bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perilaku Bidan dalam Penggunaan APD pada APN di Wilayah Kerja Ranting Ibi Pedes Kabupaten Karawang Tahun 2022
Authors: Sari Nina Yuliana , Halimatusyadiah Leni , Octavia Rina 
Published: July 2023

The aim of the study was to determine the behavior analysis of midwives in using personal protective equipment in normal delivery care in the 2022 IBI Pedes Karawang Working Area. This study used an analytical method with a cross sectional design. A sample of 54 midwives was taken using the total sampling method and the research instrument used a questionnaire. Bivariate analysis used the chi square test with a value of p = ? 0.05. The results of the study stated that respondents whose behavior was 37% obedient, had good knowledge 44.4%, good attitude 44.4%, availability of complete tools 46.3%. The results of the bivariate analysis showed that there was a relationship between knowledge and behavior in using PPE (p=0.01), there was a relationship between attitude and behavior in using PPE (p=0.001), there was a relationship between the availability of tools and behavior in using PPE (p=0.001). Based on the results of the research, it is hoped that the IBI Pedes Branch can provide books, posters and provide guidance for midwives. It is hoped that all midwives can use the complete PPE.

Tujuan penelitian untuk mengetahui Analisis perilaku bidan dalam penggunaan alat pelindung diri pada asuhan persalinan normal di Wilayah Kerja Ranting IBI Pedes Karawang 2022. Penelitian ini menggunakan metode Analitik dengan rancangan Cross Sectional. Jumlah sempel 54 orang bidan diambil dengan metoda total sampling dan instrument penelitian ini menggunakan kuesioner. Analisis bivariat menggunakan uji chi square dengan nilai p = ? 0,05. Hasil penelitian menyatakan bahwa responden yang Perilaku patuh 37%, pengetahuan nya baik 44,4%, sikap baik, 44,4%, ketersediaan alat yg lengkap 46,3%. Hasil analisis bivariat menunjukan ada hubungan antara pengetahuan dengan perilaku penggunaan APD (p=0,01), ada hubungan antara sikap dengan perilaku penggunaan APD (p=0,001), ada hubungan antara ketersediaan alat dengan perilaku penggunaan APD (p=0,001). Berdasarkan hasil penelitian diharapkan Ranting IBI Pedes dapat menyediakan buku-buku, poster serta mengadakan pembinaan bagi bidan, harapannya semua bidan dapat menggunakan APD secara lengkap.
Nitrogen‐Rich Rigid Polybenzimidazole With Phosphoric Acid Shows Promising Electrochemical Activity and Stability for High‐Temperature Proton Exchange Membrane Fuel Cells
Authors: Gao Aolei , Wang Wenwen , Wang Peng , Wu Hongchao , Gong Chenliang , Wu Aogui , Wei Gongyi , Wang Lei 
Published: July 2023

AbstractPolybenzimidazoles (PBIs) are the most promising binders for the catalyst layer (CL) in high‐temperature proton exchange membrane fuel cells (HT‐PEMFC). However, traditional commercial PBIs are not applied in binders because they do not enhance the electrochemical performance and because the related solvents are not environmentally friendly. In addition, proton transfer channels in PBIs are not investigated at the microscopic and atomic scales to date. In this study, a nitrogen‐rich rigid PBI binder containing pyridine, diazofluorene, and partially grafted nitrile (PBPBI‐3CN) is prepared with a functionalized structure, good thermal stability, and good solubility in an environmentally friendly solvent. A membrane electrode assembly (MEA) is fabricated with the PBPBI‐3CN binder, providing a high peak power density, low resistance, and good stability. The protonation, hydrogen bond networks, and platform for proton transfer are confirmed in the CLs. The protonation of PBPBI‐3CN occurs in two steps. First, some phosphoric acid (PA) molecules bind to nitrogen‐containing acidophilic groups via preliminary protonation; second, multiple PA molecules then interact with nitrogen‐containing acidophilic groups via further protonation. With protonation as the foundation, a sufficient amount of PA molecules form a hydrogen bond network, and proton transfer channels are established.
From Volumetric to Planar Multiplexing: Phase‐Coded Metasurfaces without the Bragg Effect
Authors: Chen Jia , Wang Dapeng , Si Guangyuan , Zhang Rongxin , Hwang Yongsop , Wang Xinjian , Zheng Jiaxin , Shen Mengzhe , Wang Qian , Lin Jiao 
Published: July 2023

AbstractMetasurfaces consisting of planar subwavelength structures with minimal thickness are appealing to emerging technologies such as integrated optics and photonic chips for their small footprint and compatibility with sophisticated planar nanofabrication techniques. However, reduced dimensionality due to the 2D nature of a metasurface poses challenges to the adaptation of a few useful methods that have found great success with conventional optics in 3D space. For instance, Bragg diffraction is the foundation of the well‐established technique of phase‐coded multiplexing in volume holography. It relies on interference among the scattered waves from multiple layers across the thickness of a sample. In this work, despite losing the dimension in thickness, a metasurface is devised to experimentally demonstrate phase‐coded multiplexing by replacing free‐space light with a surface wave in its output. The in‐plane interference along the propagation of the surface wave resembles the Bragg diffraction, thus enabling phase‐coded multiplexing in the 2D design. An example of code‐based all‐optical routing is also achieved by using a multiplexed metasurface, which can find applications in photonic data processing and communications.
A Triphenylphosphine‐Based Microporous Polymer for a Wittig Reaction Cycle in the Solid State
Authors: Weigelt Vincent , Vogl Sarah , Schmidt Johannes , Thomas Arne 
Published: July 2023

AbstractThe Wittig reaction is a key step in industrial processes to synthesise large quantities of vitamin A and various other important chemicals that are used in daily life. This article presents a pathway to achieve the Wittig reaction in a solid network. A highly porous triphenylphosphine‐based polymer was applied as a solid Wittig reagent that undergoes, in a multi‐step cycle, in total six post‐synthetic modifications. This allowed for regeneration of the solid Wittig reagent and reuse for the same reaction cycle. Of particular industrial relevance is that the newly developed material also enables a simple way of separating the product by filtration. Therefore, additional costly and difficult separation and purification steps are no longer needed.
The Keto‐Switched Photocatalysis of Reconstructed Covalent Organic Frameworks for Efficient Hydrogen Evolution
Authors: Wu Shuhong , Li Chao , Wang Ying , Zhuang Yan , Pan Yi , Wen Na , Wang Shuo , Zhang Zizhong , Ding Zhenxin , Yuan Rusheng , Dai Wenxin , Fu Xianzhi , Long Jinlin 
Published: July 2023

AbstractThe keto‐switched photocatalysis of covalent organic frameworks (COFs) for efficient H2 evolution was reported for the first time by engineering, at a molecular level, the local structure and component of the skeletal building blocks. A series of imine‐linked BT‐COFs were synthesized by the Schiff‐base reaction of 1, 3, 5‐benzenetrialdehyde with diamines to demonstrate the structural reconstruction of enol to keto configurations by alkaline catalysis. The keto groups of the skeletal building blocks served as active injectors, where hot π‐electrons were provided to Pt nanoparticles (NPs) across a polyvinylpyrrolidone (PVP) insulting layer. The characterization results, together with density functional theory calculations, indicated clearly that the formation of keto‐injectors not only made the conduction band level more negative, but also led to an inhomogeneous charge distribution in the donor‐acceptor molecular building blocks to form a strong intramolecular built‐in electric field. As a result, visible‐light photocatalysis of TP‐COFs‐1 with one keto group in the skeletal building blocks was successfully enabled and achieved an impressive H2 evolution rate as high as 0.96 mmol g−1 h−1. Also, the photocatalytic H2 evolution rates of the reconstructed BT‐COFs‐2 and ‐3 with two and three keto‐injectors were significantly enhanced by alkaline post‐treatment.
Hydrogen online monitoring based on thermal conductivity for anaerobic microorganisms
Authors: Miebach Katharina , Finger Maurice , Scherer Alexandra Maria Katarina , Maaß Constantin Alexander , Büchs Jochen 
Published: July 2023

AbstractH2‐producing microorganisms are a promising source of sustainable biohydrogen. However, most H2‐producing microorganisms are anaerobes, which are difficult to cultivate and characterize. While several methods for measuring H2 exist, common H2 sensors often require oxygen, making them unsuitable for anaerobic processes. Other sensors can often not be operated at high gas humidity. Thus, we applied thermal conductivity (TC) sensors and developed a parallelized, online H2 monitoring for time‐efficient characterization of H2 production by anaerobes. Since TC sensors are nonspecific for H2, the cross‐sensitivity of the sensors was evaluated regarding temperature, gas humidity, and CO2 concentrations. The systems' measurement range was validated with two anaerobes: a high H2‐producer (Clostridium pasteurianum) and a low H2‐producer (Phocaeicola vulgatus). Online monitoring of H2 production in shake flask cultivations was demonstrated, and H2 transfer rates were derived. Combined with online CO2 and pressure measurements, molar gas balances of the cultivations were closed, and an anaerobic respiration quotient was calculated. Thus, insight into the effect of medium components and inhibitory cultivation conditions on H2 production with the model anaerobes was gained. The presented online H2 monitoring method can accelerate the characterization of anaerobes for biohydrogen production and reveal metabolic changes without expensive equipment and offline analysis.
A retrospective real‐world experience of immunotherapy in patients with extensive stage small‐cell lung cancer
Authors: Qiu Guihuan , Wang Fei , Xie Xiaohong , Liu Ting , Zeng Chen , Chen Ziyao , Zhou Maolin , Deng Haiyi , Yang Yilin , Lin Xinqing , Xie Zhanhong , Sun Gengyun , Zhou Chengzhi , Liu Ming 
Published: July 2023

AbstractBackgroundThe treatment of extensive stage small‐cell lung cancer (ES‐SCLC) has only made modest progress in the past decade, with two immune checkpoint inhibitors (ICIs), atezolizumab and durvalumab, approved for the treatment of SCLC by January 2022. However, currently, there is limited real‐world data on ES‐SCLC patients received immunotherapy.MethodsWe retrospectively collected and analyzed the demographic and treatment data of ES‐SCLC patients at the First Affiliated Hospital of Guangzhou Medical University from January 2017 to January 2022. Survival and prognosis information was obtained through follow‐up.ResultsA total of 353 ES‐SCLC patients were included, of which 165 received immunotherapy combined with chemotherapy as the first‐line (FL) treatment (chemo‐immune group), and 188 received chemotherapy (chemotherapy group). The objective response rate (ORR) and disease control rate (DCR) of patients receiving immunotherapy as the FL treatment were better than the chemotherapy group (76.97% vs. 48.40%, p < 0.001, and 83.03% vs. 68.09%, p < 0.001). Moreover, the progression‐free survival (PFS) and overall survival (OS) of ES‐SCLC patients receiving immunotherapy as the FL treatment were better than the chemotherapy group (6.7 months vs. 5.1 months, p < 0.001, and 12.5 months vs. 11.2 months, p < 0.001). Furthermore, the OS of ES‐SCLC patients who received immunotherapy as second‐line treatment was better than that in the chemotherapy group (15.9 months vs. 12.9 months, p = 0.036).ConclusionICIs combined with chemotherapy as the FL treatment could be beneficial to the ORR, DCR, PFS, and OS of ES‐SCLC patients. Furthermore, ES‐SCLC patients can benefit from ICIs in the second‐line treatment, even if they had not received ICIs in the FL treatment.
Preparation of Dual‐activity Enzyme‐metal‐nanoparticles Conjugate Catalysts for Cascade Processes
Authors: Palomo Jose M. 
Published: July 2023

AbstractThe fabrication of novel systems where enzymatic and metallic actives sites directly interact represents an elegant strategy for sustainable processes. One of the new strategies involves the in situ formation of metal nanoparticles on a protein network as scaffold. This biological entity is the key element because it conserves the biological catalytic efficiency and induces the final metallic nanoparticles generation on the structure. This method allows to obtain bifunctional enzyme‐metallic catalysts with excellent versatility and efficiency in a different reaction and experimental conditions. In this concept article, the relevant aspects in terms of fabrication of enzyme‐metal nanoparticles hybrids and recently reported examples of successful application in cascade processes will be described.
The Rise of Structurally Anisotropic Plasmonic Janus Gold Nanostars
Authors: Singh Prem , Kundu Koustav , Seçkin Sezer , Bhardwaj Keshav , König Tobias A. F. , Jaiswal Amit 
Published: July 2023

AbstractNanostructures intrinsically possessing two different structural or functional features, often called Janus nanoparticles, are emerging as a potential material for sensing, catalysis, and biomedical applications. Herein, we report the synthesis of plasmonic gold Janus nanostars (NSs) possessing a smooth concave pentagonal morphology with sharp tips and edges on one side and, contrastingly, a crumbled morphology on the other. The methodology reported herein for their synthesis – a single‐step growth reaction – is different from any other Janus nanoparticle preparation involving either template‐assisted growth or a masking technique. Interestingly, the coexistence of lower‐ and higher‐index facets was found in these Janus NSs. The general paradigm for synthesizing gold Janus NSs was investigated by understanding the kinetic control mechanism with the combinatorial effect of all the reagents responsible for the structure. The optical properties of the Janus NSs were realized by corelating their extinction spectra with the simulated data. The size‐dependent surface‐enhanced Raman scattering (SERS) activity of these Janus NSs was studied with 1,4‐BDT as the model analyte. Finite‐difference time‐domain simulations for differently sized particles revealed the distribution of electromagnetic hot‐spots over the particles resulting in enhancement of the SERS signal in a size‐dependent manner.
Asymmetric Transfer Hydrogenation as a Key Step in the Synthesis of the Phosphonic Acid Analogs of Aminocarboxylic Acids
Authors: Dinhof Tamara , Kalina Thomas , Stanković Toda , Braunsteiner Kristóf , Rohrbach Philipp , Turhan Ertan , Gradwohl Andreas , Königshofer Artur , Horak Jeannie , Pallitsch Katharina 
Published: July 2023

Abstractα‐Aminophosphonic acids have a remarkably broad bioactivity spectrum. They can function as highly efficient transition state mimics for a variety of hydrolytic and angiotensin‐converting enzymes, which makes them interesting target structures for synthetic chemists. In particular, the phosphonic acid analogs to α‐aminocarboxylic acids (PaAAs) are potent enzyme inhibitors, but many of them are only available by chiral or enzymatic resolution; sometimes only one enantiomer is accessible, and several have never been prepared in enantiopure form at all. Today, a variety of methods to access enantiopure α‐aminophosphonic acids is known but none of the reported approaches can be generally applied for the synthesis of PaAAs. Here we show that the phosphonic acid analogs of many (proteinogenic) α‐amino acids become accessible by the catalytic, stereoselective asymmetric transfer hydrogenation (ATH) of α‐oxo‐phosphonates. The highly enantioenriched (enantiomeric excess (ee) ≥ 98 %) α‐hydroxyphosphonates obtained are important pharmaceutical building blocks in themselves and could be easily converted to α‐aminophosphonic acids in most studied cases. Even stereoselectively deuterated analogs became easily accessible from the same α‐oxo‐phosphonates using deuterated formic acid (DCO2H).
Deep Eutectic Solvents: An Eco‐friendly Design for Drug Engineering
Authors: Oyoun Feras , Toncheva Antoniya , Henríquez Luis Castillo , Grougnet Raphael , Laoutid Fouad , Mignet Nathalie , Alhareth Khair , Corvis Yohann 
Published: July 2023

AbstractIn the spirit of circular economy and sustainable chemistry, the use of environmentally friendly chemical products in pharmacy has become a hot topic. In recent years, organic solvents have been the subject of a great range of restriction policies due to their harmful effects on the environment and toxicity to human health. In parallel, deep eutectic solvents (DESs) have emerged as suitable greener solvents with beneficial environmental impacts and a rich palette of physicochemical advantages related to their low cost and biocompatibility. Additionally, DESs can enable remarkable solubilizing effect for several active pharmaceutical ingredients (APIs), thus forming therapeutic DESs (TheDESs). In this work, special attention is paid to DESs, presenting a precise definition, classification, methods of preparation, and characterization. A description of natural DESs (NaDESs), i. e., eutectic solvents present in natural sources, is also reported. Moreover, the present review article is the first one to detail the different approaches for judiciously selecting the constituents of DESs in order to minimize the number of experiments. The role of DESs in the biomedical and pharmaceutical sectors and their impact on the development of successful therapies are also discussed.
CCNB1IP1 prevents ubiquitination‐mediated destabilization of MYCN and potentiates tumourigenesis of MYCN‐amplificated neuroblastoma
Authors: Zhou Yang , Yan Hui , Zhou Qiang , Wang Penggao , Yang Fang , Yuan Ziqiao , Du Qianming , Zhai Bo 
Published: July 2023

AbstractBackgroundMYCN amplification as a common genetic alteration that correlates with a poor prognosis for neuroblastoma (NB) patients. However, given the challenge of directly targeting MYCN, indirect strategies to modulate MYCN by interfering with its cofactors are attractive in NB treatment. Although cyclin B1 interacting protein 1 (CCNB1IP1) has been found to be upregulated in MYCN‐driven mouse NB tissues, its regulation with MYCN and collaboration in driving the biological behaviour of NB remains unknown.MethodsTo evaluate the expression and clinical significance of CCNB1IP1 in NB patients, public datasets, clinical NB samples and cell lines were explored. MTT, EdU incorporation, colony and tumour sphere formation assays, and a mouse xenograft tumour model were utilized to examine the biological function of CCNB1IP1. The reciprocal manipulation of CCNB1IP1 and MYCN and the underlying mechanisms involved were investigated by gain‐ and loss‐of‐function approaches, dual‐luciferase assay, chromatin immunoprecipitation (CHIP) and co‐immunoprecipitation (Co‐IP) experiments.ResultsCCNB1IP1 was upregulated in MYCN‐amplified (MYCN‐AM) NB cell lines and patients‐derived tumour tissues, which was associated with poor prognosis. Phenotypic studies revealed that CCNB1IP1 facilitated the proliferation and tumourigenicity of NB cells in cooperation with MYCN in vitro and in vivo. Mechanistically, MYCN directly mediates the transcription of CCNB1IP1, which in turn attenuated the ubiquitination and degradation of MYCN protein, thus enhancing CCNB1IP1‐MYCN cooperativity. Moreover, CCNB1IP1 competed with F box/WD‐40 domain protein 7 (FBXW7) for MYCN binding and enabled MYCN‐mediated tumourigenesis in a C‐terminal domain‐dependent manner.ConclusionsOur study revealed a previously uncharacterized mechanism of CCNB1IP1‐mediated MYCN protein stability and will provide new prospects for precise treatment of MYCN‐AM NB based on MYCN‐CCNB1IP1 interaction.
Intratumoural microbiome can predict the prognosis of hepatocellular carcinoma after surgery
Authors: Sun Lejia , Ke Xindi , Guan Ai , Jin Bao , Qu Jiangming , Wang Yinhan , Xu Xiang , Li Changcan , Sun Hang , Xu Hengyi , Xu Gang , Sang Xinting , Feng Yifei , Sun Yueming , Yang Huayu , Mao Yilei 
Published: July 2023

AbstractBackgroundThe dismal prognosis of hepatocellular carcinoma (HCC) is closely associated with characteristics of the tumour microenvironment (TME). Recent studies have confirmed the presence and potential influence of the microbiome in TME on cancer progression. Elucidating the relationship between microbes in the TME and cancer could provide valuable insights into novel diagnostic markers and therapeutic strategies for HCC and thus warrants a closer investigation of the role of intratumoural microbiome in the HCC TME.MethodsWe determined the presence of intratumoural microbiome using fluorescence in situ hybridisation, and explored the microbial community profiles in the HCC TME in paired tumour and adjacent normal tissues using 16S rDNA sequencing. Microbial signatures were characterised in the paired group, and their correlation with clinical characteristics was further investigated. We clustered the microbial signatures of tumour tissues by hepatotypes, and further analysis was performed to elucidate the independent prognostic value of the hepatotypes.ResultsThis study revealed that microbial profiles and community networks differed notably between tumours and adjacent normal tissues. Proteobacteria and Actinobacteria were the most abundant phyla in the HCC TME. The TME microbial profiles also revealed heterogeneities between individuals and between multiple tumour lesions. Clustering of the microbial profiles into two hepatotypes revealed different microbial network patterns. Additionally, the hepatotypes were revealed to be independent prognostic factors in patients with resected HCC.ConclusionsOur study illuminates the microbial profiles in the TME of HCC and presents the hepatotype as a potential independent biomarker for the prognostic prediction of HCC after surgery.