bluuebunny/crossref_metadata_2025_split huggingface dataset:
Meaningful Improvement and Worsening in Patients Who Do Not Achieve Low Disease Activity and Switch Therapy to a New Biologic or Targeted Disease-Modifying Antirheumatic Drug
Authors: Curtis Jeffrey R. , Fiore Stefano , Ford Kerri , Janak Jud C. , Chang Hong , Pappas Dimitrios A. , Blachley Taylor , Emeanuru Kelechi , Bykerk Vivian P. 
Published: March 2023

Objective
The aim of this study was to assess the change in disease activity associated with switching from 1 biologic/targeted synthetic disease-modifying antirheumatic drug (b/tsDMARD) to another in patients with rheumatoid arthritis who did not achieve low disease activity (LDA) after 6 to 12 months of their initial treatment.

Methods
This observational study included patients from the CorEvitas Rheumatoid Arthritis Registry, who initiated a b/tsDMARD at the index visit (prebaseline), had any clinical disease activity index (CDAI) improvement but did not achieve LDA/remission at the subsequent visit (baseline), and switched therapy at baseline or between baseline and follow-up visits. Regardless of the preswitch CDAI value, 2 thresholds of CDAI change were used to define meaningful improvement and worsening for all patients: ≥6 units and ≥12 units; no meaningful change was defined as any change between −6 to +6 units and −12 to +12 units, based on respective thresholds.

Results
Of 1226 patients fulfilling the inclusion criteria, 93 (7.6%) switched therapy at baseline or between baseline and follow-up, after an inadequate response at the baseline visit. At follow-up, meaningful worsening occurred in 30.1% and 12.9% of switchers, whereas the remaining switchers achieved meaningful improvement (34.4% and 20.4%) or had no meaningful change (35.5% and 66.7%), based on the thresholds of ≥6 and ≥12 units, respectively.

Conclusions
Rheumatoid arthritis patients, who had not achieved LDA and switched b/tsDMARD, were more likely to have meaningful improvement or no change, rather than meaningful worsening. These data may help some patients overcome their hesitancy to switch therapy, potentially improving clinical outcomes.
Prolonged COVID-19 PCR positivity and molnupravir treatment experience in a late-stage AIDS case with Kaposi sarcoma
Authors: Sarlak Konya Petek , Demirtürk Neşe 
Published: March 2023

In this case report, we describe the treatment of a young patient with end-stage AIDS, disseminated kaposi sarcoma and COVID-19 infection with molnupravir. With a positive SARS-CoV-2 test, a woman who had never received antiretroviral therapy was admitted to our hospital. On physical examination, multiple small purple maculopapular lesions were present on the body. In the laboratory findings HIV RNA was 255.000 copies, CD4:7 u/L. Tenofovir+ emtricitabine/dolutegravir was started for HIV treatment. Skin biopsy was found to be compatible with Kaposi's sarcoma. The patient's swab every other day was examined for COVID-PCR and remained positive for 63 days. Due to the necessity of oncological treatment, antiviral molnupiravir 2*800 mg treatment was started for 5 days. COVID-PCR performed 4 days after molnupravir treatment and it was negative. We think that early initiation of antiviral treatment is important for PCR negativity and early access to oncological treatment especially in end-stage COVID-positive AIDS cases.
Does social banking matter in times of crisis? Evidence from the COVID-19 pandemic: a combined SEM-neural network approach
Authors: Thongsri Nattaporn , Tripak Orawan 
Published: March 2023

PurposeThe purpose of this study was to investigate the factors that would influence the intention to use social banking during the coronavirus disease 2019 (COVID-19) pandemic. This study integrated two theories, namely the integrated technology acceptance model (TAM), which focused on the acceptance of technology by consumers, and electronic word of mouth (eWOM), which focused on consumer behavior. This study also applied the significant variables in the context of Thailand, which were trust and perceived risk.Design/methodology/approachA quantitative research method was applied by collecting data from 411 consumers during the COVID-19 pandemic in Thailand. A combined multi-analytic approach of a structural equation model (SEM)-neural network was used to analyze the data. In the first step, the SEM was used to determine the important factors that affected the adoption of social banking. In the second step, a neural network model was used to prioritize the important factors to confirm the results of the SEM method in step 1.FindingsThe empirical results of the data analysis using the SEM method showed that the perceived ease of use, perceived usefulness and trust were the most significant determinants of adopting social banking. This was consistent with the neural network method of the important factors.Practical implicationsThe results of this research could initiate issues that should be developed for the continued use of online banking among consumers in the context of developing countries, such as Thailand.Originality/valueThis research model provided guidelines for the effective development of mobile banking applications for use on mobile devices. The results of this research made strong theoretical contributions to the existing literature on online banking and offered procedures and information to the relevant sectors.Peer reviewThe peer review history for this article is available at: https://publons.com/publon/10.1108/IJSE-10-2022-0709
Impact of restructuring resources and services and their utilization in IIT Roorkee library, India
Authors: Kumar Rajender , Gupta Dinesh K. 
Published: March 2023

PurposeThis paper examines the impact of restructuring on the usage of resources and services in the Indian Institute of Technology library, Roorkee. Library users were approached to know their preferences between an electronic and traditional resources and services. Additionally, the study focused to know the extent of change in users' awareness, dependency, usage, frequency and satisfaction from library resources and services after restructuring these due to the availability of abundance of e-resources.Design/methodology/approachThe study adopted survey-based research design, for which a questionnaire was used as the principal instrument for data collection. This questionnaire was distributed to the library users when they physically visited the library. Notably, all the questionnaires distributed were returned, yielding thereby a cent percent response rate. One questionnaire was administrative on the librarian for getting the data regarding the changes made in the subscription of e-resources and services. The collected data were further analyzed with appropriate statistical techniques of Statistical Package for Social Sciences (SPSS) as chi-square test, mean and standard deviation.FindingsThe results showed that the use of both restructured resources and services had increased, and was found to be helpful for users. Also, the users' dependency on library had increased, showing thereby an upward trend for usage in the future. However, although the users’ awareness, usage and frequency of e-resources and ICT-based services have positively changed, and partially been satisfied, the study suggests that further revision is needed for further strengthening e-resources and services as per user's needs satisfaction.Practical implicationsThis study would create interest in rethinking library resources and services among librarians that tend to respond positively to user satisfaction and library functions; it also provides a strategic position of a library per se for its users in the future. Importantly, the assessment of the usage of restructuring resources and services, vis-a-vis their impact on users, may also serve as a key tool, which possibly could be applied to both public libraries and other types of higher education libraries.Originality/valueMany libraries find it difficult to balance between electronic and printed materials, especially in the fields of science and technology, due to the preferences of the users. Thus far, there have not been too many studies that have looked to assess restructuring of library resources and services, vis-a-vis their impact on library users. Therefore, the results of this study would provide a clear understanding to the library profession as to how users use e-resources and services in the digital age, and how much they are actually influenced by these.
Regulation of autophagy by circular RNAs in rheumatoid arthritis: Potential targets of action
Authors: Hu Yuedi , Liu Jian , Jiang Hui , Wan Lei , Qi Yajun , Zhou Qiao , Fang Yanyan , Sun Yanqiu 
Published: March 2023

AbstractPrevious studies have shown that autophagic pathogenesis of rheumatoid arthritis (RA) is regulated by circular RNAs (circRNAs), which accelerate bone damage by participating in the immune inflammatory response. Therefore, exploring the mechanisms underlying circRNA regulation of autophagy is essential for maintaining homeostasis of the skeletal microenvironment in RA and may improve our understanding of the specific pathways involved in the development of therapeutics. In this review, we discuss autophagic imbalance in RA and the regulatory mechanisms of circRNAs. We also explore possible targets for circRNA regulation of autophagy in RA, which may provide us with improved knowledge regarding the pathogenesis of RA.
Analysis of Readiness for enhanced health literacy in patients with type 2 diabetes mellitus
Authors: de Almeida Jocelha Maria Costa , Serra Eliana Brugin , Pascoal Livia Maia , Neto Marcelino Santos , Moreira Rafaella Pessoa , Palmeira Rolim Isaura Letícia Tavares 
Published: March 2023

AbstractPurposeTo estimate the prevalence of Readiness for enhanced health literacy in patients with type 2 diabetes mellitus through the diagnostic accuracy of the defining characteristics.MethodsA diagnostic accuracy study on the diagnosis of Readiness for enhanced health literacy in patients with type 2 diabetes mellitus was conducted using the latent class analysis model. The sample comprised 180 individuals attending a referral outpatient clinic in Maranhão, Brazil. The data analysis was conducted in the R Core Team software.FindingsThe prevalence of the nursing diagnosis was 55.23%. The main defining characteristics were expresses desire to enhance health communication with healthcare providers and expresses desire to enhance the understanding of health information to make healthcare choices. All defining characteristics showed significant specificity values.ConclusionsAccurate diagnoses contribute to individualized care plans for patients.Implications for nursing practiceThe diagnosis Readiness for enhanced health literacy should be considered in implementing care plans, including interventions to reduce complications in the health status of patients with type 2 diabetes mellitus.
Review article: Practical considerations for fluid resuscitation in cirrhosis
Authors: Claudel Sophie E. , Jaganathan Jeeva , Patel Ankit , Tapper Elliot B. , Verma Ashish 
Published: March 2023

SummaryBackgroundStandard clinical methods of assessing volume and providing resuscitation are not always applicable to patients with advanced or decompensated cirrhosis. Despite this being well known from a clinical perspective, there remains relatively little evidence to guide clinicians though fluid management in patients with cirrhosis and, often, multi‐organ system dysfunction.AimsThis review summarises the current understanding of the circulatory dysfunction in cirrhosis, modalities for assessing volume status, and considerations for fluid selection. It additionally provides a practical approach to fluid resuscitation.MethodsWe review current literature on cirrhosis pathophysiology in steady‐state and shock, clinical implications of fluid resuscitation, and strategies to assess intravascular volume. Literature reviewed here was identified by the authors through PubMed search and review of selected papers' references.ResultsClinical management of resuscitation in advanced cirrhosis remains relatively stagnant. Although several trials have attempted to establish the superior resuscitative fluid, the lack of improvement in hard clinical outcomes leaves clinicians without clear guidance.ConclusionsThe absence of consistent evidence for fluid resuscitation in patients with cirrhosis limits our ability to produce a clearly evidence‐based protocol for fluid resuscitation in cirrhosis. However, we propose a preliminary practical guide to managing fluid resuscitation in patients with decompensated cirrhosis. Further studies are needed to develop and validate volume assessment tools in the specific context of cirrhosis, while randomised clinical trials of protocolized resuscitation may improve care of this patient population.
Luminescence dating of anthropogenic deposits from Tall Zarʿa in the Jordan Valley
Authors: al Khasawneh Sahar , Schmidt Katharina , Murray Andrew , Thompson Warren 
Published: March 2023

AbstractThis study uses quartz‐based optically stimulated luminescence dating to determine when a massive fortification wall (W11186) was constructed in the archaeological site of Tall Zarʿa in the Jordan Valley. A total of 11 samples of sediments were taken from a trench on the north side of the wall (extramuros). The extracted quartz grains had good luminescence characteristics and were identified as well bleached by comparison with feldspar infrared‐stimulated luminescence (IRSL) ages. The optical ages showed that the deposition against the wall occurred in two different periods. The first was around 3.20 ± 0.07 ka ago (Iron Age), and the second was around 2.28 ± 0.08 ka (Hellenistic period). Human activity was evident because of the intermixing of cultural material with the presumed naturally deposited units.
Optimal dosing of gliclazide—A model‐based approach
Authors: Mim Sabiha R. , Hussein Haneen , Vidadi Samira , Leisegang Rory , Karamchand Sumanth , Rambiritch Virendra , Cotton Mark F. , Naidoo Poobalan , Kjellsson Maria C. 
Published: March 2023

AbstractGliclazide was approved as a treatment for type 2 diabetes in an era before model‐based drug development, and consequently, the recommended doses were not optimised with modern methods. To investigate various dosing regimens of gliclazide, we used publicly available data to characterise the dose‐response relationship using pharmacometric models. A literature search identified 21 published gliclazide pharmacokinetic (PK) studies with full profiles. These were digitised, and a PK model was developed for immediate‐ (IR) and modified‐release (MR) formulations. Data from a gliclazide dose‐ranging study of postprandial glucose were used to characterise the concentration–response relationship using the integrated glucose–insulin model. Simulations from the full model showed that the maximum effect was 44% of the patients achieving HbA1c <7%, with 11% experiencing glucose <3 mmol/L and the most sensitive patients (i.e., 5% most extreme) experiencing 35 min of hypoglycaemia. Simulations revealed that the recommended IR dose (320 mg) was appropriate with no efficacy gain with increased dose. However, the recommended dose for the MR formulation may be increased to 270 mg, with more patients achieving HbA1c goals (i.e., HbA1c <7%) without a hypoglycaemic risk higher than the resulting risk from the recommended IR dose.
Situation‐specific outcomes (Home Situations Questionnaire) in a randomized controlled trial of individual versus group parent training for children with Hyperkinetic Disorder/Attention‐deficit Hyperactivity Disorder
Authors: Heubeck Bernd G. , Welvaert Marijke , Richardson Alice 
Published: March 2023

AbstractObjectivesAssess (a) the variability of behaviour problems in children with Hyperkinetic Disorder/Attention‐DeficitHyperactivity Disorder (HKD/ADHD) across a range of family situations and (b) the degree to which behaviour in each situation can be modified through a cognitive behavioural parent training (CBPT). Furthermore (c), compare the effectiveness of training in two different formats and (d) test the proposition that group treatment benefits behaviour in a wider range of situations than individual treatment.MethodA registered multicentre randomized controlled trial comparing individual and group parent training to treatment‐as‐usual (TAU) for N = 237 children with HKD/ADHD. A German version of the Home Situations Questionnaire (HSQ) was employed to examine behaviour problems across a range of family situations, treatment‐related changes post‐treatment and at 6‐month follow‐up, while controlling for medication status.ResultsParents reported considerable variance in severity of behaviour problems across situations. All groups improved with time, but individual and group CBPT led to significantly greater improvement than TAU in many family situations. Results present situation‐specific treatment trajectories and demonstrate somewhat greater impact of individual compared with group training in certain situations post‐training and 6 months later.ConclusionsCBPT clearly adds to TAU (with effect sizes in the small to moderate range depending on situation). Individual was somewhat more successful than group format (which did not succeed in a wider range of situations). HSQ situations reveal a differentiated picture of child behaviour and treatment results. Situation‐specific assessment with an instrument like the HSQ offers promising perspectives that invite further development.
Long‐term cyanobacterial dynamics from lake sediment DNA in relation to experimental eutrophication, acidification and climate change
Authors: Mejbel Hebah S. , Irwin Courtney L. , Dodsworth William , Higgins Scott N. , Paterson Michael J. , Pick Frances R. 
Published: March 2023

Abstract

Cyanobacterial blooms in aquatic environments have impacted ecosystem health, altered food webs and contributed to substantial regional economic losses. The relative impacts of climate change, eutrophication and other environmental stressors on the formation of cyanobacterial blooms remain unclear as a consequence of the lack of long‐term data. The analysis of lake sediment archives can help address such questions.

The abundance of target cyanobacterial genes was quantified using droplet digital PCR from two experimental and two reference lakes at the IISD ‐ Experimental Lakes Area, Northwestern Ontario, Canada where various anthropogenic drivers have been manipulated and phytoplankton biomass and taxonomy (via microscopy) tracked over the past 50 years.

Based on sediment DNA (sedDNA) records, Lake 227 has seen more than two full orders of magnitude rise in cyanobacterial abundance in response to experimental nutrient (nitrogen and phosphorus) loading since 1969. Lake 223 also experienced a small increase in cyanobacterial abundance during a period of experimental acidification. The sedDNA archives also identified an increase in abundance of mcyE, a gene involved in microcystin synthesis, in Lake 227 after 1990 when experimental nitrogen loading ceased and only phosphorus loading continued. Sequencing of the cyanobacterial 16S rRNA gene from sedDNA revealed a shift towards Nostocales dominance in response to eutrophication in Lake 227; this was also seen in the more recent sediments of the other lakes but to a much lesser extent.

When comparing the sedDNA data with historical phytoplankton records of the past ~50 years, moderate‐to‐strong correlations were found between the two. This research validated the use of sedDNA for the analysis of long‐term trends in lakes and the results revealed additional changes that were not recorded from the surface‐water records.

Experimental nutrient loading had the greatest influence on the cyanobacterial community in Lake 227. However, climate change, via declines in heating degree days, was also significant in explaining variation in the cyanobacterial communities in the experimental lakes as well as the reference lakes.
Forest disturbance and recovery in Peruvian Amazonia
Authors: Requena Suarez Daniela , Rozendaal Danaë M. A. , De Sy Veronique , Decuyper Mathieu , Málaga Natalia , Durán Montesinos Patricia , Arana Olivos Alexs , De la Cruz Paiva Ricardo , Martius Christopher , Herold Martin 
Published: March 2023

AbstractAmazonian forests function as biomass and biodiversity reservoirs, contributing to climate change mitigation. While they continuously experience disturbance, the effect that disturbances have on biomass and biodiversity over time has not yet been assessed at a large scale. Here, we evaluate the degree of recent forest disturbance in Peruvian Amazonia and the effects that disturbance, environmental conditions and human use have on biomass and biodiversity in disturbed forests. We integrate tree‐level data on aboveground biomass (AGB) and species richness from 1840 forest plots from Peru's National Forest Inventory with remotely sensed monitoring of forest change dynamics, based on disturbances detected from Landsat‐derived Normalized Difference Moisture Index time series. Our results show a clear negative effect of disturbance intensity tree species richness. This effect was also observed on AGB and species richness recovery values towards undisturbed levels, as well as on the recovery of species composition towards undisturbed levels. Time since disturbance had a larger effect on AGB than on species richness. While time since disturbance has a positive effect on AGB, unexpectedly we found a small negative effect of time since disturbance on species richness. We estimate that roughly 15% of Peruvian Amazonian forests have experienced disturbance at least once since 1984, and that, following disturbance, have been increasing in AGB at a rate of 4.7 Mg ha−1 year−1 during the first 20 years. Furthermore, the positive effect of surrounding forest cover was evident for both AGB and its recovery towards undisturbed levels, as well as for species richness. There was a negative effect of forest accessibility on the recovery of species composition towards undisturbed levels. Moving forward, we recommend that forest‐based climate change mitigation endeavours consider forest disturbance through the integration of forest inventory data with remote sensing methods.