bluuebunny/crossref_metadata_2025_split huggingface dataset:
Water fluxes contribute to growth patterning in shoot meristems
Authors: Alonso-Serra Juan , Cheddadi Ibrahim , Kiss Annamaria , Cerutti Guillaume , Lionnet Claire , Godin Christophe , Hamant Olivier 
Published: August 2023

AbstractIn multicellular organisms, localized tissue outgrowth creates a new water sink thereby modifying hydraulic patterns at the organ level. These fluxes are often considered passive by-products of development and their patterning and potential contribution to morphogenesis remains largely unexplored. Here, we generated a complete map of cell volumetric growth and deformation across the shoot apex inArabidopsis thaliana. Within the organ-meristem boundary, we found that a subpopulation of cells next to fast-growing cells experiences volumetric shrinkage. To understand this process, we used a vertex-based model integrating mechanics and hydraulics, informed by the measured growth rates. Organ outgrowth simulations revealed the emerging water fluxes and predicted water deficit with volume loss for a few cells at the boundary. Consistently,in planta,a water-soluble dye is preferentially allocated to fast-growing tissues and fails to enter the boundary domain. Analysis of intact meristems further validated our model by revealing cell shrinkage next to fast-growing cells in different contexts of tissue surface curvature and cell deformation. A molecular signature of water deficit at the boundary further confirmed our conclusion. Taken together, we propose a model where the differential sink strength of emerging organs prescribes the hydraulic patterns that define the boundary domain at the shoot apex.
Kinase inhibitor-induced cell-type specific vacuole formation in the absence of canonical ATG5-dependent autophagy
Authors: Jose Susan , Sharma Himanshi , Insan Janki , Sharma Khushboo , Arora Varun , Dhamija Sonam , Eid Nabil , Menon Manoj B. 
Published: August 2023

AbstractPyridinyl imidazole class p38 MAPKα/β (MAPK14/MAPK11) inhibitors including SB202190 have been shown to induce a cell-type specific defective autophagy response resulting in micron-scale vacuole formation, autophagy-dependent death, and tumor growth suppressionin vivo.We had earlier shown that this is an off-target effect of SB202190. Here we provide evidence that the cell-type specific vacuole formation is independent of canonical autophagy pathway. While SB202190 seems to interfere with autophagic flux in many cell lines in parallel to vacuolation, autophagy-deficient DU-145 cells and CRISPR/Cas9 gene-edited ATG5 knockout A549 cells also undergo vacuolation upon SB202190 treatment. Late-endosomal GTPase RAB7 colocalizes with these compartments and RAB7 GTP-binding seems to be essential for SB202190-induced vacuolation. RAB7 is a driver of tumor progression and interfering with RAB7-positive endo/lysosomal compartments may enhance cytotoxicity. A screen for modulators of SB202190-induced vacuolation revealed molecules including multi-kinase inhibitor Sorafenib as inhibitor of vacuolation and sorafenib co-treatment enhanced the cytotoxicity of SB202190. Moreover VE-821, an ATR kinase inhibitor was found to phenocopy the cell-type specific vacuolation response of SB202190. To identify the factors determining the cell-type specificity of the vacuolation response induced by SB-compounds and VE-821, we compared the transcriptomics data from vacuole forming and non-vacuole forming cancer cell lines and identified a gene expression signature which may define sensitivity of cancer cells to these small-molecule kinase inhibitors. Further analyses using the small molecule tools and the gene signature discovered here, could reveal novel mechanisms regulating this interesting phenotype relevant to anti-cancer therapy.
ZFP57 is a regulator of postnatal growth and life-long health
Authors: Hanin Geula , Alsulaiti Boshra , Costello Kevin R , Tavares Hugo , Takahashi Nozomi , Mikheeva Liudmila A , Freeman Anjuli Karmi , Patel Shrina , Jenkins Benjamin , Koulman Albert , Ferguson-Smith Anne C 
Published: August 2023

AbstractEarly-life factors, including nutrition, shape long-term health outcomes. Despite the essential role of lactation in maternal nutritional support, the influence of epigenetic factors on lactation and postnatal growth remains poorly understood. Zinc-finger protein 57 (ZFP57), is an epigenetic regulator of genomic imprinting, a process that directs gene expression based on parental origin, playing a vital role in mammalian prenatal growth.Here, we identify a novel function of ZFP57 in regulating the mammary gland, where it serves as a key modulator of postnatal resource control, independently of imprinted genes. ZFP57 influences multiple aspects of mammary gland function, including ductal branching and cellular homeostasis. Its absence leads to significant differential gene expression, related to alveologenesis, lactogenesis and milk synthesis, associated with delayed lactation and altered milk composition. This results in life-long impacts on offspring including the development of metabolic syndrome.Cross-fostering reveals intricate dynamics between mother and offspring during lactation. Pups raised by a dam of a different genotype than their birth mother exhibit exacerbated metabolic features in adulthood, providing additional insight into the programming of offspring long-term health by maternal context. This study deepens our understanding of the interplay between epigenetic factors, lactation, and postnatal resource control and identifies ZFP57 as a major regulator of both pre and postnatal resource control in mammals.
One-year subthalamic recordings in a patient with Parkinson’s disease under adaptive deep brain stimulation
Authors: Caffi Laura , Romito Luigi Michele , Palmisano Chiara , Aloia Vanessa , Arlotti Mattia , Rossi Lorenzo , Marceglia Sara , Priori Alberto , Eleopra Roberto , Levi Vincenzo , Mazzoni Alberto , Isaias Ioannis Ugo 
Published: August 2023

SUMMARYWe present the clinical data and subthalamic recordings of a patient with Parkinson’s disease treated for one year with adaptive deep brain stimulation (aDBS). This novel stimulation mode, which adjusts the current amplitude linearly with respect to subthalamic beta power, produced a clinical benefit that was superior to the previous conventional stimulation that used constant, predefined parameters (cDBS). Compared with cDBS, the subthalamic beta amplitude was higher with aDBS and displayed larger daily fluctuations. Furthermore, subthalamic beta amplitude decreased during sleeping with respect to waking hours under aDBS. These data suggest a robust neuromodulatory mechanism of aDBS, with a clinical effect that was superior in this patient compared to cDBS. Our results open new perspectives for a restorative brain network effect of aDBS as a more physiologic, bidirectional, brain–computer interface.
Mechanical signaling through membrane tension induces somal translocation during neuronal migration
Authors: Minegishi Takunori , Hasebe Honami , Aoyama Tomoya , Naruse Keiji , Takahashi Yasufumi , Inagaki Naoyuki 
Published: August 2023

SUMMARYNeurons migrate in a saltatory manner by repeating two distinct steps: extension of the leading process and translocation of the cell body. The former step is critical for determining the migratory route in response to extracellular guidance cues. In the latter step, neurons must generate robust forces that translocate the bulky soma against mechanical barriers of the surrounding three-dimensional environment. However, the link between the leading process extension and subsequent somal translocation remains unknown. By using scanning ion conductance microscopy, we show that leading process extension increases plasma membrane tension. The tension elevation activated mechanosensitive ion channels and triggered Ca2+influx, leading to actomyosin activation at the rear of the cell. Blockade of this signaling pathway disturbed somal translocation, thereby inhibiting neuronal migration in three-dimensional environments. Thus, mechanical signaling through plasma membrane tension and mechano-channels links the leading process extension to somal translocation, allowing rapid and saltatory neuronal migration.
Investigation on corrosion tendency behaviour of TA2 titanium alloy welded joints under flow scouring conditions using the array electrode method
Authors: Liu Yingshuang , Liu Ran , Zhang Dalei , Xing Shaohua , Dou Xiaohui , Zhang Xinwei , He Zonghao 
Published: August 2023

Purpose
The corrosion behaviour of titanium alloy surface when fluid with different flow rates flows through welded joints with different residual heights was explored.

Design/methodology/approach
The experiment uses a combination of array electrodes and simulation.

Findings
It is found that when the weld reinforcement exists, the corrosion tendency of both ends of the weld metal is greater than that of other parts of the welded joint due to the influence of high turbulence kinetic energy and shear stress. The presence of weld reinforcement heights makes the fluid behind it fluctuate greatly. The passivation films of both the base metal (BM) at the rear and the heat-affected zone (HAZ) are more prone to corrosion than those of the front BM and HAZ, and the passivation film is rougher.

Originality/value
The combination of test and simulation was used to explore the influence of electrochemical and hydrodynamic factors on the corrosion behaviour of titanium alloy-welded joints when welding residual height existed.
Nonformal learning approaches and the professional development of teachers in higher education
Authors: Owusu-Agyeman Yaw 
Published: August 2023

Purpose
As universities find new ways of implementing professional development programs (PDPs), very few scholarly studies have examined how teachers could advance their knowledge and skills through PDPs that are developed based on nonformal learning approaches. To address this knowledge gap, the current study examines how PDPs could be facilitated using nonformal learning approaches to enhance the current and future professional practice of teachers in a South African University.

Design/methodology/approach
Data for the current study were gathered using semistructured face-to-face interviews among 28 teachers who were purposively sampled from the university. The interview data gathered were analyzed using thematic analysis.

Findings
The four themes that emerged from the narrative data analyzed were: developing teacher professional practice through diverse nonformal learning arrangements; challenges associated with PDPs that are designed using nonformal learning arrangements; teacher rationale for participating in PDPs that follow nonformal learning arrangements and; the role of leadership in professional development. The findings reveal that nonformal approaches are used widely in the professional development of teachers and teachers have diverse reasons for joining PDPs. Further, leadership also plays a major role in the professional development of teachers.

Practical implications
When HEIs use nonformal learning approaches to facilitate PDPs, they could 1) enable teachers to easily transfer the knowledge they acquire from the PDPs to the teaching and learning setting and 2) create a situated learning environment where experienced teachers and other experts support the professional development of young teachers.

Originality/value
This paper presents original ideas on how nonformal learning approaches could be used to facilitate PDPs and to enhance the professional practice of teachers in HEIs.
Intention of mix-mode consumer shopping service adoption: a case in the retailing context
Authors: Düzenli Özge , Felekoğlu Burcu 
Published: August 2023

PurposeThis study aims to investigate the intention of adopting a technological service innovation that is a mix-mode consumer shopping service in the retailing context.Design/methodology/approachA modified extended Unified Theory of Acceptance and Use of Technology (UTAUT2) model is tested by using data on a real example named “Mkolay” which is a new mix-mode consumer shopping service. Data are collected from 217 participants and analyzed by using Partial Least Squares Structural Equation Modeling (PLS-SEM).FindingsResearch findings show that the customers' intention to use the new mix-mode consumer shopping service is particularly influenced by performance expectations, effort expectations, social influence and personal innovativeness.Practical implicationsIn designing a mix-mode consumer shopping service, keeping the design as simple and easy to use as possible seems to increase the intention of adoption. Additionally, collaborating with reference figures or influencers could be instrumental to spread the new service to a wider audience hence increase the likelihood of adoption. Practitioners should also use new technologies in different ways to attract and surprise customers, especially taking into account the technological profile of potential users.Originality/valueThis study contributes to the literature of technological service innovation adoption by revealing the factors affecting the intention of adoption of mix-mode consumer shopping service in the retailing context with a modified UTAUT2 model.
Thermal characteristics and distribution rule of lubrication film of full ceramic ball bearing under different service condition
Authors: Sun Jian , Fang Xin , Yao Jinmei , Zhang Zhe , Guan Renyun , Zhang Guangxiang 
Published: August 2023

PurposeThe study aims to the distribution rule of lubricating oil film of full ceramic ball bearing and improve its performance and life.Design/methodology/approachThe paper established an analysis model based on the fluid–solid conjugate heat transfer theory for full ceramic ball bearings. The distribution of flow, temperature and pressure field of bearings under variable working conditions is analyzed. Meanwhile, the mathematical model of elastohydrodynamic lubrication (EHL) of full ceramic ball bearings is established. The numerical analysis is used to study the influence of variable working conditions on the lubricant film thickness and pressure distribution of bearings. The temperature rise test of full ceramic ball bearing under oil lubrication was carried out to verify the correctness of simulation results.FindingsAs the speed increased, the oil volume fraction in full ceramic ball bearing decreased and the surface pressure of rolling element increased. The temperature rise of full ceramic ball bearings increases with increasing speed and load. The lubricant film thickness of full ceramic ball bearing is positively correlated with speed and negatively correlated with load. The pressure of lubricating film is positively correlated with speed and load. The test shows that the higher inner ring speed and radial load, the higher the steady-state temperature rise of full ceramic ball bearing. The test results are in high agreement with simulation results.Originality/valueBased on the fluid–solid conjugate heat transfer theory and combined with Reynolds equation, lubricating oil film thickness formula, viscosity temperature and viscosity pressure formula. The thermal analysis model and EHL mathematical model of ceramic ball bearings are established. The flow field, temperature field and pressure field distribution of the full ceramic ball bearing are determined. And the thickness and pressure distribution of lubricating oil film in the contact area of full ceramic ball bearing were determined.Peer reviewThe peer review history for this article is available at:https://publons.com/publon/10.1108/ILT-05-2023-0126/
COVID-19-related disclosures by listed firms in Vietnam
Authors: Thi Hoang Thanh Thanh , Nguyen Huu Cuong 
Published: August 2023

Purpose
This paper aims to measure the COVID-19-related disclosure extent of listed firms in Vietnam and its associated factors.

Design/methodology/approach
The authors apply a previously developed reporting framework to evaluate the disclosures of 100 listed firms with the largest market capitalization on the Hanoi and Ho Chi Minh stock exchanges as of 31 December 2021. The disclosures were from integrated reports, annual reports, corporate governance reports and financial statements. The authors then used a regression model to examine the factors that influenced the disclosures, such as corporate governance, ownership concentration and firm profiles.

Findings
The research results reveal that the extent of COVID-19-related disclosure in Vietnam is relatively low. It also finds that the audit committee, firm size, age and industry are positively associated with the extent of COVID-19-related disclosure.

Originality/value
To the best of the authors’ knowledge, this study is the first to examine COVID-19-related disclosures of listed companies in Vietnam and their determinants. It contributes significantly to the empirical evidence in this field. The findings of this study can help corporate managers and policymakers to improve information disclosure practices during future financial crises.
Corporate social responsibility and disclosure transparency
Authors: Wild John J. , Wild Jonathan M. 
Published: August 2023

Purpose
This study aims to investigate the relation between corporate social responsibility (CSR) and disclosure transparency by examining over 12,000 disclosures of financial statements extending over 20 years. The purpose is to understand how CSR ratings relate to the level of disaggregation in financial statement line items. The study considers additional factors, such as firm size and governance, that can accentuate or moderate this relation.

Design/methodology/approach
This study applies regression analysis, including interactions, to test the magnitude of the relation between CSR ratings and disclosure transparency. CSR is measured as a composite score that ranks firms on their reputation over numerous indicators compiled by Morgan Stanley Capital International. Disclosure transparency is measured as the level of disaggregation in financial statement line items.

Findings
The study reveals evidence consistent with the notion that firms which are more CSR conscious are also more transparent with financial statements. Evidence shows that the level of transparency is more sensitive to changes in CSR for firms less CSR conscious. Firm size is found to moderate this relation, whereas enhanced governance accentuates it.

Originality/value
There is limited research on the relation between CSR ratings and disclosure transparency. To the best of the authors’ knowledge, this is the first empirical evidence on the relation between CSR ratings and the disaggregation of financial statement line items. Results from this study help us understand the drivers of disclosure transparency, which can aid regulators, investors and other stakeholders in knowing how such drivers impact managerial decisions on the disaggregation of financial statements. Accountants play a central role in producing transparent and disaggregated accounting disclosures, and their role is pivotal in effectively integrating CSR into accounting and reporting models.
Do wholesale pricing strategies matter during asymmetric disruptions? A game theoretic analysis
Authors: Raju Sarin , T.M. Rofin , S. Pavan Kumar , Jacob Jagan 
Published: August 2023

Purpose
In most economies, there are rules from the market regulators or government to sell at an equal wholesale price (EWP). But when one upstream channel is facing a negative demand disruption and another positive, EWP can create extra pressure on the disadvantageous supply chain partner, which faces negative disruption. The purpose of this study is to analyse the impact of EWP and the scope of the discriminatory wholesale price (DWP) during disruptions.

Design/methodology/approach
For the study, the authors used a dual-channel supply chain consisting of a manufacturer, online retailer (OR) and traditional brick-and-mortar (BM) retailer. Stackelberg game is used to model the interaction between the upstream and downstream channel partners, and the horizontal Nash game to analyse the interaction within downstream channel partners. For modelling asymmetric disruption, the authors took instances from the lock-down and post-lock-down periods of the COVID-19 pandemic, where consumers flow from BM retailer to OR store.

Findings
By analysing the disruption period, the authors found that this asymmetric disruption is detrimental to the BM channel, favourable to OR and has no impact on the manufacturer. But with DWP, the authors found that the profit of the BM channel and manufacturer can be increased during disruption. Though the profit of the OR decreased, it was found to be higher than in the pre-disruption period. Under DWP, the consumer surplus increased during disruption, making it favourable for the customers also. Thus, DWP can aid in creating a win-win strategy for all the supply chain partners during asymmetric disruption. Later as an extension to the study, the authors analysed the impact of the consumer transfer factor and found that it plays a crucial role in the optimal decisions of the channel partner during DWP.

Originality/value
Very scant literature analyses the intersection of DWP and disruptions. To the best of the authors’ knowledge, this study, for the first time uses DWP as a tool to help the disadvantageous supply chain partner during asymmetric disruptions. The study findings will assist the government, market regulators and manufacturers in revamping the wholesale pricing policies and strategies to help the disadvantageous supply chain partner during asymmetric disruption.
The demand-what-you-want strategy to service recovery: achieving high customer satisfaction with low service failure compensation using anchoring and precision effects
Authors: Kron Nathalie , Björkman Jesper , Ek Peter , Pihlgren Micael , Mazraeh Hanan , Berggren Benny , Sörqvist Patrik 
Published: August 2023

PurposePrevious research suggests that the compensation offered to customers after a service failure has to be substantial to make customer satisfaction surpass that of an error-free service. However, with the right service recovery strategy, it might be possible to reduce compensation size while maintaining happy customers. The aim of the current study is to test whether an anchoring technique can be used to achieve this goal.Design/methodology/approachAfter experiencing a service failure, participants were told that there is a standard size of the compensation for service failures. The size of this standard was different depending on condition. Thereafter, participants were asked how much they would demand to be satisfied with their customer experience.FindingsThe compensation demand was relatively high on average (1,000–1,400 SEK, ≈ $120). However, telling the participants that customers typically receive 200 SEK as compensation reduced their demand to about 800 SEK (Experiment 1)—an anchoring effect. Moreover, a precise anchoring point (a typical compensation of 247 SEK) generated a lower demand than rounded anchoring points, even when the rounded anchoring point was lower (200 SEK) than the precise counterpart (Experiment 2)—a precision effect.Implications/valueSetting a low compensation standard—yet allowing customers to actually receive compensations above the standard—can make customers more satisfied while also saving resources in demand-what-you-want service recovery situations, in particular when the compensation standard is a precise value.