bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improving diagnostic performance of rib fractures for the night shift in radiology department using a computer-aided diagnosis system based on deep learning: A clinical retrospective study
Authors: Xiong Shan , Hu Hai , Liu Sibin , Huang Yuanyi , Cheng Jianmin , Wan Bing 
Published: February 2023

OBJECTIVE: To investigate the application value of a computer-aided diagnosis (CAD) system based on deep learning (DL) of rib fractures for night shifts in radiology department. METHODS: Chest computed tomography (CT) images and structured reports were retrospectively selected from the picture archiving and communication system (PACS) for 2,332 blunt chest trauma patients. In all CT imaging examinations, two on-duty radiologists (radiologists I and II) completed reports using three different reading patterns namely, P1 = independent reading during the day shift; P2 = independent reading during the night shift; and P3 = reading with the aid of a CAD system as the concurrent reader during the night shift. The locations and types of rib fractures were documented for each reading. In this study, the reference standard for rib fractures was established by an expert group. Sensitivity and false positives per scan (FPS) were counted and compared among P1, P2, and P3. RESULTS: The reference standard verified 6,443 rib fractures in the 2,332 patients. The sensitivity of both radiologists decreased significantly in P2 compared to that in P1 (both p <  0.017). The sensitivities of both radiologists showed no statistical difference between P3 and P1 (both p >  0.017). Radiologist I’s FPS increased significantly in P2 compared to P1 ( p <  0.017). The FPS of radiologist I showed no statistically significant difference between P3 and P1 ( p >  0.017). The FPS of Radiologist II showed no statistical difference among all three reading patterns ( p >  0.05). CONCLUSIONS: DL-based CAD systems can be integrated into the workflow of radiology departments during the night shift to improve the diagnostic performance of CT rib fractures.
Antihypertensive Medications Adherence and Its Relationship to Blood Pressure Control Among Healthcare Workers in Jose R. Reyes Memorial Medical Center (JRRMMC): A Retrospective Analytic Study
Authors: Macalinao Divinilio , Marcos Joshua A. , Francisco Peter Julian 
Published: February 2023

BACKGROUND: Workers, including those in the healthcare industry, are exposed to occupational hazards that interfere with the health-disease process, negatively impacting their physical,[1] mental, and social health. [2] High blood pressure (HBP) is an important risk factor for cardiovascular disease and mortality of people in full productive capacity.[3] It is possible to assume that hypertensive patients who work in hospitals are more aware of the causes and complications related to hypertension, as well as about ways of prevention and treatment. Despite this assumption, there is a scarcity of studies looking at the level of adherence of Filipino healthcare workers in taking their antihypertensive medication OBJECTIVE: The study assessed antihypertensive treatment adherence and associated factors in healthcare workers from Jose R. Reyes Memorial Medical Center. METHODS: This is a retrospective analytic study design, consisting of 250 workers who self-reported as being hypertensive. Associations between sociodemographic, work, and health variables were assessed regarding adherence. The Morisky Medication Adherence Scale-8 (MMAS-8) was chosen for the study. RESULTS: Sixty % of participants were classified as controlled hypertensive patients, with 60% taking ARBs and 55.20% taking CCBs; from these, 84.80% of workers adhered to medication treatment. Adherence to pharmacological treatment has no significant association with BP control (p >.05). "Missing medical appointments" presented a statistically significant association with non-adherence to treatment. There was a greater chance (OR=5.85; p=0.005) of professionals who missed medical appointments not adhering to treatment, compared to those who reported not missing them. CONCLUSIONS: The main factors for non-adherence to treatment by workers were the presence of antihypertensive treatment disruption and missing medical appointments. Since hypertension and other cardiovascular diseases are asymptomatic diseases that require continuous treatment, hypertensive patients have difficulties understanding the importance of adhering to treatment.
Persepsi tentang Faktor yang Mempengaruhi Perilaku Kepatuhan pada Klien Hipertensi
Authors: Wibrata Dwi Ananto , Fadilah Nikmatul , Wijayanti Dyah , Kholifah Siti Nur 
Published: February 2023

Abstrak
Perawatan hipertensi memerlukan jangka waktu yang panjang. Faktor perilaku kepatuhan klien merupakan komponen penting dalam keberlanjutan perawatan. Tujuan dari penelitian ini adalah mengidentifikasi persepsi tentang faktor yang mempengaruhi perilaku kepatuhan klien hipertensi. Penelitian ini menggunakan pendekatan kualitatif dengan studi fenomenologi. Teknik pengumpulan data menggunakan wawancara dan observasi. Jumlah partisipan 20 penderita hipertensi di wilayah kerja Puskesmas Krembangan Selatan Surabaya. Keabsahan data menggunakan triangulasi sumber data. Hasil penelitian menemukan empat tema yaitu kepercayaan diri, penerimaan diri, dukungan keluarga, ketersediaan informasi. Kesimpulan penelitian ini adalah kemampuan mengambil keputusan pada klien, penerimaan klien hipertensi terhadap penyakitnya, dukungan dari keluarga dan tersedianya informasi yang sangat memadai mempengaruhi kepatuhan perawatan klien hipertensi. Keluarga perlu memberikan kapasitas pada klien untuk mengambil keputusan dan menfasilitasi kebutuhannya. Keluarga juga sebagai sumber informasi perlu meningkatkan pemahaman tentang perawatan hipertensi.
Kata kunci: persepsi, perilaku merawat diri, hipertensi

Abstract
Treatment of hypertension requires a long period of time. The client's compliance behaviour factor is an important component in the continuity of care. The purpose of this study was to identify perceptions of factors that influence the compliance behavior of hypertension clients. This study used a qualitative approach with a phenomenological study. The number of participants is 20 people with hypertension in the working area of the Krembangan Selatan Health Center. Data collection techniques used interviews and observations. The validity of the data used triangulation of data sources. The results found 4 themes, namely self-confidence, self-acceptance, family support, availability of information. The conclusion of this research is the ability to make decisions on the client, the client's acceptance of hypertension for their disease, support from the family and the availability of adequate information affect the adherence to care for hypertensive clients. Families need to give the client the capacity to make decisions and facilitate their needs. Families as well as sources of information need to increase understanding of hypertension treatment.
Keywords: perception, self-care behavior, hypertension
Uncertainty of Disease Process with Self Empowerment in Hypertension Patients
Authors: Kustin Kustin , Budiman M. Elyas Arif , Silvanasari Irwina Angelia , Putri Adinda Oktavia 
Published: February 2023

Abstrak
Ketidakpastian proses penyakit hipertensi menyebabkan stres karena ketidakpastian di sekitar penyakit, proses penyakit, pengobatan dan efek samping. Ketidakpastian ini disebabkan karena self empowerment yang buruk. Strategi self empowerment dikembangkan pada penyakit hipertensi untuk meningkatkan kontrol mereka terhadap penyakitnya dan meningkatkan kesehatan mental yang lebih baik dan sejahtera. Tujuan penelitian ini untuk mengetahui hubungan ketidakpastian proses penyakit dengan self empowerment pada pasien hipertensi di Klinik Silo Sehat Kabupaten Jember. Metode penelitian ini adalah cross-sectional dengan jumlah sampel dalam penelitian ini adalah 58 pasien penderita hipertensi diambil dengan teknik simple random sampling. Alat ukur yang digunakan pada variabel self empowertment menggunakan self empowerment questionnaire dan variabel ketidakpastian menggunakan kuesioner Uncertainty in Illness questionnaire dengan analisis data menggunakan contingency coefficient. Hasil analisis dengan uji contingency coefficient pada α=0,05 didapat p-value 0,00 < α (0,05) sehingga dapat diambil kesimpulan bahwa terdapat hubungan ketidakpastian proses penyakit dengan self empowerment pada pasien hipertensi. Self empowerment dapat menurunkan ketidakpastian (uncertainty) dan dapat meningkatkan adaptasi psikososial sehingga sangat perlu bagi klien hipertensi dalam menangani potensi stressor dan ketidakpastian proses penyakit hipertensi.
Kata kunci: hipertensi, ketidakpastian, self empowerment

Abstract
The uncertainty of the hypertension disease process causes stress because of the uncertainty surrounding the disease, the disease process, treatment, and side effects. The uncertainty was caused by bad self empowerment. The self-empowerment strategies for hypertension patients were developed in order to improve disease control and promote better mental health and well-being. The purpose of this study was to determine the relationship between uncertainty of the disease process and self empowerment in hypertension patients at Silo Sehat Clinic, Jember. This research method was cross-sectional with the number of samples in this study were 58 patients with hypertension taken by simple random sampling technique. The measuring instrument used for the self empowerment variable is the self empowerment questionnaire and the uncertainty variable is the MUIS/Mishel Uncertainty in illness questionnaire. In this study, data analysis was performed using the contingency coefficient. The results of the analysis using the contingency coefficient test 0.05 obtained p-value (0.00 (0.05), indicating that there is a relationship between disease process uncertainty and self empowerment in hypertension patients. With sufficient self empowerment, the information about the disease obtained from health workers was quite good and helped clients in dealing with potential stressors and increasing self empowerment.
Keywords: hypertension, uncertainty, self empowerment
Evaluating the Cyclic Behavior of the Sloped Extended End-plate Beam-to-column Connections
Authors: Miryahyavi Mirreza , Khani Reza , Hosseinzadeh Yousef 
Published: February 2023

In the Northridge and Kobe earthquakes, brittle failure of the welded beam-to-column connections was observed in steel structures. So, bolted connections were considered as an alternative to these kinds of connections. Extended end-plate beam-to-column con-nection is one of the most commonly used connections in steel structure. In this article, the behavior of the sloped extended end-plate beam-to-column connections is studied. Finite element method was used to investigate the behavior of the connection by ABAQUS software. The main aim of the study was to investigate the cyclic behavior of the four beam-to-column connections with beam angles of 0, 10, 15, and 20 degrees with respect to horizon. Also, the behavior of the mentioned connections was compared with extended end-plate connections with perpendicular angle. Results showed that the ductility and moment-resisting capacity of the sloped extended end-plate beam-to-column connections decrease by increasing beam angle, but rotational and moment-resisting capacities of the models satisfy the limitation of the design codes such as 0.04 drift limit for bearing capacity before failure.
The Effect of Layer Thickness and Orientation of the Workpiece on the Micro- and Macrogeometric Properties and the Machining Time of the Part during 3D Printing
Authors: Kónya Gábor , Ficzere Péter 
Published: February 2023

3D printing technologies have developed significantly over the last 30 years, with a major impact on all segments of today's industry. With the introduction of additive manufacturing, product development time can be greatly reduced and printing functional parts directly is also a viable option. Another advantage of additive manufacturing is that it allows greater design freedom than traditional manufacturing technologies. This makes it possible to print products with complex geometries and even different material qualities. In this paper, the authors investigated the effects of printing time, the layer thickness and the orientation on the surface roughness and cylindricity of the printed parts. The aim is to find the combination of layer thickness and part orientation which causes the best results in terms of surface roughness and cylindricity as a function of printing time.
MicroRNA-21 mediated cross-talk between cardiomyocytes and fibroblasts in patients with atrial fibrillation
Authors: Pradhan Kabita , Niehues Paul , Neupane Balram , Maleck Carole , Sharif-Yakan Ahmad , Emrani Mahdi , Zink Matthias Daniel , Napp Andreas , Marx Nikolaus , Gramlich Michael 
Published: February 2023

BackgroundAtrial fibrosis represents a major hallmark in disease progression of atrial fibrillation (AF). We have previously shown that circulating microRNA-21 (miR-21) correlates with the extent of left atrial fibrosis in patients undergoing catheter ablation for AF and can serve as a biomarker to predict ablation success. In this study, we aimed to validate the role of miR-21-5p as a biomarker in a large cohort of AF patients and to investigate its pathophysiological role in atrial remodeling.MethodsFor the validation cohort, we included 175 patients undergoing catheter ablation for AF. Bipolar voltage maps were obtained, circulating miR-21-5p was measured, and patients were followed-up for 12  months including ECG holter monitoring. AF was simulated by tachyarrhythmic pacing of cultured cardiomyocytes, the culture medium was transferred to fibroblast, and fibrosis pathways were analysed.Results73.3% of patients with no/minor LVAs, 51.4% of patients with moderate LVAs and only 18.2% of patients with extensive LVAs were in stable sinus rhythm (SR) 12  months after ablation (p &lt; 0.01). Circulating miR-21-5p levels significantly correlated with the extent of LVAs and event-free survival. In-vitro tachyarrhythmic pacing of HL-1 cardiomyocytes resulted in an increased miR-21-5p expression. Transfer of the culture medium to fibroblasts induced fibrosis pathways and collagen production. The HDAC1 inhibitor mocetinostat was found to inhibit atrial fibrosis development.ConclusionWe validated miR-21-5p as a biomarker that reflects the extent of left atrial fibrosis in AF patients. Furthermore, we found that miR-21-5p is released in-vitro from cardiomyocytes under tachyarrhythmic conditions and stimulates fibroblasts in a paracrine mode to induce collagen production.
A systematic review and meta-analysis of heart rate variability in COPD
Authors: Alqahtani Jaber S. , Aldhahir Abdulelah M. , Alghamdi Saeed M. , Al Ghamdi Shouq S. , AlDraiwiesh Ibrahim A. , Alsulayyim Abdullah S. , Alqahtani Abdullah S. , Alobaidi Nowaf Y. , Al Saikhan Lamia , AlRabeeah Saad M. , Alzahrani Eidan M. , Heubel Alessandro D. , Mendes Renata G. , Alqarni Abdullah A. , Alanazi Abdullah M. , Oyelade Tope 
Published: February 2023

BackgroundChronic obstructive pulmonary disease (COPD) is associated with disruption in autonomic nervous control of the heart rhythm. We present here quantitative evidence of the reduction in HRV measures as well as the challenges to clinical application of HRV in COPD clinics.MethodFollowing the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, we search in June 2022 Medline and Embase databases for studies reporting HRV in COPD patients using relevant medical subject headings (MeSH) terms. The quality of included studies was assessed using the modified version of the Newcastle–Ottawa Scale (NOS). Descriptive data were extracted, while standardized mean difference was computed for changes in HRV due to COPD. Leave-one-out sensitivity test was performed to assess exaggerated effect size and funnel plots to assess publication bias.ResultsThe databases search yielded 512 studies, of which we included 27 that met the inclusion criteria. The majority of the studies (73%) had a low risk of bias and included a total of 839 COPD patients. Although there were high between-studies heterogeneity, HRV time and frequency domains were significantly reduced in COPD patients compared with controls. Sensitivity test showed no exaggerated effect sizes and the funnel plot showed general low publication bias.ConclusionCOPD is associated with autonomic nervous dysfunction as measured by HRV. Both sympathetic and parasympathetic cardiac modulation were decreased, but there is still a predominance of sympathetic activity. There is high variability in the HRV measurement methodology, which affects clinical applicability.
NT-proBNP trajectory after transcatheter aortic valve replacement and its association with 5-year clinical outcomes
Authors: Zhou Yaoyao , Zhu Qifeng , Hu Po , Li Huajun , Lin Xinping , Liu Xianbao , Pu Zhaoxia , Wang Jian’an 
Published: February 2023

BackgroundThere are only limited reports on the trends of NT-proBNP after transcatheter aortic valve replacement (TAVR) in aortic stenosis (AS) and even fewer report on the prognostic value of the NT-proBNP trajectory following TAVR.ObjectivesThis study aims to investigate short-term NT-proBNP trajectory following TAVR and explore its association with clinical outcomes in TAVR recipients.MethodsAortic stenosis patients undergoing TAVR were included if they had NT-proBNP levels recorded at baseline, prior to discharge, and within 30 days after TAVR. We used latent class trajectory models to identify NT-proBNP trajectories based on their trends over time.ResultsThree distinct NT-proBNP trajectories were identified from 798 TAVR recipients, which were named class 1 (N = 661), class 2 (N = 102), and class 3 (N = 35). Compared to those with trajectory class 1, patients with trajectory class 2 had a more than 2.3-fold risk of 5-year all-cause death and 3.4-fold risk of cardiac death, while patients with trajectory class 3 had a more than 6.6-fold risk of all-cause death and 8.8-fold risk of cardiac death. By contrast, the groups had no differences in 5-year hospitalization rates. In multivariable analyses, the risk of 5-year all-cause mortality was significantly higher in patients with trajectory class 2 (HR 1.90, 95% CI 1.03–3.52, P = 0.04) and class 3 (HR 5.70, 95% CI 2.45–13.23, P &lt; 0.01).ConclusionOur findings implied different short-term evolution of NT-proBNP levels in TAVR recipients and its prognostic value for AS patients following TAVR. NT-proBNP trajectory may have further prognostic value, in addition to its baseline level. This may aid clinicians with regards to patient selection and risk prediction in TAVR recipients.
Study on surface-wave tomography in Abaga volcanic area, Inner Mongolia
Authors: Hou Jie , Wu Qingju , Yu Daxin , Ye Qingdong , Zhang Ruiqing 
Published: February 2023

In this paper, the 3-D S-wave velocity structure of the crust and upper mantle in the Abaga volcanic area of Inner Mongolia was inverted by using the surface-wave tomography method, with a resolution of 0.5°×0.5°. For the first time, the vertical continuous data recorded by 36 and 25 broadband mobile seismic stations in Abaga volcanic area from October 2012 to May 2015 (NM array) and October 2017 to October 2018 (AB array) were adopted together. The results showed that there was a significant high velocity anomaly structure in the upper mantle at 80–140 km depth in the Abaga volcanic area, and there was a significant low velocity anomaly structure above the high velocity anomaly, which reflected that lithospheric delamination may occurr in the Abaga volcanic area. The overlying NW-SE low-velocity anomaly extended northwest to the boundary of the study area, then to the South Gobi of the Mongolian Plateau; spread southeast to the crustal thinning area and the exposed position of the Abaga volcanic group on the surface. According to the analysis of previous research results, it speculated that this low velocity anomaly may reflect the upwelling asthenosphere, suggesting that the Abaga volcanic group and the South Gobi of the Mongolian Plateau were homologous in depth. Also there was a NEE-SWW low velocity anomaly in the depth range of 40–150 km in the east of Honggeertu volcano, which implied the upwelling of local mantle material formed by the lithospheric delamination in Songliao basin.
Exploration and identification of anoikis-related genes in polycythemia vera
Authors: Aini Wufuer , Xie Limin , Hu Wanyu , Tang Yuan , Peng Hongling , Zhang Guangsen , Deng Tuo 
Published: February 2023

Background: Polycythemia Vera (PV) is a type of typical Myeloproliferative Neoplasms (MPNs) characterized with excessive erythropoiesis and thrombosis. Anoikis is a special programmed cell death mode induced by the adhesion disorder between cells and extracellular matrix (ECM) or adjacent cells facilitating cancer metastasis. However, few studies have focused on the role of anoikis in PV, especially on the development of PV.Methods: The microarray and RNA-seq results were screened from the Gene Expression Omnibus (GEO) database and the anoikis-related genes (ARGs) were downloaded from Genecards. The functional enrichment analysis of intersecting differentially expressed genes (DEGs) and protein-protein interaction (PPI) network analysis were performed to discover hub genes. The hub genes expression was tested in the training (GSE136335) and validation cohort (GSE145802), and RT-qPCR was performed to verify the gene expression in PV mice.Results: In the training GSE136335, a total of 1,195 DEGs was obtained from Myeloproliferative Neoplasm (MPN) patients compared with controls, among which 58 were anoikis-related DEGs. The significant enrichment of the apoptosis and cell adhesion pathways (i.e., cadherin binding) were shown in functional enrichment analysis. The PPI network was conducted to identify top five hub genes (CASP3, CYCS, HIF1A, IL1B, MCL1). The expression of CASP3 and IL1B were significantly upregulated both in validation cohort and PV mice and downregulated after treatment, suggesting that CASP3 and IL1B could be important indicators for disease surveillance.Conclusion: Our research revealed a relationship between anoikis and PV for the first time by combined analysis of gene level, protein interaction and functional enrichment, allowing novel insights into mechanisms of PV. Moreover, CASP3 and IL1B may become promising indicators of PV development and treatment.