bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reading the Late Plays
Authors: Balázs Zsuzsanna 
Published: July 2023

Abstract
This chapter considers the intersections of violence/power and sexual desire in three of Yeats’s late plays—The Cat and the Moon (1926), The King of the Great Clock Tower (1935), and A Full Moon in March (1935)—with a focus on sadomasochism and what has been described as ‘the ritual exchange of power’. It contends that through theatrical representations of sadomasochistic attachments based on reversible power, Yeats’s late drama reveals the systemic failures of normative distributions of power, gender, and sexual roles, and proposes alternatives. It discusses Yeats’s unconventional relationship with sexuality, his increasing interest in corporeality, and the importance of literary representations of sadomasochism. It goes on to evaluate, from a dramaturgical approach, the potentials of the scripts to demonstrate that Yeats’s plays convey crucial messages about power, the body, and difference for contemporary audiences. These plays feature clashes between the unruly forces of seduction and the normative force of power and production. Their protagonists are defiant social outcasts, whose clash with power paradoxically earns them temporary visibility and authority. They fail to meet normative standards of bodily being, which becomes an act of resistance, since the characters representing the power of production (the Saint in The Cat and the Moon, the King in The King of the Great Clock Tower, and the Queen in A Full Moon in March) are obsessed with bodily perfection. These master–slave relationships appear as sadomasochistic mostly due to their reversibility, which also renders them an element of excitement and playfulness.
In situcryo-electron tomography of β-amyloid and tau in post-mortem Alzheimer’s disease brain
Authors: Gilbert Madeleine A. G. , Fatima Nayab , Jenkins Joshua , O’Sullivan Thomas J. , Schertel Andreas , Halfon Yehuda , Morrema Tjado H. J. , Geibel Mirjam , Radford Sheena E. , Hoozemans Jeroen J. M. , Frank René A. W. 
Published: July 2023

ABSTRACTA defining pathological feature of most neurodegenerative diseases is the assembly of proteins into amyloid that form disease-specific structures. In Alzheimer’s disease (AD) this is characterised by the deposition of amyloid-β (Aβ) and tau with AD-specific conformations. Thein situstructure of amyloid in the human brain is unknown. Here, using cryogenic fluorescence microscopy (cryoFM)-targeted cryo-sectioning, cryo-focused ion beam scanning electron microscopy (cryoFIB-SEM) liftout and cryo-electron tomography (cryoET), we determined the in-tissue structure of β-amyloid and tau pathology in fresh post-mortem AD donor brain. β-amyloid plaques contained a mixture of fibrils and protofilaments arranged in parallel arrays and lattice-like structures, some of which were branched. Extracellular vesicles, extracellular droplets and open lipid bilayer sheets defined non-amyloid constituents of amyloid plaques. In contrast, tau inclusions were characterised by clusters of unbranched filaments. Subtomogram averaging of filaments within each cluster revealed distinct structures including variably twisted paired helical filaments (PHF) and chronic traumatic encephalopathy (CTE)-like tau filaments that were situated ∼1 μm apart within two microscopic regions of pathology. Filaments within a cluster were similar to each other, but different between clusters, showing that fibril heterogeneity is spatially organised and influenced by the subcellular tissue environment. Thein situstructural approaches outlined here for targeting specific proteins within human donor tissues have applications to a broad range of neurodegenerative diseases.
Numerical analysis of unstable propagation of three-dimensional parallel hydraulic fractures induced by interferences of adjacent perforation clusters and thermal diffusion
Authors: Wang Yongliang 
Published: July 2023

PurposeThe purpose of this study is to investigate the unstable propagation of parallel hydraulic fractures induced by interferences of adjacent perforation clusters and thermal diffusion. Fracture propagation in the process of multistage fracturing of a rock mass is deflected owing to various factors. Hydrofracturing of rock masses in deep tight reservoirs involves thermal diffusion, fluid flow and deformation of rock between the rock matrix and fluid in pores and fractures.Design/methodology/approachTo study the unstable propagation behaviours of three-dimensional (3D) parallel hydraulic fractures induced by the interferences of adjacent perforation clusters and thermal diffusion, a 3D engineering-scale numerical model is established under different fracturing scenarios (sequential, simultaneous and alternate fracturing) and different perforation cluster spacings while considering the thermal-hydro-mechanical coupling effect. Stress disturbance region caused by fracture propagation in a deep tight rock mass is superimposed and overlaid with multiple fractures, resulting in a stress shadow effect and fracture deflection.FindingsThe results show that the size of the stress shadow areas and the interaction between fractures increase with decreasing multiple perforation cluster spacing in horizontal wells. Alternate fracturing can produce more fracture areas and improve the fracturing effect compared with those of sequential and simultaneous fracturing. The larger the temperature gradient between the fracturing fluid and rock matrix, the stronger the thermal diffusion effect, and the effect of thermal diffusion on the fracture propagation is significant.Originality/valueThis study focuses on the behaviours of the unstable dynamic propagation of 3D parallel hydraulic fractures induced by the interferences of adjacent perforation clusters and thermal diffusion. Further, the temperature field affects the fracture deflection requires could be investigated from the mechanisms; this paper is to study the unstable propagation of fractures in single horizontal well, which can provide a basis for fracture propagation and stress field disturbance in multiple horizontal wells.
Investigating teacher talk in EAP and EGP classes: In pursuit of communicative features
Authors: Ghajarieh Amir , Mirzabeigi Nasim 
Published: July 2023

PurposeThis study aims to explore the communicative features of teacher talk in English for General Purposes (EGP) vs. English for Academic Purposes (EAP) classes in Iranian contexts based on the Self-Evaluation Teacher Talk (SETT) framework.Design/methodology/approachFor the purposes of this study, EAP and EGP classes run by three language instructors and three content instructors were observed and interviews with teacher participants were conducted. The data were analyzed by content analysis, and emerging overarching themes were recorded.FindingsThe findings of this study indicate that the translation of texts into Persian was the dominant theme in classes run by content instructors who were less aware of the communicative features of teacher talk. However, one of the content instructors who was familiar with the communicative features of teacher talk as well as general language instructors were found to be highly aware of the potential of their teacher talk to encourage communication in his classes. The innovative and communicative features in the language/content instructor suggest the importance of teacher agency in bringing change in education at the micro-level. This study has implications for various agencies involved in teaching EAP, EGAP and English for Specific Purposes (ESAP), raising awareness regarding the communicative features of teacher talk as a driving force leading learners and teachers to more communicative opportunities in language classrooms. The findings suggest that teacher talk is an essential component of classroom discourse, shaping students' linguistic and academic development, and that teacher agency is crucial in promoting communicative opportunities in language education. To boost communication, the authors recommend translanguaging with a focus on both communication and optimal use of the mother tongue in EAP classes.Originality/valueThere is little empirical evidence on the communicative aspects of teacher talk in higher education. This study can inspire more parallel research on EAP settings in higher education with a focus on communication and teacher talk features.
Relationships among school principals' work values, organisational climate and organisational adaptation: Taiwan's 2018 TALIS data
Authors: Lin Yi Hua , Chen Chien Chih 
Published: July 2023

PurposeThe educational environment in Taiwan's primary and secondary schools is becoming increasingly diverse and complex. This study examined the relationship between primary and secondary school principals' working values, organisational climate and organisational adaptation.Design/methodology/approachData were collected from the third Teaching and Learning International Survey (TALIS), which targeted 401 principals in Taiwan's primary and secondary schools, conducted in 2018 by the Organisation for Economic Co-operation and Development (OCED). In this study, a structural equation model was constructed.FindingsThe results indicated that primary and secondary school principals generally had positive work values, and their schools' organisational climate and adaptation were positive. In addition, the work values, organisational climate and organisational adaptation models showed good fit for a variety of potential variables. Furthermore, the organisational climate had a mediating effect that strengthened the principals' work values and was a major factor in enhancing organisational adaptation. The results suggest that in addition to principals' positive work values, fostering a cooperative organisational climate—such as the perceived level of support from supervisors and the environment—is essential to enhance schools' organisational adaptation.Originality/valueThe principal's work value has a profound impact on the creation of a school's organisational atmosphere, the cohesion of members' consensus and the organisation's contingency decision-making in response to the external environment. This study adduces more diverse recommendations for the development of school affairs.
Educating the Rational Emotions: An Affective Response to Extremism
Authors: D'Olimpio Laura 
Published: July 2023

AbstractEducating against extremism doesn't just involve seeking to prevent individuals from becoming extremists or radicalized, although that, of course, is a significant concern. There is also an important role for education in teaching the rest of us, the general populace, the best way to react and respond when we learn of a terrorist attack or consider the potential risk of violent extremism in our community, or even worldwide, given we are connected globally via technology. In this article, Laura D'Olimpio argues that educators have a central role to play in teaching young people to respond to the news of violent extremism and the worry about terrorists and terrorism in ways that support our sense of community and personal well‐being. Among the ways in which educators may support such aims is by educating the emotions. There are practical and moral reasons to temper our fearful reactions, and it is in our best interest to educate pupils to avoid allowing fear of terrorists or violent extremism to interfere with their daily lives and actions. D'Olimpio claims that our best response to extremism, both representationally and practically, is to refuse to be terrified. By not being overwhelmed by fear or altering our day‐to‐day activities, we not only better support a well‐functioning democracy and our own happiness or flourishing, but we also disempower rather than empower extremists.
Development and psychometric properties of the Serbian version of the Orofacial Esthetic Scale
Authors: Kostić Milena , Ignjatović Aleksandra , Gligorijević Nikola , Jovanović Marija , Đorđević Nadica S. , Đerlek Amar , Igić Marko 
Published: July 2023

AbstractObjectiveThe aim of the study was to develop the Serbian language version of the Orofacial Esthetic Scale questionnaire (OES SERB) and to evaluate its psychometric properties.MethodsThe study included 226 subjects – 110 dental students and 116 patients (the validation sample). The students answered all the questions individually with the help of supervisors, whereas the prosthodontic patients were interviewed by the same trained dentist. The reliability and validity of the questionnaire were assessed.ResultsInternal consistency of the OES‐SERB was considered satisfactory (Cronbach's alpha 0.92, inter‐item correlation coefficient ranged between 0.735 and 0.898). The construct validity of the OES was proved using exploratory factor analysis, which confirmed the one‐ dimensional model of the OES‐SERB that assumed 66.549% of the variance. The Bartlett's test of sphericity was 1380.134 (df = 28, p < 0.001) and the Kaiser‐Meyer‐Olkin (KMO) test was 0.900. The total score was statistically significantly different between students and patients (p < 0.001), which confirmed the discriminant validity.ConclusionThe Serbian version of the OES, adapted to the cultural setting of the Republic of Serbia, has exhibited excellent psychometric properties and has been confirmed as a one‐dimensional tool for self‐assessment of the appearance of the orofacial region.Clinical SignificanceThe Serbian version of the OES has good psychometric properties and is a valuable instrument for self‐assessment of the appearance of the orofacial region.
Complement components C3b and C4b as potential reliable site‐specific diagnostic biomarkers for periodontitis
Authors: Huang Ren‐Yeong , Tseng Fang‐Yi , Cheng Chia‐Dan , Van Dyke Thomas E , Sung Cheng‐En , You Jhong‐Jhe , Weng Pei‐Wei , Shieh Yi‐Shing , Cheng Wan‐Chien 
Published: July 2023

AbstractObjectiveThis study aimed to investigate the correlation between the expression levels of C3b and C4b in human gingival tissue (GT) and gingival crevicular fluid (GCF) and disease severity in human periodontitis and to determine whether C3b and C4b are significant site‐specific complementary diagnostic markers for periodontitis.BackgroundA variety of biomarkers that have potential for informing diagnoses of periodontitis have been proposed. The complement components C3b and C4b were found to be positively correlated with disease severity. The therapeutic effect of targeting C3b and C4b on inflammatory bone loss in experimental periodontitis models has been studied. However, studies on the diagnostic potential of the gingival C3b and C4b expression levels for periodontitis are scarce.MethodsThe expression levels of C3b and C4b in the GT and GCF were investigated via immunohistochemistry and enzyme‐linked immunosorbent assay, respectively. The correlation between the expression levels of C3b and C4b and disease severity with probing depth as well as the clinical attachment level were determined. To evaluate the diagnostic accuracy of the C3b and C4b expression levels at the periodontitis sites, the receiver operating characteristic (ROC) curve, cut‐off point, area under the ROC curve, sensitivity, and specificity were analyzed.ResultsThe expression levels of C3b and C4b in human GT and GCF were significantly positively correlated with periodontitis severity. The expression levels of combined C3b + C4b in the GT can significantly differentiate the disease status at the tissue level (p < .0001). Similarly, the expression levels of C3b + C4b in GCF can statistically distinguish periodontitis sites from healthy ones (p < .0001).ConclusionsLocally deposited C3b and C4b were positively correlated with periodontitis severity and recognized as site‐specific diagnostic biomarkers for clinicopathological features in periodontitis. The association between the C3b and C4b network and periodontitis may be further understood and provide a basis for the development of novel screening as well as diagnostic and therapeutic strategies for periodontitis.
MID-ESM: An Adaptive Median-Based Ensemble of Surrogate Models
Authors: Li Jianji , Zhang Shuai , Liang Pengwei , Lai Xiaonan , Song Xueguan 
Published: July 2023

Abstract
Along with the development of surrogate models, there is a growing need to use surrogate models instead of computationally intensive simulations to estimate real system responses. Compared with individual surrogate models, the ensemble of surrogate models is gradually drawing more attention due to its better applicability and robustness. Thus, this paper proposes an adaptive median-based ensemble of surrogate models (MID-ESMs). At first, construct a reference model using the median of the predicted values of several surrogate models. Then an adaptive weight ensemble strategy is proposed based on the reference model to integrate global trends and local features. Thirty test functions and a practical engineering case are used to evaluate the model performance. In addition, this paper investigates the effect of homoscedasticity noise and test functions of different dimensions on the proposed model. The results demonstrate that MID-ESM has higher accuracy and robustness than individual surrogate models and other ensembles of surrogate models, offering better applicability in engineering problems.
A Tri-Objective Method for Bi-Objective Feature Selection in Classification
Authors: Jiao Ruwang , Xue Bing , Zhang Mengjie 
Published: July 2023

Abstract
Minimizing the number of selected features and maximizing the classification performance are two main objectives in feature selection, which can be formulated as a bi-objective optimization problem. Due to the complex interactions between features, a solution (i.e., feature subset) with poor objective values does not mean that all the features it selects are useless, as some of them combined with other complementary features can greatly improve the classification performance. Thus, it is necessary to consider not only the performance of feature subsets in the objective space, but also their differences in the search space, to explore more promising feature combinations. To this end, this paper proposes a tri-objective method for bi-objective feature selection in classification, which solves a bi-objective feature selection problem as a tri-objective problem by considering the diversity (differences) between feature subsets in the search space as the third objective. The selection based on the converted tri-objective method can maintain a balance between minimizing the number of selected features, maximizing the classification performance, and exploring more promising feature subsets. Furthermore, a novel initialization strategy and an offspring reproduction operator are proposed to promote the diversity of feature subsets in the objective space and improve the search ability, respectively. The proposed algorithm is compared with five multiobjective-based feature selection methods, six typical feature selection methods, and two peer methods with diversity as a helper objective. Experimental results on 20 real-world classification datasets suggest that the proposed method outperforms the compared methods in most scenarios.
Implications of the COVID-19 Pandemic on Regional Integration in East Africa
Authors: Ramadhani Lupa 
Published: July 2023

Abstract
This article uses the regional response against the Corona Virus Disease (COVID-19) pandemic as a proxy for measuring the depth of integration in the East African Community (EAC). The article probes actions and decisions of the EAC member states in combating the COVID-19 pandemic as a litmus test of strength of supranational institutions. To achieve this, a review of the integration process has been undertaken to appraise of the level of depth of integration, achievements and challenges. It sets out by surveying the theoretical debate on regional integration and pertinent issues of necessity and resistance to regional integration. Ultimately, it wishes to establish whether the COVID-19 pandemic was an opportunity for deepening regional integration or it has served to expose the institutional and policy limitations eroding the pillars of integration.
SNPeffect 5.0: large-scale structural phenotyping of protein coding variants extracted from next-generation sequencing data using AlphaFold models
Authors: Janssen Kobe , Duran-Romaña Ramon , Bottu Guy , Guharoy Mainak , Botzki Alexander , Rousseau Frederic , Schymkowitz Joost 
Published: July 2023

Abstract
Background
Next-generation sequencing technologies yield large numbers of genetic alterations, of which a subset are missense variants that alter an amino acid in the protein product. These variants can have a potentially destabilizing effect leading to an increased risk of misfolding and aggregation. Multiple software tools exist to predict the effect of single-nucleotide variants on proteins, however, a pipeline integrating these tools while starting from an NGS data output list of variants is lacking.

Results
The previous version SNPeffect 4.0 (De Baets in Nucleic Acids Res 40(D1):D935–D939, 2011) provided an online database containing pre-calculated variant effects and low-throughput custom variant analysis. Here, we built an automated and parallelized pipeline that analyzes the impact of missense variants on the aggregation propensity and structural stability of proteins starting from the Variant Call Format as input. The pipeline incorporates the AlphaFold Protein Structure Database to achieve high coverage for structural stability analyses using the FoldX force field. The effect on aggregation-propensity is analyzed using the established predictors TANGO and WALTZ. The pipeline focuses solely on the human proteome and can be used to analyze proteome stability/damage in a given sample based on sequencing results.

Conclusion
We provide a bioinformatics pipeline that allows structural phenotyping from sequencing data using established stability and aggregation predictors including FoldX, TANGO, and WALTZ; and structural proteome coverage provided by the AlphaFold database. The pipeline and installation guide are freely available for academic users on https://github.com/vibbits/snpeffect and requires a computer cluster.