bluuebunny/crossref_metadata_2025_split huggingface dataset:
Jens Haven (1724–1796) and Captain James Cook (1728–1779) in Newfoundland
Authors: Rollmann Hans J. 
Published: April 2023

ABSTRACT
Jens Haven, a former missionary to Green-land, established contact with Inuit from Labrador in 1764. Governor Palliser of Newfoundland saw in Haven’s missionary efforts an opportunity to improve the hitherto hostile relations between the English and Inuit. On his exploration journey, Haven met Captain James Cook near Quirpon on Newfoundland’s Great Northern Peninsula and stayed on his ship. Governor Palliser’s recommendation of Jens Haven to English naval officers in Newfoundland and Labrador provides the context for Haven’s dealings with Captain James Cook. Haven sought to demonstrate throughout the journey his British loyalty. He also found confirmation for an ethnic kinship between Inuit in Labrador and Greenland. The missionary’s relations with Captain Cook are explored here fully by considering all extant archival materials available for the trip, including the German records that he kept from British authorities as well as a later reflection about the trip in 1784.
Uma única aplicação de anticoncepcional produz alterações histológicas no útero de gatas hígidas
Authors: Assis Maisa Martins Quirilos , Sala Pollyana Linhares , Blanca William Torres , Marangon Willian Fontini , Beletini Salviano Tramontin , Quessada Ana Maria 
Published: April 2023

Objetivou-se avaliar efeitos da primeira e única dose de progestágenos em fêmeas felinas hígidas. Selecionaram-se quinze gatas que foram examinadas clinicamente e por exames complementares. Divididas em dois grupos, um (GANT) composto de sete gatas foi aplicado medroxiprogesterona por via subcutânea, obedecendo-se as indicações do fabricante. Outro (GC, controle) composto por oito, que receberam solução fisiológica (1ml) por via subcutânea. Noventa dias após, tais exames foram novamente realizados e foram realizadas as esterilizações cirúrgicas, sendo os tecidos reprodutivos removidos e encaminhados para a realização de histopatologia. Aos 90 dias, foi possível verificar que quatro gatas do GANT apresentaram hiperplasia endometrial cística (HEC) no exame microscópico com diferença estatística significativa. No GC nenhuma gata apresentou alteração. A HEC é a primeira fase da piometra. Foi possível concluir que uma única aplicação de progestágeno em fêmeas hígidas pode causar complicações uterinas. Permitindo afirmar que a administração destes fármacos seja realizada exclusivamente sob orientação de um médico-veterinário, minimizando chances de complicações.
Beauty of Water Movement in Leonardo's Paintings in Renaissance
Authors: Zhang Haoyun 
Published: April 2023

Tracing back to the period between the 14th century and to the 17th century, the Renaissance was started in Italy, with the essence of humanism, which means the reverence for the Greek and Roman culture. Leonardo Da Vinci tends to be the originator of the theory of waves. This article focuses on Leonardo Da Vinci's fluid flow-related work and thought, as well as the beauty of the spiral, as exhibited in his notebooks, letters, and artwork. From the standpoint of water whirlpools, pigtail patterns, and Leonardo Da Vinci's cardiovascular research, using analogies, case analysis, and literature analysis, the beauty of the Renaissance's blending of science and art could be demonstrated. In addition, from the perspective of the values or contributions that Leonardo Da Vinci left behind, the emphasis may be placed on the reverence and awe that Leonardo bestowed upon life, and from the case studies of Golden Horn in Istanbul and The Chateau de Chambord that Leonardo proposed, the cultural heritage's aesthetic value as well as architecture value could be recognized and fully protected.
Preface: 2nd International Conference on Biotechnology, Life Science and Medical Engineering (BLSME 2023)
Authors: Zhang Qi , Bronte Sharon 
Published: April 2023

This conference proceedings volume contains the written versions of the contributions presented during the 2023 2nd International Conference on Biotechnology, Life Science and Medical Engineering (BLSME 2023), it had been held in Jeju, South Korea on March 11-12, 2023. This conference is the premier forum for the presentation of new advances and research results in the fields of biotechnology, bioengineering, biochemistry, preclinical medicine, clinical medicine, pharmacology, life science, medical engineering, and medicine technology.
The conference provided a forum for discussion and sharing between lecturers, researchers, academics, practitioners, communities, and specialists, from universities, research institutes, corporations, industries, the government, and the public. The conference has been a great opportunity for participants coming from many countries to present and discuss topics in their respective research areas.
BLSME 2023 conference included 4 plenary sessions and invited speakers, and oral and poster presentations to allow as many as possible attendances to present their scientific results on the different fields. The manuscripts which have presented were published under the peer-reviewed process.
We would love to express our gratitude for all the participants, keynote speakers, and guests of honor, for their effective contribution in our conference. Our ongoing thankfulness is presented for our guest editors and speakers. Finally, we would love to express our gratefulness for all our sponsors, partners, and colleagues, we hope to collaborate with them in future activities.
Chairman of Conference Committee
Jeju, South Korea
Expression Of Hippo-YAP Signaling Pathway in Gynecological Tumors
Authors: Mo Yunxiang 
Published: April 2023

Ovarian cancer, breast cancer and cervical cancer are common female malignant tumors. YAP signal is widely activated in human malignant tumors. Hippo-YAP signal pathway affects the proliferation and development of tumors. However, the transmission mechanism of YAP signal in gynecological malignant tumors is still unclear. The function of YAP in the Hippo signal route is examined in this research, along with its functions upstream, middle, and downstream of the Hippo signal route. In addition, the mRNA expression data of YAP in ovarian serous cystadenocarcinoma and normal ovarian tissue is compared. The expression of YAP in breast invasive carcinoma (BRCA) is observed by IHC, and the YAP intensity of cytoplasm and nucleus is evaluated. Through the relationship between YAP and HPV, to further investigate the mechanism of YAP in cervical cancer, the distribution of YAP1 in cells adhering to the cervical surface was studied. These findings are critical in the treatment of YAP as a potential therapeutic target. Furthermore, understanding the role of YAP in female malignant tumors provide an insight in developing drugs that block the activity of YAP or inhibit the activation of YAP, they can play an anti-tumor role in vivo.
Technologies and Methods of Patriotic Education in Higher Education Institutions of China
Authors: Gao Yuan 
Published: April 2023

Patriotism, an important component of the Chinese national spirit, has inspired generations of Chinese to strive for national prosperity. If the youth is robust, the country will be strong. Because college students are the vital force of the country and the hope of the nation, it is especially important to cultivate their patriotism. China is facing new challenges, with profound changes in domestic and foreign situations, rapid technological development and increasingly frequent Internet exchanges. The patriotic education environment has also become more complex under the impact of undesirable Western culture. With the external and internal influences, further patriotic education for college students still faces many challenges. We should face up to the problems in contemporary patriotism education in higher education institutions, explore the solutions and cultivate patriotism among college students in the new era. Therefore, the study of patriotism education in higher education institutions has important theoretical and practical significance. This paper mainly analyzes the problems and causes of patriotism education in higher education institutions with contemporary society, college and family education as well as the characteristics of college students themselves, and puts forward targeted countermeasures for solutions. In the main body, this paper is divided into four parts. First of all, there is an introduction, which mainly includes the background and significance of research, the current status of domestic and international research, research methods, innovations and deficiencies. The framework of the paper was determined to be based on relevant domestic and international studies and the theory was well prepared for the article. The second part mainly elaborates the theories and necessity of patriotism education for college students, mainly including the connotation and characteristics of patriotism education. The third part presents a comprehensive analysis of the problem of patriotic education of college students and its causes from the social environment, patriotic education in higher education institutions, family education and college students themselves. The fourth part is the core of this paper, the practical effect of patriotic education in higher education institutions is ensured, by summarizing the relevant theories and proposing effective technologies and methods against the corresponding problems.
Direitos autorais em narrativas transmidiáticas: a instrumentalização do direito do autor nos contratos
Authors: Siteneski do Amaral Jordana , Oro Boff Salete 
Published: April 2023

Neste artigo pretende-se responder ao problema de pesquisa analisando como os Direitos Autorais podem ser assegurados e instrumentalizados em narrativas transmidiáticas. Logo, resume-se o problema de pesquisa em verificar se os contratos são meios válidos para a instrumentalização dos Direitos Autorais em obras construídas por meio de narrativas transmidiáticas. Uma narrativa transmídia é caracterizada pela utilização de várias mídias, com conteúdos diversificados e adaptados para cada tipo de suporte, que formam um amálgama e se complementam mutuamente dando origem a uma nova forma de construir narrativas. Pelo estudo realizado, confirmou-se a hipótese inicial, visto que o autor é livre para dispor e negociar os direitos que lhes são exclusivos de exploração econômica da obra. O autor, por ele mesmo ou por alguma entidade que o represente, pode negociar a abrangência da cessão ou autorização do uso dos direitos patrimoniais que lhe cabem, tais como a finalidade, prazos e qual a onerosidade. Em uma narrativa transmídia é preciso que o instrumento contratual seja minucioso e traga de forma expressa todas as formas de utilização da obra. O método de abordagem utilizado foi o hipotético-dedutivo e o de procedimento monográfico.
Profil Kasus Rawat Inap Bangsal Bedah BLUD RSUD Scholoo Keyen Papua Barat, Indonesia, Januari–Desember 2021
Authors: Harsono  , Wardhana  
Published: April 2023

Tindakan bedah merupakan salah satu intervensi perawatan yang penting. Pusat kesehatan yang telah mengetahui tingkat kejadian kasus bedah spesifik dapat melakukan persiapan dengan lebih baik. Tujuan: Mendapatkan profil kasus rawat inap pasien di bangsal Bedah RSUD Scholoo Keyen Papua Barat, Indonesia, periode Januari–Desember 2021. Metode: Penelitian deskriptif retrospektif. Hasil: Selama periode tersebut didapatkan 206 pasien. Laki-laki sebanyak 60,68%, di mana 27,18% berusia 26-35 tahun, 70,39% merupakan kasus non-trauma, dan 93,69% menjalani tindakan operatif dengan sebagian besar lama perawatan 1-3 hari (71,84%). Tiga kasus terbanyak ialah apendisitis akut (18,45%), abses (14,08%), dan tumor jinak (13,11%). Simpulan: Pada studi ini, mayoritas pasien adalah laki-laki, usia 26-35 tahun, kasus non-trauma operatif terbanyak apendisitis akut dengan lama perawatan 1-3 hari.

Surgery is an important care intervention. Health centers with data on the incidence of specific surgical cases can be better prepared. Objective: To obtain profiles of surgical cases from January to December 2021 at Scholoo Keyen General Hospital, West Papua, Indonesia. Method: A retrospective descriptive survey. Results: During the period, 206 patients were registered. Patients were predominantly male (60,68%), aged 26- 35 years (27,18%), non-traumatic cases (70,39%). Surgery was done in 93,69% of cases within 1-3 days of treatment (71,84%). Three major cases were: acute appendicitis (18,45%), abscess (14,08%), and benign tumor (13,11%). Conclusion: The majority of cases were males, aged 26-35 years, non-traumatic surgical cases with 1-3 day length of treatment; the most frequent case was acute appendicitis.
Diagnosis dan Tata Laksana Capsulitis Adhesiva
Authors: Suhendro Amelia Puspita 
Published: April 2023

Capsulitis adhesiva atau frozen shoulder merupakan gangguan sendi bahu akibat proses peradangan lapisan kapsular sendi glenohumeral yang menyebabkan kekakuan dan nyeri. Kondisi ini relatif umum. Diagnosis melalui anamnesis, pemeriksaan fisik, dan pemeriksaan penunjang. Tatalaksana dilakukan secara non-operatif dan operatif.

Adhesive capsulitis or frozen shoulder is a disorder of the shoulder joint due to an inflammatory process in the capsular layer of the glenohumeral joint, resulting in stiffness and pain. This condition is relatively common. Diagnosis can be made through history, physical examination, and investigations. Management choices are non-operative and operative methods.
Peran Ultrasonografi pada Tamponade Jantung Akut Akibat Trauma Tumpul Dada
Authors: Tunggal Yahdiel Alexander Nantara , Noor Dharmawan Mursjid , Octavallen Andri 
Published: April 2023

Pendahuluan: Tamponade jantung akut adalah kondisi mengancam nyawa. Point of Care Ultrasound (POCUS) merupakan salah satu modalitas pencitraan yang dinilai sensitif dan spesifik untuk membantu diagnosis. Kasus: Laki–laki, usia 29 tahun, pasca-trauma tumpul dada disertai peningkatan tekanan vena jugular, suara jantung menjauh tanpa hipotensi. Pada pemeriksaan POCUS didapatkan tanda sonografi tamponade. Pasien didiagnosis tamponade jantung akut. Hemodinamik membaik pasca-percutaneous pericardiocentesis ultrasound guiding di trauma bay. Diskusi: Modalitas bedside, seperti ultrasonografi diperlukan untuk menunjang diagnosis dan tata laksana tamponade jantung akut.

Introduction: Acute cardiac tamponade is a life-threatening condition. Point of Care Ultrasound (POCUS) is one of the imaging modalities considered sensitive and specific for diagnosis. Case: Male, 29 years old, post blunt chest trauma with increased jugular vein pressure, distant heart sounds without hypotension. On POCUS examination, sonographic tamponade was found. The patient was diagnosed with acute cardiac tamponade. Hemodynamics improved after percutaneous ultrasound guiding pericardiocentesis in the trauma bay. Discussion: Bedside modalities, such as ultrasonography are needed to support the diagnosis and management of acute cardiac tamponade.
Pengembangan Vaksin Malaria RTS,S/AS01
Authors: Khosasih Andrea Evans 
Published: April 2023

Malaria masih endemik di dunia. Data WHO tahun 2020 mencatat 241 juta kasus malaria di dunia. Rekomendasi vaksin malaria oleh WHO diharapkan dapat membantu menurunkan angka kasus penderita malaria hingga 90% pada tahun 2030 dari baseline tahun 2015.

Malaria is still a world endemic. According to 2020 WHO data, there are 241 million cases of malaria in the world. The WHO malaria vaccine recommendation is expected to help reduce malaria cases by 90% by 2030 from the 2015 baseline.
Teknik Histerosalpingografi
Authors: Anjasmara I Kadek Dwiki , Hendrawardani Dewa Ayu Citra , Wijaya Andre Tjie , Darmiastini Ni Komang 
Published: April 2023

Kelainan uterus dan tuba Falopi merupakan penyebab utama infertilitas. Patologi uterus dan tuba dapat berupa malformasi kongenital atau yang didapat. Beberapa metode pencitraan seperti laparoskopi, fluoroskopi, sonografi infus salin, dan histerosalpingografi (HSG) telah digunakan untuk menilai patologi uterus dan tuba. Meskipun laparoskopi adalah modalitas pilihan untuk menyelidiki patensi tuba dan struktur panggul, HSG merupakan metode diagnostik awal infertilitas karena kemudahan, akurasi, dan risiko komplikasi. Tinjauan ini mengilustrasikan beberapa fitur radiografi kelainan struktur pada uterus dan tuba Falopi.

Abnormalities of the uterus and fallopian tubes are major causes of infertility. Uterine and tubal pathology may be congenital or acquired malformations. Several imaging methods such as laparoscopy, fluoroscopy, infusion saline sonography, and hysterosalpingography (HSG) have been used in the assessment of uterine and tubal pathology. Although laparoscopy is the modality of choice for investigating tubal patency and pelvic structures, HSG is the initial diagnostic method for infertility screening because of its ease of performance, accuracy, and risk of complications that benefit from the size, contour, and surface anatomy of the uterus and fallopian tubes. This review illustrates some of the radiographic features of abnormalities of the uterus and fallopian tubes
Central sensitization in osteoarthritic knee pain: A cross-sectional study
Authors: Özge Kılıçaslan Hamide , Genç Aysun , Tuncer Safiye 
Published: April 2023

Objectives: The aim of this study was to investigate central sensitization and associated factors in knee osteoarthritis (OA) patients and compare them with rheumatoid arthritis (RA) patients and healthy controls.
Patients and methods: This cross-sectional study was conducted with 125 participants (7 males, 118 females; mean age: 57.2±8.2 years; range, 45 to 75 years) between January 2017 and December 2018. Sixty-two patients with symptomatic knee OA, 32 RA patients with knee pain, and 31 healthy controls constituted the participants. Central sensitization was investigated with the Central Sensitization Inventory (CSI) and pressure pain threshold (PPT) measurements. Pain, functional status, and psychosocial features were assessed with self-reported questionnaires.
Results: The OA and RA groups had significantly lower PPT values at local, peripheral, and remote regions compared to the healthy controls. Pressure hyperalgesia was shown at the knee with a 43.5% prevalence, 27.4% at the leg, and 8.1% at the forearm of OA patients. Pressure hyperalgesia was present at the knee, leg, and forearm in 37.5%, 25%, and 9.4% of RA patients, respectively. Pressure pain threshold values, CSI scores, frequency of pressure hyperalgesia, and frequency of central sensitization according to the CSI were not statistically different between the OA and RA groups. Psychosocial features and structural damage were not correlated with PPT values in the OA group.
Conclusion: The severity of chronic pain and functional status may be the clinical clues to recognizing patients with central sensitization since local joint damage does not play a direct role in the etiopathogenesis of central sensitization in OA patients and severe pain persisting in the chronic process is associated with central sensitization regardless of the pathogenesis.
The correlation between six-minute walking distance and maximum phonation time in healthy adults
Authors: Mulya Santausa Febrian , Nusdwinuringtyas Nury , Fransiska Ulianna Tambunan Tresia , Friska Dewi 
Published: April 2023

Objectives: This study aimed to determine the association between six-minute walking distance (6MWD) and maximum phonation time (MPT) in healthy adults.
Patients and methods: The cross-sectional study was conducted with 50 sedentary nonsingers (32 females, 18 males; mean age: 33.5±8.3 years; range, 18 to 50 years) between February 2021 and April 2021. Subjects with a history of smoking, respiratory symptoms in the last two weeks, and heart, lung, musculoskeletal, and balance problems were excluded. The measurements of MPT and 6MWD were carried out by two different assessors blinded to each other.
Results: The mean MPT was higher in male subjects (27.4±7.4 sec vs. 20.6±5.1 sec, p<0.001). In the bivariate analysis, there was a significant correlation between MPT and 6MWD (r=0.621, p<0.001), as well as body height (r=0.421, p=0.002) and the mean fundamental frequency (r=-0.429, p=0.002); however, no association was found with age, body weight, and the mean sound pressure level. After multiple regression, 6MWD was the only factor associated with MPT (p=0.002).
Conclusion: There is a significant association between 6MWD and MPT in healthy adults, and the results suggest that aerobic capacity might have a role in improving the ability to sustain phonation.
Compromised T-cell immunity in patients with spinal cord injury and its relationship with injury characteristics
Authors: Kartal Ozgur , Yilmaz Bilge , Gülec Mustafa , Guzelkucuk Umüt , Kenan Tan Arif , Sener Osman , Muşabak Uğur 
Published: April 2023

Objectives: The aim of this study was to investigate in vivo and in vitro cellular immune responses in patients with chronic (spinal cord injury; SCI), determine the effects of autonomic dysfunction on cellular immune response, and determine the effect of completeness of the injury at different levels on cellular immune response.
Patients and methods: Forty-nine patients (42 males, 7 females; mean age: 35.5±13.4 years; range, 18 to 68 years) with chronic (time since injury >6 months) traumatic SCI were included in this cross sectional study between March 2013 and December 2013. Patients were allocated into two groups: Group 1, patients with an injury at T7 or below, and Group 2, patients with an injury at T6 or above. All patients in Group 2 had a history of autonomic dysreflexia and orthostatic hypotension. Intradermal skin tests were applied to the participants to reveal delayed T-cell responses. The percentages of cluster of differentiation (CD)3+ T cells and CD3+ T cells expressing CD69 and CD25 were analyzed by flow cytometry for the detection of activated T cells including all T-cell subsets.
Results: When patients with complete injuries were compared, the CD45+ cell percentage was found to be significantly higher in patients in Group 2. Patients with an incomplete SCI had increased skin response to candida antigens compared to complete SCI patients. Incomplete SCI patients also had higher percentages of lymphocytes and CD3+CD25+ and CD3+CD69+ T cells compared to patients with complete SCI.
Conclusion: T-cell activity is impaired in chronic SCI patients with higher levels of injury, and the completeness of injury and autonomic dysfunction gain prominence as compromising factors in T-cell immunity.
Mental health in times of COVID-19 in Brazilian society
Authors: Oliveira Campos Evandro , Leão Campos Paula 
Published: April 2023

The COVID-19 pandemic, caused by the SARS-COV2 virus, is a global phenomenon of unique characteristics, in the sense of its extension, speed of growth, general impact on the population and on health services, and also because it occurs in a context of access to a lot of information in a very short time. Thus, some of its impacts are similar to those of other epidemics, others are only being seen at the present moment, and certainly, in the future, the perception of this pandemic will still be modified.

DOI: 10.56238/isevjhv1n3-001