bluuebunny/crossref_metadata_2025_split huggingface dataset:
An LSTM+ Model for Managing Epidemics: Using Population Mobility and Vulnerability for Forecasting COVID-19 Hospital Admissions
Authors: Ray Arindam , Jank Wolfgang , Dutta Kaushik , Mullarkey Matthew 
Published: February 2023

Worldwide epidemics, such as corona virus disease 2019 (COVID-19), cause unprecedented challenges for society and its healthcare systems. Governments attempt to mitigate those challenges by either reducing healthcare demand (“flattening the curve” by imposing restrictions, e.g., on travel or social gatherings) or by increasing healthcare capacity, for example, by canceling elective procedures or setting up field hospitals. To implement these mitigation procedures efficiently, accurate and timely forecasts of the epidemic’s progression are necessary. In this paper, we develop an innovative forecasting methodology based on the ideas of long short-term memory (LSTM) recurrent neural networks. LSTM models are shown to outperform traditional forecasting models, especially when the relationship between input and output is complex and not available in closed form. However, whereas LSTM models perform well for data that changes dynamically over time, one shortcoming is that they are not directly applicable when the data also includes static, nontemporal components. In this work, we propose an [Formula: see text] model that overcomes this limitation. Our model leverages a private partnership with a mobile data company in order to capture population mobility (using mobility indices derived from mobile device data), which allows us to anticipate an epidemic’s spread early and accurately. In addition, we also leverage a public partnership with a consortium of hospitals. Using hospital admissions (rather than, say, positive caseload) results in an unbiased measure of the severity of an epidemic because patients seek and are admitted to hospital care only when symptoms worsen beyond a critical point. We illustrate the effectiveness of our method on forecasting COVID-19 for a major U.S. metropolitan area where it has aided decision makers of the emergency policy group. Our model improves the predictive accuracy of hospital admission by a factor of 2.5× as compared with competing models in the same analytical space. History: Accepted by J. Paul Brooks, Area Editor for Applications in Biology, Medicine, & Healthcare. Funding: This research was funded by a monetary gift from Hillsborough County to establish the Pandemic Response Research Fund at University of South Florida. Supplemental Material: The software that supports the findings of this study is available within the paper and its Supplemental Information ( https://pubsonline.informs.org/doi/suppl/10.1287/ijoc.2023.1269 ) as well as from the IJOC GitHub software repository ( https://github.com/INFORMSJoC/2021.0027 ) at ( http://dx.doi.org/10.5281/zenodo.7112004 ).
Search and Predictability of Prices in the Housing Market
Authors: Møller Stig Vinther , Pedersen Thomas , Montes Schütte Erik Christian , Timmermann Allan 
Published: February 2023

We develop a new housing search index (HSI) extracted from online search activity on a limited set of keywords related to the house-buying process. We show that HSI has strong predictive power over subsequent changes in house prices, both in-sample and out-of-sample and after controlling for the effect of commonly used predictors, and relate our findings to models of search-induced frictions. Our results imply that search data can be used as an early indicator of where the market is going.This paper was accepted by David Sraer, finance.Funding: We acknowledge support from the Danish Finance Institute and from the Independent Research Fund Denmark [Grants DFF 7024-00020B and DFF 7015-00017B].Supplemental Material: The online appendix and data are available at https://doi.org/10.1287/mnsc.2023.4672 .
Business Analytics in Healthcare: Past, Present, and Future Trends
Authors: Wowak Kaitlin D. , Lalor John P. , Somanchi Sriram , Angst Corey M. 
Published: February 2023

Problem definition: Business analytics (BA) in healthcare research offers numerous valuable insights that can enhance patient care and hospital performance. Consequently, there has been a rapid surge of research in this area. Academic/practical relevance: The objective of this study is to provide a data-driven summary of the extant BA in healthcare literature and a guide for future research. Methodology: Leveraging a topic modeling technique and network analysis, we provide insight into how BA topics change over time. Results: We provide an in-depth analysis of 320 articles from the University of Texas at Dallas journal list and a basic topic model and network analyses for an additional 6,515 relevant articles from PubMed published in top-tier journals across 69 medical subcategories. Our study bridges research in operations management, information systems, healthcare, and analytics by providing a definition of BA in healthcare and a road map for future research. Managerial implications: Our study provides a single source of information into operations- and analytics-related issues, such as wait times, admissions, hospital performance, etc., that scholars and administrators might use to rethink how specific processes are handled in hospitals. In addition, this work highlights how operations management research has addressed clinically important issues such as patient satisfaction, doctor ratings, readmission rates, mortality, efficiency, cost of care, and compliance with protocols of care, as all are represented in our sample. Another key contribution of our study is that we provide an interactive article analysis tool as a web application for scholars in hopes of facilitating research in this area. Supplemental Material: The e-companion is available at https://doi.org/10.1287/msom.2023.1192 .
Seroprevalence of anti-Lassa Virus IgG antibodies in three districts of Sierra Leone: A cross-sectional, population-based study
Authors: Grant Donald S. , Engel Emily J. , Roberts Yerkes Nicole , Kanneh Lansana , Koninga James , Gbakie Michael A. , Alhasan Foday , Kanneh Franklyn B. , Kanneh Ibrahim Mustapha , Kamara Fatima K. , Momoh Mambu , Yillah Mohamed S. , Foday Momoh , Okoli Adaora , Zeoli Ashley , Weldon Caroline , Bishop Christopher M. , Zheng Crystal , Hartnett Jessica , Chao Karissa , Shore Kayla , Melnik Lilia I. , Mucci Mallory , Bond Nell G. , Doyle Philip , Yenni Rachael , Podgorski Rachel , Ficenec Samuel C. , Moses Lina , Shaffer Jeffrey G. , Garry Robert F. , Schieffelin John S. 
Published: February 2023

Background
Lassa virus (LASV), the cause of the acute viral hemorrhagic illness Lassa fever (LF), is endemic in West Africa. Infections in humans occur mainly after exposure to infected excrement or urine of the rodent-host, Mastomys natalensis. The prevalence of exposure to LASV in Sierra Leone is crudely estimated and largely unknown. This cross-sectional study aimed to establish a baseline point seroprevalence of IgG antibodies to LASV in three administrative districts of Sierra Leone and identify potential risk factors for seropositivity and LASV exposure.

Methodology and principal findings
Between 2015 and 2018, over 10,642 participants from Kenema, Tonkolili, and Port Loko Districts were enrolled in this cross-sectional study. Previous LASV and LF epidemiological studies support classification of these districts as “endemic,” “emerging,” and “non-endemic”, respectively. Dried blood spot samples were tested for LASV antibodies by ELISA to determine the seropositivity of participants, indicating previous exposure to LASV. Surveys were administered to each participant to assess demographic and environmental factors associated with a higher risk of exposure to LASV. Overall seroprevalence for antibodies to LASV was 16.0%. In Kenema, Port Loko, and Tonkolili Districts, seroprevalences were 20.1%, 14.1%, and 10.6%, respectively. In a multivariate analysis, individuals were more likely to be LASV seropositive if they were living in Kenema District, regardless of sex, age, or occupation. Environmental factors contributed to an increased risk of LASV exposure, including poor housing construction and proximity to bushland, forested areas, and refuse.

Conclusions and significance
In this study we determine a baseline LASV seroprevalence in three districts which will inform future epidemiological, ecological, and clinical studies on LF and the LASV in Sierra Leone. The heterogeneity of the distribution of LASV and LF over both space, and time, can make the design of efficacy trials and intervention programs difficult. Having more studies on the prevalence of LASV and identifying potential hyper-endemic areas will greatly increase the awareness of LF and improve targeted control programs related to LASV.
Study for the validation of the FeetMe® integrated sensor insole system compared to GAITRite® system to assess gait characteristics in patients with multiple sclerosis
Authors: Granja Domínguez Anabel , Romero Sevilla Raúl , Alemán Aurora , Durán Carmen , Hochsprung Anja , Navarro Guillermo , Páramo Cristina , Venegas Ana , Lladonosa Ana , Ayuso Guillermo Izquierdo 
Published: February 2023

Objective
To determine the concordance and statistical precision in gait velocity in people with multiple sclerosis (pwMS), measured with FeetMe® (insoles with pressure and motion sensors) compared with GAITRite® (classic reference system of gait analysis) in the timed 25-Feet Walk test (T25WT).

Methods
This observational, cross-sectional, prospective, single center study was conducted between September-2018 and April-2019 in pwMS aged 18–55 years, with Expanded Disability Status Scale (EDSS) 0–6.5 and relapse free ≥30 days at baseline. Primary endpoint was gait velocity. Secondary endpoints were ambulation time, cadence, and stride length assessment, while the correlation between gait variables and the clinical parameters of MS subjects was assessed as an exploratory endpoint.

Results
A total of 207 MS subjects were enrolled, of whom, 205 were considered in primary analysis. Most subjects were women (66.8%) and had relapsing-remitting MS (RRMS) (82.9%), with overall mean (standard deviation [SD]) age of 41.5 (8.0) year and EDSS 3.1 (2.0). There was a statistically significant (p<0.0001) and strong agreement (intra-class correlation coefficient (ICC) >0.830) in gait velocity, ambulation time and cadence assessment between FeetMe® and GAITRite®.

Conclusions
Agreement between devices was strong (ICC≥0.800). FeetMe® is the first validated wearable medical device that allows gait monitoring in MS subjects, being potentially able to assess disease activity, progression, and treatment response.
A generalized classification and coding system of Human Disease Animal Model Resource data with a case study to show improving database retrieval efficiency
Authors: Li Huiping , Zhang Wenjuan 
Published: February 2023

BackgroundCurrently there is no unified data classification and coding standard for the existing human disease animal model resource data worldwide. Different data classification and coding systems produce different retrieval methods. Some of these methods are inefficient and difficult to use. This research investigated the rules for the classification and coding of such data based on theReplication Methodology of Animal Models for Human Disease, the Classification and Coding Rules for Health Information Data Set (WS/T 306–2009), the Science and Technology Resource Identification (GB/T 32843–2016), the Scientific Data Management Measures (000014349/2018-00052), andThe Generic Description Specification for Natural Science and Technology Resources. This research aimed to develop a classification and coding system for data obtained from human disease animal model resource based on the Internet environment to provide a standardized and unified foundation for the collection, saving, retrieval, and sharing of data from this resource.ResultsA complete data classification and coding table compiled in the form of letters and numbers was produced, with a classification infrastructure that expanded layer by layer according to the three dimensions (namely, system diseases, animal species, and modeling methods) and essential attributes. When necessary, it adopted the hierarchy of major, intermediate, and minor categories for certain layer and also one-to-one matched the code and classification result.ConclusionThrough this study, a sharing and joint construction mechanism for data from this resource can be developed by all research institutes in this field. As a case study, this research also offered technical support for constructing the database for the National Human Disease Animal Model Resource Center. The technological innovation of this paper is to derive a research oriented retrieval method, which provides technical support for the research on the current COVID-19 epidemic and on possible future epidemics.
Exploring the values, preferences, and information needs of patients with NKX2-1-related disorders: A qualitative study protocol
Authors: Martín-Gómez Carmen , Ortigoza-Escobar Juan Dario , Nou-Fontanet Laia , Molina-Linde Juan M. , Bachoud-Lévi Anne-Catherine , Léger Juliane , Blasco-Amaro Juan Antonio ,   NKX2-1-Related Disorders Guideline Working Group
Published: February 2023

Background
NKX2-1-related disorders have a prevalence of 1:500,000 and are therefore considered a rare condition according to the European Commission’s definition. The European Reference Network of Rare Neurological Disorders is developing the first clinical practice guideline on the management of this condition, with the support of the Andalusian Health Technology Assessment Area, Endo-ERN, ERN-Lung and Imegen, within the framework of the ERNs Guidelines programme (DG SANTE/2018/B3/030). Within the scope of this programme, it becomes necessary to explore the patient perspective in order to include it in the ongoing clinical practice guideline and accompanying patient information booklet.

Methods and analysis
This study will use qualitative methods to explore the values, preferences and information needs of patient with NKX2-1-related disorders and their caregivers. Participants will come from a variety of countries throughout Europe. One focus group and four semi-structured interviews will be conducted. Pairs will analyse the data using Grounded Theory. The Andalusian Regional Ministry of Health’s Ethics Coordinating Committee for Biomedical Research (Sevilla, Andalucía, Spain) has approved this study protocol (29/03/2022).

Discussion
This is the first study to explore the values, preferences, and information needs of patients with NKX2-1-related disorders. The proposed study’s findings will contribute to the generation of useful knowledge that will provide guidance to improve the care given to patients with the studied condition. While this study will provide valuable insights into the perspectives of patients with NKX2-1-related disorders, the findings are unlikely to be generalizable to patients with other conditions.
Theoretical step approach with ‘Three-pillar’ device assistance for successful endoscopic transpapillary gallbladder drainage
Authors: Yoshida Michihiro , Naitoh Itaru , Hayashi Kazuki , Hori Yasuki , Kato Akihisa , Kachi Kenta , Asano Go , Sahashi Hidenori , Toyohara Tadashi , Kuno Kayoko , Kito Yusuke , Kataoka Hiromi 
Published: February 2023

Background
Endoscopic transpapillary gallbladder drainage (ETGBD) has been reported as an alternative procedure for acute cholecystitis but remains a challenging procedure.

Aims
To elucidate the efficacy of a strategic approach for ETGBD that utilizes a four-step classification system and the optional use of ‘Three-pillar’ assistance with the following devices: cholangioscopy (SpyGlass DS, SG), a flex-type guidewire (Flex-GW), and a 3-Fr microcatheter (3-Fr Micro).

Methods
A total of 115 patients undergoing ETGBD were studied retrospectively. Characteristics and technical outcomes were compared between conventional ETGBD technique (Classical ETGBD, N = 50) and strategic ETGBD with optional Three-pillar assistance (Strategic ETGBD, N = 65).

Results
SG-assistance (15/65, 23.1%) was as an excellent troubleshooter in Category 1 (failure to identify the cystic duct [CD] orifice) and Category 2 (failure to advance the GW across the CD takeoff due to unfavorable angle). Flex-GW (19/65, 29.2%) worked for Category 3b (failure of GW access to the GB due to multiple tortuosities). 3-Fr Micro (11/65, 16.9%) was effective for Category 3a (failure of GW access to the GB due to CD obstruction) and Category 4 (failure of drainage stent insertion to the GB). The overall technical success rate was significantly higher for Strategic ETGBD (63/65, 96.9%) compared with Classical ETGBD (36/50, 72.0%) (p = 0.0001).

Conclusions
Strategic ETGBD, which includes the Three-pillar assistance options of SG in the initial steps, Flex-GW for tortuous CD, and 3-Fr Micro for stenotic CD, achieved a significantly higher success rate than for Classical ETGBD.
THE ROLE OF A PROFESSIONAL BUILDER IN FACILITY MANAGEMENT
Authors: Ezenwa Godfrey Chidozie 
Published: February 2023

ABSTRACT
This research studied the role of a Professional Builder in facility management. The researcher chose Awka and Onitsha in Anambra State as the area of study. This study was carried out so as to find out actually, if Professional Builders have a role to play in facility management and identify those roles. In carrying out the study, related literature in the study were reviewed, primary data were collected using questionnaires, while data obtained were analyzed using frequency table and simple percentages and hypothesis were tested using Z-test statistical tools. Some of the findings and recommendations in this research study are: The researcher observed that facility management is not well known and not properly practiced in this part of the world, the issue of which professional should lay claim to facility management service is not properly defined in the minds of people, the role of professionals as a facility manager is not well known. As a result of all these, a proper awareness should be carried out so as to enable organizations engage professional Builders for facility management services, in order to meet organizational goals.
Patients With Crohn's Disease and Permanent Ileostomy Are Universally Excluded From Clinical Trials: A Systematic Review
Authors: Vuyyuru Sudheer K. , Rieder Florian , Solitano Virginia , Nguyen Tran M. , Crowley Eileen , Narula Neeraj , Singh Siddharth , Ma Christopher , Jairath Vipul 
Published: February 2023

INTRODUCTION:
We performed a systematic review to investigate whether patients with Crohn's disease (CD) and permanent ileostomy (PI) have been included in clinical trials evaluating biologics and small molecules.

METHODS:
MEDLINE, Embase and Cochrane library (CENTRAL) data bases were searched from inception to May 16, 2022 for placebo controlled induction and/or maintenance randomized controlled trials assessing biologics and oral small molecules in adult patients with active CD.

RESULTS:
Of the 81 induction and maintenance trials assessing biologics and oral small molecules in CD, none permitted the enrollment of patients with PI. Patients with CD and PI have been universally excluded from pharmaceutical trials of biologics and small molecules to date.

DISCUSSION:
There is an urgent need to identify barriers to enrollment and develop eligibility and outcome measures enabling the inclusion of patients with CD and PI into clinical trials.
Appendiceal Fecalith Presenting as a Submucosal Cecal Polyp Removed During Colonoscopy
Authors: Payne Kaitlin , Farha Natalie , Savage Erica , Burke Carol A. 
Published: February 2023

ABSTRACT
Appendiceal fecaliths, also known as stercoliths or coproliths, are rigid masses comprised of fecal material that become lodged within the appendix. They are generally accepted to be a primary etiologic agent of acute appendicitis and appendiceal intussusception in adults. We report a case of an asymptomatic woman undergoing colonoscopy found to have a submucosal appearing mass below the appendiceal orifice. A neoplastic appearing lesion on the orifice of the appendix was resected, after which a fecalith extruded into the colonic lumen. This is the first reported case of appendiceal fecalith discovered and completely removed during colonoscopy in an asymptomatic patient.
Relationship between severe acute respiratory syndrome coronavirus 2 and diabetes mellitus (review)
Authors: Artykbaeva G. M. , Saatov T. S. 
Published: February 2023

Infections caused by SARE-CoV-2 are complicated with the concurrent pathologies, to name hypertension, diabetes mellitus and cardiovascular diseases. High level of glucose in blood weakens the immunity and increase the SARS-CoV-2 replication. Diabetes mellitus aggravates the COVID-19 outcome. The intrusion of SARS-CoV-2 into a host-cell occurs by means of its association with the angiotensin-converting enzyme-2 (ACE 2). Stimulating immune responses the COVID-19 infection causes the cytokine storm, and may result in the lethal outcome in the diabetics.Recent laboratory studies demonstrated that the type1 and type2 diabetes mellitus is the main consequence in 14% of the patients after corona infection. Thus, in 2% of 14% diabetes started progressing due to the corona virus. In the other, diabetes debut occurred as the direct and negative consequence of the disease. Hyperglycemia results in the formation of protein molecules known as the advanced glycation end products (AGEs). The AGEs and their receptors (RAGE) are of high significance in the host-cell’s virus invasion. Consequently, more strict glucose control is necessary for optimal outcome and reduction in mortality. The better control for the COVID-19 course can be provided by the targeted effect on the RAGE axis. The review helps elucidate the molecular mechanism underlying the exacerbation of pathophysiology in the diabetic COVID-19 patients.
Paradoxes of the Canadian mosaic: “being, feeling and doing Canadian”
Authors: Nystrom Gloria 
Published: February 2023

Abstract
This autoethnographic narrative shows how discourses of belonging for racialized identities within Canada’s mosaic are bounded by history, cultural politics, and attendant social struggles. Using an intersectional framework of Asian Critical theory, politics of location, and cultural capital, this paper demonstrates how ideologies of belonging are sustained by processes of cultural and institutional socialization which maintain hierarchies privileging some social groups over others and produce racial/ized difference and inequities within Canadian citizenry. As a second-generation of Chinese ancestry born and raised in Vancouver, Canada, my lived experiences in a predominantly white English-speaking environment illustrate how my status as “model minority” or “honorary white” has been a precarious position. Bonilla-Silva warns us that “honorary white” positioning may be revoked in times of economic, racial or ethnic tension. Dramatic increases in anti-Asian hate incidents during the 2020 Coronavirus pandemic—earning Vancouver, BC, the title of the “anti-Asian hate capital of North America”—is an example of how these racialized statuses are paradoxical designations which deny the existence of social inequities. Critical research must interrogate how the continued use of mis-aggregated data that essentializes diverse population groups and perpetuates harmful distortions of Canadian citizenry contribute to, rather than dismantle, discourses of race in “multicultural” Canada.