bluuebunny/crossref_metadata_2025_split huggingface dataset:
Health-care utilisation among India’s middle and older aged migrants: scrutinizing the status and predictors using Andersen’s simplified healthcare utilisation framework
Authors: Samanta Ramkrishna , Munda Jadab , Mandal Sourav , Adhikary Mihir 
Published: July 2023

Purpose
Migration appears to be a determinant in health-care utilisation, particularly among the elderly in India. Ageing and migration are essential socio-demographic phenomena in the 21st century for developing and developed countries to establish better public health-care policies. This study aims to focus on the status and determinants of health-care utilisation among elderly migrants who have migrated after attaining the age of 45 and above.

Design/methodology/approach
This study used the data from the first wave of the longitudinal ageing study in India (LASI) in 2017–2018. Two outcome variables were used to examine the health-care utilisation, including in-patient and out-patient care. Binary logistic regression was used to explore the predictors of healthcare utilisation in terms of in-patient and out-patient care among the elderly migrant population.

Findings
A total of 82.9% of elderly migrants had visited out-patient care when they were sick, whereas 15.3% have used in-patient care. Enabling factors, such as wealth quintile and health insurance, and need factor, such as chronic disease and self-rated health, were more significant factors influencing the health-care utilisation.

Originality/value
This study contributes to our understanding of older migrants’ health-care utilisation. Focussing on this study’s outcome, policymakers and decision makers may consider improving older migrants’ access to health-care by raising their income level, offering local health insurance and health awareness programs.
Physicians as leaders: a systematic review through the lens of expert leadership
Authors: Thoebes Gina Phelps , Porter Tracy H. , Peck Jessica A. 
Published: July 2023

Purpose
The purpose of this paper is to provide a systematic review of the current state of physician leadership. Theory of expert leadership (TEL) was applied to explore the effects of physician inherent knowledge, industry experience and leadership capabilities on leader behaviors and outcomes.

Design/methodology/approach
This review (August 2011–February 2022) applied the preferred reporting items for systematic review and meta-analysis strategy. Our search began with 3,537 studies and a final sample of 12 articles.

Findings
The findings offer a number of studies that note the relationship between physician leadership and the three dimensions of TEL. How influential these are on leadership behaviors and health-related outcomes varies. We also found a number of studies that described general physician leadership behaviors that were not directly linked to factors of TEL, as well as two additional themes: leader identity and trust.

Originality/value
To the best of the authors’ knowledge, this is the first systematic review that has applied a highly cited theory (i.e. TEL) to the data and the first that has focused solely on a U.S. population. These findings offer healthcare organizations insight into the potential strengths and challenges of physician leadership.
Information sharing offices and economic growth in sub‐Saharan Africa
Authors: Asiamah Oliver , Agyei Samuel Kwaku 
Published: July 2023

AbstractAlthough credit availability is essential for economic growth, the information asymmetry problem inhibits the credit creation function of financial institutions. Among other means, information‐sharing offices (ISOs) have been established, including private credit bureaus and public credit registries to provide information on the financial characteristics of citizens to reduce information asymmetry. From this background, this study used an explanatory research design with a longitudinal (panel) data approach to assess whether the coverage of information by ISOs affects sectorial and overall economic growth among sub‐Saharan African (SSA) countries using the system generalized method of moments technique on data from 2005 to 2019. The results highlight that information coverage by ISOs enhances sectorial and overall economic growth by solving the information asymmetry problem. From the findings, governments in SSA countries are encouraged to support public credit registries to effectively perform their mandate while providing incentives to attract investments in private credit bureaus since they contribute to economic growth.
Financial stability gap and private investment nexus: Evidence from sub‐Saharan Africa
Authors: Kulu Evans 
Published: July 2023

AbstractThe illiquidity status of financial institutions widens up the financial stability gap, hence affecting other economic agents that depend on the financial sector. The objective of the study is to determine how the financial stability gap affects private investment in sub‐Saharan Africa (SSA). Annual time series secondary data from 33 SSA countries for the period 2007–2018 was used. Using the general methods of moments (GMM) estimation technique, we found that the financial stability gap beyond 109.9% becomes detrimental to private sector investment while government effectiveness and investment by the government improve private investment. The study recommends that financial institutions undertake liquidity protection measures as a means of protecting the stability status, while SSA governments invest in the economy and provide the needed business environment for private sector investment.
Acute lesion extension following pulmonary vein isolation with two novel single shot devices: Pulsed field ablation versus multielectrode radiofrequency balloon
Authors: My Ilaria , Lemoine Marc D. , Butt Mahi , Mencke Celine , Loeck Fabian W. , Obergassel Julius , Rottner Laura , Wenzel Jan‐Per , Schleberger Ruben , Moser Julia , Moser Fabian , Kirchhof Paulus , Reissmann Bruno , Ouyang Feifan , Rillig Andreas , Metzner Andreas 
Published: July 2023

AbstractIntroductionPulsed‐field ablation (PFA) and the multielectrode radiofrequency balloon (RFB) are two novel ablation technologies to perform pulmonary vein isolation (PVI). It is currently unknown whether these technologies differ in lesion formation and lesion extent. We compared the acute lesion extent after PVI induced by PFA and RFB by measuring low‐voltage area in high‐density maps and the release of biomolecules reflecting cardiac injury.MethodsPVI was performed with a pentaspline catheter (FARAPULSE) applying PFA or with the compliant multielectrode RFB (HELIOSTAR). Before and after PVI high‐density mapping with CARTO 3 was performed. In addition, blood samples were taken before transseptal puncture and after post‐PVI remapping and serum concentrations of high‐sensitive Troponin I were quantified by immunoassay.ResultsSixty patients undergoing PVI by PFA (n = 28, age 69 ± 12 year, 60% males, 39.3% persistent atrial fibrillation [AF]) or RFB (n = 32, age 65 ± 13 year, 53% males, 21.9% persistent AF) were evaluated. Acute PVI was achieved in all patients in both groups. Mean number of PFA pulses was 34.2 ± 4.5 and mean number RFB applications was 8.5 ± 3 per patient. Total posterior ablation area was significantly larger in PFA (20.7 ± 7.7 cm²) than in RFB (7.1 ± 2.09 cm²; p < .001). Accordingly, posterior ablation area for each PV resulted in larger lesions after PFA versus RFB (LSPV 5.2 ± 2.7 vs. 1.9 ± 0.8 cm², LIPV 5.5 ± 2.3 vs. 1.9 ± 0.8 cm², RSPV 4.7 ± 1.9 vs. 1.6 ± 0.5 cm², RIPV 5.3 ± 2.1 vs. 1.6 ± 0.7 cm,² respectively; p < .001). In a subset of 38 patients, increase of hsTropI was higher after PFA (625 ± 138 pg/mL, n = 28) versus RFB (148 ± 36 pg/mL, n = 10; p = .049) supporting the evidence of larger lesion extent by PFA.ConclusionPFA delivers larger acute lesion areas and higher troponin release upon successful PVI than multielectrode RFB‐based PVI in this single‐center series.
Linear epicardial cryoablation effects in a porcine model: Lesion characteristics and vascular risk
Authors: Hayase Justin , Fishbein Gregory , Rerkpichaisuth Vilasinee , Chung Wei‐Hsin , Ajijola Olujimi , Shivkumar Kalyanam , Bradfield Jason S. 
Published: July 2023

AbstractIntroductionCryoablation in open‐chest surgical interventions for ventricular arrhythmias has been reported with reasonable procedural outcomes. However, the characteristics of cryoablation lesions on the ventricular myocardium are not well defined. The purpose of the present study was to determine the tissue and vascular effects of a linear epicardial cryoablation probe in a porcine animal model.MethodsFive adult Yorkshire swine underwent median sternotomy and application of linear cryoablation lesions using a malleable aluminum linear cryoablation probe of varying duration (2, 3, 4, and 5 min), including one lesion placed intentionally over the left anterior descending coronary (LAD) artery. Histological analysis was performed.ResultsMaximum lesion depth was approximately 1.0 cm with 3 min freezes, with no significant increase in depth achieved with longer lesions. No transmural lesions were achieved. No large vessel epicardial coronary artery injuries were seen to the LAD; however, surprisingly, remote isolated interventricular septal injury was seen in all animals, suggestive of possible compromise of smaller coronary arterial vessels.ConclusionSingle application freezes with an aluminum linear cryoablation probe can create homogeneous ablative lesions over the ventricular myocardium with a maximum depth of approximately 1.0 cm. No large vessel injury occurred with direct lesion application of the LAD; however, small coronary vessels may be at risk.
Cannabidiol and cannabidiolic acid: Preliminary in vitro evaluation of metabolism and drug–drug interactions involving canine cytochrome P‐450, UDP‐glucuronosyltransferase, and P‐glycoprotein
Authors: Court Michael H. , Mealey Katrina L. , Burke Neal S. , Jimenez Tania Perez , Zhu Zhaohui , Wakshlag Joseph J. 
Published: July 2023

AbstractPhytocannabinoid‐rich hemp extracts containing cannabidiol (CBD) and cannabidiolic acid (CBDA) are increasingly being used to treat various disorders in dogs. The objectives of this study were to obtain preliminary information regarding the in vitro metabolism of these compounds and their capacity to inhibit canine cytochrome P450 (CYP)‐mediated drug metabolism and canine P‐glycoprotein‐mediated transport. Pure CBD and CBDA, and hemp extracts enriched for CBD and for CBDA were evaluated. Substrate depletion assays using pooled dog liver microsomes showed CYP cofactor‐dependent depletion of CBD (but not CBDA) and UDP‐glucuronosytransferase cofactor‐dependent depletion of CBDA (but not CBD) indicating major roles for CYP and UDP‐glucuronosytransferase in the metabolism of these phytocannabinoids, respectively. Further studies using recombinant canine CYPs demonstrated substantial CBD depletion by the major hepatic P450 enzymes CYP1A2 and CYP2C21. These results were confirmed by showing increased CBD depletion by liver microsomes from dogs treated with a known CYP1A2 inducer (β‐naphthoflavone) and with a known CYP2C21 inducer (phenobarbital). Cannabinoid‐drug inhibition experiments showed inhibition (IC50 = 4.6–8.1 μM) of tramadol metabolism via CYP2B11‐mediated N‐demethylation (CBD and CBDA) and CYP2D15‐mediated O‐demethylation (CBDA only) by dog liver microsomes. CBD and CBDA did not inhibit CYP3A12‐mediated midazolam 1′‐hydroxylation (IC50 > 10 μM). CBD and CBDA were not substrates or competitive inhibitors of canine P‐glycoprotein. Results for cannabinoid‐enriched hemp extracts were identical to those for pure cannabinoids. These in vitro studies indicate the potential for cannabinoid–drug interactions involving certain CYPs (but not P‐glycoprotein). Confirmatory in vivo studies are warranted.
Creating inclusive schools to reduce health and well‐being disparities
Authors: Levine Cynthia S. , Bourne Kimberly A. , Song Rachel , Weltzien Katherine 
Published: July 2023

AbstractIn the U.S., people with marginalized racial/ethnic, social class, sexual, and gender identities often have worse physical and mental health than people with more privileged identities. This paper reviews psychological research suggesting that inclusive school cultures can improve the health and well‐being of those with marginalized identities. Specifically, we review two examples of sets of ideas and practices in schools that create more supportive environments: (a) ideas and practices that recognize and include diverse identities and (b) ideas and practices that support interdependent ways of thinking, feeling, and acting. We also speculate about the psychological and behavioral mechanisms by which each protects health and well‐being, including reducing discrimination, increasing school belonging, strengthening positive ingroup identities, and allowing students to access culturally relevant support. We suggest that changing school cultures to make them more inclusive is one way to reduce health and well‐being disparities.
A detailed analysis of single‐channel Nav1.5 recordings does not reveal any cooperative gating
Authors: Selimi Zoja , Rougier Jean‐Sébastien , Abriel Hugues , Kucera Jan P. 
Published: July 2023

AbstractCardiac voltage‐gated sodium (Na+) channels (Nav1.5) are crucial for myocardial electrical excitation. Recent studies based on single‐channel recordings have suggested that Na+ channels interact functionally and exhibit coupled gating. However, the analysis of such recordings frequently relies on manual interventions, which can lead to bias. Here, we developed an automated pipeline to de‐trend and idealize single‐channel currents, and assessed possible functional interactions in cell‐attached patch clamp experiments in HEK293 cells expressing human Nav1.5 channels as well as in adult mouse and rabbit ventricular cardiomyocytes. Our pipeline involved de‐trending individual sweeps by linear optimization using a library of predefined functions, followed by digital filtering and baseline offset. Subsequently, the processed sweeps were idealized based on the idea that the ensemble average of the idealized current identified by thresholds between current levels reconstructs at best the ensemble average current from the de‐trended sweeps. This reconstruction was achieved by non‐linear optimization. To ascertain functional interactions, we examined the distribution of the numbers of open channels at every time point during the activation protocol and compared it to the distribution expected for independent channels. We also examined whether the channels tended to synchronize their openings and closings. However, we did not uncover any solid evidence of such interactions in our recordings. Rather, our results indicate that wild‐type Nav1.5 channels are independent entities or exhibit only very weak functional interactions that are probably irrelevant under physiological conditions. Nevertheless, our unbiased analysis will be important for further studies examining whether auxiliary proteins potentiate functional Na+ channel interactions.
imageKey points
Nav1.5 channels are critical for cardiac excitation. They are part of macromolecular interacting complexes, and it was previously suggested that two neighbouring channels may functionally interact and exhibit coupled gating.
Manual interventions when processing single‐channel recordings can lead to bias and inaccurate data interpretation.
We developed an automated pipeline to de‐trend and idealize single‐channel currents and assessed possible functional interactions between Nav1.5 channels in HEK293 cells and cardiomyocytes during activation protocols using the cell‐attached patch clamp technique.
In recordings consisting of up to 1000 sweeps from the same patch, our analysis did not reveal any evidence of functional interactions or coupled gating between wild‐type Nav1.5 channels.
Our unbiased analysis may be useful in further studies examining how Na+ channel interactions are affected by mutations and auxiliary proteins.
Biomechanical Response of Head Surrogate With and Without the Helmet
Authors: Singh Abhilash , Kumar Devendra , Ganpule Shailesh 
Published: July 2023

Abstract
Measurements of brain deformations under injurious loading scenarios are actively sought. In this work, we report experimentally measured head kinematics and corresponding dynamic, two-dimensional brain simulant deformations in head surrogates under a blunt impact, with and without a helmet. Head surrogates used in this work consisted of skin, skull, dura, falx, tentorium, and brain stimulants. The head surrogate geometry was based on the global human body models consortium's head model. A base head surrogate consisting of skin-skull-brain was considered. In addition, the response of two other head surrogates, skin-skull-dura-brain, and skin-skull-dura-brain-falx-tentorium, was investigated. Head surrogate response was studied for sagittal and coronal plane rotations for impactor velocities of 1 and 3 m/s. Response of head surrogates was compared against strain measurements in PMHS. The strain pattern in the brain simulant was heterogenous, and peak strains were established within ∼30 ms. The choice of head surrogate affect the spatiotemporal evolution of strain. For no helmet case, peak MPS of ∼50–60% and peak MSS of ∼35–50% were seen in brain simulant corresponding to peak rotational accelerations of ∼5000–7000 rad/s2. Peak head kinematics and peak MPS have been reduced by up to 75% and 45%, respectively, with the conventional helmet and by up to 90% and 85%, respectively, with the helmet with antirotational pads. Overall, these results provide important, new data on brain simulant strains under a variety of loading scenarios—with and without the helmets.
Droplet Formation in Dynamic Stratified Liquid–Liquid Systems for Solution-Based Deposition Methods
Authors: Prussack Brett A. , Foradori Sean M. , Arnold Michael S. , Nellis Gregory F. , Berson Arganthael 
Published: July 2023

Abstract
The assembly of a two-dimensional (2D) nematic liquid crystal at an interface between two liquids can be exploited to assemble densely packed and highly aligned arrays of rod-like nanoparticles. This method is especially relevant to creating arrays of semiconducting carbon nanotubes (CNTs) for high-performance electronics. When a dense solvent containing CNTs flows over a less dense water subphase in a confined channel, the locally aligned arrays of nanoparticles align globally with the flow direction and can be transferred to the substrate. For large substrates and long channels, the dense solvent tends to slow and create a pool, which then drops through the interface and disturbs the delicate deposition process. Understanding this phenomenon is critical to improving and scaling up similar manufacturing processes. Here, data are collected, and an empirical model is developed to understand and predict the pooling behavior of a suspended fluid flowing over a less dense subphase. The model is demonstrated with two different solvents and proves to be accurate within +/− 15%. With a better understanding of the physics governing the system, the model is then used to suggest methods for minimizing pooling behavior.
Early Paleozoic crustal anatexis during Wuyi-Yunkai orogenesis: Insights from zircon of Fuhuling migmatites in the Yunkai region, South China
Authors: Zhang Junhao , Chen Zhen , Yakymchuk Chris , Sa Rina , Huang Qiangtai , Lou Feng , Tu Shuchen , Chen Tao 
Published: July 2023

AbstractCrustal anatexis is an important process in the tectonic evolution of many orogenic systems. In the Wuyi-Yunkai orogen in the South China block, the duration of partial melting and its relationship with orogenesis are poorly constrained. In this study, we present a multifaceted approach to determine the timing of anatexis and unravel the petrogenesis of Fuhuling migmatites in the Yunkai region of the southwestern South China block. Geochemical analyses indicate that the migmatites have (meta-)sedimentary protoliths. The absence of anhydrous peritectic minerals but the presence of microstructural and outcrop-scale indicators of partial melting suggest that the Fuhuling migmatites experienced fluid-present melting. Complex zoning and variable trace element concentrations in newly formed zircons in migmatites reflect their evolutionary histories during partial melting. Anatectic melt was present at Fuhuling in the Yunkai region from ca. 449–427 Ma during early Paleozoic Wuyi-Yunkai orogenesis. The wide variety of morphologies observed in the Fuhuling migmatites implies that migmatites in the Yunkai region experienced incipient partial melting, melt segregation, and melt migration. Combining new and previous results, we argue that the Yunkai region experienced two stages of crustal anatexis during the early Paleozoic, which may have been triggered by crustal thickening followed by rapid exhumation and orogenic collapse during the intra-plate Wuyi-Yunkai orogeny in the South China block.
Molecular Mechanisms of Tumor Cell Stemness Modulation during Formation of Spheroids
Authors: Ponomarev Aleksei S. , Gilazieva Zarema E. , Solovyova Valeriya V. , Rizvanov Albert A. 
Published: July 2023

Abstract
Cancer stem cells (CSCs), their properties and interaction with microenvironment are of interest in modern medicine and biology. There are many studies on the emergence of CSCs and their involvement in tumor pathogenesis. The most important property inherent to CSCs is their stemness. Stemness combines ability of the cell to maintain its pluripotency, give rise to differentiated cells, and interact with environment to maintain a balance between dormancy, proliferation, and regeneration. While adult stem cells exhibit these properties by participating in tissue homeostasis, CSCs behave as their malignant equivalents. High tumor resistance to therapy, ability to differentiate, activate angiogenesis and metastasis arise precisely due to the stemness of CSCs. These cells can be used as a target for therapy of different types of cancer. Laboratory models are needed to study cancer biology and find new therapeutic strategies. A promising direction is three-dimensional tumor models or spheroids. Such models exhibit properties resembling stemness in a natural tumor. By modifying spheroids, it becomes possible to investigate the effect of therapy on CSCs, thus contributing to the development of anti-tumor drug test systems. The review examines the niche of CSCs, the possibility of their study using three-dimensional spheroids, and existing markers for assessing stemness of CSCs.