bluuebunny/crossref_metadata_2025_split huggingface dataset:
Health tourism and government supports
Authors: Shabankareh Mohammadjavad , Nazarian Alireza , Golestaneh Mohammad Hassan , Dalouchi Fereshteh 
Published: July 2023

PurposeHealth tourism is a relatively new branch of international tourism that has developed more rapidly than other tourism sectors in recent years. This study aimed to investigate the effect of government supports on health tourism development by considering the mediating role of internal and external infrastructures.Design/methodology/approachThe study population consisted of all experts of two hospitals in Iran, which are frequently visited by foreign tourists (N = 151). A questionnaire, developed by combining standard and researcher-made questionnaires, was used to collect the data. The confirmatory factor analysis (CFA) model was developed in SmartPLS 3 to test the hypotheses.FindingsThe main hypothesis test results indicated that government supports positively affect the development of health tourism. Internal and external infrastructures were also found to mediate the relationship between government supports and health tourism development. In addition, the sub-hypothesis test results showed that internal and external infrastructures are positively affected by government supports, which puts forth the development of health tourism. As the results explained, the most important aspects of internal infrastructures affected by government support were health service quality, cost of health services and applying advanced medical technologies, respectively. Also, different aspects of external infrastructures affected by government supports are as follows: economic, infrastructures and cultural factors.Originality/valueThis study is the first of its kind to examine the impact of both medical and non-medical factors on health tourism and signifies the crucial role of governments in the development of health tourism.
Does the adoption of blockchain technology add intangible benefits to the industrial sector? Evidence from Jordan
Authors: Jaradat Zaid , Al-Hawamleh Ahmad , Al Shbail Mohannad Obeid , Hamdan Allam 
Published: July 2023

Purpose
This study aims to examine the feasibility of adopting blockchain technology in Jordan’s industrial sector and its intangible benefits. It also analyzes the influence of factors like technological, process, cultural and leadership readiness on the willingness of enterprises to adopt blockchain.

Design/methodology/approach
To gain insights into the potential adoption of blockchain technology and its intangible benefits for enterprises in the Jordanian industrial sector, this study gathered perspectives from a broad range of professionals, including financial managers, internal control staff, accounting departments, IT department managers and IS-related personnel. This was achieved through the administration of a comprehensive questionnaire designed to capture their opinions.

Findings
This study highlights the importance of technological and leadership readiness in adopting blockchain. It also shows that blockchain adoption can yield significant intangible benefits for enterprises. However, the study did not find a significant relationship between process readiness, cultural readiness and the intention to adopt blockchain.

Practical implications
The study’s outcomes underscore the importance of prioritizing technological and leadership readiness for enterprises and policymakers intending to adopt blockchain technology. By doing so, they can increase their willingness to adopt this technology and leverage its benefits.

Originality/value
This pioneering study investigates the adoption of blockchain technology and its intangible benefits for Jordanian businesses. It also examines the influence of factors like technological, process, cultural and leadership readiness on the decision to adopt blockchain in the industrial sector.
Digging behind the scenes: prioritizing human resources practices related to hospitality employees' attitudes and behaviors after the COVID-19 pandemic
Authors: Elsayed Yousery Nabil M.K. , Khreis Sawsan Haider , Abuelhassan Abuelhassan Elshazly , Abdelgawwad Mohamed Abdelgawwad Aly 
Published: July 2023

PurposeThis study aims to provide a new vision for investigating the different human resources management (HRM) practices in hotels after the COVID-19 pandemic.Design/methodology/approachA quantitative research approach was adopted using confirmatory factor analysis and structural equation modeling to reveal updated priorities and relations as stated by 504 hospitality employees.FindingsThe research approach contributed to highlighting exciting findings, as training and development (T&D) had an insignificant effect on turnover intention (IT) or affective organizational commitment (AOC) following the COVID-19 pandemic; job security (JS) had the highest impact on AOC and compensation had the highest effect on TI.Practical implicationsIndividual HRM practices have different strong impacts on employee outcomes. This paper provides human resource directors with realistic and practical implications to boost individuals' AOC and reduces their intention to quit their job in conditions of uncertainty and ambiguity.Originality/valueThis pioneering study reveals the influence of HRM practices in the hospitality HRM systems regarding employee attitudes and behaviors, especially after the COVID-19 pandemic. It provides novel theoretical and practical contributions.
Towards an experiential identity of place: the case of Manchester’s Craft and Design Centre
Authors: Skandalis Alexandros 
Published: July 2023

Purpose
The aim of this paper is to explore the role and potential of lived experiences in informing and shaping the formation of place identity within the sphere of the production and consumption of craft objects.

Design/methodology/approach
This paper is part of a larger funded research project and focuses on Manchester’s Craft and Design Centre. It draws upon a series of in-depth interviews conducted with craft makers and visitors.

Findings
The analysis and interpretation of textual data help to theorise an experiential identity of place, which revolves around the fusion of the cultural heritage and lived insideness of the physical setting; activity spaces and the micro-encounters of craft-making; and conflicting meanings and attachments to the Craft and Design Centre.

Originality/value
This study provides a novel perspective on the understanding of place identity in the context of craft-making by focusing on the lived experiences of various stakeholders and acknowledging the multi-faceted, dynamic and processual nature of place.
The predicting role of knowledge-based dynamic capabilities on innovation performance of small enterprises in Tanzania: mediating effect of innovation culture
Authors: Ismail Ismail Juma 
Published: July 2023

PurposeThe main purpose of this study is to investigate the mediating role of innovation culture in the relationship between knowledge-based dynamic capabilities and innovation performance of small enterprises in Tanzania.Design/methodology/approachThis study is cross-sectional and data collected through structured questionnaire were analyzed using PLS-SEM.FindingsThe findings revealed that dimensions of knowledge-based dynamic capabilities significantly influence innovation culture and innovation culture significantly influence the innovation performance. Finally, innovation culture is a significant mediator of the relationship.Practical implicationsThe study contributes to the understanding that owners of small businesses must create conducive environments for the development of an innovation culture by improving knowledge acquisition, generation and combination for better innovation performance outcomes.Originality/valueStudies done on innovation culture are limited especially in the context of developing countries such as Tanzania where adoption of innovative ideas is considered a slow process due to various factors such as poor management of knowledge resources. Therefore, this study contributes to the body of knowledge by establishing a link between knowledge-based dynamic capabilities and innovation performance through a mediation of innovation culture.
Phase 1 safety, tolerability, pharmacokinetics and pharmacodynamic results of KCL‐286, a novel retinoic acid receptor‐β agonist for treatment of spinal cord injury, in male healthy participants
Authors: Goncalves Maria B. , Mant Tim , Täubel Jörg , Clarke Earl , Hassanin Hana , Bendel Daryl , Fok Henry , Posner John , Holmes Jane , Mander Adrian P. , Corcoran Jonathan P. T. 
Published: July 2023

AimsKCL‐286 is an orally available agonist that activates the retinoic acid receptor (RAR) β2, a transcription factor which stimulates axonal outgrowth. The investigational medicinal product is being developed for treatment of spinal cord injury (SCI). This adaptive dose escalation study evaluated the tolerability, safety and pharmacokinetics and pharmacodynamic activity of KCL‐286 in male healthy volunteers to establish dosing to be used in the SCI patient population.MethodsThe design was a double blind, randomized, placebo‐controlled dose escalation study in 2 parts: a single ascending dose adaptive design with a food interaction arm, and a multiple ascending dose design. RARβ2 mRNA expression was evaluated in white blood cells.ResultsAt the highest single and multiple ascending doses (100 mg), no trends or clinically important differences were noted in the incidence or intensity of adverse events (AEs), serious AEs or other safety assessments with none leading to withdrawal from the study. The AEs were dry skin, rash, skin exfoliation, raised liver enzymes and eye disorders. There was an increase in mean maximum observed concentration and area under the plasma concentration–time curve up to 24 h showing a trend to subproportionality with dose. RARβ2 was upregulated by the investigational medicinal product in white blood cells.ConclusionKCL‐286 was well tolerated by healthy human participants following doses that exceeded potentially clinically relevant plasma exposures based on preclinical in vivo models. Target engagement shows the drug candidate activates its receptor. These findings support further development of KCL‐286 as a novel oral treatment for SCI.
The RAPIDO trial—Reduction in disease‐related treatment failure does not translate into improved overall survival: a mystery solved!
Authors: Ballal Devesh , Raj Prudvi , Saklani Avanish P. 
Published: July 2023

AbstractThe initial publication of the RAPIDO trial resulted in widespread adoption of short‐course radiotherapy and consolidation chemotherapy in locally advanced rectal cancer. The impressive reduction in disease‐related treatment failure did not, however, translate into any overall survival benefit. The recent update of the RAPIDO trial with its 5‐year results provides much insight into the actual effect that this approach has on patient outcomes and the detriment in local control leads to the question as to whether this approach can still be considered as standard of care in high‐risk rectal cancer.
In‐hospital outcomes in patients with and without epilepsy diagnosed with COVID‐19—A cohort study
Authors: Ufongene Claire , Van Hyfte Grace , Agarwal Parul , Blank Leah J. , Goldstein Jonathan , Mathew Brian , Lin Jung‐Yi , Navis Allison , McCarthy Louise , Gururangan Kapil , Peschansky Veronica , Kwon Churl‐Su , Cohen Ariella , Chan Andy Ho Wing , Dhamoon Mandip , Deng Pojen , Gutzwiller Eveline M. , Hao Qing , He Celestine , Heredia Nunez Wilson D. , Klenofsky Britany , Lemus Hernan Nicolas , Marcuse Lara , Roberts Mallory , Schorr Emily M. , Singh Anuradha , Tantillo Gabriela , Young James , Balchandani Priti , Festa Joanne , Naasan Georges , Charney Alexander , Nadkarni Girish , Jetté Nathalie 
Published: July 2023

AbstractObjectivesCoronavirus disease 2019 (COVID‐19) is associated with mortality in persons with comorbidities. The aim of this study was to evaluate in‐hospital outcomes in patients with COVID‐19 with and without epilepsy.MethodsWe conducted a retrospective study of patients with COVID‐19 admitted to a multicenter health system between March 15, 2020, and May 17, 2021. Patients with epilepsy were identified using a validated International Classification of Diseases, Ninth Revision, Clinical Modification (ICD‐9‐CM)/ICD‐10‐CM case definition. Logistic regression models and Kaplan–Meier analyses were conducted for mortality and non‐routine discharges (i.e., not discharged home). An ordinary least‐squares regression model was fitted for length of stay (LOS).ResultsWe identified 9833 people with COVID‐19 including 334 with epilepsy. On univariate analysis, people with epilepsy had significantly higher ventilator use (37.70% vs 14.30%, p < .001), intensive care unit (ICU) admissions (39.20% vs 17.70%, p < .001) mortality rate (29.60% vs 19.90%, p < .001), and longer LOS (12 days vs 7 days, p < .001). and fewer were discharged home (29.64% vs 57.37%, p < .001). On multivariate analysis, only non‐routine discharge (adjusted odds ratio [aOR] 2.70, 95% confidence interval [CI] 2.00–3.70; p < .001) and LOS (32.50% longer, 95% CI 22.20%–43.60%; p < .001) were significantly different. Factors associated with higher odds of mortality in epilepsy were older age (aOR 1.05, 95% CI 1.03–1.08; p < .001), ventilator support (aOR 7.18, 95% CI 3.12–16.48; p < .001), and higher Charlson comorbidity index (CCI) (aOR 1.18, 95% CI 1.04–1.34; p = .010). In epilepsy, admissions between August and December 2020 or January and May 2021 were associated with a lower odds of non‐routine discharge and decreased LOS compared to admissions between March and July 2020, but this difference was not statistically significant.SignificancePeople with COVID‐19 who had epilepsy had a higher odds of non‐routine discharge and longer LOS but not higher mortality. Older age (≥65), ventilator use, and higher CCI were associated with COVID‐19 mortality in epilepsy. This suggests that older adults with epilepsy and multimorbidity are more vulnerable than those without and should be monitored closely in the setting of COVID‐19.
Factors associated with the unmet needs of parents of children with autism in Qatar
Authors: Ekas Naomi V. , Badahbah Abdallah , Abdelmoneium Azza O. 
Published: July 2023

AbstractObjectiveThe current study examined whether the unmet needs of parents of children with autism in Qatar predicted parent well‐being and whether sociodemographic factors and child characteristics were associated with parental unmet needs.BackgroundParents of children with autism have unmet needs that may negatively impact family members. There is little research examining unmet needs outside Europe or North America.MethodParticipants of this cross‐sectional, correlational study were 41 parents of a child with autism residing in Qatar. Parents completed surveys in Arabic about their sociodemographic characteristics, their unmet needs, their well‐being, social support, and their child's behavior.ResultsRegression analyses were performed to test the research questions. Greater unmet needs were a significant predictor of life satisfaction. Child behavior problems were a significant predictor of unmet needs, namely the need for family support and help explaining their child's diagnosis to others.ConclusionsThe findings suggest that the unmet needs of parents of children with autism are negatively associated with life satisfaction and are heightened in families where children have more behavior problems.ImplicationsThe Qatar government developed a national plan for autism and our results underscore the need to implement programs to support families of children with autism. An important first step is to ensure that developmentally appropriate information is provided to families and to facilitate connections between families and other stakeholders (e.g., other parents and service providers) in their community.
Effect of surface treatment upon luminous efficiency of YAG: Ce ceramics
Authors: Li Yanan , Zhang Haitao , Ling Junrong , Yang Jian , Xu Wentao , Zhou Youfu , Hong Maochun 
Published: July 2023

AbstractFor high‐power white light‐emitting diode devices (WLEDs), phosphor ceramics were widely used because of their high thermal conductivity and temperature resistance. In this study, Y2.998Al5O12: 0.002Ce3+ ceramics were prepared via vacuum reaction sintering and treated by silicon carbide (SiC) abrasives with particle sizes of 8.6, 20, 25, 34, and 50 μm to obtain a single textured surface. The transmittance, reflectance, luminous efficiency (LE) and photoluminescence (PL) intensity of the ceramics were investigated with various surface roughness and different placement. Compared with the double polished (DP) samples, the PL intensity and LE of the single‐surface textured ceramics were greatly improved. It was shown that the roughest ceramics placed with the single polished (SP) side facing the direction of the excitation light (the SP‐forward YAG: Ce ceramics) showed the best performance.
A randomized prospective study to assess the role of topical tacrolimus as preventive therapy in unstable acral vitiligo
Authors: Kumar Deepak , Thakur Vishal , Subburaj Kiruthika , Bishnoi Anuradha , Vinay Keshavamurthy , Sendhil Kumaran Muthu , Parsad Davinder 
Published: July 2023

AbstractBackgroundAcral vitiligo is a significantly distressing condition and tends to be treatment‐resistant. The occurrence of new lesions on acral areas further causes greater psychological trauma. Topical tacrolimus has been widely used in the management of vitiligo and its role in preventing flares in other dermatoses such as atopic dermatitis has been well documented.ObjectivesTo assess the role of topical tacrolimus as preventive therapy in unstable acral vitiligo.Materials and MethodsIn this single‐centre randomized prospective study, 60 patients aged 16–60 years having unstable acral vitiligo with symmetrical lesions were enrolled and randomized (1:1) into two groups. Patients in group A were instructed to apply topical tacrolimus 0.1% ointment on both vitiliginous and normal skin while patients in group B were instructed to apply topical tacrolimus 0.1% ointment only on vitiliginous skin for 6 months. Only the distal hand till the wrist joint was chosen for observation. Vitiliginous patches were assessed monthly for 6 months for a change in the number of lesions and total area involved, extension of preexisting lesions and adverse effects if any.ResultsA reduction in the number of lesions was observed in both groups. The decrease in the number of lesions in group A was 5.6% as compared to 2.3% in group B (p‐0.001). The decrease in depigmented area in group A was 10.5% as compared to 4.6% in group B (p‐0.048). Treatment failure was seen in 11 out of 60 (18.3%) patients.ConclusionTacrolimus 0.1% ointment application showed effectiveness in preventing the appearance of new lesions in unstable acral vitiligo and hastening the repigmentation when applied on both lesional and perilesional skin in vitiligo.
First record of skipper genus Ochlodes scudder, 1872 (Lepidoptera: Hesperiidae) feeding on rice, with a note on the taxonomy of Ochlodes sylvanus hyrcana (Christoph, 1893) stat. rev.
Authors: Farahpour‐Haghani Atousa , Jalaeian Mahdi , Nazari Vazrick 
Published: July 2023

AbstractWe report the first record of the larvae of a species in the butterfly genus Ochlodes (Lepidoptera: Hesperiidae) feeding on rice and causing notable damage. Based on the results of DNA barcoding of the reared adults and further investigation of male and female genitalia, we revise the status of taxon hyrcana Christoph, 1893 as a subspecies of Ochlodes sylvanus (Esper, [1778]) stat. rev.
Durvalumab plus gemcitabine and cisplatin in advanced biliary tract cancer: An early exploratory analysis of real‐world data
Authors: Rimini Margherita , Fornaro Lorenzo , Lonardi Sara , Niger Monica , Lavacchi Daniele , Pressiani Tiziana , Lucchetti Jessica , Giordano Guido , Pretta Andrea , Tamburini Emiliano , Pirrone Chiara , Rapposelli Ilario Giovanni , Diana Anna , Martinelli Erika , Garajová Ingrid , Simionato Francesca , Schirripa Marta , Formica Vincenzo , Vivaldi Caterina , Caliman Enrico , Rizzato Mario Domenico , Zanuso Valentina , Nichetti Federico , Angotti Lorenzo , Landriscina Matteo , Scartozzi Mario , Ramundo Matteo , Pastorino Alessandro , Daniele Bruno , Cornara Noemi , Persano Mara , Gusmaroli Eleonora , Cerantola Riccardo , Salani Francesca , Ratti Francesca , Aldrighetti Luca , Cascinu Stefano , Rimassa Lorenza , Antonuzzo Lorenzo , Casadei‐Gardini Andrea 
Published: July 2023

AbstractBackgroundThe TOPAZ‐1 phase III trial reported a survival benefit with the anti‐programmed death cell ligand 1 (anti‐PD‐L1) durvalumab in combination with gemcitabine and cisplatin in patients with advanced biliary tract cancer. The present study investigated the efficacy and safety of this new standard treatment in a real‐world setting.MethodsThe analysed population included patients with unresectable, locally advanced or metastatic adenocarcinoma of the biliary tract treated with durvalumab in combination with gemcitabine and cisplatin at 17 Italian centres. The primary endpoint of the study was progression‐free survival (PFS), whereas secondary endpoints included overall survival (OS), overall response rate (ORR) and safety. Unadjusted and adjusted hazard ratios (HRs) by baseline characteristics were calculated using the Cox proportional hazards model.ResultsFrom February 2022 to November 2022, 145 patients were enrolled. After a median follow‐up of 8.5 months (95% CI: 7.9–13.6), the median PFS was 8.9 months (95% CI: 7.4–11.7). Median OS was 12.9 months (95% CI: 10.9–12.9). The investigator‐assessed confirmed ORR was 34.5%, and the disease control rate was 87.6%. Any grade adverse events (AEs) occurred in 137 patients (94.5%). Grades 3–4 AEs occurred in 51 patients (35.2%). The rate of immune‐mediated AEs (imAEs) was 22.7%. Grades 3–4 imAEs occurred in 2.1% of the patients. In univariate analysis, non‐viral aetiology, ECOG PS >0 and NLR ≥3 correlated with shorter PFS.ConclusionThe results reported in this first real‐world analysis mostly confirmed the results achieved in the TOPAZ‐1 trial in terms of PFS, ORR and safety.