bluuebunny/crossref_metadata_2025_split huggingface dataset:
New approach to estimate effectiveness of vaccination against COVID - 19: a proportional case vaccinated-based model
Authors: Joghatayi Marzieh , Mirahmadizadeh Alireza , Hassanzadeh Jafar 
Published: July 2023

Abstract
Background
Over the past decades, Outbreaks of numerous infectious diseases have become international emergencies; one of the epidemics of the 21st century was the Covid-19 pandemic. Since the beginning of the corona virus, mass vaccination has been proposed as one of the most effective ways to end this epidemic. Yet, even after vaccination, re-infection with severe acute respiratory syndrome coronavirus2 (SARS-CoV-2) may occur which is called breakthrough infections, because the Covid-19 vaccines do not offer 100% protection. For this reason, our goal is to investigate the effectiveness of the covid-19 vaccination in reducing cases of infection and mortality
Methods
In this study, Proportional Vaccinated Case (P.V.C) was used to calculate the effectiveness of vaccination in the city of Shiraz and the cities covered by Shiraz University of Medical Sciences between August 23 and December 21, 2022. Our data is gathered from electronic collection systems, including the Sib system, the CORONA LAB system, and the MCMC system.
Result
the Effectiveness of all vaccines were studied in reducing morbidity and mortality in people who had injected their second dose of vaccine and 14 days or more had passed since their injection was 48.17% and 97.47%, respectively. In contrast, for BIBP-CorV vaccine these numbers are estimated to be 49.58% and 92.88% respectively.
Conclusion
Finally, the aim of this study was to use a new approach to calculate the effectiveness of the vaccine in reducing mortality and infection. Our study showed that vaccination has been effective in reducing deaths caused by covid-19، although the effective results of vaccination in our study in reducing cases of infection wasn't very high .Yet, more and more extensive studies on different strains of the Covid-19 virus are required to prove this issue.
Design Structure Matrix (DSM) Approach to Design a Surgery Robot
Authors: Zamani Forough , Beigzadeh Borhan 
Published: July 2023

Abstract
The product development process (PD) can be viewed as an optimization problem to minimize design loops. Nowadays, the complexity of the system components has increased due to technological progress. These complex interconnections between the different components of the system can complicate and prolong the design process. In such cases, the decision on the sequence of design steps can depend heavily on the experience of the designer. But, other methods can systematize the design process, and help designers and engineers to design more reliably and faster. In this study, we used the Design Structure Matrix (DSM) approach to design and develop a surgical robot mainly used in spine surgery. The main 50 parameters of the robot such as the number of degrees of freedom, motor torque, length of the links, and their relationships described by the kinematics and dynamics of the robot, were inserted into the matrix. These parameters are the minimum parameters required for the initial design of the mechanical structure of a robot. DSM determined the main design loops of our desired system. The most challenging loop of the robot was the one related to choosing motors whose parameters were tightly connected to other robot's parameters. After rearranging the order of parameters and simplifying, and decreasing the loops, a more rational and doable design road map was obtained. The result of the final model showed that it fully met the criteria and constraints of the simulation test for spine surgery.
Tensorial Multi-view Subspace Clustering with Side Constraints for Elevator Security Warning
Authors: Xu Huangzhen , Ruan Licheng , Ni Yuzhou , Yin Hongwei , Yu Pu , Chen Xinmin 
Published: July 2023

Abstract
In recent years, using clustering technology to realize equipment security warning is a research hotspot in the field of data mining applications. However, due to the lack of data fusion mechanism and prior knowledge guidance, the performance of most existing methods is limited when applied to complex equipment such as elevator. In this paper, a novel Tensorial Multi-view Subspace Clustering with Side constraints (TMSCS) is proposed for elevator security warning, which first introduces tensorial multi-view subspace learning to achieve data fusion based on high-order correlation. Secondly, the prior knowledge is formalized as side constraints between samples through adaptive graph learning, where certain elevators is forced to have similar or dissimilar operation status. Thirdly, a unified model combining tensorial multi-view subspace learning and adaptive graph learning is constructed to eliminate the instability caused by phased learning. Furthermore, an efficient optimization algorithm is designed to solve this model. Extensive experiments on several benchmark datasets demonstrate the superiority of our method, and the experimental results on real elevator status datasets demonstrate that our method accurately identifies the operating status of each elevator equipment.
Dysregulation of the miRNA-30a-5p/B4GALT5 axis leads to cell proliferation and is associated with M1 Macrophage Polarization in PNH
Authors: zeng lijie , Wang Chaomeng , Li Liyan , Liu Zhaoyun , Wang Honglei , Chen Yingying , Wu Junshu , Wang Guanrou , Li Lijuan , Liu Hui , Fu Rong 
Published: July 2023

Abstract
Background：MicroRNAs (miRNAs) play diverse roles in various biological processes. However, their role in Paroxysmal Nocturnal Hemoglobinuria (PNH) is not well understood. To investigate the involvement of miRNAs in PNH, we conducted a re-analysis of the GEO database and identified miRNA-30a-5p as the most promising candidate for further mechanism research.
Methods: We have constructed a PIGA knock-out K562 cell line and PIGAconditional knock-out mice model by CRISPR/cas9 technology. Furthermore, FACS and colony formation assays were used to clarify proliferative and apoptosis abilities of PNH cells. FACS was used to clarify M1 Macrophage Polarization in mouse bone marrow-derived macrophages (BMDMs). Luciferase assay was used to indicate miRNA target gene. RT-PCR and western blot were used to verify the relationship between miR-30a-5p, B4GALT5 and PI3K/AKT signaling.
Results: Our study revealed a significant upregulation of miR-30a-5p in Flaer negative cells compared to Flaer positive cells, in a cohort of 10 PNH patients. Cell colony formation and cell cycle analysis demonstrated that the miRNA-30a-5p mimics group exhibited a higher capacity for proliferation, while the miRNA-30a-5p inhibitor group showed opposite effects. Subsequent luciferase assay results confirmed that miRNA-30a-5p targeted the B4GALT5 gene, which was found to be significantly downregulated in Flaer negative cells from 15 PNH patients. In vitro assays showed that the miRNA-30a-5p/B4GALT5 axis significantly promoted cell proliferation by activating PI3K/AKT signaling. Additionally, our study is the first to describe the polarization state of macrophages in the bone marrow microenvironment of PNH patients, where we observed a higher mean fluorescence intensity (MFI) of CD80 and CD86, markers of M1 macrophages, on macrophages from PNH patients compared to normal controls. Furthermore, siB4GALT5 increased the markers of M1 macrophages in BMDMs, and miRNA-30a-5p inhibitor induced M2-like macrophage polarization, which was markedly reversed in the miRNA-30a-5p inhibition+siB4GALT5 group.
Conclusion: Our study has identified that the miRNA-30a-5p targets the B4GALT5 gene, and miRNA-30a-5p/B4GALT5 axis facilitates the proliferation of PNH clones via the PI3K/AKT signaling pathway. Additionally, our findings provide initial evidence that the miRNA-30a-5p/B4GALT5 axis may play a potential role in M1 macrophage polarization in the bone marrow of PNH patients.
Operational Efficiency Improvements in the Portuguese Electricity Sector
Authors: Hou Zheng , Roseta-Palma Catarina , Ramalho Joaquim 
Published: July 2023

Abstract
Efficiency has long been an issue of concern in the electricity sector. Most existing studies relate technical efficiency in electricity generation to policy factors while that in transmission and distribution is associated with environmental factors. Although firm operation is also a relevant perspective on this topic, its explicit impact upon technical efficiency has rarely been studied. In order to analyze the evolution and operational determinants of productive and cost efficiency in the Portuguese electricity sector (including generation from different sources, trade, transmission and distribution), this study estimates Stochastic Frontier models using firm-level panel data from 2006 to 2019, covering the period of liberalization of the Portuguese electricity market. The evidence is consistent with the expectation on efficiency gains from the market reform. However, such improvement is likely to slow down and needs to be consolidated. Results on the inefficiency determinants suggest that it is possible to improve productive technical efficiency by encouraging investment in fixed assets, higher average hourly wage and moderate average working hours.
JEL classification: D24, L23, O25, Q40
A Case Study on Working Condition of Brick Kiln Workers of Rohilkhand region, U.P, India
Authors: Ali Shaheen Efrah 
Published: July 2023

Abstract
The Socioeconomic condition of workers is adversely affected due to the poor working condition and Worker’s Harassment by Contractor. In recent years, there has been a shortage of workforce as the younger generation no longer wants to be linked with the brick kiln sector. They are not getting proper workplace environment and Workplace Harassment takes place due to labour bondage condition of labour between Brick kiln owner & Contractor. Thus, it’s important to analyze the working Condition of brick kiln industry workers. The study brings out the reality of the workers of brick kiln, their vulnerability, migration issues, social insecurity, potential health risks, & the hazardous atmosphere that they thrive in their day-to-day lives. Primary data was collected with help of face to face interview schedule from the different 6 brick kiln of Rohilkhand region, U.P. India.(n = 320). For Analysis of data, Descriptive statistics (frequency and percentage) and Chi-Square test were used. The study revealed that the majority of the workers are male respondents at the brick kiln with low education level & facing major health issues. The majority of the workers claimed that they didn’t get proper sanitation (84.3%) and drinking water (68.7%) and facing Wages Harassment by Contractor at workplace (71.8%).
Calcium Carbonate (Tums)-Associated Milk-Alkali Syndrome as a Cause of Altered Mental Status in the Emergency Department: A Case Report
Authors: Leff Rebecca , Madsen  
Published: July 2023

Abstract
Background:
Milk-alkali syndrome (MAS) resulting in hypercalcemic crisis represents a life-threatening medical emergency in the setting of excessive calcium and absorbable alkali ingestion. While an uncommon cause of altered mental status and acute renal failure in the emergency department, emergency medicine clinicians should be aware of this syndrome due to significant morbidity and mortality if left undiagnosed.
Case presentation:
A 63-year-old woman with history of familial hypoparathyroidism presented to our emergency department with worsening confusion, slurred speech, generalized weakness, and failure to thrive over the course of one month. Review of systems was positive for tachypnea, polydipsia, diffuse musculoskeletal pain, dehydration, poor oral intake, nausea with nonbilious nonbloody emesis, and severe fatigue. Family reported increasing difficulties with completing activities of daily living including ambulation and medication compliance. Physical examination yielded no focal neurologic deficits concerning for ischemic stroke. Laboratory investigations revealed acute renal injury, metabolic alkalosis, and severe hypercalcemia. CT imaging of the head revealed no acute intracranial abnormalities. During evaluation, the patient revealed that she had been taking 15 calcium carbonate (tums) tablets daily, along with vitamin-D and calcitriol, as a result of increased symptoms of gastroesophageal reflux disease. The patient received aggressive fluid and subcutaneous calcitonin in the emergency department. She was admitted to the hospital, where she continued to receive aggressive intravenous fluids. Calcium supplementation was withheld and chlorthalidone discontinued. After a thorough negative workup, the etiology of her hypercalcemia was deemed most likely secondary to milk-alkali syndrome. She was discharged home in stable condition on hospital day 6 without receiving hemodialysis.
Conclusions:
Emergency physicians should be vigilant of MAS given the potential for high morbidity if left undiagnosed. Emergency clinicians should ask about calcium supplements, as these often won't be listed on the patient's medication list and can be purchased over the counter.
Designing of Anticancer Therapeutical Strategies: Implications of Molecular Docking Studies of Phytochemicals of Cichorium Intybus to Metabolic Regulatory Enzymes
Authors: Pathak Abhishek , Singh S. P. , Prakash Atul , Tiwari Apoorv 
Published: July 2023

Background:
Altered metabolism is a significant characteristic of cancer, with malignant cells exhibiting elevated levels of enzymes involved in bioenergetic and biosynthetic processes. Targeting metabolic enzymes has become a key approach in anticancer therapy, leading to the discovery of metabolic inhibitors such as 3-bromopyruvate (3-BP) with broad anticancer activity. Novel therapeutics are needed to treat and prevent this fatal disease, and natural substances are gaining attention as potentially safer alternatives to conventional therapies like chemotherapy.

Methods:
This study aimed to identify novel drug-like molecules for anticancer treatment using an in-silico approach. Twenty-eight phytocompounds from Cichorium intybus were selected for molecular docking against target enzymes involved in the TCA and glycolysis cycles and compared with 3-BP, a standard broad-spectrum anticancer drug, using Maestro (Schrodinger software).

Results:
Comparison of docking scores revealed that the phytoconstituents of Cichorium intybus exhibited stronger binding to metabolic enzymes compared to 3-BP. Additionally, drug-likeness analysis using the admetSAR and Lipinski filter indicated that most of the selected phytoconstituents and 3-BP demonstrated desirable criteria as anticancer drugs.

Conclusion:
Conclusion
This research offers insightful information about molecular interactions between phytoconstituents of Cichorium intybus, 3-BP, and metabolic enzymes. These findings may contribute to the development and optimization of therapeutic approaches against cancer, utilizing these phytoconstituents as ligands.
A Review of Modern and Traditional Approaches for the Management of Pulmonary Hypertension
Authors: Verma Anuradha , Garg Anshika , Ahmad Sultan , Haider Saquib , Kumar Babita , Chauhan Ritu , Singh Manish K. , Mondal Sambhu Charan 
Published: July 2023

Research Problem:
Hypertension, either high blood pressure or pulmonary hypertension,
both affect the life of patients in many ways.

Research Questions:
Does Pulmonary hypertension similar to high blood pressure?

:
Does it affect old age people or the neonatal age groups also?

:
What were the reasons for pulmonary hypertension?

:
Does pulmonary hypertension manageable with modern and traditional drugs?

Literature Review:
The purpose of the literature review is to identify the targeted therapy for pulmonary
hypertension and also include the plants that may be effective for the management of pulmonary
hypertension.

Conclusion:
The author has reviewed many targeted drugs that are presently used, and many are in
research that was found effective in making the life of patients as normal as possible.

:
They also reviewed about 15 herbal plants which were found effective in the management of the
disease.

:
As pulmonary hypertension is not treatable, it can only be managed by changing lifestyle and food
habits; therefore, the authors emphasized reviewing the traditional approach for the management of
pulmonary hypertension.
Pengembangan Alat Latihan Standing Punching Pad Pada Tinju
Authors: Iqroni David 
Published: July 2023

Penelitian ini bertujuan untuk meghasilkan suatu produk berupa alat latihan yang dapat digunakan untuk berlatih dan melatih kecepatan pukulan serta reaksi untuk atlet beladiri tinju. Metode penelitian yang digunakan adalah Research and Development. Langkah-langkah penelitian ini menadaptasi dari langkah penelitian Sugiyono yang terdiri dari 13 langkah namun peneliti hanya mengadaptasi 10 langkah sesuai degan tujuan penelitian pengembangan ini. Uji coba kelompok kecil dilakukan di gedung tinju sasana kota baru jambi terhadap 5 orang responden dan uji coba kelompok besar dilakukan di gedung tinju sasana kota baru jambi terhadap 10 orang atau seluruh isi populasi atlet tinju di gedung tinju sasana kota baru jambi. Penilaian kelayakan alat latihan standing punching pad dengan pengembangan yang dilakukan yakni menambahkan lengan untuk melatih kecepatan pukulan dan reaksi dilihat dari hasil validasi ahli materi sebesar 100% (layak) dan validasi ahli media sebesar 98,88 %(layak). Hasil uji coba kelompok kecil didapatkan penilaian 91,13 (layak), sedangkan kelompok besar didapatkan penilaian 91,39% (layak). Dengan demikian dapat disimpulkan bahwa alat dinyatakan layak dan dapat digunakan untuk berlatih dan melatih kecepatan pukulan serta reaksi.
Efektivitas Bidang Miring Pada Mata Pelajaran Senam Lantai Gerakan Rol Depan Siswa SDN 93 Kota Jambi Secara Blended Learning
Authors: Yulio Syahdan Siregar Aldo , Widowati Atri 
Published: July 2023

Tujuan penelitian ini adalah untuk membantu permasalahan dan memotivasi siswa kelas 3 SDN 93 Kota Jambi dalam melakukan gerakan Rol Depan. Penelitian ini menggunakan metode eksperimen semu, dalam penelitian ini terdapat satu kelompok eksperimen yang sengaja diberi perlakuan. Penelitian ini menggunakan One Group Pretest-Posttest Design yaitu satu kelompok yang diberi perlakuan, tetapi sebelum perlakuan diberikan terlebih dahulu tes awal (pretest), kemudian diakhiri perlakuan tes akhir (posttest). Berdasarkan hasil analisis data nilai L hitung untuk data tes awal dan tes akhir secara berurutan 0.0795 < Ltabel 0,1265; 0.0681 < Ltabel 0,1265. Maka berdasarkan analisis data ini dapat disimpulkan data tes awal dan tes akhir berdistribusi normal. Pada taraf signifikansi α = 0,05 maka diperoleh F tabel = 3,23. Maka Fhitung (1,77) < Ftabel (3,23) maka varian homogeny. Perbandingan harga antara t hitung dengan nilai presentil pada tabel distribusi – t, untuk taraf nyata α = 0,05 diperoleh t hitung (25,81) > t tabel (1,6772). Dari hasil penelitian ini terdapat efektivitas bidang miring pada mata pelajaran senam lantai gerakan rol depan siswa SDN 93 Kota Jambi secara blanded learning dengan t Hitung > t Tabel.
Pengaruh Latihan Wall Pass Terhadap Ketepatan Passing Tim Futsal Putri Tanjung Jabung Barat
Authors: Ratna Sari Pera , Nugraha Ugi 
Published: July 2023

Tujuan penelitian ini yaitu untuk mengetahui pengaruh latihan wall pass terhadap ketepatan passing tim futsal putri Tanjung Jabung Barat. Penelitian ini menggunakan metode eksperimen, dalam penelitian ini terdapat satu kelompok eksperimen yang sengaja diberikan perlakuan. Adapun rancangan penelitian ini menggunakan rancangan One Group Pretest-Postest Design. Maka pengambilan sampel pada penelitian ini menggunakan total sampeling yaitu sebesar 17 orang. Berdasarkan hasi analisis data diperoleh dengan jumlah sampel 17, mean 3,94, Standar Deviasi 1,64 dan thitung 9,92 untuk melihat apakah hipotesis Ho atau hipotesis Ha yang diterima sesuai dengan penjelasan diatas maka dibandingkan harga t hitung dengan harga t tabel. Perbandingan harga antar t hitung dengan nilai presentil pada tabel distribusi – t, untuk taraf nyata α = 0,05 dengan derajat kebebasan (dk) = (n – 1) = 16 diperoleh t hitung (9,92) > t tabel (1,7459). Ini berarti hipotesis Ha yang diterima dan Ho ditolak. Jadi dapat disimpulkan terdapat pengaruh latihan wall pass terhadap ketepatan passing tim futsal putri Tanjung Jabung Barat dengan t Hitung > t Tabel. Dapat di simpulkan bahwa terdapat pengaruh latihan wall pass terhadap ketepatan passing tim futsal putri Tanjung Jabung Barat.
Tingkat Motivasi Berprestasi Atlet Karate Kota Jambi dalam Menghadapi Porprov XXIII 2023
Authors: Suhartini Sugih , Rivaldo Excel Lee 
Published: July 2023

Tujuan penelitian ini adalah untuk mengetahui seberapa besarkah Tingkat Motivasi Berprestasi Atlet Karate FORKI Kota Jambi Dalam Menghadapi PORPROV XXIII 2023. Penelitian ini menggunakan penelitian metode deskriptif dengan menggunakan pendekatan kuantitatif yakni mendiskripsikan mengenai Tingkat Motivasi Berprestasi Atlet Karate FORKI Kota Jambi Dalam Menghadapi PORPROV XXIII 2023. Populasi dalam penelitian ini adalah Atlet Karate FORKI Kota Jambi yang terpilih untuk bertanding di PORPROV XXIII 2023 yang berjumlah 17 orang. Berdasarkan hasil yang di peroleh, hasil indikator intrinsik berada pada kategori sangat baik yaitu sebanyak 4 orang (24%). pada kategori baik sebanyak 1 orang (6%), pada kategori sedang sebanyak 3 orang (18%), pada kategori rendah sebanyak 4 orang (24%) dan terakhir pada kategori sangat rendah sebanyak 5 orang (29%). indikator ekstrinsik berada pada kategori sangat baik yaitu sebanyak 4 siswa (23%). pada kategori baik sebanyak 3 orang (18%), pada kategori sedang sebanyak 4 orang (24%), pada kategori rendah sebanyak 3 orang (18%) dan terakhir pada kategori sangat rendah sebanyak 3 orang (18%). Kesimpulan dalam penelitian ini adalah tingkat motivasi berprestasi atlet karate Forki Kota Jambi dalam menghadapi Porprov XXIII 2023 termasuk dalam kategori sangat tinggi, dengan besaran porsentase sebesar 85%.
RADIASI GELOMBANG ELEKTROMAGNETIK YANG DITIMBULKAN PERALATAN LISTRIK DI LINGKUNGAN UNIVERSITAS PGRI PALEMBANG
Authors: Jumingin Jumingin , Atina Atina , Iswan Joni , Haziza Nur , Ashari Balina 
Published: July 2023

Telah dilakukan penelitian radiasi gelombang elektromagnetik yang ditimbulkan peralatan listrik di Lingkungan Universitas PGRI Palembang khususnya Fakultas Sains dan Teknologi. Tujuan penelitian adalah untuk mengetahui seberapa besar medan listrik dan medan magnet yang dihasilkan peralatan listrik dan membandingkannya dengan nilai ambang batas radiasi gelombang elektromagnetik yang diperbolehkan di lingkungan kerja. Metode yang dipergunakan adalah pengukuran langsung di lapangan dilakukan secara direct reading. Pengukuran dilakukan selama 12 hari kerja, dengan jarak pengukuran 0cm dan 15cm dari alat elektronik. Hasil penelitian menunjukkan besarnya jangkauan kuat medan listrik dan medan magnet yang ditimbulkan peralatan elektronik adalah pada jarak 0cm 14 – 2000 V/m dan 0 – 677 µT dan pada jarak 15cm 101 – 721 V/m dan 0 – 17,03 µT. Kuat medan listrik yang ditmbulkan masih berada di bawah ambang batas kecuali oleh TV dan kuat medan magnet oleh Komputer, TV dan kipas angin berada di atas ambang batas yang diperbolehkan.