bluuebunny/crossref_metadata_2025_split huggingface dataset:
PPAR-gamma agonist pioglitazone recovers mitochondrial quality control in fibroblasts from PITRM1-deficient patients
Authors: Di Donfrancesco Alessia , Berlingieri Christian , Giacomello Marta , Frascarelli Chiara , Magalhaes Rebelo Ana Paula , Bindoff Laurence A. , Reeval Segel , Renbaum Paul , Santorelli Filippo M. , Massaro Giulia , Viscomi Carlo , Zeviani Massimo , Ghezzi Daniele , Bottani Emanuela , Brunetti Dario 
Published: July 2023

Introduction: Biallelic variants in PITRM1 are associated with a slowly progressive syndrome characterized by intellectual disability, spinocerebellar ataxia, cognitive decline and psychosis. The pitrilysin metallopeptidase 1 (PITRM1) is a mitochondrial matrix enzyme, which digests diverse oligopeptides, including the mitochondrial targeting sequences (MTS) that are cleaved from proteins imported across the inner mitochondrial membrane by the mitochondrial processing peptidase (MPP). Mitochondrial peptidases also play a role in the maturation of Frataxin, the protein affected in Friedreich’s ataxia. Recent studies in yeast indicated that the mitochondrial matrix protease Ste23, which is a homologue of the human insulin-degrading enzyme (IDE), cooperates with Cym1 (homologue of PITRM1) to ensure the proper functioning of the preprotein processing machinery. In humans, IDE could be upregulated by Peroxisome Proliferator-Activated Receptor Gamma (PPARG) agonists.Methods: We investigated preprotein processing, mitochondrial membrane potential and MTS degradation in control and patients’, and we evaluated the pharmacological effect of the PPARG agonist Pioglitazone on mitochondrial proteostasis.Results: We discovered that PITRM1 dysfunction results in the accumulation of MTS, leading to the disruption and dissipation of the mitochondrial membrane potential. This triggers a feedback inhibition of MPP activity, consequently impairing the processing and maturation of Frataxin. Furthermore, we found that the pharmacological stimulation of PPARG by Pioglitazone upregulates IDE and also PITRM1 protein levels restoring the presequence processing machinery and improving Frataxin maturation and mitochondrial function.Discussion: Our findings provide mechanistic insights and suggest a potential pharmacological strategy for this rare neurodegenerative mitochondrial disease.
A switchable terahertz metamaterial absorber between ultra-broadband and dual bands
Authors: Ren Zhi , Wang Wanqing , Zhao Yinghui , Chang Siqi , Ren Guanhua , Li Songtao , Wang Ruoxing 
Published: July 2023

Based on the phase change properties of vanadium dioxide (VO2), we propose a terahertz metamaterial absorber that can be switched flexibly between ultra-broadband and dual bands. The absorber consists of a resonator array above a conductive ground layer separated with a dielectric spacer, which includes four square-loop VO2 resonators and a crossed gold resonator in each unit cell. By changing the conductivity of VO2 through thermal control, the absorber can achieve the switching between ultra-broadband absorption and dual-band absorption. Simulation results show that at high temperature, the absorber realizes more than 90% absorption bandwidth in the range of 3.98 to 9.06 THz, which can be elucidated by the wave-interference theory and impedance matching theory. At low temperature, up to 95% of the dual-band absorption occurs at 5.95 and 6.95 THz, which originates the dipole mode and nonlocal surface-Bloch mode of metal resonators. In addition, the absorber has the advantages of polarization-independence and wide-angle absorption. Compared with previous studies, our design can switch between two absorption modes and its absorption performance is greatly improved. The proposed absorber design scheme is expected to expand terahertz devices and enable a variety of applications in the terahertz range, such as modulation, sensing, stealth, and switching devices.
The challenge of screen mediated shared reading for children’s learning and engagement
Authors: Read Kirsten , Harrison Hayley , Mireku Brianna , Ying Katrina 
Published: July 2023

IntroductionScreen mediated shared reading (SMSR), which involves an adult reading a child a book through video-chat, is a recent development in shared reading. In this study, we investigated whether, as in in-person shared reading, children could learn new words from SMSR, and whether having a physical copy of the book to follow along with impacted children’s novel word retention and engagement in this setting.MethodThree- to 5-year-old participants (n = 34) were read an 8-page rhyming, “Meet the Friendly Monsters” story by a researcher over Zoom, via screen sharing an e-version of the story used in previous studies. Participants were randomly assigned to one of two conditions: SMSR with or without a paper copy of the book to follow along with. The session was recorded to measure children’s engagement behaviors during the reading. Novel word learning from the story was measured with both a multiple choice identification test and a monster naming test, both administered immediately after the initial reading, then re-administered 10–14 days later. Engagement during the SMSR sessions was measured every 30-s on a scale of 1 (low engagement) to 5 (high engagement), and then averaged for each child.ResultsResults show that children overall performed slightly above chance on novel monster name retention from the SMSR. However, retention was not as strong as seen in other in-person shared reading studies using the same story. Additionally, while children remembered monster names with equal efficacy regardless of condition and level of engagement, there were still qualitative differences in the reading sessions depending on whether children had their own paper copy of the book to follow along with – in general, the ‘with book’ condition appeared to increase the challenges posed to children’s attention during SMSR, potentially making the word learning task more difficult.DiscussionThe findings of this study have implications for how to approach shared reading with young children in new contexts with the use of emerging technology. We raise future research questions for a better understanding of best practices for screen mediated shared reading.
Global research trends and prospects on the first-generation college students from 2002 to 2022: a bibliometric analysis via CiteSpace
Authors: Fei Li , Kang Xizhen , Sun Weiming , Hu Boxiang 
Published: July 2023

ObjectivesTo review literature related to first-generation college students, the paper aims to outline the research direction, identify prominent research topics and frontiers, report on current research trends, and offer valuable insights and fresh perspectives for future advancements in the field, utilizing CiteSpace.MethodsCiteSpace is a citation visualization software designed to analyze the scholarly literature and uncover potential knowledge within it. This study retrieved articles related to first-generation college students from 2002 to 2022 from Web of Science Core Collection database. After collecting the data, CiteSpace V.6.1.R3 (64-bit) was used to perform analyses on various aspects, including annual publication output, top cited journals, country and institutional affiliations, prominent authors, cited references, and keywords. The data was visualized using tools such as knowledge maps, collaborative network analysis, cluster analysis, and strongest citation burst analysis.ResultsWe obtained a total of 471 articles on first-generation college students. The number of publications annually is increasing, and the number of publications generally shows an upward trend, especially in 2017–2021 with a sharp growth. The United States has the most articles on this topic (395 articles), and it is also the most authoritative and influential country (with a centrality of 0.93). Followed by South Africa (14 articles) and Germany (14 articles), The top 10 cited journals and institutions are predominantly from the United States. When analyzing the top cited references and authors, the research consistently highlights the academic achievement and engagement of first-generation college students.ConclusionThis study analyzed the current situation of first-generation college students field via CiteSpace, then identify the research hotspots and frontiers on first-generation college students. Current global trends in first-generation college students researches and the growing public awareness of academic performance and equality suggest that first-generation college students researches will grow in popularity with further breakthroughs.
Humanistic care relieves mental distress of inpatients in the shelter hospital during COVID-19 pandemic in Shanghai: a cross-sectional observational study
Authors: Xiao Dongdong , Huang Hua , Chen Min , Wang Jieying , Zhai Wei , Ye Jiaqi , Chen Minjie , Fang Weilin , Zhang Yeqian , Fu Zhiwei , Shen Yifei , Yan Ziji , Shen Chenlu , Qin Jun , Luo Yanli , Zheng Junhua 
Published: July 2023

ObjectiveThe prevalence of mental distress has been noted in shelter hospitals set up for COVID-19. Potential risk demographic and hospitalization factors were screened. We also aimed to determine whether humanistic care established in the shelter hospital was effective in ameliorating mental distress.MethodsA cross-sectional observational survey-based single-centered study was conducted from 28th April to 5th May 2022 during the COVID-19 pandemic in Shanghai. Asymptomatic adult inpatients and those with mild symptoms were recruited for this study, and humanistic care measures were carried out by the administrative office according to the Work Program on Psychological Assistance and Social Work Services at the Shelter Hospital launched on 5th March 2020. Symptoms of mental distress, such as reported stress, anxiety, depression, and insomnia were measured using the Chinese Stress Response Questionnaire-28, the Chinese version of Generalized Anxiety Disorder-7, Patient Health Questionnaire-9, and Insomnia Severity Index-7, respectively.ResultsIn total, 1,246 out of 9,519 inpatients, including 565 (45.35%) women and 681 (54.65%) men, with a median age of 36 years responded to the survey. The overall prevalence of stress, anxiety, depression, and insomnia in inpatients was 94 (7.54%), 109 (8.75%), 141 (11.32%), and 144 (11.56%), respectively. Mental distress was aggravated by COVID-19-related symptoms, comorbidities, and prolonged hospital stays. A stable internet connection was the most effective measure to reduce stress and depression. Offering inpatient with study or work facilitations, and mental health education help to ameliorate anxiety and depression. Organizing volunteering was a potential protective factor against stress.ConclusionHumanistic care is crucial and effective for protecting against mental distress, which should be emphasized in shelter hospitals.
Behavioral and psychosocial factors related to mental distress among medical students
Authors: Carlos Kathleen M. , Ahmadi Hedyeh , Uban Kristina A. , Riis Jenna L. 
Published: July 2023

IntroductionPhysicians die by suicide at rates higher than the general population, with the increased risk beginning in medical school. To better understand why, this study examined the prevalence of mental distress (e.g., depressive symptoms and suicide risk) and behavioral and psychosocial risk factors for distress, as well as the associations between mental distress and risk factors among a sample of medical students in a pre–COVID-19-era.MethodsStudents enrolled in a large California medical school in 2018–2019 (N = 134; 52% female) completed questionnaires assessing sociodemographic characteristics, depression and suicide family history, health behaviors, and psychosocial wellbeing. Assessment scores indexing mental distress (e.g., depressive symptoms, thoughts of suicide in the past 12 months, suicide risk, and history of suicidality) and risk factors (e.g., stress, subjective sleep quality, alcohol use, impostor feelings, and bill payment difficulty) were compared across biological sex using chi-squared tests, and associations between mental distress and risk factors were determined through logistic regression.ResultsElevated mental distress indicators were observed relative to the general public (e.g., 16% positive depression screen, 17% thought about suicide in previous 12 months, 10% positive suicide risk screen, and 34% history of suicidality), as well as elevated risk factors [e.g., 55% moderate or high stress, 95% at least moderate impostor feelings, 59% poor sleep quality, 50% screened positive for hazardous drinking (more likely in females), and 25% difficulty paying bills]. A positive depression screen was associated with higher stress, higher impostor feelings, poorer sleep quality, and difficulty paying bills. Suicidal ideation in the previous 12 months, suicide risk, and a history of suicidality were independently associated with higher levels of impostor feelings.DiscussionHigher scores on assessments of depressive symptoms and suicidal thoughts and behaviors were related to several individual-level and potentially modifiable risk factors (e.g., stress, impostor feelings, sleep quality, and bill payment difficulties). Future research is needed to inform customized screening and resources for the wellbeing of the medical community. However, it is likely that the modification of individual-level risk factors is limited by the larger medical culture and systems, suggesting that successful interventions mitigate suicide risk for medical providers need to address multiple socio-ecological levels.
Analysis of the Impact of Public Services on Residents’ Health: A Spatial Econometric Analysis of Chinese Provinces
Authors: Jia Wei , Liu Lei , Wang Zhihao , Peng Gang 
Published: July 2023

Objectives: The aim of this study was to explore the mechanism between public services and residents’ health, focusing on the role of spatial geographical factors.Methods: Leveraging a comprehensive panel dataset encompassing 30 mainland Chinese provinces from 2007 to 2019, this study engineered a spatial Durbin model furnished with dual fixed effects through the application of the Lagrange multiplier, Hausman, and likelihood ratio tests. The primary objective was to delve into the repercussions of varying public service levels on residents’ health outcomes.Results: The empirical findings reveal a palpable spatial autocorrelation between residents’ health outcomes and the public services levels dispensed across Chinese provinces. Intriguingly, an elevation in the public service level in a given province not only ameliorates its residents’ health outcomes but also triggers a spatial spillover effect, thereby positively influencing residents’ health in neighboring provinces. The rigorous endogeneity and robustness checks affirm the reliability of the principal outcomes.Conclusion: Due to the increase in social uncertainty, all regions should break free of the administrative monopoly, enhance regional integration and development, and improve residents’ health status by clustering public service supply.
QUALITY OF APBD ACCORDING TO THE PERSPECTIVE OF COMMUNITY PARTICIPATION AND TRANSPARENCY OF PUBLIC POLICY
Authors: Anggadini Sri Dewi , Rohmawati Tatik , Damayanti Sari , Bramasto Ari 
Published: July 2023

This study aims to find out the implementation of community participation and transparency of public policy on the quality of regional budget (APBD) in the South Coastal District Health Office. factors tested in this study are Community Participation and Public Policy Transparency as independent variables. While the quality of APBD as a dependent variable. The method used in this research is descriptive method. The population in this study is all employees of the Sub Division of Finance and Sub Division of Programs and Budget of the South Coast District Health Office. The sampling technique used is using census method (saturated sample), so that the number of samples used is 36 sample data. The data collection method is carried out by distributing questionnaires to employees of the Sub Division of Finance and the Program and Budget Sub-Section of the South Coastal District Health Office. The results showed that the Implementation of Community Participation and Transparency of Public Policy on the Quality of APBD in the South Coastal District Health Office is quite good but not fully optimal, where there is still a lack of participation and transparency carried out.
Keywords: Transparency of Public Policy, Public Participation, Quality of APBD
DAMPAK KEBIJAKAN PELARANGAN PENGGUNAAN CANTRANG PADA NELAYAN CANTRANG DI KECAMATAN BRONDONG KABUPATEN LAMONGAN
Authors: Hanum Alfi Azhari , Saiman Saiman , Sihidi Iradhad Taqwa 
Published: July 2023

This study aims to see the impact of the cantrang prohibition policy issued by the Ministry of Fisheries and Marine Affairs in Brondong District, Lamongan Regency. Through the Regulation of the Minister of Marine Affairs and Fisheries Number 2 of 2015 concerning the Prohibition of Using Hela Trawl and Trawling Fishing Tools in the WPPNRI article 4 paragraph (2), the Indonesian government wants to maintain the sustainability of Indonesia's marine resources which at the same time has negative implications for the income of fishermen and other parties. others. This research is categorized into a descriptive qualitative type, the data obtained using the direct interview method, observation, and documentation that supports this research. Research shows that fishermen and related parties have suffered significant losses due to drastically reduced fish catch, which is contagious to the sluggishness of fish auction and boat building services. There is resistance from fishermen to this policy which can be resolved.
Keywords: Policy Impact, Cantrang Policy, Cantrang.
PENGARUH KETERAMPILAN MENGAJAR GURU DAN FASILITAS BELAJAR TERHADAP MOTIVASI BELAJAR SISWA DI SMA NEGERI 2 TORAJA UTARA
Authors: Yusuf Nugrahadi , Rizaldi Arjuna 
Published: July 2023

Penelitian ini bermaksud untuk mengetahui dan menguji apakah perlu atau tidak perlu pengaruh keterampilan mengajar guru dan fasilitas belajar terhadap motivasi belajar siswa di SMA Negeri 2 Toraja Utara baik secara parsial maupun simultan. Metode penelitian yang dipakai pendekatan kuantitatif, deskriptif dan verifikatif. Penelitian ini memakai metode deskriptif dan verifikatif.Teknik analisis data Responden dalam penelitian ini adalah 93 responden. Teknik penarikan sampel yang digunakan adalah teknik purposive sampling. Alat analisis yang digunakan meliputi analisis regresi linier berganda dan hipotesis menggunakan SPSS v25. Hasil yang diperoleh menunjukkan hasil uji-t menunjukkan adanya pengaruh yang signifikan. Hasil Uji-F juga berpengaruh signifikan terhadap motivasi belajar.
Students’ perspectives on Critical Mathematics Education
Authors: Steflitsch Daniela , Brantlinger Andrew 
Published: July 2023

Theoretically, critical mathematics education (CME) differs markedly from traditional, teacher-centered mathematics teaching approaches. In addition to meeting mathematical goals, a main focus of CME lies on fostering students’ critical consciousness and positioning them as active and informed actors in the classroom and beyond. However, only few empirical studies explicitly focus on how students experience CME instruction and curriculum. In this contribution, we draw on interview data to examine how K-12 students in one Austrian and one American school setting respond to and perceive CME lessons. The analysis revealed that, within both classroom settings, students’ perceptions vary greatly, with some perceiving CME lessons as being completely different from prior experiences in school mathematics to some seeing little-to-no difference. Additionally features of CME instruction that mathematics teachers and researchers might consider to be the most salient are not necessarily the ones that students report attending to. Reasons for that might be manifold, and students might need more time with CME instruction and especially with reflecting on such lessons to identify the rationale behind the instructional approach. Moreover, researchers should be aware that students might not share their understanding of critical instructional reforms and might have diverse or even divergent perceptions.
EFEKTIVITAS PENGOLAHAN AIR LIMBAH KERUPUK KULIT MENGGUNAKAN METODDE BIOFILTER ANAEROB DALAM MENURUNKAN BOD5, COD DAN TSS
Authors: Wijanarko Igo , Prasetyo Suseno Hadi , Sunarsih Sri 
Published: July 2023

Air limbah kerupuk kulit (krecek) mengandung polutan organik yang tinggi, memiliki karakteristik warna coklat keputih-putihan, berbau cukup menyengat, suhu 25°C, pH 6 dan permukaan air limbah kerupuk kulit terlihat minyak yang cukup tebal.
Penelitian ini dilakukan untuk menganalisis kualitas air limbah kerupuk kulit dengan membuat reaktor biofilter anaerob dengan media bioball dalam menurunkan kadar BOD5, COD serta TSS. Air limbah kerupuk kulit dialirkan ke dalam reaktor biofilter anaerob untuk menentukan efektivitas waktu tinggal dalam menurunkan kadar BOD5, COD serta TSS dengan variasi waktu tinggal yaitu 24 jam, 48 jam, 72 jam dan 96 jam.
Hasil pemeriksaan sampling limbah cair kerupuk kulit, untuk BOD5 5.680 mg/L, untuk COD 25.557 mg/L, dan untuk TSS 593 mg/L Variasi waktu tinggal yang dilakukan sampai dengan waktu tinggal 96 jam, didapatkan hasil efisiensi penurunan tertinggi pada waktu tinggal 96 jam, untuk BOD5 yaitu 642mg/L sebesar 88,7%, untuk COD yaitu 2542,2mg/L sebesar 90,05%, dan untuk TSS yaitu 41mg/L sebesar 93,1%.
Bounds and Extremal Graphs for Total Dominating Identifying Codes
Authors: Foucaud Florent , Lehtilä Tuomo 
Published: July 2023

An identifying code $C$ of a graph $G$ is a dominating set of $G$ such that any two distinct vertices of $G$ have distinct closed neighbourhoods within $C$. The smallest size of an identifying code of $G$ is denoted $\gamma^{\text{ID}}(G)$. When every vertex of $G$ also has a neighbour in $C$, it is said to be a total dominating identifying code of $G$, and the smallest size of a total dominating identifying code of $G$ is denoted by $\gamma_t^{\text{ID}}(G)$.
Extending similar characterizations for identifying codes from the literature, we characterize those graphs $G$ of order $n$ with $\gamma_t^{\text{ID}}(G)=n$ (the only such connected graph is $P_3$) and $\gamma_t^{\text{ID}}(G)=n-1$ (such graphs either satisfy $\gamma^{\text{ID}}(G)=n-1$ or are built from certain such graphs by adding a set of universal vertices, to each of which a private leaf is attached).
Then, using bounds from the literature, we remark that any (open and closed) twin-free tree of order $n$ has a total dominating identifying code of size at most $\frac{3n}{4}$. This bound is tight, and we characterize the trees reaching it. Moreover, by a new proof, we show that this upper bound actually holds for the larger class of all twin-free graphs of girth at least 5. The cycle $C_8$ also attains the upper bound. We also provide a generalized bound for all graphs of girth at least 5 (possibly with twins).
Finally, we relate $\gamma_t^{\text{ID}}(G)$ to the similar parameter $\gamma^{\text{ID}}(G)$ as well as to the location-domination number of $G$ and its variants, providing bounds that are either tight or almost tight.