bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment and valuation of technologies, development and application of Valorativo software
Authors: Freitas Robson Almeida Borges De , Oliveira Junior Antonio Martins de 
Published: March 2023

PurposeAlthough Public Research Institutions (PRIs) are large technology producers, they lack automated information tools that follow technical and scientific criteria for assessing and valuing patents. The assessment and valuation processes are stages of technology transfer (TT) that make it possible to obtain productive arrangements and guide the efforts of those involved in the development, maintenance and negotiation. This study aims to analyze the hybrid model of assessment and valuation of technologies by Soares (2018), applying the ‘Valorativo' software. In addition to patent value and indicator scores, the methods allow an understanding of the technology portfolio and its management.Design/methodology/approachThis research is quali-quantitative, following an approach of applied nature and descriptive objectives. The research has bibliographical, documental and case study features based on the software development methodologies described in the study and the theoretical framework.FindingsThe Valorativo software assisted in the analysis of ten patents on PRIs. With the data collection and patent analysis, PAT1 scored highest among engineering patents, PAT3 scored highest among pharmaceutical patents and PAT10 scored highest among biotechnology patents. Five of the assessed patents resulted in a surplus of net present value (NPV), final net present value (NPVF) and royalties; revenue expectations outpaced investments.Practical implicationsThe authors based the developed software on Soares’s (2018) methodology, with additional calculations and graphs. The Web software and the spreadsheet with Visual Basic for Application (VBA) were developed to deal with the patents assessment and valuation, helping in the analysis of their Legal Value, Technological Value and Market Conditions in the assessment process, and the Discounted Cash Flow and NPV in the valuation process.Originality/valueThe software helps with patent analysis and can generate indicators for traders, technology holders and researchers. Thus, it was necessary to understand and develop a theoretical-applied framework to outline and replicate the methodology clearly and easily.
Embedded agency in competitive environments: distribution of new occupations for data-oriented practices
Authors: Kim Jaemin , Greiner Michael , Miree Cynthia 
Published: March 2023

Purpose
In competitive environments, explicitly seeking institutional changes to adopt a new technology, rather than exploiting current resources, can harm more than help organizations’ efforts to achieve their performance goals. However, institutionally embedded organizations often respond to the introduction of industry disruptive technology in counterproductive ways. This paper aims to study the paradox of embedded agency in competitive environments and explore the diffusion of new occupations associated with data analytics.

Design/methodology/approach
This study uses the context of the Major League Baseball where the digital platform, PITCHf/x, implemented during 2006 and 2007 seasons facilitated the professional baseball clubs to create occupations for data analytics.

Findings
This study found that long-term low performance of organizations resulted in creating occupations for a new technology and deploying professionals to them and the public media’s negative tenor mediated the relationship between the signal of institutional inefficiency and such a boundary work in a competitive environment.

Originality/value
This research enriches our understanding of the early disperse of a new occupation in the times of the emergence of digital platform by exploring the temporal attributes of organizational performance and the role of public media as the antecedents to embedded agency.
An investigation of how physical literacy is enacted in primary physical education
Authors: Bartle Gillian 
Published: March 2023

PurposeThis research investigated how students are becoming teachers of primary school (ages 5–11) physical education (PE), using a physical literacy (PL) approach (Whitehead, 2010). Primarily methodological, the purpose was to disrupt how to investigate this topic since research highlights that the philosophy underpinning PL makes the concept difficult to operationalize (Shearer et al., 2018).Design/methodology/approachPE settings are inherently lively, and the author retained this in the analytic insights from what she called a “methodological meshwork” (Law, 2004; Ingold, 2006). Informed by phenomenology, posthumanism and sociomaterialism, data gathering included observations, interviews with artefacts, with humans, and tweets as part of the methodological meshwork. Diagrammatic presentations accompany written text, whilst also doing work in themselves (Decuypere and Simon, 2016). The author followed the actors (Adams and Thompson, 2016), thus entered the middle of data, such as lesson plan or physical education equipment.FindingsOnto-epistemological entanglements (Barad, 2007) are presented in an interweaving format. Thus, theory is discussed alongside the empirical and shows that a PL informed approach to PE is evident in multiple places-spaces.Originality/valueBroader issues are raised about methodological assumptions that inform investigations of PL and practice generally. It is hoped that these may be relevant to a wider professional audience as well as those in physical and teacher education.
Upscaling brand image: UNIQLO Japan
Authors: Taira Yuri , Hardisty David J. , Basto da Silva Rui Jorge B. 
Published: March 2023

Research methodology
The authors analyzed data and information mainly from the company’s annual reports and the books written by the CEO.

Case overview/synopsis
How and when can a “value” brand upscale its brand image? In the wake of the financial crisis of 2007–2008, UNIQLO – Japan’s street fashion brand – considered introducing a new brand collaboration. They needed to capture the attention of younger, more fashionable consumers. However, people were tightening their spending as they faced uncertainties related to their jobs and wealth. Even though UNIQLO had had a steady growth in sales for the previous 24 years, it was questionable whether it was strategically a good time to launch a premium brand collaboration. And if so, who was the right partner? High-end designer Jil Sander, fashionable New York-based Theory or emerging French “casual luxury” brand Comptoir des Cotonniers?

Complexity academic level
This case is about the challenges faced by a low-priced brand to collaborate with a high-end brand to enhance the brand image. It explores the important elements to take into consideration when evaluating launching collaboration using the high-end brand’s name. The students will learn how to examine the risks and benefits of creating a new image for the core brand. If the students had learnt branding or brand extension before, this case can be used to teach how consumer’s perception affects brand extension and the target market’s impact on pricing and distribution strategies. It can be used for a marketing course at the MBA level to explore the concepts in a growing company’s brand image or an undergraduate specialized course in brand management or marketing management. The students also learn how the fashion industry’s supply chain management works to adapt to rapidly changing fashion trends.
Business and Management Studies in the United Kingdom's 2021 Research Excellence Framework: Implications for Research Quality Assessment
Authors: Blackburn Robert , Dibb Sally , Tonks Ian 
Published: March 2023

AbstractEvaluating research is an established part of the research process, as funding agencies and governments seek to raise its quality and performance. The United Kingdom's Research Excellence Framework 2021 (REF2021) was the eighth formal assessment of research in UK universities. In Business and Management Studies (B&M), Sub‐Panel 17, 108 universities submitted 16,038 research outputs and 539 impact case studies covering the period 2014–2020. Submissions were assessed by a panel of academic researchers and research users, nominated by a range of academic constituencies. The outcome was that the quality of UK research in B&M continues to improve since REF2014. The quality profile for REF2021 had 79% of research assessed as 3* (internationally excellent) and 4* (world‐leading). The paper explains and reports on our experiences of the peer review process, analyses the outcomes and discusses the state of research within the discipline. Subsequently, we consider the wider implications of the REF process, its methodologies and impacts, contributing to the debate about research quality in universities. The paper concludes with support for peer review and expresses caution against the automation of research quality assessment.
Effect of protein–starch interactions on starch retrogradation and implications for food product quality
Authors: Scott Gabrielle , Awika Joseph M. 
Published: March 2023

AbstractStarch retrogradation is a consequential part of food processing that greatly impacts the texture and acceptability of products containing both starch and proteins, but the effect of proteins on starch retrogradation has only recently been explored. With the increased popularity of plant‐based proteins in recent years, incorporation of proteins into starch‐based products is more commonplace. These formulation changes may have unforeseen effects on ingredient functionality and sensory outcomes of starch‐containing products during storage, which makes the investigation of protein–starch interactions and subsequent impact on starch retrogradation and product quality essential. Protein can inhibit or promote starch retrogradation based on its exposed residues. Charged residues promote charge–dipole interactions between starch‐bound phosphate and protein, hydrophobic groups restrict amylose release and reassociation, while hydrophilic groups impact water/molecular mobility. Covalent bonds (disulfide linkages) formed between proteins may enhance starch retrogradation, while glycosidic bonds formed between starch and protein during high‐temperature processing may limit starch retrogradation. With these protein–starch interactions in mind, products can be formulated with proteins that enhance or delay textural changes in starch‐containing products. Future work to understand the impact of starch–protein interactions on retrogradation should focus on integrating the fields of proteomics and carbohydrate chemistry. This interdisciplinary approach should result in better methods to characterize mechanisms of interaction between starch and proteins to optimize their food applications. This review provides useful interpretations of current literature characterizing the mechanistic effect of protein on starch retrogradation.
The role of ultrasound synovitis scores for patients who are at risk of rheumatoid arthritis
Authors: Yen Tsai‐Hung , Wu Yi‐Da , Chen Hsin‐Hua , Tseng Chih‐Wei , Chen Yi‐Hsin , Chen Yi‐Ming , Lai Kuo‐Lung 
Published: March 2023

AbstractObjectivesThe development of rheumatoid arthritis (RA) has been classified into 6 phases A–F according to the present risk factors in sequence of genes, environments, autoimmunity, arthralgia and joint swelling. To clarify the ultrasound synovitis scores in at‐risk patients (phases C–E) and RA (phase F).MethodsPatients who had been experiencing hand joint symptoms for at least 6 weeks and asymptomatic patients with positive rheumatoid factor and/or anti‐cyclic citrullinated peptide antibodies were enrolled. A 40‐joint ultrasonography with semiquantitative synovitis scoring for gray scale (GS) and power Doppler (PD) images was performed.ResultsA total of 139 patients were enrolled and classified into non‐RA, phase C, phase D, phase E and phase F. Total GS scores in phases C (17.4 ± 7.0), D (16.0 ± 5.4), E (18.5 ± 7.7) and F (21.8 ± 9.1) were higher than those in non‐RA (9.8 ± 4.0, P < 0.001). The total PD score in phase F (3.1 ± 4.6) was higher than that in phases C (0.2 ± 0.5), D (0.1 ± 0.4), and E (0.1 ± 0.3), as well as in non‐RA (0.0 ± 0.0, P < 0.01). A total GS score ≥14 differentiated patients at risk for RA from patients with non‐RA (area under curve [AUC] 0.82), while a total PD score ≥2 differentiated patients with RA from patients at risk for RA (AUC 0.71).ConclusionTotal GS score may differentiate patients at risk for RA from non‐RA patients, while total PD score may differentiate patients with RA from those who are at risk for RA.
Oncogenic zinc finger protein ZNF687 accelerates lung adenocarcinoma cell proliferation and tumor progression by activating the PI3K/AKT signaling pathway
Authors: Li Mingchun , Liu Zhihua , Hou Zan , Wang Xiangcai , Shi Huaqiu , Li Yamei , Xiao Xuewen , Tang Zhixian , Yang Jianqiong , Luo Yaoling , Zhang Minhong , Chen Ming 
Published: March 2023

AbstractBackgroundZinc finger protein 687 (ZNF687) has previously been discovered as a potential oncogene in individuals with giant cell tumors of the bone, acute myeloid leukemia, and hepatocellular carcinoma. However, its role and mechanism in lung adenocarcinoma (LUAD) remain unclear.MethodsIn LUAD cells, tumor, and matched adjacent tissue specimens, quantitative real‐time RT‐ polymerase chain reaction (qRT‐PCR), western blotting analyses, and immunohistochemistry staining (IHC) were conducted. Cell counting kit‐8 (CCK8) assay, clonogenicity analysis, flow cytometry, and transwell assays were utilized to detect ZNF687 overexpression and knockdown impacts on cell growth, colony formation, cell cycle, migration, and invasion. Bioinformatic studies, qRT‐PCR and western blotting studies were employed to validate the underlying mechanisms and signaling pathways implicated in the oncogenic effect of ZNF687.ResultsThis study demonstrated that ZNF687 expression was elevated in LUAD cells and tissues. Individuals with upregulated ZNF687 had a poorer prognosis than those with downregulatedZNF687 (p < 0.001). ZNF687 overexpression enhanced LUAD growth, migration, invasion and colony formation, and the cell cycle G1‐S transition; additionally, it promoted the epithelial‐mesenchymal transition (EMT). In contrast, knocking down ZNF687 showed to have the opposite impact. Moreover, these effects were associated with the activity of the phosphatidylinositol 3‐kinase (PI3K)/protein kinase B (AKT) signaling mechanism.ConclusionZNF687 was upregulated in LUAD, and high ZNF687 expression levels are associated with poor prognoses. The activation of the PI3K/AKT signaling pathway by upregulated ZNF687 increased the proliferation of LUAD cells and tumor progression. ZNF687 may be a beneficial predictive marker and a therapeutic target in LUAD.
The disruption of white matter integrity of systemic striatal circuits in alcohol‐dependent males with physiological cue reactivity
Authors: Wu Fei , Dong Ping , Wu Guowei , Deng Jiahui , Gao Xuejiao , Song Xiaopeng , Yuan Junliang , Sun Hongqiang 
Published: March 2023

AbstractAlcohol dependence (AD) is a chronic and relapsing disorder. Conditioned cues associated with the rewarding properties of drugs could trigger motivational/physiological reactions and render subjects vulnerable to relapse. Striatal circuit dysfunction has been implicated in alcohol addiction behaviours. However, little is known about the striatal tracts structural connectivity changes underlying cue induced reactivity in AD. In our present study, we recruited 51 patients with AD; 31 individuals had physiological response. We used seed‐based classification by probabilistic tractography with nine target masks to explore the white matter integrity of striatal circuits in physiological responders (N = 31), non‐responders (N = 20), and healthy controls (N = 27). Compared with healthy controls, physiological responders showed lower fractional anisotropy (FA) and/or higher mean diffusivity in the striatum‐dorsolateral prefrontal cortex (dlPFC), striatum‐ventral lateral prefrontal cortex, striatum‐supplementary motor area (SMA), and striatum‐insular. Considering age and smoking are potential nuisances to diffusion parameters, an analysis of covariance also was conducted and similar results were found. We also found the cue‐induced physiological response was negatively associated with the FA of the striatum‐SMA (r = −0.287; p = 0.045) and left striatum‐dlPFC (r = −0.253; p = 0.079) in AD. In our study, we found abnormal integrity of striatal circuit structural connectivity in AD with physiological cue reactivity, especially trajectory from prefrontal cortex and insular. We also found the FA of striatal tracks was negatively associated with the degree of cue reactivity. Our findings provide further evidence for reduced white matter integrity of striatal circuits for cue reactivity in male individuals with AD.
Economic cost of secondary postpartum haemorrhage: A case–control study at a tertiary hospital in Australia
Authors: Young Nicole , Quinlivan Julie , Fox Rachael , Anderson Jess , Davis Laura , Mooney Samantha S. 
Published: March 2023

AbstractBackgroundSecondary postpartum haemorrhage (PPH) is a condition which affects 0.2–3.0% of women. Despite its impact on maternal morbidity, there is a lack of understanding of the cost burden of disease.AimsTo determine the economic cost of secondary PPH in the postpartum period, compared to the costs for women without this diagnosis.Materials and methodsData were prospectively collected on a cohort of 97 women who presented with secondary PPH to the emergency department (ED) between July 2020 and February 2021. A case–control design was then used to compare postpartum cost data from these patients to a group of 97 controls who were matched to maternal demographics, and who did not present with secondary PPH.ResultsFor women with secondary PPH, there were significantly more hospital attendances, and postpartum costs were higher for all cost subcategories across ED, admissions, and outpatient attendances (P < 0.0001), compared to controls. The total cost of postpartum care for 97 patients with secondary PPH was $254 377.62 with an average cost per patient of $2622.45, compared to $26 670.46 for 97 controls with an average cost of $274.95 per patient (P < 0.0001). This demonstrates a 9.5‐fold increase in postpartum costs per woman with secondary PPH.ConclusionsSecondary PPH is an under‐researched condition which presents a significant cost burden for the health system. Evidence‐based guidelines addressing the prevention and management of secondary PPH may assist in minimising this cost burden for both the health service and the patient.
Association of response time and intermittent hypoxemia in extremely preterm infants
Authors: Martin Sven , Ackermann Benjamin W. , Thome Ulrich H. , Grunwald Martin , Müller Stephanie M. 
Published: March 2023

AbstractAimTo determine the relationship between medical staff's response time (RT) to oxygen saturation (SpO2) below 80% and the associated time from tactile intervention until SpO2 normalisation (CT).MethodsTime‐lapse video and continuous SpO2 were recorded for six consecutive 24 h periods. Regression analyses of RT and SpO2 in association with postmenstrual age (PMA), weight, infant sex and frequency of intermittent hypoxemia (IH).ResultsFive hundred and twelve hypoxemia episodes received tactile intervention in 20 extremely preterm infants (gestational age ≤28 weeks, birthweight <1500 g). Median RT was 20.5 s (IQR 16.63–25.50). RT increased with increased IH frequency (p = 0.023) independently of PMA and weight. SpO2 decreased by 3.7% with every 10 s RT (p = 0.039). Time until SpO2 normalisation was strongly associated with RT (β = 0.58, p = 0.042). The association was amplified by lower PMA (p = 0.043). Female preterm infants experienced longer RT than males (p = 0.027). Because the total length of an IH is the sum of RT and CT, preterm infants with low PMA can reach a critical hypoxemia duration of >60 s, even with short RT.ConclusionThe RT is a critical factor that affects the overall time of IH treatments and the depth of desaturation. The consequences of a prolonged RT are worse for more immature preterm infants.
Breastfeeding provides a protective hug and the benefits have outweighed the risks during the COVID‐19 pandemic
Authors: Briana Despina D. , Malamitsi‐Puchner Ariadne 
Published: March 2023

AbstractMothers have been very hesitant about breastfeeding when they have COVID‐19 infection or vaccinations. Maternal milk protects neonates through its high biological value, immune factors and anti‐infectious molecules and this review shows that the virus that causes COVID‐19 is not transmitted through breast milk. COVID‐19 vaccines induce anti‐spike antibodies with neutralising capacity, and phagocytosis, and no vaccine particles or messenger ribonucleic acid have been detected in breast milk. Most drugs used for maternal COVID‐19 infections are safe for breastfed infants.ConclusionThe clear benefits of breastfeeding by far outweigh the very low risk of infant infections from COVID‐19.
Type 1 diabetes and microscopic colitis: A nationwide matched case–control study in Sweden
Authors: Kang Xiaoying , Liu Shengxin , Roelstraete Bjorn , Khalili Hamed , Ludvigsson Jonas F. 
Published: March 2023

SummaryBackground and AimsMicroscopic colitis (MC) is a colonic inflammatory condition associated with autoimmune dysfunction. Type 1 diabetes (T1D) is a chronic disease induced by autoimmune destruction of pancreatic β‐cells. We aimed to examine the association between T1D and MC.MethodsA matched case–control study was conducted using the nationwide ESPRESSO cohort as study base. All biopsy‐confirmed MC patients born after 1940 were identified and compared to biopsy‐free individuals matched from the general population for T1D diagnosis using the Swedish National Patient Register. The T1D‐MC association was estimated as odds ratios (ORs) and 95% confidence intervals (CIs) by conditional logistic models, considering differences by sex and MC subtype. Full sibling comparison and adjustment for MC‐associated medications were also performed.ResultsWe identified 352 (3.7%) and 945 (2.0%) T1D diagnoses from 9,600 MC cases and 47,870 matched population controls, respectively, which corresponded to an overall OR of 1.79 (95% CI: 1.56–2.05). The association was stronger for collagenous colitis (OR, 2.15; 95% CI: 1.70–2.71) than lymphocytic colitis (OR, 1.62; 95% CI: 1.37–1.92) and remained statistically significant in full sibling comparison (OR, 1.46; 95%: 1.18–1.81). Medication adjustment attenuated the association to null among females (OR: 1.02; 95% CI: 0.82–1.27) but not among males (OR: 1.45; 95% CI: 1.11–1.90).ConclusionT1D diagnosis was almost 80% more prevalent in MC patients compared to general population. This positive association did not seem to be spurious due to residual confounding shared by full siblings but may relate to consumption of medications associated with MC onset.