bluuebunny/crossref_metadata_2025_split huggingface dataset:
HyWay
Authors: Vijay Harsh , Pushp Saumay , Mittal Amish , Gupta Praveen , Gupta Meghna , Gambhira Sirish , Chopra Shivang , Baranwal Mayank , Arya Arshia , Manchepalli Ajay , Padmanabhan Venkata N. 
Published: June 2023

We present HyWay, short for "Hybrid Hallway", to enable mingling and informal interactions among physical and virtual users, in casual spaces and settings, such as office water cooler areas, conference hallways, trade show floors, and more. We call out how the hybrid and unstructured (or semi-structured) nature of such settings set these apart from the all-virtual and/or structured settings considered in prior work. Key to the design of HyWay is bridging the awareness gap between physical and virtual users, and providing the virtual users the same agency as physical users.
To this end, we have designed HyWay to incorporate reciprocity (users can see and hear others only if they can be seen and heard), porosity (conversations in physical space are porous and not within airtight compartments), and agency (the ability for users to seamlessly move between conversations). We present our implementation of HyWay and the user survey findings from multiple deployments in unstructured settings (e.g., social gatherings), and semi-structured ones (e.g., a poster event). Results from these deployments show that HyWay enables effective mingling between physical and virtual users.
On the Long-Term Effects of Continuous Keystroke Authentication
Authors: Huh Jun Ho , Kwag Sungsu , Kim Iljoo , Popov Alexandr , Park Younghan , Cho Geumhwan , Lee Juwon , Kim Hyoungshick , Lee Choong-Hoon 
Published: June 2023

One of the main challenges in deploying a keystroke dynamics-based continuous authentication scheme on smartphones is ensuring low error rates over time. Unstable false rejection rates (FRRs) would lead to frequent phone locks during long-term use, and deteriorating attack detection rates would jeopardize its security benefits. The fact that it is undesirable to train complex deep learning models directly on smartphones or send private sensor data to servers for training present unique deployment constraints, requiring on-device solutions that can be trained fully on smartphones.
To improve authentication accuracy while satisfying such real-world deployment constraints, we propose two novel feature engineering techniques: (1) computation of pair-wise correlations between accelerometer and gyroscope sensor values, and (2) on-device feature extraction technique to compute dynamic time warping (DTW) distance measurements between autoencoder inputs and outputs via transfer-learning. Using those two feature sets in an ensemble blender, we achieved 6.4 percent equal error rate (EER) in a public dataset. In comparison, blending two state-of-the-art solutions achieved 14.1 percent EER in the same test settings. Our real-world dataset evaluation showed increasing FRRs (user frustration) over two months; however, through periodic model retraining, we were able to maintain average FRRs around 2.5 percent while keeping attack detection rates around 89 percent. The proposed solution has been deployed in the latest Samsung Galaxy smartphone series to protect secure workspace through continuous authentication.
Shelter from the Storm: Disaster Capitalism and Puerto Rican Undergraduates in Post–Hurricane María Stateside Higher Education
Authors: Garcia Nichole Margarita , Danek Vanessa 
Published: June 2023

Background/Context: Our study takes an asset-based approach to examine the experiences of Puerto Rican undergraduates and the consequences of cascading disasters (e.g., hurricanes, earthquakes, COVID-19). Puerto Rican undergraduates were prone to vulnerability during cascading disasters because they lacked emergency supplies (e.g., flashlights), effective communication pre- and postdisaster (e.g., texts), and/or knowledge of disaster-related procedures on campus. Purpose/Objective/Research Question/Focus of Study: In this article, we use disaster capitalism and the trauma doctrine as our theoretical underpinnings to address the colonial relationship between the United States and Puerto Rico, in which Puerto Ricans have experienced disaster as an ongoing process illuminated by the sociopolitical and sociohistorical contexts that only exacerbate a longer history of deep-seated colonial traumas. Research Design: This study employs disaster capitalism and the trauma doctrine as a theoretical guide to depict an anticolonial approach and provide a thick description of the multiple case study design bounded by the phenomenon of disaster across two units of analyses from 2017 to 2020. The first unit of analysis (case 1) demonstrates how the public education sector has been diminishing in Puerto Rico due to investments, in this instance, in stateside institutes of higher education (IHEs) through hurricane relief programs. The second unit of analysis (case 2) shows how increasingly paramount it is to examine the experiences of Puerto Rican undergraduates left prone to these vulnerabilities. Conclusions/Recommendations: The theoretical application and findings from our study demonstrate that based on the intersections of disaster capitalism and the trauma doctrine, Puerto Rican undergraduates have and are still experiencing deep-seated trauma masked in disaster “relief” and “recovery” at the hands of the U.S. government and IHEs. These provide an understanding of disaster at the national, institutional, and individual levels.
Continuous and deep sedation until death after a decision to withdraw life-sustaining therapies in intensive care units: A national survey
Authors: Le Dorze Matthieu , Barthélémy Romain , Giabicani Mikhael , Audibert Gérard , Cousin François , Gakuba Clément , Robert René , Chousterman Benjamin , Perrigault Pierre-François ,   The SFAR Research Network and The SEDALAT-REA-Group*
Published: June 2023

Background: Continuous and deep sedation until death is a much highly debated end-of-life practice. France is unique in having a regulatory framework for it. However, there are no data on its practice in intensive care units (ICUs). Aim: The aim is to describe continuous and deep sedation in relation to the framework in the specific context of withdrawal of life-sustaining therapies in ICUs, that is, its decision-making process and its practice compared to other end-of-life practices in this setting. Design and setting: French multicenter observational study. Consecutive ICU patients who died after a decision to withdraw life-sustaining therapies. Results: A total of 343 patients in 57 ICUs, 208 (60%) with continuous and deep sedation. A formalized procedure for continuous and deep sedation was available in 32% of the ICUs. Continuous and deep sedation was not the result of a collegial decision-making process in 17% of cases, and did not involve consultation with an external physician in 29% of cases. The most commonly used sedative medicines were midazolam (10 [5–18] mg h−1) and propofol (200 [120–250] mg h −1). The Richmond Agitation Sedation Scale (RASS) was −5 in 60% of cases. Analgesia was associated with sedation in 94% of cases. Compared with other end-of-life sedative practices ( n = 98), medicines doses were higher with no difference in the depth of sedation. Conclusions: This study shows a poor compliance with the framework for continuous and deep sedation. It highlights the need to formalize it to improve the decision-making process and the match between the intent, the practice and the actual effect.
Minimum 10-Year Outcomes After Arthroscopic Repair of Partial-Thickness Supraspinatus Rotator Cuff Tears
Authors: Dey Hazra Rony-Orijit , Dey Hazra Maria E. , Hanson Jared A. , Rutledge Joan C. , Doan Kent C. , Horan Marilee P. , Millett Peter J. 
Published: June 2023

Background: The prevalence of partial-thickness rotator cuff tears (PTRCTs) has been reported to be 13% to 40% within the adult population, accounting for 70% of all rotator cuff tears. Approximately 29% of PTRCTs will progress to full-thickness tears if left untreated. The long-term clinical course after arthroscopic repair of PTRCTs is not well known. Purpose: To investigate minimum 10-year patient-reported outcomes (PROs) after arthroscopic rotator cuff repair (RCR) of the supraspinatus tendon and to report reoperation and complication rates. Study Design: Case series; Level of evidence, 4. Methods: Patients were included who underwent arthroscopic RCR of a PTRCT performed by a single surgeon between October 2005 and October 2011. Arthroscopic RCR was performed with a transtendon repair of partial, articular-sided supraspinatus tendon avulsions, bursal-sided repair, or conversion into a full-thickness tear and repair. PRO data were collected preoperatively and at a minimum 10 years postoperatively. PRO measures included the American Shoulder and Elbow Surgeons score, Single Assessment Numeric Evaluation score, the shortened version of Disabilities of the Arm, Shoulder and Hand score (QuickDASH), the 12-Item Short Form Health Survey Physical Component Summary, and patient satisfaction. Subanalyses were performed to determine if tear location or age was associated with outcomes. Retears, revision surgery, and surgical complications were recorded. Results: In total, 33 patients (21 men, 12 women) at a mean age of 50 years (range, 23-68) met criteria for inclusion. Follow-up was obtained in 28 (87.5%) of the 32 eligible patients ≥10 years out from surgery (mean, 12 years; range, 10-15 years). Of the 33 PTCRTs, 21 were articular sided and 12 were bursal sided. Of the 33 patients, 26 underwent concomitant biceps tenodesis. At follow-up, the mean PROs were significantly improved when compared with preoperative levels: American Shoulder and Elbow Surgeons score from 67.3 to 93.7 ( P < .001), Single Assessment Numeric Evaluation from 70.9 to 91.2 ( P = .004), QuickDASH from 22.3 to 6.6 ( P < .004), and 12-Item Short Form Health Survey Physical Component Summary from 44.8 to 54.2 ( P < .001). Median postoperative satisfaction was 10 (range, 5-10). No patient underwent revision surgery. Conclusion: Arthroscopic repair of PTRCTs results in excellent clinical outcomes and high patient satisfaction at minimum 10-year follow-up. Furthermore, the procedure is highly durable, with a clinical survivorship rate of 100% at 10 years.
Safety of fecal microbiota, live-jslm (REBYOTA™) in individuals with recurrent Clostridioides difficile infection: data from five prospective clinical trials
Authors: Lee Christine , Louie Thomas , Bancke Lindy , Guthmueller Beth , Harvey Adam , Feuerstadt Paul , Khanna Sahil , Orenstein Robert , Dubberke Erik R. 
Published: June 2023

Background: Microbiota-based treatments reduce the incidence of recurrent Clostridioides difficile infections (rCDIs), but prospectively collected safety data needed to broaden patient access and protect public health have been limited. Objectives: We provide cumulative safety data from five prospective clinical trials evaluating fecal microbiota, live-jslm (RBL) – the first microbiota-based live biotherapeutic product approved by the US Food and Drug Administration – for preventing rCDI in adults. Design: Integrated safety analysis includes three phase II trials (PUNCH CD, PUNCH CD2, PUNCH Open-Label) and two phase III trials (PUNCH CD3, PUNCH CD3-OLS) of RBL. Methods: Trial participants were at least 18 years of age with documented rCDI who completed standard-of-care antibiotic therapy before treatment with RBL. Assigned study treatment regimen was one or two doses of RBL (or placebo) administered rectally, depending on the trial design. In four of the five trials, participants with CDI recurrence within 8 weeks after RBL or placebo administration were eligible for treatment with open-label RBL. Treatment-emergent adverse events (TEAEs) were recorded for at least 6 months following last study treatment; in PUNCH CD2 and PUNCH Open-Label trials, TEAEs and serious TEAEs were collected through 12 and 24 months, respectively. Results: Among the five trials, 978 participants received at least one dose of RBL (assigned treatment or after recurrence) and 83 participants received placebo only. TEAEs were reported in 60.2% of Placebo Only participants and 66.4% of RBL Only participants. Only abdominal pain, nausea, and flatulence were significantly higher in the RBL Only group compared with the Placebo Only group. Most TEAEs were mild or moderate in severity and were most frequently related to preexisting conditions. There were no reported infections for which the causative pathogen was traced to RBL. Potentially life-threatening TEAEs were infrequent (3.0% of participants). Conclusion: Across five clinical trials, RBL was well tolerated in adults with rCDI. In aggregate, these data consistently demonstrated the safety of RBL.
The feasibility and effectiveness of telecare consultations in nurse-led post-acute stroke clinics: A study protocol
Authors: Wong Arkers Kwan Ching , Bayuo Jonathan , Wong Frances Kam Yuet , Kwok Vivian Wai Yan , Yuen Bernard Man Kam , Fong Ching Sing , Chan Shun Tim , Pung Hoi Lam , Kwek Oi Lam 
Published: June 2023

Background Globally, nurse-led post-acute stroke clinics have been developed to provide secondary care services to stroke survivors. Although synthesized evidence supports the idea that the secondary prevention services delivered by nurses in these clinics can improve the functional ability of stroke survivors and reduce their readmission rates, long travel and waiting times, high costs, and the pandemic have limited the utilization of such clinics. Telecare consultations are a new modality for expanding public access to healthcare services, although how it can be applied in nurse-led clinics has not been reported. Objective The aim of this study is to determine the feasibility and effects of telecare consultations in nurse-led post-acute stroke clinics. Methods The study adopts a quasi-experimental design. The participants will receive three secondary stroke care consultations in 3 months provided via telecare by experienced advanced practice nurses. The outcome measures include feasibility (reasons for refusing to participate and for dropping-out, the attitudes and satisfaction of both the advanced practice nurses and their patients towards the programme), and preliminary effectiveness (degree of disability after stroke, activities of daily living, instrumental activities of daily living, health-related quality of life, depression) outcomes. Data will be collected at pre-(T1) and post-(T2) intervention. Conclusions The findings of this study may help facilitate the implementation of telecare consultations in a nurse-led post-acute stroke clinic, which may benefit the stroke survivors who are having mobility restrictions from accessing customary healthcare services and may protect them from being exposed to the infectious risk.
Platelet functional abnormalities in pediatric patients with kaposiform hemangioendothelioma/Kasabach-Merritt phenomenon
Authors: Martyanov Alexey A. , Tesakov Ivan P. , Khachatryan Lili A. , An Olga I. , Boldova Anna E. , Ignatova Anastasia A. , Koltsova Ekaterina M. , Korobkin Julia-Jessica D. , Podoplelova Nadezhda A. , Svidelskaya Galina S. , Yushkova Eugenia , Novichkova Galina A. , Eble Johannes A. , Panteleev Mikhail A. , Kalinin Dmitrii V. , Sveshnikova Anastasia N. 
Published: June 2023

Abstract
Kaposiform hemangioendothelioma (KHE) is a rare vascular tumor of infancy that is commonly associated with a life-threatening thrombocytopenic condition, Kasabach-Merritt phenomenon (KMP). Platelet CLEC-2, tumor podoplanin interaction is considered the key mechanism of platelet clearance in these patients. Here, we aimed to assess platelet functionality in such patients. Three groups of 6 to 9 children were enrolled: group A with KHE/KMP without hematologic response (HR) to therapy; group B with KHE/KMP with HR; and group C with healthy children. Platelet functionality was assessed by continuous and end point flow cytometry, low-angle light scattering analysis (LaSca), fluorescent microscopy of blood smears, and ex vivo thrombi formation. Platelet integrin activation in response to a combination of CRP (GPVI agonist) and TRAP-6 (PAR1 agonist), as well as calcium mobilization and integrin activation in response to CRP or rhodocytin (CLEC-2 agonist) alone, were significantly diminished in groups A and B. At the same time, platelet responses to ADP with or without TRAP-6 were unaltered. Thrombi formation from collagen in parallel plate flow chambers was also noticeably decreased in groups A and B. In silico analysis of these results predicted diminished amounts of CLEC-2 on the platelet surface of patients, which was further confirmed by immunofluorescence microscopy and flow cytometry. In addition, we also noted a decrease in GPVI levels on platelets from group A. In KHE/KMP, platelet responses induced by CLEC-2 or GPVI activation are impaired because of the diminished number of receptors on the platelet surface. This impairment correlates with the severity of the disease and resolves as the patient recovers.
The value of sonication in the differential diagnosis of septic and aseptic femoral and tibial shaft nonunion in comparison to conventional tissue culture and histopathology: a prospective multicenter clinical study
Authors: Trenkwalder Katharina , Erichsen Sandra , Weisemann Ferdinand , Augat Peter , Militz Matthias , von Rüden Christian , Hentschel Tobias ,   SAND Research Group, Baumgartner Heiko , Reumann Marie , Reiter Georg , Freischmidt Holger , Kemmerer Matthias , Langwald Steffen , Hanke John , Glombitza Martin , Steinhausen Eva , Gerlach Ulf-Joachim , Spranger Nikolai , Stengel Dirk , Hackl Simon 
Published: June 2023

Abstract
Background
Septic and aseptic nonunion require different therapeutic strategies. However, differential diagnosis is challenging, as low-grade infections and biofilm-bound bacteria often remain undetected. Therefore, the examination of biofilm on implants by sonication and the evaluation of its value for differentiating between femoral or tibial shaft septic and aseptic nonunion in comparison to tissue culture and histopathology was the focus of this study.

Materials and methods
Osteosynthesis material for sonication and tissue samples for long-term culture and histopathologic examination from 53 patients with aseptic nonunion, 42 with septic nonunion and 32 with regular healed fractures were obtained during surgery. Sonication fluid was concentrated by membrane filtration and colony-forming units (CFU) were quantified after aerobic and anaerobic incubation. CFU cut-off values for differentiating between septic and aseptic nonunion or regular healers were determined by receiver operating characteristic analysis. The performances of the different diagnostic methods were calculated using cross-tabulation.

Results
The cut-off value for differentiating between septic and aseptic nonunion was ≥ 13.6 CFU/10 ml sonication fluid. With a sensitivity of 52% and a specificity of 93%, the diagnostic performance of membrane filtration was lower than that of tissue culture (69%, 96%) but higher than that of histopathology (14%, 87%). Considering two criteria for infection diagnosis, the sensitivity was similar for one tissue culture with the same pathogen in broth-cultured sonication fluid and two positive tissue cultures (55%). The combination of tissue culture and membrane-filtrated sonication fluid had a sensitivity of 50%, which increased up to 62% when using a lower CFU cut-off determined from regular healers. Furthermore, membrane filtration demonstrated a significantly higher polymicrobial detection rate compared to tissue culture and sonication fluid broth culture.

Conclusions
Our findings support a multimodal approach for the differential diagnosis of nonunion, with sonication demonstrating substantial usefulness.
Level of Evidence: Level 2
Trial registration DRKS00014657 (date of registration: 2018/04/26)
Orthogonal proteomics methods warrant the development of Duchenne muscular dystrophy biomarkers
Authors: Johansson Camilla , Hunt Helian , Signorelli Mirko , Edfors Fredrik , Hober Andreas , Svensson Anne-Sophie , Tegel Hanna , Forstström Björn , Aartsma-Rus Annemieke , Niks Erik , Spitali Pietro , Uhlén Mathias , Szigyarto Cristina Al-Khalili 
Published: June 2023

AbstractBackgroundMolecular components in blood, such as proteins, are used as biomarkers to detect or predict disease states, guide clinical interventions and aid in the development of therapies. While multiplexing proteomics methods promote discovery of such biomarkers, their translation to clinical use is difficult due to the lack of substantial evidence regarding their reliability as quantifiable indicators of disease state or outcome. To overcome this challenge, a novel orthogonal strategy was developed and used to assess the reliability of biomarkers and analytically corroborate already identified serum biomarkers for Duchenne muscular dystrophy (DMD). DMD is a monogenic incurable disease characterized by progressive muscle damage that currently lacks reliable and specific disease monitoring tools.MethodsTwo technological platforms are used to detect and quantify the biomarkers in 72 longitudinally collected serum samples from DMD patients at 3 to 5 timepoints. Quantification of the biomarkers is achieved by detection of the same biomarker fragment either through interaction with validated antibodies in immuno-assays or through quantification of peptides by Parallel Reaction Monitoring Mass Spectrometry assay (PRM-MS).ResultsFive, out of ten biomarkers previously identified by affinity-based proteomics methods, were confirmed to be associated with DMD using the mass spectrometry-based method. Two biomarkers, carbonic anhydrase III and lactate dehydrogenase B, were quantified with two independent methods, sandwich immunoassays and PRM-MS, with Pearson correlations of 0.92 and 0.946 respectively. The median concentrations of CA3 and LDHB in DMD patients was elevated in comparison to those in healthy individuals by 35- and 3-fold, respectively. Levels of CA3 vary between 10.26 and 0.36 ng/ml in DMD patients whereas those of LDHB vary between 15.1 and 0.8 ng/ml.ConclusionsThese results demonstrate that orthogonal assays can be used to assess the analytical reliability of biomarker quantification assays, providing a means to facilitate the translation of biomarkers to clinical practice. This strategy also warrants the development of the most relevant biomarkers, markers that can be reliably quantified with different proteomics methods.