bluuebunny/crossref_metadata_2025_split huggingface dataset:
Urban tourism destination image: a bibliometric visualization review
Authors: Guo Xin 
Published: August 2023

PurposeThis paper aims to systematically visualize the structure and trends from 2005 to 2021, which will help scholars gain a deeper appreciation for existing studies and grasp future research possibilities and directions.Design/methodology/approachThe approach is bibliometric, using VOSviewer and CiteSpace to analyze 765 journal articles and reviews from the Web of Science (WoS) and Scopus databases over the past 16 years.FindingsThere is considerable interest in urban tourism destination image (U-TDI), partly because of the role of image in promoting the economic development of urban tourism and the associated benefits to stakeholders. Most research output concerns China, the USA, Spain and the United Kingdom (UK); research in the USA context has had a particularly wide range of influence. Highly cited journals play a crucial role, while subject structure, key articles and high-frequency keywords indicate popular topics, sub-themes and development trends. Drawing on these findings, the authors identify four topics that deserve further study.Originality/valueThis systematic review will enhance understanding of U-TDI research and inform future research directions as well as highlighting the need to explore destination image in greater depth, it guides policymakers in the tourism industry seeking to develop city image.
The relationship between the ecologisation of farms and total factor productivity: A continuous treatment analysis
Authors: Baráth Lajos , Fertő Imre 
Published: July 2023

AbstractThe European Green Deal aims to mitigate the environmental impact of food production while improving the income of primary producers and strengthening the EU's competitiveness. We examine how the degree of ecologisation affects farms' total factor productivity (TFP). Our analysis combines a random‐parameter stochastic production frontier model with a composite indicator and a dose–response function approach. Results show a monotonically decreasing relationship between ecologisation and expected TFP level. On average, a one‐step increase in the degree of ecologisation results in a 12% decrease in TFP. However, the results indicate a non‐linear relationship. Three regions of the dose–response function can be distinguished; associated with high, medium and low degrees of ecologisation. In a region with a low degree of ecologisation, farms can increase the degree of ecologisation without reducing TFP. Both efficiency and technological differences contribute to these differences, but the main reason is technological. With increasing ecologisation, farm technology becomes more ‘land using’. Therefore, farms can increase their TFP and degree of ecologisation simultaneously by using land‐saving technologies or through sustainable intensification.
Perspectives on contingency management for alcohol use and alcohol‐associated conditions among people in care with HIV
Authors: Cohen Shawn M. , DePhilippis Dominick , Deng Yanhong , Dziura James , Ferguson Tekeda , Fucito Lisa M. , Justice Amy C. , Maisto Stephen , Marconi Vincent C. , Molina Patricia , Paris Manuel , Rodriguez‐Barradas Maria C. , Simberkoff Michael , Petry Nancy M. , Fiellin David A. , Edelman E. Jennifer 
Published: August 2023

AbstractBackgroundContingency management (CM) is an evidence‐based approach for reducing alcohol use; however, its implementation into routine HIV primary care‐based settings has been limited. We evaluated perspectives on implementing CM to address unhealthy alcohol use and associated conditions for people with HIV in primary care settings.MethodsFrom May 2021 to August 2021, we conducted two focus groups with staff involved in delivering the intervention (n = 5 Social Workers andn = 4 Research Coordinators) and individual interviews (n = 13) with a subset of participants involved in the multi‐siteFinancial Incentives, Randomization, and Stepped Treatment (FIRST)trial. Qualitative data collection and analyses were informed by thePromoting Action on Research Implementation in Health Service (PARIHS)implementation science framework, includingevidence(perception of CM),context(HIV primary care clinic and CM procedures), andfacilitation(feasibility outside the research setting).ResultsSeveral major themes were identified. Regarding theevidence, participants lacked prior experience with CM, but the intervention was well received and, by some, perceived to lead to lasting behavior change. Regarding the clinicalcontextfor the reward schedule, the use of biochemical testing, specifically fingerstick phosphatidylethanol testing, and the reward process were perceived to be engaging and gratifying for both staff and patients. Participants indicated that the intervention was enhanced by its co‐location within the HIV clinic. Regardingfacilitation, participants suggested addressing the intervention's feasibility for non‐research use, simplifying the reward structure, and rewarding non‐abstinence in alcohol use.ConclusionsAmong patients and staff involved in a clinical trial, CM was viewed as a helpful, positive, and feasible approach to addressing unhealthy alcohol use and related conditions. To enhance implementation, future efforts may consider simplified approaches to the reward structure and expanding rewards to non‐abstinent reductions in alcohol consumption.
Star CEOs and ESG performance in China: An integrated view of role identity and role constraints logics
Authors: Li Mengyao , Huang Min , Wang Dong , Li Xiaobo 
Published: July 2023

AbstractThis study seeks to shed light on the effect of star CEOs on the environmental, social, and governance (ESG) performance of Chinese firms. Relying on the theoretical perspective of role identity and role constraints, we analyze data from 1222 Chinese firms listed on the Shanghai and Shenzhen Stock Exchanges from 2006 to 2019. The results analyzed using the ordinary least squares estimate method reveal a positive effect of star CEOs' extreme confidence and legitimacy pressure mechanisms on ESG performance. We also find that this positive relationship is negatively moderated by higher organizational slack but strengthened by a lower level of regional marketization, as the degree of firms' dependence on external stakeholders' resources differs significantly. Additionally, this study finds that ESG activities are less likely to be associated with firm performance if star CEOs pursue them to satisfy their need for star status. These findings supplement the early tests of the influence mechanism of star CEOs on organization‐level results and expand the context discussion of role identity and role constraints theory in the Chinese institutional environment.
Three‐dimensional morphological analysis of the human spleen and its surrounding organs during the early fetal period
Authors: Utsunomiya Natsuko , Nakano Shiori , Katsube Motoki , Yamada Shigehito 
Published: August 2023

AbstractThe spleen has variations in its morphology and is considered to acquire a defined shape in the third month of gestation. However, few studies have investigated spleen development during the first 3 months of fetal life. This study aimed to determine the three‐dimensional (3D) morphogenesis of the spleen during the third month of gestation. In this study, 30 fetal specimens (crown–rump length [CRL]: 22–103 mm) were subjected to magnetic resonance imaging analysis. We manually segmented the spleen, stomach, and adrenal gland, reconstructed 3D models, and analyzed the volume and shape of these organs. The results showed that the variation in spleen size was large compared to that in other organs. Spleen morphology was classified into six types based on the number of splenic surfaces as follows: two‐faced, three‐faced, four‐faced, five‐faced, ovoid, and irregular. Two‐faced spleens were only observed in small specimens, whereas three‐ and four‐faced spleens were observed in larger specimens. We also revealed that the number of fetal splenic surfaces increased as CRL enlarged. Additionally, 3D models indicated that some specimens formed their splenic surfaces without contact with the adjacent organs. This suggested that the splenic surface may be caused not only by pressure from the faced organs but also by an intrinsic program. This study may provide a better understanding of the normal development of the spleen during the early fetal period, and may potentially assist future studies in investigating congenital morphological anomalies of the spleen.
Relevance of National Institutes of Health Stroke Scale subitems for best revascularization therapy in minor stroke patients with large vessel occlusion: An observational multicentric study
Authors: Palazzo Paola , Padlina Giovanna , Dobrocky Tomas , Strambo Davide , Seners Pierre , Mechtouff Laura , Turc Guillaume , Rosso Charlotte , Almiri William , Antonenko Kateryna , Laksiri Nadia , Sibon Igor , Detante Olivier , Mordasini Pasquale , Michel Patrik , Heldner Mirjam R. ,   MINOR STROKE Collaborators
Published: July 2023

AbstractBackground and purposeThe best management of acute ischemic stroke patients with a minor stroke and large vessel occlusion is still uncertain. Specific clinical and radiological data may help to select patients who would benefit from endovascular therapy (EVT). We aimed to evaluate the relevance of National Institutes of Health Stroke Scale (NIHSS) subitems for predicting the potential benefit of providing EVT after intravenous thrombolysis (IVT; “bridging treatment”) versus IVT alone.MethodsWe extracted demographic, clinical, risk factor, radiological, revascularization and outcome data of consecutive patients with M1 or proximal M2 middle cerebral artery occlusion and admission NIHSS scores of 0–5 points, treated with IVT ± EVT between May 2005 and March 2021, from nine prospectively constructed stroke registries at seven French and two Swiss comprehensive stroke centers. Adjusted interaction analyses were performed between admission NIHSS subitems and revascularization modality for two primary outcomes at 3 months: non‐excellent functional outcome (modified Rankin Scale score 2–6) and difference in NIHSS score between 3 months and admission.ResultsOf the 533 patients included (median age 68.2 years, 46% women, median admission NIHSS score 3), 136 (25.5%) initially received bridging therapy and 397 (74.5%) received IVT alone. Adjusted interaction analysis revealed that only facial palsy on admission was more frequently associated with excellent outcome in patients treated by IVT alone versus bridging therapy (odds ratio 0.47, 95% confidence interval 0.24–0.91; p = 0.013). Regarding NIHSS difference at 3 months, no single NIHSS subitem interacted with type of revascularization.ConclusionsThis retrospective multicenter analysis found that NIHSS subitems at admission had little value in predicting patients who might benefit from bridging therapy as opposed to IVT alone. Further research is needed to identify better markers for selecting EVT responders with minor strokes.
Analysis of hepatocellular carcinoma associated with hepatitis B virus
Authors: Zheng Litao 
Published: July 2023

AbstractThe hepatitis B virus (HBV) is considered one of the main driving forces in the development of hepatocellular carcinoma (HCC). Human HBV is a partially double‐stranded DNA (dsDNA) virus consisting of approximately 3.2 kbp. HBV predominantly infects hepatocytes via the receptor sodium taurocholate cotransporting polypeptide (NTCP) and coreceptor hepatic proteoglycan. The replication of HBV in hepatocytes leads to apoptosis while simultaneously leading to cirrhosis and cancer. Although the integration of dsDNA into the hepatocyte genome seems to be the main cause of mutation, since the discovery of their function, viral proteins have been shown to regulate the P53 pathway or P13K/AKT pathway to prevent host cell apoptosis, causing uncontrolled proliferation of liver cells leading to the formation of solid tumours. The most common treatments involve nucleo(s)tide analogue (NA) and polyethylene glycol (PEG)ylated interferon‐alpha (PegIFN‐α). NA treatment has been found to be effective for the majority of patients and induces few side effects. Nevertheless, the rate of seroconversion is relatively low. PegIFN treatment is contraindicated during pregnancy and leads to a higher morbidity rate, but the seroconversion rate is high. Since medicines and vaccines have been developed, the incidence and mortality of HBV related to HCC have profoundly decreased compared to those in 2000. This review investigates what can be the potential mechanism that HBV can cause HBV and the treatment used in chronic and acute infection.
Histological characteristics of exercise‐induced skeletal muscle remodelling
Authors: Su Qihang , Li Jie , Huang Jingbiao , Cai Qiuchen , Xue Chao , Huang Chenglong , Chen Liyang , Li Jun , Li Dandan , Ge Hengan , Cheng Biao 
Published: July 2023

AbstractThis study aims to analyse the pathological features of skeletal muscle injury repair by using rats to model responses to different exercise intensities. Eighty‐four rats were randomly divided into five groups for treadmill exercise. The short‐term control, low‐intensity, medium‐intensity and high‐intensity groups underwent gastrocnemius muscle sampling after 6, 8 and 12 weeks of exercise. The long‐term high‐intensity group underwent optical coherence tomography angiography and sampling after 18 weeks of exercise. RNA sequencing was performed on the muscle samples, followed by the corresponding histological staining. Differentially expressed genes were generally elevated at 6 weeks in the early exercise stage, followed by a decreasing trend. Meanwhile, the study demonstrated a negative correlation between time and the gene modules involved in vascular regulation. The modules associated with muscle remodelling were positively correlated with exercise intensity. Although the expression of many genes associated with common angiogenesis was downregulated at 8, 12 and 18 weeks, we found that muscle tissue microvessels were still increased, which may be closely associated with elevated sFRP2 and YAP1. During muscle injury‐remodelling, angiogenesis is characterized by significant exercise time and exercise intensity dependence. We find significant differences in the spatial distribution of angiogenesis during muscle injury‐remodelling, which be helpful for the future achievement of spatially targeted treatments for exercise‐induced muscle injuries.
Silencing of the MEG3 gene promoted anti‐cancer activity and drug sensitivity in glioma
Authors: Degirmenci Zehra , Unver Sena , Kilic Turker , Avsar Timucin 
Published: August 2023

AbstractAberrant expression of MEG3 has been shown in various cancers. The purpose of this study is to evaluate the effect of MEG3 on glioma cells and the use of potential chemotherapeutics in glioma by modulating MEG3 expression. Cell viability, migration and chemosensitivity were assayed. Cell death was evaluated in MEG3 overexpressing and MEG3 suppressed cells. MEG3 expression was compared in patient‐derived glioma cells concerning IDH1 mutation and WHO grades. Silencing of MEG3 inhibited cell proliferation and reduced cell migration while overexpression of MEG3 promoted proliferation in glioma cells. MEG3 inhibition improved the chemosensitivity of glioma cells to 5‐fluorouracil (5FU) but not to navitoclax. On the other hand, there is no significant effect of MEG3 expression on temozolamide (TMZ) treatment which is a standard chemotherapeutic agent in glioma. Suppression of the MEG3 gene in patient‐derived oligodendroglioma cells also showed the same effect whereas glioblastoma cell proliferation and chemosensitivity were not affected by MEG3 inhibition. Further, as a possible cell death mechanism of action apoptosis was investigated. Although MEG3 is a widely known tumour suppressor gene and its loss is associated with several cancer types, here we reported that MEG3 inhibition can be used for improving the efficiency of known chemotherapeutic drug sensitivity. We propose that the level of MEG3 should be evaluated in the treatment of different glioma subtypes that are resistant to effective drugs to increase the potential effective drug applications.
Associations of polyneuropathy with risk of all‐cause and cardiovascular mortality, cardiovascular disease events stratified by diabetes status
Authors: Kim Kyuho , Lee Su‐Nam , Ahn Yu‐Bae , Ko Seung‐Hyun , Yun Jae‐Seung 
Published: July 2023

AbstractAims/IntroductionWe investigated the association of polyneuropathy (PN) with all‐cause and cardiovascular (CV) mortality and with cardiovascular disease (CVD) events stratified by diabetes status.Materials and MethodsThis prospective cohort study used the UK Biobank. Polyneuropathy was defined based on nurse‐led interviews or ICD codes for polyneuropathy. Cox proportional hazards models were used to investigate the association of polyneuropathy with clinical outcomes.ResultsA total of 459,127 participants were included in the analysis. Polyneuropathy was significantly associated with all‐cause and cardiovascular mortality, and with CVD events even after adjusting for CVD risk factors across all diabetes statuses. Metabolic parameters HbA1c, waist circumference, BMI and the inflammatory parameter C‐reactive protein showed significant mediation effects for the association between polyneuropathy and CVD. Adherence to a favorable lifestyle was associated with a lower risk of all‐cause and cardiovascular mortality regardless of polyneuropathy status.ConclusionsPolyneuropathy was associated with all‐cause and cardiovascular mortality, and with CVD events in subjects with diabetes or prediabetes, even those having normal glucose tolerance. This study suggests the importance of polyneuropathy as a risk factor for death and highlights the necessity of early diagnosis and lifestyle intervention for those with type 2 diabetes and polyneuropathy.
Housing relocation does not have to induce a significant stress response in captive Japanese macaques (Macaca fuscata)
Authors: Broche Nelson , Gris Vanessa , Suda‐Hashimoto Naoko , Mouri Keiko , Miyabe‐Nishiwaki Takako , Suzuki Juri , Huffman Michael A. 
Published: August 2023

AbstractBackgroundPrevious studies suggest that housing relocation may be stressful for captive non‐human primates. Our study investigated the stress levels of Japanese macaques during a housing relocation by measuring their daily fecal cortisol metabolites, which are often used as an indicator of stress.MethodsTen adult Japanese macaques, single‐housed for research purposes, were relocated to a new facility. Fecal samples were collected daily for 7 days. Cortisol metabolite concentrations were determined via enzyme immunoassay.ResultsNo significant differences in cortisol metabolite levels were found in 7 days, but concentration levels showed that the highest median was associated to the relocation day.ConclusionsThe minimal cortisol metabolite increase suggests that there was a slight activity increase in the hypothalamic‐pituitary‐adrenal axis. Techniques encouraging cooperation of the monkeys, the short time duration of the relocation, and consistency in the environment may have contributed to the minimal stress levels observed.
Preventive dental care utilization and dental caries for Medicaid‐enrolled adolescents in Oregon
Authors: Imani Kimia , Mancl Lloyd A. , Hill Courtney M. , Chi Donald L. 
Published: August 2023

AbstractObjectivesThis study aimed to evaluate the relationship between preventive dental care utilization and untreated dental caries for Medicaid‐enrolled adolescents and to determine if the relationship is moderated by chronic conditions (CC).MethodsThis analysis was based on 2015–2016 Medicaid claims files and survey data collected from adolescents ages 12–18 years enrolled in Oregon Medicaid, who received a dental screening between December 2015 and December 2016 (n = 240). To assess the relationship between preventive dental care utilization and untreated dental caries (defined as decayed tooth surfaces), prevalence ratios (PR) and 95% confidence intervals (CI) were generated using log‐linear regression models. We also tested for an interaction between preventive dental care utilization and CC.ResultsAbout 60.4% of adolescents utilized preventive dental care, 21.7% had CC, and 29.6% had ≥1 decayed tooth surfaces. There were no significant differences in untreated dental caries between adolescents who did and did not utilize preventive dental care (PR: 0.73, 95% CI: 0.33–1.60; p = 0.43). There was not a significant interaction between preventive dental care utilization and CC (p = 0.65). Preventive dental care utilization was not significantly associated with untreated dental caries for adolescents with CC (PR: 0.51, 95% CI: 0.10–2.65; p = 0.42) nor among adolescents without CC (PR: 0.79, 95% CI: 0.33–1.91; p = 0.61).ConclusionsPreventive dental care was not shown to be associated with lower untreated dental caries for Medicaid‐enrolled adolescents or those with CC. Future work that is adequately powered should continue to elucidate this relationship in Medicaid enrollees.
Assessing global trends in Mars magma compositions using ground truth
Authors: McSween Harry Y. , Head James W. , Rogers A. Deanne , Schmidt Mariek E. 
Published: July 2023

AbstractGlobal magmatic trends inferred from gamma‐ray, visible/near‐infrared, and thermal infrared spectrometers on Mars‐orbiting spacecraft have been used to constrain planetary petrogenetic processes and global thermal evolution models. Inferred magmatic trends include temporal variations in the relative proportions of low‐Ca and high‐Ca pyroxenes, and in the abundances of potassium (and total alkalis), silica, FeO* (total iron expressed as FeO), and thorium. These patterns are evaluated for consistency with the compositions of surface igneous rocks of different ages analyzed by Mars rovers and of martian meteorites. Trends of decreasing low‐Ca pyroxene/total pyroxene ratios and of decreasing potassium (and total alkalis), with time are generally supported by surface rock analyses. However, significant differences in the GRS‐measured silica in Amazonian volcanoes and in martian meteorites of equivalent age result from contamination by silica‐rich dust and are problematic for a silica trend. Comparison of FeO* in Noachian and Amazonian surface data shows no decrease. An inferred temporal trend in thorium is in conflict with the complex enrichment and depletion patterns of incompatible trace elements in martian meteorites of various ages. A dearth of analyses of Hesperian‐age surface rocks precludes a firm evaluation of inferred Noachian‐Hesperian trends and Hesperian‐Amazonian trends, but abundant Noachian rocks and a few Hesperian rocks at rover sites, and Amazonian martian meteorites, collectively representing at least 16 surface locations, afford useful comparisons with orbital remote‐sensing data.