bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perfectionism in the anesthesiological environment
Authors: Kravets Olha , Yekhalov Vasyl , Stanin Dmytro , Krishtafor Daria , Martynenko Danylo 
Published: July 2023

Abstract
Background. Perfectionism today is understood as an individual's psychological conviction that the ideal can and should be achieved, and the imperfect result of work (physical, intellectual, etc.), in their opinion, has no right to exist.
The purpose of the study: Our goal was to consider this psychological phenomenon in the community of anesthesiology interns in comparison with the indicators of practicing doctors, to investigate its negative and positive features, their prevalence and dynamics.
Materials and methods. An anonymous survey of 92 medical interns and 124 participants of short-term trainings in the specialty "Anesthesiology" was conducted according to the M.M. Smith questionnaire. (2016).
Results. Interns showed an average level of tendency towards perfectionism on all other scales, except for "other-oriented perfectionism" where the level of the indicator was low. Practitioners showed an average level of tendency towards perfectionism on the scales "self-worth contingencies", "concern over mistakes", and "doubts about actions", according to all other indicators, the level of tendency was low. Among medical interns, the distribution on a Big-Three Perfectionism Scale showed that the degree of their attachment to rigid, self-critical, and narcissistic types of perfectionism was at an average level, including general. Practitioners showed an average level of tendency only to the rigid type of perfectionism, as for the self-critical and narcissistic types, the level was low, as well as the general one, which except for the average tendency to rigid perfectionism can be assessed as hypoperfectionism.
Conclusions. 1. Neither interns nor participants in training in the specialty "Anesthesiology" in general are supporters of hyper-perfectionism. 2. Intern doctors showed a rather high tendency to "concern over mistakes", which is explained by the fact that they are not yet specialists, but only learning. This can be assessed as constructive perfectionism. 3. Practitioners are prone to "self-oriented perfectionism", which involves high self-demand. This is explained by the specificity of the work of anesthesiologists (surgeons work in a team, an anesthesiologist - alone), who must first of all rely on themselves, and only then on the help of others. 4. Hypoperfectionism of the self-critical and narcissistic types in anesthesiologists with a certain length of work is associated with psychoprotective deviation of professional behavior, which excludes setting extremely high demands for the results of one's work, since the self-critical type implies a high probability of psycho-emotional burnout syndrome, and the narcissistic type sometimes leads to medical errors.
Symmetrization process and truncated orthogonal polynomials
Authors: Dominici Diego , García-Ardila Juan Carlos , Marcellán Francisco 
Published: July 2023

Abstract

We define the family of truncated Laguerre polynomials Pn(x; z), orthogonal with respect to the linear functional ℓ defined by ⟨ℓ, p⟩ = z 0 p(x)x α e −x dx, α > −1. The connection between Pn(x; z) and the polynomials Sn(x; z) (obtained through the symmetrization process) constitutes a key element in our analysis. As a consequence, several properties of the polynomials Pn(x; z) and Sn(x; z) are studied taking into account the relation between the parameters of the three-term recurrence relations that they satisfy. Asymptotic expansions of these coefficients are given. Discrete Painlevé and Painlevé equations associated with such coefficients appear in a natural way. An electro-static interpretation of the zeros of such polynomials as well as the dynamics of the zeros in terms of the parameter z are given.
MSC Classification: Primary: 42C05; 33C50
Metadichol® a Sirtuin Modulator for Anti-Aging Therapies
Authors: Raghavan P.R. 
Published: July 2023

Abstract

There are seven sirtuin genes in humans that encode seven sirtuin enzymes (SIRT1–7), each of which has unique functions and subcellular locations. Sirtuins are NAD+-dependent protein deacetylases that play a significant role in physiological processes such as energy metabolism, stress responses, DNA repair, and gene expression. Sirtuins are essential targets for aging-related diseases such as type 2 diabetes, inflammatory diseases, and neurodegenerative disorders. However, finding a single molecule that can activate all seven sirtuin genes is challenging because each isoform has a unique structure, substrates, and regulatory mechanisms. Most known sirtuin activators are specific for SIRT1, the most studied isoform of the sirtuin family. Here, we report that Metadichol®, a nano-emulsion of long-chain alcohols, induces 3- to 15-fold expression of all SIRT1–7 genes in human dermal fibroblasts when used in concentrations ranging from 1 pg/mL to 100 ng/mL. SIRT3 and FOXO1 gene expressions were 15-fold higher than those after treatment with Metadichol®. In addition, KL, FOXO1, TERT, and TP53 exhibited increased expression. Sirtuins and the four genes regulate aging, metabolism, and DNA repair and are age-related diseases like cancer, cardiovascular disease, and diabetes. All of these genes play essential roles in improving the quality of life as we age.
Identification of METTL3 as a myeloid-related prognosis biomarker in hepatocellular carcinoma using bioinformatics analysis and engineered mice model
Authors: Wang Qing , Wang He , Yang Changjie , Wang Xiao , Meng Jiaxiang 
Published: July 2023

Abstract
Background
Hepatocellular carcinoma (HCC) is a significant contributor to cancer-related mortality, ranking third in this regard. The epigenetic regulation of RNA N6-methyladenosine (m6A) modification in HCC has garnered considerable attention. This study utilized bioinformatics analysis and biologically engineered mice models to explore the immune and prognostic role of m6A modification in HCC.
Methods
We systematically analyzed genetic alterations, expression patterns, signaling pathways, prognostic features, and immunotherapy efficacy of the 21 m6A regulators in HCC as obtained from the Cancer Genome Atlas (TCGA), the Gene Expression Omnibus (GEO, GSE14520, GSE76427), and International Cancer Genome Consortium (IGCG) database; Unsupervised clustering, gene set variation analysis (GSVA), LASSO-COX regression, multivariate Cox regression, Nomogram, receiver operating characteristic (ROC) analysis, TIMER 2.0 and ImmuCellAI were used to perform the above analysis. Our analysis was verified with Mettl3F/FAlbumin-cre (liver-specific knockout, LKO) mice to establish a chemo-induced HCC model. The tumor immune microenvironment was analyzed with immunohistochemistry, immunofluorescence staining, and flow cytometry.
Results
The genetic alteration of the m6A modification gene set exhibited a correlation with reduced progression-free survival, diminished abundance of macrophage cells, and a lower score for immune cell infiltration. The cluster characterized by lower expression of the m6A gene set was linked to a more favorable overall survival (OS) and immune signaling, including IL2-STAT5, IL6-STAT3, IFN-gamma, and IFN-alpha signaling. Notably, the cluster with higher expression of m6A was associated with a higher homologous recombination deficiency (HRD) score and tumor mutational burden (TMB) score. Results of LASSO COX and the nomogram model underscored the significant contribution of METTL3 in the prognosis and ICB therapy of HCC. The results of Mettl3 LKO mice confirmed that Mettl3 LKO acted as a "rheostat" in the progression of HCC by regulating the mouse liver's myeloid-related innate and adaptive immune landscape.
Conclusions
In this study, we characterized the genetic, immune, and clinic landscape of the m6A gene set in HCC development and unveiled METTL3 as a molecular biomarker in epigenetic-related progress and ICB therapy of HCC from both informatics database analysis and engineered mice model.
Clinical Signature and Associated Immune Metabolism of NLRP1 in Pan-Cancer
Authors: Liao Yong , Yang Pinglian , Wang Jiaojiao , Liu Zhiping , Huang Zunnan 
Published: July 2023

AbstractScattered studies have shown the connection between NLRP1 which is responsible for inflammasome formation and tumor immunity as well as tumor metabolism; however, no research has yet systematically assessed the role and function of NLRP1 on various cancer types. Thus, in this study, data were retrieved and analyzed from public databases, and further showed that NLRP1 was differentially expressed in cancers. High NLRP1 expression was associated with a favorable prognosis for lung adenocarcinoma (LUAD) and pancreatic adenocarcinoma (PAAD). NLRP1 mutation status was also found to be associated with good prognosis. Further, NLRP1 expression was negatively related to tumor stemness, whereas positively related to immune infiltration of tumors. In addition, NLRP1 was found to be significantly related to tumor metabolism. A protein-protein interaction (PPI) network analysis was conducted for NLRP1, as well as pathways and functions of NLRP1. The study aimed to explore the role and function of NLRP1 in tumors by using pan-cancer analysis, and further suggested that NLRP1 may act as a promising therapeutic target for cancer.
Prediction of air quality index using auto machine learning tools over Andhra Pradesh state of India
Authors: Mogaraju Jagadish Kumar 
Published: July 2023

Abstract
Air quality is an essential aspect of any environmental study, and machine learning tools have provided a valuable method to predict the air quality index. In this study, Air Quality Index (AQI) is predicted from significant air quality variables like particulate matter-2.5 (PM 2.5), particulate matter-10 (PM10), NO, NO2, NOx, NH3, CO, SO2, O3, Benzene, Toluene, and xylene using autoML. Fourteen models were compared, and one was selected based on the significant model metrics. Random Forest Classifier is selected as an appropriate model based on model metrics: accuracy, AUC, Recall, Precision, F1 score, Kappa, and MCC. We obtained an accuracy score of 0.97 (97%) with good precision, recall, and F1. Our work supports that fine particulate matter (PM2.5) is crucial in predicting AQI. It is observed that the AutoML tools can be handy in machine learning tasks.
Effects of water-saving irrigation planning on the underground water in the low area of Yellow River, China
Authors: Zhao Qian , Wang Jinhe , Wang Wei , Zhang Taiping , Wang Qiang , Chen Huanliang , Zhang Ruihua , Zhang Hongjun , Xu Yan , Gang Shenting , Li Changsuo , Xu Jingtao , Xu Zhipeng , Shi Yanfeng , Li Jingjing 
Published: July 2023

Abstract

The Yellow River Delta is considered one of the most water-stressed regions in China as the competition for water between various industrial sectors and agriculture is increasing. Since 2007, the regional governments have taken a leading role in agricultural water-saving planning by upgrading irrigation systems and constructing water-saving facilities. In this study, the effects of water-saving irrigation strategies on the groundwater table and quality were investigated in the Yellow River basin during the last two decades. The average phreatic water level of bore-wells was monitored as 13.47 m during 2011–2020 compared to the level of 12.09 m during 2011–2020. Besides, the depth of the deep confined aquifer dropped dramatically during 2001–2013 with a declining rate of 2.55 meters per annum (m/a) compared to the value of 0.385 m/a after 2014, suggesting the reduced exploitation of deep groundwater and increased availability of groundwater after the water-saving campaign. In addition, the physicochemical parameters of both phreatic water and deep confined aquifer indicated improved water quality. Consequently, understanding how the water-saving planning influences the groundwater availability is important, which would provide an insightful guidance for the water managers to protect the groundwater environment in the Yellow River Delta.
Variación fenológica de Rhizophora mangle, Conocarpus erectus y Laguncularia racemosa en Isla Múcura, Parque Nacional Natural Los Corales del Rosario y de San Bernardo, Caribe colombiano
Authors: Henao-Castro Alejandro , Valcárcel Castellanos Camilo , López Paternina Guido Ricardo 
Published: July 2023

Los manglares son ecosistemas marino costeros estratégicos ofrecen una variedad de servicios a la humanidad. No obstante, son vulnerables a perturbaciones naturales y antropogénicas, dentro de las cuales la fragmentación representa una mayor amenaza. Consecuente con lo anterior, han sido identificados como valor objeto de conservación del PNN Los Corales del Rosario y de San Bernardo (PNNCRSB). En particular, las especies más representativas son el mangle rojo Rhizophora mangle, el zaragoza Conocarpus erectus y el amarillo Laguncularia racemosa. Actualmente, la información existente y el programa de monitoreo de esta área protegida se limita a datos de coberturas, por lo que no existe información disponible sobre la fenología de estas especies. Por lo tanto, esta investigación tuvo como objetivo evaluar la variación de eventos fenológicos (producción de frutos, flores y hojas) de mangles rojo, zaragoza y amarillo en el PNNCRSB durante 2014-2015 y su relación con patrones climáticos interanuales. Los resultados muestran que existen patrones temporales de la variación de los eventos fenológicos. En el caso de R. mangle, no evidenció caída de hojas, pero sí presentó frutos y flores durante los 24 meses. Algo similar se observó para C. erectus. También se registraron correlaciones canónicas robustas y significativas (R>6; p<0,05) de grupos de variables ambientales climáticas y los eventos fenológicos en las tres especies en los dos años de estudio. De esta forma se infiere que existen condiciones ambientales idóneas para el desarrollo de los mangles y que los patrones climáticos inciden sobre la fenología de estas especies en el área de estudio. Finalmente, las características fenológicas de las especies se proponen como insumo importante para la adopción de medidas de manejo como procesos de restauración, pues permiten conocer los periodos indicados para realizar actividades de recolecta de propágulos, montaje de viveros y siembra de plántulas en zonas degradadas.
SFXN3 is Associated with Poor Clinical Outcomes and Sensitivity to the
Hypomethylating Therapy in Non-M3 Acute Myeloid Leukemia Patients
Authors: Dong Yuxuan , Jin Fengbo , Wang Jing , Li Qingsheng , Huang Zhenqi , Xia Leiming , Yang Mingzhen 
Published: July 2023

Background:
DNA hypermethylation plays a critical role in the occurrence and progression
of acute myeloid leukemia (AML). The mitochondrial serine transporter, SFXN3, is vital for onecarbon
metabolism and DNA methylation. However, the impact of SFXN3 on the occurrence and progression
of AML has not been reported yet.

Objective:
In this study, we hypothesized that SFXN3 indicates a poor prognosis and suggested tailored
treatment for AML patients.

Methods:
We used GEPIA and TCGA repository data to analyze the expression of SFXN3 and its correlation
with survival in AML patients. RT-qPCR was used to detect the SFXN3 level in our enrolled
AML patients and volunteers. Additionally, Whole Genome Bisulfite Sequencing (WGBS) was used
to detect the genomic methylation level in individuals.

Results:
Through the TCGA and GEPIA databases, we found that SFXN3 was enriched in AML patients,
predicting shorter survival. Furthermore, we confirmed that SFXN3 was primarily overexpressed
in AML patients, especially non-M3 patients, and that high SFXN3 in non-M3 AML patients
was found to be associated with poor outcomes and frequent blast cells. Interestingly, non-M3
AML patients with high SFXN3 levels who received hypomethylating therapy showed a higher CR
ratio. Finally, we found that SFXN3 could promote DNA methylation at transcription start sites (TSS)
in non-M3 AML patients. These sites were found to be clustered in multiple vital cell functions and
frequently accompanied by mutations in DNMT3A and NPM1.

Conclusion:
In conclusion, SXFN3 plays an important role in the progression and hypermethylation
in non-M3 AML patients and could be a potential biomarker for indicating a high CR rate for hypomethylating
therapy.
THE INFLUENCE OF THE PLANT ADAPTOGENE "VICTORIN" ON THE FUNCTIONAL STATE OF THE CARDIOVASCULAR SYSTEM IN PERSONS WITH INCREASED THERMAL SENSITIVITY.
Authors: Гук Вікторія , Вадзюк Степан 
Published: July 2023

Abstract. Introduction. Global warming is the most urgent environmental problem today. It has been established that the optimal functioning of the cardiovascular system is necessary for the survival of the human body in the conditions of climate change. Such means as adaptogens are used to increase the body's resistance to adverse environmental factors.
The aim of the study. To study the influence of the plant adaptogen "Victorin" on the functional state of the cardiovascular system of healthy individuals with increased sensitivity to heat.
Research materials and methods. 14 healthy students aged 17-20 years with increased sensitivity to temperature were selected. All persons were suggested to use 1 capsule of the herbal preparation "Victorin" daily in the first half of the day for 30 days. Assessment of subjective changes in the general state, well-being and functional state of the cardiovascular system using the Robinson index, the index of the response of the cardiovascular system to psycho-emotional stress, the Kerdo index, determination of adaptation potential according to the method of R.M. Baevsky was conducted on the 1st, 15th and 30th days of the study.
Research results. All those examined on the 30th day of the study noted that they feel better heat tolerance, feel more comfortable in conditions of increased ambient temperature. The established tendency to decrease the average value of the Robinson index by 10 n.u. (10.1%), compared to the 1st day of the study. The average value of the index of the response of the cardiovascular system to psycho-emotional stress on the 30th day decreased by 0.147 n.u. (11%) (p<0.01). After a 30-day intake of the plant adaptogen "Victorin", a decrease in the tone of the sympathetic nervous system and its shift towards autonomous balance was revealed. The value of adaptation potential on the 30th day of the study is 9.3% less, compared to the initial indicators (р<0.01).
Conclusions. Taking a plant adaptogen in people with a higher sensitivity to heat caused a tendency to increase the reserve capacity of the cardiovascular system and its more economical activity, contributed to an increase in stress resistance, a decrease in the tone of the sympathetic nervous system, and an increase in the adaptation potential.
FACTORS INFLUENCING HOUSE BUYER’S DECISION IN MALAYSIA. CASE STUDY: SEPANG, SELANGOR
Authors: Zulkifli Fatimah , Ismail Hafiszah 
Published: July 2023

Housing is a basic human need as explained in the Maslow hierarchy needs. Having a house is a very important entity in ensuring a sense of security for each individual and family. Deciding on buying a house is a crucial decision since housing expenses involved a large amount of cost in individual monthly expenses. Furthermore, the homeownership rate in Malaysia as reported by the Department of Statistics Malaysia (DOSM) in 2019 didn’t increase significantly. Thus, the government and house developers need to identify the important factors that influence the house buying decision-making to increase the homeownership rate in Malaysia. This study investigates the factors influencing housing buying decisions and the difference in factors influencing different income groups in Sepang, Selangor. This study measures the internal factors and external factors influencing house-buying decisions. The internal factors measure the income, stage of life cycle, employment and education subfactors. The external factors measure the financial and economic condition, house price, location, neighbourhood, house type and design and also government housing incentives. A mixed method was applied in this study by interviewing real estate experts and also a survey of 184 respondents in the case study area. Using transcribe method and analysing of the survey data with descriptive and inferential analyses to study the influencing factors. The real estate expert and respondents agreed all the factors were influencing house buying decisions except for education. The importance of the factors is also different among the income groups. For internal factors, all income groups agree that income is the most influential factor followed by employment, stage of life cycle and education. The importance of external factors is different among the groups.
Effectiveness of Home-Based Telerehabilitation Interventions for Dysphagia in Patients With Head and Neck Cancer: Systematic Review
Authors: Yang Wenwen , Du Yifei , Chen Mengran , Li Sufang , Zhang Fan , Yu Peiyang , Xu Xiaoxia 
Published: July 2023

Background
Multimodal treatment–induced dysphagia has serious negative effects on survivors of head and neck cancer. Owing to advances in communication technologies, several studies have applied telecommunication-based interventions that incorporate swallowing exercises, education, monitoring, feedback, self-management, and communication. It is especially urgent to implement home-based remote rehabilitation in the context of the COVID-19 pandemic. However, the optimal strategy and effectiveness of remote interventions are unclear.

Objective
This systematic review aimed to examine the evidence regarding the efficacy of telerehabilitation for reducing physiological and functional impairments related to swallowing and for improving adherence and related influencing factors among head and neck cancer survivors.

Methods
The PubMed, MEDLINE, CINAHL, Embase, and Cochrane Library databases were systematically searched up to July 2023 to identify relevant articles. In total, 2 investigators independently extracted the data and assessed the methodological quality of the included studies using the quality assessment tool of the Joanna Briggs Institute.

Results
A total of 1465 articles were initially identified; ultimately, 13 (0.89%) were included in the systematic review. The quality assessment indicated that the included studies were of moderate to good quality. The results showed that home-based telerehabilitation improved the safety of swallowing and oral feeding, nutritional status, and swallowing-related quality of life; reduced negative emotions; improved swallowing rehabilitation adherence; was rated by participants as highly satisfactory and supportive; and was cost-effective. In addition, this review investigated factors that influenced the efficacy of telerehabilitation, which included striking a balance among swallowing training strategy, intensity, frequency, duration, and individual motor ability; treating side effects of radiotherapy; providing access to medical, motivational, and educational information; providing feedback on training; providing communication and support from speech pathologists, families, and other survivors; and addressing technical problems.

Conclusions
Home-based telerehabilitation has shown great potential in reducing the safety risks of swallowing and oral feeding, improving quality of life and adherence, and meeting information needs for dysphagia among survivors of head and neck cancer. However, this review highlights limitations in the current literature, and the current research is in its infancy. In addition, owing to the diversity of patient sociodemographic, medical, physiological and functional swallowing, and behavioral factors, we recommend the development of tailored telemedicine interventions to achieve the best rehabilitation effects with the fewest and most precise interventions.