bluuebunny/crossref_metadata_2025_split huggingface dataset:
INVESTIGAÇÃO CIENTÍFICA PARA O 1º ANO DO ENSINO FUNDAMENTAL: UMA ARTICULAÇÃO ENTRE FALAS E REPRESENTAÇÕES GRÁFICAS DOS ALUNOS
Authors: Coelho Flores Jeane , Puntel Robson Luiz 
Published: April 2023

O artigo em questão escrito por Tatiana Schneider Vieira de Moraes e Anna Maria Pessoa de Carvalho foi baseado no estudo de discentes ingressantes no primeiro ano do ensino fundamental de uma escola de Ribeirão Preto, São Paulo. De acordo com as autoras, os estudantes podem ser iniciados no ensino de ciências, desde pequenos, através da representação gráfica ou desenho e de discussões científicas com seus colegas e professor. Ambos são formas de comunicação do discente e que podem levar a novos conceitos e um maior engajamento na alfabetização científica auxiliando no desenvolvimento de habilidades.Estão elencados no presente, um apanhado de autores: uns, focam na análise de crianças maiores, outros, em estudos referentes a crianças da educação infantil, enquanto que o segmento pertencente aos anos iniciais, não é apontado na pesquisa. Mesmo assim, para vários autores citados, incluindo Piaget e Inhelder (1993) independente da idade em que o discente se encontra, a representação gráfica torna-se um meio de construir e interpretar significados. Já a construção de argumentos em sala de aula, com atividades investigativas é enfatizada por Sasseron e Carvalho (2008, 2011). Então a fala e o desenho são formas de linguagem que levam o estudante ao mundo da ciência. O trabalho apresenta um enfoque qualitativo com estudo de caso, através da observação de um grupo específico, utilizando uma sequência de Ensino Investigativa sendo organizada em portfólios individuais que possibilitaram a análise e discussão de dados através de categorias para assim, poderem ser tecidas as considerações finais.Trabalhar com crianças de anos iniciais para a descoberta da ciência não é fácil para muitos docentes, mas como a atualização e o repensar das práticas fazem parte da rotina do professor, esse trabalho torna-se possível. Penso que a oralidade e o desenho, além de auxiliarem na iniciação científica, podem expressar emoções, revelar segredos, contar histórias e construir idéias essenciais para a aprendizagem significativa. Esse estudo será útil a todas as pessoas que precisam entender um pouco mais sobre o universo da criança e a importância de sua inserção no mundo da ciência, através de atividades interessantes e significativas.
ANTT® standardisation facilitates new efficiencies with a novel partially-sterile Standard-ANTT PIVC Pack
Authors: Rowley Stephen , Clare Simon 
Published: April 2023

Introduction: The widespread adoption of the ANTT®Clinical Practice Framework as a single standard for aseptic technique, has highlighted that many clinical procedures do not require a sterile procedure pack to be performed safely and aseptically. This study explores the utilisation of a partially-sterile procedure pack that is specifically tailored to Standard-ANTT. Methods: A prospective project improvement evaluation, using a non-paired sample (pre: n=41; post: n=33) of emergency department staff in an NHS hospital. Staff were evaluated performing peripheral intravenous cannulations (PIVC) using Standard-ANTT and the B. Braun Standard-ANTT peripheral cannulation pack. Findings: Significant improvements were observed in practice following the implementation of the pack and training in Standard-ANTT, including: Key-Part protection significantly improved (pre: n=28, 68.2%; post: n=33, 100%), and reduction in the Key-Site being touched after disinfection (pre: n=17; 41.4%; post n=5; 15.1%). Conclusions: In conjunction with appropriate education and training, this study provides proof of concept that due to the widespread use of the ANTT Clinical Practice Framework as a single standard aseptic technique, procedure packs that are specifically tailored to Standard-ANTT, can help to promote best practice and improve efficiencies. Definitions: Partially-sterile procedure pack – all items required to be sterile remain in their individual blister wrapper. The final assembled pack itself is not then subjected to a further round of sterilisation as it is not needed. Sterile procedure pack – often contains a mixture of non-sterile and sterile items that have been stripped from their individual blister wrapper requiring the sterilisation of the final assembled pack.
3  bit terahertz coder based on a graphene composite metasurface
Authors: Wang Hong , Hu Fangrong , Gong Yumin , Jiang Mingzhu , Zhang Longhui , Zeng Lizhen 
Published: April 2023

Terahertz (THz) frequency coders are indispensable components of broadband wireless communication systems of the future. However, the coding of THz wave at multiple frequencies is still a challenge. In this work, a 3 bit THz coder based on a graphene composite metasurface is proposed and simulated using a full-wave electromagnetic simulation software. The unit cell of the device consists of three graphene-embedded split-ring-resonators (SRRs), i.e., SRR1, SRR2, and SRR3. The device has three transmission peaks modulated by external voltages of V1, V2, and V3. The central frequency of the peak generated by SRR1 locates at 0.864 THz and its maximum modulation depth is 79.6%. The second peak generated by SRR2 locates at 1.161 THz and has a maximum modulation depth of 87%. The third peak at 1.541 THz is produced by SRR3 and has a maximum modulation depth of 85.3%. More importantly, the device can be used as a 3 bit coder, and the codes of 111, 110, 101, 011, 100, 010, 001, and 000 are successfully realized by controlling the voltages of V1, V2 and V3. The proposed device has potential applications in next-generation broadband wireless communications.
Social Network Analysis of the Schistosomiasis control program in two local government areas in Oyo state, Nigeria: Insights for NTD elimination plans
Authors: Onasanya Adeola , van Engelen Jo , Oladunni Opeyemi , Oladepo Oladimeji , Diehl Jan Carel 
Published: April 2023

Background
Schistosomiasis is one of the neglected tropical diseases targeted for elimination by 2030. Achieving disease elimination requires collaboration between stakeholders, country ownership and the involvement of community-level stakeholders. The state of stakeholder relationship determines the ease and timeliness of meeting disease elimination targets. Mapping stakeholder relationships is critical for assessing gaps in the schistosomiasis control program implementation, and providing a roadmap for improved stakeholder cohesion. The study aimed to measure the cohesiveness of the contact, collaboration and resource-sharing networks, across 2 local government areas in Oyo state, Nigeria.

Materials and methods
This study used a Network Representative design for Social Network Analysis (SNA). The study was conducted within Oyo state, Nigeria using 2 Local Government Areas (LGAs): Ibadan North (urban) and Akinyele (rural). Stakeholders were identified using a link-tracing approach. Data was collected using Qualtrics software from stakeholders across the state, local government, healthcare, academia, and non-governmental organizations. Data was analysed using Gephi software for network cohesion across the three networks.

Results
The social network analysis revealed high clustering and low density across the three networks implying low cohesion across multiple stakeholder categories. The contact and collaborative networks were the most active with the lowest level of cohesion seen in the resource-sharing network. Stakeholders were more active in the rural LGA than the urban, and stakeholders within the organized governance and public health system were the dominant actors in the schistosomiasis control program.

Conclusion
The low cohesion, high clustering and low network density among stakeholders within the schistosomiasis control program should be addressed in other to drive innovation and meet the WHO schistosomiasis elimination target.
Translation, cross-cultural adaptation, and psychometric evaluation of the Persian (Farsi) version of the QoLAF (quality of life in patients with anal fistula) questionnaire
Authors: Keramati Mohammad Reza , Yazd Seyed Mostafa Meshkati , Omidi Mostafa , Keshvari Amir , Shahriarirad Sepehr , Shahriarirad Reza , Ahmadi-Tafti Seyed Mohsen , Behboudi Behnam , Kazemeini Alireza , Sahebi Leyla , Fazeli Mohammad Sadegh 
Published: April 2023

Introduction
The effective treatment of anal fistulas almost always requires surgical intervention, which could be accompanied by post-operative complications, and affect the quality of life of patients. This study aimed to cross-culturally adapt the Persian version of the Quality of Life in patients with Anal Fistula questionnaire and evaluate its validity and reliability.

Materials and methods
Sixty patients with a mean age of 44 years ranging from 21 to 72 years entered the study. Forty-seven participants were men, and thirteen were women. After performing a scientific translation of the questionnaire based on Beaton’s guidelines for cross-cultural adaptation and after extensive reviews by experts and specialists, the final version of the questionnaire was obtained. Then, 60 questionnaires (100%) were filled out by the participants (n = 60) and retrieved during a 7 to 21-day period. Data were collected and analyzed. Finally, according to the obtained data, the validity and reliability of the questionnaire were calculated.

Results
Cross-cultural adaptation of the translated questionnaire was verified by the expert committee. The results showed perfect internal consistency (Cronbach alpha = 0.842), and external consistency (intraclass correlation coefficient = 0.800; P<0.001). Spearman correlation coefficient between test and retest was reported to be 0.980 (P-value <0.01), confirming the temporal stability of the translated questionnaire. The interrater reliability based on Cohen’s kappa coefficient also demonstrated a perfect degree of agreement between two peer variables (Kappa = 0.889; P<0.001).

Conclusion
The Persian translation of the Quality of Life in patients with the Anal Fistula questionnaire was proven to be valid and reliable for the evaluation of the QoL of patients with anal fistula.
VA’s implementation of universal screening and evaluation for the suicide risk identification program in November 2020 –Implications for Veterans with prior mental health needs
Authors: Gujral Kritee , Bahraini Nazanin , Brenner Lisa A. , Van Campen James , Zulman Donna M. , Illarmo Samantha , Wagner Todd H. 
Published: April 2023

Importance
United States Veterans are at higher risk for suicide than non-Veterans. Veterans in rural areas are at higher risk than their urban counterparts. The coronavirus pandemic intensified risk factors for suicide, especially in rural areas.

Objective
To examine associations between Veterans Health Administration’s (VA’s) universal suicide risk screening, implemented November 2020, and likelihood of Veterans being screened, and receiving follow-up evaluations, as well as post-screening suicidal behavior among patients who used VA mental health services in 2019.

Methods
VA’s Suicide Risk Identification Strategy (Risk ID), implemented October 2018, is a national, standardized process for suicide risk screening and evaluation. In November 2020, VA expanded Risk ID, requiring annual universal suicide screening. As such, we are evaluating outcomes of interest before and after the start of the policy among Veterans who had ≥1 VA mental health care visit in 2019 (n = 1,654,180; rural n = 485,592, urban n = 1,168,588). Regression-adjusted outcomes were compared 6 months pre-universal screening and 6, 12 and 13 months post-universal screening implementation.

Measures
Item-9 on the Patient Health Questionnaire (I-9, VA’s historic suicide screener), Columbia- Suicide Severity Risk Scale (C-SSRS) Screener, VA’s Comprehensive Suicide Risk Evaluation (CSRE), and Suicide Behavior and Overdose Report (SBOR).

Results
12 months post-universal screening implementation, 1.3 million Veterans (80% of the study cohort) were screened or evaluated for suicide risk, with 91% the sub-cohort who had at least one mental health visit in the 12 months post-universal screening implementation period were screened or evaluated. At least 20% of the study cohort was screened outside of mental health care settings. Among Veterans with positive screens, 80% received follow-up CSREs. Covariate-adjusted models indicated that an additional 89,160 Veterans were screened per month via the C-SSRS and an additional 30,106 Veterans/month screened via either C-SSRS or I-9 post-universal screening implementation. Compared to their urban counterparts, 7,720 additional rural Veterans/month were screened via the C-SSRS and 9,226 additional rural Veterans/month were screened via either the C-SSRS or I-9.

Conclusion
VA’s universal screening requirement via VA’s Risk ID program increased screening for suicide risk among Veterans with mental health care needs. A universal approach to screening may be particularly advantageous for rural Veterans, who are typically at higher risk for suicide but have fewer interactions with the health care system, particularly within specialty care settings, due to higher barriers to accessing care. Insights from this program offer valuable insights for health systems nationwide.
Support measures for the next of kin who has experienced the unexpected loss of a family member to HIV/AIDS
Authors: Hlophe Siphesihle Delani , Jooste Karien 
Published: April 2023

Background
Passing of a close family member is one of the foremost traumatic occasions in a person’s life. The way in which this misfortune unfolds, shifts from individual to individual, and depend on how close you were with the deceased. It was unclear on what were the support measures provided to youth after the loss a family member to HIV/AIDS.

Aim
The aim of this article is to understand the support measures for the youth following the unexpected loss of a family member to HIV/AIDS.

Setting
Khayelitsha, Western Cape province, South Africa.

Method
A descriptive phenomenological design was followed, with an accessible population of youth who lost a family member to HIV/AIDS. Individual semi-structured interviews were conducted with 11 purposively selected participants after obtaining written informed consent. The sessions held with an interview schedule, did not take longer than 45 minutes to conduct until data saturation was reached. A digital recorder was used and field notes held. Open coding followed after transcribing interviews.

Results
Youths did not know how to manage themselves as a result of a lack of therapeutic sessions, which could provide emotional support and help them with their healing process.

Conclusion
Support measures for the next of kin were needed. Grieving influenced the emotions of an individual who experienced the burden of not having someone to speak to about their feelings.

Contribution
The context-based information in this study addresses the important of support measures to be provided or implemented for the next of kin after they had lost a family member.
Experiments on physical ablation of long bone using microwave ablation; defining optimal settings using ex- and in-vivo experiments
Authors: Nijland Hendricus , Zhu Jinwen , Kwee Thomas , Hao Dingjun , Jutte Paul 
Published: April 2023

Background
Improved survival of cancer patients leads to more skeletal metastatic lesions that need local therapies for tumor control and pain relief. Not all tumors are radiosensitive and alternative therapies are direly needed. Microwave ablation (MWA) is a technique for minimally invasive local tumor control by physical ablation. In soft tissue local temperature ablation is more common, but studies on bone tissue are limited. To ensure safe and effective treatment, studies on local tumor ablation in bone are needed.

Method
Microwave ablation was performed on sheep bone, for both in- and ex-vivo settings. Both a slow-cooking MWA protocol (gradually increasing wattage in the first two minutes of ablation) and a fast-cooking protocol (no warm-up period) were used. Heat distribution through the bone during ablation was determined by measuring temperature at 10- and 15mm from the ablation probe (= needle). Ablation size after procedure was measured using nitro-BT staining.

Results
In-vivo ablations led to up to six times larger halos than ex-vivo with the same settings. Within both ex- and in-vivo experiments, no differences in halo size or temperature were found for different wattage levels (65W vs 80W). Compared to a fast cooking protocol, a two-minute slow cooking protocol led to increased temperatures and larger halos. Temperatures at 10- and 15mm distance from the needle no longer increased after six minutes. Halo sizes kept increasing over time without an evident plateau.

Conclusion
Microwave ablation is technically effective for creating cell death in (sheep) long bone. It is recommended to start ablations with a slow-cooking period, gradually increasing the surrounding tissue temperature in two minutes from 40 to 90°C. Ex-vivo results cannot simply be translated to in-vivo.
Biomarker expression and survival in patients with non-small cell lung cancer receiving adjuvant chemotherapy in Denmark
Authors: Dalvi Tapashi , Nørgaard Mette , Fryzek Jon P. , Movva Naimisha , Pedersen Lars , Pham Hansen Hanh , Walker Jill , Midha Anita , Shire Norah , Boothman Anne-Marie , Rigas James , Mellemgaard Anders , Rasmussen Torben R. , Hamilton-Dutoit Stephen , Cronin-Fenton Deirdre 
Published: April 2023

Introduction
Programmed cell death ligand-1 (PD-L1) expression may help identify patients with non-small cell lung cancer (NSCLC) who would benefit from immunotherapy. We assessed PD-L1 expression, and epidermal growth factor receptor (EGFR) and V-Ki-Ras2 Kirsten rat sarcoma (KRAS) mutations in NSCLC patients receiving adjuvant chemotherapy.

Methods
Data for stage IB/II/IIIA NSCLC patients (diagnosed: 2001–2012) were retrieved from Danish population-based registries. Tumor tissue samples were tested for PD-L1 expression using VENTANA PD-L1 (SP263) Assay in tumor cells (TC) at ≥25% cutoff and immune cells (IC) at ≥1% and ≥25% cutoffs. KRAS and EGFR mutations were tested using PCR-based assays. Follow-up began 120 days after diagnosis until death/emigration/January 1, 2015, whichever came first. Using Cox proportional hazard regression, hazard ratios (HRs) were computed for overall survival (OS) for each biomarker, adjusting for age, sex, histology, comorbidities, and tissue specimen age.

Results
Among 391 patients identified, 40.4% had stage IIIA disease, 49.9% stage II, and 8.7% stage IB. PD-L1-TC was observed in 38% of patients, EGFR mutations in 4%, and KRAS mutations in 29%. KRAS mutations were more frequent among patients with PD-L1 TC≥25% versus TC<25% (37% versus 24%). OS was not associated with PD-L1 TC≥25% versus TC<25% (stage II: adjusted HR = 1.15 [95% confidence interval: 0.66–2.01]; stage IIIA: 0.72 [0.44–1.19]). No significant association was observed with OS and PD-L1-IC ≥1% and ≥25%. EGFR and KRAS mutations were not associated with a prognostic impact.

Conclusion
A prognostic impact for NSCLC patients receiving adjuvant chemotherapy was not associated with PD-L1 expression, or with EGFR and KRAS mutations.
Factors associated with research participation in a large primary care practice-based pediatric cohort: Results from the TARGet Kids! longitudinal cohort study
Authors: Li Xuedi , Keown-Stoneman Charles D. G. , Borkhoff Cornelia M. , Wong Peter D. , Arafeh Dana , Tavares Erika , Thadani Sharon , Maguire Jonathon L. , Birken Catherine S. ,   on behalf of the TARGet Kids! Collaboration
Published: April 2023

Background
All longitudinal cohort studies strive for high participant retention, although attrition is common. Understanding determinants of attrition is important to inform and develop targeted strategies to improve study participation. We aimed to identify factors associated with research participation in a large children’s primary care cohort study.

Methods
In this longitudinal cohort study between 2008 and 2020, all children who participated in the Applied Research Group for Kids (TARGet Kids!) were included. TARGet Kids! is a large primary care practice-based pediatric research network in Canada with ongoing data collection at well-child visits. Several sociodemographic, health, and study design factors were examined for their associations with research participation. The primary outcome was attendance of eligible research follow-up visits. The secondary outcome was time to withdrawal from the TARGet Kids! study. Generalized linear mixed effects models and Cox proportional hazard models were fitted. We have engaged parent partners in all stages of this study.

Results
A total 10,412 children with 62,655 total eligible research follow-up visits were included. Mean age at enrolment was 22 months, 52% were male, and 52% had mothers of European ethnicity. 68.4% of the participants attended at least 1 research follow-up visit. Since 2008, 6.4% of the participants have submitted a withdrawal request. Key factors associated with research participation included child age, ethnicity, maternal age, maternal education level, family income, parental employment, child diagnosis of chronic health conditions, certain study sites, and missingness in questionnaire data.

Conclusions
Socioeconomic status, demographic factors, chronic conditions, and missingness in questionnaire data were associated with research participation in this large primary care practice-based cohort study of children. Results from this analysis and input from our parent partners suggested that retention strategies could include continued parent engagement, creating brand identity and communication tools, using multiple languages and avoiding redundancy in the questionnaires.
The Beneficial Effects of Lactobacillus GG Therapy on Liver and Drinking Assessments in Patients with Moderate Alcohol-Associated Hepatitis
Authors: Vatsalya Vatsalya , Feng Wenke , Kong Maiying , Hu Huirong , Szabo Gyongyi , McCullough Arthur , Dasarathy Srinivasan , Nagy Laura E. , Radaeva Svetlana , Barton Bruce , Mitchell Mack , McClain Craig J. 
Published: April 2023

INTRODUCTION:
We investigated the effect of daily oral Lactobacillus rhamnosus GG (LGG) in reducing liver injury/severity and drinking in patients with alcohol use disorder and moderately severe alcohol-associated hepatitis.

METHODS:
Forty-six male and female individuals with alcohol use disorder and moderate alcohol-associated hepatitis (12 ≤ model for end-stage liver disease score < 20, aged 21–67 years) received either LGG (n = 24) or placebo (n = 22). Data were collected/assessed at baseline and at 1, 3, and 6 months.

RESULTS:
LGG treatment was associated with a significant reduction in liver injury after 1 month. Six months of LGG treatment reduced heavy drinking levels to social or abstinence levels.

DISCUSSION:
LGG treatment was associated with an improvement in both liver injury and drinking.