bluuebunny/crossref_metadata_2025_split huggingface dataset:
ILAE Genetic Literacy Series: Self‐limited familial epilepsy syndromes with onset in neonatal age and infancy
Authors: Millevert Charissa , Weckhuysen Sarah ,   for the ILAE Genetics Commission
Published: March 2023

AbstractThe self‐limited (familial) epilepsies with onset in neonates or infants, formerly called benign familial neonatal and/or infantile epilepsies, are autosomal dominant disorders characterized by neonatal‐ or infantile‐onset focal motor seizures and the absence of neurodevelopmental complications. Seizures tend to remit during infancy or early childhood and are therefore called “self‐limited”. A positive family history for epilepsy usually suggests the genetic etiology, but incomplete penetrance and de novo inheritance occur. Here, we review the phenotypic spectrum and the genetic architecture of self‐limited (familial) epilepsies with onset in neonates or infants. Using an illustrative case study, we describe important clues in recognition of these syndromes, diagnostic steps including genetic testing, management, and genetic counseling.
Focal epilepsies: Update on diagnosis and classification
Authors: Nascimento Fábio A. , Friedman Daniel , Peters Jurriaan M. , Bensalem‐Owen Meriem K. , Cendes Fernando , Rampp Stefan , Wirrell Elaine , Blümcke Ingmar , Tatum William , Beniczky Sándor 
Published: March 2023

AbstractCorrectly diagnosing and classifying seizures and epilepsies is paramount to ensure the delivery of optimal care to patients with epilepsy. Focal seizures, defined as those that originate within networks limited to one hemisphere, are primarily subdivided into focal aware, focal impaired awareness, and focal to bilateral tonic–clonic seizures. Focal epilepsies account for most epilepsy cases both in children and adults. In children, focal epilepsies are typically subdivided in three groups: self‐limited focal epilepsy syndromes (e.g., self‐limited epilepsy with centrotemporal spikes), focal epilepsy of unknown cause but which do not meet criteria for a self‐limited focal epilepsy syndrome, and focal epilepsy of known cause (e.g., structural lesions—developmental or acquired). In adults, focal epilepsies are often acquired and may be caused by a structural lesion such as stroke, infection and traumatic brain injury, or brain tumors, vascular malformations, metabolic disorders, autoimmune, and/or genetic causes. In addition to seizure semiology, neuroimaging, neurophysiology, and neuropathology constitute the cornerstones of a diagnostic evaluation. Patients with focal epilepsy who become drug‐resistant should promptly undergo assessment in an epilepsy center. After excluding pseudo‐resistance, these patients should be considered for presurgical evaluation as a means to identify the location and extent of the epileptogenic zone and assess their candidacy for a surgical procedure. The goal of this seminar in epileptology is to summarize clinically relevant information concerning focal epilepsies. This contributes to the ILAE's mission to ensure that worldwide healthcare professionals, patients, and caregivers continue to have access to high‐quality educational resources concerning epilepsy.
Modeling and optimization of hybrid renewable energy with storage system using flamingo swarm intelligence algorithms
Authors: Raghuwanshi Santosh S. , Raghuwanshi Prashant , Masih Animesh , Singh Preeti 
Published: March 2023

AbstractThis paper unveils the simulation and optimum design of five models based on photovoltaic (PV), diesel generator (DG), and battery energy systems for rural area farmhouse load demand (agriculture and household). The choice for designing an optimal energy system is constructed on minimum technical considerations like loss of load probability (LOLP), economic (cost of electricity [COE] with net present cost [NPC]), environmental (CO2aspects) using a novel flamingo swarm intelligence algorithm (FSIA). The optimization results are compared by particle swarm intelligence algorithm, improved particle swarm intelligence algorithm, genetic algorithms, and hybrid optimization of multiple energy resources (HOMER‐Pro). FSIA shows PV/DG/battery energy system to be an optimal system as regards NPC (Rs. 8 056 734), COE (12.14 Rs./kWh), CO2(13 784 kg/y), and LOLP (0.00000501 per year). The saving of the fuel cost and CO2emission from PV/DG/battery to DG only system is 66.10% and 61.26%, respectively.
A dynamic game modeling on air pollution mitigation with regional cooperation and noncooperation
Authors: Yang Tingru , Liao Hua , Du Yunfei 
Published: March 2023

Abstract
Mitigating regional air pollution involves multifaceted trade-offs, including long-term versus short-term development versus emission-reduction among different regions. Considering the heterogeneity of levels of regional economic development and capacity for environmental governance as well as the spatial spillover effect of pollution, the game theory method can explore each region's dynamic emission-reduction path. In this article, the dynamic game mechanism (Regional Environment Economy Game Modeling model) is incorporated into the environment economy system to solve the Nash equilibrium under dynamic conditions and explore the game strategies of each region. Taking air pollution mitigation in North China as an example, this article compares the emission-reduction effect and social welfare under regional cooperative and noncooperative game scenarios and clarifies the abatement-sharing mechanism between provinces. The results show that a noncooperative policy is strictly inferior to a cooperative policy for achieving given emission-reduction goals and maximizing social welfare. Our findings offer evidence for strengthening regional cooperation in reducing carbon emissions and provide policy recommendations for synergistic pollution abatement and joint regional pollution mitigation. Integr Environ Assess Manag 2023;19:1555–1569. © 2023 SETAC
Have You Heard of Bonnie Bassler? A Historical Perspective on a Remarkable Career
Authors: Fuqua Clay 
Published: March 2023

AbstractThe area of chemical communication in bacteria has grown explosively since the end of the 20th century. Among a number of key individuals and seminal findings that broke open this area of microbiology, the contributions of Bonnie Bassler and her colleagues are immense and multi‐layered. In this short and informal review, I provide perspective on my own entry into this research field, my introduction to Dr. Bassler and her early findings, followed by the founding of the Bassler lab and the flood of brilliant experimentation and public outreach that has done so much to propel the field of bacterial chemical communication.
Re‐Imagining Drug Discovery using Mass Spectrometry
Authors: Cooks R. Graham , Feng Yunfei , Huang Kai‐Hung , Morato Nicolás M. , Qiu Lingqi 
Published: March 2023

AbstractIt is argued that each of the three key steps in drug discovery, (i) reaction screening to find successful routes to desired drug candidates, (ii) scale up of the synthesis to produce amounts adequate for testing, and (iii) bioactivity assessment of the candidate compounds, can all be performed using mass spectrometry (MS) in a sequential fashion. The particular ionization method of choice, desorption electrospray ionization (DESI), is both an analytical technique and a procedure for small‐scale synthesis. It is also highly compatible with automation, providing for high throughput in both synthesis and analysis. Moreover, because accelerated reactions take place in the secondary DESI microdroplets generated from individual reaction mixtures, this allows either online analysis by MS or collection of the synthetic products by droplet deposition. DESI also has the unique advantage, amongst spray‐based MS ionization methods, that complex buffered biological solutions can be analyzed directly, without concern for capillary blockage. Here, all these capabilities are illustrated, the unique chemistry at droplet interfaces is presented, and the possible future implementation of DESI‐MS based drug discovery is discussed.
Interaction of the coupled effects of irrigation mode and nitrogen fertilizer timing on rice yield in different regions
Authors: Su Qingwang , Cang Baifeng , Ullah Raza , Song Ze , Li Yunzhe , Cui Jingjing , Wei Xiaoshuang , Yang Meiying , Yang Xue , Wu Zhihai 
Published: March 2023

AbstractThe production efficiency of water and nitrogen is affected by irrigation and the nitrogen rate. However, it is unclear whether there is a coupling effect of irrigation mode and the timing of nitrogen fertilizer application on rice. Therefore, a two‐year field experiment was conducted at two sites with varying cumulative temperatures from 2018 to 2019. The effects of irrigation mode and nitrogen fertilization timing on rice yield and related physiological parameters were examined in different regions. The results showed that sites with different average temperatures had different coupling effects of water and nitrogen on crop growth. The impact of irrigation mode on yield was greater than that of nitrogen fertilizer timing at the site with a 2800 °C annual cumulative temperature (Wanchang). Alternate wetting and drying irrigation increased yield, water production efficiency and nitrogen production efficiency by 8%–10%, 31%–37% and 8%–10%, respectively. In the site with a 2500 °C annual cumulative temperature (Longjing), the coupling effect of irrigation method and nitrogen fertilization timing was significant, and continuously flooded irrigation combined with nitrogen fertilizer (40%:30%:20%:10%) improved rice yield and production efficiency by delaying senescence of leaves and increasing dry matter translocation. The results indicate that combining temperature to explore the optimal coupling mode of irrigation and nitrogen is a promising cropping technique to improve crop productivity and production efficiency in northeastern China.
Decline in intravenous immunoglobulin titer against influenza virus A/H2N2 derived from donors in Japan
Authors: Yunoki Mikihiro , Kubota‐Koketsu Ritsuko , Shioda Tatsuo 
Published: March 2023

AbstractHuman influenza A/H2N2 can induce a pandemic in the future. This study evaluated the hemagglutination inhibition and neutralizing titers of intravenous immunoglobulin against A/H2N2 viruses, indicating the status of the donor population. In this study, the antibody titers decreased during the study period—2012–2021—suggesting a reduction in the immunity of the studied population.
Design of microaerobically inducible miniR1 plasmids
Authors: Islas Fabiola , Sabido Andrea , Sigala Juan‐Carlos , Lara Alvaro R. 
Published: March 2023

Impact statementPlasmid DNA manufacture is an essential step to produce gene therapy agents and next‐generation vaccines. However, little attention has been paid toward developing alternative replicons that can be coupled with large‐scale production conditions. Our results demonstrate that the miniR1 replicon can be efficiently induced by oxygen limitation when a copy of the regulatory protein RepA under control of a microaerobic promoter is used. The results are potentially attractive for industrial applications.
Bile Acid Alterations Characterize the Early Onset and Progression of Nonalcoholic Fatty Liver Disease in Young Mice Fed with High Fat and Fructose Diet
Authors: Xiang Wenqing , Liu Ana , Xu Cuifang , Zhang Danni , Li Wei , Ni Yan 
Published: March 2023

ScopeBile acids (BAs) are closely associated with obesity and non‐alcoholic fatty liver disease (NAFLD). How BAs change within the enterohepatic circulation during the onset and progression of NAFLD as biomarkers deserves to be explored.Methods and ResultsFour‐week‐old young mice were fed with high‐fat diet plus 4% v/w fructose drinking water (HFF) or normal diet with tap water (ND) for 4 and 12 weeks. In comparison, eight‐week‐old adult mice were fed with HFF or ND for 12 weeks. BAs were measured in six different anatomical sites to evaluate the systematic changes of BAs within the enterohepatic circulation. The dysregulated BA metabolism had occurred in HFF after 4‐week intervention, represented by increased primary BAs and decreased hyocholic acid (HCA) species. After 12 weeks, the impact was more significant with increased secondary BA synthesis and excretion, particularly for lithocholic acid (LCA) species. More interestingly, the BA changes were more significant in younger mice in response to 12‐week diet intervention.ConclusionsThe enterohepatic circulation of BAs changed with the development of NAFLD, and the younger mice were more susceptible to the unhealthy diet. HCA and LCA species may be potential biomarkers for predicting the development of NAFLD.
Realizing efficient asymmetric transmission using optical activity of ultrathin chiral metasurfaces for K‐band applications
Authors: Bibi Aisha , Ismail Khan M. , Hu Bin , Khan Imdad 
Published: March 2023

AbstractAn elliptical chiral split‐ring‐resonator‐based bilayer thin metasurface is introduced in this paper. The proposed metasurface realizes strong electromagnetic (EM) activity with asymmetric transmission in the K‐band of the microwave regime. The efficiency is more than 80% over a range of frequencies from 18.6 to 20.8 GHz. Angular stability up to 60° makes the structure robust for practical applications. The structure also exhibits a negative refractive index for circularly polarized wave due to the strong chirality factor. Polarization azimuth rotation angle of 90° and ellipticity of 0° reveal the pure EM/optical activity. Furthermore, the simulation and measured results also affirmed orthogonal pure linear polarization transformation. The proposed chiral metasurface finds applications in radar and satellite belonging to K‐band.
Extraction of the optical properties of waveguides through the characterization of silicon‐on‐insulator integrated circuits
Authors: Ershov Alexander A. , Eremeev Andrey I. , Nikitin Andrey A. , Ustinov Alexey B. 
Published: March 2023

AbstractIn the present work, a method to determine the optical waveguide properties of silicon‐on‐insulator (SOI) integrated circuits has been developed. According to the explicit relations between transfer functions of a microring resonator and the waveguide properties the inner optical parameters could be extracted. An increase in accuracy can be achieved by measuring the transfer functions of additional elements, such as a straight waveguide and a directional coupler. It is shown that the developed method allows one to determine the coupling coefficient, damping decrement, Bragg grating coupler efficiency, and waveguide dispersion with high accuracy. The obtained optical waveguide properties are used for modeling the transmission of a Mach–Zehnder interferometer which is used as a control element. The modeling results demonstrate a good agreement with the experimental characteristics. The developed method paves the way to local characterization of large‐scale SOI integrated circuits by using the aforementioned structures as reference elements.
Automatic segmentation of neurovascular bundle on mri using deep learning based topological modulated network
Authors: Lei Yang , Wang Tonghe , Roper Justin , Tian Sibo , Patel Pretesh , Bradley Jeffrey D. , Jani Ashesh B. , Liu Tian , Yang Xiaofeng 
Published: March 2023

AbstractPurposeRadiation damage on neurovascular bundles (NVBs) may be the cause of sexual dysfunction after radiotherapy for prostate cancer. However, it is challenging to delineate NVBs as organ‐at‐risks from planning CTs during radiotherapy. Recently, the integration of MR into radiotherapy made NVBs contour delineating possible. In this study, we aim to develop an MRI‐based deep learning method for automatic NVB segmentation.MethodsThe proposed method, named topological modulated network, consists of three subnetworks, that is, a focal modulation, a hierarchical block and a topological fully convolutional network (FCN). The focal modulation is used to derive the location and bounds of left and right NVBs’, namely the candidate volume‐of‐interests (VOIs). The hierarchical block aims to highlight the NVB boundaries information on derived feature map. The topological FCN then segments the NVBs inside the VOIs by considering the topological consistency nature of the vascular delineating. Based on the location information of candidate VOIs, the segmentations of NVBs can then be brought back to the input MRI's coordinate system.ResultsA five‐fold cross‐validation study was performed on 60 patient cases to evaluate the performance of the proposed method. The segmented results were compared with manual contours. The Dice similarity coefficient (DSC) and 95th percentile Hausdorff distance (HD95) are (left NVB) 0.81 ± 0.10, 1.49 ± 0.88 mm, and (right NVB) 0.80 ± 0.15, 1.54 ± 1.22 mm, respectively.ConclusionWe proposed a novel deep learning‐based segmentation method for NVBs on pelvic MR images. The good segmentation agreement of our method with the manually drawn ground truth contours supports the feasibility of the proposed method, which can be potentially used to spare NVBs during proton and photon radiotherapy and thereby improve the quality of life for prostate cancer patients.
Effect of particle shape and bedding angle on suffusion in gap‐graded granular soils by coupled CFD‐DEM method
Authors: Zhou Chuang , Qian Jian‐Gu , Yin Zhen‐Yu , Liu Ya‐Jing , Du Zi‐Bo 
Published: March 2023

AbstractThe natural deposition of soils results in significant fabric anisotropy, and its influence on suffusion remains unclear. In this study, a series of gap‐graded soil samples with different particle shapes and bedding angles are generated and implemented into the coupled computational fluid dynamics‐discrete element method (CFD‐DEM) simulations to investigate the migration of fine particles within the coarse grain matrix. Macroscopic results, including mass loss, void ratio variation, and soil deformation, as well as microscopic particle trajectory, force chain network, and contact orientation are analyzed. In addition, drained triaxial tests on samples before and after erosion are carried out. All results turn out that the greater the bedding angle, the more severe the loss of fines and the more significant the soil deformation. Three different migration characteristics can be identified according to soil anisotropy degree, that is, when the bedding angle is 0°, the migration of fine particles remains relatively stable; when the bedding angle is 30° and 60°, the particle migration shows a gradual change throughout the erosion; when the bedding angle is 90°, the fine particles migrate significantly in the very early stages of suffusion. Besides, the aspect ratio (AR) of the particle is found to be beneficial for both erosion resistance and soil strength.
Trends in clomiphene citrate and gonadotropins use in women with infertility between 2010 and 2017: A population‐based study in France
Authors: Bourrion Bastien , Panjo Henri , François Mathilde , Pelletier‐Fleury Nathalie 
Published: March 2023

AbstractPurposeTo describe temporal trends and assess factors associated with changes in the prescription of clomiphene citrate and gonadotropins between 2010 and 2017 in women with infertility aged 18–50 from metropolitan France.Methods6321 prevalent women from a representative sample of the national medico‐administrative database were identified. We performed a Cochran‐Armitage trend test and calculated the rate ratios. A Poisson regression was used to derive the incidence rate ratios, for each treatment class.ResultsThe prevalence rate and incidence rate of clomiphene citrate use significantly decreased by 20% (RR 0.80: 95% CI 0.71–0.90) and 23% (RR 0.77: 95% CI 0.66–0.89), respectively. Its initiation was higher in all age groups compared to the reference (18–24 years), with a downward gradient. It was also higher when the density of gynaecologists was higher and in disadvantaged areas. The prevalence rate and incidence rate of gonadotropin use increased by 11% (RR 1.11: 95% CI 1.01–1.22) and 33% (RR 1.33: 95% CI 1.14–1.55) respectively. Gonadotropin initiation was highest in the 31–35 age group, but it was also higher in the 25–30 and 36–40 age groups at a similar level (reference 18–24 years). Its initiation was higher when the density of gynaecologists was higher, but not associated with social deprivation.ConclusionOur results showed an increase in gonadotropin use for infertility treatment in France during the 2010–2017 period and a decrease in clomiphene citrate use. Further work should be undertaken to analyse the use of these drugs in relation to women's care pathways.
Accuracy of identifying pediatric acute bacterial sinusitis diagnoses in outpatient claims data
Authors: Savage Timothy J. , Wardell Hanna , Huybrechts Krista F. 
Published: March 2023

AbstractPurposeAcute bacterial sinusitis is among the most frequent outpatient infections in children and adolescents and is well suited to study in large healthcare utilization databases, but the validity of International Classification of Diseases, 10th Revision (ICD‐10) codes together with antibiotic prescriptions to identify cases of acute bacterial sinusitis has not been established. We aimed to evaluate the validity of ICD‐10 codes combined with antibiotic prescriptions to identify new diagnoses of acute bacterial sinusitis among pediatric patients evaluated in the outpatient setting.MethodsChildren and adolescents aged 17 years and younger with an outpatient diagnosis of acute sinusitis along with an antibiotic prescription from an ambulatory facility affiliated with the Mass General Brigham health system were identified via a clinical data warehouse. Patients were stratified by age (0–5 years, 6–11 years, and 12–17 years), and 50 cases per age group were randomly sampled. Medical records were independently reviewed by two pediatric infectious diseases physicians to assess for the documentation of a clinician‐defined diagnosis of acute bacterial sinusitis. Positive predictive values (PPVs) and 95% confidence intervals (CIs) were calculated.ResultsA total of 150 patients were included in the final cohort. Frontal, maxillary, and “unspecified” sinuses accounted for 88% of the diagnoses. The positive predictive value of the algorithm to identify clinician‐defined diagnoses of acute bacterial sinusitis was 92% (95% CI 87%, 95%). The PPVs were consistent across age strata.ConclusionsICD‐10 codes for acute sinusitis, when paired with a same‐day antibiotic prescription, have a high positive predictive value among a cohort of pediatric patients, suggesting that they can be used to study new acute bacterial sinusitis diagnoses with claims.