bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nasotracheal Microbiota of Nestlings of Parent White storks with Different Foraging Habits in Spain
Authors: Abdullahi Idris Nasir , Juárez-Fernández Guillermo , Höfle Úrsula , Cardona-Cabrera Teresa , Mínguez David , Pineda-Pampliega Javier , Lozano Carmen , Zarazaga Myriam , Torres Carmen 
Published: April 2023

AbstractMigratory storks could be vectors of transmission of bacteria of public health concern mediated by the colonization, persistence and excretion of such bacteria. This study aims to determine genera/species diversity, prevalence, and co-colonization indices of bacteria obtained from tracheal (T) and nasal (N) samples from storks in relation to exposure to point sources through foraging. One-hundred and thirty-six samples from 87 nestlings of colonies of parent white storks with different foraging habits (natural habitat and landfills) were obtained (84 T-samples and 52 N-samples) and processed. Morphologically distinct colonies (up to 12/sample) were randomly selected and identified by MALDI-TOF-MS. About 87.2% of the total 806 isolates recovered were identified: 398 from T-samples (56.6%) and 305 from N-samples (43.4%). Among identified isolates, 17 genera and 46 species of Gram-positive and Gram-negative bacteria were detected, Staphylococcus (58.0%) and Enterococcus (20.5%) being the most prevalent genera. S. sciuri was the most prevalent species from T (36.7%) and N (34.4%) cavities of total isolates, followed by E. faecalis (11.1% each from T and N), and S. aureus [T (6.5%), N (13.4%)]. Of N-samples, E. faecium was significantly associated with nestlings of parent storks foraging in landfills (p = 0.018). S. sciuri (p = 0.0034) and M. caseolyticus (p = 0.032) from T-samples were significantly higher among nestlings of parent storks foraging in natural habitats. More than 80% of bacterial species in the T and N cavities showed 1–10% co-colonization indices with one another, but few had ≥ 40% indices. S. sciuri and E. faecalis were the most frequent species identified in the stork nestlings. Moreover, they were highly colonized by other diverse and potentially pathogenic bacteria. Thus, storks could be sentinels of point sources and vehicles of bacterial transmission across the “One Health” ecosystems.
New Insights on the Palaeo-archaeological Potential of the Niokolo-Koba National Park, Senegal
Authors: Ndiaye Matar , Huysecom Eric , Douze Katja 
Published: April 2023

AbstractThe study of the Palaeolithic in Senegal has made considerable progress in the last decade and has provided a renewed vision of the behavioral evolution of prehistoric populations in West Africa. The cultural trajectories within the region seem to be highly variable and bear witness to strong behavioral dynamics, the mechanisms of which still need to be better understood. However, the number of reliable, dated, and stratified sites, as well as the palaeoenvironmental data providing a context for populations in their palaeolandscapes, is still scarce. In order to provide new and solid data, we conducted new archaeological survey in the Niokolo-Koba National Park in south-central Senegal, aiming at a preliminary identification of Pleistocene and early Holocene sedimentary deposits. Here, we report an overview of the newly discovered industries found in different contexts. Most of the 27 identified sites show surface and out-of-context assemblages, but other sites are stratified and have all the criteria to justify the development of a long-term archaeological, geochronological, geomorphological, and palaeobotanical project. The Niokolo-Koba National Park, through which the Gambia River flows, is characterized by an abundance of sources of knappable material and by well-preserved sedimentary sequences. Therefore, archaeological research in the Niokolo-Koba National Park has the potential to provide major milestones in our understanding of the evolutionary dynamics at work in West Africa during the early periods of occupation of the region.
General and patient-specific seizure classification using deep neural networks
Authors: Massoud Yasmin M. , Abdelzaher Mennatallah , Kuhlmann Levin , Abd El Ghany Mohamed A. 
Published: April 2023

AbstractSeizure prediction algorithms have been central in the field of data analysis for the improvement of epileptic patients’ lives. The most recent advancements of which include the use of deep neural networks to present an optimized, accurate seizure prediction system. This work puts forth deep learning methods to automate the process of epileptic seizure detection with electroencephalogram (EEG) signals as input; both a patient-specific and general approach are followed. EEG signals are time structure series motivating the use of sequence algorithms such as temporal convolutional neural networks (TCNNs), and long short-term memory networks. We then compare this methodology to other prior pre-implemented structures, including our previous work for seizure prediction using machine learning approaches support vector machine and random under-sampling boost. Moreover, patient-specific and general seizure prediction approaches are used to evaluate the performance of the best algorithms. Area under curve (AUC) is used to select the best performing algorithm to account for the imbalanced dataset. The presented TCNN model showed the best patient-specific results than that of the general approach with, AUC of 0.73, while ML model had the best results for general classification with AUC of 0.75.
Flow Reconstruction Around a Surface-Mounted Prism from Sparse Velocity and/or Scalar Measurements Using a Combination of POD and a Data-Driven Estimator
Authors: Lu Shengqi , Papadakis George 
Published: April 2023

AbstractA data-driven algorithm is proposed for flow reconstruction from sparse velocity and/or scalar measurements. The algorithm is applied to the flow around a two-dimensional, wall-mounted, square prism. To reduce the problem dimensionality, snapshots of flow and scalar fields are processed to derive POD modes and their time coefficients. Then a system identification algorithm is employed to build a reduced order, linear, dynamical system for the flow and scalar dynamics. Optimal estimation theory is subsequently applied to derive a Kalman estimator to predict the time coefficients of the POD modes from sparse measurements. Analysis of the flow and scalar spectra demonstrate that the flow field leaves its footprint on the scalar, thus extracting velocity from scalar concentration measurements is meaningful. The results show that remarkably good reconstruction of the flow statistics (Reynolds stresses) and instantaneous flow patterns can be obtained using a very small number of sensors (even a single scalar sensor yields very satisfactory results for the case considered). The Kalman estimator derived at one condition is able to reconstruct with acceptable accuracy the flow fields at two nearby off-design conditions. Further work is needed to assess the performance of the algorithm in more complex, three-dimensional, flows.
IGF2BP2 promotes lncRNA DANCR stability mediated glycolysis and affects the progression of FLT3-ITD + acute myeloid leukemia
Authors: Wu Shenghao , Chi Changwei , Weng Shanshan , Zhou Wenjin , Liu Zhen 
Published: April 2023

AbstractInternal tandem duplication (ITD) is the most common type of FLT3 mutation (FLT3-ITD), accounting for about 25% of AML patients. The expression of DANCR in FLT3-ITD AML had not been paid attention to, and whether its regulatory relationship with IGF2BP2 can affect the progression of FLT3-ITD AML was unclear. Our study sought to verify the biological role of IGF2BP2 as an m6A reading protein in FLT3-ITD AML. To further explore the role and mechanism of DANCR in AML, and provide a basis for the screening of biomarkers and the development of targeted drugs. The results show that IGF2BP2 was upregulated in FLT3-ITD+ AML patients and cells. Si-IGF2BP2 could inhibit the proliferation, glycolytic and promote the apoptosis in MV4-11 cells. IGF2BP2 could promote the DANCR RNA stability. This discovery will provide new horizons for early screening and targeted therapy of FLT3-ITD+ AML.
Tamoxifen pharmacokinetics and pharmacodynamics in older patients with non-metastatic breast cancer
Authors: Souwer E. T. D. , Sanchez-Spitman A. , Moes D. J. A. R. , Gelderblom H. , Swen J. J. , Portielje J. E. A. , Guchelaar H. J. , van Gelder T. 
Published: April 2023

Abstract
Background
We aimed to study the pharmacokinetics and -dynamics of tamoxifen in older women with non-metastatic breast cancer.

Methods
Data for this analysis were derived from the CYPTAM study (NTR1509) database. Patients were stratified by age (age groups < 65 and 65 and older). Steady-state trough concentrations were measured of tamoxifen, N-desmethyltamoxifen, 4-hydroxy-tamoxifen, and endoxifen. CYP2D6 and CYP3A4 phenotypes were assessed for all patients by genotyping. Multiple linear regression models were used to analyze tamoxifen and endoxifen variability. Outcome data included recurrence-free survival at time of tamoxifen discontinuation (RFSt) and overall survival (OS).

Results
668 patients were included, 141 (21%) were 65 and older. Demographics and treatment duration were similar across age groups. Older patients had significantly higher concentrations of tamoxifen 129.4 ng/ml (SD 53.7) versus 112.2 ng/ml (SD 42.0) and endoxifen 12.1 ng/ml (SD 6.6) versus 10.7 ng/ml (SD 5.7, p all < 0.05), independently of CYP2D6 and CYP3A4 gene polymorphisms. Age independently explained 5% of the variability of tamoxifen (b = 0.95, p < 0.001, R2 = 0.051) and 0.1% of the variability in endoxifen concentrations (b = 0.45, p = 0.12, R2 = 0.007). Older patients had worse RFSt (5.8 versus 7.3 years, p = 0.01) and worse OS (7.8 years versus 8.7 years, p = 0.01). This was not related to differences in endoxifen concentration (HR 1.0, 95% CI 0.96–1.04, p = 0.84) or CYP polymorphisms.

Conclusion
Serum concentrations of tamoxifen and its demethylated metabolites are higher in older patients, independent of CYP2D6 or CYP3A4 gene polymorphisms. A higher bioavailability of tamoxifen in older patients may explain the observed differences. However, clinical relevance of these findings is limited and should not lead to a different tamoxifen dose in older patients.
The Impact of CEOs’ Personal Traits on Organisational Performance: Evidence from Faith-Based Charity Organisations
Authors: Melis Andrea , Nawaz Tasawar 
Published: April 2023

AbstractThis study examines whether and how a CEO’s personal traits (gender, altruism, age, and founder) influence organizational performance. Building upon upper echelons theory, this study develops a conceptual framework that gives explicit recognition to how the institutional environment surrounding the CEOs shapes their characteristics, which, in turn, are reflected in the different organizational strategies and performance. This study moves beyond the existing focus on for-profit corporations and conducts the empirical analysis on a novel, hand-collected, longitudinal dataset of 1342 firm-year observations of 128 faith-based charity organizations operating in a major developing, Muslim-majority country in the period 1996–2019. This study reveals that those faith-based charity organizations led by CEOs with specific personal traits (woman, altruistic, young, and founder) exhibit better organizational performance. Importantly, CEOs’ personal traits, however, do not have a uniform, systematic effect; their effect is generally strengthened when the CEO is also the founder of the faith-based charity organization, given the greater latitude of managerial discretion that a CEO has in managing the organization. Our findings have important implications for individual charity organizations; their board of directors; and their stakeholders, in particular the communities they serve, as well as the whole society where they operate.
Are automated static analysis tools worth it? An investigation into relative warning density and external software quality on the example of Apache open source projects
Authors: Trautsch Alexander , Herbold Steffen , Grabowski Jens 
Published: April 2023

AbstractAutomated Static Analysis Tools (ASATs) are part of software development best practices. ASATs are able to warn developers about potential problems in the code. On the one hand, ASATs are based on best practices so there should be a noticeable effect on software quality. On the other hand, ASATs suffer from false positive warnings, which developers have to inspect and then ignore or mark as invalid. In this article, we ask whether ASATs have a measurable impact on external software quality, using the example of PMD for Java. We investigate the relationship between ASAT warnings emitted by PMD on defects per change and per file. Our case study includes data for the history of each file as well as the differences between changed files and the project in which they are contained. We investigate whether files that induce a defect have more static analysis warnings than the rest of the project. Moreover, we investigate the impact of two different sets of ASAT rules. We find that, bug inducing files contain less static analysis warnings than other files of the project at that point in time. However, this can be explained by the overall decreasing warning density. When compared with all other changes, we find a statistically significant difference in one metric for all rules and two metrics for a subset of rules. However, the effect size is negligible in all cases, showing that the actual difference in warning density between bug inducing changes and other changes is small at best.
Strange Tunes—Acoustic Variation and Character Displacement in a Tarsier Hybrid Zone
Authors: Bohr Yvonne E.-M. B. , Purbatrapsila Azhari , Perwitasari-Farajallah Dyah , Ganzhorn Jörg U. , Merker Stefan 
Published: April 2023

AbstractNatural hybridization provides valuable insights into evolutionary processes, such as speciation and the forces driving or hindering it. Sulawesi tarsiersTarsius dentatusandT. larianghybridize within a limited area, suggesting selection against hybrids. Their species- and sex-specific duet songs might serve as a premating barrier in sympatry, especially if differences are strengthened by character displacement. Individuals of mixed origin might face disadvantages if they inherit intermediate song traits. To shed light on the processes shaping this hybrid zone, we analysed 55 duet songs from within and outside the zone. For females and males, we identified temporal and frequency-related parameters that differ between species. We inspected hybrid songs for intermediate characteristics and analysed purebred songs for character displacement in sympatry. Female hybrid songs (N = 2) were intermediate in four to five of six parameters; interpretation of male hybrid songs (N = 2) was inconclusive, because only two parameters were reliably quantifiable. There was no character displacement in female songs in sympatry (N = 11) compared with monospecific areas (N = 17). In male songs, interspecific differences in note rate were significantly larger within the hybrid zone (N = 8) compared with outside (N = 13). Intermediate song traits indicate inheritance and may disadvantage hybrids during mate choice. Character displacement in male songs is consistent with female mate choice, because females should opt for unmistakable signals to avoid costly hybridization. Our findings thus suggest that duet songs ofT. lariangandT. dentatusplay an important role in limiting this hybrid zone.
Concise review of genus Lessonia Bory
Authors: Nardelli Allyson E. , Visch Wouter , Wright Jeffrey T. , Hurd Catriona L. 
Published: April 2023

Abstract
Lessonia (order Laminariales) is a kelp genus restricted to the temperate southern hemisphere, where species form dense forests from the low intertidal to 25 m depth at wave exposed sites. Lessonia spp. are among the most harvested kelps globally due to their importance in providing raw materials for food, cosmetics, bioactive and biomedical industries. Over-harvesting of natural beds can negatively affect Lessonia populations and the many species that depend on these habitats, including commercially important fish and molluscs, but good harvest management plans reduce these impacts on natural Lessonia stocks. However, the increasing demand for raw materials will likely only be met by aquaculture for which Lessonia shows high potential in pilot scale studies undertaken in Chile, New Zealand, and Australia. In this concise review, we highlight the current knowledge of Lessonia spp. taxonomy and distribution, life history, ecology and ecosystem services, wild harvest, aquaculture, and commercial applications. We discuss future research directions.
Quality of Interactions, Children’s Psychological Adjustment and Parental Stress in Foster Families: the Mediating Role of Parental Sense of Competence
Authors: Molano Nuria , León Esperanza , Jiménez-Morago Jesús M. , Camacho Carlos 
Published: April 2023

AbstractFoster children’s emotional and behavioral difficulties are often a challenge for foster caregivers, who may experience reduced feelings of competence in their parental role, as well as increased levels of parental stress. In turn, these difficulties can negatively affect the quality of the interactions between them. In the present work, our first objective was to analyze the quality of the interactions between 49 Spanish foster children aged 4–9 years and their main caregivers, and its relationship with some variables, which were studied as potential predictors: the caregivers’ parental stress and sense of competence, the children’s psychological adjustment difficulties, and the children and caregivers’ socio-demographic profile. We assessed caregiver-child interactions using an observational task (Co-Construction Task). The caregivers completed standardized questionnaires regarding their parental stress (Parenting Stress Index-Short Form; PSI-SF), parental sense of competence (Parenting Sense of Competence Scale; PSOC), and foster children’s psychological adjustment difficulties (Strengths and Difficulties Questionnaire; SDQ). Also, we obtained their socio-demographic information through the families’ caseworkers. The second objective was to examine whether caregivers’ parental sense of competence mediated the relationship between children’s psychological adjustment difficulties and caregivers’ parental stress. Results concerning our first objective showed that caregivers’ parental stress and children’s age were significant predictors of the quality of caregiver-child interactions. As for the second objective, our mediation model indicated that parental sense of competence partially mediated the relationship between children’s psychological adjustment difficulties and caregivers’ parental stress. Lastly, we comment on some practical implications based on our results, which point to the need to include both self-report and observational measures when assessing and intervening with foster families.
Slow negative feedback enhances robustness of square-wave bursting
Authors: John Sushmita Rose , Krauskopf Bernd , Osinga Hinke M. , Rubin Jonathan E. 
Published: April 2023

AbstractSquare-wave bursting is an activity pattern common to a variety of neuronal and endocrine cell models that has been linked to central pattern generation for respiration and other physiological functions. Many of the reduced mathematical models that exhibit square-wave bursting yield transitions to an alternative pseudo-plateau bursting pattern with small parameter changes. This susceptibility to activity change could represent a problematic feature in settings where the release events triggered by spike production are necessary for function. In this work, we analyze how model bursting and other activity patterns vary with changes in a timescale associated with the conductance of a fast inward current. Specifically, using numerical simulations and dynamical systems methods, such as fast-slow decomposition and bifurcation and phase-plane analysis, we demonstrate and explain how the presence of a slow negative feedback associated with a gradual reduction of a fast inward current in these models helps to maintain the presence of spikes within the active phases of bursts. Therefore, although such a negative feedback is not necessary for burst production, we find that its presence generates a robustness that may be important for function.
Pulmonary vein isolation by visually guided laser balloon ablation: single-center 5-year follow-up results
Authors: Koopman Pieter , Bekelaar Thalia , Schurmans Joris , Phlips Thomas , Dilling-Boer Dagmara , Vijgen Johan 
Published: April 2023

Abstract

Background

Visually guided laser balloon (VGLB) ablation is a balloon-based treatment for atrial fibrillation (AF) that uses a titratable laser energy source to perform pulmonary vein isolation (PVI), allowing for real-time visualization of target tissue and ablation lesions through an endoscopic camera. Few long-term data on this technique are currently available. This report presents acute efficacy, procedural data, complication rates, and long-term AF-free survival up to 5 years post-ablation.

Methods
In this single-center, retrospective, observational report, 152 patients (72.4% male, mean age 60.6 ± 9.7 years, 62.5% paroxysmal AF, 598 pulmonary veins in total) treated with the first-generation VGLB system between 2014 and 2016 were included for analysis. AF ablation consisted of PVI only.

Results
Acute PVI was achieved in 98.2% of veins, with first-pass isolation in 92.5%. Procedure duration of 129 min [IQR 113–150], fluoroscopy time of 15 min [IQR 11–20], and dose area product of 5016 mGy·cm2 [IQR 3603–8711] were recorded. During a median follow-up of 51 months [IQR 45–57], 74.3% of patients remained free of AF (78.8% for paroxysmal and 65.3% for persistent AF, p = 0.108). Freedom of AF at 1, 2, 3, and 4 years follow-up was 88.2%, 82.2%, 78.9%, and 74.8%, respectively. PV reconnections were identified in only 46.9% of redo procedures. The median number of PV reconnections during redo procedures was 0 [IQR 0–2]. Anti-arrhythmic drug use was significantly reduced after ablation (p < 0.001). The most commonly reported complications were minor vascular complications (4.6%) and transient phrenic nerve paralysis (3.3%).

Conclusions
First-generation VGLB ablation demonstrated high acute isolation rates, reasonable procedure times and low complication rates. Long-term freedom from AF was 78.8% for paroxysmal AF and 65.3% for persistent AF, performing PVI only.