bluuebunny/crossref_metadata_2025_split huggingface dataset:
RDInfratech: An Online Repository of Species and Research for Mt. Hamiguitan Range
Authors: Laureano Lanie , Simo  Wilkin , Nanual Bernadette , Sacay Ar-Jay , Dongiapon Dony 
Published: June 2023

The study aimed to develop an online repository for wildlife species and research conducted in Mt. Hamiguitan Range (MHR) that will contain MHR research outputs for public information and education. The study used agile development in planning, creating, deploying, and testing the online portal. CodeIgniter PHP framework was utilized in the development and MySQL as the database and web hosting services for its deployment. The online portal provides administrator functions such as managing records of species, researches, events, articles and article comments as well as users. It features easy site navigation for the general public in viewing and searching the information about different species, researches and articles. An adopted questionnaire was used for the usability evaluation of the online repository. Based on the results, the users perceived that the online repository was able to meet the user satisfaction in terms of system, information, and interface quality. The user feedback became the basis for the system’s continuous improvement.
Proceso de atención de enfermería para un retorno seguro a las escuelas posterior al covid-19 -análisis de caso comunitario
Authors: Morales Rojas Marco Esteban , Aké Canul Didier Francisco , Cohuo Cob Sheila Mariela , Balam Gómez Maricela , Tun González Dallany Trinidad 
Published: June 2023

La COVID-19 provocó el cierre de las escuelas, y trasladó las actividades a los entornos virtuales por casi dos años. Posteriormente, los gobiernos otorgaron a las instituciones educativas, planes de retorno seguro a las actividades escolares para mejorar una transición a la presencialidad de la comunidad escolar y mantener a un mínimo los casos nuevos de la COVID-19. El profesional de enfermería, a través del Proceso de Atención de Enfermería (PAE), posee las herramientas y conocimientos necesarios para operativizar estos lineamientos e implementarlos de forma efectiva en las comunidades escolares. Objetivo: Implementar el PAE para facilitar el retorno seguro a las actividades escolares en una escuela primaria de México. Metodología: Estudio de caso comunitario con PAE, implementado en una escuela primaria pública de México. Para la valoración se utilizaron técnicas cualitativas y de participación comunitaria (entrevistas, cartografía social, etc) y para el proceso diagnóstico, resultados e intervenciones se utilizó la taxonomía NANDA 2021-2023, Clasificación de Resultados NOC y Clasificación de Intervenciones NIC. Resultados: Se trabajó en torno a un diagnóstico, un resultado y dos intervenciones sobre la participación comunitaria en programas educativos y de comunicación en salud, así como la disminución de las conductas de riesgo para la salud en la comunidad. Conclusiones: El PAE permitió mejorar las conductas promotoras de la salud en torno al uso de cubrebocas, sana distancia y lavado de manos en la comunidad. Se elaboraron materiales de comunicación en salud como técnica de refuerzo de los hábitos aprendidos.
Nivel de información sobre factores de riesgo de Infarto agudo de miocardio en pacientes ambulatorios, Corrientes año 2021 .
Authors: Morales Ivanna Paola , Campos Rodríguez Daiana Belén , Sánchez Lucia Ines 
Published: June 2023

Objetivo: Determinar el nivel de información sobre factores de riesgo de Infarto agudo de miocardio en los pacientes ambulatorios que asisten a una institución de salud de la provincia de Corrientes año 2021. Metodología: Estudio cuantitativo descriptivo, transversal y observacional. Muestra obtenida mediante muestreo probabilístico aleatorio simple compuesta por 108 pacientes que asistieron a los consultorios de Diabetes, Presurometría y Hospital de Día. Se aplicó un cuestionario validado mediante una prueba piloto. Variables: edad, sexo, nivel de instrucción, Nivel de información sobre alimentación, hábitos nocivos, actividad física y preguntas generales. Los resultados fueron volcados a una matriz diseñada en programa Excel. Resultados: La población en estudio presento una mediana de edad de 43, moda 39 y predomino del sexo masculino 56%, sobre el femenino 44%, en el nivel de instrucción prevaleció el secundario completo 19% seguido de primario incompleto 15%. Abordando los niveles de información sobre factores de riesgo de Infarto agudo de miocardio predominaron los niveles altos en todas las variables trabajadas, obteniendo un nivel general de información alto del 82%, se apreció en la alimentación 65%, hábitos nocivos 70%, aspectos generales un 86% y actividad física 48%. Conclusión: Esta investigación remarca la importancia de la educación permanente y en etapas tempranas sobre los factores de riesgo de Infarto Agudo de Miocardio. La población en estudio presento un nivel alto de información. No obstante, la educación debe fomentarse para llegar al 37% restante que obtuvo niveles inferiores.
Administración de Oxigenoterapia de Alto Flujo en pacientes pediátricos del Hospital de Niños Santísima Trinidad.
Authors: Salvático Estela , Chávez Nilda Cecilia , Oliva Olga del Valle , Prado Solange 
Published: June 2023

La manera de proveer oxígeno ha sido una idea en permanente evolución que ha gatillado en los médicos la inquietud de implementar distintos dispositivos de soporte, desde la cánula nasal, la máscara de reinhalación y bajo flujo, hasta la presión continua en la vía aérea (CPAP) y la ventilación no invasiva (VNI). Recientemente se ha insertado entre ambos extremos mencionados un nuevo dispositivo que provee oxígeno a alto flujo. El objetivo del presente trabajo fue describir aspectos clínicos y técnicos en la administración de Oxigenoterapia de Alto Flujo (OAF) en pacientes pediátricos del Hospital de Niños de la Santísima Trinidad, en el servicio de UEPE (Unidad estabilización pediátrica en emergencia) 2017 y SIP (sala de internación pediátrica) 500 2018, 2019, en el periodo estival. Se realizó un Estudio descriptivo transversal, retrospectivo. El universo fueron los pacientes pediátricos que recibieron OAF en el Hospital de Niños Santísima Trinidad, en el servicio de UEPE del 2017 y SIP 500 2018, 2019 en el periodo estival. Se utilizó como instrumento la tabla de volcado de datos. Los principales resultados demuestran que se asistieron un total de 697 pacientes. La edad prevalente fue de menores de 6 meses, con un promedio del 60%. Los niños que requerían este tratamiento, en su gran mayoría ingresaban por diagnóstico de bronquiolitis, seguido de BOR (bronquitis obstructiva recurrente).En relación al escore de tal modificado al ingreso, podemos observar que en el sector de UEPE la media es de 8, mientras que la SIP 500 es de 7. En referente al recurso material, existen varios sistemas de OAF. No hay estudios que demuestren la superioridad de un sistema sobre otro.Por último, se observó que el haber implementado esta técnica en la institución, se logró evitar en gran numero la escalada ventilatoria máxima requerida, ya que en el servicio de UEPE la evolución fue 65% la OAF, mientras que en la SIP 500 en el 2018 fue 72%y en el 2019 fue 79%. Por lo que podemos establecer que la OAF logra una mejoría clínica a través de su impacto en el síndrome funcional respiratorio, así como en el score de Tal modificado en los niños y permite un tratamiento de estos pacientes en salas de internado general, con mínimos efectos adversos, disminuyendo el ingreso a cuidados intensivos.
Neurociencia y Derechos Humanos: rama del bioderecho para fundamentar el derecho
Authors: Vargas Mendoza Mauricio Ivan , R. Manrique Molina Filiberto Eduardo , Yañez Nuñez Lorena Esmeralda 
Published: June 2023

The modern philosophy that supports the law, established that the logical reason is the criterion of truth, before it, the Spanish author Xavier Zubiri, built the mature metaphysics from the nascent neuroscience of his time and quantum mechanics, his philosophy. serves as the foundation of the Ibero-American theory, on the other hand, neuroscience as a branch of knowledge was born in 1960, when scientists from various branches discovered the need for multidisciplinarity to understand human behavior from the central nervous system, in this research, it is exposed the law, the philosophical revolution of mature metaphysics, the recent birth of neuroscience as a discipline of knowledge, the advances in neuroscience in the last 20 years, the state of the question of the neuroscience-law relationship and the main discussions regarding Her future. It is placed at the end, the reflection on promoting foundations from neuroscience towards a future right, a subject that has been little discussed in the legal field
La filosofía moderna que sustenta el derecho, estableció que la razón lógica es el criterio de verdad, ante ella, el autor español Xavier Zubiri, construyo la metafísica madura a partir de la neurociencia naciente de su tiempo y la mecánica cuántica, su filosofía sirve como fundamento de la teoría iberoamericana, por otro lado, la neurociencia como rama del conocimiento nació en 1960, al descubrir científicos de diversas ramas la necesidad de multidisciplinariedad para conocer el comportamiento humano a partir del sistema nervioso central, en esta investigación, se expone el derecho, la revolución filosófica de la metafísica madura, el nacimiento reciente la neurociencia como disciplina del conocimiento, los avances de la neurociencia en los últimos 20 años, el estado de la cuestión de la relación neurociencia-derecho y las principales discusiones en cuanto a su futuro. Se coloca al final, la reflexión sobre propiciar fundamentos desde la neurociencia hacía un derecho futuro, tema que ha sido poco discutido en el ámbito jurídico
Effect of Dexmedetomidine on Posttraumatic Stress Disorder in Patients Undergoing Emergency Trauma Surgery
Authors: Yu Youjia , Li Yan , Han Dan , Gong Chuhao , Wang Liwei , Li Beiping , Yao Rui , Zhu Yangzi 
Published: June 2023

ImportancePosttraumatic stress disorder (PTSD) is common in people who have experienced trauma, especially those hospitalized for surgery. Dexmedetomidine may reduce or reverse the early consolidation and formation of conditioned fear memory and prevent the occurrence of postoperative PTSD.ObjectiveTo evaluate the effects of intraoperative and postoperative low-dose intravenous pumping dexmedetomidine on PTSD among patients with trauma undergoing emergency surgery.Design, Setting, and ParticipantsThis double-blind, randomized clinical trial was conducted from January 22 to October 20, 2022, with follow-up 1 month postoperatively, in patients with trauma undergoing emergency surgery at 4 hospital centers in Jiangsu Province, China. A total of 477 participants were screened. The observers were blinded to patient groupings, particularly for subjective measurements.InterventionsDexmedetomidine or placebo (normal saline) was administered at a maintenance dose of 0.1 μg/kg hourly from the start of anesthesia until the end of surgery and at the same rate after surgery from 9 pm to 7 am on days 1 to 3.Main Outcomes and MeasuresThe primary outcome was the difference in the incidence of PTSD 1 month after surgery in the 2 groups. This outcome was assessed with the Clinician-Administered PTSD Scale for Diagnostic and Statistical Manual of Mental Disorders (Fifth Edition) (CAPS-5). The secondary outcomes were the pain score within 48 hours and 1 month postoperatively; incidence of postoperative delirium, nausea, and pruritus; subjective sleep quality; anxiety; and occurrence of adverse events.ResultsA total of 310 patients (154 in the normal saline group and 156 in the dexmedetomidine group) were included in the modified intention-to-treat analysis (mean [SD] age, 40.2 [10.3] years; 179 men [57.7%]). The incidence of PTSD was significantly lower in the dexmedetomidine group than in the control group 1 month postoperatively (14.1% vs 24.0%; P = .03). The participants in the dexmedetomidine group had a significantly lower CAPS-5 score than those in the control group (17.3 [5.3] vs 18.9 [6.6]; mean difference, 1.65; 95% CI, 0.31-2.99; P = .02). After adjusting for potential confounders, the patients in the dexmedetomidine group were less likely to develop PTSD than those in the control group 1 month postoperatively (adjusted odds ratio, 0.51; 95% CI, 0.27-0.94; P = .03).Conclusions and RelevanceIn this randomized clinical trial, the administration of intraoperative and postoperative dexmedetomidine reduced the incidence of PTSD among patients with trauma. The findings of this trial support the use of dexmedetomidine in emergency trauma surgery.Trial RegistrationChinese Clinical Trial Register Identifier: ChiCTR2200056162
Association of Open Reduction and Internal Fixation With Volar Locking Plate for Distal Radius Fractures With Patient-Reported Outcomes in Older Adults
Authors: Jayaram Mayank , Wood Shannon M. , Kane Robert L. , Yang Lan-Yan , Chung Kevin C. 
Published: June 2023

ImportanceRandomized clinical trials (RCTs) and meta-analyses have reported inconsistent conclusions regarding optimal distal radius fracture (DRF) treatment in older adults and are limited due to the inclusion of cohort studies with small sample sizes. A network meta-analysis (NMA) addresses these limitations by only synthesizing direct and indirect evidence from RCTs and may clarify optimal DRF treatment in older adults.ObjectiveTo examine DRF treatment results in optimal short-term and intermediate-term patient-reported outcomes.Data SourcesSearches of MEDLINE, Embase, Scopus, and Cochrane Central Register of Controlled Trials were conducted for RCTs that investigated DRF treatment outcomes in older adults between January 1, 2000, and January 1, 2022.Study SelectionRandomized clinical trials including patients with a mean age of 50 years or older that compared the following DRF treatments were eligible for inclusion: casting, open reduction and internal fixation with volar lock plating (ORIF), external fixation, percutaneous pinning, and nail fixation.Data Extraction and SynthesisTwo reviewers independently completed all data extraction. An NMA aggregated all direct and indirect evidence among DRF treatments. Treatments were ranked by surface under the cumulative ranking curve score. Data are reported as standard mean differences (SMDs) and 95% CIs.Main Outcomes and MeasuresThe primary outcome was short-term (≤3 months) and intermediate-term (&amp;gt;3 months to 1 year) Disabilities of the Arm, Shoulder and Hand (DASH) questionnaire scores. Secondary outcomes included Patient-Rated Wrist Evaluation (PRWE) scores and 1-year complication rates.ResultsIn this NMA, 23 RCTs consisting of 3054 participants (2495 women [81.7%]) with a mean (SD) age of 66 (7.8) years were included. At 3 months, DASH scores were significantly lower for nail fixation (SMD, −18.28; 95% CI, −29.93 to −6.63) and ORIF (SMD, −9.28; 95% CI, −13.90 to −4.66) compared with casting. The PRWE scores were also significantly lower for ORIF (SMD, −9.55; 95% CI, −15.31 to −3.79) at 3 months. In the intermediate term, ORIF was associated with lowered DASH (SMD, −3.35; 95% CI, −5.90 to −0.80) and PRWE (SMD, −2.90; 95% CI, −4.86 to −0.94) scores. One-year complication rates were comparable among all treatments.Conclusions and RelevanceThe findings of this NMA suggest that ORIF may be associated with clinically significant improvements in short-term recovery compared with casting for multiple patient-reported outcomes measures with no increase in 1-year complication rates. Shared decision-making with patients may be useful to identify patient preferences regarding recovery to determine optimal treatment.
Experiences of US Clinicians Contending With Health Care Resource Scarcity During the COVID-19 Pandemic, December 2020 to December 2021
Authors: Butler Catherine R. , Wightman Aaron G. , Taylor Janelle S. , Hick John L. , O’Hare Ann M. 
Published: June 2023

ImportanceThe second year of the COVID-19 pandemic saw periods of dire health care resource limitations in the US, sometimes prompting official declarations of crisis, but little is known about how these conditions were experienced by frontline clinicians.ObjectiveTo describe the experiences of US clinicians practicing under conditions of extreme resource limitation during the second year of the pandemic.Design, Setting, and ParticipantsThis qualitative inductive thematic analysis was based on interviews with physicians and nurses providing direct patient care at US health care institutions during the COVID-19 pandemic. Interviews were conducted between December 28, 2020, and December 9, 2021.ExposureCrisis conditions as reflected by official state declarations and/or media reports.Main Outcomes and MeasuresClinicians’ experiences as obtained through interviews.ResultsInterviews with 23 clinicians (21 physicians and 2 nurses) who were practicing in California, Idaho, Minnesota, or Texas were included. Of the 23 total participants, 21 responded to a background survey to assess participant demographics; among these individuals, the mean (SD) age was 49 (7.3) years, 12 (57.1%) were men, and 18 (85.7%) self-identified as White. Three themes emerged in qualitative analysis. The first theme describes isolation. Clinicians had a limited view on what was happening outside their immediate practice setting and perceived a disconnect between official messaging about crisis conditions and their own experience. In the absence of overarching system-level support, responsibility for making challenging decisions about how to adapt practices and allocate resources often fell to frontline clinicians. The second theme describes in-the-moment decision-making. Formal crisis declarations did little to guide how resources were allocated in clinical practice. Clinicians adapted practice by drawing on their clinical judgment but described feeling ill equipped to handle some of the operationally and ethically complex situations that fell to them. The third theme describes waning motivation. As the pandemic persisted, the strong sense of mission, duty, and purpose that had fueled extraordinary efforts earlier in the pandemic was eroded by unsatisfying clinical roles, misalignment between clinicians’ own values and institutional goals, more distant relationships with patients, and moral distress.Conclusions and RelevanceThe findings of this qualitative study suggest that institutional plans to protect frontline clinicians from the responsibility for allocating scarce resources may be unworkable, especially in a state of chronic crisis. Efforts are needed to directly integrate frontline clinicians into institutional emergency responses and support them in ways that reflect the complex and dynamic realities of health care resource limitation.
DNA‐Based Materials Inspired by Natural Extracellular DNA
Authors: Qin Zi‐xuan , Wang Chen‐yu , Zhang Jiang‐shan , Wang Zhang‐yi , Wei Yu , Li Yu‐tao , Dai Shi‐qi , Tay Franklin R , Niu Li‐na 
Published: June 2023

AbstractThe advent of biotechnology has expedited the understanding of the biochemistry of deoxyribonucleic acids (DNA). In the past, DNA are thought to be present only in cell nucleus as bearers of the genetic code. With the identification of extracellular DNA in circulating body fluids, DNA are now utilized, at least experimentally, for diagnosis and treatment of diseases. Extracellular DNA of host origin trigger immune responses, and are closely linked to autoimmune disease, cancer‐related inflammation, bacteria adhesion and thrombosis. Recent advancements in DNA nanotechnology have led to the development of a series of DNA‐based materials for treating diseases because of their structural programmability. Current discussions on biosafety and immunogenicity of artificial DNA materials are insufficient. This issue severely restricts the clinical translation of these novel biotechnologies. The present review attempts to bridge the gap between natural extracellular DNA and their derivatives, DNA‐based materials. The pathological attributes of endogenous extracellular DNA motivate the design of targeting DNA materials. In addition, the fate of exogenous DNA in the host inspires the optimization of DNA materials in reducing immune rejection. These bioinspired strategies provide the blueprint for utilizing DNA materials in the management of diseases that are currently challenging to diagnose or treat.
Highly Adhesive Epidermal Sensors with Superior Water‐Interference‐Resistance for Aquatic Applications
Authors: Wang Shuai , Li Shuo , Wang Haomin , Lu Haojie , Zhu Mengjia , Wu Xun‐En , Liang Huarun , Liang Xiaoping , Zhang Yingying 
Published: June 2023

AbstractGrand challenges exist in the fabrication of robust skin electronics that are resistant to water interference, which can play vital roles in healthcare and lifesaving in activities such as showering, surfing, and swift water rescue. Particularly, dynamic water impingement is very destructive to skin electronics by causing device–skin delamination and sensing malfunctions. Herein, an anemone‐inspired self‐adhesive epidermal sensor with superior ability to resist water interference in various aquatic environments is developed. The epidermal sensor consists of a strain sensing layer composed of interconnected graphene flakes wrapped in ultrathin Ecoflex and a self‐adhesive layer composed of semi‐crosslinked polydimethylsiloxane, which is named as an adhesive graphene encapsulated in Ecoflex (a‐G@E) sensor. The a‐G@E sensor can conformally and stably attach on the skin under the synergy effect of the ultrathin thickness and the self‐adhesive layer. Remarkably, it can maintain a highly stable device–skin interface even under extreme aquatic conditions such as intense water impingement (up to 4 m s−1). As examples, this study demonstrates its applications in transmitting information, controlling robotics underwater, and tracking swimming modes of a fish. It is believed that the a‐G@E sensor can play a unique role in health‐care, sports‐monitoring, and human–machine interactions, especially for aquatic scenarios.
Designed Multifunctional Spider Silk Enabled by Genetically Encoded Click Chemistry
Authors: Jiang Bojing , Tan Sin Yen , Fang Shiyu , Feng Xiaohan , Park Byung Min , Fok Hong Kiu Francis , Yang Zhongguang , Wang Ri , Kou Songzi , Wu Angela Ruohao , Sun Fei 
Published: June 2023

AbstractSpider silk is recognized for its exceptional mechanical properties and biocompatibility, making it a versatile platform for developing functional materials. In this study, a modular functionalization strategy for recombinant spider silk is presented using SpyTag/SpyCatcher chemistry, a prototype of genetically encoded click chemistry. The approach involves AlphaFold2‐aided design of SpyTagged spider silk coupled with bacterial expression and biomimetic spinning, enabling the decoration of silk with various SpyCatcher‐fusion motifs, such as fluorescent proteins, enzymes, and cell‐binding ligands. The silk threads can be coated with a silica layer using silicatein, an enzyme for silicification, resulting in a hybrid inorganic–organic 1D material. The threads installed with RGD or laminin cell‐binding ligands lead to enhanced endothelial cell attachment and proliferation. These findings demonstrate a straightforward yet powerful approach to 1D protein materials.