bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring the health benefits and functional properties of goat milk proteins
Authors: ALKaisy Qausar Hamed , Al‐Saadi Jasim S. , AL‐Rikabi Ali Khudhair Jaber , Altemimi Ammar B. , Hesarinejad Mohammad Ali , Abedelmaksoud Tarek Gamal 
Published: June 2023

AbstractGoat milk proteins are unique in their nutritional and functional properties and have become increasingly popular in recent years. A variety of methods have been studied for extracting and isolating these proteins, with coprecipitation being a particularly effective approach. Compared to cow milk proteins, goat milk proteins contain higher levels of certain amino acids such as tryptophan and cysteine, while maintaining similar nutritional properties. Additionally, they have superior functional properties, including better emulsifying and foaming properties, which make them an attractive option for developing new food products. Research has shown that goat milk proteins have several health benefits, including immunomodulatory effects, allergy management, anti‐inflammatory, and antioxidant effects, as well as antimicrobial and anticancer properties. They have the potential to be used as a treatment for autoimmune diseases, allergies, and other immune system disorders due to their ability to modulate the production of cytokines and other immune system components. Furthermore, their antimicrobial properties can help prevent the growth of harmful bacteria and reduce the risk of infection. Future research will focus on the potential of goat milk proteins as a functional food ingredient, their effects on gut health and microbiota, and their therapeutic potential for various health conditions. This research may lead to the development of new functional foods that promote health and prevent disease, and potentially pave the way for the use of goat milk proteins as a therapeutic agent for various health conditions.
Electrochemical Oxidation of Alcohols Using Halogen Mediators
Authors: Yamamoto Kosuke , Kuriyama Masami , Onomura Osamu 
Published: June 2023

AbstractThe high importance of carbonyl compounds in organic synthesis and fine chemical industries has let the development of efficient and environmentally benign methods for the oxidation of alcohols be an important research field. Electrochemistry would be one of the ideal strategies to achieve green redox processes avoiding the use of chemical oxidants/reductants. Due to the relatively high oxidation potential of alcohols, indirect methods using redox mediators have often been employed for the electrochemical alcohol oxidation. Halide salts would be one of the most traditional but still common mediators owing to the advantage of wide commercial availability and cost‐efficiency. This review summarized the electrogenerated active halogen‐mediated transformations of prim‐ sec‐, and tert‐alcohols from the pioneering works to the recent examples. In addition, recent advances in the direct oxidation of alcohols are also presented.
Effects of Dienogest on breasts of women of reproductive age and women in menopausal transition: A cohort study
Authors: Huang Kuan‐Ju , Li Ying‐Xuan , Wu Chin‐Jui , Chang Wen‐Chun , Wei Lin‐Hung , Sheu Bor‐Ching 
Published: June 2023

SynopsisDienogest appears not to have any adverse breast effects on women of reproductive age.
Prognostic and discriminatory abilities of imaging scoring systems in predicting COVID‐19 adverse outcomes
Authors: Kandil Omneya , Elgenidy Anas , Saba Patrick , Hasan Mohamed Tarek , Galbraith Kenneth , Spooner Mark , Ajao Demi , Yaipen Omar , Ayad Elyas , Nassar Abdelrahman , Hamka Khalil , Hasan Walaa , Shah Jaffer , Shawkat Ahmed , Hakim Diaa , Aiash Hani 
Published: June 2023

AbstractBackgroundTo evaluate the discriminatory ability of imaging modalities' scoring systems in the prediction of COVID‐19 adverse outcomes like ICU admission, ventilatory support, or mortality.MethodsWe searched PUBMED, EBSCO, WEB OF SCIENCE, and SCOPUS. Two authors independently screened the resulting papers for fulfillment criteria. Meta‐DiSc version 1.4, RevMan version 5.4, and MedCalc version 19.1 were used for test accuracy analysis, sensitivity and specificity analysis, and pooling Area under the curve for discriminatory assessment, respectively.ResultsRegarding mortality prediction, the computed tomography (CT) showed significantly higher sensitivity [80%; 95% CI 0.74–0.85] and positive likelihood ratio (PLR) [4.41 95% CI 2.94–6.61] relative to the Lung Ultrasound Score (LUS) approach, while the LUS approached the CT scan with specificity of 81% [95% CI 0.78–0.83] and negative likelihood ratio (NLR) of [0.32; 95% CI 0.16–0.64]. The pooled area under ROC for LUS was [AUC = 0.777, 95% CI 0.701–0.852; p < 0.001, I2 = 74.86%, p = 0.019] while the pooled area under ROC for CT severity score was [AUC = 0.855, 95% CI 0.78–0.93; p < 0.001, I2 = 93.73%, p < 0.001]. Regarding adverse outcomes prediction, the LUS had a slightly higher specificity of [78%; 95% CI 0.75–0.80] and PLR of [3.60; 95% CI 2.28–5.68] compared to CT score. The pooled AUC using LUS was (0.77, 95% CI 0.719–0.832; p < 0.001), while using CT severity score was (0.843, 95% CI 0.787–0.898; p < 0.001), and using X‐ray scores was (0.814, 95% CI 0.751–0.878; p < 0.001).ConclusionCT severity score showed a better discriminatory ability in predicting COVID‐19 adverse outcomes, as in‐hospital mortality, ICU admission, and need for ventilatory support compared to LUS and X‐RAY scores, while the LUS, being more specific, had a slightly better prognostic value.
A direct approach to Kilian–Lewis style counterfactual analysis in vector autoregression models
Authors: Chen Shiu‐Sheng 
Published: June 2023

SummaryThis paper proposes a direct approach to Kilian–Lewis style counterfactual analysis in structural vector autoregression models. The proposed approach is easy to implement, and the procedure of counterfactual construction is more transparent than the indirect approach. Practitioners conducting Kilian–Lewis style counterfactual analysis should find the proposed approach novel and useful.
Ghars date extract/iodide ions system as an eco‐friendly corrosion inhibitor for API 5L X70 steel in sulfuric acid
Authors: Bouamra Bouzid , Djellab Mounir , Bentrah Hamza , Chala Abdelouahad , Kherief Slimane , Taoui Hicham 
Published: June 2023

AbstractBackgroundGhars date fruit is very rich in polysaccharides, which qualifies it to be exploited as a green corrosion inhibitor. Ghars date is produced in large commercial quantities in Africa and Asia, which gives them the opportunity to be used as a cheap raw material for the industry of eco‐friendly inhibitors.ObjectivesThe synergy between the Ghars date extract (GDE) and iodide ions is investigated for the first time to improve the inhibition efficiency for API 5 L X70 pipeline steel in 0.5 mol L−1 sulfuric acid.MethodsThe synergistic effect of the GDE and iodide ions is studied by potentiodynamic polarization curves, electrochemical impedance spectroscopy, scanning electron microscopy and energy‐dispersive X‐ray spectroscopy.ResultsThe inhibition efficiency is 45.5% at 2 g L−1 GDE at 20°C, while it increases to 97.9% when 5 × 10−4 mol L−1 of potassium iodide is added at 25°C. The GDE/iodide ion system follows the Langmuir adsorption isotherm, involves both physical adsorption and chemical adsorption and acts as a mixed‐type inhibitor.ConclusionsIt is found that significant corrosion inhibition can be obtained in a synergistic manner between Ghars date extract and iodide ions for the API 5 L X70 pipeline steel in sulfuric acid.
Risk of burnout, psychological growth, longevity of career and making sense of Covid‐19 in senior Australian radiation oncologists
Authors: McCormack Lynne , Falcioni Dane , Lee Yoo Young 
Published: June 2023

AbstractIntroductionSenior radiation oncologists in hospital/organisational settings, are repetitively and vicariously exposed to others' traumatic distress‐perpetuating risk of burnout. Little is known of the additional organisational burdens of the Covid‐19 pandemic on their mental well‐being for career longevity.MethodsUsing Interpretative Phenomenological Analysis, semi‐structured interviews provided positive and negative subjective interpreted data from five senior Australian radiation oncologists during Covid‐19 lockdowns.ResultsOne superordinate theme, Vicarious risk, hierarchical invalidation, redefining altruistic authenticity, overarched four subordinate themes: (1) Vicarious contamination of caring, (2) The hierarchical squeeze, (3) The heavy burden of me and (4) Growth of authenticity. For these participants, juxtaposed challenges to career longevity and mental well‐being were ‘self’ as empathic carer to vulnerable patients, and ever‐increasing burdens of the organisation. Sensing invalidation, they experienced periods of exhaustion and disengagement. However, with experience and seniority, self‐care was prioritised and nurtured through intrapersonal honesty, altruism and relational connectedness with patients and mentoring forward junior colleagues. Focusing on mutual well‐being, a sense of life beyond radiation oncology became acceptable.ConclusionsFor these participants, self‐care became a relational joining with their patients separate from the lack of systemic support which heralded an early termination to their career for psychological well‐being and authenticity.
Incidence and Reimbursement Trends for Facial Fracture Repair in the Elderly: A Medicare Analysis
Authors: Torabi Sina J. , An Miranda B. , Birkenbeuel Jack L. , Lonergan Ashley R. , Salehi Parsa P. , Manes R. Peter , Azizzadeh Babak , Kuan Edward C. 
Published: June 2023

ObjectivesThe aim was to describe incidence and reimbursement trends of surgical repair of facial fractures among the Medicare population.MethodsThe annual procedure data from the Centers for Medicare and Medicaid Service National Part B Data File from 2000 to 2019 were queried.ResultsThe total number of surgically corrected facial fractures increased from 10,148 in 2000 to 19,631 in 2019 in a linear pattern (r = 0.924). Specifically, nasal bone/septum fracture repairs increased the most by 200.6% (n = 4682 to n = 14,075), whereas operations for TMJ dislocations, malar/zygoma fractures, and alveolar ridge/mandibular fractures decreased by 27.9%, 12.3%, and 3.2%, respectively, between 2000 and 2019. Correspondingly, the total Medicare reimbursement rose from $2,574,317 in 2000 to $4,129,448 in 2019 (r = 0.895). However, the mean reimbursement for all procedures decreased from $376.63 to $210.35 (44.1% fall) over the same time after adjusting for inflation, with this trend holding for individual fracture types as well.ConclusionsGiven the population's increasing age, there has been a significant increase in the number of surgical repairs of facial fractures in Medicare patients between 2000 and 2019. However, this is largely driven by an increase in nasal bone/septum closed reductions, with stagnant and, in some cases, declining incidence among other fracture repairs. The reason is unclear and may be related to an increase in nonoperative management or poor outcomes. Nevertheless, like other subfields within otolaryngology and medicine at large, payments have lagged far behind, which may play some role.Level of Evidence3 Laryngoscope, 134:659–665, 2024
Organic fertilization promotes the accumulation of soil particulate organic carbon in a 9‐year plantation experiment
Authors: Ren Tingting , Liao Jiahui , Delgado‐Baquerizo Manuel , Ni Juanping , Li Yuanyuan , Jin Long , Ruan Honghua 
Published: June 2023

AbstractManagement practices are expected to influence the capacity of forests to mitigate climate change. However, the long‐term effects of afforestation on soil carbon accumulation in response to contrasting management regimes remain poorly understood. Here, we combined organic matter fractionation with a nine‐year‐long organic fertilization experiment to investigate the influences of largely accepted practices such as biochar (BC) and biogas‐slurry (BS) inputs on the accumulation of soil particulate organic carbon (POC) and mineral‐associated organic carbon (MAOC) in three soil horizon depths (0–25, 25–50, and 50–75 cm, respectively). Our results suggested that both BS and BC significantly enhanced the POC and total soil organic carbon (SOC) content but overall did not significantly influence MAOC. Moreover, the POC and MAOC was more responsive to BS than BC. Further, our analyses revealed that the effects of BC on POC and MAOC were indirectly regulated by changes in the SOC: total nitrogen (TN) ratio, while BS influenced POC and MAOC by regulating TN. However, the responses of MAOC to the infiltration of organic fertilizers into the mineral soil should not be ignored, especially under high BC levels. Our work revealed that management practices are critical for supporting the long‐term capacity of new forests to accumulate soil carbon, thereby facilitating the provision of nature‐based solutions in response to climate change.
A significant loop of lake sedimentation state links catchment eco‐surroundings and lake biogenic regime shifts
Authors: Ran Fengwei , Nie Xiaodong , Wang Shilan , Xiao Tao , Yang Changrong , Liu Yi , Wang Lingxia , Liu Yaojun , Chu Xin , Li Zhongwu 
Published: June 2023

AbstractAs an important destination for upstream materials and element accumulation, lake sediments hold a multitude of contextual information about climatic changes and anthropogenic disturbances. However, understanding the lake sedimentation state to link catchment pressures and biogenic regime shifts remains challenging. To address this, research was conducted on the lake sedimentation state, including the dynamics, catchment drivers, effects on biogenic regimes, and responses to typical historical events using nine sediment cores from Dongting Lake, China, a typical global priority ecoregion. Three transitions of lake sedimentation state were distinguished over the century (1937, 1968, and 1993), whereby hydrologic dynamics and land‐use changes in the watershed were the direct drivers with relative contributions of 16.30% and 14.56%, respectively. Lake sedimentation state and organic matter inputs not only preceded sediment biogenic elements at the shift time but also exhibited nonlinear trigger effects on biogenic element contents (R2 = 0.47, p < 0.01), which promoted an increase in sediment biogenic element burial rates. Rate of change analysis indicated that intensive human activities altered the relationship between the sedimentation state and biogenic regime shift, thus revealing the response to anthropogenic events in the catchment. Pathways quantified by the partial least squares path model established the link between watershed attributes and lake biogenic properties via the lake sedimentation state. Our findings revealed a cascading linkage among catchment eco‐surroundings, lake sedimentation states, and biogenic regime shifts. The research further provided insights into driver‐response relationships in lake‐catchment systems.
A Ku/K‐band wideband crossed dipole circularly polarized array with low profile
Authors: Li Wenxun , Zhang Yun , He Xiaofeng , Chen Kai , Jiang Guangming , Yang Xiaoqing 
Published: June 2023

AbstractA low‐profile Ku/K band circularly polarized phased array antenna based on crossed dipole and four parasitic elements is presented. Four parasitic patches and the outline of dipole arms which are designed as an exponentially gradual curve are intended to broaden impedance bandwidth. For better integrated design, the plated through holes at the bottom of substrate replaces the metal cavity, aiming to enhance the radiation characteristics of the positive direction. The small angle sequential ro0tation tech is adopted to further increase the axial ratio (AR) bandwidth. The 8 × 8 antenna array is operated from 15.5 to 23.5 GHz (41%), with the size of 56 mm × 56 mm × 2.54 mm. In the operating frequency, the array demonstrates an average peak realized gain of 24.3 dBic and has a 3‐dB AR beamwidth with scanning angle from −60° to 60° in the plane of ɸ = 0° and ɸ = 90°.
Spectral Resolution and Speech Perception in Cochlear Implanted School‐Aged Children
Authors: Noble Anisha R. , Halverson Destinee M. , Resnick Jesse , Broncheau Mariette , Rubinstein Jay T. , Horn David L. 
Published: June 2023

AbstractObjectiveCochlear implantation of prelingually deaf infants provides auditory input sufficient to develop spoken language; however, outcomes remain variable. Inability to participate in speech perception testing limits testing device efficacy in young listeners. In postlingually implanted adults (aCI), speech perception correlates with spectral resolution an ability that relies independently on frequency resolution (FR) and spectral modulation sensitivity (SMS). The correlation of spectral resolution to speech perception is unknown in prelingually implanted children (cCI). In this study, FR and SMS were measured using a spectral ripple discrimination (SRD) task and were correlated with vowel and consonant identification. It was hypothesized that prelingually deaf cCI would show immature SMS relative to postlingually deaf aCI and that FR would correlate with speech identification.Study DesignCross‐sectional study.SettingIn‐person, booth testing.MethodsSRD was used to determine the highest spectral ripple density perceived at various modulation depths. FR and SMS were derived from spectral modulation transfer functions. Vowel and consonant identification was measured; SRD performance and speech identification were analyzed for correlation.ResultsFifteen prelingually implanted cCI and 13 postlingually implanted aCI were included. FR and SMS were similar between cCI and aCI. Better FR was associated with better speech identification for most measures.ConclusionPrelingually implanted cCI demonstrated adult‐like FR and SMS; additionally, FR correlated with speech identification. FR may be a measure of CI efficacy in young listeners.
Effect of Yokukansan on preoperative anxiety and postoperative pain in mandibular third molar extraction: A pilot study
Authors: Yoshida Kensuke , Kodama Yasumitsu , Kiyomi Anna , Pak Kyongsun , Nagai Takahiro , Saito Chie , Yamazaki Kyosuke , Sugiura Munetoshi , Toyama Akira , Tomihara Kei 
Published: June 2023

AbstractObjectivesManaging perioperative anxiety improves postoperative recovery significantly by reducing postoperative pain. However, little is known about association between preoperative anxiety and postoperative pain in oral surgical procedures. In the present study, we examined the effect between preoperative anxiety and postoperative pain in mandibular third molar extraction and the anxiolytic effect of Yokukansan (YKS) during the perioperative period.Materials and methodsWe conducted a prospective cohort study from September 2021 to May 2022. For patients with a complaint of insomnia on the day before surgery, 2.5 g per package of YKS was administered before sleep on the day before surgery. Twelve patients were administered YKS, and 23 patients were not (non‐YKS).ResultsPerioperative anxiety was assessed by the Hospital Anxiety and Depression Scale (HADS) and amylase in saliva, and perioperative pain was assessed by the Numerical Rating Scale (NRS) and the total number of times pain medication. There were no significant differences in HADS and amylase in saliva between the YKS and non‐YKS. The median postoperative NRS was 5 for YKS and 7 for non‐YKS. The maximum use of pain medication was 16 in YKS and 24 in non‐YKS. Although no significant difference was observed in the anxiolytic effects and the improvement of postoperative pain during the perioperative period of mandibular third molar extraction between patients who took YKS and those who did not, NRS and the maximum use of pain medication were less in the YKS patients.ConclusionsTherefore, YKS may be useful for managing postoperative pain through the preoperative anxiolytic effect in oral surgical procedures.
Urinary collagen peptides: Source of markers for bone metabolic processes in kidney transplant recipients
Authors: Marx David , Anglicheau Dany , Caillard Sophie , Moulin Bruno , Kochman Audrey , Mischak Harald , Latosinska Agnieszka , Bienaimé Frank , Prié Dominique , Marquet Pierre , Perrin Peggy , Gwinner Wilfried , Metzger Jochen 
Published: June 2023

AbstractIntroduction: Kidney transplant recipients (KTRs) are at an increased risk of fractures. Total urinary hydroxyproline excretion served as marker for bone resorption (BR) but was replaced by β‐CrossLaps (CTX), a C‐terminal collagen α‐1(I) chain (COL1A1) telopeptide. We investigated the low‐molecular‐weight urinary proteome for peptides associated with changes in bone metabolism after kidney transplantation. Methods: Clinical and laboratory data including serum levels of CTX in 96 KTR from two nephrology centers were correlated with signal intensities of urinary peptides identified by capillary electrophoresis mass spectrometry. Results: Eighty‐two urinary peptides were significantly correlated with serum CTX levels. COL1A1 was the predominant peptide source. Oral bisphosphonates were administered for decreased bone density in an independent group of 11 KTR and their effect was evaluated on the aforementioned peptides. Study of the peptides cleavage sites revealed a signature of Cathepsin K and MMP9. Seventeen of these peptides were significantly associated with bisphosphonate treatment, all showing a marked reduction in their excretion levels compared to baseline. Discussion: This study provides strong evidence for the presence of collagen peptides in the urine of KTR that are associated with BR and that are sensitive to bisphosphonate treatment. Their assessment might become a valuable tool to monitor bone status in KTR.
Statistical problem‐solving teams: A case study in a global manufacturing organization in the automotive industry
Authors: Barsalou Matthew , Perkin Robert 
Published: June 2023

AbstractOrganizations are confronted with quality failures that must be addressed. Often, statistical methods can be helpful, but the organization lacks an internal statistician. This paper explores the use of a statistical problem‐solving team using Six Sigma professionals as problem‐solving team leaders, trainers, and coaches. A case study methodology is used. The actions and events from the implementation of a statistical problem‐solving team in a global manufacturing organization in the automotive industry through the first decade after implementation are described. Statistical problem‐solving bridges the gap between engineer and statistician using engineers trained to awareness‐level knowledge of statistics and supported by Six Sigma Master Black Belts. The statistical problem‐solving team members need to be highly trained in the three pillars of statistical problem‐solving: Key statistical concepts, key statistical analysis, and the key test method as well as a solid foundation in quality tools. This paper provides a unique view of a global problem‐solving team using both Six Sigma tools and methods and the 8D process as a problem‐solving methodology.
How do leveraged buyouts affect industry peers? Analysis of the information and the competition channels
Authors: Kathan Manuel C. , Tykvová Tereza 
Published: June 2023

AbstractOur paper provides a contribution to the literature on peer effects in leveraged buyouts and delivers an explanation for the seemingly contradicting findings in the existing literature. We find that the average peer announcement CAR amounts to −1.98%. A buyout may reveal private information about peer value and can also change in the competition within the buyout target industry. Our identification strategy to examine the information and competition channels relies on two quasi‐natural experiments, which generate exogenous variation in the information and competition environments. In addition, we analyze various mechanisms within these two channels by considering the cross‐section of peer CARs and by running additional tests. Our results support the revaluation and the competitive pressure hypotheses.