bluuebunny/crossref_metadata_2025_split huggingface dataset:
Harnessing genetic variations improving seedling vigor for successful crop establishment in deep sown direct-seeded rice
Authors: Sandhu Nitika , Ankush Ade Pooja , Singh Jasneet , Raigar Om Prakash , Bains Sutej , Jindal Taveena , Singh Mohini Prabha , Sethi Mehak , Pruthi Gomsie , Augustine Gaurav , Verma Vikas Kumar , Goyal Shivani , Kumar Aman , Panwar Harsh , Sihag Manvesh Kumar , Kaur Rupinder , Kurup Smita , Kumar Arvind 
Published: March 2023

AbstractImproving seedling vigour remains key objective for breeders working with direct-seeded rice (DSR). To understand the genetic control of seedling vigour in deep sown DSR, combined genome-wide association mapping, linkage mapping, fine mapping, RNA-sequencing to identify candidate genes and validation of putative candidate genes was performed. Significant phenotypic variations were observed among genotypes in both F3:4:5and BC2F2:3populations. The mesocotyl length showed significant positive correlation with %germination, root and shoot length. The 3.79 Mb region on chromosome 7 reported to be associated with mesocotyl elongation. RNA-seq data and RT-PCR results identified and validated seven potential candidate genes. The potential candidate gene,LOC_Os07g25150codes forMyb-30-related transcription factor. TheLOC_Os07g25150codes forMyb 30-related transcription factor,LOC_Os07g17689annotated as protein translation factor,LOC_Os07g17770as tryptophanyl-tRNA synthetase,LOC_Os07g15440as alanyl-tRNA synthetase family protein,LOC_Os07g24100as retrotransposon protein and the remaining others as expressed proteins. The antagonistic relationship betweenMyb-30and ethylene-mediated signalling (EIN-3) in regulating mesocotyl elongation have been observed. The functional characterization and knocking ofLOC_Os07g25150codes forMyb 30-related transcription factor may provide better understanding of the mechanism behind mesocotyl elongation. The four promising introgression lines with longer mesocotyl length, longer root length and semi-dwarf plant height have been identified.
The Transcriptional Regulator Ume6 is a Major Driver of Early Gene Expression during Gametogenesis
Authors: Harris Anthony , Ünal Elçin 
Published: March 2023

ABSTRACTThe process of gametogenesis is orchestrated by a dynamic program of gene expression, where a vital subset constitutes the early meiotic genes (EMGs). In budding yeast, the transcription factor Ume6 represses EMG expression during mitosis. However, during mitosis to meiosis transition, EMGs are activated in response to the meiotic regulator Ime1 through its interaction with Ume6. While it is known that binding of Ime1 to Ume6 promotes EMG expression, the mechanism of EMG activation remains elusive. Two competing models have been proposed whereby Ime1 either forms a coactivator complex with Ume6 or promotes Ume6 degradation. Here, we resolve this controversy. First, we identify the set of genes that are directly regulated by Ume6, includingUME6itself. While Ume6 levels increase in response to Ime1, Ume6 degradation occurs much later in meiosis. Importantly, we found that depletion of Ume6 shortly before meiotic entry is detrimental to EMG activation and gamete formation, whereas tethering of Ume6 to a heterologous activation domain is sufficient to trigger EMG expression and produce viable gametes in the absence of Ime1. We conclude that Ime1 and Ume6 function as a coactivator complex. While Ume6 is indispensable for EMG expression, Ime1 primarily serves as a transactivator for Ume6.
Mapping AML heterogeneity – multi-cohort transcriptomic analysis identifies novel clusters and divergent ex-vivo drug responses
Authors: Severens Jeppe F , Karakaslar E Onur , van der Reijden Bert A , Sánchez-López Elena , van den Berg Redmar R , Halkes Constantijn JM , van Balen Peter , Veelken Hendrik , Reinders Marcel JT , Griffioen Marieke , van den Akker Erik B 
Published: March 2023

AbstractSubtyping of acute myeloid leukaemia (AML) is predominantly based on recurrent genetic abnormalities, but recent literature indicates that transcriptomic phenotyping holds immense potential to further refine AML classification. Here we integrated five AML transcriptomic datasets with corresponding genetic information to provide an overview (n=1224) of the transcriptomic AML landscape. Consensus clustering identified 17 robust patient clusters which improved identification ofCEBPA-mutated patients with favourable outcomes, and uncovered transcriptomic subtypes forKMT2Arearrangements (2),NPM1mutations (5), and AML with myelodysplasia-related changes (AML-MRC) (5). Transcriptomic subtypes ofKMT2A,NPM1and AML-MRC showed distinct mutational profiles, cell type differentiation arrests and immune properties, suggesting differences in underlying disease biology. Moreover, our transcriptomic clusters show differences in ex-vivo drug responses, even when corrected for differentiation arrest and superiorly capture differences in drug response compared to genetic classification. In conclusion, our findings underscore the importance of transcriptomics in AML subtyping and offer a basis for future research and personalised treatment strategies. Our transcriptomic compendium is publicly available and we supply an R package to project clusters to new transcriptomic studies.
All's (not) fair in motherhood and work? Post-partum psychological contract breach experiences of Indian first-time mothers
Authors: Varma Aparna M. , Sivarajan Rahul 
Published: March 2023

PurposeTo understand how Indian first-time mothers in STEM (Science, Technology, Engineering and Math) organisations returning to work cope with the perceived ideological psychological contract breaches from a work–home resources perspective.Design/methodology/approachThis paper utilises interpretative phenomenological analysis (IPA) within the work–home resources (W-HR) model to analyse returning first-time mothers' lived experiences.FindingsThis study shows that significant life/work events such as childbirth/lack of career growth can trigger resource depletion at work and home and materialise in first-time mothers perceiving ideological psychological contract breaches at work. It has also been observed that key resource usage and macro support structures aid employees in attenuating work–home conflict by balancing contextual demands and personal resources. This study's participant accounts reveal that the recovery of volatile resources was possible by psychologically detaching and being silent.Originality/valueThe study offers a distinctive perspective by investigating the ideological PC breach experienced by first-time Indian mothers upon their organisational re-entry from a work–home resource model lens. Situated in a unique socio-cultural space and bringing forth the rich lived experiences of women working in the Indian STEM field, this paper explores how key resources shape the coping responses of first-time mothers in this context.
How and when creativity thrives in construction projects: a study of leader's humor
Authors: Siddiquei Ahmad Nabeel , Ahmad Saima , Badar Kamal , Asmi Fahad 
Published: March 2023

PurposeThe present study aims to advance a new framework to spur creativity at individual and team levels in the construction industry by studying a leader's sense of humor. The authors develop and test a multi-level model to investigate the direct and indirect effects of leader's humor on creativity within teams working on construction projects. The authors draw on the benign violation theory to hypothesize that a leader's sense of humor influences the acceptability of norm violations in teams, which helps to improve their creativity. The authors also integrate the benign violation theory with the social information processing theory to examine the indirect effects of project leader's sense of humor on individual- and team-level creativity via team psychological safety.Design/methodology/approachThe authors collected data from 165 members nested in 45 teams working on construction projects in China. The construct's factor structure and discriminant validity were established through confirmatory factor analysis. The authors used multi-level modeling via Mplus to test team-level to the individual-level direct and indirect hypotheses, while team-level direct and indirect hypotheses were tested using ordinary least squares regression.FindingsThe results show that the leader's humor has a dual positive direct effect on individual and team creativity. Furthermore, these effects are partially mediated by team psychological safety. The implications of these findings to improve the construction management theory and practice are discussed in the manuscript.Originality/valueThe current study contributes to the literature by understanding the significance of leader humor in predicting individual-level and team-level creativity within the construction sector. It expands the literature by examining team psychological safety as the underlying mechanism in the relationship between leader humor and creativity.
Outward foreign direct investment and the economic growth of Central, East and Southeast Europe: an asymmetric approach
Authors: Kurtovic Safet , Halili Blerim , Maxhuni Nehat , Krasniqi Bujar 
Published: March 2023

PurposePrevious studies have mostly estimated there to be a symmetric effect in the Foreign direct investment (FDI) inflow regarding the economic growth of Central, East and Southeast European (CESEE) countries. However, for the CESEE countries, as well as for the majority of countries around the world, there has been no study that has estimated the symmetric and asymmetric effect of outward FDI on economic growth. The main objective of this study is to estimate whether the relation between outward FDI and economic growth in CESEE countries is symmetric or asymmetric.Design/methodology/approachThis study includes a sample based on eight CESEE countries. The authors used the linear and non-linear autoregressive distributed lag (ARDL) model and annual data for the period from 1990 to 2020.FindingsIn the long run, in the linear ARDL model, a significant symmetrical effect due to OFDI on the economic growth of Romania and Slovenia was found, while in the non-linear ARDL model, a significant asymmetric effect of OFDI on the economic growth of Bulgaria, Poland, Romania, Russia, Slovenia and Slovakia was found. In six out of the eight countries, asymmetry was found while symmetry was found in the other two. Poorer symmetry results can be ascribed to the lack of linear model neglecting the asymmetric behaviour of the positive and negative change decomposition as part of the OFDI movement, which leads to the wrong conclusion.Originality/valueThis is the first study to evaluate the asymmetric effect of outward FDI on the economic growth of eight CESEE countries.
Innovating in data-driven production environments: simulation analysis of Net-CONWIP priority rule
Authors: Diaz Rafael , Ardalan Ali 
Published: March 2023

PurposeMotivated by recent research indicating that the operational performance of an enterprise can be enhanced by building a supporting data-driven environment in which to operate, this paper presents a simulation framework that enables an examination of the effects of applying smart manufacturing principles to conventional production systems, intending to transition to digital platforms.Design/methodology/approachTo investigate the extent to which conventional production systems can be transformed into novel data-driven environments, the well-known constant work-in-process (CONWIP) production systems and considered production sequencing assignments in flowshops were studied. As a result, a novel data-driven priority heuristic, Net-CONWIP was designed and studied, based on the ability to collect real-time information about customer demand and work-in-process inventory, which was applied as part of a distributed and decentralised production sequencing analysis. Application of heuristics like the Net-CONWIP is only possible through the ability to collect and use real-time data offered by a data-driven system. A four-stage application framework to assist practitioners in applying the proposed model was created.FindingsTo assess the robustness of the Net-CONWIP heuristic under the simultaneous effects of different levels of demand, its different levels of variability and the presence of bottlenecks, the performance of Net-CONWIP with conventional CONWIP systems that use first come, first served priority rule was compared. The results show that the Net-CONWIP priority rule significantly reduced customer wait time in all cases relative to FCFS.Originality/valuePrevious research suggests there is considerable value in creating data-driven environments. This study provides a simulation framework that guides the construction of a digital transformation environment. The suggested framework facilitates the inclusion and analysis of relevant smart manufacturing principles in production systems and enables the design and testing of new heuristics that employ real-time data to improve operational performance. An approach that can guide the structuring of data-driven environments in production systems is currently lacking. This paper bridges this gap by proposing a framework to facilitate the design of digital transformation activities, explore their impact on production systems and improve their operational performance.
UGF-based signature reliability for solar panel k-out-of-n- multiplex systems
Authors: Ram Mangey , Kumar Akshay , Naaz Sadiya 
Published: March 2023

PurposeThe purpose of this paper is to evaluate the reliability and signature reliability of solar panel k-out-of-n-multiplex system with the help of universal generating function.Design/methodology/approachEnergy scarcity and global warming issues have become important concerns for humanity in recent decades. To solve these problems, various nations work for renewable energy sources (RESs), including sun, breeze, geothermal, wave, radioactive and biofuels. Solar energy is absorbed by solar panels, referred to as photovoltaic panels, which then transform it into electricity that can be used to power buildings or residences. Remote places can be supplied with electricity using these panels. Solar energy is often generated using a solar panel that is connected to an inverter for power supply. As a result, a converter reliability evaluation is frequently required. This paper presents a study on the reliability analysis of k-out-of-n systems with heterogeneous components. In this research, the universal generating function methodology is used to identify the reliability function and signature reliability of the solar array components. This method is commonly used to assess the tail signature and Barlow-Proschan index with independent and identically distributed components.FindingsThe Barlow-Proschan index, tail signature, signature, expected lifetime, expected cost and minimal signature of independent identically distributed are all computed.Originality/valueThis is the first study of solar panel k-out-of-n-multiplex systems to examine the signature reliability with the help of universal generating function techniques with various measures.
Tesla, Inc.: addressing ESG challenges
Authors: Subramanian Ram 
Published: March 2023

Research methodology
This case is based on primary archival research. The original reports from MSCI, Sustainalytics and S&P 500 formed the foundation of the case in addition to the 144-page Tesla’s 2021 Impact Report. Secondary sources were used to provide contextual information. All sources are cited as endnotes.

Case overview/synopsis
In June 2022, Tesla, Inc., the Austin, Texas-based electric car company faced a number of challenges that called into question its environmental, social and governance (ESG) credentials. Questioning the company’s corporate governance practices, SOC Capital, a watchdog organization publicly released a letter that it had sent to the United States Securities and Exchange Commission where it had demanded that the agency sanction the company for not replacing an independent director at its next stockholder meeting. The State of California’s Department of Fair Housing and Employment filed a lawsuit alleging various counts of discrimination at Tesla’s manufacturing facility in Fremont, California. S&P Global removed the company from its index of ESG companies. This action had negative consequences for the company’s stock price. Tesla’s board of directors, led by Robyn M. Denholm, had to address Tesla’s overall approach to ESG in light of these challenges.

Complexity academic level
The case is suitable for an upper-level undergraduate or an MBA course on strategy or strategic management.The issues in the case involve the stakeholder perspective, corporate governance and the purpose of a firm. Instructors face two choices here: using this case early in the course introduces the broader stakeholder perspective early on without addressing it as an afterthought at the very end of the course. The other choice is to use it at the end because most strategy textbooks cover these topics at the back end.
Attenuating pseudo S‐wave splitting caused by vector infidelity
Authors: de Souza Bezerra Moacyr , Gaiser James E. , Simmons James L. 
Published: March 2023

AbstractShear wave (S‐wave) splitting analysis can provide knowledge about, among other properties, principal stress directions and fracture orientation. It is an essential step in multi‐component, converted wave processing. Caution must be taken, however, when performing such analysis on ocean bottom cable seismic data, which is highly susceptible to different coupling of the two horizontal components with the seafloor. Receiver coupling correction methods attempt to balance the seismic response on all components and seek to minimize spurious resonance effects. We show on field data from an ocean bottom cable seismic dataset how these coupling effects that simulate S‐wave splitting behaviour can be attenuated to significantly improve PS‐wave stack images of the shallow seabed. Furthermore, corrected pre‐stack data of all azimuths may reveal true splitting effects for stress and fracture information.
Discovery of escapee tumour cells—a milestone in cancer surgery
Authors: Wong Kevin K. F. , Fung James T. K. , Yu Carmen S. W. , Cheung Jackie S. L. , Wong W. F. , Yam P. C. , Yiu C. W. , Yiu H. L. , Leung S. K. 
Published: March 2023

AbstractBackgroundComplete excision of tumour is the basic principle of curative surgery and traditionally oncological en‐bloc tumour resection is a common practice. However, ironically, it is questionable whether surgery itself will cause tumour spillage.MethodFrom January 2019 to March 2022, 133 tumour‐related operations were performed. Routine operating field toileting was performed using warm normal saline before the end of operations. A filter was connected to the suction device throughout the whole operation processes. Sediments being trapped by the filter were sent for histopathology to look for the presence of spillage tumour cells—escapee tumour (ET) cells.ResultsA total of 26 (19.5%) of the collected residue showed the presence of ET cells while 16 residue samples (12%) revealed the presence of atypical cells. Incomplete resection (R1, R2 resection; P = .005, B = 1.519), advanced N‐stage (N2 or N3 disease; P = .031, B = 1.510) and certain cancer type (oesophageal cancer in this study; P = .027, B = −1.567) are the statistically significant factors related to the presence of ET cells.ConclusionTumour spillage occurs during operations. Long‐term follow‐up and larger‐scale studies are required to determine the clinical significance of the positive ET cell cases and how to prevent tumour spillage during operations in the future.
Global governance for digital sequence information on genetic resources: Demand, progress and reforming paths
Authors: Qin Geng , Yu Hanzhi , Wu Chao 
Published: March 2023

AbstractThe cross‐border transmission of digital sequence information (DSI) on genetic resources is an emerging global governance issue, particularly since its inclusion in the post‐2020 framework of the Convention on Biological Diversity. Based on a brief review of the value of DSI and the need for global governance, this paper identifies three elemental regimes on ‘physical’ genetic resources that are in conflict: divergent principles of sovereignty claim, global multilateral sharing and intellectual property rights protection. It then traces the progress of each elemental regime on DSI and describes their ongoing conflicts. Two reform strategies for better governance are suggested: one gradual and path‐dependent and one more radical. The basis of the radical strategy is to promote labour division and cooperation among institutions of different elemental regimes within a three‐layered system of DSI values.
Primary tracheal small‐cell carcinoma detected 11 months after surgery for pulmonary large‐cell neuroendocrine carcinoma: A case report
Authors: Sugimoto Chihiro , Teranishi Shuhei , Sawazumi Tomoe , Nagaoka Satoshi , Nagayama Hirokazu , Segawa Wataru , Hiro Shuntaro , Kajita Yukihito , Maeda Chihiro , Kubo Sousuke , Seki Kenichi , Tashiro Ken , Kobayashi Nobuaki , Yamamoto Masaki , Kudo Makoto , Kaneko Takeshi 
Published: March 2023

AbstractPrimary tracheal small‐cell carcinoma is rare, and is often treated using small‐cell lung cancer guidelines given that no standard treatment has been established for it. We report a patient in whom nodules appeared in the trachea and left main bronchus 11 months after surgery for pulmonary large‐cell neuroendocrine carcinoma; a biopsy revealed small‐cell carcinoma. Given the absence of malignant lesions elsewhere in the body, the lesions were diagnosed as primary tracheal small‐cell carcinoma. Respiratory failure progressed rapidly owing to airway stenosis caused by the growing lesion, and the patient required nasal high‐flow therapy. However, the lesions shrank a few days after commencing first‐line chemotherapy, and his respiratory failure resolved. Accelerated hyperfractionated radiotherapy was administered in conjunction with the third course of chemotherapy, and the patient ultimately achieved a complete response. Although the lesions were initially suspected of being postoperative recurrence of pulmonary large‐cell neuroendocrine carcinoma, the fact that the biopsy revealed them to be primary tracheal small‐cell carcinoma indicates that intra‐airway nodules that appear after lung cancer surgery may possibly be primary tracheal tumors.
The CSR‐19 scale: A measure of corporate social responsibility actions during COVID‐19 pandemic
Authors: Eiadat Yousef 
Published: March 2023

AbstractIn this article, I developed the CSR‐19 scale to assess the perceptions company executives have of CSR actions during the COVID‐19 pandemic and to conceptualize the economic, legal, social, and environmental aspects of CSR actions as a high‐order construct. This paper's findings suggest that the legal, environmental, and social aspects of CSR actions are being perceived to positively contribute to companies' CSR actions, but the economic aspect of CSR actions is deemed to contribute negatively to companies' CSR actions. The 16‐item CSR‐19 scale shows strong evidence of reliability as well as content, convergent, and discriminant validity in a sample of 211 Jordanian companies. Managerial implications and suggestions for applying the CSR‐19 scale in future research are presented.