bluuebunny/crossref_metadata_2025_split huggingface dataset:
The behavior of Broad-tailed hummingbirds is altered by cycles of human activity in a forested area converted into agricultural land
Authors: Mendiola-Islas Verónica , Lara Carlos , Corcuera Pablo , Valverde Pedro Luis 
Published: February 2023

BackgroundBy changing the circumstances in which animals make their behavioral decisions, weekly cycles of human activity might cause changes in wildlife behavior. For example, when there is more human activity in a location, animals may become more vigilant, which can decrease the time they spend foraging, or roam farther from home, leading to increased home range size. Overall, there has been little exploration of how animal species living in locations that have undergone land use change are affected by the temporal dynamics of human activity levels. In this study, we aimed to analyze the effect of the weekend on agricultural activities and hummingbird territorial activity. We examined differences between weekdays and weekends in factors previously shown to follow weekly cyclical patterns, such as pedestrian presence, traffic, and the presence of domestic animals. We hypothesized that territorial hummingbirds would respond to these weekly cycles of human activity by altering their behavior.MethodsWe studied Broad-tailed hummingbird territories in forested areas that had been transformed to agriculture lands in central Mexico. We evaluated whether territorial individuals changed their behaviors (i.e., chases of intruders, foraging within their territory, number of intruders allowed to forage in the territory) in response to variation between weekdays and weekends in the number of pedestrians, cyclists, dogs, farm animals and vehicles.ResultsWe found that the level of agriculture-related human activities showed a weekly cycle at our study site. On weekdays there was higher traffic of pedestrians, cyclists, dogs, farm animals and vehicles, compared to the weekends. Hummingbirds responded to these weekday-weekends differences by changing their territorial behavior. Compared to weekends, on weekdays hummingbirds showed a decrease in defense (number of chases) as well as the use of their territory (number of flowers visited), which allowed increased access to intruders (number of visited flowers by intruders).ConclusionsOur findings suggest that variation in agriculture-related human activities between weekdays and weekends can alter the territorial behavior of hummingbirds. Behavioral shifts seem to be related to these human activity cycles, leading hummingbirds to reduce chases and feeding during weekdays when human activity is highest, but increasing both behaviors during times of minimal disturbance.
Tough Porous Silk Nanofiber‐Derived Cryogels with Osteogenic and Angiogenic Capacity for Bone Repair
Authors: Hou Jianwen , Ding Zhaozhao , Zheng Xin , Shen Yixin , Lu Qiang , Kaplan David L 
Published: February 2023

AbstractTough porous cryogels with angiogenesis and osteogenesis features remain a design challenge for utility in bone regeneration. Here, building off of the recent efforts to generate tough silk nanofiber‐derived cryogels with osteogenic activity, deferoxamine (DFO) is loaded in silk nanofiber‐derived cryogels to introduce angiogenic capacity. Both the mechanical cues (stiffness) and the sustained release of DFO from the gels are controlled by tuning the concentration of silk nanofibers in the system, achieving a modulus above 400 kPa and slow release of the DFO over 60 days. The modulus of the cryogels and the released DFO induce osteogenic and angiogenic activity, which facilitates bone regeneration in vivo in femur defects in rat, resulting in faster regeneration of vascularized bone tissue. The tunable physical and chemical cues derived from these nanofibrous‐microporous structures support the potential for silk cryogels in bone tissue regeneration.
Dually Crosslinked Copper‐Poly(tannic acid) Nanoparticles with Microenvironment‐Responsiveness for Infected Wound Treatment
Authors: Li Dongying , Li Jiarun , Wang Siwei , Wang Qinmei , Teng Wei 
Published: February 2023

AbstractReducing the burden of death due to wound infection is an urgent global public health priority. Metal‐phenolic networks (MPNs) have received widespread attention in antimicrobial infections due to their facile synthesis process, excellent biocompatibility, and antimicrobial properties brought about by polyphenols and metal ions. However, typical therapeutic MPNs show rapid release of metal ions due to their poor solution stability, impeding long‐acting efficacy in multiple wound healing stages. To address these issues, copper‐poly (tannic acid) nanoparticles (Cu‐PTA NPs): robust (dually crosslinked), microenvironment‐responsive, antibacterial, antioxidative, and anti‐inflammatory are prepared, which hierarchically modulate the infected wound healing process. Covalently polymerized via phenol‐formaldehyde condensation and crosslinked with bioactive Cu2+, reactive polyphenols are preserved, and Cu2+ is efficiently entrapped in the PTA scaffold. The proposed strategy relieves the systemic toxicity, and only high reactive oxygen species (ROS)level as stimuli can “turn on” the catalytic activity of Cu2+ to implement antibacterial therapy specifically in an infected wound. Systematic tissue regeneration assessment on the infected full‐thickness skin wounds of rats demonstrates enhanced wound healing rate. Cu‐PTA NPs enables the direct application in infected wound and exertion of long‐acting healing efficacy. This synergetic therapy strategy will pave the way for more complicated infections and inflammatory diseases.
Zinc‐Contained Alloy as a Robustly Adhered Interfacial Lattice Locking Layer for Planar and Stable Zinc Electrodeposition
Authors: Ji Jie , Zhu Zhenglu , Du Haoran , Qi Xiaoqun , Yao Jia , Wan Houzhao , Wang Hao , Qie Long , Huang Yunhui 
Published: February 2023

AbstractStable zinc (Zn)/electrolyte interface is critical for developing rechargeable aqueous Zn‐metal batteries with long‐term stability, which requires the dense and stable Zn electrodeposition. Herein, an interfacial lattice locking (ILL) layer is constructed via the electro‐codeposition of Zn and Cu onto the Zn electrodes. The ILL layer shows a low lattice misfit (δ = 0.036) with Zn(002) plane and selectively locks the lattice orientation of Zn deposits, enabling the epitaxial growth of Zn deposits layer by layer. Benefiting from the unique orientation‐guiding and robustly adhered properties, the ILL layer enables the symmetric Zn||Zn cells to achieve an ultralong life span of >6000 h at 1 mA cm−2 and 1 mAh cm−2, a low overpotential (65 mV) at 10 mAh cm−2, and a stable Zn plating/stripping for >90 h at an ultrahigh Zn depth of discharge (≈85%). Even with a limited Zn supply and a high current density (8.58 mA cm−2), the ILL@Zn||Ni‐doped MnO2 cells can still survive for >2300 cycles.
Metal‐Redox Bicatalysis Batteries for Energy Storage and Chemical Production
Authors: Yan Shichen , Feng Yangyang , Lin Jing , Wang Yaobing 
Published: February 2023

AbstractNew types of electrochemical energy conversion and storage devices based on redox electrocatalytic reactions possess great potential in renewable energy to maximize energy utilization and balance environmental issues. The typical device is the metal‐redox bicatalysis battery, where the cathode is redox bifunctional catalyst (named as redox bicatalyst) with gas, solid, liquid as active reactants while anode is metal, driven by cathodic redox electrocatalytic reactions during charge/discharge processes, which promotes the energy storage and chemical production. In this system, the metal anode, redox‐bicatalyst cathode, electrolytes, and the redox electrochemical reactions can be modified and adjusted to achieve the optimal energy conversion and utilization. Therefore, the deep understanding of the electrochemical system is conducive to designing new devices to meet the demand among various applications, including energy storage and conversion. In this review, the authors clarify the fundamentals and design principles of the rechargeable/reversible metal‐redox bicatalysis batteries and how each part affects the devices in energy conversion and chemical production. The authors summarize the electrocatalytic reduction/oxidation reactions, the reported systems relied on redox reactions, and the corresponding redox bicatalysts. Finally, a perspective of the key challenges and the possible new types of metal‐redox bicatalysis batteries for efficient energy utilization and chemical production are given.
Antisolvent‐Assisted In Situ Cation Exchange of Perovskite Quantum Dots for Efficient Solar Cells
Authors: Jia Donglin , Chen Jingxuan , Zhuang Rongshan , Hua Yong , Zhang Xiaoliang 
Published: February 2023

AbstractCesium‐formamidinium lead iodide perovskite quantum dots (FAxCs1−xPbI3 PQDs) show high potential for next‐generation photovoltaics due to their outstanding optoelectronic properties. However, achieving composition‐tunable hybrid PQDs with desirable charge transport remains a significant challenge. Herein, by leveraging an antisolvent‐assisted in situ cation exchange of PQDs, homogeneous FAxCs1−xPbI3 PQDs with controllable stoichiometries and surface ligand chemistry are realized. Meanwhile, the crystallographic stability of PQDs is substantially improved by substituting the cations of the PQDs mediated by surface vacancies. Consequently, PQD solar cell delivers an efficiency of 17.29%, the highest value among the homostructured PQD solar cells. The high photovoltaic performance is attributed to the broadened light harvesting spectra, flattened energy landscape, and rationalized energy levels of highly oriented PQD solids, leading to efficient charge carrier extraction. This work provides a feasible approach for the stoichiometry regulation of PQDs to finely tailor the optoelectronic properties and tolerance factors of PQDs toward high‐performing photovoltaics.
Combined Chemoradionuclide Therapy Using Poly(ε‐caprolactone‐b‐ethylene oxide) Micelles as the Delivery Vehicle
Authors: Liu Huanhuan , Nadar Robin A. , Fauzia Retna Putri , Laan Adrianus C. , Doeswijk Britt , Wang Runze , van de Meer Astrid , van Cooten Quenteijn , Carroll Elizabeth C. M. , Eelkema Rienk , Denkova Antonia G. 
Published: February 2023

AbstractCombination of therapies is a common strategy in cancer treatment. Such combined therapies only have merit provided that there is superior therapeutic outcome with fewer side effects, compared to single therapies. Here, this work explores the possibility to combine chemotherapy with radionuclide therapy using polymeric micelles as a delivery vehicle. For this purpose, this work prepares poly(ε‐caprolactone‐b‐ethylene oxide) (PCL‐PEO) micelles and load them simultaneously with paclitaxel (PTX) and 177Lu(III). This work chooses a 3D tumor spheroid composed of glioblastoma cells (U87) to evaluate the combined treatment. The diffusion of the micelles in the spheroid is investigated by confocal laser scanning microscopy (CLSM) and light‐sheet fluorescence microscopy (LSFM). The results show that the micelles are able to penetrate deep into the spheroid within 24 h of incubation and mainly accumulated around or in the lysosomes once in the cell. Subsequently, this work evaluates the cell killing efficiency of the single treatments (PTX or 177Lu(III)) versus combined treatment (PTX + 177Lu(III)) by measuring the growth of the spheroids as well as by performing a cell‐viability assay. The results indicate that the combined therapy achieves a superior therapeutic outcome with better cell growth inhibition and cell killing efficiency compared to the single treatments.
Recent Advances in Modified Brain‐Targeting Drug Delivery Systems for Erythropoietin
Authors: Wang Xia , Yao Siqi , Xiao Jing , He Li , Yang Qiankui , Ming Li , He Yue , Zhang Yuping , Wu Zhifeng 
Published: February 2023

AbstractErythropoietin (EPO) is an excellent neuroprotective molecule that decreases the extent of injury caused by various pathologies of the brain, such as Alzheimer's disease, Parkinson's disease, and stroke. However, due to the low permeability of the blood‒brain barrier (BBB), a high dose or even an overdose of EPO injections is often administered to achieve a sufficient EPO concentration in the brain. This often leads to many serious adverse reactions. Several studies have presented promising strategies for overcoming the BBB to deliver EPO. These methods include the formation of EPO modified by receptor‐mediated transcytosis targeting fusion proteins, cell‐penetrating peptides, and nanomaterials. In this review, the clinical progress of modified brain‐targeting drug delivery systems of EPO is summarized to provide a scientific basis and new information on the application of EPO in treating diseases of the central nervous system. Here, the production, pharmacological effects, and mechanism of action of the modified EPO, as well as the limiting factors and countermeasures are discussed.
Cutting balloon to optimize predilation for stent implantation: The COPS randomized trial
Authors: Mangieri Antonio , Nerla Roberto , Castriota Fausto , Reimers Bernhard , Regazzoli Damiano , Leone Pier P. , Gasparini Gabriele L. , Khokhar Arif A. , Laricchia Alessandra , Giannini Francesco , Casale Fulvio , Bezzeccheri Andrea , Briguori Carlo , Colombo Antonio 
Published: February 2023

AbstractObjectivesThe objective of this study is to investigate the use of cutting balloon (CB) inflated at high pressure compared with noncompliant balloon (NCB) for the treatment of calcified coronary lesions.BackgroundNo data are available regarding the safety and efficacy of CB inflated at high pressure in coronary artery calcifications.MethodsPatients with calcified lesions (more than 100° of calcium demonstrated at baseline intravascular ultrasound) were randomized. Primary endpoint of the study was the final minimal stent area (MSA) and stent symmetry in the calcific segment. Secondary endpoints included rate of device failure and the 1‐year rate of target lesion revascularization, target vessel revascularization, and major adverse cardiovascular events.ResultsFrom September 2019 to June 2021, a total of 100 patients were included and randomized; 13 patients were excluded for major protocol deviations. Lesions were complex (type B2/C n = 61 [71.2%]) with a mean arch of calcium of 266 ± 84°, a calcium length of 12 ± 6.6 mm. CB was inflated at comparable atmospheres when compared with NCB (18.3 ± 5 vs. 19 ± 4.5, p = 0.46). In the per‐protocol population, the final MSA at the level of the calcium site was significantly higher in the CB group (8.1 ± 2 vs. 7.3 ± 2.1, p = 0.035) with a higher eccentricity index achieved in the CB group (0.84 ± 0.07 vs. 0.8 ± 0.08, p = 0.013). Three device failure occurred in the CB group. One‐year follow‐up outcomes were comparable.ConclusionsTreatment of calcified lesions with high‐pressure CB has a good safety profile and is associated with a larger MSA and higher eccentricity of the stent at the level of the calcium site compared with NCB.
A new echocardiographic index to select patients for PFO suture‐mediated percutaneous closure
Authors: Gaspardone Achille , Sgueglia Gregory A. , Gaspardone Carlo , De Santis Antonella , D'Ascoli Emanuela , Piccioni Fabiana , Iamele Maria , Giannico Maria Benedetta , Tarsia Carmela , Versaci Francesco 
Published: February 2023

AbstractObjectivesTo identify a simple echocardiographic predictor of procedural success to select patient for percutaneous suture‐mediated patent fossa ovalis (PFO) closure.BackgroundPercutaneous suture‐mediated PFO closure has been shown as a safe and advantageous alternative to device‐based PFO closure, yet its overall success is slightly lower in unselected patients.MethodsPreprocedural transesophageal echocardiogram (TEE) of 302 patients (113 men, 45 ± 12 years) who underwent percutaneous suture‐mediated PFO closure were reviewed.ResultsAt echocardiographic follow‐up (3–6 months), residual right‐to‐left shunt (RLS) ≥2 was found in 60 (19.9%) patients. At multivariable analysis, only two anatomical variables measured at preprocedural TEE were found as independent predictors of residual RLS ≥ 2 at follow‐up: PFO maximum width (odds ratio [OR] 1.89, 95% confidence interval [CI] 1.16–3.40, p = 0.02) and PFO minimal septa overlapping (OR 0.58, 95% CI 0.35–0.88, p = 0.02). An index based on the ratio of PFO maximum width to PFO minimum septal overlapping (W/SO) proved to be the most powerful predictor of RLS ≥ 2 at follow‐up (OR 48.1, 95% CI 9.3–352.2, p < 0.01). The ROC curve for the W/SO ratio was found to have an AUC of 0.84 (95% CI 0.75–0.93) and a cut‐off value of 0.61 yielding a sensitivity of 80% and specificity of 78% with a negative predictive value of 94%. A decision tree methodology's AUC was 0.75 (95% CI 0.67–0.83).ConclusionsThe results of this study indicate that the ratio between the maximum amplitude of the PFO and the minimum overlap of the septa is the best predictive index of a favorable result by using one stitch only.
Association between insomnia and the incidence of myocardial infarction: A systematic review and meta‐analysis
Authors: Dean Yomna E. , Shebl Mohamed A. , Rouzan Samah S. , Bamousa Bdoor Ahmed A , Talat Nesreen Elsayed , Ansari Sana Afreen , Tanas Yousef , Aslam Muaaz , Gebril Sara , Sbitli Taher , Eweis Ramy , Shahid Rameen , Salem Amr , Abdelaziz Heba Ahmed , Shah Jaffer , Hasan Walaa , Hakim Diaa , Aiash Hani 
Published: February 2023

AbstractBackgroundInsomnia has been closely associated with cardiovascular disease (CVD) including myocardial infarction (MI). Our study aims to assess the eligibility of insomnia as a potential risk factor for MI.MethodsPubMed, Scopus, and Web of Science were searched using terms; such as “Insomnia” and “MI.” Only observational controlled studies with data on the incidence of MI among insomniacs were included. Revman software version 5.4 was used for the analysis.ResultsOur pooled analysis showed a significant association between insomnia and the incidence of MI compared with noninsomniacs (relative risk [RR] = 1.69, 95% confidence interval [CI] = 1.41–2.02, p < .00001). Per sleep duration, we detected the highest association between ≤5 h of sleep, and MI incidence compared to 7−8 h of sleep (RR = 1.56, 95% CI = 1.41–1.73). Disorders of initiating and maintaining sleep were associated with increased MI incidence (RR = 1.13, 95% CI = 1.04–1.23, p = .003). However, subgroup analysis of nonrestorative sleep and daytime dysfunction showed an insignificant association with MI among both groups (RR = 1.06, 95% CI = 0.91–1.23, p = .46). Analysis of age, follow‐up duration, sex, and comorbidities showed a significant association in insomniacs.ConclusionInsomnia and ≤5 h of sleep are highly associated with increased incidence of MI; an association comparable to that of other MI risk factors and as such, it should be considered as a risk factor for MI and to be incorporated into MI prevention guidelines.
Mitochondrial DNA Copy Number Is a Potential Biomarker for Treatment Choice Between Metformin and Acarbose
Authors: Wang Jing , Liang Hua , Wang You , Zheng Xueying , Chen Fei , Shao Jian , Geng Zhaoxu , Zheng Li , Yang Wenying , Weng Jianping , Xu Tao , Zhou Kaixin 
Published: February 2023

Metformin is the first‐line drug for type 2 diabetes (T2D) while acarbose is suggested as a viable alternative in Chinese patients with newly diagnosed T2D. However, few biomarkers have been established to guide the choice between these two agents. Mitochondrial DNA (mtDNA) copy number (mtDNA‐CN) is a biomarker of mitochondrial function, which is associated with various metabolic outcomes. Using data from the trial of Metformin and Acarbose in Chinese as the Initial Hypoglycaemic Treatment (MARCH) (metformin n = 214; acarbose n = 198), we examined whether mtDNA‐CN was associated with response to the drugs in terms of glycemic response and β‐cell function protection response. The glycemic response is defined as the maximum glucose reduction of glycated hemoglobin A1c, fasting plasma glucose, or postprandial blood glucose during 48 weeks. β‐cell function protection response is defined as the maximum increment of insulinogenic index (IGI) or disposition index (DI). For all three glycemic responses, mtDNA‐CN was not significantly associated with either metformin or acarbose. Importantly, for β‐cell function protection response, we found the increased mtDNA‐CN was significantly associated with more IGI increment (beta: 0.84; 95% confidence interval (CI), 0.02 to 1.66) in the metformin group, but less IGI increment (beta: −1.38; 95% CI, −2.52 to −0.23) in the acarbose group. A significant interaction (P = 0.008) between mtDNA‐CN and the treatment group was observed. Consistent results were also obtained when DI increment was used as a measure of β‐cell function response. This study demonstrated the potential application of mtDNA‐CN in guiding the treatment choice between metformin and acarbose based on β‐cell protection.
Numerical study on calculation model of airflow temperature and humidity prediction in humid airway
Authors: Wang Yongjun , Zhang Hemeng , Zheng Qian , Dong Wei , Zhao Ruoji , Zhang Xun , Zhang Xiaoming , Sugai Yuichi , Sasaki Kyuro 
Published: February 2023

AbstractIn deep coal mining, the high temperature and humidity environment are one of the main disasters threatening workers and equipment. To predict the temperature and humidity of airflow in the airway accurately, this study establishes a numerical calculation model of the surrounding rock temperature, airflow temperature, and humidity under the conditions of considering the moisture evaporation and heat absorption of the airway wall, the condensation and heat release of supersaturated water vapor in the airflow, and the influence of air compression or expansion. Combined with the two‐dimensional (2D) heat conduction model (considering the influence of the axial surrounding rock heat conduction of the airway), the axial strip partial moisture calculation model of the airway is proposed, and then the uniform moist wall model and the axial strip partial moist wall model are established. The influence of different parameters on the temperature and humidity of airflow is discussed by analyzing the results of numerical simulation of the uniform wet surface model (UWSM) and partly wet surface model (PWSM) of the airway wall. The results show that the surrounding rock temperature, especially the temperature distribution of the airway wall, calculated by using the 2D heat conduction model under the local humid airway conditions, is more realistic. The increment of airflow temperature decreases with the increase of wet area ratio, airflow temperature at the entrance and airway radius, and increases with relative humidity at the entrance. The calculation accuracy of temperature and humidity prediction for large ventilation networks can be further improved by using the equivalent humidity of the UWSM to replace the correction coefficient of the wet area ratio of the PWSM.