bluuebunny/crossref_metadata_2025_split huggingface dataset:
CAP and LSM as determined by VCTE are independent predictors of all-cause mortality in the US adult population
Authors: Vilar-Gomez Eduardo , Vuppalanchi Raj , Gawrieh Samer , Samala Niharika , Chalasani Naga 
Published: January 2023

Background and Aim:
Data retrospective cohort studies have shown that liver stiffness measurement (LSM) by transient elastography (TE, FibroScan) can predict mortality in patients with NAFLD, however, its ability to predict mortality at a population level is unknown. We investigated the ability of LSM and controlled-attenuation parameter (CAP) by TE to predict mortality in a prospective US cohort.

Approach and Results:
A total of 4192 US adults aged ≥18 years enrolled in the National Health, and Nutrition Examination Survey (NHANES) (2017–2018) with reliable information on CAP and LSM by TE were included in this analysis. All-specific and cause-specific mortality were ascertained by linkage to National Death Index records through December 31, 2019. Cox models were used to estimate HR and 95% CI. During a mean follow-up of 24.4 months, there were 68 deaths (1.6%). CAP (adjusted HR: 1.01, 95% CI: 1.0–1.05), and LSM (adjusted HR: 1.06, 95% CI: 1.02–1.11) were independently associated with overall mortality. NAFLD by CAP ≥285 had a 2.2-fold (95% CI: 1.0–4.7) increased odds of mortality compared with non-NAFLD. Cumulative mortality rates were significantly higher in participants with LSM of 9.7–13.5 (advanced fibrosis) and LSM ≥13.6 (cirrhosis) as compared with LSM <9.7; p value for trend across groups <0.01. LSM ≥13.6 displayed the highest mortality risk (adjusted HR: 3.2, 95% CI: 1.3–7.8). Compared with LSM <10 [absence of advanced chronic liver disease (ACLD)], LSM 10–19.9 (likely ACLD), and ≥20 kPa (likely ACLD with clinically significant portal hypertension) conferred a 3.4-fold (95% CI: 1.0–13.8) and 5.2-fold (95% CI: 1.2–22.3) increase in hazards of mortality.

Conclusions:
Our study findings highlight the importance of liver health as a predictor of overall mortality at a population level.
Liver-restricted deletion of the biliary atresia candidate gene Pkd1l1 causes bile duct dysmorphogenesis and ciliopathy
Authors: Hellen Dominick J. , Bennett Ashley , Malla Sudarshan , Klindt Caroline , Rao Anuradha , Dawson Paul A. , Karpen Saul J. 
Published: January 2023

Background and Aims:
A recent multicenter genetic exploration of the biliary atresia splenic malformation syndrome identified mutations in the ciliary gene PKD1L1 as candidate etiologic contributors. We hypothesized that deletion of Pkd1l1 in developing hepatoblasts would lead to cholangiopathy in mice.

Approach and Results:
CRISPR-based genome editing inserted loxP sites flanking exon 8 of the murine Pkd1l1 gene. Pkd1l1

Fl/Fl
cross-bred with alpha-fetoprotein-Cre expressing mice to generate a liver-specific intrahepatic Pkd1l1-deficient model (LKO). From embryonic day 18 through week 30, control (Fl/Fl) and LKO mice were evaluated with standard serum chemistries and liver histology. At select ages, tissues were analyzed using RNA sequencing, immunofluorescence, and electron microscopy with a focus on biliary structures, peribiliary inflammation, and fibrosis. Bile duct ligation for 5 days of Fl/Fl and LKO mice was followed by standard serum and liver analytics. Histological analyses from perinatal ages revealed delayed biliary maturation and reduced primary cilia, with progressive cholangiocyte proliferation, peribiliary fibroinflammation, and arterial hypertrophy evident in 7- to 16-week-old LKO versus Fl/Fl livers. Following bile duct ligation, cholangiocyte proliferation, peribiliary fibroinflammation, and necrosis were increased in LKO compared with Fl/Fl livers.

Conclusions:
Bile duct ligation of the Pkd1l1-deficient mouse model mirrors several aspects of the intrahepatic pathophysiology of biliary atresia in humans including bile duct dysmorphogenesis, peribiliary fibroinflammation, hepatic arteriopathy, and ciliopathy. This first genetically linked model of biliary atresia, the Pkd1l1 LKO mouse, may allow researchers a means to develop a deeper understanding of the pathophysiology of this serious and perplexing disorder, including the opportunity to identify rational therapeutic targets.
Improving Outcomes for Bronchiolitis Patients After Implementing a High-Flow Nasal Cannula Holiday and Standardizing Discharge Criteria in a PICU
Authors: Maue Danielle K. , Ealy Aimee , Hobson Michael J. , Peterson Rachel J. , Pike Francis , Nitu Mara E. , Tori Alvaro J. , Abu-Sultaneh Samer 
Published: January 2023

OBJECTIVES:
To decrease length of high-flow nasal cannula (HFNC), PICU, and hospital length of stay (LOS).

DESIGN:
Quality improvement project.

SETTING:
A quaternary academic PICU.

PATIENTS:
Patients with bronchiolitis less than 24 months old.

INTERVENTIONS:
After initial implementation of a respiratory therapist (RT)-driven HFNC protocol (Plan-Do-Study-Act [PDSA] 1) in October 2017, additional interventions included adjusting HFNC wean rate (PDSA 2) in July 2020, a HFNC holiday (PDSA 3), and standardized discharge criteria (PDSA 4) in October 2021.

MEASUREMENTS AND MAIN RESULTS:
Duration of HFNC was used as the primary outcome measure. PICU LOS and hospital LOS were used as secondary outcome measures. Noninvasive ventilation use, invasive mechanical ventilation use, and 7-day PICU and hospital readmission rates were used as balancing measures. A total of 1,310 patients were included in this study. Patients in PDSA 2, PDSA 3 and 4 groups were older compared with pre-intervention and PDSA 1 (median of 9 and 10 mo compared with 8 mo; p = 0.01). HFNC duration decreased from 2.5 to 1.8 days after PDSA 1, then to 1.3 days after PDSA 2. PICU LOS decreased from 2.6 to 2.1 days after PDSA 1, 1.8 days after PDSA 2, and 1.5 days after PDSA 3 and 4. Hospital LOS decreased from 5.7 to 4.5 days after PDSA 1, 3.1 days after PDSA 2, and 2.7 days after PDSA 3 and 4. The use of noninvasive ventilation and invasive mechanical ventilation decreased throughout the study from 23.2% in the pre-intervention group, to 6.9% at the end of the project. The 7-day PICU and hospital readmission rates did not increase after implementation. The percentage of patients discharged from the PICU increased from 6.2% to 21.5%.

CONCLUSIONS:
Modifications to an existing RT-driven HFNC protocol and standardization of discharge criteria led to an improvement in outcomes for patients admitted to the PICU with bronchiolitis without an increase in adverse events.
Growth increases but regeneration declines in response to warming and drying at Arctic treeline in white spruce (Picea glauca)
Authors: Jensen Johanna , Boelman Natalie , Eitel Jan , Vierling Lee , Maguire Andrew , Oelkers Rose , Silva Carlos , Andreu-Hayles Laia , D’Arrigo Rosanne , Griffin Kevin L. 
Published: January 2023

1.AbstractAs a temperature-delineated boundary, the Arctic treeline is predicted to shift northward in response to warming. However, the evidence for northward movement is mixed, with some sections of the treeline advancing while others remain stationary or even retreat. To identify the drivers of this variation, we need a landscape-level understanding of the interactions occurring between climate, tree growth, and population regeneration. In this study, we assessed regeneration alongside annual tree growth and climate during the 20th century. We used an ageheight model combined with tree height from aerial lidar to predict the age structure of 38,652 white spruce trees across 250 ha of Arctic treeline in the central Brooks Range, Alaska, USA. We then used age structure analysis to interpret the trends in regeneration and tree-ring analysis to interpret changes in annual tree growth. The climate became significantly warmer and drier circa 1975, coinciding with divergent responses of regeneration and tree growth. After 1975, regeneration of saplings (trees ≤ 2m tall) decreased compared to previous decades whereas annual growth in mature trees (trees >2m tall) increased by 54% (p<0.0001, Wilcoxon test). Tree-ring width was positively correlated with May-August temperature (p<0.01, Pearson coefficient) during the 20th century. However, after circa 1950, the positive correlation between temperature and growth weakened (i.e., temperature divergence) while the positive correlation with July precipitation strengthened (p<0.01, Pearson coefficient), suggesting that continued drying may limit future growth at this section of Arctic treeline. We conclude that while warmer temperatures appear to benefit annual growth in mature trees, the warmer and drier environmental conditions in spring and summer inhibit regeneration and therefore may be inhibiting the northward advance at this Arctic treeline site. Researchers should consider the interactions between temperature, water availability, and tree age when examining the future of treeline and boreal forest in a changing climate.
A new gene finding tool GeneMark-ETP significantly improves the accuracy of automatic annotation of large eukaryotic genomes
Authors: Bruna Tomas , Lomsadze Alexandre , Borodovsky Mark 
Published: January 2023

AbstractLarge-scale genomic initiatives, such as the Earth BioGenome Project, require efficient methods for eukaryotic genome annotation. Here we present an automatic gene finder, GeneMark-ETP, integrating genomic-, transcriptomic- and protein-derived evidence that has been developed with a focus on large plant and animal genomes. GeneMark-ETP first identifies genomic loci where extrinsic data is sufficient for making gene predictions with ‘high confidence’. The genes situated in the genomic space between the high confidence genes are predicted in the next stage. The set of high confidence genes serves as an initial training set for the statistical model. Further on, the model parameters are iteratively updated in the rounds of gene prediction and parameter re-estimation. Upon reaching convergence, GeneMark-ETP makes the final predictions and delivers the whole complement of predicted genes. GeneMark-ETP outperformed gene finders using a single type of extrinsic evidence. Comparisons with gene finders utilizing both transcript- and protein-derived extrinsic evidence, MAKER2, and TSEBRA, demonstrated that GeneMark-ETP delivered state-of-the-art gene prediction accuracy with the margin of outperforming existing approaches increasing in its applications to larger and more complex eukaryotic genomes.
An analysis of the positive effect of real earnings management on financial performance
Authors: Lim Hyoung Joo , Mali Dafydd 
Published: January 2023

PurposeREM models infer abnormal levels of cashflow from operations (AbCFO), selling, general and admin (AbSGA) and production expenses (AbProd) are opportunistic, based on the supposition that engaging in real activities to meet current earnings targets (t) will negatively influence future performance (t+1). However, from a firm productivity perspective, cost reduction (via AbCFO, AbProd and AbSGA) is interpreted as an efficiency enhancing business strategy. This study therefore differentiates between (1) firms with ineffective management that have engaged in AbCFO, AbProd and AbSGA to achieve an optimal resource-cost mix to generate sales (REMF) and (2) firms with effective management that have not (OEF).Design/methodology/approachUsing a sample of Korean listed firms over the 2000–2016 sample period, the study utilizes data envelopment analysis to capture the capability of management to generate sales from resources that are directly under their control. The study then compares the incremental effect that managerial decision making can have on real earnings management (REM) and future firm performance (period t+1 to t+5).FindingsThe study makes two important contributions. First, consistent with the efficiency/productivity literature, but contrary to seminal REM studies, empirical results shows that AbCFO, AbProd and AbSGA improve firm performance in period t and t+1 (to t+5), demonstrating “REM” is not opportunistic by default. Second, OEF have higher financial performance compared to REMF, in periods t and t+1.Originality/valueThe study therefore invokes resource-based theory and data envelopment analysis to integrate managerial effectiveness (human capital) into REM modelling. The study therefore extends the basic REM residual model.
The influence of complexity, chance and change on the career crafting strategies of SIEs
Authors: Suarez-Bilbao Blanca , Andresen Maike , Crowley-Henry Marian , O'Connor Edward P. 
Published: January 2023

PurposeExternalities influence the career trajectories of self-initiated expatriates (SIEs) and their respective career crafting. This study aims to explore the international career crafting of SIEs (encompassing their proactive career reflection and construction), taking the combined external influences of complexity, chance and change into consideration.Design/methodology/approachThe authors employ a qualitative (interpretative) approach, combining career crafting and the chaos theory of careers (CTC) to further understand, from an individual standpoint, the impact of externalities on the career crafting strategies of 24 SIEs who have relocated within the European Union.FindingsThe authors show that SIEs' proactively craft their careers to varying degrees and with varying frequency. The CTC – incorporating complexity, chance and change – allows for a more nuanced understanding of SIEs' career crafting.Originality/valueThis paper applies the concept of career crafting to an international context, exploring the impact of externalities on SIEs' careers. In this way, the authors combine two previously separate theories, extend the application of career crafting to an international career context and emphasise the role of temporality and the whole-life view of career in SIEs’ career crafting approach.
When are trans women treated worse than trans men?
Authors: Rudin Joel , Billing Tejinder , Farro Andrea , Yang Yang 
Published: January 2023

PurposeThis paper aims to test penis panic theory, which predicts that trans women will face more discrimination than trans men in some but not all situations.Design/methodology/approachRespondents were 262 American college students who were all enrolled in the same undergraduate course. They were presented with a case about coworker resistance to transgender employees' use of the workplace restrooms of their choice. Four versions of a case were randomly distributed as follows: trans woman, restroom with one toilet; trans woman, restroom with three toilets; trans man, restroom with one toilet and trans man, restroom with three toilets.FindingsThe authors observed greater discrimination against trans women compared to trans men when there was one toilet but not when there were three toilets. This supports penis panic theory.Research limitations/implicationsThe chief limitation was the use of American college students as respondents. The results may not generalize to practicing managers especially in other countries. Future researchers should develop a scale to measure situational discrimination against trans women. This study should be replicated in other contexts to deepen the understanding of discrimination against trans men and trans women with disabilities, as well as discrimination against nonbinary individuals who identify as neither trans men nor trans women.Practical implicationsEmployers need to search for situations in which trans women face greater discrimination than trans men, because they can be resolved in ways that protect the rights of transgender employees no matter how transphobic their coworkers may be. Also, employers need a nuanced approach to combat discrimination that recognizes the unique perspectives of trans men, trans women and other members of the transgender community.Originality/valueThis is the first quantitative study of penis panic theory, and it illuminates the understanding of discrimination against transgender individuals.
Front- and back-end employee satisfaction during service transition
Authors: Karatzas Antonios , Papadopoulos Georgios , Stamolampros Panagiotis , Raja Jawwad Z. , Korfiatis Nikolaos 
Published: January 2023

PurposeScholars studying servitization argue that manufacturers moving into services need to develop new job roles or modify existing ones, which must be enacted by employees with the right mentality, skill sets, attitudes and capabilities. However, there is a paucity of empirical research on how such changes affect employee-level outcomes.Design/methodology/approachThe authors theorize that job enrichment and role stress act as countervailing forces during the manufacturer's service transition, with implications for employee satisfaction. The authors test the hypotheses using a sample of 21,869 employees from 201 American manufacturers that declared revenues from services over a 10-year period.FindingsThe authors find an inverted U-shaped relationship between the firm's level of service infusion and individual employee satisfaction, which is flatter for front-end staff. This relationship differs in shape and/or magnitude between firms, highlighting the role of unobserved firm-level idiosyncratic factors.Practical implicationsServitized manufacturers, especially those in the later stage of their transition (i.e. when services start to account for more than 50% of annual revenues), should try to ameliorate their employees' role-induced stress to counter a drop in satisfaction.Originality/valueThis is one of the first studies to examine systematically the relationship between servitization and individual employee satisfaction. It shows that back-end employees in manufacturing firms are considerably affected by an increasing emphasis on services, while past literature has almost exclusively been concerned with front-end staff.
Economic–statistical design of Bayesian X‾ control chart based on the predictive distribution
Authors: Seirani Razieh , Torabian Mohsen , Behzadi Mohammad Hassan , Seif Asghar 
Published: January 2023

PurposeThe purpose of this paper is to present an economic–statistical design (ESD) for the Bayesian X‾ control chart based on predictive distribution with two types of informative and noninformative prior distributions.Design/methodology/approachThe design used in this study is based on determining the control chart of the predictive distribution and then its ESD. The new proposed cost model is presented by considering the conjugate and Jeffrey's prior distribution in calculating the expected total cycle time and expected cost per cycle, and finally, the optimal design parameters and related costs are compared with the fixed ratio sampling (FRS) mode.FindingsNumerical results show decreases in costs in this Bayesian approach with both Jeffrey's and conjugate prior distribution compared to the FRS mode. This result shows that the Bayesian approach which is based on predictive density works better than the classical approach. Also, for the Bayesian approach, however, there is no significant difference between the results of using Jeffrey's and conjugate prior distributions. Using sensitivity analysis, the effect of cost parameters and shock model parameters and deviation from the mean on the optimal values of design parameters and related costs have been investigated and discussed.Practical implicationsThis research adds to the body of knowledge related to quality control of process monitoring systems. This paper may be of particular interest to quality system practitioners for whom the effect of the prior distribution of parameters on the quality characteristic distribution is important.Originality/valueeconomic statistical design (ESD) of Bayesian control charts based on predictive distribution is presented for the first time.
Case study reflections of an internet child abuse material offender informing the development of a proposed assessment instrument
Authors: Garrington Catherine , Kelty Sally , Rickwood Debra , Boer Douglas Pieter 
Published: January 2023

Purpose
Internet child abuse material (I/CAM) offences negatively affect children in our own communities and in the wider virtual world. This study aims to understand the differentiation between online (internet) and offline (contact) offenders. The development of the Estimated Risk for Internet Child Sexual Offending (ERICSO), a proposed instrument for I/CAM offenders, incorporated a case study component to test on a known offender before the tool is applied to a wider sample.

Design/methodology/approach
The case study approach provides a unique opportunity for researchers to consider reflections from an I/CAM offender. These insights provide unique perspectives on areas for further exploration, including suggestions for consideration in the assessment and treatment of I/CAM offenders.

Findings
Mr A is a male convicted of possessing I/CAM with previous convictions for contact child sexual offending. During the development of the ERICSO, Mr A provided commentary on proposed questions based on his experiences as an offender and his communications with other offenders. Mr A’s feedback was generally consistent with current research findings, with notable suggestions in recognising the importance of differentiating between fantasy/reality, violence/voyeurism and the role technology plays in I/CAM offences. These reflections will be considered in conjunction with ongoing development and validity studies of the ERICSO to contribute to the targeted assessment and risk-relevant treatment for I/CAM offenders.

Originality/value
The use of a case study in the development of a proposed assessment instrument provides a unique perspective to improve ecological validity.
Can behaviour and physiology mitigate effects of warming on ectotherms? A test in urban ants
Authors: Youngsteadt Elsa , Prado Sara Guiti , Keleher Kirsten Joanna , Kirchner Michelle 
Published: January 2023

Abstract

Global climate change is expected to have pervasive effects on the diversity and distribution of species, particularly ectotherms whose body temperatures depend on environmental temperatures. However, these impacts remain difficult to predict, in part because ectotherms may adapt or acclimate to novel conditions or may use behavioural thermoregulation to reduce their exposure to stressful microclimates.

Here we examine the potential for physiological and behavioural changes to mitigate effects of environmental warming on five species of ants in a temperate forest habitat subject to urban warming.

We worked in eight urban and eight non‐urban forest sites in North Carolina, USA; sites experienced a 1.1°C range of mean summer air temperatures. At each site, we documented species‐specific microclimates (ant operative temperatures, Te) and ant activity on a transect of 14 bait stations at three times of day. In the laboratory, we measured upper thermal tolerance (CTmax) and thermal preference (Tpref) for each focal species. We then asked whether thermal traits shifted at hotter sites, and whether ants avoided non‐preferred microclimates in the field.

CTmax and Tpref did not increase at warmer sites, indicating that these populations did not adapt or acclimate to urban warming. Consistent with behavioural thermoregulation, four of the five species were less likely to occupy baits where Te departed from Tpref. Apparent thermoregulation resulted from fixed diel activity patterns that helped ants avoid the most inappropriate temperatures but did not compensate for daily or spatial temperature variation: Hotter sites had hotter ants.

This study uses a novel approach to detect behavioural thermoregulation and sublethal warming in foraging insects. The results suggest that adaptation and behaviour may not protect common temperate forest ants from a warming climate, and highlight the need to evaluate effects of chronic, sublethal warming on small ectotherms.