bluuebunny/crossref_metadata_2025_split huggingface dataset:
Biometric authentication security enhancement under quantum dot light-emitting diode display via fingerprint imaging and temperature sensing
Authors: Jung Hanyung , Sim Soobin , Lee Hyunkoo 
Published: January 2023

AbstractWe improved biometric authentication security using dual recognition based on fingerprint image detection and skin-temperature-change sensing under quantum dot light-emitting diode (QLED) displays. QLEDs are more advantageous than organic light-emitting diodes (OLEDs) in terms of the contrast classification of patterns such as those in fingerprint recognition, owing to their narrow full-width-half-maximum. In this work, scattered, transmitted, and reflected light was captured from the top of the QLED, improving the digital luminance by 25%, as compared with that of OLEDs, because the electroluminescence spectra of the QLED were sustained, whereas those of the OLED were distorted by the generated noise peaks. A QLED with eight apertures sized up to tens of micrometers, mimicking the actual wiring structure of commercialized smartphones, was implemented to detect human fingerprints. The QLED using reduced graphene oxide as the temperature sensor detected temperature changes instantaneously upon finger touch, showing a 2% temperature response based on the human body temperature; however, the temperature change was less than 0.1% for spoof fingerprints printed on paper. Thus, this study successfully enhanced biometric authentication security, through fingerprint recognition based on image sensing using an optical system with micrometer-sized apertures and skin-temperature detection under QLED displays.
The role of resilience in daily experiences of posttraumatic growth, affect, and HIV/AIDS stigma among people living with HIV
Authors: Pięta Małgorzata , Rzeszutek Marcin 
Published: January 2023

AbstractThis study investigated the intraindividual variability in daily posttraumatic growth (PTG) versus posttraumatic depreciation (PTD), positive and negative affect (PA and NA), and HIV/AIDS stigma among people living with HIV (PLWH). In particular, we examined whether this variability derives from participants’ resilience operationalized on a trait level. The participants included 67 PLWH, who completed a baseline questionnaire on resilience, measured with the Brief Resilience Scale. Following this, they completed the shortened versions of the following inventories over five consecutive days: the Posttraumatic Growth and Posttraumatic Depreciation Inventory V Expanded version Inventory, the Positive and Negative Affect Schedule – Expanded Form, and the Berger HIV Stigma Scale. Hierarchical linear modeling (HLM) was utilized to analyze the study results. We observed significant intraindividual variability in PTG, PTD, PA, NA, and perceived HIV/AIDS stigma. Resilience was related to PTG, PTD, PA, and NA but not to stigma. Moreover, higher resilience was associated with higher, stabler PA and lower, stabler NA. Our results highlight the need of further studies on the daily functioning of PLWH. Specifically, while health status is important, it does not appear to be the predominant source of everyday distress for PLWH. Consequently, psychological counselling for PLWH should concentrate more on the life of the person as a whole and not only on coping with HIV infection.
Pathway-guided monitoring of the disease course in bladder cancer with longitudinal urine proteomics
Authors: Carvalho Luís Botelho , Capelo José Luis , Lodeiro Carlos , Dhir Rajiv , Pinheiro Luis Campos , López-Fernández Hugo , Martins Gonçalo , Medeiros Mariana , Díaz Fernando , Santos Hugo Miguel 
Published: January 2023

Abstract
Background
Monitoring bladder cancer over time requires invasive and costly procedures. Less invasive approaches are required using readily available biological samples such as urine. In this study, we demonstrate a method for longitudinal analysis of the urine proteome to monitor the disease course in patients with bladder cancer.

Methods
We compared the urine proteomes of patients who experienced recurrence and/or progression (n = 13) with those who did not (n = 17). We identified differentially expressed proteins within various pathways related to the hallmarks of cancer. The variation of such pathways during the disease course was determined using our differential personal pathway index (dPPi) calculation, which could indicate disease progression and the need for medical intervention.

Results
Seven hallmark pathways are used to develop the dPPi. We demonstrate that we can successfully longitudinally monitor the disease course in bladder cancer patients through a combination of urine proteomic analysis and the dPPi calculation, over a period of 62 months.

Conclusions
Using the information contained in the patient’s urinary proteome, the dPPi reflects the individual’s course of bladder cancer, and helps to optimise the use of more invasive procedures such as cystoscopy.
Experimental and computational investigation of heteroatom substitution in nucleolytic Cu(ii) cyclen complexes for balancing stability and redox activity
Authors: Hormann Jan , Verbitsky Olga , Zhou Xiaoyu , Battistella Beatrice , van der Meer Margarete , Sarkar Biprajit , Zhao Cunyuan , Kulak Nora 
Published: January 2023

Cu(ii) complexes of heteroatom-substituted cyclen-based ligands were optmizied regarding their redox activity and DNA cleavage activity. The ideal ligand exhibited a balanced set of hard and soft donors (CuL6 with N, O and S donor atoms).
Exploring the mechanism of Cassiae semen in regulating lipid metabolism through network pharmacology and experimental validation
Authors: Huang Lili , Zhu Haiyan , Tang Yuqin , Luo Zheng , Xia Luyun , Zhang Chunjiang , Wang Yanqiu , Huai Wenying , Fang Zhiyan , Li Shenrong , Yan Zhiyong , Yin Qiaozhi , Zhang Tian-e 
Published: January 2023

Abstract
Background: Multiple studies have assessed the role of Cassiae semen (CS) in regulating lipid metabolism. However, the mechanism of action of CS on non-alcoholic fatty liver disease (NAFLD) has seen rare scrutiny. Objective: The objective of this study was to explore the regulatory mechanism of CS on lipid metabolism in NAFLD. Methods: Components of CS ethanol extract (CSEE) were analyzed and identified using UPLC-Q-Orbirap HRMS. The candidate compounds of CS and its relative targets were extracted from the Traditional Chinese Medicine Systems Pharmacology, Swiss-Target-Prediction, and TargetNet web server. The Therapeutic Target Database, Genecards, Online Mendelian Inheritance in Man, and DisGeNET were searched for NAFLD targets. Binding affinity between potential core components and key targets was established employing molecular docking simulations. After that, free fatty acid (FFA)-induced HepG2 cells were used to further validate part of the network pharmacology results. Results: Six genes, including Caspase 3 (CASP3), phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit α (PIK3CA), epidermal growth factor receptor (EGFR), and amyloid β (A4) precursor protein (APP) were identified as key targets. The mitogen-activated protein kinase (MAPK) signaling pathway was found to associate closely with CS’s effect on NAFLD. Per molecular docking findings, toralactone and quinizarin formed the most stable combinations with hub genes. About 0.1 (vs. FFA, P&lt;0.01) and 0.2 (vs. FFA, P&lt;0.05) mg/ml CSEE decreased lipid accumulation in vitro by reversing the up-regulation of CASP3, EGFR, and APP and the down-regulation of PIK3CA. Conclusion: CSEE can significantly reduce intracellular lipid accumulation by modulating the MAPK signaling pathway to decrease CASP3 and EGFR expression.
Targeted bisulfite resequencing of differentially methylated cytosines in pre-eclampsia reveals a skewed dynamic balance in the DNA methylation of enhancers
Authors: Zheng Xiaoguo , Wu Weibin , Zhou Qian , Lian Yahan , Xiang Yuqian , Zhao Xinzhi 
Published: January 2023

Abstract
Pre-eclampsia (PE) is a major hypertensive disorder of pregnancy. Widespread differentially methylated cytosines (DMCs) with modest changes in methylation level are associated with PE, whereas their cause and biological significance remain unknown. We aimed to clarify DNA methylation patterns around DMCs in 103 placentas using MethylCap targeted bisulfite re-sequencing (MethylCap-seq) assays of 690 selected DMCs. We verified the MethylCap-seq method, then validated 677 (98.1%) of DMCs (vDMCs) in an independent cohort. The validated DMCs were strongly enriched in active placenta-specific enhancers and showed highly dynamic methylation levels. We found high epigenetic heterogeneity between vDMCs and adjacent CpG sites (r2 &lt; 0.2) and a significant decrease in PE in the discovery and replication cohorts (P = 2.00 × 10−24 and 6.43 × 10−9, respectively). We replicated the methylation changes in a hypoxia/reoxygenation cell model. We constructed 112 methylation haplotype blocks and found that the frequencies of unmethylated haplotypes (UMHs) were dynamic with gestational age (GA) and were altered in maternal plasma of patients with PE. Our results uncovered additional DNA methylation features in PE placentas and suggested a model of skewed DNA methylation balance of enhancers in PE.
Astroglial CB1 receptors, energy metabolism, and gliotransmission: an integrated signaling system?
Authors: Fernández-Moncada Ignacio , Marsicano Giovanni 
Published: January 2023

Abstract
Astrocytes are key players in brain homeostasis and function. During the last years, several studies have cemented this notion by showing that these cells respond to neuronal signals and, via the release of molecules that modulate and support synaptic activity (gliotransmission) participates in the functions of the so-called tripartite synapse. Thus, besides their established control of brain metabolism, astrocytes can also actively control synaptic activity and behavior. Among the signaling pathways that shape the functions of astrocyte, the cannabinoid type-1 (CB1) receptor is emerging as a critical player in the control of both gliotransmission and the metabolic cooperation between astrocytes and neurons. In the present short review, we describe known and newly discovered properties of the astroglial CB1 receptors and their role in modulating brain function and behavior. Based on this evidence, we finally discuss how the functions and mode of actions of astrocyte CB1 receptors might represent a clear example of the inextricable relationship between energy metabolism and gliotransmission. These tight interactions will need to be taken into account for future research in astrocyte functions and call for a reinforcement of the theoretical and experimental bridges between studies on metabolic and synaptic functions of astrocytes.
Self-Perception of Cognitive-Communication Functions After Mild Traumatic Brain Injury
Authors: Norman Rocio , Flaugher Tara , Chang Sharon , Power Emma 
Published: January 2023

Purpose:
A mixed-method approach was used to investigate the lived experiences of adults with mild traumatic brain injury (mTBI). The study aimed to understand the perceived relationship between cognitive-communication problems, thinking and communication concerns, and neurobehavioral symptoms. We hypothesized that individuals with cognitive-communication problems would attribute their problems with communication to their mTBI history and their self-perceived problems would be correlated with symptomatology.

Method:
The Neurobehavioral Symptom Inventory (NSI) and an online cognitive-communication survey was used to conduct a study of 30 adults with mTBI history. Quantitative survey and NSI scores were analyzed with content analysis and correlational statistics.

Results:

The average NSI Total score was 17 with the following subscale scores: somatic (5), affective (8), and cognitive (3.9). Participants reported problems with expressive communication (56%), comprehension (80%), thinking (63%), and social skills (60%). Content analysis revealed problems in the following areas: expression (e.g., verbal, and written language), comprehension (reading and verbal comprehension), cognition (e.g., attention, memory and speed of processing, error regulation), and functional consequences (e.g., academic work, social problems, and anxiety and stress). A Pearson correlation indicated a statistically significant relationship (
p
< .01) between the Communication Survey Total and the Total, Somatic, Affective, and Cognitive subscales.

Conclusions:
This study highlights a multifactorial basis of cognitive-communication impairment in adults with mTBI. We show that those with mTBI history perceive difficulties with cognitive-communication skills: conversations, writing, and short-term memory/attention. Furthermore, those with mTBI perceive their cognitive-communication problems after injury have impacted their vocational, social, and academic success.
An X/Ku band phase shifter with filter compensation technology
Authors: Zeng Jialong , Yu Zhongjun , Yuan Yang , Li Jiaxuan , Zhang Desheng 
Published: January 2023

AbstractThis letter proposes an ultra‐wideband switched T‐type phase shifter, which covers the whole X/Ku band. The proposed switched T‐type phase shifter integrates a switched filter compensation structure, achieving a flat relative phase shift in broadband, which the conventional one cannot acquire. In addition, the designed T‐type phase shifter can further reduce the phase error and improve the phase shift capability with a phase shift greater than 45°. Employing the proposed architecture, a 90° T‐type phase shifter is designed and fabricated in 0.15‐μm GaAs pHEMT process. The measured results show that the proposed T‐type phase shifter achieves a stable 90° phase shift at 8 to 18 GHz with a phase error of less than ±2°, and an insertion loss (IL) of 2.4 to 4.2 dB. And the chip size of the switched T‐type phase shifter is 0.62 × 0.75 mm2. Thanks to its good performance, the proposed T‐type phase shifter is very suitable for various radar and satellite communication systems.
A severely range ambiguous clutter suppression method based on multi‐domain cascaded signal processing for space‐based early warning radar
Authors: Zhang Tianfu , Wang Zhihao , Xing Mengdao , Zhang Shuangxi , Wang Yongliang 
Published: January 2023

AbstractThe non‐stationary clutter phenomenon and the severe range ambiguity make space‐based early warning radar as an intricate model of received ground and sea clutter. The received clutter is severely broadened in Doppler dimension, and the degrees of freedom (DOFs) of the received clutter is severely increased. Because the DOFs of the system is always lower than the theoretical DOFs of the received clutter, the adaptive processing capability of the system is insufficient and the performance of clutter suppression is seriously degraded. A multi‐domain cascaded adaptive processing method is proposed in this study. The proposed method takes full advantage of the digital antenna array to suppress a portion of the clutter energy by introducing the transmit pulse coding domain, and the remaining influential clutter energy is suppressed by introducing the elevation‐dimensional receive channel domain. Finally, the clutter after the two‐dimensional (2D) pre‐processed is suppressed by the 2D adaptive processing in the azimuthal receive beam‐receive Doppler domain. This method pre‐processes the clutter data by extending the processing dimension to meet the freedom requirements of the adaptive signal processing, and the capability of clutter suppression is significantly improved. Simulation examples show the effectiveness of the proposed method.
Combining HIPPARCOS and Gaia data for the study of binaries: The BINARYS tool
Authors: Leclerc A. , Babusiaux C. , Arenou F. , van Leeuwen F. , Bonnefoy M. , Delfosse X. , Forveille T. , Le Bouquin J.-B. , Rodet L. 
Published: January 2023

Context. Orbital motion in binary and planetary systems is the main source of precise stellar and planetary mass measurements, and the joint analysis of data obtained using multiple observational methods can both lift degeneracies and improve precision.
Aims. We set out to measure the masses of individual stars in binary systems using all the information brought by the HIPPARCOS and Gaia absolute astrometric missions.
Methods. We present BINARYS, a tool that uses the HIPPARCOS and Gaia absolute astrometric data and combines them with relative astrometry and/or radial velocity measurements to determine the orbit of a binary system. This tool rigorously combines the HIPPARCOS and Gaia data (here EDR3) and can use the HIPPARCOS Transit Data as needed for binaries where HIPPARCOS detects significant flux from the secondary component. It also supports the case where Gaia has resolved the system, giving an astrometric solution for both components.
Results. We determine model-independent individual masses for the first time for three systems: the two mature binaries Gl 494 (M1 = 0.584 ± 0.003 M⊙ and M2 = 87 ± 1 MJup) and HIP 88745 (M1 = 0.96 ± 0.02 M⊙ and 0.62-0.008+0.009 ), and the younger AB Dor member GJ 2060 (1926-6+7 and 0.882 -0.005+0.004). The latter provides a rare test of evolutionary model predictions at young ages in the low-stellar-mass range and sets a lower age limit of 100 Myr for the moving group.
The nebula around the binary post-AGB star 89 Herculis
Authors: Gallardo Cava I. , Alcolea J. , Bujarrabal V. , Gómez-Garrido M. , Castro-Carrizo A. 
Published: January 2023

Context. There is a class of binary post-asymptotic giant branch (post-AGB) stars that exhibit remarkable near-infrared (NIR) excess. These stars are surrounded by disks with Keplerian or quasi-Keplerian dynamics and outflows composed of gas escaping from the rotating disk. Depending on the dominance of these components, there are two subclasses of binary post-AGB stars: disk-dominated and outflow-dominated.
Aims. We aim to properly study the hourglass-like structure that surrounds the Keplerian disk around 89 Her.
Methods. We present total-power on-the-fly maps of 12CO and 13CO J = 2 − 1 emission lines in 89 Her. Previous studies are known to suffer from flux losses in the most extended components. We merge these total-power maps with previous NOEMA maps. The resulting combined maps are expected to detect the whole nebula extent of the source.
Results. Our new combined maps contain the entirety of the detectable flux of the source and at the same time are of high spatial resolution thanks to the interferometric observations. We find that the hourglass-like extended outflow around the rotating disk is larger and more massive than suggested by previous works. The total nebular mass of this very extended nebula is 1.8 × 10−2 M⊙, of which ∼65% comes from the outflow. The observational data and model results lead us to classify the envelope around 89 Her as an outflow-dominated nebula, together with R Sct and IRAS 19125+0343 (and very probably AI CMi, IRAS 20056+1834, and IRAS 18123+0511). The updated statistics on the masses of the two post-AGB main components reveal that there are two distinct subclasses of nebulae around binary post-AGB stars depending on which component is the dominant one. We speculate that the absence of an intermediate subclass of sources is due to the different initial conditions of the stellar system and not because both subclasses are in different stages of the post-AGB evolution.
Modelling shock-like injections of solar energetic particles with 3D test particle simulations
Authors: Hutchinson A. , Dalla S. , Laitinen T. , Waterfall C. O. G. 
Published: January 2023

Context. Solar energetic particle (SEP) acceleration and injection into interplanetary space during gradual SEP events is thought to take place at coronal mass ejection (CME)-driven shocks. Various features of measured intensity profiles at 1 au have been attributed to properties of the radial, longitudinal, and latitudinal SEP injections at the shock. Focussed transport models are typically used to model acceleration at a CME-shock and subsequent propagation. Test particle simulations are an alternative approach but so far they have been carried out only with instantaneous injection near the Sun.
Aims. We develop the first temporally extended shock-like injection for our 3D test particle code and investigate how the spatial features of injection at a shock affect SEP intensity and anisotropy profiles for observers at 0.3 and 1.0 au.
Methods. We conducted simulations of a monoenergetic population of 5 MeV protons considering three different radial injection functions and two longitudinal and latitudinal injection functions. We considered a range of scattering conditions with scattering mean free path values ranging from λ = 0.1 − 1.0 au, and determined intensity and anisotropy profiles at six observers at different longitudinal locations.
Results. We find that the radial, longitudinal, and latitudinal injection functions play a relatively minor role in shaping the SEP intensity profiles. The dependence of intensity profiles on the value of the scattering mean free path is also weak, unlike what is found from 1D focussed transport models. Spatial factors, such as the times of observer-shock connection and disconnection as well as the time of shock passage have a much stronger influence on SEP intensities and anisotropies. Persistent anisotropies, until shock passage, are seen in our simulations. Comparing instantaneous and shock-like injections, we find that the link between the duration of injection and the duration of the SEP event is very weak, unlike what is commonly assumed.
COVID-19 Vaccines—All You Want to Know
Authors: Shishido Akira A. , Barnes Ashley H. , Narayanan Shivakumar , Chua Joel V. 
Published: January 2023

AbstractThe severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) pandemic has led to an unprecedented public health crisis. The collective global response has led to production of multiple safe and effective vaccines utilizing novel platforms to combat the virus that have propelled the field of vaccinology forward. Significant challenges to universal vaccine effectiveness remain, including immune evasion by SARS-CoV-2 variants, waning of immune response, inadequate knowledge of correlates of protection, and dosing in special populations. This review serves as a detailed evaluation of the development of the current SARS-CoV-2 vaccines, their effectiveness, and challenges to their deployment as a preventive tool.
Update on Sepsis Epidemiology in the Era of COVID-19
Authors: Shappell Claire , Rhee Chanu , Klompas Michael 
Published: January 2023

AbstractTimely and accurate data on the epidemiology of sepsis is essential to inform public policy, clinical practice, and research priorities. Recent studies have illuminated several ongoing questions about sepsis epidemiology, including the incidence and outcomes of sepsis in non-Western countries and in specialized populations such as surgical patients, patients with cancer, and the elderly. There have also been new insights into the limitations of current surveillance methods using administrative data and increasing experience tracking sepsis incidence and outcomes using “big data” approaches that take advantage of detailed electronic health record data. The COVID-19 pandemic, however, has fundamentally changed the landscape of sepsis epidemiology. It has increased sepsis rates, helped highlight ongoing controversies about how to define sepsis, and intensified debate about the possible unintended consequences of overly rigid sepsis care bundles. Despite these controversies, there is a growing consensus that severe COVID-19 causing organ dysfunction is appropriate to label as sepsis, even though it is treated very differently from bacterial sepsis, and that surveillance strategies need to be modified to reliably identify these cases to fully capture and delineate the current burden of sepsis. This review will summarize recent insights into the epidemiology of sepsis and highlight several urgent questions and priorities catalyzed by COVID-19.