bluuebunny/crossref_metadata_2025_split huggingface dataset:
hyOPTGB: An Efficient OPTUNA Hyperparameter Optimization Framework for Hepatitis C Virus (HCV) Disease Prediction in Egypt
Authors: Elshewey Ahmed M. 
Published: April 2023

Abstract
The paper focuses on Hepatitis C Virus (HCV) infection in Egypt, which has one of the highest rates of HCV in the world. The high prevalence is linked to several factors, including the use of injection drugs, poor sterilization practices in medical facilities, and low public awareness. This paper introduces a model called hyOPTGB, which employs an optimized gradient boosting (GB) classifier to predict HCV disease in Egypt. The model's accuracy is enhanced by optimizing hyperparameters with the OPTUNA framework. Min-Max normalization is used as preprocessing step for scaling the dataset values and also, using the forward selection (FS) wrapped method to identify important features in the dataset. The dataset used in the study contains 1385 instances and 29 features and is available at the UCI machine learning repository. The authors compare the performance of five machine learning models, including decision tree (DT), support vector machine (SVM), dummy classifier (DC), ridge classifier (RC), and bagging classifier (BC), with the hyOPTGB model. The system's efficacy is assessed using various metrics, including accuracy, recall, precision, and F1-score. The hyOPTGB model outperformed the other machine learning models, achieving a 95.3% accuracy rate. The authors also conducted a comparative study of the hyOPTGB model against other models proposed by different authors who used the same dataset.
Graviton test field in sandwich wave background
Authors: Tang Ziqian 
Published: April 2023

Abstract
The scattering of test fields by sandwich waves has been studied extensively. It has been found that the energy of the scattered waves is amplified for a variety of test fields. In this paper, Scattering of gravitons by sandwich waves are calculated by solving gravitational perturbations in the sandwich wave background. Dependence of their energy amplification with respect to the sandwich wave parameters and the incident wave parameters are examined . The results show that in some cases, the energy of the outgoing graviton wave is amplified as well.
Intersections of binary quadratic forms in smooth numbers
Authors: Wang Nanxiang , Dai Haobo 
Published: April 2023

Abstract
The number of solutions to $a^{2}+b^{2}=c^{2}+d^{2}\le x$ in integers is a well-known result, while if one restricts all the variables to primes Erd\H{o}s[4] showed that only the diagonal solutions, namely, the ones with $\{a,\,b\}=\{c,\,d\}$ contribute to the main term, hence there is a paucity of the off-diagonal solutions. A natural number $n$ is $y$-smooth if the greatest prime factor of $n$ does not exceed $y$. In this paper, we restrict some of the variables to the smooth number.
MicroRNA-29 regulates tumor progression and survival through miR-29a-SIRT1-Wnt/β-catenin pathway in hepatocellular carcinoma
Authors: Qian Liqiang , Zhang Yanjun , Wang Gang , Li Bin , Zhou Hemei , Qiu Jie , Lei Qin 
Published: April 2023

Abstract
Sirtuin 1 (SIRT1) participates in the initiation and evolution of hepatocellular carcinoma (HCC). However, the specific mechanism of SIRT1 in HCC remains unsolved. The mRNA expression of miR-29a in HCC were identified by qRT-PCR. miR-29a mimic and inhibitor were employed. The alteration of biological behavior was evaluated by CCK8, clone formation, Transwell and wound-healing assay. SIRT1 was verified to be a target gene which directly regulated by miR-29a. Luciferase reporter assay and co-IP were employed to evaluate the direct binding of miR-29a and SIRT1. Animal model was used to evaluate its function on tumor growth and metastasis in vivo. The relationship between miR-29a/SIRT1 and prognosis of HCC patients was analyzed. SIRT1 overexpression accompanied by low expression of miR-29a were detected in HCC which was negatively correlated, and associated with overall survival, vascular invasion and TNM stage. Up-regulation of miR-29a suppressed cell growth and motility. Deprivation of miR-29a expression led to opposite effect. The direct binding of miR-29a to SIRT1 was confirmed by luciferase reporter assay and co-IP. miR-29a repressed SIRT1, DKK2 and β-catenin, but their expression was obviously elevated by miR-29a inhibitor. Animal model suggested miR-29a reduce SIRT1 which activated Wnt/β-catenin pathway to promote HCC growth and metastasis. Low expression of miR-29a and high expression of SIRT1 predicted shorter survival time in HCC patients. miR-29a had the function of tumor suppressor which directly inhibited oncogenic SIRT1. The loss of miR-29a led to up-regulation of SIRT1, aggravate malignant transformation and poor prognosis of HCC.
Surveillance of the Field-Incurred Pesticide Residues in Kinnow Mandarin and Evaluation of Acute, Chronic and Cumulative Exposure Risks to the Consumers
Authors: BIBI AASMA 
Published: April 2023

Abstract
Citrus fruits may serve as potential dietary exposure pathways to toxic levels of pesticides, with which they are treated. For possible protection of the consumers, pesticide residues in citrus fruits need strict and regular monitoring. This study aimed at investigating the pesticide residues status of the raw/fresh citrus fruits i.e. Kinnow Mandarin, along with evaluating exposure risks from the detected pesticides through Kinnow Mandarin consumption. Overall, 22.5% of the samples were non-complaint to the CAC-MRLs (Codex Alimentarius Commission’s established maximum residue limits) and 77.5% were exceeding the MRLs set by EU (European Union). Bifenthrin, with highest detection rate (53%), is a registered pyrethroid acaricide/insecticide for use on citrus fruits and is among the potential endocrine disrupting substances. The estimated acute/short-term (%aRfD) and chronic/long-term (%ADI) exposure values were in the range of 0.12–29.12% and 0.001–1.186%, respectively, not exceeding the hazard limit of 100% in any case. The cumulative toxicity evaluation performed for the detected neurotoxic pesticides belonging to pyrethroid, organophosphate and neonicotinoid group, indicated low potential long-term health risks from citrus fruits consumption. The results of the health risks’ estimations denote citrus fruits consumption a safer option for its consumers.
Momentary Self-esteem as a Process Underlying the Association Between Childhood Trauma and Psychosis: Experience Sampling Study
Authors: Daemen Maud , van Amelsvoort Therese ,   GROUP investigators, Reininghaus Ulrich 
Published: April 2023

Background
Exposure to childhood trauma is associated with an increased risk of developing and maintaining psychotic symptoms later in life. Self-esteem might be an important psychological process underlying the association between childhood trauma and psychosis, but there is only limited evidence to support this claim, especially in daily life.

Objective
In this study, we aimed to investigate whether exposure to childhood trauma (physical, emotional, and sexual abuse and physical and emotional neglect) moderates the cross-sectional and temporal associations between self-esteem and psychotic experiences in patients with psychotic disorders, their first-degree relatives, and controls.

Methods
We assessed momentary self-esteem and psychotic experiences in daily life using the experience sampling method in 139 patients with psychotic disorders, 118 first-degree relatives of patients with psychotic disorders, and 111 controls. Childhood trauma was measured using the Childhood Trauma Questionnaire. We fitted linear mixed models and added two-way and three-way interaction terms to test the hypotheses.

Results
The association between momentary self-esteem and psychotic experiences in daily life was modified by prior exposure to high versus low levels of several types of childhood trauma, that is, physical (χ22=24.9, family-wise error-corrected P<.001) and sexual abuse (χ22=15.9, P<.001) and physical neglect (χ22=116.7, P<.001). Specifically, momentary self-esteem was associated with more intense psychotic experiences in patients exposed to high versus low levels of physical neglect, in relatives exposed to high versus low levels of physical abuse, and in relatives and controls exposed to high versus low levels of sexual abuse. When investigating temporal order, the results showed no evidence that childhood trauma modified the temporal associations between self-esteem at tn-1 and psychotic experiences at tn or those between psychotic experiences at tn-1 and self-esteem at tn.

Conclusions
The association between self-esteem and psychotic experiences in daily life was found to be stronger in those exposed to high versus low levels of several types of childhood trauma (ie, physical abuse, sexual abuse, and physical neglect).
Platform-Based Patient-Clinician Digital Health Interventions for Care Transitions: Protocol for a Scoping Review
Authors: Backman Chantal , Papp Steve , Harley Anne , Tonjock Kolle Aurelie , Visintini Sarah , Shah Soha , Berdusco Randa , Poitras Stéphane , Beaulé Paul E , French-Merkley Veronique 
Published: April 2023

Background
With the increased adoption of technology, the use of digital health interventions in health care settings has increased. Patient-clinician digital health interventions have the potential to improve patient care, especially during important transitions between hospital and home. Digital health interventions can provide support to patients during these transitions, thereby leading to better patient outcomes.

Objective
This scoping review aims to explore the available literature, specifically (1) to examine the impact of platform-based digital health interventions focused on care transitions on patient outcomes, and (2) to identify the barriers to and enablers for the uptake and implementation of these digital health interventions.

Methods
This protocol was developed based on Arksey and O’Malley’s, Levac and colleagues’, and JBI scoping review methodologies, and it has been reported according to the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses Statement for the Scoping Reviews) format. The search strategies were developed for 4 databases: MEDLINE, CINAHL, EMBASE, and the Cochrane Central Register of Controlled Trials by using key words such as “hospital to home transition” and “platform-based digital health.” Studies involving patients 16 years or older that used a platform-based digital health intervention during their hospital to home transition will be included in this review. Two reviewers will independently screen articles for eligibility by using a 2-stage process (ie, title and abstract screening and full-text screening). We expect to refine the eligibility criteria during the title and abstract screening process as we anticipate retrieving a significant number of articles. In addition, we will also perform a targeted search of the grey literature, as well as data extraction. Data analysis will consist of a narrative and descriptive synthesis.

Results
The review is expected to identify research gaps that will inform the development of future patient-clinician digital health interventions. We have identified a total of 8333 articles. Screening began in September 2022, and data extraction is expected to commence in February 2023 and end by April 2023. Data analyses and final results will be submitted to a peer-reviewed journal in August 2023.

Conclusions
We expect to find a wide variety of postcare interventions, some gaps in the quality of research evidence, as well as a lack of detailed information on digital health interventions.

International Registered Report Identifier (IRRID)
PRR1-10.2196/42056
STRATEGI PENGEMBANGAN USAHA INDUSTRI HANDYCRAFT PADACENDERAMATA ROTAN DI KELURAHAN TONDO KECAMATAN MANTIKULORE KOTA PALU
Authors: Saputri Riski Oktavia , Muis Abdul , Sulmi Sulmi 
Published: April 2023

Indonesia merupakan penghasil rotan terbesar didunia, hampir 85% pasokan rotan dunia berasal dari Indonesia. Rotan dapat dimanfaatkan sebagai bahan baku pabrik, industri atau Home Industry, misalnya untuk pembuatan kerajinan perabot rumah tangga dan lain-lain. Tujuan penelitian yaitu menentukan strategi pengembangan usaha industri Handycraft cenderamta rotan Kelurahan Tondo Kecamatan Mantikulore Kota Palu. Penelitian ini dilaksanakan di industri
Handycraft cenderamata rotan di Kelurahan Tondo Kecamatan Mantikulore Kota Palu pada bulan Oktober sampai Desember 2021. Metode penelitian yang digunakan dalam penelitian ini adalah menggunakan analisis SWOT dengan mengidentifikasi faktor internal (Strenght dan Weakness) dan faktor eksternal (Opportunities dan Threats). Penentuan sampel ditentukan secara sengaja (purposive), jumlah sampel sebanyak 5 orang terdiri dari pemilik usaha Handycraft
cenderamata, karyawan, konsumen dan pesaing. Berdasarkan hasil analisis data yaitu diketahui pada analisis SWOT didapatkan total skor IFAS sebesar 1,80 dan total skor EFAS sebesar 2,73 hal ini menunjukkan bahwa industri Handycraft cenderama rotan berada padaposisi sumbu kekuatan (Strenght) dan peluang (Opportunities) yakni kuadran 1 artinya industri Handycraft cenderamata rotan disarankan untuk melakukan strategi progresif yaitu memanfaatkan kekuatan (Strenght) internal untuk mendapatkan keuntungan dan peluang (Opportunities) eksternal untuk mencapai pertumbuhan bisnis yang meningkat.
Plasma Insulin Concentration in Newborns and Children and Age at Menarche
Authors: Wang Guoying , Radovick Sally , Buckley Jessie P. , Hauser Russ , Williams Paige L. , Hong Xiumei , Pearson Colleen , Adams William G. , Wang Xiaobin 
Published: April 2023

OBJECTIVE
To investigate the association of plasma insulin levels and their trajectories from birth to childhood with the timing of menarche.

RESEARCH DESIGN AND METHODS
This prospective study included 458 girls recruited at birth between 1998 and 2011 and followed prospectively at the Boston Medical Center. Plasma nonfasting insulin concentrations were measured at two time points: at birth (cord blood) and in childhood (age 0.5–5 years). Age at menarche was obtained from a pubertal developmental questionnaire or abstracted from electronic medical records.

RESULTS
Three hundred six (67%) of the girls had reached menarche. The median (range) age at menarche was 12.4 (9–15) years. Elevated plasma insulin concentrations at birth (n = 391) and in childhood (n = 335) were each associated with an earlier mean age at menarche: approximately 2 months earlier per doubling of insulin concentration (mean shift, −1.95 months, 95% CI, −0.33 to −3.53, and −2.07 months, 95% CI, −0.48 to −3.65, respectively). Girls with overweight or obesity in addition to elevated insulin attained menarche about 11–17 months earlier, on average, than those with normal weight and low insulin. Considering longitudinal trajectories (n = 268), having high insulin levels both at birth and in childhood was associated with a roughly 6 months earlier mean age at menarche (mean shift, −6.25 months, 95% CI, −0.38 to −11.88), compared with having consistently low insulin levels at both time points.

CONCLUSIONS
Our data showed that elevated insulin concentrations in early life, especially in conjunction with overweight or obesity, contribute to the earlier onset of menarche, suggesting the need for early screening and intervention.
Antibacterial Activity of Rosemary Oil Against Propionibacterium acnes and The Formulation into Nanoemulsion System
Authors: Priani Sani Ega , F. Nurasyfa Rizza , Eka Darma G.C. , Fitraningsih Sri P. , Syafnir Livia , Prayitno Robby 
Published: April 2023

Acne is an inflammatory condition of the pilosebaceous unit that can occur due to infection ofPropionibacterium acnes. Rosemary essential oil contains various active compounds that haveantibacterial activity. Nanoemulsions have been developed as a delivery system to the pilosebaceousunit. This study aimed to determine the antibacterial activity of rosemary oil against P. acnes anddevelop it into a nanoemulsion system. The antibacterial activity was conducted by the agar diffusionmethod. Rosemary oil contains 1,8-cineole as the main active compound and has antibacterial activityagainst P. acnes with an inhibitory zone of 11.315±0.069 mm at a concentration of 4%. Rosemaryoil was successfully developed into a nanoemulsion system using Tween 80 as a surfactant and acombination of ethanol and PEG 400 as a co-surfactant. The rosemary nanoemulsion has a clearphysical appearance with an average globule size of 33.50±0.01 nm and a PDI value of 0.45±0.03. Thepreparation has good physical stability based on centrifugation, heating cooling, and freeze-thaw tests.The study shows that rosemary oil has antibacterial activity against P. acnes and has been successfullydeveloped into nanoemulsion preparations with good characteristics and physical stability. Keywords: Acne vulgaris, Nanoemulsion, Propionibacterium acnes, Rosemary oil.
Brand Personality as a Determinant of Consumer Loyalty of Mobile Phones and Cars in the Republic of Serbia
Authors: Stanković Jelena , Đukić Suzana 
Published: April 2023

Abstract
Brands that have highly loyal consumers are in the function of the identity and image of their personality. The primary drivers of loyalty to such brands are the intangible characteristics of brands that have a certain symbolic meaning for consumers. In that sense, brands are in the function of articulating consumers as personalities and achieving an appropriate image. To achieve this, brands are often considered individuals who, like consumers who buy them regularly, have similar characteristics. If the characteristics of brands and the characteristics of consumers are more harmonized, consumers will be more loyal. Starting from the above, the aim of the author is to investigate the influence of brand personality dimensions on consumer loyalty to two groups of products: mobile phones and cars. The research was conducted on the territory of the Republic of Serbia. The results of the research are essential for brand management because they represent guidelines for undertaking certain activities in building brands with a leading position in the market.
Reaksi Usaha Mikro Merespon Insentif Pajak dalam Investasi dan Inovasi
Authors: Kristiana Deranika Ratna , Kristianti Ika Puspita 
Published: April 2023

The purpose of this study is to identify micro-entrepreneurs who take advantage of tax incentives and MSME actors who invest in loan instruments to increase their business capital or innovate products to attract public attention for the continuity of their business. This research uses explanatory method; the testing hypothesis is formulated using descriptive qualitative data by distributing online questionnaires to micro-entrepreneurs. The total data taken was 84 respondents. The results of the study show that the reaction of micro-entrepreneurs to government policies in the final PPh has no impact on the product innovation of micro-entrepreneurs and investment in loan instruments for micro-entrepreneurs has an impact on product innovation of MSME actors. The final PPh DTP policy has implications for the reaction of micro-entrepreneurs in addressing this policy. Fiscal policy needs to be disseminated to the public, especially micro businesses. Exploration of the concept of fiscal policy refers to the latest regulations governing the DTP final PPh policy.
Keywords: Fiscal Policy; Tax Incentives; Responds Of Small Enterprises; Loan Instrument Investment; Product Innovation
MENINGKATKAN KETERBUKAAN SISWA MELALUI KONSELING INDIVIDU PERILAKU AITENDING (PTBK DI KELAS IX G SEMESTER GENAP SMP NEGERI 1 DARMARAJA TAHUN PELAJARAN 2021/2022)
Authors: Idaningsih Elis 
Published: April 2023

Bimbingan dan Konseling di sekolah bertujuan untuk membantu siswa untuk mengenal pribadinya, mengenal lingkungannya dan merencanakan masa depannya. Siswa dibimbing dan diarahkan untuk menjalani tugas perkembangan yang harus dilaluinya namun dalam kenyataannya seringkati siswa menemukan berbagai hambatan dan kesulitan. Oleh sebab itu dilakukan kegiatan penelitian ini dengan tujuan untuk membantu siswa dalam mengatasi permasalahannya sehingga siswa lebih percaya diri, lebih kompeten, lebih objektif dan bersikap positif melalui layanan konseling individu perilaku attending. Penelitian ini merupaka Penelitian Tindakan Kelas yang dilakukan dalam 2 siklus. Instrumen yang digunakan adalah lembar observasi dan panduan wawancara. Hasil penelitian menunjukkan bahwa tingkat keberhasilan konseli pada siklus 1 diperoleh hasil 59,29% (predikat Kurang) dan pada akhir pelaksanaan (siklus 2) didapat hasil 71,43% (predikat Baik). Artinya hasil tersebut menunjukkan adanya peningkatan perubahan perilaku konseli dalam upaya meningkatkan keterbukaan dirinya melalui konseling individu perilaku attending.
Spontaneous subdural hematoma concomitant with subarachnoid hemorrhage and intracerebral hemorrhage due to ruptured brain arteriovenous malformation treated with curative embolization
Authors: Soedjono Harris Kristanto , Sani Achmad Firdaus , Ekowahono Joseph , Kurniawan Dedy 
Published: April 2023

Introduction:
An arteriovenous malformation (AVM) consists of a tangled cluster of dilated blood vessels forming anomalous communication between arterial and venous systems without capillary bridging. The most likely manifestations of a ruptured AVM are intracerebral hemorrhage (ICH), subarachnoid hemorrhage (SAH), or intraventricular hemorrhage (IVH). Subdural hematoma (SDH) is exceptional in cases of ruptured brain arteriovenous malformation (BAVM).

Case Report:
A 30-year-old female was referred to the Emergency Room with a major complaint of sudden thunderclap headache 1 day before admission. The patient also complained of double vision and left ptosis that lasted for 1 day. There was no other complaint or history of hypertension, diabetes, or trauma. Non-contrast head computed tomography (CT) showed ICH-SAH-SDH on the left side of the brain which was not typical of a hypertensive pattern. The secondary ICH has a score of 6, indicating that 100% of the bleeding might be caused by underlying vascular malformation. Furthermore, cerebral angiography showed cortical plexiform BAVM on the left occipital lobe, and the patient underwent curative embolization.

Discussion:
Spontaneous SDH is very rare, and there are some hypotheses about the reasons for its occurrence. First, brain movement stretches the arachnoid layer that adheres to the AVM, resulting in direct bleeding into subdural space. Second, high-flow pia-arachnoid ruptured blood might extravasate into subdural space. Finally, the ruptured cortical artery that connects the cortex and dura layer (bridging artery) might also cause SDH. Some scoring systems are useful in BAVM, and this study selected endovascular embolization for the patient.

Conclusion:
Brain AVM rupture usually causes ICH, SAH, or IVH. Clinicians must be more aware of spontaneous SDH because it might be caused by a vascular malformation, although it is rare.