bluuebunny/crossref_metadata_2025_split huggingface dataset:
The State of the Sublime: Aesthetic Protocols and Global Security
Authors: Austin Jonathan Luke , Leander Anna 
Published: January 2023

Security politics is everywhere, its tendrils entangled with every aspect of life. Nonetheless, this hyper-securitised status quo has not interrupted the flow of everyday life, nor the circulation of people, goods, or ideas. For the privileged of the world, a paradox has emerged: war, terrorism, ecological disaster, pandemics, and many other ‘monstrous’ forms of insecurity are now experienced as mundane and manageable phenomena in spite of the exceptional political measures, and more generalised affective states of fear and anxiety, that they have proliferated. How has this occurred? This article argues that aesthetic processes and politics are fundamental to the maintenance of this paradox. To do so, we draw on Bruno Latour’s concept of ‘transfrayeurs’ (trans-fears) to understand how modes of aesthetic design are deployed to simultaneously locate sublime imaginaries of insecurity in our midst while also allowing us to live with, accept, and forget their presence. More specifically, we suggest that trans-fearing is achieved through ‘aesthetic protocols’ that specify principles for designing material, affective, and discursive forms into our lives in ways that allow for the careful ‘calibration’ of how we (unequally) experience a hierarchised, depoliticised, and militarised ‘state of the sublime’ within global security politics. L’État du sublime : protocoles esthétiques et sécurité mondiale
A prospective comparative evaluation of preoperative stone scoring systems with respect to stone free rate and complications in percutaneous nephrolithotomy
Authors: Haldar Bikram , Sarkar Debansu , Chatterjee Souvik , Pal Dilip Kumar 
Published: January 2023

Background: PCNL outcomes among urologists are different because of the vast heterogeneity in the methods for clinical, academic characterisation and evaluation of surgical outcomes of nephrolithiasis. So assessing the preoperative factors that affect SFR (Stone Free Rate) and complications is critical. Heterogeneity in reporting of PCNL outcomes among different centres has led to the invention of nephrolithotomy scoring systems based on preoperative parameters to better counsel patients contemplating PCNL. The Guy’s stone score, CROES nomogram and the S.T.O.N.E score are seen as predictors of stone-free status (SFS) and complications after PCNL. No universally accepted stone scoring system for predicting SFR and complications after PCNL exists. This is a prospective observational study to compare and analyse the existing stone scoring systems (SSS) and to assess the best parameters to predict PCNL outcomes concerning SFR and complications. Methods: This study is done in a tertiary level institute in eastern India which included 200 patients who underwent PCNL from November 2019 to November 2021. The relevant operative parameters were documented and compared to the preoperative factors with the help of nephrolithotomy scoring systems. Results: The Guy score, CROES nomogram and S.T.O.N.E. score were accurate in predicting the SFR in patients undergoing PCNL. A new IPGMER preoperative stone scoring system based on the most relevant parameters could be used as an alternative to predict SFR and complications in PCNL. Conclusion: The Nephrolithometry scoring systems are simple, straightforward and easily reproducible systems to classify the severity of nephrolithiasis and to stratify the complexity of PCNL.
Ownership Transformations in a Post-Transition Economy: Which Institutions Matter? Evidence from the Polish Banking Sector
Authors: Klepczarek Emilia , Wieczorek Agata 
Published: January 2023

In this article, we investigate what kind of institutions affect bank ownership transformations in a post-transition economy. We use statistical data concerning mergers and acquisitions in the Polish banking sector over the thirty years since the political transformation. Our results indicate the significant role of political and cultural institutional dimensions in stimulating ownership transformation. The importance and current deficits in explaining Polish banking ownership transformations are evaluated through institutional analysis, emphasising the path dependence role and the critical junctures that influence the development of institutions. Identifying which institutions matter the most is crucial for post-reform economies when selecting the most effective policies. Classification codes G21, G32, G34
Understanding Barriers and Facilitators to Online and App Activities for People Living With Dementia and Their Supporters
Authors: Lee Abigail R. , McDermott Orii , Orrell Martin 
Published: January 2023

Background Stigma often surrounds people with dementia when it comes to use of computer technology, although evidence does not always support this. More understanding is needed to investigate attitudes and experience in relation to computer technology use among those living with dementia and their readiness to use it to support self-management. Methods An online self-report questionnaire was completed by adults living with a dementia diagnosis and those living with them. Questions explored how long the participants had been using computer technology; how regularly they used it; the popularity of common communication apps; and whether they were interested in using an app to support their independence. Results 47 participants with dementia and 62 supporters responded to the questionnaire. There were no obvious differences between those with dementia and supporters when it came to regular technology usage and both groups showed positive attitudes to the use of it for independence in dementia. Conclusions There was active use of computer technology among this population. Benefits were shown to include communication, increasing individuals’ understanding of dementia diagnoses, and enabling independent activities for both those with dementia and supporters.
Effects analysis of thermo-mechanical loads on classified damage characteristics with the equivalent cylinder head model
Authors: Yang Wenjun , Kang Xin , Pang Jianchao , Yan Xin , Sui Dongdong , Wang Lei 
Published: January 2023

As a vulnerable part of diesel engine, cylinder head is periodically subjected to the thermo-mechanical coupling loads. While due to the restriction of complex structures and working conditions, it makes the damage mechanism of thermo-mechanical coupling still unclear. In this research, thermo-mechanical responses are predicted successfully by load spectrums and the Sehitoglu theory. Then the effects of working loads on classified damage characteristics are analyzed with the equivalent cylinder head model. The results show that the deviations of temperature and stress are, respectively, within 10°C and 30 MPa, and it verifies the effectiveness of simulated component. Operating speed takes the greatest effect on the thermo-mechanical characteristics, and bolt force and gas pressure are negatively correlated with the responses of stress and strain. Fatigue life and damage are determined by the values of working loads. The effect of temperature load is the most dominant, MechDam and OxidDam increase substantially when operating speed exceeds 3500 r/min. The research will provide a theoretical reference for engineering design and optimization of cylinder head.
Outcome and Cost-Effectiveness Analysis of Long-acting G-CSF as Primary Prophylaxis of Neutropenia Induced by Chemotherapy in Breast Cancer Patients, From a Retrospective Study
Authors: Wang Yaqin , Zhao Chenglong , Ma Peizhi , Jiang Dandan 
Published: January 2023

Purpose This retrospective analysis aimed to evaluate the clinical outcomes and cost-effectiveness of long-acting granulocyte-colony stimulating factor as primary prophylaxis of neutropenia caused by chemotherapy for breast cancer. Methods Patients with breast cancer who received long- or short-acting granulocyte-colony stimulating factor as primary prophylaxis of neutropenia were enrolled in this study, and incidences of neutropenia were compared between two groups. A decision-analytic and a Markov model were used to compare the health benefits and costs of utilizing long- vs short-acting granulocyte-colony stimulating factor as the primary prophylaxis from the perspective of the Chinese health service system. Subsequently, one-way deterministic and probabilistic sensitivity analyses were conducted. The incremental cost-effectiveness ratios were calculated in baseline and sensitivity analyses. Results Patients receiving long-acting granulocyte-colony stimulating factor as the primary prophylaxis of chemotherapy-induced neutropenia experienced a significant lower incidence of this adverse event, compared with the short-acting one for 2 to 7 days. The outcomes of baseline analysis indicated that long-acting granulocyte-colony stimulating factor had a gain of 0.08 quality-adjusted life years and costed $149 more than the short-acting one, yielding an incremental cost-effectiveness ratio of $1792 per quality-adjusted life year. The sensitivity analysis proved the stability of our models and economic efficiency of long-acting granulocyte-colony stimulating factor. Conclusions Patients receiving long-acting granulocyte-colony stimulating factor as primary prophylaxis of neutropenia experienced lower risk of this event compared with those underusing short-acting one. The long-acting granulocyte-colony stimulating factor may be a more cost-effective strategy for primary prophylaxis of neutropenia than short-acting one, considering the Chinese willingness-to-pay threshold of $12158.6 per quality-adjusted life year.
Gerontological social workers’ perspectives about the future at the start of a COVID-19 vaccination program: A photovoice study
Authors: Dias Sofia Fontoura , Araújo Lia , Sousa Liliana 
Published: January 2023

Summary The COVID-19 pandemic is a continuing public health crisis, although it has lessened in its intensity since the start of worldwide vaccination programs. In aged care facilities, gerontological social workers have become frontline professionals facing multiple challenges and demands. One year after the first COVID-19 case in Portugal, during the second major lockdown in the country, and with vaccination starting in these facilities, a photovoice program to identify the experiences of these professionals was developed. This study aimed to understand how gerontological social workers foresee the future of practice and intervention with older adults. A thematic analysis was conducted based on the photographs and associated narratives from 10 participants, all female, aged between 22 and 35 years, who attended a program’s session. Findings Three themes were identified with the thematic analysis: (1) personal and professional growth (with renewed life perspectives and increased resilience), (2) reinvention of intervention (with improved management of emotions, teamwork, and alternative ways of intervening), and (3) hope to use the lessons learned (hope that vaccination will bring conditions to recover the older adults’ well-being and opportunities to use the good lessons learned). Applications These findings are relevant to inform policymakers and governments about practices in aged care facilities and to improve the training of gerontological social workers in acute action management and intervention. We stress alternative ways of intervening that came up in the response to the pandemic such as emotional management, digital technology, communication strategies, self-care, or the families’ involvement.
Sharps and needlestick injuries within the operating room: Risk prone procedures and prevalence meta-analysis
Authors: Bevan Victoria , Blake Paul , Radwan Rami Nigel , Azzopardi Ernest 
Published: January 2023

Background: Sharps and needlestick injuries pose a serious risk to operating theatre personnel with considerable morbidity, mortality and healthcare implications. The cost of prophylaxis and post-exposure treatment is a significant institutional economic burden. Aim: The aim of the review was to identify the prevalence of sharps and needlestick injury within the operating theatre and to establish the most common critical steps. Method: A systematic literature search was conducted. Abstracts of all studies published in English from 2015 onwards exploring sharps and needlestick injury within the operating theatre were reviewed. Primary outcome measure was sharps and needlestick injury prevalence. Secondary outcome measures included operational steps resulting in sharps and needlestick injury and costs of sharps and needlestick injury management. Results: Sixteen studies were identified and included in analysis. Cross-sectional studies reported a pooled prevalence of 41.5% (n = 537; 95% confidence interval = 15.961 to 70.220). Retrospective data analysis reported an annualised prevalence of 5.027% (95% confidence interval = 0.676 to 13.073) on a total pooled sample population of 12,929. Further analysis of operational steps identified a 22% prevalence (n= 3460; 95% confidence interval = 14.2 to 31.3) of sharps and needlestick injury occurring during a procedure involving handing or receiving an instrument. Conclusion: Sharps and needlestick injuries are a significant but preventable risk in the operating theatre. Further research into the development of safety devices to reduce injury during instrument transfer is paramount.
INPP5K controls the dynamic structure and signaling of wild-type and mutated, leukemia-associated IL-7 receptors
Authors: Moës Bastien , Li Hua , Molina-Ortiz Patricia , Radermecker Coraline , Rosu Adeline , Vande Catsyne Charles-Andrew , Sayyed Sufyan Ali , Fontela João , Duque Mafalda , Mostafa Alice , Azzi Abdelhalim , Barata João T. , Merino Ramon , Xu Chenqi , Desmet Christophe J. , Schurmans Stéphane 
Published: January 2023

Abstract
The downstream signaling of the interleukin-7 (IL-7) receptor (IL-7R) plays important physiological and pathological roles, including the differentiation of lymphoid cells and proliferation of acute lymphoblastic leukemia cells. Gain-of-function mutations in the IL-7Rα chain, the specific component of the receptor for IL-7, result in constitutive, IL-7–independent signaling and trigger acute lymphoblastic leukemia. Here, we show that the loss of the phosphoinositide 5-phosphatase INPP5K is associated with increased levels of the INPP5K substrate phosphatidylinositol 4,5-bisphosphate (PtdIns[4,5]P2) and causes an altered dynamic structure of the IL-7 receptor. We discovered that the IL-7Rα chain contains a very conserved positively charged polybasic amino acid sequence in its cytoplasmic juxtamembrane region; this region establish stronger ionic interactions with negatively charged PtdIns(4,5)P2 in the absence of INPP5K, freezing the IL-7Rα chain structure. This dynamic structural alteration causes defects in IL-7R signaling, culminating in decreased expressions of EBF1 and PAX5 transcription factors, in microdomain formation, cytoskeletal reorganization, and bone marrow B-cell differentiation. Similar alterations after the reduced INPP5K expression also affected mutated, constitutively activated IL-7Rα chains that trigger leukemia development, leading to reduced cell proliferation. Altogether, our results indicate that the lipid 5-phosphatase INPP5K hydrolyzes PtdIns(4,5)P2, allowing the requisite conformational changes of the IL-7Rα chain for optimal signaling.
Protocol for Evaluating In Vivo the Activation of the P2RX7 Immunomodulator
Authors: Janho dit Hreich Serena , Juhel Thierry , Hofman Paul , Vouret-Craviari Valérie 
Published: January 2023

Abstract
Background
P2RX7 is a purinergic receptor with pleiotropic activities that is activated by high levels of extracellular ATP that are found in inflamed tissues. P2RX7 has immunomodulatory and anti-tumor proprieties and is therefore a therapeutic target for various diseases. Several compounds are developed to either inhibit or enhance its activation. However, studying their effect on P2RX7’s activities is limited to in vitro and ex vivo studies that require the use of unphysiological media that could affect its activation. Up to now, the only way to assess the activity of P2RX7 modulators on the receptor in vivo was in an indirect manner.

Results
We successfully developed a protocol allowing the detection of P2RX7 activation in vivo in lungs of mice, by taking advantage of its unique macropore formation ability. The protocol is based on intranasal delivery of TO-PRO™-3, a non-permeant DNA intercalating dye, and fluorescence measurement by flow cytometry. We show that ATP enhances TO-PRO™-3 fluorescence mainly in lung immune cells of mice in a P2RX7-dependant manner.

Conclusions
The described approach has allowed the successful analysis of P2RX7 activity directly in the lungs of WT and transgenic C57BL6 mice. The provided detailed guidelines and recommendations will support the use of this protocol to study the potency of pharmacologic or biologic compounds targeting P2RX7.
Single-cell multi-omics integration for unpaired data by a siamese network with graph-based contrastive loss
Authors: Liu Chaozhong , Wang Linhua , Liu Zhandong 
Published: January 2023

Abstract
Background
Single-cell omics technology is rapidly developing to measure the epigenome, genome, and transcriptome across a range of cell types. However, it is still challenging to integrate omics data from different modalities. Here, we propose a variation of the Siamese neural network framework called MinNet, which is trained to integrate multi-omics data on the single-cell resolution by using graph-based contrastive loss.

Results
By training the model and testing it on several benchmark datasets, we showed its accuracy and generalizability in integrating scRNA-seq with scATAC-seq, and scRNA-seq with epitope data. Further evaluation demonstrated our model's unique ability to remove the batch effect, a common problem in actual practice. To show how the integration impacts downstream analysis, we established model-based smoothing and cis-regulatory element-inferring method and validated it with external pcHi-C evidence. Finally, we applied the framework to a COVID-19 dataset to bolster the original work with integration-based analysis, showing its necessity in single-cell multi-omics research.

Conclusions
MinNet is a novel deep-learning framework for single-cell multi-omics sequencing data integration. It ranked top among other methods in benchmarking and is especially suitable for integrating datasets with batch and biological variances. With the single-cell resolution integration results, analysis of the interplay between genome and transcriptome can be done to help researchers understand their data and question.
PLAGL1 is associated with prognosis and cell proliferation in pancreatic adenocarcinoma
Authors: Liang Xing , Fu Zhiping , Tang Liang , Zheng Minghui , Chen Danlei , Liu Anan , Shi Ligang , Yang Linhua , Shao Chenghao , Dong Xiaoqiang 
Published: January 2023

AbstractBackgroundEmerging evidence has shown the crucial roles ofpleomorphic adenoma gene(PLAG) family genes in multiple cancers. However, their functions and mechanisms in pancreatic adenocarcinoma (PAAD) remain poorly understood.MethodsWe analyzed the expression levels ofPLAGfamily genes in both The Cancer Genome Atlas (TCGA) database and a Gene Expression Omnibus (GEO) database, and confirmed the results in our three independent cohorts of 382 PAAD tissues and 362 adjacent nontumor pancreatic tissues. Integrated analyses were carried out to explore the function, mechanism and prognostic value of the selectedPLAGfamily gene in PAAD patients.ResultsBy analyzing the TCGA and GEO databases,PLAGL1was identified to be downregulated in PAAD tissues, and its decreasing levels of both mRNA and protein were verified in our three independent PAAD cohorts. PLAGL1 expression was inversely correlated with clinicopathological factors including the Ki67+cell rate and pathologic stage. Further GSEA of the TCGA-PAAD cohort demonstrated that multiple signaling pathways implicated in cell proliferation were enriched in the lowerPLAGL1expressing PAAD group. Moreover, we demonstrated thatPLAGL1expression was obviously negatively associated with patients’ overall survival outcome in both the TCGA-PAAD cohort and our verification cohorts. Additionally, through MTS and BrdU assays, we further demonstrated in vitro that PLAGL1 had the impact of preventing the proliferation of pancreatic cancer cells.ConclusionsOur present study suggested that downregulatedPLAGL1might act as a biomarker in predicts poor prognosis and one of important factors in increasing cell proliferation in PAAD. This study provides us with a novel prognostic marker and therapeutic strategy for PAAD, which deserves further study.
The prevalence of eHealth literacy and its relationship with perceived health status and psychological distress during Covid-19: a cross-sectional study of older adults in Blekinge, Sweden
Authors: Ghazi Sarah Nauman , Berner Jessica , Anderberg Peter , Sanmartin Berglund Johan 
Published: January 2023

AbstractBackground and aimseHealth literacy is important as it influences health-promoting behaviors and health. The ability to use eHealth resources is essential to maintaining health, especially during COVID-19 when both physical and psychological health were affected. This study aimed to assess the prevalence of eHealth literacy and its association with psychological distress and perceived health status among older adults in Blekinge, Sweden. Furthermore, this study aimed to assess if perceived health status influences the association between eHealth literacy and psychological distress.MethodsThis cross-sectional study (October 2021-December 2021) included 678 older adults’ as participants of the Swedish National Study on Aging and Care, Blekinge (SNAC-B). These participants were sent questionnaires about their use of Information and Communications Technology (ICT) during the COVID-19 pandemic. In this study, we conducted the statistical analysis using the Kruskal-Wallis one-way analysis of variance, Kendall’s tau-b rank correlation, and multiple linear regression.ResultsWe found that 68.4% of the participants had moderate to high levels of eHealth literacy in the population. Being female, age$$< 75$$<75years, and having a higher education are associated with high eHealth literacy ($$p< 0.05$$p<0.05). eHealth literacy is significantly correlated ($$\tau$$τ=0.12,p-value=0.002) and associated with perceived health status ($$\beta$$β=0.39,p-value=0.008). It is also significantly correlated ($$\tau$$τ=-0.12,p-value=0.001) and associated with psychological distress ($$\beta$$β=-0.14,p-value=0.002). The interaction of eHealth literacy and good perceived health status reduced psychological distress ($$\beta$$β=-0.30,p-value=0.002).ConclusionsIn our cross-sectional study, we found that the point prevalence of eHealth literacy among older adults living in Blekinge, Sweden is moderate to high, which is a positive finding. However, there are still differences among older adults based on factors such as being female, younger than 75 years, highly educated, in good health, and without psychological distress. The results indicated that psychological distress could be mitigated during the pandemic by increasing eHealth literacy and maintaining good health status.