bluuebunny/crossref_metadata_2025_split huggingface dataset:
Supplementary Figure 2 from Metronomic Administration of Topotecan Alone and in Combination with Docetaxel Inhibits Epithelial–mesenchymal Transition in Aggressive Variant Prostate Cancers
Authors: Mitra Ghosh Taraswi , Mazumder Suman , Davis Joshua , Yadav Jyoti , Akinpelu Ayuba , Alnaim Ahmed , Kumar Harish , Waliagha Razan , Church Bird Allison E. , Rais-Bahrami Soroush , Bird R. Curtis , Mistriotis Panagiotis , Mishra Amarjit , Yates Clayton C. , Mitra Amit K. , Arnold Robert D. 
Published: July 2023

<p>Supplementary Fig. 2 shows Ingenuity pathway analysis (IPA) predictions for European American/ Caucasian American (EA/CA) ARHigh/mCSPC (LNCaP, VCAP, 22RV1), ARLow/mCRPC/NEPC (PC-3, PC-3M, DU145) and African American (AA) ARHigh/mCSPC (MDA-Pca-2b) PCa cell lines as well as normal prostate cell lines RWPE1 and RWPE2. IPA predicted A) Diseases and biological pathways for development of ARLow/mCRPC/NEPC. Major pathways are cell movement, morbidity, mortality, migration, invasion, survival, viability and development of vasculature- vasculogenesis and angiogenesis. B) Causal network pathway for development of ARLow/mCRPC/NEPC, which include oxidative phosphorylation, p70S6K, unfolded response, TREM1 signaling, NF-kB signaling, ERK5 signaling, IL-8 signaling, BAG2 signaling, Integrin signaling and VEGF signaling. C) IPA predicted HIF1α and EMT as key pathways associated with PCa development in African Americans (AA).</p>
Developmental changes in individual alpha frequency: Recording EEG
data during public engagement events
Authors: Turner Christopher , Baylan Satu , Bracco Martina , Cruz Gabriela , Hanzal Simon , Keime Marine , Kuye Isaac , McNeill Deborah , Ng Zika , van der Plas Mircea , Ruzzoli Manuela , Thut Gregor , Trajkovic Jelena , Veniero Domenica , Wale Sarah P. , Whear Sarah , Learmonth Gemma 
Published: July 2023

Abstract
Statistical power in cognitive neuroimaging experiments is often very low. Low sample size can reduce the likelihood of detecting real effects (false negatives) and increase the risk of detecting non-existing effects by chance (false positives). Here, we document our experience of leveraging a relatively unexplored method of collecting a large sample size for simple electroencephalography (EEG) studies: by recording EEG in the community during public engagement and outreach events. We collected data from 346 participants (189 females, age range 6-76 years) over 6 days, totalling 29 hours, at local science festivals. Alpha activity (6-15 Hz) was filtered from 30 seconds of signal, recorded from a single electrode placed between the occipital midline (Oz) and inion (Iz) while the participants rested with their eyes closed. A total of 289 good-quality datasets were obtained. Using this community-based approach, we were able to replicate controlled, lab-based findings: individual alpha frequency (IAF) increased during childhood, reaching a peak frequency of 10.28 Hz at 28.1 years old, and slowed again in middle and older age. Total alpha power decreased linearly, but the aperiodic-adjusted alpha power did not change over the lifespan. Aperiodic slopes and intercepts were highest in the youngest participants. There were no associations between these EEG indexes and self-reported fatigue, measured by the Multidimensional Fatigue Inventory. Finally, we present a set of important considerations for researchers who wish to collect EEG data within public engagement and outreach environments.
Assessment of a wearable fall prevention system at a veterans health administration hospital
Authors: Osborne Thomas F , Veigulis Zachary P , Arreola David M , Vrublevskiy Ilya , Suarez Paola , Curtin Catherine , Schalch Evann , Cabot Rachel C , Gant-Curtis Angela 
Published: July 2023

Objective In-hospital falls are a significant cause of morbidity and mortality. The Veterans Health Administration (VHA) has designated fall prevention as a major focus area. The objective of this report is to assess the performance of a new sensor-enabled wearable system to prevent patient falls. Methods An integrated sensor-enabled wearable SmartSock system was utilized to prevent falls at the acute care wards of a large VA hospital. Individual patients were only provided the SmartSocks when they were determined to be at high risk of falling. All fall count rates, with and without using the SmartSock, were evaluated and compared for individual patients. SmartSock sensor and electronic health record data were combined to assess the system's performance from February 10, 2021, through October 31, 2021. Results There were 20.7 falls per 1000 ward days of care (WDOC) for those not using the SmartSocks compared to 9.2 falls per 1000 WDOC for patients using the SmartSocks. This represents a reduction of falls by more than half. These findings are further confirmed with a negative binomial regression model, which showed the use of the SmartSock had a statistically significant effect on the rate of falls ( p = 0.03) when length of stay was held constant and demonstrated the odds of fall incident rate of 0.48 (95% CI, 0.24–0.92), that is less than half compared to when patients were not wearing the SmartSock. Conclusion The use of a sensor-enabled wearable SmartSock fall prevention system resulted in a clinically meaningful and statistically significant decrease in falls in the acute care setting.
Symbiotic propagation of Dendrobium bigibbum Lindl. with selected saprophytic Basidiomycota
Authors: BAUTISTA NONNATUS S. , VALENTINO MARY JHANE G. 
Published: July 2023

Abstract. Bautista NS, Valentino MJG. 2023. Symbiotic propagation of Dendrobium bigibbum Lindl. with selected saprophytic Basidiomycota. Biodiversitas 24: 3519-3527. Compatible mycorrhizal association of orchids with fungi is required for the germination and seedling development. In the present study, the mycorrhizal association of Dendrobium bigibbum with three species of saprophytic Basidiomycota, in particular, Volvariella volvacea, Lentinus tigrinus, and Pleurotus florida were evaluated. Co-culture technique was carried out during rhizoid and seedling development of D. bigibbum. Results revealed that the growth of D. bigibbum in rhizoid and seedling stages was enhanced when symbiotically grown with V. volvacea and L. tigrinus. D. bigibbum grown with V. volvacea had the highest mean length of the 1st leaf during the rhizoid stage. In seedling stage, V. volvacea and L. tigrinus significantly increased the growth of D. bigibbum in terms of length of 2nd leaf and fresh weight of the seedlings. For the length of root, increase in mean length was observed only in D. bigibbum co-cultured with L. tigrinus. In addition, the presence of peloton colonization was observed both in rhizoid and seedling stages. Thus, both V. volvacea and L. tigrinus formed compatible mycorrhizal association with D. bigibbum.
LA GESTIÓN ESTATAL DE LA DIVERSIDAD. ENFOQUE DIFERENCIAL EN LA POLÍTICA DE REPARACIÓN A LAS VÍCTIMAS AFROCOLOMBIANAS
Authors: Juan Pablo Estupiñán  
Published: July 2023

En este artículo analizo aspectos de la implementación de la política de reparación a víctimas afrocolombianas del conﬂicto armado. Propongo que la noción de enfoque diferencial constituye el campo jurídico-semántico en el cual se confgura la red de actores, relaciones sociales y sentidos que son disputados en torno a la política. A partir de relatos etnográfcos, analizo los actores y tensiones durante la implementación de la política en dos dimensiones: en el diseño institucional en el ámbito nacional, y en la puesta en marcha de la política en el nivel local. Concluyo reﬂexionado sobre el riesgo del enfoque diferencial de convertirse en un tecnicismo o en una meta institucional, perdiéndose sus fundamentos políticos de reconocimiento de derechos en medio de la burocracia estatal.
The role of sodium-glucose cotransporter type 2 inhibitors on the path to cardiovascular well-being in type 2 diabetes mellitus and chronic kidney disease
Authors: Demidova T. Yu. , Skuridina D. V. 
Published: July 2023

SGLT-2 inhibitors first emerged as a new class of oral hypoglycemic drugs with modest efficacy in lowering HbA 1c levels, which were also capable of inducing weight loss and lowering blood pressure without a significant risk of hypoglycemia. However, an analysis of the results of studies conducted to assess cardiovascular outcomes in patients with type 2 diabetes mellitus (DM) during iSGLT-2 therapy showed evidence of nephroprotection, which led to the initiation of trials on renal outcomes. The data obtained showed that the protective effects of iSGLT-2 against cardiovascular and renal complications of type 2 diabetes do not directly depend on their hypoglycemic activity, while their particular clinical significance is demonstrated in reducing the risk of hospitalization for heart failure (HF), progression of diabetic kidney disease (RDK), as well as a reduction in the incidence of major adverse cardiovascular events (MACE).Today it is known that against the background of diabetic nephropathy, cardiovascular consequences become more serious. CKD patients with diabetes are more likely to die from cardiovascular causes than from end-stage renal disease. Diabetic kidney disease appears to be not only a marker of increased cardiovascular risk, but also involved in the pathogenesis of cardiovascular disease. An increase in traditional risk factors such as hypertension, hyperlipidemia, and obesity cannot fully explain the worse cardiovascular and fatal outcomes in CKD.This review will focus on the role of iSGLT-2 in the outcomes of type 2 DM complicated by the development of CKD, and will highlight the putative mechanisms of the nephroprotective action of this group of drugs.
Pathology of carbohydrate metabolism in primary hyperparathyroidism: epidemiological and clinical characteristics
Authors: Bibik E. E. , Dobreva E. A. , Eremkina A. K. , Mokrysheva N. G. 
Published: July 2023

Primary hyperparathyroidism (PHPT) is characterized by disorders of not only mineral metabolism, but also other kinds of the human metabolism. Due to the increased frequency of cardiovascular risk factors among patients with PHPT, the study of the carbohydrate metabolism pathology in this cohort of patients will allow developing optimal approaches to their timely diagnosis and treatment.Aim. To determine the frequency and describe the clinical features of carbohydrate metabolism disorders in patients with PHPT.Material and methods. A single-center retrospective study of adults with PHPT was carried out with an assessment of the main parameters of mineral and carbohydrate metabolism before surgical treatment of the disease. The exclusion criteria were the absence of PHPT remission or a recurrence of the disease after parathyroidectomy; pregnancy, lactation. The frequency of various disorders of carbohydrate metabolism in PHPT, the comparative characteristics of mineral parameters in patients with and without them, as well as the severity of type 2 diabetes mellitus in PHPT were determined. In addition, potential relationships between the parameters of various types of metabolism have been studied.Results. The study was based on a clinical information of 367 patients with PHPT, most of whom had a symptomatic form of the disease. The overall incidence of prediabetic disorders was 4,9% (95% CI: 3-8). Type 2 diabetes mellitus was previously diagnosed in 45 patients (12%, 95% CI: 9-16), there were no cases of first diagnosed diabetes mellitus. Individuals with impaired carbohydrate metabolism had a statistically significantly higher body mass index and lower values of osteocalcin (27,2 [24,2; 30,4] kg/m2 vs 32,7 [28,1; 39,4 kg/m2 and 48,1 [34; 76,3] ng/mL vs 33,1 [20,8; 51,8] ng/mL, respectively, for all parameters p<0,001). Among patients with type 2 diabetes mellitus, 36 people (80%) took hypoglycemic therapy, 14 of which received metformin monotherapy and 8 received two-component therapy, including metformin. 5 people were on insulin therapy. Diabetic nephropathy was diagnosed in 36,4% of patients, 15,4% had signs of diabetic retinopathy, symptoms of diabetic distal neuropathy were observed in 61,9% of patients with PHPT. Fasting glucose and glycated hemoglobin were negatively correlated with bone metabolism, and also expectedly depended on the glomerular filtration rate.Conclusion. Among patients with PHPT, type 2 diabetes mellitus is more common than in the general population. The likely reason of this may be insulin resistance, that can be caused by the effects of bone metabolites, primarily osteocalcin. In most cases, metformin makes it possible to achieve compensation for diabetes mellitus in PHPT.
İşyerinde Hekimlere Yönelik Şiddetin Değerlendirilmesi ve Hekimler Üzerindeki Etkileri
Authors: Usluoğulları Fatih Hitami , Yurtseven Nurşen Turan 
Published: July 2023

Objective: One of the biggest problems that physicians face in their work life is the violence that they are exposed to. This study aims to determine the frequency and characteristics of the violence experienced by physicians in the workplace and to determine how the exposure to violence affects physicians’ job satisfaction, suicide risk, burnout levels.
Methods: This study is a cross-sectional study with descriptive characteristics. Four hundred-eighteen volunteer physicians participated. The questionnaires distributed to the participants were reviewed with the literature and consisted of sociodemographic information, questions about violence, Minnesota Job Satisfaction Scale, Suicide Probability Scale, Maslach Burnout Scale.
Results: It was observed that 58.4% of physicians were exposed to workplace violence during the last year and there was a significant difference in terms of gender, age, title, institution, duration of work and department. Physicians who suffered violence in the workplace during the last year; emotional exhaustion, insensitivity and suicide probability levels were higher, job satisfaction and personal success levels were lower than physicians who didn’t suffer.
Conclusion: In order to prevent violence against health workers and physicians and to reduce their possible effects, changes in the health policies implemented, improvement of working conditions, reorganization of the health environment, especially in emergencies, and a deterrent law that the Turkish Medical Association has been expressing for years should be enacted.
Effects of adsorption and filtration processes on greywater microbiological contamination and the potential human health risk reduction
Authors: Mortula Md Maruf , Fattah Kazi Parvez , Iqbal Fatima , Khan Zahid 
Published: July 2023

Abstract
Recycling treated greywater (GW) for onsite, non-potable applications can reduce the potable water demand typically used for non-potable purposes. The conventional methods for GW treatment are limited in their ability to remove wide-ranging pollutants in ways that are inexpensive and use low energy. For this reason, effective and low-cost onsite treatment options are in demand. This study examines the effectiveness of sand filtration (SF), granulated blast furnace slag (GBFS), and activated carbon (AC) in the treatment of GW from a residential apartment building in Sharjah, United Arab Emirates. The study relies on four different pilot-scale experimental setups to investigate the effectiveness of SF, AC, and GBFS in treating microorganisms from GW and evaluate the microbial risk reduction using these treatment processes. A quantitative microbial risk assessment (QMRA) approach is used for risk assessment. Results show that GBFS achieves a higher reduction of total coliform (TC) (0.54–2.05 log removal) and fecal coliform (FC) (1.96–2.30 log removal) than AC. SF improves reduction by 0.13–3.39 log removal and 1.11–3.68 log removal for TC and FC, respectively. The study also reveals substantial FC and Escherichia coli risk reduction by SF, AC and GBFS.
Clinical Applications of Sunscreens and Formulation Advancements
Authors: Sunena  , Tomar Deepali , Jawla Sunil 
Published: July 2023

Abstract:
Sunscreens cover the big market ratio in terms of cosmetic applications, but the therapeutic
necessity of sunscreen still needs to be uncovered in the clinical context. Clinically, sunscreens
are being employed more often nowadays as a result of the rising consequences of skin
malignancies and the photodamaging effects of UV radiation. Sunscreens are essential to prevent
aging by shielding the skin from the harmful effects of ultraviolet (UV) radiation. Over the recent
decades, there has been a significant evolution in the usage of sunscreens as photo protectants.
The demand for sunscreen formulations will inevitably rise as more people become aware of the
protection that sunscreens provide against tanning, photoaging, non-melanoma skin cancers, premalignant
skin lesions, and skin melanomas. The novel contemporary formulation techniques are
also beneficial in enhancing the product's aesthetic look and quality. Recently, regulatory agencies
have also started paying attention to the regulation of the clinical application, efficacy, and safety
parameters related to sunscreen. This review underlines the pathophysiological response of UV
exposure with the therapeutic applications of sunscreen in various dermatological conditions and
the recent formulation advancements in the development of sunscreen.
The Implementation of Scientific Approach to Increase Mathematics Understanding Ability on Algebraic Derivative Materials
Authors: Fathurrohman Muhamad Taufik , Sugandi Asep Ikin 
Published: July 2023

Referring to the objectives of learning mathematics and NCTM, one of the abilities that must be developed is the ability to understand mathematics. The importance of having the ability to understand mathematics includes this ability listed in the learning of mathematics in the 2006 KTSP mathematics curriculum and the 2013 curriculum. This study aims to examine the increased understandingÂ Â of the material concept of derivatives of algebraic functions in class XI high school students. This type of research is classroom action research. This research was conducted on class XI high school students for the 2020/2021 academic year, consisting of 16 students. The instrument used is a test of students' mathematical understanding abilities, in the form of 6 questions that focus more on students' understanding abilities regarding the derivative of algebraic functions; observation sheet for teachers and students to see the condition of the implementation of the action. This study shows that students' mathematical understanding abilities have increased as seen from the questions tested on each test with an increase in mastery from initially 31.25% to 56.25%. The results of this study indicate that the application of a scientific approach can improve the comprehension skills of class XI students on material derived from algebraic functions.
Perspektywy rozwoju polskiego rolnictwa w świetle proponowanego kształtu WPR 2014-2020
Authors: Wieliczko Barbara 
Published: July 2023

Propozycje przedłożone przez Komisję Europejską w 2011 r. w odniesieniu do kształtu Wspólnej Polityki Rolnej 2014-2020 sugerują, iż charakter tej polityki nie ulegnie zasadniczym zmianom. Oznacza to, iż w dalszym ciągu WPR nie będzie oferowała wystarczająco efektywnych i skutecznych instrumentów wspierania przemian strukturalnych w polskim rolnictwie. Szczególnie niepokojące, nie tylko z punktu widzenia polskiego rolnictwa, ale również w odniesieniu do konkurencyjności sektora rolnego całej Wspólnoty, są propozycje dotyczące zazielenienia płatności bezpośrednich. Podniesienie zobowiązań związanych z ochroną środowiska oraz wprowadzenie wymogów oznaczających de facto konieczność odłogowania 7% UR gospodarstwa rolnego może znacząco zmniejszyć konkurencyjność unijnego rolnictwa, którą już teraz systematycznie ograniczają wysokie koszty produkcji, wynikające zarówno z kosztów pracy, jak również z konieczności ponoszenia kosztów dotyczących przestrzegania norm i ograniczeń w zakresie środowiska naturalnego i dobrostanu zwierząt.
The Influence of Ecoenvironment Factors on the Development of Skiing
Authors: Zhang Xiao 
Published: July 2023

Abstract
Skiing depends on the external environment, in which material, energy and information are frequently exchanged, and this external environment greatly affects the quality of skiing’s existence. In this article, an ecosystem assessment algorithm based on ANN (Artificial Neural Network) is put forward. Based on this, a skiing development model under the influence of ecosystem factors is constructed to explore the influence of ecosystem factors on skiing development. The simulation results show that after many iterations, the error of this method is better than that of the comparison algorithm in ecosystem analysis, with the error reduced by 28.17 % and the recall rate reaching 94.65 %, which is improved by 16.88 % compared with the comparison algorithm. Therefore, this model can provide theoretical support for studying the influence of ecological and environmental factors on the growth of skiing. Based on the analysis of the characteristics of the regional landscape ecosystem, the eco-environmental impact assessment of the ski resort project predicts the impact of project construction on the regional landscape ecosystem. It explores ways and means to maintain the ecological integrity of the natural system to carry out project construction on the premise of protecting the local ecosystem and building a natural and artificial composite landscape ecosystem with reasonable structure and high efficiency.