bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diagnosis and Clinical Significance of «Hidden» Spectral Disorders of Blood Oxygenation Among Smokers with Exacerbation of Bronchial Asthma
Authors: Gnoevykh V. V. , Shorokhova Yu. A. , Smirnova A. Yu. , Efremova E. V. 
Published: January 2023

The purpose of the study — to identify and evaluate the clinical significance of “hidden” disorders of blood oxygenation in smokers with exacerbation of bronchial asthma.Materials and methods: spirometry, pulse oximetry, CO-metry of exhaled air. To diagnose “hidden” disorders of blood oxygenation, including “hidden” violations of the spectral characteristics of the level of hemoglobin oxygen saturation, 19 male smokers (middle age 54,6±2,05 years) with exacerbation of mixed (68 %) or allergic (32 %) bronchial asthma were examined.The results: the accuracy of the clinical assessment of blood oxygenation in smokers increased significantly after the correction of the SpO2 level to the level of carboxyhemoglobin with the help of a computer program developed by us, which made it possible to diagnose a clinically significant lifethreatening exacerbation of this disease in smoking patients with bronchial asthma, since “hidden” respiratory insufficiency was detected in a timely manner.
Substitusi Jagung (Zea Mays L.) Dalam Pembuatan Bakpao Sebagai Pangan Fungsional
Authors: Chita Cahya , Ani Nuraeni  , Yulia Kurnia Ningsih  , Endah Ayu Andari  , Annisa Rizkiriani  , Vieta Annisa Nurhidayati  , Della Modesty  
Published: January 2023

Abstract
Corn bakpao is a snack that is loved by the public because of its soft texture. Corn contains nutrient content like carbohydrates, fiber, vitamin, potassium, linoleic acid, beta carotene, mineral, and protein. Corn silk contains bioactive compounds which can act as antioxidants for the body and to decrease cholesterol levels. The purpose of this research is to get innovative products in the form of bakpao which are substituted with corn as a functional food. This research uses 2 formulas with different quantities substitutes of flour and corn for getting the right formula and being the most liked by consumers. The best result based on the organoleptic test was on formula 1 with 200 gram flour and 50 gram corn.
Keywords: Bakpao, Corn, Functional Food, Consumer Acceptance
Integrating Racism as a Sentinel Indicator in Public Health Surveillance and Monitoring Systems
Authors: White Kellee , Beatty Moody Danielle L. , Lawrence Jourdyn A. 
Published: January 2023

Objectives. To evaluate public health surveillance and monitoring systems’ (PHSMS) efforts to collect, monitor, track, and analyze racism. Methods. We employed an environmental scan approach. We defined key questions and data to be collected, conducted a literature review, and synthesized the results by using a qualitative description approach. Results. We identified 125 PHSMS; only 3—the Behavioral Risk Factor Surveillance System, Pregnancy Risk Assessment and Monitoring System, and California Health Interview Survey—collected and reported data on individual-level racism. Structural racism was not collected in PHSMS; however, we observed evidence for linkages to census and administrative data sets or social media sources to assess structural racism. Conclusions. There is a paucity of PHSMS that measure individual-level racism, and few systems are linked to structural racism measures. Public Health Implications. Adopting a standard practice of racism surveillance can advance equity-centered public health praxis, inform policy, and foster greater accountability among public health practitioners, researchers, and decision-makers. Failure to explicitly address racism and the insufficient capacity to support a robust health equity data infrastructure severely impedes efforts to address and dismantle systemic racism. (Am J Public Health. 2023;113(S1):S80–S84. https://doi.org/10.2105/AJPH.2022.307160 )
Experimental observation of permanent magnet rotation
Authors: Tong Weiming , Chen Bihe 
Published: January 2023

Abstract
Why does the Earth rotate? At present, it is impossible to use an experimental device to show which forces cause planets (such as Earth) to rotate in the solar system. Therefore, we developed a device to observe the rotation of a permanent magnet in a magnetic field to achieve an understanding of rotational force. A permanent magnet rotating under the action of a DC motor is installed on Motor Shaft; a permanent magnet designed to rotate in a magnetic field is placed in a circular container with water and floats on the surface of the water. Using the above setup, experimental methods and procedures based on this research can be used to observe the rotational behaviour of a permanent magnet in a magnetic field, understand the reason for its rotation, and determine the strength of the rotational force of the permanent magnet in the magnetic field.
Non-obstructive azoospermia treatment by autologous bone marrow-derived mesenchymal stromal/stem cells: a non-randomized, open-label phase I clinical trial
Authors: Zhankina Rano , Zhanbyrbekuly Ulanbek , Askarov Manarbek , Jafari Nazanin , Saipiyeva Dana , Sherkhanov Ravil , Akhmetov Daniyar , Afshar Alireza , Hashemi Alireza , Farjam Mojtaba , Tanideh Nader , Aflatoonian Behrouz , Tamadon Amin 
Published: January 2023

Abstract
The authors have requested that this preprint be removed from Research Square.
Cost analysis of a Fracture Liaison Service: a prospective randomized study for secondary prevention after fragility fractures of the hip
Authors: Zinger Gershon , Davidson Amit , Sylvetsky Noa , Levy Yedin , Peyser Amos 
Published: January 2023

Abstract
Background: Fracture liaison services (FLS) have proven to be effective in treating osteoporosis associated with fragility fractures. For patients with fragility fractures of the hip, FLS programs are expected to be cost-effective because of the high risk of re-fracture and the high cost of fracture treatment. In this study we evaluate the essential factors in determining whether the FLS saves or loses more than it costs.
Methods: A prospective-randomized study was done in patients with hip fragility fractures using a hospital-based FLS program in parallel with a cost analysis. Data was generated from a cohort of patients using actual data for FLS effectiveness, individual costs of hip fracture treatment, and medication costs based on an accepted treatment algorithm.
Results: There were 200 patients randomized and 180 analyzed for costs. Results showed that the cost-benefit of the FLS was dependent on the medication used for osteoporosis. Specifically, using the medication algorithm in this study, the loss per patient enrolled in the FLS was $671 for a 2-year period. If intravenous zoledronic acid had been used, then the loss would have been $221. If only oral bisphosphonates had been used, then the FLS would have saved $109 per patient for a 2-year period.
Conclusions: The analysis done here shows that medication cost is the critical component in cost-effectiveness of a FLS program. Additional work needs to be done refining the medication algorithm considering medication costs but individualized to patient needs based on fracture risk.
Trial Registration: NCT02239523
Decision-making power among women of reproductive age towards family planning use and its associated factors: A cross-sectional study in Simiyu region, Tanzania
Authors: Mkuwa Serafina , Shirima Laura J , Misungwi Gaspery , Mushy Stella E. , Sirili Sirili Nathanael , Ngalesoni Frida N 
Published: January 2023

Abstract

Background: One of the Sustainable Development Goals (SDGs) to be achieved by 2030 is to empower women in decision-making. It is universally agreeable that women's decision-making power influences their use of family planning. However, due to disparities in social and cultural norms and beliefs, the percentage of women with decision-making power varies across societies. Furthermore, unintended pregnancies and unsafe abortions have remained a public health concern, with serious consequences such as death, physical and mental complications, as well as social and economic problems for a woman and her family
Objective: To assess women’s decision-making power towards contraceptive use and its associated factors in Simiyu region.
Methodology: The study utilizes data from a cross-sectional study conducted by Amref Health Africa among women of reproductive age in the Simiyu region. An interviewer-administered questionnaire was used for data collection. Stata 15 was used for data analysis. Categorical variables were summarized using frequency and percentage. The Chi-square test was used to compare the proportion of women’s decision-making power across independent variables. To identify factors associated with women's decision-making power regarding contraceptive use, a multinomial logistic regression model was used.
Results: A total of 917 women were investigated. Of these, 304 (33.1%) reported making their own decision on contraceptive use, 421 (45.9%) made a joint decision with their spouse, and 192 (20.9%) had their decision made by another person. Age, marital status, previous use of contraceptives, husbands using force for sex, and family planning being considered as women's health issues were all associated with women's decision-making power.
Conclusion; The findings of this study underscores that one in every five women has no decision on contraceptive use. It is high time for early women empowerment interventions, particularly among young women, to strengthen, promote, and encourage their decision-making on general health issues, particularly contraceptive use. This study calls for a qualitative study to get an in-depth understanding of the socio-cultural issues behind this power dynamic among women.
Maintenance of pluripotency in the entire ectoderm enables neural crest formation
Authors: Pajanoja Ceren , Hsin Jenny , Olinger Bradley , Schiffmacher Andrew , Abrams Shaun , Dapkunas Arvydas , Zainul Zarin , Doyle Andrew , Martin Daniel , kerosuo Laura 
Published: January 2023

Abstract
The ability of the pluripotent epiblast to contribute progeny to all three germ layers is thought to be lost after gastrulation. The later-forming neural crest (NC) rises from ectoderm and it remains poorly understood how its exceptionally high stem-cell potential to generate mesodermal- and endodermal-like cells is obtained. We monitored transcriptional changes from gastrulation to neurulation using single-cell-Multiplex-Spatial-Transcriptomics (scMST) complemented with RNA-sequencing. Unexpectedly, we find maintenance of undecided Nanog/Oct4-PouV/Klf4-positive pluripotent-like pan-ectodermal stem-cells spanning the entire ectoderm late in the neurulation process with ectodermal patterning completed only at the end of neurulation when pluripotency becomes restricted to NC, challenging our understanding of gastrulation. Furthermore, broad ectodermal pluripotency is found at all axial levels unrelated to the NC lineage the cells later commit to, suggesting a general role in stemness enhancement and proposing a mechanism by which the NC acquires its ability to form derivatives beyond “ectodermal-capacity” in chick and mouse embryos.
Psoriatic Disease Classification Based on Exploratory Data Analysis
Authors: Jiji Wiselin , S.V. Anandhi 
Published: January 2023

Abstract
Psoriasis is caused because of the problem in immune system that that causes a rash with itchy, scaly patches, commonly occur on the knees, elbows, trunk and scalp. This study aims to diagnose Psoriasis and its type through clinical data. A framework has been developed to carry out this task in three phases. Initially preprocessing operation had been performed followed by Exploratory Data Analysis (EDA) is used to gain knowledge about the dataset by using statistical graphics and data visualization mechanism. Here, promising features are selected using various discriminatory techniques Conjoint Analysis, Correlation analysis, Interdependence of pairs, Discriminant Analysis, Analysis of Variance. Best discriminant features were given input to Adaboost classifier to classify into six psarosisi types. Finally, performance analysis had been made and compared with recent works with the accuracy of 98%
Enzymatic Preparation of Mushroom by-Product Protein Hydrolysates (Mb-PPHs).
Authors: Inca-Torres Alberto Renato , Aguilera-Velázquez José Raúl , Urbina-Salazar Anabell del Rocío , Carbonero Pilar , Navarro Isabel Moreno , Palomas Juan Bautista 
Published: January 2023

Abstract
The excessive use of chemical fertilizers can cause severe environmental damage. In recent decades, the application of biostimulants to improve soil composition and stimulate plant growth has contributed significantly to environmental preservation. In this paper, we studied the production and characterization of an amino acid/peptide-enriched biostimulant using edible mushroom (Agaricus bisporus) by-products (tails and nonmarketable mushrooms) as raw materials and commercial proteases as hydrolytic agents. A single hydrolytic process using four different endoproteases, Alcalase®, L-450, Flavourzyme® or papain, and a sequential hydrolytic process using two proteases, an endoprotease and an exoprotease, Alcalase®+Flavourzyme® or L-450 + Flavourzyme), were conducted. A preevaluation of potential plant biostimulants was also carried out, testing the biostimulant capacity of single and sequential Mb-PPHs to stimulate maize seed germination and root growth, as well as the evaluation of the vigor index (VI), with very promising results.
Prevalence of asymptomatic diastolic dysfunction among Type 2 Diabetes Mellitus patients presenting to a tertiary care diabetic clinic in Sri Lanka
Authors: B Herath R.R.G.C.S. , Hirimuthugoda Lasantha Krishan 
Published: January 2023

Abstract
Identification of diastolic dysfunction among patients diagnosed with Type 2 Diabetes Mellitus alarms health care providers to prevent progression of heart failures while at the early stage. Little evidence exists by assessing and determining the cardiac diastolic dysfunction among type 2 diabetic patients with preserved left ventricular ejection fraction and clinically asymptomatic with no overt symptoms or signs of heart failure can help clinicians to recommend early treatments. Between the periods of 2019–2020, total number 59 patients with T2DM attending Diabetic clinics, National (Tertiary) hospital, Colombo, Sri Lanka were assigned. Patients related factors and disease related factors were assessed using interviewer-administered questionnaire with blood investigations of FBS, Lipid profile and Hb levels. Logistic regression model used to assess relationships following the goodness-of-fit with Hosmer–Lemeshow (p = 0.9) and Nagelkerke R (0.22). Among 59 participants, 23.7% and 10.2% of subjects were found to be having grade 1 and grade 2 diastolic dysfunction respectively. Univariate analysis with chi-square reported no particular significance association of diastolic dysfunction over patient’s factors or selected factors of disease status. The final risk-prediction-model was used to estimate the probabilities of diastolic dysfunction with selected factors of DM was not found any significance (p < 0.05). Benefits observed in this study were to recommend assessing diastolic dysfunction at patient’s early stages of DM, irrespective of their disease status and patient’s factors.
Hydrophobic Molecules and Hemodialysis Treatment: ESRD as a Renohepatic Toxic State
Authors: L. Russo 
Published: January 2023

Abstract
INTRODUCTION AND AIMS: Despite technological advances, the mortality of end-stage renal disease (ESRD) remains high. Uremic toxicity is due to a series of molecules, and not all of them are easily dialyzable. Several uremic hydrophobic toxins have classically been identified. Hydrophobic molecules (HPHM) are also present in the plasma of patients with several toxic syndromes. Fluorescence is a characteristic of many aromatic compounds. The total fluorescence of the hydrophobic fraction of plasma has been studied before and after hemodialysis in patients with ESRD.
METHODS: Ten patients treated with a 3 times/week regimen of hemodialysis for ESRD were under study. Plasma samples were taken at the beginning and at the end of the dialytic process.
One milliliter of plasma was extracted with 5 ml. of ether. Fluorescence of the ether fraction was determined with a digital filter fluorometer (excitation 300-400 nm. Emission >400 nm). The results were expressed in fluorescence arbitrary units (AU). Fivecontrol patients without renal insufficiency were also evaluated.
RESULTS: The results are shown in Figures 1, 2 and 3. Five patients had a normal predialysis value (comparable to controls) of hydrophobic fluorescence (mean 15.2 AU, SD 1.9 AU) (Group A). In 5 patients, high values of fluorescence were recorded (mean 73.2 AU, SD 39.0 AU) (Group B). A definite, postdialysis decrease fluorescence was shown in only 2 patients in Group B. In all the other patients, no significant removal of HPHM was reported.
CONCLUSIONS: In this preliminary study, two subpopulations of dialytic patients were identified. Fifty percent of patients show values compatible with a renohepatic toxic state(RHeTS). Hemodialysis has variable efficacy in the removal of different hydrophobic uremic toxins.
One-Week External Beam Partial Breast Irradiation: Survival and Toxicity Outcomes
Authors: Colciago Riccardo Ray , Rocca Eliana La , Giandini Carlotta , Mateo Alicia Rejas , Bedini Nice , Capri Giuseppe , Folli Secondo , Lozza Laura , Meroni Silvia , Pignoli Emanuele , Rancati Tiziana , Arcangeli Stefano , De Santis Maria Carmen 
Published: January 2023

Abstract
Purpose According to ASTRO and ESTRO guidelines, external beam Partial Breast Irradiation (PBI) is a valid option for early-stage Breast Cancer patients. Nevertheless, there is lack of consensus about the best treatment schedule.
METHODS We retrospectively analysed data of female patients treated at our institution from 2013 to 2022 with adjuvant “one-week" partial breast irradiation. Clinical Target Volume (CTV) was an isotropic expansion of 15 mm from the tumour bed (identified as the breast tissue between surgical clips). The treatment schedule was 30 Gy delivered with VMAT in 5 daily fractions. The primary endpoint was Local Control (LC). Disease Free Survival (DFS), Overall Survival (OS) and safety were secondary endpoints.
RESULTS Three hundred eighty-one patients with a median age of 69 (33 – 91) years were included in the study. One hundred ninety-two (50.4%) of the cases were left-sided breast; 360 (94.5%) were invasive ductal carcinomas, 368 (96.6%) were G1 or 2, and 378 (99.2%), were Luminal-like. After a median follow-up of 28 (6 – 104) months, 7 patients (2.0%) developed a local recurrence, of which two were “In field”. Three-year LC, DFS and OS actuarial rates were 97.5% (95% C.I. 96.2% – 98.8%), 95.7% (95% C.I. 94.2% - 97.2%), and 96.9% (95% C.I. 95.7% – 98.1%) respectively. No ≥ grade 3 acute/late toxicities were reported. 10 (2.9%) patients experienced grade 2 late toxicities. Five (1.5%) patients reported late cardiac major events, although 4 of them were treated on the right breast. Three (0.9%) late pulmonary toxicities were detected. One hundred-eight (30.8%) patients reported fat necrosis. Good or Excellent cosmetic evaluation following the Harvard Scale was reported in 252 (96.9%) cases by the physicians while in 241 (89.2%) cases by the patients.
CONCLUSION “One-week” PBI is effective and safe, and this schedule is a valid option for highly selected early breast cancer patients.
LINC00908 promotes malignant progression and glycolysis in lung adenocarcinoma via interactions with DDX54 and RFX2
Authors: Yang Xuhui , Zhao Jiahua , Zhang Yang , Zhang Lin , Wang Lijie , Zhang Fan , Han Xiao , Tao Haitao , Li Chenxi , Zhu Xiang , Hu Yi 
Published: January 2023

Abstract
Lung adenocarcinoma (LUAD) is one of the leading causes of cancer-related death worldwide. We identified a specific LncRNA, LINC00908, was downregulated in LUAD tissues and associated with good outcome. LINC00908 inhibited glycolysis by regulating the expression of the DEAD-box54 (DDX54), which was screened by a nine-gene risk signature related to glycolysis and positively correlated with parts of glycolysis-related genes. DDX54 was also experimental verified that regulate nine key glycolytic enzymes, thereby affecting the level of glycolysis in LUAD. Further, the expression of LINC00908 in LUAD tumorigenesis was modulated by a transcription factor, RFX2. The RFX2/LINC00908/DDX54 axis regulated LUAD tumor growth, migration, invasion, cell apoptosis and glycolysis both in vitro and in vivo. These results demonstrated that this axis might be a novel mediator in LUAD progress. We might offer a novel therapeutic target for more precise diagnosis and treatment of LUAD.
Epsilon-removal constructions of fuzzy finite automata based on fuzzy matrices
Authors: Ping Li , huanhuan sun , Yanping Yang 
Published: January 2023

Abstract
The equivalence of different forms of automata provides a lot of convenience for us to solve practical problems. Sometimes, for efficient use of a fuzzy finite automaton, it is preferable to remove all ε-transitions since in general they induce a delay in their using, that is, to create an equivalent fuzzy finite automaton with no ε-transition. An epsilon-removal construction method with fuzzy ε-closure of fuzzy finite automata with ε-transitions over lattice-ordered monoids is proposed in Li et al.(2006). In this paper, we define the fuzzy languages accepted by fuzzy fifinite automata with ε-transitions by fuzzy matrices, fuzzy matrices yield the very compact and intuitive representations of fuzzy finite automata with ε-transitions and often very concise proofs about their languages. Next, based on fuzzy matrices, we propose four epsilon-removal constructions of fuzzy finite automata with ε-transitions over lattice-ordered monoids. Furthermore, the conditions of applications for the four epsilon-removal constructions are discussed and compared in detail, then we study the four epsilon-removal constructions of fuzzy finite automata over more general algebraic structures, such as semirings, and we give some examples to illustrate the applications of the four epsilon-removal constructions.