bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative Efficacy of Selected Chemicals and Neem Oil against Okra Shoot and Fruit Borer [Earias vittella (Fabricius)] on Okra
Authors: Devi M. Jahnavi Eshwari , Tayde Anoorag R. , Herald Kadathatla Persis 
Published: August 2023

The field investigation was carried out in Kharif season of 2022 at Central Research Farm (CRF), Sam Higginbottom University of Agriculture, Technology and Sciences, Prayagraj, Uttar Pradesh, India. The experiment was laid in Randomized Block Design with eight treatments each replicated thrice viz., Emamectin benzoate 5% SG (5 g/lit), Lambda cyhalothrin 2.5% EC (0.5-1 ml/lit), Flubendiamide 480 SC (0.3 ml/lit), Imidacloprid 17.8% SL (1 ml/2.5 lit), Chlorantraniliprole 18.5% SC (0.5 ml/lit), Neem oil @2% (20 ml/lit), Spinosad 45% SC (0.3-0.4 ml/lit), and control plot. The result revealed that among all the treatments lowest percent shoot infestation and fruit infestation of okra shoot and fruit borer was recorded in Chlorantraniliprole 18.5% SC (13.90%), (13.11%) at both sprayers followed by Spinosad 45% SC (15.89%), (14.25%), Emamectin benzoate 5% SG (16.59%), (15.02%), Flubendiamide 480 SC (17.27%), (15.30%), Imidacloprid 17.8% SL (17.44%), (16.63%), Lambda cyhalothrin 2.5% EC (19.09%), (16.97%), Neem oil @2% (19.21%), (17.23%) and Control (30.87%), (25.44%). The highest yield and cost benefit ratio was recorded in Chlorantraniliprole 18.5% SC (158.33 q/ha), (1:6.1) followed by Spinosad 45% SC (153.33 q/ha), (1:5.4), Emamectin benzoate 5% SG (133.33 q/ha), (1:5.3), Flubendiamide 480 SC (116.66 q/ha), (1:4.7), Imidacloprid 17.8% SL (105 q/ha), (1:4.2), Lambda cyhalothrin 2.5% EC (83.33 q/ha), (1:3.3), Neem oil @2% (70 q/ha), (1:2.8) and Control plot (33.33 q/ha), (1:1.3).
Accumulation of TERT in mitochondria exerts two opposing effects on apoptosis
Authors: Ebata Hiroshi , Shima Tomohiro , Iizuka Ryo , Uemura Sotaro 
Published: August 2023

Telomerase reverse transcriptase (TERT) is a protein that catalyzes the reverse transcription of telomere elongation. TERT is also expected to play a non‐canonical role beyond telomere lengthening since it localizes not only in the nucleus but also in mitochondria, where telomeres do not exist. Several studies have reported that mitochondrial TERT regulates apoptosis induced by oxidative stress. However, there is still some controversy as to whether mitochondrial TERT promotes or inhibits apoptosis, mainly due to the lack of information on changes in TERT distribution in individual cells over time. Here, we simultaneously detected apoptosis and TERT localization after oxidative stress in individual HeLa cells by live‐cell tracking. Single‐cell tracking revealed that the stress‐induced accumulation of TERT in mitochondria caused apoptosis, but that accumulation increased over time until cell death. The results suggest a new model in which mitochondrial TERT has two opposing effects at different stages of apoptosis: it predetermines apoptosis at the first stage of cell‐fate determination, but also delays apoptosis at the second stage. As such, our data support a model that integrates the two opposing hypotheses on mitochondrial TERT's effect on apoptosis. Furthermore, detailed statistical analysis of TERT mutations, which have been predicted to inhibit TERT transport to mitochondria, revealed that these mutations suppress apoptosis independent of mitochondrial localization of TERT. Together, these results imply that the non‐canonical functions of TERT affect a wide range of mitochondria‐dependent and mitochondria‐independent apoptosis pathways.
A Fluorescent Chemosensor for Long‐Term Tracking of Cancer Cell Metastasis and Invasion via Enzyme‐Activated Anchoring
Authors: Liu Ting , Xia Xiang , Wang Ran , Rong Xiang , Su Zehou , Du Jianjun , Fan Jiangli , Peng Xiaojun , Sun Wen 
Published: August 2023

AbstractEvidence shows that the enzyme human cytochrome P450 1A1 (CYP1A1) is associated with cancer; indeed, it is shown to play a key role in the occurrence of many cancers. Therefore, the molecular imaging of CYP1A1 in cells is of great significance for revealing the process of cancer development. Herein, a chemosensor, DCBEM, is reported that is able to selectively recognize CYP1A1 and achieve long‐term labeling of the enzyme through an enzymolysis cascade reaction. The design of DCBEM relies on the reaction between the highly electrophilic intermediate (quinone methide) and the enzyme, which forms a fluorescent label with CYP1A1 via covalent bonding. The chemosensor reveals excellent specificity toward CYP1A1 and achieves high‐resolution monitoring of cell migration with a strong retention capacity in vivo (up to 4 days). Further, using DCBEM, the pathways of invasion of colon cancer and breast cancer cells are successfully visualized in living mice. This method of labeling enzymes provides a simple and efficient way to render ordinary fluorescent chemosensors suitable for the long‐term tracking of cancer cells, for which such molecular tools are currently lacking.
J‐Aggregation Strategy toward Potentiated NIR‐II Fluorescence Bioimaging of Molecular Fluorophores
Authors: Hu Xiaoming , Zhu Caijun , Sun Fengwei , Chen Zejing , Zou Jianhua , Chen Xiaoyuan , Yang Zhen 
Published: August 2023

AbstractMolecular fluorophores emitting in the second near‐infrared (NIR‐II, 1000–1700 nm) window with strong optical harvesting and high quantum yields hold great potential for in vivo deep‐tissue bioimaging and high‐resolution biosensing. Recently, J‐aggregates are harnessed to engineer long‐wavelength NIR‐II emitters and show unique superiority in tumor detection, vessel mapping, surgical navigation, and phototheranostics due to their bathochromic‐shifted optical bands in the required slip‐stacked arrangement aggregation state. However, despite the preliminary progress of NIR‐II J‐aggregates and theoretical study of structure‐property relationships, further paradigms of NIR‐II J‐aggregates remain scarce due to the lack of study on aggregated fluorophores with slip‐stacked fashion. In this effort, how to utilize the specific molecular structure to form slip‐stacked packing motifs with J‐type aggregated exciton coupling is emphatically elucidated. First, several molecular regulating strategies to achieve NIR‐II J‐aggregates containing intermolecular interactions and external conditions are positively summarized and deeply analyzed. Then, the recent reports on J‐aggregates for NIR‐II bioimaging and theranostics are systematically summarized to provide a clear reference and direction for promoting the development of NIR‐II organic fluorophores. Eventually, the prospective efforts on ameliorating and promoting NIR‐II J‐aggregates to further clinical practices are outlined.
A Nanoscale Ternary Amide‐rGO Composite with Boosted Kinetics for Reversible H2 Storage
Authors: Dun Chaochao , Li Sichi , Chen Linfeng , Horton Robert D. , Allendorf Mark D. , Wood Brandon C. , Stavila Vitalie , Urban Jeffrey J. 
Published: August 2023

AbstractMetal amides are attractive candidates for hydrogen storage due to their high volumetric and gravimetric hydrogen densities. However, the sluggish kinetics and competing side reactions during hydrogen uptake and release limit their practical use. Here, a novel nanoconfined Li2Mg(NH)2@reduced graphene oxide (rGO) composite is presented, which is fabricated using a melt‐infiltration method with a minimum weight penalty of only 2 wt.%. The presence of rGO ensures close contact between the active phases, effectively preventing aggregation during cycling process. As a result, the reversible capacity of Li2Mg(NH)2@rGO reaches 4.42 wt.%, with no capacity degradation observed after multiple cycling. Theoretical calculations show that rGO catalyzes the hydrogen bond cleavage at the Mg‐amide/Li hydride interface, leading to local dehydrogenation hotspots and significantly improves kinetics of dehydrogenation compared to the bulk counterpart. This study provides a promising strategy for designing metal imide‐based composites to overcome the kinetic limitations and improve their reversible hydrogen storage performance.
Targeting Alpha‐Ketoglutarate Disruption Overcomes Immunoevasion and Improves PD‐1 Blockade Immunotherapy in Renal Cell Carcinoma
Authors: Li Le , Zeng Xing , Chao Zheng , Luo Jing , Guan Wei , Zhang Qiang , Ge Yue , Wang Yanan , Xiong Zezhong , Ma Sheng , Zhou Qiang , Zhang Junbiao , Tian Jihua , Horne David , Yuh Bertram , Hu Zhiquan , Wei Gong‐Hong , Wang Baojun , Zhang Xu , Lan Peixiang , Wang Zhihua 
Published: August 2023

AbstractThe Warburg effect‐related metabolic dysfunction of the tricarboxylic acid (TCA) cycle has emerged as a hallmark of various solid tumors, particularly renal cell carcinoma (RCC). RCC is characterized by high immune infiltration and thus recommended for immunotherapeutic interventions at an advanced stage in clinical guidelines. Nevertheless, limited benefits of immunotherapy have prompted investigations into underlying mechanisms, leading to the proposal of metabolic dysregulation‐induced immunoevasion as a crucial contributor. In this study, a significant decrease is found in the abundance of alpha‐ketoglutarate (αKG), a crucial intermediate metabolite in the TCA cycle, which is correlated with higher grades and a worse prognosis in clinical RCC samples. Elevated levels of αKG promote major histocompatibility complex‐I (MHC‐I) antigen processing and presentation, as well as the expression of β2‐microglobulin (B2M). While αKG modulates broad‐spectrum demethylation activities of histone, the transcriptional upregulation of B2M is dependent on the demethylation of H3K4me1 in its promoter region. Furthermore, the combination of αKG supplementation and PD‐1 blockade leads to improved therapeutic efficacy and prolongs survival in murine models when compared to monotherapy. Overall, the findings elucidate the mechanisms of immune evasion in anti‐tumor immunotherapies and suggest a potential combinatorial treatment strategy in RCC.
Carbonic anhydrase textile structured packing for efficient CO2 absorption in methyldiethanolamine solvent
Authors: Xiao Min , Thompson Jesse , Shen Jialong , Salmon Sonja , Liu Kunlei 
Published: August 2023

AbstractCarbonic anhydrase (CA) is an attractive biodegradable catalyst for CO2 absorption in solvent‐based CO2 capture. However, maintaining the stability of CA as a homogeneous component of the solvents is a challenge. Solvent regeneration temperature typically exceeds the enzyme thermal tolerance, which leads to CA deactivation. To reduce the need for frequent CA replenishment and to avoid inactive CA accumulation in the solvent, this work shows the benefits of an immobilization strategy where CA is fixed in a second‐generation design of textile structured packing (CATSP‐2) modules. The enzyme‐immobilized packing showed 1.5 times better performance in CO2 separation compared with traditional structured packing with a corresponding increased CO2 loading in the rich solvent. The modules exhibited good CA activity retention of ~80% during the tests without any CA replenishment. Applying CATSP‐2 could potentially decrease the packing height and absorber column size for a lower cost per amount of CO2 captured.
Synthesis of dodecylbenzene via the alkylation of benzene and 1‐dodecene over mesopore Beta zeolites
Authors: Liu Baoyu , Lu Weijian , Liu Yikuan , Feng Qilong , Huang Yi , Shang Jin , Zhu Yihan , Dong Jinxiang 
Published: August 2023

AbstractThe alkylation of benzene with long chain α‐olefins is a crucial process in the production of fine chemicals, which requires the upgrading from traditional homogeneous catalysis to heterogeneous catalysis involving zeolites. However, the application of zeolite catalysts has been limited by their fast deactivation due to constrained diffusion resulting from the sole micropores. To address this challenge, a desilication and secondary‐crystallization strategy has been employed to fabricate hierarchically structured mesoporous Beta zeolites. The resultant mesoporous Beta zeolites demonstrate excellent catalytic activity and stability in the alkylation of benzene with 1‐dodecene, arising from the exposed acid sites and enhanced internal diffusion. Importantly, the internal diffusion limitations for these mesopore Beta zeolites are negligible, which significantly extends their lifetime and improves their regeneration performance. To achieve these benefits, the degree of mesopores must be deliberately controlled. Overall, this approach provides a promising solution for achieving efficient and environmentally friendly alkylation processes.
Towards an ethical and legal framework in archeogenomics: A local case in the Atlantic coast of central Patagonia
Authors: Tamburrini Camila , Dahinten Silvia Lucrecia , Saihueque Rubén Ricardo Romero , Ávila‐Arcos María C. , Parolin María Laura 
Published: August 2023

AbstractEthical discussions around ancient DNA (aDNA) research predate the technological breakthroughs that led to the accelerated generation of ancient genomic data, revealing a long‐due need to address these aspects in the field. Given the diverse conflicts that genomics has raised towards the communities associated with the Non‐living Human Ancestors under study, it has been suggested that the ethical and legal implications of genetically studying present‐day and ancient human populations should be considered case‐by‐case. Nevertheless, the discussions have focused on US and European perspectives. To contribute from a local and Latin American position to the problem, we present the history of consensus and disagreement of the relationships between scientists and Indigenous communities of the Atlantic coast of the central Argentinian Patagonia. We describe how these relationships resulted in the approval of a groundbreaking provincial law that acknowledges the Indigenous community's right to be involved in decision‐making concerning their Ancestors. In addition, we emphasize how these established relationships allowed the development of aDNA studies. With this background, we address the main ethical concerns of genomic studies of Ancestors identified in the reference literature and commit to applying some of the recommendations suggested in those ethical guidelines. Then, we reflect on possible negative consequences of ongoing research and propose some suggestions based on personal experiences that will contribute to moving the ethical field towards a more contextualized science with a local perspective.
Intoxication with massive doses of amlodipine and candesartan requiring venoarterial extracorporeal membrane oxygenation
Authors: Yusuke Minagawa , Hidetoshi Yamana , Yusuke Tsutsumi , Koji Ishigami , Masahito Togo , Susumu Yasuda , Takayuki Ogura 
Published: August 2023

AbstractBackgroundCalcium channel blockers and angiotensin II receptor blockers are commonly prescribed to treat hypertension. Massive overdoses can cause both distributive and cardiogenic shock because of their effects on vascular smooth muscles and severe myocardial depression.Case PresentationWe present the case of a 46‐year‐old man who was brought to our emergency department after ingesting 1210 mg amlodipine and 936 mg candesartan. The patient's hemodynamic status deteriorated despite treatment with vasopressors, calcium gluconate, and hyperinsulinemia‐euglycemia therapy with mechanical ventilation. Venoarterial extracorporeal membrane oxygenation was initiated for refractory shock. The patient was weaned off extracorporeal membrane oxygenation on day 5 and discharged on day 18 of hospitalization.ConclusionWhen medical therapies are ineffective, aggressive venoarterial extracorporeal membrane oxygenation should be considered for the management of refractory shock in the setting of calcium channel blocker with angiotensin II receptor blocker overdose.
Cationic β‐Scission of C−H and C−C Bonds for Selective Dimerization and Subsequent Sulfur‐Free RAFT Polymerization of α‐Methylstyrene and Isobutylene
Authors: Tanimoto Takayuki , Uchiyama Mineto , Kamigaito Masami 
Published: August 2023

AbstractA series of exo‐olefin compounds ((CH3)2C(PhY)−CH2C(=CH2)PhY) were prepared by selective cationic dimerization of α‐methylstyrene (αMS) derivatives (CH2=C(CH3)PhY) with p‐toluenesulfonic acid (TsOH) via β‐C−H scission. They were subsequently used as reversible chain transfer agents for sulfur‐free cationic RAFT polymerization of αMS via β‐C−C scission in the presence of Lewis acid catalysts such as SnCl4. In particular, exo‐olefin compounds with electron‐donating substituents, such as a 4‐MeO group (Y) on the aromatic ring, worked as efficient cationic RAFT agents for αMS to produce poly(αMS) with controlled molecular weights and exo‐olefin terminals. Other exo‐olefin compounds (R−CH2C(=CH2)(4‐MeOPh)) with various R groups were prepared by different methods to examine the effects of R groups on the cationic RAFT polymerization. A sulfur‐free cationic RAFT polymerization also proceeded for isobutylene (IB) with the exo‐olefin αMS dimer ((CH3)2C(Ph)−CH2C(=CH2)Ph). Furthermore, telechelic poly(IB) with exo‐olefins at both terminals was obtained with a bifunctional RAFT agent containing two exo‐olefins. Finally, block copolymers of αMS and methyl methacrylate (MMA) were prepared via mechanistic transformation from cationic to radical RAFT polymerization using exo‐olefin terminals containing 4‐MeOPh groups as common sulfur‐free RAFT groups for both cationic and radical polymerizations.
Mechanistic Understanding of Oxidation of Tin‐based Perovskite Solar Cells and Mitigation Strategies
Authors: Zhang Zhihao , Huang Yuanfang , Jin Jialun , Jiang Yiting , Xu Yuliang , Zhu Jingwei , Zhao Dewei 
Published: August 2023

AbstractTin (Sn)‐based perovskites as the most promising absorber materials for lead‐free perovskite solar cells (PSCs) have achieved the record efficiency of over 14 %. Although suppressing the oxidation of Sn‐based perovskites is a frequently concerned topic for Sn‐based PSCs, many studies have given vague explanations and the mechanisms are still under debate. This is in principal due to the lack of an in‐depth understanding of various and complex intrinsic and extrinsic factors causing the oxidation process. In this context, we critically review the chemical mechanism of facile oxidation of Sn‐based perovskites and differentiate its detrimental effects at material‐ and device‐level. More importantly, we classify and introduce the intrinsic factors (raw materials and solvent of perovskite precursors) and extrinsic factors (exposure to neutral oxygen and superoxide) causing the oxidation with their corresponding anti‐oxidation improvement methods. The presented comprehensive understanding and prospect of the oxidation provide insightful guidance for suppressing the oxidation in Sn‐based PSCs “from the beginning to the end”.
Late Holocene technological provisioning at the Kings Table rockshelter, Blue Mountains, New South Wales, Australia
Authors: McLaren Andrew , Oakes Geordie 
Published: August 2023

ABSTRACTTechnological analysis of the late Holocene component of the stone artefact assemblage recovered from the Kings Table rockshelter in the Blue Mountains, west of Sydney, provides the basis for an assessment of the site's role in broader late Holocene settlement‐subsistence systems. Drawing on Kuhn's widely employed “provisioning model”, as well as Kelleher's general pre‐contact occupation model for the Blue Mountains National Park (BMNP), we argue that the Kings Table rockshelter functioned as a short‐term field camp for logistically‐organised hunter‐gatherers whose principal residential bases were located in “off‐mountains” contexts. It is argued that the late Holocene component of the Kings Table assemblage has a technological “signature” entirely consistent with individual provisioning. Aboriginal groups occupying this site over the course of the late Holocene employed a mobile toolkit whose lithic component was dominated by artefacts manufactured out of high‐quality, transported silicified tuff and incorporated both backed artefact‐bearing composite tools and hafted edge‐ground hatchets (axes) as key elements.
Effect of the zinc transporter ZupT on the virulence mechanisms of mesophilic Aeromonas salmonicida SRW‐OG1
Authors: Wang Jiajia , Li Qiu , Huang Lixing 
Published: August 2023

AbstractAs a typical psychrophilic bacterial pathogen, Aeromonas salmonicida causes furunculosis in wild and farmed freshwater and marine fish, leading to substantial economic losses in the global aquaculture industry. Previous studies have shown that A. salmonicida is unable to grow above 25°C, hence limiting its infection to cold‐water fish. However, we isolated A. salmonicida SRW‐OG1, a mesophilic pathogenic strain from the warm‐water fish Epinephelus coioides. Through RNA‐seq analysis, we observe significant upregulation of the zupT gene at 28°C. ZupT is a member of zinc‐regulated transporters and iron‐regulated transporter‐like proteins (ZIP family) and is closely associated with transcriptional regulation of virulence in certain pathogens. Consequently, our study aimed to examine the role of zupT during A. salmonicida SRW‐OG1 infection at high temperatures. Our findings demonstrate that the zupT‐RNAi strain exhibits severe growth restriction under limited Zn2+ and Fe2+ conditions. Notably, this strain shows significantly reduced mortality rates and colonization abilities. Moreover, its motility, biofilm formation, adhesion, and hemolytic activities are significantly diminished. Confocal laser scanning microscopy reveals earlier and accelerated biofilm dissociation in the zupT‐RNAi strain. Analysis of extracellular products at 36 h indicates a considerable reduction in relative extracellular protein content in the zupT‐RNAi strain. Taken together, our results highlight the vital role of the zupT gene in zinc transport and the fitness of A. salmonicida SRW‐OG1 within the host.
Prenatal depression and risk of child autism‐related traits among participants in the Environmental influences on Child Health Outcomes program
Authors: Avalos Lyndsay A. , Chandran Aruna , Churchill Marie L. , Gao Xingyu , Ames Jennifer L. , Nozadi Sara S. , Roubinov Danielle , Brennan Patricia A. , Bush Nicole R. , Camargo Carlos A. , Carroll Kecia N. , Cioffi Camille C. , Ferrara Assiamira , Goldson Brandon , Hedderson Monique M. , Hipwell Alison E. , Kerver Jean M. , O'Connor Thomas G. , Porucznik Christina A. , Shuffrey Lauren C. , Talavera‐Barber Maria M. , Wright Rosalind J. , Zhu Yeyi , Croen Lisa A. ,   Program Collaborators for Environmental influences on Child Health Outcomes
Published: August 2023

AbstractThis study evaluated the association between prenatal depression and offspring autism‐related traits. The sample comprised 33 prenatal/pediatric cohorts participating in the Environmental influences on Child Health Outcomes program who contributed information on prenatal depression and autism‐related traits. Autism‐related traits were assessed continuously and at the diagnostic cut‐off using the Social Responsiveness Scale for children up to 12 years of age. Main analyses included 3994 parent–child pairs with prenatal depression diagnoses data; secondary analyses included 1730 parent–child pairs with depression severity data. After confounder adjustment, we observed an increase in autism‐related traits among children of individuals with prenatal depression compared to those without (adjusted β = 1.31 95% CI: 0.65, 1.98). Analyses stratified by child sex documented a similar significant association among boys (aβ = 1.34 95%CI: 0.36, 2.32) and girls (aβ = 1.26 95% CI: 0.37, 2.15). Prenatal depression was also associated with increased odds of moderate to severe autism‐related traits (adjusted odds ratio: 1.64, 95%CI: 1.09, 2.46), the screening threshold considered high risk of autism spectrum disorder (ASD) diagnosis. Findings highlight the importance of prenatal depression screening and preventive interventions for children of pregnant individuals with depression to support healthy development. Future research is needed to clarify whether these findings reflect overlap in genetic risk for depression and ASD‐related traits or another mechanism.