bluuebunny/crossref_metadata_2025_split huggingface dataset:
Management of Clinically Node‐Negative Salivary Gland Cancer: Observation, Neck Dissection, or Neck Irradiation?
Authors: Ilori Evelyn O. , Woody Neil M. , Hair Bryan B. , Rybicki Lisa , Lamarre Eric D. , Ku Jamie Ahn , Prendes Brandon , Scharpf Joseph , Burkey Brian B. , Koyfman Shlomo A. , Campbell Shauna R. 
Published: January 2025

ABSTRACTIntroductionSalivary gland malignancies are heterogeneous tumors with highly variable outcomes. Elective neck management options include observation, neck dissection (ND), and neck irradiation (NI). We sought to compare outcomes of cN0 salivary gland cancer by elective neck management.MethodsAn IRB‐approved registry was queried for cN0 salivary gland cancers and categorized based on neck management into observation, ND, NI, and ND + NI groups. cN0 included no evidence of clinical or radiographic metastatic lymphadenopathy.ResultsA total of 445 patients were included with 203 in observation, 83 ND, 71 NI, and 88 ND + NI. Median follow‐up was 60.8 months (range 0.4–258). There were 47% clinical T1 tumors, 29% T2, and 12% of each T3 and T4. Exactly 90% were cN0 and 10% with borderline lymph node(s). The major salivary gland was the most common site (74%) and the most common histologies included 28% mucoepidermoid and 20% adenoid cystic. Risk factors associated with regional recurrence include age, borderline lymph node features, pathologic T and N stage, poorly differentiated, positive margin, lymphovascular space invasion, and extranodal extension (all p < 0.05). There was no significant difference in local (9.9%–16.7%, p = 0.6) or regional (3.9%–9.4%, p = 0.76) recurrence between all four groups. Five‐year distant recurrence was significantly different at 7% for observation, 16% in ND, 25% in NI, and 37% in ND + NI (p < 0.001). Ten‐year OS estimates were 78% for observation, 66% for ND, 69% for NI, and 52% in ND + NI (p < 0.001).ConclusionFor patients with cN0 salivary gland cancer, ND and NI yield similar regional control in appropriately selected patients. In high‐risk patients with several adverse risk features ND + NI results in favorable regional control but distant metastasis is a driving factor affecting overall survival.
Comparing PD‐L1 and PD‐1 inhibitors plus bevacizumab combined with hepatic arterial interventional therapies in unresetable hepatocellular carcinoma: A single‐center, real‐world study
Authors: He Minrui , Xie Wa , Yuan Ze , Chen Jinbin , Wang Juncheng , Fu Yizhen , Hu Zili , Meng Qi , Gao Wenqing , Hu Dandan , Zhang Yaojun , Pan Yangxun , Zhou Zhongguo 
Published: January 2025

AbstractWith the rise of anti‐vascular endothelial growth factor antibody and programmed cell death‐ligand 1 (PD‐L1) regimens, particularly bevacizumab and atezolizumab, as first‐line treatments for advanced hepatocellular carcinoma (HCC), there is a need to explore PD‐L1 and programmed cell death 1 inhibitors in combination therapies for unresectable HCC (uHCC). Integrating systemic therapies with locoregional approaches is also emerging as a potent strategy. This study compares the outcomes of atezolizumab (PD‐L1 inhibitor) and sintilimab (programmed cell death 1 inhibitor) with bevacizumab or its biosimilar, combined with hepatic arterial interventional therapies (HAIT) in uHCC patients. From January 2020 to September 2023, a retrospective analysis was conducted on 138 uHCC patients at Sun Yat‐sen University Cancer Center. The cohort included 69 patients treated with atezolizumab with bevacizumab (Bev/Ate) and 69 with bevacizumab biosimilar with sintilimab (Bio/Sin), combined with HAIT. The propensity score matching was also employed to further explore the efficacy and safety. The median progression‐free survival (mPFS) was 13.8 months for the Bev/Ate group and 10.0 months for the Bio/Sin group (p = 0.188). The Bev/Ate group showed significantly longer intrahepatic mPFS (HR 0.381; 95% confidence interval 0.176–0.824; p = .018) and higher overall response rates compared with the Bio/Sin group (60.87% vs. 31.88%, p = .001; 69.57% vs. 49.28%, p = .024) based on Response Evaluation Criteria in Solid Tumors v1.1 and modified Response Evaluation Criteria in Solid Tumors criteria. Treatment‐related adverse events were similar between groups (p > .050). Combining atezolizumab or sintilimab with bevacizumab or its biosimilar alongside HAIT provided similar overall PFS in uHCC patients. However, the atezolizumab‐bevacizumab combination with HAIT showed superior intrahepatic PFS and control rates, warranting further validation.
Digitalisation and Firm‐Level ESG Performance and Disclosures: A Scientometric Review and Research Agenda
Authors: Singhania Monica , Bhan Ibna , Seth Surabhi 
Published: January 2025

ABSTRACTDigitalisation and sustainability are not just critical business notions; they are also interdependent drivers of future business success. By employing digital tools, firms can improve their environmental, social, and governance (ESG) performance, increase transparency, and maintain stakeholders' accountability. This increasing significance has elevated the value of examining the impact of digitalisation on firm‐level ESG performance and disclosures. This study explores this relationship by synthesising 199 relevant research records published during 2019–2024, obtained from Web of Science and Scopus, using a bibliometric and systematic literature review approach. Our descriptive analysis reveals exponential growth in publications on this relationship during the study period, focusing predominantly on quantitative research leveraging secondary data. Regression analysis emerged as the most popular analytical technique, followed by structural equation modelling. The theoretical foundations of this research are based on the resource‐based view and dynamic capabilities view. The Co‐occurrence analysis identifies China, Italy, and England as the leading contributors, with research hot spots centring around concepts such as ‘Industry 4.0’, ‘sustainability performance’, ‘sustainable development’, and ‘sustainability reporting’. Co‐citation analysis highlights the leading journals, authors, and documents, emphasising the scholarly foundations of this field. Further, thematic analysis uncovers the benefits of digitalisation across four dominant dimensions: sustainability performance, supply chain sustainability, sustainability assessment, and sustainability accounting and reporting. Finally, we discuss critical knowledge gaps and propose future research questions to advance understanding of this emerging field.
Sexual Minority Stress: Preliminary Evidence of Accelerated Pubertal Development in Early Adolescence
Authors: Papke Victoria , Wiglesworth Andrea , Carosella Katherine A. , Başgöze Zeynep , Green Aurora E. , Fiecas Mark , Cullen Kathryn R. , Klimes‐Dougan Bonnie 
Published: January 2025

ABSTRACTIntroductionSocietal stressors place a tremendous burden on individuals who identify with a sexual minority identity. While minority stress experienced by racial/ethnic minority groups has been linked to accelerated aging, this link has yet to be examined among sexual minority youth. This study explores whether sexual minority youth who indicate experiencing stress at home or school (Minority Stress) due to their identity show evidence of accelerated aging (pubertal status or tempo) compared to those who do not report such experiences (No Minority Stress).MethodsData are from the Adolescent Brain Cognitive Development (ABCD) Study. Participants were approximately 9–10 years old at baseline, 10–11 years old at Time 1, and 11–12 years old at Time 2. Measures included child‐reports of sexual minority identity and stressors, and parent‐reports of adolescent pubertal development.ResultsAmong 432 included participants who identified with a sexual minority identity, 83.6% were assigned female at birth and 24.8% were in the Minority Stress group. There were consistent results showing that sexual minority youth in the Minority Stress group showed accelerated pubertal status over time compared to those in the No Minority Stress group. Pubertal tempo (i.e., slope) was only accelerated for those who first identified as sexual minority at Time 2.ConclusionOur findings underscore that minority stress experienced by sexual minority youth may be linked to differences in pubertal development among these youth. The developmental and clinical implications of these patterns present critical lines for future research concerned with the wellbeing of sexual minority youth.
The Role of Proton Magnetic Resonance Spectroscopy in Neonatal and Fetal Brain Research
Authors: Hui Steve C.N. , Andescavage Nickie , Limperopoulos Catherine 
Published: January 2025

The biochemical composition and structure of the brain are in a rapid change during the exuberant stage of fetal and neonatal development. 1H‐MRS is a noninvasive tool that can evaluate brain metabolites in healthy fetuses and infants as well as those with neurological diseases. This review aims to provide readers with an understanding of 1) the basic principles and technical considerations relevant to 1H‐MRS in the fetal‐neonatal brain and 2) the role of 1H‐MRS in early fetal‐neonatal development brain research. We performed a PubMed search to identify original studies using 1H‐MRS in neonates and fetuses to establish the clinical applications of 1H‐MRS. The eligible studies for this review included original research with 1H‐MRS applications to the fetal‐neonatal brain in healthy and high‐risk conditions. We ran our search between 2000 and 2023, then added in several high‐impact landmark publications from the 1990s. A total of 366 results appeared. After, we excluded original studies that did not include fetuses or neonates, non‐proton MRS and non‐neurological studies. Eventually, 110 studies were included in this literature review. Overall, the function of 1H‐MRS in healthy fetal‐neonatal brain studies focuses on measuring the change of metabolite concentrations during neurodevelopment and the physical properties of the metabolites such as T1/T2 relaxation times. For high‐risk neonates, studies in very low birth weight preterm infants and full‐term neonates with hypoxic–ischemic encephalopathy, along with examining the associations between brain biochemistry and cognitive neurodevelopment are most common. Additional high‐risk conditions included infants with congenital heart disease or metabolic diseases, as well as fetuses of pregnant women with hypertensive disorders were of specific interest to researchers using 1H‐MRS.Evidence Level1Technical EfficacyStage 2
Comparison of LEIS, SIMS, and AR‐XPS as Methods for Surface Characterization of Passivated Zn–Al–Mg Steel
Authors: Ponomareva Maria , Duchoslav Jiri , Stifter David , Kogler Matthias , Fahrnberger Florian , Hutter Herbert , Luckeneder Gerald , Hader‐Kregl Laura , Valtiner Markus 
Published: January 2025

ABSTRACTThe combination of different surface‐sensitive techniques is frequently used in material sciences to analyze complex systems. How these methods compare in terms of quantitative and qualitative information is often unclear. In this study, we directly compare low‐energy ion scattering spectroscopy (LEIS), secondary ion mass spectrometry (SIMS), and angle‐resolved X‐ray photoelectron spectroscopy (AR‐XPS) depth profiling analyses. Therefore, we use the Zn–Al–Mg model coatings after alkaline and acidic treatments in model solutions. The combined use of AR‐XPS and LEIS depth profiling proved effective in studying compositional and elemental changes in the surface oxides of Zn–Al–Mg coatings after alkaline and acidic treatments. Additionally, by combining these methods, SIMS depth profiling can be effectively calibrated for matrix effects. Here, we find that, for example, Mg is considerably more sensitive to SIMS detection, based on effective secondary ionisation. Such effects must be considered for data interpretation.
How Second Screens Shape Consumer Experiences: The Role of Social Connection on Repeat Viewing
Authors: Wu Will Wei , Powell Emily R. , Barasch Alixandra 
Published: January 2025

ABSTRACTThe use of additional electronic devices, such as smartphones or tablets, for sharing, reviewing, and communicating online has become an integral part of consumers' media consumption experiences. Previous research has demonstrated that using connected devices during consumption experiences mainly serves to decrease the utility consumers derive from their experiences. In contrast, the present research examines when second screen use might have a positive effect on the media consumption experience. Across three studies using a variety of real‐world media consumption experiences, we demonstrate that second screen use enhances consumers' feelings of social connection, which in turn increases their likelihood of repeating the media consumption experience. We also identify the viewing context as a theory‐driven and practically‐relevant moderator: second screen use enhances feelings of social connection and repeat viewing when viewers are watching alone, but this effect reverses when viewers are watching with others. These findings have clear substantive implications for a variety of industry stakeholders, including broadcasters, content creators, and platform developers who wish to capture greater consumer attention and foster long‐term viewer loyalty.
LINC01305 and LAD1 Co‐Regulate CTTN and N‐WASP Phosphorylation, Mediating Cytoskeletal Reorganization to Promote ESCC Metastasis
Authors: Yang Hang , Xiong Rong , Zhang Ruolan , Sun Shan , Pan Yingjie , Zhao Quanneng , Bie Jun , Luo Yi , Song Guiqin , Liu Kang 
Published: January 2025

ABSTRACTEsophageal squamous cell carcinoma (ESCC) is prone to metastasis and is a leading cause of mortality. The cytoskeleton is closely related to cell morphology and movement; however, little research has been conducted on ESCC metastasis. In this study, we found that the anchoring filament protein ladinin 1 (LAD1) specifically binds to LINC01305 for co‐regulating the level of modulating cortactin proteins (CTTN) and neuronal Wiskott–Aldrich syndrome protein (N‐WASP) phosphorylation, which mediates cytoskeletal reorganization and affects the metastasis of ESCC cells. Additionally, LINC01305 and LAD1 jointly promoted the epithelial–mesenchymal transition (EMT) process by activating the phosphoinositide‐3‐kinase–protein kinase B (PI3K/AKT) signaling pathway. Moreover, LINC01305 and LAD1 were related to the late clinical stage and lymph node metastasis of ESCC. Our study demonstrated that LINC01305 and LAD1 are major determinants of ESCC dissemination and revealed a novel molecular mechanism of cytoskeletal reorganization that controls ESCC metastasis.Trial Registration: N/A.
Simulation and experiment investigation on leakage rate of composite materials with the consideration of curing defects
Authors: Liu Shu , Zhan Lihua , Ma Bolin , Zhang Dechao , Yao Shunming , Chen Weitao , Du Chuan 
Published: January 2025

AbstractThis study investigates the influence of curing defects on the leakage behavior of CFRP. A macroscopic homogeneous leakage model incorporating curing defects was developed to account for their impact on leakage. By combining simulation and experimental methods, the relationship between curing defects and leakage rates was analyzed. The results indicate a positive correlation between leakage rate and porosity. Furthermore, the leakage rate is also influenced by the void spacing, where an initial increase in spacing leads to a rise in leakage rate, followed by a stabilization at later stages. In addition, the leakage rate shows a negative correlation with both the distance between voids and the high‐pressure side, as well as the aspect ratio of the voids. Based on these findings, a defect morphology with enhanced leak resistance is proposed.Highlights
A leakage simulation model for CFRP with void defects has been established.
The mechanisms were investigated through simulation and experimentation.
Revealed the influence of CFRP pore distribution and morphology on leakage rate.
The void characteristics of CFRP with high leakage resistance were obtained.
Experimental evaluation of residual tensile properties of CFRP‐aluminum butt adhesive joints subjected to systematic creep damage
Authors: Saeidi Googarchin Hamed , Bidadi Jamal 
Published: January 2025

AbstractThis study investigates the creep behavior and static mechanical response after creep of CFRP‐Aluminum adhesive joints subjected to sustained tensile loads. Initially, quasi‐static tensile tests were performed to determine the instantaneous static load (). Subsequently, creep tests were conducted at seven sustained load levels (i.e., 80%, 70%, 60%, 50%, 40%, 30%, and 20% of ) for durations ranging from 12 to 72 h. The main aim was to assess how creep affects the residual static mechanical properties of joints. Analysis of the creep curves revealed that the tested joints tolerated only 20%–50% of the creep load for the maximum specified creep duration (i.e., 72 h). Premature joint failure was observed under creep loads exceeding 50% of before reaching the maximum designated creep duration. Following this, tensile after creep (TAC) tests were performed on the creep‐loaded joints (i.e., those subjected to 20%–50% of ) at a crosshead speed of 0.5 mm/min. These tests aimed to determine the variations in the joint's residual mechanical properties. The TAC results indicated that the tensile stresses were primarily tolerated by the adhesive, with no significant delamination observed in the CFRP substrate. Notably, considerable reductions in residual properties (both strength and strain) were noted for longer creep durations, which were attributed to adhesive degradation. Conversely, reductions were minimal for shorter creep durations. Finally, semi‐empirical models were developed to predict the residual tensile properties of the joints for use in numerical simulations of creep behavior in future research.Highlights
Examining creep and post‐creep tensile behavior in hybrid adhesive joints.
Increased joint creep strain with higher creep load levels.
Reduction in joint residual strength post‐creep.
Creep causes reduced flexibility in the joint.
Construction and phase transition characteristics of nano‐graphite‐induced rapid growth self‐generated proppants
Authors: Xu Min , Yin Jinrong , Li Zhenyong , Jiang Yangqi , Bismark Opoku , Fu Xiaoji , Song Yu , Ren Xianyan , Zhong Yuwang 
Published: January 2025

AbstractTo solve the problem that the self‐generated proppant in fractures grows slowly and cannot support the fractures in time, nano‐graphite (NG) was introduced into a phase change liquid (PCL) composed of “styrene‐divinylbenzene (SDB)” and the resulting self‐generated proppants were constructed with a high growth speed. The NG/PCL started the phase transition from liquid to solid after 8 min at about 55°C in the wellbore section, and the phase transition was completed for only 2.5 min at a constant temperature of 65°C in fracture. Moreover, due to the high thermal conductivity and heterogeneous nucleation of the NG powder, the maximum strength of self‐generated proppant in the NG‐containing system can reach about 56.2 N during its growth process, which is 34.4% higher than that of pure SDB. The yield of the well‐dispersed spherical self‐generated proppants NG/SDB under the completely static condition can reach about 80%, of which the proppants with a particle size of 0.4 ~ 0.7 mm account for about 80%. NG/SDB exhibited an ultra‐low apparent density of approximately 1.004 g/cm3, high compressive strength, and a crushing ratio of less than 1% at a closure pressure of 52 MPa, which is lower than that of commercial quartz sand and ceramsite proppants.Highlights
Self‐generated proppants with rapid growth were developed by the introduction of NG.
Positive effects of NG in PCL system are obvious on phase transition and growth.
NG/SDB is qualified in phase transition timing and compressive strength.
The single‐microsphere yield of NG/SDB is about 80%.
The crushing ratio of NG/SDB as low as 3.92% at a closure pressure of 69 MPa.
Effects of poly(propylene carbonate) on poly(butylene adipate‐co‐terephthalate) microcellular foams: Improved expansion and reduced shrinkage
Authors: Yan Hai‐kuo , Sheng Hao‐nan , Hua Huang‐wei , Zhang Li , Yao Yu‐yuan , Bao Jin‐biao 
Published: January 2025

AbstractMicrocellular foams made from poly (butylene adipate‐co‐terephthalate) (PBAT) using supercritical carbon dioxide (scCO2) as a physical foaming agent have exhibited high shrinkage and low expansion ratios, limiting their potential applications. Previous studies have indicated that while PBAT exhibits foaming capabilities, its maximum expansion ratio typically does not exceed 20, and it is characterized by a high shrinkage ratio, which limits its application in high‐performance foams. In contrast, this study presented an 80PBAT/20PPC microcellular foam that has achieved a stable expansion ratio of 38.9 and a substantial reduction in shrinkage ratio to 9.4% from the 89.5% observed in pure PBAT. This advancement is attributed to the blending of PBAT with poly(propylene carbonate) (PPC), a polymer with moderate compatibility. PPC was uniformly dispersed within the PBAT matrix in micro/nano particle form, which inhibited crystallization and leveraged its unique molecular structure to enhance CO2 solubility, thereby increasing the expansion ratio and refining the cell structure. Additionally, PPC particles acted as stress concentrators, promoting cell wall rupture and forming an open‐cell structure. Furthermore, the higher glass transition temperature (Tg) of PPC further enhanced the stiffness of the cell walls. These synergistic effects enabled PBAT/PPC microcellular foams to effectively resist shrinkage caused by internal–external pressure differentials.Highlights
Blending with PPC increased the expansion ratio of PBAT foams to 38.9.
Shrinkage of 80PBAT/20PPC foams is drastically reduced to 9.4%.
PPC in PBAT matrix enhanced CO₂ solubility and inhibited crystallization.
PPC particles acted as stress concentrators, facilitating open‐cell structure.
Differences in Labour Mobility Between Immigrant Generations: Evidence From the European Debt Crisis
Authors: Braun Marius , Görts Jarom 
Published: January 2025

ABSTRACTImmigrants' higher responsiveness to regional differences in labour market conditions has been recognised as a potentially important adjustment mechanism to labour market shocks. This paper investigates an aspect less explored by previous research, namely how labour mobility patterns are passed on across immigrant generations. Using Euro Area household‐level data, we compare mobility patterns of first‐ and 1.5‐generation immigrants and natives. We observe that 1.5‐generation immigrants have a significantly lower interregional and international mobility compared to first‐generation immigrants but are more mobile than natives. Our results suggest that not only first‐generation immigrants but also their descendants contribute to labour market flexibility.