bluuebunny/crossref_metadata_2025_split huggingface dataset:
Feasibility of mail-based biospecimen collection in an online preconception cohort study
Authors: Koenig Martha R. , Wesselink Amelia K. , Kuriyama Andrea S. , Chaiyasarikul Alina , Hatch Elizabeth E. , Wise Lauren A. 
Published: January 2023

BackgroundProspective cohort studies that enroll participants before conception are crucial for deepening scientific understanding of how the preconception environment influences reproductive outcomes. While web-based research methods provide efficient and effective strategies to collect questionnaire-based data, few of these studies incorporate biospecimen collection, which can enhance the validity of exposure assessment. There is limited literature on the feasibility and cost-effectiveness of collecting biospecimens in web-based preconception cohort studies.MethodsWe evaluated the feasibility and cost-effectiveness of in-clinic and mail-based biospecimen collection in Pregnancy Study Online (PRESTO), a North American web-based preconception cohort study. Both members of the couple were eligible to participate if their conception attempt time was ≤3 months at enrollment. We invited study participants from the Boston, MA and Detroit, MI metropolitan areas to attend a study visit and provide urine and blood (hereafter “in-clinic protocol”). We invited all other participants to complete mail-based collection of urine and blood spots (hereafter “mail-based protocol”). We compared overall consent and protocol completion rates, demographic characteristics of those who consented and completed either of the protocols, and costs between mail-based and in-clinic protocols for biospecimen collection. Finally, we described logistical challenges pertaining to reliance on mail-based delivery of time-sensitive biospecimens compared with in-clinic methods.ResultsDuring January 2022-July 2022, 69% of female participants (134/195) and 42% of male participants (31/74) consented to participate in the mail-based protocol. Consent rates for the in-clinic protocol were 39% for female participants (289/739 during March 2014-July 2022) and 25% for male participants (40/157 during March 2017-July 2022). Participants who consented to participate were generally of higher socioeconomic position than non-participants. Deviations from the protocol occurred more frequently within the mail-based protocol but were easily corrected. The cost per participant enrolled was similar across protocols (mail-based: $276.14 vs. in-clinic: $270.38).ConclusionsOur results indicate that mail-based collection of biospecimens may create opportunities to recruit a larger and more geographically diverse participant population at a comparable cost-per-participant enrolled to in-clinic methods.
Economic analysis of sesame (Sesamum indicum L.) production in Northern Benin
Authors: Dossa Kossivi Fabrice , Enete Anselm Anibueze , Miassi Yann Emmanuel , Omotayo Abiodun Olusola 
Published: January 2023

IntroductionSesame is an important cash crop that can be grown with limited resources. In recent decades it has drawn interests of many researchers and developers. This study analyzed the economics of Sesame (Sesamum indicumL.) produced in northern region of the Republic of Benin.MethodsStructured questionnaire was used to gather primary data from 120 farmers who made up the sample size and were chosen using a multistage sampling technique. Data were analyzed using descriptive statistics, profitability analytical tools, multiple regression analysis and Likert scale rating technique. Profitability analytical tools were used to assess the economic performance of the sesame production; a multiple regression model was used to analyze factors that determine the output of the production in the study area; a 5-point Likert scale rating technique was utilized to rank the production's challenges according to farmers' observations.ResultsThe findings revealed that sesame is mainly produced in sole cropping system and in rotation with other crops. The net farm income analysis showed that sesame farming was a profitable venture in the study area. The study also showed that factors like age, household size, crop rotation, and capital input influence the revenue of sesame production. While age, household size and capital input have a beneficial and significant influence on the farms' net revenue from sesame produce, crop rotation has a negative effect on it. Amongst the various constraints identified, the most significant ones are access to labor and land, uneven ripening, lack of storage facilities and access to improved seed.DiscussionBased on these results, authorities in agricultural sector should develop and promote this value chain at the national level as it will greatly boost the country's economy.
TERT genetic polymorphism rs2736100 is associated with an aggressive manifestation of papillary thyroid carcinoma
Authors: Nie Xilin , Shang Jinbiao , Wang Wendong 
Published: January 2023

ObjectivesTERT rs2736100 genetic polymorphism is commonly found in human malignancies, indicating its key role in cancer cell transformation. The aim of this study is to investigate the effects of the functional TERT rs2736100 genetic polymorphism on the outcomes of papillary thyroid carcinoma (PTC) patients.Materials and methodsWe performed a retrospective study on the relationship between rs2736100 and clinicopathological outcomes of PTC in 500 patients (378 females and 122 males) aged 43.8 ± 11.4 years (range 15–74 years) with a median follow-up of 60 months (range, 1–455 months).ResultsTERT rs2736100 genetic polymorphism (TG/GG vs. TT) was significantly associated with several high-risk clinicopathological features such as tumor spread, extrathyroidal extension, central/lateral lymph node metastases, and Stage T III or IV disease. However, in Kaplan–Meier survival analyses, the rs2736100 mutation was unrelated to overall disease-free survival with a log-rank value of p &gt; 0.05. In Cox-regression analyses, the overall survival rate of recurrence/neo-metastasis was related to a larger tumor size, younger age, and tumor spread but unrelated to the rs2736100 mutation.Conclusions and significanceTERT rs2736100 genetic polymorphism mutation is more likely to manifest with aggressive clinicopathological characteristics but cannot worsen prognosis in PTC.
Strengthen the sacral ligament and paravagina by equilibrium control severe pelvic organ prolapse
Authors: Zhao Xin , Niu Jumin , Liu Yansong 
Published: January 2023

ObjectiveTo evaluate and analyze the clinical effect of the combination of laparoscopic sacrocolpopexy (LSC), sacral ligament fusion and vaginal suspension in the treatment of severe pelvic organ prolapseMethodsA total of 76 cases of patients with pelvic organ prolapse in our hospital between January 2010 to December 2020 were enrolled for research. They had been evaluated pre- and post-operative through pelvic organ prolapse quantification (POP-Q) system, Pelvic Floor Dysfunction Questionnaire Short Form (PFDI-20), Pelvic Floor Function Impact Questionnaire Short form (PFIQ-7), and the Sexual Function Questionnaire Score (PIQS-31).ResultsAll 76 patients went through the procedure successfully without any complications. None of the 76 cases had relapsed. Post-operational results of PFDI-20 and PFIQ-7 were evidently lower than pre-operational results, post-operational results of PIQS-31 were higher than before operation.ConclusionsFor patients with severe pelvic organ prolapse,a balanced control of the pelvic floor centred on the preservation of the stereoscopic ring around the cervix through revascularization is significantly effective, and has no recurrence after surgery, high patient satisfaction, fewer postoperative complications. It is safe and reliable and worthy of clinical application and promotion.
Vertebral refracture after percutaneous vertebroplasty for osteoporotic vertebral compression fractures with and without brace wearing: A retrospective study of 300 patients
Authors: Xinyu Guo , Na Zhu , Haihong Zhang , Dingjun Hao 
Published: January 2023

BackgroundThe aim of the study was to examine the clinical incidence rate of vertebral body fractures after percutaneous vertebroplasty (PVP) with and without brace wearing and provide a new guiding ideology for preventing vertebral fractures after clinical surgeries.MethodsThe retrospective analysis included 100 outpatients who underwent PVP between January 2017 and December 2018 without bracing after PVP surgeries (non-brace-wearing group). In total, 100 patients were paired into the rigid brace group and 100 patients were paired into the soft braces group according to propensity score matching. Seven independent variables were used in the soft and rigid brace group: age, sex, body mass index (BMI), visual analog scale (VAS), Oswestry Disability Index (ODI), and Cobb angle. The VAS, ODI, and Japanese Orthopaedic Association (JOA) scores were recorded preoperatively on the second day, after 1 month, after 3 months, and during the last follow-up postoperatively. We recorded the incidence of vertebral refracture in each of the three groups of patients and evaluated the effect of braces on postoperative fractures based on the ODI, VAS, and JOA scores.ResultsAll patients were followed up for 8–24 months (mean 22.4 months). Compared with the preoperative values, the age, sex, BMI, bone density, ODI, VAS, and Cobb angle between refracture and non-refracture were not statistically significant. The VAS, ODI, and JOA scores significantly increased in the brace-wearing group compared with those of the non-brace-wearing group (p &lt; 0.05). The incidence of vertebral refracture in the brace-wearing group was lower than that in the non-brace-wearing group, between which there was a significant difference (p &lt; 0.05). Three months postoperatively, the JOA score of the soft brace group was significantly higher than that of the rigid brace group (p &lt; 0.05). During the last follow-up, it was found that there was no difference in the VAS score, the incidence of refracture, or ODI between the soft brace group and the rigid brace group (p &gt; 0.05). The improvement in the JOA score of the soft brace group was better than that of the rigid brace group, between which there was a significant difference (p &lt; 0.05).ConclusionBraces can improve the prognosis of quality of life and postoperative subjective perception, whose presence can relieve postoperative residual pains. In contrast, patients can have a better medical experience wearing a soft brace.
Perspectivas para o Hidrogênio Verde: uma análise à luz do modelo da Hélice Tríplice
Authors: Ribeiro Filho José de Ribamar , Tahim Elda Fontinele , Veras Vanessa Maria Vasconcelos 
Published: January 2023

Esta pesquisa tem por objetivo contribuir para estudos das perspectivas sobre o Hidrogênio Verde sob a ótica do modelo da Hélice Tríplice da Inovação (Universidade — Indústria — Governo) desenvolvido por Etzkowitzv (1990), Etzkowitz e Leydesdorff (1995), identificando o caminho para a configuração do modelo conforme padrões opostos: modelo estatista, onde o governo detém o controle da academia e da indústria, e; modelo laissez-faire, em que universidade, indústria e governo interagem de forma modesta, estando separados por firmes fronteiras, como explicam Etzkowitz e Zhou (2017). Foi enredado como seu objeto de pesquisa o contexto de desenvolvimento de cenários para o desenvolvimento do Hidrogênio Verde no estado do Ceará, que envolvem sua produção, uso, transporte, armazenamento, bem como o comércio no mercado nacional e sua exportação. Um grupo de especialistas com representantes das três hélices foi elencado para as entrevistas, que seguiram um roteiro semiestruturado. Trata-se de uma pesquisa com abordagem de cunho qualitativo com apropriação da estratégia de investigação estudo de caso descritivo. As análises dos dados foram realizadas por intermédio de uma Análise Proposicional do Discurso (APD), técnica que identifica “universo de referências” adaptando-se a materiais verbais produzidos em entrevistas, conforme Bardin (2016), contando com o auxílio do software Iramuteq para formação de classes e segmentos de textos. Em conclusão foi observado que as interações entre as três esferas que compõem o modelo, para o caso do cenário do Hidrogênio Verde no estado do Ceará, têm ocorrências desde sua idealização, o que estabelece que o caminho da formação da Hélice Tríplice não corresponde a qualquer um dos dois exemplares, estatista ou “laissez-faire”. Desdobramentos da Hélice Tríplice (quádrupla e quíntupla) podem estabelecer conexões com este estudo em pesquisas futuras.
ICOMOS International Cultural Tourism Charters 1976-2021: evolution, contributions and trends in cultural heritage protection
Authors: Martínez Yáñez Celia 
Published: January 2023

Since its establishment in the sixties, the standard setting texts produced by ICOMOS have become the most reputed, influential and distributed documents concerning cultural heritage protection worldwide. An examination of all ICOMOS charters and recommendations makes clear the indispensable role of this organisation to disseminating best conservation, restoration and management practices during the last sixty years. It also demonstrates its persistence to never give up to the countless pressures that challenge heritage preservation around the world. Tourism is undoubtedly one of the most important and global of these pressures due to its considerable influence at all levels of cultural heritage management and decision-making. This paper analyses the early, pioneer and crucial role of ICOMOS to promote responsible tourism through an evaluation of its international cultural tourism charters from 1976, when the first was adopted, until 2021, when the Advisory Council of the organisation has approved the ICOMOS Draft International Charter for Cultural Heritage Tourism (2021): Reinforcing cultural heritage protection and community resilience through responsible and sustainable tourism management for its adoption at the ICOMOS General Assembly in 2022. The long process for drafting and approving this Charter and its new conceptual approaches show the emerging trends affecting cultural heritage globally and allow reflecting more broadly about the future of standard setting texts on this subject.
Sosialisasi Dampak Kecanduan Bermain Game Online Terhadap Motivasi Belajar Pada Siswa di SDN Subangjaya 2 Kota Sukabumi
Authors: Andriani Ria , Basri Burhanuddin 
Published: January 2023

Tujuan sosialisasi pada siswa ini merupakan untuk memberikan pemahaman kepada siswa agar bisa membatasi diri dalam bermain game online di karnakan akan menggagu proses belajar dan pasti akan menurunkan prestasi belajar pada siswa. Hingga aktivitas ini dilaksanakan di SDN Subangjaya 2 Kota Sukabumi dengan jumlah partisipan 35 orang. Kegiatan Pkm yang di lakukan dengan ceramah serta dialog dengan memberiakan modul tentang dampak kecanduan bermain game online terhadap motivasi belajar pada siswa. Hasil capaian kegiatan ini antara laingar siswa dapat mengetahui akan dampak kecanduan bermain game online terhadap motivasi belajar dan memberikan solusi apa yang bisa dilakukan untuk mengatisipasi kecanduan bermain game online pada siswa SD. Dari angket didapatkan hasil ada perbe dan pengetahuan saat sebelum serta setelah di bagikan sosialisasi dampak kecanduan bermain game online terhadap motivasi belajar pada siswa SDN Subangjaya 2 Kota Sukabumi dengan nilai P- Value: 0, 000. Direkomendasikan Para guru-guru agar dapat memberikan pelayanan Bimbingan dan Konseling dalam mengurangi kecanduan game dan meningkatkan motivasi belajar siswa dengan memberikan layanan informasi tentang memanfaatkan waktu senggang dengan hal yang positif, serta informasi tentang dampak negatif dari kecanduan game.
Socializing the Impact of Online Game Addiction on Learning Motivation in Students at SDN Subangjaya 2 Sukabumi City
Nowadays online games are booming in the community, and the fans are not half-hearted, from children to adults. The negative impacts of playing games include decreasing concentration in learning at home and at school. The purpose of socialization to students is to provide understanding to students so that they can limit themselves in playing online games because it will interfere with the learning process and will definitely reduce student achievement. Until this activity was carried out at SDN Subangjaya 2 Sukabumi City with 35 participants. Pkm activities are carried out with lectures and dialogues by providing modules on the impact of addiction to playing online games on students' learning motivation. The results of this activity include other students being able to find out the impact of online game addiction on motivation and what solutions can be done to anticipate online game addiction in elementary school students. From the questionnaire, the results showed that there were differences and knowledge before and after the socialization of the impact of addiction to playing online games on learning motivation in SDN Subangjaya 2 Sukabumi students with a P-Value: 0.000. It is recommended that teachers be able to provide Guidance and Counseling services in reducing game addiction and increasing student learning motivation by providing information services about using free time for positive things, as well as information about the negative effects of game addiction
Kanker Prostat : Risiko dan pencegahannya.
Authors: Christina Shintia , Sanchia Hansel , Angka Rebecca Noerjani 
Published: January 2023

Kanker prostat menduduki urutan kedua setelah kanker paru pada laki-laki. Faktor resiko kanker prostat dibagi menjadi dua, yaitu yang tidak dapat diubah dan tidak dapat diubah. Faktor yang tidak dapat diubah adalah usia, etnis/ras dan riwayat keluarga. Faktor resiko yang dapat diubah adalah antropometri, merokok, kegiatan fisik dan pola makan. Faktor resiko tersebut dari beberapa literature disebutkan dapat meningkatkan resiko untuk terjadinya kanker prostat. Pencegahan terhadap kejadian kanker prostat dapat dilakukan dengan memodifikasi pola hidup berdasarkan faktor resiko yang dapat diubah, seperti memodifikasi pola makan, berat badan dan aktifitas fisik.
Validitas LKS Elektronik dalam Mendukung Keterampilan Abad 21 yang Berorientasi Problem Based Learning
Authors: Wulandari Karomah , Cintamulya Imas 
Published: January 2023

Tujuan penelitian dan pengembangan ialah mendeskripsikan validitas LKS elektronik berorientasi problem based learning dalam mengembangkan berpikir kritis siswa berdasarkan penilaian validator, dengan desain model ADDIE. Teknik pengumpulan data menggunakan lembar validasi. Pemaparan data kevalidan dengan cara menganalisis data. Hasil kevalidan produk dinilai oleh ketiga validator dengan kriteria isi, sistematika, kegrafisan, dan bahasa. Presentase kriteria isi dari validator I sebesar 75%, validator II 86,1%, dan validator III sebesar 86,1% dengan skor rata-rata presentasi 82,4% yang menunjukkan kriteria isi yaitu valid. Untuk kriteria sistematika dari validator I bernilai 91,7%, validator II sebesar 95,8%, dan validator III sebesar 95,8% dengan skor rata-rata sebesar 94,4% yang artinya sangat valid. Sedangkan untuk kriteria kegrafisan pada validator I sebesar 75%, validator II sebesar 85%, dan validator III bernilai 90%, dengan rata-rata presentase 83,3% yang artinya valid. Kriteria bahasa pada validator I bernilai 75%, validator II bernilai 81,3%, dan validator III bernilai 100%, dengan rata-rata presentase sebesar 85,4% dengan kategori valid. Secara umum, berdasarkan dari hasil validasi oleh ketiga validator yang meliputi kriteria isi, sistematika, kegrafisan, dan bahasa memiliki rata-rata presentase sebesar 86,4%. Dengan demikian, LKS elektronik berorientasi problem based learning untuk mengembangkan berpikir kritis siswa dinyatakan valid.
PERTANGGUNGJAWABAN HUKUM PIDANA TERHADAP NOTARIS SEBAGAI OKNUM MAFIA TANAH
Authors: Kusumojati Mega Puspa 
Published: January 2023

Oknum Mafia tanah merupakan dua orang atau lebih saling bekerja sama merampas tanah orang lain atau tanah negara. Tidaklah tepat, apabila hanya seorang Notaris yang menyebabkan penukaran sertifikat asli dan Palsu,penggelapan,penipuan sehingga perbuatan memenuhi unsur dalam tindakan pelanggaran hukum. Menggunakan Metode Riset Yuridis Normatif adapun berendekatan Perundang – undangan (Statue approach) dan Pendekatan kasus (Cases approach) bahwa payung hukum UU No. 2 Tahun 2014 atas perubahan Undang – undang Nomor 30 Tahun 2004 tentang Jabatan Notaris tidak ada ketentuan pidana diatur sehingga secara potensial terjadi berdasarkan KUHPidana. Dalam konteks Pertanggungjawaban Hukum Pidana terhadap Notaris atas Akta yang dibuatnya, Sebagai alternatif mewujudkan perlindungan bagi masyarakat yang dirugikan oleh Notaris sebagai Oknum Mafia Tanah. Hasil Penulisan ini kedepannya agar Pemerintah dan Menteri ATR/BPN (Badan Pertanahan Nasional) bersama – sama segera merancang aturan UU yang memberi pengaturan mengenai Pemberantasan Oknum Mafia tanah maka dalam menangani Kejahatan Mafia Tanah bisa dihapuskan dan melaksanakan pengontrolan ketat yang dilakukan Majelis Pengawas Daerah Notaris dan Majelis Pengawas Pusat Notaris agar Notaris yang menyalahgunakan kelalaian dalam menjalankan tugas jabatannya agar tidak ada cela bagi Oknum mafia tanah untuk melakukan kerjasama dengan Notaris.
PERJANJIAN KAWIN PASCA BERLAKUNYA PUTUSAN MAHKAMAH KONSTITUSI NOMOR 69/PUU-XIII/2015
Authors: Dwiputra Abel Edgar Anugrah 
Published: January 2023

Sejak dikeluarkannya Putusan Mahkamah Konstitusi No. 69/PUU-XIII/2015, maka terdapat pengaturan yang berbeda terkait perjanjian perkawinan, sebagaimana sebelumnya diatur dalam UU Perkawinan dan KUHPerdata.
semenjak adanya putusan tersebut, maka penting kiranya untuk memahami dan mengerti mengenai pengaturan perjanjian perkawinan beserta akibat hukumnya setelah adanya putusan tersebut. Metode penelitian yang digunakan adalah iyuridis normatif dengan berdasarkan pada pemahaman peraturaniperundang-undangan. Hasil dari penelitianiini menunjukkanbbahwa amar putusan MKRI No. 69/PUU-XIII/2015 memberikan tafsir konstitusional terhadap ketentuan Pasal 29 Ayat (1), (3), dan (4) UU Perkawinan. Jika sebelumnya, perjanjian perkawinan hanya dibatasi pada waktu atau sebelum perkawinan, maka dengan adanya putusan MK tersebut perjanjian perkawinan dapat dibuat pada waktu, sebelum dilangsungkan atau selama dalam ikatan perkawinan, dengan syarat perjanjian tersebut dibuat oleh kedua pihak atas persetujuan bersama dan disahkan oleh pegawai pencatat perkawinan atau notaris.
METODE PEMBELAJARAN PENDIDIKAN AGAMA KRISTEN MELALUI MUSIK GEREJAWI PADA ANAK
Authors: Kristiantoro Kristiantoro , Boiliu Fredik Melkias 
Published: January 2023

Penelitian ini bertujuan untuk membahas metode pembelajaran pendidikan agama Kristen melalui musik gereja pada anak. Metode ini merupakan salah satu pendekatan yang tidak kala penting dengan pendekatan lain. Metode pembelajaran PAK melalui musik gereja yang dikaji dalam penelitian adalah metode pembelajaran PAK mengalun dalam wiraga, mensyairkan dalam wirama, melodi dalam wirasa, mengekspresikan dalam wirupa. Metode yang digunakan dalam penelitian ini adalah metode peneltian kulitatif deskriptif. Hasil dari penelitian ini akan mendeskripsikan metode pembelajaran PAK yang digunakan sebagai pendekatan dalam pembelajaran melalui musik gereja.

Kata Kunci: Musik Gerejawai, Pendidikan Agama Kristen