bluuebunny/crossref_metadata_2025_split huggingface dataset:
Medical ozone arrests oxidative damage progression and regulates vasoactive mediator levels in elderly patients (60–70 years) with oxidative etiology diseases
Authors: León Fernández Olga Sonia , Oru Gabriel Takon , Viebahn-Hänsler Renate , López Cabreja Gilberto , Serrano Espinosa Irainis , García Fernández Elizabeth 
Published: March 2023

Medical ozone reestablishes cellular redox balance so that it may be a valid therapeutic approach in the prevention and management of age-related diseases with oxidative etiology in older people. The aim of this study is to evaluate oxidative stress and some vasoactive substances in elderly (60–70 years) rheumatoid arthritis patients with diabetes and hypertension, as well as another group with bronchial asthma patients in order to demonstrate the beneficial effects of medical ozone in the prevention and therapy of age-related diseases in these age groups. A randomized clinical study with 45 older patients (60–70 years) was performed. Group I (n = 15) with rheumatoid arthritis + diabetes and hypertension received no ozone treatment, and group II (n = 30) was treated with medical ozone. This group was divided into two subgroups (n = 15 each), group IIa: the same as group I + medical ozone and group IIb: bronchial asthma patients. Indicators of RA in I and IIa groups were evaluated. Redox balance was assessed through defense and injury biomarkers. Thromboxane A2 (TXA2) and prostacyclin levels were assessed in group IIb patients. Medical ozone arrested oxidative injury progression in the Ia group and decreased thromboxane levels and the TXA2/6-keto PGF1α ratio in the IIb group. Medical ozone arrested the progression of oxidative damage and modulated those endogenous mechanisms that promote a suitable redox status and TXA2/PGI2 balance. These results suggest that medical ozone may become a standard approach in the prevention and management of age-related oxidative diseases in elderly people.
Longing for normalcy in couple relationships: How chronic illness and care dependency change the relationship of long-married couples
Authors: Niedling Katharina , Hämel Kerstin 
Published: March 2023

IntroductionCoping with chronic illness and care dependency in a marital dyad challenges many older couples. In our qualitative research study, we are interested in how long-married spouses in Germany experience their couple relationship while dealing with long-term care and adapting everyday life to the care situation.MethodsWe conducted problem-centered interviews with 17 spouses according to the interpretive-reconstructive documentary method.ResultsWe derived four thematic areas: (1) partner(ship) disappears behind the disease; (2) partners struggle with changing tasks and roles; (3) caring partners mourn the loss of intimacy; and (4) partners strive to rebalance the partnership.DiscussionWhen chronic illness and care dependency enter couples' lives, the self-image as husband or wife is affected. Primary health care professionals should be sensitive to the specific constellation of care in couple relationships and recognize the significance of this dyadic relationship as living in a satisfying couple relationship is essential for the health and wellbeing of both partners.
Effect of concurrent training on physical performance and quality of life in children with malignancy: A systematic review and meta-analysis
Authors: Zang Wanli , Fang Mingqing , Chen Haohao , Huang Xinmeng , Li Dong , Yan Jin , Shu Heng , Zhao Mingyuan 
Published: March 2023

ObjectiveThis study aims to evaluate the intervention effect of concurrent training on children with malignant tumors to provide evidence for prescribing exercise for children with malignant tumors.MethodsTwelve databases were searched from inception to October 15, 2022. Two researchers independently screened the literature, evaluated the quality, extracted the data, and performed the meta-analysis using R.ResultA total of nine randomized controlled trials involving 371 children were included in this study. The meta-analysis revealed that muscle strength was significantly greater in the exercise group compared to the usual care group [SMD = 0.26, 95% CI (0.04, 0.48), P = 0.023], with subgroup analysis showing no significant difference in upper limb [SMD = 0.13, 95% CI (−0.17, 0.43), P = 0.318] and a considerable difference in lower limb strength [SMD = 0.41, 95% CI (0.08, 0.74), P = 0.015]. Physical activity [SMD = 0.57, 95% CI (0.03, 1.1), P = 0.038], timed up and down stairs test [SMD = −1.22, 95% CI (−2.04, −0.4), P = 0.004], 6-min walking ability [SMD = 0.75, 95% CI (0.38, 1.11), P &lt; 0.01], quality of life [SMD = 0.28, 95% CI (0.02, 0.53), P = 0.033], and cancer-related fatigue [SMD = −0.53, 95% CI (−0.86, −0.19), P = 0.002] were significantly better than the usual care group. There were no significant differences in peak oxygen uptake [SMD = 0.13, 95% CI (−0.18, 0.44), P = 0.397], depression [SMD = 0.06, 95% CI (−0.38, 0.5), P = 0.791], and withdrawal rates [RR = 0.59, 95% CI (0.21, 1.63), P = 0.308] between the two groups.ConclusionConcurrent training could improve physical performance for children with malignancy but had no significant effect on mental health. Because the quality level of evidence is mostly very low, future high-quality randomized controlled trials are required to confirm these findings.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=364140, identifier CRD42022308176.
Comparative analysis of postoperative curative effect of liver wedge resection and liver IVb + V segment resection in patients with T2b gallbladder cancer
Authors: Wang Zichao , Liu Hongliang , Huang Yong , Wang Jun , Li Junjie , Liu Lingpeng , Huang Mingwen 
Published: March 2023

ObjectiveTo compare the therapeutic effects of wedge resection and liver segment IVb + V resection on patients with T2b gallbladder cancer.MethodsThe clinical and pathological data of 40 patients with gallbladder cancer admitted to the Second Affiliated Hospital of Nanchang University from January 2017 to November 2019 were retrospectively analyzed, and they were divided into two groups according to different surgical methods. The control group underwent liver wedge resection, while the experimental group underwent liver segment IVb + V resection. Preoperative age, bilirubin index, tumor markers, postoperative complications and survival were compared between the two groups. Log-rank test was used for univariate analysis, and Cox proportional hazards regression model was used for multivariate analysis. Kaplan-Meier survival curves were drawn.ResultsUnivariate analysis showed that tumor markers and degree of differentiation were the risk factors for the prognosis of patients with gallbladder carcinoma after radical cholecystectomy (P &lt; 0.05). Multivariate analysis showed that the elevation of CA125 and CA199, poor differentiation, and Lymph node metastasis were independent risk factors for the prognosis of gallbladder carcinoma after radical resection (P &lt; 0.05). According to the 3-year survival rate, the survival rate of patients with liver 4B + 5 segment resection + cholecystectomy was higher than that of patients with 2 cm liver wedge resection + cholecystectomy (41.6% vs. 72.7%).ConclusionPatients with T2b gallbladder cancer should be treated with liver segment IVb + V resection, which is helpful to improve the prognosis of patients and should be widely promoted.
Tandem mass tag-based quantitative proteomics analyses of a chicken-original virulent and its attenuated Histomonas meleagridis strain in China
Authors: Chen Qiao-Guang , Zhang Yu-Ming , Chen Chen , Wang Shuang , Li Zai-Fan , Hou Zhao-Feng , Liu Dan-Dan , Tao Jian-Ping , Xu Jin-Jun 
Published: March 2023

IntroductionHistomonas meleagridis can cause histomonosis in poultry. Due to the prohibition of effective drugs, the prevention and treatment of the disease requires new strategies. Questions about its pathogenic mechanisms and virulence factors remain puzzling.MethodsTo address these issues, a tandem mass tag (TMT) comparative proteomic analysis of a virulent strain and its attenuated strain of Chinese chicken-origin was performed.ResultsA total of 3,494 proteins were identified in the experiment, of which 745 proteins were differentially expressed (fold change ≥1.2 or ≤0.83 and p &lt; 0.05), with 192 up-regulated proteins and 553 down-regulated proteins in the virulent strain relative to the attenuated strain.DiscussionSurface protein BspA like, digestive cysteine proteinase, actin, and GH family 25 lysozyme were noted among the proteins up regulated in virulent strains, and these several proteins may be directly related to the pathogenic capacity of the histomonad. Ferredoxin, 60S ribosomal protein L6, 40S ribosomal protein S3, and NADP-dependent malic enzyme which associated with biosynthesis and metabolism were also noted, which have the potential to be new drug targets. The up-regulation of alpha-amylase, ras-like protein 1, ras-like protein 2, and involucrin in attenuated strains helps to understand how it is adapted to the long-term in vitro culture environment. The above results provide some candidate protein-coding genes for further functional verification, which will help to understand the molecular mechanism of pathogenicity and attenuation of H. meleagridis more comprehensively.
Les Russes de l'étranger proche : le thème diasporique et ses lobbies en Russie
Authors: Laruelle Marlène 
Published: March 2023

Russians from the "near abroad":
The theme of the diaspora and its lobbies in Russia
The place of Russians from the "near abroad" in Russian Federation politics is examined by studying the evolution of the theme of the "diaspora" since 1990 and the means used by lobbies for defending Russians. Since the second half of the 1990s, political authorities have addressed this issue. The implementation of the Repatriation Program in 2006-2007 provides evidence that the compatriots' issue in the near abroad has become part of the Russian state's new strategy to recover power. The theme of the diaspora is slowly being normalized as it leaves the field of radical nationalism to become the subject of a pragmatic approach.
Les Russes d'Ukraine : un enjeu lié à la définition de l'identité nationale
Authors: Dafflon Denis 
Published: March 2023

Russians in the Ukraine: An issue related to a national identity
Contrary to the fears of many political analysts at the time of independence, interethnic conflict has not occurred in Ukraine since 1991. The cultural proximity between Ukrainians and Russians has made it easier to integrate the latter, who make up nearly 20% of the population. Except for Crimea, Russians have voiced few demands over the past sixteen years. However the issue of the Russian language divides public opinion. This very emotional debate is related to the definition of a national identity and to the question of Ukraine's geopolitical orientation. Political parties, fully aware of the situation, are exploiting this issue for electoral purposes; and this has polarized voters.
Logiques de territorialité et de régionalisation en Europe de l'Ouest
Authors: Cole Alistair , Palmer Rosanne 
Published: March 2023

Territorially and regionalization in western Europe
In pursuit of a twofold, empirical and theoretical, objective, a panorama of regional phenomena in western Europe is presented that distinguishes four patterns in administering territories. A region's political capacity cannot be reduced to institutional resources; it fits into the larger history of relations between center and periphery. Following a critical review of the major studies in English and French on regional phenomena in Europe, three theoretical approaches are presented: the ethno-territorial constructivist current of thought, neoregionalism and multi-level governance. Light is shed on the advantages and limits of each.
Estudio de Caso en Regulación emocional de la terapia Dialéctica Conductual en paciente con diagnóstico de Trastorno de Personalidad Límite.
Authors: Chacón Retana Francisca Milena 
Published: March 2023

El Trastorno de Personalidad Límite (TPL) es uno de los trastornos de personalidad con mayor prevalencia en la población, la cual hace uso constante de los servicios de salud públicos y privados, debido a las estrategias de afrontamiento autodestructivas que presentan, y que generan riesgos graves tanto contra sí mismos (intentos de autolesión, conducta suicida), como contra sus allegados (agresividad, relaciones interpersonales caóticas, etc.).

El adecuado diagnóstico y uso de tratamientos basados en evidencia permiten la disminución de riesgos en los consultantes con TPL, la mayor adquisición de destrezas adaptadas a sus características de personalidad y la disminución de la consulta en los servicios de Emergencias.
En el presente estudio de caso clínico único, se describe el proceso diagnóstico realizado a una paciente mujer joven, la cual fue diagnosticada con TPL, así como con Otro Trastorno Depresivo No Especificado y Trastorno de Pánico, en remisión parcial. Se realizó un proceso terapéutico breve, el cual consistió en doce sesiones, donde se aplicaron principalmente técnicas para la enseñanza de habilidades de regulación emocional provenientes de la Terapia Dialéctica Conductual (TDC), acompañado de técnicas cognitivas conductuales, para la disminución de la sintomatología depresiva.
Zahirî Mezhebi Perspektifinde Cerh ve Ta’dil Meseleleri
Authors: KAYA Hüsamettin , BİLEN Mehmet 
Published: March 2023

Hadislerin sahihini sakiminden ayırmada muhaddislerin isnad kontrol sistemi olarak kullandığı cerh ve ta’dil ilmi, Zâhirîler nezdinde de önemli bir yere sahiptir. Zahirî âlimleri cerh ve ta’dil ilmine dair bilgiler verdikleri gibi râvi değerlendirmelerinde de bulunmuşlardır. Özellikle İbn Hazm ve İbnü’l-Kayserânî zikri geçen ilimde belli bir otoriteye sahip olmuşlardır. Zâhirîler, cerh ve ta’dilin önemiyle birlikte birçok hususa da değinmişlerdir. Cerhin müfesser olması kaidesi de bu hususlardan biridir. Onlara göre râvi değerlendirmelerindeki sübjektiflikten kurtulabilmek, cerhin nedenini açıklamakla mümkündür. Zira bir münekkidin nezdinde cerh sebebi olan eylem, başkasının yanında cerh nedeni olmayabilir. Örneğin hükmü ihtilaflı olan nebizin içilmesi nedeniyle cerh edilen râvi, bu kabildedir. Nitekim bu edim, nebîzi haram görenler için cerh sebebi iken onu mubah görenler için cerh sebebi değildir.
Zâhirî âlimleri, söz konusu hususun dışında bir râvide cerh ve ta’dilin taarruz etmesine de değinmişlerdir. Onlara göre böyle bir durumda cerh esas alınmalıdır. Çünkü cerhte bulunan münekkidin sahip olup da muaddilin râvi hakkında sahip olamadığı niteliklerin olması mümkündür. Mesela Süfyân es-Sevrî’nin Câbir el-Cu’fî’yi ta’dil etmesine karşın diğer münekkidler cerh etmiştir. Zâhirîler, râvi değerlendirmelerinde de birçok tabir kullanmışlardır. Ancak bu tabirlerin hiçbiri aşağılayıcı nitelikte olmamıştır. Ayrıca onlar, cerh ve ta’dilde söz sahibi olsalar da yeri geldiğinde bu ilmin mütehassıslarından da nakillerde bulunmaktadırlar.
PECULIARITIES OF THE IMMUNE SYSTEM IN NEWBORNS WITH INTRAUTERINE INFECTION WITH HERPESVIRUS INFECTION
Authors: ZHDANOVYCH R.I. 
Published: March 2023

The immune system, which normally participates in the maintenance of homeostasis, can be a trigger for pathological conditions caused by an overreaction or insufficient response to aggression, which are defined as immunopathological processes. In particular, the role of the immune system in brain damage has recently been discussed.
The purpose of the study is to determine the peculiarities of the immune system in newborns with intrauterine herpesvirus infection depending on the detected CNS disorders.
Material and Methods.90 children from mothers with herpesvirus infection with signs of intrauterine infection - the main group, which is divided into 2 subgroups: The first one - 35 children with signs of brain structure disorders detected by NSG examination, the second - 55 children who did not have such signs.
Results of the study. The cellular component of immunity (subpopulations of T- and B-lymphocytes in the blood) and cytokine profile (levels of interleukin-6 and interleukin-8 in the blood serum) were studied. The analysis of the immune status in children with intrauterine infection and CNS disorders revealed a hyperimmune immune response (increased content of natural killer cells, T-helper/T-suppressor ratio, levels of proinflammatory cytokines).
Conclusions. The damaging effect of hyperimmune reactions, the toxic effect of antigens is one of the pathogenetic links in the development of periventricular leukemia (due to blood-brain barrier disruption), which leads to a high incidence of CNS disorders.
FEATURES OF PRE-GRADUATION TRAINING OF FUTURE PARENTS AFTER THE EXPERIENCED DISEASE OF COVID–19.
Authors: MISHCHENKO V.P , LAVRINENKO A.L. , IBRAHIMOVA L.I. , SHVAGA M.YU. 
Published: March 2023

Timely personalized preparation for pregnancy has an important preventive, prognostic, clinical value for the further course of gestational processes. Pregnancy planning by expectant parents, in principle a man and a woman, becomes especially important in the conditions of the COVID-19 pandemic, taking into account the tropism of the SARS-Cov-2 (COVID-19) virus to the vascular endothelium.
The purpose of the study was to determine the features of pre-gravid preparation of future parents after suffering from the COVID-19 disease through the use of personalized preventive measures.
Research materials and methods. 42 women and 42 of their men of reproductive age who were sick with COVID-19 were examined. The main group is represented by 21 couples who planned pregnancy after personalized training. Pregnancy occurred spontaneously in a short time after the disease in the comparison group (21 married couples). The developed and proposed preconception preparation algorithm included a timely assessment of their somatic condition in the postcovid period, including hemostasiological blood parameters, markers of inflammation (ferritin, CRP, D-dimer), detection of accompanying infectious flora, and determination of the safest term through which to rationally recommend pregnancy planning, personalized pre-gravid preparation 3-4 months before expected natural fertilization.
Research results and their discussion. The presence of infectious processes in the body of women is a concomitant factor of the course of COVID-19 and the features of the clinical manifestations of the post-covid syndrome. Increased levels of markers of inflammation (ferritin, CRP, D-dimer) and decreased levels of vitamin D, magnesium are the basis for the pathogenetic justification of the stage of complex personalized preconception preparation.
Conclusions. Features of the pre-gravid preparation of future parents (male/female) after having experienced the disease of COVID-19 are: 1) timely assessment of their somatic condition in the post-covid period, including hemostasiological indicators of blood, markers of inflammation (ferritin, CRP, D-dimer), detection of accompanying infectious flora and determination of the safest period through which to rationally recommend pregnancy planning; 2) use according to the indications of preventive comprehensive personalized prevention and personalized pregravid preparation 3-4 months before the expected natural fertilization, including by taking vitamin macro-microelement amino acid complexes containing Methylfolate and continuing their intake throughout the gestation period. Indicators of the blood coagulation system were monitored by trimester of pregnancy.
FEATURES OF PREGNANCY WITH VIRAL HEPATITIS B
Authors: MUDRA YU. S. , SAVCHENKO S. YE. 
Published: March 2023

To date, insufficient data have been accumulated on the impact of maternal hepatitis B virus (HBV) infection on the course and outcomes of pregnancy, and data from published studies on this issue are contradictory.
The aim of the study. Determination of the features of the course of pregnancy, the state of the fetus and the newborn in viral hepatitis B.
Research materials and methods. 86 pregnant women with HBV were comprehensively examined (main group). 50 healthy pregnant women are included in the control group. Descriptive statistics methods used in biology and medicine were used.
Research results. The majority (67.4%) of patients with HBV are diagnosed with the inactive carrier phase, 27.9% with the replicative phase. Among obstetric and perinatal complications in women with HBV, early preeclampsia (30.2%) and the threat of abortion (29.1%), placental insufficiency (31.4%), gestational diabetes (17.4%), anemia I are most often noted and II half of pregnancy (26.7 and 29.1%), signs of fetal distress in the form of distress (26.7%) and growth retardation (14.1%). Polyhydramnios was observed in 17.4%. 2 (2.3%) cases of early pregnancy loss (miscarriage) were recorded. 20.9% of patients with hepatitis B were delivered surgically, premature birth occurred in 14.0% of patients. High frequency of fetal distress during childbirth (18.6%) and pathological blood loss (15.1%). 26.7% of women with HBV gave birth to asphyxiated children (2.3% had severe asphyxia). In 19.7% of cases, children were born with reduced body weight, in 11.6% - with signs of hypotrophy, in 8.1% of children signs of intrauterine infection were noted. Violations of the period of neonatal adaptation in the form of gastrointestinal syndrome, muscle hypotonia, increased neuroreflex excitability, thermoregulation disorders were observed in 18.6% of children. In 2 (2.3%) children born to women with HBV in the replication phase at a high level of viral load, intrauterine HBV infection was diagnosed, which was confirmed by positive PCR at 3 and 6 months.
Conclusions. Various obstetric and perinatal complications were observed in 38 (44.2%) pregnant women with HBV; further in-depth studies are needed to clarify the pathogenetic mechanisms of such disorders and identify risk factors.
Enhanced acoustic black hole energy harvesters with multipiezoelectric array designs
Authors: Xiong Defeng , Liang Jingfu , Qiao Yupei , Qi Shuibao 
Published: March 2023

Abstract
This study theoretically and numerically proposes vibroacoustic energy harvesting concepts based on acoustic black holes (ABHs) and piezoelectric materials. Various ABH configurations in planar structures have been explored and investigated from the perspective of flexural wave localization and energy confinement. Different piezoelectric energy transducers, attached to the center region of ABHs with loading circuits are designed. Energy harvester with arrayed two ABHs shows higher energy production density than a harvester with single ABH under the same driving conditions. The energy harvester with the combination of the arrayed ABHs and the multipiezoelectric arrays shows high output electrical power density and broadband features.