bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analyzing the Influencing Factors on Quality of Life of Older People with Swallowing Dysfunction in Nursing Homes in China
Authors: Li Qianru , Li Laiyou , Sun Ning , Wang Hongyin , Fan Chaoyan , Chen Shuangqin , Li Hongyu , Yang Shuang 
Published: April 2023

Abstract
Background To investigate the prevalence of dysphagia among the older adult population in nursing homes and unravel the relevant factors that precipitate quality of life of the older adults with swallowing dysfunction in nursing homes༎Methods Based on 102 individuals aged 50 years or older, with dysphagia, and who were admitted in community nursing home, we examined the demographic characteristic, the nutritional indices and the possible quality of life related variables through a cross-sectional study.Results The reliability and validity of the C-DHI scale were proven high. The incidence of swallowing disorder risk in the older adult population of care institutions is 90.2%, and the incidence of nutrition risk and malnutrition is 67.64%. The general linear regression results show that the standard regression coefficient of FOIS is -2.75, P = 0.007. The standard regression coefficient of nutritional methods is -3.84, P = 0.000, and the difference was statistically significant, indicating that the C-DHI scale was negatively correlated with FOIS and nutrition methods.Conclusions Swallowing disorders are also identified as a major problem amongst the older adult population in nursing homes, as there is a high prevalence of dysphagia among this population group. There are many factors related to the quality of life. The swallowing mechanism changes significantly as people age, even in the absence of chronic diseases. More attention to controllable influencing factors would improve the quality of life of older adults with swallowing dysfunction.
Effect of Fetal-type Posterior cerebral artery on cerebral infarction and collateral circulation
Authors: Bai Fan , Hou Bei , Liu Hui , Lei Zhu , Guo Shanshan , Yang Chao , Liu Minghao , Dong Suhe , Huang Aihua , Wang Jianan 
Published: April 2023

Abstract
We studied 57 patients with cerebral infarction and Fetal-type Posterior cerebral artery (FTP)\, confirmed by MRA and CTA. 26 cases (45.61%) of Complete Fetal-type Posterior cerebral artery (cFTP), 21 cases (36.84%) of Partial Fetal-type Posterior cerebral artery (pFTP), 10 cases (17.54%) of unilateral cFTP.When the ipsilateral internal carotid artery occlusion of cFTP occurs, the bidirectional collateral circulation from the posterior circulation to the posterior communication artery to the anterior circulation cannot be established to compensate, simultaneous infarction of the ipsilateral anterior and posterior circulation can be caused. In the presence of pFTP, since the diameter of P1 was less than that of the posterior communicating artery (PcoA), the collateral circulation of posterior circulation - posterior cerebral artery - middle cerebral artery pia meningeal anastomosis could not be established, anterior circulation infarction was caused by ipsilateral internal carotid artery occlusion. In the presence of bilateral cFTP, the anterior circulation-posterior communication artery-basilar artery could not be established to compensate for the collateral circulation of other branches except bilateral posterior cerebral artery, resulting in bilateral cerebellar and brainstem infarction. FTP changes the cerebral artery circulation and collateral circulation pathways in the normal state.
Risk perception and public pandemic fatigue: the role of perceived stress and preventive coping
Authors: Wang Bin , Zhong Xiao , Fu Haojie , Zhang Haobo , Hu Ruilin , Chen Changxia 
Published: April 2023

Abstract
This study explores the current status of pandemic fatigue, predictors, and their mechanisms of action based on a stress-response framework and a parallel model of future-oriented response. Study 1 investigated 8426 adult residents' understanding of and willingness to cooperate with the pandemic prevention and control policies, and found that public understanding of and willingness to cooperate with prevention policies were significantly lower in 2022 than in both 2020 and 2021. Study 2 surveyed 1635 residents on their motivation to prevent and control the pandemic. The results found that risk perception negatively predicted motivation to prevent and control the pandemic; perceived stress and preventive coping significantly mediated the relationship between risk perception and motivation to prevent and control the pandemic; but perceived stress and proactive coping did not significantly mediate the relationship between risk perception and motivation to prevent and control the pandemic. This revealed an increase in public fatigue in the third year of the pandemic. Pandemic fatigue can be predicted by pandemic risk perception, but the direct pathway of action is not significant and requires the mediation of perceived stress and preventive coping.
LGALS2 and EGR1: markers of endometriosis for predictive, preventive and personalized medicine
Authors: Jiang Hong , Sun Qinkun , Huang Zhixiong , Chen Hui , Chen Lihong , He Xinqin 
Published: April 2023

Abstract
Endometriosis (EM) is a chronic gynecological disorder that causes infertility and chronic pelvic pain. The aim of the current study was to identify markers of efferocytosis with utility for EM diagnosis.RNA sequencing profile and single-cell sequencing (scRNA-seq) data were collated from the Gene Expression Omnibus (GEO) database and 46 efferocytosis-related genes (ERGs) from Genecards. Results of single-cell, differential expression and Weighted Gene Co-expression Network Analysis (WGCNA) were combined into a Venn diagram to identify 41 intersecting genes. LGALS2, EGR1 and CLINT1 were shown to be key EM markers by least absolute shrinkage and selection operator (LASSO) and support vector machine-recursive feature elimination (SVM-RFE) algorithms. Area under the curve (AUC) values were 0.9 for LGALS2, 0.81 for EGR1 and 0.76 for CLINT1, indicating good diagnostic efficacy. Functional annotation analysis revealed the markers to be enriched in cell cycle, DNA repair, neuroactive ligand-receptor interactions, cell cycle, chromosomal segregation and other pathways. Drug-gene interaction network indicated that beta-D-glucose, pseudoephedrine and fostamatinib were potential therapeutic agents, exposing the possibility of personalized medicine for EM. RT-qPCR showed LGALS2 and EGR1 to be more highly expressed in ectopic than in eutopic endometrium. LGALS2 and EGR1 are introduced as potential novel targets for risk prediction, non-invasive diagnosis and health care personalization in EM. The potential for personalized medicine (PPPM) to treat EM patients is illuminated.
Exploring the mechanism of action of Glycyrrhiza glabraee for diabetic encephalopathy based on network pharmacology and in vitro experiments
Authors: Fu Chuanjun , Tao Jiasheng , Yang Liang , Tan Xinxin , Zeng Xueling , LI Xian hui , Li Zhongzheng 
Published: April 2023

Abstract
To investigate the mechanism of action of Glycyrrhiza glabra in the treatment of diabetic encephalopathy using network pharmacology techniques and in vitro experiments. The TCMSP database was used to obtain the relevant chemical components and action targets of licorice, and then the disease target genes related to diabetic encephalopathy were obtained by GeneCards, OMIM and PharmGkb, and the corresponding targets of drug components and disease targets were taken as intersection targets; Cytoscape software was used to construct the component-target network map; the STRING database was used to draw The core targets were screened out by network topology analysis; GO function and KEGG signaling pathway enrichment analysis were performed by R 4.0.3 software; target-pathway network map was constructed by Cytoscape software; finally, the core components and key targets were validated by molecular docking technology and in vitro experiments. The analysis yielded 125 potential active ingredients, including key compounds such as isoglycyrrhizin, glycyrrhizin and quercetin; by topological analysis, 36 core genes were obtained, including GSK3β, AKT1, FOS, PPARG and other genes, which is mainly involved in IL-17 signaling pathway, PI3K/Akt signaling pathway, insulin resistance, neurodegenerative pathway-multiple diseases and In vitro experiments showed that ILG in licorice may act on GSK3β to regulate P13K/AKT/GSK3β signaling pathway and thus treat diabetic encephalopathy. This study fully embodies the concept of holistic and systematic view of Chinese medicine in disease treatment, and provides a theoretical basis and research method for the treatment of diabetic encephalopathy.
Reciprocal regulation of forkhead box C1 and L1 cell adhesion molecule contributes to triple-negative breast cancer progression
Authors: Zhang Fan , Xu Yue , Lin Jiediao , Pan Hongchao , Cui Yukun 
Published: April 2023

Abstract
Purpose Forkhead box C1 (FOXC1) may act as a therapeutic target for triple-negative breast cancer (TNBC) but without a comprehensive understanding of its regulations, especially at the upstream. L1 cell adhesion molecule (L1CAM) is a transmembrane glycoprotein that may involve in brain metastasis. Indicated by a positive correlation between FOXC1 and L1CAM transcripts, this study aims to further examine their relation in the process of TNBC.Methods FOXC1 and L1CAM transcripts were downloaded from two public datasets, and their proteins were examined in four TNBC cell lines. FOXC1 and L1CAM were separately knocked down in BT549 cells; L1CAM was overexpressed in BT549-shFOXC1, MDA-MB-231, and HCC1937 cells. CCK-8, transwell and wound healing assays were conducted in these cells, so was immunohistochemical staining in tumors.Results L1CAM and FOXC1 transcripts were positively correlated in public datasets. BT549-shFOXC1 cells showed a decreased L1CAM expression both at the transcriptional and protein levels. Intriguingly, BT549-siL1CAM cells displayed decreased FOXC1 proteins, but exerted little effect on FOXC1 transcripts. Conversely, overexpression of L1CAM resulted in upregulation of FOXC1 protein without substantial change in FOXC1 mRNA, that consistently observed in BT549-shFOXC1, MDA-MB-231-L1CAM and HCC1937-L1CAM cells. Additionally, decreased or increased capacities of cell proliferation, migration, and invasion were seen along with down- or up-regulation of FOXC1 or L1CAM. Finally, a positive correlation between L1CAM and FOXC1 proteins was observed in human TNBC tumors.Conclusion FOXC1 and L1CAM display coregulation at the protein level but not mRNA level to positively affect cell proliferation, migration and invasion in TNBC.
The Role of Vitamin D On Interferon- Levels in Indonesian Children with Down Syndrome And Its Contributing Factors: A Cross-sectional Study
Authors: Hisbiyah Yuni , Endaryanto Anang , Setyoboedi Bagus , Rochmah Nur , Faizi Muhammad , Maharani Asri 
Published: April 2023

Abstract
Background Vitamin D (VD) plays a role in reducing the risk of diseases related to the immune system, including autoimmune diseases, by inhibiting proinflammatory cytokines such as IFN-γ. Children with Down syndrome (DS) are known to have interferonopathy due to trisomy 21 and have lower VD levels. This study aimed to evaluate the VD profile in Indonesian children with DS and its correlation with IFN-γ.Methods This study was conducted from March 2020 to June 2021 at Dr. Soetomo General Hospital, Surabaya. Data on sociodemographic status, milk, fish, and meat consumption, and sun exposure were obtained using a self-report questionnaire. VD and IFN-γ levels were measured using an ELISA kit. The chi-square test, t-test, Mann–Whitney test, and linear and logistic regression analysis were performed, with a significance threshold of p < 0.05.Results Of the 122 participants, 80 children had DS and 42 did not. The median VD levels in the DS and non-DS groups were 31.98 ng/mL and 56.19 ng/mL, respectively. The IFN-γ level was higher in the DS group, but this difference was not statistically significant (122.978 ± 123.420 vs. 100.715 ± 97.137 ng/mL, p = 0.548). Children with DS had lower daily milk consumption (300 cc/day vs. 380 cc/day; p = 0.027), sun exposure (17.5 vs. 150 hours/week; p = 0.000), and weekly meat and fish consumption (1 vs. 4 slices/week; p = 0.000). Daily milk consumption was a significant contributing factor for VD adequacy in the DS group (p = 0.000 [OR = 1.008]). VD levels had a significant role in decreasing IFN-γ levels in the DS group (p = 0.039; R2 = 5.8%).Conclusions VD levels in children with DS are lower than in children without DS. Adequate milk consumption can reduce the risk of autoimmunity through the role of VD in reducing IFN-γ levels in children with DS.
Organic cushioned material maintaining natural wood structure
Authors: Sakagami Hiroki , Tsuda Tetsuya 
Published: April 2023

Abstract
Bio-based plastic materials ecofriendly produced at low energy cost are receiving increasing attention as alternatives to traditional fossil-based plastic materials. Herein, we successfully prepared an elastic softened wood sample via a simple treatment comprising impregnation with an ionic liquid and subsequent heating. Wood appearance characteristics such as growth rings and brown color were retained throughout the treatment. The modified wood material exhibited lower compressive stress than the control specimens by approximately 5% and complete shape recovery after compression. Fourier transform infrared analysis indicated the partial removal of lignin and hemicellulose in this treatment with the ionic liquid, and the absence of morphological alterations, such as the dissolution of wood cell walls, was confirmed by a scanning electron microscopy. The elastic properties were derived from the preferential deformation of the thin cell walls in the earlywood region. Moreover, the dissolution of wood components produced slight softening without hindering shape recovery. The prepared organic material is expected to replace fossil-based plastic cushioning materials.
Exploring the Relationship between Social Isolation, Oral Health, and Cognitive Function in Elderly Residents of Guangxi: A Cross-Sectional Study
Authors: Huang Dongmei , Li Caili , Pan Qini , Zhang Guining , Pan Yanfei , Tao Pinyue , Huang Huiqiao 
Published: April 2023

Abstract
Background Social isolation is a state of active or passive detachment from society that accelerates the decline of physical and mental functions of the elderly and leads to various adverse consequences. However, the relationship between social isolation and oral health as well as cognitive function has not yet been established.Methods This was a cross-sectional survey conducted on an older population, where we collected data from 530 older adults using the General Information Questionnaire, LSNS-6, OHAT, and MoCA-B. The purpose of the survey was to investigate the current status of social isolation and its influencing factors, as well as to explore the relationship between oral health, cognitive function, and social isolation among the elderly.Results In Guangxi, the incidence of social isolation among the elderly was 10.38%, with the high risk of social isolation accounting for 53.77%. Marital status, place of residence (urban or rural), cognitive function, and oral health status were identified as factors influencing social isolation among the elderly. The study found a negative correlation between the oral health score and social isolation score (r = -0.373, P < 0.001), with unhealthy oral status showing the strongest correlation with social isolation (r = -0.448, P < 0.001). Additionally, cognitive function scores were positively correlated with social isolation scores (r = 0.377, P < 0.001), with dementia showing the strongest association with social isolation (r = 0.324, P < 0.001). Furthermore, oral health demonstrated a high screening capacity for social isolation (AUC 95% CI = 0.823 (0.757, 0.890)), with an optimal cut-off value of 9.5, sensitivity of 67.3%, specificity of 90.1%, and Yoden index of 0.574.Conclusion The social isolation status of the elderly is influenced by various factors, including marital status, residence (urban or rural), cognitive function, and oral health status. Moreover, the Oral Health Assessment Tool (OHAT) can be utilized as an effective objective tool for screening social isolation among the elderly.
Novel Antitubercular Agent-Loaded Liposomal Vesicles: Optimization, Characterization, and Cytotoxicity Studies
Authors: Obiedallah Manar M. , Mironov Maxim A. , Belyaev Danila V. , Ene Antoaneta , Vakhrusheva Diana V. , Krasnoborova Svetlana Yu. , Bershitsky Sergey Y. , Shchepkin Daniil V. , Minin Artem S. , Ishmetova Rashida I. , Ignatenko Nina K. , Tolshchina Svetlana G. , Fedorova Olga V. , Rusinov Gennady L. 
Published: April 2023

Abstract
The treatment of tuberculosis is still a challenging process due to the wide spread of pathogen strains resistant to antibacterial drugs, as well as the undesirable effects of anti-tuberculosis therapy. Hence, the development of safe and effective new anti-antitubercular agents in addition to suitable nanocarrier systems has become of utmost importance and necessity. Our research aims to develop liposomal vesicles that contain newly synthesized compounds with antimycobacterial action. The compound being studied is a derivative of imidazo-tetrazine named 3- (3,5-dimethylpyrazole-1-yl) -6-(isopropylthio) imidazo [1,2-b] [1, 2, 4, 5] tetrazine (compound 1). Several factors that affect the liposomal characteristics were studied. The maximum encapsulation efficiency was 53.62 ± 0.09. The selected liposomal formulation T8* possessed mean particle size about 205.3 ± 3.94 nm with PDI 0.282, and zeta potential was + 36.37 ± 0.49 mv. The results of the in vitro release study indicated that the solubility of compound 1 was increased by its incorporation in liposomes. The free compound and liposomal preparation showed antimycobacterial activity against M. tuberculosis H37Rv (ATCC 27294) at MIC value 0.94–1.88 µg/ml. We are predicting that the liposomes may be a good candidate for delivering of new antitubercular drugs.
Insight into the underlying molecular mechanism of dilated cardiomyopathy through integrative analysis of data mining, iTRAQ-PRM proteomics and bioinformatics
Authors: Xiong Hongli , zheng zhe , Zhao Congcong , Zhao Minzhu , Wang Qi , Zhang Peng , Li Yongguo , Zhu Ying , Zhu Shisheng , Li Jianbo 
Published: April 2023

Abstract
Dilated cardiomyopathy (DCM) is a common cardiomyopathy worldwide, which is characterized by ventricular dilatation and systolic dysfunction. DCM is one of the most common diseases contributing to sudden death and heart failure. However, our understanding of its molecular mechanisms is limited because of its etiology and underlying mechanisms. Poor access to human myocardium is a significant limitation in the study of DCM. Firstly, DCM disease target genes were downloaded from public databases, and 935 genes were identified as key target genes. Next, a total of 787 differentially expressed proteins (DEPs), including 353 up-regulated and 434 down-regulated proteins, were identified in our animal experiment. The functional annotation of these DEPs revealed complicated molecular mechanisms including oxidation-reduction process, tricarboxylic acid cycle, protein folding, and triggered a series of molecular pathways involving TCA cycle, Oxidative phosphorylation, Cardiac muscle contraction. Finally, the DEPs were analyzed for association with the target genes screened in the public dataset. The overlapping proteins were validated by parallel reaction monitoring (PRM). We obtained 154 key proteins and further determined the importance of these three pathways. Together, this study provided deep insights into the detailed molecular mechanisms of DCM and facilitated the identification of potential proteins associated with it.
Ultrasound 2d Fetal Developing Brain Image Classification and Disease Prediction
Authors: Sridha K , Gokul N , Giridharan L , Akashdeep V 
Published: April 2023

Abstract
Ultrasound imaging processing technology has been employed for more than 50 years. Although it has developed quickly, it has some advantages and particular challenges. It is crucial to establish the fetal survival rate, gestational age, and other factors early on, from the standpoint of ultrasound picture analysis. In a bid to better understand the fetus's continuing growth, fetal anatomy ultrasound image analysis techniques have recently been studied and have emerged as an essential tool for prenatal anomaly diagnosis. The moment has come to thoroughly analyse prior efforts in this area and forecast future directions. Thus, this article discusses cutting-edge methods along with fundamental concepts, theories, and advantages and disadvantages of ultrasound picture technology for the entire fetal along with different anatomies. It begins by summarizing the ongoing issues and introducing the widely used image processing techniques, such as classification, segmentation, etc. We provided the necessary data performance on table 1 that is Fig. 4.
Interaction of Bromine with Cu(100) surface: adsorption and thermodynamics stability study
Authors: Marashdeh Ali , Saraireh Sherin A. , Elrashidi Ali , Alghamdi Suzan K. , Afaneh Akef T. , Helal Wissam , Altarawneh Mohammednoor 
Published: April 2023

Abstract
Ab initio atomistic thermodynamics adapted using density functional theory and to study the effect of Bromine (Br) chemisorption on the Cu(001) surface is with coverage (0.11, 0.25, 0.5, 0.75 and 1) ML. H site with coverage of 0.25ML is the most preferred site followed by B site with the order of stability of (H > B > T). The majority of Br atoms stable at B site. Significant structural changes are observed for the first layer’s Cu atoms. For instance, for the bridge (B) site with coverage \(\ge 0.5\)ML, one of the Cu atoms moves from first to second layer, For the hollow H(0.75 and 1) ML and H(0.75 and 1) ML configurations; two Br’s layers thin film are produced on the top of the slab. The substitutional adsorption modes are stable for coverages from 0.25ML up to 2ML. Under ultrahigh-vacuum conditions, the free energies of different Br/Cu(110) structures as a function of Bromine chemical potential are calculated, these calculated energies showed that the bridge site is the most stable for coverages of 1/9ML, whereas the bridge and hollow configurations are the most stable at 1/4ML coverage. Thermodynamics insights provided herein shall be instrumental to underpin bromine interaction with Cu surfaces in applications related to environmental chemistry as in the thermal recycling of e-waste.