bluuebunny/crossref_metadata_2025_split huggingface dataset:
Simulation of crack nucleation in materials with regularly arranged spherical pores under multiaxial loading conditions
Authors: Zabolotsky A. V. , Migashkin A. O. , Grigor'ev A. S. , Dmitriev A. I. , Turchin M. Yu. , Khadyev V. T. , Shil'ko E. V. 
Published: June 2023

A numerical study of the initial stage of crack growth in a material containing spherical pores under multiaxial compression (constrained conditions) has been carried out using the finite element method. The influence of the pore spacing and the mechanical properties of the material on the fracture localization and the direction of crack growth has been analyzed. Both brittle and ductile materials were studied. It has been established that material properties and the mutual arrangement of defects have a significant influence on the direction of propagation of cracks arising on the stress concentrators (structure defects), up to mutually perpendicular directions (for uniaxial of the characteristic sizes of the region of influence of spherical pores on each other, beyond which the stress fields of the neighboring elements of the structure do not overlap. The dependences of the sizes of this area on the elastic characteristics of the matrix material are shown. The obtained results are relevant for obtaining numerical estimates of the duration of the initial stages of quasi- brittle fracture of ceramic-based heterophase materials, refractories in particular. Ill. 6. Ref. 26. Tab. 1.
Dependence of the formation of the five-layer Aurivillius phase on the chemical prehistory of the Initial composition
Authors: Lomanova N. A. , Tomkovich M. V. , Ugolkov V. L. 
Published: June 2023

Materials with a layered perovskite-like structure of the Aurivillius phase type are important for such fields of technology as magnetoelectronics and photocatalysis. The paper describes the features of phase formation during the synthesis of nano- and macrocrystalline materials based on the Bi6Fe2Ti3O18/ 8 compound with the five-layer Aurivillius phase structure. Samples were characterized by powder XRD, DSC/TG, dilatometry, SEM/EDX. The temperatures of the beginning of formation, the Curie point, the beginning of decomposition and activation of sintering of the obtained materials, as well as the value of the linear thermal expansion coefficient were determined. The technological possibility of controlling the dispersion of the obtained materials by changing the synthesis conditions is shown. Ill. 5. Ref. 20. Tab. 1.
UNIVERSAL HYDROGAS-DYNAMIC PATTERNS OF THE DRAINAGE ZONE OF OIL AND GAS WELLS
Authors: Ibrahimli T.H. 
Published: June 2023

Large-scale experimental hydrogasodynamic studies of the flow of a two-phase gas-liquid mixture in a vertical pipeline were carried out. Based on the analysis of the results of these experimental studies, it was found that among the results obtained there are dependencies with theoretical bases by which theoretical hydrogasodynamic methods for studying multiphase flow in a vertical pipeline can be developed. The article provides a theoretical hydrogasodynamic study using dependencies describing a two-phase flow in a vertical pipeline of a round section, and it is confirmed by existing experiments. As a result of the gas-hydrodynamic study of pumping wells, in order to confirm the rational use of formation gas energy, a positive effect due to an increase in oil production rate and well process parameters, a relationship was established between well Q production rate, bottom-hole pressure of well P and production of formation gas V. Parameters can be modeled using three-term polynomials. During operation of wells in three modes (Qi, Vi or ∆Pi,Vi, where i = 1,2,3), processing of data obtained as a result of studies, indicators determined by existing research methods were obtained, and the technological mode ensuring layer-bylayer cooperation of the well system was selected.
It is known that the motion of a two-phase flow of gas-liquid mixtures in a vertical pipe string is described on the basis of energy balance theory. The hydrogasodynamic characteristics of the drainage zone can be obtained in a real oil and gas well, as an experimental installation in the form of
The Spacialization Revisited: Extensive Type’s Characterization and Contradictions in Theodor W. Adorno
Authors: Andrade João Paulo 
Published: June 2023

As Adorno’s posthumous writings were released, a notable turn in his philosophy of music became noteworthy: by revealing an ambitious project on Beethoven, a quasi-axiomatic theory of musical time emerged, which seems to guide adornian thought at very significant works and texts, as Philosophy of New Music. Sketched in three configuration types of musical time, this theory surprises with the so-called “extensive type”. Adorno would then admit kinds of formal consistency (Stimmigkeit) that are not restricted to the ideal of development (Entwicklung) and assumes the possibility of a non-regressive spatialization, which contrasts with his own ontological definition of the medium. This paper discusses the contradictions of extensive type by presenting an analysis of the Archduke Trio op. 97, in the light of the well-known originary affinity between Beethoven and Hegel. At last, the text presents by which means and for what reasons the extensive type would lead Adorno to the last and most decisive modality of musical time’s configuration, the late style.
Hipotiroidismo refractario al tratamiento
Authors: Pantoja-Rosero María Elena , Lara-Viáfara Melissa Fernanda , Builes-Barrera Carlos Alfonso 
Published: June 2023

Introduction: Refractory hypothyroidism is an entity in which patients require high doses of thyroid hormone, persisting with symptoms of hypothyroidism and high thyroid stimulating hormone (TSH) levels, representing a challenge for the clinician. Understanding its causes allows a better diagnostic approach and avoids overdosage and adverse effects.
Objective: To present key concepts to help identify the causes of refractoriness to treatment, including adherence, malabsorption, or increased thyroid hormone demand.
Methods: A search of the main concepts about the causes, diagnosis and treatment of refractory hypothyroidism was performed, according to the review presented at the congress of the Colombian Association of Internal Medicine (ACMI) on May 13 and 14, 2022.
Results: Persistent TSH elevation in patients receiving thyroid hormone supplementation may be present in up to 30% of patients with hypothyroidism. The most frequent cause is poor adherence to treatment, followed by malabsorption and increased demand for the drug. The diagnostic approach should be sequential to find the cause, in some performing specialized studies to rule out malabsorption.
Conclusions: Identifying the causes of refractory hypothyroidism to treatment are key to have an adequate symptomatic and clinical control of the pathology, and likewise avoid the use of supratherapeutic doses of levothyroxine, since it is related to major adverse effects at cardiovascular and bone level.
Wykorzystanie czasopism gromadzonych przez PBP Książnicę Pedagogiczną im. A. Parczewskiego w Kaliszu – raport z badań
Authors: Pomiecińska Róża 
Published: June 2023

W artykule opisano wyniki badań ankietowych dotyczących wykorzystania czasopism gromadzonych przez Książnicę Pedagogiczną im. A. Parczewskiego w Kaliszu przez nauczycieli, studentów oraz użytkowników biblioteki. Autorka artykułu zwróciła uwagę m.in. na sposoby promocji periodyków, a także wskazała działania mające służyć lepszemu wykorzystaniu czasopism znajdujących się w zasobach kaliskiej biblioteki.
Student-on-teacher violence in South Africa’s Tshwane South District of Gauteng Province: Voices of the victims
Authors: Venketsamy Roy , Baxen Elaine , Hu Zijing 
Published: June 2023

School violence is a growing concern globally and schools in South Africa find it difficult to manage the problem of learner behaviour. Despite various educational policies and frameworks developed to prevent school violence, the system continues to fail teachers. Due to violence, schools are no longer safe places for teachers and learners. In South Africa, teachers are regularly exposed to physical violence and verbal attacks by learners. Recent media reports about teachers being attacked by learners clearly show an intent to inflict severe physical harm on the teacher. This qualitative study was conducted in one province in South Africa underpinned by the National School Safety Framework. This qualitative study aimed to understand the lived experience of teachers who had experienced violence against them by learners. The findings revealed that teachers are experiencing social, emotional and psychological trauma. Many teachers cannot perform their duties fruitfully and are constantly anxious to go to school. Emanating from this study, the following recommendations have been proposed: the Department of Education in South Africa should enforce its numerous policies and guidelines to protect teachers against violence. Social and psychological support services should be made available to teachers who have experienced violence. A stricter disciplinary code of conduct should be implemented in all schools for learners.
Chimeric provirus of bovine leukemia virus/ SMAD family member 3 in cattle with enzootic bovine leukosis
Authors: Nao Naganori , Okagawa Tomohiro , Nojiri Naomi , Konnai Satoru , Shimakura Honami , Tominaga Misono , Furihata Hazuka Yoshida , Nishiyama Eri , Matsudaira Takahiro , Maekawa Naoya , Murata Shiro , Muramatsu Masamichi , Ohashi Kazuhiko , Saito Masumichi 
Published: June 2023

Abstract
Bovine leukemia virus (BLV) is a member of the family Retroviridae and causes enzootic bovine leukemia (EBL). However, the association between BLV infection and EBL development remains unclear. In this study, we identified a BLV/SMAD3chimeric provirus within CC2D2A intron 30 in monoclonal expanded malignant cells from an EBL cow. The chimeric provirus harbored a SMAD3spliced sequence composed of exons 3–9 encoding the short isoform protein, and the BLV-SMAD3chimeric transcript was detectable in EBL cattle. This is the first report of a BLV chimeric provirus that might be involved in EBL tumorigenesis.
The rise of income inequality in OECD countries: is globalization one of the causes?
Authors: Cívico Juan Carlos Palacios , Kern Andreas , Gorjón Lucía 
Published: June 2023

Abstract

The current work aims to contrast the impact of globalization on income inequality in OECD countries through the estimation of a Panel Vector Autoregression Model (PVAR). This methodology allows to explain both the direct and indirect mechanisms whereby globalization could increase income inequality, as well as their duration. The results point out that besides the direct and positive impact of globalization on income inequality, there is an indirect or second-round impact coming from the effect of globalization on the compensatory institutions which traditionally contributed to build more egalitarian societies. As suggested by Rodrik (1998), however, the analysis does not appear to confirm the race to the bottom hypothesis by identifying a positive correlation between globalization and the redistributive capacity of states.
Development and application of parametric design system for solid end mills based on Open CASCADE
Authors: Lin Zhi , Yue Caixu , Liu Xiaodong , Liu Xianli , Yu Zhongguang , Hu Desheng , Zhang Qianyi 
Published: June 2023

Abstract
The traditional commercial CAD software is well developed and powerful, and has been widely used in the design of integral end mills. With the development of tool design towards system integration, designers put forward the requirements of specialization and lightweight for CAD software. The secondary development of CAD software has become the main development direction, which can realize the integration of CAD, CAM and CAE software. However, due to factors such as kernel and interface, the effect of this integration is limited and the secondary development can no longer meet the current needs of rapid and accurate tool design. Therefore, the development of an independent CAD software is more conducive to the integration of tool design systems. In order to build a lightweight and easy integrated cutting tool CAD software, this paper implements the parametric design of solid end mill based on Open CASCADE. Using Python as the underlying language and Python OCC modeling interface and model visualization function, the parametric design system of solid end mill is established. The system can quickly and accurately generate data files, 2D graphics and 3D models conforming to ISO13399 standard, and realize the cloud storage function of model data. The generated tool model data can be used for finite element simulation of cutting process, NC programming and connection with tool manufacturing module. Based on the established system, the centroid optimization of the imbalance characteristics of the variable pitch and helix solid end mill was carried out, and the dynamic balance of this type of cutter was improved. The establishment of the system provides a reference value for the development of other types of cutting tool parametric design systems.
Design and Implementation of a Virtual Instrument-Based Seismic Reflection Wave Imaging System
Authors: Lu Peng , Yu Meijiao , Zhang Renyong 
Published: June 2023

Abstract
This paper presents a seismic reflection wave imaging system that uses virtual instrumentation technology to process seismic wave data. The system employs a modular approach to image reflection waves in a medium velocity hierarchy. The study investigates the time and frequency domain characteristics of seismic sub-waves transmitted in the reflection system and establishes and simulates the propagation model of seismic reflection waves in horizontally stratified media. Algorithms are proposed for implementing the overall system, including amplitude compensation, digital filtering, velocity analysis, and offset imaging. The effectiveness of 2D FK filtering in the filtering process is tested, which confirms its ability to filter out velocity domain interference waves. The hardware and software development solutions for the overall system are developed based on the architecture of virtual instrumentation technology. Seismic reflection wave imaging experiments are conducted in several scenarios, and the experimental results meet the application requirements. The experiments demonstrate that the system can accurately image the velocity of subsurface media using seismic reflection waves and virtual instrumentation hardware and software systems.
Regional staining reverse time migration algorithm based on energy-constrained factors
Authors: Liu Chang , Qu Yingming , Li Zhenchun , Zeng Shenghan , Yang Tingyu , Zhao Weijie 
Published: June 2023

Abstract

Stained migration algorithms can improve the imaging result in some special structures, such as subsalt layers and steeply inclined layers, by introducing the complex domain. Conventional stained migration algorithms need to stain the target geological body precisely. However, in actual production, it is not possible to stain only the target geological body, which leads to inaccurate stained imaging results. So we propose a new regional staining algorithm based on energy-constrained factors. Derive the discrete form of the complex domain wave equation and the imaging formula of the imaginary migration result. Study the influence of the stained region boundary on seismic wave propagation when different migration velocities are input. Based on the difference in energy of the reflected waves generated at the stained region boundary and those generated by the target geological body, we propose positive and negative energy-constrained factors to constrain the interference waves by stained boundaries. The positive energy-constrained factor can filter out weak interference waves, and the negative energy-constrained factor can filter out strong interference waves. Numerical examples of a simple three-layer horizontal model and a complex salt model show that the new regional staining algorithm based on energy-constrained factors can increase the illumination of the target geological body and improve the imaging resolution of the target region, even when stained areas are imprecise.
Air quality during 2010-2020 over two mega cities in the west zone of India- with special reference to COVID-19 lockdown.
Authors: Nehul Shashikant , Rohra Himanshi , Rutgersson Anna , Satsangi Gursumeeran , G Krishnakumar , Murari Vishnu , Talokdar Shamitaksha , Gadgil Alka 
Published: June 2023

Abstract

With the advent of industrialization in the world's major metropolitan areas, air pollution has steadily increased. Several strict laws are imposed by the authorities to minimize the impact of pollution in urban dwellings. The lockdown restrictions during COVID-19 pandemic resulted in major air quality improvements worldwide. However, episodic improvements in air quality understates explicit picture of air quality. This merits the cause for spatio-temporal analysis of air quality over two most affected metropolitan regions in west India: Pune and Mumbai, in the past decade. We investigated the air quality by collecting hourly primary data of PM10, SPM, SO2, and NOx at three locations in Pune while daily data of PM10, SO2, and NOx was obtained at eleven locations in Mumbai. As the data were copiously available (2010–2020), decadal, inter-intra seasonal analysis was carried out at multi-timescales. This contributed in intensively exploring the variations in 2020 resulting in critical evaluation during the pandemic year. Against the overall deterioration in air quality in the past decade, finer refinement in air quality was witnessed over Pune during the lockdown. At Mumbai, an overall reduction of 59% was observed at all the locations. In both the cities, the pollution behaviour varied on a spatio-temporal scale within the cities. The study, therefore, infers the distinctiveness of pollutant behaviour on a spatial scale within the city rather than overall average for the city. It also recommends strengthening the air monitoring network in urban dwellings to track varied sources and formulate precise urban planning.
Trichoderma and sodium nitroprusside elicitation improves vinblastine and vincristine yield by increasing TIA pathway genes expression in cell suspension of Catharanthus roseus
Authors: Farzaei Leila , Sayyari Mohammad 
Published: June 2023

Abstract
Biotic and abiotic elicitors induce the production of plant secondary metabolites. In this study the effects of Trichoderma harzianum and sodium nitroprusside (SNP) as a biotic and abiotic elicitor on biochemical and molecular features of Catharanthus roseous cell suspension were investigated. Leaf explant and medium amended with concentration of 8 µM 2,4-D and 2 µM BAP were used for obtain cell suspension. Cell suspension exposed to T. harzianum. (%1 v/v) and SNP (150 µM) and after 12, 24, 48 and 72 hours harvested. The highest activity of catalase, ascorbate peroxidase, β (1–3) glucanase and chitinase were found 48 hours after application of treatments. Also, the highest level of G10H (2.5-fold), T16H (1.5-fold), D4H (1.1-fold), DAT (1.9-fold), STR (5-fold) and CrPRX (2-fold) were observed 48-hours after elicitor application. A positive correlation was observed between enzymes activities, TIAs biosynthesis pathway genes and vinblastine and vincristine accumulation. These results confirmed that fungus and SNP elicitors in C. roseous led to increase secondary metabolites production and gene expression related to biosynthesis of vinblastine and vincristine pathway 1.84 and 1.93-fold, 48-hours after elicitor application, respectively. All these results suggest that fungus and SNP elicitors after 48-houres exposure, effectively improve the pharmaceutical value of C. roseous.
Phase II study of S-1 plus docetaxel as first-line treatment for older patients with advanced gastric cancer (OGSG 0902)
Authors: Kawase Tomono , IMAMURA HIROSHI , Kawabata Ryohei , Matsuyama Jin , Nishikawa Kazuhiro , Yanagihara Kazuhiro , Yamamoto Kazuyoshi , Hoki Noriyuki , Kawada Junji , Kawakami Hisato , Sakai Daisuke , Kurokawa Yukinori , Shimokawa Toshio , Satoh Taroh 
Published: June 2023

Abstract
Background
Although there is insufficient evidence for the treatment of older patients with advanced gastric cancer, fluorouracil combined with platinum chemotherapy has been recognized as a standard first-line treatment for such populations in Japan despite the lack of efficacy and toxicity data.
Methods
Patients aged 75 years or older with advanced gastric cancer were enrolled. S-1 plus docetaxel (docetaxel: 40 mg/m2, day 1; S-1: 80 mg/m2, days 1–14; q21 days) was repeated every 3 weeks. The primary endpoint was overall response rate. Secondary endpoints were safety, progression-free survival, time to treatment failure, and overall survival. The sample size was calculated as 30 under the hypothesis of an expected response rate of 40% and a threshold response rate of 20%, at a power of 90% and a two-sided alpha value of 5%.
Results
From February 2010 to January 2015, 31 patients were enrolled and assessed for efficacy and toxicity. The response rate was 45.2% (95% CI: 27.3–64.0%; p = 0.001) and it exceeded the expected response rate set at 40%. Median progression-free survival was 5.8 months, the 1-year survival rate was 58.1%, and the median survival time was 16.1 months. The major grade 3/4 adverse events were neutropenia (58%), febrile neutropenia (13%), anemia (10%), anorexia (10%), and fatigue (6%).
Conclusions
These findings indicate that S-1 plus docetaxel as first-line treatment for older patients is feasible and that it has promising efficacy against advanced gastric cancer.
Cuticular chemical composition as a tool for the identification of puparial cases of some forensically important Egyptian blow flies
Authors: Zaher Eman E. , Rashed Salwa S. , Abdel-Halim Fatma A. , Mohammed Samar M. , Salem Abeer Mohsen 
Published: June 2023

Abstract

Cuticular chemical compounds for many insect species were proven to be unique and species specific. Because of their uniqueness, analysis of such chemical profiles, especially cuticular hydrocarbons was used for many purposes including identification of insects. Blow flies are one of the first flies that reach corpses so play a significant role in estimating the minimum post mortem interval. Accurate estimation depends on precise identification of the collected specimens. When only damaged empty puparial cases were left behind, morphological and even molecular identification methods of blow flies is so problematic. The aim of this study was to analyze the chemical compositions of the puparial exuviae ofLucilia sericata, Chrysomya albicepsandChrysomya marginalisusing gas chromatography/mass spectrometry (GC–MS) to evaluate their accuracy in Dipteran identification. Adults were collected from Giza and Cairo Governorates and reared under laboratory conditions until emergence of first-generation adults to obtain their empty puparial cases. GC–MS was used to analyze the chemical composition of these exuviae. Twelve classes of chemical compounds were identified from the three species at retention times 18.78 to 35.03. Alcohol represented the highest percentage (28.6%) of compounds inLucilia sericataprofile. Meanwhile, alkanes (n-alkanes, branched alkanes and cycloalkanes) constitute the major cuticular components of the three fly species with the highest percentage inChrysomya marginaliscuticle. These findings could be considered as a preliminary step toward using hydrocarbon composition as a feasible tool for differentiation between forensic species in Egypt.