bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quality Of Life Of HIV Positive Patients Attending Anti-Retroviral Clinic in Enugu, Nigeria.
Authors: Ogbodo Okechukwu Chime , Ossai Edmund Ndudi 
Published: August 2023

Abstract

INTRODUCTION:Globally, more than 70 million people have been infected with the HIV virus and about 35 million people have died of HIV related causes since 1981.OBJECTIVE:To assess the quality of life of HIV positive patients attending Anti-retroviral clinic in Enugu State University Teaching Hospital, Enugu, Nigeria.METHODOLOGY:This cross sectional study was carried out among 400 respondents selected by systematic sampling. Fisher Exact and chi square test, Student t-test, and Spearman’s correlation were used where appropriate. The level of statistical significance was set at p < 0.05.RESULTS:Majority (75%) of the respondents were female, and more than half (54.3%) were more than 38 years old. A high proportion (77.5%) perceived their overall quality of life to be in excellent. Those 38 years and above had the best quality of life, while those within the age group 18 to 22 years had the worst quality of life. Married or widowed respondents had better excellent quality of health than those who were separated or single. The quality of life of majority of the respondents was mostly affected by lack of money (75.8%) and their physical condition (24.3%). Also, most of the respondents (56.2%) who were ill had the least quality of life, while those who were not ill (87.5%) had better quality of life. Majority of the respondents (68.3%) were satisfied with their physical condition. While 75.8% were satisfied with their psychological feelings.CONCLUSION AND RECOMMENDATIONS:The overall quality of life of majority of the respondents was good, and majority of them were satisfied with their current health status. There should be improvement on early diagnosis and treatment, including provision of social support services.
Effects of exogenous self-made active humic acid manure on physical and chemical properties and soil bacteria of continuous cropping obstacle soil in Capsicum annuum L
Authors: Deng Tingfei , Deng Tingfei , Yan Yanfang , Liu Xiaolan , Guan Zhengce , Yang Fenghua , Ge Lijuan , Pan Xiong , Gao Ming , Yan Qiuxiao , Gao Anqin , Wang Daoping , Peng Mei , Luo Zhongsheng , Yang Lishou , Li Liangqun , Yang Xiaosheng 
Published: August 2023

Abstract
Aims Capsicum annuum
L. is a widely cultivated horticultural crop known for its pungent varieties and culinary significance. However, the production of chili pepper has been hindered by soil continuous cropping obstacles.
Methods
In this study, we investigated the potential of differential fertilizer application, specifically the combination of homemade humic acid organic fertilizer, compound fertilizer, and Bacillus subtilis, in improving soil conditions and microbial activity to alleviate the soil continuous cropping obstacles in chili pepper cultivation. The experiment focused on evaluating the effects of the differential fertilizer application on soil physicochemical properties, including electrical conductivity and enzyme activities (urease, hydrogen peroxide, phosphatase, and sucrase), as well as cation exchange capacity. Additionally, the microbial community in the soil was also examined.
Results
The application of the differential fertilizer significantly improved soil conditions. The electrical conductivity was reduced, indicating a decrease in soil salinity. Enzyme activities, such as urease, hydrogen peroxide, phosphatase, and sucrase, exhibited increased levels, suggesting enhanced nutrient cycling and availability. Moreover, the cation exchange capacity was unaffected by the differential fertilizer application. Microbial analysis revealed positive changes in the soil microbial community, indicating a potential improvement in soil health.
Conclusions
These findings highlight the effectiveness of the differential fertilizer application, consisting of homemade humic acid organic fertilizer, compound fertilizer, and Bacillus subtilis, in mitigating soil continuous cropping obstacles in chili pepper cultivation. The improved soil conditions and enhanced microbial activity contribute to the sustainability and productivity of chili pepper production.
Online monitoring and prediction for surface roughness in rotational electro-magnetic finishing using acoustic emission and vision-based neural network
Authors: Lee Jung-Hee , Farson Dave , Cho Hideo , Kwak Jae-Seob 
Published: August 2023

Abstract
The importance of surface finishing processes and accurate surface quality prediction models has increased in response to the growing demand for improved surface finish for ultra-precision applications. To enhance process efficiency and develop accurate predictive models, numerous studies have investigated the monitoring and prediction of surface roughness. However, existing mathematical approaches encounter challenges in establishing the correlation between input and output variables and providing real-time surface status monitoring. Therefore, this study aimed to monitor and predict surface roughness in real-time for the rotational electro-magnetic finishing (REMF) process using acoustic emission (AE) signals. To analyze signal features and develop an accurate surface prediction model, a convolutional neural network (CNN) was suggested, utilizing scalogram images as time-frequency characteristics of AE signals. The suggested model demonstrated outstanding quantitative results compared to those of the regression model, with training coefficient of determination (R2), mean squared error(MSE), and F-test of 0.986, 0.1910-3, and 99%, and testing R2, MSE, and F-test of 0.951, 2.2310-3, and 99%, respectively. In addition, the suggested model showed good generalization ability with a relatively lower mean MSE of 0.003 through verification experiments. These results demonstrated that the sensory data and image-driven model were effective in real-time monitoring and surface roughness prediction in the REMF process with high accuracy and reliability.
The Prevalence of Ageism in the Chinese Workplace: Investigating the Impact of the "Retirement" Age at 35 Years Old on Job Seekers
Authors: LI ZHENZHEN , Tang Zhihao 
Published: August 2023

Abstract

BackgroundThis study explores age discrimination's profound impact on job seekers aged 35+ in China. Despite their experience, they encounter unfair treatment and missed opportunities due to their age, resulting in stress and diminished mental well-being. This bias further erodes the motivation of experienced workers, ultimately hampering the efficiency of companies. The Chinese government's 35-year age limit for certain roles fuels ageism, reinforcing biased stereotypes.MethodsThis study investigates the influence of age discrimination on HR choices by employing mediators: perceived stereotypes (PS) and perceived age bias (PAB). The connections between these variables are analyzed using structural equation modeling (SEM), revealing the intricate impact of ageism on the dynamics of decision-making.ResultsThe findings of this study reveal pivotal insights. Age discrimination exerts a significant influence on mental well-being (MWB) and shapes prejudiced hiring choices. Perceived stereotypes (PS) strongly impact recruitment decisions (DTH), alongside perceived age bias (PAB). Notably, these relationships exhibit substantial statistical significance (p < 0.01), some demonstrating even higher significance (p < 0.001). What is more, gender moderates these effects, shedding light on nuanced dynamics within age bias effects.ConclusionThis inquiry uncovers harmful effects of age bias on job seekers aged 35+ in China. The unfair treatment arising from age-related factors generates stress, affecting mental well-being. Ageism permeates into the realm of hiring decisions, where stereotypes and bias wield influence over the choices made. The findings underscore the urgency of addressing age discrimination's repercussions on both individual well-being and organizational efficiency. The research enhances understanding of ageism's effects on individuals and workplaces in China.
Ensuring Secure and Efficient Multi-Cloud Storage with Brotli Compression and Hierarchical Data Protection
Authors: M. Antony Joans Kumar , C Christopher Columbus , E Ben George , C Seldev Christopher 
Published: August 2023

Abstract
Modern computing now relies on cloud storage as an essential component for providing a flexible and cost-effective solution for data storage and retrieval. However, ensuring the security and confidentiality of sensitive data in a cloud environment remains challenging. This paper advocates a secure multi-cloud storage solution termed as Brotli Compression based Hierarchical Data Protection. . This architecture enforces the required security by subjecting any file to be stored or retrieved from cloud storage through four hierarchical operations. The Brotli compression algorithm is employed to reduce the data size and enable faster transmission. Additionally, the Simple Regenerating Code encoding is applied for data reconstruction in case of data loss. To ensure data integrity, the system uses the MD5 hash function to generate a unique hash code which is appended with each chunk. The Circular Shift Chunk Allocation algorithm is used to select the chunk storage order across many clouds. The four levels of operations carried out backwards to retrieve the file. The performance of the proposed system is evaluated with other secure cloud storage systems already in existence. The results of the experiments outperformed other systems in terms of data retrieval time, transmission speed, and provides data security and confidentiality.
On the origin of initial hydrocarbons in methanol-to-hydrocarbons reaction
Authors: Ruiz-Martinez Javier , Li Teng , Chung Sang-Ho , Nastase Stefan , Wu Xiangkun , Zhang Zihao , Rushana Khairova , Bodi Andras , Hemberger Patrick , Gascon Jorge , Cavallo Luigi 
Published: August 2023

Abstract
Providing a complete scheme to describe the methanol-to-hydrocarbons (MTH) reaction network is impeded by insufficient understanding of the chemistry occurring incipiently. Using a temperature-dependent reaction strategy, combined with operando photoelectron photoion coincidence (PEPICO) spectroscopic diagnosis of intermediate species and theory, we provide a comprehensive understanding on initial hydrocarbons formation, including the first C–C bond, olefins, and aromatics. Surface acetyl groups attached to zeolite and gaseous ethenone (ketene) contain the first C–C bonds. Their generation is associated with surface methoxy species (SMS) formed over Brønsted acid sites and formaldehyde. Ketene methylation by SMS followed by decarbonylation leads to the first olefins, ethylene and propylene. Prins reaction between formaldehyde and propylene results in butadiene, which subsequently reacts with propylene via Diels–Alder reaction to yield methylcyclohexene. Successive hydrogen transfer steps produce the first aromatic compound, toluene. These mechanistic insights will inspire targeted catalyst design and process optimization for MTH technology.
Modeling the COVID-19: A case study based on oil futures
Authors: Alghalith Moawia , Floros Christos , Daglis Theodoros , Gkillas Konstantinos 
Published: August 2023

Abstract

The COVID-19 pandemic necessitated the production of mathematical models that were able to explain and thoroughly study various aspects and features of the pandemic. In this work, we provide a well-stated mathematical model to explain and simulate the evolution of the COVID-19 pandemic. To test our models performance and validity , we utilize actual surveillance data from the pandemic, capturing the results of this empirical investigation. According to the results, our model is valid, since all estimates are statistically significant, and the coefficients explain the evolution of the pandemic. We also explore the presence of potential non-linear dependence between future oil prices and the number of confirmed COVID-19 cases simulated by our model.
Developing grains influence terminal senescence and heat stress response by regulating oxidative stress and defense in wheat flag leaves
Authors: Semwal Vimal Kumar , Khanna-Chopra Renu 
Published: August 2023

Abstract
Heat stress at grain development is a major threat for global wheat production systems. This study investigated the impact of high temperature stress on wheat cultivar HW2041 and its cytoplasmic male sterile (CMS) line during grain development and its effects on leaf senescence and antioxidant defense mechanisms. Late-sown wheat crops experienced extreme high temperature stress, resulting in a shorter grain growth duration compared to normal-sown crops. Heat stress accelerated leaf senescence, as indicated by a faster decline in green flag leaf area, chlorophyll, and protein content. However, the CMS line exhibited delayed senescence and maintained higher levels of these parameters under heat stress. Heat stress also induced oxidative stress, with increased levels of reactive oxygen species (ROS), lipid peroxidation, and protein oxidation. However, the CMS line displayed better antioxidant defense mechanisms, including higher activities of antioxidant enzymes, superoxide dismutase (SOD), catalase (CAT), ascorbate peroxidase (APX), peroxidase (POX) and increased levels of ascorbate (AsA) and glutathione (GSH). Moreover, the CMS line exhibited better defense mechanisms in the chloroplast and mitochondria compared to the fertile line, indicating their involvement in regulating senescence and stress responses. Our findings suggest that the CMS line possesses improved heat stress tolerance and a more efficient antioxidant defense system, contributing to delayed senescence and reduced oxidative damage. This study provides valuable insights into the effects of high temperature stress on wheat and highlights the importance of genetic variations in heat stress tolerance.
PKM2 Confers Purine Metabolic Advantage and Enhances Lenvatinib Resistance in Hepatocellular Carcinoma
Authors: Chen Lei , Wang Peng , Wang Hongyang , Zhao Yan , Wang Feifei , Zhu Yanjing , Xu Mingshuang , Zhang Ya-ni , Wang Kaiting , Wang Shan , Shen Siyun , Hu Ji 
Published: August 2023

Abstract
Acquired resistance largely impedes the clinical efficacy of lenvatinib in hepatocellular carcinoma (HCC). Despite the identification of several underlying drivers, the comprehensive mechanism underlying lenvatinib resistance remains largely unknown. In the present study, we establish a lenvatinib-resistant model (Len-R) in HCC patients-derived organoids to simulate the emergence of resistant tumors. We demonstrate that upregulation of PKM2 is a hallmark of Len-R and PKM2 directly contributes to lenvatinib resistance. We also identify that purine metabolic flux enriched in Len-R confers the resistance property to tumor cells in a PKM2-dependent manner. For the molecular mechanism, PKM2 interacts directly with SMAD4 and enhances its occupancy on the SMAD4 binding element (SBE) at DHFR promoter region. Consequently, upregulated DHFR enhances purine nucleotide pool to resist the effectiveness of lenvatinib on purine metabolism pathway. Clinically, upregulation of PKM2 together with DHFR is associated with lenvatinib resistance and worse outcome in HCC patients. In summary, our data suggest that PKM2-SMAD4-DHFR axis drives lenvatinib resistance in HCC by provoking de novo purine biosynthesis.
Excessive social media use during the rainstorm disaster: Exploring the effects of social media overload on anxiety
Authors: Li Kai , Li Dingxi 
Published: August 2023

Abstract
This paper studies the adverse effects and potential mechanisms of social media overload in a rainstorm environment. This paper takes the stressor-strain-outcome (SSO) as the theoretical basis to build a model, which mainly reflects social media overload (information overload, communication overload and social overload), social media fatigue and disaster anxiety. The partial least square structural equation modeling (PLS-SEM) method was used to collect 547 valid samples for the study. The final results show that social media fatigue is caused by social media overload, while disaster anxiety is formed by social media fatigue. Social media fatigue partially mediates communication overload and disaster anxiety. This study advances the literature on social media adverse effects research and SSO and provides practical implications to social media users and risk management departments.
Focused Ultrasound versus the Loop Electrosurgical Excision Procedure to Treat Women with Cervical High-grade Squamous Intraepithelial Lesions Under 40: A Retrospective Study
Authors: Xiao Linlin , Dong Xu , Sun Jiangchuan , Zhang Xuerui , Feng Qing , Chang Shufang 
Published: August 2023

Abstract
Background
To evaluate whether focused ultrasound (FUS) or the loop electrosurgical excision procedure (LEEP) is a more feasible treatment for cervical high-grade squamous intraepithelial lesions (HSILs) among women of reproductive age.
Methods
Retrospective case record review of patients under 40 years treated for cervical HSIL using either FUS or LEEP from 1 September 2020 to 31 May 2022. Patients were followed up for cure, recurrence, human papillomavirus (HPV) clearance, and complications within 1 year following treatment. Odds ratios and 95% confidence intervals for no evidence of disease or HPV clearance associated with the treatment modalities and other covariates were estimated using univariate and multivariate logistic regression models.
Results
Among 1054 women who underwent FUS or LEEP, 225 met our selection criteria, of which 101 and 124 received FUS and LEEP, respectively. No significant difference was found in the cure rate during the 3–6-months follow-up (89.11% vs. 94.35%, P = 0.085), nor was there any such difference in the recurrence rate during the 6–12-months follow-up (2.22% vs. 1.71%, P = 0.790) between the two therapies. Both groups showed increasing cumulative HPV clearance rates over time without statistically significant differences (74.23% vs. 82.79%; P = 0.122, during the 3–6-months follow-up, and 84.95% vs. 89.17%; P = 0.359, during the 6–12-months follow-up). Furthermore, the incidence of complications caused by the two techniques was found to be similar. (5.0% vs. 5.6%, P = 0.818).
Conclusion
We found a similarity in effectiveness, safety and reliability between FUS and LEEP in treating women with HSIL under 40.
A prospective phase II randomized study of docetaxel combined with lobaplatin versus TPF regimen induction chemotherapy sequential concurrent chemoradiation for locally advanced head and neck squamous cell carcinoma
Authors: Zhang Mang , Wang Ziqi , Wu Weili , Jin Feng , Li Yuanyuan , Long Jinhua , Luo Xiuling , Gong Xiuyun , Chen Xiaoxiao , Liu Lina , Tang Hong , Chen Yu 
Published: August 2023

Abstract
Purpose: To compare the clinical effects of induction chemotherapy with TL (docetaxel plus lobaplatin) regimen with concurrent chemotherapy and TPF (docetaxel + cisplatin + 5-fluorouracil) regimen induction chemotherapy with concurrent chemotherapy of locally advanced head and neck squamous carcinoma.
Methods：128 patients with locally advanced HNSCC admitted to our department from August 2016 to April 2021 were randomly divided into trial group and control group, all using the hourly administration mode. The trial group used TL regimen induction chemotherapy combined with lobaplatin concurrent chemochemotherapy; the control group used TPF regimen induction chemotherapy and cisplatin concurrent chemotherapy. The endpoints were adverse events and survival rates at 1,3 and 5 years.
Results：Median follow-up time was 42 months (20 to 71 months).(1) adverse events: During induction chemotherapy, grade 3-4 leukocytes and neutrophils, diarrhea, 1-2 hyperbilirubinemia, nausea / vomiting, oral mucositis, fatigue, anorexia, hyponatremia were significantly lower (p<0. 05), 6%vs. 35%, 14%vs. 53%, 0% vs. 6%, 15%vs. 40%, 9%vs.56%, 0%vs.10%, 3%vs.13%, 2%vs.23%, 15%vs.74%. During chemoratreiation, the incidence of hyponatremia, hypokalaemia and grade 1-2 nausea was significantly lower in the TL group (p<0. 05), with 24%vs. 69%, 20%vs. 65%, and 24%vs. 44%, respectively.(2) There was no significant difference in the recent objective response rate (ORR) between patients with TL group and TPF group (p=0.961).(3) There was no statistical difference in 1-year, 3-year and 5-year OS between TL group and TPF group, Respectively, (71.0%vs.67.5%, p=0.573), (56.6%vs.56.9%, p=0.814), (52.5%vs.52.9%, p=0.841); 1-year PFS、3-year and 5-year PFS are: (63.4%vs. 64.0%, p=0.883), (51.1%vs.54.0%, P=0.705) and (47.3%vs.45.9%，p=0.887), None of them were significantly different. Multivariate analysis of COX regression showed that T stage (p=0.01) and surgery (p=0.046) were independent factors affecting PFS and OS, respectively. Subgroup analysis showed that the patients receiving the postoperative, N1 and N2 TL regimen tended to survive longer than the patients receiving the TPF regimen, and whether there was a significant interaction between the surgical subgroup and each subgroup.
Conclusion: For patients with locally advanced head and neck squamous cell carcinoma surgery and N stage N1 and N2, choosing TL group therapy may have more significant clinical benefits;In addition, TL regimen has advantages in reducing toxic side effects and can be considered as one of the first-line treatment options.
Trial registration: ClinicalTrials.gov (No. NCT03117257).
Development of novel Nd 2 O 3 doped Ag nanocomposite for the catalytic degradation of methylene blue and biological studies
Authors: Menazea Abdelrhman A. , El-Morsy M. A. 
Published: August 2023

Abstract

Our study focuses on optical behavior, methylene blue (MB) dye degradation potential of pure Neodymium oxide (Nd2O3 NPs), and Silver (Ag)/Neodymium oxide (Nd2O3) nano-composite, besides demonstrating their antibacterial performance in the resolve of silver and trioxide mineral interaction with different types of bacterial species. For illustration, S.aureus, and E.Coli give a significant response with clear enlargement of inhibition zone under Ag NPs adding. S.aureus inhibition area widened from 9.3 ± 0.5 mm for pure Neodymium oxide (Nd2O3) to 16.7 ± 0.4 mm for Ag/Nd2O3 nano-composite, while Escherichia coli inhibition zones jumped from 8.8 ± 0.4 mm for Neodymium oxide to15.9 ± 0.3 mm for Ag/ Nd2O3. Additionally, generally optical behavior shows clear band-gap narrowing with merging Ag NPs, which enhances boosting electronic localization. That direct and direct transitions dropped from (6.7 to 6.1) and (5.2 to 2.9 e.V), respectively. Regarding the MB degradation, Mixed System Ag/ Nd2O3 shows more efficient Methylene blue degradation than pure Nd2O3 in that the MB concentration fell to almost half of its starting point at 150 minutes, while pure Nd2O3 reached 33% after 150 minutes. Moreover, TEM displays the studied compositions microstructures confirming the good distribution of Ag NPs (average size 9.2 nm) upon Nd2O3. The results interpretations boost usage of such composites in sensors industries, and water treatment.