bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lymphological Liposculpture for Secondary Lymphedema after Breast Cancer and Gynecological Tumors: Long-Term Results after 15 Years
Authors: Cornely Manuel E. 
Published: May 2023

AbstractBackground Untreated lymphedema of an extremity leads to an increase in volume. The therapy of this condition can be conservative or surgical.Methods “Lymphological liposculpture” is a two-part procedure consisting of resection and conservative follow-up treatment to achieve curative volume adjustment of the extremities in secondary lymphedema. This treatment significantly reduces the need for complex decongestive therapy (CDT). From 2005 to 2020, 3,184 patients with secondary lymphedema after breast cancer and gynecological tumors were treated in our practice and clinic. “Lymphological liposculpture” was applied to 65 patients, and the data were recorded and evaluated by means of perometry and questionnaires.Results The alignment of the sick to the healthy side was achieved in all patients. In 58.42% (n = 38), the CDT treatment could be completely stopped postoperatively; in another 33.82% (n = 22) of the patients, a permanent reduction of the CDT was achieved. In 7.69% (n = 5) patients, the postoperative CDT could not be reduced. A total of 92.30% (n = 60) of the patients described a lasting significant improvement in their quality of life.Conclusion “Lymphological liposculpture” is a standardized curative sustainable procedure for secondary lymphedema for volume adjustment of the extremities and reduction of postoperative CDT with eminent improvement of the quality of life.
Mobile Health-Technology-Integrated Care for Atrial Fibrillation: A Win Ratio Analysis from the mAFA-II Randomized Clinical Trial
Authors: Romiti Giulio Francesco , Guo Yutao , Corica Bernadette , Proietti Marco , Zhang Hui , Lip Gregory Y. H. ,   on behalf of the mAF-App II trial investigators
Published: May 2023

Background The Mobile Health (mHealth) Technology for Improved Screening and Optimized Integrated Care in atrial fibrillation (AF) (mAFA-II) cluster randomized trial assessed the efficacy of an integrated care approach in improving the prognosis of AF patients. In this study, we provide a reanalysis of the trial outcomes using the win ratio (WR) approach.
Methods The mAFA-II trial allocated patients to receive a mHealth-technology implemented Atrial Fibrillation Better Care (ABC) pathway (mAFA intervention) or usual care. The primary outcome was the composite of all-cause death, ischemic stroke or systemic thromboembolism, and rehospitalization. The efficacy of the mAFA intervention was analyzed according to the WR method using the unmatched pairs approach, with the components of the primary outcome analyzed hierarchically as follows: (1) all-cause death; (2) ischemic stroke or thromboembolism; (3) rehospitalization. Results were reported as WR and 95% confidence intervals (CIs). In addition, we calculated win odds (WO) and 95% CI.
Results A total of 3,324 patients were enrolled in the mAFA-II trial and included in this analysis (1,646 allocated to mAFA intervention and 1,678 to usual care). Among 2,761,988 unmatched pairs comparisons, the number of wins was higher in the mAFA intervention group, with a WR: 2.78 (95% CI: 1.85–4.17). WO confirmed the effect of mAFA intervention, although with a lower magnitude (WO: 1.06; 95% Cl: 1.04–1.08).
Conclusion In this posthoc WR analysis of the mAFA-II trial, a mHealth-technology-implemented integrated care approach was effective in reducing the risk of the primary composite outcome of all-cause death, ischemic stroke or thromboembolism, and rehospitalization, even when prioritizing fatal events.
New Zealanders with low back pain seeking health care: a retrospective descriptive analysis of Accident Compensation Corporation-funded low back pain healthcare service usage
Authors: Hill Julia , Kay Dylan , Gordon Jacob , Niazi Imran Khan , Saywell Nicola 
Published: May 2023

Introduction Most New Zealanders experience low back pain (LBP) at least once throughout their lifetime and many seek help from the large range of health providers in primary care. Accident Compensation Corporation (ACC) funds a significant proportion of those claims, but which services are they funding and what are the costs? Method This was a retrospective audit and descriptive analysis of ACC-funded, non-public hospital healthcare service use by people with LBP in New Zealand (NZ). Outcome measures were the healthcare services accessed by people with ACC-funded LBP,the claims (all occurrences for a service that has generated a payment/year), single contact (with a service), and costs (NZ$) for services between 2009 and 2020. Results The number of claims for services were 129 000 for physiotherapy, 105 000 for general practitioner and 59 000 for radiology services. Per single contact, elective surgery and radiology services were the most expensive. During 2009–2020, there were 3.3 million ACC claims for LBP with a total cost of NZ$4 billion. Over this time, there was an increase in claims, costs and single contacts. Costs decreased slightly during 2010 due to changes in healthcare funding and in 2020 due to the COVID-19 pandemic. Discussion Consumers have considerable choice in where they access health care for ACC-funded LBP services. This study shows the services they use most frequently and the cost to NZ for those services. These data can inform service planning for ACC-funded LBP health care in NZ.
A corpus-driven description ofoin Naijá (Nigerian Pidgin)
Authors: Manfredi Stefano , Čéplö Slavomír 
Published: May 2023

AbstractWidely attested in both creole and non-creole languages of the Atlantic basin, the function wordohas been traditionally described as a ‘sentence/phrase final particle’, owing to its typical syntactic behaviour, rather than to its multiple grammatical meanings. Based on the corpus-driven analysis of the NaijaSynCor, a ~400K words corpus of spoken Naijá (i.e., Nigerian Pidgin), this study suggests that sentence-finalocan be better described as an ‘illocutionary force indicator’ whose main pragmatic function is to modify the illocutionary force associated with directive and assertive speech acts. The study also provides evidence for the emergence of new coordinating and subordinating functions ofoin intra-sentential position that are semantically harmonic with its assertive (i.e. epistemic) meaning in sentence-final position. The corpus-driven analysis further shows that the higher occurrence of sentence-finaloin (formal and informal) dialogic texts in comparison to monologic texts is a reflex of its basic illocutionary function.
Deprescribing to optimise health outcomes for frail older people: a double-blind placebo-controlled randomised controlled trial—outcomes of the Opti-med study
Authors: Etherton-Beer Christopher , Page Amy , Naganathan Vasi , Potter Kathleen , Comans Tracy , Hilmer Sarah N , McLachlan Andrew J , Lindley Richard I , Mangin Dee 
Published: May 2023

Abstract

Background
potentially harmful polypharmacy is very common in older people living in aged care facilities. To date, there have been no double-blind randomised controlled studies of deprescribing multiple medications.

Methods
three-arm (open intervention, blinded intervention and blinded control) randomised controlled trial enrolling people aged over 65 years (n = 303, noting pre-specified recruitment target of n = 954) living in residential aged care facilities. The blinded groups had medications targeted for deprescribing encapsulated while the medicines were deprescribed (blind intervention) or continued (blind control). A third open intervention arm had unblinded deprescribing of targeted medications.

Results
participants were 76% female with mean age 85.0 ± 7.5 years. Deprescribing was associated with a significant reduction in the total number of medicines used per participant over 12 months in both intervention groups (blind intervention group −2.7 medicines, 95% CI −3.5, −1.9, and open intervention group −2.3 medicines; 95% CI −3.1, −1.4) compared with the control group (−0.3, 95% CI −1.0, 0.4, P = 0.053). Deprescribing regular medicines was not associated with any significant increase in the number of ‘when required’ medicines administered. There were no significant differences in mortality in the blind intervention group (HR 0.93, 95% CI 0.50, 1.73, P = 0.83) or the open intervention group (HR 1.47, 95% CI 0.83, 2.61, P = 0.19) compared to the control group.

Conclusions
deprescribing of two to three medicines per person was achieved with protocol-based deprescribing during this study. Pre-specified recruitment targets were not met, so the impact of deprescribing on survival and other clinical outcomes remains uncertain.
Distribution of multiunit pitch responses recorded intracranially from human auditory cortex
Authors: Berger Joel I , Gander Phillip E , Kikuchi Yukiko , Petkov Christopher I , Kumar Sukhbinder , Kovach Christopher , Oya Hiroyuki , Kawasaki Hiroto , Howard Matthew A , Griffiths Timothy D 
Published: May 2023

Abstract
The perception of pitch is a fundamental percept, which is mediated by the auditory system, requiring the abstraction of stimulus properties related to the spectro-temporal structure of sound. Despite its importance, there is still debate as to the precise areas responsible for its encoding, which may be due to species differences or differences in the recording measures and choices of stimuli used in previous studies. Moreover, it was unknown whether the human brain contains pitch neurons and how distributed such neurons might be. Here, we present the first study to measure multiunit neural activity in response to pitch stimuli in the auditory cortex of intracranially implanted humans. The stimulus sets were regular-interval noise with a pitch strength that is related to the temporal regularity and a pitch value determined by the repetition rate and harmonic complexes. Specifically, we demonstrate reliable responses to these different pitch-inducing paradigms that are distributed throughout Heschl’s gyrus, rather than being localized to a particular region, and this finding was evident regardless of the stimulus presented. These data provide a bridge across animal and human studies and aid our understanding of the processing of a critical percept associated with acoustic stimuli.
Artistic, Artworld, and Aesthetic Disobedience
Authors: Burgos Adam , Lintott Sheila 
Published: May 2023

Abstract
Jonathan Neufeld proposes a concept of aesthetic disobedience that parallels the political concept of civil disobedience articulated by John Rawls in A Theory of Justice. The artistic transgressions he calls aesthetic disobedience are distinctive in being public and deliberative in their aim to bring about specific changes in accepted artworld norms. We argue that Neufeld has offered us valuable insight into the dynamic and potent nature of art and the artworld; however, we contend that Neufeld errs by constraining aesthetic disobedience to the artworld. Through a reconsideration of the parallel between aesthetic and civil disobedience, we illustrate how aesthetic disobedience is more accurately conceived of in terms of two kinds of acts: artistic and artworld. In addition to artistic disobedience and artworld disobedience, we add a broader and more diverse sort of transgressive aesthetic disobedience. Our aim is to articulate how Neufeld’s account of a kind of disobedience in the artworld that parallels civil disobedience can prove even more generative.
Presence of nontarget prey, Tetranychus truncatus, affected the predation by Neoseiulus bicaudus on Tetranychus turkestani
Authors: Hu Hengxiao , Tang Siqiong , Fang Chen , Mu Kaiqin , Su Jie , Zhang Jianping 
Published: May 2023

Abstract
Neoseiulus bicaudus (Wainstein) (Acari: Phytoseiidae) is a generalist predatory mite that consumes several pest species, including Tetranychus turkestani (Ugarov et Nikolskii) (Acari: Tetranychidae) in the Xinjiang Uygur Autonomous Region. The release numbers of predatory mites are based on the populations of target pests and their ability to control them. Populations of T. turkestani and T. truncatus Ehara (Acari: Tetranychidae) often coexist and damage many crops. To determine whether the presence of the non-target prey T. truncatus affects the ability of N. bicaudus to control the target prey T. turkestani. The study evaluated the predation rate and functional response of N. bicaudus to 4 stages of T. turkestani in the presence of T. truncatus. The consumption of T. turkestani by N. bicaudus gradually decreased as the proportion of T. truncatus increased. The functional response of N. bicaudus to T. turkestani was not changed when T. truncatus was presented, which was consistent with a type II response. The attack rate of N. bicaudus on the egg, larva, and nymph of T. turkestani was significantly decreased and the handling time of N. bicaudus on T. turkestani was significantly extended when T. truncatus was presented. The preference index showed that the preference of N. bicaudus for eggs and female adults of T. turkestani decreased with increasing density of T. turkestani in the same proportion as T. truncatus. The presence of T. truncatus can negatively affect the predation of T. turkestani by N. bicaudus. We suggest that the number of N. bicaudus released to control T. turkestani should be increased when T. truncatus coexist.
Seasonal patterns of beneficial phytochemical availability in honey and stored pollen from honey bee colonies in large apiaries
Authors: Bernklau Elisa , Arathi H S 
Published: May 2023

Abstract
Honey bees (Apis mellifera L.; Hymenoptera, Apidae) are the most efficient pollinators in agroecosystems, responsible for the successful production of fruits, nuts, and vegetables, but they continue to face debilitating challenges. One of the major factors leading to these challenges could be linked to poor nutrition that results in weakening the colony, increasing susceptibility to pests and pathogens, and reducing the ability of bees to adapt to other abiotic stresses. Extensively used for commercial pollination, honey bee colonies regularly face exposure to limited diversity in their pollen diet as they are placed in flowering monocrops. Lack of access to diverse plant species compromises the availability of plant secondary compounds (phytochemicals), which, in small amounts, provide significant benefits to honey bee health. We analyzed the beneficial phytochemical content of honey and stored pollen (bee bread) samples from colonies in large apiaries through the active bee season. Samples were evaluated for 4 beneficial phytochemicals (caffeine, kaempferol, gallic acid, and p-coumaric acid), which have previously been shown to improve honey bee health. Our results, as relevant to the apiary locations in the study, indicated that p-coumaric acid is uniformly available throughout the season. Caffeine is completely absent, and gallic acid and kaempferol are not regularly available. Our results suggest the need to explore the potential to deliver beneficial phytochemicals as nutritional supplements to improve bee health. It may be vital for the pollination industry to consider such targeted dietary supplementation as beekeepers strive to meet the increasing demand for crop pollination services.
Thulium laser vaporesection of prostates with volume exceeding 100 cm3 as an alternative to HoLEP and ThuLEP
Authors: Paesano Nahuel , Castañeda Gonzalo , Maccagno Alicia , Caldas Paulo , Chechile Gilberto 
Published: May 2023

Abstract
The aim of this study is to evaluate the outcomes of thulium laser vaporesection of prostates with volume exceeding 100 cm3. In the present prospective study, patients with infra-vesical urinary obstruction due to a prostate with volume exceeding 100 cm3 underwent endoscopic vaporesection using thulium laser. In this procedure, prostate chips were resected without morcellation. The technical aspects of surgery, admission time, post-operative catheter time and post-operative complications were analyzed. Flowmetry was performed combined with prostatic ultrasound in the follow-up. Between March 2010 and November 2018, 156 cases with benign prostatic hyperplasia (BPH; volume &gt;100 cm3) were treated. The mean patient age was 67.8 years (48.4–86.6 years), and the mean prostatic volume was 137 cm3 (100–436 cm3). The mean length of hospitalization was 1.48 days (1–8 days), and the mean post-operative catheter time was 5.1 (1–17). Three cases (1.9%) required readmission due to hematuria. The mean follow-up time was 31.2 months (standard deviation = 27.7). Urethral stricture was observed in 14 cases (9%), with bulbar urethra being the most frequent finding. Urinary tract infection was observed in 11 cases (7.1%), and urinary incontinence was observed in 5 cases. The mean peak urinary flow at 12 and 24 months was 26.9 ± 12.5 and 23.9 ± 11.7 ml/s, respectively, and the mean urinary flow during the final follow-up at 41 months was 21.6 ml/s. Thulium laser vaporesection is a valid alternative to open prostatectomy, HoLEP and ThuLEP in patients with large BPH. Urinary flow remained elevated throughout the follow-up.
Non-specific LIPID TRANSFER PROTEIN 1 enhances immunity against tobacco mosaic virus in Nicotiana benthamiana
Authors: Zhu Feng , Cao Meng-Yao , Zhu Peng-Xiang , Zhang Qi-Ping , Lam Hon-Ming 
Published: May 2023

Abstract
Plant non-specific lipid transfer proteins (nsLTPs) are small, cysteine-rich proteins that play significant roles in biotic and abiotic stress responses; however, the molecular mechanism of their functions against viral infections remains unclear. In this study, we employed virus-induced gene-silencing and transgenic overexpression to functionally analyse a type-I nsLTP in Nicotiana benthamiana, NbLTP1, in the immunity response against tobacco mosaic virus (TMV). NbLTP1 was inducible by TMV infection, and its silencing increased TMV-induced oxidative damage and the production of reactive oxygen species (ROS), compromised local and systemic resistance to TMV, and inactivated the biosynthesis of salicylic acid (SA) and its downstream signaling pathway. The effects of NbLTP1-silencing were partially restored by application of exogenous SA. Overexpressing NbLTP1 activated genes related to ROS scavenging to increase cell membrane stability and maintain redox homeostasis, confirming that an early ROS burst followed by ROS suppression at the later phases of pathogenesis is essential for resistance to TMV infection. The cell-wall localization of NbLTP1 was beneficial to viral resistance. Overall, our results showed that NbLTP1 positively regulates plant immunity against viral infection through up-regulating SA biosynthesis and its downstream signaling component, NONEXPRESSOR OF PATHOGENESIS-RELATED 1 (NPR1), which in turn activates pathogenesis-related genes, and by suppressing ROS accumulation at the later phases of viral pathogenesis.
Whole-exome sequencing reveals a likely pathogenic LMNA variant causing hypertrophic cardiomyopathy
Authors: Mahdavi Mohammad , Mohsen-Pour Neda , Maleki Majid , Ghasemi Serwa , Tabib Avisa , Houshmand Golnaz , Naderi Niloofar , Masoumi Tannaz , Pouraliakbar Hamidreza , Kalayinia Samira 
Published: May 2023

Abstract

Objective
We studied the clinical and molecular features of a family with hypertrophic cardiomyopathy (HCM).

Background
A very heterogeneous disease affecting the heart muscle, HCM is mostly caused by variants in the proteins of sarcomeres. The detection of HCM pathogenic variants can affect the handling of patients and their families.

Methods
Whole-exome sequencing (WES) was performed to assess the genetic cause(s) of HCM in a consanguineous Iranian family.

Results
Missense likely pathogenic variant c.1279C&gt;T (p.Arg427Cys) within exon 7 of the LMNA gene (NM_170707) was found. The segregations were confirmed by polymerase chain reaction–based Sanger sequencing.

Conclusions
Variant c.1279C&gt;T (p.Arg427Cys) in the LMNA gene seemed to have been the cause of HCM in the family. A few LMNA gene variants related to HCM phenotypes have been recognized so far. Identifying HCM genetic basis confers significant opportunities to understand how the disease can develop and, by extension, how this progression can be arrested. Our study supports WES effectiveness for first-tier variant screening of HCM in a clinical setting.
A rapid protocol for ribosome profiling of low input samples
Authors: Meindl Andreas , Romberger Markus , Lehmann Gerhard , Eichner Norbert , Kleemann Leon , Wu Jie , Danner Johannes , Boesl Maria , Mesitov Mikhail , Meister Gunter , König Julian , Leidel Sebastian Andreas , Medenbach Jan 
Published: May 2023

Abstract
Ribosome profiling provides quantitative, comprehensive, and high-resolution snapshots of cellular translation by the high-throughput sequencing of short mRNA fragments that are protected by ribosomes from nucleolytic digestion. While the overall principle is simple, the workflow of ribosome profiling experiments is complex and challenging, and typically requires large amounts of sample, limiting its broad applicability. Here, we present a new protocol for ultra-rapid ribosome profiling from low-input samples. It features a robust strategy for sequencing library preparation within one day that employs solid phase purification of reaction intermediates, allowing to reduce the input to as little as 0.1 pmol of ∼30 nt RNA fragments. Hence, it is particularly suited for the analyses of small samples or targeted ribosome profiling. Its high sensitivity and its ease of implementation will foster the generation of higher quality data from small samples, which opens new opportunities in applying ribosome profiling.
sfkit: a web-based toolkit for secure and federated genomic analysis
Authors: Mendelsohn Simon , Froelicher David , Loginov Denis , Bernick David , Berger Bonnie , Cho Hyunghoon 
Published: May 2023

Abstract
Advances in genomics are increasingly depending upon the ability to analyze large and diverse genomic data collections, which are often difficult to amass due to privacy concerns. Recent works have shown that it is possible to jointly analyze datasets held by multiple parties, while provably preserving the privacy of each party’s dataset using cryptographic techniques. However, these tools have been challenging to use in practice due to the complexities of the required setup and coordination among the parties. We present sfkit, a secure and federated toolkit for collaborative genomic studies, to allow groups of collaborators to easily perform joint analyses of their datasets without compromising privacy. sfkit consists of a web server and a command-line interface, which together support a range of use cases including both auto-configured and user-supplied computational environments. sfkit provides collaborative workflows for the essential tasks of genome-wide association study (GWAS) and principal component analysis (PCA). We envision sfkit becoming a one-stop server for secure collaborative tools for a broad range of genomic analyses. sfkit is open-source and available at: https://sfkit.org.