bluuebunny/crossref_metadata_2025_split huggingface dataset:
A molecular landscape of quiescence and proliferation highlights the role of Pten in mammary gland acinogenesis
Authors: Tomasin Rebeka , Rodrigues Ana Maria , Manucci Antonio Carlos , Bruni-Cardoso Alexandre 
Published: September 2023

ABSTRACT
Cell context is key for cell state. Using physiologically relevant models of laminin-rich extracellular matrix (lrECM) induction of mammary epithelial cell quiescence and differentiation, we provide a landscape of the key molecules for the proliferation–quiescence decision, identifying multiple layers of regulation at the mRNA and protein levels. Quiescence occurred despite activity of Fak (also known as PTK2), Src and phosphoinositide 3-kinases (PI3Ks), suggesting the existence of a disconnecting node between upstream and downstream proliferative signalling. Pten, a lipid and protein phosphatase, fulfils this role, because its inhibition increased proliferation and restored signalling via the Akt, mTORC1, mTORC2 and mitogen-activated protein kinase (MAPK) pathways. Pten and laminin levels were positively correlated in developing murine mammary epithelia, and Pten localized apicolaterally in luminal cells in ducts and near the nascent lumen in terminal end buds. Consistently, in three-dimensional acinogenesis models, Pten was required for triggering and sustaining quiescence, polarity and architecture. The multilayered regulatory circuitry that we uncovered provides an explanation for the robustness of quiescence within a growth-suppressive microenvironment, which could nonetheless be disrupted by perturbations in master regulators such as Pten.
Carbon-Neutral Energy Cycle via Highly Selective Electrochemical Reactions Using Biomass Derivable Organic Liquid Energy Carriers
Authors: Fukushima Takashi , Higashi Manabu , Yamauchi Miho 
Published: September 2023

Abstract
Efficient storage and transport of electric energy is essential to promote the use of renewable energy based electricity. We demonstrate an energy cycle based on highly selective redox reactions between lactic acid (Lac) and pyruvic acid (Pyr), both of which are liquid under ambient conditions and can be obtained from biomass resources, thus realizing a completely low-emission system. As an energy storage device, an electrosynthesis cell (LAEC) for the production of Lac from Pyr was constructed using a membrane electrode assembly (MEA) consisting of a TiO2 cathode catalyst for the electroreduction of Pyr and an IrOx anode catalyst for water oxidation. Our LAEC achieved highly efficient Lac production from 10 M Pyr aqueous solution with Faradaic efficiency (FE) of approximately 100% in the applied voltage range of 1.4–2.4 V, resulting in an energy conversion efficiency of 50% and a current density of −0.4 A cm−2 at 2.0 V. Direct Lac fuel cell (DLAFC) was also constructed and its FE values for the Pyr production reached approximately 100%, enabling direct electronic energy storage in bio-derivative liquid carriers and efficient energy circulation with minimal CO2 emissions.
Case Report: Rehabilitation of missing lower anterior teeth with Maryland bridge
Authors: Pathak Ankita , Dhamande Mithilesh , Sathe Seema , Gujjelwar Smruti 
Published: September 2023

Congenital partial hypodontia is a common disorder, and many treatments have been developed for adolescents, but each has had one or more significant drawbacks. Maryland Bridge, a widely available treatment option, appears to offer great strength and aesthetics. The option is discussed in this article along with a successful application of it. A young male patient reported to us with the chief complaint of missing lower anterior teeth. After examination, clinical findings revealed that the patient was receiving orthodontic treatment and two lateral incisors missing in the lower arch. The patient was diagnosed with congenital partial hypodontia. A treatment plan was decided to rehabilitate the missing teeth with a Maryland Bridge. A treatment conundrum for restorative dentists is the presence of congenitally absent lateral incisors. There are numerous therapy alternatives, none of which are perfect. The outcome of this rehabilitation was aesthetically pleasing appearance, hence serving the required purpose. This article offers Maryland Bridge as a feasible substitute for the patient.
Acid leaching technology for post-consumer gypsum purification
Authors: Castro-Diaz Miguel , Osmani Mohamed , Cavalaro Sergio , Needham Paul , Parker Bill , Lovato Tatiana 
Published: September 2023

Background: Contaminants and water-soluble salts present in mechanically recycled gypsum from refurbishment and demolition (post-consumer) plasterboard waste limit its use as a secondary raw material in plasterboard manufacturing. This research addresses this limitation, developing a novel acid leaching purification technology combined with an improved mechanical pre-treatment for post-consumer gypsum valorization. Methods: Laboratory-scale acid leaching purification was performed with a borosilicate beaker, hot plate, and overhead stirrer. Stuccos were produced after calcination of gypsum at 150 °C for 3 hours. Samples were characterized through X-ray fluorescence, X-ray diffraction, thermal gravimetric analysis, scanning electron microscopy and particle size analysis. Results: Acid leaching at 90 °C for 1 h using a 5 wt% sulfuric acid solution was revealed to be the optimum purification conditions. Stuccos produced from purified gypsum under optimum conditions had similar initial setting times to that of a commercial stucco but with higher water demand, which could be reduced by optimizing the calcination conditions. A magnesium-rich gypsum was precipitated from the wastewater. Conclusions: Purified post-consumer gypsum with > 96 wt% chemical purity and calcium sulfate dihydrate content was produced. The research recommends acid neutralization prior filtration, use of gypsum particles < 2 mm in size, and stirring speed of 50 rpm to reduce the economic and environmental impacts of the acid leaching purification process at industrial scale. The magnesium-rich gypsum could potentially be marketed as soil fertilizer.
Generalized Stochastic Arbitrage Opportunities
Authors: Arvanitis Stelios , Post Thierry 
Published: September 2023

Concepts are introduced and applied for analyzing and selecting arbitrage portfolios in the face of uncertainty about initial positions and risk preferences. A stochastic arbitrage opportunity is defined as a zero-cost investment portfolio that enhances every feasible host portfolio for all admissible utility functions. The alternative to the existence of such investment opportunities is the existence of a solution to a dual system of asset pricing restrictions based on a class of stochastic discount factors. Feasible approaches to numerical optimization and statistical inference are discussed. Empirical results suggest that equity factor investing is appealing for all risk-averse stock investors with a wide range of initial position and sufficiently low transactions costs by mixing multiple factor portfolios with high after-cost appraisal ratios, low mutual correlation, and negative exposures to the relevant host portfolios. These findings weaken the case for risk-based explanations for the profitability of factor investing. This paper was accepted by Kay Giesecke, finance. Supplemental Material: The data files are available at https://doi.org/10.1287/mnsc.2023.4892 .
Coexistence in future optical access networks from an operator’s perspective [Invited]
Authors: Saliou Fabienne , Simon Gaël , Le Huérou Stéphane , Chanclou Philippe , Potet Jérémy , Gaillard Georges , Percevault Ugo , Chevalier Dylan , Zandueta Joseph , Yang Bo , Vagionas Christos , Gatzianas Marios , Kalfas Georgios , Moschos Theodoros , Miliou Amalia , Pleros Nikos 
Published: September 2023

In this paper, we address the challenges related to the simultaneous operation of legacy and future network technologies in passive optical networks (PONs) and point-to-point topologies. We explore the coexistence issues for various user categories, including residential, enterprise, factories, and mobile users. The future access networks will need to accommodate multiple technologies concurrently. Our paper demonstrates how G-PON, XGS-PON, and 50G-PON can coexist on the same optical distribution network using triple coexistence multi-PON modules. However, there are certain limitations that need to be considered, such as achieving a high optical budget and the associated costs, both in terms of monetary investment and CO2 emissions for technology deployment by operators. Additionally, we emphasize the significance of optical line terminals (OLTs) as crucial network components in the future. OLTs play a central role in supporting the traffic evolution with optimal efficiency in terms of throughput, latency, jitter, and adherence to CO2 emission constraints. Finally, we experimentally demonstrate the first assessment, to our knowledge, of a 50G-PON prototype with optical budget reaching 23.9 dB limited by the downstream (DS). Furthermore, we evaluate the potential limitations regarding coexistence by examining the effects of stimulated Raman scattering between the DS of 50G-PON and the upstream of XGS-PON for the first time with real PON systems.
Neuroprognostication value of serum neurofilament light chain for out-of-hospital cardiac arrest: A systematic review and meta-analysis
Authors: Fu Yu , Fan Xiao-Tian , Li Hui , Zhang Ran , Zhang Ding-Ding , Jiang Hao , Chen Zhi-Guo , Zhang Jiang-Tao 
Published: September 2023

Background
Neurofilament light chain (NfL) is a novel biomarker for the assessment of neurological function after cardiac arrest (CA). Although meta-analysis has confirmed its predictive value, it has not conducted a more detailed analysis of its research. We conducted a meta-analysis to evaluate the relationship between serum NfL level and neurological prognosis in patients with spontaneous circulation recovery after CA, and subgroup analysis was conducted according to sample collection time, time to assess neurological function, study design, whether TTM was received, the method of specimen determination, and the presence of neurological disease in patients. To analyze the influence of these factors on the predictive value of serum NfL.

Methods
Published Cochrane reviews and an updated, extended search of MEDLINE, Cochrane Library, Embase, Scopus, ClinicalKey, CINAHL, and Web of Science for relevant studies until March 2022 were assessed through inclusion and exclusion criteria. The standard mean difference and 95% confidence interval were calculated using the random-effects model or fixed-effects model to assess the association between one variable factor NfL level and the outcome of CA patients. Subgroup analysis according to sample collection time was performed. The prognosis analysis and publication bias were also assessed using Egger’s and Begg’s tests.

Results
Among 1209 related articles for screening, 6 studies (1360 patients) met the inclusion criteria and were selected for meta-analysis. The level of serum NfL in the good prognosis group (CPC1-2, CPC: cerebral performance category score) was significantly lower than that in the poor prognosis group (CPC3-5)SMD(standardized mean difference) = 0.553, 95%CI(confidence interval) = 0.418–0.687, I2 = 65.5% P<0.05). And this relationship also exists at each sampling time point (NfL specimens were collected on admission: SMD:0.48,95%CI:0.24–0.73; Samples were collected 24 hours after CA: SMD:0.60,95%CI:0.32–0.88;Specimens were obtained 48 hours after CA: SMD:0.51, 95%CI:0.18–0.85;Specimens were obtained 72 hours after CA: SMD:0.59, 95%CI:0.38–0.81).

Conclusion
NfL may play a potential neuroprognostication role in postcardiac arrest patients with spontaneous circulation, regardless of when the sample was collected after CA.
Childhood infection burden, recent antibiotic exposure and vascular phenotypes in preschool children
Authors: Yu Angela , Jansen Maria A. C. , Dalmeijer Geertje W. , Bruijning-Verhagen Patricia , van der Ent Cornelis K. , Grobbee Diederick E. , Burgner David P. , Uiterwaal Cuno S. P. M. 
Published: September 2023

Background
Severe childhood infection has a dose-dependent association with adult cardiovascular events and with adverse cardiometabolic phenotypes. The relationship between cardiovascular outcomes and less severe childhood infections is unclear.

Aim
To investigate the relationship between common, non-hospitalised infections, antibiotic exposure, and preclinical vascular phenotypes in young children.

Design
A Dutch prospective population-derived birth cohort study.

Methods
Participants were from the Wheezing-Illnesses-Study-Leidsche-Rijn (WHISTLER) birth cohort. We collected data from birth to 5 years on antibiotic prescriptions, general practitioner (GP)-diagnosed infections, and monthly parent-reported febrile illnesses (0–1 years). At 5 years, carotid intima-media thickness (CIMT), carotid artery distensibility, and blood pressure (BP) were measured. General linear regression models were adjusted for age, sex, smoke exposure, birth weight z-score, body mass index, and socioeconomic status.

Results
Recent antibiotic exposure was associated with adverse cardiovascular phenotypes; each antibiotic prescription in the 3 and 6 months prior to vascular assessment was associated with an 18.1 μm (95% confidence interval, 4.5–31.6, p = 0.01) and 10.7 μm (0.8–20.5, p = 0.03) increase in CIMT, respectively. Each additional antibiotic prescription in the preceding 6 months was associated with an 8.3 mPa-1 decrease in carotid distensibility (-15.6– -1.1, p = 0.02). Any parent-reported febrile episode (compared to none) showed weak evidence of association with diastolic BP (1.6 mmHg increase, 0.04–3.1, p = 0.04). GP-diagnosed infections were not associated with vascular phenotypes.

Conclusions
Recent antibiotics are associated with adverse vascular phenotypes in early childhood. Mechanistic studies may differentiate antibiotic-related from infection-related effects and inform preventative strategies.
Interventions promoting recovery from depression for patients transitioning from outpatient mental health services to primary care: Protocol for a scoping review
Authors: Aggestrup Anne Sofie , Martiny Frederik , Faurholt-Jepsen Maria , Hvenegaard Morten , Christensen Robin , Davidsen Annette Sofie , Martiny Klaus 
Published: September 2023

Introduction
Patients with severe Major Depressive Disorder (MDD) have an increasing risk of new psychiatric hospitalizations following each new episode of depression highlighting the recurrent nature of the disorder. Furthermore, patients are not fully recovered at the end of their treatment in outpatient mental health services, and residual symptoms of depression might explain why patients with MDD have a high risk of relapse. However, evidence of methods to promote recovery after discharge from outpatient mental health services is lacking. The proposed scoping review aims to systematically scope, map and identify the evidence and knowledge gaps on interventions that aims to promote recovery from MDD for patients transitioning from outpatient mental health services to primary care.

Materials and methods
The proposed scoping review will follow the latest methodological guidance by the Joanna Briggs Institute (JBI) in tandem with the Preferred Reporting Items for Systematic reviews and Meta-Analysis—extension for Scoping Reviews (PRISMA-ScR) checklist. The review is ongoing. Four electronic databases (Medline via PubMed, PsycINFO, CINAHL, and Sociological Abstracts) were systematically searched from 20 January 2022 till 29 March 2022 using keywords and text words. The review team consists of three independent screeners. Two screeners have completed the initial title and abstract screening for all studies retrieved by the search strategy. Currently, we are in the full text screening phase. Reference lists of included studies will be screened, and data will be independently extracted by the review team. Results will be analyzed qualitatively and quantitatively.

Discussion
The chosen methodology is based on the use of publicly available information and does not require ethical approval. Results will be published in an international peer reviewed scientific journal, at national and international conferences and shared with relevant authorities.

Registration
A pre-print has been registered at the medRxiv preprint server for health sciences (doi.org/10.1101/2022.10.06.22280499).
Evaluation of the hoof centre-of-pressure path in horses affected by chronic osteoarthritic pain
Authors: Buser Larissa Irina , Torelli Nathan , Andreis Sabrina , Witte Stefan , Spadavecchia Claudia 
Published: September 2023

IntroductionThe Centre of Pressure (COP) is the single point summarising all forces transferred to the hoof during the stance phase of a stride. COP path (COPp) is the trajectory that COP follows from footstrike to lift-off. Aim of the present study was to characterize the COP and COPp in horses affected by osteoarthritis and chronic lameness.Materials and methodsSeventeen adult horses with a diagnosis of osteoarthritis and single limb chronic lameness were recruited. The COP was recorded using a wireless pressure measuring system (TekScan®) with sensors taped to the hooves (either fore- or hind limb, depending on lameness location). The COPp coordinates were further processed. Procrustes analysis was performed to assess the variability of single strides COPp and average COPp among strides, gaits, and limbs by calculating Procrustes distances (D-values). A linear mixed-effects model was run to analyse D-values differences for lame and sound limbs. Additionally, average COPp D-values and COPp hoofprint shape indices were compared for lame and sound limbs with the Signed Rank Test.ResultsAt walk and trot the single-stride COPp D-values were significantly lower in lame than in sound limbs (marginal effects p<0.001). Analysis of the average COPp D-values confirmed that each hoof COPp is highly consistent with itself over subsequent trials but is different from the contralateral. COPp and hoofprint shape indices did not differ between sound and lame limbs. Footstrike and lift-off within the hoofprint showed that most horses had lateral footstrike and lift-off, independently of the lameness location.ConclusionOur findings are in line with previous observations that COPp are highly repetitive and characteristic for each horse and limb. There seems to be a further decrease in COPp variability in the presence of a painful limb pathology.
Ganos Aero: A Cloud-Native System for Big Raster Data Management and Processing
Authors: Xiao Fei , Xie Jiong , Chen Zhida , Li Feifei , Chen Zhen , Liu Jianwei , Liu Yinpei 
Published: September 2023

The development of Earth Observation technology contributes to the production of massive raster data. It is vital to manage and conduct analytical tasks on the raster data. Existing solutions employ dedicated systems for the raster data management and processing, respectively, incurring problems such as data redundancy, difficulty in updating, expensive data transferring and transformation, etc. To cope with these limitations, this demonstration presents Ganos Aero, a cloud-native system for big raster data management and processing. Ganos Aero proposes a unified raster data model for both the data management and processing, which stores a single copy of the raster data and without performing an expensive tiling procedure, and thus achieves significant improvement in the storage and updating efficiency. To enable efficient query and batch task processing, Ganos Aero implements an on-the-fly tile production mechanism, and optimizes its performance using the cloud features including decoupling compute from storage and pushing costly operations closer to the storage layer.
Since deployed in Alibaba Cloud in 2022, Ganos Aero has been playing a critical role in many real applications including the modern agriculture, environment monitoring and protection, et al.
RESCU-SQL: Oblivious Querying for the Zero Trust Cloud
Authors: Li Xiling , Tan Gefei , Wang Xiao , Rogers Jennie , Homsi Soamar 
Published: September 2023

Cloud service providers offer robust infrastructure for rent to organizations of all kinds. High stakes applications, such as the ones in defense and healthcare, are turning to the public cloud for a cost-effective, geographically distributed, always available solution to their hosting needs. Many such users are unwilling or unable to delegate their data to this third-party infrastructure.
In this demonstration, we introduce RESCU-SQL, a zero-trust platform for resilient and secure SQL querying outsourced to one or more cloud service providers. RESCU-SQL users can query their DBMS using cloud infrastructure alone without revealing their private records to anyone. It does so by executing the query over secure multiparty computation. We call this system zero trust because it can tolerate any number of malicious servers provided one of them remains honest. Our demo will offer an interactive dashboard with which attendees can observe the performance of RESCU-SQL deployed on several in-cloud nodes for the TPC-H benchmark. Attendees can select a computing party and inject messages from it to explore how quickly it detects and reacts to a malicious party. This is the first SQL system to support all-but-one maliciously secure querying over a semi-honest coordinator for efficiency.
Demonstrating GPT-DB: Generating Query-Specific and Customizable Code for SQL Processing with GPT-4
Authors: Trummer Immanuel 
Published: September 2023

GPT-DB generates code for SQL processing in general-purpose programming languages such as Python. Generated code can be freely customized using user-provided natural language instructions. This enables users, for instance, to try out specific libraries for SQL processing or to generate non-standard output while processing.
GPT-DB is based on OpenAI's GPT model series, neural networks capable of translating natural language instructions into code. By default, GPT-DB exploits the most recently released GPT-4 model whereas visitors may also select prior versions for comparison. GPT-DB automatically generates query-specific prompts, instructing GPT on code generation. These prompts include a description of the target database, as well as logical query plans described as natural language text, and instructions for customization. GPT-DB automatically verifies, and possibly re-generates, code using a reference database system for result comparisons. It enables users to select code samples for training, thereby increasing accuracy for future queries. The proposed demonstration showcases code generation for various queries and with varying instructions for code customization.
The Story of GraphLab - From Scaling Machine Learning to Shaping Graph Systems Research (VLDB 2023 Test-of-Time Award Talk)
Authors: Gonzalez Joseph E. , Low Yucheng 
Published: September 2023

The GraphLab project spanned almost a decade and had profound academic and industrial impact on large-scale machine learning and graph processing systems. There were numerous papers written describing the innovations in GraphLab including the original vertex-centric [8] and edge-centric [3] programming abstractions, high-performance asynchronous execution engines [9], out-of-core graph computation [6], tabular graph-systems [4], and even new statistical inference algorithms [2] enabled by the GraphLab project. This work became the basis of multiple PhD theses [1, 5, 7]. The GraphLab open-source project had broad academic and industrial adoption and ultimately lead to the launch of Turi.
In this talk, we tell the story of GraphLab, how it began and the key ideas behind it. We will focus on the approach to achieving scalable asynchronous systems in machine learning. During our talk, we will explore the impact that GraphLab has had on the development of graph processing systems, graph databases, and AI/ML; Additionally, we will share our insights and opinions into where we see the future of these fields heading. In the process, we highlight some of the lessons we learned and provide guidance for future students.