bluuebunny/crossref_metadata_2025_split huggingface dataset:
Systematic radiomics analysis based on multiparameter MRI to preoperatively predict the expression of Ki67 and histological grade in patients with bladder cancer
Authors: Fan Xuhui , Yu Hongwei , Ni Xie , Chen Guihua , Li Tiewen , Chen Jingwen , He Meijuan , Liu Hao , Wang Han , Yin Xiaorui 
Published: March 2023

Objectives:
Bladder cancer is among the most prevalent urothelial malignancies. Radiomics-based preoperative prediction of Ki67 and histological grade will facilitate clinical decision-making.

Methods:
This retrospective study recruited 283 bladder cancer patients between 2012 and 2021. Multiparameter MRI sequences included: T1WI, T2WI, diffusion-weighted imaging (DWI), and dynamic contrast-enhanced (DCE) imaging. The radiomics features of intratumoral and peritumoral regions were extracted simultaneously. Max-Relevance and Min-Redundancy (mRMR) and least absolute shrinkage and selection operator (LASSO) algorithms were employed to select the features. Six machine learning-based classifiers were adopted to construct the radiomics models, and the best was chosen for the model construction.

Results:
The mRMR and LASSO algorithms were more suitable for Ki67 and histological grade, respectively. Additionally, Ki67 had a higher proportion of intratumoral features, while peritumoral features accounted for a greater proportion of the histological grade. Random forests performed the best in predicting both pathological outcomes. Consequently, the multiparameter MRI (MP-MRI) models achieved area under the curve (AUC) values of 0.977 and 0.852 for Ki67 in training and test sets, respectively, and 0.972 and 0.710 for the histological grade.

Conclusion:
Radiomics holds the potential to predict multiple pathological outcomes of bladder cancer preoperatively and are expected to provide clinical decision-making guidance. Furthermore, our work inspired the process of radiomics research.

Advances in knowledge:
This study demonstrated that different feature selection techniques, segmentation regions, classifiers, and MRI sequences will affect the performance of the model. We systematically demonstrated that radiomics can predict histological grade and Ki67.
Dissolving Constraints for Riemannian Optimization
Authors: Xiao Nachuan , Liu Xin , Toh Kim-Chuan 
Published: March 2023

In this paper, we consider optimization problems over closed embedded submanifolds of [Formula: see text], which are defined by the constraints c(x) = 0. We propose a class of constraint-dissolving approaches for these Riemannian optimization problems. In these proposed approaches, solving a Riemannian optimization problem is transferred into the unconstrained minimization of a constraint-dissolving function ( CDF ). Different from existing exact penalty functions, the exact gradient and Hessian of CDF are easy to compute. We study the theoretical properties of CDF and prove that the original problem and CDF have the same first-order and second-order stationary points, local minimizers, and Łojasiewicz exponents in a neighborhood of the feasible region. Remarkably, the convergence properties of our proposed constraint-dissolving approaches can be directly inherited from the existing rich results in unconstrained optimization. Therefore, the proposed constraint-dissolving approaches build up short cuts from unconstrained optimization to Riemannian optimization. Several illustrative examples further demonstrate the potential of our proposed constraint-dissolving approaches. Funding: The research of N. Xiao and K.-C. Toh is supported by the Ministry of Education of Singapore Academic Research Fund Tier 3 [Grant MOE-2019-T3-1-010]. The research of X. Liu is supported in part by the National Natural Science Foundation of China [Grants 12125108, 11971466, 12288201, 12021001, and 11991021]; the National Key R&D Program of China [Grants 2020YFA0711900 and 2020YFA0711904]; and the Key Research Program of Frontier Sciences, Chinese Academy of Sciences [Grant ZDBS-LY-7022].
The Dual Effects of Team Contest Design on On-Demand Service Work Schedules
Authors: Dong Tingting , Sun Xiaotong , Luo Qi , Wang Jian , Yin Yafeng 
Published: March 2023

Emerging on-demand service platforms (OSPs) have recently embraced teamwork as a strategy for stimulating workers’ productivity and mediating temporal supply and demand imbalances. This research investigates the team contest scheme design problem considering work schedules. Introducing teams on OSPs creates a hierarchical single-leader multi-follower game. The leader (platform) establishes rewards and intrateam revenue-sharing rules for distributing workers’ payoffs. Each follower (team) competes with others by coordinating the schedules of its team members to maximize the total expected utility. The concurrence of interteam competition and intrateam coordination causes dual effects, which are captured by an equilibrium analysis of the followers’ game. To align the platform’s interest with workers’ heterogeneous working-time preferences, we propose a profit-maximizing contest scheme consisting of a winner’s reward and time-varying payments. A novel algorithm that combines Bayesian optimization, duality, and a penalty method solves the optimal scheme in the nonconvex equilibrium-constrained problem. Our results indicate that teamwork is a useful strategy with limitations. Under the proposed scheme, team contest always benefits workers. Intrateam coordination helps teams strategically mitigate the negative externalities caused by overcompetition among workers. For the platform, the optimal scheme can direct teams’ schedules toward more profitable market equilibria when workers have inaccurate perceptions of the market. History: This paper has been accepted for the Service Science Special Issue on Innovation in Transportation-Enabled Urban Services. Funding: This work was supported by the National Science Foundation [Grant FW-HTF-P 2222806]. Supplemental Material: The online appendices are available at https://doi.org/10.1287/serv.2023.0320 .
Measurement of resonant bend loss in anti-resonant hollow core optical fiber: erratum
Authors: Carter Richard M. , Yu Fei , Wadsworth William J. , Shephard Jonathan D. , Birks Tim A. , Knight Jonathan C. , Hand Duncan P. 
Published: March 2023

An error on the part of the authors in drafting resulted in Eq. (3) being incorrect in the published paper [Opt. Express 25, 20612 (2017)10.1364/OE.25.020612]. We present a corrected version of the equation. It should be noted that this does not affect the presented results or conclusions of the paper.
Relationship between oral health and prognosis in patients with empyema: Single center retrospective study with propensity score matching analysis
Authors: Iwata Eiji , Nishiuma Teruaki , Hori Suya , Sugiura Keiko , Taki Masato , Tokunaga Shuntaro , Kusumoto Junya , Hasegawa Takumi , Tachibana Akira , Akashi Masaya 
Published: March 2023

Background
Empyema is a life-threatening infection often caused by oral microbiota. To the best of our knowledge, no reports have investigated the association between the objective assessment of oral health and prognosis in patients with empyema.

Materials and methods
A total of 63 patients with empyema who required hospitalization at a single institution were included in this retrospective study. We compared non-survivors and survivors to assess risk factors for death at three months, including the Renal, age, pus, infection, diet (RAPID) score, and Oral Health Assessment Tool (OHAT) score. Furthermore, to minimize the background bias of the OHAT high-score and low-score groups determined based on the cut-off value, we also analyzed the association between the OHAT score and death at 3 months using the propensity score matching method.

Results
The 3-month mortality rate was 20.6% (13 patients). Multivariate analysis showed that a RAPID score ≥5 points (odds ratio (OR) 8.74) and an OHAT score ≥7 points (OR 13.91) were significantly associated with death at 3 months. In the propensity score analysis, a significant association was found between a high OHAT score (≥7 points) and death at 3 months (P = 0.019).

Conclusion
Our results indicated that oral health assessed using the OHAT score may be a potential independent prognostic factor in patients with empyema. Similar to the RAPID score, the OHAT score may become an important indicator for the treatment of empyema.
Interaction of acute heart failure and acute kidney injury on in-hospital mortality of critically ill patients with sepsis: A retrospective observational study
Authors: Hu Tianyang , Yao Wanjun , Li Yu , Liu Yanan 
Published: March 2023

Background
The present study aimed to evaluate the synergistic impact of acute heart failure (AHF) and acute kidney injury (AKI) on in-hospital mortality in critically ill patients with sepsis.

Methods
We undertook a retrospective, observational analysis using data acquired from the Medical Information Mart for Intensive Care-IV (MIMIC-IV) database and eICU Collaborative Research Database (eICU-CRD). The effects of AKI and AHF on in-hospital mortality were examined using a Cox proportional hazards model. Additive interactions were analyzed using the relative extra risk attributable to interaction.

Results
A total of 33,184 patients were eventually included, comprising 20,626 patients in the training cohort collected from the MIMIC-IV database and 12,558 patients in the validation cohort extracted from the eICU-CRD database. After multivariate Cox analysis, the independent variables for in-hospital mortality included: AHF only (HR:1.20, 95% CI:1.02–1.41, P = 0.005), AKI only (HR:2.10, 95% CI:1.91–2.31, P < 0.001), and both AHF and AKI (HR:3.80, 95%CI:13.40–4.24, P < 0.001). The relative excess risk owing to interaction was 1.49 (95% CI:1.14–1.87), the attributable percentage due to interaction was 0.39 (95%CI:0.31–0.46), and the synergy index was 2.15 (95%CI:1.75–2.63), demonstrated AHF and AKI had a strong synergic impact on in-hospital mortality. And the findings in the validation cohort indicated identical conclusions to the training cohort.

Conclusion
Our data demonstrated a synergistic relationship of AHF and AKI on in-hospital mortality in critically unwell patients with sepsis.
EFFECT NICKEL AND QUENCH-TEMPER PROCESS ON MECHANICAL AND CORROSION PROPERTIES OF ASTM A588 WAETHERING STEEL
Authors: Rohmah Miftakhur - , Ramadhan Gilang , Irawan Dedi , Utama Dedi Pria , Romijarso Toni Bambang 
Published: March 2023

The mechanical improvement and "self-protection" properties are mainly needed to develop weather-resistant steel materials. In this study, A588 steel was given thermomechanical treatment (hot-rolling) followed by a quench-tempering process. The A588 is modified by adding 1, 2, and 3 wt% nickel to the primary alloy. Steel is made using a hot rolling process at 750 ℃ for 1 hour with 70% thickness reduction. The sample is heat-treated at 850 ℃ for 1 hour and quenched in water, oil, and open air. The tempering process is conducted at 400 ℃ for 30 minutes. Metallography test is confirmed final microstructural and compared with CCT simulation result. The fast cooling (water and oil quenchant) produces tempered martensite, ferrite, and pearlite, while the air-cooled forms a ferrite-pearlite. The cooling rate significantly affects strength and hardness and the nickel addition on hardness, and both factors have no significant on ductility. The sample owns the highest tensile strength value (~1226 MPa) with 1 %Ni, and the highest ductility value (around 17.1–27.43%) is obtained by air cooling. With 3% Ni, the corrosion rate decreases to 0072 mpy with -432.5 mV for corrosion potential and 0.12µA/cm-2 for current density.
Economic effects of environmental change on the rural areas
Authors: Ferencz Árpád , Komarek Levente , Csiba Anita , Deák Zsuzsanna 
Published: March 2023

Agriculture is one of the economic sectors most directly affected by
climate change. Agriculture must adapt to changed environmental and
biological conditions in order to be effective. In extreme cases, certain
areas must be completely set aside due to soil erosion or desertification.
At the same time, agricultural activity is not only a victim of global
climate change, but also one of the causes of it. In our work, we examine
climate change in Hungary, projecting it into agriculture where extreme
weather conditions are most noticeable. As a testing area, we chose the
Hungarian Sand Dunes area because of the diversified agricultural
production here and because this part of the country is most affected by
climate change. The Homokhátság occupies a significant part of Hungary and
has always been a major agricultural production center. The homestead farms
established here define the image of the Hungarian Great Plain. Interviews
with local farmers provide an overview of the local impacts of climate
change and measures to mitigate the expected and future damages in the
farms surveyed.
In our research, we shed light on the causes, extent and
consequences of climate change, especially in the areas of agriculture. We
present climate impacts and measures to reduce them through secondary and
primary research.
Aspects regarding the role of investments and the business
environment in economic development
Authors: Sirbulescu Claudia , Pirvulescu Luminita , Iosim Iasmina , Feher Andrea , Rujescu Ciprian 
Published: March 2023

The paper presents an analysis of investments as the safest prospect
for economic growth. In Romania, investments are needed to recover the
economic gaps as compared to the European Union countries, but also to
reduce the differences between regions.
Sustainable development of the country must solve the challenges of
the transition from the industrial to the digital economy, of adapting and
confronting climate change, of demographic change, to which the corrections
of economic imbalances due to the consumption-based growth model must be
added.
Investments can be made by the business environment (large
companies, consortia, multinationals) operating in Romania. Investments can
also be made through projects that are funded from the European Union
budget.
Investment stimulates job-creating economic sectors that will
generate economic growth.
First of all, the investments must be financed by allocating funds
through domestic possibilities, to which the attraction of foreign direct
investments is added. An important role in this regard belongs to the
legislative framework, which determines the removal of barriers for
investment, but also to the attraction of Romania's economy which is
different from one economic sector to another. In the article, the authors
presented the main aspects of investments and aimed to highlight the effect
of investments on the business environment.
The genetic diversity assessment of new potato varieties of different
maturity groups by SSR markers
Authors: Prysiazhniuk Larysa , Sonets Tetiana , Shytikova Yuliia , Hryniv Svitlana 
Published: March 2023

The purpose of study was to assess the genetic diversity of potato
varieties of different maturity groups by SSR markers. Twenty-four potato
varieties of different maturity groups (very early, yearly, medium, late)
were investigated by 8 SSR markers (STM0019, STM3009, STM2005, STM2028,
STM3012, STM3023, STM5136, STM5148) for genetic diversity assessment. To
assess the genetic diversity of studied varieties, the cluster analysis was
performed and the genetic distances between varieties were determined.
As results of PCR analysis from 6 to 10 alleles were determined with
an average of 7.88 alleles. The most polymorphic marker was STM2028 with
PIC 0.89. The lowest value of PIC (0.78) was obtained for STM3012 marker.
For other studied markers values of PIC were from 0.82 to 0.88. It was
found, that the most similar varieties are varieties with genetic distance
3.74: Pravda and Riviera, Pravda and Vzirets. The most different varieties
turned out to be Vzirets and Lilly, ESMEE and Opilla varieties with genetic
distance 6.00. Thus, it was found that the major of studied varieties
formed cluster grouts according their maturity groups.
Desenvolvimento de doce da fruta da palma forrageira (Opuntia fícus- indica (L.) Mill.)) adicionado de farinha da casca do maracujá
Authors: Costa Mérida Layara Xavier , Couto Luzia Almeida , Almeida Érica Sandy Rocha de , Castro Eleidervan da Silva , Silva Silvania Lopes da , Santos Roberta Alves , Domingues Robson Queiros , Moreira Edinilda de Souza 
Published: March 2023

A palma forrageira é uma cactácea cultivada em zonas árida e semiárida para a produção de forragem para o gado nos períodos de estiagem. Os frutos produzidos são muito apreciados pela população, encontrados nas feiras e mercados na época da colheita, no entanto, o fruto da palma possui valorização e exploração ainda restrita. A elaboração de doces, em geral, é uma das formas empregadas para conservação de frutas. Com a perspectiva de realizar a exploração do fruto da palma forrageira, o presente estudo, tem como objetivo elaborar o doce da fruta da palma forrageira adicionado da farinha da casca do maracujá, e verificar quanto a viabilidade para implementação no mercado alimentício. A elaboração do doce da fruta da palma forrageira, adicionado da farinha da casca do maracujá, visa desenvolver um produto que tenha em sua composição nutrientes benéficos à saúde, contribuindo para a exploração de um fruto que possui grande potencial econômico para ser empregado no setor alimentício. Além disso, a produção desse doce contribui para redução de impactos ambientais, uma vez que atua no reaproveitamento da casca do maracujá. Para analisar o perfil geral dos consumidores, foi elaborado um formulário composto por 13 perguntas objetivas. Foram obtidos respostas de 87 entrevistados, sendo estes escolhidos de forma aleatória. Ao analisar os dados obtidos, foi possível verificar que o público em questão estava aberto a novas tendências e inovações no mercado alimentício.
Educação do Campo: Um Estudo de Caso na Escola André Fideles de Araújo situada na Zona Rural de Parnamirim-PE
Authors: Santos Ana Karolyna Silva , França Aurenia Pereira de 
Published: March 2023

As políticas públicas educacionais brasileiras voltadas para educação no campo tem apresentado grande evolução no decorrer dos últimos anos. Apesar dos avanços, a realidade das escolas campesinas ainda revelam grandes desafios, com demandas pedagógicas, logísticas e infra-estruturais, incluindo-se as condições socioeconômicas dos alunos. Dessa forma o objetivo deste trabalho consistiu-se em analisar o cenário da educação do campo por meio de um estudo realizado na Escola André Fidelis de Araújo, situada no município de Parnamirim-PE. O objetivo foi identificar as dificuldades enfrentadas por seus professores e alunos, levando-se em consideração a observância de alguns aspectos principais: o projeto político pedagógico implementado na instituição, o processo de ensino-aprendizagem, a infraestrutura do ambiente escolar, as classes multisseriadas, a formação dos docentes e as disparidades com relação às escolas urbanas. Trata-se de um estudo de caso, qualitativo de caráter descritivo exploratório. Os dados foram coletados a partir de entrevistas, com roteiro semiestruturado, aplicado a uma amostra de duas docentes da instituição. Percebeu-se uma similaridade das respostas entre as duas docentes, sobre a caracterização da escola, bem como realidade da escola do campo de maneira geral. Foi considerado pelas respondentes que, o maior desafio enfrentado pelo corpo docente na Escola do Campo André Fidelis de Araújo são as classes multisseriadas, que tornam o seu trabalho exaustivo e não efetivo quanto a prática pedagógica. Dessa forma, concluiu-se que faz-se necessário, para maior efetividade no processo ensino-aprendizagem, um currículo integrador, que leve em consideração as necessidades daqueles que vivem no campo, assim como de projetos que tornem este processo assertivo e congruente com a realidade onde é vivenciado.
Clinical assessment of SNIBE Maglumi SARS-CoV-2 antigen fully-automated chemiluminescent immunoassay
Authors: Pighi Laura , Henry Brandon M. , De Nitto Simone , Gianfilippi Gianluca , Salvagno Gian Luca , Plebani Mario , Lippi Giuseppe 
Published: March 2023

Abstract

Objectives
Given that SARS-CoV-2 antigen tests will represent a pillar for supporting or surrogating molecular testing in the endemic period, we report here the clinical performance of the new SNIBE Maglumi SARS-CoV-2 antigen fully-automated chemiluminescent immunoassay (MAG-CLIA SARS-CoV-2 Ag).

Methods
The study population consisted of 181 subjects (mean age 61 ± 21 years; 92 females) undergoing coronavirus disease 2019 (COVID-19) testing at the local diagnostic facility, from December 2022 to February 2023. Routine diagnostic practice involved the collection of a double nostril nasopharyngeal swab, analyzed in duplicate with SARS-CoV-2 antigen (MAG-CLIA SARS-CoV-2 Ag) and molecular (Altona Diagnostics RealStar SARS-CoV-2 RT-PCR Kit) tests.

Results
A significant Spearman’s correlation was found between MAG-CLIA SARS-CoV-2 Ag and mean Ct values of SARS-CoV-2 E and S genes (r=−0.95; p<0.001). In all nasopharyngeal samples, the area under the curve (AUC) of MAG-CLIA SARS-CoV-2 Ag was 0.86 (95% CI, 0.81–0.90), with 0.71 sensitivity and 1.00 specificity at 7 ng/L cut-off, increasing to 0.98 (95% CI, 0.96–1.00) AUC and 0.96 sensitivity (with 0.97 specificity) in high viral load samples. When SARS-CoV-2 N protein concentration was replaced with raw instrumental readings (i.e., relative light units [RLU]), the AUC in all samples increased to 0.94. A RLU value of 945 was associated with 88.4% accuracy, 0.85 sensitivity, 0.95 specificity, 0.77 negative predictive value (NPV) and 0.97 positive predictive value (PPV), respectively.

Conclusions
We found satisfactory analytical performance of MAG-CLIA SARS-CoV-2 Ag, which could be used as surrogate of molecular testing for identifying high viral load samples. Broadening the reportable range of values may generate even better performance.
Antidiabetic, antihyperlipidemic and protective effects of Gladiolus psittacinus on hyperglycemia-mediated oxidative stress in streptozotocin-induced diabetic rats
Authors: Karigidi Kayode Olayele , Akintimehin Emmanuel Sina , Karigidi Mojisola Esther , Adetuyi Foluso Olutope 
Published: March 2023

Abstract

Objectives

Gladiolus psittacinus (GP) is an important medicinal plant in folk medicine where its corm is used for treatment of diabetes mellitus. Despite this, there is paucity of scientific information to justify its use as antidiabetic drug. Hence, this study was designed to explore antidiabetic, antihyperlipidemic and effects of aqueous extract of Gladiolus psittacinus (AGP) on hyperglycemia-associated oxidative stress in pancreas, kidney and liver of diabetic rats.

Methods
Diabetes mellitus (DM) was induced in rats using streptozotocin 50 mg/kg (i.p.). Normal and diabetic rats were treated orally with AGP once a day for 14 days. Antidiabetic effects were evaluated on body weight, fasting blood glucose concentration (FBGC), lipid profiles and serum chemistry. Also, protective effects of AGP were also determined on markers of oxidative stress, antioxidant enzymes and histopathology of pancreas, kidney and liver of diabetic rats.

Results
Treatment with AGP emanated to significant decrease of FBGC (552.67–157.33 mg/dL), increase in body weight (100.01–133.76 g) and positive modulation of lipid parameters in diabetic rats. The alteration in the contents of markers of liver and kidney function were significantly modulated in the diabetic rats upon treatment. Also, oxidative damage and antioxidant depletions in pancreas, kidney and liver were significantly mitigated in treated diabetic rats. Structural aberrations in the histopathology slides of pancreas, kidney and liver were improved upon treatment.

Conclusions
It can be concluded that AGP could be used in the treatment of diabetes mellitus and its related ailments, thereby justifying its usage in traditional medicine.