bluuebunny/crossref_metadata_2025_split huggingface dataset:
Residual anti-Xa activity in plasma of patients presenting for electively planned neuraxial regional anesthesia
Authors: Knoerlein Julian , Brodbeck Philipp , Büchsel Martin , Zieger Barbara , Schmutz Axel 
Published: January 2023

ObjectiveTo determine the incidence of increased anti-Xa activity within plasma levels 24 hours after administration of therapeutic dose low-molecular-weight heparin in patients presenting for elective neuraxial anesthesia.BackgroundGuidelines for neuroaxial regional anesthesia for patients with antithrombotic drugs recommend time intervals for waiting. There is scientific evidence to suggest that the recommended interval of 24 hours may be insufficient in patients treated with therapeutic dose low-molecular-weight heparin.MethodsRetrospective cohort analysis of 74 patients who received therapeutic dose low-molecular-weight heparin before planned neuraxial anesthesia between April 1, 2015 and April 1, 2020 at Freiburg University Hospital. Primary endpoint was the occurrence of elevated plasma anti-Xa levels in prophylactic range or higher (>0.2 IU/mL) 24 hours after the last application of the therapeutic dose.Results24 hours after the last dose of therapeutic low-molecular-weight heparin, 18.0% of patients had elevated anti-Xa activity levels >0.2 IU/mL. A weak correlation between the time since the last administration of low-molecular-weight heparin and plasma anti-Xa levels could be found. No other risk factors were seen.ConclusionsRelevant residual anticoagulant activity, as measured by plasma anti-Xa levels within a prophylactic range, is measurable 24 hours after the last administration of therapeutic dose low-molecular-weight heparin.Trial registration numberGerman Clinical Trials Register DRKS00022099.
Chair's Letter
Authors: Carterette Ben 
Published: January 2023

Dear SIGIR community,
This is my last letter as Chair of the SIGIR Executive Committee. I want to start off by thanking the committee, Tetsuya Sakai (Vice Chair), Min Zhang (Treasurer), Claudia Hauff (Secretary), and Diane Kelly (Past Chair). It has been an honor to work with them to serve the community. We have accomplished a lot---see below---and I look forward to working with the next committee of Vanessa Murdock (Chair), Ryen White (Vice Chair), Carsten Eickhoff (Treasurer), and Laura Dietz (Secretary) to accomplish even more.
Responsible Artificial Intelligence --- From Principles to Practice
Authors: Dignum Virginia 
Published: January 2023

The impact of Artificial Intelligence does not depend only on fundamental research and technological developments, but for a large part on how these systems are introduced into society and used in everyday situations. AI is changing the way we work, live and solve challenges but concerns about fairness, transparency or privacy are also growing. Ensuring responsible, ethical AI is more than designing systems whose result can be trusted. It is about the way we design them, why we design them, and who is involved in designing them. In order to develop and use AI responsibly, we need to work towards technical, societal, institutional and legal methods and tools which provide concrete support to AI practitioners, as well as awareness and training to enable participation of all, to ensure the alignment of AI systems with our societies' principles and values.
This paper is a curated version of my keynote at the Web Conference 2022.
Phase I Study and Cell-Free DNA Analysis of T-DM1 and Metronomic Temozolomide for Secondary Prevention of HER2-Positive Breast Cancer Brain Metastases
Authors: Jenkins Sarah , Zhang Wei , Steinberg Seth M. , Nousome Darryl , Houston Nicole , Wu Xiaolin , Armstrong Terri S. , Burton Eric , Smart Dee Dee , Shah Ritu , Peer Cody J. , Mozarsky Brett , Arisa Oluwatobi , Figg William D. , Mendoza Tito R. , Vera Elizabeth , Brastianos Priscilla , Carter Scott , Gilbert Mark R. , Anders Carey K. , Connolly Roisín M. , Tweed Carol , Smith Karen L. , Khan Imran , Lipkowitz Stanley , Steeg Patricia S. , Zimmer Alexandra S. 
Published: January 2023

AbstractPurpose:Preclinical data showed that prophylactic, low-dose temozolomide (TMZ) significantly prevented breast cancer brain metastasis. We present results of a phase I trial combining T-DM1 with TMZ for the prevention of additional brain metastases after previous occurrence and local treatment in patients with HER2+ breast cancer.Patients and Methods:Eligible patients had HER2+ breast cancer with brain metastases and were within 12 weeks of whole brain radiation therapy (WBRT), stereotactic radiosurgery, and/or surgery. Standard doses of T-DM1 were administered intravenously every 21 days (3.6 mg/kg) and TMZ was given orally daily in a 3+3 phase I dose escalation design at 30, 40, or 50 mg/m2, continuously. DLT period was one 21-day cycle. Primary endpoint was safety and recommended phase II dose. Symptom questionnaires, brain MRI, and systemic CT scans were performed every 6 weeks. Cell-free DNA sequencing was performed on patients’ plasma and CSF.Results:Twelve women enrolled, nine (75%) with prior SRS therapy and three (25%) with prior WBRT. Grade 3 or 4 AEs included thrombocytopenia (1/12), neutropenia (1/12), lymphopenia (6/12), and decreased CD4 (6/12), requiring pentamidine for Pneumocystis jirovecii pneumonia prophylaxis. No DLT was observed. Four patients on the highest TMZ dose underwent dose reductions. At trial entry, 6 of 12 patients had tumor mutations in CSF, indicating ongoing metastatic colonization despite a clear MRI. Median follow-up on study was 9.6 m (2.8–33.9); only 2 patients developed new parenchymal brain metastases. Tumor mutations varied with patient outcome.Conclusions:Metronomic TMZ in combination with standard dose T-DM1 shows low-grade toxicity and potential activity in secondary prevention of HER2+ brain metastases.
In Vivo Dissection of Chamber-Selective Enhancers Reveals Estrogen-Related Receptor as a Regulator of Ventricular Cardiomyocyte Identity
Authors: Cao Yangpo , Zhang Xiaoran , Akerberg Brynn N. , Yuan Haiyun , Sakamoto Tomoya , Xiao Feng , VanDusen Nathan J. , Zhou Pingzhu , Sweat Mason E. , Wang Yi , Prondzynski Maksymilian , Chen Jian , Zhang Yan , Wang Peizhe , Kelly Daniel P. , Pu William T. 
Published: January 2023

Background:Cardiac chamber-selective transcriptional programs underpin the structural and functional differences between atrial and ventricular cardiomyocytes (aCMs and vCMs). The mechanisms responsible for these chamber-selective transcriptional programs remain largely undefined.Methods:We nominated candidate chamber-selective enhancers (CSEs) by determining the genome-wide occupancy of 7 key cardiac transcription factors (GATA4, MEF2A, MEF2C, NKX2-5, SRF, TBX5, TEAD1) and transcriptional coactivator P300 in atria and ventricles. Candidate enhancers were tested using an adeno-associated virus–mediated massively parallel reporter assay. Chromatin features of CSEs were evaluated by performing assay of transposase accessible chromatin sequencing and acetylation of histone H3 at lysine 27-HiChIP on aCMs and vCMs. CSE sequence requirements were determined by systematic tiling mutagenesis of 29 CSEs at 5 bp resolution. Estrogen-related receptor (ERR) function in cardiomyocytes was evaluated by Cre-loxP–mediated inactivation of ERRα and ERRγ in cardiomyocytes.Results:We identified 134 066 and 97 506 regions reproducibly occupied by at least 1 transcription factor or P300, in atria or ventricles, respectively. Enhancer activities of 2639 regions bound by transcription factors or P300 were tested in aCMs and vCMs by adeno-associated virus–mediated massively parallel reporter assay. This identified 1092 active enhancers in aCMs or vCMs. Several overlapped loci associated with cardiovascular disease through genome-wide association studies, and 229 exhibited chamber-selective activity in aCMs or vCMs. Many CSEs exhibited differential chromatin accessibility between aCMs and vCMs, and CSEs were enriched for aCM- or vCM-selective acetylation of histone H3 at lysine 27–anchored loops. Tiling mutagenesis of 29 CSEs identified the binding motif of ERRα/γ as important for ventricular enhancer activity. The requirement of ERRα/γ to activate ventricular CSEs and promote vCM identity was confirmed by loss of the vCM gene profile in ERRα/γ knockout vCMs.Conclusions:We identified 229 CSEs that could be useful research tools or direct therapeutic gene expression. We showed that chamber-selective multi–transcription factor, P300 occupancy, open chromatin, and chromatin looping are predictive features of CSEs. We found that ERRα/γ are essential for maintenance of ventricular identity. Finally, our gene expression, epigenetic, 3-dimensional genome, and enhancer activity atlas provide key resources for future studies of chamber-selective gene regulation.
Towards Immersive Generosity: The Need for a Novel Framework to Explore Large Audiovisual Archives through Embodied Experiences in Immersive Environments
Authors: Alliata Giacomo , Kenderdine Sarah , Hibberd Lily , Mason Ingrid 
Published: January 2023

Abstract
This paper proposes an innovative framework to explore large audiovisual archives using Immersive Environments to place users inside a dataset and create an embodied experience. It starts by outlining the need for such a novel interface to meet the needs of archival scholars and the GLAM sector, and discusses issues in the current modes of access, mostly restrained to traditional information retrieval systems based on metadata. The paper presents the concept of “generous interfaces” as a preliminary approach to address these issues, and argues some of the key reasons why employing Immersive Visual Storytelling might benefit such frameworks. The theory of embodiment is leveraged to justify this claim, showing how a more embodied understanding of a collection can result in a stronger engagement for the public. By placing users as actors in the experience rather than mere spectators, the emergence of narrative is driven by their interactions, with benefits in terms of engagement with the public and understanding of the cultural component. The framework we propose is applied to two existing installations to analyze them in-depth and critique them, highlighting the key directions to pursue for further development.
Interdecadal Variations of the Scandinavian Pattern
Authors: Pang Bo , Scaife Adam A. , Lu Riyu , Ren Rongcai , Zhao Xiaoxuan 
Published: January 2023

Abstract
This study investigates the interdecadal variation of the Scandinavian (SCA) pattern and corresponding drivers during the boreal winter. It is found that the SCA pattern experiences a prominent regime shift from its negative to positive phase in the early 2000s based on several reanalyses. This interdecadal change contributes to an extensive cooling over Siberia after the early 2000s, revealing its importance for recent variations of climate over Eurasia. The outputs from 35 coupled models within phase 6 of the Coupled Model Intercomparison Project (CMIP6) are also analyzed. The results show that the interdecadal change of the SCA is weak in response to external forcings but can be largely explained by internal variability associated with a change of precipitation over the tropical Atlantic. Further analysis indicates that the enhanced tropical convection induces poleward propagation of Rossby waves and further results in an intensification of geopotential height over the Scandinavian Peninsula during the transition to positive SCA phases. These findings imply a contribution of tropical forcing to the observed interdecadal strengthening of the SCA around the early 2000s and offer an insight into the understanding of future climate change over the Eurasian continent.
Nurses' professional commitment in COVID-19 crisis: A qualitative study
Authors: Momeni Maryam , Khatooni Marzieh 
Published: January 2023

Background: Professional commitment is an important factor in employee performance. COVID-19 outbreak has seriously affected the nurses working conditions. Numerous factors can affect nurses' professional commitment in this situation. Aim: To explore the nurses' lived experiences, attitudes, views and perceptions toward professional commitment and factors affecting it in the Covid-19 crisis. Method, Setting and Participants: This qualitative study was conducted using phenomenological approach and content analysis method. Twenty-five nurses were interviewed using semi structured in-depth interviews. Conventional content analysis was used to analyze collected data. Ethical considerations: Ethical approval was obtained from the Ethics Committee of Qazvin University of Medical Sciences. Results: Five themes were extracted as follows: “Collaborative empathetic commitment”, “Loyal commitment”, “Sacrificial commitment”, “Commitment with doubt and concern” and “humanistic commitment”. Discussion and Conclusion: The Covid-19 crisis has caused major changes in nurses' working conditions, which have also affected the concept of professional commitment to the nursing profession and revealed new concepts. Identifying internal and external factors that can enhance nurses' commitment to the profession in critical situations such as the Covid-19 outback is of particular importance.
Estimation of moral distress among nurses: A systematic review and meta-analysis
Authors: Alimoradi Zainab , Jafari Elahe , Lin Chung-Ying , Rajabi Raheleh , Marznaki Zohreh Hosseini , Soodmand Mostafa , Potenza Marc N , Pakpour Amir H 
Published: January 2023

Background Moral distress is a common challenge among professional nurses when caring for their patients, especially when they need to make rapid decisions. Therefore, leaving moral distress unconsidered may jeopardize patient quality of care, safety, and satisfaction. Aim To estimate moral distress among nurses. Methods This systematic review and meta-analysis conducted systematic search in Scopus, PubMed, ProQuest, ISI Web of Knowledge, and PsycInfo up to end of February 2022. Methodological quality of included studies was assessed using the Newcastle Ottawa checklist. Data from included studies were pooled by meta-analysis with random effect model in STATA software version 14. The selected key measure was mean score of moral distress total score with its’ 95% Confidence Interval was reported. Subgroup analyses and meta-regressions were conducted to identify possible sources of heterogeneity and potentially influencing variables on moral distress. Funnel plots and Begg’s Tests were used to assess publication bias. The Jackknife method was used for sensitivity analysis. Ethical consideration The protocol of this project was registered in the PROSPERO database under decree code of CRD42021267773. Results Eighty-six manuscripts with 19,537 participants from 21 countries were included. The pooled estimated mean score of moral distress was 2.55 on a 0–10 scale [95% Confidence Interval: 2.27–2.84, I2: 98.4%, Tau2:0.94]. Publication bias and small study effect was ruled out. Moral distress significantly decreased in the COVID-19 pandemic versus before. Nurses working in developing countries experienced higher level of moral distress compared to their counterparts in developed countries. Nurses' workplace (e.g., hospital ward) was not linked to severity of moral disturbance. Conclusion The results of the study showed a low level of pooled estimated score for moral distress. Although the score of moral distress was not high, nurses working in developing countries reported higher levels of moral distress than those working in developed countries. Therefore, it is necessary that future studies focus on creating a supportive environment in hospitals and medical centers for nurses to reduce moral distress and improve healthcare.
Super-obese patients are associated with significant infection burden after total hip arthroplasty
Authors: Chen Zhongming , Sax Oliver C , Bains Sandeep S , Salib Christopher G , Paulson Ambika E , Verma Ankush , Nace James , Delanois Ronald E 
Published: January 2023

Introduction: Over ⅓ of the population in the United State is obese (body mass index [BMI] >30 kg/m2), with an increasing proportion being morbidly obese (BMI >40 kg/m2). As the obesity rate climbs, an increasing number have entered the super-obese category (BMI >50 kg/m2), theoretically increasing risk for complications after total hip arthroplasty (THA). This study compared complications in non-obese, obese, morbidly obese, and super-obese patients undergoing THA. We specifically assessed: (1) 1- and 2-year peri-prosthetic joint infection (PJI) rates; (2) complication rates; as well as (3) 1- and 2-year revision rates. Methods: A database review identified patients undergoing primary THA from 01 January 2010 to 31 December 2019. Patients were stratified based on the presence of International Classification of Diseases, 9th and 10th revision diagnosis codes of non-obese (BMI <30 kg/m2) ( n  = 8680), obese (BMI <40 kg/m2) ( n  = 12,443), morbidly obese (BMI <50 kg/m2) ( n  = 5250), and super-obese (BMI >50 kg/m2) ( n  = 814) prior to THA. Complication rates at 90 days, 1 year, and 2 years were compared across groups. Results: At all time points, super-obese patients were associated with higher rates of PJI, even when compared to morbidly obese patients. Complications such as sepsis, venous thrombo-embolism, and revision surgeries were found in higher numbers in super-obese as well as morbidly obese patients, compared to obese and non-obese patients. Conclusions: This study provides large-scale analyses demonstrating the association between super-obese and morbidly obese patients and higher infection rates, as well as complications, following THA. Importantly, the association of PJI is highest among super-obese patients, even when compared to morbidly obese patients. Attaining a BMI <40 kg/m2 prior to surgery may be an important goal discussed with patients to lower the chance of postoperative infections.
COVID-19 vaccination improved outcomes in the treatment of geriatric hip fractures between December 2020 and January 2022
Authors: Konda Sanjit R , Meltzer Bruhn Ariana T , Esper Garrett W , Solasz Sara J , Ganta Abhishek , Egol Kenneth A 
Published: January 2023

Introduction: Geriatric hip fracture patients are at high risk for perioperative morbidity and mortality from COVID-19. This study analyses the impact of COVID-19 vaccination on geriatric hip fracture outcomes. We hypothesise that having the COVID-19 vaccine improves outcomes for geriatric patients treated for hip fracture. Methods: Between December 2020 and January 2022, 506 patients treated for hip fracture were analysed for demographics, hospital quality measures, and outcomes. Patients were grouped according to vaccine series administration status. During the study period, there were 329 (65%) unvaccinated patients (NV), 14 (3%) partially vaccinated (PV) patients, 138 (27%) fully vaccinated (FV) patients, and 25 (5%) patients received a booster shot (BV). Variables were compared using chi square, independent sample t-tests or ANOVA as appropriate. Multivariable logistic regression was used to independently assess the impact of vaccination. Results: The rate of minor complications decreased if any vaccination status was achieved (NV: 37.99%, PV: 21.34%, FV: 28.26%, BV: 20.00%; p = 0.054). Vaccinated patients had a decreased need for Intensive Care Unit (ICU) level care (NV: 14.89%, PV: 7.14%, FV: 5.80%, BV: 8.00%; p  = 0.038). There were no differences in inpatient or 30-day mortality, major complications, length of stay, home discharge, or readmission within 30 or 90 days. Vaccination against COVID-19 was independently protective against the need for ICU level care. Additionally, female gender and vaccination against COVID-19 decreased the rate of minor complications. Older age and higher comorbidity burden increased the rate of minor complications. Discussion: In the hip fracture population, vaccination against COVID-19 was protective against the need for ICU level care and decreased overall minor complications. Larger studies are needed to determine if vaccination decreases mortality in this population. These findings have resource allocation implications including ICU bed availability during pandemics and patient outreach to improve vaccination status.
Placement of a tracheoesophageal prosthesis using intraoperative ultrasound: A novel technique
Authors: Shaver Timothy Brandon , Youner Emily , Joshi Arjun S 
Published: January 2023

Introduction: In patients who undergo a total laryngectomy, one of the most common techniques for voice rehabilitation is a tracheoesophageal prosthesis. Typically, this is accomplished using an endoscope down the oesophagus to visualise puncturing of the posterior tracheal wall; however, we present a case in which the use of an endoscope was not feasible, and a novel technique had to be utilised. Case report: A mid-70s male who had a total laryngectomy secondary to laryngeal carcinoma was undergoing tracheoesophageal puncture for prosthesis placement, when it was noted that he had significant stenosis of his proximal oesophagus, precluding the use of an endoscope. The senior author decided to use intraoperative ultrasound to visualise the oesophageal lumen for proper placement of the puncture. Discussion: This case demonstrates the ability of intraoperative ultrasound to visualise the oesophageal lumen and accurately place the tracheoesophageal puncture in cases where an endoscope cannot be used. Conclusion: We present a novel technique in which ultrasound was used to visualise the oesophageal lumen and identify the needle puncturing the posterior tracheal wall for placement of a tracheoesophageal prosthesis.
Pleiotropy analysis between lobar intracerebral hemorrhage and CSF β-amyloid highlights new and established associations
Authors: Marini Sandro , Chung Jaeyoon , Han Xudong , Sun Xinyu , Parodi Livia , Farrer Lindsay A , Rosand Jonathan , Romero Jose Rafael , Anderson Christopher D 
Published: January 2023

Background and aims: Combining biologically related traits in genome-wide association studies (GWAS) increases the power for genetic discovery. Given the established relationship between lobar intracerebral hemorrhage (ICH) and cerebral amyloid angiopathy (CAA), and between the latter and levels of cerebrospinal fluid amyloid-β 42 (CSF-Aβ42), we leveraged genetic predisposition for lower CSF-Aβ42 levels as a proxy phenotype for CAA to identify new genes associated with lobar ICH. Methods: We used publicly available GWAS data for CSF-Aβ42 levels (n = 3146) and for lobar ICH (n = 2094). First, we evaluated the association between lobar ICH risk and CSF-Aβ42 in lobar ICH patients using a polygenic risk score (PRS) for CSF-Aβ42. Next, we conducted multi-trait analysis of GWAS (MTAG) for pleiotropy analysis of lobar ICH and CSF-Aβ42. MTAG results were further tested using Expression Quantitative Trait Locus and Differential Gene Expression Analyses. Results: CSF-Aβ42 PRS was associated with lobar ICH risk (p = 0.04). MTAG analysis identified a novel association within CDH9 (rs1007589; minor allele frequency = 0.09; MTAG p = 5.4 × 10−8; lobar ICH odds ratio = 1.4 and p = 2.4 × 10−3; CSF-Aβ42 β = −0.03 and p = 4.5 × 10−6). rs1007589 was significantly associated with the expression levels of CDH9 in temporal and occipital cortices, regions known to preferentially accumulate microhemorrhages in CAA. Conclusion: Our pleiotropy analysis suggested a variant possibly implicated with lobar ICH driven by amyloid-related mechanisms in CDH9 and associated with differential expression in brain regions characteristically affected by CAA. CDH9 is one subtype of the cadherin superfamily, which regulates intercellular adhesion, is involved in blood-brain barrier integrity, and is elevated in Alzheimer’s disease patients. Further analyses are warranted to understand the effects of the variant on the pathogenesis of ICH and its clinical significance.