bluuebunny/crossref_metadata_2025_split huggingface dataset:
Global trends and frontiers in research on exercise training for heart failure: a bibliometric analysis from 2002 to 2022
Authors: Yang Zhen , Zhong Zi-Yi , Zhao Cong-Na , Yin Ming-Yue , Wang Jia-Hui , Wei Jing , Wen Zhi-Shen , Qi Ming 
Published: June 2023

BackgroundHeart failure is a common cardiovascular disease that imposes a heavy clinical and economic burden worldwide. Previous research and guidelines have supported exercise training as a safe, effective, and cost-efficient treatment to intervene in heart failure. The aim of this study was to analyze the global published literature in the field of exercise training for heart failure from 2002 to 2022, and to identify hot spots and frontiers within this research field.MethodsBibliometric information on literature on the topic of exercise training for heart failure published between 2002 and 2022 was searched and collected in the Web of Science Core Collection. CiteSpace 6.1.R6 (Basic) and VOSviewer (1.6.18) were applied to perform bibliometric and knowledge mapping visualization analyses.ResultsA total of 2017 documents were retrieved, with an upward-stable trend in the field of exercise training for heart failure. The US authors were in the first place with 667 documents (33.07%), followed by Brazilian authors (248, 12.30%) and Italian authors (182, 9.02%). The Universidade de São Paulo in Brazil was the institution with the highest number of publications (130, 6.45%). The top 5 active authors were all from the USA, with Christopher Michael O'Connor and William Erle Kraus publishing the most documents (51, 2.53%). The International Journal of Cardiology (83, 4.12%) and the Journal of Applied Physiology (78, 3.87%) were the two most popular journals, while Cardiac Cardiovascular Systems (983, 48.74%) and Physiology (299, 14.82%) were the two most popular categories. Based on the results of keyword co-occurrence network and co-cited reference network, the hot spots and frontiers of research in the field of exercise training for heart failure were high-intensity interval training, behaviour therapy, heart failure with preserved ejection fraction, and systematic reviews.ConclusionThe field of exercise training for heart failure has experienced two decades of steady and rapid development, and the findings of this bibliometric analysis provide ideas and references for relevant stakeholders such as subsequent researchers for further exploration.
Comparing the effectiveness of long-term use of daily and weekly glucagon-like peptide-1 receptor agonists treatments in patients with nonalcoholic fatty liver disease and type 2 diabetes mellitus: a network meta-analysis
Authors: Yuan Xia , Gao Zhe , Yang Caixuan , Duan Kaixin , Ren Luping , Song Guangyao 
Published: June 2023

ObjectiveIn the present network meta-analysis (NMA), we aimed to compare the effectiveness of daily and weekly treatment with glucagon-like peptide-1 receptor agonists for patients with nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM).MethodWe used Stata 17.0 for the NMA. Eligible Randomized controlled trials (RCTs) were searched in PubMed, Cochrane, and Embase databases until December 2022. Two researchers independently screened the available studies. The Cochrane Risk of Bias tool was used to assess the risk of bias in the included studies. We used GRADEprofiler (version3.6) to analyze the evidence certainty. Primary outcomes such as liver fat content (LFC), aspartate aminotransferase (AST), and alanine aminotransferase (ALT) levels, as well as secondary outcomes such as γ-glutamyltransferase (γGGT) and body weight, were evaluated. Then, each intervention was ranked by the surface under the cumulative ranking curve (SUCRA). As a supplement, we drew forest plots of subgroup using RevMan (version 5.4).ResultsFourteen RCTs involving 1666 participants were included in the present study. The NMA results showed that exenatide (bid) was the best treatment for improving LFC compared with other agents, liraglutide, dulaglutide, semaglutide (qw) and placebo), and the SUCRA values were 66.8%. Among five interventions (except exenatide (bid) and semaglutide (qw)) evaluated for AST outcome, and six interventions (except exenatide (bid)) evaluated for ALT outcome, semaglutide (qd) was the most effective drug (SUCRA (AST) = 100%, SUCRA (ALT) = 95.6%). The result of LFC in daily group was MD = -3.66, 95% CI [-5.56, -1.76] and in weekly GLP-1RAs group, it was MD = -3.51, 95% CI [-4, -3.02]. As to AST and ALT, the results in daily group versus weekly group were AST: MD = -7.45, 95% CI [-14.57, -0.32] versus MD= -0.58, 95% CI [-3.18, 2.01] and ALT: MD = -11.12, 95% CI [-24.18, 1.95] versus MD = -5.62, 95% CI [-15.25, 4]. The quality of evidence was assessed as moderate or low.ConclusionThe daily GLP-1RAs may be more effective in primary outcomes. And the daily semaglutide may be the most effective treatment for NAFLD and T2DM among the six interventions.
Burden of dilated perivascular spaces in patients with moyamoya disease and moyamoya syndrome is related to middle cerebral artery stenosis
Authors: Han Guangsong , Fan Xiaoyuan , Hong Yuehui , Zhou Lixin , Zhu Yicheng , Feng Feng , Yao Ming , Ni Jun 
Published: June 2023

Background and objectiveThe correlation between intracranial large artery disease and cerebral small vessel disease (CSVD) has become a noteworthy issue. Dilated perivascular spaces (dPVS) are an important marker of CSVD, of which cerebral atrophy has been regarded as one of the pathological mechanisms. DPVS has been found to be associated with vascular stenosis in patients with moyamoya disease (MMD), but the underlying mechanism remains unclear. The purpose of our study was to explore the correlation between the middle cerebral artery (MCA) stenosis and dPVS in the centrum semiovale (CSO-dPVS) in patients with MMD/moyamoya syndrome (MMS) and to determine whether brain atrophy plays a mediating role in this relationship.MethodsA total of 177 patients were enrolled in a single-center MMD/MMS cohort. Images of their 354 cerebral hemispheres were divided into three groups according to dPVS burden: mild (dPVS 0–10), moderate (dPVS 11–20), and severe (dPVS &gt; 20). The correlations among cerebral hemisphere volume, MCA stenosis, and CSO-dPVS were analyzed, adjusting for the confounding factors of age, gender, and hypertension.ResultsAfter adjustment for age, gender, and hypertension, the degree of MCA stenosis was independently and positively associated with ipsilateral CSO-dPVS burden (standardized coefficient: β = 0.247, P &lt; 0.001). A stratified analysis found that the subgroup with a severe CSO-dPVS burden exhibited a significantly higher risk of severe stenosis of the MCA [p &lt; 0.001, OR = 6.258, 95% CI (2.347, 16.685)]. No significant correlation between CSO-dPVS and ipsilateral hemisphere volume was found (p = 0.055).ConclusionIn our MMD/MMS cohort, there was a clear correlation between MCA stenosis and CSO-dPVS burden, which may be a direct effect of large vessel stenosis, without a mediating role of brain atrophy.
Bioactivity and nutritional quality of nutgall (Rhus semialata Murray), an underutilized fruit of Manipur
Authors: Singh Thangjam Surchandra , Kshetri Pintubala , Devi Asem Kajal , Langamba Pangambam , Tamreihao Keishing , Singh Heikham Naresh , Akoijam Romila , Chongtham Tania , Devi Chingakham Premabati , Singh Tensubam Basanta , Chongtham Sonia , Devi Yumnam Prabhabati , Kuna Aparna , Singh Soibam Giri , Sharma Susheel Kumar , Das Anup , Roy Subhra Saikat 
Published: June 2023

IntroductionUnderutilized fruits plays a significant role in socio economic, cultural, nutritional and ethnomedicinal status of tribal people. However, scientific studies on the nutritional and other pharmaceuticals/biological activities of these fruits are meagre. Hence, the present study dealt with the quantification of nutritional quality and deciphering the bioactivity of nutgall (Rhus semialata Murray syn. Rhus chinensis Mill.), an underutilized fruit crop mainly found in foothill tracks of Eastern Himalaya, India, China, Japan, Korea and other South East Asian countries.MethodsThe Rhus semialata Murray fruits were collected from five different locations in Purul sub-division, Senapati district, Manipur, India. The nutritional composition of the fruit pulp was analysed. Further the fruit pulp was extracted in methanol and water. The methanol and water extracts were studied for bioactivity properties such as antioxidant, antihyperglycemic, antihypertensive, antihyperuricemia, anti-tyrosinase, and antimicrobial activity.Results and discussionThe fruit was rich in essential fatty acids. The presence of linoleic and oleic acids, along with traces of docosahexaenoic acid and eicosapantaenoic acid, revealed the potential food value of the fruit. 59.18% of the total amino acid composition of the protein present was constituted by essential amino acids. The IC50 value of methanolic extract (MExt) and Water extract (WExt) of the fruit were recorded as 4.05 ± 0.22 and 4.45 ± 0.16 μg/mL, respectively, in the DPPH assay and 5.43 ± 0.37 and 11.36 ± 2.9 μg/mL, respectively, in the ABTS assay as compared to Ascorbic acid (3 and 5.4 μg/mL in DPPH and ABTS assay, respectively). The CUPRAC assay also showed a high antioxidant potential of MExt and WExt (1143.84 ± 88.34 and 456.53 ± 30.02 mg Ascorbic Acid Equivalent/g, respectively). MExt and WExt of the fruit were more active against α-glucosidase (IC50 of 1.61 ± 0.34 and 7.74 ± 0.54 μg/ mL, respectively) than α-amylase enzyme (IC50 14.15 ± 0.57 and 123.33 ± 14.7 μg/mL, respectively). In addition, the methanolic fruit extract showed low to moderate pharmacological potential in terms of antihypertensive (Angiotensin converting enzyme-I inhibition), antihyperuricemia (xanthine oxidase inhibition), anti-tyrosinase, and antimicrobial activity. The IC50 values of angiotensin-converting enzyme I inhibition, xanthine oxidase inhibition and tyrosinase inhibition were recorded as 13.35 ± 1.21 mg/mL, 93.16 ± 4.65 mg/mL, and 862.7 ± 12.62 μg/mL, respectively. The study evidently indicates that nutgall fruit is a potential source of phytonutrients, bestowed with commercially exploitable, multifaceted health benefits
Responses of two Acacia species to drought suggest different water-use strategies, reflecting their topographic distribution
Authors: Uni Daphna , Sheffer Efrat , Klein Tamir , Shem-Tov Rachamim , Segev Nitzan , Winters Gidon 
Published: June 2023

IntroductionSoil water availability is a key factor in the growth of trees. In arid deserts, tree growth is limited by very dry soil and atmosphere conditions. Acacia tree species are distributed in the most arid deserts of the globe, therefore they are well adapted to heat and long droughts. Understanding why some plants do better than others in some environments is a key question in plant science.MethodsHere we conducted a greenhouse experiment to continuously and simultaneously track the whole-plant water-balance of two desert Acacia species, in order to unravel their physiological responses to low water availability.ResultsWe found that even under volumetric water content (VWC) of 5-9% in the soil, both species maintained 25% of the control plants, with a peak of canopy activity at noon. Moreover, plants exposed to the low water availability treatment continued growing in this period. A. tortilis applied a more opportunistic strategy than A. raddiana, and showed stomatal responses at a lower VWC (9.8% vs. 13.1%, t4= -4.23, p = 0.006), 2.2-fold higher growth, and faster recovery from drought stress.DiscussionAlthough the experiment was done in milder VPD (~3 kPa) compared to the natural conditions in the field (~5 kPa), the different physiological responses to drought between the two species might explain their different topographic distributions. A. tortilis is more abundant in elevated locations with larger fluctuations in water availability while A. raddiana is more abundant in the main channels with higher and less fluctuating water availability. This work shows a unique and non-trivial water-spending strategy in two Acacia species adapted to hyper-arid conditions.
Impact of Heartfulness meditation practice on anxiety, perceived stress, well-being, and telomere length
Authors: Thakur Mansee , Patil Yogesh , Philip Sanjana T. , Hamdule Tahreem , Thimmapuram Jayaram , Vyas Nishant , Thakur Kapil 
Published: June 2023

ObjectiveExhaustion, stress, and burnout have all been found to be reduced using techniques like yoga and meditation. This study was carried out to check the effectiveness of Heartfulness practice (a form of meditation) on certain psychological and genetic variables.MethodsA total of 100 healthy individuals (aged 18–24) were recruited and randomized into two groups-Heartfulness intervention and control group. The intervention was carried out for 03 months. Participants from both groups were analysed for their cortisol levels and telomere length before and after the intervention. Psychometric measures of anxiety, perceived stress, well-being and mindfulness were carried out using Beck Anxiety Inventory (BAI), Perceived Stress Scale (PSS), WHO-Well-being Index (WHO-WBI) and Five Facet Mindfulness Questionnaire (FFMQ).ResultsThe cortisol levels in the meditators group significantly decreased (p &lt; 0.001) after the intervention as compared to the non-meditators group, whereas, the telomere length increased in the mediators group. This increase was not significant (p &gt; 0.05). Anxiety and perceived stress also decreased post intervention, and well-being as well as mindfulness increased, as assessed by the questionnaire tools, although the decrease in perceived stress was statistically insignificant (p &gt; 0.05). A negative correlation was observed between telomere length and cortisol (stress biomarker), whereas a positive correlation was found between telomere length and well-being.ConclusionOur data provide evidence that Heartfulness meditation practice can improve our mental health. Additionally, telomere length is shown to be affected by cortisol levels, and this meditation practice can also help to increase telomere length, and thereby slow down cellular aging. However, future studies with larger sample size are required to confirm our observations.
Influence of intravenous 10% amino acids infusion on serum albumin concentration in hypoalbuminemic dogs
Authors: Schneider Sabrina , Hartmann Katrin , Dörfelt René 
Published: June 2023

ObjectiveTo evaluate the effect of parenteral amino acid application in hospitalized hypoalbuminemic dogs.Materials and methodsMedical records of client-owned hypoalbuminemic dogs (albumin ≤ 25 g/L) were analyzed. Dogs receiving amino acids for only 1–2 days, receiving transfusions or surgery, or &lt;6 months of age were excluded. Dogs were grouped as those receiving intravenous amino acids (AA, 80 dogs) over 3 days and longer, and those without additional amino acid treatment (CON, 78 dogs). Duration of hospitalization, albumin, and total protein concentrations were compared between groups by Mann–Whitney U test. Course of albumin and total protein concentration was evaluated by Friedman test and Dunn’s multiple comparison test. Significance was set to p ≤ 0.05.ResultsDogs in group AA received 10% amino acid solution intravenously over median 4 days (3–11 days). No significant differences regarding survival and adverse effects were observed between groups. Dogs of group AA had significantly longer duration of hospitalization (median 8 days; 3–33 days) compared to group CON dogs (median 6 days, 3–24 days; p &lt; 0.001). Initial albumin concentration was lower in group AA compared to CON (p &lt; 0.001). This difference was no longer present on day 2 (p = 0.134).Conclusions and clinical relevanceIntravenous application of 10% amino acid solution in hypoalbuminemic dogs can improve albumin concentration after 2 days, but does not influence outcome.
Prevalence of cancer risk factors among transgender and gender diverse individuals: a cross-sectional analysis using UK primary care data
Authors: Brown Jalen , Pfeiffer Ruth M , Shrewsbury Duncan , OCallaghan Stewart , Berner Alison M , Gadalla Shahinaz M , Shiels Meredith S , Jackson Sarah S 
Published: June 2023

Background
Transgender and gender diverse (TGD) individuals experience an incongruence between their assigned birth sex and gender identity. They may have a higher prevalence of health conditions associated with cancer risk than cisgender people.

Aim
To examine the prevalence of several cancer risk factors among TGD individuals compared with cisgender individuals.

Design and setting
A cross-sectional analysis was conducted using data from the UKs Clinical Practice Research Datalink to identify TGD individuals between 19882020, matched to 20 cisgender men and 20 cisgender women on index date (date of diagnosis with gender incongruence), practice, and index age (age at index date). Assigned birth sex was determined from gender-affirming hormone use and procedures, and sex-specific diagnoses documented in the medical record.

Method
The prevalence of each cancer risk factor was calculated and the prevalence ratio by gender identity was estimated using log binomial or Poisson regression models adjusted for age and year at study entry, and obesity where appropriate.

Results
There were 3474 transfeminine (assigned male at birth) individuals, 3591 transmasculine (assigned female at birth) individuals, 131 747 cisgender men, and 131 827 cisgender women. Transmasculine people had the highest prevalence of obesity (27.5%) and ever smoking (60.2%). Transfeminine people had the highest prevalence of dyslipidaemia (15.1%), diabetes (5.4%), hepatitis C infection (0.7%), hepatitis B infection (0.4%), and HIV infection (0.8%). These prevalence estimates remained elevated in the TGD populations compared with cisgender persons in the multivariable models.

Conclusion
Multiple cancer risk factors are more prevalent among TGD individuals compared with cisgender individuals. Future research should examine how minority stress contributes to the increased prevalence of cancer risk factors in this population.
GAMBARAN PENGETAHUAN ORANG TUA KELAS 1 TENTANG PERTUMBUHAN GIGI PADA ANAK USIA SEKOLAH DASAR
Authors: Purnamasari Intan , Nurnaningsih Hera , Marah Laut Deru , Herijulianti Eliza 
Published: June 2023

Gigi bagi seorang anak sangat penting dalam tumbuh kembang anak itu sendiri, terutama pada usia anak Sekolah Dasar kelas 1, karena pada usia ini gigi permanen mulai erupsi dan perlu diperhatian agar tidak terjadi kerusakan dini. Penelitian ini bertujuan untuk mengetahui gambaran pengetahuan orang tua kelas 1 tentang pertumbuhan gigi pada anak usia Sekolah Dasar. Penelitian ini menggunakan metode penelitian deskriptif. Populasi dalam penelitian ini merupakan seluruh orang tua siswa kelas 1 disebuah SD di Kabupaten Subang yang berjumlah 21 orang. Dalam penelitian ini menggunakan total sampling. Instrumen penelitian yang digunakan dalam penelitian ini menggunakan kuesioner dalam bentuk google form. Data akan di analisis dan disajikan dalam bentuk tabel distribusi frekuensi yang menggambarkan situasi pengetahuan orang tua siswa tentang pertumbuhan gigi. Hasil penelitian menunjukan bahwa sebanyak 47,6% orang tua kurang mengetahui tentang periode pertumbuhan gigi kemudian sebanyak 66,7% orang tua kurang mengetahui tentang faktor-faktor yang mempengaruhi erupsi gigi. Tingkat pendidikan responden tentang pengetahuan pertumbuhan gigi terdapat dalam kategori kurang adalah orang tua dari kelompok lulusan SD yaitu sebesar 33,3% sedangkan tingkat pekerjaan responden pada aspek pengetahuan tentang pertumbuhan gigi terdapat dalam kategori kurang adalah orang tua dari kelompok ibu rumah tangga yaitu sebesar 47,6%.
HISTORICAL AND ARCHITECTURAL ANALYSIS OF D.M. POZHARSKIY PAROCHIAL SCHOOL IN SUZDAL
Authors: Savel'eva N. 
Published: June 2023

This article presents a historical and architectural analysis of the unveiled object of cultural heritage of the Vladimir region - the D.M. Pozharsky parochial school at the Spaso–Efimiev Monastery in the city of Suzdal. The analysis was carried out during the official historical and cultural expertise to state and determine the value category of the object, define the subject of protection, justify the listening of the object in the list of regional objects of cultural heritage.
The building date of the object was clarified, historical spatial and plastic elements were determined, modern distortions and losses were revealed. The specifics of the plan setting are exposed, a detailed description of the architectural features of the monument is presented.
The article presents a detailed description of the architectural features of the monument, reveals the specifics of the town-planning situation. The illustrative material made by the author is presented in the form drawings of plan, major facade and individual architectural elements. A brief historical reference and analysis of existing textual and archival materials containing historical data and information about the value of the studied object are added.
The object of the study is the building of the D.M. Pozharsky parochial school. The subject of the study are the architectural and stylistic features of the structure
According to the results of the study, the author provided the conclusion about the high degree of historical material preservation, significant historical, cultural, architectural and urban planning value of the object, and possible options for modern use