bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lung endothelial cell senescence impairs barrier function and promotes neutrophil adhesion and migration
Authors: Najari Beidokhti Maliheh , Villalba Nuria , Ma Yonggang , Reynolds Amanda , Villamil Juan Hernandez , Yuan Sarah Y. 
Published: January 2025

Abstract
Cellular senescence contributes to inflammation and organ dysfunction during aging. While this process is generally characterized by irreversible cell cycle arrest, its morphological features and functional impacts vary in different cells from various organs. In this study, we examined the expression of multiple senescent markers in the lungs of young and aged humans and mice, as well as in mouse lung endothelial cells cultured with a senescence inducer, suberoylanilide hydroxamic acid (SAHA), or doxorubicin (DOXO). We detected increased levels of p21, γH2AX, and SA-β-Gal and decreased Ki-67 and Lamin B1 in aged lungs and senescent lung endothelial cells. Importantly, the expression of senescent markers was associated with an inflammatory response in aged mouse lungs characterized by neutrophil infiltration, increased expression of intercellular adhesion molecule 1 (ICAM-1), and decreased protein levels of VE-cadherin and ZO-1. As the latter two are critical constituents of endothelial cell–cell junctions, we hypothesized that their decreased expression could lead to compromised junction barrier integrity. Indeed, senescent endothelial cells (ECs) exhibited impaired barrier properties, as measured by increased permeability to solutes of small size (3-kD) and albumin (70-kD). When co-cultured with neutrophils, senescent ECs and their supernatant promoted neutrophil chemotaxis and trans-endothelial migration. Taken together, our results suggest that lung EC senescence weakens cell–cell junctions, impairs barrier function, and promotes neutrophil adhesion and migration, which may contribute to the development of inflammation and related pathologies in the lungs during aging.
Life cycle assessment research and application in Nigeria
Authors: Isah Mohammed Engha , Wasah Ayedu , Matsubae Kazuyo 
Published: January 2025

Abstract

Purpose
Life cycle assessment (LCA) methodology is becoming increasingly popular in developing countries, however, challenges such as lack of local data, spatial and temporal differentiation of impact categories, and uncertainty in the data and impact assessment methods remain. In this comprehensive review, we systematically conduct a literature review of LCA research in Nigeria, including a thorough assessment of the LCA studies according to ISO 14040 and 14044 standards.

Methods
A total of 30 peered reviewed and conference papers on LCA papers Nigeria as the study area of authors affiliated to institutions in the country were assessed. The assessment focused on functional unit, system boundary, data quality, allocation, impact assessment methods, database and LCA software used and interpretation methods.

Results and discussion
The results of the review showed that LCA is still in its infancy in Nigeria with 30 papers on the subject matter published between 2010–2023. These peer reviewed publications came from universities and research institutions, none from companies or government. In terms of the methodological choices, different functional units, system boundaries, impact assessment methods, allocation, data choices, databases and software were used. The Ecoinvent database is one of the most widely used for background data for potential environmental impacts while SimaPro and GaBi are the softwares of choice for most of the studies. Climate Change was the most assessed impact category at the midpoint level for life cycle impact assessment (LCIA). To ensure that uncertainties in LCA results are reduced, studies should ensure transparency in inventories, consider all the life cycle stages, use primary data and adapt local characterisation factors. Local impacts such as gas flaring, biodiversity, oil spills, soil erosion, and desertification should be the focus of LCA method developers in Nigeria as they are the prevailing environmental challenges affecting different parts of the country.

Conclusions and recommendations
Different methodological choices are used by researchers, they highlight a challenge that was noticeable in all the papers – a general lack of primary data. The studies are not equally distributed amongst the sectors of the economy. Most of them are concentrated in the agriculture, energy and transportation sectors. Based on our findings, the authors recommend the development of an LCI database for Nigeria and Nigeria-specific impact pathways, normalisation and weighting factors to enhance the reproducibility of the results. This study lays the foundation for the development of an integrated master plan for the development of LCA in Nigeria, with the potential to significantly contribute to improving environmental assessment and sustainable development.
Précis of A Philosophy for the Science of Animal Consciousness
Authors: Veit Walter 
Published: January 2025

Abstract

A Philosophy for the Science of Animal Consciousness aims to advance Donald Griffin’s vision of the “final, crowning chapter of the Darwinian revolution” by firmly integrating animals within the science of consciousness. Although this field has largely neglected the questions of when and why consciousness evolved, this book champions a Darwinian philosophy where the experiences of other animals are put centre-stage in investigations of consciousness. This synopsis offers a summary of the book’s core arguments for the advancement of a truly biological science of consciousness. This approach allows for an empirically rigorous investigation into what it is like to be a bat, a crow, a bee, or an octopus.
Video Game Structural Features Are Related to Internet Gaming Disorder and Motivations of Play: Design and Validation of the Video Game Structure Scale (VGSS)
Authors: Carmona Arnau , Carbonell Xavier , Bonilla Iván , Ivern Jan , Chamarro Andrés 
Published: January 2025

Abstract
Structural characteristics of video games influence the development of maladaptive behavioral patterns such as Internet gaming disorder (IGD). The aim of this study was to develop and validate a tool to evaluate users’ perceptions of video game structural features. The sample was composed of 502 gamers with an average age of 23.35 years (SD = 6.89). In total, 67.3% used a personal computer, 20.7% a desktop console, 11.4% a mobile platform, and 0.6% a portable console. Multiple exploratory factor analyses were conducted to identify the optimal model. Initial evidence of reliability, construct, and external validity was found (TLI and CFI > .90, RMSEA < .06, SRMR < .08). Structural features were categorized into three primary factors: social, control, and reward. After a multiple linear regression, structural features and gaming motivations explain 19% of the variance in IGD. In conclusion, the scale demonstrates solid psychometric properties for assessing how Spanish-speaking players perceive the structural characteristics of video games and how these relate to the development of IGD.
Learning to read and interpret tattoos
Authors: Byard Roger W. 
Published: January 2025

Abstract
Tattooing has been a facet of many civilizations and cultures for millennia with a recent resurgence in popularity in many Western countries. The reasons for tattooing are diverse ranging from simple decorative designs to enforced tattooing of concentration camp inmates. In a forensic context tattoos are frequently observed and may play a role in some cases of identification, even after decomposition, incineration or dismemberment. More broadly however, tattoos can provide significant information on a decedent’s name and age, country or region of origin, religion, names of family members and friends, pet ownership, political affiliations, sporting and recreational activities, military service, gang memberships, drug usage and medical data. Thus, careful reading of tattoos at the time of post mortem examination can sometimes be a very productive exercise delivering background material on a decedent that may not have been provided in police reports.
The significance of humorous tattoos
Authors: Byard Roger W. 
Published: January 2025

Abstract
Tattooing refers to the process of creating indelible designs and texts in the human skin by introducing a variety of dyes. It has found for millennia in a range of societies. The purpose of tattooing has ranged from marking individuals of significant social standing such as chieftains in Polynesia, to those who are regarded as outcasts such as prostitutes and criminals in Europe. In recent years tattooing has gained considerable popularity in the West including tattoos that have merely had a humorous content, either as an image or text. These types of tattoos often utilize natural body features such as the umbilicus, natal cleft, genitalia, breasts or scars, and may contain simple but explicit messages or suggest possible underlying mental disturbance. While the significance of these types of tattoos and the profile of individuals who have them is at present unknown further study could identify sociological and forensic features specific to this subgroup.
Dose-Dependent Effect of a New Biotin Compound in Hippocampal Remyelination in Rats
Authors: Yulug Burak , Kilic Ertugrul , Oğuz Tuba , Orhan Cemal , Er Besir , Tuzcu Mehmet , Ozercan Ibrahim Hanifi , Sahin Nurhan , Canpolat Sinan , Komorowski James , Ojalvo Sara Perez , Sylla Sarah , Cankaya Seyda , Sahin Kazim 
Published: January 2025

Abstract
Demyelination is commonly observed in neurodegenerative disorders, including multiple sclerosis (MS). Biotin supplementation is known to stabilize MS progression. To reduce the effective dose of biotin, we synthesized a new and superior form of biotin, a complex of magnesium ionically bound to biotin (MgB) and compared its dose-dependent effect with biotin alone after inducing demyelination using lysolecithin (LPC) in rats. Myelination was assessed using luxol fast blue staining and immunostaining against MBP protein, revealing that the most significant remyelination occurred in the MgB groups. Additionally, both biotin and MgB-treated animals showed dose-dependent improvements in spatial memory. Moreover, we detected a decrease in inflammatory proteins in both treatment groups, which was more prominent in high-dose MgB-treated animals and correlated with decreased expression of NF-κB p65, OP, and MMP-9 proteins. Further analysis of biotin-related proteins demonstrated that both biotin and, notably, MgB reversed the demyelination-dependent reduction of these proteins. Furthermore, biotin, particularly MgB, improved neuronal transmission proteins, Synapsin-1, PSD-93, and PSD-95. Additionally, both treatment groups exhibited increased BDNF, GAP43, and ICAM levels, with significant increments observed in high-dose MgB-treated animals. Increased GFAP, indicative of reactive gliosis, was observed in LPC-treated animals, and this effect was notably reversed by high-dose MgB treatment. The current data emphasize the dose-dependent beneficial effect on the remyelination process. Furthermore, the combination of biotin with Mg resulted in a more potent effect compared to biotin by itself. The strong influence of MgB encourages proof-of-concept studies using MgB in patients with MS.
Delayed Progression of Ataxia with a Static Cerebellar Lesion– Consider SCA27B
Authors: Wong Tsz Hang , Manuputty Jamie , van Seeters Tom , Kamsteeg Erik-Jan , van de Warrenburg Bart 
Published: January 2025

Abstract
Repeat expansions in the fibroblast growth factor 14 gene (FGF14), associated with spinocerebellar ataxia type 27B (SCA27B), have emerged as a prevalent cause of previously unexplained late-onset cerebellar ataxia. Here, we present a patient with residual symptom of gait ataxia after complicated meningioma surgery, who presented with progressive symptoms of oculomotor disturbances, speech difficulties, vertigo and worsening of gait imbalance, twelve years post-resection. Neuroimaging revealed a surgical resection cavity in the dorsolateral side of the left cerebellar hemisphere, accompanied by gliosis in left cerebellar hemisphere extending into the vermis, extensive non-specific supratentorial periventricular white matter abnormalities, and mild atrophy of the cerebellar vermis. Initially, her symptoms were attributed to re-emergence of her cerebellar symptoms related to the static cerebellar lesion, and due to a failure of compensatory mechanisms with aging. However, the progressive nature of her cerebellar symptoms and the emergence of novel downbeat nystagmus prompted genetic testing for FGF14 repeat expansion, confirming SCA27B as a significant contributor to her delayed, progressive cerebellar symptoms. This case highlights the significance of considering SCA27B in the differential diagnosis of delayed progressive cerebellar ataxia with oculomotor abnormalities in the presence of a static cerebellar lesion.
MicroRNA in neuroexosome as a potential biomarker for HIV-associated neurocognitive disorders
Authors: Arizono Kotaro , Sedohara Ayako , Tuvshinjargal Khulan , Tanaka Takahiro , Koga Michiko , Nakahara Fumio , Ootani Amato , Kanno Yoshiaki , Ikeuchi Kazuhiko , Saito Makoto , Adachi Eisuke , Tsutsumi Takeya , Yotsuyanagi Hiroshi 
Published: January 2025

Abstract
HIV-associated neurocognitive disorder (HAND) is a complication of chronic inflammation caused by HIV infection that impairs cognitive and motor functions. HAND can occur at any age, regardless of the duration of infection, even in people living with HIV (PLWH) whose blood viral load is controlled by antiretroviral therapy. The diagnosis of HAND requires a battery of neuropsychological tests, which is time-consuming and burdensome, limiting its effectiveness for screening PLWH. Here, we aimed to identify biomarkers for quantitatively diagnosing and screening for HAND using minimally invasive blood tests. Neuronal-derived exosomes (neuroexosomes) were isolated from the peripheral blood of PLWH, and the transcriptomes of their microRNAs (miRNAs) were analyzed. We identified five upregulated miRNAs (hsa-miR-16-5p, hsa-miR-26a-3p, hsa-92a-3p, hsa-miR-103a-3p, and hsa-miR-185-5p), and two downregulated miRNA (hsa-miR-3613-3p and hsa-miR-4668-5p) in PLWH diagnosed with HAND (HAND PLWH). Functional analysis of five miRNAs whose expression levels increased in HAND PLWH using the database showed that these miRNAs are involved in motor proteins and endocytosis, which are associated with nerve function. The expression levels of hsa-miR-16-5p, hsa-miR-103a-3p, and hsa-miR-185-5p were significantly higher than those in the non-HIV controls and non-HAND PLWH, suggesting that these miRNAs are potential biomarkers for HAND. Since there were no changes in known dementia miRNA biomarkers in HAND PLWH, the miRNAs identified in this study will allow for early differentiation of HAND.
Perfectionism and compulsive exercise: a systematic review and preliminary meta-analysis
Authors: Bills Elizabeth , Muir Shannon R. , Stackpole Rose , Egan Sarah J. 
Published: January 2025

Abstract

Purpose
There is a consistent link between perfectionism and compulsive exercise, and both are implicated in the maintenance of eating disorders, however no meta-analysis to date has quantified this relationship. We hypothesised that there would be significant, small-moderate pooled correlations between perfectionism dimensions and compulsive exercise.

Methods
Published, peer-reviewed articles with standardised measures of perfectionism and the Compulsive Exercise Test were included. There were 7 studies included (N = 3117 participants, M age = 21.78 years, 49% female).

Results
Total perfectionism (r = 0.37), perfectionistic strivings (r = 0.33), and perfectionistic concerns (r = 0.32) had significant pooled positive associations with compulsive exercise. Most studies (67%) were rated as fair or good quality as an indication of risk of bias. Limitations included the low number of available studies, the inclusion of only one clinical sample, and predominately cross-sectional studies which precluded causal inference.

Conclusion
Higher perfectionism was associated with higher compulsive exercise. More research is needed on compulsive exercise to determine the best intervention approach given its relationship to perfectionism and relevance in the context of eating disorders.

Level of evidence
Level I: Evidence obtained from a systematic review and meta-analysis.
Alternative Powertrains and Fuels in Heavy Non-Road Mobile Machinery and Their Future Expectations - A Review
Authors: Pesonen Jarkko , Prinz Robert , Ovaskainen Heikki , Kauranen Pertti , Poikela Asko , Kärhä Kalle 
Published: January 2025

Abstract

Purpose of the Review
This literature review focused on studies on alternative powertrains and fuels of non-road mobile machinery (NRMM) during the last 15 years and investigated their future potential and expectations. The goal was to evaluate different alternative powertrains based on previous research and highlight the possibilities and challenges of each technology. Additionally, the aim was to conduct a comprehensive overview about the technology development phase of alternative powertrains.

Recent Findings
This review covered a total of 115 studies consisting of hybrid, full-electric, biofuels, biogas, and hydrogen solutions. The results highlighted that hybrid and full-electric technologies have the greatest potential to replace conventional diesel engines in the future. The main challenges identified were battery reliability and high technology costs. Regarding biofuel, biogas, and hydrogen, the benefits were mainly lower emissions while the challenges were high costs and low production. Full-electric and hydrogen powertrains were found to reach zero local emissions during operations, while compared to diesel, repair and maintenance caused less emissions of 36–46% during the life cycle with full-electric and hydrogen solutions. With hybrid, biofuels, and biogas powertrains, the emission reduction potential ranged from 37 to 81% during operations and 36–66% during the entire life cycle. The highest Technology Readiness Levels (TRLs) were identified for hybrid and full-electric technologies in industrial machinery (6.9–7.4). The lowest measurable TRL (2.5) was with biogas powered construction machinery. The TRLs of biogas and hydrogen of forest machinery were excluded from this review due to the lack of research.

Summary
Alternative powertrains can eventually replace diesel engines, if the challenges with implementation, production, and reliability are solved. Furthermore, the benefits of electric and renewable technologies/fuels are unambiguous from the emission reduction and energy efficiency perspectives. Consequently, we recommend that future research focus especially on the implementation of alternative technologies as well as the improvement of the manufacturing infrastructure.
Bank Resolution and Judicial Review: Lessons of the Banco Popular Litigation
Authors: Lamandini Marco , Ramos Muñoz David 
Published: January 2025

Abstract
Resolution of a troubled institution and the allocation of losses among creditors can be an efficient way to avoid contagion and minimize taxpayer support, but raises major issues of fairness and equity towards shareholders and creditors, which are a source of tensions. The Banco Popular litigation saga offers clear empirical evidence of these tensions. This essay discusses the main lessons that can be drawn from that litigation.
The Flourishing Child: Understanding how Adults and Children Perceive Flourishing from the Start of Life
Authors: Davis Jacqueline A , Davey Belinda , Segers Emily , Talati Zenobia , Silva Desiree , Prescott Susan L , Gibson Lisa Y 
Published: January 2025

Abstract
The current narrative surrounding children’s health and wellbeing often focuses on adversity and dysregulation with a lack of positive messaging. However, promoting protective and buffering factors may be as important as reducing adverse exposures. While the concept of flourishing is commonly applied in the context of adults, defining what flourishing means for children in current academic literature remains unclear. Our study addressed this gap by undertaking a grounded theory approach and consulting extensively with consumers and key stakeholders, both adults and children. This enabled us to elucidate a conceptual framework and identify determinants, as well as to examine perceived barriers and enablers to early childhood flourishing. Triangulating our data revealed that key domains related to childhood flourishing were physical safety, love and family, positive lifestyle, physical and mental health, and fun and happiness. Parents with limited time was a key barrier, while ready access to supports was identified as a key enabler. This conceptualisation of flourishing within the early years lays a theoretical and community informed framework necessary for developing practical tools that will enable parents and carers to assess a child’s capacity to flourish into adolescence and adulthood, thus reinforcing the importance of a healthy start to life.
Non-accountability as post-colonial harm: rethinking the responsibilities of arms producers
Authors: McEvoy Bretton J. , Hönke Jana 
Published: January 2025

Abstract
Despite the inherent dangers of arms production, the responsibility of arms companies to prevent adverse human rights impacts in their business is too often surrounded by silence. What is more, the responsibilities of arms companies are rarely subject to critical historical interrogation, with contemporary arms trade literature paying primary attention to singular export control decisions from a lens of methodological nationalism. This forum contribution brings a post-colonial analysis to the (lack of) political and legal responsibilities demanded of arms companies over time by zooming in on apartheid and post-apartheid South Africa. Grounding in the discursive and material struggles between South African civil society actors and European arms manufacturers/states over the terms of responsibility, we suggest that limited notions of historical responsibility are themselves productive of non-accountability and contemporary harms. The article advocates for a broader understanding of responsibility in the arms sector, and calls for more critical attention and research to be directed towards the historical and transnational situatedness of arms companies and their home states. Such a focus must include recognition of the ways that the denial of reparations serves to (re)produce harm.
Three-dimensional boundary element sensitivity analysis of anisotropic thermoelastic materials
Authors: Fahmy Mohamed Abdelsabour 
Published: January 2025

Abstract
The fundamental goal of this research is to develop a new three-dimensional boundary element method (BEM) for solving thermal stress sensitivity problems in anisotropic materials with a heat source. The problem at hand is incredibly tough to address analytically. As a result, we devised a novel boundary element technique to address this problem. The use of quadratic isoparametric elements and constant volume heat source to depict displacement and temperature fields is one of the driving forces behind the requirement to quantify thermal stresses in engineering structures. In three-dimensional scenarios, the impacts of isotropic, orthotropic, and anisotropic due to the presence or absence of a heat source on thermal stress sensitivity are investigated. The resulting linear systems were solved using the three-block splitting (TBS) iteration strategy, which reduced both the number of iterations and CPU time. The new TBS iteration method converges quickly and does not require complex calculations. It exceeds the other iterative methods for solving the resulting BEM linear system. To compare with other articles in the literature, we only considered the two-dimensional model as a subset of our three-dimensional model. The numerical data illustrate the accuracy, precision, and effectiveness of our proposed BEM methodology, as the BEM results are highly consistent with the finite difference method (FDM) and finite element method (FEM) results.