bluuebunny/crossref_metadata_2025_split huggingface dataset:
Yoshio Gonnosuke and His Comparative Dutch‐Japanese Syntax: Glimpses at the Unpublished Second Part of Siebold's “Epitome Linguae Japonicae”**
Authors: Osterkamp Sven 
Published: January 2023

AbstractAfter outlining the life and works of interpreter Yoshio Gonnosuke, this paper introduces the manuscript witnesses of his hitherto unstudied comparative Dutch–Japanese syntax written in the mid‐1820s, which was modelled on Pieter Weiland's Nederduitsche spraakkunst (1805). This is followed by a closer look at the process of compilation and publication of Philipp Franz von Siebold's “Epitome linguae japonicae,” of which only the first part was published in 1826. Evidence is provided to confirm Yoshio's involvement in this work and to suggest that Yoshio's syntax was in fact intended to form the core of its unpublished second part.
The impact of chief executive officer narcissism on environmental, social, and governance reporting
Authors: Kind Finja Lena , Zeppenfeld Jennifer , Lueg Rainer 
Published: January 2023

AbstractWe analyze the effect of chief executive officer (CEO) narcissism on environmental, social, and governance (ESG) reporting. The study relies partly on hand‐collected, visual data and covers 57 German DAX 40 and MDAX companies from 2016 to 2020 (266 company‐year observations, Bloomberg database). Looking into the sub‐scores of ESG, CEO narcissism has a negative and linear relationship with environment and governance reporting but there is no significant relationship between narcissism and social reporting. Regression analyses further suggest a U‐shaped (quadratic) relation between CEO narcissism and ESG reporting: while low to moderate degrees of narcissism affect overall ESG reporting negatively, as CEO levels of narcissism increase so does the level of reporting. Moreover, further analysis has shown that the quantity of reporting is additionally positively related to ESG performance. The study applies and validates a relatively new but easily applicable measure of narcissism and extends narcissism research in the area of curvilinear relationships. We offer several further implications for human resource managers, regulators, auditors, and (non‐)financial analysts.
Determinants and long‐term outcomes of largely uncovered struts in thin‐struts drug‐eluting stents assessed by optical coherence tomography
Authors: Moretti Francesco , Bernelli Chiara , Pellegrini Dario , Boccuzzi Giacomo , Colombo Francesco , Sirbu Vasile , Vassileva Angelina , Fiocca Luigi , Canova Paolo , Bezerra Hiram , Pereira Gabriel T. R. , Cereda Alberto , De Luca Leonardo , Saia Francesco , Capodanno Davide , Guagliumi Giulio 
Published: January 2023

AbstractBackgroundUncovered struts are a determinant of stent failure. The impact of plaque composition and procedural factors on the occurrence, evolution, and outcomes of uncovered struts in a high‐risk setting has not been investigated.ObjectiveTo investigate the determinants and long‐term clinical impact of largely uncovered struts (LUS) in thin‐struts drug‐eluting stents (DES) implanted in complex lesions by intracoronary optical coherence tomography (OCT).MethodsNinety patients with multivessel disease undergoing staged complete revascularization were randomly assigned to bioabsorbable or durable polymer DES. OCT were serially performed during the index procedure, at 3‐ and 18‐month follow‐up, and analyzed by an independent core lab. Struts were defined uncovered by OCT if no tissue was visible above the struts. LUS were defined as ≥30% of uncovered struts at 3‐month follow‐up. Clinical outcomes were the occurrence of target vessel failure (TVF) and major adverse cardiac and cerebrovascular events (MACCE) at 5‐year follow‐up.ResultsLUS occurred in 31 patients (34.4%) regardless of stent platform. At 5 years, no differences were observed in the rate of TVF (12.7% vs. 13.4%; p = 0.91) and MACCE (23.9% vs. 24.9%; p = 0.88) between the two groups. At multivariate logistic regression, plaque rupture, mean lumen diameter, proximal reference vessel area, and maximum stent deployment pressure were independent predictors of LUS.ConclusionsLUS are a frequent finding in complex coronary lesions treated with thin‐struts DES, especially in the presence of plaque rupture. However, in this study, no significant safety signal related to LUS emerged in long‐term follow‐up.
Improving efficiency and operator proficiency during percutaneous coronary interventions utilizing a standardized optical coherence tomography workflow
Authors: Khuddus Matheen A. , Darki Amir , Padaliya Bimal B. , West Nick E. J. , Rapoza Richard J. , Buccola Jana , Amis Gregory , Chehab Bassem M. , Secemsky Eric A. ,   LightLab Initiative Investigators
Published: January 2023

AbstractObjectivesThis study was designed to compare efficiency and quality metrics between percutaneous coronary intervention (PCI) procedures using optical coherence tomography (OCT) guided by a variable workflow versus a standardized workflow in a real‐world population.BackgroundThe LightLab (LL) Initiative was designed to evaluate the impact of a standardized OCT workflow during PCI to address barriers to adoption.MethodsThe LL Initiative was a multicenter, prospective, observational study. PCI efficiency data were collected from 1/21/19 to 1/8/21 from 45 physicians at 17 US centers. OCT‐guided PCIs were compared between baseline phase (variable workflow; N = 383) and the LL workflow utilization phase (N = 447). The LL workflow uses OCT to assess lesion Morphology, Length and Diameter, and then optimize outcomes by correcting for Medial dissection, stent mal‐Apposition, and under‐eXpansion (MLD MAX). Matching based on propensity scores was used to control for differences between PCIs.ResultsAfter propensity matching, 291 paired procedures were included. Integration of the LL versus variable workflow resulted in no difference in procedure time (51 min vs. 51 min, p = 0.93). There was a reduction in radiation exposure (1124 mGy vs. 1493 mGy, p < 0.0001) and contrast volume (160 cc vs. 172 cc, p < 0.001). The LL workflow decreased the proportion of underexpanded lesions (34% vs. 54%, p < 0.0001) and improved minimum stent expansion (85% vs. 79%, p < 0.0001). Number of noncompliant balloons used was reduced with the LL workflow. (2.0 vs. 1.7, p < 0.01).ConclusionsThese data suggest that standardizing imaging with the LL workflow may overcome barriers to imaging and improve PCI outcomes without prolonging procedures.
The MLD MAX OCT algorithm: An imaging‐based workflow for percutaneous coronary intervention
Authors: Shlofmitz Evan , Croce Kevin , Bezerra Hiram , Sheth Tej , Chehab Bassem , West Nick E. J. , Shlofmitz Richard , Ali Ziad A. 
Published: January 2023

AbstractAlthough extensive clinical data support the utility of intravascular imaging to guide and optimize outcomes following percutaneous coronary interventions (PCI), clinical adoption remains limited. One of the primary reasons for limited utilization may be a lack of standardization on how to best integrate the data provided by intravascular imaging practically. Optical coherence tomography (OCT) offers a high‐resolution intravascular imaging modality with integrated software automation that allows for incorporation of OCT into the routine workflow of PCIs. We suggest use of an algorithm called MLD MAX to incorporate OCT for imaging‐guided interventions: the baseline OCT imaging run is intended to facilitate procedural planning and strategizing, consisting of assessment for predominant lesion morphology (M), measurement for stent length (L) and determination of stent diameter (D); the post‐PCI OCT imaging run is designated for assessment of need for further optimization of stent result, and consists of analysis for medial dissections (M), adequate stent apposition (A) and stent expansion (X). Incorporation of the MLD MAX algorithm into daily practice guides an efficient and easily‐memorable workflow for optimized PCI procedures.
Morphology‐Dependent Aggregation‐Induced Emission of Janus Emulsion Surfactants
Authors: Marqués Pablo Simón , Krajewska Martyna , Frank Bradley D. , Prochaska Krystyna , Zeininger Lukas 
Published: January 2023

AbstractWe report a novel stimuli‐responsive fluorescent material platform that relies on an evocation of aggregation‐induced emission (AIE) from tetraphenylethylene (TPE)‐based surfactants localized at one hemisphere of biphasic micro‐scale Janus emulsion droplets. Dynamic alterations in the available interfacial area were evoked through surfactant‐induced dynamic changes of the internal droplet morphology that can be modulated as a function of the balance of interfacial tensions of the droplet constituent phases. Thus, by analogy with a Langmuir–Blodgett trough that enables selective concentration of surfactants at a liquid–gas interface, we demonstrate here a method for controllable modulation of the available interfacial area of surfactant‐functionalized liquid–liquid interfaces. We show that a morphology‐dependent alteration of the interfacial area can be used to evoke an optical signal, by selectively assembling synthesized TPE‐based surfactants on the respective droplet interfaces. A trigger‐induced increase in the concentration of TPE‐based surfactants at the liquid–liquid interfaces results in an evocation of aggregation‐induced emission (AIE), inducing an up to 3.9‐fold increase in the measured emission intensity of the droplets.
A Cu+/Thiourea Dendrimer Achieves Excellent Cytosolic Protein Delivery via Enhanced Cell Uptake and Endosome Escape
Authors: Liang Mengxiao , Cheng Yiyun , Wang Hui 
Published: January 2023

AbstractIntracellular protein delivery has attracted considerable attention in the development of protein‐based therapeutics, however, the design of highly efficient materials for robust delivery of native proteins remains challenging. This study proposes a Cu+ ‐based coordination polymer for cytosolic protein delivery with high efficacy and robustness. The phenylthiourea grafted dendrimer is coordinated with cuprous ions to prepare the polymeric carrier, which efficiently bind cargo proteins via a combination of coordination, ionic and hydrophobic interactions. The incorporation of Cu+ ions in the polymer greatly improves its cellular uptake and endosomal escape. The cuprous‐based coordination polymer successfully delivered a variety of structurally diverse proteins into various cell lines with reserved bioactivities. This study provides a new type of coordination polymers for cytosolic delivery of biomacromolecules.
Impact of a dedicated center for atrial fibrillation on resource utilization and costs
Authors: Medhekar Ankit , Mulukutla Suresh , Adams Whitney , Kristofik Amanda , Byers Erica , Thoma Floyd , Aronis Konstantinos , Barrington William , Bazaz Raveen , Bhonsale Aditya , Estes Nathan Anthony Mark , Kancharla Krishna , Voigt Andrew , Wang Norman C. , Saba Samir , Jain Sandeep K. 
Published: January 2023

AbstractBackgroundAtrial fibrillation (AF) affects millions of Americans each year and can lead to high levels of resource utilization through emergency department (ED) visits and inpatient stays.HypothesisWe hypothesized that referral of patients to a dedicated Center for AF from the ED would reduce costs of care.MethodsThe University of Pittsburgh Center for AF serves as a rapid referral center for patients with AF to avoid unnecessary inpatient admissions and provide specialized care. Patients that presented to the ED with AF and met prespecified criteria were directed to rapid outpatient follow‐up instead of inpatient admission. The primary outcome of interest was 30‐day total costs. Secondary outcomes included outpatient costs, inpatient costs, 90‐day costs, and inpatient stay characteristics.ResultsWe identified 96 patients (median age 65, 38% women) referred to the center for AF for a new diagnosis of AF between October 2017 and December 2019 and matched 96 control patients. After 30 days of follow‐up, patients referred to the center for AF had a lower average cost ($619 vs. $1252, p < 0.001) compared to controls, driven by lower costs of ED care tempered by slightly higher outpatient costs. Thirty‐day admissions and lengths of stay were also lower. These differences were persistent at 90 days.ConclusionDirecting patients with AF that present to the ED to follow‐up at a dedicated Center for AF significantly reduced overall costs, while reducing subsequent inpatient admissions and total lengths of stay in the hospital.
Does a three‐dimensional Impact Message Inventory‐Circumplex (IMI‐C) enclose an indirect measure of reactance?
Authors: Hafkenscheid Anton , Timmerman Marieke E. 
Published: January 2023

AbstractClinicians can rely on the Impact Message Inventory‐Circumplex (IMI‐C) to map their emotional reactions to their patients' communication style in octant and main dimension scores on the two‐dimensional interpersonal circle, based on affiliation (AFF) and control (CON) as the underlying main dimensions. However, modern emotion theories distinguish three, rather than two, robust dimensions of emotional experience and the perception of interpersonal behaviours: (1) positive versus negative evaluation (related to AFF), (2) strong versus weak (related to CON) and (3) active versus passive (arousal). In a large Dutch patient sample (N = 1,001), we first tested whether the two‐dimensional circumplex structure of the IMI‐C could be replicated using Browne's circumplex model. Then we explored whether a third dimension could be retrieved from therapists' IMI‐C responses using exploratory factor analysis, followed by orthogonal target rotation towards a partially specified target matrix, with the first two factors specified according to the circumplex structure, and the other factor(s) left free. The two‐dimensional circumplex of the IMI‐C could be validated to a fair extent. Using exploratory factor models, we found supporting evidence for a third factor, which could be interpreted as reflecting reactance (‘active’ vs. ‘passive’ opposition). We recommend to extend the current two‐dimensional interpretation to a three‐dimensional interpretation of IMI‐C responses, by adding a reactance dimension.
Identification of new sources of Hessian fly resistance in tetraploid wheat
Authors: Nemacheck Jill A. , Flynn Rachel D. , Zapf Kathleen , Subramanyam Subhashree 
Published: January 2023

AbstractHessian fly (HF) (Mayetiola destructor Say) is an obligate destructive pest of wheat (Triticum aestivum L.) causing severe economic losses worldwide. Deployment of resistant wheat cultivars harboring HF resistance (H) genes is still the most effective and economical method to manage this insect pest. However, extensive use of H genes can impose selection pressure on HF populations, leading to the development of virulent biotypes that can breakdown plant resistance. Further, increase in environmental temperatures to 25–30°C during the wheat‐growing season can also negatively impact HF resistance, thereby necessitating the identification of new and novel sources of HF resistance and evaluate them for temperature sensitivity. In the current study, we evaluated the phenotypic response of 254 Triticum turgidum (L.) wheat accessions of African origin to Biotype L HF infestation. Of these, 10 accessions exhibited >70% resistance to Biotype L HF infestation. These 10 resistant accessions also showed >70% resistance when screened with vH13 HF biotype. Additionally, these HF resistant lines were evaluated for expression of resistance at a higher temperature of 30°C, and three tetraploid wheat accessions that maintained 100% resistance to Biotype L HF at the increased temperature were identified. These newly identified HF resistant lines offer valuable tools to breeders and farmers that can be used in breeding programs to develop cultivars for durable resistance to HF and efficient crop management.
A novel copper chelator for the suppression of colorectal cancer
Authors: Shi Xiaolong , Li Ying , Jia Mengting , Zhang Zhixin , Huang Lunhua , Zhang Miaomiao , Xun Qingqing , Jiang Di , Liu Yanrong 
Published: January 2023

AbstractCopper ions play a crucial role in the progression of cancers. Tumor tissue is rich in copper ions, and copper chelators could potentially scavenge these copper ions and thus exert an antitumor effect. In this study, we report the synthesis of a novel thieno[3,2‐c]pyridine compound we have called “JYFY‐001” that can act as the copper chelator thanks to the inclusion of an N‐(pyridin‐2‐yl)acetamide moiety that targets copper ions. JYFY‐001 potently inhibited cancer proliferation, inducing cell apoptosis and impairing the extracellular acidification rate and oxygen consumption rate of colorectal cancer (CRC) cells. JYFY‐001 also inhibited the growth of a CRC‐transplanted tumor in a dose‐dependent manner, inducing apoptosis of the tumor cells and promoting the infiltration of lymphocytes in the CRC‐transplanted tumor tissues. JYFY‐001 also enhanced the antitumor effects of the programmed cell death protein 1 (PD‐1) inhibitor. The relatively benign nature of JYFY‐001 was demonstrated by the effect on normal cell viability and acute toxicity tests in mice. Our findings suggest that JYFY‐001 is a prospective copper chelator to be used as a targeted drug and a synergist of immunotherapy for CRC treatments.
The duration of ketamine detection in hair after treatment cessation: Case study and review of the literature in forensic and clinical casework
Authors: Larabi I.‐A. , Etting I. , Alvarez J.‐C. 
Published: January 2023

AbstractThe disappearance of drug from hair does not occur immediately after abstinence because dormant hair may contribute to the positivity of freshly grown hair. The aim of this study was to assess ketamine disappearance from hair after treatment cessation and to review the literature data. A 22‐year‐old female received three intravenous doses of ketamine (171 mg) for major depression treatment. Seventeen weeks later, a 26 cm lock of hair was sampled, and ketamine was determined by liquid chromatography tandem mass spectrometry (LC–MS/MS) on seven segments: A (proximal, 0–2 cm), B (2–4 cm), C (4–6 cm, period of ketamine therapy), and D to G (4 × 5 cm). Ketamine concentration was 58 pg/mg in Segment C and remained detectable over 4 months after treatment cessation at 67 pg/mg in Segment B and 2 pg/mg in Segment A, representing a 97% drop from the initial concentration. Ketamine elimination half‐life in hair was estimated at 0.88 month, implying that indetectable concentration should be expected 7 months after cessation. Axial diffusion was excluded as ketamine was not detected in Segments D–G. Given the low ketamine concentrations, norketamine was not detected. While no data on ketamine disappearance from hair have been published to date, previous studies have shown that discontinuation resulted in negative hair results after 3 months for heroin, 3–4 months for cocaine and tramadol, 6 months for amphetamine and methamphetamine, and 6–7 months for THC‐COOH. This study provides useful findings for ketamine hair concentration interpretation, which should be validated by more consistent and comprehensive investigations.
Persistence and quality of vegetation cover in expired Conservation Reserve Program fields
Authors: Vandever Mark W. , Elgersma Kenneth , Carter Sarah K. , Wen Ai , Welty Justin L. , Arkle Robert S. , Assal Timothy J. , Pilliod David S. , Mushet David M. , Iovanna Rich 
Published: January 2023

AbstractFor nearly 40 years, the Conservation Reserve Program (CRP) has implemented practices to reduce soil erosion, improve water quality, and provide habitat for wildlife and pollinators on highly erodible cropland in the United States. However, an approximately 40,470 ha (10 million acres) decline in enrolled CRP land over the last decade has greatly reduced the program's environmental benefits. We sought to assess the program's enduring benefits in the central and western United States by (1) determining the proportion of fields that persist in CRP cover after contracts expired, (2) identifying the type of agricultural production that CRP fields shift to after contract expiration, (3) comparing the vegetation characteristics of expired CRP fields that are persisting in CRP‐type cover with enrolled CRP fields, and (4) identifying differences in management activities (e.g., haying, grazing) between expired and enrolled CRP fields. We conducted edge‐of‐field vegetation cover surveys in 1092 CRP fields with contracts that expired ≥3 years prior and 1786 currently enrolled CRP fields in 14 states. We found that 41% of expired CRP fields retained at least half of their area in CRP‐type cover, with significant variation in persistence among regions ranging from 19% to 84%. When expired fields retained CRP vegetation, bare ground was low in all regions and grass cover was somewhat greater than in fields with current CRP contracts, but at the expense of forb cover in some regions. Evidence of more frequent management in expired CRP fields may explain differences between active and expired CRP fields. Overall, there is clear evidence that CRP‐type cover frequently persists and provides benefits for more than three years after contract expiration. Retaining CRP‐type cover, post‐contract, is an under‐recognized program benefit that persists across the central and western United States long after the initial retirement from cropland.
Revealing large‐scale parasite ranges: An integrated spatiotemporal database and multisource analysis of the winter tick
Authors: Chenery Emily S. , Harms N. Jane , Fenton Heather , Mandrak Nicholas E. , Molnár Péter K. 
Published: January 2023

AbstractConcerns that climate warming may drive the spread of ectoparasites into previously uninhabited areas have increased the need for baseline knowledge of their distributional history. For species of wildlife health concern, presence data are often lacking or outdated, thus limiting our ability to assess range changes and subsequent host impacts. We reconstructed the past and present distribution of the winter tick, Dermacentor albipictus, through the compilation of a spatiotemporal database to create the first full baseline map of its occurrence throughout its North American range. The ongoing impacts of winter tick epizootics in moose (Alces alces) and recent mortality events in elk (Cervus canadensis) and white‐tailed deer (Odocoileus virginianus) have led to a resurgence in interest in the future of this parasite in a warming climate. Over 3400 unique records of winter tick occurrence were compiled from multiple data sources, dating from 1869 to 2020 and spanning from 16.5 to 66.2° N latitude. Both conventional published sources and natural history records were included along with new records from previously unpublished datasets and citizen science observations, to make this a comprehensive occurrence dataset for this species. Along with standardized location information and year of observation, the dataset includes associated host species and descriptive categorization of the type and source of each record, providing new opportunities to examine host–parasite interactions in the winter tick system over time and space. In presenting these data, we discuss the potential sampling biases and lacunas in our integrated database records, particularly at the winter tick's northernmost range. We also document changes in the types and sources of winter tick information from past to present, highlighting potential issues that should be considered before using these data in further analyses and when collecting ongoing records. Our database demonstrates that the collation and synthesis of records beyond conventional sources can shed light on the distributional history of tick species and serve as a useful baseline for prioritizing future research and management decisions.