bluuebunny/crossref_metadata_2025_split huggingface dataset:
Polysaccharide and Cyclodextrin-Based Monolithic Chiral Stationary
Phases and its Application to Chiral Separation
Authors: Aboul-Enein Hassan Y. , Kannappan Valliappan , Kanthiah Selvakumar 
Published: February 2023

Abstract:
The recent development of monolithic chiral stationary phases (CSPs) for liquid chromatography
(LC) is mainly focused on reducing backpressure, maximizing flow rates, faster run
time, column efficiency, and stability. This review paper emphasizes recent progress in the development
of polysaccharide and cyclodextrin-based monolithic CSPs. Further the paper draws attention
to competing techniques, like non-porous particle-packed columns, core-shell and monoliths
as chromatographic support matrix, available for achieving fast and efficient chromatographic separation.
A brief discussion on the three main classes of chiral monolithic stationary phase viz. silica,
organic polymer and hybrid-based monolithic stationary phases is also presented. In addition,
the paper highlights various studies on the application of monolith chiral CSPs in LC and capillary
electrochromrography separation and analysis of chiral compounds.
Revealing the Role of the Arg and Lys in Shifting Paradigm from BTK Selective Inhibition to the BTK/HCK Dual Inhibition - Delving into the Inhibitory Activity of KIN-8194 against BTK, and HCK in the Treatment of Mutated BTKCys481 Waldenström Macroglobulinemia: A Computational Approach
Authors: Elamin Ghazi , Aljoundi Aimen , Alahmdi Mohamed I. , Abo-Dya Nader E. , Soliman Mahmoud E.S. 
Published: February 2023

Background:
Despite the early success of Bruton's tyrosine kinase (BTK) inhibitors in the treatment of
Waldenström macroglobulinemia (WM), these single-target drug therapies have limitations in their clinical applications,
such as drug resistance. Several alternative strategies have been developed, including the use of dual inhibitors,
to maximize the therapeutic potential of these drugs.

Objective:
Recently, the pharmacological activity of KIN-8194 was repurposed to serve as a ‘dual-target’ inhibitor of
BTK and Hematopoietic Cell Kinase (HCK). However, the structural dual inhibitory mechanism remains unexplored,
hence the aim of this study.

Methods:
Conducting predictive pharmacokinetic profiling of KIN-8194, as well as demonstrating a comparative
structural mechanism of inhibition against the above-mentioned enzymes.

Results:
Our results revealed favourable binding affinities of -20.17 kcal/mol, and -35.82 kcal/mol for KIN-8194 towards
HCK and BTK, respectively. Catalytic residues Arg137/174 and Lys42/170 in BTK and Arg303 and
Lys75/173/244/247 in HCK were identified as crucial mediators of the dual binding mechanism of KIN-8194, corroborated
by high per-residue energy contributions and consistent high-affinity interactions of these residues. Prediction of
the pharmacokinetics and physicochemical properties of KIN-8194 further established its inhibitory potential, evidenced
by the favourable absorption, metabolism, excretion, and minimal toxicity properties. Structurally, KIN-8194
impacted the stability, flexibility, solvent-accessible surface area, and rigidity of BTK and HCK, characterized by
various alterations observed in the bound and unbound structures, which proved enough to disrupt their biological
function.

Conclusion:
These structural insights provided a baseline for the understanding of the dual inhibitory activity of KIN-
8194. Establishing the cruciality of the interactions between the KIN-8194 and Arg and Lys residues could guide the
structure-based design of novel dual BTK/HCK inhibitors with improved therapeutic activities.
A DMA-WSN Based Routing Strategy to Maximize Efficiency and Reliability
in a Ship to Communicate Data on Coronavirus
Authors: Sethi Deepak , Anand Jyoti , Shukla Meenu , Tripathi Ankita 
Published: February 2023

Background:
The Sensor Nodes (SNs) are deployed in an environment where human
beings are not able to perform the tasks. Wireless Sensor Network (WSN) is used for applications in
security, military surveillance, habitat monitoring, agriculture, etc. All these applications require
SNs to have good battery backup so that they can perform for a long duration. Recent research
shows that agent-based strategies increase the efficiency of WSN in comparison to conventional
WSN in which every SN is static. During the current pandemic of Covid-19, various public resources,
such as train, bus, hotels, etc., were used for isolating the Covid-19 patients. In a similar
way, the ship helps to keep humans away from each other.

Methods:
In the current work, WSN has been deployed on a ship to monitor the health of Covid-19
patients. A 109 m long ship with 12.8 m altitude and 23 m width along with 6 decks has been considered.
The SNs have been deployed on different floors of the modern ship. Six decks have been
considered, and on each deck, 50 SNs have been deployed. A Drone-driven Mobile Agent (DMA)
routing strategy has been proposed. DMA is a software program that moves across the network
around the SNs and collects information from wearable sensors, such as body temperature, SpO2,
etc. DMA is capable of aggregating and delivering the data packets to the base station for further
processing. DMA performs information processing, local processing, and collaborative signaling.
DMA can move randomly or in fixed locations.

Results:
Results have been compared with multi-sink and mobile sink strategies, which reveal that
the proposed and simulated technique enhances the life span and throughput of the network to monitor
Covid-19 patients effectively.

Conclusion:
Results revealed the proposed technique to enhance the lifetime (DMA-fixed: 11633
rounds and DMA-random: 11740 rounds) and throughput (DMA-fixed: 148788 packets sent and
DMA-random: 150008 packets sent) of the network.
Global Value Chains and the Slowing Down of Globalisation
Authors: Della Posta Pompeo 
Published: February 2023

Global value chains (GVCs) have been a major feature of the phase of economic globalisation that began after the 1980s. After the global financial crisis of 2007-08, however, this phase has come to an end, being replaced by one characterized by a significant slowdown in the degree of international economic openness, due to not only economic but also geopolitical reasons.. GVCs have also shown a slowing growth trend after then.
The future scenarios for GVCs, however, suggest the possibility that they may be more resilient than expected.
A first theoretical explanation provided in the literature argues that the reshoring of foreign intermediate production would be prevented by the high sunk costs that would have to be incurred.
However, an additional possible reason for GVCs resilience - this is the main theoretical contribution of this article - is due to the option of friendshoring or nearshoring, rather than reshoring. Moving the production to more suitable foreign destinations, characterized by a political or geographical proximity with the domestic one, would avoid the newly perceived strategic and geopolitical costs, while retaining the economic benefits of offshoring, thereby making GVCs resilient.
Effectiveness of pelvic rocking exercise on length and pain in delivery women: A Meta-Analysis
Authors: Navelia Zesika Intan , Kasjono Heru Subaris , Virahaju Mahindria Vici 
Published: February 2023

<p><strong><em>Background: </em></strong><em>Anxiety about prolonged and painful labor processes encourages the mother to do a section cesarean <em>( </em>SC ), which is becoming one of the indications SC incidents increase globally. Pelvic rocking exercise using a birth ball<em> </em>has several benefits in helping mothers give birth, especially in the first stage. The movement by sitting on the ball and rocking using gravity can increase the release of endorphins<em> </em>that provide comfort and enhance duration in labor.</em></p><p><strong><em>Objective</em></strong><strong><em>s</em></strong><strong><em>:</em></strong><em> To analyze the effectiveness of the pelvic rocking exercise<em> </em>using a birth ball<em> </em>on the duration of labor and reducing pain in the first stage of labor.</em></p><p><strong><em>Method</em></strong><strong><em>s</em></strong><strong><em>:</em></strong><em> A systematic review and meta-analysis<em> </em>by conducting an article search strategy using an electronic database according to the PICO method by eliminating articles according to the inclusion criteria includes articles with a period of 2011 – 2021, in Indonesian or English, using the RCT or Quasy experimental method, and the respondents used are pregnant women with gestational age of 30 weeks and above..</em></p><p><strong><em>Results: </em></strong><em>PRE using birth ball obtained statistically proven results to shorten the length and reduce labor pain than the control group. The experimental group had a significant effect in reducing labor duration and pain after intervention -1.13 [95% CI: -1.57, -0.09] p&lt;0.00001 and -1.19 [95% CI: -1.48, -0.90] p &lt;0.00001.</em></p><strong><em>Conclusions: </em></strong><em>There is an effect of pelvic rocking exercise using a birth ball on decreasing length of labor and pain in the first stage phase. It is expected that this research can be a complementary therapy option with good benefits and easy procedures for independent and collaborative midwifery practice in providing comprehensive midwifery care</em>
Analysis of the Factors Affecting the Household Income of Ethnic Groups in VoNhai District, Thai Nguyen Province
Authors: Chi Vu Thi Quynh , Nguyen Thai Thi Thai 
Published: February 2023

Ethnic groups by households in Vo Nhai District often inhabit in rural areas with low income and their life is much more difficult. Therefore, it’s necessary to study on the factors affecting their income in order to find a solution to improve their income. This research has used Cobb – Douglass Production Function, applying Stata software to evaluate the factors affecting household income of minorities. By collecting information from 310 households living in Vo Nhai district, Thai Nguyen province, Vietnam, the result of analysis showed that age of householder, cost, number of inhabitants in the family, level of education of the householders, employees, assets, land areas, bank loans which have an impact on the household income of ethnic groups. The study proposed solutions to help poor households expand on their production, improve their income, and enhance their living.
FAKTOR EKONOMI DAN DAMPAKNYA TERHADAP KASUS PERCERAIAN ERA PANDEMI COVID-19 DALAM TINJAUAN TAFSIR HUKUM KELUARGA ISLAM
Authors: Alghifari Abuzar , Sofiana Anis , Mas'ari Ahmad 
Published: February 2023

ABSTRAK: Pandemi Covid-19 sebagai persitiwa global memiliki dampak yang juga bersifat global. Tidak hanya dalam pengertian geografis namun juga pada praksis kehidupan. Berbagai negara dilanda pandemi lalu berdampak kepada banyak aspek tidak terkecuali perekonomian. Pandemi menimbulkan shock (guncangan) ekonomi dan mengakibatkan banyak keluarga yang mengalami kesulitan dalam memenuhi kebutuhan hidup. Tragisnya, tidak jarang ketika masalah ini tidak terselesaikan justru kehidupan rumah tangga itu sendiri yang diselesaikan dengan perceraian. Suatu fase dimana suami-istri seharusnya semakin mengencangkan kebersamaan agar mampu melewati pandemi dengan segala dampaknya ini. Tujuan penelitian ini untuk menelaah bagaimana tuntunan wahyu al-Qur’an dalam menyoroti kenyataan ini yaitu melalui perspektif tafsir hukum keluarga Islam.Penelitian ini menyimpulkan bahwa sakinah (ketenangan) merupakan tujuan mendasar dalam berpasang-pasangan. Sakinah tersebut merupakan hasil dari kolaborasi dua faktor utama, yaitu mawaddah (kecenderungan materialistik) dan rahmah (kecenderungan non-materialistik). Terganggunya perekonomian yang termasuk dalam kategori mawaddah, secara otomatis akan berpengaruh terhadap kualitas sakinah yang dihasilkan. Ketika kualitas sakinah terganggu akan menghasilkan goncangan terhadap eksistensi atau azwaja, yaitu hubungan keberpasangan. Sakinah akan mengalami fluktuasi disebabkan fluktuatifnya mawaddah dan rahmah itu sendiri. Karena itu, kedua faktor ini seharusnya mampu bekerja sama dan saling mengisi untuk mempertahankan eksistensi sakinah sehingga suami-istri terus mampu mempertahankan kebersamaannya. Dengan demikian, wahyu al-Qur’an menuntunkan bahwa terguncangnya aspek mawaddah, dalam hal ini adalah faktor ekonomi di era pandemi, tentu akan menyebabkan terguncangnya sakinah (ketenangan) dalam rumah tangga (azwaja). Dalam hal ini, aspek rahmah mesti hadir dan lebih diperkuat perannya untuk menjaga stabilitas sakinah sehingga kehidupan berpasangan (azwaja) mampu dipertahankan semaksimal mungkin dan perceraian menjadi tidak perlu terjadi.
Persepsi Pelaku Perceraian Terhadap Cerai di Luar Pengadilan Agama
Authors: Maliki Ibnu Akbar , Mualifah Lisna 
Published: February 2023

: Secara hukum, perceraian di Indonesia akan dianggap sah bilamana dilakukan melalui Pengadilan. Hal ini ditegaskan dalam Pasal 39 Ayat (1) Undang-Undang No.1 Tahun 1974 Tentang Perkawinan dan Pasal 115 Kompilasi Hukum Islam. Namun realitanya masih banyak terjadi praktik perceraian yang dilakukan di luar Pengadilan. Seperti halnya yang terjadi dalam masyarakat Kecamatan Way Serdang. Sebagian masyarakat masih enggan untuk melakukan perceraian di Pengadilan disebabkan kurangnya kesadaran hukum serta keyakinan masyarakat terhadap agama Islam yang tidak mengharuskan adanya prosedur perceraian sesuai yang diatur dalam Undang-Undang. Artikel ini membahas tentang persepsi pelaku perceraian tentang perceraian di luar Pengadilan Agama yang dilakukan masyarakat Kecamatan Way Serdang. Jenis penelitian ialah kualitatif deskriptif dengan pendekatan yuridis empiris. Data dikumpulkan dengan metode observasi dan wawancara. Hasil penelitian menunjukkan bahwa terdapat tiga praktik perceraian di luar Pengadilan Agama dalam masyarakat Kecamatan Way Serdang yakni melalui musyawarah keluarga, pengucapan talak/cerai yang disaksikan secara langsung oleh keluarga, dan melalui media telepon. Persepsi positif ditunjukkan oleh pelaku perceraian terhadap cerai di luar Pengadilan Agama, sedangkan persepsi negatif ditunjukkan terhadap cerai melalui Pengadilan Agama. Persepsi tersebut mereka tunjukkan baik dalam segi konsep hukumnya maupun dari praktis pelaksanannya.
Management Of Influencer Expression Regarding Vaccination Communication On Instagram
Authors: Kertamukti Rama 
Published: February 2023

Middle January 2021, the death toll related to the Covid-19 pandemic reached 2 million people, and nearly 26 thousand people were recorded in Indonesia. The struggle of the Indonesian government to reduce the number of victims of COVID-19 by bringing the Sinovac vaccine and vaccinations to the community. Pros and cons occur in response to the covid-19 Vaccination with this Sinovac vaccine. The government's public communication strategy through influencers with many followers on Instagram is an option. The election of Instagram as Social media for vaccination communication is because Instagram is the most up-to-date social media, and it is easy to provide understanding because it involves information in the form of visuals and text to the public. In carrying out vaccination communications, these influencers create messages or information that are organic or organic. Amplified Word of Mouth so that vaccination communication can reach the community simultaneously. The subjects studied in this study were influencer accounts (@arielnoah and @dr. Tirta) which were selected by purposive sampling with qualitative research using the literature review method. The results showed that the influencers in each post on vaccination communication activities in the form of distributing content and information in the feed room, likes, and giving comments showed that vaccination communication activities carried out identity politics. Influencers on Instagram understand health and responsibility. The results of this study provide an overview of how influencers on their Instagram carry out impression management to convince the public that vaccines are safe and try to refer to the government's public campaign regarding covid-19 Vaccination.
Does Gender Moderate The Association Of Dimensional Peer Pressure On Alcohol Use During Emerging Adulthood? A Multi-Group Analysis
Authors: Matlala Sibongile 
Published: February 2023

Peer pressure and alcohol use in tertiary institutions seems to remain a challenge amongst emerging adults. The study examined the moderating influence of gender on the association between dimensional peer pressure and alcohol consumption. A non-probability convenient sampling technique was employed. The sample consisted of 414 participants who were students recruited from 6 faculties. Data was collected using Peer Pressure Inventory (PPI) and Alcohol Use Dependence Identification Test (AUDIT) in an online platform. Data was analysed using the Statistical Package for the Social Sciences Version 25 (SPSS-25). Structural equation modelling was used to test assumptions. The was no gender difference in terms of the relationship between peer conformity and misconduct on alcohol use. Results indicated an increased family involvement whichpredicted lower alcohol consumption among females but not in males. School and peer involvements were not related to alcohol use in both gender. Family involvement against peer influence on the use of alcohol, may be a protective factor in females but not in males. Males were more likely to conform to peer pressure than females.
Key words: Peer pressure; Family involvement; Alcohol use; Gender; Moderation
AN ANALYSIS OF ENGLISH LEXICAL COLLOCATION IN TRANSACTIONAL SPEAKING AMONG STUDENTS OF ENGLISH EDUCATION DEPARTMENT AT ALAUDDIN STATE ISLAMIC UNIVERSITY OF MAKASSAR
Authors: Nawir Muhammad Syahruddin , Nur Nur Aliyah , Nurul Hidayah  
Published: February 2023

This study focused on the use of lexical collocations in transactional speaking
skills of final year students majoring in English. This study aimed to determine the
students ability in using lexical collocation and identifiy its type in their transactional
speaking. The study conducted in Alauddin State Islamic University of Makassar. The
subject of this study were the final year students of English Education Department.
These students can be categorized as the intermediate learners of English because they
took speaking lectures one to three. It was important for their collocational knowledge
to be native-like. This study used a qualitative method. Researcher used interview as
the data collection tool. Then, the researcher analysed the transcript of the interview.
In analysing, researcher determined the collocation words and the types too, used
Oxford online collocation dictionary to check whether the collocation were true or
not. The findings showed that the students used English lexical collocations in their
transactional speaking. Researcher found 179 English lexical collocations are used by
the students. 81 of those collocations are correct. Researcher also found that they used
four types from total 6 types (based on Benson&Ilson) of English lexical collocation
which they tend to use the type 1 than the other types. The study therefore suggested
that the teacher and students should more concerned about the collocational
knowledge in this case lexical collocation.
CORRELATION BETWEEN FATIGUE AND PHYSICAL ACTIVITY IN CHRONIC KIDNEY DISEASE PATIENTS EXPERIENCING HEMODIALYSIS THERAPY
Authors: Surya Putri Novita , Sugito Hariadji , Auliya Wanda Wandita  
Published: February 2023

Chronic kidney disease is a disease that results in a decrease in kidney function so that it cannot filter blood and the remains of the body's metabolism. One of the renal replacement therapies for patients with chronic kidney disease is haemodialysis therapy. Haemodialysis therapy is a kidney replacement therapy using a dialysis machine, this therapy has side effects, one of which is fatigue. This fatigue incident causes the patient's physical activity to be reduced or decreased. Physical activity is a movement or activity that requires energy, one of the factors that causes disruption of physical activity is fatigue. The purpose of this study was to determine the correlation between fatigue and physical activity in patients with chronic kidney disease experiencing haemodialysis therapy.
The method used in this study is a correlation study with research design cross sectional with a sample of 88 respondents with using a purposive sampling technique. Data collection using questionnaire FSS (Fatigue Severity Scale) and IPAQ (International Physical Activity Questionnaire). Data analysis using Chi-Square correlation test with SPSS 25 for windows.
The results showed that almost all of the respondents experienced fatigue as many as 62 respondents (70.5%) and have a low level of physical activity as many as 47 respondents (53.4%). After statistical analysis, the value of Pearson Chi-Square 51,983 with Asymptotic Significance (2-sided) 0.000 (<0.05) which means that there is a rejection of H0 and acceptance of Ha, so there is a significance. The correlation between fatigue and physical activity in chronic kidney disease patients experiencing haemodialysis therapy at the Blambangan Hospital, Banyuwangi 2022.
The level of fatigue experienced by respondents causes troubles in daily activities or physical activity of respondents experiencing therapy haemodialysis.
Legal Protection Against Peer-to-Peer Lending-Based Financial Technology Losses
Authors: Abdillah  , Sukmawati  , Syah Muhammad Fadly 
Published: February 2023

This article discusses the analysis of Islamic legal contracts and positive laws concerning the legal protection against financial technology losses based on peer-to-peer lending. This discussion is based on two raised subtopics namely 1) The importance of legal protection against the losses of the parties involved in this transaction and 2) The analysis regarding the contract used in this transaction, which is based on two perspectives, the Islamic legal contracts and positive law. Furthermore, this qualitative research uses a comparative approach. The data analyzed in this study were both primary and secondary. The primary and secondary data were collected from interviews conducted via different platforms with various related sources and from materials, such as journals, articles, and theses, respectively. The results of this study show the importance of legal protection for every party involved in peer-to-peer lending-based financial technology transactions. Some legal issues that have been frequently experienced, include defaults, misuse of personal data, and even the threat of terror received by debtors. Additionally, reviews regarding the contract in the transaction imposed by the organizer were based on 2 perspectives, namely Islamic law and positive law. The transaction process will only become illegal when it conflicts the Islamic laws with the elements of usury and interest in it. And based on the perspective of positive law itself, if there is a defect or anything contrary to decency or public order, the agreement or contract becomes null and void.