bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of Static Magnetic Field on In Ovo Angiogenesis and In Vitro Cell Migration
Authors: Dini Jagath Jayakumar , Purayil Kiran Santh Puthiya , Parsanathan Rajesh 
Published: May 2023

Abstract
Static magnetic field (SMF) therapy has been proven effective in various tissue repairs. Diamagnetic anisotropy may induce SMF to impact biological macromolecules. The formation of new blood vessels, or angiogenesis, is essential for many pathophysiological processes, including development, reproduction, tumour growth, and metastasis. Inhibiting angiogenesis is one of the key objectives in the fight against cancer and other diseases. The mechanism underlying SMF-mediated regulation of angiogenesis and fibroblast migration is still unclear. Thus, the goal is to investigate the influence of SMF on avian angiogenesis using the chorioallantois membrane (CAM) experiment and murine fibroblast migration. Gallus gallus fertilised eggs were placed in an incubator from day 3 to 7 to the isocentre of the Neodymium Magnet block (30 milli Tesla (mT); North-pole or upward; SMF+) was exposed, and control eggs were placed in a separate incubator (SMF-). On day 7, the angiogenesis or neovascularisation vascular parameters were analysed using a stereoscope and AngioTool. SMF+ stimulation showed a statistically significant decrease in vascular parameters compared to the control. Additionally, the effect of SMF+ on murine fibroblast cell viability, ROS, and migration was explored. Compared to unexposed cells, SMF+ stimulation showed a statistically significant decrease in cellular ROS production and migration after 24 hours without a change in cell viability. These findings imply that SMF could be an effective adjuvant therapy for limiting or preventing excessive ROS, angiogenesis, and fibroblast migration; this effect may be utilised to treat cancer, diabetic retinopathy, and other disorders that entail excessive pathological angiogenesis.
An Efficient Early Diagnosis and Healthcare Monitoring System for Mental Disorder using Machine learning Approach
Authors: Reddy C Kishor Kumar , Satvika Pullisani 
Published: May 2023

Abstract
Recently, the increase in internal health problems in society has led to an increase in research on the development of mechanistic capacity models to detect or predict internal mental health. The effective use of internal health assessments or discovery models allows internal health interpreters to redefine internal suffering more objectively than ever before, and in the early stages when interventions may be more effective.In this work, we aim to apply a bias mitigation system based on multitasking literacy to perform a fairness analysis and to fear the predicted model using the Reddit dataset. This article employs an efficient technique for machine learning random forests. The proposed model was evaluated against various performance metrics and the model showed 91.00% accuracy. This is an advantage compared to existing approaches.
Prediction of Skull Fractures in Blunt Force Head Traumas using Finite Element Head Models
Authors: Lindgren Natalia , Henningsen Mikkel J. , Jocobsen Christina , Villa Chiara , Kleiven Svein , Li Xiaogai 
Published: May 2023

Abstract
Traumatic head injuries remain a leading cause of death and disability worldwide. Although skull fractures are one of the most common head injuries, the fundamental mechanics of cranial bone and its impact tolerance is still uncertain. In the present study, a strain-rate-dependent material model for cranial bone has been proposed and implemented in subject-specific FE head models in order to predict skull fractures in five real-world fall accidents. The subject-specific head models were developed following an established image-registration-based personalization pipeline. Head impact boundary conditions were derived from accident reconstructions using personalized human body models. The simulated fracture lines were compared to those visible in post-mortem CT scans of each subject. In result, the FE models did accurately predict the actual occurrence and extent of skull fractures in all cases. In at least four out of five cases, fracture patterns were predicted in agreement with CT scans and autopsy reports. The material model reproduced the mechanical response of cortical bone in tension, while correctly capturing failure mechanisms in blunt indentation loading of a skullcap specimen. The FE model showed to be sensitive to modelling parameters, in particular to the constitutive parameters of the cortical tables.Nevertheless, this study provides a currently lacking strain-rate dependent material model of cranial bone that has the capacity to accurately predict linear fracture patterns. For the first time, a procedure to reconstruct occurrences of skull fractures using computational engineering techniques, capturing the all-in-all fracture initiation, propagation and final pattern, is presented.
Effectiveness of lotilaner on furuncular myiasis in dogs naturally infested with Dermatobia hominis (Diptera: Cuterebridae)
Authors: Tortoriello Rafaella , Christ Luisa Xavier , Manier Bruna Sampaio Martins Land , Fernandes Julio I. 
Published: May 2023

Abstract
Background This study aimed to evaluate lotilaner (Credeli®)’s larvicidal efficacy in the treatment of dogs naturally infested with Dermatobia hominis larvae.Methods A total of 12 dogs that naturally presented at least three live D. hominis larvae were medicated. All the animals could not have undergone any type of insecticide or acaricide and/or larvicidal treatment in a period before 90 days, as an inclusion criterion. The animals were medicated with a single dose of at least 20 mg/kg lotilaner in the oral formulation, following the recommendations in the package insert for other ectoparasitic treatments. After drug administration, the animals remained at their homes, and observations were made to verify the larvicidal effect 6 h after treatment, in addition to possible adverse effects on the medicated animals. Live larvae were considered as any parasite that showed motility after removal. The effect was calculated for each animal using the formula: [100 × (number of live larvae before treatment − number of live larvae after treatment/number of live larvae before treatment)] as criteria for evaluating lotilaner efficacy.Results A total of 98 larvae were counted in 12 dogs, with an average of 8.1 larvae per animal. The majority of the parasites, that is, 38 larvae, were found in the animals’ dorsal region. Lotilaner’s effectiveness was 80.6%. No animal showed adverse effects or changes in behavior after isoxazoline use. Nineteen larvae were found alive, presenting hypomobility and lethargic behavior. Notably, the evaluation only lasted for 6 h.Conclusion Lotilaner, when orally administered in a single dose of 20 mg/kg, is effective in the treatment of dogs naturally infested by D. hominis.
Multi-Modal Imaging-Based Feature Fusion for Accurate Glaucoma Diagnosis with Deep Learning
Authors: Krishna Nanditha , Nagamani K 
Published: May 2023

Abstract
Glaucoma, a leading cause of irreversible blindness worldwide, affects over 76 million people currently and is projected to increase to 111.8 million by 2040 according to the World Health Organization. Glaucoma is often asymptomatic and progresses gradually, making early detection and treatment crucial to prevent irreversible vision loss. Ophthalmologists commonly use eye analysis machines such as ophthalmoscopy and fundus photography to obtain scans for accurate diagnosis and treatment of glaucoma. However, clinical-decision support techniques in medical imaging face challenges in interpretability and reliability. To overcome these challenges and accurately detect glaucoma, this study presents a novel Fire Hawk Optimized Deep Learning Based Retinal Disease Grading and Classification (FHODLB-RDGC) utilizing multi-modal feature fusion from Optical Coherence Tomography (OCT) and Fundus images. Radiomics features for OCT images using DL Technique and cup-to-disc ratio for fundus images using NestNet model are extracted using Deep Learning (DL) techniques and merged. The proposed FHODLB-RDGC technique is of great interest in the field of ophthalmology and has demonstrated enhanced retinal disease classification results in extensive simulations on a benchmark database, particularly in accurately diagnosing glaucoma. Therefore, glaucoma, a severe and potentially blinding retinal disease, has the potential of being more accurately recognised and treated early on owing to the FHODLB-RDGC technique.
Is it possible to stop the osteolysis of the periprosthetic bone during re-endoprosthetics of the hip joint against the background of osteoporosis?
Authors: Rodionova S. S. , Makarov M. A. , Balychev G. E. , Torgashin A. N. 
Published: May 2023

Revision interventions due to aseptic instability show a marked upward trend, and one of the reasons is an increase in the number of people with osteoporosis in the population. The impaired bone metabolism in these cases persist even after re-endoprosthetics. The authors aim to draw attention of trauma orthopaedists to the need to treat osteoporosis either before or immediately after the re-endoprosthetic surgery. A clinical case is presented. A 65-year-old patient T., 5 months after surgery, complained of persistent pain in the left hip joint radiating to the left knee joint, which intensified when walking, lameness, inability to move without additional support (two crutches), limited range of motion within the left hip joint that had undergone surgery (endoprosthesis). The patient had a history of femoral neck fracture associated with a low energy fall. The left hip joint re-endoprosthetics was performed due to aseptic instability of the femoral and acetabular components of the prosthetic implant. The diagnosed diseases included secondary osteoporosis, D-deficiency, hypocalcemia, and periprosthetic osteolysis. Given the increased intensity of resorption and the fact that the femoral neck fracture occurred with underlying secondary osteoporosis, it was decided to prescribe antiresorptive therapy with denosumab 60 mg once every 6 months combined with alfacalcidol and calcium supplement. Despite an objective 3-month delay in antiresorptive therapy initiation, the treatment result was achieved in the observed patient. In summary, denosumab 60 mg increases the effectiveness of re-endoprosthetics with underlying osteoporosis by reducing activity of the periprosthetic bone osteolysis.
Possibilities of sulodexide use in clinical practice
Authors: Morozov A. M. , Avanesyan A. E. , Boltik A. A. , Sergeev A. N. 
Published: May 2023

Introduction. Sulodexide is a polymer, the structure of which includes unbranched polysaccharide chains formed by repeating a particular disaccharide unit. This drug was isolated from the endothelium of the pig, and it appeared on the pharmaceutical market in 1974. Sulodexide contains ≈ 80% heparan sulfate (also known as fast-acting heparin) and 20% dermatan sulfate. This drug is produced from the more sulfated waste heparinoids. During production, heparin is chemically decomposed and transformed into the clinical drug Sulodexide. Aim. To estimate the possibilities and prospects of using the drug Sulodexid in the treatment of various diseases. Materials and methods. During this study, we analyzed relevant sources of domestic and foreign literature on the use of the drug Sulodexid in various pathologies. Sources of information included publications from the Russian scientific electronic library integrated with the Russian Science Citation Index, the Medline database, Scopus, Science Direct, Cyberleninka.ru, and the New England Journal of Medicine. Results and discussion. The pharmacological action of the drug is not limited to anticoagulant action, it also has antiaggregant and angioprotective effects. The drug has found application in various fields of medicine, such as pediatrics, surgery, therapy, endocrinology, neurology and proctology. The possibility of wide application is also promoted by the availability of different forms and methods of administration of this drug: intramuscular, infusion and oral, which allows prescribing the drug both in inpatient and outpatient settings. In contrast to other anticoagulants the drug has the most favorable action, since the risk of bleeding is low. Conclusion. In spite of a sufficiently wide use of the study drug in clinical practice, inclusion in the national clinical guidelines, other effects of the drug require further studies. It is difficult to make a conclusion about the efficacy of the drug in the treatment of some diseases, but with further studies, there is a chance of including it in the therapy of different pathological conditions.
Topical glucocorticosteroids: from high clinical efficacy to the problem of uncontrolled use (case report)
Authors: Tlish M. M. , Shavilova M. E. , Sycheva N. L. , Psavok F. A. 
Published: May 2023

Due to their pronounced biological activity, glucocorticosteroids are widely used in various fields of medical practice. The variety of effects of these hormones makes them an important part of the treatment of dermatological patients. This group of drugs has a pronounced positive effect on various links in the pathogenesis of many chronic dermatoses due to anti-inflammatory, vasoconstrictive, immunosuppressive and antiproliferative effects. The creation of combined external preparations containing a glucocorticosteroid in combination with an antibacterial and/or antifungal component has become a significant achievement in dermatological practice. Due to the rapid relief of signs of inflammation, as well as additional antibacterial and antifungal effects, these external agents have become especially attractive to patients. Widespread advertising and over-the-counter sale of drugs containing glucocorticosteroids leads to the fact that a significant part of patients seek advice from a dermatologist only after their ineffective use. At the same time, their uncontrolled use can lead to a number of side effects, including both pathological changes in the skin and pronounced negative systemic reactions. This fact significantly changes the clinical picture of the disease, limits the possibilities of early laboratory diagnosis of infection, which often prolongs the time for verification of the diagnosis and complicates therapy. The article presents our own clinical observations of patients with skin mycoses who have been using combined topical preparations containing glucocorticosteroids for a long time. This led to an atypical clinical course of the infection and required additional diagnostics using histological examination. The analysis of clinical observations is intended to focus the attention of primary care physicians on this problem, which can increase patient awareness of the risks of using topical drugs containing glucocorticosteroids.
Bioequivalence and immunogenicity of insulin LisPro biosimilar compared to reference drug
Authors: Karonova Т. L. , Chernikova A. Т. , Mayorov A. Y. 
Published: May 2023

Introduction. Insulin therapy is the only treatment for type 1 DM and one of the options for intensifying the treatment for type 2 DM. The production of own insulin biosimilars will increase patients access to the providing drugs and can potentially reduce medical costs on healthcare for government. Aim. Compare the equivalence of pharmacokinetics (PK) and pharmacodynamics (PD), safety, efficacy, and immunogenicity between insulin biosimilar RinLis®, 100 IU/ml (LLC GEROPHARM, Russia) to original Humalog®, 100 IU/ml (Lilly France, France). Materials and methods. The clinical trial was conducted in two phases. Phase I – randomized double-blind, two-arm crossover study of PK and PD using hyperinsulinemic euglycemic clamp (HEC) method in 28 healthy volunteers (NCT03604575). During HEC regular blood sampling was performed to assess glucose and insulin concentrations. The glucose infusion rate (GIR) was adjusted based on glycemia measurement. These data were used to calculate the PD parameters: the total area under the GIR-time curve (AUCGIR) and the maximum GIR over the observation period (GIRmax); PK parameters: the total area under the concentration – time curve (AUCins.) and the maximum insulin concentration over the HEC (Сins. max). Phase II – randomized multicenter open-label comparative study in parallel groups with an assessment the frequency of an immune response after 26 weeks of therapy (NCT04023344). The comparability of the studied drugs was considered proven if 90% confidence intervals (CI) for the ratio of geometric means of FC and PD were in the range of 80–125%. Results. In the course of the study, it was revealed that RinLiz® and Humalog® insulin had comparable PK and PD profiles. The ratio of the geometric mean values of the AUCGIR and GIRmax were in the range of 80–125% and amounted to 106 [95–118] % and 108 [97–121] %, respectively. The equivalence also was confirmed by the ratio of the geometric mean values of the AUCins. and Сins. max, which amounted to 91 [86–97] % and 94 [91–97] %. In the second phase of the study after 26 weeks of therapy the frequency of immune response between two groups did not differ. Conclusion. The obtained data have demonstrated the bioequivalence and immunogenicity of RinLiz® insulin to the original Humalog® in terms of PK, PD and safety parameters.
Features of neuropsychological characteristics of patients with arterial hypertension
Authors: Shishkova V. N. , Dranitsyna B. G. , Ustarbekova D. B. , Ishchuk A. G. , Kapustina L. A. 
Published: May 2023

Introduction. The significant pathogenetic effect of arterial hypertension on the development of cognitive and psycho-emotional disorders, on the one hand, and the lack of algorithms for identifying and managing patients with comorbid neurocognitive disorders in therapeutic practice, on the other hand, determines the relevance of studying this problem.Aim. To study neuropsychological characteristics of patients with arterial hypertension in therapeutic practice. Materials and methods. A total of 508 patients with arterial hypertension were enrolled in the study. All study participants underwent the clinical examination and neuropsychological tests: Montreal Cognitive Assessment Scale (MoCA test), Schulte tables, Categorical Verbal Fluency Test, Tracking Test, MFI-20 asthenia self-assessment questionnaire, Reeder's Test, Maastricht Questionnaire, and Hospital Anxiety and Depression Scale (HADS). Results. The analysis of neuropsychological testing results of patients with hypertension showed that almost all the techniques identified deviations from the reference ranges in most of the study subjects. 85% of patients had decreased total score of cognitive functions assessed in terms of MoCA test scores, 83% of patients showed increased time in performing tracking test part A and 74% patients showed increased time in performing part B, and there was also a large difference between the time spent on performing parts B and A of the test; 49% of patients demonstrated decreased speed in performing the Schulte test. Th psycho-emotional state test results showed a high level of psycho-emotional stress in 80.5%, vital exhaustion in 78% and fatigue in 96% of patients. Conclusions. In this study, the neuropsychological testing results of patients with hypertension showed decreased total scores of cognitive functions and individual parameters of the cognitive spectrum, such as attention focusing, information processing speed, memory, speech function and executive functions combined with a high level of psycho-emotional stress, fatigue and anxiety.
Possibilities of using nimesulide in clinical practice, features of use in dorsopathy
Authors: Yakovlev E. V. , Gnevyshev E. N. , Achkasov E. E. , Butko D. Y. , Davydov A. T. , Smirnov A. A. , Figurin I. S. 
Published: May 2023

Nonsteroidal anti-inflammatory drugs (NSAIDs) are a structurally diverse group of drugs with a common mechanism of action (reversible inhibition of cyclooxygenase). They are widely used due to their analgesic, antipyretic and anti-inflammatory properties; available both as prescription and over-the-counter medications; available as individual pharmaceuticals, compound painkillers. The methods of treatment of acute and chronic pain are different. For acute pain, analgesics such as nonsteroidal anti-inflammatory drugs and opiates are commonly used, sometimes in combination with regional anesthesia such as peripheral nerve blockade or peridural local anesthesia. A systematic review and meta-analysis of the efficacy and safety of nimesulide published in the sources MEDLINE/PubMed, Embase, Cochrane Library and China National Knowledge Infrastructure. The efficacy and safety of the use of nimesulide in clinical practice is shown. In particular, in the treatment of acute musculoskeletal pain (dorsopathy of the cervical-thoracic and lumbar region), as well as migraines, due to a decrease in the release of calcitonin- gene related peptide (CGRP) and prostaglandin E2 (PGE2) from the trigeminal ganglia, while other NSAIDs have shown a lack of efficacy. Noncompliance with international guidelines, irrational use of NSAIDs among all groups of drugs is one of the leading causes of hospitalizations associated with side effects, which increases health care costs. The article presents an overview of the safety and efficacy of medicines containing nimesulide, as well as recommendations for patients and prescribers of this drug.
Pathomorphology of cutaneous mastocytosis
Authors: Kasikhina E. I. , Potekaev N. N. , Katunina O. R. , Ostretsova M. N. , Zhukova O. V. , Mednikova M. A. 
Published: May 2023

Introduction. Mastocytosis as a result of mast cell infiltration of the skin and other organs develops at any age. The relevance of this work is determined by the lack of systematic data on the pathomorphological features of the clinical forms and types of cutaneous mastocytosis, defined by the Consensus European-American Mastocytosis Group and the WHO classification in 2016. The variability of dermatological clinical manifestations in children and adults, the difficulties in interpreting laboratory tests create a problem for verifying the diagnosis and further treatment. The aim. To determine the main pathohistological features of clinical forms and types of cutaneous mastocytosis. Material and methods. The article includes data from patients who were treated and monitored at the Moscow Scientific and Practical Center of Dermatovenereology and Cosmetology in 2019–2022. Results. The literature and own data on the characteristic pathomorphological patterns that are important for the diagnosis of mastocytosis with skin lesions in children and adults are systematized. The pathological substrate of lesions in diffuse cutaneous mastocytosis and mastocytoma was a massive infiltrate of mast cells in the papillary and reticular layers of the dermis. The histological picture in the monomorphic type of maculopapular cutaneous mastocytosis (MPCM) in children was characterized by a relatively lower density of mast cell infiltration of the papillary dermis compared to other clinical forms of mastocytosis. Also, in children, the density of mast cells in the affected skin was significantly higher compared to adults. In addition, in adults with PPCM, the papillary dermis was less infiltrated with mast cells. This confirms the opinion that the monomorphic type of MPCM in children is phenotypically similar to MPCM in adults. Conclusions. Further prospective follow-up of patients may allow conclusions to be drawn about the prognostic value of pathological examination in mastocytosis in adults and children.