bluuebunny/crossref_metadata_2025_split huggingface dataset:
Silk consumption and dressing practices in late-medieval Catalonia: the cases of Barcelona and Vic (1400–1460)
Authors: Palarea Marimón Aina 
Published: January 2025

Abstract
This article examines how consumer preferences towards silk fabrics changed in Catalonia over the course of the first sixty years of the 15th century. It argues that during the first half of the 15th century silk became a luxury fabric for the wealthiest households of Catalan urban society. This change was triggered by the crisis of Europe's most prestigious manufacturing centres of high-quality woollens. Moreover, this article also claims that the adoption of silk as Catalonia's newest luxury fabric entailed a transition from lighter and plain silks to more expensive and elaborate silk fabrics. Finally, it connects this sumptuary shift to the technological development of the Italian silk industry and its later diffusion in Europe.
The National Symphony Orchestra of Ghana plays Ghanaian Classics: negotiating multiple identities through highlife music
Authors: Nii-Dortey Moses , Akwetteh Laryea 
Published: January 2025

AbstractFifty-six years after its establishment, the Ghana National Symphony Orchestra in 2015 recorded its debut album Ghanaian Classics at the Institute of African Studies, University of Ghana, Legon. Despite the overwhelming challenge of low patronage of art music in Africa generally, the choice of repertoire and composers for this historic album was largely drawn from the Ghanaian popular music domain. This paper investigates the extent to which the album recording and launch represented a deliberate attempt by the orchestra to negotiate its multiple identities through Ghanaian highlife music and musicians. We argue that the album recording, the choice of the highlife genre and artists featured on the CD, the instrumentation and the venues for the recording and launch were all a deliberate attempt to de-escalate the elitist label the Ghana National Symphony Orchestra has carried right from its inception and to court a larger following from the Ghanaian populace as a national cultural asset.
Starting a Prehospital Medication for Opioid Use Disorder Program
Authors: Seaberg David C. , McKinnon Jamie , Haselton Lyn , Gallo Doug , Kolb Jason , Moran Mary , Vellanki Suman , Raubenolt Amy , Simon Erin , Jouriles Nicholas 
Published: January 2025

AbstractBackground:Over 2.7 million people have an opioid use disorder (OUD). Opioid-related deaths have steadily increased over the last decade. Although emergency department (ED)-based medication for OUD (MOUD) has been successful in initiating treatment for patients, there still is a need for improved access. This study describes the development of a prehospital MOUD program.Methods:An interdisciplinary team expanded a MOUD program into the prehospital setting through the local city fire department Quick Response Team (QRT) to identify patients appropriate for MOUD treatment. The QRT consisted of a paramedic, social worker, and police officer. This team visited eligible patients (i.e., history of an opioid overdose and received prehospital care the previous week). The implementation team developed a prehospital MOUD protocol and a two-hour training course for QRT personnel. Implementation also required a signed contract between local hospitals and the fire department. A drug license was necessary for the QRT vehicle to carry buprenorphine/naloxone, and a process to restock the vehicle was created. Pamphlets were created to provide to patients. A clinical algorithm was created for substance use disorder (SUD) care coordinators to provide a transition of care for patients. Metrics to evaluate the program included the number of patients seen, the number enrolled in an MOUD program, and the number of naloxone kits dispensed. Data were entered into iPads designated for the QRT and uploaded into the Research Electronic Data Capture (REDCap) program.Results:Over the six-month pilot, the QRT made 348 visits. Of these, the QRT successfully contacted 83 individuals, and no individuals elected to be evaluated for new MOUD treatment. Nine fatal opioid overdoses occurred during the study period. A total of 55 naloxone kits were distributed, and all patients received MOUD information pamphlets.Conclusions:A prehospital MOUD program can be established to expand access to early treatment and continuity of care for patients with OUD. The program was well-received by the local city fire department and QRT. There is a plan to expand the prehospital MOUD program to other local fire departments with QRTs.
Factors correlated with demoralization among cancer patients: A systematic review and meta-analysis
Authors: Tang Wen-zhen , Cheng Shi-li , Mangantig Ernest , Yulita Hanum P Iskandar , Jia Kui , Yusuf Azlina 
Published: January 2025

Abstract

Objectives
Demoralization isa common psychological problem in cancer patients. The purpose of this study is to systematically evaluate the correlated factors of demoralization among cancer patients. We also summarized the available evidence, effect estimates, and the strength of statistical associations between demoralization and its associated factors.

Methods
We systematically searched PubMed, Web of Science, CINAHL, Embase, the Cochrane Library, PsycINFO, and 2 electronic databases to identify studies published up to October 2023 with data on the correlates of demoralization. Two researchers independently reviewed references, extracted data, and assessed data quality. Meta-analysis was performed using R4.1.1 software.

Results
Thirty-eight studies were included in this meta-analysis. For the most studied sociodemographic correlates, demoralization was negatively correlated with income (z = −0.29, 95% CI: −0.51, −0.02), education (z = − 0.11, 95% CI: − 0.16, −0.05), and age (z = −0.45, 95%CI: −0.75, −0.01). For the most studied clinical correlates, demoralization was positively correlated with symptom burden (z = 0.37, 95% CI: 0.22, 0.50) and negatively correlated with quality of life (z = −0.40, 95% CI: −0.54, −0.24). For the most studied psychosocial correlates, demoralization was negatively correlated with social support (z = −0.39, 95% CI: −0.51, −0.26) and positively correlated with anxiety (z = 0.65, 95% CI: 0.56, 0.73), depression (z = 0.61, 95% CI: 0.54, 0.67), and suicidal ideation (z = 0.48, 95% CI: 0.34, 0.60).

Significance of results
Demoralization showed either positive or negative associations with sociodemographic, clinical, and psychological variables. More research is needed to explore the underlying mechanisms to develop effective interventions. This review provides information on the factors associated with demoralization in cancer patients, which can be used to inform strategies for clinical care providers.
Situated Civility: Anna Julia Cooper and Hannah Gadsby on Politeness and Public-Mindedness
Authors: Schaap Andrew , Tønder Lars 
Published: January 2025

Abstract
In public life, the problem of civility is often presented as a choice over whether citizens should recover social norms of civility to sustain politics in the face of polarization or else contest demands for civility to politicize social inequalities. Political theorists often respond by treating this as an epistemological problem requiring conceptual clarification. By distinguishing between civility as politeness and civility as public-mindedness, for instance, they promise to clarify when it is appropriate to conform to social norms and when it might be morally permissible to be rude or disrespectful. While valid in its own terms, such an approach presupposes an impoverished conception of both the subject and the politics of civility. Rather than ask when and why we should choose to be civil (or not), in this article we ask: what is produced when citizens are civil or uncivil within a given situation? We consider this by turning to two feminist interlocutors: Anna Julia Cooper and Hannah Gadsby. Engaging with their reflections on and interventions within situations in which civility rises to the level of explicit attention provides the basis for a more adequate understanding of the subject of civility. Cooper and Gadsby each highlight how the subject does not simply choose whether to conform to social norms but is both constituted by the situation within which they act while also constituting the situation of which they are a part. This opens the way to a more adequate understanding of the politics of civility. As an embodied negotiation of social norms and political principles, Cooper and Gadsby show how this involves reading situations, expanding situations to interpellate others, and disclosing the limits of a situation.
Microclimate Driven Grassland Greenness Asymmetry Between West‐ and East‐ Facing Slopes on the Tibetan Plateau
Authors: Xie Jiangliu , Yan Xinyu , Chen Rui , Yang Yajie , Cao Yungang , Jian Yi , Yin Gaofei 
Published: January 2025

AbstractSlope orientation creates microclimate by modulating water and heat flux between the land surface and the atmosphere, thereby regulating vegetation growth and its response to background climate change. However, the potential asymmetry in vegetation greenness between west‐ and east‐facing slopes remains underexplored. Analyzing the normalized difference vegetation index derived from Landsat reflectances in the Tibetan Plateau (TP) grassland, we identified that west‐facing slopes were greener than east‐facing slopes in the western TP, while the opposite appeared in the eastern TP. We also detected a stronger greening trend on west‐ than east‐ facing slopes over the entire TP grassland from 1991 to 2020. These disparities result from distinct microclimates on the two contrasting slopes: west‐facing slopes tend to be wetter and colder than east‐facing slopes under similar background climate. Our findings underscore the crucial role of slope orientation in shaping vegetation greenness and its response to climate change.
Evaluating Cloud Properties at Scott Base: Comparing Ceilometer Observations With ERA5, JRA55, and MERRA2 Reanalyses Using an Instrument Simulator
Authors: McDonald A. J. , Kuma P. , Panell M. , Petterson O. K. L. , Plank G. E. , Rozliaiani M. A. H. , Whitehead L. E. 
Published: January 2025

AbstractThis study compares CL51 ceilometer observations made at Scott Base, Antarctica, with statistics from the ERA5, JRA55, and MERRA2 reanalyses. To enhance the comparison we use a lidar instrument simulator to derive cloud statistics from the reanalyses which account for instrumental factors. The cloud occurrence in the three reanalyses is slightly overestimated above 3 km, but displays a larger underestimation below 3 km relative to observations. Unlike previous studies, we see no relationship between relative humidity and cloud occurrence biases, suggesting that the cloud biases do not result from the representation of moisture. We also show that the seasonal variation of cloud occurrence and cloud fraction, defined as the vertically integrated cloud occurrence, are small in both the observations and the reanalyses. We also examine the quality of the cloud representation for a set of weather states derived from ERA5 surface winds. The variability associated with grouping cloud occurrence based on weather state is much larger than the seasonal variation, highlighting weather state is a strong control of cloud occurrence. All the reanalyses continue to display underestimates below 3 km and overestimates above 3 km for each weather state. But the variability in ERA5 statistics matches the changes in the observations better than the other reanalyses. We also use a machine learning scheme to estimate the quantity of supercooled liquid water cloud from the ceilometer observations. Ceilometer low‐level supercooled liquid water cloud occurrences are considerably larger than values derived from the reanalyses, further highlighting the poor representation of low‐level clouds in the reanalyses.
Late Jurassic Initial Development of a Salt‐Dominated Fold‐And‐Thrust Belt: The Inverted Passive Margin of the Eastern Alps (Austria)
Authors: Fernandez O. , Ortner H. , Munday W. E. H. , Moser M. , Sanders D. , Grasemann B. , Leitner T. 
Published: January 2025

AbstractThe Northern Calcareous Alps (Eastern Alps, Austria) represent a well‐preserved example of the early stages of inversion of a salt‐bearing passive margin, which occurred in a fully submarine setting. Late Jurassic shortening led to widespread thrusting and folding that nucleated preferentially, although not exclusively, along salt structures developed during the Triassic passive‐margin stage. The presence of a highly effective basal décollement permitted the propagation of deformation without generalized uplift in the area, which was limited to thrusts, folds and squeezed salt structures. The development of individual structures was controlled by the orientation of pre‐existing salt structures, the thickness of supra‐salt stratigraphy, the lateral propagation of deformation, and, possibly, the redistribution of salt within salt structures prior to contraction and the influence of sub‐salt basement faults. Syn‐tectonic sediments make it possible to reliably reconstruct the timing of structural inversion. These same sediments were in turn controlled by structural evolution, with depocenters developing roughly parallel to the inverting structures. The structures documented here are evidence for Late Jurassic shortening across the central Eastern Alps, totaling a few to few tens of kilometers. This is the first systematic description of structures of Late Jurassic age in the Eastern Alps and provides a framework within which to understand the abundance of syn‐tectonic deposits of this age in the area. Particular attention is paid to the Totengebirge–Trattberg contractional system, an outstandingly long set of structures, whose continuity and significance has gone previously unrecognized.
Exosome-based targeted delivery of NF-κB ameliorates age-related neuroinflammation in the aged mouse brain
Authors: Lee Chae-Jeong , Jang Seung Hyun , Lim Jiwoo , Park Hyunju , Ahn So-Hee , Park Seon Young , Seo Hyangmi , Song Soo-Jin , Shin Jung-A , Choi Chulhee , Gee Heon Yung , Choi Youn-Hee 
Published: January 2025

Abstract
Neuroinflammation, a significant contributor to various neurodegenerative diseases, is strongly associated with the aging process; however, to date, no efficacious treatments for neuroinflammation have been developed. In aged mouse brains, the number of infiltrating immune cells increases, and the key transcription factor associated with increased chemokine levels is nuclear factor kappa B (NF-κB). Exosomes are potent therapeutics or drug delivery vehicles for various materials, including proteins and regulatory genes, to target cells. In the present study, we evaluated the therapeutic efficacy of exosomes loaded with a nondegradable form of IκB (Exo-srIκB), which inhibits the nuclear translocation of NF-κB to suppress age-related neuroinflammation. Single-cell RNA sequencing revealed that these anti-inflammatory exosomes targeted macrophages and microglia, reducing the expression of inflammation-related genes. Treatment with Exo-srIκB also suppressed the interactions between macrophages/microglia and T and B cells in the aged brain. We demonstrated that Exo-srIκB successfully alleviates neuroinflammation by primarily targeting activated macrophages and partially modulating the functions of age-related interferon-responsive microglia in the brain. Thus, our findings highlight Exo-srIκB as a potential therapeutic agent for treating age-related neuroinflammation.
V̇O2peak estimation in people with overweight and obesity before and after a 14-week lifestyle intervention
Authors: Hansen Mikkel Thunestvedt , Husted Karina , Modvig Johanne Louise , Lange Kristine Kjær , Weinreich Cecilie Moe , Tranberg Cathrine , Rømer Tue , Ingersen Arthur , Dela Flemming , Helge Jørn Wulff 
Published: January 2025

Abstract

Purpose
This study aimed to investigate the validity and applicability of a non-exercise estimation of cardiorespiratory fitness using resting seismocardiography (SCG eV̇O2peak) in people with overweight and obesity before and after a 14-week lifestyle intervention.

Methods
The study was carried out at a Folk high school that offers 14-week courses on lifestyle changes where participants live at the school and voluntarily participate in daily lectures and activities. Sixty-seven men and women with age and body mass index between 18 and 70 years and 25–50 kg·m–2 were tested at baseline, and 52 had a follow-up test after 14 weeks. Testing included the determination of anthropometric variables, an SCG eV̇O2peak at supine rest, and a gold standard V̇O2peak test on a cycle ergometer until voluntary exhaustion.

Results
Agreement analysis for V̇O2peak at baseline (n = 67, SCG eV̇O2peak: 26.9 ± 1.9 ml·min–1·kg–1, V̇O2peak: 26.6 ± 1.6 ml·min–1·kg–1, mean ± 95% confidence interval) showed a bias of 0.3 ± 1.0 ml·min–1·kg–1 with 95% limits of agreement (LoA) ranging ± 9.8 ml·min–1·kg–1. A Pearson’s correlation of r = 0.78 (p < 0.0001) and a standard error of estimate (SEE) of 5.0 ml·min–1·kg–1 were found between methods. At follow-up (n = 52), body mass was reduced by 6.6 ± 1.4 kg (p < 0.0001). V̇O2peak increased by 3.3 ± 0.9 ml·min–1·kg–1 and 175 ± 78 ml·min–1 and SCG eV̇O2peak by 2.6 ± 0.8 ml·min–1·kg–1 and 93 ± 76 ml·min–1 (two-way ANOVA repeated measure: intervention p < 0.0001, method p = 0.939 and interaction p = 0.125, relative V̇O2peak). A Pearson’s correlation of r = 0.37 (p < 0.05) was found between changes in relative V̇O2peak but not for absolute V̇O2peak r = 0.10 (p = 0.402).

Conclusions
The SCG method is accurate for estimating V̇O2peak and appropriate for detecting group changes in both relative and absolute V̇O2peak following a lifestyle intervention in people with overweight and obesity. Furthermore, the method can detect individual changes in V̇O2peak but not independently of body mass changes. Yet, the applicability is still limited by the relatively large variation in LoA and SEE.
Dehydrocorydaline maintains the vascular smooth muscle cell contractile phenotype by upregulating Spta1
Authors: Dang Yuan-ye , Chen Cui , Wei Qiu-fen , Gao Li-feng , Zhang Shun-chi , Li Yong-xian , Dai Xiao-yan 
Published: January 2025

Abstract
Vascular smooth muscle cell (VSMC) phenotypic switching plays a crucial role in the initiation and progression of atherosclerosis. Dehydrocorydaline (DHC), a major active component of the traditional Chinese herbal medicine Rhizoma Corydalis, exhibits diverse pharmacological effects. However, its impact on VSMCs remains largely unknown. This study aims to investigate the effects and underlying mechanisms of DHC in phenotypic switching of VSMCs. Our study revealed that DHC increased the mRNA and protein levels of rat VSMC contractile phenotype markers, such as calponin 1 (Cnn1), myosin heavy chain (Myh11, SM-MHC), smooth muscle 22α (Sm22α), and alpha-smooth muscle actin (Acta2, α-SMA) in a time- and dose-dependent manner. Additionally, DHC inhibited platelet-derived growth factor-BB-induced VSMC proliferation and migration. In Apoe

−/−
mice, DHC treatment resulted in reduced carotid plaque areas and macrophage infiltration, along with increased contractile phenotype marker expression. RNA sequencing analysis revealed a significant upregulation of spectrin alpha, erythrocytic 1 (Spta1) in DHC-treated rat VSMCs. Strikingly, Spta1 knockdown effectively negated the increase in contractile phenotype marker expression in VSMCs that was initially prompted by DHC. Therefore, DHC preserves the VSMC contractile phenotype through Spta1, thereby attenuating carotid artery atherosclerotic plaques in Apoe

−/−
mice. This study provides evidence supporting the potential use of Chinese herbal medicines, particularly those containing DHC such as Rhizoma Corydalis, in the treatment of atherosclerotic cardiovascular disease, thus expanding the clinical application of such herbal remedies.
Polycystin-1 regulates tendon-derived mesenchymal stem cells fate and matrix organization in heterotopic ossification
Authors: Xu Yi Li , Huang Mei , Zhang Yang , Su Xin Ying , Huang Min , Zou Nan Yu , Jiao Yu Rui , Sun Yu Chen , Liu Ling , Lei Yong Hua , Li Chang Jun 
Published: January 2025

Abstract
Mechanical stress modulates bone formation and organization of the extracellular matrix (ECM), the interaction of which affects heterotopic ossification (HO). However, the mechanically sensitive cell populations in HO and the underlying mechanism remain elusive. Here, we show that the mechanical protein Polysyctin-1 (PC1, Pkd1) regulates CTSK lineage tendon-derived mesenchymal stem cell (TDMSC) fate and ECM organization, thus affecting HO progression. First, we revealed that CTSK lineage TDMSCs are the major source of osteoblasts and fibroblasts in HO and are responsive to mechanical cues via single-cell RNA sequencing analysis and experiments with a lineage tracing mouse model. Moreover, we showed that PC1 mediates the mechanosignal transduction of CTSK lineage TDMSCs to regulate osteogenic and fibrogenic differentiation and alters the ECM architecture by facilitating TAZ nuclear translocation. Conditional gene depletion of Pkd1 or Taz in CTSK lineage cells and pharmaceutical intervention in the PC1-TAZ axis disrupt osteogenesis, fibrogenesis and ECM organization, and consequently attenuate HO progression. These findings suggest that mechanically sensitive CTSK-lineage TDMSCs contribute to heterotopic ossification through PC1-TAZ signaling axis mediated cell fate determination and ECM organization.
Exocyst complex component 1 (Exoc1) loss in dormant oocyte disrupts c-KIT and growth differentiation factor (GDF9) subcellular localization and causes female infertility in mice
Authors: Nguyen Chi Lieu Kim , Kuba Yumeno , Le Hoai Thu , Shawki Hossam Hassan , Mikami Natsuki , Aoki Madoka , Yasuhara Nanako , Suzuki Hayate , Mizuno-Iijima Saori , Ayabe Shinya , Osawa Yuki , Fujiyama Tomoyuki , Dinh Tra Thi Huong , Ishida Miyuki , Daitoku Yoko , Tanimoto Yoko , Murata Kazuya , Kang Woojin , Ema Masatsugu , Hirao Yuji , Ogura Atsuo , Takahashi Satoru , Sugiyama Fumihiro , Mizuno Seiya 
Published: January 2025

Abstract
A limited number of female germ cells support reproduction in many mammals. The follicle, composed of oocytes and supporting granulosa cells, forms the basis of oogenesis. Crosstalk between oocytes and granulosa cells is essential for the formation, dormancy, re-awakening, and maturation of oocytes. The oocyte expresses c-KIT and growth differentiation factor-9 (GDF-9), which are major factors in this crosstalk. The downstream signalling pathways of c-KIT and GDF-9 have been well-documented; however, their intra-oocyte trafficking pathway remains unclear. Our study reveals that the exocyst complex, a heterotetrameric protein complex important for tethering in vesicular transport, is important for proper intra-oocyte trafficking of c-KIT and GDF9 in mice. We found that depletion of oocyte-specific EXOC1, a component of the exocyst complex, impaired oocyte re-awakening and cyst breakdown, and inhibited granulosa cell proliferation during follicle growth. The c-KIT receptor is localised on the oocyte plasma membrane. The oocyte-specific Kit conditional knockout mice were reported to exhibit impaired oocyte re-awakening and reduced oocyte cyst breakdown. GDF9 is a protein secreted extracellularly in the oocyte. Previous studies have shown that Gdf9 knockout mice impaired proliferation and granulosa cell multilayering in growing follicles. We found that both c-KIT and GDF9 abnormally stuck in the EXOC1-depleted oocyte cytoplasm. These abnormal phenotypes were also observed in oocytes depleted of exocyst complex members EXOC3 and EXOC7. These results clearly show that the exocyst complex is essential for proper intra-oocyte trafficking of c-KIT and GDF9. Inhibition of this complex causes complete loss of female fertility in mice. Our findings build a platform for research related to trafficking mechanisms of vital crosstalk factors for oogenesis.