bluuebunny/crossref_metadata_2025_split huggingface dataset:
Putting ChatGPT’s Medical Advice to the (Turing) Test: Survey Study
Authors: Nov Oded , Singh Nina , Mann Devin 
Published: June 2023

Background
Chatbots are being piloted to draft responses to patient questions, but patients’ ability to distinguish between provider and chatbot responses and patients’ trust in chatbots’ functions are not well established.

Objective
This study aimed to assess the feasibility of using ChatGPT (Chat Generative Pre-trained Transformer) or a similar artificial intelligence–based chatbot for patient-provider communication.

Methods
A survey study was conducted in January 2023. Ten representative, nonadministrative patient-provider interactions were extracted from the electronic health record. Patients’ questions were entered into ChatGPT with a request for the chatbot to respond using approximately the same word count as the human provider’s response. In the survey, each patient question was followed by a provider- or ChatGPT-generated response. Participants were informed that 5 responses were provider generated and 5 were chatbot generated. Participants were asked—and incentivized financially—to correctly identify the response source. Participants were also asked about their trust in chatbots’ functions in patient-provider communication, using a Likert scale from 1-5.

Results
A US-representative sample of 430 study participants aged 18 and older were recruited on Prolific, a crowdsourcing platform for academic studies. In all, 426 participants filled out the full survey. After removing participants who spent less than 3 minutes on the survey, 392 respondents remained. Overall, 53.3% (209/392) of respondents analyzed were women, and the average age was 47.1 (range 18-91) years. The correct classification of responses ranged between 49% (192/392) to 85.7% (336/392) for different questions. On average, chatbot responses were identified correctly in 65.5% (1284/1960) of the cases, and human provider responses were identified correctly in 65.1% (1276/1960) of the cases. On average, responses toward patients’ trust in chatbots’ functions were weakly positive (mean Likert score 3.4 out of 5), with lower trust as the health-related complexity of the task in the questions increased.

Conclusions
ChatGPT responses to patient questions were weakly distinguishable from provider responses. Laypeople appear to trust the use of chatbots to answer lower-risk health questions. It is important to continue studying patient-chatbot interaction as chatbots move from administrative to more clinical roles in health care.
Ultrasound-Assisted Continence Care Support in an Inpatient Care Setting: Protocol for a Pilot Implementation Study
Authors: Hofstetter Sebastian , Ritter-Herschbach Madeleine , Behr Dominik , Jahn Patrick 
Published: June 2023

Background
This nonrandomized exploratory intervention and feasibility study examines how digital assistive technology (DAT), comprising a DFree ultrasound sensor, affects nursing care for continence support and evaluates nurses’ willingness to incorporate DAT into the planning and practical implementation of care processes.

Objective
The relief provided by DFree in the clinical care setting and the extent to which it supports nursing care for activities of daily living pertaining to “micturition” is unclear. DAT DFree is expected to reduce nurses’ workload in clinical continence-care settings and was designed as a human-technology interaction that ensures a high level of usability for the subjects (ie, the nurses) and increases user acceptance by at least one level (eg, from average to slightly above average) during the study.

Methods
Approximately 45 nurses from neurology, neurosurgery, and geriatric medicine clinics and polyclinics at the University Medicine Halle will be included in the 90-day (3-month) intervention on-site in the respective wards. After the wards are equipped with digital technologies, the participating nurses will be trained to use DFree and will be able to select DFree as a possible patient-care resource if the anamnesis includes bladder dysfunction among only patients who are willing to participate. The willingness of nurse participants to use DFree in planning their care process will be assessed using the Technology Usage Inventory at 3 measurement points. The primary target values include the results of the multidimensional Technology Usage Inventory assessment that will be processed using descriptive statistics. Ten participating nurses will be invited to conduct extensive guided interviews that are intended to provide information about the device’s usefulness and feasibility in the specific field of continence care and possible improvements.

Results
It is expected that the intention to use will be confirmed by nurses, and the number of nursing problems, such as bladder dysfunction-induced bedwetting, will be reduced with a high rating of DAT usability.

Conclusions
First, this study aims to produce multilevel innovative impacts, including practical, scientific, and societal effects. The results will provide practical solutions for workload reduction in the field of nursing support for continence care, where digital assistive technologies are becoming increasingly important. The DFree ultrasonic sensor is a new technical tool for the treatment of bladder dysfunction. Generating feedback to improve technical applications can increase the user-friendliness and usefulness of the device.

Trial Registration
Deutsches Register Klinischer Studien DRKS00031483; https://drks.de/search/en/trial/DRKS00031483

International Registered Report Identifier (IRRID)
PRR1-10.2196/47025
Performance of GPT-3.5 and GPT-4 on the Japanese Medical Licensing Examination: Comparison Study
Authors: Takagi Soshi , Watari Takashi , Erabi Ayano , Sakaguchi Kota 
Published: June 2023

Background
The competence of ChatGPT (Chat Generative Pre-Trained Transformer) in non-English languages is not well studied.

Objective
This study compared the performances of GPT-3.5 (Generative Pre-trained Transformer) and GPT-4 on the Japanese Medical Licensing Examination (JMLE) to evaluate the reliability of these models for clinical reasoning and medical knowledge in non-English languages.

Methods
This study used the default mode of ChatGPT, which is based on GPT-3.5; the GPT-4 model of ChatGPT Plus; and the 117th JMLE in 2023. A total of 254 questions were included in the final analysis, which were categorized into 3 types, namely general, clinical, and clinical sentence questions.

Results
The results indicated that GPT-4 outperformed GPT-3.5 in terms of accuracy, particularly for general, clinical, and clinical sentence questions. GPT-4 also performed better on difficult questions and specific disease questions. Furthermore, GPT-4 achieved the passing criteria for the JMLE, indicating its reliability for clinical reasoning and medical knowledge in non-English languages.

Conclusions
GPT-4 could become a valuable tool for medical education and clinical support in non–English-speaking regions, such as Japan.
Evaluating household coal slag emissions in Binh Chanh District, Ho Chi Minh City, Viet Nam and recommended solutions
Authors: Tran Thi Thanh Ngoc , Thai Phuong Vu 
Published: June 2023

In Viet Nam, apart from coal-fired power plants, coal slag also emitted from households via coal burning activities. However, the quantity of slag emitted from households has been rarely determined, and most of it is not been well-treated. In addition, it is well-known that the untreated or mistreated coal slag can lead to severe impacts on both the environment and human health. Therefore, it is necessary to evaluate the emission of this slag, and thereafter to provide recommendations for improved management. In this study, the emission of household coal slag in Binh Chanh District of Ho Chi Minh City, Vietnam was investigated by undertaking a fact-finding survey coupled with GPS. Coal burning experiments were also performed for various fuels including large-sized honeycomb charcoal (3 kg/piece); small-sized honeycomb charcoal (1.7 kg/piece); charcoal (1 kg) and dried firewood with rice husk (1 kg) to estimate the quantity of household coal slag emissions slag, as well as to primarily examine the impact to the environment and human health. Results showed that the emissions of household coal slag in the study area was considerable, up to 146 tonnes per year, almost 60% of which, was directly discharged into the environment. The burning coal for household purposes was found to dramatically change the quality of air with high concentration of pollutants including formaldehyde (HCHC), total volatile organic compound (TVOC), as well as particulate matters (PM2.5 and PM10) in exceedance of national standards which led to health effects. Finally, solutions for managing the slag were proposed.
Evaluating different diets on the growth performance of mud crab (Scylla serrata)
Authors: Gabito Porfirio P. , Baltar Christia 
Published: June 2023

The purpose of this study was to assess the potential of natural feeds for the sustainable grow-out aquaculture of mud crabs as an alternative to commercially available mud crab feeds. This study employed a completely randomized design that includes five feed treatments including trash fish, African land snail, horn snail, edible frog, and mud snail. There were three replicates for each treatment with three cages each located in a concrete tank with an area of 12m2. Each cage contained one lean crab. The crabs were fed twice a day, at 7 a.m. and 8 p.m. with an amount adjusted to 7% of the crab's body weight. After the first 21 days, all the crabs were harvested by draining out the tank water and the pincers of the crab were tied with a string to enable handling. The results showed that the highest growth performance in weight gain and condition factor was seen in African land snail feed with a feed conversion ratio of 1.38, indicating a high-quality feed. It also showed an impressive ROI of 96.8% which can be confirmed that this kind of feed might be a viable mud crab feed for both commercial scale and industry.
Mô hình tối ưu hóa tuyến đường vận chuyển trong chuỗi cung ứng lạnh nông sản
Authors: Trần Thị Thắm , Nguyễn Đoan Trinh 
Published: June 2023

Chuỗi cung ứng lạnh là chuỗi cung ứng các loại sản phẩm dễ hư hỏng từ nơi xuất xứ, qua các quy trình chế biến, lưu trữ, vận chuyển, phân phối và tiếp thị dưới nhiệt độ cần thiết để đảm bảo an toàn, giảm tổn thất và ngăn ngừa ô nhiễm. Trong chuỗi cung ứng lạnh, một trong những yêu cầu cần thiết là tối thiểu thời gian và tuyến đường vận chuyển, nhằm đảm bảo chất lượng sản phẩm cũng như hiệu quả chi phí. Bài báo này xây dựng mô hình toán nhằm tối thiểu tổng chi phí thông qua việc lựa chọn tuyến đường có thời gian di chuyển ngắn nhất. Bài toán được xây dựng dựa trên mô hình quy hoạch tuyến đường VRP và mô hình lập trình phi tuyến (Non-linear Programming_NLP). Hoạt động phân phối của chuỗi cửa hàng Bách Hóa Xanh tại quận Ninh Kiều, thành Phố Cần Thơ được sử dụng làm ví dụ cho mô hình đề xuất. Kết quả phân tích cung cấp tuyến đường vận chuyển thích hợp nhằm cải thiện chi phí logistics trong trường hợp nghiên cứu tại 18 điểm cửa hàng Bách Hóa Xanh, làm tiền đề phát triển và áp dụng mô hình, góp phần nâng cao hiệu quả hoạt động cho toàn chuỗi.
Thiết kế mô hình hỗ trợ giảng dạy thực hành châm cứu bằng kỹ thuật thị giác máy tính
Authors: Lưu Trọng Hiếu , Cao Hoàng Long , Phạm Duy Đức , Trần Minh Mẫn , Lê Hồng Phước , Trần Lê Trung Chánh 
Published: June 2023

Nghiên cứu trình bày mô hình hỗ trợ giảng dạy thực hành châm cứu cho sinh viên ngành Y học dân tộc bằng kỹ thuật thị giác máy tính. Mô hình gồm một máy ảnh thương mại, một máy tính nhúng Raspberry Pi có thể kết nối tới màn hình máy tính. Phần mềm được thiết kế bằng Python trên nền tảng thư viện OpenCV, trên hệ điều hành Ubuntu. Hệ thống có thể đo được góc châm, độ sâu của kim và vận tốc khi châm. Kết quả cho thấy hệ thống cho độ chính xác cao với các sai số nhỏ. Nghiên cứu đã được hội đồng khoa học trường đại học Y Dược Cần Thơ thông qua và đang được sử dụng giảng dạy để đánh giá ưu điểm của thiết bị so với phương pháp giảng dạy truyền thống.
Nghiên cứu sử dụng vật liệu Cu/ZIF làm xúc tác xử lý malachite green với sự có mặt của hydrogen peroxide
Authors: Phạm Trần Bảo Nghi , Trần Bá Huy , Hồ Ngọc Tri Tân , Đặng Huỳnh Giao 
Published: June 2023

Nghiên cứu này nhằm tổng hợp vật liệu khung lưỡng kim Cu/ZIF-67 và đánh giá khả năng xúc tác của nó. Cu/ZIF-67 được tổng hợp thành công trong dung môi ethanol bằng sóng siêu âm. Vật liệu được phân tích tính chất đặc trưng bằng các phương pháp phân tích hiện đại. Kết quả cho thấy vật liệu có cấu trúc đa diện với kích thước tinh thể đồng đều cùng diện tích bề mặt riêng lớn với diện tích bề mặt Brunauer-Emmett-Teller (BET) là 1241,8 m2.g-1. Bên cạnh đó, vật liệu được đánh giá khả năng xúc tác xử lý malachite green với sự có mặt của hydrogene peroxide. Kết quả cho thấy rằng hiệu suất xử lý malachite green đạt đến hơn 98% với nồng độ H2O2 là 0,06 M, lượng Cu/ZIF-67 sử dụng là 50 mg/L, nồng độ malachite green ban đầu là 50 mg/L, được xử lý trong 30 phút ở nhiệt độ phòng.
Xây dựng môi trường dựa trên đám mây cho việc giám sát hệ thống năng lượng tòa nhà
Authors: Lê Trần Thái Bình , Phạm Đăng Quang , Nguyễn Phúc Khải , Trần Minh Quang , Đặng Chí Cường 
Published: June 2023

Bài báo nhằm mục đích xây dựng mô hình sử dụng môi trường dựa trên đám mây để giám sát hệ thống điện trong một khuôn viên với các mục tiêu nhằm nâng cao chất lượng môi trường sống và sử dụng điện hiệu quả trong bối cảnh phát triển bền vững. Thực tế, việc áp dụng công nghệ LoRaWAN có thể trở thành một giải pháp rất hứa hẹn, do khả năng phủ sóng tốt ở ngoài trời và trong môi trường hỗn hợp, tầm xa thay vì giải pháp LAN hoặc truyền thông đường dây điện PLC. Cách tiếp cận được đưa ra là sử dụng LoraWAN kết hợp với môi trường dựa trên đám mây để giám sát diện rộng một khuôn viên, một tòa nhà hoặc một khu vực. Kết quả đạt được với các thông số nguồn trong hệ thống điện có thể hiển thị trên các thiết bị ứng dụng di động và ứng dụng trình duyệt web, ngoài ra còn xây dựng được cơ sở dữ liệu đám mây để nghiên cứu tiêu thụ năng lượng cho tòa nhà. Trong tương lai, kết quả này sẽ góp phần nhỏ vào thực tiễn Việt Nam đang phát triển Thành phố thông minh, Khu công nghệ cao thông minh và kiểm soát tối ưu việc sử dụng điện của phụ tải trong hệ thống điện phân tán.
Novel Metal Coordination Complexes Based on 4-Aminophenol: Spectroscopic Analysis and Antibacterial Test
Authors: Syaima Husna , Rahardjo Sentot Budi , Hanifa Anisa Nurul , Fathonah Ariffah Ana , Setyaningsih Ratna 
Published: June 2023

The aims of this research are to synthesize and determine the formula, characteristics, and complex structure of Cu(II) and Co(II) with 4-aminophenol and to investigate their antibacterial activity. The complexes were synthesized by refluxing a solution of CuSO4·5H2O and CoSO4·7H2O, respectively, with 4-aminophenol in methanol for 1 h. The products were characterized using UV-Vis spectroscopy, atomic absorption spectroscopy, thermal analysis, conductivity, FTIR, and magnetic moment. The formation of the complex was indicated by shifting of maximum wavelength of the metal solution toward shorter, i.e., 817 to 421 nm for Cu(II) and 566 to 450 nm for Co(II). From the characterization, the proposed formulas of the complexes are [Cu(4-aminophenol)4]SO4 and [Co(4-aminophenol)4(H2O)2]SO4·5H2O forming square planar and octahedral geometry, respectively. Both complexes are paramagnetic with negligible antibacterial activity against Staphylococcus aureus, Staphylococcus epidermis, Escherichia coli, and Pseudomonas aeruginosa.
Robust Biocomposite Film of Polylactic Acid and Ferroferric Oxide as a Radar Absorbing Material
Authors: Sinaga Rafles , Kusumaningrum Wida Banar , Taryana Yana , Fatriasari Widya , Hami Zuratul Ain Abdul , Suryanegara Lisman , Holilah Holilah , Darma Yudi 
Published: June 2023

The polymer/ferroferric oxide (Fe3O4) foam and aerogel composites generally exhibit superior radar absorptivity performance. However, these composites have poor mechanical and thermal properties. This study manufactured a polylactic acid (PLA)/Fe3O4 bio-composite and evaluated the radar absorptivity, thermal, and mechanical properties of radar-absorbing material. The composites were prepared using a solvent casting method to mix PLA and Fe3O4 at varying concentrations, followed by evaporation, oven drying, and hot pressing into a film. Thermogravimetric analysis showed that the decomposition temperature of the PLA/Fe3O4-5% composite occurred at around 306 °C, which shifted to a lower decomposition temperature of PLA. The addition of 25 wt.% Fe3O4 improved the tensile modulus of neat PLA from 2.92 to 3.55 GPa. The vector network analyzer demonstrated that the addition of Fe3O4 at 25% improved the reflection loss of PLA from –5.17 to -25.83 dB at a thickness of 3 mm, with energy absorbed by 99.74% at frequency position 10.58 GHz. These results demonstrated that PLA/Fe3O4 composites have great potential in radar-absorbing practical applications.
The Potential of <i>Clerodendrum paniculatum</i> Leaves Fraction as a 3-Chymotrypsin-Like (3CL) Protease Inhibitor of SARS-CoV-2
Authors: Arba Muhammad , Arfan Arfan , Yamin Yamin , Zubair Muhammad Sulaiman 
Published: June 2023

We described the biological activity of the Clerodendrum paniculatum leaf fraction against the SARS-CoV-2 3-Chymotrypsin-like 3CL protease at the molecular level. This study applied LC-MS/MS to identify bioactive compounds from fractions, computational studies, and fluorescence resonance energy transfer (FRET) assays to ascertain their inhibitory activity. LC-MS/MS analysis of the three samples revealed that sample 1 contained 18 compound peaks. In samples 2 and 3, there were 23 and 25 compounds with different molecular weights, respectively. Docking's study identified that the alkaloids (komarovicine and roemerine) have lower binding energies than other metabolites and standard compounds, with values of -33.47 and -32.63 kJ/mol, respectively. Roemerine demonstrated excellent stability based on dynamic simulation results and confirmed its affinity for 3CL protease predicted by the MM-PBSA approach of -89.44 kJ/mol. The FRET method for testing 3CL protease activity revealed that sample 2 had an enzyme inhibitory activity of 94.3%, which was close to that of GC376 (98.19%). Meanwhile, samples 1 and 3 yielded satisfactory inhibition activity by 89.64% and 85.24%, respectively. The antiviral activity of C. paniculatum leaves was discovered for the first time by inhibiting the 3CL protease SARS-CoV-2, providing an excellent opportunity for its development as an anti-SARS-CoV-2.
Development of Methylmercury Analysis by Ultra-High Performance Liquid Chromatography Coupled with ICP-MS and Its Application on Sharks’ Meat Measurement
Authors: Suratno Suratno , Wahono Satriyo Krido , Siswanta Dwi , Aprilita Nurul Hidayat 
Published: June 2023

This study analyzed MeHg in a fast, simple, low-waste, and accurate by using ultra-high liquid chromatography coupled with inductively coupled plasma mass spectrometry. Simple preparation by liquid extraction with sonication at room temperature was effective extract MeHg from Certified Reference Material (CRM) and shark meat samples. Effective MeHg separation was achieved in less than 300 s using a C18 Hypersil Gold analytical column with a mobile gradient phase of 0.5% (w/v) L-cysteine in 2% (v/v) HNO3 and 100% methanol. The MeHg was extracted from 100 mg of shark meat using 1 mL of 0.5% (w/v) L-cysteine in 2% (v/v) HNO3 and sonicated for 30 min. Analysis of certified reference material (DORM-4) showed values between the experimental and certified values. The observed limit of detection and quantification MeHg were 0.86 and 2.85 pg/L, respectively. This method was applied to measure MeHg in shark meat from Binuangeun areas. The MeHg concentration in Rhizoprionodon acutus was 0.22–0.63 mg/kg wet weight (w.w.), Squalus hemipinis 0.68–1.14 mg/kg w.w., and 0.29–1.22 mg/kg w.w. for Sphyrna lewini. This study provides a quick and easy method to evaluate MeHg in shark meat or other seafood products and applies to many samples in a single assay.
Immunosuppression versus Supportive Care on Kidney Outcomes in IgA Nephropathy in the Real-World Setting
Authors: Zhao Hao , Li Yang , Sun Jingdi , Xu Gang , Wang Cheng , Zhou Shiyu , Nie Sheng , Li Yanqin , Su Licong , Chen Ruixuan , Cao Yue , Gao Qi , Hu Ying , Li Hua , Yang Qiongqiong , Wan Qijun , Liu Bicheng , Xu Hong , Li Guisen , Weng Jianping , Chen Chunbo , Liu Huafeng , Shi Yongjun , Zha Yan , Kong Yaozhong , Su Guobin , Tang Ying , Zhou Yilun , Guo Aixin , Gong Mengchun , Xu Xin , Hou Fan Fan 
Published: June 2023

Background
The efficacy of immunosuppression in the management of immunoglobulin A (IgA) nephropathy remains highly controversial. The study was conducted to assess the effect of immunosuppression, compared with supportive care, in the real-world setting of IgA nephropathy.

Methods
A cohort of 3946 patients with IgA nephropathy, including 1973 new users of immunosuppressive agents and 1973 propensity score-matched recipients of supportive care, in a nationwide register data from January 2019 to May 2022 in China was analyzed. The primary outcome was a composite of 40% eGFR decrease of the baseline, kidney failure, and all-cause mortality. A Cox proportional hazard model was used to estimate the effects of immunosuppression on the composite outcomes and its components in the propensity score-matched cohort.

Results
Among 3946 individuals (mean [SD] age 36 [10] years, mean [SD] eGFR 85 [28] ml/min per 1.73 m2, and mean [SD] proteinuria 1.4 [1.7] g/24 hours), 396 primary composite outcome events were observed, of which 156 (8%) were in the immunosuppression group and 240 (12%) in the supportive care group. Compared with supportive care, immunosuppression treatment was associated with 40% lower risk of the primary outcome events (adjusted hazard ratio, 0.60; 95% confidence interval, 0.48 to 0.75). Comparable effect size was observed for glucocorticoid monotherapy and mycophenolate mofetil alone. In the prespecified subgroup analysis, the treatment effects of immunosuppression were consistent across ages, sexes, levels of proteinuria, and values of eGFR at baseline. Serious adverse events were more frequent in the immunosuppression group compared with the supportive care group.

Conclusions
Immunosuppressive therapy, compared with supportive care, was associated with a 40% lower risk of clinically important kidney outcomes in patients with IgA nephropathy.