bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Effects of a Telenursing Scheduled Intervention of Brief Behavioral Activation Therapy on Depression and Anxiety Symptoms of Patients with Mixed Depression and Anxiety Disorder
Authors: Hayati Mahsa Sadat , Shams Jamal , Ghadirian Fataneh , Meybodi Sara Sadeghipour , Shafighi Amir Hossein 
Published: March 2023

Abstract
Background

Although many studies have been conducted on the efficacy of behavioral activation in depression, there are few sources that have evaluated the efficacy of this treatment in depressed patients with anxiety through telecare. The study is designed aiming to determining the Effects of a telenursing scheduled intervention of brief behavioral activation therapy on depression and anxiety symptoms of patients with mixed anxiety and depression Disorder (MADD).

Methods

The study was a randomized clinical trial in which 30 subjects with MADD were randomly assigned to an intervention and a control group based on inclusion criteria. The 8-session person-centered behavioral activation was delivered twice weekly via tele-nursing. Depression and anxiety symptoms severity were assessed using the Hamilton Anxiety Rating Scale and the Hamilton Depression Rating Scale at baseline, end, and 1 month after the intervention. Data were analyzed by independent t-tests, chi-square tests, and repeated-measures tests using SPSS version 24.

Results

The results showed that after the implementation of the intervention, the depression score in the intervention group had decreased from 19.86 (± 8.56) to 17.21 (± 6.71). In contrast, it increased from 18.67 (± 9.72) to 19.47 (± 7.33) in the control group. For anxiety symptoms, there was a clinically significant decrease after the intervention only in the intervention group (p = 0.01).

Conclusion

The results showed the effects of brief behavioral activating tele-nursing on a non-significant reduction in depression symptoms and a significant clinical reduction in anxiety symptoms after the intervention in MADD patients. It seems that brief BA tele-therapy could be a good alternative for discharged patients and a good complementary method for long-term treatment in primary care nursing.
Trial registration: IRCT20151003024312N6
Date of first registration: 13/09/2021
Multi-center, randomized controlled, open evaluation of efficacy and safety of Arbidol hydrochloride tablets in the treatment of influenza-like cases
Authors: Bai Xinfeng , Xi Suya , Chen Guiyan , Fan Xiaoying , Wang Kaiwei , Li Yong , Zhao Yang , Wang Weizhan , Tian Yingping 
Published: March 2023

Abstract
Objective To study the efficacy and safety of Arbidol hydrochloride tablets in the treatment of influenza-like cases. Methods A multicenter, randomized controlled, open study was conducted. 412 influenza-like cases were collected from 14 hospitals in 7 regions of Hebei Province from September 2021 to March 2022. They were randomly divided into 2 groups. 207 patients in the control group were given oseltamivir phosphate capsules for 5 days. 205 patients in the experimental group were given Arbidol hydrochloride tablets for 5 days. The primary endpoint was the time to normal body temperature, and the secondary endpoint included the time to remission of influenza symptoms, the incidence of influenza-like complications, and the incidence of adverse reactions.
Results 1) Before treatment, there was no significant difference between the two groups in general conditions, blood routine, body temperature and symptom severity.2) After treatment, there was no significant difference between the experimental group and the control group in the mean remission time of fever (59.24 ± 25.21) H vs. (61.05 ± 29.47) H and the mean remission time of influenza symptoms (57.31 ± 30.19) H vs. (62.02 ± 32.08) H. Survival analysis Logrank and Wilcoxon bilateral test showed that there was no significant difference in fever relief time and influenza symptom relief time between the two groups.3) Incidence of complications and adverse events: there was only 1 case of tracheitis in the control group. In the control group, nausea occurred in 1 case, vomiting in 1 case and dizziness in 1 case. In experimental group, nausea occurred in 1 case, vomiting in 1 case and drowsiness in 1 case. In addition, 1 patient in control group was hospitalized for urinary calculi.
Conclusion There is no significant difference between Arbidol hydrochloride tablets and Oseltamivir phosphate capsules in the treatment of influenza like cases, and Arbidol hydrochloride tablets have less adverse reactions and are safe to use.
The key role of non-local screening in the environment-insensitive exciton fine structures of transition-metal dichalcogenide monolayers
Authors: Cheng Shun-Jen , Li Wei-Hua , Lin Jhen-Dong , Lo Ping-Yuan , Peng Guan-Hao , Hei Ching-Yu , Chen Shao-Yu 
Published: March 2023

Abstract
In this work, we present a comprehensive theoretical and computational investigation of exciton fine structures of WSe2-monolayers, one of the best known two-dimensional (2D) transition-metal dichalcogenides (TMD's), in various dielectric-layer environments by solving the first-principles-based Bethe-Salpeter equation. While the physical and electronic properties of atomically thin nano-materials are normally sensitive to the variation of surrounding environment, our studies reveal that the influence of dielectric environment on the exciton fine structures of TMD-ML’s is surprisingly limited. We point out that the non-locality of Coulomb screening plays a key role to suppress the factor of dielectric environment and drastically shrink the fine structure splittings between bright exciton (BX) states and various dark exciton (DX) states of TMD-ML's.The intriguing non-locality of screening in 2D materials can be manifested by the measurable non-linear correlation between the BX-DX splittings and exciton binding energies with varying the surrounding dielectric environments. The revealed environment-insensitive exciton fine structures of TMD-ML's suggest the robustness of prospective dark-exciton-based opto-electronics against the inevitable variation of inhomogeneous dielectric environment.
Leveraging electronic health records to identify risk factors for recurrent pregnancy loss across two medical centers: a case-control study
Authors: Roger Jacquelyn , Xie Feng , Costello Jean , Tang Alice , Liu Jay , Oskotsky Tomiko , Woldemariam Sarah , Kosti Idit , Le Brian , Snyder Michael , Giudice Linda , Torgerson Dara , Shaw Gary , Stevenson David , Rajkovic Aleksandar , Aghaeepour Nima , Glymour M. , Cakmak Hakan , Lathi Ruth , Sirota Marina 
Published: March 2023

Abstract

Recurrent pregnancy loss (RPL), defined as 2 or more pregnancy losses, affects 5-6% of
ever-pregnant individuals. Approximately half of these cases have no identifiable explanation.
To generate hypotheses about RPL etiologies, we implemented a case-control study comparing
the history of over 1,600 diagnoses between RPL and live-birth patients, leveraging the
University of California San Francisco (UCSF) and Stanford University electronic health record
databases. In total, our study included 8,496 RPL (UCSF: 3,840, Stanford: 4,656) and 53,278
Control (UCSF: 17,259, Stanford: 36,019) patients. Menstrual abnormalities and
infertility-associated diagnoses were significantly positively associated with RPL in both medical
centers. Age-stratified analysis revealed that the majority of RPL-associated diagnoses had
higher odds ratios for patients <35 compared with 35+ patients. While Stanford results were
sensitive to control for healthcare utilization, UCSF results were stable across analyses with and
without utilization. Intersecting significant results between medical centers was an effective filter
to identify associations that are robust across center-specific utilization patterns.
Comparative analysis of dislocation rates for total hip replacement arthroplasty using fixed bearing acetabular cup and dual mobility acetabular cup in patients with hip dysplasia
Authors: Kim Jung Shin , Moon Nam Hoon , Do Min Uk , Jung Sung Won , Suh Kuen Tak , Shin Won Chul 
Published: March 2023

Abstract
Background
Total hip replacement arthroplasty (THA) in hip dysplasia patients has a higher complication rate than in patients with simple hip osteoarthritis due to anatomical deformation and previous surgical history. Hence the associated complications need to be probed.
Methods
From 2015 to 2020, 1525 patients underwent THA performed by two surgeons at a single institution. A total of 152 patients involving 172 THAs were included. Hip dysplasia was evaluated radiologically using Crowe classification. The patients were classified into dual-mobility (DM) and fixed-bearing (FB) acetabular cup groups. The occurrence of postoperative complications, including dislocation and functional evaluation of the hip joint, was analyzed before and after surgery using the modified Harris hip score.
Results
There was no difference in the preoperative demographics and radiographic parameters between the groups. The size of the external bearing of the DM acetabular cup (41.83 ± 2.66 mm) and the size of the femoral head implant in the FB acetabular cup (33.03 ± 1.99 mm) were significantly different (P value < 0.001). The incidence of postoperative hip dislocation was significantly lower in the DM group (DM 0% vs. FB 9.0%) (P value = 0.003). The hip joint function score showed no difference before surgery (DM 42.92 vs FB 50.12) or 2 years after surgery (DM 91.80 vs FB 92.03).
Conclusion
Treating hip dysplasia patients with THA using a dual-mobility acetabular cup can reduce postoperative dislocations, and could be used for the better management of these patients.
Effect of doxorubicin on viability and Bax, Bcl-2, p53, Nanog, Sox-2, Oct-4 gene expressions in MCF-7 stem-like cells
Authors: Andac Cenk A , Kocak Nadir , Dalan Altay Burak , Caglar Sena , Arslan Seyfullah O 
Published: March 2023

Abstract
Background: The aim of this study is to clarify whether cell viability, cell death, and gene expressions pertaining to self-renewal and pluripotency differ in doxorubicin (DOX) [IC50] treated and untreated human MCF-7 mammalian cancer cells as well as between their CD44+/CD24¯/low cancer stem cells (CSC).
Methods: Non-tumorigenic human MCF-10A mammalian cells and their CD44+/CD24¯/low stem cells were used as the control. Cell viability, apoptosis, necrosis and cell death were studied by flow cytometry. Cell death pathways, multidrug resistance, pluripotency and self-renewal were studied at Nanog, Oct-4, Sox-2, p53, Bcl-2 and Bax mRNA gene expression level by qRT-PCR.
Results: IC50 value for DOX treated MCF-7 cells was found to be 3.73 µM. Bax, Bcl-2, p53 genes were down-regulated while Nanog, Oct-4, Sox-2 genes were up-regulated in DOX [IC50] treated MCF-7 CSCs. Bax, p53, Nanog, Oct-4 genes were down-regulated while Sox-2, Bcl-2 genes were up-regulated in DOX [IC50] untreated MCF-7 CSCs.
Discussion: In addition to literature reports on DOX [IC50] treated non-stem MCF-7 cells undergoing autophagy and DOX [IC50] treated dedifferentiated MCF-7 (CD44+/CD24¯/low) cancer stem-like cells undergoing apoptosis, our laboratory data strongly suggest that DOX [IC50] treated MCF-7 CSCs also undergo necrosis as determined by flow cytometry and necroptosis due to downregulation of Bax, Bcl-2 and p53 genes.
Conclusion: Our finding suggests that multiple types of cell death pathways, including apoptosis, necrosis and necroptosis, is involved in DOX [IC50] treated MCF-7 CSCs. DOX [IC50] treated MCF-7 CSCs become pluripotent with self-renewal capability by up-regulation of Nanog, Oct-4, Sox-2 gene expressions to possibly survive necroptosis. Nanog, Oct-4, Sox-2 gene expressions are all down-regulated in DOX [IC50] treated MCF-10A (CD44+/CD24¯/low) stem cells, disabling the self-renewal and pluripotency features.
Full length transcriptome sequencing and differential expression gene analysis of Hybrid Larch under PEG simulated drought stress
Authors: Zhao Qingrong , Wang Chen , Zhang Sufang , Zhang Hanguo , Zhang Lei 
Published: March 2023

Abstract
Hybrid larch is one of the main afforestation and timber species in northeast China. Drought is one of the main factors limiting the growth of larch and other organisms. To further explore the mechanism of drought resistance of hybrid larch , the full-length sequencing of hybrid larch embryogenic callus under PEG simulated drought stress was carried out by combining Illumina-Hiseq and SMRT-seq. A total of 20.3Gb clean reads and 786492 CCS reads were obtained from the second and third generation sequencing. The de-redundant transcript sequences were predicted by lncRNA, 2083 lncRNAs were obtained, and the target genes were predicted, and a total of 2722 target genes were obtained. The de-redundant transcripts were further screened and 1654 differentially expressed genes (DEGs )were obtained. Among them, different DEGs respond to drought stress through different ways, such as Oxidation-reduction process, Starch and sucrose metabolism, Plant hormone pathway, Carbon metabolism, lignin catabolic/biosynthetic process and so on. This study provides basic full-length sequencing data for the study of Larch drought resistance, and excavates a large number of DEGs in response to drought stress, which helps us to further understand the function of Larch drought resistance genes and provides a reference for in-depth analysis of the molecular mechanism of Larch drought resistance.
Classification of the oesophageal perforation
Authors: Harrich Friederike H. M. , Knoefel Wolfram Trudo , Bölke Edwin , Schauer Matthias C. 
Published: March 2023

Abstract

Objectives
Oesophageal perforations are a complex clinical scenario that has been poorly studied.
To date, there is no staging of oesophageal perforation. The outcome is often fatal and heterogeneous, which is related to the fact that there is no classification and no treatment guideline.
Methods
The observation period of the study covered a period of four years. The cause of the injury and the time interval between the event and the start of therapy were analyzed. Therapy and the clinical signs of infection were evaluated.
Endpoints of the study were patient recovery or death due to sepsis.
The study was conducted as a retrospective single-center study in a maximum-care hospital and has been approved by the review board. Patients gave informed consent before data collection. All data were analyzed using SPSS (IBM SPSS Statistics software).
Results
For this study, oesophageal perforation cases from a maximum care hospital were summarized and classified for the first time, from which a prediction of lethality could be derived. The proposed endoscopic radiological classification correlated with survival in our study. Accordingly, we were able to suggest a therapeutic option to the different stages. It can be seen that lethality correlates significantly with the severity of the perforation. As a final result of the study a prediction of mortality at diagnosis is now possible.
Conclusion
Oesophageal perforations can be systematically classified into grades I to IV, with grade III divided into a, b, and c according to the height of the perforation in relation to the anatomy. A treatment guideline can now be discussed according to the severity of the perforation.
Cattle Manure Application for 12-17 Years Enhanced Depth Distribution of X-Ray Computed Tomography-Derived Soil Pore Characteristics
Authors: Sangotayo Anuoluwa Ojonoka , Chakraborty Poulamee , Xu Sutie , Kumar Sandeep , Kovacs Peter 
Published: March 2023

Abstract
Long-term manure and inorganic fertilizer application in row crops may significantly influence soil pore characteristics, thereby impacting soil aggregation and structure. Understanding the influence of such soil amendments on soil pore characteristics is useful to develop proper conservation practices. However, there is limited information on the impact of cattle manure and inorganic fertilizer application on soil pore characteristics at a microscale level in the soil profile. Therefore, in this study, the X-ray computed tomography (XCT) technique was utilized to quantify the impact of manure and fertilizer amendments under a corn (Zea mays L.)-soybean (Glycine max L.)-spring wheat (Triticum aestivum) rotation system on soil pore characteristics to 40 cm soil depth. The study was conducted at Brookings (initiated in 2008) and Beresford (2003) in South Dakota. The study treatments included: low manure (LM), medium manure (MM), high manure (HM), medium fertilizer (MF), high fertilizer (HF), and control (CK). Four replicated intact cores were collected from all the treatments at 0–10, 10–20, 20–30, and 30–40 cm depths. Image visualization and processing were performed using ImageJ software at a pixel resolution of (0.26 × 0.26 × 0.28) mm3. Data showed that treatments by depth interactions were mainly significant for soil organic carbon (SOC) content at 0–20 cm. The HM treatment increased the SOC by 8 to 68% compared to the CK and MF at 0–20 cm for either site. However, treatments did not always impact these parameters beyond 20 cm depth. Considering treatment as the main effect, the MM, HM, and HF increased the total number of pores (TP) compared to the CK at Beresford site. Soil depth impacted the TP and total number of macropores (Tmacro), where more Tmacro was observed at 0–10 cm compared to the 30–40 cm depth at Beresford site. In general, manure application improved SOC and TN contents and soil pore characteristics at 0–20 cm for both sites. This study illustrates the importance of the XCT technique in quantifying soil pore characteristics and highlighted the improvement in the XCT-derived pore characteristic with the long-term application of manure to a greater depth in the soil.
Public Perspectives on Strays and Companion Animal Management in Malaysia
Authors: Munir Syafiq Munir Ismail , Mokhtar Mohd Istajib , Arham Ahmad Firdhaus 
Published: March 2023

Abstract
Strays and companion animal management is a sensitive issue in Malaysia that incites solid and conflicting views. Through structured questionnaires administered to a random sample of 704 respondents, this study explored public opinion on a) causes of the stray animal population, b) the management of the stray animal population, and c) the national strategy on strays and companion Animal Management. The results show that 70.3% of respondents agreed that a lack of public awareness regarding animal care was the major contributor to the stray animal population. In addition, 58.1% of respondents felt that treating and vaccinating animals exposed to zoonotic diseases is a viable approach that could be instituted as a conceivable measure in stray animal population management. Finally, developing animal protection areas through a multi-stakeholder partnership strategy initiative recorded the highest support (48.4%) for intervention planning for stray animal management at a national level. Notably, a significant percentage of public responses were implicitly influenced by demographic variables. These findings provide valuable insights into public opinion regarding stray and companion animal management in Malaysia. These findings could inform the development of future legislation aimed at reducing the unfavorable effects of stray animal populations on humans and the ecology of Malaysia.
Altered dynamic functional and effective connectivity in drug-naive children with Tourette Syndrome
Authors: Qu Haibo , Luo Lekai , Liao Yi , Jia Fenglin , Ning Gang , Liu Jing , Li Xuesheng , Chen Xijian , Ma Xinmao , He Xuejia , Fu Chuan , Cai Xiaotang 
Published: March 2023

Abstract
Tourette syndrome (TS) is a developmental neuropsychiatric disorder characterized by repetitive, stereotyped, involuntary motor and vocal tics, the neurological basis of which remains unclear. Although traditional resting-state MRI (rfMRI) studies have identified abnormal static functional connectivity (FC) in patients with TS, dynamic FC (dFC) remains relatively unexplored. The rfMRI data of 54 children with TS and 46 typically developing children (TDC) were analyzed using group independent component analysis to obtain independent components (ICs), and a sliding-window approach to generate dFC matrices. All dFC matrices were clustered into two reoccurring states, the state transition metrics were obtained. We conducted Granger causality and degree centrality analyses to further investigate the brain regions that may play the most important roles in driving whole-brain switching between different states. We found that children with TS spent more time in state 2 (PFDR < 0.001), a state characterized by strong connectivity between ICs, and switched more quickly between states (PFDR = 0.025) than TDC. The default mode network (DMN) may play an important role in abnormal state transitions because the FC that changed the most between the two states was between the DMN and other networks. Additionally, the DMN had increased centrality and altered causal influence on other networks. Certain alterations related to cognitive function (r = – 0.309, P < 0.05) and tic symptom ratings (r = 0.282; 0.413, P < 0.05) may represent important aspects of the pathophysiology of TS. These findings facilitate our understanding of the neural basis for the clinical presentation of TS.
Dissociation of perception and motor execution of lower limb in multi-directional movements
Authors: Oku Kyosuke , Tanaka Shinsuke , Kida Noriyuki 
Published: March 2023

Abstract
Estimating action capability is important for humans to successfully move their bodies. Reachability has been proposed to be an overestimation of motor abilities, by judging the unreachable distance as reachable. Existing literature have mainly investigated the sagittal direction, but multi-directional reachability is unexplored. This study examined the relationship between cognition and movement using the reaching of the lower limbs in multiple directions. Sixteen adults were asked to reach targets projected on the floor in 21 locations (seven directions and three distances) to estimate the reaching time. We found that movement slowed as the direction increased toward the contralateral side, but subjective reaching time did not change with direction. Multiple regression analysis showed that subjective reaching time could be calculated with high accuracy, using mainly the duration from the toe leaving the ground to movement completion. These results suggest that changes in direction may not be perceived precisely by the motor system of the lower limbs, and subjective reaching time was strongly affected by the time after the toe- left the ground. Our findings provide novel insights into the relationship between motor and cognition in multiple directions, which may provide a new strategy for the maximal performance of lower limb movement.