bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tratamiento de lesiones escafolunares mediante reconstrucción con plastia del extensor radial largo del carpo
Authors: Gutiérrez Miguel del Cerro , Díaz Verónica Jiménez , Lamas Lorena García , Donaire Jorge García , Osorio María Teresa Vázquez 
Published: December 2022

Resumen
Objetivo Describir la técnica quirúrgica de reconstrucción del ligamento escafolunar asistida por artroscopia empleando como donante el extensor carpi radialis longus (ECRL), un músculo que, gracias a sus propiedades biomecánicas, puede ser muy ventajoso en este tipo de cirugía.
Técnica Quirúrgica Tras artroscopia diagnóstica inicial según la técnica habitual, se llevó a cabo la reconstrucción ligamentosa empleando un hemitendón del ECRL mediante técnica mínimamente invasiva. Los dispositivos de fijación empleados fueron el SwiveLock para el escafoides y el tornillo de biotenodesis de 3 × 8 mm (Arthrex, Naples, FL, EE.UU.) para el semilunar.
Complicaciones La complicación que puede surgir durante la realización de esta técnica es la extracción dificultosa de la plastia, por la intersección entre el primer y el segundo compartimentos extensores. Es fácilmente solventable realizando una incisión intermedia a nivel de la intersección para garantizar la adecuada liberación de la plastia a esta altura.
Conclusión Es posible reconstruir el intervalo escafolunar empleando un hemitendón del ECRL, que, por propiedades biomecánicas, puede ser más ventajoso a la hora de restaurar la biomecánica del carpo. Se precisan estudios posteriores para confirmar la idoneidad y la superioridad de este donante frente a otros empleados en las técnicas de reconstrucción.
¿Cómo influyen los trastornos del estado de ánimo en el paciente con Rizartrosis?
Authors: Oteo-Maldonado Jose A. , Merino-Carretero Patricia , Llarena-Barroso Cristina 
Published: December 2022

Resumen
Objetivo La ansiedad y/o depresión juegan un papel fundamental en la forma en la que el paciente afronta la patología osteoarticular. El objetivo de este estudio es describir el impacto de los trastornos del estado de ánimo en la artrosis trapeciometacarpiana (TMC).
Materiales y Métodos Se realizó un estudio descriptivo en pacientes diagnosticados de rizartrosis entre enero de 2018 y enero de 2020. Se recogieron tanto los factores clínicos y demográficos: edad, género, índice de masa corporal (IMC), y diagnóstico de ansiedad y/o depresión; así como los propios de la patología: lateralidad, grado de rizartrosis, fuerza de puño, y fuerza de pinza. También se evaluaron los puntajes en la escala visual analógica de dolor (EVA) y la versión corta del cuestionario de Discapacidades del Brazo, Hombro y Mano (Quick Disabilities of the Arm, Shoulder and Hand – QuickDASH, en inglés).
Resultados Fueron revisados 107 pacientes (85% de mujeres) con edad media de 59,48 ± 7,5 años e IMC medio de 28,29 Kg/m2. El 21,5% de los pacientes estaban diagnosticados de ansiedad y/o depresión, el 51,4% presentaban lateralidad izquierda, y el 48,6%, derecha. Según la Escala de Eaton, el 54.2% de los pacientes eran grado III, y el 45,8%, IV. La fuerza media de puño fue de 15,64 Kg, y la de pinza, de 3,37 Kg. El puntaje medio en la EVA fue de 8,28, y en el QuickDASH, de 65,94.Se encontró una asociación estadística significativa entre el diagnóstico de ansiedad y/o depresión y el género (p = 0.023), la fuerza de pinza (p = 0,007), y el QuickDASH (p = 0.004). No se vio esta relación estadística con otros parámetros. La significación respecto a la fuerza de pinza desapareció al corregir por género.
Conclusión La presencia de ansiedad y/o depresión en los pacientes con rizartrosis se asocia con el género femenino y con una peor valoración de la funcionalidad por parte del paciente (puntajes altos en el QuickDASH), pero no con el dolor según la EVA. Esto nos indica la importancia de siempre considerar los trastornos del estado de ánimo cuando estudiemos a nuestros pacientes, dada su influencia en la percepción de la patología osteoarticular.
Effect of Different Root Canal Drying Protocols on the Bond Strength of Two Bioceramic Sealers
Authors: Frasquetti Karine Santos , Piasecki Lucila , Kowalczuck Alexandre , Carneiro Everdan , Westphalen Vânia Portela Ditzel , Neto Ulisses Xavier da Silva 
Published: December 2022

Summary
Objectives This study evaluated in vitro the effect of two different drying protocols on the dentin bond strength of two different bioceramic sealers (Sealer Plus BC [SP] and Bio C Sealer [BCS]). Bond strength and failure mode were evaluated according to the sealer, drying protocol, and root canal third.
Materials and Methods Sixty extracted human mandibular single-rooted premolars were selected after anatomical standardization. The crowns were sectioned and root canals were prepared. Roots were randomly divided into four groups (n = 15 each). Each group was assigned a combination of one of the evaluated sealers (SP or BCS) and one of the drying protocols: canals dried with paper points (PP) or irrigation with saline followed by aspiration with silicon cannulas (IA). Obturations were performed using a single-cone technique. The teeth were temporized and stored for 7 days (100% humidity, 37°C). Roots were cut to obtain 2 mm thick discs for each third (coronal, middle, and apical). Push-out tests were performed on a universal testing machine, and the bond strength (MPa) of each specimen was calculated by dividing the load (N) by the interface area. Failure type was assessed under ×4 magnification.
Statistical Analysis Data were statistically analyzed with a significance set at 5%. An analysis of variance test followed by the Games-Howell post-hoc test was used to compare the mean values between the groups and the interaction of the variables.
Results The predominant failure type was cohesive, followed by mixed failure and adhesive in all groups. The apical third presented the highest bond strength (p < 0.05) regardless of the group, followed by the middle and coronal thirds. Overall, the SP PP group had the highest mean bond strength (p < 0.01), but the SP sealer was negatively affected by the IA drying protocol in the coronal and middle thirds. The BCS presented similar results within the third stage, regardless of the drying protocol.
Conclusions Sealer Plus BC had a higher bond strength than Bio C Sealer, but it was negatively affected by the irrigation-aspiration protocol in the coronal and middle thirds. For the apical third, there was no difference between the groups; thus, a similar bond strength was observed regardless of the drying protocol or sealer.
Removing AI’s sentiment manipulation of personalized news delivery
Authors: Wu Chuhan , Wu Fangzhao , Qi Tao , Zhang Wei-Qiang , Xie Xing , Huang Yongfeng 
Published: December 2022

AbstractArtificial intelligence (AI) is empowering personalized online news delivery to accommodate people’s information needs and combat information overload. However, AI models learned from user data are inheriting and amplifying some underlying human prejudice such as the sentiment bias of news reading, which may lead to potential negative societal effects and ethical concerns. Here, substantial evidence shows that AI is manipulating the sentiment orientation of news displayed to users by promoting the presence chance of negative news, even if there is no human interference. To mitigate this manipulation, a sentiment-debiasing method based on a decomposed adversarial learning framework is proposed, which can reduce 97.3% of sentiment bias with only 2.9% accuracy sacrifice. Our work provides the potential in improving AI’s responsibility in many human-centered applications such as online journalism and information spread.
Exploring the promoting effect of working time reduction on life satisfaction using Germany as a case study
Authors: Shao Qinglong 
Published: December 2022

AbstractWorktime reduction’s effect on life satisfaction is an important issue but one that has not been fully studied. This article fills this gap and uses an ordered probit model to analyse the working time reduction impact on life satisfaction in Germany by using the European Social Survey data, the mediating effect of health and cross-partner effect are also explored. A significantly negative correlation between working time and life satisfaction are revealed, showing that a short working week can improve Germans’ life satisfaction. Health is confirmed to be the important intermediate variable in the ‘worktime–health–life satisfaction’ nexus and about 28% of the satisfaction among German people is due to the change in health explained by working hours. Further, we find that high-earners prefer to work long hours whereas low-earners tend to work less; middle-earners show no personal preferences. Cross-partner effects are confirmed, as a male’s short working week can satisfy their partner, while a female’s long working hours can improve their partner’s life satisfaction. In light of this, working hours should be restricted to avoid unsatisfaction induced by overtime work and overtime compensation regulations should be strictly implemented, policy-makers also need to take gender differences into consideration.
Recent advances in cancer fusion transcript detection
Authors: Dorney Ryley , Dhungel Bijay P , Rasko John E J , Hebbard Lionel , Schmitz Ulf 
Published: December 2022

Abstract
Extensive investigation of gene fusions in cancer has led to the discovery of novel biomarkers and therapeutic targets. To date, most studies have neglected chromosomal rearrangement-independent fusion transcripts and complex fusion structures such as double or triple-hop fusions, and fusion-circRNAs. In this review, we untangle fusion-related terminology and propose a classification system involving both gene and transcript fusions. We highlight the importance of RNA-level fusions and how long-read sequencing approaches can improve detection and characterization. Moreover, we discuss novel bioinformatic tools to identify fusions in long-read sequencing data and strategies to experimentally validate and functionally characterize fusion transcripts.
Spectral adjustment for spatial confounding
Authors: Guan Yawen , Page Garritt L , Reich Brian J , Ventrucci Massimo , Yang Shu 
Published: December 2022

Summary
Adjusting for an unmeasured confounder is generally an intractable problem, but in the spatial setting it may be possible under certain conditions. We derive necessary conditions on the coherence between the exposure and the unmeasured confounder that ensure the effect of exposure is estimable. We specify our model and assumptions in the spectral domain to allow for different degrees of confounding at different spatial resolutions. One assumption that ensures identifiability is that confounding present at global scales dissipates at local scales. We show that this assumption in the spectral domain is equivalent to adjusting for global-scale confounding in the spatial domain by adding a spatially smoothed version of the exposure to the mean of the response variable. Within this general framework, we propose a sequence of confounder adjustment methods that range from parametric adjustments based on the Matérn coherence function to more robust semiparametric methods that use smoothing splines. These ideas are applied to areal and geostatistical data for both simulated and real datasets.
Lower levels of small HDL particles associated with increased infectious disease morbidity and mortality: a population-based cohort study of 30 195 individuals
Authors: Harsløf Mads , Pedersen Kasper M , Afzal Shoaib , Davey Smith George , Nordestgaard Børge G 
Published: December 2022

AbstractAimsLow levels of HDL cholesterol have been associated with increased risk of infectious disease morbidity and mortality. Nuclear magnetic resonance (NMR) spectroscopy permits the measurement of HDL particle count and allows further subclassification according to particle size. We tested the hypothesis that low number of different HDL subfractions is associated with increased infectious disease morbidity and mortality.Methods and resultsHDL particle counts were measured using NMR spectroscopy in 30 195 individuals aged 22–99 years from the Copenhagen General Population Study. Using multiple-event Cox regression and cause-specific hazard models, we assessed risk of hospitalizations due to infection and infectious disease-related death, from 2003 through 2018. During follow-up, 9303 individuals had one or more infectious disease events, and 1558 experienced infectious disease-related death. In multifactorial adjusted analyses, low number of small and medium HDL particles was associated with increased risk of any infection and infectious disease-related death, whereas low number of large and extra-large HDL particles was not. A very high number of small and medium HDL particles was also associated with increased risk of any infection, but not with infectious disease-related death. For small and medium HDL particles and compared to individuals in the 91–95th percentile, hazard ratios (HRs) in individuals in the lowest percentile were 2.31 (95% confidence interval: 1.75, 3.05) for any infection and 3.23 (2.08, 5.02) for infectious disease-related death. For the highest percentile, corresponding HRs were 1.36 (1.07, 1.74) and 1.06 (0.57, 1.98), respectively. Individuals in the lowest percentile had increased risk of pneumonia (HR: 1.86; 95% confidence interval: 1.30, 2.65), sepsis (2.17; 1.37, 3.35), urinary tract infection (1.76; 1.17, 2.63), skin infection (1.87; 1.24, 2.81), gastroenteritis (1.78; 1.01, 3.16), and other infections (2.57; 1.28, 5.16).ConclusionLow number of the small HDL particles was associated with increased infectious disease morbidity and mortality.
The modular pYT vector series employed for chromosomal gene integration and expression to produce carbazoles and glycolipids in P. putida
Authors: Weihmann Robin , Kubicki Sonja , Bitzenhofer Nora Lisa , Domröse Andreas , Bator Isabel , Kirschen Lisa-Marie , Kofler Franziska , Funk Aileen , Tiso Till , Blank Lars M , Jaeger Karl-Erich , Drepper Thomas , Thies Stephan , Loeschcke Anita 
Published: December 2022

Abstract
The expression of biosynthetic genes in bacterial hosts can enable access to high-value compounds, for which appropriate molecular genetic tools are essential. Therefore, we developed a toolbox of modular vectors, which facilitate chromosomal gene integration and expression in Pseudomonas putida KT2440. To this end, we designed an integrative sequence, allowing customisation regarding the modes of integration (random, at attTn7, or into the 16S rRNA gene), promoters, antibiotic resistance markers as well as fluorescent proteins and enzymes as transcription reporters. We thus established a toolbox of vectors carrying integrative sequences, designated as pYT series, of which we present 27 ready-to-use variants along with a set of strains equipped with unique ‘landing pads’ for directing a pYT interposon into one specific copy of the 16S rRNA gene. We used genes of the well-described violacein biosynthesis as reporter to showcase random Tn5-based chromosomal integration leading to constitutive expression and production of violacein and deoxyviolacein. Deoxyviolacein was likewise produced after gene integration into the 16S rRNA gene of rrn operons. Integration in the attTn7 site was used to characterise the suitability of different inducible promoters and successive strain development for the metabolically challenging production of mono-rhamnolipids. Finally, to establish arcyriaflavin A production in P. putida for the first time, we compared different integration and expression modes, revealing integration at attTn7 and expression with NagR/PnagAa to be most suitable. In summary, the new toolbox can be utilised for the rapid generation of various types of P. putida expression and production strains.
Role of Hypoxia-inducible factor 1α in host defense during pneumococcal pneumonia
Authors: Pereverzeva Liza , Otto Natasja A , Peters-Sengers Hessel , Roelofs Joris J T H , de Vos Alex F , van der Poll Tom 
Published: December 2022

Abstract
Hypoxia-inducible factor (HIF)1α is a transcription factor involved in cellular metabolism and regulation of immune cell effector functions. Here, we studied the role of HIF1α in myeloid cells during pneumonia caused by the major causative pathogen, Streptococcus pneumoniae (Spneu). Mice deficient for HIF1α in myeloid cells (LysMcreHif1αfl/fl) were generated to study the in vitro responsiveness of bone marrow-derived macrophages (BMDMs) and alveolar macrophages (AMs) to the Gram-positive bacterial wall component lipoteichoic acid (LTA) and heat-killed Spneu, and the in vivo host response after infection with Spneu via the airways. Both BMDMs and AMs released more lactate upon stimulation with LTA or Spneu, indicative of enhanced glycolysis; HIF1α-deficiency in these cells was associated with diminished lactate release. In BMDMs, HIF1α-deficiency resulted in reduced secretion of tumor necrosis factor (TNF)α and interleukin (IL)-6 upon activation with Spneu but not LTA, while HIF1α-deficient AMs secreted less TNFα and IL-6 in response to LTA, and TNFα after Spneu stimulation. However, no difference was found in the host response of LysMcreHif1αfl/fl mice after Spneu infection as compared to controls. Similar in vivo findings were obtained in neutrophil (Mrp8creHif1αfl/fl) HIF1α-deficient mice. These data suggest that myeloid HIF1α is dispensable for the host defense during pneumococcal pneumonia.
ACCELERATED BRAIN AGING IS ASSOCIATED WITH MORTALITY ACROSS RACE
Authors: Casanova Ramon , Anderson Andrea , Barnard Ryan , Walker Keenan , Hughes Timothy , Kritchevsky Stephen , Wagenknecht Lynne 
Published: December 2022

Abstract
There is an increasing interest in using machine learning and artificial intelligence to estimate chronological age using neuroimaging data. The gap between chronological age and estimated brain age (brain age gap, BAG) is used as a measure of accelerated/resilient brain aging. Accelerated brain aging has been associated with increased mortality risk. However, these reports are based on cohorts mostly composed by white individuals. Here we capitalized on the racially diverse nature of the Atherosclerosis Risk in Communities Study (ARIC) cohort to investigate associations of brain across race. We used brain MRI scans from 1172 cognitively normal ARIC participants that were collected at ARIC Visit 5. Of those 772 were White and 366 were African Americans. We used Cox regression models to investigate BAG values associations with mortality. There were 163 deaths (dw = 124 and daa = 39) over 8 years of follow-up. Participants were stratified by tertiles according to BAG values. We found that, compared to those individuals with BAG scores in the highest tertile (&gt;=1.15), those who scored in the lowest tertile (&lt;= -1.3 years) to be associated with significantly lower mortality among the White (HR=0.41, 95% CI, [0.26–0.66], p &lt; 0.001) and Black (HR=0.43, 95% CI, [0.20–0.92], p = 0.03) participants after adjusting for age, race-center, sex, education, diabetes, smoking and hypertension. Our analyses show that our approach to estimate chronological age using high-dimensional elastic net regression, produces BAG values which are associated with mortality not only in White individuals but also in African Americans.
A Quantitative Method for the Study of HIV-1 andMycobacterium tuberculosisCoinfection
Authors: Donnellan Samantha , Pennington Shaun H , Ruggiero Alessandra , Martinez-Rodriguez Carmen , Pouget Marion , Thomas Jordan , Ward Steve A , Pollakis Georgios , Biagini Giancarlo A , Paxton William A 
Published: December 2022

AbstractMycobacterium tuberculosis and human immunodeficiency virus-1 (HIV-1) syndemic interactions are a major global health concern. Despite the clinical significance of coinfection, our understanding of the cellular pathophysiology and the therapeutic pharmacodynamic impact of coinfection is limited. Here, we use single-round infectious HIV-1 pseudotyped viral particles expressing green fluorescent protein alongside M. tuberculosis expressing mCherry to study pathogenesis and treatment. We report that HIV-1 infection inhibited intracellular replication of M. tuberculosis and demonstrate the therapeutic activity of antiviral treatment (efavirenz) and antimicrobial treatment (rifampicin). The described method could be applied for detailed mechanistic studies to inform the development of novel treatment strategies.
Poverty Reduction through Growth, Redistribution and Social Inclusion in Times of COVID-19: Kenyan Evidence on the Underlying Mechanisms
Authors: Mwabu Germano 
Published: December 2022

AbstractThe paper looks at the nexus between growth, poverty, inequality and redistribution in Africa, using Kenya as a case study. The existing literature shows a strong causal link from growth to poverty reduction. This link is the basis for the pro-poor poverty reduction strategy. There is evidence from the AERC studies that, poverty reduction in a given period is associated with higher growth rates in successive periods that are inequality-reducing and conceptually long lasting. This virtuous spiral of poverty reduction, higher growth and less inequality over time, is the basis for the pro-growth poverty reduction strategy that has recently been emphasized in the literature ( Thorbecke and Ouyang, 2022). The two poverty reduction strategies, a pro-poor strategy and a pro-growth poverty reduction one, complement each other, sustaining household escapes from poverty over time. The paper provides evidence from Kenya showing that human capital formation is the key mechanism underlying the virtuous spiral of lower poverty, higher growth and less inequality as the economy progresses through time. A perspective on robustness of the virtuous spiral in the context of COVID-19 and other pandemics is offered in the concluding section of the paper.
Variations in life cycle and seasonal sex ratio in the rhizocephalan Peltogasterella gracilis (Boschma, 1927) (Cirripedia: Rhizocephala: Peltogasterellidae)
Authors: Kajimoto Asami , Høeg Jens T , Kato Kenji , Yusa Yoichi 
Published: December 2022

Abstract
Most individuals of the rhizocephalan Peltogasterella gracilis (Boschma, 1927) produce only male (larger) or female (smaller) offspring, but some mixed-sex broods appear in autumn. Such variability may be an adaptation to the seasonally changing availability of hosts (for female larvae) and conspecific females (for male larvae), but details of the seasonal variation in the sex ratio and its ultimate causes have not been fully studied in P. gracilis. We studied the life cycle, host availability, and seasonal sex-ratio variation in P. gracilis by samplings from spring to autumn in 2017–2020 in Otaru, and additionally from winter to spring of 2007 in Oshoro Bay, Hokkaido, northern Japan. We measured its prevalence on the hermit crab Pagurus lanuginosus De Haan, 1849, the number of males per externa, the proportion of externae brooding different embryonic stages, and embryo size that are linked to sex. The prevalence was about 20% in most of the sampling period. The number of males per externa was 0.01–0.74 in June 2018–2020, but increased in later months to nearly 1.0. Eyed embryos and nauplii before hatching were common from June or July to September, but they were rare in other seasons. Female embryos were observed in all sampling periods, but male embryos were not found in July or August, by which time most females already have males implanted within their receptacles. It is suggested that P. gracilis releases both female and male larvae according to the availability of unparasitized hosts and of virgin externae, respectively.