bluuebunny/crossref_metadata_2025_split huggingface dataset:
Revealing new physics in $${\varvec{B}}^{0}_{s}\rightarrow D_s^{\mp } K^{\pm }$$ decays
Authors: Fleischer Robert , Malami Eleftheria 
Published: May 2023

AbstractThe $$B^0_s\rightarrow D_s^{\mp } K^{\pm }$$

B
s
0

→

D
s
∓

K
±

system offers a determination of the Unitarity Triangle angle $$\gamma $$
γ
. Intrigued by an LHCb analysis showing a surprisingly large result in tension with information on the Unitarity Triangle and other $$\gamma $$
γ
measurements, we make a transparent study of the measured observables, confirming the LHCb picture. The corresponding $$\gamma $$
γ
puzzle at the $$3\sigma $$

3
σ

level would require CP-violating contributions of New Physics, which should also manifest themselves in the corresponding decay branching ratios. Indeed, we find that the rates of the individual $$B^0_s\rightarrow D_s^{\mp } K^{\pm }$$

B
s
0

→

D
s
∓

K
±

channels show puzzling patterns, in accordance with similar decays, with tensions up to $$4.8\sigma $$

4.8
σ

, thereby making the situation much more exciting. We present a formalism to include New-Physics effects in a model-independent way and apply it to the data to constrain the corresponding parameters. Interestingly, new contributions of moderate size could accommodate the data. Utilising this formalism in the future high-precision B physics era may allow us to finally establish new sources of CP violation.
Sub-Character Tokenization for Chinese Pretrained Language
Models
Authors: Si Chenglei , Zhang Zhengyan , Chen Yingfa , Qi Fanchao , Wang Xiaozhi , Liu Zhiyuan , Wang Yasheng , Liu Qun , Sun Maosong 
Published: May 2023

Abstract
Tokenization is fundamental to pretrained language models (PLMs). Existing tokenization methods for Chinese PLMs typically treat each character as an indivisible token. However, they ignore the unique feature of the Chinese writing system where additional linguistic information exists below the character level, i.e., at the sub-character level. To utilize such information, we propose sub-character (SubChar for short) tokenization. Specifically, we first encode the input text by converting each Chinese character into a short sequence based on its glyph or pronunciation, and then construct the vocabulary based on the encoded text with sub-word segmentation. Experimental results show that SubChar tokenizers have two main advantages over existing tokenizers: 1) They can tokenize inputs into much shorter sequences, thus improving the computational efficiency. 2) Pronunciation-based SubChar tokenizers can encode Chinese homophones into the same transliteration sequences and produce the same tokenization output, hence being robust to homophone typos. At the same time, models trained with SubChar tokenizers perform competitively on downstream tasks. We release our code and models at https://github.com/thunlp/SubCharTokenization to facilitate future work.
Informing critical indigenous health education through critical reflection: A qualitative consensus study
Authors: Rame Ana , Kelly-Turner Kenna , Roze des Ordons Amanda , de Groot Janet , Keegan David , Crowshoe Lynden , Henderson Rita , Roach Pamela 
Published: May 2023

Objective: To examine experiences of anti-Indigenous racism in a Canadian medical school and inform the development of critical and action-oriented Indigenous health education necessary to pave the way for reconciliation within health systems. Design: A qualitative study conducted within a constructivist paradigm which involved (1) semi-structured interviews with students, faculty and staff at a Canadian medical school and (2) consensus-building/collaborative analytical sessions with an Indigenous advisory group and a non-Indigenous working group. Setting: Twenty-three semi-structured interviews were completed with students, staff and faculty working across a Canadian medical school. Results: Inductive coding generated 211 codes that were grouped into seven overarching thematic domains. By engaging in an iterative dialogue with the advisory and working groups, we deductively aligned the thematic analysis with faculty-level and institution-level Indigenous education strategies to ensure local relevance. Self-reflective statements were developed with the advisory group to guide areas for action and resulted in 18 statements with five-point Likert-type-style response options. Conclusion: The results of this study suggest that promoting self-reflexivity in health professional education can prompts educators to engage with Indigenous health curriculum and pedagogy; mentorship and role modelling; and accountability. Critically evaluating systemic injustices at an individual level enables educators to resist systemic oppression and create change in the spaces where they work.
“Are You Saying That We’re Racist?”: Comparing Normative, Political, and Technical Dimensions of Instructional and Disciplinary Policies
Authors: Daramola Eupha Jeanne , Allbright Taylor N. , Marsh Julie A. 
Published: May 2023

Background: In recent years, school districts have experienced a complex policy environment with myriad reforms aimed at addressing longstanding and historically entrenched disparities in opportunities and outcomes between racially minoritized students and White students. One such reform is standards-based accountability, with its emphasis on documenting and addressing racial disparities in testing outcomes. Recently, educators and lawmakers have sought to address persistent racial disproportionality in disciplinary actions. New behavioral policies may be seen as a response to national attention and outrage regarding the “school-to-prison pipeline,” which indicates that school discipline practices contribute to the over-representation of Black men in the criminal justice system. In recent years, local leaders have been tasked with implementing new disciplinary reforms alongside their ongoing efforts at instructional improvement. Purpose: As districts face an increasingly complex policy environment and constrained resources, researchers must understand how district leaders make sense of and manage the varied policies they are tasked with implementing. This study contributes to the knowledge base on K–12 policy implementation by examining how school district leaders manage multiple policies—particularly when some new practices engage beliefs around racial discrimination or structural racism. We contribute to the gap in the literature by asking: What differences emerged in the early implementation processes of an instructional policy and a discipline policy in the Elmwood school district, and what might explain those differences? Research Design: To answer this question, we employ a comparative, embedded case study design and examine extensive qualitative data from a single school district. Oakes’s (1992) framework of technical, normative, and political dimensions of policy change guided the analysis and was applied to rich interview data. Conclusions: Overall, our findings highlight significant differences in how Elmwood leadership implemented the two policies. Our study indicates that though both instructional and disciplinary reforms purport to address racial outcome gaps, district leaders may view discipline in a racialized way that they do not view instructional policy. The perceived racialized nature of discipline policy may significantly influence implementation practices. Ultimately, the data suggests that racialized normative beliefs and values, along with political and technical investments, greatly influence the implementation process and raise larger questions about the role of racism in education reform.
Community perspectives on the appropriateness and importance of support goals for young autistic children
Authors: Waddington Hannah , Minnell Hannah , Patrick Lee , van Der Meer Larah , Monk Ruth , Woods Lisa , Whitehouse Andrew JO 
Published: May 2023

There is little research regarding autistic adult, parent and professional perspectives on support goals for young autistic children. A total of 87 autistic adults, 159 parents of autistic children, and 80 clinical professionals living in New Zealand and Australia completed a survey about the appropriateness and importance of common support goals for young autistic children. Goals related to the adult supporting the child, the reduction and replacement of harmful behaviours, and improving child quality of life were the highest priority across participant groups, while goals related to child autism characteristics, play and academic skills were the lowest priority. Compared to parents and/or professionals, autistic adults gave lower priority ratings for play skills, autism characteristics and participation goals and were more likely to rate these goal domains as inappropriate. More research is needed to understand the underlying reasons for these similarities and differences. Lay abstract Researchers do not know much about what autistic adults, parents and professionals think about support goals for young autistic children. People’s views of support goals might also be influenced by their beliefs about early support more generally. This survey involved 87 autistic adults, 159 parents of autistic children and 80 clinical professionals living in New Zealand and Australia. We asked participants questions about themselves and what they thought about early support for young autistic children in general. We then asked participants to rate whether different support goals were appropriate for young autistic children and, if they were appropriate, to rate their level of priority. We found that autistic adults, parents and professionals all rated goals about the adult changing to better support the child, reducing and replacing harmful behaviours and improving the child’s quality of life as the highest priorities. They all rated goals about autism characteristics, play skills and academic skills as the lowest priorities. Compared to parents and/or professionals, autistic adults gave lower priority ratings for play skills, autism characteristics and participation goals. Autistic adults were also more likely to rate goals related to play skills and autism characteristics as inappropriate. While these three participant groups generally agreed on the order of priority of early support goals for young autistic children, autistic adults found goals related to autism characteristics, play and/or participation to be an even lower priority and less appropriate than parents and professionals.
Trauma-informed care (TIC) best practices for improving patient care in the emergency department
Authors: Ashworth Henry , Lewis-O’Connor Annie , Grossman Samara , Brown Taylor , Elisseou Sadie , Stoklosa Hanni 
Published: May 2023

Abstract
A patient’s current or previous experience of trauma may have an impact on their health and affect their ability to engage in health care. Every year, millions of patients who have experienced physically or emotionally traumatic experiences present to emergency departments (ED) for care. Often, the experience of being in the ED itself can exacerbate patient distress and invoke physiological dysregulation. The physiological reactions that lead to fight, flight, or freeze responses can make providing care to these patients complex and can even lead to harmful encounters for providers. There is a need to improve the care provided to the vast number of patients in the ED and create a safer environment for patients and healthcare workers. One solution to this complex challenge is understanding and integrating trauma-informed care (TIC) into emergency services. The federal Substance Abuse and Mental Health Service Administration’s (SAMHSA) six guiding principles of TIC offer a universal precaution framework that ensures quality care for all patients, providers, and staff in EDs. While there is growing evidence that TIC quantitatively and qualitatively improves ED care, there is a lack of practical, emergency medicine-specific guidance on how to best operationalize TIC. In this article, using a case example, we outline how emergency medicine providers can integrate TIC into their practice.
TACE responser NDRG1 acts as a guardian against ferroptosis to drive tumorgenesis and metastasis in HCC
Authors: Tang Bufu , Wang Yajie , Zhu Jinyu , Song Jingjing , Fang Shiji , Weng Qiaoyou , Yang Yang , Tu Jianfei , Zhao Zhongwei , Chen Minjiang , Xu Min , Chen Weiqian , Ji Jiansong 
Published: May 2023

Abstract
Background
The treatment efficacy of transarterial chemoembolization (TACE) for hepatocellular carcinoma (HCC) varies widely between individuals. The aim of this study was to identify subtype landscapes and responser related to TACE, and further clarify the regulatory effect and corresponding mechanism of NDRG1 on HCC tumorgenesis and metastasis.

Methods
The principal component analysis (PCA) algorithm was used to construct a TACE response scoring (TRscore) system. The random forest algorithm was applied to identify the TACE response-related core gene NDRG1 of HCC, and its role in the prognosis of HCC was explored. The role of NDRG1 in the progression and metastasis of HCC and functional mechanism were confirmed using several experimental methods.

Results
Based on the GSE14520 and GSE104580 cohorts, we identified 2 TACE response-related molecular subtypes for HCC with significant differences in clinical features, and the TACE prognosis of Cluster A was significantly better than that of Cluster B (p < 0.0001). We then established the TRscore system and found that the low TRscore group showed a higher probability of survival and a lower rate of recurrence than the high TRscore group (p < 0.05) in both the HCC and TACE-treated HCC cohorts within the GSE14520 cohort. NDRG1 was determined to be the the hub gene associated with the TACE response of HCC and its high expression suggested a poor prognosis. Furthermore, The suppression of NDRG1 konckdown in tumorgenesis and metastasis of HCC was clarified in both vivo and vitro, which was importantly achieved through inducing ferroptosis in HCC cells, especially contributing to RLS3-induced ferroptosis.

Conclusion
The constructed TACE response-related molecular subtypes and TRscores can specifically and accurately predict TACE prognosis for HCC. In addition, the TACE response-related hub gene NDRG1 may act as a guardian against ferroptosis to drive tumorgenesis and metastasis in HCC, which laid a new foundation for the development of new potential targeted therapy strategies to improve disease prognosis in HCC patients.
DePolymerase Predictor (DePP): a machine learning tool for the targeted identification of phage depolymerases
Authors: Magill Damian J. , Skvortsov Timofey A. 
Published: May 2023

AbstractBiofilm production plays a clinically significant role in the pathogenicity of many bacteria, limiting our ability to apply antimicrobial agents and contributing in particular to the pathogenesis of chronic infections. Bacteriophage depolymerases, leveraged by these viruses to circumvent biofilm mediated resistance, represent a potentially powerful weapon in the fight against antibiotic resistant bacteria. Such enzymes are able to degrade the extracellular matrix that is integral to the formation of all biofilms and as such would allow complementary therapies or disinfection procedures to be successfully applied. In this manuscript, we describe the development and application of a machine learning based approach towards the identification of phage depolymerases. We demonstrate that on the basis of a relatively limited number of experimentally proven enzymes and using an amino acid derived feature vector that the development of a powerful model with an accuracy on the order of 90% is possible, showing the value of such approaches in protein functional annotation and the discovery of novel therapeutic agents.
Plant trait networks reveal adaptation strategies in the drylands of China
Authors: Wang Xiaoting , Ji Mingfei , Zhang Yahui , Zhang Liang , Akram Muhammad Adnan , Dong Longwei , Hu Weigang , Xiong Junlan , Sun Ying , Li Hailin , Degen Abraham Allan , Ran Jinzhi , Deng Jianming 
Published: May 2023

Abstract
Background
Plants accomplish multiple functions by the interrelationships between functional traits. Clarifying the complex relationships between plant traits would enable us to better understand how plants employ different strategies to adapt to the environment. Although increasing attention is being paid to plant traits, few studies focused on the adaptation to aridity through the relationship among multiple traits. We established plant trait networks (PTNs) to explore the interdependence of sixteen plant traits across drylands.

Results
Our results revealed significant differences in PTNs among different plant life-forms and different levels of aridity. Trait relationships for woody plants were weaker, but were more modularized than for herbs. Woody plants were more connected in economic traits, whereas herbs were more connected in structural traits to reduce damage caused by drought. Furthermore, the correlations between traits were tighter with higher edge density in semi-arid than in arid regions, suggesting that resource sharing and trait coordination are more advantageous under low drought conditions. Importantly, our results demonstrated that stem phosphorus concentration (SPC) was a hub trait correlated with other traits across drylands.

Conclusions
The results demonstrate that plants exhibited adaptations to the arid environment by adjusting trait modules through alternative strategies. PTNs provide a new insight into understanding the adaptation strategies of plants to drought stress based on the interdependence among plant functional traits.
Molecular insights into the responses of barley to yellow mosaic disease through transcriptome analysis
Authors: Zhang Mengna , Hong Yi , Zhu Juan , Pan Yuhan , Zhou Hui , Lv Chao , Guo Baojian , Wang Feifei , Xu Rugen 
Published: May 2023

Abstract
Background
Barley (Hordeum vulgare L.) represents the fourth most essential cereal crop in the world, vulnerable to barley yellow mosaic virus (BaYMV) and/or barley mild mosaic virus (BaMMV), leading to the significant yield reduction. To gain a better understanding of the mechanisms regarding barley crop tolerance to virus infection, we employed a transcriptome sequencing approach and investigated global gene expression among three barley varieties under both infected and control conditions.

Results
High-throughput sequencing outputs revealed massive genetic responses, reflected by the barley transcriptome after BaYMV and/or BaMMV infection. Significant enrichments in peptidase complex and protein processing in endoplasmic reticulum were clustered through Gene ontology and KEGG analysis. Many genes were identified as transcription factors, antioxidants, disease resistance genes and plant hormones and differentially expressed between infected and uninfected barley varieties. Importantly, general response genes, variety-specific and infection-specific genes were also discovered. Our results provide useful information for future barley breeding to resist BaYMV and BaMMV.

Conclusions
Our study elucidates transcriptomic adaptations in barley response to BaYMV/BaMMV infection through high-throughput sequencing technique. The analysis outcome from GO and KEGG pathways suggests that BaYMV disease induced regulations in multiple molecular-biology processes and signalling pathways. Moreover, critical DEGs involved in defence and stress tolerance mechanisms were displayed. Further functional investigations focusing on these DEGs contributes to understanding the molecular mechanisms of plant response to BaYMV disease infection, thereby offering precious genetic resources for breeding barley varieties resistant to BaYMV disease.
Karyomegalic interstitial nephritis as a rare cause of kidney graft dysfunction: case report and review of literature
Authors: El-Husseiny Moustafa Fatma , Nagy Eman , Elwasif Salwa Mahmoud , Sobh Mohamed 
Published: May 2023

AbstractKaryomegalic interstitial nephritis (KIN) is a rare cause of chronic interstitial nephritis characterized by enlarged renal tubular epithelial nuclei. The first case of KIN reported in a kidney graft was in 2019. Here, we report the first case of KIN in 2 brothers receiving kidneys from 2 different unrelated living donors. A male kidney transplant recipient with focal segmental glomerulosclerosis as the original kidney disease presented with graft impairment and proteinuria, and graft biopsy revealed KIN. This patient had a brother who was also a kidney transplant recipient and had one episode of graft impairment and was diagnosed with KIN as well.
Exploring trends of severe postpartum haemorrhage: a hospital-based study
Authors: Pettersen Silje , Falk Ragnhild Sørum , Vangen Siri , Nyfløt Lill Trine 
Published: May 2023

Abstract
Background
Over the past two decades several high-income countries have reported increased rates of postpartum haemorrhage (PPH). Many of the studies are registry studies with limited access to detailed information. We aimed to explore trends of severe PPH in the largest labour ward in Norway during a 10-year period with a hospital based study. Our population constituted all women who gave birth after week 22 at Oslo University Hospital between 2008 and 2017. The main outcome measure was severe PPH, defined as registered blood loss greater than 1500 ml, or transfusion of blood products due to PPH.

Methods
We estimated the incidence of severe PPH and blood transfusions, and performed temporal trend analysis. We performed Poisson regression analysis to investigate associations between pregnancy characteristics and severe PPH, presented using crude incidence rate ratios (IRR) with 95% confidence intervals (CI)s. We also estimated annual percentage change of the linear trends.

Results
Among 96 313 deliveries during the 10-year study period, 2621 (2.7%) were diagnosed with severe PPH. The incidence rate doubled from 17.1/1000 to 2008 to 34.2/1000 in 2017. We also observed an increased rate of women receiving blood transfusion due to PPH, from 12.2/1000 to 2008 to 27.5/1000 in 2017. The rates of invasive procedures to manage severe PPH did not increase, and we did not observe a significant increase in the number of women defined with maternal near miss or massive transfusions. No women died due to PPH during the study period.

Conclusion
We found a significant increasing trend of severe PPH and related blood transfusions during the 10-year study period. We did not find an increase in massive PPH, or in invasive management, and we suspect that the rise can be at least partly explained by increased awareness and early intervention contributing to improved registration of severe PPH.