bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tooth brushing practice in Ethiopia: a systematic review and meta-analysis
Authors: Sahile Addisu Tadesse , Wondimu Mitiku Tesfaye , Fikrie Endeshaw Mulate 
Published: April 2023

AbstractOral hygiene refers to taking care and maintaining the cleanness of gum and teeth; a good oral hygiene practice promotes better oral health in general. Oral hygiene is the top public health concern of the population. Tooth brushing is a technique to keep oral hygiene from related complications. Therefore, this study provides the pooled prevalence of tooth brushing practice in Ethiopia. Databases searched for articles systematically across PubMed, Google Scholar, Hinari, EMBASE, and African Journals Online. Two reviewers independently conducted the selection, screening, reviewing, and data extraction using a Microsoft Excel spreadsheet and used the Joanna Briggs Institute prevalence critical appraisal tools to assess the quality of evidence. All studies conducted in Ethiopia from 2010 to 2020, reporting tooth-brushing practices extracted for and imported into the Comprehensive meta-analysis version 3.0 for further analysis. Beggs and Eggers’s tests evaluated for publication bias with Higgins’s method evaluated for heterogeneity. A random-effects meta-analysis model with a 95% confidence interval was computed to estimate the pooled effect size (prevalence). Furthermore, the authors employed subgroup analysis based on the study area and sample size. After reviewing 36, 10 articles fulfilled the inclusion criteria, and were included in the meta-analysis. The pooled prevalence of tooth brushing practice was 12.2% (95% CI 7.6–19.2%). The review reported a lower level of tooth-brushing practice in Ethiopia. We recommended that special attention should be given to the oral hygiene of the Ethiopian people.
Hypoglycemia risk with inappropriate dosing of glucose-lowering drugs in patients with chronic kidney disease: a retrospective cohort study
Authors: Li Yun-Jhe , Chang Yuh-Lih , Chou Yueh-Ching , Hsu Chia-Chen 
Published: April 2023

AbstractThe incidence rates and consequences of inappropriate dosing of glucose-lowering drugs remain limited in patients with chronic kidney disease (CKD). A retrospective cohort study was conducted to estimate the frequency of inappropriate dosing of glucose-lowering drugs and to evaluate the subsequent risk of hypoglycemia in outpatients with an estimated glomerular filtration rate (eGFR) of < 50 mL/min/1.73 m2. Outpatient visits were divided according to whether the prescription of glucose-lowering drugs included dose adjustment according to eGFR or not. A total of 89,628 outpatient visits were included, 29.3% of which received inappropriate dosing. The incidence rates of the composite of all hypoglycemia were 76.71 and 48.51 events per 10,000 person-months in the inappropriate dosing group and in appropriate dosing group, respectively. After multivariate adjustment, inappropriate dosing was found to lead to an increased risk of composite of all hypoglycemia (hazard ratio 1.52, 95% confidence interval 1.34, 1.73). In the subgroup analysis, there were no significant changes in the risk of hypoglycemia regardless of renal function (eGFR < 30 vs. 30–50 mL/min/1.73 m2). In conclusion, inappropriate dosing of glucose-lowering drugs in patients with CKD is common and associated with a higher risk of hypoglycemia.
TET3 as a non-invasive screening tool for the detection of fibrosis in patients with chronic liver disease
Authors: Feng Lin-Lin , Liu Ran-Yang , An Kun , Tang Shuang , Wu Jun , Yang Qin 
Published: April 2023

AbstractTen-eleven translocation protein 3 (TET3) is one of the key enzymes in DNA demethylation which can be expressed in liver tissues. However, the clinical value of TET3 for diagnosis and treatment of chronic liver disease have not been reported previously. We investigated the diagnostic accuracy of serum TET3 as a non-invasive screening tool for liver fibrosis. 212 patients with chronic liver disease from were enrolled in this study. Enzyme-linked immunosorbent assay was used to measure the serum levels of TET3. Receiver operating characteristics (ROC) were determined to examine the diagnostic accuracy of TET3 and combination model for diagnosis fibrosis. Serum TET3 level in fibrosis cases was significantly higher than that in non-fibrosis and controls, respectively. The areas under the ROC curve of the TET3 and fibrosis-4 index for liver fibrosis were 0.863 and 0.813, and 0.916 and 0.957 for liver cirrhosis. The combination of TET3 and fibrosis-4 index had a highly promising positive predictive value for detecting liver fibrosis and cirrhosis different stages of (93.5% and 100%) as compared with each diagnostic tool alone. TET3 is related to the development of liver fibrosis and cirrhosis. The TET3-fibrosis-4 model enhances discriminatory power and represents a promising non-invasive tool for the diagnosis and screening of liver fibrosis.
Quantitative image-based collagen structural features predict the reversibility of hepatitis C virus-induced liver fibrosis post antiviral therapies
Authors: Gole Laurent , Liu Feng , Ong Kok Haur , Li Longjie , Han Hao , Young David , Marini Gabriel Pik Liang , Wee Aileen , Zhao Jingmin , Rao Huiying , Yu Weimiao , Wei Lai 
Published: April 2023

AbstractThe novel targeted therapeutics for hepatitis C virus (HCV) in last decade solved most of the clinical needs for this disease. However, despite antiviral therapies resulting in sustained virologic response (SVR), a challenge remains where the stage of liver fibrosis in some patients remains unchanged or even worsens, with a higher risk of cirrhosis, known as the irreversible group. In this study, we provided novel tissue level collagen structural insight into early prediction of irreversible cases via image based computational analysis with a paired data cohort (of pre- and post-SVR) following direct-acting-antiviral (DAA)-based treatment. Two Photon Excitation and Second Harmonic Generation microscopy was used to image paired biopsies from 57 HCV patients and a fully automated digital collagen profiling platform was developed. In total, 41 digital image-based features were profiled where four key features were discovered to be strongly associated with fibrosis reversibility. The data was validated for prognostic value by prototyping predictive models based on two selected features: Collagen Area Ratio and Collagen Fiber Straightness. We concluded that collagen aggregation pattern and collagen thickness are strong indicators of liver fibrosis reversibility. These findings provide the potential implications of collagen structural features from DAA-based treatment and paves the way for a more comprehensive early prediction of reversibility using pre-SVR biopsy samples to enhance timely medical interventions and therapeutic strategies. Our findings on DAA-based treatment further contribute to the understanding of underline governing mechanism and knowledge base of structural morphology in which the future non-invasive prediction solution can be built upon.
Development speed of sibling embryo positively reflects live birth rate after fresh day 3 embryo transfer
Authors: Wang Xue , Xiao Yaling , Zhou Yuanzheng , Wang Hanbi 
Published: April 2023

AbstractThe ability of sibling embryos to form blastocysts may reflect the developmental potential of the embryos that were transferred into the uterus. The purpose of the study was to investigate whether the development speed of sibling embryos positively reflects the live birth rate following fresh embryo transfer. We examined 1262 cycles of women who underwent day 3 (D3) cleavage embryo transfer in the Peking Union Medical College Hospital in 2015–2020, who were divided into three groups (D5, D5 + D6, and D6) according to blastocyst formation. The live birth rate in patients with blastocysts that formed on D6 was significantly lower than the other two groups (36.1%, 45.6% and 44.7%, P < 0.05). For women with blastocysts that formed on D6, the live birth rate was higher in those with more good quality blastocysts than poor-quality blastocysts (42.4 vs 32.3%, P < 0.05). Multiple regression analysis showed that the blastocyst development speed of sibling embryos was an independent factor affecting live birth after fresh embryo transfer (P < 0.05). We concluded that the blastocyst development speed of sibling embryos may reflect live birth rate following the transfer of D3 cleavage embryos.
Distinctive characteristics of prolonged standing low back pain developers’ and the associated risk factors: systematic review and meta-analysis
Authors: Khoshroo Fatemeh , Seidi Foad , Bayattork Mohammad , Moghadas-Tabrizi Yousef , Nelson-Wong Erika 
Published: April 2023

AbstractPain developers (PDs) are considered a pre-clinical low back pain (LBP) population at risk of clinical LBP development and thus exacting great social and economic costs. Therefore, it is necessary to comprehensively investigate their distinctive characteristics and the risk factors of standing-induced LBP based on which appropriate preventive measures can be planned. Scopus, Web of Science, and PubMed databases as well as Google Scholar and ProQuest were systematically searched from inception through 14 July 2022 using a combination of terms relevant to ‘standing’ and ‘LBP’. Studies with low risk of bias in English and Persian using a methodological quality scoring system were deemed eligible for inclusion if they were laboratory studies using prolonged standing duration greater than 42 min to classify adult PDs and non-pain developers (NPDs) without a history of LBP. PDs were compared with NPDs in demographics, biomechanical, and psychological outcomes. Weighted or standardized mean differences, and Hedge’s g were generated to determine the pooled effect sizes using STATA software version 17. 52 papers and theses involving 1070 participants (528 PDs and 542 NPDs) were eligible for inclusion in the systematic review 33 of which were used in meta-analyses. Significant differences between PDs and NPDs in terms of movement patterns, muscular, postural, psychological, structural, and anthropometric variables were evidenced. The following factors were found to have a statistically significant association with standing-induced LBP: lumbar fidgets (Hedge’s g − 0.72, 95% CI − 1.35 to − 0.08, P = 0.03), lumbar lordosis in participants over 25 years (Hedge’s g 2.75, 95% CI 1.89–3.61, P < 0.001), AHAbd test (WMD 0.7, 95% CI 0.36–1.05, P < 0.001), GMed co-activation (Hedge’s g 4.24, 95% CI 3.18–5.3, P < 0.001), and Pain Catastrophizing Scale (WMD 2.85, 95% CI 0.51–5.19, P = 0.02). Altered motor control displayed in AHAbd test and higher lumbar lordosis in individuals over 25 years seem to be probable risk factors for standing-induced LBP. In order to detect standing-induced LBP risk factors, future researchers should investigate the association of the reported distinctive characteristics to the standing-induced LBP and that whether they are manipulable through various interventions.
Silver nanoparticle toxicity on Artemia parthenogenetica nauplii hatched on axenic tryptic soy agar solid medium
Authors: Do Minh Anh , Dang Hoa Thi , Doan Nhinh Thi , Pham Hong Lam Thi , Tran Tuyet Anh , Le Van Cam Thi , Young Tim , Le Dung Viet 
Published: April 2023

AbstractThe use of gnobiotic brine shrimp (Artemia spp.) for ecotoxicology and bacteria-host interaction studies is common. However, requirements for axenic culture and matrix effects of seawater media can be an obstacle. Thus, we investigated the hatching ability of Artemia cysts on a novel sterile Tryptic Soy Agar (TSA) medium. Herein, we demonstrate for the first time that Artemia cysts can hatch on a solid medium without liquid, which offers practical advantages. We further optimized the culture conditions for temperature and salinity and assessed this culture system for toxicity screening of silver nanoparticles (AgNPs) across multiple biological endpoints. Results revealed that maxima hatching (90%) of embryos occurred at 28 °C and without addition of sodium chloride. When capsulated cysts were cultured on TSA solid medium Artemia were negatively impacted by AgNPs at 30–50 mgL−1 in terms of the embryo hatching ratio (47–51%), umbrella- to nauplii-stage transformation ratio (54–57%), and a reduction in nauplii-stage growth (60–85% of normal body length). At 50–100 mgL−1 AgNPs and higher, evidence of damage to lysosomal storage was recorded. At 500 mgL−1 AgNPs, development of the eye was inhibited and locomotory behavior impeded. Our study reveals that this new hatching method has applications in ecotoxicology studies and provides an efficient means to control axenic requirements to produce gnotobiotic brine shrimp.
Space vector pulse width modulation strategy for modular multilevel converters in power system
Authors: Lu Shengyang , Zhenhong Yan , Yongsheng Xiong , Jianhao Zhang , Tong Wang , Yu Zhu , Yuqiu Sui , Junyou Yang , Zhang Li , Wang Haixin 
Published: April 2023

AbstractAs a superior modulation strategy, space vector pulse width modulation (SVPWM) provides redundant voltage vectors and adjustable action time, which can achieve multi‐objective control of modular multilevel converter (MMC). An SVPWM strategy suitable for MMC is proposed. The strategy is divided into three stages. In the first stage, the appropriate voltage vector, the action time and the basic sub‐module (SM) input number are quickly calculated to ensure the output quality by equating MMC as a 2‐level inverter. In the second stage, a finite set of the circulating current suppression is established on the basis of the basic SM input number. The optimal SM input number is selected through rolling optimisation. In the last stage, according to the SM voltage sorting and the optimal SM input number, the optimal switching state is determined to realise the SM voltage balance control. The proposed control strategy simplifies the design of the control system, reduces the computational burden and can be easily extended to MMC with any SM number. The simulation and experimental results show that the proposed SVPWM strategy can reduce the circulating current and balance the SM capacitor voltage while ensuring the output quality.
Adaptive distributed demand side management with weighted dimension reduction for energy resource management in smart grid
Authors: Kafash Farkhad Masoud , Akbari Foroud Asghar 
Published: April 2023

AbstractDemand side management (DSM) consists of planning, executing, and controlling activities to reduce electricity consumption. By using demand response (DR), customers help reduce demand during peak times. Consumer participation in DSM depends on his behaviour. Consumer behaviour is determined by factors such as lifestyle, electricity price, electricity consumption tariff, contract type etc. Thus, factors affecting the consumer's behaviour should be considered in order to determine more accurately the amount of participation in DSM programs. This article presents a model for the optimal scheduling of distributed energy resources by taking into account factors related to consumer behaviour. To reduce the volume of the DR data while maintaining the main features, distributed principal component analysis (D_PCA) was used to reduce the volume of DR data. Also, by integrating this method with the accelerated hybrid alternating direction method of multipliers (AHADMM) algorithm, an adapted and accelerated method is achieved to realize the reliability and cyber security of the system. The case study was conducted on the IEEE 118 bus power system at different levels of demand, which verified proposed meta‐algorithm improved at least between 4 to 13 iterations of energy resource convergence speed compared to similar methods and while DR is also intended.
Polymer‐based nanocomposites in semiconductor packaging
Authors: Li Tengyu , Li Peng , Sun Rong , Yu Shuhui 
Published: April 2023

AbstractSemiconductor packaging materials play a critical role in the development of semiconductor devices. They not only provide reliable protection and support, but also contribute to the electrical connection between the chip and the external circuit. Among many choices of packaging materials, polymer‐based nanocomposites have become the mainstream candidate due to their low cost, easy processability, and tunable properties. Materials with low dielectric constant and dielectric loss, high glass transition temperature, fast thermal conductivity, suitable coefficient of thermal expansion, low viscosity, and good processability are commonly required in semiconductor packaging, yet most polymers do not meet these criteria. Therefore, modulation of the polymer matrix, introduction of suitable fillers, and modification of the filler surface are often effective approaches to enhance the performance of the composites. Here, the authors first review current research progresses of polymer‐based nanocomposites for five different types of packaging applications, namely moulding compounds, thermal interface materials, underfills, die attach materials, and substrates. The authors then present prospects of developing next‐generation polymer‐based nanocomposites for advanced semiconductor packaging and propose some suggestions to solve the existing challenges.
Development of enhanced direct torque control for surface‐mounted permanent magnet synchronous motor drive operation
Authors: Meesala Ravi Eswar Kodumur , Udumula Ramanjaneya Reddy , Nizami Tousif Khan , Hosseinpour Alireza 
Published: April 2023

AbstractDirect torque control (DTC) is one of the most prominent control techniques used by permanent magnet synchronous motor (PMSM) drives in industry applications. Nevertheless, the presence of hysteresis controllers and inaccurate voltage switching table in traditional DTC results in higher torque and flux ripple. This study proposes an enhanced DTC functioned Surface‐mounted PMSM (S‐PMSM) drive with mitigation of torque and flux ripple. The operation relies on generating the reference voltage vector (VV) in a stationary reference frame, which supports control of torque and flux without hysteresis controllers. The reference VV generation is simple and does not affect control robustness. The position of reference VV in a sector is used to build the voltage vector (VV) switching table. As a result, the application of nearest discrete VV to reference VV produces optimal torque and flux control. Moreover, redundant switching combinations of null VV are effectively used for possible minimization of switching frequency of two‐level voltage source inverter (VSI) supplied S‐PMSM drive. Therefore, proposed DTC gains improved S‐PMSM drive response along with switching frequency reduction. In dSPACE‐RTI 1104 platform, experimental response of S‐PMSM drive under various operating conditions have been depicted to highlight the proficiency of proposed DTC in comparison with existing DTC.
High-velocity CP2 stars in the Galactic halo
Authors: Faltová N. , Prišegen M. , Bernhard K. , Hümmerich S. , Paunzen E. 
Published: April 2023

Context. The second subclass of chemically peculiar stars, the CP2 stars, are early-type stars exhibiting anomalous abundances with variable line strengths possibly also accompanied by photometric variability that typically belong to the Galactic disk. However, a small fraction of these objects were recently found to be located far from the Galactic plane and are thought to belong to the Galactic halo, which is unexpected for this class of objects.
Aims. Our study investigates the halo membership of the proposed halo CP2 star candidates based on their velocities and Galactic orbits, to determine their points of origin. In addition, we searched for further halo CP2 star candidates using an as-yet-unpublished sample of CP stars.
Methods. Our analysis relied on the astrometry from the early third Gaia data release and radial velocities based on the spectroscopy from LAMOST and SDSS, which was also employed in spectral classification. The light variability of the confirmed CP2 stars in our sample was analyzed using data from the ZTF and ATLAS surveys.
Results. After filtering our initial sample using kinematic and spectroscopic criteria, we identified six CP2 stars with kinematical properties consistent with a halo membership. The orbits of these stars are in agreement with an origin in the Galactic disk where they were probably ejected through dynamical interactions or in the binary supernova scenario, making them the first runaway CP2 stars known.
Cosmo-tomography toward PKS 1830−211: Variability of the quasar and of its foreground molecular absorption monitored with ALMA
Authors: Muller S. , Martí-Vidal I. , Combes F. , Gérin M. , Beelen A. , Horellou C. , Guélin M. , Aalto S. , Black J. H. , van Kampen E. 
Published: April 2023

Context. Time variability of astronomical sources provides crude information on their typical size and on the implied physical mechanisms. PKS 1830−211 is a remarkable radio-bright lensed quasar with a foreground molecular absorber in the lens galaxy at z = 0.89. Small-scale morphological changes in the core–jet structure of the quasar – which is magnified by the lensing – result in a varying illumination of the absorber screen, which in turn causes variations in the absorption profile.
Aims. We aim to study the time variations of the system (the two main lensed images of the quasar and the two corresponding sightlines in the absorber) in order to obtain constraints on both the quasar activity and small-scale structures in the interstellar medium of the absorber.
Methods. We used ALMA to monitor the submillimeter continuum emission of PKS 1830−211, together with the absorption spectra of the H2O and CH molecules, with 17 visits spread over six months in 2016. Complementing this, we used available ALMA data to investigate changes in the system in the period 2012−2022.
Results. From the continuum data, we followed the evolution of the flux density, flux-density ratio, spectral index, and differential polarization between the two lensed images of the quasar; all quantities show significant variations related to the intrinsic activity of the quasar. We propose a simple parametric model of a core plus a ballistic plasmon to account for the continuum evolution, from which we constrain a time delay of 25 ± 3 days between main lensed images. The spectral lines reveal significant variations in the foreground absorption profile. A principal component analysis highlights apparent wavy time variations, possibly linked to the helical jet precession period of the quasar. From the deep averaged spectra towards the southwest image, we detect the absorption of the rare isotopolog 13CH and estimate an abundance ratio of 12CH/13CH ∼ 150. We also measure the oxygen isotopic ratios, 16O/18O = 65.3 ± 0.7 and 18O/17O = 11.5 ± 0.5 in the z = 0.89 absorber. Finally, we find a remarkable continuous shallow trough in the water absorption spanning a velocity interval of nearly 500 km s−1. This broad absorption could be the signature of an extra-planar molecular component.
Conclusions. All together, the system formed by the quasar PKS 1830−211 and its foreground lens–absorber acts as a powerful gravitational microscope, providing us with the possibility to dissect small-scale structures in both the ISM of the foreground absorber and the jet of the background quasar.