bluuebunny/crossref_metadata_2025_split huggingface dataset:
Valuing options to renew at future market value: the case of commercial property leases
Authors: Wang Jenny Jing , Shen Jianfu , Pretorius Frederik 
Published: April 2023

AbstractIn this study, we develop and empirically test a valuation model for a commonly encountered option in office leases: a tenant’s option to renew at future market rent (a fair market value) with lease termination as the maturity date. The model integrates decision analysis with real options analysis and market risk with private risks. “Option value” is defined as the private value of the option to either party pre-contract, while “option price” assumes a fair agreement between transacting parties and can be positive (rental premium paid) or negative (rental discount offered). Without manifest expectations, an analysis of a sample of office leases supports the model’s logic with price estimates in a practical range. The tenants’ option price/value is shown to have a negative relationship with the original/renewal lease term; conversely, the landlords’ option value is positively related to the original/renewal term. Comparative analyses show that transaction costs have a positive effect on tenants’ option value and on prices, while vacancy costs and the vacancy period are both positively related to the landlords’ option value and negatively related to price. Market rent is found to have a negative relationship with option price. Overall, this study provides a theoretical analysis and empirical tests of the value of a real option that allows option holders to renew/extend their contracts at a fair market value.
Quail on fire: changing fire regimes may benefit mountain quail in fire-adapted forests
Authors: Brunk Kristin M. , Gutiérrez R. J. , Peery M. Zachariah , Cansler C. Alina , Kahl Stefan , Wood Connor M. 
Published: April 2023

Abstract
Background
Fire-adapted forests in western North America are experiencing rapid changes to fire regimes that are outside the range of historic norms. Some habitat-specialist species have been negatively impacted by increases in large, high-severity fire, yet, the responses of many species to fire, especially at longer time scales, remain ambiguous. We studied the response of a widely distributed species, the mountain quail (Oreortyx pictus), to wildfire across the Sierra Nevada of California, because its habitat selection patterns provided an opportunity to evaluate potentially contrasting responses among habitat specialists.

Results
We used passive acoustic monitoring across > 22,000 km2 of the Sierra Nevada and Bayesian hierarchical occupancy modeling to conduct the first study of the effects of habitat, fire severity, and time since fire (1–35 years) on the occupancy of a little-understood management indicator species, the mountain quail. Mountain quail responded positively to high-severity fire and neutrally to low-moderate-severity fire. Occupancy of quail peaked 6–10 years after high-severity fire and remained high even 11–35 years after an area burned at high severity.

Conclusions
Our work demonstrates that high-severity fire is strongly and positively related to mountain quail occupancy, which is a markedly different response than previously studied species that are also of management concern in the Sierra Nevada. Taken together, our results suggest that mountain quail may actually be “winners” in the face of altered fire regimes in the Sierra Nevada. Given the forecasted intensification of large, severe wildfires in many fire-adapted forests, understanding the ecology and nuanced fire responses of species beyond those that have been historically considered is an important and time-sensitive effort. The relationship between mountain quail and high-severity fire is a reminder that there will be both winners and losers as the dynamics of wildfire change in the era of climate change.
Microdeletion at ESR1 Intron 6 (DEL_6_75504) Is a Susceptibility Factor for Cryptorchidism and Hypospadias
Authors: Masunaga Yohei , Fujisawa Yasuko , Massart Francesco , Spinelli Claudio , Kojima Yoshiyuki , Mizuno Kentaro , Hayashi Yutaro , Sasagawa Isoji , Yoshida Rie , Kato Fumiko , Fukami Maki , Kamatani Naoyuki , Saitsu Hirotomo , Ogata Tsutomu 
Published: April 2023

Abstract

Context
We have previously reported that a specific “AGATC” haplotype in a &gt;34 kb tight linkage disequilibrium (LD) block within ESR1 is strongly associated with cryptorchidism and hypospadias in Japanese boys.

Objective
We aimed to determine the true susceptibility factor for cryptorchidism and hypospadias linked to the “AGATC” haplotype.

Methods
We performed various molecular studies in hitherto unreported 230 Italian boys (80 with cryptorchidism and 150 with normal genitalia) and previously reported and newly recruited 415 Japanese boys (149 with cryptorchidism, 141 with hypospadias, and 125 with normal genitalia). We also performed ESR1 expression analyses using breast cancer–derived MCF-7 cells.

Results
Haplotype analysis revealed the LD block and positive association of the “AGATC” haplotype with cryptorchidism in Italian boys. Whole genome sequencing identified an identical 2249-bp microdeletion (ΔESR1) generated by a microhomology-mediated replication error in both Japanese and Italian boys with the specific haplotype. ΔESR1 was found to be strongly associated with cryptorchidism and hypospadias by Cochran-Armitage trend test and was revealed to show nearly absolute LD with the “AGATC” haplotype. ESR1 expression was upregulated in MCF-7 cells with a homozygous deletion encompassing ΔESR1 and those with a homozygous deletion involving a CTCF-binding site within ΔESR1.

Conclusion
The results reveal that ΔESR1, which has been registered as “DEL_6_75504” in gnomAD SVs v2.1, is the true susceptibility factor for cryptorchidism and hypospadias. It appears that ΔESR1 was produced in a single ancestral founder of modern humans and has been maintained within the genome of multiple ethnic groups by selection.
Clinical Impact and Predictors of Aneurysmal Rebleeding in Poor-Grade Subarachnoid Hemorrhage: Results From the National POGASH Registry
Authors: Panni Pietro , Riccio Lucia , Cao Roberta , Pedicelli Alessandro , Marchese Enrico , Caricato Anselmo , Feletti Alberto , Testa Mattia , Zanatta Paolo , Gitti Nicola , Piva Simone , Mardighian Dikran , Semeraro Vittorio , Nardin Giordano , Lozupone Emilio , Paiano Giafranco , Picetti Edoardo , Montanaro Vito , Petranca Massimo , Bortolotti Carlo , Scibilia Antonino , Cirillo Luigi , Lanterna Andrea Luigi , Ambrosi Alessandro , Mortini Pietro , Beretta Luigi , Falini Andrea 
Published: April 2023

BACKGROUND:
Scarce data are available regarding rebleeding predictors in poor-grade aneurysmal subarachnoid hemorrhage (aSAH).

OBJECTIVES:
To investigate predictors and clinical impact of rebleeding in a national multicentric poor-grade aSAH.

METHODS:
Retrospective analysis of prospectively collected data from the multicentric Poor Grade Aneurysmal Subarachnoid Hemorrhage Study Group (POGASH) registry of consecutive patients treated from January 1, 2015, to June 30th, 2021. Grading was defined as pretreatment World Federation of Neurological Surgeons grading scale IV-V. Ultra-early vasospasm (UEV) was defined as luminal narrowing of intracranial arteries not due to intrinsic disease. Rebleeding was defined as clinical deterioration with evidence of increased hemorrhage on subsequent computed tomography scans, fresh blood from the external ventricular drain, or deterioration before neuroradiological evaluation. Outcome was assessed by the modified Rankin Scale.

RESULTS:
Among 443 consecutive World Federation of Neurological Surgeons grades IV-V patients with aSAH treated within a median of 5 (IQR 4-9) hours since onset, rebleeding occurred in 78 (17.6%). UEV (adjusted odds ratio [OR] 6.8, 95% CI 3.2-14.4; P < .001) and presence of dissecting aneurysm (adjusted OR 3.5, 95% CI 1.3-9.3; P = .011) independently predicted rebleeding while history of hypertension (adjusted OR 0.4, 95% CI 0.2-0.8; P = .011) independently reduced its chances. 143 (32.3) patients died during hospitalization. Rebleeding emerged, among others, as an independent predictor of intrahospital mortality (adjusted OR 2.2, 95% CI 1.2-4.1; P = .009).

CONCLUSION:
UEV and presence of dissecting aneurysms are the strongest predictors of aneurysmal rebleeding. Their presence should be carefully evaluated in the acute management of poor-grade aSAH.
Association of Sit-to-Stand Capacity and Free-Living Performance Using Thigh-Worn Accelerometers among 60- to 90-Yr-Old Adults
Authors: LÖPPÖNEN ANTTI , DELECLUSE CHRISTOPHE , SUORSA KRISTIN , KARAVIRTA LAURA , LESKINEN TUIJA , MEULEMANS LIEN , PORTEGIJS ERJA , FINNI TAIJA , RANTANEN TAINA , STENHOLM SARI , RANTALAINEN TIMO , VAN ROIE EVELIEN 
Published: April 2023

ABSTRACT

Purpose
Five times sit-to-stand (STS) test is commonly used as a clinical assessment of lower-extremity functional ability, but its association with free-living performance has not been studied. Therefore, we investigated the association between laboratory-based STS capacity and free-living STS performance using accelerometry. The results were stratified according to age and functional ability groups.

Methods
This cross-sectional study included 497 participants (63% women) 60–90 yr old from three independent studies. A thigh-worn triaxial accelerometer was used to estimate angular velocity in maximal laboratory-based STS capacity and in free-living STS transitions over 3–7 d of continuous monitoring. Functional ability was assessed with short physical performance battery.

Results
Laboratory-based STS capacity was moderately associated with the free-living mean and maximal STS performance (r = 0.52–0.65, P < 0.01). Angular velocity was lower in older compared with younger and in low- versus high-functioning groups, in both capacity and free-living STS variables (all P < 0.05). Overall, angular velocity was higher in capacity compared with free-living STS performance. The STS reserve (test capacity − free-living maximal performance) was larger in younger and in high-functioning groups compared with older and low-functioning groups (all P < 0.05).

Conclusions
Laboratory-based STS capacity and free-living performance were found to be associated. However, capacity and performance are not interchangeable but rather provide complementary information. Older and low-functioning individuals seemed to perform free-living STS movements at a higher percentage of their maximal capacity compared with younger and high-functioning individuals. Therefore, we postulate that low capacity may limit free-living performance.
Resistance Training for Older Women: Do Adaptive Responses Support the ACSM and NSCA Position Stands?
Authors: CAVALCANTE EDILAINE F. , KASSIANO WITALO , RIBEIRO ALEX S. , COSTA BRUNA , CYRINO LETÍCIA T. , CUNHA PAOLO M. , ANTUNES MELISSA , SANTOS LEANDRO DOS , TOMELERI CRISIELI M. , NABUCO HELLEN C. G. , SUGIHARA-JÚNIOR PAULO , FERNANDES RODRIGO R. , RODRIGUES RICARDO J. , CARNEIRO MARCELO A. S. , PINA FÁBIO L. C. , DIB MÁRCIA M. , TEIXEIRA DENILSON C. , ORSATTI FÁBIO L. , VENTURINI DANIELLE , BARBOSA DÉCIO S. , CYRINO EDILSON S. 
Published: April 2023

ABSTRACT

Purpose
The optimal intensity of resistance training (RT) to improve muscular, physical performance, and metabolic adaptations still needs to be well established for older adults. Based on current position statements, we compared the effects of two different RT loads on muscular strength, functional performance, skeletal muscle mass, hydration status, and metabolic biomarkers in older women.

Methods
One hundred one older women were randomly allocated to perform a 12-wk whole-body RT program (eight exercises, three sets, three nonconsecutive days a week) into two groups: 8–12 repetitions maximum (RM) and 10–15RM. Muscular strength (1RM tests), physical performance (motor tests), skeletal muscle mass (dual-energy X-ray absorptiometry), hydration status (bioelectrical impedance), and metabolic biomarkers (glucose, total cholesterol, HDL-c, HDL-c, triglycerides, and C-reactive protein) were measured at baseline and posttraining.

Results
Regarding muscular strength, 8–12RM promoted higher 1RM increases in chest press (+23.2% vs +10.7%, P < 0.01) and preacher curl (+15.7% vs +7.4%, P < 0.01), but not in leg extension (+14.9% vs +12.3%, P > 0.05). Both groups improved functional performance (P < 0.05) in gait speed (4.6%–5.6%), 30 s chair stand (4.6%–5.9%), and 6 min walking (6.7%–7.0%) tests, with no between-group differences (P > 0.05). The 10–15RM group elicited superior improves in the hydration status (total body water, intracellular and extracellular water; P < 0.01), and higher gains of skeletal muscle mass (2.5% vs 6.3%, P < 0.01), upper (3.9% vs 9.0%, P < 0.01) and lower limbs lean soft tissue (2.1% vs 5.4%, P < 0.01). Both groups improved their metabolic profile. However, 10–15RM elicited greater glucose reductions (−0.2% vs −4.9%, P < 0.05) and greater HDL-c increases (−0.2% vs +4.7%, P < 0.01), with no between-group differences for the other metabolic biomarkers (P > 0.05).

Conclusions
Our results suggest that 8–2RM seems more effective than 10–15RM for increasing upper limbs’ muscular strength, whereas the adaptative responses for lower limbs and functional performance appear similar in older women. In contrast, 10–15RM seems more effective for skeletal muscle mass gains, and increased intracellular hydration and improvements in metabolic profile may accompany this adaptation.
Mutation patterns of resistance genes for macrolides, aminoglycosides, and rifampicin in non-tuberculous mycobacteria isolates from Kenya
Authors: Mwangi Zakayo , Naeku Grace , Mureithi Marianne , Onyambu Frank , Bulimo Wallace 
Published: April 2023

Background: Non-tuberculous mycobacteria (NTM) treatment constitutes a macrolide-based antibiotic regimen in combination with aminoglycosides for Rapid-Growing Mycobacteria (RGM), and rifampicin for Slow-Growing Mycobacteria (SGM). Mutations in the anti-NTM drug target regions promote NTM evolution to mutant strains that are insusceptible to NTM drugs leading to treatment failure. We, therefore, described the mutation patterns of anti-NTM drug target genes including rrl, rrs, and rpoB in NTM isolates from Kenya. Methods: We carried out a cross-sectional study that included 122 NTM obtained from the sputum of symptomatic tuberculosis-negative patients in Kenya. All 122 NTM underwent targeted sequencing of the rrl gene. The 54 RGM were also sequenced for rrs, and the 68 SGM were sequenced for rpoB genes using ABI 3730XL analyzer. The obtained sequences were aligned to their wild-type reference sequences for each gene using Geneious then mutations were identified. Pearson chi-square at a 95% confidence interval tested the association of NTM to mutation patterns for each gene. Results: NTM harboring mutations associated with resistance to at least one of the antibiotics used in the macrolide-based therapy were 23% (28/122). Of these NTM, 10.4% (12/122) had mutations in the rrl gene with 58.3% (7/12) comprising RGM and 41.7% (5/12) being SGM. Mutation at position 2058 (A2058G, A2058C, A2058T) of the rrl gene was seen for 83.3% (10/12) of NTM, while 16.6% (2/12) harbored a A2059G mutation. Of the 54 RGM included for rrs characterization, 11.1% (6/54) exhibited mutations at position 1408(A1408G), while 14.7% (10/68) of the SGM had mutations in the rpoB gene at positions S531W, S531L, S531Y, F506L, E509H with M.gastri having multiple mutations at positions D516V, H526D and, S531F. Conclusion: We demonstrated a significant level of mutations associated with drug resistance for macrolides, aminoglycosides, and rifampicin in NTM isolated from symptomatic TB negative patients in Kenya.
Predicting infection with COVID-19 disease using logistic regression model in Karak City, Jordan
Authors: Khaleel Anas , Abu Dayyih Wael , AlTamimi Lina , Dalaeen Liana , Zakaraya Zainab , Ahmad Alhareth , Albadareen Baker , Elbakkoush Abdallah Ahmed 
Published: April 2023

Background: On March 2020, World Health Organization (WHO) labeled coronavirus disease 2019 (COVID-19) as a pandemic. COVID-19 has rapidly increased in Jordan which resulted in the announcement of the emergency state on March 19th, 2020. Despite the variety of research being reported, there is no agreement on the variables that predict COVID-19 infection. This study aimed to test the predictors that probably contributed to the infection with COVID-19 using a binary logistic regression model. Methods: Based on data collected by Google sheet of COVID-19 infected and non-infected persons in Karak city, analysis was applied to predict COVID-19 infection probability using a binary logistic regression model. Results: A total of 386 participants have completed the questionnaire including 323 women and 63 men. Among the participants 295 (76.4%) were aged less than or equal 45 years old, and 91 (23.6%) were aged over 45 years old. Among the 386 participants a total of 275 were infected with COVID-19. The LR chi-square test was used to analyze every demographic characteristic (sex, age, job, smoking, chronic disease, yearly flu injection) in this study to find predictors of the likelihood of COVID-19 infection. The findings indicate that the participants' sex and age are the most important demographic determinants of infection. Cox & Snell R Square (R2 = 0.028) and Nagelkerke R Square (R2 = 0.039) indicators was used to measure model fineness with significant P-value < 0.05. Conclusions: Given a person's age and sex, the final model presented in this study can be used to calculate the probability of infection with COVID-19 in Karak city. This could help aid health-care management and policymakers in properly planning and allocating health-care resources.
Magico-religious beliefs, stigma and help-seeking for adolescent mental health at the community level – A multi-stakeholder qualitative exploration in southern India
Authors: Prabhu Vidya , Chandra Varalakshmi , Ashok Lena , D'Souza Brayal , Nair Ravichandran 
Published: April 2023

Background: Almost half of all mental health disorders begin before the age of 14. However, several barriers exist to seeking help for mental health conditions among adolescents in the Indian context. The present study aimed at exploring multi-stakeholder perspectives on adolescent mental health and help-seeking behavior as well as referral. Methods: Our study adopted a qualitative design with focus group discussions (FGDs) and in-depth interviews (IDIs) conducted over a span of one year among 70 participants using purposive sampling. Participants included parents of adolescents, adolescents aged 14–16 years, high school teachers, and mental health professionals (MHP) and a pediatrician. The study was conducted in selected educational blocks of Udupi taluk. Parental written informed consent and assent from adolescents were obtained. Data was transcribed and thematic analysis was performed using Atlas.ti (version 8) to identify codes and code families following which themes were identified. Results: Our findings elicited community-held beliefs and attitudes indicating pathways and barriers to seeking care. Participants perceived that increased device use, accessing pornographic material, experiencing bullying, academic stress and negative perceptions surrounding mental health with the addition of magico-religious beliefs contributed to delayed help-seeking. Barriers to help-seeking included stigmatizing cultural perceptions. A considerable proportion of families found traditional healing more acceptable in the community. Conclusions: Stigma related to mental health continues to be one of the major barriers to early intervention. School counselors, teachers and even religious leaders in the community were found as effective liaisons in providing referrals to MHP. Recommendations for future studies and the way forward are discussed.
APPLICATION OF GAMIFICATION TOOLS IN THE PROCESS OF TRAINING AND DEVELOPMENT OF THE PERSONNEL RESERVE
Authors: Kashtanova YEkatyerina , Zhgutova E. 
Published: April 2023

The article discusses the concept of gamification in personnel management, provides examples of the use of gamification in various processes of personnel management in the organization, defines the role of gamification in the system of personnel training and development. The characteristics of the main gamification tools that can be used in the process of personnel training, in particular in the process of working with the personnel reserve, are given. As an example of using gamification, the authors describe the architecture of a mobile application for training and development of the personnel reserve, which contains most of the gamification tools considered.
THE IMPACT OF GLOBAL DIGITALIZATION ON THE STRUCTURE OF THE WORLD AND NATIONAL LABOR MARKETS
Authors: Svistunov V. , Lobachyev V. 
Published: April 2023

The purpose of this article is a meaningful analysis of modern features and trends of the world and domestic labor markets in the conditions of total digitalization. The processes of active development and large­scale introduction of digital technologies today are a global trend for almost all countries of the world. At the same time, according to expert opinion, serious technological and economic development based on the processes of digitalization cannot but have a significant impact on the structural changes taking place both in the global and national labor markets. What are the current features of the changes taking place in the labor markets? What are the prospects for professional labor markets? The answers to these questions are more exciting than ever today for both business owners and HR specialists.
Therapeutic strategy in the form of communication in the children with the autism spectrum disorders - narrative review
Authors: Nowak Dominika , Próchnicka Magdalena , Siwek Michał , Giermasiński Adrian , Tuszyńska Weronika , Zarzycki Adam , Komisarczuk Mateusz 
Published: April 2023

Autism spectrum disorders (ASD) is a neurodevelopmental disorder influenced by a number of genetic and environmental factors. It is characterized by a broad range of symptoms, particularly in the areas of communication and language, which pose a therapeutic challenge for both parents and therapists.

This article, based on a review of available studies on PubMed, presents therapeutic methods based on functional communication strategies and ways to implement them as a form of treatment for children with the autism spectrum disorders.

The major goals of ASD treatment are socialization and communication skills improvement and current treatments are not based on pharmacological therapies, but on behavioral therapies. Through appropriate speech development and practical communication strategies that are based on techniques like motivating the child to create eye contact with an adult, it is possible to realize the development of proper communication. These strategies are a form of therapy and allow for the improvement of the child's communication on multiple levels and shaping the social attitudes. Incorporating suitable therapeutic communication techniques enables the development and enhancement of social skills in children with autism spectrum disorders. Children with ASD benefit from appropriate communication because it helps them communicate their needs, understand the social norms, and improve their quality of life.
Management of Guidewire Entrapment and Fracture During Percutaneous Coronary Intervention: When All Bailout Techniques Fail!
Authors: Sharma Tushar , Pfeffer Brad , Kwon Christopher C. , Damluji Abdulla A. 
Published: April 2023

Abstract
A 55-year-old man presented with chest pain and was diagnosed with non–ST-segment elevation myocardial infarction. Coronary angiography revealed a 95% eccentric lesion in the mid-right coronary artery. After 3 intracoronary stents were placed, the guidewire became entrapped in 1 of the stents; multiple attempts at retrieval were unsuccessful. Ultimately, the guidewire fractured, and a coronary artery bypass graft surgery was performed to remove the guidewire fragments. This report reviews the procedural steps for wire retrieval that are critical for operators to avoid coronary artery bypass surgery.