bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of the Covid-19 Pandemic on the Standing of Companies Listed on the Warsaw Stock Exchange
Authors: Jóźwicki Rafał 
Published: April 2023

Abstract

Objective
The impact of the Covid-19 pandemic can be observed in many aspects of the functioning of people, economic entities, organisations and countries. One of the areas where this phenomenon has left its mark remains the stock markets. Company listings are influenced by both investor emotions and the economic and financial condition of individual companies. The aim of this study is to assess the impact of the Covid-19 pandemic on individual industries represented by companies listed on the Warsaw Stock Exchange.

Methodology
In order to achieve this goal, an analysis was made of the value of changes in the so-called sector indices in the period from the beginning of 2020 to the end of the first half of 2022. This approach to the study will make it possible to determine which industries were most significantly affected by the economic change and what the nature of the possible change was. Quarterly data was used in the research.

Findings
The results obtained made it possible to note that among the thirteen analysed sectors, we can observe those that lost their value as a result of the Covid-19 pandemic (WIG-medicines, WIG-food, WIG-banks, WIG-clothing), but also those that significantly increased their value in the period under study (WIG-motorisation, WIG-construction, WIG-energy, WIG-IT).

Value Added
The study conducted will allow for a better understanding of how investors react to crisis events and how this translates into the listing of companies on the stock market.

Recommendations
The research results obtained require further analysis to establish deeper links between the Covid-19 pandemic and individual sectors of companies listed on the Warsaw Stock Exchange, which will be the subject of the author’s further studies.
HIV Infection in Sumadija District
Authors: Mihailovic Natasa , Uskokovic Nikola , Miljanovic Ana , Đorđevic Ivana Mitrovic 
Published: April 2023

Abstract
Serbia is one of the countries with a considerably low prevalence of HIV infection and small number of people who get tested. The aim of this paper is to assess the epidemiological situation of HIV infection in the Šumadija district based on the analysis of the work of voluntary confidential counselling and testing centre for HIV (DPST). Retrospective cohort study of users of the services of the DPST within the Institute of Public Health Kragujevac in a fiveyears period. The form for gathering the data of the clients who undergo HIV counselling is a research instrument. The statistical testing was performed by using the χ2 test, Student’s t-test and ANOVA. DPST services have been used by 1495 clients, 2/3 of which are men (71.6% p<0.01), average age 29.7 ± 10.6 years. There is an increasing trend in the number of users (y=33.3x+198.7, R 2 =0.54). Risky behaviour were: unprotected vaginal (39.3%) and oral sex (22.8%), in men also anal heterosexual (10.2%) and homosexual intercourse (11.7%). Men are significantly more likely to enter homosexual relationships (χ2 =141.59, df=3, p<0.01)), so the number of tested men is significantly higher (χ2 =14.27, df=3, p<0.05). Out of the 1,495 tested people, 12 users were HIV positive. They are all male and almost all have had homosexual relationships. The importance of known epidemiological situation of HIV infection through the work of DPST is reflected in the change of people’s knowledge and behaviour towards HIV and its development depends on the available resources.
Combination Treatment in Ulcerative Colitis using 5-Aminosalysilic Acid (5-ASA) and Polysaccharide Peptide of Indonesian Ganoderma lucidum Mycelium Extract
Authors: Simadibrata Marcellus , Rachman Aditya , Budimutiar Felix , Simadibrata Paulus , Abdullah Murdani , Haloho Raja Mangatur , Wijaya Anthony Eka , Bisuk Batara , Maharani Shabrina , Mustikarani Dewi , Simadibrata Daniel Martin , Sugita Peter 
Published: April 2023

Background: Inflammatory bowel disease (IBD) is idiopathic disease characterized by chronic inflammation of the gastrointestinal tract. Polysaccharide peptide of Ganoderma lucidum mycelium extract (PPGL) is considerably a good option for adjunctive therapy of IBD. This study aims to evaluate the benefit of PPGL in patients treated with 5-ASA.Method: A retrospective observational cohort study was conducted to examine the medical records of 124 ulcerative colitis patients. There were 80 patients in intervention group who were treated with a combination of 5-ASA and PPGL, and there were 44 patients in the control group who were treated with 5-ASA only. Clinical and laboratory endpoints were observed at the baseline and after 30, 60, and 90 days. Clinical endpoints included abdominal pain, bloody diarrhea, aphthous stomatitis, and polyarthritis; meanwhile, laboratory endpoints included hemoglobin level, ESR, CRP, fecal calprotectin, M2-pyruvate kinase (MP2K), fecal culture, C. difficile culture, and colonoscopy results. Clinical trials conducted after patient enrollment with registry number ClinicalTrials.gov NCT04029649.Results: On day-30 there was a significant difference between intervention group 45.6% and control group 2.3% in abdominal pain complaints (p 0.001). Moreover, laboratory parameters of fecal calprotectin (p 0.001), fecal MP2K (p = 0.015), and hemoglobin (p 0.001) were considerably better in intervention group on day-30. These differences were consistently found on day 60 and 90.Conclusion: The study implies potential correlation between PPGL administration and improvement of clinical and laboratory endpoints up to 90 days. A larger randomized, blinded, prospective study is required to confirm these effects in ulcerative colitis.
Effects of Continuous Positive Airway Pressure on Nonalcoholic Fatty Liver Disease in Patients with Obstructive Sleep Apnea: A Systematic Review
Authors: Tamin Susyana , Ardiantara Sabda , Rudiatmoko Diar Riyanti 
Published: April 2023

Background: Nonalcoholic fatty liver disease (NAFLD) is associated with obstructive sleep apnea (OSA). Continuous positive airway pressure (CPAP) is the first-line therapy for OSA. However, the effect of CPAP on NAFLD in patients with concomitant OSA is still unclear. This study aims to identify the use of CPAP on NAFLD in patients with OSA. Method: A systematic literature search was performed using particular keywords and medical subheadings in three journal databases: Cochrane, PubMed, and EBSCOhost. The results were screened and assessed using inclusion and exclusion criteria by three independent authors. The Randomized controlled trial (RCT) quality was evaluated with Jadad scale and the cohort studies quality was assessed with Newcastle-Ottawa quality assessment scale.Results: Two RCTs and three cohort studies were eligible to fulfil the inclusion criteria, consisting of 620 total patients. Two RCTs showed no statistically significant improvement after CPAP treatment in NAFLD based on intrahepatic triglyceride (measured by proton magnetic resonance spectroscopy), liver stiffness measurement, serum cytokeratin-18 fragment, and liver function blood test parameters. Meanwhile, 2 cohort studies in adults and 1 cohort study in children showed significant improvement in ALT, AST, and APRI. However, one cohort study showed no significant improvement in serum fibrosis markers and transient elastography measurement after CPAP treatment.Conclusion: CPAP might be beneficial in some patients with OSA to improve NAFLD, but further research that includes many subjects and longer duration of CPAP therapy is needed to confirm this result.
Partisipasi Masyarakat Dalam Pelaksanaan Program Keluarga Berencana (KB) di Desa Liku Kecamatan Samaturu Kabupaten Kolaka
Authors: Zahari Ahmad Farouq Mulku , Utomo Puji Prio , Asriana Yuli 
Published: April 2023

AbstractThe Family Planning Program (KB) is a real step from the government to regulate the ideal age for giving birth, regulate pregnancy, child birth spacing, and protection in accordance with reproductive rights in realizing a quality family. Liku Village is one of the villages in Samaturu District, Kolaka Regency which is the target of implementing the Family Planning Program. However, its implementation has not been going well in the community. This can be seen from the high number of babies born each year and the relatively close distance between births. This study aims to determine how community participation in the implementation of the Family Planning (KB) program in Liku Village and what factors influence it. The method in this study uses a qualitative approach with primary data and secondary data as data sources. Informants in this study were selected based on purposive sampling. The results showed that the level of community participation in the implementation of the Family Planning (KB) program in Liku Village was still low. The most dominant factor influencing community participation in the implementation of the Family Planning Program in Liku Village is the cultural factor adopted by the local community. AbstrakProgram Keluarga Berencana (KB) merupakan langkah nyata dari pemerintah untuk mengatur usia ideal dalam melahirkan, mengatur kehamilan, jarak kelahiran anak, dan perlindungan sesuai dengan hak reproduksi dalam mewujudkan keluarga yang berkualitas. Desa Liku merupakan salah satu Desa di Kecamatan Samaturu Kabupaten Kolaka yang menjadi sasaran dari penerapan Program Keluarga Berencana. Namun dalam implementasinya belum berjalan dengan baik di tengah masyarakat. Hal ini dapat dilihat dari angka kelahiran bayi setiap tahun yang cukup tinggi dan jarak kelahiran anak yang cukup dekat. Penelitian ini bertujuan untuk mengetahui bagaimana partisipasi masyarakat dalam pelaksanaan program Keluarga Berencana (KB) di Desa Liku serta faktor-faktor apa saja yang mempengaruhinya. Metode dalam penelitian ini menggunakan pendekatan kualitatif dengan data primer dan data sekunder sebagai sumber datanya. Informan dalam penelitian ini dipilih berdasarkan purposive sampling. Hasil penelitian menunjukkan bahwa tingkat partisipasi masyarakat dalam pelaksanaan program Keluarga Berencana (KB) di Desa Liku masih rendah. Adapun faktor yang paling dominan mempengaruhi partisipasi masyarakat dalam pelaksanaan Program Keluarga Berencana di Desa Liku adalah faktor adat istiadat yang dianut oleh masyarakat setempat.
Microbiological screening of compounds with potential anti-lep activity among new synthesis compounds of the pyrimidine series
Authors: Lutsenko A. V. , Yushin М. Yu. , Genatullina G. N. , Tyrkov A. G. , Ayupova A. K. , Saroyants L. V. , Starikova A. A. , Samotrueva M. A. 
Published: April 2023

Aim. To study the effect of new synthesized pyrimidine derivatives on the growth of Mycobacterium lufu (M. lufu) and Mycobacterium tuberculosis (M. tuberculosis) when cultivated on Shkolnikova's medium.Materials and methods. The objects of research were new synthesized derivatives of 6 samples of derivatives of pyrimidine - 5-(arylmethylidene)-2,4,6-pyrimidine-2,4,6(1H,3H,5H)-trions under laboratory codes TAG1, TAG2, TAG3, TAG4, TAG5, TAG6 and 7 samples of 5-(getarylmethylidene)-2,4,6-pyrimidine-2,4,6(1H, 3H, 5H)-trions under the laboratory codes TAG7, TAG8, TAG9, TAG10, TAG11, TAG12, TAG13. M. lufu and M. tuberculosisH37Rv strains were used as test cultures. The antimycobacterial activity of the studied compounds was studied by the method of serial dilutions.Research results. All studied compounds were found to exhibit antimycobacterial activity. The greatest inhibitory effect against M. lufu was noted for TAG1, TAG4, TAG7, TAG12, and TAG13, which was comparable to that of the reference drug dapsone. By the nature of the inhibitory effect on the growth of M. tuberculosis, the compounds under the laboratory codes TAG 1, TAG 4, TAG 7 and TAG13 were comparable to isoniazid, and the effect of the TAG3 compound was even slightly superior to the reference drug.Conclusion. Among the studied new synthesized pyrimidine derivatives, compounds under the laboratory codes TAG1, TAG4, TAG 7 and TAG13 have the most pronounced antimicrobial activity both against M. lufu and M. tuberculosis, which allows us to consider them as the most promising substances for further research on the search for antimycobacterial, including antileprosy drugs.
Study of radiation-induced pneumonitis after arc and static irradiation in lungs of rats
Authors: Pashkovskaya O. A. , Filatova N. A. , Dokuchaeva A. A. , Shigaev V. V. , Krasilnikov S. E. 
Published: April 2023

The clinical application of the results of the experimental radiotherapy on animals is currently not widely used. The research of radiation injuries after irradiation target in rat lungs using the image-guided platform SmART+ (Precision, North Branford, Conn., USA) is a pilot study for the establishment of an animal model of radiation-induced pulmonary toxicity.Aim: To define the typical doses and target volumes in rat lung to o serve radiation pneumonitis.Material and methods. Four groups of Wistar and Wag rats, distinguishing by age (10–16,5 months) and weight (350-850 g.), were studied. Dosimetric treatment plans were calculated prior to irradiation, using arc or static methods, doses (10–30 Gy), target lung volumes (0,045–1,24 cm3), localization (right or left, top or bottom). Dosimetric planning provides optimal radiation exposure to the target and controls organ at risk doses. Computer tomography (CT) scans were performed for 16 weeks to observe radiation pneumonitisResults. To obtain the rat lung density in Hounsfield units (HU), healthy animals were scanned, CT images were processed, and the mean and standard deviation were calculated. Lung density values of rats (control values) are 519.6 ± 46.2 (HU). Comparison of experimental data on irradiated animals and control values was carried out. As a result, the relationship of the target volume, the delivered dose and the survival rate of animals after irradiation was established. It was shown that the “mean value of lung density” could be used for quantitative analysis of lung injuries after irradiation.Conclusion. Typical doses and target volumes in rat lungs to observe radiation pneumonitis were obtained. Decreasing aeration of lung tissue was derived at delivered dose 16 Gy and irradiated target volume in lung at least 0.5 cm3 (8%).
Effects of a high-carbohydrate high-fat diet on liver morphology in young and old rats
Authors: Mustaﬁna L. R. , Logvinov S. V. , Bogdanova L. I. , Kurbatov B. K. 
Published: April 2023

The liver is a complex metabolic organ that, through the regulation of energy metabolism, maintains the homeostasis of the whole organism.Aim: To establish the morphological changes in hepatocytes and the expression of endothelial vascular factor in a high-carbohydrate high-fat diet (HCHFD) depending on age.Material and Methods. A histological study of the liver was carried out in four groups of male Wistar rats: 1st group – 5-month-old animals on a standard diet; 2nd group – 5-month-old animals on HCHFD for 90 days (from 2 months of age); 3rd group – 18-month-old animals on a standard diet; 4th group – 18-month-old animals on HCHFD for 90 days (from 15 months of age). Using morphometric methods, the specific volumes (%) of unchanged and binuclear hepatocytes, sinusoidal capillaries, inflammatory infiltrates, and foci of fibrosis in the liver were determined. The expression of vascular endothelial growth factor (VEGF) in endothelial cells and hepatocytes was evaluated by immunohistochemical method. The concentration of cholesterol and triglycerides was determined by the enzymatic colorimetric method in the blood serum and in the liver.Results. A morphological study revealed a significant expansion of sinusoidal capillaries in groups 2 and 4. A statistically significant increase in the specific volume of hepatocytes with vacuolar inclusions, binuclear hepatocytes, fibrous foci and small inflammatory infiltrates was detected in the 4th group. VEGF expression increased in hepatocytes of groups 2 and 4. Biochemical study found an increase in the concentration of triglycerides in the rats’ liver of the 4th group. Thus, HCHFD, despite the pronounced signs of regeneration, increased age-related changes in the liver of old rats.
The role of the hydrogen sulfide donor in adenosine diphosphate-induced platelet aggregation in patients with coronary heart disease
Authors: Petrova I. V. , Trubacheva O. A. , Birulina Ju. G. , Chumakova S. P. , Gusakova S. V. 
Published: April 2023

Introduction. Platelet activation is the initial stage of thrombotic complications in pathological conditions, primarily in atherosclerotic cardiovascular diseases. Endogenous hydrogen sulfide (H2S) is an antiplatelet agent, but the specific ways to realize its effects are not studied enoughAim: To study the effect of H2S on adenosine diphosphate (ADP)-induced platelet aggregation in patients with coronary heart disease (CHD) with blockers of Na+,K+,2Cl-cotransporter (NKCC), an anion exchanger, and a phosphodiesterase (PDE) inhibitor of cyclic nucleotides.Material and Methods. The study included 22 patients with CHD. The control group included 14 healthy volunteers. Platelet aggregation was determined by turbidimetric method. The degree of aggregation (%) and the size of aggregates (rel. units) were measured. ADP (2 μM) was an aggregation inductor. In some cases the incubation medium contained the hydrogen sulfide donor NaHS (1–100 μM) and aggregation modifierResults. The H2S donor at a concentration of 100 μM reduced the parameters of ADP-dependent platelet aggregation in healthy volunteers and increased it in patients with coronary artery disease. NKCC and anion exchanger blockers, as well as a PDE inhibitor, reduced ADP-dependent platelet aggregation in healthy volunteers. The combined action of these agents and NaHS enhanced the inhibitory effects of the applied modifiers. The results obtained for platelet aggregation in patients with coronary artery disease differed in different directionConclusion. The obtained data indicate that the antiaggregation effect of H2S is realized through the effect on the NKCC and anion exchanger, as well as due to the effect on the links of the signaling system mediated by cyclic nucleotides.
Influence of a high-carbohydrate high-fat diet on age-related changes in the myocardium in rats
Authors: Logvinov S. V. , Mustafina L. R. , Kurbatov B. K. , Sirotina M. A. , Gorbunov A. S. , Naryzhnaya N. V. 
Published: April 2023

The increase in cardiovascular diseases and metabolic disorders associated with longevity actualizes the study of the effect of high-calorie diets on heart aging.Aim: the experimental study of the effect of a high-carbohydrate hig -fat diet on the myocardium in young and old age.Material and Methods. A morphological study of the myocardium was carried out in four groups of male Wistar rats: group 1 - 150-day-old animals were kept on a standard diet; 2nd - 150 days, kept at a high-carbohydrate high-fat diet (HCHFD) for 90 days (from 60 days of age); 3rd - 540 days old, kept on a standard diet; 4th - 540 days old, kept at HCHFD for 90 days (from450 days of age). ELISA method in blood serum was used to determine the concentration of fibronectin, transforming growth factor beta-1, connective tissue growth factor.Results. In groups 2-4, leukostasis, focal lympho-monocytic infiltration of the myocardial stroma, an increase in the number of myocardial cells with karyopyknosis and edema of the perinuclear zone of the sarcoplasm, contracture disorders, and an increase in the specific volume of the connective tissue of the stroma were detected. The defeat of myocardial cells and fibrosis were most pronounced in group 4. HCHFD increased the concentration of fibronectin in animals in both age groups with predominance in group 4, caused a tendency to increase the content of transforming growth factor beta-1, connective tissue growth factor in blood serum. Thus, HCHFD accelerates and enhances age-related changes in the white rat myocardium.
Kajian Penerapan Kebijakan Kawasan Pertanian Pangan Berkelanjutan di Daerah Kota Bandung
Authors: Mahardika Galih , Syaodih Ernady , Chofyan Ivan 
Published: April 2023

Laju alih fungsi lahan pertanian menjadi lahan non pertanian di Kota Bandung semakin tinggi, yang tidak saja mengancam ketahanan pangan, tetapi juga mengakibatkan penurunan kualitas lingkungan. Menindaklajuti penerapan Undang Undang Nomor 41 tahun 2009 tentang Perlindungan Lahan Pertanian Pangan Berkelanjutan, perlu dibuat Kajian Penerapan Kebijakan Kawasan Pertanian Pangan Berkelanjutan (KP2B) di Daerah Kota (Studi Kasus: Kota Bandung). Arahan kebijakan KP2B Kota Bandung sudah terdapat Peraturan Daerah Nomor 18 Tahun 2011 Tentang Rencana Tata Ruang Wilayah Kota Bandung Tahun 2011-2031 yaitu mempertahankan kawasan pertanian tanaman pangan melalui intensifikasi lahan pertanian di 3 kecamatan. Namun belum eksplisit menyebutkan KP2B, detail lokasi dan luasannya baru berupa arahan kecamatan. Penelitian ini menggunakan metoda Analisa overlay dan SWOT. Dari hasil analisa overlay Kecamatan Mandalajati tidak dapat lagi dimasukan kedalam usulan KP2B karena sudah beralih fungsi menjadi Lahan Pemakaman. Lokasi KP2B yang sesuai dan dapat dipertahankan adalah yang berlokasi di Kecamatan Ujung Berung dan Kecamatan Cibiru. Diperlukan penetapan Kawasan pertanian pangan berkelanjutan (KP2B) secara eksplisit dalam batang tubuh maupun peta perda Revisi RTRW Kota Bandung agar memiliki kekuatan hukum.
KAJIAN TEKNIS BUDIDAYA IKAN KAKAP PUTIH (Lates calcarifer) DI BALAI PERIKANAN BUDIDAYA AIR PAYAU (BPBAP) SITUBONDO, KABUPATEN SITUBONDO, JAWA TIMUR
Authors: Astuti Endang Puji , A'yun Qurrota , Vitasari Arida , Sari Putri Desi Wulan 
Published: April 2023

White snapper (Lates calcarifer) is a marine fish that can be referred to as giant sea perch, sea bass, and barramundi. This fish is one of the fishery commodities that have many overseas enthusiasts. The characteristics of fish are that they are easy to cultivate because they grow relatively fast and can adapt well to the environment. However, in the process of cultivation, seeds have low susceptibility to diseases caused by environmental conditions. The solution to overcome this is to improve the quality of the parent and seed. Furthermore, the seeds are cultivated until they reach the consumption size to meet market needs. The purpose of writing this scientific article for street vendors is to find out the cultivation techniques of white snapper at the BPBAP Situbondo Fisheries Center, as well as the problems that occur during cultivation activities. The method used was the active participation method and observation. White snapper cultivationtechniques include broodstock maintenance, hatchery, and rearing, each of which consists of pond preparation, feeding, monitoring water quality, and monitoring pests and diseases. The results of observations obtained from parent-rearing activities were 79% FR, hatchery activities obtained 50% HR and 22% SR, and rearing activities with 0.10% SGR, 4.29 FCR, and 54.43% SR. The obstacle that occurs is the presence of human error in the hatchery unit due to delays in grading, causing low survival rates (SR) that do not meet the requirements. In addition, the rearing unit trash feed is not always available so it does not meet the requirements in the calculation of SR, SGR, and FCR.