bluuebunny/crossref_metadata_2025_split huggingface dataset:
Discovery of a new polerovirus infecting Bidens pilosa
Authors: Liu Qin-hai , Lan Ping-xiu , Jin Guo-xie , Chen Peng , Tan Guan-lin , Chen Xiao-jiao , Li Ruhui , Li Fan 
Published: February 2023

Abstract
A new virus of the genus Polerovirus in the family Solemoviridae was identified in Bidens Pilosa displaying mosaic and mottle symptoms. Its nearly complete genome of 5,705 nucleotides (nt) contains seven open reading frames (ORFs). The virus shares nucleotide sequence identities 53.2–67.1% with other poleroviruses at whole genome level. The amino acid (aa) sequence identities of each of the five ORFs are less than 84% between the new virus and other known poleroviruses. Phylogenetic analyses showed that the virus was most closely related to beet western yellows virus and cucurbit aphid-borne yellows virus in the genus Polerovirus. Our results suggest that this virus, named “bidens polerovirus 1 (BiPV-1)”, should be a distinct member of the genus Polerovirus. Recombination analysis of the genome sequence of the virus showed that BiPV-1 is a recombinant of the species of two different genera of the family Solemoviridae.
Efficiency Comparison of Public and Private Hospitals before and after the COVID-19 Pandemic: The Case of Hubei, China
Authors: Yin Shicheng , Jia Changli , Yang Ciran , Wu Yuxin , An Shuhan , Mao Zongfu , Cui Dan , Wang Quan 
Published: February 2023

Abstract

BackgroundThe persistence and spread of the COVID-19 pandemic adversely affected the efficiency of hospitals with different ownership. This article aims to compare the differences and changes in technical efficiency of public and private hospitals before and after the pandemic.MethodsWe collected institutional and operational data for all 519 general hospitals (including 243 public and 356 private hospitals) in Hubei province China from 2019 to 2021. Using the slacks-based measure model (SBM), we measured and compared technical efficiency. The effect of the pandemic on hospital efficiency was examined with a two-way fixed effect model and a lasso regression model. PSM, Tobit regression was used for robustness testing.ResultsPublic hospitals were much more efficient than private hospitals both before and after the epidemic in Hubei. The mean efficiency score of public and private hospitals was 0.52 and 0.26 in 2019, 0.37 and 0.22 in 2020, 0.44 and 0.24 in 2021. The difference in efficiency between public and private hospitals was significant in 2019 and 2021(p<0.001). Public hospital efficiency showed a faster recovery in the face of the epidemic.ConclusionsPublic hospitals run by the administrative system have shown greater efficiency and played a major role in the fight against the pandemic. The country's public health protection network should be fortified and efforts should be made to promote the high-quality development of public hospitals. The widening of the overall gap between public and private hospitals appeared. In the post-epidemic era, private hospitals need to prioritize finding the right positioning and offering highly specific medical services in China.
A comparative patient-level prediction study in OMOP CDM demonstrates advantages for native and web-based implementations
Authors: Ahmadi Najia , Nguyen Quang Vu , Sedlmayr Martin , Wolfien Markus 
Published: February 2023

Abstract
Background: The emergence of collaborations, which standardize and combine multiple clinical databases across different regions, provides a wealthy source of data, which is fundamental for clinical prediction models, such as patient-level predictions. With the aid of such large data pools, researchers are able to develop clinical prediction models for improved disease classification, risk assessment, and beyond. To fully utilize this potential, Machine Learning (ML) methods are commonly required to process these large amounts of data on disease-specific patient cohorts. As a consequence, the Observational Health Data Sciences and Informatics (OHDSI) collaborative develops a framework to facilitate the application of ML models for these standardized patient datasets by using the Observational Medical Outcomes Partnership (OMOP) common data model (CDM).
Motivation: In this study, we compare the feasibility of current web-based OHDSI approaches, namely ATLAS and “Patient-level Prediction” (PLP), against a native solution (R based) to conduct such ML-based patient-level prediction analyses in OMOP. This will enable potential users to select the most suitable approach for their investigation.
Methods: Each of the applied ML solutions was individually utilized to solve the same patient-level prediction task. Both approaches went through an exemplary benchmarking analysis to assess the weaknesses and strengths of the PLP R-Package. In this work, the performance of this package was subsequently compared versus the commonly used native R-package called Machine Learning in R 3 (mlr3), and its sub-packages. The approaches were evaluated on performance, execution time, availability of tools for handling imbalanced datasets, and ease of model implementation.
Results: The results show that the PLP package has shorter execution times, which indicates great scalability, as well as intuitive code implementation, and numerous possibilities for visualization. However, limitations in comparison to native packages were depicted in the implementation of specific ML classifiers (e.g., Lasso), which may result in a decreased performance for real-world prediction problems.
Conclusion: The ﬁndings here contribute to the overall effort of developing ML-based prediction models on a clinical scale and provide a snapshot for future studies that explicitly aim to develop patient-level prediction models in OMOP CDM.
Disentangling the erosion protection characteristics of the rammed earth Great Wall in Shanhaiguan and understanding the role of biological crusts with salts
Authors: Liu Liang , Zhang Yun , Guo Lianjun , Cao Haiying , Dai Zhenwei , Zhao Zhiyong , Guo Ying , Li Dongdong , Zheng Lingling , Li Tianli 
Published: February 2023

Abstract
Rammed earth is a green material that is widely used in all kinds of buildings around the world. Rammed earth buildings are often subject to erosion and collapse hazards due to prolonged heavy rainfall and exposure. The Great Wall of Shanhaiguan is a typical world cultural site built of rammed earth. However, an investigation found that there were no erosion marks on the partial walls of the Xiaowan and Nantuzhuang gaps of the Great Wall of Shanhaiguan. To study the reasons why rammed the earth Great Wall have strong erosion resistance, we carried out different experimental tests. The results show that the erosion resistance performance of the rammed earth Great Wall is due to the formation of a gray‒green biological crust layer on the rammed earth surface. Scanning electron microscopy indicated that the polysaccharide organic matter secreted by biological crust caused soil particle agglomeration. Moreover, the algal filaments and the hyphae overlapped, wound and wrapped the soil particles, forming a complex spatial network structure. Together, they improved the soil erosion stability. on the other hand，the high-valent cations in the rainwater and the low-valent cations in the clay exchange ions, forming crystal growth and blocking the soil, also enhance the erosion resistance performance of the wall.
Association of body mass index with clinical outcome of WHO grade 4 glioma
Authors: Wang Jiejun , Hao Zhaonian , Li Ruyuan , Wu Weiqi , Huang Na , Zhang Kangna , Hao Shuyu , Feng Jie , Chu Junsheng , Ji Nan 
Published: February 2023

Abstract
Purpose
The prognostic value of body mass index (BMI) in WHO grade 4 gliomas is not well acknowledged. This study aimed to assess the survival outcomes of patients with different BMI.
Methods
Real-world data of patients diagnosed of WHO grade 4 (2021 version) glioma was assessed in a prospective design. All patients have undergone standard-of-care, from September 2018 to September 2021. Outcomes of overall survival and progression-free survival were analyzed.
Results
127 patients were ultimately admitted in this study. Baseline characteristics of clinical features, molecular features, and secondary treatment in BMI subsets showed no significant difference. Survival analyses showed a significantly superior OS in overweight group comparing to normal weight group. A trend of favoring a better OS of overweight group comparing to obesity group has been observed. Univariate cox regression demonstrated patients of round-BMI 25 and 26 obtained superior OS outcomes under standard-of-care of WHO grade 4 gliomas.
Conclusion
In this real-world setting, overall survival was shown to be improved in patients with overweight. Patients in proper BMI range may acquire survival benefit undergoing standard-of-care of WHO grade 4 gliomas. Large scale studies on these subsets of patients are needed.
S100A9 Regulated M1/M2 Macrophage Polarization in Interleukin-10- induced Promotion of Malignant Pleural Effusion
Authors: Pei Xue-Bin , Yi Feng-Shuang , Dong Shu-Feng , Chen Qing-Yu , Shi Xin-Yu 
Published: February 2023

Abstract
Interlukin-10 (IL-10) promotes the formation and development of malignant pleural effusion (MPE). Previous studies have elucidated the pathogenesis from the view of the immune-regulation function of CD4+ T-cells. However, the underlying mechanism is still not fully understood. In this study, our results showed that IL-10 deficiency reduced the percentage of macrophages in mouse MPE and regulated M1/M2 polarization in vivo and in vitro. The migration capacity of tumor cells was suppressed, and apoptosis was promoted when tumor cells were co-cultured with MPE macrophages in the absence of IL-10. Messenger RNA sequencing of MPE macrophages showed that S100A9 was downregulated in IL-10−/− mice. Bone marrow–derived macrophages obtained from wild-type mice transfected with S100A9-specific small interfering RNAs (siRNAs) also showed less M2 and more M1 polarization than those from the siRNA control group. Furthermore, downregulation of S100A9 using S100A9-specific siRNA suppressed MPE development, decreased macrophages, and modulated macrophage polarization in MPE in vivo. In conclusion, S100A9 plays a vital role in the process of IL-10 deficiency–mediated MPE suppression by regulating M1/M2 polarization, thus influencing the tumor-migration capacity and apoptosis. This could result in clinically applicable strategies to inhibit the formation of MPE by regulating the polarization of MPE macrophages.
Bacteria distribution and drug resistance of a tertiary teaching hospital between 2020 and 2021 in Anhui Province, China
Authors: Liu Lili , Huang Yuan , Wang Yaping , Liu Kang , Li Xiaoyue 
Published: February 2023

Abstract
Background: Antimicrobial resistance has become a worldwide problem.This study aimed to analyze the pathogen distribution and drug resistance of hospital to provide evidence for clinical rational drug use and prevention and control of hospital acquired infection.
Methods: All data were obtained by the application of WHONET 5.6 software. The tested data of microbial specimens were collected during 2 years study period (January 2020- December 2021) to analyze and summarize the pathogens distribution with their resistance spectrum.
Results: We isolated 3246 pathogen strains from inpatients during 2020-2021, including 2434 strains of Gram-negative bacteria (75.0%) and 812 strains of Gram-positive bacteria (25.0%). The top five strains were Escherichia coli (26.5%), Klebsiella pneumoniae (12.7%), Pseudomonas aeruginosa (P. aeruginosa) (11.3%), Acinetobacter baumannii (A. baumannii) (8.5%), Staphylococcus aureus (S. aureus) (8.9%). Bacteria were mainly isolated from urine (31.2%), sputum (26.6%), secretions(20.1%) and blood samples (16.6%). The top three departments of isolation were ICU, Urology Surgery, Neurosurgery Dept. The resistance rates of the main gram-negative bacilli to the second and third generation cephalosporins were between 42%-55%, P. aeruginosa was sensitive to most antibiotics, A. baumannii was generally resistant to common antibiotics. S. aureus, Enterococcus faecalis (E. faecalis) and Enterococcus faecium (E. faecium) were 100% sensitive to linezolid, vancomycin, teicolanin and tegacycline. For most antibiotics, methicillin-resistant S. aureus showed a higher resistance rate to the same antibiotic compared to methicillin-sensitive S.aureus. E. faecalis wasmore sensitive to antibiotics than E. faecium. Carbapenem-resistant A. baumannii was detected as 83.7% in 2021. Carbapenem-resistant enterobacteriaceae increased with Serratia marcescens as a representative. The resistance rate to ertapenem of Serratia marcescens reached to 88.9%.
Conclusion: Gram-negative bacteria were the main bacteria detected. A. baumannii has severe drug resistance. Most multidrug-resistant organism (MDRO) increased by years. It is very necessary to strengthen the rational application of antimicrobial agents and implement the combined prevention measures of MDRO.
Small peptides isolated from enzymatic hydrolysates of Pneumatophorus japonicus head have protective effects on GES-1 cells against alcohol damage
Authors: Tang Yi-Ying , Gao Ming-Hui , Zhang Jie-Shuai , Tao Ning-ping , Wang Xi-Chang , Wang Ping , Deng Shang-Gui , Hong Miao-Si , Lu Ying , Yang Jing-Ya , Xu Chang-Hua H. 
Published: February 2023

Abstract
Stomach mucosal damage posed a great impact on stomach health and may escalated to stomach cancer. Given that gastric mucosal epithelial cells (GES-1) were the foremost essential part of gastric mucosal defense barrier, their repair and protection were crucial for gastric strengthening. In this study, based on "macro-micro-nano-level" molecular spectroscopy, a multi-scale in-situ analysis approach of microscopic imaging, complemented by cellular biological methods, was proposed to systematically investigate the dynamic regulation of home-developed Pneumatophorus japonicus head peptides (PHPs) on the visual-chemical structure and composition distribution of alcohol-damaged GES-1, and subsequently to reveal the interaction mechanism between PHPs and GES-1 components. The results showed that 3-10 kDa PHPs had superior repair and protection effects compared to gastric mucin, significantly promoted cell proliferation, reduced the leakage of lactate dehydrogenase (LDH), and increased the mitochondrial membrane potential (MMP). It was deduced that PHPs promoted synthesis of glycoproteins, enhanced superoxide dismutase (SOD) and inhibited production of reactive oxygen species (ROS), thus achieving protection and repair functions on GES-1. This study provided theoretical and technical reference for the development of new natural gastric repair peptide products with high activity in future.
Construction of model Hamiltonians for the transition-metal impurities via the QSGW method
Authors: Saito Harutaka , Suzuki Katsuhiro , Sato Kazunori , Kotani Takao 
Published: February 2023

Abstract
We show a method to construct model Hamiltonians for describing multiplet excitations of transition-metal impurities. Here we treat systems of a transition metal substituting Al in α-Al2O3. Based on the results of quasiparticle self-consistent GW (QSGW) calculations for the systems, we construct the model Hamiltonian of 3d orbitals. We determine not only the crystal field parameters but also the parameters of effective interactions based on the theoretical correspondence between QSGW calculations and the model Hamiltonian, and investigate systematic change of these parameters. Finally, we discuss the structures of multiplet excitations calculated from these parameters.
EU trade dynamics and the European model in the context of new globalization patterns and global governance
Authors: Bongardt Annnette , Torres Francisco 
Published: February 2023

This article argues that European Union (EU) trade dynamics and (old and new) globalization challenges cannot be seen in isolation from their implications for the European (economic, social, environmental) model. The EU, a staunch defender of free trade and multilateralism, faces an increasingly messy international trading system and new realities that affect its external trade (environmental and geopolitical considerations, industrial policy). Its quest to promote external trade may however sit uneasily with European values, to which EU trade policy reviews pay tribute by letter, most recently enshrining the objectives of the European Green Deal. This article questions the EU’s unfettered defence of the European model in practice through its new generation trade agreements, which are a chief embodiment of its trade policy. Those increasingly stretch into non-traditional areas, which implies that they feed back into the European model in a way that traditional trade agreements have not, via multiple channels, including regulation (standards, also environmental and labour) or investor protection clauses. The issue whether the EU privileges trade over the European model is reflected in the difficulty to find a necessary consensus among member states to ensure the ratification of recent deep trade agreements.
Названия неба в монгольских языках: этимология и семантика
Authors:   Institute of Linguistics of the RAS (bldg. 1/1, Bolshoi Kislovodsky St., Moscow 125009, Russian Federation), Dybo Anna V. , Kukanova Viktoria V. , Mirzaeva Saglara V. , Bembeev Evgeny V. , Mushaev Vladimir N.  , Khoninov Vyacheslav N. ,   Kalmyk Scientific Center of the RAS (8, Ilishkin St., Elista 358000, Russian Federation),   Gorodovikov Kalmyk State University (11, Pushkin street, 358000 Elista, Russian Federation)
Published: February 2023

Introduction. The articles examines etymologies and semantics of Mongolic words denoting the sky. The system of astronomical terms in Mongolic languages is structurally complicated due to multiple layers of pre-Buddhist, Buddhist and other beliefs adopted by proto-Mongols. Goals. The work aims to identify etymological and semantic dominants characterizing this thematic group within the common Mongolic vocabulary. The concept of sky clusters with most basic ones, and lexemes to denote it are to be found in each and every language. Materials and methods. The study examines dictionaries of Mongolic languages, involves reliable proto-Mongolian lexical reconstructions by H. Nugteren and O. Mudrak. Furthermore, the paper analyzes various etymological works and Altaic dictionaries, as well as databases on semantic transitions and colexifications. Results. The Mongolic vocabularies contain four lexemes denoting the sky and two for air/airspace — all of them being largely associated with different beliefs and faiths across different areas and in different eras. So, the word *teŋgeri attests to some elements of the cult of heaven had been practiced by earliest Mongols and the latter had maintained contacts with Turkic groups. The second lexeme *hogtorgui is a Buddhist scholarly term semantically derived from the one denoting emptiness, i.e. a suggested semantic calque from the Sanskrit word that was borrowed to northern Mongolic languages from translated texts of the Buddhist Canon. The third name *köke is a hapax from the Muqaddimat al-Adab that may have arrived in western Middle Mongolian from Chagatai Turkic. The fourth word *asman is a later borrowing from Persian to vocabularies of Muslim Mongols, sometimes via Turkic languages. The fifth lexical unit *agaɣar may have been included from Buddhist Sanskrit, and the sixth word *kei — from Middle Chinese. The unexpected conclusion is that the original proto-Mongolian word to have denoted the sky simply cannot be reconstructed. Evidently, the ancient word had been displaced by the loanwords throughout most intensive cultural contacts.
Intoxicação com aditivos alimentares
Authors: Veras Felipe Eduardo Lages , Fé Fernanda de Sousa Moura , Nunes Isabel da Silva Gonçalves , Costa Isabela Martins , Moura Williany Carvalho , Marques Rosemarie Brandim 
Published: February 2023

Aditivo alimentar constitui qualquer ingrediente adicionado aos alimentos de forma intencional, sem o objetivo de nutrir, apenas com o propósito de alterar as características físicas, químicas, biológicas ou sensoriais dos alimentos. É evidente a importância dos aditivos sob o ponto de vista tecnológico na produção de alimentos. No entanto, é necessário estudar os possíveis riscos toxicológicos que podem ser acarretados pela ingestão frequente dessas substâncias. Nesse sentido, este trabalho objetiva reunir informações sobre os aditivos e os riscos acarretados pelo seu consumo por meio de resgates na literatura em uma revisão sistemática. O estudo caracteriza-se como exploratório descritivo, no qual foram utilizadas como instrumentos de pesquisa as bases de dados LILACS, MEDLINE e SciELO, a fim de reunir trabalhos científicos, publicados entre 2012 e 2016, que abordassem o tema exposto. Utilizaram-se os seguintes descritores: “aditivos alimentares”; “toxicologia dos alimentos” e “indústria alimentícia”. O consumo de alimentos de fácil acesso pela população é crescente em razão da praticidade e ao sabor agradável oferecido, porém o consumo destes produtos pode acarretar em problemas à saúde devido aos inúmeros aditivos químicos utilizados. No que diz respeito à toxicidade desses aditivos, segundo a ANVISA, aromatizantes sintéticos podem causar irritação gástrica; segundo OMS corantes são substancias possivelmente cancerígenas; já o realçador de alimentos em pessoas sensíveis pode causar cefaleia, náusea, fraqueza. Além disso, podem ocorrer alterações descontroladas ou excessivas no organismo do indivíduo, produzidas pelo sistema imunológico, causando uma reação de hipersensibilidade devido à presença de antígenos estranhos. Os principais aditivos relacionados com a hipersensibilidade são os corantes artificiais, utilizados como excipiente de alimentos, estando presentes em inúmeros produtos. Podem ser usados também na fabricação de remédios que podem induzir variados sintomas de hipersensibilidade, na pele, no sistema respiratório ou sintomas gerais. Nesse contexto, faz-se necessário o estudo mais aprofundado sobre os aditivos alimentares e as consequências toxicológicas que oferecem aos consumidores, bem como disponibilizar para a população essas informações no intuito de possibilitar uma mudança nos hábitos alimentares.
FALTA DE ALIMENTAÇÃO E VÍNCULOS PRECÁRIOS EM SERVIÇOS DE SAÚDE MENTAL VOLTADOS PARA USUÁRIOS DE DROGAS: O CASO DO CAPS AD NO RIO DE JANEIRO
Authors: Brandão Beatriz , Barroso Priscila Farfan 
Published: February 2023

Este artigo analisa como a crise no abastecimento de alimentação, o corte de energia elétrica e de água, deu visibilidade ao desmonte do SUS, no que afeta os serviços de saúde mental do Rio de Janeiro. A partir de uma reflexão sobre a mudança das políticas de saúde mental aos usuários de drogas desde a década de 1990, apresentamos o estabelecimento da rede de tais serviços; a implementação das diretrizes da Reforma Psiquiátrica e o atual contexto do desmonte do SUS em serviços de saúde mental. O objetivo do texto é refletir sobre os diferentes impactos sofridos pelas políticas de saúde frente a um cenário de reestruturação das Organizações Sociais (OS), o que acarretou em demissões e corte de trabalhadores. A falta de abastecimento de alimentação e cortes de energia e água nos serviços de saúde mental demonstrou como o desmonte do SUS impacta diretamente no cotidiano dos serviços e na relação profissional x usuário no interior do CAPS AD, resultando em mais sobrecarga e adoecimento da equipe.