bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Protective Effects of Annexin A1 in Acute Lung Injury Mediated by Nrf2
Authors: Huang Hui , Shi Yuqin , Zhou Yuequan 
Published: January 2025

ABSTRACTBackgroundAcute lung injury (ALI), one of the most severe respiratory system diseases, is prevalent worldwide. Annexin A1 (AnxA1) is an important member of the annexin superfamily, known for its wide range of physiological functions. However, its potential protective effect against lipopolysaccharide (LPS)‐induced ALI remains unclear.Materials and MethodsMice were divided into four groups: Sham, LPS + vehicle, LPS + 0.1 μg AnxA1, and LPS + 0.5 μg AnxA1. Lung injury was assessed through histopathology, pulmonary wet‐to‐dry (W/D) ratio, cell counting of bronchoalveolar lavage fluid (BALF), oxidative stress analysis, and noninvasive pulmonary function testing. Gene and protein expression levels were measured using RT‐PCR, ELISA, and western blot analysis.ResultsAnxA1 alleviated LPS‐induced ALI by protecting lung tissue from damage, reducing the lung wet/dry (W/D) weight ratio, and improving LPS‐induced impaired lung function. Interestingly, administration of AnxA1 was found to repress the infiltration of inflammatory cells by decreasing the total cell count, neutrophils, and protein concentrations in bronchoalveolar lavage fluid (BALF). AnxA1 mitigated the inflammatory response in the pulmonary tissue by lowering the levels of IL‐1β, IL‐6, and TNF‐α in BALF of ALI mice. Additionally, AnxA1 attenuated oxidative stress in lung tissues of ALI mice by restoring the activity of catalase (CAT), SOD, and glutathione (GSH) but reducing the levels of malondialdehyde (MDA). We also found that AnxA1 suppressed activation of the NLRP3 signaling pathway. Mechanistically, AnxA1 activated the Nrf2/HO‐1 signaling pathway while preventing the activation of NF‐κB.ConclusionCollectively, these findings suggest that AnxA1 alleviates LPS‐induced ALI and might be a promising novel therapeutic agent against LPS‐induced ALI.
Regulatory T Cell Phenotype Related to Cytokine Expression Patterns in Post‐COVID‐19 Pulmonary Fibrosis and Idiopathic Pulmonary Fibrosis
Authors: Gangi Sara , Bergantini Laura , Paggi Irene , Spalletti Marco , Cameli Paolo , Bargagli Elena , d'Alessandro Miriana 
Published: January 2025

ABSTRACTBackgroundPost‐coronavirus disease 19 lung fibrosis (PCLF) shares common immunological abnormalities with idiopathic pulmonary fibrosis (IPF), characterized by an unbalanced cytokine profile being associated with the development of lung fibrosis. The aim of the present study was to analyze and compare the different subsets of CD4‐ and CD8‐T cells, along with specific cytokine expression patterns, in peripheral blood (PB) from patients affected by PCLF and IPF and healthy controls (HCs).MethodsOne‐hundred patients followed at the Rare Lung Disease Center of Siena University Hospital were enrolled. Eight HCs were recruited. PB samples were collected, and CD4‐ and CD8‐T subsets were analyzed through flow cytometry. Multiplex bead‐based LEGENDplex™ were used for cytokine quantification.ResultsHigher CD8 percentages were observed in IPF than in HCs and PCLF (p = 0.020 and p = 0.007, respectively). PCLF subgroup showed higher Th‐naïve, Th‐effector, Tc‐naïve, and Tc‐reg percentages than IPF (p < 0.001; p = 0.018; p = 0.005; p = 0.017, respectively). Th‐naïve and Tc‐naïve inversely correlated with Tc‐reg (p < 0.0001, r = −0.61 and p = 0.005, r = −0.39, respectively). Tc‐naïve‐PD1 and Tc‐effector‐PD1 percentages were higher in PCLF than IPF (p < 0.001), while Tfh‐reg and Tfc‐reg were significantly higher in IPF than PCLF (p < 0.001). IL‐4, IL‐2, TNF‐α, and IL‐17A were more expressed in PCLF than IPF (p < 0.001). IL‐8 directly correlated with Tc‐naïve percentages in PCLF (p = 0.018, r = 0.35).ConclusionA variety of immune cells is involved in the development and progression of pulmonary fibrosis confirming an immunological similarity between IPF and PCLF. T‐reg cells play a key role in the worsening of the disease. High cytokine values showed a pro‐fibrotic environment in PCLF patients, suggesting dysregulation of the immune system of these patients. Moreover, the immunological similarity between IPF and PCLF patients suggests that SARS‐CoV2 infection may trigger the activation of biological pathways common with IPF.
Advanced carbon as emerging energy materials in lithium batteries: A theoretical perspective
Authors: Yu Legeng , Chen Xiang , Yao Nan , Gao Yu‐Chen , Yuan Yu‐Hang , Gao Yan‐Bin , Tang Cheng , Zhang Qiang 
Published: January 2025

AbstractLithium batteries are becoming increasingly vital thanks to electric vehicles and large‐scale energy storage. Carbon materials have been applied in battery cathode, anode, electrolyte, and separator to enhance the electrochemical performance of rechargeable lithium batteries. Their functions cover lithium storage, electrochemical catalysis, electrode protection, charge conduction, and so on. To rationally implement carbon materials, their properties and interactions with other battery materials have been probed by theoretical models, namely density functional theory and molecular dynamics. This review summarizes the use of theoretical models to guide the employment of carbon materials in advanced lithium batteries, providing critical information difficult or impossible to obtain from experiments, including lithiophilicity, energy barriers, coordination structures, and species distribution at interfaces. Carbon materials under discussion include zero‐dimensional fullerenes and capsules, one‐dimensional nanotubes and nanoribbons, two‐dimensional graphene, and three‐dimensional graphite and amorphous carbon, as well as their derivatives. Their electronic conductivities are explored, followed by applications in cathode and anode performance. While the role of theoretical models is emphasized, experimental data are also touched upon to clarify background information and show the effectiveness of strategies. Evidently, carbon materials prove promising in achieving superior energy density, rate performance, and cycle life, especially when informed by theoretical endeavors.image
AI‐Driven Big Data Analytics for Mobile Healthcare
Authors: Parameshachari B. D. , Pelusi Danilo , Goswami Bhargavi 
Published: January 2025

ABSTRACTThis special issue highlights the key insights into the emerging trends and challenges of artificial intelligence (AI) driven big data analytics in mobile healthcare. The selected twenty‐six articles, which include two letters, explore innovative applications and advancements in AI‐driven healthcare technologies. The contributions of selected articles are divided into four main themes: Medical technology in healthcare communication and AI‐driven healthcare, Fitness and Sports in Health Technology, Mental Health based on Behavior Analysis, and Healthcare Data Privacy with Blockchain. These articles collectively advance our understanding of AI applications in healthcare and reveal significant advancements in diagnostic accuracy, patient monitoring, data security and predictive analytics. Additionally, this review discusses the research findings and implications that will lead to groundbreaking insights in real‐world applications, which could provide a clear path for learning a current healthcare technology in mobile health with AI.
Bioinformatic Analysis for Exploring Target Genes and Molecular Mechanisms of Cadmium‐Induced Nonalcoholic Fatty Liver Disease and Targeted Drug Prediction
Authors: Zhang Le , Wang Rui , Xue Qian , Wang Yongjie , Xu Jiayunzhu , Wang Chaofan , Fang Xin , Gao Shidi , Zhang Haiying , Guo Li 
Published: January 2025

ABSTRACTCadmium (Cd) is a widely available metal that has been found to have a role in causing nonalcoholic fatty liver disease (NAFLD). However, the detailed toxicological targets and mechanisms by which Cd causes NAFLD are unknown. Therefore, the present work aims to reveal the main targets of action, cellular processes, and molecular pathways by which cadmium causes NAFLD. As shown in the bioinformatics analysis, there were 74 main targets of action for cadmium‐induced NAFLD, hemopoietic cell kinase (HCK), EPH receptor A2 (EPHA2), MYC proto‐oncogene (MYC), lysyl oxidase (LOX), dipeptidyl peptidase 7 (DPP7), nuclear factor erythroid 2‐related factor 2 (NFE2L2), dual specificity phosphatase 6 (DUSP6), CD2 cytoplasmic tail binding protein 2 (CD2BP2), notch receptor 3 (NOTCH3), and phospholipase A2 group IVA (PLA2G4A) were screened as core genes. Testing these core genes in other databases, three differentially expressed genes, HCK, MYC, and DUSP6 were verified and used as targets for drug prediction in DsigDB; decitabine and retinoic acid were screened as potential therapeutic drugs for NAFLD based on the p‐value and the combined score. The results of molecular docking showed that the predicted drugs can bind well to the core targets. In conclusion, cadmium is associated with NAFLD; the identified cadmium‐toxicity targets, HCK, MYC, and DUSP6, may serve as biomarkers for the diagnosis of NAFLD and predicted drugs, decitabine and retinoic acid may have a potential role in the treatment of NAFLD.
Mechanical Analysis of Phellinus Linteus‐Induced Apoptosis of Hepatoma Cells
Authors: Huang Yuxi , Yang Fan , Liu Chuanzhi , Wang Jianfei , Wang Ying , Song Guicai , Wang Zuobin 
Published: January 2025

ABSTRACTLiver cancer is prevalent with the third highest mortality rate globally. The biomechanical properties of cancer cells play a crucial role in their proliferation and differentiation. Studying the morphological and mechanical properties of individual living cells can be helpful for early diagnosis of cancers. Herein, atomic force microscopy (AFM) was used to investigate the effects of Phellinus linteus on hepatocyte cells (HL‐7702) and hepatocellular carcinoma cells (SMCC‐7721) in terms of morphological and mechanical changes at the nanoscale. The water extract of Phellinus linteus (PLWE) resulted in increased height and surface roughness of SMCC‐7721 cells. Also, the PLWE‐treated showed that the average adhesion decreased by 1.69 nN and the average Young's modulus increased by 0.379 kPa. Additionally, the SMCC‐7721 cells treated with PLWE showed clearly reduced activity compared with HL‐7702 cells. This study suggested that Phellinus Linteus could be a potential candidate for selective anti‐cancer therapy, providing a new avenue for the treatment of hepatocellular carcinoma.
Cystathionine β‐Synthase Deficiency in the E‐HOD Registry—Part II: Dietary and Pharmacological Treatment
Authors: Morris Andrew A. M. , Sokolová Jitka , Pavlíková Markéta , Gleich Florian , Kölker Stefan , Dionisi‐Vici Carlo , Baumgartner Matthias R. , Hannibal Luciana , Blom Henk J. , Huemer Martina , Kožich Viktor ,   E‐HOD Consortium
Published: January 2025

ABSTRACTCystathionine β‐synthase (CBS) deficiency (classical homocystinuria) has a wide range of severity. Mildly affected patients typically present as adults with thromboembolism and respond to treatment with pyridoxine. Severely affected patients usually present during childhood with learning difficulties, ectopia lentis and skeletal abnormalities; they are pyridoxine non‐responders (NR) or partial responders (PR) and require treatment with a low‐methionine diet and/or betaine. The European network and registry for Homocystinurias and methylation Defects (E‐HOD) has published management guidelines for CBS deficiency and recommended keeping plasma total homocysteine (tHcy) concentrations below 100 μmol/L. We have now analysed data from 311 patients in the registry to see how closely treatment follows the guidelines. Pyridoxine‐responsive patients generally achieved tHcy concentrations below 50 μmol/L, but many NRs and PRs had a mean tHcy considerably above 100 μmol/L. Most NRs were managed with betaine and a special diet. This usually involved severe protein restriction and a methionine‐free amino acid mixture, but some patients had a natural protein intake substantially above the WHO safe minimum. Work is needed on the methionine content of dietary protein as estimates vary widely. Contrary to the guidelines, most NRs were on pyridoxine, sometimes at dangerously high doses. tHcy concentrations were similar in groups prescribed high or low betaine doses and natural protein intakes. High tHcy levels were probably often due to poor compliance. Comparing time‐to‐event graphs for NR patients detected by newborn screening and those ascertained clinically showed that treatment could prevent thromboembolism (risk ratio 0.073) and lens dislocation (risk ratio 0.069).
A Disposable Pipette Extraction‐UHPLC‐MS/MS Method Based on Removal of Phospholipids to Determine Anandamide, 2‐Arachidonoylglycerol, Cannabidiol, and Δ9‐Tetrahydrocannabidiol in Plasma Samples
Authors: Oliveira Igor Gustavo Carvalho , de Souza Israel Donizeti , de Crippa José Alexandre de Souza , Queiroz Maria Eugênia Costa 
Published: January 2025

ABSTRACTCannabidiol (CBD) and Δ9‐tetrahydrocannabinol (THC), the main components of Cannabis sativa plants, can interact with specific cell receptors known as cannabinoid receptors (CBs). The endogenous compounds anandamide (AEA) and 2‐arachidonoylglycerol (2‐AG) are CB agonists, and, alongside enzymes, they constitute the endocannabinoid system (ECS) and take part in neuromodulation. Several LC‐MS/MS methods have been developed to quantify these compounds in biological matrixes, but a fast and simple method that can determine these analytes in plasma samples simultaneously is not available. Here, we propose a disposable pipette extraction technique containing a zirconia‐based sorbent (DPX(Zr)) combined with UHPLC‐MS/MS analysis to determine CBD, THC, AEA, and 2‐AG in plasma samples, simultaneously. The method combines simple protein precipitation (PPT) with a one‐step DPX procedure to remove phospholipids, one of the most common endogenous interferents in biological samples. Optimization of the combined PPT‐DPX sample preparation method reduced the matrix effect and improved the sensitivity of the analytical method. The validated DPX(Zr)‐UHPLC‐MS/MS method reported LLOQs of 0.1 ng mL−1 for AEA and 2‐AG and 1 ng mL−1 for CBD and THC. The method demonstrated intra‐ and interassay accuracy and precision of less than 20% for the LLOQ, and less than 15% for the other calibration points. Additionally, no carryover or significant matrix effect was observed. We applied this method to determine AEA, 2‐AG, and CBD in plasma samples obtained from obsessive‐compulsive disorder patients treated with CBD.
Mechanoluminescence from Lead‐Free Perovskites Cs2HfCl6: Te4+
Authors: Yan Shuangpeng , Song Hao , Liu Ya , Xu Xuhui , Peng Songcheng , Yang Xiuxia , Teng Zhaowei 
Published: January 2025

AbstractMechanoluminescence (ML) has always attracted much attention due to the broad prospects in various fields. However, the types of ML materials are still limited. Here, the traps are introduced by means of X‐ray irradiation, and finally a high brightness ML visible to the naked eye during daytime and a 20 s ML afterglow is obtained in Cs2HfCl6: Te4+ Inorganic Lead‐free halide perovskites (ILFHPs). This work will promote the further development of ML and provide a way of thinking for the exploration of new materials.
Land Misallocation and Urban Green Innovation: From the Perspective of Asymmetrical Innovation Theory
Authors: Xu Hengzhou , Sun Fenghui , Liu Shuangliang 
Published: January 2025

ABSTRACTAs the conflict between economic growth and environmental pollution intensifies, green innovation is gradually recognized as a pivotal strategy for promoting sustainable urban development. The unique institution is an important asymmetric resource for innovation activities, so delving into China's land institutional context represents a significant direction for both the theoretical understanding and practical application research of innovation in China. The existing framework inadequately explores the nexus between land misallocation (LM) and urban green innovation (UGI) and fails to reveal the underlying transmission mechanism fully. To bridge this gap, this paper utilizes city‐level data from China spanning 2007 to 2020, takes an asymmetric innovation perspective, and empirically tests the impact of two types of land misallocation, industrial LM and sectoral LM, on the relationship between UGI. The results reveal that LM has a significantly direct negative impact on UGI in China. The results are still robust after changing the sample size, substituting explanatory variables, replacing regression models, and running endogeneity tests. Additionally, the negative impact of LM exhibits heterogeneity within sectors and cities of different economic levels, administrative ranks, and dominant industries. The mechanism testing results indicate that LM affects UGI through structural, scale, and agglomeration effects. These conclusions enrich the literature on the impact of institutions on urban green innovation and provide valuable insights into the sustainable development of cities.
Two‐Dimensional Jet Flows for Compressible Full Euler System With General Vorticity
Authors: Li Yan 
Published: January 2025

ABSTRACTIn this paper, we consider the well‐posedness theory of two‐dimensional compressible subsonic jet flows for steady full Euler system with general vorticity. We show that the stream function formulation for such system admits a variational structure. Then the existence and uniqueness of a smooth subsonic jet flow can be established by the variational method developed by Alt, Caffarelli and Friedman. Furthermore, the far fields behavior of the flow and the existence of a critical upstream pressure are also obtained.
A New Dual‐Band Filtering Power Divider Based on a Single Multimode Modified Triangle Patch Resonator
Authors: Li Yijun , Ni Jinxuan , Gao Qiyue , Zhou Xin , Liu Zhengkang , Li Na , Zhang Gang 
Published: January 2025

ABSTRACTThis letter proposes a new design of a dual‐band (DB) filtering power divider (FPD) on a single multimode‐modified triangle patch resonator. The proposed design leverages the resonant characteristics of an equilateral triangle patch resonator to exploit the TM10, TM11, TM21, and TM30 resonant modes within a single multimode‐modified triangle patch resonator, enabling the realization of an FPD with DB operation. To achieve two assumed second‐order filtering passbands, a metal via and multiple perturbed slots are introduced, providing flexible control over the resonant mode frequencies. The first passband is formed by the TM10 and TM11 modes, while the second passband is formed by the TM21 and TM30 modes. To ensure in‐band isolation for both passbands, two sets of isolation networks are developed. A prototype is designed, fabricated, and measured to validate the proposed method. The measured results demonstrate excellent agreement with the simulated ones.
Online Learning and Pricing for Multiple Products With Reference Price Effects
Authors: Ji Sheng , Yang Yi 
Published: January 2025

ABSTRACTWe consider the dynamic pricing problem of a monopolist seller who sells a set of mutually substitutable products over a finite time horizon. Customer demand is sensitive to the price of each individual product and the reference price which is formed from a comparison among the prices of all products. To maximize the total expected profit, the seller needs to determine the selling price of each product and also select a reference product (to be displayed) that affects the consumer's reference price. However, the seller initially knows neither the demand function nor the optimal reference product, but can learn them from past observations on the fly. As such, the seller faces the classical trade‐off between exploration (learning the demand function and reference price) and exploitation (using what has been learned thus far to maximize revenue). We propose a rate‐optimal dynamic learning‐and‐pricing algorithm that integrates iterative least squares estimation and bandit control techniques in a seamless fashion. We show that the cumulative regret, that is, the expected revenue loss caused by not using the optimal policy over periods, is upper bounded by where hides any logarithmic factors. We also establish the regret lower bound (for any learning policies) to be . We then generalize our analysis to a more general demand model. Our algorithm performs consistently well numerically, outperforming an exploration‐exploitation benchmark. The use of price experimentation and estimation techniques could be readily applied in real retail management.
Multitopology Routing With Virtual Topologies and Segment Routing
Authors: Huin Nicolas , Martin Sébastien , Leguay Jérémie 
Published: January 2025

ABSTRACTMultitopology routing (MTR) provides an attractive alternative to segment routing (SR) for traffic engineering when network devices cannot be upgraded. However, due to a high overhead in terms of link state messages exchanged by topologies and the need to frequently update link weights to follow evolving network conditions, MTR is often limited to a small number of topologies and the satisfaction of loose QoS constraints. To overcome these limitations, we propose virtual MTR (vMTR), an MTR extension where demands are routed over virtual topologies that are silent; that is, they do not exchange LSA messages and that are continuously derived from a very limited set of real topologies, optimizing each QoS parameter. In this context, we present a polynomial and exact algorithm for vMTR and, as a benchmark, a local search algorithm for MTR. We show that vMTR helps to reduce drastically the number of real topologies and that it is more robust to QoS changes. In the case where SR can actually be rolled‐out, we also show that vMTR allows to drastically reduce SR overhead.
Preparation of Porous Novel QuEChERS Adsorbent ZIF‐67/PAA/PES Composite Microspheres and Their Application for Rapid Adsorption of Triphenylmethane Dyes in Wastewater and Fish
Authors: Wang Xiaotian , Aheyeli‐kai Yeerken , Ying Huakun , Lin Jiangli , Luo Yulu , Ma Hongying , Li Zhongyang , Su Zhen 
Published: January 2025

ABSTRACTTriphenylmethane dyes have a wide range of applications in textiles, pharmaceuticals, food, and other fields. Malachite green (MG), fuchsin acid (FA), and crystalline violet (CV) were typical representatives of triphenylmethane dyes, and they are carcinogenic and mutagenic to aquatic organisms and environment. However, they need to be separated and enriched for their accurate quantification due to their low content. Therefore, it is important to develop a rapid and accurate enrichment method to monitor these dyes in aquatic systems for human health. In this paper, a novel QuEChERS adsorbent porous ZIF67/PAA/PES composite microspheres were prepared and applied for the rapid adsorption of triphenylmethane dyes in wastewater and fish samples, which improved the adsorption capacity and the analytical sensitivity of the targets. The experimental results demonstrated that the porous ZIF‐67/PAA/PES composite microspheres exhibited excellent selective adsorption capacity of MG, FA, and CV, and after six adsorption–desorption cycles, the material adsorption amount can reach more than 90% of its original adsorption amount in wastewater. In addition, the porous ZIF67/PAA/PES composite microspheres were applied as QuEChERS adsorbents for the enrichment of MG and CV dyes in fish, and the adsorption rates of the dyes were 99.11% and 99.03%, with the RSDs of 1.58% and 1.27%, respectively. The limits of detection were 0.0093 and 0.0127 mg/L for MG and CV. Through the Langmuir adsorption isotherm models to predict the MG, FA, and CV of the maximum adsorption capacity were 5417.3622, 2119.9011, and 1654.1026 mg/g, respectively. Thus, the novel porous ZIF67/PAA/PES composite microspheres are more advantageous as QuEChERS adsorbents for sample pre‐treatment and have very important research significance.