bluuebunny/crossref_metadata_2025_split huggingface dataset:
Asymmetric Synthesis of Anti‐tuberculosis‐specific Drug TBAJ‐876 through Synergistic Li/Li Catalysis
Authors: Li Jing , Gao Feng , Ahmad Tanveer , Luo Yicong , Zhang Zhenfeng , Yuan Qianjia , Zhang Wanbin 
Published: January 2023

Comprehensive SummaryTBAJ‐876, developed by TB Alliance, a novel anti‐tuberculosis‐specific drug, has entered Phase II clinical trials. Herein, the first asymmetric synthesis of TBAJ‐876 has been realized using synergistic Li/Li catalysis with excellent yield of 95% and 88 : 12 er (99.6 : 0.4 er, 10 : 1 dr after simple recrystallization). Furthermore, DFT calculations and 7Li‐NMR analysis illustrated the mechanism of the synergistic reaction: a chiral Li‐complex activates the nucleophile to control the stereoselectivity, while the other achiral Li‐complex activates the electrophile to catalyze the carbonyl addition reaction. Additionally, this protocol has been successfully carried out at 5 gram‐scale, showing its industrial potential.
Managing for stakeholders towards corporate environmental sustainability
Authors: Góes Helna Almeida de Araujo , Fatima Ghulam , Santos Jhunior Ronaldo de Oliveira , Boaventura João Maurício Gama 
Published: January 2023

AbstractThe purpose of this paper is to clarify the relationship between the managing for stakeholders approach and corporate environmental sustainability. Focused on the debates on the impacts that organizations and their stakeholders have on society's welfare, our conceptual paper proposes a rationale addressing the question: In what ways does managing for stakeholders may influence corporate environmental sustainability? To this end, we analyze previous literature on managing stakeholders focused on how firms address stakeholders' environmental concerns and previous literature on corporate sustainability focused on managing stakeholders' expectations. There is a fit between adopting a managing for stakeholders approach and encouraging firms to become more environmentally sustainable. Furthermore, our rationale argues that this approach may also influence firms to build closer relationships with stakeholders by adopting transparent practices and proactive environmental strategies, impacting synergic value creation, stakeholder engagement, and overall performance. Finally, we argue for a novel approach to link managing for stakeholders and corporate sustainability while suggesting propositions for future investigation and implications for practitioners.
Small molecule Z363 co‐regulates TAF10 and MYC via the E3 ligase TRIP12 to suppress tumour growth
Authors: Xiong Yan , Wang Lulu , Xu Shiyao , Fu Beibei , Che Yuchen , Zaky Mohamed Y. , Tian Rong , Yao Rui , Guo Dong , Sha Zhou , Lin Feng , Lin Xiaoyuan , Wu Haibo 
Published: January 2023

AbstractBackgroundThe MYC oncoprotein, also known as the master regulator of genes, is a transcription factor that regulates numerous physiological processes, including cell cycle control, apoptosis, protein synthesis and cell adhesion, among others. MYC is overexpressed in approximately 70% of human cancers. Given its pervasive role in cancer biology, MYC down‐regulation has become an attractive cancer treatment strategy.MethodsThe CRISPR/Cas9 method was used to produce KO cell models. Western blot was used to analyzed the expressions of MYC and TATA‐binding proteinassociated factors 10 (TAF10) in cancer cells (MCF7, A549, HepG2 cells) Cell culture studies were performed to determine the mechanisms by which small molecules (Z363119456, Z363) affects MYC and TAF10 expressions and functions. Mouse studies were carried out to investigate the impact of Z363 regulation on tumor growth.ResultsZ363 activate Thyroid hormone Receptor‐interacting Protein 12 (TRIP12), which phosphorylates MYC at Thr58, resulting in MYC ubiquitination and degradation and thereby regulating MYC target genes. Importantly, TRIP12 also induces TAF10 degradation, which reduces MYC protein levels. TRIP12, an E3 ligase, controls MYC levels both directly and indirectly by inhibiting MYC or TAF10 activity.ConclusionsIn summary,these results demonstrate the anti‐cancer properties of Z363, a small molecule that is co‐regulated by TAF10 and MYC.
XBP1‐elicited environment by chemotherapy potentiates repopulation of tongue cancer cells by enhancing miR‐22/lncRNA/KAT6B‐dependent NF‐κB signalling
Authors: Jia Xiaoting , Wang Ge , Wu Lihong , Pan Hao , Ling Li , Zhang Jianlei , Wen Qingquan , Cui Jie , He Zhimin , Qi Bin , Zhang Shuxu , Luo Liyun , Zheng Guopei 
Published: January 2023

AbstractBackgroundTumour repopulation initiated by residual tumour cells in response to cytotoxic therapy has been described clinically and biologically, but the mechanisms are unclear. Here, we aimed to investigate the mechanisms for the tumour‐promoting effect in dying cells and for tumour repopulation in surviving tongue cancer cells.MethodsTumour repopulation in vitro and in vivo was represented by luciferase activities. The differentially expressed cytokines in the conditioned medium (CM) were identified using a cytokine array. Gain or loss of function was investigated using inhibitors, neutralising antibodies, shRNAs and ectopic overexpression strategies.ResultsWe found that dying tumour cells undergoing cytotoxic therapy increase the growth of living tongue cancer cells in vitro and in vivo. Dying tumour cells create amphiregulin (AREG)‐ and basic fibroblast growth factor (bFGF)‐based extracellular environments via cytotoxic treatment‐induced endoplasmic reticulum stress. This environment stimulates growth by activating lysine acetyltransferase 6B (KAT6B)‐dependent nuclear factor‐kappa B (NF‐κB) signalling in living tumour cells. As direct targets of NF‐κB, miR‐22 targets KAT6B to repress its expression, but long noncoding RNAs (lncRNAs) (XLOC_003973 and XLOC_010383) counter the effect of miR‐22 to enhance KAT6B expression. Moreover, we detected increased AREG and bFGF protein levels in the blood of tongue cancer patients with X‐box binding protein‐1 (XBP1) activation in tumours under cytotoxic therapy and found that XBP1 activation is associated with poor prognosis of patients. We also detected activation of miR‐22/lncRNA/KAT6B/NF‐κB signalling in recurrent cancers compared to paired primary tongue cancers.ConclusionsWe identified the molecular mechanisms of cell death‐induced tumour repopulation in tongue cancer. Such insights provide new avenues to identify predictive biomarkers and effective strategies to address cancer progression.
The relationship between individual symptom connectivity and global eating disorder symptom severity
Authors: DuBois Russell H. , Rodgers Rachel F. , Fuller‐Tyszkiewicz Matthew , Shiyko Mariya , Franko Debra L. 
Published: January 2023

AbstractBackgroundThe network approach has emerged as a useful framework for conceptualizing and investigating psychopathology, including eating disorders. Network connectivity, that is, the density of the connections among network nodes, has been somewhat neglected despite its theoretical relevance. As predicted by network theory, symptom connectivity would be distinct but related to symptom severity and may be a useful clinical indicator of psychopathology as stronger and/or more diffuse connections among symptoms offer more avenues for symptom activation. This study aimed to investigate the relationship between moment‐by‐moment individual‐level symptom connectivity and global levels of symptom severity in the context of eating disorder symptoms and experiences.MethodsA sample of 58 female undergraduate college students, mean (SD) age = 20.5 (3.1) provided data on eating disorder symptoms eight times a day over the course of 10 days. Network analyses were used to calculate the eating disorder symptoms network connectivity for each participant. In addition, participants completed survey of self‐report measures of eating disorder symptom severity and trait mindfulness and body image flexibility.ResultsAnalyses revealed a moderate, positive relationship between individual network connectivity and eating disorder symptom severity. In addition, symptom connectivity predicted unique variance of symptom severity even after controlling for other clinically‐relevant variables.ConclusionsIndividual‐level network connectivity may be an important dimension of psychopathology and further work exploring the role of network connectivity is warranted.Public SignificanceThese findings suggest that symptom severity and the extent to which different eating disorder symptoms are connected are related but different dimensions. Investigating how these different dimensions play a role in eating disorder pathology could help to better understand and treat these disorders.
A portable wireless‐sensor system from all‐in‐one sensor array based hybrid solid contact layer for point‐of‐care ion monitoring in river basin
Authors: Qileng Aori , Peng Haihua , Yin Tongyue , Lin Xubin , Zhai Bingqian , Chong Yunxiao , Li Kangshun , Liu Yingju 
Published: January 2023

AbstractThe sensor arrays are considered as a promising way to aim at point‐of‐care (POC) testing for the detection of different ions in environment through the use of solid‐contact ion‐selective electrodes (SC‐ISEs). However, the exorbitant equipment and intricate process for the production of SC‐ISEs arrays has limit its application. Herein, the Au with nano‐branched structure (Au NBS) and poly (3,4‐ethylenedioxythiophene): poly (styrenesulfonate) (PEDOT : PSS) were decorated on the surface of bare pad of traditional printed circuit boards coated with Au (Au‐PCB) to construct a hybrid solid‐contact layer including double‐layer capacitance and pseudocapacitance of SC‐ISEs synergistically, thus the multichannel SC‐ISEs exhibited high stability and specificity. Overall, based on portable multichannel sensor and homemade APP (Ion Analysis), a wireless all‐in‐one sensor system was constructed to detect ions with the limit of NO3−, Cl−, Na+, K+, Ca2+ and Mg2+ as 0.047 mM, 0.039 mM, 0.022 mM, 0.066 mM, 0.045 mM and 0.024 mM, respectively. Besides, it can detect such ions in river basin successfully. With the cost of each electrode less than 0.5 $, this sensor arrays enable a wide range of hazardous ion monitoring in water environment.
Recycling of graphite anode from spent lithium‐ion batteries: Advances and perspectives
Authors: Qiao Yu , Zhao Huaping , Shen Yonglong , Li Liqiang , Rao Zhonghao , Shao Guosheng , Lei Yong 
Published: January 2023

AbstractThere is growing production for lithium‐ion batteries (LIBs) to satisfy the booming development renewable energy storage systems. Meanwhile, amounts of spent LIBs have been generated and will become more soon. Therefore, the proper disposal of these spent LIBs is of significant importance. Graphite is the dominant anode in most commercial LIBs. This review specifically focuses on the recent advances in the recycling of graphite anode (GA) from spent LIBs. It covers the significance of GA recycling from spent LIBs, the introduction of the GA aging mechanisms in LIBs, the summary of the developed GA recovery strategies, and the highlight of reclaimed GA for potential applications. In addition, the prospect related to the future challenges of GA recycling is given at the end. It is expected that this review will provide practical guidance for researchers engaged in the field of spent LIBs recycling.image
The impact of air quality on China's inbound tourism based on the heterogeneity of tourists' risk perception
Authors: Sun Qiong , Yu Na , Liu Zheng , Liao Bin 
Published: January 2023

AbstractThis study employs a panel econometric model to assess and examine the relationship between inbound tourism to China and air quality, using data on air quality and inbound tourism at the provincial level in China from 2013 to 2017. It also considers how travelers perceive risk. According to the findings, there has been an increase in foreign tourists visiting China since 2013. However, the air quality index's representation of domestic air quality is not encouraging. Our studies using the fixed effect model demonstrate that domestic air quality has a considerable beneficial impact on the number of inbound tourists, which is still strong when utilizing the mixed effect and random effect models; in comparison to northern China, the impact of air quality in southern China is more clear. Our studies demonstrate that the ongoing decline in China's inbound tourism scale in recent years is strongly correlated with the quality of the country's air, which is influenced by each visitor's personal preferences. In order to improve China's reputation in the global tourism market, the report concludes by outlining solutions to address this impact. These methods include maintaining the promotion of environmental governance while also tightly integrating tourism marketing.
Optimal control for maximally creating and maintaining a superposition state of a two‐level system under the influence of Markovian decoherence
Authors: Ohtsuki Yukiyoshi , Mikami Suicho , Ajiki Toru , Tannor David J. 
Published: January 2023

AbstractReducing decoherence is an essential step toward realizing general‐purpose quantum computers beyond the present noisy intermediate‐scale quantum (NISQ) computers. To this end, dynamical decoupling (DD) approaches in which external fields are applied to qubits are often adopted. We numerically study DD using a two‐level model system (qubit) under the influence of Markovian decoherence by using quantum optimal control theory with slightly modified settings, in which the physical objective is to maximally create and maintain a specified superposition state in a specified control period. An optimal pulse is numerically designed while systematically varying the values of dephasing, population decay, pulse fluence, and control period as well as using two kinds of objective functionals. The decrease in purity due to the decoherence limits the ability to maintain a coherent superposition state; we refer to the state of maximal purity that can be maintained as the saturated value. The optimally shaped pulse minimizes the negative effect of decoherence by gradually populating and continuously replenishing the state of saturated purity.
A regional and seasonal approach to explain the observed trends in the Antarctic sea ice in recent decades
Authors: Yu Lejiang , Zhong Shiyuan , Sui Cuijuan , Sun Bo 
Published: January 2023

AbstractIn contrast to the declining sea ice extent across most of the Arctic in the past several decades, sea ice extent in the Antarctic has experienced opposite regional trends with regions of sea ice expansion exceeding those of contraction. Various mechanisms have been put forward to explain the Antarctic sea ice trends, but few have been successful at explaining a large portion of the observed trends. Dividing the Southern Ocean into the Pacific, Atlantic, and Indian Ocean sectors and examining the trends over 1979–2018 separately for each sector and for each season of the year, we are able to identify modes of variability that statistically explain more than 42% of the trends in all three sectors and all four seasons. In certain sector and season, up to 94% of the trends can be explained. The leading modes of variability that explain a substantial portion of the trends appear to be related to several known climate variability modes including the Southern Annular Mode (SAM), the Pacific South American (PSA) 1 and 2, and the Zonal Wavenumber 2–6 patterns. In the Atlantic and Indian Ocean sectors, the changes in the occurrences of the main contributing modes to sea ice trends are dominated by local sea‐surface temperature (SST) variations, while in the Pacific sector, they are related to changes in global SST.
Indirect impacts of future urban expansion on ecosystem services in the transnational area of China, North Korea, and Russia
Authors: Zhang Da , Nan Ying , Zhu Weihong , He Chunyang , Liu Zhifeng , Yang Yanmin 
Published: January 2023

AbstractAssessing the indirect impacts of urban expansion on ecosystem services is important for understanding the cascading effect of urbanization on the environment. However, few studies have assessed the indirect impacts of urban expansion on ecosystem services. In this study, the indirect impacts of urban expansion on ecosystem services refer to the impacts of cropland displacement on ecosystem services, which is triggered by urban expansion. Taking the transnational area of Changbai Mountain as a study area, we assessed the indirect impacts of urban expansion on ecosystem services during 2015–2050. We first quantified three key ecosystem services, that is, carbon storage (CS), water retention (WR), and air purification (AP). Then, the future urban expansion and cropland displacement were simulated by using the Shared Socioeconomic Pathways (SSPs) and the zoned Land Use Scenario Dynamics‐urban (LUSD‐urban) model. Finally, the indirect impacts of urban expansion on ecosystem services were assessed. The results indicated that influenced by the cropland displacement, the CS, WR, and AP will decrease by 0.03%–0.16%, 0.01%–0.06%, and 0.03%–0.16%, respectively. The Democratic People's Republic of Korea's (DPRK) side will be the foremost region of ecosystem service indirect losses. The indirect losses of ecosystem services on the DPRK's side will be significantly higher than those on the Chinese side and Russian side. Meanwhile, on the DPRK's side, the indirect losses of CS and AP will be 1.01–1.74‐times and 1.01–1.67‐times the direct losses of these two ecosystem services, respectively. In addition, cropland displacement will cause significant trade‐offs between food provisioning services and regulation services. To promote sustainable development in this transnational area, we propose to make effective land‐use policies to optimize cropland displacement and take ecosystem services as effective tools to guide land‐use planning.
Study the reuse possibility of tempering lubricant for cold‐rolled strip wet‐rolling processing
Authors: Zhao Jigang , Chen Weimin , Zeng Junjian 
Published: January 2023

AbstractIn the wet rolling process of industrial cold‐rolled strips, the tempering lubricant was discarded after one‐time use, which resulted in huge waste and high costs for wastewater treatment. In order to explore the reuse value and feasibility of the tempering lubricant, the influences of industrial rolling were to be studied first. In the comparison of before and after‐use‐ tempering lubricant, the surface tension decreased by 34%, and the physicochemical indicators such as electrical conductivity, pH, and total alkali value decreased by 4%–14.3%. In terms of the components and related effects, about 15% of heavy organic matter, such as fatty acids and alcohol amine was responsible for lubrication, rust prevention, and corrosion inhibition. These heavy organic solutes would reduce by 2%–6%, with impurities increasing after rolling. However, the waste tempering lubricant still had a high reuse value. Further from the influence of impurities and microorganisms, it was concluded that if the solid powders were filtered out, the bacteriostatic agent was added after 3 days, and the changes in the effective substance concentration of the tempering lubricant were mastered to replace 1/3 of it in time during recycling, then the reuse of the tempering lubricant was feasible.
Fine‐Tuned Polymer Nanoassembly for Codelivery of Chemotherapeutic Drug and siRNA
Authors: Yuan Yuanyuan , Wang Yiyao , Huang Huiling , Tao Shuiliang , Huang Jinsheng 
Published: January 2023

AbstractSuccessful clinical application of siRNA to liver‐associated diseases reinvigorates the RNAi therapeutics and delivery vectors, especially for anticancer combination therapy. Fine tuning of copolymer‐based assembly configuration is highly important for a desirable synergistic cancer cell‐killing effect via the codelivery of chemotherapeutic drug and siRNA. Herein, an amphiphilic triblock copolymer methoxyl poly(ethylene glycol)‐block‐poly(L‐lysine)‐block‐poly(2‐(diisopropyl amino)ethyl methacrylate) (abbreviated as mPEG‐PLys‐PDPA or PLD) consisting of a hydrophilic diblock mPEG‐PLys and a hydrophobic block PDPA is synthesized. Three distinct assemblies (i.e., nanosized micelle, nanosized polymersome, and microparticle) are acquired, along with the increase in PDPA block length. Furthermore, the as‐obtained polymersome can efficiently codeliver doxorubicin hydrochloride (DOX) as a hydrophilic chemotherapeutic model and siRNA against ADP‐ribosylation factor 6 (siArf6) as an siRNA model into cancer cell via lysosomal pH‐triggered payload release. PC‐3 prostate cell is synergistically killed by the DOX‐ and siArf6‐coloading polymersome (namely PLD@DOX/siArf6). PLD@DOX/siArf6 may serve as a robust nanomedicine for anticancer therapy.
Photo‐Crosslinkable Inorganic/Organic Sulfur Polymers
Authors: Ambulo Cedric P. , Carothers Kyle J. , Hollis Ashford T. , Limburg Hannah N. , Sun Lirong , Thrasher Carl J. , McConney Michael E. , Godman Nicholas P. 
Published: January 2023

AbstractInverse vulcanization techniques are used to fabricate thermodynamically stable, sulfur polymers. Sulfur‐based polymers exhibit higher refractive indices and improved transparency in the mid‐wave infrared region compared with most organic polymers. Herein, the postsynthetic modification of sulfur polymers created via inverse vulcanization to generate novel, inorganic/organic photoresists is discussed. Amine‐containing sulfur resins are postfunctionalized with cross‐linkable alkynes. The sulfur‐based materials undergo rapid photo‐crosslinking to generate patternable films within 10 min under UV irradiation (365 nm). The development of these resins enables sulfur polymers to be utilized in processes where spatial and hierarchical control is necessary. The generation of this class of materials also expands on sulfur‐based organic polymer systems with optical applications.