bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relationship between Gait Parameter and Spinal Sagittal profiles in Asymptomatic subjects
Authors: Wilartratsami Sirichai ,   Lopburi Nathasiri1, Vanadurongwan Bavornrat , Santipas Borriwat , Suvithayasiri Siravich , Luksanapruksa Panya 
Published: January 2023

Abstract

Background: To study the gait parameters in asymptomatic volunteers and investigate the correlation between the gait and several radiographic sagittal profiles.
Methods: Asymptomatic volunteers (20-50 years of age) were included and allocated into three subgroups depending on pelvic incidence (low, normal, and high). Standing whole spine radiographs and gait analysis data were obtained. The Pearson Coefficient Correlation was used to determine the relationship between the gait and radiographic profiles.
Results: A total of 55 volunteers (28 male and 27 females) were included. The mean age was 27.35±6.37 years old. The average sacral slope (SS), pelvic tilt (PT), pelvic incidence (PI), and PI-LL mismatch (PI-LL) were 37.78±6.59, 14.51±9.19 degrees, and 52.29±10.87 degrees and -0.36±11.41, respectively. The mean velocity and stride of all the volunteers were 119.00±30.12 cm/s and 130.25±7.72 cm, correspondingly. The correlation between each of the radiographical and gait parameters was low (ranging from -0.24 to 0.26).
Conclusion: Gait parameters were not differenced significantly between each of the PI subgroups in asymptomatic volunteers. Spinal sagittal parameters also showed a low correlation with gait parameters.
Full C-band wavelength-tunable, 250 MHz repetition rate mode-locked polarization maintaining fiber laser
Authors: Jang Yoon-Soo , Park Jungjae , Jin Jonghan 
Published: January 2023

Abstract
We demonstrate a full C-band wavelength-tunable mode-locked fiber laser with a repetition rate of 250 MHz, representing the highest repetition rate for C-band tunable mode-locked lasers thus far to the best of our knowledge. The polarization-maintaining fiber-based Fabry-Perot cavity enables a fundamental repetition rate of 250 MHz with a semiconductor saturable absorber mirror as a mode-locker. We observed a stable and single soliton mode-locking state with wide tunability of the center wavelength from 1505 nm to 1561 nm by adjusting the incident angle of a bandpass filter inside the cavity. The full C-band covered wavelength-tunable high repetition rate mode-locked laser is expected to be a compelling source for many frequency-comb-based applications, including high-precision optical metrology, broadband absorption spectroscopy, and broadband optical frequency synthesizers.
GPR116 receptor regulates the antitumor function of NK cells via HIF1α/NF-κB signaling pathway as a potential immune checkpoint
Authors: Guo Dandan , Jin Chenxu , Gao Yaoxin , Lin Haizhen , Zhang Li , Zhou Ying , Yao Jie , Duan Yixin , Ren Yaojun , Hui Xinhui , Ge Yujia , Yang Renzheng , Jiang Wenzheng 
Published: January 2023

Abstract
Background
NK cell is one of innate immune cells and can protect the body from cancer-initiating cells. It has been reported that GPR116 receptor is involved in inflammation and tumors. However, the effect of GPR116 receptor on the NK cells remains largely unclear.
Results
We discovered that GPR116−/− mice could efficiently eliminate pancreatic cancer through enhancing the proportion and function of NK cells in tumor. Moreover, the expression of GPR116 receptor was decreased upon the activation of the NK cells. Besides, GPR116−/− NK cells showed higher cytotoxicity and antitumor activity in vitro and in vivo by producing more GzmB and IFNγ than wild-type (WT) NK cells. Mechanistically, GPR116 receptor regulated the function of NK cells via HIF1α/NK-κB signaling pathway. Furthermore, downregulation of GPR116 receptor promoted the antitumor activity of NKG2D-CAR-NK92 cells against pancreatic cancer both in vitro and in vivo.
Conclusions
Our data indicated that GPR116 receptor had a negatively effect on NK cells function and downregulation of GPR116 receptor in NKG2D-CAR-NK92 cells could enhance the antitumor activity, which provides a new idea to enhance the antitumor efficiency of CAR NK cell therapy.
Ionospheric disturbances over South America related to Tonga Volcanic Eruption
Authors: Takahashi Hisao , Figueiredo C. A. O. B. , Barros D. , Wrasse C. M. , Giongo G. A. , Honda R. H. , Vital L. F. R. , Resende L. C. A. , Nyassor P. K. , Ayorinde T. T. , Carmo C. S. , Padua M. B. , Otsuka Y. 
Published: January 2023

Abstract
On January 15, 2022, we observed various unusual atmospheric wave events over South America: Atmospheric pressure waves (Lamb mode) around 12:30 to 17:30 UT, tsunamis along the Chilean coast at around 17:00 to 19:00 UT, and ionospheric disturbances between 11:30 and 20:00 UT. We understand that these events were generated by the Tonga volcanic eruption that occurred at (20.55°S, 175.39°W) in South Pacific Ocean at 04:15 UT. Several traveling ionospheric disturbances (TIDs), the horizontal wavelengths of 330 to 1174 km and the phase speed of 275 to 544 m/s were observed before and after the Lamb wave passed over the continent and the arrival of the tsunami on the Chile coast. The observed TID characteristics suggest us that these waves might be generated above the mesosphere far from the observation site. This is the first time to report the signature of ionospheric disturbances over the South American continent generated by the huge volcanic eruption.
Transcriptome profiling of a synergistic volumetric muscle loss repair strategy
Authors: Roberts Kevin , Kim John Taehwan , Huynh Tai , Schluns Jacob , Dunlap Grady , Hestekin Jamie , Wolchok Jeffrey C 
Published: January 2023

Abstract
Volumetric muscle loss overwhelms skeletal muscle’s ordinarily capable regenerative machinery, resulting in severe functional deficits that have defied clinical repair strategies. In this manuscript we pair the early in vivo functional response induced by differing volumetric muscle loss tissue engineering repair strategies that are broadly representative of those explored by the field (scaffold alone, cells alone, or scaffold + cells) to the transcriptomic response induced by each intervention. We demonstrate that an implant strategy comprising allogeneic decellularized skeletal muscle scaffolds seeded with autologous minced muscle cellular paste (scaffold + cells) mediates a pattern of increased expression for several genes known to play roles in axon guidance and peripheral neuroregeneration, as well as several other key genes related to inflammation, phagocytosis, and extracellular matrix regulation. The upregulation of several key genes in the presence of both implant components suggests a unique synergy between scaffolding and cells in the early period following intervention that is not seen when either scaffolds or cells are used in isolation; a finding that invites further exploration of the interactions that could have a positive impact on the treatment of volumetric muscle loss.
Subtle phenotypic effects of mosaic trisomy X in monozygotic twins with Prader-Willi syndrome: case report and review of literature
Authors: Huang Xinjiang , Yin Xi , Zhang Manping , Cai Yanna , Li Xiuzhen , Zhang Wen , Zeng Chunhua , Liu Li , Mao Xiaojian 
Published: January 2023

Abstract
Background

We described the first monozygotic twins with 46, XX/47, XXX mosaicism and Prader-Willi syndrome, who were manifested with typical Prader-Willi syndrome (PWS) symptoms and slight trisomy X characteristics. Trisomy X symptoms can differentiate greatly, ranging from no significant manifest to special appearance, whereas 46, XX/47, XXX mosaicism may be rather inapparent.

Case presentation

The twin girls (B1 and B2) were born with weak cry, axial hypotonia, sucking difficulties and PWS facial appearance. They were also manifested with clinodactyly, inappropriate low birth weight, epicanthal folds and congenital heart disease, too atypical to be likely caused by PWS alone and indicating an associated problem. The diagnosis of 46, XX/47, XXX mosaicism and Prader-Willi syndrome was established based on clinical suspicion and molecular analysis. Therapy were conducted, followed by 4 years’ follow-up.

Conclusions

This report illustrates the first monozygotic twins with 46, XX/47, XXX mosaicism and Prader-Willi syndrome. Subtle phenotypic effects of mosaic trisomy X in monozygotic twins with Prader-Willi syndrome may be significance in prognosis and genetic counseling.
Factors associated with plasmid antibiotic resistance gene carriage revealed using large-scale multivariable analysis
Authors: Orlek Alex , Anjum Muna , Mather Alison , Stoesser Nicole , Walker Sarah 
Published: January 2023

Abstract
Plasmids are one of the main vectors of bacterial antibiotic resistance, but understanding of risk factors associated with plasmid antibiotic resistance gene (ARG) carriage is limited. We curated > 14000 publicly available plasmid genomes and associated metadata. Duplicate and replicate plasmids were excluded; where possible, sample metadata was validated externally (BacDive database). Using Logistic Generalised Additive Models (GAMs) we assessed the influence of biotic/abiotic factors (e.g. plasmid genetic factors, isolation source, collection date) on ARG carriage, modelled as a binary outcome. Separate GAMs were built for 10 major ARG types. Multivariable analysis indicated that plasmid ARG carriage patterns across time (collection years), isolation sources (human/livestock) and host bacterial taxa were consistent with antibiotic selection pressure as a driver of plasmid-mediated antibiotic resistance. Only 0.42% livestock plasmids carried carbapenem resistance (compared with 12% human plasmids); conversely, tetracycline resistance was enriched in livestock vs human plasmids (adjusted odds-ratio [OR] = 2.65, 95% confidence interval [CI] 1.89–3.72), reflecting known prescribing practices. More recently acquired ARG types (e.g. colistin and carbapenem) showed increases in plasmid carriage during the date range analysed (1994–2019), potentially reflecting recent onset of selection pressure; they also co-occurred less commonly with ARGs of other types, and virulence genes. Carbapenem resistance was more likely to reside on conjugative vs non-mobilisable plasmids (adjusted OR = 3.59 95%CI 2.80–4.61), and on plasmids with a higher density of insertion sequences. Overall, this suggests that following acquisition, plasmid ARGs tend to accumulate under antibiotic selection pressure and co-associate with other adaptive genes (other ARG types, virulence genes), potentially re-enforcing plasmid ARG carriage through co-selection.
Involvement of Siglec-15 in regulating RAP1/RAC signaling in cytoskeletal remodeling in osteoclasts mediated by macrophage colony-stimulating factor
Authors: Takahata Masahiko , Kobayashi Hideyuki , Ota Masahiro , Hasegawa Tomoka , Terkawi Mohamad Alaa , Yamamoto Tomomaya , Shimizu Tomohiro , Sato Dai , Fujita Ryo , Amizuka Norio , Iwasaki Norimasa 
Published: January 2023

Abstract

DNAX-associated protein 12 kDa size (DAP12) is a dominant immunoreceptor tyrosine-based activation motif (ITAM)-signaling adaptor that activates costimulatory signals essential for osteoclastogenesis. Although several DAP12-associated receptors (DARs) have been identified in osteoclasts, including triggering receptor expressed on myeloid cells 2 (TREM-2), C-type lectin member 5A (CLEC5A), and sialic acid-binding Ig-like lectin (Siglec)-15, their precise role in the development of osteoclasts and bone remodeling remain poorly understood. In this study, mice deficient in Trem-2, Clec5a, Siglec-15 were generated. In addition, mice double deficient in these DAR genes and FcεRI gamma chain (FcR)γ, an alternative ITAM adaptor to DAP12, were generated. Bone mass analysis was conducted on all mice. Notably, Siglec-15 deficient mice and Siglec-15/FcRγ double deficient mice exhibited mild and severe osteopetrosis respectively. In contrast, other DAR deficient mice showed normal bone phenotype. Likewise, osteoclasts from Siglec-15 deficient mice failed to form an actin ring, suggesting that Siglec-15 promotes bone resorption principally by modulating the cytoskeletal organization of osteoclasts. Our results further demonstrated that Siglec-15 may be involved in macrophage colony-stimulating factor (M-CSF) signaling; therefore, mediating cytoskeletal organization of osteoclasts via promoting activation of the Ras-associated protein-1 (RAP1)/Ras-related C3 botulinum toxin substrate 1 (RAC1) pathway, which is an essential component of the canonical osteoclast cytoskeletal organization complex. Furthermore, biochemical analysis revealed that Sigelc-15 activates M-CSF-induced Rac1 pathway through formation of a complex with p130CAS and CrkII, leading to cytoskeletal remodeling of osteoclasts. Our data provide genetic and biochemical evidence that Siglec-15 facilitates M-CSF-induced cytoskeletal remodeling of the osteoclasts.
Quality of Life in the Digital Age: Young Adult Hematopoietic Stem Cell Transplantation Patients and Healthcare Providers' Views of Telehealth
Authors: Sauls Rachel , Crowder Sylvia , James Christy , Khimani Farhad , Stern Marilyn 
Published: January 2023

Abstract
Purpose: The COVID-19 pandemic shifted the healthcare field from in-person clinic visits to virtual-based telehealth appointments. This study explores young adult (YA) hematopoietic stem cell transplantation (HSCT) patient and physician communication preferences and quality of life (QOL) implications for telehealth.
Methods: One researcher conducted semi-structured interviews with n=10 YA HSCT patients and n=10 healthcare providers (HPs). HPs included physicians (n=5) and APP (nurse practitioners and physician assistants) (n=5). Interviews lasted approximately 10-15 minutes, were held over Zoom®, and were audio recorded. Interviews were professionally transcribed verbatim, and two independent researchers conducted a thematic analysis using Dedoose®.
Results: Common themes that emerged included: 1) convenience; 2) improved communication; 3) technology issues; and 4) quality of life. Most patients (n=7; 70%) preferred in-person visits over telehealth, stating they chose the "social connection" and "engagement" associated with in-person visits. However, 50% of patients (n=5) referred hybrid appointments for check-in or follow-up visits. 80% of physicians (n=4) preferred telehealth visits stating it was "convenient," "timesaving," and improved "compliance." In contrast, all APP staff (n=5; 100%) preferred in-person visits, stating in-person improved "relationships" with patients and was more "convenient" than setting up their electronic devices for a telehealth visit.
Conclusion: Providers differed in their preferences, with APP personnel preferring in-person visits compared to telehealth and HSCT physicians preferring telehealth or hybrid appointments. YA HSCT patients preferred in-person or hybrid clinic visits for non-necessary appointments.
Social Determinants of Health, Religiosity and Tobacco Use in Sub-saharan Africa: Evidence From the Global Adult Tobacco Survey in Seven Countries.
Authors: Ogbodo Stephen Chukwuma , Onyekwum Chinyere Abigail 
Published: January 2023

AbstractBackground Tobacco use is projected to increase in sub-Saharan Africa (SSA) over the next century, and delineating the patterns of inequality in tobacco use will facilitate its control within this region. Methods Using nationally representative data from Global Adult Tobacco Surveys (GATS) conducted in seven SSA countries (2012–2018), this study explores the association between the social determinants of health and tobacco use among SSA adults. The surveys provided information on 47,246 adults aged 15 years or older in Cameroon, Ethiopia, Kenya, Nigeria, Senegal, Tanzania, and Uganda. Current tobacco use prevalence was estimated in each country overall and across socioeconomic and demographic factors (sex, age, residence, education, wealth, religion, marital status, and tobacco health knowledge). Multiple logistic regression analysis was used to assess the association of these determinants with current tobacco use in each country and for the combined dataset. The pooled data analysis was further stratified by tobacco product category and sex. Results We found significant homogenous associations between the social determinants and tobacco use across all countries. For the pooled data, smoking was independently associated with male sex, rural residence, greater age, lower education and health knowledge, and irreligiousness. For smokeless tobacco (SLT) use, the trends were similar and stronger for all determinants except sex. Among women only, the odds of smoking and SLT use respectively increased and decreased with greater wealth. Conclusions Tobacco use is significantly associated with socioeconomic deprivation in SSA (stronger for SLT use than for smoking). These findings highlight opportunities for targeted interventions within SSA.
Robust Sequential Stopping Games
Authors: Igietsemhe Israel , Lee Chi-Guhn 
Published: January 2023

Abstract
We study the robust equilibrium for sequential stopping games to give the conditions under which the game’s values exist. Three scenarios of the game are analyzed. G1 is the game where only the maximizing player optimizes in a worst-case scenario and G2 is the game where only the minimizing player optimizes in a worst-case scenario.We show that under the conditions of integrability and time consistency, the game value exists for robust zero-sum two-person sequential stopping games (G1, G2) when the payoff process is an ambiguous adapted process under multiple probability measures. We also establish the relationship between G1 and G2.
MSC Classification: 62L15 , 91A15
PNF technique combined with extracorporeal shock wave in the treatment of hemiplegia caused by upper cervical perimedullary arteriovenous fistula embolization:clinical experience and review of literature
Authors: Lin Shaoping , Lee Yining , Yu Jin , Wang Shixiong 
Published: January 2023

Abstract
Purpose-Research of rehabilitation for postoperative dysfunction of Spinal dural arteriovenous fistula, especially perimedullary arteriovenous fistula, are still rare. This literature is a young patient with hemiplegia after embolization regained limb motor function by using extracorporeal shock wave to reduce muscle tension and PNF technique to enhance muscle strength and strengthen neural control.
Methods-A 3-year and 11 months old girl fell down while riding a scooter and accidentally detected cervical spinal canal vascular malformation by brain MRI. The final diagnosis was perimedullary arteriovenous fistula with subarachnoid hemorrhage, C3-4 level. Total cerebrovascular angiography + spinal angiography + aortic arch angiography +C3-4 level perimedullary arteriovenous fistula interventional embolization was completed. The muscle strength of the right limb decreased after surgery, and the muscle strength of the right limb improved after dilation, vasodilation, and hormone shock therapy. At our initial assessment, we found that the patient could not lift the upper limb to hold a cup and could not stand. After 2 weeks of PNF technique combined with extracorporeal shock wave therapy, Manual Muscle Testing was used to evaluate the progress of muscle strength, modified Ashworh scale was used to evaluate muscle tension, and Barthel index was used to evaluate the dependence degree of daily life. The Time Up and Go Test and the Gaitwatch 3D Gait Analysis and Evaluation System are used to evaluate gait.
Results-After 2 weeks of treatment, her motor function has been greatly recovered, she can lift the upper limbs, and walk independently. the score of the modified Ashworth scale(MAS) on Triceps Surae decreased from 2/5 to 1/5. Barthel index increased from 25/100 to 85/100. Deltoid strength increased from 1/5 to 3/5, Triceps strength increased from 1/5 to 4/5, Iliopsoas strength increased from 2/5 to 3/5, Quadriceps strength increased from 2/5 to 4/5, and tibialis anterior strength increased from 0/5 to 2/5. In gait, the hip joint and pelvis have almost the same movement trajectory as the left side in the stance phase and swing phase, but the ankle joint still has foot drop at the beginning and end of gait.
Conclusions-PNF technique combined with extracorporeal shock wave could effectively improve the muscle tone, muscle strength, and gait of hemiplegia patients after upper cervical perimedullary arteriovenous fistula embolization.
This literature reports a very rare case of hemiplegia after upper cervical perimedullary arteriovenous fistula embolization, which was able to walk independently after 2 weeks of rehabilitation.
Nance-Horan Syndrome: Characterization of dental, clinical and molecular features in three new families
Authors: Guven Yeliz , Saracoglu Hilal Piril , Aksakal Sermin Dicle , Kalaycı Tugba , Altunoglu Umut , Uyguner Zehra Oya , Eraslan Serpil , Borklu Esra , Kayserili Hülya 
Published: January 2023

Abstract
Background: Nance–Horan syndrome (NHS; MIM 302350) is an extremely rare X-linked dominant disease characterized by ocular and dental anomalies, intellectual disability, and facial dysmorphic features.
Case presentation: We report on five affected males and two symptomatic females from three unrelated NHS families. The clinical diagnosis in patient 1 (P1) was confirmed by targeted Sanger sequencing. Patient 2 (P2), boy aged 6 months, was evaluated due to preliminary diagnosis of syndromic microphthalmia and 300KSNP-array was performed. In family 3 (F3), two maternal half-brothers (P3 and P4) and their maternal uncle (P5), X-linked inheritance was sought for and Duo-WES was planned. P1 showing bilateral cataracts, iris heterochromia, microcornea, mild intellectual disability, and dental findings including Hutchinson incisors, supernumerary teeth, bud-shaped molars carried a novel pathogenic variant, c. 2416C>T; p.(Gln806*). P2 presenting with global developmental delay, microphthalmia, cataracts, and ventricular septal defect revealed a novel deletion encompassing 22 genes including the NHS gene. His lower incisors were in screwdriver shaped. P3, P4 and P5 had history of congenital cataracts and mild-moderate intellectual deficiency. Additionally, P3 displayed autistic and psychobehavioral features. Half-brothers had bud-shaped molars. P4 also presented with notched incisors, bud-shaped permanent molars, and supernumerary molars. Duo-WES analysis on half-brothers showed a hemizygous novel deletion, c.1867delC; p.(Gln623ArgfsTer26).
Conclusions: Our findings not only broaden the spectrum of genetic etiopathogenesis associated with NHS but also highlight the importance of dental professionals to be made aware of the features. Dental professional could be the first specialist involved in the diagnosis of NHS since dental findings are highly distinctive for this syndrome.
Urban-rural inequalities and spatial arrangement of informed choice of FP in Ethiopia: further analysis of 2016 Ethiopian demographic health survey
Authors: Tareke Abiyu Abadi , Takele Bayley Adane , Ahmed Mohammedjud Hassen , Tegegne Masresha Derese , Eshetu Habitu Birhan 
Published: January 2023

Abstract
Background
Ethiopia has showed satisfactory progress in the improvement of maternal and child health in the last two decades. Adoption of family planning through informed choice is among the main strategy to achieve favorable maternal and child health. But this favorable progress might have masked the substantial urban-rural inequalities in informed choice of family planning.
Objective
To identify the contributing factors for the observed urban-rural inequalities and to determine spatial arrangement of informed choice of family planning in Ethiopia.
Methods
The study utilized information from 3,511 (weighted) currently contraceptive user women (rural-2685 and urban-826) from the most recent release cross-sectional data of Ethiopian demographic health survey. Spatial and Descriptive, bivariable, and multivariable logit-based decomposition analysis techniques were used.
Results
the spatial configuration of not informed choice was clustered. The primary cluster (LLR = 34.8, p-value < 0.001) was southern portion of Amhara region that covers east & west Gojjam, south Gondar and south Wollo administrative zones. The