bluuebunny/crossref_metadata_2025_split huggingface dataset:
Scapegoating international students for the rental crisis? Insights from large-scale evidence (2017–2024) in Australia
Authors: Mu Guanglun Michael , Soong Hannah 
Published: January 2025

Abstract
Traditional international student destinations in the West are grappling with the thorny issue of rental crisis. In this challenging context for all, international students are caught within the political whims that blame them for the crisis. In this paper, we draw on large-scale evidence from Australia — including data collected at 76 time points from 2017 to 2023 at the national level and 79 time points from 2017 to 2024 at the capital city level — to investigate the statistical relationship between international student numbers and rental costs for local residents, while accounting for vacancy rate and rental inflation. Our findings challenge the politicised connection between international student numbers and rental costs. This study, the first of its kind in Australia and among the most recent internationally, makes a significant contribution by providing an evidence-grounded rebuttal against scapegoating international students for the rental crisis. It also enriches the emerging literature on international student housing, which we frame as part of a broader problematic termed “international studentification”. We caution against politicising international students in Australia and beyond, inviting future research to explore alternative pathways to establish a more just policy environment that enacts social and housing equity.
Antithrombotic therapy and the risk of pocket hematoma after subcutaneous implantable cardioverter-defibrillator implantation
Authors: Pepplinkhuizen S. , Kors N. , de Veld J. A. , Dijkshoorn L. A. , Bijsterveld N. R. , de Weger A. , Smeding L. , Wilde A. A. M. , Olde Nordkamp L. R. A. , Knops R. E. 
Published: January 2025

Abstract

Background
Little data exists regarding the optimal antithrombotic strategy during S-ICD implantation to prevent pocket hematomas. This study explores the association between perioperative antithrombotic management and the occurrence of pocket hematoma following S-ICD implantation.

Methods
All patients who underwent de novo S-ICD implantation between February 2009 and January 2023 at Amsterdam UMC were included. Data was collected retrospectively from electronic patient records. Clinically significant pocket hematomas were defined as an accumulation of blood at the pocket site within 30 days after implantation.

Results
A total of 347 patients were included of which 224 (64.6%) patients used antithrombotic therapy pre-implantation. The median age at implantation was 50 years (IQR 36–61 years), 33.4% of the patients were female, and the majority of implants were intermuscular (90.2%). A total of 18 patients (5.2%) developed a clinically significant pocket hematoma. There were significantly more pocket hematomas in patients with continued vitamin K antagonists (VKA) compared to patients with interrupted VKA (27.3% (6/22) vs. 4.3% (2/47), respectively, p = 0.01), and continuation of VKA was an independent predictor for pocket hematoma formation in the VKA group (p = 0.04). Moreover, continuation of dual antiplatelet therapy (DAPT) with ticagrelor was associated with significantly more pocket hematomas post-implantation compared to continuation of DAPT with clopidogrel (4/12 vs. 1/28, respectively, p = 0.02).

Conclusion
Continuation of VKA during S-ICD implantation was associated with an increased risk of pocket hematoma formation compared to interruption of VKA. This supports the need for specific perioperative antithrombotic therapy guidelines for S-ICD implantations to reduce the risk of pocket hematomas.

Graphical Abstract
The Classification of Two Lines Mahavier Products
Authors: Gril Rogina Rene , Brian Will 
Published: January 2025

Abstract
For non-negative real numbers r and

$$\rho $$

ρ

, with

$$r< 1 < \rho $$

r
<
1
<
ρ

, let

$$L_{r,\rho }$$

L

r
,
ρ

be the union of two straight line segments in

$$[0,1]\times [0,1]$$

[
0
,
1
]
×
[
0
,
1
]

with slopes r and

$$\rho $$

ρ

, one from (0, 0) to (1, r) and the other from (0, 0) to

$$(\frac{1}{\rho },0)$$

(

1
ρ

,
0
)

. Recent work in Banič et al.
(2024) and Gril Rogina (J Dyn Control Syst. 2023;29:1525–45) gives a partial characterization of the forward Mahavier products of such closed relations. But this work in Banič et al.
(2024) and Gril Rogina (J Dyn Control Syst. 2023;29:1525–45) leaves open the problem of whether certain classes of these Mahavier products contain any pairwise homeomorphic continua. In this paper, we show that any two of the continua in the above mentioned classes are homeomorphic, thus completing the classification of these Mahavier products.
Generative Artificial Intelligence Use in Healthcare: Opportunities for Clinical Excellence and Administrative Efficiency
Authors: Bhuyan Soumitra S. , Sateesh Vidyoth , Mukul Naya , Galvankar Alay , Mahmood Asos , Nauman Muhammad , Rai Akash , Bordoloi Kahuwa , Basu Urmi , Samuel Jim 
Published: January 2025

Abstract
Generative Artificial Intelligence (Gen AI) has transformative potential in healthcare to enhance patient care, personalize treatment options, train healthcare professionals, and advance medical research. This paper examines various clinical and non-clinical applications of Gen AI. In clinical settings, Gen AI supports the creation of customized treatment plans, generation of synthetic data, analysis of medical images, nursing workflow management, risk prediction, pandemic preparedness, and population health management. By automating administrative tasks such as medical documentations, Gen AI has the potential to reduce clinician burnout, freeing more time for direct patient care. Furthermore, application of Gen AI may enhance surgical outcomes by providing real-time feedback and automation of certain tasks in operating rooms. The generation of synthetic data opens new avenues for model training for diseases and simulation, enhancing research capabilities and improving predictive accuracy. In non-clinical contexts, Gen AI improves medical education, public relations, revenue cycle management, healthcare marketing etc. Its capacity for continuous learning and adaptation enables it to drive ongoing improvements in clinical and operational efficiencies, making healthcare delivery more proactive, predictive, and precise.
Competitive signaling and cellular communications in myocardial infarction response
Authors: Nair Vishnu , Demitri Christian , Thankam Finosh G. 
Published: January 2025

Abstract
Cell communication and competition pathways are malleable to Myocardial Infarction (MI). Key signals, transcriptive regulators, and metabolites associated with apoptotic responses such as Myc, mTOR, and p53 are important players in the myocardium. The individual state of cardiomyocytes, fibroblasts, and macrophages in the heart tissue are adaptable in times of stress. The overlapping communication pathways of Wnt/β-catenin, Notch, and c-Kit exhibit the involvement of important factors in cell competition in the myocardium. Depending on the effects of these pathways on genetic expression and signal amplification, the proliferative capacities of the previously stated cells that make up the myocardium, amplify or diminish. This creates a distinct classification of “fit” and “unfit” cells. Beyond straightforward traits, the intricate metabolite interactions between neighboring cells unveil a complex battle. Strategic manipulation of these pathways holds translational promise for rapid cardiac recovery post-trauma.
Applying an Equity Lens to Evidence-Based Preventive Interventions: a Systematic Review of Subgroup Findings from Experimental Evaluations
Authors: Buckley Pamela R. , Gust Charleen J. , Coffin Sarah Gonzalez , Aikawa Sheba M. , Steeger Christine M. , Pampel Fred C. 
Published: January 2025

Abstract
Evidence reveals that minoritized groups face disparities, underscoring the need for interventions to address behavioral health inequities. This review examined which minoritized populations are represented in evidence-based preventive interventions (EBPIs) and whether they equitably benefit from these programs. Using the Blueprints for Healthy Youth Development online clearinghouse, we synthesized findings from 240 high-quality experimental evaluations of EBPIs conducted in the U.S. between 2010 and 2023 and performed a descriptive analysis based on consensus coding to assess (1) the prevalence of culturally tailored EBPIs; (2) how frequently tests for subgroup effects were conducted; and (3) whether subgroup tests indicated differential benefits for minoritized groups. We found few culturally tailored interventions (31%), with 4% evaluating EBPIs developed for African American or Black populations and 1% for Hispanic or Latino youth. Additionally, only 25% and 15% tested for subgroup effects by race and ethnicity, respectively. For other subgroups, few (28%) evaluations included effects by economic disadvantage while 47% examined outcomes by binary gender categories. Essentially no reports tested for subgroup effects by sexual identity, location, or nativity status. Encouraging findings were that EBPIs more often benefited racial and ethnic minoritized groups, and there was an upward trend in reporting subgroup tests across time. EBPIs should test for subgroup effects to answer the questions of “what works for whom?” and “in which settings?” and to better understand the generalizability of findings. Investments are needed in culturally grounded programs developed for historically marginalized populations and trials of EBPIs that investigate mitigating health disparities.
A Model for Understanding and Expanding the Scope of Critical Thinking
Authors: Normile Ian H. 
Published: January 2025

Abstract
In this article I draw on existing theory in a project of synthesis and integration to develop a terminological, conceptual, and graphic model for understanding the scope of critical thinking. I begin by showing why the idea of critical scope matters. I then develop a model that maps the scope of critical thinking across individual, sociocultural, and existential domains, in conjunction with the ontological, epistemological, emotional, and political dimensions. Building on this, I outline the relationships between contexts, critical frameworks, and metacritique as essential to understanding the scope of critical thinking. The model also includes a means for organising the attributes (character traits) of critical thinkers. This project provides resources to encourage and guide critical thinking at a more expansive scope in education, society, and daily life by helping people to understand the contours and potential confines of criticality. This has profound implications for education and society, helping to improve the rigour, reach, and diversity of critical thinking. This model is far from complete, and designed to invite ongoing engagement, including critique. It is intended as a rubric to prompt and inspire, not as a device to ‘measure’ or ‘assess’ critical thinking. Educationally, the intention is to provide resources for understanding, negotiating, and facilitating critical thinking at an expansive scope.
Synthetic biology: supporting an anti-reductionist view of life
Authors: Rijssenbeek Julia 
Published: January 2025

Abstract
The life sciences have evoked long-standing philosophical debates on a system view of life versus a reductionist view that reduces the complexity of life-forms to parts-based entities that can be described purely mechanistically. This paper examines how current scientific advances in the life sciences can contribute to an anti-reductionist concept of life. It does so by looking at synthetic biology, a discipline within the life sciences that has an ambiguous relationship to this debate. While the field’s engineering approach to life could be considered a manifestation of a reductionist view of life, it also builds on a more holistic, systems view of life. This paper analyses recent scientific practices taking place within synthetic biology that seem to challenge the reductionist view of life. After analyzing the main anti-reductionist philosophical accounts of life, I ask how synthetic biology practices can support these accounts of life by considering living systems as processual, collaborative, and cognitive, and life versus nonlife on a more gradual scale. This empirically informed paper contributes to the literature by drawing observations about the concept of life by connecting the following: the reductionist view in the life sciences, the different anti-reductionist metaphysical stances in the philosophy of biology, and the emerging practices in synthetic biology. The paper concludes that synthetic biology can support anti-reductionist views of life in the philosophy of biology.
Dietary flaxseed: Cardiometabolic benefits and its role in promoting healthy aging
Authors: Kunutsor Setor K. , Jassal Davinder S. , Ravandi Amir , Lehoczki Andrea 
Published: January 2025

Abstract
Flaxseed, a rich source of omega-3 polyunsaturated fatty acid alpha-linolenic acid (ALA), lignans, and soluble fiber, has attracted attention for its potential to improve multiple cardiometabolic risk factors. While its benefits are well-recognized, comprehensive evaluations of its direct impact on clinical outcomes, such as the prevention or progression of cardiometabolic diseases, remain limited. Additionally, its potential to support healthy aging and longevity through fundamental biological mechanisms has not been fully elucidated. This review synthesizes existing research on flaxseed supplementation, highlighting its effects on cardiometabolic risk factors and outcomes, the underlying biological mechanisms, and its broader implications for health promotion and aging. Findings demonstrate that flaxseed supplementation significantly improves several cardiometabolic risk factors, including body weight, body mass index, lipid levels, blood pressure, glycemic measures, markers of inflammation (e.g., C-reactive protein and interleukin-6), oxidative stress, and liver enzymes. Blood pressure reductions range from approximately 2 to 15 mmHg for systolic blood pressure and 1 to 7 mmHg for diastolic blood pressure, with the magnitude influenced by dose, duration, and baseline risk profiles. While direct evidence linking flaxseed to the prevention of hypertension, metabolic syndrome, metabolic dysfunction-associated steatotic liver disease, type 2 diabetes, chronic kidney disease, and cardiovascular disease is limited, its bioactive components—ALA, lignans, and fiber—are strongly associated with reduced risks of these conditions. The benefits of flaxseed are mediated through multiple pathways, including anti-inflammatory and antioxidant effects, improved lipid levels, improved glucose metabolism and insulin sensitivity, modulation of gut microbiota, and enhanced vascular health. Beyond cardiometabolic outcomes, flaxseed may influence key biological processes relevant to aging, underscoring its potential to promote healthy aging and longevity. Optimal cardiometabolic benefits appear to be achieved with ground whole flaxseed at doses of ≥ 30 g/day for at least 12 weeks, particularly among individuals at high cardiometabolic risk. Future research should focus on elucidating flaxseed’s mechanisms of action, clarifying its role in disease prevention, and refining dietary recommendations to harness its potential for cardiometabolic health and aging interventions.
Learning to thrive through autonomy: a thematic analysis of the role of recalled parental autonomy in the transition to motherhood
Authors: Lee Kang Qi , Barlas Joanna , Gill Davinder 
Published: January 2025

Abstract
Becoming a mother requires the continual redefinition of current self-identity. This can be challenging for women who struggle being autonomous due to unfulfilled core emotional needs from early interactions with primary caregivers. Existing literature on the impact of early experiences on motherhood is largely quantitative and focuses on adverse childhood experiences and broad parenting constructs. Informed by the findings of our quantitative study (Leong et al., 2024), this secondary predominately qualitative study explored primiparous mothers’ perceptions of both adverse and positive experiences of parental autonomy, and how they draw upon those experiences in early motherhood. The sample comprised 15 first-time mothers in their first-year post-birth, aged 18–36, recruited in Singapore from a large mixed-method study which examined the impact of early experiences of being parented on postnatal mental health. Referencing specific interactions on the Positive Parenting Schema Inventory (PPSI; Louis et al., 2020a) and the Young Parenting Inventory Revised (YPI-R2; Louis et al., 2018), semi-structured interviews were conducted with the mothers on their perceptions of parental autonomy and how those experiences impacted their parenting style, sense of competence and postnatal mental health. Interview transcripts were analysed drawing upon guidelines and principles of reflexive thematic analysis. Three broad themes were generated; (i) making sense of autonomy; (ii) learning to thrive through autonomy; and (iii) striving for balance through autonomy. The findings highlight the instrumental role of parental autonomy and culture in the transition to motherhood and inform the design and implementation of postnatal mental health services, parenting programmes and future research.
Anticancer effect of the antirheumatic drug leflunomide on oral squamous cell carcinoma by the inhibition of tumor angiogenesis
Authors: Niwata Chieko , Nakagawa Takayuki , Naruse Takako , Sakuma Miyuki , Yamakado Nao , Akagi Misaki , Ono Shigehiro , Tobiume Kei , Gao Jing , Jimi Eijiro , Ohta Kouji , Aikawa Tomonao 
Published: January 2025

Abstract

Objectives
Leflunomide (LEF) is a conventional synthetic disease-modifying antirheumatic drug and suppresses T-cell proliferation and activity by inhibiting pyrimidine synthesis using dihydroorotase dehydrogenase (DHODH); however, several studies have demonstrated that LEF possesses anticancer and antiangiogenic effects in some malignant tumors. Therefore, we investigated the anticancer and antiangiogenic effects of LEF on oral squamous cell carcinoma (OSCC).

Methods
To evaluate the inhibitory effect of LEF on OSCC, cell proliferation and wound-healing assays using human OSCC cell lines were performed. The DHODH inhibitory effect of LEF was evaluated by Western blot. To assess the suppression of pyrimidine biosynthesis induced by LEF on OSCC, cell proliferation assays with or without uridine supplementation were performed. The antiangiogenic effect of LEF was evaluated by in vitro tube formation assay using immortalized human umbilical vein endothelial cells, which were electroporatically transfected with hTERT. The tumor-suppressive effect of LEF in vivo was examined in both immunodeficient and syngeneic mice by implanting mouse OSCC cells. Tumor vascularization was evaluated by immunohistochemistry of the tumor extracted from syngeneic mice.

Results
LEF dose-dependently inhibited OSCC proliferation and migration. LEF significantly inhibited DHODH expression, and uridine supplementation rescued the inhibitory effect of LEF. LEF dose-dependently suppressed endothelial tube formation. In the animal study, LEF significantly suppressed tumor growth in both immunodeficient and syngeneic mice. Histologically, LEF decreased DHODH expression and tumor vascularization.

Conclusion
LEF is a potent anticancer agent with antiangiogenic effects on OSCC and might be clinically applicable to OSCC by drug repositioning.
Propensity-score matched outcomes of minimally invasive and open pelvic exenteration in locally advanced rectal cancer
Authors: Emile Sameh Hany , Horesh Nir , Garoufalia Zoe , Gefen Rachel , Dourado Justin , Salama Ebram , Wexner Steven D. 
Published: January 2025

Abstract
Pelvic exenteration (PE) entails an en bloc resection of locally advanced primary or recurrent rectal cancer. This study aimed to assess the short-term and survival outcomes of minimally invasive (MI)- and open PE. A retrospective cohort analysis of patients with stage III rectal adenocarcinoma treated with PE from the National Cancer Database (2010–2019) was conducted. Open and MI-PE were matched for baseline and treatment characteristics using 2:1 propensity score matching. Primary outcomes were 30- and 90-day mortality; secondary outcomes included 30-day readmission, hospital stay, surgical margins, lymph node yield, and overall survival (OS). PE was performed in 1010 (1.9%) of 52,242 patients; 705 (69.8%) were open and 304 were (30.2%) MI procedures. After matching, 169 patients in the MI-PE group were matched to 338 patients in the open PE group. The matched cohort included 507 patients (54.2% female). Hospital stay was shorter after MI compared to open PE (median: 6 vs. 8 days, p < 0.001). MI and open PE had similar odds of 30- (OR: 0.33, p = 0.306) and 90-day mortality (OR: 0.29, p = 0.113), and comparable rates of positive surgical margins (12.7% vs. 15%, p = 0.586) and suboptimal lymph node yield (19% vs. 26%, p = 0.096). MI-PE had a similar OS to open surgery (82.5 vs. 77.5 months, p = 0.281). Robotic-assisted PE was associated with significantly lower odds of conversion to open surgery (OR: 0.15, p = 0.003) and shorter hospital stay (median: 5 vs. 7 days, p = 0.026) than laparoscopic PE. MI-PE provided similar pathologic and survival outcomes to open PE with comparable short-term mortality rates and significantly shorter hospital stays.
Theoretical and Experimental Investigation of the Use of a Roving Mass with Rotary Inertia for Crack Detection in Beam-Like Structures
Authors: Sun X. , Ilanko S. , Mochida Y. , Tighe R. C. , Mace B. R. 
Published: January 2025

Abstract

Purpose
Natural frequency is a global dynamic parameter that normally contains limited spatial information on a crack in a structure. However, recently a theoretical concept that a roving mass with rotary inertia causes sudden frequency shifts when located near the crack location has been proposed as a method of locating cracks, although experimental verification is still lacking. This study fills this gap in knowledge, by investigating the measurability of the frequency shift as a roving body passes a crack.

Methods
Natural frequencies were measured through impact hammer tests and compared with frequencies calculated using the dynamic stiffness method and finite element method.

Results
The results show that the natural frequency shift could be clearly measured for a beam featuring a medium sized crack. For smaller cracks, while numerical results show that the current method would still enable the identification of their locations as frequency shifts are in the measurable range, the number of locations at which the measurement needs to be taken can be very large.

Conclusions
This study provides insights into the practical feasibility of the roving mass technique for crack detection.