bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cyclophilin D-mediated Mitochondrial Permeability Transition Regulates Mitochondrial
Function
Authors: Zhou Shaoyun , Yu Qinwei , Zhang Luyong , Jiang Zhenzhou 
Published: March 2023

Background:
Mitochondria are multifunctional organelles, which participate in biochemical processes.
Mitochondria act as primary energy producers and biosynthetic centers of cells, which are involved in oxidative
stress responses and cell signaling transduction. Among numerous potential mechanisms of mitochondrial
dysfunction, the opening of the mitochondrial permeability transition pore (mPTP) is a major determinant of mitochondrial
dysfunction to induce cellular damage or death. A plenty of studies have provided evidence that the
abnormal opening of mPTP induces the loss of mitochondrial membrane potential, the impairment calcium
homeostasis and the decrease of ATP production. Cyclophilin D (CypD), localized in the mitochondrial transition
pore, is a mitochondrial chaperone that has been regarded as a prominent mediator of mPTP.

Methods:
This review describes the relationship between CypD, mPTP, and CypD-mPTP inhibitors through
systematic investigation of recent relevant literature.

Results:
Here, we have highlighted that inhibiting the activity of CypD protects models of some diseases, including
ischaemia/reperfusion injury (IRI), neurodegenerative disorders and so on. Knockdown studies have demonstrated
that CypD possibly is mediated by its peptidyl-prolyl cis-trans isomerase activity, while the primary
targets of CypD remain obscure. The target of CypD-mPTP inhibitor can alleviate mPTP opening-induced cell
death. The present review is focused on the role of CypD as a prominent mediator of the mPTP, further providing
insight into the physiological function of mPTP and its regulation by CypD.

Conclusion:
Blocking the opening of mPTP by inhibiting CypD might be a new promising approach for suppressing
cell death, which will suggest novel therapeutic approaches for mitochondria-related diseases.
Safety and Efficacy of Genistein in Sanfilippo Syndrome - A Systematic
Review
Authors: Majid Haya , Masoom Md. , Khan Mohd. Ashif , Garg Aakriti 
Published: March 2023

Background:
Sanfilippo syndrome, commonly known as mucopolysaccharidosis type III
(MPS III), is a rare autosomal recessive lysosomal storage disease that primarily affects the brain and
spinal cord. It is caused by a deficiency of enzymes involved in the catabolism of glycosaminoglycan
(GAG) and heparin sulfate (HS). Although Genistein has been presented as a potential therapeutic, its
safety and efficacy for the treatment of Sanfilippo syndrome are not well established.

Objective:
This systematic review aims to evaluate the safety and efficacy of Genistein with a primary
endpoint of providing an inference whether the medication is producing any improvements when administered
in patients suffering from Sanfilippo syndrome.

Methods:
An intensive computerized literature search was performed according to PRISMA guidelines
in major databases such as PubMed, ScienceDirect, Embase, Science Citation Index Expanded,
The Cochrane Library, and Web of Science until 30 April 2022. Studies evaluating the efficacy and
safety of genistein in patients with Sanfilippo Syndrome were included. The quality of the included
studies was assessed using the New Castle Ottawa Scale.

Results:
A total of 558 studies were identified in the initial search. After removing duplicates, 25 studies
were screened based on title and abstract, of which 06 studies were included in this systematic review.
Among them, 02 studies were of high quality and 04 studies were of moderate quality. After
administration of genistein, a decrease in urinary GAG levels and HS levels was observed.

Conclusion:
Based on the limited evidence present in the literature, this systematic review suggests
that genistein can be safely used to treat Sanfilippo syndrome as it lowers GAG levels. However, data
on the long-term benefit profile of genistein and high-quality evidence are still needed as a conclusive
result could not be withdrawn.
Corneal Epithelial Development and the Role of Induced Pluripotent Stem
Cells for Regeneration
Authors: Selvarajah Komathi , Tan Jun Jie , Shaharuddin Bakiah 
Published: March 2023

Abstract:
Severe corneal disorders due to infective aetiologies, trauma, chemical injuries, and chronic
cicatricial inflammations, are among vision-threatening pathologies leading to permanent corneal scarring.
The whole cornea or lamellar corneal transplantation is often used as a last resort to restore vision.
However, limited autologous tissue sources and potential adverse post-allotransplantation sequalae urge
the need for more robust and strategic alternatives. Contemporary management using cultivated corneal
epithelial transplantation has paved the way for utilizing stem cells as a regenerative potential. Humaninduced
pluripotent stem cells (hiPSCs) can generate ectodermal progenitors and potentially be used for
ocular surface regeneration. This review summarizes the process of corneal morphogenesis and the signaling
pathways underlying the development of corneal epithelium, which is key to translating the maturation
and differentiation process of hiPSCs in vitro. The current state of knowledge and methodology for
driving efficient corneal epithelial cell differentiation from pluripotent stem cells are highlighted.
The Effectiveness of Wearable Devices Using Artificial Intelligence for Blood Glucose Level Forecasting or Prediction: Systematic Review
Authors: Ahmed Arfan , Aziz Sarah , Abd-alrazaq Alaa , Farooq Faisal , Househ Mowafa , Sheikh Javaid 
Published: March 2023

Background
In 2021 alone, diabetes mellitus, a metabolic disorder primarily characterized by abnormally high blood glucose (BG) levels, affected 537 million people globally, and over 6 million deaths were reported. The use of noninvasive technologies, such as wearable devices (WDs), to regulate and monitor BG in people with diabetes is a relatively new concept and yet in its infancy. Noninvasive WDs coupled with machine learning (ML) techniques have the potential to understand and conclude meaningful information from the gathered data and provide clinically meaningful advanced analytics for the purpose of forecasting or prediction.

Objective
The purpose of this study is to provide a systematic review complete with a quality assessment looking at diabetes effectiveness of using artificial intelligence (AI) in WDs for forecasting or predicting BG levels.

Methods
We searched 7 of the most popular bibliographic databases. Two reviewers performed study selection and data extraction independently before cross-checking the extracted data. A narrative approach was used to synthesize the data. Quality assessment was performed using an adapted version of the Quality Assessment of Diagnostic Accuracy Studies-2 (QUADAS-2) tool.

Results
From the initial 3872 studies, the features from 12 studies were reported after filtering according to our predefined inclusion criteria. The reference standard in all studies overall (n=11, 92%) was classified as low, as all ground truths were easily replicable. Since the data input to AI technology was highly standardized and there was no effect of flow or time frame on the final output, both factors were categorized in a low-risk group (n=11, 92%). It was observed that classical ML approaches were deployed by half of the studies, the most popular being ensemble-boosted trees (random forest). The most common evaluation metric used was Clarke grid error (n=7, 58%), followed by root mean square error (n=5, 42%). The wide usage of photoplethysmogram and near-infrared sensors was observed on wrist-worn devices.

Conclusions
This review has provided the most extensive work to date summarizing WDs that use ML for diabetic-related BG level forecasting or prediction. Although current studies are few, this study suggests that the general quality of the studies was considered high, as revealed by the QUADAS-2 assessment tool. Further validation is needed for commercially available devices, but we envisage that WDs in general have the potential to remove the need for invasive devices completely for glucose monitoring in the not-too-distant future.

Trial Registration
PROSPERO CRD42022303175; https://tinyurl.com/3n9jaayc
Accuracy of Artificial Intelligence–Based Automated Quantitative Coronary Angiography Compared to Intravascular Ultrasound: Retrospective Cohort Study
Authors: Moon In Tae , Kim Sun-Hwa , Chin Jung Yeon , Park Sung Hun , Yoon Chang-Hwan , Youn Tae-Jin , Chae In-Ho , Kang Si-Hyuck 
Published: March 2023

Background
An accurate quantitative analysis of coronary artery stenotic lesions is essential to make optimal clinical decisions. Recent advances in computer vision and machine learning technology have enabled the automated analysis of coronary angiography.

Objective
The aim of this paper is to validate the performance of artificial intelligence–based quantitative coronary angiography (AI-QCA) in comparison with that of intravascular ultrasound (IVUS).

Methods
This retrospective study included patients who underwent IVUS-guided coronary intervention at a single tertiary center in Korea. Proximal and distal reference areas, minimal luminal area, percent plaque burden, and lesion length were measured by AI-QCA and human experts using IVUS. First, fully automated QCA analysis was compared with IVUS analysis. Next, we adjusted the proximal and distal margins of AI-QCA to avoid geographic mismatch. Scatter plots, Pearson correlation coefficients, and Bland-Altman were used to analyze the data.

Results
A total of 54 significant lesions were analyzed in 47 patients. The proximal and distal reference areas, as well as the minimal luminal area, showed moderate to strong correlation between the 2 modalities (correlation coefficients of 0.57, 0.80, and 0.52, respectively; P<.001). The correlation was weaker for percent area stenosis and lesion length, although statistically significant (correlation coefficients of 0.29 and 0.33, respectively). AI-QCA tended to measure reference vessel areas smaller and lesion lengths shorter than IVUS did. Systemic proportional bias was not observed in Bland-Altman plots. The biggest cause of bias originated from the geographic mismatch of AI-QCA with IVUS. Discrepancies in the proximal or distal lesion margins were observed between the 2 modalities, which were more frequent at the distal margins. After the adjustment of proximal or distal margins, there was a stronger correlation of proximal and distal reference areas between AI-QCA and IVUS (correlation coefficients of 0.70 and 0.83, respectively).

Conclusions
AI-QCA showed a moderate to strong correlation compared with IVUS in analyzing coronary lesions with significant stenosis. The main discrepancy was in the perception of the distal margins by AI-QCA, and the correction of margins improved the correlation coefficients. We believe that this novel tool could provide confidence to treating physicians and help in making optimal clinical decisions.
Pengaruh Pelayanan Prima pada Front Office dalam Menjaga Loyalitas Tamu Domestik pada Masa Pendemi Covid-19 Di Kaamala Resort, Ubud
Authors: Sumarini Ni Komang , Susanti Luh Eka 
Published: March 2023

Pelayanan merupakan tindakan yang dilakukan dengan berinteraksi melalui fisik dengan seseorang atau lebih demi mendapatkan kepuasan pelanggan. Adapun pelayanan prima adalah segala upaya yang dilakukan oleh sebuah perusahaan dalam memberikan pelayanan terbaik kepada tamu atau konsumen untuk menghasilkan sebuah kepuasan dan loyalitas pelanggan atau konsumen itu sendiri. Adapun tujuan dari penelitian ini yaitu untuk mengetahui pengaruh pelayanan prima pada front office dalam menjaga loyalitas tamu domestik pada masa pandemi covid-19 di Kaamala resort, Ubud.Penelitian ini menggunakan pendekatan kuantitatif dengan bantuan program SPSS. Menurut hasil analisis olah data yang dilakukan pelayanan prima front office berpengaruh secara signifikan terhadap loyalitas tamu domestik pada masa pandemi covid-19 di Kaamala resort, Ubud. Meskipun begitu, pelayanan prima yang dilakukan belum begitu optimal dengan adanya tamu yang mengeluhkan lamanya proses check in yang dilakukan. Saran yang penulis dapat berikan yaitu meningkatkan komunikasi, kerja sama team, serta ketelitian dalam mengecek bookingan reservasi yang akan tiba. Sehingga pelayanan prima tersampaikan dengan sangat baik oleh tamu domestik yang mana nantinya akan menghasilkan loyalitas penuh oleh tamu domestik.

Service is an action taken by interacting physically with someone or more in order to get customer satisfaction. The excellent service is all the efforts made by a company to supply the best service to guests or consumers to produce a satisfaction and loyalty of customers or consumers themselves. The purpose of this research is to determine the effect of excellent service at the front office in maintaining the loyalty of domestic guests during the covid-19 pandemic at Kaamala resort, Ubud. This study uses a quantitative approach with the help of the SPSS program. According to the results of data processing analysis carried out by excellent front office services, it significantly affected the domestic guests loyalty during the COVID-19 pandemic at Kaamala resort, Ubud. However, the excellent service carried out has not been optimal with guests complaining about the length of the check-in process. The advice that the author can give is to improve communication, teamwork, and accuracy in checking upcoming reservation bookings. Thus, that excellent service is delivered very well by domestic guests which will result in full loyalty by domestic guests.
Kualitas Pelayanan Bellboy di Courtyard by Marriott Bali Nusa Dua Resort
Authors: Warmadewa I Made Prahlada Gusti 
Published: March 2023

Penelitian ini yang berjudul “Kualitas Pelayanan Bellboy di Courtyard by Marriott Bali Nusa Dua Resort” yang membahas kualitas pelayanan bellboy berdasarkan 5 variabel “RATER” yaitu responsiveness, assurance, tangible, empathy, & reliability. Penelitian ini bertujuan untuk mengetahui kualitas pelayanan bellboy di Courtyard by Marriott Bali Nusa Dua Resort. Penelitian ini merupakan penelitian kuantitatif dengan menggunakan kuesioner sebagai teknik pengumpulan data dengan analisis uji validitas, uji reliabilitas. Pengumpulan sampel menggunakan sampel Non propability dan jumlah responden dalam penelitian ini yang berjumlah 30 orang tamu yang menginap di hotel yang ditemui secara kebetulan di area hotel Courtyard by Marriott Bali Nusa Dua Resort. Hasil dari penelitian yang didapat yaitu deskripsi data dari masing-masing variabel kualitas pelayanan Bellboy yaitu : tangible (4,36), realibility (4.10), responsive (4,16), empathy (4,34), dan assurance (4,15). Dimana dapat ditarik kesimpulan yaitu kualitas pelayanan Bellboy di Courtyard By Marriot Bali Nusa Dua Resort menunjukan rata-rata baik, dengan 3 variabel kualitas pelayanan menunjukan hasil yang baik dan 2 variabel kualitas pelayanan menunjukan hasil sangat baik.

This study, entitled "Quality of Bellboy Service at Courtyard by Marriott Bali Nusa Dua Resort" which discusses the quality of bellboy service based on 5 variables "RATER" , as follows responsiveness, assurance, tangible, empathy, & reliability. The purpose of this research was to determine the quality of service bellboys at Courtyard by Marriott Bali Nusa Dua Resort. This research is a quantitative research and information were collected by a questionnaires with analysis of validity and reliability test. The collection of samples using non-probability samples and the amount of respondents in this study was 30 guests staying at the Courtyard by Marriott Bali Nusa Dua Resort hotel area. The results of the research obtained are descriptions of data from each Bellboy service quality variable, as follows; tangible (4.36), reliability (4.10), responsive (4.16), empathy (4.34), and assurance (4.15 ). Where it can be concluded that the service quality of Bellboy at the Courtyard By Marriot Bali Nusa Dua Resort shows a good average, with 3 service quality variables showing good results and 2 service quality variables showing very good results.
Implementasi Metode Up-Selling di Potato Head Beach Club
Authors: Dinatai Putu Agus Krisna , Sanjiwani Gusti Agung Mirah 
Published: March 2023

Implementasi metode up-selling kurang optimal dilakukan oleh pramusaji di Potato Head Beach Club. Hal ini dapat dilihat dari kurangnya tindak lanjut dan pemeliharaan terhadap standar up-selling yang dilakukan oleh pramusaji di Potato Head Beach Club. Tujuan penelitian adalah mengetahui implementasi dan faktor-faktor pramusaji melakukan metode up-selling di Potato Head Beach Club. Penelitian menggunakan pendekatan deskriptif kualitatif dengan metode pengumpulan data dengan cara observasi, wawancara, dan studi dokumentasi. Hasil penelitian menunjukkan bahwa implementasi metode up-selling berdasarkan teori ahli yang diterapkan pada standar operasional prosedur di Potato Head Beach Club sudah dilaksanakan dengan baik seperti: mencari calon pelanggan/pembeli, melakukan pendekatan kepada calon pelanggan/pembeli, presentasi dan demonstrasi, mengatasi keberatan atau penolakan, penutupan. Namun ada satu (1) poin yang belum di lakukan dengan baik, yaitu melakukan tindak lanjut dan pemeliharaan seperti melakukan quality check terhadap makanan yang disajikan. Faktor yang mendukung pramusaji dalam mengimplementasikan up-selling adalah product knowledge, first impression dan pendekatan yang pramusaji dilakukan dan faktor cuaca. Manajemen Potato Head Beach Club diharapkan agar lebih meningkatkan pelatihan tentang product knowledge dan memaksimalkan implementasi up-selling di Potato Head Beach Club, agar tetap sejalan dengan standar yang sudah di tetapkan oleh perusahaan.

The implementation of the less than optimal up-selling method was carried out by the waitress at Potato Head Beach Club. This can be seen from the lack of follow-up and maintenance of up-selling standards by the waiters at Potato Head Beach Club. The purpose of the study was to determine the implementation and factors of the waiter doing the up-selling method at Potato Head Beach Club. The study used a qualitative descriptive approach with data collection methods by observation, interviews, and documentation studies. The results show that the implementation of the up-selling method based on expert theory applied to standard operating procedures at Potato Head Beach Club has been carried out well such as: looking for prospective customers/buyers, approaching potential customers/buyers, presentations and demonstrations, overcoming objections or complaints, rejection, and farewell. However, there is one (1) point that has not been done well, namely carrying out follow-up and maintenance such as conducting quality checks on the food served. Factors that support waiters in implementing up-selling are product knowledge, first impressions and the approach that the waiter takes and weather factors. Potato Head Beach Club management is expected to improve training on product knowledge and implementation of up-selling at Potato Head Beach Club, in order to stay in line with the standards set by the company.
Analisis Pengaruh Visibility Credibility Attraction Power Celebrity Endorsment Terhadap Minat Kunjungan Tamu di Hotel Four Points by Sheraton Manado
Authors: Supit Enrico , Sudarmawan I Wayan Eka , Rinayanthi Ni Made 
Published: March 2023

Penelitian membahas tentang pengaruh promosi yang dilakukan oleh selebgram Anggia Kloer dalam mempromosikan fasiltas dan event – event yang akan diadakan melalui selebgram dengan maksud meningkatkan kepercayaan konsumen di Manado agar dapat dikenal oleh banyak orang. Tujuan dari penelitian ini untuk mengetahui apakah visibility, credibility, attraction, power berpengaruh positif dan signifikan terhadap minat kunjungan tamu di hotel Four Points by Sheraton Manado. Populasi dalam penelitian ini adalah tamu yang pernah menginap di Four Points By Sheraton Manado, mempunyai instagram dan mengikuti Anggia Kloer di instagram. Sampel Penelitian ini berjumlah 40 orang. Data penelitian ini diperoleh dengan menyebarakan kuesioner secara online menggunakan Google Form kepada responden. Teknik analisis statik yang digunakan adalah regresi linier berganda, uji validitas, uji reliabiltas, uji t, dan uji f. Berdasarkan hasil Visibility, credibility, attraction dan power selebgram secara parsial berpengaruh positif dan signifikan terhadap minat kunjungan di Hotel Four Point by Sheraton Manado. Visibility, credibility, attraction dan power selebgram secara simultan berpengaruh positif dan signifikan terhadap minat kunjungan di Hotel Four Point by Sheraton Manado.

The study discusses the influence of promotions carried out by selebgram Anggia Kloer inpromoting facilities and events that will be held through the program with selebgram of increasing consumer confidence in Manado so that it can be known by many people. The purpose of this study was to determine whether visibility, credibility, attraction, power had a positive and significant effect on the interest of visiting guests at the Four Points by Sheraton Manado hotel. The population in this study are guests who have stayed at Four Points by Sheraton Manado, have Instagram and follow Anggia Kloer on Instagram. The sample of this study amounted to 40 people. The research data was obtained by distributing online questionnaires using Google Form to respondents. Static analysis techniques used are multiple linear regression, validity test, reliability test, t test, and f test. Based on the results of Visibility, credibility, attraction and power of the program, partially positive and significant effect on interest in visiting the Four Point Hotel by Sheraton Manado. Visibility, credibility, attraction and power of the program simultaneously have a positive and significant effect on interest in visiting the Four Point Hotel by Sheraton Manado.
Gingival Conditioning with Provisional Composite Veneer Prior to Final Dental Restoration: Three-year Follow-up
Authors: Mueller B , Rauber GB , Linhares LA , Bernardon JK , Santini E , Pottmaier LF 
Published: March 2023

SUMMARY
This manuscript reports a three-year follow-up of a case of gingival conditioning with a provisional composite veneer prior to diastema closure and tooth recontouring with direct composites. This conservative treatment resulted in a natural and harmonious smile.
Polychromatic Composite and Resin Infiltration Restorations in the Esthetic Zone: A Five-year Clinical Report
Authors: Karimi K , Fischer NG , Jurado CA , Villalobos-Tinoco J , Tsujimoto A 
Published: March 2023

SUMMARY

Objective
This case report describes the use of a combination of a polychromatic resin composite restoration and resin infiltration to achieve a satisfactory esthetic outcome that has lasted over five years.

Clinical Considerations
The patient’s primary complaint was a desire to replace an existing stained resin composite on the facial and mesial surfaces of the maxillary left central incisor, and a white spot on the facial surface of the maxillary right central incisor. After clinical evaluation, the patient was offered either replacement of the restoration with a polychromatic restoration simulating a white spot, or a combined treatment with polychromatic composite and resin infiltration restorations, which was recommended. The patient selected the latter treatment. A putty matrix was fabricated, and a quick mock-up was done using various enamel and dentin shades of resin composite to determine proper material selection. The previous resin composite restoration was removed, and layers of new dentin, body, and enamel composite were placed. An interproximal matrix was used in order to provide ideal contour and contact. Finishing and polishing procedures were performed. The maxillary right central incisor was treated with resin infiltration in order to subdue the white spot on the facial surface.

Conclusions
Polychromatic resin composite and resin infiltration restorations to replace a stained restoration and mask a white spot can achieve desired results in the esthetic zone and maintain them for five years.