bluuebunny/crossref_metadata_2025_split huggingface dataset:
Return Saham di Tinjau dari Profitabilitas
Authors: Rosyada Rosyada 
Published: May 2023

ABSTRAK
This study aims to determine the impact of profitability on stock returns in companies listed on the Jakarta Islamic Index 70 proxied by stock returns. The total population of companies listed on the JII during the study period was 70 companies. The sempel retrieval technique in this research is purposive sampling and 17 companies are obtained as sempel for this study. The analysis technique used to analyze the data is multiple linear regression with a significant level of 5% and hypothesis testing using the t test and F test. The results of this study indicate that the ROA variable affects stock returns with a t value of 2.853> t table 2.01410 and a significance value of 0.007 <0.05. The EPS variable has no effect on stock returns with a t value of 0.047 < t table 2.01410 with a significance value of 0.963 > 0.05. Then simultaneously the ROA and EPS variables affect stock returns with a calculated F value of 4.286> Ftable 3.21 and a significance of 0.020 <0.05. The conclusion shows that simultaneously the ROA and EPS variables have an influence on stock returns, while partially only the ROA variable has an influence on stock returns.
Development and Validation of an Inventory to Evaluate Teaching Strategies for Promoting Higher-Order Thinking Skills in the Teaching of Islamic Education
Authors: Ghazali Nor Hasnida Che MD , Rabi Norfishah Mat , Wahab Norwaliza Abdul , Rohaizad Nor Aizal Akmal 
Published: May 2023

The purpose of this study is to develop and assess the validity and reliability of an inventory on teaching strategies involved in promoting HOTs as well as to identify the most and the least popular teaching strategies used. The inventory is adapted from Gulistan et al. (2016). It is in the form of questionnaire distributed to a sample of 220 primary school teachers teaching Islamic education subject. The content validity is assessed by the experts and the construct validity is measured by Exploratory Factor Analysis. The reliability of the instrument is measured using internal consistence reliability, which is alpha coefficient reliability or Cronbach Alpha. Results of exploratory factor analysis suggested that 5 items need to be removed due to their non-dimensionality as they have more or less equal loadings on several factors. The instrument developed yielded high values of internal consistency as reflected by the Cronbach alpha values. Thus, the final draft of the instrument contains 26 items which are valid and reliable. Even though the validity and reliability of the instrument are within the acceptable range, more data need to be gathered using a bigger sample size, and further analysis using confirmatory factor analysis could be used to explore deeper into the psychometric characteristics of the items before the instrument can be finalized. Furthermore, the findings of the study indicated that the most popular strategy used among teachers teaching Islamic education was the strategy for acquiring knowledge which introduces students more on memorizing basic concepts, while the least used strategy was the higher cognitive skills teaching strategies such as problem solving, collaborative learning and inquiry strategies.
Rupture of the Flexor Pollicis Longus Tendon from the Metacarpophalangeal Sesamoid and Joint in a Rheumatoid Patient
Authors: Winek Nathan C. , Wroblewski Andrew , Greco Victor E. , Palmer Bradley 
Published: May 2023

Case:
A 54-year-old woman with rheumatoid arthritis presented with a flexor pollicis longus (FPL) rupture at the level of the metacarpophalangeal joint secondary to attritional damage from metacarpophalangeal (MCP) degenerative changes and exostoses from the radial sesamoid. She underwent direct tendon repair with debridement of the MCP joint and radial sesamoidectomy.

Conclusion:
Rheumatoid arthritis can potentially lead to rupture of the FPL tendon in locations distal to the carpus, namely at the level of the MCP joint. Contrary to other reports, a quality outcome may be obtained with direct repair and may not necessarily require tendon transfer, fusion, or grafting.
A realist evaluation of multifactorial falls risk assessment and prevention practices
Authors: Alvarado Natasha , McVey Lynn , Healey Frances , Dowding Dawn , Zaman Hadar , Cheong V-Lin , Gardner Peter , Lynch Alison , Hardiker Nick , Randell Rebecca 
Published: May 2023

Abstract
Background: Multifactorial falls risk assessments (MFRAs) and personalised interventions are recommended practices to reduce risk of falls in hospitals, but there is variation in implementation at practice level, reasons for which have not been explored. The aim of this study was to explore reasons for the variation.
Methods: Realist evaluation was used to interrogate how, why and in what contexts falls prevention practices are implemented. Four realist hypotheses about delivery of MFRAs and personalised interventions labelled: Falls Leadership, Facilitation via MFRA tools, Shared responsibility, and Patient participation were tested. Testing was conducted via a multi-site case study in three acute hospitals in older person and orthopaedic wards. Data collection included ethnographic observations (251.25 hours); interviews with staff (n=50), patients and carers aged over 65 (n=31); and clinical record review (n=60).
Results: MFRA tools were embedded in nursing practice, located in the Electronic Health Record. Nurses reported that these tools prompted assessment of individual falls risk factors and clinical records indicated that MFRAs and prevention plans were documented with consistency. However, assessment items varied between MFRA tools and competing priorities on nurse time could reduce tool use to a tick-box exercise. Patient supervision, delivered with different levels of intensity by nursing staff, was a key falls prevention intervention. Supervision appeared to constrain the extent to which responsibility for preventing falls was felt to be shared within multidisciplinary teams. Staff interactional skills such as conveying sincerity encouraged patient participation in interventions and understanding patient perspectives enabled personalisation of care in ways that supported their engagement in safety efforts; non-nursing staff and carers helped surface patient perspectives.
Conclusions: Organisational policy reflects the MFRA approach. However, to promote reliable delivery of multidisciplinary, personalised interventions, and to help ease the nursing burden, organisations should consider how systems can support clinical teams to work together cohesively to modify individual falls risk factors, and drawing on non-nursing staff and carers to help personalise care in ways that encourage patient participation and engagement in safety efforts.
Comprehensive, high-precision tree census enhances conservation justification for critically threatened tropical forest fragments
Authors: Webb Edward L. , Lalogafu’afu Avele Iofi , Mekuli Opeta , Olo Eti , Taisegi Lalakai , Taua Nerisa , Tualaulelei Ailao , Vaito'a Jeff , Jamaludin Johannes , Miles Adam C. 
Published: May 2023

Abstract

Small, isolated tropical forest fragments may be suitable targets for conservation intervention. Where significant financial investment is required (e.g. conservation easement, private land acquisition) justification requires evidence of importance, threat, and strategic importance. Comprehensive inventories of biodiversity can enhance this justification. We used historical imagery and a comprehensive high-precision tree census to assess conservation importance, threat and strategy of a 9.33 ha fragment of lowland pahoehoe lava flow forest. Using high-precision total station mapping of all trees (n = 4087), we demonstrate the botanic and wildlife importance of this fragment. We use aerial imagery extending back 70 years to illustrate the continued and increasing threats to this fragment and argue that conservation intervention can mitigate those threats and promote long-term persistence of the forest and its biodiversity. Finally, we illustrate the strategic cultural services of this site, in particular opportunities for public engagement with the forest. Finally, we discuss several key benefits of total station mapping for research, conservation and management of tropical forests.
Systemic Immune-Inflammation Index After Neoadjuvant Therapy Predicts the Pathological Response in Patients with Resected Pancreatic Ductal Adenocarcinoma
Authors: Shen Shuo , Zhu Lingyu , Li Bo , Yin Xiaoyi , Shi Xiaohan , Gao Suizhi , Wang Huan , Zhang Guoxiao , Jing Wei , Zheng Kailian , Li Gang , Guo Shiwei , Jin Gang 
Published: May 2023

Abstract

Background: Pancreatic ductal adenocarcinoma (PDAC) patients have improved prognosis after neoadjuvant therapy (NAT). However, there is a lack of biomarkers to predict the pathological response preoperatively. We evaluated the predictive value of multiple biomarkers, including inflammatory biomarkers, for predicting the pathological responses.
Methods: We respectively reviewed the records of patients with localized PDAC who underwent NAT followed by resection between January 2017 and May 2021 at the First Affiliated Hospital of Naval Medical University. The patients were divided into the major pathological response (MPR) and non-MPR groups, according to the tumor regression grade. Univariate and multivariate predictors of MRP were explored. The predictive factors identified on multivariate analysis were used to establish a nomogram prognostic model, which was evaluated using the Decision Curve Analysis (DCA).
Results: A total of 150 patients, including 21 in the MPR and 129 in the non-MPR group, were analyzed. In the multivariate analysis of the MRP group, normal CA19-9 level (<37U/ml)(odds ratio, OR = 32.014; 95% confidence interval (CI) = 3.809–269.071; p = 0.001), post-NAT SII < 530 (OR = 14.739; 95% CI = 2.811–77.265; p = 0.001), and use of Stereotactic Body Radiation Therapy (OR = 8.370; 95% CI = 2.175–32.205) predicted MPR in PDAC patients. DCA showed that the nomogram prognostic model had a higher predictive value than standard radiological assessments.
Conclusions: In resected PDAC, post-NAT normal CA19-9 level, post-NAT SII, and use of Stereotactic Body Radiation Therapy predicted MPR after NAT in PDAC patients. Post-NAT SII can be used as a biomarker to determine the treatment response.
Association between CXCL5 and the Coronary Artery Disease and identify the effects of CXCL5 on the adhesion and migration of THP-1 to ECs
Authors: Liu Tengfei , Ding Chunhua 
Published: May 2023

Abstract

Aims: Chemokines play important roles in the development and progression of atherosclerosis and coronary artery disease (CAD). The purpose of this study was to identify the relationship between CXCL5 and the risk of CAD and try to reveal the relative mechanisms.
Methods: 395 CAD patientsand 403 controls were enrolled in this study. Using RT-PCR method to detected CXCL5 gene expression and Elisa method to determine CXCL5 plasma levels of were tested by in 160 CAD patients matched well with 160 controls. Established CXCL5over expression, reduction and control EC lines; The chemotactic ability of THP-1 cells to ECs was evaluated by adhesion and transwell assay, and the signaling pathway expression was detected by Western blot.
Results: Our study revealed CXCL5 gene expression and serum levels in CAD group were much higher than those in control group (P < 0.01, respectively). CXCL5 concentrations in CAD group (4.85 ± 0.19ng/mL) were significantly higher than that in control group (3.66 ± 0.14ng/mL) (P < 0.05). Logistic regression analysis indicated CXCL5 was a susceptibility factor of CAD and significantly correlated with CAD (P < 0.05). In adhesion and migration experiments, the numbers of THP-1 cells in CXCL5 overexpression groups (EO) were much higher than CXCL5suppression groups (ES), lenti - MOCK infected groups (MOCK) and non - infected groups (EN) (P value < 0.05, respectively). Nevertheless, numbers of THP-1 cells in ES groups were significantly lower than other groups (P < 0.01, respectively).
Conclusions: The evidence from our study indicated that CXCL5 might be a new biomarker in assessing the risk of CAD. Our study showed that CXCL5overexpression facilitate the adhesion and migration of THP-1 to ECs.
SCR-6852, an oral and highly brain-penetrating estrogen receptor degrader (SERD) effectively shrinks tumors both in intracranial and subcutaneous ER+ breast cancer models
Authors: Zhou Feng , Yang Guimei , Xue Liting , Liu Yajing , Guo Yao , Zhu Ji , Yuan Linlin , Gu Peng , Tang Feng , Shan Jinwen , Tang Renhong 
Published: May 2023

Abstract
Background: Targeted estrogen receptor degradation has been approved to effectively treat ER + breast cancers. Due to the poor bioavailability of fulvestrant, the first generation of SERD, many efforts were made to develop oral SERDs. With the approval of Elacestrant, oral SERDs demonstrated superior efficacy than fulvestrant. However, due to the poor ability of known SERDs to penetrate the blood-brain barrier (BBB), breast cancer patients with brain metastasis cannot benefit from clinical SERDs.Methods The ER inhibitory effects were evaluated on ERα protein degradation, and target genes downregulation. And anti-proliferation activities were further determined in a panel of ER + breast cancer cell lines. The subcutaneous and intracranial ER + tumor models were used to evaluate the efficacy of anti-tumor effects. Brain penetrability was determined in multiple animal species.Results SCR-6852 is a novel SERD and currently is under early clinical evaluation. In vitro, studies demonstrated that it strongly induced both wildtype and mutant ERα degradation. It potently inhibited cell proliferation in a panel of ER + breast cancer cell lines, including the cell lines containing ESR1 mutations (Y537 and D538). Furthermore, SCR-6852 showed completely antagonistic activity on the ERɑ signal axis identified both in vitro and in vivo. Oral administration of SCR-6852 at 10mpk resulted in tumor shrinkage which was superior to Fulvestrant at 250mpk, Notably, in the intracranial tumor model, SCR-6852 effectively inhibited tumor growth and significantly prolonged mice survival, which correlated well with the high exposure in brains. In addition to mice, SCR-6852 also exhibited high brain penetrability in rats and dogs.Conclusions SCR-6852 is a best-in-class SERD with high potency in inducing ERα protein degradation and completely antagonistic activity on ERɑ signaling in vitro and in vivo. Due to the high brain penetrability, SCR-6852 could be used to treat breast patients with brain metastasis.
Extent of interlocking and metallurgical bonding in friction riveting of aluminum alloy to steel
Authors: Srivast Abhinav , Das Hrishikesh , Tamayo Daniel Ramirez , Li Lei , Pole Mayur , Gwalani Bharat , Soulami Ayoub , Santos Jorge F. dos , Kappagantula Keerti S. , Reza-E-Rabby MD 
Published: May 2023

Abstract
In this study, the joining of 6061-T6 aluminum alloy and DP590 steel using a M42 steel rivet via friction riveting technique is investigated. The surface morphology and microstructure characterization reveal the formation of an anchor zone that imparts mechanical interlock as well as the formation of metallurgical bonds at the interface of aluminum and steel. A combination of interlocking and bonding results in the achievement of a high load-carrying capacity of 5.7 kN during lap shear testing at room temperature. A finite element-based computational model was developed which accurately predicted the lap shear response of the joint. The model revealed that the metallurgical bond formed during fric-riveting adds 39% peak load strength to the joint. An extensive microstructural investigation, post-lap-shear fractography, and the modeling results, together provided insights on the joint failure mechanism. This study highlights that friction riveting is a promising method for aluminum-to-steel dissimilar joining, which is important for lighweighing automotive vehicles for energy efficiency.
Fault Estimation for Nonlinear Uncertain Systems with Disturbance Utilizing Neural Network-Based Robust Iterative Learning Scheme
Authors: Chen Zhengquan , Huang Ruirui , Ma Jiulong , Wang Jinjin , Hou Yandong 
Published: May 2023

Abstract
In this paper, a novel neural network-based robust iterative learning fault estimation scheme is proposed to address the problem of fault modeling and estimation in nonlinear manipulator systems with disturbances and parameter uncertainties. The aim is to enhance the rapidity, efficiency, and accuracy of fault estimation. Firstly, the modeling for flexible manipulator control system is constructed as a preparation of iterative learning fault estimation observer design. Then, the neural network model is constructed to optimize the gain parameters of iterative learning fault estimator to approximate nonlinear uncertainties. Additionally, a H∞ robust technique is used to suppress fault variation rate and disturbances, which enhances the speed of estimation and reduces the impact of disturbances. So that the estimated fault can rapidly and accurately track the actual fault over the whole time interval and iterations. Finally, numerical simulations are conducted to demonstrate the effectiveness of the proposed neural network-based robust iterative learning scheme.
Network analysis of quality of life in older breast cancer patients: A cross-sectional research from China
Authors: Xiao Min , Qian Xiaoyan , Chen Xi , Ji Lei , Xiu Meng , Li Zhuoran , Cao Heng , Chen Shanshan , Li Qing , Li Qiao , Wang Xiang , Wang Jiani , Li Yiqun , Xu Binghe , Zhang Pin 
Published: May 2023

Abstract

ObjectiveThe balance between treatment effectiveness and quality of life in elderly breast cancer patients is an important issue for clinicians to consider. The purpose of this study was to investigate the quality of life of elderly breast cancer patients and to explore the most critical factors affecting the quality of life.MethodsThis prospective cross-sectional study was conducted in the Cancer Hospital of the Chinese Academy of Medical Sciences from June 2022 to November 2022. Frailty Screening Scale and the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 were assessed among breast cancer patients aged ≥65 years. Network analysis was used to identify the core symptoms in the network.Results481 patients who met inclusion criteria were included in the final analysis. Patients were divided into early (stage I-III) and advanced (stage IV) stage groups based on AJCC Version 8. Patients with advanced disease had a higher incidence of frailty than those with early disease (29.5% vs 11.4%, P<0.001). The quality of life of the former was generally lower than the latter group (P < 0.05 for all three functional areas, seven single symptoms, and economic aspects). Network analysis showed that in both early and advanced stage patients, "fatigue" was the most important symptom in the network and was closely related to patients' social function, role function and physical function. It is also most directly related to global health/quality of life (gQoL).ConclusionThere is a general decline in quality of life in older women with advanced breast cancer. Fatigue is the most prominent problem that affects the quality of life. Related interventions need to be considered when developing clinical care plans for these patients.
Förster-free effect fluorescence quenching of 5,10,15,20-tetraphenylporphyrin in solution
Authors: Elistratova Marina , Zakharova Irina 
Published: May 2023

Abstract

Inner-filter absorption of the exciting light by the quencher or may be cause of large errors in the evaluation of quenching efficiencies in measurements of fluorescence quenching. We performed fluorescence measurements of 5,10,15,20-tetraphenylporphyrin toluene solution in a wide concentration range. We have shown a Förster-free fluorescence quenching in a right-angle geometry experiment, caused by second order inner filter. We proposed to perform measurements in a front-surface geometry to investigate the nature of quenching not related to the inner filters. We have shown that concentration effects in tetraphenylporphyrin solutions in toluene are not accompanied by a decrease in the fluorescence intensity in a front-surface geometry at concentrations of 10− 3-10− 7 mol/l. It was possible to separate the phenomena of the internal filters from the processes occurring in a liquid medium. Our results are of great importance due to the widespread fundamental research of porphyrin-based dyes properties.
Multi-objective Scientific Workflows Scheduling in An Energy-aware Cloud Environment
Authors: Dahmani Nadia , Aziza Hatem , Romdhane Hajer Ben , Krichen Saoussen 
Published: May 2023

Abstract
The cloud has become an essential element for businesses globally, providing constant data availability while improving data center energy efficiency and reducing carbon footprints. However, data centers' energy consumption remains high, and energy reduction has become a crucial objective. In this paper, we aim to address this concern by proposing a multi-objective scientific workflow scheduling scheme on heterogeneous computing systems using a hybrid genetic algorithm approach. Our algorithm incorporates Hill Climbing to generate an initial population of chromosomes, which we further optimize using a genetic algorithm to assign each task to the most suitable virtual machine. The proposed fitness function is carefully designed to evaluate each chromosome's fitness to solve the scheduling problem. The algorithm's parameters and operators significantly affect the solution's performance, and our results show that the proposed algorithm outperforms other scheduling methods in terms of quality, reducing energy consumption, processing time, and cost. We believe that our proposed approach can play a crucial role in reducing the energy consumption and carbon footprint of cloud data centers and provide a green solution for scientific workflow scheduling.
Investigation on the Electrochemical Activities of Pristine and Cerium doped Manganese Dixide Nanoparticles for Supercapacitor Electrode Materials
Authors: Nandhini K. , devi M. Uma , Jose L. Arun , Kumar P. Mathan , Muthuraaman B. , Jothi M. Anantha 
Published: May 2023

Abstract
The synthesis of pristine Manganese dioxide and Cerium doped Manganese dioxide nanoparticles was reported in this article. X-Ray Diffraction Spectroscopy was examined to find the crystal structure and other structural parameters. The crystallite size of the obtained nanoparticles was found to be in the range of 18-22nm. The functional groups were identified by Fourier Transform Infrared Spectroscopy. Surface morphology and elemental analysis was done by Scanning Electron Microscopy with Energy Dispersive X-ray Spectroscopy. SEM pictures clearly illustrate that the synthesized samples hold porosity nature. Further, Cyclic Voltammetry, Galvanostatic Charge Discharge studies and Electrochemical Impedance Spectroscopy were carried out to test the electrochemical activities of the resulting nanoparticles. This study suggests that the synthesized materials can be used as electrode material in supercapacitor applications.