bluuebunny/crossref_metadata_2025_split huggingface dataset:
Peranan Magnetic Resonance Imaging (MRI) Lumbal dalam Penegakan Diagnosis Kasus Low Back Pain: Studi Kasus di Instalasi Radiologi Rumah Sakit Satya Negara Jakarta Utara
Authors: Setiyoningsih Wahyu , Apriantoro Nursama Heru 
Published: September 2023

Background: Magnetic resonance imaging (MRI) is considered the best imaging for chronic low back pain because of high tissue contrast and no effect of ionizing radiation. The purpose of this study was to determine the management of Lumbar MRI examination with Low Back Pain Cases.Methods: The research used was a qualitative descriptive research method by collecting data by direct observation which was conducted in December 2022 at Satya Negara Hospital, North Jakarta. The research was conducted using direct observation methods, documentation and decision studies. The sample used was 1 patient.Results: The image results are strengthened by the expertise of a radiologist. The results of the study were obtained from the beginning of the patient's process of coming to radiology to perform a Lumbar MRI examination in the administration section until the examination was completed. Using a GE 1.5 T MRI machine and a whole spine coil. The sequences used are 3-plane location, calibration scan lumbar, Coronal T2, Sagittal T2, Sagittal T1, Sagittal T2 + FATSAT, Axial T2, Sagittal Myelography, Coronal Myelography.Conclusions: This study shows that Lumbar MRI image results and the doctor's expertise show that there is grade I spondylolithesis and L4-L5 spondyloarthrosis with disc protrusion. It’s mean that MRI can provide information for making a diagnosis.
Karamanoğlu Mehmetbey Üniversitesi’nin 2007-2022 Yılları Arası SCI-Ex, ESCI ve SSCI Alan İndexlerinde Yayınlarının Bibliyometrik Analizi
Authors: BAY Murat , PAYLI Muhammet 
Published: September 2023

Bu çalışmada, 2007-2022 yılları arasında Karamanoğlu Mehmetbey Üniversitesi’nin bibliyometrik analizi yapılmıştır.
Web Of Science-WoSveri tabanından elde edilen veri dosyası 429 makalenin bibliyometrik analizleri gerçekleştirilmiştir. Karamanoğlu Mehmetbey Üniversitesi kapsamında yayınlanan makale çalışmaları yazar, ülke ve üniversiteler arasındaki ilişki bağı analizleri yapılmıştır. Yapılan çalışma neticesinde; KMÜ’de yapılan çalışmaların birçok üniversite, yazar ve ülkeler ile ilişki bağı açısından farklılıkların olduğu tespit edilmiştir. 280 yazar yapmış oldukları çalışmalar ile KMÜ’ye destek vermiştir. Yapılan araştırma çalışmasında, dünyadaki üniversiteler arasında 106 üniversitenin ve dünya ülkeleri arasında ise 36 ülkenin ön plana çıktığı tespit edilmiştir. KMÜ kapsamında yapılan araştırmada; yazarlar açısından en fazla makale, yazarlar arası bağ (ilişki) sayısına ve bu unsurlara bağlı en yüksek bağlantı gücüne sahip olan yazarın Elhatisari, Serdar’ın olduğu tespit edilmiştir. Ülkeler açısından en fazla makale, ülkeler arası bağ (ilişki) sayısına ve bu unsurlara bağlı en yüksek bağlantı gücüne sahip olan ülkenin Türkiye olduğu tespit edilmiştir. KMÜ kapsamında yapılan çalışmada; Web Of Science-WoS veri tabanına ait yayınlanan en fazla makalenin 344 ile fizik (Physics) alanında olduğu, yıl olarak ise en fazla yayınlanan 116 makale çalışmasının 2019 yılında yapılmış olduğu tespit edilmiştir. Alan indeksi açısından ise, en fazla yayınlanan 420 makale çalışmasının Science Citation Index Expanded (SCI-EX) alan indeksinde yapıldığı tespit edilmiştir.
Eskiçağ Yunan Felsefesi ve İbn Haldun’da Coğrafya ve İnsan İlişkisinin İncelenmesi
Authors: KILIÇ Elife 
Published: September 2023

Yeryüzü, çevre veya bulunulan coğrafyanın şartları, insanı ve insan etkinliklerini sürekli etkilemiş ve etkilemeye de devam etmektedir. Çünkü insan gerek fizikî, gerek düşünsel ve ahlâkî olmak üzere birçok yönden bu faktörlere maruz kalmaktadır.
Bu etkiyi yazıya döken düşünürlerin metinlerini inceleyerek, sorunun nasıl ve hangi boyutlarda ele alındığını ve nasıl anlaşıldığını ortaya koymak konuyu daha iyi anlamamızı sağlayacaktır. Özellikle bu sorunu büyük ölçüde çok daha eski tarihlerde inceleyen Eskiçağ Yunan filozofları ve sonrasında İbn Haldun’un görüşlerine bakılacaktır. İnsan ve çevre arasındaki ilişkinin ne olduğu, hangisinin daha ağırlıkta olduğu ve bunun ölçütünün ne olduğu tartışma konusudur. İnsan, doğanın parçası olduğuna göre, insanı dolayısıyla kendimizi daha iyi anlamak için, bu konu büyük önem arz etmektedir. Bu sebeple, makalemizde başlangıçta coğrafyanın ne olduğu, metodu, konusu kısaca incelendikten sonra coğrafyanın temel ilgi alanı olan mekân ve iklimin insanın yapısına, düşüncesine olan etkileri Eskiçağ Yunan dönemi düşünürleri ve İbn Haldun özelinde ele alınacaktır.
Vaginal Cancer: Association with long term use of Pessary in Pelvic Organ Prolapse
Authors: Begum Hamida , Rashid M , Shamima H , Zohra F 
Published: September 2023

Vaginal cancer, rarest form of gynaecological cancer (0.6%) has been found to be associated with long term use of vaginal ring pessary, which have long been used in alternative management of pelvic organ prolapse (POP) other than surgery. A through survey was done in remote areas of Cox’s bazar, refugee camp where out of 52 cases of pelvic organ prolapse, 7 cases found to use vaginal ring pessary for long and out of 7, vaginal cancer developed in 4 cases. All of them were aged women above 60 and had defaulted follow up presented with vaginal bleeding, varying discharge and pain of varying intensity. One patient had only local lesion was treated by surgical removal followed by radiotherapy. The 2 nd one, 68 years, received neo-adjuvant therapy and died before planned surgery. The 3 rd one, aged 79, did not come for follow up after diagnosis of vaginal cancer done and advised for definitive surgical treatment, family refused operation and she passed away after 2 years at 81 years. The 4 th one declined further investigations and any form of treatment once diagnosed with vaginal cancer. So, all patients of pelvic organ prolapse should be informed thoroughly (both verbal and written informed consent) before inserting pessary for potential long term serious consequences where strict compliance must be ensured for subsequent regular follow up and biopsy should be mandatory for any suspicious chronic vaginal ulcers among them.
Bangladesh J Obstet Gynaecol, 2022; Vol. 37(1): 75-77
Etnobotani: Nilai Ekonomi Pemanfaatan Pisang (Musa sp) Berbasis Kearifan Lokal Pada Masyarakat Desa Puundoho Kecamatan Pakue Utara
Authors: Syamsuri Syamsuri , Hastuti Hastuti , Alang Hasria , Hamdani Ibnu Mansyur 
Published: September 2023

Tumbuhan mempunyai beragam manfaat bagi kehidupan manusia sehingga disebut memiliki nilai ekonomi. Salah satu jenis tumbuhan yang banyak dimanfaatkan yaitu Pisang (Musa sp). Kajian nilai ekonomi pisang dapat dimulai dari inventarisasi pemanfaatannya pada suatu suku atau etnis yang disebut etnobotani. Kajian etnobotani merupakan salah satu langkah mendokumentasikan pengetahuan lokal suatu etnis, sehingga mengarah kepada konservasi karena pentingnya peranan dari suatu macam tumbuhan. Tujuan penelitian ini yaitu untuk menginventarisir pemanfaatan pisang bagi masyarakat lokal di Desa Puundoho, sehingga dapat terdokumentasi dengan baik dan akhirnya mengarah kepada salah satu upaya konservasi pisang dan kearifan lokal tetap terjaga diera disrupsi modern saat ini. Metode penelitian ini yaitu melalui observasi, ekplorasi dan wawancara pada informan terpilih. Data hasil penelitian selanjutnya dianalisis secara deskriptif. Hasil penelitian menunjukkan bahwa hampir semua bagian tanaman pisang dimanfaatakan oleh masyarakat. Pemanfaatan tersebut juga didukung oleh data sains terutama karena adanya kandungan senyawa yang terdapat dalam bagian tanaman pisang tersebut. Kesesuaian ini menjadi peluang untuk pengembangan seperti obat dimasa mendatang. Berdasarkan hasil penelitian, maka disimpulkan bahwa bagian tanaman pisang yang digunakan beserta pemanfaatannya yaitu jantung pisang digunakan sebagai lauk atau sayuran, batang semu pisang digunakan sebagai tancapan bambu untuk menyimpan gelas, daun pisang muda digunakan sebagai pembatas dan pembungkus makanan dan kue tradisional, daun pisang kering sebagai pembungkus baje dan gula aren, buah pisang untuk membuat kue-kue tradisional dan sebagai terapi pada penderita susah buang air besar dan ambeiyen, kulit pisang digunakan sebagai pakan ternak kambing..
Targeting the chemokine receptor CXCR4 with histamine analog to reduce inflammation in juvenile arthritis
Authors: Bekaddour Nassima , Smith Nikaïa , Beitz Benoit , Llibre Alba , Dott Tom , Baudry Anne , Korganow Anne-Sophie , Nisole Sébastien , Mouy Richard , Breton Sylvain , Bader-Meunier Brigitte , Duffy Darragh , Terrier Benjamin , Schneider Benoit , Quartier Pierre , Rodero Mathieu P. , Herbeuval Jean-Philippe 
Published: September 2023

IntroductionAmong immune cells, activated monocytes play a detrimental role in chronic and viral-induced inflammatory pathologies, particularly in Juvenile Idiopathic Arthritis (JIA), a childhood rheumatoid arthritis (RA) disease. The uncontrolled activation of monocytes and excessive production of inflammatory factors contribute to the damage of bone-cartilage joints. Despite the moderate beneficial effect of current therapies and clinical trials, there is still a need for alternative strategies targeting monocytes to treat RA.MethodsTo explore such an alternative strategy, we investigated the effects of targeting the CXCR4 receptor using the histamine analog clobenpropit (CB). Monocytes were isolated from the blood and synovial fluids of JIA patients to assess CB's impact on their production of key inflammatory cytokines. Additionally, we administered daily intraperitoneal CB treatment to arthritic mice to evaluate its effects on circulating inflammatory cytokine levels, immune cell infiltrates, joints erosion, and bone resorption, as indicators of disease progression.ResultsOur findings demonstrated that CXCR4 targeting with CB significantly inhibited the spontaneous and induced-production of key inflammatory cytokines by monocytes isolated from JIA patients. Furthermore, CB treatment in a mouse model of collagen-induce arthritis resulted in a significant decrease in circulating inflammatory cytokine levels, immune cell infiltrates, joints erosion, and bone resorption, leading to a reduction in disease progression.DiscussionIn conclusion, targeting CXCR4 with the small amino compound CB shows promise as a therapeutic option for chronic and viral-induced inflammatory diseases, including RA. CB effectively regulated inflammatory cytokine production of monocytes, presenting a potential targeted approach with potential advantages over current therapies. These results warrant further research and clinical trials to explore the full therapeutic potential of targeting CXCR4 with CB-like molecules in the management of various inflammatory diseases.
A hub gene signature as a therapeutic target and biomarker for sepsis and geriatric sepsis-induced ARDS concomitant with COVID-19 infection
Authors: Qian Guojun , Fang Hongwei , Chen Anning , Sun Zhun , Huang Meiying , Luo Mengyuan , Cheng Erdeng , Zhang Shengyi , Wang Xiaokai , Fang Hao 
Published: September 2023

BackgroundCOVID-19 and sepsis represent formidable public health challenges, characterized by incompletely elucidated molecular mechanisms. Elucidating the interplay between COVID-19 and sepsis, particularly in geriatric patients suffering from sepsis-induced acute respiratory distress syndrome (ARDS), is of paramount importance for identifying potential therapeutic interventions to mitigate hospitalization and mortality risks.MethodsWe employed bioinformatics and systems biology approaches to identify hub genes, shared pathways, molecular biomarkers, and candidate therapeutics for managing sepsis and sepsis-induced ARDS in the context of COVID-19 infection, as well as co-existing or sequentially occurring infections. We corroborated these hub genes utilizing murine sepsis-ARDS models and blood samples derived from geriatric patients afflicted by sepsis-induced ARDS.ResultsOur investigation revealed 189 differentially expressed genes (DEGs) shared among COVID-19 and sepsis datasets. We constructed a protein-protein interaction network, unearthing pivotal hub genes and modules. Notably, nine hub genes displayed significant alterations and correlations with critical inflammatory mediators of pulmonary injury in murine septic lungs. Simultaneously, 12 displayed significant changes and correlations with a neutrophil-recruiting chemokine in geriatric patients with sepsis-induced ARDS. Of these, six hub genes (CD247, CD2, CD40LG, KLRB1, LCN2, RETN) showed significant alterations across COVID-19, sepsis, and geriatric sepsis-induced ARDS. Our single-cell RNA sequencing analysis of hub genes across diverse immune cell types furnished insights into disease pathogenesis. Functional analysis underscored the interconnection between sepsis/sepsis-ARDS and COVID-19, enabling us to pinpoint potential therapeutic targets, transcription factor-gene interactions, DEG-microRNA co-regulatory networks, and prospective drug and chemical compound interactions involving hub genes.ConclusionOur investigation offers potential therapeutic targets/biomarkers, sheds light on the immune response in geriatric patients with sepsis-induced ARDS, emphasizes the association between sepsis/sepsis-ARDS and COVID-19, and proposes prospective alternative pathways for targeted therapeutic interventions.
Comparison of different predictive biomarker testing assays for PD-1/PD-L1 checkpoint inhibitors response: a systematic review and network meta-analysis
Authors: Shi Haotong , Zhang Wenxia , Zhang Lin , Zheng Yawen , Dong Taotao 
Published: September 2023

BackgroundAccurate prediction of efficacy of programmed cell death 1 (PD-1)/programmed cell death ligand 1 (PD-L1) checkpoint inhibitors is of critical importance. To address this issue, a network meta-analysis (NMA) comparing existing common measurements for curative effect of PD-1/PD-L1 monotherapy was conducted.MethodsWe searched PubMed, Embase, the Cochrane Library database, and relevant clinical trials to find out studies published before Feb 22, 2023 that use PD-L1 immunohistochemistry (IHC), tumor mutational burden (TMB), gene expression profiling (GEP), microsatellite instability (MSI), multiplex IHC/immunofluorescence (mIHC/IF), other immunohistochemistry and hematoxylin-eosin staining (other IHC&amp;HE) and combined assays to determine objective response rates to anti–PD-1/PD-L1 monotherapy. Study-level data were extracted from the published studies. The primary goal of this study was to evaluate the predictive efficacy and rank these assays mainly by NMA, and the second objective was to compare them in subgroup analyses. Heterogeneity, quality assessment, and result validation were also conducted by meta-analysis.Findings144 diagnostic index tests in 49 studies covering 5322 patients were eligible for inclusion. mIHC/IF exhibited highest sensitivity (0.76, 95% CI: 0.57-0.89), the second diagnostic odds ratio (DOR) (5.09, 95% CI: 1.35-13.90), and the second superiority index (2.86). MSI had highest specificity (0.90, 95% CI: 0.85-0.94), and DOR (6.79, 95% CI: 3.48-11.91), especially in gastrointestinal tumors. Subgroup analyses by tumor types found that mIHC/IF, and other IHC&amp;HE demonstrated high predictive efficacy for non-small cell lung cancer (NSCLC), while PD-L1 IHC and MSI were highly efficacious in predicting the effectiveness in gastrointestinal tumors. When PD-L1 IHC was combined with TMB, the sensitivity (0.89, 95% CI: 0.82-0.94) was noticeably improved revealed by meta-analysis in all studies.InterpretationConsidering statistical results of NMA and clinical applicability, mIHC/IF appeared to have superior performance in predicting response to anti PD-1/PD-L1 therapy. Combined assays could further improve the predictive efficacy. Prospective clinical trials involving a wider range of tumor types are needed to establish a definitive gold standard in future.
12/15-lipoxygenase inhibition attenuates neuroinflammation by suppressing inflammasomes
Authors: Cakir-Aktas Canan , Bodur Ebru , Yemisci Muge , van Leyen Klaus , Karatas Hulya 
Published: September 2023

IntroductionLipoxygenases (LOXs) have essential roles in stroke, atherosclerosis, diabetes, and hypertension. 12/15-LOX inhibition was shown to reduce infarct size and brain edema in the acute phase of experimental stroke. However, the significance of 12/15-LOX on neuroinflammation, which has an essential role in the pathophysiology of stroke, has not been clarified yet.MethodsIn this study, ischemia/recanalization (I/R) was performed by occluding the proximal middle cerebral artery (pMCAo) in mice. Either the 12/15-LOX inhibitor (ML351, 50 mg/kg) or its solvent (DMSO) was injected i.p. at recanalization after 1 h of occlusion. Mice were sacrificed at 6, 24, and 72-h after ischemia induction. Infarct volumes were calculated on Nissl-stained sections. Neurological deficit scoring was used for functional analysis. Lipid peroxidation was determined by the MDA assay, and the inflammatory cytokines IL-6, TNF-alpha, IL-1beta, IL-10, and TGF-beta were quantified by ELISA. The inflammasome proteins NLRP1 and NLRP3, 12/15-LOX, and caspase-1 were detected with immunofluorescence staining.ResultsInfarct volumes, neurological deficit scores, and lipid peroxidation were significantly attenuated in ML351-treated groups at 6, 24, and 72-h. ELISA results revealed that the pro-inflammatory cytokines IL-1beta, IL-6, and TNF-alpha were significantly decreased at 6-h and/or 24-h of I/R, while the anti-inflammatory cytokines IL-10 and TNF-alpha were increased at 24-h or 72-h of ML351 treatment. NLRP1 and NLRP3 immunosignaling were enhanced at three time points after I/R, which were significantly diminished by the ML351 application. Interestingly, NLRP3 immunoreactivity was more pronounced than NLRP1. Hence, we proceeded to study the co-localization of NLRP3 immunoreactivity with 12/15-LOX and caspase-1, which indicated that NLRP3 was co-localized with 12/15-LOX and caspase-1 signaling. Additionally, NLRP3 was found in neurons at all time points but in non-neuronal cells 72 h after I/R.DiscussionThese results suggest that 12/15-LOX inhibition suppresses ischemia-induced inflammation in the acute and subacute phases of stroke via suppressing inflammasome activation. Understanding the mechanisms underlying lipid peroxidation and its associated pathways, like inflammasome activation, may have broader implications for the treatment of stroke and other neurological diseases characterized by neuroinflammation.
Dosimetric and radiobiological comparison between conventional and hypofractionated breast treatment plans using the Halcyon system
Authors: Tai Duong Thanh , Phat Luong Tien , Ngoc Anh Nguyen , Sang Huynh Van Tran , Loc Tran Minh , Hai Nguyen Xuan , Sandwall Peter A. , Bradley David , Chow James C. L. 
Published: September 2023

PurposeThe objective of this research is to compare the efficacy of conventional and hypofractionated radiotherapy treatment plans for breast cancer patients, with a specific focus on the unique features of the Halcyon system.Methods and materialsThe study collected and analyzed dose volume histogram (DVH) data for two groups of treatment plans implemented using the Halcyon system. The first group consisted of 19 patients who received conventional fractionated (CF) treatment with a total dose of 50 Gy in 25 fractions, while the second group comprised 9 patients who received hypofractionated (HF) treatment with a total dose of 42.56 Gy in 16 fractions. The DVH data was used to calculate various parameters, including tumor control probability (TCP), normal tissue complication probability (NTCP), and equivalent uniform dose (EUD), using radiobiological models.ResultsThe results indicated that the CF plan resulted in higher TCP but lower NTCP for the lungs compared to the HF plan. The EUD for the HF plan was approximately 49 Gy (114% of its total dose) while that for the CF plan was around 53 Gy (107% of its total dose).ConclusionsThe analysis suggests that while the CF plan is better at controlling tumors, it is not as effective as the HF plan in minimizing side effects. Additionally, it is suggested that there may be an optimal configuration for the HF plan that can provide the same or higher EUD than the CF plan.
The risk of developing type 2 diabetes mellitus among the students of Hail University, Saudi Arabia
Authors: Abd El-Razik Siam Bahia Glalal , Abdou Rizk Shimaa Mohamed , Mahmoud Soha Kamel Mosbah 
Published: September 2023

BackgroundGlobally, it is estimated that approximately 537 million adults are living with diabetes. Of them, more than 90% have type 2 diabetes (T2DM). In 2023, a previous meta-analysis showed that the prevalence of T2DM among the general adult population in Saudi Arabia was 28%. This study was conducted to assess the risk of developing T2DM among the students at Hail University, Saudi Arabia.MethodsThis cross-sectional study was conducted in 2022/2023 among a census sample of 740 students (both genders, aged 17–26 years) studying at nine colleges of Hail University, Saudi Arabia. The diabetes risk score was assessed using the Australian Type 2 Diabetes Risk Assessment Tool (AUSDRISK). Anthropometric measurements were measured and recorded using standard methods. Socio-demographic variables were also obtained with an interview-based questionnaire. Statistical analysis was performed using SPSS version 25.ResultsA total of 740 students were included in the final analysis. Of them, 274 (37.0%) were male students and 466 (63.0%) were female students. The mean age of the study participants is 19.9 ± 1.6 years. The findings showed that 61.9% of the study participants were at intermediate and high risk of diabetes (59.7 and 2.2%, respectively). The majority 85.7% of male students were at intermediate risk of diabetes, and 5.8% were at high risk of diabetes. In total, 44.4% of female students were at intermediate risk of diabetes, and none of them were at high risk of diabetes. For the following variables (age, gender, college name, area of the university, academic years, weight, height, and BMI), the differences were statistically significant between different categories of diabetes risk scores (P-values &lt; 0.005).ConclusionMore than half of the students at the Hail University of Saudi Arabia have an intermediate and high risk of T2DM. Male students are at a higher risk compared to female students. The high risk of T2DM among university students should be seriously considered.