bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of Plant-Based Extract Mixture on Alcohol Metabolism and Hangover Improvement in Humans: A Randomized, Double-Blind, Paralleled, Placebo-Controlled Clinical Trial
Authors: Jung Seung Hee , Lee Yun Ha , Lee Eun Kyu , Park Soo-Dong , Shim Jae-Jung , Lee Jung-Lyoul , Yoo Hye Hyun 
Published: August 2023

Hangovers are uncomfortable physiological symptoms after alcohol consumption caused by acetaldehyde, a toxic substance in which alcohol is metabolized by alcohol dehydrogenase (ADH). Rapid alcohol and acetaldehyde decomposition are essential to alleviate alcohol handling symptoms. This study investigated the effects of HY_IPA combined with Mesembryanthemum crystallinum, Pueraria lobata flower, and Artemisia indica on alleviating hangovers. A randomized, double-blind, parallel-group, placebo-controlled clinical study was conducted on 80 individuals with hangover symptoms. Alcohol intake was 0.9 g/bw with 40% whiskey, adjusted proportionately to body weight. The Acute Hangover Scale total score was 5.24 ± 5.78 and 18.54 ± 18.50 in the HY_ IPA and placebo groups, respectively (p < 0.0001). All nine indicators of the hangover symptom questionnaire were significantly improved in the HY_IPA group (p < 0.01). Blood alcohol and acetaldehyde concentrations rapidly decreased from 30 min in the HY_IPA group (p < 0.05). ADH and acetaldehyde dehydrogenase (ALDH) activities in the blood of the HY_IPA group were significantly higher than those in the placebo group at 0, 1, and 2 h after alcohol consumption (p < 0.01). The rapid hangover relief was due to increased ADH and ALDH. Therefore, HY_IPA effectively relieves hangover symptoms by decomposing alcohol and acetaldehyde when consumed before alcohol consumption.
The Effect of Delivery Matrix on Bifidobacterium animalis subsp. lactis HN019 Survival through In Vitro Human Digestion
Authors: Yeung Nicolas , Forssten Sofia D. , Saarinen Markku T. , Anjum Mehreen , Ouwehand Arthur C. 
Published: August 2023

Bifidobacterium animalis subsp. lactis HN019 is a probiotic with several documented human health benefits. Interest in probiotics has led to the development of new formats that probiotics, including HN019, can be supplemented into. In this study, we looked at common HN019 formats such as frozen culture and freeze-dried powder as well as supplementing it into the following food matrices: yogurts (dairy, soy, and oat based), xanthan gum-based tablets, pulpless orange juice, whey sports drink, and dark chocolate (70% cocoa). In this work, our aim was to investigate whether the food matrix that carried HN019 via simulated human digestion (a dual model system mimicking both upper and lower gastrointestinal digestion) influenced probiotic delivery. To that end, we validated and used a real-time qPCR assay to detect HN019 after simulated digestion. In addition, we also measured the effect on a panel of metabolites. After simulated digestion, we were able to detect HN019 from all the matrices tested, and the observed changes to the metabolite profile were consistent with those expected from the food matrix used. In conclusion, this work suggests that the food matrix supplemented with HN019 did not interfere with delivery to the colon via simulated human digestion.
Private prescribing of controlled opioids in England, 2014–2021: a retrospective observational study
Authors: Martus Isabella , MacKenna Brian , Rial William , Hayhurst Jon , Richards Georgia C 
Published: August 2023

BackgroundTrends in NHS opioid prescribing have been well published, yet trends in private prescribing of opioids have not been widely established.AimTo assess trends and geographical variation in controlled opioids prescribed by private prescribers in England.Design and settingThis was a retrospective observational study in English primary health care.MethodData on Schedule 2 and 3 controlled opioids (‘controlled opioids’) were obtained from the NHS Business Services Authority (BSA) using Freedom of Information (FOI) requests between 1 January 2014 and 30 November 2021. Absolute counts and rates of the number of items dispensed per cumulative number of registered private prescribers were calculated and stratified over time, by opioid type, and geographical region.ResultsThis study found that 128 341 items of controlled opioids were prescribed by private prescribers in England between January 2014 and November 2021, which decreased by 50% from 23 339 items (4.09 items/prescriber) in 2014 to 11 573 items (1.49 items/prescriber) in 2020. Methadone (36%,n= 46 660) was the most common controlled opioid prescribed privately, followed by morphine (18%,n= 22 543), buprenorphine (16%,n= 20 521), and oxycodone (12%,n= 15 319). Prescriptions were highest in London (74%,n= 94 438), followed by the South-East of England (7%,n= 9237). A proportion of items (n= 462; 0.36%) were prescribed by ‘unidentified doctors’ where the prescription is not readily attributable to an individual prescriber by the BSA.ConclusionControlled opioids prescribed by private prescribers in England decreased and were primarily prescribed in London. To ensure patient safety, the monitoring and surveillance of controlled opioids dispensed privately should continue and items linked to ‘unidentified doctors’ should be addressed further.
Pengaruh Promosi Desa Wisata Budo Melalui Instagram Terhadap Perilaku Berkunjung Wisatawan Lokal
Authors: Mairi Febri Lestari , Onsu Reiner Richard , Tulung Lingkan E. 
Published: August 2023

Perilaku berkunjung wisatawan dipengaruhi oleh berbagai faktor salah satunya adalah promosi yang dilakukan melalui Instagram, namun minimnya kunjungan dari wisatawan yang disebabkan karena kurang maksimalnya promosi yang dilakukan dan tidak konsisten serta munculnya pandemi covid-19. Penelitian ini bertujuan untuk mengetahui seberapa besar pengaruh promosi desa wisata Budo melalui instagram terhadap perilaku berkunjung wisatawan lokal. Metode penelitian yang digunakan yaitu metode kuantitatif dengan teknik pengumpulan data menggunakan kuesioner. Populasi dalam penelitian ini yaitu followers akun Instagram @desawisata.budo berjumlah 644 (09 Januari 2023) dengan jumlah sampel sebanyak 87 responden, teknik pengambilan sampel yang digunakan yaitu teknik probability sampling dengan pendekatan Simple Random Sampling. Berdasarkan hasil penelitian uji hipotesis (t) didapatkan nilai = 10,430 > nilai = 1,988 maka ditarik kesimpulan terdapat pengaruh positif dan signifikan Promosi Desa Wisata melalui Instagram terhadap Perilaku Berkunjung Wisatawan Lokal. Diperoleh nilai koefisien determinasi atau sebesar 0,561 artinya terdapat pengaruh sebesar 56,1% promosi desa wisata budo (X) terhadap perilaku berkunjung wisatawan lokal (Y).
Peran Diplomasi Anime Dalam Menyebarkan Budaya Jepang Di Indonesia
Authors: Patioran Apriliany P. , Niode Burhan , Rengkung Franky R. D. 
Published: August 2023

Penyebaran budaya Jepang di Indonesia yang kian hari makin meluas merupakan salah satu dampak dari anime Jepang yang masuk ke Indonesia membawa nilai-nilai budaya yang dianut Jepang. Penyebaran budaya Jepang tersebut dapat dilihat dari maraknya event, festival maupun komunitas-komunitas Jejepangan di Indonesia. Hal itu tidak terlepas dari peran pemerintah Jepang sendiri yang sangat mendukung produksi dan peningkatan anime. Berdasarkan hal tersebut, penelitian ini bertujuan untuk mengetahui peran dari diplomasi yang dijalankan pemerintah dalam menyebarkan budaya Jepang melalui anime khususnya di Indonesia. Penelitian ini menggukanan jenis penelitian deskriptif. Data yang digunakan menggunakan data pustaka berbasis dokumen dan internet yang kemudian ditelaah dan ditarik kesimpulan. Analisis data menggunakan teknik analisis data kualitatif. Hasil kajian menunjukkan bahwa anime menjadi salah satu soft power Jepang yang disalurkan melalui diplomasi kebudayaan yang dilakukan di Indonesia, anime yang diproduksi tidak hanya diperuntukkan kepada kalangan anak-anak tetapi juga dikalangan orang dewasa, pemerintah Jepang menggunakan anime sebagai alat untuk melakukan diplomasi dengan memanfaatkan kepopuleran anime menjadi duta pariwisata.

Kata Kunci: Anime; Diplomasi; Budaya; Jepang; Indonesia.

ABSTRACT
The spread of Japanese culture in Indonesia, which is increasingly widespread, is one of the impacts of Japanese anime entering Indonesia bringing the cultural values adopted by Japan. The spread of Japanese culture can be seen from the rampant events, festivals and the Japan communities in Indonesia. This is inseparable from the role of the Japanese government itself which strongly supports the production and improvement of anime. Based on this, this study aims to determine the role of government-run diplomacy in spreading Japanese culture through anime, especially in Indonesia. This research uses a descriptive type of research. The data used uses document-based and internet-based library data which is then reviewed and conclusions drawn. Data analysis uses qualitative data analysis techniques. The results of the study show that anime is one of Japan's soft powers channeled through cultural diplomacy carried out in Indonesia, anime produced are not only intended for children but also among adults, the Japanese government uses anime as a tool to conduct diplomacy by utilizing the popularity of anime to become tourism ambassadors.

Keywords: Anime; Culture; Diplomacy; Indonesian; Japanese
IMPACT OF ZYMOMONAS MOBILIS TREATED CORN COBS ON GROWTH PERFORMANCE, APPARENT NUTRIENT DIGESTIBILITY, ILEAL DIGESTA VISCOSITY AND COST BENEFITS OF BROILER CHICKENS
Authors: ALADE Adelaja Augustine , BAMGBOSE Adeyemi Mustapha , OLANLOYE Silifat Adewunmi , OSO Abimbola Oladele , OKE Oyegunle Emmanuel , FAFIOLU Adeboye Olusesan , SOBAYO Richard Abayomi , ADEWUMI Babatunde Adewale , ANIGBOGU Nnamdi Mbanefo , OLUWATOSIN Oluseyi Oluwajubelo 
Published: August 2023

The fibrous nature of ground corn cobs limited their utilization in poultry production. Zymomonas mobilis derivable from fresh palm sap is proposed to ferment corn cobs to improve their nutritive values. An experiment was carried out to evaluate the effect of ground corn cobs inoculated with Zymomonas mobilis (CCZ) on growth response, apparent nutrient digestibility and ileal digesta viscosity of broiler chickens. Five diets containing treated and untreated corn cobs were formulated to replace wheat offal at 0, 50 and 100 % levels on weight for weight basis. A total of three hundred and seventy-five 1-day-old unsexed Marshall broiler chickens were randomly allotted to the five dietary treatments in a Completely Randomized Design (CRD). Results showed that the biodegradation of corn cobs resulted in improved (p < 0.05) nutrient composition, crude protein increased by 63.90 % while the crude fibre decreased by 137.89 % after fermentation with Zymomonas mobilis. The broiler chickens fed 100 % CCZ had the lowest (p < 0.05) values for feed conversion ratio (FCR) at both phases. The 50 % CCZ improved (p < 0.05) crude fibre digestibility (CFD) at the finisher phase. However, 50 % and 100 % CCZ reduced (p < 0.05) the ileal digesta viscosity of the broiler chickens. The birds fed 100 % CCZ had the highest (p < 0.05) values of rate of return on investment, economic efficiency and relative cost-benefit. The study concluded that wheat offal could be replaced with 50 % and 100 % CCZ in the ration of broiler chickens with positive economic returns.
PENGARUH PENGGUNAAN GADGET TERHADAP HASIL BELAJAR IPS SISWA SDN 13 MUARADUA
Authors: Olvika Sandi Messy , Yasir Arafat  , Eni Heldayani  
Published: August 2023

This study aims to determine the effect of using gadgets on social studies learning outcomes of grade five students of SDN 13 Muardua. The research was carried out in the even semester of 2022/2023. The study used the Experimental method with True Experimental Design techniques in the form of a Pretest-Posttest Control Group Design. The sample in the study was class V-A as a control totaling 29 students, and class V-B as an experimental class totaling 31 students. The research instrument used is a written test in the form of multiple-choice questions as many as 10 questions on the material Location of Geography and Indonesian Astronomy of Natural Appearance (Landscape). Based on the data from the results of the research that has been carried out, it can be proven from the results of the final test (posttest) in the experimental class given treatment using gadgets obtained an average value of 59.03 and the control class obtained an average value of 49.31. In addition, through hypothesis testing with the T-test (Independent Sample T-Test), the results obtained that the calculated value of t-table > is 2.776 > 1.672 which means Ha is accepted and Ho is rejected. So it can be concluded that there is influence of the use of gadgets on the social studies learning outcomes of SD Negeri 13 Muaradua.
Keywords: Gadget Use, Social Studies Learning Outcomes
IMPLEMENTASI EKSTRAKURIKULER PRAMUKA TERHADAP NILAI-NILAI KARAKTER SISWA SD NEGERI KALICARI 01 SEMARANG
Authors: Dian Nur Izzah  , Choirul Huda  , Ikha Listyarini  
Published: August 2023

ABSTRAK
Ekstrakurikuler pramuka adalah pendidikan eksternal yang menggunakan sistem untuk membimbing dan membentuk karakter anggotanya. Kegiatan pramuka dianggap sebagai kegiatan pelengkap dari proses kegiatan belajar di sekolah. Nilai-nilai yang terkandung dalam kepramukaan sangat membantu dalam proses menanamkan karakter kepada anak-anak. Usia anak sekolah dasar sangat tepat untuk meletakkan fondasi bagi pembentukan konsep moralitas dan menumbuhkan nilai karakter di dalamnya. Tujuan dari penelitian ini memberikan informasi dan pengetahuan baru tentang pengembangan nilai-nilai karakter melalui ekstrakurikuler pramuka di SD N Kalicari 01 Semarang. Metode penelitian yang digunakan kualitatif deskriptif. Teknik pengumpulan data yaitu wawancara, observasi dan dokumentasi. Hasil penelitian menunjukan bahwa nilai-nilai karakter siswa berlangsung dengan baik dibuktikan dengan memulai pembiasaan baik yang dilakukan oleh warga sekolah. Ekstrakurikuler Pramuka menerapkan pola bermain sambil belajar yang berguna untuk memperhatikan perkembangan pola pikir siswa dalam menerima pembelajaran dari materi dan tugas yang diberikan kakak Pembina Siaga maupun Penggalang. Jadi, dapat disimpulkan bahwa nilai karakter pramuka dilakukan melalui pembiasaan secara berkelanjutan.
Kata Kunci: Ekstrakurikuler, Pramuka, Nilai Karakter
PENGARUH MODEL PEMBELAJARAN ROLE PLAYING TERHADAP MENGKREASIKAN ISI TEKS FABEL SISWA KELAS VII SMP DAARUL AITAM PALEMBANG
Authors: Ummuh Aisyah  , Dessy Wardiah  , Darwin Effendi  
Published: August 2023

Tujuan penelitian ini adalah untuk mengetahui pengaruh model pembelajaran Role Playing terhadap mengkreasikan isi teks fabel siswa kelas VII SMP Daarul Aitam Palembang. Desain penelitian yang digunakan adalah Posttest-Only Control Design. Populasi dari penelitian ini yaitu seluruh siswa kelas VII SMP Daarul Aitam Palembang yang sebanyak 126 siswa. Sampel penelitian ini menggunakan teknik Simple Random Sampling . Sampel pada penelitian ini dibagi 2 kelompok, yaitu kelompok eksperimen dan kelompok kontrol dimana kelompok eksperimen sebanyak 32 siswa serta kelompok kontrol sebanyak 31 siswa. Hasil dari penelitian yang dilakukan menunjukkan keberhasilan peneliti mampu merencanakan dan menilai pembelajaran memerankan kembali isi teks fabel, dapat dibuktikan dari hasil penilaian guru Bahasa Indonesia mengenai persiapan perencanaan pembelajaran. Peneliti mendapatkan hasil rata-rata sebesar 77,66 dalam merencanakan pembelajaran memerankan kembali isi teks fabel pada kelompok eksperimen dengan menggunakan model pembelajaran Role Playing. Pada kelompok kontrol nilai rata-rata yang di dapat sebesar 64,35. Perbedaan pada kelompok eksperimen dan kelompok kontrol menunjukkan selisih sebesar 13,31. Pada kelompok eksperimen menunjukkan kenormalan data pada nilai Asymp.Sig 0,558 > 0,05 dan kenormalan data pada kelompok kontrol dengan nilai Asymp.Sig 0,361 > 0,05. Teknik analisis data pada riset menggunakan uji Independent Samples Test-Mann Whitney U. Taraf nilai Asymp.Sig (2 Tailed) 0,0 0> 0,05, dapat ditarik kesimpulan bahwa adanya pengaruh yang signifikan pada pemakaian model pembelajran Role Playing terhadap mengkreasikan isi teks fabel siswa kelas VII SMP Daarul Aitam Palembang.
Analiza ekosystemu tożsamości cyfrowej w Polsce, stopnia jego wdrożenia i zastosowanie dowodów osobistych z warstwą elektroniczną
Authors: Wodo Wojciech , Rybak Damian , Błaśkiewicz Przemysław 
Published: August 2023

Harmonizacja wiedzy i procesów związanych z tożsamością elektroniczną w Polsce i Europie jest wyzwaniem z uwagi na ciągłe zmiany legislacyjne i techniczne w tym obszarze, jak również brak ugruntowanych źródeł wiedzy i kampanii edukacyjnych. Temat cyfrowej tożsamości, chociaż dotyczy każdego obywatela, nie jest wystarczająco obecny w debatach publicznych – dlatego zdecydowaliśmy się na zgłębienie tego zagadnienia i zaprezentowanie go jak najszerszemu gronu odbiorców.
Na przestrzeni ostatnich lat powstały różne usługi zaufania, udostępniane publicznie i komercyjnie. Zostały one ze sobą zintegrowane i pozwalają uprościć wiele zadań z zakresu weryfikacji tożsamości, zawierania umów, składania wniosków czy przekazywania danych osobowych.
W książce analizujemy poszczególne elementy składowe ekosystemu usług cyfrowych w Polsce i pokazujemy, jak korzystać z nich efektywnie. Prezentujemy, jak działa i co oferuje nowy dowód osobisty z warstwą elektroniczną (e-dowód), w jaki sposób wykorzystywać podpisy elektroniczne i je łatwo weryfikować, czym jest portfel tożsamości mObywatel i co oferuje oraz jak będzie wyglądać koncepcja europejskiego portfela tożsamości EUDI Wallet.
Survival processing occupies the central bottleneck of cognitive processing: A psychological refractory period analysis
Authors: Kroneisen Meike , Erdfelder Edgar , Groß Rika Maria , Janczyk Markus 
Published: August 2023

AbstractWords judged for relevance in a survival situation are remembered better than words judged for relevance in a nonsurvival context. This survival processing effect has been explained by selective tuning of human memory during evolution to process and retain information specifically relevant for survival. According to the richness-of-encoding hypothesis the survival processing effect arises from a domain-general mechanism—namely, a particularly rich and distinct form of encoding. This form of information processing is effortful and requires limited cognitive capacities. In our experiment, we used the well-established psychological refractory period framework in conjunction with the effect propagation logic to assess the role of central cognitive resources for the survival processing effect. Our data demonstrate that the survival memory advantage indeed relies on the capacity-limited central stage of cognitive processing. Thus, rating words in the context of a survival scenario involves central processing resources to a greater amount than rating words in a nonsurvival control condition. We discuss implications for theories of the survival processing effect.
An annotated nomenclatural checklist of endemic vascular plants distributed in the Ukrainian Carpathians
Authors: Novikov Andriy 
Published: August 2023

The current paper presents a nomenclatural checklist for vascular plants validated being (sub)endemic to and present in the flora of the Ukrainian Carpathians. This checklist is a part of the work targeted on an inventory of endemic plants distributed in the Ukrainian Carpathians. It is mainly based on the analysis of primary sources (i.e. original protologues and monographic works), but also uses the data provided in the recent online taxonomic aggregators, such as the Global Biodiversity Information Facility (GBIF), Catalogue of Life (CoL), Plants of the World Online (POWO), Euro+Med PlantBase, World Flora Online (WFO) and others. Over 7,000 specimens deposited in the leading Ukrainian herbaria were also revised and used as a supporting data source during the work on the checklist.
The checklist provides a revised nomenclature, including corrections on publication dates, rediscovered taxonomic protologues, corrected authorships and revised taxonomic status for (sub)endemic (sub)species of vascular plants occurring in the Ukrainian Carpathians. It contains 1,101 names, from which 78 species and subspecies have been accepted as valid and 1023 species and infraspecific taxa are provided as synonyms. It is completed with critical notes on the nomenclature of problematic taxa and brief annotations regarding their distribution in the Ukrainian Carpathians, indicating the endemicity range and sozological status for all analysed (sub)species.
The current checklist is linked with the GBIF taxonomic backbone, provides notes on detected issues and primarily focuses on its update and correction of the nomenclatural issues and taxonomic inconsistencies, but also aims at discussing issues in other popular taxonomic databases.
Sabulina pauciflora is proposed as a new combination to comply with a recent revision of the genus Sabulina.
End-Stage Idiopathic Pulmonary Fibrosis Lung Microenvironment Promotes Impaired NK Activity
Authors: Cruz Tamara , Agudelo Garcia Paula A , Chamucero-Millares Julián A , Bondonese Anna , Mitash Nilay , Sembrat John , Tabib Tracy , Zhang Wenping , Seyed Nouraie , Peters Victor , Stacey Sean , Vignali Dario , Mora Ana L , Lafyatis Robert , Rojas Mauricio 
Published: August 2023

Abstract
Idiopathic pulmonary fibrosis (IPF) is a fibrotic age-related chronic lung disease characterized by the accumulation of senescent cells. Whether impaired immune response is responsible for the accumulation of senescent cells in the IPF lung remains unknown. In this study, we characterized the NK phenotype in IPF lungs via flow cytometry using 5-dodecanoylaminofluorescein di-β-d-galactopyranoside, markers of tissue residence, and chemokine receptors. The effect of the lung microenvironment was evaluated using lung fibroblast (LF) conditioned media (CM), and the bleomycin-induced pulmonary fibrosis mouse model was used to assess the in vivo relationship between NK cells and the accumulation of senescent cells. We found that NK cells from the lower lobe of IPF patients exhibited immune-senescent and impaired CD57−NKG2A+ phenotype. We also observed that culture of NK cells from healthy donors in CM from IPF lower lobe lung fibroblasts induced a senescent-like phenotype and impaired cytotoxic capacity. There is an impaired NK recruitment by LF, and NKs presented decreased migration toward their CM. In addition, NK cell–depleted mice treated with bleomycin showed increased collagen deposition and accumulation of different populations of senescent cells compared with controls. The IPF lung microenvironment induces a dysfunctional NK phenotype limiting the clearance of lung senescent cells and the resolution of lung fibrosis. We propose that impaired NK activity could be one of the mechanisms responsible for perpetuating the accumulation of senescent cells in IPF lungs.
That they may be one (Jn 17:11): Mending the seamless coat of Christ in Assemblies of God Nigeria
Authors: Ituma Ezichi A. , Ogbu Kalu O. , Peters Prince E. 
Published: August 2023

Assemblies of God church in Nigeria, which has for over 40 years now, experienced various crises that have led to sucession and factionalism in that church. The once giant of spirituality and the mother of Pentecostalism has grappled with the problem of administration, leadership tussle and bigotry. This study is a review of previous and current crises that AG Nigeria has gone through at the General Council level in a bid to mend what seems to have torn asunder the seamless coat of Christ in line with the prayer of Jesus, ‘that they may be one’. The study uses historical-critical method and phenomenological design to analyse the depth of the crack in the church in order to predict the future of Pentecostalism in Nigeria.Contribution: To chronicle the crises in Assemblies of God Nigeria through a study of current and past patterns of events with a view to recommending possible solutions.