bluuebunny/crossref_metadata_2025_split huggingface dataset:
Making the unconscious conscious: Developing maladaptive scripts into conviction narratives
Authors: Siegel Paul 
Published: May 2023

Abstract
In his ‘script theory,' Tomkins first proposed that people unconsciously organize their life experiences in terms of narrative structures he termed “scripts.” I use a clinical vignette to illustrate how the psychotherapeutic process of “making the unconscious conscious” involves becoming aware of the maladaptive scripts that people unwittingly live by, and developing them into the “conviction narratives” proposed by the authors.
What makes narratives feel right? The role of metacognitive experiences
Authors: Schwarz Norbert 
Published: May 2023

Abstract
Conviction Narrative Theory holds that reasoners adopt “a narrative that feels ‘right’ to explain the available data” and use “that narrative to imagine plausible futures” (target article, Abstract). Drawing on feelings-as-information theory, this commentary reviews the role of metacognitive experiences of ease or difficulty and highlights that fluently processed narratives are more likely to “feel right.”
Myopericarditis following COVID-19 vaccination in adolescent triplets
Authors: Wong Jessica W. , Bock Erin , Kee Wooi Seng , Anderson Aleisha J. , Kothari Darshan , Tarca Adrian J. 
Published: May 2023

AbstractMultiple studies have reported myocarditis and pericarditis after the Pfizer-BioNTech coronavirus disease 2019 messenger ribonucleic acid vaccine. We describe male adolescent triplets who presented with myopericarditis within one week following vaccine administration.
Effects of Secondary Carbonate Precipitation and Dissolution on Changjiang (Yangtze) River Chemistry and Estimates of Silicate Weathering Rates
Authors: Li Shilei , Li Gen K. , Li Weiqiang , Chen Yang , Raymo Maureen E. , Chen Jun 
Published: May 2023

AbstractRiverine solute chemistry has long been used to infer modern weathering fluxes and processes by assuming that river‐dissolved loads are conservative mixtures of weathering products of different lithologies. Secondary carbonate precipitation and re‐dissolution are important processes that can alter the original weathering fluxes. However, it remains less well understood how secondary carbonates affect the solute chemistry of large rivers and the estimates of silicate weathering rates. Here we report the elemental and Sr‐Mg isotopic compositions of the Changjiang (Yangtze River) water collected biweekly from May 2010 to April 2011 and use this data set to explore the influence of secondary carbonate precipitation and re‐dissolution on the Changjiang river chemistry. Variable Ca/Sr and Ca/Mg ratios but stable 87Sr/86Sr and δ26Mg are observed, which can only be explained by the precipitation and dissolution of secondary carbonates. Across a range of possible Ca/Mg ratios of the primary weathering flux, we estimate that up to 30% of the dissolved Ca carried by Changjiang was controlled by secondary carbonate precipitation and re‐dissolution. Using inverse modeling, we show that secondary carbonate precipitation and re‐dissolution have a minor influence on the calculated silicate weathering rates. Our findings provide new insights into how secondary carbonates affect water chemistry in large river systems, highlighting the role of secondary carbonate precipitation and re‐dissolution in modulating riverine dissolved fluxes in the Changjiang basin.
Atmospheric CO2 Depletion Near the Surface in the Martian Polar Regions
Authors: Piqueux Sylvain , Hayne Paul O. , Kleinböhl Armin , Kass David M. , Schreier Mathias , McCleese Daniel J. , Richardson Mark I. , Schofield John T. , Heavens Nicholas , Shirley James H. 
Published: May 2023

AbstractThe kinetic temperature of the Martian seasonal caps is controlled by the partial pressure of atmospheric CO2 at the surface. When carbon dioxide condenses, typically near the poles, light non‐condensable species (Ar, N2, CO, etc.) accumulate in the atmosphere, resulting in a decrease of the CO2 partial pressure and depressing the local frost point temperature. The buoyant air should mix laterally and vertically within the polar vortices. Observations show that the Martian seasonal caps' kinetic temperatures are ∼0–4 K below the expected CO2 frost point, depending on latitude and season, indicating atmospheric CO2 gas depletion at the surface/atmosphere interface. In the North and South, we find relatively similar non‐condensable peak enhancement factors (e.g., EFNC ∼ 6–8, up to ∼8.7 in the North) at most latitudes, confirming the efficient meridional mixing within the polar vortices, despite steep surface condensation gradients. In the South, this surface enhancement is similar to column‐integrated values derived from Gamma Ray Spectrometer data, indicating efficient vertical mixing. But in the North, the surface depletion is much larger than in the entire column, suggesting poor vertical mixing. Reduced infrared emission of the seasonal caps stemming from CO2 depletion is not a major energy balance factor. This work illustrates how the atmosphere's composition at the surface can be significantly different from column‐integrated values.
Modeling Intensity‐Duration‐Frequency Curves for the Whole Range of Non‐Zero Precipitation: A Comparison of Models
Authors: Haruna Abubakar , Blanchet Juliette , Favre Anne‐Catherine 
Published: May 2023

AbstractIntensity‐duration‐frequency (IDF) curves are useful in water resources engineering for the planning and design of hydrological structures. As opposed to the common use of only extreme data to build IDF curves, here, we use all the non‐zero rainfall intensities, thereby making efficient use of the available information. We use the extended generalized Pareto distribution to model the distribution of the non‐zero rainfall intensities. We consider three commonly used approaches for building IDF curves. The first approach is based on the scale‐invariance property of rainfall, the second relies on the general IDF formulation of Koutsoyiannis et al. (1998, https://doi.org/10.1016/S0022-1694(98)00097-3), and the last approach is purely data‐driven(Overeem et al., 2008, https://doi.org/10.1016/j.jhydrol.2007.09.044). Using these three approaches, and some extensions around them, we build a total of 10 models for the IDF curves, and then we compare them in a split‐sampling cross‐validation framework. We consider a total of 81 stations at 10 min resolution in Switzerland. Due to the marked seasonality of rainfall in the study area, we performed a seasonal‐based analysis. The results reveal the model based on the data‐driven approach as the best model. It is able to correctly model the observed intensities across duration while being reliable and robust. It is also able to reproduce the space and time variability of extreme rainfall across Switzerland.
Predation of oomycetes by myxobacteria via a specialized CAZyme system arising from adaptive evolution
Authors: Zhang Lei , Dong Chaonan , Wang Jihong , Liu Muxing , Wang Juying , Hu Jiexiong , Liu Lin , Liu Xinyu , Xia Chengyao , Zhong Lingli , Zhao Yuqiang , Ye Xianfeng , Huang Yan , Fan Jiaqin , Cao Hui , Wang Jingjing , Li Yuezhong , Wall Daniel , Li Zhoukun , Cui Zhongli 
Published: May 2023

Abstract
As social micropredators, myxobacteria are studied for their abilities to prey on bacteria and fungi. However, their predation of oomycetes has received little attention. Here, we show that Archangium sp. AC19 secretes a carbohydrate-active enzyme (CAZyme) cocktail during predation on oomycetes Phytophthora. These enzymes include three specialized β-1,3-glucanases (AcGlu13.1, –13.2 and –13.3) that act as a cooperative consortium to target β-1,3-glucans of Phytophthora. However, the CAZymes showed no hydrolytic effects on fungal cells, even though fungi contain β-1,3-glucans. Heterologous expression of AcGlu13.1, –13.2 or –13.3 enzymes in Myxococcus xanthus DK1622, a model myxobacterium that antagonizes but does not predate on P. sojae, conferred a cooperative and mycophagous ability that stably maintains myxobacteria populations as a mixture of engineered strains. Comparative genomic analyses suggest that these CAZymes arose from adaptive evolution among Cystobacteriaceae myxobacteria for a specific prey killing behavior, whereby the presence of Phytophthora promotes growth of myxobacterial taxa by nutrient release and consumption. Our findings demonstrate that this lethal combination of CAZymes transforms a non-predatory myxobacterium into a predator with the ability to feed on Phytophthora, and provides new insights for understanding predator-prey interactions. In summary, our work extends the repertoire of myxobacteria predatory strategies and their evolution, and suggests that these CAZymes can be engineered as a functional consortium into strains for biocontrol of Phytophothora diseases and hence crop protection.
Identification of heat shock protein family A member 5 (HSPA5) targets involved in nonalcoholic fatty liver disease
Authors: Rehati Aliya , Abuduaini Buzukela , Liang Zhao , Chen Dong , He Fangping 
Published: May 2023

AbstractHeat shock protein family A (Hsp70) member 5 (HSPA5) is an endoplasmic reticulum chaperone, which regulates cell metabolism, particularly lipid metabolism. While HSPA5’s role in regulating cell function is well described, HSPA5 binding to RNA and its biological function in nonalcoholic fatty liver disease (NAFLD) is still lacking. In the present study, the ability of HSPA5 to modulate alternative splicing (AS) of cellular genes was assessed using Real-Time PCR on 89 NAFLD-associated genes. RNA immunoprecipitation coupled to RNA sequencing (RIP-Seq) assays were also performed to identify cellular mRNAs bound by HSPA5. We obtained the HSPA5-bound RNA profile in HeLa cells and peak calling analysis revealed that HSPA5 binds to coding genes and lncRNAs. Moreover, RIP-Seq assays demonstrated that HSPA5 immunoprecipitates specific cellular mRNAs such as EGFR, NEAT1, LRP1 and TGFß1, which are important in the pathology of NAFLD. Finally, HSPA5 binding sites may be associated with splicing sites. We used the HOMER algorithm to search for motifs enriched in coding sequence (CDs) peaks, which identified over-representation of the AGAG motif in both sets of immunoprecipitated peaks. HSPA5 regulated genes at the 5′UTR alternative splicing and introns and in an AG-rich sequence-dependent manner. We propose that the HSPA5-AGAG interaction might play an important role in regulating alternative splicing of NAFLD-related genes. This report is the first to demonstrate that HSPA5 regulated pre-RNA alternative splicing, stability, or translation and affected target protein(s) via binding to lncRNA and mRNA linked to NAFLD.
Lysosomal-associated protein transmembrane 5 ameliorates non-alcoholic steatohepatitis by promoting the degradation of CDC42 in mice
Authors: Jiang Lang , Zhao Jing , Yang Qin , Li Mei , Liu Hao , Xiao Xiaoyue , Tian Song , Hu Sha , Liu Zhen , Yang Peiwen , Chen Manhua , Ye Ping , Xia Jiahong 
Published: May 2023

AbstractNon-alcoholic steatohepatitis (NASH) has received great attention due to its high incidence. Here, we show that lysosomal-associated protein transmembrane 5 (LAPTM5) is associated with NASH progression through extensive bioinformatical analysis. The protein level of LAPTM5 bears a negative correlation with NAS score. Moreover, LAPTM5 degradation is mediated through its ubiquitination modification by the E3 ubquitin ligase NEDD4L. Discovered by experiments conducted on male mice, hepatocyte-specific depletion of Laptm5 exacerbates mouse NASH symptoms. In contrast, Laptm5 overexpression in hepatocytes exerts diametrically opposite effects. Mechanistically, LAPTM5 interacts with CDC42 and promotes its degradation through a lysosome-dependent manner under the stimulation of palmitic acid, thus inhibiting activation of the mitogen-activated protein kinase signaling pathway. Finally, adenovirus-mediated hepatic Laptm5 overexpression ameliorates aforementioned symptoms in NASH models.
Microcantilever-integrated photonic circuits for broadband laser beam scanning
Authors: Sharif Azadeh Saeed , Mak Jason C. C. , Chen Hong , Luo Xianshu , Chen Fu-Der , Chua Hongyao , Weiss Frank , Alexiev Christopher , Stalmashonak Andrei , Jung Youngho , Straguzzi John N. , Lo Guo-Qiang , Sacher Wesley D. , Poon Joyce K. S. 
Published: May 2023

AbstractLaser beam scanning is central to many applications, including displays, microscopy, three-dimensional mapping, and quantum information. Reducing the scanners to microchip form factors has spurred the development of very-large-scale photonic integrated circuits of optical phased arrays and focal plane switched arrays. An outstanding challenge remains to simultaneously achieve a compact footprint, broad wavelength operation, and low power consumption. Here, we introduce a laser beam scanner that meets these requirements. Using microcantilevers embedded with silicon nitride nanophotonic circuitry, we demonstrate broadband, one- and two-dimensional steering of light with wavelengths from 410 nm to 700 nm. The microcantilevers have ultracompact ~0.1 mm2 areas, consume ~31 to 46 mW of power, are simple to control, and emit a single light beam. The microcantilevers are monolithically integrated in an active photonic platform on 200-mm silicon wafers. The microcantilever-integrated photonic circuits miniaturize and simplify light projectors to enable versatile, power-efficient, and broadband laser scanner microchips.
Inhibition of CXorf56 promotes PARP inhibitor-induced cytotoxicity in triple-negative breast cancer
Authors: Zhu Ying , Liu Zhixian , Gui Liang , Yun Wen , Mao Changfei , Deng Rong , Yao Yufeng , Yu Qiao , Feng Jifeng , Ma Hongxia , Bao Wei 
Published: May 2023

AbstractPoly(ADP-ribose) polymerase inhibitors (PARPis) induce DNA lesions that preferentially kill homologous recombination (HR)-deficient breast cancers induced by BRCA mutations, which exhibit a low incidence in breast cancer, thereby limiting the benefits of PARPis. Additionally, breast cancer cells, particularly triple-negative breast cancer (TNBC) cells, exhibit HR and PARPi resistance. Therefore, targets must be identified for inducing HR deficiency and sensitizing cancer cells to PARPis. Here, we reveal that CXorf56 protein increased HR repair in TNBC cells by interacting with the Ku70 DNA-binding domain, reducing Ku70 recruitment and promoting RPA32, BRCA2, and RAD51 recruitment to sites of DNA damage. Knockdown of CXorf56 protein suppressed HR in TNBC cells, specifically during the S and G2 phases, and increased cell sensitivity to olaparib in vitro and in vivo. Clinically, CXorf56 protein was upregulated in TNBC tissues and associated with aggressive clinicopathological characteristics and poor survival. All these findings indicate that treatment designed to inhibit CXorf56 protein in TNBC combined with PARPis may overcome drug resistance and expand the application of PARPis to patients with non-BRCA mutantion.
A new route to fabricate flexible, breathable composites with advanced thermal management capability for wearable electronics
Authors: Chen Huibao , Ding Yafei , Zhu Guimei , Liu Yu , Fang Qun , Bai Xue , Zhao Yan , Li Xin , Huang Xingyi , Zhang Tong-Yi , Li Baowen , Sun Bin 
Published: May 2023

AbstractWearable electronics with miniaturization and high-power density call for devices with advanced thermal management capabilities, outstanding flexibility, and excellent permeability. However, it is difficult to achieve these goals simultaneously due to the conflict between high thermal conductivity and permeability and flexibility. Here, we report an approach to fabricate flexible, breathable composites with advanced thermal management capability by coating the boron nitride nanosheets (BNNSs) layer with high thermal conductivity on the grids of patterned electrospun thermoplastic polyurethane (TPU) fibrous mats. The composite exhibited a significant enhancement of thermal conductivity and preserved instinctive breathability simultaneously. When the composite was integrated into flexible devices, its saturating operating temperature dropped significantly compared to that of pure Ecoflex packaging. Moreover, the surface temperature fluctuation was less than 0.5 °C during more than 2000 cycles bending-releasing process. Finally, a prototype to fabricate wearable electronics with advanced thermal management capability was proposed.
Fast and accurate protein structure search with Foldseek
Authors: van Kempen Michel , Kim Stephanie S. , Tumescheit Charlotte , Mirdita Milot , Lee Jeongjae , Gilchrist Cameron L. M. , Söding Johannes , Steinegger Martin 
Published: May 2023

AbstractAs structure prediction methods are generating millions of publicly available protein structures, searching these databases is becoming a bottleneck. Foldseek aligns the structure of a query protein against a database by describing tertiary amino acid interactions within proteins as sequences over a structural alphabet. Foldseek decreases computation times by four to five orders of magnitude with 86%, 88% and 133% of the sensitivities of Dali, TM-align and CE, respectively.
A deep learning algorithm to predict risk of pancreatic cancer from disease trajectories
Authors: Placido Davide , Yuan Bo , Hjaltelin Jessica X. , Zheng Chunlei , Haue Amalie D. , Chmura Piotr J. , Yuan Chen , Kim Jihye , Umeton Renato , Antell Gregory , Chowdhury Alexander , Franz Alexandra , Brais Lauren , Andrews Elizabeth , Marks Debora S. , Regev Aviv , Ayandeh Siamack , Brophy Mary T. , Do Nhan V. , Kraft Peter , Wolpin Brian M. , Rosenthal Michael H. , Fillmore Nathanael R. , Brunak Søren , Sander Chris 
Published: May 2023

AbstractPancreatic cancer is an aggressive disease that typically presents late with poor outcomes, indicating a pronounced need for early detection. In this study, we applied artificial intelligence methods to clinical data from 6 million patients (24,000 pancreatic cancer cases) in Denmark (Danish National Patient Registry (DNPR)) and from 3 million patients (3,900 cases) in the United States (US Veterans Affairs (US-VA)). We trained machine learning models on the sequence of disease codes in clinical histories and tested prediction of cancer occurrence within incremental time windows (CancerRiskNet). For cancer occurrence within 36 months, the performance of the best DNPR model has area under the receiver operating characteristic (AUROC) curve = 0.88 and decreases to AUROC (3m) = 0.83 when disease events within 3 months before cancer diagnosis are excluded from training, with an estimated relative risk of 59 for 1,000 highest-risk patients older than age 50 years. Cross-application of the Danish model to US-VA data had lower performance (AUROC = 0.71), and retraining was needed to improve performance (AUROC = 0.78, AUROC (3m) = 0.76). These results improve the ability to design realistic surveillance programs for patients at elevated risk, potentially benefiting lifespan and quality of life by early detection of this aggressive cancer.
CD69 serves as a potential diagnostic and prognostic biomarker for hepatocellular carcinoma
Authors: Tang Kaihua , Li Xiaoting , Mo Jianwen , Chen Yixuan , Huang Chengyu , Li Ting , Luo Tianjian , Zhong Zhijian , Jiang Yongqiang , Yang Dengfeng , Mo Weiliang 
Published: May 2023

AbstractThe prevalence and mortality of hepatocellular carcinoma (HCC) are still increasing. This study aimed to identify potential therapeutic targets related to patient prognosis. Data were downloaded from TCGA, GSE25097, GSE36376, and GSE76427 datasets. Differential analysis and enrichment analysis were performed in HCC. Cell deaths were evaluated, and least absolute shrinkage and selection operator regression (LASSO) regression was analyzed to screen candidate genes. Additionally, immune cell infiltration in HCC was assessed. We identified 4088 common DEGs with the same direction of differential expression in all four datasets, they were mainly enriched in immunoinflammation and cell cycle pathways. Apoptosis was significantly suppressed in HCC in GSEA and GSVA. After LASSO regression analysis, we screened CD69, CDC25B, MGMT, TOP2A, and TXNIP as candidate genes. Among them, CD69 significantly influenced the overall survival of HCC patients in both TCGA and GSE76427. CD69 may be a protective factor for outcome of HCC patients. In addition, CD69 was positive correlation with T cells and CD3E. CD69, CDC25B, MGMT, TOP2A, and TXNIP were potential diagnostic and prognostic target for HCC, especially CD69.
Optimizing 3DCT image registration for interfractional changes in carbon-ion prostate radiotherapy
Authors: Hirai Ryusuke , Mori Shinichiro , Suyari Hiroki , Tsuji Hiroshi , Ishikawa Hitoshi 
Published: May 2023

AbstractTo perform setup procedures including both positional and dosimetric information, we developed a CT–CT rigid image registration algorithm utilizing water equivalent pathlength (WEPL)-based image registration and compared the resulting dose distribution with those of two other algorithms, intensity-based image registration and target-based image registration, in prostate cancer radiotherapy using the carbon-ion pencil beam scanning technique. We used the data of the carbon ion therapy planning CT and the four-weekly treatment CTs of 19 prostate cancer cases. Three CT–CT registration algorithms were used to register the treatment CTs to the planning CT. Intensity-based image registration uses CT voxel intensity information. Target-based image registration uses target position on the treatment CTs to register it to that on the planning CT. WEPL-based image registration registers the treatment CTs to the planning CT using WEPL values. Initial dose distributions were calculated using the planning CT with the lateral beam angles. The treatment plan parameters were optimized to administer the prescribed dose to the PTV on the planning CT. Weekly dose distributions using the three different algorithms were calculated by applying the treatment plan parameters to the weekly CT data. Dosimetry, including the dose received by 95% of the clinical target volume (CTV-D95), rectal volumes receiving > 20 Gy (RBE) (V20), > 30 Gy (RBE) (V30), and > 40 Gy (RBE) (V40), were calculated. Statistical significance was assessed using the Wilcoxon signed-rank test. Interfractional CTV displacement over all patients was 6.0 ± 2.7 mm (19.3 mm maximum standard amount). WEPL differences between the planning CT and the treatment CT were 1.2 ± 0.6 mm-H2O (< 3.9 mm-H2O), 1.7 ± 0.9 mm-H2O (< 5.7 mm-H2O) and 1.5 ± 0.7 mm-H2O (< 3.6 mm-H2O maxima) with the intensity-based image registration, target-based image registration, and WEPL-based image registration, respectively. For CTV coverage, the D95 values on the planning CT were > 95% of the prescribed dose in all cases. The mean CTV-D95 values were 95.8 ± 11.5% and 98.8 ± 1.7% with the intensity-based image registration and target-based image registration, respectively. The WEPL-based image registration was CTV-D95 to 99.0 ± 0.4% and rectal Dmax to 51.9 ± 1.9 Gy (RBE) compared to 49.4 ± 9.1 Gy (RBE) with intensity-based image registration and 52.2 ± 1.8 Gy (RBE) with target-based image registration. The WEPL-based image registration algorithm improved the target coverage from the other algorithms and reduced rectal dose from the target-based image registration, even though the magnitude of the interfractional variation was increased.