bluuebunny/crossref_metadata_2025_split huggingface dataset:
Kebiasaan merokok dan konsumsi garam berlebihan terhadap kejadian hipertensi pada lansia
Authors: Kamaruddin Ilham , Sulami Neti , Muntasir Muntasir , Zulkifli Zulkifli , Marpaung Mauritz Pandapotan 
Published: May 2023

Background: Hypertension is one of the non-communicable diseases that many people of productive age and the elderly suffer from today. The increase in the prevalence of hypertension is influenced by lifestyle, one of which is smoking and excessive salt consumption.Purpose: To determine the smoking habits and excessive salt consumption on hypertension occurrence among the elderly.Method: A cross-sectional research design with a population was the elderly who lived in the working area of the Mangger Health Centre. The number of samples in this study was 91 elderly. The sampling technique used is purposive sampling. The instrument used is a questionnaire. Data analysis using chi-square test.Results: Finding that there was an influence between smoking behavior on the incidence of hypertension in the elderly (0.040<0.05) and OR = 2.663. there is an influence between excessive salt consumption on the incidence of hypertension in the elderly (0.001<0.05) and OR= 4.948Conclusion: The elderly who smoke are 2.6 times more likely to suffer from hypertension compared to the elderly who do not smoke and the elderly who consume excess salt is 5 times more likely to suffer from hypertension compared to the elderly who do not consume excess saltSuggestion: Health workers to provide education to the public about efforts to prevent hypertension by improving lifestyle.Keywords: Smoking habits; Excessive salt consumption; Hypertension; Elderly.Pendahuluan: Hipertensi merupakan salah satu penyakit tidak menular yang banyak diderita oleh masyarakat usia produktif dan lansia saat ini. Peningkatan prevalensi hipertensi dipengaruhi oleh gaya hidup salah satunya adalah merokok dan konsumsi garam berlebih.Tujuan: Mengetahui pengaruh kebiasaan merokok dan konsumsi garam berlebihan terhadap kejadian hipertensi pada lansiaMetode: Penelitian cross sectional dengan populasinya lansia yang tinggal di wilayah kerja Puskesmas Mangger dan jumlah sampelnya sebanyak 91 lansia. Teknik sampel yang digunakan adalah purposive sampling. Instrumen yang digunakan adalah kuesioner. Analisis data menggunakan uji chi square.Hasil: Didapatkan adanya pengaruh antara perilaku merokok terhadap kejadian hipertensi pada lansia (0,040<0,05) dan OR=2,663. Ada pengaruh antara konsumsi garam berlebihan terhadap kejadian hipertensi pada lansia (0,001<0,05) dan OR= 4,948.Simpulan: Lansia yang merokok berpeluang 2,6 kali menderita hipertensi dibandingkan dengan lansia yang tidak merokok dan lansia yang mengkonsumsi garam berlebih berpeluang 5 kali menderita hipertensi dibandingkan dengan lansia yang tidak konsumsi garam berlebih.Saran: Disarankan kepada tenaga kesehatan untuk memberikan edukasi kepada masyarakat tentang upaya pencegahan hipertensi dengan memperbaiki gaya hidup.
Amino acid modified OCMC-g-Suc-β-CD nanohydrogels carrying lapatinib and ginsenoside Rg1 exhibit high anticancer activity in a zebrafish model
Authors: Cui Li , Liu Xiaolan , Yan Rongjun , Chen Qixu , Wang Lizhen , Nawaz Shah , Qin Dawei , Wang Daijie 
Published: May 2023

Nanohydrogels show great potential as efficient drug carriers due to their biocompatibility, low toxicity, and high water absorbability. In this paper, we prepared two O-carboxymethylated chitosan (OCMC)-based polymers functionalized with β-cyclodextrin (β-CD) and amino acid. The structures of the polymers were characterized by Fourier Transform Infrared (FTIR) Spectroscopy. Morphological study was carried out on a Transmission Electron Microscope (TEM), and the results indicated that the two polymers had irregular spheroidal structure with some pores distributed on their surface. The average particle diameter was below 500 nm, and the zeta potential was above +30 mV. The two polymers were further used for preparing nanohydrogels loaded with anticancer drugs lapatinib and ginsenoside Rg1, and the resulting nanohydrogels showed high drug loading efficiency and pH-sensitive (pH = 4.5) drug release behavior. In vitro cytotoxicity investigation revealed that the nanohydrogels exhibited high cytotoxicity against lung cancer (A549) cells. In vivo anticancer investigation was performed in a transgenic Tg(fabp10:rtTA2s-M2; TRE2:EGFP-krasV12) zebrafish model. The results showed that the synthesized nanohydrogels significantly inhibited the expression of EGFP-krasv12 oncogene in zebrafish liver, and the L-arginine modified OCMC-g-Suc-β-CD nanohydrogels loading lapatinib and ginsenoside Rg1 showed the best results.
Scientific debate on human migration: ethics, challenges, and solutions
Authors: Yen Peter Tsung-Wen , Cheong Siew Ann 
Published: May 2023

Introduction:In recent years, we witnessed increasing numbers of migrants worldwide owing to famine, poverty, regional conflicts,etc.Efforts by the United Nations and various organizations to help these migrants are hampered by rising anti-migrant sentiments and xenophobic rhetoric in many parts of the world. To arrive at win-win solutions that benefit both natives and migrants, we must discuss the migration problem objectively and scientifically. To do this, we must first resolve the paradox in our understanding of human migration (widely touted as good) vis-a-vis biological invasion (generally regarded as bad).Method:Suspecting that the two similar phenomena are more complex than we think, we reviewed and synthesized the disjoint literatures on human migration and biological invasion in recent times, and that on the human diaspora and human-aided dispersal of plants and animals in our pre-historic past. We then developed models of niche-niche interactions to simulate isolated ecosystems and communities, as well as those experiencing invasions from non-native populations.Results:In this paper, we simulated four invasion mechanisms on a star network: the direct introduction of a non-native population into existing periphery or core niches, or the non-native population first creating its own niche, which is thereafter attached to the periphery or core of the community. We found that periphery invasions can fail, i.e., the non-native population eventually disappears. When periphery invasion is successful, we found that there is little or no harm to the ecosystem or community. On the other hand, core invasion is always catastrophic, where the non-native population establishes itself at the expense of most or all of the native populations. For niche attachments, whether to the periphery or to the core, we found native and non-native populations coexisting in the end, sometimes with increased diversities.Discussion:Our results provide promising new insights and theoretical grounds for policymakers to discuss the ethics of immigration issues scientifically, and to ultimately discover win-win solutions for natives and migrants. The theoretical framework outlined in this paper can also be applied to the problem of introducing non-native biological species for economic gains, at acceptable ecological costs.
Family functioning and resilience in children in mainland China: life satisfaction as a mediator
Authors: Dou Diya , Shek Daniel T. L. , Tan Lindan , Zhao Li 
Published: May 2023

IntroductionGrounded in the perspective of “Positive Youth Development” (PYD), resilience is an important developmental asset shaping human development. Although many studies have examined the impact of resilience on child developmental outcomes, relatively few studies have focused on the predictors of resilience, in particular familial antecedents of resilience in Chinese children and adolescents. In addition, the degree to which life satisfaction contributes to the mechanism by which family functioning impacts the development of children’s resilience over time needs to be clarified. Besides, there is a scarcity of studies that incorporate family functioning, resilience as well as life satisfaction in a single comprehensive investigation to analyze the mediating impact of life satisfaction on the linkage between family functioning and resilience under COVID-19.MethodsThe study investigated the predictive role of family functioning on resilience as well as the mediating effect of life satisfaction within the context of COVID-19, using data gathered in two waves before the onset of the pandemic and after the resumption of school during the pandemic, with 6 months apart. We employed the 33-item “Chinese Family Assessment Instrument” to evaluate family functioning, the 7-item “Chinese Resilience Scale” to assess resilience, and the “Satisfaction with Life Scale” with 5 items to measure life satisfaction.ResultsAs per the responses of 4,783 students in Grades 4 through 7 recruited in Sichuan, China, family functioning significantly predicted resilience concurrently and longitudinally. After controlling for resilience scores in Wave 1, results demonstrated that family functioning examined in Wave 1 predicted an increase in resilience reported in Wave 2. In addition, family functioning significantly predicted life satisfaction, which also significantly predicted resilience. Multiple regression using PROCESS analyses indicated that life satisfaction mediated the predictive relationship between family functioning and child resilience.DiscussionThe findings spotlight the significant involvement of family functioning as well as life satisfaction in shaping children’s resilience in the Chinese context. The study also supports the hypothesis that perceived satisfaction with life serves as a mediator between family functioning and child resilience, suggesting interventions and support should concentrate on the family level for enhancing resilience in children.
Persistence of Campylobacter spp. in Poultry Flocks after Disinfection, Virulence, and Antimicrobial Resistance Traits of Recovered Isolates
Authors: Gharbi Manel , Béjaoui Awatef , Hamrouni Safa , Arfaoui Amel , Maaroufi Abderrazak 
Published: May 2023

To investigate the persistence risk of Campylobacter spp. in poultry farms, and to study the virulence and antimicrobial resistance characteristics in the recovered strains, we collected 362 samples from breeding hen flocks, before and after disinfection. The virulence factors were investigated by targeting the genes; flaA, cadF, racR, virB11, pldA, dnaJ, cdtA, cdtB, cdtC, ciaB, wlaN, cgtB, and ceuE by PCR. Antimicrobial susceptibility was tested and genes encoding antibiotic resistance were investigated by PCR and MAMA-PCR. Among the analyzed samples, 167 (46.13%) were positive for Campylobacter. They were detected in 38.7% (38/98) and 3% (3/98) of environment samples before and after disinfection, respectively, and in 126 (75.9%) out of 166 feces samples. In total, 78 C. jejuni and 89 C. coli isolates were identified and further studied. All isolates were resistant to macrolids, tetracycline, quinolones, and chloramphenicol. However, lower rates were observed for beta-lactams [ampicillin (62.87%), amoxicillin-clavulanic acid (47.3%)] and gentamicin (0.6%). The tet(O) and the cmeB genes were detected in 90% of resistant isolates. The blaOXA-61 gene and the specific mutations in the 23S rRNA were detected in 87% and 73.5% of isolates, respectively. The A2075G and the Thr-86-Ile mutations were detected in 85% and 73.5% of macrolide and quinolone-resistant isolates, respectively. All isolates carried the flaA, cadF, CiaB, cdtA, cdtB, and cdtC genes. The virB11, pldA, and racR genes were frequent in both C. jejuni (89%, 89%, and 90%, respectively) and C. coli (89%, 84%, and 90%). Our findings highlight the high occurrence of Campylobacter strains exhibiting antimicrobial resistance with potential virulence traits in the avian environment. Thus, the improvement of biosecurity measures in poultry farms is essential to control bacterial infection persistence and to prevent the spread of virulent and resistant strains.
The Influence of Pichia kluyveri Addition on the Aroma Profile of a Kombucha Tea Fermentation
Authors: van Wyk Niël , Binder Julia , Ludszuweit Marie , Köhler Sarah , Brezina Silvia , Semmler Heike , Pretorius Isak S. , Rauhut Doris , Senz Martin , von Wallbrunn Christian 
Published: May 2023

Traditional kombucha is a functional tea-based drink that has gained attention as a low or non-alcoholic beverage. The fermentation is conducted by a community of different microorganisms, collectively called SCOBY (Symbiotic Culture of Bacteria and Yeast) and typically consists of different acetic acid bacteria and fermenting yeast, and in some cases lactic acid bacteria that would convert the sugars into organic acids—mostly acetic acid. In this study, the effect of including a Pichia kluyveri starter culture in a kombucha fermentation was investigated. P. kluyveri additions led to a quicker accumulation of acetic acid along with the production of several acetate esters including isoamyl acetate and 2-phenethyl acetate. A subsequent tasting also noted a significant increase in the fruitiness of the kombucha. The significant contribution to the aroma content shows the promise of this yeast in future microbial formulations for kombucha fermentations.
GENETIC STRUCTURE OF THE AIRSHIERE CATTLE SUBPOPULATION IN THE SOUTHERN REGIONS OF RUSSIA BY MICROSATELLITE LOCUS
Authors: КОВАЛЮК Н.В. , ЯКУШЕВА Л.И. , ШАХНАЗАРОВА Ю.Ю. , ВОЛЧЕНКО А.Е. 
Published: May 2023

Изучена генетическая структура субпопуляции айрширской породы крупного рогатого скота (n=600) в ряде хозяйств Краснодарского и Ставропольского краев по микросателлитным локусам: BM1818, BM1824, BM2113, ETH10, ETH225, ETH3, INRA023, SPS115, TGLA126, TGLA122, TGLA227, TGLA53. Определены количество гомозиготных и гетерозиготных животных по обозначенным выше локусам, наблюдаемая и ожидаемая гетерозиготность, индекс фиксации (Fis), породоспецифичные и часто встречающиеся аллели. В исследуемой выборке айрширского скота в среднем наблюдался минимальный излишек гетерозигот (Fis=-0,03). Установлено, что уникальными для представленной выборки айрширской породы являются аллели: 184 (локус BM1824) — с частотой встречаемости 5,0%, 77 (TGLA227) — с частотой встречаемости 2,0%, 180 (TGLA53) — с частотой встречаемости 0,3%, 222 (INRA023) — с частотой встречаемости 0,5%. У животных айрширской породы выявлен аллельный вариант, который не обнаружен у джерсеев, но достаточно часто в 15,7% случаев определялся у голштинов (локус ETH3 — аллель 127), и в 13,3% — у айрширов. С самой высокой частотой (58,4%) в группе животных айрширской породы выявлен аллель 115 локуса TGLA126. Полученные профили можно использовать в популяционных исследованиях и в практической работе по отнесению тех или иных групп скота к айрширской породе.
The genetic structure of the subpopulation of the Ayrshire breed of cattle (n=600) was studied in a number of farms in the Krasnodar and Stavropol Territories by microsatellite loci: BM1818, BM1824, BM2113, ETH10, ETH225, ETH3, INRA023, SPS115, TGLA126, TGLA122, TGLA227, TGLA23. The number of homozygous and heterozygous animals according to the above loci, observed and expected heterozygosity, fixation index (Fis), breed-specific and frequently occurring alleles were determined. In the studied sample of Ayrshire cattle, on average, there was a minimal excess of heterozygotes (Fis=-0.03). It was established that alleles unique for the presented sample of the Ayrshire breed are: 184 (locus BM1824) - with a frequency of occurrence of 5.0%, 77 (TGLA227) — with a frequency of occurrence of 2.0%, 180 (TGLA53) — with a frequency of occurrence of 0.3 %, 222 (INRA023) with a frequency of 0.5%. In animals of the Ayrshire breed, an allelic variant was identified that was not found in Jerseys, but quite often in 15.7% of cases it was determined in Holsteins (the ETH3 locus is allele 127), and in 13.3% in Ayrshires. Allele 115 of the TGLA126 locus was identified with the highest frequency (58.4%) in the group of Ayrshire breed animals. The profiles obtained can be used in population studies and in practical work on assigning certain groups of cattle to the Ayrshire breed.
Analisis dan Penerapan Algoritma Apriori Pada Penempatan Barang Pada Toko Surya Desa Pudak
Authors: Ariyanti  , Jasmir  , Rianti Silvia 
Published: May 2023

Dunia bisnis pada saat ini berkembang sangat cepat, khususnya di dunia perdagangan. Persaingan dalam dunia bisnis selalu ada, sehingga setiap orang yang berkegiatan bisnis dituntut untuk selalu bisa memikirkan dengan cara efektif dan efisien dalam pengembangan bisnis tersebut. Salah satu bentuk usaha bisnis, Toko Surya Desa Pudak yang beralamat di Jalan Jambi-Suak Kandis Km.7 Desa Pudak Muaro Jambi, merupakan sebuah toko yang menjual kebutuhan pokok dan peralatan lainnya yang ditempatkan di sebuah rak atau etalase. Banyak kejadian pembeli yang ingin belanja masih bertanya kepada karyawan dimana posisi barang yang ingin dibeli. Maka dari itu dengan menggunakan Algoritma Apriori, toko diharapkan dapat menentukan strategi dalam menentukan pembelian barang sesuai ketersediaan barang yang dibutuhkan konsumen sehingga bisa mengatur posisi barang berdasarkan gabungan item set barang. Jadi barang yang sering dibeli oleh konsumen yaitu Mie, Roti, odol dan Sirup support 30% dan confidence 100% diketahui barang yang sering dibeli konsumen.
Implementasi Data Mining Untuk Penjualan Mobil Menggunakan Metode Naive Bayes
Authors: Rifky Luthfi , Nugraha Zahlan , Saputra Bayu , Pratama Dimas , Raswir Errissya , Pratama Yovi 
Published: May 2023

Abstrak- Mobil adalah salah satu kendaraan yang paling sering dijumpai dengan berbagai type dan merek. Mobil memiliki spesifikasi yang beraneka ragam. Metode Naive Bayes adalah salah satu metode klasifikasi dan percabangan dari artificial intellegence. Bermacam merek tersebut akan dibentuk suatu Classify yaitu Laris dan Tidak Laris, sehingga para konsumen, produsen, dan peneliti dapat mengetahui merek mobil manakah yang paling laris berdasarkan kategori maupun output-nya. Naive bayes merupakan metode klasifikasi yang banyak digunakan karena sederhana dan akurasi yang tinggi dalam mengklasifikasi data. Penelitian ini menganalisis data sebanyak 639 data menjadi 511 data training dan 128 data testing, data ini didapatkan dari situs “Gabungan Industri Kendaraan Bermotor Indonesia”(GAIKINDO). Dengan atribut 19, untuk memudahkan penulis dalam penelitian, maka atribut yang digunakan adalah 8 (termasuk 1 atribut Classify yang ditambahkan penulis untuk memudahkan dalam pencarian mobil terlaris). Hasil penelitian yang dilakukan memberikan klasifikasi pembeda merek mobil yang paling banyak diminati para konsumen dan Kategori yang paling laris. Tingkat akurasi klasifikasi dengan Metode Naive Bayes menghasilkan nilai accuracy sebesar 92,19%, nilai Precision: 98,39% dan nilai Recall: 87,14% sehingga Metode Naive Bayes merupakan metode yang cukup baik dalam penelitian ini.
Kata kunci: Brand Mobil, Klasifikasi, Naive Bayes, Accuracy
Abstract- Cars are one of the vehicles most often found in various types and brands. Carshave various specifications. The Naive Bayes method is one of the classification and branching methods of artificial intelligence. The various brands will be in theform of a Class that are Selling and Not Selling, so that consumers, producers, and researchers can find out which car brands are best selling based on their category and output. Naive bayes is a widely used classification method because of its simple and high accuracy in classifying data. This study analyzed data as many as 639 data into 511 training data and 128 testing data, data was obtained from “the Indonesian Automotive Industries Association” (IAIS) site. With attribute 19, tofacilitate the writer in the study the attributes used were 8 (including 1 Class attribute that author added to facilitate the search for the best-selling car). Theresults of the conducted research gave the classification of car brand different that were most in demand by consumers and the best-selling categories. The level of classification accuracy with the Naive Bayes Method produces accuracy valuesof 92, 19%, Precision values: 98, 39% and Recall values: 87, 14% so that the Naive Bayes Method is a pretty good method in this research.
Keywords: Car Brand, Classification, Naive bayes, Accuracy
Perancangan Sistem Informasi Persediaan Obat Berbasis Web Pada Apotek Rahayu Farma, Muaro Jambi
Authors: Abdurrahman  , Rohaini Eni , Errissya Rasywir  
Published: May 2023

APOTEK RAHAYU FARMA Muaro Jambi Apotek merupakan suatu tempat pelayanan produk maupun jasa kefarmasian (obat-obatan) kepada masyarakat yang berada di Muaro Jambi. Pengelolaan Apotek adalah segala upaya dan kegiatan yang dilakukan oleh seorang Apoteker Pengelola Apotek dalam rangka tugas dan fungsi apotek yang meliputi perencanaan, pengorganisasian, pelaksanaan, pengawasan dan penilaian. Apotek memiliki data-data transaksi penyaluran sediaan farmasi khususnya obat yang sangat banyak terutama apotek yang berada pada rumah sakit. Namun pencatatan data-data yang masih menggunakan buku menyebabkan pencatatan data jadi tidak akurat. Selain itu juga masalah bila akan melihat stok yang ada harus mencari satu persatu dalam kartu stok obat. Tidak adanya kerahasiaan dalam sistem inventory yang ada karena dapat di akses oleh siapapun. Maka bila data-data ini sampai ditangani oleh pihak yang tidak bertanggung jawab bisa berakibat tidak baik pada apotek. Kurang cepatnya dalam menangani sistem inventory obat karena harus mencari kartu stok yang ada di kartu stok obat tersebut. Sistem akan dibangun berbasis website dengan menggunakan bahasa pemrograman PHP. Terbangunnya Sistem Informasi Persediaan Obat Berbasis Web Pada Apotek Rahayu Farma, dapat membantu petugas apotek dalam melakukan pendataan obat keluar dan masuk kedalam apotek serta akan mempermudah pencarian stok obat.
Kata Kunci: Kata Kunci : Perancangan, Sistem Informasi Persediaan, Web
Klasifikasi Kelayakan Keluarga Penerima Bantuan Langsung Tunai Menggunakan Gain Ratio Dan Naïve Bayes
Authors: Sandi Shelby Amalia , Kurniabudi  , Novianto Yudi 
Published: May 2023

Indonesia termasuk salah satu negara berkembang yang menghadapi kemiskinan khususnya didaerah kecil seperti Kelurahan Talang Babat yang terletak di Kabupaten Tanjung Jabung Timur Provinsi Jambi, penyebab terjadinya kemiskinan yaitu data warga penerima Bantuan Langsung Tunai tidak akurat dan tidak tepat sasaran.Hal ini dapat menimbulkan keluhan masyarakat, dan ketidakpuasan terhadap petugas kelurahan. Salah satu aspek penting yang mendukung strategi penanggulangan kemiskinan adalah dengan tersedianya data warga penerima Bantuan Langsung Tunai (BLT) yang akurat dan tepat sasaran. Oleh karena itu dibutuhkan metode untuk megelompokkan data penerima BLT, agar pemberian BLT tepat sasaran. Pada penelitian ini algoritma Naïve Bayes diimplementasikan dan dianalisis menggunakan evaluasi 3 options dengan Rapid miner sebagai alat bantu penelitian. Dari hasil evaluasi menggunakan 3 options test yaitu Use training set, 5 Fold Cross-Validation dan 10 Fold Cross-Validation, didapatkan persentase nilai tertinggi pada pengujian Use training set yang akurasinya sebesar 90,60%, presisi 96,67%, dan recall 92,06%.