bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring the Potential of ω3 Derivatives as Tyrosinase Inhibitors: A Comprehensive Study Combining Experimental, Computational, and Biological Approaches
Authors: Sanginabadi Farhad , Gheibi Nematollah , Divsalar Adeleh , Saboury Ali Akbar , Yaghmaei Parichehreh , Sadeghi Morteza 
Published: June 2023

AbstractIn this work, the inhibitory ability and mechanism of ω3‐nicotinic acid (ω3‐NA) and ω3‐Picolinic acid (ω3‐PA) complexes on the activity of mushroom tyrosinase (MT) were scrutinized for progressing a novel MT inhibitor. The complexes were synthesized. It was shown to have a considerable inhibition on the MT activity and Ki value of ω3‐NA and ω3‐PA on MT equal to 5.2 and 5.1 mM, respectively. ω3‐NA and ω3‐PA inhibited MT with Vmax values in the range of 0.134 mM and 0.14 mM, respectively. The outputs obtained from fluorescence quenching specified that ω3‐NA and ω3‐PA could interact with MT. Especially, the decrease in fluorescence intensity was due to the formation of a ligand‐enzyme complex which was mostly motivated by hydrogen bonding and hydrophobic forces. The presence of ω3‐NA and ω3‐PA altered the structure of MT and reduced the α‐helix of the enzyme. Molecular docking investigation along with molecular dynamics simulation exhibited that ligands‐MT formation is directed by hydrogen binding with Trp136, His263, and Val299 residues. The results highlight that ω3‐NA and ω3‐PA can be considered as possible inhibitors in treating hyperpigmentation via MT enzyme inhibition.
Visible‐Light Mediated Metal‐free Synthesis of 3‐Bromo Coumarins Using In situ Generated Transient Non‐Symmetric Bromoiodanes
Authors: Monika  , Ram Bajya Kalu , Gupta Manoj K. , Selvakumar Sermadurai 
Published: June 2023

AbstractWe report herein the in situ generated transient non‐symmetric bromoiodanes promoted regioselective intramolecular halocyclization of alkynoates for the first time under visible light irradiation enables the formation of 4‐aryl‐3‐bromocoumarin derivatives. Using this protocol, a broad range of valuable brominated coumarins can be synthesized in moderate to excellent yield using simple household CFL bulb as light source under photocatalyst free condition. In addition, preliminary control studies were conducted to gain more insights to propose the plausible reaction mechanism.
Functionalized Diazabenzo[a]anthracenediones: Regioselective Multicomponent Synthesis and Biological and Computational Studies as Potential Cholinesterase Inhibitors
Authors: Tariq Riaz Muhammad , Taslimi Parham , Yaqub Muhammad , al‐Rashida Mariya , Alharthy Rima D. , El‐Gokha Ahmed , Shafiq Zahid 
Published: June 2023

AbstractHeterocyclic ketene aminals (HKAs) have been used to synthesize diaza‐benzo[a]anthracenedione derivatives through highly efficient one pot three‐component cascade reaction from readily available precursors. 2‐Hydroxy‐1,4‐naphthoquinone (HNQ) and aromatic aldehydes are reacted with heterocyclic ketene aminals via Et3N‐catalyzed tandem [3+2+1] annulation under solvent‐free conditions. These reactions were very smooth, productive with high yield and highly regioselective for the synthesis of novel fused tetracyclic compounds (4 a–4 i). These synthesized compounds were discovered to be potent inhibitors of the acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes, with Ki values for BChE ranging from 27.37±4.70 to 78.06±6.96 nM and AChE from 59.01±6.91 to 150.88±14.84 nM, respectively. Molecular docking studies was carried out to find the interactions of most potent inhibitors.
Cyclohexane based Bis‐imine and Salicylic Acid Derived Tripodal Amide for Optical Recognition and Enrichment of Sm3+ and Dy3+
Authors: Shyam Tandrim , Changdar Sutapa , Das Debasis 
Published: June 2023

AbstractSingle crystal X‐ray structurally characterized bis‐imine derivative (P1) selectively recognizes Sm3+ in DMSO‐water (1 : 6, v/v) media. On the other hand, salicylic acid derived tripodal amide (P2) efficiently detects Sm3+ and Dy3+ in DMSO‐water (1 : 5, v/ v) media. In both cases, Sm3+ emits intense pink light while Dy3+ emits yellow light. The P1 experiences 42‐fold fluorescence enhancement in presence of Sm3+. The P2 experiences 36‐fold and 23‐fold fluorescence enhancement in presence of Sm3+ and Dy3+ respectively. The limit of detections (LODs) for Sm3+ are 9.2×10−8 M (by P1) and 1.04×10−7 M (by P2) while it is 9.67×10−7 M for Dy3+ (by P2). The P1 assisted enrichment of Sm3+ is encouraging.
Synthesis and Potential Dual Inhibitory Activity Against Acetylcholinesterase and Butyrylcholinesterase of Galactose‐Conjugated Isatin β‐Thiosemicarbazones
Authors: Thanh Nguyen Dinh , Giang Nguyen Thi Kim , Toan Vu Ngoc , Van Hoang Thi Kim , Tri Nguyen Minh , Anh Hoang Huu , Hai Do Son 
Published: June 2023

AbstractA series of different isatin‐thiosemicarbazones 4 a–4 t derived from corresponding substituted isatins and N‐(2,3,4,6‐tetra‐O‐acetyl‐β‐d‐galactopyranosyl)thiosemicarbazide had been synthesized. Their anti‐Alzheimer activity were studied through the inhibitions of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Most of these compounds exhibited inhibitory activities against these enzymes. Of these isatin N‐(2,3,4,6‐tetra‐O‐acetyl‐β‐d‐galactoranosyl)thiosemicarbazones 4 a–4 t, in IC50 range below 0.05 μM, some thiosemicarbazones exhibited potent inhibitory activity against AChE enzyme, including 4 s (1‐benzyl)>4 t (1‐phenthyl)>4 p (1‐allyl)>4 r (1‐t‐butyl), and others exhibited potent inhibitory activity against BChE, including 4 t (1‐phenthyl)>4 o (1‐propyl)>4 q (1‐butyl)> 4 s (1‐benzyl). Enzymic kinetics of AChE and BChE inhibition of 4 s and 4 t, were studied. These compounds with strong inhibitory activity had been further investigated in induced fit docking studies as well as molecular dynamics simulations. The obtained resulting simulations indicate that strong ligand‐residues interactions were decisive factors to inhibitory activity of 4 s and 4 t against AChE and BChE enzymes, respectively.
Liquid‐in‐Aerogel Porous Composite Allows Efficient CO2 Capture and CO2/N2 Separation
Authors: Jiang Haotian , Hou Yinglai , Liu Zengwei , Yuan Ruizhe , Du Yu , Ji Xiaofei , Sheng Zhizhi , Zhang Xuetong 
Published: June 2023

AbstractThe pursuit of efficient CO2 capture materials remains an unmet challenge. Especially, meeting both high sorption capacity and fast uptake kinetics is an ongoing effort in the development of CO2 sorbents. Here, a strategy to exploit liquid‐in‐aerogel porous composites (LIAPCs) that allow for highly effective CO2 capture and selective CO2/N2 separation, is reported. Interestingly, the functional liquid tetraethylenepentamine (TEPA) is partially filled into the air pockets of SiO2 aerogel with left permanent porosity. Notably, the confined liquid thickness is 10.9–19.5 nm, which can be vividly probed by the atomic force microscope and rationalized by tailoring the liquid composition and amount. LIAPCs achieve high affinity between the functional liquid and solid porous counterpart, good structure integrity, and robust thermal stability. LIAPCs exhibit superb CO2 uptake capacity (5.44 mmol g−1, 75 °C, and 15 vol% CO2), fast sorption kinetics, and high amine efficiency. Furthermore, LIAPCs ensure long‐term adsorption–desorption cycle stability and offer exceptional CO2/N2 selectivity both in dry and humid conditions, with a separation factor up to 1182.68 at a humidity of 1%. This approach offers the prospect of efficient CO2 capture and gas separation, shedding light on new possibilities to make the next‐generation sorption materials for CO2 utilization.
Quasi‐2D Lead–Tin Perovskite Memory Devices Fabricated by Blade Coating
Authors: Chen Lijun , Xi Jun , Tekelenburg Eelco Kinsa , Tran Karolina , Portale Giuseppe , Brabec Christoph J , Loi Maria Antonietta 
Published: June 2023

AbstractTwo terminal passive devices are regarded as one of the promising candidates to solve the processor‐memory bottleneck in the Von Neumann computing architectures. Many different materials are used to fabricate memory devices, which have the potential to act as synapses in future neuromorphic electronics. Metal halide perovskites are attractive for memory devices as they display high density of defects with a low migration barrier. However, to become promising for a future neuromorphic technology, attention should be paid on non‐toxic materials and scalable deposition processes. Herein, it is reported for the first time the successful fabrication of resistive memory devices using quasi‐2D tin–lead perovskite of composition (BA)2MA4(Pb0.5Sn0.5)5I16 by blade coating. The devices show typical memory characteristics with excellent endurance (2000 cycles), retention (105 s), and storage stability (3 months). Importantly, the memory devices successfully emulate synaptic behaviors such as spike‐timing‐dependent plasticity, paired‐pulse facilitation, short‐term potentiation, and long‐term potentiation. A mix of slow (ionic) transport and fast (electronic) transport (charge trapping and de‐trapping) is proven to be responsible for the observed resistive switching behavior.
Influence of abiotic and biotic factors on benthic marine community composition, structure and stability: a multidisciplinary approach to molluscan assemblages from the Miocene of northern Germany
Authors: Carobene Daria , Bussert Robert , Struck Ulrich , Reddin Carl J. , Aberhan Martin 
Published: June 2023

AbstractThe Miocene mica‐clay deposits of Groß Pampau (northern Germany) are well known for their diverse assemblages of marine mammals. Despite numerous systematic and biostratigraphic studies, an in‐depth palaeoecological analysis of its molluscan assemblages and a comprehensive palaeoenvironmental reconstruction are lacking. Here, we integrate new faunal, sedimentological and geochemical data to reconstruct the marine palaeoecosystem of the Upper Miocene sedimentary succession of Groß Pampau, and to identify the drivers controlling the composition, ecological structure and temporal dynamics of its macrobenthic molluscan assemblages. Fossil evidence, coupled with analyses of clay mineral composition, grain size distribution and geochemical data (total organic carbon, total nitrogen, δ13C, δ18O, δ15N of sediment and shells), suggests a warm–temperate, mesotrophic, low‐energy, offshore marine setting mostly below storm wave base and a pronounced surface‐to‐bottom water temperature gradient. Low variability in sedimentological and geochemical signals indicates generally stable physicochemical conditions, whereas the occurrence of the opportunistic species Varicorbula gibba suggests occasionally unfavourable bottom conditions, possibly related to transient hypoxia. Canonical correspondence analysis indicates that the distribution of molluscan assemblages correlates with total organic carbon and nitrogen content, suggesting organic matter availability at the sea floor as a controlling factor. A pattern of repetitive punctuated stasis of molluscan assemblages is defined by the temporal persistence in taxonomic and ecological composition, occasionally interrupted by shifts to a different faunal configuration. We suggest that both stable environmental conditions and biotic interactions (i.e. the top‐down control exerted by carnivorous gastropods and environmental modification by ubiquitous burrowing deposit feeders) probably contributed to the observed temporal stability.
Fast surface floating organic droplets based dispersive liquid‐liquid microextraction for trace enrichment of multiclass pesticide residues from different fruit juice samples followed by high performance liquid chromatography–diode array detection analysis
Authors: Bekele Habtamu , Megersa Negussie 
Published: June 2023

AbstractThis study was designed to enable the development of a simple, fast, and environmentally friendly analytical technique utilizing dispersive liquid‐liquid microextraction based on surface floating organic droplets for selective and quantitative enrichment of trace level pesticide contaminants from different fruit juice samples for subsequent detection by high performance liquid chromatography, combined with a diode array detector. The selective extraction was necessitated in order to isolate the seven multiclass pesticide residues frequently occurring in fruit juice samples. The effects of experimental parameters such as pH of sample solution, type and volume of extraction and dispersive solvents, ionic strength and extraction time were optimized. The optimized method was validated using spiked blank sample and satisfactory results for accuracy, with recoveries ranging from 87.23% to 99.45%, with %relative standard deviation between 1.37 and 8.39, precision in terms of %relative standard deviation ≤ 10.78 and linearity at concentration levels from 3 to 1500 ng/ml, which corresponded with correlation coefficients ≥ 0.998. The limits of detection and the limits of quantification were ranged from 1.3×10−2 to 5.3×10−2 and 4.2×10−2 to 1.8×10−1 μg/L, respectively. At the end, the method was successfully applied to analyze real fruit juice samples and target analytes were not detected in real samples.
A Novel Starch‐Based Synergistic Flame Retardant for the Treatment of Insulating Paper
Authors: Chen QiJie , Liu Zhuo , Xie GuangYang , Zhao WenGuang , Chen Guang , Wang Feng 
Published: June 2023

AbstractDue to the strict working environment, insulating paper is generally required to have a good flame retardant performance. In this study, a new type of starch‐based synergistic flame retardant (SPBD) is prepared using starch as a carbon source, phytic acid, and boric acid as the acid source, and dicyandiamide as a gas source by the one‐pot method. The flammability, mechanical, and electrical properties of the flame‐retardant insulating papers treated with SPBD are also studied. When the concentration of the SPBD is 24.0%, the limiting oxygen index of the insulating paper is increased from 19.4% to 44.0% and reaches the level of UL‐94 V0. The tensile index and burst index of the flame‐retardant insulating papers are only 6.88% and 10.75% lower than that of the control insulating paper. While the ring crush strength and alternating current (AC) breakdown strength in air are 109.58% and 21.15% higher than the control insulating paper. The SPBD flame retardant has a good application prospect in insulating paper.
Seismic performance analysis and evaluation of tall structures using grille‐type steel plate composite shear walls
Authors: Yu Qiao , Wu Hao , Li Lingzhi , Ogail Emadeldin , Liu Qingyun , Zhao Xuelian , Liu Yang 
Published: June 2023

SummaryGrille‐type steel plate composite (GSPC) shear wall is an innovative wall system consisting of concrete cores, steel faceplates, steel tie plates, and steel channels with more advantages than conventional reinforced concrete (RC) walls, including better ductility, higher bearing capacity, and easy‐modular characteristics. This paper mainly discusses the seismic performance and damage resistance of GSPC walls to the entire structure from the aspect of the structural level. Three nonlinear numerical models of high‐rise structures with different structural heights and types were established by PERFORM‐3D software to study the influence of GSPC walls on the change in structural internal forces and deformations compared with RC walls. One of these structures was selected to conduct the seismic fragility analysis based on the incremental dynamic analysis and to assess the structure's seismic performance with GSPC walls. Finally, the seismic damage prediction method was used to evaluate the damage levels of the GSPC wall structure. Results indicate that the structures with GSPC walls suffer more significant seismic forces than those with RC walls, although they experience lesser structural deformations. Moreover, GSPC walls can effectively improve the structure's collapse and seismic damage resistance.
Barriers and facilitators to participating in Alzheimer's disease biomarker research in black and white older adults
Authors: Eliacin Johanne , Polsinelli Angelina J. , Epperson Francine , Gao Sujuan , Van Heiden Sarah , Westmoreland Glenda , Richards Ralph , Richards Mollie , Campbell Christopher , Hendrie Hugh , Risacher Shannon L. , Saykin Andrew J. , Wang Sophia 
Published: June 2023

AbstractIntroductionThe study examined Black and White prospective participants’ views of barriers to and facilitators of participation in Alzheimer's disease (AD) biomarker research.MethodsIn a mixed‐methods study, 399 community‐dwelling Black and White older adults (age ≥55) who had never participated in AD research completed a survey about their perceptions of AD biomarker research. Individuals from lower socioeconomic and education backgrounds and Black men were over‐sampled to address perspectives of traditionally under‐represented groups. A subset of participants (n= 29) completed qualitative interviews.ResultsMost participants expressed interest in biomarker research (overall 69%). However, Black participants were comparatively more hesitant than White participants (28.9% vs 15.1%), were more concerned about study risks (28.9% vs 15.1%), and perceived multiple barriers to participating in brain scans. These results persisted even after adjusting for trust and perceived knowledge of AD. Information was a primary barrier (when absent) and incentive (when provided) for AD biomarker research participation. Black older adults desired more information about AD (eg, risk, prevention), general research processes, and specific biomarker procedures. They also desired return of results to make informed decisions about their health, research‐sponsored community awareness events, and for researchers to mitigate the burden placed on participants in research (eg, transportation, basic needs).ConclusionOur findings increase representativeness in the literature by focusing on individuals with no history of AD research experience and those from traditionally underrepresented groups in research. Results suggest that the research community needs to improve information sharing and raising awareness, increase their presence in the communities of underrepresented groups, reduce incidental costs, and provide valuable personal health information to participants to increase interest. Specific recommendations for improving recruitment are addressed. Future studies will assess the implementation of evidence‐based, socioculturally sensitive recruitment strategies to increase enrollment of Black older adults into AD biomarker studies.HIGHLIGHTSIndividuals from under‐represented groups are interested in Alzheimer's disease (AD) biomarker research.After adjusting for trust and AD knowledge, Black participants were still more hesitant.Information is a barrier (when absent) to and incentive (when given) for biomarker studies.Reducing burden (e.g., transportation) is essential for recruiting Black older adults.
Playful mouth‐to‐mouth interactions of belugas (Delphinapterus leucas) in managed care
Authors: Ham Jackson R. , Lilley Malin K. , Wincheski Riley J. , Miranda Jesus , Velarde Dediós Ángel G. , Kolodziej Katie , Pellis Sergio M. , Manitzas Hill Heather M. 
Published: June 2023

AbstractBelugas (Delphinapterus leucas) engage in many forms of play (e.g., object, water, locomotor), but no play is quite as curious as the unusual form of cooperative social play involving mouth‐to‐mouth interactions. These playful interactions are characterized by two belugas approaching each other head‐to‐head and interlocking their jaws, clasping one another, as if they were shaking hands. Observed in belugas both in the wild and in managed care, it is seemingly an important type of social play that offers a unique way of socializing with conspecifics. To describe this unusual behavior, a group of belugas in managed care was observed from 2007 to 2019. Although adults participated in mouth‐to‐mouth interactions, most were initiated and received by young belugas. Both males and females engaged in mouth‐to‐mouth interactions and did so at similar frequencies. Individual differences in how many mouth‐to‐mouth interactions were initiated among calves were also observed. Due to the unique, cooperative nature of mouth‐to‐mouth interactions, which require both social and motor skills, it is hypothesized that these interactions may be used to test social and motor competency.
Faster, Better, Stronger
Authors: Hallonsten Olof 
Published: June 2023

AbstractInsightful sociological analyses of current society have identified acceleration as its defining feature. A competitiveness ideal, and a constant aspiration to exceed the promise of a better future with the help of technological progress, have led to a broad exploitation of vague but powerful expectations The result is often mere window-dressing, but progress has also become an identity marker for a class of politicians and business leaders who look for roles for themselves to play in the fulfillment of promises, both “moving fast and breaking things” and launching huge and very costly strategic innovation programs. The chapter analyzes these features of contemporary public and economic life and question the validity of the underlying assumptions.
Bulk reconstruction of AdSd+1 metrics and developing kinematic space
Authors: Sugiura Kakeru , Takeda Daichi 
Published: June 2023

Abstract
The metrics of the global, Poincaré, and Rindler AdSd+1 are explicitly reconstructed with given lightcone cuts. We first compute the metric up to a conformal factor with the lightcone cuts method introduced by Engelhardt and Horowitz. While a general prescription to determine the conformal factor is not known, we recover the factor by identifying the causal information surfaces from the lightcone cuts and finding that they are minimal. In addition, we propose a new type of kinematic space as the space of minimal surfaces in AdSd+1, where a metric is introduced as a generalization of the case of d = 2. This metric defines the set of bulk points, which is equivalent to that of lightcone cuts. Some other properties are also studied towards establishing a reconstruction procedure for general bulk metrics.
Einmal geimpft, immer geimpft? Routinedatenanalyse zur wiederholten Influenzaimpfung von ≥ 60-Jährigen
Authors: Storch Josephine , Meissner Franziska , Böde Monique , Kwetkat Anja , Pletz Mathias W. , Freytag Antje 
Published: June 2023

Zusammenfassung
Hintergrund
Die Ständige Impfkommission empfiehlt eine jährliche Influenzaimpfung als Standardimpfung für ≥ 60-Jährige und als altersunabhängige Indikationsimpfung. Empirische Daten zur wiederholten Impfung liegen für Deutschland nicht vor. Ziel der Studie war es daher, Häufigkeit und Einflussfaktoren der wiederholten Impfung zu untersuchen.

Methoden
Wir führten eine längsschnittliche retrospektive Beobachtungsstudie mit Routinedaten von ≥ 60‑jährigen Versicherten der Thüringer AOK Plus im Zeitraum 2012–2018 durch. Die Anzahl der Saisons mit Impfung wurde beschrieben und der Zusammenhang mit verschiedenen Versichertenmerkmalen in einem Regressionsmodell analysiert.

Ergebnisse
Es wurden 103.163 Versicherte mit mindestens einer Impfung in der Saison 2014/2015 eingeschlossen, von denen 75,3 % in ≥ 6 von 7 Saisons geimpft wurden. Häufigere Impfungen zeigten sich bei Pflegeheimbewohner:innen (Rate Ratio (RR) 1,27), Personen mit erhöhter gesundheitlicher Gefährdung infolge einer Grunderkrankung (RR 1,21) und höheren Altersgruppen (vs. 60- bis 69-Jährige: RR 1,17–1,25). Mit jedem zusätzlichen Jahr der Teilnahme an einem Disease-Management-Programm stieg die Anzahl der Impfungen (RR 1,03). Weniger häufig geimpft waren Frauen (RR 0,91), Versicherte mit Pflegestufe 1 (vs. keiner Pflegestufe: RR 0,90) und Versicherte mit einer Komorbidität (vs. keiner Komorbidität: RR 0,97).

Diskussion
Ein Großteil der einmal gegen Influenza geimpften ≥ 60-Jährigen lässt sich auch wiederholt impfen. Entsprechend den Empfehlungen sind vor allem Pflegeheimbewohner:innen und Personen mit erhöhter gesundheitlicher Gefährdung wiederholt geimpft. Hausärzt:innen kommt eine zentrale Rolle zu: Nichtakute Patientenkontakte sollten für Impfangebote genutzt werden, insbesondere bei Frauen und in der Häuslichkeit lebenden Pflegebedürftigen.