bluuebunny/crossref_metadata_2025_split huggingface dataset:
Role of patient selection and trial stimulation for spinal cord stimulation therapy for chronic non-cancer pain: a comprehensive narrative review
Authors: Shanthanna Harsha , Eldabe Sam , Provenzano David Anthony , Chang Yaping , Adams Daniel , Kashir Imad , Goel Akash , Tian Chenchen , Couban Rachel J , Levit Tal , Hagedorn Jonathan M , Narouze Samer 
Published: March 2023

Background/importancePatient selection for spinal cord stimulation (SCS) therapy is crucial and is traditionally performed with clinical selection followed by a screening trial. The factors influencing patient selection and the importance of trialing have not been systematically evaluated.ObjectiveWe report a narrative review conducted to synthesize evidence regarding patient selection and the role of SCS trials.Evidence reviewMedline, EMBASE and Cochrane databases were searched for reports (any design) of SCS in adult patients, from their inception until March 30, 2022. Study selection and data extraction were carried out using DistillerSR. Data were organized into tables and narrative summaries, categorized by study design. Importance of patient variables and trialing was considered by looking at their influence on the long-term therapy success.FindingsAmong 7321 citations, 201 reports consisting of 60 systematic reviews, 36 randomized controlled trials (RCTs), 41 observational studies (OSs), 51 registry-based reports, and 13 case reports on complications during trialing were included. Based on RCTs and OSs, the median trial success rate was 72% and 82%, and therapy success was 65% and 61% at 12 months, respectively. Although several psychological and non-psychological determinants have been investigated, studies do not report a consistent approach to patient selection. Among psychological factors, untreated depression was associated with poor long-term outcomes, but the effect of others was inconsistent. Most RCTs except for chronic angina involved trialing and only one RCT compared patient selection with or without trial. The median (range) trial duration was 10 (0–30) and 7 (0–56) days among RCTs and OSs, respectively.ConclusionsDue to lack of a consistent approach to identify responders for SCS therapy, trialing complements patient selection to exclude patients who do not find the therapy helpful and/or intolerant of the SCS system. However, more rigorous and large studies are necessary to better evaluate its role.
Review Paper on Beach Evolution of the Indian Coasts
Authors: Mohanty Shravani , Kumar Rajendra 
Published: March 2023

Beaches provide protection to residents living near the ocean by acting as a buffer against the high winds and waves of powerful storms or rough seas. It also helps the government to increase revenue and the development of infrastructure. Because beaches are very accessible to humans, it is very important to go through the demerits that are causing changes in the beaches and what steps can be taken to prevent the beaches from evolving. There are several studies indicating that there is an increase in the wave heights and wave periods along the Indian coasts, with maximum wave heights increasing by more than 30% in some of the locations. It is also found that at most of the locations along the east coast, wave periods are expected to increase by almost 20% whereas along the west coast, they are expected to increase by around 10% [ Chowdhury et al. [ 2019 ] “Wave climate projections along the Indian coast,” Int. J. Climatol. https://doi.org/10.1002/joc.6096 .]. This will alter the distribution of wave energy at the shoreline, swash-aligned beaches and additionally the design of coastal structures. It is particularly important to evaluate the wave characteristics and sediment transport which leads to erosion and/or siltation problems along the Indian coasts. In this paper, an extensive review on wave hydrodynamics, sediment transport and coastal erosion is compiled along the Indian coasts.
Supplementary Method, Supplementary Tables, and Supplementary Figures from Photodynamic Therapy Synergizes with Irinotecan to Overcome Compensatory Mechanisms and Improve Treatment Outcomes in Pancreatic Cancer
Authors: Huang Huang-Chiao , Mallidi Srivalleesha , Liu Joyce , Chiang Chun-Te , Mai Zhiming , Goldschmidt Ruth , Ebrahim-Zadeh Neema , Rizvi Imran , Hasan Tayyaba 
Published: March 2023

<p>(i) Supplementary Methods 1.	Synthesis of L-BPD and L-IRI via freeze-thaw extrusion method 2.	Pharmacokinetics and biodistribution of L-BPD and L-IRI 3.	In-vitro quantification of changes in ABCG2 expression using immunofluorescence 4.	Ultrasound Imaging 5.	Histology and immunofluorescence of tumor samples 6.	Quantification of H&E and immunofluorescence biomarkers 7.	Determination of Synergism (ii) Supplementary Tables Supplementary Table S1. Comparison of PDT and irinotecan doses used in this study versus in clinic Supplementary Table S2. List of antibodies used for immunofluorescence Supplementary Table S3. The synergistic effect of combination PDT and L-IRI Supplementary Table S4. Physical parameters of L-BPD and L-IRI (iii) Supplementary Figures and Legends Supplementary Fig. S1. Treatment schedule and longitudinal monitoring of PanCa tumors in vivo Supplementary Fig. S2. Sub-cytotoxic PDT leads to decreased levels of ABCG2 and increased intracellular irinotecan in AsPC-1 cells Supplementary Fig. S3. Tumor growth kinetics of MIA PACa-2 and AsPC-1 in vivo Supplementary Fig. S4. Change in mouse body weight after combination treatment</p>
Supplementary MovieS2b from Immunotherapeutic Targeting and PET Imaging of DLL3 in Small-Cell Neuroendocrine Prostate Cancer
Authors: Chou Jonathan , Egusa Emily A. , Wang Sinan , Badura Michelle L. , Lee Fei , Bidkar Anil P. , Zhu Jun , Shenoy Tanushree , Trepka Kai , Robinson Troy M. , Steri Veronica , Huang Jiaoti , Wang Yuzhuo , Small Eric J. , Chan Emily , Stohr Bradley A. , Ashworth Alan , Delafontaine Brant , Rottey Sylvie , Cooke Keegan S. , Hashemi Sadraei Nooshin , Yu Brian , Salvati Mark , Bailis Julie M. , Feng Felix Y. , Flavell Robert R. , Aggarwal Rahul 
Published: March 2023

<p>Supplemental Movies 2a-2c: 22Rv1-NuclightGreen and SHP-77-NuclightRed mixed population co-cultures. Time-lapse movies of 22Rv1 cells (labeled with NuclightGreen) and SHP-77 cells (labeled with NuclightRed) co-cultured with T cells. Both the 22Rv1 and SHP-77 cells were plated at equal densities and treated with either NT control BiTE®, AMG 757, or the PSMA-targeting HLE BiTE, AMG 160. T cells were added to each well at an E:T ratio of 10:1. Images were captured every 4 hours at 4x magnification for 5 days.
a.	22Rv1, SHP-77, and T cells co-cultured with NT control BiTE®.
b.	22Rv1, SHP-77, and T cells co-cultured with AMG 757.
c.	22Rv1, SHP-77, and T cells co-cultured with AMG 160.</p>
Supplementary MovieS1d from Immunotherapeutic Targeting and PET Imaging of DLL3 in Small-Cell Neuroendocrine Prostate Cancer
Authors: Chou Jonathan , Egusa Emily A. , Wang Sinan , Badura Michelle L. , Lee Fei , Bidkar Anil P. , Zhu Jun , Shenoy Tanushree , Trepka Kai , Robinson Troy M. , Steri Veronica , Huang Jiaoti , Wang Yuzhuo , Small Eric J. , Chan Emily , Stohr Bradley A. , Ashworth Alan , Delafontaine Brant , Rottey Sylvie , Cooke Keegan S. , Hashemi Sadraei Nooshin , Yu Brian , Salvati Mark , Bailis Julie M. , Feng Felix Y. , Flavell Robert R. , Aggarwal Rahul 
Published: March 2023

<p>Supplemental Movies 1a-1d: 22Rv1-LacZ and 22Rv1-DLL3 cells co-cultures. Time-lapse movies of 22Rv1-LacZ and 22Rv1-DLL3 cells (labeled with NuclightRed) co-cultured with T cells and either NT control BiTE® or AMG 757. T cells were plated at an E:T ratio of 5:1. Images were captured every 6 hours at 10x magnification.
a.	22Rv1-LacZ cells and T cells treated with NT control BiTE®.
b.	22Rv1-DLL3 cells and T cells treated with NT control BiTE®.
c.	22Rv1-LacZ cells and T cells treated with AMG 757.
d.	22Rv1-DLL3 cells and T cells treated with AMG 757.</p>
Supplementary MovieS1c from Immunotherapeutic Targeting and PET Imaging of DLL3 in Small-Cell Neuroendocrine Prostate Cancer
Authors: Chou Jonathan , Egusa Emily A. , Wang Sinan , Badura Michelle L. , Lee Fei , Bidkar Anil P. , Zhu Jun , Shenoy Tanushree , Trepka Kai , Robinson Troy M. , Steri Veronica , Huang Jiaoti , Wang Yuzhuo , Small Eric J. , Chan Emily , Stohr Bradley A. , Ashworth Alan , Delafontaine Brant , Rottey Sylvie , Cooke Keegan S. , Hashemi Sadraei Nooshin , Yu Brian , Salvati Mark , Bailis Julie M. , Feng Felix Y. , Flavell Robert R. , Aggarwal Rahul 
Published: March 2023

<p>Supplemental Movies 1a-1d: 22Rv1-LacZ and 22Rv1-DLL3 cells co-cultures. Time-lapse movies of 22Rv1-LacZ and 22Rv1-DLL3 cells (labeled with NuclightRed) co-cultured with T cells and either NT control BiTE® or AMG 757. T cells were plated at an E:T ratio of 5:1. Images were captured every 6 hours at 10x magnification.
a.	22Rv1-LacZ cells and T cells treated with NT control BiTE®.
b.	22Rv1-DLL3 cells and T cells treated with NT control BiTE®.
c.	22Rv1-LacZ cells and T cells treated with AMG 757.
d.	22Rv1-DLL3 cells and T cells treated with AMG 757.</p>
Mecanismos de ocorrência de dor
Authors: Teixeira Manoel Jacobsen 
Published: March 2023

Vários mecanismos estão envolvidos na ativação e supressão das unidades nociceptivas. Traumatismos físicos e químicos ambientais ativam e sensibilizam os nociceptores nos tecidos. Disto resulta liberação tecidual de neurotransmissores excitatórios que sensibilizam e ativam as vias nociceptivas no sistema nervoso periférico e central. No sistema nervoso central das unidades envolvidas nos mecanismos sensitivo-discriminativos, afetivomotivacionais e quantitativo-avaliativos da sensibilidade. Nas unidades nervosas periféricas, nos gânglios sensitivos e nas unidades neuronais da medula espinal e encefálica há mecanismos supressores de dor; são ativados pela liberação de neurotransmissores inibitóriosquando da apresentação de estímulos discriminativos. Do desbalanço da atividade das vias excitatórias e da vias supressoras ocorre a dor.
Observations of a Filamentous Intrusion and Vigorous Submesoscale Turbulence within a Cyclonic Mesoscale Eddy
Authors: Hu Zhendong , Lin Hongyang , Liu Zhiyu , Cao Zhiyong , Zhang Fangtao , Jiang Zongpei , Zhang Yao , Zhou Kuanbo , Dai Minhan 
Published: March 2023

Abstract
Oceanic submesoscale flows are considered to be a crucial conduit for the downscale transfer of oceanic mesoscale kinetic energy and upper-ocean material exchange, both laterally and vertically, but defining observations revealing submesoscale dynamics and/or transport properties remain sparse. Here, we report on an elaborate observation of a warm and fresh filament intruding into a cyclonic mesoscale eddy. By integrating cruise measurements, satellite observations, particle-tracking simulations, and the trajectory of a surface drifter, we show that the filament originated from an anticyclonic eddy immediately to the west of the cyclonic eddy, and the evolution of the filament was mainly due to the geostrophic flows associated with the eddy pair. Our observations reveal the mass exchange of the eddy pair and suggest that submesoscale flows can degrade the coherence of mesoscale eddies, providing important implications for the transport properties of mesoscale eddies. Vigorous submesoscale turbulence was found within the eddy core region, due to filamentous intrusion and frontogenesis. Our findings have thus offered novel insights into the dynamics and transport properties of oceanic submesoscale flows, which should be taken into account in their simulation and parameterization in ocean and climate models.

Significance Statement
Mesoscale eddies, with a spatial scale from tens to hundreds of kilometers, are ubiquitous in the global ocean. Carrying the largest proportion of oceanic kinetic energy, mesoscale eddies play a key role in ocean dynamics and have important applications for marine biology. Although mesoscale eddies have been studied extensively over the past decades, there are two major issues that remain inconclusive: (i) How do mesoscale eddies dissipate? (ii) Can eddies coherently trap waters when moving over a long distance? Recent studies, mostly through computer simulations, suggest that oceanic submesoscale processes, with a typical scale of a few kilometers, are highly relevant to the above two issues. This study presents a rare observation of a filament intruding into a cyclonic eddy. Because of this filament intrusion, submesoscale activities are enhanced near the eddy core area, in contrast to previous observations that normally suggest weaker submesoscale activities in the eddy core area than at eddy peripheries. Such dedicated process-oriented observations provide unique opportunities for better understanding the dynamics and transport properties of mesoscale eddies and submesoscale processes.
Experiences of older people, healthcare providers and caregivers on implementing person-centered care for community-dwelling older people: a systematic review and qualitative meta-synthesis
Authors: Liao Lulu , Feng Mingjiao , You Yanjie , Chen Yuqin , Guan Chunyan , Liu Yilan 
Published: March 2023

Abstract
Background
Person-centered care (PCC) is a critical approach to improving the quality of care for community-dwelling older people. Old-age care services could be provided according to older peoples’ choices, needs, and preferences. The purpose of this study was to synthesize research evidence on the experiences of older people, healthcare providers, and caregivers with PCC and to identify the enablers and barriers to implementing PCC for community-dwelling older people.

Methods
A meta-synthesis of qualitative research design was adopted. Data searches were performed using CINAHL (EBSCOhost), PubMed (OvidSP), Embase (Ovid), Cochrane Database, and PsycINFO (Ovid) in published articles and were reviewed from the earliest date to February 2023. The Qualitative Method Appraisal Tool was used to conduct a quality appraisal on selected articles. Data were extracted based on the capacity, opportunity, and motivation-behavior model (COM-B model), and the findings were synthesized using the meta-aggregative approach.

Results
Twelve included articles were analyzed to identify 122 findings that were organized into 11 categories and combined into three synthesized findings—capacities of older people, healthcare providers, and caregivers; opportunities in the implementation of PCC; motivation in implementing PCC. Capacities consisted of a lack of person-centered knowledge and skills, negative attitudes toward shared decision-making, and a lack of formal training to enhance capabilities among HCPs. Opportunities included a lack of coordination in resource allocation, strengthening multidisciplinary teamwork, establishing a desirable environment, and time constraints. Motivation in implementing PCC included encouraging self-reflection and regulation, respecting the autonomy of older people, lack of clear reward and empowerment mechanisms, and being resilient and optimistic.

Conclusions
The findings of this research provide a reference for implementing successful PCC in the community. The researchers identified barriers and facilitators of implementing PCC, facilitating through stakeholder’s person-centered knowledge and skills being valued and respecting the autonomy of older people. Establishing a positive environment and strengthening multidisciplinary team members also promotes the implementation of PCC. However, additional studies are required to explore the influencing factors and address the barriers.
The value of lung ultrasound in COVID-19 pneumonia, verified by high resolution computed tomography assessed by artificial intelligence
Authors: Chrzan Robert , Polok Kamil , Antczak Jakub , Siwiec-Koźlik Andżelika , Jagiełło Wojciech , Popiela Tadeusz 
Published: March 2023

Abstract
Background
Lung ultrasound (LUS) is an increasingly popular imaging method in clinical practice. It became particularly important during the COVID-19 pandemic due to its mobility and ease of use compared to high-resolution computed tomography (HRCT). The objective of this study was to assess the value of LUS in quantifying the degree of lung involvement and in discrimination of lesion types in the course of COVID-19 pneumonia as compared to HRCT analyzed by the artificial intelligence (AI).

Methods
This was a prospective observational study including adult patients hospitalized due to COVID-19 in whom initial HRCT and LUS were performed with an interval < 72 h. HRCT assessment was performed automatically by AI. We evaluated the correlations between the inflammation volume assessed both in LUS and HRCT, between LUS results and the HRCT structure of inflammation, and between LUS and the laboratory markers of inflammation. Additionally we compared the LUS results in subgroups depending on the respiratory failure throughout the hospitalization.

Results
Study group comprised 65 patients, median 63 years old. For both lungs, the median LUS score was 19 (IQR—interquartile range 11–24) and the median CT score was 22 (IQR 16–26). Strong correlations were found between LUS and CT scores (for both lungs r = 0.75), and between LUS score and percentage inflammation volume (PIV) (r = 0.69). The correlations remained significant, if weakened, for individual lung lobes. The correlations between LUS score and the value of the percentage consolidation volume (PCV) divided by percentage ground glass volume (PGV), were weak or not significant. We found significant correlation between LUS score and C-reactive protein (r = 0.55), and between LUS score and interleukin 6 (r = 0.39). LUS score was significantly higher in subgroups with more severe respiratory failure.

Conclusions
LUS can be regarded as an accurate method to evaluate the extent of COVID-19 pneumonia and as a promising tool to estimate its clinical severity. Evaluation of LUS in the assessment of the structure of inflammation, requires further studies in the course of the disease.

Trial registration
The study has been preregistered 13 Aug 2020 on clinicaltrials.gov with the number NCT04513210.
Severity as a moral qualifier of malady
Authors: Solberg Carl Tollef , Barra Mathias , Sandman Lars , Hoffmann Bjørn 
Published: March 2023

AbstractThe overarching aim of this article is to scrutinize how severity can work as a qualifier for the moral impetus of malady. While there is agreement that malady is of negative value, there is disagreement about precisely how this is so. Nevertheless, alleviating disease, injury, and associated suffering is almost universally considered good. Furthermore, the strength of a diseased person’s moral claims for our attention and efforts will inevitably vary. This article starts by reflecting on what kind of moral impetus malady incites. We then analyze how severity may qualify this impetus. We do so by discussing the relationship between severity and need, well-being and disvalue, death, urgency, rule of rescue, and distributive justice. We then summarize our thoughts about severity as a moral qualifier. We conclude that severity is, and should continue to be seen, as a morally significant concept that deserves continued attention in the future.
Hacia la comprensión de la cultura organizacional colombiana. Un enfoque desde los valores en competencia
Authors: Calderón-Hernández Gregorio , Vivares Jorge A. , Jiménez-Munive José María 
Published: March 2023

La cultura organizacional se ha posicionado como un asunto estratégico por su potencial para el desarrollo de las empresas, su estudio en países emergentes como Colombia ha cobrado relevancia, pero son insuficientes las investigaciones científicas sobre el particular. El propósito de este artículo es responder ¿cómo y de qué tipo es la cultura organizacional de nuestras empresas? Metodológicamente se realizó un estudio empírico desde el paradigma lógico-positivista a fin de conocer las percepciones de la gente acerca de la realidad estudiada, mediante la aplicación de encuestas en 465 empresas colombianas ubicadas en 29 departamentos, para lo cual se hizo una adecuación del instrumento OCAI (Organizational Culture Assessment Instrument), basado en el enfoque de valores en competencia. Las medidas de validez y confiabilidad soportaron la consistencia de los constructos utilizados y su fiabilidad. Se encontró que el tipo de cultura jerárquica es la dominante en las empresas colombianas, aunque se identificó la presencia de otras culturas, como la clan, la adhocrática y la de mercado, al clasificarlas por tamaño, sector y tipo de organización. La novedad del estudio está en la comparación de culturas clasificándolas por tamaño, sector económico y tipo de empresa (familiares versus no familiares),además de brindar hallazgos útiles para comprender mejor el tejido empresarial colombiano, con el potencial para enriquecer las estrategias de fortalecimiento.
Near-perfect wide-band absorbers based on one-dimensional photonic crystal structures in 1–20  THz frequencies
Authors: Mokhtari Abolfazl , Rezaei Mir Hamid , Zarifkar Abbas 
Published: March 2023

This paper investigates the absorption behavior of one-dimensional (1D) photonic crystal (PhC) structures in the 1–20 THz region. The structures are analyzed by the transfer matrix method to achieve accurate results quickly with ordinary simulation facilities. The simulation results indicate a strong dependence of the absorber performance on the thickness and material of the PhC layers, as well as the frequency and angle of incident light. The combination of silica and titanium (Ti) materials as dielectric and metal layers presents a great choice for broadband high-absorption applications so that this structure can absorb, on average, more than 80% of the normal incident radiation in the studied frequency range. Additionally, this absorber has the lowest dependence on incident light with the angle varying from 0° to 80° compared to identical absorbers with silver, aluminum, gold, chromium, nickel, and tungsten metals. The excellent absorption feature of the Ti-based absorber compared to the other absorbers is attributed to the lower permittivity of Ti (in both real and imaginary parts) in comparison with the other metals. In addition to owning simple and fabrication-friendly structures, 1D PhCs can pave the way to achieve various absorption spectra proportional to the needs of photonics, communications, and aerospace applications.