bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hubungan Defisiensi Vitamin D dengan Keparahan Pemfigus Vulgaris
Authors: Chandra Rudi , Oentari Widyaningsih 
Published: April 2023

Latar Belakang: Pemfigus vulgaris (PV) merupakan penyakit bulosa autoimun kulit dan membran mukosa yang jarang, disebabkan oleh IgG-autoantibodi yang secara langsung menyerang desmoglein dan menyebabkan akantolisis. Rendahnya kadar vitamin D telah dikaitkan dengan keparahan penyakit pemfigus. Peran vitamin D pada perkembangan PV karena efek regulasi sistem imun dengan menekan fungsi sel Th1 dan menginduksi aktivitas sel Th2, sehingga meningkatkan sitokin yang berhubungan dengannya. Selain itu, vitamin D juga dapat meningkatkan populasi sel Treg yang berperan menekan sistem imun dan mencegah penyakit autoimun. Evidence-based case report ini bertujuan untuk mengetahui hubungan defisiensi vitamin D dengan keparahan penyakit PV. Metode: Penelusuran artikel dilakukan di Pubmed dan Cochrane berdasarkan pertanyaan klinis dan pemilihan artikel sesuai kriteria inklusi dan eksklusi. Artikel yang terpilih ditelaah kritis berdasarkan aspek validity, importance, dan applicability. Hasil: Didapatkan 1 artikel cross-sectional oleh Moravvej, et al, yang melaporkan defisiensi vitamin D berhubungan dengan PAAS kutaneus yang lebih tinggi (OR 1,36 (1,11-1,66); p<0,01) dan total PAAS kutaneus yang lebih tinggi (OR 1,24 (1,08-1,41); p<0,01). Studi ini dinyatakan sahih, penting, dan dapat diterapkan pada pasien kami. Simpulan: Defisiensi vitamin D berhubungan dengan keparahan PV.

Background: Pemphigus vulgaris (PV) is a rare autoimmune bullous disease of the skin and mucous membranes, caused by IgG-autoantibodies that directly attack desmoglein, causing acantholysis. Low vitamin D level has been associated with PV’s severity. The role of vitamin D in the development of PV is due to its regulatory effect on the immune system by suppressing Th1-cells function and inducing Th2-cell activity, thereby increasing the associated cytokines. Vitamin D can also increase the population of Treg-cells that play a role in suppressing the immune system and preventing autoimmune diseases. This evidence-based case report aims to determine the relationship of vitamin D deficiency with the severity of PV. Method: Relevant articles were searched through Pubmed and Cochrane based on clinical questions and selected according to inclusion and exclusion criteria. Selected articles were analyzed critically based on validity, importance, and applicability. Results: One cross-sectional article by Moravvej, et al, reported vitamin D deficiency was associated with higher cutaneous PAAS (OR 1.36 (1.11-1.66); p<0.01) and total cutaneous PAAS (OR 1.24 (1.08-1.41); p<0.01). This study was valid, important, and applicable to our patients. Conclusion: Vitamin D deficiency is associated with the severity of PV.
Cardiorespiratory Fitness and level of Perceived Stress in Exercising and Non-Exercising Physical Therapy Students: Single Centered Survey
Authors: Afzal Ayesha , Khan Sehar Mustafa , Atta Mohyudin Salwa , Rehman Iqra , Abideen Zain Ul , Shakeel Amal 
Published: April 2023

Objective: To assess cardiorespiratory fitness and perceived stress level and to measure the correlation between them in exercising and non-exercising physical therapy students. Methods: A Descriptive Cross-sectional study was conducted at Lahore Medical and Dental College for a duration of almost six months from April 2019 to October 2019. A total of 240 students from 1st year to final year LCPT students were enrolled in the study. The subjects were categorized into two groups on the basis of inclusion and exclusion criteria. Non-Probability Convenient sampling utilized as a sampling technique. Cardiorespiratory fitness was assessed by using the Modified Harvard Step test and the level of the Perceived Stress was measured by Perceived Stress Scale questionnaire. Data analyses were carried out using SPSS 22 and results were presented in the form of Mean and Standard deviation. Results: A significantly higher degree of cardiorespiratory fitness was found in Group A(exercising) compared to Group B(non-exercising) (p<0.05) and significantly lower level of perceived stress was found in Group A as compared to Group B (p<0.05). Bivariate analysis indicates a moderate, negative correlation between Physical fitness index (PFI) and Perceived stress (p<0.01; r= -o.65). Conclusion: The current study concluded that the Exercising group showed better cardiorespiratory fitness and lower perceived stress as compared to the Non-exercising group. Cardiorespiratory fitness and perceived stress showed a highly significant correlation, which is moderate in strength and inversely proportional. This means that as cardiorespiratory fitness increases, the level of perceived stress decreases.
SOBREVIVENTE DE VIOLÊNCIA SEXUAL: UM ESTUDO DE CASO
Authors: Da Silva Katyane Tabosa Mendes , Bushatsky Magaly , De Almeida Adriana Conrado , Soriano Evelyne Pessoa , Dourado Ana Cláudia Amorim Gomes , Lemos Isabella Maria da Silva , De Albuquerque Lucineide Bezerra , Spinelli Maria Flávia Gondim de Morais 
Published: April 2023

O presente artigo tem como objetivo abordar um estudo de caso de violência sexual contra uma mulher que ocorreu em uma zona rural de uma cidade no Agreste de Pernambuco, onde a sobrevivente gestacionou doze filhos do próprio pai. A violência doméstica contra a mulher é um fenômeno multifatorial. Trata-se de uma pesquisa descritiva com abordagem qualitativa, com uma vítima sobrevivente de abuso sexual na sua pessoa é acompanhada por instituição social. O projeto foi aprovado pelo comite de etica em pesquisa do HUOC/PROCAPE-UPE com CAAE nº 64963322.6.0000.5192, conforme resolução nº 466/12 CNS/MS . Este estudo ampliou a visibilidade sobre a necessidade de implementação de políticas públicas nas zonas rurais da localidade, considerando a necessidade de prevenção e combate a violência contra mulheres. Trata-sede uma temática delicada, de carater sigiloso nos processos de justiça; por este motivo, seu nome foi substituido por nome fictício no decorrer de todo artigo.
Anatomical and Functional Outcome of Retinal Detachment Surgery
Authors: Mishra Suraj Kumar , Chaudhary Aparajita , Singh Vinod , Singh SP 
Published: April 2023

Objective: To study the anatomical status and functional outcome of Pars Plana Vitrectomy surgery in rhegmatogenous retinal detachment (RRD) at a tertiary eye care center in India.
Material, Patients and Method: This is a prospective, noncomparative, consecutive, interventional study of rhegmatogenous retinal detachment managed with Pars Plana Vitrectomy surgery performed in the Regional Institute of Ophthalmology, Prayagraj, India. 40 patients of 40 eyes (26 phakic 65%, 14 pseudophakic 35%) with retinal detachment were treated by primary pars plana vitrectomy with 6 months of follow-up.
Result: A total of 40 patients (40 eyes) were operated, 18 males and 2 females, with age, ranges from 17 years to 90 years. After surgery, anatomically retinal reattachment was achieved in 40 (100%). Improved best-corrected visual acuity (BCVA) was seen in 38 (90%) patients, whereas in 2 (5%) patient BCVA was not improving and deteriorated from pre-operative in another 2 (5%) patient. There was no significant difference was found in the pseudophakic and phakic eye in functional outcome.
Conclusion: Rhegmatogenous retinal detachment is one of the common causes of visual impairment and blindness. Timely surgical management with Pars Plana Vitrectomy surgery can give good anatomical and visual outcome.
Risk Reduction
Authors: Richardson Varas Roberto 
Published: April 2023

The existing high alluvial risk Basin Lluta “Chile,” due to the presence of large mountains subject to inclement weather, coupled with the growing urban pressure to use sectors downstream increasingly exposed to this type of event, justify studies of the behavior of debris flows and the ability to mitigate its effects by the construction of protection and control. For this purpose, made the hidrogeomorfológica map for this basin. The surface of this basin is 3447 km2 and is in a desert area. It is characterized by low rainfall and therefore all its soils are devoid of vegetation except for the low part of the valley where the land use is agricultural. The natural regime has permanent basin runoff to the sea all year round with an average flow of 0.45–1.44 m3seg. The impact has increased the flow, but homogeneity is not presented with the full extent of the basin, showing notable spatial differences in the level of danger she originates. Different from what was described flood of 2001, which was reflected in the lower basin Lluta where road infrastructure was badly damaged by the effects of scouring and landslides, resulting in this reconstruction of road and railway bridges, implying a strong investment in works of river bank protection upstream of the bridges.
The Paradigm of Complex Probability and the Theory of Metarelativity: A Simplified Model of MCPP
Authors: Abou Jaoudé Abdo 
Published: April 2023

All our work in classical probability theory is to compute probabilities. The original idea in this research work is to add new dimensions to our random experiment, which will make the work deterministic. In fact, probability theory is a nondeterministic theory by nature; which means that the outcome of the events is due to chance and luck. By adding new dimensions to the event in the real set of probabilities R, we make the work deterministic, and hence a random experiment will have a certain outcome in the complex set of probabilities and total universe G = C. It is of great importance that the stochastic system, like in real-world problems, becomes totally predictable since we will be totally knowledgeable to foretell the outcome of chaotic and random events that occur in nature, for example, in statistical mechanics or in all stochastic processes. Therefore, the work that should be done is to add to the real set of probabilities R the contributions of M, which is the imaginary set of probabilities that will make the event in G = C=R+Mdeterministic. If this is found to be fruitful, then a new theory in statistical sciences and in science, in general, is elaborated and this is to understand absolutely deterministically those phenomena that used to be random phenomena in R. This paradigm was initiated and developed in my previous 21 publications. Moreover, this model will be related to my theory of Metarelativity, which takes into account faster-than-light matter and energy. This is what I called “The Metarelativistic Complex Probability Paradigm (MCPP),” which will be elaborated on in the present two chapters 1 and 2.
Wideband True Time Delay Cells
Authors: Yarahmadi Ahmad 
Published: April 2023

True-time delay (TTD) cells are used in timed array receivers for wideband multi-antenna topologies. TTD cells are divided into two major categories: silicon-based and non-silicon-based structures. Non-silicon-based structures have very good bandwidth but are bulky in the below 10 GHz frequency band. Silicon-based TTD cells are much more compact and better candidates for integrated circuit (IC) design. Passive and active approaches are the two ways to have a silicon-based TTD cell. Passive TTD cells are built by transmission lines (TL), artificial transmission lines (ATL), and LC ladder networks. Their power consumption is very low, and the delay bandwidth is good, but they are still bulky at low frequencies like below 5 GHz applications. Active all-pass filters as TTD cells are presented for these issues. In this chapter, we will discuss the challenges of inductor-based TTD cells. Then, inductor-less TTD cells are presented to address some of the previous structure’s issues. Finally, we will talk about these structures’ challenges as well. Then, the nonidealities effects on the TTD cell’s performance are investigated, and the body bias technique is presented to address these issues.
Em defesa de uma educação jurídica humanista para além de um ocasionalismo prático nos processos educativos
Authors: Palmeira Lana Lisiêr de Lima , Prado Edna Cristina , Santos Inalda Maria , Silva Givanildo 
Published: April 2023

Partindo-se da verificabilidade de que a formação propagada pelos cursos de Direito não favorecem uma preparação humanística sólida, já que seus currículos estão ainda muito arraigados aos ideais conservadores do positivismo clássico, objetivou-se no estudo em comento realizar uma análise em torno de como os currículos se originaram, buscando, para respaldar a análise, estabelecer como ponto de partida a tradição romana e sua arqueologia do saber jurídico, para, em seguida, adentrar nas reflexões em torno da ciência e da técnica na modernidade, desnudando aspectos valiosos a fim de se (re)pensar uma pauta humanista nessa seara. Como opção teórico-metodológica, adotou-se a abordagem de natureza qualitativa, com ênfase na revisão de literatura. Assim, após todas as questões apresentadas e, tomando por base pensadores como Paulo Freire, Walter Benjamin, Hannah Arendt, John Rawls, Jürgen Habermas, dentre outros, ficou evidente a necessidade concreta de um modelo de educação jurídica que possa romper com a configuração socioeducacional atual e que seja capaz de assegurar a junção equilibrada entre o Humanismo, a Ciência, a Técnica, as Artes e, sobretudo, que seja apto a minimizar os flagelos ainda gritantes na segunda década deste século.
Variety Types of Natural Food Fish Usage in The Growth of Super Red Arowana Fish (Scleropages Formosus)
Authors: Panjaitan Amyda Suryati , Hapsari Fitriska , Margono Margono , Al-Qoyyimah Himmah 
Published: April 2023

This study aims to determine the effect of giving several types of natural feed and evaluate the best type of feed for thebody length of super red arowana fish (Scleropages formosus). This study used the Complete Randomized Design (RAL) method with 3 treatments and 3 repeats with 3 types of natural feed, namely crickets (A), Hong Kong caterpillars (B), and white shrimp (C). The maintenance of super red arowana fish is carried out for 70 days with a frequency of feeding three times a day and given satiation (ad satiation). The results showed that the feeding of crickets for super red arowana fish gave the highest length of 0.84±0.08 cm, the highest specific growth rate of 6.00±0.59%, and the survival rate (SR) at the end of the study was 100%. The results of measuring water quality parameters, namely temperatures of 28.7° C -30.4 °C, pH 7.97-8.14, and dissolved oxygen 4.6-5.4 mg.l⁻¹, are in the optimal range for the maintenance of super red arowana fish.
Total remission of Merkel cell carcinoma after Coronavirus infection: a case report
Authors: Vidoto Lucas Henrique Rigon , Martins Cicero Luiz Cunha , De Melo Andreia Cristina 
Published: April 2023

ABSTRACTA 65-years old Peruvian woman was admitted to the Brazilian National Cancer Institute, with a diagnosis of Merkel cell carcinoma in the left shoulder. A PET-CT confirmed the locally advanced disease, with the involvement of lymph nodes in the axillary region. At the time of the proposed surgical procedure, the patient tested positive for COVID-19 without symptoms. She returned for an appointment one month later recovering from COVID-19, reporting a significant decrease in the lesion. One month later, no lesion was clinically found on the left shoulder. Due to the possible remission of the disease, a new PET CT was requested, revealing no metabolic findings suggestive of active neoplastic tissue.
Na rua, no hospital, por debaixo da máscara: palhaçaria como potência transformadora
Authors: Silva Vitoria Carine da 
Published: April 2023

O presente artigo traz relatos de experiências vividas no hospital a partir do olhar de uma palhaça que inicia sua trajetória na rua, vai para a Universidade, passa pela docência e hoje pesquisa em um hospital. A partir dos relatos - chamados de relatórios bobológicos – fez-se uma reflexão sobre a potência transformadora da palhaçaria enquanto ferramenta de subversão, seja qual for o ambiente escolhido de atuação. O primeiro relatório bobológico é da primeira visita ao hospital, visita de “cara limpa” (sem estar de palhaça), e os dois últimos relatórios são após quase um ano de atuação.
Redução da subjetividade na classificação de criticidade de versão de software com o apoio de sistema especialista
Authors: Gatto Dacyr Dante de Oliveira , Evangelista João Rafael Gonçalves , Leonardis Roger Willian Joel , Sassi Renato José 
Published: April 2023

Na execução de um processo de gerenciamento de liberação de versão de software existe a necessidade por parte dos especialistas humanos executores do processo de classificar a criticidade de cada versão de software. No entanto, a subjetividade desta classificação pode estar presente em função da experiência adquirida pelos especialistas ao longo dos anos. Com o objetivo de reduzir a subjetividade no processo, pode-se aplicar uma técnica de Inteligência Artificial denominada de Sistema Especialista (SE) para representar o conhecimento de especialistas humanos e utilizá-lo na resolução de problemas. Assim, o objetivo deste trabalho foi reduzir a subjetividade na classificação de criticidade de versão de software com o apoio de Sistema Especialista. Para tanto, elaborou-se um questionário com o objetivo de obter os pareceres de criticidade classificados em Alta, Média e Baixa de versão de software de cada especialista para auxiliar na elaboração das regras de produção do SE. O SE gerou 17 regras de produção com grau de confiança de 100% aplicadas em uma base de dados de produção. Os resultados da classificação realizada pelo SE corresponderam à classificação realizada pelos especialistas na base de produção, ou seja, o SE conseguiu representar o conhecimento deles. Em seguida, aplicou-se outro questionário aos especialistas a fim de verificar a percepção sobre a satisfação em relação ao uso do SE com resultado obtido de 4,8, considerado satisfatório . Concluiu-se, então, que o SE apoiou na redução da subjetividade na classificação da criticidade de versão de software.
Floristic Composition and Species Diversity of Wintering Herbs in Blue pine Forest of Thimphu District, Bhutan
Authors: Tshering Chungdu , Wangmo Tshering 
Published: April 2023

Aims: This study was carried out to document wintering herbs species in the blue pine (Pinus wallichiana) forest of Kawang Gewog under Thimphu district, Bhutan. To generate baseline data on species diversity and composition of the winter herbaceous layer in the blue pine forests of the study area.
Study Design: To evaluate the floral diversity and composition of herbs, stratified random sampling was used.
Place and Duration of Study: The study was conducted in Thimphu district within the altitudinal range of 2400 m to 2700 m A.S.L. The fieldwork was conducted during the month of December to January 2019 and during March 2020.
Methodology: Four line transects were established randomly, with sampling points placed at 25-meter intervals along the transect. For adequate data collection, three 3X3 meter quadrats were laid along a straight line perpendicular to the transect, using species-area Type I curves (strictly nested curves). Each quadrat was then divided into 100 equal sub-quadrats, with a distance of 5 meters separating each quadrat.
Results: A total of 60 herb species belonging to 46 genera and 22 families. The Shannon-wiener index of species diversity (H’) showed 1.73 value suggesting higher diversity in the study site with an altitude of 2600 m to 2700 m compared to other sites with an altitude range of 2400 m to 2500 m, H’ value of 1.59.
Conclusion: The study conducted reports the finding on diversity and the composition of herbs occurring in the winter season from Kawang Gewog under Thimphu district. The present study also discusses the diversity and evenness of herbs influenced by elevation and anthropogenic influences.
Screening of Antimicrobial Activity of Poly Herbal Extracts against Bacterial Pathogens Causing Gastroenteritis in Tharaka Nithi County, Kenya
Authors: Kiteme Mbithe P. , Onyango Benson O. , Njagi Eric C. , Ogolla Fredrick O. 
Published: April 2023

Herbals have been used for decades to treat gastrointestinal infections across the world, including in Tharaka-Nithi County, Kenya. Crude extracts from herbs have long been prescribed by traditional healers for treatment of typhoid, cholera, and shigellosis. However, the effectiveness of extracts obtained using different extraction solvents such as methanol, acetone, and hexane have not fully been evaluated. This study aimed at evaluating the effect of solvents (Ethanol, hexane, and methanol) on the yield of crude extract from plants (Erythrinna abyssinica, Aspilia pluriseta, Vangueria infausta, Ficus sycomorus, and Carissa edulis), assessing the effect of the solvents on extracted active metabolites, and determining the effect of these solvents on extract’s bioactivity against Vibrio cholerae, Shigella flexneri, and Salmonella typhimuriumi and, Escherichia coli that served as a model organism for screening plant extracts against Gram-negative bacteria. Crude extracts were obtained by soaking dried ground plant parts in individual solvents, which were then concentrated by a rotary evaporator. The phytochemical screening to detect plant metabolites was done qualitatively. Bioassays to analyze the efficacy of the plant crude extracts against the microbes were carried out in 4×3×3×5 factorial experiment laid out in a completely randomized design. The determination of bioactivity of herbal extracts was carried out using minimal inhibition concentration and minimum bactericidal concentration methods. Data obtained on the bioactivity assay (Count of the bacteria colony forming units) was analyzed using the Kruskal-Wallis test at α = 0.05, and medians were compared by the Wilcoxon rank sum test in Scientific Analysis System version 9.4. Methanol solvent produced higher quantities of crude extracts for all the herbal samples used with, Vangueria infausta producing the highest extract (5.06g). Most phytochemicals were present in Methanolic extracts compared to hexane and acetone extracts. There was a significant (p < 0.05) difference in the bioactivity of different herbal plants against bacterial pathogens at different concentrations of crude extract. The efficacy of plant extract increased progressively from 100ppm to 1000ppm concentration. Methanol is recommended for use in the extraction of medicinal plant extracts as it leads to improved potency as compared to hexane and acetone.