bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of prognostic signature of cancer-associated fibroblasts associated with castration resistance prostate cancer based on Weighted Gene Co-expression Network Analysis
Authors: Zhang Wenjun , Che Bangwei , Liu Miao , Li Wei , Huang Tao , Yu Ying , Xu Shenghan , He Jun , Zha Cheng , Peng Zheng , Huang Kunyuan , Tang Kaifa 
Published: April 2023

Abstract
Prostate cancer (PCa) is the most common cancer in men and often progresses to castration resistant prostate cancer (CRPC) after treatment, with a poor prognosis. Cancer associated fibroblasts (CAF) are a major components of tumor microenvironment (TME), which participate in angiogenesis and immunosuppression, promote metastasis and treatment drug resistance. In order to identify the CAF prognostic genes associated with CRPC, the RNA sequencing data of 745 PCa patients from Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA) databases were downloaded. The CAF-related hub genes were identified by weighted gene co-expression network analysis (WCGNA). The CAF prognostic markers (FAP, SFRP2, COL1A1, VCAN) and signature were developed by machine learning methodology. Meanwhile, verified the CAF prognostic model could predict biochemical recurrence, metastasis and immunotherapy response. In addition, CAF infiltration was associated with immunosuppressive microenvironment, positively correlated with tumor mutation burden and “p53 downstream pathway”, “MET promotes cell motility pathway” and “TGF- β signal pathway”. subsequently, verified the CAF prognostic markers (FAP, SFRP2, COL1A1, VCAN) were specifically expressed in fibroblast cell lines, and the protein expression were located in stromal cells. In conclusion, these results indicated that CAF infiltration promoted the progression of PCa and associated with PCa recurrence and poor prognosis. The PCa prognostic signature has a potential clinical application value and the prognostic markers in CAF might be targets for inhibiting the progression of PCa.
On a nonlocal logistic equation with nonlinear advection term
Authors: DE LIMA ROMILDO , SOUTO MARCO , DUARTE RONALDO 
Published: April 2023

Abstract
Note: Please see pdf for full abstract with equations.
In this paper, we study a nonlocal logistic equation with nonlinear advection term$$\left\{\begin{array}{lcl}-\Delta u+\vec{\alpha}\cdot \nabla (|u|^{p-1}u)=\left(\lambda-\int_{\Omega}K(x,y)u^{\gamma}(y)dy \right)u,\mbox{ in }\Omega\\u=0,\mbox{ on }\partial\Omega\end{array}\right.\leqno(P)_p$$where $\Omega\subset\R^N$, $N\geq1$, is a bounded domain with smooth boundary, $\vec{\alpha}=(\alpha_1,\cdots,\alpha_N)$ is a flow satisfying suitable condition, $\gamma>0$, $p\geq1$, $\lambda\in\R$ and $K:\Omega\times\Omega\rightarrow\R$ is a nonnegative function with $K\in L^{\infty}(\Omega\times\Omega)$ and verifying other conditions that will be detailed below.
2020 Mathematics Subject Classification. 35B50, 35B51, 35J60.
Comparison of complications for cirrhotic versus non-cirrhotic patients undergoing pancreaticoduodenectomy
Authors: Zamorano Alicia Amairan G. , Valencia Paula Spang , Porrazzo Gina R. , Almerey Tariq , Stauffer John Andrew 
Published: April 2023

Abstract
Purpose
To compare the outcomes between patients with cirrhosis and those without who have undergone pancreatoduodenectomy (PD) in our institution.
Methods
A review of patients undergoing PD from the time period of January 2010 to December 2020 was performed. Patients that have undergone open or laparoscopic PD and had liver cirrhosis diagnosed prior to surgery were included and matched on a 1:2 basis with non-cirrhotic patients based on age, gender, Eastern Cooperative Oncology Group (ECOG) and date of surgery. Data was obtained from our medical records and ten major postoperative complications variables were compared to the matched group.
Results
Overall, 16 patients with cirrhosis were compared to 32 matched controls. No significant differences were found in pancreatic fistula (18.8% vs. 21.8%; P = 1.000), hemorrhage (6.3% vs. 6.2%; P = 1.000), delayed gastric emptying (6.3% vs. 15.6%; P = 0.648), wound infection (0% vs. 9.3%; P = 0.541) intraabdominal abscess (31.2% vs 6.2%; 0.4998) for cirrhotic vs. non-cirrhotic respectively. There were no postop ileus, gastric fistula, mesenteric portal thrombosis, biliary fistula, abdominal ischemic event in either group. The average length of stay for both groups was similar (6.9 vs. 9.3 days; P = 0.4019). There were no mortalities and major morbidity was similar (37.5% vs 34.3%;P = 0.3549). One patient required readmission for liver-related decompensation with full recovery.
Conclusion
PD in patients with cirrhosis can be safe and feasible in well-selected patients. In a high-volume institution, postoperative complications are similar to those patients without cirrhosis of the liver
Attention Inspiring Receptive-Fields Multi-Task Network via Self- supervised Learning for Violence Recognition
Authors: Li Suyuan , Song Xin 
Published: April 2023

Abstract
Generally, a large amount of training data is essential to train deep learning model for obtaining more accurate detection performance in computer vision domain. However, to collect and annotate datasets will lead to extensive cost. In this letter, we propose a self-supervised auxiliary task to learn general videos features without adding any human-annotated labels, aiming at improving the performance of violence recognition. Firstly, we propose a violence recognition method based on convolutional neural network with self-supervised auxiliary task, which can learn visual feature for improving down-stream task (recognizing violence). Secondly, we establish a balance-weighting scheme to solve the crucial problem of balancing the self-supervised auxiliary task and violence recognition task. Thirdly, we develop an attention receptive-field module, indicating that the proper use of the spatial attention mechanism can effectively expand the receptive fields of the module, further improving semantically meaningful representation of the network. To evaluate the proposed method, two benchmark datasets have been used, and better performance is shown by the experimental results comparing with other state-of-the-art methods.
On the stability of the Pexider system of bi-additive and bi-quadratic equations
Authors: Sayyari Yamin , Dehghanian Mehdi , Park Choonkil , Donganont Mana 
Published: April 2023

Abstract
In this paper, we solve a system of bi-additive and bi-quadratic equations and we study the Hyers-Ulam stability of the Pexider system of bi-additive and bi-quadratic equations.
AMS Subject Classification: Primary; 47B47, 17B40, 39B72, 47H10
The effectiveness of chlorine dioxide gas in portable personal disinfectants to inhibit bacterial growth
Authors: Ali Firdaus , Lestari Dwi Lintang , Putri Marsya Dyasthi , Azmi Khalidah Nurul 
Published: April 2023

Abstract

Disinfectants, especially air disinfectants, are necessary to prevent the potential spread of pathogens (bacteria and viruses) in the pandemic era and minimize the spread of pathogens. Some of the commercial disinfectant products that are often used generally contain chlorine dioxide (ClO2) gas. This study tested the effectiveness of two different commercial disinfectants, a liquid stick disinfectant and a powder disinfection card, to carry out the disinfection of pathogenic bacteria in the environment. These two disinfectants were used as a medium for releasing chlorine dioxide gas which has a much stronger bactericidal effect. In the form of liquid stick, ClO2 is more effective in the disinfection process rather than in the form of powder. The effectiveness of the liquid disinfectant in inhibiting the growth of pathogenic bacteria is influenced by the temperature and the area of the open space covered. Considering that the release from both disinfectants used is very small (0.002 ppmv/h), it takes a small area to ensure that the disinfection process runs effectively.
Reliability of stored river water as an alternative for consumption in Ekpoma, Nigeria: a human health risk assessment
Authors: Tenebe Imokhai T. , Babatunde Eunice. O. , Neris Jordan B. , Mikano Cephas , Ezeudu Obiora B. , Edo Onome C. , Fred-Ahmadu Omowunmi H. , Chukwuka Chibuike D. , Benson Nsikak U. 
Published: April 2023

Abstract

With looming global water-related issues, the monitoring of water quality for household and industrial consumption has become more pertinent. Rivers in nearby towns serve as primary water sources for Ekpoma town. 123 samples of stored river water were collected from 41 sampling locations and physical properties – pH, electrical conductivity (EC), salinity, temperature, and total dissolved solids (TDS) – were measured in situ using the Hanna edge® Multiparameter EC/TDS/Salinity Meter-HI2030. Atomic absorption spectrophotometry (AAS) was used to detect and measure the concentration of potentially toxic metals (PTMs): Al, Cr, Cu, Fe, Mn, Ni, Pb, and Zn. The measured concentrations were compared to the WHO, US EPA, and NSDWQ regulatory standards, and a spatiotemporal health risk analysis was performed using HERisk software. Twenty-five percent of the tested samples contained PTM concentrations within the allowable regulatory limits. Spatiotemporal health risk analysis showed that 98.8% of the cumulative carcinogenic risks (CRcum) were entirely from Pb contamination via oral ingestion. PTM concentrations in the samples suggest the degradation of river water quality due to agricultural activities, crude oil exploration activities, and soil composition in the region. Best management practices (BMPs) and treatment processes for the removal of detected contaminants are recommended to improve water quality.
HEC-RAS 2D modeling for flood inundation mapping: a case study of the Krishna River Basin
Authors: Vashist Komal , Singh K. K. 
Published: April 2023

Abstract
Floods are catastrophic natural disasters that cause a substantial toll on human lives, infrastructure, and the economy. Structural and non-structural measures are developed for planning flood mitigation strategies. Flood inundation mapping is valuable information for decision-makers and authorities to develop flood mitigation strategies and resource allocation. This study uses the HEC-RAS 2D model for flood inundation mapping in the Krishna River Basin. Digital elevation models (DEMs) of 12.5 and 30 m resolutions were used to model the inundation map. The study also investigated the effect of change in upstream boundary data on the inundated area. The simulated results with 12.5 m resolution DEM are found in good agreement with the validation data and conform to the inundated areas with the available reports. This study proves the 2D capabilities of HEC-RAS and helps the experts with better management practices.
Modification of a plant-scale semi-centralized wastewater treatment system to enhance nitrogen and phosphorus removal from black water
Authors: Niu Xinyuan , Bi Xuejun , Gu Ruihuan , Yin Zhixuan , Yang Benliang , Liu Changqing 
Published: April 2023

Abstract
Owing to the low ratio of chemical oxygen demand to total nitrogen (SCOD/TN), effective removal of nutrient pollutants from black water is difficult. In this study, to enhance nitrogen and phosphorus removal from such wastewater, a series of operational modification strategies was investigated and applied to a plant-scale semi-centralized system used for black water treatment. The results showed that 21 mg Fe3+/L was the optimal dosage for the chemical-enhanced pretreatment process, achieving average removal efficiencies of 51.1 and 74.1% for organics and phosphorus, respectively, with a slight enhancement in nitrogen removal by 2.3%. However, nitrogen and phosphorus removal could be further enhanced to 88 and 96%, by the addition of carbon sources in the post-anoxic zone of the reversed anaerobic–anoxic–aerobic process. Contrastingly, neither the addition of carbon sources in the pre-anoxic zone nor the prolongation of the time for pre-denitrification could significantly improve the nitrogen and phosphorus removal efficiencies. Furthermore, reducing the aeration intensity promoted simultaneous nitrification and denitrification in aerobic reactors, thereby making it a potential energy-saving method for system operation.
Research on the impact of China's new urbanization on industrial water utilization efficiency – based on spatial spillover effects and threshold characteristics
Authors: Shi Changfeng , Shang Teng , Zhi Jiaqi , Na Xiaohong 
Published: April 2023

Abstract
To explore the impact of new urbanization development on industrial water utilization efficiency, the epsilon-based measure model and the entropy method were used to calculate the industrial water utilization efficiency and the development of new urbanization based on the panel data of 30 provincial cities in China from 2011 to 2020. Then the spatial Durbin and the panel threshold models were constructed to explore the spatial spillover and threshold effects of new urbanization development on industrial water utilization efficiency. The results show that there are large regional differences in the development of new urbanization and industrial water utilization efficiency. New urbanization development has a positive spillover effects on the improvement of industrial water efficiency. The promotion effect of new urbanization development on industrial water efficiency is affected by the level of new urbanization development, thus showing different results. According to the findings, it is recommended that local governments at all levels should increase their efforts to build new urbanization. And boost high-level and high-quality development of towns and cities while promoting the rationalization of industrial structure and optimizing resource allocation, thereby improving the efficiency of industrial water utilization.
Efeito de espécies arbóreas no índice de calor do espaço circundante do município de Gurupi, Tocantins
Authors: Lorena Camargos de Souza  , Claudia Alicia Marín Pérez  , André Ferreira dos Santos  , Rodolfo Medeiros Trinetto  , Yusuky de Sousa Gomes  
Published: April 2023

A arborização urbana, ferramenta para mitigar o desconforto térmico, é cada vez mais considerada no desenho bioclimático. No Brasil, são poucos os estudos que trabalham com o Índice de Calor (IC) como ferramenta para diagnosticar o desconforto, embora haja várias pesquisas que têm tal índice como algo a ser avaliado. O presente estudo teve por objetivo avaliar o IC com base na caracterização e na análise da variabilidade de imediações das seguintes espécies arbóreas: Pachira aquática Aubl., Mangifera indica L., Caesalpinia pluviosa DC., Syzygium malaccense (L.) Merr. & LMPerry e Licania tomentosa (Benth.) Fritsch, existentes no setor central da cidade de Gurupi, Tocantins, durante todo o ano 2016. Foi possível observar as variações advindas dos raios de copa, bem como as variações sazonais e horárias. Os registros foram realizados a 0 m, 5 m, 10 m e 15 m do fuste da árvore, em horários próximos às 12 h e durante todo um ano, evidenciando as variações da variável por meio de tabelas e gráficos. Os resultados apontaram efeitos positivos das árvores de todas as espécies nas características estudadas, com atenuação média de 2ºC, com destaque para a espécie mangueira e as árvores de copa grande.
Palavras-chave: arborização urbana; conforto térmico; temperatura; umidade relativa.
Estimativa do estoque de carbono em um povoamento de Eucalyptus sp. de 25 anos estabelecido no Sul do Brasil
Authors: Mateus Alves Saldanha  , Alexsandra Cezimbra Quevedo  , Lucas José Mendes  , Roberta Rodrigues Roubuste  , Sally Déborah Pereira da Silva  , Mauro Valdir Schumacher  
Published: April 2023

O objetivo do presente estudo foi avaliar os estoques de carbono arbóreo de um povoamento de Eucalyptus sp. com aproximadamente 25 anos, em Santa Maria, região central do estado do Rio Grande do Sul, Brasil. Para isso, foram coletados dados de um povoamento de Eucalyptus sp., de 25 anos de idade, com espaçamento inicial de 4 m x 4 m, e estabeleceram-se aleatoriamente quatro parcelas de 30 m x 20 m para mensuração das variáveis diâmetro à altura do peito (DAP) e a altura total (H) de todas as árvores de cada parcela, utilizando-se fita diamétrica e hipsômetro Vertex IV, para posterior realização dos cálculos de área basal (g), volume (v) de cada árvore, quantificação da massa seca das árvores pelo método não destrutivo e estoque de carbono. Os valores médios encontrados para DAP e H foram 40,81 cm e 39,04 m, respectivamente, e a biomassa média total nas árvores de eucalipto foi 515,06 Mg.ha-1, com estoque médio total de carbono nas árvores de eucalipto de 242,08 Mg.ha-1. Dessa maneira, observa-se que o eucalipto apresenta grande potencial para alocação de biomassa e carbono orgânico por possuir rápido crescimento e elevada produtividade.
Palavras-chave: inventário florestal; plantações florestais; variáveis dendrométricas.
Molecular Connections between DNA Replication and Cell Death in
β-Amyloid-Treated Neurons
Authors: Caraci Filippo , Fidilio Annamaria , Santangelo Rosa , Caruso Giuseppe , Giuffrida Maria Laura , Tomasello Marianna Flora , Nicoletti Ferdinando , Copani Agata 
Published: April 2023

Background:
Ectopic cell cycle reactivation in neurons is associated with neuronal death in
Alzheimer’s disease. In cultured rodent neurons, synthetic β-amyloid (Aβ) reproduces the neuronal
cell cycle re-entry observed in the Alzheimer’s brain, and blockade of the cycle prevents Aβ-induced
neurodegeneration. DNA polymerase-β, whose expression is induced by Aβ, is responsible for the
DNA replication process that ultimately leads to neuronal death, but the molecular mechanism(s) linking
DNA replication to neuronal apoptosis are presently unknown.

Aim:
To explore the role of a conserved checkpoint pathway started by DNA replication stress, namely
the ATM-ATR/Claspin/Chk-1 pathway, in switching the neuronal response from DNA replication
to apoptosis.

Methods:
Experiments were carried out in cultured rat cortical neurons challenged with toxic oligomers
of Aβ protein.

Results:
Small inhibitory molecules of ATM/ATR kinase or Chk-1 amplified Aβ-induced neuronal
DNA replication and apoptosis, as they were permissive to the DNA polymerase-β activity triggered
by Aβ oligomers. Claspin, i.e., the adaptor protein between ATM/ATR kinase and the downstream
Chk-1, was present on DNA replication forks of neurons early after Aβ challenge, and decreased at
times coinciding with neuronal apoptosis. The caspase-3/7 inhibitor I maintained overtime the amount
of Claspin loaded on DNA replication forks and, concomitantly, reduced neuronal apoptosis by holding
neurons in the S phase. Moreover, a short phosphopeptide mimicking the Chk-1-binding motif of
Claspin was able to prevent Aβ-challenged neurons from entering apoptosis.

Conclusion:
We speculate that, in the Alzheimer’s brain, Claspin degradation by intervening factors
may precipitate the death of neurons engaged into DNA replication.
Konfigurasi Batang Pada Perancangan Rangka Atap Bambu
Authors: Rachmad Prihadi Wisnu , Nur Indriatno Putra Pratama Galeh 
Published: April 2023

ABSTRACT This study discusses the system design roof truss on a wide span which spans 15 m using bamboo materials, it is deemed necessary because of the material bamboo is a material that is readily available and can be used as themporary shelter as a temporary shelter disaster victims, therefore it needs to be done a review of some particular configuration rod placement diagonal rods. The purpose of the configuration of the rod is to obtain an optimal and efficient structure and implement connection system Moriscos on bamboo construction. On the pedestal roof frame is at the point of the column, so that in this condition is considered the foundation of the joints with horizontal movement of the pedestal reason restrained by anchor bolts and added restrained also by friction contact area of the pedestal. In this modeling study using bamboo material strap (Gigantochloa lear kurz) diameter of 6 cm, as a truss, and use the program SAP 2000 version 14 as a tool in calculating the truss. from reviewing several models from the rafters with bamboo material shows that the stiffness criterion for diagonal rod configuration on the model B which show the predicted vertical deflection z direction is small. As for the efficiency criteria in terms of style rod rod press (compression) due to the effect of buckling (buckling), various models have the smallest is the model A. Keywords: bamboo, design, roof truss. ABSTRAK Kajian ini membahas perancangan sistem rangka atap pada bentang yang lebar yaitu bentang 15 m dengan menggunakan material bambu, hal ini dirasa perlu karena material bambu merupakan material yang mudah didapat dan dapat digunakan sebagai themporary shelter sebagai tempat tinggal sementara korban bencana, oleh karena itu perlu dilakukan peninjauan terhadap beberapa konfigurasi penempatan batang khususnya batang diagonal. Tujuan dari konfigurasi batang tersebut adalah untuk mendapatkan struktur yang optimal dan efisien serta menerapkan sistem sambungan morisco pada konstruksi bambu. Pada tumpuan rangka atap berada pada titik kolom, sehingga dalam kondisi ini tumpuan dianggap sendi-sendi dengan alasan pergerakan horizontal tumpuan tertahan oleh angkur baut serta ditambahkan tertahan juga oleh gesekan bidang kontak tumpuan. Kajian permodelan ini menggunakan material bambu tali (gigantochloa apus kurz) berdiameter 6 cm, sebagai bahan rangka batang, dan menggunakan program SAP 2000 versi 14 sebagai alat bantu dalam menghitung struktur rangka batang dari peninjauan beberapa model dari rangka atap dengan material bambu menunjukkan bahwa untuk kriteria kekakuan maka konfigurasi batang diagonal pada model B yang menunjukkan prediksi defleksi vertikal arah z yang kecil. Sedangkan untuk kriteria efisiensi batang ditinjau dari gaya batang tekan (compression) karena pengaruh tekuk (buckling), dari berbagai model dipilih yang terkecil adalah model A. Kata Kunci: bambu, perancangan, rangka atap.