bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diversity and temporal distribution of sand flies in an endemic area of cutaneous leishmaniasis in Centre-West Colombia
Authors: Posada-López Laura , Galvis-Ovallos Fredy , Vélez-Mira Andrés , Vélez Ivan D , Galati Eunice A B 
Published: April 2023

Abstract
The community structure of sand flies indicates the level of adaptation of vector species in a region, and in the context of vector management and control, this information allows for identifying the potential risks of pathogen transmission. This study aimed to analyze sand fly diversity and spatial-temporal distribution in an endemic area of cutaneous leishmaniasis. The study was carried out in the Carrizales hamlet (Caldas), between September 2019 and October 2021. The monthly distribution of sand fly species was evaluated through collections with CDC traps. Shannon and evenness indices were calculated and used to compare species frequencies at each house. The association between climatic variables and the frequency of sand flies was evaluated using Spearman’s correlation. A total of 6,265 females and 1,958 males belonging to 23 species were found. Low diversity and evenness were observed, with the dominance of Nyssomyia yuilli yuilli (Young & Porter). Ecological and diversity indices did not reveal differences between the houses. The sand fly community was composed of 3 dominant species, Ny. yuilli yuilli, Psychodopygus ayrozai (Barretto & Coutinho), and Ps. panamensis (Shannon), representing 75.8% of the total catches. No statistical association was found between the absolute frequency of sand flies, rainfall, and temperature. The results show one dominant species, this fact has epidemiological relevance since density influences parasite-vector contact. The high densities of sand flies recorded in peri- and intradomiciliary areas highlight the necessity of periodic monitoring of vector populations and control activities to reduce the risk of Leishmania transmission in this endemic area.
Music-based intervention impacts for people with eating disorders: A narrative synthesis systematic review
Authors: Chang Ee Xuen , Brooker Joanne , Hiscock Richard , O’Callaghan Clare 
Published: April 2023

Abstract
Eating disorders (EDs) can be life-threatening and cause long-term adverse biopsychosocial effects. Treatment options are limited and treatment seeking barriers exist. The objective of this systematic review was to examine the therapeutic impacts of music-based intervention (MBIs) for people with diagnosed EDs. Five bibliographic databases (PsycInfo, MEDLINE, CINAHL, CENTRAL, Open Dissertations) were searched. Eligible studies examined therapeutic outcomes of MBIs in people with EDs, using quantitative and/or qualitative methods. From 939 studies identified, 16 met the inclusion criteria (N = 349; age:12–65-years-old), and were categorized as: music therapy (5 studies), music medicine (4 studies), and “other MBIs” (7 studies), that is, the intervention included music and was delivered by a non-music therapist health worker and/or musician. A narrative synthesis of the studies was undertaken. Participants were diagnosed with anorexia nervosa, bulimia nervosa, binge eating disorder, eating disorder otherwise not specified, or mixed symptoms. MBIs varied widely and were associated with improved mood regulation, emotional well-being, and management of meal-related distress. Vodcast (video podcast) interventions were associated with healthful eating in non-inpatient populations. Studies were assessed using critical appraisal tools. Generalizability of findings is limited due to small samples and suboptimal description of MBIs. Longitudinal research is warranted with larger samples and informed by frameworks for quality reporting of complex MBIs. Review findings may encourage music therapists to further develop and examine how music therapy can help people with EDs to live healthier lives.
Putting Meat to the Test: Imaging and Mechanical Testing Used to Understand the Properties of Meat Alternatives and How They Mimic Our Typical Meat Sensory Experience
Authors: Ko Clara , Davies Andrew , Auty Mark 
Published: April 2023

AbstractAn increasing number of consumers incorporate plant-based products and meat alternatives into their diet. Researchers at Reading Scientific Services Ltd. (RSSL) have performed tensile testing on both chicken and plant-based chicken alternative samples. Using a Linkam MFS stage, the team has assessed the failure point and breaking pattern of each of the samples, to determine which plant-protein product behaved most similarly to the chicken sample. This research offers a path for manufacturers in the meat alternatives industry to better understand the textural differences between chicken and alternative products, and can help inform future new product development for manufacturers looking to expand their product offering.
Integrative single-cell multiomics analyses dissect molecular signatures of intratumoral heterogeneities and differentiation states of human gastric cancer
Authors: Bian Shuhui , Wang Yicheng , Zhou Yuan , Wang Wendong , Guo Limei , Wen Lu , Fu Wei , Zhou Xin , Tang Fuchou 
Published: April 2023

Abstract
Human gastric cancer is a highly lethal disease, but the underlying multiomic molecular signatures remain largely unclear. Here, we performed multi-regional sampling, parallel single-cell multiomics sequencing and integrated analyses of human gastric cancer. We identified common transcriptomic alterations of gastric cancer cells, such as aberrant down-regulation of genes associated with normal stomach function and up-regulation of KRT7, PI3, S100A4, etc. Surprisingly, aberrant and prevalent up-regulation of genes highly expressed in normal colorectal epithelial cells were also identified in cancer cells, which may be partially regulated by promoter chromatin accessibility and DNA methylation levels. We revealed the single-cell DNA methylome landscape of gastric cancer, and identified candidate DNA methylation biomarkers, such as hypermethylated promoters of TMEM240 and HAGLROS, and hypomethylated promoters of TRPM2-AS and HRH1. Additionally, the relationships between genetic lineages, DNA methylation and transcriptomic clusters were systematically revealed at single-cell level. We showed that DNA methylation heterogeneities were mainly among different genetic lineages of cancer cells. Moreover, we found that DNA methylation levels of cancer cells with poorer differentiation states tend to be higher than those of cancer cells with better differentiation states in the primary tumor within the same patient, although still lower than in normal gastric epithelial cells. Cancer cells with poorer differentiation states also prevalently down-regulated MUC1 expression and immune-related pathways, and had poor infiltration of CD8+ T cells. Our study dissected the molecular signatures of intratumoral heterogeneities and differentiation states of human gastric cancer using integrative single-cell multiomics analyses.
Resilience patterns of human mobility in response to extreme urban floods
Authors: Tang Junqing , Zhao Pengjun , Gong Zhaoya , Zhao Hongbo , Huang Fengjue , Li Jiaying , Chen Zhihe , Yu Ling , Chen Jun 
Published: April 2023

ABSTRACT
Large-scale disasters can disproportionately impact different population groups, causing prominent disparity and inequality, especially for the vulnerable and marginalized. Here, we investigate the resilience of human mobility under the disturbance of the unprecedented ‘720’ Zhengzhou flood in China in 2021 using records of 1.32 billion mobile phone signaling generated by 4.35 million people. We find that although pluvial floods can trigger mobility reductions, the overall structural dynamics of mobility networks remain relatively stable. We also find that the low levels of mobility resilience in female, adolescent and older adult groups are mainly due to their insufficient capabilities to maintain business-as-usual travel frequency during the flood. Most importantly, we reveal three types of counter-intuitive, yet widely existing, resilience patterns of human mobility (namely, ‘reverse bathtub’, ‘ever-increasing’ and ‘ever-decreasing’ patterns), and demonstrate a universal mechanism of disaster-avoidance response by further corroborating that those abnormal resilience patterns are not associated with people’s gender or age. In view of the common association between travel behaviors and travelers’ socio-demographic characteristics, our findings provide a caveat for scholars when disclosing disparities in human travel behaviors during flood-induced emergencies.
Risk of Pneumococcal Disease in US Adults by Age and Risk Profile
Authors: Grant Lindsay R , Meche Aster , McGrath Leah , Miles Amanda , Alfred Tamuno , Yan Qi , Chilson Erica 
Published: April 2023

Abstract

Background
Older age and certain medical conditions are known to modify the risk of pneumococcal disease among adults. We quantified the risk of pneumococcal disease among adults with and without medical conditions in the United States between 2016 and 2019.

Methods
This retrospective cohort study used administrative health claims data from Optum's de-identified Clinformatics Data Mart Database. Incidence rates of pneumococcal disease—all-cause pneumonia, invasive pneumococcal disease (IPD), and pneumococcal pneumonia—were estimated by age group, risk profile (healthy, chronic, other, and immunocompromising medical condition), and individual medical condition. Rate ratios and 95% CIs were calculated comparing adults with risk conditions with age-stratified healthy counterparts.

Results
Among adults aged 18–49 years, 50–64 years, and ≥65 years, the rates of all-cause pneumonia per 100 000 patient-years were 953, 2679, and 6930, respectively. For the 3 age groups, the rate ratios of adults with any chronic medical condition vs healthy counterparts were 2.9 (95% CI, 2.8–2.9), 3.3 (95% CI, 3.2–3.3), and 3.2 (95% CI, 3.2–3.2), while the rate ratios of adults with any immunocompromising condition vs healthy counterparts were 4.2 (95% CI, 4.1–4.3), 5.8 (95% CI, 5.7–5.9), and 5.3 (95% CI, 5.3–5.4). Similar trends were observed for IPD and pneumococcal pneumonia. Persons with other medical conditions, such as obesity, obstructive sleep apnea, and neurologic disorders, were associated with increased risk of pneumococcal disease.

Conclusions
The risk of pneumococcal disease was high among older adults and adults with certain risk conditions, particularly immunocompromising conditions.
Spatio-temporal patterning of extensile active stresses in microtubule-based active fluids
Authors: Lemma Linnea M , Varghese Minu , Ross Tyler D , Thomson Matt , Baskaran Aparna , Dogic Zvonimir 
Published: April 2023

Abstract
Microtubule-based active fluids exhibit turbulent-like autonomous flows, which are driven by the molecular motor powered motion of filamentous constituents. Controlling active stresses in space and time is an essential prerequisite for controlling the intrinsically chaotic dynamics of extensile active fluids. We design single-headed kinesin molecular motors that exhibit optically enhanced clustering and thus enable precise and repeatable spatial and temporal control of extensile active stresses. Such motors enable rapid, reversible switching between flowing and quiescent states. In turn, spatio-temporal patterning of the active stress controls the evolution of the ubiquitous bend instability of extensile active fluids and determines its critical length dependence. Combining optically controlled clusters with conventional kinesin motors enables one-time switching from contractile to extensile active stresses. These results open a path towards real-time control of the autonomous flows generated by active fluids.
Autoimmune comorbidities associated with sarcoidosis: a case-control study in the All of Us research program
Authors: Murphy Michael J , Edemobi Princess , Leasure Audrey C , Gulati Mridu , Miller Edward J , Damsky William , Cohen Jeffrey M 
Published: April 2023

AbstractObjectiveThe degree to which sarcoidosis patients are affected by autoimmune diseases is poorly understood. Prior studies of autoimmune co-morbidities in sarcoidosis have focused on populations outside the USA or have been impeded by small sample sizes and limited scope. This case–control study evaluated the association between sarcoidosis and autoimmune diseases in a large, diverse cohort based in the USA.MethodsWe used data from the All of Us research programme to conduct a case–control study involving patients ≥18 years old, from 2018 to the present, diagnosed with sarcoidosis. Sarcoidosis cases and age-, sex- and race-matched controls were identified in a 1:4 ratio. Autoimmune co-morbidities were compared between sarcoidosis patients and controls in univariable and multivariable analyses using logistic regression. The degree of association was measured using the odds ratio (OR).ResultsA total of 1408 sarcoidosis cases and 5632 controls were included in this study. Seven of 24 examined autoimmune diseases were significantly associated with sarcoidosis in our multivariable analysis (P &lt; 0.05). The composite variable of any autoimmune disease was also significantly associated with sarcoidosis (OR = 2.29, P &lt; 0.001).ConclusionWe demonstrate an association between sarcoidosis and multiple autoimmune diseases in a large and diverse cohort based in the USA. These results underscore the need for careful screening of sarcoidosis patients for concomitant autoimmune disease.
A CS-based composite scaffold with excellent photothermal effect and its application in full-thickness skin wound healing
Authors: Wang Jing , Fu Shijia , Li Huishan , Wu Yue 
Published: April 2023

Abstract
The development of natural polymer-based scaffolds with excellent biocompatibility, antibacterial activity, and blood compatibility, able to facilitate full-thickness skin wound healing, remains challenging. In this study, we have developed three chitosan (CS)-based porous scaffolds, including CS, CS/CNT (carbon nanotubes) and CS/CNT/HA (nano-hydroxyapatite, n-HA) using a freeze-drying method. All three scaffolds have a high swelling ratio, excellent antibacterial activity, outstanding cytocompatibility and blood compatibility in vitro. The introduction of CNTs exhibited an obvious increase in mechanical properties and exerts excellent photothermal response, which displays excellent healing performance as a wound dressing in mouse full-thickness skin wound model when compared to CS scaffolds. CS/CNT/HA composite scaffolds present the strongest ability to promote full-thickness cutaneous wound closure and skin regeneration, which might be ascribed to the synergistic effect of photothermal response from CNT and excellent bioactivity from n-HA. Overall, the present study indicated that CNT and n-HA can be engineered as effective constituents in wound dressings to facilitate full-thickness skin regeneration.
Developmental Relationships between Attention Problems and Reading Skills in Black and White Elementary School Students
Authors: Rabiner Eisensmith Sarah , Kainz Kirsten , Ansong David , Harris-Britt April , Bowen Gary L , Albritton Travis J , Loeb Hayden 
Published: April 2023

Abstract
Academic performance in preschool and early elementary grades has long been linked with child attention problems. There is empirical and theoretical support that this co-occurrence is attributable to longitudinal relations between attention and reading problems. However, the literature to date—coming primarily from psychology disciplines—has insufficiently explored the possibility that the relationship between attention problems and reading performance affects students differentially. Using data from the Early Childhood Longitudinal Study, this inquiry extends the current literature by examining whether initial scores and rates of change in the relationship between attention problems and later reading performance vary by child’s race, gender, and socioeconomic status (SES). Findings support the claim that attention and reading develop in a mutual process and reveal a complicated pattern of social and individual predictors of attention reading growth over time. Social work researchers can reframe and reinvestigate evidence derived from a psychological framing of the dual developmental processes of reading and attention within a broader understanding of the nested nature of child development within structures of oppression.
Effects of Neoliberalism on Social Work Practice in the United States: A Scoping Review
Authors: Toft Jessica , Lightfoot Elizabeth B , Calhoun Molly , Choy-Brown Mimi , Merighi Joseph R , Renner Lynette M , Soffer-Elnekave Ruti , Mendel Jessica , Marsalis Scott 
Published: April 2023

Abstract
Neoliberalism, as an ideology and policy model that favors free market logic, operates across multiple levels of social work practice. Although there is growing interest in the topic, there is a lack of knowledge about the nature of this scholarship. The purpose of this scoping review was to provide a synthesis and summary of the extent, variety, and characteristics of the peer-reviewed literature on the effects of neoliberalism on social work practice in the United States. A total of 132 articles were examined according to the requirements of the Preferred Reporting Items for Systematic Review and Meta-analyses extension for scoping reviews (or PRISMA-ScR). Findings suggest that research interest on neoliberalism and social services across disciplines has increased over the last four decades. Social work scholars and journals published at similar rates as non–social work scholars with notable exceptions of policy design and service users. However, there is a lack of research across the literature on the effects of neoliberalism on the supervisor level and the effects of neoliberalism on diverse populations and on key social work services, such as substance use treatment, health services, schools, corrections, and mental health services. Further research is needed in these areas to advance our understanding of the impact of neoliberalism on social work practice.
A roadmap for early psychosocial support in palliative care for people impacted by ALS—reducing suffering, building resiliency, and setting the stage for delivering timely transdiagnostic psychosocial care
Authors: Rush Christina L , Lester Ethan G , Berry James D , Brizzi Kate T , Lindenberger Elizabeth C , Curtis Jared Randall , Vranceanu Ana-Maria 
Published: April 2023

Abstract
This commentary describes the current state of psychosocial care for people with amyotrophic lateral sclerosis and their caregivers. We provide recommendations for developing a roadmap for future research based on existing literature and our group’s clinical and research experience to inform next steps to expand evidence-based psychosocial care for people with amyotrophic lateral sclerosis and their caregivers, with potential implications for a range of advanced illnesses.
Gigaxonin is required for intermediate filament transport
Authors: Renganathan Bhuvanasundar , Zewe James P. , Cheng Yuan , Paumier Jean‐Michel , Kittisopikul Mark , Ridge Karen M. , Opal Puneet , Gelfand Vladimir I. 
Published: April 2023

AbstractGigaxonin is an adaptor protein for E3 ubiquitin ligase substrates. It is necessary for ubiquitination and degradation of intermediate filament (IF) proteins. Giant axonal neuropathy is a pathological condition caused by mutations in the GAN gene that encodes gigaxonin. This condition is characterized by abnormal accumulation of IFs in both neuronal and non‐neuronal cells; however, it is unclear what causes IF aggregation. In this work, we studied the dynamics of IFs using their subunits tagged with a photoconvertible protein mEOS 3.2. We have demonstrated that the loss of gigaxonin dramatically inhibited transport of IFs along microtubules by the microtubule motor kinesin‐1. This inhibition was specific for IFs, as other kinesin‐1 cargoes, with the exception of mitochondria, were transported normally. Abnormal distribution of IFs in the cytoplasm can be rescued by direct binding of kinesin‐1 to IFs, demonstrating that transport inhibition is the primary cause for the abnormal IF distribution. Another effect of gigaxonin loss was a more than 20‐fold increase in the amount of soluble vimentin oligomers in the cytosol of gigaxonin knock‐out cells. We speculate that these oligomers saturate a yet unidentified adapter that is required for kinesin‐1 binding to IFs, which might inhibit IF transport along microtubules causing their abnormal accumulation.
The genomic and evolutionary landscapes of anaplastic thyroid carcinoma
Authors: Zeng Peter Y.F. , Prokopec Stephenie D. , Lai Stephen Y. , Pinto Nicole , Chan-Seng-Yue Michelle A. , Clifton-Bligh Roderick , Williams Michelle D. , Howlett Christopher J. , Plantinga Paul , Cecchini Matthew , Lam Alfred K. , Siddiqui Iram , Wang Jianxin , Sun Ren X. , Watson John D. , Korah Reju , Carling Tobias , Agrawal Nishant , Cipriani Nicole , Ball Douglas , Nelkin Barry , Rooper Lisa M. , Bishop Justin A. , Garnis Cathie , Berean Ken , Nicolson Norman G. , Weinberger Paul , Henderson Ying C. , Lalansingh Christopher M. , Tian Mao , Yamaguchi Takafumi N. , Livingstone Julie , Salcedo Adriana , Patel Krupal , Vizeacoumar Frederick , Datti Alessandro , Xi Liu , Nikiforov Yuri E. , Smallridge Robert , Copland John A. , Marlow Laura A. , Hyrcza Martin D. , Delbridge Leigh , Sidhu Stan , Sywak Mark , Robinson Bruce , Fung Kevin , Ghasemi Farhad , Kwan Keith , MacNeil S. Danielle , Mendez Adrian , Palma David A. , Khan Mohammed I. , Shaikh Mushfiq , Ruicci Kara M. , Wehrli Bret , Winquist Eric , Yoo John , Mymryk Joe S. , Rocco James W. , Wheeler David , Scherer Steve , Giordano Thomas J. , Barrett John W. , Faquin William C. , Gill Anthony J. , Clayman Gary , Boutros Paul C. , Nichols Anthony C. 
Published: April 2023

AbstractAnaplastic thyroid carcinoma is arguably the most lethal human malignancy. It often co-occurs with differentiated thyroid cancers, yet the molecular origins of its aggressivity are unknown. We sequenced tumor DNA from 329 regions of thyroid cancer, including 213 from patients with primary anaplastic thyroid carcinomas and multi-region whole-genome sequencing. Anaplastic thyroid carcinomas have a higher burden of mutations than other thyroid cancers, with distinct mutational signatures and molecular subtypes. Specific cancer driver genes are mutated in anaplastic and differentiated thyroid carcinomas, even those arising in a single patient. We unambiguously demonstrate that anaplastic thyroid carcinomas share a genomic origin with co-occurring differentiated carcinomas, and emerge from a common malignant field through acquisition of characteristic clonal driver mutations.
Development & Deployment of a Real-time Healthcare Predictive Analytics Platform
Authors: Boussina Aaron , Shashikumar Supreeth , Amrollahi Fatemeh , Pour Hayden , Hogarth Michael , Nemati Shamim 
Published: April 2023

AbstractThe deployment of predictive analytic algorithms that can safely and seamlessly integrate into existing healthcare workflows remains a significant challenge. Here, we present a scalable, cloud-based, fault-tolerant platform that is capable of extracting and processing electronic health record (EHR) data for any patient at any time following admission and transferring results back into the EHR. This platform has been successfully deployed within the UC San Diego Health system and utilizes interoperable data standards to enable portability.Clinical relevanceThis platform is currently hosting a deep learning model for the early prediction of sepsis that is operational in two emergency departments.