bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of Garbage Enzyme as a Bioremediation Method for the Wastewater Treatment
Authors: Singh Anoop Narain , Ray Maya Rajnarayan , Mishra Umank , Jethwa Kruti B. , Yadav Nishant , Shankhwar Nisha , Chauhan Gulab Singh , Meshram Kundan 
Published: January 2025

ABSTRACTThis study evaluates the efficacy of garbage enzyme (GE) in bioremediation to reduce pollutants in sewage drains that discharge into the natural streams and rivers. Garbage enzyme is prepared with help of brown sugar, fruit, vegetable wastes, and water in the proportion 1:3:10 (by weight), which is then applied to the samples collected from various drainage sites in Jaunpur district, Uttar Pradesh, India. Different concentrations of GE (ranging from 0% to 20%) are mixed with sewage to assess pollution reduction. Different parameters, that is, pH, dissolved oxygen (DO), total suspended solids (TSS), total dissolved solids (TDS), biochemical oxygen demand (BOD), chemical oxygen demand (COD), and CD have been measured on 3rd, 5th, 7th, 10th, 15th, and 20th days. It has been observed in the study that significant percentage reduction in BOD, COD, TSS, and TDS of 80.6%, 62.9%, 74.29%, and 43.9%, respectively, while an increase in DO is 67.8% on 20th day of experiment with 20% GE addition. The result of the study reveals that there is highest reduction occurring on the 20th day with a 20% GE concentration. It has been observed that the GE possesses protease, amylase, and lipase activity. Meaning GE contains microorganisms that breakdown carbohydrates, fats, and proteins and it hydrolyzes these complex organic molecules into simpler compounds, making them more readily biodegradable and that is the reason for substantial reduction in the pollutants. Moreover, in this study it has been observed that there is a notable decrease in foul odor emanating from the samples. Time‐dependent fluctuations in pH, TDS, DO, BOD, COD, and temperature are documented, with their correlations examined. This investigation underscores GE's potential in pollution mitigation, particularly in sewage systems, and offers valuable insights for sustainable environmental management practices aimed at conserving natural water bodies. Further tests are required to check the efficiency of treatment with GE dosage higher than 20%.
The potential of deep learning in improving K‐12 students' writing skills: A systematic review
Authors: Bal Mazhar , Öztürk Emre 
Published: January 2025

AbstractThe purpose of this study is to examine the relationship between technology‐supported writing instruction at the K‐12 level and deep learning approaches and to understand the trends in this field. In the study, 12 articles selected from Web of Science, Scopus, ERIC and EBSCO databases were systematically analysed. The findings reveal that the methods differed in teaching writing, with the use of educational technologies varying according to educational level. While authentic learning environments were created with SVVR technology in primary school, artificial intelligence (AI)‐supported assessment systems were used in secondary school and AI literacy and interdisciplinary approaches gained importance in high school. The diversity of research methods and the use of multiple data collection tools show that educational technology research has become more in‐depth and comprehensive. The effectiveness of technology‐supported writing processes varies according to students' cognitive development levels: in primary school, virtual and augmented‐reality technologies improve writing performance; while in secondary school, AI‐supported systems improve analytical thinking skills. In high school, NLP technologies and interdisciplinary applications strengthen higher‐order thinking skills and writing abilities. At all levels, peer collaboration and feedback stand out as critical elements that support deep learning. The selection and application of educational technologies in accordance with students' cognitive development levels play an important role in determining the success of writing processes.
Exploring South Asian American Identities, Acculturation, Contexts and the Intersections of Mental and Physical Health: A Scoping Review
Authors: Raval Vaishali V. , Banerjee Meeta , Patel Puja , Gandhi Ritika , Durazi Amaesha , Subrahmanyam Kaveri , Mistry Rashmita S. 
Published: January 2025

ABSTRACTDespite being the second largest Asian immigrant group in the United States, South Asian Americans are highly underrepresented in the psychological literature. Considered a ‘model minority’, South Asian Americans are a target of discrimination based on their Brown identity and religious affiliations, making it critical to examine their experiences. Extending the integrated conceptual framework to research pertaining to South Asian Americans published from 2012 to 2022, the aim of this scoping review was three‐fold: (i) to identify the demographics of South Asian Americans included; (ii) to identify whether there was discussion or assessment of contexts of emigration and settlement, religious or sociocultural values or beliefs, and individual interpretive processes or everyday activities; and (iii) to identify which aspects of psychological functioning are studied. Utilising PsycInfo, Scopus, and EBSCO, 103 publications met the inclusion criteria and were reviewed. Indian Americans were the most studied subgroup. Acculturation and physical/mental health, or relationships, parenting, and identity were frequently studied domains. The review highlights the critical need for future studies to examine the diversity of South Asian American experiences, assess relevant contexts, beliefs, values and worldviews and explore individual meaning‐making processes using culturally sensitive methods. Please refer to the Supporting Information section to find this article's community and social impact statement.
46, XY Complete Gonadal Dysgenesis (Swyer Syndrome) Presenting as Primary Amenorrhea in a Normomorphic Adult Female From Kakamega, Kenya
Authors: Omoaghe Christian 
Published: January 2025

ABSTRACTDifferences/disorders of sex development (DSDs) are a diverse group of congenital conditions that result in disagreement between an individual's sex chromosomes, gonads, and/or anatomical sex. The 46, XY DSD group is vast and includes various conditions caused by genetic variants, hormonal imbalances, or abnormal sensitivity to testicular hormones, leading to varying degrees of under‐virilization. A 19‐year‐old phenotypically normal female from Kakamega, Kenya, presented with primary amenorrhea. Physical examination revealed Tanner stage 3 breast development, Tanner stage 4 pubic hair, normal external genitalia, and a gynoid body shape. Hormonal profile tests indicated hypergonadotropic hypogonadism with normal 17‐hydroxyprogesterone and testosterone levels. MRI revealed a hypoplastic uterus and absent ovaries. Karyotyping confirmed a 46, XY genotype, leading to the diagnosis of 46, XY complete gonadal dysgenesis (Swyer syndrome). Swyer syndrome is a rare disorder of sex development, characterized by unambiguous female genitalia, bilateral streak gonads, and elevated gonadotropin levels in individuals with a 46, XY karyotype. The condition results from abnormal gonadal development due to mutations in testis‐determining factors, most commonly the SRY gene. Patients typically present with primary amenorrhea and seldom have secondary sexual characteristics as this patient had. Management includes hormone replacement therapy and gonadectomy because of the increased risk of gonadal tumors. The patient was educated about her condition, initiated on combined contraceptive pills, and counseled on exploratory laparoscopic gonadectomy. This case highlights the importance of a comprehensive diagnostic approach in patients with primary amenorrhea, keeping in mind that patients with disorders of sex development may have developed secondary sexual characteristics.
A probabilistic approach to estimating timber harvest location
Authors: Truszkowski Jakub , Maor Roi , Yousuf Raquib Bin , Biswas Subhodip , Chater Caspar , Gasson Peter , McQueen Scot , Norman Marigold , Saunders Jade , Simeone John , Ramakrishnan Naren , Antonelli Alexandre , Deklerck Victor 
Published: January 2025

AbstractDetermining the harvest location of timber is crucial to enforcing international regulations designed to protect natural resources and to tackle illegal logging and associated trade in forest products. Stable isotope ratio analysis (SIRA) can be used to verify claims of timber harvest location by matching levels of naturally occurring stable isotopes within wood tissue to location‐specific ratios predicted from reference data (“isoscapes”). However, overly simple models for predicting isoscapes have so far limited the confidence in derived predictions of timber provenance. In addition, most use cases have limited themselves to differentiating between a small number of predetermined location options. Here, we present a new analytic pipeline for SIRA data, designed to predict the harvest location of a wood sample in a continuous, arbitrarily large area. We use Gaussian processes to robustly estimate isoscapes from reference wood samples, and overlay with species distribution data to compute, for every pixel in the study area, the probability of it being the harvest location of the examined timber. This is the first time, to our knowledge, that this approach is applied to determining timber provenance, providing probabilistic results rather than a binary outcome. Additionally, we include an active learning tool to identify locations from which additional reference data would maximize the improvement to model performance, allowing for optimisation of subsequent field efforts. We demonstrate our approach on a set of SIRA data from seven oak species in the United States as a proof of concept. Our method can determine the harvest location up to within 520 km from the true origin of the sample and outperforms the state‐of‐the‐art approach. Incorporating species distribution data improves accuracy by up to 36%. The future sampling locations proposed by our tool decrease the variance of resultant isoscapes by up to 86% more than sampling the same number of locations at random. Accurate prediction of harvest location has the potential to transform worldwide efforts to enforce anti‐deforestation legislation and protect natural resources.
Remote patient monitoring in heart failure: A comprehensive meta‐analysis of effective programme components for hospitalization and mortality reduction
Authors: De Lathauwer Ignace L.J. , Nieuwenhuys Wessel W. , Hafkamp Frederique , Regis Marta , Brouwers Rutger W.M. , Funk Mathias , Kemps Hareld M.C. 
Published: January 2025

AbstractAimsMethods of non‐invasive remote patient monitoring (RPM) for heart failure (HF) remain diverse. Understanding factors that influence the effectiveness of RPM on HF‐related and all‐cause hospitalizations, mortality, and emergency department visits is crucial for developing successful RPM interventions. This meta‐analysis aims to synthesize and compare existing literature on RPM components that impact HF‐related and all‐cause hospitalizations, mortality and emergency department visits in HF patients.Methods and resultsA systematic search of electronic databases (PubMed, EMBASE, CENTRAL) identified randomized controlled trials from January 2012 to June 2023, comparing non‐invasive RPM interventions for HF with usual care. A random‐effects meta‐analysis assessed outcomes, and additional analyses identified effective RPM components. A total of 41 studies with 16 312 patients (mean follow‐up: 9.88 ± 6.37 months) were included. RPM was associated with lower mortality risk (pooled odds ratio [OR] 0.81 95% confidence interval [CI] 0.69–0.95; I2 = 0.39) and reduced first HF hospitalization risk (pooled OR 0.78, 95% CI: 0.70–0.87; I2 = 0.21) compared to usual care. RPM interventions with a self‐management module (p < 0.001) and education module (p = 0.028) significantly lowered HF‐related hospitalizations. Video calls during RPM interventions further reduced HF‐related (p = 0.047) and all‐cause hospitalizations (p < 0.001).ConclusionThis meta‐analysis confirms the efficacy of RPM in reducing HF‐related hospitalizations and mortality. Effective components include self‐management, education modules, and video communication. However, heterogeneity among interventions challenges the overall evaluation. Modernizing RPM with advanced technologies like non‐invasive sensors, artificial intelligence, and cardiac telerehabilitation could enhance its potential.
Clinicians' Experiences of Eating Disorder Focused Family Therapy With Autistic Young People
Authors: Duffy Fiona , Peebles Imogen , Clark Emma , Loomes Rachel , Thomson Lisa , Maloney Ellen , Nimbley Emy 
Published: January 2025

ABSTRACTObjectiveEating disorder focused family therapy (FT‐ED) is the leading outpatient intervention for adolescents with Anorexia Nervosa. Autistic people report poorer eating disorder treatment experiences and may be at increased risk of inpatient admissions. There is a need to consider adaptions to eating disorder treatment for this population. The aim of this study is to explore the experiences of clinicians in the delivery of FT‐ED for Autistic young people with Anorexia Nervosa and any adaptations currently being implemented.MethodFT‐ED trained clinicians who had experience of delivering this modality with young Autistic people and their families, were invited to take part in interviews. Transcripts were analysed using Reflexive Thematic Analysis.ResultsEleven clinicians completed interviews and analysis generated four themes and eight subthemes: (1) Systemic context, (2) Raising potential autism, (3) Autism eating disorders crossover, (4) Manual versus adaptations.ConclusionsThis paper is the first exploration of clinician's experience delivering FT‐ED to Autistic young people and their families and highlighted unique considerations with this population. It is an initial step to consider adaptations to the FT‐ED model, with the aim of making eating disorder treatments more effective, accessible and acceptable for Autistic young people and their families.
A Bibliometric Analysis on the Risk Factors of Cancer
Authors: Chen Shan , Ding Yuanzhao 
Published: January 2025

ABSTRACTGiven the high lethality of cancer, identifying its risk factors is crucial in both epidemiology and cancer research. This study employs a novel bibliometric analysis method, which uses the tidytext package and tidy tools in R. This approach surpasses traditional tools like VOSviewer, offering more comprehensive and complex keyword data and clearer results compared to Bibliometrix. By using R, researchers can efficiently handle useful keywords, ignore irrelevant terms, adjust specific settings, and correct errors such as repeated evaluations. This study examines 1000 articles sourced from the Web of Science database, using advanced bibliometric tools like R Studio to analyze publication quantity, frequency, and word co‐occurrences. The primary goal is to uncover key risk factors associated with cancer and explore the underlying mechanisms that link these factors to cancer development. Risk factors are categorized into exogenous (environmental exposures and lifestyle choices) and endogenous (genetic predispositions and hormonal imbalances). By providing a comprehensive analysis of these factors, the study aims to deepen our understanding of cancer risk. This research contributes valuable insights to the broader field of cancer research and has the potential to inform future studies and strategies for cancer prevention and treatment.
Water carrier volume minimally affects fungicide efficacy against pink snow mold of turfgrass
Authors: Hockemeyer K. , Koch P. L. 
Published: January 2025

AbstractSnow mold diseases of turfgrass are an economically important and damaging complex of diseases in areas with persistent snow cover. Traditionally, control is best achieved with fungicide applications made before snow cover, and water carrier volume is one of the variables of a fungicide application that may impact efficacy. Fungicides from all phytomobility groups were applied to fairway height turf at three levels of water carrier volume (204, 407, and 611 L H2O ha−1) before snowfall in late fall over six winters from 2017 to 2023. There was no statistically significant effect of water volume on the efficacy of each fungicide on snow mold control during any of the winters. In some cases, decreasing the water carrier volume did decrease the effectiveness of the fungicide application on snow mold control, but it was not statistically significant. These effects appeared more frequently with the contact fungicides that were tested than any local or acropetal penetrant fungicides included in the study.
Polydopamine‐Induced BMP7‐Poly (Lactic‐Co‐Glycolic Acid)‐Nanoparticle Coating Facilitates Osteogenesis in Porous Tantalum Scaffolds
Authors: Ao Yu , Jiang Dianming 
Published: January 2025

ABSTRACTBone defects are difficult to treat clinically and most often require bone grafting for repair. However, the source of autograft bone is limited, and allograft bone carries the risk of disease transmission and immune rejection. As tissue engineering technology advances, bone replacement materials are playing an increasingly important role in the treatment of bone defects. Porous tantalum (PT) scaffolds have shown beneficial clinical effects in the repair of bone defects, surface modification of PT to induce osteogenic differentiation of mesenchymal stem cells (MSC) is the key to optimizing this material. Poly (lactic‐co‐glycolic acid) nanoparticle (PLGA NPs) encapsulating bone morphogenetic protein 7 (BMP7) (BPNPs) was prepared by a double emulsion (water/oil/water [W/O/W]) method and adhered on polydopamine (PDA)‐coated PT (PPT) that was prepared by biomimetic method to prepare BPNPs‐coated PPT (BPPT). The successful preparation of BPPT was monitored by scanning electron microscopy (SEM) and energy spectrum. Murine calvarial preosteoblasts (MC3T3‐E1) cells were co‐cultured with BPPT, vitro experiments showed that BPPT promoted cell proliferation and osteogenic differentiation. BPPT was further implanted into the bone defect of the distal femoral epiphysis of the rabbit. At 4 weeks postoperatively, in the BPPT group, high‐resolution CT reconstruction indicated that bone volume/total volume (BV/TV) was near 50%, and the hard tissue section indicated that the depth of new bone ingrowth into the scaffolds was nearly 2 mm. The immunofluorescence staining of bone tissue around the bone defects indicated that the expression of osteogenic‐related proteins was higher in the BPPT group than the other groups. Taken together, our results suggest that BPPT promoted early osteointegration, which may provide a novel approach for the clinical treatment of bone defects.
Comprehensive Phenotyping of Extracellular Vesicles in Plasma of Healthy Humans – Insights Into Cellular Origin and Biological Variation
Authors: Holcar Marija , Marić Ivica , Tertel Tobias , Goričar Katja , Čegovnik Primožič Urška , Černe Darko , Giebel Bernd , Lenassi Metka 
Published: January 2025

ABSTRACTDespite immense interest in biomarker applications of extracellular vesicles (EVs) from blood, our understanding of circulating EVs under physiological conditions in healthy humans remains limited. Using imaging and multiplex bead‐based flow cytometry, we comprehensively quantified circulating EVs with respect to their cellular origin in a large cohort of healthy blood donors. We assessed coefficients of variations to characterize their biological variation and explored demographic, clinical, and lifestyle factors contributing to observed variation. Cell‐specific circulating EV subsets show a wide range of concentrations that do not correlate with cell‐of‐origin concentrations in blood, suggesting steady‐state EV subset concentrations are regulated by complex mechanisms, which differ even for EV subsets from the same cell type. Interestingly, tetraspanin+ circulating EVs largely originate from platelets and to a lesser extent from lymphocytes. Principal component analysis (PCA) and association analyses demonstrate high biological inter‐individual variation in circulating EVs across healthy humans, which are only partly explained by the influence of sex, menopausal status, age and smoking on specific circulating EV and/or tetraspanin+ circulating EV subsets. No global influence of the explored subject's factors on circulating EVs was detected. Our findings provide the first comprehensive, quantitative data towards the cell‐origin atlas of plasma EVs, with important implications in the clinical use of EVs as biomarkers.
Selective synthesis of triacylglycerols by the ADS‐17‐supported Candida antarctica lipase B through esterification of oleic acid and glycerol
Authors: Zheng Jiawei , Zhang Qiangyue , Zhong Nanjing 
Published: January 2025

AbstractBACKGROUNDImmobilized enzyme possessing both high activity and good selectivity is important in practice. In this study, Candida antarctica lipase B (CALB) was immobilized onto the macroporous resin ADS‐17 for triacylglycerol (TAG) synthesis through esterification of oleic acid and glycerol. The reaction conditions were optimized by single‐factor study and orthogonal test, and the reusability of the immobilized CALB (CALB@ADS‐17) was evaluated. In addition, the mechanism of lipase immobilization was studied and the catalytic mechanism of CALB@ADS‐17 was investigated.RESULTSOleic acid conversion up to 99.20% and TAG content at 91.58 wt% could be obtained under optimal conditions. In addition, the CALB@ADS‐17 retained 84.28% of its initial activity after 11 cycles of reuse. The mechanism of lipase immobilization was through hydrophobic adsorption. The relationship between temperature and oleic acid conversion was lnV0 = 6.3316 − 4.3321/T, and the activation energy (Ea) was 36.02 kJ mol−1. CALB@ADS‐17 did not exhibit an obvious interfacial activation phenomenon. Its kinetic behavior can be described by the Michaelis–Menten model, whose kinetic parameters of vmax, kcat, Km, Ki, and kcat/Km were 0.01265 μmol L−1 s−1, 9310.72 s−1, 0.4907 mmol L−1, 3.997 mmol L−1, and 1.90 × 104 L mmol−1 s−1, respectively.CONCLUSIONCALB@ADS‐17 showed good esterification performance and exhibited good selectivity towards TAG generation. In addition, CALB@ADS‐17 exhibited good reusability in esterification reactions and has potential in practical applications. © 2025 Society of Chemical Industry.