bluuebunny/crossref_metadata_2025_split huggingface dataset:
Application of suprapsular phacoemulsification in patients with high myopia and cataract surgery
Authors: Zhu zicheng , Wang Lisong , Wang Zeyu , Han Jin 
Published: April 2023

Abstract
Purpose：To compare and evaluate the differences in the therapeutic effects of different surgical methods for treating high myopia cataracts using supracapsular phacoemulsification technology and intracapsular phacoemulsification respectively, and to provide a basis for choosing the best surgical method.
Methods: A total of 240 patients (268 eyes) with high myopia and cataract who underwent cataract surgery in our hospital from December 2020 to May 2022 were enrolled,of which 120 patients (136 eyes) were selected as the supracapsular phacoemulsification group, and 120 patients (132 eyes) as the intracapsular phacoemulsification group.The intraoperative average ultrasonic energy (AVE), effective phacoemulsification time (EPT), intraoperative complications, postoperative 1d, 1mo visual acuity and the corneal endothelial cell counts were recorded and compared.
Results:Comparing the subgroups with the same nuclear hardness between the two groups, the AVE and EPT of the supracapsular group were lower than those of the intracapsular group, and the difference was significant(P＜0.05). Postoperative 1 mo UCVA and BCVA between two groups were significantly higher than those of postoperative 1d, and the difference was statistically significant (P<0.05). Posterior capsular rupture occurred in 0 eyes in the supracapsular group and6 eyes in the intracapsular group.There were no other serious surgical complications.
Conclusion:The supracapsular method is simpler than the intracapsular phacoemulsification technique, uses less energy, takes less time, and has fewer complications.Therefore, Therefore, the results of this study support the use of supracapsular method for phacoemulsification cataract surgery in myopes.
Ulnar longitudinal deficiency; type D of Cole and Manske’s classification and type V of Goldfarb’s: A case report
Authors: Abdollahi Amirsaleh , Kadkhodaee Rouzbeh , amrehi Abolfazl Ghadiri , Zamani Sina , Pahnabi Ali , Rezaee Ali 
Published: April 2023

Abstract
Background Ulnar longitudinal deficiency (ULD) has been reported to be 1 in 100,000 live birthsCase presentation a 57-year-old healthy man with a fracture of the right medial malleolus was referred to our Orthopedic Center. Upon physical examination, a congenital abnormality in the patient's right upper extremity was observed. It was markedly shortened, pronated, and internally rotated. Radiological investigations revealed radiohumeral synostosis along with a complete absence of ulna and carpal bones, as well as shortened and bowed radius. Besides, only the thumb and the first metacarpal bone were present in the hand, and the wrist deviated towards the ulna. Taking into account the patient’s clinical findingsConclusion it is concluded that he likely falls under type D of Cole and Manske’s classification and type V of Goldfarb’s.
Joint Optimization between Task Offloading and Resource Allocation in Mobile Edge Computing with multiple UAVs
Authors: Chen Rujie , Gao Yang , Zou Dikai , Chen Xinyu , Tao Jun 
Published: April 2023

Abstract
Energy consumption and completion time are two hot issues in UAV (Unmanned Aerial Vehicles) assisted edge computing.The current research is mainly focused on the interaction between UAVs and edge servers, while the interplay between UAVs is rarely considered.In this paper, in the considered scenario with multiple UAVs and servers, the UAVs may possess idle resources, and thus function as temporary servers to provide task offloading services for other UAVs.We begin by formulating a multi-objective joint optimization problem, which aims to balance the energy consumption and time delay in order to maximize the benefits of the system. Then we use a multi-objective genetic algorithm called Non-dominated Sorting Genetic Algorithm II (NSGA-II) to iteratively find the optimal offloading strategy.Through numerical simulation, the results obtained from the numerical simulation demonstrate the superiority of the proposed method in achieving the Pareto optimal frontier that balances energy consumption and completion time.
CYP4A11/20-HETE induces oxidative stress and inhibits trophoblast proliferation via the PI3K/AKT signaling pathway during preeclampsia
Authors: Xu Huangfang , Zhao Huanqiang , Jiang Nanxing , Lu Huiqing , Ma Bo , Sun Yi , Wu Suwen , Zhou Qiongjie , Xiong Yu , Li Xiaotian 
Published: April 2023

Abstract
Background Placental oxidative stress injury is considered to be a key cause of preeclampsia, but the specific molecules that regulate the balance between oxidant and antioxidant levels remain unclear. 20-Hydroxyeicosatetraenoic acid (20-HETE), an important cytochrome P450 family 4 subfamily A polypeptide 11 (CYP4A11)-dependent eicosanoids, has been proved to increase reactive oxygen species production. Whether CYP4A11/20-HETE is involved in the regulation of oxidant or antioxidant levels in preeclamptic placenta is worth exploring.Methods The expressions of CYP4A11/20-HETE and redox related agents in placentas from pregnant women with and without preeclampsia were compared. Cellular lentiviral transfection was used to assess the effect of altered CYP4A11/20-HETE metabolism on oxidative stress and proliferation of trophoblasts, and RNA sequencing was taken to search its underlying mechanisms. Besides, in vivo animal experiments were arranged to verify whether Cyp4a10 (a protein that is highly homologous to human CYP4A11) overloaded lentivirus could induce preeclampsia-like symptoms in pregnant mice.Results The levels of CYP4A11/20-HETE were elevated in placentas from preeclamptic patients, and its expression was strongly associated with the expression of oxidative stress-related genes in the placentas. In vitro, CYP4A11/20-HETE overexpression caused oxidative stress injury and inhibited the proliferation of trophoblasts by suppressing the PI3K/AKT signaling pathway, and these effects were ameliorated by the pretreatment with the PI3K agonist 740 Y-P. In vivo, upregulation of Cyp4a10 (a protein that is highly homologous to human CYP4A11) during the placentation period caused hypertension and proteinuria in pregnant mice, presumably by impairing the placental antioxidant capacity and disrupting trophoblast proliferation.Conclusion This study identified CYP4A11/20-HETE as a potential causative factor of preeclampsia, which provide new insights into the pathogenesis of preeclampsia and may open a novel chapter for the future treatment strategies of preeclampsia.
The Neural Mechanism of Communication Between Graduate Students and Advisers in Different Adviser-advisee Relationships
Authors: Zhang Yan , Xie Simiao , Hou Yan , Wu Peipei , Wu Huifen 
Published: April 2023

Abstract
Communication is crucial in constructing the relationship between students and advisers, ultimately bridging interpersonal interactions. Only a few studies however explore the communication between postgraduate students and advisers. This study uses functional near-infrared spectroscopy (FNIRS) techniques to explore the neurophysiology differences in brain activation of postgraduates with different adviser-advise relationships during simulated communication with their advisers. Results showed significant differences in the activation of the prefrontal cortex between high-quality and the low-quality students during simulating and when communicating with advisers, specifically in the Broca's areas, the frontal pole, and the orbitofrontal and dorsolateral prefrontal cortices. This further elucidated the complex cognitive process of communication between graduate students and advisers.
Comprehensive Analysis Between Ferroptosis-Related Gene Signatures and Neuroblastoma Prognosis
Authors: Liu Xingyu , Zhang Lijie , Li Yuhan , Zhao Xu , Zhou Kai , Shen Qiyang 
Published: April 2023

Abstract
Background Neuroblastoma (NB) is one of the most common extracranial malignancies in central nervous system, threatening children’s health. It is an embryonic neural crest cell-derived pediatric solid tumor, usually resulting in tumors in the adrenal glands or the sympathetic ganglia. The clinical presentation can be quite heterogeneous, ranging from asymptomatic incidental tumors to widespread metastases with systemic manifestations. While children diagnosed with clinically stable NB can be completely cured, those with high-risk NB have a poor prognosis despite combination therapy strategies. In order to assess the prognosis of NB patients, sensitive biomarkers are worthy of in-depth study.Methods We obtain raw data from TARGET and GEO databases. Next, the role of ferroptosis death-related genes (FRGs) as a prognostic biomarker for NB patients was discussed. And Pearson correlation analysis and Cox regression analysis were used to select FRGs related to prognosis.Results Five genes were selected to construct a prognostic prediction model in the TARGET cohort. The risk score was calculated based on 5 FRGs. And according to the median value of risk score, patients were divided into low-risk group and high-risk group. The high-risk group has relatively higher abundance among immune cells. The expression of immuno-oncology target is up-regulated in patients with high-risk scores. In addition, the high-risk group is more related to oxidative phosphorylation and MTORC1 signaling. And to assess the overall survival (OS) of NB patients, a nomogram (based on MKI, COG risk group and risk score) was also established.Conclusion FRGs can be used as sensitive biomarkers to predict the prognosis of NB patients, and can be used in clinical immunotherapy and targeted therapy.
Determination of polyphenolic compounds in lucerne by supercritical fluid extraction coupled with ultra‑performance liquid chromatography‑tandem mass spectrometry
Authors: Walczak-Skierska Justyna , Krakowska-Sieprawska Aneta , Rafińska Katarzyna 
Published: April 2023

Abstract
A method was developed to determine 23 biologically active compounds, including 13 flavonoids and 10 phenolic acids, in various morphological parts (flowers, leaves, stems, seeds, and roots I and III cut) of the lucerne plant using a simple, fast high performance liquid chromatography with tandem mass spectrometry detection. The separation was achieved using a pentafluorophenyl stationary phase and a gradient elution with 0.1% formic acid in water and acetonitrile. The calibration curves exhibited good linearity (r2 value from 1.0 to 0.9925). The limit of detection (LOD) and limit of quantification (LOQ) for 23 compounds range from 0.01-50 ng/mL and 0.033-165 ng/mL, respectively. The main flavonoids found in the extracts were apigenin (765.96 ± 29.08 µg/g), luteolin (545.21 ± 14.64 µg/g), quercetin (169.90 ± 16.69 µg/g), and esculetin (130.99 ± 6.72 µg/g). Salicylic acid (2960.89 ± 11.00 µg/g) and 4-hydroxybenzoic acid (1561.42 ± 38.62 µg/g) were the most abundant in the analyzed extracts. The roots of the third cut and the stems were found to be the richest in polyphenolic compounds. These findings suggest that different morphological parts of lucerne could be used as food additives or supplement components due to their nutritional properties.
Comparison of Outcomes of Silicone Tube Intubation with or without Dacryoendoscopy for the Treatment of Congenital Nasolacrimal Duct Obstruction
Authors: Lew Helen , Kim Doah 
Published: April 2023

Abstract
In this retrospective study, we compared and analyzed two groups of patients undergoing silicone tube intubation (STI) for congenital nasolacrimal duct obstruction (CNDO), one with dacryoendoscopy and one without. A total of 87 eyes from 70 patients were included, with 52 eyes from 41 patients in the group without dacryoendoscopy and 35 eyes from 29 patients in the group with dacryoendoscopy. The total success rate of STI was 90.8%, with a higher success rate of 94.3% in patients treated with dacryoendoscopy compared to 88.5% in patients without. In patients under 36 months of age, the success rate was 100% (23 eyes). Among patients with membranous obstruction at Hasner's valve, all were younger than 36 months old and presented with structural obstruction in the lacrimal drainage system (LDS) (p = 0.024). However, in patients without membrane obstruction at Hasner's valve, both secretory obstruction (46.4%) and structural obstruction (53.6%) in the LDS were observed at similar rates, regardless of age. Combined obstructions were also observed in the LDS in CNDO, and the type of obstruction at Hasner's valve varied in every patient.
Identification and validation of novel plant compactness QTL in common wheat
Authors: Zhang Yu , Zhang Weidong , Chen Jiansheng , Wang Yue , Wang Yongzhen , Wang Liang 
Published: April 2023

Abstract
Plant compactness (PC) is one of the most important agronomic traits affecting plant density and further influencing biomass and grain yield potential in a certain area in wheat. The canopy of wheat varieties with high and stable yield should be of appropriate plant architecture aboveground. In the present study, three recombinant inbred line (RIL) populations were generated and utilized to identify and validate plant compactness QTL and SN055525, an erect and compact tillering genotype was used as a common parent. 193 F8 RILs derived from the cross of SN05525/SN22 were genotyped using the high-density Illumina iSelect 90K single nucleotide polymorphism (SNP) assay. A linkage map containing 7180 SNP loci was constructed and six QTL controlling compact tillers were identified on Chromosomes 3B (Qpc.sdau-3B.1, Qpc.sdau-3B.2), 5B (Qpc.sdau-5B), 5D (Qpc.sdau-5D), 2A (Qpc.sdau-2A) and 7A (Qpc.sdau-7A). Qpc.sdau-3B.1, Qpc.sdau-5D and Qpc.sdau-5B explained up to 16.70, 16.89, and 14.56 % of the phenotypic variance, respectively. Kompetitive allele-specific PCR (KASP) markers for the three identified QTL were developed and the effects of these QTL were further validated in two additional RIL populations SN05525/luyuan 502 and SN05525/Xinong 511. Significant compactness effects of Qpc.sdau-3B.1 and Qpc.sdau-5D were detected in validation genetic backgrounds. The closely linked KASP markers could potentially be utilized in marker-assisted selection to modulate plant compactness as well as for further characterization of the gene(s) underlying these loci.
Resource flow characterisation and sustainable value creation analysis for the holistic circularity assessment of wastewater systems
Authors: Renfrew David , Vasilaki Vasileia , Nika Elisa , Harris Eliza , Tsalidis George , Katsou Evina 
Published: April 2023

Abstract
The water sector is at the forefront of the circular economy transition due to the direct reliance industry and society has on clean water supply and adequate wastewater management. The circular use of wastewater has attracted significant attention in recent years, however, there is a lack of universal definitions and measurement tools required to achieve the circular economy’s full potential. The proposed methodology overcomes prominent problems for the circularity assessment of wastewater treatment processes. The resource classification framework developed facilitates robust indicator calculation for comparative assessments. Combining three indicator typologies, namely resource flow, action, and sustainability indicators, enables a normative circularity assessment, that uses value propositions to identify circular actions for the systematic investigation of the impacts to sustainable value creation. The assessment is exhibited by applying it to a case study, comparing conventional and novel photobioreactor wastewater treatment technologies. Resource flow indicator results highlighted improved outflow circularity, renewable energy usage, and economic performance of the photobioreactor system. Action indicators revealed that the photobioreactor technology was successful at achieving the defined value creating goals. Lastly, sustainability indicators enabled the direct quantification of environmental, economic, and social value creation, confirming that stakeholder benefits result from the photobioreactor wastewater treatment technology.
The Stem Cell Division-Related Gene Signature for Risk Stratification and Prognosis of Survival in Lower-Grade
Authors: Jiang Longyang , Zhu Jun , Yang Xuping , Li Junxin , Wang Shurong 
Published: April 2023

Abstract
Background: Cancer stem cell genes are proven to be associated with the prognosis of multiple cancers. Nevertheless, the prognosis and role of stem cell division-related genes in lower-grade glioma (LGG) remains unclear.
Objective: This study constructs a reliable risk model of stem cell division-related genes for predicting the prognosis of LGG patients.
Methods: The mutation data, FPKM data and corresponding clinical information of 511 LGG patients were downloaded from the TCGA database. We carried out LASSO regression analysis and multivariate cox regression analysis to build a risk gene model. The Kaplan-Meier survival analysis was used to evaluate the OS rate of LGG patients. The ROC curve assesses its power across the entire data set.
Results: We acquired a total of 30 candidate stem cell division-related genes. Finally, 11 genes were selected (EV12B,ING2, MLLT3, NCOA3, NOTCH1, PRDM15, SFRP2, SMYD5, THOC2, TIAL1 and WNT7A) to construct risk models. We analyzed the genetic alterations of the selected 11 genes in LGG using the cBioPortal database. Mutations were present in all of the 511 patients. The results showed that all query genes were changed in 101 out of 511 cases(19.77%). The 11-gene marker panel was confirmed as an independent prognostic indicators(P<0.001, HR = 1.061, 95% CI = 1.042-1.079). The Kaplan-Meier survival analysis showed that patients with low risk scores survived longer than those with high risk scores.The AUC was 0.827 suggesting that this 11-gene signature played an important role and accuracy in the efficacy of this diagnosis.
Conclusion: Our study built a prognostic model consisting of 11 stem cell division-related genes for predicting the prognosis of LGG patients. This may be a new biomarker for predicting LGG. These preliminary findings may provide some useful values for clinical prognosis of LGG and future studies.
A case report of successful delayed interval delivery of one fetus in twin pregnancy
Authors: jingzhang  
Published: April 2023

Abstract
This report describes a case of twin pregnancy in which the first fetus was delivered at 18 weeks and 1 day, while the second fetus remained in utero for a further 147 days before vaginal delivery. Multiple pregnancies have a higher incidence of complications, preterm birth, and abortion compared with single pregnancies, and while the second fetus in twin pregnancies is typically delivered soon after the first, continued pregnancy can sometimes result in improved outcomes for the newborn. However, there are no guidelines for the management of delayed delivery in twin pregnancies. This case report describes a successful delayed delivery in our hospital.
In-Bag extraction tissue through the middle part incision of posterior vagina in laparoscopic myomectomy：a large retrospective study
Authors: Zhao Xin , Liu Yansong , Shi Yulin , Niu Jumin 
Published: April 2023

Abstract
Background To describe the outcomes of in-bag extraction tissue through the middle part incision of posterior vagina in laparoscopic myomectomy.Methods This was a retrospective study of patients with laparoscopic myomectomy who underwent the middle part incision of posterior vagina to extraction tissue in bag between January 2016 and December 2022. We collected and analyzed data about patients’ characteristics, main indication for surgery, and intra- and postoperative complications.There were 37 cases of vaginal delivery of pregnant women after operation, and there was no laceration of the incision of the posterior wall of the vagina after delivery.Results A total of 511women underwent transvaginal specimen retrieval after laparoscopic myomectomy (mean largest myoma diameter: 8.44 ± 3.56cm; mean specimen weight: 789.23 ± 276.97g; mean operative time: 129.01 ± 53.13minutes; mean blood loss: 175.99 ± 210.96 mL). Within 30-days, no fever, infection, or vaginal bleeding, and the vaginal incisions healed well after 30 days of outpatient review.There was no incisional hernia, pelvic infection and vaginal adhesions during follow-up 3 months after operation.Conclusions The middle part incision of posterior vagina and in-bag transvaginal extraction can be considered a feasible technique at laparoscopic myomectomy.
Characterization of Modified Refractivity Across the Arid Region of Nigeria
Authors: Imaga George , Israel Emmanuel , Egoigwe Sochima 
Published: April 2023

Abstract
Over time, atmospheric ducts have been studied in a bid to understand and harness for optimal tropospheric propagation of radio waves. The most useful quantity in the study of ducts is the modified refractivity. The gradient of modified refractivity is used in the classification of anomalous propagation conditions. This study characterizes modified refractivity across arid regions of Nigeria, using meteorological data obtained from the European Centre for Medium – Range Weather Forecasts (ECMWF) Re-analysis 5 (ERA-5. It takes a bit - by - bit look at the variables that form radio signal trapping from the very fundamental temperature and relative humidity to the modified refractivity gradient which describes the radio signal trapping characteristics. The study location of relevance is the arid region of Nigeria, and five locations are randomly selected. The analyses of results show a high occurrence of ducts through diurnal and seasonal variations in the arid region. These results are in agreement with the physics of the meteorological parameters in which modified refractivity is dependent upon.
The effect of female age on pregnancy outcomes in patients with pre-implantation testing for aneuploidy (PGT-A): a multicenter retrospective study
Authors: huang bixia , Li Ning , Wang Xiaofei , Xu Bin , Li Yanping , Zhao Jing 
Published: April 2023

Abstract
Objective This study aimed to evaluate the effect of female age on pregnancy outcomes of couples with PGT-A treatment and to find potential correlations or trends.Methods A multicenter retrospective study was conducted among women with pre-implantation testing for aneuploidy (PGT-A) cycles from three reproductive centers in China. They were divided into four groups according to female age (Group A: <30 years old, Group B: 30–34, Group C: 35–39, and group D: ≥40). The primary outcome was the clinical pregnancy rate (CPR) and the live birth rate (LBR). secondary outcomes were the biochemical pregnancy rate (BPR), early miscarriage rate (EMR), and preterm birth rate (PBR).Results A total of 603 PGT-A cycles were included in the present study. There were 161, 256, 147, and 39 cycles in Group A, B, C, D, respectively. The CPR was 53.8% in Group D, which was decreased compared with Group A (60.2%), Group B (56.3%), and Group C (59.2%). The LBRs were 52.8%, 48.4%, 42.9%, and 41.0%, respectively. EMRs were 11.3%,9.7%,24.1%, 23.8%. And PBRs were 4.7%, 7.3%, 9.1%, and 25.0% in Group A, B, C, and D, respectively. The EMR and PBR showed significantly different among groups. Binary Logistic regression analysis indicated maternal age affects the live birth rate (OR 0.937, 95%CI 0.883–0.995), Early miscarriage rate (OR 1.148, 95%CI 1.033–1.275) and Preterm birth rate (OR 1.196, 95%CI 1.017–1.405).Conclusion As pregnancy outcomes tend to decrease with maternal age after euploid embryo transfer. The results indicated that endometrial receptivity, another key factor for embryo implantation, was affected by female age. During the ART treatment for women with advanced maternal age, we should not only pay attention to oocyte/embryos quality, but also emphasize endometrial receptivity.