bluuebunny/crossref_metadata_2025_split huggingface dataset:
Study of cell protective effects of alcohols against UV-C radiation and comparison to gamma radiation
Authors: Neužilová Barbora , Čuba Václav , Crhánová Michaela , Múčka Viliam 
Published: January 2023

AbstractA singlet oxygen production was monitored using a singlet oxygen sensor green chemical probe; reaction of chemical probe with singlet oxygen produces a fluorescent endoperoxide. Adding ethanol to the irradiated system resulted in decrease of the fluorescence signal, which indicates a decrease in concentration of singlet oxygen formed under UV-C irradiation. Thus, ethanol was likely to quench singlet oxygen in a system under study. This quenching did not occur with the use of methanol. When irradiating E. coli cells in the presence of ethanol and Rose Bengal for higher singlet oxygen production, there was a greater reduction in the radiation sensitivity of the cells compared to the system without Rose Bengal. Higher concentration of ethanol caused greater protection of cells; thus, it is likely that ethanol can scavenge singlet oxygen and provide a partial protection of bacteria from the effects of UV-C radiation. These results were compared with previously published data where the bacteria were irradiated by gamma radiation in presence of alcohols.
A new set of estimated cardiorespiratory fitness equations are associated with cognitive performance in older adults
Authors: Velázquez-Díaz Daniel , Cadenas-Sanchez Cristina , Molina-Guzmán Flor Abril , Sáenz-Carrasco Jesús Alfredo , Gonzalez-Rosa Javier J. , Erickson Kirk I. , Carbonell-Baeza Ana , Jiménez-Pavón David 
Published: January 2023

Abstract
This study aimed to develop new equations to estimate cardiorespiratory fitness specifically for older adults and, secondly, to analyze the associations of cardiorespiratory fitness, both objectively measured and estimated using new equations, with cognitive performance. Ninety-two older adults (41 females, 65–75 years) from baseline data of a randomized controlled trial were analyzed (“ClinicalTrials.gov” Identifier: NCT03923712). Participants completed 4 measurement sessions including (i) physiological and health indicators in a laboratory setting, (ii) field-based fitness tests, (iii) sociodemographic and physical activity questionnaires, and (iv) a battery of neuropsychological tests to evaluate cognitive performance. The main findings were as follows: (i) a set of new equations with good predictive value for estimated cardiorespiratory fitness were developed (74–87%), using different scenarios of complexity and/or equipment requirements, and (ii) higher estimated cardiorespiratory fitness, even using its simplest equation (eCRF =  − 1261.99 + 1.97 × 6 min walking test (m) + 1.12 × bioimpedance basal metabolic rate (kcal/day) + 5.25 × basal heart rate (bpm)), was associated with better cognitive performance evaluated by several neuropsychological tests (i.e., language, cognitive flexibility, fluency, attention, and working memory), similar to using objectively measured cardiorespiratory fitness. In summary, a new set of estimated cardiorespiratory fitness equations have been developed with predictive values ranging from 74 to 87% that could be used based on necessity, availability of equipment, resources, or measurement context. Moreover, similar to objectively measured cardiorespiratory fitness, this measure of estimated cardiorespiratory fitness was positively associated with performance on language, fluency, cognitive flexibility, attention, and working memory, independently of sex, age, and education level.
Comparison of Hydrodynamic Performances Between Single Pontoon and Double Pontoon Floating Breakwaters Through the SPH Method
Authors: Chen Yong-kun , Liu Yong , Meringolo Domenico D. 
Published: January 2023

AbstractA numerical study adopting the 2D δ-SPH model is performed to compare the hydrodynamic characteristics of a single pontoon floating breakwater and a double pontoon floating breakwater. Numerical simulations are performed using the δ-SPH model and experimental tests are conducted to validate the numerical model. The numerical results of both the free surface elevations and motions of the floating breakwater are in good agreement with the experimental results. Numerical results show that when the pontoon drafts are larger, the double pontoon floating breakwater performs better in wave attenuations compared with the single pontoon floating breakwater, and for all the drafts, the amplitudes of motions including sway, heave and roll of the double pontoon floating breakwater is always smaller. In addition, increasing the spacing between the two pontoons can further reduce the amplitudes of pontoon motions and improve the wave attenuation ability of the double pontoon floating breakwater.
Investigation on Effects of Mooring Line Fractures and Connector Failures for A Hybrid Modular Floating Structure System
Authors: Liu Ya-qiong , Ren Nian-xin , Ou Jin-ping 
Published: January 2023

AbstractThe present work reports a Hybrid Modular Floating Structure (HMFS) system with typical malfunction conditions. The effects of both fractured mooring lines and failed connectors on main hydrodynamic responses (mooring line tensions, module motions, connector loads and wave power production) of the HMFS system under typical sea conditions are comparatively investigated. The results indicate that the mooring tension distribution, certain module motions (surge, sway and yaw) and connector loads (Mz) are significantly influenced by mooring line fractures. The adjacent mooring line of the fractured line on the upstream side suffers the largest tension among the remaining mooring lines, and the case with two fractured mooring lines in the same group on the upstream side is the most dangerous among all cases of two-line failures in view of mooring line tensions, module motions and connector loads. Therefore, one emergency strategy with appropriate relaxation of a proper mooring line has been proposed and proved effective to reduce the risk of more progressive mooring line fractures. In addition, connector failures substantially affect certain module motions (heave and pitch), certain connector loads (Fz and My) and wave power production. The present work can be helpful and instructive for studies on malfunction conditions of modular floating structure (MFS) systems.
Bioacoustic evidence for a continuous summer presence of the greater noctule bat, Nyctalus lasiopterus, in the Italian Alps
Authors: Paniccia Chiara , Zingg Peter E. , Bellè Alex , Hilpold Andreas , Reichegger Florian , Tappeiner Ulrike , Ladurner Eva 
Published: January 2023

AbstractThe greater noctule bat, Nyctalus lasiopterus (Schreber, 1780), is one of the rarest bat species in Europe. Data on its distribution in the central and western parts of the continent are largely lacking. For the first time, N. lasiopterus was observed in South Tyrol (Northern Italy) using bat detectors in the summer of 2016 and in the following years until 2021. The five sites where the species was detected are located in a limited area of the Adige Valley, which is characterised by low elevation and a mild climate. Multiple recordings indicated a continuous summer presence of N. lasiopterus on the southern side of the Alps. Additionally, we present insights on echolocation and species identification, including statistically significant differences in the call metrics of N. lasiopterus compared to Tadarida teniotis. These results are important at a European level given that data is lacking on the populations of N. lasiopterus in Europe outside the Mediterranean.
Tools for assessing teacher digital literacy: a review
Authors: Nguyen Lan Anh Thuy , Habók Anita 
Published: January 2023

AbstractWith the rapid advancement of technology, digital literacy has become a key component in educators’ professional development. A wide range of assessment tools has been developed to measure teacher digital literacy; however, there has been no previous attempt to systematically synthesize and scrutinize those tools to improve evaluation of this ability among educators. The current study reviews literature on instruments that assess teacher digital literacy with the purposes of ascertaining the main aspects of it that recent researchers focus on in their evaluation, instrument types used for assessment, and the reliability and validity report, as well as the frameworks or models used to design assessment tools. The review selected 33 English-language publications in the field of educational technology from peer-reviewed journals indexed in the Education Resources Information Center (ERIC), Web of Science, and Scopus. The study period spanned from 2011 to 2022 with the objective of reviewing the tools used to assess teacher digital competence. The major findings demonstrate that scholars focus on digital competence in teachers’ use of educational technology, teaching and learning, professional development, and support for learners through digital competence. Other researchers emphasize the ability of educators to apply technology to the assessment of learner outcomes or to empower students in using technology to enhance learning. Additionally, self-evaluation instruments are common, whereas a few studies promote subjective evaluation in combination with objective assessment to provide a comprehensive understanding of teacher digital competence. The results form the basis for several recommendations for future research for the further examination of teacher digital literacy.
Photocatalytic activity of P-doped TiO2 photocatalyst
Authors: Rescigno Raffaella , Sacco Olga , Venditto Vincenzo , Fusco Alessandra , Donnarumma Giovanna , Lettieri Mariateresa , Fittipaldi Rosalba , Vaiano Vincenzo 
Published: January 2023

AbstractIn this study, P-doped TiO2 photocatalysts with different molar percentages (in the range 0.071–1.25 mol %) of the non-metallic element were prepared and their photocatalytic activity under visible light irradiation was tested. All achieved samples were characterized by XRD, Raman, UV–Vis DRS and SEM–EDX techniques. XRD and Raman analysis showed that all doped photocatalysts were in anatase phase and evidenced that P ions were successfully incorporated into the TiO2 crystal lattice, affecting also the crystallinity degree of the P-doped TiO2 photocatalysts. Noticeably, the UV–Vis DRS spectra evidenced that the highest redshift in absorption edge was observed for the photocatalyst with the lowest P content (0.071PT), which showed also the lowest bandgap (2.9 eV). The photocatalytic performances of all P-doped TiO2 samples were compared with that of commercial TiO2 by evaluating the decolorization of methylene blue (MB) dye under visible light irradiation. Results showed that phosphorus doping strongly promoted photocatalytic activity in the presence of visible light. Furthermore, the most active photocatalyst in visible light tests (0.071PT) also showed better photocatalytic activity than commercial TiO2 in the decolorization of MB under simulated sunlight irradiation. Finally, 0.071PT photocatalyst was preliminarily tested against Escherichia coli (E. coli) under simulated solar light, showing an inactivation efficiency of 90% after 2 h of treatment time.
Graphical abstract
Phase I Study of Safety and Pharmacokinetics of RO7297089, an Anti-BCMA/CD16a Bispecific Antibody, in Patients with Relapsed, Refractory Multiple Myeloma
Authors: Plesner Torben , Harrison Simon J. , Quach Hang , Lee Cindy , Bryant Adam , Vangsted Annette , Estell Jane , Delforge Michel , Offner Fritz , Twomey Patrick , Choeurng Voleak , Li Junyi , Hendricks Robert , Ruppert Shannon M. , Sumiyoshi Teiko , Miller Karen , Cho Eunpi , Schjesvold Fredrik 
Published: January 2023

Abstract
Introduction
This phase 1 trial assessed the safety, pharmacokinetics, and preliminary antitumor activity of RO7297089, an anti-BCMA/CD16a bispecific antibody.

Methods
RO7297089 was administered weekly by intravenous infusion to patients with relapsed/refractory multiple myeloma. The starting dose was 60 mg in this dose-escalation study utilizing a modified continual reassessment method with overdose control model.

Results
Overall, 27 patients were treated at doses between 60 and 1850 mg. The maximally administered dose was 1850 mg due to excipients in the formulation that did not allow for higher doses to be used. The maximum tolerated dose was not reached. The most common adverse events irrespective of grade and relationship to the drug were anemia, infusion-related reaction, and thrombocytopenia. Most common treatment-related grade ≥ 3 toxicities were ALT/AST increase and reduced lymphocyte count. Pharmacokinetic studies suggested non-linear pharmacokinetics and target-mediated drug disposition, with a trend of approaching linear pharmacokinetics at doses of 1080 mg and higher. Partial response was observed in two patients (7%), minimal response in two patients (7%), and stable disease in 14 patients (52%).

Conclusions
RO7297089 was well tolerated at doses up to 1850 mg, and the efficacy data supported activity of RO7297089 in multiple myeloma. Combination with other agents may further enhance its potential as an innate immune cell engager in multiple myeloma.

Trial Registration
ClinicalTrials.gov: NCT04434469; Registered June 16, 2020; https://www.clinicaltrials.gov/ct2/show/NCT04434469.
Coloniality of Waithood: Africa’s Wait for COVID-19 Vaccines amid COVAX and TRIPS
Authors: Hagan Ampson 
Published: January 2023

AbstractAfrican nations have struggled to secure lifesaving COVID-19 vaccines, while rich nations have purchased more than they needed, depleting the global supply. High vaccine prices and intellectual property regulations that block the production of cheaper generics have contributed to a condition of African waithood. Hagan examines this waithood, which characterizes the disjuncture between African countries’ existential and humanitarian need for COVID-19 vaccines and corporations’ quest for profits in the pandemic. African waithood, produced by pharmaceutical companies including Moderna and Pfizer, is a direct product of colonialism. Waithood echoes the ongoing colonial relations between African nations and the corporations that continue to exploit them.
Comparison of theoretical and experimental models for knee flexion/extension using a cable-driven robot
Authors: Gonçalves Rogério S. , Kaufmann Yasmin V. 
Published: January 2023

AbstractTo support and facilitate the rehabilitation of patients with physical limitations and aid the therapist, several robotic structures are being studied. Among the structures, the cable-driven robots stand out. The cable-driven robots are structures actuated by cables and have the advantages of being flexible and reconfigurable for each patient. The objective of this paper is to develop a theoretical model for knee flexion/extension force and moment using a cable-driven robot. The proposed model is necessary for elaborating a referential to which diagnosis can be made and the improvement of the patient evaluated. The presented theoretical model was validated through experiments with twelve sedentary and healthy volunteers. The first procedure tested ten subjects in three thigh angles for knee flexion motion; the second procedure tested two subjects in flexion and extension for the same thigh angle. The results show the validity of the model for 88.58% of the tests in an ANOVA analysis with a 99% confidence interval. The similarity of data for different gender, ages, and intrinsic factors was noted, implying that the model is representative and independent of the subject’s individuality. Differences between flexion and extension values were observed, which need to be studied in the future.
Fate of charge order in overdoped La-based cuprates
Authors: von Arx K. , Wang Qisi , Mustafi S. , Mazzone D. G. , Horio M. , Mukkattukavil D. John , Pomjakushina E. , Pyon S. , Takayama T. , Takagi H. , Kurosawa T. , Momono N. , Oda M. , Brookes N. B. , Betto D. , Zhang W. , Asmara T. C. , Tseng Y. , Schmitt T. , Sassa Y. , Chang J. 
Published: January 2023

AbstractIn high-temperature cuprate superconductors, stripe order refers broadly to a coupled spin and charge modulation with a commensuration of eight and four lattice units, respectively. How this stripe order evolves across optimal doping remains a controversial question. Here we present a systematic resonant inelastic x-ray scattering study of weak charge correlations in La2−xSrxCuO4 and La1.8−xEu0.2SrxCuO4. Ultra high energy resolution experiments demonstrate the importance of the separation of inelastic and elastic scattering processes. Long-range temperature-dependent stripe order is only found below optimal doping. At higher doping, short-range temperature-independent correlations are present up to the highest doping measured. This transformation is distinct from and preempts the pseudogap critical doping. We argue that the doping and temperature-independent short-range correlations originate from unresolved electron–phonon coupling that broadly peaks at the stripe ordering vector. In La2−xSrxCuO4, long-range static stripe order vanishes around optimal doping and we discuss both quantum critical and crossover scenarios.
The ETS transcription factor ETV6 constrains the transcriptional activity of EWS–FLI to promote Ewing sarcoma
Authors: Lu Diana Y. , Ellegast Jana M. , Ross Kenneth N. , Malone Clare F. , Lin Shan , Mabe Nathaniel W. , Dharia Neekesh V. , Meyer Ashleigh , Conway Amy , Su Angela H. , Selich-Anderson Julia , Taslim Cenny , Byrum Andrea K. , Seong Bo Kyung A. , Adane Biniam , Gray Nathanael S. , Rivera Miguel N. , Lessnick Stephen L. , Stegmaier Kimberly 
Published: January 2023

AbstractTranscription factors (TFs) are frequently mutated in cancer. Paediatric cancers exhibit few mutations genome-wide but frequently harbour sentinel mutations that affect TFs, which provides a context to precisely study the transcriptional circuits that support mutant TF-driven oncogenesis. A broadly relevant mechanism that has garnered intense focus involves the ability of mutant TFs to hijack wild-type lineage-specific TFs in self-reinforcing transcriptional circuits. However, it is not known whether this specific type of circuitry is equally crucial in all mutant TF-driven cancers. Here we describe an alternative yet central transcriptional mechanism that promotes Ewing sarcoma, wherein constraint, rather than reinforcement, of the activity of the fusion TF EWS–FLI supports cancer growth. We discover that ETV6 is a crucial TF dependency that is specific to this disease because it, counter-intuitively, represses the transcriptional output of EWS–FLI. This work discovers a previously undescribed transcriptional mechanism that promotes cancer.
Genome-scale metabolic reconstruction of 7,302 human microorganisms for personalized medicine
Authors: Heinken Almut , Hertel Johannes , Acharya Geeta , Ravcheev Dmitry A. , Nyga Malgorzata , Okpala Onyedika Emmanuel , Hogan Marcus , Magnúsdóttir Stefanía , Martinelli Filippo , Nap Bram , Preciat German , Edirisinghe Janaka N. , Henry Christopher S. , Fleming Ronan M. T. , Thiele Ines 
Published: January 2023

AbstractThe human microbiome influences the efficacy and safety of a wide variety of commonly prescribed drugs. Designing precision medicine approaches that incorporate microbial metabolism would require strain- and molecule-resolved, scalable computational modeling. Here, we extend our previous resource of genome-scale metabolic reconstructions of human gut microorganisms with a greatly expanded version. AGORA2 (assembly of gut organisms through reconstruction and analysis, version 2) accounts for 7,302 strains, includes strain-resolved drug degradation and biotransformation capabilities for 98 drugs, and was extensively curated based on comparative genomics and literature searches. The microbial reconstructions performed very well against three independently assembled experimental datasets with an accuracy of 0.72 to 0.84, surpassing other reconstruction resources and predicted known microbial drug transformations with an accuracy of 0.81. We demonstrate that AGORA2 enables personalized, strain-resolved modeling by predicting the drug conversion potential of the gut microbiomes from 616 patients with colorectal cancer and controls, which greatly varied between individuals and correlated with age, sex, body mass index and disease stages. AGORA2 serves as a knowledge base for the human microbiome and paves the way to personalized, predictive analysis of host–microbiome metabolic interactions.
Precision targeting of autoantigen-specific B cells in muscle-specific tyrosine kinase myasthenia gravis with chimeric autoantibody receptor T cells
Authors: Oh Sangwook , Mao Xuming , Manfredo-Vieira Silvio , Lee Jinmin , Patel Darshil , Choi Eun Jung , Alvarado Andrea , Cottman-Thomas Ebony , Maseda Damian , Tsao Patricia Y. , Ellebrecht Christoph T. , Khella Sami L. , Richman David P. , O’Connor Kevin C. , Herzberg Uri , Binder Gwendolyn K. , Milone Michael C. , Basu Samik , Payne Aimee S. 
Published: January 2023

AbstractMuscle-specific tyrosine kinase myasthenia gravis (MuSK MG) is an autoimmune disease that causes life-threatening muscle weakness due to anti-MuSK autoantibodies that disrupt neuromuscular junction signaling. To avoid chronic immunosuppression from current therapies, we engineered T cells to express a MuSK chimeric autoantibody receptor with CD137-CD3ζ signaling domains (MuSK-CAART) for precision targeting of B cells expressing anti-MuSK autoantibodies. MuSK-CAART demonstrated similar efficacy as anti-CD19 chimeric antigen receptor T cells for depletion of anti-MuSK B cells and retained cytolytic activity in the presence of soluble anti-MuSK antibodies. In an experimental autoimmune MG mouse model, MuSK-CAART reduced anti-MuSK IgG without decreasing B cells or total IgG levels, reflecting MuSK-specific B cell depletion. Specific off-target interactions of MuSK-CAART were not identified in vivo, in primary human cell screens or by high-throughput human membrane proteome array. These data contributed to an investigational new drug application and phase 1 clinical study design for MuSK-CAART for the treatment of MuSK autoantibody-positive MG.
Cross-ancestry genome-wide analysis of atrial fibrillation unveils disease biology and enables cardioembolic risk prediction
Authors: Miyazawa Kazuo , Ito Kaoru , Ito Masamichi , Zou Zhaonan , Kubota Masayuki , Nomura Seitaro , Matsunaga Hiroshi , Koyama Satoshi , Ieki Hirotaka , Akiyama Masato , Koike Yoshinao , Kurosawa Ryo , Yoshida Hiroki , Ozaki Kouichi , Onouchi Yoshihiro ,   BioBank Japan Project, Matsuda Koichi , Murakami Yoshinori , Kamatani Yoichiro , Takahashi Atsushi , Matsuda Koichi , Murakami Yoshinori , Aburatani Hiroyuki , Kubo Michiaki , Momozawa Yukihide , Terao Chikashi , Oki Shinya , Akazawa Hiroshi , Kamatani Yoichiro , Komuro Issei 
Published: January 2023

AbstractAtrial fibrillation (AF) is a common cardiac arrhythmia resulting in increased risk of stroke. Despite highly heritable etiology, our understanding of the genetic architecture of AF remains incomplete. Here we performed a genome-wide association study in the Japanese population comprising 9,826 cases among 150,272 individuals and identified East Asian-specific rare variants associated with AF. A cross-ancestry meta-analysis of >1 million individuals, including 77,690 cases, identified 35 new susceptibility loci. Transcriptome-wide association analysis identified IL6R as a putative causal gene, suggesting the involvement of immune responses. Integrative analysis with ChIP-seq data and functional assessment using human induced pluripotent stem cell-derived cardiomyocytes demonstrated ERRg as having a key role in the transcriptional regulation of AF-associated genes. A polygenic risk score derived from the cross-ancestry meta-analysis predicted increased risks of cardiovascular and stroke mortalities and segregated individuals with cardioembolic stroke in undiagnosed AF patients. Our results provide new biological and clinical insights into AF genetics and suggest their potential for clinical applications.