bluuebunny/crossref_metadata_2025_split huggingface dataset:
Response to electroconvulsive therapy in treatment-resistant depression: nationwide observational follow-up study
Authors: Nygren Adam , Reutfors Johan , Brandt Lena , Bodén Robert , Nordenskjöld Axel , Tiger Mikael 
Published: February 2023

Background
Previous studies have not investigated response rates after electroconvulsive therapy (ECT) in patients with non-psychotic treatment-resistant depression (TRD).

Aims
To assess and compare the response rate of ECT for patients with TRD and non-TRD, in a large and clinically representative patient sample.

Method
Patients aged ≥18 years, who were treated for a unipolar, non-psychotic depressive episode with at least one ECT session as part of a first-time, index ECT series between 1 January 2011 and 31 December 2017 were included from the Swedish National Quality Register for ECT. Patients who had initiated a third consecutive trial of antidepressants or add-on medications before start of ECT were classified as having TRD. Patients not meeting criteria for TRD were classified as non-TRD. The main outcome was response to ECT according to the Clinical Global Impressions – Improvement Scale (CGI-I), scored as 1 or 2 (‘very much’ or ‘much improved’ after ECT, respectively). Logistic regression was used to compare outcome measures between TRD and non-TRD, adjusting for potential confounders.

Results
A total of 4244 patients were included. Of these, 1121 patients had TRD and 3123 patients had non-TRD. The CGI-I response rate was 65.9% in the TRD group compared with 75.9% in the non-TRD group (adjusted odds ratio 0.64, 95% CI 0.54–0.75). Older age and more severe depression were predictors of response in patients with TRD.

Conclusions
A clear majority of patients with TRD, as well as patients with non-TRD, responded to ECT, although the response rate was somewhat lower for TRD.
Improving Uptake of Cancer Genetic Risk Assessment in a Remote Tailored Risk Communication and Navigation Intervention: Large Effect Size but Room to Grow
Authors: Kinney Anita Y. , Walters Scott T. , Lin Yong , Lu Shou-En , Kim Arreum , Ani Julianne , Heidt Emily , Le Compte Circe J.G. , O'Malley Denalee , Stroup Antoinette , Paddock Lisa E. , Grumet Sherry , Boyce Tawny W. , Toppmeyer Deborah L. , McDougall Jean A. 
Published: February 2023

PURPOSECancer genetic risk assessment (CGRA) is recommended for women with ovarian cancer or high-risk breast cancer, yet fewer than 30% receive recommended genetic services, with the lowest rates among underserved populations. We hypothesized that compared with usual care (UC) and mailed targeted print (TP) education, CGRA uptake would be highest among women receiving a phone-based tailored risk counseling and navigation intervention (TCN).METHODSIn this three-arm randomized trial, women with ovarian or high-risk breast cancer were recruited from statewide cancer registries in Colorado, New Jersey, and New Mexico. Participants assigned to TP received a mailed educational brochure. Participants assigned to TCN received the mailed educational brochure, an initial phone-based psychoeducational session with a health coach, a follow-up letter, and a follow-up navigation phone call.RESULTSParticipants' average age was 61 years, 25.4% identified as Hispanic, 5.9% identified as non-Hispanic Black, and 17.5% lived in rural areas. At 6 months, more women in TCN received CGRA (18.7%) than those in TP (3%; odds ratio, 7.4; 95% CI, 3.0 to 18.3; P < .0001) or UC (2.5%; odds ratio, 8.9; 95% CI, 3.4 to 23.5; P < .0001). There were no significant differences in CGRA uptake between TP and UC. Commonly cited barriers to genetic counseling were lack of provider referral (33.7%) and cost (26.5%), whereas anticipated difficulty coping with test results (14.0%) and cost (41.2%) were barriers for genetic testing.CONCLUSIONTCN increased CGRA uptake in a group of geographically and ethnically diverse high-risk breast and ovarian cancer survivors. Remote personalized interventions that incorporate evidence-based health communication and behavior change strategies may increase CGRA among women recruited from statewide cancer registries.
Molecular-Guided Off-Label Targeted Therapy in a Large-Scale Precision Oncology Program
Authors: Vashistha Vishal , Katsoulakis Evangelia , Guo Aixia , Price Meghan , Ahmed Sara , Kelley Michael J. 
Published: February 2023

PURPOSE Increasing utilization of comprehensive genomic profiling (CGP) and a growing number of targeted agents (TAs) have led to substantial improvements in outcomes among patients with cancer with actionable mutations. We sought to evaluate real-world experience with off-label TAs among Veterans who underwent CGP. METHODS The National Precision Oncology Program database and VA Corporate Data Warehouse were queried to identify patients who underwent CGP between February 2019 and December 2021 and were prescribed 1 of 73 TAs for malignancy. OncoKB annotations were used to select patients who received off-label TAs based upon CGP results. Chart abstraction was performed to review response, toxicities, and time to progression. RESULTS Of 18,686 patients who underwent CGP, 2,107 (11%) were prescribed a TA and 169 (0.9%) were prescribed a total of 183 regimens containing off-label TAs for variants in 31 genes. Median age was 68 years and 83% had prior systemic therapy, with 28% receiving three or more lines. Frequency of off-label TA prescriptions was highest for patients undergoing CGP for thyroid (8.6%) and breast (7.6%) cancers. Most patients harbored alterations in BRCA1/BRCA2/ATM (22.5%), ERBB2 (19.5%), and BRAF (19.5%). Among the 160 regimens prescribed > 4 weeks, 43 (27%) led to response. Median progression-free survival and overall survival were 5.3 (4.2-6.5) and 9.7 (7.5-11.9) months, respectively. Patients with OncoKB level 2/3A/3B annotations had longer median progression-free survival (5.8 [4.5-7] months v 3.7 [1.6-7.7] months; hazard ratio, 0.45; 95% CI, 0.24 to 0.82; P = .01) compared with those receiving level 4 treatments. CONCLUSION Although administration of off-label TAs is infrequent after CGP, more than one quarter of treatment regimens led to response. TAs associated with level 4 annotations lead to worse outcomes than TAs bearing higher levels of evidence.
Web-based digital twin online laboratories: Methodologies and implementation
Authors: Lei Zhongcheng , Zhou Hong , Hu Wenshan , Liu Guo-Ping 
Published: February 2023

Background: Online laboratories that provide online experimentation are crucial for education and research in all fields of engineering. As a transformative technology, the digital twin can be potentially applied into online laboratories to enable physical-digital twin interactions and enhance user experience. Methods: In this article, web-based digital twin online laboratories are discussed, the methodologies and implementation of which are presented in detail. The digital twin architecture, three-dimensional twin model, web-based digital twin control algorithm design, and real-time physical-twin control are explored to provide a full picture for the design and implementation of digital twin online laboratory systems. To illustrate the effectiveness of the proposed methodologies, a use case with the Networked Control System Laboratory (a previously developed control and automation laboratory) is provided, which details the design and implementation. Results: A four-tier web architecture has been implemented. With the provided web interface, control algorithms can be designed and employed for real-time digital twin experimentation. The experimental results demonstrated that the physical-digital twin fan speed control system can achieve good control and tracking performance with human-in-the-loop interactions. Conclusions: This article presents the methodologies and implementation of digital twin web-based online laboratories. The use case verified the proposed web architecture, digital twin implementation, control architecture, and human-in-the-loop interactions for a digital twin experimentation system, which can potentially be used for the design and implementation of other digital-twin applications in different fields.
Diameter, height and species of 42 million trees in three European landscapes generated from field data and airborne laser scanning data
Authors: Aussenac Raphaël , Monnet Jean-Matthieu , Klopčič Matija , Hawryło Paweł , Socha Jarosław , Mahnken Mats , Gutsch Martin , Cordonnier Thomas , Vallet Patrick 
Published: February 2023

Ecology and forestry sciences are using an increasing amount of data to address a wide variety of technical and research questions at the local, continental and global scales. However, one type of data remains rare: fine-grain descriptions of large landscapes. Yet, this type of data could help address the scaling issues in ecology and could prove useful for testing forest management strategies and accurately predicting the dynamics of ecosystem services. Here we present three datasets describing three large European landscapes in France, Poland and Slovenia down to the tree level. Tree diameter, height and species data were generated combining field data, vegetation maps and airborne laser scanning (ALS) data. Together, these landscapes cover more than 100~000~ha and consist of more than 42 million trees of 51 different species. Alongside the data, we provide here a simple method to produce high-resolution descriptions of large landscapes using increasingly available data: inventory and ALS data. We evaluated the overall reliability of our workflow by comparing the stands dominant heights measured by ALS to those calculated from the trees we generated. Overall, the landscapes we generated are in good agreement with the landscapes they aim to reproduce.
The Activities of Local Government Municipal Units in Shaping Inclusive Education in Poland
Authors: Skotnicka Beata , Mrózek Sebastian 
Published: February 2023

The mechanisms of financing are key in reducing educational differences. Therefore, the provision of financing for systemic solutions and structures that facilitate the development of inclusive education is one of the key factors influencing the creation of this education model and its practical implementation. Among the organs responsible for organizing and implementing inclusive education in Poland are units of local government, which by implementing the local policy are obliged to take into account solutions that promote inclusion both in broadly understood social and educational activities. The objective of this study is to present research results pertaining to the role of local government units in shaping inclusive education and in promoting the idea of inclusion, as well as the preliminary identification of good practice in this field. The research was conducted using the focus interview method. The focus groups consisted of selected representatives the faculties/departments of education of municipal local government units which were diverse in terms of structure. It can be seen that the activities of local government units are important in terms of creating inclusive education and that they constitute the basis for the dissemination of good practice. A significant role is also assigned to the documents they create, such as municipal strategies and education financing plans.
Assign-to-Seat: Dynamic Capacity Control for Selling High-Speed Train Tickets
Authors: Zhu Feng , Liu Shaoxuan , Wang Rowan , Wang Zizhuo 
Published: February 2023

Problem definition: We consider a revenue management problem that arises from the selling of high-speed train tickets in China. Compared with traditional network revenue management problems, the new feature of our problem is the assign-to-seat restriction. That is, each request, if accepted, must be assigned instantly to a single seat throughout the whole journey, and later adjustment is not allowed. When making decisions, the seller needs to track not only the total seat capacity available, but also the status of each seat. Methodology/results: We build a modified network revenue management model for this problem. First, we study a static problem in which all requests are given. Although the problem is NP-hard in general, we identify conditions for solvability in polynomial time and propose efficient approximation algorithms for general cases. We then introduce a bid-price control policy based on a novel maximal sequence principle. This policy accommodates nonlinearity in bid prices and, as a result, yields a more accurate approximation of the value function than a traditional bid-price control policy does. Finally, we combine a dynamic view of the maximal sequence with the static solution of a primal problem to propose a “re-solving a dynamic primal” policy that can achieve uniformly bounded revenue loss under mild assumptions. Numerical experiments using both synthetic and real data document the advantage of our proposed policies on resource-allocation efficiency. Managerial implications: The results of this study reveal connections between our problem and traditional network revenue management problems. Particularly, we demonstrate that by adaptively using our proposed methods, the impact of the assign-to-seat restriction becomes limited both in theory and practice. Funding: S. Liu’s research is partly supported by the National Natural Science Foundation of China (NSFC) [Grant NSFC-72072117]. Z. Wang’s research is partly supported by the NSFC [Grant NSFC-72150002]. Supplemental Material: The online appendix is available at https://doi.org/10.1287/msom.2023.1188 .
Planejando rotas de fuga: uma autoetnografia dos desafios da humanização do parto no ambiente hospitalar em Maceió – AL
Authors: Allebrandt Débora 
Published: February 2023

No Brasil estima-se que 98% dos nascimentos ocorrem em ambiente hospitalar. Embora o movimento de humanização do parto tenha ganhado terreno na assistência ao parto domiciliar, o cenário é distinto quando falamos do parto hospitalar, pois é justamente no ambiente hospitalar que são produzidas as alarmantes taxas de cesarianas (80% no setor privado e 35% no setor público) e altos índices de intervenção. Este artigo busca, a partir de uma reflexão autoetnográfica, situar o cenário de atendimento ao parto hospitalar em Maceió – AL. O planejamento do parto, do pré-natal, contato com obstetras, enfermeiras e doulas até seu desfecho serão aproximados com a construção de uma rota de fuga num cenário hostil. A autoetnografia desafia aspectos formais do modo como construímos nosso lugar de fala como pesquisadoras e permite explorar a partir de uma vivência pessoal a emoção e da catarse como parte intrínseca à pesquisa social. Não silenciar a violência é tomado aqui como uma ferramenta para pensar alguns dos desafios da adesão às boas práticas e elaboração de uma crítica transformadora da assistência ao parto.
Effects of Sources, Boundaries, and Heterogeneities on Photon Migration
Authors: Jacques Steven L. , Ostermeyer Martin R. , Wang Lihong , Hielscher Andreas H. 
Published: February 2023

This paper considers three issues regarding the suitability of diffusion theory for calculations of
photon density waves:
(1) Directed sources, such as a collimated beam,
(2) Boundaries (eg., an air/tissue interface), and
(3) Heterogeneities (eg., tumor or vessel).
Heterogeneities have optical properties of absorption (µa) and scattering (µs'
= µs(1-g)) in [cm-1] which differ from the surrounding background tissue
properties, and are treated by a method of superposition of virtual sources (the SVS Method).
Novel Experimental and Theoretical Results on the Pulse Poling Mechanism of Second Order Nonlinear Optical Polymers
Authors: Michelotti Francesco , Toussaere Eric , Zyss Joseph 
Published: February 2023

Electrode poling of a crosslinkable electrooptic polymer was investigated upon application of cw and pulsed electric fields. The measurements were carried out on Red Acid Magly polymer, which is a crosslinkable extension of the currently used Disperse-Red 1 MMA side chain polymer1. Thin solid films were produced by spin coating on ITO coated glass substrates and then cladded with two adjacent gold electrodes. The ITO and gold layers were used both as poling and modulating electrodes throughout the measurements. Poling was obtained contemporarly in both zones by applying a cw electric field (130 V/µm) between ITO and one first electrode and a square wave electric field

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between ITO and the second electrode. Temperature was high enough to initiate the crosslinking process (Tp=130°C) and the time sufficiently long to saturate it2.
High power low intensity noise single frequency light sources at 1064 nm
Authors: Zawischa I. , Knoke S. , Zellmer H. , Tünnermann A. , Welling H. , Brozek O. S. , Danzmann K. , Freitag I. 
Published: February 2023

High power low noise lasers are needed in high precision interferometric gravitational wave detection In the GEO-600 gravitational wave detector a relative intensity noise of less than 10-8/√Hz and a frequency stability better than 10-3/√Hz will be required.
On power levels up to 2 W diode pumped non-planar monolithic Nd: YAG ring lasers (NPRO) are well known for their superior noise properties and their high potential for active stabilisation and intensity noise reduction [1].
Brain-derived neurotrophic factor in diabetes mellitus: A systematic review and meta-analysis
Authors: Moosaie Fatemeh , Mohammadi Soheil , Saghazadeh Amene , Dehghani Firouzabadi Fatemeh , Rezaei Nima 
Published: February 2023

Background
Brain-derived neurotrophic factor (BDNF) is a neurotrophic factor expressed in several tissues, including the brain, gut, and pancreas. Activation of the BDNF/TrkB/CREB reduces hepatic gluconeogenesis, induces hepatic insulin signal transduction, and protects against pancreatic beta-cell loss in diabetes mellitus (DM). Several studies have investigated the possible association between BDNF and DM and its complications, but the results have been conflicting.

Aim
In the present study, we aimed at systematically reviewing the literature on the serum and plasma levels of BDNF in DM and its subgroups such as T2DM, DM patients with depression, and patients with retinopathy.

Methods
A comprehensive search was conducted in PubMed, Scopus, and Web of Science. We identified 28 eligible studies and calculated the standardized mean difference (SMD) of outcomes as an effect measure.

Results
The meta-analysis included 2734 patients with DM and 6004 controls. Serum BDNF levels were significantly lower in patients with DM vs. controls (SMD = -1.00, P<0.001). Plasma BDNF levels were not different in patients with DM compared with controls. When conducting subgroup analysis, serum BDNF levels were lower among patients with T2DM (SMD = -1.26, P<0.001), DM and depression (SMD = -1.69, P<0.001), and patients with diabetic retinopathy (DR) vs. controls (SMD = -1.03, P = 0.01).

Conclusions
Serum BDNF levels were lower in patients with DM, T2DM, DM with depression, and DM and DR than the controls. Our findings are in line with the hypothesis that decreased BDNF levels might impair glucose metabolism and contribute to the pathogenesis of DM and its complications.
Effect of guided Ahmed glaucoma valve implantation on corneal endothelial cells: A 2-year comparative study
Authors: Chey Ji Hyoung , Lee Chang Kyu 
Published: February 2023

Purpose
To compare the effects of guided and non-guided Ahmed glaucoma valve (AGV) implantation on the corneal endothelium.

Methods
Medical records of patients who underwent AGV implantation in the anterior chamber (AC) were reviewed retrospectively. The eyes were divided into two groups depending on the use of a guidance technique with spatula and a 4–0 nylon intraluminal stent. Specular microscopy was performed to measure corneal endothelial cell density (ECD) loss after surgery, and the rate of ECD change was calculated. Tube parameters were measured using anterior segment optical coherence tomography (AS-OCT).

Results
The ECD loss during 2 years of follow-up was significantly lower in the guided AGV implantation (gAGV) group than in the non-guided implantation (ngAGV) group, and the rate of ECD change was -0.62 ± 1.23 and -1.42 ± 1.57%/month in the gAGV and ngAGV groups, respectively (p = 0.003). The mean tube–cornea distance (TCD) and mean tube–cornea angle (TCA) were significantly greater in the gAGV group than in the ngAGV group. The frequency of tube repositioning within 2 years after surgery was 0% in the gAGV group and 12.66% in the ngAGV group (p = 0.005).

Conclusions
The use of a guidance technique can reduce corneal endothelial loss during the first 2 years after AGV implantation in the AC. The tube was positioned at a more distant and wider angle from the cornea in the eyes of the gAGV group, which may have contributed to the reduced need for tube repositioning to prevent corneal decompensation.
Clinical outcomes of patients with rheumatoid arthritis who underwent percutaneous coronary intervention: A Korean nationwide cohort study
Authors: Ha Sang Jin , Park Se-Jun , Lee Bora , Moon Hyesung , Kim Bo Young 
Published: February 2023

Objective
Rheumatoid arthritis (RA) increases the risk of cardiovascular disease. This study aimed to investigate the short-and long-term prognosis of patients with and without RA who underwent percutaneous coronary intervention (PCI).

Methods
The Korean National Health Insurance Service claims database was used to extract data on 236,134 patients (34,493 with RA and 201,641 without RA) who underwent PCI between 2008 and 2019. The primary outcome was major adverse cardiovascular events (MACE), including all-cause mortality, myocardial infarction, stroke, transient ischemic attack, or coronary revascularization with short-term (30-day) and long-term outcomes. The secondary outcomes were the individual components of MACE.

Results
During a 10-year follow-up, patients with RA showed a shorter median survival time from MACE than their counterparts (with RA: 4.29 years vs. without RA: 6.10 years). RA was significantly associated with an increased risk of MACEs in long-term outcomes (hazard ratio (HR) 1.07, 95% confidence intervals (CI) 1.06–1.09, p<0.001), but not with short-term outcomes (HR 1.02, 95% CI 0.99–1.06, p = 0.222). RA was an independent predictor of an increased risk of all the MACE components.

Conclusion
In patients who underwent PCI, RA did not increase the risk of short-term cardiovascular outcomes but increased the risk of long-term adverse outcomes.