bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rivaroxaban treatment for asymptomatic venous thromboembolism: Insights from the J’xactly Study
Authors: Migita Shohei , Okumura Yasuo , Fukuda Ikuo , Nakamura Mashio , Yamada Norikazu , Takayama Morimasa , Maeda Hideaki , Yamashita Takeshi , Ikeda Takanori , Mo Makoto , Yamazaki Tsutomu , Hirayama Atsushi 
Published: March 2023

Abstract
Background: An established treatment strategy against asymptomatic pulmonary embolism (PE) or deep vein thrombosis (DVT) remains lacking in Japan; therefore, in this study, we clarify the characteristics and outcomes of symptomatic compared to asymptomatic patients with PE (n = 419) or DVT (n = 597).
Methods: This prospective, multicenter sub-analysis of the J’xactly study in Japan included 1,016 patients (mean age, 68; 41% male) with venous thromboembolism (VTE) treated with rivaroxaban.
Results: Asymptomatic PE patients (47% of PE patients) were more likely to have active cancer and asymptomatic proximal DVT at lower severity than symptomatic PE patients, despite no differences in age, sex, or the proportion receiving intensive 30 mg/day-rivaroxaban. Patients with asymptomatic DVT (34% of DVT patients) were older, had higher rates of female sex, active cancer, and distal DVT, and received shorter, less intense rivaroxaban treatment. Incidences did not differ between asymptomatic and symptomatic PE patients for recurrent symptomatic VTE (hazard ratio [HR], 0.60; 95% confidence interval [CI], 0.22–1.62; P = 0.31) or major bleeding (HR, 0.68; 95% CI, 0.20–2.33; P = 0.58), nor between asymptomatic and symptomatic DVT patients for recurrent symptomatic VTE (HR, 0.56; 95% CI, 0.23–1.40; P = 0.21) and major bleeding (HR, 1.47; 95% CI, 0.54–3.97; P = 0.45).
Conclusions: The real-world composite adverse event rate for treatment with rivaroxaban, as physician-adjusted for dose and duration, was similar between asymptomatic and symptomatic patients regardless of the presence of PE or DVT, suggesting a favorable safety profile for potential rivaroxaban treatment for asymptomatic VTE.
Autoimmune diseases presenting with IgG4 related lesions at atypical sites - a tale of two cases with literature review
Authors: Baisya Ritasman , Yerram Keerthivardhan 
Published: March 2023

AbstractIntroduction IgG4RD overlapping with clinically overt autoimmune diseases (Rheumatoid arthritis ( RA) or anti-phospholipid syndrome (APS) is rarely reported in the literature. Here we report a tale of two cases with known autoimmune diseases – RA and primary APS presented with IgG4-related lesions involving unusual sites – oesophagus and right atrium of the heart respectively Case – The first case was a known RA presented with dysphagia, imaging suggestive of encasing mass in oesophagus causing stricture , biopsy was suggestive of IgG4RD. The second patient was a known case of primary APS presented with breathlessness, imaging revealed right atrial mass with histopathology was suggestive of IgG4RD . Both patients had significant improvement after starting steroid. Discussion – A few cases of known RA presenting with IgG4 mass is reported in literature though RA patients are frequently found to have increased number of IgG4 in their sera. Primary APS with IgG4 lesion is extremely uncommon. Though a several case reports or series are published regarding oesophageal and cardiac IgG4 related lesions, such lesions in the background of known autoimmunity is first described by us . Conclusion – This is the first case series of two cases with IgG4 related lesions in atypical site in known autoimmune diseases .
New strategies for the new environment. Stowaway feather star on crab Hyas sp. - Spitsbergen (Arctic)
Authors: Deja Kajetan , Dragańska-Deja Katarzyna , Węsławski Jan Marcin 
Published: March 2023

Abstract
This publication presents a possibly never-before-recorded new behaviour, adaptations of the filter feeder crinoid using Hyas crabs in the inner, heavily loaded with suspension runoff part of the Spitsbergen fjords. The work used a 16-hour and 45-minute time-lapse sequence showing the decompositions of Atlantic Cod. During the exposure, apart from typical organisms such as carrion crustaceans, crabs and starfish, several individuals of crinoids were observed. One of the crinoids attached its cirri to the edge of the platform for most of the exposure. The remaining individuals observed attached to the carapace of Hyas crabs for 6 hours 55 minutes. It was also found, basis on analysis of the video material from 202 locations examined in the summer season between 2015-2020 using a drop camera, additionally two locations with a positive occurrence of a comatulida. Both locations in the Ekmanfjorden and in the interior of the Vanmijenfjorden are areas under the strong influence of a glacier or a glacial river. So far, the occurrence of crinoids has been found mainly in locations outside of the influence of turbid waters from fjords. We believe that the new observation of the comatulida behaviour will allow it to colonize new regions gradually exposed by the retreating glaciers.
MSRHNN:Multidimensional Social Relation under Heterogeneous Neural Network for Recommendation
Authors: Millette Rhydian , Pinard Eulalia , Blaise Breanna , Vanier Callan 
Published: March 2023

Abstract
With the growing popularity of mobile smart devices and the availability of 4G and 5G networks, social recommendation systems have become a hot research topic for industrial applications. Social networks among users are built through social information, which can improve collaborative filtering and solve cold start and sparsity problems. Graph convolutional networks have been widely used to represent the interactions and structural relationships among entities, but the exponential increase of the domain introduces a new problem. In this paper, we propose a multidimensional social relation under heterogeneous neural network (MSRHNN). By embedding historical evaluations, various social networks constituting different dimensions, the attention integration of different social networks on user preferences is achieved. A static graph encoder is used to process the node representation of each heterogeneous graph at different time steps, which includes the node attribute information and edge information, to capture the changing feature information of the nodes in all time steps of the dynamic graph, and to obtain an effective node representation at each time step. The goal of the heterogeneous dynamic graph neural network is to capture the changing node representations of the same nodes and different nodes in the graph network at different time steps, in order to better perform the task of node classification in dynamic graphs. In this paper, the model of heterogeneous dynamic graph neural network is verified from data, and experiments show that heterogeneous dynamic graph neural network outperforms other representation learning methods.
Trophic classification and assessment of lake health using indexing approach and geostatistical methods for sustainable management of water resources
Authors: Auddy Nilabhra , Kumar Rai Atul , Chatterjee Sharmistha , Pobi Krishnendu , Dutta Subhankar , Nayek Sumanta 
Published: March 2023

Abstract
This study aims to analyse the spatio-temporal trends in water quality, trophic state, and organic contamination of an alpine lake in the Darjeeling Himalaya through field investigations and to portray a comprehensive picture using multivariate analysis. Analysed water parameters have shown notable seasonal variations and were within the acceptable range for inland surface water. Water quality index (WQI) and organic pollution index (OPI) values have displayed ‘poor’ to ‘heavily polluted’ status in the pre-monsoon season, with marginally better conditions during the post-monsoon studies. Trophic state indices (TSIs) values revealed ‘eutrophic to highly eutrophic’ conditions during the investigation period. The results of the PCA have depicted three major determining factors (i.e., anthropogenic contribution, geogenic or weathering, and seasonal/climatic factors) that control the overall pollution level in the lake water system. The current study can potentially be a benchmark for assessing and undertaking management and restoration measures for this nascent alpine ecosystem.
Exploring Scoring Function Space: Developing Computational
Models for Drug Discovery
Authors: Bitencourt-Ferreira Gabriela , Villarreal Marcos A. , Quiroga Rodrigo , Biziukova Nadezhda , Poroikov Vladimir , Tarasova Olga , de Azevedo Junior Walter F. 
Published: March 2023

Background:
The idea of scoring function space established a systems-level
approach to address the development of models to predict the affinity of drug molecules
by those interested in drug discovery.

Objective:
Our goal here is to review the concept of scoring function space and how to
explore it to develop machine learning models to address protein-ligand binding affinity.

Methods:
We searched the articles available in PubMed related to the scoring function
space. We also utilized crystallographic structures found in the protein data bank (PDB)
to represent the protein space.

Results:
The application of systems-level approaches to address receptor-drug interactions
allows us to have a holistic view of the process of drug discovery. The scoring function
space adds flexibility to the process since it makes it possible to see drug discovery
as a relationship involving mathematical spaces.

Conclusion:
The application of the concept of scoring function space has provided us
with an integrated view of drug discovery methods. This concept is useful during drug
discovery, where we see the process as a computational search of the scoring function
space to find an adequate model to predict receptor-drug binding affinity.
Carbonic Anhydrase 4 Serves as A Novel Prognostic Biomarker and
Therapeutic Target for Non-Small Cell Lung Cancer: A Study Based on
TCGA Samples
Authors: Xu Bo , Lou Yang , Xu Xiaoyi , Li Xianshuai , Tian Xin , Yu Zhaonan , Chen Xianguo 
Published: March 2023

Background:
Carbonic anhydrase 4 (CA4) is a member of a large family of zinc metalloenzymes
that catalyze the reversible hydration of carbon dioxide and was found to have low expression
in non-small cell lung cancer (NSCLC). However, the specific role of CA4 in NSCLC and
the underlying mechanisms remain unknown.

Methods:
The bioinformatic analysis on lung adenocarcinoma (LUAD) and lung squamous cell
carcinoma (LUSC) datasets downloaded from The Cancer Genome Atlas (TCGA) database was
performed. We found that CA4 expression was lower in tumors than that in normal tissues, which
were verified by Real-time PCR. Lower CA4 levels were significantly associated with higher T
stages in LUAD and LUSC cohorts. Multivariate analysis showed that CA4 is an independent
prognostic factor for NSCLC. Furthermore, the expression of CA4 also correlated with immune infiltration
and drug sensitivity.

Results:
Ectopic expression of CA4 decreased NSCLC cell proliferation in vitro by CCK-8 assay.
CA4 caused G0/G1 cell cycle arrest by cell experiments. Mechanistic studies found that CA affects
the cell cycle and inhibits cell proliferation by downregulating the expression of CDK2.

Conclusion:
The present findings highlight the role of CA4 in NSCLC and identify CA4 as a potential
novel diagnostic and prognostic biomarker for the treatment of NSCLC.
Chronic Administration of Methamphetamine Aggravates
Atherosclerotic Vulnerable Plaques in Apolipoprotein E Knockout
Mice Fed with a High-cholesterol Diet
Authors: Cui Xiaoxue , Gao Bo , Yu Yijun , Gu Ye , Hu Liqun 
Published: March 2023

Background:
It has been observed previously that chronic methamphetamine
(METH) administration could upregulate neuropeptide Y (NPY) expression and promote
atherosclerotic formation in apolipoprotein E knockout (ApoE-/-) mice fed with a normal
cholesterol or high diet and NPY might be involved in the pathogenesis of METHinduced
atherogenic effects through NPY Y1 receptor pathway. Vulnerable coronary
atherosclerotic plaque (VP) is a critical pathological finding responsible for the acute
coronary syndrome (ACS). In this study, we explored whether METH abuse could
aggravate the formation of VP in ApoE-/- mice fed with high cholesterol diet.

Objective:
The purpose of this study was to observe if chronic METH administration
could aggravate vulnerable plaque (VP) formation in ApoE-/- mice fed with a highcholesterol
diet

Methods:
Male ApoE-/- mice fed with a high-cholesterol diet were intraperitoneally
injected with normal saline (NS) or 8 mg/kg/day METH (M8) for 24 weeks. Body weight
was monitored from baseline to 24 weeks at 2 weeks intervals. After 24 weeks of
treatment, plasma lipid variables were measured. Movat's staining and immunohistochemical
staining were performed on frozen sections of the aortic roots to calculate
VP percentage and intraplaque hemorrhage (IPH) percentage and detect expression of
NPY, vascular endothelial growth factor (VEGF), and CD31. In vitro, the expressions of
Y2R, VEGF, and CD31 were detected by immunofluorescence staining in aortic
endothelial cells incubated with PBS, 100μM METH, 10nmol NPY, or 100μM METH plus
10nmol NPY for 12 hours.

Results:
The CD31 positive area, percentage of IPH, VP, and the expressions of NPY
and VEGF were significantly increased in the M8 group than in the NS group. In vitro,
the expressions of Y2R, VEGF, and CD31 were significantly increased in the
METH+NPY group than in the PBS, METH, and NPY groups and these effects could be
blunted by treatment with a Y2R antagonist or DPPIV inhibitor.

Conclusion:
Chronic METH administration could aggravate VP in ApoE-/- mice fed with
a high-cholesterol diet, possibly through upregulating vascular NPY and VEGF
expression and promoting angiogenesis and vessel rupture in atherosclerotic plaques.
Our findings indicated that increased VP formation might contribute to the development
of acute coronary syndrome post-chronic METH abuse by activating DPPIV/NPY/Y2R
pathway.
Epigenetics of Fear, Anxiety and Stress – Focus on Histone Modifications
Authors: Ell Marco A. , Schiele Miriam A. , Iovino Nicola , Domschke Katharina 
Published: March 2023

Abstract:
Fear-, anxiety- and stress-related disorders are among the most frequent mental disorders.
Given substantial rates of insufficient treatment response and often a chronic course, a better understanding
of the pathomechanisms of fear-, anxiety- and stress-related disorders is urgently warranted.
Epigenetic mechanisms such as histone modifications - positioned at the interface between the biological
and the environmental level in the complex pathogenesis of mental disorders - might be highly informative
in this context. The current state of knowledge on histone modifications, chromatin-related
pharmacology and animal models modified for genes involved in the histone-related epigenetic machinery
will be reviewed with respect to fear-, anxiety- and stress-related states. Relevant studies, published
until 30th June 2022, were identified using a multi-step systematic literature search of the Pub-
Med and Web of Science databases. Animal studies point towards histone modifications (e.g.,
H3K4me3, H3K9me1/2/3, H3K27me2/3, H3K9ac, H3K14ac and H4K5ac) to be dynamically and
mostly brain region-, task- and time-dependently altered on a genome-wide level or gene-specifically
(e.g., Bdnf) in models of fear conditioning, retrieval and extinction, acute and (sub-)chronic stress.
Singular and underpowered studies on histone modifications in human fear-, anxiety- or stress-related
phenotypes are currently restricted to the phenotype of PTSD. Provided consistent validation in human
phenotypes, epigenetic biomarkers might ultimately inform indicated preventive interventions as well
as personalized treatment approaches, and could inspire future innovative pharmacological treatment
options targeting the epigenetic machinery improving treatment response in fear-, anxiety- and stressrelated
disorders.
Pyridazinone-substituted Benzenesulfonamides Demonstrate Inhibition of
Monoamine Oxidase
Authors: Petzer Anél , Shetnev Anton , Efimova Julia , Korsakov Mikhail , Filimonov Sergei , Petzer Jacobus P. 
Published: March 2023

Background:
The monoamine oxidase (MAO) enzymes are important drug targets. Inhibitors
of MAO-A and MAO-B have been used to treat the symptoms of depression and Parkinson’s disease.

Methods:
A series of seventeen pyridazinone-substituted benzenesulfonamides was synthesized and evaluated
as potential inhibitors of human MAO-A and MAO-B. This study is a continuation of our interest in
the pharmacological activities of sulfonamide compounds.

Results:
Among the compounds evaluated, only 10 and 18 demonstrated appreciable inhibition of MAOB
with IC50 values of 2.90 and 4.36 μM, respectively. None of the benzenesulfonamides inhibited the
MAO-A isoform. Potential binding orientations and interactions of 10 and 18 with the active site of
MAO-B were investigated by computational approaches.

Conclusion:
Although these potencies are modest, this study is the first report on MAO inhibition by this
class of compounds. Active MAO-B inhibitors may serve as leads for the future discovery of therapeutic
agents for neurodegenerative disorders, such as Parkinson’s disease.
A Computed Tomography-based Radiomics Analysis of Low-energy
Proximal Femur Fractures in the Elderly Patients
Authors: Mohammadi Seyed Mohammad , Moniri Samir , Mohammadhoseini Payam , Hanafi Mohammad Ghasem , Farasat Maryam , Cheki Mohsen 
Published: March 2023

Introduction:
Low-energy proximal femur fractures in elderly patients result from factors,
like osteoporosis and falls. These fractures impose high rates of economic and social costs. In
this study, we aimed to build predictive models by applying machine learning (ML) methods on
radiomics features to predict low-energy proximal femur fractures.

Methods:
Computed tomography scans of 40 patients (mean ± standard deviation of age = 71 ± 6)
with low-energy proximal femur fractures (before a fracture occurs) and 40 individuals (mean ±
standard deviation of age = 73 ± 7) as a control group were included. The regions of interest, including
neck, trochanteric, and intertrochanteric, were drawn manually. The combinations of 25
classification methods and 8 feature selection methods were applied to radiomics features extracted
from ROIs. Accuracy and the area under the receiver operator characteristic curve (AUC) were
used to assess ML models' performance.

Results:
AUC and accuracy values ranged from 0.408 to 1 and 0.697 to 1, respectively. Three
classification methods, including multilayer perceptron (MLP), sequential minimal optimization
(SMO), and stochastic gradient descent (SGD), in combination with the feature selection method,
SVM attribute evaluation (SAE), exhibited the highest performance in the neck (AUC = 0.999,
0.971 and 0.971, respectively; accuracy = 0.988, 0.988, and 0.988, respectively) and the trochanteric
(AUC = 1, 1 and 1, respectively; accuracy = 1, 1 and 1, respectively) regions. The same
methods demonstrated the highest performance for the combination of the 3 ROIs’ features (AUC
= 1, 1 and 1, respectively; accuracy =1, 1 and 1, respectively). In the intertrochanteric region, the
combination methods, MLP + SAE, SMO + SAE, and SGD + SAE, as well as the combination of
the SAE method and logistic regression (LR) classification method exhibited the highest performance
(AUC = 1, 1, 1 and 1, respectively; accuracy= 1, 1, 1 and 1, respectively).

Conclusion:
Applying machine learning methods to radiomics features is a powerful tool to predict
low-energy proximal femur fractures. The results of this study can be verified by conducting
more research on bigger datasets.
Comparative Study for the Absorption of Carbon Dioxide in
Aqueous Amine Solvents for Enhanced Loading
Authors: Sood Akash , Thakur Avinash , Ahuja Sandeep Mohan 
Published: March 2023

Aims:
The current study aimed to investigate the CO2 absorption capacity of the aqueous
alkanolamine, including primary, secondary, tertiary, and sterically hindered amines and polyamines,
i.e., monoethanolamine (MEA), diethanolamine (DEA), triethanolamine (TEA) and 2-
amino-2-methyl-1-propanol (AMP), tetraethylenepentamine (TEPA), triethylenetetramine (TETA), 3-
(Methylamino)propylamine (MAPA), and diethylenetriamine (DETA) at 40, 60, and 80°C at 1.1 bar.

Methods:
An increase in reaction temperature caused a decrement in CO2 loading across the board
for all solvents. The trend of CO2 loading was TEA < MEA < DEA < AMP < MAPA < DETA <
TETA < TEPA at 40 ºC, TEA < DEA < MEA < AMP < MAPA < DETA < TETA < TEPA, at
60ºC and TEA < DEA < AMP < MEA < MAPA < DETA < TETA < TEPA at 80ºC.

Results:
The results indicated that TEPA has great potential to be utilized as an energy-efficient
and non-corrosive solvent for CO2 capture since it has outperformed all other aqueous amine solvents
in this present study. Furthermore, the CO2 loading of sterically hindered amine (AMP) at the
same temperature was found to be higher than primary, secondary, and tertiary amines. Heat of
absorption (Δ Η abs) was also determined to gauge the energy requirement to regenerate absorbents
for cyclic loading from an economic viewpoint.

Conclusion:
DETA has the highest Δ Η abs = 84.48 kJ/mol. On the contrary, the long-chain tertiary
amine TEA resulted in the least Δ Η abs = 40.21 kJ/mol, among all other solvents. Whereas the sterically
hindered amine (AMP) was observed to possess mid-range Δ Η abs, i.e., 58.76 kJ/mol.
Among all selected solvents, polyamines showed higher Δ Η abs than other conventional amines
pertaining to the precedence of TEA<AMP<DEA< MEA<TETA<TEPA<MAPA<DETA.