bluuebunny/crossref_metadata_2025_split huggingface dataset:
Subtype-selective agonists of plant hormone co-receptor COI1-JAZs identified from the stereoisomers of coronatine
Authors: Hayashi Kengo , Kato Nobuki , Bashir Khurram , Nomoto Haruna , Nakayama Misuzu , Chini Andrea , Takahashi Satoshi , Saito Hiroaki , Watanabe Raku , Takaoka Yousuke , Tanaka Maho , Nagano Atsushi J. , Seki Motoaki , Solano Roberto , Ueda Minoru 
Published: March 2023

AbstractSevere genetic redundancy is particularly clear in gene families encoding plant hormone receptors, each subtype sharing redundant and specific functions. Genetic redundancy of receptor family members represents a major challenge for the functional dissection of each receptor subtype. A paradigmatic example is the perception of the hormone (+)-7-iso-jasmonoyl-L-isoleucine, perceived by several COI1-JAZ complexes; the specific role of each receptor subtype still remains elusive. Subtype-selective agonists of the receptor are valuable tools for analyzing the responses regulated by individual receptor subtypes. We constructed a stereoisomer library consisting of all stereochemical isomers of coronatine (COR), a mimic of the plant hormone (+)-7-iso-jasmonoyl-L-isoleucine, to identify subtype-selective agonists for COI1-JAZ co-receptors in Arabidopsis thaliana and Solanum lycopersicum. An agonist selective for the Arabidopsis COI1-JAZ9 co-receptor efficiently revealed that JAZ9 is not involved in most of the gene downregulation caused by COR, and the degradation of JAZ9-induced defense without inhibiting growth.
Electrical conductivity and nuclear magnetic resonance relaxation rate of Eliashberg superconductors in the weak-coupling limit
Authors: Boyack Rufus , Mirabi Sepideh , Marsiglio F. 
Published: March 2023

AbstractElectrical conductivity is an important transport response in superconductors, enabling clear signatures of dynamical interactions to be observed. Of primary interest in this paper is to study characteristics of the electron-phonon interaction in weak-coupling Eliashberg theory (Eth), and to note the distinctions with Bardeen-Cooper-Schrieffer (BCS) theory. Recent analysis of weak-coupling Eth has shown that while there are modifications from the BCS results, certain dimensionless ratios are in agreement. Here we show that the conductivities in BCS theory and Eth fundamentally differ, with the latter having an imaginary gap component that damps a divergence. We focus on the dirty limit, and for both BCS theory and Eth we derive expressions for the low-frequency limit of the real conductivity. For Eth specifically, there are two limits to consider, depending on the relative size of the frequency and the imaginary part of the gap. In the case of identically zero frequency, we derive an analytical expression for the nuclear magnetic resonance relaxation rate. Our analysis of the conductivity complements the previous study of the Meissner response and provides a thorough understanding of weak-coupling Eth.
Dense geophysical observations reveal a triggered, concurrent multi-fault rupture at the Mendocino Triple Junction
Authors: Yeck William L. , Shelly David R. , Materna Kathryn Z. , Goldberg Dara E. , Earle Paul S. 
Published: March 2023

AbstractA central question of earthquake science is how far ruptures can jump from one fault to another, because cascading ruptures can increase the shaking of a seismic event. Earthquake science relies on earthquake catalogs and therefore how complex ruptures get documented and cataloged has important implications. Recent investments in geophysical instrumentation allow us to resolve increasingly complex, multi-fault ruptures for even moderate-sized earthquakes. We combine dense seismic and geodetic measurements to reveal an enigmatic rupture in late 2021 at the Mendocino Triple Junction in northern California. We show that rupture was dynamically triggered, yet concurrent, on two distinct faults roughly 30 km apart. Thus, this rupture combines features of complex ruptures usually considered to be single earthquakes, and triggered ruptures considered as multiple earthquakes. This event illustrates that moderate-sized earthquakes can exhibit similar complexity to that more commonly documented for large earthquakes.
Suspension of oral hygiene practices highlights key bacterial shifts in saliva, tongue, and tooth plaque during gingival inflammation and resolution
Authors: Hall Michael William , Wellappuli Nimali Chandhema , Huang Ruo Chen , Wu Kay , Lam David King , Glogauer Michael , Beiko Robert Gerald , Senadheera Dilani Braziunas 
Published: March 2023

Abstract
Experimentally induced gingivitis is associated with inflammatory and microbiological changes in an otherwise healthy subject, demonstrating the impacts of discontinuing oral hygiene routines. Understanding the bacterial dynamics during the induction and resolution of gingival inflammation will aid in the development of bacterial prognostic tests and probiotics for severe oral disease. We profiled the bacterial community in 15 healthy subjects who suspended all oral-hygiene practices for three weeks. Saliva, tongue, subgingival, and supragingival plaque samples were collected over seven weeks and showed a return to community baseline after oral hygiene practices were resumed. Stronger temporal changes in subgingival and supragingival plaque suggest these sample types may be preferred over saliva or tongue plaque for future prognostics. Taxonomic groups spanning ten phyla demonstrated consistent abundance shifts, including a significant decrease in Streptococcus, Neisseria, and Actinomyces populations, and an increase in Prevotella, Fusobacterium, and Porphyromonas populations. With four distinct oral sites surveyed and results mapped to the Human Oral Microbiome Database reference set, this work provides a comprehensive taxonomic catalog of the bacterial shifts observed during the onset and resolution of gingival inflammation.
Fusion peptide is superior to co-expressing subunits for arming oncolytic herpes virus with interleukin 12
Authors: Fukuhara Hiroshi , Sato Yuzuri Tsurumaki , Hou Jiangang , Iwai Miwako , Todo Tomoki 
Published: March 2023

Abstract
Background
G47∆ is a triple-mutated oncolytic herpes simplex virus type 1 (HSV-1) recently approved as a new drug for malignant glioma in Japan. As the next-generation, we develop armed oncolytic HSV-1 using G47∆ as the backbone. Because oncolytic HSV-1 elicits specific antitumor immunity, interleukin 12 (IL-12) can function as an effective payload to enhance the efficacy.

Methods
We evaluate the optimal methods for expressing IL-12 as a payload for G47∆-based oncolytic HSV-1. Two new armed viruses are generated for evaluation by employing different methods to express IL-12: T-mfIL12 expresses murine IL-12 as a fusion peptide, with the genes of two subunits (p35 and p40) linked by bovine elastin motifs, and T-mIL12-IRES co-expresses the subunits, with the two genes separated by an internal ribosome entry site (IRES) sequence.

Results
T-mfIL12 is significantly more efficient in producing IL-12 than T-mIL12-IRES in all cell lines tested, whereas the expression methods do not affect the replication capabilities and cytopathic effects. In two syngeneic mouse subcutaneous tumor models of Neuro2a and TRAMP-C2, T-mfIL12 exhibits a significantly higher efficacy than T-mIL12-IRES when inoculated intratumorally. Furthermore, T-mfIL12 shows a significantly higher intratumoral expression of functional IL-12, causing stronger stimulation of specific antitumor immune responses than T-mIL12-IRES.

Conclusions
The results implicate that a fusion-type expression of IL-12 is a method superior to co-expression of separate subunits, due to higher production of functional IL-12 molecules. This study led to the creation of triple-mutated oncolytic HSV-1 armed with human IL-12 currently used in phase 1/2 trial for malignant melanoma.
Co‐design of memorized controllers for global sampled‐data stabilization a class of nonlinear system with input delay
Authors: Cao Kecai , Qian Chunjiang , Li Shihua , Gu Juping 
Published: March 2023

AbstractGlobal sampled‐data stabilization for a class of nonlinear continuous system with input delay has been investigated directly in the discrete‐time domain due to challenges confronted in dealing with infinite‐dimensional system under input delay. Memorized state feedback controllers and output feedback controllers based on dynamic extension of state space have been constructed within the framework of co‐design between sampling period and scaling gain. Upon this compensation scheme, global sampled‐data stabilization a class of nonlinear system has been successfully realized no matter the input delay is smaller than the sampling period or not. Compared with memory‐less sampled‐data controllers, not only sampled‐data stabilization under large input delay has been realized but also transient performance of closed‐loop system has been further improved. Simulation results under different input delays and sampling periods have illustrated the effectiveness of results obtained.
A chopper amplifier with a low duty‐cycle sub‐sampling in the switched‐capacitor integrator for noise reduction
Authors: Mu Geng , Lyu Liangjian , Ye Dawei , Richard Shi C.‐J. 
Published: March 2023

AbstractThis letter presents a low‐noise implementation of the switched‐capacitor (SC) DC servo loop (DSL) in the capacitively coupled chopper instrumentation amplifier (CCIA). The noise of the SC integrator in SC DSL is first analyzed, then a low duty‐cycle subsampling and unbalanced capacitor ratio are proposed to reduce the noise. Fabricated in a 65‐nm complementary metal‐oxide semiconductor (CMOS) process, the CCIA achieves 2.5 μVrms input‐referred noise, integrated from 0.5 to 250 Hz, and 110‐mV electrode‐DC offset (EDO) cancellation range. Besides, the calculated noise of the SC integrator well matches the measured, which proves the noise analysis. Compared with prior designs adopting similar SC integrators, this work reduces the noise level by 2× and increases the cancellation range by 2×.
Performance enhancement of parallel‐operated inverter‐based virtual synchronous generators supplying active load
Authors: Rahimi Mohsen , Momenzadeh Morteza , Akhbari Allahyar , Khooban Mohammad Hassan 
Published: March 2023

AbstractInverter‐based virtual synchronous generators (VSGs) by introducing the virtual inertia enhance the microgrid frequency stability. The subject of this paper is regarding the stability analysis and enhancement of the study system comprising parallel‐operated VSGs feeding an active load. The active load with tightly closed‐loop control behaves such as constant power load resulting in stability issue. In the article, impacts of the dc‐side voltage control bandwidth of the active load and power level of active load on the system stability are examined. Then, an approach based on feedback linearising technique implemented on VSGs is presented for stabilising the system at higher levels of active load power. By employing the presented approach, the VSGs show reduced output impedance at the low and middle‐frequency ranges, and this in turn stabilises the system even at the rated level of the active load power and at higher control bandwidths of the active load dc‐side voltage control loop. Next, the linearised state‐space equations of converters and related controllers are transferred from local dq‐reference frames to a common dq‐reference frame, and then stability of the whole study system is analytically examined. At the end, time‐domain simulations and hardware‐in‐the‐loop experiments are given to verify the analytical results.
Integration of the latent variable knowledge into deep image captioning with Bayesian modeling
Authors: Barati Alireza , Farsi Hassan , Mohamadzadeh Sajad 
Published: March 2023

AbstractAutomatic image captioning systems assign one or more sentences to images to describe their visual content. Most of these systems use attention‐based deep convolutional neural networks and recurrent neural networks (CNN‐RNN‐Att). However, they must optimally use latent variables and side information within the image concepts. This study aims to integrate a latent variable into image captioning using CNN‐RNN‐Att. A Bayesian modeling framework is used for this work. As an instance of a latent variable, High‐Level Semantic Concepts (HLSCs) of tags are used to implement the proposed model. The Bayesian model output interpretation is to localize the entire image description process and breaks it down into sub‐problems. Thus, a baseline descriptor subnet is trained independently for each sub‐problem, and it is the only expert in captioning for a given HLSC. The final output is the caption derived from the subnet; its HLSC is closest to the image content. The results indicate that CNN‐RNN‐Att applied to data localized using HLSCs improves the captioning accuracy of the proposed method, which can be compared to the latest state‐of‐the‐art and most accurate captioning systems.
Retuning high Q inductive power transfer systems at MHz frequencies: a switched capacitor design method incorporating COSS
Authors: Jin Rui , Gallichan Robert , Budgett David , Malpas Simon , McCormick Daniel 
Published: March 2023

AbstractHigh Q coils are required by inductive power transfer (IPT) links to attain reasonable levels of power transfer especially for loosely coupled links such as those used for small, deeply implanted medical devices. However, the high Q feature makes IPT systems strongly dependent on operating frequency which must be matched in the primary and secondary resonant tanks. Consequently, power transfer is sensitive to resonant frequency shifts due to component aging and environmental factors. Here, a switched capacitor (SC) network is developed to maintain tight matching and enhance system robustness. The combination of high voltage and high frequency required to achieve power transfer to deeply implanted devices makes the SC network design challenging. High frequencies require small tuning capacitance and high voltage requires MOSFETS with large output capacitance (COSS) resulting in COSS having a significant effect on tuning frequency. This paper proposes a parameter design method incorporating COSS to eliminate the uncertainty of voltage related COSS. In the experiment, the SC network broadens the effective bandwidth from 37 to 585 kHz at the centre frequency of 6.50 MHz. Across a frequency sweep, the worst case in transfer power drop is −0.43 dB, which demonstrates sufficient immunity to parameter deviations.
Detailed Review on Gestational Diabetes Mellitus with Emphasis on Pathophysiology, Epidemiology, Related Risk Factors, and its Subsequent Conversion to Type 2 Diabetes Mellitus
Authors: Gajera Dhruvil , Trivedi Vishva , Thaker Priyanshu , Rathod Mrudang , Dharamsi Abhay 
Published: March 2023

AbstractAny degree of glucose intolerance during the pregnancy of a women is termed as Gestational Diabetes Mellitus (GDM). It may further develop into Type 2 Diabetes Mellitus (T2DM) later in life. GDM affects both mother and infant in multiple ways and there are various factors that predispose the development of GDM.The primary objective of this review is to describe the various aspects related to GDM and the subsequent risk of developing T2DM later in life.We reviewed freely accessible, full-text articles, available in PubMed, Google Scholar, and MEDLINE in the English language, till August 2022 pertaining to GDM.The pathophysiology of underlying glucose intolerance has been discussed, including the various factors like β-Cell dysfunction, chronic insulin resistance, adiponectin, insulin resistance. GDM affects pregnancies world-wide, but it is higher in the South-east Asia, northern America and Caribbean, south and central America regions. Along with ethnicity, various modifiable and non-modifiable risk factors also play a major role in development of disease. Although no standard diagnostic criteria is accepted world-wide for screening of GDM, but the one-step and two-step approach has made quite a difference. The risk of developing T2DM after GDM is well documented, and it increases with age. GDM leads to an onset of diabetes in the family at a young age, it leads to poor consequences on the health of both the mother and infant. Standard diagnostic criteria, proper education and counselling of the mother is required to tackle the condition.
Are All Patients Going Home after Total Knee Arthroplasty? A Temporal Analysis of Discharge Trends and Predictors of Nonhome Discharge (2011–2020)
Authors: Pan Xuankang , Xu James , Rullán Pedro J. , Pasqualini Ignacio , Krebs Viktor E. , Molloy Robert M. , Piuzzi Nicolas S. 
Published: March 2023

AbstractValue-based orthopaedic surgery and reimbursement changes for total knee arthroplasty (TKA) are potential factors shaping arthroplasty practice nationwide. This study aimed to evaluate (1) trends in discharge disposition (home vs nonhome discharge), (2) episode-of-care outcomes for home and nonhome discharge cohorts, and (3) predictors of nonhome discharge among patients undergoing TKA from 2011 to 2020. The National Surgical Quality Improvement Program database was reviewed for all primary TKAs from 2011 to 2020. A total of 462,858 patients were identified and grouped into home discharge (n = 378,771) and nonhome discharge (n = 84,087) cohorts. The primary outcome was the annual rate of home/nonhome discharges. Secondary outcomes included trends in health care utilization parameters, readmissions, and complications. Multivariable logistic regression analyses were performed to evaluate factors associated with nonhome discharge. Overall, 82% were discharged home, and 18% were discharged to a nonhome facility. Home discharge rates increased from 65.5% in 2011 to 94% in 2020. Nonhome discharge rates decreased from 34.5% in 2011 to 6% in 2020. Thirty-day readmissions decreased from 3.2 to 2.4% for the home discharge cohort but increased from 5.6 to 6.1% for the nonhome discharge cohort. Female sex, Asian or Black race, Hispanic ethnicity, American Society of Anesthesiology (ASA) class > II, Charlson comorbidity index scores > 0, smoking, dependent functional status, and age > 60 years were associated with higher odds of nonhome discharge. Over the last decade, there has been a major shift to home discharge after TKA. Future work is needed to further assess if perioperative interventions may have a positive effect in decreasing adverse outcomes in nonhome discharge patients.
Preoperative Corticosteroid Injections Are Not Associated with Deep Infection after Unicompartmental Knee Arthroplasty
Authors: McCormick Johnathon R. , Berlinberg Elyse J. , Oladipo Victoria , Forlenza Enrico M. , Forsythe Brian , Gerlinger Tad L. 
Published: March 2023

AbstractPrior to unicompartmental knee arthroplasty (UKA), corticosteroid injections (CSI) are a common nonoperative treatment for arthritis. It is unclear whether CSI prior to UKA impacts the likelihood of postoperative infection. This study sought to determine if there is a time- and/or dose-dependent relationship between preoperative CSI and postoperative infection. An administrative claims database was queried for patients undergoing UKA with more than 1 year of pre-enrollment and follow-up. Of 31,676 patients with a UKA who met enrollment criteria, 8,628 patients had a CSI 0 to 3 months prior to surgery, 111 had a CSI 3 to 12 months prior to surgery, and 22,937 never received an injection. Overall, 246 postoperative deep infections were reported (0.8%). Time-dependent and dose-dependent relationships were modeled using multivariable logistic regressions. Postoperative deep infections occurred in 64 patients with CSI 0 to 3 months prior to surgery (0.7%), compared with 0 patients with CSI 3 to 12 months before surgery (0.0%) and 182 controls (0.8%, p = 0.58). CSI within 1 month prior to UKA was not statistically associated with postoperative infection (p = 0.66). Two or more CSI within 3 months prior to UKA were associated with a twofold elevated odds of infection, compared with receiving a single injection (odds ratio [OR]: 2.08, p = 0.03). Univariable predictors of infection included younger age, increasing Charlson Comorbidity Index, smoking, asthma, chronic obstructive pulmonary disease, chronic kidney disease, diabetes, liver disease, and obesity. Multivariable analysis controlling for these characteristics elicited no relationship between recent CSI administration and postoperative infection. CSI within 3 months of surgery (1.5%) or 3 to 12 months (1.8%) were associated with increased conversion to total knee arthroplasty (TKA) compared with those who did not receive an injection (1.1%, p = 0.01), although TKA for indication of periprosthetic joint infection was not statistically different (p = 0.72). Preoperative CSI within 3 months of UKA is not associated with postoperative infection, although significant medical comorbidity does show an association. Preoperative CSI is associated with increased conversion from UKA to TKA for noninfectious indications.
Adipose Mesenchymal Stem Cell Metabolites Oral Gel Enhance Pro-Angiogenic Factors Expression, Angiogenesis, and Clinical Outcome of Oral Ulcer Rat Model
Authors: Wicaksono Satutya , Nugraha Alexander Patera , Rahmahani Jola , Rantam Fedik Abdul , Kuncorojakti Suryo , Susilowati Helen , Riawan Wibi , Arundina Ira , Lestari Pudji , Masya Resgita Nadila , Surboyo Meircurius Dwi Condro , Ernawati Diah Savitri 
Published: March 2023

Abstract
Objective Enhancing wound healing capacity is one of the main principles in oral ulcer management. Efficient oral ulcer management will accelerate clinical symptom amelioration and prevent complications. Adipose mesenchymal stem cell metabolites (AdMSCM), a novel biological product, contains a plethora of bioactive mediators that can induce a series of processes in wound healing. This study will analyze the clinical outcome, angiogenesis, and expression of FGF-2 and VEGFA in the oral ulcer rat model after AdMSCM oral gel application.
Materials and Methods Twenty healthy male Wistar rats (Rattus novergicus) were used to create oral ulcer animal models. AdMSCM oral gel treatment was performed three times daily for 3 and 7 days. Clinical outcome was assessed by measuring the major diameter of the ulcer; the angiogenesis was evaluated through histological assessment; the expression of VEGFA and FGF-2 was assessed using the immunohistochemistry method.
Statistical Analysis This study uses parametric comparative analysis using one-way analysis of variance (ANOVA) and post-hoc Tukey's HSD test
Results The application of AdMSCM oral gel in an oral ulcer rat model significantly enhanced the clinical outcome (p < 0.05). In addition, similar results were shown in the histologic assessment of angiogenesis and supported by the significant increase of VEGFA and FGF-2 expression.
Conclusions AdMSCM oral gel accelerates oral ulcer healing processes, proven by the enhancement of angiogenesis, pro-angiogenic factors expression, and clinical outcomes.
Measuring Quality at the Surgeon Level
Authors: Chamely Elias A. , Stulberg Jonah J. 
Published: March 2023

AbstractPatients expect high-quality surgical care and increasingly are looking for ways to assess the quality of the surgeon they are seeing, but quality measurement is often more complicated than one might expect. Measurement of individual surgeon quality in a manner that allows for comparison among surgeons is particularly difficult. While the concept of measuring individual surgeon quality has a long history, technology now allows for new and innovative ways to measure and achieve surgical excellence. However, some recent efforts to make surgeon-level quality data publicly available have highlighted the challenges of this work. Through this chapter, the reader will be introduced to a brief history of surgical quality measurement, learn about the current state of quality measurement, and get a glimpse into what the future holds.