bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transradial cerebral angiography in the neonate and infant: a case series
Authors: Schoeman Sean , Pukenas Bryan , Escobar Fernando , Acord Michael , Cajigas-Loyola Stephanie , Vatsky Seth 
Published: January 2025

BackgroundWe aim to share our experience of transradial access (TRA) for cerebral angiography and intervention in five patients ranging from 6 days to 7 months of age.MethodsIn this institutional review board-approved, retrospective case series, we reviewed all patients who underwent TRA for cerebral angiography with and without intervention. We describe three techniques for radial artery cannulation, namely: (1) bareback; (2) with a micropuncture sheath; and (3) with an intravenous catheter. Demographic, clinical, procedural, and imaging data were abstracted from the patients’ medical records.ResultsFrom September 2019 to August 2023, five patients (median age and weight, 24 days (range 6–218 days) and 4.2 kg (range 3.2–6.2 kg)) underwent TRA for cerebral angiography. Four patients underwent diagnostic cerebral angiography, two via left TRA and two via right TRA. One patient was definitively treated with endovascular embolization for an arteriovenous fistula. Median procedural length was 1.5 hours (range 1–2.2 hours) and median effective skin dose was 88.7 mGy (range 48.8–140.3 mGy). No procedures required conversion to femoral artery access to obtain diagnostic quality imaging or to facilitate intervention. No complications related to the accessed radial artery were recorded.ConclusionsWe have demonstrated that TRA in the neonate and infant is feasible. In our experience this technique is safe and effective for diagnostic cerebral angiography. Additionally, select intervention via TRA in this population may be possible as demonstrated by our single example of endovascular management of an intracranial fistula.
Clinically relevant haemolysis after transcatheter aortic valve implantation with new-generation balloon-expandable valve
Authors: Higuchi Ryosuke , Takamisawa Itaru , Kitamura Mitsunobu , Nanasato Mamoru , Ohno Makoto , Isobe Mitsuaki 
Published: January 2025

BackgroundValve-related haemolysis is a known complication following prosthetic valve surgery. Haemolysis after transcatheter aortic valve implantation (TAVI) has been reported in some studies, all of which were non-critical. Data related to haemolysis associated with new-generation balloon-expandable valve (BEV) are scarce.MethodsAmong 441 patients who underwent TAVI between April 2023 and June 2024, 282 patients treated with new-generation BEV were analysed. Haemolysis was defined based on the lactate dehydrogenase, haemoglobin, reticulocyte and haptoglobin levels. Clinically relevant haemolysis was defined as a case requiring transfusion and/or reintervention.ResultsClinically relevant haemolysis occurred in 6 of 282 patients (2.1%), with median age of 84 years. Three (50%) received a 20 mm valve, and the oversizing ranged from −6.6% to +2.7%. All patients (100%) exhibited paravalvular leakage at the native commissural sites, with moderate or greater paravalvular leakage in two (33%). Lactate dehydrogenase levels exceeded 1200 IU/L in five (83%), four (67%) required transfusion and three (50%) underwent reintervention: balloon aortic valvuloplasty in one and valve-in-valve procedures in two. Haemolysis regressed in three reintervention cases; however, one patient died 9 days postoperatively due to COVID-19. Among three patients (50%) managed conservatively, one developed prosthetic valve endocarditis, whereas another showed spontaneous regression of haemolysis. Over a median follow-up of 218 days, five patients (83%) survived.ConclusionClinically relevant haemolysis occurred in 2.1% of patients undergoing TAVI with new-generation BEV, with 67% requiring transfusion and 50% undergoing reintervention. Further research is warranted to identify risk factors and optimise management strategies for haemolysis.
Low apolipoprotein A1 and high apolipoprotein B levels indicate specific lipid changes in treatment naïve early psoriatic arthritis
Authors: Ishchenko Alla , Van Mechelen M , Storms Lies , de Vlam Kurt , Pazmino Sofia , Neerinckx Barbara , Verschueren P , Lories Rik 
Published: January 2025

ObjectivesTo investigate serum lipid profile in early, treatment-naïve psoriatic arthritis (PsA) and to determine whether changes in classical lipids or apolipoproteins are specific to PsA.MethodsTotal cholesterol, non-high-density lipoprotein cholesterol (non-HDL-c), low-density lipoprotein cholesterol (LDL-c), HDL-c, triglycerides, apolipoprotein B (ApoB) and apolipoprotein A1 (ApoA1) were compared in newly diagnosed untreated PsA patients (n=75) to sex- and age-matched controls (healthy control (HC)) (n=61) and early untreated rheumatoid arthritis (RA) patients (n=50).ResultsAmong classical lipid measurements, HDL-c levels were lower in PsA than in HC and RA (df 2, χ210, p=0.006, PsA vs HC p=0.013). Significant differences in ApoA1 and ApoB levels were observed between PsA, RA and controls. ApoB was higher in PsA than in RA patients but lower than in controls (df2, χ243.8; p<0.001). ApoA1 was markedly lower in PsA patients compared with both RA and controls (df2, χ2118.9; p<0.001). In regression models, the levels of ApoA1, adjusted for additional factors, were predictive of PsA diagnosis with 90.6% accuracy. In receiver operating characteristic analysis, ApoA1 was predictive of the diagnosis of PsA with a specificity of 82.4% and a sensitivity of 83.8% at an optimal cut-off value of 1403 µg/mL (area under the curve (95% CI), 0.886 (0.83 to 0.941)).ConclusionEarly, treatment-naïve PsA patients exhibit a distinct pro-atherogenic lipid profile, characterised by decreased ApoA1 and increased ApoB levels, distinguishing them from early RA patients and healthy controls. These findings highlight the potential of apolipoprotein measurements to serve as more accurate indicators of lipid disturbances in PsA than traditional serum lipids and as aid to diagnosis of patients presenting with early arthritis.
Evaluating equity reporting within systematic reviews of pre-exposure prophylaxis (PrEP)
Authors: Paris Bethany , Batioja Kelsi , Lin Vanessa , Hartwell Micah 
Published: January 2025

BackgroundPre-exposure prophylaxis (PrEP) is a medicine that can reduce HIV transmission. Given the disproportionate impact of HIV on minority communities, health equity is an important consideration in PrEP research. We aimed to assess equity reporting in systematic reviews of PrEP using the PROGRESS Plus framework.MethodsWe conducted a systematic search of PubMed (MEDLINE), Embase and Cochrane databases for systematic reviews or meta analyses of PrEP usage. We then used the PROGRESS Plus framework to extract inclusion of the following domains: place of residence, race/ethnicity/culture/language, occupation, gender/sex, religion, education, socioeconomic status, social capital, age and disability.ResultsAfter screening search articles, our sample included 36 systematic reviews and meta-analyses (SRMAs). 24 (66.7%) were conducted within the USA. Few (2/36, 5.6%) were found to mention adherence to any equity reporting framework. Place and gender/sex were the most reported elements of the framework with inclusion in 34 of 36 studies. Age (30/36, 83.3%) and race/ethnicity (24/36, 66.7%) were also commonly reported. All other criteria were reported in less than half of included SRMAs; religion had the lowest inclusion at 0/36 (0%), followed by disability (1/36, 2.8%). Among the 36 SRMAs, 19 (52.78%) did not conduct any subgroup analyses among domains; those most commonly analysed were gender/sex and age.ConclusionOur study found nearly all SRMAs regarding HIV PrEP reported on gender/sex and age; however, other influential equity criteria were often overlooked. Further attention to the reporting of PROGRESS Plus items within these SRMAs may reduce barriers for PrEP utilisation, thus improving HIV prevention strategies.
Independent companies in the tobacco supply chain: transparency and environmental social governance
Authors: Dunwoodie Stirton Fred , Hiscock Rosemary , Mehegan John , Gallagher Allen W A , Bloomfield Michael J 
Published: January 2025

ObjectivePrevious research has identified that transnational tobacco companies lack transparency and that they hide their harms to health and nature behind environmental, social and governance (ESG) reporting. Our objective was to find whether independent tobacco supply chain companies similarly lack transparency on tobacco-related activities while prominently displaying ESG.MethodsIn this cross-sectional study, mentions of tobacco supply chain activities and ESG company official documentation and websites were explored for independent tobacco supply chain companies (n=80) with identified annual reports included in the Tobacco Supply Chain Database. Bivariable statistical analysis tested for differences in the visibility of tobacco supply chain contribution and ESG within official documents and websites. In depth exploration was undertaken for seven case study companies.ResultsIndependent tobacco supply chain companies were significantly less likely to mention their tobacco supply chain contribution than ESG (31% and 80%, respectively p<0.001) in annual reporting. Tobacco supply chain contribution was also less prominent than ESG on websites (29% and 79%, respectively, mentioned on the home page or a home page menu p<0.001). The companies were making median annual profits of over US$2 million (n=76), with a large variation of revenue from tobacco activity (5–100%) where it was reported (n=9).ConclusionsIndependent tobacco supply chain companies undertake ESG activities that they prominently display in official reporting and on websites while often being less transparent about their tobacco supply chain contribution. Potential investors and customers may thus be misled about the companies’ true nature. More rigorous reporting requirements are needed.
Parents’ COVID-19 stressors and associations with self-rated health, symptoms of mental health problems, and substance use: a cross-sectional study
Authors: Fortier Janique , Salmon Samantha , Taillieu Tamara , Stewart-Tufescu Ashley , MacMillan Harriet L. , Tonmyr Lil , Gonzalez Andrea , Kimber Melissa , Roos Leslie , Sareen Jitender , Afifi Tracie O. 
Published: January 2025

The aim of this study was to understand associations between pandemic stressors and parents’ self-rated physical and mental health; symptoms of mental health problems, and at-risk substance use problems. Data were collected from February 2022 to March 2022 as part of Wave 2 of the Well-being and Experiences Study in Manitoba, Canada ( n = 749). Stressors frequently identified since the onset of the pandemic included inability to spend time with family and friends, worry about getting coronavirus disease-2019 (COVID-19), and travel restrictions. In the past month, the most frequently identified stressors were worry about getting COVID-19, travel restrictions, public health restrictions, and worry about the future. The stressors with the greatest number of associations with worse health outcomes included: job loss or financial burden; feeling lonely or isolated; disrupted or poor sleep; uncertainty about the future; accessing health care for any reason; increased conflict in relationships; cancellation of surgeries, caregiving for children; and inability to spend time with family. Understanding the COVID-19 stressors that were associated with health and substance problems can inform clinical approaches to respond to pandemic-related problems, as well as public health preparedness to mitigate declines in parents’ health and well-being in the context of future pandemics.
Projected background and sensitivity of AMoRE-II
Authors: Agrawal A. , Alenkov V. V. , Aryal P. , Beyer J. , Bhandari B. , Boiko R. S. , Boonin K. , Buzanov O. , Byeon C. R. , Chanthima N. , Cheoun M. K. , Choe J. S. , Choi Seonho , Choudhury S. , Chung J. S. , Danevich F. A. , Djamal M. , Drung D. , Enss C. , Fleischmann A. , Gangapshev A. M. , Gastaldo L. , Gavrilyuk Y. M. , Gezhaev A. M. , Gileva O. , Grigorieva V. D. , Gurentsov V. I. , Ha C. , Ha D. H. , Ha E. J. , Hwnag D. H. , Jeon E. J. , Jeon J. A. , Jo H. S. , Kaewkhao J. , Kang C. S. , Kang W. G. , Kazalov V. V. , Kempf S. , Khan A. , Khan S. , Kim D. Y. , Kim G. W. , Kim H. B. , Kim Ho-Jong , Kim H. J. , Kim H. L. , Kim H. S. , Kim M. B. , Kim S. C. , Kim S. K. , Kim S. R. , Kim W. T. , Kim Y. D. , Kim Y. H. , Kirdsiri K. , Ko Y. J. , Kobychev V. V. , Kornoukhov V. , Kuzminov V. V. , Kwon D. H. , Lee C. H. , Lee DongYeup , Lee E. K. , Lee H. J. , Lee H. S. , Lee J. , Lee J. Y. , Lee K. B. , Lee M. H. , Lee M. K. , Lee S. W. , Lee Y. C. , Leonard D. S. , Lim H. S. , Mailyan B. , Makarov E. P. , Nyanda P. , Oh Y. , Olsen S. L. , Panasenko S. I. , Park H. K. , Park H. S. , Park K. S. , Park S. Y. , Polischuk O. G. , Prihtiadi H. , Ra S. , Ratkevich S. S. , Rooh G. , Sala E. , Sari M. B. , Seo J. , Seo K. M. , Sharma B. , Shin K. A. , Shlegel V. N. , Siyeon K. , So J. , Sokur N. V. , Son J. K. , Song J. W. , Srisittipokakun N. , Tretyak V. I. , Wirawan R. , Woo K. R. , Yeon H. J. , Yoon Y. S. , Yue Q. ,   The AMoRE Collaboration
Published: January 2025

AbstractAMoRE-II aims to search for neutrinoless double beta decay ($$0\nu \beta \beta $$

0
ν
β
β

) with an array of 423 $$\hbox {Li}_2^{100}\hbox {MoO}_4$$

Li
2
100

MoO
4

crystals operating in the cryogenic system as the main phase of the Advanced Molybdenum-based Rare process Experiment (AMoRE). AMoRE has been planned to operate in three phases: AMoRE-pilot, AMoRE-I, and AMoRE-II. AMoRE-II is currently being installed at the Yemi Underground Laboratory, located approximately 1000 m deep in Jeongseon, Korea. The goal of the experiment is to reach an exclusion half-life sensitivity to the $$0\nu \beta \beta $$

0
ν
β
β

of $$^{100}$$

100

Mo on the level of $$T^{0\nu \beta \beta }_{1/2} > 6 \times 10^{26}$$

T

1
/
2

0
ν
β
β

>
6
×

10
26

year that covers completely the inverted Majorana neutrino mass hierarchy region of (15–46) meV. To achieve this, the background level of the experimental configurations and possible background sources of gamma and beta events should be well understood. We have intensively performed Monte Carlo simulations using the GEANT4 toolkit in all the experimental configurations with potential sources. We report the estimated background level that meets the $$10^{-4}$$

10

-
4

counts/(keV$$\cdot $$
·
kg$$\cdot $$
·
year) requirement for AMoRE-II in the Region Of Interest (ROI) and show the projected half-life sensitivity based on the simulation study.
The Microbiology, Management and Outcomes of Native Joint Septic Arthritis of the Hand in Adults of Southeast Queensland
Authors: FORMAN Lee , FORMAN Ariadne , ALCORN Kylie 
Published: January 2025

Background: Native joint septic arthritis (NJSA) of the hand is poorly studied. Management guidelines are extrapolated from large joint infections despite differences in epidemiology, anatomy and aetiology. Limited evidence suggests shorter courses of antibiotics can achieve outcomes comparable to longer courses. The aim of our study is to characterise the presentation, management and outcomes of NJSA of the hand in an adult cohort from Southeast Queensland (SEQ) and determine if the route or duration of antibiotics affected the outcome. Our cohort was compared to those in the literature to determine if already published data could be applicable to our population. Methods: A coding based retrospective cohort of adult patients between 2016 and 2022 were assessed. The cohort was divided into short/long course antibiotics and primarily intravenous/oral route for outcome comparison. Results: Seventy-four patients were included with a joint culture positive rate of 75%. The most common aetiology of infection was direct trauma and the most common pathogen was Staphylococcus aureus. Resolution was achieved in 86% of patients after 1-year follow-up, with a median antibiotic duration of 14 days, and 48% had non-infectious sequelae. Failure to achieve resolution was associated with females and taking immunosuppressants. No significant difference was detected when analysed for primary route or duration of antibiotics. Conclusions: There was no difference in the rate of resolution attributable to the route or duration of antibiotics. We demonstrated comparability between our cohorts’ demographics, management and outcomes with those in the literature. Based on the findings in our study, noting the retrospective nature and small cohort, the authors conclude for uncomplicated NJSA of the hand, a total antibiotic duration of 14 days in addition to early surgical intervention is likely to be successful in most patients. Level of Evidence: Level III (Therapeutic)
The Initial Characteristics of Paediatric Supracondylar Humerus Fractures Led to Cubitus Varus Deformity and Delayed Displacement
Authors: TAKAGI Takehiko , AIBARA Noriyuki , YAMAGUCHI Sakura , SEKI Atsuhito , TAKAYAMA Shinichiro 
Published: January 2025

Background: Supracondylar humerus fractures are the most common type of elbow fracture in children, with a variety of complications such as cubitus varus deformity. The most important goal of the initial treatment is to avoid complicated deformities. In the present study, we investigated cubitus varus deformity and discussed the ideal initial treatment for supracondylar humerus fractures. Methods: There were 58 conservative cases (26 girls and 32 boys) and 115 operative cases (40 girls and 75 boys) with supracondylar humerus fractures. We evaluated the correlation between the following factors on injury in the conservative cases: Gartland classification, presence of comminuted medial fractures, medial shift length, anterior spike length, age, sex, affected side (as explanatory variables) and the factors of cubitus varus deformity as response variables by using the linear regression model for multivariable analysis. Moreover, we evaluated the changes in displacement after the operation in the operative cases, adding the presence of medial pins and the number of pins as explanatory variables. Results: Injury severity (Gartland classification) was a significant factor for cubitus varus deformity. The presence of comminuted bone fragments on the medial side, anterior spike length, age, sex and affected side were not significant factors of cubitus varus deformity. However, medial displacement on injury was a significant factor of both cubitus varus deformity. In the operative case study, medial displacement was a significant factor in cubitus varus deformity. The presence of comminuted bone fragments on the medial side, number of pins and age were also significant factors for cubitus varus deformities. Conclusions: The present study concluded that it is important to perform accurate reduction and fixation, with special attention to medial shift and medial comminuted fragments to avoid cubitus varus deformity. Level of Evidence: Level IV (Therapeutic)
Tracking Nongenetic Evolution from Primary to Metastatic ccRCC: TRACERx Renal
Authors: Fernández-Sanromán Ángel , Fendler Annika , Tan Benjy J.Y. , Cattin Anne-Laure , Spencer Charlotte , Thompson Rachael , Au Lewis , Lobon Irene , Pallikonda Husayn Ahmed , Martin Alice , Byrne Fiona , Franz Antonia , Mikolajczak Anna , Rahman Haseeb , Tippu Zayd , Shepherd Scott T.C. , Feng Hugang , Deng Daqi , Rowan Andrew , Pickering Lisa , Furness Andrew J.S. , Young Kate , Nicol David , Rudman Sarah Maria , O’Brien Tim , Edmonds Kim , Chandra Ashish , Hazell Steve , Litchfield Kevin , Kassiotis George , Larkin James , Turajlic Samra 
Published: January 2025

Abstract
Although the key aspects of genetic evolution and their clinical implications in clear-cell renal cell carcinoma (ccRCC) are well documented, how genetic features coevolve with the phenotype and tumor microenvironment (TME) remains elusive. Here, through joint genomic–transcriptomic analysis of 243 samples from 79 patients recruited to the TRACERx Renal study, we identify pervasive nongenetic intratumor heterogeneity, with over 40% not attributable to genetic alterations. By integrating tumor transcriptomes and phylogenetic structures, we observe convergent evolution to specific phenotypic traits, including cell proliferation, metabolic reprogramming, and overexpression of putative cGAS–STING repressors amid high aneuploidy. We also uncover a coevolution between the tumor and the T-cell repertoire, as well as a longitudinal shift in the TME from an antitumor to an immunosuppressive state, linked to the acquisition of recurrently late ccRCC drivers 9p loss and SETD2 mutations. Our study reveals clinically relevant and hitherto underappreciated nongenetic evolution patterns in ccRCC.

Significance:
Using joint genomic–transcriptomic analysis of 243 samples, we reveal recurrent patterns of nongenetic evolution in ccRCC not exclusively governed by genetic factors, including T-cell depletion, tumor T-cell receptor coevolution, potential cGAS–STING repression, and increased cell proliferation. These patterns can aid clinical management and guide novel treatment approaches.
A (trans)formação dos seres viventes em Bugônia, de Daniel Galera
Authors: Ferreira Letícia Vital 
Published: January 2025

This article proposes an ecocritical reading of the novel Bugônias (2022), by Daniel Galera. To this end, an updated critical contribution was mobilized to enable the analysis of the participation of different living beings in the narrative, highlighting metamorphosis as a manifestation of inter and intra-species alliances. The presentation of animals as agents and as capable of language enables readings of the novel that move away from speciesism. Furthermore, the journey of the character Chama is studied from the perspective of a coming-of-age story, altering some of the perspectives present in traditional romance novels. Finally, it is argued that the Organism also participates in this formative process, becoming a sympoetic system.
Who Forgives Sins but God? None, One, or Many?
Authors: Henning Bruce 
Published: January 2025

Abstract
In the wider scope of Luke-Acts, the forgiveness of the paralyzed man (Luke 5:17–26) is similar to Matthew’s (9:1–8) not only in presenting Jesus as God’s agent of forgiveness but in including the disciples in this work as well. Three intratextual connections support this interpretation: the proclamation of forgiveness in Luke 4:18 as part of the Isaianic servant’s mission that is fulfilled by disciples elsewhere in Luke-Acts; the call of the fishermen (Luke 5:1–11) that establishes disciples as Jesus’ agents; and the healing in Acts 3–4 that parallels the episode, so that Peter’s miracle demonstrates that he too has authority, but only in Jesus’ name.
Effects of personalized 3D-printed blocks in total knee arthroplasty and revision surgery for massive bone defects: a single-center retrospective study
Authors: Lu Fei , Li Congsun , Hu Pengfei , Hu Bin , Wu Haobo 
Published: January 2025

Objective To analyze the early- to mid-term clinical efficacy of personalized 3D-printed structural metal spacer technology in reconstructing massive bone defects during complex total knee arthroplasty (TKA) and revision surgery. Methods A single-center retrospective study was conducted on nine patients with severe bone defects who underwent TKA between 2018 and 2024. The general condition, surgical details, and clinical improvement of these patients were recorded and analyzed by clinical doctors. Results The average surgical duration was 183.9 minutes (range, 125–240 minutes), with intraoperative blood loss of 133.3 mL (range, 100–200 mL). The average hospital stay was 18.2 days (range, 10–42 days), and the follow-up duration was 13.2 months (range, 2–57 months). The preoperative average American Knee Society Score of 51.2 points (range, 15–74 points) improved significantly to 95.0 points (range, 81–106 points) at the last follow-up. No cases of vascular or nerve injury, infection, fracture, or prosthetic loosening were observed. Conclusion The precise manufacturing of customized spacers that seamlessly integrate with the patient’s skeletal structure ensures stability, adaptability, and improved surgical outcomes.