bluuebunny/crossref_metadata_2025_split huggingface dataset:
Therapy Compliance of Type-2 Diabetes Mellitus Patients Before and During The Covid-19 Pandemic: A Systematic Review
Authors: Noor Arasyi Hidtsa Aqila , Razantira Dimas Luthfi , Rizqiyah Fina Jazilah , Prasetya Salsabilla Zahra , Ernadiyanto Defo Aro , Utomo Budi 
Published: June 2023

Medical compliance is a key aspect in the management of multiple-modalities therapies, such as those found in patients with type-2 diabetes mellitus. Aspects such as healthcare accessibility, complications or secondary ailments, lifestyle, socioeconomic status, and academic status can affect a patient’s compliance, thus their therapeutic outcomes. The Covid-19 pandemic brought various observable shifts toward these aspects which raises the need for further evaluation regarding type-2 diabetes mellitus therapy compliance during the Covid-19 pandemic. This study is a systematic review that uses secondary data gathered from articles published in Pubmed, ScienceDirect, and Google Scholar with publication dates ranging from January 2018 until October 2021. Using the PRISMA algorithm and JBI critical appraisal questionnaire, we selected 10 controlled studies that discussed therapy compliance of Type-2 Diabetes Mellitus patients before the Covid-19 pandemic and 7 studies that discussed therapy compliance of Type-2 Diabetes Mellitus during the Covid-19 pandemic. There was a notable difference between the therapy compliance profile of Type-2 Diabetes Mellitus patients before and during the Covid-19 pandemic. Pharmacotherapy compliance during the Covid-19 pandemic showed a moderate-high trend whereas the trend before the Covid-19 pandemic was moderate-low. Compliance of physical activity and diet modification related to Type-2 Diabetes Mellitus respectively showed a moderate-high and moderate-low trend during the Covid-19 pandemic, whereas the trend before Covid-19 pandemic was low. A notable shift was found between the therapy compliance profile of Type-2 Diabetes Mellitus patients before and during the Covid-19 pandemic. Further meta-analysis study is required to measure the significance of this shift as well as their correlations. Additional studies are also required to isolate the factors that may contribute to this shift.
Deciphering the Coagulation Factors in Pulmonary Embolism Incident-Based Thorax Enhanced Chest CT in COVID-19 Patient
Authors: Pratiwi Wan Betty , Soeroso Noni Novisari , Tarigan Setia Putra , Abdullah Muntasir , Sembiring Rosita Juwita , Icksan Azizah Ghanie , Lubis Netty Delvrita , Eyanoer Putri Chairani 
Published: June 2023

Introduction: Pulmonary embolism is associated with coagulopathy in COVID-19. It is one of the causes of death in COVID-19 cases and is often underdiagnosed in Indonesia because computed tomography-pulmonary angiography (CTPA) is not used as the gold standard. T
Methods: This study used a prospective analytical design with a cross-sectional approach. The study participants were 45 COVID-19 patients admitted to Santa Elisabeth Hospital, Medan, from January to March 2021. Patients were identified with moderate to severe degrees of COVID-19 and elevated D-dimer and subsequently instructed to undergo a thorax CT scan with IV contrast. The data was analyzed using dependent t-test statistical analysis. The p-value < 0.05 was noted as significant.
Results: Moderate to severe coagulation factor values in COVID-19 patients with mean + SD PT, APTT, D-dimer, fibrinogen, and platelets were 14.11; 30.65; 1172.14; 423.56 and 215.822, respectively. In this study, 22 (48.9%) patients experienced a pulmonary embolism, while the other 23 (51.1%) did not. No significant correlation was found between all coagulation factors and embolism (p > 0.05). The mean + SD well score for pulmonary embolism was 0.23 + 0.57.
Conclusion: Pulmonary embolism was detected in 22 patients (48.49%) with moderate to severe COVID-19 who developed hypercoagulation as indicated by the thorax CT scan with IV contrast. This case was quite common. In resource-constrained situations, a thorax CT scan with IV contrast may replace CTPA in diagnosing/detecting the presence of pulmonary embolism.
Educação e Inovação Social: A Formação Recíproca
Authors: Ferreira Batista Leonardo , Helal Diogo Henrique 
Published: June 2023

Contexto do caso: Este caso para ensino discute a relação entre educação e inovação social, a partir de um dos episódios da série brasileira de documentários “Destino: Educação – Escolas Inovadoras” (Canal Futura), veiculada pela Globoplay, refletindo como a educação está associada à inovação social na prática. O documentário referido aborda o Projeto Âncora, escola localizada em Cotia/SP, em função de suas características inovadoras em destaque no contexto brasileiro.
Dilema do Caso: Com uma perspectiva freireana de aprendizagem transformativa, o caso, ao enfatizar uma Educação autônoma que contribui para a emancipação dos envolvidos, busca responder ao seguinte dilema: “A Educação pode gerar inovação social?”.
Fechamento do caso: As iniciativas discutidas permitem encaminhar a discussão nos dois sentidos: da Educação para a inovação social e vice-versa. Docentes de Ensino Superior em Administração, Gestão Pública, Pedagogia e cursos afins podem utilizar o caso em disciplinas que trabalhem direta ou indiretamente as temáticas discutidas.

Palavras-chave:Educação, Inovação Social, Abordagem Freireana, Mudança Social, Caso para Ensino.
The effects of culture-expanded, non-cryopreserved adipose tissue mesenchymal stem cells (AT-MSCs) on neurological and immunological paradigms in females with secondary progressive multiple sclerosis: a phase I/II clinical trial
Authors: Arab Fahimeh Lavi , Yousefi Forouzan , Naderi-Meshkin Hojjat , Mirahmadi Mahdi , Nikkhah Karim , Amiri Houshang , Erfani Marjan , Ayoobi Fatemeh , Tabasi Nafiseh Sadat , Nikkhah Ali , Mahmoudi Mahmoud 
Published: June 2023

Abstract
Objective
Mesenchymal stem cells (MSCs) due to their immunomodulatory, neurogenerative and self-renewal features have achieved fascinating prospects in regenerative medicine. Adipose tissue is an optimal source of MSCs because of the high abundance and high proliferative rate of MSCs in this tissue. To date, MSCs utilized for curing of MS have been cryopreserved, almost derived from bone marrow, and infused at standard doses (1–2×106 cell/Kg).
Methods
Here, we explored the safety, tolerability and functionality of fresh and high dose (4.4×106 cell/Kg) autologous adipose tissue MSCs (AT-MSCs) in 10 female patients with secondary progressive MS (SPMS, EDSS = 4–6). To this end, we assessed adverse events of AT-MSCs administration 9 months following transplantation. Additionally, we measured the number and volume of lesions, as well as the number of contrast-enhancing lesions from magnetic resonance imaging (MRI) data. Furthermore, we evaluated the expanded disability status scale (EDSS), depression, and quality of life status of the patients over 9 months. Also, the immunomodulatory effect of MSCs was investigated by evaluating gene expression of inflammatory (IL1, IL6, IL17, IFN-γ) and anti-inflammatory (TGF-β, IL4, IL10, FOXP3) cytokines besides the proportion of peripheral blood T regulatory cells as important modifier cells in hemostasis of autoimmune responses in MS diseases.
Results
In our study, high doses of non-cryopreserved AT-MSCs were successfully administrated into 10 SPMS patients during two injections seven days apart. Our findings have shown that AT-MSCs have no serious side effects after one year. Furthermore, we noted the efficacy of AT-MSCs in terms of reduction of numbers and volume of T2-FLAIR lesions, ameliorating of EDSS, and improvement in psychological criteria. Moreover, the immunomodulatory effects of AT-MSCs were confirmed by enhancing of Tregs population and anti-inflammatory cytokines as well as lowering inflammatory cytokines in patients.
Conclusion
Administration of high-dose (4.4×106 cell/Kg) of non-cryopreserved autologous adipose tissue MSCs (AT-MSCs) is safe and tolerated well in SPMS patients. Furthermore, AT-MSCs can be considered as an efficient treatment to stop or even reverse neurological manifestations in the progressive phase of multiple sclerosis.
Trial registration
: This clinical trial study was registered with the Iranian Registry of Clinical Trials (Reference: IRCT20091127002778N1 at 2018-01-10).
New insights on ENSO teleconnection asymmetry and ENSO forced atmospheric circulation variability over North America
Authors: Sutton Margaret , Larson Sarah , Becker Emily 
Published: June 2023

Abstract
El Niño-Southern Oscillation (ENSO)-related sea surface temperature variability in the eastern equatorial Pacific drives an extratropical large-scale atmospheric response. The atmospheric response is a key driver of global climate variability, with the strongest impact occurring during Northern Hemisphere winter. The degree to which atmospheric circulation variability is altered during ENSO events, in comparison with atmospheric circulation variability during ENSO-neutral conditions, is the focus of this study. Two multi-century, CESM1-CAM4 simulations are compared: a fully coupled experiment (CTRL), and a partially decoupled experiment in which ENSO is dynamically suppressed (NoENSO) so that the mean state is not biased towards a particular ENSO phase. We present evidence that the rectification of ENSO and its teleconnections onto the mean state lead to an underestimation of the asymmetry of ENSO teleconnections. Analyses also show that ENSO displaces 500hPa geopotential height (Z500) variability away from the central northern U.S. and southern Canada, resulting in less variability during ENSO years than ENSO-neutral years. Additionally, we find that estimating the ENSO-forced change in Z500 variance compared to ENSO-neutral years requires a surprisingly large sample of ENSO-neutral years. The results imply that a substantially longer record–roughly an order of magnitude longer in length–is needed to fully capture the statistics of ENSO’s teleconnected impacts over North America than suggested in previous studies.
Two-step diagnostic method in diagnosing periodic fever with aphtha stomatitis, pharyngitis and lymphadenitis, a practice from China
Authors: Liang Cong , He Zhen , A Yong-fu , Chen Jun-Zhu , Zeng Wei-kun , Jin Hui , Tao Shu-yu , Li Yu , Ke Zhi-Yong 
Published: June 2023

Abstract
Objective
Periodic fever with aphtha stomatitis, pharyngitis and lymphadenitis (PFAPA) is an inflammatory disease characterized by recurrent fever, which mainly affects children and has a high rate of missed diagnosis in China. This study is set to summarize the clinical features of PFAPA children and to develop a feasible diagnostic method.
Methods
Base on our previous experience, a two-step method consisting of preliminary assessment with disease recognition and subsequent verification was used when diagnosing PFAPA in children. The clinical data of the PFAPA children diagnosed from June 17, 2020 to November 3, 2022 were collected and summarized, and the two-step diagnostic method was validated according to the CARRA-PFAPA diagnostic criteria.
Results
A total of 260 children with periodic fever were included in this study, 8 of them did not meet the criteria of suspected PFAPA. Of the rest, 29 lost follow-up and 9 had no more episode during follow-up. One child was excluded from PFAPA by prednisone trial. The children diagnosed with PFAPA had recurrent fever beginning at a median age of 30 months, but diagnosis was made at 13 months later. The cycle duration was 30 days and the attack lasted 4 days. Exudative tonsillitis, oral ulcer, cervical adenitis and abdominal pain were presented in 93.6%, 51.4%, 43.9% and 33.1%, respectively. Leukocytosis and elevated C-reactive protein were presented in 88.6% and 91.2% of the children during fever episode, and all returned to normal when reexamined in the interval. Cytokines were detected in 36 cases during episodes, interleukin-6 increased in all cases, interferon-γ increased in most cases, but all returned to normal during asymptomatic interval. The height and weight of the children were lower than those of normal. 39.5% of the children had a positive family history. If criteria “normal growth and development” removed, only 15 of the 213 children diagnosed with PFAPA did not fulfill the CARRA-PFAPA criteria for less than 6 episodes at the time diagnosing, but all up to the standards in follow-up.
Conclusion
PFAPA should be considered for children with recurrent fever, especially those with tonsil exudation. The two-step diagnostic method provides the indications for corticosteroid use, and thus may be appropriate in clinical practice.
Non-equilibrium dynamics of spin-lattice coupling
Authors: Staub Urs , Ueda Hiroki , Mankowsky Roman , Paris Eugenio , Sander Mathias , Deng Yunpei , Liu Biaolong , LeRoy Ludmila , Nag Abhishek , Skoropata Elizabeth , Wang Chennan , Ukleev Victor , Perren Gérard Sylvester , Dössegger Janine , Gurung Sabina , Abreu Elsa , Savoini Matteo , Kimura Tsuyoshi , Razzoli Elia , Patthey Luc , Lemke Henrik , Johnson Steven 
Published: June 2023

Abstract
Collective excitations that involve both vibrational and magnetic characters, arising from strong coupling between the lattice and spins, are of fundamental interest in ultrafast manipulation of magnetization. Although previous experimental studies have successfully observed the spin dynamics of a coherent electromagnon that reflects this coupling, the associated atomic motions have not been directly observed. Here we use time-resolved X-ray diffraction to directly measure both the ultrafast structural motion and the associated spin dynamics following the excitation of a coherent electromagnon by an intense THz pulse in a multiferroic hexaferrite. Comparing the dynamics of the two different components, one striking outcome is the different phase shifts relative to the driving field, gives deeper insights into the excitation process of electromagnons. The observation of combined lattice and magnetization dynamics of the electromagnon resonance paves the way to access the magnetoelectric coupling strength in ultrafast timescales, which remains a missing fundamental parameter for ultrafast control of magnetism.
A case series on recurrent and persisting IgA vasculitis (Henoch Schonlein purpura) in children
Authors: Marro Julien , Williams Chloe E.C , Pain Clare E , Oni Louise 
Published: June 2023

Abstract
Background
IgA vasculitis (IgAV) is a small vessel vasculitis that is more common in childhood. Very limited evidence exists on patients who experience an atypical disease course. The aim of this study was to describe a cohort of children diagnosed with recurrent or persisting IgAV to identify any themes associated with their disease course and areas of unmet needs.
Methods
A single centre retrospective study of children diagnosed with recurrent or persisting IgAV at Alder Hey Children’s Hospital (Liverpool, UK). Clinical data, including features at presentation and during follow up, potential triggers, abnormal laboratory and histology results, treatment and outcome at last clinical review were retrospectively collected. Key themes were identified.
Results
A total of 13 children met the inclusion criteria (recurrent disease, n = 4; persisting disease, n = 9). Median age at first presentation was 10.2 years [2.6–15.5], female:male ratio 1.2:1. Children in the atypical cohort were significantly older than a larger cohort of children who followed a non-complicated disease course (median age 5.5 years (range [0.6–16.7], p = 0.003). All children re-presented with a purpuric rash (either recurring or persisting), accompanied by joint involvement in 92% of patients (12/13). Disease-modifying anti-rheumatic drugs (DMARDs) were used in 8/13 (62%) children. The median time from first presentation to diagnosis of atypical disease was 18.4 months [5.3-150.8] and the time from first presentation to treatment was 24.1 months [1.8–95.4]. Use of corticosteroids was significantly higher in children with renal involvement (p = 0.026). During follow up, 8/13 (62%) children were admitted at least once, whilst 10/13 (77%) had re-presented at least once to the emergency department. Five (38%) children were referred to psychology services and 7 (54%) children reported feelings of frustration.
Conclusions
This series describes some characteristics of a small cohort of children with atypical IgAV. It also identifies unmet needs in children with atypical IgAV, which includes delays in diagnosis and lengthy waits for treatment, lack of high-quality evidence regarding treatment choices and a high unrecognised disease burden. Further research is needed to study this subgroup of children as evidence is lacking.
Optimization of Multi-Objective Process Parameters of TIG-MIG Hybrid Welding On EN24 Mild Steel Material Using the Grey-Based Taguchi Method
Authors: Tesfaye Fasil Kebede , Getaneh Ayitenew Mogninet 
Published: June 2023

Abstract
Metal Industry and Machine Technology Development Enterprise is Ethiopia's leading manufacturing industry, producing a diverse range of industrial machinery and products. The main welding process used to join the products is MIG welding, which has several flaws, including low weld-metal toughness, spatter formation, undercut formation, and finally poor tensile strength and toughness. The company also uses TIG welding, which uses an inert gas to produce less smoke and fumes. While this technology produces precise welds, it is a time-consuming operation with a lower production rate. As a result, a special type of welding process is required that incorporates the properties of both types of welding processes. As a result, the hybrid TIG-MIG welding configuration was proposed. The optimization of process parameters of EN24 mild steel material for TIGMIG hybrid welding is presented in this paper. The test was carried out on a 6 mm EN24 mild steel plate. The butt joint configuration was used. MIG welding current, TIG welding current, MIG welding voltage, TIG welding voltage, and welding gun travel speed were used as process parameters. A single-level L27 orthogonal array is used to optimize process parameters. Tensile and hardness tests are used to evaluate the mechanical properties of the weld joint. The optimum level setting of the test, according to the mean effect plot of GRG, is MIG welding current of 200 A, MIG welding voltage of 15 V, TIG welding current of 200 A, TIG welding voltage of 18 V, and welding gun travel speed of 5 mm/s. The significant process parameters were investigated using ANOVA. MIG welding current and MIG welding voltage were significant factors in the ANOVA, with percentage contributions of 44.19% and 49.20%, respectively. Five confirmation tests were performed, and the results show that the mean grey relational grade of the conformation test was 0.7594, which falls within the 90% confidence interval, indicating that the experiment is reliable. Finally, MIG welding, TIG welding, and TIG-MIG hybrid welding processes were compared, with the results indicating that TIG-MIG hybrid welding has the highest hardness and tensile strength of all. Based on the findings, it is possible to conclude that the company should use the hybrid welding method to improve the weld joint's hardness and tensile strength.
Identification of gene regulatory networks affected across drug-resistant epilepsies
Authors: Aronica Eleonora , Romagnolo Alessia , Mills James , Anink Jasper , Godard Patrice , Rajman Marek , Mühlebner Angelika , Skelton Andrew , Eyll Jonathan van , Dedeurwaerdere Stefanie , François Liesbeth 
Published: June 2023

Abstract
Epilepsy is a chronic and heterogenous disease characterized by recurrent unprovoked seizures, that are commonly resistant to antiseizure medications. This study is the first to apply a transcriptome network-based approach across epilepsies aiming to improve understanding of molecular disease pathobiology, recognize affected biological mechanisms and apply causal reasoning to identify novel therapeutic hypotheses. This study included the most common drug-resistant epilepsies (DREs), such as temporal lobe epilepsy with hippocampal sclerosis (TLE-HS), and mTOR pathway-related malformations of cortical development (mTORopathies). This systematic comparison characterized the global molecular signature of epilepsies, elucidating the key underlying mechanisms of disease pathology including neurotransmission and synaptic plasticity, brain extracellular matrix and energy metabolism. In addition, specific dysregulations in neuroinflammation and oligodendrocyte function were observed in TLE-HS and mTORopathies, respectively. The aforementioned mechanisms are proposed as molecular hallmarks of DRE with the identified upstream regulators offering novel opportunities for drug-target discovery and development.
Improving adolescents’ dietary behavior through teacher-delivered cancer prevention education: A school-based cluster randomized intervention trial in urban Rajasthan
Authors: Mittal Ankit , Rustagi Neeti , Thirunavukkarasu Prasanna , Ghosh Santu , Raghav Pankaja 
Published: June 2023

Abstract
Background
Dietary practices are one of the most common modifiable risk factors for cancers. Foods rich in dietary fibres are considered protective, and fast & junk foods are risk for common cancers. Adolescence period is marked by habit formation and is thus suited for delivering behavioral intervention. Schools offer an optimal setting for planning and executing these interventions to a large number of adolescents.
Objective
To assess the effectiveness of a classroom-based teacher delivered cancer prevention education in improving dietary behaviors among school going urban adolescents.
Methods
A cluster randomized trial was conducted in government secondary and senior secondary schools with schools as clusters. A sample of 1024 students was estimated from 16 schools with 1:1 allocation in control and intervention group. Student’s self-reported dietary behaviors for eating healthy and avoiding unhealthy foods, and their determinants as per theory of planned behavior framework were recorded. Two teachers from each of 8 intervention schools were trained to deliver cancer prevention education to students within regular school curriculum with focus on dietary behaviors.
Results
A total of 1096 students from 8 intervention and 8 control group schools completed the study. The study recorded significant improvement in scores of students from intervention group (IG) compared to control group (CG) for their attitude, subjective norms, perceived behavioral control and intention towards consuming healthy and avoiding unhealthy foods. The intervention was found effective in significantly improving the proportion of students for limiting fried food, fast food, packed food and sugar sweetened beverages (OR:1.65, 95%CI:1.10,1.47, p:0.015), and consuming fruits and vegetables daily (OR:1.72, 95%CI:1.19,2.50, p:0.004).
Conclusion
Classroom-based cancer prevention education delivered through teachers during regular working hours is effective in improving dietary behaviors and its determinants among adolescent students. Thus, we recommend integrating a section focusing on role of diet towards cancer prevention and other life-style diseases in existing school curriculum.
Trial Registration:
The trial was registered under Clinical Trial Registry-India with registration number CTRI/2018/12/016586.