bluuebunny/crossref_metadata_2025_split huggingface dataset:
Does cumulative adverse socioeconomic exposure mediate the association of maternal mental ill health at birth and adolescent mental ill health at age 17? An analysis of the Millennium Cohort Study
Authors: Sheldon Faye Helen , Barr Ben , Wickham Sophie 
Published: June 2023

BackgroundAdolescent mental health is a public health priority. Maternal mental ill health and adverse socioeconomic exposure (ASE) are known risk factors of adolescent mental ill health. However, little is known about the extent to which cumulative ASE over the life course mediates the maternal–adolescent mental health association, which this study aims to explore.MethodsWe analysed data from more than 5000 children across seven waves of the UK Millennium Cohort Study. Adolescent mental ill health was measured using the Kessler 6 (K6) and Strengths and Difficulties Questionnaire (SDQ) at age 17. The exposure was maternal mental ill health as measured by the Malaise Inventory at the child’s birth. Mediators were three measures of cumulative ASE defined by maternal employment, housing tenure and household poverty. Confounders measured at 9 months were also adjusted for, these were: maternal age, maternal ethnicity, household poverty, maternal employment, housing tenure, maternal complications during labour and maternal education. Using causal mediation analysis, we assessed the cumulative impact of ASE on the maternal–adolescent mental ill health relationship between birth and age 17.ResultsThe study found a crude association between mothers’ mental health at the child’s birth and mental health of their children at age 17, however, when adjusting for confounders this association was reduced and no longer significant. We did not find an association between cumulative exposure to maternal non-employment or unstable housing over the child’s life course and adolescent mental health, however, cumulative poverty was associated with adolescent mental ill health (K6: 1.15 (1.04, 1.26), SDQ: 1.16 (1.05, 1.27)). Including the cumulative ASE measures as mediators reduced the association between maternal and adolescent mental health, but only by a small amount.ConclusionsWe find little evidence of a mediation effect from cumulative ASE measures. Experiencing cumulative poverty between the ages of 3–14 was associated with an increased risk of adolescent mental ill health at age 17, suggesting actions alleviating poverty during childhood may reduce adolescent mental health problems.
Post-War Interventionism and Diplomatic Practice in Bosnia Herzegovina: Too Much or Too Little?
Authors: Minasi Nicola 
Published: June 2023

Abstract
After almost 30 years from the Dayton Agreement of 1995, time has come to appraise the successes and failures of interventionism in Bosnia and Herzegovina (BiH). By drawing on insights from a practitioner’s perspective, the article explores the dynamic of diplomatic action and offers a template to assess its (in)effectiveness. With time, rifts have emerged in the international community both in messaging and operational terms, which have reduced, rather than increased, the positive effects of concerted action. Moreover, whilst the Office of the High Representative (ohr) has been an important tool for reconstruction and peace-making, its role remains incompatible with the prospect of full European Union (EU) membership, thus becoming a divisive actor. At the same time the US and UK have come to see the ohr and other non-EU organisations, such as nato and the osce, as the main tools for a continued presence in the country, making overall cooperation more complicated. A “grand plan” is therefore needed to reunite the forces of the players of good will. This will require an arrangement for the winding up of the ohr, coupled with constitutional reform. To this end a new vision for BiH is necessary, both at the international and local level, to better spell out what a “European BiH” should really look like.
Insights on Satellite-Based IMERG Precipitation Estimates at Multiple Space and Time Scales for a Developing Urban Region in India
Authors: Ponukumati Padmini , Mohammed Azharuddin , Regonda Satish 
Published: June 2023

Abstract
Satellite-based rainfall estimates are a great resource for data-scarce regions, including urban regions, because of its finer resolution. Integrated Multi-satellitE Retrievals for GPM (IMERG) is a widely used product and is evaluated at a city scale for the Hyderabad region using two different ground truths, i.e., India Meteorological Department (IMD) gridded rainfall and Telangana State Development Planning Society (TSDPS) automatic weather station (AWS) measured rainfall. The IMERG rainfall estimates are evaluated on multiple spatial and temporal scales as well as on a rainfall event scale. Both continuous and categorical verification metrics suggest good performance of IMERG on the daily scale; however, relatively decreased performance was observed on the hourly scale. Underestimated and overestimated IMERG estimates with respect to IMD gridded rainfall and AWS measured rainfall, respectively, suggest the performance depends on type of ground truth. Unlike categorical metrics, RMSE and PBIAS have a pattern implying a systematic error with respect to rainfall amount. Further, sample size, diurnal variations, and season are found to have a role in IMERG estimates’ performance. Temporal aggregation of hourly to daily time scales showed the improved IMERG performance; however, no spatial-scale dependence was observed among zonewise and Hyderabad region–wise rainfall estimates. Comparison of raw and bias-corrected IMERG rainfall-based intensity–duration–frequency (IDF) curves with corresponding hourly rain gauge IDF curves showcases the value addition via simple bias correction techniques. Overall, the study suggests the IMERG estimates can be used as an alternative data source, and it can be further improved by modifying the retrieval algorithm.

Significance Statement
Many urban regions are typically data sparse, which limits scientific understanding and reliable engineering designs of various urban hydrometeorology-relevant tasks, including climatological and extreme rainfall characterization, flood hazard assessment, and stormwater management systems. Satellite rainfall estimates come as a great resource and Integrated Multi-satellitE Retrievals for GPM (IMERG) acts as a best alternative. The Hyderabad region, the sixth-largest metropolitan area in India, is selected to analyze the widely used satellite estimates, i.e., retrievals for GPM. The study observed inaccuracies in the IMERG estimates that varied with rainfall magnitudes and space and time scales; nonetheless, the estimates can be used as an alternative data source for decision-making such as whether rain exceeds a certain threshold or not.
Impacts of Marine Surface Pressure Observations from a Spaceborne Differential Absorption Radar Investigated with an Observing System Simulation Experiment
Authors: Privé N. C. , McLinden Matthew , Lin Bing , Moradi Isaac , Sienkiewicz Meta , Heymsfield G. M. , McCarty Will 
Published: June 2023

Abstract
A new instrument has been proposed for measuring surface air pressure over the marine surface with a combined active/passive scanning multichannel differential absorption radar to provide an estimate of the total atmospheric column oxygen content. A demonstrator instrument, the Microwave Barometric Radar and Sounder (MBARS), has been funded by the National Aeronautics and Space Administration for airborne test missions. Here, a proof-of-concept study to evaluate the potential impact of spaceborne surface pressure data on numerical weather prediction is performed using the Goddard Modeling and Assimilation Office global observing system simulation experiment (OSSE) framework. This OSSE framework employs the Goddard Earth Observing System model and the hybrid 4D ensemble variational Gridpoint Statistical Interpolation data assimilation system. Multiple flight and scanning configurations of potential spaceborne orbits are examined. Swath width and observation spacing for the surface pressure data are varied to explore a range of sampling strategies. For wider swaths, the addition of surface pressures reduces the root-mean-square surface pressure analysis error by as much as 20% over some ocean regions. The forecast sensitivity observation impact tool estimates impacts on the Pacific Ocean basin boundary layer 24-h forecast temperatures for spaceborne surface pressures that are on par with rawinsondes and aircraft and estimates greater impacts than the current network of ships and buoys. The largest forecast impacts are found in the Southern Hemisphere extratropics.
Synthesis and characterization of 4-pyridine-bridge polybenzimidazolefor proton exchange membranes
Authors: Rathwa Yashesh J , Chikhaliya Navin P 
Published: June 2023

A series of polybenzimidazoles (PBIs) incorporated main chain 4-pyridine bridge groups were synthesized from 4,4′-([4,4′-bipyridine]-2,6,-diyl)bis (benzene-1,2-diamine) which reacted with four different diacids like isophthalic acid,4,4′-Oxibis benzoic acid, 5-amino isophthalic acid and 2,5-pyridine dicarboxylic acid using polyphosphoric acid as solvent. A process termed dispersion polymerizationhas been developed to prepare PBIs.For the membranepreparation, 4-pyridine-bridge polybenzimidazole (Py-PBI) productswere re-dissolved in dimethyl sulfoxide and cast. The polymer structure characterization included FT-IR, UV, Powder XRD, Water Uptake, Swelling Ratio, Ion exchange capacity, Acid doping, Acid leaching, Oxidative stability, and Polymer inherent viscosity find out by using Ubbelohde viscometer whilethermal stability assessments via thermogravimetric analysis. The Py-PBI-based polymer electrolyte membranes’ mechanical properties measurement showed that the 4-pyridine-bridge PBIs membranes were flexible, thermally stable, and mechanically strong when compared with conventional PBI. The current-voltage (I-V) characteristics of the 4-Py-PBI membrane show that the conductivity of the 4441P membrane is 0.546 S cm−1.
Towards time-domain modelling of wheel/rail noise: Effect of the dynamic track model
Authors: Theyssen Jannik 
Published: June 2023

Transient events in railway rolling noise, such as the characteristic impulsive noise at switches and crossings, can significantly contribute to the perceived annoyance, despite being difficult to detect in the standard frequency-domain methods to analyse rolling noise. Studying these transient effects and their perception requires predicting the noise in the time domain. While several time-domain approaches exist for predicting the dynamic interaction of wheel and rail, predicting the associated rolling noise with adequate accuracy is computationally costly. The lack of a model for transient noise and the need for studying its perception was recently identified. Aiming for a comprehensive time-domain radiation model that includes the wheel and track contributions to rolling noise, this work focuses on the track radiation. The modelling approach taken here is based on a 2.5D formulation for the acoustic radiation and moving Green’s functions in the air. The computational cost, which lies mainly in the 2.5D BE calculations, is addressed by pre-calculating acoustic transfer functions. These transfer functions can be combined with different dynamic track models. Different dynamic track models in turn affect radiated sound field in different ways. Here, the sound fields produced by six different track models are compared, including different support types and analytical and numerical rail models. Several descriptors of the sound field are analysed. In terms of the radiated sound power and radiation efficiency, modelling the rail as a simple beam leads to similar results as elaborate numerical models up to about 5 kHz. In terms of the track-side sound pressure, simple beam models can provide similar results only up to 2.5 kHz. Euler-Bernoulli (E-B) beams seem unfit for time-domain predictions of the radiated noise as they over-estimate the bending wave speed at high frequencies. The results also show that the standard track decay rate (TDR) and the decay of acoustic sound pressure along the track are comparable.
Anxiety exacerbation in a patient with chronic myeloid leukemia receiving dasatinib and venlafaxine
Authors: Bell Christopher , Signorelli Jessie , Hobbs Gabriela 
Published: June 2023

Introduction Tyrosine kinase inhibitor (TKI) use leads to near-normal life expectancy in patients with chronic myeloid leukemia (CML); unfortunately for some patients, adverse drug effects (ADEs) and medication burden associated with TKI therapy can lead to decreased quality of life. Additionally, TKIs have drug interactions that may negatively impact patients’ management of co-morbidities or lead to increased ADEs. Case report A 65-year-old female with a history of anxiety treated and controlled with venlafaxine experienced increased and resistant anxiety and insomnia after starting dasatinib for CML. Management and outcome On dasatinib, the patient experienced worsening anxiety and insomnia. The stress of a new leukemia diagnosis, drug interactions, and ADEs from dasatinib were considered possible causes. Dose adjustments to dasatinib and venlafaxine were made to control the patient’s symptoms. However, the patient’s symptoms did not resolve. After being on dasatinib for 2.5 years, the patient discontinued TKI therapy due to being in a deep molecular remission and given ongoing challenges managing anxiety. Within 4 months of stopping dasatinib, the patient reported an improvement in anxiety and overall emotional wellbeing. She continues to feel better and remains in a complete molecular remission 20 months off treatment. Discussion This case demonstrates a possible previously unknown drug interaction with dasatinib as well as a possible rarely reported ADE of dasatinib. Additionally, it highlights the difficulties patients with psychiatric disorders may face on TKI therapy and challenges providers may have in identifying rare psychiatric ADEs, thus emphasizing the need for documentation of these types of cases.
Real-world considerations for the rapid prototyping and manufacture of a ventilator for the COVID-19 pandemic
Authors: Wong Judith Ju Ming , Loke Fiona Wei Ling , Tan Herng Lee , Quah Jessica Lishan , Cheong Wai Chye , Khan Shariq Ali , Thomas Biju , Phua Ghee Chee , Chan Derrick Wei Shih 
Published: June 2023

Background In the COVID-19 pandemic, ventilators vital to keeping infected patients alive, were in short supply globally. Our aim was to rapidly prototype and implement production of basic ventilators to serve the local and regional needs in this emergency situation. Methods We adopted a supply-to-design approach, estimating the potential demand for ventilator units and sourcing for common off-the-shelf components available in the estimated quantities, to assemble ventilator units which met the essential requirements for clinical use. We determined the minimum requirements of a basic ventilator based on published specifications and clinician input. Building the ventilator involved interdisciplinary collaboration (between clinicians, industry, hospital innovation engineers and government partners), prototyping and repeated iterations, bench testing, animal testing, regulatory processes, ISO13485 quality management processes, licensing and user acceptability testing. Results We prototyped a limited feature ventilator to supplement hospital ventilators which could be manufactured in sufficient numbers within a short span of time from easily available component parts. Developed with close attention to clinician user input with compliance to ISO standards and quality management processes where possible, this ventilator system was composed of coupled resuscitation bags, motor systems, and pressure and flow sensors capable of delivering ventilator breaths within safe and clinically important targets. This system is functional on ambient air with or without low pressure oxygen supplementation. User feedback cited size, alarms and intuitiveness of controls as potential areas for improvement. Conclusions Further modification based on user acceptability testing results are needed to refine the usability of this limited feature ventilator.
A celebration of the work of Richard Cook, MD: A pioneer in understanding accidents, safety, human factors, and resilience
Authors: O'Connor Michael F. , Woods David , Perry Shawna J. , Patterson Emily S. , Nunnally Mark E. , Nemeth Christopher , Fairbanks Rollin J. (Terry) , Donchin Yoel , Bitan Yuval 
Published: June 2023

Dr. Richard Cook was a physician, educator, scholar, and researcher. He was a brilliant thinker and writer. Richard's CV lists 41 peer reviewed publications, 39 conference proceedings, 6 technical reports, 30 books/book chapters that were cited about 10,000 times (as of September 2022). Richard has excelled in multiple careers and was remarkably giving of his time, devoting 100s of thousands of hours of his life presenting, debating, corresponding, mentoring, and challenging the world, in formal and informal settings, to mature toward more complex, realistic thinking about the world as a sociotechnical entity. Our community recognizes him mainly for his key role in the start and expansion of the patient safety movement. This paper presents quintessence from a panel session that honors Richard’s work. The 7 panelists and moderator present Richard’s legacy, introduce varied aspects of his work, and consider how we can take his legacy forward to cope with future challenges. It is a moment to step back, remind ourselves of patient safety’s evolution from the 90’s until today, the power of resilience for the future of healthcare complex systems, and how to build momentum that can succeed at scale.
Prediction of Breast Self-Examination Behavior Among Omani Undergraduate Students Using Champion's Health Belief Model
Authors: Mohanmmed Wali Shakhman Lina , Arulappan Judie 
Published: June 2023

Introduction Breast cancer (BC) is a most common and frequently occurring malignancy of women worldwide. Breast self-examination (BSE) is important for the early detection and prevention of BC and to limit the morbidity and mortality. Young students are ideal people to understand and motivate other women to perform BSE. Objective BSE behavior of undergraduate students was predicted using Champion's Health Belief Model Scale (CHBMS). Methods A descriptive cross-sectional design was adopted. This study was conducted in all nine colleges of Sultan Qaboos University, , Oman. Three-hundred eighty-one female undergraduate students were selected through convenient sampling technique. The health belief towards BSE was predicted using CHBMS. Results The mean and SD of beliefs about the benefits of performing BSE showed 10.84 and 3.2, respectively. Mean and SD of confidence in performing BSE indicated 56.24 and 10.8. Likewise, the mean and SD of barriers in performing BSE are 13.58 and 4.2. Source of information is found to be a statistically significant predictor of barrier in performing BSE at p < .05. Conclusion If the self- confidence of women in performing BSE improves, the women will uptake BSE more frequently thereby they can be prevented from developing the adverse consequences of advanced stages of breast cancer.
Evaluation of Schlemm’s canal with swept-source optical coherence tomography in primary angle-closure disease
Authors: Ding Xuming , Huang Lulu , Peng Cheng , Xu Li , Liu Yixin , Yang Yijie , Wang Ning , Gu Mengyang , Sun Chengyang , Wu Yue , Guo Wenyi 
Published: June 2023

Abstract
Purpose
To perform an in vivo evaluation of the changes in Schlemm’s canal (SC) among patients with primary angle-closure disease (PACD) using swept-source optical coherence tomography (SS-OCT).

Methods
Patients diagnosed with PACD who had not undergone surgery were recruited. The SS-OCT quadrants scanned herein included the nasal and temporal sections at 3 and 9 o’clock, respectively. The diameter and cross-sectional area of the SC were measured. A linear mixed-effects model was performed to analyze the effects of parameters on the SC changes. The hypothesis of interest was related to the angle status (iridotrabecular contact, ITC/open angle, OPN), which was further explored with pairwise comparisons of the estimated marginal means (EMMs) of the SC diameter and SC area. In the ITC regions, the relationship between the trabecular-iris contact length (TICL) percentage and SC parameters was also studied by a mixed model.

Results
A total of 49 eyes of 35 patients were included for measurements and analysis. The percentage of observable SCs in the ITC regions was only 58.5% (24/41), whereas it was 86.0% (49/57) in the OPN regions (χ2 = 9.44, p = 0.002). ITC was significantly associated with a decreasing SC size. The EMMs for the diameter and cross-sectional area of SC at the ITC and OPN regions were 203.34 μm versus 261.41 μm (p = 0.006) and 3174.43 μm2 versus 5347.63 μm2 (p = 0.022), respectively. Sex, age, spherical equivalent refraction, intraocular pressure, axial length, extent of angle closure, history of acute attack and treatment with LPI were not significantly associated with SC parameters. In the ITC regions, a larger TICL percentage was significantly associated with a decrease in SC diameter and area (p = 0.003 and 0.019, respectively).

Conclusions
The morphologies of SC could be affected by the angle status (ITC/OPN) in patients with PACD, and ITC was significantly associated with a decreasing SC size. These changes in SC as described by OCT scans might help to elucidate the progression mechanisms of PACD.
Mothers’ lived experience of caring for children with inborn errors of amino acid metabolism
Authors: Shirdelzade Sara , Ramezani Monir , Eshraghi Peyman , Heydari Abbas 
Published: June 2023

Abstract
Background
Inborn errors of amino acid metabolism are chronic conditions that have many sequels. Mothers of these children are facing different challenges which are underdetermined. This study was done to explore lived experience of mothers caring for these children.

Methods
This is an interpretive phenomenology with van Manen’s approach which has 6 steps. Data were gathered by convenience and purposeful sampling. Nine mothers with different experiences were interviewed and the interviews were audiotaped.

Results
Six final themes were revealed from the exploring mothers’ experiences including the future tied to the past, psychosis in the shadow of a lost ideal child, rebellion and blaming, the ways of escaping difficulties, self-forgetting in the shadow of full-time care, passing difficulties in the duality of hope-hopelessness, caring in a continuum of isolation-socialization.

Conclusion
Mothers have multiple challenges in taking care of their children, especially psychologically and financially. So, nurses must plan programs for helping mothers of children with inborn errors of amino acid metabolism to reduce the effects of disease on mothers and consequently the children and the whole family.