bluuebunny/crossref_metadata_2025_split huggingface dataset:
Consumer response to wine made from smoke-affected grapes
Authors: Bilogrevic Eleanor , Jiang WenWen , Culbert Julie , Francis Leigh , Herderich Markus , Parker Mango 
Published: June 2023

When vineyards and grapes are exposed to smoke from wildfires or controlled burns, this can result in wines with smoky, burnt or ashy attributes that have been linked to the presence of elevated concentrations of volatile phenols and phenolic glycosides. These smoky flavours are considered undesirable by winemakers, but there is little information about how consumers respond to smoke-affected wines. To investigate whether consumers respond negatively to smoky attributes when wine is tasted blind, three studies assessing sets of Pinot noir rosé, Chardonnay and unoaked Shiraz wines with varied smoke flavour were conducted. Overall, wines rated high in smoke flavour were less liked compared to non-smoke-affected wines. Independent of wine type, there was a strong negative correlation between smoky flavour and overall consumer liking. Detailed data analysis revealed that consumers who are wine drinkers fell into one of three categories: highly responsive to smoke, moderately responsive, or a smaller group of non-responders. This consumer-based information is essential for guiding the assessment of risk from smoke exposure of grapes and potential for quality defects in wine, as well as identifying and benchmarking management options for wine producers, not only in Australia, but globally.
Life Cycle Cost Analysis of Building Maintenance
Authors: Rosita Evita , Yustiarini Dewi , Nurasiyah Siti 
Published: June 2023

<p><em>Building maintenance is an activity to maintain the reliability of the building so that it remains functional following the Regulation of the Minister of Public Works No. 24 / PRT / M / 2008 concerning Building Maintenance Guidelines; building maintenance includes architectural, structural, and mechanical maintenance. This problem must be considered during building construction to realize the use of structures that fulfil requirements for efficiency, environmental harmony, safety, health, comfort, and convenience. With regular maintenance, the building can achieve its design life with a minor frequency of damage and repair. The cost of building maintenance will increase yearly according to the inflation increase in each region. This study aims to analyze the maintenance costs of the Sports Center building using the LCC (Life Cycle Cost) method with architectural aspects (walls, ceilings, and floors) within the next 20 years. Life cycle costs (LCCs) are costs required by a building over the life of its plan. This approach assesses the total cost of an asset over its life cycle, including initial capital costs, maintenance costs, operating costs, and the residual value of an asset at the end of its life. The study's findings demonstrate how to create a model for predicting maintenance costs. According to this, the Sports Center building must spend IDR </em><em>1.445.082.148,15 on maintenance over the next 20 years. The following includes IDR 280.180.770,42 for ceiling maintenance, IDR 338.260.528,79 for walls, and IDR 826.640.848,94 for flooring.</em><em></em></p>
ANTIMICROBIAL EFFECT OF VANCOMYCIN ELECTRO-TRANSFERRED WATER AGAINST METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS VARIANT
Authors: Heredia-Rojas J. Antonio , Villarreal-TreviÃ±o Licet , Rodriguez-de la Fuente Abraham O. , Herrera-Menchaca Laura I. , Gomez-Flores Ricardo , Mata-CÃ¡rdenas Benito David , RodrÃ­guez-Flores Laura E. 
Published: June 2023

Background: There is a number of alternative and complementary therapeutics that are unproven or have not been properly tested. For past twenty years, the transfer of bio-energetic information has been recognized as a novel scientific approach capable of contributing to improved therapy in the management of several diseases through the so-called bio-resonance therapy (BRT). Although BRT was discovered in the late 1980s, it is still poorly studied. The aim of this study was to evaluate the antibacterial effect of water samples transferred with electronic information of vancomycin, a well known drug against methicillin-resistant Staphylococcus aureus (MRSA), by using a BRT device on bacterial cultures.
Material and Methods: MRSA cultures were treated with vancomycin electro-transferred water samples, vancomycin (4.0 and 8.0 µg/mL), sham electro-transferred (water to water) and non-transferred water samples (medium alone). Growth inhibition was evaluated in liquid and solid culture medium, spectrophotometrically and by CFU determination respectively.
Results: The obtained data showed that by transferring vancomycin (4.0 and 8.0 µg/mL) information to water samples, the growth of cultured MRSA was significantly (p< 0.05) inhibited (up to 35%), compared with those cultures treated with electro-transferred water to water or cultured in medium alone (0% growth inhibition).
Conclusion: This in vitro study suggests that water samples that are electronically transferred with vibration sustained information of vancomycin are capable of inhibiting growth of axenically cultured methicillin resistant S. aureus.
COMBINED ADMINISTRATION OF SPONDIAS MOMBIN AND FICUS EXASPERATA LEAF EXTRACTS STALL INDOMETHACIN-MEDIATED GASTRIC MUCOSAL ONSLAUGHT IN RATS.
Authors: Sabiu Saheed , Olarewaju Sulyman Abdulhakeem , Taofeeq Garuba , Olatunde Sunmonu Taofik , Alanamu Abdulrahaman Abdullahi 
Published: June 2023

Background: Despite the rapidly changing concept of gastric ulcer management from conventional vagotomy, H2 receptor antagonists and antacids to proton pump inhibitors, gastrointestinal toxicity remains an impediment to their application in clinical practice. Combined administration of two or more plant extracts with therapeutic efficacy may proffer solution to this menace. This study investigated the combined gastroprotective effects of Spondias mombin and Ficus exasperata leaf extracts against indomethacin-induced gastric ulcer in rats.
Materials and Methods: Thirty rats were randomized into six groups of five animals each and ulceration was induced by a single oral administration of indomethacin (30 mg/kg body weight). Ulcerated rats were orally administered with Spondias mombin, Ficus exasperata at 200 mg/kg body weight and esomeprazole (a reference drug) at a dose of 20 mg/kg body weight once daily for 21 days after ulcer induction. At the end of the experiment, gastric secretions and antioxidant parameters were evaluated.
Results: We observed that the significantly increased (P < 0.05) ulcer index, gastric acidity, malondialdehyde level and pepsin activity were markedly reduced following co-administration of S. mombin and F. exasperata. The extracts also effectively attenuated the reduced activities of superoxide dismutase and catalase as well as pH, mucin content and reduced glutathione level in the ulcerated rats.
Discussion and Conclusion: These findings are indicative of gastroprotective and antioxidative attributes of the two extracts which is also evident in the % protective index value obtained. The available evidences in this study suggest that the complementary effects of S. mombin and F. exasperata proved to be capable of ameliorating indomethacin-mediated gastric ulceration and the probable mechanisms are via antioxidative and proton pump inhibition.
EFFECTIVENESS OF WET-CUPPING IN TREATMENT OF BALB/C MICE INFECTED BY LEISHMANIA MAJOR; PILOT RANDOMIZED TRIAL
Authors: Karaji Ali Gorgin , Alipour Hamid , Ahmadi Alireza , Mohammadi Reza 
Published: June 2023

Background: Cutaneous leishmaniasis (CL) caused by Leishmania major is common in Middle East countries. Most therapies are limited and there is no effective vaccine for leishmaniasis. It has been reported that the ancient practice of wet cupping has been effective in treatment of drug resistant CL in humans. The purpose of this present study was to evaluate the efficacy of wet-cupping in treatment of L. major infected BALB/C mice.
Methods: We designed a randomized clinical trial using 12 male BALB/c mice, aged 8-10 weeks (six mice for each experimental and control group). Each mouse was infected with L. major on the left hind footpad. Mice in the experimental group underwent wet-cupping once a week, up to 6 weeks. The appearance of local reaction in the parasite inoculated paw was monitored and footpad thickness was measured for 7 weeks in both groups. Then all mice were killed and their spleen and lymph node cells were cultured and the level of IFN- γ and IL-4 of cultured cells supernatant were measured as the markers of TH1 and TH2, respectively.
Results: Lesion size thickness in the intervention mice seemed to grow faster than control ones. There were no significant differences in animal weight, spleen and lymph node weight and total cell number. The level of INF-γ and IL-4 produced by spleen cells of intervention mice was not significantly different from control mice (p=NS).
Conclusion: Our study showed that wet-cupping has no significant treatment effect on coetaneous leishmaniasis in BALB/c mice. Interestingly, the disease was more severe in the intervention group.
Social difficulties and costs/burden of adult Duchenne muscular dystrophy in Japan: A questionnaire survey based on the Japanese Registry of Muscular Dystrophy (Remudy)
Authors: Mori-Yoshimura Madoka , Ishigaki Keiko , Shimizu-Motohashi Yuko , Ishihara Naoko , Unuma Atushi , Yoshida Sumiko , Nakamura Harumasa 
Published: June 2023

Abstract

Background
Little is known about the social difficulties, economic burden, and health care needs of adult Duchenne muscular dystrophy (DMD) patients in Japan, as well as the financial and physical stress experienced by their caregivers. This study aimed to clarify the social circumstances surrounding adult DMD patients and assess the degree of involvement of family members in their care and the associated economic burden of the disorder in Japan.
Methods
Adult DMD patients were identified through the Registry of Muscular Dystrophy (Remudy) in Japan and invited to complete a questionnaire together with a caregiver. Data on health care use, quality of life, work status, informal care, and household expenses were collected to estimate the costs associated with DMD from social and caregiver household perspectives.
Results
In total, 234 (63.7%) of 367 adult DMD patients (mean age, 27.4 ± 6.0; range, 20–48 years) completed the questionnaire. Of these, 38 (21%) had developmental disorders (mental retardation, autism, and learning disorders), 57 (33%) experienced bullying in school, and 44 (77%) indicated the reason for bullying to be their physical handicap. Employment histories were noted by 72 (31%), although 23 (10%) lost their jobs mainly due to physical difficulties. Of the 234 patients, 164 (74%) lived with their relatives, and 78% of care time was supplied by family members, in particular, their mothers. The mean rate of care work provided by family members was 81%. Household income of families with an adult DMD patient was lower, whereas the rate of living with parent(s) and grandparent(s) was higher, in comparison with the general Japanese population.
Conclusions
Adult DMD patients in Japan experience many social difficulties from childhood up to adulthood. As adults, many DMD patients experience bullying and workplace difficulties. Families were found to provide most of the care and financial support for DMD patients. Our results suggest the need to improve public patient care systems, including financial support, to address the physical and economic burdens of care for adult DMD patients in Japan.
Salivary gland transcriptome analysis in Hirudinaria sp. during different feeding periods and functional studies of HspHirudin
Authors: Cheng Boxing , Hu Xiaoyun , Wang Suyan , Xie Xin , Shao Guiyan , Tian Qingqing , Gao Tianyi , Liu Fei 
Published: June 2023

Abstract

Background Hirudinaria sp., as one of the origins of leeches used in traditional Chinese medicine, is proved clinically effective in treating cardiovascular and cerebrovascular diseases. Substances with pharmacological activity are stored in salivary glands of leeches. Among these substances, hirudin exhibits high anti-thrombin activity. However, the structure, function and expression pattern of HspHirudin in Hirudinaria sp. distributed in Guangxi are still unclear.Methods and results Illumina HiSeq platform was used to obtain the transcriptome datasets of salivary glands from Hirudinaria sp. during different feeding periods. Unigenes which were significantly up-regulated after a blood meal and had functions related to the processes of blood meal ingestion were identified. The function of HspHirudin was studied based on gene cloning, bioinformatics analysis, prokaryotic expression analysis and anti-thrombin activity analysis, and its expression pattern was characterized by quantitative real-time PCR. The reads were assembled into 167564 unigenes, and ten genes with functions related to the processes of blood meal ingestion in salivary glands of Hirudinaria sp. were identified. After alignment, transcript (TRINITY_DN14935_c0_g2) was annotated to Hirudin-P6 (2E-31) from Poecilobdella manillensis and named HspHirudin. The HspHirudin cDNA was 249 bp in length, and it encodes a mature peptide of 82 aa and a signal peptide of 20 aa. The mature HspHirudin presented typical structural characteristics of hirudins: 3 pairs of disulfide bonds, the PKP and DFxxIP motifs. HspHirudin and Hirudin-P6 shared similar structure of N-terminus 3 aa and C-terminus, and their main differences were observed in the spherical structure domain. By constructing a prokaryotic expression system, HspHirudin was proven to have anti-thrombin activity. The high expression of HspHirudin mRNA was induced by bloodmeal feeding.Conclusions Ten genes with functions related to the processes of blood meal ingestion were screened from transcriptome datasets of salivary glands from Hirudinaria sp. during different feeding periods. Among them, HspHirudin, which belongs to the family of hirudins, has anti-thrombin activity. The results of the study provide theoretical basis for further development and utilization of Hirudinaria sp..
Factors associated with health-related quality of life among community-dwelling older adults: the APPCARE study
Authors: Bally Esmee LS , Korenhof Sophie A , Ye Lizhen , Grieken Amy van , Tan Siok Swan , Mattace-Raso Francesco , Procaccini Elena , Alhambra-Borrás Tamara , Raat Hein 
Published: June 2023

Abstract

This study aims to identify the factors associated with health-related quality of life (HRQOL) among community-dwelling older adults. Baseline and follow-up data from the ‘Appropriate care paths for frail elderly patients: a comprehensive model’ study were analysed. Physical and mental HRQOL were measured by the 12-item Short Form Health Survey (SF-12). Linear regression models were used to evaluate associations between sociodemographic, health, and lifestyle factors and HRQOL. The sample included 661 participants (mean age = 77.4 years; 47% female) from Rotterdam, the Netherlands. Frailty was negatively associated with physical (B = -6.14; P < 0.001) and mental (B = -7.06; P < 0.001) HRQOL. Similarly, participants with a higher score on activities of daily living limitations had lower physical (B = -1.08; P < 0.001) and mental (B = -0.24; P = 0.019) HRQOL. Female sex (B = -2.27; P < 0.001), multimorbidity (B = -2.83; P < 0.001), and a high risk of medication-related problems (B = -3.06; P < 0.001) were associated with reduced physical HRQOL, and loneliness (B = -3.73; P < 0.001) with reduced mental HRQOL. In contrast, higher age (B = 1.88; P = 0.022) and living alone (B = 3.48; P < 0.001) were associated with better mental HRQOL in the multivariate models. The findings of this study imply that future interventions aimed at promoting the health and autonomy of community-dwelling older adults could be tailored to subpopulations with relatively poor self-reported HRQOL, such as frail or lonely older adults.
Seroprevalence and Knowledge of Hepatitis B and C among Healthcare workers in three healthcare centers in Nasarawa State, Nigeria
Authors: Yakubu Ya’aba , Mojisola Owoseni , Ismaila Abioseabo Musa 
Published: June 2023

Abstract
Hepatitis B and C viruses are occupational risks for healthcare workers due to exposure to body fluids and blood of patients from percutaneous injuries. A major task in the health sector is to ascertain the burden of these diseases among healthcare workers in order to reduce its spread among caregivers and patients accessing care units. This study investigated the seroprevalence of viral hepatitis B and C infections among HCWs in three medical centers in Karu Local Government area, Nasarawa State. Sociodemographic data was collected through self-administered questionnaires for two Hundred and fifteen (215) healthcare workers of the three selected hospitals between January to March, 2019. Five (5mL) of whole blood samples were collected into Tri-potassium ethylenediamine tetraacetic acid (K3EDTA) container from individual participants and screened for Hepatitis B surface Antigen (HBsAg) and antibody to Hepatitis C Virus (anti -HCV). Data was processed and analysed using SPSS version 20 software. The overall seroprevalence of hepatitis among the HCWs were HBsAg 13.0%, HCV 2.8% and 0.3% were co-infected with both viruses. Percentage prevalence of HBsAg based on occupational status were Doctors 1.4%, Nurses 2.3%, Allied health care workers 3.2.0%, Administrative Staff 1.4% and unskilled workers 4.6%. The knowledge and awareness of viral hepatitis was high among Doctors (100%), Nurses (92%), and Allied health workers (80%) while a substantial percentage of the Administrative staff (27%) and unskilled workers (73%) had poor knowledge of the infectious pathogens. Not all respondents who are hepatitis B non-reactive have received hepatitis B vaccination. This study revealed the seroprevalence of disease burden and the significance of knowledge on the awareness of hepatitis B and C in vaccine uptake. The professional cadre, knowledge of HBV and HCV and Vaccine uptake were not associated with HBV and HCV status. Concerned authorities are expected to increase the knowledge and awareness of HBV and HCV among this group. Policies and guidelines of infection prevention and control practices should be implemented to ensure safety in a workplace environment.
Design and Implementation of IPE in the Python course
Authors: Zhang Ping , Wang Jianzhong 
Published: June 2023

Abstract
This article integrates the teaching content of Python programming course with Ideological and political (IP) education, and carries out the overall design of IP education In the Python course. Taking the turtle library, Jieba library, and Wordcloud library In the Python course as examples, a detailed design of IP education In the Python course is also carried out. Through the teaching design of IP education in this article, not only have the knowledge goals, ability goals, and emotional value goals of the python course been achieved, but also a way of thinking for other courses reforms and reference for other courses’ teachers to integrate IP concepts into their teaching.
Emotional gradients of characters in digital games and their impressions on users: the case of "THE IDOLM@STER SHINY COLORS"
Authors: Matsui Tetsuya 
Published: June 2023

Abstract
In this paper, I have conducted an analysis that contributes to the design of digital game characters that have a more positive effect on the player.
My focus in this paper is on the concept of "emotional gradient," which quantifies a character's emotional transition in a game.
From prior research, I hypothesize that there is an association between the emotional gradient and the character's "experience".
I tested this hypothesis using actual digital game characters that have been distributed.
I calculated the emotional gradient of each character by text mining.
At the same time, I measured the "experience" of each character through a web survey of game players.
I then examined the correlation between the value of the emotional gradient and "experience".
The results showed a significant correlation between the emotional gradient of JOY and SADNESS and "experience".
The results are useful for the design theory of digital game characters.
Comparing Natural Language Processing and Structured Medical Data to Develop a Computable Phenotype for Patients Hospitalized Due to COVID-19: Retrospective Analysis
Authors: Chang Feier , Krishnan Jay , Hurst Jillian H , Yarrington Michael E , Anderson Deverick J , O'Brien Emily C , Goldstein Benjamin A 
Published: June 2023

Abstract

Background
Throughout the COVID-19 pandemic, many hospitals conducted routine testing of hospitalized patients for SARS-CoV-2 infection upon admission. Some of these patients are admitted for reasons unrelated to COVID-19 and incidentally test positive for the virus. Because COVID-19–related hospitalizations have become a critical public health indicator, it is important to identify patients who are hospitalized because of COVID-19 as opposed to those who are admitted for other indications.

Objective
We compared the performance of different computable phenotype definitions for COVID-19 hospitalizations that use different types of data from electronic health records (EHRs), including structured EHR data elements, clinical notes, or a combination of both data types.

Methods
We conducted a retrospective data analysis, using clinician chart review–based validation at a large academic medical center. We reviewed and analyzed the charts of 586 hospitalized individuals who tested positive for SARS-CoV-2 in January 2022. We used LASSO (least absolute shrinkage and selection operator) regression and random forests to fit classification algorithms that incorporated structured EHR data elements, clinical notes, or a combination of structured data and clinical notes. We used natural language processing to incorporate data from clinical notes. The performance of each model was evaluated based on the area under the receiver operator characteristic curve (AUROC) and an associated decision rule based on sensitivity and positive predictive value. We also identified top words and clinical indicators of COVID-19–specific hospitalization and assessed the impact of different phenotyping strategies on estimated hospital outcome metrics.

Results
Based on a chart review, 38.2% (224/586) of patients were determined to have been hospitalized for reasons other than COVID-19, despite having tested positive for SARS-CoV-2. A computable phenotype that used clinical notes had significantly better discrimination than one that used structured EHR data elements (AUROC: 0.894 vs 0.841; P<.001) and performed similarly to a model that combined clinical notes with structured data elements (AUROC: 0.894 vs 0.893; P=.91). Assessments of hospital outcome metrics significantly differed based on whether the population included all hospitalized patients who tested positive for SARS-CoV-2 or those who were determined to have been hospitalized due to COVID-19.

Conclusions
These findings highlight the importance of cause-specific phenotyping for COVID-19 hospitalizations. More generally, this work demonstrates the utility of natural language processing approaches for deriving information related to patient hospitalizations in cases where there may be multiple conditions that could serve as the primary indication for hospitalization.