bluuebunny/crossref_metadata_2025_split huggingface dataset:
Involving people with a lived experience when developing a proposal for Health Technology Assessment research of nonsurgical treatments for pelvic organ prolapse: Process and reflections
Authors: Johnson Eugenie Evelynne , Lally Joanne , Farnworth Allison , Pearson Fiona 
Published: February 2023

AbstractIntroductionPatient and public involvement (PPI) is an expectation when conducting research, including Health Technology Assessment (HTA), but practical guidance for those wishing to embed PPI into the grant application process is not always easily accessible. We wanted to ensure that PPI was central when preparing a proposal for an investigator‐led evidence synthesis HTA investigating nonsurgical interventions for pelvic organ prolapse (POP) in women. Here, we describe our methods.MethodsWe recruited two patient co‐applicants separately through an open process to help ensure that patient voice was present within our proposal's management and direction. We invited co‐applicants to attend research team meetings and comment on the full proposal. We designed, recruited to and facilitated a scoping workshop, as well as undertook its subsequent evaluation. The insight shared within the workshop for patients with a lived experience of POP, including our patient co‐applicants, helped us develop the scope and rationale behind our HTA proposal. We particularly considered the interventions to include within the evidence synthesis. We also considered the outcome measures for both the evidence synthesis and economic evaluation. We elicited ideas about where and how results could be disseminated. Feedback suggested the workshop was as valuable for the attendees as it was for the researchers, making them feel valued and listened to. The time spent by researchers working on the activity was substantial and not directly funded but a necessary and valuable activity in developing our potential HTA. Our work was informed using the UK Standards for Public Involvement and the Authors and Consumers Together Impacting on eVidencE (ACTIVE) framework.ConclusionsPPI can be enormously valuable in both developing and strengthening research proposals. However, further guidance is needed to help researchers recognise the level and type of involvement to use at this early stage, particularly given the large time investment needed to embed meaningful PPI.Patient and Public ContributionWomen with a lived experience of POP were involved at every stage of the grant application process; their involvement is documented in full throughout this work.
HISTORY MAKING AND ETHICS—AN INTEGRAL RELATIONSHIP?
Authors: Berger Stefan 
Published: February 2023

ABSTRACTIn this review essay, I examine the arguments made by Marnie Hughes‐Warrington, with Anne Martin, in Big and Little Histories: Sizing Up Ethics in Historiography. While I find much to praise in this history, I also ask critical questions about the impact of non‐Western ethics on historical writing, the role of ethics in historical writing generally, the need to further investigate the everyday lifeworlds of history makers in order to fully understand their ethical dispositions, and the relationship between the ethics of history making and engaged forms of historical writing. I conclude this review essay by offering some reflections on the interrelationship between history and memory and the ethics involved in both.
Illicit activity and scarce natural resources in the supply chain: A literature review, framework, and research agenda
Authors: Hilend Rowan , Bell John E. , Griffis Stanley E. , Macdonald John R. 
Published: February 2023

AbstractThis article reviews extant multidisciplinary literature to uncover existing themes and directions in the knowledge of the overlap between natural resource scarcity and illicit supply chain activity. In doing so, the authors present a novel review of this nascent, complex, and multidisciplinary research area. This review has uncovered 127 articles that have not been synthesized or organized in a meaningful way with the supply chain literature. It extracts insights and develops a comprehensive process framework encompassing the following: (a) antecedents associated with natural resource extraction, which foments the opportunity for illicit activity to thrive; (b) resulting economic, social, and environmental outcomes from illicit activity as it relates to natural resource extraction; and (c) potential moderating processes, which either enable or inhibit illicit activity to occur, including firm‐level tactics that businesses can employ to counteract illicit activity throughout the supply chain and to promote sustainable long‐term operations. An extensive agenda is presented suggesting future research paths, methodologies, theories, and potential contributions.
Thermophysical properties of parchment coffee: New Colombian varieties
Authors: Duque‐Dussán Eduardo , Sanz‐Uribe Juan R. , Dussán‐Lubert Carmen , Banout Jan 
Published: February 2023

AbstractThe thermophysical properties of coffee have a special partaking during the drying process since a material‐depending heat and mass transfer occurs between the bean and the drying air. Conditional to the thermophysical properties of the parchment coffee, the drying can be more or less efficient, affecting the final quality and seed safety. Several coffee varieties have been studied; however, the National Coffee Research Center of Colombia has developed new highly productive coffee varieties resistant to different diseases: Cenicafé 1 and Castillo®. Nevertheless, the thermophysical properties of these specific varieties were not yet investigated; moreover, the availability of information related to these properties of different coffee varieties in the literature is relatively scarce. Thus, this study targeted to determine the parchment coffee thermophysical properties of these new varieties at five different moisture contents % (wb): 53%, 42%, 32%, 22% and 11%, using optimized techniques and methods to ensure high accuracy and exactness. It was found that the new varieties have larger, heavier, and denser beans; it was also seen that the bulk thermal conductivity and the bulk‐specific heat are higher in these varieties than in the older ones. It was also revealed that the length, width, thickness, and surface area did not change as the moisture was removed, whereas the bulk density, kernel density, mass, bulk‐specific heat, and bulk thermal conductivity decreased as the moisture was reduced. Displaying better thermophysical properties will improve the drying and roasting processes; hence, a better final product can be expected from these varieties.Practical applicationsKnowing the thermal and physical properties of these new varieties will allow the growers and coffee processing facilities to predict, simulate and control different post‐harvesting processes such as pulping, fermentation, drying, storing, and roasting. Also, the already developed mathematical models to estimate coffee drying times can be updated, improving the accuracy of the predictions, bed porosities, mass, and heat transfer in order to safeguard the innocuousness of the product.
The challenges and opportunities of open‐access microscopy facilities
Authors: Cartwright Heather N. , Hobson Chad M. , Chew Teng‐Leong , Reiche Michael A. , Aaron Jesse S. 
Published: February 2023

AbstractMicroscopy core facilities are increasingly utilised research resources, but they are generally only available to users within the host institution. Such localised access misses an opportunity to facilitate research across a broader user base. Here, we present the model of an open‐access microscopy facility, using the Advanced Imaging Center (AIC) at Howard Hughes Medical Institute Janelia Research Campus as an example. The AIC has pioneered a model whereby advanced microscopy technologies and expertise are made accessible to researchers on a global scale. We detail our experiences in addressing the considerable challenges associated with this model for those who may be interested in launching an open‐access imaging facility. Importantly, we focus on how this model can empower researchers, particularly those from resource‐constrained settings.
The relationship between serum neurofilament light chain and glial fibrillary acidic protein with the REM sleep behavior disorder subtype of Parkinson's disease
Authors: Teng Xing , Mao Shuai , Wu Han , Shao Qiuyue , Zu Jie , Zhang Wei , Zhou Su , Zhang Tao , Zhu Jienan , Cui Guiyun , Xu Chuanying 
Published: February 2023

AbstractStudies have shown that rapid eye movement (REM) sleep behavior disorder (RBD) is a subtype of Parkinson's disease (PD) characterized by severe cognitive impairment and rapid disease progression. However, reliable biological markers are lacking presently. Neurofilament light chain (NFL) and glial fibrillary acidic protein (GFAP) have been widely studied as biomarkers of cognition impairment. This study aimed to find biomarkers for the RBD subtype of PD by investigating the possible relationship between serum NFL, GFAP levels, and the RBD subtype. A total of 109 PD patients and 37 healthy controls (HCs) were included, and their clinical characteristics were evaluated. PD patients were divided into two groups based on whether they had probable RBD or not. Serum NFL and GFAP levels were measured using the ultrasensitive single molecule array (Simoa) platform. The obtained data were statistically analyzed using SPSS 25.0 (IBM, Chicago, IL, USA). NFL and GFAP in the PD‐RBD group were elevated compared with the PD‐nRBD and control groups. Moreover, serum NFL and GFAP levels positively correlated with RBD. The combination of NFL and GFAP showed good performance in identifying PD‐RBD patients from PD‐nRBD. After considering potential confounding factors such as age, and disease duration, serum NFL and GFAP emerged as independent risk factors for RBD. Serum NFL and GFAP were related to RBD in PD patients. Concludingly, serum NFL and GFAP might serve as promising biomarkers for the RBD subtype of PD.image
Controlled ovarian stimulation for endometriosis patients with ultra‐long GnRH‐agonist or GnRH‐antagonist protocols: A retrospective study by propensity score matching
Authors: Chen Qingfen , Du Shengrong , Lin Yunhong , Zheng Beihong 
Published: February 2023

AbstractObjectivesAlthough in vitro fertilization with embryo transfer is the most effective treatment for infertile patients with endometriosis, ovarian stimulation protocols are controversial.Study DesignWe recruited 639 patients with endometriosis from January 2016 to June 2020; 111 and 528 patients were treated with the gonadotropin‐releasing hormone (GnRH) antagonist and ultra‐long GnRH agonist protocols, respectively. Potential baseline differences between the regimens were adjusted by propensity score matching. Clinical and laboratory data, including the cumulative clinical pregnancy rate (CCPR) and cumulative live birth rate (CLBR), were compared.ResultsOvulation induction required significantly longer use of gonadotropins in the GnRH agonist group. However, the GnRH agonist group had a lower starting dose of gonadotropin (all p < 0.05). Furthermore, significantly lower clinical pregnancy, implantation, and live birth rates were observed in the GnRH antagonist group receiving fresh assisted reproductive technology cycles (all p < 0.05); however, pregnancy outcomes using the subsequent freeze–thaw cycles for the same oocyte retrieval were not significantly different. CCPR and CLBR for the oocyte retrieval cycles of the antagonist and ultra‐long agonist protocols were similar. The ultra‐long agonist protocol resulted in more favorable implantation of fresh embryos and improved clinical outcomes of the fresh cycle.ConclusionsThis novel strategy could be appropriate for endometriosis patients who are temporarily unsuitable for fresh embryo transfer. The GnRH antagonist protocol can be combined with the whole embryo freezing strategy to achieve CCPR and CLBR similar to the ultra‐long agonist regimen, thus simultaneously avoiding the long pre‐treatment duration of GnRH agonists during the ultra‐long agonist protocol.
The lay of the land: Associations between environmental features and personality
Authors: Militaru Ioana E. , Serapio‐García Gregory , Ebert Tobias , Kong Wenyuan , Gosling Samuel D. , Potter Jeff , Rentfrow Peter J. , Götz Friedrich M. 
Published: February 2023

AbstractObjectivePersonality traits cluster across countries, regions, cities, and neighborhoods. What drives the formation of these clusters? Ecological theory suggests that physical locations shape humans' patterns of behaviors and psychological characteristics. Based on this theory, we examined whether and how differential land‐cover relates to individual personality.MethodWe followed a preregistered three‐pronged analysis approach to investigate the associations between personality (N = 2,690,878) and land‐cover across the United States. We used eleven land‐cover categories to classify landscapes and tested their association with personality against broad physical and socioeconomic factors.ResultsUrban areas were positively associated with openness to experience and negatively associated with conscientiousness. Coastal areas were positively associated with openness to experience and neuroticism but negatively associated with agreeableness and conscientiousness. Cultivated areas were negatively associated with openness. Landscapes at the periphery of human activity, such as shrubs, bare lands, or permanent snows, were not reliably associated with personality traits.ConclusionsBivariate correlations, multilevel, and random forest models uncovered robust associations between landscapes and personality traits. These findings align with ecological theory suggesting that an individual's environment contributes to their behaviors, thoughts, and feelings.
Quarantined judicial expansion: The environmental legal entrepreneurship of Chinese courts, procuratorates, and NGOs
Authors: Wang Yueduan , Xia Ying 
Published: February 2023

AbstractAlthough judicial empowerment has become increasingly common worldwide, the expansion of judicial powers in authoritarian countries faces persistent obstacles, such as institutional dependence, lack of political clout, and the repression of civil society. Through empirically examining three cases of environmental legal entrepreneurship under China's new public interest litigation (PIL) system, this study aims to reevaluate the patterns and limits of judicial expansion under authoritarianism. It finds that Chinese judges, prosecutors, and NGOs have been able to leverage the PIL system and their respective institutional advantages to substantially expand judicial oversight on eco‐environmental protection. However, the state has established boundaries for such legal entrepreneurship in terms of subject matter, institutional autonomy, and geographic reach, effectively confining them within political spheres considered unthreatening to the regime. Such quarantined judicial expansion shields relevant actors from authoritarian governments' tendency to suppress legal mobilization and thus may be a more viable form of judicial expansion in nondemocratic settings.
Induction of aphid resistance in tobacco by the cucumber mosaic virus CMV∆2b mutant is jasmonate‐dependent
Authors: Arinaitwe Warren , Tungadi Trisna D. , Pate Adrienne E. , Joyce Joshua , Baek Eseul , Murphy Alex M. , Carr John P. 
Published: February 2023

AbstractCucumber mosaic virus (CMV) is vectored by aphids, including Myzus persicae. Tobacco (Nicotiana tabacum ‘Xanthi’) plants infected with a mutant of the Fny strain of CMV (Fny‐CMVΔ2b, which cannot express the CMV 2b protein) exhibit strong resistance against M. persicae, which is manifested by decreased survival and reproduction of aphids confined on the plants. Previously, we found that the Fny‐CMV 1a replication protein elicits aphid resistance in plants infected with Fny‐CMVΔ2b, whereas in plants infected with wild‐type Fny‐CMV this is counteracted by the CMV 2b protein, a counterdefence protein that, among other things, inhibits jasmonic acid (JA)‐dependent immune signalling. We noted that in nontransformed cv. Petit Havana SR1 tobacco plants aphid resistance was not induced by Fny‐CMVΔ2b, suggesting that not all tobacco varieties possess the factor(s) with which the 1a protein interacts. To determine if 1a protein‐induced aphid resistance is JA‐dependent in Xanthi tobacco, transgenic plants were made that expressed an RNA silencing construct to diminish expression of the JA co‐receptor CORONATINE‐INSENSITIVE 1. Fny‐CMVΔ2b did not induce resistance to M. persicae in these transgenic plants. Thus, aphid resistance induction by the 1a protein requires JA‐dependent defensive signalling, which is countered by the CMV 2b protein.
On‐therapy impedance‐pH monitoring can efficiently characterize PPI‐refractory GERD and support treatment escalation
Authors: Frazzoni Marzio , Frazzoni Leonardo , Ribolsi Mentore , Russo Salvatore , Conigliaro Rita , De Bortoli Nicola , Savarino Edoardo 
Published: February 2023

AbstractBackgroundOn‐therapy impedance‐pH monitoring is recommended in patients with documented GERD and PPI‐refractory heartburn in order to establish whether the unremitting symptom is reflux‐related or not.AimsTo define on‐PPI cut‐offs of impedance‐pH metrics allowing proper interpretation of on‐therapy impedance‐pH monitoring.MethodsBlinded expert review of impedance‐pH tracings performed during double‐dosage PPI, prospectively collected from 150 GERD patients with PPI‐refractory heartburn and 45 GERD patients with PPI‐responsive heartburn but persisting extra‐esophageal symptoms. Acid exposure time (AET), number of total refluxes (TRs), post‐reflux swallow‐induced peristaltic wave (PSPW) index, and mean nocturnal baseline impedance (MNBI) were assessed. On‐PPI cut‐offs were defined and evaluated with ROC analysis and the area under curve (AUC).ResultsAll the four impedance‐pH metrics significantly differed between PPI‐refractory and PPI‐responsive heartburn cases. At ROC analysis, AUC was 0.73 for AET, 0.75 for TRs, 0.81 for PSPW index, and 0.71 for MNBI; best cut‐offs were ≥1.7% for AET, ≥45 for TRs, ≤36% for PSPW index, and ≤ 1847 Ω for MNBI; AUC of such cut‐offs was 0.66, 0.71, 0.73, and 0.68, respectively. Analysis of PSPW index and MNBI added to assessment of AET and TRs significantly increased the yield of on‐therapy impedance‐pH monitoring in the PPI‐refractory cohort (97% vs. 83%, p < 0.0001). Notably, suboptimal acid suppression as shown by AET ≥1.7% was detected in 43% of 150 PPI‐refractory cases.ConclusionsWe have defined on‐PPI cut‐offs of impedance‐pH metrics by which comprehensive assessment of impedance‐pH tracings, including analysis of PSPW index and MNBI can efficiently characterize PPI‐refractory GERD and support treatment escalation.
The biological paradigm of psychosis in crisis: A Kuhnian analysis
Authors: Pearson Mark , R. Egglestone Stefan , Winship Gary 
Published: February 2023

AbstractThe philosophy of Thomas Kuhn proposes that scientific progress involves periods of crisis and revolution in which previous paradigms are discarded and replaced. Revolutions in how mental health problems are conceptualised have had a substantial impact on the work of mental health nurses. However, despite numerous revolutions within the field of mental health, the biological paradigm has remained largely dominant within western healthcare, especially in orientating the understanding and treatment of psychosis. This paper utilises concepts drawn from the philosophy of Thomas Kuhn to explore the impact of what Kuhn terms ‘anomalies’ within the dominant biological paradigm: the anomaly of the meaningful utterance, the anomaly of complex aetiology and taxonomy and the anomaly of pharmacological inefficacy in recovery. The paper argues that the biological paradigm for understanding psychosis is in crisis and explores the implications for mental health nursing.
The “humanized” N‐glycosylation pathway in CRISPR/Cas9‐edited Nicotiana benthamiana significantly enhances the immunogenicity of a S/preS1 Hepatitis B Virus antigen and the virus‐neutralizing antibody response in vaccinated mice
Authors: Pantazica Ana‐Maria , van Eerde André , Dobrica Mihaela‐Olivia , Caras Iuliana , Ionescu Irina , Costache Adriana , Tucureanu Catalin , Steen Hege , Lazar Catalin , Heldal Inger , Haugslien Sissel , Onu Adrian , Stavaru Crina , Branza‐Nichita Norica , Liu Clarke Jihong 
Published: February 2023

SummaryThe recent SARS‐CoV‐2 pandemic has taught the world a costly lesson about the devastating consequences of viral disease outbreaks but also, the remarkable impact of vaccination in limiting life and economic losses. Vaccination against human Hepatitis B Virus (HBV), a major human pathogen affecting 290 million people worldwide, remains a key action towards viral hepatitis elimination by 2030. To meet this goal, the development of improved HBV antigens is critical to overcome non‐responsiveness to standard vaccines based on the yeast‐produced, small (S) envelope protein. We have recently shown that combining relevant immunogenic determinants of S and large (L) HBV proteins in chimeric antigens markedly enhances the anti‐HBV immune response. However, the demand for cost‐efficient, high‐quality antigens remains challenging. This issue could be addressed by using plants as versatile and rapidly scalable protein production platforms. Moreover, the recent generation of plants lacking β‐1,2‐xylosyltransferase and α‐1,3‐fucosyltransferase activities (FX‐KO), by CRISPR/Cas9 genome editing, enables production of proteins with “humanized” N‐glycosylation. In this study, we investigated the impact of plant N‐glycosylation on the immunogenic properties of a chimeric HBV S/L vaccine candidate produced in wild‐type and FX‐KO Nicotiana benthamiana. Prevention of β‐1,2‐xylose and α‐1,3‐fucose attachment to the HBV antigen significantly increased the immune response in mice, as compared with the wild‐type plant‐produced counterpart. Notably, the antibodies triggered by the FX‐KO‐made antigen neutralized more efficiently both wild‐type HBV and a clinically relevant vaccine escape mutant. Our study validates in premiere the glyco‐engineered Nicotiana benthamiana as a substantially improved host for plant production of glycoprotein vaccines.