bluuebunny/crossref_metadata_2025_split huggingface dataset:
Updates in the treatment of mantle cell lymphoma: A Canadian expert framework
Authors: Villa Diego , Kansara Roopesh , Lemieux Christopher , Kuruvilla John 
Published: July 2023

Mantle cell lymphoma (MCL) is a B cell Non-Hodgkin Lymphoma that develops in the mantle zone of the lymph node. It is more common in men and is usually diagnosed at an advanced stage with involvement of lymph nodes, bone marrow, and potentially the gastrointestinal tract. MCL accounts for 5–10% of all new NHL cases per year in Canada, which is estimated at 11,400 for 2022. While most patients respond to initial treatment, relapses occur early and MCL generally shows a variable response to subsequent treatments, often with limited duration of benefit. Two main subtypes of MCL can be distinguished that arise from in situ MCL lesions. The most common subtype, classic MCL, arises from these cells with limited or no immunoglobulin heavy chain variable region (IGHV) mutations. Cells from this subtype express SOX11, are genetically unstable, and have naïve B cell-like characteristics. Classic MCL is more often nodal and extranodal and may eventually progress to aggressive blastoid or pleomorphic MCL. The other subtype, leukemic non-nodal MCL, arises from cells that have undergone IGHV somatic hypermutations, do not express SOX11, and exhibit characteristics of memory B cells. This subtype can have an indolent clinical behavior for a long time, often several years, but frequently acquires TP53 and other mutations and progresses to a more aggressive subtype. Treatment options have expanded significantly over the past decades, with improvements in both overall survival (OS) and progression-free survival (PFS) compared to earlier treatment eras. This Canadian expert framework aims to discuss the management considerations for patients with MCL, and will present both front-line treatment options as well as those for relapsed and refractory disease.
A review of the mechanism of action, safety, and efficacy of selinexor in multiple myeloma
Authors: Chen Christine , Neri Paola 
Published: July 2023

In recent years, the armamentarium of routinely available treatments for relapsed and/or refractory multiple myeloma (RRMM) in Canada has dramatically expanded, but treatment gaps still exist. In early relapse (1-3 prior lines), monoclonal antibody (mAb) combinations on a backbone of lenalidomide or bortezomib (e.g. DRd, DVd) have been the mainstay, with combinations building on second generation backbones such as pomalidomide and carfilzomib (e.g. PCd, PVd, Kd) largely reserved for later relapse (after 2 prior lines). However, the increasing use of multi-class drug combinations in the frontline (e.g. DRd, RVd) and a shift towards ongoing therapy until progression, renders patients heavily drug-exposed and refractory at time of early relapse, needful of treatments with novel mechanisms of action. Selinexor is poised to fill an unmet need with a unique, non-overlapping mechanism of action to other available agents. XPOVIO® (selinexor) is indicated in combination with bortezomib and dexamethasone for the treatment of adult patients with multiple myeloma who have received at least one prior therapy. SVd received Health Canada approval May 31, 2022. This review will present data on selinexor’s mechanism of action, efficacy in combination with dexamethasone and bortezomib (Sd, SVd), dosing and scheduling, as well as the management of its common and distinct toxicities.
STUDI DEVIASI PENERAPAN ASPEK HUKUM PENGADAAN KONSTRUKSI
Authors: Erdin Fahlefi  , Akhmad Suraji  , Albani Musyafa  
Published: July 2023

In construction procurement in Indonesia there are still deviations in the tender process. The deviation is caused by an opportunity during the construction bidding process. The service providers are mutually looking for opportunities to seek personal or group benefits or from the working group that makes these deviations. This causes state losses due to deviations in the construction bidding process. This research was conducted by collecting data from institutions that have the authority to decide whether or not deviations occur in the auction process. The institution authorized to decide whether or not a deviation occurs is the Commission for the Supervision of Business Competition of the Republic of Indonesia (KPPU RI). This study uses a questionnaire to find out how much the causes and impacts on state losses are caused by deviations in the auction process and uses the Probability and Impact Matrix method to determine the level of implication values of the causes and impacts of deviations in each case using a case base analysis approach. The results obtained based on the decision are as many as 12 types of deviation based on the case decision. The impact of deviations that occur in construction procurement is material and immaterial losses. The causes of deviation in construction procurement are caused by four factors, namely the factor of wanting to obtain personal or group benefits, opportunities, pressure and business climate. The most contributing factor to the occurrence of deviation is the combined conspiracy and vertical conspiracy resulting in a value of 11.38%.
PEMANFAATAN E-COMMERCE DALAM PENGEMBANGAN UMKM KERAJINAN TENUN GEDOGAN PERSPEKTIF EKONOMI ISLAM DI KECAMATAN PRINGGASELA
Authors: Vianti Rinda Astri , Ro’is Ihsan , Singandaru Adhitya Bagus 
Published: July 2023

Penelitian ini bertujuan untuk mengetahui Pemanfaatan e-commerce dalam Pengembangan Usaha Mikro Kecil dan Menengah (UMKM) Kerajinan Tenun Gedogan di Kecamatan Pringgasela dalam Perspektif Ekonomi Islam. Penelitian ini menggunakan pendekatan kualitatif dengan metode studi kasus. Teknik pengumpulan data yang digunakan adalah teknik wawancara secara mendalam, dokumentasi, dan observasi. Pengumpulan data dan penentuan informan penelitian menggunakan teknik purposive dan snowball. Sumber data penelitian yaitu menggunakan data primer dan data sekunder. Pemeriksaan atau validasi data menggunakan teknik triangulasi yaitu triangulasi sumber dan triangulasi metode.
Hasil penelitian ini menunjukan bahwa pemanfaatan e-commerce dalam pengembangan UMKM di Kecamatan Pringgasela cukup maksimal, hal tersebut dibuktikan dengan adanya upaya pemanfaatan media digital berupa e-commerce dalam pengembangan usaha. Penelitian ini juga menunjukan bahwa pemanfaatan e-commerce dalam pengembangan UMKM tenun Gedogan dalam perspektif ekonomi islam sudah mampu dicerminkan oleh pelaku UMKM tenun Gedogan di Kecamatan Pringgasela.
Pengaruh Pertumbuhan Ekonomi dan Kesempatan Kerja terhadap Indeks Pembangunan Manusia di Kota Palangka Raya 2017-2022
Authors: Suherman  , Nurhidayat Ahmad Fauzi , Sutrisno Feby Adila Indria , Sutrisno Depy Rizkika Indria , Astuti Devi , Maha Egi Ispreidi 
Published: July 2023

Sejauh ini pelaksanaan pembangunan yang dilakukan oleh pemerintah di Indonesia seringkali kurang bahkan tidak sesuai dengan kebutuhan masyarakat pada umumnya. Pola pembangunan yang dilaksanakan pemerintah kurang memeperhatikan kebutuhan masyarakat sehingga bisa menimbulkan kesejahteraan masyarakat didaerah terjadi penurunan, hal tersebut dilihat dari besar ataupun kecilnya IPM dimana hal ini menjadi langkah pemerintah untuk melaksanakan pembangunan masyarakat yang tujuannya agar memiliki lebih banyak opsi, khususnya dalam menjalankan aktivitas ekonomi.
Penelitian ini menerapkan pendekatan kuantitatif yaitu mengumpulkan data sekunder berupa informasi time series dari tahun 2017 - 2022. Regresi linier berganda digunakan dengan perangkat lunak analisis data. Penelitiian ini bertujuan menentukan kontribusi variabel pertumbuhan ekonomi dan kesempatan kerja dalam menentukan variabel yang berpengaruh dalam menentukan indeks pembangunan manusia.
Besaran pengaruh variabel secara Bersama-sama (simultan) dari kedua variabel independen yang memiliki koefisien determinasi sebesar 0,79 (R-Square). Selain itu, hasil dari beberapa analisis menggambarkan variabel X1 (pertumbuhan ekonomi) mempunyai dampak paling negatif terhadap pembangunan manusia. Disimpulkan kesempatan kerja (variabel X2) memiliki pengaruh positif dan signifikan secara statistik terhadap IPM jika nilai koefisiennya 0,729 dan probabilitasnya < 0,05 yaitu 0,047.
CONTAMINANT IDENTIFICATION IN WATER BY MICROBIAL BIOSENSORS
Authors: Islam Mafiqul , Rana Md. Shohel 
Published: July 2023

The various micro-organisms are used to identify contaminated water. By the help of biosensors, drinking water pollution can be estimated. Rising environmental pollution is badly affecting water. Drinking contaminated water causes serious diseases in human beings as well as in animals.
Microorganism in contaminated water can spread serious diseases. Biosensors are genetically modified to identify the occurrence of heavy metals, chemicals and toxins in contaminated water. Different microbes are used as biosensors such as Escherichia coli, Algae, Fungi and Clostridium etc. All these biosensors help to detect water pollution by different ways. For example, algae can detect water contamination by fluorescence during photosynthesis. Most rural areas are being affected by contaminated water. Most of the people living in rural areas are being affected by the polluted water as clean water is not available in these areas. People living in rural areas use water that looks clear but contains micro-pathogens that can cause dangerous diseases. Biosensors are important for identifying contamination, Due biosensor, can easily deduct pollution. Water is very important for the survival.
Drinking contaminated water can cause serious illness. Therefore, clean water is very important.
Current trends of library automation Academic library in Bangladesh
Authors: Islam Mafiqul 
Published: July 2023

This research focuses on current trends of library automation in Rajshahi University Central Library. This research try to find out RUCL various work sections and services present status. The work is confined on one university library in Bangladesh. It try to investigate on different aspects and function. Finally the work find out some problems and suggestions on rajshahi university central library automation system.
This study provides a bird’s eye on automation system rajshahi university central library view but don’t give a total idea on library automation system in Bangladesh
Electrochemical Processes for the Formation of Hydroxyapatite Powders
Authors: Nur Adrian , Setyawan Heru , Widjaja Arief , Lenggoro I. Wuled 
Published: July 2023

Electrochemical synthesis of hydroxyapatite particles was performed from a homogeneous solution of Na2H2EDTA.2H2O, KH2PO4 and CaCl2 without stirring to investigate the mechanism of hydroxyapa-tite formation. We found that OH- ions generated by water reduction at the cathode play an important role in the formation of hydroxyapatite particles. The OH- ions induce the liberation of Ca2+ ions and the dissociation of phosphoric acid, which serve as the reactants for the formation of hydroxyapatite particles. Two layers with a clear boundary were formed during electrolysis. The upper layer comprises the produced particles and the lower layer is a homogeneous solution. The produced particles were held in the region between the electrodes mainly due to the electrostatic interactions of charged particles in an electric field. The hydroxyapatite particles are agglomerates consisting of spherical particles. Aging the suspension for 24 h after electrolysis leads to the transformation of hydroxyapatite to brushite. Thus, if producing hydroxyapatite is desired, the particles should be continuously removed from the system. This method appears to be promising as a continuous process to produce hydroxyapatite parti-cles using an electrochemical method. © 2014 by Authors, Published by BCREC Group. This is an open access article under the CC BY-SA License (https://creativecommons.org/licenses/by-sa/4.0)
Water Adsorption in MOFs: Structures and Applications
Authors: Zhang Bo , Zhu Zerui , Wang Xuerui , Liu Xinlei , Kapteijn Freek 
Published: July 2023

AbstractMetal–organic frameworks (MOFs) are superior sorbents for water adsorption‐based applications. The unique step‐like water isotherm at a MOF‐specific relative pressure allows easy loading and regeneration over a small range of temperature and pressure conditions. With good hydrothermal stability and cyclic durability, it stands out over classical sorbents used in applications for humidity control, water harvesting, and adsorption‐based heating and cooling. These are easily regenerated at moderate temperatures using “waste” heat or solar heating. The isotherm thermodynamics and adsorption mechanisms are described, and the presence of MOFs in the water–air system is explained. Based on six selection criteria ≈40 reported MOFs and one COF are identified for potential application. Trends and approaches in further synthesis optimization and production scale‐up are highlighted. No‐MOF‐fits‐all, each MOF has its own specific step location matching only with a certain application type. Most applications are technically feasible and demonstrated on the bench‐scale or small pilot. Their maturity is benchmarked by their technology readiness level. Retrofitting existing applications with MOFs replacing classical desiccants may lead to rapid demonstration. Studies on techno‐economic analysis and life cycle analysis are required for a rational evaluation of the feasibility of promising applications.
Mechano‐Driven Tribo‐Electrophoresis Enabled Human–Droplet Interaction in 3D Space
Authors: Sun Jianfeng , Zhang Lingjun , Gong Siqi , Chen Jie , Guo Hengyu 
Published: July 2023

AbstractElectronically controlled droplet manipulation has widespread applications in biochemistry, life sciences, and industry. However, current technologies such as electrowetting, electrostatics, and surface charge printing rely on complex electrode arrays and external power supplies, leading to inefficient manipulation. In light of these limitations, a novel method is proposed, which leverages tribo‐electrophoresis (TEP) to pipette in an oil medium, thereby enabling human–droplet interactions to be constructed with greater efficiency. The approach involves the rational design of a triboelectric nanogenerator–electrostatic tweezer that generates an electric field to charge the droplet and improves the maneuverability of the charged droplet, including aligned/non‐aligned pipetting and stable transport in the clamped state, which can be accomplished solely by hand motion. The TEP method not only provides droplets with freedom to move in three dimensions but also offers a feasibility case for chemical reactions in the liquid phase and non‐invasive sample extraction. This breakthrough establishes a cornerstone for human–droplet interactions capitalized on triboelectric nanogenerators, opening new avenues for research in droplet manipulation.
Intramolecular Hydrogen Bonding Enables a Zwitterionic Mechanism for Macrocyclic Peptide Formation: Computational Mechanistic Studies of CyClick Chemistry
Authors: Shao Huiling , Adebomi Victor , Bruce Angele , Raj Monika , Houk Kendall N. 
Published: July 2023

AbstractMacrocyclic peptides have become increasingly important in the pharmaceutical industry. We present a detailed computational investigation of the reaction mechanism of the recently developed “CyClick” chemistry to selectively form imidazolidinone cyclic peptides from linear peptide aldehydes, without using catalysts or directing groups (Angew. Chem. Int. Ed. 2019, 58, 19073–19080). We conducted computational mechanistic to investigate the effects of intramolecular hydrogen bonds (IMHBs) in promoting a kinetically facile zwitterionic mechanism in “CyClick” of pentapeptide aldehyde AFGPA. Our DFT calculations highlighted the importance of IMHB in pre‐organization of the resting state, stabilization of the zwitterion intermediate, and the control of the product stereoselectivity. Furthermore, we have also identified that the low ring strain energy promotes the “CyClick” of hexapeptide aldehyde AAGPFA to form a thermodynamically more stable 15+5 imidazolidinone cyclic peptide product. In contrast, large ring strain energy suppresses “CyClick” reactivity of tetra peptide aldehyde AFPA from forming the 9+5 imidazolidinone cyclic peptide product.
Strategic Synthesis of Heptacoordinated FeIII Bifunctional Complexes for Efficient Water Electrolysis
Authors: Chatterjee Abhishikta , Mondal Papri , Chakraborty Priyanka , Kumar Bidyapati , Mandal Sourav , Rizzoli Corrado , Saha Rajat , Adhikary Bibhutosh , Dey Subrata K. 
Published: July 2023

AbstractIn this research, highly efficient heterogeneous bifunctional (BF) electrocatalysts (ECs) have been strategically designed by Fe coordination (CR) complexes, [Fe2L2(H2O)2Cl2] (C1) and [Fe2L2(H2O)2(SO4)].2(CH4O) (C2) where the high seven CR number synergistically modifies the electronic environment of the Fe centre for facilitation of H2O electrolysis. The electronic status of Fe and its adjacent atomic sites have been further modified by the replacement of −Cl− in C1 by −SO42− in C2. Interestingly, compared to C1, the O−S−O bridged C2 reveals superior BF activity with extremely low overpotential (η) at 10 mA cm−2 (140 mVOER, 62 mVHER) and small Tafel slope (120.9 mV dec−1OER, 45.8 mV dec−1HER). Additionally, C2 also facilitates a high‐performance alkaline H2O electrolyzer with cell voltage of 1.54 V at 10 mA cm−2 and exhibits remarkable long‐term stability. Thus, exploration of the intrinsic properties of metal–organic framework (MOF)‐based ECs opens up a new approach to the rational design of a wide range of molecular catalysts.
Non‐alcohol substance use disorder after bariatric surgery in the prospective, controlled Swedish Obese Subjects study
Authors: Svensson Per‐Arne , Peltonen Markku , Andersson‐Assarsson Johanna C. , Ahlin Sofie , Brembeck Petra , Engström My , Jacobson Peter , Taube Magdalena , Sjöholm Kajsa , Carlsson Lena M. S. 
Published: July 2023

AbstractObjectiveThe goal of this study was to investigate whether bariatric surgery is associated with substance use disorder (SUD) with substances other than alcohol.MethodsThe prospective, controlled Swedish Obese Subjects study enrolled 2010 patients with obesity who underwent bariatric surgery (gastric bypass n = 265; vertical banded gastroplasty n = 1369; gastric banding n = 376) and 2037 matched control individuals receiving usual obesity care. Participants with SUD other than alcohol use disorder were identified using International Statistical Classification of Diseases (ICD) codes from the Swedish National Patient Register (covering treatment in hospital but not primary care). Those with a history of non‐alcohol SUD were excluded. Median follow‐up was 23.8 years.ResultsDuring follow‐up, non‐alcohol SUD incidence rates per 1000 person‐years with 95% CI were 1.6 (0.8–3.1), 0.8 (0.5–1.2), 1.1 (0.5–2.2), and 0.6 (0.4–0.8) for gastric bypass, vertical banded gastroplasty, gastric banding, and control individuals, respectively. Only gastric bypass was associated with increased incidence of non‐alcohol SUD (adjusted hazard ratio 2.54 [95% CI: 1.14‐5.65], p = 0.022) compared with control participants.ConclusionsGastric bypass surgery was associated with increased risk of non‐alcohol SUD, and this should be considered in long‐term postoperative care.
Telehealth use in Australian cystic fibrosis centers: Clinician experiences
Authors: Shanthikumar Shivanthan , Ruseckaite Rasa , Corda Jen , Mulrennan Siobhain , Ranganathan Sarath , Douglas Tonia 
Published: July 2023

AbstractBackgroundTelehealth has been rapidly adopted by cystic fibrosis (CF) centers and ongoing use in routine CF care is endorsed by CF consumers. However, data describing CF clinician perceptions regarding telehealth are scarce. We aimed to describe clinician experiences and attitudes towards telehealth in CF care among health professionals across Australia.MethodsCF multidisciplinary health professionals from all CF clinics in Australia were sent an anonymous electronic survey.ResultsEighty‐five responses were received representing 15 of 23 (65%) centers. Most clinicians reported using telehealth for routine clinic visits, and a range of other clinical encounters (69.9%). Telehealth was widely perceived as acceptable (91.8%), and clinicians were comfortable/very comfortable (81.2%) integrating telehealth into future CF care. Despite this, 64.1% of respondents considered telehealth clinics to be much worse than face‐to‐face clinics and 57.5% reported quality of care was somewhat/much worse using telehealth. Home spirometry was available in 73.7% of centers, however, only 26.7% of clinics could provide spirometers for >75% eligible patients. Growth and microbiology assessments were often missed in telehealth clinics and 75.7% reported a technical issue had prevented a telehealth consultation from occurring.ConclusionsTelehealth for CF in Australia is considered feasible and acceptable by CF clinicians, although use of telehealth varies widely between centers. Concerns exist around the impact of telehealth on health outcomes, especially given core assessments are frequently omitted. Guidelines may help ensure the benefits of telehealth are realized for people with CF without compromising the standard of care.
Social and Healthcare Impacts of the Russian-Led Hybrid War in Ukraine – A Conflict With Unique Global Consequences
Authors: Khorram-Manesh Amir , Goniewicz Krzysztof , Burkle Frederick M. 
Published: July 2023

AbstractRussia’s fear of Ukraine becoming a member of the European Union and the North Atlantic Treaty Organization catalyzed the current conflict in Ukraine. The invasion also alarmed other countries, such as Finland and Sweden, who have themselves considered a formal partnership with NATO. Russia’s actions to date have created massive instability and political tensions that uniquely influence the health and socio-political life of civilians in Ukraine and the entire region. The direct and indirect threats of war “gone regional,” “global”, or “nuclear” have energized these countries and their historical alliances to reassess their own socio-political, environmental, and health-care consequences. All countries of the region have clear histories of forced occupation and decades of threats resulting from World War II and its aftermath. The purpose of this rapid communication is 2-fold. First, it discusses the socio-political and health-care consequences of the ongoing Ukrainian conflict in Finland, Russia, Sweden, Poland, and Ukraine. Second, it clarifies the most essential elements of the Hybrid War which cause uniquely distinctive violations of humanitarian laws, treaties, and conventions.
Horizontal Wavenumber Spectra Across the Middle Atmosphere From Airborne Lidar Observations During the 2019 Southern Hemispheric SSW
Authors: Knobloch Stefanie , Kaifler Bernd , Dörnbrack Andreas , Rapp Markus 
Published: July 2023

AbstractHorizontal wavenumber spectra across the middle atmosphere are investigated based on density measurements with the Airborne Lidar for Middle Atmosphere research (ALIMA) in the vicinity of the Southern Andes, the Drake passage and the Antarctic peninsula in September 2019. The probed horizontal scales range from 2000 to 25 km. Spectral slopes are close to k−5/3 in the stratosphere and get shallower for horizontal wavelengths <200 km in the mesosphere. The spectral slopes are shown to be statistically robust with the presented number of flight legs despite the unknown orientation of true wave vectors relative to the flight track using synthetic data and a Monte Carlo approach. The largest spectral amplitudes are found over the ocean rather than over topography. The 2019 sudden stratospheric warming caused a critical level for MWs and a reduction of spectral amplitudes at horizontal wavelengths of about 200 km in the mesosphere.