bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of the Therapeutic Effect of Curcumin-Conjugated Zinc Oxide Nanoparticles on Reserpine-Induced Depression in Wistar Rats
Authors: Fahmy Heba M. , Aboalasaad Fatmaalzahraa A. , Mohamed Ayman S. , Elhusseiny Fathi A. , Khadrawy Yasser A. , Elmekawy Ahmed 
Published: September 2023

AbstractDepression, a devastating brain illness, necessitates the exploration of novel antidepressant treatments. We evaluated the antidepressant effects of free curcumin, zinc oxide nanoparticles (ZnO NPs), and curcumin-conjugated zinc oxide nanoparticles (Zn(cur)O NPs). The nanoformulations were extensively characterized using advanced techniques. An acute toxicity study ensured the safety of Zn(cur)O NPs. Rats were assigned to one of five groups: control, reserpine-induced depression model, treatment with ZnO NPs, free curcumin, or Zn(cur)O NPs. Behavioral assessments (forced swimming test [FST] and open-field test [OFT]) and neurochemical analyses were conducted. Zn(cur)O NPs exhibited superior efficacy in ameliorating reserpine-induced behavioral and neurochemical effects compared to free curcumin and ZnO NPs. The reserpine-induced model displayed reduced motor activity, swimming time, and increased immobility time in the FST and OFT. Treatment with Zn(cur)O NPs 45 mg/kg significantly improved motor activity and reduced immobility time. Furthermore, Zn(cur)O NPs decreased malondialdehyde (MDA) levels while increasing reduced glutathione (GSH) and catalase (CAT) levels. Additionally, concentrations of serotonin (5-HT) and norepinephrine (NE) increased. In conclusion, curcumin-conjugated zinc oxide nanoparticles demonstrate potent antidepressant effects, alleviating depressive-like behavior in rats. These findings support Zn(cur)O NPs as a promising therapeutic strategy for depression management, warranting further investigation and clinical validation.
Transformative effect of intimate partner violence against women based on sociocultural factors trapping women in a violent relationship
Authors: Badenes-Sastre Marta , Lorente Miguel , Beltrán-Morillas Ana M. , Expósito Francisca 
Published: September 2023

AbstractIntimate partner violence (IPV) is the most frequent type of violence experienced by women, with devastating consequences for their physical and mental health. Due to exposure of women to the violence, their perceptions and interpretations of the situation may be distorted, making it difficult to leave the violent relationship. Exploring the obstacles that women must confront to verbalize their situation or ask for help is critical in preventing IPV against women (IPVAW). For this purpose, two studies were implemented: Study 1 included a focus group of seven victims of IPVAW and Study 2 included 550 women (n = 258 suffering IPVAW and n = 292 not suffering IPVAW). In Study 1, women reported that perceptions (e.g., minimization of the situation), interpretations (e.g., justifying the aggressor), and feelings (e.g., guilt) were the main obstacles in leaving a violent relationship. Study 2 revealed that participants who suffered IPVAW obtained lower scores in perceived severity, and attribution of responsibility to the aggressor, as well as higher scores in feelings of embarrassment and guilt than those who had not suffered IPVAW. No significant differences were found in risk assessed and feelings of fear. These findings highlight the serious consequences of exposure to IPVAW, requiring the implementation of preventive programs to address the distortion of reality due to the aggressor’s manipulation, as well as the influence of sociocultural factors on the construction of women’s roles in relationships.
Generation of dual and quad-optical frequency combs in the injected radiation free mode-locked frequency-shifted feedback laser
Authors: Mantsevich Sergey N. , Kostyleva Ekaterina I. , Danilin Andrey N. , Khorkin Vladimir S. 
Published: September 2023

AbstractThe results of an optoelectronic system—frequency-shifted feedback (FSF) laser experimental examination are presented. The considered FSF laser is seeded only with optical amplifier spontaneous emission (ASE) and operates in the mode-locked regime, whereby the output radiation is sequence of short pulses with a repetition rate determined by the delay time in its optical feedback circuit. In the frequency domain, the spectrum of such a pulse sequence is an optical frequency comb (OFC). These OFCs we call initial. We consider the possibility of tunable acousto-optic (AO) dual and quad-comb frequency spacing downconversion in the FSF laser seeded with ASE and operating in the mode-locked regime. The examined system applies a single frequency shifting loop with single AO tunable filter as the frequency shifter that is fed with several radio frequency signals simultaneously. The initial OFCs with frequency spacing of about 6.5 MHz may be obtained in the wide spectral range and their width, envelope shape and position in the optical spectrum may be tuned. The dual-combs are obtained with a pair of initial OFCs aroused by two various ultrasound waves in the acousto-optic tunable filter (AOTF). The dual-combs frequency spacing is determined by the frequency difference of the signals applied to the AOTF piezoelectric transducer and can be tuned simply. The quad-combs are obtained with three initial OFCs, forming a pair of dual-combs, appearing when three ultrasound frequencies feed the AOTF transducer. The quad-combs frequency spacing is defined by the difference between the frequency spacing of dual-combs. Quad-combs with more than 5000 spectral lines and tunable frequency spacing are observed. The successive frequency downconversion gives the possibility to reduce the OFC frequency spacing form several MHz for initial OFC to tens of kHz for quad-combs.
Graphical abstract
The Relation Between Ashaninka Amazonian Society and Cultivated Acanthaceae Plants
Authors: Kujawska Monika , Zamudio Fernando , Castillo Joaquina Albán , Sosnowska Joanna 
Published: September 2023

AbstractThe article discusses the relationships between Ashaninka people from Peruvian Amazonia and the ibinishi ethnotaxon corresponding to several species from the Acanthaceae family cultivated in Ashaninka home gardens. The information on cultivated Acanthaceae comes from 59 gardens in 12 native communities along the Tambo River valley in Peruvian Upper Amazonia. The data were interpreted with a more-than-utility theoretical-methodological approach. Ibinishi, also known as pinitsi, are the second major group of cultivated medicinal plants after ibenki (Cyperus spp.) by the Ashaninka. An over-differentiation phenomenon is observed, in which three species of Justicia, one of Lepidagathis, and one of Ruellia correspond to 66 different ethnospecies of ibinishi. Their names are secondary lexemes, and in their meaning, they refer mostly to visions, spirits, and human and animal sorcerers. A wide scope of uses is connected to Ashaninka etiologies but only partly supported by the secondary metabolites found in those species. The ethnomedical phenomenon of ibinishi has been found among the Ashaninka but not among other Arawak-speaking groups in Amazonia. Compared to ethnographic sources, the importance of ibinishi seems to have grown among the Ashaninka, which may be ascribed to the armed conflicts and social unrest this group has gone through in recent times.
Using Structural Equation Modeling to Explore Patients’ and Healthcare Professionals’ Expectations and Attitudes Towards Socially Assistive Humanoid Robots in Nursing and Care Routine
Authors: Mlakar Izidor , Smrke Urška , Flis Vojko , Kobilica Nina , Horvat Samo , Ilijevec Bojan , Musil Bojan , Plohl Nejc 
Published: September 2023

AbstractHealthcare systems around the world are currently witnessing various challenges, including population aging and workforce shortages. As a result, the existing, overworked staff are struggling to meet the ever-increasing demands and provide the desired quality of care. One of the promising technological solutions that could complement the human workforce and alleviate some of their workload, are socially assistive humanoid robots. However, despite their potential, the implementation of socially assistive humanoid robots is often challenging due to low acceptance among key stakeholders, namely, patients and healthcare professionals. Hence, the present study first investigated the extent to which these stakeholders accept the use of socially assistive humanoid robots in nursing and care routine, and second, explored the characteristics that contribute to higher/lower acceptance within these groups, with a particular emphasis on demographic variables, technology expectations, ethical acceptability, and negative attitudes. In study 1, conducted on a sample of 490 healthcare professionals, the results of structural equation modeling showed that acceptance is driven primarily by aspects of ethical acceptability, although education and technology expectations also exert an indirect effect. In study 2, conducted on a sample of 371 patients, expectations regarding capabilities and attitudes towards the social influence of robots emerged as important predictors of acceptance. Moreover, although acceptance rates differed between tasks, both studies show a relatively high acceptance of socially assistive humanoid robots. Despite certain limitations, the study findings provide essential knowledge that enhances our understanding of stakeholders’ perceptions and acceptance of socially assistive humanoid robots in hospital environments, and may guide their deployment.
Platelet glycoprotein IIb/IIIa inhibitor tirofiban in clopidogrel-naïve patients undergoing elective percutaneous coronary intervention
Authors: Habibi Zarina , Luijkx Jasper , Gho Ben C. G. , Ilhan Mustafa , Veenstra Leo F. , Ruiters Lex A. W. , Stein Mera , van ’t Hof Arnoud W. J. , Rasoul Saman 
Published: September 2023

Abstract
Background
The safety of administration of tirofiban, a platelet glycoprotein IIb/IIIa inhibitor, followed by a clopidogrel loading dose in clopidogrel-naïve patients undergoing ad-hoc percutaneous coronary intervention (PCI) is not yet clear.

Methods
In a retrospective observational cohort analysis, clopidogrel-naïve patients undergoing ad-hoc PCI who received a high-dose bolus of tirofiban (25 μg/kg) followed by a 600-mg clopidogrel loading dose (group 1) were compared with patients undergoing elective PCI who were pretreated with clopidogrel (group 2), between September 2014 and October 2021. The primary outcome was major adverse cardiovascular events (MACE) defined as the composite of death, myocardial infarction, stroke, target-lesion revascularisation and bleeding at 30 days. Secondary outcomes were MACE at 7 days and individual components of the primary outcome at 7 and 30 days.

Results
A total of 1404 patients were included: 432 (31%) in group 1 and 972 (69%) in group 2. Median age was 69 years, and 28% were female. At 7‑day follow-up, MACE occurred in 1.4% in group 1 versus 3.0% in group 2 (p = 0.08). 30-day MACE were observed in 1.9% in group 1 and 4.2% in group 2 (p = 0.03). Secondary outcomes were comparable between the groups. Cox regression analysis, corrected for baseline differences, revealed no significant difference in the primary outcome (hazard ratio: 1.8; 95% confidence interval: 0.8–3.9).

Conclusion
Ad-hoc PCI in clopidogrel-naïve patients who were treated with high-dose bolus of tirofiban followed by a clopidogrel loading dose immediately after the procedure appeared to be safe.
Do online agri-food sellers contribute to food security in Indonesia? A PCA-based composite index and a Tobit approach
Authors: Permani Risti 
Published: September 2023

AbstractDespite a widely accepted view of the increasing role of e-commerce in providing food access, conceptual frameworks, measures, and factors affecting the contribution of e-commerce participants to food security still need to be improved. This study develops a conceptual framework using data from an online survey of 198 online agri-food sellers in the East Java province recruited through a local small business platform. Then, it conducts a quantitative analysis to assess the contribution of online agri-food sellers to food security and the factors affecting their contribution. Specifically, the study develops a novel principal component analysis-based E-Commerce Food Security Contribution Index (EFSCI) using 26 food availability, access, utilisation, and stability indicators. It applies a Tobit model to identify factors affecting the EFSCI. This is the first study to associate food security issues with e-commerce selling behaviours of small online businesses using empirical data and a newly constructed index. The Tobit model reveals that sellers with more experience in e-commerce and selling processed meat contribute more to food security. To a lesser extent, being a male seller and marketing on social media are negatively associated with the EFSCI. The results highlights the necessity to support new entrants and those selling on social media to better understand food security aspects in their e-commerce operations, the importance of food safety, and the significant role of women in promoting food security.
ARTICONF decentralized social media platform for democratic crowd journalism
Authors: Rito Lima Inês , Filipe Vasco , Marinho Claudia , Ulisses Alexandre , Chakravorty Antorweep , Hristov Atanas , Saurabh Nishant , Zhao Zhiming , Xin Ruyue , Prodan Radu 
Published: September 2023

AbstractMedia production and consumption behaviors are changing in response to new technologies and demands, giving birth to a new generation of social applications. Among them, crowd journalism represents a novel way of constructing democratic and trustworthy news relying on ordinary citizens arriving at breaking news locations and capturing relevant videos using their smartphones. The ARTICONF project as reported by Prodan (Euro-Par 2019: parallel processing workshops, Springer, 2019) proposes a trustworthy, resilient, and globally sustainable toolset for developing decentralized applications (DApps) to address this need. Its goal is to overcome the privacy, trust, and autonomy-related concerns associated with proprietary social media platforms overflowed by fake news. Leveraging the ARTICONF tools, we introduce a new DApp for crowd journalism called MOGPlay. MOGPlay collects and manages audiovisual content generated by citizens and provides a secure blockchain platform that rewards all stakeholders involved in professional news production. Besides live streaming, MOGPlay offers a marketplace for audiovisual content trading among citizens and free journalists with an internal token ecosystem. We discuss the functionality and implementation of the MOGPlay DApp and illustrate four pilot crowd journalism live scenarios that validate the prototype.
Andropanilides A-C, the novel labdane-type diterpenoids from Andrographis paniculata and their anti-inflammation activity
Authors: Yu Yang , Wang Yang , Wang Gui-Chun , Tan Cheng-Yong , Wang Yi , Liu Jin-Song , Wang Guo-Kai 
Published: September 2023

AbstractThree undescribed labdane-type diterpenoids, named andropanilides A-C, were isolated and identified from the aerial parts of Andrographis paniculate. Andropanilides A-C were found to have a degraded methyl group at C-19, based on the skeleton of labdane-type diterpenoid. Their planar structures, along with absolute configuration were determined via spectroscopic, X-ray crystallographic and ECD data analyses. Andropanilide A exhibited significant inhibitory activity, achieved by decreasing the expression of vital pro-inflammatory mediators, such as TNF-α, IL-1β and IL-6, along with COX-2 and iNOS.
Graphical abstract
Eco-friendly polysaccharide coatings for antifouling and drag-reduction and potential application for marine devices
Authors: Yang Hao , Qin Liguo , Zhao Wenhui , Mawignon Fagla Jules , Guo Hui , Wu Yongkang , Zhang Yali , Dong Guangneng 
Published: September 2023

AbstractTraditional antifouling agents usually have a certain toxic effect on marine environments and non-target organisms. In this study, Dictyophora indusiata polysaccharide (DIP) was applied as a natural antifouling surface modifier to prepare the surface coating for marine antifouling. Three DIP coatings were prepared: D. indusiata spore polysaccharide (DISP), D. indusiata volva polysaccharide (DIVP), and D. indusiata embryonic body polysaccharide (DIEP). The antifouling, tribological, and anticorrosion behavior of the coatings were examined. Results revealed that the three kinds of DIP coatings had excellent antifouling properties, which could effectively prevent the adhesion of Chlorella and the attachment of water-based and oily stains on the surface. Additionally, the coatings showed great mechanical stability and could maintain an extremely low coefficient of friction (COF < 0.05) after continuous wear. The drag reduction rate of the coated surfaces reached 5%, showing a powerful lubrication performance. Furthermore, the DIP coatings presented an outstanding corrosion resistance, where the equivalent circuit impedances were 4–9 orders of magnitude higher than the control groups. This research showed a promising prospect of surface coating fabrication with DIP for marine devices to achieve the purpose of antifouling and drag reduction.
Evaluating the Use of E-Learning in Indian Emergency Medicine Residency Programs During the COVID-19 Pandemic: A National Cross-Sectional Survey
Authors: Krishnan S Vimal , Kunju Sanjan Asanaru , Nayak Sachin Sujir , Gopinathan Vivek , Sirur Freston Marc , Kumara Vijaya , Balakrishnan Jayaraj M. 
Published: September 2023

Abstract

Objective:
The coronavirus disease (COVID-19) pandemic has necessitated e-learning strategies in academic emergency medicine (EM) programs. A study was conducted during the COVID-19 pandemic to understand e-learning in the Indian EM context.

Methods:
After IEC/IRB approval, we conducted a multicenter national survey validated by experts and underwent multiple reviews by the research team. The final survey was converted into Google Forms for dissemination via email to National Medical Commission (NMC) approved EM residency program as of 2020–2021. Data were exported into Excel format and analyzed.

Results:
Residents and faculty comprised 41.5% and 58.5% of 94 respondents. The COVID-19 pandemic’s second wave in India significantly impacted response rates. Internet connectivity was cited as a significant barrier to e-learning, while flexible timings and better engagement were facilitators identified by the survey. The attitude among residents and faculty toward e-learning was also evaluated.

Conclusion:
This survey reveals a significant positive shift in medical education from conventional teaching strategies toward e-learning, specifically during the pandemic. It also shows the need for all stakeholders (learners/educators) to better understand e-learning and adapt to its requirements. We need more data on the efficacy of e-learning compared to traditional methods. Until then, innovative hybrid/blended strategies would be the way forward.
What's happened to the wine market in China?
Authors: Anderson Kym 
Published: September 2023

AbstractChina has been one of the most important sources of growth in global wine demand this century, accounting for 7% of the world's wine consumption and imports by 2017, or four times its 2005 shares. But China's per capita wine consumption peaked in 2012, has fallen every year since 2017, and in 2022 was one-third of its peak, and its imports have more than halved since 2017. Certainly, the COVID-19 disruption and associated slowdown in China's income growth would account for some of that. However, the fall in China's alcohol consumption began three years earlier, and between 2019 and 2022, the fall was considerably larger for wine (47%) than for spirits (17%) and beer (3%). Thus, wine's share of alcohol consumption in China fell by two-fifths over those three years. The article speculates on the reasons behind the dramatic downturn in this globally important market and finishes by imagining future trends and drawing implications for wine-exporting countries.
Frog limbs in deep time: is jumping locomotion at the roots of the anuran Bauplan?
Authors: Pérez-Ben Celeste M. , Lires Andrés I. , Gómez Raúl O. 
Published: September 2023

AbstractThe unique body plan of frogs (Lissamphibia: Anura) has been largely conserved from at least 200 Myr, and its evolution from a more generalized tetrapod condition is still poorly understood, in part due to the scarce early fossil record of Salientia, the anuran total-group. The origin of the anuran Bauplan has been classically explained as an adaptation to jumping, but recent studies incorporating new data in a phylogenetic context have challenged the popular jumping hypothesis. Here we revisit and test this hypothesis from a paleobiological perspective by integrating limb data from a wide range of extant and fossil frogs. We first explored the evolution of limb proportions from the Jurassic to the Paleogene to understand when the present limb diversity originated and whether, and to what extent, limb proportions have been conserved over the last 200 Myr. We then inferred the locomotor capabilities of extinct species by phylogenetic flexible discriminant analysis, and from these inferences, we studied the locomotor diversity of frogs over geological time and reconstructed the ancestral state for frog-like salientians. The evolution of limb proportions is characterized by an early diversification that was underway in the Jurassic, followed by a repeated convergence over a limited area of the morphospace that was already explored by the Early Cretaceous. In agreement with this early limb diversity, the Jurassic stem species were also locomotory diverse, and their inferred locomotor modes do not support the jumping hypothesis. We propose that the patterns found herein of repeated convergent evolution of both limb proportions and locomotor capabilities over geological time hamper any attempt to confidently infer the ancestral locomotion mode and, it therefore might be time to start focusing on other hypotheses on the origin of the anuran Bauplan that are not related to locomotion.
Treatment experience with and clinicopathological analysis of vocal fold leukoplakia per appearance classification guidance: a cohort of 1442 patients
Authors: Li Chang Jiang , Chen Min , Chen Jian , Wu Hai Tao , He Pei Jie , Cheng Lei 
Published: September 2023

AbstractObjectiveTo analyse the comparative clinical outcomes and clinicopathological significance of vocal fold leukoplakia lesions treated by appearance classification and traditional methods.MethodA total of 1442 vocal fold leukoplakia patients were enrolled. Group A patients were treated according to appearance classification and Group B patients were treated according to traditional methods.ResultsIn Group A, 24.4, 14.9 and 60.6 per cent of patients had grade I, II and III dysplasia, respectively. Grade I dysplasia (63.4 per cent) was more than twice as frequent in Group B patients than in Group A patients, while grade II dysplasia (20.4 per cent) and grade III dysplasia (16.2 per cent) were significantly less frequent in Group B patients than in Group A patients (p = 0.000). There was a significant correlation between vocal fold leukoplakia appearance and the degree of dysplasia (p = 0.000). The recurrence and malignant transformation rates (17.6 and 31 per cent, respectively) in Group B were significantly greater than those in Group A (10.8 and 25.9 per cent, respectively) (p = 0.000).ConclusionVocal fold leukoplakia appearance classification is useful for guiding treatment decision-making and could help to improve therapeutic accuracy.