bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Cyclooxygenase 2 Inhibitor Etoricoxib as Adjunctive Therapy in Tuberculosis Impairs Macrophage Control of Mycobacterial Growth
Authors: Nore Kristin G , Louet Claire , Bugge Marit , Gidon Alexandre , Jørgensen Marthe Jøntvedt , Jenum Synne , Dyrhol-Riise Anne Ma , Tonby Kristian , Flo Trude Helen 
Published: September 2023

Abstract

Background
Current tuberculosis treatment regimens could be improved by adjunct host-directed therapies (HDT) targeting host responses. We investigated the antimycobacterial capacity of macrophages from patients with tuberculosis in a phase 1/2 randomized clinical trial (TBCOX2) of the cyclooxygenase-2 inhibitor etoricoxib.

Methods
Peripheral blood mononuclear cells from 15 patients with tuberculosis treated with adjunctive COX-2i and 18 controls (standard therapy) were collected on day 56 after treatment initiation. The ex vivo capacity of macrophages to control mycobacterial infection was assessed by challenge with Mycobacterium avium, using an in vitro culture model. Macrophage inflammatory responses were analyzed by gene expression signatures, and concentrations of cytokines were analyzed in supernatants by multiplex.

Results
Macrophages from patients receiving adjunctive COX-2i treatment had higher M. avium loads than controls after 6 days, suggesting an impaired capacity to control mycobacterial infection compared to macrophages from the control group. Macrophages from the COX-2i group had lower gene expression of TNF, IL-1B, CCL4, CXCL9, and CXCL10 and lowered production of cytokines IFN-β and S100A8/A9 than controls.

Conclusions
Our data suggest potential unfavorable effects with impaired macrophage capacity to control mycobacterial growth in patients with tuberculosis receiving COX-2i treatment. Larger clinical trials are required to analyze the safety of COX-2i as HDT in patients with tuberculosis.

Clinical Trials Registration
NCT02503839.
Opening the Black Box of Transparency: An Analytical Framework for Exploring Causal Pathways from Reporting and Review to State Behavior Change
Authors: Harrould-Kolieb Ellycia , van Asselt Harro , Weikmans Romain , Vihma Antto 
Published: September 2023

AbstractTransparency arrangements, in the form of regular reporting by nations and a review of the reported information, have become a backbone of international governance. They are often expected to bring about increased ambition and improved implementation to fulfill the aims of the multilateral agreement in which they are embedded. However, little is still known about how these arrangements result in such effects. In this article, we review compliance theories and use these to explain the various roles of transparency arrangements in changing state behavior. We distinguish between different compliance schools and show how they attribute subtly different functions to transparency. We examine these variations through the development of a framework made up of seven idealized causal pathways that offer plausible explanations for the mechanisms that allow transparency arrangements to induce state behavior change. We also illustrate how these pathways work in practice by providing several examples from existing multilateral transparency arrangements. In doing so, we seek to form a bridge between international regime theory, critical transparency studies, and empirical studies on the functioning of transparency arrangements in international governance.
Standardized amino acid digestibility and nitrogen-corrected true metabolizable energy of frozen and freeze-dried raw dog foods using precision-fed cecectomized and conventional rooster assays
Authors: Oba Patrícia M , Utterback Pamela L , Parsons Carl M , Templeman James R , Swanson Kelly S 
Published: September 2023

Abstract
Commercial raw or minimally-processed diets, often referred to holistically as raw meat-based diets (RMBD) represent a small portion of the pet food market, but the growth of this sector has been significant in recent years. While traditionally, high-moisture, frozen options were the standard format of commercially available raw diets, freeze-dried raw diets have become more prevalent as of late. Despite the increasing popularity of these commercial raw diet formats, there is a dearth of literature describing their nutritional properties, particularly regarding freeze-dried diets. Therefore, the objective of this experiment was to determine and compare the standardized amino acid (AA) digestibilities and nitrogen-corrected true metabolizable energy (TMEn) of raw frozen and freeze-dried dog foods using precision-fed cecectomized and conventional rooster assays. Three formats of frozen or freeze-dried raw diets provided by Primal Pet Foods (Fairfield, CA, USA) were tested: traditional freeze-dried nuggets (T-FDN), hybrid freeze-dried nuggets (H-FDN), and frozen nuggets (FZN). Diets were fed to cecectomized roosters (4 roosters/diet) to determine AA digestibilities, while conventional roosters (4 roosters/diet) were used to determine TMEn. In both cases, after 26 h of feed withdrawal, roosters were tube-fed 12 to 13 g of test diets and 12 to 13 g of corn. Following crop intubation, excreta were collected for 48 h. Endogenous corrections for AA were made using five additional cecectomized roosters. All data were analyzed using the Mixed Models procedure of SAS version 9.4. There were no significant differences in standardized AA digestibilities among diets, with digestibilities being high for all diets tested. For most of the indispensable AA, digestibilities were greater than or equal to 90% for all diets. Histidine and lysine were the exceptions, with digestibilities ranging from 82% to 87% and 87% to 92%, respectively. Moreover, the reactive lysine:total lysine ratio, a measure of heat damage, ranged from 0.91 to 0.95. TMEn values were higher (P = 0.0127) in T-FDN (6.1 kcal/g) and FZN (5.9 kcal/g) than H-FDN (5.3 kcal/g) and were most similar to those estimated by Atwater factors. In general, all diets tested had high AA digestibilities and had TMEn values that were most similar to Atwater factors.
Native natural enemies of plant pests in Slovenia with an emphasis on species suitable for mass rearing
Authors: Trdan Stanislav , Laznik Žiga , Bohinc Tanja 
Published: September 2023

Abstract
In Slovenia, only the native natural enemies of plant pests that are on the EPPO Positive List of biological control agents can be used in agricultural production to control plant pests. The List of native species of organisms for biological control, which is an important part of the Regulations on biological control, currently includes a total of 35 species of beneficial insects and mites and entomopathogenic nematodes. Compared to the number of species on the first list that was established in 2006, the number of beneficial species that Slovenian growers of food and ornamental plants can currently use in everyday practice has doubled. This is the result of intensive professional and research work in the investigation of the occurrence and distribution of natural enemy species in Slovenia, which has been systematically supported by the state for many years. Natural enemy species, which are an integral part of the EPPO Positive List of biological control agents, can be included on the list of native biological control species via a special procedure. However, many natural enemy species that are not yet included on the EPPO Positive List have been identified in the period 2007–2022. In this paper, we list 75 such species and we present 5 candidates (Cotesia glomerata [L.], Diadegma semiclausum [Hellen], Anisopteromalus calandrae [Howard], Neochrysocharis formosa [Westwood] and Kampimodromus aberrans [Oudemans]) that, in our opinion, have high potential as biological controls and will be suitable in the future for mass rearing and use in augmentative biological control.
Biological basis for adoption of an isoline of Telenomus remus (Hymenoptera: Scelionidae) for an augmentative biological-control program for Spodoptera frugiperda (Lepidoptera: Noctuidae)
Authors: de Lacerda Lucas Fonseca , Coelho Aloisio , de Paula Pedro Holtz , Amorim Deoclécio J , Demetrio Clarice G B , Parra José Roberto Postali 
Published: September 2023

Abstract
The widely distributed, polyphagous fall armyworm, Spodoptera frugiperda (J.E. Smith, 1797), is one of the most important crop pests worldwide. The egg-parasitoid wasp, Telenomus remus Nixon, 1937, is frequently described as a possible control agent for S. frugiperda. We selected an isoline of T. remus and evaluated its parasitism potential (for 24 h) in S. frugiperda eggs, in laboratory conditions, and also its ability to fly at different temperatures and relative humidity levels, aiming to provide basic information about this isoline. The selected isoline maintained good flight capacity without affecting its parasitism efficiency or developing inefficient haplotypes for biological-control programs, compared across generations to a regularline laboratory-reared for more than 60 generations. The flight capacity of the isoline was best at 25–30 °C and relative humidity 70–90%.
Reproductive performance effects of rearing the quasi-social parasitoid,Sclerodermus brevicornis(Hymenoptera: Bethylidae), on a factitious host
Authors: Malabusini Serena , Hardy Ian C W , Jucker Costanza , Guanzani Greta , Savoldelli Sara , Lupi Daniela 
Published: September 2023

AbstractWasps in the genus Sclerodermus are ectoparasitoids that typically attack the larvae of woodboring coleopterans. Interest in these species is increasing as they are used in programs to control longhorn beetle pests of economic importance in China and have invasive pest control potential in Europe. Wasps may be mass reared for field release, but using the target host species can be time consuming and physically demanding. There is thus a need for factitious hosts with lower production costs and that are easier to rear. The present research focuses on Sclerodermus brevicornis, which was found in Italy in association with the invasive longhorn beetle, Psacothea hilaris hilaris, and can be laboratory reared on this longhorn beetle and on a factitious lepidopteran host, Corcyra cephalonica. As it is known that the biology of natural enemies can be influenced by the host they emerge from and that the behavior of S. brevicornis is relatively complex due to its degree of sociality (multiple foundress females cooperate to paralyze the host and produce offspring communally), we explored whether, and how, performance and behavioral traits of adult females are influenced by the host species on which they were reared, both when no choice or a choice of current host species was offered. We evaluated the survival of foundresses and their movements between offered hosts and their tendency to form groups with other foundresses according to kinship and host characteristics. We also evaluated the production of offspring and the timing of their development. We found that S. brevicornis reared from C. cephalonica do have some disadvantages compared with those that have developed on P. h. hilaris but also that they recognize, prefer, and can reproduce on P. h. hilaris. We conclude that the use of the more convenient factitious host for mass-rearing is unlikely to greatly compromise the potential of S. brevicornis to suppress longhorn beetle pests in the field.
Quality control applications for recovering an inbred colony of Bagrada hilaris (Hemiptera: Pentatomidae)
Authors: Ivey Cleveland B , Leppla Norman C , Hodges Amanda C , Eger Joe E 
Published: September 2023

Abstract
The invasive stink bug, Bagrada hilaris (Burmeister), recently became established in the southwestern United States and has become a major pest of broccoli and other cole crops. Due to concerns about its possible establishment in Florida, a colony of this pest was maintained in quarantine to conduct research on its environmental requirements. The colony was reared reliably with approximately 300 adults per generation but began to decline in generation 16. Due to unknown causes, only about 73 females were recovered to mate and oviposit during the final 46 days. However, a corresponding decrease in the number of mated pairs did not reduce the yield of eggs, nymphs, and adults per day, but the females were maintained for fewer than the normal 160 days per generation. Therefore, quality control procedures were implemented to increase the number of days the colony produced adults in subsequent generations. The goal of producing approximately 400 adults per generation was accomplished during 104, 160, and 156 days, respectively, in generations 17, 18, and 19. The purpose of this research was to develop quality control procedures for rearing B. hilaris, use the procedures to restore a colony in quarantine, and describe how quality control can be used to maintain small colonies of insects. Implementing quality control procedures when a colony is established can help to prevent its decline.
Efficacy and safety of olaparib, olaparib plus bevacizumab and niraparib maintenance treatment in Japanese patients with platinum-sensitive advanced ovarian cancer
Authors: Nakamura Keiichiro , Matsuoka Hirofumi , Yorimitsu Masae , Ogawa Mariko , Kanemori Miho , Sueoka Kotaro , Kozai Ayumi , Nakamura Hiroko , Haruma Tomoko , Shiroyama Yuko , Hayata Yuu , Sugii Hirokazu , Ueda Akiko , Kurihara Shuichi , Urayama Saiko , Shimizu Miyuki , Masuyama Hisashi 
Published: September 2023

Abstract

Objective
To investigate whether maintenance treatment could be safely and effectively performed with olaparib, olaparib plus bevacizumab and niraparib in platinum-sensitive advanced ovarian cancer at multiple institutions in Japan.

Methods
We investigated progression-free survival and adverse events in 117 patients with platinum-sensitive advanced ovarian cancer treated with maintenance therapy.

Results
The median progression-free survival of 117 patients was 20.1 months. Patients with germline BRCA pathogenic variants had a significantly better prognosis than the other groups (P &lt; 0.001). Furthermore, in the multivariate analysis, stage IV (P = 0.016) and germline BRCA wild-type (P ≤ 0.001) were significantly associated with worse progression-free survival in patients with advanced ovarian cancer. Regarding adverse events, all three types of maintenance treatment were significantly worse than chemotherapy given before maintenance treatment with respect to renal function (olaparib, P = 0.037; olaparib plus bevacizumab, P &lt; 0.001; and niraparib, P = 0.016).

Conclusion
Maintenance treatment was performed effectively and safely. Renal function deterioration is likely to occur during maintenance treatment, and careful administration is important in platinum-sensitive advanced ovarian cancer.
Vertebral fracture at the caudal end of diffuse idiopathic skeletal hyperostosis treated with vertebroplasty via double-endplate penetrating screw trajectory and posterior spinal fixation with a new hybrid strategy using cement-augmented fenestrated pedicle screws
Authors: Hashiba Daisuke , Fujimoto Kazuki , Nakagawa Ryosuke , Maeyama Toshifumi , Arai Hajime , Ohtori Seiji 
Published: September 2023

Abstract
Vertebral fractures in diffuse idiopathic skeletal hyperostosis (DISH) are often unstable. We encountered a case of vertebral fracture at the caudal end of DISH in which vertebroplasty was performed via a double endplate penetrating screw (DEPS) trajectory, and short posterior fixation was performed using the DEPS technique on the cranial vertebrae, including the fractured vertebra; conventional pedicle screw to the caudal vertebrae; and cement-augmented fenestrated pedicle screws to the caudal end vertebra. A 93-year-old man presented with a vertebral fracture at the caudal end of a DISH after a fall. He underwent surgery for lower back pain due to spinal instability. Vertebroplasty via DEPS trajectory can shorten the posterior fixation range. Using cement-augmented fenestrated pedicle screws to the caudal end vertebra enables balancing of the posterior fixation force. This strategy should be considered when a vertebral fracture is found at the caudal end of the DISH.
Toothpick perforates small bowel-mimicking diverticulitis
Authors: Fallatah Ahmed A , Mashbari Hassan , Daghestani Hatoon , Mostafa Omar , Alshahwan Nawaf , Alburakan Ahmed , Nouh Thamer 
Published: September 2023

Abstract
Bowel perforation is an emergency condition that requires critical thinking and readily intervention; nevertheless, on occasions, its presentation can be challenging to diagnose. Several etiologies could cause bowel perforation, including obstruction, mass, inflammation, ischemia, etc. On rare occasions, a foreign body could be the cause of perforation, which mandates a detailed history and focused review of the images when the patient’s condition allows. We report a case of ileal perforation caused by an ingested wooden toothpick that was suspected on the CT images, which the patient has no memory of ingesting.
The SALT OVERLY SENSITIVE 2–CONSTITUTIVE TRIPLE RESPONSE1 module coordinates plant growth and salt tolerance in Arabidopsis
Authors: Li Qinpei , Fu Haiqi , Yu Xiang , Wen Xing , Guo Hongwei , Guo Yan , Li Jingrui 
Published: September 2023

Abstract
High salinity stress promotes plant ethylene biosynthesis and triggers the ethylene signalling response. However, the precise mechanism underlying how plants transduce ethylene signalling in response to salt stress remains largely unknown. In this study, we discovered that SALT OVERLY SENSITIVE 2 (SOS2) inhibits the kinase activity of CONSTITUTIVE TRIPLE RESPONSE1 (CTR1) by phosphorylating the 87th serine (S87). This phosphorylation event activates the ethylene signalling response, leading to enhanced plant salt resistance. Furthermore, through genetic analysis, we determined that the loss of CTR1 or the gain of SOS2-mediated CTR1 phosphorylation both contribute to improved plant salt tolerance. Additionally, in the sos2 mutant, we observed compromised proteolytic processing of ETHYLENE INSENSITIVE 2 (EIN2) and reduced nuclear localization of EIN2 C-terminal fragments (EIN2-C), which correlate with decreased accumulation of ETHYLENE INSENSITIVE 3 (EIN3). Collectively, our findings unveil the role of the SOS2–CTR1 regulatory module in promoting the activation of the ethylene signalling pathway and enhancing plant salt tolerance.
Bringing home the carbon: photorespiratory CO2 recovery shows diverse efficiency inBrassicaceae
Authors: Walsh Catherine A 
Published: September 2023

This article comments on:Schlüter U, Bouvier JW, Guerreiro R, Malisic M, Kontny C, Westhoff P, Stich B, Weber APM. 2023. Brassicaceae display variation in efficiency of photorespiratory carbon-recapturing mechanisms. Journal of Experimental Botany 74, 6631–6649.
Disseminated Mycobacterium abscessus infection with osteoarticular manifestations as an important differential diagnosis of inflammatory arthritis: A case report and literature review
Authors: Watanabe Chihaya , Yoshida Yusuke , Kidoguchi Genki , Kitagawa Hiroki , Shoji Takeshi , Nakamoto Naoki , Oka Naoya , Sugimoto Tomohiro , Mokuda Sho , Hirata Shintaro 
Published: September 2023

ABSTRACT
This case report describes a 52-year-old immunocompromised man diagnosed with disseminated Mycobacterium abscessus complex (MABC) infection. The patient had a history of malignant lymphoma and presented with fever and polyarthritis that lasted 3 weeks. Upon initial evaluation, blood and synovial fluid cultures from the swollen joints were negative. Reactive arthritis or rheumatoid arthritis was suspected as the cause of inflammatory synovitis in multiple joints. Administration of prednisolone followed by an interleukin-6 inhibitor improved the fever, but polyarthritis persisted, and destruction of the left hip joint was observed. Two months later, M. abscessus was detected in a blood culture and right shoulder joint synovium, leading to a final diagnosis of disseminated MABC infection. The joint symptoms resolved with combined antimicrobial therapy using amikacin, azithromycin, and imipenem/cilastatin. To date, 12 cases of disseminated MABC infection with osteoarticular manifestations have been reported. A total of 13 cases, including the present case, were reviewed. Seven patients had bone involvements, five had joint involvement, and the remaining one had bursa involvement. All the cases with joint involvement, except for our case, presented with monoarthritis. MABC infection is diagnosed based on the demonstration of MABC itself. Clinicians should keep disseminated MABC infection in mind as a possible cause of persistent arthritis. As demonstrated in our case, multiple replicate cultures of blood or specimens from the affected sites may be needed to detect it.
Dissecting the contributions of organic nitrogen aerosols to global atmospheric nitrogen deposition and implications for ecosystems
Authors: Li Yumin , Fu Tzung-May , Yu Jian Zhen , Yu Xu , Chen Qi , Miao Ruqian , Zhou Yang , Zhang Aoxing , Ye Jianhuai , Yang Xin , Tao Shu , Liu Hongbin , Yao Weiqi 
Published: September 2023

ABSTRACT
Atmospheric deposition of particulate organic nitrogen (ONp) is a significant process in the global nitrogen cycle and may be pivotally important for N-limited ecosystems. However, past models largely overlooked the spatial and chemical inhomogeneity of atmospheric ONp and were thus deficient in assessing global ONp impacts. We constructed a comprehensive global model of atmospheric gaseous and particulate organic nitrogen (ON), including the latest knowledge on emissions and secondary formations. Using this model, we simulated global atmospheric ONp abundances consistent with observations. Our estimated global atmospheric ON deposition was 26 Tg N yr−1, predominantly in the form of ONp (23 Tg N yr−1) and mostly from wildfires (37%), oceans (22%) and aqueous productions (17%). Globally, ONp contributed as much as 40% to 80% of the total N deposition downwind of biomass-burning regions. Atmospheric ONp deposition thus constituted the dominant external N supply to the N-limited boreal forests, tundras and the Arctic Ocean, and its importance may be amplified in a future warming climate.