bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of Inequities in Cancer Treatment Delay or Discontinuation Following SARS-CoV-2 Infection
Authors: Llanos Adana A. M. , Ashrafi Adiba , Ghosh Nabarun , Tsui Jennifer , Lin Yong , Fong Angela J. , Ganesan Shridar , Heckman Carolyn J. 
Published: January 2023

ImportanceThere is a disproportionately greater burden of COVID-19 among Hispanic and non-Hispanic Black individuals, who also experience poorer cancer outcomes. Understanding individual-level and area-level factors contributing to inequities at the intersection of COVID-19 and cancer is critical.ObjectiveTo evaluate associations of individual-level and area-level social determinants of health (SDOH) with delayed or discontinued cancer treatment following SARS-CoV-2 infection.Design, Setting, and ParticipantsThis retrospective, registry-based cohort study used data from 4768 patients receiving cancer care who had positive test results for SARS-CoV-2 and were enrolled in the American Society for Clinical Oncology COVID-19 Registry. Data were collected from April 1, 2020, to September 26, 2022.ExposuresRace and ethnicity, sex, age, and area-level SDOH based on zip codes of residence at the time of cancer diagnosis.Main Outcomes and MeasuresDelayed (≥14 days) or discontinued cancer treatment (any cancer treatment, surgery, pharmacotherapy, or radiotherapy) and time (in days) to restart pharmacotherapy.ResultsA total of 4768 patients (2756 women [57.8%]; 1558 [32.7%] aged ≥70 years at diagnosis) were included in the analysis. There were 630 Hispanic (13.2%), 196 non-Hispanic Asian American or Pacific Islander (4.1%), 568 non-Hispanic Black (11.9%), and 3173 non-Hispanic White individuals (66.5%). Compared with non-Hispanic White individuals, Hispanic and non-Hispanic Black individuals were more likely to experience a delay of at least 14 days or discontinuation of any treatment and drug-based treatment; only estimates for non-Hispanic Black individuals were statistically significant, with correction for multiple comparisons (risk ratios [RRs], 1.35 [95% CI, 1.22-1.49] and 1.37 [95% CI, 1.23-1.52], respectively). Area-level SDOH (eg, geography, proportion of residents without health insurance or with only a high school education, lower median household income) were associated with delayed or discontinued treatment. In multivariable Cox proportinal hazards regression models, estimates suggested that Hispanic (hazard ratio [HR], 0.87 [95% CI, 0.71-1.05]), non-Hispanic Asian American or Pacific Islander (HR, 0.79 [95% CI, 0.46-1.35]), and non-Hispanic Black individuals (HR, 0.81 [95% CI, 0.67-0.97]) experienced longer delays to restarting pharmacotherapy compared with non-Hispanic White individuals.Conclusions and RelevanceThe findings of this cohort study suggest that race and ethnicity and area-level SDOH were associated with delayed or discontinued cancer treatment and longer delays to the restart of drug-based therapies following SARS-CoV-2 infection. Such treatment delays could exacerbate persistent cancer survival inequities in the United States.
Proximity proteomics reveals role of Abelson interactor 1 in the regulation of TAK1/RIPK1 signaling
Authors: Petersen Max , Chorzalska Anna , Pardo Makayla , Rodriguez Anaelena , Morgan John , Ahsan Nagib , Zhao Ting C. , Liang Olin , Kotula Leszek , Bertone Paul , Gruppuso Philip A. , Dubielecka Patrycja M. 
Published: January 2023

Dysregulation of the adaptor protein Abelson interactor 1 (ABI1) is linked to malignant transformation. To interrogate the role of ABI1 in cancer development, we mapped the ABI1 interactome using proximity‐dependent labeling (PDL) with biotin followed by mass spectrometry. Using a novel PDL data filtering strategy, considering both peptide spectral matches and peak areas of detected peptides, we identified 212 ABI1 proximal interactors. These included WAVE2 complex components such as CYFIP1, NCKAP1, or WASF1, confirming the known role of ABI1 in the regulation of actin‐polymerization‐dependent processes. We also identified proteins associated with the TAK1‐IKK pathway, including TAK1, TAB2, and RIPK1, denoting a newly identified function of ABI1 in TAK1‐NF‐κB inflammatory signaling. Functional assays using TNFα‐stimulated, ABI1‐overexpressing or ABI1‐deficient cells showed effects on the TAK1‐NF‐kB pathway‐dependent signaling to RIPK1, with ABI1‐knockout cells being less susceptible to TNFα‐induced, RIPK1‐mediated, TAK1‐dependent apoptosis. In sum, our PDL‐based strategy enabled mapping of the ABI1 proximal interactome, thus revealing a previously unknown role of this adaptor protein in TAK1/RIPK1‐based regulation of cell death and survival.
Zonotopic recursive least‐squares parameter estimation: Application to fault detection
Authors: Samada Sergio E. , Puig Vicenç , Nejjari Fatiha 
Published: January 2023

SummaryThe uncertain parameters estimation problem for linear discrete‐time systems modeled in regression form and assuming an unknown but bounded description of the noise, is the main subject of this work. Particularly, zonotopic sets for bounding the parametric uncertainty are considered. Then, a zonotopic recursive least‐squares (ZRLS) estimator is proposed and compared with its stochastic counterpart (RLS), as well as with the set‐membership (SM) approach. Likewise, the parameter estimation problem is addressed from the Bayesian general framework to define the relationship between stochastic and deterministic approaches. Moreover, both ZRLS and SM applications applied to fault detection are assessed taking as a reference the minimum detectable fault in the worst case. Finally, a well‐known quadruple‐tank process is used to illustrate the estimation and fault detection results.
Coupling Fe(II)/Fe(III) Redox Mediated SO2 Conversion with Hydrogen Production
Authors: Wu Ze , Zhang Yiqiong , Zhang Li , Zhou Bo , Wei Zengxi , Wang Dongdong , Lu Wenbo , Jia Jianfeng , Tao Li , Wang Tehua , Wang Shuangyin 
Published: January 2023

AbstractWater electrolysis is recognized as a green hydrogen production technology, but the high voltage required for anodic oxygen evolution reaction restricts the practical application. In this work, a Fe(II)/Fe(III) redox mediated SO2 conversion is proposed to couple the cathodic hydrogen evolution reaction to achieve sulfur dioxide conversion and hydrogen production at low voltage. The onset potential of Fe(II) electrooxidation to Fe(III) is as low as 0.75 VRHE (vs reversible hydrogen electrode). Ex situ ultraviolet spectroscopy (UV) spectrum and ion chromatography indicate that SO2 in electrolyte can reduce Fe(III) to Fe(II), completing the Fe(II)/Fe(III) redox cycle as well as the conversion of SO2 to sulfuric acid. The assembled flow cell electrolyzer requires a low operating voltage of 0.97 V at 10 mA cm−2 and shows good performance under both acidic and neutral conditions. This study proposes an innovative energy saving and environment friendly strategy for simultaneous hydrogen production and sulfur dioxide capture based on low‐cost catalyst materials.
Controlled Adhesion of Ice—Toward Ultraclean 2D Materials
Authors: Liu Haijun , Thi Quoc Huy , Man Ping , Chen Xin , Chen Tianren , Wong Lok Wing , Jiang Shan , Huang Lingli , Yang Tiefeng , Leung Ka Ho , Leung Tsz Tung , Gao Shan , Chen Honglin , Lee Chun‐Sing , Kan Min , Zhao Jiong , Deng Qingming , Ly Thuc Hue 
Published: January 2023

AbstractThe scalable 2D device fabrication and integration demand either the large‐area synthesis or the post‐synthesis transfer of 2D layers. While the direct synthesis of 2D materials on most targeted surfaces remains challenging, the transfer approach from the growth substrate onto the targeted surfaces offers an alternative pathway for applications and integrations. However, the current transfer techniques for 2D materials predominantly involve polymers and organic solvents, which are liable to contaminate or deform the ultrasensitive atomic layers. Here, novel ice‐aided transfer and ice‐stamp transfer methods are developed, in which water (ice) is the only medium in the entire process. In practice, the adhesion between various 2D materials and ice can be well controlled by temperature. Through such controlled adhesion of ice, it is shown that the new transfer methods can yield ultrahigh quality and exceptional cleanliness in transferred 2D flakes and continuous 2D films, and are applicable for a wide range of substrates. Furthermore, beyond transfer, ice can also be used for cleaning the surfaces of 2D materials at higher temperatures. These novel techniques can enable unprecedented ultraclean 2D materials surfaces and performances, and will contribute to the upcoming technological revolutions associated with 2D materials.
Recent Advances in Efficient Photocatalysis via Modulation of Electric and Magnetic Fields and Reactive Phase Control
Authors: Dai Baoying , Guo Jiahao , Gao Chenchen , Yin Hang , Xie Yannan , Lin Zhiqun 
Published: January 2023

AbstractThe past several years has witnessed significant progress in enhancing photocatalytic performance via robust electric and magnetic fields’ modulation to promote the separation and transfer of photoexcited carriers, and phase control at reactive interface to lower photocatalytic reaction energy barrier and facilitate mass transfer. These three research directions have received soaring attention in photocatalytic field. Herein, recent advances in photocatalysis modulated by electric field (i.e., piezoelectric, pyroelectric, and triboelectric fields, as well as their coupling) with specific examples and mechanisms discussion are first examined. Subsequently, the strategy via magnetic field manipulation for enhancing photocatalytic performance is scrutinized, including the spin polarization, Lorentz force, and magnetoresistance effect. Afterward, materials with tailored structure and composition design enabled by reactive phase control and their applications in photocatalytic hydrogen evolution and carbon dioxide reduction are reviewed. Finally, the challenges and potential opportunities to further boost photocatalytic efficiency are presented, aiming at providing crucial theoretical and experimental guidance for those working in photocatalysis, ferroelectrics, triboelectrics, piezo‐/pyro‐/tribo‐phototronics, and electromagnetics, among other related areas.
Composite Hydrogel for Spatiotemporal Lipid Intervention of Tumor Milieu
Authors: Ma Jia , Guo Daoxia , Ji Xiaoyuan , Zhou Yanfeng , Liu Chang , Li Qian , Zhang Jiye , Fan Chunhai , Song Haiyun 
Published: January 2023

AbstractInduction of immunogenic cell death (ICD) plays crucial roles in cancer immunotherapy, whereas its efficacy is severely compromised by redundant antioxidant defenses in cancer cells and aberrant lipid metabolism in immunosuppressive cell populations. In this work, it is found that hollow mesoporous CuS nanoparticles (NPs) possess an intrinsic capacity of inhibiting glutathione peroxidase 4 (GPX4). When loaded with an inhibitor of the ferroptosis suppressor protein 1 (FSP1), these NPs block two parallel redox systems and cooperate with near‐infrared irradiation to reinforce ICD. A hydrogel co‐delivering cancer‐cell‐targeting CuS NPs and immunosuppressive‐cell‐targeting sulfo‐N‐succinimidyl oleate (SSO) for spatiotemporal lipid intervention i further fabricated. While the CuS NPs augment ICD via synergistic lipid peroxidation, SSO reinstates immune perception via lipid metabolic reprogramming, thereby coordinately triggering robust innate and adaptive immunity to restrain tumor growth, relapse, and metastasis. This study provides an immunometabolic therapy via orchestrated lipid modulation in the tumor milieu.
Integrating Graphene Enables Improved and Gate‐Tunable Photovoltaic Effect in Van der Waals Heterojunction
Authors: Liu Zihao , Shu Kaixiang , Yang Yujue , Yu He , Huang Ying , Gao Wei , Zhang Xin , Wu Fugen , Li Jingbo , Dong Huafeng , Huo Nengjie 
Published: January 2023

AbstractVan der Waals (vdW) heterojunction has emerged as promising building blocks for the next generation of optoelectronics, which can fulfill the increasing demands of miniaturization, high density of integration, and low power consumption. The photovoltaic effect is one of the crucial functions for fast photo‐detection and energy‐harvesting applications. Here, graphene is integrated into vdW WS2/WSe2 heterojunction, the graphene can serve as electron and hole transport layers, boosting the collection efficiency of photo‐excited carriers and thus improving the photovoltaic effect. The graphene‐integrated device exhibits superior power‐conversion‐efficiency (PCE) up to 9.08%, one order of magnitude improvement compared to the device with metal‐WS2/WSe2‐metal configuration. Moreover, the back gate has great modulation on its photovoltaic effect due to the large gate‐tunability of band bending at the interface. Operating as self‐driven photo‐diode, it also achieves outstanding photodetection performance with high photo‐switching ratio of 1 × 106, high detectivity (D*) of 2.66 × 1012 Jones, and fast speed of 110 µs, all the parameters are improved by nearly one order of magnitude compared to the device without graphene integration. This work provides a universal approach by integrating graphene as vdW contact to significantly improve the photovoltaic effect and photodetection property toward highly efficient energy‐harvest and photodetector applications.
High cholesterol levels change the association of biomarkers of neurodegenerative diseases with dementia risk: Findings from a population‐based cohort
Authors: Perna Laura , Mons Ute , Stocker Hannah , Beyer Léon , Beyreuther Konrad , Trares Kira , Holleczek Bernd , Schöttker Ben , Perneczky Robert , Gerwert Klaus , Brenner Hermann 
Published: January 2023

AbstractIntroductionThis study assessed whether in a population with comorbidity of neurodegenerative and cerebrovascular disease (mixed pathology) the association of glial fibrillary acidic protein (GFAP), neurofilament light chain (NfL), and phosphorylated tau181 (p‐tau181) with dementia risk varied depending on levels of total cholesterol and apolipoprotein E (APOE) ε4 genotype.MethodsPlasma biomarkers were measured using Simoa technology in 768 participants of a nested case‐control study embedded within an ongoing population‐based cohort. Logistic and spline regression models, and receiver operating characteristic curves were calculated.ResultsThe strength of the association between GFAP and NfL with risk of a clinical diagnosis of dementia changed depending on cholesterol levels and on APOE ε4 genotype. No significant association was seen with p‐tau181.DiscussionIn individuals with mixed pathology blood GFAP and NfL are better predictors of dementia risk than p‐tau181, and their associations with dementia risk are amplified by hypercholesterolemia, also depending on APOE ε4 genotype.HIGHLIGHTS
Cholesterol levels changed the association of blood biomarkers with dementia risk.
Blood biomarkers seem to perform differently in community‐ and clinic‐based cohorts.
Neurofilament light chain might be a biomarker candidate for dementia risk after stroke.
Endowing Polythioester Vitrimer with Intrinsic Crystallinity and Chemical Recyclability
Authors: Shi Changxia , Zhang Zhen , Scoti Miriam , Yan Xiao‐Yun , Chen Eugene Y.‐X. 
Published: January 2023

AbstractTechnologically important thermosets face a long‐standing end‐of‐life (EoL) problem of non‐reprocessability, a more sustainable solution of which has resolved to nascent vitrimers that can merge the robust material properties of thermosets and the reprocessability of thermoplastics. However, the lifecycle of vitrimers is still finite, as they often suffer from significant deterioration of mechanical performance following multiple reprocessing cycles, analogous to mechanical recycling, and they often show undesired creep under working conditions. To address these two key limitations, we have developed a cross‐linked semi‐crystalline polythioester with both dynamic covalent bonds and intrinsic crystallinity and chemical recyclability, affording a vitrimeric system that exhibits not only reprocessability and crystallinity‐restricted creep but also complete chemical recyclability to initial monomer by catalyzed depolymerization in solution or bulk. Therefore, reported herein is an “infinite” vitrimer system that is empowered with a facile closed‐loop EoL option once serial reprocessing deteriorates performance and the material can no longer meet the application requirements. Specifically, the polythioester vitrimer was constructed by copolymerization of a bicyclic thioester with a bis‐dithiolane, producing dynamically cross‐linked polythioesters with excellent property tunability, from amorphous to semi‐crystalline states and melting transition temperatures from 91 to 178 °C.
Postvoid residual bladder volume after uncomplicated vaginal delivery
Authors: Degasper Christine , Späth Laura , Fessler Siegfried , Widschwendter Andreas , Abdel Azim Samira , Ritter Magdalena 
Published: January 2023

AbstractObjectiveTo create a reference curve for postvoid residual volume (PVRV) in asymptomatic postpartum women who are at low risk of developing postpartum urinary retention (PUR), a well‐known complication in the immediate postpartum period.MethodsThis is a prospective observational study measuring PVRV after uncomplicated vaginal delivery. PVRV was assessed by transabdominal ultrasound using a portable ultrasound scanner within the first 26 h after delivery (PVRV 1) and on the day of discharge (day 2 or 3 postpartum) (PVRV 2). A PVRV of 150 mL or more was defined as the cut‐off value for covert PUR.ResultsThe prevalence of covert PUR was 7.1%. Primiparity, duration of second stage, and obstetric injury were correlated with higher PVRV 1. The median PVRV 1 was 21 mL and PVRV 2 was 11 mL. The subgroup of nulliparous women had a significantly higher PVRV 1 compared with multiparous women. At discharge, the majority (99.1%) of women had a PVRV of less than 150 mL.ConclusionAsymptomatic women were at low risk of developing PUR. However, women with a prolonged second stage may benefit from a routine postpartum assessment. Our results allow for a better understanding of PVRV in the early postpartum period.
Evaluation of an electronic health record documentation tool use to improve pharmacist intervention tracking in the intensive care unit
Authors: Vlashyn Olga O. , Murphy Claire V. , Cape Kari , Phelps Megan K. , Nunez Samara M. , Hafford Amanda , Jordan Trisha A. , Smetana Keaton S. 
Published: January 2023

AbstractPurposePharmacists are integral members of the healthcare team, but interventions are not always captured due to documentation limitations. This study evaluated the impact of implementing a tracking tool to address gaps in capturing pharmacist interventions.MethodsA prospective, observational study was conducted to assess pharmacist interventions between July and November 2020. Twelve critical care pharmacists captured interventions on 10 weekdays using a tracking tool (iVent—Epic®) embedded in the electronic medical record (EMR) to capture high frequency interventions not standardly captured via existing standard note documentation (e.g., renal/hepatic dose adjustment, parenteral nutrition management). Value added of the interventions is proposed. Patients' baseline demographics, interventions, Sequential Organ Failure Assessment (SOFA) score, and intensive care unit (ICU) length of stay (LOS) were collected. The primary outcome was to determine the added benefit of using a tracking tool within the EMR to capture pharmacist interventions compared to progress note documentation.ResultsTwo thousand seven hundred and eighty‐three interventions were documented on 514 unique patients over 120 pharmacist shifts. Of these, 2363 (84.9%) interventions were captured through iVent tracking. The median SOFA score on day of intervention was 4 [interquartile range (IQR) 2–7] and ICU LOS was 3.5 days [IQR 1.5–9]. The median number of interventions per patient per day was 2 [IQR 1–3]. A significant difference was observed among days of the week and the number of iVents documented (χ2 = 13.172, p = 0.01, df = 4). The post hoc pairwise comparison revealed more documented iVents on Tuesday than Friday.ConclusionThis study reveals that an iVent tracking tool increased total capture of pharmacist interventions by 563%. These interventions can be associated with value‐based programs and further work is needed in highlighting the pharmacist's role in these new payment models. This study confirms that the current standard practice at this institution of solely entering pharmacist progress notes into the patient chart misses a majority of pharmacist interventions.
Detection of thin‐cap fibroatheroma in IVOCT images based on weakly supervised learning and domain knowledge
Authors: Shi Peiwen , Xin Jingmin , Wu Jiayi , Deng Yangyang , Cai Zhuotong , Du Shaoyi , Zheng Nanning 
Published: January 2023

AbstractAutomatic detection of thin‐cap fibroatheroma (TCFA) on intravascular optical coherence tomography images is essential for the prevention of acute coronary syndrome. However, existing methods need to mark the exact location of TCFAs on each frame as supervision, which is extremely time‐consuming and expensive. Hence, a new weakly supervised framework is proposed to detect TCFAs using only image‐level tags as supervision. The framework comprises cut, feature extraction, relation, and detection modules. First, based on prior knowledge, a cut module was designed to generate a small number of specific region proposals. Then, to learn global information, a relation module was designed to learn the spatial adjacency and order relationships at the feature level, and an attention‐based strategy was introduced in the detection module to effectively aggregate the classification results of region proposals as the image‐level predicted score. The results demonstrate that the proposed method surpassed the state‐of‐the‐art weakly supervised detection methods.
Residents as gratuitous referrals at destination: An integrative model from altruistic values to pro‐tourism behavior
Authors: Plaza‐Mejía María Ángeles , Haldon‐Hermoso Juana María , Porras‐Bueno Nuria 
Published: January 2023

AbstractThe altruistically shared information provided by residents is significant for travelers, affecting decisions they postpone until arrival at their destination. This study integrates altruism as a personal value with the basic postulates of social exchange theory and theory of reasoned action to explain the behavior of residents in terms of gratuitous referrals at destination (GRAD). A structural equation model is tested at a tourist destination on the coast of southwestern Spain. The results reveal that the factors influencing residents' attitude toward GRAD behavior (GRB) substantially differ from those that condition attitude toward tourism more generally. Furthermore, the altruistic values of residents indirectly condition their GRB.
Competition between a manufacturer and a relicensing third party when customers are strategic
Authors: Zhu Qingyuan , Yu Chenghao , SHEN Zhiyang , Song Malin 
Published: January 2023

AbstractThis study presents an analytical framework for examining how remanufacturing rate, consumer buying behavior, and consumer preferences impact a supply chain's economic and environmental outcomes. An original equipment manufacturer and a third‐party remanufacturer make decisions influenced by the competitive leverage of relicensing fees and the maximum available quantity of remanufactured products. We analyze this monopoly scenario in a two‐period model, assuming that consumers are strategic. The remanufacturing rate has a nonmonotonic impact on the economic outcomes of this supply chain system, and excellent environmental improvement is not an inevitable consequence of a high remanufacturing rate.