bluuebunny/crossref_metadata_2025_split huggingface dataset:
Psychological and physiological correlates of stimulus discrimination in adults
Authors: Fitzgerald Jacklynn M. , Webb E. Kate , Sangha Susan 
Published: May 2023

AbstractThe discrimination of cues in the environment that signal danger (“fear cue”) is important for survival but depends critically on the discernment of such cues from ones that pose no threat (“safety cues”). In rodents, we previously demonstrated the underlying neurobiological mechanisms that support fear versus safety discrimination and documented that these mechanisms extend to the discrimination of reward as well. While learning about reward is equally important for survival, it remains an under‐studied area of research, particularly in human studies of conditional discrimination. In the present study, we translated our rodent task of fear reward and neutral discrimination (fear, reward, and neutral discrimination [FRND]) for use in humans. Undergraduate students (N = 53) completed the FRND while electrodermal activity was recorded. Skin conductance response (SCR) amplitude, a marker of arousal response, was derived for fear, reward, and neutral cues that signaled no outcome; critical trials assessed conditional discrimination using combined fear + neutral and reward + neutral cues. Participants provided likeability ratings for each cue type. Results demonstrated that participants rated reward cues the best, fear cues the worst, and neutral cues in between, while SCR amplitude was largest for fear and reward cues and lowest for neutral cues. SCR amplitudes were reduced for fear + neutral (compared to fear) and reward + neutral cues (compared to reward). Results demonstrate that the FRND is a useful paradigm for the assessment of psychological and physiological discrimination of fear and reward. Implications and directions for future work are discussed.
Can a ground‐based vehicle hear the shape of a room?
Authors: Boutin Mireille , Kemper Gregor 
Published: May 2023

AbstractAssume that a ground‐based vehicle moves in a room with walls or other planar surfaces. Can the vehicle reconstruct the positions of the walls from the echoes of a single sound event? We assume that the vehicle carries some microphones and that a loudspeaker is either also mounted on the vehicle or placed at a fixed location in the room. We prove that the reconstruction is almost always possible if (1) no echoes are received from floors, ceilings, or sloping walls and the vehicle carries at least three noncollinear microphones, or if (2) walls of any inclination may occur, the loudspeaker is fixed in the room and there are four noncoplanar microphones. The difficulty lies in the echo‐matching problem: How to determine which echoes come from the same wall. We solve this by using a Cayley–Menger determinant. Our proofs use methods from computational commutative algebra.
Rhemata
Authors: Bellucci Francesco 
Published: May 2023

AbstractThe article offers an analysis of Peirce's notion of “rhema.” It examines and explains Peirce's definition of the rhema; it identifies and solves two problems that are direct consequences of the definition. The first problem is that proper names, while classified as rhemata, do not satisfy Peirce's definition of the rhema. The second problem is that Peirce also calls “rhemata” the results of propositional analysis that however do not satisfy his own definition of the rhema. Peirce himself solves the first problem by generalizing the notion of rhema into that of “seme.” I argue that we can solve the second problem if, following M. Dummett, we distinguish propositional analysis from propositional decomposition.
Bilateral simultaneous cataract surgery and intraocular lens implantation in an adult female chimpanzee (Pan troglodytes) inducing monovision
Authors: Notting F. , Cheng Y. , Marinkovic M. , van Bolhuis H. , Notting I. 
Published: May 2023

AbstractBackgroundCataract is the major cause of visual impairment in humans. Phacoemulsification with intraocular lens (IOL) implantation is the standard technique for cataract treatment with a high success rate. In a few cases, the surgical cataract procedure and lens implantation have been applied in non‐human primates.Case DescriptionA +/− 40‐year‐old female chimpanzee (Pan troglodytes) in captivity was diagnosed with mature cataract optical density (OD) and posterior subcapsular cataract combined with cortical opacities OS after ophthalmic examination. To restore vision and facilitate far‐ and near sight, phacoemulsification OU with +22.5 diopter (D) IOL implantation OD and + 24 D OS were performed. Despite complicated surgery OD due to posterior capsular rupture, the outcome was successful during 1‐year follow‐up. The chimpanzee regained adequate vision, normal behavior, and was successfully re‐introduced to her group of chimpanzees.ConclusionThis is the first case report of a simultaneous bilateral cataract surgery with IOL implantations in both eyes, targeting emmetropia OS and near vision OD resulting in monovision, in a chimpanzee. Vision was restored without postoperative complications.
Immune response after rabies pre‐exposure prophylaxis and a booster dose in Australian bat carers
Authors: Guo Yihan , Mills Deborah J. , Lau Colleen L. , Mills Christine , Furuya‐Kanamori Luis 
Published: May 2023

AbstractPeriodic vaccination against rabies is essential for individuals at continuing risk of rabies exposure. There is limited evidence on long‐term immunogenicity after a 3‐dose intramuscular (3IM) pre‐exposure prophylaxis (PrEP) and single IM booster dose, thus current guideline recommendations differ in the interval for serology tests following PrEP and boosters. This study investigated post‐PrEP and post‐booster persistence of antibodies in Australian bat carers. Bat carers who received 3IM PrEP/booster doses and had post‐PrEP/booster serology test results were included. The proportion of antibody‐negative (<0.5 EU/mL) individuals after PrEP/booster dose were examined. Three hundred and five participants (65.6% females, median age at PrEP 43.1 years) were included. The proportion who were antibody‐negative varied depending on the time between 3IM PrEP and the serology test: 8.0% <1 year, 29.8% 1–2 years, 21.2% 2–3 years and 7.7% >3 years. Ninety‐one participants receiving booster doses were further assessed. Only one participant was antibody‐negative at >3 years after receiving one IM booster dose. Our findings support that a serology test should be performed 1 year after 3IM PrEP, followed by first booster if required. Rabies antibodies persist for many years after receiving the booster doses. The interval between subsequent serology tests and the first booster dose should be no longer than 3 years. Future studies are required to provide more insight into the most appropriate timing of subsequent boosters.
Assessment of Newly-Designed Hybrid Nanofluid-Cooled Micro-Channeled Thermal Management System for Li-Ion Battery
Authors: Kumar Kartik , Sarkar Jahar , Mondal Swasti Sundar 
Published: May 2023

Abstract
Maintaining both maximum temperature and temperature uniformity within the desirable limit is a crucial issue for high C-rating Li-ion batteries of electric vehicles, which can be achieved by the properly designed battery thermal management system (BTMS). In this research, three new designs of liquid-cooled micro-channeled BTMS are suggested for cylindrical batteries to address the issue of temperature variations and uneven temperature distribution. Using 3D numerical simulation, we investigate the impacts of volume flowrate and the usage of mono/hybrid nanofluids with varying concentrations on the thermal performance of the battery pack at a high C-rate by utilizing a two-phase mixture model. Effects on maximum temperature, temperature uniformity, pumping power, and heat transfer coefficient to pressure drop ratio are investigated. Results demonstrate that the effectiveness of heat transmission and temperature uniformity of the battery pack are positively impacted by an increase in nanoparticle concentration in nanofluid and volume flow rate. Even at high C-rates (5 C), the proposed design can effectively reduce both cell temperature and thermal gradient of the 21700-type cylindrical cell. Design 3 is the most favorable BTMS for Li-ion cylindrical battery in terms of both maximum temperature and temperature uniformity (maximum temperature of 304.72 K and temperature difference of 4.7 K).
Deep Learning-Based Denoising of Acoustic Images Generated With Point Contact Method
Authors: Jadhav Suyog , Kuchibhotla Ravali , Agarwal Krishna , Habib Anowarul , Prasad Dilip K. 
Published: May 2023

Abstract
The versatile nature of ultrasound imaging finds applications in various fields. A point contact excitation and detection method is generally used for visualizing the acoustic waves in Lead Zirconate Titanate (PZT) ceramics. Such an excitation method with a delta pulse generates a broadband frequency spectrum and wide directional wave vector. The presence of noise in the ultrasonic signals severely degrades the resolution and image quality. Deep learning-based signal and image denoising have been demonstrated recently. This paper bench-marked and compared several state-of-the-art deep learning image denoising methods with the classical denoising methods. The best-performing deep learning models are observed to be performing at par or, in some cases, even better than the classical methods on ultrasonic images. We further demonstrate the effectiveness and versatility of the deep learning-based denoising model for the unexplored domain of ultrasound/ultrasonic data. We conclude with a discussion on selecting the best method for denoising ultrasonic images. The impact of this work may help ultrasound-based defects identification equipment manufacturers to adopt a deep learning-based denoising model for more wider and versatile use.
Comparison Between Cardiorespiratory Fitness and Functions of Cognitive Control in Adolescents: A Tracking Study of 3 Years
Authors: Weber Vinícius Muller Reis , Castro‐Piñero Jose , Cesar da Costa Julio , Fernandes Daniel Zanardini , Romanzini Marcelo , Ronque Enio Ricardo Vaz 
Published: May 2023

Purpose: Compare tracking groups with cognitive control functions and plasma brain-derived neurotrophic factors concentrations from childhood to adolescence. Methods: This is a prospective study with 3 years of follow-up. At baseline, data from 394 individuals were collected (11.7 y), and data were obtained from 134 adolescents (14.9 y) at the 3-year follow-up. At both time points, anthropometric and maximal oxygen uptake data were collected. Cardiorespiratory fitness (CRF) groups were classified into high or low CRF. At follow-up, cognitive outcomes were collected via the Stroop and Corsi block test; plasma brain-derived neurotrophic factors concentrations were also analyzed. Results: Comparisons demonstrated that maintaining high CRF over 3 years results in shorter reaction time, better inhibitory control, and higher working memory values. Likewise, the group that moved from low to high CRF over 3 years presented better reaction time. Plasma brain-derived neurotrophic factors concentrations were higher for the group that increased its CRF over the 3 years in relation to the low–low group (90.58 pg·mL−1; P = .004). However, after scaling by an allometric approach, differences were only found for reaction time and working memory between high–high and high–low groups. Conclusion: Maintaining high CRF over 3 years was positively related to reaction time and working memory in relation to adolescents that decreased their levels of CRF.
‘It’s just a finger isn’t it…’: patients’ perspectives of recovery following finger fractures and participation in surgical trials – a qualitative interview study
Authors: Mousoulis Christos , Karantana Alexia , Trickett Ryan W , Thomas Kim S , Leighton Paul 
Published: May 2023

ObjectivesTo (1) generate detailed, person-centred data about the experience of finger injury and treatment and (2) understand the patients’ perspectives of research involvement with a view to informing better designed future studies in hand injury.DesignQualitative study using semistructured interviews and framework analysis.Participants19 participants who were part of the Cohort study of Patients’ Outcomes for Finger Fractures and Joint Injuries study in a single secondary care centre in the UK.ResultsThe results of this study showed that although finger injuries are frequently seen as minor by patients and healthcare professionals, their effects on peoples’ lives are possibly greater than first anticipated. The relative importance of hand functioning means that the experience of treatment and recovery varies and is shaped by an individual’s age, job, lifestyle and hobbies. These factors will also inform an individual’s perspective on and willingness to participate in, hand research. Interviewees showed reluctance to accept randomisation in surgical trials. Interviewees would be more likely to participate in a study testing two variants of the same treatment modality (eg, surgery vs surgery), rather than two different modalities, (eg, surgery vs splint). The Patient-Reported Outcome Measure questionnaires that were used in this study were seen as less relevant by these patients. Pain, hand function and cosmetic appearance were considered important, meaningful outcomes.ConclusionsPatients with finger injuries need more support from healthcare professionals as they may experience more problems than first anticipated. Good communication by clinicians and empathy can help patients engage with the treatment pathway. Perceptions of an ‘insignificant’ injury and/or need for quick functional recovery will influence recruitment to future hand research (both positively and negatively). Accessible information about the functional and clinical consequences of a hand injury will be important in enabling participants to make fully informed decisions about participation.
Use of global rating scales and checklists in clinical simulation-based assessments: a protocol for a scoping review
Authors: Henrico Karien , Makkink Andrew William 
Published: May 2023

IntroductionAssessment in health sciences education remains a hotly debated topic, with measures of competency and how to determine them in simulation-based assessments enjoying much of the focus. Global rating scales (GRS) and checklists are widely used within simulation-based education but there is a question regarding how the two strategies are used within clinical simulation assessment. The aim of this proposed scoping review is to explore, map and summarise the nature, range and extent of published literature available relating to the use of GRS and checklists in clinical simulation-based assessment.MethodsWe will follow the methodological frameworks and updates described by Arksey and O’Malley, Levac, Colquhoun and O’Brien, and Peters, Marnie and Triccoet aland will report using the Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR). We will search PubMed, CINAHL, ERIC, Cochrane Library, Scopus, EBSCO, ScienceDirect, Web of Science, the DOAJ and several sources of grey literature. We will be including all identified sources published in English after 1 January 2010 that relate to the use of GRS and/or checklists in clinical simulation-based assessments. The planned search will be conducted from 6 February 2023 to 20 February 2023.Ethics and disseminationAn ethical waiver was received from a registered research ethics committee and findings will be disseminated through publications. The overview of literature the produced will help to identify knowledge gaps and inform future research on the use of GRS and checklists in clinical simulation-based assessments. This information will be valuable and useful for all stakeholders that are interested in clinical simulation-based assessments.
Global burden of cardiovascular disease attributable to metabolic risk factors, 1990–2019: an analysis of observational data from a 2019 Global Burden of Disease study
Authors: Wu Shuyi , Xu Wenlin , Guan Chengfu , Lv Meina , Jiang Shaojun , Jinhua Zhang 
Published: May 2023

ObjectivesAn up-to-date, detailed global analysis of the current status of the metabolic-attributed cardiovascular disease (CVD) burden has not been reported. Therefore, we investigated the global burden of metabolic-attributed CVD and its association with socioeconomic development status over the past 30 years.MethodsData on the burden of metabolic-attributed CVD were taken from the 2019 Global Burden of Disease (GBD) study. Metabolic risk factors of CVD included high fasting plasma glucose, high low-density lipoprotein cholesterol (LDL-c), high systolic blood pressure (SBP), high body mass index (BMI) and kidney dysfunction. Numbers and age-standardised rates (ASR) of disability-adjusted life-years (DALYs) and deaths were extracted and stratified by sex, age, Socio-demographic Index (SDI) level, country and region.ResultsThe ASR of metabolic-attributed CVD DALYs and deaths decreased by 28.0% (95% UI 23.8% to 32.5%) and 30.4% (95% UI 26.6% to 34.5%), respectively, from 1990 to 2019. The highest burden of metabolic-attributed total CVD and intracerebral haemorrhage was mainly in low SDI locations, while the highest burden of ischaemic heart disease and IS was mainly in high SDI locations. The burden of DALYs and deaths in CVD was higher in men than women. In addition, the number and ASR of DALYs and deaths were highest in those over 80 years old.ConclusionMetabolic-attributed CVD threatens public health, especially in low-SDI locations and among the elderly. Low SDI location should strengthen the control of metabolic factors such as high SBP, high BMI, and high LDL-c and increase the knowledge of metabolic risk factors for CVD. Countries and regions should enhance screening and prevention of metabolic risk factors of CVD in the elderly. Policy-makers should use 2019 GBD data to guide cost-effective interventions and resource allocation.
Temporal trends in cardiovascular risk factors, lifestyle and secondary preventive medication for patients with myocardial infarction attending cardiac rehabilitation in Sweden 2006–2019: a registry-based cohort study
Authors: Leosdottir Margret , Hagstrom Emil , Hadziosmanovic Nermin , Norhammar Anna , Lindahl Bertil , Hambraeus Kristina , Jernberg Tomas , Bäck Maria 
Published: May 2023

ObjectivesRegistries have been highlighted as means to improve quality of care. Here, we describe temporal trends in risk factors, lifestyle and preventive medication for patients after myocardial infarction (MI) registered in the quality registry Swedish Web-system for Enhancement and Development of Evidence-based care in Heart disease Evaluated According to Recommended Therapies (SWEDEHEART).DesignA registry-based cohort study.SettingAll coronary care units and cardiac rehabilitation (CR) centres in Sweden.ParticipantsPatients attending a CR visit at 1-year post-MI 2006–2019 were included (n=81 363, 18–74 years, 74.7% men).Outcome measuresOutcome measures at 1-year follow-up included blood pressure (BP) <140/90 mm Hg, low-density lipoprotein-cholesterol (LDL-C)<1.8 mmol/L, persistent smoking, overweight/obesity, central obesity, diabetes prevalence, inadequate physical activity, and prescription of secondary preventive medication. Descriptive statistics and testing for trends were applied.ResultsThe proportion of patients attaining the targets for BP<140/90 mmHg increased from 65.2% (2006) to 86.0% (2019), and LDL-C<1.8 mmol/L from 29.8% (2006) to 66.9% (2019, p<0.0001 both). While smoking at the time of MI decreased (32.0% to 26.5%, p<0.0001), persistent smoking at 1 year was unchanged (42.8% to 43.2%, p=0.672) as was the prevalence of overweight/obesity (71.9% to 72.9%, p=0.559). Central obesity (50.5% to 57.0%), diabetes (18.2% to 27.2%) and patients reporting inadequate levels of physical activity (57.0% to 61.5%) increased (p<0.0001 for all). From 2007, >90.0% of patients were prescribed statins and approximately 98% antiplatelet and/or anticoagulant therapy. Angiotensin-converting enzyme inhibitor/angiotensin receptor blocker prescription increased from 68.7% (2006) to 80.2% (2019, p<0.0001).ConclusionsWhile little change was observed for persistent smoking and overweight/obesity, large improvements were observed for LDL-C and BP target achievements and prescription of preventive medication for Swedish patients after MI 2006–2019. Compared with published results from patients with coronary artery disease in Europe during the same period, these improvements were considerably larger. Continuous auditing and open comparisons of CR outcomes might possibly explain some of the observed improvements and differences.
Point-of-care testing of HbA1c levels in community settings for people with established diabetes or people at risk of developing type 2 diabetes: a systematic review and meta-analysis protocol
Authors: Gourlay Anna , Sutherland Calum , Radley Andrew 
Published: May 2023

IntroductionDiabetes mellitus has increased in prevalence worldwide and is causing an increasing burden on health services. The best patient outcomes occur with early diagnosis to prevent health complications. Glycated haemoglobin (HbA1c) is used to assess glycaemic control over 3–6 months and inform clinical management. Point-of-care (POC) HbA1c devices can be used in community settings, independent of clinical laboratories. This review aims to evaluate how these devices have been implemented in community settings and what patient outcomes have been documented.Methods and analysisThis protocol follows the Preferred Reporting Items for Systematic Review and Meta-Analysis guidance. A systematic search was undertaken in October 2022, using the defined PICOS (population, intervention, comparison, outcomes, study type) statement to identify all relevant articles: CINAHL, Cochrane, PubMed, Scopus and Web of Science were searched (updated February 2023). Studies will be included if they report outcomes of community POC testing for HbA1c for people with diabetes or at risk of diabetes. We will review the PROSPERO database and trial registers.Title, abstract screening and full-text review will be carried out by two reviewers. The Cochrane risk-of-bias tool will be used to assess randomised studies and the National Institutes of Health (NIH) Quality Assessment tool for observational cohort and cross-sectional studies. Publication bias will be assessed visually with a funnel plot and statistical approaches if necessary. If a group of sufficiently comparable studies are identified, we will perform a meta-analysis applying a fixed or random effects model as appropriate. We will investigate heterogeneity using visual inspection of forest plots along with review of evaluative approaches such as Χ2and the I2statistic. Strength of evidence will be assessed using Grading of Recommendations, Assessment, Development and Evaluation.Ethics and disseminationEthics approval is not required for this literature review. The results will be disseminated through peer-reviewed publication and conference presentations. Furthermore, this systematic review will be used to inform the design of a community pharmacy-based prediabetes intervention.PROSPERO registration numberCRD42023383784.