bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Comparison of Outcomes of Standard Weight-Based and Capped Doses of Albumin for Spontaneous Bacterial Peritonitis
Authors: Huang Lily , Marcotte Avery , Murray Taryn S. , Barkes Jordan , Clayton Alissa 
Published: February 2025

Background: Albumin is recommended in the management of patients with spontaneous bacterial peritonitis (SBP) to reduce rates of renal injury and mortality. Current guideline recommendations suggest an intravenous albumin dosing regimen of 1.5 g/kg on day 1 and 1 g/kg on day 3, although a maximum dosing strategy is not well-defined. Objective: The purpose of this study was to evaluate differences in renal injury for patients with SBP treated with a capped dose less than or equal to 100 g vs a weight-based dose greater than 100 g. Methods: A retrospective analysis was conducted at a single academic medical center for patients with a diagnosis of cirrhosis treated with albumin for SBP. The primary outcome examined rates of acute renal injury at 5 days between patients treated with capped dose vs weight-based doses of intravenous albumin. Secondary outcomes included resolution of SBP by day 5, death by day 5, death by day 30, and change in serum creatinine from day 0 to day 5. Results: In total, 258 patient encounters were analyzed, with 154 included in this study. There were 70 encounters encompassing the capped dose and 84 in the non-capped. Acute renal injury at day 5 was observed in 10% (n = 7) of the capped dosed group and 6% (n = 5) of the non-capped group ( P = 0.381). Conclusion and Relevance: This study did not show a significant difference in outcomes associated with a capped albumin dose at 100 g for SBP. Application of these data may aid in reducing health system and patient costs.
A Pilot Randomized Controlled Trial Evaluating Peer Recovery Coaches for Addiction Recovery Among Indigenous Americans
Authors: Guenzel Nicholas , Zimmerman Lani , Watanabe-Galloway Shinobu , Dai Hongying Daisy , Qiu Fang , McChargue Dennis 
Published: February 2025

Background: Peer recovery coaches (PRCs) have experienced addiction and are trained to help others in recovery. Indigenous American (IA) adult PRCs may fill gaps of culturally specific support in addiction. Aims: The aims were to: (1) evaluate the feasibility of implementing a PRC intervention compared to an attention control group recovering from a substance use disorder, (2) compare PRC and attention control groups on relapses and secondary outcomes, and (3) measure PRC strategies. Methods: In this feasibility trial, we recruited a total of 120 adult IAs with substance use disorders. Ninety participants were randomized to the PRC group which received support from a PRC and 30 to the attention control group which received support from a research nurse. Both groups received weekly support for 12 weeks. Participants completed surveys weekly during the 12-week intervention and then monthly for 3 months. Results: The two groups had similar quantities of alcohol consumed, days of alcohol use, and days of drug use except that the PRC group had fewer days of alcohol use in the first 3 weeks of the intervention phase (2.05 vs. 3.5 days, p = .04). “Support and advocacy” was the most common PRC intervention. PRCs were widely accepted by individuals who completed the program, receiving positive feedback from 79% of participants. Conclusion: This pilot demonstrated that racially concordant PRC services likely have high acceptability among IA populations. Future studies may draw on these findings by having trained IA coaches recruit and work with individuals in-person to assist with retention.
C. G. Jung’s Concept of “Manic Mood” From 1904: An Early Contribution to the Disorder of the Adult Form of ADHD?
Authors: Müller Steffen , Strauß Maria , Steinberg Holger 
Published: February 2025

Background: Adult ADHD has increasingly become a focus in adult psychiatry. Despite well-established diagnostic criteria and specific therapeutic approaches, contemporary discussions often dismiss ADHD as a “fad.” This study examines Carl Gustav Jung’s 1904 concept of “manic mood” and its potential alignment with the modern understanding of ADHD in adults. Objective: The aim of this paper is to investigate and discuss whether Jung’s concept of “manic mood” can be considered part of the intellectual history of adult ADHD. Method: Jung’s concept of “manic mood” is analyzed and presented using the literary-historical method of “close reading,” placing the analysis within the context of the early 20th-century discussion of “chronic-manic concepts.” This analysis is compared with the current diagnostic criteria for adult ADHD. Results and Conclusion: Jung’s concept of “manic mood,” described in 1904, has clear parallels to diagnostic criteria used for adult ADHD. It is conceivable that the patients presented by Jung would be diagnosed with adult ADHD today. Jung’s work fits into the discussion of “chronic-manic concepts” of the early 20th century and thus makes a relevant original contribution to the nosological-diagnostic classification of forms in the spectrum of ADHD-affective disorders-personality disorders. The parallel between Jung’s disease construct of “manic mood” and the current view of ADHD supports our hypothesis that the adult form of ADHD represents a consistent disease phenomenon and should therefore not be degraded as a “fad.”
Knowledge and practices of emergency contraception use and associated factors among female undergraduate students in Northern Uganda: A cross-sectional study
Authors: Acen Barbra Kelly , Obonyo Isaac , Ocen Tonny , Arebo Benedict , Auma Anna Grace , Beja Humphrey 
Published: February 2025

Background: Emergency contraception (EC) can prevent up to 95% of unplanned pregnancies if used correctly. Despite efforts to enhance its accessibility, cost and cultural stigmas persist as formidable barriers. Objective: This study assessed the knowledge and practices of EC use and determined the associated factors among the female undergraduate students of Northern Uganda. Design: This was a descriptive, institutional-based cross-sectional study conducted among the female undergraduate students of Lira University in Northern Uganda. Methods: Data were collected from 328 female undergraduates who were surveyed using self-administered questionnaires after obtaining informed consent from them. Data were analyzed using Statistical Package for Social Sciences (SPSS) and presented as frequencies and percentages, and binary and multiple logistic regressions were used to determine the association between the outcome variable and the independent variables. Results were presented as odds ratios with 95% confidence intervals, and associations were considered statistically significant at p ⩽ 0.05. Results: The response proportion was 328/334 (98%). Majority of the participants were 18–23 years old (233/328; 71.0%), had a consistent sexual partner (221/328; 67.4%), and unmarried (206/328; 62.8%). Almost all the participants (315/328; 96%) had heard about EC, where 150/328 (45.7%) learned about EC from health professionals and 135/328 (41.2%) learned about EC from family members and friends. The most well-known brand of EC was Postinor-2 (Levonorgestrel), as reported by 130/328(39.6%) participants. Of the study participants, 200/328 (61.0%) were knowledgeable about the correct timing of EC. Regarding practices of EC use, 214/328 (65.2%) used EC, of whom 122/214 (57.0%) acquired EC from the pharmacy, and most of the participants who had used EC used Postinor-2 (92/214; 43.0%). Of those who used EC, 175/214 (81.8%) used it to prevent unplanned pregnancy, and 182/214 (85.0%) participants used it with the correct timing. The factors that were associated with EC use were being a student who was studying at the Faculty of Health Sciences (adjusted odds ratio (AOR): 4.27, CI: 1.61, 10.09, p ⩽ 0.003) and the absence of a consistent current sexual partner (AOR: 8.63, CI: 4.49, 16.59, p ⩽ 0.00). Conclusion: Participants showed good EC knowledge and usage, but gaps persist. Factors like being a student who was studying at the Faculty of Health Sciences, and lack of a consistent current sexual partner correlated with EC use. Consistent education efforts are needed to address knowledge gaps, focusing on diverse EC forms, reliable information, and affordability. Registration: Not applicable.
Perioperative management of the patient on cannabis and cannabinoids: A review
Authors: Scheuermann Maria , Hans Guy , Wildemeersch Davina 
Published: February 2025

Background: The rise in global cannabis use has led anaesthetists to encounter an increasing number of patients on cannabis and cannabinoids. With cannabis influencing the perioperative period, anaesthetists will face associated challenges managing these patients. Objective: This review aims to summarise this literature on perioperative care for patients with long-term cannabis consumption or cannabis use disorder. Methods: This review was conducted based on the PRISMA 2020 statement. A literature search was performed using Medline and Cochrane library databases to identify relevant reports published from 2003 to 2023. This search yielded 209 records. After screening, 17 articles were included. Results: Preoperative screening of patients for chronic cannabis use or cannabis use disorder can be valuable, due to the increased risk of postoperative myocardial infarction, more postoperative pain and opioid use. Moreover, regarding respiratory management, anaesthetists should prepare to manage bronchospasm and consider adjustments in ventilation. During the perioperative period, attention should be paid to potential interactions between anticoagulant medications and cannabinoids.
ChatGPT Achieves Only Fair Agreement with ACFAS Expert Panelist Clinical Consensus Statements
Authors: Casciato Dominick J. , Calhoun Joshua 
Published: February 2025

Introduction As artificial intelligence (AI) becomes increasingly integrated into medicine and surgery, its applications are expanding rapidly—from aiding clinical documentation to providing patient information. However, its role in medical decision-making remains uncertain. This study evaluates an AI language model’s alignment with clinical consensus statements in foot and ankle surgery. Methods Clinical consensus statements from the American College of Foot and Ankle Surgeons (ACFAS; 2015-2022) were collected and rated by ChatGPT-o1 as being inappropriate, neither appropriate nor inappropriate, and appropriate. Ten repetitions of the statements were entered into ChatGPT-o1 in a random order, and the model was prompted to assign a corresponding rating. The AI-generated scores were compared to the expert panel’s ratings, and intra-rater analysis was performed. Results The analysis of 9 clinical consensus documents and 129 statements revealed an overall Cohen’s kappa of 0.29 (95% CI: 0.12, 0.46), indicating fair alignment between expert panelists and ChatGPT. Overall, ankle arthritis and heel pain showed the highest concordance at 100%, while flatfoot exhibited the lowest agreement at 25%, reflecting variability between ChatGPT and expert panelists. Among the ChatGPT ratings, Cohen’s kappa values ranged from 0.41 to 0.92, highlighting variability in internal reliability across topics. Conclusion ChatGPT achieved overall fair agreement and demonstrated variable consistency when repetitively rating ACFAS expert panel clinical practice guidelines representing a variety of topics. These data reflect the need for further study of the causes, impacts, and solutions for this disparity between intelligence and human intelligence. Level of Evidence: Level IV: Retrospective cohort study
Promoting Adherence to a Yoga Intervention for Veterans With Chronic Low Back Pain
Authors: Gonzalez Carol , Chang Douglas G. , Rutledge Thomas , Groessl Erik J. 
Published: February 2025

Background Research demonstrates that yoga can be effective for improving chronic low back pain (cLBP) among military veterans and non-veterans. Attendance of yoga interventions is necessary to obtain benefits, yet yoga class attendance can be a challenge both within and outside of research, especially for persons who lack resources. Objective Our objective was to describe efforts to boost attendance within a randomized trial of yoga for cLBP, and to examine factors related to attendance. Methods A previous trial of yoga for cLBP among military veterans randomly assigned participants to 2x weekly yoga for 12 weeks, or delayed treatment. After the second of 6 intervention cohorts, efforts were made to improve participant attendance. Attendance and reasons for missing yoga sessions were tracked using sign-in logs and phone calls. Regression analysis was used to examine factors related to attendance. Results After efforts to boost attendance, mean attendance increased from 10.2/24 sessions, (42% attending at least half of sessions), to 13.3/24 sessions, (df (1,74), t = −1.44; P = 0.15) (59% attending half of the sessions). The most common reasons for non-attendance were transportation, financial problems, other health issues, and work or school conflicts. Living status and back pain-related disability at baseline were significantly associated with attendance ( P= < .001 and P = .038 respectively). When including all participants, yoga session attendance was significantly associated with reduced pain severity ( P = 0.01). Conclusions Efforts to boost attendance appeared meaningful but the changes were not statistically significant. Attendance rate in later cohorts were comparable to those in other studies. Reasons provided for non-attendance by participants, and the regression results suggest that resources such as transportation, a stable living situation, and disability levels at baseline were related to attendance rates for this in-person intervention. Remotely delivered yoga may address some of these barriers but hybrid interventions that bring in-person yoga closer to participants may be the best option.
Differences in sleep EEG coherence and spindle metrics in toddlers with and without receptive/expressive language delay: a prospective observational study
Authors: Hong Xinyi , Farmer Cristan , Kozhemiako Nataliia , Holmes Gregory L. , Thompson Lauren , Manwaring Stacy , Thurm Audrey , Buckley Ashura 
Published: February 2025

Abstract

Background
Changes in brain connectivity during development are thought to reflect organizational and maturational processes that correspond to skill acquisition in domains like motor, language, and cognition. This theory is supported by findings in typically developing children as well as observations of abnormal connectivity among children with neurodevelopmental differences. However, few coherence studies have capitalized on the potential of sleep electroencephalogram (EEG) to examine the developing brain, especially among very young children for whom formal neurodevelopmental diagnosis is not yet possible. Sleep microarchitecture in young children may offer key insights into neurophysiological abnormalities associated with neurodevelopmental trajectories and potentially aid in early detection and intervention. In this study, we explored sleep EEG coherence and sleep spindles in typically developing toddlers and toddlers at increased risk of later neurodevelopmental diagnoses.

Methods
We investigated EEG coherence and sleep spindles in 16 toddlers with receptive and expressive language delay (LangD) and 39 typically developing (TD) toddlers. Participants were aged 12–22 months at baseline, and 34 (LangD, n=11; TD, n=23) participants were evaluated again at 36 months of age.

Results
Average EEG coherence was stronger in the LangD group than the TD group, with differences most prominent during slow-wave sleep. Some age-related increases in coherence were observed, but these did not differ between groups. Sleep spindle density, duration, and frequency changed between baseline and follow-up for both groups, with the LangD group demonstrating a smaller magnitude of change than the TD group. The direction of change was frequency band-dependent for both groups.

Conclusions
These findings indicate that atypical sleep EEG connectivity and sleep spindle development can be detected in toddlers at risk of later neurodevelopmental diagnoses.

Trial registration

https://clinicaltrials.gov/study/NCT01339767; Registration date: 4/20/2011.
Genome-wide identification and analysis of the UBA2 gene family in wheat (Triticum aestivum L.)
Authors: Li Juan , Cui Chunge , Han Fengying , Liu Jin 
Published: February 2025

Abstract

Background
RNA-binding proteins (RBPs) participate in multiple aspects of RNA metabolism, which in turn regulates gene expression, thereby involving in organism growth and development. The UBA2 family, one of the subfamilies of RBPs, has been identified in several plant species. However, few researches have been performed to investigate the role of UBA2 in wheat (Triticum aestivum).

Results
In this study, we identified eleven TaUBA2s and divided them into three groups according to their domain characteristics. Phylogenetic analysis was conducted to forecast functional similarities among Arabidopsis, rice, maize and wheat UBA2 genes. Members within the same subfamily of TaUBA2 are relatively conserved in terms of protein structure, motifs, and gene structure. Chromosomal location and synteny analysis suggested that the segmental duplication events played important roles during TaUBA2s evolution. The cis-acting element analysis showed that TaUBA2s were involved in hormone response, development, light response, metabolism, and response to environmental stress. Furthermore, TaUBA2C contains two RNA recognition motifs (RRMs), and the first RRM is responsible for the nuclear speckle formation of TaUBA2C, whereas the two RRMs are necessary for its biological function.

Conclusions
Taken together, our study provides a comprehensive analysis of the TaUBA2 family in wheat and lays the foundation for the future functional investigations of TaUBA2s in wheat growth, development and stress responses.
Genome-wide association analysis reveals the function of DgSAUR71 in plant height improvement
Authors: Xu Xiaoheng , Feng Guangyan , Li Peng , Yu Shuai , Hao Feixiang , Nie Gang , Huang Linkai , Zhang Xinquan 
Published: February 2025

Abstract

Background
Orchardgrass (Dactylis glomerata L.) is one of the four most economically important forage grasses cultivated globally and serves as an excellent perennial forage with high ecological value. Plant height is a key determinant of both biomass and grain yield. While numerous genes regulating plant height have been identified in annual crops, no such genes have been reported for orchardgrass.

Results
In this study, we analyzed the relationship between plant height and biomass yield in a natural population of 264 orchardgrass genotypes and found that a plant height of 90–110 cm contributed to the maximum biomass yield. Genome-wide association analysis (GWAS) identified 23 candidate loci associated with plant height, corresponding to 62 candidate genes. Among these, DgSAUR71, a member of the small auxin-up RNA (SAUR) gene family, emerged as a novel candidate gene associated with plant height. Functional analysis revealed that DgSAUR71 slightly reduced plant height in rice (Oryza sativa L.) and was involved in regulating plant height in orchardgrass.

Conclusions
This study demonstrates that plant height is an important contributor for optimizing biomass yield in orchardgrass, with an optimal range identified. DgSAUR71 was identified as a gene associated with plant height through GWAS and shown to negatively regulate plant height. These findings provide new insights into plant height regulation in orchardgrass and contribute to advancing crop height diversification research.
Evolution of morphological traits of Dendrobium sensu lato (Orchidaceae)—an attempt to resolve phylogenetic relationships in nominal and morphologically convergent sections
Authors: Burzacka-Hinz Aleksandra , Dudek Magdalena , Olędrzyńska Natalia , Naczk Aleksandra M. , Szlachetko Dariusz L. 
Published: February 2025

Abstract

Background

Dendrobium is a large genus within the Orchidaceae family, containing over 1,600 species. Most are sympodial epiphytes. These species are distributed throughout southern, eastern, and southeastern Asia, the Pacific Islands, Australia, New Guinea, and New Zealand. Infrageneric classification of this group is challenging, largely because of the large number of taxa, the wide geographic range, and the considerable morphological diversity. The primary objective of our research was to analyze the genus Dendrobium (focusing primarily on the nominal section) using DNA sequences and to integrate these findings with morphological data.

Results
UPGMA morphological analysis and SIMPER analysis, considering 14 characters, showed that characters such as the placement of the inflorescence, the pseudobulbs from which the inflorescence grows, the surface of the lip, and the number of lobes on the lip are the distinguishing characters of the taxa within Dendrobium sensu lato.The nominal section, Stachyobium, and Formosae (species-rich) are more morphologically variable and exhibit a wide range of variability, in contrast to sections with fewer species. The reconstruction of the ancestral states of Dendrobium sensu lato showed that most of the characters examined arose independently several times during evolution. The only exception is dorsiventrally compressed leaves, a character that arose only once. In addition, the nominal section is not monophyletic and is not entirely consistent with morphology, and species of Holochrysa, Breviflores and Stuposa are closely related.

Conclusion
We conclude that convergent evolution likely occurred among Dendrobium sensu lato representatives, and that many floral traits may have resulted from adaptations to pollinators. This has led to numerous classification problems within the genus. We have not received a clear answer to the question of how to classify species across the genus. Therefore, in this study, we focused primarily on the nominal section.
Integrating fractional-order SEI1I2I3QCR model with awareness and non-pharmaceutical interventions for optimal COVID-19 pandemic
Authors: Refaie Ali Ahmed , Rehman Daniyal Ur , Khan Najeeb Alam , Ayaz Muhammad , Ara Asmat , Khan M. Ijaz 
Published: February 2025

Abstract
Infectious diseases like COVID-19 continue to pose critical challenges globally, underscoring the need for effective control strategies that go beyond traditional vaccinations and treatments. This study introduces an advanced SEI1I2I3QCR model, uniquely incorporating fractional-order delay differential equations to account for latency periods and dynamic transmission patterns of COVID-19, improving accuracy in capturing disease progression and peak oscillations. Stability analyses of the model reveal the critical role of delay and fractional order parameters in managing disease dynamics. Additionally, we applied optimal control theory to simulate non-pharmaceutical interventions, such as quarantine and awareness campaigns, demonstrating a notable reduction in infection rates. Numerical simulations align the model closely with real-world COVID-19 data from China, validating its utility in guiding pandemic response strategies. Our findings emphasize the significance of integrating time-delay factors and fractional calculus in epidemic modeling, offering a novel framework for pandemic management through targeted, cost-effective control measures.