bluuebunny/crossref_metadata_2025_split huggingface dataset:
Kapitel 28. Theorien des Wandels und der Gestaltung von Strukturen: Gesellschaft-Natur-Perspektive
Authors: Haderer Margaret , Brand Ulrich , Daniel Antje , Exner Andreas , Fankhauser Julia , Görg Christoph , Novy Andreas , Schinko Thomas , Schlitz Nicolas , Strüver Anke 
Published: September 2023

ZusammenfassungDie Gesellschaft-Natur-Perspektive beschäftigt sich mit historisch entstandenen, tiefenwirksamen Treibern der Klimakrise. Ihr Fokus liegt auf klimaschädlichen Merkmalen von Natur-Mensch-Beziehungen, die für die westliche Moderne typisch und auch in Österreich wirksam sind. Dazu zählen Wachstumszwang, Kapitalakkumulation, dualistische Verständnisse von Natur und Mensch, Vorstellungen und Praktiken der Naturbeherrschung, sozial-ökologische Ungleichheit und disziplinäre Wissensproduktion.
Kapitel 2. Perspektiven zur Analyse und Gestaltung von Strukturen klimafreundlichen Lebens
Authors: Novy Andreas , Haderer Margaret , Kubeczko Klaus , Aigner Ernest , Bärnthaler Richard , Brand Ulrich , Brudermann Thomas , Daniel Antje , Exner Andreas , Fankhauser Julia , Getzner Michael , Görg Christoph , Jonas Michael , Ohndorf Markus , Ornetzeder Michael , Plank Leonhard , Schinko Thomas , Schlitz Nicolas , Strüver Anke , Tödtling Franz 
Published: September 2023

ZusammenfassungKapitel 2 systematisiert entlang von vier Perspektiven in den Sozialwissenschaften weit verbreitete Theorien zur Analyse und Gestaltung von Strukturen klimafreundlichen Lebens. Das Kapitel möchte Leser_innen des Berichts bewusst machen, mit wie grundlegend unterschiedlichen Zugängen Forscher_innen Strukturen klimafreundlichen Lebens analysieren. Dies ist wichtig, um zu verstehen, dass es nie nur eine, sondern immer mehrere Perspektiven auf Strukturen klimafreundlichen Lebens gibt. Dieses Bewusstsein hilft, die Komplexität der Sozialwissenschaften und damit die Komplexität der Aufgabe – Strukturen für ein klimafreundliches Leben zu gestalten – zu erfassen. Unterschiedliche Zugänge zu sehen, bedeutet auch, ein besseres Verständnis von konfligierenden Problemdiagnosen, Zielhorizonten und Gestaltungsoptionen zu entwickeln und – idealerweise – damit umgehen zu können.
Associations between anthropometric parameters and immune-phenotypical characteristics of circulating Tregs and serum cytokines
Authors: Schmitz Timo , Freuer D. , Meisinger C. , Linseisen J. 
Published: September 2023

Abstract
Objective
To investigate the associations between several anthropometric parameters and regulatory T cells (Tregs) and circulating cytokines in a population-based cohort.

Methods
Between 2018 and 2021, a total of 238 participants were examined up to three times within the scope of the MEGA study in Augsburg, Germany. Tregs were analyzed using flow cytometry and the serum concentrations of 52 cytokines were determined. Anthropometric parameters were measured, using also bioelectrical impedance analysis: body mass index (BMI), relative total body fat, relative visceral adipose tissue (rVAT), waist circumference (WC), waist-to-hip ratio (WHR) and body fat distribution. Associations were analyzed using linear mixed models with random intercept (Tregs) and conventional linear regression models (cytokines).

Results
WC and WHR were inversely associated with the general Treg subset. Four parameters (BMI, rVAT, WC, and WHR) were inversely associated with the conventional Treg population. Three cytokines showed a particularly strong association with several anthropometric parameters: the cutaneous T-cell attracting chemokine was inversely associated with anthropometric parameters, while hepatocyte growth factor and interleukine-18 showed positive associations.

Conclusions
Anthropometric measures are associated with Tregs and serum cytokine concentrations revealing new important interconnections between obesity and the adaptive immune system.
Comprehensive geriatric assessment predicts radiation-induced acute toxicity in prostate cancer patients
Authors: Paal Katarzyna , Stranz Bettina , Thurner Eva-Maria , Langsenlehner Uwe , Renner Wilfried , Brunner Thomas Baptist , Langsenlehner Tanja 
Published: September 2023

Abstract
Purpose
The purpose of the present prospective study was to evaluate the significance of geriatric conditions measured by a comprehensive geriatric assessment (GA) for the prediction of the risk of high-grade acute radiation-induced toxicity.

Methods
A total of 314 prostate cancer patients (age ≥ 65 years) undergoing definitive radiotherapy at a tertiary academic center were included. Prior to treatment, patients underwent a GA. High-grade toxicity was defined as acute toxicity grade ≥ 2 according to standard RTOG/EORTC criteria. To analyze the predictive value of the GA, univariable and multivariable logistic regression models were applied.

Results
A total of 40 patients (12.7%) developed acute toxicity grade ≥ 2; high grade genitourinary was found in 37 patients (11.8%) and rectal toxicity in 8 patients (2.5%), respectively. Multivariable analysis revealed a significant association of comorbidities with overall toxicity grade ≥ 2 (odds ratio [OR] 2.633, 95% confidence interval [CI] 1.260–5.502; p = 0.010) as well as with high-grade genitourinary and rectal toxicity (OR 2.169, 95%CI1.017–4.625; p = 0.045 and OR 7.220, 95%CI 1.227–42.473; p = 0.029, respectively). Furthermore, the Activities of Daily Living score (OR 0.054, 95%CI 0.004–0.651; p = 0.022), social status (OR 0.159, 95%CI 0.028–0.891; p = 0.036), and polypharmacy (OR 4.618, 95%CI 1.045–20.405; p = 0.044) were identified as independent predictors of rectal toxicity grade ≥ 2.

Conclusion
Geriatric conditions seem to be predictive of the development of high-grade radiation-induced toxicity in prostate cancer patients treated with definitive radiotherapy.
Quasi-Newton methods for topology optimization using a level-set method
Authors: Blauth Sebastian , Sturm Kevin 
Published: September 2023

AbstractThe ability to efficiently solve topology optimization problems is of great importance for many practical applications. Hence, there is a demand for efficient solution algorithms. In this paper, we propose novel quasi-Newton methods for solving PDE-constrained topology optimization problems. Our approach is based on and extends the popular solution algorithm of Amstutz and Andrä (J Comput Phys 216: 573–588, 2006). To do so, we introduce a new perspective on the commonly used evolution equation for the level-set method, which allows us to derive our quasi-Newton methods for topology optimization. We investigate the performance of the proposed methods numerically for the following examples: Inverse topology optimization problems constrained by linear and semilinear elliptic Poisson problems, compliance minimization in linear elasticity, and the optimization of fluids in Navier–Stokes flow, where we compare them to current state-of-the-art methods. Our results show that the proposed solution algorithms significantly outperform the other considered methods: They require substantially less iterations to find a optimizer while demanding only slightly more resources per iteration. This shows that our proposed methods are highly attractive solution methods in the field of topology optimization.
Trust-based management control in inter-organizational relationships
Authors: Waerness Kristian , Solstad Elsa , Bertheussen Bernt Arne 
Published: September 2023

AbstractHigh levels of trust can reduce the risk of inter-organizational relationships failing. Also, high levels of trust between business partners can be advantageous as less time and effort are spent controlling the motives and behavior of a company’s counterpart. This case study explores the management control systems between two small Norwegian salmon farming companies engaged in a joint venture. Specifically, we ask how trust influences management control in an inter-organizational relationship. We collected data by interviewing the management of the two companies constituting the joint venture and their collaborating partners throughout the value chain, resulting in two main findings. First, we find that collective values are the most critical control mechanism in managing the joint venture. As a result, other control mechanisms are toned down and become less prominent. Second, we find that a high level of trust enables management based on values. Hence, trust becomes directive for managing the joint venture. Our findings could be important for companies seeking to engage in different inter-organizational relationships. They indicate that it might benefit managers to seek out potential partners with the same fundamental values as themselves to facilitate trust-building.
Prognostic impact of MYD88 and TP53 mutations in diffuse large B Cell lymphoma
Authors: Ebid Osama Abd El Hameed , Ezz El Arab Lobna R. , Saad Amr S. , Ezz El Din Mai , Mostafa Nermeen , Swellam Menha 
Published: September 2023

AbstractDiffuse large B cell lymphoma (DLBCL) is the most common subtype of lymphoma. It is a highly heterogeneous lymphoid neoplasm, with variations in gene expression profiles and genetic alterations. MYD88 and TP53 genes are common to be expressed and mutated in DLBCL patients with controversy regarding their role in prognosis and survival. This study aims to determine the predictive and prognostic role of MYD88 and TP53 gene mutation in DLBCL. A prospective cohort study was conducted on 50 patients who were diagnosed with DLBCL and 30 healthy individuals to assess the sensitivity and specificity of MYD88 and TP53 genetic mutations. MYD88 and TP53 gene mutations were more sensitive, specific, and accurate in predicting overall mortality and disease progression in comparison with the international prognostic index. Mutant MYD88 and TP53 showed their prognostic importance for worse objective response rates and survival outcomes. Both mutant MYD88 and TP53 were associated with worse ORR. There was a significant statistical difference for both MYD88 and TP53 with regard to 2-year PFS and 2-year OS rate. Hence, both mutant MYD88 and TP53 can be used in predicting disease progression and overall mortality.
The expected loss of feature diversity (versus phylogenetic diversity) following rapid extinction at the present
Authors: Overwater Marcus , Pelletier Daniel , Steel Mike 
Published: September 2023

AbstractThe current rapid extinction of species leads not only to their loss but also the disappearance of the unique features they harbour, which have evolved along the branches of the underlying evolutionary tree. One proxy for estimating the feature diversity (FD) of a setSof species at the tips of a tree is ‘phylogenetic diversity’ (PD): the sum of the branch lengths of the subtree connecting the species inS. For a phylogenetic tree that evolves under a standard birth–death process, and which is then subject to a sudden extinction event at the present (the simple ‘field of bullets’ model with a survival probability ofsper species) the proportion of the originalPDthat is retained after extinction at the present is known to converge quickly to a particular concave function$$\varphi _{PD}(s)$$φPD(s)astgrows. To investigate how the loss ofFDmirrors the loss ofPDfor a birth–death tree, we modelFDby assuming that distinct discrete features arise randomly and independently along the branches of the tree at raterand are lost at a constant rate$$\nu $$ν. We derive an exact mathematical expression for the ratio$$\varphi _{FD}(s)$$φFD(s)of the two expected feature diversities (prior to and following an extinction event at the present) astbecomes large. We find that although$$\varphi _{FD}$$φFDhas a similar behaviour to$$\varphi _{PD}$$φPD(and coincides with it for$$\nu =0$$ν=0), when$$\nu >0$$ν>0,$$\varphi _{FD}(s)$$φFD(s)is described by a function that is different from$$\varphi _{PD}(s)$$φPD(s). We also derive an exact expression for the expected number of features that are present in preciselyoneextant species. Our paper begins by establishing some generic properties of FD in a more general (non-phylogenetic) setting and applies this to fixed trees, before considering the setting of random (birth–death) trees.
Coronary CT angiography for the assessment of atherosclerotic plaque inflammation: postmortem proof of concept with histological validation
Authors: Rotzinger David C. , Magnin Virginie , van der Wal Allard C. , Grabherr Silke , Qanadli Salah D. , Michaud Katarzyna 
Published: September 2023

Abstract
Objectives
To evaluate the diagnostic utility of multiphase postmortem CT angiography (PMCTA) to detect plaque enhancement as a surrogate marker of inflammation, using fatal coronary plaques obtained from autopsies following sudden cardiac death.

Methods
In this retrospective study, we included 35 cases (12 women, 34%; median [IQR] age, 52 [11] years), with autopsy-proven coronary thrombosis, histological examination, and multiphase PMCTA. Two radiologists blinded towards histological findings assessed PMCTA for plaque enhancement of the culprit lesion in consensus. Two forensic pathologists determined the culprit lesion and assessed histological samples in consensus. Cases with concomitant vasa vasorum density increase and intraplaque and periadventital inflammation were considered positive for plaque inflammation. Finally, we correlated radiology and pathology findings.

Results
All 35 cases had histological evidence of atherosclerotic plaque disruption and thrombosis; 30 (85.7%) had plaque inflammation. Plaque enhancement at multiphase PMCTA was reported in 21 (60%) and resulted in a PPV of 95.2% (77.3–99.2%) and an NPV of 28.6% (17–43.9%). Median histological ratings indicated higher intraplaque inflammation (p = .024) and vasa vasorum density (p = .032) in plaques with enhancement. We found no evidence of a difference in adventitial inflammation between CT-negative and CT-positive plaques (p = .211).

Conclusions
Plaque enhancement was found in 2/3 of fatal atherothrombotic occlusions at coronary postmortem CT angiography. Furthermore, plaque enhancement correlated with histopathological plaque inflammation and increased vasa vasorum density. Plaque enhancement on multiphase CT angiography could potentially serve as a noninvasive marker of inflammation in high-risk populations.

Clinical relevance statement
Phenotyping coronary plaque more comprehensively is one of the principal challenges cardiac imaging is facing. Translating our ex vivo findings of CT-based plaque inflammation assessment into clinical studies might help pave the way in defining high-risk plaque better.

Key Points
• Most thrombosed coronary plaques leading to fatality in our series had histological signs of inflammation.
• Multiphase postmortem CT angiography can provide a noninvasive interrogation of plaque inflammation through contrast enhancement.
• Atherosclerotic plaque enhancement at multiphase postmortem CT angiography correlated with histopathological signs of plaque inflammation and could potentially serve as an imaging biological marker of plaque vulnerability.
Effect of late gadolinium enhancement on left atrial impairment in myocarditis patients
Authors: Cau Riccardo , Muscogiuri Giuseppe , Pisu Francesco , Mannelli Lorenzo , Sironi Sandro , Suri Jasjit S. , Pontone Gianluca , Saba Luca 
Published: September 2023

Abstract
Objective
The aims of our study were to investigate the effect of the extent and location of late gadolinium enhancement (LGE) on the left atrium (LA) function in patients with acute myocarditis (AM) using cardiovascular magnetic resonance (CMR).

Method
This retrospective study performed CMR scans in 113 consecutive patients (89 males, 24 females; mean age 45.8 ± 17.3 years) with AM that met the updated Lake Louise criteria. Reservoir, conduit, and booster LA functions were analyzed by CMR feature tracking using dedicated software. Besides LA strain measurements, myocardial scar location and extent were assigned and quantified by LGE imaging.

Results
AM patients with septal LGE had impaired reservoir, conduit, and conduit strain rate function in comparison with AM patients with non-septal LGE (p = 0.001, for all). In fully adjusted multivariable linear regression, reservoir and conduit were significantly associated with left ventricle (LV) LGE location (β coefficient = 8.205, p = 0.007; β coefficient = 5.185, p = 0.026; respectively). In addition, LA parameters decreased according to the increase in the extent of LV fibrosis (LGE ≤ 10%; LGE 11–19%; LGE ≥ 20%). After adjustment in multivariable linear regression, the association with LV LGE extent was no longer statistically significant.

Conclusion
In patients with acute myocarditis, LA function abnormalities are significantly associated with LV LGE location, but not with LGE extent. Septal LGE is paralleled by a deterioration of LA reservoir and conduit function.

Clinical relevance statement
Left atrium dysfunction is associated with the presence of late gadolinium enhancement in the left ventricle septum and can be useful in the clinical prognostication of patients with acute myocarditis, allowing individually tailored treatment.

Key Points
• Myocardial fibrosis is related to atrial impairment.
• The location of myocardial fibrosis is the main determinant of atrial dysfunction in myocarditis patients.
• The quantification of atrial mechanisms may provide more in-depth insight into myocarditis pathophysiology.
Continuous irrigation after pancreatectomy: a systematic review
Authors: Pergolini Ilaria , Scheufele Florian , Demir Elke , Schorn Stephan , Friess Helmut , Ceyhan Güralp O. , Demir Ihsan Ekin 
Published: September 2023

Abstract
Purpose
Prevention and management of postoperative pancreatic fistula (POPF) after pancreatic resections is still an unresolved issue. Continuous irrigation of the peripancreatic area is frequently used to treat necrotizing pancreatitis, but its use after elective pancreatic surgery is not well-known. With this systematic review, we sought to evaluate the current knowledge and expertise regarding the use of continuous irrigation in the surgical area to prevent or treat POPF after elective pancreatic resections.

Methods
A systematic search of the literature was conducted according to the PRISMA 2020 guidelines, screening the databases of Pubmed, Scopus, Web of Science, and Ovid MEDLINE. Because of the heterogeneity of the included articles, a statistical inference could not be performed and the literature was reviewed only descriptively. The study was pre-registered online (OSF Registry).

Results
Nine studies were included. Three studies provided data regarding the prophylactic use of continuous irrigation after distal and limited pancreatectomies. Here, patients after irrigation showed a lower rate of clinically relevant POPF, related complications, lengths of stay, and mortality. Six other papers reported the use of local lavage to treat clinically relevant POPF and subsequent fluid collections, with successful outcomes.

Conclusion
In the current literature, only a few publications are focused on the use of continuous irrigation after pancreatic resection to prevent or manage POPF. The included studies showed promising results, and this technique may be useful in patients at high risk of POPF. Further investigations and randomized trials are needed.
Neurovascular coupling during auditory stimulation: event-related potentials and fNIRS hemodynamic
Authors: Muñoz Vanesa , Muñoz-Caracuel Manuel , Angulo-Ruiz Brenda Y. , Gómez Carlos M. 
Published: September 2023

AbstractIntensity-dependent amplitude changes (IDAP) have been extensively studied using event-related potentials (ERPs) and have been linked to several psychiatric disorders. This study aims to explore the application of functional near-infrared spectroscopy (fNIRS) in IDAP paradigms, which related to ERPs could indicate the existence of neurovascular coupling. Thirty-three and thirty-one subjects participated in two experiments, respectively. The first experiment consisted of the presentation of three-tone intensities (77.9 dB, 84.5 dB, and 89.5 dB) lasting 500 ms, each type randomly presented 54 times, while the second experiment consisted of the presentation of five-tone intensities (70.9 dB, 77.9 dB, 84.5 dB, 89.5 dB, and 94.5 dB) in trains of 8 tones lasting 70 ms each tone, the trains were presented 20 times. EEG was used to measure ERP components: N1, P2, and N1–P2 peak-to-peak amplitude. fNIRS allowed the analysis of the hemodynamic activity in the auditory, visual, and prefrontal cortices. The results showed an increase in N1, P2, and N1–P2 peak-to-peak amplitude with auditory intensity. Similarly, oxyhemoglobin and deoxyhemoglobin concentrations showed amplitude increases and decreases, respectively, with auditory intensity in the auditory and prefrontal cortices. Spearman correlation analysis showed a relationship between the left auditory cortex with N1 amplitude, and the right dorsolateral cortex with P2 amplitude, specifically for deoxyhemoglobin concentrations. These findings suggest that there is a brain response to auditory intensity changes that can be obtained by EEG and fNIRS, supporting the neurovascular coupling process. Overall, this study enhances our understanding of fNIRS application in auditory paradigms and highlights its potential as a complementary technique to ERPs.
A qualitative stakeholder analysis of beliefs, facilitators, and barriers for a feasible prehabilitation program before lung cancer surgery
Authors: Voorn M. J. J. , Bastiaansen E. M. W. , Schröder C. D. , van Kampen-van den Boogaart V. E. M. , Bootsma G. P. , Bongers B. C. , Janssen-Heijnen M. L. G. 
Published: September 2023

Abstract
Background
In order to develop a feasible prehabilitation program before surgery of NSCLC, this study aimed to gain insight into beliefs, facilitators, and barriers of (1) healthcare professionals to refer patients to a prehabilitation program, (2) patients to participate in and adhere to a prehabilitation program, and (3) informal caregivers to support their loved ones.

Methods
Semi-structured interviews were conducted with healthcare professionals, patients who underwent surgery for NSCLC, and their informal caregivers. The capability, opportunity, and motivation for behavior-model (COM-B) guided the development of the interview questions. Results were analyzed thematically.

Results
The interviews were conducted with twelve healthcare professionals, seventeen patients, and sixteen informal caregivers. Four main themes were identified: (1) content of prehabilitation and referral, (2) organizational factors, (3) personal factors for participation, and (4) environmental factors. Healthcare professionals mentioned that multiple professionals should facilitate the referral of patients to prehabilitation within primary and secondary healthcare involved in prehabilitation, considering the short preoperative period. Patients did not know that a better preoperative physical fitness and nutritional status would make a difference in the risk of postoperative complications. Patients indicated that they want to receive information about the aim and possibilities of prehabilitation. Most patients preferred a group-based physical exercise training program organized in their living context in primary care. Informal caregivers could support their loved one when prehabilitation takes place by doing exercises together.

Conclusion
A prehabilitation program should be started as soon as possible after the diagnosis of lung cancer. Receiving information about the purpose and effects of prehabilitation in a consult with a physician seems crucial to patients and informal caregivers to be involved in prehabilitation. Support of loved ones in the patient’s own living context is essential for adherence to a prehabilitation program.