bluuebunny/crossref_metadata_2025_split huggingface dataset:
Renewing our commitment to protect children experiencing armed conflict
Authors: Oberg Charles , Goldhagen Jeffrey , Spencer Nicholas 
Published: February 2023

Civilian casualties from armed conflicts have increased, such that 90% of deaths from armed conflicts in the first decade of the 21st century have been civilians, a significant number of whom are children. The acute and chronic effects of armed conflict on child health and well‐being are among the most significant children's rights violations of the 21st century. Children are increasingly exposed to armed conflict and targeted by governmental and non‐governmental combatants. Despite International Human Rights and Humanitarian laws and multiple international declarations, conventions, treaties and courts, injury and death of children due to armed conflicts have worsened over the decades. It is critically important that a concerted effort be undertaken to address and rectify this issue. Toward this end, the Internal Society of Social Pediatrics and Chid Health (ISSOP) and others have called for a renewed commitment to children experiencing armed conflict with an immediate call to implement a new UN Humanitarian Response on Child Casualties in Armed Conflict.
Materiality and Change in Social Fields
Authors: Stoltz Dustin S. , Taylor Marshall A. 
Published: February 2023

AbstractAs field change is often explained by recourse to agentic efforts of a few or revolutionary turbulence of many, this paper provides a complementary explanation of change grounded in the quotidian dynamics of physical objects and settings. Using the culinary and mountaineering fields, we demonstrate how attending to the materiality of objects and settings offers analytical leverage into the ways fields conflict and change. More specifically, we argue field instability is normal because, at the level of social action,massandenergyare inherently finite. As a result, actors responding to effects from distal fields may nevertheless collide over the objects and settings in which they are compelled to act.
Recombination humanized type III collagen promotes oral ulcer healing
Authors: Shuai Xinxing , Kang Ning , Li Yuhan , Bai Mingxuan , Zhou Xinyi , Zhang Yanjun , Lin Weimin , Li Hanwen , Liu Caojie , Lin Hai , Yuan Quan 
Published: February 2023

AbstractObjectiveRecombinant humanized type III collagen (rhCol III) is a highly adhesive biomaterial composed of 16 adhesion‐related tandem repeats refined from human type III collagen. Here, we aimed to investigate the effect of rhCol III on oral ulcers and reveal the underlying mechanism.MethodsAcid‐induced oral ulcers were induced on the murine tongue, and rhCol III or saline drops were administered. The effect of rhCol III on oral ulcers was assessed using gross and histological analyses. The effects on the proliferation, migration, and adhesion of human oral keratinocytes were investigated in vitro. The underlying mechanism was explored using RNA sequencing.ResultsAdministration of rhCol III accelerated the lesion closure of oral ulcers, reduced the release of inflammatory factors, and alleviated pain. rhCol III promoted the proliferation, migration, and adhesion of human oral keratinocytes in vitro. Mechanistically, the enrichment of genes associated with the Notch signaling pathway was upregulated after rhCol III treatment.ConclusionrhCol III promoted the healing of oral ulcers, showing promising therapeutic potential in oral clinics.
Effects of Adding Morphine to Periarticular Infiltration Analgesia Combined with Single Dose Epidural Morphine in Total Knee Arthroplasty: A Randomized Controlled Study
Authors: Li Yicheng , Wulamu Wuhuzi , Yushan Nuerailijiang , Guo Xiaobin , Gu Wenchao , Cao Li , Zhang Xiaogang 
Published: February 2023

ObjectiveMorphine plays an important role in postoperative analgesia after total knee arthroplasty (TKA). However, there are limited data that investigate the administration ways of morphine. To evaluate the efficacy and safety of adding morphine to periarticular infiltration analgesia (PIA) combined with single‐dose epidural morphine for the patients undergoing TKA.MethodsIn total, 120 patients with knee osteoarthritis who underwent the primary TKA from April 2021 and March 2022 were randomized into three groups (a cocktail containing morphine with single‐dose epidural morphine [Group A]; a cocktail containing morphine [Group B]; and a cocktail free of morphine [Group C]). The three groups were compared based on the Visual Analog Score at rest and during motion, requirement of tramadol, functional recovery including quadriceps strength and range of motion, and adverse events including nausea and vomiting and local and systemic adverse events. The repetitive measure analysis of variance and chi‐square test among three groups were used to analyze the results.ResultsAnalgesia strategy in Group A (0.4 ± 0.8, and 0.9 ± 1.0 points, respectively) significantly reduced rest pain at 6 and 12 h after surgery relative to Group B (1.6 ± 1.2, and 2.2 ± 1.4 points, respectively) (p < 0.001), and the analgesic effect of Group B was stronger than that of Group C (2.1 ± 0.9, and 2.6 ± 0.9 points, respectively) (p < 0.05). Rest pain at 24 h after surgery was significantly lower in Group A (2.5 ± 0.8 points) and B (1.9 ± 1.0 points) than in Group C (2.5 ± 0.8) (p < 0.05). Within 24 h after surgery, the requirements for tramadol in Group A (0.25 g) and Group B (0.35 g) were significantly lower than those in Group C (0.75 g) (p < 0.05). Within 4 days of surgery, the quadriceps strength in the three groups increased gradually, and no statistical significance was noted among the three groups (p > 0.05). From the second day to the fourth day after surgery, although the three groups showed no statistical difference in the range of motion, the result of Group C was inferior to that of the other two groups. There were no significant differences in the incidence of postoperative nausea and vomiting and metoclopramide consumption among the three groups (p > 0.05).ConclusionPIA combined with single‐dose epidural morphine effectively reduces early postoperative pain and tramadol requirement as well as few complications, which can become a safe and effective measure to improve postoperative pain after TKA.
HSP90.2 promotes CO2 assimilation rate, grain weight and yield in wheat
Authors: Yan Yan , Wang Meng‐Lu , Guo Yue‐Ting , Ding Ci‐Hang , Niu Ke‐Xin , Li Xiao‐Ming , Sun Congwei , Dong Zhongdong , Cui Dangqun , Rasheed Awais , Hao Chenyang , Zhang Xueyong , Guo Ganggang , Ni Zhongfu , Sun Qixin , Chen Feng , Gou(缑金营) Jin‐Ying 
Published: February 2023

SummaryWheat fixes CO2 by photosynthesis into kernels to nourish humankind. Improving the photosynthesis rate is a major driving force in assimilating atmospheric CO2 and guaranteeing food supply for human beings. Strategies for achieving the above goal need to be improved. Here, we report the cloning and mechanism of CO2 ASSIMILATION RATE AND KERNEL‐ENHANCED 1 (CAKE1) from durum wheat (Triticum turgidum L. var. durum). The cake1 mutant displayed a lower photosynthesis rate with smaller grains. Genetic studies identified CAKE1 as HSP90.2‐B, encoding cytosolic molecular chaperone folding nascent preproteins. The disturbance of HSP90.2 decreased leaf photosynthesis rate, kernel weight (KW) and yield. Nevertheless, HSP90.2 over‐expression increased KW. HSP90.2 recruited and was essential for the chloroplast localization of nuclear‐encoded photosynthesis units, for example PsbO. Actin microfilaments docked on the chloroplast surface interacted with HSP90.2 as a subcellular track towards chloroplasts. A natural variation in the hexaploid wheat HSP90.2‐B promoter increased its transcription activity, enhanced photosynthesis rate and improved KW and yield. Our study illustrated an HSP90.2–Actin complex sorting client preproteins towards chloroplasts to promote CO2 assimilation and crop production. The beneficial haplotype of Hsp90.2 is rare in modern varieties and could be an excellent molecular switch promoting photosynthesis rate to increase yield in future elite wheat varieties.
Xylem resistance to cavitation increases during summer in Pinus halepensis
Authors: Feng Feng , Wagner Yael , Klein Tamir , Hochberg Uri 
Published: February 2023

AbstractCavitation resistance has often been viewed as a relatively static trait, especially for stems of forest trees. Meanwhile, other hydraulic traits, such as turgor loss point (Ψtlp) and xylem anatomy, change during the season. In this study, we hypothesized that cavitation resistance is also dynamic, changing in coordination with Ψtlp. We began with a comparison of optical vulnerability (OV), microcomputed tomography (µCT) and cavitron methods. All three methods significantly differed in the slope of the curve,Ψ12 and Ψ88, but not in Ψ50 (xylem pressures that cause 12%, 88%, 50% cavitation, respectively). Thus, we followed the seasonal dynamics (across 2 years) of Ψ50 in Pinus halepensis under Mediterranean climate using the OV method. We found that Ψ50 is a plastic trait with a reduction of approximately 1 MPa from the end of the wet season to the end of the dry season, in coordination with the dynamics of the midday xylem water potential (Ψmidday) and the Ψtlp. The observed plasticity enabled the trees to maintain a stable positive hydraulic safety margin and avoid cavitation during the long dry season. Seasonal plasticity is vital for understanding the actual risk of cavitation to plants and for modeling species' ability to tolerate harsh environments.
Abyssal geography†
Authors: Chandler David , Pugh Jonathan 
Published: February 2023

Today, we are held to live in the Anthropocene, bringing to an end modern binary imaginaries, such as the separation between Human and Nature, and with them Western assumptions of progress, linear causality and human exceptionalism. Much Western critical theory, from new or vital materialism to post‐ and more‐than‐human thinking, unsurprisingly reflects this internal crisis of faith in Eurocentric or Enlightenment reasoning. At the same time, a radically different critique of modernity has gained prominence in recent years, emerging from critical Black studies, which places the Caribbean at the centre of the development of a new and distinct mode of critical thought. In attempting to grasp the ways in which Caribbean thought and practice have been seen to enable a distinctive alternative non‐Eurocentric imaginary, this paper heuristically sets out a paradigmatic framing of ‘abyssal geography’. We emphasize two key points. The first is that abyssal thought is not grounded in abstract and timeless philosophical assumptions but figuratively draws upon aspects of Caribbean practices of resistance and survival, for example, from the Middle Passage, Plantation, carnival, creolization, dance forms and speculative fiction. The second is that abyssal work engages the legacies of modernity and coloniality by explicitly seeking to question the lure of ontology: seeking to disrupt, suspend and to problematize the modern project of the human and the world.
Moral intuitions and vaccine hesitancy during the COVID‐19 pandemic
Authors: Iceland John , Silver Eric , Goff Kerby 
Published: February 2023

AbstractBackgroundWhile the COVID‐19 pandemic has resulted in millions of deaths worldwide, the rapid development and distribution of novel vaccines reduced the scale of severe illness and death. Even so, many people remain unvaccinated.ObjectiveWe investigate the extent to which various moral intuitions are associated with COVID‐19 vaccine hesitancy.MethodsWe use data from a 2021 national YouGov sample of U.S. adults and logistic regression to examine the association between moral intuitions, net of other factors, and getting vaccinated for COVID‐19.ResultsIndividualizing moral intuitions, which emphasize care and fairness, are positively associated with the likelihood of getting vaccinated. We also find that binding moral intuitions—which emphasize loyalty, respect for authority, and sanctity of the human body—are negatively associated with getting vaccinated and that this association is driven largely by sanctity. Finally, those whose moral intuitions emphasize liberty are significantly less likely to get vaccinated.ConclusionMoral intuitions are strongly associated with vaccine hesitancy, suggesting that the success of public health measures during a global health crisis depends on addressing the variety of underlying moral concerns that influence people's attitudes and behaviors.
Economic ideas and Taiwan's shift to export promotion in the 1950s
Authors: Irwin Douglas A. 
Published: February 2023

AbstractTaiwan was the first developing country to adopt an export‐oriented trade strategy after World War II. The factors usually associated with big shifts in policy—a macroeconomic crisis, a change in political power or institutions, lobbying by export interests, pressure from international financial institutions—were not present; it was ideas that were key. In 1954, economist S. C. Tsiang proposed that Taiwan boost export earnings rather than squeeze import spending to deal with its chronic shortage of foreign exchange. He recommended a currency devaluation to establish a realistic exchange rate and a market‐based system of foreign exchange allocation to end the inefficient rationing by the government. Four years later, a policymaker, K. Y. Yin, fought for the adoption of Tsiang's proposal, helping to clear the way for Taiwan's phenomenal growth in trade.
International trade, intellectual property rights and the (un)employment of migrants
Authors: Guichard Lucas , Stepanok Ignat 
Published: February 2023

AbstractWe study the effect of trade liberalisation and intellectual property rights (IPR) protection on the unemployment rate of migrants relative to nonmigrants. We build a North–South trade and growth model with a positive steady state rate of migration. We find that bilateral trade liberalisation decreases the relative unemployment rate of migrants when migration is low and increases the relative unemployment rate when the migration rate is high. The results do not rely on assumptions about network effects, the probability to find a job for a migrant is independent of the relative size of the migrant diaspora. IPR protection leads to a higher relative unemployment rate of migrants regardless of the size of migration. We provide suggestive empirical evidence in line with the theoretical predictions on trade liberalisation and IPR protection using data for 20 OECD countries over the period 2000–2014.
Part Change Management: A Case Study on Automotive Engineering and Production; Domestic and International Perspectives
Authors: Knackstedt Stephan , Sutton Meredith , Summers Joshua D. 
Published: February 2023

AbstractDue to interest in aspects such as process, strategies, and tools of engineering changes expressed in a literature review, a case study was done on a major automotive original equipment manufacturer (OEM) to assess the perceived quality of its part engineering change management process and supporting system through its employees’ eyes. A combination of 12 interviews lasting 12 h and 46 written surveys was used to capture the views of participants from all major functions found at the research and development (R&D) headquarters of the OEM: Purchasing, Production, Development, and one group consisting of all other functions (“Other”). Statistical analysis was performed to identify statistically significant differences between employee perceptions of an engineering change management system among different departments, amount of use, and years of use. It was found that statistically significant differences exist in terms of understanding the usability of the system between different departments and also between different years of experience.
Hyperbolicity, Mach Lines, and Super-Shear Mode III Steady-State Fracture in Magneto-Flexoelectric Materials, Part II: Crack-Tip Asymptotics
Authors: Giannakopoulos A.E. , Knisovitis Ch. , Zisis Th. , Rosakis Ares J. 
Published: February 2023

AbstractIn our previous study (Part I), the anti-plane steady-state hyperbolic mode III fracture of a magneto-flexoelectric material was solved for the displacement, the polarization, and the magnetic fields. The solution, however, was based on the assumption of the development of strain discontinuities, and the propagation of the crack-tip was related to a critical shear strain. However, in the current study, the asymptotic details of the fields close to the crack-tip were investigated. The asymptotic analysis assumes strain continuity at the crack-tip (discontinuity in the strain gradients) and reveals the existence of a positive dynamic J-integral. The asymptotic analysis was performed not only for hyperbolic but also for elliptic conditions, and the energy release rate was calculated as a function of the crack-tip velocity in both regimes. These results are very different from those predicted by classical singular elastodynamics, where the dynamic J-integral is zero when super-shear is attained and there can be only an elliptic solution. Moreover, the results are very useful for couple-stress elastodynamics where equivalent length scales are present due to the analogy with flexoelectricity.
Dynein Dysfunction Prevents Maintenance of High Concentrations of Slow Axonal Transport Cargos at the Axon Terminal: A Computational Study
Authors: Kuznetsov Ivan A. , Kuznetsov Andrey V. 
Published: February 2023

AbstractHere, we report computational studies of bidirectional transport in an axon, specifically focusing on predictions when the retrograde motor becomes dysfunctional. We are motivated by reports that mutations in dynein-encoding genes can cause diseases associated with peripheral motor and sensory neurons, such as type 2O Charcot-Marie-Tooth disease. We use two different models to simulate bidirectional transport in an axon: an anterograde-retrograde model, which neglects passive transport by diffusion in the cytosol, and a full slow transport model, which includes passive transport by diffusion in the cytosol. As dynein is a retrograde motor, its dysfunction should not directly influence anterograde transport. However, our modeling results unexpectedly predict that slow axonal transport fails to transport cargos against their concentration gradient without dynein. The reason is the lack of a physical mechanism for the reverse information flow from the axon terminal, which is required so that the cargo concentration at the terminal could influence the cargo concentration distribution in the axon. Mathematically speaking, to achieve a prescribed concentration at the terminal, equations governing cargo transport must allow for the imposition of a boundary condition postulating the cargo concentration at the terminal. Perturbation analysis for the case when the retrograde motor velocity becomes close to zero predicts uniform cargo distributions along the axon. The obtained results explain why slow axonal transport must be bidirectional to allow for the maintenance of concentration gradients along the axon length. Our result is limited to small cargo diffusivity, which is a reasonable assumption for many slow axonal transport cargos (such as cytosolic and cytoskeletal proteins, neurofilaments, actin, and microtubules) which are transported as large multiprotein complexes or polymers.
Impact of Thermal-Hydraulic Feedback and Differential Thermal Expansion on European Sodium-Cooled Fast Reactor Core Power Distribution
Authors: Lindley Ben , Álvarez Velarde Francisco , Baker Una , Bodi Janos , Cosgrove Paul , Charles Alan , Fiorina Carlo , Fridman Emil , Krepel Jiri , Lavarenne Jean , Mikityuk Konstantin , Nikitin Evgeny , Ponomarev Alexander , Radman Stefan , Shwageraus Eugene , Tollit Brendan 
Published: February 2023

AbstractThe objective of this paper is to quantify the coupling effect on the power distribution of sodium-cooled fast reactors (SFRs), specifically the European SFR. Calculations are performed with several state-of-the-art reactor physics and Multiphysics codes (TRACE/PARCS, DYN3D, WIMS, COUNTHER, and GeN-Foam) to build confidence in the methodologies and validity of results. Standalone neutronic calculations were generally in excellent agreement with a reference Monte Carlo-calculated power distribution (from Serpent). Next, the impact of coolant density and fuel temperature Doppler feedback was calculated. Reactivity coefficients for perturbations in the inlet temperature, coolant heat up and core power was shown to be negative with values of around −0.5 pcm/°C, −0.3 pcm/°C, and −3.5 pcm/%, respectively. Fuel temperature and coolant density feedback was found to introduce a roughly −1%/+1% in/out power tilt across the core. Calculations were then extended to axial expansion for cases where fuel is linked and unlinked to the clad. Core calculations are in good agreement with each other. The impact of differential fuel expansion is found to be larger for fuel both linked and unlinked to the clad, with the in/out power tilt increasing to around −4%/+2%. Thus, while broadly confirming the known result that standalone physics calculations give good results, the expansion coupling effect is perhaps more than anticipated a priori. These results provide a useful benchmark for the further development of Multiphysics codes and methodologies in support of advanced reactor calculations.
Dynamic Stress Analysis of Multisegment Curved Pipes Subjected to the Passage of an In-Line Inspection Tool
Authors: Mostaghimi Hamid , Rezvani Sina , Chune Ronald , Hugo Ron , Park Simon 
Published: February 2023

AbstractPipelines are susceptible to degradation over time due to different types of defects caused by environmental and loading conditions. In-line inspection (ILI) is a preventive examination method widely used to monitor the degradation of pipelines. The passage of an ILI tool through a segment of a pipeline with loose boundary condition can generate significant dynamic stress within the pipe. When pipelines pass through excavated sites, bridges, water, and bog, or have free-span segments, they are at a greater risk of dynamic stress. This research aims to study the effects of passing an ILI tool through pipelines consisting of straight and curved segments. A three-dimensionial finite element (FE) model based on the Timoshenko beam theory is developed to model the vibration response of curved pipes during the passage of an ILI tool. Lab-scale experiments are performed to verify the simulation results of the developed FE model. The developed model is further verified through the FE analysis performed in abaqus™ implicit. A comparison of the simulation and experimental results shows that the proposed FE model effectively and accurately predicts the dynamic stress and dynamic displacements of multisegment pipes during the passage of an ILI tool.