bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy and safety of intravenous glucocorticoid therapy for IgG4-related ophthalmic disease
Authors: Yang Min Kyu , Kim Gye Jung , Choi Yeong A. , Sa Ho-Seok 
Published: April 2023

Purpose
To evaluate and compare the efficacy and safety of intravenous (IV) glucocorticoid therapy with those of oral glucocorticoids as a first-line treatment for IgG4-related ophthalmic disease (IgG4-ROD).

Methods
We retrospectively reviewed the medical records of patients who underwent systemic glucocorticoid therapy for biopsy-proven IgG4-ROD from June 2012 to June 2022. Glucocorticoids were given either oral prednisolone at an initial dose of 0.6 mg/kg/day for four weeks with subsequent tapering or once weekly IV methylprednisolone (500 mg for six weeks, then 250 mg for six weeks), according to the date of treatment. Clinicoserological features, initial response, relapse during follow-ups, cumulative doses of glucocorticoids, and adverse effects of glucocorticoids were compared for the IV and oral steroid groups.

Results
Sixty one eyes of 35 patients were evaluated over a median follow-up period of 32.9 months. The complete response rate was significantly higher in the IV steroid group (n = 30 eyes) than in the oral steroid group (n = 31 eyes) (66.7% vs. 38.7%, p = 0.041). Kaplan–Meier analysis showed that the 2-year relapse-free survival was 71.5% (95% confidence interval: 51.6–91.4) and 21.5% (95% confidence interval: 4.5–38.5) in the IV steroid and oral steroid group, respectively (p < 0.001). Although the cumulative dose of glucocorticoids was significantly higher in the IV steroid group than in the oral steroid group (7.8 g vs. 4.9 g, p = 0.012), systemic and ophthalmic adverse effects were not significantly different between the two groups throughout follow-ups (all p > 0.05).

Conclusions
As a first-line treatment for IgG4-ROD, IV glucocorticoid therapy was well-tolerated, led to better clinical remission and more effectively prevented inflammatory relapse than oral steroids. Further research is needed to establish guidelines on dosage regimens.
Effect of socioeconomic status and healthcare provider on post-transplantation care in Malaysia: A multi-centre survey of kidney transplant recipients
Authors: Gan Kim Soon Peter , Rampal Sanjay , Lim Soo Kun , Su Tin Tin 
Published: April 2023

Introduction
As the rate of end-stage kidney disease rises, there is an urgent need to consider the catastrophic health expenditure of post-transplantation care. Even a small amount of out-of-pocket payment for healthcare can negatively affect households’ financial security. This study aims to determine the association between socioeconomic status and the prevalence of catastrophic health expenditure in post-transplantation care.

Method
A multi-centre cross-sectional survey was conducted in person among 409 kidney transplant recipients in six public hospitals in the Klang Valley, Malaysia. Catastrophic health expenditure is considered at 10% out-of-pocket payment from household income used for healthcare expenditure. The association of socioeconomic status with catastrophic health expenditure is determined via multiple logistic regression analysis.

Results
93 kidney transplant recipients (23.6%) incurred catastrophic health expenditures. Kidney transplant recipients in the Middle 40% (RM 4360 to RM 9619 or USD 1085.39 –USD 2394.57) and Bottom 40% (<RM 4,360 or < USD 1085.39) income groups experienced catastrophic health expenditure compared to the Top 20% (>RM 9619 or > USD 2394.57) income group. Kidney transplant recipients in the Bottom 40% and Middle 40% income groups were more susceptible to catastrophic health expenditure at 2.8 times and 3.1 times compared to higher-income groups, even under the care of the Ministry of Health.

Conclusion
Universal health coverage in Malaysia cannot address the burden of out-of-pocket healthcare expenditure on low-income Kidney transplant recipients for long-term post-transplantation care. Policymakers must reexamine the healthcare system to protect vulnerable households from catastrophic health expenditures.
Cemiplimab-Associated Sinusoidal Obstruction Syndrome
Authors: Sarsour Nadeen Y. , Minervini Marta , Malik Shahid M. 
Published: April 2023

ABSTRACT
A 58-year-old woman developed new-onset recurrent ascites after the recent initiation of cemiplimab for the treatment of advanced basal cell carcinoma. A comprehensive serological workup for viral, metabolic, and autoimmune causes was unrevealing. Transjugular liver biopsy demonstrated parenchymal changes consistent with a diagnosis of sinusoidal obstruction syndrome. While this is a condition commonly observed in patients after hematopoietic stem cell transplantation or use of chemotherapeutic agents, it should also be considered in patients who develop new-onset liver dysfunction after the initiation of checkpoint inhibitors.
Geometric arcs and fundamental groups of rigid spaces
Authors: Achinger Piotr , Lara Marcin , Youcis Alex 
Published: April 2023

AbstractWe develop the notion of ageometric coveringof a rigid space 𝑋, which yields a larger class of covering spaces than that studied previously by de Jong. Geometric coverings are closed under disjoint unions and are étale local on 𝑋. If 𝑋 is connected, its geometric coverings form a tame infinite Galois category and hence are classified by a topological group. The definition is based on the property of lifting of “geometric arcs” and is meant to be an analogue of the notion developed for schemes by Bhatt and Scholze.
Norms versus Interpretations: Human Rights Universality Revisited
Authors: García Escobar Gabriela 
Published: April 2023

AbstractDebates on human rights universality frame universality according to an anthropological view called Western universalism and consider that “cultural relativism” is equivalent to any other framework. Thus, the discussion on this topic has been reduced to who is the rights-holder and the concept of human rights itself. There is a third approach to universality that must be addressed: the universality of interpretations. Most critics of human rights universality do not contest internationally agreed human rights norms (as established in treaties). Rather, they react against interpretations or standards as have been developed by human rights mechanisms. Accordingly, this paper explores three positions that have been developed around this notion: flexible Westerns, dialogical perspectives, and bottom-up approaches.
Production and characterization of Al–Cu binary alloy produced by using novel continuous casting process
Authors: Biswas Prasenjit , Patel Deepak , Kundu Amrik , Poddar Shashank , Kundu Arjun , Mallik Archana , Das Sanjeev 
Published: April 2023

Abstract
Aluminium (Al) and its constituent alloys has been consistently favoured as a promising material for industrial applications. In conventional casting technique of Al alloys, alloying elements are amalgamated in molten pool of Al melt followed by manual skimming. In contrast, batch type manufacturing includes intrinsic mixing and casting discontinuity, which negatively impacts the flexibility and cost-effectiveness of the process, resulting in a decline in the overall efficacy of the process. In the present study, a novel continuous casting processing route has been used to make Al–Cu binary alloys of different compositions. The newly designed technique makes use of a novel mechanical force convection technology, as well as bottom feeding of the molten metal and alloying element throughout the manufacturing process. The bottom feeding along with rotational swirl ensures better amalgamation of alloying element. Feed rates of Al melt and Al–Cu master alloy were mathematically modelled to obtain the desired alloy composition. The microstructural characterization of the developed alloys exhibit Al–Cu intermetallic phase invariably distributed throughout the sample, which concludes a better performing processing route to prepare Al–Cu binary alloys.
»Geringe Produktivität auf teilweise recht uninteressanten Randgebieten«?
Authors: Pöhlmann Markus 
Published: April 2023

Zusammenfassung
Zwischen 1979 und 2008 gab das Militärgeschichtliche Forschungsamt der Bundeswehr (MGFA) das zehnbändige Reihenwerk »Das Deutsche Reich und der Zweite Weltkrieg« heraus. Dieses Werk stellt einen frühen und bedeutenden Versuch dar, in der Bundesrepublik militärische Zeitgeschichte zu schreiben. Der Aufsatz untersucht die Konzeption des Reihenwerkes in den Aufbaujahren des MGFA zwischen 1957 und 1972. Ziel ist es, über die Entstehungsgeschichte des Forschungsprodukts weitergehende Erkenntnisse zur Organisation, zum Personalkörper und zum wissenschaftlichen Selbstverständnis des MGFA gewinnen. Damit soll auch ein Beitrag zur Geschichte der Ressortforschung im Bereich des Bundesministeriums der Verteidigung während einer wichtigen Phase des gesellschaftlichen Wandels in der Bundesrepublik geleistet werden.
5-Amino-2-chloro-4-fluoro-N-(N-isopropyl-N-methylsulfamoyl) benzamide, C11H15O3ClFN3S
Authors: Jie Wang , Xiao Shu-Zhen , Cong Huang , Liu Ya-Qiang , Peng Da-Yong 
Published: April 2023

Abstract
C11H15O3ClFN3S, triclinic,

P

1
‾

$P\overline{1}$

(no. 2), a = 7.8107(11) Å, b = 9.1644(13) Å, c = 11.3521(15) Å, α = 67.543(2)°, β =

72.776

(
2
)

∘

$72.776{(2)}^{\circ }$

, γ =

88.529

(
2
)

∘

$88.529{(2)}^{\circ }$

, V = 713.76(17) Å3, Z = 2,

R

g
t

${R}_{\mathit{g}\mathit{t}}$

(F) = 0.0385,

w

R

r
e
f

$w{R}_{\mathit{r}\mathit{e}\mathit{f}}$

(F
2) = 0.1338, T = 296(2) K.
The influence of fibrous suspension flow regimes on the formation of tissue paper manufactured from different furnish compositions
Authors: Mendes Afonso H. T. , Park Song W. 
Published: April 2023

AbstractThe present work was based on analysis of the flow regime of fibre suspensions, that corresponds to furnishes and process conditions typically established for tissue paper manufacturing,i.e., under the common range of stock consistencies at the machine headbox and most usual furnish compositions. The flocculation potential of fibre suspensions used for toilet papers, facial tissues, paper towels and table napkins were evaluated on the principles of analytical concepts for fibre agglomeration propensity. The results show crowding numbers from 5.0 to 69.0, depending on the type of fibre or fibre blending ratios. The findings regarding agglomeration factors indicate that flow regimes are mainly in semi-concentrated and around gel state zones but reached the concentrated flow regime, in extreme conditions of fibre morphology and stock consistency. The influence of hardwood and softwood mixture ratios on the fibre suspension features is shown and discussed for common formulations of tissue base paper. The effect of fibre length and coarseness on the flocculation potential and the impacts of fibre suspension flow regimes on the structural properties of tissue paper, such as the formation uniformity are discussed, demonstrating the reasons for the preferred use of high hardwood content in furnish balance for tissue paper manufacturing.
The Impact of Transportation on Pottery Industries in Roman Britain
Authors: Wiseman Rob , Bulik Olivia , Lobo José , Lodwick Lisa , Ortman Scott G. 
Published: April 2023

Abstract
The distribution of Roman pottery depended on the transportation system which moved it. Here we trace developments in these distributions during the Roman period in Britain to document how the transportation system developed and assess its impact on the island’s economy. We created a database with records from 775 excavations at 652 sites, and data on over two million pottery sherds. By analyzing the changing distributions of pottery from production centers, we are able to measure improvements in the Roman transportation system over time. These improvements seem to have been most rapid soon after conquest, with transport costs almost halving in the first century of Roman occupation. As the road network expanded and transportation technology improved and pottery gained access to wider markets, producers’ dominance over their local markets declined as rival products became more accessible, and certain industries dramatically increased their outputs. Production by small industries fell in our Middle and Later Roman periods.
Naturalistic spoken language comprehension is supported by alpha and beta oscillations
Authors: Zioga Ioanna , Weissbart Hugo , Lewis Ashley G. , Haegens Saskia , Martin Andrea E. 
Published: April 2023

Brain oscillations are prevalent in all species and are involved in numerous perceptual operations. Alpha oscillations are thought to facilitate processing through the inhibition of task-irrelevant networks, while beta oscillations are linked to the putative reactivation of content representations. Can the proposed functional role of alpha and beta oscillations be generalized from low-level operations to higher-level cognitive processes? Here we address this question focusing on naturalistic spoken language comprehension. Twenty-two (18 female) Dutch native speakers listened to stories in Dutch and French while magnetoencephalography (MEG) was recorded. We used dependency parsing to identify three dependency states at each word: the number of (1) newly opened dependencies, (2) dependencies that remained open, and (3) resolved dependencies. We then constructed forward models to predict alpha and beta power from the dependency features. Results showed that dependency features predict alpha and beta power in language-related regions beyond low-level linguistic features. Left temporal, fundamental language regions are involved in language comprehension in alpha, while frontal and parietal, higher-order language regions, and motor regions are involved in beta. Critically, alpha- and beta-band dynamics seem to subserve language comprehension tapping into syntactic structure building and semantic composition by providing low-level mechanistic operations for inhibition and reactivation processes. Due to the temporal similarity of the alpha-beta responses, their potential functional dissociation remains to be elucidated. Overall, this study sheds light on the role of alpha and beta oscillations during naturalistic spoken language comprehension, providing evidence for the generalizability of these dynamics from perceptual to complex linguistic processes.SIGNIFICANCE STATEMENT:It remains unclear whether the proposed functional role of alpha and beta oscillations in perceptual and motor function is generalizable to higher-level cognitive processes, such as spoken language comprehension. We found that syntactic features predict alpha and beta power in language-related regions beyond low-level linguistic features when listening to naturalistic speech in a known language. We offer experimental findings that integrate a neuroscientific framework on the role of brain oscillations as “building blocks” with spoken language comprehension. This supports the view of a domain-general role of oscillations across the hierarchy of cognitive functions, from low-level sensory operations to abstract linguistic processes.
Acute onset of diabetes and rapid cognitive decline in a patient with mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes syndrome
Authors: Tran Nam Quang , Phan Chien Cong , Vuong Tran Bao , Tran Thang Viet , Ma Phat Tung 
Published: April 2023

Summary
Mitochondrial diseases are a group of rare diseases presenting with heterogeneous clinical, biochemical, and genetic disorders caused by mutations in the mitochondrial or nuclear genome. Multiple organs can be affected, particularly those with high energy demand. Diabetes is a common endocrine manifestation of mitochondrial diseases. The onset of mitochondrial diabetes can be latent or acute, and the presenting phenotype can be type 1- or type 2-like. Studies show that diabetes ais associated with latent progression of cognitive decline in patients with mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome. Herein, we report a case of rapid cognitive decline after the acute onset of diabetes in a patient with MELAS syndrome. The patient was a 36-year-old woman who was hospitalized due to hyperglycemic crisis and seizures. She was diagnosed with MELAS syndrome two years previously, and had gradually progressing dementia and hearing loss. However, following the acute onset of diabetes, she developed rapid cognitive decline and loss of ability to perform daily activities. In conclusion, the acute onset of diabetes could be an associated risk factor for rapid cognitive decline in patients with MELAS syndrome. Thus, these patients as well as healthy carriers with related genetic mutations should undergo diabetes education and screening tests. Moreover, clinicians should be aware of the possibility for acute onset of hyperglycemic crisis, particularly in the presence of triggering factors.

Learning points

Diabetes is a common endocrine manifestation of mitochondrial diseases, presenting with a type 1- or type 2-like phenotype depending on the level of insulinopenia.

Metformin should be avoided in patients with mitochondrial diseases to prevent metformin-induced lactic acidosis.

Mitochondrial diabetes can manifest before or after the onset of MELAS syndrome.

In patients with MELAS syndrome, diabetes can initially manifest with a life-threatening severe hyperglycemic crisis and can cause rapid cognitive decline.

Diabetes screening tests (e.g. hemoglobin A1c, oral glucose tolerance test, or random blood glucose level measurement) should be performed either systematically or in the presence of symptoms, particularly after triggering events.

Genetic testing and counseling should be provided to patients and their families for the purpose of better understanding the inheritance, progression, and possible outcomes of the disease.
Flujo, herida, clamor. Responder a monstruosa tierra. Una lectura de leviathan de Jonathan Pimentel
Authors: Soto Morera Diego A. 
Published: April 2023

This paper proposes a review of Monstruosa tierra. Una lectura de Leviathan by the Costa Rican theologian Jonathan Pimentel Chacón. The main goal of this document is to show how some central categories and problems of Monstruosa tierra, particularly its notion of flesh, are related to a broader threshold within the inquiry of its author. From this perspective, the exercise suggests an understanding of the development of some primary ideas throughout Pimentel Chacón’s work, its variation during different periods and integration within the recent research conflicts of its author. At the end of this text, it is discussed the methodological precautions motivated by Monstruosa tierra regarding the reception of principal references within the traditions of political and economic thought.
Point-of-Care Ultrasound in Children With Medical Complexity
Authors: Kharasch Sigmund J. , Dumas Helene , Huang Calvin , Liteplo Andrew , Shokoohi Hamid , Kharasch Virginia 
Published: April 2023

BACKGROUND AND OBJECTIVES
Children with medical complexity (CMC) have significant chronic health conditions that involve congenital or acquired multisystem disease associated with medical fragility, functional limitations, dependence on technology, and high health care utilization. The objective of this study was to describe the indications, applications, and point-of-care ultrasound (POCUS) findings in this population.

METHODS
A descriptive study of POCUS scans performed for clinical purposes in CMC admitted to a single pediatric postacute care hospital. All children for whom a POCUS was requested by a medical team provider were eligible for inclusion.

RESULTS
One hundred and four POCUS evaluations were performed for 33 patients. Diagnostic groups for the 33 patients included multiple congenital anomalies (41%), neurologic or neuromuscular (31%), prematurity (25%) and cardiac (3%). Lung, cardiac, and diaphragmatic ultrasound accounted for 57% of POCUS requested. POCUS was abnormal in 82% of diaphragmatic, 73% of lung, and 11% of cardiac ultrasounds. Twenty-three percent of POCUS studies were requested to answer a specific clinical question, 56% for follow-up information, and 21% for baseline evaluation.

CONCLUSIONS
Lung, diaphragmatic, and cardiac ultrasound were the most prevalent POCUS studies requested in a postacute care hospital. POCUS may offer an expanded role in such patients and settings by answering clinical questions and by providing baseline and follow-up information.
Мовна репрезентація гендеру на сторінках журналу «Кур’єр Кривбасу»
Authors: Poplavska Nataliya , Tsepkalo Tetiana 
Published: April 2023

У статті наголошено, що медіа є чи не основним каталізатором гендерних проблем, обгрутовано необхідність їх дослідження. Схарактеризовано українські літературно-художні часописи як медійні платформи для обговорення літературних процесів та книговидавання, які презентували читачам широку палітру нових письменницьких постатей, заборонених творів, стали репрезентантами стану у сфері продукування художніх текстів. На основі моніторингу художніх творів, опублікованих на сторінках літературно-мистецького журналу «Кур’єр Кривбасу» початку ХХІ ст., доведено, що мовна репрезентація гендеру відзначена відповідною стереотипізацією. Звернено увагу на явище сексизму в текстах, який оприявнено через родові іменники та займенники, що використовуються в чоловічому роді на позначення представників обох статей, спрощення мовних виявів та економію лінгвістичного ресурсу, стереотипний опис фізіологічних та психологічних якостей жінок, лексеми, що принижують їх гідність, та слова зневажливого характеру. Виокремлено лексичні лакуни та безеквівалентні слова на позначення професій чоловіків і жінок стосовно відсутності відповідника в іншій родовій приналежності, процес фемінітивізму як спосіб делакунізації, встановлено роль використання фемінітивів для закріплення соціального статусу жінок, способи їх творення (суфіксальний, словоскладання, калькування тощо).
У статті для проведення аналізу лінгвістичної репрезентації гендеру використано системно-структурний аналіз, функціональний підхід — до вивчення мовної специфіки художніх текстів, описовий метод — для інтерпретації маскулінних та фемінних стереотипів і їх прояву в мові, а також методи систематизації та узагальнення, контент-аналіз.