bluuebunny/crossref_metadata_2025_split huggingface dataset:
Feasibility of peripheral blood stem cell collection from sickle cell trait donors with an intensified G‐CSF regimen
Authors: Mohrez Morad , Troeger Anja , Kleinschmidt Katharina , Alali Tarek Hanafee , Jakob Marcus , Brosig Andreas , Hähnel Viola , Kietz Silke , Offner Robert , Burkhardt Ralph , Corbacioglu Selim , Ahrens Norbert , Foell Juergen 
Published: August 2023

AbstractObjectivesAllogeneic hematopoietic stem cell transplantation (HSCT) is the only curative treatment for SCD and bone marrow from an HLA‐matched sibling is currently the standard of care. Haploidentical HSCT from a family donor with a TCR αβ/CD19 depleted graft (T‐haplo) is an increasingly successful alternative, which requires the generation of G‐CSF stimulated peripheral stem cell (PBSC) from haploidentical relatives. These sickle cell trait (SCT) donors reported to develop SCD‐related complications in conditions of severe stress.MethodsIn this retrospective analysis, we compared the safety and efficacy of PBSC mobilization with a G‐CSF intensified mobilization regimen in SCT donors with a conventional G‐CSF mobilization regimen in healthy donors.ResultsThe reported adverse events were similar during intensified G‐CSF mobilization, apheresis, and shortly after stem cell apheresis in SCT and control donors. In SCT and control donors, we were able to mobilize high yields of CD34+ stem cells and the harvested CD34+ cell count was comparable with control donors.ConclusionsPeripheral stem cell mobilization using an intensified G‐CSF regimen is safe, and well tolerated among SCT donors. SCT donors are a valid alternative for collection of peripheral CD34+ stem cells for T‐cell‐depleted haploidentical stem cell transplantation.
Corollary discharge function in healthy controls: Evidence about self‐speech and external speech processing
Authors: Beño‐Ruiz‐de‐la‐Sierra Rosa M. , Arjona‐Valladares Antonio , Fondevila Estevez Sabela , Fernández‐Linsenbarth Inés , Díez Álvaro , Molina Vicente 
Published: August 2023

AbstractAs we speak, corollary discharge mechanisms suppress the auditory conscious perception of the self‐generated voice in healthy subjects. This suppression has been associated with the attenuation of the auditory N1 component. To analyse this corollary discharge phenomenon (agency and ownership), we registered the event‐related potentials of 42 healthy subjects. The N1 and P2 components were elicited by spoken vowels (talk condition; agency), by played‐back vowels recorded with their own voice (listen‐self condition; ownership) and by played‐back vowels recorded with an external voice (listen‐other condition). The N1 amplitude elicited by the talk condition was smaller compared with the listen‐self and listen‐other conditions. There were no amplitude differences in N1 between listen‐self and listen‐other conditions. The P2 component did not show differences between conditions. Additionally, a peak latency analysis of N1 and P2 components between the three conditions showed no differences. These findings corroborate previous results showing that the corollary discharge mechanisms dampen sensory responses to self‐generated speech (agency experience) and provide new neurophysiological evidence about the similarities in the processing of played‐back vowels with our own voice (ownership experience) and with an external voice.
Overcoming traditional ETL systems architectural problems using a service‐oriented approach
Authors: Oliveira Bruno , Oliveira Óscar , Belo Orlando 
Published: August 2023

AbstractDeveloping analytical systems imposes several challenges related not only to the amount and heterogeneity of the involved data but also to the constant need to readapt and evolve to overcome new business challenges. Data are a determinant factor in the success of analytical and decision‐making applications, being its nature, availability, and quality, crucial aspects for planning and structuring populating analytical systems. Today's users are more demanding, requiring adaptable and flexible analytical applications, which impose serious challenges on extract‐transform‐load (ETL) systems design and development for ensuring flexible and robust data populating services, operating 24/7, and managing and processing large volumes of data. Thus, we should design and implement ETL processes using innovative and up‐to‐date approaches, having real application evidence. In this paper, we present a service‐oriented implementation for ETL design and development. We mapped and implemented some of the most conventional ETL processes in a service‐oriented architecture, to demonstrate the application and benefits that this kind of approach will provide to ETL systems project development.
Joint dynamics of stock returns and cash flows: A time‐varying present‐value framework
Authors: Yu Deshui , Yan Yayi 
Published: August 2023

AbstractThis paper proposes a novel time‐varying present‐value model to analyze the joint dynamics of stock returns and cash flows periodically. We use a nonparametric time‐varying vector autoregressive model to examine the economic implications of the time‐varying present‐value model. By conducting several nonparametric tests, we reject the stability of multivariate forecasting models and the null that stock returns and cash flows are simultaneously unpredictable in any given period. Additional bootstrap analyses show that under the null of unpredictable returns, dividend growth is highly predictable. Finally, the proposed time‐varying present‐value framework holds robustly for both the dividend–price ratio and the earnings–price ratio.
Comparison of halitosis according to herbal mouthwash containing Glycyrrhiza uralensis extract and saline mouthwash: A randomized, double‐blind, placebo‐controlled study
Authors: Kim Yu‐Rin , Nam Seoul‐Hee 
Published: August 2023

AbstractObjectivesThis study was conducted in order to determine the effect on halitosis and the antibacterial effect against halitosis‐causing bacteria of the mouthwash made of the natural material, Glycyrrhiza uralensis (G. uralensis) extract.Materials and MethodsA randomized, double‐blind, placebo‐controlled study was conducted on 60 patients who visited M dental clinic located in Busan, South Korea, excluding those with systemic disease that may induce halitosis. There were 30 patients classified to the saline gargle group and the remaining 30 patients were classified to the G. uralensis extract gargle group. In addition, their level of halitosis and halitosis‐causing bacteria were measured. They visited the dental clinic on a fasted state at baseline before gargle application (Baseline), immediately after gargle application (Treatment) and 5 days after gargle application (After 5 Days). For clinical indicators, participants were tested for halitosis and bacteria immediately after waking up without brushing their teeth and without hydration.ResultsThe prevalence of halitosis decreased in the G. uralensis extract gargle group compared to the saline gargle group at Treatment and After 5 Days. In cases with pseudo halitosis, there was a significant decrease in halitosis‐causing bacteria when G. uralensis extract gargle was applied (p < 0.05).ConclusionsIt was identified that using a mouthwash made with G. uralensis extract is effective for halitosis improvement and reduction of halitosis‐causing bacteria. Therefore, using a mouthwash containing G. uralensis extract, it will be effective in improving bad breath and oral hygiene will be possible.
Motivations for and outcomes of graduate education amongst dental hygienists: A pan‐Canadian study
Authors: Rock Leigha D. , Macdonald Lindsay K. , Compton Sharon M. , MacDonald Laura L. , Kanji Zul 
Published: August 2023

AbstractObjectivesMotivations and career outcomes of dental hygienists with baccalaureate degrees have been recently reported; however, few studies have explored Canadian dental hygienists pursuing graduate education. There is limited evidence to inform career outcomes and motivating factors for advanced education, limiting knowledge of how professional outcomes have evolved alongside advancements in graduate program offerings. This study focused on understanding motivating factors to pursue graduate education and the professional outcomes of dental hygienists with graduate degrees.MethodsThis nested online anonymous survey was conducted between November and December 2021 with dental hygienists who graduated from one of four Canadian baccalaureate‐level dental hygiene degree programs and had further indicated that they were pursuing or had obtained additional graduate‐level education (n = 60). Participants were asked to report on any advanced graduate‐level education. Open‐ended questions on graduate degree education were analysed through thematic analysis.ResultsMotivations for pursuing graduate degrees were influenced by personal and professional preferences. Master's degree recipients cited expanded career opportunities, alternate interests, convenience, and dissatisfaction with/desire to leave clinical practice as major motivators. Doctoral degree holding dental hygienists identified expanded/alternate career opportunities as major motivation but also cited program convenience as an influencer. The availability of distance and flexible programming is a novel finding that positively influences the pursuit of advanced education.ConclusionDental hygienists are pursuing graduate education to expand their scope of knowledge and create new career opportunities. Graduate degree programs that accommodate work–life balance through flexible and online offerings are very attractive to dental hygienists.
Using the learning disability screening questionnaire to help identify people with an intellectual disability in homeless services
Authors: McKenzie Karen , Murray George , Metcalfe Dale , Robson Ruth , Kaczmar Matt , Shirley Alex 
Published: August 2023

AbstractBackgroundWe explored the accuracy of using the learning disability screening questionnaire (LDSQ) in services for people experiencing homelessness in the United Kingdom.MethodWe examined the concordance between the LDSQ outcomes and assessments of intellectual disability. Seventy adults experiencing homelessness completed the LDSQ. Staff completed the LDSQ and a measure of adaptive functioning for 38 of this group. Nine participants received an intellectual assessment.ResultsSensitivity and specificity for the LDSQ when completed by staff was 83% and 96% respectively and 50% and 92% when completed by the individual. Seven people had intellectual and adaptive functioning in the intellectual disability range.ConclusionThe results suggest that the LDSQ would be an appropriate and beneficial screening tool to use within services for people experiencing homelessness. More accurate results would be likely if it were completed by staff.
Blackspotted rockskippers (Entomacrodus striatus) avoid refuges with conspecifics
Authors: Brainard Miranda K. , Swango Caitlyn P. , Houglan Paityn M. , Londraville Richard L. 
Published: August 2023

AbstractDuring an escape from predators, many animals need to evaluate and choose a refuge within seconds. We investigated refuge choice in the amphibious blackspotted rockskipper, Entomacrodus striatus, in Moorea, French Polynesia. Rockskippers are small combtooth blennies that inhabit rocky beaches and jetties at the aquatic/terrestrial interface. They are conspicuous for their eponymous jumping to/from refugia among rocks when threatened. We have observed refugia with both multiple conspecifics and solitary fish in the field, and here tested whether fish choose refugia that are occupied by conspecifics in the laboratory. E. striatus chose unoccupied refugia on the opposite side of the experimental tank in 11/14 trials, a significantly greater number of times than they chose occupied refugia. In 3/14 trials, fish chose occupied refugia, indicating that refuge occupation does not prohibit their use by conspecifics. We hypothesize that chemical stress signals from the occupying fish deter most fish from choosing the same refuge.
Glycemic control and diabetes complications across health status categories in older adults treated with insulin or insulin secretagogues: The Diabetes & Aging Study
Authors: Lipska Kasia J. , Huang Elbert S. , Liu Jennifer Y. , Parker Melissa M. , Laiteerapong Neda , Grant Richard W. , Moffet Howard H. , Karter Andrew J. 
Published: August 2023

AbstractBackgroundFor older adults with type 2 diabetes (T2D) treated with insulin or sulfonylureas, Endocrine Society guideline recommends HbA1c between 7% to <7.5% for those in good health, 7.5% to <8% for those in intermediate health, and 8% to <8.5% for those in poor health. Our aim was to examine associations between attained HbA1c below, within (reference), or above recommended target range and risk of complication or mortality.MethodsRetrospective cohort study of adults ≥65 years old with T2D treated with insulin or sulfonylureas from an integrated healthcare delivery system. Cox proportional hazards models of complications during 2019 were adjusted for sociodemographic and clinical variables. Primary outcome was a combined outcome of any microvascular or macrovascular event, severe hypoglycemia, or mortality during 12‐month follow‐up.ResultsAmong 63,429 patients (mean age: 74.2 years, 46.8% women), 8773 (13.8%) experienced a complication. Complication risk was significantly elevated for patients in good health (n = 16,895) whose HbA1c was above (HR 1.97, 95% CI 1.62–2.41) or below (HR 1.29, 95% CI 1.02–1.63) compared to within recommended range. Among those in intermediate health (n = 30,129), complication risk was increased for those whose HbA1c was above (HR 1.45, 95% CI 1.30–1.60) but not those below the recommended range (HR 0.99, 95% CI 0.89–1.09). Among those in poor health (n = 16,405), complication risk was not significantly different for those whose HbA1c was below (HR 0.98, 95% CI 0.89–1.09) or above (HR 0.96, 95% CI 0.88–1.06) recommended range.ConclusionsFor older adults with T2D in good health, HbA1c below or above the recommended range was associated with significantly elevated complication risk. However, for those in poor health, achieving specific HbA1c levels may not be helpful in reducing the risk of complications.
Function and regulation of cis P‐tau in the pathogenesis and treatment of conventional and nonconventional tauopathies
Authors: Wang Ruizhi , Lu Kun Ping , Zhou Xiao Zhen 
Published: August 2023

AbstractConventional tauopathies are a group of disease characterized by tau inclusions in the brains, including Alzheimer's disease (AD), Pick's disease (PiD), progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), and certain types of frontotemporal dementia (FTD), among which AD is the most prevalent. Extensive post‐translational modifications, especially hyperphosphorylation, and abnormal aggregation of tau protein underlie tauopathy. Cis–trans isomerization of protein plays an important role in protein folding, function, and degradation, which is regulated by peptidyl‐proline isomerases (PPIases). Peptidyl‐prolyl cis–trans isomerase NIMA‐interacting 1 (Pin1), the only PPIase found to isomerize Pro following phosphorylated Ser or Thr residues, alters phosphorylated tau protein conformation at pT231‐P motif. The cis P‐tau but not trans P‐tau serves as an early driver of multiple neurodegenerative disease, encompassing AD, traumatic brain injury (TBI), chronic traumatic encephalopathy (CTE), and vascular contributions to cognitive impairment and dementia (VCID). Cis but not trans P‐tau is resistant to protein dephosphorylation and degradation, and also prone to protein aggregation. Cis P‐tau loses its ability to stabilize microtubule, causing and spreading tauopathy mainly in axons, a pathological process called cistauosis. The conformation‐specific monoclonal antibody that targets only the cis P‐tau serves as a very early diagnosis method and a potential treatment of not only conventional tauopathies but also nonconventional tauopathies such as VCID, with clinical trials ongoing. Notably, cis P‐tau antibody is the only clinical‐stage Alzheimer's therapeutic that has shown the efficacy in animal models of not only AD but also TBI and stroke, which are very early stages of dementia. Here we review the identification and pathological consequences of cis pt231‐tau, the role of its regulator Pin1, as well as the clinical implication of cis pt231‐tau conformation‐specific antibody in conventional and nonconventional tauopathies.image
The evolution of family policies and couples' housework division after childbirth in Germany, 1994–2019
Authors: Zoch Gundula , Heyne Stefanie 
Published: August 2023

AbstractObjectiveWe examine how the re‐traditionalization effect of childbirth on couples' division of housework has evolved over time as a result of major family policy change.BackgroundSupportive family policies are associated with a more egalitarian division of labor. However, it remains unclear how a country's transition from a modernized male breadwinner regime that supports maternal care to family policies that promote maternal employment and paternal caregiving change couples' gender‐typical division of housework in the long run.MethodWe use representative survey data from the German Socio‐Economic Panel (1994–2019, N = 14,648) and estimate the re‐traditionalization effect of childbirth on mothers' absolute and relative time‐use on housework over four policy periods with linear fixed‐effects regression models.ResultsAcross all periods, mothers took on larger absolute and relative levels of housework after childbirth, with a more pronounced and persistent gender‐typical division in West than in East Germany. However, mothers spent somewhat less absolute and relative time on housework in recent periods with stronger levels of de‐familiarizing and dual‐earner/dual‐carer policies than in earlier periods with policies supporting maternal caregiving.ConclusionWe find somewhat smaller and less persistent re‐traditionalization effects of childbirth in more supportive work–family policy periods. In sum, the small changes illustrate that even in contexts of enormous policy change, progress toward a less gender‐typical division of housework has been slow and rather small.
Prevalence of temporomandibular disorders (TMD) in obesity patients: A systematic review and meta‐analysis
Authors: Minervini Giuseppe , Franco Rocco , Marrapodi Maria Maddalena , Almeida Luis Eduardo , Ronsivalle Vincenzo , Cicciù Marco 
Published: August 2023

AbstractObjectiveObesity is a growing epidemic in the world. It increases the risk for severe health conditions, including diabetes, heart disease and stroke. Recent research has found that obesity is associated with an increased risk for temporomandibular disorders (TMDs). The purpose of this literature review with meta‐analysis is to analyse the possible association between obesity and temporomandibular disorders.Materials and MethodsPubmed, Web of Science and Lilacs were systematically searched until 01/03/2000. Articles dealing with TMD and obesity were selected, and numbers that might be useful in the meta‐analysis were extracted.ResultsFifty articles were chosen after using all three search engines. Thirty‐five articles were considered during the initial screening step. Four papers were chosen for title and abstract screening based on the PECO model. A manual search of bibliographies and the Cochrane database was also carried out, but no publications that matched the inclusion criteria were located. The articles and meta‐analysis did not show a clear association between obesity and temporomandibular disorders.ConclusionThere is no evidence regarding the reliability of either method. Both have superimposable results.
Review of outpatient procedural sedation clinics in a tertiary paediatric hospital in South Australia
Authors: Jung‐Tang Nicole , Agrawal Rishi , Battersby Ailish , Burgoyne Laura , Louise Jennie , Cheung Abigail 
Published: August 2023

AimProcedures, such as immunisation and venepuncture, can be distressing for paediatric patients, especially those with needle phobia and neurodevelopmental disorders. Procedural sedation helps provide access to equitable health care in this population. The aim of this study was to evaluate the pilot outpatient procedural sedation clinics at the Women's and Children's Hospital and the impact on patient care and outcomes.MethodsA prospective review was undertaken between July 2021 and May 2022 on all patients who attended the procedural sedation clinics at the Women's and Children's Hospital. These clinics were the COVID Specialist Immunisation Sedation Clinic (SISC) and Paediatric Sedation Clinic (PSC).ResultsThere were 182 visits in a total of 110 children with a 92% primary procedure success rate. Sixty‐three per cent of patients had neurodevelopmental disorders with autism spectrum disorder being most common. There was a significant reduction in anxiety scores pre‐ and post‐sedation and a reduction in anxiety scores if patients were to return without the use of sedation.ConclusionsOutpatient procedural sedation is beneficial for a specific cohort of the paediatric population. This can also have a significant positive impact on patient care and potentially, long‐term outcomes.
Community‐based art groups in mental health recovery: A systematic review and narrative synthesis
Authors: Goodman‐Casanova Jessica Marian , Guzman‐Parra Jose , Mayoral‐Cleries Fermin , Cuesta‐Lozano Daniel 
Published: August 2023

AbstractIntroductionThough the evidence of the role of the arts in mental health is growing, no systematic review has focused on the impact of art groups in non‐clinical settings in the process of recovery following the CHIME framework.AimThe aim of this study was to examine the effects of engaging in community‐based art groups in mental health recovery.MethodA search in five electronic databases for relevant research using quantitative, qualitative or mixed methods published between 2000 and 2019 identified nine eligible studies.ResultsWhile there was great methodological heterogeneity, most studies were qualitative, used visual arts, facilitated by artists and assessed by mental health nurses, and took place in community locations or artistic venues. Quantitative outcomes, though few, provided evidence of increased well‐being, and qualitative outcomes corresponded mostly with the recovery process of Connectedness. Additional outcomes related to the settings were a sense of safety and to the intervention: self‐expression, development of skills and achievements, and the impact of final exhibitions and peer leadership.DiscussionStudies should aim at prospective designs following mixed methods approaches, with larger and gender‐sensitive samples, control groups and follow‐up assessments, and evaluate cost‐effectiveness.Implications for practiceCommunity‐based art groups which increase well‐being and promote connectedness should be key in recovery‐action planning.