bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of α-Tocopherol on Viability, Lipid Peroxidation and Oxidative Stress of Cryopreserved Ovine Preantral Follicle
Authors: Kaushik Kalpana , Pulukuri Johnson , Tej NikhilK , Krishna Kavya , Gupta Paluru S.P. , Nandi Sumanta , Mondal Sukanta 
Published: December 2022

Vitrification of preantral follicles is a promising technique to preserve female fertility. The aim of the present study was to evaluate the effect of supplementation of α-tocopherol in the vitrification solution on the viability, lipid peroxidation and mRNA expression of superoxide dismutases (SOD1 and SOD2) in vitrified cultured ovine preantral follicles at day-6 and day-12. Preantral follicles (200-300 µm) were isolated from the ovine ovaries by the mechanical method and were distributed separately to the vitrification medium supplemented with 10 mM and 20 mM of α-tocopherol. After a week, the follicles were thawed and analyzed for follicular viability by trypan blue dye exclusion method and subjected to in vitro culture (IVC) for 6 and 12 days. Our results revealed that the significant increase (p<0.05) of viability in 20 mM α-tocopherolsupplemented vitrified group when compared to the vitrified without α-tocopherol group. On day-6 of IVC, malondialdehyde (MDA) concentration was significantly(p<0.05) higher in vitrified group without α-tocopherol in comparison to vitrified supplemented with 20 mM of α-tocopherol and control fresh groups. However, no significant difference in MDA content was found among the groups at day-12. The mRNA expression level of SOD1 at day-6 was significantly (p<0.05) higher in vitrified with 20 mM of α-tocopherol and control fresh groups compared to the vitrified without α-tocopherol and with10 mM α-tocopherol groups. The expression pattern of SOD2 was significantly (p<0.05) higher in control fresh group compared to the other groups at day-6 and day-12 of IVC.We conclude that lowering the vitrification-induced lipid peroxidation of preantral follicles by α-tocopherol at 20 mM concentration may be mediated by increasing SOD expression during IVC.
Thallium Induced Sub-chronic Toxicity Profile in Wistar Rats
Authors: Sindhi Parvez I. , Raval Samir H. , Singh Ratn Deep , Parmar Rohit S. , Patel Jasmi G. , Patel Bakor J. , Joshi Dilip V. 
Published: December 2022

Thallium (Tl) is one of the most toxic heavy metals affecting both humans and animals, yet is one of the least studied for its toxicological effects. A total of 40 male Wistar rats were randomly divided into four Groups with 10 rats in each Group. Group I received distilled water only and served as a control. Group II, III, and IV received thallium sulfate (I) at 0.48, 0.93, and 1.33 mg/kg body weight, respectively, in drinking water for 90 days. In Group IV rats, lethargy, dehydration, weakness, mild diarrhea, weight loss and 100% morality in male Wistar rat were noted. Group II and III rats showed significant reduction in cholesterol, phosphorus, triglyceride level, and absolute and relative spleen weight. Microscopically, thallium sulfate (I) found to cause lymphoid depletion in white pulp of spleen in all treatment Groups. In kidney of Group IV rats, tubular necrosis, cytoplasmic vacuolation or clearing of tubules, cast, and thrombosis were found. Dose dependent hyperkeratosis was found in non-glandular stomach in all three treated Groups. In conclusion, spleen, kidney and stomach were primarily affected organs in sub-chronic thallium toxicity.
Sensitivity of Campylobacter jejuni Virulence genes flaA,mapA and hipO by Polymerase chain reaction
Authors: Marimuthu Dhanalakshmi , Sekar Muthu , L Gunasaleen , Vivekanandan Bhanurekha , Singaram Balakrishnan , Raj Gopal Dhinakar 
Published: December 2022

Campylobacter jejuni is more frequently associated with zoonotic bacterial cause of foodborne gastroenteritis in humans. Effective diagnosis of C. jejuni infection in various matrix like foods of animal origin, environment and human is crucial to maintain public health. Since molecular diagnosis of C. jejuni carries several advantages over conventional microbial culture techniques, in this study, the limit of detection for the selected virulence genes of C. jejuni (flaA,mapA and hipO) were evaluated to know the suitability of them to be used as molecular diagnostic targets for early detection of C. jejuni by in- house designed primers by conventional PCR. Analytical sensitivity of these genes were assessed in terms of Colony Forming Units (103 CFU/ ml, 102 CFU/ ml, 101 CFU/ ml, 100 CFU/ ml) and DNA concentration (100 ng,10 ng, 1 ng, 100 pg, 10 pg and 1 pg ) of C jejuni cultures. Results revealed that the primers targeting flaA have superior limit of detection as 10CFU and 1pg of C. jejuni DNA. Whereas mapA and hipO have 10 CFU; 10 pg DNA and 100 CFU ;10 ng DNA detection limit respectively. Gene mapA had comparable detection limits in terms of CFU with flaA but found to be less sensitive with respect to DNA concentration but hipO has 102 fold lesser limit of detection.
Mesothelioma – Cytological Studies and Medical Management in a Non-Descript Dog – A Case Report
Authors: Sundararajan RC , K Preethi , K Gopal , D Vishnugurubaran , V Vijayanand , M Balagangatharathilagar 
Published: December 2022

Mesotheliomas are tumors of low grade malignancy originating from mesothelial cells covering the coelomic cavities such as the pericardium, pleura, peritoneum and vaginal tunic (Seo et al., 2007). The three types of mesotheliomas are epithelial, fibrous (arcomatous) and biphasic (mixed). The epithelial form, which closely resembles the carcinoma and adenocarcinoma, is the most common type of mesothelioma in dogs (Echandi et al., 2007). Pleural effusion is one of the most classical characteristic feature of mesothelioma. They cause minimal tissue invasion and rarely metastasis to other regions (Vural et al., 2007). In addition to viral or genetic factors long term exposure to dusts such as asbestos, iron or silica plays a major role in the pathogenesis of this neoplasm. It is more common in older animals than younger animals (Echandi et al., 2007). The major clinical sign of this condition occurs due to the accumulation of fluid in the body cavities (Seo et al., 2007). The cytological analysis of the fluid helps to determine the cause of pleural effusion and to make rapid diagnosis (Martin et al., 2011). The morphology of the mesothelial cells are round to polygonal in outline, with anisocytosis, anisokaryosis, pleomorphic multi-nucleated cells, minimal eosinophilic or basophilic cytoplasm, mitosis, loose chromatin, evident nucleoli and ovoid to angulated vesicular nucleus (Martin et al., 2011).
'Do you own your freedom?' Reflecting on Cape Town youths' aspirations to be free
Authors: Brown-Luthango Mercy , Van Rooyen Rosca 
Published: December 2022

Young people make up half of the world’s population and constitute the majority of the population across the Global South (Cooper et al. 2019). In South Africa, the youth constitute one-third of the country’s population, many of whom belong to the so-called ‘born free’ generation. The ‘born free’ generation typically refers to those who were born after the end of Apartheid, or those who were coming of age after 1994. The youth, particularly in cities of the South, represent an excluded majority in terms of access to meaningful employment and quality living environments.
This article reflects on a research project which used narrative photovoice as a method to engage a group of 13 young people from Mitchell’s Plain, Philippi and Gugulethu; poor marginalised areas in Cape Town. Narrative photovoice combines photography with writing to give participants an opportunity to convey particular stories or issues through their photography. Through a process of co-production and collaboration between academic researchers, a community-based organisation (CBO) called ‘Youth for Change’ and a creative enterprise called ‘noDREAD’productions, the youth were engaged in a creative process using photographs to tell stories about themselves, their communities and the broader city context in which they live.
This article draws on Appadurai’s notion of the ‘capacity to aspire’ to make sense of the aspirations and dreams the participants talk about through their photographs; how they navigate structural, psychological and other factors which impede their aspirations and their freedom, and how they make sense of their everyday realities. The article advances two interlinked arguments: firstly, it makes visible the ‘navigational capacity’ of youth from marginalised neighbourhoods and their capacity to aspire amidst multiple constraints. It does so by illustrating how the youth grapple with the idea and experience of freedom in their everyday life. Secondly, it makes a case for the use of photovoice as a method that is well positioned to (a) capture the visual dimension of youth aspirations and (b) allow for co-production between the different stakeholders.
Identification of Pedestrian Preference Pattern for Central Area of Goiânia City in Brazil
Authors: Almeida Cristiano Farias , Oliveira Cássia Alencar da Silva 
Published: December 2022

The need for establishing urban mobility policies that favor pedestrians, which are the most vulnerable elements in the transit system, is known. In this sense, the study aimed to identify the pattern of pedestrian preferences on sidewalks, using the Walkability Index and Stated Preference technique. The methodology developed to achieve the objective is composed of the following steps: (i) definition of the study area, (ii) Decription of the study area, (iii) definition of variables, (iv) data collection, (v) calculation of the Walkability Index, (vi) data processing of the stated preference survey, (vii) analysis of results and definition of guidelines. A case study was carried out in the central sector of Goiânia (GO) in order to validate the presented methodology. Thus, the study proposes to investigate pedestrian preferences on sidewalks in order to provide subsidies to assist the planning of pedestrian-oriented mobility systems.
A mulher do campo: nuances do processo de alfabetização e o apoio do educador(a)
Authors: Araújo Vanda Almeida da Cunha , Leal Débora Araújo 
Published: December 2022

A trajetória da mulher para ter o direito de estudar foi marcada por muita luta, o machismo enraizado na família é o principal obstáculo para as mulheres rurais ter acesso a educação. A metodologia utilizada foi a pesquisa bibliográfica, onde possibilitou um olhar para as mulheres da zona rural e com o Estado adotar meios de inserção das mulheres do campo na educação rural. Deste modo, foi possível observar com essa presente pesquisa e gerenciar a preparação para a inserção de mulheres rurais que necessite de educação de qualidade, o que é direito de todos e ao falar de trabalho, quase todas as mulheres possuem a intenção de trabalhar e melhorar a renda da família, para isso, precisam se inserir no mercado, e para que isso ocorra é necessário uma maior e melhor formação escolar. Para as mulheres a escola abre oportunidades, pois é neste espaço que as mesmas podem melhorar sua condição de escolaridade e, dessa forma, ampliar conhecimentos, superar vários obstáculos na busca de vagas no mercado de trabalho.
PENINGKATAN KEMAMPUAN PEMECAHAN MASALAH DAN MOTIVASI BELAJAR DENGAN METODE PROBLEM SOLVING
Authors: Agusta Erna Sari 
Published: December 2022

Sebagai mata pelajaran yang dianggap sulit menyebabkan beberapa siswa kurang termotivasi dalam belajar matematika. Hal ini ditandai dengan kurang semangat dan kurang aktifnya peserta didik untuk mengikuti PBM di kelas. Selain itu, kurangnya kemampuan pemecahan masalah membuat peserta didik hanya mampu menyelesaikan masalah berdasarkan contoh soal yang diberikan. Hal ini dibuktikan dari prosentase perolehan nilai tes peserta didik yang belum mencapai KKM lebih dari 75%. Penelitian ini bertujuan untuk mengetahui peningkatan kemampuan pemecahan masalah dan motivasi belajar matematika siswa dengan diterapkannya metode problem solving. Penelitian ini menggunakan Penelitian Tindakan Kelas (PTK) sebanyak dua siklus yang terdiri dari rancangan, kegiatan dan pengamatan, refleksi, dan revisi. Subjek penelitian adalah siswa kelas IX-1 MTsN 28 Jakarta. Data diperoleh dari hasil angket motivasi siswa, hasil tes formatif, dan lembar observasi kegiatan belajar mengajar. Data dianalisis secara deskriptif kualitatif dengan menggunakan framework teknik analisis yang terdiri dari reduksi data, penyajian data, dan penarikan kesimpulan. Hasil penelitian menunjukkan bahwa nilai rata-rata kemampuan pemecahan masalah matematis siswa mengalami peningkatan dari siklus I sebesar 61,05 menjadi 75,97 pada siklus II. Jumlah siswa yang nilainya di atas KKM juga mengalami peningkatan dari 47,32% pada siklus I menjadi 83,3% pada siklus II. Begitu pun jumlah siswa yang termotivasi mengalami peningkatan untuk kategori sedang, tinggi, dan sangat tinggi mulai dari siklus I sampai siklus II. Simpulan penelitian ini adalah metode problem solving dapat meningkatkan motivasi dan kemampuan pemecahan masalah matematis siswa kelas IX-1 MTsN 28 Jakarta.
PEMANFAATAN HASIL ASESMEN NASIONAL DALAM PROGRAM PENINGKATAN MUTU PENDIDIKAN DASAR DI DKI JAKARTA
Authors: Sanmarwi Sodiyah , Sulastri Sri 
Published: December 2022

Dalam melaksanakan evaluasi sistem pendidikan pemerintah daerah didampingi oleh UPT pada Dirjen PAUD, Dikdas, dan Dikmen. Hasil evaluasi sistem pendidikan oleh pemerintah daerah dimanfaatkan sebagai bahan untuk melakukan penyesuaian kebijakan dan perencanaan program dalam rangka peningkatan akses, mutu, relevansi, dan tata kelola penyelenggaraan pendidikan. Tujuan penelitian ini adalah: diperolehnya permasalahan pendidikan yang perlu mendapat prioritas dan akar masalahnya berdasarkan indikator dalam rapor pendidikan, dan diperolehnya program kegiatan berdasarkan Permendagri nomor 59 tahun 2021. Metode yang digunakan adalah metode penelitian kualitatif dengan pendekatan studi kepustakaan. Fokus penelitian ini adalah melakukan pengolahan dan analisis rapor pendidikan yang menghasilkan permasalahan, akar masalah, dan rekomendasi program peningkatan mutu bagi pemerintah daerah. Simpulan penelitian pada jenjang SD diperoleh permasalahan pendidikan pada kemampuan numerasi, kesenjangan karakter, dan iklim kebhinekaan. Pada jenjang SMP permasalahan yang ditemukan adalah kesenjangan karakter, dan APM SMP/MTs/Paket B/SMPLB. Akar masalah yang terdapat pada jenjang SD adalah: kesenjangan karakter antarwilayah, toleransi agama dan budaya, sikap inklusif; dukungan atas kesetaraan agama dan budaya, kualitas pembelajaran, kepemimpinan instruksional, kesenjangan iklim keamanan sekolah, kesenjangan iklim kebinekaan, iklim inklusivitas, kesenjangan iklim inklusivitas, partisipasi warga sekolah, proporsi pemanfaatan sumber daya sekolah untuk peningkatan mutu, pemanfaatan TIK untuk pengelolaan anggaran, dan proporsi pemanfaatan APBD untuk pendidikan. Akar masalah yang ditemukan pada jenjang SMP adalah: kesenjangan antarkelompok gender, kesenjangan antarwilayah, APM murid disabilitas, kualitas Pembelajaran, refleksi dan perbaikan pembelajaran oleh guru, kepemimpinan instruksional, iklim inklusivitas, partisipasi warga sekolah, proporsi pemanfaatan sumber daya sekolah untuk peningkatan mutu, pemanfaatan TIK untuk pengelolaan anggaran, dan proporsi pemanfaatan APBD untuk pendidikan.
Devlet Hastanelerinde Dengeli Puan Cetveli Modelinin Güncel Uyarlaması: Kurumsal Karne ve İlgili Dönem Sonuçları
Authors: KELEŞOĞLU Salim İdris 
Published: December 2022

ÖZET
Amaç: Ülkemiz kamu sağlık tesislerinde kullanılmış olan kurumsal karne (KK) uygulamasının dönem sonuçlarını ve etkilerini değerlendirmek.
Genel Bilgi: Kamu Hastanelerimizde Sağlıkta Dönüşüm Programı çalışmaları 2003 yılında başlamıştır. Bu süreçte özgün bir model oluşturulmaya çalışıldığı ve ciddi bir hazırlık yapıldığı anlaşılmaktadır. Yasal düzenlemeler istikrarlı bir süreci gösterir nitelikte olup KK modelinin geliştirildiği görülmektedir. 2012 yılı Kasım ayında başlatılan uygulama üzerinden yaklaşık 18 ay geçmiş ve tüm veriler kayıt edilmiştir. 2013 yılı Kasım ayında ilk karneler ya da diğer bir deyimle ara karneler düzenlenmiştir.
Gereç ve Yöntemler: Bu araştırmada Sağlık Bakanlığı bünyesinde İzmir ili içerisindeki 17 sağlık tesisi çalışma kapsamına alınmıştır. Verilerin istatistik değerlendirmesi eşleştirilmiş iki örneklem Student t testi ile yapılmıştır.
Sonuç: KK modelinin genel anlamda olumlu yönde gelişmeler sağladığı, devam eden süreçte akreditasyon kuruluşlarının beklentileri doğrultusunda, çalışmaların uluslararası başarıya dönüşmesi için geliştirilmesi gerektiği anlaşılmaktadır.
Civil Litigation Against Third-Country Defendants in the EU: Effective Access to Justice as a Rationale for European Harmonization of the Law of International Jurisdiction
Authors: Poesen Michiel 
Published: December 2022

The European Union has taken on an active role in harmonizing the law of international jurisdiction over civil and commercial court disputes. However, the jurisdictional rules contained in the key instrument in the area – the Brussels Ia Regulation – only apply to disputes involving EU-based defendants, save for a few exceptions where defendants domiciled in third countries are also covered. This article will explore the rationale for harmonizing the law of jurisdiction applicable to third-country defendants. This central theme is of particular interest, since further harmonization is once again on the EU’s agenda because of the upcoming revision of the Brussels Ia Regulation. The article will outline that proposals for harmonization are rooted in the aspiration to further effective access to justice. Moreover, it will demonstrate that far from a readily implementable programme, furthering access to justice is a multifaceted aim, the pursuit of which potentially has profound ramifications for the EU rules on civil jurisdiction.
civil litigation, third-country defendants, law of jurisdiction, PIL, conflict of laws, Brussels Ia Regulation, harmonization
Satellite Launch and Production Services and Arbitration in the Chinese Private Sector
Authors: Tay Charles 
Published: December 2022

China has grown to become one of the largest producers and launchers of rockets and satellites in recent years. Both Chinese private companies and state-owned enterprises (SOEs) are in this sector, and there are reports of satellite launch and sale contracts being signed between Chinese and foreign parties. Over the past decade, South Korea, India, the United States, France and other countries have had experience with very large arbitration claims being made arising from satellite contracts. Chinese companies have not yet had such arbitrations, but they may in the future. What likely issues might such arbitrations involve? This article examines.
Arbitration, commercial space contracts, satellites, launch services, production services, China, Belt and Road
INCLUSÃO DE PESSOAS COM DEFICIÊNCIA: OS DESAFIOS DA EDUCAÇÃO INCLUSIVA
Authors: Pereira Mônica Alves de Matos , Souza Aparecida Carina Alves de , Damasceno Allan Rocha 
Published: December 2022

O objetivo desse artigo foi dialogar com a inclusão de pessoas com deficiência, bem como o surgimento de um ambiente escolar contextualizado nos acontecimentos históricos. O cenário mundial da educação nos leva a configurar e analisar melhores condições para uma educação inclusiva para que o ensino e aprendizagem das pessoas com deficiência se efetive de forma digna e respeitosa, garantindo os direitos assegurados por lei.
PENGARUH LINGKUNGAN EKSTERNAL DAN LINGKUNGAN INTERNAL TERHADAP KINERJA UKM MELALUI KEUNGGULAN BERSAING PADA UKM DI KOTA SORONG
Authors: Pereira Lino , Rini Tutri Hanggari Citra 
Published: December 2022

This study aims to determine and analyze the influence of the external environment and the internal environment on the performance of SMEs through competitive advantage in SMEs in Sorong City. The population in this study were SMEs in the city of Sorong which included food and beverage, metal and service industries, forest products and furniture, building materials, and handicrafts totaling 539 SMEs, and the samples in this study were 135 SMEs. sampling using proportional cluster random sampling. Data analysis methods include descriptive analysis and quantitative analysis with analytical tools using SEM (Structural Equation Modeling) and AMOS (Analysis Moment of Structural) programs. The findings of this study are: 1) the external environment is proven to have a negative and significant effect on the performance of SMEs; 2) the external environment is proven to have a negative and significant effect on SME performance mediated by competitive advantage; 3) the internal environment is proven to have a positive and significant impact on the performance of SMEs; 4) the internal environment is proven to have a positive and significant effect on SME performance mediated by competitive advantage.
Implementación del aula híbrida y herramientas digitales en estudiantes de un instituto de Ica
Authors: Romani Pillpe Guillermo , Macedo Inca Keila Soledad 
Published: December 2022

El presente trabajo indaga si la implementación del aula híbrida se relaciona con las herramientas en estudiantes de un instituto. Para descubrirlo se utilizó la siguiente metodología. Un enfoque cuantitativo, nivel descriptivo bivariado. Diseño descriptivo correlacionar. La población estuvo conformada por los 20 estudiantes del Programa de estudios de Mecánica Agrícola del IESTP Federico Uranga de la Provincia de Pisco, La muestra fue finta y la técnica utilizada fue una encuesta y se aplicó un instrumento de cuestionario con 30 ítems en la escala tipo Likert para la variable aula hibrida y 22 para la variable herramientas digitales. Se hizo referencia estadística mediante la correlación de Rho de Spearman. En conclusión, corresponde a los maestros evaluar la pertinencia para aplicar las herramientas digitales en la enseñanza y posterior implementación del aula híbrida.
historiografía sobre refugiados y exiliados políticos en el siglo xx: el caso del exilio republicano español de 1939
Authors: de Hoyos Puente Jorge 
Published: December 2022

Este ensayo presenta la evolución historiográfica de los estudios sobre exilios políticos del siglo xx. Centrado en el caso español, analiza los cambios temáticos derivados de los avances de la agenda de investigación y las aportaciones de otras historiografías que han permitido aumentar la presencia de los estudios sobre las migraciones. Atenderemos a la situación actual de los refugiados en Europa que forzosamente modificará también la agenda de investigación en los próximos años.
Shaming: mogelijke aanpak van ondermijnende criminaliteit?
Authors: Bannink Barbara , Kop Nicolien 
Published: December 2022

Shaming: possible approach to organized crime?
There is a growing awareness that tackling organized crime requires more than the traditional criminal law route, which is why an innovative approach to this problem is being sought. The use of various methods of shaming are regularly considered. However, little research has been done into the usefulness of shaming as a way of combatting serious crime. This article explores three Dutch cases of organized crime in which shaming has been used. It discusses the possibilities, limitations, risks and ethical dilemmas associated with the use of government shaming.