bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of The Nutritional Habits of Individuals With and Without a COVID-19 Diagnosis: An Online Cross-Sectional Study From Türkiye
Authors: ATUK KAHRAMAN Tutku , YILMAZ Müge 
Published: September 2023

Objective: Türkiye, which is located in the European Region of the World Health Organization (WHO) has been also affected by the Coronavirus Disease-2019 (COVID-19) pandemic. This study was conducted between January and April 2021, in which the number of daily COVID-19 cases increased from an average of 8,500 to 50,000. This cross-sectional online study aimed to compare the dietary habits of individuals with and without a COVID-19 diagnosis.
Material and Method: The study included a total of 1,448 individuals aged 18-64 years. Study data were collected through the Google platform using a questionnaire that included sociodemographic characteristics, COVID-19 status, anthropometric measurements, physical activity status, and nutritional characteristics.
Results: Those with COVID-19 had higher Body Mass Index (BMI) than those without COVID-19. The rates of those who had regular physical activity, considered nutrition important for protection from COVID-19, and ordered food online were lower among those participants with COVID-19 than those without COVID-19. The rates of those who lost appetite and weight, used nutritional supplements, increased their nutritional budget during the pandemic, and shopped for food from online marketplaces were higher too among those with COVID-19. Those with COVID-19 were found to consume red meat, fruit, and herbal tea more frequently and soft drinks less frequently than those without COVID-19.
Conclusion: In line with these results, it may be considered that those with COVID-19 try to comply with healthy nutrition recommendations. Our results can be used to prepare appropriate nutritional guidelines for pandemic and quarantine periods.
The 6-item Self-Efficacy Scale in the Management of Chronic Disease in Individuals with Multiple Sclerosis (MS-CHOYO): Validity and Reliability Study
Authors: EROĞLU Nermin , TEMİZ Gamze 
Published: September 2023

Objective: The research was methodologically planned and applied to adapt the 6-item self-efficacy scale in chronic disease management of individuals with multiple sclerosis to Turkish society.
Material and Method: The research was carried out between January 2021 and March 2021 by using the online questionnaire method with individuals with Multiple Sclerosis registered to the Turkish MS Society. To establish the validity and reliability of the self-efficacy for managing chronic disease six item scale (SEMDC- 6S), the study was carried out with a sample consisting of n=104 individuals, which was more than 10 times the number of items on the scale(six items).For test-retest reliability, the scale was administered to 20 patients twice at a two week interval.
Results: The validity of the SEMDC-6S was evaluated with language validity, construct validity, and content validity. The internal consistency coefficient (Cronbach's Alpha) was 0.95, as which was very high.The item-total correlation was examined, and accordingly, no items were excluded from the scale. According to the test-retest results, it was determined that repeated measurements did not differ significantly, and retests had a high correlation.
Conclusion: The SEMDC-6S, which was adapted to Turkish society, is a valid and reliable tool. We recommend that it should be applied in different groups and cultures to increase its evidence value.
Farklı Spor Branşlarıyla Uğraşan Sporcularda Beslenme Durumu, Diyet Kalitesi ve Besinsel Ergojenik Destek Kullanımlarının Değerlendirilmesi
Authors: KARAÇİL ERMUMCU Merve Şeyda , SAÇLI Derya 
Published: September 2023

Amaç: Bu çalışmada farklı spor branşlarıyla uğraşan sporcularda beslenme durumu, diyet kalitesi ve besinsel ergojenik destek kullanımlarının değerlendirilmesi amaçlanmıştır.
Materyal ve Yöntem: Bu çalışma farklı spor dallarıyla ilgilenen 125 sporcuda yürütülmüştür. Sporcuların genel ve demografik özellikleri, besinsel ergojenik destek kullanımı ile besinsel ergojenik destek ürünlerine yönelik tutumları sorgulanmıştır. Antropometrik ölçümleri ve 24 saatlik besin tüketim kaydı alınmıştır. Sporcuların diyet kalitesinin değerlendirilmesinde Sağlıklı Yeme İndeksi-2015 kullanılmıştır.
Bulgular: Sporcuların yaş ortalaması 21.1±3.51 yıldır. Sporcular sırasıyla takım (%64,0), dövüş (%20,8), dayanıklılık (%10,4) ve kuvvet (%4,8) sporlarını tercih etmektedir. Sporcuların üçte biri (%36,0) besinsel ergojenik destek kullanmaktadır. Sporcularda en çok tercih edilen besinsel ergojenik destek ürünleri sırasıyla sporcu içecekleri (%19,2), proteinli süt/yoğurt (%17,6), sporcu barları (%12,8), kreatindir (%11,2). Takım sporlarında yer alan sporcuların günlük ortalama toplam enerji, posa ve karbonhidrat alım miktarları, kuvvet sporlarıyla ilgilenenlerin protein alım miktarı ve dövüş sporuyla ilgilenenlerin yağ alım miktarları en yüksek bulunmuştur (p>0,05). Sporcuların sadece %2’sinin diyet kalitesinin iyi olduğu belirlenmiştir.
Sonuç: Sporcuların branşlarına özgü bireysel düzeyde yeterli, dengeli ve diyet kalitesi yüksek ve gerektiğinde besinsel ergojenik destek ürünün de eklendiği beslenme programlarının düzenlenmesi gerekmektedir.
The Relationship between COVID-19 Phobia and Health Cognitions and Psychosocial Factors
Authors: DURGU Nihan , GÜLER Cansu , ÜSTÜNDAĞ Sema , ÜNVER Gamze 
Published: September 2023

Objective: The study aimed to determine the levels of corona-phobia experienced by individuals in a broad population representative of Turkish society, and the correlation with health cognitions and psychosocial factors.
Material and Method: This descriptive, cross-sectional, and correlational study was conducted with 1620 participants who lived in different regions of Turkey. Data were collected using an information form, the COVID-19 Phobia Scale (C19P-S), and the Health Cognitions Questionnaire.
Results: The mean age of the participants was 34.13±10.90 and 62.8% of them were female. The mean score of COVID-19 phobia score was 51.84±13.53 and health cognition was 60.17±9.61. COVID-19 phobia was significantly related to cognitions of difficulty coping with illness, medical services adequacy, the awfulness of illness and the likelihood of illness. The factors influencing the C19P-S of participants were, being female, having a chronic illness, having too much impact on daily life, difficulty coping with illness, awfulness of illness, and likelihood of illness.
Conclusion: It is recommended to plan interventions to increase public awareness of COVID-19 and to reduce corona-phobia. These interventions should be especially about the negative impact of corona-phobia on people with a chronic illness and women’s mental health.
Peran Lapas Dalam Membina Wargabinaan Sebagai Upaya Pencegahan Pengulangan Tindak Pidana
Authors: Nisa Anisa Nur Ardiana 
Published: September 2023

Lembaga Pemasyarakatan Cilegon merupakan lembaga pelatihan penjara sekaligus sarana pelatihan yang melakukan pengawasan terhadap narapidana dengan membekali mereka dengan keterampilan untuk kehidupan di masa depan setelah menjalani hukuman penjara.
Permasalahan yang diteliti dalam penelitian ini adalah (1) Bagaimana program Lapas memberikan kegiatan orientasi kepada narapidana, (2) Faktor-faktor apa saja yang menghambat dan mendukung Lapas dalam memberikan orientasi kepada narapidana, (3) Solusi apa yang diterapkan Lapas untuk mengatasi kendala dalam melakukan orientasi terhadap narapidana? proses perkembangan narapidana? Metode penelitian ini menggunakan metode kualitatif. Penelitian ini menggunakan wawancara tidak terstruktur dan wawancara tatap muka dengan petugas dan narapidana atau mantan narapidana Lapas Cilegon. Tujuan peneliti menggunakan wawancara tidak terstruktur, terutama untuk mengenal sumber informasi. Kesimpulan penelitian ini adalah pelaksanaan pelatihan di Lapas Cilegon sudah sesuai dengan UU No. Undang-undang Nomor 22 Tahun 2022 tentang Pelayanan Pemasyarakatan merupakan peraturan perundang-undangan yang positif dan harus dilaksanakan untuk mencapai tujuan pemasyarakatan. Faktor pendukung upaya Lembaga Pemasyarakatan Cilegon dalam mengembangkan keterampilan narapidana antara lain kondisi penjara yang baik, pelatihan narapidana yang bersifat bottom-up, sarana dan prasarana yang memadai, serta pelatihan berbasis keluarga dan pemberian gaji. . Faktor-faktor yang menghambat upaya Lembaga Pemasyarakatan Cilegon untuk mengembangkan keterampilan narapidana antara lain kurangnya keterampilan penjaga penjara, terbatasnya pemasaran produk keterampilan dan populasi penjara yang kelebihan kapasitas.
Expression profiles of circular RNAs and interaction networks of competing endogenous RNAs in neurogenic bladder of rats following suprasacral spinal cord injury
Authors: Ruan Jimeng , Cui Xin , Yan Hao , Jia Chunsong , Ou Tongwen , Shang Zhenhua 
Published: September 2023

Background
Neurogenic bladder (NB) following suprasacral spinal cord injury (SSCI) is an interstitial disease with the structural remodeling of bladder tissue and matrix over-deposition. Circular RNAs (circRNAs) are involved in fibrotic disease development through their post-transcriptional regulatory functions. This study aimed to use transcriptome high-throughput sequencing to investigate the process of NB and bladder fibrosis after SSCI.

Methods
Spinal cord transection at the T10–T11 level was used to construct the SSCI model in rats (10–week–old female Wistar rats, weighing 200 ± 20 g). The bladders were collected without (sham group) and with (SSCI 1–3 groups) NB status. Morphological examination was conducted to assess the extent of bladder fibrosis. Additionally, RNA sequencing was utilized to determine mRNAs and circRNAs expression patterns. The dynamic changes of differentially expressed mRNAs (DEMs) and circRNAs (DECs) in different periods of SSCI were further analyzed.

Results
Bladder weight, smooth muscle cell hypertrophy, and extracellular matrix gradually increased after SSCI. Compared with the sham group, 3,255 DEMs and 1,339 DECs, 3,449 DEMs and 1,324 DECs, 884 DEMs, and 1,151 DECs were detected in the SSCI 1–3 groups, respectively. Specifically, circRNA3621, circRNA0617, circRNA0586, and circRNA4426 were significant DECs common to SSCI 1–3 groups compared with the sham group. Moreover, Gene Ontology (GO) enrichment suggested that inflammatory and chronic inflammatory responses were the key events in NB progression following SSCI. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways enrichment associated with the “Chemokine signaling pathway”, the “IL-17 signaling pathway”, and the “TGF-beta signaling pathway” suggests their potential involvement in regulating biological processes. The circRNA–miRNA–mRNA interaction networks of DECs revealed rno-circ-2239 (micu2) as the largest node, indicating that the rno-circ-2239–miRNA–mRNA–mediated network may play a critical role in the pathogenesis of SSCI-induced NB.

Conclusions
This study offers a comprehensive outlook on the possible roles of DEMs and DECs in bladder fibrosis and NB progression following SSCI. These findings have the potential to serve as novel biomarkers and therapeutic targets.
Performance of multigene testing in cytologically indeterminate thyroid nodules and molecular risk stratification
Authors: Zhou Yuanyuan , Wu Xinping , Zhang Yuzhi , Li Zhiqiang , Ge Xia , Chen Hao , Mao Yuan , Ding Wenbo 
Published: September 2023

Objective
Thyroid cancer is the third most prevalent cancer among females. Genetic testing based on next-generation sequencing may provide an auxiliary diagnosis to reduce cytologically diagnostic uncertainty. However, commercial multigene tests are not widely available and are not well-tested in the Chinese population.

Methods
In this study, we designed a multigene testing panel and evaluated its performance in 529 cytologically indeterminate thyroid nodules (Bethesda III, IV and V). The molecular data of the DNA mutations and RNA fusions of fine needle aspiration samples were reviewed in conjunction with a clinical diagnosis, pathological reports, and definitive surgery for retrospective analysis. Then, the molecular risk stratification was investigated for its accuracy in malignant risk prediction.

Results
The overall combined consistency revealed substantial agreement (Kappa = 0.726) with the sensitivity, specificity, positive predictive value, and negative predictive values of 97.80%, 82.14%, 98.99%, and 67.65%, respectively. The most common aberration was BRAFV600E (82.59%), followed by NRAS mutants (4.07%), RET fusions (3.70%), and KRAS mutants (3.15%). Two cases (0.44%) were categorized into a high-risk group, 426 cases (94.67%) were categorized into a BRAF-like group with totally histopathologic papillary patterned tumors, and 22 cases (4.89%) were categorized into a RAS-like group with 14 papillary and eight follicular patterned tumors when the cohort concurrent aberrations were excluded. Potentially aggressive features may be related to concurrent molecular alterations of BRAFV600E with TERTQ302R, and AKT1L52R, NRASG12C, NRASQ61R, and CCDC6-RET fusions.

Conclusions
This study provided a multigene panel for identifying benign nodules from cytologically indeterminate thyroid nodules to avoid unnecessary surgery. We provide further evidence for using molecular risk stratification as a promising predictor of disease outcomes. The results of this study may be limited by the extremely high prevalence of cancer in the cohort for clinical reference.
Whole-genome resequencing analysis of the medicinal plant Gardenia jasminoides
Authors: Xu Xinyu , Chen Bihua , Zhang Juan , Lan Siren , Wu Shasha 
Published: September 2023

Background
Gardenia jasminoides is a species of Chinese medicinal plant, which has high medicinal and economic value and rich genetic diversity, but the study on its genetic diversity is far not enough.

Methods
In this study, one wild and one cultivated gardenia materials were resequenced using IlluminaHiSeq sequencing platform and the data were evaluated to understand the genomic characteristics of G. jasminoides.

Results
After data analysis, the results showed that clean data of 11.77G, Q30 reached 90.96%. The average comparison rate between the sample and reference genome was 96.08%, the average coverage depth was 15X, and the genome coverage was 85.93%. The SNPs of FD and YP1 were identified, and 3,087,176 and 3,241,416 SNPs were developed, respectively. In addition, SNP non-synonymous mutation, InDel mutation, SV mutation and CNV mutation were also detected between the sample and the reference genome, and KEGG, GO and COG database annotations were made for genes with DNA level variation. The structural gene variation in the biosynthetic pathway of crocin and gardenia, the main medicinal substance of G. jasminoides was further explored, which provided basic data for molecular breeding and genetic diversity of G. jasminoides in the future.
Identification of two short peptide motifs from serine/arginine-rich protein ribonucleic acid recognition motif-1 domain acting as splicing regulators
Authors: Jiang Tao , Wang Li , Tang Liang , Zeb Azhar , Hou Yanjun 
Published: September 2023

Background
Serine/arginine-rich (SR) proteins regulate pre-mRNA splicing. However, structurally similar proteins often behave differently in splicing regulation and the underlying mechanisms are largely unknown. Here, using SMN1/2 minigenes we extensively analyzed four SR proteins, SRSF1/5/6/9.

Methods
In this study, the effects of these proteins on SMN1/2 exon 7 splicing when tethered at either intron 6 or 7 were evaluated using an MS2-tethering assay. Deletion analysis in four SR proteins and co-overexpression analysis were performed.

Results
Splicing outcomes varied among all four SR proteins, SRSF1 and SRSF5 function the same at the two sites, acting as repressor and stimulator, respectively; while SRSF6 and SRSF9 promote exon 7 inclusion at only one site. Further, the key domains of each SR proteins were investigated, which identified a potent inhibitory nonapeptide in the C-terminus of SRSF1/9 ribonucleic acid recognition motif-1 (RRM1) and a potent stimulatory heptapeptide at the N-terminus of SRSF5/6 RRM1.

Conclusion
The insight of the four SR proteins and their domains in affecting SMN gene splicing brings a new perspective on the modes of action of SR proteins; and the functional peptides obtained here offers new ideas for developing splice switching-related therapies.
Assessment of professionalism in a chiropractic college: A design and implementation of a rubric
Authors: Voorhies Jeana L. 
Published: September 2023

ABSTRACT

Objective
To describe the design, implementation, and revision of a rubric used in assessing professionalism that was in alignment with Council on Chiropractic Education meta-competency 5 (professional ethics and jurisprudence, curricular objective C: Expected professional conduct).

Methods
The rubric was designed using a grading scale from 0 to 5 by which students needed to meet all criteria to earn full points for each defined dimension of professionalism. A comments section allowed for explanation of deductions and/or comments on exceptional behavior. Comments on professionalism were collected in a log during the trimester and used to populate the rubric. After initial use, the rubric was revised to incorporate criteria that had not initially been included and to allow for greater point deductions for multiple/repeat infractions or egregious behavior. Feedback from other faculty members was also gathered during in-service presentations of the rubric and taken into consideration. Professionalism score was 10% of the course grade.

Results
From 2016 to 2020, the average professionalism grade changed from 95.6% to 98.9%. A review of the frequency distributions of average professionalism grades in a calendar year showed that some students were earning grades between 70% and 79%. Only achieving 70% to 75% of the professionalism grade affected the final course grade by 2.5% to 3.0%.

Conclusion
In training chiropractic students on expected behaviors related to professionalism, a rubric assessment of professionalism guided communications between the clinical educator and students to discuss professionalism and remediate unprofessional behaviors. A rubric defining expected classroom behaviors aligns with educational best practices to use assessment methods to develop professionalism in health care students.
Peer review chair report: Association of Chiropractic Colleges Educational Conference and Research Agenda Conference 2023 peer review process
Authors: Johnson Claire 
Published: September 2023

ABSTRACT

Objective
The purpose of this report is to provide a summary of the methods used and feedback from reviewers about the peer review process for the 2023 Association of Chiropractic Colleges Educational Conference and Research Agenda Conference (ACC-RAC).

Methods
After the peer review process was complete, the 2023 ACC-RAC peer review committee members were invited to provide feedback through an anonymous electronic form. The survey included a Likert scale to rate items about the peer review process and an option for open-ended comments.

Results
Of the 166 peer reviewers, 77 (46%) completed the survey. The reviewers represented 9 countries, with the greatest number from North America. The majority (95%) of respondents rated the process of peer review in topic groups as good to excellent, and the majority (92%) of respondents rated the overall 2023 peer review process as good to excellent. The critical comments that were submitted are addressed in this report.

Conclusion
Overall, peer reviewer satisfaction with the process used for the 2023 ACC-RAC was high. We will include information from this report as part of the continuous quality improvement of peer review process, an important part of improving chiropractic education, research, and scholarly activities.
Antioxidant Activities of Different Solvent Extracts of Moringa oleifera Seeds Using DPPH Assay
Authors: Juliannah Famurewa, Oluwayemisi 
Published: September 2023

Moringa oleifera (Moringaceae) which grows in the tropical and subtropical regions of the world, has long unani system of medicine with ayurvedic history. The seeds are known to possess high medicinal properties. This study aimed to determine the antioxidant activity of M. oleifera seeds, extracted with different solvents (methanol, ethyl acetate and n-hexane) using 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay. This research was carried out using different concentrations of methanol, ethyl acetate, and n-hexane extracts, (5, 10, 15, 20, 25, 30 mg/mL). Vitamin C was also used as standard antioxidant control. The percentage of inhibition and IC50 were measured. The results showed that the DPPH free radicals were scavenged by all seed extracts in a concentration dependent manner. Moreover, the IC50 values for DPPH radicals with methanol, ethyl acetate and n-hexane extract of the M. oleifera seeds were found to be 30.77, 44.77 and 45.04 mg/mL, respectively. Interestingly, the IC50 value of all the extracts revealed very active antioxidant activity but lower than the standard vitamin C due to their IC50 values < 50 mg/mL. The order of activity for all the assay was methanol > ethyl acetate > n-hexane. The results suggested that methanol extract of M. oleifera seeds has the most active antioxidant activity.
Hyaline Membrane Disease in Premature Infants: A Retrospective Study
Authors: Benracon S. , Redouani M. A. , Ouadghiri I. , Barkat A. 
Published: September 2023

Introduction: Hyaline membrane disease (HMD) is an anatomoclinical entity related to a quantitative or qualitative insufficiency of pulmonary surfactant.
Patients and Methods: This was a retrospective study conducted at the National Reference Center for Neonatology and Nutrition, spread over a period of one and a half years.
Results: Antenatal corticotherapy was given in only 20% of cases. Pregnancy pathology was divided between preeclampsia, gestational diabetes and gestational hypertension. 66.6% of deliveries were by caesarean section before the onset of labour. Mean gestational age was 33.9± 1.5 weeks' amenorrhea, with 10% of patients less than 30 weeks' amenorrhea of gestational age. Mean weight was 1677 ± 463 g. The very low birth weight population (birth weight< 1500) represented 46.6%. Females predominated, with a sex ratio of 1.12. Tracheal intubation with respiratory assistance was used in 66.6% of cases. 73% of neonates received exogenous surfactant, due to the extent of hypoxemia. Progression was favourable in only 26% of cases.
Conclusion: In Morocco, Hyaline membrane disease is a major cause of neonatal morbidity and mortality, requiring rapid diagnosis and early management.