bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Multifunctional Nanozyme with NADH Dehydrogenase‐Like Activity and Nitric Oxide Release under Near‐Infrared Light Irradiation as an Efficient Therapeutic for Antimicrobial Resistance Infection and Wound Healing
Authors: Wang Yi , Shi Hong‐dong , Zhang Hai‐Lin , Yu Chen Yu‐ , Ren Bing , Tang Qi , Sun Qi , Zhang Qian‐Ling , Liu Jin‐Gang 
Published: June 2023

AbstractIn recent years, antimicrobial resistance (AMR) has become one of the greatest threats to human health. There is an urgent need to develop new antibacterial agents to effectively treat AMR infection. Herein, a novel nanozyme platform (Cu,N‐GQDs@Ru‐NO) is prepared, where Cu,N‐doped graphene quantum dots (Cu,N‐GQDs) are covalently functionalized with a nitric oxide (NO) donor, ruthenium nitrosyl (Ru‐NO). Under 808 nm near‐infrared (NIR) light irradiation, Cu,N‐GQDs@Ru‐NO demonstrates nicotinamide adenine dinucleotide (NADH) dehydrogenase‐like activity for photo‐oxidizing NADH to NAD+, thus disrupting the redox balance in bacterial cells and resulting in bacterial death; meanwhile, the onsite NIR light‐delivered NO effectively eradicates the methicillin‐resistant Staphylococcus aureus (MRSA) bacterial and biofilms, and promotes wound healing; furthermore, the nanozyme shows excellent photothermal effect that enhances the antibacterial efficacy as well. With the combination of NADH dehydrogenase activity, photothermal therapy, and NO gas therapy, the Cu,N‐GQDs@Ru‐NO nanozyme displays both in vitro and in vivo excellent efficacy for MRSA infection and biofilm eradication, which provides a new therapeutic modality for effectively treating MRSA inflammatory wounds.
Revolutionizing Porous Liquids: Stabilization and Structural Engineering Achieved by a Surface Deposition Strategy
Authors: Qiu Liqi , Peng Honggen , Yang Zhenzhen , Fan Juntian , Li Meijia , Yang Shize , Driscoll Darren M. , Ren Lei , Mahurin Shannon M. , He Liang‐Nian , Dai Sheng 
Published: June 2023

AbstractFacile approaches capable of constructing stable and structurally diverse porous liquids (PLs) that can deliver high‐performance applications are a long‐standing, captivating, and challenging research area that requires significant attention. Herein, a facile surface deposition strategy is demonstrated to afford diverse type III‐PLs possessing ultra‐stable dispersion, external structure modification, and enhanced performance in gas storage and transformation by leveraging the expeditious and uniform precipitation of selected metal salts. The Ag(I) species‐modified zeolite nanosheets are deployed as the porous host to construct type III‐PLs with ionic liquids (ILs) containing bromide anion , leading to stable dispersion driven by the formation of AgBr nanoparticles. The as‐afforded type‐III PLs display promising performance in CO2 capture/conversion and ethylene/ethane separation. Property and performance of the as‐produced PLs can be tuned by the cation structure of the ILs, which can be harnessed to achieve polarity reversal of the porous host via ionic exchange. The surface deposition procedure can be further extended to produce PLs from Ba(II)‐functionalized zeolite and ILs containing [SO4]2− anion driven by the formation of BaSO4 salts. The as‐produced PLs are featured by well‐maintained crystallinity of the porous host, good fluidity and stability, enhanced gas uptake capacity, and attractive performance in small gas molecule utilization.
Bioinspired Luminescent HOF‐Based Foam as Ultrafast and Ultrasensitive Pressure and Acoustic Bimodal Sensor for Human–Machine Interactive Object and Information Recognition
Authors: Xu Xin , Yan Bing 
Published: June 2023

AbstractBionic sensors have extensively served smart robots, medical equipment, and flexible wearable devices. The luminescent pressure‐acoustic bimodal sensor can be treated as a remarkable, multifunctional, integrated bionic device. Here, a blue‐emitting hydrogen‐bonded organic framework (HOF‐TTA) as luminogen combines with melamine foam (MF), generating the flexible and elastic HOF‐TTA@MF (1 and 2) as a pressure–auditory bimodal sensor. In the luminescent pressure sensing process, 1 has excellent maximum sensitivity (132.02 kPa−1), low minimum detection limit (0.0 1333 Pa), fast response time (20 ms), high precision and great recyclability. 2 as a luminescent auditory sensor exhibits the highest response to the 520 Hz sound at 255−1453 Hz. In the process of sensing sound at 520 Hz, 2 possesses high sensitivity (1 648 441.3 cps Pa−1 cm−2), low detection limit (0.36 dB) and ultrafast response time (10 ms) within 11.47−91.77 dB. The sensing mechanisms toward pressure and auditory are analyzed in detail by finite element simulation. Furthermore, 1 and 2, as a human–machine interactive bimodal sensor, can recognize nine different objects and word information of “Health”, “Phone”, and “TongJi” with high accuracy and strong robustness. This work provides a facile fabricated method of luminescent HOF‐based pressure–auditory bimodal sensors and endows them with new recognition functions and dimensions.
Lattice Strain Regulation Enables High‐Performance Formamidinium Perovskite Photovoltaics
Authors: Wang Rui , Li Xinhao , Qi Jiahui , Su Chao , Yang Jien , Yang Shaopeng , Yuan Mingjian , He Tingwei 
Published: June 2023

AbstractFormamidinium lead iodide (FAPbI3) perovskite possesses an ideal optical bandgap and is a potential material for fabricating the most efficient single‐junction perovskite solar cells (PSCs). Nevertheless, large formamidinium (FA) cations result in residual lattice strain, which reduces the power conversion efficiency (PCE) and operational stability of PSCs. Herein, the modulation of lattice strain in FAPbI3 crystals via a π‐conjugated organic amine, i.e., 4‐pyrene oxy butylamine (PYBA), is proposed. PYBA pairs at the grain boundary serve as a template for the crystallization of FAPbI3 perovskite, thereby inducing a highly oriented crystal and a pure α‐phase film. The PYBA pairs with strong π–π interactions provide a solid fulcrum for external compression strain, thus compensating for the inherent tension strain of FAPbI3 crystals. The strain release elevates the valence band of the perovskite crystals, thereby decreasing the bandgap and trap density. Consequently, the PYBA‐regulated FAPbI3 PSC achieves an excellent PCE of 24.76%. Moreover, the resulting device exhibits improves operational stability and maintains over 80% of its initial PCE after 1500 h under maximum power point tracking conditions.
How to Adequately Describe Full Range Intercalation—A Two‐Sided Approach
Authors: Zhu Yue , Maier Joachim 
Published: June 2023

AbstractOne of the key challenges in battery research is to quantitatively describe the intercalation storage capacity as a function of the reversible cell voltage. The reason that such endeavors are not yet very successful, lies in the lack of an adequate charge carrier treatment. Using the most challenging example of nanocrystalline lithium iron phosphate, where the full range from FePO4 to LiFePO4 is accessible without miscibility gap, this study shows how a quantitative description of literature results can be achieved even for such a huge window. For this purpose, point‐defect thermodynamics is applied and the problem is tackled from the two end‐member sides including saturation effects. A first, rather heuristic treatment interpolates in‐between using the safe thermodynamic criterion of local phase stability. Already this straightforward approach works very satisfactorily. In order to also gain mechanistic insight, interactions among and between ions and electrons have to be taken account of. This study shows how to implement them into the analysis.
Jointless Bioinspired Soft Robotics by Harnessing Micro and Macroporosity
Authors: Joe Seonggun , Bliah Ouriel , Magdassi Shlomo , Beccai Lucia 
Published: June 2023

AbstractAlthough natural continuum structures, such as the boneless elephant trunk, provide inspiration for new versatile grippers, highly deformable, jointless, and multidimensional actuation has still not been achieved. The challenging pivotal requisites are to avoid sudden changes in stiffness, combined with the capability of providing reliable large deformations in different directions. This research addresses these two challenges by harnessing porosity at two levels: material and design. Based on the extraordinary extensibility and compressibility of volumetrically tessellated structures with microporous elastic polymer walls, monolithic soft actuators are fabricated by 3D printing unique polymerizable emulsions. The resulting monolithic pneumatic actuators are printed in a single process and are capable of bidirectional movements with just one actuation source. The proposed approach is demonstrated by two proof‐of‐concepts: a three‐fingered gripper, and the first ever soft continuum actuator that encodes biaxial motion and bidirectional bending. The results open up new design paradigms for continuum soft robots with bioinspired behavior based on reliable and robust multidimensional motions.
New and simple synthetic strategy for two‐dimensional ultra‐microporous aromatic framework for selective uranium capture in liquid
Authors: Ahmad Mudasir , Ren Jianquan , Naik Mehraj‐ud‐din , Wang Yabin , Khosla Ajit , Zhang Qiuyu , Zhang Baoliang 
Published: June 2023

AbstractUranium is a key element to improve nuclear energy demands, and thereby the extraction of uranium from seawater is a strategic way to address uranium sustainability. Herein, a novel two‐dimensional porous aromatic framework (AO‐PAF), which possesses an ultra‐microporous architecture with an ordered structure, excellent stability and selectivity of uranium extraction from a liquid phase. AO‐PAF shows excellent uranium adsorption capacities of 637 (mg/g) and 3.22 (mg/g) in simulated and natural seawater attributable to the selective uranium coordinating groups on highly accessible pores on the walls of open channels. In addition, benefiting from the super‐hydrophilicity due to the presence of amidoxime groups attributes high selectivity and ultrafast kinetics with an uptake rate of 0.43 ± 0.03 (mg/g·day) and allowing half‐saturation within 1.35 ± 0.09 days. This strategy demonstrates the potential of PAF not only recovery of uranium and can be extended for other applications by sensible planning of target ligands.
Desymmetrization of Oxabenzonorbornadienes through Brønsted Acid‐Catalyzed Enantioselective (3+2) Cycloaddition with Hydrazones
Authors: Prieto Liher , Reyes Efraim , Uria Uxue , Carrillo Luisa , Vicario Jose L. 
Published: June 2023

AbstractThis work presents the desymmetrization of oxabenzonorbornadienes through the (3+2) cycloaddition reaction with hydrazones using a chiral Brønsted acid such as a BINOL‐derived phosphoramide. This chiral acid catalyst appears as the most effective mediator for the activation of the hydrazone via hydrazonium cation that reacts in a (3+2) fashion with the oxabenzonorbornadiene as the olefinic counterpart. Under the optimized conditions, the reaction provided selectively exo cycloaddition products in satisfactory yields and moderate stereoselectivities. The scope of the reaction was explored displaying 21 examples of these highly functionalized tetrahydroepoxybenzoindazole compounds. A reaction mechanism is proposed to explain the outcome of the reaction.
Version comparison of AccuBrain for automated brain volumetry regarding accuracy, reproducibility and application for diagnosis
Authors: Zhao Lei , Luo Yishan , Mok Vincent C.T. , Shi Lin ,   the Alzheimer Disease Neuroimaging Initiative
Published: June 2023

AbstractBackgroundAutomated brain volumetry has been widely used to assess brain volumetric changes that may indicate clinical states and progression. Among the tools that implement automated brain volumetry, AccuBrain has been validated for its accuracy, reliability and clinical applications for the older version (IV1.2). Recently, AccuBrain underwent a substantial revision update (IV2.0) for segmentation algorithms. Here, we aim to compare the performance of the two versions of AccuBrain for future use from several aspects.MethodPublic datasets with 3D T1‐weighted scans were included for version comparisons, each with Alzheimer’s disease (AD) patients and normal control (NC) subjects that were matched in age and gender (Table 1). For the comparisons of the brain volumetric measures quantified from the same scans, we investigated the difference of hippocampal segmentation accuracy (using Dice similarity coefficient [DSC] as the major measurement). As AccuBrain generates a composite index (AD resemblance atrophy index, AD‐RAI) that indicates similarity with AD‐like brain atrophy pattern, we also compared the two versions for the diagnostic accuracy of AD vs. NC with AD‐RAI. Also, we examined the intra‐scanner reproducibility of the two versions for the scans acquired with short‐intervals using intraclass correlation coefficient (ICC).ResultRegarding hippocampal segmentation, AccuBrain IV2.0 presented significantly higher accuracy than IV1.2 with manual segmentation as the reference, both in the entire cohort (DSC: 0.91 vs. 0.89, p<0.001) and in the subgroups (all with p<0.001) defined by diagnosis, field strength or manufacturer (Table 2 and Figure 1). Also, AccuBrain IV2.0 showed better diagnostic accuracy of AD (AUC: 0.977 vs. 0.921, p<0.001) than IV1.2 (Figure 2). Regarding the analyses of intra‐scanner reproducibility (Table 3 and Table 4), the point estimates of ICC values were all >0.95 for absolute volumes and AD‐RAI, and generally >0.90 for relative volumetric measures. These two versions generally presented no significant differences for ICC values for most brain volumetric measures in NC or AD.ConclusionAccuBrain IV2.0 presented better segmentation accuracy and diagnostic accuracy of AD, and similar intra‐scanner reproducibility compared with IV1.2. Both versions should be feasible for use due to the small magnitude of differences.
Management of epilepsy in Alzheimer’s disease in Down syndrome
Authors: Altuna Miren , Sierra Alba , Carmona‐Iragui Maria , Fernandez Susana , Barroeta Isabel , Giménez Sandra , Arranz Javier , Pegueroles Jordi , Ribas Laia , Videla Laura , Benejam Bessy , Padilla Concepcion , Iulita M. Florencia , Blesa Rafael , Lleó Alberto , Fortea Juan 
Published: June 2023

AbstractIntroductionDown syndrome (DS) is a genetically determined form of Alzheimer’s disease (AD) and a specific form of epilepsy is strongly associated with AD in DS (DSAD), late onset myoclonic epilepsy (LOMEDs), but, there are no clinical trials evaluating the efficacy and tolerability of antiseizure medications in this epilepsyAimsTo describe our experience in the treatment of LOMEDs.Material and MethodsWe recruited patients with symptomatic AD (prodromal –pAD‐ or AD dementia –dAD‐ stages) in the context of a health plan for adult population with DS between January 2013 and November 2021. This health plan included semiannual follow‐ups (or as clinically needed) and an anamnesis and structured questionnaire including the personal history of epilepsy (duration of epilepsy, semiology, frequency, efficacy and tolerability of ASM).ResultsThe study included 72 patients with pAD (48.6% females) and 257 with dAD (50.6% females). Bilateral tonic‐clonic seizures (BTCS) were the most frequent type (85.7% in pAD and 70.7% in dDS) and frequentlly coexisted with myoclonic seizures (16.7% and 57.6% in pDS and dAD respectively). The most frequent treatment after the first seizure was levetiracetam (LEV) (61.5%) followed by valproate (VPA) (19.6%). During follow‐up, 75.8% were on monotherapy with LEV (56.3%), VPA (25.5%) or brivaracetam (BRV) (8.2%). LEV was discontinued due to irritability in 21.9% of patients (interestingly 48% tolerated BRV after LEV discontinuation).VPA was abandoned in 14% due to motor worsening. Seizure control at one year was achieved in 65.9%, when considering BTCS, but only 30.2% were free of of myoclonic seizures.DiscussionLOMEDs is a very common comorbidity in DSAD that responds partially to treatment. BTCS seem to have a better response to treatment compared to myoclonic seizures.
eHealth interventions for informal caregivers of people with dementia
Authors: Bui Linh Khanh , Park Myonghwa , Giap Thi‐Thanh‐Tinh 
Published: June 2023

AbstractBackgroundInformal caregivers of people with dementia are considered as second invisible patients due to a huge burden from providing care. eHealth interventions are becoming a preferable option with promising impacts, however current studies showed heterogeneous results in terms of the implementation and efficacy of eHealth interventions. This review aims to systematically evaluate the implementation and effectiveness of eHealth interventions for informal caregivers of people with dementia based on existing evidence from systematic reviews.MethodThe review is a systematic review of systematic reviews following the PRISMA statement. A comprehensive search was undertaken in six databases MEDLINE/Ovid, Embase, CINAHL, Web of Science, Cochrane Library and PsycINFO until November 2021. Keywords for searching included dementia, informal caregivers, eHealth, systematic reviews, and meta‐analyses. Two reviewers independently appraised the quality of evidence by AMSTAR II.ResultThe searches resulted in a total of 1684 records, of which 19 systematic reviews covering 97 unique studies were included. There was a moderate overlap of primary studies within included studies, the corrected covered area was 10.3. The quality of included reviews varied from high to critical low according to AMSTAR II. Only two reviews were rated as high quality, five reviews were categorized as moderate, the remaining reviews were rated as low or critical low quality. The eHealth interventions were provided through multiple components covering (1) information, (2) psychoeducation, (3) communication and interaction, (4) psycho‐therapeutic interventions, and (5) psycho‐social support. Interventions were delivered through various technology formats such as the Internet, telephone, and a combination of the Internet, telephone and additionally supplemental modes. Promising evidence about the effectiveness in reducing depression and anxiety for caregivers was extracted. The evidence was quite mixed but generally positive in terms of caregiver burden, stress, self‐efficacy, knowledge and skill improvements; the effect sizes tended to be small. Meanwhile, limited evidence supported the efficacy of eHealth interventions on improving quality of life and coping competence for caregivers.ConclusioneHealth interventions are widely applied and promising. Nevertheless, the lack of high methodological quality across systematic reviews was revealed. Future research should be more rigorous to create robust evidence for this rapidly changing field.
Risk factors of brain atrophy in cognitively normal elderly
Authors: Zhao Lei , Luo Yishan , Mok Vincent C.T. , Liu Jun , Shi Lin ,   for the Alzheimer Disease Neuroimaging Initiative
Published: June 2023

AbstractBackgroundLifestyle‐related risk factors (e.g., smoking) and common health problems (e.g., hypertension) have been found to be associated with brain atrophy. However, it is still not clear about their independent contribution to brain atrophy, especially among the elderly with normal cognition. Here, we aim to identify the independent risk factors of brain atrophy in cognitively normal elderly.MethodWe included 419 elderly subjects with normal cognition (Table 1) from the ADNI database (ADNI1/ADNI2/ADNI‐GO) who had available data of lifestyle‐related risk factors (alcohol abuse, smoking) and common health problems (obesity, hypertension, high cholesterol, high triglycerides, sleep disturbance) and underwent 3D T1‐weighted MRI scans at baseline. The T1‐weighted images were processed with AccuBrain IV2.0 to quantify the brain volumetric measures as listed in Table 2. Univariate analyses were performed with ANCOVA to investigate the influence of the risk factors for each brain volumetric measure, while age, gender, education and APOE4 carrier were covaried out. The independent contribution of the risk factors were further identified by entering them together in a multivariate linear regression model as predictors of brain atrophy using backward elimination.ResultIn the univariate analyses, obesity showed the most widely influence of brain atrophy throughout the brain, followed by hypertension which contributed to atrophy in cerebellum and part of cortical gray matter (GM), alcohol abuse that contributed to atrophy in part of basal ganglia structures, high triglycerides for atrophy of pons and cerebellum, and smoking for medial temporal lobe atrophy (Table 3). When other risk factors were also considered (Table 4), the contribution of obesity to the atrophy of most brain regions remained significant. Hypertension, alcohol abuse and smoking also showed independent contributions (p<0.05) to the atrophy of several brain regions, while sleep disturbance (for brain parenchyma) and high triglycerides (for cerebellum) only presented mild independent contribution (0.05<p<0.10) to brain atrophy.ConclusionObesity presented most independent contribution to brain atrophy in cognitively normal elderly, followed by hypertension, alcohol abuse and smoking. These results may facilitate the interpretation of brain atrophy in normal subjects and intervention of reversible brain atrophy caused by specific risk factors.
Social connection in long‐term care home residents: A review of research on health outcomes and strategies during COVID‐19
Authors: Bethell Jennifer , Aelick Katelynn , Babineau Jessica , Bretzlaff Monica , Edwards Cathleen , Colborne Debbie Hewitt , Iaboni Andrea , Schon Denise , Sommerlad Andrew , McGilton Katherine S 
Published: June 2023

AbstractBackgroundThe infection control measures enacted to prevent COVID‐19 in long‐term care (LTC) homes have highlighted the important role of social connection in the wellbeing and care of people living in these settings. Yet, issues of loneliness and social isolation in LTC home residents pre‐date COVID‐19, as does the research to address them.MethodWe conducted a scoping review of published research that quantified the association of any aspect of social connection among LTC residents with mental health outcomes. We also sought studies of modifiable risk factors and interventions that identified strategies that could be implemented and adapted by LTC residents, families and staff during COVID‐19. We searched eight databases from inception to search date (July 2019), extracted data and conducted a narrative synthesis of evidence. We involved knowledge users representing LTC residents, families and staff in priority‐setting (defining the review questions), analyzing data, interpreting and contextualizing the results, and disseminating the findings. In this presentation, to further characterize the evidence, we compare the measures used in these studies to those identified from an ongoing systematic review of measures developed specifically to assess social connection in people living in LTC homes.ResultWe located 61 studies that reported the association between social connection and mental health outcomes, including depression; responsive behaviors; mood, affect, and emotions; anxiety; medication use; cognitive decline; and, others. We located 72 studies that informed 12 strategies for building and maintaining social connection during COVID‐19; some strategies represented fundamental aspects of resident care whereas others that would need to be considered in context with a LTC resident’s and home’s needs and circumstances.ConclusionOur review identifies a body of research on social connection in LTC that pre‐dates the COVID‐19 pandemic. The evidence points to quality of social connection for residents being associated with better mental health, and we identified strategies that may help to build and maintain social connection in this setting. We found that the studies assessed numerous aspects of social connection, however, only some used measures developed specifically for this population.