bluuebunny/crossref_metadata_2025_split huggingface dataset:
L’expérience à long terme des parents endeuillés en oncologie pédiatrique : une étude rétrospective de 2 à 18 ans après le décès d’un enfant
Authors: Bourque C.J. , Dumont E. , Martisella M. , Daoust L. , Cantin S. , Levasseur M.-C. , de Steur Q. , Duval M. , Marquis M.-A. , Sultan S. 
Published: February 2023

Objectifs : Cette étude rétrospective et transversale vise à comprendre l’expérience à long terme des parents endeuillés en oncologie pédiatrique et les différences du deuil parental en fonction du genre.
Matériel et méthodes : Un questionnaire multisectionnel coconstruit avec des cliniciens et intervenants en suivi de deuil a été tenu en ligne en 2018 et 2019. Les participants au sondage étaient des parents dont l’enfant était décédé au service d’hématologie-oncologie du CHU Sainte-Justine 2 à 18 ans auparavant. Des sections spécifiques sur les réactions, les changements et les souvenirs ont fait l’objet d’analyses descriptives.
Résultats : Les réponses de 48 parents ont été analysées. Les résultats indiquent que les mères ont tendance à modifier certaines de leurs activités sociales, alors que les pères cherchent plutôt à retrouver leurs habitudes. Les réactions initialement fortes des parents s’atténuent au fil du temps sans disparaître, en particulier la tristesse et les troubles du sommeil. Les parents ont des souvenirs apaisants des interactions et des soins reçus des intervenants en milieux clinique et communautaire même plusieurs années après le décès de leur enfant.
Conclusion : L’offre de soutien psychosocial communautaire et professionnel à long terme est pertinente, de même aux besoins des couples et aux besoins individuels des parents en fonction du genre.
Aspirin Use and Risk of Alzheimer’s Disease: A 2-Sample Mendelian Randomization Study
Authors: Ding Pingjian , Gorenflo Maria P. , Zhu Xiaofeng , Xu Rong 
Published: February 2023

Background: Observational studies have shown inconsistent findings of the relationships between aspirin use and the risk of Alzheimer’s disease (AD). Objective: Since residual confounding and reverse causality were challenging issues inherent in observational studies, we conducted a 2-sample Mendelian randomization analysis (MR) to investigate whether aspirin use was causally associated with the risk of AD. Methods: We conducted 2-sample MR analyses utilizing summary genetic association statistics to estimate the potential causal relationship between aspirin use and AD. Single-nucleotide variants associated with aspirin use in a genome-wide association study (GWAS) of UK Biobank were considered as genetic proxies for aspirin use. The GWAS summary-level data of AD were derived from a meta-analysis of GWAS data from the International Genomics of Alzheimer’s Project (IGAP) stage I. Results: Univariable MR analysis based on these two large GWAS data sources showed that genetically proxied aspirin use was associated with a decreased risk of AD (Odds Ratio (OR): 0.87; 95%CI: 0.77–0.99). In multivariate MR analyses, the causal estimates remained significant after adjusting for chronic pain, inflammation, heart failure (OR = 0.88, 95%CI = 0.78–0.98), or stroke (OR = 0.87, 95%CI = 0.77–0.99), but was attenuated when adjusting for coronary heart disease, blood pressure, and blood lipids. Conclusion: Findings from this MR analysis suggest a genetic protective effect of aspirin use on AD, possibly influenced by coronary heart disease, blood pressure, and lipid levels.
Evaluation of diet quality and associated factors in geriatric outpatients: A cross-sectional study
Authors: Baltacı Pelin , Tanrıöver Özlem , Yavuzer Hakan , Erdinçler Deniz Suna , Eyupoglu Ozan Emre 
Published: February 2023

BACKGROUND: In this study, our aim was to investigate the quality of dietary intake of elderly individuals and to identify the factors that may be associated with their diet quality. METHODS: This cross-sectional study was conducted with 198 elderly participants. Mini Nutritional Assessment (MNA) was used to evaluate nutritional status. The frequency of dietary intake was assessed using the Elderly Diet Index (EDI) score. RESULTS: The median age of study population was 76.0 years. The median EDI score was 27.0, moreover, only 27.3%of the study population had moderate or high diet quality. The results of the univariate analysis revealed that having an average or a poor appetite reduced the diet quality in the elderly which was statistically significantly ( p = 0.010 and p = 0.019, respectively), and each point increase in the MNA score statistically significantly increased the chance of moderate/good diet quality by 1.16 times. CONCLUSIONS: The poor diet quality of the elderly was associated with their education, appetite, nutritional, and smoking status.
EVALUATION OF DIAGNOSTIC ALGORITHM BASED ON COLLAGEN ORGANIZATION PARAMETERS FOR BREAST TUMORS
Authors: Lukianova N. , Zadvornyi T. , Mushii O. , Pyatchanina T. , Chekhun V. 
Published: February 2023

The changes in the quantitative parameters and spatial structure of collagen are considered a key diagnostic and prognostic factor associated with the development of many malignant neoplasms, including breast cancer (BCa). The aim of the work was to develop and test an algorithm for the assessment of collagen organization parameters as informative attributes associated with BCa for developing technology of machine learning and building an intelligent system of cancer diagnostics. Materials and Methods: Tumor tissue samples of 5 patients with breast fibroadenomas and 20 patients with stage I–II BCa were studied. Collagen was identified histochemically by Mallory method. Photomicrographs of the studied preparations were obtained using a digital microscopy complex AxioScope A1. Morphometric studies were performed using the software CurveAlign v. 4.0. beta and ImageJ. Results: The algorithm for determining the quantitative characteristics and spatial organization of the collagen matrix in tumor tissue samples has been developed and tested. We showed that collagen fibers in the BCa tissue are characterized by significantly lower values of length (p < 0.001) and width (p < 0.001) as well as higher values of straightness (p < 0.001) and angle (p < 0.05) compared to these in the fibroadenoma tissue. No significant difference was found in the density of collagen fibers in the tissue of benign and malignant neoplasms of the mammary gland. Conclusion: The algorithm allows assessing a wide range of parameters of collagen fibers in tumor tissue, including their spatial orientation and mutual arrangement, parametric characteristics and density of the three-dimensional fibrillar network.
DESKRIPSI KECERDASAN EMOSIONAL REMAJA SELAMA SCHOOL FROM HOME (SFH)
Authors: Rezkiki Fitrianola , Kartika Imelda Rahmayunia , Gemilang Fhajri Arye , Fakhri Fakhri , Meiyersi Heru 
Published: February 2023

<p align="center"><strong>Abstrak</strong></p><p><strong>Latar Belakang : </strong><em>Pandemic corona virus disease </em>bukan hanya berdampak pada dunia kesehatan dan ekonomi, tetapi juga dirasakan oleh dunia pendidikan. Terhitung Maret 2020 hingga sekarang, kegiatan pembelajaran tatap muka di sekolah resmi dihentikan sementara, diganti dengan <em>School from Home</em> (SFH). Madrasah Tsanawiyah/sederajat paling banyak mengikuti metode belajar di rumah. Ada 28.587.688 murid yang belajar jarak jaruh. Penutupan dan pembelajaran yang di alokasikan ke rumah menimbulkan dampak terhadap kecerdasan emosional peserta didik. Tujuan penelitian ini adalah untuk mengetahui deskripsi kecerdasan emosional peserta didik selama pembelajaran dirumah (<em>School From Home</em>). <strong>Metode: </strong>Penelitian ini menggunakan desain penelitian kuantitatif dengan pendekatan deskriptif analitik, dengan sampel penelitian ini berjumlah 285 orang yang diambil menggunakan <em>accidental</em><em> sampling</em><em>.</em> Instrumen yang digunakan adalah kuesioner kecerdasan emosional disadur dari Siregar (2018) yakni berisi 30 item pernyataan dengan 24 pernyataan positif dan 6 pernyataan negatif menggunakan skala likert. Kuesioner terdiri atas komponen kecerdasan emosional yang meliputi kesadaran diri, pengaturan diri, motivasi, empati dan keterampilan sosial. <strong>Hasil : </strong>Hasil penelitian ini menunjukkan bahwa sebagian responden (58,25%) memiliki kecerdasan emosional yang rendah, dengan nilai mean terendah terdapat pada komponen Motivasi. <strong>Kesimpulan: </strong>Hasil<strong> </strong>pengkategorisasian skor kecerdasan emosional secara keseluruhan menunjukkan bahwa di MTsN 2 Bukittinggi didominasi oleh peserta didik dengan kecerdasan emosional dengan kategori rendah<strong>, </strong>dimana pada kategori motivasi peserta didik itu sendiri. Hal ini sangat dipengaruhi oleh kondisi pembelajaran dirumah, sehingga diharapkan pihak sekolah mampu meningkatkan motivasi belajar peserta didik walaupun belajar dari rumah masih tetap dilakukan pada kondisi pandemi ini.</p><p><strong>Kata kunci : kecerdasan emosional, peserta didik, <em>school from home</em></strong></p>
PERSEPSI MAHASISWA TENTANG KOMPETENSI PERSEPTOR KLINIK DALAM KEGIATAN PRESEPTORSHIP SELAMA PRAKTEK PROFESI NERS
Authors: Kartika Imelda Rahmayunia , Rezkiki Fitrianola 
Published: February 2023

<p><strong>Abstrak</strong></p><p>Kompetensi perseptor klinik dapat berupa kompetensi klinik maupun komptensi mengajar dalam <em>preceptorship</em>, dimana bertugas memperkuat profesionalisme mahasiswa dengan mendukung perkembangan profesi dan membantu mahasiswa mencapai target kompetensi. Penelitian ini bertujuan untuk mengetahui gambaran kompetensi perseptor dalam hal ini kompetensi klinik (<em>clinical competence</em>) dan Kompetensi Mengajar (<em>Teaching skill</em>) yang dinilai dari persepsi mahasiswa yang sedang menjalani praktek profesi ners di rumah sakit. Penelitian ini menggunakan desain penelitian kuantitatif dengan pendekatan deskriptif analitik. Sampel penelitian ini adalah 30 orang mahasiswa yang sedang menjalani praktek profesi ners. Instrumen yang digunakan adalah kuesioner tentang Kompetensi Preseptor Klinik. Hasil penelitian ini menunjukkan bahwa kompetensi klinik perawat sebagai perseptor klinik dalam kegiatan perseptorship (bimbingan) selama praktek profesi ners adalah baik (50%). Namun, kompetensi mengajar (<em>teaching skill</em>) perseptor klinik masih banyak yang menyatakan kurang baik (66.7%). Penelitian ini menyimpulkan bahwa kompetensi klinik perseptor harus ditingkatkan dengan pengembangan kompetensi klinis para perseptor klinik. Diharapkan organisasi keperawatan memberi dukungan yang cukup dalam kegiatan perseptorship, dan menciptakan suasana belajar yang representatif.</p><p> </p><p>Kata kunci: Kompetensi Perseptor Klinik, Perseptorship, Mahasiswa Ners</p>
PERAN PEMERIKSAAN NON INVASIF DAN PENCITRAAN KARDIOVASKULAR DALAM MANAJEMEN PENYAKIT JANTUNG KORONER
Authors: Mezal Ricky Juliardi 
Published: February 2023

<p><em>Noninvasive cardiac test is a cornerstone of the diagnostic work-up in patients with suspected coronary artery disease (CAD). It is essential for the assessment of CAD and considered the gate-keeper to invasive coronary angiography. Cardiac tests include exercise electrocardiography, single photon emission computed tomography myocardial perfusion imaging, positron emission tomography myocardial perfusion imaging, stress echocardiography, coronary computed tomography angiography, and stress cardiac magnetic resonance. However, clinicians face a challenge when deciding which test is most appropriate for a given patient. Basic knowledge of each modality will facilitate the decision-making process in CAD assessment</em><em>.</em></p>
ANALISIS DETERMINAN IMUNISASI DASAR LENGKAP PADA BAYI DI PUSKESMAS RAWANG DAN PUSKESMAS KOTO LOLO KOTA SUNGAI PENUH TAHUN 2021
Authors: Nopiarti Sriayu 
Published: February 2023

<p>Latar Belakang : Menurut Organisasi Kesehatan Dunia (WHO), pada tahun 2018 ada sekitar 20 juta anak di dunia yang tidak mendapatkan imunisasi lengkap. Salah Satu Indikator keberhasilan Program imunisasi dasar lengkap adalah tercapainya Imunisasi dasar lengkap (IDL) di Indonesia mencapai 86,8% dan perlu ditingkatkan hingga mencapai target 93%. Tujuan penelitian ini untuk mengetahui Analisis Determinan Faktor Imunisasi Dasar Lengkap Pada Bayi Di Puskesmas Rawang Dan Puskesmas Koto Lolo Kota Sungai Penuh Tahun 2021.</p><p>Metode Penelitian menggunakan jenis mixed methods, kuantitaitf menggunakan pendekatan crossectional dan kualitatif menggunakan pendekatan Fenomenologi di lakukan pada bulan Meit-Juli 2021, sampel 300 orang yaitu bayi di Puskesmas Rawang Dan Puskesmas Koto Lolo Tahun 2021 dan informan sebanyak 8 orang. Analisis data dengan Uji Chi Square dan uji regresi logistik ini adalah untuk memperoleh dan mendapatkan deskripsi, analisis, interprestasi serta faktor yang paling berpengaruh terhadap Faktor Imunisasi Dasar Lengkap Pada Bayi Di Puskesmas Rawang Dan Puskesmas Koto Lolo Kota Sungai Penuh Tahun 2021.</p><p>Hasil Penelitian Hasil uji statistik Chi-Square pada pengetahuan (0,000), sikap (0,000), pendidikan 0,020), jarak pelayanan kesehatan (0,000), peran tenaga kesehatan (0,000), pendapatan (0,488), dan pekerjaan orang tua (0,205) maka dapat disimpulkan adanya hubungan pengetahuan, sikap, pendidikan, jarak pelayanan kesehatan, peran tenaga kesehatan dengan Imunisasi Dasar Lengkap Pada Bayi Di Puskesmas Rawang Dan Puskesmas Koto Lolo Kota Sungai Penuh Tahun 2021.</p><p>Kesimpulan Didapatkan faktor yang paling dominan pengaruhnya terhadap Imunisasi Dasar Lengkap pada bayi adalah sikap (p-value 0,000). Input pada penelitian ini sudah tercapai, proses pada penelitian ini sudah berjalan dengan baik hanya saja pada pencatatan dan pelaporan belum terlalu mendetail dan begitu juga dengan pemantauan pendistribusian vaksin ke puskesmas belum terlalu ketat, Dan output pada penelitian ini sudah mencapai target, hanya saja saja ibu yang memiliki anak balita masih ada yang tidak mau anak nya dilakukan imunisasi dasar. Disarankan pada Puskesmas dapat meningkatkan informasi dalam menyusun kebijakan dan strategi program kesehatan terutama yang berhubungan dengan pelayanan kesehatan masyarakat khusus nya program Imunisasi Dasar Lengkap pada bayi dimasa yang akan datang dan model penerapan dengan pendekatan multi strategi seperti pembuatan kantong persalinan, pembuatan group whatsapp, sertifikat imunisasi.</p><p> </p><strong>Kata Kunci : Imunisasi Dasar Lengkap, Pengetahuan, Sikap, Pendidikan, Jarak Pelayanan Kesehatan, Peran Tenaga Kesehatan, Pendapatan, Pekerjaan</strong>
Rapid evaluation of service innovations in health and social care: key considerations
Authors: Smith Judith , Ellins Jo , Sherlaw-Johnson Chris , Vindrola-Padros Cecilia , Appleby John , Morris Stephen , Sussex Jon , Fulop Naomi J 
Published: February 2023

This essay explores the emerging field of rapid evaluation in health and social care, drawing out the ways in which it is distinctive from or similar to other forms of applied research. It draws closely on the experience of two National Institute for Health and Care Research rapid service evaluation teams established in 2018, of which all authors of this essay are members. Reflection on the rapid evaluation teams’ body of work is used to highlight methodological and operational considerations for researchers, practitioners and policy-makers interested in the commissioning, conduct and application of rapid evaluations in health and social care.
The essay is organised according to the ‘evaluation pathway’, from project selection and scoping, stakeholder involvement, research methods and activity, through skills and team working to feedback and dissemination. Its conceptual framing draws on Riley et al.’s rapidity, responsiveness and relevance framework, proposing a fourth dimension of rigour. Novel insights include: the primacy of scoping thoroughly a rapid evaluation; the trade-offs to be made in respect of patient and community engagement and rapid working; the opportunities presented by virtual and mixed research methods; the particular challenges of supervising and leading multiple studies undertaken simultaneously; and the need for flexible and dynamic approaches to disseminating emerging findings in as close to real time. The essay concludes by setting out key lessons about how to conduct rapid evaluations.
Funding
This project was funded by the National Institute for Health and Care Research (NIHR) Health and Social Care Delivery Research programme (RSET: 16/138/17; BRACE: 16/138/31).
SPHINX-Based Combination Therapy as a Potential Novel Treatment Strategy for Acute Myeloid Leukaemia
Authors: Wodi Chigeru , Belali Tareg , Morse Ruth , Porazinski Sean , Ladomery Michael 
Published: February 2023

Introduction: Dysregulated alternative splicing is a prominent feature of cancer. The inhibition and knockdown of the SR splice factor kinase SRPK1 reduces tumour growth in vivo. As a result several SPRK1 inhibitors are in development including SPHINX, a 3-(trifluoromethyl)anilide scaffold. The objective of this study was to treat two leukaemic cell lines with SPHINX in combination with the established cancer drugs azacitidine and imatinib.Materials and Methods: We selected two representative cell lines; Kasumi-1, acute myeloid leukaemia, and K562, BCR-ABL positive chronic myeloid leukaemia. Cells were treated with SPHINX concentrations up to 10μM, and in combination with azacitidine (up to 1.5 μg/ml, Kasumi-1 cells) and imatinib (up to 20 μg/ml, K562 cells). Cell viability was determined by counting the proportion of live cells and those undergoing apoptosis through the detection of activated caspase 3/7. SRPK1 was knocked down with siRNA to confirm SPHINX results.Results: The effects of SPHINX were first confirmed by observing reduced levels of phosphorylated SR proteins. SPHINX significantly reduced cell viability and increased apoptosis in Kasumi-1 cells, but less prominently in K562 cells. Knockdown of SRPK1 by RNA interference similarly reduced cell viability. Combining SPHINX with azacitidine augmented the effect of azacitidine in Kasumi-1 cells. In conclusion, SPHINX reduces cell viability and increases apoptosis in the acute myeloid leukaemia cell line Kasumi-1, but less convincingly in the chronic myeloid leukaemia cell line K562.Conclusion: We suggest that specific types of leukaemia may present an opportunity for the development of SRPK1-targeted therapies to be used in combination with established chemotherapeutic drugs.
The effect of rhamnolipids on fungal membrane models as described by their interactions with phospholipids and sterols: An in silico study
Authors: Rodríguez-Moraga Nely , Ramos-Martín Francisco , Buchoux Sébastien , Rippa Sonia , D’Amelio Nicola , Sarazin Catherine 
Published: February 2023

Introduction: Rhamnolipids (RLs) are secondary metabolites naturally produced by bacteria of the genera Pseudomonas and Burkholderia with biosurfactant properties. A specific interest raised from their potential as biocontrol agents for crop culture protection in regard to direct antifungal and elicitor activities. As for other amphiphilic compounds, a direct interaction with membrane lipids has been suggested as the key feature for the perception and subsequent activity of RLs.Methods: Molecular Dynamics (MD) simulations are used in this work to provide an atomistic description of their interactions with different membranous lipids and focusing on their antifungal properties.Results and discussion: Our results suggest the insertion of RLs into the modelled bilayers just below the plane drawn by lipid phosphate groups, a placement that is effective in promoting significant membrane fluidification of the hydrophobic core. This localization is promoted by the formation of ionic bonds between the carboxylate group of RLs and the amino group of the phosphatidylethanolamine (PE) or phosphatidylserine (PS) headgroups. Moreover, RL acyl chains adhere to the ergosterol structure, forming a significantly higher number of van der Waals contact with respect to what is observed for phospholipid acyl chains. All these interactions might be essential for the membranotropic-driven biological actions of RLs.
Indoxyl sulfate induces left ventricular hypertrophy via the AhR-FGF23-FGFR4 signaling pathway
Authors: Kishimoto Hiroshi , Nakano Toshiaki , Torisu Kumiko , Tokumoto Masanori , Uchida Yushi , Yamada Shunsuke , Taniguchi Masatomo , Kitazono Takanari 
Published: February 2023

BackgroundPatients with chronic kidney disease (CKD) have a high risk of left ventricular hypertrophy (LVH). Fibroblast growth factor 23 (FGF23) and indoxyl sulfate (IS) are associated with LVH in patients with CKD, but the interactions between these molecules remain unknown. We investigated whether IS contributes to LVH associated with FGF23 in cultured cardiomyocytes and CKD mice.Methods and resultsIn cultured rat cardiac myoblast H9c2 cells incubated with IS, mRNA levels of the LVH markers atrial natriuretic factor, brain natriuretic peptide, and β-myosin heavy chain were significantly upregulated. Levels of mRNA of the polypeptide N-acetylgalactosaminyltransferase 3 (GALNT3), which regulates FGF23 O-glycosylation, and FGF23 were also upregulated in H9c2 cells. Intact FGF23 protein expression and fibroblast growth factor receptor 4 (FGFR4) phosphorylation were increased in cell lysates by IS administration. In C57BL/6J mice with heminephrectomy, IS promoted LVH, whereas the inhibition of FGFR4 significantly reduced heart weight and left ventricular wall thickness in IS-treated groups. While there was no significant difference in serum FGF23 concentrations, cardiac FGF23 protein expression was markedly increased in IS-injected mice. GALNT3, hypoxia-inducible factor 1 alpha, and FGF23 protein expression was induced in H9c2 cells by IS treatment and suppressed by the inhibition of Aryl hydrocarbon receptor which is the receptor for IS.ConclusionThis study suggests that IS increases FGF23 protein expression via an increase in GALNT3 and hypoxia-inducible factor 1 alpha expression, and activates FGF23-FGFR4 signaling in cardiomyocytes, leading to LVH.
Changes of serum uric acid level during acute gout flare and related factors
Authors: Zhang Jie , Sun Wenyan , Gao Fei , Lu Jie , Li Kelei , Xu Yijun , Li Yushuang , Li Changgui , Chen Ying 
Published: February 2023

ObjectiveBy studying the changes of serum uric acid (SUA) in acute stage and remission stage of gouty arthritis, we aimed to explore the relationship between the changes of SUA level and free glucocorticoids and inflammatory factors.MethodsA prospective, longitudinal study was conducted on 50 acute gout patients in the dedicated gout clinic of the Affiliated Hospital of Qingdao University. Blood and 24-hour urine samples were collected during the acute phase and two weeks after the initial visit. Patients with acute gouty arthritis were treated primarily with colchicine and nonsteroidal anti-inflammatory drugs.ResultsA total of 32 patients completed the two-week follow-up trial. SUA levels were significantly downregulated during the acute flare than after the flare (464.14 ± 90.97 vs. 527.36 ± 86.90 μmol/L, p &lt; 0.001). The 24-hour fractional excretion of uric acid (24 h FEur) (5.54 ± 2.82% vs. 4.68 ± 2.83%, p &lt; 0.001) and 24-hour urinary uric acid excretion (24 h Uur) (663.08 ± 249.48 μmol/L vs. 540.87 ± 263.18 μmol/L, p = 0.001) increased significantly in patients during the acute phase. The percent change in SUA was associated with those in 24 h FEur and C-reactive protein. Meanwhile, the percent change in 24 h Uur was associated with those in 24-hour urinary free cortisol, percent change in interleukin 1β and interleukin 6.ConclusionDecreased SUA level during the acute gout flare was associated with increased excretion of urinary uric acid. Inflammatory factors and bioactive free glucocorticoids may play significant roles in this process.