bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gain scheduling control of aero-engine based on mixing polynomial LPV synthesis
Authors: Shen Bin , Xiao Lingfei , Ye Zhifeng 
Published: January 2023

Abstract
A full envelope LMI-based multi-region linear parameter-varying power controller is designed for a turbofan engine in this paper. According to the characteristics of aero-engine model, three scheduling variables are divided into two groups firstly, and then part of them are partitioned, rather than all scheduling variables are partitioned directly as the usual multi-region LPV control. The polynomial LPV model of aero-engine is established under a specific flight condition. An explicit LPV controller by gridding method based on parameter-dependent Lyapunov function is designed and we propose a method to eliminate the dependence of LPV controller on the derivative of scheduling parameter. The flight envelope of turbofan engine is divided into multiple sub-regions, and a mixing LPV control method with overlapping regions is proposed, which can guarantee stability and performance across the full envelope. Finally, the simulation results on the nonlinear component level model of a twin-spool turbofan engine verify our method.
Endothelial cell‐derived oxysterol ablation attenuates experimental autoimmune encephalomyelitis
Authors: Ruiz Florian , Peter Benjamin , Rebeaud Jessica , Vigne Solenne , Bressoud Valentine , Roumain Martin , Wyss Tania , Yersin Yannick , Wagner Ingrid , Kreutzfeldt Mario , Pimentel Mendes Marisa , Kowalski Camille , Boivin Gael , Roth Leonard , Schwaninger Markus , Merkler Doron , Muccioli Giulio G , Hugues Stephanie , Petrova Tatiana V , Pot Caroline 
Published: January 2023

AbstractThe vasculature is a key regulator of leukocyte trafficking into the central nervous system (CNS) during inflammatory diseases including multiple sclerosis (MS). However, the impact of endothelial‐derived factors on CNS immune responses remains unknown. Bioactive lipids, in particular oxysterols downstream of Cholesterol‐25‐hydroxylase (Ch25h), promote neuroinflammation but their functions in the CNS are not well‐understood. Using floxed‐reporter Ch25h knock‐in mice, we trace Ch25h expression to CNS endothelial cells (ECs) and myeloid cells and demonstrate that Ch25h ablation specifically from ECs attenuates experimental autoimmune encephalomyelitis (EAE). Mechanistically, inflamed Ch25h‐deficient CNS ECs display altered lipid metabolism favoring polymorphonuclear myeloid‐derived suppressor cell (PMN‐MDSC) expansion, which suppresses encephalitogenic T lymphocyte proliferation. Additionally, endothelial Ch25h‐deficiency combined with immature neutrophil mobilization into the blood circulation nearly completely protects mice from EAE. Our findings reveal a central role for CNS endothelial Ch25h in promoting neuroinflammation by inhibiting the expansion of immunosuppressive myeloid cell populations.
Long-term outcome of thyroid abnormalities in patients with severe Covid-19
Authors: Muller Ilaria , Daturi Anita , Varallo Matteo , Re Tiziana E , Dazzi Davide , Maioli Sara , Crivicich Erica , Di Marco Francesco , Longari Virgilio , Dazzi Beatrice , Castellani Massimo , Mantovani Giovanna , Arosio Maura , Salvi Mario 
Published: January 2023

Objective
We have previously observed thyroid dysfunction, i.e. atypical thyroiditis (painless thyrotoxicosis associated with non-thyroidal illness syndrome), in patients with severe acute respiratory syndrome coronavirus 2 disease (Covid-19). This study aimed to analyse the evolution of thyroid dysfunction over time.

Methods
One hundred eighty-three consecutive patients hospitalised for severe Covid-19 without known thyroid history were studied at hospital admission (baseline). Survivors were offered 12-month longitudinal follow-up including assessment of thyroid function, autoantibodies and ultrasound scan (US). Patients showing US focal hypoechoic areas suggestive of thyroiditis (focal hypoechogenicity) also underwent thyroid 99mTc or 123I uptake scan.

Results
At baseline, after excluding from TSH analysis, 63 out of 183 (34%) Covid-19 patients commenced on steroids before hospitalisation, and 12 (10%) showed atypical thyroiditis. Follow-up of 75 patients showed normalisation of thyroid function and inflammatory markers and no increased prevalence of detectable thyroid autoantibodies. Baseline US (available in 65 patients) showed focal hypoechogenicity in 28% of patients, of whom 82% had reduced thyroid 99mTc/123I uptake. The presence of focal hypoechogenicity was associated with baseline low TSH (P = 0.034), high free-thyroxine (FT4) (P = 0.018) and high interleukin-6 (IL6) (P = 0.016). Focal hypoechogenicity persisted after 6 and 12 months in 87% and 50% patients, respectively, but reduced in size. After 9 months, thyroid 99mTc/123I uptake partially recovered from baseline (+28%) but was still reduced in 67% patients.

Conclusions
Severe Covid-19 induces mild transient thyroid dysfunction correlating with disease severity. Focal hypoechogenicity, associated with baseline high FT4, IL6 and low TSH, does not seem to be related to thyroid autoimmunity and may persist after 1 year although decreasing in size. Long-term consequences seem unlikely.
After “The Talk”: Adolescents’ Perspectives Reveal Need for Improvement in Hospital Sexual Health Care Delivery
Authors: Mehta Sonia , Porada Kelsey , Liegl Melodee , Pan Amy , McFadden Vanessa 
Published: January 2023

OBJECTIVES
To fill access gaps for adolescents, addressing sexual and reproductive health (SRH) is recommended in nontraditional settings. In previous improvement work, we increased documentation of sexual history to &gt;80% of adolescents hospitalized on our pediatric hospital medicine (PHM) service. This study assessed adolescents’ perception of SRH conversations with hospital providers and the extent to which they were helpful.

METHODS
Postdischarge survey of patients 13 to 17 years discharged from the PHM service at an academic children’s hospital between August 2019 and March 2020. Survey items included demographics; whether confidential discussion of sexual health topics such as contraception, sexually transmitted infection (STI), and sexual orientation occurred; perceptions of these discussions, and sexual history.

RESULTS
Eighty-three patients enrolled and 44 (53%) completed the survey after discharge. A total of 68% of respondents were female and median age was 15 years (interquartile range 14–16). A total of 77% reported discussing SRH privately with a PHM provider. A total of 18% recalled discussing condoms, and 63% rated the discussion helpful. A total of 27% of females reported discussing birth control, and 40% rated it helpful. A total of 57% recalled discussing sexual orientation, and 40% rated it helpful. None reported discussions of STI testing with PHM. Of the 23% who were sexually active, none reported being given condoms.

CONCLUSIONS
Analysis of adolescent patient experiences identified opportunities for continued improvement in the content and quality of SRH discussions, specifically regarding offering STI testing, condom distribution, and sexual orientation conversations. Our work highlights the importance of incorporating patient-reported data into improvement work to ensure providers are addressing targeted gaps in adolescent care.
Eco-friendly based stability-indicating HPTLC technique for the determination of Escitalopram and Etizolam by employing quality by design approach
Authors: Perumal Durgadevi , Krishnan Manikandan , Lakshmi K.S. 
Published: January 2023

AbstractThe two chemical components Escitalopram (ESC) and Etizolam (ETZ) are beneficial for the health of individuals because it helps to treat anxiety. The study mainly illustrated that a green approach is essential in the medical sector with the help of “Green Analytical quality by design”. According to AQbD, the techniques of HPTLC have become eco-friendly, and decided to use “ESC” and “ETZ”. Hence, ethanol and phosphate buffer pH 3.5 adjusted with 1% “orthophosphoric acid”. After the retardation factor, the product ESC was found at 0.34 min and ETZ was found at 0.53 min. The linearity of ETZ the range varies from 300 to 1800 μg mL−1 and for ESC it varies from 100 to 600 μg mL−1. The validation parameter of R2 Values ranged from 0.9997 to 0.9994 for both ESC and ETZ. The study also demonstrated that different other methods were also useful for the medical sector to make it more convenient and eco-friendly. Some of those approaches are “GAPI”, “AGMS”, “NEMI”, and “AGREE”. The outcome of the study helped to find that the technique “HPTLC” is a green analytic design that helps to maintain the stability of the medicine and it was also approved as a quality design and also a novel approach in the pharmaceutical sector.
Care Perceptions in two ICU Nursing Care Delivery Models: A qualitative-comparative approach
Authors: López Cárdenas William Iván , Henao Murillo Natalia Andrea , Gil Vidal Esteban , Altamirano Ceron Rosa Milena , Santa Mejía Yuly Andrea , Jurado Jiménez Adriana Cristina 
Published: January 2023

Objective. Analyzed in compared perspective perceptions about nursing care, nurse-patient interaction, and nursing care outcomes in two ICU nursing staff in a high-complexity hospital institution, whose Nursing are Delivery Models (NCDM) are differentiated by the proportion of nurses and nurse assistants (NA) per team and by the assigned tasks and responsibilities.
Methods. Particularist ethnography with adaptation to virtual methodologies. It included the sociodemographic characteristics of 19 nurses and 23 NA, 14 semi-structured interviews, review of patients’ clinical records, and a focus group. Coding, categorization, inductive analysis, validation of results with participants were conducted and thematic saturation was achieved.
Results. Four themes were identified: i) Professionalized care: a nursing of superior value; ii) senses and feelings of care; iii) nursing workload, generating factors and impacts; and iv) nursing missed care as concrete expression of the nursing workload.
Conclusion. Compared nursing teams perceived nursing care in different ways, since it was experienced based on the assigned responsibilities and the possibilities of interaction with patients. Nursing care in the NCDM of the ICU with prevalence of direct bedside care by nurses with support from NA, it was perceived as holistic, comprehensive, and empathetic; whereas in the ICU with prevalence of delegated care to NA, it was related with administrative leadership and management of the ICU. Regarding the results, the NCDM of the ICU of direct bedside care by nurses showed better performance in patient safety and was closer to the skill level and legal responsibility of the nursing staff.
XV REUNIÓN DE LA COMISIÓN PERMANENTE DE LA CONFERENCIA IBERO-AMERICANA DE FACULTADES DE FARMACIA (COIFFA)
Authors: AQUIFAR Colegio Nacional de QF COL. Regional Antioquia 
Published: January 2023

PRIMER SIMPOSIO INTERNACIONAL DE CIENCIAS FARMACÉUTICAS Y ALIMENTARIAS: “Identificando propuestas para la solución de problemas prioritarios de los sectores farmacéutico y alimentario”.

PRESENTACIÓN

En la ciudad de Medellín - Colombia, en el marco de la celebración de la XV Reunión de la Comisión Permanente Conferencia Ibero-americana de Facultades de Farmacia (COIFFA), a realizarse el 26 de septiembre de 2012 y a la cual asistirán un número importante de Decanos de las Facultades de Farmacia de Ibero-América, la Facultad de Química Farmacéutica de la Universidad de Antioquia y el Colegio Nacional de Químicos Farmacéuticos de Colombia, regional Antioquia (AQUIFAR) nos hemos comprometido con la realización del Primer Simposio Internacional de Ciencias Farmacéuticas y Alimentarias: “Identificando propuestas para la solución de problemas prioritarios de los sectores farmacéutico y alimentario”, evento que se realizará del 27 al 29 de septiembre de 2012.

El Comité Académico ha estructurado un programa que pretende presentar los avances y novedades nacionales e internacionales relacionados con las ciencias farmacéuticas y alimentarias. Para tal fin, como ponentes participarán líderes académicos e investigadores nacionales e internacionales, reconocidos por sus aportes al avance en el estado del arte de las temáticas definidas para cada uno de los sectores. En este sentido, se desarrollarán 4 conferencias plenarias de interés común para los sectores farmacéutico y alimentario, 4 mesas de debate específicas en los ejes temáticos definidos en cada uno de los dos sectores, 1 mesa orientada a la formación farmacéutica y alimentaria, y 11 presentaciones de trabajos de investigación y/o avances. Con ello, el Comité Académico busca favorecer la definición de propuestas para la solución de problemas prioritarios de los sectores farmacéutico y alimentario en Ibero-América, en especial en el contexto latinoamericano.

Sector Farmacéutico
•	Producción, regulación y comercialización de Productos biológicos y biotecnológicos.
•	Investigación y obtención de sustancias de interés farmacéutico.
•	Diseño y desarrollo de medicamentos.
•	Utilización adecuada de medicamentos.
Sector Alimentario
•	Nanotecnología y su aplicación en alimentos.
•	Compuestos bioactivos de interés alimentario.
•	Nuevas Tecnologías en transformación y procesamiento de alimentos.
•	Globalización Alimentaria: Un reto para todos
Sector Farmacéutico - Alimentario: Educación Farmacéutica y Alimentaria.

Pedro Amariles
Doctor en Farmacia (homologado a Doctor en Farmacología en Colombia)
Profesor Universidad de Antioquia. Responsable del Grupo de Investigación Promoción y Prevención Farmacéutica. Universidad de Antioquia, Medellín.
ELABORATION OF A SCALDED SAUSAGE USING COMMON BEAN FLOUR (<I>Phaseolus</I> spp.) AS EXTENDER
Authors: ALBARRACÍN H. William , ACOSTA A. Luisa F. , SÁNCHEZ B. Iván C. 
Published: January 2023

The use of extenders in the meat industry seeks to replace meat protein in general by vegetal protein from leguminous raw materials easily obtainable with the aim to reduce production costs. In this work was used flour from common bean (Phaseolus spp.) variety Sabanero as an extender, at concentrations of 3%, 6% and 9% for the elaboration of Frankfurt type sausages. The results showed that when the extender concentration was increased, the product lightness increased, the red color decreased and that shear force and hardness increased but adhesiveness and elasticity diminished. Sensory analysis showed greater
acceptance by the consumer of the control samples (without extender) followed by the 3% treatment.
Legal Interpretations of Women, Rape & Criminal Law (Amendment) Act, 2013
Authors: Azam Mr. Akhlaqul 
Published: January 2023

“Women have always been subject to various heinous crimes. Women are easy victim of crimes because of their gender. There are various heinous and grave crimes that are solely meted to the women. One of the most heinous and grave crime meted to women which physically and emotionally affects the women is rape. Laws has always changed to ensure the protection of women in every aspect. Rape is an offence which is most traumatic in its nature. Prior to Criminal Law Amendment Act,2013 the definition of rape was confined to penal-vaginal intercourse between a male and a female, but after Criminal Law Amendment Act,2013 the definition of rape in the penal code is now expanded beyond penile vaginal penetration, to include all forms of non-consensual penetrative sexual acts by men on women. Moving away from a patriarchal framing of the offence, the offence responds more accurately to how women experience penetrative sexual assault. The new amendment defines ‘consent’, to mean an unequivocal agreement to engage in a particular sexual act; clarifying further, that the absence of resistance will not imply consent. When a girl becomes the victim of rape she passes through mental, social and physical difficulties. The effects of rape can include both the initial physical trauma as well as deep psychological trauma. In this paper the concept of rape in the context of legal changes is dealt.”
KAHRAMANIN SEMBOLİK SERÜVENİ BAĞLAMINDA BELAGERDAN DESTANI’NDA YER ALAN MEKÂN SEMBOLLERİ
Authors: ÖZDEMİR Serdar Deniz , KUL Şule 
Published: January 2023

Kolektif bilinç dışının ürünü olan destan, arketipsel sembolleri ihtiva eden bir anlatı türüdür. Bu bağlamda Belagerdan Destanı, Türk kültürünün zenginliğini aksettiren önemli bir hazinedir. Özbek kültür dairesinde gelişen Belagerdan Destanı’nda, Köroğlu’nun oğlu Avazhan’ın kendiliğe ulaşma yolculuğu ele alınmıştır. Kendi içsel benine varmak için maceraya atılan kahramanın seyahati, Joseph Campbell tarafından monomitin çekirdeği olarak ifade edilen “ayrılma, erginleşme ve dönüş” aşamaları ile uyumludur.
Destanda kahramanın maceraya çağrılışı, üvey annesi Yunus Peri’nin, Gırat’ı yanına alarak memleketine kaçmasıyla başlar. Hanımının ve atının kendisini terk etmesiyle güçsüz düşen Köroğlu, Tevekkel mağarasında inzivaya çekilir. Avazhan, babasını bu durumdan kurtarmak amacıyla Erem Bağı’na doğru yolculuğa çıkar. Yaya olarak ilerlediği çöl yolculuğundan sonra Bela Dağı’nda ve Kızıl Kule’de olağanüstü varlıklarla mücadele eder. Tünel kazmak suretiyle periler ülkesindeki cam havuza ulaşır ve burada annesiyle karşılaşır. Annesi tarafından zindana kapatılan kahraman, ruhi bir tekâmülün ardından zindandan kurtulur. Erginleşme yolculuğu boyunca Zenger şehrindeki sınavları da başarıyla yerine getiren Avazhan, bireyleşim sürecini tamamlamış şekilde dönüş yoluna ulaşır. Bütün bu aşamalar içerisinde bilinçaltına ait sembolleri yansıtan varoluş mekânlarının anlatıya üstün bir değer kattığı görülür.
Belagerdan Destanı’nda yer alan mekân sembollerinin kahramanın ruh hâli ile imgesel açıdan uyumlu olduğu açıktır. Destanda ayrıca kolektif bilinç dışına ait arketiplerin kahraman, olağanüstü varlıklar ve mekân arasındaki ilişkiye ontolojik anlamda destek verdiği söylenebilir. Bu makalede, Belagerdan Destanı’nda arketipsel güç taşıyan mekân sembolleri, kahramanın serüveni bağlamında incelenmiştir.
EKOELEŞTİRİ ÇERÇEVESİNDEN AHMET MUHİP DIRANAS’IN ESERLERİ
Authors: TURNA Murat 
Published: January 2023

Ekoeleştiri, ana hatlarıyla çevre-insan-edebiyat üçgeninde geliştirilmiş bir edebiyat kuramıdır. İlk olarak tabiat vurgusuyla dikkat çekse de esasen özünde farklı dinamikler yatar. Tüketim, bilinç, adil ve temiz bir hayat gibi kavram ve görüşler ekseninde şekillenen kuram, insanların çevre duyarlılığın artması için edebiyatı mühim bir kaynak ve vasıta olarak değerlendirir.
Tabiatı konu edinen yazı ve şiirleri ile Ahmet Muhip Dıranas, ekoleştiri çerçevesinden ele alınmaya değer, üretken ve bilhassa ormanlarımız konusunda özel bir hassasiyet sergilemiş bir sanatçıdır. Bu doğrultuda, külliyatının ekoeleştiri kuramıyla incelenmesi, Türk edebiyatındaki çevreci etiğin ve literatürün zenginleşmesine katkı sunacaktır.
Yapılan araştırma neticesinde Dıranas’ın şiirlerinde tabiatın çok yüksek temsil değeri olduğu sonucuna varılmıştır. O, tabiatı şiirlerinde sadece tem olarak kullanmaz. İmgelem boyutuyla da tabiattan yararlanır. Türk şiirinde tabiatın son derece yoğun ve işlevsel kullanıldığı bir şiir damarı oluşturmuştur. Düzyazıları ise ekoeleştirinin neredeyse bütün hatlarını yansıtır niteliktedir. Ormanların yitirilişinden sosyal adalete uzanan bir çizgide, ekoleştirinin gündemine aldığı pek çok konuyu işler. Çarpık kentleşme, köy kent arasındaki uçurum, iskân meselesi, toplumun tabiattan mahrumiyeti, çağın birtakım sorunları ele aldığı konulardır. Sanatçının bu yazıları kaleme aldığı yıllarda, yalnız yurtta değil, dünyada da henüz ekoeleştiri kuramının yerleşik bir yapı arz etmediği dikkate alındığında, Dıranas’ın yazdıklarının çevre bilinci, çevre etiği, çevre felsefesi oluşturup geliştirmede önemli bir yer tuttuğu ileri sürülebilir.
ESKİ TÜRKÇEDEKİ {+(X)t} ÇOKLUK EKİNİN KÖKENİNE DAİR
Authors: AKTEKER Osman 
Published: January 2023

Orhon Türkçesinde oglıt, yılpagut, kanat, tarkat, tigit, seŋüt örneklerinde görülen {+(X)t} çokluk biçim biriminin kökenine dair farklı izahlar yapılmıştır. Bu çokluk biçim birimi, Altay dilleri, İran dilleri ve Ural dilleri olmak üzere üç dil ailesinde görülmektedir.
Bu çalışma; Altay, İran ve Ural dillerinde {+(X)t} çokluk biçim birimini incelemiş ve bu ekin kökenine dair bir varsayım geliştirmiştir. Bu varsayım, Kanonik Yaklaşım ve karşılaştırmalı dil biliminin metotları ile geliştirilmiştir. Kanonik Yaklaşım, morfolojide önemli bir yer tutan çekim sınıflarına dair standart ilkeler belirlemek için geliştirilmiştir. Kanonik Yaklaşım’ın metotları, {+(X)t} çokluk biçim biriminin kökenine dair önemli veriler sunmaktadır. Böylece Kanonik Yaklaşım’ın verileri, karşılaştırmalı dil bilimin verileri ile kıyaslanarak Eski Türkçedeki {+(X)t} çokluk biçim biriminin kökeni izah edilmiştir.
Indonesian Madrasah Competency Assessment: Students’ numeracy based on age
Authors: Kusaeri Kusaeri , Dwisanti Calista , Yanti Aning , Ridho Ali 
Published: January 2023

[English]: This study aims to analyze primary madrasah students’ numeracy based on their age difference; 10-12 years old and to confirm whether the older the students, the better their academic ability when compared to younger students as prior studies suggest. This study used the results of the year 2022 Indonesian Madrasah Competence Assessment (AKMI) in East Java comprising 7.356 students. Students’ numeracy was categorized into five proficiency levels: need intervention, basic, proficient, skilled, and need creative space. Data shows that students who participated in AKMI were dominated by 11-year-old students. In each age group, the spread of the proficiency level is similar, for example, the largest number of students in each group is at the proficient level. Moreover, students in the 11-year-old group have the highest average score, but the difference between the group is not significant. This indicates that they have slightly better numeracy skills than the other groups. Despite the slight difference, the distinct characteristics of each age group could be identified, for example, the number of students, proficiency levels, and average numeracy scores.
[Bahasa]: Penelitian ini bertujuan menganalisis numerasi siswa Madrasah Ibtidaiyah (MI) berdasarkan perbedaan umur; 10-12 tahun dan mengonfirmasi apakah siswa yang lebih tua memiliki kemampuan akademik yang lebih baik daripada siswa yang lebih muda sebagaimana ditunjukkan oleh penelitian terdahulu. Penelitian ini menggunakan data hasil Asesmen Kompetensi Madrasah Indonesia (AKMI) di Jawa Timur yang melibatkan 7.356 siswa. Numerasi siswa dikelompokkan dalam lima kategori kemahiran, yaitu perlu intervensi, dasar, cakap, terampil, dan perlu ruang kreasi. Data menunjukkan bahwa peserta AKMI terbanyak adalah siswa usia 11 tahun. Pada setiap kelompok umur, sebaran level kemahiran tidak berbeda, misalnya, sebagian besar siswa pada setiap kelompok umur berada pada level cakap. Selain itu, siswa pada kelompok umur 11 tahun memiliki rata-rata nilai numerasi tertinggi, namun perbedaan setiap kelompok tidak signifikan. Hal ini menunjukkan bahwa siswa usia 11 tahun memiliki numerasi yang sedikit lebih baik. Walaupun memiliki perbedaan yang tidak signifikan, perbedaan karakteristik setiap kelompok umur tetap dapat diidentifikasi, misalnya jumlah siswa pada tiap kategori usia, tingkat kemahiran, dan rata-rata skor numerasi.