bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reconsidering the failure model: Using a genetically controlled design to assess the spread of problems from reactive aggression to internalizing symptoms through peer rejection across the primary school years
Authors: Faur Sharon , Valdes Olivia , Vitaro Frank , Brendgen Mara , Boivin Michel , Laursen Brett 
Published: August 2023

AbstractAccording to the failure model (Patterson & Capaldi, 1990), peer rejection is the intermediary link between problem behaviors and internalizing symptoms. The present study tested the model with 464 monozygotic and same‐sex dizygotic twin pairs (234 female, 230 male dyads). Teacher‐reported reactive aggression and internalizing symptoms, and peer‐reported peer rejection were collected at ages 6, 7, and 10 (from 2001 to 2008). Support for the failure model emerged in conventional non‐genetically controlled analyses, but not twin‐difference score analyses (which remove shared environmental and genetic contributions). Univariate biometric models attributed minimal variance in failure model variables to shared environmental factors, suggesting that genetic factors play an important unacknowledged role in developmental pathways historically ascribed to nonshared experiences in the failure model.
A Characterization of Interactive Visual Data Stories With a Spatio‐Temporal Context
Authors: Mayer Benedikt , Steinhauer Nastasja , Preim Bernhard , Meuschke Monique 
Published: August 2023

AbstractLarge‐scale issues with a spatial and temporal context such as the COVID‐19 pandemic, the war against Ukraine, and climate change have given visual storytelling with data a lot of attention in online journalism, confirming its high effectiveness and relevance for conveying stories. Thus, new ways have emerged that expand the space of visual storytelling techniques. However, interactive visual data stories with a spatio‐temporal context have not been extensively studied yet. Particularly quantitative information about the used layout and media, the visual storytelling techniques, and the visual encoding of space‐time is relevant to get a deeper understanding of how such stories are commonly built to convey complex information in a comprehensible way. Covering these three aspects, we propose a design space derived by merging and adjusting existing approaches, which we used to categorize 130 collected web‐based visual data stories with a spatio‐temporal context from between 2018 and 2022. An analyzis of the collected data reveals the power of large‐scale issues to shape the landscape of storytelling techniques and a trend towards a simplified consumability of stories. Taken together, our findings can serve story authors as inspiration regarding which storytelling techniques to include in their own spatio‐temporal data stories.
Smooth Transitions Between Parallel Coordinates and Scatter Plots via Polycurve Star Plots
Authors: Kiesel Dora , Riehmann Patrick , Froehlich Bernd 
Published: August 2023

AbstractThis paper presents new techniques for seamlessly transitioning between parallel coordinate plots, star plots, and scatter plots. The star plot serves as a mediator visualization between parallel coordinate plots and scatter plots since it uses lines to represent data items as parallel coordinates do and can arrange axes orthogonally as used for scatter plots. The design of the transitions also motivated a new variant of the star plot, the polycurve star plot, that uses curved lines instead of straight ones and has advantages both in terms of space utilization and the detection of clusters. Furthermore, we developed a geometrically motivated method to embed scatter points from a scatter plot into star plots and parallel coordinate plots to track the transition of structural information such as clusters and correlations between the different plot types. The integration of our techniques into an interactive analysis tool for exploring multivariate data demonstrates the advantages and utility of our approach over a multi‐view approach for scatter plots and parallel coordinate plots, which we confirmed in a user study and concrete usage scenarios.
Long‐term impact of gastropexy on use of acid‐reducing medication, second operations for gastroesophageal reflux and subjective reflux symptoms after sleeve gastrectomy
Authors: Flølo Tone Nygaard , Fosså Alexander , Nedkvitne Jonas Ingolf Petersson , Waage Jo Erling Riise , Rekdal Magne , Dankel Simon Nitter , Fernø Johan , Mellgren Gunnar , Nedrebø Bjørn Gunnar 
Published: August 2023

SummaryWe investigated whether adding gastropexy to sleeve gastrectomy (SG) reduced gastroesophageal reflux disease (GERD) in patients operated for severe obesity, assessed mainly by use of anti‐reflux medication (ARM) and second operations due to GERD worsening. In a prospective non‐randomized study, patients undergoing SG at two Norwegian hospitals were included from 2011 to 2015 and followed for 7 years. GERD was defined by regular use of ARM, and epigastric pain and heartburn were measured by the Rome II questionnaire. Gastropexy was done by suturing the gastrocolic ligament to the staple line. Patients undergoing SG only, mainly before gastropexia was introduced in 2013, were compared to those with additional gastropexy from 2013 onwards. Of 376 included patients (75% females, mean age 42.6 years and BMI 42.9 kg/m2), 350 (93%) and 232 (62%) were available for evaluation after 1 and 7 years, respectively. Baseline characteristics in the no‐gastropexy (n = 235) and gastropexy groups (n = 141) were similar. In patients without ARM use before surgery, the use increased and in those that used ARM at baseline, the proportion decreased, with no difference in the no‐gastropexy and gastropexy groups. With a combined endpoint of ARM use and/or second operation for GERD, there was no difference during follow‐up between the two groups. With time, adding gastropexy did not reduce symptoms of GERD significantly. In this population, adding gastropexy to SG did not reduce use of ARM and/or second operation for uncontrolled GERD, epigastric pain or heartburn during the first 7 postoperative years.
Rethinking, reducing, and refining the classical oral tyramine challenge test of monoamine oxidase (MAO) inhibitors
Authors: van Hoogdalem Ewoud‐Jan , Smith Karen L. , Hartstra Jan , Constant John 
Published: August 2023

AbstractThe oral tyramine challenge evaluates the safety of novel monoamine oxidase (MAO) inhibitors when taken with tyramine‐containing food or drinks. In its current design, it comprises an extensive series of tyramine escalation steps until a blood pressure threshold is met. Due to the high variation in tyramine bioavailability, and thereby in blood pressure effect, this classical design has various limitations, including safety concerns. Based on data from a previously performed tyramine challenge study, the present study explored a reduced new design that escalates up to 400 mg, and evaluates the dose to a tyramine peak plasma concentration of ≥10 ng/mL, instead of a dose up to 800 mg, and to a blood pressure change of ≥30 mm Hg. Tested by trial simulation, the new design proves more efficient than the classical design in terms of better identifying tyramine sensitivity of test and reference treatments and reducing false‐positive and false‐negative rates in estimating tyramine sensitivity by more than 10‐fold. Since it escalates over a lower tyramine dose range, the new design reduces risk to subjects associated with tyramine‐induced blood pressure excursions, is less demanding for study participants, and is more efficient. By its focus on tyramine bioavailability as the primary concern for novel MAO inhibitors, the new tyramine challenge study provides better answers in a simplified and safer design compared with the classical design in trial simulation, warranting its use in future clinical studies.
RB1 loss in the mesenchymal component of onychomatricoma
Authors: Liu Yu , Zou Daopei , Huang Qiong , Wang Lei 
Published: August 2023

AbstractBackgroundOnychomatricoma is a nail neoplasm that usually presents as longitudinal nail plate thickening, involving either the partial or whole nail. Histopathologically, it is characterized by deep invaginations of the proliferating nail matrix and proliferation of CD34+ and CD10+ spindle cells with collagenous to myxoid stroma. Onychomatricoma has been considered a fibroepithelial neoplasm. Recently, RB1 loss has been verified using array comparative genomic hybridization.MethodsThis study investigated the RB1 status in onychomatricoma with morphological methods.ResultsSix patients with onychomatricoma were included in the study. RB1 status was assessed using immunohistochemical staining and fluorescence in situ hybridization. Immunohistochemical staining showed that all six cases experienced RB1 loss in the mesenchymal component of onychomatricoma but not in the proliferated nail matrix. Fluorescence in situ hybridization in five cases showed a monoallelic deletion of the RB1 locus in the mesenchymal component but not in the proliferated nail matrix.ConclusionsRB1 loss was observed only in the mesenchymal component of onychomatricoma. Our findings suggest that the proliferated nail matrix in onychomatricoma represents reactive hyperplasia of various degrees secondary to neoplastic mesenchymal proliferation. This indicates that onychomatricoma should be recognized as an RB1‐deleted soft tissue neoplasm rather than a fibroepithelial neoplasm.
Establishment of a new method to isolate viable x‐ray‐sensitive cells from planarian by fluorescence‐activated cell sorting
Authors: Ishida Miyuki , Kuroki Yoshihito , Agata Kiyokazu 
Published: August 2023

AbstractPlanarians show outstanding regenerative ability due to the proliferation of neoblasts. Hence the method to isolate planarian neoblasts is important to understand the regeneration process. In our previous study, we reported a method to isolate planarian neoblasts of Dugesia japonica using fluorescence‐activated cell sorting (FACS). However, we have not yet succeeded in cultivating these cells even under in vivo conditions after transplantation into x‐ray‐irradiated planarians. This suggests that dissociated cells might enter apoptotic or necrotic states in the process of fluorescent dye staining and sorting. Here, we developed a new method to isolate viable neoblasts, which can proliferate in the x‐ray‐irradiated planarians. First, the toxicity of various fluorescence dyes was investigated. All nuclear fluorescent dyes such as Hoechst 33342, DRAQ5, and DyeCycle, showed, more or less, toxicity to mammalian culture cells. In contrast, cytoplasmic fluorescent dye for live cells, calcein AM, was less toxic on these cells. Next, we stained the dissociated planarian cells with only calcein AM, and then collected the x‐ray‐sensitive fraction. Although the purity of neoblasts was slightly lower than that of the original staining method (ca. 97% → ca. 89%), the sorted cells could actively proliferate when they were injected into x‐ray‐irradiated planarians. This simple staining and sorting method will provide new opportunities to isolate viable neoblasts and understand regenerating processes.
Causes of death among Australians with type 1 or type 2 diabetes, 2002–2019
Authors: Tomic Dunya , Chen Lei , Moran Lauren L. , Magliano Dianna J. , Shaw Jonathan E. 
Published: August 2023

AbstractAimsThis population‐based study sought to explore in detail the conditions driving the diversification in causes of death among people with diabetes.MethodsWe linked Australians with type 1 or type 2 diabetes of all ages on the National Diabetes Services Scheme to the National Death Index for 2002–2019. We investigated the proportional contributions of different causes of death to total deaths over time across eight categories of causes of death, stratified by sex and diabetes type. The underlying causes of death were classified according to the International Classification of Diseases, Tenth Revision codes.ResultsBetween 2002 and 2019, there was a shift in the causes of death among Australians with diabetes away from cardiovascular disease. The proportion of deaths attributed to cardiovascular disease declined in both sexes (ptrend <0.001), most substantially among women with type 2 diabetes from 48.2% in 2002 to 30.7% in 2019. Among men with type 2 diabetes, cancer replaced cardiovascular disease as the leading cause of death. The proportion of deaths due to dementia increased overall, from 2% in 2002 to over 7% in 2019, and across all age groups, notably from 1% to 4% in those aged 70–79. The proportion of deaths due to falls and Parkinson's disease also increased.ConclusionsThere has been a shift of causes of death among those with diabetes away from cardiovascular disease. The proportion of deaths due to conditions such as dementia and falls is increasing among those with diabetes, which will require consideration when planning future resource allocation.
Diabetes knowledge, self‐efficacy and dietary, psychological and physical health barriers: Comparing young and usual‐onset type 2 diabetes
Authors: Wong Sabrina K. W. , Soon Winnie , Griva Konstadina , Smith Helen Elizabeth 
Published: August 2023

AbstractAimsYoung‐onset (21–39 years old) type 2 diabetes (YOD) is associated with high complication rates and glycaemic levels, and poor self‐management plays a significant role. Knowledge, skills and barriers influence self‐management behaviours considerably. Therefore, this study assessed diabetes knowledge, self‐efficacy and barriers (situational dietary barriers, physical health, mental health and diabetes‐related distress) between participants with young and usual‐onset (40–59 years old) (UOD) diabetes.MethodologyA cross‐sectional survey was conducted. Differences between YOD and UOD were analysed using bivariate analysis and effect sizes were estimated with Cohen's d. Differences were further adjusted by demographic factors (gender, ethnicity, marital status, educational level, income level) and diabetes duration.ResultsA total of 409 (97 YOD, 312 UOD) participants were recruited. Participants with YOD had lower self‐efficacy levels (adjusted B = –0.19, CI –0.35 to −0.03) and higher dietary barriers (adjusted B = 3.6, CI 2.1–5.1), lower mental health scores (adjusted B = –3.5, CI –5.7 to −1.4) and higher diabetes‐related distress levels (adjusted B = 0.2, CI 0.2–0.4).ConclusionsOur study found that participants with YOD faced more challenges with adapting to life with diabetes when compared with UOD. More effective self‐management programmes are needed to support the multifaceted needs of adults with YOD.
Retail pricing format and rigidity of regular prices
Authors: Ray Sourav , Snir Avichai , Levy Daniel 
Published: August 2023

AbstractWe study the rigidity of regular and sale prices, and how it is affected by pricing formats (i.e. pricing strategies). We use data from three large Canadian stores with different pricing formats (Every‐Day‐Low‐Price, Hi‐Lo and Hybrid) that are located within a 1 km radius of each other. Our data contain both the actual transaction prices and actual regular prices as displayed on the store shelves. We combine these data with two ‘generated’ regular price series (filtered prices and reference prices) and study their rigidity. Regular price rigidity varies with store formats because different format stores treat sale prices differently, and consequently define regular prices differently. Correspondingly, the meanings of price cuts and sale prices vary across store formats. To interpret the findings, we consider the store pricing format distribution across the USA and Canada.
Congenital anomalous drainage of the inferior vena cava and hepatic veins into the left atrium associated with long QT syndrome: Multimodality imaging, pitfalls, and caveats
Authors: Malakan Rad Elaheh , Radmehr Hassan , Taghizadeh Ashkan , Pouraliakbar Hamidreza 
Published: August 2023

AbstractIsolated congenital anomalous drainage of the inferior vena cava (IVC) and partial hepatic veins (HV) into the left atrium (LA) via an interatrial communication (IAC), associated with the normal connection of the IVC to the right atrium is exceedingly rare. Therefore, there is a dearth of knowledge regarding the management of these cases. To date, there has been no report of abnormal IVC drainage caused by abnormal IVC‐IAC alignment. Much more frequently, patients have an abnormal connection or abnormal drainage mediated by a persistent Eustachian valve that allows blood to pass from the inferior vena cava to the left atrium. Herein, we report an 8‐year‐old boy with anomalous IVC and hepatic vein drainage into the LA due to IVC‐IAC malalignment. We describe the findings of multimodality imaging, including transthoracic, transesophageal, contrast, and speckle‐tracking echocardiography, cardiac angiography, and cardiac magnetic resonance imaging. We go over the diagnostic and therapeutic pitfalls and caveats of this case that can apply to similar patients.
A simple nudge increases socioeconomic diversity in undergraduate Economics
Authors: Pugatch Todd , Schroeder Elizabeth 
Published: August 2023

AbstractWe assess whether a light‐touch intervention can increase socioeconomic and racial diversity in undergraduate Economics. We randomly assigned over 2200 students a message with basic information about the Economics major; the basic message combined with an emphasis on the rewarding careers or financial returns associated with the major; or no message. Messages increased the proportion of first generation students majoring in Economics by five percentage points. This effect size was sufficient to reverse the gap in Economics majors for first generation students. Suggestive evidence indicates the effects may be driven by first generation students who were not also underrepresented minorities.
Sartre, Kant, and the spontaneity of mind
Authors: Apostolopoulos Dimitris 
Published: August 2023

AbstractI argue that Sartre's Transcendence of the Ego draws on Kant's theory of spontaneity to articulate its metaphysical account of consciousness's mode of being, to defend its phenomenological description of the intentional structure of self‐consciousness, and to diagnose the errors that motivate views of consciousness qua person or substance. In addition to highlighting an overlooked dimension of Sartre's early relation to Kant, this interpretation offers a fresh account of how Sartre's argument for the primacy of pre‐personal consciousness works, and brings the extent of his proximity to idealist models of mind into greater relief. It also affords Sartre the resources to respond to criticisms that his account of self‐consciousness relies on a spurious distinction and that his view of freedom cannot explain how consciousness is conditioned by its world.
How temperature and aridity drive lignin decomposition along a latitudinal transect in western Siberia
Authors: Dao Thao Thi , Mikutta Robert , Wild Birgit , Sauheitl Leopold , Gentsch Norman , Shibistova Olga , Schnecker Jörg , Lashchinskiy Nikolay , Richter Andreas , Guggenberger Georg 
Published: August 2023

AbstractClimate change drives a northward shift of biomes in high‐latitude regions. This might have consequences on the decomposition of plant litter entering the soil, including its lignin component, which is one of the most abundant components of vascular plants. In order to elucidate the combined effect of climate and soil characteristics on the decomposition pattern of lignin, we investigated lignin contents and its degree of oxidative decomposition within soil profiles along a climosequence in western Siberia. Soil samples were collected from organic topsoil to mineral subsoil at six sites along a 1500‐km latitudinal transect, stretching from tundra, through taiga and forest steppe to typical steppe. The stage of lignin degradation, as mirrored by decreasing organic carbon‐normalized lignin contents and increasing oxidative alteration of the remnant lignin (acid‐to‐aldehyde ratios of vanillyl‐ and syringyl‐units [(Ac/Al)V and (Ac/Al)S]) within soil horizons, increased from tundra to forest steppe and then decreased to the steppe. Principal component analysis, involving also climatic conditions such as mean annual temperature and aridity index, showed that the different states of lignin degradation between horizons related well to the activity of phenoloxidases and peroxidases, enzymes involved in lignin depolymerization that are produced primarily by fungi and less importantly by bacteria. The low microbial lignin decomposition in the tundra was likely due to low temperature and high soil moisture, which do not favour the fungi. Increasing temperature and decreasing soil moisture, facilitating a higher abundance of fungi, led to increased fungal lignin decomposition towards the forest‐steppe biome, while drought and high pH might be responsible for the reduced lignin decomposition in the steppe. We infer that a shift of biomes to the north, driven by climate change, might promote lignin decomposition in the northern parts, whereas in the south a further retardation might be likely.
Efficacy of bioactive materials in preventing Streptococcus mutans‐induced caries on enamel and dentine
Authors: Contreras Sheila Mondragón , Fernandes Juliana Benace , Spinola Manuela da Silva , Garcia Maíra Terra , Junqueira Juliana Campos , Bresciani Eduardo , Caneppele Taciana Marco Ferraz 
Published: August 2023

AbstractThe study investigated the ability of bioactive materials used to restore enamel and dentine specimens to prevent caries. Enamel (n = 50) and dentine (n = 50) specimens were obtained from bovine incisors, prepared, and randomly allocated to one of five groups according to the restorative treatment: alkasite without adhesive system; alkasite with adhesive system; high viscosity glass ionomer cement; resin composite; no restoration; negative control group. Specimens were restored, exposed to a thermal cycling aging protocol, sterilized, and exposed to a cariogenic challenge induced by Streptococcus mutans and then submitted to surface and subsurface microhardness tests and polarized light microscopy to verify the caries lesion development in enamel or dentine surrounding the restorative materials. Data were analyzed using one‐way ANOVA. In enamel and dentine, glass ionomer cement, alkasite without and with adhesive system presented a lower percentage surface microhardness loss than resin composite and negative control. Enamel subsurface microhardness presented no statistically significant differences between glass ionomer cement, alkasite without and with adhesive system. Glass ionomer cement also did not present statistically significant differences from resin composite and the negative control. In dentine, glass ionomer cement showed the highest subsurface microhardness values. In conclusion, bioactive restorative materials provide greater protection to enamel and dentine against surface caries development than resin composite.