bluuebunny/crossref_metadata_2025_split huggingface dataset:
Differences in clinical significance of bronchodilator responses measured by forced expiratory volume in 1 second and forced vital capacity
Authors: Choi Joon Young , Kim Sung Kyoung , Lee Jin Hwa , Jung Ki-Suck , Yoo Kwang Ha , Hwang Ki-Eun , Lee Jong Deog , Kim Yu-Il , Yoon Hyoung Kyu , Um Soo-Jung 
Published: February 2023

Background
The clinical implication of bronchodilator response (BDR) is not fully understood. However, BDR is frequently present in patients with chronic obstructive pulmonary disease (COPD). We identified the differences in clinical features regarding BDR. In addition, we divided BDR into BDR for forced expiratory volume in 1 s (FEV1) and BDR for forced vital capacity (FVC; i.e., BDR-FEV1 and BDR-FVC, respectively) and analyzed clinical significance.

Methods
We used data from the Korea COPD Subgroup Study, a multicenter cohort study of COPD patients recruited from 54 centers in South Korea since April 2012. We analyzed differences in baseline characteristics, 1-year exacerbation rate, and 3-year FEV1 decline between BDR negative and positive patients. Moreover, we analyzed the differences in clinical features between BDR-FEV1 positive and negative patients and between BDR-FVC positive and negative patients.

Results
Of the 2,181 patients enrolled in this study, 366 (16.8%) were BDR positive. BDR positive patients were more likely to be ever-smokers and to have a lower body mass index and higher symptom scores compared to BDR negative patients. Baseline FEV1 and FEV1/FVC were lower in the BDR positive compared to the BDR negative group (1.7 ± 0.6 and 1.6 ± 0.5, respectively, p < 0.01; 50.9 ± 12.1 and 46.5 ± 14.8, respectively, p < 0.01). BDR positive patients were more likely to have been diagnosed with asthma–COPD overlap and to receive inhaled corticosteroids (ICS) than BDR negative patients. BDR-FVC patients were more likely to be smokers, suffer from worse symptoms and have lower lung function than those with no BDR-FVC. BDR had no significant effect on 1-year moderate to severe or severe exacerbation rates or 3-year annual FEV1 decline. Interactive effects of ICS and BDR on the exacerbation rate were not significant in any group.

Conclusions
In this study, BDR positive patients were more likely to be ever-smokers and to have worse symptoms and lung function than BDR negative patients. BDR-FVC was associated with worse symptom control and lung function compared to BDR-FEV1. However, there were no significant differences in exacerbation rate or decline in lung function in any BDR group. In addition, the effects of ICS on exacerbations were not significant in any group.
Stigma, Tolerance, and Acceptance in the Lives of Sexual and Gender Minority Nebraskans
Authors: Holt Natalie R. , Price Sarah , Mocarski Richard , Obasi Sharon , Huit Terrence Z. , Weekley Tiff , Hall Margeret , Rajaram Shireen S. , Hope Debra A. 
Published: February 2023

Abstract
Experiences of stigma and acceptance profoundly affect the lives of sexual and gender minority (SGM) individuals and are often dependent on context, such as geographic location. Through interviews with twenty sexual and gender minority individuals living in Nebraska, this study aimed to explore participants’ experiences of rejection and acceptance in different spheres to better understand how stigma operates. Thematic analysis revealed primary themes of Stigma and Discrimination and Signs of Support. However, reports of stigma and acceptance were often complex and intertwined. For example, participants described that receiving support from others categorized as merely “tolerant” is positive, given their expectations of rejection when living in a politically conservative state. These findings offer a contextualized understanding of how stigma and support affect SGM individuals at individual, interpersonal, community, and political levels in an underserved state.
Here, Queer, and Paranoid! On Acrid Sociality and Collaborating Otherwise
Authors: Conrad Ryan , Pelletier Gary Lee 
Published: February 2023

Abstract
The work required of politicized subjects to act together, across difference towards transformative justice, is inexhaustible, complex, and difficult. Sometimes it is a battle to speak to one's peers, let alone act in concert with them. This article addresses destructive tendencies of intracommunal queer relationality in particular. Recent events within queer networks have helped us to understand particular impasses in queer organizing as acerbic and self-destructive—what we term here as “acrid.” In such instances, although some useful spaces for critique, criticism, praise, questions, wonderings, rants, reflections, and connections opened up, battlefields on which allied community members viciously attacked one another also manifested. Although generative at times, the debates and dialogues contained a great deal of vitriol, judgment, complacency, demands for apologies and annihilation, and in some instances, threatening and violent language, all which inhibit the momentum of our movements. This article is neither a content analysis of these myriad breakdowns in queer collaboration, nor are we interested in proving that such examples of destructive paradoxical relationality indeed happen. They happen. Instead, we assess the damage of devastated intracommunal relations, consider their queer propensities, and creatively theorize alternative possibilities for better collaborations throughout our queer spaces, communities, and futures.
Problematika Globalisasi Hukum di Indonesia: Dari Perjanjian Internasional Menjadi Hukum Nasional
Authors: Fadli Zul 
Published: February 2023

In our time, globalization can not be avoided, technology and economic are themain factors. Because people become more and more connected, the globalization of lawis imminent. Through interntional egreement, the globalization of law find its power to be enforced. Nevertheless, this sircumstances alsocreated new challenges, especially on legal aspect. Legal transplantation can not be easily pursued because the characteristic of legal systemof every nation is varied.
Dilematika Sengketa Pertanahan dan Penyelesaiannya dalam Perspektif Hukum Positif
Authors: Iswantoro Iswantoro 
Published: February 2023

Problems of land disputes issues from time to time increased both the qualityand quantity. The reason is because the needs of an increasingly complex use of land,while land availability is very limited. Besides, the cause can be triggered by the government regulations that make legislation happen to overlap and disharmony in the implementation. This problem coupled with a lack of understanding of the law in society as a result of acts committed against the land he owned, and the publication of the registration system which adopts negative publicity, making the lawsuit and opening faucets to objections from other parties on the ground that have been registered. The inequality in land ownership, and the rights of dual certificates and land use that doesnot comply with the permit location, allocation, use, and make use of the land into the complex problems of land disputes.It is also encouraged in the historical experience of our long agrarian law as aresult of government policy that has a tendency that the land be used for a political commodity. It should be understood as well the condition of land administration in times past were less orderly also be a driving force of land disputes. With this condition need to be made as a container seeking justice, legal protection and law enforcement, namely the judiciary for its container. Besides settling land disputes can malalui administrative channels that BPN, and Mediation, Reconciliation and ADR, which greatly contributed to the completion of their work land disputes. Therefore necessary stakeholders so that these ideals can be realized.
Music and Grammar
Authors: Scartoni Paolo 
Published: February 2023

Dante’s original and insightful linguistics and poetics have prompted important conversations among scholars, in terms of their anthropological, theological, and philosophical implications. In this article, I reconsider Dante’s understanding of language and poetics from the perspective of grammar and music. I bring together the scholarship from these two disciplines to analyze Dante’s theoretical and poetical works, and I argue that grammar and music offered Dante two distinct ways to think about language. I trace the relationship between the two disciplines in the De Vulgari Eloquentia first, and in the first cantos of the Comedy (Inf. 1–3), in the second part of this article. Ultimately, I show that a deeper understanding of Dante’s grammatical and musical models of linguistic inquiry can shed new light on our comprehension not only of his poetics but also of his ethical and political project.
A new method for writer identification based on historical documents
Authors: Gattal Abdeljalil , Djeddi Chawki , Abbas Faycel , Siddiqi Imran , Bouderah Brahim 
Published: February 2023

Abstract
Identifying the writer of a handwritten document has remained an interesting pattern classification problem for document examiners, forensic experts, and paleographers. While mature identification systems have been developed for handwriting in contemporary documents, the problem remains challenging from the viewpoint of historical manuscripts. Design and development of expert systems that can identify the writer of a questioned manuscript or retrieve samples belonging to a given writer can greatly help the paleographers in their practices. In this context, the current study exploits the textural information in handwriting to characterize writer from historical documents. More specifically, we employ oBIF(oriented Basic Image Features) and hinge features and introduce a novel moment-based matching method to compare the feature vectors extracted from writing samples. Classification is based on minimization of a similarity criterion using the proposed moment distance. A comprehensive series of experiments using the International Conference on Document Analysis and Recognition 2017 historical writer identification dataset reported promising results and validated the ideas put forward in this study.
UBE2J1 knockdown promotes cell apoptosis in endometrial cancer via regulating PI3K/AKT and MDM2/p53 signaling
Authors: Zhang Ping , Guo Huiping , Zhao Fang , Jia Ke , Yang Fei , Liu Xiaoli 
Published: February 2023

Abstract
Emerging evidence has demonstrated that ubiquitin conjugating enzyme E2 J1 (UBE2J1) exerts pivotal function in many cancers. UBE2J1 was reported to be dysregulated in endometrial cancer (EC). This study was designed to further investigate the regulatory character and mechanism of UBE2J1 in EC. Bioinformatic tools and databases were used to analyze gene expression pattern and gene expression correlation in EC tissues, and the prognosis of EC patients. Gene expression was evaluated by reverse-transcription quantitative polymerase chain reaction. Western blot was used for protein level detection. In vitro cell apoptosis was detected by flow cytometry analyses and TUNEL assays. In vivo cell apoptosis was evaluated by detecting Bax and Bcl-2 expression in tumor tissues via immunohistochemical and western blot analyses. In this study, UBE2J1 knockdown promoted cell apoptosis in EC cells and in mouse models of EC. PI3K and AKT expression is positively correlated with UBE2J1 level and is related to poor prognosis of EC patients. UBE2J1 knockdown repressed the PI3K/AKT pathway both in vitro and in vivo. UBE2J1 downregulation decreased MDM2 expression, but increased p53 expression. MDM2 overexpression reverses the promotion of UBE2J1 knockdown on cell apoptosis in EC. Overall, UBE2J1 knockdown induces cell apoptosis in EC by inactivating the PI3K/AKT signaling and suppressing the MDM2/p53 signaling.
Delivery in a vertical birth chair supported by freedom of movement during labor: A randomized control trial
Authors: Hacıvelioğlu Dilek , Tavşanlı Nurgül Güngör , Şenyuva İrem , Kosova Funda 
Published: February 2023

Abstract
To evaluate the effect of delivery in a vertical birth chair (VBC) and traditional delivery table (DT) supported by women’s movement during labor on the labor process, fetal outcome, maternal hormone levels, birth comfort, and satisfaction. This randomized controlled trial was conducted with 1:1:1 allocation. Group 1: in the VBC in upright position, Group 2: on the DT in supine position, these groups supported by freedom of movement, control group: on the DT in supine position, labor in bed. The duration of second stage of labor was not different between the groups (p = 0.246). The occurrence of instrumental birth, episiotomy, and perineal laceration was also not different among the groups (p = 0.772, p = 0.953, and p = 0.124). The use of uterotonic was observed in control group (p = 0.001). 1 and 5 APGAR scores of newborns were not different in all groups (p = 0.121, p = 0.268). The lowest pain score was observed in Group 1 (p = 0.001). Birth comfort and satisfaction were higher in Group 1 (p = 0.001 and p = 0.001). Decreased postpartum prolactin levels and increased postpartum oxytocin levels were observed in the control and Group 1 (p = 0.004, p = 0.006). Freedom of movement during labor and delivery using VBC in upright position can play birth-promoting and supporting role. There were no negative effects on the fetal outcome.
High mechanical performance of 3-aminopropyl triethoxy silane/epoxy cured in a sandwich construction of 3D carbon felts foam and woven basalt fibers
Authors: Taieh Nabil Kadhim , Khudhur Salman Khayoon , Fahad Eman Abd Alhadi , Zhou Zuowan , Hui David 
Published: February 2023

Abstract
Epoxy-based sandwich composites with improved economic efficiency were developed to better utilize composite components with functions such as high mechanical performance and light weight, which influenced quality for load-bearing applications. Herein, an epoxy-based sandwich composite was made by laminating woven basalt fibers (WBFs) as a face sheet on 3D carbon felt foam (3D CFs) as a core material. The cast-in-place process was used to infuse the epoxy solution within the sandwich, resulting in bicontinuous composites with outstanding mechanical characteristics and high performance. In addition, the epoxy solution was combined with a silane coupling agent to boost the composite’s toughness by enhancing the adhesion between the fibers and the epoxy. The mechanical properties of epoxy composites were also found to be much improved when WBFs were used as a face on 3D CF foam. Compared to the epoxy/3DCFs/WBFs composite sandwich to pure epoxy, the flexural and tensile strengths improved by 298.1 and 353.8%, respectively, while the impact strength rose to 135 kJ/m2. This research shows a new way to make a new process for making sandwich composites with epoxy that is cheap and strong.
Modern analytical approach in biopolymer characterization
Authors: Priya Gunasekaran , Shanthi Natarajan , Pavithra Sundaramoorthy , Sangeetha Soundararajan , Murugesan Subbiah , Shyamalagowri Shanmugasundaram 
Published: February 2023

Abstract
Biopolymers have received a lot of interest recently, and academic and industrial research on biopolymers has been refocused. These biopolymers comprise naturally occurring substances as well as artificial substances created from naturally occurring monomers. Plastics have the potential to be replaced by biopolymers because they are hazardous to the environment and rely on nonrenewable resources like petroleum for production. Due to the overwhelming interest in biopolymers, characterization tools and processes have emerged as crucial components in biopolymer research to examine and enhance the characteristics and functionality of materials based on biopolymers. When evaluating the performance of these bio-nanocomposites, using the right tools for characterization is crucial. This review concentrated on high-level analytical methods for characterizing biopolymers, biopolymer-based composites, and their derivatives structurally, physically, and chemically. The most common analytical instrument methods based on microscopy (Optical, laser scanning confocal, scanning tunneling, scanning probe, differential dynamic, scanning, and transmission electron) and spectroscopy (Fourier transform infrared, X-ray diffraction, and Raman). The use of these tools for characterization in current research studies is also highlighted in order to demonstrate how the biopolymer under study might be used in various applications.
Tod und Trauer – eine ganzheitliche Perspektive
Authors: Kemper Claudia 
Published: February 2023

Zusammenfassung
Der Tod ist eine Verlusterfahrung und für Sterbende, deren Nahestehenden aber auch für versorgende Personen der Gesundheitsfachberufe mit schmerzhaften Gefühlen der Trauer verbunden. Je nach Art und Umständen des Todes kann Trauer auch pathogene Risiken entfalten und sich eine anhaltende Trauerstörung entwickeln. Zur Vermeidung dieser Risiken sind ganzheitliche Unterstützung mit dem Ziel der Förderung von Resilienz und Coping-Strategien notwendig.
Ethik der Sorge am Lebensende
Authors: Maio Giovanni 
Published: February 2023

Zusammenfassung
Nirgendwo wird die Notwendigkeit einer Ethik der Sorge so deutlich, wie im Umgang mit dem sterbenden Menschen, denn die Ethik der Sorge ist von ihrem Selbstverständnis genau die Antwort, die wir dem Menschen am Lebensende schulden. Im Beitrag wird herausgearbeitet, worin die Wesensmerkmale der Sorge bestehen und wodurch sich die Sorge von der bloßen Verrichtung unterscheidet.
Der KV-Leichenschaudienst in Berlin, 2021/2022
Authors: Bardehle Doris , Larscheid Patrick 
Published: February 2023

Zusammenfassung
Die Leichenschau wird durch das Berliner Bestattungsgesetz geregelt. Unter Leitung der Kassenärztlichen Vereinigung (KV) Berlin gibt es einen Leichenschaudienst (LSD) rund um die Uhr für Anforderungen zur Leichenschau durch die Bevölkerung, Pflegeeinrichtungen und die Polizei. Den KV-LSD gibt es nur in einigen Bundesländern, deshalb berichten wir über die Berliner Erfahrungen der Jahre 2021/2022. Im Jahr 2021 wurden in Berlin 39.517 Leichenschauen durchgeführt. Bei 30% aller Verstorbenen erfolgte die Leichenschau durch den Leichenschaudienst der KV.
Restrukturierungswidrige Beschlüsse
Authors: Skauradszun Dominik , Harnack Alana Julia 
Published: February 2023

Abstract

71Der Beitrag lotet anhand von Beispielsfällen aus, welche gesellschaftsrechtlichen Beschlüsse der Anteilsinhaber in der Restrukturierung eines Unternehmens, mit denen Einfluss auf die Restrukturierung genommen werden soll, rechtmäßig und welche restrukturierungswidrig sind. Aus diesen Beispielsfällen werden sodann verallgemeinerungsfähige Rechtssätze zur Systembildung und zum Systemwechsel abgeleitet, die für weitere Fallkonstellationen eine Orientierung geben sollen. Die Untersuchung entwickelt dabei die bereits in früheren Schriften vorgenommene verfahrensrechtliche Systembildung dergestalt fort, dass dieses Verständnis nunmehr auch auf das materielle Gesellschaftsrecht erstreckt wird.
Transient and Sustained Ganglion Cell Light Responses Are Differentially Modulated by Intrinsically Produced Reactive Oxygen Species Acting upon Specific Voltage-Gated Na+Channel Isoforms
Authors: Smith Benjamin J. , McHugh Cyrus F. , Hirano Arlene A. , Brecha Nicholas C. , Barnes Steven 
Published: February 2023

Increasing spike rates drive greater neuronal energy demand. In turn, mitochondrial ATP production leads to the generation of reactive oxygen species (ROS) that can modulate ion channel gating. Does ROS production autoregulate the excitability of a neuron? We investigated the links between retinal ganglion cell (RGC) excitability and spike activity-driven ROS production in male and female mice. Changes to the light-evoked and current-evoked spike patterns of functionally identified αRGC subtypes, along with their NaVchannel-gating properties, were recorded during experimentally induced decreases and increases of intracellular ROS. During periods of highest spike rates (e.g., following light onset in ON sustained RGCs and light offset in OFF sustained RGCs), these αRGC subtypes responded to reductions of ROS (induced by catalase or glutathione monoethyl ester) with higher spike rates. Increases in ROS (induced by mercaptosuccinate, antimycin-A, or H2O2) lowered spike rates. In ON and OFF transient RGCs, there were no changes in spike rate during ROS decreases but increased ROS increased spiking. This suggests that endogenous ROS are intrinsic neuromodulators in RGCs having high metabolic demands but not in RGCs with lower energy needs. We identified ROS-induced shifts in the voltage-dependent gating of specific isoforms of NaVchannels that account for the modulation of ON and OFF sustained RGC spike frequency by ROS-mediated feedback. ROS-induced changes to NaVchannel gating, affecting activation and inactivation kinetics, are consistent with the differing spike pattern alterations observed in RGC subtypes. Cell-autonomous generation of ROS during spiking contributes to tuning the spike patterns of RGCs.SIGNIFICANCE STATEMENTEnergy production within retinal ganglion cells (RGCs) is accompanied by metabolic by-products harmful to cellular function. How these by-products modulate the excitability of RGCs bears heavily on visual function and the etiology of optic neuropathies. A novel hypothesis of how RGC metabolism can produce automodulation of electrical signaling was tested by identifying the characteristics and biophysical origins of changes to the excitability of RGCs caused by oxidizing by-products in the retina. This impacts our understanding of the pathophysiology of RGC dysfunction, supporting an emerging model in which increases in oxidizing chemical species during energy production, but not necessarily bioenergetic failure, lead to preferential degeneration of specific subtypes of RGCs, yielding loss of different aspects of visual capacity.
Serviço Social e formação em tempos de crise do capital e de pandemia
Authors: Araújo Laína Jennifer Carvalho , Joazeiro Edna Maria Goulart 
Published: February 2023

No Brasil, os retrocessos gerados pela crise capitalista no âmbito dos direitos sociais e das políticas sociais se intensificaram no contexto da crise sanitária causada pela pandemia da COVID-19, que desnudou as desigualdades sociais e consequentemente tem levado ao crescimento das necessidades sociais e de saúde dos segmentos da população. Essa conjuntura tem apresentado desafios a serem enfrentados no âmbito da intervenção, da ciência, da educação superior, da pesquisa e da formação, com destaque para a formação profissional do e no Serviço Social. É neste contexto que buscamos refletir sobre a formação profissional do assistente social, dando-se nas interfaces entre o processo formativo da e na universidade, e o fazemos mediado pelo desafio de construir propostas para o enfrentando no tempo presente desse contexto de crise do capitalismo e de pandemia da COVID-19. Trata-se de uma discussão analítica e conceitual com base na literatura especializada da temática.
A terminologia da crítica de arte a partir da Teoria Comunicativa da Terminologia
Authors: Oliveira Rodrigo Cássio 
Published: February 2023

Nosso objetivo é definir termos estéticos e explicar de que modo eles participam do léxico geral de uma língua a partir de uma abordagem interdisciplinar que correlaciona estética filosófica e linguística aplicada. Com base na Teoria Comunicativa da Terminologia, de Maria Teresa Cabré, defendemos que os termos estéticos operam em uma linguagem especializada na crítica de arte. Como conclusão, sustentamos que estudos empíricos sobre os termos estéticos podem se relacionar à fundamentação elaborada neste artigo e mencionamos alguns exemplos relevantes já publicados.