bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence of baseline hypocalcemia and symptomatic hypocalcemia during leukapheresis
Authors: Bray Kimberly , Lynde Carolyn , Vu Trizzie , Patterson Amy , Reich Richard R. , Mason Tina M. , Liu Hien D. 
Published: July 2023

AbstractSymptoms of hypocalcemia are reported in up to 50% of patients undergoing leukapheresis procedures. There is no set standard of practice for administering calcium supplementation in the prevention or treatment of hypocalcemia symptoms. The goal of this descriptive, retrospective study was to determine the prevalence of baseline hypocalcemia and symptomatic hypocalcemia during leukapheresis with acid citrate dextrose solution A and to identify patient characteristics associated with symptomatic hypocalcemia. Three percent of patients were found to have hypocalcemia before leukapheresis with 35% experiencing hypocalcemia symptoms during leukapheresis. Older age, higher albumin levels, and longer procedure time were associated with increased risk of hypocalcemia symptoms.
Therapeutic leukocytapheresis for leukostasis in chronic lymphocytic leukemia: A case report and literature review
Authors: Auen Thomas , Renavikar Pranav , Habib Esther , Koepsell Scott A. 
Published: July 2023

AbstractChronic lymphocytic leukemia (CLL) is a clonal mature B‐cell neoplasm with a typically indolent clinical course. Though most clinicians follow these neoplasms through observation alone, an aggressive transformation to prolymphocytic leukemia, diffuse large‐B‐cell lymphoma (Richter transformation) or classical Hodgkin lymphoma requires immediate attention. We present a case of extreme leukocytosis (>1 million/μL) in a previously diagnosed CLL patient. Due to symptomatic leukostasis, she was started on cytoreductive therapies including leukocytapheresis. After three rounds of leukocytapheresis (LCP) and concurrent chemotherapy, her white blood cell count decreased from a maximum 1262 × 103/μL to 574 × 103/μL. To our knowledge, CLL with symptomatic leukostasis that required therapeutic LCP is rarely reported in literature. We propose that therapeutic LCP is of value in such rare, yet dangerous settings like our case.
End‐of‐life care management for older adults at home by multidisciplinary professionals in Japan
Authors: Kaneda Akiko , Kanoya Yuka 
Published: July 2023

AbstractBackgroundPopulation aging is a global phenomenon, and there is an urgent need to establish community‐based integrated care systems for a sustainable society. In particular, the needs of home‐dwelling older adults are multifaceted, encompassing areas such as medical care, nursing care, and welfare. Therefore, it is necessary to implement comprehensive care management that utilizes social resources suitable for diverse needs. This study aims to comprehensively describe care management practices by various professionals for home‐dwelling older adults in the end‐of‐life (EOL) period.MethodsThis study adopted a qualitative analysis method using conventional content analysis. We conducted semi‐structured interviews of 20 multidisciplinary professionals from February to March 2020.ResultsMultidisciplinary professionals ensured continuity of care by implementing care management as necessary when providing care to older adults who desired to stay at home until the end. Seven categories of EOL care management practices for home‐dwelling older adults by multidisciplinary professionals were generated: (1) support to enable discharge to home; (2) decision‐making support that captures the intention of the older adult without missing opportunities; (3) building a team system to realize the desired life and EOL; (4) family support for the entirety of the EOL period, (5) symptom control aimed at the realization of wishes; (6) emotional support for acceptance of the EOL period; (7) spiritual support.ConclusionsMultidisciplinary professionals, including care managers, collaborating in a mutually complementary manner by sharing a comprehensive understanding of care management might prevent knowledge fragmentation and ensure that older adults receive home‐based EOL care.
Migrating 1H NMR peaks in the benzylation of adenine reveal the disruptive Kornblum oxidation in DMSO
Authors: Buyens Dominique M. S. , Pilcher Lynne A. 
Published: July 2023

AbstractThe alkylation of adenine using alkyl halides under basic conditions in dimethyl sulfoxide (DMSO), a common reaction to achieve N9‐alkylated adenine derivatives, is often low yielding with unreacted adenine and complicated reaction mixtures. Herein, we report the reaction monitoring of the alkylation of adenine in DMSO in the presence of NaH using benzylic halides via real‐time 1H NMR spectroscopy. NMR analysis revealed that under these generally used reaction conditions, the adeninate anion starting material is protonated as the anionic nucleophile abstracts a labile proton from an alkoxy sulfonium ion intermediate formed via the Kornblum oxidation reaction. To prevent the protonation of the adeninate anion, the reaction was performed in the presence of a mop‐up base DBU. Simultaneously increasing the concentration of the alkyl halide and the mop‐up base in a 1:1 ratio resulted in a complete reaction; however, increasing the temperature of the reaction promoted depletion of the starting material by protonation and hence reduced conversion to products. This result implies that heating of such electrophiles in DMSO should be avoided. The addition of a mop‐up base can help resolve the complication of protonation arising from the Kornblum oxidation reaction in alkylation reactions under similar conditions.
Establishment and characterization of a novel reverse genetic system of BK polyomavirus
Authors: Liu Nannan , Gu Chenjian , Yang Yang , Gao Zixiang , Kang Ning , Liu Jing , Xie Youhua 
Published: July 2023

AbstractBK polyomavirus (BKV) is a small non‐enveloped DNA virus. BKV infection or reactivation may cause BKV‐associated nephropathy and hemorrhagic cystitis in immunosuppressed transplant recipients. No effective antivirals or prevention strategies are available against BKV infections. The current BKV reverse system employs the transfection of purified full‐length linear viral genomes released by enzyme digestion from BKV genomic plasmids. The method is laborious and often results in variable DNA yield and quality, which can affect the efficiency of transfection and subsequent formation of circular viral genomes in cells. In this study, we report the generation of circular viral genomes by Cre‐mediated DNA recombination in cells directly transfected with BKV precursor genomic plasmids. The novel system supported efficient viral expression and replication, and produced a higher level of infectious virions compared with the transfection with linear BKV genomes. Furthermore, we successfully constructed recombinant BKV capable of reporter gene expression. In conclusion, the novel BKV reverse genetic system allows for simpler manipulation of BKV genome with better virus yield, providing a tool for the study of BKV life cycle and antiviral screening.
Using online machine translation in international scholarly writing and publishing: A longitudinal case of a Chinese engineering scholar
Authors: Zou Cuiying , Gong Wei , Li Ping 
Published: July 2023

AbstractScholars who use English as an additional language (EAL) worldwide are under increasing pressure to write and publish in English due to the pervasive publish‐or‐perish culture and the growing dominance of English in academia. While previous studies have focused either on textual differences between EAL scholars' writing and native writers', or explored the difficulties EAL scholars meet and strategies they employ in the process, this paper examines a longitudinal case of a Chinese engineering scholar using online machine translation (MT) to support his academic writing and publishing in English. Drawing from the technology acceptance model as the theoretical background, this study shows that online MT can be a crucial support for scholars with limited English proficiency in the process of preparing a manuscript, submitting it and communicating with editors and reviewers. Frequently occurring problems in machine‐translated academic texts include improper use of technical terms, use of informal language and the inclusion of grammatical mistakes. However, in the last decade, online MT has made great improvements in academic translation. We believe these findings can empower EAL scholars to effectively use online MT in academic English writing and inspire educators to help novice scholars mobilize various high‐tech tools such as online MT to support their writing and international publishing.
Assessment of learning health system science competency in the equity and justice domain
Authors: Franklin Patricia D. , Drane Denise 
Published: July 2023

AbstractSeven knowledge domains were originally defined for the learning health system (LHS) scientist. To assess proficiency in each of these domains, we developed and published an assessment tool for use by emerging LHS scientists and training programs. (LHS, October 2022). In mid‐2022, the AHRQ adopted an eighth LHS knowledge domain, Equity and Justice. The addition of this eighth domain emphasizes the importance and centrality of equity in the LHS and improvement science. To extend our prior LHS competency assessment, we developed a proficiency assessment for the new equity and justice domain. Content experts and trainees iteratively defined, reviewed, and edited the assessment criteria. The items were developed by trainees and experts at one LHS training center with experience conducting research focused on healthcare inequities among marginalized populations. The proficiency assessment criteria for the Equity domain apply the same four levels of mastery: “no exposure,” “foundational awareness,” “emerging,” and “proficient” as were used for original competencies. LHS training programs can use these proficiency criteria to monitor skills among emerging scientists across the eight domains, with particular attention to equity and justice.
FRANCES HESSELBEIN AND THE POWER OF EMPATHY
Authors: Ivany Robert 
Published: July 2023

AbstractThe author retired from the Army as a major general and became the president of the University of St. Thomas in Houston, Texas, where he served for 14 years. He writes that “for the past 21 years, she had generously served as my (and many others) mentor as I transitioned from a career in the Army to the academic world and then again as I became a faculty member at Thayer Leadership.” He was particularly impressed by “her remarkable ability to empathize. I watched her relate to and inspire young students from inner city New York, college students from China and Africa, combat veterans, CEOs of our largest corporations, and executives of philanthropic organizations.”
HOW TO BE AND DO TO CREATE VALUE FOR ALL THE STAKEHOLDERS AND THE GREATER GOOD
Authors: Mulally Alan 
Published: July 2023

AbstractThe author, the former President and CEO of Boeing Commercial Airplanes and former CEO of the Ford Motor Company, recounts his long friendship and collaboration with Frances Hesselbein. Like so many others, he initially met her through the pioneering executive coach Marshall Goldsmith. “Over these many decades,” the author writes, “before and since Frances and I met, my life’s work, my love and service, has been developing, implementing, and sharing the ‘Working Together’ Leadership and Management System, with its process and behaviors that support the Be and the Do, the character and competencies, and the principles and practices of leaders who create value for all the stakeholders and the greater good. Who Frances was, her character and heart, are hugely responsible for encouraging my leadership service journey.”
BRIGHT FUTURE: EMBRACING FRANCES HESSELBEIN’S EMBRACE OF YOUNGER GENERATIONS
Authors: Santucci Julia M. 
Published: July 2023

AbstractThe author is a senior lecturer in intelligence studies and Director of the Johnson Institute for Responsible Leadership and the Frances Hesselbein Leadership Forum at the University of Pittsburgh, and as such worked closely with Frances. She writes that she is “most inspired by Frances’ embrace of young leaders throughout her storied career. She always recognized the potential in future generations, and she created opportunities for young people to realize that potential.” The Forum remains a crucial locality for Frances’ ideas and legacy: “Our student‐centered programs—the Hesselbein Lecture Series, the Hesselbein Executive Coach, and the Leadership Program in International Affairs—aim to instill in our students the core values of servant leadership, including humility, accountability, empathy, and stewardship. These programs also create opportunities for students to engage with diverse leaders from all sectors so that they can learn from these individuals and see themselves similarly as leaders.”
Logics of upsets of De Morgan lattices
Authors: Přenosil Adam 
Published: July 2023

AbstractWe study logics determined by matrices consisting of a De Morgan lattice with an upward closed set of designated values, such as the logic of non‐falsity preservation in a given finite Boolean algebra and Shramko's logic of non‐falsity preservation in the four‐element subdirectly irreducible De Morgan lattice. The key tool in the study of these logics is the lattice‐theoretic notion of an n‐filter. We study the logics of all (complete, consistent, and classical) n‐filters on De Morgan lattices, which are non‐adjunctive generalizations of the four‐valued logic of Belnap and Dunn (of the three‐valued logics of Priest and Kleene, and of classical logic). We then show how to find a finite Hilbert‐style axiomatization of any logic determined by a finite family of prime upsets of finite De Morgan lattices and a finite Gentzen‐style axiomatization of any logic determined by a finite family of filters on finite De Morgan lattices. As an application, we axiomatize Shramko's logic of anything but falsehood.
Improving the blend of multiple weather forecast sources by Reliability Calibration
Authors: Rust Fiona M. , Evans Gavin R. , Ayliffe Benjamin A. 
Published: July 2023

AbstractCreating a forecast that is seamless across time yet is optimal at each forecast validity time is often achieved by blending forecasts from multiple Numerical Weather Prediction models (or using other forecast sources, such as an extrapolation nowcast). With the increasing usage of convection‐permitting ensemble models at shorter lead times, the blending of these forecasts with longer‐range ensemble models with parameterized convection can lead to a clear transition from one forecast source to another. This is particularly noticeable when visualizing the evolution of the gridded forecast. Calibrating the forecast sources with a common truth prior to blending provides a method of improving forecast skill whilst also unifying the characteristics of the forecasts to create a smoother blend throughout the evolution of the forecast. In this work, a non‐parametric method for calibrating the reliability of the forecast without degrading the forecast resolution is assessed for its usability for gridded precipitation rate and total cloud amount forecasts. Reliability is markedly improved resulting in a similar skill between forecast sources during the blending period. Further refinements to the technique removed artefacts in the gridded forecasts. Caveats, including a reduction in sharpness following calibration, are also presented.
Development and psychometric evaluation of the nurses' Work Values Scale
Authors: Hara Yukari , Asakura Kyoko , Yamada Masako , Takada Nozomu , Sugiyama Shoko 
Published: July 2023

AbstractAimThis study aimed to develop the nurses' Work Values Scale (WVS) to determine how important certain values are for nurses and to psychometrically test the scale.DesignInstrument development and validation study.MethodA two‐phase scale development process comprising item generation, scale improvement and psychometric property evaluation was used. In the first phase, scale items were identified. In the second phase, item and exploratory factor analyses were performed in Study 1, and confirmatory factor analysis, validity verification and reliability verification of the nurses' WVS were performed in Study 2.ResultsAs a result of the analysis, a scale of 30 items with four subdomains was developed. In convergent validity and reliability verification, it was shown that the nurses' WVS has acceptable validity and reliability.No Patient or Public ContributionPatients or members of the public were not involved in this study.
Functional Brain Regions Linked to Tinnitus Pathology and Compensation During Task Performance: A Systematic Review
Authors: Jimoh Zaharadeen , Marouf Azmi , Zenke Julianna , Leung Ada W.S. , Gomaa Nahla A. 
Published: July 2023

AbstractObjectiveTo systematically search the literature and organize relevant advancements in the connection between tinnitus and the activity of different functional brain regions using functional magnetic resonance imaging (fMRI).Data SourcesMEDLINE (OVID), EMBASE (OVID), CINAHL (EBSCO), Web of Science, ProQuest Dissertations & Theses Global, Cochrane Database of Systematic Reviews, and PROSPERO from inception to April 2022.Review MethodsStudies with adult human subjects who suffer from tinnitus and underwent fMRI to relate specific regions of interest to tinnitus pathology or compensation were included. In addition, fMRI had to be performed with a paradigm of stimuli that would stimulate auditory brain activity. Exclusion criteria included non‐English studies, animal studies, and studies that utilized a resting state magnetic resonance imaging or other imaging modalities.ResultsThe auditory cortex may work to dampen the effects of central gain. Results from different studies show variable changes in the Heschl's gyrus (HG), with some showing increased activity and others showing inhibition and volume loss. After controlling for hyperacusis and other confounders, tinnitus does not seem to influence the inferior colliculus (IC) activation. However, there is decreased connectivity between the auditory cortex and IC. The cochlear nucleus (CN) generally shows increased activation in tinnitus patients. fMRI evidence indicates significant inhibition of thalamic gating. Activating the thalamus may be of important therapeutic potential.ConclusionPatients with tinnitus have significantly altered neuronal firing patterns, especially within the auditory network, when compared to individuals without tinnitus. Tinnitus and hyperacusis commonly coexist, making differentiation of the effects of these 2 phenomena frequently difficult.
Theoretical solutions of short glass fiber/polyurethane composite beams based on Hamiltonian principle
Authors: Zhao Fei , Zhou Bo , Zhu Xiuxing , Wang Haijing 
Published: July 2023

AbstractShape memory polymers (SMP) and its composites (SMPC) have gained popularity for their potential in intelligent structures fields. Developing a reliable mechanical model to accurately describe mechanical behavior of its intelligent structures is important for both theory and practice. This paper presents a novel mechanical model for describing the mechanical behavior of short glass fiber/polyurethane (GF/PU) composite beams, based on a constitutive model of SMP and incorporating principles from composite mechanics theory, the Hamiltonian principle and Euler–Bernoulli beam theory. The model includes kinematic equations and material parameter equations. Based on the constitutive equations of SMP, coupled with Euler–Bernoulli beam theory and Hamilton's principle, the kinematic equations of GF/PU composite beam are established. Additionally, a correction factor was proposed and employed to modify the material parameter equation of SMP, which was then combined with the mechanics theory of composite materials to establish a material parameter equation for composite beams. Taking a simply supported beam as an example, we solve the model using Fourier method and simulate and analyze the material parameters properties, static and viscous mechanical behaviors properties, and shape memory behavior properties of the GF/PU composite beam. The results show that the GF volume fraction, temperature correction coefficient, regularization parameter, and contact parameter have a significant impact on the material parameters of GF/PU composite materials and the material parameters of composite beams have important effects on their mechanical properties. By adjusting material parameters, ideal mechanical properties can be obtained for the GF/PU composite beam. This study provides a theoretical foundation for intelligent beam design and analysis based on SMP and SMPC.Highlights
A novel viscoelastic mechanical model for GF/PU composite beam is proposed.
Effect of composite components on GF/PU composite is studied.
Kinematic equations based on Hamiltonian principle is established.
Material parameter equation including corrected parameter is established.
Integrating conversations about disordered eating in children and young people into routine type 1 diabetes care: a practical guide
Authors: Wakelin Katherine E , Read Rebecca K , O’Donnell Nicola , Baker Marisa , Satherley Rose‐Marie , Stewart Rose , Jones Christina J 
Published: July 2023

AbstractA higher proportion of children and young people (CYP) with type 1 diabetes (T1D) present with disordered eating compared to CYP without T1D. Due to the complexities of T1D management in addition to eating disorder treatment, it is essential to discuss T1D and Disordered Eating (T1DE) with families to screen early and frequently. This enables those most vulnerable to be identified and treated early.The aim of this paper was to: (1) identify the barriers for health care professionals (HCPs) communicating with families about T1DE; and (2) identify practical ways to overcome these barriers. This paper discusses qualitative data from interviews with 10 parents about how they would like conversations about T1DE to be facilitated by HCPs. All parents had a child aged 11–14 with T1D and were recruited through the PRIORITY trial.Four main barriers to communicating about T1DE were identified. These were: (1) parents fearing that conversation about T1DE will increase the likelihood of T1DE developing; (2) psychology not being integrated into routine care; (3) concerns about sensitive communication around the topic of weight; and (4) parents feeling overwhelmed. Practical suggestions for ways in which HCPs can overcome these barriers are discussed.The paper provides a practical guide for HCPs to help them facilitate conversations about T1DE with families in order to allow earlier detection, prevention and intervention of disordered eating within this population. Copyright © 2023 John Wiley & Sons.
An overview of PHA templates and checklists developed for a refining system and lessons learned
Authors: Wolbers Joshua 
Published: July 2023

AbstractThe Chevron Refining organization has completed a multi‐year effort to create process hazard analysis (PHA) templates and checklists to improve the consistency and quality of PHAs. The goal of this study is to provide an overview of the content, development process, and lessons learned. The lessons learned included the following. Members of PHA teams and SMEs have differing experiences and perspectives on the risk of loss of containment, necessitating a standardized method for developing consequences and modifiers. Typical PHA teams (e.g., facilitator, process and/or design engineer, and operator) will have differing levels of engineering and operating experience, making a thorough understanding of the various types of equipment and processes in a typical refining unit impractical. PHA teams cannot realistically bring in SMEs on an as needed basis to aid with the analysis. Concerns that templated solutions might cause PHA teams to lose their creativity and focus only on the templates, and that templates might omit or incorrectly assess a hazard, have been outweighed by the benefits of the templates.