bluuebunny/crossref_metadata_2025_split huggingface dataset:
Thermally insulating and fire‐retardant bio‐mimic structural composites with a negative Poisson's ratio for battery protection
Authors: Du Fengyin , Jin Zuquan , Yang Ruizhe , Hao Menglong , Wang Jiawei , Xu Gang , Zuo Wenqiang , Geng Zifan , Pan Hao , Li Tian , Zhang Wei , She Wei 
Published: March 2023

AbstractBattery safety has attracted considerable attention worldwide due to the rapid development of wearable electronics and the steady increase in the production and use of electric vehicles. As battery failures are often associated with mechanical‐thermal coupled behaviors, protective shielding materials with excellent mechanical robustness and flame‐retardant properties are highly desired to mitigate thermal runaway. However, most of the thermal insulating materials are not strong enough to protect batteries from mechanical abuse, which is one of the most critical scenarios with catastrophic consequences. Here, inspired by wood, we have developed an effective approach to engineer a hierarchical nanocomposite via self‐assembly of calcium silicate hydrate and polyvinyl alcohol polymer chains (referred as CSH wood). The versatile protective material CSH wood demonstrates an unprecedented combination of light weight (0.018 g cm−3), high stiffness (204 MPa in the axial direction), negative Poisson's ratio (−0.15), remarkable toughness (6.67 × 105 J m−3), superior thermal insulation (0.0204 W m−1 K−1 in the radial direction), and excellent fire retardancy (UL94‐V0). When applied as a protective cover or a protective layer within battery packages, the tough CSH wood can resist high‐impact load and block heat diffusion to block or delay the spread of fire, therefore significantly reducing the risk of property damage or bodily injuries caused by battery explosions. This work provides new pathways for fabricating advanced thermal insulating materials with large scalability and demonstrates great potential for the protection of electronic devices.
The significance of M1‐polarized CD163+ macrophages in acute graft‐versus‐host disease (GVHD): Possible mechanisms of GVHD in the development of skin lesions
Authors: Muto Yusuke , Fujimura Taku , Kambayashi Yumi , Ohuchi Kentaro , Lyu Chunbing , Terui Hitoshi , Mizuashi Masato , Aiba Setsuya , Asano Yoshihide 
Published: March 2023

AbstractObjectivesGraft‐versus‐host disease (GVHD) is an important complication of bone marrow transplantation. Recent reports suggest the significance of T‐cell subsets (Th1, Th17, and cytotoxic CD8+ T cells) as well as CD163+ macrophages in the development of cutaneous GVHD. CD163+ macrophages produce various chemokines to establish the immunological microenvironment following stimulation by stromal factors in lesional skin. Thus, the purpose of this study is to determine the main source of IFN‐inducible chemokines in the lesional skin of GVHD.MethodsWe employed immunohistochemical (IHC) staining for CD163 as well as interferon (IFN)‐inducible chemokines (CXCL9, CXCL10, CXCL11) to determine if the main source of IFN‐inducible chemokines in the lesional skin of GVHD was CD163+ macrophages. Moreover, we investigated the possible cytokine profiles of lesional skin in GVHD by evaluating phospho‐signal transducer and activator of transcription (pSTAT) expression in epidermal keratinocytes.ResultsImmunohistochemical staining of serial sections for CD163 revealed that CXCL9‐expressing cells, CXCL10‐expressing cells, and CXCL11‐expressing cells were detected in adjacent to CD163+ TAMs in the dermis. In contrast, there were no CCL17‐expressing cells or CCL22‐expressing cells in the dermis. The nuclei of epidermal keratinocytes in GVHD expressed pSTAT1, pSTAT3, and pSTAT5B.ConclusionsThe chemokine expression patterns on CD163+ macrophages matched the expected phosphorylation pattern of epidermal STATs. Our present study suggested that CD163 + macrophages may be a therapeutic target in GVHD.
Rapid Access to Polysubstituted Tetrahydrocarbazol‐4‐ones via Sequential Selective C—H Functionalization from N‐Nitrosoanilines
Authors: Li Chan , Yang Yanchen , Fang Feifei , Liu Chaoyi , Li Chunpu , Wang Dechuan , Liu Hong 
Published: March 2023

Comprehensive SummaryHerein, we have developed a strategy of Rh(III)‐catalyzed C—H activation of N‐nitrosoanilines and iodonium ylides to construct novel tetralydrocarbzol‐4‐one scaffolds, which provided valuable templates for sequential C—H functionalization such as alkylation, alkenylation, amidation and (hetero)arylation at C5‐position of tetralydrocarbzol‐4‐one with different coupling partners. Gram‐scale synthesis and further transformations of tetralydrocarbzol‐4‐one derivatives to Ondansetron and its analogues demonstrated the utility of this protocol, which enabled the concise and diverse construction of biologically active molecules.
Peanut allergy burden survey: Factors associated with health‐related quality of life in adolescents
Authors: McCann William A. , Nowak‐Wegrzyn Anna , Hass Steven L. , Huang Danmeng , Donelson Sarah M. 
Published: March 2023

AbstractBackgroundPatients with peanut allergy (PA) experience significant burden of illness, which impacts health‐related quality of life (HRQoL), particularly in adolescence. There is a paucity of research evaluating drivers of HRQoL scores.MethodsA prospective, online survey of adolescents with self‐reported, provider‐diagnosed PA completed from November 2018 to January 2019 was used to explore drivers of the real‐world impact of PA on HRQoL using the Pediatric Quality of Life Inventory 4.0 (PedsQL) and other measures. Univariate and multivariate analyses were used to identify potential factors associated with PedsQL scores and to understand the level of association.ResultsA total of 102 adolescents were included. The final model included 10 variables: race, reported strict peanut avoidance, satisfaction with prophylaxis, moderate‐to‐severe reaction within the past 12 months, touching peanut as cause of most severe reaction, fear of reaction, age, gender, comorbidities, and daily life limitations. In total, three items were shown to be strong predictors of the PedsQL total score including cause of severe reaction was touching peanut (yes), level of agreement with avoiding peanut (completely agree), and satisfaction with prophylaxis (not very much/not at all).ConclusionsThere is substantial heterogeneity in the impact of the burden of PA on PedsQL scores across patients. This indicates the importance of shared and individualized decision making for PA management to optimize outcomes and improve HRQoL.
Developing integrated care pathways for atopic dermatitis—Challenges and unmet needs
Authors: Zuberbier Torsten , Beck Lisa A. , Bedbrook Anna , de Bruin‐Weller Marjolein , Bousquet Jean , Cork Michael , Douladiris Nikolaos , Katoh Norito , Mortz Charlotte G. , Werfel Thomas , Wojciech Francuzik , Wollenberg Andreas , Siemens Kristina , Stevanovic Katarina , Worm Margitta ,   AD‐ICPs Working Group
Published: March 2023

AbstractBackgroundGA2LEN‐ADCARE is a branch of the largest multidisciplinary network of research centres and clinical care in allergy and asthma, GA2LEN, focussing on the field of atopic dermatitis (AD). AD is a chronic inflammatory skin disease with high burden and many comorbidities requiring different levels of treatment. The need for aligned information from all involved healthcare providers led to the discussion of an integrated care pathway (ICP) plan for AD patient care involving all stakeholders and considering the complexity and variability of the disease, with a particular focus placed on the large number of patients with milder forms of AD.MethodsThe GA2LEN ADCARE network and all stakeholders, abbreviated the AD‐ICPs working group, were involved in the discussion and preparation of the AD‐ICPs during a series of subgroup workshops and meetings in years 2020 and 2021.ResultsHere we discuss the unmet needs in AD, the methodology for devising an AD‐ICP and the ICP action plan.ConclusionThe GA2LEN ADCARE network has outlined the unmet needs in AD and provided an action plan for devising AD‐ICPs, considering the complexity and variability of the disease.
Influence of Adsorption of para‐Aminothiophenol on Trap States and Recombination Kinetics at Plasmonic Ag‐TiO2 Heterostructure Interfaces
Authors: Wang Dan , Liang Zhi‐Hao , Xiao Yuan‐Hui , Lin Jian‐De , Zhou Jian‐Zhang , Wu De‐Yin 
Published: March 2023

AbstractThe variation of trap states and the involving kinetics on the Ag‐TiO2 interfaces after the adsorption of reactant molecules were explored with the help of the combination of spectroscopic, electrochemical and photoelectrochemical methods by using para‐aminothiophenol (PATP) as a probe molecule. The results of photoluminescence spectroscopy and chronoamperometry revealed the distribution of trap states of Ag‐TiO2 heterostructures and the influence of PATP's adsorption. Kinetic measurements of open‐circuit photovoltage showed that the adsorption of PATP affects not only the electron lifetime (τn) but also the recombination mechanism of charge‐carrier on Ag‐TiO2 heterostructures. The analysis of the obtained effective recombination orders indicated that the charge‐carrier recombination on the Ag‐TiO2 electrode followed second‐order kinetics, while the one of the Ag‐TiO2/PATP electrode evolved from first‐order kinetics at first (at higher Voc) to second‐order kinetics (at lower Voc).
Spatiotemporally deciphering the mysterious mechanism of persistent HPV‐induced malignant transition and immune remodelling from HPV‐infected normal cervix, precancer to cervical cancer: Integrating single‐cell RNA‐sequencing and spatial transcriptome
Authors: Guo Chenyan , Qu Xinyu , Tang Xiaoyan , Song Yu , Wang Jue , Hua Keqin , Qiu Junjun 
Published: March 2023

AbstractBackgroundThe mechanism underlying cervical carcinogenesis that is mediated by persistent human papillomavirus (HPV) infection remains elusive.AimsHere, for the first time, we deciphered both the temporal transition and spatial distribution of cellular subsets during disease progression from normal cervix tissues to precursor lesions to cervical cancer.Materials & MethodsWe generated scRNA‐seq profiles and spatial transcriptomics data from nine patient samples, including two HPV‐negative normal, two HPV‐positive normal, two HPV‐positive HSIL and three HPV‐positive cancer samples.ResultsWe not only identified three ‘HPV‐related epithelial clusters’ that are unique to normal, high‐grade squamous intraepithelial lesions (HSIL) and cervical cancer tissues but also discovered node genes that potentially regulate disease progression. Moreover, we observed the gradual transition of multiple immune cells that exhibited positive immune responses, followed by dysregulation and exhaustion, and ultimately established an immune‐suppressive microenvironment during the malignant program. In addition, analysis of cellular interactions further verified that a ‘homeostasis‐balance‐malignancy’ change occurred within the cervical microenvironment during disease progression.DiscussionWe for the first time presented a spatiotemporal atlas that systematically described the cellular heterogeneity and spatial map along the four developmental steps of HPV‐related cervical oncogenesis, including normal, HPV‐positive normal, HSIL and cancer. We identified three unique HPV‐related clusters, discovered critical node genes that determined the cell fate and uncovered the immune remodeling during disease escalation.ConclusionTogether, these findings provided novel possibilities for accurate diagnosis, precise treatment and prognosis evaluation of patients with precancer and cervical cancer.
Effect of MHC and inbreeding on disassortative reproduction: A data revisit, extension and inclusion of fertilization in sand lizards
Authors: Bererhi Badreddine , Duchesne Pierre , Schwartz Tonia S. , Ujvari Beata , Wapstra Erik , Olsson Mats 
Published: March 2023

AbstractThe harmful effects of close inbreeding have been recognized for centuries and, with the rise of Mendelian genetics, was realized to be an effect of homozygosis. This historical background led to great interest in ways to quantify inbreeding, its depression effects on the phenotype and flow‐on effects on mate choice and other aspects of behavioral ecology. The mechanisms and cues used to avoid inbreeding are varied and include major histocompatibility complex (MHC) molecules and the peptides they transport as predictors of the degree of genetic relatedness. Here, we revisit and complement data from a Swedish population of sand lizards (Lacerta agilis) showing signs of inbreeding depression to assess the effects of genetic relatedness on pair formation in the wild. Parental pairs were less similar at the MHC than expected under random mating but mated at random with respect to microsatellite relatedness. MHC clustered in groups of RFLP bands but no partner preference was observed with respect to partner MHC cluster genotype. Male MHC band patterns were unrelated to their fertilization success in clutches selected for analysis on the basis of showing mixed paternity. Thus, our data suggest that MHC plays a role in pre‐copulatory, but not post‐copulatory partner association, suggesting that MHC is not the driver of fertilization bias and gamete recognition in sand lizards.
Role of priority effects in invasive plant species management: Early arrival of native seeds guarantees the containment of invasion by Giant ragweed
Authors: Byun Chaeho 
Published: March 2023

AbstractEmpirical evidence shows that early arrival of native species, which induces the priority effects, can contribute to invasive plant species containment. However, more systematic studies are required to test the applied relevance of the priority effect. This study therefore aimed at testing the priority effects generated by different sowing times of seeds of nine native species on one target invasive plant species, that is, Giant ragweed (Ambrosia trifida). This study hypothesized that, when sown earlier, some native species will be able to substantially contain A. trifida through resource preemption. An additive competition design was used to test the competitive effects of native species on A. trifida. Depending on the sowing times of native and invasive plant species, three priority treatments were conducted: all species sown at the same time (T1); native species sown 3 weeks before A. trifida (T2); and native species sown 6 weeks before A. trifida (T3). Priority effects created by all nine native species significantly affected the invasibility of A. trifida. The average value of the relative competition index (RCIavg) of A. trifida was the highest when native seeds were sown 6 weeks early and decreased with decreasing early sowing time of native plants. The species identity effect was not significant on RCIavg if natives were sown at the same time or 3 weeks earlier than A. trifida invasion, but it was significant (p = .0123) if they were sown 6 weeks earlier than A. trifida. Synthesis and applications. The findings of this study clearly show that native species, when sown early, provide strong competition and resist invasion through prior utilization of resources. The consideration of this knowledge might improve A. trifida invasion management practices.
Geographic variation in the altitudinal migration patterns, body size, oxidative status and exploratory behavior in a neotropical bird
Authors: Poblete Yanina , Contreras Carolina , Fernández Carolina , Flores Cristian R. , Vega Patricia , Ávila Miguel , Sabat Pablo 
Published: March 2023

AbstractTo cope with life in the mountains, populations of the same species can exhibit substantial variability in their altitudinal migration patterns and phenotypes in response to local weather conditions. Studying such variability can provide valuable insights into how local populations respond to environmental challenges, and this information can be useful for conservation efforts in mountain ecosystems. Here, we used δ2H values of feathers and blood to evaluate latitudinal variation in altitudinal migration patterns and its possible links with body size, oxidative status, and exploratory behavior in 72 individuals of rufous‐collared sparrow (Zonotrichia capensis) that breed at low and high elevations in the center (~33°) and south (~38°) of Chile. Our results show that both altitudinal migration patterns and oxidative status were significantly influenced by the latitude of breeding sites, while exploratory behavior was associated with elevation. Notably, we found that fast‐explorer birds inhabiting low elevations in central Chile displayed higher levels of oxidative damage than slow‐explorer birds. These outcomes underscore the possibility of local adaptations in response to diverse local environmental conditions in the Andes. We discuss the implications of latitude, elevation, and environmental temperature in shaping the observed patterns and highlight the significance of identifying local adaptations in mountain birds for better predicting their response to climate change and other challenges stemming from anthropogenic activities.
Prolonged opioid use after distal radius fracture
Authors: Larrosa Pardo Fabian , Bondesson Elisabeth , Petersson Ingemar F. , Schelin Maria E. C. , Jöud A. 
Published: March 2023

AbstractBackgroundProlonged opioid use (more than 90 days) after injury puts the patient at risk for adverse effects. We investigated the patterns of opioid prescription after distal radius fracture and the effect of pre‐ and post‐fracture factors on the risk for prolonged use.MethodsThis register‐based cohort study uses routinely collected health care data, including purchases of prescription opioids, in the county of Skåne, Sweden. 9369 adult patients with a radius fracture diagnosed 2015–2018 were followed for 1 year after fracture. We calculated proportions of patients with prolonged opioid use, both in total and according to different exposures. Using modified Poisson regression, we calculated adjusted risk ratios for the following exposures: previous opioid use, mental illness, consultation for pain, surgery for distal radius fracture and occupational/physical therapy after fracture.ResultsProlonged opioid use (4–6 months after fracture) was found in 664 (7.1%) of the patients. A previous, but discontinued, regular use of opioids up to 5 years before fracture increased the risk compared to opioid‐naïve patients. Both regular and non‐regular opioid use the year before fracture increased the risk. The risk was also higher for patients with mental illness, and those who were treated with surgery, we found no significant effect of pain consultation in previous year. Occupational/physical therapy lowered the risk for prolonged use.ConclusionConsidering history of mental illness and previous opioid use while promoting rehabilitation can be important to prevent prolonged opioid use after distal radius fracture.SignificanceWe show that a common injury such as distal radius fracture can be a gateway to prolonged opioid use, especially among patients with previous history of opioid use or mental illness. Importantly, previous opioid use as far back as 5 years earlier greatly increases the risk of regular use after the reintroduction of opioids. Considering past use is important when planning treatment with opioids. Occupational or physical therapy after injury is associated with lower risk of prolonged use and should be encouraged.
Advancing the operationalization of national policy styles
Authors: Zahariadis Nikolaos , Karokis‐Mavrikos Vassilis , Exadaktylos Theofanis , Kyriakidis Alexandros , Sparf Jörgen , Petridou Evangelia 
Published: March 2023

AbstractWhile national policy styles have (re)gained academic attention in recent comparative public policy work, the concept still needs a widely accepted operationalization that can allow the collection and analysis of data across contexts while steering away from construct validity threats. We build on Tosun and Howlett's (2022) work and employ a mixed‐methods approach, which relies on exploratory factor analysis and hierarchical cluster analysis. We put forth an operationalization, using Bertelsmann's Sustainable Governance Indicators (SGI) as proxies, that achieves conceptual clarity and distinctiveness, informational robustness, and statistical power. Ultimately, we construct two composite indicators—mode of problem‐solving and inclusiveness—calculate them in 41 countries and present policy style classifications based on their combinations. We report the distribution of countries across four policy styles (administrative, managerial, accommodative, adversarial) and conclude with an analysis of the clusters, assessments of robustness, and comparison with other national policy style classification schemes.
Three‐dimensional visualization experimental study on proppant transportation and placement in the Hi‐way channel hydraulic fracturing technique
Authors: Xiang Chuangang , Li Song 
Published: March 2023

AbstractThe pattern of placement of the proppant in the fracture determines the stimulation and success of the surgery. Using a three‐dimensional visual parallel plate fracture model capable of simulating fracture height, length, and variable fracture width, we experimentally investigate the impact of fiber loading, fracture fluid viscosity, sand concentration, pulse time, perforation pattern, and injection rate on proppant transport, placement pattern, and access rate. Experimentally and visually, the migration process and the morphology of the proppant placement in the fracture were assessed. The formation laws of stable support columns and well‐shaped high conductivity fracture channels in fractures have been elucidated. Experimental results show that increasing the fiber concentration improves the channel rate and the proppant mass is large and stable. The channel rate increases with the viscosity of the fracturing fluid, and it is difficult to form a perfect channel when the viscosity is small. If the constructive displacement is too slight or too large, it will not favor the formation of a Hi‐way channel in the fracture. The optimal design displacement is 4.5 m3/min. When the proppant concentration is low, the passage rate is large, but the stability of proppant mass is poor under the scour of large displacement, the conductivity is low under the high closure pressure, the proppant concentration is too high, the suspension is difficult, the settlement rate is large, and it is difficult to form a large passage. The current column and the passage rate are larger for pulse times of 15–20 s. Cluster perforations are better than large continuous perforations. The higher the number of clusters in the same number of holes, the higher the channel rate. The formation laws of stable support pillars and well‐shaped high conductivity fracture channels in fractures have been elucidated, which can be useful for efficient stimulation of oil and gas reservoirs.
A search optimized blockchain‐based verifiable searchable symmetric encryption framework
Authors: Han Mu , Wu Shuai 
Published: March 2023

SummaryOutsourcing storage and computation to cloud servers have become a trend. Although searchable symmetric encryption (SSE) had handled the data privacy issue caused by honest‐but‐curious servers, a semi‐honest server may return incomplete or incorrect results when users search for their encrypted data. To against such servers, scholars have recently used blockchain/Ethereum‐based SSE schemes which utilize the public, that is, active nodes, to verify the search process. However, the search operation in existing schemes is very expansive in terms of fee and time. In this paper, we propose a new blockchain‐based searchable encryption framework with search optimized, that is, free of charge, quicker, and more private, at the cost of some extra storage. Besides, we design a general and efficient verification algorithm for our framework, which makes the search verifiable. In addition, we deploy an instance of our framework on an official Ethereum test network, and the experimental results and evaluations demonstrate the advantage of our framework.