bluuebunny/crossref_metadata_2025_split huggingface dataset:
Progress and outlook of Sn–Pb mixed perovskite solar cells
Authors: Lee Hyemin , Kang Seok Beom , Lee Sangwook , Zhu Kai , Kim Dong Hoe 
Published: June 2023

AbstractOrganic–inorganic hybrid perovskites have revolutionized solar cell research owing to their excellent material properties. Most previous research has been done on Pb-based perovskites. Recently, efforts to discover a Pb-free or Pb-less perovskite material with an ideal bandgap ranging 1.1–1.3 eV have led researchers to investigate Sn–Pb mixed perovskites. Sn–Pb mixed perovskites have a bandgap of ~ 1.25 eV, which is suitable for high-efficiency single-junction and perovskite/perovskite tandem solar cells. Moreover, the Pb content of Sn–Pb mixed perovskites is 50–60% lower than that of Pb-based perovskites, partially mitigating the Pb toxicity issue. However, incorporating Sn2+into the crystal structure also causes various drawbacks, such as inhomogeneous thin film morphologies, easy oxidation of Sn2+, and more vulnerable surface properties. Researchers have made substantial progress in addressing these challenges through improvements in compositional design, structural optimization, precursor design, and surface treatments. In this review, we provide a comprehensive overview of the progress in Sn–Pb mixed perovskite solar cells. Furthermore, we analyze the key variables and trends as well as provide an outlook for future directions in the research on Sn–Pb mixed perovskites.Graphical Abstract
Distinct taxonomic and functional profiles of high Arctic and alpine permafrost-affected soil microbiomes
Authors: Sannino Ciro , Qi Weihong , Rüthi Joel , Stierli Beat , Frey Beat 
Published: June 2023

Abstract
Background
Global warming is affecting all cold environments, including the European Alps and Arctic regions. Here, permafrost may be considered a unique ecosystem harboring a distinct microbiome. The frequent freeze–thaw cycles occurring in permafrost-affected soils, and mainly in the seasonally active top layers, modify microbial communities and consequently ecosystem processes. Although taxonomic responses of the microbiomes in permafrost-affected soils have been widely documented, studies about how the microbial genetic potential, especially pathways involved in C and N cycling, changes between active-layer soils and permafrost soils are rare. Here, we used shotgun metagenomics to analyze the microbial and functional diversity and the metabolic potential of permafrost-affected soil collected from an alpine site (Val Lavirun, Engadin area, Switzerland) and a High Arctic site (Station Nord, Villum Research Station, Greenland). The main goal was to discover the key genes abundant in the active-layer and permafrost soils, with the purpose to highlight the potential role of the functional genes found.

Results
We observed differences between the alpine and High Arctic sites in alpha- and beta-diversity, and in EggNOG, CAZy, and NCyc datasets. In the High Arctic site, the metagenome in permafrost soil had an overrepresentation (relative to that in active-layer soil) of genes involved in lipid transport by fatty acid desaturate and ABC transporters, i.e. genes that are useful in preventing microorganisms from freezing by increasing membrane fluidity, and genes involved in cell defense mechanisms. The majority of CAZy and NCyc genes were overrepresented in permafrost soils relative to active-layer soils in both localities, with genes involved in the degradation of carbon substrates and in the degradation of N compounds indicating high microbial activity in permafrost in response to climate warming.

Conclusions
Our study on the functional characteristics of permafrost microbiomes underlines the remarkably high functional gene diversity of the High Arctic and temperate mountain permafrost, including a broad range of C- and N-cycling genes, and multiple survival and energetic metabolisms. Their metabolic versatility in using organic materials from ancient soils undergoing microbial degradation determine organic matter decomposition and greenhouse gas emissions upon permafrost thawing. Attention to their functional genes is therefore essential to predict potential soil-climate feedbacks to the future warmer climate.
A loop-mediated isothermal amplification assay for the rapid diagnosis of soybean rust caused by Phakopsora pachyrhizi
Authors: Ouyang Haibing , Zhang Zhichao , Sun Guangzheng , Yang Huawei , Ye Wenwu , Wang Yuanchao 
Published: June 2023

AbstractSoybean rust caused by the fungus Phakopsora pachyrhizi is one of the most destructive diseases to soybean production worldwide. For the rapid diagnosis and the control of soybean rust, we developed a loop-mediated isothermal amplification (LAMP) assay that targets a P. pachyrhizi-specific gene (Phapa_6409908) identified from a comparative genomic analysis of 61 Pucciniomycotina strains. Using a set of screened primers and the optimized reaction conditions of 62°C for 70 min, the LAMP assay can detect P. pachyrhizi while excluding other plant pathogens. The assay consistently showed high sensitivity in detecting low contents of P. pachyrhizi DNA (10 pg). We confirmed the practical application of this LAMP assay in diagnosing soybean rust using soybean leaf samples collected from fields in four cities of Sichuan Province, China, in 2020 and 2021. The developed LAMP assay provides a specific, sensitive, and rapid method for the diagnosis of soybean rust caused by P. pachyrhizi, which can assist in the prediction, prevention, and control of this major soybean disease.
Image encryption based on 2DNA encoding and chaotic 2D logistic map
Authors: Alrubaie Asmaa Hasan , Khodher Maisa’a Abid Ali , Abdulameer Ahmed Talib 
Published: June 2023

AbstractDNA has recently been investigated as a possible medium concerning ultra-compact information storage and ultra-scale computation. The development of secure image encryption systems has recently received a certain effective and new direction from chaos-based cryptographic algorithms. This paper proposes a novel image encryption algorithm, 2DNALM, based on double-dynamic DNA sequence encryption and a chaotic 2D logistic map. The three phases regarding the suggested approach are as follows: the first phase involves permuting the positions of the pixels using a position key-based scrambling operation. The second phase involves double DNA encoding on scrambled images using various rules by DNA cryptography concept to produce an encoded image, and in the final step, an image which has been encoded is encrypted using XOR operation and chaotic keys created through a chaotic 2D logistic map. The entropy analysis and experimental findings show that the suggested scheme exhibits great encryption and withstands several common attacks.
Intracranial Efficacy of Adagrasib in Patients From the KRYSTAL-1 Trial With KRASG12C-Mutated Non–Small-Cell Lung Cancer Who Have Untreated CNS Metastases
Authors: Negrao Marcelo V. , Spira Alexander I. , Heist Rebecca S. , Jänne Pasi A. , Pacheco Jose M. , Weiss Jared , Gadgeel Shirish M. , Velastegui Karen , Yang Wenjing , Der-Torossian Hirak , Christensen James G. , Sabari Joshua K. 
Published: June 2023

Clinical trials frequently include multiple end points that mature at different times. The initial report, typically based on the primary end point, may be published when key planned co-primary or secondary analyses are not yet available. Clinical Trial Updates provide an opportunity to disseminate additional results from studies, published in JCO or elsewhere, for which the primary end point has already been reported. Patients with Kirsten rat sarcoma viral oncogene homolog ( KRAS)–mutated non–small-cell lung cancer (NSCLC) and untreated CNS metastases have a worse prognosis than similar patients without KRAS mutations. Adagrasib has previously demonstrated CNS penetration preclinically and cerebral spinal fluid penetration clinically. We evaluated adagrasib in patients with KRASG12C-mutated NSCLC and untreated CNS metastases from the KRYSTAL-1 trial (ClinicalTrials.gov identifier: NCT03785249 ; phase Ib cohort), in which adagrasib 600 mg was administered orally, twice daily. Study outcomes included the safety and clinical activity (intracranial [IC] and systemic) by blinded independent central review. Twenty-five patients with KRASG12C-mutated NSCLC and untreated CNS metastases were enrolled and evaluated (median follow-up, 13.7 months); 19 patients were radiographically evaluable for IC activity. Safety was consistent with previous reports of adagrasib, with grade 3 treatment-related adverse events (TRAEs) in 10 patients (40%) and one grade 4 (4%) and no grade 5 TRAEs. The most common CNS-specific TRAEs included dysgeusia (24%) and dizziness (20%). Adagrasib demonstrated an IC objective response rate of 42%, disease control rate of 90%, progression-free survival of 5.4 months, and median overall survival of 11.4 months. Adagrasib is the first KRASG12C inhibitor to prospectively demonstrate IC activity in patients with KRASG12C-mutated NSCLC and untreated CNS metastases, supporting further investigation in this population.
Patterns of Relapse in Australian Patients With Clinical Stage 1 Testicular Cancer: Utility of the Australian and New Zealand Urogenital and Prostate Cancer Trials Group Surveillance Recommendations
Authors: Conduit Ciara , Lewin Jeremy , Weickhardt Andrew , Lynam James , Wong Shirley , Grimison Peter , Sengupta Shomik , Pranavan Ganes , Parnis Francis , Bastick Patricia , Campbell David , Hansen Aaron R. , Leonard Matt , McJannett Margaret , Stockler Martin R. , Gibbs Peter , Toner Guy , Davis Ian D. , Tran Ben , Kuchel Anna 
Published: June 2023

PURPOSE International guidelines advocate for active surveillance as the preferred treatment strategy for patients with stage 1 testicular cancer after orchidectomy although a personalized discussion is required. MATERIALS AND METHODS We conducted an analysis of individuals registered in iTestis, Australia's testicular cancer registry, to describe the patterns of relapse and outcomes of patients treated in Australia where the Australian and New Zealand Urogenital and Prostate Cancer Trials Group Surveillance Recommendations are widely adopted. RESULTS A total of 650 individuals diagnosed between 2000 and 2020 were included, 63% (411 of 650) seminoma and 37% (239 of 650) nonseminoma. The median age was 34 years (range 14-74). 26% (106 of 411) with seminoma and 15% (36 of 239) nonseminoma received adjuvant chemotherapy. After a median follow-up of 43 months (range 0-267) postorchidectomy, relapse occurred in 10% (43 of 411) of seminoma and 18% (43 of 239) of nonseminoma. The two-year relapse-free survival was 92% (95% CI, 89 to 95) and 82% (95% CI, 78 to 87) in seminoma and nonseminoma, respectively. All relapses (86 of 86) were detected at a routine surveillance visit; 98% (85 of 86) were asymptomatic and detected solely through imaging (62 of 86, 72%), tumor markers (6 of 86, 7%), or a combination (17 of 86, 20%). The most common relapse site was isolated retroperitoneal lymphadenopathy (53 of 86, 62%). No nonpulmonary visceral metastases occurred. At relapse, 98% (84 of 86) had International Germ Cell Cancer Collaborative Group (IGCCCG) good prognosis; 2 of 86 intermediate prognosis (both nonseminoma). No deaths occurred. CONCLUSION In our cohort of stage 1 testicular cancer, where national surveillance recommendations have been widely adopted, recurrences were detected at routine surveillance visits and, almost exclusively, asymptomatic with IGCCCG good-prognosis disease. This provides reassurance that active surveillance is safe.
Neurological Examination Frequency and Time-to-Delirium After Traumatic Brain Injury
Authors: Chotai Silky , Chen Jeffrey W. , Turer Robert , Smith Candice , Kelly Patrick D. , Bhamidipati Akshay , Davis Philip , McCarthy Jack T. , Bendfeldt Gabriel A. , Peyton Mary B. , Dennis Bradley M. , Terry Douglas P. , Guillamondegui Oscar , Yengo-Kahn Aaron M. 
Published: June 2023

BACKGROUND:
Frequent neurological examinations in patients with traumatic brain injury (TBI) disrupt sleep-wake cycles and potentially contribute to the development of delirium.

OBJECTIVE:
To evaluate the risk of delirium among patients with TBI with respect to their neuro-check frequencies.

METHODS:
A retrospective study of patients presenting with TBI at a single level I trauma center between January 2018 and December 2019. The primary exposure was the frequency of neurological examinations (neuro-checks) assigned at the time of admission. Patients admitted with hourly (Q1) neuro-check frequencies were compared with those who received examinations every 2 (Q2) or 4 (Q4) hours. The primary outcomes were delirium and time-to-delirium. The onset of delirium was defined as the first documented positive Confusion Assessment Method for the Intensive Care Unit score.

RESULTS:
Of 1552 patients with TBI, 458 (29.5%) patients experienced delirium during their hospital stay. The median time-to-delirium was 1.8 days (IQR: 1.1, 2.9). Kaplan-Meier analysis demonstrated that patients assigned Q1 neuro-checks had the greatest rate of delirium compared with the patients with Q2 and Q4 neuro-checks (P < .001). Multivariable Cox regression modeling demonstrated that Q2 neuro-checks (hazard ratio: 0.439, 95% CI: 0.33-0.58) and Q4 neuro-checks (hazard ratio: 0.48, 95% CI: 0.34-0.68) were protective against the development of delirium compared with Q1. Other risk factors for developing delirium included pre-existing dementia, tobacco use, lower Glasgow Coma Scale score, higher injury severity score, and certain hemorrhage patterns.

CONCLUSION:
Patients with more frequent neuro-checks had a higher risk of developing delirium compared with those with less frequent neuro-checks.
Development and evaluation of prevention bundle for neonatal healthcare-associated infections: an interventional study
Authors: Rani Usha , Lewis Leslie E , Chawla Kiran , Naha Anup , Kumar Praveen 
Published: June 2023

Background: Neonatal healthcare-associated infection (HAI) globally is the leading preventable cause of neonatal mortality. Neonatal mortality in India is also very high. Considering that HAIs can be prevented globally, there are disparities in resources; the current study aimed at developing locally feasible and effective prevention bundles for neonatal HAIs. Methods: A mixed-method study was conducted at one tertiary care teaching hospital's level IV Neonatal Intensive Care Unit. The study explores the causes of neonatal HAIs, current processes, benchmark practices, gaps in current practices with HAIs, root-cause analysis and system process mapping, and failure mode effect analysis. Observations, interviews, brainstorming activities, and a survey were conducted. Written and audio-video recorded prevention bundle was developed and implemented using a quasi-experimental study design. Results: Process standardisation, healthcare worker training, hand hygiene practices, nursing care process and vascular access process were identified as key improvement areas to prevent neonatal HAIs. Out of eighteen identified processes, three processes were standardised. All the healthcare providers were trained at three-time intervals of three months each. After implementing the prevention bundle, there was a significant decline in the rate of HAIs, reducing it from 9.6 to 7.0 per 100 admissions >48 hours. The bacteraemia rate fell from 5.2 per 1000 patient days to 2.6 per 1000 patient days and was statistically significant on a two-tailed student t-test with 95% CI with p-value=0.00073. Conclusions: Our developed prevention bundle for neonatal HAIs was significantly effective and reproducible for healthcare workers' training and development. Considering variations in global infection control practices and resources constraint, it is effective to develop a local prevention bundle for neonatal HAIs.
Dietary and obstetric correlates of anaemia among pregnant women: a cross-sectional study from the Wa municipality, Ghana
Authors: Faabie Alfred Pie , Buunaaim Alexis DB , Suara Sufyan Bakuri , Mornah Louis Nebayeng , Koray Munawar Harun , Zunuo Anzunna Doreen 
Published: June 2023

Introduction/Aims Anaemia is the most severe pregnancy-related hematological condition globally and affects approximately 32.4 million pregnant women. This study's aim was to identify factors influencing anaemia in pregnancy at 36 weeks in the Wa municipality. Methods A descriptive cross-sectional study was conducted among 410 pregnant women. The participants' haemoglobin levels and obstetric variables were extracted from antenatal record books. Data were analysed using multivariate binary logistics regression analysis to determine risk factors associated with anaemia in pregnancy at 36 weeks. Results The prevalence of anaemia at 36 weeks was 81.5%. Predictors included no previous use of family planning methods, paragravidity, low dietary diversity and an average monthly income of <1000 Ghanaian Cedi. Conclusions The prevalence of anaemia at 36 weeks was high. Preventive interventions targeting preconception nutrition and promoting regular antenatal care visits throughout pregnancy are urgently required.
Prolonged second stage labour and maternal-neonatal outcomes in northern Ethiopia: a retrospective cohort study
Authors: Kumsa Henok , Mullu Getachew , Dimtsu Balem , Gebre Gelawdiwos , Reda Mihreat-ab , Yimer Nigus 
Published: June 2023

Background/Aims Prolonged second stage labour is thought to be a risk factor for obstetric and perinatal complications. However, its effect on complications has been found to be inconclusive by a broad range of studies. This study aimed to investigate the relationship between adverse maternal and neonatal outcomes and prolonged second stage of labour in northern Ethiopia. Methods This retrospective cohort study included 1055 systematically selected records of women who gave birth between 1 September 2014 and 30 August 2017. Binary and multivariable logistic regression models were used to test the effect of prolonged second stage labour on maternal and neonatal outcomes. Results Adverse outcomes significantly associated with prolonged second stage labour were: operative vaginal birth (P<0.010), caesarean birth (P<0.010), puerperal sepsis (P=0.010) and third- or fourth-degree perineal tears (P=0.028), episiotomy (P=0.003), a 5-minute Apgar score <7 (P=0.030) and meconium-stained amniotic fluid (P<0.010). Conclusions Multiple adverse outcomes were significantly associated with prolonged second stage labour. Therefore, close monitoring, follow up and timely interventions are needed for women experiencing prolonged second stage labour.
Real-time computing for a holographic 3D display based on the sparse distribution of a 3D object and requisite Fourier spectrum
Authors: Sando Yusuke , Goto Yutaro , Barada Daisuke , Yatagai Toyohiko 
Published: June 2023

In holographic three-dimensional (3D) displays, the surface structures of 3D objects are reconstructed without their internal parts. In diffraction calculations using 3D fast Fourier transform (FFT), this sparse distribution of 3D objects can reduce the calculation time as the Fourier transform can be analytically solved in the depth direction and the 3D FFT can be resolved into multiple two-dimensional (2D) FFTs. Moreover, the Fourier spectrum required for hologram generation is not the entire 3D spectrum but a partial 2D spectrum located on the hemispherical surface. This sparsity of the required Fourier spectrum also reduces the number of 2D FFTs and improves the acceleration. In this study, a fast calculation algorithm based on two sparsities is derived theoretically and explained in detail. Our proposed algorithm demonstrated a 24-times acceleration improvement compared with a conventional algorithm and realized real-time hologram computing at a rate of 170 Hz.
How do disease control measures impact spatial predictions of schistosomiasis and hookworm? The example of predicting school-based prevalence before and after preventive chemotherapy in Ghana
Authors: Kulinkina Alexandra V. , Farnham Andrea , Biritwum Nana-Kwadwo , Utzinger Jürg , Walz Yvonne 
Published: June 2023

Background
Schistosomiasis and soil-transmitted helminth infections are among the neglected tropical diseases (NTDs) affecting primarily marginalized communities in low- and middle-income countries. Surveillance data for NTDs are typically sparse, and hence, geospatial predictive modeling based on remotely sensed (RS) environmental data is widely used to characterize disease transmission and treatment needs. However, as large-scale preventive chemotherapy has become a widespread practice, resulting in reduced prevalence and intensity of infection, the validity and relevance of these models should be re-assessed.

Methodology
We employed two nationally representative school-based prevalence surveys of Schistosoma haematobium and hookworm infections from Ghana conducted before (2008) and after (2015) the introduction of large-scale preventive chemotherapy. We derived environmental variables from fine-resolution RS data (Landsat 8) and examined a variable distance radius (1–5 km) for aggregating these variables around point-prevalence locations in a non-parametric random forest modeling approach. We used partial dependence and individual conditional expectation plots to improve interpretability of results.

Principal findings
The average school-level S. haematobium prevalence decreased from 23.8% to 3.6% and that of hookworm from 8.6% to 3.1% between 2008 and 2015. However, hotspots of high-prevalence locations persisted for both infections. The models with environmental data extracted from a buffer radius of 2–3 km around the school location where prevalence was measured had the best performance. Model performance (according to the R2 value) was already low and declined further from approximately 0.4 in 2008 to 0.1 in 2015 for S. haematobium and from approximately 0.3 to 0.2 for hookworm. According to the 2008 models, land surface temperature (LST), modified normalized difference water index, elevation, slope, and streams variables were associated with S. haematobium prevalence. LST, slope, and improved water coverage were associated with hookworm prevalence. Associations with the environment in 2015 could not be evaluated due to low model performance.

Conclusions/significance
Our study showed that in the era of preventive chemotherapy, associations between S. haematobium and hookworm infections and the environment weakened, and thus predictive power of environmental models declined. In light of these observations, it is timely to develop new cost-effective passive surveillance methods for NTDs as an alternative to costly surveys, and to focus on persisting hotspots of infection with additional interventions to reduce reinfection. We further question the broad application of RS-based modeling for environmental diseases for which large-scale pharmaceutical interventions are in place.
Quality, Shelf Life, and Demand Uncertainty
Authors: Zhang Anzhou 
Published: June 2023

Abstract
This paper studies a monopolist’s choices of quality and shelf life of a perishable good in the presence of demand uncertainty and sunk production cost. It shows that, in response to demand uncertainty, the firm typically produces multiple products which differ in quality and shelf life; under certain conditions, products with a longer shelf life are of lower quality; a probability distribution of demand which first-order (second-order) stochastically dominates another induces more (more or fewer) product varieties. It also provides conditions under which a higher quality product has a higher absolute profit margin but a lower percentage margin.