bluuebunny/crossref_metadata_2025_split huggingface dataset:
Validating galaxy clustering models with fixed and paired and matched-ICs simulations: application to primordial non-Gaussianities
Authors: Avila Santiago , Adame Adrian Gutierrez 
Published: December 2022

ABSTRACT
The Fix and Pair techniques were designed to generate simulations with reduced variance in the two-point statistics by modifying the initial conditions (ICs). In this paper we show that this technique is also valid when the ICs have local primordial non-Gaussianities (PNG), parametrized by fNL, without biasing the two-point statistics but reducing significantly their variance. We show how to quantitatively use these techniques to test the accuracy of galaxy/halo clustering models down to a much reduced uncertainty and we apply them to test the standard model for halo clustering in the presence of PNG. Additionally, we show that by Matching the stochastic part of the ICs for two different cosmologies (Gaussian and non-Gaussian) we obtain a large correlation between the (two-point) statistics that can explicitly be used to further reduce the uncertainty of the model testing. For our reference analysis (fNL = 100, $V=1 [\, h^{-1}\, {\rm Gpc} ]^3$, $n= 2.5\times 10^{-4}[\, h^{-1}\, {\rm Mpc}]^{-3}$, b = 2.32), we obtain an uncertainty of σ(fNL) = 60 with a standard simulation, whereas using Fixed [Fixed-Paired] ICs it reduces to σ(fNL) = 12 [σ(fNL) = 12]. When also Matching the ICs we obtain σ(fNL) = 18 for the standard case, and σ(fNL) = 8 [σ(fNL) = 7] for Fixed [Fixed-Paired]. The combination of the Fix, Pair, and Match techniques can be used in the context of PNG to create simulations with an effective volume incremented by a factor ∼70 at given computational resources.
Reconstructing orbits of galaxies in extreme regions (ROGER) III: Galaxy evolution patterns in projected phase space around massive X-ray clusters
Authors: Martínez Héctor J , Coenda Valeria , Muriel Hernán , de los Rios Martín , Ruiz Andrés N 
Published: December 2022

ABSTRACT
We use the roger code by de los Rios et al. to classify galaxies around a sample of X-ray clusters into five classes according to their positions in the projected phase space diagram: cluster galaxies, backsplash galaxies, recent infallers, infalling galaxies, and interlopers. To understand the effects of the cluster environment to the evolution of galaxies, we compare across the five classes: stellar mass, specific star formation rate, size, and morphology. Following the guidelines of Coenda et al., a separate analysis is carried out for red and blue galaxies. For red galaxies, cluster galaxies differ from the other classes, having a suppressed specific star formation rate, smaller sizes, and are more likely to be classified as ellipticals. Differences are smaller between the other classes, however backsplash galaxies have significantly lower specific star formation rates than early or recent infalling galaxies. For blue galaxies, we find evidence that recent infallers are smaller than infalling galaxies and interlopers, while the latter two are comparable in size. Our results provide evidence that, after a single passage, the cluster environment can diminish a galaxy’s star formation, modify its morphology, and can also reduce in size blue galaxies. We find evidence that quenching occurs faster than morphological transformation from spirals to ellipticals for all classes. While quenching is evidently enhanced as soon as galaxies get into clusters, significant morphological transformations require galaxies to experience the action of the physical mechanisms of the cluster for longer time-scales.
Impact of large-mass constraints on the properties of neutron stars
Authors: Ecker Christian , Rezzolla Luciano 
Published: December 2022

ABSTRACT
The maximum mass of a non-rotating neutron star, MTOV, plays a very important role in deciphering the structure and composition of neutron stars and in revealing the equation of state (EOS) of nuclear matter. Although with a large-error bar, the recent mass estimate for the black-widow binary pulsar PSR J0952–0607, i.e. M = 2.35 ± 0.17 M⊙, provides the strongest lower bound on MTOV and suggests that neutron stars with very large masses can, in principle, be observed. Adopting an agnostic modelling of the EOS, we study the impact that large masses have on the neutron-star properties. In particular, we show that assuming $M_{\rm TOV}\gtrsim 2.35\, {\rm M_\odot}$ constrains tightly the behaviour of the pressure as a function of the energy density and moves the lower bounds for the stellar radii to values that are significantly larger than those constrained by the NICER measurements, rendering the latter ineffective in constraining the EOS. We also provide updated analytic expressions for the lower bound on the binary tidal deformability in terms of the chirp mass and show how larger bounds on MTOV lead to tighter constraints for this quantity. In addition, we point out a novel quasi-universal relation for the pressure profile inside neutron stars that is only weakly dependent on the EOS and the maximum-mass constraint. Finally, we study how the sound speed and the conformal anomaly are distributed inside neutron stars and show how these quantities depend on the imposed maximum-mass constraints.
Genetic spectrum of CAKUT and risk factors for kidney failure: a pediatric multicenter cohort study
Authors: Liu Jia-Lu , Wang Xiao-Wen , Liu Cui-Hua , Gao Duan Ma5 Xiao-Jie , Jiang Xiao-Yun , Mao Jian-Hua , Zhu Guang-Hua , Zhang Ai-Hua , Wang Mo , Dang Xi-Qiang , Zhuang Jie-Qiu , Li Yu-Feng , Bai Hai-Tao , Zhang Rui-Feng , Shen Tong , BI Yun-Li , Sun Yu-Bo , Wang Xiang , Wu Bing-Bing , Chen Jing , Rao Jia , Tang Xiao-Shan , Shen Qian , Xu Hong ,   Chinese Children Genetic Kidney Disease Database (CCGKDD), “Internet Plus” Nephrology Alliance of the National Center for Children's Care Department of Nephrology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China
Published: December 2022

Abstract

Background
Congenital anomalies of the kidney and urinary tracts (CAKUT) are the leading cause of kidney failure in children with phenotypic and genotypic heterogeneity. Our objective was to describe the genetic spectrum and identify the risk factors for kidney failure in children with CAKUT.

Methods
Clinical and genetic data were derived from a multicenter network (Chinese Children Genetic Kidney Disease Database, CCGKDD) and the Chigene database. A total of 925 children with CAKUT who underwent genetic testing from 2014 to 2020 across China were studied. Data for a total of 584 children wereobtained from the CCGKDD, including longitudinal data regarding kidney function. The risk factors for kidney failure were determined by the Kaplan–Meier method and Cox proportional hazards models.

Results
A genetic diagnosis was established in 96 out of 925 (10.3%) children, including 72 (8%) with monogenic variants, 20 (2%) with copy number variants (CNVs), and 4 (0.4%)with major chromosomal anomalies. Patients with skeletal abnormalities were more likely to have large CNVs or abnormal karyotypes than monogenic variants. Eighty-two patients from the CCGKDD progressed to kidney failure at a median age of 13.0 (95% confidence interval, 12.4–13.6) years, and twenty-four were genetically diagnosed with variants of PAX2, TNXB, EYA1, HNF1B and GATA3 or the 48, XXYY karyotype. The multivariate analysis indicated that solitary kidney, posterior urethral valves, bilateral hypodysplasia, the presence of certain variants and premature birth were independent prognostic factors.

Conclusions
The genetic spectrum of CAKUT varies among different subphenotypes. The identified factors indicate areas that require special attention.
The Plastidial Glucan Phosphorylase Affects the Maltooligosaccharide Metabolism in Parenchyma Cells of Potato (Solanum tuberosumL.) Tuber Discs
Authors: Flores-Castellanos Junio , Fettke Joerg 
Published: December 2022

AbstractMaltodextrin metabolism is thought to be involved in both starch initiation and degradation. In this study, potato tuber discs from transgenic lines containing antisense constructs against the plastidial and cytosolic isoforms of α-glucan phosphorylase and phosphoglucomutase were used to evaluate their influences on the conversion of externally supplied glucose-1-phosphate into soluble maltodextrins, as compared to wild-type potato tubers (Solanum tuberosum L. cv. Desiree). Relative maltodextrin amounts analyzed by capillary electrophoresis with laser-induced fluorescence revealed that tuber discs could immediately uptake glucose-1-phosphate and use it to produce maltooligosaccharides with a degree of polymerization of up to 30, as opposed to tubers repressing the plastidial glucan phosphorylase. The results presented here support previous indications that a specific transporter for glucose-1-phosphate may exist in both the plant cells and the plastidial membranes, thereby allowing a glucose-6-phosphate-independent transport. Furthermore, it confirms that the plastidial glucan phosphorylase is responsible for producing longer maltooligosaccharides in the plastids by catalyzing a glucosyl polymerization reaction when glucose-1-phosphate is available. All these findings contribute to a better understanding of the role of the plastidial phosphorylase as a key enzyme directly involved in the synthesis and degradation of glucans and their implication on starch metabolism.
Phenomenological implications on a hidden sector from the festina lente bound
Authors: Ban Kayoung , Cheong Dhong Yeon , Okada Hiroshi , Otsuka Hajime , Park Jong-Chul , Park Seong Chan 
Published: December 2022

Abstract
We apply the festina lente (FL) bound on a hidden sector with U(1) gauge symmetries. Since the FL bound puts a lower bound on masses of particles charged under the U(1) gauge symmetries, it is possible to constrain the hidden sector even with a tiny coupling to the Standard Model. In particular, we focus on the phenomenological implications of the FL bound on milli-charged particles, which naturally arise when kinetic mixing between the photon and the hidden photon is allowed. It turns out that the milli-charged particle with the mass M ≲ 5 meV is prohibited by the FL bound in the case of a single hidden U(1), insensitively of the value of small kinetic mixing. This bound is crucial when bosonic dark matter is taken into consideration in this framework: the fuzzy bosonic dark matter models requesting minuscule masses are ruled out by the FL bound if the longevity of dark matter is protected by the hidden gauge symmetry.
Hitchin WKB-problem andP = Wconjecture in lowest degree for rank 2 over the 5-punctured sphere
Authors: Szabó Szilárd 
Published: December 2022

AbstractWe use abelianization of Higgs bundles away from the ramification divisor and fiducial solutions to analyze the large-scale behavior of Fenchel–Nielsen co-ordinates on the moduli space of rank 2 Higgs bundles on the Riemann sphere with five punctures. We solve the related Hitchin WKB problem and prove the lowest degree weighted pieces of the P = W conjecture in this case.
Phylogeographic analysis of Tula hantavirus highlights a single introduction to central Europe
Authors: Cirkovic Valentina , Dellicour Simon , Stamenkovic Gorana , Siljic Marina , Gligic Ana , Stanojevic Maja 
Published: December 2022

Abstract
Orthohantaviruses are zoonotic pathogens of humans, unique among the bunyaviruses in not being transmitted by an arthropod vector. Tula orthohantavirus (TULV) is an old-world hantavirus, of yet unclear human pathogenicity, with few reported cases of clinically relevant human infection. So far, phylogeographic studies exploring the global pathways of hantaviral migration are scarce and generally do not focus on a specific hantavirus species. The aim of the present study was to reconstruct the dispersal history of TULV lineages across Eurasia based on S segment sequences sampled from different geographic areas. Maximum-likelihood and Bayesian inference methods were used to perform the phylogenetic analysis and phylogeographic reconstructions. Sampling time and trapping localities were obtained for a total of 735 TULV S segment sequences available in public databases at the time of the study. The estimated substitution rate of the analyzed partial S segment alignment was 2.26 × 10–3 substitutions/site/year (95 per cent highest posterior density interval: 1.79 × 10−3 to 2.75 × 10–3). Continuous phylogeography of TULV S segment sequences placed the potential root and origin of TULV spread in the Black Sea region. In our study, we detect a single-lineage introduction of TULV to Europe, followed by local viral circulation further on.
“Whenever we exist on any land, we know it is our country”: Cocopa Mobility and the Colorado River in the U.S.-Mexico Borderlands, 1887–1936
Authors: Grant Daniel A 
Published: December 2022

Abstract
This article argues that between the 1890s and the 1920s, Cocopa Indians successfully parried the threats of expanding settler nation-states and modern capitalism by adapting ancestral mobility patterns to modern constraints of the U.S.-Mexico border. By moving with the changing flow of the Colorado River and, later, providing a cheap and indispensable migratory labor supply for both U.S. and Mexican farmers and ranchers, Cocopas were surprisingly successful at retaining autonomy within their ancestral homeland, even as both governments sought to enforce the international border and to colonize Cocopa lands. But a series of impediments eventually placed new and lasting limits on Cocopas’ abilities to move freely through their homeland of the Colorado River delta. A detailed account of how and why Cocopas moved, how and why state agents tried to limit their movements, and how and why both of these factors changed over time helps us understand why some Native peoples retained vestiges of autonomy within their ancestral homelands during an era commonly associated with genocide, displacement, or assimilation on both sides of the U.S.-Mexico border. This story shows us that Native movement was not only a geopolitical act but depended upon the specific landscapes in which it occurred. Long after the ink had dried on the map, this portion of the U.S.-Mexico border was rendered unstable by a river that knew no bounds and a people who knew how to move with it.
Audiological and Demographic Factors that Impact the Precision of Speech Categorization in Cochlear Implant Users
Authors: Colby Sarah , Seedorff Michael , McMurray Bob 
Published: December 2022

Objectives:
The ability to adapt to subtle variations in acoustic input is a necessary skill for successful speech perception. Cochlear implant (CI) users tend to show speech perception benefits from the maintenance of their residual acoustic hearing. However, previous studies often compare CI users in different listening conditions within-subjects (i.e., in their typical Acoustic + Electric configuration compared with Acoustic-only or Electric-only configurations) and comparisons among different groups of CI users do not always reflect an Acoustic + Electric benefit. Existing work suggests that CI users with residual acoustic hearing perform similarly to Electric-only listeners on phonetic voicing contrasts and unexpectedly poorer with fricative contrasts which have little energy in the range of the Acoustic + Electric listeners’ acoustic hearing. To further investigate how residual acoustic hearing impacts sensitivity to phonetic ambiguity, we examined whether device configuration, age, and device experience influenced phonetic categorization in a large individual differences study.

Design:
CI users with various device configurations (Electric-only N = 41; Acoustic + Electric N = 95) categorized tokens from five /b-p/ and five /s-ʃ/ minimal pair continua (e.g., bet-pet; sock-shock). We investigated age, device experience, and when applicable, residual acoustic hearing (pure tone hearing thresholds) as predictors of categorization. We also examined the relationship between phonetic categorization and clinical outcomes (CNC, AzBio) in a subset of our sample.

Results:
Acoustic + Electric CI users were better able to categorize along the voicing contrast (steeper categorization slope) compared with Electric-only users, but there was no group-level difference for fricatives. There were differences within the subgroups for fricatives: bilateral users showed better categorization than unilateral users and bimodal users had better categorization than hybrid users. Age was a significant factor for voicing, while device experience was significant for fricatives. Critically, within the Acoustic + Electric group, hybrid CI users had shallower slopes than bimodal CI users.

Conclusions:
Our findings suggest residual acoustic hearing is beneficial for categorizing stop voicing, but not frication. Age impacts the categorization of voicing, while device experience matters for fricatives. For CI users with ipsilateral residual acoustic hearing, those with better hearing thresholds may be over-relying on their acoustic hearing rather than extracting as much information as possible from their CI, and thus have shallower fricative categorization.
Screw Pullout Strength After Pedicle Screw Reposition: A Finite Element Analysis
Authors: Ye Yu-Xing , Huang Da-Geng , Hao Ding-Jun , Liu Jia-Yuan , Ji Jia-Jia , Guo Jin-Niu 
Published: December 2022

Research design.
Finite element analysis based on computed tomography images from the lumbar spine.

Objective.
Determined the pullout strength of unsatisfactorily placed screws and repositioned screws after unsatisfactory place in lumbar spine surgery.

Background.
Pedicle screws are widely used to stabilize the spinal vertebral body. Unsatisfactory screws could lead to surgical complications, and may need to be repositioned. Screw removal and reposition, however, may decrease pullout strength.

Methods.
We conducted a three-dimensional finite element analysis based on high-resolution computed tomography images from a 39-year-old healthy woman. Pullout strength was determined with the screw placed in different orientations at the same entry point (as selected by the Magerl method), as well as after removal and reposition. The material properties of the vertebral body and the screw were simulated by using grayscale values and verified data, respectively. A load along the screw axis was applied to the end of the screw to simulate the pullout.

Results.
The pullout strength was 1840.0 N with the Magerl method. For unsatisfactorily placed screws, the pullout strength was 1500.8 N at 20% overlap, 1609.6 N at 40% overlap, 1628.9 N at 60% overlap, and 1734.7 N at 80% overlap with the hypothetical screw path of the Magerl method. For repositioned screws, the pullout strength was 1763.6 N, with 20% overlap, 1728.3 N at 40% overlap, 1544.0 N at 60% overlap, and 1491.1 N at 80% overlap, with the original path. Comparison of repositioned screw with unsatisfactorily placed screw showed 14.04% decrease in pullout strength at 80% overlap, 5.21% decrease at 60% overlap, 7.37% increase at 40% overlap, and 17.51% increase at 20% overlap, with the screw path of the Magerl method.

Conclusions.
Removal and reposition increased the pullout strength at 20% and 40% overlap, but decreased the pullout strength at 60% and 80% overlap. For clinical translation, we recommend removal and reposition of the screw when the overlap is in the range of 20% to 40% or less. In vitro specimen studies are needed to verify these preliminary findings.
PHASE 2 RANDOMIZED STUDY (ORION-1) OF A NOVEL, BIODEGRADABLE DEXAMETHASONE IMPLANT (AR-1105) FOR THE TREATMENT OF MACULAR EDEMA DUE TO CENTRAL OR BRANCH RETINAL VEIN OCCLUSION
Authors: Singer Michael A. , Boyer David S. , Williams Stuart , McKee Hayley , Kerr Kevin , Pegoraro Tyler , Trevino Leo , Kopczynski Casey C. , Hollander David A. 
Published: December 2022

Purpose:
AR-1105 is a novel biodegradable sustained-release dexamethasone implant designed to deliver 6-month durability. This Phase 2 study evaluated two AR-1105 formulations with different release profiles in patients with macular edema due to retinal vein occlusion.

Methods:
Patients received a single intravitreal injection with 340 µg dexamethasone. In the initial phase, five patients received clinical formulation (CF) 1. In the randomized phase, 44 patients were randomized 1:1 to CF1 or CF2. The follow-up was 6 months. Patients had vision loss due to macular edema diagnosed ≥9 (central retinal vein occlusion) or ≥12 months (branch retinal vein occlusion) before screening, and could be treatment-naive or -experienced (if received prior steroids, must have demonstrated response).

Results:
Both formulations improved vision and reduced retinal thickening from baseline across all visits. At Month 6, mean changes in best-corrected visual acuity were +4.3 and +8.0 letters, and mean changes in central subfield thickness were −93 µm and −211 µm in CF1 and CF2 randomized patients, respectively. Most common adverse events were reduced visual acuity, worsening macular edema, conjunctival hemorrhage, and increased intraocular pressure. No patients required surgery or laser for intraocular pressure control.

Conclusion:
Both formulations were well tolerated and demonstrated clinically meaningful and sustained improvements in vision and retinal thickening in patients with retinal vein occlusion with longstanding edema.
Feasibility and Efficacy of a Non-Opioid Based Pain Management After Medical Thoracoscopy
Authors: Low See-Wei , Mullon John J. , Swanson Karen L. , Kern Ryan M. , Nelson Darlene R. , Fernandez-Bussy Sebastian , Sakata Kenneth K. 
Published: December 2022

Background:
Prescription opioids are a major cause of the opioid epidemic. Despite the minimally invasive nature of medical thoracoscopy (MT), data on the efficacy of non-opioid-based pain control after MT is lacking. The purpose of this study is to assess the feasibility and efficacy of a non-opioid-based pain management strategy in patients who underwent MT.

Methods:
We performed a retrospective analysis of all patients who underwent MT in the Mayo Clinic (Minnesota and Arizona) outpatient setting. We assessed their pain level and the need for analgesia post-MT from August 1, 2019, to May 24, 2021.

Results:
Forty patients were included. In the first 24 hours, 5/40 (12.5%) reported no pain. Twenty-eight patients out of 40 (70%) reported minor pain (pain scale 1-3), and 7/40 (17.5%) reported moderate pain (pain scale 4-6). No patients reported severe pain. Twenty-two out of 35 patients who experienced discomfort (63%) required acetaminophen, 6/35 patients (17%) required nonsteroidal anti-inflammatory drug, and 7/35 patients (20%) did not require analgesia. Of the 7 patients who had moderate pain, 5 (71%) reported that the moderate pain improved to mild at 72 hours post-MT. Zero patients required opioids, and none reported contacting any provider to manage the pain post-MT. Fourteen patients (78%) who had both parietal pleural biopsies and tunneled pleural catheter placed reported minor pain, 3 patients (17%) reported moderate pain, and 1 patient (6%) experienced no discomfort.

Conclusion:
MT is well-tolerated by patients with non-opioid-based pain management strategy as needed if there is no absolute contraindication.