bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dysregulated serum lipid profile and atherosclerosis in untreated female TA patients: a PSM analysis
Authors: Zang Qijuan , Wang Jing , Li Fei , Ju Yalin , Luo Jing , Liu Wenbin , Ding Tianlong , He Lan , Mo Lingfei 
Published: June 2023

Abstract
Objective
Recent studies indicate that dyslipidemia could be a critical risk factor for cardiovascular disease in Takayasu arteritis (TA), but the relationship between dyslipidemia and the disease activity of TA itself is unclear.
Methods
To better understand the connection between serum lipid profiles and disease activity in TA patients, this study assessed the presence of dyslipidemia and atherosclerosis in untreated female patients. Fifty untreated female patients with Takayasu arteritis (median age 30 years) and 98 age- and BMI-matched healthy controls were enrolled. The lipid profile (TC, TG, HDL-C, LDL-C, ApoA1, ApoB, ApoE, LPa), inflammatory markers (CRP, ESR) and carotid atherosclerotic plaque frequency were evaluated.
Results
The levels of TG, nonHDL-C/HDL-C in TA patients were significantly higher than those in the control group, while the levels of TC, HDL-c, and ApoA1 were significantly lower than those in the control group. Spearman correlation analysis showed that CRP was positively correlated with ApoB, nonHDL-C/HDL-C, while negatively correlated with TG, HDL-c, and ApoA1. Besides, ESR was positively correlated with LDL-C, ApoB, nonHDL-C, nonHDL-C/HDL-C, but negatively correlated with ApoA1. Carotid atherosclerotic plaque was found in 8 (14.3%) patients. Multivariate regression analysis showed that the presence of atherosclerotic plaque was only related to age, but not inflammatory markers nor lipoproteins.
Conclusions
Overall, this study implies that untreated female TA patients have an obvious dysregulated serum lipid profile. Moreover, the disease activity of TA itself may be a risk factor for dyslipidemia, supporting the hypothesis that young TA patients may also have a higher risk of cardiovascular disease.
Integration of Multiple Fundamental Instrumental Analyses to Understand the Key Factors for Enhancing Enzymatic Saccharification of Oil Palm (Elaeis guineensis) Empty Fruit Bunch by Aqueous Pretreatments
Authors: Hemashini Tannimalay , Lee Chee Keong , Goh Choon Fu , Ismayati Maya , H’ng Yin Ying , Leh Cheu Peng 
Published: June 2023

Abstract
Simple aqueous pretreatments were performed on oil palm empty fruit bunch (OPEFB) to enhance its enzymatic digestibility by the cellulolytic enzyme. Autohydrolysis, acid and alkaline pretreatments were conducted at appropriate temperatures for 45 minutes with a solid: liquor ratio of 1:7. The refined pretreated OPEFBs were enzymatically saccharified at a fixed condition of 50°C, pH 4.8 for 48 hours. Besides chemical composition analysis, various changes in biomass during pretreatments were also evaluated using the fundamental instrumental analyses namely HPLC, FTIR, SEM, XRD, Py-GCMS and XPS. Autohydrolysed biomass achieved the maximum (> 99.9%) enzymatic saccharification/total glucose yield (TGY), attributed to 77% hemicellulose and 24% lignin removals, with only 16% cellulose loss. The crystallinity index was significantly correlated with TGY, but morphological analysis, S/G ratio of lignin, and O/C ratio were irrelevant. The key TGY-enhancing factors of pretreatment were unable to be identified by any single instrumental analysis. Determining the chemical composition of the biomass remains the primary fundamental analysis to understand the requirement for improving enzymatic yield.
FACS-mediated selection enhances growth and carotenoid production in subpopulations of Phaeodactylum tricornutum
Authors: Miller Sean Macdonald , Herdean Andrei , Gupta Vishal , Signal Brandon , Abbriano Raffaela M. , Ralph Peter J. , Pernice Mathieu 
Published: June 2023

AbstractFluorescence-Activated Cell Sorting (FACS) is a powerful method with many applications in microalgal research, especially for screening and selection of cells with improved phenotypes. However, the technology requires further investigation to determine the phenotypic stability of sorted populations.Phaeodactylum tricornutumcells were sorted using FACS with excitation/emission parameters targeted towards favouring the industrially-relevant carotenoid fucoxanthin. The resulting cultures showed significantly higher growth rate (1.10 ×), biomass (1.30 ×), chlorophyllalevels (1.22 ×) and fucoxanthin productivity (1.41 ×) relative to the wild-type strain. RNA-seq was used to elucidate the underlying molecular-level regulatory changes associated with these traits, and represents the first study do so on FACS-sorted microalgal cultures. Transcriptome analysis corroborated evidence of increased chlorophyllaand fucoxanthin, showing enrichment for the genes/pathways for tetrapyrrole biosynthesis and for suites of genes directly related to photosynthesis. Only three genes were upregulated in the MEP (non-mevalonate) pathway to carotenoid biosynthesis pathway, suggesting either a strong influence ofIDI,CRTISO5andZEP1on fucoxanthin biosynthesis or a post-transcriptional or post-translational mechanism for the observed increase in fucoxanthin content.
Barriers and facilitators to the HPV vaccine: a multicenter qualitative study of French general practitioners
Authors: TRON Arthur , SCHLEGEL Vincent , PINOT Juliette , BRUEL Sébastien , ECOLLAN Marie , BEL Josselin LE , ROSSIGNOL Louise , Gauchet Aurélie , Gagneux-Brunon Amandine , Mueller Judith , BANASZUK Anne-Sophie , THILLY Nathalie , GILBERG Serge , PARTOUCHE Henri 
Published: June 2023

Abstract
Background: In France, human papillomavirus (HPV) vaccination coverage is low, with 30.7% of 17-year-old girls having received a complete HPV vaccination schedule in 2020.
Aim: To determine the perspective and behaviors of general practitioners (GPs) regarding HPV vaccination with their patients and if a reluctance is observed.
Design and Setting: A qualitative study based on semi-directed individual interviews was conducted between December 2019 and December 2020. A representative sample of GPs with various profiles were included in 4 French regions.
Method: A purposive sampling was used and interviews were continued until data saturation was reached. The analysis was based on the grounded theory.
Results: Twenty-six GPs aged 29-66 years were interviewed. The measures taken by the French health authorities (lowering the target age, reimbursing the vaccine, extending the target population to boys) were perceived as facilitators. The reported barriers were organizational, due to low attendance of adolescents, and relational, mainly due to parental vaccine hesitancy. Physicians had to deal with fears about the perceived risks and concerns about sexuality conveyed by HPV vaccination and linked to the socio-cultural characteristics of the families. Physicians developed strategies, including scientific knowledge mobilization, empowerment of families by promoting health through prevention, repetition of the vaccination proposals, personal experience and relationship. Different practices were identified according to three GP typologies: effective, convinced but unpersuasive, and reluctant physicians.
Conclusion: Based on these results, specific interventions, including communication techniques, especially for hesitant or unpersuasive physicians, are needed to enable GPs to become more effective.
A Qualitative Examination of Primary Care Team’s Participation in the Distribution of the COVID-19 Vaccination
Authors: Ashcroft Rachelle , Donnelly Catherine , Lam Simon , Sheffield Peter , Hamilton Bryn , Kemp Connor , Adamson Keith , Brown Judy Belle 
Published: June 2023

Abstract
Background
Primary health care (PHC) has historically led and implemented successful immunization programs, driven by strong relationships with patients and communities. During the COVID-19 pandemic, Canada began its vaccination strategy with mass immunizations that later included local efforts with PHC providers. This rollout approach has been criticized for not effectively utilizing the expertise of PHC to support vaccination distribution. This study seeks to understand how PHC contributed to the different phases of the COVID-19 vaccination rollouts in Ontario, Canada’s most populous province.
Methods
We conducted a descriptive qualitative study with focus groups consisting of PHC providers, administrators, and staff in Ontario. Eight focus groups were held with 39 participants representing geographic diversity across the six Ontario Health regions. Participants reflected a diverse range of clinical, administrative, and leadership roles. Each focus group was audio-recorded and transcribed with transcriptions analyzed using thematic analysis.
Results
With respect to understanding PHC teams’ participation in the different phases of the COVID-19 vaccination rollouts, we identified five themes: i) supporting long-term care, ii) providing leadership in mass vaccinations, iii) integrating vaccinations in PHC practice sites, iv) reaching those in need through outreach activities; and v) PHC’s contributions being under-recognized.
Conclusions
PHC was instrumental in supporting COVID-19 vaccinations in Ontario, Canada. The versatility of primary care enabled participation across all phases of Ontario’s COVID-19 vaccine rollout which enabled access to vaccines for the most vulnerable populations and communities. The flexibility and adaptability of PHC allowed teams to participate in both large-scale and small-scale vaccination efforts.
Factors associated with eye care seeking behaviors in rural Malawi: A cross-sectional study
Authors: Mbemba Erasmo , Soko Margret , Mkandawire John , Phiri Lael , Chisiza Rose , Nyirenda Loynah , Jacobs Emmanuel , Jere Sandress , Mbakaya Balwani 
Published: June 2023

Abstract
Background
Eye care-seeking behavior plays a critical role in the prevention, diagnosis, and treatment of various eye conditions, enabling individuals to maintain good visual health and overall well-being. The study focused on three objectives: knowledge, attitudes, and practices regarding eye care.
Methods
The study employed quantitative methods approach, utilizing a cross-sectional study design. A total of 391 participants took part in the study. Multistage and systematic random sampling techniques were used to select participants. The data was collected using questionnaires and analyzed using SPSS version 24. The study was conducted around the Livingstonia catchment area, a typical rural setting of Malawi
Results
The results showed knowledge gaps on eye care, for instance; participants were asked about the causes of decreased vision and blindness, and they responded that excess sunlight (67%, n=262), and eye injury (84%, n=328) were not part of the causes of decreased vision and blindness. On practices, the results indicated that (81%, n=317) never got their eyes checked and facial cleanliness (59%, n=231) was the major way of protecting their eyes. On attitudes, the participants said that distance (61%, n=239) and cost of service (72%, n=282) highly affected their access to eye care services.
Conclusion
The study uncovered important factors that contributed to the low uptake of eye care services.
Therefore, we recommend that outreach clinics, subsidizing eye care services through government service level agreements, and community awareness campaigns should be introduced and intensified.
WITHDRAWN: Implant stability changes in dental implants installed by osseodensification and conventional methods: A randomized controlled study
Authors: Dayeh B.D.S Noor A. , B.D.S. F.I.B.M.S. Professor Salwan Y Bede 
Published: June 2023

Abstract
Purpose In this study, the osseodensification (OD) drilling technique was used to assess the impact of implant site preparation on implant stability changes during the osseous healing period, insertion torque (IT), and preparation time.Methods In this randomized controlled clinical study, a total of 20 patients received 40 dental implants (DI), which were divided into two groups at random: the first group (the study group), which received the implants using the OD drilling technique, and the second group (the control group), which received the implants using the conventional drilling technique. Prior to surgery, bone density was assessed by CBCT. The Osstell implant stability quotient (ISQ) was used to measure implant stability immediately following implant insertion as well as 6 and 12 weeks later.Results There was no statistically significant difference in primary stability between the groups (P-value 0.216). In contrast, at 6 weeks and 12 weeks postoperatively, the control group showed higher ISQ values (P-values 0.002 and 0.005, respectively). There was no significant difference in the (IT) between the groups (P-value 0.627). The preparation time was significantly longer in the study group compared to the control group (P-value 0.0001).Conclusion The OD drilling technique did not show a more favorable outcome regarding the implant stability changes, IT, and preparation time over that of the conventional approach and resulted in a significant drop in stability after 6 weeks postoperatively, making OD use for early loading questionable.
A new hope for targeted therapy of ischemia-reperfusion injury: E2F2, an important transcription factor in H/R process
Authors: 赵 元彬 , Qin Hao , Yang Ren-qiang 
Published: June 2023

Abstract
Background At present, there is still no effective treatment for ischemia-reperfusion injury (IRI), and gene targeted drug therapy is a new idea. In this study, the differential expression of multiple genes and transcription factors during HUVECs ischemia-reperfusion was analyzed by bioinformatics methods, and the target genes were predicted and verified by q-PCR. Therefore, the mechanism by which E2F2 may participate in the development of ischemia-reperfusion injury by regulating differentiation factor 1 (ID1) was explored.Results The mRNA expression profile dataset GSE193047 was acquired from the GEO database. Heat map and volcano plot showed that a total of 270 genes were differentially expressed, of which 150 genes were up-regulated and 120 genes were down-regulated. The GSEA of transcription factor indicated the significant enrichment of E2F2. Then the online prediction websites CHIP BASE and CISTROME were used to predict the target genes of E2F2. Considering the low expression of E2F2 in dataset GSE193047, down-regulated target genes of E2F2 in this dataset were identified. By constructing the target gene network, it was found that the target gene ID1 may be regulated by E2F2, and the significant differences were verified by q-PCR.Conclusions The constructed E2F2-target gene regulatory network was analyzed by bioinformatics methods, which showed that E2F2 may participate in the development of ischemia-reperfusion injury by regulating ID1. This study revealed a new mechanism involved in IRI, which may serve as a potential predictive biomarker and therapeutic target. Further study is needed to investigate the role of E2F2/ ID1 pathway in the occurrence and development of ischemia-reperfusion injury.
Too Much Gravity: Delusional Intensification of G Force
Authors: Birwatkar Drushti , Kalita Shweta , Mehdiratta Nikita , Hirsch Alan 
Published: June 2023

Abstract
Introduction: A misperception of intensified gravitational forces as a psychotropic effect has not heretofore been described.
Methods: Case Study: A 37-year-old right-handed female with a history of hypertension, diabetes mellitus type 2, and schizoaffective disorder with bipolar subtype presented with presence hallucinations. For an epoch of 2 days, she experienced the sensation that something was "pressing down on her" and that gravity was too strong. She argued that gravity was too strong rather than feeling weak. The patient received carbamazepine 200 mg QHS, haloperidol 5 mg BID, baclofen 5 mg QHS, and chlorpromazine 50 mg PO BID at during the episode.
Results: Physical Examination: Diffuse thyroid enlargement. Neurological Examination: Mental Status Examination: The patient is awake with poor hygiene and eye contact. Hyperverbal, grandiose with expansive affect, poor insight, and judgment. Cranial Nerve (CN) examination: CN I: Alcohol Sniff Test: 8. CN II: Visual acuity with correction 20/20 OD, 20/25 OS. Motor Examination: Mild left pronator drift. Cerebellar Examination: Finger-to-nose dysmetria bilaterally. Reflexes: 3+ bilateral brachioradialis and biceps, 1+ left triceps, and absent reflexes in both lower extremities. Bilateral positive Hoffman's reflexes. The Patient Health Questionnaire 9: 7.
Discussion: The psychic slowing of schizoaffective disorder may lead to a more significant effort to contract muscles, thus reducing muscle contraction and strength, with an overwhelmingly pronounced perception of weight and gravity. Psychotropic medications may have acted to cause dysfunction in muscle initiation and preparation of muscle firing, causing a reduction of contraction of muscle spindles and reduced muscle tension, thus reducing weight perception. Peradventure, psychotropics may induce muscle stiffness, increasing weight perception. Moreover, drug-induced Parkinson's symptoms have not induced weakness but rather a lag or delay between the motor command and muscle contraction, which was perceived as weakness and thus increased perception of gravitational force. Psychotropic drug evaluation would benefit those with a distorted perception of external objects and forces, especially those who do not complain of weakness or exhaustion.
Who Leads? Who Follows? Exploring Agenda Setting by Media, Social Bots and Public in the Discussion of 2022 South Korea Presidential Election
Authors: Zhang Menghan , Chen Ze , Liu Xinyan , Liu Jun 
Published: June 2023

Abstract
Social media not only changes the traditional communication environment, but also brings new changes to agenda setting. The main body of agenda setting has shifted from the traditional media to the politicians, political parties and grassroots people. With the increasing use of social bots in public opinion manipulation and political election interference, whether they can participate in or influence agenda setting has become an urgent concern. So far, there is less literature focusing on engagement in agenda-setting for social bots. This paper studies the social media discussion content of the South Korean presidential election, determines the participation of social bots, and explores the connection between media agenda, bot agenda and public agenda from the perspective of agenda setting. The study found that while the main agendas of media, social bots and the public are not the same, their agendas are relevant. In addition, the media agenda is not timely ahead of the bot agenda and the public agenda, and the time order only appears between the social bots and the public.
Egocentric Activity Recognition Using Two-Stage Decision Fusion
Authors: Arabacı Mehmet Ali , Surer Elif , Temizel Alptekin 
Published: June 2023

Abstract
The usage of wearable devices in daily life has grown rapidly with the advancements in sensor technologies. These devices primarily rely on optical sensors to capture videos from an egocentric perspective, known as First Person Vision (FPV). FPV videos possess distinct characteristics compared to third-person videos, such as significant ego-motions and frequent scene changes. Consequently, vision-based methods designed for third-person videos, where the camera is positioned away from events and actors, cannot be directly applied to egocentric videos. Thus, it is essential to propose new approaches capable of effectively analyzing egocentric videos and accurately integrating inputs from various sensors to address specific tasks. In this study, we propose an audio-visual decision fusion framework for egocentric activity recognition. Our framework leverages deep features and incorporates a two-stage decision fusion mechanism. In addition, we introduce a new publicly available dataset, Egocentric Outdoor Activity Dataset (EOAD), which comprises 30 different egocentric activities and 1392 video clips with audio. Experimental evaluations show that combining audio and visual information enhances activity recognition performance, yielding promising results compared to using a single modality or equally weighted decisions from multiple modalities.
Post-operative C-Reactive Protein trend may lead to early diagnosis of anastomotic leak after ileocolic resection in Crohn’s disease
Authors: Solé Michael , Albuisson Eliane , Chanty Hervé , Ayav Ahmet , Germain Adeline 
Published: June 2023

Abstract
Purpose: C-Reactive Protein is a useful biomarker commonly used during post-operative care for patients having undergone colorectal cancer surgery and aid clinicians in the early detection of anastomotic leak. We aim to analyse this marker’s trend among patients with Crohn’s disease having undergone an ileocolic resection with primary anastomosis to detect an anastomotic leak.
Methods: We included in this retrospective study all patients having undergone ileocolic resection with primary anastomosis. C-Reactive Protein was measured during the first 48 hours and repeated 48 hours thereafter. Variation between these two measurements was analysed. The main endpoint was the discovery or not of an anastomotic leak by Computed Tomography imaging in relation to the variation of the C-Reactive Protein between the two measurements. Secondary endpoint was the discovery of an anastomotic leak needing an immediate operative approach.
Results: 59 patients were included. Eight patients (13.5%) suffered from an anastomotic leak. Four (6.7%) patients needed urgent surgical care. The variation of the C-Reactive Protein between the two measurements with a cut-off of 1.37% allowed for a sensitivity of 87.5% and a specificity of 72.5%. Positive predictive value was 33.3% and negative predictive value was 97.4%.
With regards to the secondary endpoint, a cut-off of 9.08%, sensitivity was 71% and specificity 71%. Positive predictive value was 15.8% and negative predictive value was 97.5%.
Conclusion: Stagnation or positive increase of C-Reactive Protein level at 48 hours during postoperative care should encourage clinicians to consider further investigations regarding a possible anastomotic leak.
Risk Factors for Dural Tears in Spinal Surgery: A Prospective Multicenter Registry Study of 1,698 Cases
Authors: Hirahata Masahiro , Fujita Muneyoshi , Inui Takahiro , Ishii Keisuke , Takekawa Tatsuhisa , Iwai Hiroki , Murata Yasuaki , Yamada Kazuaki , Shiboi Ryutaro , Yonezawa Keisuke , Iwahori Tomoyuki , Iimuro Satoshi , Fujita Retsu , Kawano Hirotaka , Kitagawa Tomoaki 
Published: June 2023

Abstract
PurposeTo clarify the predictors of dural tear (DT) through a prospective cohort study with a low dropout rate.
Methods In this prospective multicenter cohort study in Japan, a registry was established to collect information about patients undergoing spinal surgery between July 1, 2020 and June 30, 2021 at 10 hospitals. Clinical features, laboratory data, and operative factors were collected from the database. Risk factors were analyzed by comparing DT and non-DT groups.
ResultsA total of 1,698 patients were enrolled. There were 74 cases with unintended DTs (4.4%; DT group) and 1624 cases without DTs (non-DT group). Multivariate analysis revealed that age, rheumatoid arthritis, non-attending surgeon as the operator, and creatinine kinase were significant risk factors for DTs.
Conclusions The incidence of DTs in spinal surgery was 4.4%, and identified risk factors were age, rheumatoid arthritis, non-attending surgeon as the operator, and creatinine kinase.