bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of early acute‐phase rehabilitation initiation on outcomes among patients aged ≥90 years with acute heart failure
Authors: Ueno Kensuke , Kaneko Hidehiro , Kamiya Kentaro , Okada Akira , Itoh Hidetaka , Konishi Masaaki , Sugimoto Tadafumi , Suzuki Yuta , Matsuoka Satoshi , Fujiu Katsuhito , Michihata Nobuaki , Jo Taisuke , Takeda Norifumi , Morita Hiroyuki , Ako Junya , Node Koichi , Yasunaga Hideo , Komuro Issei 
Published: March 2023

AbstractBackgroundData on the potential benefit of acute‐phase rehabilitation initiation in very old (aged ≥90) patients with acute heart failure (AHF) have been scarce.MethodsWe retrospectively analyzed data from the Diagnosis Procedure Combination database, which is a nationwide inpatient database. This study included patients hospitalized for heart failure (HF) from January 2010 to March 2018, those aged ≥90 years, who had a length of stay of ≥3 days, New York Heart Association (NYHA) class of ≥II, and had not undergone major procedures under general anesthesia. Propensity score matching and generalized linear models were used to compare in‐hospital mortality, length of stay, 30‐day readmission rate due to HF, all‐cause 30‐day readmission, and improvement in activities of daily living (ADL) between patients with and without an acute‐phase rehabilitation initiation, which is defined as the rehabilitation initiation within 2 days after hospital admission.ResultsAcute‐phase rehabilitation was initiated in 8588 of 41,896 eligible patients. Propensity score matching created 8587 pairs. Patients with acute‐phase rehabilitation initiation have lower in‐hospital mortality (9.0% vs. 11.2%, p < 0.001). Acute‐phase rehabilitation initiation was associated with lower in‐hospital mortality (odds ratio, 0.778; 95% confidence interval, 0.704–0.860). Patients with acute‐phase rehabilitation initiation have a shorter median length of stay (17 days vs. 18 days, p < 0.001), lower 30‐day readmission rate due to HF (5.5% vs. 6.4%, p = 0.011) and all‐cause 30‐day readmission (10.2% vs. 11.2%, p = 0.036), and better ADL improvement (49.7% vs. 46.9%, p < 0.001). Subgroup analysis revealed consistent results (sex, body mass index, NYHA class, and Barthel Index).ConclusionsThe acute‐phase rehabilitation initiation was associated with improved short‐term clinical outcomes in patients aged ≥90 years with AHF.
Effects of Cultural Intelligence on Perceived Stress Among the Japanese Overseas Workers
Authors: Tabuse Midori , Otsuka Yasumasa 
Published: March 2023

AbstractWe evaluated the effects of cultural intelligence (CQ) on perceived stress and explored the factors associated with CQ. We constructed a model that included the antecedents that may affect the CQ based on hypotheses derived from a preliminary feasibility study. The main study comprised an Internet survey of Japanese workers who were currently working or had previously worked overseas (n = 296). The Expanded Cultural Intelligence Scale (E‐CQS) was used to assess the CQ and the Perceived Stress Scale was used to assess the cognitive appraisal of stressors. The path analysis results showed that “Self‐efficacy to adjust” in CQ was influenced by all explored antecedents and negatively related to perceived stress. This suggests that facilitating the antecedents of CQ and developing “Self‐efficacy to adjust” may ameliorate perceived stress in overseas Japanese workers.
Introgressive hybridization in the west Pacific pen shells (genus Atrina): Restricted interspecies gene flow within the genome
Authors: Sekino Masashi , Hashimoto Kazumasa , Nakamichi Reiichiro , Yamamoto Masayuki , Fujinami Yuichiro , Sasaki Takenori 
Published: March 2023

AbstractA compelling interest in marine biology is to elucidate how species boundaries between sympatric free‐spawning marine invertebrates such as bivalve molluscs are maintained in the face of potential hybridization. Hybrid zones provide the natural resources for us to study the underlying genetic mechanisms of reproductive isolation between hybridizing species. Against this backdrop, we examined the occurrence of introgressive hybridization (introgression) between two bivalves distributed in the western Pacific margin, Atrina japonica and Atrina lischkeana, based on single‐nucleotide polymorphisms (SNPs) derived from restriction site‐associated DNA sequencing. Using 1066 ancestry‐informative SNP sites, we also investigated the extent of introgression within the genome to search for SNP sites with reduced interspecies gene flow. A series of our individual‐level clustering analyses including the principal component analysis, Bayesian model‐based clustering, and triangle plotting based on ancestry–heterozygosity relationships for an admixed population sample from the Seto Inland Sea (Japan) consistently suggested the presence of specimens with varying degrees of genomic admixture, thereby implying that the two species are not completely isolated. The Bayesian genomic cline analysis identified 10 SNP sites with reduced introgression, each of which was located within a genic region or an intergenic region physically close to a functional gene. No, or very few, heterozygotes were observed at these sites in the hybrid zone, suggesting that selection acts against heterozygotes. Accordingly, we raised the possibility that the SNP sites are within genomic regions that are incompatible between the two species. Our finding of restricted interspecies gene flow at certain genomic regions gives new insight into the maintenance of species boundaries in hybridizing broadcast‐spawning molluscs.
Introduction to the symposium “What makes a philosopher (good or bad)? Philosophical virtues and vices: Past and present”
Authors: Verburgt Lukas M. 
Published: March 2023

AbstractThe main ambition of the eight articles in this collection is to bring together two currently distinct bodies of literature—on scholarly virtues and vices in the sciences and the humanities, and on epistemic virtues and vices—and to jointly connect them to recent work in (revisionary) historiography of philosophy. This introduction briefly reflects on this ambition, providing background and context, and offers a short overview of the eight articles.
Negative regulation of biofilm development by the CUG‐Ser1 clade‐specific histone H3 variant is dependent on the canonical histone chaperone CAF‐1 complex in Candida albicans
Authors: Singha Rima , Aggarwal Rashi , Sanyal Kaustuv 
Published: March 2023

AbstractThe CUG‐Ser1 clade‐specific histone H3 variant (H3VCTG) has been reported to be a negative regulator of planktonic to biofilm growth transition in Candida albicans. The preferential binding of H3VCTG at the biofilm gene promoters makes chromatin repressive for the biofilm mode of growth. The two evolutionarily conserved chaperone complexes involved in incorporating histone H3 are CAF‐1 and HIRA. In this study, we sought to identify the chaperone complex(es) involved in loading H3VCTG. We demonstrate that C. albicans cells lacking either Cac1 or Cac2 subunit of the CAF‐1 chaperone complex, exhibit a hyper‐filamentation phenotype on solid surfaces and form more robust biofilms than wild‐type cells, thereby mimicking the phenotype of the H3VCTG null mutant. None of the subunits of the HIRA chaperone complex shows any significant difference in biofilm growth as compared to the wild type. The occupancy of H3VCTG is found to be significantly reduced at the promoters of biofilm genes in the absence of CAF‐1 subunits. Hence, we provide evidence that CAF‐1, a chaperone known to load canonical histone H3 in mammalian cells, is involved in chaperoning of variant histone H3VCTG at the biofilm gene promoters in C. albicans. Our findings also illustrate the acquisition of an unconventional role of the CAF‐1 chaperone complex in morphogenesis in C. albicans.
Effect of vagus nerve stimulation in patient with prolonged postictal encephalopathy
Authors: Kang Mi‐Ri , Ji Ki‐Hwan 
Published: March 2023

AbstractVagus nerve stimulation (VNS) has rarely been used in adult patients with status epilepticus (SE). Although evidence for VNS's effect on consciousness is largely lacking, VNS implantation may be considered an option in a prolonged unconscious state after SE. Here, we present the case of a woman with prolonged SE whose consciousness incompletely recovered after seizure cessation with conventional therapy but fully recovered after activation of VNS.
Contrasting effector profiles between bacterial colonisers of kiwifruit reveal redundant roles converging on PTI‐suppression and RIN4
Authors: Jayaraman Jay , Yoon Minsoo , Hemara Lauren M. , Bohne Deborah , Tahir Jibran , Chen Ronan K. Y. , Brendolise Cyril , Rikkerink Erik H. A. , Templeton Matthew D. 
Published: March 2023

Summary

Testing effector knockout strains of the Pseudomonas syringae pv. actinidiae biovar 3 (Psa3) for reduced in planta growth in their native kiwifruit host revealed a number of nonredundant effectors that contribute to Psa3 virulence. Conversely, complementation in the weak kiwifruit pathogen P. syringae pv. actinidifoliorum (Pfm) for increased growth identified redundant Psa3 effectors.

Psa3 effectors hopAZ1a and HopS2b and the entire exchangeable effector locus (ΔEEL; 10 effectors) were significant contributors to bacterial colonisation of the host and were additive in their effects on virulence. Four of the EEL effectors (HopD1a, AvrB2b, HopAW1a and HopD2a) redundantly contribute to virulence through suppression of pattern‐triggered immunity (PTI).

Important Psa3 effectors include several redundantly required effectors early in the infection process (HopZ5a, HopH1a, AvrPto1b, AvrRpm1a and HopF1e). These largely target the plant immunity hub, RIN4.

This comprehensive effector profiling revealed that Psa3 carries robust effector redundancy for a large portion of its effectors, covering a few functions critical to disease.
Extremally rare cause of AV block during typical atrial flutter ablation not related to conduction tissue injury
Authors: Choudhary Khushal , Santiago Leonell Freytes , Reade Daniel , Tojcic Dejan , Jallad Ahmad , Budzikowski Adam S. 
Published: March 2023

AbstractBackground51‐year‐old female with extensive prior atrial surgery involving myxoma resection and patch septum repair and prior typical atrial flutter as well as peripatch reentry underwent redo radiofrequency ablation of typical atrial flutter.MethodsAfter high density mapping was performed, and gap in the prior typical flutter line was ablated.ResultDuring the ablation transient atrioventricular (AV) block was noted. Subsequent remapping of the right atrium revealed that there was a narrow strip of tissue between the cavo‐tricuspid isthmus (CTI) and the coronary sinus (CS) os on which activation of the AV node was now depending. From all other directions, the AV node was surrounded by scar tissue.ConclusionsThe most likely explanation for the transient AV block during the ablation procedure is that there was reversible injury to the tissue strip between the CTI and the CS os, which is critical for the activation of the AV node.
Health as a movement between suffering of life and meaning in life for men who have experienced transitions in life
Authors: Koskinen Camilla , Nyholm Linda , Thorkildsen Kari Marie , Haga Britt Marit , Wallgren Gry Ciekals , Kaldestad Kari 
Published: March 2023

AbstractBackground and AimPrevious studies show that life transitions can have negative effects on men's lives and lead to health problems and meaninglessness in life. This study aims to deepen the understanding of men's health by exploring the movement between suffering of life and meaning in life when experienced life transitions.Theoretical FrameworkThe study is anchored in Eriksson's caritative caring theory. Core concepts are health and the movement between suffering of life and meaning in life.Methodology and MethodsThe methodology is hermeneutical, and the study has a qualitative research design. Fifteen men from Norway participated in in‐depth interviews in 2021. The interviews were analysed using reflexive thematic analysis.ResultsFour themes emerged in relation to the suffering of life; enduring separation from community, shame at being useless as a human being, grief over what has been lost in life, and being powerless and vulnerable in the face of a hopeless struggle. Three themes emerged in relation to meaning in life; realising what is most important in one's life gives strength, decision to live one's life brings joy in life and a positive attitude towards life gives freedom and awakens a new spark for life.ConclusionSuffering of life emerges as a separation from relationships and society and as a perceived uselessness as a human being losing faith, control and feeling like a burden erodes dignity and trigger feelings of shame, guilt and degradation. Suffering of life manifests as loss of drive and spark for life. Life has meaning through finding the good in oneself, coming to know and believe in oneself and seeing new possibilities which bring about a spark for life, gratitude, dignity and freedom. Health exists in the movement between suffering of life and meaning in life, in pausing, recognising vulnerability, prioritising and reorienting oneself.
Singapore's Imminent Expiration of Land Leases: From Growth and Equality to Discontent and Inequality?
Authors: Purves Andrew 
Published: March 2023

AbstractHaila described Singapore as a laboratory for a social scientist given the multiple ways land is used, managed or treated as a source of public revenue. Phang explains how housing has given the bottom 50 per cent of households, wealth equating to the level advocated in Piketty's ‘ideal society’. As fixed‐term leases expire, people who own apartments on public land will see their values fall to zero. Inequality will return, challenging the otherwise stable polity. Using both qualitative and quantitative methods, this paper explores how and why this unique land regime was created, and expose how theoretically inconsistent policies and their ad hoc, pragmatic application has created several rent leakages to a minority of the population who continue to hold freehold land. It offers some alternative strategies better informed by land rent theory, that might be adopted to preserve the benefits enjoyed for now.
Decreased corneal subbasal nerve fiber length and density in diabetic dogs with cataracts using in vivo confocal microscopy
Authors: Chan Kore , Badanes Zachary , Ledbetter Eric C. 
Published: March 2023

AbstractObjectiveTo determine whether there is a difference in corneal sensitivity and corneal subbasal nerve plexus (CSNP) morphology in cataractous dogs with diabetes mellitus (DM) versus without DM.Animals studiedTwenty six domestic dogs with cataracts of various breeds presented for phacoemulsification, 13 with DM and 13 without DM.ProcedureThe inclusion criteria for the study were dogs with bilateral cataracts and no clinical evidence of corneal disease. The diabetic group had documented hyperglycemia and was currently treated with insulin. The non‐diabetic group had no evidence of DM on examination and bloodwork. Complete ophthalmic examination, corneal esthesiometry, and in vivo confocal microscopy of the CSNP was performed for both eyes of each dog. The CSNP was evaluated using a semi‐automated program and statistically analyzed.ResultsThe mean (±SD) CSNP fiber length was significantly decreased in diabetic (3.8 ± 3.0 mm/mm2) versus non‐diabetic (6.7 ± 1.9 mm/mm2) dogs. Likewise, the mean (±SD) fiber density was significantly decreased in diabetic (8.3 ± 3.1 fibers/mm2) versus non‐diabetic (15.5 ± 4.9 fibers/mm2) dogs. The corneal touch threshold was significantly reduced in diabetic (2.1 ± 0.8 cm) versus non‐diabetic (2.8 ± 0.4 cm) dogs. There was a non‐significant trend towards subclinical keratitis in diabetic (9/13) versus non‐diabetic (4/13) dogs.ConclusionsMorphological and functional abnormalities of the CSNP were present in dogs with DM, including decreased fiber length, fiber density, and corneal sensitivity. These findings are consistent with diabetic neuropathy and could contribute to clinically significant corneal complications after cataract surgery.
Investigating intermediate hosts of Echinococcus multilocularis throughout Turkey: Focus on voles
Authors: Gürler Ali Tümay , Demirtaş Sadık , Bölükbaş Cenk Soner , Gençay Elif Burcu , Barılı Öykü , Karaca Efe , Akçay Aytaç , Açıcı Mustafa , Umur Şinasi , Deplazes Peter 
Published: March 2023

AbstractAlveolar echinococcosis (AE), caused by Echinococcus multilocularis, is one of the most important zoonotic diseases. The parasite has a heterogeneous life cycle; more than 40 small mammal species have been determined to be potential intermediate hosts worldwide. Turkey is one of the highest endemic countries for AE, but only limited information is available concerning the transmission biology of E. multilocularis. The study aimed to provide data on potential intermediate host species (focus on genus Microtus) across Turkey involved in E. multilocularis transmission to foxes, which is a risk for public health. Trapping sites have been specially selected considering field voles' habitats and ecological requirements. In total, 843 rodents were collected from 141 locations. The metacestodes and lesions of AE were identified as macroscopy and microscopy and confirmed by PCR and DNA sequencing. Seventeen (2.0%) small mammals from 13 (9.2%) locations were found infected with E. multilocularis. Infected individuals were identified as Microtus irani, Microtus mystacinus, Microtus hartingi, Microtus guentheri, Cricetulus migratorius and Mus macedonicus. M. hartingi and M. macedonicus are documented for the first time as intermediate hosts of E. multilocularis. In conclusion, 15 of 17 infected small mammals were found in the Microtus genus. Therefore, the genus Microtus, which inhabits fields near villages and is potential prey for foxes, could be considered an important intermediate host for E. multilocularis across Turkey.
Non-occupational physical activity and risk of cardiovascular disease, cancer and mortality outcomes: a dose–response meta-analysis of large prospective studies
Authors: Garcia Leandro , Pearce Matthew , Abbas Ali , Mok Alexander , Strain Tessa , Ali Sara , Crippa Alessio , Dempsey Paddy C , Golubic Rajna , Kelly Paul , Laird Yvonne , McNamara Eoin , Moore Samuel , de Sa Thiago Herick , Smith Andrea D , Wijndaele Katrien , Woodcock James , Brage Soren 
Published: March 2023

ObjectiveTo estimate the dose–response associations between non-occupational physical activity and several chronic disease and mortality outcomes in the general adult population.DesignSystematic review and cohort-level dose-response meta-analysis.Data sourcesPubMed, Scopus, Web of Science and reference lists of published studies.Eligibility criteriaProspective cohort studies with (1) general population samples >10 000 adults, (2) ≥3 physical activity categories, and (3) risk measures and CIs for all-cause mortality or incident total cardiovascular disease, coronary heart disease, stroke, heart failure, total cancer and site-specific cancers (head and neck, myeloid leukaemia, myeloma, gastric cardia, lung, liver, endometrium, colon, breast, bladder, rectum, oesophagus, prostate, kidney).Results196 articles were included, covering 94 cohorts with >30 million participants. The evidence base was largest for all-cause mortality (50 separate results; 163 415 543 person-years, 811 616 events), and incidence of cardiovascular disease (37 results; 28 884 209 person-years, 74 757 events) and cancer (31 results; 35 500 867 person-years, 185 870 events). In general, higher activity levels were associated with lower risk of all outcomes. Differences in risk were greater between 0 and 8.75 marginal metabolic equivalent of task-hours per week (mMET-hours/week) (equivalent to the recommended 150 min/week of moderate-to-vigorous aerobic physical activity), with smaller marginal differences in risk above this level to 17.5 mMET-hours/week, beyond which additional differences were small and uncertain. Associations were stronger for all-cause (relative risk (RR) at 8.75 mMET-hours/week: 0.69, 95% CI 0.65 to 0.73) and cardiovascular disease (RR at 8.75 mMET-hours/week: 0.71, 95% CI 0.66 to 0.77) mortality than for cancer mortality (RR at 8.75 mMET-hours/week: 0.85, 95% CI 0.81 to 0.89). If all insufficiently active individuals had achieved 8.75 mMET-hours/week, 15.7% (95% CI 13.1 to 18.2) of all premature deaths would have been averted.ConclusionsInverse non-linear dose–response associations suggest substantial protection against a range of chronic disease outcomes from small increases in non-occupational physical activity in inactive adults.PROSPERO registration numberCRD42018095481.
Effects of the acceleration on holographic complexity
Authors: Nagasaki Koichi 
Published: March 2023

In this work, we consider a special kind of space–time called AdS accelerating black holes. This is a kind of black holes which have a stringlike singularity along polar axis attached to the black hole and it accelerates the black hole. In these kind of space–times, the growth of Einstein–Hilbert action is independent of the acceleration as found in S. Chen and Y. Pei, Int. J. Theor. Phys. 60, 917 (2021). By using a string as a probe, we found the effect of the acceleration is captured by the string probe [K. Nagasaki, arXiv:2108.05429 [hep-th]]. Here in this work, we consider the case of rotating black holes. By the probe string, we clearly describe the effect of the acceleration and its relation to the rotation of the black holes.
Global dominator coloring of unicyclic graphs
Authors: Rajeswari M. , Anitha A. , Sahul Hamid I. 
Published: March 2023

Let [Formula: see text]. A vertex [Formula: see text] is a dominator of [Formula: see text] if [Formula: see text] dominates every vertex in [Formula: see text] and [Formula: see text] is said to be an anti-dominator of [Formula: see text] if [Formula: see text] dominates none of the vertices of [Formula: see text]. Let [Formula: see text] be a coloring of [Formula: see text] and let [Formula: see text]. A color class [Formula: see text] is called a dom-color class or an anti-dom-color class of the vertex [Formula: see text] according as [Formula: see text] is a dominator of [Formula: see text] or an anti-dominator of [Formula: see text]. The coloring [Formula: see text] is called a global dominator coloring of [Formula: see text] if every vertex of [Formula: see text] has a dom-color class and an anti-dom-color class in [Formula: see text]. The minimum number of colors required for a global dominator coloring of [Formula: see text] is called the global dominator chromatic number and is denoted by [Formula: see text]. This parameter was introduced in [I. S. Hamid and M. Rajeswari, Global dominator coloring of graphs, Discuss. Math. Graph Theory 39 (2019) 325–339]. This paper further extends the study by obtaining the value of [Formula: see text] for unicyclic graphs.