bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dose-dependent changes in real-life affective well-being in healthy community-based individuals with mild to moderate childhood trauma exposure
Authors: Berhe Oksana , Moessnang Carolin , Reichert Markus , Ma Ren , Höflich Anna , Tesarz Jonas , Heim Christine M. , Ebner-Priemer Ulrich , Meyer-Lindenberg Andreas , Tost Heike 
Published: April 2023

Abstract
Background
Childhood trauma exposures (CTEs) are frequent, well-established risk factor for the development of psychopathology. However, knowledge of the effects of CTEs in healthy individuals in a real life context, which is crucial for early detection and prevention of mental disorders, is incomplete. Here, we use ecological momentary assessment (EMA) to investigate CTE load-dependent changes in daily-life affective well-being and psychosocial risk profile in n = 351 healthy, clinically asymptomatic, adults from the community with mild to moderate CTE.

Findings
EMA revealed significant CTE dose-dependent decreases in real-life affective valence (p = 0.007), energetic arousal (p = 0.032) and calmness (p = 0.044). Psychosocial questionnaires revealed a broad CTE-related psychosocial risk profile with dose-dependent increases in mental health risk-associated features (e.g., trait anxiety, maladaptive coping, loneliness, daily hassles; p values < 0.003) and a corresponding decrease in factors protective for mental health (e.g., life satisfaction, adaptive coping, optimism, social support; p values < 0.021). These results were not influenced by age, sex, socioeconomic status or education.

Conclusions
Healthy community-based adults with mild to moderate CTE exhibit dose-dependent changes in well-being manifesting in decreases in affective valence, calmness and energy in real life settings, as well as a range of established psychosocial risk features associated with mental health risk. This indicates an approach to early detection, early intervention, and prevention of CTE-associated psychiatric disorders in this at-risk population, using ecological momentary interventions (EMI) in real life, which enhance established protective factors for mental health, such as green space exposure, or social support.
Intramedullary spinal cavernous malformations with high ossification: a case report and review of the literature
Authors: Liu Weihao , Wang Chong , Wang Bo , Zhang Yaowu , Jia Wenqing 
Published: April 2023

Abstract
Background
Cavernous malformations of the spinal cord are a rare type of vascular malformation, comprising approximately 5 to 16% of all vascular lesions in the spinal cord. Depending on their origin position, these malformations can be distributed in different locations within the spinal canal. Although intramedullary cavernous malformations have been reported in the literature, they are exceedingly rare. Furthermore, highly calcified or ossified intramedullary cavernous spinal malformations are even rarer.

Case presentation
Here, we present a case report of a 28-year-old woman diagnosed with a thoracic intramedullary cavernous malformation. The patient had been experiencing progressive numbness in her distal limbs for a period of 2 months. During routine lung computed tomography screening for COVID-19, a hyperdense mass was noted in the patient’s spinal canal. Magnetic resonance imaging revealed a mulberry-shaped intramedullary mass at the T1-2 level. The patient underwent surgical treatment, during which the entire lesion was successfully removed, resulting in a gradual improvement of her symptoms. Histological examination confirmed the presence of cavernous malformations with calcification.

Conclusions
Intramedullary cavernous malformations with calcification are rare and special type that should be treated surgically in the early stage without significant neurological impairment before rebleeding or enlargement of the lesion can occur.
Polypharmacy and sustainable developmental goals: linking evidence-based medicine, patient engagement, and shared decision-making
Authors: Komatsu Yasuhiro 
Published: April 2023

AbstractSustainable Development Goals (SDGs) are an urgent call for action adopted by the United Nations to improve health and education, reduce inequality, and spur economic growth. The SDG 3 objective of good health and well-being is fundamentally linked to patient safety. Medication safety is a crucial issue in the promotion of health and well-being, and polypharmacy management is a key challenge in medication safety. Inappropriate polypharmacy can increase adverse drug events and health expenditures and reduce patient quality of life. As such, polypharmacy is prominent among older adults with chronic kidney disease. Optimal medication practice requires a high level of evidence-based medicine that integrates both scientific best evidence and patient values and preferences through a shared decision-making process. This article reviews polypharmacy management based on patient engagement and shared decision-making.
Screen time among school-aged children of aged 6–14: a systematic review
Authors: Qi Jingbo , Yan Yujie , Yin Hui 
Published: April 2023

Abstract
Background
Screen time refers to the time an individual spends using electronic or digital media devices such as televisions, smart phones, tablets or computers. The purpose of this study was to conduct systematic review to analyze the relevant studies on the length and use of screen time of school-aged children, in order to provide scientific basis for designing screen time interventions and perfecting the screen use guidelines for school-aged children.

Methods
Screen time related studies were searched on PubMed, EMBASE, Clinical Trials, Controlled Trials, The WHO International Clinical Trials Registry Platform, the Cochrane Central Register of Controlled Trials, CNKI, and Whipple Journal databases from January 1, 2016 to October 31, 2021. Two researchers independently screened the literature and extracted the data, and adopted a qualitative analysis method to evaluate the research status of the length and usage of screen time of school-aged students.

Results
Fifty-three articles were included. Sixteen articles studied screen time length in the form of continuous variables. Thirty-seven articles studied screen time in the form of grouped variables. The average screen time of schoolchildren aged 6 to 14 was 2.77 h per day, and 46.4% of them had an average screen time ≥ 2 h per day. A growth trend could be roughly seen by comparing studies in the same countries and regions before and after the COVID-19 outbreak. The average rates of school-aged children who had screen time within the range of ≥ 2 h per day, were 41.3% and 59.4% respectively before and after January 2020. The main types of screen time before January 2020 were watching TV (20 literatures), using computers (16 literature), using mobile phones/tablets (4 literatures). The mainly uses of screens before January 2020 were entertainment (15 literatures), learning (5 literatures) and socializing (3 literatures). The types and mainly uses of screen time after January 2020 remained the same as the results before January 2020.

Conclusions
Excessive screen time has become a common behavior among children and adolescents around the world. Intervention measures to control children's screen use should be explored in combination with different uses to reduce the proportion of non-essential uses.
Evaluation of Hem-o-lok clips in controlling the splenic pedicle in laparoscopic splenectomy in children
Authors: Eid Mahmoud Mohamed , Elshimy Khalid Mohammad , Elbatarny Akram Mohamed , Metwally Mohamed Fathy 
Published: April 2023

Abstract
Background
Splenectomy is an established therapeutic intervention for benign haematological disorders (BHD) in children. Laparoscopic splenectomy (LS) has become accepted as the preferred alternative to the open procedure. The aim of this study was to evaluate the Hem-o-lok clips in controlling the splenic hilum during laparoscopic splenectomy in children as regards feasibility, safety, operative time, cost, and perioperative complications.

Methods
This study included 27 cases with BHD, from April 2020 to December 2021, who underwent LS. In all patients, the Hem-o-lok clips were used to control the splenic pedicle. Operative time, intraoperative complications, need for conversion, and splenic extraction were reported. Postoperative course, complications, and hospital stay were also recorded. Patients were followed up for 3 months for development of complications and for evaluation of cosmetic appearance.

Results
The mean operative time, excluding splenic extraction, was 67.04 min. There were 3 intraoperative minor bleeding incidents, all not related to Hem-o-lok application, and they were successfully controlled, with no need for conversion. The mean hospital stay was 1.3 days. We used one cartridge for each case (cost; 686 LE, US $28).

Conclusions
The Hem-o-lok clips are feasible, safe, and cost effective in controlling the splenic hilum during LS in children with benign haematological diseases.
Chyle leak after transposition of the aberrant left vertebral artery via 1-debranching thoracic endovascular aortic repair: a case report
Authors: Nobuo Kondo , Hodaka Wakisaka , Yuta Kawashima , Kazuki Kihara , Takahiro Noda , Kensuke Oue 
Published: April 2023

Abstract
Background
Although the transposition of the aberrant left vertebral artery (ALVA) in 1-debranching thoracic endovascular aortic repair requiring zone 2 coverage for thoracic aneurysm with ALVA is reported to be an effective option, there are few reports of complications associated with the transposition of the ALVA.

Case presentation
An 87-year-old man underwent 1-debranching thoracic endovascular repair for a saccular thoracic aortic aneurysm with the aberrant left vertebral artery. Simultaneously, the transposition of the ALVA was performed to prevent cerebral complications because the left vertebral artery was dominant. Postoperative computed tomography revealed the reconstructed vertebral artery and no endoleak. However, a postoperative chyle leak occurred and was treated with lymphangiography.

Conclusion
Although the ALVA transposition is one of the better options, a chyle leak should be considered a serious complication of the procedure.
Management of Anxiety and Depression in Adult Survivors of Cancer: ASCO Guideline Update
Authors: Andersen Barbara L. , Lacchetti Christina , Ashing Kimlin , Berek Jonathan S. , Berman Barry S. , Bolte Sage , Dizon Don S. , Given Barbara , Nekhlyudov Larissa , Pirl William , Stanton Annette L. , Rowland Julia H. 
Published: April 2023

PURPOSETo update the American Society of Clinical Oncology guideline on the management of anxiety and depression in adult cancer survivors.METHODSA multidisciplinary expert panel convened to update the guideline. A systematic review of evidence published from 2013-2021 was conducted.RESULTSThe evidence base consisted of 17 systematic reviews ± meta analyses (nine for psychosocial interventions, four for physical exercise, three for mindfulness-based stress reduction [MBSR], and one for pharmacologic interventions), and an additional 44 randomized controlled trials. Psychological, educational, and psychosocial interventions led to improvements in depression and anxiety. Evidence for pharmacologic management of depression and anxiety in cancer survivors was inconsistent. The lack of inclusion of survivors from minoritized groups was noted and identified as an important consideration to provide high-quality care for ethnic minority populations.RECOMMENDATIONSIt is recommended to use a stepped-care model, that is, provide the most effective and least resource-intensive intervention based on symptom severity. All oncology patients should be offered education regarding depression and anxiety. For patients with moderate symptoms of depression, clinicians should offer cognitive behavior therapy (CBT), behavioral activation (BA), MBSR, structured physical activity, or empirically supported psychosocial interventions. For patients with moderate symptoms of anxiety, clinicians should offer CBT, BA, structured physical activity, acceptance and commitment therapy, or psychosocial interventions. For patients with severe symptoms of depression or anxiety, clinicians should offer cognitive therapy, BA, CBT, MBSR, or interpersonal therapy. Treating clinicians may offer a pharmacologic regimen for depression or anxiety for patients who do not have access to first-line treatment, prefer pharmacotherapy, have previously responded well to pharmacotherapy, or have not improved following first-line psychological or behavioral management. Additional information is available at www.asco.org/survivorship-guidelines .
ERβ in Granulosa Cell Tumors and Its Clinical Potential
Authors: Birgersson Madeleine , Indukuri Rajitha , Antonson Per , Nalvarte Ivan , Archer Amena , Williams Cecilia 
Published: April 2023

Abstract
Granulosa cell tumors (GCTs) are rare ovarian tumors comprising an adult and a juvenile subtype. They have a generally good prognosis, but the survival rate drastically declines in patients with late-stage or recurring tumors. Due to the rarity of GCTs, the tumor type is largely understudied and lacks a specific treatment strategy. Estrogen receptor beta (ERβ/ESR2) has been found to be highly expressed in GCTs, which could be of therapeutic importance since it can be targeted with small molecules. However, its role in GCTs is not known. In this review, we summarize the current knowledge about the action of ERβ in the ovary and discuss its prospective role in GCTs.
A Prediction-Based Approach for Online Dynamic Appointment Scheduling: A Case Study in Radiotherapy Treatment
Authors: Pham Tu San , Legrain Antoine , De Causmaecker Patrick , Rousseau Louis-Martin 
Published: April 2023

Patient scheduling is a difficult task involving stochastic factors, such as the unknown arrival times of patients. Similarly, the scheduling of radiotherapy for cancer treatments needs to handle patients with different urgency levels when allocating resources. High-priority patients may arrive at any time, and there must be resources available to accommodate them. A common solution is to reserve a flat percentage of treatment capacity for emergency patients. However, this solution can result in overdue treatments for urgent patients, a failure to fully exploit treatment capacity, and delayed treatments for low-priority patients. This problem is especially severe in large and crowded hospitals. In this paper, we propose a prediction-based approach for online dynamic radiotherapy scheduling that dynamically adapts the present scheduling decision based on each incoming patient and the current allocation of resources. Our approach is based on a regression model trained to recognize the links between patients’ arrival patterns and their ideal waiting time in optimal off-line solutions when all future arrivals are known in advance. When our prediction-based approach is compared with flat-reservation policies, it does a better job of preventing overdue treatments for emergency patients and also maintains comparable waiting times for the other patients. We also demonstrate how our proposed approach supports explainability and interpretability in scheduling decisions using Shapley additive explanation values. History: Accepted by Erwin Pesch, Area Editor for Heuristic Search & Approximation Algorithms. Funding: Mitacs Accélération IT26995 and Canada Research Chair in Analytics and Logistics in Healthcare (HANALOG). Supplemental Material: The software that supports the findings of this study is available within the paper and its Supplemental Information ( https://pubsonline.informs.org/doi/suppl/10.1287/ijoc.2023.1289 ) as well as from the IJOC GitHub software repository ( https://github.com/INFORMSJoC/2021.0342 ) at ( http://dx.doi.org/10.5281/zenodo.7579533 ).
Automation Enables Specialization: Field Evidence
Authors: Gong Jie , Png I. P. L. 
Published: April 2023

Becker and Murphy proposed that task specialization raises productivity but is limited by the costs of coordinating workers. We propose that automation enables workers to specialize without coordination costs. To the extent that the cost of effort exhibits increasing differences, workers increase effort in nonautomated tasks and productivity. The proposition is supported by a field experiment among supermarket cashiers. Conventionally, supermarket cashiers perform two tasks: scanning purchases and collecting payment. Cashiers exhibited increasing differences in the cost of effort: when they scanned faster, they took longer to collect payments. We rotated cashiers between the conventional job design and one in which they specialized in scanning. The new job design increased cashier productivity in scanning by more than 10%. The faster scanning was not due to customer sorting or cashier learning. The proposition is also validated by a survey of taxi drivers. Drivers who reported that difficulties in finding their way affected their driving were more likely to use map apps. This paper was accepted by Alfonso Gambardella, business strategy. Funding: This work was supported by the Singapore Ministry of Education [MOE2016-SSRTG-059]. Supplemental Material: The data files and online appendix are available at https://doi.org/10.1287/mnsc.2023.4760 .
The Interplay of Earnings, Ratings, and Penalties on Sharing Platforms: An Empirical Investigation
Authors: Xu Yuqian , Lu Baile , Ghose Anindya , Dai Hongyan , Zhou Weihua 
Published: April 2023

On-demand delivery through sharing platforms represents a rapidly expanding segment of the global workforce. The emergence of sharing platforms enables gig workers to choose when and where to work, allowing them to do so in a flexible manner. However, such flexibility brings notorious challenges to platforms in managing the gig workforce. Thus, understanding the incentive and behavioral issues of gig workers in this new business model is inherently meaningful. This paper investigates how the incentive mechanisms of sharing platforms—earnings, ratings, and penalties—affect the working decisions of gig workers and their nuanced relationships. To achieve this goal, we use data from one leading on-demand delivery platform with more than 50 million active consumers in China and implement a two-stage Heckman model with instrumental variables to estimate the impact of earnings, ratings, and penalties. We first show that better ratings motivate gig workers to work more. However, interestingly, when ratings are employed together with earnings, the two positive effects of ratings and earnings can be substitutes for each other. Second, we reveal that higher past penalties discourage workers from working more, whereas, interestingly, workers with higher past penalties tend to be more sensitive toward an increase in earnings. Finally, we conduct follow-up surveys to understand the underlying mechanisms of the observed moderating effects from both psychological and economic perspectives. The ultimate goal of this work is to provide managerial implications to help platform managers understand how earnings, ratings, and penalties work together to affect gig workers’ working decisions and how to manage high- and low-quality workers. This paper was accepted by David Simchi-Levi, entrepreneurship and innovation. Funding: This work was supported by the National Natural Science Foundation of China [Grants 72192823, 72172169, 71821002, 91646125, 72071206, 72231011, 72025405, and 72088101] and Program for Innovation Research at the Central University of Finance and Economics. Supplemental Material: The data files and online appendices are available at https://doi.org/10.1287/mnsc.2023.4761 .
Recruiting Talent Through Entrepreneurs’ Social Vision Communication
Authors: van Balen Timo , Tarakci Murat 
Published: April 2023

For-profit social ventures are proliferating. They often communicate social visions, presenting an ideal future where the ventures resolve environmental or societal issues. We study whether social vision communication helps a startup to recruit talent—a fundamental problem for growth. We argue that jobseekers are less likely to apply to ventures communicating a social vision as they perceive reduced career advancement opportunities. We conducted two complementary studies to test our theory. Study 1 enlisted data from a job board for startups to show that ventures communicating a social vision receive 46.3% fewer job applications. Study 2 replicated this finding in a field experiment that further reveals the underlying mechanism: social vision communication limits jobseekers’ perceived career advancement opportunities. Both studies show that higher remuneration can compensate the negative effect of social vision communication. Our findings advance research on purpose-driven organizations, human resources, entrepreneurship, and vision communication to caution entrepreneurs against social vision communication as a recruitment strategy. Supplemental Material: The online appendix is available at https://doi.org/10.1287/orsc.2023.1671 .
Living well with inflammatory bowel disease: a UK qualitative survey
Authors: Radford Shellie J , Sawyer Rachel 
Published: April 2023

Background: Chronic diseases, like inflammatory bowel disease (IBD), pose a significant health challenge in the UK. Addressing the needs of chronically ill patients is one of the important tasks for healthcare systems. To provide optimal support to patients with IBD, it is crucial to gain insight into their priorities. This requires a comprehensive understanding of what matters most to them. By identifying their needs and concerns, we can develop effective strategies to improve their care. Aim: This survey aimed to investigate opinions and personal experiences in relation to what people think are the most important factors when living with IBD and what it means to live well with the condition. Methods: People of any age or gender living with IBD were invited via social media (Twitter) to complete an anonymous online survey, created using Microsoft Forms and comprising three free-text questions to gather in-depth data. Results: From 45 responses, 42 reported symptom burden to be the most impactful aspect of living with IBD, impacting on work, education, social and leisure activities, as well as sex and intimacy. While 26 participants reported that living well with IBD meant to achieve complete symptom resolution, more participants spoke about having manageable symptoms without fluctuation. Achieving a normal level of daily activity was also important to participants. Conclusions: Most participants considered the most impactful aspect of IBD to be symptom management, alongside daily tasks such as work, education, social and leisure activities. They also felt that living well with IBD meant resolving or improving management of symptoms. Further exploration of the magnitude of symptom resolution that would be acceptable or preferable for people living with IBD is warranted.