bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prognostic significance of the CFA ratio for newly diagnosed acute myeloid leukemia: A multicenter retrospective study
Authors: Sakuma Takayuki , Fujisawa Shin , Tanaka Masatsugu , Hagihara Maki , Fujita Hiroyuki , Fujimaki Katsumichi , Katsuki Kengo , Akimoto Masahiro , Tanaka Marika , Matsumura Ayako , Teshigawara Haruka , Suzuki Taisei , Teranaka Hiroshi , Nakajima Yuki , Miyazaki Takuya , Tachibana Takayoshi , Matsumoto Kenji , Sakai Rika , Kanamori Heiwa , Nakajima Hideaki 
Published: September 2023

AbstractThe CFA ratio, calculated using pretreatment C‐reactive protein (CRP), fibrinogen, and albumin levels (CRP × fibrinogen/albumin), was previously reported to be a significant prognostic factor for acute myeloid leukemia (AML). This multicenter retrospective study evaluated the prognostic value of the CFA ratio in 328 adult patients with newly diagnosed AML from April 2000 to March 2018. The median age was 49.5 years (range, 15–75 years), and 60.7% of the population were males. According to the European LeukemiaNet (ELN) risk classification, 67 patients (20.4%) were in the favorable‐risk group, 197 patients (60.1%) in the intermediate‐risk group, and 58 patients (17.7%) in the adverse‐risk group. The median CFA ratio was 1.07 (0–67.69). Based on the calculated cutoff CFA ratio of 1.44, the cohort included 176 and 152 patients with low and high CFA ratios, respectively. At a median follow‐up of 91.2 months, the 7‐year overall survival (OS) and disease‐free survival (DFS) rates were 51.2% and 48.6%, respectively, in the overall cohort. The 7‐year OS rates were 61.7% and 39.0% in the low and high CFA ratio groups, respectively (p < 0.001). The 7‐year DFS rates were 58.1% and 37.0% in the low and high CFA ratio groups, respectively (p = 0.004). In univariate analysis, age ≥50 years, male sex, ELN risk class, and comorbidities were associated with poor OS. Age, ELN risk class, comorbidities, and high CFA ratio were associated with poor OS in multivariate analysis. Subgroup analysis revealed that the CFA ratio was significant in the intermediate and adverse ELN risk classes. These findings indicate the prognostic significance of the CFA ratio in AML.
Exploring causes of neonatal mortality in south east of Iran: A qualitative study
Authors: Amini Elham , Heidarzadeh Mohammad , Sohbati Samira , Behseresht Maryam , Amiresmaili Mohammadreza 
Published: September 2023

AbstractAimNeonatal mortality (NM) is a significant global challenge that has a profound impact on families, particularly mothers. To address this challenge, the first step is to identify its underlying causes. Accordingly, this study aimed to explore the phenomenon by consulting with stakeholders, including mothers and experts.Study DesignThis study utilized a qualitative design, conducting in‐depth interviews with 16 mothers and 15 healthcare experts to gather information. A conventional content analysis approach was employed to analyze the data.ResultsNM is influenced by personal, systemic, and socioeconomic factors. Personal factors can be further divided into those related to the neonate and those related to the mother. Systemic factors are primarily related to the healthcare system, while socioeconomic factors include low literacy, low income, lack of access to healthcare, and consanguineous marriage.ConclusionNM is influenced by a wide range of factors that require separate and targeted interventions to reduce its incidence. In the short term, priority should be given to preventable factors that can be addressed through simple interventions, such as screening mothers for urinary tract infections, educating mothers, and preparing them for pregnancy with necessary lab tests and supplements. In the long term, preventing premature birth, addressing maternal addiction, family poverty, and shortages in healthcare equipment and personnel must be thoroughly addressed.
Diagnostic accuracy of MRI in the differential diagnosis between uterine leiomyomas and sarcomas: A systematic review and meta‐analysis
Authors: Raffone Antonio , Raimondo Diego , Neola Daniele , Travaglino Antonio , Giorgi Matteo , Lazzeri Lucia , De Laurentiis Francesco , Carravetta Carlo , Zupi Errico , Seracchioli Renato , Casadio Paolo , Guida Maurizio 
Published: September 2023

AbstractBackgroundDifferential diagnosis between uterine leiomyomas and sarcomas is challenging. Magnetic resonance imaging (MRI) represents the second‐line diagnostic method after ultrasound for the assessment of uterine masses.ObjectivesTo assess the accuracy of MRI in the differential diagnosis between uterine leiomyomas and sarcomas.Search StrategyA systematic review and meta‐analysis was performed searching five electronic databases from their inception to June 2023.Selection CriteriaAll peer‐reviewed observational or randomized clinical trials that reported an unbiased postoperative histologic diagnosis of uterine leiomyoma or uterine sarcoma, which also comprehended a preoperative MRI evaluation of the uterine mass.Data Collection and AnalysisSensitivity, specificity, positive and negative likelihood ratios, diagnostic odds ratio, and area under the curve on summary receiver operating characteristic of MRI in differentiating uterine leiomyomas and sarcomas were calculated as individual and pooled estimates, with 95% confidence intervals (CI).ResultsEight studies with 2495 women (2253 with uterine leiomyomas and 179 with uterine sarcomas), were included. MRI showed pooled sensitivity of 0.90 (95% CI 0.84–0.94), specificity of 0.96 (95% CI 0.96–0.97), positive likelihood ratio of 13.55 (95% CI 6.20–29.61), negative likelihood ratio of 0.08 (95% CI 0.02–0.32), diagnostic odds ratio of 175.13 (95% CI 46.53–659.09), and area under the curve of 0.9759.ConclusionsMRI has a high diagnostic accuracy in the differential diagnosis between uterine leiomyomas and sarcomas.
An automatic measurement method for ankle key angles based on point cloud segmentation network
Authors: Chang Cheng , Sun Hao , Guo Xin , Sun Zhenhui , Wu Mengkun , Yin Minghuan , An Baichuan , Zhuang Chao 
Published: September 2023

AbstractIn clinical practice, anterior distal tibialangle (ADTA) and lateral distal tibialangle (LDTA) are important evaluation indexes, which can reflect the degree of deformity and determine the type of deformity to a certain extent. The measurement process of these parameters involves the localization of multiple key regions. To simplify the process of measuring ADTA and LDTA, an automatic measurement method is proposed. First, this study constructs an ankle 3D point cloud dataset by 3D reconstruction of ankle electron computed tomography (CT) data, and then, an ankle point cloud segmentation network with a Self‐Attention mechanism and kernel point convolution combined with each other is constructed, and the ankle point cloud data with labels are input to this network to predict the ankle bone feature points. Finally, the segmented feature points are fitted, and the tibial backbone axis and distal tibial articular surface can be drawn, and based on the fitting results, ADTA and LDTA are obtained. Compared with manual measurements by physicians, the proposed method in this study achieved an average error of 0.46° with a passing rate of 97.7% for ADTA measurement. For LDTA measurement, the average error was 0.69° with a passing rate of 98%. The ankle joint key angle measurement system developed in this study meets the accuracy requirements of orthopedics and significantly reduces the workload for doctors.
Fast autofocusing of recorded planes by salient feature region for coherent diffraction imaging
Authors: Zhou Xuyang , Li Ziyang , Qiao Ziling , Wang Yiran , Huang Guancheng , Chi Dazhao , Li Xiaomei , Liu Shutian , Liu Zhengjun 
Published: September 2023

AbstractIn multi‐distance coherent diffraction imaging, the task of distance calculation for multi‐diffraction images is cumbersome. The information features are hard‐to‐extract and the region of interest extraction algorithms are difficult to be adopted. A universal salient feature region selection algorithm by using the area with the highest density of corners is proposed to extract the most representative feature region. In addition, equally spaced recording modes and mismatched diffraction distances will result in system noise and destroy image quality. The polydirectional maximum gradient is offered as a sharpness criterion to weigh a quantitative feature for the final pattern. A fast, sensitive, and high‐accuracy autofocusing and sample reconstruction can be achieved using only a small number of images while ensuring that morphological properties and quantification of the reconstructions are not compromised. The proposed method is promising for biological and medical dynamic observations for computational imaging systems.
Performing well but not appreciating it – A trait feature of anorexia nervosa
Authors: Hjerresen Tine Schuppli , Bentz Mette , Nejad Ayna Baladi , Raffin Estelle , Andersen Kasper Winther , Hulme Oliver James , Siebner Hartwig Roman , Plessen Kerstin Jessica 
Published: September 2023

AbstractBackgroundDespite advances in the etiology of anorexia nervosa (AN), a large subgroup of individuals does not profit optimally from treatment. Perfectionism has been found to be a risk factor predicting the onset, severity, and duration of AN episodes. To date, perfectionism has been studied predominantly by the use of self‐report questionnaires, a useful approach that may, however, be impacted by demand characteristics, or other distortions of introspective or metacognitive access.MethodsHere we circumvent these problems via a behavioral paradigm in which participants perform a modified Go/NoGo task, whilst self‐evaluating their performance. We compared a group of 33 adolescent females during their first episode of AN (age = 16.0) with 29 female controls (age = 16.2), and 23 adolescent girls recovered from AN (age = 18.3) with 23 female controls (age = 18.5). The controls were closely matched by intelligence quotient and age to the two clinical groups.ResultsFirst‐episode AN and control participants performed equally well on the task (reaction time and errors of commission), whereas the recovered group displayed significantly faster reaction times but incurred the same error rate. Despite performing at least as good as and predominantly better than control groups, both clinical groups evaluated their performances more negatively than controls.ConclusionWe offer a novel behavioral method for measuring perfectionism independent of self‐report, and we provide tentative evidence that this behavioral manifestation of perfectionism is evident during first‐episode AN and persists even after recovery.
Interfacial adaptation of NeoMTA Plus, BioRoot RCS and MTA in root‐end cavities: A micro‐CT study
Authors: dos Santos Murilo Mancio , Só Gabriel Barcelos , Siocheta Giovana , Jahnke Leonardo Thomasi , Krabbe Wesley Misael , Pinheiro Lucas Siqueira , Só Marcus Vinicius Reis , da Rosa Ricardo Abreu 
Published: September 2023

AbstractAimThis study aimed to use the micro‐computed tomography to evaluate the interfacial adaptation and the presence of gaps of NeoMTA Plus, BioRoot RCS, and MTA in the root‐end cavities.MethodologyThirty standardized bovine roots measuring 15 mm in length were selected. Chemical–mechanical preparation was performed up to instrument #80 and obturation with the cold lateral compaction technique with cement based on zinc oxide and eugenol. The roots were kept at 37°C for 7 days. Afterward, apicectomy of the apical 3 mm and a root‐end filling cavity was performed at 3 mm depth. Micro‐computed tomography (micro‐CT) was performed to measure the volume of the retroactivity. The roots were divided by stratified randomization into three groups according to the retro‐end filling material: NeoMTA Plus, BioRoot RCS, and MTA. A new micro‐CT was performed to assess the presence of voids in the root‐end filling material and between it and the canal wall. One‐way ANOVA and Tukey tests were performed using the BioEstat 4.0 program.ResultsThere was no difference in the initial volume values of the root‐end cavities (p > .05). After the insertion of root‐end filling materials, the most significant volumes of voids were observed in the NeoMTA Plus group (p < .05), with no difference for the BioRoot RCS and MTA Angelus groups (p > .05).ConclusionMicro‐computed tomography showed that MTA and BioRoot RCS have better interfacial adaptation and presented fewer number of gaps than NeoMTA Plus when used as root‐end filling materials.Research Highlights
Micro‐computed tomography evaluation of different root‐end fillings materials.
Identification of secretory pathway‐related genes based on Random Forest algorithm to predict the prognosis and immunotherapy response of hepatocellular carcinoma
Authors: Wang Zanzhi , Shi Pengwei , Huang Peng , Xu Chun , He Yaoquan , Lei Wenxiong 
Published: September 2023

AbstractBackgroundThe dysfunction of secretory pathways may represent biomarkers or therapeutic targets of cancer. The hepatocellular carcinoma (HCC) phenotype was studied in relation to the genes in the secretory pathway and to screen for a combination of genes that may be a viable therapeutic target for HCC and connected to the pathophysiological features of the tumor.MethodsUsing the HCC information from The Cancer Genome Atlas, somatic mutation and prognostic association analysis were performed on the secretory pathway genes. Based on prognostic genes in the secretory pathway, the samples were consensus clustered, and a Random Forest model was built. The clinical characteristics, tumor mutation burden, functional status and potential responses to immunotherapy and tumor suppressor medications of various subtypes and risk groups were discussed.ResultsOf the 84 genes for secretory pathway, 32 were prognostic genes related to HCC, which divided HCC into two categories: C1 and C2. By comparing the two types of HCC samples, it was found that the survival outcome of C1 was inferior, with stronger adaptive and innate immunity, but less sensitive to immunotherapy than C2. The constructed prognostic signature included seven of the 32 prognostic genes in the secretory pathway, which showed significant correlation with the prognosis, somatic mutation, biological pathway status, potential response to immunotherapy and sensitivity of 72 tumor suppressor drugs from different HCC cohorts, and had a feasible prognostic effect for 31 types of cancer and immunotherapy cohorts.ConclusionsIn this study, HCC was divided into two molecular subtypes according to prognostic genes in the secretory pathway, and seven of them were combined into one signature, which produced significant results in evaluating the prognosis of different HCC cohorts, pan‐cancer cohorts and immunotherapy cohorts, and had potential guiding significance for prophylactic immunotherapy in patients with HCC.
Clinical guideline highlights for the hospitalist: Pediatric direct hospital admission
Authors: Nassetta Lauren B. , Marlin Brittany , Scalici Paul 
Published: September 2023

GUIDELINE TITLE: Direct Admission to the Hospital for Children in the United StatesRELEASE DATE: March 3, 2023PRIOR VERSION(S): n/aDEVELOPER: American Academy of Pediatrics, Committee on Hospital CareFUNDING SOURCE: American Academy of PediatricsTARGET POPULATION: Children who are potential candidates for direct hospital admission
Association of seizure with COVID‐19 vaccines in persons with epilepsy: A systematic review and meta‐analysis
Authors: Rafati Ali , Jameie Melika , Amanollahi Mobina , Jameie Mana , Pasebani Yeganeh , Sakhaei Delaram , Ilkhani Saba , Rashedi Sina , Pasebani Mohammad Yazdan , Azadi Mohammadreza , Rahimlou Mehran , Kwon Churl‐Su 
Published: September 2023

AbstractSeizure aggravation following coronavirus disease 2019 (COVID‐19) vaccines is a major cause behind vaccine hesitancy among persons with epilepsy (PwE), resulting in lower immunization rates. We systematically reviewed seizure‐activity‐related events in PwE following COVID‐19 vaccination. We systematically searched PubMed, Web of Science, Scopus, and Cochrane Library, until January 31, 2023, and included articles reporting seizure activity‐related events in PwE receiving COVID‐19 vaccination. The Preferred Reporting Items for Systematic Reviews and Meta‐Analyses were followed. The protocol was registered with PROSPERO (CRD42022312475). Outcomes included pooled incidence proportions of (a) increased seizure frequency, (b) status epilepticus (SE), and (c) change in seizure type. Of the 2207 studies, 16 entered the meta‐analysis. The pooled incidence proportion of increased seizure frequency (16 studies‐3245 PwE) was 5% (95% CI: 3%−7%, I2 = 52%). Regarding increased seizure frequency, no significant difference was observed between mRNA and viral vector (OR: 1.11, 95% CI: 0.49−2.52, I2 = 0%), and between mRNA and inactivated virus (OR: 1.60, 95% CI: 0.27−9.37; I2 = 0%). The pooled incidence proportion of SE (15 studies‐2387 PwE) was 0.08% (95% CI: 0.02%−0.33%, I2 = 0%). Ultimately, the pooled incidence proportion of change in seizure type (7 studies‐1172 PwE) was 1% (95% CI: 1%−2%, I2 = 0%). The meta‐analysis revealed post‐COVID‐19‐vaccination increased seizure frequency in 5% of PwE, with no difference between mRNA and viral vector or inactivated virus vaccines. Furthermore, we found 0.08% and 1% incidence proportions for postvaccination SE and change in seizure type, respectively. While noteworthy, these values are far less than reports for COVID‐19 infection, emphasizing vaccination importance in preventing COVID‐19 consequences in PwE.
Atypical brain structure and function in young adults exposed to disaster‐related prenatal maternal stress: Project Ice Storm
Authors: Li Xinyuan , Qureshi Muhammad Naveed Iqbal , Laplante David P. , Elgbeili Guillaume , Jones Sherri Lee , Long Xiangyu , Paquin Vincent , Bezgin Gleb , Lussier Firoza , King Suzanne , Rosa‐Neto Pedro 
Published: September 2023

AbstractStudies have shown that prenatal maternal stress (PNMS) affects brain structure and function in childhood. However, less research has examined whether PNMS effects on brain structure and function extend to young adulthood. We recruited women who were pregnant during or within 3 months following the 1998 Quebec ice storm, assessed their PNMS, and prospectively followed‐up their children. T1‐weighted magnetic resonance imaging (MRI) and resting‐state functional MRI were obtained from 19‐year‐old young adults with (n = 39) and without (n = 65) prenatal exposure to the ice storm. We examined between‐group differences in gray matter volume (GMV), surface area (SA), and cortical thickness (CT). We used the brain regions showing between‐group GMV differences as seeds to compare between‐group functional connectivity. Within the Ice Storm group, we examined (1) associations between PNMS and the atypical GMV, SA, CT, and functional connectivity, and (2) moderation by timing of exposure. Primarily, we found that, compared to Controls, the Ice Storm youth had larger GMV and higher functional connectivity of the anterior cingulate cortex, the precuneus, the left occipital pole, and the right hippocampus; they also had larger CT, but not SA, of the left occipital pole. Within the Ice Storm group, maternal subjective distress during preconception and mid‐to‐late pregnancy was associated with atypical left occipital pole CT. These results suggest the long‐lasting impact of disaster‐related PNMS on child brain structure and functional connectivity. Our study also indicates timing‐specific effects of the subjective aspect of PNMS on occipital thickness.
Four typical pulmonary venous pressure curves displaying the level of occlusion during atrial fibrillation ablation by cryoballoon
Authors: Milhem Antoine , Allix‐Béguec Caroline , Laurençon Virginie , Treguer Frédéric , Cesari Olivier 
Published: September 2023

AbstractBackgroundCryoballoon ablation is safe and effective for pulmonary vein isolation in patients with symptomatic drug‐refractory paroxysmal atrial fibrillation. To monitor adhesion between the balloon and the pulmonary vein, an alternative technique to pulmonary venography is to analyze changes in the pressure curve.MethodsWe have described the adhesion level characterized by four types of pressure waveforms.ResultsThese correlated with the extent of contrast agent leakage (Cohen's kappa of 0.81 [IC 95%: 0.63–0.99]).ConclusionMonitoring the venous pressure curve is easy to perform and has the advantage of being able to detect balloon movement during the first few seconds of treatment.
Association between dextrose‐containing maintenance fluids and phosphorus supplementation during total parenteral nutrition initiation in adult patients who were hospitalized: A retrospective cohort study
Authors: Crider Anna , Gillis Christine , Daniels Lauren , Stern Gretchen 
Published: September 2023

AbstractBackgroundUse of dextrose‐containing maintenance fluids prior to parenteral nutrition (PN) initiation is speculated to reduce the risk for refeeding syndrome. We aimed to assess if the use of dextrose vs nondextrose maintenance fluids before PN initiation changes electrolyte supplementation requirements and shifts during initiation.MethodsThis retrospective cohort study included patients who received nothing by mouth but received maintenance fluids ≥72 h before PN. The major end point was phosphorus supplementation over 48 h following nutrition initiation. Minor end point included other electrolyte supplementation, changes in electrolyte levels, time to discharge, and goal kilocalories per day.ResultsFifty‐three patients between August 1, 2019, and August 26, 2020, met criteria for analysis; 60% (n = 32) used a dextrose and 40% (n = 21) used a nondextrose maintenance fluid. Baseline characteristics were similar between fluid groups except for body mass index (25.1 dextrose vs 27.5 kg/m2 nondextrose), sex (43.8% female vs 52.4% male), and severe malnutrition (46.9% vs 28.6%), respectively. Phosphorus (52.5 vs 50 mmol; P = 0.33) and magnesium (24 vs 22 g; P = 0.63) supplementation 48 h following nutrition initiation were similar between groups; however, potassium supplementation was lower in the dextrose group (165.0 vs 208.7 mEq; P = 0.01). No difference was observed between groups for time to discharge following nutrition initiation or time to goal kilocalories per day. After controlling for patients who were malnourished between fluid groups using linear regression, phosphorus repletion differences remained nonsignificant.ConclusionThis study did not detect a difference in phosphorus supplementation between groups, even after controlling for patients who were malnourished.
Hydrogen production through aluminium corrosion in a cement‐based matrix
Authors: Bulidon Nicolas , Pelissier Krystel , Boissy Clément , Mendibide Christophe , Maillot Valérie , Bourbon Xavier , Crusset Didier 
Published: September 2023

AbstractIn France, deep geological disposal is considered for the storage of high and intermediate‐level long‐lived radioactive wastes. For aluminium, the possibility to encapsulate the wastes in a cement‐based matrix is studied. However, cement being an alkaline environment, aluminium can lose its passivity, starts to corrode leading to hydrogen evolution in the infrastructures and generate a possible explosive hazard after decades of storage if hydrogen can accumulate somewhere in the facility. It is therefore necessary to study the corrosion behaviour of aluminium in the different cements considered for the encapsulation to estimate the possible amount of hydrogen that could be generated through corrosion and design the cement capsules accordingly. This work mainly focused on the reaction occurring at the aluminium‐cement interface. Raman spectroscopy did not highlight significant differences in the nature of the corrosion products forming at the cement/aluminium interface, leading to the conclusion that it is not the chemistry of the cement that is the key factor controlling the corrosion rate but rather the physical properties of the cement matrix.