bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effectiveness of Yoga Movements in Reducing the Pain of Dysmenorrhea in Adolescent Women in SMAN 1 Tambang
Authors: Nia Desriva  , Ary Oktora Sri Rahayu  , Tukimin  
Published: February 2023

Menstrual pain or dysmenorrhea is defined as pain that occurs before or during a menstrual period, this pain may last from one to several days. Dysmenorrhea is menstrual pain that is often complained of by women, which is characterized by brief pain before or during menstruation (Lowdermilk et al., 2011). There are many ways to reduce dysmenorrhea pain, one of which is yoga. Yoga helps the body's endocrine glands function better, and when done for at least 30 seconds during your period, it can help relieve dysmenorrhea and facilitate menstruation. The purpose of this study was to analyze the effectiveness of yoga movements in reducing dysmenorrhea pain.The research design was pre-experimental designs, using one group pre-test and post-test. Samples are taken by technique purposive samplings many as 24 respondents. Data were analyzed univariately and bivariately using the Wilcoxon Signed Rank test. Univariate results before doing yoga results obtained most of the students experienced pain on average on a scale of 4, namely 11 respondents (45%) and on a pain scale of 3, namely 7 female students (29%). female students (62%). The bivariate results obtained that there was an effect of yoga movement on dysmenorrhea pain in young women at SMAN 1 Tambang with a p value of 0.000. It was concluded that there is effectiveness of yoga movements in relieving dysmenorrhea pain and there are significant differences between before and after doing yoga movements. It is recommended that young women do yoga regularly to relieve dysmenorrhea pain.
TUHAN, IZINKAN AKU BERNYANYI: ROCKER MUSLIMAH SUNDA DAN RESISTENSI TERHADAP STEREOTYPE
Authors: Noorbani Muhammad Agus , Nur Mahmudah 
Published: February 2023

This paper provides an analysis of resistance carried out by a rock band called Voice of Baceprot (VoB). VoB is a group of heavy metal musicians consisting of three young Sundanese Muslimah from Garut, Indonesia. Sundanese women are usually portrayed as having ambiguous characteristics, especially as depicted in the media. Physically, they are often perceived as attractive and ageless, while their personality traits are considered hard-working, assertive, principled, smart, and trustworthy. These perceptions thus create a negative stereotype of Sundanese women, especially since it is still taboo for muslim women to do rock music. This article aims to explain how these young Sundanese muslimah resist and negotiate their freedom as expressed through heavy metal music. Content analysis is used to analyze the data, such as the interview and the lyrics of their songs. The result shows that the values of religion still prevent women, especially young women, to pursue a career in arts. How VoB fight for freedom is not driven in a frontal and disruptive way, but they use their own vulnerability as their resistance. Through the lyrics, the way they dress, and how they express themself in the media, these young women show that freedom will never oppose from being shari’a muslim.
Hubungan persepsi pasangan usia subur (PUS) berkebutuhan khusus dengan pelayanan antenatal pada komunitas umbrella disability project kota Bukittinggi
Authors: Andriani Liza , Andri Rantih Fadhlya , Zalukhu Aze Renata Fenzelina 
Published: January 2023

Berdasarkan Undang-Undang Nomor 19 Tahun 2011 tentang Pengesahan Konvensi Hak-Hak Penyandang Disabilitas khusunya Pasal 25 bahwa mereka mempunyai hak untuk mendapatkan jaminan kesehatan. Ketidakmampuan perempuan disabilitas untuk menjadi seorang ibu, menyebabkan mereka enggan untuk melakukan kunjungan antenatal.Selain itu faktor komunikasi ketika memberikan pendidikan kesehatan tentang kehamilan menjadikan pelayanan antenatal tidak berkualitas sehingga mereka mempunyai persepsi dan tingkat kepuasan yang kurang baik terhadap pelayanan kebidanan. Penelitian ini bertujuan untuk mengetahui hubungan persepsi PUS Berkebutuhan Khusus dengan Pelayanan Antenatal pada Komunitas Umbrella Disability Project Kota Bukittinggi. Jenis penelitian bersifat deskriptif kuantitatif. Populasi adalah seluruh PUS yang berada di komunitas disabilitas sebanyak 12 orang dan pengambilan sample dilakukan secara total sampling. Pengumpulan data dilakukan pada bulan Agustus 2022 dengan teknik wawancara menggunakan kuesioner dan observasi. Saat melakukan wawancara, peneliti didampingi oleh pengurus komunitas UDP sebagai translator. Hasil penelitian didapatkan bahwa lebih dari setengah (58.3 %) responden memiliki tingkat pendidikan tamat SMA, lebih dari setengah (66.7%) memperoleh pelayanan antenatal care, dan lebih dari setengah (58.7%) mempunyai persepsi yang baik tentang pelayanan Antenatal Care. setelah dilakukan uji analitik Chi-Square didapatkan bahwa ada hubungan bermakna antara persepsi PUS berkebutuhan khusus dengan pelayanan antenatal di komunitas UDP Kota Bukittinggi (p value 0,05). Berdasarkan asumsi peneliti, faktor komunikasi yang informatif paling berpengaruh dalam memberikan kepuasan dan persepsi yang baik terhadap pelayanan kehamilan pada perempuan difable yaitu dengan didampingi oleh keluarga atau suami.
Pengaruh Penambahan Abu Tandan Kelapa Sawit Terhadap Daya Dukung Tanah Lempung
Authors: Fitramsya Sendi , Pujiastutie Elly Tri 
Published: February 2023

ABSTRACT
One of the most important material that has great impat to a structure or onstrution in civil engineering job is soil, either that job is building or road pavement construction. One of problem which may happen faced by consultant or contractor ( especially for road pavement construction ) is take care of soil and other bad component to make sure those components can be used as ingredient for that pavement construction. Thing can be done to fix the mechanic property in this research is by using chemical way like adding oil palm ‘s stem ashes with 0%, 6,5%, 7%, 8%, and 8,5 % variation from clay. Biggest CBR value happen when 0,2 penetration with CBR value was 18,078% by using 8,5 % oil palm’s stem addictive. This value has increased by 2,288 % from the CBR value from the original soil which is 15,790%. With adding 6,5% oil palm’s stem ashes the CBR value increased 0,703%, when adding 7% increased by 0,273% and also when adding 8% increased 1,168%. This CBR value qualified Bina Marga 2018 general specification ( Third revision ) where CBR value > 6%.
Higher Education Practitioners' Experience in a Global Pandemic
Authors: Laird Chelsey 
Published: January 2023

I write this reflection from my perspective as an international education practitioner and administrator, but also as a doctoral student in the Faculty of Education at Simon Fraser University. The intersection of these identities presents a perspective that is informed by my lived reality of what internationalization of higher education is, in the Canadian context. It is this space, between theory and practice of internationalization of higher education, where my research interests lie. I am specifically focused on the experience of higher education staff members. This is of particular interest in the current context of the COVID-19 pandemic and its impact on the internationalization of higher education.
Perancangan Aplikasi Android Untuk Memonitoring Salinitas dan Suhu Air Aquarium pada Budidaya Ikan Badut
Authors: Sahnah Malika , Rafsyam Yenniwarti 
Published: February 2023

Ikan badut merupakan ikan yang banyak dibudayakan oleh petani pada aquarium. Dalam pembudidayaannya, terdapat beberapa parameter yang perlu diperhatikan, yaitu kadar salinitas air berkisar 29 PPT - 37 PPT dan suhu air beriksar 25°C-30°C. Untuk memudahkan dalam pemantauan salinitas dan suhu pada aquarium, maka dibuatlah Aplikasi NEMOKU untuk sistem monitoring dan kontrol jarak jauh salinitas dan suhu air melalui Aplikasi Android, yang terhubung dengan sistem pengontrol berupa heater aquarium, serta pompa air tawar dan air garam. Aplikasi NEMOKU memiliki sistem monitoring secara otomatis dan manual. Pada sistem manual, petani ikan mengakitfkan sistem memalui aplikasi, sesuai dengan kondisi pada aquarium. Apabila salinitas <29 PPT, petani mengaktifkan pompa air garam, jika nilai salinitas >37 PPT, mengaktifkan pompa air tawar dan apabila suhu <25°C, mengaktifkan heater aquarium. Pada sistem otomatis, sistem akan otomatis aktif untuk menjaga salinitas dan suhu pada aquarium. Dari pengujian yang dilakukan, sistem yang dirancang sudah bekerja baik dalam mengirimkan data salinitas dan suhu serta melakukan kontrol jarak jauh. Spesifikasi alat yang digunakan untuk aplikasi yang dibuat menggunakan software Android Studio Version Bumblebee, laptop dengan processor Intel® Core TM i3 2370 M CPU @ 2.8 GHz, Memory 4 GB, Harddisk 500 GB dan Monitor 14 inches.
Assembly of a Fab1 phosphoinositide kinase signaling complex requires the Fig4 phosphoinositide phosphatase
Authors: Botelho Roberto , Efe Jem A. , Teis David , Emr Scott D. 
Published: January 2023

<p> </p>
<p>Phosphatidylinositol-3,5-bisphosphate [PtdIns(3,5)P(2)] regulates several vacuolar functions, including acidification, morphology, and membrane traffic. The lipid kinase Fab1 converts phosphatidylinositol-3-phosphate [PtdIns(3)P] to PtdIns(3,5)P(2). PtdIns(3,5)P(2) levels are controlled by the adaptor-like protein Vac14 and the Fig4 PtdIns(3,5)P(2)-specific 5-phosphatase. Interestingly, Vac14 and Fig4 serve a dual function: they are both implicated in the synthesis and turnover of PtdIns(3,5)P(2) by an unknown mechanism. We now show that Fab1, through its chaperonin-like domain, binds to Vac14 and Fig4 and forms a vacuole-associated signaling complex. The Fab1 complex is tethered to the vacuole via an interaction between the FYVE domain in Fab1 and PtdIns(3)P on the vacuole. Moreover, Vac14 and Fig4 bind to each other directly and are mutually dependent for interaction with the Fab1 kinase. Our observations identify a protein complex that incorporates the antagonizing Fab1 lipid kinase and Fig4 lipid phosphatase into a common functional unit. We propose a model explaining the dual roles of Vac14 and Fig4 in the synthesis and turnover of PtdIns(3,5)P(2).</p>
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pH of endophagosomes controls association of their membranes with Vps34 and PtdIns(3)P levels
Authors: Naufer Amriya , Hipolito Victoria E. B. , Ganesan Suriakarthiga , Prashar Akriti , Zaremberg Vanina , Botelho Roberto , R. Terebiznik Mauricio 
Published: January 2023

<p>Phagocytosis of filamentous bacteria occurs through tubular phagocytic cups (tPCs) and takes many minutes to engulf these filaments into phagosomes. Contravening the canonical phagocytic pathway, tPCs mature by fusing with endosomes. Using this model, we observed the sequential recruitment of early and late endolysosomal markers to the elongating tPCs. Surprisingly, the regulatory early endosomal lipid phosphatidylinositol-3-phosphate (PtdIns(3)P) Persists on tPCs as long as their luminal pH remains neutral. Interestingly, by manipulating cellular pH, we determined that PtdIns(3) P behaves similarly in canonical phagosomes as well as endosomes. We found that this is the product of a pH-based mechanism that induces the dissociation of the Vps34 class III phosphatidylinositol-3-kinase from these organelles as they acidify. The detachment of Vps34 stops the production of PtdIns(3)P, allowing for the turnover of this lipid by PIKfyve. Given that PtdIns(3)P-dependent signaling is important for multiple cellular pathways, this mechanism for pH-dependent regulation of Vps34 could be at the center of many PtdIns(3)P-dependent cellular processes. </p>
Multiscale interactome analysis coupled with off‑target drug predictions reveals drug repurposing candidates for human coronavirus disease
Authors: G. Sugiyama Michael , Cui Haotian , Redka Dar’ya
S. , Karimzadeh Mehran , Rujas Edurne , Maan Hassaan , Hayat Sikander , Cheung Kyle , Misra Rahul , McPhee Joseph , Viirre Russell , Haller Andrew , Botelho Roberto , Karshafian Raffi , Sabatinos Sarah , Fairn Gregory D. , Tonekaboni Seyed Ali Madani , Windemuth Andreas , Julien Jean-Philippe , Shahani Vijay , MacKinnon Stephen S. , Wang Bo , N. Antonescu Costin 
Published: January 2023

<p> </p>
<p>The COVID-19 pandemic has highlighted the urgent need for the identification of new antiviral drug therapies for a variety of diseases. COVID-19 is caused by infection with the human coronavirus SARS-CoV-2, while other related human coronaviruses cause diseases ranging from severe respiratory infections to the common cold. We developed a computational approach to identify new antiviral drug targets and repurpose clinically-relevant drug compounds for the treatment of a range of human coronavirus diseases. Our approach is based on graph convolutional networks (GCN) and involves multiscale host-virus interactome analysis coupled to off-target drug predictions. Cell-based experimental assessment reveals several clinically-relevant drug repurposing candidates predicted by the in silico analyses to have antiviral activity against human coronavirus infection. In particular, we identify the MET inhibitor capmatinib as having potent and broad antiviral activity against several coronaviruses in a MET-independent manner, as well as novel roles for host cell proteins such as IRAK1/4 in supporting human coronavirus infection, which can inform further drug discovery studies.</p>
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Inhibition of lipid kinase PIKfyve reveals a role for phosphatase Inpp4b in the regulation of PI(3)P-mediated lysosome dynamics through VPS34 activity
Authors: Saffi Golam T. , Wang Cheng An , Mangialardi Emily M. , Vacher Jean , Salmena Leonardo , Botelho Roberto 
Published: January 2023

<p>Lysosome membranes contain diverse phosphoinositide (PtdIns) lipids that coordinate lysosome function and dynamics. The PtdIns repertoire on lysosomes is tightly regulated by the actions of diverse PtdIns kinases and phosphatases; however, specific roles for PtdIns in lysosomal functions and dynamics are currently unclear and require further investigation. It was previously shown that PIKfyve, a lipid kinase that synthesizes PtdIns(3,5)P2 from PtdIns(3)P, controls lysosome “fusion-fission” cycle dynamics, autophagosome turnover, and endocytic cargo delivery. Furthermore, INPP4B, a PtdIns 4-phosphatase that hydrolyzes PtdIns(3,4)P2 to form PtdIns(3)P, is emerging as a cancer-associated protein with roles in lysosomal biogenesis and other lysosomal functions. Here, we investigated the consequences of disrupting PIKfyve function in <em>Inpp4b</em>-deficient mouse embryonic fibroblasts. Through confocal fluorescence imaging, we observed the formation of massively enlarged lysosomes, accompanied by exacerbated reduction of endocytic trafficking, disrupted lysosome fusion-fission dynamics, and inhibition of autophagy. Finally, HPLC scintillation quantification of 3H-<em>myo-</em>inositol labeled PtdIns and PtdIns immunofluorescence staining, we observed that lysosomal PtdIns(3)P levels were significantly elevated in <em>Inpp4b</em>-deficient cells due to the hyperactivation of phosphatidylinositol 3-kinase catalytic subunit VPS34 enzymatic activity. In conclusion, our study identifies a novel signaling axis that maintains normal lysosomal homeostasis and dynamics, which includes the catalytic functions of Inpp4b, PIKfyve, and VPS34.</p>
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MICAL2 ﬁne-tunes Arp2/3 for actin branching
Authors: Olson Michael , Machesky Laura M. 
Published: January 2023

<p>The ARP2/3 complex promotes branched actin networks, but the importance of specific subunit isoforms is unclear. In this issue, Galloni, Carra, et al. (2021. J. Cell Biol. https://doi.org/10.1083/jcb.202102043) show that MICAL2 mediates methionine oxidation of ARP3B, thus destabilizing ARP2/3 complexes and leading to disassembly of branched actin filaments. </p>
Bahan Ajar Berbasis Karakter Cerita Rakyat Untuk Pembelajaran Bahasa Indonesia di SD
Authors: Dadang Cunandar  , Dhia Zulfa Khaerunnisa  , Atang Sutisna  
Published: February 2023

Penelitian ini bertujuan; (1) Menjelaskan Unsur Intrinsik Cerita Rakyat Kecamatan Cibingbin; (2) Menjelaskan Nilai Karakter Cerita Rakyat Kecamatan Cibingbin; (3) Menjelaskan Design Bahan Ajar Sastra Berbasis Karakter dalam Cerita Rakyat untuk Pembelajaran Bahasa Indonesia di Sekolah Dasar; (4) Menjelaskan Kesesuaian Bahan Ajar Sastra Berbasis Karakter Cerita Rakyat untuk Pembelajaran Bahasa Indonesia di Sekolah Dasar. Metode penelitian menggunakan Metode Deskriptif dengan pendekatan kualitatif. Sumber data penelitian adalah tokoh masyarakat, dan ahli. Lokasi penelitian di Kecamatan Cibingbin. Teknik pengumpulan data menggunakan Pengamatan, Wawancara, dan dokumentasi. Analisis data yang digunakan adalah Reduksi Data, Penyajian Data, dan Kesimpulan/Verifikasi. Hasil penelitian 1) Unsur instrinsik dalam cerita rakyat Kecamatan Cibingbin antara lain, tema, tokoh, penokohan, alur, setting dan amanat. 2) Karakter Religius, jujur, kerja keras, dan tanggung jawab. 3) Bahan ajar yang dibuat oleh peneliti berupa bahan ajar cetak. 4) Bahan ajar berbasis karakter cerita rakyat telah memenuhi kesesuaian dan kelayakan
Pengaruh Media Massa dan Literasi Media Terhadap Komunikasi Sosialisasi Covid - 19 dari Pemerintah Indonesia
Authors: Kristina Della , Gantiano Hadianto Ego 
Published: February 2023

Pada artikel ini akan membahas lebih jauh tentang bagaimana dan apa yang dapat menjadi solusi dari pandemi covid -19 pun juga masih sangat gamang untuk diketahui, dikarenakan kondisi dan fenomena yang terjadi sekarang ini yang walaupun sudah dapat terprediksi oleh para ahli, masih akan tetap sulit untuk dikendalikan. Sosialisasi atau pemberian informasi tentang covid – 19 merupakan salah satu hal yang sangat vital yang harus diketahui oleh pemerintah Indonesia, dikarenakan hal ini merupakan upaya pencegahan paling awal yang dapat dilakukan agar masyarakat Indonesia memahami bagaimana harusnya yang mereka dapat lakukan dalam hidup berdampingan dengan covid. Oleh karena itu, pemerintah membentuk juru bicara khusus dalam rangka menjalin relasi melalui komunikasi dengan masyarakat dalam penyampaian isu – isu covid - 19, hal ini juga menunjukkan pentingnya posisi langkah awal tersebut terhadap bagaimana implikasi covid – 19 bagi Indonesia kedepannya. Dalam hal ini, pemerintah tentunya membutuhkan media atau perantara antara pihak pemberi informasi yaitu pemerintah itu sendiri, terhadap pihak penerima informasi atau yang dalam hal ini adalah masyarakat. Disinilah media massa berperan dengan cukup besar terhadap proses relasi ini. Mengingat bagaimana media massa hingga sekarang merupakan salah satu sumber dalam mencari atau mendapatkan informasi bagi masyarakat. Namun, apakah pemanfaatan dan pemakaian dari media sudah baik? Terutama dalam bagaimana masyarakat yang dianggap sebagai “ goals “ atau tujuan dari proses komunikasi dalam penyampaian sosialisai tersebut, menerima dan memproses informasi atau pesan yang didapat melalui media yang ada atau yang biasa disebut sebagai literasi media.
Peran Penyuluh Agama Hindu Dalam Pendidikan Karakter Generasi Muda Di Kabupaten Barito Selatan
Authors: M.Pd Melky Setiawan 
Published: February 2023

The moral crisis is no longer a simple case but has serious consequences for the students, meanwhile to build a developed country it is necessary to have a young generation with noble character and character. This personality case can be seen from the existence of student brawls, juvenile delinquency, crime among young people, and so on. The phenomenon that occurs in several areas in South Barito Regency proves that this character education crisis also occurs in the region where juvenile delinquency is rampant and has entered the realm of crime.
The role of Hindu religious instructors in character education for the younger generation in South Barito Regency is to teach knowledge about religious teachings and train religious skills. To do this, Hindu religious instructors also guide and motivate the younger generation to be diligent and study hard and be involved in the activities carried out. Hindu religious instructors also set an example for the younger generation in appearance and behavior in accordance with the teachings of goodness. The role of the Hindu religious instructor is to bring about a change in the character of the young generation of Hindus in South Barito Regency for the better.
Životní úroveň v krajích České republiky – změny za dvě desetiletí jejich existence
Authors:   Univerzita Pardubice, Kadlec Adam , Kraftová Ivana ,   Univerzita Pardubice
Published: February 2023

Living standards in the regions of the Czech Republic - changes in two decades of their functioning The aim of the article is to present the changes that have occurred in the standard of living in the regions of the Czech Republic established in 2000, during their twenty years of functioning. The means for this comparative evaluation is a model in the 3*4 format, i. e. four relevant indicators in three main areas. The result of the analysis is to capture changes in the position of individual regions in each of the selected indicators, in each area of evaluation and in the overall assessment of the achieved standard of living. It shows that while the variability taken together is decreasing, this is not always the case in the individual indicators assessed. The findings presented can provide an impulse for managing the strengths and weaknesses affecting the standard of living at both the regional and national levels. URL: https://vsas.fvs.upjs.sk/
PENGARUH PERTUMBUHAN PENJUALAN, CORPORATE SOCIAL RESPONBILITY, INTENSITAS ASET TETAP, DAN INTENSITAS PERSEDIAAN TERHADAP TAX AVOIDANCE
Authors: Alif Videya Anas , Irawati Wiwit 
Published: February 2023

Penelitian ini bertujuan untuk mengetahui dan menguji secara empiris pengaruh pertumbuhan penjualan, corporate social responsibility, intensitas aset tetap, dan intensitas persediaan terhadap tax avoidance dengan studi empiris pada perusahaan indek saham LQ 45 yang terdaftar di Bursa Efek Indonesia pada tahun 2016-2020. Jenis penelitian ini adalah kuantitatif yang bersifat asosiatif. Populasi pada penelitan ini menggunakan 45 Perusahaan. Metode pengambilan sampel pada penelitian ini menggunakan metode purposive sampling sehingga diperoleh sebanyak 27 sampel perusahaan yang digunakan dalam peneltian ini. Data dalam penelitian ini menggunakan data sekunder yang di ambil dari laporan tahunan perusahaan dan laporan keuangan perusahaan sebanyak 135 data obeservasi. Untuk Teknik analisis data yang digunakan adalah analisis regresi data panel. Pengolahan data dalam penelitian ini menggunakan bantuan aplikasi Eviews 10. Hasil penelitian menunjukan bahwa variabel pertumbuhan penjualan berpengaruh signifikan terhadap tax avoidance. Corporate social responsibility berpengaruh signifikan terhadap tax avoidance. Dan intensitas persediaan berpengaruh signifikan terhadap tax avoidance. Sedangkan untuk variabel intensitas aset tetap tidak berpengaruh terhadap tax avoidance.

Kata kunci : tax avoidance, pertumbuhan penjualan, corporate social responsibility, intensitas asset tetap, intensitas persediaan