bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mechanistic Elucidations of Highly Dispersed Metalloporphyrin Metal‐Organic Framework Catalysts for CO2Electroreduction
Authors: Smith Michael R. , Martin Clare B. , Arumuganainar Sonia , Gilman Ari , Koel Bruce E. , Sarazen Michele L. 
Published: December 2022

AbstractImmobilization of porphyrin complexes into crystalline metal–organic frameworks (MOFs) enables high exposure of porphyrin active sites for CO2electroreduction. Herein, well‐dispersed iron‐porphyrin‐based MOF (PCN‐222(Fe)) on carbon‐based electrodes revealed optimal turnover frequencies for CO2electroreduction to CO at 1 wt.% catalyst loading, beyond which the intrinsic catalyst activity declined due to CO2mass transport limitations. In situ Raman suggested that PCN‐222(Fe) maintained its structure under electrochemical bias, permitting mechanistic investigations. These revealed a stepwise electron transfer‐proton transfer mechanism for CO2electroreduction on PCN‐222(Fe) electrodes, which followed a shift from a rate‐limiting electron transfer to CO2mass transfer as the potential increased from −0.6 V to −1.0 V vs. RHE. Our results demonstrate how intrinsic catalytic investigations and in situ spectroscopy are needed to elucidate CO2electroreduction mechanisms on PCN‐222(Fe) MOFs.
Synthetic K+Channels Constructed by Rebuilding the Core Modules of Natural K+Channels in an Artificial System
Authors: Xin Pengyang , Xu Linqi , Dong Wenpei , Mao Linlin , Guo Jingjing , Bi Jingjing , Zhang Shouwei , Pei Yan , Chen Chang‐Po 
Published: December 2022

AbstractDifferent types of natural K+channels share similar core modules and cation permeability characteristics. In this study, we have developed novel artificial K+channels by rebuilding the core modules of natural K+channels in artificial systems. All the channels displayed high selectivity for K+over Na+and exhibited a selectivity sequence of K+≈Rb+during the transport process, which is highly consistent with the cation permeability characteristics of natural K+channels. More importantly, these artificial channels could be efficiently inserted into cell membranes and mediate the transmembrane transport of K+, disrupting the cellular K+homeostasis and eventually triggering the apoptosis of cells. These findings demonstrate that, by rebuilding the core modules of natural K+channels in artificial systems, the structures, transport behaviors, and physiological functions of natural K+channels can be mimicked in synthetic channels.
Helical β‐isoindigo‐Based Chromophores with B−O−B Bridge: Facile Synthesis and Tunable Near‐Infrared Circularly Polarized Luminescence
Authors: Xu Yongqiang , Ni Zhigang , Xiao Yao , Chen Ziwei , Wang Sisi , Gai Lizhi , Zheng You‐Xuan , Shen Zhen , Lu Hua , Guo Zijian 
Published: December 2022

AbstractIt is essential to create organic compounds that exhibit circularly polarized luminescence (CPL) in the near‐infrared (NIR) range. Helicene‐type emitters possess appealing chiroptical features, however, such NIR molecules are scarce due to a paucity of synthetic strategies. Herein, we developed a series of helical β‐isoindigo‐based B−O−B bridged aza‐BODIPY analogs that were synthesized conveniently. The reaction of diimino‐β‐isoindigo with a heteroaromatic amine produced a restricted ligand cavity, which triggered off the generation of a B−O−B bridge. The B−O−B bridge led to distorted conformations that satisfy the helical requirements, resulting in excellent spectroscopic and chiroptical properties. Tunable CPL with the highest luminescence dissymmetry factor (glum) of 1.3×10−3and a CPL brightness (BCPL=11.5 M−1 cm−1) in the NIR region was achieved. This synthetic approach is expected to offer a new opportunity to chiral chemistry and increase flexibility for chiroptical tuning.
Direct Detection of FeVI Water Oxidation Intermediates in an Aqueous Solution
Authors: Feng Chao , She Xianghua , Xiao Yequan , Li Yanbo 
Published: December 2022

AbstractIn situ detection of highly‐oxidized metal intermediates is the key to identifying the active center of an oxygen evolution reaction (OER) catalyst, but it remains challenging for NiFe‐based catalysts in an aqueous solution under working conditions. Here, by utilizing the dynamic stability of the FeVIO42− intermediates in a self‐healing water oxidation cycle of NiFe‐based catalyst, the highly‐oxidized FeVI intermediates leached into the electrolyte are directly detected by simple spectroelectrochemistry. Our results provide direct evidence that Fe is the active center in NiFe‐based OER catalysts. Furthermore, it is revealed that the incorporation of Co into NiFe‐based catalyst facilitates the formation of FeVI active species, thus enhancing the OER activity of NiCoFe‐based catalyst. The insights into the mechanisms for the sustainable generation of FeVI active species in these NiFe‐based catalysts lay the foundation for the design of more efficient and stable OER catalysts.
The role of organoclay in the diffusion of epoxy‐amine oligomers and in the cross‐linking density of the resulting network
Authors: Baruel Amanda F. , Dutra Rita C. L. , Diniz Milton F. , Azevedo Margarete F. P. , Cassu Silvana N. 
Published: December 2022

AbstractEpoxy nanocomposites are promising for adhesive applications due to their high performance. In this work, an organoclay (PO), prepared by cationic exchanging using a quaternary phosphonium salt or a silylated PO (SPO) was added to an epoxy‐amine resin‐based adhesive to reduce its dripping. PO and SPO were dispersed in the epoxy network on a nanometric scale, mainly in an intercalated structure. A liquid‐to‐gel transition occurs at 4–6 wt% PO due to forming a continuous organoclay network throughout the epoxy volume, eliminating its dripping. The PO addition accelerates the curing reaction initially, and cured nanocomposites with over 3 wt% PO show a drastic reduction in the glass transition temperature (Tg). Moreover, a broadening of the secondary relaxation observed by DMA indicates an interaction between the epoxide‐amine oligomers with the silicate surface. This interaction, associated with forming a continuous organoclay network at 4–6 wt% PO, reduces the epoxy‐amine oligomers diffusion, resulting in their partial curing and consequent Tg decreasing. EPOXY_SPO nanocomposites show Tg values similar to or higher than that observed for the epoxy‐amine network attributed to the forming of covalent bonds between the glycidyloxypropyl end groups in the SPO surface and the hardener amine.
Reinforcing and plasticizing effects of reclaimed rubber on the vulcanization and properties of natural rubber
Authors: Ren Teng , Song Pan , Yang Wei , Formela Krzysztof , Wang Shifeng 
Published: December 2022

AbstractThe production of high‐added value reclaimed rubber (RR) is of great significance for the sustainability of rubber industries. To green recycle waste rubbers and broaden the application of RR, a RR material with potential reinforcing and plasticizing effects on nature rubber (NR) composites are prepared by a thermo‐oxidative reclamation process. The reclamation degree of RR is controlled by adjusting the content of soybean oil. The plasticizing effect is demonstrated by the decrease of torque during vulcanization and the enhancement of elongation at break of NR/RR composites with the increasing reclamation of RR. The tensile strength of NR/RR composites is enhanced by adding the RR, and the existence of RR also improves the thermal stability and rheological properties of NR/RR composites. The formation of new bound rubber in NR/RR compound indicates the reinforcing ability of RR. In addition, the average particle size of RR reaches nano‐scale according to scanning electron microscope photographs and its dispersion in NR/RR compounds is improved with the increasing reclamation degree of RR as shown in Payne effect. This work demonstrates the reinforcing and plasticizing ability of the RR, which is beneficial to improving the added value of reclaimed and broadening its application.
Determination of vitamin B12 in commercial pepsin preparations using immunoaffinity chromatography and LC‐MS/MS
Authors: Lenz Tamara , Maxones Alexander , Pichner Rohtraud , Birringer Marc 
Published: December 2022

AbstractVitamin B12 is a critical micronutrient in a vegan diet and thus dietary sources are limited and often low in the vitamin. Analytical determination of vitamin B12 requires laborious sample preparations including the proteolytic breakdown of the (food) matrix with proteases and the enrichment of the vitamin via immunoaffinity methods. Proteases like pepsin have an animal origin and thus might contain significant amounts of vitamin B12. We hypothesize that pepsin preparations potentially transfer residual vitamin B12 into the sample and falsify results. Hence the aim of our study was to determine trace amounts of cyano‐cobalamin by LC‐MS/MS in commercial protease enzyme preparations. The use of a stable 15N‐labeled cyano‐cobalamin as internal standard enabled us to detect vitamin B12 with a LOQ as low as 0.7 µg/l. Significant amounts of the vitamin were found in pepsin whereas the vitamin B12 content of papain preparations was below the detection limit. We conclude that sample preparation with pepsin bears the risk of false positive results, especially for samples with low vitamin B12 content, and we therefore recommend papain as an alternative protease for food sample preparation.
Drivers and barriers for circular business model innovation
Authors: Geissdoerfer Martin , Santa‐Maria Tomas , Kirchherr Julian , Pelzeter Carla 
Published: December 2022

AbstractThe circular economy concept is gaining traction in academia, industry and policymaking as a strategy to reduce resource depletion, waste and emissions. Many authors see business model innovation as a critical lever for the concept's implementation on the organisational level. Despite the importance of the topic, the drivers and barriers to different types of circular business model innovation remain unclear. We address this gap by comparing drivers and barriers for four generic circular business model innovation types: start‐up, diversification, transformation and acquisition. Relying on a structured comparative literature review using cross‐reference searches, we develop a theoretical framework of drivers and barriers that we apply to a multi‐case study of 21 organisations covering three of the four types, with some additional insights on the fourth. We identify 25 barriers and 10 drivers, clustered into seven categories, and outline how they distinctively affect the innovation types. Start‐ups and diversifications are more commonly driven by market and financial factors, while transformations are led by market and organisational factors. These three types are highly affected by legal and financial barriers; however, while start‐ups are more prone to face value chain challenges, incumbents are more susceptible to market and organisational barriers. Our study provides novel empirical data that validate and complement previous research and offers an additional analysis perspective in the transition towards a more sustainable and circular economy.
Chimeric antigen receptor T (CAR‐T) cells: Novel cell therapy for hematological malignancies
Authors: Abbasi Samane , Totmaj Milad Asghari , Abbasi Masoumeh , Hajazimian Saba , Goleij Pouya , Behroozi Javad , Shademan Behrouz , Isazadeh Alireza , Baradaran Behzad 
Published: December 2022

AbstractOver the last decade, the emergence of several novel therapeutic approaches has changed the therapeutic perspective of human malignancies. Adoptive immunotherapy through chimeric antigen receptor T cell (CAR‐T), which includes the engineering of T cells to recognize tumor‐specific membrane antigens and, as a result, death of cancer cells, has created various clinical benefits for the treatment of several human malignancies. In particular, CAR‐T‐cell‐based immunotherapy is known as a critical approach for the treatment of patients with hematological malignancies such as acute lymphoblastic leukemia (ALL), multiple myeloma (MM), chronic lymphocytic leukemia (CLL), acute myeloid leukemia (AML), Hodgkin lymphoma (HL), and non‐Hodgkin's lymphoma (NHL). However, CAR‐T‐cell therapy of hematological malignancies is associated with various side effects. There are still extensive challenges in association with further progress of this therapeutic approach, from manufacturing and engineering issues to limitations of applications and serious toxicities. Therefore, further studies are required to enhance efficacy and minimize adverse events. In the current review, we summarize the development of CAR‐T‐cell‐based immunotherapy and current clinical antitumor applications to treat hematological malignancies. Furthermore, we will mention the current advantages, disadvantages, challenges, and therapeutic limitations of CAR‐T‐cell therapy.
LncRNA DNAJC3‐AS1 promotes the biological functions of papillary thyroid carcinoma via regulating the microRNA‐27a‐3p/CCBE1 axis
Authors: Ni Tiangen , Li Yongyong , Guo Dan , Tan Ling , Xiao Zhesi , Shi Yanjie 
Published: December 2022

AbstractLong noncoding RNA DNAJC3‐AS1 (lncRNA DNAJC3‐AS1) has been probed in many studies, while the regulatory mechanism of DNAJC3‐AS1 on papillary thyroid carcinoma (PTC) via regulating microRNA (miR)‐27a‐3p remains inadequate. This research aims to depict the role of DNAJC3‐AS1, miR‐27a‐3p, collagen, and calcium‐binding EGF domain‐containing protein 1 (CCBE1) on PTC development. DNAJC3‐AS1, miR‐27a‐3p, and CCBE1 expression levels in PTC tissues and adjacent normal tissues were tested. The relation of DNAJC3‐AS1, miR‐27a‐3p, and CCBE1 was analyzed. DNAJC3‐AS1 and miR‐27a‐3p and CCBE1‐related oligonucleotides were transfected into IHH‐4 cells to investigate their role in PTC development. Cell tumorigenicity was detected by in vivo assay. DNAJC3‐AS1 and CCBE1 expressed highly and miR‐27a‐3p expressed lowly in PTC. Downregulation of DNAJC3‐AS1, upregulating miR‐27a‐3p or downregulating CCBE1 impaired the malignant behaviors of IHH‐4 cells. Depletion of miR‐27a‐3p reversed the DNAJC3‐AS1 suppression‐induced phenotypic inhibition of IHH‐4 cells. DNAJC3‐AS1 bound to miR‐27a‐3p and CCBE1 as a target of miR‐27a‐3p. Our study highlights that DNAJC3‐AS1 inhibits miR‐27a‐3p to promote CCBE1 expression, thereby facilitating PTC development. This study affords distinguished therapeutic strategies and novel research directions for PTC treatment.
Construction of Aluminum‐Porphyrin‐Based Hypercrosslinked Ionic Polymers (HIPs) by Direct Knitting Approach for CO2 Capture and In‐Situ Conversion to Cyclic Carbonates
Authors: Xu Wei , Chen Min , Yang Yiying , Chen Kechi , Li Yingyin , Zhang Zixuan , Luo Rongchang 
Published: December 2022

AbstractHypercrosslinked polymers (HCPs) constructed by Friedel‐Crafts reaction have drawn increasing attention in recent decades, but their multifunctionalization remains a huge challenge. Herein, a series of aluminum‐porphyrin‐based hypercrosslinked ionic polymers have been successfully synthesized by direct knitting approach without additional electrophilic comonomers, which involves the copolymerization of neutral porphyrin monomers and ionic building. By increasing the connected nodes numbers of ionic monomers, the introduction of abundant tetraphenylmethane fragements into the porphyrin backbones endows them with high‐density ionic active sites. Accordingly, the well‐matched molar ratios of aluminum sites to nucleophilic chloride anions that work synergistically for CO2/epoxide coupling can be achieved. Al‐HIP‐2 with flexible ionic pendants and a high Al/Cl ratio allows CO2 cycloaddition to be performed at ambient conditions or with diluted CO2; while Al‐HIP‐3 with rigid ionic moieties and a relatively low Al/Cl ratio exhibits higher specific surface area and stronger CO2 capture ability. Therefore, this co‐condensation strategy provides a simple and feasible pathway for adjusting the reactivity ratios of comonomers via simple structural changes in the knitting process, thus achieving the rational construction of multifunctionalized HCPs for CO2 capture and in‐situ conversion to cyclic carbonates.
ETNK1 mutation occurs in a wide spectrum of myeloid neoplasms and is not specific for atypical chronic myeloid leukemia
Authors: Shuai Wen , Zuo Zhuang , Li Nianyi , Garces Sofia , Jelloul Fatima Zahra , Ok Chi Young , Li Shaoying , Xu Jie , You M. James , Wang Wei , Rehder Catherine , Jabbour Elias J. , Patel Keyur P. , Medeiros L. Jeffrey , Yin C. Cameron 
Published: December 2022

AbstractBackgroundETNK1 mutation has been suggested as a useful tool to support the diagnosis of atypical chronic myeloid leukemia. ETNK1 mutations, however, occur in other myeloid neoplasms.MethodsThe authors assessed the clinicopathologic and molecular genetic features of 80 ETNK1‐mutated myeloid neoplasms.ResultsThirty‐seven neoplasms (46%) were classified as myelodysplastic syndrome, 17 (21%) were classified as myelodysplastic/myeloproliferative neoplasm, 14 (18%) were classified as acute myeloid leukemia, and 12 (15%) were classified as myeloproliferative neoplasm. ETNK1 mutations were detected at the first test in 96% of patients, suggesting that ETNK1 mutation is an early event in pathogenesis. ETNK1 mutations represented the dominant clone in 63% of patients and was persistently dominant in 93%. The variant allele frequencies were usually higher in acute myeloid leukemia and increased upon leukemic transformation. ETNK1 mutation was accompanied by coexisting mutations in all patients, with ASXL1 (50%), TET2 (25%), EZH2 (24%), RUNX1 (24%), and SRSF2 (24%) mutations being the most common. Neoplasms with ETNK1 mutations were associated with morphologic dysplasia, increased blasts, myelofibrosis, and noncomplex karyotypes. With a median follow‐up of 16.5 months, 30 patients died, 44 had persistent disease, and four achieved complete remission after stem cell transplantation.ConclusionsETNK1 mutation is present in various myeloid neoplasms, often as an early event and a dominant clone and always with concurrent mutations. It may play an important role in the pathogenesis and progression of myeloid neoplasms by causing DNA damage and inducing other mutations and genomic instability, and it may serve as a potential therapeutic target. ETNK1 mutation is not disease‐specific and should be interpreted with caution to classify myeloid neoplasms.
Silicon‐Based Composite Anodes for All‐Solid‐State Lithium‐Ion Batteries Conceived by a Mixture Design Approach
Authors: Branchi Mario , Maresca Giovanna , Tsurumaki Akiko , Suzuki Naoki , Croce Fausto , Panero Stefania , Voje Jorunn , Aihara Yuichi , Navarra Maria Assunta 
Published: December 2022

AbstractSilicon‐based anodes composed of micrometric Si, graphite (MAG), LiI−Li3PS4solid electrolyte (LPSI), and carbon nanofiber (CNF), which can be prepared by straightforward manual grinding, are proposed in this study. The relation between composition and performance of the anodes is investigated through the mixture design approach, which allows discrimination of the effect of each component and also the combined effect of the components on the end performance. By increasing the fraction of LPSI in the anode, the capacity of the electrode is improved, and the best performance is obtained when the Si/MAG/LPSI ratio is 15 : 15 : 70. This composite integrated with 5 wt % CNF exhibits a capacity above 1200 mAh g−1throughout 50 cycles in a bulk‐type all‐solid‐state battery with LPSI as the electrolyte. Scanning electron microscopy (SEM) confirms that the presence of LPSI suppresses the aggregation of Si and improves the ratio of Si available for lithiation/delithiation.
Energy, exergy and exergoeconomic (3E's) analysis of simmering type cooking using evacuated tube collector
Authors: Chaudhary Ranjan , Mehla Neeraj , Kumar Amit , Yadav Avadhesh 
Published: December 2022

AbstractA solar cooking system is investigated for the simmering type of cooking using slow heating cooking pot (SHCP) and evacuated tube collector (EVTC). The thermic oil used as heat transfer fluid (HTF) is utilized to convey heat from the solar collector to SHCP. Indian cuisine items like Khoa and Kheer are cooked by using simmering method of cooking. The cooking load is varied from 1 to 2.5 L for khoa preparation and 2 to 2.8 L load is varied for kheer preparation. The cooking is done by utilizing the thermal energy of thermic oil flowing inside the SHCP and its average energy and exergy efficiency is evaluated which varies from ~0.20 to around 0.30 and 0.15 to 0.20, respectively. The payback period of the presented solar cooking system is 3.45 years.
1st European Symposium on Phytochemicals in Medicine and Food—Insight into the conference
Authors: Popović‐Djordjević Jelena B. 
Published: December 2022

AbstractThe University of Belgrade was chosen to host an international conference “1st European Symposium on Phytochemicals in Medicine and Food”, that was successfully held on 7–9. September 2022 in Belgrade, the capital city of Serbia. The main goals of the conference were to promote the scientific achievements of researchers in the field of natural products and their implementation in food and medicine, as well as to bring together well recognized scientists from all around the world and young researchers that are starting their careers in the research fields covered by the conference topics. In that respect 1‐EuSPMF fulfilled the expectations of the participants and the organizers.
Programmed death‐ligand 1 expression in Epstein‐Barr virus positive nasopharyngeal cancer
Authors: Alfagih Abdulhameed , Rahman Muhammad Amin Ur , Al‐Dandan Sadeq , Alrehaili Salem , Wani Tariq , Malki Abdulrahim Al , Zahrani Ali Al , Bakhribah Hatoon 
Published: December 2022

AbstractNasopharyngeal cancer (NPC) is common in Saudi Arabia; Most cases are related to the Epstein‐Barr virus (EBV), which is associated with treatment failure and a high recurrence rate. Programmed cell death protein 1 (PD‐1) and Programmed death‐ligand 1 (PD‐L1) inhibitors emerged as breakthroughs in cancer treatment, including head and neck cancers. The benefit of these therapies was seen in patients with high expression of PD‐L1, which is unknown in our population. We aim to assess PD‐L1 expression in EBV‐related NPC patients presented to King Fahd Medical City (KFMC). We identified 41 cases of EBV‐related NPC diagnosed between 2016 and 2019. PD‐L1 expression was assessed using the Tumor Proportion Score (TPS) and Combined Positive Scores (CPS). Results showed that PD‐L1 expression was negative in 51% and 29% using TPS and CPS scores, respectively. High expression of PD‐L1, more than 50%, was seen in 17% using TPS and 22% using CPS. There was no statistically significant correlation between the degree of PD‐L1 expression by TPS or CPS and many variables, including gender, comorbidities, BMI, TNM staging, and smoking status. Over a median follow‐up of 29.7 months, Kaplan‐Meier survival curves did not show a statistically significant difference between all groups of PD‐L1 expression for O.S. or PFS; However, there were shorter O.S noted with CPS 1%–9%, log‐rank p‐value = 0.031. These findings support investigating the role of Immunotherapy, especially in the high expression subgroup. Data for these patients' outcomes and further studies to explore the role of PD‐L1 in NPC are needed.