bluuebunny/crossref_metadata_2025_split huggingface dataset:
Observation of the therapeutic effect of apatinib in advanced platinum-resistant recurrent epithelial ovarian cancer
Authors: Pan Zhongmian , Luo Zhongbin , He Hongying , Chen Yujie , Zhao Bingbing , Yang Zhijun , Li Li 
Published: February 2023

Abstract
Background
Apatinib is an oral anti-angiogenic drug that mainly targets vascular endothelial growth factor receptor 2 (VEGFR-2) and is widely used in a variety of solid tumours. The purpose of this study is to evaluate the clinical efficacy and safety of apatinib in patients with advanced platinum-resistant relapsed epithelial ovarian cancer (EOC).

Methods
A retrospective analysis was performed, the clinical data of patients with stage IIIC-IV platinum-resistant relapsed EOC between January 2014 and May 2018 were collected. The objective response rate (ORR), disease control rate (DCR), progression-free survival (PFS), and overall survival (OS) were reviewed and evaluated. The propensity score matching (PSM) method was used to determine the final case data included in this study.

Results
According to 1:2 propensity matching, 108 patients were finally taken into account: 36 in the apatinib group and 72 in the control group. The follow-up ended in January 2019, and the median follow-up time was 28 months. In the apatinib group, ORR was 30.56% and DCR was 66.67%, whereas in the control group, ORR was 16.67% and DCR was 44.44%. In the apatinib group, median PFS was 6.0 months (95% CI 3.69–8.31) and median OS was 15.8 months (95% CI 6.99–24.6), while in the control group, median PFS was 3.3 months (95% CI 2.44–4.16) and median OS was 9.2 months (95% CI 6.3–12.06); the difference was statistically significant (P < 0.05). Apatinib was more effective than conventional chemotherapy in reducing the risk of PFS [HR 0.40 (95% CI 0.22–0.76), P = 0.0017] and OS [HR 0.40 (95% CI 0.21–0.73), P = 0.002]. Multivariate Cox analysis showed that the course of treatment and decrease in serum CA125 levels are independent risk factors for PFS in patients, while apatinib, the length of treatment course and the location of the lesion are independent risk factors for recurrence affecting the OS of patients. The main grade 3–4 adverse events in the apatinib group were hypertension, hand-foot syndrome, and oral mucosal ulcers, and all adverse events were controllable.

Conclusion
Apatinib was found to be both safe and effective in patients with advanced platinum-resistant relapsed EOC. More in-depth clinical research and applications should be carried out.
Pitfalls and opportunities for applying latent variables in single-cell eQTL analyses
Authors: Xue Angli , Yazar Seyhan , Neavin Drew , Powell Joseph E. 
Published: February 2023

Abstract
Using latent variables in gene expression data can help correct unobserved confounders and increase statistical power for expression quantitative trait Loci (eQTL) detection. The probabilistic estimation of expression residuals (PEER) and principal component analysis (PCA) are widely used methods that can remove unwanted variation and improve eQTL discovery power in bulk RNA-seq analysis. However, their performance has not been evaluated extensively in single-cell eQTL analysis, especially for different cell types. Potential challenges arise due to the structure of single-cell RNA-seq data, including sparsity, skewness, and mean-variance relationship. Here, we show by a series of analyses that PEER and PCA require additional quality control and data transformation steps on the pseudo-bulk matrix to obtain valid latent variables; otherwise, it can result in highly correlated factors (Pearson's correlation r = 0.63 ~ 0.99). Incorporating valid PFs/PCs in the eQTL association model would identify 1.7 ~ 13.3% more eGenes. Sensitivity analysis showed that the pattern of change between the number of eGenes detected and fitted PFs/PCs varied significantly in different cell types. In addition, using highly variable genes to generate latent variables could achieve similar eGenes discovery power as using all genes but save considerable computational resources (~ 6.2-fold faster).
Intraspecific variation of Quercus ilex L. seed morphophysiological traits in Tunisia reveals a trade-off between seed germination and shoot emergence rates along a thermal gradient
Authors: Amimi Nabil , Ghouil Hana , Zitouna-Chebbi Rim , Joët Thierry , Ammari Youssef 
Published: February 2023

Abstract
Key message
Quercus ilex populations from cold habitats display a large lag between seed germination and shoot emergence time, favouring avoidance of late frost events. Populations from mild habitats show the fastest seed germination and shoot emergence rates at moderate temperatures, enabling them to synchronize germination in the late winter-early spring period and a rapid seed-to-seedling transition, during the favourable rainy period.

Context
Quercus ilex is the most abundant and representative Mediterranean oak species. Identifying and describing intraspecific variation in seed traits is necessary to characterize the germination niche, and to elucidate drivers of species’ range.

Aims
In order to identify adaptations to local environments that may reflect ecological strategies for stress avoidance and seed survival, we tested under common and optimal conditions whether seed functional traits vary, in Quercus ilex subsp. rotundifolia Lam., along climatic gradients within its distribution range in Tunisia.

Methods
We have explored variations in seed morphological traits, desiccation sensitivity level, germination and shoot emergence rates under different controlled temperature conditions, among 15 populations of Q. ilex sampled throughout the Tunisian distribution of the species.

Results
Significant between-populations differences were observed for morphological seed traits but no relationships could be established with the climate of the sampling sites. In contrast, key physiological traits varied significantly with elevation and temperature. Specifically, mild temperatures in lowland regions were associated with higher seed moisture content, fast germination and shoot emergence rates at moderate temperatures (13 °C) for germination. Seeds of Q. ilex populations from cold sites displayed the fastest germination rates at low temperatures (5 °C) as well as the greatest lag between seed germination and shoot emergence time.

Conclusion
Intraspecific variation in seed physiological traits is significantly associated with local climate. This functional diversity should be considered when evaluating germplasm and predicting suitability for reforestation and assisted migration programs.
An inexact multiblock alternating direction method for grasping-force optimization of multifingered robotic hands
Authors: Zhang Yaling , Mu Xuewen 
Published: February 2023

AbstractIn this paper, we present an inexact multiblock alternating direction method for the point-contact friction model of the force-optimization problem (FOP). The friction-cone constraints of the FOP are reformulated as the Cartesian product of circular cones. We focus on the convex quadratic circular-cone programming model of the FOP, which is an exact cone-programming model. Coupled with the separable convex quadratic objective function, we recast the circular-cone-programming model as a multiblock separable cone model. A parallel inexact multiblock alternating direction method is used to solve the FOP. We prove the global convergence of the proposed method. Simulation results of the three-fingered FOP are reported, which verified the efficiency of the proposed method.
Development and Psychometric Validation of the Mental Health-Related Barriers and Benefits to EXercise (MEX) Scale in Healthy Adults
Authors: Connolly Madeleine L. , Bowden Stephen C. , Pascoe Michaela C. , Van Dam Nicholas T. 
Published: February 2023

Abstract
Background
Physical exercise has been shown to reduce anxiety and depression symptoms, the most common mental health disorders globally. Despite the benefits of exercise in anxiety and depression, the symptoms of these disorders may directly contribute to a lack of engagement with exercise. However, mental health-related barriers and benefits to exercise engagement have not been addressed in quantitative research. We introduce the development and psychometric validation of the Mental health-related barriers and benefits to EXercise (MEX) scale.

Methods
Three samples were collected online prospectively (sample 1 n = 492; sample 2 n = 302; sample 3 n = 303) for scale refinement and validation with exploratory and confirmatory factor analysis. All participants were generally healthy adults, aged 18–45, and had no history of severe mental illness requiring hospitalization and no physical disability impacting over 50% of daily function.

Results
We identified a 30-item, two-factor model comprising 15 barrier and 15 benefit items. Overall model fit was excellent for an item-level scale across the three samples (Comparative Fit Index = 0.935–0.951; Root-Mean-Square Error of Approximation = 0.037–0.039). Internal consistency was also excellent across the three samples (α = 0.900–0.951). The barriers subscale was positively correlated with symptoms of anxiety, depression and stress, and negatively correlated with measures of physical activity and exercise engagement. The benefits subscale was negatively correlated with symptoms of anxiety, depression and stress, and positively correlated with measures of physical activity and exercise engagement.

Conclusion
The MEX is a novel, psychometrically robust scale, which is appropriate for research and for clinical use to ascertain individual and/or group level mental health-related barriers and benefits to exercise.
The Relative Importance of Training and Social Support for Runners’ Performance: A Cross-Sectional Study
Authors: Thuany Mabliny , Vieira Douglas , de Paula Henrique , Nikolaidis Pantelis T. , Scheer Volker , Weiss Katja , Cuk Ivan , Knechtle Beat , Gomes Thayse Natacha 
Published: February 2023

Abstract
Background
Running participation/performance is a complex system. Understanding the variables associated with these behaviors may help to increase population physical activity and improve performance. This study aimed to investigate social and training variables important for running performance using a network approach.

Methods
This cross-sectional study sampled 1151 non-professional Brazilian runners of both sexes (women, 38.2%; men, 61.7%). A questionnaire was available for eligible participants using an online platform, and information regarding training (volume and running pace) and social variables (participation in a running event, participation in a running group, influence on running, runners in the family, and childhood sport) related to runners’ performance was obtained. The Chi-square test and network model were estimated by sex.

Results
Training characteristics tend to be clustered. For both sexes, the training volume node presented the highest expected influence in the network (1.69 for women and 2.16 for men). Centrality indicators of social variables show that sports childhood participation and the presence of runners in the family were the most important nodes of network connection for women and men, respectively.

Conclusion
Based on these findings, it was concluded that sports participation during childhood and the practice of running by other family members were important factors to connect variables in the network. These findings have practical applications for health policymakers, highlighting the need to develop educational programs to increase sports participation during childhood and within families.
Cancer Screening in the United States During the Second Year of the COVID-19 Pandemic
Authors: Star Jessica , Bandi Priti , Siegel Rebecca L. , Han Xuesong , Minihan Adair , Smith Robert A. , Jemal Ahmedin 
Published: February 2023

PURPOSE To examine whether cancer screening prevalence in the United States during 2021 has returned to prepandemic levels using nationally representative data. METHODS Information on receipt of age-eligible screening for breast (women age 50-74 years), cervical (women without a hysterectomy age 21-65 years), prostate (men age 55-69 years), and colorectal cancer (men and women age 50-75 years) according to the US Preventive Services Task Force recommendations was obtained from the 2019 and 2021 National Health Interview Survey. Past-year screening prevalence in 2019 and 2021 and adjusted prevalence ratios (aPRs), 2021 versus 2019, with their 95% CIs were calculated using complex survey logistic regression models. RESULTS Between 2019 and 2021, past-year screening in the United States decreased from 59.9% to 57.1% (aPR, 0.94; 95% CI, 0.91 to 0.97) for breast cancer, from 45.3% to 39.0% (aPR, 0.85; 95% CI, 0.82 to 0.89) for cervical cancer, and from 39.5% to 36.3% (aPR, 0.9; 95% CI, 0.84 to 0.97) for prostate cancer. Declines were most notable for non-Hispanic Asian persons. Colorectal cancer screening prevalence remained unchanged because an increase in past-year stool testing (from 7.0% to 10.3%; aPR, 1.44; 95% CI, 1.31 to 1.58) offset a decline in colonoscopy (from 15.5% to 13.8%; aPR, 0.88; 95% CI, 0.83 to 0.95). The increase in stool testing was most pronounced in non-Hispanic Black and Hispanic populations and in persons with low socioeconomic status. CONCLUSION Past-year screening prevalence for breast, cervical, and prostate cancer among age-eligible adults in the United States continued to be lower than prepandemic levels in the second year of the COVID-19 pandemic, reinforcing the importance of return to screening health system outreach and media campaigns. The large increase in stool testing emphasizes the role of home-based screening during health care system disruptions. [Media: see text]
Integration of Remote Symptom and Biometric Monitoring Into the Care of Adult Patients With Cancer Receiving Chemotherapy—A Decentralized Feasibility Pilot Study
Authors: Offodile Anaeze C. , Delgado Domenica , Lin Yu-Li , Geyen Danielle , Miller Christopher J. , Jain Sanchita , Finder Janice P. , Shete Sanjay , Fossella Frank V. , Overman Michael J. , Peterson Susan K. 
Published: February 2023

PURPOSE: Although electronic patient-reported outcomes (ePROs) are efficacious in symptom management, much is unknown about the utility of vital signs surveillance. We examined the feasibility of a remote patient monitoring platform that integrates ePROs and biometrics into the ambulatory management of symptom burden. METHODS: Using a decentralized workflow, patients with gastrointestinal or thoracic cancer were approached for a 1-month study. Patients reported symptom burden via ePROs and biometrics (blood pressure, oxygen saturation, pulse, weight, and temperature) using bluetooth-enabled devices daily. Alerts on the basis of prespecified thresholds were managed via nurse-led triage. Adherence was defined as the completion of > 70% of daily symptom and biometric reporting requirements. Pilot acceptability, appropriateness, and feasibility were measured using validated instruments. Net promoter score, system usability scale, and emergency department (ED) admission rates were collected. RESULTS: Over 8 months, 36 patients were enrolled and 25 (60% gastrointestinal) completed the study. Participants had a mean age of 58.0 years, mean Eastern Cooperative Oncology Group score of 0.88, were 52% female, and predominantly had stage IV or recurrent disease (72%). Program adherence was 73% and associated with high acceptability (4.63), feasibility (4.56), and appropriateness (4.46). System usability scale and net promoter score scores were 88 and 55, respectively. Seventy percent of alerts were generated by biometrics, 28% for symptoms, and 2% were patient-initiated communication. Finally, the ED visitation rate over the pilot period was 8%. CONCLUSION: Our remote patient monitoring pilot program was highly acceptable, feasible, and appropriate. It had high rates of patient adherence and satisfaction and was associated with low ED visitation rates.
Impact Of Physical Activity And Health Education On The Development Of Depression
Authors: Kulbat Aleksandra , Karwańska Aleksandra , Kulbat Mateusz , Brzychczy Piotr , Majcher Magdalena , Górska Dominika , Sierpień Małgorzata , Majcher Monika , Świercz Kamila , Pikulicka Agata 
Published: February 2023

Depression is a common mental health disorder that affects the majority of the population. The exact cause of depression is not fully understood, but various factors such as genetics, environmental stressors, and psychological factors are believed to play a role. Due to the complexity of the etiopathogenesis of depression, the selection of appropriate therapeutic management is sometimes complicated. Treatment for depression typically involves a combination of medication and psychotherapy. Antidepressant medication can help alleviate symptoms by regulating neurotransmitters in the brain, while psychotherapy can help individuals understand and change negative thoughts and behaviors.
Physical activity, such as sport, has been shown to have a positive impact on mental health and can help alleviate symptoms of depression. Exercise releases endorphins, reducing stress and improving mood. Health education can also play a role in preventing and managing depression by raising awareness, reducing stigma, and teaching individuals coping skills to maintain good mental health.
Better Together! The Consumer Implications of Delivery Consolidation
Authors: Wagner Laura , Calvo Eduard , Amorim Pedro 
Published: February 2023

Problem definition: Online retailers often receive customer orders comprising several products of differing origins. To fulfill these orders, retailers must ship multiple parcels from different locations and—unless they are grouped somewhere along the supply chain—these may reach the customer’s doorstep one by one. Academic/practical relevance: We conjecture here that receiving products sequentially instead of all together affects a consumer’s reaction to her purchases, possibly influencing—for good or ill—her decision to return products, as well as her overall service satisfaction. We use two-year granular data from an online fashion marketplace to test this hypothesis and characterize consumer behavioral responses to delivery consolidation and examine how it impacts supply chain stakeholders. Methodology: To achieve causal inference, we exploit the fact that the couriers used by the focal marketplace gather together certain parcels for reasons related more to the timing of their arrival than their actual customers, thereby exogenously consolidating the delivery of some orders. We construct a balanced sample of matched twin multiproduct orders that are alike in all respects except their delivery: consolidated (all parcels delivered jointly) versus otherwise (split). Results: We find that delivery consolidation benefits the marketplace and all its suppliers. By eliminating the stress associated with split deliveries, delivery consolidation pleases consumers as it leads to fewer returns and higher overall satisfaction. Managerial implications: Delivering all products in an order together, even if later, reduces the probability of a return, which improves the financial performance of the marketplace and its suppliers and reduces reverse logistics. Our results suggest that in our context, delivery speed matters less than the convenience of receiving all ordered goods in a single delivery, and we provide directions for adapting logistics strategies accordingly. Our empirical findings also imply that the return decisions of multiple products purchased at once should not be considered to be independent. Finding tractable ways of modeling this feature will be necessary in further driving retail practice through theoretical research that accounts for the behavioral implications of delivery consolidation when optimizing fulfillment decisions. Supplemental Material: The online appendix is available at https://doi.org/10.1287/msom.2023.1200 .
The integration of simulation into a post registration neurological course: a phenomenological research study
Authors: Derbyshire Julie Ann , Hill Barry , Diamond-Fox Sadie 
Published: February 2023

Background:Simulation in healthcare education is becoming increasingly popular. However, there is limited evidence of simulation in post registration education or in neurological practice. This article reports on the introduction of simulation into a neurological course for registered nurses and the value of this from the learner perspective.Aim:To explore the experiences of nurses who participated in a neurological simulation activity.Methods:A phenomenological research design was used to explore the experiences of 10 registered nurses using semi-structured interviews.Findings:A total of four key themes were generated from the analysis: being in the spotlight, reality of simulation, theory to practice interface, and learning and working with others.Conclusion:The lived experience of the participants of this study has shown that neuro-simulation is valued as a teaching strategy to consolidate learning, with low-fidelity simulation receiving the most positive feedback owing to its authentic nature. A review of the high-fidelity session, where the simulation should become more realistic and use smaller, interprofessional groups, needs to be considered.
SUCCESS OF DAIR VERSUS REVISION IN EARLY AND LATE PJIS IN PRIMARY TKA: A PROSPECTIVE STUDY OF 251 CASES
Authors: Zhu M. , Rahardja R. , Davis J.S. , Manning L. , Metcalf S. , Young S.W. 
Published: February 2023

The optimum indications for debridement, antibiotics and implant retention (DAIR) are unclear. Previous studies have demonstrated higher success rate of DAIR within one year of the primary arthroplasty. This study aimed to compare the success rate of DAIR vs revision in “early” and “late” infections to provide guidance for clinical decision making.The Prosthetic Joint Infection in Australia and New Zealand Observational (PIANO) cohort prospectively recorded PJIs between July 2014 and December 2017 in 27 hospitals. This study included PIANO patients with first time PJIs occurring after primary TKA. Treatment success was defined as the patient being alive, free from further revision and without clinical or microbiological evidence of reinfection at two years follow-up.“Early” and “late” infections were analyzed separately. Univariate analysis compared demographic and disease specific factors between the DAIR and Revision groups. Multivariate binary logistic regression identified whether treatment strategy and other risk factors were associated with treatment success in “early” and “late” infections.In 117 “early” (<1 year) infections, treatment success rate was 56% in the DAIR group and 54% in the revision group (p=0.878). No independent risk factors were associated with treatment outcome on multivariate analysis.In 134 “late” (>1 year) infections, treatment success rate was 34.4% in the DAIR group and 60.5% in the revision group (OR 3.07 p=0.006). On multivariate analysis, revision was associated with 2.47x higher odds of success (p=0.041) when compared to DAIR, patients with at least one significant co-morbidity (OR 2.27, p=0.045) or with Staphylococcus aureus PJIs (OR 2.5, p=0.042) had higher odds of failure.In “late” PJIs occurring >1 year following primary TKA, treatment strategy with revision rather than DAIR was associated with greater success. Patients with significant comorbidities and Staphylococcus aureus PJIs were at higher risk of failure regardless of treatment strategy.