bluuebunny/crossref_metadata_2025_split huggingface dataset:
Different gastric tubes in esophageal reconstruction during esophagectomy
Authors: Sun Shaowu , Wang Zhulin , Huang Chunyao , Li Kaiyuan , Liu Xu , Fan Wenbo , Zhang Guoqing , Li Xiangnan 
Published: July 2023

AbstractEsophagectomy is currently the mainstay of treatment for resectable esophageal carcinoma. Gastric grafts are the first substitutes in esophageal reconstruction. According to the different tailoring methods applied to the stomach, gastric grafts can be classified as whole stomach, subtotal stomach and gastric tube. Gastric-tube placement has been proven to be the preferred method, with advantages in terms of postoperative complications and long-term survival. In recent years, several novel methods involving special-shaped gastric tubes have been proposed, which have further decreased the incidence of perioperative complications. This article will review the progress and clinical application status of different types of gastric grafts from the perspectives of preparation methods, studies of anatomy and perioperative outcomes, existing problems and future outlook.
Effectiveness of structural walls in improving the serviceability of a seismically-retrofitted RC building
Authors: Şimşek Ahmet , Yurdakul Özgür , Duran Burak , Tunaboyu Onur , Yıldırım Suat , Avşar Özgür 
Published: July 2023

AbstractA moderate earthquake with a magnitude Mw of 6.8 hit the Elazig Province of Turkey on January 24th, 2020, causing fatalities and structural damage/failure. Following the earthquake, a field reconnaissance was conducted at the Administration and Operation Campus of Karakaya Dam, which is 19 km from the earthquake epicenter. The exhibited performances in two side-by-side nominally identical reinforced concrete (RC) buildings with the same material properties and soil conditions differed significantly. The main reason lies in the preventive action taken before the earthquake in one of the buildings. The building retrofitted with additional structural walls had a slight/no damage level. However, the non-retrofitted building suffered severe damage due to large cracks in numerous infill walls, some of which were exposed to partial collapse. That makes the non-retrofitted building unserviceable, requiring evacuation after the earthquake. The field-observed building damage was compared with the seismic performances acquired from their refined numerical models for the recorded ground motions. The photographic documentation exposing the entire performance and damage level in non-retrofitted and retrofitted buildings was quantified by static pushover and nonlinear response history analyses. The post-earthquake performance of nonstructural members in retrofitted and non-retrofitted buildings was simulated with reasonable accuracy.
A Deep Learning based Scalable and Adaptive Feature Extraction Framework for Medical Images
Authors: Loukil Zainab , Mirza Qublai Khan Ali , Sayers Will , Awan Irfan 
Published: July 2023

AbstractFeatures extraction has a fundamental value in enhancing the scalability and adaptability n of medical image processing framework. The outcome of this stage has a tremendous effect on the reliability of the medical application being developed, particularly disease classification and prediction. The challenging side of features extraction frameworks, in relation to medical images, is influenced by the anatomical and morphological structure of the image which requires a powerful extraction system that highlights high- and low- level features. The complementary of both feature types reinforces the medical image content-based retrieval and allows to access visible structures as well as an in-depth understanding of related deep hidden components. Several existing techniques have been used towards extracting high- and low-level features separately, including Deep Learning based approaches. However, the fusion of these features remains a challenging task. Towards tackling the drawback caused by the lack of features combination and enhancing the reliability of features extraction methods, this paper proposes a new hybrid features extraction framework that focuses on the fusion and optimal selection of high- and low-level features. The scalability and reliability of the proposed method is achieved by the automated adjustment of the final optimal features based on real-time scenarios resulting an accurate and efficient medical images disease classification. The proposed framework has been tested on two different datasets to include BraTS and Retinal sets achieving an accuracy rate of 97% and 98.9%, respectively.
Establishment of liquid phase double antibody radioimmunoassay system for in-vitro determination of erythropoietin hormone in human serum
Authors: Ebeid N. H. , El-Shershaby Hanan M. , Shafik H. M. , Moustafa K. A. 
Published: July 2023

AbstractThe aim of study was the production of polyclonal antibody of erythropoietin hormone (Anti-EPO) to determine EPO in human serum by liquid-phase radioimmunoassay (RIA). Production of anti-EPO was performed by immunizing Balb/C mice with EPO antigen using primary immunization and four booster doses. EPO tracer (125I-EPO) was prepared using Chloramine-T method. Additionally, EPO standards were mad. Furthermore, the assay was optimized and validated in additional studies. In conclusion, the elaborated EPO-RIA system exhibits a simple, accurate, specific and sensitive method for determining EPO concentration in human serum and might be suitable for clinical diagnosis of myeloproliferative diseases.
Solving a one-dimensional moving boundary problem based on wave digital principles
Authors: Al Beattie Bakr , Ochs Karlheinz 
Published: July 2023

AbstractWe report on a novel method for solving one-dimensional moving boundary problems based on wave digital principles. Here, we exploit multidimensional wave digital algorithms to derive an efficient and robust algorithm for the solution of the considered problem. Our method lets the wave digital model, on which the algorithm is based, expand according to the size of the solution domain. The expanding model introduces new dynamical elements, which must be properly initialized to obtain a calculable algorithm. To deal with this problem, we make use of linear multistep methods to extrapolate the missing values. Our results show the proposed method to indeed be capable of correctly solving a one-dimensional partial differential equation describing a growing biological axon.
The $$\textrm{CMO}$$-Dirichlet Problem for Elliptic Systems in the Upper Half-Space
Authors: Cao Mingming 
Published: July 2023

AbstractWe prove that for any second-order, homogeneous, $$N \times N$$

N
×
N

elliptic system L with constant complex coefficients in $$\mathbb {R}^n$$

R

n

, the Dirichlet problem in $$\mathbb {R}^n_+$$

R

+
n

with boundary data in $$\textrm{CMO}(\mathbb {R}^{n-1}, \mathbb {C}^N)$$

CMO
(

R

n
-
1

,

C

N

)

is well-posed under the assumption that $$d\mu (x', t) := |\nabla u(x)|^2\, t \, dx' dt$$

d
μ

(

x
′

,
t
)

:
=

|
∇
u

(
x
)

|

2

t

d

x
′

d
t

is a strong vanishing Carleson measure in $$\mathbb {R}^n_+$$

R

+
n

in some sense. This solves an open question posed by Martell et al. [1, Open Question 8], which wishes to formulate and prove a well-posedness result for the Dirichlet problem in $$\mathbb {R}^n_+$$

R

+
n

for L as above, and establish a Fatou-type theorem for null-solutions of L. Our proof relies on a quantitative Fatou-type theorem, which not only guarantees the existence of the pointwise nontangential boundary trace for smooth null-solutions satisfying a strong vanishing Carleson measure condition, but also includes a Poisson integral representation formula of solutions along with a characterization of $$\textrm{CMO}(\mathbb {R}^{n-1}, \mathbb {C}^N)$$

CMO
(

R

n
-
1

,

C

N

)

in terms of the traces of solutions of elliptic systems. Moreover, we are able to establish the well-posedness of the Dirichlet problem in $$\mathbb {R}^n_+$$

R

+
n

for a system L as above in the case when the boundary data belongs to $$\textrm{XMO}(\mathbb {R}^{n-1}, \mathbb {C}^N)$$

XMO
(

R

n
-
1

,

C

N

)

, which lies in between $$\textrm{CMO}(\mathbb {R}^{n-1}, \mathbb {C}^N)$$

CMO
(

R

n
-
1

,

C

N

)

and $$\textrm{VMO}(\mathbb {R}^{n-1}, \mathbb {C}^N)$$

VMO
(

R

n
-
1

,

C

N

)

. Analogously, we formulate a new brand of vanishing Carleson measure conditions and a characterization of $$\textrm{XMO}(\mathbb {R}^{n-1}, \mathbb {C}^N)$$

XMO
(

R

n
-
1

,

C

N

)

in terms of the traces of solutions of elliptic systems.
The impact of public procurement on financial barriers to general and green innovation
Authors: Schäfer Dorothea , Stephan Andreas , Fuhrmeister Sören 
Published: July 2023

AbstractThis study investigates whether public procurement mitigates or exacerbates innovative enterprises’ financial constraints. We distinguish between general and environmentally beneficial innovative enterprises. Theory suggests that the treatment effects of public procurement, particularly when mediated by the demand-pull effect, may lower a company’s funding constraints for innovation. We test this theory with extended probit models allowing for endogenous treatment and selection. The findings reveal a significantly positive treatment effect of public procurement on the probability of facing financial constraints in both areas: general and environmentally beneficial innovative activities. Thus, the principal implications of this study are (1) that being an innovating SME exacerbates financial constraints and (2) that strengthening SMEs’ participation in European public tenders would not contribute to lowering SMEs’ financial constraints. On the contrary, complementary grants or other financial incentives might be necessary to substantially increase the SMEs’ bidding rates in public tenders.
Women’s Endorsement of Heteronormative Dating Scripts is Predicted by Sexism, Feminist Identity, A Preference for Dominant Men, and A Preference Against Short-Term Relationships
Authors: Alba Beatrice , Hammond Matthew D. , Cross Emily J. 
Published: July 2023

AbstractHeteronormative dating scripts involve expectations for women and men to enact different behaviours in romantic contexts with one another, such as men paying on dates and making marriage proposals. While previous research has shown that sexism and feminist identity predicts the endorsement of these scripts, there is a lack of research on other potential predictors relevant to women’s personal preferences for partners and relationships. We examined these novel predictors in three online samples of single women in Australia (N1 = 112,N2 = 157,N3 = 189). Hierarchical regressions and an integrative meta-analysis identified that women’s endorsement of heteronormative dating scripts was predicted by higher benevolent sexism, higher hostile sexism, and lower feminist identity, as well as a greater preference for dominant men as partners and a lower preference for short-term relationships. In addition, path modelling suggested that a greater preference for male partner dominance partially explained the association between women’s benevolent sexism and the endorsement of these scripts. Overall, women’s endorsement of heteronormative dating scripts was more strongly related to their sexist attitudes than their partner or relationship preferences, suggesting that traditional romantic prescriptions are interconnected with gender inequalities, despite the relevance of personal preferences beyond sexism.
Demonstration of new attacks on three healthcare network protocols in a lab environment
Authors: Dupont Guillaume , dos Santos Daniel , Dashevskyi Stanislav , Vijayakumar Sangavi , Murali Sashaank P. , Costante Elisa , den Hartog Jerry , Etalle Sandro 
Published: July 2023

AbstractHealthcare delivery organizations such as hospitals are complex infrastructures comprising a broad range of networked devices. They include connected medical devices which can deliver health care, support hospitals’ operations, and can exchange patients’ data over healthcare network protocols. Previous research has pointed out weaknesses in the implementations of some of these protocols, and demonstrated how they could be abused by malicious actors in hospitals. There are still other healthcare network protocols for which we have limited knowledge, and no security analysis can be found in the literature. This can represent an issue, as these technologies may also have vulnerabilities which could, if exploited, impact hospitals’ operations and patients’ data. For this reason, we investigate in this paper three healthcare protocols found in hospital networks: the POCT1-A and LIS02-A standards used by some point-of-care and laboratory devices, and the proprietary protocol Data Export used by some Philips patient monitors. We explain how to build a test lab to perform security research on medical devices, in which we demonstrate four attacks highlighting how the selected protocols can be abused. This research provides greater knowledge of threats relevant to healthcare delivery organizations, and helps to enhance network security monitoring capabilities such as intrusion detection systems. More specifically, signatures can be created to detect attacks on these protocols and datasets can be assembled to assist the development and testing of hospital-specific intrusion detection systems.
Preparing for the future of work: a novel data-driven approach for the identification of future skills
Authors: Brasse Julia , Förster Maximilian , Hühn Philipp , Klier Julia , Klier Mathias , Moestue Lars 
Published: July 2023

AbstractThe future of work is changing rapidly as result of fast technological developments, decarbonization and social upheavals. Thus, employees need a new skillset to be successful in the future workforce. However, current approaches for the identification of future skills are either based on s small sample of expert opinions or the result of researchers interpreting the results of data-driven approaches and thus not meaningful for the stakeholders. Against this background, we propose a novel process for the identification of future skills incorporating a data-driven approach with expert interviews. This enables identifying future skills that are comprehensive and representative for a whole industry and region as well as meaningful for the stakeholders. We demonstrate the applicability and utility of our process by means of a case study, where we identify 33 future skills for the manufacturing industry in Baden-Wuerttemberg, Germany. Our work contributes to the identification of comprehensive and representative future skills (for whole industries).
Coaching zur beruflichen Orientierung: Du hast die Wahl und suchst deinen Weg
Authors: Kauffeld Simone , Wittner Britta 
Published: July 2023

ZusammenfassungErste Karriereentscheidungen Jugendlicher und junger Erwachsener sind oft von Unsicherheit begleitet: Welche der vielfältigen Möglichkeiten ist die passende? Um aus vielen Studiengängen und Ausbildungsberufen auszuwählen, ist eine gute Exploration der Möglichkeiten wichtig. Gruppencoaching-Formate bieten hier eine wichtige Möglichkeit, um die ersten Karriereentscheidungen im Übergang von Schule ins Berufsleben oder in das Studium sowie auch später in der Studieneingangsphase zu treffen. Dieser Artikel zeigt anschaulich, dass dieses Format die Schüler:innen in ihrer Entscheidung unterstützen kann und sowohl in Präsenz als auch digital funktioniert.
Antares I: a Modular Photobioreactor Suitable for Photosynthesis and Bioenergetics Research
Authors: Rodríguez-Bolaños Mónica , Vargas-Romero Gloria , Jaguer-García Girian , Aguilar-Gonzalez Zhaida I. , Lagos-Romero Verónica , Miranda-Astudillo Héctor V. 
Published: July 2023

AbstractOxygenic photosynthesis is responsible for most of the fixation of atmospheric CO2. The microalgal community can transport atmospheric carbon into biological cycles in which no additional CO2 is created. This represents a resource to confront the actual climate change crisis. These organisms have evolved to adapt to several environments and different spectral distribution of light that may strongly influence their metabolism. Therefore, there is a need for development of photobioreactors specialized in addressing spectral optimization. Here, a multi-scale modular photobioreactor made from standard glass materials, ad hoc light circuits, and easily accessible, small commercial devices is described. The system is suitable to manage the principal culture variables of research in bioenergetics and photosynthesis. Its performance was tested by growing four evolutionary-distant microalgal species with different endosymbiotic scenarios: Chlamydomonasreinhardtii (Archaeplastida, green primary plastid), Polytomella parva (Archaeplastida, colorless plastid), Euglena gracilis (Discoba, green secondary plastid), and Phaeodactylum tricornutum (Stramenophiles, red secondary plastid). Our results show an improvement of biomass production, as compared to the traditional flask system. The modulation of the incident light spectra allowed us to observe a far-red adaptation in Euglenagracilis with a difference on paramylon production, and it also significantly increased the maximal cell density of the diatom species under green light. Together, these confirm that for photobioreactors with artificial light, manipulation of the light spectrum is a critical parameter for controlling the optimal performance, depending on the downstream goals.
Toxicity Evaluation, Oxidative, and Immune Responses of Mercury on Nile Tilapia: Modulatory Role of Dietary Nannochloropsis oculata
Authors: Zahran Eman , Ahmed Fatma , Hassan Zeinab , Ibrahim Iman , Khaled Asmaa A. , Palić Dušan , El Sebaei Mahmoud G. 
Published: July 2023

AbstractThe current study evaluated the potential ameliorative effect of a dietary immune modulator, Nannochloropsis oculata microalga, on the mercuric chloride (HgCl2)-induced toxicity of Nile tilapia. Nile tilapia (45–50 g) were fed a control diet or exposed to ¼ LC50 of HgCl2 (0.3 mg/L) and fed on a medicated feed supplemented with N. oculata (5% and 10% (50 or 100 g/kg dry feed)) for 21 days. Growth and somatic indices, Hg2+ bioaccumulation in muscles, and serum acetylcholinesterase (AChE) activity were investigated. Antioxidant and stress-related gene expression analyses were carried out in gills and intestines. Histopathological examinations of gills and intestines were performed to monitor the traits associated with Hg2+ toxicity or refer to detoxification. Hg2+ toxicity led to significant musculature bioaccumulation, inhibited AChE activity, downregulated genes related to antioxidants and stress, and elicited histopathological changes in the gills and intestine. Supplementation with N. oculata at 10% was able to upregulate the anti-oxidative-related genes while downregulated the stress apoptotic genes in gills and intestines compared to the unexposed group. In addition, minor to no histopathological traits were detected in the gills and intestines of the N. oculata-supplemented diets. Our data showed the benefit of dietary N. oculata in suppressing Hg2+ toxicity, which might support its efficacy as therapeutic/preventive agent to overcome environmental heavy metal pollution in aquatic habitats.
Renal function changes in patients with subclinical hyperthyroidism: a novel postulated mechanism
Authors: Allam Magdy Mohamed , El-Zawawy Hanaa Tarek , El-Zawawy Tarek Hussein 
Published: July 2023

Abstract
Background
Subclinical hyperthyroidism (SCH) is found to be associated with renal dysfunction. Hyperthyroidism is a well-known cause of secondary systolic hypertension. However, the effect of SCH on the kidney and its vasculature is still unknown.

Aim
To assess the presence of renal function changes and renal vasodysfunction in SCH patients and their relation to hypertension.

Methods
The study included 321 patients with SCH and 80 healthy matched controls. Laboratory investigations included thyroid function tests, anti-TSH receptor antibody (TRAb), creatinine, estimated glomerular filtration rate (eGFR), serum osmolarity (S. Osmol), urine osmolarity (U. Osmol), Fractional Excretion of Sodium (FeNa), Fractional Excretion of Potassium (FeK), copeptin (CPP), and aldosterone/renin ratio (ARR). Ultrasound for the thyroid gland, echocardiography, total peripheral resistance (TPR), flow-mediated dilatation (FMD), and Renal Arterial distensibility (RAD) was also done.

Results
Serum creatinine was significantly lower while eGFR was significantly higher in SCH patients compared to euthyroid subjects (mean 0.59 ± 0.11 mg/dl Vs mean 0.8 ± 0.1 mg/dl, p = 0.001 and mean 128.28 ± 14.69 ml/min/1.73m2 Vs mean 100.49 ± 14.9 ml/min/1.73m2, p = 0.013, respectively). The TPR and FMD showed a significant decrease in SCH group compared to controls (mean 975.85 ± 159.33 mmHg.min/L Vs mean 1120.24 ± 135.15 mmHg.min/L, p = 0.045 and mean 7.03 ± 4.02% Vs mean 13.48 ± 4.57%, p = 0.003, respectively). RAD was significantly higher in hypertensive SCH patients compared to normotensive SCH patients (mean 17.82 ± 2.46 mmHg Vs mean 11.98 ± 3.21 mmHg, p = 0.001).

Conclusion
SCH patients showed vascular resistance reduction. Alterations in thyroid hormones and blood pressure could be the driving mechanisms for the change in renal functions in patients with SCH.
Significance of Worst Pattern of Invasion-5 in Early-Stage Oral Cavity Squamous Cell Carcinoma
Authors: Mohamed Shima , Jawad Hadeel , Sullivan Ryan O’ , Callanan Deirdre , Sheahan Patrick , Feeley Linda 
Published: July 2023

Abstract
Background
There is an ongoing need to identify pathologic prognosticators in early-stage oral cavity squamous cell carcinoma (OCSCC) to aid selection of patients who may benefit from adjuvant treatment. The objective of this study was to evaluate the prognostic ability of worst pattern of invasion-5 (WPOI-5) defined by the presence of satellite nodules, extratumoural perineural invasion (PNI) and/or extratumoural lymphovascular space invasion (LVI) in low-stage, node negative OCSCC.

Methods
This was a retrospective study of 160 patients with T1/T2N0 tumours staged using TNM7 treated surgically. Histology of the primary tumour was re-reviewed as appropriate to assess for the presence of WPOI-5 parameters. Univariate and multivariate analysis assessing impact of pathological features on survival outcomes was performed.

Results
On univariate analysis, WPOI-5 and its 3 constituent components of satellite nodules, extratumoural PNI and extratumoural LVI were all significantly associated with disease-specific survival (DSS) and overall survival (OS). On multivariate analysis, satellite nodules (odds ratio 6.61, 95% CI 2.83–15.44, p < 0.0001) and extratumoural LVI (odds ratio 9.97, 95% CI 2.19–45.35, p = 0.003) were independently associated with OS. Postoperative radiotherapy (odds ratio 0.40, 95% CI 0.19–0.87, p = 0.02) and non-tongue subsite (odds ratio 3.03, 95% CI 1.70–5.39, p = 0.0002) were also significantly associated with OS on multivariate analysis.

Conclusion
Satellite nodules and extratumoural LVI correlated significantly with survival outcomes in our early-stage OSCC cohort. Further study is required to investigate the benefit of adjuvant treatment in these cases and to ascertain if WPOI-5 parameters including satellite nodules should be mandatory reporting data elements.