bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chaves do êxito do Turismo em Espaço Rural (TER): evidências a partir da lealdade turística na Rede das Aldeias do Xisto
Authors: Martínez-Roget Fidel , Tavares Moutela José Alberto , Estévez Núñez Juan Carlos 
Published: March 2023

de forma assinalável nos últimos anos, ancorado por fatores que incidiram tanto na oferta como na procura. Pelo lado da oferta, muitos territórios rurais apostaram no TER como alternativa para atenuar os seus múltiplos problemas. Pelo lado da procura, um importante e crescente número de pessoas começaram a procurar modelos turísticos em contato com a natureza, em ambientes rurais, relaxantes e tranquilos. Num contexto tão competitivo como é o atual, o êxito dos destinos rurais vai depender, em grande medida, da lealdade turística. Neste trabalho analisa-se a lealdade dos turistas portugueses que visitaram uma ou mais das “Aldeias do Xisto” no Centro de Portugal, bem como as relações com a motivação e com a satisfação turística. Os resultados deveriam servir de ajuda para a tomada de decisões e para o desenho de estratégias de marketing efetivas no meio rural.
Pressão Demográfica Sobre o Recurso Hídrico e a Sua Relação Com a Sustentabilidade dos Destinos Turísticos. Uma Análise Para o Sul do Equador
Authors: Massa-Sánchez Priscilla , Arteaga-Marín Juan , Viñán-Merecí Christian , Martínez-Fernández Valentín-Alejandro 
Published: March 2023

El objeto de este trabajo consiste en determinar el rol de la presión demográfica sobre el recurso hídrico y su relación con el desarrollo turístico, esto se expresa a través de un índice de presión demográfica sobre el agua. La investigación se llevó a cabo en la provincia de Loja (Sudamérica, Ecuador). Los resultados indican que la mayor presión demográfica sobre el agua se concentra en un área muy pequeña, al representar el 2.5% del territorio, y aproximadamente la mitad del mismo tiene problemas de presión sobre el recurso hídrico. Estos resultados responden principalmente a la alta con centración poblacional relativa en estas zonas, y a los factores hidrológicos y climáticos característicos que condicionan la cantidad de agua disponible y con ello el desarrollo turístico principalmente de los cantones fronterizos.
Insuficiencia cardíaca congestiva: evolución clínica, enfermedades relacionadas - Informe de caso
Authors: Balzan Gabriela , Rodrigues Adevanil Santos , Malaggi Vitoria Baltazar , Bortolanza Matheus de Castro , Dos Santos Joemylle Brito , Llorente Milko 
Published: March 2023

Introducción
La Insuficiencia Cardiaca Congestiva (ICC) es un síndrome de disfunción ventricular que ocurre cuando el corazón no bombea suficiente sangre para satisfacer las necesidades del cuerpo. Como resultado, el líquido se acumula en los miembros inferiores, en los pulmones y otros tejidos, lo que lleva al paciente a experimentar una serie de síntomas como: disnea, edema de miembros inferiores, ortopnea y otros en grados más avanzados. Las principales etiologías de la ICC incluyen: hipertensión arterial, enfermedad arterial coronaria, etc.
Este trabajo de investigación tiene por finalidad informar un caso; además, comprender su proceso fisiopatológico, tratamiento, acompañar la evolución del paciente y buscar maneras de mejorar la calidad de vida de este.
El estudio adopta un enfoque cualitativo, describiendo experiencias adquiridas y observadas durante consultas y el monitoreo en la Clínica.
Informe de caso
Paciente M.V., sexo masculino, de 68 años, llega al consultorio para su examen de rutina, informa ser diabético e hipertenso hace más de 30 años. Durante el examen físico estaba taquicárdico, disneico, dedo de los pies cianóticos, edema en miembros inferiores con fóvea de Godet positiva (+++/+). En aparato cardiovascular: precordio normal, ritmo cardíaco irregular con presencia de R3, soplo en foco mitral, pulsos arteriales asimétricos en baja amplitud. Al examen físico del abdomen se constata abdomen globuloso a expensas de tejido adiposo, no doloroso a la palpación superficial y profunda, RHA: +.
PA: 140/80 mmhg, FC: 94 lpm, SPO2: 97%, HGT: 181 mg/dL. Medicamentos de uso: Amiodarona y Digoxina. En tratamiento continuo con su cardiólogo.
Discusión
Durante el estudio observamos que, en la terapia antihipertensiva con IECA (enalapril) de larga duración, el paciente tuvo un beneficio significativo, mostrando una mejoría en los síntomas de ICC. A pesar del control exitoso del edema, persisten las anomalías hemodinámicas que limitan la capacidad del sujeto para hacer ejercicio y realizar actividades de la vida diaria.
Conclusión
La incidencia de ICC es directamente proporcional a la edad, siendo la principal causa de hospitalización en los mayores de 65 años y considerado un importante problema de Salud Pública; además, de limitar la calidad de vida del paciente. Por lo tanto, el diagnóstico temprano y el tratamiento adecuado para la insuficiencia cardíaca congestiva son importantes para minimizar sus daños.
Pembelajaran Akuntansi Secara Online: Pengujian Model Unified Theory Of Acceptance Dan Use Of Technology (UTAUT)
Authors: Elsha Nadia , Atikah Siti , Lenap Indri Pupitasari 
Published: March 2023

This study aims to test and analyze the factors that affect the E-learning System at the Faculty of Economics and Business, University of Mataram. The unified theory of acceptance and use of technology (UTAUT) model is a synthesis of a technological acceptance model that will be appropriately used as an e-learning evaluation model. The variables used in this study are the four key constructs of UTAUT, namely; performance expectancy, effort expectancy, social influence, and facilitating condition. The samples in this study were determined using purposive sampling and determination of the number of samples using the Yamane taro technique so that a total sample of 229 respondents was obtained. Data collection was carried out by the questionnaire method and used SPSS version 25 in carrying out statistical data analysis. The results of this proposal show that the variables of performance expectancy, effort expectancy, and social influence do not have a significant effect on the e-larning system, while the facilitating condition variables have a significant effect on the e-learning system.
Keyword: E-learning system, acceptance, UTAUT mode
La variabilité intra-individuelle du mouvement en performance pianistique. Une revue exploratoire
Authors: Séguin Nicholas , Comeau Gilles 
Published: March 2023

Lorsqu’un mouvement est répété à plusieurs reprises, de subtiles différences peuvent être observées entre les répétitions. En biomécanique sportive, l’étude de la variabilité intra-individuelle (vi) du mouvement et de ses implications a le potentiel de prévenir les blessures, d’évaluer le progrès de traitements et d’informer le développement de protocoles de recherche (Preatoni et al. 2013). Bien que les chercheurs du domaine de la musique partagent plusieurs de ces objectifs, peu d’attention a été accordée à la vi du mouvement. Cette revue exploratoire vise à consolider les informations existantes concernant la vi du mouvement en performance pianistique afin d’explorer trois importants enjeux méthodologiques : a) quelles méthodes ont été utilisées pour mesurer cette vi du mouvement ; b) quelle est l’influence de l’expertise sur cette vi du mouvement et c) combien d’essais devraient être utilisés dans un protocole de recherche afin d’obtenir une évaluation fiable d’une performance. En outre, les lacunes dans notre compréhension du phénomène sont identifiées et des recommandations pour les recherches futures sont émises.
RNA-seq reveals Nup62 as a potential regulator for cell division after traumatic brain injury in mice hippocampus
Authors: Zhao Jianwei , Wang Weihua , Yan Ke , Zhao Haifeng , Zhang Zhen , Wang Yu , Zhu Wenyu , Chen Shiwen 
Published: March 2023

Background
Hippocampus impairment is a common condition encountered in the clinical diagnosis and treatment of traumatic brain injury (TBI). Several studies have investigated this phenomenon. However, its molecular mechanism remains unclear.

Methods
In this study, Illumina RNA-seq technology was used to determine the gene expression profile in mice hippocampus after TBI. We then conducted bioinformatics analysis to identify the altered gene expression signatures and mechanisms related to TBI-induced pathology in the hippocampus. Real-time quantitative polymerase chain reaction and western blot were adopted to verify the sequencing results.

Results
The controlled cortical impact was adopted as the TBI model. Hippocampal specimens were removed for sequencing. Bioinformatics analysis identified 27 upregulated and 17 downregulated differentially expressed genes (DEGs) in post-TBI mouse models. Potential biological functions of the genes were determined via Gene Set Enrichment Analysis (GSEA)-based Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses, which suggested a series of functional changes in the nervous system. Specifically, the nucleoporin 62 (Nup62) DEG was discussed and verified. Gene ontology biological process enriched analysis suggests that the cell division was upregulated significantly. The present study may be helpful for the treatment of impaired hippocampus after TBI in the future.
Visual atrophy rating scales and amyloid PET status in an Alzheimer's disease clinical cohort
Authors: Loreto Flavia , Gontsarova Anastassia , Scott Gregory , Patel Neva , Win Zarni , Carswell Christopher , Perry Richard , Malhotra Paresh 
Published: March 2023

AbstractObjectivesVisual rating scales (VRS) are the quantification method closest to the approach used in routine clinical practice to assess brain atrophy. Previous studies have suggested that the medial temporal atrophy (MTA) rating scale is a reliable diagnostic marker for AD, equivalent to volumetric quantification, while others propose a higher diagnostic utility for the Posterior Atrophy (PA) scale in early‐onset AD.MethodsHere, we reviewed 14 studies that assessed the diagnostic accuracy of PA and MTA, we explored the issue of cut‐off heterogeneity, and assessed 9 rating scales in a group of patients with biomarker‐confirmed diagnosis. A neuroradiologist blinded to all clinical information rated the MR images of 39 amyloid‐positive and 38 amyloid‐negative patients using 9 validated VRS assessing multiple brain regions. Automated volumetric analyses were performed on a subset of patients (n = 48) and on a group of cognitively normal individuals (n = 28).ResultsNo single VRS could differentiate amyloid‐positive from amyloid‐negative patients with other neurodegenerative conditions. 44% of amyloid‐positive patients were deemed to have age‐appropriate levels of MTA. In the amyloid‐positive group, 18% had no abnormal MTA or PA scores. These findings were substantially affected by cut‐off selection. Amyloid‐positive and amyloid‐negative patients had comparable hippocampal and parietal volumes, and MTA but not PA scores correlated with the respective volumetric measures.InterpretationConsensus guidelines are needed before VRS can be recommended for use in the diagnostic workup of AD. Our data are suggestive of high intragroup variability and non‐superiority of volumetric quantification of atrophy over visual assessment.
Analytic thinking as revealed by function words: What does language really measure?
Authors: Markowitz David M. 
Published: March 2023

AbstractUnderstanding how people think is a key interest in psychology, and recent advances in automated text analysis have used a verbal analytic thinking index to approximate Kahneman's System 2 (e.g., deliberate, rational thinking). That is, prior work used a style word index to assess university student admissions essays and observed that those who used more articles and prepositions relative to storytelling words (e.g., pronouns) had higher grades at the end of college. This work presumed that verbal analytic thinking represented one's cognitive ability or intellectual potential, but this presumption has remained untested. The current research evaluated if verbal analytic thinking is indeed a reflection of cognitive ability or one's interest and motivation to engage in thinking, called need for cognition. Across 500 participants and two writing samples, the most reliable link to verbal analytic thinking was need for cognition, addressing an unexamined empirical question in psychology of language research.
Recent Advances in Electron Donor‐Acceptor (EDA)‐Complex Reactions involving Quaternary Pyridinium Derivatives
Authors: Saxena Barakha , Patel Roshan I. , Sharma Anuj 
Published: March 2023

AbstractQuaternary pyridinium compounds are valuable intermediates in organic synthesis, which have gained immense popularity in the synthetic community. The application of transition metal or photoredox catalysis in transforming quaternary pyridinium compounds into various C−C and C−X bonds is well established. A majority of these methods require high temperatures, expansive catalysts, and delicate conditions for successful execution. On the other hand, the use of transition metal‐free and photocatalysis‐free strategies in constructing C−C and C−X bonds using quaternary pyridinium derivatives has been sought‐after. In this context, the electron‐donor‐acceptor (EDA)‐complex reactions have emerged as a state‐of‐the‐art organic synthetic methodology, which do not require any photocatalyst for their successful execution. EDA‐complex photochemistry takes advantage of the electron‐acceptor ability of quaternary pyridinium derivatives, which can quickly generate a radical precursor via the deaminative process. These newly generated radical intermediates are useful in several valuable transformations. We hereby, in this review, discuss an area of major progress in EDA‐complex mediated reactions involving quaternary pyridinium compounds with mechanism, substrate scope, and limitations.magnified image
Predicting factors of neurodevelopmental performance in children with phenylketonuria
Authors: Azevedo Soares Célia , Ferreira Almeida Manuela , Soares Gabriela , Tkachenko Natália , Fortuna Ana Maria , Carmona Carla 
Published: March 2023

AbstractIn phenylketonuria (PKU), high phenylalanine (Phe) levels hamper neurodevelopment impairing executive function later in life. While the second has been more studied, fewer data exist on predictors of PKU patients' development in specific populations. To contribute to the field, we performed a retrospective analysis of predictors of neurodevelopment in PKU patients in a Portuguese cohort. We analyzed the retrospective data on the metabolic control of 89 patients, as their health and familial features. Griffith's Mental Development Scale performance at age 6 (GMDS6) was used to assess neurodevelopment. Our cohort included 14 GMDS6low and 75 GMDS6high patients. In a multivariate analysis, the better predictors of neurodevelopment were the metabolic control at age 3 and year of birth (n = 87, β0 = −121, β1 = −1.77, β2 = 0.06, LRchi2(2) = 13.61, Prob > chi2 = 0.001, Pseudo R2 = 0.1773). With this model, it was possible to define a safety cut‐off of 7.8 mg/dL for the Phe level at age 3 (sensitivity = 72.6%, specificity = 78.6%), confirming the safety of the cut‐off of 6 mg/dL already used in the clinical practice. Our study supports the relevance of metabolic control to predict the neurodevelopment of PKU patients, in the historical context of the disease management.
Selektive Darstellung von Phosphormononitrid (P≡N) aus Phosphinazid und Reversible Oxidation zu Phosphinnitren
Authors: Qian Weiyu , Wende Raffael C. , Schreiner Peter R. , Mardyukov Artur 
Published: March 2023

AbstractDas potentiell interstellare Molekül Phosphormononitrid, eine metastabile Spezies, wurde durch Hochvakuum‐Blitzpyrolyse ausgehend von (o‐Phenyldioxyl)phosphinazid in kryogenen Matrizes generiert. Obwohl die PN‐Streckschwingungsbande aufgrund ihrer geringen Infrarotintensität und durch mögliche Überlagerungen mit stärkeren Banden nicht direkt detektiert wurde, konnten o‐Benzochinon, Kohlenstoffmonoxid und Cyclopentadienon als zusätzliche Fragmentierungsprodukte eindeutig identifiziert werden. Darüber hinaus bildete sich ein schwer fassbarer o‐Benzochinon‐PN‐Komplex wenn (o‐Phenyldioxyl)phosphinazid UV‐Strahlung mit λ=254 nm ausgesetzt wurde. Die Rekombination zu (o‐Phenyldioxyl)‐λ5‐phosphinnitril wurde bei Bestrahlung mit Licht mit λ=523 nm beobachtet. Dies demonstriert zum ersten Mal die Reaktivität von PN mit einem organischen Molekül. Berechnungen der Energieprofile auf dem B3LYP/def2‐TZVP Dichtefunktionaltheorie‐Niveau zeigen einen konzertierten Mechanismus. Zum weiteren Nachweis wurden UV/Vis‐Spektren des Vorläufers und der Bestrahlungsprodukte aufgenommen, die gut mit zeitabhängigen DFT‐Berechnungen übereinstimmen.
Facile Synthesis of an Octagermacubane with Two Three‐Coordinate Germanium(0) Atoms and its Unique Radical Anion
Authors: Bashkurov Roman , Kaushansky Alexander , Tumanskii Boris , Fridman Natalia , Bravo‐Zhivotovskii Dmitry , Apeloig Yitzhak 
Published: March 2023

AbstractThermolysis of a 1 : 1 mixture of tris(di‐tert‐butylmethylsilyl)germane 9 and bis(di‐tert‐butylmethylsilyl)germane 17 at 100 °C produces unexpectedly octagermacubane 18, having two 3‐coordinate Ge0 atoms (40 % yield). 18 was characterized by X‐ray crystallography and it is a singlet biradical (according to DFT quantum mechanical calculations and the absence of an EPR signal). Reactions of 18 with CH2Cl2 and H2O yield the novel dichloro‐octagermacubane 24 and hydroxy‐octagermacubane 25, respectively. Reduction of 18 with tBuMe2SiNa in THF produces an isolable octagermacubane radical anion 26‐Na. Based on X‐ray crystallography, EPR spectroscopy and DFT quantum mechanical calculations, 26‐Na is classified as a Ge‐centered radical anion.
Red Emissive Double Aza[7]helicenes with Antiaromaticity / Aromaticity Switching via the Redox‐Induced Radical Cation and Dication Species
Authors: Li Chenglong , Zhang Chen , Li Pengfei , Jia Yawei , Duan Jiaxian , Liu Meiyan , Zhang Niu , Chen Pangkuan 
Published: March 2023

AbstractWe herein present the synthetic approach to a new antiaromatic double aza[7]heliceneCthat features NN‐embedded polycyclic aromatic hydrocarbons (PAHs). This heteroatom‐doped helicene showed a rarely obtained long‐wavelength emission and far‐red circularly polarized luminescence (CPL) in the solid state. These optical and chiroptical properties could be ascribed to both the NN‐PAH core structure and the further extension through angular ring fusions. Such a unique electronic structure also culminated in facile chemical oxidations of neutralCto the positively charged chiral radical (C⋅+) and dication species (C2+). Interestingly, DFT computations revealed that the pyridazine central core showed an antiaromaticity‐to‐aromaticity switching, in contrast to the inversed transition for the helical periphery in cationic states. The reported approaches are anticipated to lead to the development of further redox‐active chiral systems for potential applications in chiroptoelectronics, spintronics as well as fluorescent bioimaging.
Multimodal Analysis of Light‐Driven Water Oxidation in Nanoporous Block Copolymer Membranes**
Authors: Kund Julian , Kruse Jan‐Hendrik , Gruber Andreas , Trentin Ivan , Langer Marcel , Read Clarissa , Neusser Gregor , Blaimer Dominik , Rupp Ulrich , Streb Carsten , Leopold Kerstin , Schacher Felix H. , Kranz Christine 
Published: March 2023

AbstractHeterogeneous light‐driven catalysis is a cornerstone of sustainable energy conversion. Most catalytic studies focus on bulk analyses of the hydrogen and oxygen evolved, which impede the correlation of matrix heterogeneities, molecular features, and bulk reactivity. Here, we report studies of a heterogenized catalyst/photosensitizer system using a polyoxometalate water oxidation catalyst and a model, molecular photosensitizer that were co‐immobilized within a nanoporous block copolymer membrane. Via operando scanning electrochemical microscopy (SECM), light‐induced oxygen evolution was determined using sodium peroxodisulfate (Na2S2O8) as sacrificial electron acceptor. Ex situ element analyses provided spatially resolved information on the local concentration and distribution of the molecular components. Infrared attenuated total reflection (IR‐ATR) studies of the modified membranes showed no degradation of the water oxidation catalyst under the reported light‐driven conditions.
Modular Synthesis of Structurally Diverse Azulene‐Embedded Polycyclic Aromatic Hydrocarbons by Knoevenagel‐Type Condensation
Authors: Liu Renxiang , Fu Yubin , Wu Fupeng , Liu Fupin , Zhang Jin‐Jiang , Yang Lin , Popov Alexey A. , Ma Ji , Feng Xinliang 
Published: March 2023

AbstractThe research interest in azulene‐embedded polycyclic aromatic hydrocarbons (PAHs) has significantly increased recently, but the lack of efficient synthetic strategies impedes the investigation of their structure‐property relationships and further opto‐electronic applications. Here we report a modular synthetic strategy towards diverse azulene‐embedded PAHs by a tandem Suzuki coupling and base‐promoted Knoevenagel‐type condensation with good yields and great structural versatility, including non‐alternant thiophene‐rich PAHs, butterfly‐ or Z‐shaped PAHs bearing two azulene units, and the first example of a two‐azulene‐embedded double [5]helicene. The structural topology, aromaticity and photophysical properties were investigated by NMR, X‐ray crystallography analysis and UV/Vis absorption spectroscopy assisted by DFT calculations. This strategy provides a new platform for rapidly synthesizing unexplored non‐alternant PAHs or even graphene nanoribbons with multiple azulene units.
Engineering Flexible Metal‐Phenolic Networks with Guest Responsiveness via Intermolecular Interactions
Authors: Xu Wanjun , Pan Shuaijun , Noble Benjamin B. , Lin Zhixing , Kaur Bhangu Sukhvir , Kim Chan‐Jin , Chen Jingqu , Han Yiyuan , Yarovsky Irene , Caruso Frank 
Published: March 2023

AbstractFlexible metal‐organic materials are of growing interest owing to their ability to undergo reversible structural transformations under external stimuli. Here, we report flexible metal‐phenolic networks (MPNs) featuring stimuli‐responsive behavior to diverse solute guests. The competitive coordination of metal ions to phenolic ligands of multiple coordination sites and solute guests (e.g., glucose) primarily determines the responsive behavior of the MPNs, as revealed experimentally and computationally. Glucose molecules can be embedded into the dynamic MPNs upon mixing, leading to the reconfiguration of the metal‐organic networks and thus changes in their physicochemical properties for targeting applications. This study expands the library of stimuli‐responsive flexible metal‐organic materials and the understanding of intermolecular interactions between metal‐organic materials and solute guests, which is essential for the rational design of responsive materials for various applications.
Understanding Water Age in Distribution Systems withEPANET
Authors: Burkhart Ben , Janke Robert 
Published: March 2023

Key TakeawaysModeling water age is a simple approach, by means of a readily measurable parameter, to rapidly assess a water distribution system's (WDS's) general water quality.Used correctly, the US Environmental Protection Agency's EPANET program can model water age with accuracy, and the results can help in designing, improving, or operating a WDS.The newest edition of EPANET added mass balance calculations and has improved computational time, mass balance performance, and overall model stability.
Washington Dam Project Supports Water and Aquatic Systems
Authors: Marcantonio Marc , Keown Thomas 
Published: March 2023

Key TakeawaysWith increasing pressure on water reliability in Washington's South Puget Sound, helping aquatic species thrive also helps community water resilience—a whale of an idea.Better strategic problem‐solving starts with the transformative idea that is it is not mutually exclusive to ensure water supplies for people and for natural settings.By seeking to gain bipartisan support, financial and permitting hurdles of a complex problem can be overcome to create a win–win for all.