bluuebunny/crossref_metadata_2025_split huggingface dataset:
Olanzapine-induced mania
Authors: Reeves Roy R. , McBride William A. , Brannon Guy E. 
Published: April 2023

Abstract
Olanzapine is a relatively new antipsychotic agent which appears to be effective in the treatment of both the positive and negative symptoms of schizophrenia. Reported here is the case of a patient who developed symptoms of mania secondary to treatment with olanzapine. Physicians prescribing olanzapine should be aware of this potential complication.
Fortuitous diagnosis of iliac osteomyelitis: Septic arthritis of the hip in the neonate
Authors: Duffy Thomas N. , Kruse Richard W. , Massood Stephen M. , Wong Jason 
Published: April 2023

Abstract
The neonate is unable to relate specific complaints of pain and may not exhibit the usual signs of illness or infection. Septic arthritis of the hip is a surgical emergency in the neonate, and it should be considered in any irritable or ill child who has a high index of suspicion. Prompt diagnosis and immediate treatment are necessary. Nearly all babies undergo routine examination of the hip for dysplasia. It is recognized that limitation of abduction of the hip in the neonate may not represent developmental dysplasia of the hip but may represent other etiologies, such as fracture, infection, congenital anomaly, or tumor. The following case report illustrates the importance of careful clinical evaluation of an apparent asymptomatic neonate.
Thyroid hypokalemic periodic paralysis
Authors: Eugene Nida Maurice , Kanj Hassan 
Published: April 2023

Abstract
An unusual presentation of thyrotoxicosis resulting in hypokalemic periodic paralysis is reported here. The patients with this disorder have very low serum potassium levels during the active phase of the disease. Very often, several months pass before the diagnosis is made. Once recognized and the thyrotoxicosis is treated, the patient does well.
A clinician's guide to a woman's heart
Authors: Spratt Kelly Anne 
Published: April 2023

Abstract
Contrary to the perception of most women that breast cancer is the leading cause of death in women, it is heart disease and stroke that claim the most lives of women older than 35 years in the United States. The prevalence of cardiovascular disease is likely to increase as more women—notably the “baby boomers”— enter the menopausal period, a time of increased cardiac vulnerability. Primary care physicians should be on the forefront in taking an inventory of risk factors in their female patients and in educating them about the reality of heart disease in their gender and about the risk factors that these patients can modify to decrease their risk. To aid in their efforts, this article provides an overview of those risk factors that are modifiable, such as weight reduction, exercise, and smoking cessation. It also offers an evaluation of the benefit and nonbenefit of vitamin and herbal supplements in reduction of cardiac events.
Inverse design in quantum nanophotonics: combining local-density-of-states and deep learning
Authors: Liu Guang-Xin , Liu Jing-Feng , Zhou Wen-Jie , Li Ling-Yan , You Chun-Lian , Qiu Cheng-Wei , Wu Lin 
Published: April 2023

Abstract
Recent advances in inverse-design approaches for discovering optical structures based on desired functional characteristics have reshaped the landscape of nanophotonic structures, where most studies have focused on how light interacts with nanophotonic structures only. When quantum emitters (QEs), such as atoms, molecules, and quantum dots, are introduced to couple to the nanophotonic structures, the light–matter interactions become much more complicated, forming a rapidly developing field – quantum nanophotonics. Typical quantum functional characteristics depend on the intrinsic properties of the QE and its electromagnetic environment created by the nanophotonic structures, commonly represented by a scalar quantity, local-density-of-states (LDOS). In this work, we introduce a generalized inverse-design framework in quantum nanophotonics by taking LDOS as the bridge to connect the nanophotonic structures and the quantum functional characteristics. We take a simple system consisting of QEs sitting on a single multilayer shell–metal–nanoparticle (SMNP) as an example, apply fully-connected neural networks to model the LDOS of SMNP, inversely design and optimize the geometry of the SMNP based on LDOS, and realize desirable quantum characteristics in two quantum nanophotonic problems: spontaneous emission and entanglement. Our work introduces deep learning to the quantum optics domain for advancing quantum device designs; and provides a new platform for practicing deep learning to design nanophotonic structures for complex problems without a direct link between structures and functional characteristics.
Cilia and electroosmosis induced double diffusive transport of hybrid nanofluids through microchannel and entropy analysis
Authors: Munawar Sufian , Saleem Najma , Tripathi Dharmendra 
Published: April 2023

Abstract
A mathematical model is presented to analyze the double diffusive transport of hybrid nanofluids in microchannel. The hybrid nanofluids flow is driven by the cilia beating and electroosmosis in the presence of radiation effects and activation energy. Cu–CuO/blood hybrid nanofluids are considered for this analysis. Phase difference in the beatings of mimetic cilia arrays emerge symmetry breaking pump walls to control the fluid stream. Analytical solutions for the governing equations are derived under the assumptions of Debye–Hückel linearization, lubrication, and Rosseland approximation. Dimensional analysis has also been considered for applying the suitable approximations. Entropy analysis is also performed to examine the heat transfer irreversibility and Bejan number. Moreover, trapping phenomena are discussed based on the contour plots of the stream function. From the results, it is noted that an escalation in fluid velocity occurs with the rise in slippage effects near the wall surface. Entropy inside the pump can be eased with the provision of activation energy input or by the consideration of the radiated fluid in the presence of electroosmosis. The results of the present study can be applicable to develop the emerging thermofluidic systems which can further be utilized for the heat and mass transfer at micro level.
Evaluation of the properties and applications of FRP bars and anchors: A review
Authors: Ren Yuhang , Wang Hongguang , Guan Zhongzhi , Yang Kainan 
Published: April 2023

Abstract
The performance deterioration of steel anchors caused by steel corrosion is becoming more serious in slope anchorage applications. Therefore, the fiber reinforced plastic (FRP) composites have become a substitute material for traditional anchorage structures due to their advantages of low price, lightweight, high strength, and corrosion resistance. Numerous studies have proven that FRP anchors have better anchoring capacity than traditional steel anchors in practical engineering and are not as susceptible to environmental influences. This review mainly introduced the mechanical properties of FRP, focuses on the current research progress and innovation of FRP anchor in anchorage engineering, then provides a basis for the design of FRP anchor. In this study, the failure characteristics and problem of insufficient bonding strength of the first interface of FRP anchor anchoring slope were discussed, and the improvement was introduced. It will be conducive to the extension and application of FRP composites as structural materials in civil engineering. A detailed introduction is also given to biomaterials, which are mainly derived from nature and which will not only reduce waste disposal problems and environmental pollution but will also replace conventional applications. Finally, there will be an important reference and value for the development of green and sustainable engineering structures.
Associations between serum clusterin levels and non-alcoholic fatty liver disease
Authors: Wang Yansu , Shen Yun , Hu Tingting , Wang Yufei , Ma Xiaojing , Yu Haoyong , Bao Yuqian 
Published: April 2023

Objective
Clusterin is closely correlated with insulin resistance and its associated comorbidities. This study aimed to investigate the correlation between serum clusterin levels and non-alcoholic fatty liver disease (NAFLD) and further explore the mediating role of insulin resistance in this relationship.

Methods
This study enrolled 195 inpatients (41 males and 154 females) aged 18–61 years. Twenty-four patients were followed up for 12 months after bariatric surgery. Serum clusterin levels were measured using a sandwich enzyme-linked immunosorbent assay. Fatty liver disease was diagnosed on the basis of liver ultrasonography. The fatty liver index (FLI) was calculated to quantify the degree of hepatic steatosis. The mediating role of homeostasis model assessment-insulin resistance (HOMA-IR) was assessed using mediation analysis.

Results
Participants with NAFLD had significantly higher serum clusterin levels than those without NAFLD (444.61 (325.76–611.52) mg/L vs 294.10 (255.20–373.55) mg/L, P < 0.01). With increasing tertiles of serum clusterin levels, the prevalence of NAFLD displayed an upward trend (P < 0.01). Multivariate linear regression analysis showed that serum clusterin levels were a positive determinant of FLI (standardized β = 0.271, P < 0.001) after adjusting for multiple metabolic risk factors. Serum clusterin levels significantly decreased after bariatric surgery (298.77 (262.56–358.10) mg/L vs 520.55 (354.94–750.21) mg/L, P < 0.01). In the mediation analysis, HOMA-IR played a mediating role in the correlation between serum clusterin levels and FLI; the estimated percentage of the total effect was 17.3%.

Conclusion
Serum clusterin levels were associated with NAFLD. In addition, insulin resistance partially mediated the relationship between serum clusterin levels and FLI.
Live birth using autologous sperm cryopreserved for 26 years
Authors: Sleiman Sue , Bacha Feyrous , Handelsman David J 
Published: April 2023

Summary
We report the successful delivery of a healthy baby after intracytoplasmic sperm injection (ICSI) with frozen-thawed autologous sperm, cryostored for 26 years, the longest successful autologous sperm cryostorage reported. Sperm was cryostored for a 15-year-old boy at the time of his cancer diagnosis. Semen samples were frozen with cryoprotectant, using a graduated vapour-phase nitrogen protocol. Straws were stored in a large vapour-phase nitrogen tank until transfer for use. The couple underwent a single ICSI–in vitro fertilisation procedure using the frozen-thawed sperm with a transfer of five fertilised embryos, resulting in the live birth of a healthy baby boy. This reinforces the importance of offering sperm cryopreservation to men who have not completed their family prior to gonadotoxic treatment for cancer or other diseases. As practical, low-cost fertility insurance, it should be offered to any young man who can collect semen and it provides essentially unlimited duration of fertility preservation.

Learning points

Gonadotoxic chemo or radiotherapy treatment for cancer or other diseases usually causes temporary or permanent male infertility.

Sperm cryostorage serves as a practical, low-cost insurance to facilitate future paternity.

All men who have not completed their families and are scheduled for gonadotoxic treatments should be offered sperm cryostorage.

There is no lower age limit for young men who can collect semen.

Sperm cryostorage offers essentially indefinite duration for the preservation of male fertility.
Association of Lower Urinary Tract Symptoms and Benign Prostatic Enlargement in Patients with Hypertension
Authors: Stefanus Dicky , Siregar Safendra 
Published: April 2023

Development of hyperplastic nodules in the transition zone of the prostate is the characteristic of Benign prostatic enlargement (BPE). Men with hypertension have a high risk of severe lower urinary tract syndrome (LUTS). This restrospective cohort analytic study investigated the association between LUTS and BPE in hypertension patients. Subjects were BPE patients with primary hypertension who visited the urology clinic of Dr. Hasan Sadikin General Hospital Bandung that were sampled consecutively from 2017 to 2020. Three hundred and twenty-four patients from the urology department participated in the study. These patients were categorized into mild LUTS (IPSS 1-7) (n=37, 11.4%), moderate LUTS (IPSS 8-19) (n=169, 52.2%), and severe LUTS (IPSS 20-35) (n=118, 36.4%). A positive correlation (r = 0.761, p = 0.000) and weak positive correlation (r = 0.152, p = 0.006) were found between systolic blood pressure and prostate volume and between LUTS and systolic blood pressure, respectively. In addition, there was also a weak positive correlation between diastolic blood pressure and prostate volume (r = 0.065, p = 0.245) and LUTS (r = 0.015, p = 0.784). Thus, there is an association between hypertension and prostate enlargement and the severity of lower urinary tract symptoms
Modellbasierte PLT-Sicherheitsfunktionen datenbasiert überwachen
Authors: Langlitz Philipp , Lenhart Felix , Roser Martin 
Published: April 2023

In komplexen und modellbasierten PLT-Sicherheitsfunktionen werden unsicherheitsbehaftete Prozessmesswerte zur Berechnung von nicht direkt beobachtbaren Abschaltwerten verwendet, was bei Nutzung der sicherheitstechnischen Messgenauigkeitsangaben der Hersteller und üblichen Fehlerfortpflanzungsmethoden zu hohen Sicherheitsabschlägen führt. Dieser Beitrag skizziert einen Ansatz zur datenbasierten Überwachung und Anomalieerkennung für reproduzierbare, chemische Batchprozesse. was die Nutzung von geringeren Sicherheitsabschlägen auf Basis der Messwiederholbarkeit rechtfertigen, und sich somit äußerst positiv auf die Betreibbarkeit von komplexen und modellbasierten PLT-Sicherheitsfunktionen auswirken würde. Das Potenzial dieses Verfahrens zur Erhöhung des Diagnosegrads und Erkennung unbekannter Anomalien im Produktionsprozess wird anhand von historischen Prozessdaten aufgezeigt und diskutiert.
Software in Cyberphysischen Produktionssystemen
Authors: Feichtinger Kevin , Meixner Kristof , Rinker Felix , Koren István , Eichelberger Holger , Heinemann Tonja , Holtmann Jörg , Konersmann Marco , Michael Judith , Neumann Eva-Maria , Pfeiffer Jérôme , Rabiser Rick , Riebisch Matthias , Schmid Klaus 
Published: April 2023

Um den effektiven und effizienten Betrieb von Cyberphysischen Produktionssystemen (CPPSen) sicherzustellen, spielt Software eine zunehmend wichtige Rolle. Die enormen Fortschritte bei Softwareentwicklungsmethoden, welche in den letzten Jahren erzielt wurden, scheinen jedoch die aktuellen Herausforderungen der Industrie nicht zu erfüllen, weil diese die Industrie nicht oder nur langsam erreichen. In diesem Beitrag werden die Herausforderungen für die Softwareentwicklung in CPPSen aus Sicht von neun Industrievertretern aus acht europäischen Unternehmen unterschiedlicher Größe diskutiert. Um den digitalen Transformationsprozess für eine zukunftsfähige Produktion zu begleiten, wurden aus den beschriebenen Herausforderungen Perspektiven für die Forschung erarbeitet. Die Umsetzung dieser Ziele ist vor dem Hintergrund von ökonomischen, sozialen und Nachhaltigkeitsanforderungen notwendig.
Features of the Foveal Avascular Zone in Children with Active Retinopathy of Prematurity According to Optical Coherence Tomography in Angio Mode
Authors: Trifanenkova I. G. , Tereshchenko A. V. , Erokhina E. V. 
Published: April 2023

The purpose — to study the features of the foveal avascular zone (FAZ) in children with active retinopathy of prematurity according to the data of optical coherence tomography in angio-mode.Patients and methods. OCT-A was performed on 37 premature infants (37 eyes) with active ROP: at stages 1–2 — in 14 eyes (8 — with a favorable current type, 6 — with an unfavorable current), at stage 3 — in 16 eyes (6 — with a favorable type, 10 — with unfavorable), with aggressive posterior ROP — in 7 eyes (4 — at the stage of early clinical manifestations, 3 — at the stage of manifestation). Patients with stages 1 and 2 of active ROP were combined into one group due to similar findings. The control was the data of OCT-A performed on 10 premature infants without signs of ROP.Results. At 1–2 stages with a favorable type in children with a somatic state of moderate severity in the FAZ area, statistically significant differences in comparison with the control parameters were not determined. In children with a severe condition, FAZ was significantly expanded, which was accompanied by a significant decrease in the density of capillaries in the fovea. With an unfavorable type, a significant decrease in the size of the FAZ was noted, as well as a slight decrease in the density of the capillaries of the superficial plexus in the fovea. At stage 3 with a favorable type, an expansion of the FAZ, a decrease in the density of capillaries in the fovea in the superficial and deep plexus were recorded, and the values of the density of capillaries in the parafovea were slightly increased. At 3 stages with an unfavorable course in children born at a gestational age of 29–32 weeks, the FAZ was expanded. In children born at a gestational age of 25–28 weeks, a significant decrease in the size of the FAZ was recorded in comparison with children with a long gestation period, as well as those with a favorable course of stage 3. At the stage of early clinical manifestations of the posterior aggressive ROP, the FAZ was absent; vessels grew into it, which formed shunts and zones of intraretinal neovascularization in the form of “tangles”. At the stage of manifestation of the posterior aggressive ROP, a gross violation of the architectonics of the microvasculature was determined. As at the stage of early clinical manifestations, FAZ was absent; shunt vessels grew into it.Conclusion. The OCT method in angio-mode has showed high information content in studying the features of the foveal avascular zone in children with various forms, stages and types of active ROP. The characteristics of FAZ with an unfavorable type of the disease are of the greatest value for clinical practice. Their identification at the early stages of the pathological process will make it possible to timely determine the correct tactics and carry out the necessary treatment.
Psychological Domain of Elderly Patients with Diabetic Retinopathy
Authors: Fabikantov O. L. , Lev I. V. , Agarkov N. M. , Nikolashin S. I. , Titov A. A. 
Published: April 2023

The continuing increase in the prevalence of diabetic retinopathy among various segments of the population and, especially in older age, combined with a change in the psychological state of such patients. However, the study of the holistic psychological (cognitivedepressive) domain in elderly patients with various stages of diabetic retinopathy, comparable in cardiovascular pathology, which is an independent risk factor for both diabetic retinopathy and cognitive impairment, depression not carried out.Purpose: to assess the psychological domain in patients 60–74 years old suffering from diabetic retinopathy standardized for concomitant cardiovascular pathology. In the Tambov branch of the Tambov branch of S.N. Fedorov NMRC “MNTK “Eye Microsurgery” in 2019–2020, cognitive impairment and depression were studied in 68 patients with non-proliferative, 62 patients with preproliferative and 70 elderly patients with proliferative stage on the Mini-Mental-State-Examination and Center for Epidemiologic Studies — Depression scale, respectively. The diagnosis of diabetic retinopathy established based on the results of a comprehensive ophthalmological examination. The control consisted of 59 patients with the absence of diabetic retinopathy. Patients with non-proliferative stage had mild (21.5 ± 0.3 points), and with preproliferative (17.9 ± 0.4 points) and proliferative stage (16.2 ± 0.3 points) moderate cognitive impairment. The association of cognitive impairment found with preproliferative and proliferative diabetic retinopathy. The level of depression in the non–proliferative stage was 22.4 ± 0.4 points, in the preproliferative stage — 24.8 ± 0.3 points and in the proliferative stage — 26.9 ± 0.5 points versus 19.2 ± 0.3 points in the control with a significant difference in all cases. The values of the relative risk of diabetic retinopathy stages were 1,337, 2,408 and 2,796, respectively. The revealed deterioration of the cognitive-depressive domain in elderly patients with diabetic retinopathy is important for improving compliance, the effectiveness of treatment of diabetic retinopathy and the psychological continuum.
Surgical Rehabilitation of a Posttraumatic Iris Cyst, Cataract and Astigmatism Patient
Authors: Onishchenko A. L. , Potehin V. K. , Vershinina N. A. 
Published: April 2023

Injuries cause serious disturbance of the form and function of the organ of vision due to the damage and accompanying or remote complications and therefore have a high proportion to the structure of low vision, blindness and disability. One of the complications of penetrating wounds of the eye is iris cysts. Iris cyst can increase and cause pupillary block, secondary glaucoma, uveitis, corneal dystrophy, and therefore it requires surgical intervention. The goal of surgical treatment of an iris cyst is to ensure complete removal of the cyst.Objective: to estimate the clinical and functional results of treatment in a posttraumatic iris cyst, posterior subcapsular cataract and myopic astigmatism patient.Patient and methods. Patient B., 49 years old with posttraumatic retention iris cyst, posterior subcapsular cataract, compound myopic high astigmatism was examined. To determine the tactics of surgical treatment of the patient, a complex of General ophthalmology was performed (visometry, IOP measurement, autorefractometry, biomicroscopy, ophthalmoscopy), as well as special (B-scanning, optical coherence tomography of the retina) research methods. The follow-up period was 1 year.Results and discussion. To improve visual functions and prevent the development of secondary glaucoma, the patient was offered surgery — excision of the iris cyst and cataract phacoemulsification with toric intraocular lens. Simultaneous carrying out of two stages of the operation reduced the risks of postoperative complications and shorten the rehabilitation period.Conclusion. Positive optical and therapeutic effects were achieved as a result of the surgical treatment 44 years after an open eye injury: the eye is calm, the iris cyst is not detected, visual acuity has increased. The postoperative period showed the saving the stable and high visual and functional result with no recurrence of the iris cyst.