bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mechanical, degradation rate, and antibacterial properties of a collagen-chitosan/PVA composite nanofiber
Authors: Hartatiek  , Fathurochman Fadhil , Wuriantika Maulia Ingganis , Yudyanto  , Masruroh  , Djoko Herry Santjojo Dionysius Joseph , Nurhuda Muhammad 
Published: February 2023

Abstract
This study synthesized collagen-chitosan/PVA nanofiber composites using the electrospinning method. Characterizations included Fourier transform infrared spectroscopy (FTIR) and surface morphology using scanning electron microscopy (SEM). Investigations were carried out on tensile strength, degradation rate, and antibacterial test. It was found that the functional groups C–H, –OH, C–O, C–N, and N–H were suitable for PVA, collagen, and chitosan materials. The SEM showed that increasing the PVA composition caused a change in fiber diameter ranging from 34.64 to 71.63 nm. The tensile strength results show that the smallest nanofiber diameter has the highest ultimate strength value of 5.6 ± 0.4 MPa. In addition, it was found that the rate of degradation was directly proportional to the increase in concentration. Antibacterial activity test was carried out using two types of bacteria, namely gram-positive bacteria S. aureus and gram-negative bacteria E. coli. The results showed that the collagen-chitosan/PVA nanofiber composite had a diameter of antibacterial inhibition for E. coli and S. aureus bacteria, respectively.
Evaluating on-board kVCT- and MVCT-based dose calculation accuracy using a thorax phantom for helical tomotherapy treatments
Authors: Tegtmeier Riley C , Ferris William S , Chen Ruiming , Miller Jessica R , Bayouth John E , Culberson Wesley S 
Published: February 2023

Abstract

Purpose. To evaluate the impact of CT number calibration and imaging parameter selection on dose calculation accuracy relative to the CT planning process in thoracic treatments for on-board helical CT imaging systems used in helical tomotherapy. Methods and Materials. Direct CT number calibrations were performed with appropriate protocols for each imaging system using an electron density phantom. Large volume and SBRT treatment plans were simulated and optimized for planning CT scans of an anthropomorphic thorax phantom and transferred to registered kVCT and MVCT scans of the phantom as appropriate. Relevant DVH metrics and dose-difference maps were used to evaluate and compare dose calculation accuracy relative to the planning CT based on a variation in imaging parameters applied for the on-board systems. Results. For helical kVCT scans of the thorax phantom, median differences in DVH parameters for the large volume treatment plan were less than ±1% with dose to the target volume either over- or underestimated depending on the imaging parameters utilized for CT number calibration and thorax phantom acquisition. For the lung SBRT plan calculated on helical kVCT scans, median dose differences were up to –2.7% with a more noticeable dependence on parameter selection. For MVCT scans, median dose differences for the large volume plan were within +2% with dose to the target overestimated regardless of the imaging protocol. Conclusion. Accurate dose calculations (median errors of <±1%) using a thorax phantom simulating realistic patient geometry and scatter conditions can be achieved with images acquired with a helical kVCT system on a helical tomotherapy unit. This accuracy is considerably improved relative to that achieved with the MV-based approach. In a clinical setting, careful consideration should be made when selecting appropriate kVCT imaging parameters for this process as dose calculation accuracy was observed to vary with both parameter selection and treatment type.
Development of an ultra-low-cost planar biaxial tester for soft tissue characterization
Authors: Gupta Vivek , Gupta Shubham , Chanda Arnab 
Published: February 2023

Abstract
Nowadays, the research in the arena of biomedical engineering or specifically soft tissue characterization is rapidly increasing. Due to the complex properties of soft tissues such as, anisotropy and viscoelasticity, it is difficult to predict the deformation behaviour. Hence, soft tissue characterization is essential to analyze these metrics. Soft tissue characterization, specifically, can be done by implementing a planar biaxial tester. Currently, available biaxial testers are mostly developed with respect to other mechanical components such as metals, and not for the soft tissues. Also, these devices are very costly, which makes it difficult for the low and middle income countries to perform this characterization. To solve this problem, in this work, an extremely low-cost biaxial tester was designed and developed. The design of the biaxial tester was simple and modular to allow device modifications according to the applications. The device has a force capability of less than 0.4 kN and a variable speed of 18 mm min−1 to 300 mm min−1. The biaxial tester was validated using a standard test material with mechanical testing machine and was further tested on several wound geometries including circular, square, diamond shaped, L-Plasty, and elliptical. The developed fully automated device exhibited high accuracy with real-time monitoring. Furthermore, test results on the wounds showed the device’s capability to differentiate amongst the considered wound geometries. This device can be helpful to medical students and doctors in understanding the mechanical behaviour of soft tissues during injury induced damage, disease, wounds healing and also for plethora of applications such as expansion testing of skin grafts.
Organ absorbed doses in the IORT treatment of breast cancer with the INTRABEAM device: a Monte-Carlo study
Authors: Nasir Zulfa , Probst Luis , Schneider Frank , Clausen Sven , Bürgy Daniel , Glatting Gerhard , Nwankwo Obioma 
Published: February 2023

Abstract

Purpose: The current prescription and the assessment of the delivered absorbed dose in intraoperative radiation therapy (IORT) with the INTRABEAM system rely mainly on depth-dose measurements in water. The accuracy of this approach is limited because tissue heterogeneity is ignored. It is also difficult to accurately determine the dose delivered to the patient experimentally as the steep dose gradient is highly sensitive to geometric errors. Our goal is to determine the dose to the target volume and the organs at risk of a clinical breast cancer patient from treatment with the system. Methods: A homogeneous water-equivalent CT dataset was derived from the preoperative CT scan of a patient by setting all materials in the patient volume as water-equivalent. This homogeneous CT data represents the current assumption of a homogenous patient, while the original CT data is considered the ground truth. An in-house Monte Carlo algorithm was used to simulate the delivered dose in both setups for a prescribed treatment dose of 20 Gy to the surface of the 3.5 cm diameter spherical applicator. Results: The doses received by 2% (D2%) of the target volume for the homogeneous and heterogeneous geometries are 16.26 Gy and 9.33 Gy, respectively. The D2% for the heart are 0.035 Gy and 0.119 Gy for the homogeneous and heterogeneous geometries, respectively. This trend is also observed for the other organs at risk. Conclusions: The assumption of a homogeneous patient overestimates the dose to the target volume and underestimates the doses to the organs at risk.
Everyday Economic Justice
Authors: Walker Louise E. 
Published: February 2023

Abstract
This article examines economic justice in nineteenth-century Mexico City through analysis of small-claims conflicts—juicios verbales. After the promulgation of the 1812 Cádiz Constitution, this centuries-old tradition of judicial arbitration was shaped by liberal constitutionalism. A new class of officials, the alcaldes constitucionales, were elected by residents to decide cases. Cádiz liberalism inaugurated a new world. What happened when people faced a classic problem, when they did not pay their debts? Microeconomic history—the quantitative and qualitative study of the economic relationships, decisions, and actions of individuals, households, and small enterprises—exposes the workings of economic justice. From 1813 to 1863, tens of thousands of residents pressed their claims before magistrates. As this article shows, justice grounded in Cádiz liberalism was relatively effective for ordinary people and evinced a gender fairness. These small-claims conflicts might seem a petty world of negligible amounts and narrow-minded disputes, but analyzed together, they challenge conventional interpretations about institutional deficiency and historical underdevelopment. Cádiz liberalism established a judicial institution to protect property rights, especially for creditors, that enjoyed broad legitimacy.
Necrotizing Soft Tissue Infection Post VASER-Assisted Liposuction and Lipofilling: A Case Report
Authors: Ahmed Mohamed Badie , Shraim Bara A , Abuelgasim Mutaz , Hammouda Atalla 
Published: February 2023

Abstract
Liposuction is a very common aesthetic procedure nowadays. The complication rate is very minimal, and it increases relatively when combined with other procedures. Infection is an expected complication in liposuction and its risk is below 1% in isolated procedures. Although the risk is very low, it might lead to fatal consequences. In this manuscript, the authors present a previously healthy female who presented to the authors’ emergency department post-vibration amplification of sound energy at resonance (VASER)-assisted liposuction and lipofilling done in a private center. Her signs and symptoms started after the procedure and she visited the private center multiple times; however, no significant improvement was felt. Upon her presentation to the authors’ facility, immediate resuscitation was initiated, and she was admitted for further investigations and management. Despite all resuscitation efforts and interventions, the patient’s condition kept deteriorating. She was admitted to the surgical intensive care unit and taken to the operating theater twice with no observed significant improvement. The patient developed septic shock, a multiorgan failure state, followed by cardiac arrest. All resuscitation measures were taken, but the patient could not be revived and was declared dead. Early recognition of signs and symptoms of infection could be lifesaving. Aggressive resuscitation and surgical interventions (extensive debridement and antibiotics) might be necessary to produce successful outcomes.
Level of Evidence: 5
DeepPheWAS: an R package for phenotype generation and association analysis for phenome-wide association studies
Authors: Packer Richard J , Williams Alex T , Hennah William , Eisenberg Micaela T , Shrine Nick , Fawcett Katherine A , Pearson Willow , Guyatt Anna L , Edris Ahmed , Hollox Edward J , Marttila Mikko , Rao Balasubramanya S , Bratty John Raymond , Wain Louise V , Dudbridge Frank , Tobin Martin D 
Published: February 2023

AbstractSummaryDeepPheWAS is an R package for phenome-wide association studies that creates clinically curated composite phenotypes and integrates quantitative phenotypes from primary care data, longitudinal trajectories of quantitative measures, disease progression and drug response phenotypes. Tools are provided for efficient analysis of association with any genetic input, under any genetic model, with optional sex-stratified analysis, and for developing novel phenotypes.Availability and implementationThe DeepPheWAS R package is freely available under GNU general public licence v3.0 from at https://github.com/Richard-Packer/DeepPheWAS.Supplementary informationSupplementary data are available at Bioinformatics online.
Efficient estimation under data fusion
Authors: Li Sijia , Luedtke Alex 
Published: February 2023

Summary
We aim to make inferences about a smooth, finite-dimensional parameter by fusing together data from multiple sources. Previous works have studied the estimation of a variety of parameters in similar data fusion settings, including estimation of the average treatment effect and average reward under a policy, with the majority of them merging one historical data source with covariates, actions and rewards, and one data source of the same covariates. In this article, we consider the general case where one or more data sources align with each part of the distribution of the target population, such as the conditional distribution of the reward given actions and covariates. We describe potential gains in efficiency that can arise from fusing these data sources together in a single analysis, which we characterize by a reduction in the semiparametric efficiency bound. We also provide a general means of constructing estimators that achieve these bounds. Numerical simulations demonstrate marked improvements in efficiency from using the proposed estimators rather than their natural alternatives. Finally, we illustrate the magnitude of efficiency gains that can be realized in vaccine immunogenicity studies by fusing data from two HIV vaccine trials.
Molecular phylogenetics shed light on polyploid speciation in gorses (Ulex, Fabaceae: Genisteae) and on the origin of the invasive Ulex europaeus
Authors: Bellot Sidonie , Dias Paula M B , Affagard Marc , Aïnouche Malika-Lily , Misset Marie-Thérèse , Aïnouche Abdelkader 
Published: February 2023

Abstract
Hybridization and polyploidy are key evolutionary forces in plant diversification, and their co-occurrence in the context of allopolyploid speciation is often associated with increased ability to colonize new environments and invasiveness. In the genus Ulex (Fabaceae), the European gorse (Ulex europaeus subsp. europaeus) is the only invasive and the only polyploid that has recently spread in different eco-geographical regions across the world. Understanding what confers such ecological advantages to this species, compared to its diploid and polyploid congeners, first requires clarification of the ecogeographical and evolutionary context of its formation. To achieve this, the geographical distributions of all Ulex spp. were estimated from species occurrence records, and phylogenetic analyses including all Ulex spp. were performed based on four nuclear (ITS and ETS nrDNA) and plastid (rps12 intron and trnK-matK) regions. The resulting trees were dated using a secondary calibration. Patterns of DNA sequence variation and dated phylogenetic trees were then interpreted in light of previous knowledge of chromosome numbers in Ulex to infer past events of polyploid speciation in the genus. We show that: (1) most current Ulex spp. radiated in the Iberian Peninsula during the past 1–2 Myr; (2) the history of Ulex was punctuated by multiple whole-genome duplication events; and (3) U. europaeus subsp. europaeus is the only gorse taxon that was formed by hybridization of two well-differentiated lineages (which separated c. 5 Mya) with wide climatic ranges (currently represented by Ulex minor and Ulex europaeus subsp. latebracteatus), possibly contributing to the invasive nature and wider climatic range of U. europaeus subsp. europaeus. These findings provide a much-needed evolutionary framework in which to explore the adaptive consequences of genome mergers and duplication in Ulex.
Pathological changes in the brain after peripheral burns
Authors: Chen Jigang , Zhang Danfeng , Zhang Junhui , Wang Yanni 
Published: February 2023

Abstract
Brain injuries are common complications in patients with thermal burns and are associated with unpleasant outcomes. In clinical settings, it was once believed that brain injuries were not major pathological processes after burn, at least in part due to the unavailability of specific clinical manifestations. Burn-related brain injuries have been studied for more than a century, but the underlying pathophysiology has not been completely clarified. This article reviews the pathological changes in the brain following peripheral burns at the anatomical, histological, cytological, molecular and cognitive levels. Therapeutic indications based on brain injury as well as future directions for research have been summarized and proposed.
Estimating energetic intake for marine mammal bioenergetic models
Authors: Booth Cormac G , Guilpin Marie , Darias-O’Hara Aimee-Kate , Ransijn Janneke M , Ryder Megan , Rosen Dave , Pirotta Enrico , Smout Sophie , McHuron Elizabeth A , Nabe-Nielsen Jacob , Costa Daniel P 
Published: February 2023

AbstractBioenergetics is the study of how animals achieve energetic balance. Energetic balance results from the energetic expenditure of an individual and the energy they extract from their environment. Ingested energy depends on several extrinsic (e.g prey species, nutritional value and composition, prey density and availability) and intrinsic factors (e.g. foraging effort, success at catching prey, digestive processes and associated energy losses, and digestive capacity). While the focus in bioenergetic modelling is often on the energetic costs an animal incurs, the robust estimation of an individual’s energy intake is equally critical for producing meaningful predictions. Here, we review the components and processes that affect energy intake from ingested gross energy to biologically useful net energy (NE). The current state of knowledge of each parameter is reviewed, shedding light on research gaps to advance this field. The review highlighted that the foraging behaviour of many marine mammals is relatively well studied via biologging tags, with estimates of success rate typically assumed for most species. However, actual prey capture success rates are often only assumed, although we note studies that provide approaches for its estimation using current techniques. A comprehensive collation of the nutritional content of marine mammal prey species revealed a robust foundation from which prey quality (comprising prey species, size and energy density) can be assessed, though data remain unavailable for many prey species. Empirical information on various energy losses following ingestion of prey was unbalanced among marine mammal species, with considerably more literature available for pinnipeds. An increased understanding and accurate estimate of each of the components that comprise a species NE intake are an integral part of bioenergetics. Such models provide a key tool to investigate the effects of disturbance on marine mammals at an individual and population level and to support effective conservation and management.
Loperamide-induced cardiogenic syncope: a case report of a life-threatening presentation of an over-the-counter drug
Authors: Hegde Vishwajit , Dalia Tarun , Tayeb Taher , Cotter Elizabeth , Vidic Andrija 
Published: February 2023

AbstractBackgroundLoperamide at supratherapeutic doses can cause cardiac toxicity, presenting as cardiogenic shock, prolonged QT, malignant arrhythmias, or in severe cases sudden cardiac death. Surreptitious loperamide use is difficult to diagnose. We present an interesting case of loperamide use presenting with polymorphic ventricular tachycardia, cardiogenic shock.Case summaryA 25-year-old female presented with multiple syncopal episodes for 12 months with an electrocardiogram showing a Brugada-like pattern for which she underwent implantable cardioverter-defibrillator placement. One day following the procedure, she developed cardiogenic shock and was transferred to our tertiary care centre. Extensive workup was unrevealing. She responded well to supportive management, recovering from shock and was transferred to the floor. Unfortunately, she again developed cardiogenic shock, ultimately leading to cardiac arrest. Given the unclear cause for her cardiovascular symptoms, futher medication history was obtained. It was revealed that she was taking 100–150 tablets of loperamide per day. The decision was made to treat with intralipid emulsion therapy empirically given the strong suspicion for loperamide toxicity. The patient recovered well with supportive care. Loperamide levels returned elevated at 190 ng/mL. Repeated studies showed improvement of the conduction block, resolution of arrhythmias, and recovery of right and left ventricular function.DiscussionAcute loperamide toxicity can present as biventricular failure, with difficult-to-control arrhythmias. It requires a high index of suspicion. Treatment for loperamide toxicity is mainly supportive, lipid emulsion therapy can be considered in severe or refractory cases.
The pulmonary surgical Apgar score for lung cancer surgery predicts postoperative complications and long-term survival
Authors: Hino Haruaki , Hagihira Satoshi , Maru Natsumi , Utsumi Takahiro , Matsui Hiroshi , Taniguchi Yohei , Saito Tomohito , Murakawa Tomohiro 
Published: February 2023

AbstractOBJECTIVESThe surgical Apgar score, calculated using 3 intraoperative variables (blood loss, lowest mean arterial pressure and lowest heart rate), is associated with mortality in cancer surgery. The original score has less applicability in lung cancer surgery; therefore, we innovated the modified pulmonary surgical Apgar score with additional intraoperative oxygen saturation representing pulmonary parenchymal damage and cardiopulmonary dynamics.METHODSWe retrospectively analysed the data of 691 patients who underwent surgery for primary lung cancer between 2015 and 2019 at a single institute. We analysed the utility of the pulmonary surgical Apgar score compared with the original surgical Apgar score.RESULTSPostoperative complications were observed in 57 (8.2%) and 7 (1.0%) of the 691 patients who were stratified as grade ≥III and V, respectively, according to the Clavien–Dindo classification. We compared the fitness of the score in predicting postoperative complications; the calculated c-index (0.622) was slightly higher than the original c-index (0.604; P = 0.398). Patients were categorized into 3 groups based on their scores as follows: 0–6 points (n = 59), 7–9 points (n = 420) and 10–12 points (n = 212). Univariable and multivariable analyses demonstrated that a lower score was an independent negative risk factor for postoperative complications (odds ratio 3.53; P = 0.02). Patients with lower scores had a considerably poor 5-year overall survival (64.6%) (P = 0.07).CONCLUSIONSThe pulmonary surgical Apgar score predicts postoperative complications and long-term survival in patients with lung cancer undergoing surgery and may be utilized for postoperative management.