bluuebunny/crossref_metadata_2025_split huggingface dataset:
Does the addition of bioglass 45S5 to a bleaching gel influence enamel color, roughness, and mineral content?
Authors: Dascanio Rafael , Coelho Camila , Souza Marina , Zanotto Edgar , Cavalli Vanessa 
Published: May 2023

Abstract
Objective To evaluate color change, surface roughness, microhardness, and morphology of enamel submitted to bleaching with 35% hydrogen peroxide (HP) gels associated with different concentrations of bioglass 45S5 (BG).Methods Enamel blocks (n = 10) were submitted to a positive control (PC): 35% HP bleaching; HP_BG: HP associated with a gel containing BG at concentrations of 0, 2.5, 5, 7.5, 10 wt% and negative control (NC), no treatment in 3 sessions of 40 min each and 7 days apart. The blocks were kept in artificial saliva up to 14 days after bleaching. Color change (ΔE00), color parameters (ΔL, Δa, Δb), roughness average (ΔRa), and surface microhardness were evaluated at baseline (T0), after 24h (T1), and 14 days elapsed from bleaching treatment (T2). The percentage of surface hardness loss (%SHL) was calculated and the enamel was characterized at T2 by scanning electron microscopy (SEM) and energy dispersive spectroscopy (EDS). Data were subjected to ANOVA and Tukey test (α = 0.05).Results No differences in ΔE00 and Δb were observed among HP-containing groups, regardless of the BG concentration (p > 0.05). Additionally, no differences were noted in ΔRa, ΔL, and Δa among the groups (p > 0.05). However, BG incorporation into the bleaching gels prevented enamel mineral loss in comparison to PC immediately after bleaching treatment (T1, p < 0.05). At T2, 10% BG was the only group to keep enamel mineral content (p < 0.05). Conclusion: The addition of BG did not affect the HP bleaching efficacy and the incorporation of 10% BG into the HP bleaching agent exhibited a positive remineralizing effect.Clinical Relevance: It was found with BG has the potential to reverse the harmful effects on the dental surface during the bleaching protocol.
Efficacy and complications of blocking screws fixation in the treatment of lower limb long bone fracture: a Meta-analysis
Authors: Jin Zhaoguo , Wang Ding 
Published: May 2023

Abstract
Background: The incidence of long tubular bone fracture is high, accounting for about 4% of emergency trauma, especially the proportion of long tubular bone (mainly femoral shaft and tibiofibular shaft) in the lower limb is the highest.
Methods: To find controlled trials on the effectiveness and side effects of using blocking screws to fixate lengthy bone fractures in the lower leg, the computer searches eight repositories. The examination of the data was carried out utilizing RevMan 5.3 program following a thorough assessment of the overall quality of the research.
Results: This investigation eventually comprised 15 papers. Based on the investigation of 15 studies, the fracture healing time was substantially shorter in the test group than that of the control group (SMD: -2.18; 95% Cl: -3.17,-1.20; P<0.001). We revealed no statistically significant differences between the fracture healing rates of comparative groups (OR:1.09; 95% Cl: 0.98,1.20; P=0.098). The operation time of the experimental group was significantly greater than that of the control group (SMD:15.81; 95% Cl: 4.28,27.34; P=0.007). When compared to the control group, the intraoperative bleeding was much less in the experimental group (SMD: -75.60; 95% Cl: -127.93,-23.27; P=0.005). Our investigation showed that the complications of the experimental group were much fewer than those of the contrasted group (OR: 0.51; 95% Cl: 0.31, 0.84; P=0.008).
Conclusion: The findings of the present investigation imply that individuals with lower limb long bone fractures (LLLBF) may benefit from intramedullary nailing in conjunction with blocking screws, as evidenced by fracture healing time, fracture healing rate, operation time, intraoperative bleeding, complications, and the above conclusions need to be verified by more high-quality studies.
High Expression of RAB32 Predicts Adverse Outcomes: A Potential Therapeutic Target for Glioblastoma
Authors: Huang Liji , Chi Yue , Wang Xindi , Zhang Sinan , Su Xiangyue , Jiang Xudong , Cao Yanfei , Zhang Lina 
Published: May 2023

Abstract
RAB32 is a potential prognostic marker that is overexpressed in a variety of cancers. The purpose of this study was to investigate the expression and function of RAB32 in glioblastoma (GBM).The expression data of RAB32 were obtained by accessing TCGA, CGGA and GEPIA databases, which were verified by western blot and immunohistochemistry. The prognostic value of RAB32 methylation was carefully examined using cBioPortal and MethSurv. GSEA was used to analyze cancer-related signaling pathways that may be activated by high RAB32 expression. The correlation between RAB32 and GBM immunoinfiltration was studied by accessing TISIDB database.The effects of RAB32 on proliferation, migration and invasion of GBM cells were predicted by Colony Formation Assay, CCK-8 assay and Transwell assay. In this study, RAB32 expression was up-regulated in GBM compared to normal brain tissue. Survival analysis showed that high expression of RAB32 was an independent risk factor for overall survival in glioma patients. RAB32 methylation was negatively correlated with RAB32 expression, and the overall survival rate of RAB32 hypomethylated patients was lower than that of RAB32 hypermethylated patients.Through functional enrichment analysis, we found that the RAB32 overexpression significantly activated multiple signaling pathways. Immunoassay results showed that RAB32 expression was correlated with immune infiltration of tumor microenvironment. Knocking down the expression of RAB32 gene significantly inhibited the proliferation, migration and invasion of glioma cells. Our results show that RAB32 is a key factor affecting the prognosis of patients with GBM, and its targeting may provide a new treatment for patients with GBM.
Conversion of Lignocellulosic Waste Into Cyclohexanol and 1-methyl-1,2- Cyclohexanediol Using New Hydrotalcite-based Catalysts
Authors: PEREZ WILLIAM , MARIN JAMES , ARNOLD ULRICH , RIOS LUIS 
Published: May 2023

Abstract
Cyclohexanol and 1-methyl-1,2-cyclohexanediol were produced via the hydrotreating of guaiacol, using new hydrotalcite-based nickel (HT-Ni-R) and cobalt (HT-Co-R) catalysts.. Guaiacol is the most representative model compound for lignin-derived bio-oils. Catalysts were prepared by co-precipitation of the metals (Mg-Al, Ni or Co) followed by direct reduction with H2 at high temperature (550°C). Active species are highly dispersed Ni0 and Co0 particles formed upon reduction of part of the Ni2+ and Co2+. The main effect of the new synthesis procedure is to remarkably increase the dispersion of these metal particles, compared to those on the supported catalysts. Cobalt catalyst is more efficient for oxygen removal than the nickel catalyst, but this latter is more efficient for aromatic´s hydrogenation. HT-Ni-R produced 1-methyl-1,2-cyclohexanediol as the main product (70%). The main reaction pathway with HT-Co-R was the formation of cyclohexanol (41%). The high metal dispersion induced by the proposed synthesis procedure is the most important advantage of the new catalysts allowing the obtention of products with added value from potential renewable resources as lignin.
Exploring Determinants of Early Marriage among Women in Bangladesh: A Multilevel Analysis
Authors: Rashid Md. Mamunur , Al-Amin Md. , Rahman Mostafizur , Roy Tapan Kumar , Rahman Mosiur 
Published: May 2023

Abstract
Background: Early marriage is considered a global problem both in developed and developing countries because it deprives women of their basic human rights. This study aimed to identify the prevalence and determinants of early marriage among women in Bangladesh.
Methods: We used the most recent Bangladesh Demography and Health Survey 2017-18 data. This study analyzed a weighted sample of 20,127 reproductive-aged women. The significant factors related to early marriage were identified using the multilevel logistic regression method. An adjusted odds ratio with a 95% confidence interval was used to explain the significant factors.
Results: Our findings showed that women’s age, education, place of residence, division, wealth index and religion had a substantial effect on early marriage. However, it can be concluded that women with higher educational status (OR= 0.07, 95% CI= 0.06-0.08) and rich household families (OR= 0.89, 95% CI= 0.80-0.99) had a lower chance of engaging in early marriage than women with no education and poor household families.
Conclusion: The prevalence of early marriage is still high in Bangladesh. The study recommended that attention to women’s education, place of residence, regions, wealth index and religion might help to reduce early marriage in Bangladesh.
High-capacity scattering-augmented optical encryption
Authors: Chang Xuyang , Jiang Shaowei , Yang Liming , Zhan Xinrui , Liu Shicong , Li Daoyu , Yan Rong , Gao Zhen , Zheng Guoan , Zhang Jun , Bian Liheng 
Published: May 2023

Abstract
Optical encryption is an emerging technique that uses optical systems to securely encode and decode information for data transmission. In this study, we present an integrated optical encryption platform that consists of a scattering-augmented ptychographic encryption system, a transmission-efficient compressive sampling strategy, and a high-capacity decryption algorithm based on a hybrid model-data driven approach. Our encryption system leverages random light scattering as a physical unclonable function, enabling the encoding of complex object wavefronts with high optical throughput. In contrast to traditional encoders that offer insecure pseudo-randomness, the light scattering process ensures true randomness in the reported platform. To optimize transmission efficiency, we implement a compressive sampling strategy that reduces data transmission volume by at least one order of magnitude. Moreover, we devise a decryption algorithm that merges model-driven optimization with data-driven deep learning, effectively addressing the highly underdetermined retrieval task and providing robust decryption against various measurement noise and communication interference. The efficacy of our system is corroborated by an integrated optical prototype capable of encrypting ten million of pixels within minutes. Communication experiments confirm the resilience of our decryption algorithm, which retrieves high-fidelity results even under extreme transmission conditions characterized by a 20% bit error rate. Our innovative encryption technique presents a comprehensive solution for high-capacity data transmission, fortified by scattering-augmented security.
Proportion of late initiation of Antenatal Care service and its associated factors at govermental health institutions, Bahir Dar, North West Ethiopia:Institutional based cross sectional study.
Authors: Alemayehu Bezawit Abeje 
Published: May 2023

Abstract
Background: Antenatal care is a care for pregnant women with the aim of preventing, detecting and treating health problems in both the fetus and mother. Late initiation of antenatal care attendance confines early detection and treatment of complications. The aim of this study was to determine the proportion of late initiation of antenatal care visit and associated factors among pregnant women.
Methods: Facility based cross sectional study was conducted from April 01 to May 30, 2021 on 612 participants.The study participants were selected by systematic random sampling technique. Data was coded, entered and cleaned in Epi-data version 3.1 and exported to Statistical package for social sciences version 23 software for analysis. Bivariate and multivariate analysis was done. Variables with P<0.25 in the bivariate analysis were included in to multivariate logistic regression model and statistical significance was declared at P< 0.05.
Results: In this study proportion of late initiation of antenatal care visit was 42.3 % [95% CI: 38.6 %,46.4 %].Respondents educational status of secondary school [AOR= 12.10, 95% CI: 2.50, 21.32], husbands' educational status of secondary school [AOR=4.27, 95% CI: 1.20, 13.78], current health problem [AOR= 2.65, 95% CI: 1.40, 10.04] and awareness about danger signs of pregnancy [AOR=10.1; 95% CI: 5.6, 18.20] were significant factors.
Conclusion: In this study late initiation of antenatal care visit was most important public health issue. Women and their husbands’ educational status, awareness on danger signs of pregnancy and health problem in current pregnancy were significant factors. Responsible bodies should create awareness of danger sign of pregnancy and improve women education by strengthening adult education in the community.
Topical streptomycin irrigation of lesions to prevent postoperative site infections in spinal tuberculosis: a retrospective analysis
Authors: QiangDeng  
Published: May 2023

Abstract
Purpose: Topical streptomycin irrigation of the lesion is now commonly used in spinal tuberculosis surgery to achieve a better anti-tuberculosis treatment outcome. Surgical site infection (SSI) is one of the most common complications after spinal tuberculosis surgery, yet no definitive report of focal local streptomycin irrigation in postoperative spinal tuberculosis infection has been seen. This study analysed data relating to SSI after surgical treatment of spinal tuberculosis with this regimen.
Methods: Sixty-five patients with spinal tuberculosis requiring surgical treatment were divided into two groups, 31 in the observation group and 34 in the control group, according to the presence or absence of intraoperative topical streptomycin irrigation of the lesion. The general data, operation time, intraoperative bleeding, ESR, CRP, time of antibiotic use, total drainage, wound infection rate and secondary debridement rate of the two groups were compared.
Results: The ESR and CRP levels of patients in the observation group were significantly lower than those in the control group at one week postoperatively (p<0.05); the mean length of stay in the observation group was 17.19 ± 2.88 days; significantly lower than that of the control group, which was 19.82 ± 4.03 days (p=0.004); the mean duration of postoperative antibacterial drug use in the observation group was 5.71 ± 1.60 days, significantly lower than that of the control group (7.82 ±1.75) (p<0.001), and 2 cases of SSI occurred in each of the two groups, all of which were treated with debridement surgery and healed, with no statistically significant difference (both p values >0.05).
Conclusion: The use of topical streptomycin irrigation of the lesion during surgical procedures for spinal tuberculosis had no significant effect on the incidence of SSI, however, it helped to control the level of infection in the postoperative period, reducing the average number of days patients stayed in hospital and the length of postoperative antibiotic use.
Determinants of tap water mistrust among Phoenix, Arizona Latinx adults
Authors: Colburn Abigail T. , Buman Matthew P. , Wutich Amber , Vega-López Sonia , Ohri-Vachaspati Punam , Kavouras Stavros A. 
Published: May 2023

AbstractThe purpose of this investigation was to characterize factors that predict tap water mistrust among Phoenix, Arizona Latinx adults. Participants (n = 492, 28 ± 7 years, 37.4% female) completed water security experience-based scales and an Adapted Survey of Water Issues in Arizona. Binary logistic regression determined odds ratios (OR) with 95% confidence intervals (95% CI) for the odds of perceiving tap water to be unsafe. Of all participants, 51.2% perceived their tap water to be unsafe. The odds of mistrusting tap water were significantly greater for each additional favorable perception of bottled compared to tap water (e.g., tastes/smells better; OR = 1.94, 95% CI = 1.50, 2.50), negative home tap water experience (e.g., hard water mineral deposits and rusty color; OR = 1.32, 95% CI = 1.12, 1.56), use of alternatives to home tap water (OR = 1.25, 95% CI = 1.04, 1.51), and with decreased water quality and acceptability (OR = 1.21, 95% CI = 1.01, 1.45; P &lt; 0.05). The odds of mistrusting tap water were significantly lower for those whose primary source of drinking water is the public supply (municipal) (OR = 0.07, 95% CI = 0.01, 0.63) and with decreased water access (OR = 0.56, 95% CI = 0.48, 0.66; P &lt; 0.05). Latinx mistrust of tap water appears to be associated with organoleptic perceptions and reliance on alternatives to the home drinking water system.
Novel Concepts in the Management of Angina in Coronary Artery Disease
Authors: Theofilis Panagiotis , Oikonomou Evangelos , Sagris Marios , Papageorgiou Nikolaos , Tsioufis Konstantinos , Tousoulis Dimitris 
Published: May 2023

Abstract:Coronary artery disease remains a condition with high prevalence and detrimental effects on the quality of life of affected individuals. Its most frequent manifestation, stable angina pectoris, may be challenging to manage despite the available antianginal pharmacotherapy and adequate risk factor control, especially in subjects not amenable to revascularization. In the direction of refractory angina pectoris, several approaches have been developed over the years with varying degrees of success. Among the most recognized techniques in managing angina is enhanced external counterpulsation, which utilizes mechanical compression of the lower extremities to increase blood flow to the heart. Moving to coronary sinus reduction, it leads to an increase in coronary sinus backward pressure, ultimately augmenting myocardial blood flow redistribution to ischemic regions and ameliorating chronic angina. Clinical trial results of the above-mentioned techniques have been encouraging but are based on small sample sizes to justify their widespread application. Other interventional approaches, such as transmyocardial laser revascularization, extracorporeal shockwave myocardial revascularization, and spinal cord stimulation, have been met with either controversial or negative results, and their use is not recommended. Lastly, angiogenic therapy with targeted intramyocardial vascular endothelial growth factor injection or CD34+ cell therapy may be beneficial and warrants further investigation. In this review, we summarize the current knowledge in the field of angina management, highlighting the potential and the gaps in the existing evidence that ought to be addressed in future larger-scale, randomized studies before these techniques can be safely adapted in the clinical practice of patients with refractory angina pectoris.
Synthetic Approaches Towards Taxol; from Holton to Chida
Authors: Elmansy Mohamed F. , Borik Rita M. , Khidre Rizk E. 
Published: May 2023

Abstract:
Nature is an inspiring source in drug discovery which constantly reveals new complex
chemical structures of natural products that inherit attractive chemical challenges for
organic chemists to synthesize them. Taxol is a unique natural product that impressive biological
properties and a very tempting chemical structure that motivated organic chemists all
over the world to enter the race for synthesizing it. The total synthesis of this highly oxygenated
diterpene was completed by 11 different research groups starting from Holton (1994) to
Chida (2022). This review article demonstrates the various retrosynthetic analysis of Taxol,
the actual synthetic routes to it and highlights the key steps in each synthesis. It also provides
a critical review of the advantages and disadvantages in all the synthetic routes in terms of
number of steps, yields and the synthetic challenges.
Treatment of Parkinson's Disease: Current Treatments and Recent
Therapeutic Developments
Authors: Wal Ankita , Wal Pranay , Vig Himangi , Jain Nem Kumar , Rathore Shruti , Krishnan Karthickeyan , Srivastava Ashish 
Published: May 2023

Background:
Parkinson’s disease (PD) is a neurodegenerative syndrome defined by a variety
of motor, cognitive, and psychomotor dysfunctions. The current pharmaceutical treatment focuses
on treating the condition's symptoms. They are primarily concerned with reducing illness symptoms or
avoiding dopamine metabolism. As our understanding of disease pathogenesis improves, new therapeutic
approaches emerge.

Objective:
This article aims to describe the standard Parkinson's medications based on symptoms and
requirements. It emphasizes recent advancements in symptomatic therapy for motor indications and
achievements in the research and clinical testing of medicines that promise to enable disease modification
in patients with already-manifest PD.

Methods:
Information for this paper was found by looking through Google Scholar and reading several
research and review articles from Bentham Science, Science Direct, Elsevier, Frontiers, Taylor &
Francis, and other publishers.

Result:
Parkinson's disease therapeutic interventions are now limited to symptomatic therapy, mostly
in dopaminergic medications and deep brain stimulation (DBS). They have the potential to deliver
great therapeutic progress, yet they can also have serious drawbacks that decrease a patient's quality of
life. The progress of pluripotent stem cell therapies and genome engineering procedures has sparked
renewed hope for the treatment of a wide range of human illnesses, particularly genetic abnormalities.

Conclusion:
The current Parkinson's therapy trends are successful and continually evolving, with several
drugs currently undergoing clinical trials. As these new therapies constantly coming out and can
be used together, they will likely change how Parkinson's disease is treated in the coming years.
Physeal Sparing Proximal Femoral Endoprosthetic Reconstruction with a Short Distal Segment: A Case Report
Authors: Galanter Eytan , Damron Timothy A. 
Published: May 2023

Background:
A custom endoprosthesis allowed for the preservation of the distal femoral physis with a short remaining metaphyseal segment after osteosarcoma resection in a 10-year-old boy. CASE

Case Presentation:
This case illustrates a reconstructive alternative allowing physeal sparing with minimal remaining metaphyseal bone. At the three-year follow-up, the patient has remained complication-free with distal femoral growth maintaining symmetric limb length.

Conclusion:
When intercalary biologic reconstruction is not an option and the sacrifice of physis necessitates an extendible total femoral prosthesis, custom physeal sparing short segment press-fit fixation is an appropriate solution.
Pengembangan Aplikasi Helpdesk Ticketing System Dengan Algoritma Multinomial Naïve Bayes Classifier
Authors: Setiawan Muhammad Dery , Eliyani Eliyani 
Published: May 2023

PT FGS Infotama merupakan perusahaan penyedia jasa Aplikasi Online Trading yang tidak hanya fokus pada implementasi tahap awal, melainkan beberapa hal penting lainnya, seperti pelatihan, pengembangan, perawatan dan sosialisasi terkait dengan software yang diterapkan. Saat ini keluhan diterima melalui email, telepon maupun whatsapp sehingga relatif sulit dalam mengelola keluhan yang masuk. Tujuan dari penelitian ini adalah membuat helpdesk ticketing system yang dilengkapi dengan klasifikasi tingkat urgensi keluhan, dan beberapa fitur lain seperti Frequently Asked Question, News yang berisi infomasi ke klien dari Perusahaan, dan Notifikasi tiket masuk dan ketika tiket telah diselesaikan. Metode yang digunakan untuk mengembangkan aplikasi ini adalah metode Waterfall, sementara algoritma yang digunakan untuk mengklasifikasi keluhan adalah Multinomial Naive Bayes Classifier. Algoritma ini diimplementasikan pada form create ticket. Aplikasi dikembangkan berbasis web. Setelah dilakukan pengujian, didapatkan hasil akurasi data yang berasal dari email sebesar 61.90% dan hasil akurasi dari data yang berasal dari whatsapp sebesar 73.6%.