bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mixed‐phase WO3 Cocatalysts on Hierarchical Si‐based Photocathode for Efficient Photoelectrochemical Li Extraction
Authors: Jiang Li , Lyu Yanhong , Huang Aibin , Zheng Jianyun , Xie Chao , Cao Xun , Wang Shuangyin 
Published: April 2023

AbstractPhotoelectrochemical lithium (Li) extraction can be expected to provide a useful recycle of Li+ from waste Li‐containing battery, but the process is limited by the photocathodes with poor Li+ absorption and low yield rate. Here, we have designed a hierarchical silicon (Si)‐based photocathode with mixed‐phase tungsten oxide (WO3) cocatalysts for photoelectrochemical Li extraction under 1 sun illumination, achieving a high Li yield rate of ≈223.0 μg cm−2 h−1 and an excellent faradaic efficiency of 91.9 % at 0.0817 V versus Li0/+ redox couple. The WO3 cocatalysts with the mixture of amorphous and crystalline phase accelerates the Li+ insertion and precipitation and enriches the concentration of Li+ at the photocathode surface. This robust photoelectrochemical Li extraction system provides a new insight on designing green and efficient route for cyclic utilization of Li resources in the sustainable energy field.
Novel substituted 1,8‐naphthyridines: Design, synthesis, radiolabeling, and evaluation of apoptosis and topoisomerase II inhibition
Authors: Abuzahra Manar M. , Ahmed Nesreen S. , Sarhan Mona O. , Mahgoub Shahenda , Abdelhameed Ahmed , Zaghary Wafaa A. 
Published: April 2023

AbstractA series of seventeen 1,8‐naphthyridine derivatives (5a‐5q) conjugated at N1 to various substituted phenyl rings were designed and synthesized as potential topoisomerase II (Topo II) inhibitors. The antiproliferative activity of the target compounds against three cancer cell lines showed that compounds 5g and 5p had the highest antiproliferative activity. In addition, 5p and 5g displayed a high selectivity index (SI) for cancer cells when tested on WI38 normal cells, whereby compound 5p showed the highest SI. Furthermore, 5g and 5p induced cell cycle arrest at the S and G1/S phases, respectively, triggering apoptosis in HepG‐2 cells. The in vitro Topo II inhibitory effect (plasmid‐based) of both compounds revealed that 5p had better inhibition of Topo II. In addition, 5p displayed potent topoisomerase IIβ inhibitory effect when compared to known topoisomerase inhibitors (doxorubicin and topotecan). Molecular docking proposed a unique binding pattern of 5p in the etoposide binding pocket of topoisomerase IIβ, endorsing its potential role as a Topo II poison. Accordingly, 5p was chosen for radioiodination to study the degree of tumor localization following administration in solid tumor‐bearing mice. The radioiodinated 5p showed a selective localization at the tumor site, which further confirmed the value of 5p as a lead 1,8‐naphthyridine anticancer agent.
Initial diagnostic impressions of trainees during autism evaluations: High specificity but low sensitivity
Authors: de Marchena Ashley , Wieckowski Andrea Trubanova , Algur Yasemin , Williams Lashae N. , Fernandes Sherira , Thomas Rebecca P. , McClure Leslie A. , Dufek Sarah , Fein Deborah , Stahmer Aubyn C. , Robins Diana L. 
Published: April 2023

AbstractReducing the age of first autism diagnosis facilitates access to critical early intervention services. A current “waitlist crisis” for autism diagnostic evaluation thus demands that we consider novel use of available clinical resources. Previous work has found that expert autism clinicians can identify autism in young children with high specificity after only a brief observation; rapid identification by non‐experts remains untested. In the current study, 252 children ages 12–53 months presented for a comprehensive autism diagnostic evaluation. We found that junior clinicians in training to become autism specialists (n = 29) accurately determined whether or not a young child would be diagnosed with autism in the first five minutes of the clinic visit in 75% of cases. Specificity of brief observations was high (0.92), suggesting that brief observations may be an effective tool for triaging young children toward autism‐specific interventions. In contrast, the lower negative predictive value (0.71) of brief observations, suggest that they should not be used to rule out autism. When trainees expressed more confidence in their initial impression, their impression was more likely to match the final diagnosis. These findings add to a body of literature showing that clinical observations of suspected autism should be taken seriously, but lack of clinician concern should not be used to rule out autism or overrule other indicators of likely autism, such as parent concern or a positive screening result.
In‐depth analysis of patterns in selection of different physiologically‐based pharmacokinetic modeling tools: Part II — Assessment of model reusability and comparison between open and non‐open source‐code software
Authors: Aldibani Hamza Khaled Abdelmajed , Rajput Arham Jamaal , Rostami‐Hodjegan Amin 
Published: April 2023

AbstractWhilst the reproducibility of models in the area of systems biology and quantitative systems pharmacology has been the focus of attention lately, the concept of ‘reusability’ is not addressed. With the advent of the ‘Model Master File’ dominating some regulatory discussions on pharmaceutical applications of physiologically‐based pharmacokinetic (PBPK) models, reusability becomes a vital aspect of confidence in their use. Herein, we define ‘reusability’ specifically in the context of PBPK models and investigate the influence of open versus non‐open source‐code (NOSC) nature of the software on the extent of ‘reusability’. Original articles (n = 145) that were associated with the development of novel PBPK models were identified as source models and citations to these reports, which involved further PBPK model development, were explored (n > 1800) for reuse cases of the source PBPK model whether in full or partial form. The nature of source‐code was a major determinant of external reusability for PBPK models (>50% of the NOSC models as opposed <25% of open source‐code [OSC]). Full reusability of the models was not common and mostly involved internal reuse of the OSC model (by the group who had previously developed the original model). The results were stratified by the software utilised (various), organisations involved (academia, industry, regulatory), and type of reusability (full vs. partial). The clear link between external reuse of models and NOSC PBPK software might stem from many elements related to quality and trust that require further investigation, and challenges the unfounded notion that OSC models are associated with higher uptake for reuse.
Gastric cancer‐associated long non‐coding RNA profiling and noninvasive biomarker screening based on a high‐risk population cohort
Authors: Guo Xiaoying , Zhang Yang , Zhang Zhiyi , Lu Linzhi , Liu Yuqin , Li Zhexuan , Zhou Tong , Zhang Jingying , Li Wenqing , You Weicheng , Tao Guoquan , Chen Wanqing , Zeng Hongmei , Pan Kaifeng 
Published: April 2023

AbstractBackgroundEffective noninvasive biomarkers of gastric cancer (GC) are critical for early detection and improvement of prognosis. We performed genome‐wide long non‐coding RNA (lncRNA) microarray analysis to identify and validate novel GC biomarkers depending on a high‐risk population cohort.MethodsLncRNA profiles were described using the Human LncRNA Microarray between GC and control plasma samples. The differential candidate lncRNAs were validated in two stages by quantitative reverse transcription polymerase chain reaction (qRT‐PCR). We further evaluated the joint effect between the GC‐associated lncRNA and Helicobacter pylori (H. pylori) infection on the risk of cardia and non‐cardia GC, respectively.ResultsDifferent lncRNA expression profiles were identified between GC and control plasma with a total of 1206 differential lncRNAs including 470 upregulated and 736 downregulated in GC compared with the control group. The eight significantly upregulated lncRNAs (RP11‐521D12.1, AC011995.3, RP11‐5P4.3, RP11‐244 K5.6, RP11‐422 J15.1, CTD‐2306 M5.1, CTC‐428G20.2, and AC009133.20) in GC cases both in the present study and a similar microarray screening study by our collaborative team were selected for a two‐stage validation. After the large sample size validation, the subjects with higher expression of RP11‐244 K5.6 showed a significantly increased risk of GC with an adjusted odds ratio (OR) as 2.68 and 95% confidence interval (CI) as 1.15–6.24. Joint effects between RP11‐244 K5.6 expression and H. pylori infection on the risk of GC were evaluated with no statistical significance.ConclusionsOur study found different lncRNA expression profiles between GC and control plasma and preliminarily identified RP11‐244 K5.6 as a potential noninvasive biomarker for GC screening.
Clear cell renal cell carcinoma molecular variations innon‐HispanicWhite and Hispanic patients
Authors: Batai Ken , Chen Yuliang , Rheinheimer Brenna A. , Arora Amit , Pandey Ritu , Heimark Ronald L. , Bracamonte Erika R. , Ellis Nathan A. , Lee Benjamin R. 
Published: April 2023

AbstractBackgroundThe United States is becoming increasingly diverse, but few molecular studies have assessed the progression of clear cell renal cell carcinoma (ccRCC) in diverse patient populations. This study examined ccRCC molecular variations in non‐Hispanic White (NHW) and Hispanic patients and their effect on the association of gene expression with high‐grade (Grade 3 or 4) ccRCC and overall mortality.MethodsA total of 156 patients were included inVHLsequencing and/or TempO‐Seq analysis. DESeq2 was used to identify the genes associated with high‐grade ccRCC. Logistic regression analysis was performed to assess whether race and ethnicity was associated with high/moderate impactVHLsomatic mutations and the ccA/ccB subtype. Cox regression analysis was performed to assess association of molecular subtype and gene expression with overall mortality.ResultsNHWs had moderate or high impact mutations in theVHLgene at a higher frequency than Hispanics (40.2% vs. 27.4%), while Hispanics had a higher frequency of the ccA subtype than NHWs (61.9% vs. 45.8%). ccA was more common in patients with BMI≥35 (65.2%) than in those with BMI < 25 (45.0%). There were 11 differentially expressed genes between high‐ and low‐grade tumors. TheHaptoglobin(HP) gene was most significantly overexpressed in high‐ compared to low‐grade ccRCC in all samples (p‐adj = 1.7 × 10−12). When stratified by subtype, the 11 genes were significantly differentially expressed in the ccB subtype, but none of them were significant after adjusting for multiple testing in ccA. Finally, patients with the ccB subtype had a significantly increased risk of overall mortality (HR 4.87;p = 0.01) compared to patients with ccA, and patients with highHPexpression and ccB, had a significantly increased risk of mortality compared to those with lowHPexpression and ccA (HR 6.45,p = 0.04).ConclusionThis study reports ccRCC molecular variations in Hispanic patients who were previously underrepresented.
Communication transforms the impact of the COVID‐19 pandemic on children with cancer and their families
Authors: Ferrara Gia , Aguina Molly , Mirochnick Emily , Wiphatphumiprates Parima , Moreira Daniel C. , Sniderman Elizabeth , Villegas César A. , Kaye Erica C. , Ragab Iman , Maliti Biemba , Naidu Gita , Gassant Pascale Y. , Arce Daniela , Arora Ramandeep Singh , Alcasabas Ana Patricia , Raza Muhammad Rafie , Velasco Pablo , Kambugu Joyce , Vinitsky Anna , Rodriguez Galindo Carlos , Agulnik Asya , Graetz Dylan E. ,   and the COVIMPACT study group
Published: April 2023

AbstractBackgroundThe COVID‐19 pandemic altered healthcare systems globally, causing delays in care delivery and increased anxiety among patients and families. This study examined how hospital stakeholders and clinicians perceived the global impact of the COVID‐19 pandemic on children with cancer and their families.MethodsThis secondary analysis examined data from a qualitative study consisting of 19 focus groups conducted in 8 languages throughout 16 countries. A codebook was developed with novel codes derived inductively from transcript review. In‐depth analysis focused on the impact of the COVID‐19 pandemic on children with cancer and their families.ResultsEight themes describing the impact of the pandemic on patients and their families were identified and classified into three domains: contributing factors (COVID‐19 Policies, Cancer Treatment Modifications, COVID‐19 Symptoms, Beliefs), patient‐related impacts (Quality of Care, Psychosocial impacts, Treatment Reluctance), and the central transformer (Communication). Participants described the ability of communication to transform the effect of contributing factors on patient‐related impacts. The valence of impacts depended on the quality and quantity of communication among clinicians and between clinicians and patients and families.ConclusionsCommunication served as the central factor impacting whether the COVID‐19 pandemic positively or negatively affected children with cancer and families. These findings emphasize the key role communication plays in delivering patient‐centered care and can guide future development of communication‐centered interventions globally.
Real‐world comprehensive diagnosis and “Surgery + X” treatment strategy of early‐stage synchronous multiple primary lung cancer
Authors: Zhou Danting , Yao Tianyu , Huang Xiaojie , Wu Fang , Jiang Yi , Peng Muyun , Qian Banglun , Liu Wenliang , Yu Fenglei , Chen Chen 
Published: April 2023

AbstractBackgroundDiagnosing and treating synchronous multiple primary lung cancers (sMPLC) are complex and challenging. This study aimed to report real‐world data on the comprehensive diagnosis and treatment of patients with early‐stage sMPLC.Materials and MethodsA single‐center cohort study was carried out and a large number of patients with early‐stage sMPLC were included. A single‐ or two‐stage surgery was performed to remove the primary and co‐existing lesions. The “X” strategies, including ablation, SBRT, and EGFR‐TKIs treatment, were applied to treat the high‐risk residual lesions. Wide panel‐genomic sequencing was performed to assess the genetic heterogeneity of the co‐existing lesions.ResultsA total of 465 early‐stage sMPLC patients with 1198 resected lesions were included. Despite most patients being histologically different or harboring different genetic alternations, about 7.5% of the patients had the same histological type and driver gene mutation changes, comprehensive re‐evaluation is thus needed. The “Surgery + X” strategy showed remarkable efficacy and safety in treating multiple lesions. Follow‐up data revealed that the T2 stage (p = 0.014) and the solid presence of a primary lesion (p < 0.001) were significantly related to tumor recurrence. And a T2‐stage primary tumor had a significantly higher rate of developing new lesions after the initial surgery (p < 0.001).ConclusionsIn real‐world practice, histopathological and radiological evaluation combined with genetic analyses could be a robust diagnostic approach for sMPLC. The “Surgery + X” treatment strategy showed remarkable efficacy, superiority, and safety in the clinical treatment of early‐stage sMPLC.
Doing more with less: An integrative literature review on responsible consumption behaviour
Authors: Nangia Priya , Bansal Sanchita , Thaichon Park 
Published: April 2023

AbstractThe purpose of this research is to critically review the existing literature on responsible consumption behaviour (RCB) and identify the factors that influence it. Our findings are based on an integrative examination of 203 papers retrieved from the SCOPUS and WoS databases and analysed with the bibliometrix R software. Along with some descriptive insights into the field, we explain its intellectual structure informing future scholars about the field's evolution, and propose a future agenda for its advancement in the form, methodology, context, and themes. Five major themes emerged from our study: social values, corporate social responsibility (CSR), ethical obligations, environmental concern, and economic behaviour, which serve as a foundation for thematic future research directions. The implications for policymakers and management practice, as well as theoretical implications, are addressed.
Synthesis and Anti‐Inflammatory Activity Evaluation of Benzoxazole Derivatives as New Myeloid Differentiation Protein 2 Inhibitors
Authors: Bai Huiying , Cao Zhen , Meng Sha , Ge Rui , Ban Shurong , Zhang Yuanlin , Tang Li , Li Qing‐Shan 
Published: April 2023

AbstractMyeloid differentiation protein 2 (MD2), a key TLR4 adaptor protein for sensing LPS, plays an important role in inflammatory process and has been identified as a promising target for the treatment of a variety of inflammatory diseases. In our study, a series of benzoxazolone derivatives were synthesized, characterized and tested for anti‐inflammatory activity in vitro. The compounds 3c, 3d and 3g demonstrated the greatest anti‐inflammatory activity against IL‐6 with IC50 values of 10.14±0.08, 5.43±0.51 and 5.09±0.88 μM, respectively. Furthermore, the bis‐ANS displacement assay revealed that these compounds competitively inhibited the binding between the probe bis‐ANS and the MD2 protein. The most active compound 3g, revealed a directly bind with MD2 protein via Arg90 binding and a dissociation constant value of 1.52×10−6 mol L−1 as determined by the biological layer interference (BLI) assay. Our finding suggested that compounds 3g could be a promising lead compound as MD2 inhibitor for further anti‐inflammatory agent development.
Super twisting approach of a higher order sliding mode controller for a flyback DC–DC converter in photovoltaic applications
Authors: Waghmare Tushar T. , Chaturvedi Pradyumn 
Published: April 2023

SummarySolar photovoltaic (SPV) modules are frequently utilised to produce electricity. The output voltage and load power in SPV‐based applications are variable and strongly reliant on the operating conditions of solar energy, such as irradiance and ambient temperature. They offer additional challenges for the robust design of power converters, and DC–DC power converters provide the power bus with a constant voltage. Properties of a nonlinear system and load patterns necessitate a more robust control design for the power converter. This paper gives robust control of high‐order sliding mode (HOSM) control in isolated flyback converters for solar photovoltaic applications. The proposed HOSM technique is contrasted with the conventional PI control technique. The proposed HOSM control approach outperforms traditional PI control strategies under uncertainty and disturbance settings. This paper also presents a method for preventing chattering in flyback converters (FCs) using modified super twisting sliding modes.
How does spatial extent and environmental limits affect the accuracy of species richness estimates from ecological niche models? A case study with North American Pinaceae and Cactaceae
Authors: Nizamani Mir Muhammad , Papeş Monica , Wang Hua‐Feng , Harris AJ 
Published: April 2023

AbstractMeasuring species richness at varying spatial extents can be challenging, especially at large extents where exhaustive species surveys are difficult or impossible. Our work aimed at determining the reliability of species richness estimates from stacked ecological niche models at different spatial extents for taxonomic groups with vastly different environmental dependencies and interactions. To accomplish this, we generated ecological niche models for the species of Cactaceae and Pinaceae that occur within 180 published floras from North America north of Mexico. We overlaid or stacked the resulting species’ potential distribution estimates over the bounding boxes representing each of the 180 floras to generate predictions of species richness. In general, our stacked models of Cactaceae and Pinaceae were poor predictors of species richness. The relationships between observed and predicted values improved noticeably with the size of spatial extents. However, the stacked models tended to overpredict the richness of Cactaceae and over‐ and underpredict the richness of Pinaceae. Cactaceae stacked models showed higher sensitivity and lower specificity than those for Pinaceae. We conclude that stacked ecological niche models may be somewhat poor predictors of species richness at smaller spatial extents and should be used with caution for this purpose. Perhaps more importantly, abilities to compensate for their limitations or apply corrections to their reliability may vary with taxonomic groups.
Experimental verification for a mechanics‐based digital cloning method predicting structural performance and damage
Authors: Rabiepour Mohammad , Zhou Cong , Chase James Geoffrey 
Published: April 2023

AbstractThis paper introduces a novel digital twin modelling framework combining accurate structural health monitoring (SHM) results delivered by hysteresis loop analysis (HLA) with the basis function modelling to predict structural damage and responses of earthquake‐affected structures under future seismic events. The measured data sets of a 12‐storey 1/10 scale reinforced concrete (RC) structure shaken by three damaging base excitations (Events 1, 2 and 3) using a shake table has been employed to validate the performance of the introduced predictive framework. The results show that the digital twin created under the first base excitation (Event 1) predicts the inter‐storey displacement responses of the test structure due to the second and third excitations (Events 2 and 3) with an average correlation coefficient of ∼0.88 and ∼0.94, respectively. The inter‐storey drift ratio (IDR) values predicted by the digital twin also result in the same seismic performance delivered by the measured values, making the introduced framework a promising tool for assessing structural collapse and subsequent financial risk using incremental dynamic analysis (IDA). Moreover, the maximum difference of 5% between the identified and predicted stiffness values illustrates the robust and accurate performance of the proposed framework in diagnosing structural damage in highly nonlinear and damaged structures.