bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of a previous late miscarriage on subsequent pregnancy outcomes: A retrospective cohort study over 10 years
Authors: Yang Linlin , Ni Tianxiang , Huang Yumei , Yan Yueyue , Xia Mingdi , Zhou Wei , Zhang Qian , Yan Junhao 
Published: May 2023

AbstractObjectiveTo explore the prognostic impact of a previous late miscarriage (LM) on the subsequent pregnancy outcomes of women with infertility.MethodThis retrospective cohort study included couples who had experienced LM following their first embryo transfer during an in vitro fertilization (IVF) cycle from January 2008 to December 2020. Subgroup analysis and binary logistic regression were performed to evaluate the associations between LM due to different causes and subsequent pregnancy outcomes.ResultsA total of 1072 women who had experienced LM were included in this study, comprising 458, 146, 412, and 56 women with LM due to unexplained factors (unLM), fetal factors (feLM), cervical factors (ceLM; i.e. cervical incompetence), and trauma factors (trLM), respectively. Compared with the general IVF (gIVF) population, the early miscarriage rate was significantly higher in the unLM group (8.28% vs. 13.47%, adjusted odds ratio [OR] 1.60, 95% confidence interval [95% CI] 1.12–2.28; P = 0.01). Furthermore, women in the unLM and ceLM groups had a dramatically increased risk of recurrent LM (unLM: 4.24% vs. 9.43%, aOR 1.91, 95% CI 1.24–2.94; P = 0.003; ceLM: 4.24% vs.15.53%, aOR 2.68, 95% CI 1.82–3.95; P < 0.001) and consequently a reduced frequency of live birth (unLM: 49.96% vs. 43.01%, aOR 0.75, 95% CI 0.61–0.91; P = 0.004; ceLM: 49.96% vs. 38.59%, aOR 0.61, 95% CI 0.49–0.77; P < 0.001) compared with the gIVF population.ConclusionA previous LM due to an unexplained factor or cervical incompetence was significantly associated with a higher risk of miscarriage and a lower live birth rate after subsequent embryo transfer.
Homeless people's recovery in Housing First and Traditional Services: The role of working alliance in Italian housing services
Authors: Curiale Chiara , Lenzi Michela , Gaboardi Marta , Marino Claudia , Ronconi Lucia , Demita Silvia , Cosentino Roberta , Disperati Francesca , Santinello Massimo 
Published: May 2023

AbstractThis study aims to investigate whether a working alliance could represent a potential mechanism that explains the effectiveness of housing services in terms of user recovery, comparing the Housing First (HF) model with Traditional Services (TS). This study included 59 homeless service users in Italy (29 = HF; 30 = TS). Recovery was assessed upon entering the study (T0) and after 10 months (T1). Results indicate that participants inserted in HF services were more likely to report stronger working alliances with social service providers at T0 that, in turn, was directly associated with higher levels of users' recovery at the beginning of the study and indirectly (through recovery at T0) with recovery at T1. Implications of the results are discussed with respect to research and practice on homeless services.
Androgen receptor coordinates muscle metabolic and contractile functions
Authors: Ghaibour Kamar , Schuh Mélanie , Souali‐Crespo Sirine , Chambon Céline , Charlot Anouk , Rizk Joe , Rovito Daniela , Rerra Anna‐Isavella , Cai Qingshuang , Messaddeq Nadia , Zoll Joffrey , Duteil Delphine , Metzger Daniel 
Published: May 2023

AbstractBackgroundAndrogens are anabolic steroid hormones that exert their function by binding to the androgen receptor (AR). We have previously established that AR deficiency in limb muscles impairs sarcomere myofibrillar organization and decreases muscle strength in male mice. However, despite numerous studies performed in men and rodents, the signalling pathways controlled by androgens via their receptor in skeletal muscles remain poorly understood.MethodsMale ARskm−/y (n = 7–12) and female ARskm−/− mice (n = 9), in which AR is selectively ablated in myofibres of musculoskeletal tissue, and male AR(i)skm−/y, in which AR is selectively ablated in post‐mitotic skeletal muscle myofibres (n = 6), were generated. Longitudinal monitoring of body weight, blood glucose, insulin, lipids and lipoproteins was performed, alongside metabolomic analyses. Glucose metabolism was evaluated in C2C12 cells treated with 5α‐dihydrotestosterone (DHT) and the anti‐androgen flutamide (n = 6). Histological analyses on macroscopic and ultrastructural levels of longitudinal and transversal muscle sections were conducted. The transcriptome of gastrocnemius muscles from control and ARskm−/y mice was analysed at the age of 9 weeks (P < 0.05, 2138 differentially expressed genes) and validated by RT‐qPCR analysis. The AR (4691 peaks with false discovery rate [FDR] < 0.1) and H3K4me2 (47 225 peaks with FDR < 0.05) cistromes in limb muscles were determined in 11‐week‐old wild‐type mice.ResultsWe show that disrupting the androgen/AR axis impairs in vivo glycolytic activity and fastens the development of type 2 diabetes in male, but not in female mice. In agreement, treatment with DHT increases glycolysis in C2C12 myotubes by 30%, whereas flutamide has an opposite effect. Fatty acids are less efficiently metabolized in skeletal muscles of ARskm−/y mice and accumulate in cytoplasm, despite increased transcript levels of genes encoding key enzymes of beta‐oxidation and mitochondrial content. Impaired glucose and fatty acid metabolism in AR‐deficient muscle fibres is associated with 30% increased lysine and branched‐chain amino acid catabolism, decreased polyamine biosynthesis and disrupted glutamate transamination. This metabolic switch generates ammonia (2‐fold increase) and oxidative stress (30% increased H2O2 levels), which impacts mitochondrial functions and causes necrosis in <1% fibres. We unravel that AR directly activates the transcription of genes involved in glycolysis, oxidative metabolism and muscle contraction.ConclusionsOur study provides important insights into diseases caused by impaired AR function in musculoskeletal system and delivers a deeper understanding of skeletal muscle pathophysiological dynamics that is instrumental to develop effective treatment for muscle disorders.
Muscle size and density are independently associated with death after hip fracture: A prospective cohort study
Authors: Wang Ling , Yang Minghui , Ge Yufeng , Liu Yandong , Su Yongbin , Guo Zhe , Huang Pengju , Geng Jian , Wang Gang , Blake Glen M. , He Bo , Yin Lu , Cheng Xiaoguang , Wu Xinbao , Engelke Klaus , Vlug Annegreet G. 
Published: May 2023

AbstractBackgroundMortality following hip fracture is high and incompletely understood. We hypothesize that hip musculature size and quality are related to mortality following hip fracture. This study aims to investigate the associations of hip muscle area and density from hip CT with death following hip fracture as well as assess the dependence of this association on time after hip fracture.MethodsIn this secondary analysis of the prospectively collected CT images and data from the Chinese Second Hip Fracture Evaluation, 459 patients were enrolled between May 2015 and June 2016 and followed up for a median of 4.5 years. Muscle cross‐sectional area and density were measured of the gluteus maximus (G.MaxM) and gluteus medius and minimus (G.Med/MinM) and aBMD of the proximal femur. The Goutallier classification (GC) was used for qualitatively assessing muscle fat infiltration. Separate Cox models were used to predict mortality risk adjusted for covariates.ResultsAt the end of the follow‐up, 85 patients were lost, 81 patients (64% women) had died, and 293 (71% women) survived. The mean age of non‐surviving patients at death (82.0 ± 8.1 years) was higher than that of the surviving patients (74.4 ± 9.9 years). The Parker Mobility Score and the American Society of Anesthesiologists scores of the patients that died were respectively lower and higher compared to the surviving patients. Hip fracture patients received different surgical procedures, and no significant difference in the percentage of hip arthroplasty was observed between the dead and the surviving patients (P = 0.11). The cumulative survival was significantly lower for patients with low G.MaxM area and density and low G.Med/MinM density, independent of age and clinical risk scores. The GC grades were not associated with the mortality after hip fracture. Muscle density of both G.MaxM (adj. HR 1.83; 95% CI, 1.06–3.17) and G.Med/MinM (adj. HR 1.98; 95% CI, 1.14–3.46) was associated with mortality in the 1st year after hip fracture. G.MaxM area (adj. HR 2.11; 95% CI, 1.08–4.14) was associated with mortality in the 2nd and later years after hip fracture.ConclusionOur results for the first time show that hip muscle size and density are associated with mortality in older hip fracture patients, independent of age and clinical risk scores. This is an important finding to better understand the factors contributing to the high mortality in older hip fracture patients and to develop better future risk prediction scores that include muscle parameters.
Association of muscle wasting with mortality risk among adults: A systematic review and meta‐analysis of prospective studies
Authors: Zhou Huan‐Huan , Liao Yuxiao , Peng Zhao , Liu Fang , Wang Qi , Yang Wei 
Published: May 2023

AbstractThe relationship between muscle wasting and mortality risk in the general population remains unclear. Our study was conducted to examine and quantify the associations between muscle wasting and all‐cause and cause‐specific mortality risks. PubMed, Web of Science and Cochrane Library were searched until 22 March 2023 for main data sources and references of retrieved relevant articles. Prospective studies investigating the associations of muscle wasting with risks of all‐cause and cause‐specific mortality in the general population were eligible. A random‐effect model was used to calculate the pooled relative risk (RR) and 95% confidence intervals (CIs) for the lowest versus normal categories of muscle mass. Subgroup analyses and meta‐regression were performed to investigate the potential sources of heterogeneities among studies. Dose–response analyses were conducted to evaluate the relationship between muscle mass and mortality risk. Forty‐nine prospective studies were included in the meta‐analysis. A total of 61 055 deaths were ascertained among 878 349 participants during the 2.5‐ to 32‐year follow‐up. Muscle wasting was associated with higher mortality risks of all causes (RR = 1.36, 95% CI, 1.28 to 1.44, I2 = 94.9%, 49 studies), cardiovascular disease (CVD) (RR = 1.29, 95% CI, 1.05 to 1.58, I2 = 88.1%, 8 studies), cancer (RR = 1.14, 95% CI, 1.02 to 1.27, I2 = 38.7%, 3 studies) and respiratory disease (RR = 1.36, 95% CI, 1.11 to 1.67, I2 = 62.8%, 3 studies). Subgroup analyses revealed that muscle wasting, regardless of muscle strength, was significantly associated with a higher all‐cause mortality risk. Meta‐regression showed that risks of muscle wasting‐related all‐cause mortality (P = 0.06) and CVD mortality (P = 0.09) were lower in studies with longer follow‐ups. An approximately inverse linear dose–response relationship was observed between mid‐arm muscle circumference and all‐cause mortality risk (P < 0.01 for non‐linearity). Muscle wasting was associated with higher mortality risks of all causes, CVD, cancer and respiratory disease in the general population. Early detection and treatment for muscle wasting might be crucial for reducing mortality risk and promoting healthy longevity.
Developing time management with preclinical dental students via a preclinical exercise in an organization
Authors: Patterson Rita C , Jones Jeffrey R 
Published: May 2023

AbstractPurpose/objectivesDeveloping time management is an important aspect of a dental student's passage to clinical care and in their growth as a professional. Suitable time management and preparedness can potentially impact the prognosis of a successful dental appointment. The objective of this study was to determine if a time management exercise could be effective to increase students’ preparedness, organization, time management, and reflection during simulated clinical care prior to transitioning to the dental clinic.MethodsStudents completed five‐time management exercises during the term preceding their entrance into the predoctoral restorative clinic which included appointment planning and organization, and reflection once finished. Pre‐ and post‐term surveys were used to determine the impact of the experience. Quantitative data was analyzed using a paired t‐test and the qualitative data was thematically coded by the researchers.ResultsStudents reported a statistically significant increase in their self‐confidence of clinical readiness after completion of the time management series, and all students completed the surveys. The themes indicated by students through their comments in the post‐survey question regarding the experience were as follows: planning and preparation, time management, the practice of procedures, concern about workload, faculty encouragement, and unclear. Most students also reported the exercise to be beneficial for their predoctoral clinical appointments.ConclusionsIt was determined that the time management exercises were effective for the students as they transitioned to treating patients in the predoctoral clinic and can be used for future classes to increase their success.
Expression pattern of long non‐coding RNAs MALAT1 and MEG3 in COVID‐19 patients
Authors: Genena Shaimaa El Sayed Ramadan , Fadhil Maher Mishaal , Mansour Manal Monir , Attwa Asrar Helal Mahrous , Khalil Marwa Mohammed Ibrahim Mohammed 
Published: May 2023

AbstractBackgroundCOVID‐19 is a novel infectious disease for which no specific treatment exists. It is likely that a combination of genetic and non‐genetic factors predispose to it. Expression levels of genes that are involved in the interaction with SARS‐CoV‐2 or the host response are thought to play a role in disease susceptibility and severity. It is crucial to explore biomarkers for disease severity and outcome. Herein, we studied the expression levels and effects of long non‐coding metastasis‐associated lung adenocarcinoma transcript 1 (lnc‐MALAT1) and long non‐coding maternally expressed gene 3 (lnc‐MEG3) in COVID‐19 patients. The study enrolled 35 hospitalized and 35 non‐hospitalized COVID‐19 patients, and 35 healthy controls. A chest computed tomography (CT) scan, complete blood count (CBC), ferritin, C‐reactive protein (CRP), D‐dimer and analysis of lnc‐MALAT1 and lnc‐MEG3 expression were done.ResultsThere was a significant relation between ferritin, CRP, D‐dimer levels, oxygen saturation, CT‐CORADS score and disease severity. Lnc‐MALAT1 was significantly higher but lnc‐MEG3 was significantly lower in patients vs. controls, and in hospitalized vs. non‐hospitalized patients. Elevated MALAT1 and reduced MEG3 levels were significantly associated with more elevated ferritin, CRP, D‐dimer levels, lower oxygen saturation, higher CT‐CORADS score and poor survival. Moreover, MALAT1 and MEG3 levels displayed higher sensitivity and specificity as predictors of COVID‐19 severity compared with other prognostic biochemical markers such as ferritin, CRP, and D‐dimer.ConclusionsMALAT1 levels are higher, whereas MEG3 levels are lower in COVID‐19 patients. Both are linked to disease severity and mortality and could emerge as predictive biomarkers for COVID‐19 severity and therapeutic targets.
Synthesis, spectral characteristics and molecular structure of 2H‐1,3,5‐oxadiazine‐2,4(3H)‐diimine derivatives
Authors: Pokotylo Ihor O. , Zadorozhnii Pavlo V. , Kiselev Vadym V. , Kharchenko Aleksandr V. 
Published: May 2023

AbstractIn this work, we report the synthesis of 2H‐1,3,5‐oxadiazine‐2,4(3H)‐diimine derivatives based on acylated thioureas. The method for the preparation of 1,3,5‐oxadiazine derivatives is based on the reaction of dehydrosulfurization of the starting acylated thioureas under the action of dicyclohexylcarbodiimide (DCC) followed by the [4 + 2] cycloaddition reaction of another DCC molecule to the resulting intermediate carbodiimide. The structure of the obtained derivatives of 1,3,5‐oxadiazine was confirmed by 1H, 13C NMR, IR spectroscopy, mass spectrometry, and x‐ray diffraction analysis.
Feeling safe versus being safe: Perceptions of safety versus actual disease exposure across the entire health care team
Authors: Boitet Laurence M. , Meese Katherine A. , Colón‐López Alejandra , Sweeney Katherine L. , Rogers David A. 
Published: May 2023

AbstractAs supply chains experienced disruptions early in the COVID‐19 pandemic, personal protective equipment (PPE) quickly became scarce. The purpose of this study was to examine the impact of perceptions of inadequate PPE, fear of COVID‐19 infection, and self‐reported direct COVID‐19 exposure on health care workers. Data to assess distress, resilience, social‐ecological factors, and work and nonwork‐related stressors were collected from June to July 2020 at a large medical center. Stressors were analyzed by role using descriptive statistics and multivariate regression analysis. Our data indicate that job role influenced fear of infection and perceptions of inadequate PPE in the early phase of the COVID‐19 pandemic. Perceived organizational support was also related to perceptions of inadequate PPE supply. Interestingly, work location, rather than job role, was predictive of direct COVID‐19 exposure. Our data highlight a disconnect between the perception of safety in the health care setting with real risk of exposure to infectious disease. This study suggests that leaders in health care should focus on cultivating supportive organizational cultures, assessing both perceived and actual safety, and provide adequate training in safety practices may improve preparedness and organizational trust during times of both certainty and crisis particularly for clinical workers with less education and training.
Tomoelastography and Pancreatic Extracellular Volume Fraction Derived From MRI for Predicting Clinically Relevant Postoperative Pancreatic Fistula
Authors: Zhu Liang , Sun Zhaoyong , Dai Menghua , Wu Huanwen , Wang Xuan , Xu Jia , Xue Huadan , Jin Zhengyu , Nickel Marcel Dominik , Guo Jing , Sack Ingolf 
Published: May 2023

BackgroundPancreatic stiffness and extracellular volume fraction (ECV) are potential imaging biomarkers for pancreatic fibrosis. Clinically relevant postoperative fistula (CR‐POPF) is one of the most severe complications after pancreaticoduodenectomy. Which imaging biomarker performs better for predicting the risk of CR‐POPF remains unknown.PurposeTo evaluate the diagnostic performance of ECV and tomoelastography‐derived pancreatic stiffness for predicting the risk of CR‐POPF in patients undergoing pancreaticoduodenectomy.Study typeProspective.PopulationEighty patients who underwent multiparametric pancreatic MRI before pancreaticoduodenectomy, among whom 16 developed CR‐POPF and 64 did not.Field Strength/Sequence3 T/tomoelastography and precontrast and postcontrast T1 mapping of the pancreas.AssessmentPancreatic stiffness was measured on the tomographic c‐map, and pancreatic ECV was calculated from precontrast and postcontrast T1 maps. Pancreatic stiffness and ECV were compared with histological fibrosis grading (F0‐F3). The optimal cutoff values for predicting CR‐POPF were determined, and the correlation between CR‐POPF and imaging parameters was evaluated.Statistical testsThe Spearman's rank correlation and multivariate linear regression analysis was conducted. The receiver operating characteristic curve analysis and logistic regression analysis was performed. A double‐sided P < 0.05 indicated a statistically significant difference.ResultsPancreatic stiffness and ECV both showed a significantly positive correlation with histological pancreatic fibrosis (r = 0.73 and 0.56, respectively). Patients with advanced pancreatic fibrosis had significantly higher pancreatic stiffness and ECV compared to those with no/mild fibrosis. Pancreatic stiffness and ECV were also correlated with each other (r = 0.58). Lower pancreatic stiffness (<1.38 m/sec), lower ECV (<0.28), nondilated main pancreatic duct (<3 mm) and pathological diagnosis other than pancreatic ductal adenocarcinoma were associated with higher risk of CR‐POPF at univariate analysis, and pancreatic stiffness was independently associated with CR‐POPF at multivariate analysis (odds ratio: 18.59, 95% confidence interval: 4.45, 77.69).Data ConclusionPancreatic stiffness and ECV were associated with histological fibrosis grading, and pancreatic stiffness was an independent predictor for CR‐POPF.Level of Evidence1Technical Efficacy Stage5
Anti‐EBV antibodies: Roles in diagnosis, pathogenesis, and antiviral therapy
Authors: Xie Chu , Zhong Lan‐Yi , Bu Guo‐Long , Zhao Ge‐Xin , Yuan Bo‐Yu , Liu Yuan‐Tao , Sun Cong , Zeng Mu‐Sheng 
Published: May 2023

AbstractEpstein‐Barr virus (EBV) infection is prevalent in global population and associated with multiple malignancies and autoimmune diseases. During the infection, EBV‐harbored or infected cell‐expressing antigen could elicit a variety of antibodies with significant role in viral host response and pathogenesis. These antibodies have been extensively evaluated and found to be valuable in predicting disease diagnosis and prognosis, exploring disease mechanisms, and developing antiviral agents. In this review, we discuss the versatile roles of EBV antibodies as important biomarkers for EBV‐related diseases, potential driving factors of autoimmunity, and promising therapeutic agents for viral infection and pathogenesis.
2023 HRS/APHRS/LAHRS guideline on cardiac physiologic pacing for the avoidance and mitigation of heart failure
Authors: Chung Mina K. , Patton Kristen K. , Lau Chu‐Pak , Dal Forno Alexander R. J. , Al‐Khatib Sana M. , Arora Vanita , Birgersdotter‐Green Ulrika Maria , Cha Yong‐Mei , Chung Eugene H. , Cronin Edmond M. , Curtis Anne B. , Cygankiewicz Iwona , Dandamudi Gopi , Dubin Anne M. , Ensch Douglas P. , Glotzer Taya V. , Gold Michael R. , Goldberger Zachary D. , Gopinathannair Rakesh , Gorodeski Eiran Z. , Gutierrez Alejandra , Guzman Juan C. , Huang Weijian , Imrey Peter B. , Indik Julia H. , Karim Saima , Karpawich Peter P. , Khaykin Yaariv , Kiehl Erich L. , Kron Jordana , Kutyifa Valentina , Link Mark S. , Marine Joseph E. , Mullens Wilfried , Park Seung‐Jung , Parkash Ratika , Patete Manuel F. , Pathak Rajeev Kumar , Perona Carlos A. , Rickard John , Schoenfeld Mark H. , Seow Swee‐Chong , Shen Win‐Kuang , Shoda Morio , Singh Jagmeet P. , Slotwiner David J. , Sridhar Arun Raghav M. , Srivatsa Uma N. , Stecker Eric C. , Tanawuttiwat Tanyanan , Tang W. H. Wilson , Tapias Carlos Andres , Tracy Cynthia M. , Upadhyay Gaurav A. , Varma Niraj , Vernooy Kevin , Vijayaraman Pugazhendhi , Worsnick Sarah Ann , Zareba Wojciech , Zeitler Emily P. ,   Document Reviewers, Lopez‐Cabanillas Nestor , Ellenbogen Kenneth A. , Hua Wei , Ikeda Takanori , Mackall Judith A. , Mason Pamela K. , McLeod Christopher J. , Mela Theofanie , Moore Jeremy P. , Racenet Laurel Kay 
Published: May 2023

AbstractCardiac physiologic pacing (CPP), encompassing cardiac resynchronization therapy (CRT) and conduction system pacing (CSP), has emerged as a pacing therapy strategy that may mitigate or prevent the development of heart failure (HF) in patients with ventricular dyssynchrony or pacing‐induced cardiomyopathy. This clinical practice guideline is intended to provide guidance on indications for CRT for HF therapy and CPP in patients with pacemaker indications or HF, patient selection, pre‐procedure evaluation and preparation, implant procedure management, follow‐up evaluation and optimization of CPP response, and use in pediatric populations. Gaps in knowledge, pointing to new directions for future research, are also identified.