bluuebunny/crossref_metadata_2025_split huggingface dataset:
A new validated facile HPLC analysis method to determine methylprednisolone including its derivatives and practical application
Authors: Al-Hakkani Mostafa F. 
Published: July 2023

AbstractMethylprednisolone sodium succinate (MPSS) is a parenteral water-soluble corticosteroid ester. It gives three peaks methylprednisolone (MP), 17-methylprednisolone hemisuccinate (17-MPHS), and methylprednisolone hemisuccinate (MPHS) that share in the assay determination as total MP. It is used on a wide scale in prescribed anti-inflammatory drugs as a common use. The current study aimed to find a rapid RP-HPLC method of MP and its derivatives analysis with high linearity, repeatability, sensitivity, selectivity, and inexpensive to use without the need for any special chemical reagents. The use of the current method achieved a satisfactory result to detect, determine and separate the MP, 17-MPHS, and MPHS in a short time. The chromatographic system consists of RP-HPLC using the BDS column (250 mm × 4.6 mm × 5 μm). The mobile phase was prepared by mixing the WFI: glacial acetic acid: acetonitrile in a volume ratio (63:2:35) at a flow rate of 2.0 mL/min with detection wavelength at 254 nm at room temperature and injection volume 20 μL. The method manifested a satisfied linearity regression R2 (0.9998–0.99999) with LOD 143.97 ng/mL and 4.49 µg/mL; and LOQ 436.27 ng/mL and 13.61 µg/mL for MP and MPHS respectively. The method proved its efficiency via system suitability achievement in the robustness and ruggedness conduction according to the validation guidelines. High sensitivity according to its LOD and LOQ. So, the current method could be considered in the pharmaceutical industry. The suggested method has been successfully implemented in the Egyptian local market for the quantitative assessment of the assay of the finished product.
Enhanced light focusing inside scattering media with shaped ultrasound
Authors: Mestre-Torà Blanca , Duocastella Martí 
Published: July 2023

AbstractLight focusing is the primary enabler of various scientific and industrial processes including laser materials processing and microscopy. However, the scattering of light limits the depth at which current methods can operate inside heterogeneous media such as biological tissue, liquid emulsions, and composite materials. Several approaches have been developed to address this issue, but they typically come at the cost of losing spatial or temporal resolution, or increased invasiveness. Here, we show that ultrasound waves featuring a Bessel-like profile can locally modulate the optical properties of a turbid medium to facilitate light guiding. Supported by wave optics and Monte Carlo simulations, we demonstrate how ultrasound enhances light focusing a factor of 7 compared to conventional methods based on placing optical elements outside the complex medium. Combined with point-by-point scanning, images of samples immersed in turbid media with an optical density up to 15, similar to that of weakly scattering biological tissue, can be reconstructed. The quasi-instantaneous generation of the shaped-ultrasound waves, together with the possibility to use transmission and reflection architectures, can pave the way for the real-time control of light inside living tissue.
Relationships of rapid eating with visceral and subcutaneous fat mass and plasma adiponectin concentration
Authors: Tsumura Hideki , Fukuda Mari , Hisamatsu Takashi , Sato Rie , Tsuchie Rina , Kanda Hideyuki 
Published: July 2023

AbstractRapid eating has been demonstrated to be associated with obesity and overweight. However, few studies have characterized the separate relationships of eating speed with visceral and subcutaneous fat mass or circulating adiponectin concentration. We hypothesized that rapid eating is associated with the larger visceral fat tissue (VFT) area and lower adiponectin concentration, but not with the subcutaneous fat tissue (SFT) area in men and women. We performed a cross-sectional study of 712 adults aged 20–86 years (528 men and 184 women; mean ± SD age 59.36 ± 13.61 years). The participants completed a self-reported questionnaire, and underwent anthropometric and laboratory measurements and computed tomographic imaging of the abdomen as a part of annual medical check-ups. Multivariate linear regression analyses revealed that rapid eating was associated with larger visceral (B = 24.74; 95% CI 8.87–40.61, p = 0.002) and subcutaneous fat areas (B = 31.31; 95% CI 12.23–50.38, p = 0.001), lower adiponectin concentration (B =  − 2.92; 95% CI − 4.39– − 1.46, p < 0.001), higher body mass index (BMI) (B = 2.13; 95% CI 1.02–3.25, p < 0.001), and larger waist circumference (B = 5.23; 95% CI 2.16–8.30, p < 0.001) in men, which is partially consistent with the hypothesis. In contrast, rapid eating was found to be associated only with BMI, and not with abdominal adipose area or adiponectin concentration in women, which is a result that is not consistent with the hypothesis. These results suggest that there is no difference in the association of rapid eating with VFT and SFT areas.
Cross-mating between the alien bumblebee Bombus terrestris and two native Japanese bumblebees, B. hypocrita sapporensis and B. cryptarum florilegus, in the Nemuro Peninsula, Japan
Authors: Kubo Ryohei , Asanuma Yuine , Fujimoto Erina , Okuyama Hisashi , Ono Masato , Takahashi Jun-ichi 
Published: July 2023

AbstractThe rapid naturalization of Bombus terrestris across the Nemuro Peninsula has led to a decline in two closely related native Japanese species, namely Bombus hypocrita sapporensis and Bombus cryptarum florilegus, both belonging to the common subgenus Bombus. Although it is widely believed that cross-mating of native and non-native species is influenced by the common male sex pheromone in this region, no study has been conducted to substantiate this claim. Thus, we investigated the cross-activities of male sex pheromones between native and non-native bumblebees, as well as the frequencies of cross-mating, using chemical and DNA assays. Our gas chromatography–electroantennographic detector analyses and behavioral tests revealed the presence of sex pheromonal cross-activities between B. terrestris and the two Japanese bumblebees species. Furthermore, DNA analyses revealed the occurrence of cross-mating between native and non-native species in the Nemuro Peninsula. Overall, these results indicate the immediate need for conservation measures to safeguard Japanese bumblebee populations in the Nemuro Peninsula.
Open quantum system violates generalized Pauli constraints on quantum device
Authors: Avdic Irma , Sager-Smith LeeAnn M. , Mazziotti David A. 
Published: July 2023

AbstractThe Pauli exclusion principle governs the fundamental structure and function of fermionic systems from molecules to materials. Nonetheless, when such a fermionic system is in a pure state, it is subject to additional restrictions known as the generalized Pauli constraints (GPCs). Here we verify experimentally the violation of the GPCs for an open quantum system using data from a superconducting-qubit quantum computer. We prepare states of systems with three-to-seven qubits directly on the quantum device and measure the one-fermion reduced density matrix (1-RDM) from which we can test the GPCs. We find that the GPCs of the 1-RDM are sufficiently sensitive to detect the openness of the 3-to-7 qubit systems in the presence of a single-qubit environment. Results confirm experimentally that the openness of a many-fermion quantum system can be decoded from only a knowledge of the 1-RDM with potential applications from quantum computing and sensing to noise-assisted energy transfer.
Symmetry-protected Bose-Einstein condensation of interacting hardcore bosons
Authors: Wilke Reja H. , Köhler Thomas , Palm Felix A. , Paeckel Sebastian 
Published: July 2023

AbstractThe large practical potential of exotic quantum states is often precluded by their notorious fragility against external perturbations or temperature. Here, we introduce a mechanism stabilizing a one-dimensional quantum many-body phase exploiting an emergent $${{\mathbb{Z}}}_{2}$$

Z

2

-symmetry based on a simple geometrical modification, i.e. a site that couples to all lattice sites. We illustrate this mechanism by constructing the solution of the full quantum many-body problem of hardcore bosons on a wheel geometry, which are known to form Bose-Einstein condensates. The robustness of the condensate against interactions is shown numerically by adding nearest-neighbor interactions, which typically destroy Bose-Einstein condensates. We discuss further applications such as geometrically inducing finite-momentum condensates. Since our solution strategy is based on a generic mapping, our findings are applicable in a broader context, in which a particular state should be protected, by introducing an additional center site.
Analytical models of the crosstalk voltage in SiC MOSFETs under different loads
Authors: Xu Hao , Cai Yumeng , Sun Peng , Zhao Zhibin , Cao Boyuan 
Published: July 2023

AbstractDue to the higher switching speed and lower threshold voltage of SiC MOSFET, its crosstalk issue is more serious than that of Si devices. Firstly, the mechanism and process of crosstalk under resistive load and inductive load are compared and analyzed. Then, a parameter decoupling method based on energy conservation is proposed, and an analytical model of the crosstalk voltage under resistive load is established. Moreover, an analytical model of the crosstalk voltage under inductive load with only device and circuit parameters is introduced. Furthermore, the influence of the drive resistance and the common source inductance on the crosstalk voltage under different loads is evaluated through the analytical model. Finally, a double pulse test is carried out to verify the validity of the analysis. The results presented here can provide guidance for the design of gate circuit parameters to regulate the crosstalk issue of SiC MOSFETs under different loads.
The ultra-long GRB 220627A at z = 3.08
Authors: de Wet S. , Izzo L. , Groot P. J. , Bisero S. , D’Elia V. , De Pasquale M. , Hartmann D. H. , Heintz K. E. , Jakobsson P. , Laskar T. , Levan A. , Martin-Carrillo A. , Melandri A. , Nicuesa Guelbenzu A. , Pugliese G. , Rossi A. , Saccardi A. , Savaglio S. , Schady P. , Tanvir N. R. , van Eerten H. , Vergani S. D. 
Published: July 2023

Context. GRB 220627A is a rare burst with two distinct γ-ray emission episodes separated by almost 1000 s that triggered the Fermi Gamma-ray Burst Monitor twice. High-energy GeV emission was detected by the Fermi Large Area Telescope coincident with the first emission episode but not the second. The discovery of the optical afterglow with MeerLICHT led to MUSE observations which secured the burst redshift to z = 3.08, making this the most distant ultra-long gamma-ray burst (GRB) detected to date.
Aims. The progenitors of some ultra-long GRBs have been suggested in the literature to be different to those of normal long GRBs. Our aim is to determine whether the afterglow and host properties of GRB 220627A agree with this interpretation.
Methods. We performed empirical and theoretical modelling of the afterglow data within the external forward shock framework, and determined the metallicity of the GRB environment through modelling the absorption lines in the MUSE spectrum.
Results. Our optical data show evidence for a jet break in the light curve at ∼1.2 days, while our theoretical modelling shows a preference for a homogeneous circumburst medium. Our forward shock parameters are typical for the wider GRB population, and we find that the environment of the burst is characterised by a sub-solar metallicity.
Conclusions. Our observations and modelling of GRB 220627A do not suggest that a different progenitor compared to the progenitor of normal long GRBs is required. We find that more observations of ultra-long GRBs are needed to determine if they form a separate population with distinct prompt and afterglow features, and possibly distinct progenitors.
Nachhaltiger Umgang mit Abfällen im OP – ein schwieriges Thema mit großem Potential
Authors: Welter Stefan , Schmalbach Ingo Lukas , Meierling Stefan , Blaumann Laura , Klotz Laura 
Published: July 2023

ZusammenfassungBei einem operativen Eingriff fallen große Mengen Müll an. Kontaminierter Müll muss direkt thermisch verwertet werden und darf nicht nach Wertstoffen sortiert werden. Die Klassifizierung
des Krankenhausmülls erfolgt nach Gefahrenpotenzial nach europäischer Abfallschlüsselnummer (AS), anhand derer leider nicht erkennbar ist, welcher Wertstoff darin enthalten ist. Nur ca. 5%
des Krankenhausmülls sind durch Kontakt mit meldepflichtigen Krankheitserregern nach § 6 Infektionsschutzgesetz (IfSG) als infektiös zu werten und müssen als „gefährliche Abfälle“ verbrannt
oder anderweitig sterilisiert werden. Durch getrennte Sammlung von Verpackungsmaterial, ohne Kontamination mit Körpersekreten, können im OP bis zu 50% Müll kostenlos über das Duale System
entsorgt werden. Hierüber gelangen immerhin bis zu 30% der Verpackungen in eine wertstoffliche Wiederverwertung. Das Recycling kontaminierter hochwertiger metallischer Einmalinstrumente ist
nur möglich, wenn ein behördlich genehmigter Desinfektionsprozess durchlaufen wird. Hierfür werden 2 Beispiele dargestellt. Einzelne Abfallfraktionen (z. B. Papier, Pappe, Kartonagen oder
Leichtverpackungen aus PET) können aber auch direkt an Recyclingunternehmen verkauft werden. Fazit: Ein nachhaltiger Umgang mit Müll aus dem OP schont Ressourcen, schont die Umwelt, spart
Geld und spricht viele Mitarbeiter an, denen die Zukunft unseres Planeten eine Herzensangelegenheit ist. Für die Etablierung eines nachhaltigen Abfallwirtschaftskonzeptes ist die Einbindung
aller Mitarbeiter von Beginn an wichtig. Ärzte können hier eine Vorbildfunktion übernehmen.
Colonoscopy-assisted percutaneous sigmoidopexy (CAPS) for complete rectal prolapse treatment: Case series
Authors: Takahashi Junji , Yoshida Masashi , Kamada Teppei , Nakashima Keigo , Nakaseko Yuichi , Suzuki Norihiko , Ohdaira Hironori , Suzuki Yutaka 
Published: July 2023

Abstract
Background and study aims We have previously reported on the effectiveness of colonoscopy-assisted percutaneous sigmoidopexy (CAPS) for sigmoid volvulus treatment. This study describes the CAPS application to treat complete rectal prolapse by straightening and fixing the rectum. Complete rectal prolapse is common in older women. Due to their comorbidities, management must comprise a simple, safe, and reliable surgical method not involving general anesthesia or colon resection.
Patients and methods We enrolled 13 patients in our outpatient department diagnosed with complete rectal prolapse between June 2016 and 2021. The endoscope was advanced into the anterior proximal rectal wall, straightening the intussuscepted sigmoid colon and rectum to approximate the puncture site. The fixation sites were anesthetized with 1% xylocaine, and a 2-mm skin incision was made using a scalpel. A two-shot anchor was used to fix the sigmoid colon to the abdominal wall (Olympus, Tokyo, Japan).
Results The median patient age was 88 years (range: 50–94). The median CAPS procedure time was 30 minutes (range: 20–60). In one patient, the transverse colon was accidentally punctured and interposed between the abdominal wall and sigmoid colon, requiring a laparotomy to remove the causative fixation thread and provide re-fixation. Fecal incontinence was resolved in 10 of 13 cases.
Conclusions CAPS is a quick and simple procedure. In addition, it is a treatment option for complete rectal prolapse that can be performed under local anesthesia.
Robust spin torque switching of noncollinear antiferromagnet Mn3Sn
Authors: Xu Teng , Bai Hao , Dong Yiqing , Zhao Le , Zhou Heng-An , Zhang Junwei , Zhang Xi-Xiang , Jiang Wanjun 
Published: July 2023

Electrical switching of topological antiferromagnetic states in Mn3Sn thin films has been a subject of active investigation. However, dependences of switching behaviors on the film thickness, external field, and crystal orientation remain to be fully explored, which motivate the present study. In this work, (112̄0)-orientated Mn3Sn thin films are fabricated on sapphire substrates, in which a large anomalous Hall effect over a wide temperature range (270–400 K) can be identified. The current-induced spin–orbit torques (SOTs) are utilized to electrically manipulate the topological antiferromagnetic states in Mn3Sn/Pt bilayers. The robust SOT switching can be realized in Mn3Sn films with thicknesses up to 100 nm and with in-plane fields up to 1200 mT. Furthermore, SOT switching behaviors that are independent of the choice of crystal orientations are clearly revealed. Our results could be useful for implementing Mn3Sn films for efficient and stable antiferromagnetic spintronics.
Exploring interdisciplinary communication pathways for escalating pre-medical emergency team deterioration: a mixed-methods study
Authors: Sprogis Stephanie K. , Currey Judy , Jones Daryl , Considine Julie 
Published: July 2023

Objective To explore clinicians’ use and perceptions of interdisciplinary communication pathways for escalating care within the pre-medical emergency team (pre-MET) tier of rapid response systems. Method A sequential mixed-methods study was conducted using observations and interviews. Participants were clinicians (nurses, allied health, doctors) caring for orthopaedic and general medicine patients at one hospital. Descriptive and thematic analyses were conducted. Results Escalation practices were observed for 13 of 27 pre-MET events. Leading communication methods for escalating pre-MET events were alphanumeric pagers (61.5%) and in-person discussions (30.8%). Seven escalated pre-MET events led to bedside pre-MET reviews by doctors. Clinician interviews (n = 29) culminated in two themes: challenges in escalation of care, and navigating information gaps. Clinicians reported deficiencies in communication methods for escalating care that hindered interdisciplinary communication and clinical decision-making pertaining to pre-MET deterioration. Conclusion Policy-defined escalation pathways were inconsistently utilised for pre-MET deterioration. Available communication methods for escalating pre-MET events inadequately fulfilled clinicians’ needs. Variable perceptions of escalation pathways illuminated a lack of of a shared mental model about clinicians’ roles and responsibilities. To optimise timely and appropriate management of patient deterioration, communication infrastructure and interdisciplinary collaboration must be enhanced.
Food shortage and the effect on growth, condition factor and fitness of Trevally (Caranx ignobilis) under rearing condition
Authors: Mosse J W , Hutubessy B G , Zaini M 
Published: July 2023

Abstract

Caranx ignobilis, is one of the iconic culture species in Ambon inner bay recently, unfortunately feeding remains problematic, yet is of profound importance. This study is aimed to examine the effect of feeding and unfed period cycles on growth trajectories and the well being during treatment. In totall, 259 fish ranging in size of 17.05cm-20.47cm SL and weight between 142.00 gr - 221.25 gr were subjected to receive three different feeding regimes. All fish were kept in 3x3x3m pollyethylene net cages receiving 1 day unfed and 1 day re-feeding (1F1RF), 2 days unfed and 2 days re-feeding (2F2RF), 3 days unfed and 3 days re-feeding (3F3RF) were compared to the fish feed daily as control group. Low value fish of shortfin scad, Decapterus macrosoma, were given twice per day at 0900hrs-1000hrs am and 1600hrs-1700hrs pm as much as 15% of total biomass. Standard length and weigth were recorded once per two weeks for 5 months. Analysis of mean length at harvest time showed no significant differences (Fα 0.05 : 1.6297 <Fcritical
, 0,05 (1), 3,36 = 2,866. Weight gain however, exhibited significant differences (F, α 0.05 = 3,239 >Fcritical
= 2,866). Tukey test among treatments and control revealed significant differences, q value range from 8,23-14,29>qcritical0,05, 36, 4 = 3,845. No significant difference, however among treatments; q = 3,2<q 0,05,36,4 = 3,845. The value of CC > 1 indicating growth compensation, while the RCF = 1.36 suggesting the same body condition with control group and remain in good fit.
Promoting sustainable fisheries and aquaculture – Enabling policies, innovation and challenges for achieving sustainable blue economies in Ambon, Maluku Province, Indonesia
Authors: Kobayashi M 
Published: July 2023

Abstract
Sustainable blue economies have become a priority policy for coastal and island countries. It is also the case for Indonesia as it is an archipelago country endowed with a wide-spreading ocean. It must be sustained by key guiding policy principles such as environmental conservation, sustainable management of natural resources, and livelihood improvement. These policy objectives must be pursued in an integrated and coherent manner. Yet, Indonesia faces multiple governance challenges to achieve such goals. Multi-stakeholder and cross-sectoral collaborations are indispensable. Innovation is also needed for policy development, technological advancement, and social partnership. Capacity development is a policy imperative at the local, sub-national, and national levels. International partnership is also important to promote transboundary and sub-regional ecosystem-based and collective marine resource management in the context of achieving sustainable blue economies particularly, through sustainable fisheries and eliminating illegal, unreported, and unregulated fishing. Multifaceted and interdisciplinary approaches need to be reinforced to overcome composite challenges.
Reproduction pattern on Melanotaenia ajamaruensis (Allen & Cross 1980) the endemic rainbowfish of Lake Ajamaru Papua, Indonesia fed by Spirulina
Authors: Said D S , Mayasari N , Triyanto  , Kadarini T 
Published: July 2023

Abstract

Melanotaenia ajamaruensis with the common name Ajamaru Rainbowfish belongs to Rainbowfish group that endemic of Lake Ajamaru Papua, Indonesia. These fish are very potential as ornamental fish, but the biological information is very rare. The fish has just domesticated, therefore a research to inceased the reproductive factors in captivity is needed. The research of reproduction ability was conducted by using various levels of Spirulina in feed (A=0; B=3, and C=6%) during 40 days (September-October 2020) at the RC for Limnology-Indonesian Institute of Sciences Laboratory. Fish rearing used an aquarium sized. of 45x45x40 cm with two replications and the analysis was carried out descriptively. Treatment C (feed 6% Spirulina) had advantages in total eggs (220 eggs), number of eggs per female (110 eggs/female), total number of larvae (214 larvae), number of larvae per female (107 larvae/female), survival rate 7-day and 15-day of larvae were 96.502±8.414% and 91.829±14.030%, respectively. Treatment B (3% Spirulina) had advantages in spawning frequency (12 times), fertilization rate/FR (100%), hatching rate/HR (100%) and shortest egg incubation time (5,916±1,676 days). Spirulina was able to increase the reproductive ability of the endemic fish M ajamaruensis in a captivity conditions. Further research of this fish is still needed.