bluuebunny/crossref_metadata_2025_split huggingface dataset:
A framework for the continuous monitoring of person-centred hospital care: validation of a checklist for participatory service improvement
Authors: Cardinali F. , Carzaniga S. , Martini L. , Loiudice M. T. , Carinci Fabrizio 
Published: January 2025

Abstract

Background
In 2018, a nationwide survey carried out in 387 acute care hospitals from 16 out of 21 Italian regions, allowed defining an extended checklist for the participatory evaluation of person-centredness in hospital care. We aimed to validate a reduced set of core items for continuous use across the country.

Methods
Factor analysis was used to validate the construct of the checklist. Varimax rotation with eigenvalues > 1 was used to optimize factor structure. Items with an item-total correlation > 0.30 and factor loadings > 0.4 were attributed to individual factors. Items with inter-item correlation coefficient > 0.70 were submitted to expert opinion for final decision. Overall internal consistency was assessed through Cronbach’s alpha.

Results
A total of 183 out of 243 items in the original checklist were submitted to factor analysis. A subgroup of 67 items was retained in 4 main areas, allocated as follows: 16 items in 4 sub-areas of “Person-oriented organizational and care processes”, 16 items in 4 sub-areas of “Physical accessibility, liveability and comfort of the facilities”, 15 items in 3 sub-areas of “Access to information, streamlining and transparency”, and 20 items in 4 sub-areas of “Taking care of the relationship with patients and citizens”. Overall values of Cronbach’s alpha ranged between 0.77 and 0.90, showing high consistency.

Conclusions
This study validated a “core” checklist that can be routinely used to monitor the implementation of person-centred care in Italian hospitals. The tool can be applied more widely by multiple stakeholders as a measurement instrument for the participatory evaluation of person-centredness.
Characterization of liver, adipose, and fecal microbiome in obese patients with MASLD: links with disease severity and metabolic dysfunction parameters
Authors: Schwenger Katherine J. P. , Copeland Julia K. , Ghorbani Yasaman , Chen Lina , Comelli Elena M. , Guttman David S. , Fischer Sandra E. , Jackson Timothy D. , Okrainec Allan , Allard Johane P. 
Published: January 2025

Abstract

Background
Metabolic dysfunction-associated steatotic liver disease (MASLD) encompasses a range of histological findings from the generally benign simple steatosis to steatohepatitis (MASH) which can progress to fibrosis and cirrhosis. Several factors, including the microbiome, may contribute to disease progression.

Results
Here, we demonstrate links between the presence and abundance of specific bacteria in the adipose and liver tissues, inflammatory genes, immune cell responses, and disease severity. Overall, in MASLD patients, we observed a generalized obesity-induced translocation of gut bacteria to hepatic and adipose tissues. We identified microbial patterns unique to more severely diseased tissues. Specifically, Enterococcus, Granulicatella, and Morganellaceae abundance is positively correlated with immune cell counts and inflammatory gene expression levels, and both genera are significantly enriched in MASH patients. Brevibacterium is enriched in adipose tissues of patients with liver fibrosis.

Conclusion
Together, these results provide further insight into the microbial factors that may be driving disease severity.
Monkeypox: a re-emergent virus with global health implications – a comprehensive review
Authors: Naga Nourhan G. , Nawar Enas A. , Mobarak A’laa A. , Faramawy Aya G. , Al-Kordy Hend M. H. 
Published: January 2025

Abstract
Monkeypox virus (MPXV) is an enclosed, double-stranded DNA virus from the Orthopoxvirus genus, which also contains variola, vaccinia, and cowpox. MPXV, which was once confined to West and Central Africa, has recently had a rebound, spreading beyond its original range since 2017. The virus is distinguished by its unique morphology, which includes an oval or brick-shaped structure and a complex lipid and protein makeup. The current multi-country outbreak designated a public health emergency in 2022, has highlighted MPXV’s shifting epidemiology and ability to spread rapidly over the globe. ‘No one is safe until everyone is safe’ is a slogan we often heard during the COVID-19 pandemic, which is now also required for the growing global and regional mpox outbreaks. The epidemic is divided into two clades: Clade I and Clade II, which have distinct pathogenic characteristics. Diagnostic approaches have developed with advances in molecular techniques, yet problems persist in resource-constrained situations. This overview summarizes the virus’s history, epidemiology, morphology, and clinical characteristics, offering insights into its recent comeback and current global response efforts.
Comparison of the asymmetric multifractal behavior of green and U.S. bonds against benchmark financial assets
Authors: Kristjanpoller Werner , Tabak Benjamin Miranda 
Published: January 2025

Abstract
Presently, financial portfolio managers lack a solid basis for building a reliable risk management strategy for green debt instrument investments due to the lack of compelling growth and resilience data. Therefore, this study assesses the role of green bonds in financial markets by assessing and correlating their complex scaling behaviors across multiple periods with those of key benchmark assets (e.g., conventional bonds, high-yield bonds, Euro-Dollar exchange, Dow Jones Industrial Index, Bitcoin, and Gold). Specifically, we explore linear and nonlinear correlation patterns using cross-correlation tests and the dynamic conditional correlation model, focusing on bond interactions under various degrees of freedom. Our analysis reveals that although most assets exhibit nonlinear correlations, Bitcoin uniquely aligns linearly with U.S. bonds under certain conditions. Green bonds, however, display nonlinear correlations with Bitcoin and stand out for their distinct upward financial persistence. We find also that green bonds are primary drivers in the financial domain, highlighted by their pronounced interactions and the consistent cross-correlation with the Euro-Dollar exchange rate. Moreover, green bonds have the lowest multifractality, showing persistent upward trends and antipersistent downward trends, rendering them quite resilient during periods of high volatility. These results imply that green bonds may be advantageous to portfolio risk management strategies, especially during crises when diversification and hedging tactics are needed.
The nexus between the financial development and CO2 emissions: fresh evidence through time–frequency analyses
Authors: Bilgili Faik , Muğaloğlu Erhan , Kuşkaya Sevda , Cifuentes-Faura Javier , Khan Kamran , Alnour Mohammed 
Published: January 2025

Abstract
Climate change and environmental degradation threaten the world and global economic conditions. As one of countries’ most important economic components, the financial sector might be an effective tool for reducing and even reversing environmental degradation. The financial sector can affect sustainability through its lending and investment practices. The sector can play a role in financing sustainable projects and businesses, helping reduce CO2 emissions. By aligning its financial objectives with environmental protection, the financial sector can support the transition to a more sustainable future by helping reduce environmental degradation’s negative impacts. This paper examines the domestic financial sector’s impact on CO2 emissions in the United States over the 1990:Q1–2022:Q3 period. In this research, the nexus between the domestic financial sector (total debt securities, loans, liabilities, and total financial assets) and Carbon dioxide emissions in the U.S. is investigated by Morlet wavelet analysis. Rest of the world: sector discrepancy transactions, rest of the world: debt securities and loans, gross domestic product, and the square of the gross domestic product, are control variables in the estimated models. Partial wavelet coherency analyses prove that the financial sector reduces CO2 emissions at the 5–8-year frequency band during different subsample periods. The financial sector’s instruments can be effective in struggling with climate change.
Decoding systemic risks across commodities and emerging market stock markets
Authors: Ghallabi Fahmi , Ghorbel Ahmed , Karim Sitara 
Published: January 2025

Abstract
This study explores correlations and risk spillovers, essential concepts for financial risk management, among commodities (crude oil, gold, and a global commodities index) and emerging stock markets. Using the Asymmetric Dynamic Conditional Correlation–Conditional Value-at-Risk (ADCC-CoVaR) model and a bootstrapped Kolmogorov–Smirnov (KS) test, we analyze the period from December 30, 2005, to February 28, 2024, examining correlations, downside and upside risk spillovers, and highlighting the effects of major events such as the global financial crisis of 2008, the COVID-19 pandemic, and the Russia-Ukraine war. The results show heightened correlations during crises and significant risk spillovers across market pairs, with downside risks often outweighing upside risks. Gold displays minimal risk spillover, highlighting its unique role as a haven asset. We find that spillovers between gold, global commodities, and stocks increased during the pandemic and the Russia-Ukraine conflict, while those involving crude oil remained stable. These findings provide valuable guidance for portfolio managers in navigating volatile markets.
Evaluation of the impact of the state of emergency during the COVID-19 pandemic on childhood immunizations in Benguela Province, Angola
Authors: Imamura Tadatsugu , Mochida Keiji , Olukunmi Balogun , Tchicondingosse Lino , Sapalalo Pedro , Francisco Ketha Rubuz , Aoki Ai , Ishiguro Akira , Takehara Kenji 
Published: January 2025

Abstract

Background
The impact of public health measures against the coronavirus disease 2019 on the rate of childhood immunization has not yet been fully defined. Particularly, measures which directly affect health-seeking behaviors (e.g., the State of Emergency; SoE) drew public health attention. We aim to describe this impact in Benguela Province, Angola, by comparing the immunization rates between infants who had their immunizations before and after the SoE, which was declared on March 27, 2020.

Methods
We retrospectively reviewed the epidemiological data of infants born between November 2019 and February 2020 in Benguela Province, Angola. Immunization rates (i.e., the number of immunized infants divided by the number of infants in the group of same months of birth and residential areas) were calculated for 11 vaccines that infants received from at birth to the 4th month after birth. The rates for the 2nd month vaccines were compared between infants immunized before the SoE (post-SoE), and after the SoE (pre-SoE).

Results
Among 9,595 infants, the overall immunization rates were higher in the post-SoE (71.9–77.8%) than in the pre-SoE groups (66.0–73.8%). The overall immunization rates were higher in the post-SoE group than in the pre-SoE group in both urban and rural municipalities, although the rates were > 20% higher in urban than in rural municipalities. The immunization rates in the recommended month showed a similar trend, except for the stratified analysis for rural municipalities, where the rates were 2.3–4.1% lower in the post-SoE than in the pre-SoE groups.
The most common reason for missing immunization was vaccine unavailability at health units (19.9%, 684/3,440). Less than 10% of missed immunizations were due to the SoE, which occurred mostly in infants born in rural municipalities in February 2020 (9.8%, 52/532). Less than 2% of missed immunizations were due to health units not being open, and was highest in rural municipalities in January 2020 (1.6%, 27/1,673).

Conclusions
Our study suggested that the disruptive impacts of public health measures against pandemics on rates of childhood immunization can be mitigated, and support is needed for areas with vulnerable health systems, such as rural areas.
Effects of population aging on quality of life and disease burden: a population-based study
Authors: Xi Jun-Yan , Liang Bo-Heng , Zhang Wang-Jian , Yan Bo , Dong Hang , Chen Yuan-Yuan , Lin Xiao , Gu Jing , Hao Yuan-Tao 
Published: January 2025

Abstract

Background
As population aging intensifies, it becomes increasingly important to elucidate the casual relationship between aging and changes in population health. Therefore, our study proposed to develop a systematic attribution framework to comprehensively evaluate the health impacts of population aging.

Methods
We used health-adjusted life expectancy (HALE) to measure quality of life and disability-adjusted life years (DALY) to quantify the burden of disease for the population of Guangzhou. The HALE and DALY projections were generated using both the Bayesian age-period-cohort models and the population prediction models. Changes in HALE and DALY between 2010–2020 and 2020–2030 were decomposed to isolate the effects of population aging. Three scenarios were analyzed to examine the relative relationship between disease burden and population aging. In Scenarios 1 and 2, the disease burden rates in 2030 were assumed to either remain at 2020 levels or follow historical trends. In Scenario 3, it was assumed that the absolute numbers of years of life lost (YLL) and years lived with disability (YLD) in 2030 would remain unchanged from the 2020 levels.

Results
Between 2010 and 2020, 56.24% [69.73%] of the increase in male [female, values in brackets] HALE was attributable to the mortality effects in the population aged 60 and over, while − 3.74% [− 9.29%] was attributable to the disability effects. The increase in DALY caused by changes in age structure accounted for 72.01% [46.68%] of the total increase in DALY. From 2020 to 2030, 61.43% [69.05%] of the increase in HALE is projected to result from the mortality effects in the population aged 60 and over, while − 3.88% [4.73%] will be attributable to the disability effects. The increase in DALY due to changes in age structure is expected to account for 102.93% [100.99%] of the total increase in DALY. In Scenario 1, YLL are projected to increase by 45.0% [54.7%], and YLD by 31.8% [33.8%], compared to 2020. In Scenario 2, YLL in 2030 is expected to decrease by − 2.9% [− 1.3%], while YLD will increase by 12.7% [14.7%] compared to 2020. In Scenario 3, the expected YLL rates and YLD rates in 2030 would need to be reduced by 15.3% [15.4%] and 15.4% [15.6%], respectively, compared to 2020.

Conclusions
The disability effects among the elderly population hinder improvements in quality of life, while changes in age structure are the primary driver of disease burden accumulation. To mitigate the excess disease burden caused by population aging, it is essential to achieve a reduction of more than 15% in the disease burden by 2030 compared to 2020. Our proposed attribution framework evaluates the health impacts of population aging across two dimensions: quality of life and disease burden. This framework enables comparisons of these effects over time and across different regions.
Selection of appropriate probiotic yeasts for use in dairy products: a narrative review
Authors: Kazemi Sanaz , Homayouni-Rad Aziz , Samadi Kafil Hossien , Sarabi-aghdam Vahideh , Zeynolabedini Payam , pour Agha Bahareh , Allah Madadi Sevda 
Published: January 2025

Abstract
Yeasts, with a history of approximately 5,000 years in food and medicinal applications, play a vital role in various industries. The advantages of these microorganisms include probiotic effects, phytate biodegradation, mycotoxin breakdown, and adsorption capabilities. Traditionally, research on probiotics has primarily focused on lactic acid bacteria and bifidobacteria; however, there is a growing global interest in incorporating yeast as a probiotic supplement. Notably, yeast species such as Saccharomyces, Candida, Debaryomyces, Yarrowia, and Kluyveromyces have been identified for their probiotic potential. These probiotic yeasts are commonly introduced into dairy products, including kefir, yogurt, kumis, and cheese. However, the compatibility of probiotic yeasts with dairy matrices, as well as the factors influencing their viability and functionality, remains a critical area of study. Ongoing research focused on exploring techniques to enhance yeast viability during processing, given that different strains may exhibit varying survival rates and probiotic properties. Consequently, probiotic yeasts represent a promising avenue for augmenting the health benefits of dairy products. This development prompts essential discussions regarding selecting suitable probiotic yeasts for specific dairy applications. This paper comprehensively examines the historical discovery, types, properties, and applications of probiotic yeasts in dairy products. It aims to shed light on their health effects while addressing the challenges associated with selecting the appropriate probiotic yeast to optimize the enhancement of dairy products.

Graphical Abstract
Awareness and attitudes of pregnant women concerning genetic disorders and pregnancy termination in northeastern Iran
Authors: Todarbary Nafiseh , Irandegani Abouzar , Meshkat Mojtaba , Gholoobi Aida , Hamzehloei Tayebeh 
Published: January 2025

Abstract

Background
Genetic disorders are common in the Eastern Mediterranean region due to the high prevalence of consanguineous marriages. This study explores the awareness and attitudes of pregnant women in Mashhad, the biggest city in northeastern Iran, toward genetic disorders and the decision-making process regarding pregnancy termination. This study included 297 pregnant women across five hospitals in Mashhad, Iran. They filled out a checklist comprised of demographic data and questions about abortion decisions facing a child with various genetic disorders or undesired gender.

Results
The majority (75%) agreed with abortion in cases of anencephaly, while only 19% accepted it for undesired gender. Education level was associated with abortion agreement for various conditions, including cleft lip or palate, Alzheimer’s disease, Turner syndrome, cystic fibrosis, phenylketonuria, Huntington’s disease, autism, fragile X syndrome, and epilepsy. Additionally, the number of children was correlated with congenital blindness, Duchenne muscular dystrophy, autism, Proteus syndrome, Klinefelter syndrome, anencephaly, mental retardation (MR), quadriplegia, and severe learning disability and mental health (LDMH). Age was associated with conditions such as epilepsy, congenital blindness, schizophrenia, and severe LDMH. Furthermore, a history of anomalies in previous pregnancies was linked to Klinefelter syndrome, Turner syndrome, dwarfism, and quadriplegia. The number of pregnancies was also correlated with severe LDMH, dwarfism, and Klinefelter syndrome, while job status was related to epilepsy, Alzheimer’s disease, and dwarfism.

Conclusion
The findings emphasize the importance of comprehensive genetic counseling, informed decision-making in prenatal care, advocating for policy reviews, and culturally sensitive guidelines in Iran.
Early applicability of retinopathy of prematurity score (ROPScore) and serum insulin growth factor-1 (IGF-1) for predicting treatment-requiring retinopathy of prematurity: a prospective cohort study
Authors: Ali Aliaa Adel , Gomaa Nancy Abd El-Salam Ahmed , Kamil Basma Samir , Awadein Ahmed , Baz Heba , Elmazzahy Esraa Ahmed 
Published: January 2025

Abstract

Background
Retinopathy of prematurity is a leading cause of blindness especially in developing countries where the accessibility to screening may not be available. Therefore, early prediction could help reallocate the resources for those at high risk.

Objectives
This study aimed to evaluate the accuracy of the retinopathy of prematurity score (ROPScore) and serum insulin-like growth factor-1 (IGF-1) for predicting treatment-requiring retinopathy of prematurity.

Methods
This prospective cohort study included 87 preterm neonates (≤ 32 weeks). Neonates were screened using digital fundus photography with indirect ophthalmoscopy performed when retinopathy of prematurity changes was detected. Serum insulin-like growth factor-1 was measured in the 3rd week of life.

Results
Nine cases (10.3%) developed treatment-requiring retinopathy of prematurity, while 78 patients had mild retinopathy of prematurity. According to logistic regression analysis, lower birth weight and longer duration of assisted ventilation were independent risk factors for treatment-requiring retinopathy of prematurity. At the 2nd week of life, cut-off value of 14.95 for the retinopathy of prematurity score showed a sensitivity of 100% and a specificity of 67.9% for predicting treatment-requiring retinopathy of prematurity. Moreover, serum insulin-like growth factor-1 was significantly lower in patients with treatment-requiring retinopathy of prematurity (p < 0.001).

Conclusions
ROPScore applied at week 2 and week 6 of life showed the same sensitivity and specificity to predict treatment-requiring retinopathy of prematurity. Furthermore, serum insulin-like growth factor-1 in the 3rd week of life was significantly lower in patients with treatment-requiring retinopathy of prematurity.
Stability indicating eco-friendly HPLC method development and validation for the estimation of bisoprolol fumarate and telmisartan
Authors: Darji Hitanshi , Prajapati Pratima , Dedania Zarna , Dedania Ronak 
Published: January 2025

Abstract

Background
Telmisartan and bisoprolol fumarate together are two medications that diminish arterial pressure. The current study comprises an evaluation of the proposed methodology's greenness regarding the HPLC method used to govern the medication mixture regardless of dose form A novel stability suggesting HPLC method's environmental effect was evaluated using the greenness metrics. Stress conditions comprising acidic, alkaline, oxidative, thermal, and photolytic degradation were applied for both of the medications.

Results
The RP—HPLC method employing a reversed-phase C18 column with a gradient approach, the HPLC chromatography was carried out. The mobile phase consisted of acetonitrile, methanol, and phosphate buffer (60:35:5, %v/v/v), with the stationary phase being the Unisphere C18 column Agela Tech. The RP-HPLC method uses UV detection at 224 nm with chromatographic purification spanning linearities of 2.5–12.5 μg/mL for bisoprolol fumarate and 40.0–200.0 μg/mL for telmisartan, correspondingly. The procedure is accurate and precise, as demonstrated by an outcome that % RSD inside the permissible range. Additionally, various stressors were introduced to the medications. The approach's green credentials with respect to solvent utilization, chemical substances, expenditure of energy, and waste formation have been verified by the greenness data collected during the evaluation. No chromatographic or spectrum impediments caused by formulation additives have been observed.

Conclusion
Bisoprolol fumarate and telmisartan could be measured simultaneously using the devised RP-HPLC method, which was simple, quick, sensitive, accurate, precise, linear, and stability indicating. The proposed approach showed ecological friendliness, robustness, sensitivity, and ease of use. As a result, the devised method could be applied to the regular quality checking of tablets and bulk medications.