bluuebunny/crossref_metadata_2025_split huggingface dataset:
The low surface thermal inertia of the rapidly rotating near-Earth asteroid 2016 GE1
Authors: Fenucci Marco , Novaković Bojan , Marčeta Dušan 
Published: June 2023

Context. Asteroids smaller than about 100 m in diameter are observed to rotate very fast, with periods often much shorter than the critical spin limit of 2.2 h. Some of these super-fast rotators can also achieve a very large semimajor axis drift induced by the Yarkovsky effect, which, in turn, is determined by internal and surface physical properties.
Aims. We consider here a small super-fast-rotating near-Earth asteroid, designated as 2016 GE1. This object rotates in just about 34 s, and a large Yarkovsky effect has been determined from astrometry. By using these results, we aim to constrain the thermal inertia of the surface of this extreme object.
Methods. We used a recently developed statistical method to determine the thermal properties of near-Earth asteroids. The method is based on the comparison between the observed and the modeled Yarkovsky effect, and the thermal conductivity (inertia) is determined via a Monte Carlo approach. Parameters of the Yarkovsky effect model are fixed if their uncertainty is negligible, modeled with a Gaussian distribution of the errors if they are measured, or deduced from general properties of the population of near-Earth asteroids when they are unknown.
Results. Using a well-established orbit determination procedure, we determined the Yarkovsky effect on 2016 GE1 and confirm a significant semimajor axis drift rate. Using a statistical method, we show that this semimajor axis drift rate can only be explained by low thermal inertia values below 100 J m−2 K−1 s−1/2. We benchmarked our statistical method using the well-characterized asteroid Bennu and find that only knowing the semimajor axis drift rate and the rotation period is generally insufficient for determining the thermal inertia. However, when the statistical method is applied to super-fast rotators, we find that the measured Yarkovsky effect can be achieved only for very low values of thermal inertia: namely, 90% of the probability density function of the model outcomes is contained at values smaller than 100 J m−2 K−1 s−1/2.
Conclusions. We propose two possible interpretations for the extremely low thermal inertia of 2016 GE1: a high porosity or a cracked surface, or a thin layer of fine regolith on the surface. Though both possibilities seem somewhat unexpected, this opens up the possibility of a subclass of low-inertia, super-fast-rotating asteroids.
Structure of iso-density sets in supersonic isothermal turbulence
Authors: Thiesset F. , Federrath C. 
Published: June 2023

Context. The gas density structure of the cold molecular phase of the interstellar medium is the main controller of star formation.
Aims. A theoretical framework is proposed to describe the structural content of the density field in isothermal supersonic turbulence.
Methods. It makes use of correlation and structure functions of the phase indicator field defined for different iso-density values. The relations between these two-point statistics and the geometrical features of iso-density sets such as the volume fraction, the surface density, the curvature, and fractal characteristics are provided. An exact scale-by-scale budget equation is further derived revealing the role of the turbulent cascade and dilation on the structural evolution of the density field. Although applicable to many flow situations, this tool is here first invoked for characterising supersonic isothermal turbulence, using data from the currently best-resolved numerical simulation.
Results. We show that iso-density sets are surface fractals rather than mass fractals, with dimensions that markedly differ between dilute, neutral, and dense regions. The surface–size relation is established for different iso-density values. We further find that the turbulent cascade of iso-density sets is directed from large towards smaller scales, in agreement with the classical picture that turbulence acts to concentrate more surface into smaller volumes. Intriguingly, there is no range of scales that complies with a constant transfer rate in the cascade, challenging our fundamental understanding of interstellar turbulence. Finally, we recast the virial theorem in a new formulation drawing an explicit relation between the aforementioned geometrical measures and the dynamics of iso-density sets.
A multi-band AGN-SFG classifier for extragalactic radio surveys using machine learning
Authors: Karsten J. , Wang L. , Margalef-Bentabol B. , Best P. N. , Kondapally R. , La Marca A. , Morganti R. , Röttgering H. J. A. , Vaccari M. , Sabater J. 
Published: June 2023

Context.Extragalactic radio continuum surveys play an increasingly more important role in galaxy evolution and cosmology studies. While radio galaxies and radio quasars dominate at the bright end, star-forming galaxies (SFGs) and radio-quiet active galactic nuclei (AGNs) are more common at fainter flux densities.Aims.Our aim is to develop a machine-learning classifier that can efficiently and reliably separate AGNs and SFGs in radio continuum surveys.Methods.We performed a supervised classification of SFGs versus AGNs using the light gradient boosting machine (LGBM) on three LOFAR Deep Fields (Lockman Hole, Boötes, and ELAIS-N1), which benefit from a wide range of high-quality multi-wavelength data and classification labels derived from extensive spectral energy distribution (SED) analyses.Results.Our trained model has a precision of 0.92±0.01 and a recall of 0.87±0.02 for SFGs. For AGNs, the model performs slightly worse, with a precision of 0.87±0.02 and a recall of 0.78±0.02. These results demonstrate that our trained model can successfully reproduce the classification labels derived from a detailed SED analysis. The model performance decreases towards higher redshifts, which is mainly due to smaller training sample sizes. To make the classifier more adaptable to other radio galaxy surveys, we also investigate how our classifier performs with a poorer multi-wavelength sampling of the SED. In particular, we find that the far-infrared and radio bands are of great importance. We also find that a higher signal-to-noise ratio in some photometric bands leads to a significant boost in the model performance. In addition to using the 150 MHz radio data, our model can also be used with 1.4 GHz radio data. Converting 1.4 GHz to 150 MHz radio data reduces the performance by ~4% in precision and ~3% in recall.
Diagnosis of Pulmonary Embolism in Pregnancy
Authors: Fitzsimmons Jack , Hart Laura , Oliver Emily , Mulla Wadia 
Published: June 2023

Pulmonary embolism (PE) is a significant cause of obstetric morbidity and mortality. However, overdiagnosis related to excessive use of diagnostic testing is also associated with long-term major health issues, including impact on future pregnancies and subsequent health care. Accurate diagnosis of PE depends on the knowledge of prevalence of PE in the pregnant population, the a priori probability of a PE based on specific findings in a given patient, and understanding of the accuracy of computed tomography pulmonary angiography (CTPA), the dominant diagnostic modality employed for this diagnosis. Venous thromboembolism is widely considered to be more common in pregnancy. However, this term includes both deep venous thrombosis as well as PE. While the former appears to be more common, published data on the prevalence of PE in pregnancy show little or no increase relative to the general population. Given the published data on the sensitivity and specificity of CTPA, a positive reading is more likely to be a false positive unless the probability of a PE in a given patient is at least 5% (a 200-fold increase from baseline). Doubling the probability to 10% (a 400-fold increase) only improves the positive predictive value to approximately 67%. Strategies to refine the a priori probability of a PE in a given patient are detailed, including scoring systems and D-dimer measurements. A careful history and physical examination and thoughtful development of a differential diagnosis are key elements of clinical practice and should include both the likelihood of each possible diagnosis and the accuracy of diagnostic modalities. This approach should precede the application of a given algorithm. Such a structured approach can decrease utilization and limit false positive diagnoses without increasing morbidity or mortality.
Key Points
More Is Not Merrier: Increasing Numbers of All-Inside Implants Do Not Correlate with Higher Odds of Revision Surgery
Authors: Oosten James D. , DiBartola Alex C. , Wright Jonathan C. , Cavendish Parker A. , Milliron Eric M. , Magnussen Robert A. , Duerr Robert A. , Kaeding Christopher C. , Flanigan David C. 
Published: June 2023

AbstractThe purpose of this study was to evaluate the relationship between the number of all-inside meniscal repair implants placed and the risk of repair failure. We hypothesized that the use of higher numbers of all-inside meniscus repair implants would be associated with increased failure risk. A retrospective chart review identified 351 patients who underwent all-inside meniscus repair between 2006 and 2013 by a sports medicine fellowship–trained orthopaedic surgeon at a single institution. Patient demographics (age, body mass index [BMI], sex) and surgical data (number of implants used, concomitant anterior cruciate ligament reconstruction [cACLR], and tear type/size/location) were recorded. Patients who received repairs in both menisci or who had follow-up < 1-year postoperatively were excluded. Repair failure was identified through chart review or patient interviews defined as a revision surgery on the index knee such as partial meniscectomy, total knee arthroplasty, meniscus transplant, or repeat repair. Logistic regression modeling was utilized to evaluate the relationship between the number of implants used and repair failure. A total of 227 all-inside meniscus repairs were included with a mean follow-up of 5.0 ± 3.0 years following surgery. Repair failure was noted in 68 knees (30.3%)—in 28.1% of knees with fewer than four implants and in 35.8% of knees with four or more implants (p = 0.31). No significant increase in failure was observed with increasing number of all-inside medial (odds ratio [OR]: 1.15; 95% confidence interval [CI]: 0.79–1.7; p = 0.46) or lateral (OR: 0.86; 95% CI: 0.47–1.57; p = 0.63) implants after controlling for patient age, BMI, cACLR, tear type, or size. Tears of the lateral meniscus located in the red–white and white–white zones had lower odds of failure (OR: 0.14; 95% CI: 0.02–0.88; p = 0.036) than tears within the red–red zone, and patients with cACLR had lower odds of repair failure (OR: 0.40; 95% CI: 0.18–0.86, p = 0.024) than those without. The number of all-inside implants placed during meniscus tear repair did not affect the likelihood of repair failure leading to reoperation after controlling for BMI, age, tear type, size, location, and cACLR.
Level of Evidence III.
A Novel Technique Using the Dorsal Capsule of the Distal Radioulnar Joint for Extensor Carpi Ulnaris Tendon Subsheath Reconstruction
Authors: Png Christina , Choudhury Muntasir Mannan , Chin Andrew Yuan Hui 
Published: June 2023

Abstract
Background Ulnar-sided wrist pain is a common problem encountered by hand surgeons. Symptomatic recurrent subluxation of the extensor carpi ulnaris (ECU) tendon has become increasingly recognized as one of the pathological conditions leading to ulnar-sided wrist pain. Surgical reconstruction of the subsheath is usually needed. ECU tendon subsheath reconstruction with the periosteal flap was first described by Schlesinger in 1907. Since then, various other techniques have been widely used. We describe a technique of ECU subsheath reconstruction using the dorsal capsule of the distal radioulnar joint (DRUJ).
Description of Technique Two hand surgeons performed the surgeries with the same steps taken each time. A detailed description of our surgical technique, with the dorsal capsule of the DRUJ used to reconstruct the ECU tendon subsheath, is illustrated.
Patient and Methods Patients who presented with symptomatic ECU instability despite conservative treatment or who have failed primary subsheath repair were offered this surgical option. Patients were followed up postoperatively for an average duration of 6.7 months in our outpatient clinics for assessment of wrist function. The surgical outcomes were reviewed and graded with the Modified Mayo Wrist Score (MMWS).
Results All but one of the seven patients had an overall improvement in their range of movement of the wrist, grip strength, and pain scores. Four patients had excellent outcomes on the MMWS, one of whom had an asymptomatic recurrence seen on dynamic ultrasound. Two patients required subsequent surgeries: one had an excellent outcome and the other had a poor outcome on the MMWS.
Conclusion We present our first seven cases of ECU subsheath reconstruction with the dorsal capsule of the DRUJ. Our results in the short term have been satisfactory. The technique does not disrupt the integrity of the extensor retinaculum, which is essential for optimal extensor tendon function, and can also be considered as an option to salvage failed procedures.
Utility of Hematological Parameters in Early Diagnosis of Neonatal Sepsis in Comparison to C-Reactive Protein
Authors: Joshi Divya , Padma Shetty K. , K. Jayaprakash Shetty , Goel Shreya , Hidangmayum Abena 
Published: June 2023

Abstract
Background Neonatal sepsis is the most common cause of neonatal mortality and morbidity. As neonatal sepsis presents with subtle symptoms and signs, decision to start empirical antibiotics is most often based on risk profile. Hematological parameters and C-reactive protein (CRP) are routinely done as a part of sepsis screening, but isolation of microorganism on blood culture is the gold standard for diagnosis of sepsis.
Methodology One-hundred neonates with suspected sepsis were studied and their hematological parameters, hematological scoring system (HSS), and CRP were correlated to blood culture.
Results Among the study population, immature to total neutrophil count (I:T) ratio had the best sensitivity (94.1%) and negative predictive value (83.3%), followed by HSS with a sensitivity of 64.7% and negative predictive value of 68.4%, whereas CRP was more specific (75.9%).
Conclusion HSS and CRP are good predictors of diagnosis of neonatal sepsis. I:T ratio had the best sensitivity and negative predictive value.
Neuropsychological and quality of life outcomes in PKU patients: expert recommendations of assessment tools in Brazil
Authors: Schwartz Ida Vanessa Doederlein , Quesada Andrea Amaro , Ribeiro Erlane Marques , Martins Ana Maria , Vilela Daniel Reda Fenga , Pessoa André 
Published: June 2023

Abstract
Background Phenylketonuria (PKU) is an inborn error of metabolism caused by deficient activity of phenylalanine hydroxylase. In Brazil, the National Neonatal Screening Program enables early treatment of patients with PKU, which prevents them from developing severe neurological damage and mental disabilities. However, between 20 and 30% of early-treated patients with PKU present focal cognitive deficits, including deficits in working memory, processing speed, and psychiatric symptoms such as anxiety, depression, and attention deficit hyperactivity disorder (ADHD). Therefore, age-specific neuropsychiatric and cognitive tests are important components of PKU patient care. To date, there are no officially approved guidelines or recommendations of tools in Portuguese validated for use in Brazil that could be applied to assess these parameters in patients with PKU.
Objective To recommend tools validated for use in Brazil that can be used in daily clinical practice to assess quality of life and neuropsychological outcomes in patients with PKU.
Methods Six Brazilian experts discussed about eligible tools based on their clinical experience, the feasibility of their use in clinical routines, and their availability in public health services. Before the meeting, an independent review of the literature was conducted to identify the currently validated tools in Brazil, using the MEDLINE and SciELO databases.
Results The experts recommended nine tools to assess quality of life (Peds-QL, SF-36 or WHOQOL-bref), executive function (BRIEF or Bayley-III), IQ (SONR 2½-7[a] or WASI) and ADHD (MTA-SNAP-IV and ASRS).
Conclusion These instruments may be easily incorporated into clinical practice and improve the quality of multidisciplinary care of patients with PKU.
Effects of Transfixation Pin Positioning on the Biomechanical Properties of Acrylic External Skeletal Fixators in a Fracture Gap Model
Authors: Lahiani Joachim , Freire Mila , Montasell Xavier , Juette Tristan , Gagnon Dominique 
Published: June 2023

AbstractObjective The aim of this study was to evaluate the biomechanical effects of transfixation pin positioning in acrylic columns of external skeletal fixators (ESF).Study Design Twenty-four type I acrylic ESF were built simulating a fracture gap-model. Transfixation pins were placed centric (n = 12) or eccentric at ¼ of the column diameter (n = 12) in the acrylic columns. Six constructs from each group were subjected to axial compression and four-point bending tests. Stiffness, yield load and mode of failure were recorded.Results Stiffness was not influenced by centring (p = 0.373), but it was higher in four-point bending than in axial compression (p < 0.001). Pin positioning had no influence on the yield (p = 0.535) and failure loads (p = 0.715) in axial compression, nor on the yield load in bending (p = 0.135). Eccentric pin positioning decreased failure loads by 28% in bending (p < 0.001).Conclusion Eccentric position of transfixation pins within the acrylic columns alters the biomechanical properties of type I ESF constructs. While acrylic offers several advantages, when forming the columns, frame strength will be optimized if pins are centrally located.
In Silico ADMET and Molecular Interaction Profiles of Phytochemicals from Medicinal Plants in Dakshina Kannada
Authors: James Jainey P. , Ail Puneeth Deepak , Crasta Lenisha , Kamath Rakshith Sudheer , Shura M. H. , T.J Sindhu 
Published: June 2023

AbstractThe success or failure of a potential drug depends on its absorption, distribution, metabolism, excretion and toxicity (ADMET) characteristics, and these features are usually rate-limiting in the drug development process. Hence, it is essential to know about the predicted ADMET properties of the most promising leads to avoid the risk of late-stage attrition. This project focuses on in silico screening of ADMET properties of phytochemicals found in Dakshina Kannada's medicinal plants, which include Tinospora cordifolia, Azadirachta indica, Ocimum sanctum, and Plectranthus amboinicus, mainly known for their antimicrobial properties.The physicochemical properties, bioactivity scores, ADMET, and molecular interactions of the selected phytoconstituents were determined by QikProp, Molinspiration, ADMETlab 2.0, ProTox-II, and GLIDE. In addition, molecular docking checked for their binding interactions with target proteins 1JIJ and 4 HOE of Staphylococcus aureus and Candida albicans, respectively, as they were well known for their antimicrobial properties. In this studies, rosmarinic acid was well interacted phytochemical with both target proteins and has highest docking score.The physicochemical properties showed that all compounds fell under the recommended molecular weight, volume, and polar surface area range. Xanosporic acid violated two rules of Lipinski's Rule of Five, indicating that it may have problems with oral bioavailability. The ADME properties for most of the phytocompounds were within the recommended ranges; hence, they are promising candidates for drug development. Most phytoconstituents showed good bioactivity scores, indicating they have good druglikeness properties. On the analysis of the toxicity, most of the phytoconstituents were found to be noncarcinogenic and nonmutagenic. Therefore, this data can further be utilized as primary tools for determining the biological actions of these plants.Xanosporic acid was found to violate two out of three rules of Lipinski. Similarly, ursolic acid and oleanolic acid also showed a few undesirable properties. All other compounds otherwise showed desirable properties and hence are promising candidates for drug development. This data can be further utilized as primary tool for determining the biological actions of the plants.
Prevalence and Impact of HMOX1 Polymorphism (rs2071746: A > T) in Indian Sickle Cell Disease Patients
Authors: Pandey Hareram , Singh Kanwaljeet , Ranjan Ravi , Dass Jasmita , Tyagi Seema , Seth Tulika , Saxena Renu , Mahapatra Manoranjan 
Published: June 2023

Abstract
Introduction Fetal hemoglobin (HbF) levels play significant role in lowering down the morbidity and mortality in sickle cell disease (SCD) patients. Coinheritance of heme oxygenase-1 (HMOX1) rs2071746:A > T polymorphism may contribute to variable HbF levels in Indian SCD patients.
Objective This study was aimed to evaluate the role of HMOX1 polymorphism and its impact on HbF level in Indian SCD patients.
Materials and Methods One-hundred twenty confirmed cases of SCD and 50 healthy controls were recruited. Their mean age was 11.5 ± 8.6 years (range: 3–23 years). Quantification of Hb, HbA2, HbF, and HbS was done by capillary zone electrophoresis. Allele-specific polymerase chain reaction was used to genotype HMOX1 (rs2071746:A > T) gene polymorphism.
Results Out of the 120 cases of SCD, 65 were hemoglobin sickle-shaped (HbSS) and 55 were sickle-beta thalassemia (Sβ). Out of 65 HbSS patients, 29 (44.6%) were heterozygous (AT), 20 (30.76%) were homozygous (TT), and 16 (24.61%) were found wild-type (AA) genotype. Out of 55 Sβ, 22 (40%) were heterozygous, 18 (32%) were homozygous and 15 (28%) were wild-type. Patients carrying HMOX1 (rs2071746:A > T), AT, and TT genotypes had less anemia, painful crisis, splenomegaly, hepatomegaly, jaundice, and blood transfusion. HbF level was found higher in TT genotype (in HbSS the HbF levels was 25.1 ± 4.4; in sickle-beta thalassemia the HbF levels was 36.1 ± 4.7) than wild-type(AA) and was statistically significant (p-value <0.001).
Conclusion The TT genotype of the rs2071746:A > T polymorphism was associated with increased levels of Hb F (p < 0.001). It can serve as a HbF modifier in Indian sickle cell diseases patients.
Evaluation of Surgical Technique and Clinical Results of a Procedure-Specific Fixation Method for Tibial Tuberosity Transposition in Dogs: 37 Cases
Authors: Onis David , Entoft Jessica , Wouters Erik G.H. , Skytte Ditte , Bruining-Staal Karin , Vernooij Johannes C.M. , Meij Björn Petrus 
Published: June 2023

Abstract
Objective The aim of this study was to describe the use of a procedure-specific fixation method for tibial tuberosity transposition and report clinical outcome.
Study Design This is a multi-institutional case series, evaluating 37 cases that were treated surgically for medial patellar luxation (MPL) and in which the tibial tuberosity transposition (TTT) was performed using the Rapid Luxation Plating System (RLPS). Surgical technique, implants, clinical outcome, and complications are reported.
Results Surgery was successfully performed in dogs weighing 2.5 to 36.2 kg. Postoperative minor complications occurred in 13 cases (35%) and major complications occurred in 3 cases (8%). No implant-related complications or tibial tuberosity avulsions or fractures were seen. Outcome related to surgery was good or excellent in all cases.
Conclusion The RLPS for TTT provides a feasible technique in a large range of patients with MPL and lowers the occurrence of implant-related complications and tibial tuberosity avulsion or fracture.