bluuebunny/crossref_metadata_2025_split huggingface dataset:
Views of physiotherapists on factors that play a role in ethical decision-making: an international online survey study
Authors: Sturm Andrea , Roth Roswith , Ager Amanda Louise 
Published: February 2023

AbstractBackgroundThere is a lack of knowledge about the ways physiotherapists around the world learn about professional code of ethics and ethical decision-making frameworks. The profession has a gap in the understanding about physiotherapists’ views on factors that play a role in ethical decision-making and whether these views differ between World Physiotherapy regions.MethodsAn online survey study in English was conducted from October 2018 to October 2019. Participants included 559 physiotherapists located in 72 countries. The self-designed survey questionnaire contained 13 items asking about demographic information and means of learning about ethical codes and decision-making frameworks. A further 30 items were presented which included statements underpinned with individual, organisational, situational and societal factors influencing ethical decision-making. Participants were asked to express their level of agreement or disagreement using a 5-point-Likert-scale.ResultsParticipants’ highest rated responses endorsed that the professional role of physiotherapists is linked to social expectations of ethical behaviour and that ethical decision-making requires more skills than simply following a code of ethics. A recognisable organisational ethical culture was rated as supporting good ethical decisions. Comparing responses by World Physiotherapy regions showed significant differences in factors such as culture, religion, emotions, organisational values, significant others, consequences of professional misconduct and professional obligations. Entry level education was not perceived to provide a solid base for ethical decision-making in every World Physiotherapy region. Participants reported multiple sources for learning about a professional code of ethics and ethical decision-making frameworks. What’s more, the number of sources differed between World Physiotherapy regions.ConclusionsMultiple factors play a role in physiotherapists’ ethical decision-making internationally. Physiotherapists’ ethical knowledge is informed by, and acquired from, several learning sources, which differ in both quality and quantity amongst World Physiotherapy regions. Easily accessible knowledge and education about professional codes of ethics and ethical decision-making can foster continuing professional development for physiotherapists. The establishment of constructive ethical cultures in workplaces can improve ethical decision-making, and should acknowledge the influence of individual, organisational, situational and societal factors. The establishment of collaborative learning environments can support knowledge translation which acknowledges practice-based methods of knowing and learning.
Development of a risk model based on autophagy-related genes to predict survival and immunotherapy response in ovarian cancer
Authors: Chen Yuwei , Deng Zhibo , Sun Yang 
Published: February 2023

Abstract
Background
Autophagy is a highly conserved cellular proteolytic process that can interact with innate immune signaling pathways to affect the growth of tumor cells. However, the regulatory mechanism of autophagy in the tumor microenvironment, drug sensitivity, and immunotherapy is still unclear.

Methods
Based on the prognostic autophagy-related genes, we used the unsupervised clustering method to divide 866 ovarian cancer samples into two regulatory patterns. According to the phenotypic regulation pattern formed by the differential gene between the two regulation patterns, a risk model was constructed to quantify patients with ovarian cancer. Then, we systematically analyzed the relationship between the risk model and immune cell infiltration, immunotherapeutic response, and drug sensitivity.

Results
Based on autophagy-related genes, we found two autophagy regulation patterns, and confirmed that there were differences in prognosis and immune cell infiltration between them. Subsequently, we constructed a risk model, which was divided into a high-risk group and a low-risk group. We found that the high-risk group had a worse prognosis, and the main infiltrating immune cells were adaptive immune cells, such as Th2 cells, Tgd cells, eosinophils cells, and lymph vessels cells. The low-risk group had a better prognosis, and the most infiltrated immune cells were innate immune cells, such as aDC cells, NK CD56dim cells, and NK CD56bright cells. Furthermore, we found that the risk model could predict chemosensitivity and immunotherapy response, suggesting that the risk model may help to formulate personalized treatment plans for patients.

Conclusions
Our study comprehensively analyzed the prognostic potential of autophagy-related risk models in ovarian cancer and determined their clinical guiding role in targeted therapy and immunotherapy.
Successful treatment with rituximab and plasmapheresis of renal involvement of eosinophilic granulomatosis with polyangiitis
Authors: Yoshii Ryuichi , Kajiwara Kengo , Uemura Naomichi , Matsushita Koki , Nakamura Tomohumi , Tomita Masao , Mukoyama Masashi 
Published: February 2023

Abstract
Background
Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare disorder characterized by asthma, eosinophilia, and systemic vasculitis. Renal involvement is not regarded as a prominent feature and the treatment is still under study.

Case presentation
A 68-year-old woman was admitted to our hospital because of fever, renal dysfunction, eosinophilia, and the presence of MPO-ANCA. Based on the renal pathological examination which showed extravascular eosinophilic-predominant inflammation and crescentic glomerulonephritis, EGPA was diagnosed. Considering the acute kidney injury, prominent eosinophilia, and strongly positive anti-MPO antibodies, pulse steroid therapy was administered, followed by intravenous rituximab. Plasmapheresis was also provided (9 sessions). The eosinophil count was normalized, and renal dysfunction was reversed. The patient no longer requires dialysis.

Conclusions
Renal involvement of EGPA is rare, and consensus on its treatment is still lacking, because of a lack of large-scale randomized controlled trials. We treated our patient as a case with high severity. For patients with severe disease, the addition of cyclophosphamide to glucocorticoid therapy is commonly used. However, rituximab and plasmapheresis combined with systemic glucocorticoid therapy were found to be beneficial because the renal function and other clinical conditions were almost fully recovered. Thus, our treatment is highly effective against renal involvement of eosinophilic granulomatosis with polyangiitis.
Organization of self-advantageous niche by neural stem/progenitor cells during development via autocrine VEGF-A under hypoxia
Authors: Kashiwagi Taichi , Takazawa Yuuki , Kagawa Tetsushi , Taga Tetsuya 
Published: February 2023

Abstract
Background
Tissue stem cells are confined within a special microenvironment called niche. Stem cells in such a niche are supplied with nutrients and contacted by other cells to maintain their characters and also to keep or expand their population size. Besides, oxygen concentration is a key factor for stem cell niche. Adult neural stem/progenitor cells (NSPCs) are known to reside in a hypoxic niche. Oxygen concentration levels are lower in fetal organs including brain than maternal organs. However, how fetal NSPCs adapt to the hypoxic environment during brain development, particularly before pial and periventricular vessels start to invade the telencephalon, has not fully been elucidated.

Methods
NSPCs were prepared from cerebral cortices of embryonic day (E) 11.5 or E14.5 mouse embryos and were enriched by 4-day incubation with FGF2. To evaluate NSPC numbers, neurosphere formation assay was performed. Sparsely plated NSPCs were cultured to form neurospheres under the hypoxic (1% O2) or normoxic condition. VEGF-A secreted from NSPCs in the culture medium was measured by ELISA. VEGF-A expression and Hif-1a in the developing brain was investigated by in situ hybridization and immunohistochemistry.

Results
Here we show that neurosphere formation of embryonic NSPCs is dramatically increased under hypoxia compared to normoxia. Vegf-A gene expression and its protein secretion were both up-regulated in the NSPCs under hypoxia. Either recombinant VEGF-A or conditioned medium of the hypoxic NSPC culture enhanced the neurosphere forming ability of normoxic NSPCs, which was attenuated by a VEGF-A signaling inhibitor. Furthermore, in the developing brain, VEGF-A was strongly expressed in the VZ where NSPCs are confined.

Conclusions
We show that NSPCs secret VEGF-A in an autocrine fashion to efficiently maintain themselves under hypoxic developmental environment. Our results suggest that NSPCs have adaptive potential to respond to hypoxia to organize self-advantageous niche involving VEGF-A when the vascular system is immature.
Anatomical approach to submental intubation through a paramedian transcrevicular approach
Authors: Kudva Adarsh , Saha Mehul , A Chithra , MV Eeshwar , Roy Sreea 
Published: February 2023

AbstractSubmental intubation has been established as a useful technique in securing the airway and is also less invasive as compared to a tracheostomy. This approach is especially useful in cases of fractures involving the naso-orbito-ethmoid complex, where a nasotracheal intubation would be contraindicated. Also, in case of orthognathic surgeries, where occlusion is considered to be the key to success, an orotracheal intubation could hinder the surgical procedure. In this technical note, we have described a modified submental intubation technique that is less invasive and at the same time facilitates successful airway management, thus reducing postoperative complications.
Isolated unilateral absence of pulmonary artery- an unusual cause of hemoptysis: a case report
Authors: Khaladkar Sanjay Mhalasakant , Kumar Divyajat , Kapoor Reetika 
Published: February 2023

Abstract
Background
Isolated unilateral absence of one pulmonary artery (IUAPA) is a rare malformation and a rare cause of hemoptysis. It occurs due to malformation of the sixth aortic arch during embryogenesis. This condition has variable presentations like dyspnoea, reduced exercise tolerance, chest pain, pleural effusion, recurrent bronchopneumonia, pulmonary hypertension, and haemoptysis can be asymptomatic.

Case Presentation
We describe a case of a 34-year-old female presenting with recent onset hemoptysis associated with mild dyspnoea and cough. Chest Radiograph revealed unilateral hyperlucent lung field which was later diagnosed as Isolated unilateral absence of pulmonary artery on high resolution computed tomography of chest with angiography.

Conclusion
Absent pulmonary artery should be considered as an important differential in cases presenting with hemoptysis. This case emphasises the significance of combining computed tomography with pulmonary angiography to accurately evaluate and define congenital lung abnormalities.
Visualisation of proteome-wide ordered protein abundances in Trypanosoma brucei
Authors: Tinti Michele , Ferguson Michael A. J. 
Published: February 2023

Background: Trypanosoma brucei is a protozoan parasite and etiological agent of human and animal African trypanosomiasis. It has a complex life cycle, but the most studied cellular types are the in vitro cultivated bloodstream- and procyclic-forms. These correspond to the replicating, mammalian host bloodstream-dwelling, slender trypomastigotes and tsetse vector midgut-dwelling procyclic lifecycle stages, respectively. Several proteomics studies have reported the differential abundance of proteins between these in vitro cultivated cell types. However, there are no datasets providing protein abundance, from most to least abundant, within and between both cell types. Methods: We used MaxQuant software 1.6.10.4 to reprocess a recent large-scale proteomics experiment from our laboratory and extracted intensity-based quantifications of the bloodstream and procyclic form proteomes. Results: We created a web interface to visually explore protein abundances within and between the in vitro cultivated T. brucei bloodstream and procyclic form proteomes. Conclusions: The protein abundance visualization tool, searchable by protein name(s) and attribute(s), is likely to be useful to the trypanosome research community. It will allow users to contextualise their proteins of interest in terms of their abundances in the T. brucei bloodstream and procyclic form proteomes.
Iranian women's experiences of the episiotomy consent process: a qualitative study
Authors: Ghiasvand Malihe , Nahidi Fatemeh , Mobarakabadi Sedigheh Sedigh , Majd Hamid Alavi 
Published: February 2023

BackgroundKnowledge of the benefits and complications of interventions related to medical procedures, such as episiotomy, enables women to make informed decisions regarding these interventions. This study investigated women's experiences of the episiotomy consent process in Iran.MethodsThis qualitative study gathered data from 20 women through in-depth semi-structured interviews. The participants were selected from hospitals, health centers and gynecology clinics in Tehran. Content analysis was used to establish themes from the gathered data.ResultsThe participants' experiences showed that they felt that their needs were not met and that they were excluded from decision making regarding their birth.ConclusionsWomen were excluded from decision making and their unmet needs presented ethical challenges in the performance of episiotomy procedures. Neglecting women's expectations, inducing absolute trust in obstetricians or midwives and failing to obtain informed consent paved the way for forced episiotomies. Proper education and obtaining informed and voluntary consent may facilitate women's rights being respected.
A randomized controlled trial comparing two-year postoperative femoral and tibial migration of a new and an established cementless rotating platform total knee arthroplasty
Authors: Koster Lennard A. , Rassir Rachid , Kaptein Bart L. , Sierevelt Inger N. , Schager Marjolein , Nelissen Rob G. H. H. , Nolte Peter A. 
Published: February 2023

Aims The primary aim of this study was to compare the migration of the femoral and tibial components of the cementless rotating platform Attune and Low Contact Stress (LCS) total knee arthroplasty (TKA) designs, two years postoperatively, using radiostereometric analysis (RSA) in order to assess the risk of the development of aseptic loosening. A secondary aim was to compare clinical and patient-reported outcome measures (PROMs) between the designs. Methods A total of 61 TKAs were analyzed in this randomized clinical RSA trial. RSA examinations were performed one day and three, six, 12, and 24 months postoperatively. The maximal total point motion (MPTM), translations, and rotations of the components were analyzed. PROMs and clinical data were collected preoperatively and at six weeks and three, six, 12, and 24 months postoperatively. Linear mixed effect modelling was used for statistical analyses. Results The mean MTPM two years postoperatively (95% confidence interval (CI)) of the Attune femoral component (0.92 mm (0.75 to 1.11)) differed significantly from that of the LCS TKA (1.72 mm (1.47 to 2.00), p < 0.001). The Attune femoral component subsided, tilted (anteroposteriorly), and rotated (internal-external) significantly less. The mean tibial MTPM two years postoperatively did not differ significantly, being 1.11 mm (0.94 to 1.30) and 1.17 mm (0.99 to 1.36, p = 0.447) for the Attune and LCS components, respectively. The rate of migration in the second postoperative year was negligible for the femoral and tibial components of both designs. The mean pain-at-rest (numerical rating scale (NRS)-rest) in the Attune group was significantly less compared with that in the LCS group during the entire follow-up period. At three months postoperatively, the Knee injury and Osteoarthritis Outcome Physical Function Shortform score, the Oxford Knee Score, and the NRS-activity scores were significantly better in the Attune group. Conclusion The mean MTPM of the femoral components of the cementless rotating platform Attune was significantly less compared with that of the LCS design. This was reflected mainly in significantly less subsidence, posterior tilting, and internal rotation. The mean tibial MTPMs were not significantly different. During the second postoperative year, the components of both designs stabilized and low risks for the development of aseptic loosening are expected. Cite this article: Bone Joint J 2023;105-B(2):148–157.
Metamaterial-based octave-wide terahertz bandpass filters
Authors: Maleki Ali , Singh Avinash , Jaber Ahmed , Cui Wei , Xin Yongbao , Sullivan Brian T. , Boyd Robert W. , Ménard Jean-Michel 
Published: February 2023

We present octave-wide bandpass filters in the terahertz (THz) region based on bilayer-metamaterial (BLMM) structures. The passband region has a super-Gaussian shape with a maximum transmittance approaching 70% and a typical stopband rejection of 20 dB. The design is based on a metasurface consisting of a metallic square-hole array deposited on a transparent polymer, which is stacked on top of an identical metasurface with a subwavelength separation. The superimposed metasurface structures were designed using finite-difference time-domain (FDTD) simulations and fabricated using a photolithography process. Experimental characterization of these structures between 0.3 and 5.8 THz is performed with a time-domain THz spectroscopy system. Good agreement between experiment and simulation results is observed. We also demonstrated that two superimposed BLMM (2BLMM) devices increase the steepness of the roll-offs to more than 85 dB/octave and enable a superior stopband rejection approaching 40 dB while the maximum transmittance remains above 65%. This work paves the way toward new THz applications, including the detection of THz pulses centered at specific frequencies, and an enhanced time-resolved detection sensitivity toward molecular vibrations that are noise dominated by a strong, off-resonant, driving field.
Sarcoidosis of the Bile Duct
Authors: Alsayid Muhammad , Taftaf Ahmad , Harmouch Khaled M. , Alabkaa Anas , Pappas Sam G. , Singh Ajaypal 
Published: February 2023

ABSTRACT
Sarcoidosis is an inflammatory disease that affects multiple organs. The lungs are the most commonly involved organs. Although a large proportion of patients with sarcoidosis have liver involvement, bile duct involvement is rare. Here, we present a case of a 56-year-old African American patient presented with painless jaundice because of extrahepatic bile duct sarcoidosis. Our diagnostic approach using endoscopic cholangioscopy with targeted biopsies confirmed the diagnosis. Multiple bile duct stent exchanges were performed to manage the bile duct stricture in addition to medical therapy.
Сardiorespiratory relationships in people of young age depending on the composite composition of the body
Authors: Gorban V. V. , Svistun O. V. , Gorban E. V. 
Published: February 2023

BACKGROUND: The decisive importance of the sympathetic and parasympathetic nervous system in maintaining vegetative homeostasis requires the determination of sensitive non-invasive parameters of multidimensional outpatient monitoring of cardiorespiratory adaptation under various physiological and clinical conditions, taking into account the function of external respiration (FER), compound body composition and heart rate variability (HRV).AIM: To identify concomitant changes in HRV, HR and compound body composition in young people as markers of cardiorespiratory adaptation and rehabilitation.MATERIALS AND METHODS: On the basis of the Kuban State Medical University, a single-centre, interventional, cross-sectional, single-sample, comparative, uncontrolled study of a general group of young people in which respiratory parameters and parameters of the compound body composition were determined. Some individuals in this group additionally underwent Holter monitoring of the electrocardiogram (ECG) at short intervals.RESULTS: In young people, a change in the compound body composition with an increase in total fat mass, visceral and body fat is associated with a decrease in respiratory function (a decrease in the Tiffno index, a decrease in the maximum middle-expiratory flow — MMEF), manifested by a decrease in HRV (according to the TI indicator), the absence of an increase in the autonomic regulation circuit (according to SDNN indicator), a decrease in parasympathetic activity (in terms of rMSSD) and the absence of sympathetic activation (in terms of SDANN). Positive shifts in the form of an increase in trunk muscles, the total amount of water and a decrease in the total fat mass are accompanied by an increase in lung capacity, forced expiratory volume in the first second and a change in HRV with sympathetic (in terms of LF / HF, SDANN) and parasympathetic activation (in terms of rMSSD), an increase in HRV (in terms of TI) and an increase in the autonomic regulation circuit of the vegetative nervous system (in terms of SDNN).CONCLUSION: Accurate and rapid diagnostics of vegetative homeostasis requires a comprehensive correlative analysis of the parameters characterizing HRV in short recordings, the compound composition of the human body and respiratory function.
Raumordnerische Steuerungstypen der wohnbaulichen Siedlungsentwicklung in Deutschland. Eine bundesweite Analyse der eingesetzten Planungsinstrumente in allen deutschen Planungsregionen
Authors: Pehlke David 
Published: February 2023

The steering of the residential development on the regional level is one of the major tasks of regional planning. Nevertheless, no nationwide information is yet available on the implementation of the planning instruments in regional plans. Moreover, for potential steering types, only one approach on the level of the German federal states exists. To reduce this information deficit, a plan content analysis is used to determine which positive planning instruments were implemented in the state development plans and regional plans valid in 2017. The data basis for negative planning instruments is the spatial development plan monitor of the Federal Office for Building and Regional Planning (BBSR). With these data, a non-linear principal component analysis and a cluster analysis is carried out to identify specific steering types. As a result, six regional planning steering types of pre-use planning, quantitative control, settlement axes, positive planning location control, intra-municipal framework with extensive mono-functional open space protection and extensive location control through multifunctional open space protection can be identified. The different steering types are often spatially clustered, so that a significant influence of state planning requirements can be assumed.