bluuebunny/crossref_metadata_2025_split huggingface dataset:
Outcomes of vertex‐vertex vs. vertex‐breech presentation in twin pregnancy after vaginal delivery in China
Authors: Liu Huahua , Yan Shuhan , Wu Fan , Bai Ting , Zhang Feng 
Published: July 2023

AbstractObjectiveTo compare the maternal and neonatal outcomes of twin pregnancies between vertex and nonvertex presentations of the second twin in vaginal delivery.MethodsIn this unicentric retrospective cohort study, we collected data from 213 cases of vaginal twin deliveries from January 2016 to July 2020. Participants were divided into the vertex‐vertex presentation group (VV) and vertex‐breech presentation group (VB). Data on maternal and neonatal outcomes were compared between groups.ResultsAmong the 213 mothers and 426 infants (213 twin pairs), there were 140 women in the VV group and 73 women in the VB group (65.73% vs. 34.27%). Infants in the VB group had a higher incidence of admission to NICU (51.43% vs. 68.49%, p = 0.017), lower 1‐min (11.43% vs. 28.77%, p < 0.001) and 5‐minute Apgar scores (1.43% vs. 4.11%, p = 0.043) for the second twin. However, after the adjustment for sex of the twin, birth weight, chorionicity, and gestational age, the greater risk of admission to NICU and low 5‐min Apgar score was no longer significantly different.ConclusionVB twins are at no greater overall risk of a poor outcome due to breech presentation in the second twin. However, the presentation of the second fetus represents a risk factor for a low 1‐min Apgar score. Obstetricians and midwives should consider appropriate interventions for second twins who present breech versus vertex.
Bleeding risk with concurrent use of anticoagulants and ibrutinib: A population‐based nested case‐control study
Authors: Allouchery Marion , Tomowiak Cécile , Singier Allison , Puyade Mathieu , Dari Loubna , Pambrun Elodie , Pariente Antoine , Bezin Julien , Pérault‐Pochat Marie‐Christine , Salvo Francesco 
Published: July 2023

SummaryData regarding the safety of co‐administration of ibrutinib with anticoagulants in real‐life settings are scarce. Using a nationwide database, we conducted a nested case‐control study in a cohort of new users of ibrutinib to assess the risk of clinically relevant bleeding (CRB) associated with anticoagulation. Cases were patients with a diagnosis of CRB, defined as hospitalization with a diagnosis of bleeding. The date of CRB constituted the index date. Up to four controls were matched on sex, age at index date and duration of follow‐up. The risk of CRB associated with anticoagulation in patients receiving ibrutinib was estimated using conditional logistic regression models, providing odds ratios (OR) adjusted for risk factors of bleeding. Among 614 cases and 2407 matched controls, the risk of CRB was significantly higher in patients receiving both ibrutinib and anticoagulants (adjusted OR [aOR] 2.54, confidence interval [CI] 95% [1.94; 3.32]). When considering anticoagulant class, aOR was 1.99 (CI 95% [1.19; 3.33]) for VKA, 2.48 (CI 95% [1.76; 3.47]) for direct oral anticoagulants and 3.40 (CI 95% [2.01; 5.75]) for parenteral anticoagulants. In conclusion, this study found a 2.5‐fold increased risk of CRB in patients receiving both ibrutinib and anticoagulants in real‐life settings, and similar aOR among oral anticoagulants.
A step to disentangle diversity patterns in Uruguayan grasslands: Climatic seasonality, novel land‐uses, and landscape context drive diversity of ground flora
Authors: Säumel Ina , Ramírez Leonardo R. , Santolin Julia , Pintado Karla 
Published: July 2023

AbstractSouth American grasslands contain extraordinary biodiversity and play a central role in the subsistence of regional agroecosystems. In recent decades, afforestation, followed by the soybean planting boom, have led to drastic land‐use changes at the expense of grasslands. Impacts on local biodiversity have remained understudied. We explored the taxonomic richness and ß‐diversity of plants of ground layer (excluding trees and shrubs) at different land uses, its interplay at regional scale with environmental heterogeneity, and at local scale with novel land cover types and landscape configurations. We conducted correlation, principal component, NDMS, and SDR analysis to explore variation of taxonomic richness, richness difference, replacement, and similarity of ground flora as response to environmental filters and land use change across Uruguay. We surveyed 160 plots distributed in 10 land cover types, that is, closed and open native forests, different grasslands, crops, orchards, and timber plantations. We observed overlaying regional patterns driven by seasonality of temperature and precipitation, and land cover shaping taxonomic richness at local scale. Landscape configuration affects diversity patterns of native ground flora, which seems to be sustained mainly by the “old growth grassland” species pool. Taxonomic richness of native species decreases with an increase of distance to grassland. Crops and grasslands harbor a higher number of native species in the ground flora than native forests and timber plantations. The introduction of exotics is driven mostly by crops or highly modified pastures. Diversity patterns only partially reflect the ecoregion concept. Expanding the perspective from conservation in purely natural ecosystems to measures conserving species richness in human‐modified landscapes is a powerful tool against species loss in the Anthropocene.
Substance use trajectories among emerging adult Black men: Risk factors and consequences
Authors: Kwon Elizabeth , Oshri Assaf , Zapolski Tamika C. B. , Zuercher Heather , Kogan Steven M. 
Published: July 2023

AbstractIntroductionYoung, Black American men experience greater social, legal and economic consequences of substance use compared with White men for comparable levels of consumption. The development of tailored interventions requires prospective information on their substance use patterns, risk factors and consequences. We identified longitudinal substance use profiles and examined their links to childhood adversity, racial discrimination and young adult problem substance use and mental health.MethodsEmerging adult Black men (n = 504, mean age = 20.26, SD = 1.08) provided fours waves of data between January 2012 and March 2021. We conducted a parallel process latent class growth analysis for three substances to explore conjoint longitudinal use patterns and investigated the risk factors and consequences of each pattern.ResultsThree trajectory classes emerged: non‐using (n = 201, 39.9%), cannabis using (n = 202, 40.1%) and poly‐substance using (n = 101, 20%) groups. Threat‐based childhood adversity and racial discrimination were associated with higher odds of being members of cannabis or poly‐substance groups than non‐using group. Deprivation‐based adversity was associated with higher odds for membership in poly‐substance than non‐using group. At Wave 4, elevated depressive symptoms were more prevalent among poly‐substance compared with cannabis using group.Discussion and ConclusionsHeterogeneous substance use patterns emerged among Black American men and each pattern has distinct risk factors and outcomes in young adulthood. For prevention, more attention is needed for cannabis use patterns and psychosocial adversities that are unique to Black population.
Evaluating the clinical effectiveness and safety of insulin glargine 300 U/mL in individuals with type 2 diabetes uncontrolled on basal insulin: A real‐world evidence study from Saudi Arabia (EVOLUTION)
Authors: Al Malki Faisal , El Damanhoury Bandar , Othman Abdallah , Alghamdi Zain , AlQahtani Majed , Madgy Amr , Chouikrat Zahir 
Published: July 2023

AbstractAimTo evaluate the effectiveness and safety profile of switching to insulin glargine 300 U/mL (Gla‐U300) in patients with uncontrolled type 2 diabetes (T2D) on basal insulin in Saudi Arabia.Materials and MethodsWe conducted a multicentre retrospective study that retrieved the medical records of adult T2D patients switched to Gla‐U300 because of poor glycaemic control on their basal insulin. Data covering 6 months ± 30 days before and after the switch were retrieved.ResultsData from 718 patients were analysed. The mean HbA1c decreased significantly 6 months after switching to Gla‐U300, with a mean reduction of 0.7% (95% confidence interval [CI] 0.6%‐0.9%; P < .001). The percentage of patients with HbA1c levels of less than 7% increased from 6.4% before switching to 10.3% after switching to Gla‐U300. The percentage of patients achieving the predefined individualized HbA1c goal increased from 8.6% before switching to 17.3% after switching to Gla‐U300. The mean daily insulin dose decreased from a baseline level of 32.2 (± 14.7) to 31.0 (± 15) U (P = .09). About 36.1 of the patients required adjustment to the initial dose. Gla‐300 was well tolerated; 4.5% of the patients experienced overall confirmed or symptomatic hypoglycaemia, compared with 15.3% before switching to Gla‐U300. The incidence of severe hypoglycaemia after switching was 0.6% (n = 4 patients), compared with 1% before switching.ConclusionsReal‐world evidence supports the effectiveness of switching to Gla‐U300 from first‐generation basal insulin in T2D in Saudi Arabia.
Hyperacute Sapien Aortic Valve thrombosis in a patient with Antiphospholipid Syndrome (APS)
Authors: Pergolini Amedeo , Chianta Vania , Zampi Giordano , Pontillo Daniele , Diana Davide , Russo Marco , Cammardella Antonio , Musumeci Francesco 
Published: July 2023

AbstractIn this case we briefly describe the case of an old woman presenting with acute exertional dyspnea due to hyperacute Sapien Valve thrombosis.
Efficacy of isatuximab in combination with steroids for the treatment of relapsed/refractory multiple myeloma patients exhibiting only biochemical progression—A single center retrospective study
Authors: Regidor Bernard Sean , Jew Scott , Goldwater Marissa‐Skye , Beatty Bethany Marie , Bujarski Sean , ElSayed Adam , Danis Ryan , Kim Susanna , Swift Regina , Schwartz Gary , Berenson James R. 
Published: July 2023

AbstractObjectivesIsatuximab is approved for treatment of relapsed/refractory multiple myeloma (RRMM) with dexamethasone and carfilzomib or pomalidomide. Patients receiving these three‐drug regimens have exhibited more Grade ≥ 3 adverse events (AEs) compared to the two‐drug class combination of isatuximab and steroids alone. Thus, this single‐center retrospective study investigated the efficacy of isatuximab with dexamethasone and methylprednisolone (ISAdm) for RRMM patients showing only biochemical progression (BP) of their disease.MethodsTwenty‐four RRMM patients exhibiting only BP were administered isatuximab at 10 mg/kg with dexamethasone once weekly for cycle 1 of a 28‐day cycle, followed by every other week for each cycle thereafter. Starting in cycle 2, oral methylprednisolone was added every other day stopping 48 h before and starting 48 h after each dexamethasone infusion.ResultsOverall response rate and clinical benefit rate were 63% and 79%, respectively. Progression free survival was 12.9 months. There were only 5 AEs of Grade ≥ 3 which included lymphocytopenia (13%), leukopenia (4%), and neutropenia (4%). No Grade ≥ 3 AE related to respiratory infection, anemia, or thrombocytopenia were reported.ConclusionThis study shows that the two‐drug class combination of ISAdm is an effective and well tolerated treatment option for RRMM patients exhibiting only BP.
The associations between foreign language anxiety and the effectiveness of immediate and delayed corrective feedback
Authors: Fu Mengxia , Li Shaofeng 
Published: July 2023

AbstractThis article reports on a study exploring the associations between foreign language anxiety and the effectiveness of immediate and delayed corrective feedback (CF) in the acquisition of the English past tense. One hundred and two middle school English as a foreign language (EFL) learners responded to the Foreign Language Classroom Anxiety Scale for the purpose of gauging their foreign language anxiety. They were then assigned to three conditions: Immediate CF, Delayed CF, and Task Only. The three groups performed six communicative tasks in three treatment sessions, two in each session, which aimed to elicit the learners' use of the English past tense. The Immediate and Delayed CF groups received CF treatments during task performance in the first and final treatment sessions, respectively, and the Task Only group performed the learning tasks without receiving any CF treatment. The results showed that anxiety was a significant predictor of Delayed CF but not Immediate CF and Task Only. Drawing on attentional control theory, we interpret the results as suggesting that the debilitative impact of anxiety on L2 learning is triggered by a heavier processing burden delayed CF imposes on learners' cognitive resources.
Leveraging Sequence Stratigraphy to Accelerate Site Remediation: Pliocene Citronelle Formation, Eglin Air Force Base, Florida, USA
Authors: Shultz Mike , Plank Colin , Stapleton Mark , Giannetta Leo , Cramer Rick 
Published: July 2023

AbstractAt Eglin Air Force Base (AFB) in the Florida Panhandle, a groundwater extraction and treatment system was installed to contain and remediate a chlorinated solvent plume. After 2 years of operation, the system was not removing the contaminant mass at the rate predicted or required to meet performance‐based contract terms. As a result, a sequence‐stratigraphic analysis was initiated to develop a strategy to improve performance. Sequence Stratigraphy methods were employed to identify a marine flooding surface (mfs) formed during a relative sea level highstand. The analysis also found that the mfs was locally eroded away, indicating that incised valleys were eroded into the formation during a relative lowstand of sea level. These valleys were backfilled with coarse‐grained fluvial and estuarine strata. The analysis concluded that the groundwater extraction system lacked an extraction well screened within the coarse‐grained valley fill. An additional extraction well was installed, which targeted the incised valley fill and resulted in a significant increase in contaminant mass removal rate without increasing system capacity or operational costs. This case study suggests that efficiency improvements are tenable at many sites where groundwater remediation is occurring within the Surficial Aquifer System of the Gulf Coast (Citronelle Formation) as well as sites in similar geologic settings worldwide.
Hsa‐miR‐27b‐5p suppresses the osteogenic and odontogenic differentiation of stem cells from human exfoliated deciduous teeth via targeting BMPR1A: An ex vivo study
Authors: Guo Rong , Gu Tingjie , Xiao Ya , Xiao Tong , Liu Qian , Li Zehan , Yu Jinhua 
Published: July 2023

AbstractAimRecently, miR‐27b‐5p was shown to be abundantly expressed in extracellular vehicles (EVs) from the inflammatory microenvironment. This study determined the role of miR‐27b‐5p in regulating osteogenic and odontogenic differentiation of stem cells from human exfoliated deciduous teeth (SHEDs) and further examined the regulatory mechanism of bone morphogenetic protein receptor type‐1A (BMPR1A).MethodologyCharacteristics of SHEDs and SHEDs‐EVs derived from SHEDs were evaluated respectively. The expression of miR‐27b‐5p in SHEDs and EVs was detected during osteo‐induction. Mechanically, SHEDs were treated with miR‐27b‐5p mimics or an inhibitor, and the osteogenic/odontogenic differentiation and proliferation were assessed. Bioinformatic analysis and luciferase reporter were utilized for target gene prediction and verification. Finally, BMPR1A‐overexpressed plasmids were transfected into SHEDs to investigate the participation of the BMPR1A/SMAD4 pathway. Data were analysed using Student's t‐test, one‐way analysis of variance and Chi‐square test.ResultsMiR‐27b‐5p was expressed in both SHEDs and EVs and was significantly increased at the initial stage of differentiation and then decreased in a time‐dependent manner (p < .01). Upregulation of miR‐27b‐5p significantly suppressed osteogenic/odontogenic differentiation of SHEDs and inhibited proliferation (p < .05), whereas inhibition of miR‐27b‐5p enhanced the differentiation (p < .05). Dual‐luciferase reporter assay and pull‐down assay confirmed the binding site between miR‐27b‐5p and BMPR1A (p < .05). The overexpression of BMPR1A rescued the effect of miR‐27b‐5p, while contributed to the decrease of pluripotency (p < .05). Additionally, miR‐27b‐5p maintained pluripotency in BMPR1A‐overexpressed SHEDs (p < .05).ConclusionsMiR‐27b‐5p in SHEDs/EVs was inversely associated with differentiation and suppressed the osteogenic and odontogenic differentiation of SHEDs and maintained the pluripotency of SHEDs partly by shuttering BMPR1A‐targeting BMP signalling. Theoretically, inhibition of miR‐27b‐5p represents a potential strategy to promote osteanagenesis and dentinogenesis. However, miR‐27b‐5p capsuled EVs might maintain cell pluripotency and self‐renewal for non‐cell‐targeted therapy.
Registered nurses' psychological capital: A scoping review
Authors: Flinkman Mervi , Coco Kirsi , Rudman Ann , Leino‐Kilpi Helena 
Published: July 2023

AbstractAimsThe aim was to examine the extent and scope of empirical research concerning registered nurses' psychological capital.BackgroundIn a time of global nursing shortage, identifying variables that could positively contribute to the retention of the nursing workforce is essential. Prior research has shown that psychological capital correlates positively with employees' better performance and well‐being.DesignA scoping review.Data sourcesA systematic literature search was conducted in the following databases: PubMed, CINAHL, PsycINFO, Web of Science and Scopus covering the period from 1 January 2005 to 7 May 2023.Review methodsThe JBI methodological guidance for scoping reviews was followed. The results were summarized narratively.ResultsA total of 111 studies reported in 114 peer‐reviewed articles were included. Studies were carried out across 20 countries, with the majority from China (45), Australia (nine), Pakistan (nine), Canada (eight), South Korea (eight) and the United States (eight). A positive correlation was found between registered nurses' psychological capital and desirable work‐related outcomes, such as work engagement, commitment and retention intention.ConclusionA comprehensive overview of research evidence suggests that psychological capital is associated with many positive work‐related outcomes and might therefore be a valuable resource for reducing nurse turnover.
A concise review on the role of MIR100HG in human disorders
Authors: Ghafouri‐Fard Soudeh , Harsij Atefeh , Farahzadi Hossein , Hussen Bashdar Mahmud , Taheri Mohammad , Mokhtari Majid 
Published: July 2023

AbstractMIR100HG is a long non‐coding RNA (lncRNA) encoded by a locus on chr11:122,028,203‐122,556,721. This gene can regulate cell proliferation, apoptosis, cell cycle transition and cell differentiation. MIR100HG was firstly identified through a transcriptome analysis and found to regulate differentiation of human neural stem cells. It is functionally related with a number of signalling pathways such as TGF‐β, Wnt, Hippo and ERK/MAPK signalling pathways. Dysregulation of MIR100HG has been detected in a diversity of cancers in association with clinical outcomes. Moreover, it has a role in the pathophysiology of dilated cardiomyopathy, intervertebral disk degeneration and pulmonary fibrosis. The current study summarizes the role of these lncRNAs in human disorders.
Gone‐wild grapevines in forests may act as a potential habitat for ‘Flavescence dorée’ phytoplasma vectors and inoculum
Authors: Oggier Alan , Conedera Marco , Jermini Mauro , Debonneville Christophe , Schumpp Olivier , Rizzoli Attilio 
Published: July 2023

Abstract‘Flavescence dorée’ (FD) is a quarantine grapevine disease associated with FD phytoplasmas (FDp). In Switzerland, FD was first reported in 2004 in the southern part of the Canton Ticino, from where, within a few years, it spread to nearly the entire vineyard area of the Southern Alps, despite the mandatory control measures. The aim of this study was to assess the possible role of gone‐wild grapevines (GWGVs) in forests resulting from early abandoned vineyards as a habitat for the main FDp vector, Scaphoideus titanus, and for the best alternative vector candidate, Orientus ishidae, as well as an FDp inoculum reservoir in Southern Switzerland. Leaf samples were collected in 20 plots and tested for the presence of FDp. Moreover, fifteen of these plots were monitored with yellow sticky traps to determine the presence and infection status of insect vectors. Finally, a hatching experiment under controlled conditions was conducted to investigate the possible oviposition activity by FDp vectors, using wood collected from GWGVs present in 11 forest sites in the surroundings of cultivated vineyards. GWGVs in forests were confirmed to act as an FDp reservoir and to represent a suitable habitat for FDp vectors (in particular, for S. titanus). Abandoned vineyards should be included in the FD management strategy and their systematic rogueing should be applied as soon as possible and in particular before the transition from vineyard to forest occurs, in order to avoid the survival of S. titanus and the establishment of inoculum in uncontrolled landscape compartments.
Effectiveness of UAV‐based DTM and satellite‐based DEMs for local‐level flood modeling in Jamuna floodplain
Authors: Iqbal Ashik , Mondal M. Shahjahan , Veerbeek William , Khan M. Shah Alam , Hakvoort Hans 
Published: July 2023

AbstractOpen‐source, satellite‐based digital elevation models (DEMs) are widely used for flood modeling. However, studies on effectiveness of these DEMs in depicting local‐level flood processes are limited. This study generated a high‐resolution digital terrain model (DTM) based on unmanned aerial vehicle (UAV) photogrammetry and used in a two‐dimensional (2D) hydrodynamic model (HEC‐RAS) to simulate the flood processes in a floodplain environment of the Jamuna River in northern Bangladesh. The effectiveness of a few satellite‐based DEMs was also compared with this DTM by using the DEMs in the same hydrodynamic model. Field data for two flood seasons were collected to develop the model. The results indicate that the 2D model with UAV‐based DTM provides the flood parameters, such as flood arrival time, depth, duration and extent, better than those from the satellite‐based DEMs. Of the open‐source DEMs, the FABDEM and the WorldDEM™ have the least errors and provide better results compared to the SRTM30, ALOS PALSAR, and ASTER DEMs. The UAV technique with ground control points and field measurements for the tree‐canopy and water areas is very useful in generating a fit‐for‐purpose DTM. The findings of this study would be useful for terrain generation and DEM selection for local‐level flood modeling elsewhere.