bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interviewer judgment-making as a social practice: Insights from an institutional observational study in postgraduate selection
Authors: Roberts Chris , Annette Burgess , Mossman Karyn , Kumar Koshila 
Published: June 2023

Abstract
Background Interviewers’ judgements play a critical role in competency-based assessments for selection such as the multiple-mini-interview. ((MMI) Much of the published research focuses on the psychometrics of selection and the impact of rater subjectivity. Within the context of selecting for entry into specialty postgraduate training, we used an interpretivist and socio-constructivist approach to explore how and why interviewers make judgments in high stakes selection settings whilst participating in a multiple-mini-interview (MMI).Methods We explored MMI interviewers’ work processes through an institutional observational approach, based on the notion that interviewers’ judgements are socially constructed and mediated by multiple factors. We gathered data through document analysis, and observations of interviewer training, candidate interactions with interviewers, and interviewer meetings. Interviews included informal encounters in a large selection centre. Data analysis balanced description and explicit interpretation of the meanings and functions of the interviewers’ actions and behaviours.Results Three themes were developed from the data showing how interviewers make professional judgements, specifically by; ‘Balancing interplay of rules and agency,’ ‘Participating in moderation and shared meaning making; and ‘A culture of reflexivity and professional growth.’ Interviewers balanced the following of institutional rules with making judgment choices based on personal expertise and knowledge. They engaged in dialogue, moderation, and shared meaning with fellow interviewers which enabled their consideration of multiple perspectives of the candidate’s performance. Interviewers engaged in self-evaluation and reflection throughout, with professional learning and growth as primary care physicians and supervisors being an emergent outcome.Conclusion This institutional observational study of interviewers at work in an MMI gives rich insight into the social and contextual nature of judgment-based decision-making in the postgraduate selection process, and emergent outcomes relating to the professional growth of interviewers. Reframing interviewer judgement-making as a social practice provides ways to re-design approaches to interviewer training and selection tool design.
A spectrum of nonsense-mediated mRNA decay efficiency along the degree of mutational constraint
Authors: Kim Jong-Won , Kim Young-gon , Kang Hyunju , Lee Beomki , Jang Hyeok-Jae , Park Jong-ho , Ha Changhee , Park Hogun 
Published: June 2023

Abstract
A landmark study has proposed several factors on nonsense-mediated mRNA decay (NMD) efficiency using matched genome and transcriptome data of human cancer but was highly affected by random variance caused by the indirect measure of NMD efficiency. In this study, using a more direct, allele-specific expression-based measure of NMD efficiency, a more precise NMD efficiency model was developed. Combining this model with the public germline variant database stratified by allele frequency, we showed that there is a spectrum of NMD efficiency, from common variants to somatic variants in the cancer genome. The spectrum in NMD efficiency was also evident from the change in the gene-level mutational constraint measured by the loss-of-function observed/expected upper bound fraction (LOEUF). Based on the clear association observed between the NMD efficiency and LOEUF, we propose that NMD may be a key player in shaping the landscape of gene-level mutational constraint.
Research and Experiment on the Trenching Performance on Orchard Trenching Device
Authors: ma chen , meng hewei , zhang jian , zhang cong , zhao ying , Wang LiHong 
Published: June 2023

Abstract

The theory analysis of trenching cutting operation was carried out to find out the law of the influence of the cutter head combination and working parameters on the operation of the disc trenching device. The influence of trenching parameters on trenching trajectory, performance and quality was obtained. The response surface method was applied to design and carry out field experiments. With the increase of cutter head speed and forward speed, the width and depth of trenching and the thickness of floating soil at the bottom of trenching decreased first and then increased, while the operation power consumption presented the increasing trend gradually. The optimization model of trenching performance quality was constructed to obtain the optimal parameter combination of influencing factors. Field experiments were carried out to verify the optimization results. The results showed that the optimization model could meet the operation quality indexes, and provide a theoretical basis for the design of the disc subsection cutting trenching device to select the operation parameter combination required by low power consumption and deep trenching.
Prevalence and Determinants of Intimate Partner Violence Among Antenatal Care Attendees in Case of Adama Hospital Medical College
Authors: Bedada Tigist , Girma Fraol , Bayissa Dereje , Lemma Legese 
Published: June 2023

Abstract
Background: Intimate partner violence is one of the most common forms of violence against women and includes physical, sexual and emotional abuse and controlling behaviors by an intimate partner.
Objective: To assess prevalence and determinants of intimate partner violence among ANC attendees in Adama Hospital Medical College in Adama, Shewa, Ethiopia.
Methods: Institution based cross sectional study design was conducted from January 01, 2022 to March 15; 2022.A total of 409 pregnant women attending ANC at Adama Hospital Medical College was included in the study by systematic random sampling technique. Data were collected using structured interview-administered questionnaire. Then data were entered and analyzed by SPSS version 22. Binary and multiple logistic regression analysis were done to identify factors associated with intimate partner violence at a p-value of less than 0.05 were considered to declare significance of association.
Result: The overall prevalence of intimate partner violence during current pregnancy was 167 (40.8%) (95%CI: 36.2–45.7). Psychological/emotional violence (39.9%) was the most common followed by sexual (34.7%), Economic violence (34.7%), Physical (23.2%) and controlling behavior violence (22.4%). The proportion of overlap in all five type of violence accounts 28(6.8%), overlap in three (physical, sexual and psychological violence) were 72(17.6%) and overlap in two commonest sexual and psychological violence accounts 115(28.1%). (Among several possible factors: age of women above years 36 years [AOR]: 1.9(1.05, 3.392)], Being rural residence [AOR]: 5.5(2.96, 10.02)], partner Having another partner or wife [AOR]: 3.4(1.64, 7.1)] and undesired pregnancy [AOR]:13.7(5.79, 32.3)] were determinants of IPV.
Conclusion and Recommendation: This study determined intimate partner violence was high (40.8%) and also this study identified that overlap by at least two types violence among these population were 28.1%.Among several possible factors: being rural residence, partner having another partner or wife and undesired pregnancy were determinants of IPV.Therefore; Addressing gender inequitable norms, the culture of silence (support) to IPV in the community and women’s reproductive health information through intervention measures are very important to minimize the problem.
A comprehensive analysis of the co-pathogenesis of atrial fibrillation and atherosclerosis based on bioinformatics
Authors: li han , Zhong Guo-Qiang 
Published: June 2023

Abstract
Background: Atrial fibrillation (AF) is closely related to atherosclerosis (AS), but the common mechanism of the two remains unclear, This study aims to further explore the common hub genes and molecular pathways, to elucidate the common mechanisms of AF and AS.
Methods: AF (GSE41177) and AS (GSE28829) data sets were downloaded from the gene expression Synthesis (GEO) database to search for the co-expressed differential genes (EDGs) of AF and AS, and to analyze the enrichment function of common DEGs. The protein-protein Interaction (PPI) network was created using the (STRING) database with Cytoscape software, and the plug-in cytoHubba was used to select hub genes. The central gene was verified in GSE14905 (AF) and GSE100927 (AS), and the enrichment function of the hub gene was analyzed. In four data sets, GSE41177, GSE28829, GSE14905, and GSE100927, subject manipulation characteristic curves were used to evaluate the availability of hub genes.
Results: A total of 42 common DEGs (37 up-regulated genes and 5 down-regulated genes) were selected for analysis. The PPI network was constructed, and 15 key genes of PPI were identified through cytoHubba, and 9 key genes were finally verified, namely NCF2, C1QC, ITGB2, HLA-DRA, TYROBP, VSIG4, FCER1G, LAPTM5, and C1QB. Finally, the ROC curve was used to verify the effectiveness of key genes. In the result table, 9 hub genes had strong diagnostic values.
Conclusions: In our study, we conducted gene differential expression analysis, functional enrichment analysis, and PPI analysis for DEGs in AF and AS, identified key genes in AF and AS, provided potential biomarkers for the identification of AF and AS, revealed the common pathogenesis of AF and AS, and provided new ideas for the treatment of AF combined with AS.
Six minor allele variants in the TERT-CLPTM1L region are associated with lung cancer risk: a meta-analysis based on different ethnicities and different lung cancer subtypes
Authors: Wu Xiaozheng , Li Wen , Luo Zhenliang , Chen Yunzhi 
Published: June 2023

Abstract
Background: Although many genome-wide association studies(GWAS) have confirmed the associations between multiple sites in the TERT-CLPTM1L region and lung cancer(LC) susceptibility in different populations, some of them haven’t found the associations between these sites and LC. The purpose of this study is to clarify the associations between TERT-CLPTM1L polymorphism and LC, as well as the differences in these associations between patients of different ethnicities and different LC subtypes.
Methods: Relevant literatures published before May 7, 2022 on ‘TERT-CLPTM1L polymorphisms and LC susceptibility’ in PubMed, EMbase,Web of Science, MEDLINE databases were searched through the Internet. Statistical analysis of data was performed in Revman5.3 software, including drawing forest plots, funnel plots and so on. Sensitivity and publication bias analysis were performed in Stata 14.0 software. TSA 0.9.5.10 software was performed for the Trial sequential analysis(TSA) tests to evaluate the stability of the results. Registration number: CRD42023407890.
Results: A total of 51 literatures were included in this meta-analysis, including 6 TERT-CLPTM1L polymorphisms and a total of 54 studies (12 GWAS and 42 case-control studies), including 11 studies in Caucasians and 43 studies in Asians.
The results showed that the minor allele variants of the 6 polymorphisms were positively or negatively associated with the risk of LC (rs2736098[T]: [OR]=1.24, 95% CI [1.18, 1.31]; rs2736100[C]: [OR]=1.25, 95% CI [1.20, 1.30]; rs31489[A]: [OR]=0.87, 95% CI [0.82, 0.92]; rs401681[T]: [OR]=0.87, 95% CI [0.84, 0.90]; rs402710[T]: [OR]=0.86, 95% CI [0.83, 0.88]; rs4975616[G]: [OR]=0.86, 95% CI [0.82, 0.91]). However, there were clear differences in these associations in LC with different pathological subtypes in Caucasian and Asian populations (Subgroup differences: I2≥50%).
Conclusions: Our results confirmed the clear associations between 6 TERT-CLPTM1L polymorphisms and the risk of LC, and there were significant differences in these associations among different ethnicities/pathological subtypes of LC.
VOC investigation factors in the rainforest
Authors: müntz robert 
Published: June 2023

Abstract
So far, numerous VOC research studies have been undertaken on orchids to gain a deeper understanding of their propagation mechanisms. Analyses can be carried out in the laboratory under ideal conditions; external influences of the ambient atmosphere can thus be excluded.
For extensive field studies on the orchid population of an area, samples must be taken directly at the specimen site. As a result, VOCs in the ambient air are considered a matrix when evaluating the results.
VOCs in the ambient air must be considered when evaluating the results; a display of the VOCs in a matrix is usually used for this purpose.
Plant components, in particular higher molecular weight plant waxes (C 28 - C 35), are degraded by microorganisms and UV radiation and are found in the forest air as VOCs (alkanes, aldehydes, and ketones).
By developing a “scentor” (scent collector) with a closed system, both the sensitivity of the detection limit and the exclusion of the surrounding scents can be achieved.
Most of the VOCs found are monoterpenes, followed by sesquiterpenes and to a lesser extent terpenoids, i.e., terpene structures with functional groups. The ubiquitous components of the air (alkanes, aldehydes, and ketones) occurring in outdoor measurements originate from the microbial degradation of higher molecular weight plant waxes (C 28 - C 35) and were taken into account in the evaluation.
Effect of Saline-alkali Stress on Seed Germination of the Halophyte Halostachys caspica
Authors: Zhang Rui , zhang Huizhen , wang lai , Zeng Youling 
Published: June 2023

Abstract
The process of soil salinization and the preponderance of saline water sources all over the world represent one of the most harmful abiotic stresses to plant growth. In nature, soil salt and alkali coexist, and the interaction of salt and alkali is an important feature of saline-alkali stress. Halostachys caspica is a salt-tolerant halophyte belonging to Amaranthaceae and widely distributed in arid and saline-alkali areas in Xinjiang, Northwest China. This paper studied the response of the germination of the desert halophyte Halostachys caspica to different types of salt stress, aiming to provide a theoretical basis for development and utilization of halophytes growing in saline-alkali soils. The results showed that the seed germination of Halostachys caspica was not significantly inhibited when the salt concentration was low (≤ 200 mmol/L), but with the increase of salt concentration, the germination rate of seeds dropped sharply, and the recovery germination rate at high concentration was higher than that at low concentration, when salt was removed. Step-by-step regression analysis showed that at the same concentration, the alkaline salt inhibited seed germination more severely than the neutral salts; the inhibitory effect of the mixed salt and mixed alkali on seed germination is heavier than that of the mono-salt and mono-alkali; under mixed salt alkali stress, the higher the alkaline salt content, the higher the degree of inhibition on seed germination; indicating that alkaline salt play a major role in mixed saline-alkali stress.
Driving gut microbiota enterotypes through host genetics
Authors: Rogel-Gaillard Claire , Larzul Catherine , Estellé Jordi , Borey Marion , Blanc Fany , Lemonnier Gaëtan , Jardet Deborah , Lecardonnel Jérôme , Billon Yvon , Thiam Mamadou-Gabou , Oñate Florian Plaza , Quinquis Benoit , Galleron Nathalie 
Published: June 2023

Abstract
Population stratification based on interindividual variability in gut microbiota composition revealed the existence of several configurations named enterotypes. Enterotypes are often associated with environmental factors whereas the potential impact of host genetics is debated. To explore the genetic determinism of host-microbiota interactions, we established two divergent pig lines with gut microbiota selected for genera pairs specifying two enterotypes (Prevotella and Mitsuokella, or Ruminococcusand Treponema). Per line, relative abundances of directly and indirectly selected genera increased, demonstrating that host genetics influences gut microbiota composition and enterotype prevalence over generations. Metagenomics illustrated different functional potentials between enterotypes and their effects on animal growth. Our work paves the way for a holistic use of host genetics, microbiota diversity and enterotype functionalities in understanding holobiont shaping and adaptation.
GenoBaits®WheatplusEE: a targeted capture sequencing panel for quick and accurate identification of wheat-Thinopyrum derivatives
Authors: Deng Pingchuan , Du Xin , Wang Yanzhen , Yang Xiaoying , Cheng Xiaofang , Huang Chenxi , Li Tingting , Li Tingdong , Chen Chunhuan , Zhao Jixin , Wang Changyou , Liu Xinlun , Tian Zengrong , Ji Wanquan 
Published: June 2023

Abstract
Thinopyrum species are an important source for new genetic variation for wheat improvement because they carry many agronomically important traits, such as abiotic/biotic resistances. Accurate identification of exogenous chromosome(s) or chromosome segments or genes is very important after alien genetic material has been successfully introduced into wheat, but remains challenging. Here, we report the development of a high-resolution wheat-Thinopyrum elongatum array, named GenoBaits®WheatplusEE, to trace alien genetic information through genotyping with a target sequencing system and a liquid chip. A total of 90000 capture probes derived from two species were integrated into one chip, including 10000 and 80000 within wheat and Th. elongatum, respectively. The capture probes were designed to be preferentially located in genes and evenly distributed across the genome, supporting the development of a roadmap guiding each alien genes. The array was applied to high-throughput identification of the alien chromosomes or segments in Thinopyrum and distantly related species, as well as derivatives. Our results validated that the GenoBaits®WheatplusEE array could direct identification of the breakpoint for the alien segment, the alien chromosome copy number, and the wheat chromosome variation by target sequencing the sample only once. Additionally, we can efficiently and cost-effectively genotype, supporting the exploration of subgenome composition, phylogenetic relationships, and important gene (e.g., Fhb7 gene) polymorphisms among Thinopyrum species and derivates. We expect GenoBaits®WheatplusEE to become a popular tool or model that empowers future exploration of the wild germplasm for wheat improvement.
GHP-MOFassemble: Diffusion modeling, high throughput screening, and molecular dynamics for rational discovery of novel metal-organic frameworks for carbon capture at scale
Authors: Huerta Eliu , Park Hyun , Yan Xiaoli , Zhu Ruijie , Chaudhuri Santanu , Cooper Donald , Foster Ian , Tajkhorshid Emad 
Published: June 2023

Abstract
We introduce GHP-MOFassemble, a Generative
artificial intelligence (AI), High Performance framework to accelerate the
rational discovery of metal-organic frameworks
(MOFs) with high CO2 capacity and synthesizable linkers. We combine a diffusion model, a class of generative AI, to generate
novel linkers that are assembled with one of three
pre-selected nodes into MOFs in a primitive cubic (pcu) topology. The CO2 capacities of these AI-generated MOFs are predicted using a modified version
of the crystal graph convolutional neural network model.
We then use the LAMMPS code to perform molecular
dynamics simulations to identify AI-generated MOF structures that converge to stable structures, and maintain their
porous properties throughout the simulations.
Among 120,000 pcu MOF candidates generated by GHP-MOFassemble, with three distinct metal
nodes (Cu paddlewheel, Zn paddlewheel, Zn tetramer), a total of 102 structures completed molecular dynamics simulations at 1bar with predicted CO2
capacity higher than 2mmol/g at 0.1 bar, which corresponds to the top 5% of hMOF in the hypothetical MOF (hMOF) dataset in the MOFX-DB database. Among these candidates, 18 have change in density lower than 1% during molecular dynamics simulations, indicating their stability. The
top five GHP-MOFassemble's MOFs have CO2 capacities higher than 96.9% of hMOF structures.
Beneficiaries’ Satisfaction with Community-Based Health Insurance Services and Associated Factors in Ethiopia: A Systematic Review and Meta-Analysis
Authors: Bayked Ewunetie Mekashaw , Toleha Husien Nurahmed , Zewdie Segenet , Mekonen Asnakew Molla , Workneh Birhanu Demeke , Kahissay Mesfin Haile 
Published: June 2023

Abstract

Background
The viability of community-based health insurance programs depends on beneficiary satisfaction, and healthcare systems evaluate performance through patient reports and ratings to ensure effectiveness and service quality. To our knowledge, Ethiopia lacks national pooled data on the satisfaction of community-based health insurance beneficiaries and related factors; this review aims to address that gap.
Methods
Database searches on Scopus, Hinari, PubMed, Google Scholar, and Semantic Scholar were conducted on September 1st, 2022. Thirteen studies were chosen for review from the search results. Checklists from the Joan Briggs Institute were used to evaluate the risk of bias for the included studies. The data were extracted using a 2019 Microsoft Excel spreadsheet and analyzed using RevMan-5 software and STATA 17. The odds ratios at p-values less than 0.05 with a 95% confidence interval were used to evaluate the effect estimates.
Results
The pooled satisfaction of beneficiaries with community-based health insurance was found to be 66.0% (95% CI = 0.57–0.76) and was found to be influenced by socio-demographic, health service-related, the scheme’s related factors, and the beneficiaries' knowledge of it. The beneficiary satisfaction levels were highest in the Amhara region, at 69.0% (95% CI = 0.59–0.79), followed by SNNPR at 67.0% (95% CI = 0.40–0.94), Oromia at 63.0% (95% CI = 0.58–0.68), and Addis Ababa at 53.0% (95% CI = 0.45–0.62).
Conclusion
Even though there was a moderate level of satisfaction, there are indications that the quality of health services and the coverage of the entire population lag behind, necessitating greater efforts to achieve universal health coverage.
Parameter Optimization of the MQL Nozzle by the Computational Fluid Dynamics
Authors: Yan Lan , Luo Kunhui , Jiang Tao , Xie Hong , Li Yousheng , Xiang Zhiyang , Jiang Feng 
Published: June 2023

Abstract
Minimum quantity lubrication (MQL) has achieved a good effect in precision machining. The geometric parameter of the nozzle has an important effect on the performance of MQL. In order to improve and optimize the performance of MQL, the orthogonal experimental method was adopted in this paper, and ANSYS Fluent software was used to carry out the computational fluid dynamics (CFD) simulation and the simulation data were statistically analyzed. The effects of six influencing factors (i.e. width of gas-phase narrow flow region, taper, output tube length, length of gas-phase narrow flow region, output aperture and pressure) on the performance of MQL were studied. The results showed that the primary and secondary order of the six influencing factors was different under different evaluation criteria. The most important parameter affecting the composite index was the absolute gas velocity at 0.1m away from the outlet. The optimal combination of the geometric parameters of the nozzle was output aperture of 2 mm, taper of 40 degrees, length of gas-phase narrow flow region of 1.5 mm, width of gas-phase narrow flow region of 0.3 mm, output tube length of 15.5 mm, and pressure of 5 bar.