bluuebunny/crossref_metadata_2025_split huggingface dataset:
Estoque de carbono em frações granulométricas da matéria orgânica do solo sob diferentes sistemas de uso na Amazônia oriental
Authors: Souza Alcione Santos de , Kato Osvaldo Ryohei , Freitas Luis de Souza , Galvão Jessivaldo Rodrigues 
Published: April 2023

O estudo da matéria orgânica em seus diversos compartimentos, bem como sua relação com o manejo do sistema ou da terra, visa desenvolver estratégias do ecossistema para utilização sustentável dos solos, com vistas a reduzir o impacto das atividades agrícolas sobre o ambiente. O fracionamento granulométrico permite o estudo dos compartimentos mais humificados e tipicamente mais estáveis às mudanças no ambiente do solo, provocados pelo manejo. O objetivo deste estudo foi avaliar e quantificar o estoque de carbono em frações granulométricas da matéria orgânica do solo sob diferentes sistemas de uso na Amazônia Oriental. O estudo foi realizado na Amazônia Oriental, no município de Igarapé-Açu, em solo classificado como Latossolo Amarelo. As áreas experimentais situadas nas comunidades de Cumaru (Travessa Cumaru), Nova Olinda (em propriedades de pequenos produtores rurais) e UFRA- FEIGA. Os sistemas de uso consistem T1 CC (Cumaru Capoeira), T2 CSQT (Cumaru sem queima triturado), T3 CQ (Cumaru queima), T4 UFC (UFRA Capoeira), T5 UFSQT (UFRA sem queima triturado), T6UFQ (UFRA queima), SAF 1 CT (SAF Capoeira Plantio), SAF 1 PT (SAF plantio triturado), SAF 2 C (SAF Capoeira) SAF 2 QP (SAF queimado e plantio). Foram coletadas amostras de solos nas profundidades 0-5, 5-10 e 10-20 cm. Foram separadas as frações densimétricas (leve livre e leve oclusa) para a determinação de teores de carbono por combustão em analisador elementar LECO CHN-S TRUSTEC. As variáveis estudadas foram submetidas à análise de variância e as medias foram comparadas pelo teste de SNK. Foi utilizado o programa estatístico SISVAR (Ferreira, 2007). O sistema T3 UFC (UFRA capoeira) apresentou uma maior concentração em função da textura areno-argilosa desta área tenha proporcionado esta concentração, o manejo da área, sem revolvimento do solo, a resíduos vegetais no solo provenientes da Capoeira, o que ajuda a manter a matéria orgânica no solo e ciclagem dos nutrientes. A contribuição da fração S+A se destacou na concentração e estoque de carbono total.
Importância da unidade básica de saúde nos estabelecimentos prisionais
Authors: Santos Douglas Vargas dos , Claudino Wendel Oroski , Gonçalves Roberto Leonardo , Puerari Rodrigo , Pola Paula dos Santos 
Published: April 2023

Este estudo teve o objetivo de fomentar o debate sobre o sistema de saúde nos presídios brasileiros, destacando sua importância e seus desafios. A metodologia utilizada foi à pesquisa qualitativa, tendo como coleta de dados o levantamento bibliográfico. As conclusões mais relevantes são questões inerentes a saúde vem sendo negligenciadas no sistema penitenciário brasileiro, motivadas por uma série de deficiências estruturais, entre elas: superlotação, ausência de estruturas mínimas para atendimentos clínicos, bem como de unidades de saúde permanente. Através da revisão de literatura verificou-se que embora existam políticas públicas voltadas à questão, ainda são insuficientes frente a demanda populacional extensa e as condições inadequadas dos presídios que não apenas podem agravar certos quadros clínicos, como ser a própria causa que deu início a doença. Com vistas a criar condições adequadas de saúde e assistência médica é preciso que as políticas públicas de saúde fomentem a incorporação, nas unidades de saúde dos presídios brasileiros, de um ambiente saudável e uma cultura de assistência e reabilitação; além de atendimento adequadamente supervisionado, incluindo atendimento social básico para prisioneiros.
Pengaruh Kepemilikan Kas, Rasio Pengungkit Dan Margin Laba Bersih Terhadap Perataan Laba
Authors: Khamislihi Laysa , Tama Annafi Indra 
Published: April 2023

Tujuan dilakukannya penelitian ini yaitu untuk untuk melakukan pengujian terhadap pengaruh antara kepemilikan kas, rasio pengungkit dan margin laba bersih dengan perataan laba. Penelitian ini menggunakan metode statistic dengan jenis penelitian yaitu kuantitatif. Metode pengambilan sampel dalam penelitian ini yaitu purposive sampling dengan sumber data dari laporan konsolidasian perusahaan yang termasuk didalam kelompok manufaktur bidang industri barang konsumsi. erode penelitian yang digunakan yaitu mulai dari tahun 2017 sampai dengan tahun 2019 . Jumlah sampel yang digunakan setiap periodenya yaitu 24 sampel perusahaan, maka diperoleh 72 sampel seluruh periode dalam penelitian ini. Analisis data dilakukan dengan model analisis regresi logistik dan diolah dengan batuan software SPSS (Statistical Product and Service Solution) versi 25. Hasil penelitian ini menunjukan bahwa Kepemilikan Kas, Rasio Pengungkit dan net profit margin tidak berpengaruh terhadap Perataan Laba.
LncRNAs signatures associated with cuproptosis predict the prognosis of endometrial cancer
Authors: Qi Shiyuan , Feng Huiyan , Li Xiaomao 
Published: April 2023

Background: Endometrial cancer (UCEC) is the sixth most common cancer in women, and although surgery can provide a good prognosis for early-stage patients, the 5-year overall survival rate for women with metastatic disease is as low as 16%. Long non-coding RNAs (LncRNAs) are thought to play an important role in tumor progression. Cuproptosis is a recently discovered form of cell death in which copper binds directly to the lipoacylated component of the tricarboxylic acid (TCA) cycle. The aggregation of these copper-bound listed mitochondrial proteins and the loss of Fe-S cluster proteins trigger proteotoxic stress, which leads to cell death. Therefore, the aim of this work was to investigate the role of Cuproptosis-related LncRNAs signaling in clinical prognostic prediction and immunotherapy, as well as the relationship between tumor mutation burden.Methods: Genomic, clinical and mutational data of endometrial cancer patients were presented in the TCGA database, and cuproptosis-related genes obtained from related studies. Coexpression analysis and Cox regression analysis were used to construct prognostic features. Patients were divided into high risk group and low risk group, and then ROC, survival rate, risk curve, principal component analysis, independent prognostic analysis and clinical subgroup model validation were performed to observe the prognostic value of characteristics. Subsequently, the GO and genomic KEGG enrichment and immune-related functions of LncRNAs as well as the tumor mutation burden were analyzed.Results: In 548 UCEC case data, we identified five associated LncRNAs co-expressed with cuproptosis genes, and we found that high-risk patients had poorer overall survival (OS), progression-free survival (PFS), and higher mortality. Independent prognostic analysis, ROC showed that the LncRNAs associated with cuproptosis could accurately predict the prognosis of patients. Enrichment analysis revealed that the biological functions of LncRNAs were related to tumorigenesis. We also discovered suppression of immune-related functions in high-risk patients with oncogene mutations, higher tumor mutation burden in low-risk patients, and longer overall survival in patients with higher tumor mutation burden.Conclusion: The identification of five LncRNAs associated with cuproptosis can accurately predict the prognosis of patients with endometrial cancer, and may provide a new perspective for clinical application and immunotherapy.
Decreased mannan-binding lectin level in adults with hypopituitarism; dependence on appropriate hormone replacement therapies
Authors: Matusiak Aleksandra E. , Stępniak Jan , Lewiński Andrzej , Karbownik-Lewińska Małgorzata 
Published: April 2023

BackgroundMannan-binding lectin (MBL) is a main component of the lectin pathway of the complement system. Although there are some studies showing links between endocrine and immune systems, the ones concerning hypopituitarism are limited. The aim of this study was to check whether there is any association between blood MBL level and pituitary hormone deficiencies and whether this relationship is affected by appropriate hormone replacement therapies.MethodsOne hundred and twenty (120) inpatients, aged 18-92, were divided into two main groups, i.e. control individuals (21/120) and patients with pituitary diseases (99/120). The latter were diagnosed either with hypopituitarism (n=42) or with other pituitary diseases (not causing hypopituitarism) (n=57). Additionally, hypopituitary patients on appropriate replacement therapies (compensated hypopituitarism) were compared to patients on inappropriate replacement therapies (non-compensated hypopituitarism). Several parameters in blood serum were measured, including MBL level, pituitary and peripheral hormones and different biochemical parameters.ResultsSerum MBL level was significantly lower in patients with hypopituitarism comparing to controls (1358.97 ± 244.68 vs. 3199.30 ± 508.46, p&lt;0.001) and comparing to other pituitary diseases (1358.97 ± 244.68 vs. 2388.12 ± 294.99, p=0.015) and this association was confirmed by univariate regression analysis. We evaluated the distribution of patients with relation to MBL level; there was a clear difference in this distribution between control individuals (among whom no subjects had MBL level &lt;500 ng/mL) and patients with hypopituitarism (among whom 43% of patients had MBL level &lt;500 ng/mL). Moreover, patients with non-compensated hypopituitarism had lower mean and median MBL levels comparing to patients with compensated hypopituitarism (1055.38 ± 245.73 vs. 2300.09 ± 579.93, p=0.027; 488.51 vs. 1951.89, p=0.009, respectively) and this association was confirmed in univariate regression analysis. However, mean and median MBL levels in patients with compensated hypopituitarism vs. controls did not differ significantly (2300.09 ± 579.93 vs. 3199.30 ± 508.46, p=0.294; 1951.90 vs. 2329.16; p=0.301, respectively).ConclusionHypopituitarism in adults is associated with a decreased blood concentration of mannan-binding lectin, a phenomenon which does not exist in hypopituitary patients on the appropriate hormone replacement therapies. Therefore measurement of mannan-binding lectin level in patients with hypopituitarism may be considered as a parameter contributing to adjust optimal doses of hormone replacement therapies.
Remission outcomes in severe eosinophilic asthma with mepolizumab therapy: Analysis of the REDES study
Authors: Pavord Ian , Gardiner Frances , Heaney Liam G. , Domingo Christian , Price Robert G. , Pullan Alison , Oppenheimer John , Brusselle Guy , Nagase Hiroyuki , Chupp Geoffrey , Pizzichini Emilio , Bañas-Conejero David , Howarth Peter 
Published: April 2023

IntroductionClinical remission as a multicomponent treatment goal in severe asthma is being explored in clinical practice. This post hoc analysis used data from the REDES study to assess the proportion of patients with severe eosinophilic asthma achieving our multicomponent definitions of clinical remission after 1 year of mepolizumab treatment.MethodsThe real-world, retrospective observational REDES study enrolled patients with severe eosinophilic asthma who were newly prescribed mepolizumab and with ≥12 months of medical records pre-enrolment. Multicomponent clinical remission was defined as: oral corticosteroid (OCS)-free; exacerbation-free; asthma control test (ACT) score ≥20; and with or without post-bronchodilator forced expiratory volume in 1 second ≥80%. Baseline characteristics were also assessed in those who did/did not achieve clinical remission.Results37% and 30% of patients with severe eosinophilic asthma met our proposed three- and four-component on-treatment clinical remission definitions; an increase from 2% and 3% at baseline. Most frequently achieved individual components of clinical remission were: OCS-free; ACT score ≥20. For patients fulfilling the multicomponent clinical remission definitions, at baseline we observed higher blood eosinophil counts, better ACT scores and lung function, lower maintenance OCS use, and a slightly lower rate of prior exacerbations versus those who did not.DiscussionClinical remission is a realistic target in clinical practice for a subset of patients with severe eosinophilic asthma receiving mepolizumab. Further studies are required to elucidate whether features linked to the underlying endotype can help predict treatment outcomes, increase rates of clinical remission, and potentially modify disease progression.
Heterogeneity of glycan biomarker clusters as an indicator of recurrence in pancreatic cancer
Authors: Wisniewski Luke , Braak Samuel , Klamer Zachary , Gao ChongFeng , Shi Chanjuan , Allen Peter , Haab Brian B. 
Published: April 2023

IntroductionOutcomes following tumor resection vary dramatically among patients with pancreatic ductal adenocarcinoma (PDAC). A challenge in defining predictive biomarkers is to discern within the complex tumor tissue the specific subpopulations and relationships that drive recurrence. Multiplexed immunofluorescence is valuable for such studies when supplied with markers of relevant subpopulations and analysis methods to sort out the intra-tumor relationships that are informative of tumor behavior. We hypothesized that the glycan biomarkers CA19-9 and STRA, which detect separate subpopulations of cancer cells, define intra-tumoral features associated with recurrence.MethodsWe probed this question using automated signal thresholding and spatial cluster analysis applied to the immunofluorescence images of the STRA and CA19-9 glycan biomarkers in whole-block sections of PDAC tumors collected from curative resections.ResultsThe tumors (N = 22) displayed extreme diversity between them in the amounts of the glycans and in the levels of spatial clustering, but neither the amounts nor the clusters of the individual and combined glycans associated with recurrence. The combined glycans, however, marked divergent types of spatial clusters, alternatively only STRA, only CA19-9, or both. The co-occurrence of more than one cluster type within a tumor associated significantly with disease recurrence, in contrast to the independent occurrence of each type of cluster. In addition, intra-tumoral regions with heterogeneity in biomarker clusters spatially aligned with pathology-confirmed cancer cells, whereas regions with homogeneous biomarker clusters aligned with various non-cancer cells.ConclusionThus, the STRA and CA19-9 glycans are markers of distinct and co-occurring subpopulations of cancer cells that in combination are associated with recurrence. Furthermore, automated signal thresholding and spatial clustering provides a tool for quantifying intra-tumoral subpopulations that are informative of outcome.
The relationships among Taiwanese youth’s polychronicity, multitasking behavior and perceived learning performance in online learning
Authors: Luo Yi Fang , Kang Seokmin , Yang Shu Ching , Lu Chia Mei 
Published: April 2023

BackgroundThe advancement of digital technology implies the importance of polychronic learning. Since polychronicity is not equivalent to multitasking behavior, they need to be considered separately. However, less research has been explored on how polychronicity is related to multitasking behavior in the educational field.ObjectiveTo explore the relationships among polychronicity, multitasking behavior and learning performance (including knowledge acquisition and learning satisfaction) in an online learning environment.MethodsThe relationship among variables was analyzed from 865 responses obtained from a questionnaire survey, and independent sample t tests and SEM analysis were used to examine the research hypotheses.ResultsCollege students showed a higher frequency of multitasking behavior, time tangibility and scheduling preference, and learning satisfaction in multitasking online learning environments than high school students. Additionally, college students were different from high school students on the paths of involvement with people to multitasking behavior (Δ χ2= 5.42, p = 0.02) and scheduling preference to learning satisfaction (Δχ2 = 9.54, p = 0.002).ConclusionThe relationship among polychronicity, multitasking behavior and perceived learning performance in an online learning environment varies by student educational stage.
Does inclusive leadership affect the organizational socialization of newcomers from diverse backgrounds? The mediating role of psychological capital
Authors: Dai Xinxing , Fang Yangchun 
Published: April 2023

IntroductionThis paper aims to explore the influence of inclusive leadership on the organizational socialization of newcomers from diverse backgrounds, as mediated by psychological capital.MethodsStructural equation model was used by Mplus 8.3 to analyze the effect of inclusive leadership and psychological capital on organizational socialization. This study used the 1,000 bootstrap replications method and the mediating path effect test to find out the mediating effect of psychological capital between the relationship of inclusive leadership and organizational socialization.ResultsThe result found that (1) inclusive leadership positively affects newcomers’ organizational culture, interpersonal relationships,socialization into organizational politics and can improve employees’ job competence. (2) Psychological capital plays an intermediary role between inclusive leadership and the organizational culture, interpersonal relationships and socialization into organizational politics and job competence. Inclusive leaders improve newcomers’ psychological capital by encouraging and recognizing their diversity, tolerating their mistakes. It can increase new generation of newcomers’ resilience, self-efficacy and optimism. Individuals with high psychological capital are more likely to integrate into the organizational culture and increase their interaction with colleagues and then are more likely to integrate into the organization.DiscussionOrganizations should encourage leaders to develop inclusive leadership behaviors to foster newcomer socialization. In an inclusive leadership context, newcomers have high levels of psychological capital that promote their organizational socialization. Inclusive leadership is crucial for helping newcomers from diverse backgrounds to integrate into organizations.
The effect of garden use on quality of life and behavioral and psychological symptoms of dementia in people living with dementia in nursing homes: a systematic review
Authors: Velde-van Buuringen Melanie van der , Hendriks-van der Sar Rosalie , Verbeek Hilde , Achterberg Wilco P. , Caljouw Monique A. A. 
Published: April 2023

ObjectivesConsidering the importance of going outside in a natural environment for people in general, and people living with dementia in particular, we want to unravel the aspects by which garden use affects quality of life (QoL) and behavioral and psychological symptoms of dementia (BPSD) in people living with dementia in nursing homes.DesignSystematic review.Setting and participantsPeople living with dementia in nursing homes.MethodsThis systematic review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Eight electronic bibliographic databases were searched (May 2022). Quantitative, qualitative and mixed-methods studies describing the effect of garden use on QoL, BPSD, or other outcomes related to QoL or BPSD in people living with dementia in nursing homes were included. The methodological quality of individual studies was assessed with the Mixed Methods Appraisal Tool (MMAT) and a narrative synthesis of the results was performed.ResultsAfter screening title and abstract (N = 498), and full-text assessment (N = 67), 19 publications were included. These described 17 studies and three types of interventions: (1) interventions regarding the evaluation of effects of specifically designed nursing home gardens, (2) participation of the people living with dementia in outside activities, and (3) other interventions, for example, garden visits and different seasons.Conclusions and implicationsOverall, first studies appear to suggest positive effects of garden use on QoL, BPSD, or other outcomes related to QoL or BPSD (stress, sleep, and mood) in people living with dementia in nursing homes. However, consensus regarding measurements and key outcomes, taking into account the physical, social, and organizational aspects when designing the garden use intervention, is necessary for the reliable evaluation of these interventions.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?RecordID=283267, identifier: CRD42021283267.
Letter From the Editor
Authors: Hoffman Regina 
Published: April 2023

This March marks the 21st Patient Safety Awareness Week, first initiated in 2002 by the National Patient Safety Foundation to invite conversations on how to reduce harm and improve care. In this issue, you will find four articles that originated from the Patient Safety Authority’s fall master class in writing. Applicants submitted a description of a recent quality improvement study and those selected participated in a two-part workshop. The facilitators, Johns Hopkins’ Olivia Lounsbury and Patient Safety editors Caitlyn Allen and Eugene Myers, helped translate tremendous patient care into publishable manuscripts. (Keep an eye out for future workshops!)
Capacidad biosortiva del Nostoc commune en la separación del plomo de aguas contaminadas
Authors: Rojas Felipe Edwin , Sánchez Araujo Víctor Guillermo , Hinojosa Yzarra Lizangela Aurelia , Rivera Trucios Fredy , Rodríguez Deza Jorge Washington 
Published: April 2023

La contaminación del agua por presencia de metales pesados como el plomo, es un problema mundial que ha desequilibrado el sistema de salud en la humanidad, toda vez que este metal afecta la pureza del agua bebible, poniendo en peligro la sobrevivencia de los seres vivos, ya que el plomo afecta los sistemas nervioso, hematológico, cardiovascular y reproductivo; frente a ello, la biosorción, se presenta como un efectivo método alternativo, motivo por el cual el presente estudio tiene el objetivo de dar una visión general y actualizada sobre la capacidad biosortiva del Nostoc commune en la eliminación de plomo de aguas contaminadas. Se realizó la revisión y análisis del estado del arte en sus fases heurística y hermenéutica acerca de la capacidad biosortiva del Nostoc commune, recopilando artículos científicos y tesis relacionados a la biosorción del plomo utilizando descriptores como “biosorción”, “quimiosorción”, “Nostoc commune” “metales pesados”. Se resalta que la capacidad biosortiva está comprendida entre 247,35 y 384,62 mg pb / g de Nostoc commune; y el modelo que describe fue Langmuir (R2) comprendido entre 98,8 y 99,25%; siendo el Nostoc commune un potencial biosorbente altamente eficiente para separar el plomo de aguas contaminadas, a través de grupos carboxilos e hidroxilos, azúcares reductores, saponinas y aminoácidos, concluyendo que, el Nostoc commune tiene alto potencial biosorbente y muy efectivo para contrarrestar la presencia de plomo en el agua.
MENINGKATKAN KEMAMPUAN SISWA SISWA PADA MATERI POKOK ALAT UKUR SATUAN PANJANG MELALUI PENERAPAN METODE DEMONTRASI DAN PEMBERIAN TUGAS
Authors: Narumanah Ema 
Published: April 2023

Penelitian ini bertujuan untuk meningkatkan hasil belajar siswa pada materi Alat Ukur Satuan Panjang melalui penerapan Model Pembelajaran Metode Demontrasi dan Pemberian Tugas pada siswa kelas II SD Negeri Tunas Mulya Kecamatan Sagalaherang Kabupaten Subang semester Genap tahun pelajaran 2018/2019. Subyek penelitian terdiri dari 22 orang siswa yang heterogen. Penelitian ini dilaksanakan dalam 2 siklus sertiap siklus terdiri dari 3 kali pertemuan , pada pertemuan ke 1 dan ke 2 tentang pembahaasan materi pelajaran, sedangkan pertemuan ke 3 dilaksanakan tes formatif. Rata- rata hasil tes formatif siklus 1 adalah 69,75 dan rata- rata hasil tes formatif siklus 2 adalah 81,91. Hasil penelitian ini menunjukan adanya peningkatan nilai rata- rata sebesar 12,24 (17,55%). Dengan demikian pembelajaran Matematika dengan Model Pembelajaran Metode Demontrasi dan Pemberian Tugas dapat meningkatkan motivasi dan hasil belajar siswa.