bluuebunny/crossref_metadata_2025_split huggingface dataset:
An exploration of distinguishing subjective cognitive decline and mild cognitive impairment based on resting-state prefrontal functional connectivity assessed by functional near-infrared spectroscopy
Authors: Pu Zhengping , Huang Hongna , Li Man , Li Hongyan , Shen Xiaoyan , Wu Qingfeng , Ni Qin , Lin Yong , Cui Donghong 
Published: January 2025

PurposeFunctional near-infrared spectroscopy (fNIRS) has shown feasibility in evaluating cognitive function and brain functional connectivity (FC). Therefore, this fNIRS study aimed to develop a screening method for subjective cognitive decline (SCD) and mild cognitive impairment (MCI) based on resting-state prefrontal FC and neuropsychological tests via machine learning.MethodsFunctional connectivity data measured by fNIRS were collected from 55 normal controls (NCs), 80 SCD individuals, and 111 MCI individuals. Differences in FC were analyzed among the groups. FC strength and neuropsychological test scores were extracted as features to build classification and predictive models through machine learning. Model performance was assessed based on accuracy, specificity, sensitivity, and area under the curve (AUC) with 95% confidence interval (CI) values.ResultsStatistical analysis revealed a trend toward compensatory enhanced prefrontal FC in SCD and MCI individuals. The models showed a satisfactory ability to differentiate among the three groups, especially those employing linear discriminant analysis, logistic regression, and support vector machine. Accuracies of 94.9% for MCI vs. NC, 79.4% for MCI vs. SCD, and 77.0% for SCD vs. NC were achieved, and the highest AUC values were 97.5% (95% CI: 95.0%–100.0%) for MCI vs. NC, 83.7% (95% CI: 77.5%–89.8%) for MCI vs. SCD, and 80.6% (95% CI: 72.7%–88.4%) for SCD vs. NC.ConclusionThe developed screening method based on resting-state prefrontal FC measured by fNIRS and machine learning may help predict early-stage cognitive impairment.
The efficacy and safety of remimazolam besylate, ciprofol, and propofol during hysteroscopy
Authors: Shan Weifeng , Gao Shuying , Ai Mengting , Lan Haiyan , Duan Gongchen , Dong Xiaoli , Xu Qiaomin , Wu Yini , Wu Jimin 
Published: January 2025

ObjectiveRemimazolam besylate and Ciprofol are newer sedatives used in minor surgeries. Propofol is a classic drug mainly used for short surgeries. This trial was conducted to compare the efficacy and safety of remimazolam besylate, ciprofol, and propofol during hysteroscopic surgeries.MethodsPatients undergoing hysteroscopy were randomly assigned to receive remimazolam besylate (Group R), ciprofol (Group C), or propofol (Group P). A total of 194 patients were assessed for eligibility. One patient in Group P was excluded because the operation had timed out of 60 min. Patients all in Group R、Group C and Group P received an induction dose of 0.2 mg/kg remimazolam besylate、0.4 mg/kg ciprofol、2.0 mg/kg propofol seperately over 30 s. A corresponding dosage of 1 mg/kg/h、0.6–1.2 mg/kg/h and 3.0–6.0 mg/kg/h was given by continuous intravenous infusion to maintain a BIS of 40–60 till the end of the surgery. The incidence rates of body movement, respiratory depression, and adverse effects were compared among the groups.ResultsThe incidence of injection pain was much higher in Group P (64.1%) than that in Group R (3.4%) and Group C (3.2%, both P &lt; 0.001). The onset time was significantly shorter in Group P than that in Group R and Group C (both P &lt; 0.01). The awakening time (MOAA/S score = 3) was longest in Group R, followed by Groups C and Group P (P &lt; 0.01). The time to complete recovery (MOAA/S score = 5) has no significantly difference between Group C and Group P, whereas the onset time was significantly shorter in Group R (P &lt; 0.01). The number of body movements was significantly higher in Group R than that in Group C and Group P (P &lt; 0.01). The incidence of hypotension was significantly lower in Group R than that in Group C and Group P (both P &lt; 0.01). The rate of respiratory inhibition was significantly lower in Group R and Group C than that in Group P (both P &lt; 0.05).ConclusionConsidering jointly the safety and efficacy, ciprofol seems to be the best choice for sedation.
Anti-inflammatory and antioxidant properties of oleuropein in human keratinocytes characterized by bottom-up proteomics
Authors: Li Huifang , Deng Ni , Yang Jiayi , Zhao Yang , Jin Xiaoxuan , Cai Ang , Seeram Navindra P. , Ma Hang , Li Dongli , Yang Huilan , Liu Chang 
Published: January 2025

Oleuropein is a phenolic compound commonly found in cosmetic ingredients including olive leaves and jasmine flowers with various skin-beneficial effects. Here, we evaluated oleuropein’s anti-inflammatory and antioxidant activities in human skin cells. In a cell-based inflammasome model with human monocytes (THP-1 cells), oleuropein (12–200 µM) reduced proinflammatory cytokine interleukin (IL)-6 by 38.8%–45.5%, respectively. Oleuropein (50 and 100 µM) also alleviated oxidative stress in keratinocytes (HaCaT cells) by reducing H2O2-induced cell death by 6.4% and 9.2%, respectively. Additionally, biological evaluations revealed that oleuropein’s antioxidant effects were attributed to its mitigation of reactive oxygen species in HaCaT cells. Furthermore, a multiplexed gene assay identified IL-1β and thioredoxin-interacting proteins as potential molecular targets involved in oleuropein’s protective effects in HaCaT cells. This was supported by findings from several cellular assays showing that oleuropein reduced the level of IL-1β and inhibited the activity of caspase-1/IL-1 converting enzyme, as well as ameliorated pyroptosis in HaCaT cells. Moreover, a bottom-up proteomics study was conducted to explore potential molecular targets and signaling pathways involved in oleuropein’s antioxidant activities. Taken together, findings from this study expand the understanding of oleuropein’s skin protective effects against oxidative and inflammatory stresses, which support that oleuropein is a promising natural cosmeceutical for skincare applications.
Anti-colorectal cancer effect of total minor ginsenosides produced by lactobacilli transformation of major ginsenosides by inducing apoptosis and regulating gut microbiota
Authors: Shen Yunjiao , Gao Yansong , Yang Ge , Zhao Zijian , Zhao Yujuan , Gao Lei , Li Shengyu 
Published: January 2025

ObjectiveMinor ginsenosides have demonstrated promising anticancer effects in previous reports. Total minor ginsenosides (TMG) were obtained through the fermentation of major ginsenosides with Lactiplantibacillus plantarum, and potential anticancer effects of TMGs on the mouse colon cancer cell line CT26.WT, in vitro and in vivo, were investigated.Materials and MethodsWe employed the Cell Counting Kit-8 (CCK-8), TdT-mediated dUTP nick end labeling (TUNEL), and Western blot analysis in vitro to explore the anti-proliferative and pro-apoptotic functions of TMG in CT26.WT cells. In vivo, a xenograft model was established by subcutaneously injecting mice with CT26.WT cells and administering a dose of 100 mg/kg/day TMG to the tumor-bearing mice. The level of apoptosis and expression of various proteins in the tumor tissues were detected by immunohistochemistry and Western blot. High-throughput 16S rRNA sequencing was used to determine the alterations in the gut microbiota.ResultsIn vitro studies demonstrated that TMG significantly inhibited proliferation and promoted apoptosis in CT26.WT cells. Interestingly, TMG induced apoptosis in CT26.WT cells by affecting the Bax/Bcl-2/caspase-3 pathway. Furthermore, the result of the transplanted tumor model indicated that TMG substantially enhanced the activities of Bax and caspase-3, reduced the activity of Bcl-2, and suppressed the expression of Raf/MEK/ERK protein levels. Fecal analysis revealed that TMG reconstructed the gut microbiota in colorectal cancer-affected mice by augmenting the abundance of the advantageous bacterium Lactobacillus and decreasing the abundance of the harmful bacterium Proteus.ConclusionTMG can exhibit potent anti-colorectal cancer effects through diverse apoptotic mechanisms, with their mode of action closely related to the regulation of gut microbiota.
Application of additive manufacturing for the adaptive design of ultrasound phantoms
Authors: Zalka Lukas , Köhrer Johannes , Songsaeng Chatsuda , Homolka Peter , Kollmann Christian , Hummel Johann , Figl Michael 
Published: January 2025

IntroductionThe image formation process of conventional pulse-echo Ultrasound mainly uses the backscattered amplitude and assumes constant attenuation and speed of sound in the penetrated media. Thus, many commercially available ultrasound imaging phantoms use only a limited choice of materials with simple geometric shapes. Part of today’s research in ultrasound is to gain more information on the acoustic properties of the object imaged. These advanced imaging and reconstruction procedures require more complicated phantom designs that contain different materials with precisely designable acoustic properties for validation and quality assurance (QA).MethodsTo fabricate such phantoms, we produced molds for casting ultrasound phantoms using additive manufacturing. Phantom materials used were based on agar and polyvinyl alcohol. To adapt the speed of sound glycerol was added to the mixtures. As glycerol diffuses out of the phantom material, polluting the surrounding water, we designed a watertight sample holder. The effect of the freeze-thaw cycles (FTCs) on the acoustic properties of the polyvinyl alcohol (PVA)-based phantoms was also investigated. Speed of sound and attenuation were determined for both phantoms materials, and Shore hardness measured for the PVA-based phantoms.ResultsShore hardness of the PVA phantoms increased by up to 79% of the initial value with increasing number of freeze-thaw cycles, but showed a saturation after 5 FTCs. However, the number of FTCs had only a small effect on the speed of sound and attenuation, as the sound speed increased slightly from 1,530.14 m/s to 1,558.53 m/s, (1.86%) and the attenuation exhibited only an increase of 6.75%. In contrast, differences of around 100 m/s in the speed of sound in the PVA phantoms (from 1,558.53 to 1,662.27 m/s), as well as in the agar-based phantoms (from 1,501.74 to 1,609.36 m/s) could be achieved by adding glycerol, making these materials appropriate candidates for the design and fabrication of US phantoms with defined sections and details with different speed of sound and attenuation. The use of the sample holder showed only an influence of 0.63% on the measured speed of sound.Discussion3D printed molds led to an improved manufacturing process as well as a free choice of the shape of the phantoms. A sample holder could prevent contamination of the water with no significant differences in the measured speed of sound.
Miniature-inverted-repeat transposable elements contribute to phenotypic variation regulation of rice induced by space environment
Authors: Chen Lishan , Yang Qing , Zhang Yan , Sun Yeqing 
Published: January 2025

IntroductionRice samples exposed to the space environment have generated diverse phenotypic variations. Miniature-inverted-repeat transposable elements (MITEs), often found adjacent to genes, play a significant role in regulating the plant genome. Herein, the contribution of MITEs in regulating space-mutagenic phenotypes was explored.MethodsThe space-mutagenic phenotype changes in the F3 to F5 generations of three space-mutagenic lines from the rice varieties Dongnong423 (DN423) and Dongnong (DN416) were meticulously traced. Rice leaves samples at the heading stage from three space-mutagenic lines were subjected to high coverage whole-genome bisulfite sequencing and whole-genome sequencing. These analyses were conducted to investigate the effects of MITEs related epigenetic and genetic variations on space-mutagenic phenotypes.Results and discussionStudies have indicated that MITEs within gene regulatory regions might contribute to the formation and differentiation of space-mutagenic phenotypes. The space environment has been shown to induce the transposable elements insertion polymorphisms of MITEs (MITEs-TIPs), with a notable preference for insertion near genes involved in stress response and phenotype regulation. The space-induced MITEs-TIPs contributed to the formation of space-mutagenic phenotype by modulating the expression of gene near the insertion site. This study underscored the pivotal role of MITEs in modulating plant phenotypic variation induced by the space environment, as well as the transgenerational stability of these phenotypic variants.
Information, social networks and emotions: fear and anger towards Pedro Sánchez 2019–2021
Authors: Rivera José Manuel , Lagares Nieves , Jaráiz Erika , Pereira María 
Published: January 2025

IntroductionThe objective of this research is to determine the relationship between the use citizens make of social networks to learn about politics and the emotions expressed towards political leaders, taking as a case study the current Prime Minister of Spain Pedro Sánchez.MethodsA quantitative methodological approach was used in this longitudinal study. This approach proposes both a descriptive and multivariate analysis of data from three databases.ResultsThe analysis of results shows important differences between consuming political information on social networks and not doing so in terms of the type of negative emotions (anger and fear) generated towards Pedro Sánchez. Connecting these findings with previous cognitive approaches led us to conclude that, while fear encourages citizens to seek alternative information, when they seek it through social networks the expression of anger increases.DiscussionIn this sense, preliminary results suggest that fear towards Pedro Sánchez becomes anger when information is proactively sought in social networks.
Assessing self-determined motivation for drinking alcohol via the Comprehensive Relative Autonomy Index for Drinking
Authors: Courtney Jimikaye Beck , Russell Michael A. , Conroy David E. 
Published: January 2025

IntroductionSelf-Determination Theory (SDT) examines human motivation in multiple domains; however, the only existing measure assessing SDT-informed behavioral regulations for drinking focuses on responsible drinker behaviors, rather than drinking per se, which is important given the alignment between SDT and harm reduction approaches to alcohol use. The aim of this study was to test the structural validity of the SDT-informed Comprehensive Relative Autonomy Index for Drinking (CRAI-Drinking) among college students.MethodsParticipants included two convenience samples with a total of 630 adult drinkers (Mage = 21.5, 55% female, 88% undergraduates). Participants rated drinking behavioral regulations on the 24 original CRAI-Drinking items on a 5-point Likert Scale. Multi-dimensional scaling analyses and factor analyses were used to investigate the underlying autonomy continuum and factor structure of the CRAI-Drinking.ResultsIn Sample 1 (n = 274), multi-dimensional scaling analyses confirmed that CRAI-Drinking item and subscale order aligned with SDT's autonomy continuum. Confirmatory factor analyses supported a five factor, 19-item model of the CRAI-Drinking with factors for intrinsic, identified, positive introjected, external, and amotivation regulations (Cronbach's α: 0.68–0.85). In Sample 2 (n = 356), a confirmatory factor analysis confirmed that the 19-item model fit was comparable to Sample 1.DiscussionThis study provides evidence for the structural validity of CRAI-Drinking scores for assessing SDT-based behavioral regulations for drinking in adults.
Empowering young athletes: the influence of autonomy-supportive coaching on resilience, optimism, and development
Authors: Zhang Na , Du Geng , Tao Tao 
Published: January 2025

IntroductionThe present study investigates how autonomy-supportive coaching style influences youth athlete development through psychological resilience and dispositional optimism. Despite growing interest in factors that contribute to athlete development, gaps remain in understanding how coaching approaches interact with psychological traits to foster youth athletes’ growth. This study addresses these gaps by proposing a serial mediation model in which autonomy-supportive coaching indirectly enhances athlete development through resilience and optimism.MethodsData were collected from 325 youth athletes and their coaches across training facilities and schools in China, and analyzed using structural equation modeling in SmartPLS.ResultsResults indicate that autonomy-supportive coaching style significantly increases psychological resilience, which in turn boosts dispositional optimism, positively impacting athlete development. Both resilience and optimism serially mediate the link between coaching style and athlete growth.DiscussionThese findings emphasize the importance of autonomy-supportive coaching in creating psychologically supportive environments that foster resilience, optimism, and developmental pathways in youth sports.
Predicting online shopping addiction: a decision tree model analysis
Authors: Wan Xueli , Zeng Jie , Zhang Ling 
Published: January 2025

BackgroundOnline shopping addiction has been identified as a detrimental behavioral pattern, necessitating the development of effective mitigation strategies.ObjectiveThis study aims to elucidate the psychological mechanisms underlying online shopping addiction through constructing and analyzing a C5.0 decision tree model, with the ultimate goal of facilitating more efficient intervention methods.MethodologyA comprehensive survey was conducted among 457 university students in Sichuan, China, utilizing validated psychometric instruments, including the Online shopping addiction Scale, College Academic Self-Efficacy Scale, College Students’ Sense of Life Meaning Scale, Negative Emotion Scale, Social Anxiety Scale, Sense of Place Scale, and Tuckman Procrastination Scale.ResultsThe predictive model demonstrated an accuracy of 79.45%, identifying six key factors predictive of online shopping addiction: academic procrastination (49.0%), sense of place (26.1%), social anxiety (10.1%), college students’ sense of life meaning (7.0%), negative emotions (7.0%), and college academic self-efficacy (0.9%).ConclusionThis pioneering study in online shopping addictiononline shopping addiction prediction offers valuable tools and research support for identifying and understanding this behavioral addiction, potentially informing future intervention strategies and research directions. This study provides research support for improving people’s understanding and management of behavioral addictions and promoting healthier online shopping habits.
The efficacy of internet-based cognitive behavior therapy for psychological health and quality of life among breast cancer patients: a systematic review and meta-analysis
Authors: Lin Tang , Ping Yin , Jing Cai Ming , Xu Zhi Xiao , Ping Zhu 
Published: January 2025

ObjectiveTo systematically investigate the effect of Internet-based cognitive-behavioral therapy (ICBT) on depression, anxiety, fatigue and quality of life (QOL) in patients with breast cancer (BC).MethodsA systematic review with meta-analysis and qualitative evidence synthesis was performed. Ten databases, including PubMed, Web of Science, EMBASE, the Cochrane Library, CINAHL, JBI Chinese Biomedical database (CBM), China National Knowledge Infrastructure (CNKI), VIP, and Wanfang, were searched from the start till August 2023. Published studies in English or Chinese were eligible for randomized and clinical controlled trials determining the efficacy of ICBT among BC survivors. The quality of the evidence was evaluated at the study level and the outcome level.ResultsIn total, 11 clinical trials on 1,307 patients with BC (ICBT: 671, control: 636) were systematically reviewed. We found that ICBT is effective in alleviating psychological distress in BC survivors, and the quality of all studies was moderate. The meta-analysis indicated that ICBT affected primary outcomes of anxiety (standardized mean difference [SMD] = −0.71, 95% confidence interval [CI]: −1.19, −0.24, p &lt; 0.0001), depression (SMD = −0.67, 95% CI: −1.07, −0.27, p &lt; 0.0001), fatigue (SMD = −1.23, 95% CI: −2.37, −0.08, p &lt; 0.0001) and QOL (SMD = 0.79, 95% CI: 0.21, 1.37, p &lt; 0.00001).ConclusionThis meta-analysis indicates that ICBT, as a type of psychosocial rehabilitation, can mitigate the incidence of depression, anxiety, and fatigue and improve the quality of life among patients with BC. Nevertheless, the effect is not distinct, and multi-centered randomized controlled trials with larger cohorts are warranted to verify the effectiveness of ICBT.
Understanding the behavioral intentions of MaaS during public health events
Authors: Luo Hang , Ma Shoufeng , Tian Junfang , Dong Hongming 
Published: January 2025

IntroductionMobility as a Service (MaaS) integrates various modes of transportation, provides personalized travel services for travelers, and improves the efficiency of traditional travel modes. To examine the mechanisms underlying the impact of sudden public health events on the behavioral intentions to use MaaS and provide theoretical support for the sustainable development of MaaS, this research investigates the Beijing MaaS program as a case.MethodsA total of 630 questionnaires were collected. Theoretical model, sourced from the Unified Theory of Acceptance and Use of Technology (UTAUT) model, is employed to elucidate the influence of six variables—performance expectancy, effort expectancy, social influence, ambiguity tolerance, perceived health threat, and policy cognition—on the behavioral intentions of MaaS.ResultsThe results show that three variables from the UTAUT positively impact behavioral intention and that there is a significant mediating effect of policy cognition on the relationship between these variables and the intention to use. Travelers with a high level of ambiguity tolerance are more inclined to use MaaS, while the perceived health threat reduces the intentions.DiscussionMultigroup analysis revealed differences in effort expectancy, ambiguity Toleance, and perceived health threat among the various groups. The research findings may provide theoretical guidance and empirical evidence for the promotion strategies of MaaS and for the formulation of related policies.