bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pan-Canadian survey on the impact of the COVID-19 pandemic on cervical cancer screening and management: cross-sectional survey of healthcare professionals
Authors: El-Zein Mariam , Ali Rami , Farah Eliya , Botting-Provost Sarah , Franco Eduardo L ,   Survey Study Group
Published: June 2023

Background:The coronavirus disease 2019 (COVID-19) pandemic has caused disruptions to cancer care by delaying diagnoses and treatment, presenting challenges and uncertainties for both patients and physicians. We conducted a nationwide online survey to investigate the effects of the pandemic and capture modifications, prompted by pandemic-related control measures, on cervical cancer screening-related activities from mid-March to mid-August 2020, across Canada.Methods:The survey consisted of 61 questions related to the continuum of care in cervical cancer screening and treatment: appointment scheduling, tests, colposcopy, follow-up, treatment of pre-cancerous lesions/cancer, and telemedicine. We piloted the survey with 21 Canadian experts in cervical cancer prevention and care. We partnered with the Society of Canadian Colposcopists, Society of Gynecologic Oncology of Canada, Canadian Association of Pathologists, and Society of Obstetricians and Gynecologists of Canada, which distributed the survey to their members via email. We reached out to family physicians and nurse practitioners via MDBriefCase. The survey was also posted on McGill Channels (Department of Family Medicine News and Events) and social media platforms. The data were analyzed descriptively.Results:Unique responses were collected from 510 participants (November 16, 2020, to February 28, 2021), representing 418 fully and 92 partially completed surveys. Responses were from Ontario (41.0%), British Columbia (21.0%), and Alberta (12.8%), and mostly comprised family physicians/general practitioners (43.7%), and gynecologist/obstetrician professionals (21.6%). Cancelled screening appointments were mainly reported by family physicians/general practitioners (28.3%), followed by gynecologist/obstetrician professionals (19.8%), and primarily occurred in private clinics (30.5%). Decreases in the number of screening Pap tests and colposcopy procedures were consistently observed across Canadian provinces. About 90% reported that their practice/institution adopted telemedicine to communicate with patients.Conclusions:The area most severely impacted by the pandemic was appointment scheduling, with an important level of cancellations reported. Survey results may inform resumptions of various fronts in cervical cancer screening and management.Funding:The present work was supported by the Canadian Institutes of Health Research (operating grant COVID-19 May 2020 Rapid Research Funding Opportunity VR5-172666 Rapid Research competition and foundation grant 143347 to Eduardo L Franco). Eliya Farah and Rami Ali each received an MSc stipend from the Department of Oncology, McGill University.
Responsabilidad precontractual en la contratación administrativa a partir del principio de la confianza legítima. El caso peruano
Authors: Cuba Meneses Erick 
Published: June 2023

El desarrollo de la responsabilidad precontractual en el Perú es pobre, si es que se busca un régimen o una norma expresa en el ordenamiento. Por esta razón, la doctrina ha dedicado esfuerzos hermenéuticos para construir un sistema que permita prevenir, castigar y reparar el daño al incumplimiento de deberes precontractuales. En el derecho común, este tipo de responsabilidad pivota sobre el principio de buena fe reconocido en el régimen del acto jurídico, así como en la teoría general del contrato del Código Civil. Sin embargo, no sucede lo mismo en la regulación de los contratos estatales. La Ley No 30225, Ley de Contratos del Estado peruana, guarda silencio respecto de las formas de responsabilidad que pudieran surgir en la preparación, celebración, ejecución y terminación de un contrato. En ese sentido, el autor procura asentar las bases para construir interpretativamente un sistema de responsabilidad precontractual en el contexto de los contratos del Estado a partir del principio de la confianza legítima.
Financial Ratios and Corporate Governance's Impact on Financial Performance in the Indonesian Stock Market: The Case in Manufacturing Industry
Authors: Rahmawati Ika Yustina , Najmudin  , Adawiyah Wiwiek Robiatul , Jayanti Esih , Berniz Yulis Maulida , Utami Yuni 
Published: June 2023

Aims: Here to determine how financial ratios in this case, liquidity and leverage ratios along with an examination of corporate governance in this case, institutional and management ownership affect the company's financial performance.
Study Design: The population of the study consists of 194 manufacturing-related companies listed on the Indonesia Stock Exchange (IDX) for the 2019–2021 period. The data for this study came from the company's annual report.
Methodology: The method used to gather the data was purposeful sampling. For this inquiry, 36 businesses served as samples. The conventional assumption test, multiple regression analysis, model fit test, and hypothesis testing are tested using the analytical tool Eviews 12.
Results: Given that managerial ownership, institutional ownership, and liquidity ratios are the variables affecting the company's financial performance, the analysis' findings show that only one hypothesis—the impact of the leverage ratio on the company's financial performance—is supported, whereas H2, H3, and H4 are not.
Agro-morphological Characterization of Proso millet Germplasm for Utilization
Authors: Elangovan M. , Singode Avinash , Venkatesh Karnam , Amasiddha B. , Karthik A. Sai , Pandey Sushil , Pandey Chithra Devi 
Published: June 2023

Aims: In this study, 634 accessions of proso millet were evaluated to assess phenotypic diversity using morpho-agronomic traits, aiming to identify specific donors for desired traits.
Study Design: Augmented design.
Place and Duration of Study: During the Kharif season of 2021, a total of 634 proso millet germplasm accessions were characterized, alongside three control varieties, as part of the Institute Project (IIMR/CI/2021-2026/150) at ICAR-IIMR in Hyderabad.
Methodology: The experimental design employed was an augmented block design, and four check varieties, namely GPUP 8, TNAU 145, TNAU 164, and TNAU 202, were included.
Results: The results revealed significant variation across all the traits studied. The Principal Component Analysis (PCA) demonstrated that the first three principal components accounted for 60% of the total variation. PC1 accounted for 27.3% of the variation, followed by PC2 (22.6%) and PC3 (10%). PC1 was primarily influenced by Leaf blade length (cm), Peduncle length (cm), Panicle length (cm), Plant height (cm), and grain yield (g plant-1). Furthermore, the study identified 21 accessions with superior performance in multiple traits (3-6 traits).
Conclusion: These accessions can serve as valuable genetic resources for improving yield and quality traits. The selected multi-trait donors can be directly released for cultivation, serving as a short-term breeding goal. This approach has the potential to enable farmers to achieve high remuneration by harvesting increased yields.
Utilization of PM Street Vendor's AtmaNirbhar Nidhi (PMSVANidhi) and Pradhan Mantri Jeevan Jyoti Bima Yojana (PMJJBY) by the Urban Informal Sector
Authors: Balamurugan J. , Johns Gloria Mary , Das Priyamvada , Basu Prithvijit 
Published: June 2023

Introduction: PMSVAnidhi and PM Jeevan Jyoti Bima Yojana are two schemes which were designed to help improve the quality of the lives of the people working in urban informal sectors. The COVID-19 has had a huge impact on everyone’s daily life including the urban informal sector employees, but these schemes when found to have been implemented in a disastrous situation like this, was found to be rather disadvantageous due to some loopholes and lacunae in the designing of the scheme, rendering them useless to its beneficiaries.
Objectives: This study will evaluate the government-aided programs created to help people in the urban informal sector during the COVID-19 pandemic, and see how well they've been beneficial to the people. It was also intended to find further slits in the designs and its implementation by the authorities, other than already the existing ones.
Methodology: This study was conducted mainly through secondary literature sources such as review and research paper, electronic journals, etc.
Findings: In case of PMSVAnidhi, it was found that due to inadequate information on registration forms or a lack of knowledge, registration declined in several states, and public sector banks dispersed maximum loans, with private sector, rural, and cooperative banks contributing the most meager figures. At the same time due to people not obtaining claims and people receiving low rates, PMJJBY enrollments decreased every year. Thus, this study has shown that these schemes aren’t always fool-proof and these loopholes tend to be misused and deleterious in unfavorable times where these schemes can really help its beneficiaries.
Chemotherapy-Induced Pseudocellulitis Without Prior Radiation Exposure
Authors: Kovacs Leah D. , O’Donoghue Michaela , Cogen Anna L. 
Published: June 2023

ImportanceChemotherapy-induced pseudocellulitis is an ill-defined term for a poorly understood phenomenon. Encompassing a myriad of cellulitis-mimicking oncologic adverse cutaneous drug reactions (ACDRs), pseudocellulitis may be difficult to diagnosis, and the lack of treatment guidance may mean unnecessary antibiotic exposure and interruptions to oncologic care.ObjectivesTo use case reports to characterize the various cellulitis-mimicking reactions caused by chemotherapeutic medications, to understand how these reactions affect patient care (ie, antibiotic exposure and interruptions to oncologic treatment), and to make recommendations for improved diagnosis and care of patients with chemotherapy-induced pseudocellulitis.Evidence ReviewA systematic review of case reports of patients with pseudocellulitis was performed. Reports were identified through database searches using PubMed and Embase, with subsequent reference searches. Included publications described at least 1 case of chemotherapy-induced ACDR and used the term pseudocellulitis or showed evidence of cellulitis mimicry. Cases of radiation recall dermatitis were excluded. Data were extracted from a total of 32 publications representing 81 patients diagnosed with pseudocellulitis.FindingsOf the 81 cases (median [range] age, 67 [36-80] years; 44 [54%] male patients), most were associated with gemcitabine use; pemetrexed use was reported less frequently. Only 39 were considered to be true chemotherapy-induced pseudocellulitis. These cases resembled infectious cellulitis and did not meet diagnostic criteria for any known diagnoses; therefore, these were described solely as pseudocellulitis. Of this group, 26 patients (67%) had been administered antibiotics before the correct diagnosis was made, and 14 patients (36%) experienced interruptions to their oncologic treatment plans.Conclusions and RelevanceThis systematic review found a variety of chemotherapy-induced ACDRs that mimic infectious cellulitis, including a group of reactions termed pseudocellulitis that do not meet criteria for other diagnoses. A more universally accepted definition and clinical research on chemotherapy-induced pseudocellulitis would allow for more accurate diagnosis, effective treatment, antibiotic stewardship, and continuation of oncologic treatment.
Characterization of Brain Volume Changes in Aging Individuals With Normal Cognition Using Serial Magnetic Resonance Imaging
Authors: Fujita Shohei , Mori Susumu , Onda Kengo , Hanaoka Shouhei , Nomura Yukihiro , Nakao Takahiro , Yoshikawa Takeharu , Takao Hidemasa , Hayashi Naoto , Abe Osamu 
Published: June 2023

ImportanceCharacterizing longitudinal patterns of regional brain volume changes in a population with normal cognition at the individual level could improve understanding of the brain aging process and may aid in the prevention of age-related neurodegenerative diseases.ObjectiveTo investigate age-related trajectories of the volumes and volume change rates of brain structures in participants without dementia.Design, Setting, and ParticipantsThis cohort study was conducted from November 1, 2006, to April 30, 2021, at a single academic health-checkup center among 653 individuals who participated in a health screening program with more than 10 years of serial visits.ExposureSerial magnetic resonance imaging, Mini-Mental State Examination, health checkup.Main Outcomes and MeasuresVolumes and volume change rates across brain tissue types and regions.ResultsThe study sample included 653 healthy control individuals (mean [SD] age at baseline, 55.1 [9.3] years; median age, 55 years [IQR, 47-62 years]; 447 men [69%]), who were followed up annually for up to 15 years (mean [SD], 11.5 [1.8] years; mean [SD] number of scans, 12.1 [1.9]; total visits, 7915). Each brain structure showed characteristic age-dependent volume and atrophy change rates. In particular, the cortical gray matter showed a consistent pattern of volume loss in each brain lobe with aging. The white matter showed an age-related decrease in volume and an accelerated atrophy rate (regression coefficient, −0.016 [95% CI, −0.012 to –0.011]; P &amp;lt; .001). An accelerated age-related volume increase in the cerebrospinal fluid–filled spaces, particularly in the inferior lateral ventricle and the Sylvian fissure, was also observed (ventricle regression coefficient, 0.042 [95% CI, 0.037-0.047]; P &amp;lt; .001; sulcus regression coefficient, 0.021 [95% CI, 0.018-0.023]; P &amp;lt; .001). The temporal lobe atrophy rate accelerated from approximately 70 years of age, preceded by acceleration of atrophy in the hippocampus and amygdala.Conclusions and RelevanceIn this cohort study of adults without dementia, age-dependent brain structure volumes and volume change rates in various brain structures were characterized using serial magnetic resonance imaging scans. These findings clarified the normal distributions in the aging brain, which are essential for understanding the process of age-related neurodegenerative diseases.
Leaf‐Structure‐Inspired Through‐Hole Electrode with Boosted Mass Transfer and Photothermal Effect for Oxygen Evolution Reactions
Authors: Zhou Yaya , Ma Yibing , Wang Xinyu , Yang Guiyan , Ding Yiqin , Cui Yushuang , Zhang Jian , Ge Haixiong , Sun Junting 
Published: June 2023

AbstractThe sluggish kinetics of oxygen evolution reaction (OER) remains a bottleneck for the electrocatalytic water splitting. In addition to improving the intrinsic activity of electrocatalysts, the electrode structure and external environment also have a significant influence on catalytic performance. Inspired by photosynthesis in plant leaves, a photothermal conversion strategy is proposed via the decoration of photothermal responsive MoS2/FeCoNiS‐nanotube (MoS2/FeCoNiS‐NT) on designed through‐hole porous nickel foam (PNF), defined as MoS2/FeCoNiS‐NT@PNF, to boost OER performance. The PNF facilitated bubble transport in OER by mimicking stomata structure of the leaf, and simultaneously, the MoS2/FeCoNiS‐NT increases light absorption and photothermal conversion by simulating the leaf epidermis. Benefiting from bionic structure and functional design, the MoS2/FeCoNiS‐NT@PNF electrode exhibits highly effective oxygen‐evolving ability and excellent photothermal conversion capacity (surface temperature: 25 °C → 52.3 °C, AM1.5G), which increases the intrinsic activity of electrocatalysts. With the assistance of optimized electrode structure and the photothermal effect, the MoS2/FeCoNiS‐NT@PNF electrode exhibits a low overpotential of 214 mV to achieve 50 mA cm−2. This research reveals that tuning the electrode structure can promote light absorption in the electrolyte in favor of OER performance, which can serve as an inspiration for the development of high‐performance catalytic electrodes.
Convergence of Calcium Channel Regulation and Mechanotransduction in Skeletal Regenerative Biomaterial Design
Authors: LaGuardia Jonnby S. , Shariati Kaavian , Bedar Meiwand , Ren Xiaoyan , Moghadam Shahrzad , Huang Kelly X. , Chen Wei , Kang Youngnam , Yamaguchi Dean T. , Lee Justine C. 
Published: June 2023

AbstractCells are known to perceive their microenvironment through extracellular and intracellular mechanical signals. Upon sensing mechanical stimuli, cells can initiate various downstream signaling pathways that are vital to regulating proliferation, growth, and homeostasis. One such physiologic activity modulated by mechanical stimuli is osteogenic differentiation. The process of osteogenic mechanotransduction is regulated by numerous calcium ion channels—including channels coupled to cilia, mechanosensitive and voltage‐sensitive channels, and channels associated with the endoplasmic reticulum. Evidence suggests these channels are implicated in osteogenic pathways such as the YAP/TAZ and canonical Wnt pathways. This review aims to describe the involvement of calcium channels in regulating osteogenic differentiation in response to mechanical loading and characterize the fashion in which those channels directly or indirectly mediate this process. The mechanotransduction pathway is a promising target for the development of regenerative materials for clinical applications due to its independence from exogenous growth factor supplementation. As such, also described are examples of osteogenic biomaterial strategies that involve the discussed calcium ion channels, calcium‐dependent cellular structures, or calcium ion‐regulating cellular features. Understanding the distinct ways calcium channels and signaling regulate these processes may uncover potential targets for advancing biomaterials with regenerative osteogenic capabilities.
Programming Cell‐Derived Vesicles with Enhanced Immunomodulatory Properties
Authors: Neupane Khaga R. , Ramon Geraldine S. , Harvey Brock , Chun Byeong , Aryal Surya P. , Masud Abdullah A. , McCorkle J. Robert , Kolesar Jill M. , Kekenes‐Huskey Peter M. , Richards Christopher I. 
Published: June 2023

AbstractTumor‐associated macrophages are the predominant immune cells present in the tumor microenvironment and mostly exhibit a pro‐tumoral M2‐like phenotype. However, macrophage biology is reversible allowing them to acquire an anti‐tumoral M1‐like phenotype in response to external stimuli. A potential therapeutic strategy for treating cancer may be achieved by modulating macrophages from an M2 to an M1‐like phenotype with the tumor microenvironment. Here, programmed nanovesicles are generated as an immunomodulatory therapeutic platform with the capability to re‐polarize M2 macrophages toward a proinflammatory phenotype. Programmed nanovesicles are engineered from cellular membranes to have specific immunomodulatory properties including the capability to bidirectionally modulate immune cell polarization. These programmed nanovesicles decorated with specific membrane‐bound ligands can be targeted toward specific cell types including immune cells. Macrophage‐derived vesicles are engineered to enhance immune cell reprogramming toward a proinflammatory phenotype.
Eye‐Mimicked Neural Network Composed of Photosensitive Neural Spheroids with Human Opsin Proteins
Authors: Park Byeongho , Bang Seokyoung , Hwang Kyeong Seob , Cha Yeon Kyung , Kwak Jisung , Tran Na Ly , Kim Hyo‐Suk , Park Subeen , Oh Seung Ja , Im Maesoon , Chung Sooyoung , Kim Jongbaeg , Park Tai Hyun , Song Hyun Seok , Kim Hong Nam , Kim Jae Hun 
Published: June 2023

AbstractAn in vitro model, composed of the short‐wavelength human opsins and rhodopsins, is created. Two types of photosensitive neural spheroids are transfected for selective reaction under bluish‐purple and green lights. These are employed to two devices with intact neuron and neural‐spheroid to study the interaction. By photostimulation, the photosensitive spheroid initiated photoactivation, and the signal generated from its body is transmitted to adjacent neural networks. Specifically, the signal traveled through the axon bundle in narrow gap from photosensitive spheroid to intact spheroid as an eye‐to‐brain model including optic nerve. The whole process with photosensitive spheroid is monitored by calcium ion detecting fluorescence images. The results of this study can be applied to examine vision restoration and novel photosensitive biological systems with spectral sensitivity.
Quasi‐Localized High‐Concentration Electrolytes for High‐Voltage Lithium Metal Batteries
Authors: Cai Wenlong , Deng Yan , Deng Zhiwen , Jia Ye , Li Zeheng , Zhang Xuemei , Xu Changhaoyue , Zhang Xue‐Qiang , Zhang Yun , Zhang Qiang 
Published: June 2023

The poor compatibility with Li metal and electrolyte oxidation stability preclude the utilization of commercial ester‐based electrolytes for high‐voltage lithium metal batteries. This work proposes a quasi‐localized high‐concentration electrolyte (q‐LHCE) by partially replacing solvents in conventional LiPF6 based carbonated electrolyte with fluorinated analogs (fluoroethylene carbonate (FEC), 2,2,2‐trifluoroethyl methyl carbonate (FEMC)) with weakly‐solvating ability. The q‐LHCE enables the formation of an anion‐rich solvation sheath, which functions like LHCE but differs in the partial participation of weakly‐solvating cosolvent in the solvation structure. With this optimized electrolyte, inorganic‐dominated solid electrolyte interphases are achieved on both the cathode and anode, leading to uniform Li deposition, suppressed electrolyte decomposition and cathode deterioration. Consequently, q‐LHCE supports stable cycling of Li | LiCoO2 (≈3.5 mAh cm−2) cells at 4.5 V under the whole climate range (from −20 to 45 °C) with limited Li consumption. A practical ampere‐hour level graphite | LiCoO2 pouch cell at 4.5 V and aggressive Li | LiNi0.5Mn1.5O4 cell at 5.0 V with excellent capacity retention further reveals the effectiveness of q‐LHCE. The refinement of old‐fashioned carbonate electrolytes provides new perspectives toward practical high‐voltage battery systems.
Principles of Designing Electrocatalyst to Boost Reactivity for Seawater Splitting
Authors: Liu Xiaobin , Chi Jingqi , Mao Huimin , Wang Lei 
Published: June 2023

AbstractDirectly seawater electrolysis would be a transformative technology for large‐scale carbon‐neutral hydrogenproduction without relying on pure water. However, current seawater splitting is challenged by detrimental chlorine chemistry, the sluggish kinetics, and the existence of impurities/precipitates, making it more difficult than pure water splitting. So far, tremendous efforts have been made to develop electrocatalysts to boost the electrocatalytic hydrogen evolution reaction (HER) and oxygen evolution reaction (OER) activities for seawater‐based electrolyzers. To get further insights into the current achievements and future perspectives of the catalysts for seawater electrolysis, general principles are summarized for a comprehensive optimization, ranging from active sites, electrochemical interface, to electron transfer path, to fully improve electrocatalytic performance for seawater electrolysis. Then, aiming at the different challenges of the cathode and anode for seawater electrolysis, unique strategies to design effective cathodic and anodic catalysts, such pH design criterion, selective HER/OER, and Cl− blocking layers, are discussed, respectively. Also, several future fields which are worthy for further exploration as rational extensions of developing electrocatalysts toward practical applications are put forward.