bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Impact of Human Resources Practices on Organizational Performance: Mediating Role of Supply Chain Operational Performance Among Pakistani Smes
Authors: Shahzadi Sidra , Samikon Siti Aida , Shahzad Imran Ahmed , Shahzadi Yusra 
Published: July 2023

Purpose: The primary aim of this quantitative study was to test the impact of the cultural capabilities and training & Development on Organizational Performance of Pakistani SMEs. In order to achieve the goals of the study, literature review has been done; tools and seven hypotheses were developed.

Methodology: data have been collected through structured self-administered questionnaire adopted and adapted from the earlier similar studies. Based on 62 itemized survey, data have been collected from 379 Pakistani SMEs situated in ten cities. A pilot study was conducted and data analysis techniques as; Descriptive, Pearson Correlation, Regression, Convergent Validity, Discriminate validity, Composite reliability, Partial Least Square through Structural Educational Modeling, are employed to check the reliability, validity of model fitness and testing the hypotheses.

Conclusion: Study methodologies can include structural equation modelling and enhanced monitoring of supply chain management as well facilitating to their success can be resulted from the continued research in this area, as well as application of the model to different enterprises and situations.

Implications: This study provided guidance and controlling panel for the Small and Medium Enterprises Authority (SMEs) of Pakistani government at first place as it advises either SMEDA should pay attention to modernize SMEs with the help of technology and influence performance of industry. Future study may employ other methodologies to evaluate and confirm the currently presented casual links.
The Arab East: Civil Aviation in the Light of Modern Challenges
Authors: Isaev V. A. , Filonik A. O. 
Published: July 2023

The article analyzes the features of the development of civil aviation in the Arab East with an emphasis on the beginning of the current century, as the most important period in the life of the Arab nations, on the one hand the time when they suffered huge losses as a result of the global financial crisis, the drama of the Arab Spring, the wars on terrorism, the pandemic and other circumstances, and on the other — t he time when they managed to accumulate colossal oil revenues, which were invested in economic construction and especially in infrastructure, including its aviation part. The article is built around a description of the contrasts between Arabian oil exporters and the Arab outsiders, whose difference in growth potentials is exacerbated by the pitfalls and traps of the so-called catch-up development. This model a priori puts weak facilities at a disadvantage, since less wealthy countries experience the greatest difficulties in overcoming problems and challenges across the entire range of socio-economic development topics compared to those that form the basis of infrastructure construction, including the aviation services industry. The article emphasizes that the reduction of the gap in terms of the maturity of transport and logistics connectivity in the region, along with other advances and developments in the field of transport arrangement of the Middle East and North African economic space, could potentially in the future create conditions for a more representative presence of the Arab nations in the system of world economic ties, and at the shorter-range stages of growth it will more fully ensure the current and ongoing tasks and objectives of regional intersectoral and intra-economic connectivity in the interests of integration.
Қазақстандағы отбасылық және гендерлік саясат ұстанымдары мен оларды қоғам мен мемлекет тарапынан қолдау
Authors: Акыбаева Г.С. , Мусатаев Б.Б. , Мамбетова С.Ш. , Ахметова А.С. , Орынбасаров С.О. 
Published: July 2023

Мақсаты: Мақалада Қазақстан Республикасындағы ағымдағы гендерлік үдерістер қоғам мен мемлекет тарапынан қолдау тұрғысынан талданған. Заңнамалық және институционалдық деңгейде гендерлік теңдікке қол жеткізудің негізгі мәселелері, Қазақстан әйелдерінің экономикалық ілгерілеуінің мәселелері айқындалған.
Әдісі: Елімізде гендерлік саясатты тиімді жүзеге асыру үшін институционалдық және нормативтік база құрылған. Қазақстандық қоғам өмірінің барлық салаларында гендерлік теңдікті қамтамасыз ету үшін жоғары мемлекеттік деңгейде гендерлік саясат институты ― Қазақстан Республикасы Президентінің жанындағы Әйелдер істері және отбасылықдемографиялық саясат жөніндегі ұлттық комиссиясының маңызды әдістері қолданылды.
Қорытынды: Мақалада Қазақстан Республикасының Конституциясында және Қазақстан қосылған халықаралық актілерде жарияланған ерлер мен әйелдердің тең құқықтары мен тең мүмкіндіктерін жүзеге асыру, сондай-ақ олардың қоғамның барлық салаларына тең қатысуы үшін жағдай жасау жөнінде ұсыныстар берілген.
Тұжырымдама: Қолданылатын әдістер негізінде Қазақстанның мемлекеттік гендерлік саясаты барлық салаларда барынша гендерлік теңдікті қамтамасыз ететін жаңа қоғамдық қатынастарды құруға мүмкіндік беретін нормаларды, стандарттарды, даму негіздерін, бағыттарын, шектеулері мен бостандықтарын қамтиды. Белгілі бір қоғамда белгілі бір өндіріс тәсілі мен белгілі бір тарихи қатынастар үшін идеялар мен ережелер жүйесі анықталады.
Analysis of transjugular intrahepatic portosystemic shunt by hemodynamic simulation
Authors: Cao Junjie , Yao Zhichao , Huo Guijun , Liu Zhanao , Tang Yao , Huang Jian , Chen Minxin , Ding Rui , Shen Liming , Zhou Dayong 
Published: July 2023

BACKGROUND: Transjugular intrahepatic portosystemic shunt (TIPS), which artificially creates a portocaval shunt to reduce portal venous pressure, has gradually become the primary treatment for portal hypertension (PH). However, there is no prefect shunting scheme in TIPS to balance the occurrence of postoperative complications and effective haemostasis. OBJECTIVE: To construct cirrhotic PH models and compare different shunting schemes in TIPS. METHODS: Three cases of cirrhotic PH with different liver volumes were selected for enhanced computed tomography scanning. The models for different shunting schemes were created using Mimics software, and following FLUENT calculation, all the models were imported into the software computational fluid dynamic-post for processing. In each shunting scheme, the differences in portal vein pressure, hepatic blood perfusion and blood flow from the superior mesenteric vein in the shunt tract were compared. The coefficient G was adapted to evaluate the advantages and disadvantages. RESULTS: (1) Concerning the precise location of the shunt tract, the wider the diameter of the shunt tract, the lower the pressure of the portal vein and the lesser the hepatic blood perfusion. Meanwhile, the pressure drop objective was not achieved with the 6 mm-diameter shunting scheme. (2) The 8 mm-diameter shunting scheme through the left portal vein (LPV) had the highest coefficient G. CONCLUSION: The 8 mm-diameter shunting scheme through the LPV may demonstrate a superior effect and prognosis in TIPS procedures.
Liver cancer classification via deep hybrid model from CT image with improved texture feature set and fuzzy clustering based segmentation
Authors: Tejaswi Vinnakota Sai Durga , Rachapudi Venubabu 
Published: July 2023

One of the leading causes of death for people worldwide is liver cancer. Manually identifying the cancer tissue in the current situation is a challenging and time-consuming task. Assessing the tumor load, planning therapies, making predictions, and tracking the clinical response can all be done using the segmentation of liver lesions in Computed Tomography (CT) scans. In this paper we propose a new technique for liver cancer classification with CT image. This method consists of four stages like pre-processing, segmentation, feature extraction and classification. In the initial stage the input image will be pre processed for the quality enhancement. This preprocessed output will be subjected to the segmentation phase; here improved deep fuzzy clustering technique will be applied for image segmentation. Subsequently, the segmented image will be the input of the feature extraction phase, where the extracted features are named as Improved Gabor Transitional Pattern, Grey-Level Co-occurrence Matrix (GLCM), Statistical features and Convolutional Neural Network (CNN) based feature. Finally the extracted features are subjected to the classification stage, here the two types of classifiers used for classification that is Bi-GRU and Deep Maxout. In this phase we will apply the Crossover mutated COOT optimization (CMCO) for tuning the weights, So that we will improve the quality of the image. This proposed technique, present the best accuracy of disease identification. The CMCO gained the accuracy of 95.58%, which is preferable than AO = 92.16%, COA = 89.38%, TSA = 88.05%, AOA = 92.05% and COOT = 91.95%, respectively.
Retrograde type A aortic dissection during or after thoracic endovascular aortic repair: a single center 16-year experience
Authors: Wang Guo-quan , Qin Ya-fei , Shi Shuai-tao , Zhang Ke-wei , Zhai Shui-ting , Li Tian-xiao 
Published: July 2023

ObjectiveThis article aims to investigate the incidence rate of retrograde type A aortic dissection (RTAD) and the risk factors of RTAD in relation to thoracic endovascular aortic repair (TEVAR).MethodsPatients with thoracic aortic disease who underwent TEVAR at Henan Provincial People's Hospital from January 2004 to December 2019 were enrolled in the present research. The risk factors associated with RTAD following TEVAR using univariate and multiple logistic regression analyses.ResultsDuring the study period, A total of 1,688 TEVAR patients were included in this study, and of these, 1,592 cases were included in the type B aortic dissection (TBAD) group, and 96 cases were included in the non-TBAD group. There were 1,230 cases of aortic dissection and 362 cases of aortic intramural hematoma and/or penetrating ulcer in the TBAD group. The non-TBAD group included 68 cases of thoracic aortic aneurysm, 21 cases of thoracic aortic pseudoaneurysm, and seven cases of congenital aortic coarctation. The overall incidence rate of RTAD was 1.1% (18/1,688) in patients, all of which occurred in the TBAD group. The cohort comprised 18 RTAD patients with an average age of 56.78, consisting of 13 males and 5 females. Among them, 13 individuals exhibited hypertension. Ten instances happened within the TEVAR perioperative period, including two cases during the surgery, six cases occurred within three months, two cases occurred after one year, and the longest interval was 72 months following TEVAR. TEVAR was successfully implemented in 17 patients, while the operation technique was temporarily altered in one case. The new entry position for RTAD was identified as the proximal region of the stent graft (SG) in 13 patients, while in five cases, the entry site was more than 2 cm away from the proximal region of the SG. 17 cases were at the greater curvature of the aorta, and one case was at the lesser curvature. Multivariate logistic regression analysis revealed that the SG oversizing ratio is a relevant risk factor for RTAD. However, ascending aortic diameter, aortic arch type, SG type, and anchored region were not directly related to the occurrence of RTAD.ConclusionRTAD is a rare yet catastrophic complication. It could occur both during the procedure, early and late postoperative periods. Maintaining an appropriate SG oversizing ratio is crucial to minimize the risk of RTAD.
mDIXON-Quant for differentiation of renal damage degree in patients with chronic kidney disease
Authors: Wang Yue , Ju Ye , An Qi , Lin Liangjie , Liu Ai Lian 
Published: July 2023

BackgroundChronic kidney disease (CKD) is a complex syndrome with high morbidity and slow progression. Early stages of CKD are asymptomatic and lack of awareness at this stage allows CKD to progress through to advanced stages. Early detection of CKD is critical for the early intervention and prognosis improvement.PurposeTo assess the capability of mDIXON-Quant imaging to detect early CKD and evaluate the degree of renal damage in patients with CKD.Study typeRetrospective.Population35 patients with CKD: 18 cases were classifified as the mild renal damage group (group A) and 17 cases were classifified as the moderate to severe renal damage group (group B). 22 healthy volunteers (group C).Field strength/sequenceA 3.0 T/T1WI, T2WI and mDIXON-Quant sequences.AssessmentTransverse relaxation rate (R2*) values and fat fraction (FF) values derived from the mDIXON-Quant were calculated and compared among the three groups.Statistical testsThe intra-class correlation (ICC) test; Chi-square test or Fisher’s exact test; Shapiro-Wilk test; Kruskal Wallis test with adjustments for multiplicity (Bonferroni test); Area under the receiver operating characteristic (ROC) curve (AUC). The significance threshold was set at P &lt; 0.05.ResultsCortex FF values and cortex R2* values were significantly different among the three groups (P=0.028, &lt;0.001), while medulla R2* values and medulla FF values were not (P=0.110, 0.139). Cortex FF values of group B was significantly higher than that of group A (Bonferroni adjusted P = 0.027). Cortex R2* values of group A and group B were both significantly higher than that of group C (Bonferroni adjusted P = 0.012, 0.001). The AUC of cortex FF values in distinguishing group A and group B was 0.766. The diagnostic efficiency of cortex R2* values in distinguishing group A vs. group C and group B vs. group C were 0.788 and 0.829.ConclusionThe mDIXON-Quant imaging had a potential clinical value in early diagnosis of CKD and assessing the degree of renal damage in CKD patients.
NVX-CoV2373-induced T- and B-cellular immunity in immunosuppressed people with multiple sclerosis that failed to respond to mRNA and viral vector SARS-CoV-2 vaccines
Authors: Mueller-Enz Magdalena , Woopen Christina , Katoul Al Rahbani Georges , Haase Rocco , Dunsche Marie , Ziemssen Tjalf , Akgün Katja 
Published: July 2023

ImportanceImmunological response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination is important, especially in people with multiple sclerosis (pwMS) on immunosuppressive therapies.ObjectiveThis study aims to determine whether adjuvanted protein-based vaccine NVX-CoV2373 is able to induce an immune response to SARS-CoV-2 in pwMS with inadequate responses to prior triple mRNA/viral vector vaccination.Design, setting, and participantsWe conducted a single-center, prospective longitudinal cohort study at the MS Center in Dresden, Germany. In total, 65 participants were included in the study in accordance with the following eligibility criteria: age &gt; 18 years, immunomodulatory treatment, and insufficient T-cellular and humoral response to prior vaccination with at least two doses of SARS-CoV-2 mRNA (BNT162b2, mRNA-1273) or viral vector vaccines (AZD1222, Ad26.COV2.S).InterventionsIntramuscular vaccination with two doses of NVX-CoV2373 at baseline and 3 weeks of follow-up.Main outcomes and measuresThe development of SARS-CoV-2-specific antibodies and T-cell responses was evaluated.ResultsFor the final analysis, data from 47 patients on stable treatment with sphingosine-1-phosphate receptor (S1PR) modulators and 17 on ocrelizumab were available. The tolerability of the NVX-CoV2373 vaccination was overall good and comparable to the one reported for the general population. After the second NVX-CoV2373 vaccination, 59% of S1PR-modulated patients developed antispike IgG antibodies above the predefined cutoff of 200 binding antibody units (BAU)/ml (mean, 1,204.37 [95% CI, 693.15, 2,092.65] BAU/ml), whereas no clinically significant T-cell response was found. In the subgroup of the patients on ocrelizumab treatment, 23.5% developed antispike IgG &gt; 200 BAU/ml (mean, 116.3 [95% CI, 47.04, 287.51] BAU/ml) and 53% showed positive spike-specific T-cellular responses (IFN-gamma release to antigen 1: mean, 0.2 [95% CI, 0.11, 0.31] IU/ml; antigen 2: mean, 0.24 [95% CI, 0.14, 0.37]) after the second vaccination.ConclusionsVaccination with two doses of NVX-CoV2373 was able to elicit a SARS-CoV-2-specific immune response in pwMS lacking adequate immune responses to previous mRNA/viral vector vaccination. For patients receiving S1PR modulators, an increase in anti-SARS-CoV-2 IgG antibodies was detected after NVX-CoV2373 vaccination, whereas in ocrelizumab-treated patients, the increase of antiviral T-cell responses was more pronounced. Our data may impact clinical decision-making by influencing the preference for NVX-CoV2373 vaccination in pwMS receiving treatment with S1PR modulation or anti-CD20 treatment.
Oral prednisolone suppresses skin inflammation in a healthy volunteer imiquimod challenge model
Authors: Assil Salma , Buters Thomas P. , Hameeteman Pieter W. , Hallard Charlie , Treijtel Nicoline , Niemeyer – Van der Kolk Tessa , de Kam Marieke L. , Florencia Edwin F. I. I. I. , Prens Errol P. , van Doorn Martijn B. A. , Rissmann Robert , Klarenbeek Naomi B. , Jansen Manon A. A. , Moerland Matthijs 
Published: July 2023

Imiquimod (IMQ) is a topical agent that induces local inflammation via the Toll-like receptor 7 pathway. Recently, an IMQ-driven skin inflammation model was developed in healthy volunteers for proof-of-pharmacology trials. The aim of this study was to profile the cellular, biochemical, and clinical effects of the marketed anti-inflammatory compound prednisolone in an IMQ model. This randomized, double-blind, placebo-controlled study was conducted in 24 healthy volunteers. Oral prednisolone (0.25 mg/kg/dose) or placebo (1:1) was administered twice daily for 6 consecutive days. Two days after treatment initiation with prednisolone or placebo, 5 mg imiquimod (IMQ) once daily for two following days was applied under occlusion on the tape-stripped skin of the back for 48 h in healthy volunteers. Non-invasive (imaging and biophysical) and invasive (skin punch biopsies and blister induction) assessments were performed, as well as IMQ ex vivo stimulation of whole blood. Prednisolone reduced blood perfusion and skin erythema following 48 h of IMQ application (95% CI [−26.4%, −4.3%], p = 0.0111 and 95% CI [−7.96, −2.13], p = 0.0016). Oral prednisolone suppressed the IMQ-elevated total cell count (95% CI [−79.7%, −16.3%], p = 0.0165), NK and dendritic cells (95% CI [−68.7%, −5.2%], p = 0.0333, 95% CI [−76.9%, −13.9%], p = 0.0184), and classical monocytes (95% CI [−76.7%, −26.6%], p = 0.0043) in blister fluid. Notably, TNF, IL-6, IL-8, and Mx-A responses in blister exudate were also reduced by prednisolone compared to placebo. Oral prednisolone suppresses IMQ-induced skin inflammation, which underlines the value of this cutaneous challenge model in clinical pharmacology studies of novel anti-inflammatory compounds. In these studies, prednisolone can be used as a benchmark.
FGF/FGFR1 system in paired breast tumor-adjacent and tumor tissues, associations with mammographic breast density and tumor characteristics
Authors: Boraka Öykü , Klintman Marie , Vallon-Christersson Johan , Zackrisson Sophia , Hall Per , Borgquist Signe , Rosendahl Ann H. 
Published: July 2023

IntroductionMammographic breast density (MBD) is an established breast cancer risk factor, yet the underlying molecular mechanisms remain to be deciphered. Fibroblast growth factor receptor 1 (FGFR1) amplification is associated with breast cancer development and aberrant FGF signaling found in the biological processes related to both high mammographic density and breast cancer microenvironment. The aim of this study was to investigate the FGF/FGFR1 expression in-between paired tumor-adjacent and tumor tissues from the same patient, and its associations with MBD and tumor characteristics.MethodsFGFR1 expression in paired tissues from 426 breast cancer patients participating in the Karolinska Mammography Project for Risk Prediction of Breast Cancer (KARMA) cohort study was analyzed by immunohistochemistry. FGF ligand expression was obtained from RNA-sequencing data for 327 of the included patients.ResultsFGFR1 levels were differently expressed in tumor-adjacent and tumor tissues, with increased FGFR1 levels detected in 58% of the tumors. High FGFR1 expression in tumor tissues was associated with less favorable tumor characteristics; high histological grade (OR=1.86, 95% CI 1.00–3.44), high Ki67 proliferative index (OR=2.18, 95% CI 1.18–4.02) as well as tumors of Luminal B-like subtype (OR=2.56, 95%CI 1.29–5.06). While no clear association between FGFR1 expression and MBD was found, FGF ligand (FGF1, FGF11, FGF18) expression was positively correlated with MBD.DiscussionTaken together, these findings support a role of the FGF/FGFR1 system in early breast cancer which warrants further investigation in the MBD–breast cancer context.
Association between media exposure and behavioral problems among preschool children
Authors: Zoromba Mohamed A. , Abdelgawad Doaa , Hashem Sahar , El-Gazar Heba , Abd El Aziz Magda Ahmed 
Published: July 2023

BackgroundThe prevalence of behavioral problems among preschool children is remarkably increasing in the clinical setting.AimThe current study aimed to investigate the association between media exposure and behavioral problems among preschool children.MethodsThis survey study recruited 560 children from 10 nurseries selected randomly, located in El-Mansoura, Egypt. Tools included socio-demographic characteristics the Media Exposure Questionnaire and the Conners Comprehensive Behavior Rating Scales (CBRS-48).ResultsThe participants were exposed to media for an average of 105.84 min per day and displayed moderate levels in all subscales of CBRS-48. The duration of media exposure was significantly correlated to the hyperactivity index, learning problems, hyperactivity/impulsivity, conduct problem, anxiety, and psychosomatic problems (r = 0.372, 0.356, 0.323, 0.306, 0.298, 0.291, and 0.255, respectively).ConclusionThe duration of media exposure was significantly correlated to the subscales of CBRS-48.Implication for nursing practicePreschool children should be engaged in concrete activities and social interactions that may lessen negative media effects such as hyperactivity, learning problems, hyperactivity/impulsivity, conduct problem, anxiety, and psychosomatic problems.