bluuebunny/crossref_metadata_2025_split huggingface dataset:
Does the indication for revision associate with the outcomes of revision total knee arthroplasty? A retrospective analysis with a minimum ten-year follow-up
Authors: Lin Yu-Chih , Chang Chih-Hsiang , Hu Chih-Chien , Chang Yuhan , Lee Sheng-Hsun , Lin Sheng-Hsuan 
Published: January 2023

Abstract
Background
The long-term outcome of revision total knee arthroplasty (rTKA) remains variable. We aimed to determine whether the indication for revision affects rTKA outcomes and assess the risk factors for rTKA failure.
Methods
We reviewed all patients who underwent their first rTKA at our institution between January 2003 and December 2011. Patients were grouped based on the indication for revision. All patients with septic indications underwent staged exchange arthroplasty for periprosthetic joint infection (PJI). Demographic and perioperative variables were compared to analyze the survivorships and the risk factors for treatment failure and implant failure between septic and aseptic indications.
Results
Two-hundred-and-thirty patients (septic indication, 116 patients; aseptic indication, 114 patients) were included. The minimum follow-up duration was 10.3 years (mean: 12.3 years; range: 10.3–19.1 years). The overall treatment success rate of rTKA was 88.3% (203/230). The septic group had a significantly higher failure rate (18.10% vs. 5.26%, p < 0.05) and required earlier re-operation after index revision (14.6 vs. 23.0 months, p < 0.05) than the aseptic group. The identified risk factor in septic group for treatment failure and implant failure is “higher CRP level (> 100 mg/dl) during the first PJI episode before index revision” and “debridement, antibiotics, and implant retention procedure (DAIR) after index rTKA”, respectively. Severe osteoporosis with a history of periprosthetic fracture is the only independent risk factor for implant failure in aseptic group.
Conclusions
One-third of patients with septic indication for rTKA underwent re-operation, mostly for PJI. Identified risk factors for different indications could associate with unfavorable survivorships.
Evaluation of the Validity of Endoscopic Transpapillary Gallbladder Drainage for Acute Cholecystitis Based on the Tokyo Guidelines 2018
Authors: Suzuki Keiichi , Naito Hirofumi , Naito Eri , Sasaki Taketo , Yoshikawa Yusuke , Omagari Kenshi , Yoshitake Naoto , Koike Takero , Hashimoto Takeo , Tamura Akihiko 
Published: January 2023

Abstract
Background The Tokyo Guidelines 2018 recommend early laparoscopic cholecystectomy (Lap-C) for patients with acute cholecystitis (AC). We evaluated the validity of endoscopic transpapillary gallbladder drainage (ETGBD) as a bridging therapy prior to elective Lap-C.
Methods We performed a retrospective cohort analysis using data from our hospital records from 2018 to 2021. In total, 71 ETGBD procedures were performed in 61 patients with AC.
Results The technical success rate was 85.9%. Patients in the failure group had more complicated branching of the cystic duct. The length of time until feeding was started, length of time until the white blood cell count normalized, and length of hospital stay were significantly shorter in the success group. The median waiting period for surgery was 39 days in the ETGBD success group. The median operating time, amount of bleeding, and length of postoperative hospital stay were 134 min, 83.2 g, and 4 days, respectively. In patients who underwent Lap-C, the waiting period for surgery and the operating time were similar between the ETGBD success and failure groups. However, the temporary discharge period after drainage and the length of postoperative hospital stay were significantly longer in the ETGBD failure group. Patients who did not undergo Lap-C tended to have a higher American Society of Anesthesiologists physical status classification and Charlson comorbidity index score.
ConclusionsETGBD has equivalent efficacy prior to elective Lap-C despite some challenges that lower its success rate. Perioperative ETGBD can improve patients’ quality of life by eliminating the need for a drainage tube.
A novel TRP channel-related prognostic model of glioma based on transcriptomics and single cell sequencing analysis
Authors: Niu Xiaochen , Liu Xuanchen , Zhao Xiaohu , Ji Hongming , Wang Chunhong 
Published: January 2023

Abstract
Background
Glioma is the most malignant intracranial tumor. Transient receptor potential (TRP) channel family has been found to be involved in malignant progression of many tumors. However, the relationship between TRP channel-related genes (TCRGs) and glioma remains unclear.
Methods
The TCGA-glioma, CGGA_325, GSE108474 and GSE16011 glioma cohorts were downloaded from the public database. Differential analysis, univariate Cox regression analysis and consistent clustering were performed for 120 TCRGs, and differences in immune microenvironment were analyzed. Lasso Cox regression analysis was used to construct a prognostic model, and the patients were divided into high- and low- risk groups.
Results
Thirty differentially expressed prognostic TCRGs were identified and patients were divided into three subtypes. Lasso Cox regression analysis showed that 10 genes were included in the prognostic model (TRPM6, TRPV3, BDKRB1, HTR2A, P2RY2, PLA2G4D, CAMK2G, MAPK13, ADCY5 and PRKCB). Kaplan-Meier survival analysis showed that patients of the high-risk group had lower survival. Finally, we analyzed five single-cell sequencing data sets (GSE103224, GSE131928, GSE138794, GSE148842 and GSE162631). MAPK13, CAMK2G and PRKCB were significantly expressed in exhausted CD8 + T cells, suggesting that they were closely related to anti-tumor immunity.
Conclusion
Based on the expression of TCRGs, we conducted the new subtype classification and a prognostic model for glioma, and is expected to provide theoretical basis for the development of new targets.
Flint Heat Treatment at Late Neanderthal Site Sesselfelsgrotte (Germany)
Authors: Agam Aviad , Hattermann Merlin , Pinkas Iddo , Richter Jürgen , Uthmeier Thorsten 
Published: January 2023

Abstract
We examine lithic artifacts from Late Neanderthal site Sesselfelsgrotte (Bavaria, Germany) to evaluate the possibility of fire-use and the intentional flint heat treatment performed by Late Neanderthals. We analyzed 1,113 flint pieces from the G-Layers-Complex (~ 60 to 45 kya; Micoquian), and 946 from the Lower-Layers-Complex (~ 115 to 70 kya; Mousterian), based on macroscopic traits associated with the exposure of flint to fire, assigning artifacts to one of three groups: burnt, unburnt, and possibly intentionally heated. Our results show that while both complexes demonstrate clear presence of fire, fire is more common in the younger G-Layers-Complex. Moreover, possibly intentionally heated pieces are significantly more frequent in the G-Layers-Complex, especially among the tools, and specifically among side scrapers, proposing a link between heat treatment and the production of these tools, most probably due to their functional and cultural significance. We therefore suggest the intentional heat treatment of flint in the G-Layers-Complex of Sesselfelsgrotte. The proportions of burnt flint artifacts in both sequences suggest an intensification in fire-use at the site over time, while the appearance of possibly intentionally heated artifacts in the G-Layers-Complex suggests the development of this advanced pyro-technology by Neanderthals, sometime between these two timeframes. Our results are supported by sedimentological and faunal data. We view these results as further indication for the advanced cognitive and technological capabilities of Neanderthals, such that did not fall from these of Early Modern Humans.
Photocatalytic Decomposition of O-ethyl S-[2-diisopropylaminoethyl] methylphosphonothioate, VX, Molecule on Titanium Dioxide in Ambient Condition using ATR-FTIR Spectroscopy
Authors: Hirakawa Tsutomu , Kotb Ayman , Nishimoto Chifumi K. , Komano Asuka , Otsuka Mai , Negishi Nobuaki , Miyaguchi Hajime , Seto Yasuo , Takeuchi Koji 
Published: January 2023

Abstract
The adsorption structure and photocatalytic decomposition of nerve agent, O-ethyl S-[2-diisopropylaminoethyl] methylphosphonothionate (VX) on powdery TiO2 film experimentally studied by using in-situ attenuated total reflection - infrared Fourier transform spectroscopy (ATR-FTIR) at ambient condition. Characteristic IR frequency of VX molecules adsorbed at the surface of TiO2 was observed. The results showed that VX molecule at the surface of TiO2 was immediately oxidized to ethyl methylphosphonic acid (EMPA) and diisopropylaminoethanthiol (DESH) by the P-S cleavage. C-N cleavage by the photocatalysis was also observed simultaneously with appearance of the characteristic IR frequencies as secondary amin species. The oxidation of an aliphatic function group of VX molecule was then accompanied by the decomposition of the skeletal structure as P-S and C-N of VX. Rarely EA2192 production by the TiO2 photocatalysis has experimentally verified by this ATR-FTIR analysis. The plausible adsorption structure and the photocatalytic reaction mechanism of VX at the surface of the TiO2 photocatalyst are also elucidated.
Effect of Mechanical Alloying on Pack Boronizing
Authors: albayrak muhammet gökhan , evin ertan 
Published: January 2023

Abstract
In this study, the effect of mechanical alloying on the growth kinetics of boride layer of boronized DIN St28 steel surface was investigated. The powders containing B + SiC + KBF4 were mechanically alloyed by planetary ball milling devices to 10 and 20 h, respectively. The samples were also boronized by the powder-(SiO2–Na2O) mixture for 1023–1173 K temperature and 3, 6 and 12 h, respectively. At the end of the mechanical alloying process, it was determined that the powder particle sizes were in the nanometer scale. According to the microstructure analysis, a single-layer Fe2B structure was successfully obtained on the samples surfaces. It has been observed that the depth of the Fe2B boride layer, which has achieved high diffusivity by creating many defects in the form of nanometer-sized crystal particles, increased with repeated fracture and cold welding of the powder particles with increasing mechanical alloying times. By calculating the activation energies of the powders, their relations with the mechanically unalloyed samples were compared and empirical formulas that could be used for similar experimental conditions were produced.
Electrochemical behavior of X70 and X80 pipeline steels in a simulated soil environment with and without the presence of chlorides
Authors: Ghosh Rishav , Chinara Manaswini , Godbole Kirtiratan , Mondal K. , Mukherjee Subrata 
Published: January 2023

Abstract
The present work investigates the effect of microstructure, pH as well as the role of aggressive chloride ions on the corrosion behavior of American Petroleum Institute (API) X70 and X80 steel grades. The corrosion behavior was studied using single-run dynamic and cyclic polarization in different solutions followed by microstructural analysis of the corroded samples to determine the mode and extent of corrosion damage. The solutions consist of a near-neutral aqueous sodium chloride solution, mildly alkaline carbonate-bicarbonate solution (pH-8.8), and highly alkaline carbonate-bicarbonate solution (pH-12) with and without the presence of chlorides. Ferrite phase in both the steel was found to dissolve preferentially in the different solutions leading to pitting as a result of microgalvanic coupling with the cementite and/or bainite phase. Interestingly, the corrosion resistance of the X70 grade was found to be greater than X80 at near-neutral as well as low alkaline carbonate-bicarbonate solutions, whereas the X80 performed better in higher pH solutions. Such contrasting corrosion behavior is attributed to the compactness, thickness, and electronic resistance of the passive oxide/hydroxide films formed during polarization in both the steel.
Recursive computed ABC (cABC) analysis as a precise method for reducing machine learning based feature sets to their minimum informative size
Authors: Lötsch Jörn , Ultsch Alfred 
Published: January 2023

Abstract
Background
Selecting the k best features is a common task in machine-learning. Typically, a few variables have high importance, but many have low importance (right skewed distribution). This report proposes a numerically precise method to address this skewed feature importance distribution to reduce a feature set to the informative minimum of items.
Methods
Computed ABC analysis (cABC) is an item categorization method that aims to identify the most important elements by dividing a set of non-negative numerical elements into subsets "A", "B" and "C" such that subset "A" contains the "few important " items based on specific properties of ABC curves defined by their relationship to Lorenz curves. In its recursive form, the cABC analysis can be applied again to subset "A". A generic image data set and three biomedical datasets (lipidomics and two genomics datasets) with a large number of variables were used to perform the experiments.
Results
Experimental results show that recursive cABC analysis limits dimensions of data projection to a minimum where the relevant information is still preserved and directs feature selection in machine learning to the most important class-relevant information including filtering feature sets for nonsense variables. Feature sets were reduced to 10% or less of the original variables and still provided accurate classification in data unused for feature selection.
Conclusions
cABC analysis, in its recursive variant, provides a computational precise defined means of reducing information to a minimum. The minimum is the result of a computation of the number of k most relevant items rather than of a decision to select the k best items from a list. Furthermore, precise criteria for stopping the reduction process are available. The reduction to the most important features can increase human comprehension of the properties of the data set. The cABC method is implemented in the Python package "cABCanalysis" available at https://pypi.org/project/cABCanalysis/.
Oleoylethanolamide facilitates PPARa and TFEB signaling and attenuates Ab pathology in a mouse model of Alzheimer’s disease
Authors: Comerota Michele , Gedam Manasee , Xiong Wen , Jin Feng , Deng Lisheng , Wang Meng , Wang Jin , Zheng Hui 
Published: January 2023

AbstractEmerging evidence implicates impaired microglia function and dysregulation of lipid metabolism in Alzheimer’s disease (AD). Oleoylethanolamide (OEA), an endogenous lipid and PPARα agonist, has been shown to promote longevity inC. elegansthrough regulation of lysosome-to-nucleus signaling and cellular metabolism. Using a stable OEA analog, KDS-5104, we found that OEA-PPARα signaling promotes TFEB lysosomal activity independent of mTORC1 and upregulates cell-surface receptor CD36, leading to enhanced microglial Aβ uptake and clearance. These are associated with the suppression of LPS-induced lipid droplet accumulation and inflammasome activation. Chronic treatment of the 5xFAD mice with KDS-5104 restored dysregulated profiles, reduced reactive gliosis and Aβ pathology and rescued cognitive impairments. Together, our study provides support that augmenting OEA-mediated lipid signaling may offer therapeutic benefit against aging and AD through modulating lipid metabolism and microglia phagocytosis and clearance.
Phacoemulsification with implantation of a trifocal intraocular lens in eyes with asteroid hyalosis and synchysis scintillans
Authors: Ortega-Usobiaga Julio , Bilbao-Calabuig Rafael , González-López Félix , Beltrán-Sanz Jaime , Wang Yong , Llovet-Osuna Fernando , Figueroa Marta S 
Published: January 2023

Abstract
PURPOSE
To compare the visual outcomes in both eyes of patients who undergo phacoemulsification and trifocal intraocular lens (IOL) implantation and have asteroid hyalosis (AH) or synchysis scintillans (SS) in only 1 eye.
METHODS
This retrospective comparative cases series study evaluated uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), uncorrected intermediate visual acuity (UIVA), uncorrected near visual acuity (UNVA), predictability, safety, efficacy, and satisfaction after implantation of the same model of trifocal IOL in both eyes (PhysIOL FineVision Pod-F and Micro-F and Rayner RayOne Trifocal).
RESULTS
A total of 164 eyes from 82 patients (41 females, 50%) met the inclusion criteria. There were no statistically significant differences in sphere, cylinder, spherical equivalent, UDVA, UIVA, and UNVA between the groups. Postoperative CDVA was slightly better in the control group (logMAR 0.03) than in the AH/SS group (logMAR 0.04) (p: 0.014). There were no statistically significant differences in predictability, safety index, and efficacy index between the groups. Overall subjective satisfaction was good (98.2%).
CONCLUSIONS
Visual outcomes and satisfaction are good after implantation of trifocal IOLs in eyes with AH or SS. Therefore, trifocal IOLs should not be ruled out in these patients when no other vitreoretinal disorder is present.
Influence of waste Phaeophyceae filler on green cutting with water jets in jute fibre reinforced polymer biocomposites
Authors: Karthikeyan R , Madhu S , Nixon George Sahaya , Yuvarajan D 
Published: January 2023

Abstract
As reinforcement in polymer composites, natural fibers have been widely used across multiple industries including transportation, aerospace, and medicine. Conventional machining methods produced delamination in polymeric composites. Abrasive water jet machining (AWJ) is a proven technology to machine polymeric composites with finished shapes. In this work jute fiber-reinforced polymer composites are prepared using a hand layup process. A certain percentage of marine algae species naturally produce toxins, which can be harmful to animals that consume them. When algal blooms take place, they can trigger the increase of toxic algae species. Phaeophyceae (brown algae) filler with 0, 3, and 6 wt. % were used as fillers in epoxy resin. Holes were made on the fabricated samples using AWJ. The effect of parameters such as traverse speed, stand-off distance (SOD), and water jet pressure on material removal rate (MRR) and surface roughness (Ra) was investigated. The experimental research shows that the addition of Phaeophyceae powder increased the MRR significantly. Jute fiber-reinforced polymer composites filled with 3 wt.% Phaeophyceae filler improved the MRR up to 12. % And reduced surface roughness up to 8% as compared with other composite samples. Also in this investigation, it was observed that pressure (P) and SOD are the influential parameters that affect the material removal rate and surface roughness significantly in brown algae-filled jute fiber biocomposites.
Hybrid pedicle screw and modified cortical bone trajectory technique in transforaminal lumbar interbody fusion at L4-L5 segment： finite element analysis
Authors: Kahaer Alafate , Zhang Rui , Wang Yixi , Luan Haopeng , Maimaiti Abulikemu , Liu Dongshan , Shi Wenjie , Zhang Tao , Guo Hailong , Rexiti Paerhati 
Published: January 2023

Abstract
Background:: Investigate the biomechanical properties of the hybrid fixation technique with bilateral pedicle screw (BPS) and bilateral modified cortical bone trajectory screw (BMCS) in L4-L5 transforaminal lumbar interbody fusion (TLIF).
Methods: Three finite element (FE) models of the L1-S1 lumbar spine, including seven ligaments and facet joint cartilage were established according to the four human cadaveric lumbar specimens. BPS-BMCS (BPS at L4 and BMCS at L5), BMCS-BPS (BMCS at L4 and BPS at L5), BPS-BPS (BPS at L4 and L5), and BMCS-BMCS (BMCS at L4 and L5) were implanted into the L4-L5 segment of each FE model. The range of motion (ROM) of the L4-L5 segment, the von Mises stress of the fixation, intervertebral cage, and rod were compared under a 400-N compressive load with 7.5 N/m moments in flexion, extension, bending, and rotation.
Results: BPS-BMCS technique has the lowest ROM in extension and rotation, and BMCS-BMCS has the lowest ROM in flexion and lateral bending. The BMCS-BMCS group showed maximal cage stress in flexion and lateral bending, and the BPS-BPS group in extension and rotation. Compared to the BPS-BPS and BMCS-BMCS group, BPS-BMCS presented a lower risk of screw breakage and BMCS-BPS presented a lower risk of rod breakage.
Conclusion: The results of this study support that the use of the BPS-BMCS and BMCS-BPS techniques in TLIF surgery for offering the superior stability and a lower risk of cage subsidence and instrument-related complication.
Stability of solutions to functional KPP-Fisher equations
Authors: Solar Abraham 
Published: January 2023

Abstract
We study the stability properties of semi-wavefronts of the KPPFisher equation with infinite delay ∂/∂t u(t, x) = ∂/∂x2 u(t, x)+∫0+∞ u(t−s, x)dμ1(s)(1 − ∫0+∞ u(t − s, x)dμ2(s)), t > 0, x ∈ R, where μ1 and μ2 are Borel measures. We make an interesting remark about the non convergence in form when the delay is finite, unlike the classic convergence result to KPP-Fisher equation without delay. We also present a result about the stability of semi-wavefronts to the Neutral KPP-Fisher.
Screening the Promising Wild Emmer Wheat Genotypes Containing the Yr-15 Gene in Türkiye and Syria Through Molecular Markers
Authors: TURGAY Emine Burcu Burcu 
Published: January 2023

Abstract
Background Stripe rust also known as yellow rust is a most devastating fungal disease of wheat caused by Puccinia striiformis f. sp. tritici (Pst). The possibility of the breakdown of important stripe rust resistance genes and the threat of the emergence of aggressive new races remains a concern in all wheat-growing areas around the world. The presence of Yr15 resistant gene in the wild emmer wheat (Triticum turgidum ssp. dicoccoides) confers strong broad-spectrum resistance to Pst isolates. The aim of this present study was to investigate at molecular level to confirm the presence or absence of the major resistance gene Yr15in tested samples.
Methods and Results A total of 140 wild emmer wheat genotypes originating from Türkiye and Syria were screened using gene specific molecular markers Y15K1_F2/uhw30_1R. Ten promising wild emmer wheat genotypes Türkiye (Diyarbakır) and Syria (Al Qunayţirah) containing the Yr15 gene were identified.
Conclusion These findings can be beneficial in wheat breeding programs to be conducted for resistance to stripe rust. As well, this study contributes to the evolutionary process studies related to Yr15 gene in wild emmer wheat populations of Fertile Crescent.
An Optimized Neural Network-based Channel Estimation Approach for Noma Using Mimo
Authors: Dev Jenish , D Judson 
Published: January 2023

Abstract
The high demand for wireless communication and limited spectral power causes the conventional orthogonal multiple access approach ineffective for 5G communications. Thus, to specify the spectral inefficiency Multiple-input-multiple-output and non-orthogonal multiple access (MIMO-NOMA) were introduced. Here, MIMO and NOMA are integrated to earn to improve the channel capacity and spectral efficiency. However, the high Bit Error Rate (BER) and computational complexity in NOMA_MIMO due to successive interference cancellation (SIC) reduces the system performance for edge user. Thus, different channel estimation techniques are developed in the past to overcome these issues. But still, they face challenges in complexity and error rate. Hence, a novel hybrid Whale optimization algorithm with a Radial Basis Function Neural Network-based channel estimation method (WOA-RBFNN) was proposed in this article. The developed model estimates the path for data transmission for edge user and tunes the channel parameters till it attains their optimal value. The optimal fitness function in the proposed model offers the finest system performances in terms of Bit Error rate (BER), throughput, etc. Furthermore, the results are estimated and compared with the existing techniques for validation purposes. The comparative analysis proves that the developed model earned better performances than the existing ones especially for edge users.