bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of Readiness across Tertiary/University Teaching Hospitals in a Developing Country Nigeria to Implement Sustainable Healthcare Digital Transformation Programmes and Projects
Authors: Onyeabor Uchechukwu Solomon , Ayoola Lasebikan Omolade , Okenwa Wilfred Okwudili , Onwuasoigwe Okechukwu , Schaaf Thorsten , Pinkwart Niels , Balzer Felix 
Published: September 2023

Abstract

Background
The gains of healthcare's digital transformation have become phenomenal! Several healthcare institutions and providers across the globe witnessed massive integration of digital technologies (particularly during the COVID-19 crisis) to optimise healthcare service delivery. Given its massive benefits, it is also important to note that the success of digital transformation programmes and projects within any context, including healthcare, could largely depend on the readiness of the implementation environment to receive, adopt, adapt, or integrate such programmes and projects. The goal of this research was therefore to conduct an assessment of readiness across three tertiary/university hospitals in a developing country, Nigeria, to implement sustainable healthcare digital transformation programmes and projects.
Method
This research was based on quantitative methods. A survey based on a 5-point Likert Scale was distributed to clinical stakeholders across these institutions on the readiness of the institutions and stakeholders to implement healthcare digital transformation programmes and projects. A sample population of 600 clinicians was surveyed. Specifically, the survey evaluated the perceptions of clinicians on different dimensions of readiness measurements. The Data analysis and visualisation were done using SPSS and MS Excel.
Result
Out of the 600 clinicians surveyed across the three tertiary/university teaching hospitals, 580 usable questionnaires for data analysis were retrieved, which was indicative of a 96.67% success rate. On the dimension of ‘vision clarity’, 90.40% of the clinicians posited that a computer-based system was indeed needed to improve their clinical procedures. But when asked if all staff in their units were highly computer literate to support digital transformation projects, only 30% of the respondents believed that staff were highly computer literate. When this question was reframed and the respondents were asked to confirm that staff in their unit really had low computer skills, again, only 36.30% of respondents thought otherwise.
Conclusion
Our result clearly shows that low digital literacy was a major challenge across the hospitals surveyed. And without a significant level of computer literacy, there would hardly be any healthcare digital transformation project that would be sustainable. There is a need for concerted effort in the area of massive training of the clinical workforce in this area.
BCL2L1 is regulated by the lncRNA MIR4435-2HG-miR-513a-5p-BCL2L1 ceRNA axis and serves as a biomarker for pancreatic adenocarcinoma treatment and prognosis
Authors: Zhu Rongkun , Chen Wei , Bai Shanwang , Chang Liang , Li Zhen , Liu Fashun 
Published: September 2023

Abstract

Pancreatic adenocarcinoma (PAAD) is one of the most malignant cancers. After escaping death, cancer cells are made more metastatic, aggressive, and also drug-resistant through anoikis resistance. The aim of this study is to explore the molecular mechanisms of anoikis-related genes in PAAD and to identify potential key biomarkers. We integrated information about PAAD from The Cancer Genome Atlas (TCGA) and The Genotype-Tissue Expression (GTEx) databases and identified anoikis-related gene BCL2L1 by survival analysis, univariate Cox regression analysis, and multifactorial Cox regression analysis. Various bioinformatics approaches showed that BCL2L1 was a valuable prognostic marker that might be involved in PAAD development and progression through different mechanisms, including cancer intervention, genomic heterogeneity, and RNA modifications. Our analysis showed that BCL2L1 expression also closely correlates with the expression of various immune checkpoint inhibitors. In particular, we found that long non-coding RNA MIR4435-2HG acted as ceRNA sponging miR-513a-5p to promote the expression of BCL2L1, thereby promoting pancreatic cancer cells proliferation. In conclusion, BCL2L1 expression regulated by the MIR4435-2HG-miR-513a-5p-BCL2L1 ceRNA axis might be used as a biomarker for cancer prognosis, treatment selection, and follow-up in PAAD patients.
Efficacy of Nicorandil in Preventing Contrast-Induced Nephropathy in Patients with ST-segment Elevation Myocardial Infarction undergoing Primary Percutaneous Coronary Intervention
Authors: QIAN GENG , Chen Si , Jiang Xiao-si , Zhang Ying , A Xin , Li Ping , Chen Yun-dai 
Published: September 2023

Abstract
Objective:
It is widely reported that nicorandil could reduce contrast-induced nephropathy (CIN) after selective percutaneous coronary intervention (PCI) or coronary angiography. The aim of this multi-center prospective randomized controlled trial is to evaluate the efficacy of nicorandil for the prevention of CIN during primary PCI in patients with ST-segment elevation myocardial infarction (STEMI).
Methods:
Patients with STEMI received primary PCI were enrolled, and they were randomly assigned into nicorandil group and placebo group, receiving intravenous nicorandil or placebo, respectively. The endpoint was the incidence of CIN, defined as an absolute increase in serum creatinine (SCr) > 0.5 mg/dl or a relative increase > 25% compared with baseline SCr. The secondary endpoints were major adverse cardiovascular events (MACEs) within a year.
Results:
The final study population comprised 238 randomized patients, and 226 of them (n=113 for each group) were included in the primary analysis. Compared with the placebo group, the final TIMI grade in the nicorandil group was significantly better (P = 0.001), and the incidence of CIN in nicorandil group was significantly lower (9.7% (11/113) vs. 24.8% (28/113), P = 0.003). The logistic regression analysis revealed that nicorandil was significantly associated with the decreased odds of CIN (OR: 0.379, 95% CI: 0.166-0.861, P=0.021). Nicorandil is an independent protective factor for the development of CIN in STEMI patients undergoing primary PCI.
Conclusions:
Our study indicated that intravenous nicorandil could prevent CIN in patients with STEMI undergoing primary PCI.
Effect of choline chloride-ethylene glycol manipulation on electropolishing of metallic nickel
Authors: karim wrya 
Published: September 2023

Abstract
This study presents effectiveness of electrolytic bath on successful electropolishing of metallic nickel. The electrolytic bath consists of choline chloride (ChCl) and ethylene glycol (EG). The different mole ratios of these two components were prepared; namely, 1:2, 1:3, 1:4. As electrolytic bath, ChCl: EG was applied to make smooth metallic nickel electrochemically. The electrochemical conditions of the electropolishing of metallic nickel were obtained by holding the voltage at 1.5 V for 12 min at 25°C. Comparison is made with analogous measurements for three electrolytic bathes in electropolishing of metallic nickel.
A nomogram for lateral lymph nodes that have metastatic cN0 unifocal papillary thyroid microcarcinoma
Authors: Saad Hassan A , Farid Mohamed I , Eraky Mohamed E , El-Taher Ahmed K , Baz Azza , Riad Mohamed 
Published: September 2023

Abstract
Background
The need for lateral neck dissection (LND) in papillary thyroid microcarcinoma (PTMC) might be better understood by identifying risk variables for occult lateral lymph node metastasis (LLNM). This study's goal was to create a nomogram for predicting the likelihood of LLNM in individuals with cN0 unifocal PTMC.
Methods
A total of 9744 patients with cN0 unifocal PTMC who had treatment at our facility between February 2013 and April 2020 were the subject of our retrospective analysis. The risk variables for LLNM were identified using logistic regression analysis, and a nomogram was created based on these risk factors.
Results
3.2% of the population had LLNM. Compared to tumours in the lower or middle lobe with a size less than or equal to 7 mm, tumours in the upper lobe had a substantially increased risk of LLNM (odds ratio [OR] = 2.56, 95% confidence interval [CI] 1.80–3.62; p 0.001) and OR = 2.59, 95% CI 1.85–3.62. ETE tumours had a significantly increased probability of developing LLNM (OR = 1.41, 95% CI 1.01–1.99; p = 0.044). One or two central lymph node metastases (CLNMs) or three or more of them (OR = 5.84, 95% CI 3.83-8.93; p 0.001) increased the probability of LLNM in comparison to having none (OR = 2.91, 95% CI 1.93-4.42; p 0.001). The receiver operating characteristic (ROC) curve of a nomogram that took these risk factors into account showed an area under the curve (AUC) of 0.777, indicating a good level of predictive accuracy.
Conclusion
Three or more CLNMs, especially three or more, and upper lobe tumours larger than 7 mm in size were independent risk factors for LLNM in cN0 unifocal PTMC. Based on these variables, the nomogram showed good predictive value and consistency.
Can reparation deliver equality? Projections for the shared socioeconomic pathways in the USA
Authors: Shayegh Soheil 
Published: September 2023

Abstract
Reparations in terms of direct payments are often used to redress injustices and compensate for historical inequalities. In some parts of the United States, restoring the deferred wealth of Black population through reparations has gained traction in recent years. However, there is no consensus on which reparative policies should be implemented and how to assess their potential impact. Here we show that reparative taxation of White population can be an effective measure in closing the racial wealth gap. We found that imposing a hypothetical one-time reparative estate tax of 5% can potentially close the racial wealth gap among all skill groups (high-skilled, low-skilled, and combined). However, the impact of such reparation shock on closing the wealth gap between high-skilled and low-skilled labor can be observed only among Black population. Nevertheless, the impact of imposing a similar one-time reparative inheritance tax of 5% is less profound in closing the racial wealth gap. Overall, the low-skilled Black sub-population emerges as the group benefiting the most from these hypothetical taxation schemes. These results show how reparation policies in the form of taxation of intergenerational wealth transfers can help close the racial wealth gap while having a short-lived impact on the skill-based wealth gap. The structural economic model of overlapping generations proposed in this paper can be considered a stepping stone to the incorporation of intergenerational and interracial inequalities into the shared socioeconomic pathways (SSPs).
JEL Classification: J15 , D63 , D31
Investigation of MDR1 Gene Polymorphism and Losartan Plasma Concentration in Patients Undergoing Hypertensive Episodes While under Losartan Treatment
Authors: Cimen Uzeyir , Tug Esra , Nesetoglu Neset , Unal Duri Sehvar , Karakuş Osman , Cimen Yesim Kinaci , Kadi Gültekin , Turan Ömer Faruk , Demircan Ahmet , Uluoglu Canan 
Published: September 2023

Abstract
Purpose: Losartan, a drug in the angiotensin receptor blocker (ARB) family, is the substrate of the Multi Drug Resistance-1 (MDR1) drug-efflux protein encoded by the ABCB1 gene. This study seeks to investigate the MDR1 gene polymorphism and losartan concentration in order to identify drug resistance in patients presenting to the emergency department (ED) with a hypertensive episode while having losartan treatment.
Methods: The ethics approval of our study was granted by Gazi University Clinical Research Ethics Committee (dateof registration 23.10.2017, number: 496) and Ministry of Health Turkey Medicines and Medical Devices Agency (date of registration 14.02.2018, code number: 17-AKD-189). The patient cohort was comprised of 50 individuals presenting with a hypertensive episode while under losartan treatment. The control cohort included 50 patients whose blood pressure was regulated while receiving losartan treatment and who were admitted to the ED for reasons other than hypertensive episode. Allele-specific analysis was carried out PCR (Polymerase Chain Reaction) device. Plasma losartan and EXP3174 levels of the patients were measured using tandem mass spectrometry.
Results: The frequencies of GG, GT, GA, TA and TT genotypes did not differ significantly between the cohorts in G2677T/A single nucleotide polymorphism (SNP) (p>0.05), whereas those of C3435T TT and C1236T CT genotypes yielded a significant difference between the patient and control cohorts (p<0.05).
Conclusion: We provided clinical evidence that hypertensive episodes occurred more frequently in C3435T TT and less frequently in C1236T CT. However, no significant correlation was established between plasma losartan, EXP3174 concentration and G2677T/A, C3435T, and C1236T genotypes.
American Clinical Trials Registration Number: NCT05349825
The Study on Occupational Radiation Protection at Bhaktapur Cancer Hospital by Analyzing Dosimetric Data
Authors: Khatiwada Richa , Jha Bidyapati , Pokhrel Prashansa , Jha Vinaya Kumar 
Published: September 2023

Abstract
Radiation is the release of energy in the form of electromagnetic waves or particles, and it is used for cancer treatment for therapeutic treatments like radiation therapy as well as diagnostic imaging methods like X-rays. However, the use of radiation in cancer hospitals presents an occupational hazard for medical workers who are exposed to it, necessitating rigorous adherence to safety procedures, suitable shielding, and monitoring to reduce the risk of radiation-related health impacts. This research analyzes the distribution of radiation exposure levels among Bhaktapur Cancer Hospital (BCH) personnel over a number of years. The data shows that the mean exposure levels in 2011 and 2012 were relatively low, with only one employee having a non-zero exposure value each year. The mean exposure levels fluctuated throughout the years but were largely within acceptable limits. However, an exception was found in 2022, where the maximum exposure value was substantially greater than in previous years, with the highest exposure of 5 mSv for one of the employees. This anomaly might be related to decreased functioning of specific devices during the COVID-19 pandemic and an increase in patients following the pandemic. Overall, the radiation exposure of employees during the evaluated years (2011-15 and 2021-22) was found to be within the safe level. Moreover, the cumulative life exposure up to 2015 was below the recommended safety limit. The study emphasizes hospital radiation safety with protective gear, shielding, and dosimeter monitoring. Besides this given exposure, when incorporating the background radiation absorbed in the supervised region requiring TLD placement, the calculated value within BCH was determined to be 1.4025 mSv. Furthermore, the combined highest and lowest sum of individual total exposures during work hours, inclusive of background radiation, was found to be (1.4025 and 6.4025) mSv, respectively. This total also falls within the safety limit set by the ICRP(International Commission on Radiological Protection ). However, even if the radiation exposure is within the safety limit, cumulative exposure over the years can have hazardous effects on health workers.
Impact the solar ventilation on thermal comfort and energy efficiency of buildings using phase change materials.
Authors: BENACHIR NOUHAILA , Farida Bendriaa , MOUHIB TAOUFIQ 
Published: September 2023

Abstract

This article aims to provide an overview of best practices for the design and construction of more energy efficient building envelopes. So the effects of carbon fuel consumption on the environment have stimulated development of a ‘net-zero’ energy measurement in buildings envelope for sustainable buildings a net-zero energy is key to reducing energy use and saving money .For several decades, low-income citizens in Moroccan cities have been suffering from thermal inequality, energy poverty and thermal comfort constraints. They resist indoor temperatures of less than 16°C and more than 32°C, which causes the phenomenon of thermal stress. Among the sources of energy consumption, Heating, Ventilation and Air Conditioning (HVAC) systems represent about 50% of the total expenditure in buildings this considerable proportion can be explained in part by the great temperature variations recorded in Morocco, which make it essential to provide air conditioning or heating almost at all times. The development of green buildings thus inevitably requires an optimization of the use of HVAC SYSTEMS. The article presents the integrated the mechanical solar ventilation and phase change materials into the building envelope using the simulation software of the thermal behavior in dynamic regime TRNSYS, this project aims at the design of a single-family house whose energy balance over one year of operation. In particular when the air temperature is close to the melting temperature 22°C. A global building model consisting of a building envelope modeled and simulated in TRNSYS and EnergyPlus and the modeled exchanger Mechanic solar ventilation air/PCM fan system is simulated under climate (CASABLANCA NOUSSEUR). The energy consumption related to the specific uses of electricity is taken into account in the annual energy balance. The results show that the Mechanical solar ventilation with the phase change materials (PCM + MSV) reduces the operating temperature of the house significantly and relative humidity and maintain the demand energy from HVAC system. Indeed, the Mechanical solar ventilation has decreased its average operating temperature by about 2.7°C-3°C and created the fresh and comfort space.
Molecular Findings Among Patients for Whole Exome Sequencing and mitochondrial genome assessment
Authors: Sun Gege , Huang Wei , Wang Li , Wu Jinlin , Zhao Ganye , Ren Huanan , Liu Lina , Kong Xiangdong 
Published: September 2023

Abstract

Objective: Whole exome sequencing (WES) is increasingly used as a diagnostic tool in medicine. We report the diagnostic yield of WES and mitochondrial genome in 2226 consecutive cases at a single clinical laboratory.
Methods: We performed a retrospective analysis of consecutive WES reports of 2226 patients affected by a range of genetic disorders. The WES was performed solely for the probands and in a higher diagnostic capacity. We determined the diagnostic rate of WES overall as well as by phenotypic category, mode of inheritance, mitochondrial genome variant, and copy number variants (CNVs).
Results: Of 2226 individuals having diagnostic WES proband-only, the overall diagnostic yield of WES was 34.59%. autosomal dominant (45.58%), followed by autosomal recessive (31.95%), X-linked (9.61%), and mitochondrial (0.65%), The remaining diagnoses were based on a total of 94 copy number variants (12.21%) reported from WES data. The CNV variation in children accounted for 67.02% of the total CNV variation. Molecular diagnoses were reported for 31.14% (373/1198) of adults, lower than a primarily pediatric population (38.62%, 397/1028). A While the majority of molecular diagnoses were related to nuclear genes, mitochondrial genome sequencing included in the WES test yielded five diagnoses, and all confirmed mitochondrial diseases were detected in adults. The highest positivity rate was observed in children aged 1-4 years old (43.72%, 80/183). Patients with integument system disorders had the highest diagnostic yield (58.33%, 59/151). The endocrine and metabolic disorders were the most common systems in both adults and children (261, 217). However, in adults, the highest diagnosis rate was for integument system disorders (71.43%, 30/42), while in children, the highest diagnosis rate was for disorders involving hearing (61.73%, 50/81). In addition to cases with a definitive diagnosis, in 8.4% of cases a candidate gene was reported that may later be reclassified as being associated with a definitive diagnosis.
Conclusions: WES proband-only provided a definitive molecular diagnosis for 34.59% of a large cohort of patients referred for evaluation for evaluation of suspected genetic conditions, that analysis of WES simultaneously analyze the SNVs, Exons, mitochondrial genome and CNVs significantly improves the diagnostic yield compared with WES single detection method, and facilitates identification of novel candidate genes. The yield of whole exome sequencing in this study may have advantages over reported molecular diagnostic methods.
Choroidal vascularity features of fundus tessellation in adults with high myopia
Authors: Zhang Rongrong , Xue Jiarui , Zheng Minmin , Cao Xiao , Li Chenhao , Wu Changfan 
Published: September 2023

Abstract

Background
To investigate alterations in choroidal vascularity among highly myopic adults with fundus tessellation, utilizing optical coherence tomography.
Methods
Total of 143 highly myopic adults (234 eyes) with fundus tessellation were collected in this retrospective study, which was stratified into different lesion groups based on the novel tessellated classification. Subfoveal choroidal thickness (SFCT), luminal area (LA), stromal area (SA), total choroidal area (TCA), and choroidal vascularity index (CVI) were analyzed utilizing optical coherence tomography (OCT) with enhanced depth imaging (EDI) mode, enabling precise quantification of these parameters.
Results
Comparison analysis demonstrated notable distinctions in spherical equivalent (SE), axial length (AL), and SFCT across the four tessellated grades (p < 0.001). Considerations of the choroidal vascularity parameters, LA, TCA, CVI were significant differences among the four groups (p < 0.001), while no significant variations were observed in SA when comparing Grade 1 versus Grade 2, as well as Grade 2 versus Grade 3 (p > 0.05). Logistic regression analyses illustrated that the higher grade of tessellated exhibited a positive association with AL (OR = 1.701, p = 0.027), while negatively associated with SFCT (OR = 0.416, p = 0.007), LA (OR = 0.438, p = 0.010) and CVI (OR = 0.529, p = 0.004). Multiple regression analyses demonstrated a significant negative association between CVI and both SE and AL after adjusting for age, while positively associated with SFCT (p < 0.05).
Conclusion
Subtle choroidal vascularity changes may have a meaningful contribution to the development and progression of fundus tessellation. CVI and LA were dramatically decreased during the early tessellation development and maintained relatively stable status when developing into severity tessellated grades.