bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimization of lead-free CsSnI3-based perovskite solar cell structure
Authors: Arbouz Hayat 
Published: February 2023

Abstract
Perovskites are considered the most promising material for the latest generation of solar cells. However, due to the presence of lead in their composition, the development of non-toxic Perovskite cells has become an essential goal to enable their large-scale production. In this work, we have simulated, modeled and optimized the structure of a single solar cell that consists of a non-toxic cesium–tin–iodine CsSnI3 Perovskite absorber with a low band gap energy value of 1.3 eV, between TiO2 and PTAA materials as ETL and HTL layers, respectively. A simulation model describing the charge carrier processes and the effect of interface defect density is presented. Several structures based on alternative ETL and HTL materials are proposed. An optimal device structure is proposed based on the results obtained. An efficiency of 19.92% is obtained with V
oc = 0.829 V, J
sc = 30.68 mA/cm2 and FF = 73.33% using SnO2 and Spiro-OMeTAD as ETL and HTL materials. However, 29.22% is achieved using the optimal structure as the bottom cell in a tandem configuration.
Single-cell transcription analysis reveals the tumor origin and heterogeneity of human bilateral renal clear cell carcinoma
Authors: Wan Zhengqiang , Wang Yinglei , Li Aiqun , Li Cheng , Zheng Dongbing 
Published: February 2023

Abstract
Bilateral renal clear cell carcinoma (BRCC) is a rare type of renal cell carcinoma (RCC) that accounts for only 1–5% of RCC cases and has a poor clinical prognosis. The origin, tumor microenvironment, cellular molecular features, and intra-tumoral heterogeneity of BRCC are still unclear. We downloaded BRCC single-cell transcriptome sequencing data from the gene expression omnibus database biochip GSE171306, containing 3,575 cells from left-sided clear cell renal cell carcinoma (ccRCC) and 3,568 cells from right-sided ccRCC, and used a series of R packages for data quality control (QC) and subsequent analysis of BRCC single-cell transcriptome data, including the use of the R packages Seurat and scCancer for cell QC, identification of major cell types, and cell annotation; R package scran for calculation of cell cycle scores; R package infercnv for malignancy scoring of tumor cells; R package ReactomeGSA for functional enrichment analysis; R package Monocle 2 for the analysis of cell differentiation trajectories; and R package CellphoneDB for the analysis of intercellular interactions. In this study, by analyzing the high-quality single-cell transcriptome data of BRCC, we identified 18 cell types and found that left- and right-sided ccRCC were approximately the same in terms of cell type and the number of each cell but differed significantly in terms of tumor cell malignancy score, tumor microenvironment, and cell stemness score. In the cell differentiation trajectory analysis of BRCC, we found that endothelial cells and macrophages play an extremely important role in its tumor progression. Further cell communication analysis was performed, and we found that it may signal through ligand–receptors, such as vascular endothelial growth factor–vascular endothelial growth factor receptor1 (VEGF–VEGFR1), MIF–(CD74-CXCR4), and growth arrest-specific protein 6–AXL, to influence the development of BRCC. The analysis of single-cell transcriptomic data of human BRCC suggests that left- and right-sided ccRCC may be of the same tumor origin, but the left-sided ccRCC is more malignant and has a better immune response.
Optimization of machining Nilo 36 superalloy parameters in turning operation
Authors: Basmacı Gültekin 
Published: February 2023

Abstract
In this study, the effects of cutting speed, tool geometry, and machining parameters on surface roughness and cutting forces in the turning of Nilo 36 superalloy have been investigated. An experimental design of the turning process was made with the Taguchi technique. In this way, optimum values were estimated with a small number of experiments. The grey correlation analysis method was used to determine the best parameter levels and plausible factors. While the most ideal value for the cutter with traditional geometry was achieved with experiment number 3, indicated by the GRA (grey relationship analysis) Rank value no. 1, the worst result was obtained with experiment number 9, and while the most ideal value for the cutter with wiper geometry was achieved with experiment number 2, indicated by the GRA Rank value no. 1, the worst result was obtained with experiment number 6. Results showed that experiments made by GRA-based parameters give better results on surface roughness and cutting forces.
3D FE modeling of cable-stayed bridge according to ICE code
Authors: Ibrahim Mohammed Khaleel , Gügöş Mehmet Tolga , Abbu Muthanna , Al-Gburi Majid 
Published: February 2023

Abstract
This article presents the performance of cable-stayed bridge by representing a model using the ANSYS program under the influence of a concentrated load and then comparing them with the experimental results. One model was used in the analytical, and one was (harp type 1) used in the length of the girder (4,500 mm), height of the pylon (1,480 mm), and depth of the flange for the girder (40 mm). If cable-stayed bridges are constructed using the balanced cantilever method, the stability problem of the girder is more significant during the construction stage than at the initial state. In this study, to investigate the ultimate behavior of cable-stayed bridges, experimental and analytical studies were conducted for one model: Harp type 1. At the limit state, several plastic hinges occurred and the girders buckle along the entire span. Numerical analysis was conducted for the experimental model, and the results of which showed good agreement with the experimental results. The influence of such kind of effects on the analysis and the structural behavior of cable-stayed bridges has been examined in detail in the study. The dimensions of the model were also compared with institute civil engineering Code in terms of the height of the tower to the main space, and Back Span to the main span ratio. It was close to standard specifications. A finite element procedure for the nonlinear analysis of cable-stayed bridges is first set up, and then, a detailed static deflection analysis of such bridges is carried out.
Electric vehicle charging pile capacity planning based on normal distribution Monte Carlo sampling model
Authors: Zhang Chao , Shen Hongtao , Tao Peng , Zhang Yangrui , Han Guinan 
Published: February 2023

Abstract
In recent years, environmental issues have gradually become one of the most concerning issues in the world. New energy vehicles have attracted wide attention by their good environmental and social benefits such as zero exhaust emissions and low noise pollution. This paper proposes a regional charging demand forecasting method for electric vehicles (EVs) based on hierarchical charging decision model to solve the problem of charging pile capacity planning, which affects the charging decision behavior of EVs users. The Monte Carlo sampling model is adopted to obtain the time distribution of electric vehicle arriving at each functional area, the distribution of battery state of charge when arriving, and the distribution of average daily mileage. The negative exponential distribution model is used to obtain the average mileage distribution. The fuzzy system theory is proposed to calculate the charging probability, and the fuzzy rule base is adjusted according to the actual data to ensure that the fuzzy rule base is real and effective. Finally, the charging demand distribution curve of electric vehicles in each functional area is obtained by sampling simulation. Through experimental analysis, optimizing the capacity configuration of charging facilities in the station can well describe how electric vehicle users make charging decisions in the actual situation. The research on electric vehicle charging stations can slow down the waiting time of electric vehicle charging, and then affect the process of replacing fuel vehicles with electric vehicles to achieve the development goal of popularizing electric vehicles. It is of great significance for the promotion of new energy vehicles to rationally plan the location and capacity of electric vehicle charging stations.
IABSE-ADIAB – IAB Job Vacancy Survey Data Linked to Administrative Data
Authors: Lochner Benjamin 
Published: February 2023

Abstract
The IABSE-ADIAB dataset provides the linkage between the most recent case of a hire from the IAB Job Vacancy Survey and the administrative data of the hired person. The data comprise the entire working history of persons who were identified as IAB Job Vacancy Survey hires from 2010 to 2020. The data are processed in a similar manner to the Sample of Integrated Employment Biographies of the IAB and can be linked to the survey data using the provided unique key variable.
Prolonging exciton lifetime of WSe2 monolayer through image dipole interaction leading to huge enhancement of photocurrent
Authors: Lee Kwang Jin , So Jae-Pil , Chamoli Sandeep Kumar , Lee Hoo-Cheol , Park Hong-Gyu , Cho Minhaeng 
Published: February 2023

Abstract
Two-dimensional transition metal dichalcogenides (2D TMDs) have been demonstrated as one of the most outstanding materials not only for fundamental science but also for a wide range of photonic applications. However, an efficient way to control their excitonic properties is still needed for advanced applications with superior device performance. Here, we show that the exciton lifetime of WSe2 monolayer can be prolonged using metamaterials. We observe a ∼100% reduction in the electron-hole recombination rate of WSe2 monolayer placed on a hyperbolic metamaterial substrate and demonstrate that such a remarkable change results from the destructive image dipole interaction with the in-plane exciton transition dipole. Furthermore, this substantial increase in exciton lifetime leads to order-of-magnitude (10-fold) enhancement of photocurrent in the 2D WSe2-based hybrid photodetector with metamaterials. Tailoring the optical transition properties of 2D TMD materials with specially designed metamaterials, demonstrated here, will pave the way for developing 2D material-based optoelectronics.
Disruptive Veränderungen in der Automobilindustrie bedingen neue Entwicklungsprozesse
Authors: Eigner Martin 
Published: February 2023

Abstract
Im vorliegenden ersten Teil dieses Beitrags werden die auftretenden Veränderungen in der Automobilindustrie, die durch die Trends Connectivity, Autonomeous Driving, Shared Mobility und Electric Vehicles hervorgerufen werden, adressiert. Diskutiert werden auch die Herausforderungen, Konsequenzen, bestehende und neue Geschäftsmodelle für die Lieferketten über den gesamten Produktlebenszyklus (PLZ). Für die Bewältigung der genannten Punkte thematisiert der Autor ein Konzept basierend auf dem Model-based Systems Engineering Ansatz und neuen innovativen Technologien, hervorgerufen durch die Digitalisierung, um das Engineering weiterzuentwickeln.
Neurovascular Development inPtenandTsc2Mouse Mutants
Authors: Dusing Mary , LaSarge Candi L. , White Angela , Jerow Lilian G. , Gross Christina , Danzer Steve C. 
Published: February 2023

AbstractHyperactivation of the mechanistic target of rapamycin (mTOR) signaling pathway is linked to more than a dozen neurologic diseases, causing a range of pathologies, including excess neuronal growth, disrupted neuronal migration, cortical dysplasia, epilepsy and autism. The mTOR pathway also regulates angiogenesis. For the present study, therefore, we queried whether loss ofPtenorTsc2, both mTOR negative regulators, alters brain vasculature in three mouse models: one withPtenloss restricted to hippocampal dentate granule cells [DGC-Ptenknock-outs (KOs)], a second with widespreadPtenloss from excitatory forebrain neurons (FB-PtenKOs) and a third with focal loss ofTsc2from cortical excitatory neurons (f-Tsc2KOs). Total hippocampal vessel length and volume per dentate gyrus were dramatically increased in DGC-Ptenknock-outs. DGC-Ptenknock-outs had larger dentate gyri overall, however, and when normalized to these larger structures, vessel density was preserved. In addition, tests of blood-brain barrier integrity did not reveal increased permeability. FB-PtenKOs recapitulated the findings in the more restricted DGC-PtenKOs, with increased vessel area, but preserved vessel density. FB-PtenKOs did, however, exhibit elevated levels of the angiogenic factor VegfA. In contrast to findings withPten, focal loss ofTsc2from cortical excitatory neurons produced a localized increase in vessel density. Together, these studies demonstrate that hypervascularization is not a consistent feature of mTOR hyperactivation models and suggest that loss of different mTOR pathway regulatory genes exert distinct effects on angiogenesis.
Model-Based Approach Shows ON Pathway Afferents Elicit a Transient Decrease of V1 Responses
Authors: St-Amand David , Baker Curtis L. 
Published: February 2023

Neurons in the primary visual cortex (V1) receive excitation and inhibition from distinct parallel pathways processing lightness (ON) and darkness (OFF). V1 neurons overall respond more strongly to dark than light stimuli, consistent with a preponderance of darker regions in natural images, as well as human psychophysics. However, it has been unclear whether this “dark-dominance” is because of more excitation from the OFF pathway or more inhibition from the ON pathway. To understand the mechanisms behind dark-dominance, we record electrophysiological responses of individual simple-type V1 neurons to natural image stimuli and then train biologically inspired convolutional neural networks to predict the neurons' responses. Analyzing a sample of 71 neurons (in anesthetized, paralyzed cats of either sex) has revealed their responses to be more driven by dark than light stimuli, consistent with previous investigations. We show that this asymmetry is predominantly because of slower inhibition to dark stimuli rather than to stronger excitation from the thalamocortical OFF pathway. Consistent with dark-dominant neurons having faster responses than light-dominant neurons, we find dark-dominance to solely occur in the early latencies of neurons' responses. Neurons that are strongly dark-dominated also tend to be less orientation-selective. This novel approach gives us new insight into the dark-dominance phenomenon and provides an avenue to address new questions about excitatory and inhibitory integration in cortical neurons.SIGNIFICANCE STATEMENTNeurons in the early visual cortex respond on average more strongly to dark than to light stimuli, but the mechanisms behind this bias have been unclear. Here we address this issue by combining single-unit electrophysiology with a novel machine learning model to analyze neurons' responses to natural image stimuli in primary visual cortex. Using these techniques, we find slower inhibition to light than to dark stimuli to be the leading mechanism behind stronger dark responses. This slower inhibition to light might help explain other empirical findings, such as why orientation selectivity is weaker at earlier response latencies. These results demonstrate how imbalances in excitation versus inhibition can give rise to response asymmetries in cortical neuron responses.
Epilepsy-Related CDKL5 Deficiency Slows Synaptic Vesicle Endocytosis in Central Nerve Terminals
Authors: Kontaxi Christiana , Ivanova Daniela , Davenport Elizabeth C. , Kind Peter C. , Cousin Michael A. 
Published: February 2023

Cyclin-dependent kinase-like 5 (CDKL5) deficiency disorder (CDD) is a severe early-onset epileptic encephalopathy resulting mainly fromde novomutations in the X-linkedCDKL5gene. To determine whether loss of presynaptic CDKL5 function contributes to CDD, we examined synaptic vesicle (SV) recycling in primary hippocampal neurons generated fromCdkl5knockout rat males. Using a genetically encoded reporter, we revealed that CDKL5 is selectively required for efficient SV endocytosis. We showed that CDKL5 kinase activity is both necessary and sufficient for optimal SV endocytosis, since kinase-inactive mutations failed to correct endocytosis inCdkl5knockout neurons, whereas the isolated CDKL5 kinase domain fully restored SV endocytosis kinetics. Finally, we demonstrated that CDKL5-mediated phosphorylation of amphiphysin 1, a putative presynaptic target, is not required for CDKL5-dependent control of SV endocytosis. Overall, our findings reveal a key presynaptic role for CDKL5 kinase activity and enhance our insight into how its dysfunction may culminate in CDD.SIGNIFICANCE STATEMENTLoss of cyclin-dependent kinase like 5 (CDKL5) function is a leading cause of monogenic childhood epileptic encephalopathy. However, information regarding its biological role is scarce. In this study, we reveal a selective presynaptic role for CDKL5 in synaptic vesicle endocytosis and that its protein kinase activity is both necessary and sufficient for this role. The isolated protein kinase domain is sufficient to correct this loss of function, which may facilitate future gene therapy strategies if presynaptic dysfunction is proven to be central to the disorder. It also reveals that a CDKL5-specific substrate is located at the presynapse, the phosphorylation of which is required for optimal SV endocytosis.
Perceived Stress, Self-Compassion, dan Suicidal Ideation pada Mahasiswa
Authors: Febriana Yane , Purwono Urip , Djunaedi Achmad 
Published: February 2023

Suicidal ideation pada mahasiswa menjadi salah satu masalah kesehatan mental yang berdampak negatif terhadap fungsi-fungsi kehidupan termasuk meningkatkan resiko perilaku bunuh diri. Akan tetapi penelitian mengenai suicidal ideation belum banyak ditemukan di Indonesia. Berbagai teori suicidality menjelaskan perceived stress sebagai faktor kerentanan individu untuk memiliki ide bunuh diri. Meskipun demikian, tidak semua mahasiswa yang mengalami stress pada akhirnya memikirkan untuk bunuh diri. Penelitian ini bertujuan untuk melihat hubungan antara perceived stress dengan suicidal ideation yang dimoderasi self-compassion. Pengambilan data dilakukan kepada 261 mahasiswa aktif di perguruan tinggi dengan menggunakan Perceived Stress Scale, Self-compassion Scale, dan Suicidal Ideation Scale. Analisis statistik digunakan untuk menguji peran moderasi. Hasil penelitian menunjukan bahwa hipotesis diterima, yakni terdapat efek moderasi self-compassion terhadap hubungan antara perceived stress dengan suicidal ideation (b3= -.019, R2= 0.424, p.05). Self-compassion, khususnya komponen common humanity dan mindfulness dapat melemahkan hubungan antara perceived stress dengan suicidal ideation. Peranan perceived stress terhadap kemunculan suicidal ideation tergantung dari self-compassion yang dimiliki individu. Jika mahasiswa memiliki self-compassion yang tinggi maka kecenderungan persepsi stress berkembang menjadi ide bunuh diri menjadi berkurang.Suicidal ideation among college students was a mental health problem that caused negative impact to various life functions and also increasing suicide risk. Unfortunately, studies regarding suicidal ideation were still scarce in Indonesia. Various suicidality theories explained perceived stress as an individual's vulnerability factor to have suicidal ideation. Even so, not all college students who experience stress would develop suicidal ideation. The purpose of this study was to investigate the relationship between perceived stress and suicidal ideation moderated by self-compassion. Data collection was done on 261 active college students using Perceived Stress Scale, Self-compassion Scale and Suicidal Ideation Scale. Statistical analysis was used to test the moderation effect. The results support the notion that self-compassion act as moderating variable in relationship between perceived stress and suicidal ideation (b3= -.019, R2= 0.424, p.05). One's self-compassion especially common humanity and mindfulness had potential role for weaken the relationship between perceived stress and suicidal ideation. These findings highlighted the importance of self-compassion among college students. If a college student has a high level of self-compassion, the tendency of perceived stress developing into suicidal ideation will be reduced.
miR-23b-3p regulates human endometrial epithelial cell adhesion implying a role in implantation
Authors: Barton Siena , Zhou Wei , Santos Leilani L , Menkhorst Ellen , Yang Guannan , Tinn Teh Wan , Ang Catarina , Lucky Tarana , Dimitriadis Evdokia 
Published: February 2023

In brief
miR-23b-3p expression is increased in fertile endometrium during receptivity. This study investigates the function of miR-23b-3p on endometrial adhesion and its downstream targets.

Abstract
The human endometrium undergoes dramatic remodeling throughout the menstrual cycle that is essential for successful blastocyst attachment and implantation in the mid-secretory (receptive) phase. microRNA (miR) plays a role in the preparation of endometrial receptivity. miR-23b-3p expression is increased in fertile endometrium during receptivity. Here, we aimed to investigate miR-23b-3p function during receptivity. qPCR and in situ hybridization were used to investigate the expression and localization of miR-23b-3p in human endometrium, respectively. Ishikawa cells (endometrial epithelial cell line) and endometrial organoid-derived epithelial cells were transfected with miR-23b-3p mimic, and trophoblast progenitor spheroid (blastocyst surrogate) adhesion assay was used to determine effects on blastocyst adhesion to endometrial cells. We demonstrated that miR-23b-3p was significantly upregulated in the fertile endometrium of the receptive phase compared to the non-receptive, proliferative phase. No difference was identified for the expression of miR-23b-3p between fertile and infertile mid-secretory phase endometrium. miR-23b-3p localized to the epithelium and stroma in the mid-secretory phase but was undetectable in the proliferative phase of fertile endometrium. Functionally, miR-23-3p overexpression in Ishikawa cells and fertile endometrial organoid-derived epithelial cells significantly improved their adhesive capacity to trophoblast progenitor spheroids. miR-23b-3p overexpression in infertile endometrial organoid-derived epithelial cells did not improve adhesion. Among 10 miR-predicted gene targets examined, miR-23b-3p overexpression in Ishikawa cells significantly reduced the expression of MET, secreted frizzled-related protein 4 (SFRP4) and acyl-CoA dehydrogenase short/branched chain (ACADSB) compared to control. The reduction of SFRP4 after miR23b-3p overexpression was confirmed by immunoblotting in fertile organoid-derived epithelial cells. SFRP4 expression in fertile endometrium exhibited an inverse expression pattern compared to miR-23b-3p and was higher in the proliferative phase compared to the mid-secretory phase. Overall, miR-23b-3p is likely a critical regulator of endometrial epithelial adhesion and receptivity.