bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perioperative Iron Deficiency in Patients Scheduled for Major Elective Surgeries: A French Prospective Multicenter Cross-Sectional Study
Authors: Capdevila Xavier , Lasocki Sigismond , Duchalais Alexis , Rigal Jean-Christophe , Mertl Patrice , Ghewy Pierre , Farizon Frédéric , Lanz Thomas , Buckert Axel , Belarbia Samia , Trochu Jean-Noël , Cacoub Patrice 
Published: March 2023

BACKGROUND:
The management of perioperative iron deficiency is a component of the concept of patient blood management. The objective of this study was to update French data on the prevalence of iron deficiency in patients scheduled for major surgery.

METHODS:
The CARENFER PBM study was a prospective cross-sectional study in 46 centers specialized in orthopedic, cardiac, urologic/abdominal, or gynecological surgery. The primary end point was the prevalence of iron deficiency at the time of surgery (D-1/D0) defined as serum ferritin <100 µg/L and/or transferrin saturation (TSAT) <20%.

RESULTS:
A total of 1494 patients (mean age, 65.7 years; women, 49.3%) were included from July 20, 2021 to January 3, 2022. The prevalence of iron deficiency in the 1494 patients at D-1/D0 was 47.0% (95% confidence interval [CI], 44.5–49.5). At 30 days after surgery, the prevalence of iron deficiency was 45.0% (95% CI, 42.0–48.0) in the 1085 patients with available data. The percentage of patients with anemia and/or iron deficiency increased from 53.6% at D-1/D0 to 71.3% at D30 (P < .0001), mainly due to the increase of patients with both anemia and iron deficiency (from 12.2% at D-1/D0 to 32.4% at D30; P < .0001). However, a treatment of anemia and/or iron deficiency was administered preoperatively to only 7.7% of patients and postoperatively to 21.7% (intravenous iron, 14.2%).

CONCLUSIONS:
Iron deficiency was present in half of patients scheduled for major surgery. However, few treatments to correct iron deficiency were implemented preoperatively or postoperatively. There is an urgent need for action to improve these outcomes, including better patient blood management.
Americium(III)/Curium(III) Complete Separation and Sensitive Fluorescence Detection by Capillary and Gel Electrophoresis Using Emissive Hexadentate/Octadentate Polyaminocarboxylate Ligands
Authors: Saito Shingo , Haraga Tomoko , Marumo Kazuki , Sato Yoshiyuki , Nakano Yuta , Tasaki-Handa Yuiko , Shibukawa Masami 
Published: March 2023

Abstract
Highly efficient and effective separation between americium (Am3+) and curium ion (Cm3+) was achieved by two simple electrophoresis-based techniques. Am3+ and Cm3+ ions were complexed with fluorophore-modified acyclic hexadentate and octadentate polyaminocarboxylates and then were electrophoretically separated and fluorescently detected in free solution with ternary complexation or in gel medium.
Physical Activity Trajectories in Early Childhood: Investigating Personal, Environmental, and Participation Factors
Authors: MCPHEE PATRICK G. , DI CRISTOFARO NATASCJA A. , CALDWELL HILARY A. T. , PROUDFOOT NICOLE A. , KING-DOWLING SARA , MACDONALD MAUREEN J. , CAIRNEY JOHN , BRAY STEVEN R. , TIMMONS BRIAN W. 
Published: March 2023

ABSTRACT

Introduction/Purpose
To determine personal, environmental, and participation factors that predict children’s physical activity (PA) trajectories from preschool through to school years.

Methods
Two hundred seventy-nine children (4.5 ± 0.9 yr, 52% boys) were included in this study. Physical activity was collected via accelerometry at six different timepoints over 6.3 ± 0.6 yr. Time-stable variables were collected at baseline and included child’s sex and ethnicity. Time-dependent variables were collected at six timepoints (age, years) and included household income (CAD), parental total PA, parental influence on PA, and parent-reported child’s quality of life, child’s sleep, and child’s amount of weekend outdoor PA. Group-based trajectory modeling was applied to identify trajectories of moderate-to-vigorous PA (MVPA) and total PA (TPA). Multivariable regression analysis identified personal, environmental, and participation factors associated with trajectory membership.

Results
Three trajectories were identified for each of MVPA and TPA. Group 3 in MVPA and TPA expressed the most PA over time, with increased activity from timepoints 1 to 3, and then declining from timepoints 4 to 6. For the group 3 MVPA trajectory, male sex (β estimate, 3.437; P = 0.001) and quality of life (β estimate, 0.513; P < 0.001) were the only significant correlates for group membership. For the group 3 TPA trajectory, male sex (β estimate, 1.970; P = 0.035), greater household income (β estimate, 94.615; P < 0.001), and greater parental total PA (β estimate, 0.574; P = 0.023) increased the probability of belonging to this trajectory group.

Conclusions
These findings suggest a need for interventions and public health campaigns to increase opportunities for PA engagement in girls starting in the early years. Policies and programs to address financial inequities, positive parental modeling, and improving quality of life are also warranted.
The impact of spinal fusion of adolescent idiopathic scoliosis in Salah (Islamic Prayer) movement: a case-control study
Authors: Irianto Komang Agung , Firas Naufal Ranadi , Binti Carlos Gracia Supriantono , Tinduh Damayanti , Sakti Yudha Mathan , De Vega Brigita 
Published: March 2023

Background: Corrective spine surgery is widely accepted for treating severe adolescent idiopathic scoliosis (AIS). Postoperative spinal range of motion (ROM) could be affected after such surgery. In certain populations, such as Muslims, this ROM change can impact daily life, as it may affect the five-times-a-day prayer (Salah). This study aims to assess the influence of spinal fusion (SF) in Adolescent Idiopathic Scoliosis (AIS) during the daily Islamic prayer (Salah). Methods: SF-AIS patients were videoed while performing Salah prayer. The kinematic documentation was assessed and compared to Salah movements of a control group of age-matched Muslim AIS patients, who had not had surgery. The prayer quality changes were subjectively classified into improved, no change/remained, and worsened, according to the Global Perceived Effect (GPE). Functional outcome and pain were assessed by the Scoliosis Research Society Questionnaire Version 30 (SRS-30). Results: Thirty-nine women and five men (mean age±SD: 14.8±2.3 years) met the inclusion criteria, and unoperated AIS patients were used as control (twenty-two women, mean age±SD: 15.32±1.43 years). The prostrations ROM of the SF-AIS group differed significantly from the control group (p<0.05). The GPE of the prayer movement showed improvement in 36.4%, no change in 59.1%, and worsening in 4.5% of the SF-AIS patients. The worsened group had a significantly lower bowing ROM and higher prostrations ROM compared to all groups of prayer quality changes (p<0.05). SRS-30 scores showed good outcomes (function 4.0±0.2, pain 4.2±0.5), along with the overall bowing ROM and prostrations ROM (84.2±12.0o and 53.4±9.6o, respectively). Moreover, a significant moderate positive correlation between the bowing ROM and pain (r=0.417, p=0.007) was also found. Conclusion: Spinal fusion positively affects AIS Islamic patients in maintaining their daily Salah movement, ROM and prayer quality. Prayer quality assessment should be given extra attention as an adjuvant of the SRS-30 questionnaire to evaluate Muslim patients.
PIMS - symptoms and short/long-term gastrointestinal and cardiovascular system complications
Authors: Grudzińska Aleksandra , Dudzińska Paulina , Milanowska Małgorzata , Jarosz Dominika , Tsitko Hanna 
Published: March 2023

PIMS (paediatric inflammatory multisystem syndrome associated with COVID-19 or Multisystem Inflammatory Syndrome in Children (MIS-C)) is a new disease classification, occurring in children and young adults associated with the SARS-CoV-2 infection. Although children suffer from COVID-19 infection asymptomatically or mildly, long-term complications of the disease may be more severe for them than for adults. Despite the fact that PIMS is a relatively new disease, we already know that it should not be underestimated. In spite of the clinical picture of these complications may resemble Kawasaki Disease (KD), we may notice some differences in laboratory tests (such as reduced number of lymphocytes, decreased platelet count or elevated ferritin levels). Although usually the first symptom of PIMS is high fever, it is followed by symptoms related to the digestive system, present in about 80% of cases. The insidious and severe gastrointestinal symptoms of PIMS can mimic abdominal surgical emergencies, including acute appendicitis, gastrointestinal infections or inflammatory bowel disease. Cardiovascular symptoms occur in approximately 60% of patients with PIMS. Immunomodulatory therapy plays an essential role in the treatment of PIMS. The exact causes of PIMS are recently unknown, however, it is explained as genetic hyperactivation of immunity. In this minireview we summarize the most recent data about this condition, mainly we are focusing on gastrointestinal and cardiovascular symptoms, short/long-term complications and treatment.
Diagnosis and management of lip filler complications – a case study with literature review
Authors: Wojtala Laura , Kapłon Kamil , Pawłocik Weronika , Szymańska Julia , Pawlak Weronika , Możdżyńska Agnieszka , Musiał Lena , Rymarz Anna , Kamińska Izabela , Grabowska Ewa 
Published: March 2023

Introduction
Aesthetic medicine treatments are becoming more popular in the 21st century due to the changing beauty standards and the treatments’ ability to help slow down the aging process. One of the most asked for treatments is a lip filler using hyaluronic acid. The popularity and frequency of the said treatment are directly connected to the rising number of complications in this area. The right diagnosis of lip filler complications allows to implement correct management and therefore therapeutic success for the patient.
The aim
The aim of the work was to analyze and discuss patient’s complications and implemented medical management after lip filler treatment using hyaluronic acid.
Case report
An individual case study that included clinical examination, medical and photographic documentation analysis.
Results
The patient was diagnosed with one of the most common complications after lip filler which is swelling. The swelling was a result of an allergic reaction and was classified as severe. Medical management using corticosteroid and antihistamines was implemented with a good therapeutic outcome.
Conclusions
Implemented management using corticosteroids and antihistamines for severe swelling after lip filler is effective. Due to the rising number of treatments using soft tissue fillers, it is expected that more patients will present with complications after aesthetic medicine procedures.
Superstar Exclusivity in Two-Sided Markets
Authors: Carroni Elias , Madio Leonardo , Shekhar Shiva 
Published: March 2023

In most platform environments, the exclusive provision of premium content from leading creators (superstars) is used as a strategy to boost user participation and secure a competitive edge vis-à-vis rivals. In this article, we study the impact of superstar exclusive content provision on platform competition and complementors’ homing decisions. Two competing platforms facilitate interactions between consumers and suppliers, of which the latter are identified by the superstar and a fringe of complementors (e.g., independent developers, amateurs). When platform competition is intense, more consumers become affiliated with the platform favored by superstar exclusivity. This mechanism is self-reinforcing as it generates an entry cascade of complementors, and some complementors single home on the favored platform. We find that cross-group externalities are key in shaping market outcomes. First, exclusivity benefits complementors and might make consumers better off when cross-group externalities are large enough. Second, contrary to conventional wisdom, vertical integration (platform-superstar) may make exclusivity less likely than vertical separation under reasonable conditions. Finally, we discuss implications for the strategies of platform owners, managers of superstars and complementors, and antitrust enforcers. This paper was accepted by Joshua Gans, business strategy. Funding: L. Madio gratefully acknowledges financial support from the Economic and Social Research Council [Grant ES/J500215/1], the UCLouvain “Move-in” Fellowship Programme, the European Research Council under the European Union’s Horizon 2020 Research and Innovation Programme [Grant 670494], and the Unicredit & Universities Foscolo Europe Fellowship. Supplemental Material: The online appendix is available at https://doi.org/10.1287/mnsc.2023.4720 .
Öz Şefkat Yaklaşımının Tüketici Davranışı Üzerindeki Etkisinin İncelenmesi
Authors: TOMRİS KÜÇÜN Nihan 
Published: March 2023

Pazarlama, geçirdiği tarihsel dönüşüm neticesinde günümüzde hem markalar hem de tüketici için değer yaratan bir yaklaşıma sahip olacak şekilde gelişmiştir. Bu bağlamda tüketicileri anlamak ve etkin bir iletişim kurabilmek, uzun dönemli bir sürdürülebilirlik sağlamak bakımından anahtar niteliğinde görülmektedir. Belirtilen önem neticesinde tüketicilerin bireysel düzeyde anlaşılabilmesi ve desteklenebilmesi, pazarlama iletişiminin sağlıklı bir düzeyde yürütülebilecek şekilde yapılandırılması için oldukça belirleyicidir.
Bireysel psikolojinin önemli konularından biri olan başa çıkma stratejileri, bireylerin belli bir zorlukla karşı karşıya kalmaları durumunda başvurdukları yollar olarak tanımlanmaktadır. Benlik ve benliğe yönelik bireysel değerlendirmeler odağında tanımlanan bu stratejilere 2000’li yılların başında “öz şevkat” kavramı eklenmiştir. Öz şefkat; ortak insanlık, farkındalık ve öz nezaket olmak üzere üç farklı boyuta sahiptir. Bireylerin deneyimlediği bir zorluk karşısında uzun dönemli, öz- yargılamadan uzak ve yapıcı bir yaklaşım sergilemesi olarak özetlenebilecek olan öz şevkat, psikoloji alanında uzun süredir çalışılmaktadır. Bunun yanı sıra yakın dönemde iletişim araştırmalarında ve yönetim organizasyon alanında da kavrama yer verildiği görülmektedir. Bununla beraber pazarlama alanında yürütülen araştırmalar oldukça kısıtlıdır. Oysaki insan davranışı, bireylerin psikolojik durumlarından ayrı değerlendirilmeyecek kadar bütünsel bir çıktıdır ve tüketici davranışlarının anlaşılması için kapsamın geliştirilmesine yönelik yaklaşımlar büyük önem taşımaktadır.
Belirtilen sebeplerle bu araştırmada, pazarlama perspektifi ile geliştirilen öz şefkat odaklı çalışmalar incelenmiş, alana ve uygulamacılara sağlayabileceği potansiyel katkı bakımından değerlendirilmiştir. Literatürün henüz gelişme aşamasında olması sebebiyle bu araştırmaların sonrakiler için önemli bir zemin oluşturacağı öngörülmektedir.
A survey on the usage of decellularized tissues in orthopaedic clinical trials
Authors: Itoh Masafumi , Itou Junya , Imai Shinya , Okazaki Ken , Iwasaki Kiyotaka 
Published: March 2023

AimsOrthopaedic surgery requires grafts with sufficient mechanical strength. For this purpose, decellularized tissue is an available option that lacks the complications of autologous tissue. However, it is not widely used in orthopaedic surgeries. This study investigated clinical trials of the use of decellularized tissue grafts in orthopaedic surgery.MethodsUsing the ClinicalTrials.gov (CTG) and the International Clinical Trials Registry Platform (ICTRP) databases, we comprehensively surveyed clinical trials of decellularized tissue use in orthopaedic surgeries registered before 1 September 2022. We evaluated the clinical results, tissue processing methods, and commercial availability of the identified products using academic literature databases and manufacturers’ websites.ResultsWe initially identified 4,402 clinical trials, 27 of which were eligible for inclusion and analysis, including nine shoulder surgery trials, eight knee surgery trials, two ankle surgery trials, two hand surgery trials, and six peripheral nerve graft trials. Nine of the trials were completed. We identified only one product that will be commercially available for use in knee surgery with significant mechanical load resistance. Peracetic acid and gamma irradiation were frequently used for sterilization.ConclusionDespite the demand for decellularized tissue, few decellularized tissue products are currently commercially available, particularly for the knee joint. To be viable in orthopaedic surgery, decellularized tissue must exhibit biocompatibility and mechanical strength, and these requirements are challenging for the clinical application of decellularized tissue. However, the variety of available decellularized products has recently increased. Therefore, decellularized grafts may become a promising option in orthopaedic surgery.Cite this article:Bone Joint Res 2023;12(3):179–188.
Demonstration of continuous multiple access with homodyne and image-rejection heterodyne coherent receivers using directly modulated laser transmitters
Authors: Masanas Miquel , Tabares Jeison , Cano Ivan , Prat Josep 
Published: March 2023

This work presents a comprehensive set of experiments for the multipoint-to-point coherent passive optical network (PON), where the wavelength locking between the optical network unit (ONU) and optical line termination lasers is critical, especially if operating in burst mode. Here, we test the performance of continuous multiple access in a splitter-based PON with both an ultra-dense wavelength division multiplexing and RF-subcarrier multiplexing configuration, with simple distributed feedback (DFB) lasers along non-return to zero and pulse amplitude modulation of four levels. Most interestingly, we test a spectrally efficient heterodyne receiver with image-frequency rejection and polarization independence based on the 3×3 optical front-end. Two users at the same intermediate frequency are detected simultaneously avoiding image frequency interference while minimizing complexity, with transmissions of 2.5 Gb/s. We provide comparison with an asynchronous homodyne receiver. The achieved results demonstrate the feasibility of continuous multiple access using thermally controlled ONUs with conventional DFBs as an enhanced alternative to commercial time division multiplexing access.
Mirikizumab regulates genes involved in ulcerative colitis disease activity and anti-TNF resistance: results from a phase 2 study
Authors: Steere Boyd , Schmitz Jochen , Powell Nick , Higgs Richard , Gottlieb Klaus , Liu Yushi , Jia Bochao , Tuttle Jay L , Sandborn William J , Sands Bruce E , D’Haens Geert , Reinisch Walter , Krishnan Venkatesh 
Published: March 2023

ABSTRACT

Introduction:
Mirikizumab, a monoclonal antibody targeting the p19 subunit of interleukin (IL)23, demonstrated efficacy and was well-tolerated in a phase 2 randomized clinical trial in patients with moderate-to-severe ulcerative colitis (UC) (NCT02589665). We explored gene expression changes in colonic tissue from study patients and their association with clinical outcomes.

Methods:
Patients were randomized to receive intravenous placebo or three mirikizumab induction doses. Patient biopsies were collected at baseline and Week 12, and differential gene expression was measured using a microarray platform and compared in all treatment groups to determine differential expression values between baseline and Week 12.

Results:
The greatest improvement in clinical outcomes and placebo-adjusted change from baseline in transcripts at Week 12 were observed in the 200 mg mirikizumab group. Transcripts significantly modified by mirikizumab correlate with key UC disease activity indices (modified Mayo score, Geboes Score, Robarts Histopathology Index) and include MMP1, MMP3, S100A8, and IL1B. Changes in transcripts associated with increased disease activity were decreased after 12 weeks of mirikizumab treatment. Mirikizumab treatment affected transcripts associated with resistance to current therapies, including IL-1B, OSMR, FCGR3A and FCGR3B, and CXCL6, suggesting that anti-IL23p19 therapy modulates biological pathways involved in resistance to anti-TNF and JAK inhibitors.

Discussion:
This is the first large-scale gene expression study of inflamed mucosa from patients with UC treated with anti-IL23p19 therapy. These results provide molecular evidence for mucosal healing from an extensive survey of changes in transcripts that improve our understanding of the molecular effects of IL-23p19 inhibition in UC.
Influencia del tipo de fibras y del tratamiento superficial de las fibras en las propiedades físicas y mecánicas de compuestos reforzados con fibras vegetales
Authors: Sánchez-Cruz Martha Lissette , Capote Rodriguez Gil , Patiño-Quiazua Juan Pablo 
Published: March 2023

Contexto: La preocupación por la mitigación del impacto ambiental generado por el uso de fibras sintéticas como refuerzo de los materiales compuestos tradicionales ha promovido el diseño y caracterización de compuestos elaborados a partir de la combinación de materiales de origen vegetal. No obstante, a pesar de sus múltiples ventajas, para su empleo eficiente como materiales de construcción es necesario profundizar en la determinación del efecto de los parámetros de diseño en su desempeño mecánico.

Método: El presente estudio tiene como objetivo determinar el efecto de los parámetros de diseño (tipo de fibras y tratamiento superficial en las propiedades físicas y mecánicas de paneles elaborados con materiales (fibras y resina) de origen vegetal. Para la elaboración del compuesto fueron utilizadas dos tipos de fibras: fibras de Arundo Dónax y fibras de Guadua Angustifolia Kunth. Para la elaboración de los paneles las fibras fueron distribuidas de manera aleatoria en una resina vegetal, obtenida a partir del procesamiento del aceite de ricino. Para evaluar el efecto del tratamiento en las propiedades del compuesto tres condiciones fueron consideradas: fibras sin tratamiento, fibras tratadas con solución de hidróxido de sodio y fibras tratadas con plasma. La densidad en estado anhidro, la capacidad de absorción efectiva, la absorción superficial, el porcentaje de hinchamiento, el módulo de rotura y el módulo de elasticidad aparente fueron determinados experimentalmente. A partir de los resultados experimentales se realizó un análisis de la superficie de respuesta mediante la implementación de un diseño central compuesto, utilizando un programa comercial.

Resultados: A partir de los resultados experimentales se realizó un análisis de la superficie de respuesta. Para cada una de las propiedades estudiadas se obtuvieron los diagramas de Pareto y los gráficos de contorno. A partir de los resultados estadísticos fue posible establecer ecuaciones que permiten predecir las propiedades del compuesto en función del tipo de fibra y el tratamiento aplicado en su superficie.

Conclusiones: A partir de los resultados obtenidos fue posible verificar el efecto del tipo de fibras y de su modificación superficial en las propiedades físicas de compuestos elaborados con materiales de origen vegetal. Otros parámetros como orientación de las fibras, así como variables asociadas a las condiciones de procesamiento (presión y tiempo de compactación) pueden influir en las propiedades del material) y serán abordadas en trabajos futuros.