bluuebunny/crossref_metadata_2025_split huggingface dataset:
The relationship between first-dose antibiotic delay intervals and in-hospital mortality on patients with sepsis
Authors: Zhang Chenhong , Huang Hao , Bai Zhaoqing 
Published: August 2023

Abstract
Background To investigate the association between the time interval of antibiotic use and patient in-hospital mortality on sepsis patients, we quantified the time interval of first antibiotic administration in sepsis patients, namely diagnosis delay and administration delay, and explored the relationship between these delay times and patient prognosis.Methods A retrospective study of 452 patients with sepsis attending the emergency department from January 2020 to December 2022 was conducted to quantify the time interval of first antibiotic use, and use the Logistic analysis to evaluatethe the affect on prognosis and antibiotic use interval in these patients.Results Both delay in diagnosis and delay in administration of antibiotics were associated with in-hospital mortality, but there was no significant difference in diagnostic delay for less than 6 hours or administration delay for less than 3 hours when compared with the paired control group without delay.Conclusions Antibiotic delay in sepsis is associated with patient outcomes, but only for longer delays.There was no significant difference in in-hospital mortality between antibiotics use within 1 hour and 3 hours.
Association of Angiogenesis-Related Gene Mutations with Tumor Microenvironment and their Clinical Significance in Bladder Cancer
Authors: Guo Xiaoxiao , Cao Rui , Hao Gangyue 
Published: August 2023

Abstract
Background: Immunotherapy has emerged as a crucial treatment option for various types of cancer, including bladder cancer (BC). The effectiveness of immunotherapy depends on the intricate interplay between the tumor microenvironment (TME) and cancer cells. Angiogenesis, a key feature of cancer progression, has not been fully understood in relation to clinical outcomes, immune cell infiltration, and the impact on immunotherapy in BC.
Methods: We systematically evaluated the expression patterns of genes in 10 predefined angiogenesis-related gene (ARG) sets using data from TCGA and GEO cohorts, and subsequently investigated the association between angiogenesis and transcriptional profiles, as well as their impact on prognosis and immune cell infiltration. An ARG_Score was developed to quantify the angiogenesis subtypes of individual patients, and its potential for predicting prognosis and therapeutic response in BC was assessed.
Results: ARG mutations were identified to be associated with the clinicopathological characteristics, prognosis, and infiltrating TME of patients. The established ARG_Score was significantly associated with the tumor microenvironment and clinical outcomes. A lower ARG_Score was characterized by elevated immune activation and better overall survival (OS). Moreover, the ARG_Score was markedly correlated with drug susceptibility. A nomogram based on the ARG_Score was shown to have high reliability in predicting the OS of BC.
Conclusion: ARG mutations affect the TME, clinicopathological features and prognosis of BC. Utilizing ARG_Score enables the prediction of patients' response to immunotherapy or chemotherapy and improves the accuracy of prognosis prediction.
Spatial analysis of urban sprawling with an emphasis on ecological infrastructure integrity (Case study: Miandoab City)
Authors: Alemohammad Sayedeh , Nasehi Saeedeh , Alemohammad Ali Asghar , Mehrian Majid Ramezani , Farhadi Reza 
Published: August 2023

Abstract
The sprawling growth of urban settlements is a dominant spatial process in many cities of developing countries. This development's most severe apparent effects are the loss of ecological infrastructure. In this way, consequently, the ecosystem services that have been provided for human settlements for thousands of years will be lost. This research aims to spatially analyze the sprawling growth of Miandoab City with an emphasis on ecological infrastructures. In this regard, first, land cover maps have been prepared. Then the future land cover is simulated and predicted by the CA-MARKOV chain method. Also, the metrics of the number of patches, the patch size, and the patch cohesion of spots have been calculated for all land cover types in the landscape. In addition, the urban expansion intensity in different directions and changes in the density of built land cover have been estimated. According to the findings, Miandoab City has experienced a very sprawling growth until 2023, during which the structural integrity of green infrastructure and bare lands has been severely destroyed in favor of built land cover. The direction of physical-spatial development of the city has been towards the eastern suburbs. Most of the bare lands and intensive growth potential are in these areas. Solutions with three strategies (protective, defensive, and opportunistic) have been presented for balancing physical-spatial development and increasing urban and extra-urban ecological infrastructure integrity.
Facile metabolic reprogramming distinguishes mycobacterial adaptation to hypoxia and starvation:
The role of ketosis in starvation-induced persistence
Authors: Dedon Peter , Davis Nick , Chionh Yok Hian , McBee Megan , Hia Fabian , Ma Duanduan , Liang Cui , Sharaf Mariam , Cai Weiling Maggie , Jumpathong Watthanachai , Levine Stuart , Alonso Sylvie 
Published: August 2023

Abstract
Mycobacteria adapt to infection stresses by entering a reversible non-replicating persistence (NRP) with slow or no cell growth and broad antimicrobial tolerance. Hypoxia and nutrient deprivation are two well-studied stresses commonly used to model the NRP, yet little is known about the molecular differences in mycobacterial adaptation to these distinct stresses that lead to a comparable NRP phenotype. Here we performed a multisystem interrogation of the Mycobacterium bovis BCG (BCG) starvation response, which revealed a coordinated metabolic shift away from the glycolysis of nutrient-replete growth to depletion of lipid stores, lipolysis, and fatty acid ß-oxidation in NRP. This contrasts with BCG’s NRP hypoxia response involving a shift to cholesterol metabolism and triglyceride storage. Our analysis reveals cryptic metabolic vulnerabilities of the starvation-induced NRP state, such as their newfound hypersensitivity to H2O2. These observations pave the way for developing precision therapeutics against these otherwise drug refractory pathogens.
Research on Unbalanced Sample Classification Algorithm Based on Redundant Data Elimination
Authors: YU TINGTING , SUN YU 
Published: August 2023

Abstract
The unlabeled data in multi-user social network is unbalanced, which leads to poor classification in the process of data scheduling and detection. In order to reduce the error rate of unlabeled unbalanced sample data classification in multi-user social network, a method of unlabeled unbalanced sample data classification in multi-user social network based on redundant data elimination is proposed. The subspace fusion filter detection model is used to filter redundant data and suppress anti-interference on the prior features of randomly sampled unlabeled unbalanced sample data of multi-user social network, the statistical average analysis and distributed fusion detection method of autocorrelation features are used to extract the clustering convergence feature parameters of unlabeled unbalanced sample data of multi-user social network, and the constrained evolution method of multi-level iterative regression analysis is used to estimate the classification feature quantity of unlabeled unbalanced sample data. The characteristic parameters of the classification target are input into the SVM classifier, and the adaptive weight distribution control of SVM classification is carried out in combination with the dynamic learning algorithm, which improves the adaptability of data classification and realizes the optimal classification of unlabeled unbalanced sample data in multi-user social networks. The simulation results show that this algorithm can effectively reduce the interference of redundant data when classifying unlabeled unbalanced sample data of multi-user social network, and the fidelity rate of data classification is high, and the error rate is low, which improves the dynamic data management ability of multi-user social network.
Analysis of high temperature trends and spatial and temporal distribution characteristics in Inner Mongolia in the last fifty years
Authors: Wang Shaohui , Zhou Chunjiang , Li Hui , Huang Gang , Liu Dongwei 
Published: August 2023

Abstract
Using the daily maximum temperature and ECMWF Reanalysis v5 (ERA5) reanalysis data of 11 municipal meteorological stations in Inner Mongolia in summer, the comfort index (33.5°C), a high temperature threshold for the Inner Mongolia Region, was redefined by the percentile method and the Climatology method. The weather with maximum temperature ≥ 33.5°C was statistically analyzed and the spatial and temporal distribution of extreme high temperature in Inner Mongolia during the summer of 1973–2022 was studied. The results show that the average temperature in Inner Mongolia has increased in the past 50 years; the total number of high temperature days in the 23 years studied was 1179, with the highest number of high temperature days in Alashan League (265) and the lowest number of high temperature days in Hulunbeier City (18); The total number of hot days in Inner Mongolia from low to high is in the middle, east and west. The findings of the study can provide reference for the research on high temperature and agriculture and health in Inner Mongolia Region.
Pancreas-sparing tumor resection for peripancreatic paraganglioma: A case series of six patients
Authors: Sunakawa Taiki , Kobayashi Shin , Kudo Masashi , Sugimoto Motokazu , Kobayashi Tatsushi , Gotohda Naoto 
Published: August 2023

Abstract
Background Paragangliomas(PGLs) located around the pancreas are rare and challenging to diagnose preoperatively. Tumor resection with pancreatectomy is often performed for peripancreatic PGL. However, pancreas-sparing tumor resection can be indicated with an accurate preoperative diagnosis.Methods This case series included six patients with pathologically diagnosed peripancreatic PGL resected at the National Cancer Center Hospital East between 2002 and 2020. The clinical data of the patients were retrospectively collected from our medical records.Results Five of six patients were suspected of peripancreatic PGL on imaging studies due to the fat plane identified between the hypervascular tumor and pancreas, and subsequently diagnosed with PGL preoperatively based on elevated urinary catecholamine levels and/or metaiodobenzylguanidine scintigraphy results without tumor biopsy. All patients underwent pancreas-sparing tumor resection with negative surgical margins, and they did not develop postoperative complications related to potential damage to the pancreas.Conclusions A fat plane between the hypervascular tumor and pancreas on imaging studies and hormone levels are key findings for obtaining an accurate preoperative diagnosis of peripancreatic PGL, which can be managed with pancreas-sparing tumor resection.
Growth of fungi and yeasts in food production waste streams: a bioremediation feasibility study
Authors: Bansfield Danielle , Spilling Kristian , Mikola Anna , Piiparinen Jonna 
Published: August 2023

Abstract
Food production produces large amounts of nutrient-rich waste streams which are disposed of - a wasted opportunity given nutrients such as phosphorus and nitrogen are in short supply. A more circular approach would be to reuse these waste streams. Fungi and yeasts are possible candidates as they require lots of organic carbon (which is especially high in food production waste streams) for growth, producing value-added biomass. Here, we determined the growth of seven fungi and three yeasts in five different food production waste streams. Initial tests were done to find the most appropriate waste stream for growth. All species were then cultured in the waste stream best suited for growth. Oxygen uptake was measured to gauge metabolic activity and as a proxy for growth rate. Pelletization’s effect on metabolic rates was tested on the most pellet-forming species, by adding agar to inhibit pellet formation. The most promising waste stream for yeast/fungal growth was cheese whey (Whey). Pellet inhibition (i.e., filamentous growth) resulted in increased metabolism in the confectionary bakery waste stream but decreased metabolism in Whey. The best growing species, Geotrichum candidum, has potential commercial value as a producer of enzymes, biochemicals and lipids and could provide added value while improving the circularity of water and nutrients in food production.
Optimal Allocation of DSTATCOM to Improve Operational Performance of Microgrid Network with Plug-in Electrical Vehicle Charging Station
Authors: Yasmeena . , Lakshmi Shubh , Tewari Somesh Vinayak 
Published: August 2023

Abstract
Microgrids (MGs) are getting installed with plug-in electric vehicle charging stations (PEVCSs) to provide charging services to plug-in electric vehicles. However, the integration of PEVCSs greatly affects the operational performance of MGs. This paper presents optimization- and exhaustive search-based approaches for optimal allocation of DSTATCOM to improve the operational performance of an existing MG with PEVCS. A two-stage optimization problem is formulated. In stage 1 optimization, the total cost of MG planning which includes installation costs, operation and maintenance costs, generation costs, emission costs, and cost of energy loss, is minimized to optimally allocate generating units. In stage 2 optimization, the operational performance index of MG which is a weighted sum of the voltage deviation index and energy loss index is minimized to optimally allocate PEVCS and DSTATCOM. Further, exhaustive search-based approaches are developed to know the impact of the placement of a PEVCS in different locations of MG and to know whether the placement of DSTATCOM in the same location of PEVCS or in a different location is better for improving the operational performance of MG with PEVCS. The standard 33-bus network is used to validate the approaches. The simulation results show that the optimal placement of DSTATCOM significantly improves the operational performance of MG with PEVCS.
Comparative putative metabolites profiling of Tachypleus gigas and Carcinoscorpius rotundicauda hemocytes stimulated with lipopolysaccharide
Authors: jasni Nurhana , Wee Chee Lee , Ismail Noraznawati , Yaacob Nik Soriani , Othman Nurulhasanah 
Published: August 2023

Abstract
Horseshoe crabs are among the most studied invertebrates due to their unique, innate immune system and biological processes. The metabolomics study was conducted on lipopolysaccharide (LPS)-stimulated and non-stimulated hemocytes isolated from the Malaysian Tachypleus gigas and Carcinoscorpius rotundicauda. LC-TOF-MS, multivariate analyses, Principal Component Analysis (PCA), and Partial least squares-discriminant analysis (PLS-DA) were included in this study to profile the metabolites. A total of 37 metabolites were identified to be differentially abundant and were selected based on VIP>1. However, of the 37 putative metabolites, only 23 were found to be significant with ANOVA at p< 0.05. The metabolites were identified using several databases, and the literature review of the metabolites was reported in the manuscript. Thus, this study has provided further insights into the putative metabolites' presence in the hemocytes of horseshoe crabs that are stimulated and non-stimulated with LPS and their abundance in each species. Several putative metabolites showed they have medicinal values from previous studies.
Does vaginal bacterial colonization contribute to preterm birth in women with asymptomatic shortened cervix?
Authors: Steetskamp Joscha , Zander Mara , Laufs Valeria , Elger Tania , Hasenburg Annette , Skala Christine Elisabeth 
Published: August 2023

Abstract
Purpose
The aim of this study is to describe the typical microbial spectrum and the influence of distinct vaginal infections on preterm birth in pregnancies affected by cervical incompetence.
Methods
327 patients were admitted because of asymptomatic shortening of the cervix in the second and third trimester of pregnancy. Clinical data like age, cervical length, gestational age at admission and at delivery and vaginal microbiologic findings were collected and analyzed.
Results
The spectrum of germs in the vagina revealed seven different distinct species, the most common bacteria were Ureaplasma spp. and E. coli. In 327 included patients, 217 revealed a bacterial colonization, 110 did not. Most common bacteria in women with preterm birth before 34 weeks were Ureaplasma spp., while E. coli was most common in women undergoing preterm birth after 34 weeks. Nevertheless, the rates of occurrence of these bacterial taxa were not significantly different between who underwent preterm birth to those who did not
Conclusions
This study gives an overview over the vaginal bacterial colonization in pregnant women with cervical incompetence. The clinical relevance of vaginal bacterial colonization remains unclear.
Tunneling nanotubes (TNT) between free living amoebae: a new route for microbial resistance and pathogenesis?
Authors: costa damien , Lefebvre Marion , Benard Magalie , Razakandrainibe Romy , Villena Isabelle , Favennec Loic , Galas Ludovic 
Published: August 2023

Abstract
Free-living amoebae (FLA) have multiple roles in the ecology of microorganisms. Tunneling nanotubes (TNTs) are cytoplasmic bridges now considered as a major pathway of cell-to-cell communication for eukaryotic mammalian cells. Interestingly, TNTs can be hijacked by microorganisms to promote their intercellular spreading. Here, type 1 and type 2 of TNTs were observed between trophozoites of Acanthamoeba castellanii. Both types of TNTs contained actin while tubulin was only detected in TNT1. Hovering freely above substratum, TNT1 connected isolated long distance motile amoebae with a length up to 82 µm. In contrast, TNT2 (< 5µm) bridged short distance between FLA trophozoites. The mechanism of TNT formation in amoebae is likely to be through cell dislodgement. To our knowledge, this is the first time that TNTs were observed between unicellular eukaryotes. It suggest a primitive mode of cell connectivity and upset current knowledge. This opens many study opportunities including microbial exchange and resistance.
Multi Agent Collaborative Search Many-objective Optimization Algorithm
Authors: Cao Li , Wang Maocai , Dai Guangming , Vasile Massimiliano 
Published: August 2023

Abstract
MACS (Multi Agent Collaborative Search) is a creative multi-objective optimization algorithm which is effective for handling standard benchmarks and real engineering problems. It has a long improving history and the latest version is Improved archiving and search strategies for Multi Agent Collaborative Search (MACS2.1). But its ability on solving many-objective optimization problems is not good enough. This paper extends the original MACS2.1 to improve its performance to treat those problems and proposes a new multi agent collaborative search many-objective optimization algorithm (named Ma-MACS). Firstly, a more reasonable computing resources allocation approach (utility function) is applied to balance the quality for each individual. Secondly, a neighborhood updating process is embedded to increase evolution speed. Next, more mutation operators and related choosing strategy are applied to enhance the quality of the offspring. Finally, a weight vectors adjusting procedure is introduced to replace the inappropriate vectors. The new algorithm is compared with some state-of-art algorithms and MACS2.1 on the test cases.
Different effects of social intention on movement kinematics when interacting with a human or virtual agent
Authors: Gigliotti Maria Francesca , Desrosiers Paul-Audain , Ott Laurent , Daoudi Mohamed , Coello Yann 
Published: August 2023

Abstract

The execution of object-directed motor actions is known to be influenced by the intention to interact with others. In this study, we tested whether the effects of social intention on the kinematics of object-directed actions depended on whether the task was performed in the presence of a human or a virtual confederate. In two experiments, participants had to grasp a glass and place it to a new position, with either a personal intention (to fill the glass themselves using a bottle) or a social one (to have the glass filled by the human confederate or the virtual agent using the bottle). Experiment 1 showed that the kinematics of the object-directed actions was modulated by the social intention but only when interacting with a human confederate. Experiment 2 showed that the effects of social intention on object-directed actions performance can be improved using feedback-based learning. Specifically, participants proved able to progressively adapt their motor performances to express social intention to a virtual confederate as well. These findings emphasize the importance of the modulatory role of social intention on non-verbal motor behaviour, and enrich the understanding of the interaction with virtual agents.
Characteristics of incidental prostate cancer in the United States
Authors: Scheipner Lukas , Incesu Reha-Baris , Morra Simone , Baudo Andrea , Assad Anis , Jannello Letizia , Siech Carolin , de Angelis Mario , Barletta Francesco , Tian Zhe , Saad Fred , Shariat Shahrokh F. , Briganti Alberto , Chun Felix , Tilki Derya , Longo Nicola , Carmignani Luca , De Cobelli Ottavio , Ahyai Sascha , Karakiewicz Pierre 
Published: August 2023

Abstract
Background: Data regarding North-American incidental (cT1a/b) prostate cancer (PCa) patients is scarce. To address this, incidental PCa characteristics (age, PSA values at diagnosis, Gleason score [GS]), subsequent treatment and cancer-specific mortality rates were explored.Methods: Incidental PCa patients were identified within the Surveillance, Epidemiology, and End Results (SEER) database (2004–2015). Descriptive statistics, annual percentage changes (EAPC), Kaplan-Meier plots, as well as Cox regression models were used.Results: Of all 344,031 newly diagnosed non metastatic PCa patients, 5,155 harbored incidental PCa. Annual rates of incidental PCa increased from 1.9% (2004) to 2.5% (2015; p = 0.02). PSA values at diagnosis were 0–4 ng/ml in 48% vs. 4–10 ng/ml in 31% vs. > 10 ng/ml in 21%. Of all incidental PCa patients, 64% harbored GS 6 vs. 25% GS 7 vs. 11% GS ≥ 8. Of all incidental PCa patients, 47% were aged < 70, 35% were between 70–79 and 18% were ≥ 80 years. Subsequently, 71% underwent no local treatment (NLT) vs. 16% radical prostatectomy (RP) vs. 14% radiotherapy (RT). Proportions of patients with NLT increased from 65 to 81% (p = 0.0001) over the study period (2004–2015). CSM-free survival at six years ranged from 58% in GS ≥ 8 patients with NLT to 100% in patients who harbored GS 6 and underwent either RP or RT.Conclusion: Incidental PCa in the United States is rare. Most incidental PCa patients are diagnosed in men aged less than 80 years of age. The majority of incidental PCa patients undergo NLT and enjoy excellent CSM.