bluuebunny/crossref_metadata_2025_split huggingface dataset:
A novel quasi-zero-stiffness isolation platform via tunable positive and negative stiffness compensation mechanism
Authors: Chai Yuyang , Bian Jing , Li Meng 
Published: March 2023

Abstract
Various quasi-zero stiffness (QZS) systems with high-static and low-dynamic stiffness (HSLDS) have been applied extensively to attenuate low-frequency vibrations. However, in the majority of cases, the negative stiffness unit exhibits nonlinear stiffness behaviors, and the method of realizing QZS is limited to compensate the nonlinear negative stiffness through linear springs. Hence, a novel linkage anti-vibration structure (LAVS) via linear positive and negative stiffness compensation mechanism is proposed and studied for exploring its advantages in low-frequency vibration isolation. The LAVS is composed of a symmetric polygonal structure (SPS) and a vertical spring. The static stiffness behavior is first investigated, revealing the inherent positive and negative stiffness compensation mechanism of linear springs to the SPS. By tuning structural parameters, the linear spring can completely compensate the linear negative stiffness of the SPS to achieve enhanced QZS over a larger stroke. Numerical simulation is carried out to verify the theoretical result and demonstrates the effectiveness of the presented stiffness compensation mechanism. Based on the Lagrange principle, a dynamic equation is established and then solved via the multiple scales method to obtain the displacement transmissibility. The effects of key parameters such as the rod lengths, equilibrium points and damping factors on the amplitude-frequency characteristics and vibration transmissibility are analyzed. Compared with existing typical QZS and X-shaped isolation systems, the presented LAVS exhibits an enhanced QZS zone with a larger load capacity and can realize superb vibration isolation performance with guaranteed stable equilibrium. The proposed linear positive and negative stiffness compensation mechanism presents new insights for passive vibration isolation design in many engineering applications.
Infection by wMel Wolbachia alters female post-mating behaviors and physiology in the dengue vector mosquito Aedes aegypti
Authors: Avila Frank , Osorio Jessica , Villa-Arias Sara , Camargo Carolina , Ramírez-Sánchez Luis , Barrientos Luisa , Bedoya Carolina , Rúa-Uribe Guillermo , Dorus Steve , Alfonso-Parra Catalina 
Published: March 2023

Abstract
Globally invasive Aedes aegypti mosquitoes disseminate numerous arboviruses that impact human health. One promising method to control Ae. aegypti populations is transinfection with the intracellular bacterium Wolbachia pipientis, a symbiont that naturally infects ~40-52% of insects but is normally absent from Ae. aegypti. Transinfection of Ae. aegypti with the wMel Wolbachia strain induces cytoplasmic incompatibility, allowing infected individuals to rapidly invade native populations. Further, wMel Wolbachia-infected females display refractoriness to medically relevant arboviruses. Thus, wMel Wolbachia-infected Ae. aegypti are being released in several areas to replace native populations, thereby suppressing disease transmission by this species. Wolbachia is reported to have minimal effects on Ae. aegypti fertility, but its influence on other reproductive processes is unknown. Female insects undergo several post-mating physiological and behavioral changes required for optimal fertility. Post-mating responses (PMRs) in female insects are typically elicited by receipt of male seminal fluid proteins (SFPs) transferred with sperm during mating, but can be modified by other factors, such as adult age, nutritional status, and microbiome composition. To assess how Wolbachia infection influences Ae. aegypti female PMRs, we collected wMel Wolbachia-infected Ae. aegypti from the field in Medellín, Colombia and introduced the bacterium into our laboratory strain. We found that Wolbachia influences female fecundity, fertility, and re-mating incidence. Further, we observed that Wolbachia significantly extends longevity of virgin females. Changes in female PMRs are not due to defects in sperm transfer by infected males, or sperm storage by infected females. Using proteomic methods to examine the seminal proteome of infected males, we found that Wolbachia infection has a moderate effect on SFP composition. However, we identified 125 Wolbachia proteins that are paternally transferred to females by infected males. Surprisingly, the CI factor proteins (Cifs), were not detected in the ejaculates of Wolbachia-infected males. Our findings indicate that Wolbachia infection of Ae. aegypti alters female post-mating responses, potentially influencing control programs that utilize Wolbachia-infected individuals.
IKKε inhibition by amlexanox ameliorates high glucose-mediated endothelial senescence via the NF-κB/iNOS and AKT/eNOS signaling pathways
Authors: Wang Xianghong , He Qian , Zou Xiulan , Yao Kecheng 
Published: March 2023

Abstract
High glucose (HG)-induced endothelial cell senescence can induce atherosclerosis and is closely related to the vascular complications of diabetes. Amlexanox (AM), a selective IKKε inhibitor, can protect against metabolic diseases. This study examined how amlexanox inhibits endothelial senescence under high glucose conditions and explores its mechanisms of action .. HUVECs were incubated with HG (33 mmol/L), and then IKKε was targeted with shRNA lentivirus transfection or treatment with amlexanox. Cellular senescence indicators were examined by SA-β-gal staining, reactive oxygen species (ROS) measurement with dihydroethidium, and determining intracellular and serum levels of nitric oxide (NO). The levels of proteins related to the NF-κB/iNOS and AKT/eNOS pathways were assessed through Western blot analysis.. In this study, we found that high glucose promoted cell senescence, significantly increased ROS levels and decreased NO formation, and these effects were prevented by IKKε silencing and amlexanox treatment. In addition, high glucose decreased the phosphorylation of AKT/eNOS and increased the phosphorylation of NF-κB/iNOS in HUVECs, resulting in an imbalance in the p-eNOS/p-iNOS ratio. These trends were reversed by IKKε inhibition. Thus, amlexanox can target IKKε to alleviate HG-induced endothelial senescence by normalizing the NF-κB/iNOS and AKT/eNOS signaling pathways.
Inactive long prokaryotic Argonaute systems employ various effectors to confer immunity via abortive infection
Authors: Song Xinmi , Lei Sheng , Liu Shunhang , Liu Yanqiu , Fu Pan , Zeng Zhifeng , Yang Ke , Chen Yu , Li Ming , She Qunxin , Han Wenyuan 
Published: March 2023

Abstract
Argonaute proteins (Agos) bind short nucleic acids as guides and are directed by them to recognize target complementary nucleic acids. Prokaryotic Agos (pAgos) are extremely diverse, with potential functions in microbial defense. The functions and mechanisms of a group of full-length yet inactive pAgos, long-B pAgos, remain enigmatic. Here, we show that most long-B pAgos constitute cell suicide systems together with their various associated proteins, including nucleases, Sir2-domain-containing proteins and trans-membrane proteins, respectively. Among them, the long-B pAgo-nuclease system utilizes an RNA-programmed and target-recognition-activated collateral DNA cleavage activity to sense invaders and mediate genomic DNA degradation. This kills the infected cells and results in depletion of the invader from the cell population. The data indicate that the long-B pAgo systems induce cell death with various effector proteins after recognition of invading nucleic acids, corresponding to an immune response via abortive infection.
ezSingleCell: An integrated one-stop single-cell and spatial omics analysis platform for bench scientists
Authors: Chen Jinmiao , Sethi Raman , Ang Kok Siong , Li Mengwei , Long Yahui , Ling Jingjing 
Published: March 2023

Abstract

ezSingleCell is an interactive and easy-to-use application for the analysis and integration of multiple single-cell and spatial omics data types. It integrates the best-performing publicly available methods and in-house novel algorithms for in-depth data analysis, integration, and interactive data visualization. By integrating the relevant tools to form a complete analysis pipeline, we save users from the hassles of choosing among the enormous diversity of available methods, installing individual packages, and reformatting the data for different analysis steps. ezSingleCell takes input data in a variety of formats such as text files or Cell Ranger/ Space Ranger output and produces publication ready figures and tables. Users can customize the relevant parameters to ensure the quality and accuracy of their data analysis. Users can also download and store the R objects from ezSingleCell to perform additional offline analyses. ezSingleCell’s streamlined interface can analyze a standard scRNA-seq dataset containing 3000 cells in less than five mins. ezSingleCell is also accompanied by an in-depth manual and video tutorials to guide users. Overall, these features make ezSingleCell a convenient and easy web service for single cell and spatial analysis without requiring prior programming knowledge. ezSingleCell is available in two forms: an installation-free web application (https://immunesinglecell.org/ezsc/) or a software package with a shinyApp interface (https://github.com/JinmiaoChenLab/ezSingleCell2) that runs on a personal computer with a low memory requirement of 8 Gb RAM.
A case of robot-assisted radical nephroureterectomy (RANU) in a patient with horseshoe kidney
Authors: Shiode Ryo , Watanabe Ryuta , Toshio Kakuda , Suzuki Daiichiro , Nobumori Shota , Sugihara Naoya , Yamakawa Maki , Saiki Kaori , Kono Reina , Noda Terutaka , Nishimura Kenichi , Fukumoto Tetsuya , Miura Noriyoshi , Miyauchi Yuki , Kikugawa Tadahiko , Saika Takashi 
Published: March 2023

Abstract
Background:
Renal pelvic carcinoma occurring in a horseshoe kidney is rare. Further, there are few reports on robotic surgery in horseshoe kidneys. We report the case of a patient who underwent a robotic nephroureterectomy for right renal pelvic carcinoma in a horseshoe kidney.
Case presentation:
A 64-year-old male patient was diagnosed with right renal pelvic carcinoma (cT1N0M0) in a horseshoe kidney. Robot-assisted radical nephroureterectomy was performed using the da Vinci Xi® surgical system with imaging of the anatomical structures using 3D constructed imaging software (SYNAPSE VINCENT®). The isthmus was dissected using monopolar curved scissors, and the edge was coagulated using ball electrodes. The operating time was 6 h 31 min, and console time was 5 h 2 min. Blood loss was 185 mL. The surgery was performed without complications, and the patient was discharged after 8 days. The pathological diagnosis was invasive urothelial carcinoma (pT3, high-grade carcinoma with CIS) with a negative surgical margin.
Conclusion:
Robotic surgical procedures are safe in radical nephroureterectomy in a horseshoe kidney, and preoperative 3D construction images provide anatomical perception.
Extracorporeal Shockwave Therapy is an Effective Adjunctive Treatment for Late-Stage Breast Cancer-Related Lymphedema when Complex Decongestive Therapy is Not Enough
Authors: Wu Mu-Hsun , Huang Hung-Ya , Huang Ming-Hsuan , Hoe Zheng-Yu 
Published: March 2023

Abstract
Purpose:
Complex decongestive treatment (CDT) and extracorporeal shockwave therapy (ESWT) have been shown to be effective in the treatment of early-stage breast-cancer-related lymphedema (BCRL) but less so for later-stage. This study examined the effects of ESWT on late-stage BCRL (Stages IIb and III) as an adjunct treatment after prolonged CDT failed.
Patients and Methods:
11 female patients with BCRL who had undergone at least 6 months of CDT monotherapy without measurable effects received ESWT 3 times a week for 12 weeks with concurrent CDT. Limb circumference and the thicknesses of the skin, subcutaneous tissue, and muscle layers were measured using a measuring tape and ultrasound, respectively, in the most edematous regions of both the forearm and upper arm.
Results:
After the addition of ESWT to CDT, the mean circumference, thickness of the skin layer, and the thickness of the subcutaneous tissue layer of the affected limb decreased significantly (p < 0.05), while the mean thickness of muscle on the affected limb increased slightly but not significantly (forearm, p = 0.348; upper arm, p = 0.100). On the unaffected limb, no significant changes were measured (p > 0.05).
Conclusions:
ESWT as an adjunct treatment to CDT monotherapy after a period of 6 months showed significant reductions in distal and proximal upper limb circumference, skin layer thickness, and subcutaneous tissue layer thickness in patients suffering from prolonged late stage (IIb and III) BCRL, suggesting that the combination therapy was effective on severe BCRL and fibrotic lesions that could not be effectively treated by CDT alone.
Best Practice Guidance for Antibiotic Audit and Feedback interventions in Primary Care: a modified Delphi study from the Joint Programming Initiative on Antimicrobial Resistance - Primary Care Antibiotic Audit and Feedback Network (JPIAMR-PAAN)
Authors: Schwartz Kevin L. , Xu Alice X.T. , Alderson Sarah , Bjerrum Lars , Brehaut Jamie , Brown Benjamin C. , Bucher Heiner C. , De Sutter An , Francis Nick , Grimshaw Jeremy , Gunnarsson Ronny , Hoye Sigurd , Ivers Noah , Lecky Donna M. , Lindbaek Morten , Linder Jeffrey A. , Little Paul , Michalsen Benedikte Olsen , O’Connor Denise , Pulcini Celine , Sundvall Par-Daniel , Lundgren Pia Touboul , Verbakel Jan Y. , Verheij Theo J. 
Published: March 2023

Abstract

Background: Primary care is a critical partner for antimicrobial stewardship efforts given its high human antibiotic usage. Peer comparison audit and feedback (A&F) is often used to reduce inappropriate antibiotic prescribing. The design and implementation of A&F may impact its effectiveness. There are no best practice guidelines for peer comparison A&F in antibiotic prescribing in primary care.
Objective: To develop best practice guidelines for peer comparison A&F for antibiotic prescribing in primary care in high income countries by leveraging international expertise via the Joint Programming Initiative on Antimicrobial Resistance – Primary Care Antibiotic Audit and Feedback Network (JPIAMR-PAAN).
Methods: We used a modified Delphi process to achieve convergence of expert opinions on best practice statements for peer comparison A&F based on existing evidence and theory. Three rounds were performed, each with online surveys and virtual meetings to enable discussion and rating of each best practice statement. A five-point Likert scale was used to rate consensus with a median threshold score of 4 to indicate a consensus statement.
Results: The final set of guidelines include 13 best practice statements in four categories: general considerations (n=3), selecting feedback recipients (n=1), data and indicator selection (n=4), and feedback delivery (n=5).
Conclusion: We report an expert-derived best practice recommendations for designing and evaluating peer comparison A&F for antibiotic prescribing in primary care. These 13 statements can be used by A&F designers to optimize the impact of their quality improvement interventions, and improve antibiotic prescribing in primary care.
Dynamical Friction of Pulsars in Globular Clusters
Authors: Xie Yi 
Published: March 2023

Abstract
Pulsars are supposed to be powerful probes for the internal dynamics of the Galactic globular clusters (GCs). During the motion in the clusters, the pul-sars experience a drag force through dynamical friction (DF). We show that the effects of DF on the acceleration as well as the related timing parameters are significant for millisecond pulsars in the inner regions of core-collapsed clusters with high core densities. We also consider the influence of the IMBH that may exist in the center of a GC on the drag force, and found that it can improve dramatically the acceleration within its influenced region. The timing effects of the drag force may be used to increasing the accuracy of timing parameters, and may provide a unique tool to study the role of DF in GC dynamics.
Special-District Proliferation and Local Financial Condition: The Hidden Cost of the Externalized Service Responsibility
Authors: Park HyungGun 
Published: March 2023

Abstract
General-purpose governments have increasingly relied on creating special districts to provide specialized public services to subsections of their jurisdictions. There are many presumed advantages of pursuing this strategy, including displacing some of the own-source tax burden associated with providing such services with outside revenue sources. This goal is feasible, as special districts are usually formed across overlapping tax bases across multiple jurisdictions. However, this empirical analysis of 51,000 special district governments in the U.S., collected over the past four decades, finds that increased special district proliferation has generally resulted in decreased financial conditions of general-purpose governments. These empirical results demonstrate that claim public goods provision through special districts produces indirect financial stress on general-purpose governments that must then struggle to use less efficient methods for providing the same or similar services to their under-served citizens who are not covered by the special district.
Fiscal performance of West Bengal as a General Category States in India : Is it dynamics ?
Authors: Sardar Satchidananda Sardar Satchidananda 
Published: March 2023

Abstract
This study has tried to explore the fiscal performance of West Bengal and compare it with that of other general states in India. It is very important to be aware of the fiscal performance of a country or state. In 2003, India established the Fiscal Responsibility and Budget Management Act (FRBMA), a fiscal framework with principles to promote long-term macroeconomic stability. Achieving intergenerational justice in fiscal management is critical. All of these programs and laws attempt to boost revenue, lower the deficit, and ensure fiscal sustainability at the federal and state levels for both macroeconomic and microeconomic stability. In this paper, three indicators have been used for the calculation of fiscal performance: the Indicator of Deficit Index (IDI), the Own Revenue Effort Index (OREI) and the Debt and Expenditure Index (EDSI). The fiscal performance of West Bengal among the 17[1]general category states is not satisfactory; rather, it occupies the worst position among states and the performance did not improve over the period of time . Basically, this is due to low tax collection by the state and a higher amount of expenditure. Since the performance did not change significantly hence the fiscal performance of West Bengal is not dynamic.
[1] Although there are 18 general category states in India, I have considered 17 general category states because Telegana state was formed in 2013 . My study paper has tried to explore the fiscal performance of West Bengal from 2003–2004 to 2020–2021.
Compact Stars in κ(R, T) Gravity
Authors: Taşer Doğukan , Doğru Serta¸c Serkan 
Published: March 2023

Abstract
The study is to organized for investigation of a new solution for stellarobjects in κ(R, T ) theory. We investigate whether Krori-Barua modelproduces valid results in κ(R, T ) theory. We attain field equationsthrough Krori-Barua metric form related with geometry of inner space.From field equations, we obtain all unknown matter components κ(T ) =8πG−λT case in the theory. Constructed model is considered with someclass of compact stars such as 4U1820 − 30, SAXJ1808.4 − 3658and HerX − 1. To prove physical stability of constructed model, weinvestigate both normal and effective matter form behaviors by way ofsome physical conditions. It is found that all conditions are valid foreffective matter. Therefore, this study reveals consistency of both thecompact star model and the gravitation theory. But remarkable point isthat normal matter has to face with some problem in the κ(R, T ) theory.
A novel risk prediction nomogram for early death in patients with resected synchronous multiple primary colorectal cancer based on the SEER database
Authors: Zhang Xiangyu , Zhao Liang , Hu Yanpeng , Deng Kai , Ren Wanbo 
Published: March 2023

Abstract
Background:
Synchronous multiple primary colorectal cancer (SMPCC) involves the simultaneous occurrence of 2 or more independent primary malignant tumors in the colon or rectum. Although SMPCC is rare, it results in a higher incidence of postoperative complications and mortality compared to patients with single primary colorectal cancer (SPCRC).
Methods:
The clinical factors and survival outcomes of SMPCC patients registered on the Surveillance, Epidemiology, and End Results (SEER) database between 2000 and 2017 were extracted. The patients were divided into the training and validation cohorts using a ratio of 7:3. Univariate and multivariate logistic regression analyses were used to identify the independent risk factors for early death. The performance of the nomogram was evaluated using the concordance index (C-index), calibration curves, and the area under the curve (AUC) of a receiver operating characteristics curve (ROC). A decision curve analysis (DCA) was used to evaluate the clinical utility of the model in relation to the standard TNM system.
Results:
A total of 4386 SMPCC patients were enrolled in the study and randomly assigned to the training (n = 3070) and validation (n = 1316) cohorts. The multivariate logistic analysis identified age, chemotherapy, radiotherapy, T stage, N stage, and M stage as independent risk factors for all-cause and cancer-specific early death. The marital status was associated with all-cause early death, and the tumor grade was associated with cancer-specific early death. In the training cohort, the nomogram achieved a C-index of 0.808 (95% CI, 0.784-0.832) and 0.843 (95% CI, 0.816-0.870) for all-cause and cancer-specific early death, respectively. Following validation, the C-index was 0.797 (95% CI, 0.758-0.837) for all-cause early death and 0.832 (95% CI, 0.789-0.875) for cancer-specific early death. The ROC and calibration curves indicated that the model had good stability and reliability. The DCA showed that the nomogram had a better clinical net value than the TNM staging system.
Conclusion:
Our nomogram can provide a simple and accurate tool for clinicians to predict the risk of early death in SMPCC patients undergoing surgery and could be used to optimize the treatment according to the patient's needs.