bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tracing Founder Mutations in Circulating and Tissue-Resident Follicular Lymphoma Precursors
Authors: Schroers-Martin Joseph G. , Soo Joanne , Brisou Gabriel , Scherer Florian , Kurtz David M. , Sworder Brian J. , Khodadoust Michael S. , Jin Michael C. , Bru Agnès , Liu Chih Long , Stehr Henning , Vineis Paolo ,   for the EPIC Consortium, Natkunam Yasodha , Teras Lauren R. , Song Joo Y. , Nadel Bertrand , Diehn Maximilian , Roulland Sandrine , Alizadeh Ash A. 
Published: March 2023

Abstract

Follicular lymphomas (FL) are characterized by BCL2 translocations, often detectable in blood years before FL diagnosis, but also observed in aging healthy individuals, suggesting additional lesions are required for lymphomagenesis. We directly characterized early cooperating mutations by ultradeep sequencing of prediagnostic blood and tissue specimens from 48 subjects who ultimately developed FL. Strikingly, CREBBP lysine acetyltransferase (KAT) domain mutations were the most commonly observed precursor lesions, and largely distinguished patients developing FL (14/48, 29%) from healthy adults with or without detected BCL2 rearrangements (0/13, P = 0.03 and 0/20, P = 0.007, respectively). CREBBP variants were detectable a median of 5.8 years before FL diagnosis, were clonally selected in FL tumors, and appeared restricted to the committed B-cell lineage. These results suggest that mutations affecting the CREBBP KAT domain are common lesions in FL cancer precursor cells (CPC), with the potential for discriminating subjects at risk of developing FL or monitoring residual disease.

Significance:
Our study provides direct evidence for recurrent genetic aberrations preceding FL diagnosis, revealing the combination of BCL2 translocation with CREBBP KAT domain mutations as characteristic committed lesions of FL CPCs. Such prediagnostic mutations are detectable years before clinical diagnosis and may help discriminate individuals at risk for lymphoma development.
This article is highlighted in the In This Issue feature, p. 1275
Effect of Cyclooxygenase Inhibition on Peripheral Venous Distension Reflex in Healthy Humans
Authors: Hamaoka Takuto , Leuenberger Urs A. , Kronfli Anthony , Gao Zhaohui , Blaha Cheryl , Carter Luck Jonathan , Dalton Paul , Sinoway Lawrence I. , Cui Jian 
Published: March 2023

Background:
Peripheral venous distension evokes a pressor reflex (venous distension reflex). Afferent group III and IV nerves innervating veins are suggested as the afferent arm of the venous distension reflex. Prostaglandins stimulate/sensitize group III/IV nerves. We hypothesized that inhibition of prostaglandin synthesis by local cyclooxygenase blockade would attenuate the muscle sympathetic nerve activity (MSNA) and blood pressure responses to venous distension.

Methods:
Nineteen healthy volunteers (age, 27±5 years) participated in the study with 2 visits. To induce venous distension, a volume of solution (saline alone or 9 mg ketorolac tromethamine in saline) was infused into the vein in the antecubital fossa of an arterially occluded forearm. During the procedure, beat-by-beat heart rate, blood pressure and MSNA were recorded simultaneously. The vein size was measured with ultrasound.

Results:

In both visits, the venous distension procedure significantly increased blood pressure, heart rate, and MSNA (all,
P
<0.05). The increase in mean arterial pressure and MSNA in the ketorolac visit was significantly lower than in the control visit (∆ mean arterial pressure, 7.0±6.2 versus 13.8±7.7 mm Hg; ∆MSNA, 6.0±7.1 versus 14.8±7.7 bursts/min; both,
P
<0.05). The increase in vein size induced by the infusion was not different between visits.

Conclusions:
The presented data show that cyclooxygenase blockade attenuates the responses in MSNA and blood pressure to peripheral venous distension reflex. The results suggest that cyclooxygenase products play a key role in evoking afferent activation responsible for the venous distension reflex.
Genetic Susceptibility to Mood Disorders and Risk of Stroke: A Polygenic Risk Score and Mendelian Randomization Study
Authors: Sun Jiangming , Borné Yan , Edsfeldt Andreas , Wang Yunpeng , Pan Mengyu , Melander Olle , Engström Gunnar , Gonçalves Isabel , Abecasis Goncalo , Baras Aris , Cantor Michael , Coppola Giovanni , Economides Aris , Lotta Luca A. , Overton John D. , Reid Jeffrey G. , Shuldiner Alan , Beechert Christina , Forsythe Caitlin , Fuller Erin D. , Gu Zhenhua , Lattari Michael , Lopez Alexander , Overton John D. , Schleicher Thomas D. , Padilla Maria Sotiropoulos , Toledo Karina , Widom Louis , Wolf Sarah E. , Pradhan Manasi , Manoochehri Kia , Ulloa Ricardo H. , Bai Xiaodong , Balasubramanian Suganthi , Barnard Leland , Blumenfeld Andrew , Eom Gisu , Habegger Lukas , Hahn Young , Hawes Alicia , Khalid Shareef , Reid Jeffrey G. , Maxwell Evan K. , Salerno William , Staples Jeffrey C. , Yadav Ashish , Jones Marcus B. , Mitnaul Lyndon J. 
Published: March 2023

Background:
Mood disorders and strokes are often comorbid, and their health toll worldwide is huge. This study characterizes prognostic and causal roles of mood disorders in stroke.

Methods:
We tested if genetic susceptibilities for mood disorders were associated with all strokes, ischemic strokes in the Malmö Diet and Cancer cohort (24 631 individuals with a median follow-up of 21.3 (interquartile range: 16.6–23.2) years. We further examined the causal effects for mood disorders on all strokes and ischemic strokes using summary statistics from large genome-wide association studies of mood disorders (up to 609 424 individuals, Psychiatric Genomics Consortium), all strokes and ischemic strokes (up to 446 696 individuals, MEGASTROKE Consortium).

Results:
Among 24 366 stroke-free participants at baseline, 2632 individuals developed strokes, 2172 of them ischemic, during follow-up. After properly adjusting for well-known risk factors, participants in the highest quintile of polygenic risk scores for mood disorders had 1.45× (95% CI, 1.21–1.74) higher risk of strokes and 1.44× (95% CI, 1.18–1.76) higher risk of ischemic strokes compared with the lowest quintile in women. Mendelian randomization analyses suggested that mood disorders had a causal effect on strokes (odds ratio, 1.07 [95% CI, 1.03–1.11]) and ischemic strokes (odds ratio, 1.09 [95% CI, 1.04–1.13]).

Conclusions:
Our results suggest a causal role of mood disorders in the risk of stroke. High-risk women could be identified early in life using polygenic risk scores to ultimately prevent mood disorders and strokes.
Number Needing Review: A Novel Metric to Assess Triage Efficiency of Large Vessel Occlusion Detection Systems
Authors: Catapano Joshua S. , Lee Katriel E. , Desai Shashvat M. , Rangel India C. , Stonnington Henry O. , Rumalla Kavelin , Rutledge Caleb , Srinivasan Visish M. , Baranoski Jacob F. , Cole Tyler S. , Winkler Ethan A. , Ducruet Andrew F. , Albuquerque Felipe C. , Jadhav Ashutosh P. 
Published: March 2023

Background
Endovascular thrombectomy is the gold‐standard treatment for large vessel occlusions (LVOs). A novel metric is introduced: the number needing review (NNR) to assess the triage efficiency of LVO detection systems.

Methods
Patients with suspected ischemic stroke and images processed by RapidAI LVO detection software over 6 months were reviewed. Only patients with LVOs of the M1 segment were included. The NNR was calculated for an M1 occlusion.

Results

Of 559 patients, M1 occlusion was detected in 42 patients (7.5%). RapidAI LVO had a sensitivity of 71%, specificity of 94%, positive predictive value of 49%, and negative predictive value of 92% for M1 occlusion. When gaze deviation and hyperdense sign were combined with RapidAI LVO, the specificity and positive predictive value increased to 100% for an M1 occlusion. A negative RapidAI LVO result combined with a low (<15 mL, T
max
>6 seconds) or high (<50 mL, T
max
>6 seconds) T
max
threshold was found to have a specificity and positive predictive value of 100% for no occlusion. The combination of gaze deviation, hyperdense sign, positive RapidAI LVO, and negative RapidAI LVO with low T
max
threshold yielded an NNR of 24 per 100 cases. When combined with a negative RapidAI LVO and a high T
max
threshold, the NNR was 16 per 100 cases. Adding National Institutes of Health Stroke Scale score <7 decreased the NNR to 9 per 100 cases.

Conclusion

Adding gaze deviation and hyperdense sign to the RapidAI LVO increases the specificity and positive predictive value for an M1 occlusion. When combined with a negative RapidAI LVO detection and either a low or high T
max
>6 seconds threshold, the NNR is significantly reduced.
Salafi-Jihadi Online Communication in Israel: Forging a Community Through an “Enclave” Mindset
Authors: Alshech Eli 
Published: March 2023

Abstract
The article explores the ways in which online posting by contemporary Salafi-jihadis in Israel create an enclave mentality that serves to transform Salafi-jihadis into an insular community. Because Salafi-jihadis can no longer by law advocate active jihad on social media in Israel, their posts focus on three Islamic legal themes: The dichotomy between God’s devotees and God’s enemies; the untrustworthiness of Muslim rulers, official Muslim scholars, and “impious” Muslim associations like the Muslim Brothers; and the obligation to apply the doctrine of takfīr against Muslims and deviant Muslim rulers. Although seemingly innocuous, social media posts encourage Salafi-jihadis to take actions that result in their segregation from other Muslims in Israel, particularly Salafi-Taqlidis, and, at the same time, create and maintain a networked community of like-minded individuals willing to implement the Salafi-jihadi creed when the time is ripe.
Interviewing Animals Through Animal Communicators
Authors: Wijngaarden Vanessa 
Published: March 2023

Abstract
Animal communicators worldwide employ intuitive interspecies communication (IIC) to engage in detailed, two-way communication with nonhuman animals. IIC’s potential for doing research with rather than on animals has been insufficiently explored, due to contingent onto-epistemological biases. Cooperating with animal communicators as interpreters, pilot interviews with felines were conducted. Challenges included clearly filtering the animals’ voices and bridging ontological divides and communication modes. Nevertheless, the interviews produced clear, distinct, and consistent responses, challenging and confronting both animal communicators and the researcher to reflect on their perspectives, expectations and assumptions. Engaging animals as research participants through IIC simultaneously unsettles hierarchical divides between humans and other animals, as well as between different ways of knowing. IIC can support researchers and (non)human participants in the co-creation of novel methodological multispecies strategies that form a practical counterpart to the largely theoretical explorations of the ontological and species turns, and further multivocality in academia.
Pandemic Capitalism: Metabolic Rift, World-Ecology Crossing Dialectical Biology
Authors: Bergamo Jacopo Nicola 
Published: March 2023

Abstract
In this article, I contrast two of the main schools of thought within eco-Marxism, namely Metabolic Rift (MR) and World-Ecology (WE). These differ above all else in their accounts of the ontological status of society and nature. The Covid-19 pandemic constitutes a moment of concretisation of this long-standing debate, which is able to dissolve at least in part its issues. The article consists of four parts. I begin with a summary of the two schools of thought and their core stances, before proceeding to unpack their respective theoretical points of contention. I subsequently proceed to explore the conceptualisation of health according to the Marxist scientists Richard Levins and Richard Lewontin through the model of dialectical biology. In the third section, I unpack the conceptualisation of the Covid-19 pandemic by the epidemiologist Robert Wallace, before finally concluding with the contrasts of the two schools in the light of dialectical biology.
Tradition as Body
Authors: Nikkel David H. 
Published: March 2023

Abstract
Coming from the perspective of embodied or enactive cognition, this article argues for the bodily roots of all tradition. Given that tradition entails a givenness inherited from the past meeting with interpretation/modification/construction in the present, it examines tradition as an aspect of self-organizing cultural, particularly religious, systems, including in situations far from equilibrium. Building upon Michael Polanyi’s idea that what we tacitly rely upon becomes incorporated into our bodies, the article takes a phenomenological approach to argue that traditions function as part of our bodies through which we meaningfully engage the world. As such, tradition sets limits to our critical penetration, as much of our knowledge is unspecifiable. The Enlightenment ideal that all tradition is thoroughly contestable – open to explicitation and needing justification – remains strong in the academy. The article examines both the pitfalls of critical reflection and when critical reflection is appropriate or necessary.
Effect of host plants on the biology and nutritional indices of fall armyworm, Spodoptera frugiperda (J.E. Smith) (Lepidoptera: Noctuidae)
Authors: Nandhini D. , Deshmukh Sharanabasappa S. , Kalleshwaraswamy C.M. , Satish K.M. , Sannathimmappa H.G. 
Published: March 2023

Abstract
The biology of the fall armyworm (FAW), Spodoptera frugiperda (J.E. Smith, 1797) (Lepidoptera: Noctuidae), on various plant parts was studied under laboratory conditions. The hosts used were maize cob, maize leaves, sorghum leaves, cowpea leaves, castor leaves, banana leaves and marigold flowers. Differences were observed across the hosts with respect to the growth and development of FAW. The shortest larval duration was found in larvae that consumed maize cob, but marigold flowers increased the larval duration. The pupal duration did not differ between hosts, but the pupal weight was greatest when reared on castor leaves. Fecundity, hatchability and survivability were recorded highest when reared on maize leaves, followed by maize cob. Therefore, maize cob was the best suited host of FAW, helping in the completion of the life cycle within a short duration with higher fecundity.
Finnish Confirmation Training in Religious Biographies
Authors: Toivanen Heidi 
Published: March 2023

Abstract
Several recent studies have examined religious biographies, i.e. individual religious trajectories. However, little research has been conducted on the relevance of single life events in religious biographies, such as religious rites of passage. One such rite of passage, confirmation training, has preserved its popularity in Finland despite declining church membership. The aim of this study, therefore, was to examine the relevance of Finnish confirmation training in religious biographies. The data comprise 15 multigenerational family interviews (N = 54) conducted in 2019–2022. The study is part of an international research investigating religious transmission over generations. The findings indicate that confirmation training initiates a socialization process in relation to areas of faith, religious community, family heritage and cultural heritage. These relations comprise three types of movement: attachment, distancing, and stability/ irrelevance. The results demonstrate the complexity and uniqueness of religious biographies as individuals create distinctive religious trajectories and transitions.
Monetized Religion in the Public Church
Authors: Roleder Felix 
Published: March 2023

Abstract
The quantitative study undertakes a systematic investigation of the church-related donation practice in the context of the Protestant Church in Germany. The characteristic logics of membership and participation in this publicly regulated institutionalized church are considered as well as the multidimensionality of donation practice. Religious donations are located at the interface of the individual and the church institution. Key explanatory factors for financial giving emerge: objective and subjective costs, opportunities and occasions, institutional identification and reputation, social context, prayer practice, competition, and mediatized publics. Rational choice, generalized reciprocity, and risk and trust calculations act as guiding theories. The empirical findings are connected to a general theory of religious behavior. Implications for church fundraising, church financing, and church membership are discussed.
Benefits and Challenges of Institutionalizing Peacebuilding and Activism in a Post-Liberal World
Authors: Bath Clare , Gamaghelyan Philip 
Published: March 2023

Abstract
Peace and conflict studies is a normative field that seeks to reduce or eradicate violence. With multiple forms of violence plaguing human society, institutionalization of civil society has long been a tenet of liberal approaches to peace intended to enhance sustainability and policy impact of activism. Along with benefits, however, institutionalization brought with it a set of challenges, including cooptation by donors and competition among activists. The article builds on the analysis of 14 in-depth interviews, insights gathered from the “Rethinking Peace” workshop conducted in Mtsheka, Georgia in July 2022, and desk research on the risks and benefits of institutionalization of activism in the context of peacebuilding in the South Caucasus and the civil rights movement in the United States. Despite clear contextual differences and varying degrees of commitment to liberal and post-liberal approaches to peace, the article highlights striking similarities when it comes to benefits and challenges of institutionalization.
Combating Illegal, Unreported, and Unregulated Fishing: A Vietnamese Perspective
Authors: Ho Ai Nhan , Ngo Phuoc Huu 
Published: March 2023

Abstract
This article discusses Vietnam’s efforts to combat illegal, unreported and unregulated (IUU) fishing and future possibilities, including an analysis of the various drivers and causes of IUU fishing in the country. While Vietnam’s efforts and determination in the fight against IUU fishing have been promoted since 2017 when the European Commission imposed a ‘yellow card’ on Vietnam’s fishing industry, the outcome has not been as expected. Among the measures proposed to improve the effectiveness of combating IUU fishing in Vietnam, the focus has been on strengthening the national legal framework. These measures include (i) drafting a law on fishing at sea; (ii) developing a code of responsible fisheries; (iii) amending the penal code to criminalise acts of IUU fishing; and (iv) increasing sanctions for IUU fishing violations. In addition, strengthening law enforcement is discussed as a necessary tool to effectively address IUU fishing in Vietnam.
Jurisprudential Developments and Adjudication of Indigenous Peoples’ Rights
Authors: Fuentes Alejandro 
Published: March 2023

Abstract
In recent years, the Inter-American Court of Human Rights (“IACrtHR”) has developed an innovative jurisprudence that has reaffirmed and further developed the right of indigenous peoples as an integrative part of the corpus juris of the international human rights law (“ihrl”). In fact, through a dynamic, systemic, evolutive and effective interpretation of the American Convention on Human Rights (“achr”), the regional tribunal has expanded the scope of protection of Article 21 achr (Right to Property) in a manner that includes the protection of the special relationship that indigenous peoples have with their traditional lands, territories and natural resources.
Based on this interpretative development, the IACrtHR has further expanded the protection of indigenous peoples’ communal property to guarantee their right to cultural identity and to a dignified life, that is, to live in accordance with their own cultural traditions and understanding of dignity. In this sense, specific safeguards against unjustified restrictions on the right to property, that could amount to a denial of the cultural survival of indigenous peoples, were jurisprudentially identified by the regional tribunal.
This paper critically analyses the legal regime applicable for the protection of the right to traditional communal property of indigenous and tribal peoples in the Americas, as developed by the IACrtHR. In particular, it pays special attention to the methods of interpretation applied by the regional tribunal and the manner that has referred to the corpus juris of international human rights law that specifically protects and guarantees the rights of indigenous peoples.
The Rights of Minority Nationalities Under State Constitutions
Authors: Woldegiorgies Leul 
Published: March 2023

Abstract
The purpose of this article is to examine the rights of Minority Nationalities under state constitutions in the case of Amhara Regional constitution. Hence, a qualitative research approach focusing on phenomenological design was employed. Participants of the study were twenty. They were selected through purposive sampling technique. Semi-structured interviews and document analysis were used to collect data for the study. An adapted five-stage data analysis model was also used to analyze the data. The findings of the study revealed that some minorities living in the region did not have a legitimate political representation in the regional government. Lack of government’s responsiveness and lack of commitment were the main challenges that intervene in the process of implementing the constitutional rights given for the minorities. Towards the end of this article, the implications of these findings for implementing the constitutional provisions of the minority rights, and establishing an institution has been highlighted
Tacit Choice of Law Applicable to International Commercial Contracts: The Hague Principles and Arab Laws Compared
Authors: Dawwas Amin 
Published: March 2023

Abstract
This article deals with the law tacitly chosen by the parties to govern their international commercial contracts. It shows the method by which The 2015 Hague Principles on Choice of Law in International Commercial Contracts and Arab laws refer to tacit choice, whether directly or indirectly. In addition, it tackles the level of strictness in tests for tacit choice and its criteria under both The Hague Principles and Arab laws. It concludes that, in order to achieve more predictability and legal certainty, the Legislatures in Arab states should reform the legal provisions on choice of law applicable to the contract with foreign element(s) according to the best practice followed by The Hague Principles in this regard.
Globalisation and Its Challenges: Reflections on Social Order and Chaos through the Prism of Social Nomos-Anomie Concept
Authors: Niboye Elliott P. 
Published: March 2023

Abstract
Anomic situations in societies are often brought about by social changes. Social anomie is a phenomenon that emerges when traditional norms are not sufficient enough to adequately respond to the new emerging situations, although this does not necessarily imply a state of normlessness in a society. These emerging new situations might result from society’s internal development processes or can be externally imposed. The process of globalisation has brought many major changes in the world political and social-cultural systems. The hitherto unprecedented flow of capital in the name of globalisation has led to a more stratified world than it was before. This process, mainly driven by economic rationalities, has led to social, cultural, environmental and political instabilities in many societies around the world. In a world that lacks a real-world social order, this article reflects on how globalisation impacts on social systems and proposes a spaceship ethic value orientation in charting out ways towards reaching the new world order, where every society can be an indispensable part of the world nomos.