bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relationship of Serum Trimethylamine N-Oxide Levels With Carotid Intima-Media Thickness and Disease Activity in Psoriasis Patients
Authors: Zekey Emre , Tunçez Akyürek Fatma Tunçez Akyürek , Tunçez Abdullah , Akyürek Fikret , Doğan Merve Ezgi 
Published: April 2023

Introduction: Psoriasis is an inflammatory disease that can cause cardiovascular comorbidities. Some recent studies have indicated that impaired gut microbiota and metabolites may be associated with inflammatory diseases.
Objectives: In this study, the relationship between serum trimethylamine n-oxide (TMAO, a gut bacterial metabolite) level and carotid intima-media thickness (CIMT) and disease severity in psoriasis patients was investigated.
Methods: Age- and gender-matched 73 patients and 72 healthy controls were included in the study. In both groups serum trimethylamine n-oxide(TMAO), oxidized low- density lipoprotein (ox-LDL), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglyceride, total cholesterol, high-sensitivity C-reactive protein (hs-CRP), creatinine, aspartate aminotransferase (AST) and alanine aminotransferase(ALT) levels were recorded and the carotid intima-media thickness (CIMT) was measured by B-mode ultrasonography by a cardiologist.

Results: TMAO, hs-CRP, oxidized-LDL, triglyceride and CIMT levels were statistically higher in the patient group. HDL levels were statistically higher in the control group. There was no significant difference between the two groups in terms of total cholesterol and LDL-C levels. In partial correlation analyzes in the patient group, positive correlations were observed between TMAO and CIMT, LDL-C and total cholesterol levels. Linear regression analysis showed that TMAO levels positively predicted CIMT levels.
Conclusions: This study confirmed that psoriasis is a risk factor for the development of cardiovascular disease and that elevated serum TMAO levels in these patients indicate the presence of intestinal dysbiosis. Furthermore, TMAO levels were found to be a predictor of the risk of developing cardiovascular disease in psoriasis patients.
The Use of New Hematological Markers in the Diagnosis of Alopecia Areata
Authors: Aksoy Sarac Gulhan , Acar Onur , Nayır Tufan , Hararcı Yıldırım Pınar , Dincer Rota Didem 
Published: April 2023

Introduction: Alopecia areata (AA) is a non-cicatricial inflammatory and autoimmune hair loss disease. In recent studies, it has been reported that hematological parameters can be used as oxidative stress markers in the diagnosis of many inflammatory diseases due to their low cost and widespread use.
Objectives: In this study, it was aimed to reveal the significant cut-off points of hematological inflammatory markers in AA that can guide clinicians in clinical practice and determine how many times they increase the risk of disease.
Methods: The present study is retrospective case-control type. Seventy patients with AA and seventy healthy controls were included in the study. The hematological parameters in both groups were evaluated retrospectively.
Results: Hemoglobulin, monocyte, platelet, monocyte high-density lipoprotein cholesterol (HDL-C) ratio (MHR), monocyte lymphocyte ratio (MLR), platelet lymphocyte ratio (PLR) were high in patients with AA, while the number of lymphocytes was low. In ROC analysis, the optimal cut-off values for the diagnosis of AA were as follows: MLR 0.216, MHR 0.010, and PLR 111.715. In regression analysis, being above the following values of MLR 0.216, MHR 0.010, and PLR 111.715 increased the risk of developing AA by 6.3, 3.8, and 2.7 times, respectively.
Conclusions: It was seen that MHR and PLR, especially MLR, can significantly increase the risk of developing the disease in AA and can also be used as diagnostic markers.
Scabies Affects Quality of Life in Correlation with Depression and Anxiety
Authors: Koç Yıldırım Sema , Demirel Öğüt Neslihan , Erbağcı Ece , Öğüt Çağrı 
Published: April 2023

Introduction: Scabies is a highly contagious disease affects many people worldwide each year and a major public health problem. A small number of studies have shown that scabies causes impairment in the quality of life in adult patients.
Objectives: The aims of this study are to assess the impact of scabies on adult patients quality of life (QoL) and evaluate the relationship between depression and anxiety levels and impairment in life quality.
Methods: This cross-sectional study included adult patients diagnosed with scabies in our dermatology outpatient clinic. The effect of scabies on QoL was evaluated by Dermatology Life Quality Index (DLQI), and the levels of depression and anxiety were evaluated by Beck Depression Scale (BDS) and Beck Anxiety Scale (BAS).
Results: Totally, 85 patients included to the study. QoL of 72.2% of the patients was moderate to extremely large affected. There was a positive correlation between the duration of the disease, the total DLQI score and the severity of the disease impact on QoL (rs= 0.287, P = 0.01 and rs=0.280, P = 0.008, respectively). A positive correlation was found between the number of treatments received and the total DLQI (rs= 0.223, P = 0.042). There was a positive correlation between BDS and BAS, and total DLQI score (rs=0.448 and P = 0.000; rs=0.456 and P = 0.000, respectively).
Conclusions: Scabies has a moderate to severe effect on QoL. There was a positive correlation between impairment QoL and anxiety and depression scores.
Psychosocial Implications and Quality of Life in Patients with Hidradenitis Suppurativa Compared to Those With Atopic Dermatitis and Psoriasis: a Cross-sectional Case-control Study
Authors: AlSiyoufi Alya , Almohaimeed Saleh , Alsiyoufi Sawsan , Salah Louai 
Published: April 2023

Introduction: Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease that has been reported to have the greatest negative impact on quality of life (QoL) and psychosocial factors when compared with other skin conditions.Objectives: To assess psychosocial impact and QoL impairment in patients with HS.Methods: This cross-sectional case-control study included a case group with HS and a control group with psoriasis or atopic dermatitis diagnosed by a dermatologist at a public hospital in Jeddah, Saudi Arabia from 2016 to 2019. Data were obtained from medical records at a ratio of 1:2. Patients were contacted via telephone and asked to complete Arabic-validated questionnaires (Dermatology Life Quality Index [DLQI], Rosenberg Self-Esteem Scale, and Hospital Anxiety and Depression Scale) and a survey containing pictures to identify Hurley stage.Results: The study included 46 patients and 101 controls (eczema, 50; psoriasis, 51). Patients had significantly higher DLQI and depression scores than did controls (P < 0.05). Anxiety and depression scores were significantly higher in women than men (P < 0.05). Cases with Hurley stage 3 had significantly higher DLQI scores than those with Hurley stages 1 and 2. Controls had a significantly higher percentage of employed participants (P < 0.05).Conclusions: HS had a greater psychosocial impact on QoL than psoriasis or atopic dermatitis and was associated with a lower employment rate. Women were more affected by the disease than men. Therefore, we recommend paying close attention to the psychosocial aspects of the disease and establishing educational programs and support groups for patients with HS.
Manajemen Sumber Daya Manusia
Authors: Cipta Alung 
Published: April 2023

Buku ini disusun oleh akademisi dan praktisi sesuai dengan kepakarannya masing-masing. Buku ini diharapkan dapat hadir memberikan kontribusi positif dalam ilmu pengetahuan khususnya Manajemen Sumber Daya Manusia yang merujuk kepada keilmuan bidang Manajemen. Luasnya permasalahan di bidang sumber daya manusia (SDM) mengharuskan organisasi membatasi ruang gerak dan aktivitasnya pada aspek-aspek penting dari manajemen sumber daya manusia itu sendiri. Oleh karena itu, pada penyusunan buku ini akan diuraikan masalah-masalah pokok dalam SDM dan batasan-batasannya. Dengan memahami proses dalam manajemen sumber daya manusia, pembaca khususnya mahasiswa S1 sebagai target dari buku ini diharapkan dapat merumuskan sebuah konsep utama dalam MSDM. Pada pendidikan strata satu (S1), pengajaran Manajemen Sumber Daya Manusia bertujuan memberikan dasar kemampuan bagi mahasiswa untuk menyusun proses perencanaan dan pengembangan sumber daya manusia.
Fundamentals of Soil Science
Authors: Rajan Raja A. 
Published: April 2023

Soil is a finite resource and its loss and degradation is not recoverable within a human lifespan. Soils affect the food we eat, the water we drink, the air we breathe and our overall health and the health of all organisms on the planet. Without healthy soils, we would not be able to grow our food, or meet our fibre and fodder requirements. It is estimated that 95 per cent of our food is directly or indirectly produced on our soils. The book provides the basic understanding of the soil, its nature, properties and functions. It has been attempted to present in a logical sequence all basic information about soils, from the definition of soil to how they are formed, the factors and processes governing their formation, their intrinsic properties, classification, functions, and the role they play in the global environment today and for a sustainable tomorrow. Emphasis on soil quality and soil health care has been laid as it is the order of the day. The 32 chapters of the book will provide a wealth of information for those looking to take their first deep dive into the realm of soils.
ĐÁNH GIÁ HÀNH VI TỰ CHĂM SÓC CỦA 384 BỆNH NHÂN ĐÁI THÁO ĐƯỜNG TÍP 2, ĐIỀU TRỊ NGOẠI TRÚ TẠI KHOA KHÁM BỆNH, BỆNH VIỆN TIM HÀ NỘI
Authors: Nguyễn Thị Hà  , Lê Thị Bình  
Published: April 2023

TÓM TẮT:
Mục tiêu: Đánh giá thực trạng hành vi tự chăm sóc của bệnh nhân đái tháo đường típ 2.
Đối tượng và phương pháp: Nghiên cứu mô tả cắt ngang 384 bệnh nhân đái tháo đường típ 2, điều trị ngoại trú tại Khoa Khám bệnh, Bệnh viện Tim Hà Nội, từ tháng 8-12/2022.
Kết quả: Bệnh nhân trung bình 68,09 ± 9,23 tuổi, nữ giới (54,9%) nhiều hơn nam giới (45,1%). Đa số là bệnh nhân hưu trí (61,7%), thừa cân/béo phì (51,8%), thời gian mắc bệnh từ 5 năm trở lên (58,5%), điều trị đái tháo đường bằng thuốc viên (81,3%). Có 10,7% bệnh nhân tiêm insulin; 8,1% bệnh nhân tiêm insulin kết hợp uống thuốc viên. Về hành vi tự chăm sóc: 72,7% bệnh nhân tự chăm sóc tốt về chế độ ăn, tiết chế; 78,1% bệnh nhân tự chăm sóc tốt về vận động thể chất; 96,9% bệnh nhân tự dùng thuốc tốt. Tỉ lệ bệnh nhân tự chăm sóc bàn chân chưa tốt chiếm 84,9%. Đánh giá chung: 41,1% bệnh nhân tự chăm sóc tốt, 58,9% bệnh nhân tự chăm sóc chưa tốt. Mối liên quan: bệnh nhân đang không có vợ/chồng thì tự chăm sóc chung chưa tốt cao hơn so với bệnh nhân đang có vợ/chồng; bệnh nhân mắc bệnh dưới 5 năm thì tự chăm sóc chung chưa tốt cao hơn so với bệnh nhân mắc bệnh từ 5 năm trở lên; bệnh nhân mắc tăng huyết áp kèm theo thì tự chăm sóc chung chưa tốt cao hơn so với bệnh nhân không mắc tăng huyết áp; sự khác biệt có ý nghĩa thống kê với p < 0,05.
Từ khóa: Bệnh nhân, đái tháo đường.
NGHIÊN CỨU KẾT QUẢ ĐIỀU TRỊ TRĨ NỘI BẰNG PHƯƠNG PHÁP THẮT VÒNG CAO SU QUA NỘI SOI HẬU MÔN ỐNG CỨNG TẠI BỆNH VIỆN QUÂN Y 7
Authors: Phạm Văn Dũng  , Nguyễn Văn Chuyên  , Hoàng Văn Lý  , Đào Thị Phượng  
Published: April 2023

Mục tiêu: Mô tả đặc điểm lâm sàng và đánh giá kết quả điều trị trĩ nội bằng phương pháp thắt vòng cao su qua nội soi hậu môn ống cứng.
Đối tượng, phương pháp: Nghiên cứu tiến cứu, can thiệp không đối chứng 33 bệnh nhân trĩ nội (từ độ I đến độ III), khám và điều trị tại Bệnh viện Quân y 7, từ tháng 4/2021 đến tháng 8/2022.
Kết quả: Bệnh nhân trung bình 55,91 ± 11,3 tuổi; tỉ lệ nam giới (66,7%) nhiều hơn nữ giới (33,3%). Triệu chứng lâm sàng hay gặp là đi ngoài ra máu (66,7%) và tiết dịch hậu môn (57,6%). Đa số bệnh nhân trĩ nội độ II (60,6%); số lần thắt vòng cao su trung bình là 1,06 ± 0,24 lần; tỉ lệ bệnh nhân thắt 2 vòng là 75,7%. Sau thắt trĩ, có 84,8% bệnh nhân đau tức hậu môn, 36,4% bệnh nhân đi ngoài phân dính máu. Sau thắt búi trĩ 4-6 tuần, tỉ lệ bệnh nhân có triệu chứng đi ngoài ra máu giảm từ 66,7% xuống còn 15,2% và điểm trung bình chất lượng cuộc sống (0,962 ± 0,042 điểm) cao hơn so với trước điều trị (0,855 ± 0,062 điểm), khác biệt trước và sau điều trị 4-6 tuần có ý nghĩa thống kê, với p < 0,001.
An Analysis of Growth Pattern and Volatility in Area, Production and Yield of Soybean in Major Producing States of India
Authors: Kalra Lekha , Srivastava S. K. 
Published: April 2023

Agriculture is one of the important sector of our Indian economy. Among agriculture various agricultural crops, oilseeds plays a major role by placing India at the 4th largest producer of oilseed in the world. Cultivation of oilseeds is done under 15-20 per cent of total area at global level (Kumar and Tiwari, 2020). Oilseeds group also considered to be one of the great sources of oil (soybean, groundnut, mustard, etc.) and protein (soybean). This study tried to analyse the trend in the area, production and productivity of soybean crop by fitting the exponential growth function. Further examination of instability in the crop was also done using Cuddy Della Valle index. The present study research period was taken from 1970-71 to 2017-18 which is further divided as follows: Pre Technology Mission on Oilseeds (Pre TMO) Period from 1970-71 to 1985-86, Technology Mission on Oilseeds Phase one Period from 1986-87 to 2001-02, Technology Mission on Oilseeds Phase two Period from 2002-03 to 2017-18, Overall Period of Technology Mission on Oilseeds from 1986-87 to 2017-18, Overall Period from 1970-71 to 1985-86. The Pre TMO period and Post TMO period criteria has been considered to estimate whether TMO had any impact on area, production , productivity, import and export of oilseeds. The study showed that during Pre TMO period, positive growth rate in the area of soybean was found positive in all the states except in Gujarat where area declined at the rate of 5.26 per cent per annum. Maximum rate of growth in the area was found in Rajasthan at the rate of 21.00 per cent per annum. During this period, production increased in all the states and country as a whole wherein, maximum rate of production registered in Rajasthan at the rate of 20.52 per cent per annum, production had shown negative growth in Gujarat at the rate of 0.08 per cent per annum. Productivity had shown increasing trend in all the states except in Rajasthan where negative growth is found at the rate of 0.40 per cent per annum. Maximum increase in the productivity was registered in Maharashtra at the rate of 7.78 per cent per annum. While the instability analysis revealed that fluctuations in the area of soybean was observed only in the state of Gujarat, whereas, Gujarat, Karnataka, Madhya Pradesh and Rajasthan production of soybean was comparatively less stable as compared to the other major states.
A Multi-disciplinary Investigation of Linearization Deviations in Different Regression Models
Authors: Yılmaz Kadir , Turanlı Münevver 
Published: April 2023

Aim: This study's objective is to examine linearization deviations in various regression models using a multidisciplinary approach.
Methods: Curve estimate models' accuracy for each type of data was tested using social, financial, and medical data sets.
Results: Although the power of a given model reduces with non-normal distributions, linearization in the social sciences is more efficient and has less variation from regression points in parametric equations. However, single-center distributions in the social sciences typically lead to nonparametric distributions. When compared to social sciences and health sciences, the effectiveness of linearization in financial sciences is higher. The original essence of financial techniques and models is frequently present, and they test their presumptions. Financial models and assumptions are more linear than those seen in real life since they correspond to artificial systems that individuals have developed, making them better suited for predetermined formulas. The rise in linearization issues in the field of finance, which has been increasingly common in recent years, is a symptom of this together with behavioral finance. Studies in the realm of health and well-known models were discovered to have the highest linearization deviations. Exponential or growth functions exhibit the highest linearization deviations in processes like growth, proliferation, and the spread of disease or pandemics. The data display considerable departures from normality and linearization, particularly in animal trials with very small statistical units or research conducted on a particular population.
Conclusion: Despite research on R2's explanatory capacity in regression, there aren't enough studies in various fields that concentrate on R2's departures from linearization. Additionally, no study was located in which the subject's mathematical foundation was examined and cross-compared across various data sets. As a result of this feature, the research represents a field first. The research's ability to pragmatically assess the distinctions between disciplines, made possible by its multi-disciplinary nature, is another unique aspect of the work.
Effectiveness of Hydroalcoholic Extract of Terminalia ivorensis on Feet Fungus Disease
Authors: Sitapha Ouattara , Marcelin Kouassi Konan Armand , Elisée Kporou Kouassi , Albert Lagbé Bahi Kalou Paul , Issa Bagré , Mathieu Kra Adou Koffi , David N’guessan Jean , Joseph Djaman Allico 
Published: April 2023

Despite the evolution of modern medicine, traditional medicine remains widespread in developing countries and its use continues to increase in industrialized countries.It is the same way that the effectiveness of the hydroalcoholic extract of Terminalia ivorensis was tested on the feet fungus disease of volunteers.
Objective: The present work is oriented in the preparation of an antimicrobial hydroalcoholic extract of Terminalia ivorensis, a medicinal plant in order to enhance it.
Materials and Methods: One hundred (100) grams of powder from trunk bark’s Terminalia ivorensis were extracted by homogenisation in a solvent mixture of 70% ethanol and 30% distilled water in a blender. After six grinding cycles, the homogenate obtained in each case was first wrung out in a clean white cloth square and then successively filtered twice on cotton wool and on Whatman 3 mm filter paper. The filtrate obtained was dried in a Venticell oven. The powder obtained constitutes the hydroalcoholic extract (or The 70% hydroethanolic extract). The 70% hydroethanolic extract of Terminalia ivorensis obtained was mixed with water to obtain a pasty liquid form before being tested on feet fungus disease using a cotton ball.
Results: The extract had activity on these different shapes of feet fungus disease with a marked improvement. The volunteers who finished their treatment have been cured of feet fungus disease.
Conclusion: The treatment results obtained revealed that the hydroalcoholic extract has good antimicrobial activity. The hydroalcoholic extract can be an undeniable source for the development of Improved Traditional Medicines (ITM) against feet fungus disease.
Trends in Mortality from Leading Causes in Brazil from 2011 to 2020: An Ecological Study
Authors: Andrade Natasha Cristina Oliveira , Freitas Karina Faine da Silva , Sousa Yasmin Martins de , Santos Suziane do Socorro dos , Correa Perla Katheleen Valente , Carvalho Maria de Lourdes Maia de Moraes de , Lima Danielle Etienne de Oliveira Bezerra , Soares Tamires de Nazaré , Vale Camila Carvalho do , Ramalho Jully Greyce Freitas de Paula , Sousa Bruna Rafaela da Silva , Kimura Mayara Annanda Oliveira Neves , Freitas Joyce dos Santos , Sardinha Daniele Melo 
Published: April 2023

Introduction: Deaths show the epidemiological scenario of the community and allow the planning of effective strategies for the prevention of deaths, mainly by immunopreventable and preventable causes, but for this the surveillance of death must have quality. Epidemiological studies should be carried out periodically to verify the epidemiological pattern of the causes.
Objective: To investigate the trends of mortality from leading causes in Brazil from 2011 to 2020.
Methodology: Ecological study, with secondary and public data, referring to the national surveillance of deaths. A descriptive and analytical analysis of the deaths per federation unit in Brazil was performed. We contrasted a graph with the six main causes and their trends, which was performed by the R2 equation. We calculated the mortality rate for 2011 and compared it with 2020. We also presented the mortality rates in a choroplectic map. The data were analyzed in Excel 2019, from aggregated data from DATASUS.
Results: The period of the study analyzed 12,899,133 million deaths in Brazil, and we highlight the six main causes.: IX Diseases of the circulatory system 3,498,722 (27.12%) upward trend 81%, II Neoplasms (tumors) 2,114,222 (16. 39%) increasing trend 96%, XX External causes of morbidity and mortality 1,512,786 (11.73%), X Respiratory system diseases 1,459,945 (11.52%) increasing trend 71%, IV Endocrine, nutritional and metabolic diseases 786,693 (6.10%) increasing trend 80%. We highlight the highest mortality rates in the federal units in the southeast, south, and northeast of Brazil. Rio de Janeiro had the highest mortality in 2011 611/100,000 inhabitants and also in 2020 785/100,000 inhabitants. Followed by Rio Grande do Sul in 2011 596/100,000 inhabitants and 2020 650/100,000 inhabitants.
Conclusion: We evidenced the tendency of increase in diseases of the circulatory system, respiratory, neoplasms and metabolic endocrine. Highlighting for neoplasms leading all causes, followed by diseases of the circulatory system, which was already known as the leading cause and annual increase. The public policies for the prevention of chronic diseases in Brazil must be strengthened, along with primary health care, to improve the scenario of deaths in Brazil.
The Effect of Intraoperative Fluid Therapy on Postoperative Renal Functions in Patients Undergoing Hyperthermic Intraperitoneal Chemotherapy and Cytoreductive Surgery: A Retrospective Observational Study
Authors: Kılıç Yeliz , Onay Meryem , Kayhan Gülay Erdoğan 
Published: April 2023

Aims: To investigate the effect of perioperative fluid management on postoperative renal functions in patients who underwent cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC).
Study Design: Retrospective observational study
Place and Duration of Study: Department of Anesthesiology and Reanimation, Faculty of Medicine, Osmangazi University, Eskişehir, Türkiye between January 2018 and January 2021.
Methodology: Data of 18 patients were analyzed. Hearth rate, mean arterial blood pressure, and brain oxygenation by near-infrared spectroscopy (NIRS) were evaluated in 3 CRS phases (at start, 1st hour and 2nd hour of CRS) and 4 HIPEC phases (at minute 15, 30, 45 and 60). Renal and hepatic functions, and full blood count were recorded preoperatively and at 2nd hour, 1st day, and 3rd day postoperatively. Acute kidney injury (AKI) was defined as a 1.5-fold increase in serum creatinine level according to the preoperative value.
Results: There were 14 (77.8%) women and 4 (22.2%) men, with a mean age of 53.3 years old. During both CRS and HIPEC phases, no patient's cerebral NIRS values dropped more than %20 compared with the baseline value. All of the patients received <15 ml/kg/h of intravenous fluid throughout the surgery (mean fluid volume was 12 ml/kg/h). AKI was developed in two patients.
Conclusion: The cornerstone of our fluid management in these patients was to adjust the amount of fluid under the guidance of urinary output and other hemodynamic indicators. In addition, excessive fluid administration was prevented with fluid infusion not exceeding 15 ml/kg/h. Although there is no evidence on optimal intraoperative fluid administration due to the limited number of studies, we hope that our study will contribute to the futher large scale, prospective, and randomized controlled trials.