bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of the effectiveness of topical oily solution containing frankincense extract in the treatment of knee osteoarthritis: a randomized, double-blind, placebo-controlled clinical trial
Authors: Mohsenzadeh Afsaneh , Karimifar Mansoor , Soltani Rasool , Hajhashemi Valiollah 
Published: March 2023

Abstract
Objective
Pharmacological treatments of osteoarthritis (OA) have several side effects. Boswellia serrata resin (frankincense) is rich in boswellic acids that have antioxidant and anti-inflammatory effects; though, their oral bioavailability is low. The aim of this study was evaluation of the clinical effectiveness of frankincense extract in the treatment of knee OA. In a randomized double-blind placebo-controlled clinical trial, eligible patients with knee OA were randomly divided into two groups of drug (33 patients) and control (37 patients), to use oily solution of frankincense extract or placebo, respectively, on the involved knee three times daily for four weeks. WOMAC (Western Ontario and McMaster Universities Osteoarthritis Index), VAS (visual analogue scale; for pain severity), and PGA (patient global assessment) scores were determined before and after intervention.

Results
For all evaluated outcome variables, there was a significant decrease from baseline in both groups (P < 0.001 for all). Furthermore, the end-of-intervention values for all parameters were significantly lower in drug group than placebo group (P < 0.001 for all), showing more effectiveness of drug compared to placebo.

Conclusion
Topical oily solution containing enriched extract of boswellic acids could decrease pain severity and improve the function in patients with knee OA.
Trial Registration Trial registration number: IRCT20150721023282N14. Trial registration date: September 20, 2020. The study was retrospectively registered in Iranian Registry of Clinical Trials (IRCT).
Can Alhaji maurorum as a halophyte plant be ensiled with molasses and Saccharomyces cerevisiae well?
Authors: Kazemi Mohsen , Valizadeh Reza 
Published: March 2023

AbstractAlhagi maurorum(Caspian Manna, AM) is a species of legume found commonly in the semi-arid region of the world. Nutritional aspects of silage prepared from AM have not been scientifically investigated so far, therefore, in this study, chemical-mineral composition, gas production parameters, ruminal fermentation parameters, buffering capacity, and silage characteristics of AM were investigated by standard laboratory methods. Fresh AM was ensiled in the mini-silos (3.5 kg) and treated with (1) no additive (control), (2) 5% molasses, (3) 10% molasses, (4) 1 × 104CFU ofSaccharomyces cerevisiae[SC]/g of fresh silage, (5) 1 × 104CFU of SC/g of fresh silage + 5% molasses, (6) 1 × 104CFU of SC/g of fresh silage + 10% molasses, (7) 1 × 108CFU of SC/g of fresh silage, (8) 1 × 108CFU of SC/g of fresh silage + 5% molasses, and (9) 1 × 108CFU of SC/g of fresh silage + 10% molasses for 60 days. The lowest concentrations of NDF and ADF were related to treatments no. 6 and 5, respectively (p < 0.0001). The ash content as well as sodium, calcium, potassium, phosphorus and magnesium were highest in treatment no 2. Silages containing 10% molasses (no. 3) had the highest and lowest lactic (p < 0.0001) and butyric (p < 0.0001) acids, respectively. The highest amount of potential gas production was observed in treatments no. 5 and 6, respectively (p < 0.0001). Total yeast was decreased with increasing molasses in the silages (p < 0.0001). Acid-base buffering capacity was also highest in treatments no. 6 and 5, respectively (p = 0.0003). In general, due to the fibrous nature of AM, it is recommended to add molasses at levels of 5 or 10% when ensiling. The silages containing SC at a lower level (1 × 104CFU) along with higher levels of molasses (10% of DM) had better ruminal digestion-fermentation characteristics compared to other silages. Also, the addition of molasses improved the internal fermentation characteristics of AM in the silo.
The impact of an online inquiry-based learning environment addressing misconceptions on students' performance
Authors: Siantuba Jackson , Nkhata Leonard , de Jong Ton 
Published: March 2023

AbstractThis study sought to develop and evaluate an online module based on inquiry learning with digital laboratories, which was intended to address students’ misconceptions in a science domain. In a quasi-experimental design, 171 first-year students in a higher education introductory physics course on circular motion were as their existing groups assigned to an experimental (n = 100) or a control (n = 71) condition. The experimental condition was developed by arranging online inquiry activities that would encourage students to probe five identified misconceptions. The control condition required students to engage in online inquiry following the traditional syllabus outline. Students in both conditions used the same type of digital laboratory setup. The participants learned about the topic of circular motion and their knowledge was assessed. Results of the knowledge test revealed that the experimental condition geared towards addressing students’ misconceptions facilitated conceptual change more than the control condition.
An experimental and numerical investigation of energy absorption of sportswear in seam area
Authors: Sajjadi Ali , Hosseini Seyed Abdolkarim , Ajeli Saeed , Mashayekhi Mohammad 
Published: March 2023

AbstractThis study aims to investigate the energy absorption of seam areas in sportswear. Weft knitted fabrics with two structures of plain and rib were fabricated by polyester/Lycra and viscose/ Lycra yarns. Fabrics were stitched in two stitch classes. Moreover, two types of seams were considered. A pull-out test was carried out on all samples to determine the energy absorption values. Furthermore, a finite element model was applied to predict the energy absorption of each structure. The unit cell of each sample was created in ABAQUS software and the tensile load was applied to the stitch yarn. The unit cells of the fabric and the stitched section were modeled in the meso-scale and then elastic and viscoelastic properties of the yarns were assigned to the model. The energy absorption of the sample with rib pattern, lapped seam, and 607 stitch class was more than other samples. Also, the numerical and experimental results showed a high correlation with each other in samples with 304 stitch class and flat seam type.
Food insecurity among families with infants born during the COVID-19 pandemic in Fortaleza, Northeast Brazil
Authors: Farías-Antúnez Simone , Machado Márcia Maria Tavares , Correia Luciano Lima , Rocha Hermano Alexandre Lima , Araújo David Augusto Batista Sá , Pinheiro Maria Suelly Nogueira , Aquino Camila Machado , Penna Ana Luiza , Castro Marcia C. 
Published: March 2023

Abstract
Purpose
To assess the prevalence of food insecurity (FI) among families with infants born during the COVID-19 pandemic and its associated factors in Fortaleza, the fifth largest city in Brazil.

Methods
Data from two survey rounds of the Iracema-COVID cohort study collected at 12 (n = 325) and 18 months (n = 331) after birth. FI was measured using the Brazilian Household Food Insecurity Scale. FI levels were described according to potential predictors. Crude and adjusted logistic regressions with robust variance were used to assess factors associated with FI.

Results
In the 12- and 18-month follow-ups interviews, there was a 66.5% and 57.1% prevalence of FI, respectively. Over the study period, 3.5% of the families persisted in severe FI and 27.4% in mild/moderate FI. Households headed by mothers, with more children, low education and income, sustained maternal common mental disorders, and that were beneficiaries of cash transfer programs were the most affected by persistent FI.

Conclusions
Although the prevalence of FI decreased in our sample, almost 60% of families in Fortaleza still have no regular access to enough and/or nutritionally appropriate food. We have identified the groups at higher FI risk, which can guide governmental policies.
A scoping review of the impact of heat stress on the organs of the Japanese quail (Coturnix japonica)
Authors: Abdulkadir Abdurrahman , Reddy Deran 
Published: March 2023

Abstract
Background
Heat stress negatively affects poultry welfare, including the Japanese quail, especially in sub-Saharan African countries. The quail is vital to research and protein food security, which are affected by global warming. This study identified and reviewed the literature on the impact of heat stress on the Japanese quail organs to provide context for the problem and ways to mitigate it.

Main body
Eligible studies for this scoping review must be primarily animal-based experiments that include Japanese quail exposure to acute or chronic heat stress. Systematic reviews, theses and dissertations that meet these criteria were also eligible for use in this review. Reports that involved other types of quail species, eggs and or cell lines were not eligible and were excluded. The databases that were searched include MEDLINE (via PubMed), SCOPUS, CAB Abstracts (via CAB Direct) and Web of Sciences (All databases). A total of 4598 records were identified. After removing 105 duplicates, 4461 and 9 were excluded during the level 1 and 2 screening, respectively. Finally, 24 papers were included for data extraction. All eligible studies were primary animal experiments, and the average heat stress temperature level was 35.3 °C. Morphological findings of this scoping review include macrovesicular steatosis in the liver, necrosis of kidney tubular cells, dead and abnormal sperm cells in the testis, lung congestion, and neuronal degeneration resulting from heat stress exposure.

Conclusions
Heat stress negatively impacts the organs of the Japanese quail, causing cell death in the liver, brain and testis, which will affect the production and survival of the Japanese quail. In addition, some cost-effective dietary strategies tested in mitigating heat stress were recommended.
QUALITY ASSESSMENT OF NATURAL WATERS IN TERRITORIES IMPACTED BY THE OIL AND GAS INDUSTRY
Authors: Ivanov Vyacheslav B. , Komissarova Tat’yana S. , Shcherbakov Arkadiy V. , Yаkubec Ruslan R. 
Published: March 2023

Background. The study area is one of the main regions of the Russian Federation, where intensive development and production of hydrocarbons are carried out. They are directly accompanied by a very significant anthropogenic impact on the environment in general, and on water bodies in particular. The article, based on the analysis of chemicals concentration in surface waters, bottom sediments and coastland soil, gives an assessment of water bodies quality on the territory of the oil and gas industry.
Purpose. The purpose of the study is to assess the quality of surface waters, benthic ecosystem and coastland soil of water bodies on the territory of oil and gas fields of the Middle Ob region.
Materials and methods. On the basis of chemical analysis, concentrations of chemical elements were determined in samples of surface waters, bottom sediments and coastland soil of water bodies. Based on the concentration of chemical elements in a particular environment, the index of surface water pollution was determined by the calculation method, the state of the coastland soil and the benthic ecosystem was assessed.
Results. The calculation of the integral assessment of water quality shows that the studied water bodies range from moderately polluted to extremely polluted. Quality deterioration of the benthic ecosystem is observed in most of the studied water bodies.
Conclusion. The study of the environmental condition of water bodies by the quality of surface waters, bottom sediments and the coastland soil shows the negative anthropogenic impact of the oil and gas industry on the studied water bodies.
DECREASE IN THE CONTENT OF REACTIVE OXYGEN SPECIES DURING INACTIVATION OF THE RESPIRATORY COMPLEX I IN ARABIDOPSIS CELLS
Authors: Tarasenko Vladislav I. , Garnik Elena Y. , Shmakov Vladimir N. , Konstantinov Yuri M. 
Published: March 2023

Background. The mitochondrial electron transport chain, in particular the respiratory complex I, is one of the main sources of reactive oxygen species (ROS) in living cells. Suppression of the complex I activity in human cells through chemical inhibition or mutations that disrupt the functionality of this complex leads to a significant increase in the content of ROS. The complex I mutants are also known for plants; however, it is still not clear whether the suppression of the activity of this complex leads to an increase in the level of ROS and the development of oxidative stress.
Purpose. To study the level of superoxide, hydrogen peroxide and sensitivity to prooxidants in Arabidopsis ndufs4 cells with complex I inactivated by insertional mutagenesis.
Materials and methods. A suspension culture of wild-type Arabidopsis cells and a line with knockout the NDUFS4 complex I subunit was used. The level of hydrogen peroxide in the cells was determined using dichlorofluorescein. The superoxide content was estimated by cell staining in the presence of nitroblue tetrazolium.
Results. It has been shown that inactivation of the NADH-dehydrogenase complex in Arabidopsis cells due to the absence of one of its subunits leads to a decrease in the content of superoxide and hydrogen peroxide. It was also shown that the level of ROS in cells treated with the menadione and hydrogen peroxide increased several times in wild-type cells, but remained almost unchanged in ndufs4 cells.
Conclusion. Suppression of the activity of the NADH dehydrogenase complex in plant cells, but not in animal cells, leads to a decrease in the content of both hydrogen peroxide and superoxide. Cells of ndufs4 line have an increased ability to detoxify ROS, possibly associated with the constant mobilization of antioxidant defense systems.
PREVALENCE OF ALEXITHYMIA AMONG ADOLESCENTS IN THE CENTRAL AND SOUTHERN REGIONS OF SIBERIA
Authors: Zaitseva Zhanna G. , Kolodyazhnaya Tatyana A. , Zaitseva Olga I. , Ignatova Irina A. 
Published: March 2023

Aim. To study the prevalence of alexithymia among adolescents in the central (Krasnoyarsk city/Caucasians) and southern (Abakan, the Republic of Khakassia, Caucasians/Khakasses) regions of Siberia, taking into account ethnicity and gender differences.
Materials and methods. Interviewing schoolchildren of various ethnic backgrounds aged 15-18 years is carried out using the Toronto Alexithymic Scale (TAS-26).
Results. Mong Caucasian adolescents from different regions of residence (Krasnoyarsk and Abakan, the Republic of Khakassia), the prevalence rates of alexithymia were comparable (30,0% and 34,2%). For Khakas teenagers in Abakan, the Republic of Khakassia, this indicator (56.3%) was statistically significantly higher (p<0,001) in comparison with Caucasian teenagers, which we regard as a manifestation of the ethno-specific component of the Khakas personality in adolescence. Gender differences were established, manifested by a small number of non-alexithymic Khakass girls (6,8%) in comparison with Khakass boys (p=0,0360).
Conclusion. Identification among practically healthy adolescents of subjects with signs of alexithymia is necessary for the timely implementation of preventive measures, and corrective measures should be targeted at girls and boys. Rational implementation of preventive measures and dynamic monitoring of alexithymic adolescents will reduce the risk of psychosomatic disorders and the frequency of adverse outcomes.
COMPARATIVE ANALYSIS OF AVAILABLE METHODS OF CLEANING AND DISINFECTION OF REMOVABLE PLATE PROSTHESES FOR THE ELDERLY AND SENILE
Authors: Chizhov Yuri V. , Radkevich Andrey A. , Mitrofanov Pavel V. , Kazantseva Tamara V. , Babich Marina N. , Sokolovich Vladimir V. 
Published: March 2023

Objective. To analyze three methods of cleaning and disinfection of removable plate prostheses (protected by patents) available for elderly and senile persons with psychoneurological diseases living in boarding schools.
Materials and methods. Technologies of application of the following methods of cleaning and disinfection of removable plate prostheses are described:
1) using an ultrasonic dispersant UZDN-A with a complex of individual reagents;
2) using the ozonizer-sterilizer « Ozon-stom»;
3) with the help of an ultrasonic washing machine «Retona» and an original complex of domestic reagents.
Results. Their positive and negative aspects are revealed; it is established: that each method carried out according to the instructions gives 100% disinfection of removable dentures; the most rational method of ultrasonic treatment with the use of a washing machine of the «Retona» type; for the removal of old and dense deposits of plaque, the method with the use of a dispersant UZDN-A is preferable; the method of ozonation for the elderly and senile people suffering from neuropsychiatric diseases can only be used with the participation of medical staff.
Conclusion. The considered methods of cleaning and disinfection of removable plate prostheses can be applied to a greater or lesser extent for the elderly and senile in residential homes of psycho-neurological profile, with complete success can be applied to this category of persons living in a family or in residential homes for the elderly without diseases of this profile. According to the volume of positive aspects, the method of cleaning removable plate prostheses using a washing machine of the “Retona” type and the original complex of domestic reagents is most preferable.
STUDY OF THE EFFECT OF NEW 6-R-3,5-DINITRO-1,2,3,4-TETRAHYDROPYRIDINES ON THE ACCUMULATION OF PHOTOSYNTHETIC PIGMENTS AND ASCORBIC ACID IN PLANT TISSUES
Authors: Ivanova Evgeniya V. , Zhukov Nikolay N. , Surova Irina I. , Nikishina Maria B. , Mukhtorov Loik G. , Atroshchenko Yuri M. 
Published: March 2023

Background. The problem of finding new effective plant protection products remains an urgent task of modern agrochemistry. It is known that tetrahydropyridine derivatives exhibit a broad spectrum of biological activity, including fungicidal activity. However, compounds with potential biological activity can also be highly toxic to humans, cultivated crops, and the environment as a whole, so it is necessary to study their environmental safety. The content of photosynthetic pigments and ascorbic acid are one of the most important biochemical indicators of plant response to environmental stress factors, therefore, determining their amount helps to assessthe physiological state of plants and analyze the toxicity of the synthesized compounds.
Purpose. To study the effect of new 6-R-3,5-dinitro-1,2,3,4-tetrahydropyridines on the content of photosynthetic pigments and ascorbic acid in plant tissues in order to assess the safety of their use as potential plant protection products.
Materials and methods. The test compounds were obtained by the previously developed method for the selective reduction of 2-R-3,5-dinitropyridines. Winter wheat seeds of the Moskovskaya 39 variety were germinated in Petri dishes using solutions of the synthesized substances. Seeds germinated in water were used as controls. On the ninth day, the content of various groups of photosynthetic pigments (chlorophylls a, b, carotenoids), as well as ascorbic acid in plant tissues was determined. All experiments were carried out in triplicate. In addition, the analytes were tested for toxicity using the GUSAR Environmental Toxicity software.
Results. The effect of new derivatives of tetrahydropyridine on the accumulation of photosynthetic pigments and ascorbic acid in plant tissues of winter wheat was studied. It was shown that the studied compounds do not have a significant toxic effect on plants.
Conclusion. As a result of studying the effect of new 6-R-3,5-dinitro-1,2,3,4-tetrahydropyridines on the content of photosynthetic pigments and ascorbic acid, as well as in silico computer prediction in GUSAR Environmental Toxicity, it was found that, in general, the studied compounds are relatively safe and, therefore, promising for further testing as biologically active plant protection products.
AGRICULTURAL FINANCING AS THE BASIS FOR FOOD SECURITY IN KAZAKHSTAN UNDER EAEU CONDITIONS
Authors: Alibayev Yerlan A. , Onuchko Marina Yu. 
Published: March 2023

With Kazakhstan’s accession to the Eurasian Economic Union, the government needed to change the instruments to support agriculture and the agro-industrial complex as a whole. As it is on its success that the provision and condition of food security of the country directly depends. Food security is very urgent, especially during the current financial crisis.
To date, the instability of agriculture in Kazakhstan is the main reason for the low level of food security in the country. One of the strategic tasks for Kazakhstan is to ensure food security. There is a lack of scientific research aimed at financing and state support of agriculture as an important prerequisite for ensuring food security in Kazakhstan under the conditions of the Eurasian Economic Union, which determines the purpose of our study.
The following research methods were used in the work: economic and statistical; economic and mathematical methods, including methods of statistical analysis. We use correlation and regression analysis to study the relationship between public financing of the agro-industrial complex and food security. By this we not only analyze the current situation, but also make it possible to implement a medium-term forecast.
The result of the study is a structural analysis of the financing of the agro-industrial complex, which shows that the bulk of the financing is carried out by own funds, and the amount of public investment is less than own resources. Based on the study, the dependence of agriculture in Kazakhstan under the EAEU conditions on state funding and support has been revealed. The main ways and solutions to ensure food security of Kazakhstan in the conditions of the Eurasian Economic Union have been proposed.
Conclusions. Ensuring food security of the population is an integral part of economic, political and national security of the country. In this context, the agro-industrial complex is the main key factor and epicentre of food security of the country, and without state financial support for agriculture, food security of Kazakhstan is and will be under threat. Only by solving this urgent problem can Kazakhstan lead among the member countries of the Eurasian Economic Union. Therefore, in order to ensure food security, measures that need to be taken to develop a food security policy have been proposed. In addition, proposals have been made to regulate and control food security in Kazakhstan.