bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bioètica y Derecho
Authors: Jurado Parres Hans , González Sánchez Amalia Karolina 
Published: June 2023

El tema de la bioética, actualmente, se encuentra en su pleno auge y, es por ello que, ésta comienza a intervenir en las diversas ciencias de la vida y ciencias sociales, entre ellas el derecho. Esta intervención podría ser considerada como invasora del derecho, si es que no se observan determinados límites.
El objeto de éste artículo es plasmar una perspectiva objetiva de la relación y operación existente entre la bioética y el derecho y, para ello, a través de una investigación bibliográfica se plasmó la conceptualización de “derecho”, “bioética”; asimismo, se plasmó inminente relación que existe entre éstos, como lo es: la conexión práctica, legislativa e interpretativa. Por último, se plasmaron los límites que la bioética debe de observar al intervenir en la competencia del derecho, esto, con la finalidad de no empoderar a la primera frente a la segunda.
Desigualdad y discriminación en el diseño de las políticas públicas en materia indigenista.
Authors: Orozco Quezada Claudia Selene 
Published: June 2023

La idea principal de este documento es exponer la manera en que ha incidido el diseño de políticas públicas en materia indígena en el rezago social en el que se encuentran los pueblos originarios desde hace décadas. Es de vital importancia comprender las razones por las que el desarrollo de las comunidades indígenas no ha despegado y el rechazo que expresan a la idea de la asimilación, así como conocer las áreas de oportunidad en las que el Estado debe prestar atención para reducir la brecha de desigualdad en la que se encuentran los indígenas en nuestro país.
Se presentan datos estadísticos, que nos permiten conocer el un diagnóstico de las condiciones de pobreza y desigualdad de oportunidades de este segmento de la población. Se revisa el principio de igualdad y no discriminación, así como los retos a los que se enfrenta la autoridad en el diseño de políticas públicas.
Cómo realizar un Proyecto de Investigación en un Posgrado en Derecho
Authors: Preciado Rodriguez Teresa Magnolia , González Cortez Adrian 
Published: June 2023

El presente trabajo tiene como objetivo presentar los elementos para elaborar un proyecto de investigación en un posgrado en Derecho, en el cual se muestra como guía práctica de cada una de las etapas para culminar el proyecto y con ello obtener de manera satisfactoria la aprobación del mismo por parte de la Institución en la que se encuentre cursando, a efecto de poder obtener el dictamen final que lo avale como Protocolo de Investigación, aprobado por la máxima autoridad académica del Posgrado.
Derecho humano a la salud: Innovadoras Modalidades Terapéuticas Científicamente Probadas
Authors: Roque  Huerta Edith , Marín Castañeda María 
Published: June 2023

La protección de la salud es un derecho universal plenamente reconocido y protegido, en México, en la Carta Magna establece en su artículo 4° que “Toda persona tiene derecho a la protección de la salud. La ley definirá las bases y modalidades para el acceso a los servicios de salud y establecerá la concurrencia de la Federación y las entidades federativas en materia de salubridad general”.
La Organización Mundial de la Salud (OMS) desde 1956 declaro a las adicciones como enfermedad relacionada a un trastorno por consumo de sustancias que afecta al cerebro y el comportamiento de una persona y produce incapacidad de controlar el consumo de medicamentos o drogas legales o ilegales, en consecuencia, las adicciones son consideradas un problema de salud pública en nuestro país, el cual enfrenta un gran reto para solucionarlo.
Analisa Literasi Keuangan pada Usaha Mikro Kecil Dan Menengah (UMKM) Batik di Kota Jambi
Authors: Utama Ahmad Nur Budi , Suryani Ade Irma 
Published: June 2023

The purpose of this study is to find out how experienced Batik micro, small and medium enterprises (MSMEs) in Jambi City are in financial matters. Data collection techniques through conversations or interviews with informants representing small and medium enterprises, and interviews conducted face-to-face. The aspects of financial literacy studied are: 1) Aspects of financial knowledge; (2) Aspects of financial behavior; 3) Aspects of financial attitudes; and 4) Aspects of financial capability. The results showed that (1) The aspect of financial knowledge shows that Batik MSME actors in Jambi City are able to use supporting devices, and financial products and make financial reports to support their business; (2) The aspect of financial behavior shows that Batik MSME actors in Jambi City are aware of paying taxes, setting aside money for savings, and recording finances accurately; (3) The aspect of financial attitude shows that Batik MSME actors in Jambi City are able to manage expenses rationally; and (4) The financial capability aspect shows that Batik MSME players in Jambi City are able to have strategies and plans for where and how money will be spent and track savings balances.
Bibliographic practice as an object of bibliographic studies
Authors: Likhovid T. F. 
Published: June 2023

Review of the joint monograph “Essays on bibliographic activity of the Russian State Library: A monograph” / Russian State Library ; ed. by G. L. Levin. Moscow : Pashkov dom, 2022. 734 p.The author reviews the joint monograph by the leading specialists of the Russian State Library (RSL). The article is publishedon the occasion of the 100th anniversary of the reference and information office as the division of the library of State Rumyantsev Museum in December 1918. The office rendered all types of bibliographic user services (e. g. address, subject, specifying bibliographic references). The reviewed monograph covers all the main fields of RSL’s bibliographic activity: development of reference library collection, reference and information services, building of all the main types of bibliographic directories, bibliographical information service in culture and arts, making of bibliographical indices of Russian emigration literature, research in theory of bibliography, etc. The choice of RSL bibliographic activity as the main object of study makes an appropriate contribution to the development of Russian theory of bibliography. The reviewer regards intensification of research activities of larger libraries (e. g. national) as an attribute of the modern theory of bibliography. The joint monograph is one of few large-scale research works covering the full range of the national library's bibliographic activities of the last century; therefore, it is of high value.
Relative energy inequality and weak-strong uniqueness for an isothermal non-Newtonian compressible fluid
Authors:   Department of Mathematical Analysis and Applications of Mathematics, Faculty of Science, Palacký University Olomouc, 17. listopadu 12, 771 46 Olomouc, Czech Republic, sik Richard Andrá ̌ , Mácha Václav ,   Institute of Mathematics of the Czech Academy of Sciences, Žitná 25, 115 67 Praha 1, Czech Republic, Vodák Rostislav ,   Department of Mathematical Analysis and Applications of Mathematics, Faculty of Science, Palacký University Olomouc, 17. listopadu 12, 771 46 Olomouc, Czech Republic
Published: June 2023

Our paper deals with three-dimensional nonsteady Navier-Stokes equations for non-Newtonian compressible fluids. It contains a de­ri­va­tion of the relative energy inequality for the weak solutions to these equations. We show that the standard energy inequality implies the relative energy inequality. Consequently, the relative energy inequality allows us to achieve a weak-strong uniqueness result. In other words, we present that the weak solution of the Navier-Stokes system coincides with the strong solution emanated from the same initial conditions as long as the strong solution exists. For this purpose, a new assumption on the coercivity of the viscous stress tensor was introduced along with two natural examples satisfying it.
Optimized bisubstrate inhibitors for the actin N-terminal acetyltransferase NAA80
Authors: Myklebust Line M. , Baumann Markus , Støve Svein I. , Foyn Håvard , Arnesen Thomas , Haug Bengt Erik 
Published: June 2023

Acetylation of protein N-termini is one of the most common protein modifications in the eukaryotic cell and is catalyzed by the N-terminal acetyltransferase family of enzymes. The N-terminal acetyltransferase NAA80 is expressed in the animal kingdom and was recently found to specifically N-terminally acetylate actin, which is the main component of the microfilament system. This unique animal cell actin processing is essential for the maintenance of cell integrity and motility. Actin is the only known substrate of NAA80, thus potent inhibitors of NAA80 could prove as important tool compounds to study the crucial roles of actin and how NAA80 regulates this by N-terminal acetylation. Herein we describe a systematic study toward optimizing the peptide part of a bisubstrate-based NAA80 inhibitor comprising of coenzyme A conjugated onto the N-terminus of a tetrapeptide amide via an acetyl linker. By testing various combinations of Asp and Glu which are found at the N-termini of β- and γ-actin, respectively, CoA-Ac-EDDI-NH2 was identified as the best inhibitor with an IC50 value of 120 nM.
High resolution monitoring of valvular interstitial cell driven pathomechanisms in procalcific environment using label-free impedance spectroscopy
Authors: Böttner Julia , Werner Sarah , Feistner Lukas , Fischer-Schaepmann Tina , Neussl Katherina , Borger Michael A. , Thiele Holger , Büttner Petra , Schlotter Florian 
Published: June 2023

IntroductionFibro-calcific aortic valve disease has high prevalence and is associated with significant mortality. Fibrotic extracellular matrix (ECM) remodeling and calcific mineral deposition change the valvular microarchitecture and deteriorate valvular function. Valvular interstitial cells (VICs) in profibrotic or procalcifying environment are frequently used in vitro models. However, remodeling processes take several days to weeks to develop, even in vitro. Continuous monitoring by real-time impedance spectroscopy (EIS) may reveal new insights into this process.MethodsVIC-driven ECM remodeling stimulated by procalcifying (PM) or profibrotic medium (FM) was monitored by label-free EIS. Collagen secretion, matrix mineralization, viability, mitochondrial damage, myofibroblastic gene expression and cytoskeletal alterations were analyzed.Results and DiscussionEIS profiles of VICs in control medium (CM) and FM were comparable. PM reproducibly induced a specific, biphasic EIS profile. Phase 1 showed an initial impedance drop, which moderately correlated with decreasing collagen secretion (r = 0.67, p = 0.22), accompanied by mitochondrial membrane hyperpolarization and cell death. Phase 2 EIS signal increase was positively correlated with augmented ECM mineralization (r = 0.97, p = 0.008). VICs in PM decreased myofibroblastic gene expression (p &lt; 0.001) and stress fiber assembly compared to CM. EIS revealed sex-specific differences. Male VICs showed higher proliferation and in PM EIS decrease in phase 1 was significantly pronounced compared to female VICs (male minimum: 7.4 ± 4.2%, female minimum: 26.5 ± 4.4%, p &lt; 0.01). VICs in PM reproduced disease characteristics in vitro remarkably fast with significant impact of donor sex. PM suppressed myofibroblastogenesis and favored ECM mineralization. In summary, EIS represents an efficient, easy-to-use, high-content screening tool enabling patient-specific, subgroup- and temporal resolution.
Opioid-related harms and care impacts of conventional and AI-based prescription management strategies: insights from leveraging agent-based modeling and machine learning
Authors: Shojaati Narjes , Osgood Nathaniel D. 
Published: June 2023

IntroductionLike its counterpart to the south, Canada ranks among the top five countries with the highest rates of opioid prescriptions. With many suffering from opioid use disorder first having encountered opioids via prescription routes, practitioners and health systems have an enduring need to identify and effectively respond to the problematic use of opioid prescription. There are strong challenges to successfully addressing this need: importantly, the patterns of prescription fulfillment that signal opioid abuse can be subtle and difficult to recognize, and overzealous enforcement can deprive those with legitimate pain management needs the appropriate care. Moreover, injudicious responses risk shifting those suffering from early-stage abuse of prescribed opioids to illicitly sourced street alternatives, whose varying dosage, availability, and the risk of adulteration can pose grave health risks.MethodsThis study employs a dynamic modeling and simulation to evaluate the effectiveness of prescription regimes employing machine learning monitoring programs to identify the patients who are at risk of opioid abuse while being treated with prescribed opioids. To this end, an agent-based model was developed and implemented to examine the effect of reduced prescribing and prescription drug monitoring programs on overdose and escalation to street opioids among patients, and on the legitimacy of fulfillments of opioid prescriptions over a 5-year time horizon. A study released by the Canadian Institute for Health Information was used to estimate the parameter values and assist in the validation of the existing agent-based model.Results and discussionThe model estimates that lowering the prescription doses exerted the most favorable impact on the outcomes of interest over 5 years with a minimum burden on patients with a legitimate need for pharmaceutical opioids. The accurate conclusion about the impact of public health interventions requires a comprehensive set of outcomes to test their multi-dimensional effects, as utilized in this research. Finally, combining machine learning and agent-based modeling can provide significant advantages, particularly when using the latter to gain insights into the long-term effects and dynamic circumstances of the former.
Multi-annual grassland mowing dynamics in Germany: spatio-temporal patterns and the influence of climate, topographic and socio-political conditions
Authors: Reinermann Sophie , Asam Sarah , Gessner Ursula , Ullmann Tobias , Kuenzer Claudia 
Published: June 2023

Introduction: Grasslands cover one third of the agricultural area in Germany and are mainly used for fodder production. However, grasslands fulfill many other ecosystem functions, like carbon storage, water filtration and the provision of habitats. In Germany, grasslands are mown and/or grazed multiple times during the year. The type and timing of management activities and the use intensity vary strongly, however co-determine grassland functions. Large-scale spatial information on grassland activities and use intensity in Germany is limited and not openly provided. In addition, the cause for patterns of varying mowing intensity are usually not known on a spatial scale as data on the incentives of farmers behind grassland management decisions is not available.Methods: We applied an algorithm based on a thresholding approach utilizing Sentinel-2 time series to detect grassland mowing events to investigate mowing dynamics in Germany in 2018–2021. The detected mowing events were validated with an independent dataset based on the examination of public webcam images. We analyzed spatial and temporal patterns of the mowing dynamics and relationships to climatic, topographic, soil or socio-political conditions.Results: We found that most intensively used grasslands can be found in southern/south-eastern Germany, followed by areas in northern Germany. This pattern stays the same among the investigated years, but we found variations on smaller scales. The mowing event detection shows higher accuracies in 2019 and 2020 (F1 = 0.64 and 0.63) compared to 2018 and 2021 (F1 = 0.52 and 0.50). We found a significant but weak (R2 of 0–0.13) relationship for a spatial correlation of mowing frequency and climate as well as topographic variables for the grassland areas in Germany. Further results indicate a clear value range of topographic and climatic conditions, characteristic for intensive grassland use. Extensive grassland use takes place everywhere in Germany and on the entire spectrum of topographic and climatic conditions in Germany. Natura 2000 grasslands are used less intensive but this pattern is not consistent among all sites.Discussion: Our findings on mowing dynamics and relationships to abiotic and socio-political conditions in Germany reveal important aspects of grassland management, including incentives of farmers.
Study on micro-mechanism of the affordable housing community in urban renewal the case of Zunyi city, Guizhou province
Authors: He Qingyan , Yang Jianzhu , Gong Lei 
Published: June 2023

Introduction: Affordable housing in China refers to housing with social security for low and middle income people under the unified planning and coordination of the government. In the process of urbanization, the construction of affordable housing and commercial housing should be developed in parallel, but under the role of the real estate market economy, the development of the two is unbalanced, resulting in a disparity in quantity, a large gap in quality, unreasonable management, and even residential segregation. The construction and development of China's affordable housing community is a huge and complex systemic project. This study focuses on a series of problems in the relationship between supply and demand of affordable housing based only on the development context of urban renewal at this stage.Methods: Based on existing literature and official data, combined with field visits and research, this study uses Vensim PLE software to build a system model for converting various types of stock into affordable housing, and to investigate the effect of various policies on solving the problem of supply and demand of affordable housing.Results: The research results show that 1) the policies stimulate the increase of urban population and help promote the supply cycle of affordable housing; 2) under the stimulation of the supply policy of converting stock housing into affordable housing, social investment will improve by 33%–64% and the gap of affordable housing will decrease by 29%–58%; 3) under the stimulation of the policy of optimizing the management of affordable housing, the coverage rate of affordable population will improve by 3%–5% and the middle and low income households’ per capita housing floor area will increase by 9%–18% l; 4) under the comprehensive influence of the combined policies, the urban population will grow healthily, the per capita income and per capita housing floor area of low- and middle- income people will be improved, the stock of housing will be reduced, the number of affordable housing will increase, the affordable housing gap will be reduced, and the affordable housing community will be developed sustainably and healthily.Meaning: The research results and recommendations will provide references for the government and competent authorities to enact or update the policies on affordable housing.
The soluble receptor for advanced glycation end products is potentially predictive of pulmonary arterial hypertension in systemic sclerosis
Authors: Atzeni Isabella M. , Al-Adwi Yehya , Doornbos-van der Meer Berber , Roozendaal Caroline , Stel Alja , van Goor Harry , Gan C. Tji , Dickinson Michael , Timens Wim , Smit Andries J. , Westra Johanna , Mulder Douwe J. 
Published: June 2023

IntroductionPulmonary arterial hypertension (PAH) and interstitial lung disease (ILD) are the leading causes of death in systemic sclerosis (SSc). Until now, no prospective biomarker to predict new onset of SSc-ILD or SSc-PAH in patients with SSc has reached clinical application. In homeostasis, the receptor for advanced glycation end products (RAGE) is expressed in lung tissue and involved in cell-matrix adhesion, proliferation and migration of alveolar epithelial cells, and remodeling of the pulmonary vasculature. Several studies have shown that sRAGE levels in serum and pulmonary tissue vary according to the type of lung-related complication. Therefore, we investigated levels of soluble RAGE (sRAGE) and its ligand high mobility group box 1 (HMGB1) in SSc and their abilities to predict SSc-related pulmonary complications.MethodsOne hundred eighty-eight SSc patients were followed retrospectively for the development of ILD, PAH, and mortality for 8 years. Levels of sRAGE and HMGB1 were measured in serum by ELISA. Kaplan-Meier survival curves were performed to predict lung events and mortality and event rates were compared with a log-rank test. Multiple linear regression analysis was performed to examine the association between sRAGE and important clinical determinants.ResultsAt baseline, levels of sRAGE were significantly higher in SSc-PAH-patients (median 4099.0 pg/ml [936.3-6365.3], p = 0.011) and lower in SSc-ILD-patients (735.0 pg/ml [IQR 525.5-1988.5], p = 0.001) compared to SSc patients without pulmonary involvement (1444.5 pg/ml [966.8-2276.0]). Levels of HMGB1 were not different between groups. After adjusting for age, gender, ILD, chronic obstructive pulmonary disease, anti-centromere antibodies, the presence of puffy fingers or sclerodactyly, use of immunosuppression, antifibrotic therapy, or glucocorticoids, and use of vasodilators, higher sRAGE levels remained independently associated with PAH. After a median follow-up of 50 months (25-81) of patients without pulmonary involvement, baseline sRAGE levels in the highest quartile were predictive of development of PAH (log-rank p = 0.01) and of PAH-related mortality (p = 0.001).ConclusionsHigh systemic sRAGE at baseline might be used as a prospective biomarker for patients with SSc at high risk to develop new onset of PAH. Moreover, high sRAGE levels could predict lower survival rates due to PAH in patients with SSc.
Novel microRNAs modulating ecto-5′-nucleotidase expression
Authors: Kordaß Theresa , Chao Tsu-Yang , Osen Wolfram , Eichmüller Stefan B. 
Published: June 2023

IntroductionThe expression of immune checkpoint molecules (ICMs) by cancer cells is known to counteract tumor-reactive immune responses, thereby promoting tumor immune escape. For example, upregulated expression of ecto-5′-nucleotidase (NT5E), also designated as CD73, increases extracellular levels of immunosuppressive adenosine, which inhibits tumor attack by activated T cells. MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression at the post-transcriptional level. Thus, the binding of miRNAs to the 3′-untranslated region of target mRNAs either blocks translation or induces degradation of the targeted mRNA. Cancer cells often exhibit aberrant miRNA expression profiles; hence, tumor-derived miRNAs have been used as biomarkers for early tumor detection.MethodsIn this study, we screened a human miRNA library and identified miRNAs affecting the expression of ICMs NT5E, ENTPD1, and CD274 in the human tumor cell lines SK-Mel-28 (melanoma) and MDA-MB-231 (breast cancer). Thereby, a set of potential tumor-suppressor miRNAs that decreased ICM expression in these cell lines was defined. Notably, this study also introduces a group of potential oncogenic miRNAs that cause increased ICM expression and presents the possible underlying mechanisms. The results of high-throughput screening of miRNAs affecting NT5E expression were validated in vitro in 12 cell lines of various tumor entities.ResultsAs result, miR-1285-5p, miR-155-5p, and miR-3134 were found to be the most potent inhibitors of NT5E expression, while miR-134-3p, miR-6859-3p, miR-6514-3p, and miR-224-3p were identified as miRNAs that strongly enhanced NT5E expression levels.DiscussionThe miRNAs identified might have clinical relevance as potential therapeutic agents and biomarkers or therapeutic targets, respectively.