bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Role of Magnesium Levels in the Progression of Contrast-Induced Nephropathy in Patients With STEMI Undergoing Primary PCI
Authors: Demirtola Ayşe İrem , Mammadli Anar , Çiçek Gökhan 
Published: January 2025

Contrast-induced nephropathy (CIN) poses a significant risk following primary percutaneous coronary intervention (pPCI) in patients with ST-Elevation Myocardial Infarction (STEMI). Magnesium (Mg²⁺) deficiency has been associated with renal dysfunction and cardiovascular diseases, yet its role in CIN development remains unclear. This study represents the first investigation exploring the relationship between Mg²⁺ levels and CIN in this context. We conducted a retrospective study involving 2306 consecutive STEMI patients undergoing pPCI. Serum Mg²⁺ levels were measured on admission. Logistic regression and Receiver Operating Characteristic (ROC) analysis were employed to assess the association between Mg²⁺ levels and CIN development. Of the enrolled patients, 691 (30%) developed CIN post-pPCI. Mg²⁺ levels were significantly lower in the CIN group ( P < .001). Multivariate analysis identified Mg²⁺ <2.03 mg/dL, age >68 years, left ventricular Ejection Fraction (EF) <49%, and post-procedure Thrombolysis In Myocardial Infarction (TIMI) flow grade <2 as independent predictors of CIN. ROC analysis revealed an Mg²⁺ cutoff of 2.03 mg/dL, Area Under the Curve (AUC): 0.711, sensitivity: 69%, specificity: 68%). Our study demonstrates a significant correlation between low Mg²⁺ levels and CIN in STEMI patients undergoing pPCI, highlighting Mg²⁺ <2.03 mg/dL as an independent risk factor for CIN.
Machine learning-based sales forecasting during crises: Evidence from a Turkish women's clothing retailer
Authors: Kizgin Kiymet Tabak , Alp Selcuk , Aydin Nezir , Yu Hao 
Published: January 2025

Background Retail involves directly delivering goods and services to end consumers. Natural disasters and epidemics/pandemics have significant potential to disrupt supply chains, leading to shortages, forecasting errors, price increases, and substantial financial strains on retailers. The COVID-19 pandemic highlighted the need for retail sectors to prepare for crisis impacts on sales forecasts by regularly assessing and adjusting sales volumes, consumer behavior, and forecasting models to adapt to changing conditions. Methods This study explores strategies for adapting sales forecasts and retail approaches in response to such crises. By employing different machine learning (ML) methods, we analyze consumer behavior changes and sales impacts across various product categories, including bottom wear, top wear, one piece, accessories, outwear, and shoes during the COVID-19 pandemic. Results The gradient boosting and CatBoost algorithms excelled in product groups with significant sales changes during the pandemic. The Multi-Layer Perceptron (MLP) algorithm performed well in low-volume categories like accessories and footwear. Meanwhile, MLP, LightGBM, and XGBoost were effective in medium-volume categories such as outerwear and underwear. Conclusion The findings highlight the efficacy of these models in adapting sales forecasts to crisis conditions, offering a practical approach to enhancing retail resilience against future disruptions. This study offers an effective approach for adapting sales forecasting to shifting consumer behaviors during crises.
Improving Gait Ability and Cognition Function through Action Observation Training in Elderly with Dementia
Authors: Kang Choel-Jin , Park Se-Hee , Son Sung-Min 
Published: January 2025

Objective This study aimed to investigate the effect of Action observation training (AOT) on gait ability and cognition in older individuals with dementia. Methods A total of 36 participants were randomly assigned to the experimental (n=18) or control (n=18) group. The 5-week intervention involved 45-min sessions. The participants engaged in general group exercises for 30 min. The experimental group watched a training video for 5 min, while the control group watched a scenic video. Subsequently, both groups underwent functional training for 10 min. All participants were assessed using a gait analyzer (G-walk), Dynamic Gait Index (DGI), timed up and go (TUG) test, and the Korean version of the Montreal Cognitive Assessment (MoCA-K) before and after the intervention. Results The two groups showed significant within-group changes in gait velocity, cadence, stride length, DGI, and MoCA-K scores (p<0.05). However, the TUG test showed a significant differences only in the experimental group (p<0.05). A significant difference was observed between the experimental and control groups regarding the changes in gait velocity, cadence, DGI, TUG test, and MoCA-K score after the intervention (p<0.05). Conclusions The study suggest that AOT is effective in improving the gait and cognitive abilities of older individuals with dementia.
Functional Independence and Elbow Strength in Tetraplegia: Analysis of Tendon Transfers
Authors: García-Rudolph Alejandro , Mendez José Manuel , Ledesma Lidia , Wright Mark Andrew , del Arco Alejandro , Dachs Frederic 
Published: January 2025

Background Over half of spinal cord injuries result in tetraplegia, profoundly impairing daily activities (ADLs). Objective To evaluate biceps-to-triceps (B-T) and deltoids-to-triceps (D-T) tendon transfers, comparing their impacts on elbow extension strength and ADL independence. Methods Retrospective review of tendon transfers performed between 2003 and 2023 at a neurorehabilitation center. Post-surgery muscle strength was assessed using the Medical Research Council (MRC) scale and ADL independence with the motor Functional Independence Measure (mFIM). We used ANOVA to identify post-surgery associations between MRC achieved scores and performance in ADLs. Results A total of 34 individuals (42 arms) underwent B-T or D-T surgeries, predominantly at C5 level (66.7%) with 69.0% classified as AIS A. Post-surgery, 81% of B-T and 76.2% of D-T achieved antigravity elbow extension (MRC 3–4), with mean MRC scores of 3.2 for both groups. The B-T group, older at surgery (39.9 vs. 27.8 years) and with shorter time since injury to surgery (2.3 vs. 5.0 years), showed significant post-surgery improvements in Self-care, Transfers, Locomotion, and total mFIM. In contrast, significant associations between MRC scores and mFIM outcomes in D-T transfers involved Self-care, Sphincter control, Transfers, and total mFIM. Conclusions MRC scores and ADLs were positively impacted by rehabilitation tendon transfers.
Identifying New Susceptibility Genes of Non-Syndromic Orofacial Cleft Based on Syndromes Accompanied With Craniosynostosis
Authors: Zhang Si-Di , Lin Yan-Song , Shi Bing , Jia Zhong-Lin 
Published: January 2025

Objectives Orofacial cleft (OC) can be classified into syndromic orofacial cleft (SOC) and non-syndromic orofacial cleft (NSOC), depending on whether there are other congenital deformities. Craniosynostosis, the premature closure of cranial sutures, is a common phenotype of SOC resulting in abnormal ossification of skull and brain development disorders. Its correlation with OC offers a promising approach to identify susceptibility genes for NSOC by examining causative genes of SOCs with craniosynostosis. Materials and Methods This study included 2556 patients with NSOC and 2255 normal controls from western Han Chinese with their genomic DNA samples. We selected 31 causative genes of 34 syndromes with both craniosynostosis and OC as candidate genes and performed quality control. Allelic and genotypic association analyses and haplotype analysis were performed to identify statistically significant single nucleotide polymorphisms (SNPs). Results In allelic association analysis performed with 1265 qualified SNPs in 20 genes, only rs2239936, located in MYH3 gene, was statistically associated with non-syndromic cleft lip only (NSCLO) ( P = 1.70×10−07, OR  =  1.33, 95%CI: 1.17-1.52) and non-syndromic cleft palate only (NSCPO) ( P = 6.43×10−05, OR  =  1.33, 95%CI: 1.16-1.52). The higher frequency of allele G in NSCPO suggesting that minor allele G at rs2239936 will result in an elevated risk of NSCPO. However, rs2239936 only exhibited a statistical association with NSCPO in genotypic association analysis ( P = 8.06×10−06) and haplotype analysis ( P = 1.43×10−05). Conclusion This study identified that allele G at rs2239936 in MYH3 gene was significantly associated with NSCPO as a risk factor and MYH3 was a new susceptibility gene for NSCPO in western Han Chinese population.
Assessing the knowledge of ChatGPT and Google Gemini in answering peripheral artery disease-related questions
Authors: Cetin Hakkı Kursat , Demir Tolga 
Published: January 2025

Introduction To assess and compare the knowledge of ChatGPT and Google Gemini in answering public-based and scientific questions about peripheral artery disease (PAD). Methods Frequently asked questions (FAQs) about PAD were generated by evaluating posts on social media, and the latest edition of the European Society of Cardiology (ESC) guideline was evaluated and recommendations about PAD were translated into questions. All questions were prepared in English and were asked to ChatGPT 4 and Google Gemini (formerly Google Bard) applications. The specialists assigned a Global Quality Score (GQS) for each response. Results Finally, 72 FAQs and 63 ESC guideline-based questions were identified. In total, 51 (70.8%) answers by ChatGPT for FAQs were categorized as GQS 5. Moreover, 44 (69.8%) ChatGPT answers to ESC guideline-based questions about PAD scored GQS 5. A total of 40 (55.6%) answers by Google Gemini for FAQs related with PAD obtained GQS 5. In addition, 50.8% (32 of 63) Google Gemini answers to ESC guideline-based questions were classified as GQS 5. Comparison of ChatGPT and Google Gemini with regards to GQS score revealed that both for FAQs about PAD, and ESC guideline-based scientific questions about PAD, ChatGPT gave more accurate and satisfactory answers ( p = 0.031 and p = 0.026). In contrast, response time was significantly shorter for Google Gemini for both FAQs and scientific questions about PAD ( p = 0.008 and p = 0.001). Conclusion Our findings revealed that both ChatGPT and Google Gemini had limited capacity to answer FAQs and scientific questions related with PDA, but accuracy and satisfactory rate of answers for both FAQs and scientific questions about PAD were significantly higher in favor of ChatGPT.
Ascending aortic replacement versus aortic root replacement in patients with type A aortic dissection involving the aortic root
Authors: Biancari Fausto , Gatti Giuseppe , Mäkikallio Timo , Juvonen Tatu , Mariscalco Giovanni , El-Dean Zein , Pettinari Matteo , Rodriguez Lega Javier , Perrotti Andrea , Onorati Francesco , Wisniewki Konrad , Demal Till , Kacer Petr , Perna Dario Di , Vendramin Igor , Rinaldi Mauro , Ferrante Luisa , Quintana Eduard , Buech Joscha , Radner Caroline , Fiore Antonio , Dell’Aquila Angelo M. , D’Errigo Paola , Rosato Stefano , Polvani Gianluca , Peterss Sven 
Published: January 2025

Background: Extensive surgical resection of the thoracic aorta in patients with type A aortic dissection (TAAD) is thought to reduce the risk of late aortic wall degeneration and the need for repeat aortic operations. Objectives: We evaluated the early and late outcomes after aortic root replacement and supracoronary ascending aortic replacement in patients with TAAD involving the aortic root. Design: Retrospective, multicenter cohort study. Methods: The outcomes after aortic root replacement and supracoronary ascending aortic replacement in patients with TAAD involving the aortic root, that is dissection flap located at least in one of the Valsava segments, were herein evaluated. In-hospital mortality, neurological complications, dialysis as well as 10-year repeat proximal aortic operation, and mortality were the outcomes of this study. Results: Supracoronary ascending aortic replacement was performed in 198 patients and aortic root replacement in 215 patients. During a mean follow-up of 4.0 ± 4.0 years, 19 patients underwent 22 repeat procedures on the aortic root and/or aortic valve. No operative death occurred after these reinterventions. The risk of proximal aortic reoperation was significantly lower in patients who underwent aortic root replacement (5.5% vs 12.9%, adjusted subdistributional hazard ratio (SHR) 0.085, 95% CI 0.022–0.329). Aortic root replacement was associated with higher rates of in-hospital (14.4% vs 12.1%, adjusted odds ratio 2.192, 95% CI 1.000–4.807) and 10-year mortality (44.5% vs 30.4%, adjusted hazard ratio 2.216, 95% CI 1.338–3.671). Postoperative neurological complications and dialysis rates were comparable in the study groups. Conclusion: Among patients with TAAD involving the aortic root, its replacement was associated with a significantly lower rate of repeat proximal aortic operation of any type compared to supracoronary aortic replacement. Still, aortic root replacement seems to be associated with an increased risk of mortality in these patients. ClinicalTrials.gov: NCT04831073 ( https://clinicaltrials.gov/study/NCT04831073 ).
Long-term Clinical Outcomes After Syndesmosis Fixation With K-wires in Ankle Fractures With Syndesmotic Instability
Authors: Vieira Cardoso Diogo , Pierobon Filippo , Lübbeke-Wolff Anne , Dubois-Ferrière Victor 
Published: January 2025

Background: Syndesmotic instability is a significant concern in the management of unstable ankle fractures, occurring in approximately 10% to 13% of these cases. Early recognition and stabilization of syndesmotic injuries are essential to ensure optimal long-term outcomes. Several techniques are currently in use, often involving complex procedure and/or costly devices. Our study presents a syndesmosis fixation technique using K-wires that is both simple and cost-effective. Methods: This is a retrospective single-center case series. Three hundred seventy-seven ankle fractures with intraoperative syndesmosis instability and subsequent syndesmosis fixation with a K-wire were treated between 2002 and 2012. Of the 377 patients, 51 died and we were able to obtain long-term questionnaire completions from 94 patients (29% of presumed living patients), with a mean follow-up of 10.6 ± 3.0 years. Results: The mean age was 46.6 ± 18.5 years; 42% were Danis-Weber type B and 58% type C fractures. Syndesmosis fixation failure was observed in 9 (2%) patients, and 5 (1%) patients had K-wire displacement without loss of syndesmosis reduction. The Manchester-Oxford Foot Questionnaire (MOXFQ) was obtained 10±3 years after surgery. The mean MOXFQ pain score was 25.9 ± 25.4, the mean functional score was 18 ± 24.8, and the mean social score was 13.7 ± 22.2. Conclusion: We report long-term (10.6 ± 3 years) functional outcomes using a validated patient-reported questionnaire in patients who underwent syndesmosis fixation with 2 K-wires for unstable ankle fractures. In the subset of patients we were able to find in follow-up, we found low rates of syndesmosis fixation failure, low pain scores, and excellent functional outcomes. The availability and low cost of these implants make this technique an accessible and cost-effective solution to consider for syndesmosis fixation. Level of Evidence: Level IV, retrospective case series.
Purine-rich element binding protein alpha: a DNA/RNA binding protein with multiple roles in cancers
Authors: Yu Shiyi , Jiang Chengyang , Yang Yawen , Cheng Fei , Liu Fangchen , Liu Chang , Gong Xue 
Published: January 2025

Abstract
Proteins that bind to DNA/RNA are typically evolutionarily conserved with multiple regulatory functions in transcription initiation, mRNA translation, stability of RNAs, and RNA splicing. Therefore, dysregulation of DNA/RNA binding proteins such as purine-rich element binding protein alpha (PURα) disrupts signaling transduction and often leads to human diseases including cancer. PURα was initially recognized as a tumor suppressor in acute myeloid leukemia (AML) and prostate cancer (PC). Most recently, several studies have revealed that PURα is dysregulated in multiple cancers, such as breast cancer (BC) and esophageal squamous cell carcinoma (ESCC). The oncogenic or tumor-suppressive functions of PURα are realized via regulating RNA/protein interaction, mRNA translation, formation of stress granules (SGs), and transcriptional regulation of several oncogenes and tumor suppressors. Although DNA/RNA binding proteins are hardly targeted, novel strategies have been applied to identify compounds targeting PURα and have demonstrated promising anti-tumor efficacy in the preclinical study. The present review summarizes the most recently discovered critical roles of PURα in various cancer types, providing an overview of the biomarker and therapeutic target potential of PURα for patients with cancer.
Patterns of psychiatric healthcare use during pandemic times among boys and girls with pre-existing diagnoses: a Norwegian nationwide primary and specialist healthcare registry study
Authors: Lund Ingunn Olea , Jensen Pia , Madsen Christian , Hauge Lars Johan , Havdahl Alexandra , Reneflot Anne , Brandlistuen Ragnhild , Ask Helga 
Published: January 2025

Abstract

Background
The COVID-19 pandemic introduced complexities that were likely more demanding for some groups, such as children and adolescents, and especially those with pre-existing mental health diagnoses. This study examines long-term patterns of psychiatric healthcare use among this vulnerable group, providing insights into shifts in psychiatric healthcare use during a global health crisis.

Methods
We use data from the primary and specialist healthcare registries available from the Norwegian emergency preparedness register for COVID-19 (Beredt C19) to estimate patterns of psychiatric healthcare use. The data spans 2017 to 2022, covering children and adolescents aged 6–19. We identified young people with recent diagnoses of mental health conditions and compared weekly consultation volumes before and during the pandemic for mental health conditions overall and the following diagnostic or symptom categories separately: anxiety/depression and Attention-Deficit Hyperactivity Disorders (ADHD). Analyses were stratified by gender.

Results
There was a consistent trend of lower-than-predicted weekly healthcare consultations among young people with pre-existing mental health diagnoses in both primary and specialist healthcare during the pandemic. The reduction was more pronounced in later follow-up periods. The study highlights gender disparities, with boys experiencing more notable declines in healthcare consultations, especially in specialist care. Additionally, the time trends varied across different diagnostic groups. While consultations for anxiety/depression were consistently below the predicted levels, declines in ADHD occurred later in the pandemic. The data suggests an overall decline in healthcare use rather than a shift between sectors.

Conclusion
The findings offer insights into healthcare use during pandemic times among children and adolescents with pre-existing mental health diagnoses. The study underscores the importance of continuous monitoring and support for this group, ensuring accessible and responsive healthcare during public health emergencies.
Factors associated with lung cancer among firefighters: a systematic literature review
Authors: Kang Augustine W. , Lui Natalie S. 
Published: January 2025

Abstract
This short review addresses the pressing issue of lung cancer among firefighters, a population facing unique occupational hazards such as smoke inhalation and asbestos exposure. With lung cancer being a leading global cause of death, the study emphasizes the disproportionate burden on firefighters. Notably, wildfire smoke, containing carcinogenic elements, poses a rising significant threat to firefighters’ respiratory health. Despite evidence linking firefighting to increased lung cancer risk, few studies have explored the underlying mechanisms. This study conducts a comprehensive review employing PRISMA guidelines to synthesize existing literature from 1972 to 2022. We discuss the association between age, race, and time spent fighting fires with lung cancer development. Our review also underscores the scarcity of studies investigating specific carcinogens and their role in firefighters’ lung cancer risk, emphasizing the need for more targeted research. The study advocates for improved methodology, suggesting the use of individual-level exposure metrics like “fire-hours” to enhance causal inference. Despite limitations in current literature, the findings stress the urgency of understanding the intricacies of lung cancer development among firefighters and call for further research to inform preventive measures and potential screening protocols.
Implementation of a sexual health clinic in an oncology setting: patient and provider perspectives
Authors: Matthew Andrew G. , Incze Taylor , Stragapede Elisa , Guirguis Steven , Neil-Sztramko Sarah E. , Elterman Dean S. 
Published: January 2025

Abstract

Background
Sexual dysfunction is prevalent among cancer survivors, significantly impacting patient and partner quality of life. Despite this, sexual health clinics (SHCs) remain rare in cancer centres across Canada. An innovative clinic was developed at Princess Margaret Cancer Centre in Toronto, Canada to address this significant gap in survivorship care. This study examines factors affecting the provision of sexual healthcare and the implementation of a sexual health clinic within a large urban centre.

Methods
The Quality Implementation Framework was used to explicate patient and provider experience and identify barriers and facilitators to integrating sexual healthcare into routine cancer care workflows. Healthcare providers and patients representing selected cancer types (prostate, cervical, ovarian, testicular, bladder, kidney, and head and neck cancer) participated in semi-structured interviews. Interviews were transcribed and analyzed using the Framework qualitative analysis protocol.

Results
The analysis identified three organizing domains and ten themes that describe the unique aspects of the sexual healthcare experience and critical factors for sexual health implementation. Both patients and providers described a lack of sexual health support in the oncology setting and emphasized the need for comprehensive and personalized care. Limitations of current care provision included mutual silence between patients and providers due to discomfort in discussing sexual issues, insufficient provider confidence in delivering optimal sexual healthcare, and constraints related to space and time. Key Factors for implementing a sexual health clinic in oncology emphasized the importance of having a dedicated clinic, flexibility in service delivery, proactive patient engagement, and ongoing staff education.

Conclusions
Findings highlight significant challenges in addressing sexual health in an oncology setting, underscoring the need for specialized sexual health clinics that are integrated with, but distinct from, routine oncology care. This study further emphasizes the need for incorporating sexual healthcare in survivorship programs as well as the necessity of conducting thorough implementation research, involving multiple stakeholders, prior to launching new programs.