the course of the disease, which are difficult to treat and significantly impair the patient's quality of life.
Aim of the study: To summarize the current state of knowledge on the treatment of Crohn's disease with perianal fistulas, with a particular focus on biological therapies and stem cell treatments.
Methods and Materials: A systemic review was conducted using PubMed, Google Scholar, and ScienceDirect databases and it was limited to studies published in last 5 years. The search strategy was based on following terms: "Crohn's disease", "perianal fistula", "biological treatment", and "inflammatory bowel disease".
Results: In recent years, there has been intensive research into new treatment options for perianal fistulas in Crohn's disease. Infliximab remains the first-line therapy, best controlled by monitoring the drug concentration in the serum. Alternatively, other drugs such as ustekinumab and vedolizumab may be considered. The combination of biological and surgical treatment is a recognized standard of care and modern, minimally invasive techniques that preserve sphincters, such as the FiLaC™ laser procedure, are increasingly being used. A novel and very promising therapeutic approach is based on mesenchymal stem cells, which may offer hope for patients who do not improve with standard treatment.
Conclusion: Perianal disease in patients with Crohn's disease poses a significant therapeutic challenge and has a substantial negative impact on the physical and emotional well-being of patients. Despite the existence of various therapeutic options, a certain percentage of patients still fails to achieve clinical remission. Further research into new therapies is necessary.
The correlation between Yerba Mate and cancer - a review
Authors: Wróblewska Kinga , Wróblewski Hubert , Zajączkowska Monika , Wójtowicz Bartosz , Zimna Aleksandra , Zygmunt-Siembida Ewelina , Piecewicz-Szczęsna Halina 
Published: April 2023

Introduction and objective
Yerba Mate (YM) is a popular drink obtained from the dried and ground leaves of the Ilex paraguariens. The beneficial effects of Yerba Mate on the cardiovascular system, lipid-lowering, anti-diabetic, hepatoprotective and stimulating properties are known, however, there are also reports supporting its toxicity, that the consumption of Yerba Mate may predispose to the development of cancer. The purpose of this article is to present and organize information on the correlation between drinking Yerba Mate and cancer.
Review methods
A review of the available literature was performed by searching the PubMed and Google Scholar databases using the following keywords: Yerba Mate and cancer, Yerba Mate.
Abbreviated description of the state of knowledge
Substances contained in Yerba Mate have a positive impact on the human body. They exert health-promoting effects, e.g. increasing HDL levels and enhancing the antioxidant effect. A particularly desirable effect of Yerba Mate is its modulating effect on the course of the carcinogenesis process. Current knowledge on this subject is not complete. There are no evidences that substances in Yerba Mate without other risk factors increase the risk of oesophageal cancer. It is worth emphasizing that the properties of the Yerba Mate components are related to the reduction of the development of metastases of other cancers.
Summary
Despite the carcinogenic PAHs contained in the YM extract, there is no clear evidence that drinking it alone, without taking into account the temperature of the drink, could predispose to the development of esophageal cancer. Many substances found in YM have a beneficial effect on the human body.
Efficacy of ultrasonography-guided compared to surface landmark-based corticosteroid injection for people with chronic pes anserine tendinitis or bursitis: a randomised controlled trial
Authors: Zavarei Sarvenaz , Soltani Shayesteh Khalifeh , Raissi Gholamreza , Babaei-Ghazani Arash , Safarnezhad Saeed , Soleymanzadeh Hosnieh , Ahadi Tannaz 
Published: April 2023

Background/Aims One of the main aetiologies of patients' symptoms who have degenerative knee disease is pes anserine tendinitis or bursitis. Local corticosteroid injection is an effective treatment for chronic cases. The aim of this study was to compare the efficacy of an ultrasonography-guided corticsosteroid injection vs a landmark-based injection. Methods A total of 31 patients with clinical chronic (>3 months) pes anserine tendinitis bursitis, confirmed by ultrasonography, were randomised into two groups. One group received a corticosteroid injection (40 mg triamcinolone acetonide) with ultrasonographic guidance, and the other group received a corticosteroid injection without ultrasonographic guidance. Participants and the assessor were blind to the type of procedure. Participants were clinically assessed using the Western Ontario and McMaster University knee questionnaire before and 2 weeks after the injection and a visual analogue scale before, 2 and 12 weeks after the injection. Results There were significant decreases for both groups in the visual analogue scale at 2 weeks and 12 weeks after the injection, with a superior decline in the ultrasound-guided group (mean difference: 60.00, P<0.001 in ultrasound-guided group, and mean difference: 25.33, P<0.022 in the surface landmark-based group). The Western Ontario and McMaster University questionnaire scores also demonstrated significant improvement in both groups, with no preferential difference between groups (mean difference: 26.87, P<0.001 in the ultrasound-guided group, and mean difference: 22.20, P<0.001 in the surface landmark-based group). Conclusions Steroid injection is an effective treatment to manage chronic pes anserine bursitis, and ultrasonography guidance may further improve clinical outcomes.
Tang Hanedanlığı Dönemi Çin Müziği ve Türk Kavimlerinin Çin Müziğine Etkileri
Authors: PAMUK ÖZTÜRK Nuray 
Published: April 2023

Tang Hanedanlığı, Çin tarihinde kültürel ve edebi zenginliğin en fazla görüldüğü dönemdir. Bu dönemde Türk kavimleriyle yaşanan askerî mücadeleler dışında Türk kültürünün Çin kültürüne yansımaları da açıkça görülmektedir. Kültürel yansımalardan bir tanesi olan müzik, çalışmamızın ana konusunu oluşturmaktadır. Türk kavimlerinin geniş bir coğrafi alanı kapsıyor olması sebebiyle konu, etkileşimin en fazla olduğu Göktürkler, Uygurlar ve Kırgızların müzik kültürleriyle sınırlandırılmıştır. Önce bu üç Türk kavminin müzik kültürleri hakkında bilgi verilmiştir. Çalışmanın devamında
Tang dönemi Çin müziği anlatılmış, adı geçen Tük kavimlerinin müziklerinin Çin müziğine etkisi üzerinde durulmuştur. Türk müziğinin etkisiyle Çin müziği; yeni müzik sistemlerinin oluştuğu, pek çok müzisyenin yetiştiği, yenilendiği, zenginleştiği bir döneme girmiştir. Bu dönemde beş tanesi Türk kültürüne ait müzikler olan On Müzik Türü oluşturulmuş; pek çok Türk kökenli müzisyen Çin’de ünlenmiş; İmparatorluk Müzik Akademisinde yeni müzik sistemleri hakkında eğitim verilmiş, yetiştirilen müzisyenlerin birçoğu saray orkestrasında görevlendirilmiş; yeni müzikler, müzik aletleri ve danslar halk arasında beğeni toplamış ve yayılmıştır.
Leveling Entrepreneurial Skills of Vocational Secondary School Students in Indonesia: Impact of Demographic Characteristics
Authors: Susantiningrum Susantiningrum , Siswandari Siswandari , Joyoatmojo Soetarno , Mafruhah Izza 
Published: April 2023

Context: This article aims to determine the entrepreneurial skills of Vocational Secondary School students after the implementation of a new curriculum that promotes entrepreneurship courses in Indonesia. The authors believe that after taking such courses, students will be able to generate entrepreneurial skills. This study also explores the effect of demographic characteristics on students' entrepreneurship skills level, especially with respect to gender, school, and family. Approach: This study used a quantitative approach, with data collected through a questionnaire with five variables, that is, leadership, reflective communication, risk-taking, creatively innovative, and future orientation. Data were collected from 463 students who had taken entrepreneurship subjects that were chosen randomly. Data were analyzed using linear regression. Findings: 52.22% of our respondents had a moderate score for entrepreneurial skills, this is not in accordance with the expected learning outcomes, there are students who have entrepreneurial skills at a high level. With respect to creative innovation, in particular, a majority (53.15%) had a low score and 4.1% had a very low score. Moreover, family had a significant and positive effect on all dependent variables (leadership scores, reflective communication scores, risk-taking scores, creatively innovative scores, future orientation scores, and overall entrepreneurial skills scores). School demographic characteristics had a significant positive effect on the value of future orientation. These results indicate that private schools tend to strengthen the level of reflective communicative scores. Conclusion: The entrepreneurial skills of most vocational students are middling. This indicates that entrepreneurship subjects at Vocational Secondary schools have not been able to achieve their expected learning outcomes or help students develop entrepreneurial skills at a high level. Thus, further research is needed to determine the causes behind the problem. Schools are expected to be able to establish harmonious relationships by involving families to support the improvement of an informal learning environment that supports the mastery of entrepreneurial skills of vocational students.
Attenuation of Hemodynamic Response to Laryngoscopy and Endotracheal Intubation with Two Different Doses of Labetalol in Controlled Hypertensive Patients
Authors: Sagarika Borah  , Bandana Mahanta  , Sushmita Borah  
Published: April 2023

BACKGROUND
In this study, we wanted to compare the efficacy of two different doses of Labetalol for controlling the hemodynamic responses to laryngoscopy and tracheal intubation under the same anaesthetic techniques in controlled hypertensive patients.

METHODS
This was a hospital-based prospective, randomized, and double-blinded study conducted among 96 patients who presented for a pre-anaesthetic check-up to the Department of Anaesthesiology and Critical Care, at Gauhati Medical College and Hospital, over a period of 1 year from 1st September 2021 to 31st August 2022 after obtaining clearance from the institutional ethics committee, and written informed consent from the study participants.

RESULTS
Intragroup comparison of mean SBP in patients receiving IV Labetalol 0. 15 mg/Kg and IV Labetalol 0. 3mg/Kg was statistically significant. In an intragroup comparison of mean DBP in patients receiving IV Labetalol 0. 15 mg/Kg, it was significant at 5 and 10 mins. In a comparison of changes in DBP and MAP at various predetermined time intervals i. e., at intubation, it was statistically significant. In an intragroup comparison of mean RPP in in patients receiving IV Labetalol 0. 3mg/Kg in comparison to the baseline, it was significant at 10 mins.

CONCLUSIONS
Both doses of IV Labetalol (0. 15 mg/Kg and 0. 3 mg/Kg), given 5 mins before endotracheal intubation are effective in attenuating the hemodynamic response to laryngoscopy and intubation in controlled hypertensive patients. In comparison to the IV Labetalol dose of 0. 15 mg/Kg, attenuation of hemodynamic response to laryngoscopy and endotracheal intubation was more in IV Labetalol 0. 3 mg/Kg.
IMPLEMENTASI PERJANJIAN PERBATASAN RI – RDTL DALAM UPAYA PENYELESAIAN MASALAH PERBATASAN (Studi Kasus di Kabupaten TTU – RI dengan Distrik Oecusse-RDTL)
Authors: KOLNE YAKOBUS 
Published: April 2023

Recent observation regarding the reality of people’s living in the border region of the Republic of Indonesia-Timor Leste revealed the facts that they are still facing many problems directly related to all aspects of life that requires the government to take action through the implementation of the state border treaty policy in accordance with the community desire and expectation for sa conducive environment to the life of the nation and the state. The purpose of this study were: 1) to describe the implementation of border treaty between Indonesia and Timor Leste in the resolution of border problems in the District of Oecusse, TTU and 2) to describe and interpret the factors supporting and inhibiting the implementation of the border agreement in resolving the border issues. The method of this study was descriptive qualitative approach. The informants in this study were: Deputy Governor of NTT, TTU Regent, TTU Vice Regent, head of the BPP of TTU and Pamtas RI- Timor Leste Task Force, selected by purposive technique. The study found that: First; communication dimension: (a) lack of community involvement in determining national boundaries; (b) discussion/dialogue with the community had not been maximally conducted; (c) there is requirement to improve existing products of bilateral agreements. Second; Resources dimensions: (1) poor coordination between the senior government and the local government; (2) bolstering up to build further discussion/dialogue between the two countries involving indigenous people had not been done as proposed by the local government ; (3) lack of supporting infrastructures available for the people in the border region; (4) Minimum budget capacity. Third; Bureaucratic structures: (1) lack of supervision for the institutions/implementing agencies; (2) officials in the senior level of government did not involve the Government in the lower /regional level and local communities in setting the boundaries. Fourth; Implemention disposition: (1) The occurrence of interest claims resulting disharmony of interests; (2) the existence of public ignorance on the outcomes of the policy. The Supporting factors were: the availability of law products; commitment between government and society; and the lineage similarity of border communities. The inhibiting factors, however, were: minimum budget capacity, very limited availability of infrastructures and lack of coordination. Thus, the proposed suggestions and recommendations were: a necessity for socialization to the public about the purposes and benefits of the policy set; a nnecessity for budget support and other facilities in the border region as a state gateway; a necessity for a clearly distributed tasks and authority, so that it may not cause sectoral egoism.
KENDALA INVESTASI DI ERA OTONOMI DAERAH (Studi Kasus Pembangunan Proyek PLTU di Kabupaten Batang)
Authors: ISMAIL ISA 
Published: April 2023

Research that was headlined investment in Regional Autonomy era ( case study constraint the construction of PLTU project in the Batang Regency) is done using analysis of Pustaka about the concept of investment and the concept of regional autonomy. The study is done with the methodology of some research qualitative descriptive with purposive of sampling techniques in determining an informer and continues to be a snowball of sampling. Obtained data in field indicates that central program of government included in the program Master Plan for Acceleration and Expansion of Indonesia's Economic Development (MP3EI). The program of PLTU in Batang Regency worth more or less 38 trillion. Realization of PLTU project development was delayed for two years since the early planning. The delay of PLTU project has several problems, among others, such as lack of coordination between the central government and local governments, investors, a policy that overlap related regulations of marine conservation issued by regent, and the land acquisition process experiencing self denial of the owner of the land. Attempt completion constraint is still done through personal approaches between the local Government to the Government of the village, between the Government of the village with its citizens, especially the owner of the land where the project will be built and efforts in corporate social responsibility (CSR) by the investors realization with the construction of various public facilities to affected communities
Sharp inequalities for coherent states and their optimizers
Authors: Frank Rupert L. 
Published: April 2023

Abstract
We are interested in sharp functional inequalities for the coherent state transform related to the Wehrl conjecture and its generalizations. This conjecture was settled by Lieb in the case of the Heisenberg group, Lieb and Solovej for SU(2), and Kulikov for SU(1, 1) and the affine group. In this article, we give alternative proofs and characterize, for the first time, the optimizers in the general case. We also extend the recent Faber-Krahn-type inequality for Heisenberg coherent states, due to Nicola and Tilli, to the SU(2) and SU(1, 1) cases. Finally, we prove a family of reverse Hölder inequalities for polynomials, conjectured by Bodmann.