bluuebunny/crossref_metadata_2025_split huggingface dataset:
Does fashion week enhance city brand equity? The impact of fashion destination experience on e-WOM and revisit intention
Authors: Cho Minjung , Ko Eunju 
Published: February 2025

Purpose
This study aims to investigate the impact of the fashion destination experience through fashion week on city brand equity, e-word of mouth and revisit intention.

Design/methodology/approach
A survey was conducted targeting 301 tourists who had previously visited Paris during fashion week. AMOS was used to carry out structural equation modeling analyses.

Findings
Fashion destination experience through the fashion week event positively affects city brand equity, e-WOM and intention to revisit the city. Perceived quality, one of the city brand equity’s attributes, had no significant influence on the intention to revisit in the context of fashion destination experience.

Originality/value
This study focuses on the role of fashion in the context of city brand equity and visitor behavior. The findings will help tourism managers understand the effect of fashion destination experiences during fashion week and develop city and tourism plans.
Postoperative Adjuvant Therapy Benefits Non‐pCR Patients Rather Than pCR Patients for Locally Advanced ESCC: A Multicenter Real‐World Study
Authors: Liu Defeng , Liu Ao , Guo Longxiang , Li Yi , Li Yuanlin , Chi Yuxiang , Lin Haiqun , Yu Jinming , Li Minghuan 
Published: February 2025

ABSTRACTBackgroundThere is no unified standard in adjuvant therapy (AT) for patients with esophageal squamous cell carcinoma (ESCC) after neoadjuvant therapy and surgery. We evaluated the significance of AT for these patients and explored its influencing factors.MethodsESCC patients who underwent neoadjuvant therapy and surgery from 2019 to 2022 at three centers were divided into AT (n = 227) and non‐AT groups (n = 435). Baseline characteristics were balanced using propensity score matching (PSM). Primary endpoints were disease‐free survival (DFS) and overall survival (OS), assessed using the Kaplan–Meier method. Subgroup analyses and univariate and multivariate Cox regression analyses were conducted to identify the prognostic factors.ResultsThe median follow‐up period is 36 (2–72) months. After PSM, the total population had 1‐, 2‐, and 3‐year OS rates of 71.3%, 66.0%, and 64.1%, respectively. There were no statistically significant differences in DFS (HR: 0.79; 95% CI: 0.55–1.14, p = 0.21) or OS (HR: 0.75; 95% CI: 0.49–1.13, p = 0.17) between AT and non‐AT groups. Subgroup analysis revealed that non‐pCR patients benefited from AT in DFS (p = 0.042) and OS (p = 0.033). Moreover, in non‐pCR patients who received AT, BMI ≥ 21.5 kg/m2 and ypN0 were independent protective factors of DFS. ypN0 was an independent protective factor of OS. In terms of AT regimens, the Kaplan–Meier analysis revealed that adjuvant immunochemotherapy (AICT) provided superior survival benefits than adjuvant radiotherapy and adjuvant chemotherapy.ConclusionsPostoperative AT benefited ESCC patients with non‐pCR, while AICT may be a relatively better AT regimen in real‐world data, which deserves further exploration.
Haematological and serum biochemical reference interval for free‐ranging northern bettongs (Bettongia tropica) in far north Queensland
Authors: Olsson A , Allanson A , L'Hotellier F 
Published: February 2025

BackgroundThe northern bettong, Bettongia tropica, is an endangered potoroid recognised as a specialist consumer of underground ectomycorrhizal fungi important to wet sclerophyll forest at the interface with tropical rainforest. In line with identified recovery objectives of re‐establishing populations within the species' former range, a founder population was translocated to a feral predator‐free fenced exclosure within previously occupied habitat to the south of its current range. No published reference intervals for haematology and serum biochemistry exist for this species. Establishing reference intervals provides a valuable tool for health assessment of founder animals and investigations into population health and disease during ongoing monitoring of populations.ObjectiveTo develop reference intervals for haematology and serum biochemistry parameters in northern bettongs, Bettongia tropica.MethodsHaematological and serum biochemical reference intervals were determined from 39 healthy northern bettongs captured across the Lamb Range region of north Queensland. Routine haematological and biochemical parameters were analysed, including blood gases and lactate, which indicate metabolic changes associated with stress.ResultsHaematological and serum biochemical parameters were similar to those reported from other potoroids, except for haematocrit and serum protein, which were elevated. Stress parameters were within normal limits. Macropod herpesvirus and Toxoplasma gondii were not detected.ConclusionsTranslocated northern bettongs were in good general health, and data collected at the time of capture were sufficient to establish a preliminary reference interval for the species. This provides baseline information by which to monitor health and welfare of the translocated population, and will contribute to health monitoring of other extant populations.
Loss of Function SPTAN1 Variants Result in Ataxia and Intellectual Disability
Authors: Lu Po‐Nien , Melton Chandler , Dupont Barbara , Jones Julie R. , Abidi Fatima , Rose Aubrey , Patterson Wesley G. , Lyons Michael J. , Flanagan‐Steet Heather 
Published: February 2025

ABSTRACTSPTAN1 mutations have been reported in association with autosomal dominant early infantile epileptic encephalopathy 5. Individuals present with early‐onset seizures and profound intellectual disability. Recent reports suggest a wider spectrum with later‐onset seizures and milder developmental delay. Here we describe two patients with loss‐of‐function variants in SPTAN1. One patient has ataxia and mild intellectual disability stemming from a de novo homozygous p.(Gln1448Pro) variant associated with uniparental disomy 9. The second patient, carrying a heterozygous p.(Asn1839del) allele, exhibits more substantial motor issues, developmental delay, and seizures. Ectopically expressed wild‐type or variant‐containing forms of sptan1 in zebrafish indicate both variants create loss‐of‐function alleles, with the p.(Gln1448Pro) likely being hypomorphic. This conclusion is supported by reduced protein abundance and localization of Sptan1 variants in axons of developing embryos. Further, unlike wild‐type sptan1, analysis of the p.(Gln1448Pro) variant showed it failed to restore voltage‐gated sodium channel localization in sptan1‐null axons. Additional behavioral analyses show supplementation with the amino acid D‐aspartate improved motility in sptan1‐null zebrafish, supporting its use for α‐II spectrin‐associated motor dysfunction.
Variation in Salmon Migration Phenology Bolsters Population Stability but Is Threatened by Drought
Authors: Baker Henry K. , Obedzinski Mariska , Grantham Theodore E. , Carlson Stephanie M. 
Published: February 2025

ABSTRACTIntrapopulation variation in movement is common in nature but its effects on population dynamics are poorly understood. Using movement data from 3270 individually‐marked fish representing nine cohorts of coho salmon (Oncorhynchus kisutch) in California, we show that bimodal intrapopulation variation in the timing of juvenile down‐migration from their natal habitat and subsequent residence in non‐natal habitat affects growth, emigration timing, and the abundance and stability of adult returns. Non‐natal fish (early down‐migrants) exhibited more variable growth and more variable but earlier emigration to the estuary than natal fish (late down‐migrants). While natal rearing was more common, non‐natal fish were overrepresented among adult returns, and total returns were 1.4 times more stable than natal returns alone. Our results demonstrate that variation in migratory behaviour bolsters population stability. However, non‐natal rearing is reduced in low water years, suggesting that drought exacerbates population instability by reducing critical intrapopulation variation.
Strengthening effect of flavonoid antioxidant on resin–enamel bond strength following tooth bleaching
Authors: Carvalho Gabriela Luiza Moreira , Carneiro Bruna Tavares , Kury Matheus , Fronza Bruna Marin , de Castro Fernanda Novais Arantes Maciel , Picolo Mayara Zaghi Dal , Cavalli Vanessa , André Carolina Bosso 
Published: February 2025

AbstractThis study aimed to assess the impact of flavonoid‐based antioxidant application after in‐office bleaching with 35% hydrogen peroxide on the shear bond strength of resin to bovine enamel, comparing it with 10% sodium ascorbate. Bovine enamel blocks (n = 10) were randomly assigned to one of five pretreatments: (i) no bleaching, (ii) bleaching without antioxidant application, and (iii) bleaching followed by a 1‐min application of 10% sodium ascorbate, (iv) 5% naringin, or (v) 10% naringin. Color analysis was conducted using a digital spectrophotometer. Shear bond strength was assessed on two, 2‐mm‐diameter resin cylinders per block using a universal testing machine at 0.5 mm/min until fracture. Enamel surface morphology was analyzed using scanning electron microscopy. Shear bond strength values and color parameters (ΔEab, ΔE00, and ΔWID) were analyzed using one‐way ANOVA, while t‐tests were used for the individual color parameters lightness (L*), green–red (a*), blue–yellow (b*), and chroma (C*)
. None of the antioxidants resulted in bond strength values as high as those observed without bleaching. However, application of sodium ascorbate and 5% naringin after bleaching significantly increased bond strength compared with bleached enamel without antioxidant. Antioxidants had no significant impact on color. The predominant failure modes were adhesive between the adhesive and enamel, and mixed.
Promoting Customer Engagement and Brand Loyalty on Social Media: The Role of Virtual Influencers
Authors: Vo Tram‐Huong , Wei‐Han Tan Garry , Pham Nhat Tan , Truong Thuy Hong‐Dinh , Ooi Keng‐Boon 
Published: February 2025

ABSTRACTThis study analyzes how virtual influencer factors influence customer engagement and brand loyalty using both parasocial theory and source credibility model. Further, it highlights the importance of incorporating the right influencer marketing orientation with a brand's positioning strategy. First, a quantitative survey was conducted with a sample size of 406 participants which was analyzed using PLS‐SEM technique. Subsequently, semi‐structured interviews were conducted with virtual influencer followers to explore the influencers' impact on the behavioral responses of customers towards a brand. The findings reveal that only trustworthiness and authenticity positively influence engagement, while parasocial interaction is a major driver of affective reactions, leading to higher engagement. Thus, parasocial interaction, authenticity, and trustworthiness collectively explain the intensity of engagement, which, in turn influences brand loyalty. Our study presents a surprising result that attractiveness of virtual influencers is not directly associated to customer engagement. Further, the study highlights virtual influencers' role in strengthening long‐term customer‐brand relationships and enhancing a loyal fan base for brands. In conclusion, by utilizing their potential influence, brands can improve their overall efficacy of marketing communications in facilitating customer engagement to foster loyalty.
The Association of Intake of Vitamin Mixtures With Periodontitis: A Machine Learning Approach on NHANES
Authors: Zhang Qinglian , Que Hanxin , Xu Shengming , Xu Leyan , Lin Jian , Deng Hui , Deng Ke , Wang Yi 
Published: February 2025

ABSTRACTAimsPrevious studies have focused on the association of single vitamin intake with periodontitis. However, the consumption of vitamins is commonly in the form of mixtures. The relationship between the consumption of multiple vitamins and the prevalence of periodontitis needs to be investigated.MethodsIn this cross‐sectional study, 8512 participants with full‐mouth periodontal examination records and vitamin intake (vitamins A, B1, B2, B6, B12, C, D, E, and K) data from the US National Health and Nutrition Examination Survey (NHANES, 2009–2014) datasets were included. GLM and Bayesian kernel machine regression (BKMR) were used to estimate the association of individual and mixed vitamins with periodontitis, respectively. Sensitivity analyses were performed using mean probing depth and mean clinical attachment loss as continuous indicators of periodontitis severity.ResultsVitamins A (OR = 0.90, 95% CI: 0.95–0.99) and E (OR = 0.95, 95% CI: 0.93–0.97) were both negatively associated with periodontitis in GLM estimates and BKMR modeling in the context of vitamin mixtures. Moreover, the intake of vitamin mixtures within a certain range (< 75% percentile) was negatively associated with the estimated risk of periodontitis, which was predominantly driven by vitamins A and E. A potential interaction between vitamins A and E in their association with periodontitis was observed. Similar findings were found in sensitive analyses.ConclusionsBKMR estimates suggested that higher intake of vitamin mixtures might account for decreased odds of periodontitis, with vitamins A and E identified as the most influential factors. Future studies are highly warranted to clarify the underlying mechanisms.
Molecular analyses reveal a misidentification of Gracilaria parvisporaAbbott 1985 (Gracilariales, Rhodophyta) in the southern Mexican Pacific and the proposal of Gracilaria huavensis sp. nov.
Authors: Acosta Calderón Julio A. , Rosas Alquicira Edgar F. , González Nataly Quiroz , de Jesús Trejo Méndez María , Villanueva Valentina Islas 
Published: February 2025

SUMMARYCylindrical red algae of the genus Gracilaria from the coastal lagoons of the Southern Mexican Pacific are described as a new species, G. huavensis sp. nov. based on rbcL and COI‐5P sequence analyses and detailed morphological, anatomical, and reproductive characteristics. This species typically grows in the intertidal and subtidal in brackish lagoons in the Southern Mexican Pacific. It is characterized by its percurrent cylindrical thalli with one to three orders of ramification with acute unilateral branchlets. Spermatangial conceptacles are of the textorii‐type. Cystocarps are spherical and possess numerous nutritive filaments at lateral and basal positions in the cystocarp cavity. Gracilaria huavensis is morphologically like G. parvispora but differs genetically. This species has been typically misidentified as G. parvispora but the clades formed by the Southern Mexican lagoons specimens for both markers were clearly separated from the G. parvispora sequences from Hawaii, Japan, South Korea, and Baja California Sur. Genetic distances between the Southern Mexican Pacific specimens and G. parvispora sequences were 1–1.6% in rbcL and 2.5–2.7% in COI‐5P. The morphological similarity between both species is the main cause of misidentifications. The occurrence of Asiatic G. parvispora in the Southern Mexican Pacific was not confirmed in this study, highlighting the need for molecular confirmation of species with problematic taxonomy.
Numerical study on conjugate heat and mass transfer characteristics around thermosolutal exchangers: Effect of flow parameters and solid block arrangement
Authors: Shivli  , Nayak Ameeya K. 
Published: February 2025

Abstract
The effect of air-flow characteristics within a slot-ventilated enclosure is carried out numerically to optimize the heat and contaminants removal rate where the cold fresh air is injected through an inlet port. The contaminated air is expelled by the chimney outlet port positioned along the left side of the upper wall. Based on the structure dynamics the flow governing equation is dealt by the Navier-Stokes equations coupled with the energy equation, where the maximum cooling efficiency is evaluated. A finite volume-based SIMPLE (Semi-Implicit Method for Pressure Linked Equations) method is employed to dealt with the nonlinear coupled partial differential equations to evaluate the flow variation with changing various physical parameters. To study the effective variation of heat transfer arisen in a natural chamber, different thermosolutal blocks with orientations are considered. The inclination angle of the chimney, Richardson number and Reynolds number on the average heat and mass transfer rate and average temperature inside the system is evaluated. Scaling analysis is performed to investigate the transient behavior of the boundary-layer flow that is dominated by natural convection near the inlet port on the enclosure's left wall and found that the results are in good agreement with our numerical results.
Influence of Step Rate Manipulation on Foot Strike Pattern and Running Economy
Authors: Kim Youngwook , Richardson Janae L. , Bressel Eadric 
Published: February 2025

Context: With the rise in distance running, there is an increasing interest in reducing running-related injuries and improving performance. Foot strike patterns (FSP) and step rate (SR) are key factors in managing the external forces generated during foot contact in running. Adjusting SR may help alter FSP and improve running economy (RE), yet its effects on recreational runners are not fully understood. Thus, this study aimed to examine if SR manipulations are sufficient to shift FSP and whether the manipulations change the RE. Design: Cross-sectional study. Methods: Eighteen healthy recreational runners’ (age: 30.2 [7.6] y) foot strike angle was calculated using 2D video motion analysis, and submaximal VO2 was measured while running on a treadmill during preferred and adjusted (±5% and ±10%) SR conditions. Foot strike angle was used to predict strike index and quantify FSP, and submaximal VO2 was analyzed to determine RE. Results: Predicted strike index was significantly different between preferred SR and the −10% (P = .002), −5% (P = .002), and +10% (P < .001) SR conditions. Submaximal VO2 was significantly increased in the −10% (P < .001) and −5% (P = .002) SR conditions. Conclusion: SR manipulations were sufficient to alter foot strike angle and predicted strike index in recreational runners, leading to moderate to significant changes in RE. These findings suggest that SR manipulation can be a useful tool for influencing FSPs and optimizing RE to enhance performance and reduce injury risk.
Safety and effectiveness of anticoagulation therapy in older people with atrial fibrillation during exposed and unexposed treatment periods
Authors: Mitchell Anneka , Watson Margaret C , Welsh Tomas J , McGrogan Anita 
Published: February 2025

Background
Anticoagulation therapy reduces stroke risk in patients with atrial fibrillation (AF), but it is often underused in older populations due to concerns about bleeding. This study aimed to compare the safety and effectiveness of anticoagulation during periods of exposure and non-exposure and across different anticoagulants in people with AF aged ≥75 years.

Methods
Using UK primary care data from the Clinical Practice Research Datalink (2013–2017), a retrospective cohort study was conducted on patients newly prescribed oral anticoagulants (warfarin or direct oral anticoagulants). Exposure to anticoagulation was mapped using prescription data. Cox regression models were used to estimate adjusted HRs for stroke, bleeding, myocardial infarction, and death during periods of exposure and non-exposure and for different anticoagulants.

Results
Among 20 167 patients (median age 81 years), non-exposure to anticoagulation was associated with higher risks of stroke (HR 3.07, 95% CI 2.39 to 3.93), myocardial infarction (HR 1.85, 95% CI 1.34 to 2.56) and death (HR 2.87, 95% CI 2.63 to 3.12) compared with exposure. Compared with warfarin, apixaban was associated with lower risks of non-major bleeding (HR 0.73, 95% CI 0.64 to 0.85), whereas rivaroxaban was associated with higher risks of major (HR 1.33, 95% CI 1.15 to 1.55) and non-major (HR 1.29, 95% CI 1.16 to 1.44) bleeding.

Conclusions
Non-exposure to anticoagulation increases the risks of stroke, myocardial infarction and death in older patients with AF. Clinicians should carefully weigh the risks of discontinuing anticoagulation and provide shared decision-making support to patients, especially when considering deprescription.
A Systematic Review with a Demonstrative Case of KIT and DOG-1 Expressing Gastrointestinal Stromal Tumors Harboring ETV6-NTRK3 Fusions
Authors: Ranjbarian Tannaz , Antkowiak Mark , Mallory Robert J. , Doherty Terence M. , Hosseini Mojgan , Mesirov Jill P. , Fanta Paul T. , Sicklick Jason K. 
Published: February 2025

Abstract
Introduction: Previous reports have described ETV6-NTRK3 fusion-positive gastrointestinal stromal tumors (GISTs) in cases lacking KIT, PDGFRA, RAS-pathway, or SDHx alterations. However, some investigators have questioned the rigor of these reports and the true existence of NTRK rearrangements in GIST. This study aims to: 1) resolve whether NTRK gene rearrangements exist in GIST; 2) review the relevant literature; and 3) demonstrate a case of NTRK fusion GIST. Methods: A comprehensive literature review using PubMed identified additional NTRK fusion-reported cases. Under an IRB-approved protocol, we describe a patient with biopsy-proven GIST who underwent genomic and transcriptomic CLIA-certified testing, precision-matched therapy, surgical resection, and pathological analysis. Results: We identified 17 reported cases of GIST with NTRK fusions. Five studies reported GIST with KIT/DOG-1 expression by IHC, wild-type KIT/PDGFRA, and an ETV6-NTRK3 fusion, consistent with GIST. We demonstrate a case of a 72-year-old female status post resection of a high-risk gastric GIST followed by 45 months of adjuvant imatinib. She developed recurrent disease and biopsy revealed mixed epithelioid and spindleoid GIST with IHC expression of KIT (CD117) and DOG-1. Imatinib was re-initiated, but her disease progressed, prompting molecular testing for the first time. RNA sequencing identified an in-frame fusion of ETV6 with NTRK3. Larotrectinib, a pan-NTRK inhibitor, was initiated for 7 months, resulting in shrinkage in five tumors (range: 4.2–77%). Surgical cytoreduction demonstrated a pathological near complete response (1% viable tumor cells). Conclusion: Our findings confirm the existence of ETV6-NTRK3 fusion GIST and demonstrate that these imatinib-resistant GISTs may be exquisitely sensitive to TRK