bluuebunny/crossref_metadata_2025_split huggingface dataset:
Karakteristik Organoleptik Produk RUTF (Ready To Use Therapeutic Food) Berbentuk Bar untuk Mengatasi Masalah Malnutrisi Akut Berat pada Balita
Authors: Novia Reni 
Published: May 2023

RUTF (Ready to Use Therapeutic Food) merupakan salah satu makanan terapetik yang dianjurkan oleh WHO untuk mengatasi masalah malnutrisi akut berat pada balita. Pengambangan produk RUTF perlu mempertimbangkan karakteristik organoleptik. Oleh karena itu, penelitian ini bertujuan untuk mengetahui karakteristik organoleptik dari produk RUTF berbentuk bar untuk mengatasi balita malnutrisi akut berat Rancangan penelitian yaitu eksperimental studi menggunakan Rancangan Acak Lengkap Faktorial (RALF) 2 kali ulangan. Pada penelitian ini sudah dikembangkan terlebih dahulu produk RUTF berbentuk bar yang meliputi 2 faktor perlakuan yaitu kombinasi penggunaan tepung kacang hijau dengan serealia (A) dan penggunaan jenis minyak nabati (B). Jenis organoleptik yang dilakukan yaitu uji rangking dan uji mutu hedonik. Hasil uji rangking menunjukkan tidak ada perbedaan yang nyata terhadap formula yang dibuat dan panelis menyukai semua formula yang diberikan. Hasil uji mutu hedonik produk RUTF berbentuk bar yang dikembangkan sudah memenuhi anjuran USDA (2012) dan UNICEF (2019) yaitu memiliki tekstur kompak, halus, mudah hancur saat ditekan, mudah untuk ditelan, memiliki warna yang menarik dan cerah, tidak memiliki aroma langu, rasa cendrung manis dan tidak pahit.
ANALISIS STRATEGI PEMASARAN PERUSAHAAN MODAL VENTURA DI TENGAH PANDEMI COVID-19(Studi Kasus Pada PT.Sarana Lampung Ventura)
Authors: Defrizal Defrizal , Nasution Elvira 
Published: May 2023

Abstract This study aims to determine the marketing strategy of venture capital companies, to remain able to print company profits and to find out the factors that can hinder the implementation of marketing strategies in the midst of the COVID-19 Pandemic. This type of research is qualitative research. the source of data in this study is the result of interviews at PT. Sarana Lampung Ventura. Data collection methods used are preliminary surveys, interviews and documentation. The result of this research is PT. SLV changes its marketing strategy. PT. SLV cooperates with Third Parties, binds cooperation agreements, conducts marketing to prospective business partners with the category of MSMEs that have potential, conducts marketing to prospective business partners remotely.
Pengaruh Viral Marketing Melalui Aplikasi Instagram Terhadap Keputusan Pembelian
Authors: Rahayu Sinta Rahayu , Mak’ibah Sinta , Sanjaya Vicky F , Metri Prima Rini 
Published: May 2023

AbstractThis study aims to examine the effect of viral marketing through the Instagram application on purchasing decisions. A case study from this research is a student of Islamic business management at UIN Raden Intan Lampung Class of 2019. This research is a quantitative research. The method used in this research is a questionnaire. The sample of this study amounted to 36 respondents. Statistical tests were carried out using PLS-based Structurel Equation Modeling. The validity test uses the factor loading value, while the reliability test uses Cronbach's alpha, Composite Reliability and Avarage Variance Extracted (AVE) values. From the proposed hypothesis, it has a positive but not significant effect. The conclusion of this study is that viral marketing has a positive but not significant effect on purchasing decisions. Keywords: viral marketing, purchasing decisions
Analisis Strategi Pemasaran Dalam Meningkatkan Volume Penjualan Kopi Susu Baper Di Masa Pandemi Covid-19
Authors: Habibuhrahman Habibuhrahman , Veronica Veronica , S Herry Gunawan 
Published: May 2023

AbstractThe coffee industry in Indonesia is growing very quickly due to the increasing demand for coffee and can create many coffee shop business opportunities in Indonesia. The increase in coffee shops in Indonesia continues to increase, one of which is in the province of Lampung, namely the Baper Milk Coffee Shop in Metro City, Lampung. The purpose of this research is to find out the marketing strategy carried out by the owner of the Baper Milk Coffee Shop in Metro City during the Covid-19 pandemic. The measuring instrument used in this research is observation, interviews and questionnaires as well as using SWOT analysis. Based on the results of the SWOT analysis, the total calculation of IFAS is 3.60 and EFAS is 3.62. From the results of the SWOT Cartesian diagram, it is known that Kedai Kopi Susu Baper in Metro City is in quadrant I, namely aggressive growth (Growth Oriented Strategy), where this situation is quite profitable, namely growth. And 11 alternative marketing strategies have been formulated that can be used by Kedai Kopi Susu Baper. Keywords: COVID-19, Marketing Strategy, SWOT Analysis
Involuntary admissions to the emergency department: a retrospective observational study
Authors: Beysard Nicolas , Jaquerod Xavier , Morandi Stéphane , Gasser Jacques , Carron Pierre-Nicolas 
Published: May 2023

AIMS: The main objective of this study was to describe patients who were involuntarily admitted to the emergency department of Lausanne University Hospital on involuntary admission in 2018 in terms of age, gender, emergency department length of stay, the motive for involuntary admission, use of psychoactive substances, diagnosis, and destination at emergency department discharge, with or without discontinuation of involuntary admission.
METHODS: This retrospective, observational, and monocentric study included patients 18 years and older admitted to the emergency department of Lausanne University Hospital on involuntary admission from January 1, 2018, to December 31, 2018. Patients were identified by the Cantonal Medical Office of Vaud. The emergency department length of stay and patient destination on discharge from the emergency department were extracted from the patient flow database, and discharge letters and involuntary admission were extracted from the electronic archiving software. Descriptive statistics were processed by using means and standard deviations for quantitative variables with a normal distribution and median and interquartile range for non-normally distributed data.
RESULTS: During the study period, 83 patients were admitted on involuntary admission to the emergency department. The majority of the patients were male (58%) with a mean age of 55 (±20) years. The median emergency department length of stay of patients with an involuntary admission was between 9 and 16 hours, depending on whether the involuntary admission was confirmed or discontinued after patient assessment in the emergency department. In comparison, the median emergency department length of stay was 6 hours for patients overall. The two principal diagnoses described were psychiatric (schizophrenia) and mental and behavioural disorders due to psychoactive substance use. Half of the patients on involuntary admission consumed psychoactive substances, primarily alcohol, and had a mean ethanolaemia of 53 (±32) mmol/l.
CONCLUSIONS:Only a third of patients admitted on involuntary admission saw this measure confirmed after their assessment in the emergency department. Involuntary admissions with admission to the emergency department is used to force patients to be examined by an emergency physician or even a psychiatrist. On-call and primary care physicians seemed to lack the time or resources to set up alternatives to emergency department admissions on involuntary admission, especially in situations in which the involuntary admission was discontinued after an emergency department assessment. This demonstrates the inappropriate use of this measure because a patient cannot be involuntarily hospitalised in an emergency department.
Rapid antimicrobial susceptibility testing in patients with bacteraemia due to Enterobacterales: an implementation study
Authors: Reiber Claudine , Bodendoerfer Elias , Brugger Silvio D. , Eberhard Nadia , Hitz Eva , Hofmaenner Daniel A. , Herren Sebastian , Kolesnik-Goldmann Natalia , Manicini Stefano , Zbinden Reinhard , Zinkernagel Annelies S. , Hasse Barbara 
Published: May 2023

AIMS OF THE STUDY: The goal of this descriptive study was to assess the performance as well as the extent of the clinical impact of rapid automated antimicrobial susceptibility testing in patients with bacteraemia due to Enterobacterales. We also aimed to analyse how rapid automated antimicrobial susceptibility testing influences clinical decision-making.
METHODS: This single-centre study conducted at the University Hospital of Zurich included data from all consecutive patients with Enterobacterales bacteraemia from November 2019 to October 2020. There was no control group. The primary outcome was the effect of rapid automated antimicrobial susceptibility testing on antibiotic therapy (no adjustment, escalation to a broader-spectrum antibiotic or de-escalation to a narrower-spectrum antibiotic). Rapid automated antimicrobial susceptibility testing results were further compared to susceptibility tests using European Committee on Antimicrobial Susceptibility Testing (EUCAST) standard methods and erroneous results were noted. Additionally, we investigated turnaround times for rapid automated antimicrobial susceptibility testing and routine diagnostic testing.
RESULTS: We analysed 106 patients with 116 episodes of bacteraemia due to Enterobacterales, with Escherichia coli and Klebsiella pneumoniae being the most frequent isolates. Almost 8% of pathogens were multidrug resistant. Rapid automated antimicrobial susceptibility testing showed category agreement in 98.4% of all interpretable cases. A significant reduction of more than 20 h in turnaround times could be achieved with rapid automated antimicrobial susceptibility testing compared to the routine diagnostic workflow. In the majority of cases, rapid automated antimicrobial susceptibility testing had no effect, given that the empirical therapy was already correct or circumstances did not allow for de-escalation. In 38.8% of cases, antimicrobial therapy was adjusted, whereas eight cases were de-escalated based on rapid automated antimicrobial susceptibility testing alone.
CONCLUSIONS: Rapid automated antimicrobial susceptibility testing may be a valuable and safe way to accelerate diagnosis. In particular, time to suitable therapy can be shortened in cases of incorrect therapy. However, physicians are reluctant to de-escalate antibiotic therapy based on rapid automated antimicrobial susceptibility testing alone, limiting its impact in everyday clinics. To further explore the potential of rapid automated antimicrobial susceptibility testing, a stringent/compulsory antibiotic stewardship programme would be a valuable next step.
Modified Jackknife Ridge Estimator for Beta Regression Model With Application to Chemical Data
Authors: Algamal Zakariya Yahya , Abonazel Mohamed R. , Lukman Adewale F. 
Published: May 2023

The linear regression model is not applicable when the response variable's value comes in percentages, proportions, and rates, which are restricted to the interval (0, 1). In this situation, we applied the beta regression model (BRM) popularly used to model chemical, environmental and biological data. The parameters in the model are often estimated using the conventional method of maximum likelihood. However, this estimator is unreliable and inefficient when the explanatory variables are linearly correlated- a condition known as multicollinearity. Thus, we developed the Jackknife Beta ridge and the modified Jackknife Beta ridge estimator to estimate the regression coefficient when multicollinearity exists efficiently. The properties of the new estimators were derived. We compared the estimator's performance with the existing estimators theoretically using the mean squared error criterion. Furthermore, we conducted a simulation study and chemical data to evaluate the new estimators’ performance. The theoretical comparison, simulation, and real-life application results established the dominance of the proposed methods.
‘Skeletal Age’ for mapping the impact of fracture on mortality
Authors: Tran Thach , Ho-Le Thao , Bliuc Dana , Abrahamsen Bo , Hansen Louise , Vestergaard Peter , Center Jacqueline R , Nguyen Tuan V 
Published: May 2023

Background:Fragility fracture is associated with an increased risk of mortality, but mortality is not part of doctor-patient communication. Here, we introduce a new concept called ‘Skeletal Age’ as the age of an individual’s skeleton resulting from a fragility fracture to convey the combined risk of fracture and fracture-associated mortality for an individual.Methods:We used the Danish National Hospital Discharge Register which includes the whole-country data of 1,667,339 adults in Denmark born on or before January 1, 1950, who were followed up to December 31, 2016 for incident low-trauma fracture and mortality. Skeletal age is defined as the sum of chronological age and the number of years of life lost (YLL) associated with a fracture. Cox’s proportional hazards model was employed to determine the hazard of mortality associated with a specific fracture for a given risk profile, and the hazard was then transformed into YLL using the Gompertz law of mortality.Results:During the median follow-up period of 16 years, there had been 307,870 fractures and 122,744 post-fracture deaths. A fracture was associated with between 1 and 7 years of life lost, with the loss being greater in men than women. Hip fractures incurred the greatest loss of life years. For instance, a 60-year-old individual with a hip fracture is estimated to have a skeletal age of 66 for men and 65 for women. Skeletal Age was estimated for each age and fracture site stratified by gender.Conclusions:We propose ‘Skeletal Age’ as a new metric to assess the impact of a fragility fracture on an individual’s life expectancy. This approach will enhance doctor-patient risk communication about the risks associated with osteoporosis.Funding:National Health and Medical Research Council in Australia and Amgen Competitive Grant Program 2019.
Identification of immune-related genes in acute myocardial infarction based on integrated bioinformatical methods and experimental verification
Authors: Liu Jian , Chen Lu , Zheng Xiang , Guo Caixia 
Published: May 2023

Background
Acute myocardial infarction (AMI) is one of the leading causes of death worldwide. The etiology of AMI is complex and has not been fully defined. In recent years, the role of immune response in the development, progression and prognosis of AMI has received increasing attention. The aim of this study was to identify key genes associated with the immune response in AMI and to analyze their immune infiltration.

Methods
The study included a total of two GEO databases, containing 83 patients with AMI and 54 healthy individuals. We used the linear model of microarray data (limma) package to find the differentially expressed genes associated with AMI, performing weighted gene co-expression analysis (WGCNA) to further identify the genes associated with inflammatory response to AMI. We found the final hub genes through the protein-protein interaction (PPI) network and least absolute shrinkage and selection operator (LASSO) regression model. To verify the above conclusions, we constructed mice AMI model, extracting myocardial tissue to perform qRT-PCR. Furthermore, the CIBERSORT tool for immune cells infiltration analysis was also carried out.

Results
A total of 5,425 significant up-regulated and 2,126 down-regulated genes were found in GSE66360 and GSE24519. A total of 116 immune-related genes in close association with AMI were screened by WGCNA analysis. These genes were mostly clustered in the immune response on the basis of GO and KEGG enrichment. With construction of PPI network and LASSO regression analysis, this research found three hub genes (SOCS2, FFAR2, MYO10) among these differentially expressed genes. The immune cell infiltration results revealed that significant differences could be found on T cells CD4 memory activated, Tregs (regulatory T cells), macrophages M2, neutrophils, T cells CD8, T cells CD4 naive, eosinophils between controls and AMI patients.
New genicular joint angle criteria for flexor muscle (Musculus Semimembranosus) during the terrestrial mammals walking
Authors: Mizuno Fumihiro , Kohno Naoki 
Published: May 2023

BackgroundThe genicular or knee joint angles of terrestrial mammals remain constant during the stance phase of walking; however, the angles differ among taxa. The knee joint angle is known to correlate with taxa and body mass among extant mammals, yet several extinct mammals, such as desmostylians, do not have closely related descendants. Furthermore, fossils lose their soft tissues by the time they are unearthed, making body mass estimates difficult. These factors cause significant problems when reconstructing the proper postures of extinct mammals. Terrestrial mammals use potential and kinetic energy for locomotion; particularly, an inverted pendulum mechanism is used for walking. This mechanism requires maintaining the rod length constant, therefore, terrestrial mammals maintain their joint angle in a small range. A muscle reaction referred to as co-contraction is known to increase joint stiffness; both the agonist and antagonist muscles work simultaneously on the same joint at the same time. Themusculus semimembranosusflexes the knee joint and acts as an antagonist to muscles that extend it.MethodsTwenty-one species of terrestrial mammals were examined to identify the elements that constitute the angle between them.semimembranosusand the tibia based on the period between the hindlimb touching down and taking off from the ground. Measurements were captured from videos in high-speed mode (420 fps), selecting 13 pictures from the first 75% of each video while the animals were walking. The angles between the main force line of them. semimembranosusand the tibia, which were defined as θsm−t, were measured.ResultsThe maximum and minimum angles between them. semimembranosusand the tibia (θsm−t) of the stance instance (SI) were successfully determined for more than 80% of the target animals (17 out of 21 species) during SI-1 to SI-13 within ±10° from the mean. The difference between each successive SI was small and, therefore, the θsm−ttransition was smooth. According to the results of the total stance differences among the target animals, θsm−twas relatively constant during a stance and, therefore, average θsm−t(θave) can represent each animal. Only Carnivora had a significant difference in the correlation between body mass and θave. In addition, there were significant differences in θavebetween plantigrade and unguligrade locomotion.ConclusionOur measurements show that θavewas 100 ± 10° regardless taxon, body mass, and locomotor mode. Thus, only three points on skeletons need to be measured to determine θave. This offers a new approximation approach for understanding hindlimb posture that could be applied to the study of the hindlimbs of extinct mammals with no closely related extant descendants.
Impact of mini-driver genes in the prognosis and tumor features of colorectal cancer samples: a novel perspective to support current biomarkers
Authors: Campos Segura Anthony Vladimir , Velásquez Sotomayor Mariana Belén , Gutiérrez Román Ana Isabel Flor , Ortiz Rojas César Alexander , Murillo Carrasco Alexis Germán 
Published: May 2023

Background
Colorectal cancer (CRC) is the second leading cause of cancer-related deaths, and its development is associated with the gains and/or losses of genetic material, which leads to the emergence of main driver genes with higher mutational frequency. In addition, there are other genes with mutations that have weak tumor-promoting effects, known as mini-drivers, which could aggravate the development of oncogenesis when they occur together. The aim of our work was to use computer analysis to explore the survival impact, frequency, and incidence of mutations of possible mini-driver genes to be used for the prognosis of CRC.

Methods
We retrieved data from three sources of CRC samples using the cBioPortal platform and analyzed the mutational frequency to exclude genes with driver features and those mutated in less than 5% of the original cohort. We also observed that the mutational profile of these mini-driver candidates is associated with variations in the expression levels. The candidate genes obtained were subjected to Kaplan–Meier curve analysis, making a comparison between mutated and wild-type samples for each gene using a p-value threshold of 0.01.

Results
After gene filtering by mutational frequency, we obtained 159 genes of which 60 were associated with a high accumulation of total somatic mutations with Log2 (fold change) > 2 and p values < 10−5. In addition, these genes were enriched to oncogenic pathways such as epithelium-mesenchymal transition, hsa-miR-218-5p downregulation, and extracellular matrix organization. Our analysis identified five genes with possible implications as mini-drivers: DOCK3, FN1, PAPPA2, DNAH11, and FBN2. Furthermore, we evaluated a combined classification where CRC patients with at least one mutation in any of these genes were separated from the main cohort obtaining a p-value < 0.001 in the evaluation of CRC prognosis.

Conclusion
Our study suggests that the identification and incorporation of mini-driver genes in addition to known driver genes could enhance the accuracy of prognostic biomarkers for CRC.
Characteristics of the Household-Scale Fisheries Industry in West Java, Indonesia
Authors: Junianto  , Ayuningtyas Astrid Puspita , Nuriyah Dita 
Published: May 2023

Aims: The fact that level of fish consumption in Indonesia is relatively low in 2021 at 55.16 kg/capita compared to the fishery production which has reached 21,872,810.30 tonnes. One of the causes is the lack of various types of processed fishery products on the market which makes people tend to get bored consuming fishery products, one of the efforts that can be taken is to increase the household-scale fisheries industry. Therefore, it is necessary to carry out further research on the characterization of the household-scale fisheries industry to determine its characteristics as well as to be used as a reference for increasing fish consumption in the future.
Study Design: A Case study.
Place and Duration of Study: Several areas in West Java, such as Sumedang Regency, Bogor Regency, Bandung City, and Depok City, 1 March 2023 - 31 March 2023 (1 month).
Methodology: This research was conducted by taking random samples and analyzing using descriptive analysis with 6 interviewees (4 men and 2 women).
Results: The procurement of raw materials is purchased by business owners at the nearest local market with cash payments and an open system. The use of the means of production is still simple. Own innovation recipe. Some have implemented a factory layout, some don't have a factory layout. Doing market segmentation properly, targeting all groups, products are distributed directly to consumers. Promotion techniques are carried out online following existing technological developments. Determine the cost-plus pricing method. The majority have competitors located around the industry.
Conclusion: The duration of opening a business and the level of education can affect a person's experience and understanding of doing business. Always prioritizing cleanliness, the quality of raw materials, the technology used, and the quality of the final product can affect the progress of an industrial business.
Another 18th-century reference to Arthur's Oven
Authors: Dunshea Philip 
Published: May 2023

The interest of the early antiquaries in the monument known as Arthur’s Oven is well documented (Steer 1958; Brown 1974; Steer 1976; Brown &
Vasey 1989). Almost certainly a Roman triumphal memorial, the Oven stood on the north bank of the Carron near Stenhousemuir (NGR NS 879 827) until it was demolished in 1743 to provide stone for a mill dam.