bluuebunny/crossref_metadata_2025_split huggingface dataset:
Timeliness of Breast Diagnostic Imaging and Biopsy in Practice: 15 Years of Collecting, Comparing, and Defining Quality Breast Cancer Care
Authors: Donovan Cory Amanda , Kaufman Cary S. , Thomas Kari A. , Polat Ayfer Kamali , Thomas Marguerite , Mack Bonnie , Gilbert Ariel , Sarantou Terry 
Published: August 2023

Abstract
Background
The literature lacks well-established benchmarks for expected time between screening mammogram to diagnostic imaging and then to core needle breast biopsy.

Methods
Timeliness of diagnostic imaging workup was evaluated using aggregate data from 2005 to 2019 submitted to The National Quality Measures for Breast Centers (NQMBC).

Results
A total of 419 breast centers submitted data for 1,805,515 patients on the time from screening mammogram to diagnostic imaging. The overall time was 7 days with 75th, 25th, and 10th percentile values of 5, 10, and 13.5 days, respectively. The average time in business days decreased from 9.1 to 7.1 days (p < 0.001) over the study period with the greatest gains in poorest-performing quartiles. Screening centers and centers in the Midwest had significantly shorter time to diagnostic imaging. Time from diagnostic imaging to core needle biopsy was submitted by 406 facilities representing 386,077 patients. The average time was 6 business days, with 75th, 25th, and 10th percentiles of 4, 9, and 13.7 days, respectively. Time to biopsy improved from a mean of 9.0 to 6.3 days (p < 0.001) with the most improvement in the poorest-performing quartiles. Screening centers, centers in the Midwest, and centers in metropolitan areas had significantly shorter time to biopsy.

Conclusions
In a robust dataset, the time from screening mammogram to diagnostic imaging and from diagnostic imaging to biopsy decreased from 2005 to 2019. On average, patients could expect to have diagnostic imaging and biopsies within 1 week of abnormal results. Monitoring and comparing performance with reported data may improve quality in breast care.
Natural Language Processing for Enterprise Applications
Authors: A. Bharathi 
Published: August 2023

Researchers are concentrating on more efficient communication technologies that can emulate human interactions and comprehend natural languages and human emotions as a result of people's growing reliance on computer-assisted systems. Unstructured data, which is deemed useless, has increased due to the issue of information overload in every industry, including business, healthcare, education, etc. In this context, natural language processing (NLP) is one of the efficient technologies that may be used with more sophisticated technologies, such as machine learning, artificial intelligence, and deep learning, to enhance the interpretation and processing of natural language. In addition to improving human-computer interaction, this can also enable massive amounts of useless and unstructured data to be analyzed and formatted in numerous industrial applications. This will produce significant results that can improve decision-making and hence increase operational effectiveness. This chapter introduces the idea of NLP, its background, and its current state while also going through examples of its use in various industrial fields.
Keywords: Natural Language Processing, Artificial Intelligence, Machine Learning.
Who Bears Responsibility for the Post-Acute Older Adult: Patient, Family or State?
Authors: Dowling Teresa , Kennedy Sara , Foran Sinéad 
Published: August 2023

Aim: This study explores the perceptions of hospital discharge coordinators on the issues raised for the post-acute older adult and their family, using the lens of assisted decision-making and advance directives. Background: New legislation has been developed in Ireland to support assisted decision-making and advance directives that is largely consistent with other countries around the world. The Assisted Decision-Making Act of 2015 was fully commeced in April 2023, following lengthy debate. However, there is a lot of professional uncertainty regarding how to support and integrate Advance Healthcare Directives and assisted decision-making into the care of adults and into the role of nurses working in the community. Methods: Utilising a qualitative approach, this study conducted a series of five focus groups, with 23 participants, across the South-East of Ireland. Thematic analysis was used to interpret results. The 32-item consolidated criteria for reporting qualitative research checklist was utilised. Findings: The central finding in this study concerned the locus of control, as well as findings on burden of care and the role of the nurse. A stark incongruence of beliefs among patient, family and State was identified. Conclusion: Nurses must learn to circumnavigate the complex terrain involved in supporting the older adult’s advance decision-making and advance healthcare directives.
Overview of Urinary Incontinence
Authors: Palmer Sarah Jane 
Published: August 2023

Urinary incontinence is a common condition, which affects approximately 300 million people globally. In the UK alone, over 7 million people are affected by this condition. There are various physiological factors that contribute to incontinence, such as a weak bladder, weak pelvic floor muscles, overactive bladder muscles, merve damage from muscle sclerosis, diabetes—to name a few. In this article, the author discusses how urinary incontinence can be managed in men and women, alongside mental health considerations.
Living well: exploring experiences of carers of people with motor neurone disease attending an early-access support group
Authors: Derbyshire Julie , Atkinson Joanne , Dunn Yvonne , Lowe Julie-Anne 
Published: August 2023

Background/Aims Motor neurone disease is associated with rapid disease progression and disability, and receiving a diagnosis can cause shock and fear in the patient and their carers. Prompt access to services and psychological support are important to improving quality of life in individuals with motor neurone disease and their carers. The early-access Living Well support group, led by an occupational therapist and a registered nurse, was developed to support people with motor neurone disease and their carers. The objective of this study was to explore the carers’ lived experiences of being part of this support group. Methods Qualitative semi-structured interviews were conducted with eight carers who attended the Living Well group, using a phenomenological research design. These carers had attended a minimum of two sessions with a relative with motor neurone disease. Thematic analysis was used to examine the data. Results Five key themes were generated from the study: diagnosis and fear of hospice; being human; connection with others; escapism; and access to expertise. These themes emphasised the importance of personalisation of support groups that meet the specific needs of those living with motor neurone disease and their carers. Conclusions The findings of this study have implications for palliative care services and occupational therapists who work to improve the quality of life for people living with motor neurone disease and their carers. A more holistic approach towards palliative care, including the involvement of carers in support groups similar to Living Well, is strongly recommended.
Single-step ultra-purified alginate gel implantation in patients with knee chondral defects
Authors: Onodera Tomohiro , Momma Daisuke , Matsuoka Masatake , Kondo Eiji , Suzuki Koji , Inoue Masayuki , Higano Masaki , Iwasaki Norimasa 
Published: August 2023

AimsImplantation of ultra-purified alginate (UPAL) gel is safe and effective in animal osteochondral defect models. This study aimed to examine the applicability of UPAL gel implantation to acellular therapy in humans with cartilage injury.MethodsA total of 12 patients (12 knees) with symptomatic, post-traumatic, full-thickness cartilage lesions (1.0 to 4.0 cm2) were included in this study. UPAL gel was implanted into chondral defects after performing bone marrow stimulation technique, and assessed for up to three years postoperatively. The primary outcomes were the feasibility and safety of the procedure. The secondary outcomes were self-assessed clinical scores, arthroscopic scores, tissue biopsies, and MRI-based estimations.ResultsNo obvious adverse events related to UPAL gel implantation were observed. Self-assessed clinical scores, including pain, symptoms, activities of daily living, sports activity, and quality of life, were improved significantly at three years after surgery. Defect filling was confirmed using second-look arthroscopy at 72 weeks. Significantly improved MRI scores were observed from 12 to 144 weeks postoperatively. Histological examination of biopsy specimens obtained at 72 weeks after implantation revealed an extracellular matrix rich in glycosaminoglycan and type II collagen in the reparative tissue. Histological assessment yielded a mean overall International Cartilage Regeneration & Joint Preservation Society II score of 69.1 points (SD 10.4; 50 to 80).ConclusionThis study provides evidence supporting the safety of acellular UPAL gel implantation in facilitating cartilage repair. Despite being a single-arm study, it demonstrated the efficacy of UPAL gel implantation, suggesting it is an easy-to-use, one-step method of cartilage tissue repair circumventing the need to harvest donor cells.Cite this article: Bone Joint J 2023;105-B(8):880–887.
Total femoral arthroplasty for non-oncological indications
Authors: Murray James , Jeyapalan Rathan , Davies Michael , Sheehan Ciara , Petrie Michael , Harrison Tim 
Published: August 2023

AimsTotal femoral arthroplasty (TFA) is a rare procedure used in cases of significant femoral bone loss, commonly from cancer, infection, and trauma. Low patient numbers have resulted in limited published work on long-term outcomes, and even less regarding TFA undertaken for non-oncological indications. The aim of this study was to evaluate the long-term clinical outcomes of all TFAs in our unit.MethodsData were collected retrospectively from a large tertiary referral revision arthroplasty unit’s database. Inclusion criteria included all patients who underwent TFA in our unit. Preoperative demographics, operative factors, and short- and long-term outcomes were collected for analysis. Outcome was defined using the Musculoskeletal Infection Society (MSIS) outcome reporting tool.ResultsOverall, 38 TFAs were identified. The mean age was 73 years (42 to 80). All patients underwent TFA for non-oncological indications, most commonly as a consequence of infection (53%) and periprosthetic fracture (26%). The mean follow-up time was ten years (0 to 26); 63% of TFAs were considered a success based upon the MSIS outcome reporting tool. The mean time between TFA and death was 8.5 years (0.2 to 19.2), with two patients dying within one year of surgery. Within the cohort, 66% suffered at least one complication, dislocation being most common (37%); 55% of the total cohort required at least one subsequent operation. In total, 70% of TFAs undertaken for infection were considered infection-free at time of final follow-up. The percentage of mobile patients improved from 52% to 65% between pre- and postoperation, with all patients being able to at least transfer from bed to chair at time of final review.ConclusionThis study is the largest in the UK assessing the use of TFA in patients with bone loss secondary to non-oncological conditions. It demonstrates that TFA has a significant complication profile, however it is favourable in terms of mortality and rehabilitation when compared to amputation and disarticulation.Cite this article: Bone Joint J 2023;105-B(8):888–894.
Influence of gadolinium, field-strength and sequence type on quantified perfusion values in phase-resolved functional lung MRI
Authors: Glandorf Julian , Brunzema Fynn , Klimeš Filip , Behrendt Lea , Voskrebenzev Andreas , Gutberlet Marcel , Wernz Marius M. , Grimm Robert , Wacker Frank , Vogel-Claussen Jens 
Published: August 2023

Purpose
The purpose of this study is to evaluate the influences of gadolinium-based contrast agents, field-strength and different sequences on perfusion quantification in Phase-Resolved Functional Lung (PREFUL) MRI.

Materials and methods
Four cohorts of different subjects were imaged to analyze influences on the quantified perfusion maps: 1) at baseline and after 2 weeks to obtain the reproducibility (26 COPD patients), 2) before and after the administration of gadobutrol (11 COPD, 2 PAH and 1 asthma), 3) at 1.5T and 3T (12 healthy, 4 CF), and 4) with different acquisition sequences spoiled gradient echo (SPGR) and balanced steady-state free precession (bSSFP) (11 COPD, 7 healthy). Wilcoxon-signed rank test, Bland-Altman plots, voxelwise Pearson correlations, normalized histogram analyses with skewness and kurtosis and two-sample Kolmogorov-Smirnov tests were performed. P value ≤ 0.05 was considered statistically significant.

Results
In all cohorts, linear correlations of the perfusion values were significant with correlation coefficients of at least 0.7 considering the entire lung (P<0.01). The reproducibility cohort revealed stable results with a similar distribution. In the gadolinium cohort, the quantified perfusion increased significantly (P<0.01), and no significant change was detected in the histogram analysis. In the field-strength cohort, no significant change of the quantified perfusion was shown, but a significant increase of skewness and kurtosis at 3T (P = 0.01). In the sequence cohort, the quantified perfusion decreased significantly in the bSSFP sequence (P<0.01) together with a significant decrease of skewness and kurtosis (P = 0.02). The field-strength and sequence cohorts had differing probability distribution in the two-sample Kolmogorov-Smirnov tests.

Conclusion
We observed a high susceptibility of perfusion quantification to gadolinium, field-strength or MRI sequence leading to distortion and deviation of the perfusion values. Future multicenter studies should strictly adhere to the identical study protocols to generate comparable results.
Study of the dependence of the natural frequencies of a rotor system with a vertically positioned rotor on the preload
Authors: Gasparov Erik S. , Marcosyan Gevorg A. , Kazakova Olga Yu. 
Published: August 2023

The article discusses the possibility of using a method for determining the preload force for trust and radial bearings of spindle assemblies for high-speed milling. Previously, a method was developed and tested for determining the preload force of bearing supports on high-speed grinding electrospindles with a horizontal spindle.
The object of study is a support with angular contact bearings 7004 ACD_P4A SKF and a vertical rotor. An information-measuring system has been developed, which consists of PCB 352C34 vibration acceleration sensors, a Vishay 614 force sensor, an NI-cRIO-9056 controller, NI 9250, NI 9237 and NI 9481 modules, and software written in the National Instruments Labview language.
The system of test actions has been improved due to its automation. Test effects began to be carried out using a solenoid with a core, which was controlled by an NI controller and developed software. Due to this, the same time delay was formed between the test action and the start of recording the vibration acceleration signal.
Vibration acceleration signals are obtained for the entire preload range. To study the controllability of the unit, two vibration acceleration sensors were used: with a parallel and perpendicular arrangement of the axes of the direction of vibration and test action. For the first and second groups of vibration accelerations, spectral transformations were carried out, and the amplitude-frequency characteristics of the assembly were obtained for the entire range of preload values.
As a result of the work, it was concluded that the presented methodology and criteria are applicable to high-speed milling spindle assemblies with a vertical rotor. It is also shown that this technique can be automated.
Die Involution der Verwandlung. Posthumanistische Denkfiguren in Elias Canettis "Masse und Macht"
Authors: Schott Hans-Joachim 
Published: August 2023

In seinem philosophischen Hauptwerk Masse und Macht suspendiert Elias Canetti die für die abendländische Metaphysik zentrale Differenz von Natur und Kultur, indem er im Anschluss an Friedrich Nietzsche das menschliche Verhältnis zur belebten und unbelebten Natur unter dem Begriff der Verwandlung diskutiert, der den dionysischen Prozess einer psychophysischen Meta- morphose bezeichnet. Die Verwandlung verbindet intensive Affekte, materielle Partikel und die freie Variation dichter Zeichen zu einem symbolischen Gefüge, das einen transversalen Kommunikations- und Austauschprozess zwischen dem menschlichen und animalischen Organismus anstößt. Dieses postanthropozentrische Erkenntnismodell entfaltet Canetti auf Basis einer phänomenologischen Annäherung an psychotische Grenzerfahrungen. Während er das schizoide Erleben intensiver Affektströme als ein paradigmatisches Beispiel für den gewaltfreien Austausch des Menschen mit der Natur betrachtet, erkennt er in den Krankheitsmustern der Paranoia die grundlegenden Strukturen der Macht wieder, die die Verwandlung zugunsten einer instrumentellen Beherrschung der Natur und der sozialen Interaktionen unterbinden. Die Paranoia der Macht ist für Canetti zugleich die Paranoia eines seit Aristoteles tief in der abendländischen Philosophie- und Wissenschaftsgeschichte verankerten Rationalitätskonzepts, das das Menschliche in Abgrenzung zu der es umgebenden Natur zu definieren versucht.
Flussers Schrift. Eine Schreib-Szene des zwanzigsten Jahrhunderts
Authors: Hiller Moritz 
Published: August 2023

Anhand eines Begriffs von Schreib-Szenen (Campe) ist der Beitrag mit dem Zustandekommen, der Ausgestaltung und den Implikationen von Vilém Flussers Hauptwerk Die Schrift. Hat Schreiben Zukunft? befasst, das in seinem Erscheinungsjahr 1987 nicht nur als gedrucktes Buch, sondern auch als frühe interaktive Digitalversion auf den Markt kam. Die Analyse legt einen vielschichtigen Selbstbezug von Inhalt, Form und Material an der Schwelle zur Jahrtausendwende offen, der die Grenze zwischen menschlicher und maschineller Autorschaft wie Subjektivität nicht nur zum Thema hat, sondern selber Symptom und Ort ihrer Aushandlung ist.
Disruptive Innovation oder Design? Posthumanistische Perspektiven auf die Prometheus-Figur in Literatur- und Arbeitsdiskursen
Authors: Heinritz Alena 
Published: August 2023

Als Schöpferfigur wird Prometheus in Überlegungen über Literatur angeführt; als Bild für den autonomen Menschen, der sich seine Welt durch Arbeit selbst schafft, illustriert die Figur Debatten über die Arbeit des Menschen. Seit Ihab Hassans Text Prometheus as Performer: Toward a Posthumanist Culture (1977) ist die Figur des Prometheus eng mit dem Konzept des Posthumanismus verbunden (Franssen 2014). Wichtig sind hier besonders Überlegungen zur „disruptiven Innovation“ (Schumpeter), Innovation beruhe immer auf Zerstörung. Demgegenüber stehen Latours Überlegungen von Design als Werk eines „vorsichtigen Prometheus“ (Latour 2008). Sowohl „Literatur“ als auch „Arbeit“ beschreibt ein Verhältnis des Menschen zur Welt, dessen Konzeption dem historischen Wandel unterworfen ist. Beide Verhältnisse werden diskursiv geprägt. Der Beitrag geht der Frage nach, wie diese Verhältnisse in literarischen Texten mit Referenz auf die Prometheus-Figur ausgearbeitet werden. Der Beitrag beschäftigt sich mit Texten, in denen die Prometheus-Figur für eine Reflexion über Literatur selbst und über Vorstellungen von Arbeit und Produktion herangezogen wird: entweder als disruptive Innovation oder als vorsichtiges Design.
The Eponyms of the Babylonian War of Tukultī-Ninurta I
Authors: Bloch Yigal 
Published: August 2023

Abstract
Following the recent reconstruction of the order of eponyms in the Dūr-Katlimmu archive by Nahm, this study considers the eponyms of the period in which Tukultī-Ninurta I waged war for domination of Babylonia, from his 13th regnal year onward. It is argued that recently published evidence supports the identification of the eponymy of Etel-pī-Aššur as the year in which Kaštiliaš IV of Babylonia was captured, and that the eponymy of Ellil-nādin-apli is to be placed three years later. The campaign to the lands between the Tigris and the Zagros, undertaken by Tukultī-Ninurta I in the eponymy of Ellil-nādin-apli, was probably directed against the power base of Kadašman-Ḫarbe II, including the city of Lubdu which then passed under Assyrian control. Following the dethronement of Kadašman-Ḫarbe II, Tukultī-Ninurta I maintained closer control over Babylonia, which did not prevent the king of Elam from putting an end to the reign of the Assyrian vassal Adad-šuma-iddina in the 22nd regnal year of Tukultī-Ninurta I.
Resizing Phrygia: Migration, State and Kingdom
Authors: Summers Geoffrey D. 
Published: August 2023

Abstract
This paper considers the concept of Phrygia, its origins at the cusp of the Early Iron Age, the beginning of the process of state formation marking the start of the Middle Iron Age and the possible development of a large unified kingdom under Midas son of Gordias. Secondly, the paper turns to consider the aftermath of the Phrygian state following the death of Midas and the period of Lydian hegemony together with the establishment of a new Phrygian petty kingdom east of the Kızılırmak (the Red River, the classical Halys River) in the first half of the 6th century BCE. In order to assess the extent of the territory of Phrygia, it has been necessary to consider evidence for neighbouring polities, particularly the Neo-Hittite kingdoms to the south and ‘Cappadocia’ to the southeast and east. Two maps graphically illustrate the principal suggestions.
Association of ADRB2 gene polymorphisms and intestinal microbiota in Chinese Han adolescents
Authors: Xu Shanrong , Liu Wenqi , Gong Li , Li Xinyang , Chu Wenwen , Han Meng , Shi Shuiqin , Zhou Duoqi 
Published: August 2023

Abstract
Gut microbiota are closely related to health, and the β2-adrenergic receptor (ADRB2) gene is associated with gastrointestinal diseases. However, little is known about the relationship between ADRB2 gene polymorphisms and intestinal microbiota. In the present study, we aimed to explore the relationship between ADRB2 gene polymorphisms and gut microbiota in Chinese Han adolescents. Data analysis showed that the relative abundance, PICRUSt function prediction, and Chao1 and ACE indices of gut microbiota were significantly different between males and females (P < 0.05). The rs1042711 was positively associated with the relative abundance of Actinobacteria, Coriobacteriia, Bifidobacteriales, Erysipelotrichi, and Erysipelotrichales. The rs12654778 was negatively associated with Bacilli, Lactobacillales, Bacteroidaceae, and Bacteroides. rs1042713 was positively associated with Lactobacillales and Bifidobacteriales. The rs1042717 was positively associated with Bifidobacteriales and negatively associated with Veillonellaceae. The rs1042719 was negatively associated with Erysipelotrichi and Erysipelotrichales and positively associated with Erysipelotrichi, Erysipelotrichales, Bifidobacteriales, and Ruminococcaceae in females. The rs1801704 was positively associated with Erysipelotrichi, Erysipelotrichales, Bifidobacteriales, Actinobacteria, Coriobacteriia, and Bifidobacteriales. The rs2053044 was positively associated with Ruminococcaceae, Dialister, Firmicutes, Clostridia, Clostridiales, Bifidobacteriales, and Faecalibacterium and negatively associated with Bacilli, Lactobacillales, Lachnospiraceae, and Porphyromonadaceae (P < 0.05). These results suggested that the relative abundance, diversity, and PICRUSt function predictions of male and female gut microbiomes differ significantly and that ADRB2 gene polymorphisms were associated with gut microbiome abundance in Chinese Han adolescents.