bluuebunny/crossref_metadata_2025_split huggingface dataset:
Yellow and Orange–Red Room‐Temperature Phosphorescence from Amorphous Nonaromatic Polymers
Authors: Deng Junwen , Bai Yunhao , Li Jingyun , Jiang Junyao , Zhao Chen , Xie Wendi , Guo Yidan , Liu Haiqi , Liu Deyu , Yu Linxuan , Wang Huiliang 
Published: July 2023

AbstractMany nontraditional luminogens (NTLs) without any large π‐conjugated structures are reported to exhibit room‐temperature phosphorescence (RTP). Unfortunately, the reported NTLs mostly emit blue or green RTP. Achieving more redshifted RTP from NTLs remains a great challenge. Herein, a series of nonaromatic polymers exhibiting yellow and orange–red RTP are reported. Poly(itaconic anhydride) (PITA) does not exhibit RTP, its hydrolyzed product poly(itaconic acid) (PITAc) exhibits weak yellow RTP, but the ionized product poly(sodium itaconate) (PITANa) can emit stronger and redshifted RTP. Moreover, the ionized copolymers poly(vinyl pyrrolidone‐co‐sodium itaconate) (PIVPNa) and poly(vinyl pyrrolidone‐co‐sodium maleate) (PMVPNa), the mixture of PITANa/poly(vinyl pyrrolidone) (PVP), and the full hydrolyzed product of poly(vinyl caprolactam‐co‐sodium itaconate) (PIVCNa) all exhibit strong orange–red RTP emissions at ≈600 nm. Structural characterizations and theoretical calculations prove that hydrogen bonding and ionic bonds lead to the rigidification of polymer chain conformations, and more importantly, both intra‐ and interchain nonaromatic electron donor–acceptor (nDA) structures and hence through‐space charge transfer are formed between carboxylate and lactam groups in proper conformations, which facilitates the occurrence and redshift of RTP in NTLs. This work provides a novel strategy to design NTLs with redshifted RTP and improves the understanding of the photoluminescence mechanism of NTLs.
Computational Modeling for Intelligent Surface Plasmon Resonance Sensor Design and Experimental Schemes for Real‐Time Plasmonic Biosensing: A Review
Authors: Das Chandreyee Manas , Yang Fan , Yang Zhenxu , Liu Xiaochen , Hoang Quang Thien , Xu Zhejun , Neermunda Shabana , Kong Kien Voon , Ho Ho‐Pui , Ju Lining Arnold , Xiong Jiaqing , Yong Ken‐Tye 
Published: July 2023

AbstractThe spectacular physical phenomenon of surface plasmon resonance (SPR) is the essence of present‐day plasmonic sensors. Meanwhile, the unique properties of the interaction between light and matter have been carved out into the development of modern‐day diagnostic biosensors. Plasmons, in simple terms, are oscillating free electrons in metallic nano‐structures triggered by an incoming electromagnetic (EM) wave. With the advantages of real‐time and label‐free bio‐sensing, plasmonic sensors are being utilized in multiple diverse areas of food technology, the bio‐medical diagnostic sector, and even the chemical industry. Although this review will be brief, readers can gain a comprehensive picture of the essential elements by taking a broader look into the exploration of SPR sensor design via simulated studies and representative experimental plasmonic schemes developed for bio‐sensing. In short, the various SPR sensing schemes that researchers have explored to realize enhanced SPR sensitivity are reviewed and summarized. Different experimental plasmonic sensors are also examined in which new SPR excitation schemes have been adopted. These "unconventional" designs, specifically those involving hybrid localized surface plasmon resonance (LSPR)‐SPR excitation, may inspire those in the plasmonic field.
The NLRP11 Protein Bridges the Histone Lysine Acetyltransferase KAT7 to Acetylate Vimentin in the Early Stage of Lung Adenocarcinoma
Authors: Yang Rui , Peng Weilin , Shi Shuai , Peng Xiong , Cai Qidong , Zhao Zhenyu , He Boxue , Tu Guangxu , Yin Wei , Chen Yichuan , Zhang Yuqian , Liu Fang , Wang Xiang , Xiao Desheng , Tao Yongguang 
Published: July 2023

AbstractAccumulation of vimentin is the core event in epithelial–mesenchymal transition (EMT). Post‐translational modifications have been widely reported to play crucial roles in imparting different properties and functions to vimentin. Here, a novel modification of vimentin, acetylated at Lys104 (vimentin‐K104Ac) is identified, which is stable in lung adenocarcinoma (LUAD) cells. Mechanistically, NACHT, LRR, and PYD domain‐containing protein 11 (NLRP11), a regulator of the inflammatory response, bind to vimentin and promote vimentin‐K104Ac expression, which is highly expressed in the early stages of LUAD and frequently appears in vimentin‐positive LUAD tissues. In addition, it is observed that an acetyltransferase, lysine acetyltransferase 7 (KAT7), which binds to NLRP11 and vimentin, directly mediates the acetylation of vimentin at Lys104 and that the cytoplasmic localization of KAT7 can be induced by NLRP11. Malignant promotion mediated by transfection with vimentin‐K104Q is noticeably greater than that mediated by transfection with vimentin‐WT. Further, suppressing the effects of NLRP11 and KAT7 on vimentin noticeably inhibited the malignant behavior of vimentin‐positive LUAD in vivo and in vitro. In summary, these findings have established a relationship between inflammation and EMT, which is reflected via KAT7‐mediated acetylation of vimentin at Lys104 dependent on NLRP11.
Inhibition of CDK1 Overcomes Oxaliplatin Resistance by Regulating ACSL4‐mediated Ferroptosis in Colorectal Cancer
Authors: Zeng Kaixuan , Li Weihao , Wang Yue , Zhang Zifei , Zhang Linjie , Zhang Weili , Xing Yue , Zhou Chi 
Published: July 2023

AbstractOxaliplatin is a widely used chemotherapy drug for patients with advanced colorectal cancer (CRC); however, frequent drug resistance limits its therapeutic efficacy in patients. Here, this work identifies cyclin‐dependent kinase 1 (CDK1) as a critical contributor to oxaliplatin resistance via in vitro and in vivo CRISPR/Cas9 screening. CDK1 is highly expressed in oxaliplatin‐resistant cells and tissues due to the loss of N6‐methyladenosine modification. Genetic and pharmacological blockade of CDK1 restore the susceptibility of CRC cells to oxaliplatin in vitro and in cell/patient‐derived xenograft models. Mechanistically, CDK1 directly binds to and phosphorylates Acyl‐CoA synthetase long‐chain family 4 (ACSL4) at S447, followed by recruitment of E3 ubiquitin ligase UBR5 and polyubiquitination of ACSL4 at K388, K498, and K690, which leads to ACSL4 protein degradation. Reduced ACSL4 subsequently blocks the biosynthesis of polyunsaturated fatty acid containing lipids, thereby inhibiting lipid peroxidation and ferroptosis, a unique iron‐dependent form of oxidative cell death. Moreover, treatment with a ferroptosis inhibitor nullifies the enhancement of CRC cell sensitivity to oxaliplatin by CDK1 blockade in vitro and in vivo. Collectively, the findings indicate that CDK1 confers oxaliplatin resistance to cells by suppressing ferroptosis. Therefore, administration of a CDK1 inhibitor may be an attractive strategy to treat patients with oxaliplatin‐resistant CRC.
Evolution from Bioinert to Bioresorbable: In Vivo Comparative Study of Additively Manufactured Metal Bone Scaffolds
Authors: Zhou Juncen , Georgas Elias , Su Yingchao , Zhou Jiayi , Kröger Nadja , Benn Felix , Kopp Alexander , Qin Yi‐Xian , Zhu Donghui 
Published: July 2023

AbstractAdditively manufactured scaffolds offer significant potential for treating bone defects, owing to their porous, customizable architecture and functionalization capabilities. Although various biomaterials have been investigated, metals – the most successful orthopedic material – have yet to yield satisfactory results. Conventional bio‐inert metals, such as titanium (Ti) and its alloys, are widely used for fixation devices and reconstructive implants, but their non‐bioresorbable nature and the mechanical property mismatch with human bones limit their application as porous scaffolds for bone regeneration. Advancements in additive manufacturing have facilitated the use of bioresorbable metals, including magnesium (Mg), zinc (Zn), and their alloys, as porous scaffolds via Laser Powder Bed Fusion (L‐PBF) technology. This in vivo study presents a comprehensive, side‐by‐side comparative analysis of the interactions between bone regeneration and additively manufactured bio‐inert/bioresorbable metal scaffolds, as well as their therapeutic outcomes. The research offers an in‐depth understanding of the metal scaffold‐assisted bone healing process, illustrating that Mg and Zn scaffolds contribute to the bone healing process in distinct ways, but ultimately deliver superior therapeutic outcomes compared to Ti scaffolds. These findings suggest that bioresorbable metal scaffolds hold considerable promise for the clinical treatment of bone defects in the near future.
Anisotropic Plasmonic Metasurfaces with Linear Polarization‐Dependent Focusings
Authors: Zhang Heyi , Zhang Runxuan , He Canhui , Li Changqing , Song Zhengyong 
Published: July 2023

AbstractAs a burgeoning approach to modulate electromagnetic waves, metasurfaces fascinate many researchers. However, it is a persistent problem to realize independent wavefront tailoring in different polarization states. In this work, anisotropic plasmonic metasurfaces are presented with linear polarization‐dependent focusings. The designed plasmonic meta‐atoms consist of cross‐shaped gold, silica spacer, and gold substrate. Phase modulation in different polarization channels is independently achieved by adjusting the dimensions of cross‐shaped gold in x‐ and y‐directions. Three metasurfaces are presented to verify linear polarization‐dependent focusings at 200 THz. First, a focusing metasurface is designed with focal lengths of 5.2 µm under x‐polarized incidence and 6.5 µm under y‐polarized incidence. Second, by applying convolution operation, the second metasurface exhibits different focusings with different deflection angles at opposite directions under orthogonally polarized incidences. Finally, a multi‐focal metasurface is demonstrated, which switches between dual‐ and quad‐focal points depending on polarization state. The work may provide a novel platform for near‐infrared integrated photonics.
Catalytic Photochemical Deracemization via Short‐Lived Intermediates
Authors: Großkopf Johannes , Bach Thorsten 
Published: July 2023

AbstractUpon irradiation in the presence of a suitable chiral catalyst, racemic compound mixtures can be converted into enantiomerically pure compounds with the same constitution. The process is called photochemical deracemization and involves the formation of short‐lived intermediates. By opening different reaction channels for the forward reaction to the intermediate and for the re‐constitution of the chiral molecule, the entropically disfavored process becomes feasible. Since the discovery of the first photochemical deracemization in 2018, the field has been growing rapidly. This review comprehensively covers the research performed in the area and discusses current developments. It is subdivided according to the mode of action and the respective substrate classes. The focus of this review is on the scope of the individual reactions and on a discussion of the mechanistic details underlying the presented reaction.
The development of a pilot ‘thinking about relationships prompt sheet’ within an alcohol and other drugs rehabilitation programme
Authors: Anderson Bella , Furlong Mark 
Published: July 2023

AbstractThis paper documents the development of a programme component within an alcohol and other drugs residential service. Designed to improve relational competence, this pilot component was designed to have multiple levels of function: from the specific, for example, stimulating residents to formulate and monitor relationally oriented goals, to the more pacific, for example, embedding relationally focused learning as an ongoing rehabilitative concern. Development of the component began with a literature review. After finalising a set of relationship types (friends, siblings, etc.), this review identified three domains: ‘values’, ‘knowledge’ and ‘skills’. To create an initial draft, these categories were populated by items selected from a multi‐stage inspection of the relevant literature. This draft was then reviewed by multiple stakeholder groups. Feedback from these consultations resulted in substantial modifications to the initial draft. In addition to the component having a broad‐spectrum interventive purpose, the authors propose that this component could play a role in (i) pre‐admission assessment and (ii) programme evaluation insofar as data concerning individual residents are aggregated and analysed.
Command filter‐based adaptive control of flexible‐joint manipulator with input saturation and output constraints
Authors: Shi Miao , Yu Jianjiang , Zhang Tianping 
Published: July 2023

AbstractThis paper focuses on the topic of adaptive neural tracking control for flexible‐joint manipulator systems with output restrictions and input saturation. With the aid of the error compensation mechanism, command filter‐based adaptive neural control is proposed for robotic systems driven by permanent magnet synchronous machine (PMSM). An auxiliary signal produced by the first‐order linear system designed by the property of unmodeled dynamics is used to erase the dynamical uncertainties. The input saturation of system is estimated by
‐function with mathematical transformation. Using barrier Lyapunov function (BLF), each component constraint of output is tackled. During the virtual control design phase, radial basis function neural networks (RBFNNs) may reliably assess the unknown nonlinear continuous function. All the variables in the closed‐loop system are proved to be semiglobally uniform ultimate bounded (SGUUB) by integrating all compensation signals into the overall Lyapunov function and using the defined compact set in the stability analysis of dynamic surface control (DSC). An applied example on robotic system is used to verify the effectiveness of the constructed design idea.
Engineering T cell receptor fusion proteins using nonviral CRISPR/Cas9 genome editing for cancer immunotherapy
Authors: Shu Runzhe , Hammett Maree , Evtimov Vera , Pupovac Aleta , Nguyen Nhu‐Y , Islam Rasa , Zhuang Junli , Lee Seyeong , Kang Tae‐hun , Lee Kyujun , Nisbet Ian , Hudson Peter , Lee Jae Young , Boyd Richard , Trounson Alan 
Published: July 2023

AbstractManufacture of chimeric antigen receptor (CAR)‐T cells usually involves the use of viral delivery systems to achieve high transgene expression. However, it can be costly and may result in random integration of the CAR into the genome, creating several disadvantages including variation in transgene expression, functional gene silencing and potential oncogenic transformation. Here, we optimized the method of nonviral, CRISPR/Cas9 genome editing using large donor DNA delivery, knocked‐in an anti‐tumor single chain variable fragment (scFv) into the N‐terminus of CD3ε and efficiently generated fusion protein (FP) T cells. These cells displayed FP integration within the TCR/CD3 complex, lower variability in gene expression compared to CAR‐T cells and good cell expansion after transfection. CD3ε FP T cells were predominantly CD8+ effector memory T cells, and exhibited anti‐tumor activity in vitro and in vivo. Dual targeting FP T cells were also generated through the incorporation of scFvs into other CD3 subunits and CD28. Compared to viral‐based methods, this method serves as an alternative and versatile way of generating T cells with tumor‐targeting receptors for cancer immunotherapy.
DreamWalk: Dynamic remapping and multiperspectivity for large‐scale redirected walking
Authors: Xiong Yuan , Chen Tong , Li Tianjing , Zhou Zhong 
Published: July 2023

SummaryRedirected walking (RDW) provides an immersive user experience in virtual reality applications. In RDW, the size of the physical play area is limited, which makes it challenging to design the virtual path in a larger virtual space. Mainstream RDW approaches rigidly manipulate gains to guide the user to follow predetermined rules. However, these methods may cause simulator sickness, boundary collision, and reset. Static mapping approaches warp the virtual path through expensive vertex replacement in the stage of model pre‐processing. They are restricted to narrow spaces with non‐looping pathways, partition walls, and planar surfaces. These methods fail to provide a smooth walking experience for large‐scale open scenes. To tackle these problems, we propose a novel approach that dynamically redirects the user to walk in a non‐linear virtual space. More specifically, we propose a Bezier‐curve‐based mapping algorithm to warp the virtual space dynamically and apply multiperspective fusion for visualization augmentation. We conduct comparable experiments to show its superiority over state‐of‐the‐art large‐scale redirected walking approaches on our self‐collected photogrammetry dataset.
Quinolinones Alkaloids with AChE Inhibitory Activity from Mangrove Endophytic Fungus Penicillium citrinum YX‐002
Authors: Liu Yayue , Xue Xinyi , Zhou Longjian , Yang Wencong , She Zhigang , Liao Qingnan , Feng Yunkai , Chen Xiaokun , Zhang Yi 
Published: July 2023

AbstractAcetylcholinesterase (AChE) inhibitory activity‐guided studies on the mangrove‐derived endophytic fungus Penicillium citrinum YX‐002 led to the isolation of nine secondary metabolites, including one new quinolinone derivative, quinolactone A (1), a pair of epimers quinolactacin C1 (2) and 3‐epi‐quinolactacin C1 (3), together with six known analogs (4–9). Their structures were elucidated based on extensive mass spectrometry (MS) and 1D/2D nuclear magnetic resonance (NMR) spectroscopic analyses, and compared with data in the literature. The absolute configurations of compounds 1–3 was determined by combination of electronic circular dichroism (ECD) calculations and X‐Ray single crystal diffraction technique using CuKα radiation. In bioassays, compounds 1, 4 and 7 showed moderate AChE inhibitory activities with IC50 values of 27.6, 19.4 and 11.2 μmol/L, respectively. The structure‐activity relationships (SARs) analysis suggested that the existence of carbonyl group on C‐3 and the oxygen atom on the five‐membered ring were beneficial to the activity. Molecular docking results showed that compound 7 had a lower affinity interaction energy (−9.3 kcal/mol) with stronger interactions with different sites in AChE activities, which explained its higher activities.
Development of an Optimized Method to Obtain a Limonene‐Rich Concentrate from the Discarded Lemon Peels
Authors: Balci‐Torun Ferhan , Toprakçı İrem , Deniz Nahide Gulşah , Ortaboy Sinem , Torun Mehmet , Şahin Selin 
Published: July 2023

AbstractIn this study, lemon peels were used as volatile component source. Automatic solvent extraction has been used for the recovery of limonene rich citrus volatile extract for the first time. The process parameters (amount of raw material, immersion time and washing time) were analyzed to optimize the process by means of Box‐Behnken design via response surface methodology. The optimum conditions were achieved by ~10 g fresh lemon peel, and ~15 min immersion time and ~13 min washing time. The difference between the actual (89.37 mg/g limonene) and predicted (90.85 mg/g limonene) results was satisfactory (<2 %). α‐Terpinene, β‐pinene, citral, ɣ‐terpinene and linalool were determined as other major volatiles in the peel extract. FT‐IR and1H‐ and13C‐NMR spectroscopies were applied to verify the identified volatile compounds.
Spontaneous tension pneumomediastinum with pneumothorax and subcutaneous emphysema as a complication of COVID‐19 disease
Authors: Aghajanzadeh Manouchehr , Alavi Foumani Ali , Tangestaninejad Azita , Haghighi Mohammad , Pourahmadi Yousha , Jafroudi Ehsan Hajipour , Mousazadeh Mahsa , Asli Rastin Hosseinzadeh 
Published: July 2023

Key Clinical MessageRecently spontaneous tension pneumomediastinum (STM), were reported as infrequent complications in coronavirus disease 2019 (COVID‐19) patients but pneumothorax (PT), and subcutaneous emphysema (SE) are more frequently seen in COVID‐19 patients. PT and SE may present after PTM in COVID‐19. The aim of this presentation is to show the complications of STM in an Iranian patients with COVID‐19 disease with PT and SE, who were hospitalized in Arya hospital, Rasht, Iran. For 3 months, we followed these patients and their condition was good. STM are uncommon complications in COVID‐19 patients and were reported frequently in male patients. Early diagnosis and treatment could save the patients as these complications are related to poor prognosis and prolonged hospitalization. Patients with mild COVID‐19 and mild pulmonary damage may have a favorable outcome.
Coexistence of ipsilateral acute‐on‐chronic subdural hematoma and acute extradural hematoma: A case report
Authors: Basit Jawad , Javed Saad , Shahzad Faizan , Yaqoob Eesha , Saeed Sajeel , Anand Ayush 
Published: July 2023

AbstractChronic subdural hematomas are typically observed in elderly patients receiving antithrombotic and/or anticoagulant therapy. In contrast, acute subdural and extradural hematomas are often observed in young people with traumatic brain injury. The coexistence of ipsilateral chronic subdural and extradural hematomas is rare. Depending on the Glasgow Coma Scale and neuroimaging findings, early surgical intervention is mandatory, as seen in our patient. Early surgical evacuation of a traumatic extradural and chronic subdural hematoma should be done. Also, antithrombotic drug use can lead to chronic subdural hematoma.
Antimalarial Agents Derived from Metal‐Amodiaquine Complexes with Activity in Multiple Stages of the Plasmodium Life Cycle
Authors: Colina‐Vegas Legna , da Cruz B. Silva Mariana , de Souza Pereira Caroline , Isis Barros Ariane , Araújo Nobrega Joaquim , Navarro Maribel , Rottmann Matthias , D'Alessandro Sarah , Basilico Nicoletta , Azevedo Batista Alzir , Moreira Diogo R. M. 
Published: July 2023

AbstractMalaria is the one of the deadliest infectious diseases worldwide. Chemically, quinolines are excellent ligands for metal coordination and are deployed as drugs for malaria treatment. There is a growing body of evidence indicating that metal complexes can be conjugated with antimalarial quinolines to be used as chemical tools to overcome the disadvantages of quinolines, improving their bioactive speciation, cellular distribution, and subsequently broadening the spectrum of activity to multiple stages of the complex Plasmodium life cycle. In this study, four novel complexes of ruthenium(II)‐ and gold(I)‐containing amodiaquine (AQ) were synthesized, and a careful chemical characterization revealed the precise coordination site of AQ to the metals. Their speciation in solution was investigated, demonstrating the stability of the quinoline‐metal bond. RuII‐ and AuI‐AQ complexes were demonstrated to be potent and efficacious in inhibiting parasite growth in multiple stages of the Plasmodium life cycle as assayed in vitro and in vivo. These properties could be attributed to the ability of the metal‐AQ complexes to reproduce the suppression of heme detoxification induced by AQ, while also inhibiting other processes in the parasite life cycle; this can be attributed to the action of the metallic species. Altogether, these findings indicate that metal coordination with antimalarial quinolines is a potential chemical tool for drug design and discovery in malaria and other infectious diseases susceptible to quinoline treatment.
On the correlation analysis of stocks with zero returns
Authors: Raïssi Hamdi 
Published: July 2023

AbstractThe purpose of this article is to study serial correlations, allowing for unconditional heteroscedasticity and time‐varying probabilities of zero financial returns. Depending on the set‐up, we investigate how the standard autocorrelations can be accommodated to deliver an accurate representation of the serial correlations of stock price changes. We shed light on the properties of the different serial correlations measures by means of Monte Carlo experiments. Theoretical results are also illustrated on shares from the Chilean stock market and Facebook stock intraday data.