bluuebunny/crossref_metadata_2025_split huggingface dataset:
The connection between nonzero density and spontaneous symmetry breaking for interacting scalars
Authors: Nicolis Alberto , Podo Alessandro , Santoni Luca 
Published: September 2023

Abstract
We consider U(1)-symmetric scalar quantum field theories at zero temperature. At nonzero charge densities, the ground state of these systems is usually assumed to be a superfluid phase, in which the global symmetry is spontaneously broken along with Lorentz boosts and time translations. We show that, in d > 2 spacetime dimensions, this expectation is always realized at one loop for arbitrary non-derivative interactions, confirming that the physically distinct phenomena of nonzero charge density and spontaneous symmetry breaking occur simultaneously in these systems. We quantify this result by deriving universal scaling relations for the symmetry breaking scale as a function of the charge density, at low and high density. Moreover, we show that the critical value of μ above which a nonzero density develops coincides with the pole mass in the unbroken, Poincaré invariant vacuum of the theory. The same conclusions hold non-perturbatively for an O(N) theory with quartic interactions in d = 3 and 4, at leading order in the 1/N expansion. We derive these results by computing analytically the zero-temperature, finite-μ one-loop effective potential, paying special attention to subtle points related to the iε terms. We check our results against the one-loop low-energy effective action for the superfluid phonons in λϕ4 theory in d = 4 previously derived by Joyce and ourselves, which we further generalize to arbitrary potential interactions and arbitrary dimensions. As a byproduct, we find analytically the one-loop scaling dimension of the lightest charge-n operator for the λϕ6 conformal superfluid in d = 3, at leading order in 1/n, reproducing a numerical result of Badel et al. For a λϕ4 superfluid in d = 4, we also reproduce the Lee-Huang-Yang relation and compute relativistic corrections to it. Finally, we discuss possible extensions of our results beyond perturbation theory.
Contribution of intestinal triglyceride-rich lipoproteins to residual atherosclerotic cardiovascular disease risk in individuals with type 2 diabetes on statin therapy
Authors: Taskinen Marja-Riitta , Matikainen Niina , Björnson Elias , Söderlund Sanni , Inkeri Jussi , Hakkarainen Antti , Parviainen Helka , Sihlbom Carina , Thorsell Annika , Andersson Linda , Adiels Martin , Packard Chris J. , Borén Jan 
Published: September 2023

Abstract
Aims/hypothesis
This study explored the hypothesis that significant abnormalities in the metabolism of intestinally derived lipoproteins are present in individuals with type 2 diabetes on statin therapy. These abnormalities may contribute to residual CVD risk.

Methods
To investigate the kinetics of ApoB-48- and ApoB-100-containing lipoproteins, we performed a secondary analysis of 11 overweight/obese individuals with type 2 diabetes who were treated with lifestyle counselling and on a stable dose of metformin who were from an earlier clinical study, and compared these with 11 control participants frequency-matched for age, BMI and sex. Participants in both groups were on a similar statin regimen during the study. Stable isotope tracers were used to determine the kinetics of the following in response to a standard fat-rich meal: (1) apolipoprotein (Apo)B-48 in chylomicrons and VLDL; (2) ApoB-100 in VLDL, intermediate-density lipoprotein (IDL) and LDL; and (3) triglyceride (TG) in VLDL.

Results
The fasting lipid profile did not differ significantly between the two groups. Compared with control participants, in individuals with type 2 diabetes, chylomicron TG and ApoB-48 levels exhibited an approximately twofold higher response to the fat-rich meal, and a twofold higher increment was observed in ApoB-48 particles in the VLDL1 and VLDL2 density ranges (all p < 0.05). Again comparing control participants with individuals with type 2 diabetes, in the latter, total ApoB-48 production was 25% higher (556 ± 57 vs 446 ± 57 mg/day; p < 0.001), conversion (fractional transfer rate) of chylomicrons to VLDL was around 40% lower (35 ± 25 vs 82 ± 58 pools/day; p=0.034) and direct clearance of chylomicrons was 5.6-fold higher (5.6 ± 2.2 vs 1.0 ± 1.8 pools/day; p < 0.001). During the postprandial period, ApoB-48 particles accounted for a higher proportion of total VLDL in individuals with type 2 diabetes (44%) compared with control participants (25%), and these ApoB-48 VLDL particles exhibited a fivefold longer residence time in the circulation (p < 0.01). No between-group differences were seen in the kinetics of ApoB-100 and TG in VLDL, or in LDL ApoB-100 production, pool size and clearance rate. As compared with control participants, the IDL ApoB-100 pool in individuals with type 2 diabetes was higher due to increased conversion from VLDL2.

Conclusions/interpretation
Abnormalities in the metabolism of intestinally derived ApoB-48-containing lipoproteins in individuals with type 2 diabetes on statins may help to explain the residual risk of CVD and may be suitable targets for interventions.

Trial registration
ClinicalTrials.gov NCT02948777.

Graphical Abstract
Analysing Industry 4.0 technology-solution dependencies: a support framework for successful Industry 4.0 adoption in the product generation process
Authors: Guertler Matthias R. , Schneider David , Heitfeld Justus , Sick Nathalie 
Published: September 2023

AbstractIndustry 4.0 (i4.0) is central to advanced manufacturing. Building on novel digital technologies, it enables smart and flexible manufacturing with systems connected across company boundaries and product lifecycle phases. Despite its benefits, the adoption of i4.0 has been limited, especially in small and medium-sized enterprises. A key challenge is the technological complexity of i4.0. While advanced functionality requires technological complexity, it complicates an understanding of which enabling technologies are particularly useful and required. This article presents a framework to support successful i4.0 adoption across the entire product generation process through a systematic matrix-based dependency analysis of i4.0 solutions and underlying i4.0 technologies. Through increasing transparency around technological complexity of i4.0 solutions, this research contributes to a better understanding of which technologies are required for specific i4.0 solutions and which technologies could be strategic enablers for a broad variety of i4.0 applications. Knowing these technological dependencies supports both, the systematic adoption of existing i4.0 solutions and the development of new i4.0 solutions. This also sets the basis for a future socio-technical investigation.
Neglect dyslexia: whole-word and within-word errors with parafoveal and foveal viewing
Authors: Rich Timothy J. , Palmer John 
Published: September 2023

AbstractPatients with left-sided neglect dyslexia often omit whole words positioned on the left, termed whole-word errors, or commit errors on the left-sided letters of words, termed unilateral paralexias. In addition, the errors have been shown to be exacerbated by simultaneously presented distractors, which has been interpreted as a failure of selective attention. In two experiments, we examined the dependency of these error types on parafoveal versus foveal viewing. The first experiment used a paradigm with parafoveal targets and distractors; the second a paradigm with foveal targets and parafoveal distractors. This enabled a separate evaluation of the influences of stimulus position within an egocentric frame, a two-word allocentric frame, and a within-word allocentric frame. First, regarding whole-word errors, we found the expected spatial and distractor effects with parafoveal targets and distractors. With foveal targets and parafoveal distractors, however, the spatial effect was effectively eliminated. Surprisingly, intrusions from the distractor word were common in distractor conditions. This is consistent with an egocentric account and not a two-word allocentric account. Second, we found that unilateral paralexias remained largely consistent regardless of spatial position or the presence of a distractor. Thus, there is a contrast in spatial and distractor effects between whole-word errors and unilateral paralexias. These results are consistent with three distinct deficits: an egocentric deficit across space resulting in whole-word errors, a failure of selective attention that results in whole-word intrusion errors, and a within-word allocentric deficit resulting in unilateral paralexias.
Use of ionizing radiation in a Norwegian cohort of children with congenital heart disease: imaging frequency and radiation dose for the Health Effects of Cardiac Fluoroscopy and Modern Radiotherapy in Pediatrics (HARMONIC) study
Authors: Afroz Susmita , Østerås Bjørn H. , Thevathas Utheya S. , Dohlen Gaute , Stokke Caroline , Robsahm Trude E. , Olerud Hilde M. 
Published: September 2023

Abstract
Background
The European-funded Health Effects of Cardiac Fluoroscopy and Modern Radiotherapy in Pediatrics (HARMONIC) project is a multicenter cohort study assessing the long-term effects of ionizing radiation in patients with congenital heart disease. Knowledge is lacking regarding the use of ionizing radiation from sources other than cardiac catheterization in this cohort.

Objective
This study aims to assess imaging frequency and radiation dose (excluding cardiac catheterization) to patients from a single center participating in the Norwegian HARMONIC project.

Materials and methods
Between 2000 and 2020, we recruited 3,609 patients treated for congenital heart disease (age < 18 years), with 33,768 examinations categorized by modality and body region. Data were retrieved from the radiology information system. Effective doses were estimated using International Commission on Radiological Protection Publication 60 conversion factors, and the analysis was stratified into six age categories: newborn; 1 year, 5 years, 10 years, 15 years, and late adolescence.

Results
The examination distribution was as follows: 91.0% conventional radiography, 4.0% computed tomography (CT), 3.6% diagnostic fluoroscopy, 1.2% nuclear medicine, and 0.3% noncardiac intervention. In the newborn to 15 years age categories, 4–12% had ≥ ten conventional radiography studies, 1–8% underwent CT, and 0.3–2.5% received nuclear medicine examinations. The median effective dose ranged from 0.008–0.02 mSv and from 0.76–3.47 mSv for thoracic conventional radiography and thoracic CT, respectively. The total effective dose burden from thoracic conventional radiography ranged between 28–65% of the dose burden from thoracic CT in various age categories (40% for all ages combined). The median effective dose for nuclear medicine lung perfusion was 0.6–0.86 mSv and for gastrointestinal fluoroscopy 0.17–0.27 mSv. Because of their low frequency, these procedures contributed less to the total effective dose than thoracic radiography.

Conclusion
This study shows that CT made the largest contribution to the radiation dose from imaging (excluding cardiac intervention). However, although the dose per conventional radiograph was low, the large number of examinations resulted in a substantial total effective dose. Therefore, it is important to consider the frequency of conventional radiography while calculating cumulative dose for individuals. The findings of this study will help the HARMONIC project to improve risk assessment by minimizing the uncertainty associated with cumulative dose calculations.

Graphical Abstract
Sentinel lymph node detection in thyroid carcinoma using [68Ga]Ga-tilmanocept PET/CT: a proof-of-concept study
Authors: de Vries Lisa H. , Lodewijk Lutske , Ververs Tessa , Poot Alex J. , van Rooij Rob , Brosens Lodewijk A. A. , de Krijger Ronald R. , Rinkes Inne H. M. Borel , Vriens Menno R. , de Keizer Bart 
Published: September 2023

Abstract
Purpose
Sentinel lymph node (SLN) biopsy is rarely used for thyroid carcinoma staging. This is due to challenges associated with conventional Tc-99m-labeled tracers, often producing a large hotspot at the injection site, potentially hiding nearby SLNs (shine-through effect). The aim of this study was to demonstrate the feasibility and effectiveness of SLN visualization using the new PET tracer [68Ga]Ga-tilmanocept.

Methods
Patients with thyroid carcinoma underwent ultrasound-guided peritumoral injection of [68Ga]Ga-tilmanocept and ICG-[99mTc]Tc-nanocolloid. [68Ga]Ga-tilmanocept PET/CT scans were conducted at 15 min and 60 min post-injection to visualize the SLNs. SLN biopsy was performed using ICG-[99mTc]TC-nanocolloid for intraoperative identification. The corresponding lymph node level was resected for reference.

Results
Seven differentiated thyroid carcinoma (DTC) and 3 medullary thyroid carcinoma (MTC) patients were included, of which 6 were clinically node-negative. The median number of SLNs detected on [68Ga]Ga-tilmanocept PET/CT and resected was 3 (range 1–4) and 3 (range 1–5), respectively. Eight SLNs were found on PET/CT in the central compartment and 19 in the lateral compartment. The SLN procedure detected (micro)metastases in all patients except one. Seventeen of 27 pathologically assessed SLNs were positive, 8 negative, and 2 did not contain lymph node tissue, which led to upstaging in 5 out of 6 clinically node-negative patients.

Conclusions
[68Ga]Ga-tilmanocept PET/CT identified SLNs in all patients, mainly in the lateral neck. The SLNs were successfully surgically detected and resected using ICG-[99mTc]Tc-nanocolloid. This technique has the potential to improve neck staging, enabling more personalized treatment of thyroid cancer according to the lymph node status.

Trial registration
2021–002470-42 (EudraCT).
Inclusive Environmental Decision-making in a Developing Nation: Insights from the Ogoni Remediation Project, Niger Delta, Nigeria
Authors: Sam Kabari , Zibima Tubodenyefa 
Published: September 2023

AbstractGreater involvement of women is globally believed to enhance environmental management outcomes. Despite being disproportionately affected by environmental degradation primarily caused by oil spills in the Niger Delta region of Nigeria, women in the region are often excluded in environmental decision-making processes. Women involved in farming and fishing face increased vulnerability to contaminated land, food insecurity and conflicts driven by environmental degradation. Using a mixed approach, women, lawmakers, policymakers, regulators, civil society organizations, environmental management practitioners, and government agents responsible for environmental remediation were engaged through interviews, focus group discussions and questionnaires to examine women’s inclusion in environmental decision-making and governance in the Ogoni contaminated land remediation project in the Niger Delta region of Nigeria. The results indicate that lack of trust and confidence in drivers of the environmental decision-making process could affect women’s participation and involvement in environmental management. Although cultural beliefs and practices impede the participation of women in the region, their actual participation does not independently translate into inclusion in environmental decision-making due to limited capacity, confidence and trust in the process. Creating platforms for capacity building, developing gender policy, adapting appropriate communication strategies, initiating women networks and strengthening social cohesion could enhance women involvement in environmental decision-making in regions with similar cultural context to the Niger Delta region.
Use of prescribed analgesics before and after exercise therapy and patient education in patients with knee or hip osteoarthritis
Authors: Johansson Melker S. , Pottegård Anton , Søndergaard Jens , Englund Martin , Grønne Dorte T. , Skou Søren T. , Roos Ewa M. , Thorlund Jonas B. 
Published: September 2023

AbstractThe aim of this study was to investigate utilisation patterns of prescribed analgesics before, during, and after an exercise therapy and patient education program among patients with knee or hip osteoarthritis. This cohort study is based on data from the nationwide Good Life with osteoarthritis in Denmark (GLA:D®) patient-register linked with national health registries including data on prescribed analgesics. GLA:D® consists of 8–12 weeks of exercise and patient education. We included 35,549 knee/hip osteoarthritis patients starting the intervention between January 2013 and November 2018. Utilisation patterns the year before, 3 months during, and the year after the intervention were investigated using total dispensed defined daily doses (DDDs) per month per 1000 population as outcome. During the year before the intervention, use of prescribed paracetamol, non-steroidal anti-inflammatory drugs (NSAIDs), and opioids increased with 85%, 79% and 22%, respectively. During the intervention, use of paracetamol decreased with 16% with a stable use the following year. Use of NSAIDs and opioids decreased with 38% and 8%, respectively, throughout the intervention and the year after. Sensitivity analyses indicated that the prescription of most analgesics changed over time. For paracetamol, NSAIDs, and opioids, 10% of analgesic users accounted for 45%, 50%, and 70%, respectively, of the total DDDs dispensed during the study period. In general, analgesic use increased the year before the intervention followed by a decrease during the intervention and the year after. A small proportion of analgesic users accounted for half or more of all paracetamol, NSAIDs, and opioids dispensed during the study period.
On strongly dependent zero-inflated INAR(1) processes
Authors: Beran Jan , Droullier Frieder 
Published: September 2023

AbstractWe consider INAR(1) processes modulated by an unobserved strongly dependent $$0-1$$

0
-
1

process. The observed process exhibits zero inflation and long memory. A simple method is proposed for estimating the INAR-parameters without modelling the unobserved modulating process. Asymptotic results for the estimators are derived, and a zero-inflation test is introduced. Asymptotic rejection regions and asymptotic power under long-memory alternatives are derived. A small simulation study illustrates the asymptotic results.
Maximum Likelihood With a Time Varying Parameter
Authors: Lanconelli Alberto , Lauria Christopher S. A. 
Published: September 2023

AbstractWe consider the problem of tracking an unknown time varying parameter that characterizes the probabilistic evolution of a sequence of independent observations. To this aim, we propose a stochastic gradient descent-based recursive scheme in which the log-likelihood of the observations acts as time varying gain function. We prove convergence in mean-square error in a suitable neighbourhood of the unknown time varying parameter and illustrate the details of our findings in the case where data are generated from distributions belonging to the exponential family.
Fast rendering of central and peripheral human visual aberrations across the entire visual field with interactive personalization
Authors: Csoba István , Kunkli Roland 
Published: September 2023

AbstractWith the recent progress made in areas such as head-mounted displays and vision-correcting devices, there is a growing interest in fast and personalized algorithms for simulating aberrated human vision. Existing vision-simulating approaches are generally hindered by the lack of personalization, computational cost of rendering, and limited types of supported aberrations. This paper presents a fast vision simulation method with interactive personalization capabilities for simulating arbitrary central and peripheral aberrations of the human eye. First, we describe a novel, neural network-based solution for efficiently estimating the physical structure of the simulated eye and calculating the necessary Zernike aberration coefficients for computing the point-spread functions with varying pupil sizes, focus distances, and incidence angles. Our new approach operates in the sub-second regime and produces highly accurate outputs, facilitating the interactive personalization of vision simulation. Next, we present an improved PSF interpolation method for an existing tiled PSF splatting algorithm for rendering. The proposed algorithm significantly improves the computational performance and memory efficiency of the previous approach, allowing the simulation of peripheral vision with arbitrary visual aberrations in low-latency applications. Following the description of our new techniques, we evaluate their performance characteristics and simulation accuracies on several different eye conditions and test scenarios and compare our results to several previous vision simulation algorithms.
Effects of reversible SERCA inhibition on catecholamine exocytosis and intracellular [Ca2+] signaling in chromaffin cells from normotensive Wistar Kyoto rats and spontaneously hypertensive rats
Authors: Parada-Parra Oscar J. , Hernández-Cruz Arturo 
Published: September 2023

AbstractIntracellular Ca2+ ([Ca2+]i) signaling and catecholamine (CA) exocytosis from adrenal chromaffin cells (CCs) differ between mammalian species. These differences partly result from the different contributions of Ca2+-induced Ca2+-release (CICR) from internal stores, which boosts intracellular Ca2+ signals. Transient inhibition of the sarcoendoplasmic reticulum (SERCA) Ca2+ pump with cyclopiazonic acid (CPA) reduces CICR. Recently, Martínez-Ramírez et al. found that CPA had contrasting effects on catecholamine secretion and intracellular Ca2+ signals in mouse and bovine CCs, where it enhanced and inhibited exocytosis, respectively. After CPA withdrawal, exocytosis diminished in mouse CCs and increased in bovine CCs. These differences can be explained if mouse CCs have weak CICR and strong Ca2+ uptake, and the reverse is true for bovine CCs. Surprisingly, CPA slightly reduced the amplitude of Ca2+ signals in both mouse and bovine CCs. Here we examined the effects of CPA on stimulated CA exocytosis and Ca2+ signaling in rat CCs and investigated if it alters differently the responses of CCs from normotensive (WKY) or hypertensive (SHR) rats, which differ in the gain of CICR. Our results demonstrate that CPA application strongly inhibits voltage-gated exocytosis and Ca2+ transients in rat CCs, regardless of strain (SHR or WKY). Thus, despite the greater phylogenetic distance from the most recent common ancestors, suppression of endoplasmic reticulum (ER) Ca2+ uptake through CPA inhibits the CA secretion in rat CCs more similarly to bovine than mouse CCs, unveiling divergent evolutionary relationships in the mechanism of CA exocytosis of CCs between rodents. Agents that inhibit the SERCA pump, such as CPA, suppress catecholamine secretion equally well in WKY and SHR CCs and are not potential therapeutic agents for hypertension. Rat CCs display Ca2+ signals of varying widths. Some even show early and late Ca2+ components. Narrowing the Ca2+ transients by CPA and ryanodine suggests that the late component is mainly due to CICR. Simultaneous recordings of Ca2+ signaling and amperometry in CCs revealed the existence of a robust and predictable correlation between the kinetics of the whole-cell intracellular Ca2+ signal and the rate of exocytosis at the single-cell level.