bluuebunny/crossref_metadata_2025_split huggingface dataset:
Oxytocin infusion for maintenance of uterine tone under prophylactic phenylephrine infusion for prevention of post-spinal hypotension in cesarean delivery: a prospective randomised double-blinded dose-finding study.
Authors: Jin Xiao-Qin , Shen Yao-Hua , Fu Fan , Yu Juan , Xiao Fei , Huang Xiao-Dong 
Published: September 2023

Abstract
Background:
Prior studies have shown that, when administered as an intravenous bolus to prevent uterine atony, prophylactic phenylephrine infusion increased the dose requirement of oxytocin and second-line uterotonics. For the prevention of uterine atony, oxytocin should be delivered by continuous infusion. Here, we aimed to determine the ED50 and ED90 parameters (the effective doses for 50% and 90% patients without uterine atony) of oxytocin for co-infusion with prophylactic phenylephrine during cesarean delivery.
Methods:
In this prospective randomized double-blinded dose-finding study, one hundred patients were divided into four groups to receive 2.5, 5.0, 7.5, or 10 IU/h oxytocin infusion, after the umbilical cord was clamped during the study period. The uterine tone was evaluated and defined as either adequate or inadequate. Probit regression analysis was applied to calculate the ED50 and ED90 of oxytocin infusion. Uterine tone, the percentage of patients who needed additional oxytocin bolus, second-line uterotonics, side effects, estimated blood loss, and neonatal outcomes were monitored.
Results:
The estimated ED50 and ED90 values of the oxytocin infusion doses for the prevention of uterine atony were 1.9 IU/h (95% CI -4.6-3.8) IU/h and 9.3 IU/h (95% CI 7.3-16.2) IU/h, respectively. Across groups, there was a significant linear trend between the infusion dose and the percentage of patients who required additional oxytocin (p-value = 0.002). No differences were observed in the incidence of side effects and neonatal outcomes.
Conclusion:
Under the conditions of this study, the ED90 of oxytocin infusion for the prevention of uterine atony was 9.3 IU/h, which is higher than the current recommendation. This finding is helpful for clinical practice, because of the routine use of phenylephrine in cesarean delivery. Further studies are needed to determine the appropriate initial bolus of oxytocin after neonatal delivery.
Trial registration:
The study was registered on the Chinese Clinical Trial Register (register no. ChiCTR2200059556).
RUL: https://www.chictr.org.cn/showproj.html?proj=153116
Key elements and contextual factors that influence successful implementation of large-system transformation initiatives in the New Zealand health system: A realist evaluation
Authors: Sharma Kanchan M , Jones Peter B , Cumming Jacqueline , Middleton Lesley 
Published: September 2023

Abstract
Background
Despite three decades of policy initiatives to improve integration of health care, delivery of health care in New Zealand remains fragmented, and health inequities persist for Māori and other high priority populations. An evidence base is needed to increase the chances of success with implementation of large-system transformation (LST) initiatives in a complex adaptive system.
Methods
This research aimed to identify key elements that support implementation of LST initiatives, and to investigate contextual factors that influence these initiatives. The realist logic of enquiry, nested within the macro framing of complex adaptive systems, formed the overall methodology for this research and involved five phases: theory gleaning from a local LST initiative, literature review, interviews, workshop, and online survey. We explained variations in success (outcomes) by identifying mechanisms triggered by various contexts in which LST initiatives are implemented.
Results
The research found that a set of 10 key elements needs to be present in the New Zealand health system to increase chances of success with implementation of LST initiatives. These are: (i) an alliancing way of working; (ii) a commitment to te Tiriti o Waitangi; (iii) an understanding of equity; (iv) clinical leadership and involvement; (v) involved people, whānau, and community; (vi) intelligent commissioning; (vii) continuous improvement; (viii) integrated health information; (ix) analytic capability; and (x) dedicated resources and time. The research identified five contextual factors that influenced implementation of LST initiatives: a history of working together, distributed leadership from funders, the maturity of Alliances, capacity and capability for improvement, and a continuous improvement culture.
Conclusions
Use of informal trust-based networks provided a critical platform for successful implementation of LST initiatives in the New Zealand health system. Maturity of these networks depends on the key mechanism of trust, that is built and nurtured over time through sharing of power by senior health leaders by practising distributed leadership. The role of central agencies and government is to provide the policy settings and conditions in which trust-based networks can flourish. The evidence base for successful implementation of LST initiatives produced in this research is transferrable to other regions and countries.
Individual Differences in Working Memory and the Impact on Students' Achievements in Solving Mathematical Problems in Analytic Geometry
Authors: Cohen Tirza , Paz-Baruch Nurit 
Published: September 2023

Abstract
The study explored the contribution of working memory (WM) components to analytic geometry achievements. According to Baddeley & Hitch’s (1974) Multicomponent Model, WM consists of three components: a phonological loop, a visuo-spatial sketchpad, and a central executive system. Few studies have focused on the role of WM mechanisms in analytic geometry. The participants in this study were 92 high school students (10th–11th grades). All students were tested on an analytic geometry test that included problems on three levels of difficulty. Additionally, the participants were tested on a battery of five memory tests that included all three components of WM. The findings suggest that after controlling for the grade level and the students' math scores, the central executive system accounted for 13% of the variance in analytic geometry, while the visuo-spatial sketchpad accounted for 7.9% of the variance. However, the phonological loop had no significant effect on students' achievements in analytic geometry. The results showed that students with a higher WM capacity also achieved better results at each level of difficulty on the analytic geometry test. The study’s findings may contribute to an understanding of the complex relationship between WM mechanisms and analytic geometry. The results can contribute to the theoretical knowledge regarding the correlation between the level of difficulty of a mathematical task and WM. Directions for future research and implications for practice are discussed.
Downregulation hsa_circ_0006620 inhibit the malignant progression of prostate cancer by regulation miR-502-3p/HK2 axis mediated aerobic glycolysis
Authors: Li Xue , Wang Menghan , Luo Yulin , Huang Qingqing , Huang Gang , Jin Mingming 
Published: September 2023

Abstract
Background: Circular RNAs (circRNA) are a class of covalently closed single-stranded RNAs that have been implicated in cancer progression by regulation metabolism. But, the circRNA roles in prostate cancer remains unknown.
Methods: This research aimed to use FISH and RT-qPCR to investigate hsa_circ_0006620 expression in prostate cancer cells and tissues after high-throughput sequencing. Our team made the luciferase reporter assay to validate hsa_circ_0006620 downstream target. Transwell migration assay, 5-ethynyl-20-deoxyuridine, and cell counting kit-8 were applied to investigate both proliferation and migration. In vivo tumorigenesis and metastasis assays were performed to investigate the hsa_circ_0006620 role in prostate cancer.
Results: The outputs elucidated that hsa_circ_0006620 expression incremented in prostate cancer cells and tissues. Hsa_circ_0006620 downregulation inhibited prostate cancer cell proliferation as well as migration in in vivo and in vitro experiments. The luciferase results validated that miR-502-3p and HK2 were hsa_circ_0006620 downstream targets. HK2 overexpression or miR-502-3p inhibition reversed prostate cancer cell migration after hsa_circ_0006620 silencing. The study also found that overexpression of HK2 or inhibition of prostate cancerreversed aerobic glycolysis after hsa_circ_0006620silencing.
Conclusion: Results demonstrate that hsa_circ_0006620 downregulation inhibits prostate cancer malignant progression by regulation miR-502-3p/HK2 axis mediated aerobic glycolysis.
Management of patients undergoing coronary angiography or percutaneous coronary interventions through the left distal trans-radial artery approach compared to the right conventional trans-radial artery approach
Authors: Elyamany Ehab , Galal Ayman , Abdelhady Yasser 
Published: September 2023

Abstract
Background
Lately, the alternative optimal approach for the access of the coronary artery was made through the left distal radial artery, either for diagnostic or interventional purposes. This study aimed to compare the safety and efficacy of the left distal trans-radial (ld-TRA) and conventional right trans-radial (RTRA) approaches for coronary procedures.
Patients and Methods:
This prospective cohort study was conducted on 100 patients who underwent coronary angiography and/or PCI in the Department of Cardiology of Beni-Suef University Hospital. Fifty patients underwent conventional right trans-radial access. The other fifty underwent left distal trans-radial approach from October 2018 to October 2019. The primary clinical outcomes were the complications at the blood vessel access site and the major induced adverse cardiac events. The secondary outcomes were the puncture time, the procedure time, the coronary cannulation time, the amount of dye injected, and the fluoroscopy time.
Results
there was an insignificant lower rate of crossover and complications in the ldTRA than in the RTRA. The coronary cannulation time was significantly lower in ldTRA (30 ± 7 seconds) than in RTRA (43 ± 11 seconds). Also, there was insignificant lower puncture time, duration of the procedure, amount of dye, and fluoroscopy time in the ldTRA than in the RTRA.
Conclusion
The access technique of the distal left radial artery is considered feasible and safe access for coronary interventions and angiography, with only a minor advantage over the right radial approach adding the benefit of the preservation of the radial artery for further revascularization procedures when needed.
Correlation between PRSS23 and Prognosis and Immune Regulation in Pancreatic Cancer
Authors: wang jingjing , deng zhe 
Published: September 2023

Abstract
Pancreatic cancer (PC) is a highly deadly solid malignant tumors with disrespectful prognosis, making appropriate biomarkers determination extraordinary crucial. Immune infiltration in tumor microenvironment is related to the subsistence of patients in PC. It has not been elaborated that the relationship between serum protease 23 gene (PRSS23) gene and the PC. We first determined the PRSS23 expression and its possible biological roles in PC, then analyses the TCGA and GEO data sets to check the possible carcinogenic effects of PRSS23.Moreover, the clinical value of PRSS23 was clarified through Kaplan-Meier Cox regression and prognostic nomogram model in PC. To examine the possible biological roles of PRSS23, GO analysis and KEGG analyses were accomplished. Using Tumor Immunity Estimation Resource (TIMER), We discover that the PRSS23 expression was raised in the PC tissue compared to corresponding non-cancerous tissue. High-PRSS23 expression is bound up with worse clinical pathological characteristics and worse prognosis in the PC. The correlation between PRSS23 and tumor infiltration was determined in tumor microenvironment (TME). Furthermore, functional enrichment analysis shows that PRSS23 may make a difference in impacting TME, cell adhesion and migration in PC tumor cell. This study maybe the first across-the-board discussion to reveal that the PRSS23 can be used as a new type of biomarker linked with immune infiltration and enlighten latent treatment targets in PC treatment.
Exploring key determinants of health among individuals with serious mental illness: Qualitative insights from a first episode psychosis cohort, 20 years postdiagnosis
Authors: Skjærpe Jorunn Nærland , Hegelstad Wenche ten Velden , Joa Inge , Storm Marianne 
Published: September 2023

Abstract
Background
Individuals with serious mental illness (SMI) are more likely to experience functional decline, low well-being, comorbidities, shorter lifespan, and diminished quality of life than the general population. This qualitative study explores determinants of health that individuals with SMI perceive as important to their health, well-being, and ability to live a meaningful life.
Method
We conducted interviews with 13 individuals with early detected first episode psychosis as part of a 20-year follow-up study of a larger cohort. Interview data were analyzed using qualitative content analysis.
Results
Analysis identified two themes comprising eight categories representing determinants of health. The first theme reflected management of mental and physical health. Categories in this theme were: access to mental healthcare adapted to individual needs, strategies during deterioration, use of psychotropic medication, maintenance of physical health and lifestyle. The second theme reflected social health determinants in coping with mental illness and comprised three categories: family and friends, engaging in meaningful hobbies and activities, and the influence of employment on mental health.
Conclusions
Individuals with SMI outlined mental, physical, and social determinants of health that were important for their health, well-being and ability to live a meaningful life. In future clinical practice, coordinated care addressing the complexity of health determinants will be important.
A Case-control study on the risk factors associated with the occurrence of non-tuberculous Mycobacte ria pulmonary disease in bronchiectasis patients
Authors: Feng Yinping , Guo Jing , Luo Shuirong , Zhang Zunjing 
Published: September 2023

Abstract
Objective To analyze the risk factors of bronchiectasis associated with non-tuberculous mycobacteria pulmonary disease, and provide basis for more effective prevention and treatment of BCS combined with NTM-PD.Methods The patients with bronchiectasis admitted to the infection department from January 2021 to June 2023 were selected as the study subjects, 34 patients with non-tuberculous mycobacteria pulmonary disease as the observation group, and 52 patients with simple bronchiectasis as the control group. Collect basic information, imaging features, serum albumin, and infection indicators from two groups of patients. Using univariate and multivariate logistic regression analysis to analyze the risk factors of NTM-PD in BCS patients.Results Multivariate logistic regression analysis showed that the acute exacerbation of bronchiectasis no less than 2 times a year (OR = 3.884, 95% CI: 1.200-12.568), number of bronchiectasis involved lung lobes no less than 3 pieces (OR = 3.932, 95% CI: 1.208–12.800), hypoalbuminemia (OR = 3.221, 95% CI: 1.015–10.219), and the NLR index (OR = 1.595, 95% CI: 1.200-2.119) were risk factors for bronchiectasis with non-tuberculous mycobacteria pulmonary disease (P < 0.05).Conclusion Patients with acute bronchiectasis no less than 2 times a year, number of bronchiectasis involved lung lobes no less than 3 pieces, hypoalbuminemia, and bronchiectasis with elevated NLR are more likely to be accompanied by non-tuberculous mycobacteria pulmonary disease, which should be prevented and treated as soon as possible.
Performance evaluation of a substituted topography-based model to forecast rainfall and tide-induced lowland flooding
Authors: HUANG PIN-CHUN 
Published: September 2023

Abstract
A variety of factors such as rainfall distribution, downstream tide levels, upstream contributing areas, and terrain characteristics can affect the level of flooding disasters. The objective of this study is to build a hybrid model that combines the analysis of hydrological and geomorphological factors in the catchment with machine learning algorithms to efficiently provide flooding information and simultaneously eliminate the problem of numerical instability. Various environmental factors are investigated to determine the model inputs used to forecast the spatial distribution of inundation depths by running the proposed AI-based hybrid model. The main contribution of the proposed model is to apply informative indexes for preprocessing a large amount of input data before model training to enhance the accuracy in forecasting inundation depths. Another approach of preprocessing input data by using a classification algorithm, known as the self-organizing map (SOM) network, is also adopted and discussed to emphasize the physical significance of the proposed methodology. On the other hand, to provide reliable inundation-depth data for the stage of model training, a numerical integration model based on theoretical governing equations for floodplain simulations in lowlands is also applied in this study. The proposed methodology can be deemed an alternative for real-time coastal flooding simulation and forecast because of its advantages in efficiency, stability, and predicted accuracy.
Mucosal prime-boost immunization with live murine pneumonia virus-vectored SARS-CoV-2 vaccine is protective in macaques
Authors: Buchholz Ursula , Kaiser Jaclyn , Nelson Christine , Liu Xueqiao , Park Hong-Su , Matsuoka Yumiko , Luongo Cindy , Santos Celia , Ahlers Laura , Herbert Richard , Moore Ian , Wilder-Kofie Temeri , Moore Rashida , Walker April , Lijuan Yang , Munir Shirin , Teng I-Ting , Kwong Peter , Dowdell Kennichi , Nguyen Hanh , Kim JungHyun , Cohen Jeffrey , Johnson Reed F. , Garza Nicole , Via Laura , Barber Daniel , NOUEN CYRIL LE 
Published: September 2023

Abstract

Immunization via the respiratory route is predicted to increase the effectiveness of a SARS-CoV-2 vaccine. We evaluated the immunogenicity and protective efficacy of one or two doses of a live-attenuated murine pneumonia virus vector expressing SARS-CoV-2 prefusion-stabilized spike protein (MPV/S-2P), delivered intranasally/intratracheally to rhesus macaques. A single dose of MPV/S-2P was highly immunogenic, and a second dose increased the magnitude and breadth of the mucosal and systemic anti-S antibody responses and increased levels of dimeric anti-S IgA in the airways. MPV/S-2P also induced S-specific CD4+ and CD8+ T-cells in the airways that differentiated into large populations of tissue-resident memory cells within a month after the boost. One dose induced substantial protection against SARS-CoV-2 challenge, and two doses of MPV/S-2P were fully protective against SARS-CoV-2 challenge virus replication in the airways. A prime/boost immunization with a mucosally-administered live-attenuated MPV vector could thus be highly effective in preventing SARS-CoV-2 infection and replication.
Research on the maintenance system of farmland water conservancy facilities based on the consciousness evolution model
Authors: liu chuang , Dai XiaoPing , Li JinGang , Ding Zhe 
Published: September 2023

Abstract
Irrigation and drainage engineering is a safeguard for agricultural production, and the management and maintenance of its terminal channels and ancillary works are often the responsibility of village collectives, water user associations, and other organizations. However, farmers generally lack the enthusiasm to participate in maintenance and management, coupled with a lack of capital investment, the relevant engineering maintenance difficulties. Therefore, how to establish a sustainable and stable farmland water conservancy facility maintenance management system is a major problem. For this reason, this paper establishes an "awareness evolution model" based on the theory of cultural multilevel selection, embeds the social system simulated by this model into the dike agricultural system through the method of Multi-agents, and simulates the evolution of awareness change and the agricultural system under different dike initial height scenarios. The results show that proper exposure of agricultural systems to flood risks can reduce the flood losses suffered by agricultural systems, and the social factors behind them are discussed. Further, how to establish a set of sustained and stable social maintenance management systems for farmland water conservancy is explored, and relevant suggestions are given.
Fairness Resource Allocation Based on Blockchain for Secure Communication in Integrated IoT
Authors: Liang Wei , Zhao Jun , Liu Yan , Liang Yan , Li Jingwen 
Published: September 2023

Abstract
The emerging Space-Air-Ground, Artificial intelligence (AI), blockchain and Vehicle-toeverything (V2X) technology in Integrated Internet of Things (IoT) enables vehicles to communicate with other vehicles and roadside units (RSU), which improves communication efficiency and driving safety. Due to the rich data in the Integrated IoT, it is easy for illegal persons to steal data or deceive users. While reasonably allocating resources to complete the transmission task, it is still a challenge to ensure the communication security of vehicle users in Integrated IoT. In this paper, we study the cost of vehicle users transmitting tasks by Vehicle to Infrastructure (V2I) and Vehicle to Vehicle (V2V) in Integrated IoT. In order to protect the information security, we establish the identity authentication and matching model to obtain a better channel environment of Integrated IoT. Moreover, we consider dynamic pricing based on bandwidth resource occupancy to ensure user experience and server load in Integrated IoT. Under the constraints of task tolerable delay, we fix the bandwidth on the V2V side and decouple the task decomposition and bandwidth allocation in Integrated IoT. Then, we propose algorithms Blockchain based Vehicle Identity Authentication (BVIA) and Delay Weight Fairness Bandwidth Allocation (DWFBA). In this way, vehicle users and RSUs entering the Integrated IoT system are authenticated and matched with devices with good trust value, and the fairness of users resource allocation is guaranteed. Simulation results show that BVIA algorithm can reduce communication overhead, DWFBA algorithm can control user costs, and effectively reduce the number of task failures in Integrated IoT.
Resilience Analysis of the Local Communities from a Political Economy Perspective in the Central Region of Zanjan
Authors: Zarghami Saeid , Kaleji Lotfali Kozehgar , Abhari Maryam 
Published: September 2023

Abstract
Local community resilience has been a solution to reduce human and natural origin damages for several decades in global studies. Various studies have addressed different aspects of resilience. However, the concept of resilience, especially in developing countries such as Iran, which has a rent-based economy and relies on oil, needs attention to other dimensions of resilience. In these countries, the institutional environment is highly influenced by political economy, and political economy affects all aspects of planning and governance systems. This study evaluates the resilience of the central region of Zanjan in terms of institutional environment, physical structure, and residents' perspectives. The method of research is mixed. Qualitative analysis was evaluated for institutional environment. It is also quantitative analysis was investigated to measure physical vulnerability and resilience. The results show that the resilience situation is relatively low. The policy-making influenced by political economy, in addition to increasing social and physical damages in this region, leads to the formation of rent housing, a decrease in social capital, an increase in poverty, and ultimately a decrease in the resilience of the central region of Zanjan. Therefore, to create resilience, we need to transition from the current institutional environment and take steps towards institutional evolution and development.