bluuebunny/crossref_metadata_2025_split huggingface dataset:
A decade of progress: bibliometric analysis of trends and hotspots in oral microbiome research (2013-2022)
Authors: Li Zhengrui , Fu Rao , Huang Xufeng , Wen Xutao , Zhang Ling 
Published: May 2023

BackgroundOver the past decade, a plethora of studies have delved into the oral microbiome. Our objective was to evaluate the trends in oral microbiome research employing a quantitative approach.Materials and methodsWe extracted clinical studies on the oral microbiome published between 2013 and 2022 from the Web of Science database, yielding 3024 articles. The assembled literature was visually scrutinized using VOSviewer 1.6.18, Citespace 6.1.6, Pajek, Scimago Graphica, and other specialized software to assess authors, institutions, countries, journals, co-cited literature, keywords, genes, and diseases.ResultsOur analysis identified a total of 3024 articles. The volume and rate of annual publications steadily increased, with research interest in the oral microbiome progressively intensifying. The United States, China, and the UK contributed the highest number of publications. Growth rates of publications varied among countries over time. The Forsyth Institute emerged as the most collaborative institution, boasting the highest number of relevant papers (135) and securing the top rank, followed by Sichuan University and Harvard University. Paster Bruce J, Zhou Xuedong, and He Xuesong were pioneers in the field of oral microbiome research. This analysis demonstrates that the homeostatic balance of the oral microbiome, advanced microbial sequencing technology, connections with gut microbiota, and tumorigenesis, including oral cancer, have become emerging topics in the oral microbiome field.ConclusionsThis study delineated a comprehensive landscape of hotspots and frontiers in oral microbiome research, thus facilitating the identification of interdisciplinary advancements. We sincerely hope that our bibliometric analysis will enable researchers to leverage the oral microbiome to ultimately improve human oral health.
Stroke and pump thrombosis following left ventricular assist device implantation: The impact of the implantation technique
Authors: Nozdrzykowski Michal , Bauer Jessica-Marie , Schulz Uwe , Jawad Khalil , Bireta Christian , Eifert Sandra , Sandri Marcus , Jozwiak-Nozdrzykowska Joanna , Borger Michael A. , Saeed Diyar 
Published: May 2023

ObjectivesSeveral studies have shown the potential advantage of less-invasive surgery (LIS) for left ventricular assist device (LVAD) implantation. This study aims to determine the impact of LIS on stroke and pump thrombosis events after LVAD implantation.MethodsBetween January 2015 and March 2021, 335 consecutive patients underwent LVAD implantation using either conventional sternotomy (CS) or the LIS technique. Patient characteristics was prospectively collected. All patients were followed up until October 2021. Logistic multivariate regression and propensity-matched analyses were performed to account for confounding factors.ResultsA total of 242 patients (F = 32; 13.0%) underwent LVAD implantation with CS and 93 patients (F = 8; 8.6%) with the LIS approach. Propensity matching generated two groups, including 98 patients in the CS group and 67 in the LIS group. Intensive care unit stay for the LIS group patients was significantly shorter than that for the CS group patients [2 (IQR: 2–5) days vs. 4 (IQR: 2–12) days, p &lt; 0.01]. There were no significant differences in the incidence of stroke events (14% in CS vs. 16% in the LIS group; p = 0.6) or in pump thrombosis (6.1% in CS vs. 7.5% in the LIS group; p = 0.8) between the groups. The hospital mortality rate in the matched cohort was significantly lower in the LIS group (7.5% vs. 19%; p = 0.03). However, the 1-year mortality rate showed no significant difference between both groups (24.5% in CS and 17.9% in LIS; p = 0.35).ConclusionsThe LIS approach for LVAD implantation is a safe procedure with potential advantage in the early postoperative period. However, the LIS approach remains comparable to the sternotomy approach in terms of postoperative stroke, pump thrombosis, and outcome.
Development and validation of a scale to measure the simulation-based learning outcomes in teacher education
Authors: Levin Orna , Frei-Landau Rivi , Goldberg Chen 
Published: May 2023

IntroductionSimulation-based learning (SBL) is gradually being integrated into the field of teacher education. However, beyond specific content acquisition, comprehensive knowledge of SBL outcomes is limited. This research aimed to systematically develop a scale to measure SBL outcomes in teacher education.MethodsA mixed-methods sequential exploratory design was implemented, to develop the Simulation-based Learning Outcomes in Teacher Education (SLOTE) scale. Data were collected in two phases: a qualitative (N = 518) phase followed by a quantitative (N = 370) phase.ResultsThe qualitative analysis revealed three overarching themes: communication skills, collaborative-learning-related insights, and emotional self-awareness. The scale items were prepared based on key quotes from the qualitative data. To define, quantify, and validate learning outcomes of SBL in teacher education, EFA and CFA were used to test the relationship among 29 items of the scale.DiscussionThe study provides a theoretical conceptualization of SBL’s multifaceted learning outcomes in teacher education. These findings allow for a better understanding of the observers’ role in SBL, suggesting that enacting the simulation is not inherently more emotionally demanding and, consequently, participants in both roles are apt to benefit equally from the experiential learning afforded by the SBL process. Theoretical and practical implications of using SBL in teacher education are discussed.
Secondary school students’ school-related stressors during the coronavirus disease (COVID-19) pandemic in Sabah, Malaysia
Authors: Wider Walton , Chua Bee Seok , Mutang Jasmine Adela , Pan Lee Ching 
Published: May 2023

IntroductionDue to the rapid spread of the COVID-19 pandemic and the disruption of education systems worldwide, secondary schools in Malaysia have shifted to online classes to ensure educational continuity. Therefore, it was necessary to investigate the various effects of the COVID-19 pandemic on secondary school students.MethodsA self-reported survey with closed and open-ended questions was used to collect data involving 1,067 secondary school students from eight schools in Sabah, Malaysia. The participants were mostly male (53.4%), with a mean age of 14.8 (SD = 1.64). The study involved students from various levels/grades, including transition class, forms 1–5, lower six, and upper six.ResultsStudents faced a variety of school-related stressors, including academic failure due to a poor online course; general mental health issues; a poor internet connection; a lack of in-person interaction; a SOP restriction; an inability to focus; too many homework assignments; burnout; becoming lazier; home conditions; and financial difficulties.DiscussionThe implications for classroom practice, policy formulation, and future research are examined.
Abiraterone acetate and prednisone in metastatic castration-resistant prostate cancer: a real-world retrospective study in China
Authors: Liu Min , Yan Jiaqing , Le Kaidi , Li Ying , Xing Nianzeng , Li Guohui 
Published: May 2023

BackgroundThis research work was aimed at evaluating the incidence and risk factors of adverse events (AEs) occurring in patients treated with abiraterone acetate (AA) and prednisone (PDN) outside clinical trials. These associations were assessed regarding the survival outcomes.MethodsThe study included 191 patients aged ≥18 years of confirmed metastatic castration-resistant prostate cancer (mCRPC) between March 2017 and April 2022. AE incidences were descriptively summarized from the whole cohort. Baseline characteristics, safety (treatment-emergent AEs and severe AEs), and efficacy [progression-free survival (PFS)] were analyzed. Multi-variable Cox proportional hazards models were employed to assess the factors linked with PFS.ResultsOverall, the median PFS was 17.16 months (range, 0.5–57.58). Patient baseline prostate-specific antigen (PSA) ≧̸10 ng/ml (p = 0.000), multiple organ metastasis (p = 0.007), hypertension (p = 0.004), and coronary heart disease (p = 0.004) were associated with worse PFS; however, radiotherapy (p = 0.028) was linked to better PFS at univariate analysis in the overall cohort. Baseline multiple organ metastasis, hypertension, and radiotherapy remained statistically significant in multivariable models (p = 0.007, p= 0.005, and p = 0.011, respectively).Incidence of AEs showed increased bilirubin (BIL) (55/191 patients, 28.8%) followed by increased alanine aminotransferase/aspartate aminotransferase (ALT/AST) (48/191 patients, 25.09%). The most common grade 3 AEs were increased ALT (3/191, 1.57%) followed by elevated BIL, hypercholesterolemia, and hypokalemia. Anemia had shorter PFS. There were no unexpected AEs in any patient.ConclusionAA is effective and tolerated in asymptomatic or slightly symptomatic mCRPC in “real-life” setting. The survival outcomes are influenced by multiple organ metastasis, hypertension, and radiotherapy.
Effects of polystyrene microplastics on dechlorane plus bioaccumulation in the thick-shell mussel
Authors: Xu Qiuxia , Peng Xijian , Guo Yuanming , Hao Qing , Hou Yanlin , Yang Chenghu 
Published: May 2023

The combined pollution of microplastics (MPs) and persistent organic pollutants (POPs) have attracted increasing attention from the international community in recent years. MPs can affect the toxicity, bioenrichment rate and bioavailability of POPs through adsorption and other interactions. Dechlorane Plus (DP) is a chlorinated flame retardant and a typical. DPs used mainly in various polymer materials, such as electrical wire and cable coating. The pollutions of MPs and DPs (syn and anti isomers, syn-DP [s-DP] and anti-DP [a-DP]) are ubiquitously present in the environment. However, the effect of MPs on the bioaccumulation of DP has not been reported. In this study, thick-shell mussels (Mytilus coruscus) were exposed to DPs (10 ng/L, DP10), DPs and polystyrene microplastics (PS) (10 ng/L DP +10 μg/L PS, DP10/PS10; 10 ng/LDP+20 μg/L PS, DP10/PS20) for 28 days to investigate the effect of MPs on DPs enrichment. Thick-shell mussels accumulated DPs in the adductor muscle, gill, and gonad showed an increasing trend with time, but the concentration of DPs in the visceral mass does not show a time-dependent manner. The concentration of DPs in the gonads and gills was significantly affected by the concentration of PS (p &lt; 0.05), but there was no significant correlation between the concentration of DPs and the concentration of PS in the adductor muscle and visceral mass (p &gt; 0.05). Moreover, DPs showed selective enrichment of syn-DP in thick-shell mussel tissues, and there was no significant correlation between this result and PS concentration (p &gt; 0.05). These findings provide a new entry point for studying the interaction between microplastics and persistent organic pollutants in marine organisms.
Evaluating the performance of surfactant and charcoal-based cleaning products to effectively remove PAHs from firefighter gear
Authors: Hossain MD Tanjim , Girase Arjunsing G. , Ormond R. Bryan 
Published: May 2023

Firefighters regularly respond to fire scenes where a mixture of chemicals including volatile, semi-volatile, and nonvolatile compounds are present in smoke and soot. Polycyclic aromatic hydrocarbons (PAHs) are common contaminants at fire scenes that may be deposited on the gear and the individual firefighter. Laundering is a common approach for the decontamination of contaminated gear. Surfactants are widely used by firefighters during laundering to remove PAHs as they are generally non-toxic and biodegradable. The removal of PAHs depends on the surfactant types, chemistries, and concentrations. This study evaluated the effect of surfactant concentrations to remove persistent contaminants like PAHs from turnout gear. The cleaning performance of different types of surfactants was also evaluated. Outer shell fabrics were contaminated with a standard mixture of 16 PAH compounds, and two commercial detergents were used at different concentrations. Additionally, the cleaning efficacy of eight commercially available regular and charcoal-based cleaning products was also determined against PAHs at a single surfactant concentration. For the decontamination method, a bench-scale washing procedure simulating the National Fire Protection Assocation 1851 laundering process was used. The removal efficacy of high molecular weight (HMW) PAHs were found to be lower compared to the low molecular weight PAHs for any type or any concentration of detergent. Our research also showed that the recommended surfactant concentrations provided by detergent manufacturers can be ineffective at removing the HMW PAHs from heavily contaminated fabric. With 1 mL of detergent in a 100-mL bath, which is multiple times higher than recommended amount, only 40% of HMW PAHs were removed. The cleaning efficacy can be increased to above 90% by using higher concentrations of detergents. This research shows that firefighters may need to use a higher concentration of detergent than the recommended amount to effectively remove PAHs from the gear. All the regular and charcoal-based detergents were able to remove PAHs effectively from contaminated fabrics when a higher concentration of detergent was used.
Micro milling of fused silica using picosecond laser shaped single crystal diamond tools
Authors: Song Jiacheng , Tong Zhen , Yao Zhenqiang , Jiang Xiangqian 
Published: May 2023

Fused silica is widely used as a material for optical lenses owing to its excellent optical properties and low thermal expansion coefficient. However, as a hard and brittle material, there is very limited option of processing technologies to machining fused silica with surface structures. In this paper, a picosecond laser based single crystal diamond tool fabrication technology is proposed to generate micro milling tools with different geometrical designs, and the tool cutting performance is experimentally tested through micro-milling of fused silica under different cutting conditions. An optimal picosecond laser processing path is proposed to inhibit the graphitization of diamond tool and improve the concentricity of tool blades, and a multi-edge milling tool with a minimum rotary diameter of 0.4 mm can be obtained. The effects of rake angle on cutting force and the degree of brittle damage on the subsurface of fused silica are studied by micro milling tests of fused silica using the laser-shaped tools. The results show that the fused silica machined by diamond milling tool with a rake angle of −30° has the best surface finish (Ra = 41.2 nm). Using this laser-machined milling tool, a plurality of micro Fresnel lenses with aperture of 1.6 mm were successfully machined on a fused silica sheet.
Prevalence and pattern of multimorbidity among chronic kidney disease patients: a community study in chronic kidney disease hotspot area of Eastern India
Authors: Palo Subrata Kumar , Nayak Soumya Ranjan , Sahoo Debadutta , Nayak Swetalina , Mohapatra Ashis Kumar , Sahoo Aviram , Dash Pujarini , Pati Sanghamitra 
Published: May 2023

IntroductionChronic kidney disease (CKD) is mostly asymptomatic until reaching an advanced stage. Although conditions such as hypertension and diabetes can cause it, CKD can itself lead to secondary hypertension and cardiovascular disease (CVD). Understanding the types and prevalence of associated chronic conditions among CKD patient could help improve screening for early detection and case management.MethodsA cross sectional study of 252 CKD patients in Cuttack, Odisha (from the last 4 years CKD data base) was telephonically carried out using a validated Multimorbidity Assessment Questionnaire for Primary Care (MAQ-PC) tool with the help of an android Open Data Kit (ODK). Univariate descriptive analysis was done to determine the socio-demographic distribution of CKD patients. A Cramer’s heat map was generated for showing Cramer’s coefficient value of association of each diseases.ResultsThe mean age of participants was 54.11 (±11.5) years and 83.7% were male. Among the participants, 92.9% had chronic conditions (24.2% with one, 26.2% with two and 42.5% with three or more chronic conditions). Most prevalent chronic conditions were hypertension (48.4%), peptic ulcer disease (29.4%), osteoarthritis (27.8%) and diabetes (13.1%). Hypertension and osteoarthritis were found to be most commonly associated (Cramer’s V coefficient = 0.3).ConclusionIncreased vulnerability to chronic conditions among CKD patients make them at higher risk for mortality and compromised quality of life. Regular screening of CKD patient for other chronic conditions (hypertension, diabetes, peptic ulcer disease, osteoarthritis and heart diseases) would help in detecting them early and undertake prompt management. The existing national program could be leveraged to achieve this.
Sex differences in the genetics of sarcoidosis across European and African ancestry populations
Authors: Xiong Ying , Kullberg Susanna , Garman Lori , Pezant Nathan , Ellinghaus David , Vasila Vasiliki , Eklund Anders , Rybicki Benjamin A. , Iannuzzi Michael C. , Schreiber Stefan , Müller-Quernheim Joachim , Montgomery Courtney G. , Grunewald Johan , Padyukov Leonid , Rivera Natalia V. 
Published: May 2023

BackgroundSex differences in the susceptibility of sarcoidosis are unknown. The study aims to identify sex-dependent genetic variations in two clinical sarcoidosis phenotypes: Löfgren’s syndrome (LS) and non-Löfgren’s syndrome (non-LS).MethodsA meta-analysis of genome-wide association studies was conducted on Europeans and African Americans, totaling 10,103 individuals from three population-based cohorts, Sweden (n = 3,843), Germany (n = 3,342), and the United States (n = 2,918), followed by an SNP lookup in the UK Biobank (UKB, n = 387,945). A genome-wide association study based on Immunochip data consisting of 141,000 single nucleotide polymorphisms (SNPs) was conducted in the sex groups. The association test was based on logistic regression using the additive model in LS and non-LS sex groups independently. Additionally, gene-based analysis, gene expression, expression quantitative trait loci (eQTL) mapping, and pathway analysis were performed to discover functionally relevant mechanisms related to sarcoidosis and biological sex.ResultsWe identified sex-dependent genetic variations in LS and non-LS sex groups. Genetic findings in LS sex groups were explicitly located in the extended Major Histocompatibility Complex (xMHC). In non-LS, genetic differences in the sex groups were primarily located in the MHC class II subregion and ANXA11. Gene-based analysis and eQTL enrichment revealed distinct sex-specific gene expression patterns in various tissues and immune cell types. In LS sex groups, a pathway map related to antigen presentation machinery by IFN-gamma. In non-LS, pathway maps related to immune response lectin-induced complement pathway in males and related to maturation and migration of dendritic cells in skin sensitization in females were identified.ConclusionOur findings provide new evidence for a sex bias underlying sarcoidosis genetic architecture, particularly in clinical phenotypes LS and non-LS. Biological sex likely plays a role in disease mechanisms in sarcoidosis.
Development and validation of an electronic database-based frailty index to predict mortality and hospitalization in a population-based study of adults with SARS-CoV-2
Authors: Rebora Paola , Scirè Carlo Alberto , Occhino Giuseppe , Bortolan Francesco , Leoni Olivia , Cideni Francesco , Zucchelli Alberto , Focà Emanuele , Marengoni Alessandra , Bellelli Giuseppe , Valsecchi Maria Grazia 
Published: May 2023

BackgroundElectronic health databases are used to identify people at risk of poor outcomes. Using electronic regional health databases (e-RHD), we aimed to develop and validate a frailty index (FI), compare it with a clinically based FI, and assess its association with health outcomes in community-dwellers with SARS-CoV-2.MethodsData retrieved from the Lombardy e-RHD were used to develop a 40-item FI (e-RHD-FI) in adults (i.e., aged ≥18 years) with a positive nasopharyngeal swab polymerase chain reaction test for SARS-CoV-2 by May 20, 2021. The considered deficits referred to the health status before SARS-CoV-2. The e-RHD-FI was validated against a clinically based FI (c-FI) obtained from a cohort of people hospitalized with COVID-19 and in-hospital mortality was evaluated. e-RHD-FI performance was evaluated to predict 30-day mortality, hospitalization, and 60-day COVID-19 WHO clinical progression scale, in Regional Health System beneficiaries with SARS-CoV-2.ResultsWe calculated the e-RHD-FI in 689,197 adults (51.9% females, median age 52 years). On the clinical cohort, e-RHD-FI correlated with c-FI and was significantly associated with in-hospital mortality. In a multivariable Cox model, adjusted for confounders, each 0.1-point increment of e-RHD-FI was associated with increased 30-day mortality (Hazard Ratio, HR 1.45, 99% Confidence Intervals, CI: 1.42–1.47), 30-day hospitalization (HR per 0.1-point increment = 1.47, 99%CI: 1.46–1.49), and WHO clinical progression scale (Odds Ratio = 1.84 of deteriorating by one category, 99%CI 1.80–1.87).ConclusionThe e-RHD-FI can predict 30-day mortality, 30-day hospitalization, and WHO clinical progression scale in a large population of community-dwellers with SARS-CoV-2 test positivity. Our findings support the need to assess frailty with e-RHD.
Clinical Pharmacy Faculty Provision of Direct Patient Care, Challenges, and Opportunities
Authors: Korayem Ghazwa B. , Alqahtani Lama Ali , Alsulaiman Sultanah Hisham , Alhammad Abdullah M. , Badreldin Hisham A. , Alkhudair Nora , Al Sulaiman Khalid , Aljuhani Ohoud 
Published: May 2023

BackgroundThe quadripartite mission of clinical track faculty members involves research, teaching, services, and direct patient care. However, the extent of faculty involvement in direct patient care remains a challenge. Thus, the study’s objective is to evaluate the effort spent on direct patient care by clinical faculty of pharmacy schools in Saudi Arabia (S.A.) and identify factors that hinder or facilitate providing direct patient care services.MethodsThis multi-institutional, cross-sectional questionnaire study conducted between July 2021 and March 2022 involved several pharmacy schools’ clinical pharmacy faculty members in S.A. The primary outcome was the percentage of time/effort spent on patient care services and other academic responsibilities. The secondary outcomes were the factors affecting the effort spent on direct patient care and the barriers preventing the provision of clinical services.ResultsA total of 44 faculty members took the survey. The percentage of effort spent on clinical education was highest at a median (IQR) of 37.5 (30, 50), followed by that spent on patient care [19 (10, 28.75)]. The percentages of effort spent on education and the length of academic experience were negatively associated with efforts spent on direct patient care. The most commonly reported barrier affecting fulfilling patient care duties was the lack of a clear practice policy (68%).ConclusionAlthough most clinical pharmacy faculty members were involved in direct patient care, half of them devoted only 20% or less of their time to it. An effective effort allocation for clinical faculty duties will require the development of a clinical faculty workload model that sets realistic expectations about the time spent on clinical and non-clinical duties.