bluuebunny/crossref_metadata_2025_split huggingface dataset:
Understanding Digital Mental Health Needs and Usage With an Artificial Intelligence–Led Mental Health App (Wysa) During the COVID-19 Pandemic: Retrospective Analysis
Authors: Sinha Chaitali , Meheli Saha , Kadaba Madhura 
Published: December 2022

Background
There has been a surge in mental health concerns during the COVID-19 pandemic, which has prompted the increased use of digital platforms. However, there is little known about the mental health needs and behaviors of the global population during the pandemic. This study aims to fill this knowledge gap through the analysis of real-world data collected from users of a digital mental health app (Wysa) regarding their engagement patterns and behaviors, as shown by their usage of the service.

Objective
This study aims to (1) examine the relationship between mental health distress, digital health uptake, and COVID-19 case numbers; (2) evaluate engagement patterns with the app during the study period; and (3) examine the efficacy of the app in improving mental health outcomes for its users during the pandemic.

Methods
This study used a retrospective observational design. During the COVID-19 pandemic, the app’s installations and emotional utterances were measured from March 2020 to October 2021 for the United Kingdom, the United States of America, and India and were mapped against COVID-19 case numbers and their peaks. The engagement of the users from this period (N=4541) with the Wysa app was compared to that of equivalent samples of users from a pre–COVID-19 period (1000 iterations). The efficacy was assessed for users who completed pre-post assessments for symptoms of depression (n=2061) and anxiety (n=1995) on the Patient Health Questionnaire-9 (PHQ-9) and Generalized Anxiety Disorder-7 (GAD-7) test measures, respectively.

Results
Our findings demonstrate a significant positive correlation between the increase in the number of installs of the Wysa mental health app and the peaks of COVID-19 case numbers in the United Kingdom (P=.02) and India (P<.001). Findings indicate that users (N=4541) during the COVID period had a significantly higher engagement than the samples from the pre-COVID period, with a medium to large effect size for 80% of these 1000 iterative samples, as observed on the Mann-Whitney test. The PHQ-9 and GAD-7 pre-post assessments indicated statistically significant improvement with a medium effect size (PHQ-9: P=.57; GAD-7: P=.56).

Conclusions
This study demonstrates that emotional distress increased substantially during the pandemic, prompting the increased uptake of an artificial intelligence–led mental health app (Wysa), and also offers evidence that the Wysa app could support its users and its usage could result in a significant reduction in symptoms of anxiety and depression. This study also highlights the importance of contextualizing interventions and suggests that digital health interventions can provide large populations with scalable and evidence-based support for mental health care.
Optimización de rutas en la recolección de residuos tecnológicos
Authors: Lopez Miguel , Villagra Andrea , Pandolfi Daniel 
Published: December 2022

La creciente demanda en el uso las tecnologías de la información y comunicación han revolucionado nuestra vida cotidiana, sin embargo, han contribuido a aumentar las preocupaciones ambientales y sociales. La aceleración de factores como el agotamiento y escasez de recursos, daños ambientales, uso de agua y energía, y un incremento insostenible de desechos tecnológicos en zonas urbanas, se ha convertido en una preocupación para el gobierno. El sostenimiento del ritmo de consumo depende de estrategias que permitan el reciclaje de los desechos y el fortalecimiento de una economía circular realizando un cambio sistémico, en la investigación y la innovación, tanto tecnológica como logística.
Dada la importancia de la recolección y transporte de los residuos, abordamos en este trabajo la programación de la logística de recolección de residuos tecnológicos que corresponde al problema de enrutamiento de vehículos (Vehicle Routing Problem, VRP). Se aplican dos metaheurísticas poblaciones, el algoritmo genético celular (en inglés, Cellular Genetic Algorithm – cGA) y el algoritmo de Optimización basada en Colonia de Hormigas (en inglés, Ant Colony Optimization - ACO) usados en la generación de recorridos óptimos para la recolección de estos residuos. Además, se utilizan instancias de las ciudades de Caleta Olivia y Comodoro Rivadavia con diferentes escenarios de recolección. El algoritmo ACO muestra la obtención de las mejores rutas (las que minimizan los kilómetros recorridos) comparadas con las obtenidas por cGA. Se realizan análisis estadísticos que confirman estos resultados.
Botulinum toxin as an adjunct for severe Dupuytren’s contracture treated with collagenase injections
Authors:   Division of Plastic and Reconstructive Surgery, University of California, San Francisco, CA, USA, Denkler Keith A. , Cheng Justin ,   Division of Plastic and Reconstructive Surgery, University of California, San Francisco, CA, USA, Song Siyou ,   Division of Plastic and Reconstructive Surgery, University of California, San Francisco, CA, USA
Published: December 2022

Even with Dupuytren's proximal interphalangeal joint (PIPJ) contractures successfully released, volar flexor muscle memory can contribute to persistent contracture. We report using botulinum toxin (BoNTA) to the flexor digitorum superficialis muscle (FDS) to reduce flexor tone during recovery. Case Description. Two Collagenase clostridium histolyticum (CCH) injections were given to a patient with a -90° (PIPJ) contracture and a -35° degree distal interphalangeal joint (DIPJ) contracture. At the first CCH injection, 20 µ total of the Botulinum toxin was placed into the FDS muscle. Manipulation occurred at one week. A second injection of CCH followed by manipulation one week later occurred at two months, but no additional BoNTA was given. The final follow-up measurements at 53 months showed a PIPJ of -30° and a DIPJ of 0°. Total active motion improved from 140° to 240°. Outcomes of any treatment for severe Dupuytren's PIPJ contractures of the little finger are unpredictable and are often considered for staged external expansion or even salvage procedures. BoNTA injections weaken flexor tone in tendon repairs and for treating hypertonic muscles after strokes. Conclusion. We hypothesized that BoNTA injection could enhance the outcomes of DC treatment by inhibiting volar flexion forces during the recovery phase. The following case illustrates that using a BoNTA injection may have helped treat a severe PIPJ contracture. BoNTA injections need further research and controlled clinical trials to discover their proper role in Dupuytren's contractures treated via CCH injections, fasciotomies, and fasciectomies.
New onset severe ulcerative colitis following Ixekizumab therapy
Authors:   Gastroenterology Department, “Sf. Dimitrie” Hospital, Targu Neamt, Romania, Morosanu Alina Mihaela , Mihai Ioana Ruxandra ,   “Grigore T. Popa” University of Medicine and Pharmacy, Clinical Rehabilitation Hospital, 1st Rheumatology Clinic, Iasi, Romania, Rezus Ioana Irina ,   “Grigore T. Popa” University of Medicine and Pharmacy, Department of Dermatology, Iasi, Romania
Published: December 2022

Ixekizumab is one of the three biologic agents including Secukinumab and Brodalumab that targets the Interleukin-17 (IL-17) pathway to reduce inflammation in psoriasis and ankylosing spondylitis. In this report we present the case of 42-year-old woman, who was diagnosed with psoriasis and psoriatic arthritis. One week after first administration of Ixekizumab, she developed diffuse abdominal pain, bloody diarrhea (7-8 stools/day) and fever. Following imaging (colonoscopy, computed tomography) and laboratory investigations, she was diagnosed with acute severe ulcerative colitis complicated with toxic megacolon. The medical treatment (first corticotherapy, then infliximab) has failed and the patient needed emergency colectomy. Based on the immunological mechanisms and the observation from other studies, Ixekizumab should be considered an etiology for new-onset inflammatory bowel disease.
Pre-diabetes is associated with increased risk of heart failure among patients with atrial fibrillation
Authors: Huang Jia-Yi , Tse Yi-Kei , Li Hang-Long , Chen Cong , Zhao Chun-Ting , Liu Ming-Ya , Wu Mei-Zhen , Ren Qing-Wen , Yu Si-Yeung , Hung Denise , Li Xin-Li , Tse Hung-Fat , Lip Gregory Y.H. , Yiu Kai-Hang 
Published: December 2022

<p> </p>
<p><strong>Abstract</strong></p>
<p><strong>Objective: </strong>To evaluate the association between pre-diabetes and HF and the association of HF with changes in glycaemic status. </p>
<p><strong>Design and Methods: </strong>Patients newly diagnosed with AF between 2015 and 2018 were divided into 3 groups (normoglycaemia, pre-diabetes, and type 2 diabetes) according to their baseline glycaemic status. The primary outcome was incident HF. Fine and Gray model was applied, with death defined as the competing event. </p>
<p><strong>Results</strong>: Among 17,943 AF patients (mean age 75.5 years, 47% female), 3,711 (20.7%) had pre-diabetes and 10,127 (56.4%) had diabetes at baseline. Over a median follow-up of 4.7 years, 518 (14%) normoglycaemic, 646 (15.7%) pre-diabetic, and 1,795 (17.7%) diabetic patients developed HF. Pre-diabetes was associated with an increased risk of HF compared with normoglycaemic patients (subdistribution Hazard Ratio (SHR) =1.12, 95% confidence interval (CI): 1.03-1.22). In patients with pre-diabetes at baseline, 403 (11.1%) progressed to diabetes and 311 (8.6%) reversed to normoglycaemia at 2 years. Compared to those who remained pre-diabetic, patients who progressed to diabetes were associated with an increased risk of HF (SHR=1.50, 95% CI: 1.13-1.97), whereas those who reversed to normoglycaemia were associated with decreased risk (SHR=0.61, 95% CI: 0.42-0.94). </p>
<p><strong>Conclusions</strong>: Pre-diabetes was associated with an increased risk of HF in patients with AF. Compared with patients who remained pre-diabetic, those who progressed to diabetes at 2 years experienced an increased risk of HF, whereas those who reversed to normoglycaemia incurred a lower risk of HF. </p>
Pengaruh Budaya Kerja Dan Disiplin Terhadap Kinerja Pegawai Pada Dinas Kependudukan Dan Catatan Sipil Lampung Tengah
Authors: Mazni Afdal , Putri Tia Bela 
Published: December 2022

Tujuan penelitian ini adalah Untuk mengetahui pengaruh budaya kerja dan disiplin secara bersama-sama terhadap kinerja pegawai Pada Dinas Kependudukan dan Catatan Sipil Lampung Tengah. Desain penelitian ini adalah deskriptif. Populasi dalam penelitian ini adalah seluruh pegawai Pada Dinas Kependudukan dan Catatan Sipil Lampung Tengah. yang berjumlah 35 orang dan sekaligus sebagai sampel. Analisis data yang digunakan dalam penelitian ini adalah regresi linier berganda.
Hasil penelitian ini menunjukkan bahwa secara parsial Budaya kerja berpengaruh positif dan signifikan terhadap kinerja pegawai di Dinas Kependudukan dan Catatan Sipil Lampung Tengah diperoleh thitung(7.405)> nilai ttabel(1,697) taraf signifikan 0.000<.05. Disiplin berpengaruh positif dan signifikan terhadap kinerja pegawai di Dinas Kependudukan dan Catatan Sipil Lampung Tengah diperoleh thitung(2.657)> nilai ttabel(1,697) taraf signifikan 0.000<0.05 Hal tersebut berarti, jika komunikasi atau motivasi dapat dijalankan dengan baik maka kinerja juga akan mengalami peningkatan. Hasil membuktikan bahwa Budaya kerja dan disiplin berpengaruh positif dan signifikan terhadap kinerja pegawai pada Dinas Kependudukan dan Catatan Sipil Lampung Tengah diperoleh Fhitung(67.223 )> nilai Ftabel(3,32) taraf signifikan 0.000<0.05.
Hal tersebut berarti apabila komunikasi dapat dijalankan dengan baik, dan motivasi dapat ditingkatkan dengan baik maka kinerja juga akan mengalami peningkatan. Saran penelitian Kinerja pegawai Pada Dinas Kependudukan dan Catatan Sipil Lampung Tengah perlu ditingkatkan khususnya pada aspek kedisiplinan Hal tersebut hendaknya dapat dibenahi oleh pegawai dengan meningkatkan kesadarannya pada perannya dalam organisasi, serta organisasi hendaknya memberikan penegakan peraturan dan memberikan skor pada pegawai yang tidak disiplin.
Pengaruh Motivasi Kerja, Semangat Kerja, Kepribadian Dan Kompensasi Terhadap Produktifitas Kerja Pada Kantor PPPAPPKB Kota Metro Lampung
Authors: Rini Arum Puspita , Yateno Yateno 
Published: December 2022

Kantor PPPAPPKB Metro lampung memiliki permasalahan yang umum seperti halnya kinerja pegawai, dalam penelitian awal penulis menemukan berbagai macam permasalahan yang akan menjadi objek untuk diteliti. Beberapa masalah diantaranya adalah adanya pegawai yang kurang memiliki motivasi, semangat kerja, kepribadian, serta kompensasi yang sesuai dengan prosedur yang ditetapkan oleh lembaga guna meningkatkan produktivitas kerja para pegawai.
Jenis penelitian ini adalah kuantitatif. Sedangkan deskripsi dari riset ini ialah untuk mengetahui baik secara parsial maupun secara simultan dari variabel yang diteliti, dengan jumlah populasi sebanyak 75 responden serta pengambilan sampel sebesar 64 pegawai dan teknik sampling yang digunakan ialah random sampling. Tahapan yang dilakukan dengan cara observasi dan kuesioner dan dibantu dengan alat analisis melalui uji validitas, reliabilitas, serta regresi linier berganda.
Kesimpulan Secara simultan keempat variabel menunjukkan pengaruh dan signifikan terhadap produktivitas kerja, maka dalam penelitian ini yang membahas tentang motivasi kerja, semangat kerja, kepribadian, dan kompensasi terhadap produktivitas kerja sangat berkaitan penting dalam kehidupan di suatu organisasi atau lembaga/instansi.
Analisis Faktor-Faktor Yang Mempengaruhi Kinerja Karyawan Pada Pt. Japfa Comfeed Indonesia,Tbk. Lampung Tengah
Authors: Linda Wahyu Ama , Febriyanto Febriyanto 
Published: December 2022

This study aims to determine the effect of compensation, work ability and work environment together on employee performance at PT. Japfa Comfeed Indonesia, Tbk. Central Lampung. This type of research is quantitative research. Data obtained from the results of a questionnaire given to 28 respondents, namely employees of PT. Japfa Comfeed Indonesia, Tbk. Central Lampung. The analysis technique used is Data Requirements Testing, Analysis Requirements Testing and Hypothesis Testing. The results of this study indicate that the Compensation Variable (X1) has a value of t count (4.040) greater than t table (2.013) or it can be seen from the significance value of 0.000 <a = 0.05. Therefore, H0 is rejected and H1 is accepted, so the compensation variable (X1) has a positive and significant effect on employee performance (Y). Providing satisfactory compensation will make employees excited and enthusiastic at work. This of course will give a better performance effect. Workability variable (X2) has a value of t (2.830) greater than t table (2.013) or can be seen from the significance value of 0.001 <a = 0.05. Therefore, Ho is rejected and H2 is accepted, so that Job Ability has a positive and significant effect on employee performance. When employees are responsive in doing the work they are assigned to, it will have an impact on the resulting performance in accordance with company standards. Work Environment variable (X3) has a value of t (2.218) greater than t table (2.013) or it can be seen from the significance value of 0.028 <a = 0.05. Therefore, Ho is rejected and H3 is accepted, so the Work Environment (X3) has a positive and significant effect on employee performance (Y). The better and conducive the employee's work environment is, the greater the work comfort you will get.

Keywords: compensation, work ability and work environment, employee performance
LA PAROLA “PROGRESSO”: C’È VITA OLTRE LA MORTE? C’È VITA OLTRE LA GUERRA?
Authors: GIORGI Edoardo 
Published: December 2022

The Word "Progress": Is There Life Beyond Death? Is There Life Beyond War? This article’s purpose is to analyze as thoroughly as possible one of the most interesting dramas of the well-known French-Romanian dramatist Matei Vişniec. This work is based on some of the most horrible events that happened during and after the Yugoslavian wars and it narrates a global experience – on many semantic levels and utilizing hermeneutical instruments – throughout the story of a single family, making, in the process, stand out in a clearer way the rich relations between the living and the phantasmatic category of the “living-dead” that continues to communicate with the former. I’ve operated, to shed a light on those phenomena, an analysis based on some anthropological studies that take in exam the violence’s dynamics, but also, of course, I’ve used many auxiliary studies published in Italy and France, that analyze more in detail the drama in question. But the peculiarity of my study is to apply some of the anthropological aspects of war and to collocate this work in the context in which it belongs, demonstrating also how the dramatist has done some thorough research before composing the drama.
Article history: Received 15 July 2022; Revised 2 November 2022; Accepted 11 November 2022; Available online 20 December 2022; Available print 30 December 2022.
REZUMAT. Cuvântul „progres”: Există viața după moarte? Există viața după război? Scopul acestui articol este de a analiza în profunzime una dintre cele mai interesante piese ale cunoscutului dramaturg franco-român, Matei Vișniec. Demersul critic pornește de la unele dintre cele mai tragice evenimente care au avut loc în timpul războaielor balcanice din anii ’90 ai secolului trecut și oferă o interpretare completă, pe mai multe paliere de semnificație, folosind instrumente de lucru proprii mai multor direcții hermeneutice, cu privire la o experiență limită filtrată prin povestea unei familii, cu implicații bogate semantic asupra relației dintre personaje vii și o categorie fantasmatică de morți-vii, care continuă să comunice cu primele menționate. Pentru a pune în lumină aceste fenomene, am întreprins o analiză bazată pe unele studii antropologice care abordează la nivel teoretic dinamica violenței, comentând apoi în detaliu drama, după o atentă evaluare critică a unui corpus de literatură auxiliară (recenzii, studii), publicată în Italia și Franța. Originalitatea perspectivei pe care o propun constă în aplicarea unor chei de lectură și aspecte specifice antropologiei culturale, utile înțelegerii mecanismelor războiului, cu scopul de a plasa opera în contextul căruia îi aparține, documentând în același timp modul în care dramaturgul însuși a întreprins cercetări ample în vederea compunerii acestei piese.
Cuvinte-cheie: dramă, războaie balcanice, deposedare fizică, „capitalism sălbatic”
A review of the role of pollination on the yield of cocoa plant
Authors: Dani Dani , Rokhmah Dewi Nur 
Published: December 2022

AbstractYield of cocoa (Theobroma cacao L.) plant, in form of cocoa seeds, is produced through the process of sexual reproduction. Pollination plays an important role in the successful formation of cocoa fruit and seeds. In addition, number of ovules per ovary, degree of self-incompatibility, and xenia effect are also affected the final yield. Those characters are determined by genetic factors. Cocoa flowers that are not pollinated fall within 24 hours and fail to develop into fruits and seeds. Pollination intensity up to a certain level showed a significant effect on increasing the percentage of fruit formation and the number of seeds per fruit. The role of pollinating insects, especially from the Ceratopogonidae family, is very important in dispersing pollen grains, allowing the natural pollination process to be occurred.Keywords: fertilization, xenia, meta-xenia, pollinator. AbstrakHasil tanaman kakao (Theobroma cacao L.) adalah berupa biji yang dihasilkan melalui proses reproduksi seksual. Polinasi memegang peranan penting dalam keberhasilan pembentukan buah dan biji tanaman kakao. Selain itu, hasil akhir tanaman kakao juga dipengaruhi oleh karakter jumlah ovul per ovarium, tingkat inkompatibilitas sendiri, dan efek xenia. Karakter-karakter tersebut dikendalikan secara genetik. Bunga kakao yang tidak diserbuki akan gugur dalam waktu 24 jam dan gagal berkembang menjadi buah dan biji. Intensitas polinasi hingga level tertentu menunjukkan pengaruh yang nyata terhadap peningkatan persentase pembentukan buah dan jumlah biji per buah. Peran serangga penyerbuk, terutama dari famili Ceratopogonidae, sangat penting dalam menyebarkan polen sehingga proses polinasi secara alami dapat terjadi.Kata Kunci: pembuahan, xenia, meta-xenia, polinator
A prostitute as the unsung heroine in Aphra Behn’s The Rover
Authors: Jelínková Ema 
Published: December 2022

Abstract
Aphra Behn, a Restoration playwright of unprecedented success, lived by her pen and therefore was obliged to conform to the other literary production of that time (written mostly by men): comedies featuring libertines, coarse morals, debauchery and fortune-hunting protagonists. Behn wrote in this manner, yet adding a satirical spin to her work, by presenting the character of Angellica Bianca, a prostitute (actually a very ladylike companion to older wealthy men). Paradoxically, Angellica is presented as the most upright and generous person among the cast; lamentably, she believes in oaths, of which Wilmore, the double-dealing eponymous rover of the play, cures her mercilessly and swiftly, as soon as he meets a virgin, who comes with a large fortune attached. By this, Behn introduces a dark undercurrent to an ostensibly comic play. This paper pays homage to the elaborate ways Aphra Behn employed to present a prostitute as the most intriguing character of the play.
Analysing analytical minds. An interpersonal pragmatics approach to literary discourse
Authors: Miššíková Gabriela 
Published: December 2022

Abstract
Taking an interpersonal pragmatics approach, this paper aims to view literary text as social discourse where conversational exchanges convey more than the content of talk. Applying the method of interpersonal pragmatic analysis, centred around the notions of implicatures and the concept of face in pragmatics, the social status of speakers is revealed via expressing their personal desires, preferences and professional ambitions. Combining the models of pragmatic stylistics analysis and the conception of interpersonal rhetoric (Leech, 1983) enables effective exploration of the interplay between characters, their efforts to comply with the cooperative and politeness principles, following particular communicative goals in conversations, making inferences and understanding implicatures. Focusing on the above-stated aims of research, the historical thriller The Interpretation of Murder by Jed Rubenfeld (2006) was chosen as the subject of analysis. In this novel, psychoanalysis and interpretation of a patient’s/victim’s responses, the unique application of professional expertise in psychoanalysis, palpable rivalry between scholars, as well as a desire for international recognition provide rich material for analysis. The presented research contributes new insights into the scholarly debate on interpersonal pragmatics, showing that approaching literary discourse analysis via a pragmatic stylistics approach is relevant and beneficial.
Diagnosis and classification of hereditary fibrinogen disorders
Authors: Casini Alessandro 
Published: December 2022

Abstract
Hereditary fibrinogen disorders (HFDs) are rare bleeding disorders with a wide spectrum of biological and clinical features. While most patients with HFDs are at risk to suffer from mild to severe, sometimes life-threatening bleeding, thrombotic events are also common. Therefore, an appropriate diagnosis is needed to offer the optimal treatment. Diagnosis of HFDs can be challenging and plenty of pitfalls. The sensitivity and specificity of hemostasis routine test are depending on the reagents, the methods, and the fibrinogen variants. To distinguish subtypes of HFDs additional tests are often required. Historically based on the assessment of fibrinogen levels, a recent classification also considers the clinical phenotype and the genotype. In this short review, diagnosis strategies and HFDs classification are reviewed.