bluuebunny/crossref_metadata_2025_split huggingface dataset:
Application of single-cell RNA sequencing analysis of novel breast cancer phenotypes based on the activation of ferroptosis-related genes
Authors: Liu Shuochuan , Zhao Yajie , Zhang Jiao , Liu Zhenzhen 
Published: May 2023

AbstractFerroptosis is distinct from classic apoptotic cell death characterized by the accumulation of reactive oxygen species (ROS) and lipid peroxides on the cell membrane. Increasing findings have demonstrated that ferroptosis plays an important role in cancer development, but the exploration of ferroptosis in breast cancer is limited. In our study, we aimed to establish a ferroptosis activation-related model based on the differentially expressed genes between a group exhibiting high ferroptosis activation and a group exhibiting low ferroptosis activation. By using machine learning to establish the model, we verified the accuracy and efficiency of our model in The Cancer Genome Atlas Breast Invasive Carcinoma (TCGA-BRCA) set and gene expression omnibus (GEO) dataset. Additionally, our research innovatively utilized single-cell RNA sequencing data to systematically reveal the microenvironment in the high and low FeAS groups, which demonstrated differences between the two groups from comprehensive aspects, including the activation condition of transcription factors, cell pseudotime features, cell communication, immune infiltration, chemotherapy efficiency, and potential drug resistance. In conclusion, different ferroptosis activation levels play a vital role in influencing the outcome of breast cancer patients and altering the tumor microenvironment in different molecular aspects. By analyzing differences in ferroptosis activation levels, our risk model is characterized by a good prognostic capacity in assessing the outcome of breast cancer patients, and the risk score can be used to prompt clinical treatment to prevent potential drug resistance. By identifying the different tumor microenvironment landscapes between the high- and low-risk groups, our risk model provides molecular insight into ferroptosis in breast cancer patients.
Japanese Society of Medical Oncology/Japan Society of Clinical Oncology/Japanese Society of Pediatric Hematology/Oncology-led clinical recommendations on the diagnosis and use of tropomyosin receptor kinase inhibitors in adult and pediatric patients with neurotrophic receptor tyrosine kinase fusion-positive advanced solid tumors
Authors: Naito Yoichi , Mishima Saori , Akagi Kiwamu , Hayashi Naomi , Hirasawa Akira , Hishiki Tomoro , Igarashi Ataru , Ikeda Masafumi , Kadowaki Shigenori , Kajiyama Hiroaki , Kato Motohiro , Kenmotsu Hirotsugu , Kodera Yasuhiro , Komine Keigo , Koyama Takafumi , Maeda Osamu , Miyachi Mitsuru , Nishihara Hiroshi , Nishiyama Hiroyuki , Ohga Shouichi , Okamoto Wataru , Oki Eiji , Ono Shigeru , Sanada Masashi , Sekine Ikuo , Takano Tadao , Tao Kayoko , Terashima Keita , Tsuchihara Katsuya , Yatabe Yasushi , Yoshino Takayuki , Baba Eishi 
Published: May 2023

Abstract
Background
Clinical trials have reported the efficacy of tropomyosin receptor kinase (TRK) inhibitors against neurotrophic receptor tyrosine kinase (NTRK) fusion gene-positive advanced solid tumors. The accumulated evidence of tumor-agnostic agent has made since TRK inhibitors were approved and used in clinical practice. Therefore, we have revised the ‘Japan Society of Clinical Oncology (JSCO)/Japanese Society of Medical Oncology (JSMO)-led clinical recommendations on the diagnosis and use of tropomyosin receptor kinase inhibitors in adult and pediatric patients with neurotrophic receptor tyrosine kinase fusion-positive advanced solid tumors, cooperated by the Japanese Society of Pediatric Hematology/Oncology (JSPHO)’.

Methods
Clinical questions regarding medical care were formulated for patients with NTRK fusion-positive advanced solid tumors. Relevant publications were searched by PubMed and Cochrane Database. Critical publications and conference reports were added manually. Systematic reviews were performed for each clinical question for the purpose of developing clinical recommendations. The committee members identified by JSCO, JSMO, and JSPHO voted to determine the level of each recommendation considering the strength of evidence, expected risks and benefits to patients, and other related factors. Thereafter, a peer review by experts nominated from JSCO, JSMO, and JSPHO, and the public comments among all societies' members was done.

Results
The current guideline describes 3 clinical questions and 14 recommendations for whom, when, and how NTRK fusion should be tested, and what is recommended for patients with NTRK fusion-positive advanced solid tumors.

Conclusion
The committee proposed 14 recommendations for performing NTRK testing properly to select patients who are likely to benefit from TRK inhibitors.
Comparison of proactive and conventional treatment of anastomotic leakage in rectal cancer surgery: a multicentre retrospective cohort series
Authors: Talboom K. , Greijdanus N. G. , Brinkman N. , Blok R. D. , Roodbeen S. X. , Ponsioen C. Y. , Tanis P. J. , Bemelman W. A. , Cunningham C. , de Lacy F. B. , Hompes Roel 
Published: May 2023

Abstract
Purpose
Comparative studies on efficacy of treatment strategies for anastomotic leakage (AL) after low anterior resection (LAR) are almost non-existent. This study aimed to compare different proactive and conservative treatment approaches for AL after LAR.

Methods
This retrospective cohort study included all patients with AL after LAR in three university hospitals. Different treatment approaches were compared, including a pairwise comparison of conventional treatment and endoscopic vacuum-assisted surgical closure (EVASC). Primary outcomes were healed and functional anastomosis rates at end of follow-up.

Results
Overall, 103 patients were included, of which 59 underwent conventional treatment and 23 EVASC. Median number of reinterventions was 1 after conventional treatment, compared to 7 after EVASC (p < 0.01). Median follow-up was 39 and 25 months, respectively. Healed anastomosis rate was 61% after conventional treatment, compared to 78% after EVASC (p = 0.139). Functional anastomosis rate was higher after EVASC, compared to conventional treatment (78% vs. 54%, p = 0.045). Early initiation of EVASC in the first week after primary surgery resulted in better functional anastomosis rate compared to later initiation (100% vs. 55%, p = 0.008).

Conclusion
Proactive treatment of AL consisting of EVASC resulted in improved healed and functional anastomosis rates for AL after LAR for rectal cancer, compared to conventional treatment. If EVASC was initiated within the first week after index surgery, a 100% functional anastomosis rate was achievable.
A cost-of-illness study of Behçet syndrome in Italy
Authors: Lorenzoni Valentina , Marinello Diana , Palla Ilaria , Mosca Marta , Turchetti Giuseppe , Talarico Rosaria 
Published: May 2023

Abstract
Objective
This study aims at evaluating the cost-of-illness (COI) of patients diagnosed with Behcet’s syndrome (BS) in Italy, trying to depict the impact of different costs’ components to the overall economic burden and analysing the variability of costs according to years since diagnosis and age at first symptoms.

Methods
With a cross-sectional evaluation, we surveyed a large sample of BS patients in Italy assessing several dimensions related to BS, also including fact related to the use of health resources utilization, formal and informal care, and productivity losses. Overall costs, direct health, direct non-health, and indirect costs were thus estimated per patient/year considering a Societal perspective and the impact of years since diagnosis, age at first symptoms on costs was evaluated using generalized linear model (GLM) and a two-part model, adjusting for age and distinguishing among employed and non-employed responders.

Results
A total of 207 patients were considered in the present study. From the perspective of the Society, mean overall costs for BS patient were estimated to be 21,624 € (0;193,617) per patient/year. Direct non-health expenses were the main costs component accounting for 58% of the overall costs, followed direct health costs, 36%, while indirect costs because of productivity losses represented 6% of the overall costs. Being employed resulted in significantly lower overall costs (p = 0.006). Results from the multivariate regression analyses suggested that the probability of incurring in overall costs equal to zero decreased as time from BS diagnosis is 1 year or more as compared to newly diagnosed patients (p < 0.001); while among those incurring in expenses, costs decreased for those experiencing first symptoms between 21 and 30 years (p = 0.027) or later (p = 0.032) as compared to those having symptoms earlier. Similar findings emerged among the subgroups of patients declaring themselves as workers, while no impact of years since diagnosis or age of first symptoms was found among non-workers.

Conclusions
The present study offers a comprehensive overview of the economic consequences imposed by BS in a societal perspective, providing insights into the distribution of the different costs component related to BS, thus helping the development of targeted policies.
Strong convergence of an adaptive time-stepping Milstein method for SDEs with monotone coefficients
Authors: Kelly Cónall , Lord Gabriel J. , Sun Fandi 
Published: May 2023

AbstractWe introduce an explicit adaptive Milstein method for stochastic differential equations with no commutativity condition. The drift and diffusion are separately locally Lipschitz and together satisfy a monotone condition. This method relies on a class of path-bounded time-stepping strategies which work by reducing the stepsize as solutions approach the boundary of a sphere, invoking a backstop method in the event that the timestep becomes too small. We prove that such schemes are strongly$$L_2$$L2convergent of order one. This order is inherited by an explicit adaptive Euler–Maruyama scheme in the additive noise case. Moreover we show that the probability of using the backstop method at any step can be made arbitrarily small. We compare our method to other fixed-step Milstein variants on a range of test problems.
Monte Carlo integration of $$C^r$$ functions with adaptive variance reduction: an asymptotic analysis
Authors: Plaskota Leszek , Przybyłowicz Paweł , Stȩpień Łukasz 
Published: May 2023

AbstractThe theme of the present paper is numerical integration of $$C^r$$

C
r

functions using randomized methods. We consider variance reduction methods that consist in two steps. First the initial interval is partitioned into subintervals and the integrand is approximated by a piecewise polynomial interpolant that is based on the obtained partition. Then a randomized approximation is applied on the difference of the integrand and its interpolant. The final approximation of the integral is the sum of both. The optimal convergence rate is already achieved by uniform (nonadaptive) partition plus the crude Monte Carlo; however, special adaptive techniques can substantially lower the asymptotic factor depending on the integrand. The improvement can be huge in comparison to the nonadaptive method, especially for functions with rapidly varying rth derivatives, which has serious implications for practical computations. In addition, the proposed adaptive methods are easily implementable and can be well used for automatic integration.
If the party is good, you can stay longer—effects of trait hedonic capacity on hedonic quantity and performance
Authors: Bernecker Katharina , Becker Daniela , Guobyte Aiste 
Published: May 2023

AbstractResearch suggests that people’s capacity to successfully pursue hedonic goals is at least as important for well-being as trait self-control. Extending this research, we tested whether trait hedonic capacity is related to more time spent with hedonic goal pursuit (i.e., hedonic quantity) and whether this explains its positive relationship with well-being. Second, we explored whether this may come at a cost for people’s performance. Results show that people with higher trait hedonic capacity do spend more time with hedonic goal pursuit (Study 1 and 2). However, hedonic quality not hedonic quantity accounts for its positive relationship with well-being. Further, people higher vs. lower in trait hedonic capacity perform equally well in their studies (Study 2) and their jobs (Study 3 and 4). Thus, trait hedonic capacity seems to allow people to invest more time into their hedonic goals in a way that does not jeopardize their academic and job performance.
Cardiometabolic risk in people under 40 years with severe mental illness: reading between the guidelines
Authors: Carolan Aoife , Hynes Caroline , McWilliams Stephen , Ryan Cristín , Strawbridge Judith , Keating Dolores 
Published: May 2023

AbstractPeople with severe mental illness (SMI) have a shorter life expectancy than the rest of the population. Multimorbidity and poorer physical health contribute to this health inequality. Cardiometabolic multimorbidity confers a significant mortality risk in this population. Multimorbidity is not restricted to older people and people with SMI present with multimorbidity earlier in life. Despite this, most screening, prevention and treatment strategies target older people. People under 40 years with SMI are underserved by current guidelines for cardiovascular risk assessment and reduction. Research is needed to develop and implement interventions to reduce cardiometabolic risk in this population.
Purinergic P2X3 receptors in the carotid body as new therapeutic targets for controlling heart failure
Authors: He Ximeng , Zhou Zhichao 
Published: May 2023

Abstract
Heart failure is associated with multiple mechanisms, including sympatho-excitation, and is one of the leading causes of death worldwide. Enhanced carotid body chemoreflex function is strongly related to excessive sympathetic nerve activity and sleep-disordered breathing in heart failure. How to reduce the excitability of the carotid body is still scientifically challenging. Both clinical and experimental evidence have suggested that targeting purinergic receptors is of great potential to combat heart failure. In a recent study, Lataro et al. (Lataro et al. in Nat Commun 14:1725, 5) demonstrated that targeting purinergic P2X3 receptors in the carotid body attenuates the progression of heart failure. Using a series of molecular, biochemical, and functional assays, the authors observed that the carotid body generates spontaneous, episodic burst discharges coincident with the onset of disordered breathing in male rats with heart failure, which was generated by ligating the left anterior descending coronary artery. Moreover, P2X3 receptor expression was found to be upregulated in the petrosal ganglion chemoreceptive neurons of rats with heart failure. Of particular note, treatment with a P2X3 antagonist rescued pathological breathing disturbances, abolished episodic discharges, reinstated autonomic balance, attenuated cardiac dysfunction, and reduced the immune cell response and plasma cytokine levels in those rats.
Diagnosis and management of osteoporosis in Saudi Arabia: 2023 key updates from the Saudi Osteoporosis Society
Authors: Al-Saleh Yousef , Sulimani Riad , Sabico Shaun , Alshahrani Fahad M. , Fouda Mona A. , Almohaya Mohammed , Alaidarous Salwa B. , Alkhawashki Hazem M. , Alshaker Mohammed , Alrayes Hanan , Saleh Najla , Al-Daghri Nasser M. 
Published: May 2023

Abstract

Summary

The Saudi Osteoporosis Society (SOS) has updated its guidelines for the diagnosis and management of osteoporosis in Saudi Arabia (SA), with emphasis on postmenopausal women. This document is relevant to all healthcare professionals in SA involved in the care of patients with osteoporosis and osteoporosis-related fractures.

Introduction
The SOS launched the first national osteoporosis guidelines in 2015 and spearheaded the Gulf Cooperation Council Countries (GCC) osteoporosis consensus report in 2020 which was under the auspices of the European Society for Clinical and Economic Aspects of Osteoporosis (ESCEO). This paper highlights a major update of the guidelines in the SA setting.

Methods
This guideline is an adaptation of the current guidelines derived from ESCEO, the American Association of Clinical Endocrinologists (AACE), and the GCC osteoporosis consensus report and studies on osteoporosis done in SA. Where accessible, the timeliest systematic review, meta-analysis, and randomized controlled trials were used as evidence.

Results
The present update includes new recommendations for the assessment of osteoporosis taking into consideration the Saudi model of FRAX for fracture probabilities, appropriate doses for the maintenance of vitamin D status and calcium, the use of representative blood analytes for therapy monitoring, the use of romosozumab and sequential therapy in the pharmacological management strategies, and the establishment of fracture liaison services to prevent secondary fractures.

Conclusion
This updated guideline is for all healthcare professionals involved in osteoporosis and post-fracture care and management in SA and harmonized the most up-to-date changes in the field based on evidence-based medicine for use in the local setting.
Relationship between leptin and white blood cells: a potential role in infection susceptibility and severity—the Olivetti Heart Study
Authors: D’Elia Lanfranco , Masulli Maria , Iacone Roberto , Russo Ornella , Strazzullo Pasquale , Galletti Ferruccio 
Published: May 2023

AbstractA number of evidence showed an emerging role of leptin on immune system, involving inflammation, and innate and adaptive immunity. Few observational studies have evaluated the relationship between leptin and immunity, albeit with low statistical power and methodological differences. Therefore, the aim of this study was to evaluate the potential role of leptin on the immunity, expressed as white blood cells (WBC)—and its subpopulations, by comprehensive multivariate models in a sample of adult men. A cross-sectional evaluation of a general population comprised 939 subjects participating in the Olivetti Heart Study, with available leptin levels and WBC—and its subpopulations. WBC were significantly and positively associated with leptin, C-reactive protein and HOMA index (p < 0.05), but not with age and anthropometric indices (p > 0.05). The multivariate analysis confirmed the association between leptin and WBC, after accounting for main confounders (p < 0.05). Additional analysis on WBC subpopulations showed a positive and significant correlation between leptin and lymphocytes, monocytes and eosinophils (p < 0.05), but not with neutrophils and basophils (p > 0.05). After stratification by body weight, the positive and significant association between leptin and WBC—and its subpopulations—was found in excess body weight participants. The results of this study indicate a direct relationship between leptin levels and WBC—and its subpopulations—in excess body weight participants. These results support the hypothesis that leptin has modulatory functions on immunity and role in the pathophysiology of immune-related diseases, in particular in those associated with excess body weight.
Temporal trends of particle gross β-activity and PM2.5 mass concentrations in the USA during 2001–2017
Authors: Matthaios Vasileios N. , Wolfson Jack M. , Li Longxiang , Lawrence Joy , Koutrakis Petros 
Published: May 2023

AbstractRecent studies conducted in the USA have shown that adverse health effects of fine particulate matter (PM2.5) persist at levels below the national air quality standards. More recently, particle radioactivity has also been associated with adverse health effects. However, the importance of particle radioactivity at low PM2.5 levels has not been thoroughly explored. The present paper investigates the temporal trends and the relationship of particle gross β-activity (PM-β) and PM2.5 mass in the 48 states of the contiguous USA during the period of 2001–2017. With the implementation of stringent air pollution control policies, national ambient PM2.5 concentrations decreased by 38.5% during this period. However, a smaller decrease of 9.4% was observed for PM-β, while the mean PM-β/PM2.5 ratio increased by 49.1%. PM-β is mostly associated with radon emissions and its progeny, which do not change much with time. The largest PM2.5 and PM-β reductions were observed in the Southeast, while the smallest were found in the West. When the aggregated PM-β to PM2.5 ratio is stratified by PM2.5 levels, the ratio was found to be highest when PM2.5 is <3 μg/m3, with a median PM-β to PM2.5 ratio of 0.77 (0.64–0.88; 25th–75th percentiles). Overall, when not stratified by PM2.5 levels, the greatest state-wide overall PM-β /PM2.5 ratios were found in Wyoming (0.69) and South Dakota (0.51), areas with higher radon, while the lowest (0.17) were in Delaware followed by New Jersey (0.18). These results indicate that the ratio of ambient particle radioactivity to particle mass concentration typically is higher at low PM2.5 levels, and consequently, the toxicity per unit mass is expected to be higher.
Alexithymia and Hypertension: Does Personality Matter? A Systematic Review and Meta-analysis
Authors: Di Tella Marialaura , Benfante Agata , Airale Lorenzo , Castelli Lorys , Milan Alberto 
Published: May 2023

Abstract
Purpose of review
Personality characteristics, such as alexithymia, may lead to alterations in the autonomic nervous system functionality, predisposing individuals to an increased risk of hypertension (HTN). The present meta-analysis aimed to quantify the presence of alexithymia in people with HTN and to assess for potential sources of heterogeneity between studies. PubMed, PsycINFO and Scopus databases were systematically searched, using the following strings: (“alexithymia” OR “alexithymic”) AND (“hypertension” OR “hypertensive”). Data were meta-analyzed with random-effects models.

Recent findings
A total of 13 studies met the inclusion criteria. The prevalence of alexithymia in people with and without HTN were obtained from 5 studies (26.3% vs 15.0%; pooling of odd ratios, 3.15 [95% CI, 1.14;8.74]), whereas the mean level of alexithymia between people with and without HTN was obtained from 7 studies Hedges g, 1.39 [95% CI, -0.39;3.16]). There was a significant association between alexithymia prevalence and year of article publication (ĝ = -0.04; 95% CI, -0.07;-0.01), whereas no significant relationship was detected between the former and both sex and age.

Summary
Findings revealed a greater prevalence of alexithymia in people with HTN than in participants without HTN. These findings suggest that alexithymia may contribute to both the onset and persistence of HTN symptomatology. However, future research is needed to clarify this association.