bluuebunny/crossref_metadata_2025_split huggingface dataset:
The impact of health capital investments on mortality from cardiovascular disease, cancer and diabetes in Africa: a pooling data analysis
Authors: Njifen Issofou 
Published: January 2023

Abstract

Background
African countries face serious challenges from infectious diseases such as malaria and tuberculosis due to the weak health systems and the poor infrastructure. Over the last decades, they are undergoing a demographic transition leading to increasing prevalence of non-communicable diseases such as cancer, cardiovascular diseases and diabetes which their health systems are ill equipped to handle. The prevalence of these chronic diseases is increasing becoming the main cause of mortality in the Africa region. To inform health system responses to these changing patterns of disease, we aimed to assess the effects of health capital investments on chronic diseases mortality in Africa.
Methods
We use a pooling data covering 40 countries from 2005 to 2021. A system Generalized Method of Moments is adopted as the estimation technique of dynamic panel model.
Results
The results suggest that health capital investment has a positive effect on chronic diseases mortality reduction in pooling data, independently of gender considerations. Furthermore, rising health capital investments is associated with greater chronic disease mortality rates in low-income countries and reduces in middle/high-income countries. In addition, chronic diseases mortality also depend on urbanization, unemployment, and alcohol and tobacco consumption.
Conclusions
Findings from this study suggest several main policy orientations, especially policies that aim to increase spending efficiency. The main challenge here is to reconcile current health needs, human resources planning, and available resources.
The “Operating Room Surgical Activity” (ORSA) study: a snap-shot international survey on the global management of the operating theatres for emergency surgery. When to persist is diabolical…
Authors: De Simone Belinda , Agnoletti Vanni , Rosato Chiara , Kaafarani Haytham , Stahel Philip F , Collaborative ORSA , Catena Rodolfo , Catena Fausto 
Published: January 2023

Abstract
Background
Despite advances and improvements in the management of surgical patients, emergency and trauma surgery is correlated with high morbidity and mortality. This is mostly due to delays in the management of patients from admission to surgical treatment in the operating room.
There is a lack of studies focused on operating room prioritization and resource allocation in emergency surgery.
The Operating Room Surgical Activity (ORSA) study was conceived to assess the management of operating theatres and resources from a global perspective.
Method
The ORSA study was conceived as an international web survey. The questionnaire was composed of 23 multiple-choice and open questions.
Data were collected over 3 months.
Participation in the survey was voluntary and anonymous.
Results
One hundred forty-seven emergency and acute care surgeons answered the questionnaire; the response rate was 7.35%.
Most of the participants come from Europe.
One hundred nineteen surgeons (81%; 119/147) declared to have at least 1 emergency OR in their hospital; for the others 20/147 surgeons (19%), there is not a dedicated emergency operating room.
Forty-six (68/147) % of surgeons use the elective operating room to perform emergency procedures during the day,
The planning of an emergency surgical procedure is made by phone (70%-104/147 of surgeons).
Conclusions
There is no dedicated emergency operating room in the majority of hospitals.
The emergency operating room is not always available.
Elective surgical procedures were postponed or cancelled to perform emergency surgery.
It is a priority to validate an effective universal triaging and scheduling system to allocate emergency surgical procedures.
Logistical issues have to be assessed in a multidisciplinary approach to improving patients' safety, optimal use of resources, and decreasing costs.
A simple method to enhance the interface properties of carbon fibre/polyamide 6 composites: Grafted caprolactam-blocked 3-isocyanatopropyltriethoxysilane on carbon fibre surface
Authors: Sun Na , Zhu Bo , Cai Xun , Yuan Xiaomin , Zhang Ye , Zhou Jiaqi , Yan Shuhan , Li Chengsen , Zhou Mingzhe , Zheng Qi 
Published: January 2023

Abstract
Introducing the isocyanate group on the carbon fibre (CF) to improve surface activity is an effective modification method. Still, its application in the industrial field is restricted because the modification process is harmful to the environment and isocyanate is easy to fail. In this paper, 3-isocyanopropyltriethoxysilane (IPTS) has been blocked with caprolactam (CPL) have been prepared. By adjusting the hydrolysis conditions and concentration of the modified coupling agent solution, the CPL-blocked IPTS was grafted to the surface oxidized CF, and the CF-reinforced polyamide 6 (PA6) composites were prepared. After treating CF with 1.0wt% coupling agent solution, the composites’ interlaminar shear strength (ILSS) reached 52.53 MPa, which was 23.83% greater than that of the desized CF/PA6 composites. High-temperature composite molding caused CPL-blocked IPTS to unblock, and the isocyanate that was released thermally intereacted with the terminal amino group of PA6 to establish a high strength interface through covalent grafting, which was the main reason for improving ILSS. This study indicates that this method is safe and simple and can effectively improve the interface properties of CF/PA6 composites.
Bifurcation results for quasi-linear operators from the Fučik spectrum of the Laplacian
Authors: Zongo Wend-Benedo Emmanuel 
Published: January 2023

Abstract

In this paper, we analyze an eigenvalue problem for a quasi-linear elliptic operators involving Dirichlet boundary condition in an open smooth bounded set of RN. We investigate a bifurcation results (from trivial solution and from infinity) of an eigenvalue problem involving the (p,2)-Laplace operator, from the Fučik spectrum of the Laplacian.
2010 Mathematics Subject Classification: 35J20, 35J92, 35J25.
Salinity fluctuations in a brackish-water lake influence the dissolved organic matter characteristics of pore water
Authors: Xie Lei , Zuo Dezhi , Ma Yushen , Zhu Xiang , Xu Bin , He Fei , Pang Qingqing , Wang Longmian , Peng Fuquan , Ni Lixiao , Jiang Wenjuan , Dong Haibo 
Published: January 2023

Abstract
The dissolved organic matter (DOM) compositions in lake water have been widely studied; however, it is not clear how salinity fluctuations in brackish lakes with reeds affect DOM transformation in pore water. This experiment included three salinity groups (1,200 mg/L, 3,600 mg/L, and 6,000 mg/L) to research the interactions between bacteria and DOM in sediments under a salinity gradient. The results showed that higher salinity reduced the Fmax of protein-like substances and resulted in DOM becoming more aromatic and endogenous. Salinity affected DOM compositions due to the responses of functional bacterial communities. Thiobacillus was salt-tolerant and dominated in the sediments, the relative abundances of which were negatively correlated with the Fmax of the protein-like components. The relative abundance of Flavobacterium showed a positive correlation with salinity and a negative correlation with the Fmax of fulvic acid-like and tryptophan-like components. Pseudomonas showed negative correlations with salinity and the Fmax of fulvic acid-like substances and a positive correlation with the Fmax of protein-like substances. Higher salinity inhibited the tryptophan degradation metabolic pathway and enhanced tryptophan biosynthesis. In addition, higher salinity simultaneously inhibited tyrosine biosynthesis and metabolism pathways. The results of this study may provide a new idea for understanding DOM cycling in brackish lake and organic pollution management.
Reducing of the System Load Using Asynchronous and Synchronous Service Methods
Authors: Zakirov Vakhid , Abdullaev Eldor , Shukurov Farrukh 
Published: January 2023

Abstract
In this article, the method of providing services to users through synchronous and asynchronous service methods and its mathematical models are presented. Also, the amount of load falling on systems organized in a synchronous and asynchronous form and its probabilities of losses during the service provided by transparent loss, waiting and conditional loss methods are mentioned. And with the help of these methods, the effectiveness of the distance education system was considered. In this case, the system quality efficiency is calculated separately for the principles of expectation, conditional and transparent loss. In the calculations, the change in the load entering the system was made depending on the number of waiting places and the change in the waiting time. Also, the graphs of the calculation results are presented and the differences in their efficiency indicators are determined. At the same time, the purpose of using synchronous and asynchronous service methods is to reduce the load on the system and increase the number of users of the system, and it has been determined that the load in asynchronous systems is 2–3 times less than in synchronous systems.
CPSF3 modulates the balance of circular and linear transcripts in hepatocellular carcinoma
Authors: Huang Ying , Dong Jiani , Wang Xueying , Ji Haofei , He Zhilin , Cheng Zeneng , Zhu Qubo 
Published: January 2023

Abstract
Background: CircRNAs play an important role in tumorigenesis and metastasis, and their expression is comprehensively downregulated in hepatocellular carcinoma (HCC). Previous studies have shown that the polyadenylation signal1 is critical for circRNA expression, while the 3’-end processing complex participates in circRNA cyclization. As a core executor of 3’-end cleavage, we hypothesized that CPSF3 modulates the circularization of circRNA.
Methods: The clinical prognostic correlation was analyzed by TCGA database and tissue microarrays. Cytological experiments were performed to determine the role of CPSF3 in the proliferation and migration of HCC cells. The Red/GFP dual fluorescent reporter system was employed to explore the mechanism of RNA back-splicing regulated by CPSF3 protein and PAS sequences. The circRNAs regulated by CPSF3 were screened by RNA-seq and further validated by real-time PCR and dot blotting. Changes in the activity of downstream pathways were explored by various molecular experiments. Finally, the safety and efficacy of the CPSF3 inhibitor JTE-607 were verified by in vitro cytology experiments and in vivo xenograft nude mouse models.
Results: CPSF3 was highly expressed in HCC cells and promoted the proliferation and migration of HCC cells. Its high level of expression predicted poor prognosis in HCC patients. Mechanistic study revealed that CPSF3 enhanced RNA cleavage, thereby reducing circRNA levels, increasing linear mRNA levels, and ultimately inhibiting miRNA-mediated gene silencing. Furthermore, the chemical inhibition of CPSF3 by JET-607 suppressed the proliferation of HCC cells both in vitro and in vivo.
Conclusions: Our findings indicate that the increased expression of CPSF3 in HCC promotes the shift of pre-mRNA from circRNA to linear mRNA, thereby disrupting miRNA-mediated gene silencing and ultimately leading to uncontrolled cell proliferation. JTE-607, a CPSF3 inhibitor, exerted a therapeutic effect on HCC by blocking CPSF3 activity.
Host-response Transcriptional Biomarkers Accurately Discriminate Bacterial and Viral Infections of Global Relevance
Authors: Ko Emily R. , Reller Megan E. , Tillekeratne L. Gayani , Bodinayake Champica K. , Miller Cameron , Burke Thomas W. , Henao Ricardo , McClain Micah T. , Suchindran Sunil , Nicholson Bradly , Blatt Adam , Petzold Elizabeth , Tsalik Ephraim L. , Nagahawatte Ajith , Devasiri Vasantha , Rubach Matthew P. , Maro Venance P. , Lwezuala Bingileki F. , Kodikara-Arachichi Wasantha , Kurukulasooriya Ruvini , Silva Aruna D. , Clark Danielle V. , Schully Kevin L. , Madut Deng , Dumler J. Stephen , Kato Cecilia , Galloway Renee , Crump John A. , Ginsburg Geoffrey S. , Minogue Timothy D. , Woods Christopher W. 
Published: January 2023

Abstract
Limited diagnostics challenge management of acute febrile illness and sepsis (AFI/sepsis) globally. We generated transcriptomes for a 294-participant (USA, Sri Lanka) discovery cohort with AFI/sepsis. We used lasso to derive gene expression classifiers followed by cross-validation and generated: 1) a single model to distinguish bacterial vs. viral (Global Fever-Bacterial/Viral [GF-B/V]) and 2) a two-model system to discriminate bacterial and viral in the context of noninfection (Global Fever-Bacterial/Viral/Non-infectious [GF-B/V/N]). We then translated to a multiplex RT-PCR assay and independent validation involved 101 participants (USA, Sri Lanka, Australia, Cambodia, Tanzania). The sensitivity of the GF-B/V model in the discovery cohort was 84.2% and specificity 94.7%. Validation in an independent cohort showed the GF-B/V model had sensitivity of 78.8% and specificity of 84.3%. Similarly, the discovery cohort performance characteristics for bacterial infection for the GF-B/V/N model were was 87.7% sensitivity and 84.2% specificity, respectively. For viral infection, the sensitivity was 83.7% and specificity 81.5%. In independent validation, the sensitivity and specificity were 82.7% and 80.4%, respectively, for bacterial infection and 76.5% and 80.8%, respectively, for viral infection. Performance did not vary with age, demographics, or site. Host transcriptional response diagnostics distinguish bacterial and viral illness across global sites with different endemic pathogens.
Features of the Сrystal Structure of Benzyl Derivatives of Triacanthine. Effect of Weak Interactions on the Formation of Stable Channel Type Solvates
Authors: Turgunov Kambarali K. , Izotova Lidiya Yu. , Tashkhodzhaev Bakhodir , Rakhimov Shukhrat. B. , Vinogradova Valentina I. 
Published: January 2023

Abstract

The alkaloid triacanthine was isolated from Gleditschia triacanthos and its di- and tribenzyl derivatives were synthesized. Both compounds are crystallized in the R-3 space group with same unit cell parameters. A channel is formed in the crystals, in which water molecules with large thermal parameters located on the c axis on H-bonds distances. In the dibenzyl derivative of triacanthine, the prenyl group is disordered in two positions in a ratio of 0.65:0.35, which makes it possible to fill voids in the crystal packing. The Hirshfeld surface analysis indicates that the most important contributions to the crystal packing are from H…H (about 57.9% and 51.4% for di- and tribenzyl derivatives respectively) and H…C/C…H (around 14.9% and 19.2%) interactions.
A Charcteristic Model of Cuproptosis-Associated Long Noncoding RNAs to Predict Prognosis and the Immunotherapy Response in Patients with Gastric Cancer
Authors: zhao tingting , Zhang Cui , Lin Huiyang , Liu Hui , Xuan Qijia 
Published: January 2023

Abstract
Background
Cuproptosis and lncRNAs are the focus of current research, which had been confirmed to play an important role in the development of tumor. Nevertheless, effects of cuproptosis-related lncRNAs on GC have been limited. The purpose of this study was to determine a characteristic model of cuproptosis-related lncRNAs to predict their prognostic role and therapeutic response in GC.
Methods
Transcriptome profiling data and clinical data from GC patients were available from the TCGA database. GC patients were randomly assigned to the training group and the testing group. In the training group, a risk prognostic model of cuproptosis-related lncRNAs was constructed by co-expression, univalent analysis, LASSO analysis and multivariate analysis, and the model was verified in the testing group. Supported by the risk score and clinical characteristics, we subsequently developed a mixed nomogram. Finally,immunotherapy response was evaluated by TMB and TIDE score.
Results
Based on previous literature, we collected 19 genes related to cuproptosis. Subsequently, 140 cuproptosis-related lncRNAs were available for consultation as a result of co-expression. The Cox model revealed and constructed five cuproptosis-related lncRNAs prognostic models(AC243829.4, AL353622.1, CMAHP, LINC01579, MIR194_2HG). Patients were subdivided into high-risk and low-risk groups based on a median risk score. The Kaplan-Meier survival curve and receiver operating characteristic curve revealed that the model had accurate predictive ability. Univariate and multivariate Cox regression analyses showed that the risk score was an independent prognostic factor. In addition, we used multivariate Cox regression to construct a mixed nomogram of the predictive power of prognostic markers. Most notably, patients with lower risk score had increased TMB score and decreased TIDE score, suggesting that these patients exhibited a better immune checkpoint blockade response.
Conclusions
The prognostic characteristic model based on cuproptosis-related lncRNAs has the potential to be laid down the survival, immune environment and immunotherapy efficacy of GC, which is helpful for clinical prediction and individualized treatment.
Voltage and small signal stability assessment of power systems under load and renewable energy sources uncertainties
Authors: Naidji Mourad , Boudour Mohamed 
Published: January 2023

Abstract
Due to the deregulation of the electricity market, power systems are showing increased uncertainties related to loads and renewable sources. Such uncertainties will involve the assessment of the impact of uncertain variables on the control and monitoring of the future power systems. Identification and classification of influential uncertain variables are imperative for power system stability assessment in future smart grid because they provide guidance for handling uncertainty for electrical system operators for management and securing the power grid operations with efficient control and monitoring. In this paper, a probabilistic analysis methodology is proposed for the assessment of the impact of critical uncertain variables on voltage and small-signal stability using quantitative sensitivity technique. The proposed methodology is carried out with different level of penetration of renewable sources and the impacts of influential variables are treated and discussed. The proposed methodology is performed using the modified IEEE 14-bus benchmark. The performances of the probability density function graphs for stability indexes are used for assessing their sensitivities.
FUNDC1-Induced Mitophagy Protects Spinal Cord Neurons against Ischemic Injury
Authors: Chen Dehui , Zhou Linquan , Chen Gang , Lin Taotao , Lin Jiemin , Zhao Xin , Li Wenwen , Guo Shengyu , Wu Rongcan , Wang Zhenyu , Liu Wenge 
Published: January 2023

AbstractLocal ischemia and hypoxia are the most important pathological processes in the early phase of secondary spinal cord injury (SCI), in which mitochondria are the main target of ischemic injury. Mitochondrial autophagy, also known as mitophagy, acts as a selective autophagy that specifically identifies and degrades damaged mitochondria, thereby reducing mitochondria-dependent apoptosis. Accumulating evidence shows that the mitophagy receptor, FUN14 domain-containing 1 (FUNDC1), plays an important role in ischemic injury, but the role of FUNDC1 in SCI has not been reported. In this study, we aimed to investigate whether FUNDC1 can enhance mitophagy and inhibit neuronal apoptosis in the early stage of SCI. In a rat SCI model, we found that FUNDC1 overexpression enhanced neuronal autophagy and decreased neuronal apoptosis in the early stage of injury, thereby reducing spinal cord damage. In vitro studies showed that the neuroprotective effects of FUNDC1 were achieved by inhibiting mitochondria-dependent apoptosis and improving mitochondrial function. In addition, FUNDC1 enhanced mitophagy. The protective effects of FUNDC1 against apoptosis and mitochondrial dysfunction were reversed by 3-methyladenine (3-MA), an autophagy inhibitor. Taken together, our results confirm that FUNDC1 can protect against neuronal loss after SCI by inducing mitophagy, inhibiting mitochondria-dependent apoptosis, and improving mitochondrial function.
The application of a metal-organic framework based on copper (MOF-199) and its modified form (G@MOF-199) in the four-component synthesis of spiro indenoquinoxaline derivatives
Authors: hojati seyedeh fatemeh , amiri amirhassan , khaleghinasab faeze 
Published: January 2023

Abstract
The metal-organic framework based on copper (MOF-199) has been synthesized and loaded on the surface of the graphene sheets to give G@MOF-199 nanocomposite and characterized using FT-IR, SEM, and TEM analyses. The catalytic application of MOF-199 and its modified form (G@MOF-199) was investigated in the four-component synthesis of 2'-aminospiro[indeno[1,2-b]quinoxaline-11,4' -[4'H] pyran]-3'-carbonitrile derivatives and compared together. It was found that the G@MOF-199 nanocomposite is reusable and its catalytic activity is more than MOF-199. High yields, short reaction times, mild reaction conditions, and easy work-up procedure, in combination with stability, efficiency, and non-toxicity of the catalysts are noteworthy advantages of both methods.
Pure pompon structured Co-Mo alloy electro-deposited from ethylene glycol solution and used as electrocatalysts for hydrogen evolution reaction
Authors: He Xinkuai , Hu Zousi , Zou Qingtian , Yang Jingjing , Wu Luye Y. 
Published: January 2023

Abstract

Design, development and fabrication of electrode materials with low-cost, excellent inherent electrocatalytic activity and stability are one of the most key challenges in the electrochemical water splitting technique. We employ deposition technique to fabricate the pure pompon structured Co-Mo alloy electrocatalysts from ethylene glycol (EG) solution, in which the pure pompon structure presents highly inherent electrocatalytic activity for hydrogen evolution reaction (HER). The co-deposition behavior of Co(II) and Mo(VI) and Co-Mo electro-crystallization mechanism in ethylene glycol(EG) are recorded using cyclic voltammetry (CV) and chronoamperometry (CA). These results indicate that the Co-Mo co-deposition is representative induced deposition; Co(II) species can facilitate Co-Mo co-deposition, inversely, Mo(VI) species can inhibit Co(II) reduction and the effect can be enhanced as Mo(VI) concentration increases. Additionally, Co-Mo co-deposition in EG takes place through an instantaneous nucleation and diffusion-controlled three-dimensional growth mechanism. Co-Mo deposits with various Mo contents and different microstructures can be obtained from the EG solution. SEM micrographs present that the Co-Mo deposits with 1.56 wt.% Mo present a pure pompon microstructure. Benefiting from the composition engineering by alloying with Mo, as well as the simultaneous presence of a suitable pompon structure, Co-Mo deposits with 1.56 wt.% exhibits prominent electrocatalytic durability and activity with a η10 of 84 mV for HER in a 1.0 M KOH.