bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perceptions of social media utilization among orthopaedic foot and ankle surgeons
Authors: Salimy Mehdi S. , Narain Ankur S. , Curtin Patrick B. , Bellinger Eric C. , Patel Abhay R. 
Published: September 2023

AbstractBackgroundThe growing social media presence in healthcare has provided physicians with new ways to engage with patients. However, foot and ankle orthopaedic surgeons have been found to underuse social media platforms despite their known benefits for patients and surgeons. Thus, this study sought to investigate the reasons for this phenomenon and to identify potential barriers to social media utilization in clinical practice.MethodsA 19‐question survey was distributed to active attending physicians identified through the American Orthopaedic Foot & Ankle Society membership database. The survey included demographic, practice characteristics, and social media use questions assessed by a 5‐point Likert scale. Logistic regression was used to identify predictors of positive attitudes toward social media.ResultsFifty‐eight surgeons were included. Most respondents were male (n = 43, 74.1%), in private practice (n = 31, 53.5%), and described their practice to be greater than 51% elective procedures (n = 46, 79.4%). The average years in practice was 14.8 years (standard deviation, SD: 10.0 years). A total of 32.8% (n = 19) of surgeons reported using social media as part of their clinical practice. Facebook (n = 19, 32.8%), a professional website or blog (n = 18, 31.0%), and LinkedIn (n = 15, 25.9%) were the most used platforms–primarily for practice marketing or brand development (n = 19, 32.8%). A total of 58.6% (n = 34) of surgeons reported they did not use social media. The primary reasons were the time commitment (n = 31, 53.5%), concerns about obscuring professional boundaries (n = 22, 37.9%), and concerns regarding confidentiality (n = 11, 19.0%). Many surgeons reported that social media positively influences foot and ankle surgery (n = 23, 39.7%), although no individual predictors for these views could be identified.ConclusionsFoot and ankle orthopaedic surgeons tended to view social media use positively, but the time investment and concerns over professionalism and confidentiality pose challenges to its use. Given the influence of a surgeon's social media identity on patient satisfaction and practice building, efforts should be made to streamline social media use for foot and ankle surgeons to establish their online presence.Level of evidenceLevel IV, cross‐sectional study.
Post-trigger luteinizing hormone concentration to positively predict oocyte yield in the antagonist protocol and its association with genetic variants of LHCGR
Authors: Jin Hao , Yang Haiyan , Zheng Jiujia , Zhou Jiechun , Yu Rong 
Published: September 2023

Abstract
Background
The concentration of human chorionic gonadotropin (hCG)/ luteinizing hormone (LH) after triggering is generally accepted as a predictor of the normal ovarian response to the trigger, but few studies have explored the distribution model of concentration and its impact on oocyte yield. Genetic variations in LHCGR, known as a receptor for hCG and LH, also play a role in oocyte maturation and retrieval. The objective of the study was to investigate the impact of concentrations of hCG/LH after triggering on oocyte yield and its association with genetic variants of LHCGR.

Methods
A retrospective cohort study including 372 antagonist IVF cycles, in which 205 received the recombinant hCG trigger and 167 received the gonadotropin-releasing hormone agonist (GnRH-a) trigger, was conducted. The post-trigger concentrations of hCG/LH and the LHCGR N312S (rs2293275) genotype were evaluated in patients to analyse the impact of these factors on oocyte yield.

Results
The oocyte retrieval rate (ORR) increased significantly among the low-, medium- and high-hCG-concentration groups (0.91 ± 0.25, 0.99 ± 0.23 and 1.08 ± 0.19, P < 0.001) and among the low-, medium- and high-LH-concentration groups (0.80 ± 0.29, 0.95 ± 0.21 and 1.07 ± 0.19, P < 0.001). The Pearson correlation coefficient between the post-trigger hCG concentration and ORR was 0.242 (P < 0.001), and that between the LH concentration and ORR was 0.454 (P < 0.001). After adjustment for confounding factors, high post-trigger LH concentrations remained associated with the significantly higher ORRs (adjusted R2 = 0.541, P < 0.001). Patients with the AG genotype of LHCGR N312S were more likely to have low post-trigger LH concentrations (46.10 IU/L versus 60.91 IU/L, P < 0.001) and a significantly lower ORR (0.85 versus 0.96, P = 0.042) than patients with the GG genotype after the GnRH-a trigger.

Conclusions
The post-trigger LH concentration can positively predict oocyte yield in antagonist IVF cycles, and patients with the AG genotype of LHCGR rs2293275 could have a suboptimal oocyte yield using the GnRH-a trigger.
Upper body compression wear improves muscle oxygenation following intense video game training: a randomized cross-over study among competitive gamers
Authors: DiFrancisco-Donoghue Joanne , Rothstein Alexander , Jung Min-Kyung , Zwibel Hallie , Werner William G 
Published: September 2023

Abstract
Background
Esport players require a high number of action moves per minute to play, with substantial contractions of the wrist extensor muscles. Players frequently suffer from acute fatigue. The purpose of this study was to examine the use of below the elbow compression sleeves on Sm02 during intense aim training. Secondly, to examine players’ performance and perception with and without compression.

Methods
This study was conducted at the New York Institute of Technology and enrolled fifteen collegiate esport players, 2 women and 13 men (age 21.2 ± 2.2). All subjects signed written consent. Participants performed 3 high intensity bouts of an aim trainer followed by a 15-minute rest before doing another 3 bouts of high intensity training conducting the other arm of the study. The compression wear order was randomized. The primary outcome included Sm02 of the extensor carpi radialis longus using near-infrared spectrometry. Secondary outcomes included Kills Per Second (KPS), Score, Total Time to Kill (TTK), accuracy, and perceived performance.

Results
Following 15 min of recovery, there was a significant rise in Sm02 while wearing the compression sleeve compared to no compression sleeve (p = 0.004). No change in Sm02 was seen while gaming. In trials 1 and 2, wearing the compression sleeve resulted in a significant increase in KPS and score when compared to not wearing it (p = 0.002,0.006). Although TTK and accuracy did not alter, 46.7% of participants believed the compression sleeve aided their performance.

Conclusions
This study provides support that wearing below the elbow upper body compression sleeves while performing high intensity gaming may reduce fatigue, improve muscle recovery and gaming performance.

Trial registration
Clinicaltrials.gov identifier NCT05037071. Registered 08/09/2021. URL: Arm Compression on Muscle Oxygen Saturation - Full Text View - ClinicalTrials.gov
Use of electronic health record data mining for heart failure subtyping
Authors: Vuori Matti A. , Kiiskinen Tuomo , Pitkänen Niina , Kurki Samu , Laivuori Hannele , Laitinen Tarja , Mäntylahti Sampo , Palotie Aarno , FinnGen  , Niiranen Teemu J. 
Published: September 2023

Abstract
Objective
To assess whether electronic health record (EHR) data text mining can be used to improve register-based heart failure (HF) subtyping. EHR data of 43,405 individuals from two Finnish hospital biobanks were mined for unstructured text mentions of ejection fraction (EF) and validated against clinical assessment in two sets of 100 randomly selected individuals. Structured laboratory data was then incorporated for a categorization by HF subtype (HF with mildly reduced EF, HFmrEF; HF with preserved EF, HFpEF; HF with reduced EF, HFrEF; and no HF).

Results
In 86% of the cases, the algorithm-identified EF belonged to the correct HF subtype range. Sensitivity, specificity, PPV and NPV of the algorithm were 94–100% for HFrEF, 85–100% for HFmrEF, and 96%, 67%, 53% and 98% for HFpEF. Survival analyses using the traditional diagnosis of HF were in concordance with the algorithm-based ones. Compared to healthy individuals, mortality increased from HFmrEF (hazard ratio [HR], 1.91; 95% confidence interval [CI], 1.24–2.95) to HFpEF (2.28; 1.80–2.88) to HFrEF group (2.63; 1.97–3.50) over a follow-up of 1.5 years. We conclude that quantitative EF data can be efficiently extracted from EHRs and used with laboratory data to subtype HF with reasonable accuracy, especially for HFrEF.
From fossil trader to paleontologist: on Swiss-born naturalist Santiago Roth and his scientific contributions
Authors: Sánchez-Villagra Marcelo R. , Bond Mariano , Reguero Marcelo , Bartoletti Tomás 
Published: September 2023

AbstractRoth’s explorations, the resulting collections many now allocated in La Plata, Zurich, Geneva and Copenhagen, and his significant contributions in geological—especially stratigraphic—and paleontological topics, are a paradigmatic case for the global history of paleontology and for the Swiss migration history in Latin America. His work included the discovery of a diverse megafauna from the Pampean region, of sites and strata in Patagonia of paleontological significance, and the recognition of a group of endemic ungulate mammals, Notoungulata. Roth’s discovery of a human skeleton associated with a glyptodont carapace is one of the first reports of the coexistence of humans with the extinct fauna of the South American Quaternary. Roth became a renowned scholar at the Museo de La Plata, which was a leading scientific institution in the nation-making of Argentina, particularly in the expansion of the Patagonian frontier. He also kept strong ties with his native Switzerland, where late in his adult life he obtained some formal training and tried to attract other Swiss nationals to work in natural sciences in Argentina. His biography sheds light about the circumstances of his scientific collection and career in the interstices between amateur and professional science, modernity and imperialism at the turn of the twentieth century.
Adherence enhancing interventions for pharmacological and oxygen therapy in patients with COPD: protocol for a systematic review and component network meta-analyses
Authors: Ammous Omar , Andreas Stefan , Friede Tim , Kampo Regina , Schwarz Sarah , Wollsching-Strobel Maximilian , Salem Susanna , Windisch Wolfram , Mathes Tim 
Published: September 2023

Abstract
Background
Chronic obstructive pulmonary disease (COPD) is characterised by hyperinflation and expiratory airflow limitation due to long-term exposure to irritants. The variety and complexity of COPD treatment and the possible added comorbidities may make the patients find it difficult to cope with the required medications. That is why supporting patients’ adherence is critical because not taking medications correctly increases the risk of complications and creates an additional financial burden. A range of interventions aiming to improve patient adherence were used, and most of them are complex since they involve a mix of elements. Furthermore, despite the variety of available tools, assessing adherence is challenging because clinicians usually do not get a concrete judgement if their patients followed their treatment plan reliably. We aim to evaluate the effectiveness of adherence-enhancing interventions for COPD patients, explore which intervention (component) works for which patients and check the factors influencing the implementation and participant responses.

Methods
We will perform a comprehensive literature search (Medline, Embase, Cochrane Library, trial registries) without restrictions on language and publication status, and we will include all controlled studies investigating the effect of adherence-enhancing intervention on patients with COPD. We plan to involve COPD patients in the systematic review development through two patient interviews (one before and one after the systematic review). Two reviewers will perform the screening, data extraction and risk of bias (ROB) assessment. For ROB, we will use ROB 2.0 to assess randomised controlled trials, and ROBINS-I to assess non-randomised studies. We will perform pair-wise random-effects meta-analyses and component network meta-analyses to identify the most effective components and combinations of components. We will use the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) approach to assess the quality of evidence. To determine the degree of complexity, we will use the iCAT_SR checklist, and then, following a logical model, we will group the interventions according to prespecified criteria.

Discussion
This systematic review aims to point out the most effective and implementable adherence-enhancing interventions by using methods for synthesising evidence on complex interventions and involving COPD patients all along with the review process.

Systematic review registration
PROSPERO CRD42022353977
Impact factors of Blastocystis hominis infection in persons living with human immunodeficiency virus: a large-scale, multi-center observational study from China
Authors: Zhang Shun-Xian , Wang Ji-Chun , Li Zhong-Wei , Zheng Jin-Xin , Zhou Wen-Ting , Yang Guo-Bing , Yu Ying-Fang , Wu Xiu-Ping , Lv Shan , Liu Qin , Chen Mu-Xin , Lu Yan , Dou Zhi-Hui , Zhang Da-Wei , Lv Wen-Wen , Wang Lei , Lu Zhen-Hui , Yang Ming , Zheng Pei-Yong , Chen Yue-Lai , Tian Li-Guang , Zhou Xiao-Nong 
Published: September 2023

Abstract
Background
Blastocystis hominis (Bh) is zoonotic parasitic pathogen with a high prevalent globally, causing opportunistic infections and diarrhea disease. Human immunodeficiency virus (HIV) infection disrupts the immune system by depleting CD4+ T lymphocyte (CD4+ T) cell counts, thereby increasing Bh infection risk among persons living with HIV (PLWH). However, the precise association between Bh infection risk and HIV-related biological markers and treatment processes remains poorly understood. Hence, the purpose of the study was to explore the association between Bh infection risk and CD4+ T cell counts, HIV viral load (VL), and duration of interruption in antiviral therapy among PLWH.

Methods
A large-scale multi-center cross-sectional study was conducted in China from June 2020 to December 2022. The genetic presence of Bh in fecal samples was detected by real-time fluorescence quantitative polymerase chain reaction, the CD4+ T cell counts in venous blood was measured using flowcytometry, and the HIV VL in serum was quantified using fluorescence-based instruments. Restricted cubic spline (RCS) was applied to assess the non-linear association between Bh infection risk and CD4+ T cell counts, HIV VL, and duration of interruption in highly active antiretroviral therapy (HARRT).

Results
A total of 1245 PLWH were enrolled in the study, the average age of PLWH was 43 years [interquartile range (IQR): 33, 52], with 452 (36.3%) being female, 50.4% (n = 628) had no immunosuppression (CD4+ T cell counts > 500 cells/μl), and 78.1% (n = 972) achieved full virological suppression (HIV VL < 50 copies/ml). Approximately 10.5% (n = 131) of PLWH had interruption. The prevalence of Bh was found to be 4.9% [95% confidence interval (CI): 3.8–6.4%] among PLWH. Significant nonlinear associations were observed between the Bh infection risk and CD4+ T cell counts (Pfor nonlinearity < 0.001, L-shaped), HIV VL (Pfor nonlinearity < 0.001, inverted U-shaped), and duration of interruption in HARRT (Pfor nonlinearity < 0.001, inverted U-shaped).

Conclusions
The study revealed that VL was a better predictor of Bh infection than CD4+ T cell counts. It is crucial to consider the simultaneous surveillance of HIV VL and CD4+ T cell counts in PLWH in the regions with high level of socioeconomic development. The integrated approach can offer more comprehensive and accurate understanding in the aspects of Bh infection and other opportunistic infections, the efficacy of therapeutic drugs, and the assessment of preventive and control strategies.

Graphical Abstract
The moderating role of optimism between social trauma and depression among Chinese college students: a cross-sectional study
Authors: Luo Jie , Cao Wei , Zhao Jianhua , Zeng Xiaojin , Pan Yun 
Published: September 2023

Abstract
Background
Although there is a robust relationship among social trauma, optimism, and depression, the inner mechanism of this correlation remains unclear and need to be further explored. The mainly purpose of the current study was to investigate the relationship between social trauma, optimism, and depression among college students in China. More specifically, examined the moderating role of the optimism between social trauma and depression in Chinese college students.

Methods
A sample of 464 Chinese college students (54.7% female, Mage=19.29) from three universities were selected by the convenient sampling, and the Social Trauma Questionnaire (STQ), the Optimism Questionnaire (OPQ), and the Self-Rating Depression (SDS) were completed by these Chinese undergraduates. The descriptive statistics, Pearson correlations, and hierarchical regression analysis were used to examine the results.

Results
(1) The social trauma was positively associated with depression, whereas the optimism was negatively associated with social trauma, and depression; (2) The social trauma had a significant correlation with depression, and the optimism could moderate the relationship between social trauma and depression. More specifically, the further study showed that there was a significant positive relation between social trauma and depression under the low optimism level, however, there was a non-significant relation between social trauma and depression under the high optimism level.

Conclusion
The optimism is the protective mechanism of college students’ mental health (e.g., depression), it could weaken the trauma that associated with social trauma among college students.
Prevalence of adenoid hypertrophy among 12-year-old children and its association with craniofacial characteristics: a cross-sectional study
Authors: Tse Kwan Lok , Savoldi Fabio , Li Kar Yan , McGrath Colman P. , Yang Yanqi , Gu Min 
Published: September 2023

Abstract
Background
Identifying the prevalence of adenoid hypertrophy (AH) and craniofacial factors associated with this condition requires studies with random sampling from the general population, and multiple criteria can be used for assessing AH on lateral cephalometric radiograph (LCR). The present analysis represents the first report performed according to these requirements in a large cross-sectional sample of children.

Methods
LCRs of 517 12-year-old children (286 males, 231 females) randomly selected from the general population were retrospectively retrieved. AH was defined using three criteria (At/Nd, Ad-Ba/PNS-Ba, 1-Npaa/Npa), and twelve craniofacial variables were measured (SNA, SNB, ANB, Wits, Cd-Gn, MnP^SN, MxP^MnP, TPFH/TAFH, OPT^SN, C2ps-C4pi^SN, H-CV, H-FH). Skeletal characteristics were compared between children with and without AH using Mann–Whitney U test. Binary logistic regression (adjusted for sex and skeletal growth) was used to independently quantify the association between craniofacial factors and AH.

Results
The prevalence of children with AH was 17.6% (according to At/Nd), 19.0% (according to Ad-Ba/PNS-Ba), and 13.9% (according to 1-Npaa/Npa). Children with AH presented greater antero-posterior jaw discrepancy (larger ANB, smaller SNB), greater mandibular divergence (larger MnP^SN), forward head posture (larger OPT^SN and C2ps-C4pi^SN), and anteriorly positioned hyoid bone (larger H-CV). Larger SNA (OR = 1.39–1.48), while smaller SNB (OR = 0.77–0.88) and Wits (OR = 0.85–0.87), were associated with greater likelihood of having AH, independently from the assessment method used.

Conclusions
The prevalence of children with AH ranged from 13.9 to 19.0% based on LCR. Greater antero-posterior maxillo–mandibular discrepancy and mandibular retrusion were independently associated with higher likelihood of having AH.
Lessons from conducting a participatory evaluation of a kinship navigator program
Authors: Moldow Erika , Anderson Virgie M. , Benjamin Stephanie LaShay , Johnson Barbara Patricia , McGuan Elizabeth , Xenakis Donna , Shields Alexandra Piñeros , Xu Yanfeng 
Published: September 2023

Abstract
Background
Approximately one in ten children globally live with kinship caregivers—relatives and family friends who step in to care for a child when parents are unable to do so. When families take on the role of informal kinship care—care of a child outside of the child welfare system—they often do so without financial assistance and advice in navigating the systems of support available to them. This is the unique role of kinship navigator programs in the U.S: to provide kinship caregivers a single point of entry for connecting to needed resources such as financial, health, housing, and legal assistance.

Methods
To the best of our knowledge, our team conducted one of the only participatory evaluations in which kinship caregivers were involved in all stages of evaluating a kinship navigator program—from designing the questions, to collecting and analyzing the data, to reporting the results. Black kinship caregivers took on decision-making power leading this formative evaluation of a kinship navigator program within one nonprofit organization in a Southeastern state.

Findings
In this paper we reflect on our process and offer lessons learned from engaging in participatory evaluation that may apply to the field of kinship care and across social service delivery more broadly. We focus on (1) ensuring the nonprofit’s commitment to the study, (2) maintaining engagement through building relationships and facilitating a culture of learning within the study team, (3) sharing decision-making power so that people with lived experience have the authority and ownership to lead the evaluation, (4) developing team members’ skills, confidence, and sense of belonging, and (5) increasing the likelihood the nonprofit will act on the study findings.

Conclusion
Through this process, we learned that participatory evaluation is a feasible and useful approach both to understanding the experiences of kinship families and to improving the supports in their lives. We hope this paper will inspire others to draw on the strengths and capacity of people with lived experience to engage in participatory evaluation. Greater recognition of the value of this approach in social change and increased funding to carry out the process are both needed.
“Why involve older people in research?” Revisiting Alan Walker’s earlier editorial based on recent experiences from the UserAge research programme
Authors: Hultqvist Sara , Hanson Elizabeth , Jönson Håkan , Slaug Björn , Iwarsson Susanne 
Published: September 2023

AbstractPosed 16 years ago in a much-cited editorial by gerontologist, Alan Walker, “Why involve older people in research?” is a question that has since inspired researchers in many countries and from diverse disciplines. In Sweden, researchers and older people have been collaborating in the 6-year UserAge research programme, focusing on user involvement in research on ageing and health, UserAge aims at contributing to an in-depth understanding of the challenges and benefits of user involvement in different phases of the research process. Approaching programme completion, the authors take the opportunity to dwell upon current reasons for and modes of user involvement in ageing research in light of the argument originally put forward by Alan Walker back in 2007.