bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transversal Harm and Zemiology: Reconsidering Green Criminology and Mineral Extractivism in Cerro de Pasco, Peru
Authors: Boukli Avi , Kotsakis Andreas 
Published: August 2023

AbstractGreen criminology has been advancing a focus on environmental crimes and harms. Extending this inquiry into avoidable and avertable environmental harms is a key function of both green criminology and zemiology. However, while the former seeks to expand regulatory frameworks, the latter contains within it the potential for a more holistic reimagining of the social world. Based on a methodology that combines qualitative methods (key informant interviews), a zemiological analysis, and the political ecology of Felix Guattari, we present a reconceptualization of harm inflicted by mineral extractivism in Peru’s Cerro de Pasco. The analysis utilizes the concept of transversal harm, which allows us to move beyond the criminal and civil damage of corporate crime and negligence, and to capture the collective and continuous impact of mineral extractivism. A discussion of transversal harm as a potential new avenue for expanding the conceptual boundaries of studying environmental harm concludes the article.
Safety-by-design and engineered nanomaterials: the need to move from theory to practice
Authors: Trump Benjamin D. , Antunes Dalila , Palma-Oliveira José , Nelson Andrew , Hudecova Alexandra Misci , Rundén-Pran Elise , Dusinska Maria , Gispert Ignasi , Resch Susanne , Alfaro-Serrano Beatriz , Afantitis Antreas , Melagraki Georgia , Tse Edmund C. M. , Trump Josh , Kohl Yvonne , Linkov Igor 
Published: August 2023

AbstractAs the governance of engineered nanomaterials (ENMs) evolves, innovations in the prevention, mitigation, management, and transfer of risk shape discussion of how nanotechnology may mature and reach various marketplaces. Safety-by-Design (SbD) is one leading concept that, while equally philosophy as well as risk-based practice, can uniquely help address lingering uncertainties and concerns stemming from regulatory evaluation of ENM risk across worker, consumer, and environmental safety. This paper provides a discussion on the SbD concept across different disciplines aiming to identify different approaches and needs to meet regulatory requirements—ultimately, we argue that SbD is evolving both to meet the needs and discourse of various disciplines, and to apply within differing marketplaces and national regulatory structures. Understanding how SbD has evolved within ENM can yield a more practical application and development of SbD, and help guide or unify national and international ENM governance around a core set of safety-driven principles.
Physiologically based pharmacokinetic model to predict drug–drug interactions with the antibody–drug conjugate enfortumab vedotin
Authors: Choules Mary P. , Zuo Peiying , Otsuka Yukio , Garg Amit , Tang Mei , Bonate Peter 
Published: August 2023

AbstractEnfortumab vedotin is an antibody–drug conjugate (ADC) comprised of a Nectin-4–directed antibody and monomethyl auristatin E (MMAE), which is primarily eliminated through P-glycoprotein (P-gp)–mediated excretion and cytochrome P450 3A4 (CYP3A4)–mediated metabolism. A physiologically based pharmacokinetic (PBPK) model was developed to predict effects of combined P-gp with CYP3A4 inhibitor/inducer (ketoconazole/rifampin) on MMAE exposure when coadministered with enfortumab vedotin and study enfortumab vedotin with CYP3A4 (midazolam) and P-gp (digoxin) substrate exposure. A PBPK model was built for enfortumab vedotin and unconjugated MMAE using the PBPK simulator ADC module. A similar model was developed with brentuximab vedotin, an ADC with the same valine-citrulline–MMAE linker as enfortumab vedotin, for MMAE drug–drug interaction (DDI) verification using clinical data. The DDI simulation predicted a less-than-2-fold increase in MMAE exposure with enfortumab vedotin plus ketoconazole (MMAE geometric mean ratio [GMR] for maximum concentration [Cmax], 1.15; GMR for area under the time-concentration curve from time 0 to last quantifiable concentration [AUClast], 1.38). Decreased MMAE exposure above 50% but below 80% was observed with enfortumab vedotin plus rifampin (MMAE GMR Cmax, 0.72; GMR AUClast, 0.47). No effect of enfortumab vedotin on midazolam or digoxin systemic exposure was predicted. Results suggest that combination enfortumab vedotin, P-gp, and a CYP3A4 inhibitor may result in increased MMAE exposure and patients should be monitored for potential adverse effects. Combination P-gp and a CYP3A4 inducer may result in decreased MMAE exposure. No exposure change is expected for CYP3A4 or P-gp substrates when combined with enfortumab vedotin.ClinicalTrials.gov identifier Not applicable.
Repurposing of approved antivirals against dengue virus serotypes: an in silico and in vitro mechanistic study
Authors: Rashmi S. H. , Disha K. Sai , Sudheesh N. , Karunakaran Joseph , Joseph Alex , Jagadesh Anitha , Mudgal P. P. 
Published: August 2023

AbstractDengue is an emerging, mosquito-borne viral disease of international public health concern. Dengue is endemic in more than 100 countries across the world. However, there are no clinically approved antivirals for its cure. Drug repurposing proves to be an efficient alternative to conventional drug discovery approaches in this regard, as approved drugs with an established safety profile are tested for new indications, which circumvents several time-consuming experiments. In the present study, eight approved RNA-dependent RNA polymerase inhibitors of Hepatitis C virus were virtually screened against the Dengue virus polymerase protein, and their antiviral activity was assessed in vitro. Schrödinger software was used for in silico screening, where the compounds were passed through several hierarchical filters. Among the eight compounds, dasabuvir was finally selected for in vitro cytotoxicity and antiviral screening. Cytotoxicity profiling of dasabuvir in Vero cells revealed changes in cellular morphology, cell aggregation, and detachment at 50 μM. Based on these results, four noncytotoxic concentrations of dasabuvir (0.1, 0.25, 0.5, and 1 µM) were selected for antiviral screening against DENV-2 under three experimental conditions: pre-infection, co-infection, and post-infection treatment, by plaque reduction assay. Viral plaques were reduced significantly (p < 0.05) in the co-infection and post-infection treatment regimens; however, no reduction was observed in the pretreatment group. This indicated a possible interference of dasabuvir with NS5 RdRp, as seen from in silico interaction studies, translating into a reduction in virus plaques. Such studies reiterate the usefulness of drug repurposing as a viable strategy in antiviral drug discovery.
Graphical Abstract
In this drug repurposing study, dasabuvir, a known anti-hepatitis C drug, was selected through virtual screening and assessed for its anti-dengue activity.
Luteolin Protects Against 6-Hydoroxydopamine-Induced Cell Death via an Upregulation of HRD1 and SEL1L
Authors: Nishiguchi Hiroki , Omura Tomohiro , Sato Ayaka , Kitahiro Yumi , Yamamoto Kazuhiro , Kunimasa Junichi , Yano Ikuko 
Published: August 2023

AbstractParkinson’s Disease (PD) is caused by many factors and endoplasmic reticulum (ER) stress is considered as one of the responsible factors for it. ER stress induces the activation of the ubiquitin-proteasome system to degrade unfolded proteins and suppress cell death. The ubiquitin ligase 3-hydroxy-3-methylglutaryl-coenzyme A reductase degradation 1 (HRD1) and its stabilizing molecule, the suppressor/enhancer lin-12-like (SEL1L), can suppress the ER stress via the ubiquitin-proteasome system, and that HRD1 can also suppress cell death in familial and nonfamilial PD models. These findings indicate that HRD1 and SEL1L might be key proteins for the treatment of PD. Our study aimed to identify the compounds with the effects of upregulating the HRD1 expression and suppressing neuronal cell death in a 6-hydroxydopamine (6-OHDA)-induced cellular PD model. Our screening by the Drug Gene Budger, a drug repositioning tool, identified luteolin as a candidate compound for the desired modulation of the HRD1 expression. Subsequently, we confirmed that low concentrations of luteolin did not show cytotoxicity in SH-SY5Y cells, and used these low concentrations in the subsequent experiments. Next, we demonsrated that luteolin increased HRD1 and SEL1L mRNA levels and protein expressions. Furthermore, luteolin inhibited 6-OHDA-induced cell death and suppressed ER stress response caused by exposure to 6-OHDA. Finally, luteolin did not reppress 6-OHDA-induced cell death when expression of HRD1 or SEL1L was suppressed by RNA interference. These findings suggest that luteolin might be a novel therapeutic agent for PD due to its ability to suppress ER stress through the activation of HRD1 and SEL1L.
Looks Like a Leader: Measuring Evolution in Gendered Politician Stereotypes
Authors: van der Pas Daphne , Aaldering Loes , Bos Angela L. 
Published: August 2023

AbstractPrevious research showed that the stereotype of women politicians is incongruent with the general politician stereotype, which can be disadvantageous for women seeking political office. Based on the strong influx of women politicians in US politics, and the increased familiarity of the electorate with women in political leadership positions, we expect that voters now have a clearer picture of women politicians and that their stereotype is more congruent with the traits desired in political leaders. In testing this, we make a methodological contribution to the study of stereotyping by adapting a large-N list experiment as an effective and innovative measurement of stereotype endorsement. The results show important changes in gendered political stereotypes over the last ten years. The evolution of the women politician stereotype is encouraging: the traits that people associate with women politicians are more positive than ten years ago and more congruent to desirable traits for politicians. However, the findings also underscore the continuing masculinity of the political domain, by the strong overlap between the stereotype of men politicians and politicians in general. Even more pronounced than the positive trend for women politicians is the unfavorable evolution of the stereotypes of men politicians and politicians generally, which shows a strong downfall compared to a decade ago.
Firm performance, imperfect competition, and corruption risks in procurement: evidence from Swedish municipalities
Authors: Wittberg Emanuel , Fazekas Mihály 
Published: August 2023

AbstractPrevious research has shown that corruption risks may distort market incentives in high-risk contexts. However, there is a dearth of evidence on the potential impact of corruption in settings characterized by low corruption and high-quality institutions. Against that background, this paper delves deeper into the alleged consequences of corruption by examining the link between corruption risks in public procurement and the profitability of firms in the Swedish construction industry. We introduce a novel measure of corruption risk based on the share of single bidder contracts that a firm has won. Validity analysis confirms that our measure is correlated with an alternative corruption measure and local tender winners. Our results reveal that firms that win many single bidder contracts have higher profitability than other firms in the sector: 10 percentage points higher single bidding rate firms have a 0.2–0.6-percentage-point higher sales margin. The findings underscore that public procurement corruption risks distort markets and economic incentives, and that this risk is present even in low-corruption contexts such as in Sweden.
Do firms follow the SEC’s confidential treatment protocols? Evidence from credit agreements
Authors: Saavedra Daniel 
Published: August 2023

AbstractI examine whether firms follow the Securities and Exchange Commission’s confidential treatment protocols when redacting potentially material information from their credit agreements. My findings suggest that most firms may not comply with SEC directives: they withhold potentially material information without following the SEC’s confidential treatment protocols and without making interested parties aware of their information disadvantage. I also find evidence consistent with lender and borrower incentives driving the decision to withhold potentially material information from the credit agreement. My findings are consistent with lenders influencing redaction decisions not out of concern about rivals but because they do not want their other borrowers to see the terms. Finally, I find that the Refinitiv / LPC Dealscan database rarely includes redacted fee data, thus leading to potential biases when fees are included in cost of debt measures.
The home literacy environment and television exposure as mediators between migration background and preschool children’s linguistic abilities
Authors: Valcárcel Jiménez María , Wirth Astrid , Birtwistle Efsun , Niklas Frank 
Published: August 2023

AbstractThe development of key linguistic abilities is essential for young children and their academic success at school, in particular for children with a migration background who are at a greater risk of developing language deficits. Here, family interactions can provide valuable opportunities to support children’s linguistic learning within the Home Literacy Environment (HLE). Although the importance of the HLE for children’s language acquisition has often been investigated, research has not focused on specific facets of the HLE and other influencing factors that may be associated with early linguistic abilities such as television exposure (TE). A sample of 190 preschool children (Mage= 63.58 months, SDage = 4.42) was used to analyse the associations of the facets of the HLE and TE with children’s early linguistic abilities, namely phonological awareness (PA), vocabulary, and letter knowledge. In particular, this study aims to understand the role of the HLE facets and TE as potential mediators between migration background and children’s early linguistic abilities, when controlling for socioeconomical status (SES), children’s sex and age. The findings indicate that the association between migration background and children’s early linguistic abilities was fully mediated by all four facets of the HLE and by TE. Consequently, these mediators may be good targets for intervention and the support of preschool children’s linguistic development.
Does a Longer Work Horizon Affect Offsprings' Labour Market Outcomes?
Authors: Chattopadhyay Debdeep 
Published: August 2023

AbstractThis paper studies the effect of an increase in the work horizon of middle aged workers on the school-work transition of their offsprings aged 15–29 years. I exploit the variation in the parental work horizon induced by the 2012 Fornero reform in Italy that abruptly changed the age and years of social security contribution requirements for pension eligibility. Utilising a difference-in-difference strategy in a multi-valued treatment setting, the study shows that the reform-induced increase in the work horizon of mothers caused an increase in the probability of their offsprings seeking their first job and a decrease in these offsprings’ probability of being a student. This effect is higher among offsprings who are male, those aged 15–21, those with mothers without a University degree and those in southern Italy. Fathers did not significantly affect the student status or any labour market outcomes of their offsprings. Mechanisms behind these findings include the longer reform-induced work horizon for mothers vs. fathers, and the consequent positive effect on mothers’ lifetime earnings.
Two in One: A New Tool to Combine Two Rankings Based on the Voronoi Diagram
Authors: Mariani Francesca , Ciommi Mariateresa , Recchioni Maria Cristina 
Published: August 2023

AbstractIn this paper, we propose a novel method for ranking items such as countries, individuals, or firms based on two indices. This approach is particularly useful when constructing a composite indicator that combines both dimensions is not feasible. The proposed ranking approach involves an iterative scheme where the Voronoi algorithm is applied in a two-dimensional space at each step. To provide empirical evidence that our approach works satisfactorily, we applied the Voronoi-based iterative scheme to rank 34 European countries based on two dimensions: the Human Development Index (HDI) and the Happiness Index (HI). The correlation coefficient between the rankings based on HDI and HI is lower than the correlation coefficients between the Voronoi-based ranking and HDI, as well as between the Voronoi-based ranking and HI. These results suggest that the new method is capable of better capturing the information from both original indices.
Flow Field Characterisation of Gaseous Flow in a Packed Bed by Particle Image Velocimetry
Authors: Velten C. , Zähringer K. 
Published: August 2023

AbstractPacked beds with gaseous flow are used in many industrial processes with high energy and resource consumption. This study provides velocity data of the gas flow through a model packed bed of 40 mm spheres arranged in body centred cubic packing obtained by Particle Image Velocimetry to allow for validation of numerical calculations which are often used for process optimization. Results are presented exemplarily for a particle Reynolds number range from 200 to 500. The flow fields are discussed in terms of inlet conditions to the empty reactor, symmetry and height independent flow structure above the bed and measurements in the optically accessible interstices of the bed. The measurement of a sufficient number of snap-shots for each measurement condition and location allowed also for the determination of the turbulent kinetic energy. Above the bed, low frequency oscillations of the flow are observed, that increase with the Reynolds number. In the interior of the bed, fluctuations are much less pronounced. The appearing flow structures are not significantly influenced by different particle Reynolds numbers, but the velocity magnitude changes.
Electromyographic activity of hip extensor muscles during Nordic hamstring and razor curl exercises on leveled and inclined shanks
Authors: Soga Toshiaki , Hakariya Nadaka , Saito Hiromi , Nakaichi Naoto , Akiyama Kei , Hirose Norikazu 
Published: August 2023

Abstract
Background
Changes in electromyographic (EMG) activity of hip extensor muscles and knee flexion angles at peak biceps femoris long head (BFlh) EMG activity by different shank angles during razor curl (RC) exercises are unknown.

Aims
We investigated the changes in EMG activity of hip extensor muscles and knee flexion angle at peak BFlh EMG activity with different shank angles during RC and also compared the Nordic hamstring (NH) and RC exercises in the EMG activity of hip extensor muscles.

Methods
Twelve male university students randomly performed two repetitions of NH and RC with the lower leg slope angle set at 0° (NH0, RC0) and 40° (NH40, RC40). The EMG activity of hip extensor muscles was measured at the BFlh and related muscles. EMG activity was calculated based on the peak value of the root mean square, normalized as a percentage of the maximum voluntary isometric contraction.

Results
The BFlh EMG activity of NH0 was higher than that of RC0 (p = 0.002) and RC40 (p = 0.008). The knee flexion angle at peak BFlh EMG activity of NH0 was larger than that of NH40 (p = 0.003) and RC40 (p = 0.002), and RC0 was larger than that of NH40 (p = 0.002) and RC40 (p = 0.002).

Conclusion
NH40, the BFlh EMG activity equivalent to NH0, might be more effective for preventing recurrence of hamstring injury because the knee flexion angle at peak BFlh EMG activity remains within 30°, combined with a high BFlh EMG activity.
Systematic study of the synergistic and kinetics effects on the removal of contaminants of emerging concern from water by ultrasound in the presence of diverse oxidants
Authors: Estrada-Flórez Sandra E. , Serna-Galvis Efraím A. , Lee Judy , Torres-Palma Ricardo A. 
Published: August 2023

AbstractThe enhancement of the ultrasound system by adding diverse oxidants to remove a model contaminant (acetaminophen, ACE) in water was investigated. Different parameters were evaluated to study their effect on both the degradation kinetics and the synergy of the combination. The variables studied were the ultrasonic frequency (575, 858, and 1135 kHz), type of oxidant (hydrogen peroxide, sodium peroxydisulfate (or persulfate, PDS), and potassium peroxymonosulfate (PMS)), ACE concentration (4, 8, and 40 µM), and oxidant concentration (0.01, 0.1, 1, and 5 mM). Particular interest was placed on synergistic effects, implying that one process (or both) is activated by the other to lead to greater efficiency. Interestingly, the parameters that led to the higher synergistic effects did not always lead to the most favorable degradation kinetics. An increase in ACE removal of 20% was obtained using the highest frequency studied (1135 kHz), PMS 0.1 mM, and the highest concentration of ACE (40 µM). The intensification of degradation was mainly due to the ability of ultrasound to activate oxidants and produce extra hydroxyl radicals (HO•) or sulfate radicals (SO4•–). Under these conditions, treatment of ACE spiked into seawater, hospital wastewater, and urine was performed. The hospital wastewater matrix inhibited ACE degradation slightly, while the urine components inhibited the pollutant degradation completely. The inhibition was mainly attributed to the competing organic matter in the effluents for the sono-generated radical species. On the contrary, the removal of ACE in seawater was significantly intensified due to “salting out” effects and the production of the strong oxidant HOCl from the reaction of chloride ions with PMS.