bluuebunny/crossref_metadata_2025_split huggingface dataset:
Drug–drug interactions of protein kinase inhibitors in chronic myeloid leukaemia patients: A study using the French health insurance database
Authors: Pajiep Marie , Lapeyre‐Mestre Maryse , Despas Fabien 
Published: April 2023

AbstractThe introduction of protein kinase inhibitors (PKIs) for chronic myeloid leukaemia (CML) has considerably improved prognosis of the disease but has also demonstrated a great potential for drug–drug interactions. Using the French health insurance databases, we aim to investigate the frequency, identify the associated factors and describe the potential consequences of potential drug–drug interactions (pPKI‐DIs) between PKIs and concurrent medications in CML. A retrospective cohort study has been performed among patients with CML identified in the French healthcare database from 2011 to 2014. A pPKI‐DI is defined as the presence of drugs listed as ‘interacting’ on the same day as PKI dispensing (co‐dispensing) or in its coverage period (co‐medication) during the first year of follow‐up. The list of interacting drugs is based on the summary of products characteristics (SPCs) and Thesaurus of interactions. We performed specific nested case–control comparisons to investigate the association between PKI‐DI and each of the three potential outcomes (death, hospitalisation for adverse drug reactions and switch to another PKI). We included 3480 patients; 1429 (41%) had a co‐dispensing pPKI‐DI, and 2153 (62%) had a co‐medication pPKI‐DI; 50% of the pPKI‐DIs were ‘to be taken into account’, and 17% were ‘not recommended’. The PKI with the most interactions was imatinib, and additional common drug classes included statins, benzodiazepines and proton pump inhibitors. Multivariate analysis demonstrated that the use of a higher number of additional drugs, comorbidities at baseline, high number of prescribers and higher ages were potential risk factors. Nilotinib and dasatinib showed a tendency towards a higher risk of pPKI‐DI compared to imatinib. Despite the fact that some PKI‐DIs were potentially clinically relevant, we did not find any significant association with death, hospitalisation for adverse drug reactions and switching. These findings should increase awareness to help reduce the prevalence of PKI–drug interactions and thereby ensure better management of CML patients.
Digital touch in sponsorship: Getting closer to the brand through virtual reality
Authors: Petit Olivia , Lorey Thierry , Dosquet Frédéric 
Published: April 2023

AbstractSupporters are consuming more and more sporting events through digital platforms. Brands should adapt to these new consumption patterns in order to strengthen their connection with their customers. Today, researchers and practitioners can create more interactive and enjoyable experiences through virtual reality (VR) applications. Through two studies conducted on VR during sporting events, we show that mentally representing the touch experiences of players on the field reduces the psychological distance between the supporter and the player, which strengthens the supporter's attachment to the team and, through the same attachment, to the sponsor (Study 1). We also highlight that these positive effects of VR compared to real touch (using a player's jersey) is linked to the improvement of immersion, which stimulates touch imagery (Study 2). We discuss the implications of this research for theory and practice in the sports business and other sectors.
Bio soups – new functional dehydrated soups enriched with lyophilised Fuscoporia torulosa extracts
Authors: Stojanova Monika , Pantic Milena , Klaus Anita , Mihajlovic Dragana , Miletic Dunja , Sobajic Sladjana , Stojanova Marina Todor , Niksic Miomir 
Published: April 2023

SummaryThe aim of this research was to produce a lyophilised water and ethanol extract from Fuscoporia torulosa mushroom, to determine the antimicrobial and antioxidant potential of the extracts and in industrial conditions to produce a new, functional product – Bio Soups, enriched with lyophilised extracts derived from fruiting body of F. torulosa mushroom, at the same time without use of synthetic additives. The application of the lyophilised extracts in the industrial production of dehydrated soups showed positive results. Such soups are characterised with higher (P < 0.05) antimicrobial and antioxidant activity, compared to conventional soups, while it has been proven constant biological potential and stability up to the 90th day of production. This is the first dehydrated soup enriched with lyophilised extract of medicinal mushroom, since its production does not require special conditions, and it possesses exceptional functional properties, this product could have a many times greater market potential compared to conventional soups.
Effects of dry‐curing salt content on flavour formation in different production steps during the processing of water‐boiled salted duck
Authors: Liu Ya , Liao Huiyun , Xie Qiusheng , Li Kecheng , Xu Baocai , Yao Zhong , Li Xinfu , Sun Yun 
Published: April 2023

SummaryThis study evaluated the effects of dry‐curing salt content [4% low salt (LS), 6% medium salt (MS), 8% high salt (HS)] on volatile compounds, lipid oxidation and lipolysis during the processing of water‐boiled salted duck (WSD). After dry‐curing, the varieties and content of volatile compounds increased significantly. The total content of volatile compounds tended to increase at dry‐curing, brining and early and middle air‐drying stages, and then decrease. The thiobarbituric acid reactive substances (TBARS) values increased during the whole process. The free fatty acids (FFAs) content increased at dry‐curing, brining and early air‐drying stages, and decreased after air‐drying for 1 day. Compared with LS, HS and MS had higher content of characteristic flavour substances and FFAs, especially unsaturated fatty acids (UFA), and higher TBARS during the processing of WSD. It showed that 6% dry‐curing salt content (MS) was applicable to practical production of WSD for flavour formation and salt reduction in dry‐cured meat products.
Approach to schizophrenia
Authors: Harris Anthony 
Published: April 2023

AbstractSchizophrenia is the most common of a group of psychotic disorders that occur in approximately 3% of the population over the lifespan. It has clear genetic antecedents, which are shared across the spectrum of psychotic disorders; however, a range of other biological and social factors influence the onset and treatment of the disorder. Schizophrenia is diagnosed by a characteristic set of symptoms (positive, negative, disorganisation, cognitive and affective) accompanied by a functional decline. Investigations are used to exclude other organic causes of psychosis and to provide a baseline for the negative effects of pharmacological treatments. Treatment requires a combination of pharmacological and psychosocial interventions. Physical health is poor in this group of people and this is not helped by inconsistent care from health services. Although earlier intervention has improved the immediate outcomes, the longer‐term outcome has not significantly shifted.
Newly discovered mechanisms that mediate tumorigenesis and tumour progression: circRNA‐encoded proteins
Authors: Wu Chengwei , Wang Song , Cao Tingting , Huang Tao , Xu Lishuai , Wang Jiawei , Li Qian , Wang Ye , Qian Long , Xu Li , Xia Yabin , Huang Xiaoxu 
Published: April 2023

AbstractProteins produced by cap‐independent translation mediated by an internal ribosome entry site (IRES) in circular RNAs (circRNAs) play important roles in tumour progression. To date, numerous studies have been performed on circRNAs and the proteins they encode. In this review, we summarize the biogenesis of circRNAs and the mechanisms regulating circRNA‐encoded proteins expression. We also describe relevant research methods and their applications to biological processes such as tumour cell proliferation, metastasis, epithelial‐mesenchymal transition (EMT), apoptosis, autophagy and chemoresistance. This paper offers deeper insights into the roles that circRNA‐encoded proteins play in tumours. It also provides a theoretical basis for the use of circRNA‐encoded proteins as biomarkers of tumorigenesis and for the development of new targets for tumour therapy.
Prevalence of Toxoplasma gondii‐like oocyst shedding in feral and owned cats in Damascus, Syria
Authors: Ismail Mohammad Taher , Al‐Kafri Abeer 
Published: April 2023

AbstractBackgroundThe incidence of toxoplasmosis in humans in Syria indicates an increase in the number of infections with this disease. Cats are the only definitive host of Toxoplasma gondii and excrete environmentally resistant oocysts in their feces.ObjectivesEstimate the prevalence of T. gondii‐like oocyst shedding in the cat population in Damascus, Syria.AnimalsOne‐hundred domestic cats.MethodsOne‐hundred fecal samples from cats (68 feral cats and 32 owned cats) were collected in Damascus between October and December 2017 and examined for T. gondii‐like oocysts by direct microscopic examination using Sheather's sugar flotation procedure.ResultsExamination of the samples showed that 36% (36/100) of the cats were shedding T. gondii‐like oocysts. Sporulated or unsporulated oocysts morphologically consistent with T. gondii were detected in 38.2% (26/68) of the samples collected from feral cats and in 31.3% (10/32) of the samples collected from client‐owned cats.ConclusionThe clinical importance of Toxoplasmosis in humans lies in the transmission of Toxoplasma to the fetus especially in the first trimester, resulting in severe clinical symptoms in the infant and leading to spontaneous abortion, stillbirth or other serious health problems and severe sequelae (e.g., mental retardation, blindness, hearing, and neurological disorders). Our results showed higher prevalence in Syria than in Lebanon. High amounts of T. gondii‐like oocyst shedding were detected in both feral and client‐owned cats in Damascus, emphasizing the importance of further research to understand T. gondii infection in people and animals in this region.
Optimization of stocking density and shipping duration for transportation of Pacific bluefin tuna, Thunnus orientalis (Temminck et Schlegel), eggs, and experimental verification of polyethylene glycol treatment to reduce collision damage
Authors: Hayashida Takao , Higuchi Kentaro , Hashimoto Hiroshi , Kazeto Yukinori , Takashi Toshinori 
Published: April 2023

AbstractPacific bluefin tuna (PBT), Thunnus orientalis, is one of the most important species for aquaculture worldwide. For the conservation of this species and sustainable development of the tuna farming industry, production based on closed‐cycle aquaculture should be promoted. In this study, to develop an efficient method for transporting PBT eggs, we simulated egg transportation to optimize stocking density and shipping duration, which are the two variables critical to the transportation procedure of PBT. Based on the findings of this study, we concluded that PBT eggs should be transported at a density of 1 × 104 eggs/L within 12 h in the field. Furthermore, we showed that collisions between eggs during transportation negatively affected the normal hatching rates of eggs, and polyethylene glycol (PEG) treatment (at 1000 μg/mL for 12 h) could reduce such damage. Our results suggest that PEG treatment is a practical approach that contributes to the stable transportation of PBT eggs, particularly in cases where the effects of physical shock damage is considerably increased.
(Why) Are Open Research Practices the Future for the Study of Language Learning?
Authors: Marsden Emma , Morgan‐Short Kara 
Published: April 2023

AbstractOpen research practices are relevant to all stages of research, from conceptualization through dissemination. Here, we discuss key facets of open research, highlighting its rationales, infrastructures, behaviors, and challenges. Part I conceptualizes open research and its rationales. Part II identifies challenges such as the speed and cost of open research, the usability of open data and materials, the difficulties of conducting replication research, and the economics and sustainability of open access and open research generally. In discussing these challenges, we have sought to provide examples of good practice, describe and evaluate emerging innovations, and envision change. Part III considers ongoing coevolutions of culture, infrastructure, and behaviors and acknowledges the limitations of our review and of open research practices. We argue that open research is indeed a large part of our future, and most—if not all—challenges are surmountable, but doing so requires significant changes for many aspects of the research process.
Impact of a daily legume‐based meal on dietary and nutritional intake in a group of omnivorous adults
Authors: Ferreira Helena , Vasconcelos Marta , Gil Ana M. , Oliveira Beatriz , Varandas Elisete , Vilela Eugénia , Say Kimhuong , Silveira Joana , Pinto Elisabete 
Published: April 2023

AbstractAdopting eco‐friendly diets will demand the consumption of more plant‐based protein food sources such as legumes. However, assessing the impact of such a dietary shift on the dietary and nutritional intake of traditionally omnivorous populations is needed. The objective of this study was to assess the impact of substituting a traditional omnivorous‐based lunch for a vegetarian, legume‐based meal on the daily dietary and nutritional intake in a group of omnivorous adults in the city of Porto, Portugal. Nineteen, non‐vegetarian, healthy young adults consumed a vegetarian, legume‐based meal from Monday to Friday, for 8 consecutive weeks. Socio‐demographic data, health status, lifestyle‐related information and anthropometric parameters were recorded. Three‐day food records were used to collect food intake at baseline and week 8. European Food Safety Authority and World Health Organization reference values were used to assess nutritional inadequacies. Variables were described as medians (P25 and P75). Wilcoxon signed‐rank and Mann–Whitney tests were used for statistical comparisons. A p‐value of <0.05 was considered statistically significant. Participants consumed 38.0 (P25 = 35.0; P75 = 40.0) meals, resulting in an intake of 84.5 g (P25 = 74.9; P75 = 98.4) of cooked legumes per meal, meaning 11 subjects (57.9%) met the Portuguese guidelines for legume consumption (≥80 g/day of legumes). The current dietary intervention did not seem to aggravate the prevalence of nutritional inadequacies for the macro‐ and micronutrients tested, except for the case of vitamin B12 (52.6% [95% CI: 28.9–75.6] vs. 78.9% [95% CI: 54.4–94.0]). This could be linked to the reduction of dietary sources of this vitamin which is an expected consequence of vegetarian meals. Dietary changes towards grain legume‐based diets are desirable yet need to be carefully implemented to prevent exacerbating potential nutrient inadequacies, especially of vitamin B12.
The relationship between alarm fatigue and burnout among critical care nurses: A cross‐sectional study
Authors: Ding Shenglan , Huang Xiuhua , Sun Rong , Yang Lili , Yang Xiaorong , Li Xue , Liu Jianhua , Yang Hui , Zhou Hong , Huang Xiaoming , Su Fenghua , Shu Lingzhi , Zheng Xingli , Wang Xin 
Published: April 2023

AbstractBackgroundAlarm fatigue has significant negative impacts on nurses and patient safety. However, the relationship between alarm fatigue and burnout is still unclear.AimsThis study aimed to explore the relationship between alarm fatigue and burnout among critical care nurses.Study designA descriptive‐analytical cross‐sectional study design was used. Data were collected from five hospitals in mainland China between January 2022 and March 2022. A general information questionnaire, the Chinese version of the Intensive Care Unit Nurse Alarm Fatigue Questionnaire, and the Chinese version of the Maslach Burnout Inventory were used.ResultsA total of 236 critical care nurses were enrolled in this study. The mean score of alarm fatigue among critical care nurses was 21.11 ± 6.83. The results showed that critical care nurses experienced moderate alarm fatigue levels, and most nurses had moderate to high levels of burnout. The multiple linear regression analyses showed that alarm fatigue was independently associated with emotional exhaustion, depersonalization dimensions, and reduced personal accomplishment dimension.ConclusionsAlarm fatigue was associated with burnout among critical care nurses. Reducing critical care nurses' alarm fatigue may help to alleviate burnout.Relevance to clinical practiceManagers should provide comprehensive training for nurses and promote the application of artificial intelligence technology in alarm management to reduce alarm fatigue and improve burnout among critical care nurses.
Vital statistics, absolute abundance and preservation rate of Tyrannosaurus rex
Authors: Griebeler Eva M. 
Published: April 2023

AbstractI present a simulation model on vital statistics, absolute abundance (N, total number of individuals that ever lived) and preservation rate (p, minimum number of fossils known divided by N) of Tyrannosaurus rex. It is based on a published age‐structured population model that assumes a reptile or bird‐like reproduction for T. rex to estimate its age‐specific survival rates. My model applies input variables and equations from a recently published model on N and p. This model yielded 2.5 billion T. rex individuals (N) and one fossil per 80 million individuals (p). The average N values calculated by my model were at minimum 27.6% and p values at maximum 361.5% that of a previous model and uncertainties in all output variables were always larger in my model. The equation on output variable ‘population density’ introduced the largest uncertainty to N and p. The output variable ‘generation time’ differed the most between models, but for N and p, the huge size of the input area modelled and geological longevity minimized this difference. Unlike my model, the generation time as well as life expectancies, gross reproduction rates, and reproductive values of individuals calculated from the previous model all strongly contradicted our current understanding of the biology of T. rex and of other theropods. Their values also disagreed with those of large extant reptiles, birds and mammals. All of these shortcomings of the previous model favour the assessment of individual and population characteristics of T. rex and of other extinct species using my model.
The engineered CRISPR‐Mb2Cas12a variant enables sensitive and fast nucleic acid‐based pathogens diagnostics in the field
Authors: Jiao Jian , Liu Yiqi , Yang Mengli , Zheng Jingcheng , Liu Chonghuai , Ye Wenxiu , Song Shangwei , Bai Tuanhui , Song Chunhui , Wang Miaomiao , Shi Jiangli , Wan Ran , Zhang Kunxi , Hao Pengbo , Feng Jiancan , Zheng Xianbo 
Published: April 2023

SummaryExisting CRISPR/Cas12a‐based diagnostic platforms offer accurate and vigorous monitoring of nucleic acid targets, but have the potential to be further optimized for more efficient detection. Here, we profiled 16 Cas12a orthologs, focusing on their trans‐cleavage activity and their potential as diagnostic enzymes. We observed the Mb2Cas12a has more robust trans‐cleavage activity than other orthologs, especially at lower temperatures. An engineered Mb2Cas12a‐RRVRR variant presented robust trans‐cleavage activity and looser PAM constraints. Moreover, we found the existing one‐pot assay, which simultaneously performed Recombinase Polymerase Amplification (RPA) and Cas12a reaction in one system, resulted in the loss of single‐base discrimination during diagnosis. Therefore, we designed a reaction vessel that physically separated the RPA and Cas12a steps while maintaining a closed system. This isolated but closed system made diagnostics more sensitive and specific and effectively prevented contamination. This shelved Mb2Cas12a‐RRVRR variant‐mediated assay detected various targets in less than 15 min and exhibited equal or greater sensitivity than qPCR when detecting bacterial pathogens, plant RNA viruses and genetically modified crops. Overall, our findings further improved the efficiency of the current CRISPR‐based diagnostic system and undoubtedly have great potential for highly sensitive and specific detection of multiple sample types.
Influence of cannabis use on incidence of psychosis in people at clinical high risk
Authors: Chester Lucy A. , Valmaggia Lucia R. , Kempton Matthew J. , Chesney Edward , Oliver Dominic , Hedges Emily P. , Klatsa Elise , Stahl Daniel , van der Gaag Mark , de Haan Lieuwe , Nelson Barnaby , McGorry Patrick , Amminger G. Paul , Riecher‐Rössler Anita , Studerus Erich , Bressan Rodrigo , Barrantes‐Vidal Neus , Krebs Marie‐Odile , Glenthøj Birte , Nordentoft Merete , Ruhrmann Stephan , Sachs Gabriele , McGuire Philip ,   for the EU‐GEI High Risk Study Group
Published: April 2023

AimsEvidence for case–control studies suggests that cannabis use is a risk factor for the development of psychosis. However, there have been limited prospective studies and the direction of this association remains controversial. The primary aim of the present study was to examine the association between cannabis use and the incidence of psychotic disorders in people at clinical high risk of psychosis. Secondary aims were to assess associations between cannabis use and the persistence of psychotic symptoms, and with functional outcome.MethodsCurrent and previous cannabis use were assessed in individuals at clinical high risk of psychosis (n = 334) and healthy controls (n = 67), using a modified version of the Cannabis Experience Questionnaire. Participants were assessed at baseline and followed up for 2 years. Transition to psychosis and persistence of psychotic symptoms were assessed using the Comprehensive Assessment of At‐Risk Mental States criteria. Level of functioning at follow up was assessed using the Global Assessment of Functioning disability scale.ResultsDuring follow up, 16.2% of the clinical high‐risk sample developed psychosis. Of those who did not become psychotic, 51.4% had persistent symptoms and 48.6% were in remission. There was no significant association between any measure of cannabis use at baseline and either transition to psychosis, the persistence of symptoms, or functional outcome.ConclusionsThese findings contrast with epidemiological data that suggest that cannabis use increases the risk of psychotic disorder.