bluuebunny/crossref_metadata_2025_split huggingface dataset:
Concomitant deletion of the short arm (del(1p13.3)) and amplification or gain (1q21) of chromosome 1 by fluorescence in situ hybridization are associated with a poor clinical outcome in multiple myeloma
Authors: Mohan Meera , Gong Zimu , Ashby Timothy Cody , Al Hadidi Samer , Thanendrarajan Sharmilan , Schinke Carolina , Alapat Daisy , Shaughnessy John D. , Zhan Fenghuang , van Rhee Frits , Sawyer Jeffery R. , Tian Erming , Zangari Maurizio 
Published: June 2023

AbstractBackgroundChromosome 1 abnormalities in multiple myeloma (MM) are increasingly recognized as high risk‐defining features. The authors report the prognostic value of del(1p13.3) by fluorescence in situ hybridization (FISH) at enrollment in subjects treated on total therapy clinical trials 2–6.MethodsFISH probes were generated from specific BAC DNA clones for the AHCYL1 gene locus (1p13.3) and the CKS1B locus (1q21).ResultsA total of 1133 patients were included in this analysis. Although del(1p13.3) was detected in 220 (19.4%) patients, 1q21gain or 1q21amp were observed in 300 (26.5%) and 150 (13.2%) patients, respectively. Concomitant del(1p13.3) with 1q21 gain or amp was observed in 65 (5.7%) and 29 (2.5%) patients, respectively. There was enrichment of high‐risk features such as International Staging System (ISS) stage 3 disease and gene expression profiling (GEP)70 high risk (HR) in the group with del(1p13.3). Presence of del(1p13.3) confers inferior progression‐free survival (PFS) and overall survival (OS). On multivariate analysis, the presence of ISS stage 3 disease, GEP70 HR, 1q21gain, and 1q21amp were independent predictors of PFS or OS.ConclusionsThe PFS and OS of patients with combined abnormalities of del (1p13.3)/1q21gain or amp was significantly worse compared to del(1p13.3) alone and 1q21gain or 1q21 amp alone, which identifies a subset of patients with poor clinical outcomes.
Solar Efficiency of Azo‐Photoswitches for Energy Conversion: A Comprehensive Assessment
Authors: Sun Wenjin , Shangguan Zhichun , Zhang Xu , Dang Tongtong , Zhang Zhao‐Yang , Li Tao 
Published: June 2023

AbstractPhotoswitches can absorb solar photons and store them as chemical energy by photoisomerization, which is regarded as a promising strategy for photochemical solar energy storage. Although many efforts have been devoted to photoswitch discovery, the solar efficiency, a critical fundamental parameter assessing the solar energy conversion ability, has attracted little attention and remains to be studied comprehensively. Here we provide a systematic evaluation of the solar efficiency of typical azo‐switches including azobenzenes and azopyrazoles, and gain a comprehensive understanding on its decisive factors. All the efficiencies are found below 1.0 %, far from the proposed limits for molecular solar thermal energy storage systems. Azopyrazoles exhibit remarkably higher solar efficiencies (0.59–0.94 %) than azobenzenes (0.11–0.43 %), benefiting from largely improved quantum yield and photoisomerization yield. Light filters can be used to improve the isomerization yield but inevitably narrow the usable range of solar spectrum, and these two contradictory effects ultimately reduce solar efficiencies. We envision this conflict could be resolved through developing azo‐switches that afford high isomerization yields by absorbing wide‐spectrum solar energy. We hope this work could promote more efforts to improve the solar efficiency of photoswitches, which is highly relevant to the prospect for future applications.
Conditions for realization of multiple pinch‐off points in generalized fractional‐order memory elements
Authors: Oresanya Babajide Oluwatosin , Si Gangquan , Xu Xiang , Gong Jiahui , Guo Zhang 
Published: June 2023

SummaryMemelements (memristor, meminductor, and memcapacitor) have gained wide interests due to their useful hysteresis and nonlinear properties. In this work, fractional‐order current‐controlled memelements are modeled using an
‐order polynomial. By decomposing the
‐order polynomial into some
sets of current‐controlled functions, we were able to theoretically analyze and establish the general conditions necessary for all memelements' voltage‐current dynamics to create up to
number of lobes and hence
pinch‐off points in their
hysteresis. The exact coordinate locations of the pinch‐off points on the
‐axis and
‐axis are calculated in all cases. The observations made in this work are novel and contributes to how all multiple‐lobed memory elements are analyzed. A general emulator circuit is then designed to verify the theoretical deductions, the emulator output agrees with the numerical results.
Bilateral localized primary parotid gland amyloidosis: A rare entity with literature review
Authors: Abdelwahed Mohammed , Kawam Alae , Gimenez Cecilia , Rosca Oana C. 
Published: June 2023

AbstractAmyloidosis of the salivary glands is a rare occurrence. Due to non‐specific clinical presentation, the diagnosis can be overlooked. Here we present a case of a localized bilateral parotid glands AL kappa‐light chain amyloid deposition without systemic involvement, as well as a literature review. Fine needle aspiration (FNA) of a right parotid lesion was performed with rapid on‐site evaluation (ROSE). Slides showed characteristic amyloid staining with Congo red and typical Apple‐green birefringence under polarized light microscopy. Amyloid in the head and neck can be misinterpreted as other materials such as colloid, keratin, necrosis, hyaline degeneration especially when the condition is not suspected.
Long‐term marine protection enhances kelp forest ecosystem stability
Authors: Peleg Ohad , Blain Caitlin O. , Shears Nick T. 
Published: June 2023

AbstractTrophic downgrading destabilizes ecosystems and can drive large‐scale shifts in ecosystem state. While restoring predatory interactions in marine reserves can reverse anthropogenic‐driven shifts, empirical evidence of increased ecosystem stability and persistence in the presence of predators is scant. We compared temporal variation in rocky reef ecosystem state in New Zealand's oldest marine reserve to nearby fished reefs to examine whether protection of predators led to more persistent and stable reef ecosystem states in the marine reserve. Contrasting ecosystem states were found between reserve and fished sites, and this persisted over the 22‐year study period. Fished sites were predominantly urchin barrens but occasionally fluctuated to short‐lived turfs and mixed algal forests, while reserve sites displayed unidirectional successional trajectories toward stable kelp forests (Ecklonia radiata) taking up to three decades following protection. This provides empirical evidence that long‐term protection of predators facilitates kelp forest recovery, resists shifts to denuded alternate states, and enhances kelp forest stability.
One body, two faces: How double standards influence body evaluation in women with binge‐eating disorder compared to mentally healthy women with higher weight and average weight
Authors: Quittkat Hannah L. , Voges Mona M. , Kisker Joanna , Schöne Benjamin , Düsing Rainer , Vocks Silja 
Published: June 2023

AbstractObjectiveResearch has found evidence that women with anorexia nervosa (AN) and bulimia nervosa (BN) apply different standards for themselves than for others when evaluating bodies, an aspect of a disturbed body image. This study investigates whether women with binge‐eating disorder (BED) likewise show self‐deprecating double standards (DS).MethodsWomen with BED (n = 40), women with higher weight (n = 40) and women with average weight (n = 40) viewed a presentation of different builds, including their individual ideal body, which were presented once with participants' own and once with an unknown woman's face. After each presentation, participants rated their emotional response regarding arousal and valence, and evaluated the body's attractiveness, body fat and muscle mass. DS were defined as the difference in ratings of the same body with one's own and the unknown face.ResultsWomen with BED showed a higher degree of negative emotions in response to a thin and a high‐weight build, rated lower levels of body attractiveness for an athletic build, and displayed more arousal for almost all builds presented with their own compared to with another face. While women with BED showed a higher burden on measures of eating pathology and body image than the other groups, DS were not more pronounced in women with BED.DiscussionThe findings contradict DS as a characteristic feature of BED, but underline “normative” DS for higher‐weight/high‐weight builds, reflecting weight stigmatization. Psychoeducation on these DS might complement cognitive‐behavioral therapy in BED in order to reduce negative emotions.Public significanceA bias in body evaluation has been proven in women with anorexia and BN, but no research has examined this in women with BED. This study provides evidence of DS in body evaluation in women with BED, compares the extent of DS between women with BED, higher weight, and average weight, and investigates individual body ideals in women with BED and higher weight.
Parental self‐efficacy: Longitudinal impact on clinical outcomes across levels of care in adolescent anorexia nervosa
Authors: Gorrell Sasha , Downey Amanda E. , Saunders Elizabeth , Accurso Erin C. , Buckelew Sara , Kreiter Anna , Le Grange Daniel , Garber Andrea K. 
Published: June 2023

AbstractObjectiveParental self‐efficacy in the domain of weight restoration for adolescents with restrictive eating disorders is central to success in family‐based interventions. We sought to characterize this parental self‐efficacy during a brief hospitalization for medical stabilization and follow‐up among patients with anorexia nervosa (AN) or atypical AN (AAN) enrolled in the StRONG clinical trial to understand the potential impact of inpatient treatment on caregiver empowerment.MethodsPatients were enrolled upon hospital admission and refed per protocol. We examined correlates of the Parents Versus Anorexia (PVA) scale, a measure of parental self‐efficacy in the domain of weight restoration, at admission, discharge, 10‐days, 1‐month, and 3‐months post‐discharge. Multi‐level models evaluated associations among PVA scores and change in %median BMI and Eating Disorder Examination‐Questionnaire (EDE‐Q) global scores over 3‐months post‐discharge.ResultsParents of N = 67 adolescents and young adults M(SD) age 15.79 (2.20) years and 85.00 (11.86) %median BMI participated. PVA scores did not change significantly during hospitalization (p = .053), which lasted on average 10.7 ± 4.5 days. PVA scores increased post‐discharge (p = .009), with significant increase between discharge and 1‐month post‐discharge (p = .045). PVA scores were not associated with subsequent clinical outcomes. Rather, a main effect of time significantly predicted higher %median BMI and improved EDE‐Q scores (p < .001).DiscussionThe finding that parental self‐efficacy did not deteriorate during the inpatient stay is promising given the medical necessity of hospitalization to ensure short‐term safety in some cases and the importance of parental self‐efficacy to support long‐term recovery.Public significanceFamily‐based treatment is the recommended treatment for young people with AN and AAN, serious psychiatric illnesses that may require inpatient medical stabilization. Prior evidence suggests that parental self‐efficacy in the outpatient setting is a key component of treatment success. The current study suggests that parental self‐efficacy and longer‐term treatment outcomes are not undermined by a brief inpatient hospitalization.
Climate‐driven decline in the habitat of the endemic spiny babbler (Turdoides nipalensis)
Authors: Adhikari Binaya , Subedi Suresh C. , Bhandari Shivish , Baral Kedar , Lamichhane Sandesh , Maraseni Tek 
Published: June 2023

AbstractClimate change could amplify the extinction risk of endemic species, and the risk is even greater for species occupying high elevations and mountain ranges. In this study, we assessed the climatically suitable habitat of the only endemic Nepalese bird species, the spiny babbler (Turdoides nipalensis), and predicted the extent of the future (2050 and 2070) habitat of this species under two climate change scenarios (SSP2‐4.5 and SSP5‐8.5). We used georeferenced occurrence points alongside ecologically meaningful climatic and topographic variables to develop an ensemble suitable habitat model using different species distribution modeling algorithms in BIOMOD2. We identified 22,488.83 km2 (15%) of Nepal's total land area as suitable habitat for this endemic species, where the nonprotected regions incorporated the largest extent of suitable habitat (88%), with a majority of this suitable area within the central Mid‐Hill region. Under the SSP2‐4.5 scenario, 21.58% and 34.08% of the current suitable habitat range are projected to be lost by 2050 and 2070, respectively. Whereas under the SSP5‐8.5 scenario, our projections suggest that 40.45% and 52.18% of habitat will be lost by 2050 and 2070, respectively. Habitat suitability increased with a rise in warmest quarter precipitation (above 1000 mm), coldest quarter precipitation between 50 and 100 mm, and warmest quarter temperature between 20 and 30°C. Given our results, it is crucial to review the conservation policy of nonprotected areas and formulate a spiny babbler‐specific conservation action plan with a special focus on protecting their primary habitat in human‐dominated landscapes and nonprotected areas.
Fast short‐circuit protection under current imbalance condition for multi‐paralleled SiC‐MOSFETs
Authors: Suzuki Hiroshi , Funaki Tsuyoshi 
Published: June 2023

AbstractThis paper proposes methodology and gate drive circuit that can immediately detect short‐circuit (SC) of multiparalleled SiC‐MOSFETs even under current imbalance condition. Proposed method detects SC current using an integration circuit that can sense di/dt. The detection level of SC current can be adjusted to a desired value regardless of the number of SiC‐MOSFETs connected in parallel. The effectiveness of the proposed approach was experimentally validated for four‐paralleled SiC‐MOSFETs under extreme current imbalance in SC condition. SC was detected within 0.5 μs and all SiC‐MOSFETs were protected without destruction at most 2.2 μs after the onset of SC, for all types of SC 1, 2, and 3.
Basic study on calibration using waveform variation in space charge measurement by pulsed electroacoustic method
Authors: Li Xiaoxin , Kawashima Tomohiro , Murakami Yoshinobu , Hozumi Naohiro 
Published: June 2023

AbstractThe pulsed electroacoustic method determines the distribution of space charge in an insulation system by applying a pulse voltage and detecting the acoustic response. It estimates the location and magnitude of charges from time‐domain signals. For quantitative analysis, a bias voltage is applied to a specimen with no space charge, and the acoustic signal generated from the electrodes only is used as a reference waveform for calibration. However, a full‐scale, extra‐high voltage insulation system often already contains space charges in it. Therefore, a method of acquiring a reference signal under such a condition was studied. We studied methods to compare voltage variations and response signal variations. We proposed a method that measures the signal difference at different voltages. In addition, we proposed a method of correlating voltage and signal variations that may allo for more rapid signal acquisition. The feasibility was proved using an 11 mm‐thick mimic polyethylene specimen.
Liver tests, cardiovascular outcomes and effects of empagliflozin in patients with heart failure and preserved ejection fraction: The EMPEROR‐Preserved trial
Authors: Böhm Michael , Butler Javed , Krawczyk Marcin , Mahfoud Felix , Haring Bernhard , Filippatos Gerasimos , Ferreira João Pedro , Pocock Stuart J. , Brueckmann Martina , Ofstad Anne Pernille , Schüler Elke , Wanner Christoph , Verma Subodh , Packer Milton , Anker Stefan D. ,   the EMPEROR‐Preserved Trial Committees and Investigators
Published: June 2023

AimThe prognostic implication of elevated liver tests in heart failure with preserved ejection fraction (HFpEF) is uncertain. This analysis investigates the association of liver markers with hospitalization for heart failure (HHF) and cardiovascular death (CVD), and the treatment effect of empagliflozin across the range of liver marker levels.Methods and resultsThe double‐blind, placebo‐controlled EMPEROR‐Preserved (EMPagliflozin outcomE tRial in Patients With chrOnic heaRt Failure with Preserved Ejection Fraction) enrolled 5988 patients with HFpEF (ejection fraction >40%). Patients in New York Heart Association class II–IV and elevated N‐terminal pro‐B‐type natriuretic peptide were randomized to receive empagliflozin 10 mg daily or placebo in addition to usual therapy. Patients with significant liver disease were excluded. The primary endpoint was time to first adjudicated HHF or CVD. We explored the association of liver function abnormalities with heart failure outcomes in patients on placebo, the effects of empagliflozin on liver tests and the treatment effects of empagliflozin on heart failure outcomes across categories of liver laboratory values. High alkaline phosphatase (p trend < 0.0001), low albumin (p trend < 0.0001) and high bilirubin (p = 0.02) were associated with poorer outcomes for HHF or CVD, while high aspartate aminotransferase was not, and high alanine aminotransferase was associated with better outcomes. Empagliflozin had no significant effects on liver tests compared to placebo except for albumin which was significantly increased. The treatment effect of empagliflozin on outcomes was not modified by liver tests.ConclusionAbnormalities of liver function tests are associated differently with heart failure outcomes. Salutary effects of empagliflozin on liver tests were not observed although albumin increased. The treatment benefits of empagliflozin were not affected by baseline values of liver parameters.
Trajectories of renal biomarkers and new‐onset heart failure in the general population: Findings from the PREVEND study
Authors: Sakaniwa Ryoto , Tromp Jasper , Streng Koen W. , Suthahar Navin , Kieneker Lyanne M. , Postmus Douwe , Iso Hiroyasu , Gansevoort Ron T. , Bakker Stephan J.L. , Hillege Hans L. , de Boer Rudolf A. , Demissei Biniyam G. 
Published: June 2023

AimsRenal dysfunction is one of the most critical risk factors for developing heart failure (HF). However, the association between repeated measures of renal function and incident HF remains unclear. Therefore, this study investigated the longitudinal trajectories of urinary albumin excretion (UAE) and serum creatinine and their association with new‐onset HF and all‐cause mortality.Methods and resultsUsing group‐based trajectory analysis, we estimated trajectories of UAE and serum creatinine in 6881 participants from the Prevention of Renal and Vascular End‐stage Disease (PREVEND) study and their association with new‐onset HF and all‐cause death during the 11‐years of follow‐up. Most participants had stable low UAE or serum creatinine. Participants with persistently higher UAE or serum creatinine were older, more often men, and more often had comorbidities, such as diabetes, a previous myocardial infarction or dyslipidaemia. Participants with persistently high UAE had a higher risk of new‐onset HF or all‐cause mortality, whereas stable serum creatinine trajectories showed a linear association for new‐onset HF and no association with all‐cause mortality.ConclusionOur population‐based study identified different but often stable longitudinal patterns of UAE and serum creatinine. Patients with persistently worse renal function, such as higher UAE or serum creatinine, were at a higher risk of HF or mortality.
Effect of rice bran crude lecithin blended diet on rumen ecology, metabolic profile, and milk fat indices affecting human health
Authors: Tewari Dharmesh , Chaturvedi V. B. , Dutta Narayan , Chaudhary Sandeep Kr. 
Published: June 2023

AbstractTwo experiments are conducted to find out the effect of rice bran crude lecithin on rumen ecology, milk fat quality, metabolic indices, and leptin (LEP) gene expression. In first experiment, 12 crossbred calves are randomly divided into two groups, that is, RBCL‐0 and RBCL‐6, and they are fed wheat straw based diet with concentrate mixture containing 0% RBCL (CM1) and 6% RBCL (CM2), respectively, for 120 d for rumen fermentation study. Ruminal ammonia‐N and short chain fatty acids and rumen microbes are nonsignificantly affected in RBCL calves. In second experiment, 12 lactating cows are randomly divided into RBCL‐0 and RBCL‐6 groups and fed CM1 and CM2 concentrate along with napier grass as roughage. In milk fatty acid profile, C16:1 fatty acid is significantly lower whilecis‐C18:1 is significantly higher in the RBCL supplemented cows. The atherogenic index and thrombogenic index are 16 and 19% lower while health promoting index, polyunsaturated saturated fatty acids, and hypocholesterolaemic/hypercholesterolaemic are 16, 10, and 16, respectively, higher in RBCL‐6 cows. The mean nonesterified fatty acid and β‐hydroxy butyric acid value is lower while LEP gene expression is higher in RBCL supplemented cows than control cows. The milk income is higher in RBCL cows. Finally, it can be concluded that RBCL at 6% in concentrate mixture of dairy ration do not adversely affect the rumen ecology. Although RBCL has capacity to enhance health properties of milk fat along with profitability, still more studies are warranted.Practical applications: Cow milk has always been an important component of the human diet in the world. The milk composition, especially fat, is directly influenced by feeding regime in dairy animals. In the milk fat, the unsaturated fatty acids (mainly polyunsaturated fatty acids) help in improving the health condition of consumers along with the keeping quality of milk. In this series, rice bran crude lecithin was used in the dairy ration and found that it altered certain metabolic parameters and gene expression, which may be beneficial for animal health without altering rumen fermentation. Although RBCL substantially modify the milk fatty acid profile and improves the fat indices which will enhance the human health by protecting them from cardiovascular diseases.
Enantiomeric analysis of drugs in water samples by using liquid–liquid microextraction and nano‐liquid chromatography
Authors: Salido‐Fortuna Sandra , Bosco Chiara Dal , Gentili Alessandra , Castro‐Puyana María , Marina María Luisa , D'Orazio Giovanni , Fanali Salvatore 
Published: June 2023

AbstractThe nano‐LC technique is increasingly used for both fast studies on enantiomeric analysis and test beds of novel stationary phases due to the small volumes involved and the short conditioning and analysis times. In this study, the enantioseparation of 10 drugs from different families was carried out by nano‐LC, utilizing silica with immobilized amylose tris(3‐chloro‐5‐methylphenylcarbamate) column. The effect on chiral separation caused by the addition of different salts to the mobile phase was evaluated. To simultaneously separate as many enantiomers as possible, the effect of buffer concentration in the mobile phase was studied, and, to increase the sensitivity, a liquid–liquid microextraction based on the use of isoamyl acetate as sustainable extraction solvent was applied to pre‐concentrate four chiral drugs from tap and environmental waters, achieving satisfactory recoveries (>70%).