bluuebunny/crossref_metadata_2025_split huggingface dataset:
Explore the mechanisms by which prenatal stress can lead to the emergence of neurodevelopmental and psychiatric disorders among children
Authors: Downes N. 
Published: August 2023

IntroductionMaternal stress experienced during pregnancy has potential lasting consequences on child development. One mechanism that can explain certain links between the activity of the maternal stress axis during pregnancy and the developmental trajectory of children is the maternal hypothalamic pituitary-adrenal (HPA) axis. Nevertheless, further exploration is needed as there are methodological limits in the existing literature, such as the lack of longitudinal data.ObjectivesTo fill this gap, this DEVSTRESS research project was created with the aim of increasing our understanding of the mechanisms linking prenatal maternal stress to child development using longitudinal data from the EDEN cohort study.MethodsIn this sample, various bio-psycho-social data were collected: (1) maternal stress was measured during pregnancy via questionnaires assessing childhood adversity, major life events, work-related stress, anxiety, and depressive symptoms; (2) children’s emotional and behavioural problems were reported at 3, 5, 8 and 11 years, and cognitive development was assessed by psychologists at 5 years of age; (3) maternal and child hair samples provided data on the level of cortisol in the hair, which were used as a biological marker of stress and were collected at birth for both mother and child, as well as 1, 3, and 5 years after birth from children.ResultsVarious statistical analyses have been conducted using this data to explore the longitudinal links between self-reported maternal prenatal stress and child outcomes.ConclusionsThis research project will be concluded in 2023, thus findings from the overall DEVSTRESS project and practical recommendations will be provided.Disclosure of InterestNone Declared
The Translation and Adaptation Of The Child Behaviour Checklist (CBCL) To Azerbaijan Culture
Authors: Osmanli N. , Ergene T. , Ozer A. 
Published: August 2023

IntroductionThe lack of valid and reliable screening tools is the one of the significant barriers to the extension of studies in child and adolescent mental health in Azerbaijan culture.ObjectivesThe aim of this study is to adapt the Child Behavior Checklist (CBCL 6-18) to Azerbaijan culture.MethodsStudy group of the research is consist of 1232 (630 female, 599 male) children and adolescents between the ages of 6-17 studying in classes 1 to 11 in Azerbaijan.The ability to explain the data obtained from Azerbaijani Version of CBCL by theoretical model was examined by confirmatory factor analysis (CFA).ResultsThe RMSEA index was calculated as .09 for the one-dimensional alternative model and Comparative Fit Index as .93 for CBCL Azerbaijani Version. It was concluded that the alternative one-dimensional model, where a series of indexes were evaluated together, has an acceptable fit.Internal consistency coefficients were calculated as .94 for Total Problems, .87 for Internalizationand .87 for Externatilazation. The internal consistency coefficients for the empirically based problem subtests varied between .62 and .86.Correlations with total score of total syndrome subtests of the checklist were calculated for female and male students and 6-11/12-17 ages, and a positive and significant correlation was found for female and male students and 6-11/12-17 age groups (p <.05). The correlations between the Total Problem and all syndrome subtests ranged from .68 to .88 for boys and .67 to .88 for girls. Furthermore, a strong correlation (r> .70) between Anxiety/Depression, Social Withdrawn/Depression and Internalizing Problems and between Aggressive Behavior, Delinquent Behaviour problem subtests and Externalizing Problems, was detected.It was found that Externalizing Problems and Aggressive Behavior subtests of boys has a significantly higher average than girls (p<.05).It was concluded that the scores of Social Withdrawn/Depression and Internalizing Problems of girls and Social Problems and Thought Problems of boys increases, and Social Withdrawn/Depression and Internalizing Problems scores of boys decreases as the age increases.ConclusionsConsidering that a row of indexes is evaluated together in examining model fit, it can be said that the model consisting of eight factors has an acceptable fit.Disclosure of InterestNone Declared
Clinician-Administered PTSD Scale for DSM-5,child and adolescent version: A transcultural validation
Authors: Kouki N. , Bourgou S. , Rezgui H. , Naffeti A. , Hamdoun M. , Belhadj A. 
Published: August 2023

IntroductionPosttraumatic stress disorder in the paediatric population has clinical features. The Clinician-Administered PTSD Scale for DSM-5,child and adolescent version (CAPS-CA-5) is the gold standard for the positive diagnosis.ObjectivesThe objectives of our work were to translate the CAPS-CA-5 into Tunisian dialectal Arabic and to validate it in our Tunisian sociocultural context.MethodsThis is a descriptive cross-sectional study conducted in the child psychiatry department of Mongi Slim Hospital and the forensic medicine department of Charles-Nicolle Hospital (Tunisia), among children older than seven years who were exposed to a potentially traumatic event at least one month before. We validated the tool through translation, content, construct validity and reliability. The statistical processing for this data was carried out using SPSS 26 software.ResultsWe conducted our study with 150 patients. The validation was made on 146 records after the exclusion of 4 incompleted assessments.We initially translated the CAPS-CA-5 into Tunisian dialect. We validated the content through pre-test and scientific committee evaluation.Afterwards, we validated the construction. We calculated the Bartlett’s sphericity test (p<0.001) .The KMO index that was 0.766.Concerning the reliability study, we found a Cronbach’s alpha coefficient equal to 0.92. We studied also the inter-raters reliability; we found an intra-class coefficient between 0.8 and 1ConclusionsWe validated the first Tunisian diagnostic tool for PTSD in children according to the DSM-5 criteria with satisfactory psychometric qualities.Disclosure of InterestNone Declared
Analysis of the factors that influence caregiver burden in adolescents with dual diagnosis
Authors: Susana Perez S. , Martin-Herrero I. 
Published: August 2023

IntroductionSerious mental illness in adolescence that not only has a significant impact on the patient but also on other contexts such as their family. Caregivers assume almost all of the care. This responsibility exposes caregivers to intense overload with negative consequences.ObjectivesTo evaluate and quantify the overload of the primary caregiver in children and adolescents with severe mental disorders.MethodsA prospective study was designed using structured interviews in caregivers of patients between 11 and 18 years of age with severe mental disorders and substance use who were evaluated in the psychiatric emergency service for 2 months. The Zarit Caregiver Burden Scale was used for quantitative assessment. Diagnosis, main caregiver, socio-health resources were recorded.ResultsOf a total of 35 patients with serious mental illness between 11 and 16 years of age, the following was observed: intense caregiver burden in 42.2% of cases, moderate in 21%. Being the main caregiver the mother. 27.5% had adequate use of socio-health resources, while 42.7% had not requested them. The greatest need detected was economic and rehabilitation.ConclusionsSerious mental disorder present since adolescence leads families to significant destabilization of the family nucleus and comorbidity of psychiatric disorders in caregivers. Good orientation and evaluation of individual cases are necessary to guide families about the resources available in the social and health network, thus avoiding a high overload of caregivers and improving the quality of life of families.Disclosure of InterestNone Declared
Differential diagnosis of psychosis and dissociative disorder: a case report
Authors: Arroyo Sánchez E. , Setién Preciados P. 
Published: August 2023

IntroductionPsychosis and dissociative disorders are both described in the DSM-5 as different diagnostic categories. However, a high comorbidity of these diagnoses has been observed in different studies, perhaps due to the overlapping of symptoms between them.ObjectivesA systematic review about overlapping symptoms in psychotic spectrum and dissociative disordersMethodsPresentation of the case of a patient and review of the existing literature on the differential diagnosis between dissociative disorder and other psychotic spectrum disorders.ResultsBoth similarities and differences have been found between both diagnoses. Patients with dissociative disorder experienced more dissociative and positive symptoms while those on the psychotic spectrum experienced more negative symptoms. The literature reflects that the two entities overlap on many of their diagnostic symptoms. On some occasions, more dissociation has been detected in patients diagnosed with the psychotic spectrum than those with a diagnosis of dissociative disorder.ConclusionsDespite the fact of being different diagnostic entities, the literature does not reflect clear boundaries between psychosis spectrum symptoms and dissociative disorder.Disclosure of InterestNone Declared
Psychotropic drugs and the environment: a comprehensive analysis of surface water concentrations and associated risks
Authors: Luykx J. 
Published: August 2023

IntroductionFor most countries it is currently unknown to what degree concentrations of psychotropic drugs in surface water exceed environmental threshold concentrations (ETCs) [MOU1] for ecosystems and what risk mitigation could be applied. ETCs are defined as per-compound threshold concentrations above which detrimental effects on reproduction, growth, and mortality of aquatic organisms cannot be excludeObjectivesTo quantify levels of antidepressants, antipsychotics, mood stabilizers, and benzodiazepines in surface water, investigate their sources and assess whether these levels exceed ETCs.Methods: DesignCross-sectional analysis of measured and modeled data. Environmental levels were compared to ETCs to evaluate their risks for the aquatic environment. Finally, sources of psychotropic drugs were investigated.SettingAll available Dutch water monitoring data from all regional and national monitoring campaigns of 2019, the last year before the COVID-19 pandemic.ExposuresConcentrations of aripiprazole, carbamazepine and its metabolites, clozapine, diazepam, (es)citalopram, fluoxetine, haloperidol, nortriptyline, olanzapine, oxazepam, temazepam, quetiapine, sertraline, valproic acid, and venlafaxine.Main outcomes and measuresThe main outcomes were measured and modeled concentrations of the aforementioned agents in surface water. As a secondary outcome, where possible, average risk quotients (RQs) were calculated by dividing the measured or modeled concentrations by the ETC. An RQ > 1 was interpreted as a risk to the environment.ResultsPsychotropic drug samples (n=1201; 14-520 measurements per drug) showed the highest average concentrations for oxazepam (0.91 μg/L; RQ = 1.89) and carbamazepine (0.74 μg/L; RQ = 1.48), with individual measurements exceeding ETCs. For other drugs, measured concentrations did not reach the detection limit (amisulpride, (es)citalopram, quetiapine, and venlafaxine) or did not exceed the ETC (fluoxetine). Furthermore, households contributed most to psychotropics in surface water. Finally, psychotropics were cleared less efficiently from a wastewater treatment plant than other medications.ConclusionsPsychotropic drugs are present in surface water, are primarily emitted by households, and may put organisms at risk. We signal a need to reduce concentrations of several psychotropic agents in the environment. Our findings set the stage for policies and research aimed at curtailing emissions of psychotropic drugs into the environment and highlight a need for responsible prescribing and waste measures.Disclosure of InterestNone Declared
Crohn disease and schizophrenia: fortuitous association or etiopathogenic link?
Authors: Zineb B. , Aicha T. , Imane K. , Fouad L. , Abderrazak O. 
Published: August 2023

IntroductionCrohn’s disease is a chronic inflammatory bowel disease of multifactorial etiology. Its association with psychiatric disorders has frequently been reported, mainly with depressive or anxiety disorders.However, its association with schizophrenia remains exceptional.Objectiveswe will try to discuss this association.MethodsIn this regard, we report the case of a young patient, aged 24, diagnosed 5 years ago with Crohn’s disease, evolving by remission flares, currently treated with Azathioprine, after failure of corticosteroid bolus.ResultsThe patient was admitted to psychiatry for aggression towards his parents.In view of the history of the disorders as reported by the family and the psychiatric interview, the diagnosis of schizophrenia was retained and the patient was put on amisulpride.ConclusionsSchizophrenia and Crohn’s disease are relatively frequent diseases, generally occurring at a young age, whose etiopathogenesis, multifactorial, involves in both cases genetic, environmental and immunological factors.Their association does not seem fortuitous and arouses both etiopathogenic and therapeutic interest, but studies involving a large number of patients would make it possible to elucidate the link between these two diseases.Disclosure of InterestNone Declared
THE COMPLEXITY OF DUAL PATHOLOGY: REGARDING A CASE REPORT OF SEIZURES
Authors: De Andrade M. F. , Magalhães M. , Gil L. , Viveiros V. , Moreira C. 
Published: August 2023

IntroductionWernicke’s encephalopathy (WE) is a potentially reversible neuropsychiatric emergency caused by thiamine deficiency, whose classical triad consists of acute onset of confusion, gait ataxia, and oculomotor dysfunction. The diagnosis is missed in 75-80% of cases and approximately 80% of untreated patients develop Korsakoff Syndrome, which is characterized by memory impairment associated with confabulation. Early recognition of nutritional deficiency or any portion of the triad is critical and should prompt treatment, since WE is readily reversible if treated with adequate doses of parenteral thiamine.ObjectivesStarting from a case report of suspected WE, we pretend to discuss the differential diagnosis of seizures in dual pathology.MethodsNon-systematic review of the literature was performed in PubMed database using the keywords “Wernicke’s Encephalopathy”, “Seizures”, “Alcohol” and “Benzodiazepines”. The articles were selected according to their relevance. A patient´s clinical record was reviewed and presented.ResultsWe present a case of a 44-year-old Ukrainian man with suspected background of chronic alcohol abuse and psychiatric history of schizoaffective disorder, who presented with acute onset of confusion, psychomotor agitation, gait ataxia and nystagmus. Anamnesis was hampered by the language barrier and absence of past medical history and patient’s alcoholic habits remained unclear. After suspicion of WE it was introduced thiamine and diazepam, with significant improvement. After discontinuation of diazepam, the patient presented with several episodes of tonic-clonic seizures. He was medicated for seizures with clinical stabilization. At time of discharge the diagnostic discussion prevailed.Seizures are a common presentation of various conditions associated with alcohol use, whose differential diagnosis is difficult, especially in patients with dubious alcohol consumption. Alcohol abuse is a major precipitant of status epilepticus as seizure threshold is raised by alcohol drinking. Seizures may also occur during alcohol withdrawal, for which treatment with benzodiazepines is recommended, however carefully, since both abrupt cessation and high-dose use are critical for the appearance of seizures. Although very rare, WE may also present with seizures, whereby overdiagnosis and overtreatment are preferred to prevent persistent neurocognitive impairments.ConclusionsThis case illustrates the complexity of neuropsychiatric diagnoses in dual pathology. It requires a longitudinal assessment for a better understanding of clinical conditions and establishment of the best therapeutic approach.Disclosure of InterestNone Declared
Cannabinoid Hyperemesis Syndrome - A Case Report of an uncommon condition
Authors: Peixoto B. , Bicho M. , Cruz M. , Mendonça M. , Ustares V. 
Published: August 2023

IntroductionThe increasing prevalence of cannabis use in the world requires awareness of cannabis-related disorders such as cannabinoid hyperemesis syndrome (CHS). CHS is characterized by cyclic episodes of nausea, vomiting and abdominal pain, affecting chronic cannabis users, who usually recur to hot showers to relief the symptoms. The pathophysiology underlying this syndrome is still unclear. Despite the well-established anti-emetic properties of cannabis, there is increasing evidence of its paradoxical effects on the gastrointestinal tract and central nervous system.ObjectivesThe authors pretend to inform the readers about the rare Cannabinoid Hyperemesis Syndrome (CHS).MethodsThe authors describe a case of a 22 years old patient with chronic cannabis use, cyclic and intractable nausea and vomiting, to bring to the attention that this condition exists and is underdiagnosed.ResultsCHS should be strongly considered in the differential diagnosis of persistent vomiting in patients who reports relief with hot showers. In the acute setting, supportive care with intravenous fluids, dopamine antagonists, topical capsaicin cream, and avoidance of narcotic medications has shown some benefit. However, cannabis cessation appears to be the best treatment.ConclusionsCHS prevalence will continue to rise in parallel with increasing worldwide cannabis use and potency. So, health professionals must be aware of this syndrome, its diagnosis, and treatment, to provide better care and avoid overlooking CHS. Further research is required to elicit the exact mechanism and additional therapies for this condition.Disclosure of InterestNone Declared
Depression and Anxiety in Cardiac Disease, diagnosing and screening
Authors: Jupe T. , Provi K. , Zenelaj B. , Myslimi E. , Giannopoulos I. 
Published: August 2023

IntroductionAmong patients with heart disease, such as coronary artery disease or heart failure, depression and anxiety disorders are extremely common. In these populations, 20% to 40% have elevated depressive symptoms, and 15% to 20% suffer from MDD. Anxiety may be even more common than depression. A recent meta-analysis suggests that over 50% of patients with heart failure have elevated rates of anxiety, and 13% meet criteria for an anxiety disorder. These prevalence rates are significantly higher than those in the general population and highlight the high-risk status of cardiac patients for these disorders.ObjectivesThe aim of this study is to highlight the frequency of anxiety and depression in patients with cardiac health problems and to explain the mechanism by which anxiety and depression influence the manifestation of cardiac diseases.MethodsΑ bibliographical review was performed using the PubMED platform. All relevant articles were found using the keywords: depression, anxiety, cardiac disease.ResultsThe links between depression, anxiety, and cardiovascular disease are complex and involve psychological, biological, and behavioral mechanisms. Depression, arrhythmias, and coronary artery disease frequently co-occur because they share common behavioral and pathophysiological drivers-unhealthy lifestyle, autonomic dysregulation, hypothalamic-pituitary-adrenal (HPA) axis dysregulation, endothelial dysfunction, and inflammation-that are intricately related to one another.ConclusionsIn patients with cardiovascular disease, depression and anxiety disorders are common, persistent, and associated with poor functional and cardiac outcomes. As such, making a timely and accurate clinical diagnosis using DSM-5 criteria is critical. Safe and effective treatments are available for the management of these disorders in patients with cardiac disease, and it is hoped that such treatment can improve psychiatric health, quality of life, and medical outcomes.Disclosure of InterestNone Declared
A look at post-pandemic conjugality: a clinical case study
Authors: Pires-Lima C. , Figueiredo M. H. , Salgueiro A. 
Published: August 2023

IntroductionThe co-construction of conjugality is influenced by the interactions established in the family as a whole. It manifests itself, therefore, as a relational model in the expression of affectivity and the management of conflicts.ObjectivesIn this clinical case report, the couple assumes relational difficulties focused on the significant reduction of time in individual leisure activities and, on the other hand, a 24-hour coexistence in the same space, in a period of compulsory confinement due to the COVID-19 pandemic.MethodsThis study is exploratory-descriptive, using the case study as an empirical approach.ResultsThe case described, reports to Couples Therapy, with the sessions taking place in 2022, in a total of seven. The couple, N, male, and J, female, have been married since 2020, shortly before the first confinement because of the COVID-19 pandemic. Regarding their marital relationship, they reported that it deteriorated due to the difficulty in expressing an adaptive reaction to the stressor confinement and the opposite position regarding their desire to become parents.ConclusionsIntegrative strategies were developed, with different theoretical and operative references. The couple took control of their relationship due to a greater empathic awareness and the establishment of a healthy and balanced communication system.Disclosure of InterestNone Declared
The impact of the COVID-19 pandemic on health outcomes in delusional disorder: A systematic review
Authors: Román E. , Natividad M. , Seeman M. V. , Izquierdo E. , Martínez E. , Rial E. , Alvarez A. , Guàrdia A. , Monreal J. A. , González-Rodríguez A. 
Published: August 2023

Introduction
The health impact of the COVID-19 pandemic has been widely recognized in both physical and mental health. Relatively little attention has been paid to patients with delusional disorder (DD).ObjectivesOur goal was to synthesize the known mental and physical health consequences of the COVID-19 pandemic in patients diagnosed with DD.MethodsA systematic review was carried out using the PubMed and Scopus database (2019-October 2022) following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. Search terms: “delusional disorder” or “delusional disorder” AND “COVID-19 OR SARS-CoV2.” Inclusion criteria: 1)DD according to DSM/ICD, 2)languages: English, French, German and Spanish, 3)studies reporting health consequences of COVID-19 pandemic. From a total of 615 records, 6 were included: meta-analysis (n=1), cross-sectional studies (n=2), retrospective study (n=1), case reports (n=2).ResultsA full third of patients with psychosis (including DD) presented with increased psychiatric symptom severity, reportedly activated by increased daily life stress. Suicidal behavior was reported in a previously undiagnosed DD patient in association with a worsening clinical picture. Perhaps surprisingly, admissions for DD in 2020 were lower than in 2019. The duration of hospitalization was, however, longer. There was a report of new onset DD with delusional material centred on COVID. There was also a report of COVID-19 symptoms being more severe in DD patients than in the larger community.ConclusionsHealth emergencies affect the seriously mentally ill more than other community members. Awareness and outreach can help to maintain treatment adherence and minimize risk of psychotic exacerbation.Disclosure of InterestNone Declared