bluuebunny/crossref_metadata_2025_split huggingface dataset:
Xanthoma of the Bone Mimicking Malignant Bone Tumor with Secondary Aneurysmal-Cystic Change: A Case Report
Authors: Yang Ming-Tao , Yeh Lee-Ren , Wan Hsi-Hao , Tsai Jen-Wei , Kao Yu-Hsi , Yeh Jih-Hsi , Li Yi-Chen 
Published: April 2023

Abstract
Background
Xanthomas are commonly found in the soft tissues of hyperlipidemic patients. Rarely, they may involve the skeletal system, with various radiographic appearances, mimicking bone malignancies.
Case presentation:
A 55-year-old woman presented with back pain and bilateral lower limb weakness for several months. After serial imaging studies, multifocal osteolytic lesions were identified in the pelvis and spine, with the largest measuring 94 mm in diameter. An abnormal lipid profile and typical cutaneous presentation aided in the final pathological diagnosis of bone xanthoma.
Conclusions
Xanthoma of the bone may be confused with aggressive bone lesions radiologically. Clinical, laboratory, and physical findings, in addition to pathological features, are required to make an accurate diagnosis.
Oral administration of wasabi extract containing 6-methylsulfinylhexyl isothiocyanate is safe and improves brain fatigue and sleep in healthy volunteers
Authors: Nakajima Ryota , Kanou Masanobu , Yamana Kei , Tokushima Masahiko , Iwama Yoshitaka 
Published: April 2023

Abstract
Background: This study aimed to conduct a preliminary evaluation of the effects of 6-methylsulfinylhexel isothiocyanate (6-MSITC) contained in wasabi rhizomes on brain fatigue and sleep and examine its safety through overdose study.
Methods: A total of 20 healthy volunteers who were experiencing daily fatigue were given wasabi extract powder containing 6-MSITC (4.8 mg/day of 6-MSITC) for 4 weeks. Then, fatigue, sleep, autonomic nerves, stress, and immunity were evaluated. In addition, overdose safety study of the extract powder (up to 16 mg/day of 6-MSITC for 4 weeks) was performed with 30 healthy volunteers in double-blind placebo-controlled method.
Results: Wasabi extract powder containing 6-MSITC did not improve fatigue after mental task, but fatigue before mental task, sleep and mood were improved significantly after 4 weeks intake. No changes were observed in the autonomic nerve function, stress, or immune markers. In the overdose safety study, no changes in the parameters or side effects were observed, and the results showed that overdosing on wasabi extract powder containing 6-MSITC was safe.
Conclusion: This study confirmed the possibility that wasabi extract powder containing 6-MSITC may improve brain fatigue and sleep. However, since the effectiveness evaluation in this study was a single-arm, open-label study and there was no placebo control group, these points must be considered when interpreting the results. Safety was confirmed in an overdose study of more than three times the amount compared to that in the efficacy evaluation study. In the future, further research should be conducted on brain fatigue and sleep with wasabi extract powder containing 6-MSITC.
Trial registration: UMIN clinical trial registration system, UMIN000049913. Registered 27 December 2022 Retrospectively registered, https://center6.umin.ac.jp/cgiopen-bin/ctr/ctr_view.cgi?recptno=R000056818
Simulation of Ch3nh3pb(I 1-x Br X ) 3 Using Copper Iodide as Efficient Htl
Authors: chaudhary srishtee , Mehra Rajesh , Raj Balwinder 
Published: April 2023

Abstract
This paper presents theoretical research work for device simulation of solar cells based on Methylammonium lead iodide CH3NH3Pb(I1 − XBrx)3 concentration, band offsets, and other characteristics that have an impact on efficiency. SCAPs software is utilized to model and simulate the proposed solar cell. The results obtained of the proposed solar cell design have high efficiency of 36.44%. Copper iodide (CuI) as the hole transport material and Tin oxide (SnO2F) as the transparent conducting oxide are implemented in design to analyze the characteristics of perovskite solar cells (PSC). The results demonstrate that the proposed design have identical concepts but enhanced outcome compared to the existing one. The quantum efficiency curve depicts that the perovskite material has good absorption across the full visible spectrum. CH3NH3Pb(I1 − XBrx)3 solar cells are emerging as an important renewable energy source for current and future context. Research is being carried for enhancement in solar cell designs.
The Experience of Patients with Hematological Malignancy in their Terminal Stage: A Phenomenological Study
Authors: Alnaeem Mohammad M. , Shehadeh Anas , Nashwan Abdulqadir J. 
Published: April 2023

Abstract

Background

Patients diagnosed with hematological malignancies and residing in low-middle-income countries undergo significant physical and psychological stressors. Despite this, only a mere 16% of them receive proper care during their terminal stages. Therefore, it is crucial to gain insight into the unique experiences of this patient population.

Aim

To gain a better understanding of the needs and lived experiences of adult patients with advanced hematological malignancy in their terminal stage from a phenomenological perspective.

Methods

To collect and analyze data, a qualitative interpretive design was employed, using a phenomenological approach. The study involved in-depth interviews with ten participants aged between 36 and 76 years, utilizing an unstructured approach.

Results

The study's analysis revealed two primary themes that emerged from the participants' experiences of reaching the terminal stage of illness: "Pain, Suffering, and Distress" and "Spiritual Coping." The first theme encompassed physical and emotional pain, suffering, and distress, while the second theme centered on the participants' spiritual coping mechanisms. These coping mechanisms included seeking comfort in religious practices, relying on spiritual support from family and friends, and finding solace in their beliefs and faith.

Conclusion

Patients with hematological malignancies in their terminal stages experience significant physical and psychosocial suffering. While they require support to cope with their daily struggles, their experiences often go unnoticed, leading to disappointment and a loss of dignity. It is critical for healthcare providers to acknowledge these patients' needs and provide more organized and effective care as they approach the end of life, ensuring they receive the necessary support to achieve a peaceful death. This approach can help maintain the patient's comfort and dignity, which is of utmost importance in the terminal stages of illness.
Study of real-world optimization problems using advanced Nature Inspired Algorithms (NIA) discovered from 2019 to 2022
Authors: Rani Rekha , Jain Sarika , Garg Harish 
Published: April 2023

Abstract
The nature inspired algorithm (NIA) is a very essential research area that continuously facilitates finding the solution of optimization problems. NIA is one of the metaheuristic algorithm categorizations that have attracted researchers from last few decades. NIA contributes notably by dealing with many large-scale problems and attaining optimal outcomes. In this study, NIA discovered from 2019 to 2022 is listed with a brief description. The major objective of this paper is to find some best NIA for finding reasonably better solution of real-world complex optimization problems. Bearing this in mind, we have found eight common engineering problems and analyzed their solution using different NIA algorithms. Our comparative study with bibliographic analysis suggests that there are four algorithms which give us the best result for all mentioned eight engineering problems and gives us an optimal solution. This paper also gives the recent development in NIA and their application in different fields like health care, environment, industrial, commercial, machine learning and smart cities. This will support the new and developing researcher to give a broader view on NIA along with future investigation guidelines.
Ensemble learning of decomposition-based machine learning and deep learning models for multi-time step ahead streamflow forecasting in an arid region
Authors: Yang Linshan , Yu Haijiao , Feng Qi , Barzegar Rahim , Adamowski Jan F , Wen Xiaohu 
Published: April 2023

AbstractAs much as accurate streamflow forecasts are important and significant for arid regions, they remain deficient and challenging. An ensemble learning strategy of decomposition-based machine learning and deep learning models was proposed to forecast multi-time-step ahead streamflow for northwest China’s Dunhuang Oasis. The efficiency and reliability of a Bayesian Model Averaging (BMA) ensemble strategy for 1-, 2-, and 3-day ahead streamflow forecasting was evaluated in comparison with decomposition-based machine learning and deep learning models: (i), a variational-mode-decomposition model coupled with a deep-belief-network model (VMD-DBN), (ii) a variational-mode-decomposition model coupled with a gradient-boosted-regression-tree model (VMD-GBRT), (iii) a complete ensemble empirical mode decomposition with adaptive noise model coupled with a deep belief network model (CEEMDAN-DBN), and (iv) a complete ensemble empirical mode decomposition with adaptive noise model with a gradient boosted regression tree coupled model (CEEMDAN-GBRT). Satisfactory forecasts were achieved with all proposed models at all lead times; however, based on Nash-Sutcliffe coefficient (NSE) values of 0.976, 0.967, and 0.957, the BMA model achieved the greatest accuracy for 1-, 2-, and 3-day ahead streamflow forecasts, respectively. Uncertainty analysis confirmed the reliability of the BMA model in yielding consistently accurate streamflow forecasts. Thus, the BMA ensemble strategy could provide an efficient alternative approach to multi-time-step ahead streamflow forecasting for areas where physically-based models cannot be used due to a lack of land surface data. The application of the BMA model was particularly valuable when the ensemble members gave equivalent satisfactory performances, making it difficult to choose amongst them.
MiRNA-103-3p targets Rab10 to activate the Wnt/β-Catenin signaling pathway to ameliorate corticosterone-induced injury in PC12 cells
Authors: Zhang Ye-Ming , Zhang Yuan-Xiang , Lv Ye-Chao , Liu Xiao-Xu , Fan Rong , Zhang Xin 
Published: April 2023

Abstract
As a key regulatory molecule in neurological disorders, the mechanism by which Rab10 exerts its protective effect in neuronal cells in depression is currently unknown. This research aimed to explore the function and mechanism of action of Rab10, a gene associated with neuroprotection, by using an in vitro model of depression. PC12 cells induced by corticosterone (CORT) were used to simulate depression in vitro. The viability of PC12 cells was detected using a CCK-8 assay, and the interaction between miRNA-103-3p and Rab10 was confirmed by bioinformatics combined with double luciferase and RNA Binding Protein Immunoprecipitation (RIP) experiments. The level of miRNA-103-3p and Rab10 were detected using a quantitative PCR assay. The protein contents of Rab10, BDNF, CREB, P62, Beclin-1, Wnt3a, GSK3β, phosphorylated (p)-GSK3β, and β-catenin were detected by western blotting. The results indicated that the content of Rab10 was downregulated in CUMS rats and CORT-induced PC12 cells. Bioinformatics combined with double luciferase and RIP experiments showed that miRNA-103-3p targeted Rab10. Overexpression of Rab10 or silencing of miRNA-103-3p in CORT-induced PC12 cells activated the Wnt/β-catenin signaling pathway, upregulated the contents of BDNF, CREB, and Beclin-1, but downregulated the expression of P62 protein, whereas silencing Rab10 based on silencing miRNA-103-3p reversed the effect of miRNA-103-3p. Overall, our data indicated that miRNA-103-3p targeted Rab10 to activate the Wnt/β-catenin signaling pathway to increase cellular nerve plasticity and promote autophagy, thus resisting CORT-induced damage to PC12 cells.
Wenyang Yiqi Formula improves Na + /H + ion transport by inhibiting NHE3 via activation of gastrin/CCKBR pathway
Authors: Wu Bensheng , He Zongqi , Wang Xiaopeng , Zhou Qing 
Published: April 2023

Abstract
Background: STC is a common digestive disorder and WYF is a Chinese medicine used to treat it. NHE3 is a protein that helps absorb sodium ions and its inhibition has been linked to various diarrheal diseases. There is little research on the effects of WYF on NHE expression and the treatment of STC, and the mechanism behind it is not understood.
Objective: This study aimed to investigate the effects of the WYF on Na+/H+ ion transport in vivo and in vitro and to uncover the mechanism of the WYF in treating STC.
Methods: The effectiveness of WYF in treating STC was tested on rats with induced STC and Caco-2 cells in a laboratory setting. The study compared the impact of WYF on several factors, including the rate of intestinal transit, colon tissue pathology, characteristics of feces, and stool volume among five groups (n=6/group). The researchers also evaluated the effects of WYF on cell viability, NHE3 activity and expression, and markers in two signaling pathways (gastrin/CCKBR and PI3K/PLC/PKC).
Results: WYF improved the rate of intestinal transit and colon tissue pathology in STC rats, and reduced cell viability and NHE3 activity and expression in Caco-2 cells. The concentration of gastrin and the level of CCKBR increased with WYF treatment, while NHE3 activity had opposite trends in response to WYF and the sh-CCKBR group. Adding gastrin reversed these effects in the sh-CCKBR group. The activity of NHE3 was decreased in the WYF (20%)+gastrin (300 nmol) group, but significantly upregulated in the sh-CCKBR group with or without serum containing 20% WYF, which was reversed after adding gastrin. The ratios of p-PI3K to PI3K, p-PLC to PLC, and p-PKC to PKC in the serum containing 20% WYF were significantly increased, but decreased in the LY294002 group. After adding serum containing WYF, the reduction of these ratios was reversed. The activity of NHE3 had opposite trends to the ratios of p-PI3K to PI3K, p-PLC to PLC, and p-PKC to PKC.
Conclusion: The WYF can be used to treat STC, possibly by improving Na+/H+ ion transport through inhibiting NHE3, activating the gastrin/CCKBR pathway, and PI3K/PLC/PKC-dependent pathways.
Tobacco control measures in India: A Scoping Review Protocol
Authors: Mahapatra Biswajit , Khatoon Sajda , Bhattacharya Paramita , Janakiram Chandrashekar , Karuveettil Vineetha , John Denny , Moinudeen Syed Abdul Khader , Mukherjee Nirmalya 
Published: April 2023

Abstract
Objective: The goal of this scoping review is to identify tobacco control interventions and to cover all aspects of tobacco control strategies in the Indian context.
Introduction: Tobacco use and its dependence are now treated as global epidemics and are a significant public health problem in India. Tobacco control is a top priority, both in terms of public health and poverty alleviation. Despite tobacco control policies, various tobacco products are still used in India. Previous studies lacked data on aspects of bidi smoking and smokeless tobacco (SLT) use that are more relevant in the Indian context.
Inclusion criteria: This review will consider all peer-reviewed articles and grey literature published in English language across all age groups, any form of tobacco use, and intervention related tobacco control focused on India.
Methods: The JBI methodology for scoping reviews will be used for this scoping review. Cochrane Central (Wiley), MEDLINE (PubMed), SCOPUS (Elsevier), Embase (Elsevier), Web of Science (Clarivate), PyscINFO (EBSCO), Ovid (MEDLINE) and Web of Science (Clarivate), will be systematically searched, and a search strategy from PubMed (MEDLINE) is presented in Appendix I. The titles and abstracts of peer-reviewed and grey literature will be screened by two independent reviewers. After the final selection, the full-text screening will also be done by the reviewers. A data extraction sheet will be created using the standardised data extraction tools in JBI SUMARI and presented in Appendix II. Findings will be provided as a narrative summary with supporting tables and diagrams, on tobacco control interventions in India.
Modelling monthly trends in sunshine hours for the United Kingdom and its regions
Authors: Mills Terence C. 
Published: April 2023

Abstract

Since 2019 the U.K. Met Office has provided monthly observations, beginning in 1919, on hours of sunshine for the U.K. and its regions. Time series analyses of these data are reported in this paper, using a deterministic monthly trends model. For the U.K. as a whole, winter trend sunshine hours have increased by 23% from 1919 to 2022 and spring trend hours have increased by 12%. Summer and autumn trend sunshine hours, on the other hand, have increased by only 3% and 7% respectively. Consistent with this, trend increases have been significant for the months of November, December, January, and February and also for April and July, but June has seen a significant decline in trend sunshine hours. Analysis of the regional data reveals a rich pattern of trend behaviours. The winter months have typically seen the largest increase in trend sunshine hours, the summer months the smallest, with Northern Ireland and the Scottish regions all experiencing falls in trend sunshine in June. The eastern regions have generally seen the largest increases in trend sunshine hours, often being associated with quadratic trends, the western and outlying regions the smallest.
An Update on Parkinson’s Disease and its Neurodegenerative
Counterparts
Authors: Adam Hussaini , Gopinath Subash C.B. , Arshad M.K. Md , Adam Tijjani , Subramaniam Sreeramanan , Hashim Uda 
Published: April 2023

Introduction:
Neurodegenerative disorders are a group of diseases that cause
nerve cell degeneration in the brain, resulting in a variety of symptoms and are not treatable
with drugs. Parkinson's disease (PD), prion disease, motor neuron disease (MND),
Huntington's disease (HD), spinal cerebral dyskinesia (SCA), spinal muscle atrophy (SMA),
multiple system atrophy, Alzheimer's disease (AD), spinocerebellar ataxia (SCA)
(ALS), pantothenate kinase-related neurodegeneration, and TDP-43 protein disorder are
examples of neurodegenerative diseases. Dementia is caused by the loss of brain and spinal
cord nerve cells in neurodegenerative diseases.

Background:
Even though environmental and genetic predispositions have also been involved
in the process, redox metal abuse plays a crucial role in neurodegeneration since
the preponderance of symptoms originates from abnormal metal metabolism.

Method:
Hence, this review investigates several neurodegenerative diseases that may occur
symptoms similar to Parkinson's disease to understand the differences and similarities
between Parkinson's disease and other neurodegenerative disorders based on reviewing
previously published papers.

Results:
Based on the findings, the aggregation of alpha-synuclein occurs in Parkinson’s
disease, multiple system atrophy, and dementia with Lewy bodies. Other neurodegenerative
diseases occur with different protein aggregation or mutations

Conclusion:
We can conclude that Parkinson's disease, Multiple system atrophy, and Dementia
with Lewy bodies are closely related. Therefore, researchers must distinguish
among the three diseases to avoid misdiagnosis of Multiple System Atrophy and Dementia
with Lewy bodies with Parkinson's disease symptoms.
The Applications of 2D Materials for Electrochemical Biosensing, Drug Delivery, and Environmental Monitoring
Authors: Singh Nandita , Gupta Dimpi , Pratap Azad Uday , Kumar Singh Ashish , Kumar Singh Sunil , Singh Suryabhan , Pratap Singh Divya 
Published: April 2023

Abstract:Two-dimensional (2D) nanomaterials (NMs) have diverse mechanical, chemical and op-tical properties due to which they have received a lot of attention in various fields such as biosen-sors, imaging, tissue engineering, drug delivery, etc. A thorough understanding of the synthetic pro-cedure, physical properties and electrochemical properties of 2D materials will be quite useful in the development of novel and high-efficient electrocatalysts for the electroanalytical application of our interest. This review article summarises the synthesis and application of graphene, graphitic carbon nitride, transition metal dichalcogenides and phosphorene for electrochemical biosensing, drug de-livery application and environmental monitoring. Numerous synthetic approaches which have been adopted to synthesize the 2D materials have been covered and discussed. Also, the reasons behind the catalytic activity of various types of 2D materials and their application as electrode modifier for the development of an efficient biosensor for the point-of-care analysis of biomolecule and drug de-livery and environmental monitoring have been discussed in detail. This review article will give valuable information and future insights to the researchers working in the field of biosensor, drug delivery and environmental monitoring. We anticipate that this review may be of significance for the field to understand the properties as well as the electroanalytical applications of 2D materials, especially in biosensing, drug and environmental monitoring.
Multicomponent Reactions Applied to Total Synthesis of Biologically
Active Molecules: A Short Review
Authors: dos Santos Juliana A. , de Castro Pedro P. , de Oliveira Kleber T. , Brocksom Timothy J. , Amarante Giovanni W. 
Published: April 2023

Abstract:
Multicomponent reactions (MCRs) are processes in which three or more starting materials
are combined in the same reaction vessel, forming an adduct that contains all or most of the
atoms of the starting materials. MCRs are one-pot processes that provide attractive advantages for
the total synthesis of target molecules. These reactions allow rapid access to structurally complex
adducts from particularly simple starting materials. Moreover, MCRs are generally intrinsically associated
with principles of green syntheses, such as atom economy, minimization of isolation, and
purification of synthetic intermediates, leading to large solvent economies and avoiding the production
of large amounts of reaction waste. Thus, synthetic routes employing multicomponent reactions
are generally more convergent, economical and often allow higher overall yields. In total synthesis,
the use of MCRs has been mainly applied in the preparation of key advanced intermediates. Progress
in the use of MCRs in total synthesis has been described over the last decades, including not
only classical MCRs reactions (e.g. isocyanide-based transformations), but also non-traditional multicomponent
reactions. Furthermore, reports concerning stereoselective multicomponent transformations
are still scarce and present further development opportunities. This review aims to provide a
general overview of the application of MCRs as key steps in the rapid preparation of structurally
complex derivatives and fine chemicals. In special, some selected examples have been successfully
applied for medicinal purposes. Finally, in some representative cases, either key intermediates formed
during the reaction vessel or corresponding transition states have been disclosed in order to
provide insights into the reaction mechanisms.