bluuebunny/crossref_metadata_2025_split huggingface dataset:
THE EFFICACY OF CT-GUIDED PERCUTANEOUS CORDOTOMY ON INTRACTABLE PAIN IN PATIENTS WITH LUNG CANCER
Authors: EGE Ferhat , AKBAS Mert , DAĞISTAN Gözde 
Published: September 2023

ABSTRACT

Aim
This study was carried out to evaluate the efficacy of CT-guided percutaneous cordotomy and postoperative complications in the treatment of intractable pain associated with lung cancer.

Material &Method
Computed tomography (CT) guided-cordotomy was performed on 10 lung cancer patients unresponsive to medical and interventional pain management methods.

Results
The mean pretreatment and post treatment visual analogue scale (VAS) scores of the patients were determined as 10 ± 0.0001 and 1.00 ± 0.67, respectively. Additionally, the mean pretreatment and posttreatment Karnofsky Performance Scale (KPS) scores of the patients were calculated as 40± 9.42 and 73±10.59, respectively. Accordingly, there was a statistically significant difference between the pretreatment and posttreatment VAS and KPS scores. Furthermore, the mean pretreatment and posttreatment morphine equivalent dose of the patients were found as 860.2±199.8 mg and 220.7±69.08 mg, respectively.

Conclusion
The findings of this study suggest that cordotomy is a valuable treatment option for intractable pain problems in patients suffering from lung cancer.
Yaşa Bağlı Makula Dejenerasyonu İle Serum Anneksin A3 (ANXA3) Düzeylerinin İlişkisi
Authors: ÖZTÜRK Alpaslan , GÜL Mehmet Ali , AĞBEKTAŞ Tuğba , ZONTUL Cemile , ÇİFTÇİ Cem Hakan , TAŞ Ayça , YALINBAŞ YETER Duygu , SİLİĞ Yavuz 
Published: September 2023

Giriş: Yaşa bağlı maküler dejenerasyonu gelişmiş toplumlarda ileri derecede görme kaybının en sık nedenidir. ANXA3, hücre sinyal yolakları, hücre profilerasyonu, invazyon, metastaz ve hücre apoptozuna etki ederek tümör gelişimine katkı sağlamaktadır.
Yöntemler: Bu çalışma yaş tip YBMD tanısı alan 39 hasta, aynı zaman diliminde kuru tip YBMD tanısı alan 39 olmak üzere toplam 78 hasta ve daha önce herhangi bir maküler dejenerasyon tanısı almamış sağlıklı 39 kontrol grubundan oluşturuldu. ANXA3 düzeyleri enzim bağlantılı immünosorbent tahlil (ELISA) yöntemi ile tespit edildi.
Bulgular: Bu çalışmada serum ANXA3 düzeyleri kontrol grubuna göre kuru tip YBMD hastalığında anlamlı bir farklılık tespit edildi (p
Experience of 2<sup>nd</sup> line therapy with eltrombopag in patients with immune thrombocytopenia
Authors: Zakharov S. G. , Mitina T. A. , Vardanyan R. V. , Tekeeva Z. R. , Kontievskiy I. N. , Chuksina Yu. Yu. , Zakharova A. V. 
Published: September 2023

Background. Immune thrombocytopenia (ITP), or idiopathic thrombocytopenic purpura, is a hematological autoimmune disease characterized by bleeding and an isolated decrease in platelet count <100 × 109 / l. The decision to start treatment for ITP depends on several factors. The ITP treatment strategy is based on the clinical symptoms, with a focus on reducing the risk of severe bleeding and increasing platelet counts. Aim. To evaluate the efficacy of 2nd line therapy with the thrombopoietin receptor agonist eltrombopag in patients with ITP. Materials and methods. 490 patients with ITP are under observation at the center for orphan diseases of M. F. Vladimirskiy Moscow Regional Research Clinical Institute. The present study included 186 patients with primary ITP after 1st line glucocorticosteroid therapy. eltrombopag, a thrombopoietin receptor agonist, was prescribed as the 2nd line of therapy. Results. The median platelet count prior to eltrombopag therapy in all patients was 27.5 × 109 / l. after eltrombopag therapy, a significant (by 490 %) increase in platelet levels (median 135 × 109 / l) and a complete response according to clinical recommendations were noted. Conclusion. Glucocorticosteroids (prednisolone, dexamethasone) remain the drugs of choice for the 1st line of therapy. Treatment with drugs of this group in most cases allows achieving an optimal platelet level and preventing bleeding. In case of inefficiency, intolerance, occurrence of side effects, the appointment of thrombopoietin receptor agonists eltrombopag or romiplostim is recommended. therapy with eltrombopag at a dose of 50 mg daily for several weeks has been able to achieve an increase in platelet levels, correct hemorrhagic syndrome, reduce the number of side effects during first-line glucocorticosteroid therapy, and improve the patient’s quality of life.
Simulating Strong Ground Motion from the Great 1923 Kanto Earthquake in the Tokyo Metropolitan Area Based on Source Model Derived from Seismic Intensity Data
Authors: Suzuki Fumino , Kato Kenichi , Watanabe Tetsushi , Kanda Katsuhisa , Tomozawa Yusuke 
Published: September 2023

ABSTRACT
This study simulates strong ground motions in the Tokyo metropolitan area during the 1923 Kanto earthquake using the stochastic Green’s function method. Source characteristics were modeled using seismic intensity inversion analysis, and path and site characteristics were modeled using inhomogeneous attenuation structure and empirical amplification factors. The results of these simulations were consistent with seismic intensities estimated based on the collapse rate of wooden houses. The distribution of pseudovelocity response spectra averaged at periods of 1–2 s was large: ∼200 cm/s in southern Kanagawa and southern Chiba prefectures, ∼100–200 cm/s in eastern Tokyo, and ∼50–100 cm/s in eastern Saitama prefecture despite its distance from strong-motion generation areas (SMGAs). The simulation results were regressed on site characteristics and fault distance, and the residuals were interpolated using the Kriging method to estimate detailed maps of seismic intensity and response spectra on an ∼250 m mesh reflecting site-specific characteristics. The following conclusions can be made: (1) all SMGAs, other than those in northern Tokyo Bay, were located near large slip areas based on coseismic geodetic and seismic waveform data. Although the SMGAs in the northern part of Tokyo Bay exerted little influence on the southern part of the Kanto region, their consideration was required to reproduce the seismic intensity at the northwest Tokyo and Saitama; (2) intense strong motion in central Tokyo occurred at the back marsh, delta, coastal lowlands, and filled lands, whereas low levels of strong motion were determined at terraces covered with volcanic ash soil. Combined with building distribution, this indicates areas of high seismic risk; (3) the seismic intensity and response spectra in the Tokyo metropolitan area obtained through this simulation were larger than those obtained from seismic records of the 2011 Tohoku earthquake—the most recent megathrust earthquake.
Using of the Politeness Principle in Dissertation Writing: Focus on the English Department of the Teacher Training College of Mbujimayi
Authors: KABUYI KAHAMBA Patrick 
Published: September 2023

Communication is oral, written, etc. When we communicate through writing or any other way, we should pay attention to our addressee or interlocutor so as to avoid hurting the latter, be it in speaking or writing. I was shocked to notice students are not prudent to the way they are addressing to others: teachers, pupils, inspectors and so on. The speaker or writer of any language should respect some established principles of that language i.e. the communication in any language is interesting when it implies the use and respect of that languages’ politeness rules.
I have selected twenty dissertations from the department of English of the Teacher Training College of Mbujimayi, DRC. These dissertations are from different domains: grammar, theoretical linguistics, and literature or applied linguistics. I have been focused on dissertations sections such as: Problem definition, choice and interest of the work, aims and purposes of the study, and further studies. I have noticed that the politeness maxims are more violated in dissertations than they are observed. To avoid violating more the politeness principle (PP) in both speaking and writing, I have suggested that the PP get taught to students in conversations and research methodology courses. Students should be familiarized to practicing the PP maxims in classroom reports and debates, in essay writing, in letters, etc.
The Influence of Locus of Control and Self-Efficacy on the Performance of Civil Servants Through Job Satisfaction in the Detachment Work Unit of the Navy Staff and Command School Detachment (DENMA SESKOAL)
Authors: Sulastri  , Suharto  , Subagja Iwan Kurniawan 
Published: September 2023

This study aims to: 1) test and analyze the locus of control effect on job satisfaction of Civil Servants Denma Seskoal, 2) test and analyze the self-efficacy effect on job satisfaction of Civil Servants Denma Seskoal, 3) test and analyze the locus of control effect on Civil Servants Denma Seskoal, 4) test and analyze self-efficacy affect the performance of Civil Servants Denma Seskoal, 5) test and analyze job satisfaction affect the performance of Civil Servants Denma Seskoal, 6) test and analyze locus of control effect on performance through job satisfaction Civil Servants Denma Seskoal, 7) test and analyze self-efficacy effect on performance through job satisfaction Civil Servants Denma Seskoal.
The results of the study show that: 1) Locus of Control has a significant effect on the job satisfaction of Denma Seskoal Civil Servants. 2) Self-efficacy has a significant effect on the job satisfaction of Denma Seskoal Civil Servants. 3) Locus of Control has a significant effect on the performance of Denma Seskoal Civil Servants. 4) Self-efficacy has a significant effect on the performance of Denma Seskoal Civil Servants. 5) Job satisfaction has a significant effect on the performance of Denma Seskoal Civil Servants. 6) Testing the sixth hypothesis that Locus of Control has no significant effect on employee performance through job satisfaction of Civil Servants Denma Seskoal 7) Testing the seventh hypothesis that self-efficacy has no significant effect on employee performance through job satisfaction of Civil Servants Denma Seskoa. The variable of job satisfaction is not able to be an intermediary variable between the influence of Locus of Control and self-efficacy on the performance of Denma Seskoal Civil Servants.
Bilinç kaybı yaşayan hastalarda epileptik nöbet ve senkop ayırıcı tanısında kullanılabilecek belirteçler
Authors: SARICA  DAROL Elif , DALKILIÇ Sule 
Published: September 2023

Amaç: Bilinç kaybı, senkop ve epileptik nöbetlerin ortak belirtisidir. Çalışmamızda acil servise bilinç kaybı ile başvuran hastalarda senkop ve epileptik nöbet ayırıcı tanısı için kullanılabilecek klinik ve biyokimyasal biyobelirteçleri belirlemek amaçlanmıştır.
Gereç ve Yöntemler: Hastanemiz acil servisine üç ay boyunca bilinç kaybı şikâyeti ile başvuran hastaların dosyaları ve laboratuvar incelemeleri (laktat, hemoglobin, nötrofil, lenfosit) sonuçları tarandı, demografik özellikleri ve eşlik eden hastalıkları kaydedildi. Elde edilen veriler istatistiksel analizinde SofaStat (Auckland, New Zealand) programı kullanıldı.
Bulgular: Epileptik nöbet nedeniyle başvuran hastalar, senkop nedeniyle başvuranlara kıyasla daha genç hastalardı ancak cinsiyet dağılımı birbirine benzerdi. Senkop ile başvuranlarda diyabet ve hipertansiyon öyküsü daha fazlaydı. İlk kez başvuranlara kıyasla daha önce benzer nöbet yaşayanların epilepsi olma olasılığı daha fazlaydı. Epileptik nöbet ile başvuranlarda, epizot sonrasında konfüzyon öyküsü senkop ile başvuranlardan daha fazlaydı. Epileptik nöbet nedeniyle başvuranların serum laktat düzeyi ortancası (3,3 U/L), senkop nedeniyle başvuranlara (2,3 U/L) kıyasla anlamlı düzeyde daha yüksekti (p=0,002). Serum laktat değerleri analiz edildiğinde, epilepsi ve senkop hastalarını ayırt etmek için en iyi eşik değer 2,5 U/L idi. Bu eşik değerin tanısal doğruluk oranı % 60,5 iken, sensitivitesi %60,2 ve spesifisitesi %62,3 idi. Kadınların hemoglobin ve hematokrit değerlerinin ortancası erkeklere kıyasla anlamlı düzeyde daha düşüktü.
Sonuç: Çalışmamızın sonuçları, serum laktat düzeylerinin epileptik nöbet nedeniyle başvuran hastaları senkop nedeniyle başvuranlardan ayırt etmede önemli bir biyobelirteç olduğunu göstermektedir. Serum laktat değeri özellikle hasta ve hasta yakınlarının epizodu tarifleyemediği durumlarda değerli bilgiler sunabilir.
Spor Bilimleri Fakültesi Öğrencilerinde Zaman Yönetiminin Genel Erteleme ve Sosyal Medya Bağımlılığına Etkisi
Authors: ÇİFTÇİ İsa , ÖZAVCİ Ramazan 
Published: September 2023

Amaç: Bu araştırmanın amacı, spor bilimleri fakültesi öğrencilerinin zaman yönetiminin genel erteleme davranışı ve sosyal medya bağımlılığına etkisinin incelenmesidir.
Yöntem: Araştırmanın örneklemini Bingöl Üniversitesi Spor Bilimleri Fakültesinde okuyan 194 kadın ve 198 erkek olmak üzere toplam 392 üniversite öğrencisi oluşturmaktadır. Araştırmada kişisel bilgi formunun yanı sıra “Zaman Yönetimi Ölçeği”, Genel Erteleme Ölçeği” ve “Sosyal Medya Bağımlılığı Ölçeği” kullanılmıştır. Elde edilen verilerin normalliği test edildikten sonra güvenirlik sonuçları incelenmiştir. Bu çalışmanın analizlerinde, değişkenler arasındaki ilişkiyi belirlemek için korelasyon analizi kullanılmış, ayrıca bağımsız değişkenin bağımlı değişken üzerindeki etkisini değerlendirmek amacıyla regresyon analizi uygulanmıştır.
Bulgular: Araştırma bulguları öğrencilerin zaman yönetimleri ile sosyal medya bağımlılığı ve erteleme davranışları arasında istatistiksel olarak anlamlı ilişkiler saptanmıştır. Buna göre, zaman planı ile sosyal medya bağımlılığı (r: -0,170; p
Implikasi Pengaturan Pengeras Suara (Toa) Terhadap Hukum Masyarakat Yang Berbasis Agama
Authors: Darmawan  , Achmad Hidayat  
Published: September 2023

Pengaturan tentang pengguunaan pengeras suara menjadi polemik di masyarakat, utamanya masyarakat Indonesia yang beragama Islam, menjadikan pengeras suara sebagai salah satu hal yang wajib ada dalam setiap agenda peribadatan seperti adzan, sholawat, doa, dzikir dana lain sebagainya. Yang mana nilai-nilai keberagamaan tersebut sudah menjadi sesuatu yang lumrah dan bisa diterima oleh masyarakat secara komunal. Meskipun tidak secara implisit negara mengakomodir nilai-nilai Islam dalam pembentukan peraturan perundang-undangan. Dengan mayoritas muslim terbesar sudah menjadi sebuah keharusan bahwa hukum positif banyak dihiasi oleh nilai-nilai Islam. nilai tersebut telah termanifestasi dalam bentuk norma dan kebiasan dalam masyarakat. Sesuai dengan teori hierarki maka hukum positif yang sifatnya praktik harus berangkat dari norma-norma yang ada dalam masyarakat, termasuk orma yang bernuansa spiritual kegamaan.
Problematikan diatas kemudian dianalisa dengan mengunakan jenis penelitian hukum normatif, yaitu penelitain yang berbasis pada kajian Pustaka, berdasarkan peraturan perundang-undangan yang berlaku, dalam hal ini adalah Surat Edaran Menteri Agama Nomor 05/2022 2022 tentang Pedoman Penggunaan Pengeras Suara di Masjid dan Mushola. Dengan menggunakan pendekatan statue approach (pendekatan perundang-undangan), dan conceptual approach (pendekata konsep). Dari penelitain ini dihasilakn sebuah kesimpulan bahwa pengaturan menganai pengeras suara selain di dasarkan pada syariat Islam (al-Quran dan Sunnah), harus memperhatikan juga norma-norma yang hidup dalam masyarakat (living law) yang juga dipengaruhi oleh berbagai aspek ekonomi, politik, kultur dan agama.
Determinants of Stunting in Toddlers In Gatak Subdistrict, Sukoharjo Regency
Authors: Johar Syefira Ayudia , Sartika Iik 
Published: September 2023

<span>Indonesia faces nutritional problems that have an impact on the quality of human resources. One of the nutritional problems is the incidence of stunting experienced by more than half of stunting toddlers in the world who come from ASIA (55%). The highest number of stunting cases is based on e-PPGBM data for 2020-2021 in Sukoharjo Regency in Gatak District. In Gatak District, from 2020 to 2021, there has been an increase in stunting cases in toddlers. In 2020 in Gatak District, the number of stunted toddlers was 414 toddlers while in 2021 the number of stunted toddlers increased to 463 toddlers. </span><span>This research is a quantitative research with a cross-sectional approach. The bound variables in this study are the incidence of stunting in toddlers, while the free variables in the study are maternal knowledge about nutrition, exclusive breastfeeding status, parental income, BBLR history and child care. The research sample was taken with a sampling quota with a total sample of 96 respondents who were toddlers in Gatak District, Sukoharjo Regency in 2021. The analysis used by researchers to determine the relationship of each variable using chi square analysis. The value of P is said to be related if the Value of P is &lt;0.05. Based on the frequency distribution is mostly on productive age, higher education level, mostly employed, and income level is largely less than the UMR. There is a significant relationship between maternal knowledge, exclusive breastfeeding status, BBLR history and parenting with stunting events (p value = 0.000 &lt; 0.05), while parental income has nothing to do with stunting events (p value = 0.067 &gt; 0.05).</span>
The significant difference in compensatory mechanism of sagittal spinopelvis between patients with lumbar disc herniation and patients with spondylolisthesis
Authors: Chen Ying , Yang Zong , Liang Jie , Ru Neng , Wu Weifei 
Published: September 2023

Abstract
Background: Sagittal spinopelvis plays an important role in occurrence and development in spinal disorders, no study was focused on the differences of spinopelvic alignment between patients with LDH and patients.
Objective: to study differences of spinopelvic alignment and to analyze differences of correlation between sagittal alignment parameters among patients with lumbar disc herniation (LDH), spondylolisthesis (SPL) and normal population.
Methods: Standard up-standing antero-posterior and lateral X-ray of the whole spine were preformed in all subjects. Evidence of LDH was confirmed by CT or MRI. SPL was diagnosed by X-ray or MRI. The parameters were measured including TK, LL, PI, SS, PT and SVA in lateral radiography.
Results: 60 patients with LDH, 62 patients with SPL and 57 normal were included. Significant differences for the SS, TK, LL and SVA (P <0.05) was found among three groups. PI of SPL patients was the highest among the three groups (P <0.05). PT of both SPL patients and LDH patients were significant higher than controls’ (P <0.05). LL of LDH patients was the lowest among the three groups (P <0.05). PI was less correlated with LL (P <0.05) in patients with LDH and SPL. PT was more strongly negative correlated with SS, LL and TK in LDH group (P <0.05). SS was more strongly positive correlated with TK (P <0.05), and SS and LL were more strongly negative correlated with SVA (P <0.05) in LDH patients.
Conclusions: the present results indicated a disharmonious spinopelvic relationship and exhibited different compensatory models of spine to adapt changes in spinal alignment in LDH patients and SPL patients.
Variations in time to breast cancer treatment initiation and survival across ethnoracial groups: a DAG-based protocol for a systematic review and meta-analysis
Authors: Hesari Parisa M. , Lizotte Daniel J. , Bauer Greta R. 
Published: September 2023

Abstract

Background
Racial disparities in access to care are a known driver of differential health outcomes. There is a need to synthesize knowledge on the impact and mechanisms of ethnoracial variations in initiation of breast cancer treatment. The aim of the study described in this protocol is to systematically review the existing evidence on ethnoracial disparities in initiation of breast cancer treatments and their impact on patients’ survival in the United States.
Methods
A comprehensive systematic search of databases including PubMed, Ovid, Web of science, and the Cochran library will be performed. An extra search filtered on the title will be carried out on Google Scholar. Two main keywords, ‘breast cancer’ and ‘time to treatment,’ will be used in search strings. The review process will follow Preferred Reporting Items for Systematic Review and the Meta-Analysis Protocols (PRISMA-P) guidelines and will include studies of cohorts of female breast cancer patients who were diagnosed with stage I-III in the US. The Risk Of Bias In Non-randomised Studies – of Interventions (ROBINS-I) tool will be applied for bias assessment, and only studies with low or moderate risk of bias will be included. A modified checklist for applying the Evidence synthesis for constructing directed acyclic graphs (ESC-DAGs) method is developed to describe the causal relationships between ethnoracial group membership, other study variables, delays to treatment, and survival.
Discussion
This systematic review will summarize the impact of racial disparity on breast cancer survival considering delays in receiving treatments as a mediator. Future directions will be identified to address existing gaps potentially relevant to creating equity for racial and ethnic minority groups. The results can help health authorities to develop approaches for addressing racial disparities in access to breast cancer treatment at the population level.
Zinc Oxide Nanoparticles (ZnO NPs) Treated Two Types of Osteosarcoma Cell Lines for Identifying Differentially Expressed Genes
Authors: Guo Xiangfei , Wang Linbang , Yang Honghao , He Guanping 
Published: September 2023

Abstract

Osteosarcoma (OS) primarily affects in adolescents, and is more prevalent in males than females. It is characteristics by local invasive growth and early pulmonary metastases. Nanoparticles (NPs) have emerged as a promising alternative to traditional chemotherapeutic drugs due to their high selectivity and effectiveness. Previous studies have demonstrated the potential of zinc oxide nanoparticles (ZnO NPs) as a treatment for various tumors except OS. In this study, we use RNA-seq analysis to investigate the underlying biological mechanism involved in the process of ZnO NPs-treated different types of OS cell lines. We identified 928 differentially expressed genes (DEGs) in both 143B and MG-63 cells, and we validated the expression of the eight most significant DEGs using RT-qPCR. Gene Ontology (GO) analysis displayed regulation of transcription factor on nucleic acid binding in molecular function term, and extracellular space in cellular components term in both OS cell lines. Additionally, Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis revealed the co-enrichment of the MAPK, Toll-like receptor, and NF-κB pathways in both OS cell lines. Protein-protein interaction (PPI) analysis highlighted the involvement of HMOX1, MAFB, CXCL10, and CXCL11 in various biological processes in OS cells treated with ZnO NPs. Furthermore, we confirmed the key protein molecules in the differential signaling pathways of both OS cell lines using Western Blot (WB). Our findings shed light on the potential antitumor mechanisms and exploitable bioeffects of ZnO NPs in the treatment of OS. This study provides more targets and possible mechanisms for the treatment of ZnO NPs, as well as more theoretical basis for the treatment of OS.