bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical study of analgesia in brachytherapy for cervical cancer
Authors: Liu Mei , Wu Hai‐Yan , Li Jian , Ou Meng‐Yu , Sun Shu‐Fang , Tang Ying , Zhao Xiu‐Juan 
Published: June 2023

AbstractObjectiveThis study investigated the analgesic effects in patients with cervical cancer during brachytherapy.MethodsIn this prospective study, 100 patients with cervical cancer who were admitted to Chongqing University Cancer Hospital between July 2021 and April 2022 were randomly divided into an analgesia group (n = 50) and a control group (n = 50). The visual analog scale (VAS) scores at applicator placement‐T1, CT‐scan‐T2, and removal ‐T3, self‐rating anxiety scale (SAS) and self‐rating depression scale (SDS) scores before brachytherapy, short‐term clinical efficacy, and patient satisfaction were compared between the two groups.ResultsThe VAS score of the analgesia group was significantly different at T1 (0 vs. 4.34±1.02, t = 67.40, p < 0.001), but not in the control group; however, there was no significant difference between the two groups at T2 (t = ‐0.49, p = 0.623) and T3 (t = ‐0.12, p = 0.912). The SAS and SDS scores first decreased and then increased in the analgesic group and increased in the control group with increasing brachytherapy time. Except for the first measurement, the differences between the two groups were statistically significant (all p < 0.001). The application of interstitial implantation (p = 0.027), local efficacy (p = 0.047), and patient satisfaction rates (p = 0.025) were higher in the analgesic group than in the control group.ConclusionAnalgesia can relieve pain, maintain physical and mental health, and improve outcomes and patient satisfaction rates for cervical cancer.
Evaluation of the optimal strategy in men with a single unilateral suspicious lesion on MRI undergoing transperineal MRI/ultrasound fusion prostate biopsy
Authors: Yusim Igor , Mazor Elad , Frumkin Einat , Jabareen Muhammad , Hefer Ben , Elsaraya Nimer , Li Sveta , Rouvinov Keren , Novack Victor , Mabjeesh Nicola J. 
Published: June 2023

AbstractBackgroundTargeting biopsy (TBx) of suspicious lesions combined with random systematic biopsy (SBx) improves detection rates of prostate cancer (PCa) during magnetic resonance imaging (MRI)/ultrasound (US) fusion prostate biopsy. However, this combination increases the number of biopsy cores, prolongs the procedure time, and increases complications and costs, leading to the overdiagnosis of clinically insignificant PCa (ciPCa). This study aims to evaluate the optimal sampling design to achieve a detection rate of clinically significant PCa (csPCa) equal to standard TBx with SBx with fewer biopsy cores.Materials and MethodsOf 508 consecutive men who underwent transperineal MRI/US fusion prostate biopsy at our center between January 2020 and December 2022, 364 patients with a single unilateral suspicious lesion on MRI were included in the study. Three biopsy strategies were randomly selected to evaluate the diagnostic accuracy of PCa detection: (1) TBx with ipsilateral SBx, (2) TBx with contralateral SBx, and (3) TBx only. The PCa detection sensitivity for selected biopsy strategies was compared with the reference standards. The significance of differences in cancer detection between sampling schemes was determined using McNemar's test.ResultsPCa was diagnosed in 182 of 364 men using TBx with bilateral SBx. International Society of Urological Pathology grade group (ISUP GG) ≥ 2 and ISUP GG ≥ 3 PCa was detected in 84/364 (23.1%) and 42/364 (11.5%), respectively, while ISUP GG 1 PCa was diagnosed in 98/364 (26.9%). Combining TBx with ipsilateral SBx detected 94.5% of all, 98.8% of ISUP GG ≥ 2, 100% of ISUP GG ≥ 3, and 89.8% of ISUP GG 1 PCa. TBx with contralateral SBx detected fewer csPCa (91.7% vs. 98.8%, p = 0.03), as did TBx alone (90.5 vs. 98.8, p = 0.008).ConclusionsOur study demonstrates that TBx with ipsilateral SBx performed around the multiparametric MRI‐suspected lesion in transperineal MRI/US biopsy of the prostate achieves a very high detection rate for csPCa (ISUP ≥ 2) without compromising the detection of increased risk PCa (ISUP ≥ 3). In addition, this strategy reduces the number of biopsy cores by 8–10 per patient, procedure time, and pathology processing costs and decreases ciPCa detection.
Exploring the nexus between competition and the sustainable development goals in OECD countries
Authors: Gani Walid 
Published: June 2023

AbstractIn recent years, the OECD has been embroiled in discussions on the role of competition law in achieving the sustainable development goals (SDGs). However, it is crucial to understand whether the SDGs and competition work in harmony or are at odds before devising the best strategies for tackling sustainability challenges in competition laws and policies. For this purpose, this paper aims to empirically explore the interplay between sustainability and competition to fill the gap between economic theory and observed data through a study of a panel of 18 OECD countries from 2000 to 2019. The non‐declining inclusive wealth approach serves as the foundation for our model to evaluate sustainability. The SDG Index, which incorporates the socio‐economic and environmental aspects of sustainability, is used as a gauge of the SDGs' achievement, while the Index of Economic Freedom is used as a proxy for competition. The results of the feasible generalized least squares and panel‐corrected standard errors (PCSE) methods reveal that competition has no effect on the SDGs. Our empirical findings also show that the achievement of the SDGs is positively impacted by per capita gross national income and negatively impacted by population growth. The PCSE method's results indicate that the SDGs are not significantly affected by natural capital depletion, as measured by natural resource rents. Besides, the panel causality analysis confirms the existence of a causal relationship between the SDGs and competition. Our empirical results have two implications. First, they show that competition laws are still far from being an effective tool capable of achieving the SDGs. Second, they drive the competition authorities of OECD countries to devote greater efforts to sustainability‐related issues in the enforcement of competition law.
Experimental design and power calculation in omics circadian rhythmicity detection using the cosinor model
Authors: Zong Wei , Seney Marianne L. , Ketchesin Kyle D. , Gorczyca Michael T. , Liu Andrew C. , Esser Karyn A. , Tseng George C. , McClung Colleen A. , Huo Zhiguang 
Published: June 2023

SummaryCircadian clocks are 24‐h endogenous oscillators in physiological and behavioral processes. Though recent transcriptomic studies have been successful in revealing the circadian rhythmicity in gene expression, the power calculation for omics circadian analysis have not been fully explored. In this paper, we develop a statistical method, namely CircaPower, to perform power calculation for circadian pattern detection. Our theoretical framework is determined by three key factors in circadian gene detection: sample size, intrinsic effect size and sampling design. Via simulations, we systematically investigate the impact of these key factors on circadian power calculation. We not only demonstrate that CircaPower is fast and accurate, but also show its underlying cosinor model is robust against variety of violations of model assumptions. In real applications, we demonstrate the performance of CircaPower using mouse pan‐tissue data and human post‐mortem brain data, and illustrate how to perform circadian power calculation using mouse skeleton muscle RNA‐Seq pilot as case study. Our method CircaPower has been implemented in an R package, which is made publicly available on GitHub (
https://github.com/circaPower/circaPower).
Synthesis, Biological Evaluation, in silico ADMET and Molecular Docking of new 1,4‐Dihydropyridine Derivatives Bearing Ether Substitution as Calcium Channel Blockers
Authors: Zare Fateme , Hashemi Hakimeh , Hassani Bahareh , Fazel Razieh , Miri Ramin , Sadeghpour Hossein 
Published: June 2023

AbstractA set of 1,4‐dihydropyridine derivatives were synthesized, possessing methyl or ethyl esters at positions 3 and 5, an aliphatic or aromatic ether group at position 2, and a thienyl ring at position 4. The calcium channel blocking activity of these derivatives was investigated using K+‐induced contraction on the longitudinal smooth muscles of guinea pig ileum (GPILSM). Our findings showed that the derivatives had IC50 ranging from 0.5 to 5.2 μM. Among the synthesized compounds, compound including methoxy group in position 2 and ethyl acetate in positions 3 and 5, with IC50=0.55±0.58 μM was almost comparable to that of nifedipine (IC50=0.27±1.23 μM). The results of docking studies and biological evaluation of synthetic compounds were consistent. According to the physicochemical and drug‐likeness parameters, it is predicted that the synthesized compounds can be a suitable candidate for calcium channel blocking.
Therapeutic Potential of Genistein and its Derivatives as a Target for Anticancer Agents
Authors: Gupta Nidhi , Gupta Sumeet , Kumar Manish , Guarve Kumar , Dhanawat Meenakshi , Sharma Vishal 
Published: June 2023

AbstractGenistein is a natural isoflavone and a phytoestrogen known to possess broad range of pharmacological properties specifically explored for anticancer effects. The compound is under clinical trials for different types of cancer treatment. Structural modification of genistein has been done to prepare analogs with improved anticancer potential and pharmaceutical properties. Also, novel formulations of genistein have been developed to further improve water solubility and bioavailability for better clinical effectiveness. In the present review, we have summarized the recent available literature on genistein anticancer effects along with mechanism of action and clinical trial studies, reported analogs and novel formulations developed for improving the anticancer efficacy of genistein during the period 2013–2022. Also, the structure activity relationship (SAR) study of reported genistein analogs is described. Further, articles published in this period showed that both genistein and its various derivatives exhibit promising potential for the development of effective chemotherapeutic agents against different types of cancer. Further, the present review will help the researchers in design and development of genistein formulation with desired drug profile.
Preparation of Nanodiamond‐Fucoxanthin and Its Application as a Nanodrug Delivery System
Authors: Dou Yanyu , Yang Tao , Sun Yanyan , Zhao Wei , Zhang Peijuan 
Published: June 2023

AbstractNanodiamonds (NDs) are advantageous for targeted cancer treatment with payload medications due to their good biocompatibility. Herein, a nanodrug delivery system, ND‐fucoxanthin (ND‐FX), was generated by combining FX and acyl chloride‐functionalized NDs, which were created by dispersing and surface‐modifying NDs. The structure and characteristics of NDs were examined via X‐ray diffraction, transmission electron microscopy, and Fourier transform infrared spectroscopy. Subsequently, the drug‐loading and ‐release rates of ND‐FX under different pH conditions were calculated using ultraviolet‐visible spectrophotometeric analysis. The drug‐loading rate of the ND‐FX system was 13.17 %; release rate of FX at pH 7.4 and 6.5 was 27.79 % and 54.65 %, respectively; and cumulative release rate of ND‐FX reached 79.98 % over a release duration of 72 h at pH 5.0. Meanwhile, in vitro cytotoxicology experiments demonstrated that ND‐FX effectively inhibited the activity of HeLa and HepG2 cells. These results demonstrate the potential value of NDs in the field of nanodrug delivery applications.
Enhanced Antifungal Activity of Electrosprayed Poly (vinyl alcohol)/Chitosan Nanospheres Loaded with Sage Essential Oil on the Viability of Aspergillus niger and Botrytis cinerea
Authors: Erarslan Azime , Karakas Canan Yagmur , Bozkurt Fatih , Sagdic Osman 
Published: June 2023

AbstractIn this study, sage essential oil (SEO) loaded nanoparticles were tested in terms of their antifungal properties. In this respect, the electrospray method was employed to fabricate SEO‐loaded nanoparticles (SNPs) by encapsulation of different concentrations (0.0, 0.25 %, 0.5 %, and 1 % v/v) of SEO within poly(vinyl alcohol)/chitosan‐based nanoparticles (PVA/Chi NPs). The FTIR, DSC, and SEM analyses divulged that SEO could be successfully encapsulated within nanoparticles, possessing a spherical shape and high thermal stability. The encapsulation efficiency values of SNPs at different concentrations varied between 66.1 and 73.3 %. It was determined that SNPs released 62.56 % of their SEO content within 350 minutes. Moreover, the antifungal activity of SEO against Aspergillus niger and Botrytis cinerea could be increased significantly (p<0.05) after it was encapsulated into PVA/Chi NPs. Based on these findings, suggest that SNPs could be used in food preservation applications as a long‐term and natural preservative given their controlled release properties.
ZnxMg1‐xO Solid Solutions: Efficient Bifunctional Acid‐Base Catalyst for the synthesis of Methyl Ethyl Oxalate from Dimethyl Oxalate and Ethanol
Authors: Wang Hefang , Shao Kai , Jiang Hui , Wang Cui , Ma Xiaofei , Pan Yupeng , Wang Haimeng 
Published: June 2023

AbstractZnO‐MgO composite catalysts were prepared by the coprecipitation method and used for the synthesis of methyl ethyl oxalate (EMO) from dimethyl oxalate (DMO) and ethanol (EtOH). The results of the SEM, XRD, FT‐IR and XPS confirmed that Zn2+ ions were incorporated into the cubic MgO lattice to form the solid solution structure over ZnO‐MgO composites catalysts with 6–18 mol% ZnO. The ZnO‐MgO composite catalysts with a solid solution structure have a large specific surface area, high medium acidic density, and medium basic density according to the results of N2 adsorption‐desorption, pyridine‐IR (Py‐IR) and NH3/CO2 temperature‐programmed desorption (NH3‐TPD/CO2‐TPD). The ZnxMg1‐xO solid solution with 18 mol% ZnO‐MgO (Zn0.18Mg0.82O) catalyst showed the highest catalytic activity with 71.98 % conversion of DMO and 67.36 % selectivity to EMO (DMO: EtOH molar ratio=1 : 2, reaction time=20 min, reaction temperature=80 °C and catalyst amount=1.5 wt%). The high catalytic activity was attributed to the solid solution structure with high medium acidic density and medium basic density. The conversion of DMO showed a positive linear correlation with the medium acidic density and medium basic density according to the correlation between catalytic activity and acidity‐basicity.
Exploring the Bicorannulenyl Surface for Alkali Metal Doping: Towards a New NLO Material
Authors: Parveen Azra , Yaqoob Junaid , Ijaz Shahzaib , Baloach Rimsha , Khan Muhammad Usman , Hussain Riaz , Abo‐Dief Hala M. , Alanazi Abdullah K. , El‐Bahy Zeinhom M. 
Published: June 2023

AbstractRecent years have seen a rise in the importance of designing materials with large nonlinear optical (NLO) responses. Different compounds having large nonlinear optical responses are being extensively studied for their boundless applications in this field. Contributing to this, we are presenting here an attempt to design novel nonlinear optical materials. In this study, alkali metal‐doped bicorannulenyl (C40H38) compounds (Li@Bicora, Na@Bicora, and K@Bicora) are designed and computationally investigated by using DFT calculations. Thermodynamic stabilities of all complexes are evident from their binding energies. A prodigious first hyperpolarizability value is observed after doping the bicorannulenyl with alkali metals. A significantly enhanced hyperpolarizability value (βo=2.68×106 au) is shown by isomer VII of K@Bicora. Other analyses, such as TDOS and PDOS, NBO, QTAIM and NCI, are also performed to investigate the contributions of various systems, charge transfer, and modes of interaction. Absorption analysis has confirmed the transparency in the UV region. This theoretical insight into NLO material‘s prodigious NLO response will serve as a springboard for novel ideas in this area.
Influence of Zinc Salt Concentration on Structured ZnO Composition and Morphology
Authors: Al‐Rasheedi Asmaa , Shalaan Essayed , Hassaneen Ali Abdeldaim , Aida Mohammed Salah 
Published: June 2023

AbstractIn the present work, Zinc oxide nanorods (ZnO NRs) and Simonkolleite (Zn5(OH)8Cl22H2O) nanodisks were successfully prepared hydrothermally using zinc chloride as a zinc source salt. The molarity of the zinc salt was varied to investigate its effect on the structure of the synthesized nanostructures. X‐ray diffraction (XRD), scanning electron microscopy (SEM), UV‐visible optical transmittance, and photoluminescence were used to characterize the synthesized nanostructures. These results suggest that the morphology of the synthesized nanostructures was significantly influenced by the molarity of zinc chloride. We inferred that increasing zinc salt molarity above 0.01 M leads to a pure simonkolleite nanodisks. In contrast, ZnO NRs were formed at low concentrations.
Organocatalytic Decarboxylation of 2‐phenylbutanoic Acid and 1,4‐dicyanobenzene: A DFT Investigation
Authors: Chen Bin , Hou Hongxia , Zhou Dagang , Yang Lijun , Li Rong , Zhou Panpan 
Published: June 2023

AbstractMechanisms of photo‐catalytic decarboxylative reaction between 2‐phenylbutanoic acid and 1,4‐dicyanobenzene (1,4‐DCB) have been investigated with the method of M06‐L/ma‐def2‐TZVP in the domain‐decomposition COnductor‐like Screening MOdel (ddCOSMO) of CH3CN. The TDDFT calculations of 1,4‐DCB and 2‐phenylbutanoic acid model have revealed the photo‐excitation and electron transfer process, which could agree with experimental phenomena. The computational results of Gibbs free energy profiles show that the R1+1,4‐DCB model could achieve the decarboxylative reaction under the 300 nm UV light in path c. And paths a and b indicate that HPO42− and K2HPO4 could assist the whole reaction process with lower energy barrier successfully. Results would provide valuable insights into these types of interactions and related ones.
An Off‐On‐Off Benzoxazole‐Based Fluorosensor for Relay Detection of Al3+ Ions and Explosive Nitroaromatic Compounds
Authors: Tohora Najmin , Sultana Tuhina , Mahato Manas , Ahamed Sabbir , Das Sudhir Kumar 
Published: June 2023

AbstractDeveloping fluorosensors for the efficient detection of aluminium (Al3+) ions and electron‐deficient nitroaromatic compounds (NACs) is in high demand but challenging. This report introduces a benzoxazole‐based off‐on‐off fluorosensor for the cascade detection of Al3+ ions and electron‐deficient NACs. Upon addition of Al3+ ions, the probe BPMP displays a bright blue fluorescence under the exposure of 365 nm UV light radiation in an H2O/DMSO (1 : 1 v/v) medium due to the chelation of Al3+ ions disrupting the ESIPT process involved in probe BPMP. The detection limit for Al3+ ions is found to be 13 nM, which is significantly lower than many chemosensors available in the literature. The 1 : 1 stoichiometry of the chelated complex between BPMP and Al3+ ions is confirmed by Job′s plot and also by 1H NMR titration investigation. More importantly, the Al3+ ions chelated BPMP complex is further used as a fluorescent turn‐off probe for the detection of electron‐deficient NACs with the detection as low as 10−7 M. Based on these chemically encoded inputs and the corresponding optical output, we have constructed one input and one output based YES, and NOT logic gate with BPMP and BPMP‐Al3+ complex as input respectively and also dual inputs and single optical output‐based INHIBIT logic gates. Also, BPMP‐doped paper strips‐based test kit analysis has been demonstrated as a displayable photonic device for on‐spot detection. The performance of BPMP and Al3+ ions chelated BPMP complex toward Al3+ ions and electron‐deficient NACs demonstrated that BPMP could be served as a sensitive probe and could be employed for real sample analysis.
Vascular Electrical Stimulation with Wireless, Battery‐Free, and Fully Implantable Features Reduces Atherosclerotic Plaque Formation Through Sirt1‐Mediated Autophagy
Authors: Wang Pengyu , Li Manman , Gao Tielei , Fan Jiaying , Zhang Dengfeng , Zhao Ying , Zhao Yajie , Wang Yuqin , Guo Tianwei , Gao Xi , Liu Yujun , Gao Yang , Guan Xue , Sun Xinyong , Zhao Jiyi , Li Hong , Yang Liming 
Published: June 2023

AbstractElectrical stimulation (ES) is a safe and effective procedure in clinical rehabilitation with few adverse effects. However, studies on ES for atherosclerosis (AS) are scarce because ES does not provide a long‐term intervention for chronic disease processes. Battery‐free implants and surgically mounted them in the abdominal aorta of high‐fat‐fed Apolipoprotein E (ApoE−/−) mice are used, which are electrically stimulated for four weeks using a wireless ES device to observe changes in atherosclerotic plaques. Results showed that there is almost no growth of atherosclerotic plaque at the stimulated site in AopE−/− mice after ES. RNA‐sequencing (RNA‐seq) analysis of Thp‐1 macrophages reveal that the transcriptional activity of autophagy‐related genes increase substantially after ES. Additionally, ES reduces lipid accumulation in macrophages by restoring ABCA1‐ and ABCG1‐mediated cholesterol efflux. Mechanistically, it is demonstrated that ES reduced lipid accumulation through Sirtuin 1 (Sirt1)/Autophagy related 5 (Atg5) pathway‐mediated autophagy. Furthermore, ES reverse autophagic dysfunction in macrophages of AopE−/− mouse plaques by restoring Sirt1, blunting P62 accumulation, and inhibiting the secretion of interleukin (IL)‐6, resulting in the alleviation of atherosclerotic lesion formation. Here, a novel approach is shown in which ES can be used as a promising therapeutic strategy for AS treatment through Sirt1/Atg5 pathway‐mediated autophagy.
A Dual‐Targeting Liposome Enhances Triple‐Negative Breast Cancer Chemoimmunotherapy through Inducing Immunogenic Cell Death and Inhibiting STAT3 Activation
Authors: Luo Kaipei , Yang Lu , Yan Chunmei , Zhao Yuxin , Li Qiuxia , Liu Xing , Xie Long , Sun Qiang , Li Xiaofang 
Published: June 2023

AbstractImmunotherapy gains increasing focus in treating triple‐negative breast cancer (TNBC), while its efficacy is greatly restricted owing to low tumor immunogenicity and immunosuppressive tumor microenvironment (ITM). Herein, a LyP‐1 and chondroitin sulfate (CS) dual‐modified liposome co‐loaded with paclitaxel (PTX) and cryptotanshinone (CTS), namely CS/LyP‐1‐PC Lip, is engineered for TNBC chemoimmunotherapy via induction of immunogenic cell death (ICD) and inhibition of signal transducer and activator of transcript‐3 (STAT3) activation. CS/LyP‐1‐PC Lip enhances cellular uptake through p32 and CD44 dual receptor‐mediated endocytosis. Within the tumor, the CS layer is continuously detached by hyaluronidase to release drugs. Subsequently, CTS sensitizes the cytotoxicity of PTX to 4T1 tumor cells. PTX induces ICD of tumor cells and facilitates infiltration of cytotoxic T lymphocyte to provoke immune response. Meanwhile, the concomitant delivery of CTS inhibits STAT3 activation to decrease infiltration of regulatory T cell, M2‐type tumor‐associated macrophage, and myeloid‐derived suppressor cell, thus reversing ITM. Markedly, the dual‐targeting liposome shows superior anti‐tumor efficacy in subcutaneous TNBC mice and significant lung metastasis suppression in tumor metastasis model. Overall, this work offers a feasible combination regimen and a promising nanoplatform for the development of TNBC chemoimmunotherapy.