bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phylogeny and biogeography of the algal DMS-releasing enzyme in the global ocean
Authors: Shemi Adva , Ben-Dor Shifra , Rotkopf Ron , Dym Orly , Vardi Assaf 
Published: July 2023

Abstract
Phytoplankton produce the volatile dimethyl sulfide (DMS), an important infochemical mediating microbial interactions, which is also emitted to the atmosphere and affecting the global climate. Albeit the enzymatic source for DMS in eukaryotes was elucidated, namely a DMSP lyase (DL) called Alma1, we still lack basic knowledge regarding its taxonomic distribution. We defined unique sequence motifs which enable the identification of DL homologs (DLHs) in model systems and environmental populations. We used these motifs to predict DLHs in diverse algae by analyzing hundreds of genomic and transcriptomic sequences from model systems under stress conditions and from environmental samples. Our findings show that the DL enzyme is more taxonomically widespread than previously thought, as it is encoded by known algal taxa as haptophytes and dinoflagellates, but also by chlorophytes, pelagophytes and diatoms, which were conventionally considered to lack the DL enzyme. By exploring the Tara Oceans database, we showed that DLHs are widespread across the oceans and are predominantly expressed by dinoflagellates. Certain dinoflagellate DLHs were differentially expressed between the euphotic and mesopelagic zones, suggesting a functional specialization and an involvement in the metabolic plasticity of mixotrophic dinoflagellates. In specific regions as the Southern Ocean, DLH expression by haptophytes and diatoms was correlated with environmental drivers such as nutrient availability. The expanded repertoire of putative DL enzymes from diverse microbial origins and geographic niches suggests new potential players in the marine sulfur cycle and provides a foundation to study the cellular function of the DL enzyme in marine microbes.
The role of methionine synthases in fungal metabolism and virulence
Authors: Scott Jennifer , Amich Jorge 
Published: July 2023

Abstract
Methionine synthases (MetH) catalyse the methylation of homocysteine (Hcy) with 5-methyl-tetrahydrofolate (5, methyl-THF) acting as methyl donor, to form methionine (Met) and tetrahydrofolate (THF). This function is performed by two unrelated classes of enzymes that differ significantly in both their structures and mechanisms of action. The genomes of plants and many fungi exclusively encode cobalamin-independent enzymes (EC.2.1.1.14), while some fungi also possess proteins from the cobalamin-dependent (EC.2.1.1.13) family utilised by humans. Methionine synthase’s function connects the methionine and folate cycles, making it a crucial node in primary metabolism, with impacts on important cellular processes such as anabolism, growth and synthesis of proteins, polyamines, nucleotides and lipids. As a result, MetHs are vital for the viability or virulence of numerous prominent human and plant pathogenic fungi and have been proposed as promising broad-spectrum antifungal drug targets. This review provides a summary of the relevance of methionine synthases to fungal metabolism, their potential as antifungal drug targets and insights into the structures of both classes of MetH.
Day‐ahead operation strategy for multiple data centre prosumers: A cooperative game approach
Authors: Yang Zhihao , Liu Haoming , Ni Ming 
Published: July 2023

AbstractThe transferrable characteristics of workloads both spatial and temporal have received much attention recently. A data centre prosumer (DCP) is created by combining multiple data centre buildings, which contain workloads, photovoltaic generations, and battery energy storage systems (BESSs). Few studies have considered electricity trading and payoff sharing among various DCPs in a data centre park. This paper presents a cooperative framework for interconnected DCPs in a data centre park and proposes a novel day‐ahead operation strategy considering uncertainties in photovoltaic (PV) generations and workloads using the equivalent linear robust reformation method. The operation strategy is formulated as an asymmetric Nash bargaining cooperative game, which aims at maximizing the overall payoff of the cooperative alliance while considering the contributions of shared electricity to share the payoff. To solve the formulated cooperative game problem while preserving user privacy, an enhanced self‐adaptive prediction‐correction‐based alternating direction multiplier method (PCB‐ADMM) algorithm with adaptive penalty coefficients to accelerate convergence is employed in a distributed manner. The case studies indicate a 6.63% reduction in overall cost and verify the feasibility and fairness of the proposed cooperative strategy. The enhanced self‐adaptive PCB‐ADMM algorithm also shows superiority over other ADMM algorithms in effectiveness and rationality.
Faktoren für die Implementierung von KI-basierten
Entscheidungsunterstützungssystemen zur Antibiotikavorhersage im
Krankenhaus – eine qualitative Analyse aus der Perspektive von
ärztlichem Personal
Authors: Tokgöz Pinar , Hafner Jessica , Dockweiler Christoph 
Published: July 2023

Zusammenfassung
Hintergrund Entscheidungsunterstützungssysteme auf Basis
künstlicher Intelligenz können dazu beitragen, den
Antibiotikaeinsatz im Krankenhaus zu optimieren und die Entstehung von
Resistenzen vorzubeugen. Das Ziel der vorliegenden Untersuchung ist es, hemmende
und fördernde Faktoren für eine erfolgreiche Implementierung aus
Perspektive von ärztlichem Personal herauszuarbeiten.
Methode Es wurden 14 problemzentrierte Interviews mit ärztlichem
Personal aus der stationären Versorgung durchgeführt und anhand
der strukturierenden Inhaltsanalyse nach Kuckartz qualitativ ausgewertet.
Ergebnisse Entlang des Human-Organization-Technology-fit-Modells wurden
Haltungen aus der Perspektive des ärztlichen Personals dargestellt.
Technologie- und organisationsbezogene Themen stellen bedeutende Faktoren
für die Implementierung dar. Vor allem die Kompatibilität mit
bestehenden Systemen sowie die Benutzerfreundlichkeit des Systems nehmen einen
hohen Stellenwert bei einer erfolgreichen Implementierung ein.
Zusätzlich wird die Einarbeitung von potenziellen Nutzergruppen und die
technische Ausstattung der Organisation als zentral erachtet. Nicht zuletzt gilt
es die Technikkompetenzen potenzieller Nutzergruppen nachhaltig zu
fördern und Vertrauen für das System zu schaffen.
Schlussfolgerungen Die Ergebnisse bieten eine Basis, um im Folgeschritt
die identifizierten Faktoren quantitativ priorisieren zu können. Es wird
deutlich, dass beim Einsatz von Entscheidungsunterstützungssystemen
neben Systemeigenschaften auch kontextspezifischen und nutzerbezogenen
Gegebenheiten eine zentrale Bedeutung zukommt, um Systemvertrauen und eine
langfristige Implementierung zu gewährleisten.
Aus Fehlern lernen – qualitative Analyse von Gutachten zu
hausärztlichen Behandlungsfehlern
Authors: Förster Christian , Lorenz Gernot , Wilke Marko , Eissler Manfred , Joos Stefanie , Koch Roland 
Published: July 2023

Zusammenfassung
Hintergrund Die Gutachterkommissionen der Ärztekammern
ermöglichen eine kostenfreie und außergerichtliche Bewertung von
putativen ärztlichen Behandlungsfehlern. Sie erstellen Gutachten, die
wertvolle Angaben zu Prozessschritten beinhalten, die dem eigentlichen
Behandlungsfehler vorangehen. Ziel der vorliegenden Studie ist es,
Prozessschritte in den Gutachtentexten zu identifizieren und systematisch zu
kategorisieren, um damit die Voraussetzung für eine Auseinandersetzung
mit Fehlern zu ermöglichen.
Methodik In dieser Studie werden zehn zufällig ausgewählte
und anonymisierte Gutachten der Gutachterkommission für Fragen
ärztlicher Haftpflicht der Bezirksärztekammer
Südwürttemberg mit festgestellten hausärztlichen
Behandlungsfehlern nach der Methode der qualitativen Inhaltsanalyse ausgewertet.
In einem iterativen Prozess wurden zentrale Elemente von Gutachten in ein
deduktiv-induktiv erstelltes Kategoriensystem eingeordnet.
Ergebnisse Es wurden sechs Hauptkategorien mit zugehörigen
Unterkategorien identifiziert: 1) Strukturmerkmale des Gutachtens, 2)
Arzt-Patienten-Kommunikation, 3) medizinischer Verlauf, 4) Patientenerleben, 5)
Handlung Praxisteam, 6) Koordinierende Funktion im Gesundheitssystem. Das
Kategoriensystem zeigte bei wiederholter Anwendung eine ausreichende
Reliabilität.
Schlussfolgerungen Fehler bieten die Chance, aus ihnen zu lernen. Die
vorgeschlagene Systematik kann die Komplexität von Gutachten
strukturieren und dadurch in verschiedenen Kontexten als Hilfsmittel dienen.
Insbesondere ermöglicht sie eine differenzierte Betrachtung bei der
Erstellung und vergleichenden Analyse von Gutachten und könnte in der
Versorgungsforschung sowie in der Aus- und Weiterbildung genutzt werden.
Evaluation of Fetal Cardiac Output and Modified Myocardial
Performance Index in Pregnant Women with Idiopathic Polyhydramnios: A Case
Control Study from a Tertiary Hospital
Authors: Sakcak Bedri , Denizli Ramazan , Farisoğulları Nihat , Haksever Murat , Turgut Ezgi , Kara Ozgur , Tanacan Atakan , Sahin Dilek 
Published: July 2023

Abstract
Purpose This study aimed to investigate fetal cardiac output and
myocardial performance index in pregnant women with idiopathic polyhydramnios
and compare them to healthy pregnant women.
Methods Thirty patients admitted to Ankara City Hospital at 24–39
weeks of gestation with idiopathic polyhydramnios were included as the study
group. Clinical characteristics, fetal cardiac output, and fetal modified
myocardial performance index (Mod-MPI) were compared between the groups.
Results The combined cardiac output (CCO), left cardiac output (LCO),
right cardiac output (RCO), pulmonary artery velocity time integral (PA-VTI),
and aortic VTI were statistically significantly higher in the study group
(p=0.003, p=0.028, p=0.002, p=0.000, and
p=0.017, respectively).The idiopathic polyhydramnios group had a
significantly higher Mod-MPI and isovolumetric contraction time (ICT) and a
significantly lower ejection time (ET) compared to the controls (p=000,
p=0.003, and p=0.023, respectively). In the idiopathic
polyhydramnios group, the aortic max (p=0.009) and aortic VTI
(p=0.047) values were significantly lower and the left ventricular
outflow tract isovolumetric relaxation time (LVOT-IRT) (p=0.021) was
significantly higher in cases where the NICU was required. According to the ROC
analysis performed in the idiopathic polyhydramnios group, the optimal cut-off
values of aortic max, aortic VTI, and LVOT-IRT in the prediction of the NICU
requirement were (57.5, 0.089 and 41.5, respective cut-off value)
(p=0.010, p=0.048, p=0.021, respectively).
Conclusions Both fetal cardiac output and Mod-MPI values were altered in
fetuses with idiopathic polyhydramnios.
Long-Term Recurrence Rates and Patient Satisfaction after Repair of Pectus Excavatum
Authors: Cruz-Centeno Nelimar , Fraser James A. , Stewart Shai , Marlor Derek R. , Oyetunji Tolulope A. , St Peter Shawn D. 
Published: July 2023

Abstract
Background Pectus excavatum deformities are usually repaired with a minimally invasive approach in which a metal bar is used to correct the chest wall abnormality. We aimed to evaluate long-term outcomes and patient satisfaction after surgical correction.
Methods Patients who underwent pectus excavatum repair and subsequent bar removal at a single tertiary care center from January 2000 to December 2020 were identified. A retrospective chart review was performed, and a telephone survey was conducted to evaluate perceived inward chest movement, need for surgeon reevaluation, surgical reintervention, and overall satisfaction. Data are presented as medians with interquartile ranges (IQRs) and frequencies with percentages.
Results A total of 583 patients were included. The survey response rate was 26.2% (n = 153). The respondents were predominantly male (80.4%, n = 123) with a median age at surgical correction of 14.9 years (IQR 12.9, 16.1) and a median Haller index (HI) of 3.8 (IQR 3.4, 4.5). Median time to bar removal was 2.9 years (IQR 2.5, 3.0) with a median age at removal of 17.7 years (IQR 15.5, 19.0). Median time from surgery to survey follow-up was 9.6 years (IRQ 5.0, 11.4) with respondents having a median age at follow-up of 25 years (IQR 22.0, 28.4). The satisfaction rate was 96.7% (n = 148) with a reintervention rate of 2.0% (n = 3). The perceived inward chest movement was 30.7% (n = 47) with 12.8% (n = 6) of those requesting surgical reevaluation.
Conclusion There is a high level of satisfaction many years after correction of pectus excavatum and bar removal. With the advent of cryoablative therapy since 2017, patient satisfaction improved by experience of less postoperative pain. Reintervention rate is low despite some patients reporting a perceived chest wall inward movement.
Texture and color enhancement imaging versus high definition white-light endoscopy for detection of colorectal neoplasia: a randomized trial
Authors: Antonelli Giulio , Bevivino Gerolamo , Pecere Silvia , Ebigbo Alanna , Cereatti Fabrizio , Akizue Naoki , Di Fonzo Michela , Coppola Manuela , Barbaro Federico , Walter Benjamin M. , Sharma Paranjay , Caruso Anna , Okimoto Kenichiro , Antenucci Claudia , Matsumura Tomoaki , Zerboni Giulia , Grossi Cristina , Meinikheim Michael , Papparella Luigi Giovanni , Correale Loredana , Costamagna Guido , Repici Alessandro , Spada Cristiano , Messmann Helmut , Hassan Cesare , Iacopini Federico 
Published: July 2023

Background Texture and color enhancement imaging (TXI) was recently proposed as a substitute for standard high definition white-light imaging (WLI) to increase lesion detection during colonoscopy. This international, multicenter randomized trial assessed the efficacy of TXI in detection of colorectal neoplasia.
Methods Consecutive patients aged ≥ 40 years undergoing screening, surveillance, or diagnostic colonoscopies at five centers (Italy, Germany, Japan) between September 2021 and May 2022 were enrolled. Patients were randomly assigned (1:1) to TXI or WLI. Primary outcome was adenoma detection rate (ADR). Secondary outcomes were adenomas per colonoscopy (APC) and withdrawal time. Relative risks (RRs) adjusted for age, sex, and colonoscopy indication were calculated.
Results We enrolled 747 patients (mean age 62.3 [SD 9.5] years, 50.2 % male). ADR was significantly higher with TXI (221/375, 58.9 %) vs. WLI (159/372, 42.7 %; adjusted RR 1.38 [95 %CI 1.20–1.59]). This was significant for ≤ 5 mm (RR 1.42 [1.16–1.73]) and 6–9 mm (RR 1.36 [1.01–1.83]) adenomas. A higher proportion of polypoid (151/375 [40.3 %] vs. 104/372 [28.0 %]; RR 1.43 [1.17–1.75]) and nonpolypoid (136/375 [36.3 %] vs. 102/372 [27.4 %]; RR 1.30 [1.05–1.61]) adenomas, and proximal (143/375 [38.1 %] vs. 111/372 [29.8 %]; RR 1.28 [1.05–1.57]) and distal (144/375 [38.4 %] vs. 98/372 [26.3 %]; RR 1.46 [1.18–1.80]) lesions were found with TXI. APC was higher with TXI (1.36 [SD 1.79] vs. 0.89 [SD 1.35]; incident rate ratio 1.53 [1.25–1.88]).
Conclusions TXI increased ADR and APC among patients undergoing colonoscopy for various indications. TXI increased detection of polyps < 10 mm, both in the proximal and distal colon, and may help to improve colonoscopy quality indicators.
Exclusive Breastfeeding in the Bronx—Successes and Shortcomings
Authors: Grande Julia , Liu Jianyou , Nemerofsky Sheri 
Published: July 2023

Objective Despite efforts to encourage breastfeeding, exclusive breastfeeding (EBF) rates in the Bronx remain suboptimal. Hospital restrictions and uncertainty surrounding the side effects of coronavirus disease 2019 (COVID-19) greatly impacted the mother–infant dyad during the postpartum hospitalization. Preliminary studies found an initial decrease in EBF, but lasting effects remain unknown. This study aimed to investigate the effect of the COVID-19 pandemic on birth hospitalization EBF rates among a high-risk urban patient population.
Study Design A retrospective chart review was conducted on all newborns admitted to the newborn nursery at an urban medical center between 2019 and 2021. Patients were separated into prepandemic and pandemic cohorts. Patient demographics, maternal comorbidities, length of stay, feeding method, and newborn characteristics, including status as high risk for hypoglycemia, were collected. EBF was defined as receiving only mother's milk during the birth hospitalization. Descriptive statistics and bivariate analysis were used to examine the data.
Results A total of 630 prepandemic and 643 pandemic newborns were included. The cohorts did not differ in baseline maternal characteristics. Prepandemic newborns were less likely to be high risk (23.3 vs. 29.4%, p = 0.01), more likely to see the hospital lactation consultant (53.2 vs. 24.0%, p < 0.001), and had a longer average length of stay (63.4 vs. 54.5 hours, p < 0.001). Most infants in both cohorts received some breastmilk during the hospitalization (97.6 vs. 94.6%, not significant). There was no difference in EBF between cohorts among all newborns (9.5 vs. 11.4%, p = 0.29) or among nonhigh-risk newborns (12.2 vs. 15.0%, p = 0.22).
Conclusion EBF rates in the Bronx, NY did not change during the pandemic period, despite an increase in high-risk newborns. Further investigation into the effect of lactation consultation, maternal race, ethnicity, and primary language should be further explored to understand the implications of health care disparities on the mother–infant dyad.
Key Points
The role of networks in international acquisition premiums
Authors: Li Chengguang , Luo Yadong , Bu Juan , Tang Yinuo 
Published: July 2023

AbstractOur work builds on network theory to investigate the role of alliance networks in international acquisition premiums. On the one hand, we postulate that an international acquirer’s network centrality in the target country lowers the inclination of offering higher bid premiums associated with its liability of foreignness (i.e., negatively moderates the relation between foreignness and premiums). On the other hand, we provide a perspective that a target firm’s local network centrality increases an international acquirer’s willingness to pay higher premiums in order to gain access to unique and valuable local knowledge and resources (i.e., positively moderates the relationship between foreignness and premiums). To test our hypotheses, we analyzed a sample of 1693 related acquisition bids made in more than 40 countries between 2008 and 2017. Our findings support our dual perspective on the role of networks and demonstrate that the acquirer's networks and the target's networks have distinct influences on the relationship between foreignness and bid premiums. This study makes contributions to the understanding of the complex dynamics at play in international M&As and emphasizes the importance of distinguishing between the acquirer’s and the target’s networks in shaping acquisition premiums.
Global existence and time-decay rates of solutions to the generalized Boussinesq equation with weak damping
Authors: Wang Yinxia , Luo Zehua , Li Dan 
Published: July 2023

In this paper, we study the initial value problem for the generalized Boussineq equation with weak damping. The existence and time-decay rates of global solutions and its derivatives are established for all space dimensions d ≥ 1, provided that the norm of the initial data is suitably small. The negative Sobolev norms of the initial data in low frequency are shown to be preserved along time evolution and enhance the decay rates of global solutions. The proof is based on the energy method and flexible interpolation trick without investigating the corresponding linear equation.
Improvement of image-type very-low-energy-electron-diffraction spin polarimeter
Authors: Zha Heming , Liu Wenjing , Wang Deyang , Zhao Bo , Shen Xiaoping , Ye Mao , Qiao Shan 
Published: July 2023

Spin- and angle-resolved photoemission spectroscopy (SARPES) with high efficiency and resolution plays a crucial role in exploring the fine spin-resolved band structures of quantum materials. Here, we report the performance of the SARPES instrument with a second-generation home-made multichannel very-low-energy-electron-diffraction spin polarimeter. Its energy and angular resolutions achieve 7.2 meV and 0.52°, respectively. We present the results of SARPES measurements of Bi(111) film to demonstrate its performance. Combined with the density functional theory calculations, the spin polarization of the bulk states was confirmed by the spin-layer locking caused by the local inversion asymmetry. The surface states at a binding energy of 0.77 eV are found with 1.0 ± 0.11 spin polarization. Better resolutions and stability compared with the first-generation one provide a good platform to investigate the spin-polarized electronic states in materials.
High precision control of laser energy for laser–matter interaction studies
Authors: Wang Xiaoming , Zhang Jun , Sethian John 
Published: July 2023

Precise, highly reproducible control of the laser energy is required for high confidence laser–matter interaction research such as in dynamic compression science and high energy density physics. The energy must be adjustable without affecting the pulse shape (time varying intensity) or beam smoothness. We have developed a convenient two-stage energy tuning method for a nominal 100 J, 351 nm (UV) laser. The energy is adjusted in 10 J (10%) increments by operating the laser at full energy and inserting a beam splitter in the laser output. As the splitter is located after the final frequency tripling optics, the UV pulse shape is unchanged. The energy is varied by substituting a splitter of different reflectivity. For finer 3 J (3%) increments, the infrared pulse is attenuated inside the laser before the final amplifier. This requires modest tuning to preserve the pulse shape. The demonstrated variation in shot-to-shot reproducibility is less than +/−2.5 J (5% of the full energy), irrespective of the laser output energy. These approaches can be adapted to most ∼100 J class lasers. We describe these techniques and show two examples where they have elucidated the underlying physics in laser shock compression experiments. One used only the beam splitters to establish the pressure for melting in iron. The other combined both techniques to finely increment the peak stress (∼2 GPa steps) in germanium to precisely determine the onset and completion of melting—including the melting kinetics. These unambiguous results would not be possible without the developments described here.