bluuebunny/crossref_metadata_2025_split huggingface dataset:
Revealing the secrets of a 2900-year-old clay brick, discovering a time capsule of ancient DNA
Authors: Arbøll Troels Pank , Rasmussen Sophie Lund , de Jonge Nadieh , Hansen Anne Haslund , Pertoldi Cino , Nielsen Jeppe Lund 
Published: August 2023

AbstractThe recent development of techniques to sequence ancient DNA has provided valuable insights into the civilisations that came before us. However, the full potential of these methods has yet to be realised. We extracted ancient DNA from a recently exposed fracture surface of a clay brick deriving from the palace of king Ashurnasirpal II (883–859 BCE) in Nimrud, Iraq. We detected 34 unique taxonomic groups of plants. With this research we have made the pioneering discovery that ancient DNA, effectively protected from contamination inside a mass of clay, can successfully be extracted from a 2900-year-old clay brick. We encourage future research into this subject, as the scientific prospects for this approach are substantial, potentially leading to a deeper understanding of ancient and lost civilisations.
Relationship chains of subhealth physical examination indicators: a cross-sectional study using the PLS-SEM approach
Authors: Wang Yu , Lou Jindi , Li Jun , Shi Yulin , Jiang Tao , Tu Liping , Xu Jiatuo 
Published: August 2023

AbstractSubhealth is a transitional state between health and disease, and it can be detected through routine physical check-ups. However, the complexity and diversity of physical examination items and the difficulty of quantifying subhealth manifestations are the main problems that hinder its treatment. The aim of this study was to systematically investigate the physical examination performance of the subhealthy population and further explore the deeper relationships between indicators. Indicators were obtained for 878 subjects, including basic information, Western medicine indicators, inquiries of traditional Chinese medicine and sublingual vein (SV) characteristics. Statistical differences were analysed using R software. To explore the distribution of symptoms and symptom clusters in subhealth, partial least squares-structural equation modelling (PLS-SEM) was applied to the subhealth physical examination index, and a structural model was developed to verify whether the relationship chain between the latent variables was reasonable. Finally, the reliability and validity of the PLS-SE model were assessed. The most common subclinical clinical symptoms were limb soreness (37.6%), fatigue (31.6%), shoulder and neck pain (30.5%) and dry eyes (29.2%). The redness of the SV in the subhealthy group was paler than that in the healthy group (p < 0.001). This study validates the establishment of the directed acyclic relationship chain in the subhealthy group: the path from routine blood tests to lipid metabolism (t = 7.878, p < 0.001), the path from lipid metabolism to obesity (t = 8.410, p < 0.001), the path from obesity to SV characteristics (t = 2.237, p = 0.025), and the path from liver function to SV characteristics (t = 2.215, p = 0.027). The innovative application of PLS-SEM to the study of subhealth has revealed the existence of a chain of relationships between physical examination indicators, which will provide a basis for further exploration of subhealth mechanisms and causal inference. This study has identified the typical symptoms of subhealth, and their early management will help to advance the treatment of diseases.
A novel index for measuring the impact of devices on hypertension
Authors: Kingsmore D. B. , Edgar B. , Rostron M. , Delles C. , Brady A. J. B. 
Published: August 2023

AbstractA key limitation in assessing the therapeutic impact of non-pharmacological approaches to treating hypertension is the method of reporting outcomes. Reducing the medications required to achieve the same blood pressure may be reported separately to a reduction in the blood pressure without change in medication, and thus lessen the reported beneficial impact of treatment. This study aims to derive a novel scoring system to gauge the therapeutic impact of non-drug treatment of hypertension by utilising a combination of excessive blood pressure and the number of anti-hypertensives into a combined score—the hypertensive index (HTi). The hypertensive index was empirically derived based on the systolic blood pressure and number of antihypertensive drugs, and applied retrospectively to a cohort undergoing intervention for renovascular hypertension. Subgroup and receiver operating characteristic analyses were used to compare the HTi to traditional methods of reporting outcomes. Following intervention (99 patients), 46% had improvement in both medication load and blood pressure, 29% had benefit in blood pressure without reduction in medication load, 15% had reduction in medication load without significant change in blood pressure and 9% showed no benefit in either parameter. The HTi was superior in detecting benefit from intervention compared with measuring blood pressure or medication load alone (AUC 0.94 vs 0.85;0.84). The hypertensive index may be a more sensitive marker of treatment effect than assessing blood pressure measurements alone. The use of such scoring systems in future trial design may allow more accurate reporting of the effects of interventions for hypertension.
Prognostic value of post-treatment serum soluble interleukin-2 receptor in newly diagnosed diffuse large B-cell lymphoma patients who achieved complete metabolic response following R-CHOP therapy
Authors: Shirouchi Yuko , Nishimura Noriko , Mishima Yuko , Ishihara Yuko , Asai Hiroaki , Tamba Mikako , Hirano Mitsuhito , Hirano Kei , Teramoto Yukako , Yoshida Kikuaki , Takeuchi Kengo , Terauchi Takashi , Maruyama Dai 
Published: August 2023

AbstractPatients with DLBCL achieving complete metabolic response (CMR) after initial treatment with R-CHOP generally have a favourable prognosis; however, there are no established prognostic biomarkers for relapse in these patients. Soluble interleukin-2 receptor (sIL-2R) levels at diagnosis are prognostic factors in patients with DLBCL. However, the significance of post-treatment sIL-2R levels is unclear. To determine the significance of post-treatment serum sIL-2R levels on subsequent relapse and survival, we retrospectively analysed 485 patients with newly diagnosed DLBCL who received R-CHOP treatment and achieved CMR. The cumulative incidence of relapse (CIR) was significantly higher in patients with elevated post-treatment sIL-2R levels than in those with normal sIL-2R levels (five-year CIR; 38.8% vs. 12.8%). The prognostic value remained significant in multivariable analysis (hazard ratio, 2.30; p < 0.001). Five-year progression-free survival (49.0% vs. 83.5%) and overall survival (61.7% vs. 91.6%) rates were lower in patients with elevated post-treatment sIL-2R levels than in those with normal sIL-2R levels (p < 0.001 for both). In patients with newly diagnosed DLBCL who achieved CMR after R-CHOP treatment, the post-treatment serum sIL-2R level was an independent prognostic marker of subsequent relapse and survival.
On Zagreb coindices and Mostar index of $$TiO_2$$ nanotubes
Authors: Imran Muhammad , Malik Mehar Ali , Aqib Muhammad , Aslam Gul I Hina , Ali Amjad 
Published: August 2023

AbstractTopological indices are valuable tools in predicting properties of chemical compounds. This study focuses on degree-based topological indices, which have shown strong correlations with various physico-chemical properties such as boiling points and strain energy. Specifically, we applied these indices to titania nanotubes $$TiO_2$$

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and explored the vertex and edge versions of the Mostar index. These findings provide insights into the properties of $$TiO_2$$

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nanotubes and contribute to the development of topological indices for predicting the behavior of other chemical compounds.
Factors associated with father–infant bonding during the COVID-19 pandemic: an internet-based cross-sectional study in Japan
Authors: Nishimura Etsuko , Shoki Rina , Kato Mika , Yoneoka Daisuke , Okawa Sumiyo , Tabuchi Takahiro , Ota Erika 
Published: August 2023

AbstractThe COVID-19 pandemic has forced lifestyles changes and affected the relationships between fathers and their infants. However, the factors associated with paternal–infant bonding have not been clarified. This study aimed to explore the factors associated with father–infant bonding during the COVID-19 pandemic in Japan. This cross-sectional study used data from a nationwide survey and the Japanese version of the Mother-to-Infant Bonding Scale (MIBS) to measure father–infant bonding. The participants were divided into two groups depending on their partners’ parity. A linear regression model (Gauss–Markov-type) was used for both groups. A total of 1055 men were included in the analysis. Of these men, 521 (49.4%) had a primipara partner, and 534 (50.6%) had a multipara partner. No significant differences were found between the two groups’ MIBS-J scores. Fathers’ mental health, relationship with the partner and family members, abusive behavior towards children, wanted pregnancy, and the youngest child’s Neonatal Intensive Care Unit admission history were associated with father–infant bonding. Regarding factors related to COVID-19, caring for the child while the partner is at home has a negative impact on bonding, while fear related to infection with COVID-19 has no negative impact on bonding.
The effect of impaired velocity signals on goal-directed eye and hand movements
Authors: de la Malla Cristina , Goettker Alexander 
Published: August 2023

AbstractInformation about position and velocity is essential to predict where moving targets will be in the future, and to accurately move towards them. But how are the two signals combined over time to complete goal-directed movements? We show that when velocity information is impaired due to using second-order motion stimuli, saccades directed towards moving targets land at positions where targets were ~ 100 ms before saccade initiation, but hand movements are accurate. Importantly, the longer latencies of hand movements allow for additional time to process the sensory information available. When increasing the period of time one sees the moving target before making the saccade, saccades become accurate. In line with that, hand movements with short latencies show higher curvature, indicating corrections based on an update of incoming sensory information. These results suggest that movements are controlled by an independent and evolving combination of sensory information about the target’s position and velocity.
Cohort study to evaluate prognostic factors in idiopathic pulmonary fibrosis patients introduced to oxygen therapy
Authors: Kataoka Kensuke , Oda Keishi , Takizawa Hajime , Ogura Takashi , Miyamoto Atsushi , Inoue Yoshikazu , Akagawa Shinobu , Hashimoto Seishu , Kishaba Tomoo , Sakamoto Koji , Hamada Naoki , Kuwano Kazuyoshi , Nakayama Masayuki , Ebina Masahito , Enomoto Noriyuki , Miyazaki Yasunari , Atsumi Kenichiro , Izumi Shinyu , Tanino Yoshinori , Ishii Hiroshi , Ohnishi Hiroshi , Suda Takafumi , Kondoh Yasuhiro 
Published: August 2023

AbstractWhile high-level evidence is lacking, numerous retrospective studies have depicted the value of supplemental oxygen in idiopathic pulmonary fibrosis (IPF) and other interstitial lung diseases, and its use should be encouraged where necessary. The clinical course and survival of patients with IPF who have been introduced to oxygen therapy is still not fully understood. The objective of this study was to clarify overall survival, factors associated with prognosis, and causes of death in IPF patients after the start of oxygen therapy. This is a prospective cohort multicenter study, enrolling patients with IPF who started oxygen therapy at 19 hospitals with expertise in interstitial lung disease. Baseline clinical data at the start of oxygen therapy and 3-year follow-up data including death and cause of death were assessed. Factors associated with prognosis were analyzed using univariable and multivariable analyses. One hundred forty-seven eligible patients, of whom 86 (59%) were prescribed ambulatory oxygen therapy and 61 (41%) were prescribed long-term oxygen therapy, were recruited. Of them, 111 died (76%) during a median follow-up of 479 days. The median survival from the start of oxygen therapy was 537 ± 74 days. In the univariable analysis, low body mass index (BMI), low forced vital capacity (FVC), low diffusion capacity (DLCO), resting hypoxemia, short 6 min-walk distance, and high COPD assessment test (CAT) score were significantly associated with poor prognosis. Multivariable analysis revealed low BMI, low FVC, low DLCO, low minimum SpO2 on 6MWT, and high CAT score were independent factors for poor prognosis. The overall survival of IPF patients after starting oxygen therapy is about 1.5 years. In addition to pulmonary function tests, 6MWT and patient reported outcomes can be used to predict prognosis more accurately.Clinical Trial Registration: UMIN000009322.
Microbial experience through housing in a farmyard-type environment alters intestinal barrier properties in mouse colons
Authors: Arnesen Henriette , Markussen Turhan , Birchenough George , Birkeland Signe , Nyström Elisabeth E. L. , Hansson Gunnar C. , Carlsen Harald , Boysen Preben 
Published: August 2023

AbstractTo close the gap between ultra-hygienic research mouse models and the much more environmentally exposed conditions of humans, we have established a system where laboratory mice are raised under a full set of environmental factors present in a naturalistic, farmyard-type habitat—a process we have called feralization. In previous studies we have shown that feralized (Fer) mice were protected against colorectal cancer when compared to conventionally reared laboratory mice (Lab). However, the protective mechanisms remain to be elucidated. Disruption of the protective intestinal barrier is an acknowledged player in colorectal carcinogenesis, and in the current study we assessed colonic mucosal barrier properties in healthy, feralized C57BL/6JRj male mice. While we found no effect of feralization on mucus layer properties, higher expression of genes encoding the mucus components Fcgbp and Clca1 still suggested mucus enforcement due to feralization. Genes encoding other proteins known to be involved in bacterial defense (Itln1, Ang1, Retnlb) and inflammatory mechanisms (Zbp1, Gsdmc2) were also higher expressed in feralized mice, further suggesting that the Fer mice have an altered intestinal mucosal barrier. These findings demonstrate that microbial experience conferred by housing in a farmyard-type environment alters the intestinal barrier properties in mice possibly leading to a more robust protection against disease. Future studies to unravel regulatory roles of feralization on intestinal barrier should aim to conduct proteomic analyses and in vivo performance of the feralized mice intestinal barrier.
Investigating an abnormal hump phenomenon in top gate a-InGaZnO thin-film transistors due to mobile sodium diffusion
Authors: Park So Hee , Kim Min Young , Kim Hyeong Wook , Oh Changyong , Lee Hyeong Keun , Kim Bo Sung 
Published: August 2023

AbstractTop gate a-InGaZnO (IGZO) thin-film transistors (TFTs) annealed at high temperature show excellent initial current–voltage (I–V) characteristics. However, when they are exposed to positive gate bias for a long time, hump can occur in the subthreshold region. This abnormal hump is accelerated at a higher positive gate voltage and mitigate by a negative gate voltage. While the strength of the hump is irrelevant to a change in channel width, it relies significantly on channel length. This phenomenon might be due to mobile Na ions diffused from a glass substrate migrating toward the back and edge side of the IGZO semiconductor by a vertical gate electric field. When a layer of Al2O3 is formed between the IGZO semiconductor and the glass substrate, the hump phenomenon could be successfully solved by serving as a barrier for Na ions moving into the IGZO.
Evaluating fine changes in visual function of diabetic eyes using spatial-sweep steady-state pattern electroretinography
Authors: Nagai Norihiro , Mushiga Yasuaki , Ozawa Yoko 
Published: August 2023

AbstractThe visual function of diabetic eyes was assessed to evaluate spatial-sweep steady-state pattern electroretinography (swpPERG) as a potential high-sensitivity analysis method. Data from 24 control eyes, 28 diabetic eyes without diabetic retinopathy (DR), and 30 diabetic eyes with DR (all with best-corrected visual acuity [BCVA] better than logMAR 0.05; median age, 51) in response to spatial-patterned and contrast-reversed stimuli of sizes 1 (thickest) to 6 were converted into the frequency domain using a Fourier transform and expressed as signal-to-noise ratios (SNRs). SNRs of diabetic eyes, both with and without DR, were lower than those of controls (P < 0.05), and those of DR eyes were lower than those of diabetic eyes without DR (P < 0.05). The SNRs were correlated with ganglion cell layer volume measured using optical coherence tomography (OCT) and foveal vascular length density at the superficial retinal layer measured using OCT angiography (P < 0.05 or < 0.01, according to stimulus size). Therefore, swpPERG SNRs could detect fine reductions in visual function in diabetic eyes and were particularly low in DR eyes. Moreover, SNRs were correlated with inner retinal morphological changes in diabetic eyes, both with and without DR. swpPERG may therefore be useful for detecting fine fluctuations in visual function in diabetic eyes.
The dynamics of unstable waves in sea ice
Authors: Alberello Alberto , Părău Emilian , Chabchoub Amin 
Published: August 2023

AbstractWave and sea ice properties in the Arctic and Southern Oceans are linked by feedback mechanisms, therefore the understanding of wave propagation in these regions is essential to model this key component of the Earth climate system. The most striking effect of sea ice is the attenuation of waves at a rate proportional to their frequency. The nonlinear Schrödinger equation (NLS), a fundamental model for ocean waves, describes the full growth-decay cycles of unstable modes, also known as modulational instability (MI). Here, a dissipative NLS (d-NLS) with characteristic sea ice attenuation is used to model the evolution of unstable waves. The MI in sea ice is preserved, however, in its phase-shifted form. The frequency-dependent dissipation breaks the symmetry between the dominant left and right sideband. We anticipate that this work may motivate analogous studies and experiments in wave systems subject to frequency-dependent energy attenuation.
The contribution of maternal oral, vaginal, and gut microbiota to the developing offspring gut
Authors: Russell Amber L. , McAdams Zachary L. , Donovan Erin , Seilhamer Nicole , Siegrist Melissa , Franklin Craig L. , Ericsson Aaron C. 
Published: August 2023

AbstractThere is limited understanding of how the microbiota colonizing various maternal tissues contribute to the development of the neonatal gut microbiota (GM). To determine the contribution of various maternal microbiotic sites to the offspring microbiota in the upper and lower gastrointestinal tract (GIT) during early life, litters of mice were sacrificed at 7, 9, 10, 11, 12, 14, and 21 days of age, and fecal and ileal samples were collected. Dams were euthanized alongside their pups, and oral, vaginal, ileal, and fecal samples were collected. This was done in parallel using mice with either a low-richness or high-richness microbiota to assess the consistency of findings across multiple microbial compositions. Samples were analyzed using 16S rRNA amplicon sequencing. The compositional similarity between pup and dam samples were used to determine the contribution of each maternal source to the composition of the neonate fecal and ileal samples at each timepoint. As expected, similarity between neonate and maternal feces increased significantly over time. During earlier time-points however, the offspring fecal and ileal microbiotas were closer in composition to the maternal oral microbiota than other maternal sites. Prominent taxa contributed by the maternal oral microbiota to the neonate GM were supplier-dependent and included Lactobacillus spp., Streptococcus spp., and a member of the Pasteurellaceae family. These findings align with the microbial taxa reported in infant microbiotas, highlighting the translatability of mouse models in this regard, as well as the dynamic nature of the GM during early life.
Evaluation of the efficacy of transient overvoltages suppression measures in different wind farm topologies using SF6 circuit breaker
Authors: Eliyan Tamer , Wadie Fady 
Published: August 2023

AbstractVarious overvoltage mitigation schemes were used in literature in suppression of switching overvoltages in wind farms. However, the evaluation of how the effectiveness of these mitigation techniques would vary with the change of the wind farm topology is still un-explored territory. The main aim of this paper is to study the effectiveness of four mitigation schemes while using SF6 circuit breaker namely; R–L smart choke, R–C snubber circuit, surge capacitor and pre-insertion resistor (PIR) were studied in four different wind farm topologies; radial, single-sided ring, double-sided ring and star topologies. The topologies were based on a real wind farm located in Zaafrana, Egypt. The results showed that R–L choke to be the most effective scheme for all topologies followed by PIR, R–C snubber and surge capacitor schemes respectively. Their percentage of reduction of overvoltage ranged from 62 to 84% for R–L choke, 33–67% for PIR, 8–25% for R–C snubber circuits and 4–15% for surge capacitors. Also, it was shown that the change of the wind farm topology didn’t affect the order of effectiveness of the mitigation schemes such that R–L remained the most effective and surge capacitor the least effective for all topologies.