bluuebunny/crossref_metadata_2025_split huggingface dataset:
Selective Deletion of Methyl CpG Binding Protein 2 from Parvalbumin Interneurons in the Auditory Cortex Delays the Onset of Maternal Retrieval in Mice
Authors: Rupert Deborah D. , Pagliaro Alexa H. , Choe Jane , Shea Stephen D. 
Published: August 2023

Mutations inMECP2cause the neurodevelopmental disorder Rett syndrome.MECP2codes for methyl CpG binding protein 2 (MECP2), a transcriptional regulator that activates genetic programs for experience-dependent plasticity. Many neural and behavioral symptoms of Rett syndrome may result from dysregulated timing and thresholds for plasticity. As a model of adult plasticity, we examine changes to auditory cortex inhibitory circuits in female mice when they are first exposed to pups; this plasticity facilitates behavioral responses to pups emitting distress calls. Brainwide deletion ofMecp2alters expression of markers associated with GABAergic parvalbumin interneurons (PVins) and impairs the emergence of pup retrieval. We hypothesized that loss ofMecp2in PVins disproportionately contributes to the phenotype. Here, we find that deletion ofMecp2from PVins delayed the onset of maternal retrieval behavior and recapitulated the major molecular and neurophysiological features of brainwide deletion ofMecp2. We observed that when PVin-selective mutants were exposed to pups, auditory cortical expression of PVin markers increased relative to that in wild-type littermates. PVin-specific mutants also failed to show the inhibitory auditory cortex plasticity seen in wild-type mice on exposure to pups and their vocalizations. Finally, using an intersectional viral genetic strategy, we demonstrate that postdevelopmental loss ofMecp2in PVins of the auditory cortex is sufficient to delay onset of maternal retrieval. Our results support a model in which PVins play a central role in adult cortical plasticity and may be particularly impaired by loss ofMecp2.SIGNIFICANCE STATEMENTRett syndrome is a neurodevelopmental disorder that includes deficits in both communication and the ability to update brain connections and activity during learning (plasticity). This condition is caused by mutations in the geneMECP2. We use a maternal behavioral test in mice requiring both vocal perception and neural plasticity to probe the role ofMecp2in social and sensory learning.Mecp2is normally active in all brain cells, but here we remove it from a specific population (parvalbumin neurons). We find that this is sufficient to delay learned behavioral responses to pups and recreates many deficits seen in whole-brainMecp2deletion. Our findings suggest that parvalbumin neurons specifically are central to the consequences of loss ofMecp2activity and yield clues as to possible mechanisms by which Rett syndrome impairs brain function.
The EDC4‐XRN1 interaction controls P‐body dynamics to link mRNA decapping with decay
Authors: Brothers William R , Ali Farah , Kajjo Sam , Fabian Marc R 
Published: August 2023

AbstractDeadenylation‐dependent mRNA decapping and decay is the major cytoplasmic mRNA turnover pathway in eukaryotes. Many mRNA decapping and decay factors are associated with each other via protein–protein interaction motifs. For example, the decapping enzyme DCP2 and the 5'–3' exonuclease XRN1 interact with the enhancer of mRNA‐decapping protein 4 (EDC4), a large scaffold that has been reported to stimulate mRNA decapping. mRNA decapping and decay factors are also found in processing bodies (P‐bodies), evolutionarily conserved ribonucleoprotein granules that are often enriched with mRNAs targeted for decay, yet paradoxically are not required for mRNA decay to occur. Here, we show that disrupting the EDC4‐XRN1 interaction or altering their stoichiometry inhibits mRNA decapping, with microRNA‐targeted mRNAs being stabilized in a translationally repressed state. Importantly, we demonstrate that this concomitantly leads to larger P‐bodies that are responsible for preventing mRNA decapping. Finally, we demonstrate that P‐bodies support cell viability and prevent stress granule formation when XRN1 is limiting. Taken together, these data demonstrate that the interaction between XRN1 and EDC4 regulates P‐body dynamics to properly coordinate mRNA decapping with 5′–3′ decay in human cells.
Reducing Abuse and Neglect Recurrence Among Young Foster Children Reunified With Their Families
Authors: Constantino John N. , Buchanan Gretchen , Tandon Mini , Bader Carol , Jonson-Reid Melissa 
Published: August 2023

BACKGROUND AND OBJECTIVES
Child maltreatment (CM) is a recurrent adverse life event known to cause enduring psychiatric impairment throughout life. For young children in protective custody for a first episode of CM, specialized court-coordinated intervention to optimize reunification has shown promise for preventing CM recidivism, with case series documenting short-term successes.

METHODS
We tracked 10-year (Nov 2011–March 2022) court re-entry outcomes in a cohort of 272 young children, birth to six years, reunited with their families following placement in protective custody and court referral to the SYNCHRONY Project, a voluntary clinical service providing Incredible YearsTM parenting education, parental psychiatric care, and serial dyadic clinical evaluation to inform medical recommendations on safety for visitation and reunification. Re-entry was operationalized as rereferral to any Missouri Court and proportions compared with contemporaneous State and national data.

RESULTS
SYNCHRONY-enrolled/reunified children experienced frequencies of guardianship (22%) and reunification (46%), in keeping with Missouri averages. In these categories, 3.4% and 7.1% respectively were re-referred to the Court over the 10-year follow-up. In care as usual nationally for this age group, the re-referral proportions are 18% (OR 7.5, P &lt; .0001) and 35% (OR 6.1, P &lt; .0001) respectively. In care as usual in Missouri across all ages, the re-referral proportion is 16% (odds ratio [OR] 3.09, P &lt; .0001).

CONCLUSIONS
Judicious implementation of evidence-based parenting education, 2-generation psychiatric care, and clinical consultation were associated with marked reduction in court re-entry versus care-as-usual and warrant consideration in intervention standards for young children in foster care.
Acquisition and processing of word formation in German
Authors: Sommer-Lolei Sabine , Mattes Veronika , Korecky-Kröll Katharina , Dressler Wolfgang U. 
Published: August 2023

AbstractCognitive processing strategies can explain general word-formation preferences that influence the structures and their developments. They are based on simplicity, transparency, iconicity, salience, and frequency. We present and discuss evidence from our data on first language acquisition for how these cognitively based general preferences can explain the course of development of word formation and how they interact or compete. The analysis is based on the development of distributions of word formations in longitudinal data and panel data of child speech and their input from high and low socio-economic status families. In order to evaluate the productivity of a word-formation pattern in child speech, we applied the mini-paradigm criterion. Age-of-acquisition effects will be presented according to our own processing studies and to literature.
Characterisation and thermal improvement of adobe walls from earth-straw lightweight panels
Authors: Jové-Sandoval Félix , García-Baños Eva M. , Barbero-Barrera M. Mar 
Published: August 2023

AbstractSoil as a building material has great potential in terms of low embodied energy, although the great diversity of soils means that more research is needed to characterise them with precise values. In addition, their high thermal transmittance is one of the main drawbacks of earths, so the incorporation of agrowastes could imply a reduction of thermal conductivity without any harm to the embodied energy. Three types of agrowastes have been evaluated: long and short wheat straw fibres and a sawdust. These three fibres were mixed with barbotine to reduce the amount of solid material in the mixture. These panels were compared with the performance of a 20-cm-thick adobe wall. The thermal transmittance of the materials was analysed and the results showed that panel 2 with short wheat straw fibres performed well as a thermal insulation board with a thermal conductivity of λ = 0.05 W/mK.
Graphical abstract
Behavioural and anatomical observations of the amphibious snail Pirenella conica (Gastropoda: Potamididae)
Authors: Orstan Aydin 
Published: August 2023

The coastal snail Pirenella conica (Gastropoda: Potamididae) was observed and photographed in its mud flat habitat (Alaçati Bay, Karaburun Peninsula, Türkiye) and in the laboratory. The snails were amphibious; they moved about in damp sediment when the sea had receded and readily left the water in the laboratory to move on dry surfaces. The siphon, normally used for the intake of oxygenated water in submerged snails, remained open when snails were out of water, suggesting that they can also breathe air. Videos of snails taken from below explained the mechanics of their stop-and-go locomotion. Close-up photographs also revealed the presence of a pallial eye at the top of the siphonal canal. When a snail was partially buried in soft sediment, its pallial eye remained above the sediment. The pallial eye may orient the snail and help it detect potential dangers when its tentacular eyes are obstructed.
Bambúes nativos en la construcción de viviendas rurales: Bajareque en el México prehispánico y siglo XX
Authors: Ruiz-Sanchez Eduardo , García-Martínez Miguel Ángel , Heredia Espinoza Verenice Y. 
Published: August 2023

Antecedentes: El bajareque es una técnica de construcción en la que se utiliza un tejido hecho con bambú, cañas, varas, mimbres, agregados con diversos compuestos de tierra local, material vegetal y agua (lodo). En México, existe evidencia arqueológica y actual del uso del bajareque en la construcción de viviendas rurales. En el sitio arqueológico de Los Guachimontones, se ha documentado el uso del bajareque con una antigüedad de 2,400 a 1,500 años, Sin embargo, se desconoce la especie de bambú utilizada.
Preguntas y/o Hipótesis: 1) ¿Cuáles especies de bambú de México se han utilizado en la construcción de viviendas rurales con la técnica del bajareque? 2) ¿Cuál especie de bambú probablemente se utilizó en la construcción de viviendas con la técnica del bajareque en la zona arqueológica de Los Guachimontones, Jalisco?
Resultados: Nuestros resultados indican el uso de cinco especies de bambú (Guadua amplexifolia, G. paniculata, G. velutina, Otatea acuminata y O. fimbriata) en la construcción del bajareque. Es probable que la especie utilizada en la construcción de viviendas y estructuras cívico-ceremoniales en la zona arqueológica de Los Guachimontones sea Otatea acuminata.
Conclusiones: En este estudio, evidenciamos que en México se han utilizado cinco especies de bambú en la construcción del bajareque. De estas, tres pertenecen al género Guadua y dos al género Otatea. Es muy probable que en Los Guachimontones se haya utilizado Otatea acuminata en la construcción de sus viviendas con la técnica del bajareque.
ВВЕДЕНИЕ В КОНЦЕПТ ОБЩЕЙ ТЕОРИИ АВТОРСТВА
Authors: ФЕДОТОВ Михаил Александрович 
Published: August 2023

В статье обоснована возможность, целесообразность и актуальность разработки концепта общей теории авторства как метатеории современного права интеллектуальной собственности. Проанализированы — в целях выявления противоречий и лакун — основные положения существующего концепта права интеллектуальной собственности. Обоснована безосновательность приравнивания средств индивидуализации к результатам интеллектуальной деятельности, выявлены недостатки в действующем законодательстве об интеллектуальной собственности. Исследовано соотношение понятий «интеллектуальная собственность», «права интеллектуальной собственности», «интеллектуальные права».
Концепт общей теории авторства ставит в центр всей экосистемы интеллектуальной собственности именно автора — субъекта права, творца, а не результат его интеллектуальной деятельности или средство индивидуализации, то есть объект права, как это фактически делает концепт права интеллектуальной собственности. Смена «точки отсчета» неминуемо меняет всю систему логических связей внутри данной сферы, формируя несколько иную «картину интеллектуального мира».
Предлагаемый подход позволяет сформулировать основные понятия общей теории авторства, а именно «автор» и «объект интеллектуальной собственности», а также производные от них понятия, проанализировать основные свойства объектов интеллектуальной собственности, к числу которых относятся нематериальность, гетерогенность, человекоцентричность, креативность, герменевтичность.
Существующие системы правовой охраны объектов интеллектуальной собственности в неявной форме предполагают существование помимо автора еще одного субъекта, без которого не может состояться объект интеллектуальной собственности как объект «для других», — того, кто признает техническое решение — изобретением, упаковку — промышленным образцом, а текст, изображение или трехмерный предмет — произведением науки, литературы или искусства. В случае с объектами регистрационной системы таким субъектом выступает патентное ведомство, в «созидательской» системе — пользователь, потребитель. В статье обосновывается тезис о «соавторстве» пользователя в создании объекта интеллектуальной собственности как объекта «для других».
Case series of combination of carbon dioxide laser and topical 5-flourouracil for prevention of recurrence of keloid
Authors: Ittigi Vivekananda 
Published: August 2023

The treatment of keloid has been a challenge, and at times, frustrating because of the recurrence. Hence, it is essential to find treatment modality with least recurrence and good cosmetic results. This study showed the effect of topical 5-fluorouracil following carbon dioxide (CO2) laser excision on recurrence of keloid. Case series of Total 24 patients (20 females and 4 males) of age group 12-56 years having keloid of duration 1-8 years were included in this study. Lesions were present on ear lobes, shoulder, chest, leg. CO2 laser was used in continuous mode to excise the lesions and all patients advised topical 5-FU (5%) once daily application over the lesion in the night, once re-epithelization started, for 4 weeks. The patients were followed up initially at every week for 4 weeks then every 4 weeks for 24 weeks to evaluate the response of treatment. Of the 24 patients evaluated at 24 weeks, none (0%) showed any sign of recurrence. Out of 22 patients four (18.2%) patients complained of burning sensation/irritation. Three (13.6%) patients of erythema and erosion which cleared with temporary discontinuation of topical 5-FU and completed the 4 weeks of topical therapy. Three (13.6%) patients developed hypopigmentation. Though response of this combination is encouraging in prevention of recurrence of keloid, recurrence on long term follow up need to be observed.
Adjustments to Stimulation Frequency and Duration of STEP VEPs in Paediatric CVI
Authors: Mackay A M 
Published: August 2023

Recent research has demonstrated that the agreement between VEP and subjective VA is influenced by both technical and clinical factors [1-3]. In normal visual development, spatial resolution threshold is limited by the density of retinal bipolar cells [4] which initiate three distinct functional pathways; magnocellular, parvocellular, and koniocellular [5]. Ophthalmological conditions during development with pathology before the LGN and resulting in moderate or severe visual impairment [6] may preferentially preserve the magnocellular pathway making steady state VEPs the ideal assessment.
Issues and Concerns of Teachers Towards Modular Distance Learning Approach
Authors: Jayme Ronald , Maguate Guarin 
Published: August 2023

This research investigated the teachers’ issues and concerns towards modular distance learning approach. This study aimed to determine the level of issues and concerns encountered by teachers in the implementation of modular distance learning approach and the significant difference in the level of issues and concerns of teachers towards modular distance learning approach when grouped according to sex, number of years in service and number of related trainings. The study employed quantitative research, specifically a descriptive research design to determine the issues and concerns of fifty (50) elementary teachers of Cadiz District II in the Schools Division of Cadiz City. Total Purposive Enumeration sampling was used in selecting the respondents for the target samples. They were grouped according to the schools they are stationed at. The statistical tools used for the treatment of data were mean and standard deviation for problems 1 and 2, Independent t-test, and One-Way ANOVA used for problems 3 and 4. The results revealed that the teachers have high level of issues and concerns encountered towards modular distance learning approach. Moreover, the result of this investigation suggested that females have higher competencies on the level of issues and concerns of teachers towards modular distance approach than males. Therefore, the null hypothesis is rejected as a significant difference exists in the issues and concerns of teachers towards Modular Distance Learning approach when grouped according to sex. On the other hand, the null hypothesis is accepted as no significant difference exists in the issues and concerns of teachers towards Modular Distance Learning approach when grouped according to number of years in service and number of related trainings.
Removal of pruned vine biomass (PVB) from vineyards – Examining the impact of not incorporating PVB into vineyard soils
Authors: Pike Benjamin , Muhlack Richard , Cavagnaro Timothy , Collins Cassandra 
Published: August 2023

The wine industry worldwide faces increasing challenges to achieve sustainable levels of carbon emission mitigation. This study seeks to establish the feasibility of harvesting winter pruned vineyard biomass (PVB) for potential use in carbon footprint reduction as a renewable biofuel for energy production. Of particular interest is the role PVB plays as a carbon source in vineyard soils and what effect annual removal might have on soil carbon. An investigation was carried out in the Coombe vineyard, Waite Campus (University of Adelaide), Australia. Vines are grown in a Vertic clay loam soil with well-managed mid-row swards in a temperate zone. A comparison was undertaken of two mid-row treatments after 13 years of consistent management: 1) the deliberate exclusion of PVB from every third row, and 2) in the remaining rows PVB was incorporated at an average of 3.4 and 5.5 t/ha in two 0.25 ha blocks containing Shiraz and Semillon respectively. In both 0-10 cm and 10-30 cm soil core sample depths, combined soil carbon % values in the desired range of 1.80 to 3.50 were not significantly different between treatments or cultivars and yielded an estimated 42 t/ha of soil carbon. Other key physical and chemical values were likewise not significantly different between treatments. Results suggest that in a temperate zone vineyard, managed such as the one used in this study, there is no long-term negative impact on soil carbon sequestration through removing PVB. This implies that growers could confidently harvest PVB for use in biofuel production.
ANALISIS PEMBELAJARAN KURIKULUM MERDEKA DI SDN PLOSOKIDUL
Authors: Wyandha Brillita , Purnama Erninda Diknes , Primaridha Monita Rizky , Damariswara Rian 
Published: August 2023

Kurikulum adalah seperangkat rencana untuk mencapai tujuan pendidikan tertentu. Meskipun kurikulum sering diubah, Kurikulum merupakan transformasi pendidikan melalui kebijakan Merdeka Belajar dan Kampus Merdeka untuk mewujudkan SDM Unggul Indonesia dengan Profil Pelajar Pancasila. Siswa yang memiliki kemampuan kognitif yang baik dalam ujian tertulis tidak selalu mampu mengaplikasikan pengetahuannya dengan baik dalam menghadapi masalah di kehidupan sehari-hari. Tujuan dari proses belajar sangat terkait dengan evaluasi hasil belajar. Tujuan artikel ini adalah untuk menjelaskan penilaian kurikulum pembelajaran mandiri di sekolah dasar. Menurut kami Kurikulum Merdeka ini dirancang oleh pemerintah dengan tujuan untuk menyempurnakan kurikulum sebelumnya. Perubahan ini berjalan di sesuaikan dengan perkembangan zaman dan mulai tampak perubahan, isi dari Kurikulum Merdeka ini hampir mirip dengan kurikulum 2006 ktsp, namun di kurikulum merdeka ini menekan adanya hasil pembelajaran proyek yang dipublikasikan.
Kata Kunci : Kurikulum Merdeka, Guru, Siswa, Pendidikan
Congenital Upper-Limb Differences
Authors: Shah Ayush , Bohn Deborah C. , Van Heest Ann E. , Hu Caroline H. 
Published: August 2023

➤ The Oberg-Manske-Tonkin (OMT) classification of congenital hand and upper-limb anomalies continues to be refined as our understanding of the genetic and embryonic etiology of limb anomalies improves.➤ We have conducted an evaluation of graft and graftless techniques for syndactyly reconstruction; strengths and drawbacks exist for each technique.➤ Treatment for radial longitudinal deficiency remains controversial; however, radialization has shown promise in early follow-up for severe deformities.➤ Recent emphasis on psychosocial aspects of care has demonstrated that children with congenital upper-limb differences demonstrate good peer relationships and marked adaptability.
Burocracia e Identidade Profissional de Terceirizados
Authors: Costa de Faria Jéssica , Ventola Marra Adriana , Pereira de Souza Mariana Mayumi , Santos Pinheiro Alexandre 
Published: August 2023

Objetivo da pesquisa: compreender a influência da burocracia na identidade profissional dos indivíduos terceirizados da Universidade Federal de Viçosa – campus Florestal (UFV/CAF).
Enquadramento teórico: O eixo teórico buscou aprofundar na administração pública e seus processos burocráticos, na terceirização e sua origem e no fenômeno da identidade.
Metodologia: Estudo de caso qualitativo descritivo realizado com uma triangulação de dados: entrevistas semiestruturadas com os indivíduos terceirizados; análise documental; e observação, analisados através da Análise de Discurso da corrente francesa pecheutiana.
Resultados: Foram obtidos três percursos semânticos: a identidade dos terceirizados; as características burocráticas; e os mecanismos da terceirização. O primeiro trouxe três temas, que são as personagens do discurso; a trajetória profissional; e as semelhanças e diferenças existentes entre funcionários terceirizados e servidores. O segundo trata dos procedimentos burocráticos da terceirização. E o terceiro trata das inseguranças causadas pelos mecanismos de controle da terceirização. Como conclusões, a UFV/CAF, a cidade de Florestal e a empresa terceirizada foram as personagens de maior destaque nas identidades. Foi constatado que os funcionários vivem sob constante insegurança profissional. Por fim, foi relatada a identidade de exclusão dos terceirizados, principalmente devido à diferença de tratamento e de direitos e deveres à qual são submetidos.
Originalidade: O estudo é inovador no sentido de analisar a identidade sob a ótica da burocracia de funcionários terceirizados inseridos no setor público.
Contribuições teóricas e práticas: A principal contribuição deste trabalho está relacionada à complementação dos estudos sobre terceirização e identidade no setor público, com análise a ser realizada observando elementos da burocracia, ainda muito presente nos órgãos do governo. O estudo pode igualmente contribuir para uma generalização dos estudos organizacionais brasileiros acerca de identidade profissional de sujeitos terceirizados, tendo em vista a alta utilização desta modalidade de contratação no país.