bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prise en charge thérapeutique de l’arthrose chez le chat
Authors: Decambron Adeline 
Published: June 2023

L’arthrose est une maladie incurable. De ce fait, on ne peut pas à proprement parler de traitement. Les objectifs de sa prise en charge sont de limiter la progression des lésions, la dégradation, l’inflammation et la douleur induite en permettant de rétablir une qualité de vie optimale pour l’animal. Le traitement de la douleur et de l’arthrose commence toujours par une évaluation. Il n’existe pas de traitement idéal et constant contre l’arthrose du chat, une approche multimodale et personnalisée basée sur l’analyse des bénéfices-risques pour l’animal est toujours nécessaire. Cette recommandation a pour principal intérêt de mettre l’accent sur l’importance de l’activité physique, du contrôle du poids et du bien-être et non pas de privilégier uniquement les médicaments. Notre arsenal thérapeutique (AINS, gabapentine, tramadol, amantadine, anticorps anti-NGF) s’est bien enrichi ces dernières années permettant d’adapter le traitement au chat et ses contraintes (environnement, comportement, comorbidités telles que la MRC, coûts). Le plus grand défi tient au fait que la douleur a des causes et mécanismes multiples. C’est pourquoi les choix thérapeutiques sont principalement basés sur une approche par essai-erreur (durée de traitement > 1 mois) en mesurant la réponse au traitement (CMI très utile) et en contrôlant la tolérance au traitement.
Gewichtszunahme nach Brustkrebsdiagnose – ein noch
unterschätztes Phänomen?
Authors: Colatruglio Alessia , Theobald Steffen 
Published: June 2023

Zusammenfassung
Ziel Die Gewichtszunahme bei Brustkrebspatientinnen ist ein bekannter
Nebeneffekt von Chemo- und endokriner Therapie, welche das Risiko für
die Gesamt- und brustkrebsspezifische Mortalität von
Brustkrebspatientinnen (BKP) erhöht, die psychosoziale Gesundheit
gefährdet und deshalb möglichst vermieden/ behandelt
werden sollte. Hierzu können Ernährungsinterventionen einen
wirksamen Beitrag leisten. Diese Arbeit untersucht, wie sensibilisiert
Onkologinnen und Onkologen (ONKO) für das Phänomen sind, wie sie
bei Gewichtszunahme von BKP vorgehen und welche Rolle die Zusammenarbeit mit
Ernährungsfachpersonen dabei spielt.
Methode Sieben auf gynäkologische Krebserkrankungen spezialisierte
ONKO wurden anhand eines halbstrukturierten Interviewleitfadens interviewt. Die
Datenanalyse erfolgte anhand einer qualitativ strukturierenden
Inhaltsanalyse.
Ergebnisse Vier Hauptkategorien konnten identifiziert werden, welche die
unterschiedlichen Sicht- und Handlungsweisen der ONKO bezüglich der
Gewichtszunahme bei BKP nach Diagnosestellung strukturieren: 1. Das
Phänomen: Beobachtung und Folgen einer Gewichtszunahme; 2.
Patientinnenbezogene Perspektivenübernahme bezüglich der
Gewichtszunahme; 3. Maßnahmen gegen eine Gewichtszunahme bei BKP; 4.
Maßnahmenleitende/-hemmende Gedanken bei einer
Gewichtszunahme.
Diskussion Die Handlungsweisen der ONKO (ungenügende
Maßnahmen zur Prävention und Behandlung einer Gewichtszunahme
bei BKP, seltene interprofessionelle Zusammenarbeit mit
Ernährungsfachpersonen) lassen sich durch ihre Sichtweisen
erklären: ONKO unterschätzen tendenziell: 1) die gesundheitliche
Relevanz der Gewichtszunahme, 2) die für BKP subjektive Relevanz der
Gewichtszunahme, 3) die fachliche Kompetenz von Ernährungsfachpersonen
sowie 4) die Wirksamkeit von Ernährungsinterventionen.
Schlussfolgerung Zur Förderung der Intention von ONKO,
Maßnahmen gegen eine Gewichtszunahme zu treffen, sollten ihre
Risikowahrnehmung (bezüglich gesundheitlicher Folgen einer
Gewichtszunahme) sowie ihre Handlungsergebniserwartung (bezüglich
Zusammenarbeit mit Ernährungsfachpersonen) erhöht werden.
Kurmäßige Anwendung von Radon bei muskuloskelettalen Erkrankungen
Authors: Resch Karl-Ludwig , Sommer Silvia 
Published: June 2023

ZUSAMMENFASSUNGPraktische Erfahrungen zum therapeutischen Einsatz des radioaktiven Edelgases Radon (Halbwertszeit knapp 4 Tage) in Kurorten gehen zurück bis in die Anfänge des 20. Jahrhunderts, als der deutsche Physiker Friedrich Ernst Dorn das Gas entdeckte und als „Radium Emanation“ beschrieb. Eine typische Radonkur besteht aus einer Serie von ca. 10 bis 15 etwa halbstündigen Expositionen in einem Radonvollbad bzw. einem Radoninhalationsraum, ggf. ergänzt durch die Ingestion geringer Mengen im Rahmen einer Radontrinkkur. Nach Resorption über die Haut oder Aufnahme über Lunge bzw. Darm wird Radon, das als Edelgas chemisch inert ist, beim ersten Passieren der Lunge weitestgehend wieder abgeatmet.Durch Studien gut belegt sind die lokalen Wirkungen einzelner Alpha-Zerfälle auf Zellen in der unmittelbaren Umgebung (Reichweite von Alpha-Teilchen: ca. 1 mm), insbesondere auf sog. dendritische Zellen des Immunsystems in der Haut (Langerhans-Zellen), im Darm und in der Lunge. Typischerweise wirken dendritische Zellen modulierend auf viele andere zelluläre Komponenten des Immunsystems im Sinne einer Dämpfung überschießender (Auto-)Immunreaktionen. Wissenschaftlich am besten untersucht (durch randomisiert kontrollierte Studien) sind die Wirkungen von Radonkuren auf entzündliche und degenerative Erkrankungen des Bewegungsapparats, insbesondere Schmerz und Entzündung. Die positiven Wirkungen sind für Zeiträume bis zu einem Jahr nachweisbar. Empirisch teils über lange Zeiträume gut dokumentiert sind ähnliche Effekte bei anderen Störungen, bei denen einem (über-)aktivem Immunsystem wesentliche Bedeutung für die jeweilige Pathologie zukommt, nicht zuletzt auch bei Autoimmunerkrankungen.Die zusätzliche Strahlungsbelastung durch eine Radonkur liegt im Streubereich der natürlichen Strahlenexposition unterschiedlicher Regionen Deutschlands. Die jeweils quantitativ geringe Strahlendosis im Rahmen einer begrenzten Anzahl von kurzzeitigen Expositionen kann nicht mit den Wirkungen einer Dauerexposition verglichen werden, da intermittierende Reize ganz offensichtlich nicht dem im Strahlenschutz postulierten „linear no threshold“-Prinzip folgen, sondern, wie viele physiologische Variablen, dem sogenannten Hormesis-Prinzip (etwa vergleichbar dem Heuschnupfen vs. der Hyposensibilisierung mit dem gleichen Agens).Die wohldosierte kurmäßige Anwendung des Edelgases Radon in den verschiedenen Applikationsformen kann, richtig und kompetent eingesetzt, einen hohen Nutzen für Patienten generieren, dem offensichtlich kein entsprechend erhöhtes Risiko gegenübersteht.
Endocannabinoide als neue Behandlungsoption der
Chemotherapie-induzierten Neurotoxizität (CIPN)
Authors: Holzhauer Peter 
Published: June 2023

ZusammenfassungDer medizinische Fortschritt in der Onkologie ermöglicht bei
verschiedenen Tumorentitäten die Durchführung von
medikamentösen Tumortherapien in immer weiteren und späteren
Therapielinien. Das bedeutet, dass mehr unterschiedliche Zytostatika und moderne
zielgerichtete Therapien in Kombination oder sequentiell eingesetzt werden
können. Das bringt für die Patienten längere
Behandlungszeiten und im besten Fall auch längere
Überlebenszeiten mit sich. Die zweite Seite des Januskopfes konfrontiert
die Patienten aber mit teilweise neuen und nicht selten auch
ausgeprägten und langanhaltenden Nebenwirkungen. Im Spektrum der
unerwünschten Toxizität von medikamentöser Tumortherapie
ist die Chemotherapie-induzierte Polyneuropathie (CIPN) besonders
problematisch.Im Beitrag wird sowohl ein Überblick über die zur
Verfügung stehenden supportiven konventionellen Maßnahmen als
auch ein Blick auf erweiterte Supportivmaßnahmen aus dem Bereich der
Komplementärmedizin vorgestellt. Ein besonderer Fokus liegt dabei auf
der neuen und noch relativ unbekannten Behandlungsoption mit Endocannabinoiden
in Kombination mit verschiedenen antiinflammatorischen Fettsäuren.
The Impact of Isolated Increased Nuchal Translucency ≥95th Centile on Perinatal Outcome: A Prospective Cohort Study from a North Indian Genetic Center
Authors: Khatter Sangeeta , Lall Meena , Agrawal Shruti , Mahay Sunita Bijarnia , Dimri Nandita , Sharma Nidhish , Gujral Kanwal , Verma Ishwar C. , Puri Ratna D. 
Published: June 2023

Abstract
Objectives The aim of this study was to determine the chromosomal abnormalities and other adverse outcomes like miscarriages, intrauterine deaths, structural defects, and genetic syndromes in fetuses with increased nuchal translucency (NT) more than or equal to 95th centile. This study also compared the outcomes in fetuses with NT between 95th and 99th centile and more than 99th centile.
Study Design A prospective cohort of 182 patients with isolated increased NT was evaluated by invasive testing. Fetal chromosomes were examined by fluorescent in situ hybridization and karyotype or chromosomal microarray. Euploid pregnancies were followed-up with level II ultrasound and fetal echocardiography. For pregnancies progressing to delivery, the neonates were followed-up till the age of 3 months. Final outcome was reported as normal or abnormal. Collated data for perinatal outcomes was analyzed and compared between fetuses with NT 95th and 99th centile (group I) and NT more than 99th centile (group II).
Results Of the 202 patients recruited, 182 patients consented for invasive testing and chromosomal analysis. Of the 182 patients, group I (NT 95–99th centile) included 92 patients and group II 90 patients. Chromosomal abnormalities were present in 50 (27.4%), 14 (7.6%) in group I, and 36 (19.4%) in group II. Of the 132 euploid pregnancies, adverse outcomes were present in 22 (16%) fetuses, 7 (5.3%) in group I, and 15(11.7%) in group II. A normal outcome was present in 110 (60.4%) pregnancies of the 182 fetuses with NT more than or equal to 95th centile. Normal outcome observed in group I was 77.1% and in group II, it was 43.4%.
Conclusion An increased NT is associated with poor perinatal outcomes in 39.6% patients. Chromosomal analysis and follow-up for adverse outcome in fetuses with NT more than or equal to 95th centile is important to enable a take home neonatal rate of 60.4%. No pregnancy with increased NT should be discontinued without detailed fetal evaluation for genetic disorders, structural malformation, and fetal growth.
A new view on ‘Yilan Creole’
Authors: Tan Gan-ling 
Published: June 2023

Abstract
In multilingual Taiwan, a language variety spoken in I-Lan County of northeastern Taiwan has been dubbed ‘Yilan
Creole’ and analyzed as a creole by scholars because it contains features from Japanese and Austronesian languages. This article
revisits the question of whether it is indeed a creole. I scrutinize its sociohistorical background as well as aspects of its
lexicon and grammar, which I compare with those of Japanese and (Squliq) Atayal to provide a solid foundation for assessing its
creole status. I conclude that ‘Yilan Creole’ is by no means a creole.
Loading and Transportation Issues in Horses
Authors: Loftus Loni 
Published: June 2023

Abstract
Refusal to load into a trailer or horsebox is a commonly seen behaviour in equines and one which is experienced by laypersons and professionals alike. Transportation of equines is highlighted as a prevalent welfare problem facing UK equines during a recent study. Problems with loading and travelling may occur in any equine at any life stage and may appear as significant issues from the first performance or develop gradually over time, increasing in frequency and intensity of their performance. These issues are likely to be maintained or worsened by repeated exposure to the travelling process and the use of inappropriate methods to attempt to resolve them. Behaviourally these problems present in a variety of ways including signs of stress, displacement and high levels of negative arousal. To fully understand the motivation for the behaviours identified, it is important that social, biological, psychological and functional analyses of the behavioural performance should be considered. Within this, there is also the element of learning, which is a constant aspect of the antecedent, behaviour and consequence continuum. Treatment protocols for travelling related issues should be holistic in nature to address the environmental, social, biological and psychological elements of the behavioural response.

Information
© The Author 2023
Animal-assisted interventions (AAIs)in situ, relationship, and context: AAI as adjunct practice in healthcare and animal-informed education
Authors: Hanrahan Cassandra , Boulton Amberlee 
Published: June 2023

AbstractAnimal-assisted interventions (AAIs) include and promote multisensory and somatic experiences in therapeutic, educational, and activity-based contexts. Sensory experiences, however, for animal co-workers and others in AAI practice, including the spaces in which AAI takes place, need further exploration not only to facilitate formalized animal and client safety in place-based contexts, but also to illuminate future directions for improved non-anthropocentric ‘animal-informed’ AAI. In Canada, where there is no coordinated professional AAI sector or ‘industry’ as it is referred in the USA, AAI is not a harmonized adjunct health service. Availability is linked to the locations of professional health and allied practitioners with AAI training and interested individuals who sustain the voluntarism needed to provide AAIs that a typically funded in ad hoc and limited capacities. Compared to related fields, like veterinarian medicine and zoology, there remains in general more to be known about the ways AAI relates to larger service contexts and the types of interactions (if any) with other health and mental health service providers. This article explores AAI locales within the Canadian province of Nova Scotia to highlight the occupational experiences of practitioners and their animal-companions/co-workers (from the perspective of practitioners). Through interviews and animal-informed critical theory, this study finds AAI locales boast opportunities despite challenges to access and delivery. We elucidate AAI’s potential of becoming a guide for collective interspecies (companionable-) relations. Some AAI locales are underutilized or mismanaged, others remote, all with untapped potential to contribute to their communities through more diverse (e.g. interspecies) interprofessional service environments and as part of local economies. Leveraged proactively with AAI practitioners as educators for universal relational well-being, AAI could potentially transform therapeutic practice, ideally fostering novel identities beyond the unsustainable humanized and bounded self.
Xurography as a tool for fabrication of microfluidic devices
Authors: Shahriari Shadi , Patel Vinay , Selvaganapathy P Ravi 
Published: June 2023

Abstract
Microfluidic devices have been conventionally fabricated using traditional photolithography or through the use of soft lithography both of which require multiple complicated steps and a clean room setup. Xurography is an alternative rapid prototyping method which has been used to fabricate microfluidic devices in less than 20–30 minutes. The method is used to pattern two-dimensional pressure-sensitive adhesives, polymer sheets, and metal films using a cutting plotter and these layers are bonded together using methods including adhesive, thermal, and solvent bonding. This review discusses the working principle of xurography along with a critical analysis of parameters affecting the patterning process, various materials patterned using xurography, and their applications. Xurography can be used in the fabrication of microfluidic devices using four main approaches: making multiple layered devices, fabrication of micromolds, making masks, and integration of electrodes into microfluidic devices. We have also briefly discussed the bonding methods for assembling the two-dimensional patterned layers. Due to its simplicity and the ability to easily integrate multiple materials, xurography is likely to grow in prominence as a method for fabrication of microfluidic devices.
Nanofluidic gas/liquid switching utilizing a nanochannel open/close valve based on glass deformation
Authors: Sano Hiroki , Kazoe Yutaka , Morikawa Kyojiro , Kitamori Takehiko 
Published: June 2023

Abstract
There has been much progress in the field of nanofluidics, and novel applications, such as single-cell analysis, have been achieved. In such cases, controlling the location of the gas/liquid interface is vital and partial hydrophobic modification is frequently used to pin the position of this interface. However, because the fluid manipulating pressure in such devices is comparable to the Laplace pressure at the interface of approximately 0.1 MPa, the interface cannot be maintained stably. The present work demonstrates a method of controlling the gas/liquid interface using a hydrophobic nanochannel open/close valve. The high Laplace pressure at this valve (on the order of 1 MPa) fixes the location of the interface even during fluid manipulation. In addition, the interface can be moved at any time simply by closing the valve to generate an impulsive pressure higher than the Laplace pressure. A device incorporating this nanochannel open/close valve was fabricated, and the surface of the valve chamber was modified with hydrophobic molecules. Gas/liquid replacement in association with the operation of this valve was verified using microscopic observations. It was verified that this replacement was triggered by the valve operation, with a replacement time of 1.2 s. Using this process, gas/liquid switching can be performed when desired and this control method could expand the use of gas/liquid two-phase systems to realize further integration of chemical processes in nanofluidics.
A new method for remaining useful life prediction by implementing joint learning of sensor dynamic graph and spatio-temporal features
Authors: Lv Shuai , Liu Shujie 
Published: June 2023

Abstract
Accurate implementation of remaining useful life (RUL) prediction of equipment is essential for health management and maintenance decisions. Advances in sensing and big data technologies have provided the possibility for research on data-driven life prediction methods. However, the current RUL prediction methods still need to improve in utilizing multi-source information. The present techniques consider more the relationship between the temporal information and RUL prediction among the multi-source information and rarely target the research and exploitation of the potential connection between sensor networks and RUL. Therefore, this paper proposes a spatio-temporal feature extraction network based on the sensor dynamic graph: DST-GT model. The method extracts the unidirectional relationship between sensors from monitoring data to construct a dynamic spatio-temporal graph reflecting the sensor relationship. The DST-GT model uses graph convolution based on message selection (MSGCN) to model the spatial dependencies of sensors, and uses multi-scale gated temporal convolution module (MGTCN) to model the temporal dependencies in sensor state monitoring data. In this paper, graph learning, graph convolution and temporal convolution modules are jointly learned in an end-to-end framework. The results on two widely used datasets and comparisons with other methods demonstrate the accuracy and advancement of DST-GT networks for RUL prediction.
Performance enhancement of HfO2-based resistive random-access memory devices using ZnO nanoparticles
Authors: Byun Jun-Ho , Ko Woon-San , Kim Ki-Nam , Lee Do-Yeon , Kwon So-Yeon , Lee Hi-Deok , Lee Ga-Won 
Published: June 2023

Abstract
In this study, resistive random-access memory (ReRAM) devices with ZnO nanoparticles (NPs) are suggested to enhance performance and reduce variation in device switching parameters. The ZnO NPs are formed by annealing ZnO prepared via atomic layer deposition on HfO2, which is verified using transmission electron microscopy, x-ray diffraction pattern, and atomic force microscopy. The depth profile analysis of x-ray photoelectron spectroscopy shows that oxygen diffuses from HfO2 to ZnO NPs during annealing. This can be explained by the calculation results using density functional theory (DFT) where the formation energy of oxygen vacancies is reduced at the interface of ZnO NPs and HfO2 compared to single HfO2. The fabricated ZnO NPs ReRAM demonstrates reduced forming voltage, stable resistive switching behavior, and improved cycle-to-cycle uniformity in a high-resistance state.
MoSe2 nanosheets/SiNWs heterojunction-based photocathode for efficient photoelectrochemical water splitting applications
Authors: Rahul  , Sharma Sweta , Devi Pooja , Arora Sunil K 
Published: June 2023

Abstract
The efficiency of a photoelectrochemical (PEC) device is governed by the solar response of the photoelectrode and kinematics of the hydrogen evolution reaction (HER). In this study, we illustrate a simple and low-cost method for the fabrication of photocathode (PC) via spray coating of MoSe2 nanosheets (prepared by liquid exfoliation) on p-SiNWs (p-type Silicon nanowires (NWs) prepared using metal-assisted chemical etching technique) and studied their integration as a PC for photoelectrochemical-hydrogen evolution reaction performance. The colossal photocurrent density of the resultant p-SiNWs-MoSe2 PC is −14.56  mA cm−2 at −1.2 V, which is appreciably larger in comparison to the bare p-SiNWs. Moreover, the charge transfer resistance (R
ct) corresponding to the p-SiNWs-MoSe2 electrode is 339 Ω, which is about two orders of magnitudes lower than that of p-SiNWs is attributed to the high donor density of MoSe2 nanosheets. The improvement in PEC performance is attributed to the strain at the p-SiNWs-MoSe2 interface promoted charge separation and thus reduces the kinetic barrier in water splitting process and enhances the overall HER. These results open up a scalable and effective route for implementing solar-fuel conversion at a large scale.
Synthesis, thermal evolution and magnetic investigations of SBA-15 silica functionalized with anchored iron phosphonate molecules
Authors: Fedorchuk Andrii , Laskowska Magdalena , Cempura Grzegorz , Kruk Adam , Nowak Anna , Dulski Mateusz , Kac Malgorzata , Pastukh Oleksandr , Zieliński Piotr M , Kubacki Jerzy , Laskowski Łukasz 
Published: June 2023

Abstract
In the current work, we report on the synthesizing of a series of novel nanocomposite materials obtained by functionalizing the SBA-15 silica matrix with anchored iron phosphonate molecules and the following thermal treatment. The obtained results reveal the formation of a unique amorphic layer of Fe-based compounds on the surface of silica walls of SBA-15 channels as a result of the organic groups’ decomposition after moderate thermal treatment. Due to their unique structure, represented in an active Fe-containing amorphous coating spread over a large surface area, these materials are of great interest for their potential applications in fields such as catalysis, adsorption, and non-linear optics. The obtained materials remain amorphous, preserving the SBA-15 mesoporous structure up to temperatures of approximately 800 °C, after which the partial melting of the silica backbone is observed with the simultaneous formation of nanocrystals inside the newly-formed glassy mass. All obtained materials were characterized using such techniques as thermogravimetry, transmission and scanning electron microscopy combined with energy dispersive x-ray spectroscopy mapping, Raman spectroscopy, N2 sorption analysis, x-ray diffraction, x-ray photoelectron spectroscopy, Mössbauer spectroscopy, and SQUID measurements.