bluuebunny/crossref_metadata_2025_split huggingface dataset:
A multi-center, randomized, 12-month, parallel-group, feasibility study to assess the acceptability and preliminary impact of family navigation plus usual care versus usual care on attrition in managing pediatric obesity: a study protocol
Authors: Ball Geoff D. C. , O’Neill Marcus G. , Noor Rafat , Alberga Angela , Azar Rima , Buchholz Annick , Enright Michelle , Geller Josie , Ho Josephine , Holt Nicholas L. , Lebel Tracy , Rosychuk Rhonda J. , Tarride Jean-Eric , Zenlea Ian 
Published: January 2023

Abstract
Background
Pediatric obesity management can be successful, but some families discontinue care prematurely (i.e., attrition), limiting treatment impact. Attrition is often a consequence of barriers and constraints that limit families’ access to obesity management. Family Navigation (FN) can improve access, satisfaction with care, and treatment outcomes in diverse areas of healthcare. To help our team prepare for a future effectiveness trial, the objectives of our randomized feasibility study are to (i) explore children’s and caregivers’ acceptability of FN and (ii) examine attrition, measures of study rigor and conduct, and responses to FN + Usual Care vs Usual Care by collecting clinical, health services, and health economic data.

Methods
In our 2.5-year study, 108 6–17-year-olds with obesity and their caregivers will be randomized (1:1) to FN + Usual Care or Usual Care after they enroll in obesity management clinics in Calgary and Mississauga, Canada. Our Stakeholder Steering Committee and research team will use Experience-Based Co-Design to design and refine our FN intervention to reduce families’ barriers to care, maximizing the intervention dose families receive. FN will be delivered by a navigator at each site who will use logistical and relational strategies to enhance access to care, supplementing obesity management. Usual Care will be offered similarly at both clinics, adhering to expert guidelines. At enrollment, families will complete a multidisciplinary assessment, then meet regularly with a multidisciplinary team of clinicians for obesity management. Over 12 months, both FN and Usual Care will be delivered virtually and/or in-person, pandemic permitting. Data will be collected at 0, 3, 6, and 12 months post-baseline. We will explore child and caregiver perceptions of FN acceptability as well as evaluate attrition, recruitment, enrolment, randomization, and protocol integrity against pre-set success thresholds. Data on clinical, health services, and health economic outcomes will be collected using established protocols. Qualitative data analysis will apply thematic analysis; quantitative data analysis will be descriptive.

Discussion
Our trial will assess the feasibility of FN to address attrition in managing pediatric obesity. Study data will inform a future effectiveness trial, which will be designed to test whether FN reduces attrition.

Trial registration
This trial was registered prospectively at ClinicalTrials.gov (#NCT05403658; first posted: June 3, 2022).
Adaptation and validation of the Adult Dispositional Hope Scale in the Ecuadorian context
Authors: Vinueza-Solórzano Andrea M. , Campoverde Ronald Enrique , Portalanza-Chavarría Cecilia Alexandra , de Freitas Clarissa P. P. , Hutz Claudio Simon , Vazquez Ana Claudia Souza 
Published: January 2023

AbstractThis study aimed to evidence the validity and reliability of the Ecuadorian version of the Adult Dispositional Hope Scale, one of the most studied concepts of positive psychology. The adaptation process included translation and semantic and idiomatic validation. For content validation, an expert review and focus group were conducted. The questionnaire was applied to 2423 workers in Ecuador with a mean age of 37 years (SD = 9.04), and 65.6% were women. A confirmatory factor analysis was conducted to assess the validity of the scale’s dimensionality. The reliability and convergent and discriminant validity were also evaluated. In order to investigate the best solution for an Ecuadorian version of the Adult Dispositional Hope Scale, four structural models were assessed. The unidimensional solution was the most adequate structure for the scale. The internal consistency of the scale was adequate. The Adult Dispositional Hope Scale (ADHS) was developed to assess this positive psychological state and has been the most used tool in many contexts. To our knowledge, this study is the first to adapt the Adult Dispositional Hope Scale into the Ecuadorian context and evaluate its validity. The findings support its reliability, factorial, and construct validity in the Ecuadorian context. Furthermore, the results show that dispositional hope acts as a protective factor, promoting work engagement and preventing burnout.
Evaluation of P-glycoprotein-targeting circulating microRNAs as peripheral biomarkers for medically intractable epilepsy
Authors: Xie Yangmei , Shao Yiye , Gong Xue , Wang Ming , Chen Yinghui 
Published: January 2023

AbstractBackgroundEarly diagnosis of medically intractable epilepsy is challenging in clinical work. P-glycoprotein (P-gp) is one of the most important multidrug efflux transporters, which has been demonstrated to contribute to the drug resistance of intractable epilepsy. The present study was aimed to explore the diagnostic value of microRNAs (miRNAs) targeting P-gp for medically intractable epilepsy.MethodsThirty-six patients with intractable epilepsy and 36 epilepsy patients responsive to anti-epilepsy drugs, who visited Jinshan Hospital of Fudan University from September 2014 to September 2016, were enrolled in this study. Clinical information of the patients was obtained by retrospectively reviewing medical records. MiRNAs with differential serum expression between the two groups of patients were detected by microarray assay. Meanwhile, miRNAs that were confirmed to regulate P-gp in vitro by western blot were selected for further validation. In the validation phase, reverse transcription quantitative PCR (RT-qPCR) was conducted to confirm the differential expression of the candidate miRNAs in the epilepsy cohorts. Receiver operating characteristic (ROC) curve analysis was carried out to evaluate the diagnostic value of the miRNAs for intractable epilepsy.ResultsThree miRNAs including miR-6514-3p, miR-6076-5p, and miR-6855-3p were identified to be candidate miRNAs by microarray assay. The results of western blotting validated that miR-146a-5p and miR-138-5p could regulate P-gp expression in vitro, so they were included in the candidate miRNAs for further validation. In the validation phase, the results of RT-qPCR indicated that compared with drug-responsive patients, the patients with intractable epilepsy showed decreased level of miR-138-5p and increased level of miR-146a-5p. The results of ROC curve analysis indicated that miR-138-5p (AUC = 0.877) and miR-146a-5p (AUC = 0.866) had high diagnostic value for intractable epilepsy. In addition, the miR-panel composed of miR-138-5p and miR-146a-5p showed higher diagnostic value (AUC = 0.926) than the miRNAs selected by microarray assay.ConclusionsOur results indicated that the dysregulated miR-138-5p and miR-146a-5p which target P-gp expression have high potential as peripheral biomarkers for medically intractable epilepsy.
Short-Term Surgical Mission in Sub-Saharan Country, Experience of a Breast-Dedicated Team: Reviewing the Past and Stepping Toward the Last Mission
Authors: Djedjo Luís , Martins Maria do Céu Oliveira , Bicho Luís , Andrade David , Sidiropoulou Zacharoula 
Published: January 2023

PURPOSE The present article aims to present the data of a Breast Cancer Team Short-Term Surgical Mission in Guinea-Bissau in the setting of the National Bissau Hospital, Hospital Nacional Simão Mendes, level A referral health structure. PATIENTS AND METHODS Patients with breast disease have been presented to our team for in loco consultation during the total of three missions in 1 year. We have observed a total of 97 female patients with age ranging from 12 to 70 years. We performed 21 excisional biopsies, five radical surgeries, and 28 needle biopsies. RESULTS There have been diagnosed 19 invasive breast cancer cases in stage IV, and in seven patients, the biopsy resulted in malignancy. On the recall consultation of the needle biopsied patients, just two returned and accepted the proposed treatment. Major issue has been the lack of trained pathology technicians for adequate sampling conditioning, a fact that led to a poor quality of 18 samples. CONCLUSION Access to surgical care is disparate across the world, and short-term surgical missions are often call-in action to deliver not only patient care but also local staff training. Complex disease management, such as cancer, may create several problems being conditioned by the lack of basic resources required. In Guinea-Bissau, a poor country with very few inhabitants, the need to implement an anticancer national strategy is urgent but seems feasible. Any action should prioritize local team training and enhance specialization. No external intervention can provide any long-term benefit for patients if they are detached from local health workers.
Clinicopathologic and Molecular Analysis of Normal Karyotype Therapy-Related and De Novo Acute Myeloid Leukemia: A Multi-Institutional Study by the Bone Marrow Pathology Group
Authors: Cantu Miguel D. , Kanagal-Shamanna Rashmi , Wang Sa A. , Kadia Tapan , Bueso-Ramos Carlos E. , Patel Sanjay S. , Geyer Julia T. , Tam Wayne , Madanat Yazan , Li Peng , George Tracy I. , Nichols Meredith M. , Rogers Heesun J. , Liu Yen-Chun , Aggarwal Nidhi , Kurzer Jason H. , Maracaja Danielle L.V. , Hsi Eric D. , Zaiem Feras , Babu Daniel , Foucar Kathryn , Laczko Dorottya , Bagg Adam , Orazi Attilio , Arber Daniel A. , Hasserjian Robert P. , Weinberg Olga K. 
Published: January 2023

PURPOSE Therapy-related acute myeloid leukemias (t-AML) are a heterogenous group of aggressive neoplasms that arise following exposure to cytotoxic chemotherapy and/or ionizing radiation. Many therapy-related myeloid neoplasms (t-MN) are associated with distinct chromosomal aberrations and/or TP53 alterations, but little is known about the clinicopathologic and molecular features of normal karyotype t-AML (NK-t-AML) and whether this t-MN subtype is distinctly different from NK de novo AML (NK-dn-AML). METHODS This multi-institutional study by the Bone Marrow Pathology Group retrospectively evaluated clinicopathologic and molecular characteristics of 335 patients with NK-AML, comprising 105 t-AML and 230 dn-AML cases. RESULTS Patients with t-AML compared with dn-AML exhibit significantly shorter overall survival (OS; median months: 17.6 v 44.2; P < .0001) and relapse-free survival (RFS; median months: 9.1 v 19.2; P = .0018). Frequency of NPM1, FLT3, KRAS, and GATA2 mutations were significantly different in NK-t-AML compared with NK-dn-AML ( NPM1 35% v 49%; P = .0493; FLT3 23% v 36%; P = 0494; KRAS 12% v 5%; P = .0465; GATA2 9% v 2% P = .0105), while TP53 mutations were rare. Patients with t-AML more often stratified into intermediate or adverse 2017 ELN genetic risk groups. Favorable ELN risk predicted favorable OS (hazard ratio [HR], 0.4056; 95% CI, 0 to 0.866; P = .020) and RFS (HR, 0.355; 95% CI, 0 to 0.746; P = .006). Among all patients with NK-AML, stem-cell transplant and favorable ELN risk both significantly affected RFS, while therapy-relatedness and age had a borderline significant impact on OS (HR, 1.355; 95% CI, 0.975 to 1.882; P = .070). CONCLUSION To our knowledge, this is the largest study to date to comprehensively evaluate NK-t-AML and provides a framework that may inform our understanding of NK-t-AML disease biology and could potentially help guide therapeutic management and improved disease classification in t-MNs that lack cytogenetic aberrations.
Survival Outcomes of Patients With Tropomyosin Receptor Kinase Fusion-Positive Cancer Receiving Larotrectinib Versus Standard of Care: A Matching-Adjusted Indirect Comparison Using Real-World Data
Authors: Bokemeyer Carsten , Paracha Noman , Lassen Ulrik , Italiano Antoine , Sullivan Sean D. , Marian Marisca , Brega Nicoletta , Garcia-Foncillas Jesus 
Published: January 2023

PURPOSE Larotrectinib, a highly specific tropomyosin receptor kinase (TRK) inhibitor, previously demonstrated high response rates in single-arm trials of patients with TRK fusion-positive cancer, but there are limited data on comparative effectiveness against standard-of-care (SoC) regimens used in routine health care practice, before widespread adoption of TRK inhibitors as SoC for TRK fusion-positive cancers. Matching-adjusted indirect comparison, a validated methodology that balances population characteristics to facilitate cross-trial comparisons, was used to compare the overall survival (OS) of larotrectinib versus non–TRK-inhibitor SoC. MATERIALS AND METHODS Individual patient data from three larotrectinib trials (ClinicalTrials.gov identifiers: NCT02122913 , NCT02637687 , and NCT02576431 ) were compared with published aggregate real-world data from patients with locally advanced/metastatic TRK fusion-positive cancer identified in the Flatiron Health/Foundation Medicine database. OS was defined as the time from advanced/metastatic disease diagnosis to death. After matching population characteristics, the analyses included (1) a log-rank test of equality to test whether the two groups were similar before larotrectinib initiation; and (2) estimation of treatment effect of larotrectinib versus non–TRK-inhibitor SoC. These analyses are limited to prognostic variables available in real-world data. RESULTS Eighty-five larotrectinib patients and 28 non-TRK-inhibitor SoC patients were included in the analyses. After matching, log-rank testing showed no difference in baseline characteristics between the two groups ( P = .31). After matching, larotrectinib was associated with a 78% lower risk of death, compared with non–TRK-inhibitor SoC (adjusted hazard ratio, 0.22 [95% CI, 0.09 to 0.52]; P = .001); median OS was 39.7 months (95% CI: 16.4, NE [not estimable]) for larotrectinib and 10.2 months (95% CI: 7.2, 14.1) for SoC. CONCLUSION Matching-adjusted indirect comparison analyses suggest longer OS with larotrectinib, compared with non–TRK-inhibitor SoC, in adult patients with TRK fusion-positive cancer.
Fibronectin and JMJD6 Signature in Circulating Placental Extracellular Vesicles for the Detection of Preeclampsia
Authors: Alahari Sruthi , Ausman Jonathan , Porter Tyler , Park Chanho , Pettersson Ante B V , Klemetti Miira M , Zhang Jianhong , Post Martin , Caniggia Isabella 
Published: January 2023

AbstractPreeclampsia (PE) is a major obstetric complication that is challenging to predict. Currently, there are limited tools to assess placental health/function in crucial gestational periods for diagnosis and early prediction. The glycoprotein fibronectin (FN) is augmented in PE placentae, and associated with reduced activity of JMJD6, an oxygen sensor that regulates placental FN processing. Evidence implicates placenta-derived small extracellular vesicles (sEVs) in the pathogenesis of pregnancy-associated disorders. Here, we examined the utility of FN and JMJD6 in placental sEVs as putative markers for early- and late-onset PE (E-PE and L-PE). Maternal plasma was obtained from venous blood collected longitudinally during pregnancy (10-14, 16-22, and 26-32 weeks of gestation and at delivery) in normotensive term control, preterm control, L-PE, E-PE, and gestational hypertensive individuals. Placenta-derived sEVs were isolated and their FN and JMJD6 content and JMJD6 activity were measured. In women that went on to develop preeclampsia, FN content of circulating placental sEVs was significantly elevated as early as 10 to 14 weeks of gestation and remained augmented until the time of delivery. This was accompanied by a depletion in JMJD6 content. Multivariate receiver operating characteristic analysis revealed high predictive power for FN and JMJD6 as early markers of E-PE and L-PE. In vitro, hypoxia or JMJD6 loss promoted FN accumulation in sEVs that was reverted on restoring cellular iron balance with the natural compound, Hinokitiol. Elevated FN, along with diminished JMJD6 in circulating placental sEVs, serves as an early molecular signature for the detection of different hypertensive disorders of pregnancy and their severity.
The Effects of Global Alignment and Proportionality Scores on Postoperative Outcomes After Adult Spinal Deformity Correction
Authors: Passias Peter G. , Krol Oscar , Owusu-Sarpong Stephane , Tretiakov Peter , Passfall Lara , Kummer Nicholas , Ani Fares , Imbo Bailey , Joujon-Roche Rachel , Williamson Tyler K. , Sagoo Navraj S. , Vira Shaleen , Schoenfeld Andrew , De la Garza Ramos Rafael , Janjua Muhammad Burhan , Sciubba Daniel , Diebo Bassel G. , Paulino Carl , Smith Justin , Lafage Renaud , Lafage Virginie 
Published: January 2023

BACKGROUND:
Recent studies have suggested achieving global alignment and proportionality (GAP) alignment may influence mechanical complications after adult spinal deformity (ASD) surgery.

OBJECTIVE:
To investigate the association between the GAP score and mechanical complications after ASD surgery.

METHODS:
Patients with ASD with at least 5-level fusion to pelvis and minimum 2-year data were included. Multivariate analysis was used to find an association between proportioned (P), GAP-moderately disproportioned, and severely disproportioned (GAP-SD) states and mechanical complications (inclusive of proximal junctional kyphosis [PJK], proximal junctional failure [PJF], and implant-related complications [IC]). Severe sagittal deformity was defined by a “++” in the Scoliosis Research Society (SRS)-Schwab criteria for sagittal vertebral axis or pelvic incidence and lumbar lordosis.

RESULTS:
Two hundred ninety patients with ASD were included. Controlling for age, Charlson comorbidity index, invasiveness and baseline deformity, and multivariate analysis showed no association of GAP-moderately disproportioned patients with proximal junctional kyphosis, PJF, or IC, while GAP-SD patients showed association with IC (odds ratio [OR]: 1.7, [1.1-3.3]; P = .043). Aligning in GAP-relative pelvic version led to lower likelihood of all 3 mechanical complications (all P < .04). In patients with severe sagittal deformity, GAP-SD was predictive of IC (OR: 2.1, [1.1-4.7]; P = .047), and in patients 70 years and older, GAP-SD was also predictive of PJF development (OR: 2.5, [1.1-14.9]; P = .045), while improving in GAP led to lower likelihood of PJF (OR: 0.2, [0.02-0.8]; P = .023).

CONCLUSION:
Severely disproportioned in GAP is associated with development of any IC and junctional failure specifically in older patients and those with severe baseline deformity. Therefore, incorporation of patient-specific factors into realignment goals may better strengthen the utility of this novel tool.
Aspects of demography and palaeopathology among the Hellenistic Abderetes in Thrace, Greece
Authors: Agelarakis Anagnostis 
Published: January 2023

Η εργασία αυτή παρουσιάζει αποτελέσματα φυσικής ανθρωπολογικής έρευνας οστεολογικού υλικού των αρχαίων Αβδήρων, χρονολογούμενο στην Ελληνιστική εποχή. Η καλή διατήρηση ενός σκελετικού δείγματος 48 ατόμων, αποτελούμενο από τα δύο γένη και από διαφορετικές ηλικίες, έδωσε τη δυνατότητα να πραγματοποιηθούν λεπτομερείς εργαστηριακές αναλύσεις σκελετικής βιολογίας, παλαιοπαθολογίας, και αρχαιομετρίας. Τα επιστημονικά δεδομένα αυτής της ΄έρευνας διαφωτίζουν πολλές πλευρές του δημογραφικού τομέα, του παλαιοπαθολογικού συνόλου, και των ιδιαιτεροτήτων των σκελετo-μυικών αναγλύφων μεταξύ ανδρών και γυναικών αυτής της εποχής στα Άβδηρα, δίνοντας έτσι την δυνατότητα να πραγματοποιηθούν ακριβέστερες διαχρονικές συγκρίσεις μεταξύ των πληθυσμών αυτού του ΄χώρου από την Αρχαϊκή έως και τη Μεταβυζαντινή περίοδο.
The hoard Αρκαλοχώρι–Αστρίτσι 1936 (IGCH 154)
Authors: Trifiró M. D. 
Published: January 2023

Il tesoretto Αρκαλοχώρι–Αστρίτσι 1936 (IGCH 154). Il tesoretto IGCH 154, rinvenuto a Creta (località Astritsi), consta di emissioni argentee provenienti dalle città cretesi e da Cirene, Corinto e colonie, Argo, Tebe ed Egina. Sono state studiate solo le emissioni non–cretesi che ammontano a cinquantacinque monete d’argento a cui vanno aggiunti altri sei esemplari provenienti da Cirene. Questi ultimi ufficialmente appartengono ad un tesoretto rinvenuto nel 1935 a Hierapytna (IGCH 318), ma molto probabilmente fannoparte del nostro ripostiglio, e sono attualmente conservati insieme ad esso presso il Museo Numismatico di Atene.
Unitamente al catalogo numismatico si è fornito un breve commento relativo alle singole emissioni monetali, nel tentativo di contestualizzare le serie e di chiarirne la cronologia assoluta e relativa. Particolare attenzione è stata riservata alla monetazionecirenea nel tentativo di motivarne la presenza nell’isola di Creta, alla luce dei rapporti economici e commerciali testimoniatici dalle scarse fonti storiche. Per tali serie si èsostenuta una cronologia «bassa» (300/290–280 a.C.) e si è proposto di identificarne lo standard ponderale con la fase intermedia del peso tolemaico adottato dal 310 a.C., probabilmente in concomitanza con un cambiamento della ratio tra oro e argento.
I «pegasi» provengono sia da Corinto che dalle sue colonie (Anactorion, Amphilochian Argos, Thyrrheion) e presentano simboli e monogrammi differenti, ma cronologicamente appartengono tutti al V periodo Ravel (387–306 a.C.).Delle emissioni argive, scarsamente studiate, si è presentata la classificazione e si è proposta una cronologia molto ampia, dovendo necessariamente appartenere al periodo precedente l’ingresso della città nella Lega Achea.
Improving Dispute Resolution in Two-Sided Platforms: The Case of Review Blackmail
Authors: Papanastasiou Yiangos , Yang S. Alex , Zhang Angela Huyue 
Published: January 2023

We study the relative merits of different dispute resolution mechanisms in two-sided platforms in the context of disputes involving malicious reviews and blackmail. We develop a game-theoretic model of the strategic interactions between a seller and a (potentially malicious) consumer. In our model, the seller takes into account the impact of consumer reviews on his future earnings; recognizing this, a malicious consumer may attempt to blackmail the seller by purchasing the product, posting a negative review, and demanding ransom to remove it. Without a dispute resolution mechanism in place, the presence of malicious consumers in the market can lead to a significant decrease in seller profit, especially in settings characterized by high uncertainty about product quality. The introduction of a standard centralized dispute resolution mechanism (whereby the seller can report allegedly malicious reviews to the host platform, which then judges whether to remove the review) can restore efficiency to some extent but requires the platform’s judgments to be both very quick and highly accurate. We demonstrate that a more decentralized mechanism (whereby the firm is allowed to remove reviews without consulting the platform, subject to ex post penalties for wrongdoing) can be much more effective, while simultaneously alleviating—almost entirely—the need for the platform’s judgments to be quick. Our results suggest that decentralization, when implemented correctly, may represent a more efficient approach to dispute resolution. This paper was accepted by Victor Martínez-de-Albéniz, operations management. Funding: S. A. Yang and A. H. Zhang acknowledge the support of the Hong Kong General Research Fund [Grant “Decentralizing Platform Governance: Innovations from China; Project 17614921]. Supplemental Material: The online appendices are available at https://doi.org/10.1287/mnsc.2022.4655 .