bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diagnostic value of protein S100b as predictor of traumatic intracranial haemorrhage in elderly adults with low-energy falls: results from a retrospective observational study
Authors: Wania Rebecca , Lampart Alina , Niedermeier Sandra , Stahl Robert , Trumm Christoph , Reidler Paul , Kammerlander Christian , Böcker Wolfgang , Klein Matthias , Pedersen Vera 
Published: July 2023

Abstract
Purpose
The objectives of this study were to analyse the clinical value of protein S100b (S100b) in association with clinical findings and anticoagulation therapy in predicting traumatic intracranial haemorrhage (tICH) and unfavourable outcomes in elderly individuals with low-energy falls (LEF).

Methods
We conducted a retrospective study in the emergency department (ED) of the LMU University Hospital, Munich by consecutively including all patients aged ≥ 65 years presenting to the ED following a LEF between September 2014 and December 2016 and receiving an emergency cranial computed tomography (cCT) examination. Primary endpoint was the prevalence of tICH. Multivariate logistic regression models and receiver operating characteristics were used to measure the association between clinical findings, anticoagulation therapy and S100b and tICH.

Results
We included 2687 patients, median age was 81 years (60.4% women). Prevalence of tICH was 6.7% (180/2687) and in-hospital mortality was 6.1% (11/180). Skull fractures were highly associated with tICH (odds ratio OR 46.3; 95% confidence interval CI 19.3–123.8, p < 0.001). Neither anticoagulation therapy nor S100b values were significantly associated with tICH (OR 1.14; 95% CI 0.71–1.86; OR 1.08; 95% CI 0.90–1.25, respectively). Sensitivity of S100b (cut-off: 0.1 ng/ml) was 91.6% (CI 95% 85.1–95.9), specificity was 17.8% (CI 95% 16–19.6), and the area under the curve value was 0.59 (95% CI 0.54 − 0.64) for predicting tICH.

Conclusion
In conclusion, under real ED conditions, neither clinical findings nor protein S100b concentrations or presence of anticoagulation therapy was sufficient to decide with certainty whether a cCT scan can be bypassed in elderly patients with LEF. Further prospective validation is required.
An unwelcome inheritance: childhood obesity after diabetes in pregnancy
Authors: Meek Claire L. 
Published: July 2023

AbstractDiabetes in pregnancy affects 20 million women per year and is associated with increased risk of obesity in offspring, leading to insulin resistance and cardiometabolic disease. Despite the substantial public health ramifications, relatively little is known about the pathophysiological mechanisms underlying obesity in these high-risk children, which creates a barrier to successful intervention. While maternal glucose itself is undeniably a major stimulus upon intrauterine growth, the degree of offspring hyperinsulinism and disturbed lipid metabolism in mothers and offspring are also likely to be implicated in the disease process. The aim of this review is to summarise current understanding of the pathophysiology of childhood obesity after intrauterine exposure to maternal hyperglycaemia and to highlight possible opportunities for intervention. I present here a new unified hypothesis for the pathophysiology of childhood obesity in infants born to mothers with diabetes, which involves self-perpetuating twin cycles of pancreatic beta cell hyperfunction and altered lipid metabolism, both acutely and chronically upregulated by intrauterine exposure to maternal hyperglycaemia.
Graphical Abstract
Persistent animal identification leveraging non-visual markers
Authors: Camilleri Michael P. J. , Zhang Li , Bains Rasneer S. , Zisserman Andrew , Williams Christopher K. I. 
Published: July 2023

AbstractOur objective is to locate and provide a unique identifier for each mouse in a cluttered home-cage environment through time, as a precursor to automated behaviour recognition for biological research. This is a very challenging problem due to (i) the lack of distinguishing visual features for each mouse, and (ii) the close confines of the scene with constant occlusion, making standard visual tracking approaches unusable. However, a coarse estimate of each mouse’s location is available from a unique RFID implant, so there is the potential to optimally combine information from (weak) tracking with coarse information on identity. To achieve our objective, we make the following key contributions: (a) the formulation of theobject identificationproblem as an assignment problem (solved using Integer Linear Programming), (b) a novel probabilistic model of the affinity between tracklets and RFID data, and (c) a curated dataset with per-frame BB and regularly spaced ground-truth annotations for evaluating the models. The latter is a crucial part of the model, as it provides a principled probabilistic treatment of object detections given coarse localisation. Our approach achieves 77% accuracy on this animal identification problem, and is able to reject spurious detections when the animals are hidden.
Optimizing the macrostructure of 3D-printed pipe surfaces to improve cleanability
Authors: Hanisch Tobias , Joppa Matthias , Eisenrauch Vincent , Jacob Sebastian , Mauermann Marc 
Published: July 2023

AbstractEfficient heat transfer is essential for the economically sustainable operation of heat exchangers. Therefore, the internal flow is influenced systematically in various ways, for example by introducing macrostructures on the pipe surface. Since these measures may negatively affect the cleanability of the heat exchanger, it is necessary to investigate not only the increase in heat transfer, but also their impact on cleaning processes. For this purpose, the cleaning of sour milk in dimple-structured pipes is investigated experimentally. Both macroscopic and microbial cleaning tests are conducted to assess the influence of the surface’s macrostructure on cleanability. Two geometry variations of dimple-structured pipes are investigated and compared to a straight pipe Although fouling is enhanced by the dimple structures, a higher macroscopic cleaning rate can be achieved with the optimized dimple. Moreover, the residual microbial contamination decreases significantly due to the introduction of dimples. All in all, the cleaning experiments confirm the positive influence of the dimple structures on cleanability.
Mercury in Ten Storm-Petrel Populations from the Antarctic to the Subtropics
Authors: Quillfeldt Petra , Bedolla-Guzmán Yuliana , Libertelli Marcela M. , Cherel Yves , Massaro Melanie , Bustamante Paco 
Published: July 2023

AbstractThe oceans become increasingly contaminated as a result of global industrial production and consumer behaviour, and this affects wildlife in areas far removed from sources of pollution. Migratory seabirds such as storm-petrels may forage in areas with different contaminant levels throughout the annual cycle and may show a carry-over of mercury from the winter quarters to the breeding sites. In this study, we compared mercury levels among seven species of storm-petrels breeding on the Antarctic South Shetlands and subantarctic Kerguelen Islands, in temperate waters of the Chatham Islands, New Zealand, and in temperate waters of the Pacific off Mexico. We tested for differences in the level of contamination associated with breeding and inter-breeding distribution and trophic position. We collected inert body feathers and metabolically active blood samples in ten colonies, reflecting long-term (feathers) and short-term (blood) exposures during different periods ranging from early non-breeding (moult) to late breeding. Feathers represent mercury accumulated over the annual cycle between two successive moults. Mercury concentrations in feathers ranged over more than an order of magnitude among species, being lowest in subantarctic Grey-backed Storm-petrels (0.5 μg g−1 dw) and highest in subtropical Leach’s Storm-petrels (7.6 μg g−1 dw, i.e. posing a moderate toxicological risk). Among Antarctic Storm-petrels, Black-bellied Storm-petrels had threefold higher values than Wilson’s Storm-petrels, and in both species, birds from the South Shetlands (Antarctica) had threefold higher values than birds from Kerguelen (subantarctic Indian Ocean). Blood represents mercury taken up over several weeks, and showed similar trends, being lowest in Grey-backed Storm-petrels from Kerguelen (0.5 μg g−1 dw) and highest in Leach’s Storm-petrels (3.6 μg g−1 dw). Among Antarctic storm-petrels, species differences in the blood samples were similar to those in feathers, but site differences were less consistent. Over the breeding season, mercury decreased in blood samples of Antarctic Wilson’s Storm-petrels, but did not change in Wilson’s Storm-petrels from Kerguelen or in Antarctic Black-bellied Storm-petrels. In summary, we found that mercury concentrations in storm-petrels varied due to the distribution of species and differences in prey choice. Depending on prey choices, Antarctic storm-petrels can have similar mercury concentrations as temperate species. The lowest contamination was observed in subantarctic species and populations. The study shows how seabirds, which accumulate dietary pollutants in their tissues in the breeding and non-breeding seasons, can be used to survey marine pollution. Storm-petrels with their wide distributions and relatively low trophic levels may be especially useful, but more detailed knowledge on their prey choice and distributions is needed.
Pregnancy glucagon-like peptide 1 predicts insulin but not glucose concentrations
Authors: Jones Danielle L. , Petry Clive J. , Burling Keith , Barker Peter , Turner Elizabeth H. , Kusinski Laura C. , Meek Claire L. 
Published: July 2023

Abstract
Aims
Incretin hormones glucagon-like peptide 1 (GLP-1) and gastric inhibitory peptide (GIP) cause increased insulin secretion in non-pregnant adults, but their role in pregnancy, where there are additional metabolically-active hormones from the placenta, is less clear. The aim of the present study was to assess if fasting and post-load incretin concentrations were predictive of pregnancy insulin and glucose concentrations.

Methods
Pregnant women (n = 394) with one or more risk factors for gestational diabetes were recruited at 28 weeks for a 75 g oral glucose tolerance test (OGTT). Glucose, insulin, GLP-1 and GIP were measured in the fasting state and 120 min after glucose ingestion.

Results
Fasting plasma GLP-1 concentrations were associated with plasma insulin (standardised β’ 0.393 (0.289–0.498), p = 1.3 × 10–12; n = 306), but not with glucose concentrations (p = 0.3). The association with insulin was still evident when adjusting for BMI (β’ 0.271 (0.180–0.362), p = 1.1 × 10–8; n = 297). Likewise, at 120 min the OGTT GLP-1 concentrations were associated with plasma insulin concentrations (β’ 0.216 (0.100–0.331), p  = 2.7 × 10–4; n = 306) even after adjusting for BMI (β’ 0.178 (0.061–0.294), p = 2.9 × 10–3; n = 296), but not with glucose (p  = 0.9). GIP concentrations were not associated with insulin or glucose concentrations at either time point (all p  > 0.2). In pregnancy plasma GLP-1, but not GIP, concentrations appear to be predictive of circulating insulin concentrations, independently of associations with BMIs.

Conclusions
These results suggest that the relationship between insulin and incretins is preserved in pregnancy, but that other factors, such as placental hormones or counter-regulatory hormones, may be more important determinants of glycaemia and gestational diabetes aetiology.
Temporal prediction of shallow landslides exploiting soil saturation degree derived by ERA5-Land products
Authors: Bordoni Massimiliano , Vivaldi Valerio , Ciabatta Luca , Brocca Luca , Meisina Claudia 
Published: July 2023

AbstractERA5-Land service has been released recently as an integral and operational component of Copernicus Climate Change Service. Within its set of climatological and atmospheric parameters, it provides soil moisture estimates at different soil depths, represeting an important tool for retrieving saturation degree for predicting natural hazards as shallow landslides. This paper represents an innovative attempt aiming to exploit the use of saturation degree derived from ERA5-Land soil moisture products in a data-driven model to predict the daily probability of occurence of shallow landslides. The study was carried out by investigating a multi-temporal inventory of shallow landslides occurred in Oltrepò Pavese (northern Italy). The achieved results follow: (i) ERA5-Land-derived saturation degree reconstructs well field trends measured in the study area until 1 m from ground; (ii) in agreement with the typical sliding surfaces depth, saturation degree values obtained since ERA5-Land 28–100 cm layer represent a significant predictor for the estimation of temporal probability of occurrence of shallow landslides, able especially to reduce overestimation of triggering events; (iii) saturation degree estimated by ERA5-Land 28–100 cm layer allows to detect soil hydrological conditions leading to triggering in the study area, represented by saturation degree in this layer close to complete saturation. Even if other works of research are required in different geological and geomorphological settings, this study demonstrates that ERA5-Land-derived saturation degree could be implemented to identify triggering conditions and to develop prediction methods of shallow landslides, thanks also to its free availability and constantly updating with a delay of 5 days.
Urinary aberrations in systemic lupus erythematosus not always indicative of lupus nephritis: a cross-sectional cohort study
Authors: Karlsson Linnea , Zickert Agneta , Svenungsson Elisabet , Schmidt-Mende Jan , Faustini Francesca , Gunnarsson Iva 
Published: July 2023

Abstract
Introduction
Kidney biopsy is the reference tool for diagnosing and guiding treatment strategies in inflammatory renal diseases, such as lupus nephritis (LN).
We investigated the histopathological findings in first-time kidney biopsies from a large cohort of SLE patients. We focused on the occurrence and type of histopathological findings other than LN, and fulfillment of renal criteria in established SLE classification systems were analyzed.

Methods
We retrospectively included SLE patients (n = 139) who underwent a first kidney biopsy between 1995 and 2021, upon clinical suspicion of renal involvement. Based on histology, two groups were defined, LN and non-LN, for which clinical and laboratory features were compared.

Results
Findings consistent with LN according to ISN/RPS classification system were present in 123/139 patients (88.5%) and findings not consistent with LN were present in 16 /139 (11.5%).
Non-LN patients were older at SLE diagnosis compared to LN patients (M, years 38.0 vs. 30.1, p=0.013) and had longer disease duration (M, years 11.9 vs 0.5) (p=0.027).
Among non-LN patients 85.7% met the SLICC criteria item for renal SLE, seen in 94.7% in the LN group (ns). For the ACR/EULAR criteria, 66.7% of the non-LN group fulfilled the criteria compared to 74.8% in LN patients (ns). Proteinuria below the criteria cut-off level (< 0.5 g/24 h) was seen in 20% of patients with class III/IV LN.

Conclusion
Our data confirm the importance of kidney biopsy for ruling out the presence of renal pathology other than LN. Patients with low-grade proteinuria may exhibit severe types of LN, which reinforces the need for early biopsies to detect LN.

Key Points• Our findings show that histopathology changes other than lupus nephritis may occur in a significant number of patients with clinical and laboratory signs of novel kidney involvement.• Low-grade proteinuria does not exclude findings of active lupus nephritis that require the start of immunosuppressive therapy.• The study stresses the importance of performing kidney biopsies also in the presence of low-grade proteinuria or when signs of kidney function abnormalities occur.• This is crucial as early detection and prompt initiation of therapy may improve outcomes in lupus nephritis.
Adaptive mesh refinement in locally conservative level set methods for multiphase fluid displacements in porous media
Authors: Singh Deepak , Friis Helmer André , Jettestuen Espen , Helland Johan Olav 
Published: July 2023

AbstractMultiphase flow in porous media often occurs with the formation and coalescence of fluid ganglia. Accurate predictions of such mechanisms in complex pore geometries require simulation models with local mass conservation and with the option to improve resolution in areas of interest. In this work, we incorporate patch-based, structured adaptive mesh refinement capabilities into a method for local volume conservation that describes the behaviour of disconnected fluid ganglia during level set simulations of capillary-controlled displacement in porous media. We validate the model against analytical solutions for three-phase fluid configurations in idealized pores containing gas, oil, and water, by modelling the intermediate-wet oil layers as separate domains with their volumes preserved. Both the pressures and volumes of disconnected ganglia converge to analytical values with increased refinement levels of the adaptive mesh. Favourable results from strong and weak scaling tests emphasize that the number of patches per processor and the total number of patches are important parameters for efficient parallel simulations with adaptive mesh refinement. Simulations of two-phase imbibition and three-phase gas invasion on segmented 3D images of water-wet sandstone show that adaptive mesh refinement has the highest impact on three-phase displacements, especially concerning the behaviour of the conserved, intermediate-wet phase.
Therapeutic efficacy of coriander (Coriandrum sativum) enriched diets in Oreochromis niloticus: effect on hepatic-renal functions, the antioxidant-immune response and resistance to Aeromonas veronii
Authors: Said Ahmed Abdou , Reda Rasha M. , Metwally Mohamed M. M. , Abd El-Hady Heba M. 
Published: July 2023

AbstractIn this study, the effects of Coriandrum sativum to control Aeromonas veronii infection in Oreochromis niloticus were determined. Coriandrum sativum extract (CE) was tested in vitro against A. veronii by the disc diffusion assay. In in vivo, 150 O. niloticus (from El-Abbassa, Sharkia, Egypt, weighing 34.95 ± 1.98 g) was distributed in five groups (with three replications) in glass aquariums (80 × 40 × 30 cm). The first group (control) was intraperitoneally injected with 0.2 ml of sterilized tryptic soya broth. Groups 2–5 were intraperitoneally challenged with 0.2 ml of A. veronii (4.3 × 106). The five groups were administered a basal diet until clinical signs appeared, and then therapeutic feeding (15 days) was followed: the first (CONT) and second (AV) groups were administered a normal basal diet. The third (AV+CP) and fourth (AV+CE) groups were administered diets supplemented with C. sativum powder and extract, respectively, each at 30 mg/kg. The fifth group (AV+OT) was administered a diet supplemented with oxytetracycline at 500 mg/kg diet. The results of the in vitro experiment revealed that CE has a zone of inhibition of 43 mm against A. veronii. The in vivo results showed that fish administered a therapeutic diet supplemented with CE showed a significant improvement in hematological, biochemical, and immunological parameters, as well as antioxidant capacity (P < 0.05) and the pathological findings of the liver and kidney tissues. The current findings supported that the administration of a CE-enriched diet (30 mg/kg) is an eco-friendly strategy for controlling A. veronii in O. niloticus.
Do informal networks become formalised over time? Analysing school networks and multi-academy trust membership in England using ego-centric analysis
Authors: Greany Toby , Cowhitt Tom , Downey Chris 
Published: July 2023

AbstractRecent decades have seen a global shift in educational policy and practice towards various forms of ‘joining-up’, through partnerships and networks. These networks have differing aims but are broadly geared towards increasing quality and/or innovation in educational provision, although many prove messy and problematic. Policy makers in England have encouraged schools to collaborate, although parallel market pressures can also drive competition, leading to an argument that schools must engage in ‘coopetition’. More recently, policy has encouraged schools to form or join a multi-academy trust (MAT) and the government’s stated aim is that all 21,000 schools in England will be part of a MAT by 2030. A MAT is a formal legal entity with a board and Chief Executive which oversees multiple schools. The headline question we address is whether pre-existing partnerships between schools predict eventual membership of multi-academy trusts? We do this through an analysis of ego network and case study interview data collected from 20 schools across two local areas. We track these networks over a seven-year period, identifying which schools join which MATs. We find that schools do not form or join MATs with other local schools they have collaborated with in the past. We assess this somewhat counter-intuitive finding through the lens of socio-spatial theory, presenting a framework for assessing the interactions between place, scale and networks and considering the implications for policy, practice and research.
Fundamental Scaling of Adiabatic Compression of Field Reversed Configuration Thermonuclear Fusion Plasmas
Authors: Kirtley D. , Milroy R. 
Published: July 2023

AbstractField Reversed Configuration (FRC) plasmas are plasma devices that have demonstrated that through magnetic compression they can be heated to thermonuclear fusion conditions in the parameter space of an energy-producing generator Kirtley et al. (IEEE Symposium on Fusion Engineering, 2021). Of particular interest, FRCs are high-beta, in that the plasma particle kinetic energy is in balance with an externally applied magnetic field at all stages of operation. The following work will show that a cylindrical approximation for the energy and particle distribution within an FRC can, within 11%, match the fusion performance results of both full Magnetohydrodynamic (MHD) simulations as well as all robust, modern theoretical spatial and energy distribution models. Further, by using the simplified cylindrical model, detailed fusion reaction, radiation, and energy transport equations are now numerically-tractable and can be modelled over a wide parameter space. In the second section of this work, a detailed numerical model will be presented with the key theoretical performance of the compression of high-beta fusion plasmas in both deuterium–tritium (D–T) and deuterium–helium-3 (D–He-3) fuels. As will be shown, a high-beta D–He-3 plasma outperforms a low-beta D–T fuel and can theoretically yield a net-positive fusion generator.