bluuebunny/crossref_metadata_2025_split huggingface dataset:
Layered origins of lymphoid tissue inducer cells
Authors: van de Pavert Serge A. 
Published: January 2023

SummaryThe Innate Lymphoid Cell (ILC) family is a relatively recently described immune cell family involved in innate immune responses and tissue homeostasis. Lymphoid Tissue Inducer (LTi) cells are part of the type 3 (ILC3) family. The ILC3 family is the main ILC population within the embryo, in which the LTi cells are critically associated with embryonic lymph node formation. Recent studies have shown more insights in ILC origin and residency from local embryonic and tissue resident precursors. Embryonic LTi cells originating from a different hemogenic endothelial source were shown to be replaced by HSC derived progenitors in adult. This review will discuss the layered origin of the ILC3 family with an emphasis on the LTi cell lineage.
Corrosion behavior of Monofrax K‐3 refractory in borosilicate‐based model low activity waste glass melts
Authors: Xu Xinyi , Saini Rajan , Koray Akdoğan Enver , McCloy John Stuart , Goel Ashutosh 
Published: January 2023

AbstractOwing to its good chemical and thermal durabilities at high temperatures, Monofrax K‐3 refractory is widely used in nuclear waste vitrification as a lining material in melting vessels. However, the corrosion of K‐3 refractory during the vitrification of nuclear waste is a serious problem because it affects the melter's safety, performance, and lifetime. Therefore, in the present study, we have focused on unearthing the impact of glass network formers, such as SiO2, B2O3, and Al2O3, in a model nuclear waste glass composition on the corrosion of Monofrax K‐3 refractory. The corrosion tests have been performed per ASTM C621 at 1150°C for 5 days. The dimensional measurements on corroded K‐3 refractory suggest that Al2O3 and SiO2 tend to reduce the refractory corrosion (neck loss), with the effect of Al2O3 being significant. A corroded region on the K‐3 refractory at the melt–refractory interface is observed. The corrosion occurs via a coupling of the melt infiltration induced by a capillary effect and the dissolution of Al, Mg, and Fe components from K‐3 into the melt through chemical reactions. A Cr‐rich layer is retained on the glass contact surface of the corroded K‐3 refractory.
Island plant functional syndromes and competition with invasive species
Authors: Barton Kasey E. , Fortunel Claire 
Published: January 2023

AbstractIsland floras are diverse with exceptionally high rates of endemicity, and they are also severely threatened. Invasive plants are widespread on islands, but whether islands are particularly susceptible to invasion or island species are more vulnerable to displacement, or both, remains unclear. As part of the “island plant syndrome,” it has been predicted that island plants have convergently evolved conservative resource use, slow growth rates, and weak competitive abilities in response to moderate climates and the presumed absence of competition in communities with relatively low species richness. Yet, functional trait approaches have provided mixed evidence to support this prediction, and direct tests of competition as neighbour effects on plant performance are lacking. Considering the extensive environmental heterogeneity that exists within islands and among islands, it seems more likely that diverse functional strategies, spanning conservative to acquisitive, have evolved in island plants. Furthermore, assessing island plant syndrome predictions through comparisons with invasive species, which are nonrandom subsets of continental plants, is a flawed approach. Future studies that compare functional strategies of native island versus native continental plants and direct tests for competition between native and invasive island plants within the local scale at which competition occurs, and that consider non‐additivities with other simultaneous global threats, are urgently needed to conserve these biodiversity hotspots.
Taking stock of the present and looking to the future of ADHD research: a commentary on Sonuga‐Barke et al. (2023)
Authors: Agnew‐Blais Jessica , Michelini Giorgia 
Published: January 2023

The review by Sonuga‐Barke and colleagues offers a thoughtful and wide‐ranging appraisal of the current state of ADHD research, while also looking into the future to consider unresolved questions and critical next steps. Furthermore, it grapples with the tension between the need to define a coherent conceptualisation of ADHD for clinical and research purposes, while keeping an open mind to new research that challenges current consensus. In our commentary, we consider several cross‐cutting ideas discussed in Sonuga‐Barke et al., including the heterogeneous nature of ADHD, ensuring equity of translational research, and the importance of participatory research to support equitable and acceptable clinical practices for all individuals with ADHD.
The mammalian insulin antagonist S961 does not exhibit insulin receptor antagonism in rainbow trout in vivo
Authors: Talarico Giancarlo G. M. , Grégoire Mélissa , Weber Jean‐Michel , Mennigen Jan A. 
Published: January 2023

AbstractDue to their reported ‘glucose‐intolerant’ phenotype, rainbow trout have been the focus of comparative studies probing underlying endocrine mechanisms at the organismal, tissue and molecular level. A particular focus has been placed on the investigation of the comparative role of insulin, an important glucoregulatory hormone, and its interaction with macronutrients. A limiting factor in the comparative investigation of insulin is the current lack of reliable assays to quantify circulating mature and thus bioactive insulin. To circumvent this limitation, tissue‐specific responsiveness to postprandial or exogenous insulin has been quantified at the level of post‐translational modifications of cell signalling proteins. These studies revealed that the insulin responsiveness of these proteins and their post‐translational modifications are evolutionarily highly conserved and thus provide useful and quantifiable proxy indices to investigate insulin function in rainbow trout. While the involvement of specific branches of the intracellular insulin signalling pathway (e.g., mTor) in rainbow trout glucoregulation have been successfully probed through pharmacological approaches, it would be useful to have a functionally validated insulin receptor antagonist to characterize the glucoregulatory role of the insulin receptor pathway in its entirety for this species. Here, we report two separate in vivo experiments to test the ability of the mammalian insulin receptor antagonist, S961, to efficiently block insulin signalling in liver and muscle in response to endogenously released insulin and to exogenously infused bovine insulin. We found that, irrespective of the experimental treatment or dose, activation of the insulin pathway in liver and muscle was not inhibited by S961, showing that its antagonistic effect does not extend to rainbow trout.
Tax policies and agency costs
Authors: Duarte Diogo , Dupoyet Brice , Docgne Sandrine , Rouxelin Florent 
Published: January 2023

AbstractWe show that when large corporations are subject to a different tax system than smaller firms, the agency cost of under‐ and overinvestment is significantly altered. In contrast to the findings in the literature, the gap between the first‐ and second‐best investment trigger prices do not move in lockstep with variations in the corporate tax rate, as in the case of a linear tax system. We show that the gap can either widen or shrink, depending on the tax policy design and regime. In addition, we find that the agency cost under a progressive tax regime is considerably larger than the agency cost under a regressive tax regime when equityholders have to bear all the investment costs. These results are reversed when managers have the ability to issue additional debt to finance the firm's expansion and transfer part of the investment costs to bondholders.
Differences between patients with inpatient‐onset and outpatient‐onset acute lower gastrointestinal bleeding: An observational study
Authors: Fujita Minoru , Manabe Noriaki , Murao Takahisa , Suehiro Mitsuhiko , Tanikawa Tomohiro , Nakamura Jun , Ishii Katsunori , Monden Syuzo , Uji Emiko , Misawa Hiraku , Ninomiya Takehiro , Sasahira Momoyo , Chikaishi Masaya , Yo Shogen , Osawa Motoyasu , Katsumata Ryo , Ayaki Maki , Ishii Manabu , Kawamoto Hirofumi , Shiotani Akiko , Hata Jiro , Haruma Ken 
Published: January 2023

AbstractBackground and AimThe clinical severity and course of acute lower gastrointestinal bleeding (ALGIB) are believed to differ between inpatient‐onset and outpatient‐onset cases, but no reports have investigated these issues in detail. We aimed to evaluate the clinical differences between inpatient‐onset and outpatient‐onset ALGIB.MethodsMedical records of patients who had undergone emergency colonoscopy for ALGIB were retrospectively reviewed. The severity was evaluated using the NOBLADS score. Patients with obvious ALGIB relapse and/or persistent iron‐deficiency anemia after emergency colonoscopy were considered to exhibit a poor clinical course.ResultsWe reviewed 723 patients with ALGIB and divided them into the inpatient‐onset cohort (172 patients) and outpatient‐onset cohort (551 patients). Compared with the outpatient‐onset cohort, the inpatient‐onset cohort had a significantly higher proportion of patients with a poor clinical course (51.2% vs 21.6%; P < 0.001) and a significantly higher mean NOBLADS score (3.6 ± 1.1 vs 2.5 ± 1.0; P < 0.001). The most common bleeding source was acute hemorrhagic rectal ulcer (52.3%) in the inpatient‐onset cohort and colonic diverticular bleeding (29.4%) in the outpatient‐onset cohort. Multivariate analysis showed that a platelet count < 15 × 104/μL and albumin concentration < 3 g/dL were significantly associated with a poor clinical course in the inpatient‐onset cohort.ConclusionsThe clinical course was significantly worse in the inpatient‐onset cohort than in the outpatient‐onset cohort. The bleeding source, clinical characteristics, and clinical course differed between the inpatient‐onset and outpatient‐onset cohorts. The clinical course in the inpatient‐onset cohort may depend on the patient's condition at ALGIB onset.
Survival and characteristics of older adults receiving home‐based medical care: A nationwide analysis in Taiwan
Authors: Shih Chih‐Yuan , Chen Ya‐Mei , Huang Sheng‐Jean 
Published: January 2023

AbstractBackgroundIn Taiwan, the National Health Insurance Administration initiated the integrated home‐based medical care (iHBMC) program in 2016 to improve accessibility to health care for homebound patients. This study aimed to describe the characteristics of older people receiving iHBMC services in Taiwan as well as the relationship between patient characteristics and survival.MethodsAll older adults registered in the iHBMC application dataset were enrolled between March 1, 2016, and December 31, 2018. Data on social determinants of health (income level, residential area), functional status, consciousness status, nasogastric tube or urinary catheter placement, and major diseases were retrieved from the database. Data on the frequency of multidisciplinary team members' visits were collected. The survival rate was investigated using the Kaplan–Meier method. A Cox proportional hazards univariate regression was conducted to analyze factors influencing survival rates.ResultsA total of 41,079 patients aged ≥65 years were enrolled in iHBMC services. The results showed that the one‐year survival rates were 72.1%, 67.4%, and 14.7% in the home‐based primary care (HBPC), home‐based primary care plus (HBPC‐Plus), and home‐based palliative care (HBPalC), respectively. Nearly two‐thirds of the HBPC‐Plus patients underwent nasogastric tube placement. The Cox proportional hazards univariate regression analysis showed that a low urbanization level, a low income level, a low functional status, and an impaired consciousness status were significant predictors of poor survival after adjustment for confounding variables.ConclusionsOlder adults receiving iHBMC services had a high mortality rate. The high rate of feeding tube use indicated that education and support for both clinical practitioners and family caregivers regarding careful hand feeding are warranted. There was a relationship between low income levels and poor survival in rural areas. Further research on whether social care could impact prognosis should be considered.
Evaluation of interdisciplinary care pathway implementation in older elective surgery patients
Authors: Hu Frances Y. , Rowe Katherine A. , O'Mara Lynne M. , Bulger Amy , Bleday Ronald , Groff Michael W. , Cooper Zara , Bernacki Rachelle E. 
Published: January 2023

AbstractBackgroundThe American College of Surgeons Geriatric Surgery Verification Program outlines best practices for surgical care in older adults. These recommendations have guided institutions to create workflows to better support needs specific to older surgical patients. This qualitative study explored clinician experiences to understand influences on implementation of frailty screening and an interdisciplinary care pathway in older elective colorectal surgery and neurosurgery patients.Study DesignSemi‐structured in‐person and video‐based interviews were conducted from July 2021 to March 2022 with clinicians caring for patients ≥70 years on the colorectal surgery and neurosurgery services. Interviews addressed familiarity with and beliefs about the intervention, intervention alignment with routine workflow and workflow adaptations, and barriers and facilitators to performing the intervention. Interviews were analyzed using the consolidated framework for implementation research (CFIR) to find themes related to ongoing implementation.ResultsThirty‐two clinicians participated (56.3% female, 58.8% White). Fifteen relevant CFIR constructs were identified. Key themes to implementation success included strong participant belief in effectiveness of the intervention and its advantage over standard care; the importance of training, reference materials, and champions; and the need for institution‐level investment in resources to amplify the impact of the intervention on patients and expand the capacity to address their needs.ConclusionSystematic evaluation found implementation of frailty screening and an interdisciplinary care pathway in elective colorectal surgery and neurosurgery patients to be supported by participating clinicians, yet sustainability of the intervention and further adoption across surgical services to better meet the needs of older patients would necessitate organizational resource allocation.
A bottom‐up modeling of metabolism of the residential building system in China toward 2050
Authors: Zhang Ling , Lu Qingqing , Yuan Zengwei , Jiang Songyan , Wu Huijun 
Published: January 2023

AbstractThis study predicted the metabolic process of the residential building system in China toward 2050 by addressing the detailed provincial patterns and urban–rural disparity and the characterizing metabolisms of building materials in detail. The results show that after a rapid growth during 1980–1990, the in‐use stocks of residential buildings in China are expected to slow down in around 2030, reaching 75 billion m2 in 2050. Urban regions will account for 80% of total stocks, and provinces in the eastern and southern coastal areas will have the largest share. As demolition lags construction, the end‐of‐life residential buildings will continue to grow steadily with huge urban–rural and provincial differences, reaching 1.4 billion m2 by 2050. Regarding the metabolism of building materials, the inflow of most materials will decrease after 2030, while the outflow will increase steadily toward inflow. Based on the recycling outlook of construction and demolition waste and the corresponding environmental benefit, it is indicated that under the Chinese government's ambitious planning and vigorous promotion, prior to the middle of the century, the building system has the potential to transition to a sustainable future that meets residents’ housing needs with a remarkable decreasing input of raw materials thereby notably decreasing pressures on the environment, which will significantly benefit the goal of carbon neutrality in China.
ESCRT‐III component OsSNF7.2 modulates leaf rolling by trafficking and endosomal degradation of auxin biosynthetic enzyme OsYUC8 in rice
Authors: Zhou Liang , Chen Saihua , Cai Maohong , Cui Song , Ren Yulong , Zhang Xinyue , Liu Tianzhen , Zhou Chunlei , Jin Xin , Zhang Limin , Wu Minxi , Zhang Shuyi , Cheng Zhijun , Zhang Xin , Lei Cailin , Lin Qibing , Guo Xiuping , Wang Jie , Zhao Zhichao , Jiang Ling , Zhu Shanshan , Wan Jianmin 
Published: January 2023

AbstractThe endosomal sorting complex required for transport (ESCRT) is highly conserved in eukaryotic cells and plays an essential role in the biogenesis of multivesicular bodies and cargo degradation to the plant vacuole or lysosomes. Although ESCRT components affect a variety of plant growth and development processes, their impact on leaf development is rarely reported. Here, we found that OsSNF7.2, an ESCRT‐III component, controls leaf rolling in rice (Oryza sativa). The Ossnf7.2 mutant rolled leaf 17 (rl17) has adaxially rolled leaves due to the decreased number and size of the bulliform cells. OsSNF7.2 is expressed ubiquitously in all tissues, and its protein is localized in the endosomal compartments. OsSNF7.2 homologs, including OsSNF7, OsSNF7.3, and OsSNF7.4, can physically interact with OsSNF7.2, but their single mutation did not result in leaf rolling. Other ESCRT complex subunits, namely OsVPS20, OsVPS24, and OsBRO1, also interact with OsSNF7.2. Further assays revealed that OsSNF7.2 interacts with OsYUC8 and aids its vacuolar degradation. Both Osyuc8 and rl17 Osyuc8 showed rolled leaves, indicating that OsYUC8 and OsSNF7.2 function in the same pathway, conferring leaf development. This study reveals a new biological function for the ESCRT‐III components, and provides new insights into the molecular mechanisms underlying leaf rolling.
Setting contextual conditions to resolve grand challenges through responsible innovation: A comparative patent analysis in the circular economy
Authors: Liu Yipeng , Xing Yijun , Vendrell‐Herrero Ferran , Bustinza Oscar F. 
Published: January 2023

AbstractThis article draws on responsible innovation (RI) undertaken by hybrid organizations, institutional rigidity, and national innovation systems (NISs) to assess and contextualize the innovation performance of for‐profit firms seeking to resolve grand challenges (GCs). The extant research on RI lacks the theoretical underpinnings to profile the unique characteristics of RI firms and the contextual conditions behind the resolution of GCs through RI. This study aims to fill this important gap by focusing on a specific type of RI firm—a firm seeking to reduce climate change through implementation of a circular economy model. By studying a multi‐country sample of 1153 manufacturing firms, we implemented propensity score matching (PSM) and the Heckman selection model to compare the patent productivity of RI and non‐RI firms. Our evidence demonstrates that RI firms display lower likelihood of patenting and lower patent productivity than non‐RI firms when they do engage in patenting. Furthermore, we found that a stronger national R&D environment can be conducive to aligning public interests and private incentives by enabling RI firms to enhance their patent productivity. Additionally, RI firms in industries with lower levels of technological complexity capture more value from improvements in R&D environments than RI firms in industries with higher levels of technological complexity. Our argument as a whole contributes to the GC and RI literature streams by considering both the innovation barriers faced by RI‐oriented firms and the macro/industry boundary conditions that enable such organizations to overcome them.
Insomnia with objective short sleep duration is associated with hypertension
Authors: Dai Yanyuan , Chen Baixin , Chen Le , Vgontzas Alexandros N. , Fernandez‐Mendoza Julio , Karataraki Maria , Tang Xiangdong , Li Yun 
Published: January 2023

SummaryInsomnia with objective short sleep duration has been proposed as the most biologically severe phenotype of the disorder associated with cardiometabolic morbidity in population‐based samples. In this study, we investigated the association between insomnia with objective short sleep duration and hypertension in a large clinical sample. We studied 348 patients diagnosed with chronic insomnia disorder based on International Classification of Sleep Disorders Third Edition criteria and 150 normal sleepers. Objective short sleep duration was defined by the median total sleep time of the sample (< 7 hr) measured with 1‐night polysomnography. Hypertension was defined based on blood pressure levels, antihypertensive medication use and/or a physician diagnosis. After adjusting for potential confounders, patients with chronic insomnia disorder who slept < 7 hr were associated with 2.8‐fold increased odds of hypertension compared with normal sleepers who slept ≥ 7 hr (odds ratio = 2.81, 95% confidence interval = 1.068–7.411) or < 7 hr (odds ratio = 2.75, 95% confidence interval = 1.005–7.542), whereas patients with chronic insomnia disorder who slept ≥ 7 hr (odds ratio = 1.52, 95% confidence interval = 0.537–4.285) or normal sleepers who slept < 7 hr (odds ratio = 1.07, 95% confidence interval = 0.294–3.904) were not significantly associated with increased odds of hypertension compared with normal sleepers who slept ≥ 7 hr. Linear regression analyses showed that, for every hour decrease in total sleep time, systolic and diastolic blood pressure increased by 1.014 mmHg (p = 0.045) and 0.923 mmHg (p = 0.015), respectively, in patients with chronic insomnia disorder but not in normal sleepers. Our findings further support that insomnia with objective short sleep duration is a risk factor for hypertension, and objective short sleep duration may be a useful marker of the biological severity of chronic insomnia disorder in clinical practice.