bluuebunny/crossref_metadata_2025_split huggingface dataset:
Imaging of Atherosclerosis with [64Cu]Cu-DOTA-TATE: a Translational Head-to-Head Comparison Study with 2-[18F]FDG, and Na[18F]F in Rabbits
Authors: Grandjean Constance E. , Pedersen Sune F. , Christensen Camilla , Dibenedetto Altea , Eriksen Thomas , Binderup Tina , Kjaer Andreas 
Published: December 2022

Abstract
Atherosclerosis is a chronic inflammatory disease of the larger arteries that may lead to cardiovascular events. Identification of patients at highest risk of cardiovascular events is challenging, but molecular imaging using positron emission tomography (PET) may prove useful.
The aim of this study was to evaluate and compare head-to-head three different PET tracers. Furthermore, tracer uptake is compared to gene expression alterations of the arterial vessel wall.
Methods
Male New Zealand White rabbits (control group; n=10, atherosclerotic group; n=11) were used for the study. Vessel wall uptake was assessed with the three different PET tracers: 2-[18F]FDG (inflammation), Na[18F]F (microcalcification), and [64Cu]Cu-DOTA-TATE (macrophages), using PET/Computed Tomography (CT). Tracer uptake was measured as standardized uptake value (SUV), and arteries from both groups were analyzed ex vivo by autoradiography, qPCR, histology, and immunohistochemistry.
Results
In rabbits, the atherosclerotic group showed significantly higher uptake of all three tracers compared to the control group 2-[18F]FDG: SUVmean 1.50 ± 0.11 vs. 1.23 ± 0.09, p = 0.025; Na[18F]F: SUVmean 1.54 ± 0.06 vs. 1.18 ± 0.10, p = 0.006; and [64Cu]Cu-DOTA-TATE: SUVmean 2.30 ± 0.27 vs. 1.65 ± 0.16; p = 0.047. Of the 102 genes analyzed, 52 were differentially expressed in the atherosclerotic group compared to the control group and several genes correlated with tracer uptake.
Conclusion
In conclusion, we demonstrated the diagnostic value of [64Cu]Cu-DOTA-TATE and Na[18F]F for identifying atherosclerosis in rabbits. The two PET tracers provided information that could not be obtained with 2-[18F]FDG.
Research on wheel-legged robot based on LQR and ADRC
Authors: Liu Shuaishuai , Yuan Qiang , Wang Bangyu , Xiao Junbo , Zhao Daxu 
Published: December 2022

Abstract
The traditional two-wheeled self-balancing robot can travel quickly in a flat road environment, and it is easy to destabilize andcapsize when passing through a bumpy road. To improve the passing ability of a two-wheeled robot, a new wheel-leggedtwo-wheeled robot is developed. A seven-link leg structure is proposed through the comprehensive design of mechanismconfiguration, which decouples the balanced motion and leg motion of the robot. Based on the Euler-Lagrange method, thedynamic model of the system is obtained by applying the nonholonomic dynamic Routh equation in the generalized coordinatesystem. The robot’s state space is divided according to the robot’s height, and the Riccati equation is solved in real-time by thelinear quadratic regulator(LQR) method to complete the balance and motion control of the robot. The robot leg motion controlis achieved based on the Active Disturbance Rejection Control(ADRC) way. A robot simulation model is built on Recurdyn toverify the algorithm’s feasibility, and then an experimental prototype is built to demonstrate the algorithm’s effectiveness. Theexperimental results show that the control method based on LQR and ADRC can make the robot pass through the bumpy road.
Stoma Acceptance and Its Related Factors Among Colorectal Cancer Patients：A Descriptive Study
Authors: Jing Xuebing , Han Qingkun , Han Wei , Gao Tingting , Li Cuiping , Wei Jingwen , Yang Xiaoping 
Published: December 2022

Abstract
Purpose: The aim of the study is to determine the levels and related factors of colorectal cancer patients about stoma acceptance.
Methods: This descriptive study enrolled 136 colorectal cancer outpatients follow-up at several hospitals in Shandong province. Stoma acceptance was assessed with Chinese version stoma acceptance questionnaire(SAQ). The association of stoma acceptance and colorectal cancer patients characteristics was assessed by logistic regression.
Results: The total average stoma acceptance of 136 patients in this study was(37.03±4.87). General self-efficacy was(27.96±5.28). General self-efficacy was positively associated with stoma acceptance(r=0.529，P<0.001). The linear regression results showed that factors of general self-efficacy, social needs, receiving medical follow-up and education level were the factors affecting stoma acceptance in colorectal cancer patients.
Conclusions: The stoma acceptance in colorectal cancer patients in grade 3 hospitals is at a medium level in China. Medical staff should pay attention to it, and improve caregiver’ supports, increase medical follow-up,meet the need for social communication. Strengthen the intervention of patients’ self-efficacy to intervene, so as to improve the stoma acceptance and improve the quality of life.
The Long-term impact of Covid-19 on student mental health
Authors: Catling Jon C. 
Published: December 2022

Abstract
Background
The COVID-19 pandemic and the resulting restrictions placed upon society have had a profound impact on both physical and mental health, particularly for young people.
Aims
The current study assesses student mental health pre, within and post COVID.
Method
Eight hundred and fourteen first year Undergraduate students completed a battery of self-report questionnaires to assess for depression, mobile phone use, self-esteem, resilience and social support with data being collected over a three year period. The data from each year was compared (216, 218 and 380 students respectively).
Results
A MANOVA revealed that COVID-19 had a significant impact on self-reported levels of depression, smartphone use, Self-esteem, resilience and social support. Multiple regression analysis revealed that Smart phone use and resilience were significant predictors of levels of depression.
Conclusions
This research suggests that COVID-19 has had a major impact upon student mental health, and that we have not yet seen a recovery in our ‘post-Covid’ times.
Comparison of Insulin Resistance and Overian Volume in Patients with Polycystic Ovary Syndrome with and without Hashimoto
Authors: Gencer Gülcan , Serin Aliye Nigar , Gencer Kerem 
Published: December 2022

Abstract
Objective: In this study, our aim was to divide the patients diagnosed with polycystic ovary syndrome (PCOS) and Hashimoto's thyroiditis (HT) into subgroups according to different clinical and laboratory findings. It is to investigate whether it will exacerbate it.
Material and Methods: 46 PCOS patients and 46 PCOS patients diagnosed with HT were included in this study. A detailed medical history was taken from all participants. Polycystic ovary image was evaluated as below or above 10 ml and antral follicles were counted by transvaginal ultrasound. Insulin resistance of the patients was evaluated according to the fasting insulin (HOMA) index.
Results: Insulin resistance was found to be associated with fasting insulin, HOMA index, body mass index and right ovarian volume in patients diagnosed with PCOS. Among the patients diagnosed with PCOS+HT, insulin resistance was found to be significantly correlated with fasting insulin, HOMA index, (BMI), (SHBG) and left ovarian volume. An increase in right ovarian volume was found in 37.5% of patients with PCOS without insulin resistance and in 76.3% of patients with insulin resistance. An increase in left ovarian volume was found in 35.7% of patients without insulin resistance diagnosed with PCOS+HT and in 68.8% of patients with insulin resistance.
Conclusions: This study shows that in order to predict insulin resistance that causes long-term metabolic diseases, ovarian volume should be evaluated in every PCOS patient and all PCOS patients with increased ovarian volume should be investigated for insulin resistance. In addition, it has been observed that insulin resistance affects left ovarian volume in patients with PCOS+HT, while insulin resistance affects the volume of the right ovary more in patients with PCOS. At least one ovary has been found to be affected by long-term metabolic diseases.
Prevalence and Risk Factors of Bovine Tuberculosis in Cattle in Selected Districts of Fafan Zone, Eastern Ethiopia
Authors: Hussein Hassan Abdi , Musse Abdi Hussein 
Published: December 2022

Abstract
Cross-sectional study was conducted from October 2021 to August 2022, to investigate the prevalence and associated risk factors of bovine tuberculosis in cattle in selected districts of Fafan zone. The prevalence was 11.24% (95% CI, 8.61–14.35) and 43.3% (95% CI, 33.27–53.75) at individual and herd level respectively. There were statistically significant differences in proportions of positive reactor animals among body condition score (χ2 = 47.9, P = 0.000), Age (χ2 = 6.0937, P = 0.048), Seasonal migration (χ2 = 4.320, P = 0.038), parity number (χ2 = 10.62, P = 0.005), reproductive status (χ2 = 4.36, P = 0.037). Multivariable logistic regression analysis showed that animal with poor body condition score was more likely to react positive than those in good body condition score adjusted (OR = 0.163; CI = 0.0679 -0.390). Moreover, seasonally migrating cattle had 2.787 times the odds of being tuberculin reactors compared with those non migrating cattle (adjusted OR = 2.787; CI = 1.221–6.358). According to questionnaire, 14.2% (17 of 120) and 13.3% (16 of 120) of the respondents were knowledgeable about bovine tuberculosis and its transmission from animal to human and vice versa, respectively. The general judgment of herders' understanding of BTB transmission methods to humans was very low. This finding provides relatively high prevalence of BTB in cattle at the study area and highlights the need for a practicable control strategy of the disease in the region.
Sex difference in the cytokine profile among patients hospitalized for COVID-19 and during their recovery: predominance of females in adhesion molecules and males in oxidative stress
Authors: Mitrović-Ajtić Olivera , Djikić Dragoslava , Subotički Tijana , Bižić-Radulović Sandra , Beleslin-Čokić Bojana , Dragojević Teodora , Živković Emilija , Miljatović Sanja , Čokić Vladan 
Published: December 2022

Abstract
Background
Male sex is associated with greater severity and mortality from coronavirus disease 2019 (COVID-19), although infections are equally distributed between men and women. The present study aims to investigate sex differences in the hyperinflammatory immune response to SARS-CoV-2 infection and consequent thrombosis using linked cytokine profile and blood laboratory data.
Methods
This observational cohort study involved 99 COVID-19 patients (69 male and 30 female adults), hospitalized between March 2021 and April 2022. Their clinical and laboratory data were collected to examine sex difference in oxidative stress, neutrophil extracellular traps (NETs) formation and plasma cytokines at hospital admission and up to 5 months of their recovery.
Results
Dihydrotestosterone (DHT) levels were transiently reduced, while sex hormone binding globulin levels were continuously decreased in male post-COVID-19 patients after its rise at diagnosis. Regarding inflammatory cytokines, interleukin-6 (IL-6) and interferon-gamma are generally increased at diagnosis, while IL-6 is decreasing in post-COVID-19 patients. Tumor necrosis factor-alpha had 5-fold increase in females at diagnosis. Chemokines IL-8 and monocyte chemoattractant protein-1 and coagulation markers intercellular adhesion molecule-1 and E-selectin were consistently upregulated in female COVID-19 and post-COVID-19 patients, in contrast to vascular cell adhesion molecule-1 and P-selectin. DHT increased reactive oxygen species in neutrophils of male patients, while estrogen decreased in females. Markers for NETs formation, such as circulating DNA and myeloperoxidase, were significantly increased in the plasma of patients. Sex hormones are mostly negatively correlated with leukocytes, while in positive correlation with coagulation markers.
Conclusions
Markers of chemotaxis, endothelial dysfunction and inflammation are still detectable and partially sex dependent in COVID-19 patients after 5 months of hospital admission. These distributions of sex steroid hormones splitted endothelial adhesion molecules, coagulation and inflammation factors, while they generalized chemokines.
Wnt Signaling Pathway Related Gene CTNNBIP1 Act as A potential Prognostic Biomarker and A Comprehensive Prognostic Analysis in Osteosarcoma
Authors: Wen Jian , WAN Lijia , Dong Xieping 
Published: December 2022

Abstract
Purpose
Osteosarcoma is the most common primary bone malignancy in children and young adults with poor outcomes in patients with recurrence and metastasis. The role of Wnt signaling pathway in osteosarcoma was complex and not well specified.
Methods
KEGG Wnt signaling pathway related genes were screened by univariate Cox regression analysis, Boruta feature selection and KM analysis in TARGET-OS cohort for the gene with the highest prognostic value in osteosarcoma. Clinical and immune cell infiltration features were also screened by univariate Cox regression, respectively. A prognostic model was established by the indicators screened above and evaluated in training and validation sets. Then, functional analysis of the differentially expressed genes were performed.
Results
CTNNBIP1 was screened as the KEGG Wnt signaling pathway related gene with the highest prognostic value in osteosarcoma. Metastasis, tumor site and M2 macrophage infiltration in tumor tissue were also identified as prognostic indicators. The model established by these indicators was evaluated in training set and successfully validated in validation set. C-index (0.812 in training set and 0.787 in validation set) and Calibration analysis suggested that the model had high prediction accuracy both in training and validation set. AUCs of the ROC analysis for 1-,3-,5-year prediction of the model were 0.96, 0.81 and 0.81 in training set, 0.80, 0.83 and 0.89 in validation set. Decision curve analyses also showed that patients could get high net benefit from the model. Functional analyses of the differential expressed genes between normal and osteosarcoma patients indicated that Wnt signaling pathway and cell cycle were upregulated and focal adhesion was downregulated in osteosarcoma patients. The overexpression of CTNNBIP1 in osteosarcoma tissues was validated by immunohistochemistry.
Conclusions
CTNNBIP1 was a potential prognostic gene and therapeutic target in osteosarcoma. Prognostic model established by CTNNBIP1, clinical and immune cell infiltration indicators had good prediction accuracy and discriminatory capacity.
A Neonate with Multiple Hand Flexor Tendon Ruptures due to Methicillin-susceptible Staphylococcus aureusSepsis: A Case Report
Authors: Nakamura Tomomi , Iwai Masanori , Inoue Takeshi , Irie Hiroki , Karasugi Tatsuki , Seki Atsuhito , Hamaguchi Masayoshi , Kuraoka Shohei , Mizukami Tomoyuki , Nakamura Kimitoshi 
Published: December 2022

Abstract

Background: Neonatal pyogenic tenosynovitis is a highly emergent soft tissue infection. We report a case of a neonate with pyogenic tendinopathy and tendon rupture diagnosed by ultrasonography (US). He subsequently developed pyogenic arthritis and osteomyelitis during antimicrobial therapy.Case presentation: A 7-day-old boy was admitted to our hospital with redness and swelling of the right index finger. US on admission showed rupture of the flexor tendon of the right index finger with inactivity. The day after admission, he developed pyogenic arthritis of the right elbow and, subsequently, pyogenic osteomyelitis.Staphylococcus aureuswas identified through bacterial culture, and the patient was treated with intravenous antibiotics for 6 weeks. However, after discharge from our hospital, rupture of the flexor tendon of the left thumb was confirmed. A two-stage flexor tendinoplasty was completed at the age of 2 years and 1 month for the flexor tendon rupture on his right index finger.Conclusions: In addition to blood culture, ultrasonographic evaluation should be performed in neonates with erythematous and swollen joints to identify the focus of infection as soon as possible. Moreover, repeated regular US examination is important in the follow-up of bone and soft tissue infections.
Multifocal brain abscess caused by Aspergillus fumigatus infection in patients with Heat Stroke: a case report
Authors: Ding Peng , Zhou Yuan , Wang Chunxia , Zhou Xiujuan , Long Kunlan , Gao Peiyang 
Published: December 2022

Abstract
Background:
Aspergillus fumigatus is a filamentous fungus widely distributed in the environment and can cause life-threatening diseases in individuals with compromised immune barriers. To our knowledge, it has never been reported as a cause of intracranial infection in patients with heat stroke. We report a case of heat stroke patient with multifocal brain abscess caused by aspergillus fumigatus infection.
Case presentation:
A 48-year-old male patient was admitted to the intensive care unit due to fever and loss of consciousness. The patient was diagnosed with heat stroke because he worked in a high-temperature environment, had a hospital temperature of 42℃, had liver, kidney and heart damage, and had disseminated intravascular coagulation. Although the patient was actively rescued, the patient was still coma and fever. Head Computed tomography (CT) and magnetic resonance imaging ( MRI ) showed abnormal signal lesions in bilateral basal ganglia, right temporal lobe, left frontal lobe and left cerebellar hemisphere. Serum galactomannan increased. It was identified as Aspergillus fumigatus by next generation sequencing ( NGS ) using cerebrospinal fluid. The patient received 4 weeks of voriconazole treatment. Reexamination of head CT suggested that the range of low-density lesions in the above brain regions was reduced. Then the patient gradually woke up, could follow the instructions of exercise, and finally discharged.
Conclusion:
Heat stroke combined with multifocal brain abscess caused by aspergillus fumigatus infection is extremely rare. For patients who still have central nervous system symptoms and signs after conventional treatment, the possibility of intracranial infection needs to be considered.
A qualitative exploration of food portion size practices and awareness of food portion size guidance in first-time parents of one- to two-year-olds living in the UK
Authors: Porter Alice , Langford Rebecca , Summerbell Carolyn , Tinner Laura , Kipping Ruth 
Published: December 2022

Abstract
Background
Food portion size guidance resources aimed at parents of young children in the UK are freely available from a number of credible sources. However, little is known about whether parents are aware of, and use, any of these resources to guide their food portioning practices.
Objectives
We aimed to explore the food portion size practices used by first-time parents living in the UK when feeding their one- to two-year-old child, and also their awareness of and views on six food portion size guidance resources.
Methods
Participants were recruited via parent Facebook groups and online parent forums. Online 1-1 semi-structured interviews were conducted, during which parents were shown images of six food portion sizeguidance resources to facilitate discussion. Data was analysed in NVivo 11 using a Reflexive Thematic Analysis approach.
Results
Of the 27 participants, most were women (n=25), white (n=18), and educated to a first degree level or higher (n=24). First-time parents mostly relied on their own judgement and “instinct” to portion foods, based on their learned experience of how much their child ate on a day-to-day basis. This experience was used alongside physical indicators of food portion size, such as the size of children’s dishware and food packaging. Most participants were unaware of any of the six food portion size guidance resources we showed them; only four had read any of the resources. Parents suggested they had previously sought advice about weaning from a range of sources (e.g. online, friends, community groups) but would be unlikely to seek out specific food portion size guidance. Parents suggested recommendations on food portion size should acknowledge and highlight parents’ perception that “every child is different”.
Conclusions
Existing food portion size guidance resources for parents of young children in the UK are ineffective as they have poor reach and impact. We suggest parents should be involved in developing novel strategies to promote age-appropriate consumption and healthy weight gain in young children.
Malaria Vaccine Impact on Cases, Drug-resistant Cases, and Deaths in Africa: A Modeling Study
Authors: Hamilton Alisa , Haghpanah Fardad , Hasso-Agopsowicz Mateusz , Frost Isabel , Lin Gary , Schueller Emily , Klein Eili , Laxminarayan Ramanan 
Published: December 2022

Abstract
Background
The emergence of antimalarial drug resistance poses a major threat to effective malaria treatment and control in sub-Saharan Africa. The RTS, S/AS01 vaccine has the potential to reduce both resistant infections and antimalarial use. Modeling studies projecting aggregate health burden averted under different scenarios can support further vaccine development and implementation.
Methods
A mathematical model projecting cases, drug-resistant cases, and deaths averted from 2021 to 2030 with a vaccine against clinical malaria caused by Plasmodium falciparum administered yearly to one-year-olds in the WHO Africa Region.
Findings
Under a scenario in which vaccine efficacy (VE) was constant at 40% for four years and dropped to 0% in year five, approximately 92.5 million cases, 700,000 resistant cases, and 253,000 deaths were averted by 2030. In a scenario in which VE began at 80% and dropped 20 percentage points each year, approximately 123 million cases, one million resistant cases, and 336,000 deaths were averted. The highest burden averted occurred when VE remained 40% for 10 years with approximately 151 million cases, 1.1 million resistant cases, and 411,000 deaths averted. In a scenario of rapidly increasing drug resistance and an effective vaccine, over 4.5 million resistant cases were averted.
Interpretation
Swift and widespread deployment of an effective malaria vaccine in Africa, alongside other prevention and control interventions, could substantially reduce health and economic burden caused by drug-resistant malaria.
Funding
This work was funded by a grant from the Bill & Melinda Gates Foundation (OPP1190803) to the Center for Disease Dynamics, Economics & Policy under the ARVac Consortium.