bluuebunny/crossref_metadata_2025_split huggingface dataset:
Changing Trends Towards Herbal Supplements: An Insight into Safety
and Herb-drug Interaction
Authors: Rasheed Haamid , Ahmed Suhail , Sharma Alok 
Published: July 2023

Abstract:
Herbs have been used as sustenance and medicine for a very long time, often in
conjunction with other prescribed medications. Even though they are thought to be natural and
secure, many of these herbs can interact with other medications and cause potentially dangerous
adverse effects or decrease the benefits of the medication. The complex and diverse
pharmacological functions carried out by the active ingredients in herbs unavoidably alter the
pharmacokinetics of chemical drugs when administered in vivo. Drug transporter expression has a
direct impact on how medications are absorbed, distributed, metabolized, and excreted in living
organisms. Changes in substrate pharmacokinetics can affect the effectiveness and toxicity of a
drug when the active ingredients of a herb inhibit or stimulate the expression of transporters. By
reviewing published clinical and preclinical studies, this review aims to raise awareness of herbdrug
interactions and discuss their evidence-based mechanisms and clinical consequences. More
clinical information on herb-drug interactions is required to make choices regarding patient safety
as the incidence and severity of herb-drug interactions are rising due to an increase in the use of
herbal preparations globally.This review seeks to increase understanding of herb-drug interactions
and explore their evidence-based mechanisms and clinical implications by reviewing published
clinical and preclinical studies. The incidence and severity of herb-drug interactions are on the rise
due to an increase in the use of herbal preparations worldwide, necessitating the need for more
clinical data on these interactions in order to make decisions regarding patient safety. Healthcare
workers and patients will become more alert to potential interactions as their knowledge of
pharmacokinetic herb-drug interactions grows. The study's objective is to raise readers' awareness
of possible interactions between herbal supplements and prescription medications who regularly
take them.
B Vitamins as Adjunctive Treatment for Chronic Heart Failure
Authors: Dkhillon Dzhastyn , Samogulova Alina , Kolobov Boris 
Published: July 2023

Introduction:
Vitamin B deficiency causes cardiac hypertrophy, reduced cardiac contractility,
and arrhythmias.The purpose of this study is to perform a network meta-analysis of randomized
controlled trials of vitamin B supplements in a group of 150 patients who meet the eligibility
criteria.The study also aims to describe the effect of synthetic multivitamins (pyridoxine, folic acid,
and cyanocobalamin) on the laboratory findings reflecting the severity of chronic heart failure (cholesterol,
glucose, and fibrinogen).

Methods:
The experiment involved a group of people (150 individuals) diagnosed with chronic
heart failure with reduced left ventricular ejection fraction. The study compared serum levels of B
vitamins measured after the therapy and at baseline. The second part of the study focused on the
assessment of the laboratory findings reflecting the severity of cardiovascular pathology and indicating
an increased risk of vascular catastrophes.

Results:
Clinical trials among patients diagnosed with chronic heart failure showed that the intake of synthetic
forms of pyridoxine, folic acid, and cyanocobalamin slightly increases systolic, diastolic and central
venous pressure while decreasing the heart rate and increasing LVEF. Thiamine acts as a vasodilator. It
reduces the cardiac afterload and improves heart function.

Conclusion:
The results obtained can be useful in terms of improving the comprehensive treatment
strategy for chronic heart failure and further investigation of the effects produced by the intake of B
vitamins.
The Global Prevalence of Nonalcoholic Fatty Liver Disease and its Association With Cancers: Systematic Review and Meta-Analysis
Authors: Muhamad Nor Asiah , Maamor Nur Hasnah , Leman Fatin Norhasny , Mohamad Zuraifah Asrah , Bakon Sophia Karen , Abdul Mutalip Mohd Hatta , Rosli Izzah Athirah , Aris Tahir , Lai Nai Ming , Abu Hassan Muhammad Radzi 
Published: July 2023

Background
Nonalcoholic fatty liver disease (NAFLD) is one of the common causes of chronic liver disease globally. Obesity, metabolic diseases, and exposure to some environmental agents contribute to NAFLD. NAFLD is commonly considered a precursor for some types of cancers. Since the leading causes of death in people with NAFLD are cardiovascular disease and extrahepatic cancers, it is important to understand the mechanisms of the progression of NAFLD to control its progression and identify its association with extrahepatic cancers. Thus, this review aims to estimate the global prevalence of NAFLD in association with the risk of extrahepatic cancers.

Objective
We aimed to determine the prevalence of various cancers in NAFLD patients and the association between NAFLD and cancer.

Methods
We searched PubMed, ProQuest, Scopus, and Web of Science from database inception to March 2022 to identify eligible studies reporting the prevalence of NAFLD and the risk of incident cancers among adult individuals (aged ≥18 years). Data from selected studies were extracted, and meta-analysis was performed using random effects models to obtain the pooled prevalence with the 95% CI. The quality of the evidence was assessed with the Newcastle-Ottawa Scale.

Results
We identified 11 studies that met our inclusion criteria, involving 222,523 adults and 3 types of cancer: hepatocellular carcinoma (HCC), breast cancer, and other types of extrahepatic cancer. The overall pooled prevalence of NAFLD and cancer was 26% (95% CI 16%-35%), while 25% of people had NAFLD and HCC (95% CI 7%-42%). NAFLD and breast cancer had the highest prevalence out of the 3 forms of cancer at 30% (95% CI 14%-45%), while the pooled prevalence for NAFLD and other cancers was 21% (95% CI 12%-31%).

Conclusions
The review suggests that people with NAFLD may be at an increased risk of cancer that might not affect not only the liver but also other organs, such as the breast and bile duct. The findings serve as important evidence for policymakers to evaluate and recommend measures to reduce the prevalence of NAFLD through lifestyle and environmental preventive approaches.

Trial Registration
PROSPERO CRD42022321946; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=321946
Identifying and Addressing Barriers and Facilitators for the Implementation of Internet of Things in Distributed Care: Protocol for a Case Study
Authors: Palm Klas , Kronlid Carl , Brantnell Anders , Elf Marie , Borg Johan 
Published: July 2023

Background
The internet of things (IoT) is recognized as a valuable approach to supporting health care to achieve quality and person-centered care. This study aims to identify the facilitators and barriers associated with implementing IoT solutions in health care within a Scandinavian context. It addresses the pressing need to adapt health care systems to the demographic changes occurring in Scandinavia. The vision of “Vision eHealth 2025,” a long-term strategic direction for digitalization in Sweden, serves as the background for this project. The implementation of IoT solutions is a crucial aspect of achieving the vision’s goal of making Sweden a global leader in using digitalization and eHealth opportunities by 2025. IoT is recognized as a valuable approach to supporting health care to achieve quality and person-centered care. Previous research has shown that there is a gap in our understanding of social and organizational challenges related to IoT and that the implementation and introduction of new technology in health care is often problematic.

Objective
In this study, we will identify facilitating and hindering factors for the implementation of IoT solutions in social and health care.

Methods
We will use an explorative design with a case study approach. The data collection will comprise questionnaires and qualitative interviews. Also, a literature review will be conducted at the start of the project. Thus, quantitative and qualitative data will be collected concurrently and integrated into a convergent mixed methods approach.

Results
As of June 2023, data for the review and 22 interviews with the stakeholders have been performed. The co-design with stakeholders will be performed in the fall of 2023.

Conclusions
This study represents a unique and innovative opportunity to gain new knowledge relevant and useful for future implementation of new technology at health care organizations so they can continue to offer high-quality, person-centered care. The outcomes of this research will contribute to a better understanding of the conditions necessary to implement and fully use the potential of IoT solutions. By developing cocreated implementation strategies, the study seeks to bridge the gap between theory and practice. Ultimately, this project aims to facilitate the adoption of IoT solutions in health care for promoting improved patient care and using technology to meet the evolving needs of health care.

International Registered Report Identifier (IRRID)
DERR1-10.2196/44562
An Detailed Overview on Mouth Dissolving Film
Authors: Jain Priyanshi , Gupta Ashish , Darwhekar Gajanan 
Published: July 2023

The present review aims to enlighten about a potential dosage form that is mouth dissolving films. Mouth dissolving film is a rapidly dissolving dosage form that dissolves in the mouth within a few seconds without the intake of water and is mainly used for pediatric and geriatric patients due to its flexibility and patient compliance. It is a potential dosage form for drugs having high metabolism and low bioavailability. Solvent casting, hot melt extrusion, solid dispersion, semisolid casting, rolling, and other processes can all be used to create mouth dissolving film, but solvent casting is the most popular due to its consistency and superior physical properties. Mouth dissolving film is evaluated for the following parameters like physical parameters and chemical parameters. The review sums up information on drug delivery by mouth dissolving films as a promising dosage form for delivering drugs to children and elderly patients, as well as information on its formulation considerations, preparation process, and evaluation criteria.
Keywords: Mouth dissolving film, Buccal film, Improved patient compliance, Standard composition, Method of preparation, Evaluation
Zmiany w otoczeniu makroekonomicznym rolnictwa w krajach Mercosur w długim okresie (1995-2011)
Authors: Czyżewski Andrzej , Kułyk Piotr 
Published: July 2023

Celem artykułu jest przedstawienie zmian zachodzących w polityce gospodarczej i uwarunkowaniach makroekonomicznych państw poddanych procesowi integracji gospodarczej. Ocena została przeprowadzona w odniesieniu do regionalnego ugrupowania Mercosur i obejmowała 17. lat (1995-2011). Wskazano na istniejące różnice między krajami ugrupowania a także pokazano, iż mamy do czynienia ze zbieżnością dotyczącą warunków makroekonomicznych, co pozwoliło uzyskać podobne efekty w rolnictwie aczkolwiek w różnej skali. Warunki makroekonomiczne powodowały asymetryczność dostosowań rolnictwa w badanych krajach.
Intensywność handlu rolno-żywnościowego wybranych regionalnych ugrupowań handlowych relacji Południe-Południe
Authors: Sapa Agnieszka 
Published: July 2023

Charakterystyczną cechą współczesnych międzynarodowych relacji handlowych jest rosnąca liczba regionalnych porozumień handlowych. W procesie tym coraz częściej uczestniczą kraje tzw. globalnego Południa. Utworzenie ugrupowania wiąże się między innymi ze zmianą kierunku przepływów handlowych. Głównym celem opracowania jest identyfikacja kierunku handlu rolno-żywnościowego regionalnych ugrupowań handlowych relacji Południe-Południe (CACM, CAN, EAC, MERCOSUR) w świetle wybranych wskaźników regionalnych współzależności handlowych. W wyniku przeprowadzonej analizy stwierdzono, że handel rolno-żywnościowy we wszystkich badanych ugrupowaniach w większym stopniu ukierunkowany jest na kraje członkowskie niż na kraje trzecie. Różnice pomiędzy ugrupowaniami dotyczą zmian tego ukierunkowania. Specjalizacja kierunkowa umacniała się w przypadku CACM i CAN, pozostawała bez zmian dla krajów EAC, a zmniejszyła się dla MERCOSUR.
Evaluation of Soil Rocky Desertification in Karst Region Based on Deep Belief Network
Authors: Lu Guan-Yao , Xu Dan , Meng Yue 
Published: July 2023

Abstract
Dynamic features from remote sensing photos may be successfully extracted using deep learning and symmetric network structure, which can then be used to direct them to carry out accurate classification. The DBN model can more effectively extract features from photos since it uses unsupervised learning. It can be reduced to the many symmetric Restricted Boltmann Machines (RBM) training problem. In this paper, a soil rocky desertification (RD) assessment model based on a deep belief network (DBN) is created in light of the complicated influencing aspects of Karst RD risk assessment encompassing several geographical elements. The model builds upon the conventional RBM framework and incorporates the influence layer of related elements as an auxiliary requirement for retrieving Geographic Information System (GIS) score data. Then, in order to forecast the level of soil rocky desertification, it learns the features of many elements. The experimental results show that the proposed model proposed in this paper has better prediction performance and faster convergence speed, and its classification results for different degrees of RD are more consistent with the actual risk assessment results.
Analysis of the Importance of Arts and Crafts in the Ecological Environment Construction in the New Era
Authors: Yang Shuwen , Li Nan , Wu JianHua , Hua YongMing 
Published: July 2023

Abstract
For a long time, people tended to ignore the carrying capacity of the environment, resources, ecology and other natural systems, and also ignore the resource and environmental costs and natural costs incurred by economic growth, which eventually leads to the degradation of natural ecological environment and the decline of residents’ health. The results show that the pollution indexes of environmental art design range from 0.007 (comprehensiveness) to 0.912 (economic value), and those of ecological protection strategy range from 0.113 (industrial development) to 0.704 (innovative design); the carrying capacities of environmental art design range from 0.010 (space arrangement) to 0.684 (sustainability) and those of ecological protection strategy range from 0.124 (social value) to 0.938 (industrial development); the environment-protection factor of environmental art design range from 0.085 (sustainability) to 0.544 (land use) and those of ecological protection strategy range from 0.005 (aesthetic value) to 0.937 (concept presentation). Therefore, the arts and crafts in ecological environment construction in the new era can effectively and scientifically implement and carry out the landscape-site selection, material selection, land use, concept presentation, space planning, innovative design and so on under the guidance of ecological civilisation concept. The research results of this paper provide a reference for further research on the analysis of the importance of arts and crafts in the construction of an ecological environment in the new era.
An Empirical Study on Emissions Trading Influence for the Enterprise Environmental Responsibility
Authors: Zhao Jing-Xuan 
Published: July 2023

Abstract
The primary objective of this paper is to address the inherent biases in the calculation of carbon emissions trading (CET) and foster the development of green innovation. By employing panel data from carbon emission trading pilots, the spatial Durbin model (SDID) is applied to assess the impact of CET on corporate environmental responsibility. By integrating CET and corporate environmental responsibility within a unified framework, this paper presents a novel analysis of the influence of environmental regulations on corporate environmental responsibility at the micro-level. Additionally, this study examines the spatial spillover effect of CET, thereby rectifying estimation biases. The model validation results indicate statistical significance below the 1 % level. The findings of this research reveal that it analyses the specific channels through which CET influences corporate environmental responsibility, providing insights that address the limitations of previous studies in mechanism analysis.
Research on Ecologicultural Environment Under the Background of Rural Revitalisation
Authors: Kai Chen , Asmi Fahad 
Published: July 2023

Abstract
In order to improve the development of rural areas, ecological agriculture has certain advantages because it is a comprehensive and complex type of agricultural industry. As the main force in the implementation of Rural Revitalisation (RurR) and ecological agriculture, farmers’ ecological consciousness plays a crucial role in the final realisation of RurR strategy and the construction of ecological agriculture. This paper conducted a questionnaire survey on 1010 farmers in 8 districts of city A, and studied the ecological knowledge, ecological seriousness and attribution of ecological problems of farmers. Combined with the relevant research results, this paper formulated three strategies to promote the development of efficient ecological agricultural environment: strengthening rural ecological publicity, vigorously developing ecological agriculture, and actively giving play to the guiding role of the government.
Analyzing Impact Behaviour of Glass Fiber Epoxy Composites for Higher Safety Systems
Authors: Păduraru Iulian , Ojoc George Ghiocel , Păduraru-graur Iulia , Petrescu Horia , Deleanu Lorena 
Published: July 2023

Abstract
This study investigates the impact behaviour of glass fiber epoxy composites with a focus on achieving enhanced safety. A drop weight impact test machine was used to perform a series of impact tests on the composite samples. Two different impactors as dimensions and three velocities were used to investigate the impact behavior of glass fiber epoxy composites. The study’s goal is to investigate the impact response of these composites and their potential for usage in impact protection applications. The study findings show that glass fiber epoxy composites have outstanding impact resistance properties, as well as high levels of the ability to absorb energy and withstand the initiation of damage. The findings suggest that both the impactor (as shape and dimensions) and the velocity of impact have a notable influence impact on the damage mechanisms and energy absorption capacity of the composite materials. The failure mechanisms detected in the composites were mostly delamination and fibre breakage.
Machine-Learning-Based Classification of Frequency Hopping in Radio Networks for Communication Reconnaissance
Authors: Sârbu Annamaria , Șorecău Mirela , Șorecău Emil , Bechet Paul 
Published: July 2023

Abstract
This article presents a customized approach for training a supervised learning neural network with the adaptive moment estimation algorithm, to classify the number of frequency hopping networks in an operational area. The algorithm was constructed based on data experimentally collected from a real-time spectrum analyzer for military very high frequency hopping networks. The impact of some training parameters on classification efficiency is briefly discussed while the obtained accuracy was above 97% for both test and validation data in all training variations. With this promising result, the proposed algorithm has the potential to be utilized in developing operational systems capable of real-time signal reconnaissance for military frequency hopping radio networks.
Advanced Military Radio Channels Monitoring System Based on Software Defined Radio Platform: Preliminary Analysis
Authors: Șorecău Emil , Șorecău Mirela , Vasile Alexandru-Marius , Bechet Paul 
Published: July 2023

Abstract
The use of electromagnetic spectrum monitoring for military emissions is essential due to the mobility and diversity of military operations. A tactical communications system used in the military domain includes encrypted and unencrypted data, voice and video communications using wideband and narrowband waveforms. This research focuses on the development of a high capability monitoring system based on Software-Defined Radio (SDR) technology for monitoring military waveforms. The implemented system has been tested for its ability to detect both wideband military waveforms and narrowband frequency hopping waveforms. The proposed SDR-based system provides a cost-effective solution for military waveform monitoring that can be used for real-time monitoring and analysis of the electromagnetic spectrum.
Estimation of Output Voltage Ripple in Phase-Staggered Series-Connected Two-Quadrant Power Converters for Electromagnets in Particle Accelerators
Authors: Rohidas Pokharkar Rahul , Borage Mangesh , Singh Alok , Dwivedi Vineet Kumar , Srivastava Abhishek 
Published: July 2023

Abstract
In booster synchrotron, fast-ramped power converters (FRPCs) are used for ramping up the magnetic field of electromagnets connected in series, at a fast rate, typically 1,000s of ampere per second. In large accelerators, the number of electromagnets is large. Therefore, during ramping, the peak value of driving voltage becomes prohibitively large considering the insulation requirement of the magnets and cables. The power converter is therefore developed by connecting a suitable number of smaller voltage rated modules in series. The series-connected modules are operated in phase-staggered mode to reduce the output voltage ripple or to reduce the filtering requirement to meet the prescribed ripple voltage. Since the filter component values predominantly decide the dynamic response, the achievable small-signal bandwidth of the control loop and hence the achievable tracking accuracy of the ramping output current are essentially governed by the filter components. To optimise the filter design, quantification of overall ripple voltage is crucial, that too under the most practical conditions considering non-ideal conditions. In this paper, estimation of overall ripple voltage is performed for series-connected two-quadrant power converters (TQPCs) operating in phase-staggering mode for ideal and non-ideal conditions. Simulation and experimental verification results are shown to be in good agreement with the analytical results.
Segmentation and Quantitative Analysis of Normal and Apoptotic Cells from Fluorescence Microscopy Images
Authors: Du Yuncheng , Budman Hector , Duever Thomas 
Published: July 2023

<p>Accurate and fast quantitative analysis of living cells from fluorescence microscopy images is useful for evaluations of experimental outcomes and cells culture protocols. An algorithm is developed in this work to automatically segment and discern apoptotic cells from normal cells. A <em>coarse segmentation</em> algorithm is proposed as a pre-filtering step that combines a range filter with a marching square method. This step provides approximate coordinates of cells’ positions in a two-dimensional matrix used to store cells’ image. With this information, the <em>active contours without edges</em> method is applied to identify cells’ boundaries and subsequently it is possible to extract the mean value of intensity within the cellular regions, the variance of pixels’ intensities in the vicinity of cells’ boundaries and the lengths of the boundaries. These morphological features are then employed as inputs to a support vector machine (SVM) classifier that is trained to distinguish apoptotic from normal viable states of cells. The algorithm is shown to be efficient in terms of computational time, quantitative analysis and differentiation accuracy, as compared to the use of the active contours method without the proposed <em>coarse segmentation</em> step.</p>
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