bluuebunny/crossref_metadata_2025_split huggingface dataset:
Eisenstein cohomology classes for GL
N
over imaginary quadratic fields
Authors: Bergeron Nicolas , Charollois Pierre , García Luis E. 
Published: March 2023

Abstract
We study the arithmetic of degree

N
-
1

{N-1}

Eisenstein cohomology classes for the locally symmetric spaces attached to

GL
N

{\mathrm{GL}_{N}}

over an imaginary quadratic field k. Under natural conditions we evaluate these classes on

(

N
-
1

)

{(N-1)}

-cycles associated to degree N extensions

L
/
k

{L/k}

as linear combinations of generalized Dedekind sums. As a consequence we prove a remarkable conjecture of Sczech and Colmez expressing critical values of L-functions attached to Hecke characters of L as polynomials in Kronecker–Eisenstein series evaluated at torsion points on elliptic curves with complex multiplication by k. We recover in particular the algebraicity of these critical values.
Erfolgsdeterminanten agnotologischer Strategien im Wissensmanagement
Authors: Reiss Michael 
Published: March 2023

ZusammenfassungAgnotologische Strategien bezwecken mittels Desinformation, Hacking, Cyberangriffen, Propaganda, Betrug, Gaslighting, Nudging, Überflutung, Zensur, selektiver Geheimhaltung oder Zugriffsbarrieren zu den Wissensinfrastrukturen den Abbau von Wissen und das Disabling von Entscheidungen der jeweiligen Targets. Manipulatoren wollen bei den Targets eine irreführende, intransparente und/oder lückenhafte Wissensbasis schaffen. Der Manipulationserfolg hängt entscheidend vom Strategieverbund und von der Resilienz der Targets ab.
Dying in the Odor of Sanctity: Philip Neri and the Performance of Saintly Death in Catholic Reformation Rome
Authors: Santa Maria Thomas J. 
Published: March 2023

Abstract
For the four-hundredth anniversary of the canonization of Philip Neri, this paper proposes to analyze important elements of Neri’s sanctity. In particular, it focuses on what Oratorian hagiographers emphasized about his life and his holiness in their creation of his saintly reputation. I argue that death and dying was a central aspect of Philipine sanctity. In his life and ministries, modeling himself after Christian solitary ascetic monks and charitable caregiving mendicants, Philip Neri’s life revolved around death.
On the Canonization of the Founders of Religious Orders in Early Modern Times
Authors: Samerski Stefan 
Published: March 2023

Abstract
Neither before nor after the multiple canonization processes of 1622 have so many founders of religious orders been canonized at the same time. When examining in detail the historic processes of the founders, however, it is not generally possible to identify smooth and rapid procedures leading to their canonization. In the history of the Congregation of Rites, there were multiple hurdles and forms of resistance in the Congregation itself. The reason for the swift canonizations of 1622 was not in reality the founding of an order, but the ecclesiastical interests of the Pope and the Curia in highlighting the important protagonists of Catholic Reform. In addition, the new saints were associated with the struggle against heresies and the defence of the Apostolic See.
Once again on the evolution of the Anatolian hieroglyphic script
Authors: Yakubovich Ilya 
Published: March 2023

Abstract
The Anatolian hieroglyphic script represents a logosyllabic system, which gradually evolved in Asia Minor in the course of the second millennium BCE. Although the first syllabic values of Anatolian hieroglyphs are attested about 1400 BCE, there have been recent attempts to demonstrate that linguistic considerations prompt the projection of the development of the syllabic script further back in time. The present paper addresses the arguments advanced in favour of such a hypothesis and shows their inconclusive character. A collateral result of the present investigation is the segmentation of the set of earliest syllabic signs for which logographic readings are also attested. The comparison between the logographic and syllabic values within this set is conducive to a conclusion that the Hittite language, as opposed to Luwian, played a decisive role in assigning the syllabic values to Anatolian hieroglyphs in Hattusa between 1400 and 1250 BCE.
Rebus compositions in Linear A?
Authors: Montecchi Barbara 
Published: March 2023

Abstract
This paper deals with some Linear A logograms which might have been occasionally used not because of their meaning, but phonetically, on the basis of the sound of the words underlying the signs, to spell out different words, in rebus compositions with one or more syllabograms. This would be the case with the logogram for wine (AB 131a) on two clay tablets from Agia Triada (HT 14.1 and 123a.3), the logogram for human (A 100/102) on several clay documents from different sites (HT 72, KH Wc 2100, and PE Zb 7), and the logogram for olives (AB 122) on stone tables KO Za 1 and SY Za 2. The last two examples imply the reappraisal of the debate about the uncertain reading of one sign on KO Za 1 either as AB 27 or 122. In this paper it is shown how the latter is the only one supported by paleography.
Some observations on the language of Linear A
Authors: Monti Orazio 
Published: March 2023

Abstract
Examination of the Linear A texts confirms that
- the language of Linear A is probably only one (§ 1);
- the alternation a-/ja- in a-sa-sa-ra-me/ja-sa-sa-ra-me etc. is likely due to the presence of a prefix i/j- and not to a laryngeal or a graphic variant (§ 2);
- the sequence -i-*301- of a-ta-i-*301-wa-ja and variants is probably a verbal root (§§ 3-4);
- (j)a-sa-sa-ra-me probably means ‘gift, homage’ vel. sim. (but not necessarily ‘sacred’) and not ‘offering’ (§ 5);
- the prefix i/j- probably has the function of an article and i-na- could be its plural form (§ 6).
More generally, convincing arguments have already been put forward which strongly suggest that the language of Linear A is probably neither Indo-European nor Semitic (Afro-Asiatic), nor an ergative language such as Hurro-Urartian (§ 7).
A Lydian inscription from Denizli
Authors: Rojas Felipe , Öztürk Esengül Akıncı 
Published: March 2023

Abstract
A marble anthemion stele with a funerary inscription in Lydian was unearthed in 2010, during excavations led by Professor Kadir Pektaş at the Eski Mezarlık (or Old Cemetery) in the İlbadı neighbourhood of Denizli. The stone is currently in the Hierapolis Museum in Pamukkale. We present here a description of the stone and relief ornament, an edition of the Lydian text with commentary, a tentative partial translation, and a brief historical contextualization of the artifact. The text should be of interest to both Anatolianists and Indo-Europeanists, given its length and good state of preservation.
A novel autophagy-related long non-coding RNAs signature predicting progression-free interval and I-131 therapy benefits in papillary thyroid carcinoma
Authors: Hao Jie , Wang Shoujun , Wang Jinmiao , Zhang Zhendong , Gao Ming , Wan Yajuan 
Published: March 2023

Abstract
This study aimed to explore the prognostic and predictive value of autophagy-related lncRNAs in papillary thyroid carcinoma (PTC). The expression data of autophagy-related genes and lncRNAs of the PTC patients were obtained from TCGA database. Autophagy-related-differentially expressed lncRNAs (DElncs) were identified and used to establish the lncRNAs signature predicting patients’ progression-free interval (PFI) in the training cohort. Its performance was assessed in the training cohort, validation cohort, and entire cohort. Effects of the signature on I-131 therapy were also explored. We identified 199 autophagy-related-DElncs and constructed a novel six-lncRNAs signature was constructed based on these lncRNAs. This signature had a good predictive performance and was superior to TNM stages and previous clinical risk scores. I-131 therapy was found to be associated with favorable prognosis in patients with high-risk scores but not those with low-risk scores. Gene set enrichment analysis suggested that a series of hallmark gene sets were enriched in the high-risk subgroup. Single-cell RNA sequencing analysis suggested that the lncRNAs were mainly expressed in thyroid cells but not stromal cells. In conclusion, our study constructed a well-performed six-lncRNAs signature to predict PFI and I-131 therapy benefits in PTC.
Dealing with Migration at an Institutional Level: The Collective Securitization Actions of the European Union
Authors: Doğanyılmaz Duman Didem , Duman Gökhan , Oral Gül 
Published: March 2023

Abstract
Migration has been placed high on the agenda by the EU as being securitized related to policy changes as well as border security. Growing numbers of irregular migrants have paved the way for a systematic coordination and a consequent regional response in the region; therefore, dedicated security-based policies have been revised. This research analyzes the response that the EU put in action to the irregular migration due to the Arab Uprisings within the scope of collective securitization, and answers the question of why the EU has needed to respond to the demographic changes in the neighborhood as a supra-national securitizing actor. The empirical part of the research will be limited to the policy changes in the European Neighborhood Policy and the Schengen Agreement within the framework of institutional response between 2011 and 2015.
The effects of fine particulate matter on the blood-testis barrier and its potential mechanisms
Authors: Zheng Shaokai , Jiang Lianlian , Qiu Lianglin 
Published: March 2023

Abstract
With the rapid expansion of industrial scale, an increasing number of fine particulate matter (PM2.5) has bringing health concerns. Although exposure to PM2.5 has been clearly associated with male reproductive toxicity, the exact mechanisms are still unclear. Recent studies demonstrated that exposure to PM2.5 can disturb spermatogenesis through destroying the blood-testis barrier (BTB), consisting of different junction types, containing tight junctions (TJs), gap junctions (GJs), ectoplasmic specialization (ES) and desmosomes. The BTB is one of the tightest blood-tissue barriers among mammals, which isolating germ cells from hazardous substances and immune cell infiltration during spermatogenesis. Therefore, once the BTB is destroyed, hazardous substances and immune cells will enter seminiferous tubule and cause adversely reproductive effects. In addition, PM2.5 also has shown to cause cells and tissues injury via inducing autophagy, inflammation, sex hormones disorder, and oxidative stress. However, the exact mechanisms of the disruption of the BTB, induced by PM2.5, are still unclear. It is suggested that more research is required to identify the potential mechanisms. In this review, we aim to understand the adverse effects on the BTB after exposure to PM2.5 and explore its potential mechanisms, which provides novel insight into accounting for PM2.5-induced BTB injury.
Facilitation of Behavioral and Cortical Emergence from Isoflurane Anesthesia by GABAergic Neurons in Basal Forebrain
Authors: Cai Ping , Su Wei-Kun , Zhang Jin-Sheng , Liu Pei-Chang , Liu Feng , Liu Ren-Fu , Li Zhang-Shu , Zhu Zhong-Hua , Xiao Wen-Hao , Hu Yong-Huai , Cai Hong-Da , Wu Xiao-Dan , Zhang Liang-Cheng , Yu Changxi , Chen Li 
Published: March 2023

General anesthesia shares many similarities with natural sleep in behavior and electroencephalogram (EEG) patterns. The latest evidence suggests that general anesthesia and sleep–wake behavior may share overlapping neural substrates. The GABAergic neurons in the basal forebrain (BF) have recently been demonstrated to play a key role in controlling wakefulness. It was hypothesized that BF GABAergic neurons may participate in the regulation of general anesthesia. Here, usingin vivofiber photometry, we found that the activity of BF GABAergic neurons was generally inhibited during isoflurane anesthesia, having obviously decreased during the induction of anesthesia and being gradually restored during the emergence from anesthesia, in Vgat-Cre mice of both sexes. Activation of BF GABAergic neurons with chemogenetic and optogenetic approaches decreased sensitivity to isoflurane, delayed induction, and accelerated emergence from isoflurane anesthesia. Optogenetic activation of BF GABAergic neurons decreased EEG δ power and the burst suppression ratio (BSR) during 0.8% and 1.4% isoflurane anesthesia, respectively. Similar to the effects of activating BF GABAergic cell bodies, photostimulation of BF GABAergic terminals in the thalamic reticular nucleus (TRN) also strongly promoted cortical activation and behavioral emergence from isoflurane anesthesia. Collectively, these results showed that the GABAergic BF is a key neural substrate for general anesthesia regulation that facilitates behavioral and cortical emergence from general anesthesia via the GABAergic BF-TRN pathway. Our findings may provide a new target for attenuating the depth of anesthesia and accelerating emergence from general anesthesia.SIGNIFICANCE STATEMENTThe basal forebrain (BF) is a key brain region controlling sleep–wake behavior. Activation of GABAergic neurons in the BF potently promotes behavioral arousal and cortical activity. Recently, many sleep–wake-related brain structures have been reported to participate in the regulation of general anesthesia. However, it is still unclear what role BF GABAergic neurons play in general anesthesia. In this study, we aim to reveal the role of BF GABAergic neurons in behavioral and cortical emergence from isoflurane anesthesia and elucidate the underlying neural pathways. Understanding the specific role of BF GABAergic neurons in isoflurane anesthesia would improve our understanding of the mechanisms of general anesthesia and may provide a new strategy for accelerating emergence from general anesthesia.
Virtual (Zoom) Interactions Alter Conversational Behavior and Interbrain Coherence
Authors: Balters Stephanie , Miller Jonas G. , Li Rihui , Hawthorne Grace , Reiss Allan L. 
Published: March 2023

A growing number of social interactions are taking place virtually on videoconferencing platforms. Here, we explore potential effects of virtual interactions on observed behavior, subjective experience, and neural “single-brain” and “interbrain” activity via functional near-infrared spectroscopy neuroimaging. We scanned a total of 36 human dyads (72 participants, 36 males, 36 females) who engaged in three naturalistic tasks (i.e., problem-solving, creative-innovation, socio-emotional task) in either an in-person or virtual (Zoom) condition. We also coded cooperative behavior from audio recordings. We observed reduced conversational turn-taking behavior during the virtual condition. Given that conversational turn-taking was associated with other metrics of positive social interaction (e.g., subjective cooperation and task performance), this measure may be an indicator of prosocial interaction. In addition, we observed altered patterns of averaged and dynamic interbrain coherence in virtual interactions. Interbrain coherence patterns that were characteristic of the virtual condition were associated with reduced conversational turn-taking. These insights can inform the design and engineering of the next generation of videoconferencing technology.SIGNIFICANCE STATEMENTVideoconferencing has become an integral part of our lives. Whether this technology impacts behavior and neurobiology is not well understood. We explored potential effects of virtual interaction on social behavior, brain activity, and interbrain coupling. We found that virtual interactions were characterized by patterns of interbrain coupling that were negatively implicated in cooperation. Our findings are consistent with the perspective that videoconferencing technology adversely affects individuals and dyads during social interaction. As virtual interactions become even more necessary, improving the design of videoconferencing technology will be crucial for supporting effective communication.
Megahertz Sampling of Prestin (SLC26a5) Voltage-Sensor Charge Movements in Outer Hair Cell Membranes Reveals Ultrasonic Activity that May Support Electromotility and Cochlear Amplification
Authors: Santos-Sacchi Joseph , Bai Jun-Ping , Navaratnam Dhasakumar 
Published: March 2023

Charged moieties in the outer hair cell (OHC) membrane motor protein, prestin, are driven by transmembrane voltage to power OHC electromotility (eM) and cochlear amplification (CA), an enhancement of mammalian hearing. Consequently, the speed of prestin's conformational switching constrains its dynamic influence on micromechanics of the cell and the organ of Corti. Corresponding voltage-sensor charge movements in prestin, classically assessed as a voltage-dependent, nonlinear membrane capacitance (NLC), have been used to gauge its frequency response, but have been validly measured only out to 30 kHz. Thus, controversy exists concerning the effectiveness of eM in supporting CA at ultrasonic frequencies where some mammals can hear. Using megahertz sampling of guinea pig (either sex) prestin charge movements, we extend interrogations of NLC into the ultrasonic range (up to 120 kHz) and find an order of magnitude larger response at 80 kHz than previously predicted, indicating that an influence of eM at ultrasonic frequencies is likely, in line with recentin vivoresults (Levic et al., 2022). Given wider bandwidth interrogations, we also validate kinetic model predictions of prestin by directly observing its characteristic cut-off frequency under voltage-clamp as the intersection frequency (Fis), near 19 kHz, of the real and imaginary components of complex NLC (cNLC). The frequency response of prestin displacement current noise determined from either the Nyquist relation or stationary measures aligns with this cut-off. We conclude that voltage stimulation accurately assesses the spectral limits of prestin activity, and that voltage-dependent conformational switching is physiologically significant in the ultrasonic range.SIGNIFICANCE STATEMENTThe motor protein prestin powers outer hair cell (OHC) electromotility (eM) and cochlear amplification (CA), an enhancement of high-frequency mammalian hearing. The ability of prestin to work at very high frequencies depends on its membrane voltage-driven conformation switching. Using megahertz sampling, we extend measures of prestin charge movement into the ultrasonic range and find response magnitude at 80 kHz an order of magnitude larger than previously estimated, despite confirmation of previous low pass characteristic frequency cut-offs. The frequency response of prestin noise garnered by the admittance-based Nyquist relation or stationary noise measures confirms this characteristic cut-off frequency. Our data indicate that voltage perturbation provides accurate assessment of prestin performance indicating that it can support cochlear amplification into a higher frequency range than previously thought.
Treatment burden, adherence, and quality of life in children with daily GH treatment in France
Authors: Coutant Régis , Tauber Maithé , Demaret Béatrice , Henocque Robin , Brault Yves , Montestruc François , Chassany Olivier , Polak Michel , _ _ 
Published: March 2023

Objective
The objective of this study was to describe in a real-life setting the treatment burden and adherence and quality of life (QOL) of children treated with daily injections of growth hormone and their relationship with treatment duration.

Design
This non-interventional, multicenter, cross-sectional French study involved children aged 3–17 years treated with daily growth hormone injections.

Methods
Based on a recent validated dyad questionnaire, the mean overall life interference total score (100 = most interference) was described, with treatment adherence and QOL, using the Quality of Life of Short Stature Youth questionnaire (100 = best). All analyses were performed according to treatment duration prior to inclusion.

Results
Among the 275/277 analyzed children, 166 (60.4%) had only growth hormone deficiency (GHD). In the GHD group, the mean age was 11.7 ± 3.2 years; median treatment duration was 3.3 years (interquartile range 1.8–6.4). The mean overall life interference total score was 27.7 ± 20.7 (95% CI (24.2; 31.2)), with non-significant correlation with treatment duration (P = 0.1925). Treatment adherence was good (95.0% of children reported receiving >80% of planned injections over the last month); it slightly decreased with treatment duration (P = 0.0364). Children’s overall QOL was good (81.5 ± 16.6 and 77.6 ± 18.7 according to children and parents, respectively), but subscores of the coping and treatment impact domains were <50. Similar results were observed in all patients independently of the condition requiring treatment.

Conclusions
This real-life French cohort confirms the treatment burden of daily growth hormone injections, as previously reported in an interventional study.
Conserved H3K27me3-associated chromatin remodelling allows STRA8 but not MEIOSIN expression in mammalian germ cells
Authors: Ishihara Teruhito , Fenelon Jane C , Griffith Oliver W , Ishiguro Kei-ichiro , Renfree Marilyn B 
Published: March 2023

In brief
Apart from mice, meiosis initiation factors and their transcriptional regulation mechanisms are largely unknown in mammals. This study suggests that STRA8 and MEIOSIN are both meiosis initiation factors in mammals, but their transcription is epigenetically regulated differently from each other.

Abstract
In the mouse, the timing of meiosis onset differs between sexes due to the sex-specific regulation of the meiosis initiation factors, STRA8 and MEIOSIN. Before the initiation of meiotic prophase I, the Stra8 promoter loses suppressive histone-3-lysine-27 trimethylation (H3K27me3) in both sexes, suggesting that H3K27me3-associated chromatin remodelling may be responsible for activating STRA8 and its co-factor MEIOSIN. Here we examined MEIOSIN and STRA8 expression in a eutherian (the mouse), two marsupials (the grey short-tailed opossum and the tammar wallaby) and two monotremes (the platypus and the short-beaked echidna) to ask whether this pathway is conserved between all mammals. The conserved expression of both genes in all three mammalian groups and of MEIOSIN and STRA8 protein in therian mammals suggests that they are the meiosis initiation factors in all mammals. Analyses of published DNase-seq and chromatin-immunoprecipitation sequencing (ChIP-seq) data sets confirmed that H3K27me3-associated chromatin remodelling occurred at the STRA8, but not the MEIOSIN, promoter in therian mammals. Furthermore, culturing tammar ovaries with an inhibitor of H3K27me3 demethylation before meiotic prophase I affected STRA8 but not MEIOSIN transcriptional levels. Our data suggest that H3K27me3-associated chromatin remodelling is an ancestral mechanism that allows STRA8 expression in mammalian pre-meiotic germ cells.
Magnitude and Slip Scaling Relations for Fault-Based Seismic Hazard
Authors: Shaw Bruce E. 
Published: March 2023

ABSTRACTScaling relations play an important role in fault-based seismic hazard estimates. Scaling relations impact estimates of the sizes and rate for a given fault area. Here, we examine which relations are the most useful for these estimates and issues that arise. These include the depth of large event ruptures, transient deepening of seismicity following large events, difficulties in using classical continuum exponent fits, and the importance of large event asymptotics. A new analysis of land-based data calls into question nonspecific exponent fitting, which is a standard practice. We show a dependence on the lower and upper cut-off magnitudes in the data in the best-fitting slope parameter relating magnitude to log area with this approach. We show as well a dependence on assumed data uncertainties. These sensitivities make using this quite standard approach very problematic. Based on this evidence and other factors, we propose recommendations for the minimal branch sets, which preserve epistemic uncertainty for use in fault-based seismic hazard estimates.