bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perceptions of an educational intervention for family caregivers of palliative care patients
Authors: Arias-Rojas Mauricio , Carreño-Moreno Sonia , Carmona-Montoya Xiomara 
Published: July 2023

Background: Nursing interventions aimed at family caregivers of palliative cancer patients require not only an objective evaluation, but also subjective consideration of their contributions, and a qualitative evaluation that provides an in-depth understanding of these interventions. Aims: This study aimed to explore the perceptions that family caregivers of palliative cancer patients had of the nursing intervention, PalliActive Caregivers, in reducing the uncertainty associated with illness and improving the caregiver's quality of life. Methods: A qualitative approach with content analysis was used. Telephone interviews were conducted with 23 caregivers who participated in the intervention. Findings: Five themes emerged from the content analysis: consolidating physical care, adopting a positive attitude, strengthening the support available to the caregiver, strengthening spirituality and strengthening relationships. Conclusion: The themes showed a positive impact of the intervention on aspects such as the caregiver's ability to cope, spirituality and social support of caregivers. The results also indicated the possibility of conducting this type of study to identify other assessment variables for future interventions.
Yoga and the Healing of Interpersonal Trauma: A Qualitative Meta-Analysis
Authors: Ong Gaffney Isabelle , Gulden Ashley W. , Jennings Len , Page Mackenna L. 
Published: July 2023

Abstract
Although emerging research indicates that yoga facilitates healing from interpersonal trauma, consensus is lacking as to yoga’s main facilitative factors. To address this limitation, we employed qualitative meta-analysis to analyze data from six qualitative studies (n = 105) that examined the healing agents of yoga that facilitated recovery from interpersonal trauma. The analysis process included coding data from each study and analyzing codes across all of the studies to derive meta-categories. Three researchers engaged in dual-level analyses (i.e., both inductive and deductive) to support consistency, address any inconsistencies, and develop a consensus. We identified and categorized six meta-categories based on the original 45 themes from the six studies and found differing levels of convergence across the studies. Meta-categories with high levels of convergence included (1) stabilization: coping strategies to reduce trauma-related symptoms; (2) authenticity, inner attunement, and self-acceptance; (3) equanimity: calming the mind and mindfulness; and (4) community: reduced isolation through safe connection with others. Our findings offer a more integrated, comprehensive, and consolidated understanding of the specific ways yoga can facilitate recovery from interpersonal trauma and demonstrate how qualitative meta-analysis methodology can tie together the richness of similar, stand-alone qualitative studies.
Insig1 deletion in proximal tubular deregulates Aldh1a1 to consume NAD+ and contributes to renal fibrosis
Authors: Yu Xiaowen , Li Shumin , Qin Jun , Zhao Yingying , Wang Jiali 
Published: July 2023

AbstractProfibrotic proximal tubules (PTs) were identified as a unique phenotype of PTCs in renal fibrosis. Controlling the process of renal fibrosis requires understanding how to manage the S1 subset's branch to the S3 subset rather than to the profibrotic PT subset. Insig1 is one of the branch-dependent genes involved in controlling this process, although its role in renal fibrosis is unknown. Here, we discovered the pathogenic effect of PTC-specific Insig1 deficiency on renal fibrosis in vivo and in vitro. Overexpression of Insig1 profoundly inhibited renal fibrosis. Insig1 deletion boosted SREBP1 nuclear localization, increasing Aldh1a1 transcriptional activity, causing excessive NAD+consumption and ER enlargement, and accelerating renal fibrosis. We identified nicardipine as a selective inhibitor of Aldh1a1-restored NAD+and ER homeostasis, which attenuated renal fibrosis. Together, our findings support Insig1 as a new therapeutic target for CKD.
Numerical methods for geometric nonlinear elastic-plastic seismic responses time-history analysis of suspension bridges
Authors: Han Qinghua , Wu Chao , Liu Mingjie , Wu Hao 
Published: July 2023

Abstract
A reliable numerical method is proposed for the nonlinear inelastic dynamic analysis of suspension bridges subjected to earthquake excitations. It is also a general-purpose theory framework for nonlinear finite element analysis of large-scale structures. The proposed procedure includes both geometric and material nonlinearities. The geometric nonlinearities of cable members are captured by the catenary element derived from exact analytical expressions of elastic catenary, while the geometric nonlinearities of tower and girder members are predicted by the ameliorative nonlinear beam element which can undergo large deflections and large rotations. The material nonlinearities of tower and girder are considered by the improved distributed plasticity model whose state determination is based on an iterative scheme that satisfies internal equilibrium and compatibility. The large deformation of truss member is tracked by the rod element deduced from Euler angle decomposition of rigid body rotation. An incremental iterative solution based on Newmark time integration with Newton–Raphson iteration is adopted for solving the nonlinear equation of motion. The results are compared with those generated by OpenSees to illustrate the accuracy of proposed procedure.
Uniportal video-assisted thoracoscopic fissureless right upper lobe anterior segmentectomy for inflammatory myofibroblastic tumor
Authors: Ahn Seha , Lee Heejin , Choi Jung Suk , Choi Si Young , Kim In Sub , Kang Joon Kyu , Moon Youngkyu 
Published: July 2023

AbstractInflammatory myofibroblastic tumor is an exceptionally rare neoplasm with intermediate malignant potential. Surgery is the accepted mode of treatment, aiming for complete resection with clear margins. Herein, we describe a 39-year-old woman who underwent right upper lobe anterior segmentectomy of an asymptomatic pulmonary nodule by way of uniportal video-assisted thoracoscopy. A provisional tissue diagnosis of malignancy was later revised to inflammatory myofibroblastic tumor. Absence of a minor fissure between right upper and middle lobes called for an alternate approach to resection. We injected indocyanine green to clearly delineate the intersegmental plane. After an uneventful recovery, patient discharge was on postoperative Day 3. Annual chest tomography scans are planned to monitor for potential local recurrence. This particular case underscores the challenges in diagnosing and managing such tumors, showing the importance of accurate pathologic assessments and tailored surgical strategies.
Rizatriptan benzoate-loaded dissolving microneedle patch for management of acute migraine
Authors: Zhong Chao , Zhang Xiufeng , Shen Zhong , Sun Yanfang , Mao Yanan , Liu Tianqiu , Wang Rui , Nie Lei , Shavandi Amin , Yunusov Khaydar E. , Jiang Guohua 
Published: July 2023

AbstractIn this study, dissolving microneedles (MNs) using polyvinyl alcohol (PVA) and poly(1-vinylpyrrolidone-co-vinyl acetate) copolymers (PVP-VA) as the matrix has been developed for transdermal delivery of rizatriptan benzoate (RB) for acute migraine treatment.In-vitropermeation studies were conducted to assess the feasibility of fabricating dissolving MNs to release RB. Franz diffusion cell tests showed higher transdermal flux with dissolving MNs compared to passive diffusion. This was due to the MNs' mechanical strength, enabling them to penetrate the skin and form microchannels.The in vivo pharmacological study demonstrated that dissolving microneedles (MNs) loaded with RB effectively reduced migraine-related symptoms. This was achieved by increasing the level of 5-hydroxytryptamine (5-HT) and decreasing the levels of calcitonin gene-related peptide (CGRP) and substance P (SP).In conclusion, the RB-loaded dissolving MNs offer several advantages compared to conventional administrations methods, including safety, convenience, and high efficacy. These findings provide a promising basis for the development of transdermal drug delivery systems for the treatment of acute
Slow media – Slow comics. Komiks wobec przemian epoki cyfrowej w świetle idei wolnych mediów
Authors: Sęk-Iwanek Matylda 
Published: July 2023

W niniejszym artykule omówiono komiks w perspektywie idei slow media (wolnych mediów) i slow journalism (wolne dziennikarstwo). Przedstawiono, jakie cechy komiksów są właściwie dla wolnych mediów i jakimi tropami należy podążać, aby odnaleźć ślady idei slow. W studiach nad wolnymi mediami możemy wyodrębnić trzy najważniejsze obszary związane z: treścią (przekazem), produkcją (nadawcą) i konsumpcją (odbiorcą). Znaczące miejsce w tekście zajęły reportaże komiksowe. Krótko scharakteryzowano również polskie środowisko nadawców oraz odbiorców.
Analisis Dampak Ekonomi Dan Lingkungan Pada Kegiatan Destinasi Wisata Banten Lama
Authors: Wijayanto Candra , Adamullah Tubagus Alandaru 
Published: July 2023

Banten is an area located in the western part of the island of Java, Banten was once part of the province of West Java but after experiencing expansion from 2000, the center of government of Banten was moved which was located in the city of Serang, Banten in the past known as Bantam which is an area that has a busy port and open and prosperous residents' lives, the history of the establishment of Banten as a sultanate with the beginning of the early Sultan of Banten was Sultan Hasanuddin after that began to rule since 1552-1570 The Sultanate of Banten once experienced a peak of glory, especially during the reign of Sultan Ageng Tirtayasa, (1631-1692). Banten is not only the center of the spread of Islam, but the port of Banten is known as the most famous center of international trade, historically, the Banten Sultanate had faced the peak of glory, evidence of the glory of the Banten Sultanate can be traced through some literature. Meanwhile, the physical evidence that can be seen is the remains of past relics, such as the building site of the Surosowan Palace of the Banten Sultanate, objects stored in the Banten Antiquities Museum, and the Great Mosque of Banten. All relics are in the Banten Lama area, Kasemen District, Serang City, in this case, the research aims to determine the economic and environmental impacts of the influence of the existence of Banten tourist attractions, both positive and negative. The research method used is empirical law is a legal research method that uses empirical facts taken from human behavior, both verbal behaviors obtained from interviews or real behavior carried out through direct observation. The positive impact of increasing the income of the community around tourist destinations while on the negative side of the danger of dependence (overdependence) on the tourism industry, for positive environmental matters this can be seen with the tone of the management of Banten tourist attractions for a long time starting neatly arranged, but from a negative point of view there will be a lot of waste generated from tourists who come to visit tourist destinations and it can affect the environment.
Preparation and Characterization of Nay Zeolite for Biodiesel Production
Authors: Abbas Ammar S. , Abbas Rowaida N. 
Published: July 2023

Iraqi kaolin was used for the preparation and characterization of NaY zeolite for biodiesel production via esterification reaction. Oleic acid was used usually as a typical simulated feedstock of high acid number for the esterification reaction.
The chemical composition for the prepared Nay zeolite is as following: (Ca2.6Na1.K0.1)(Al6.3Si17.7)O48.16H2O, the silica to alumina ratio in the prepared catalyst was found equal to 2.6 and Na2O content was 12.26 wt. %, with relative crystallinity equal to 147.4 % obtained by the X-ray diffraction. The surface area result shows that the prepared catalyst has 330 m2/g. While, the measured pore volume by nitrogen adsorption was equal to 0.35 cm3/ g. SEM images show notable differences between the kaolin crystal and prepared NaY crystal.
The effect of NaY zeolite, as a loaded catalyst in the esterification of oleic acid reaction did not show any significant change of oleic acid conversion for catalyst load more than 5 wt. %. The reused NaY zeolite is loses 31 % of its activity because of that the pores are filled with water and other organic molecules and that may cause poisoning the catalyst.
A importância das pesquisas relacionadas aos desastres: colapso da barragem de Fundão Mariana-MG
Authors: Bandeira Otniel Alencar , Bandeira Palmeri Alencar 
Published: July 2023

A principal fonte de poluição ambiental são as atividades humanas que atingem o meio ambiente, esses poluentes se acumulam, alterando não só a característica do ar, da água e do solo, mas também causando danos à saúde humana e causando toxicidade aos organismos aquáticos. Dentre as atividades que causam poluição ambiental, destaca-se a mineração, que altera a qualidade do ecossistema e produz abundante quantidade de rejeitos que geralmente ficam na barragem. Quando essas barragens rompem, geram grandes problemas. Em novembro do dia 05 de 2015, na região de Mariana, em Minas Gerais, a mineradora brasileira sofreu seu pior acidente. A barragem da Samarco Mineradora rompeu e vazou cerca de 43 milhões de metros cúbicos de resíduos de mineração (argila e areia) ricos em ferro, alumínio, manganês e outros metais. A destruição da Barragem do Fundão causou desastre social, ambiental, cultural e econômico incomensuráveis em Mariana, no distrito de Bento Rodrigues e em outros 41 municípios, deixando um encalço de destruição ao longo do Rio Doce até chegar ao oceano. Várias pessoas encontrar-se desabrigadas, sem contar as que perderam a vida na tragédia, 19 pessoas. Os impactos dos ecossistêmicos causados ​​são inestimáveis e inconvertíveis. Tendo em vista as perguntas da população afetada, objetivo desta pesquisa extrair as lições do desastre para mostra a importância continuação dos estudos acadêmicos para contribuição e melhoria da sociedade afetada pelo desastre. Esta pesquisa trata de uma revisão de bibliografia. A revisão bibliográfica sistemática é um método científico para busca a análise de artigos de uma determinada área da ciência.
Modeling the tumor microenvironment of anaplastic thyroid cancer: an orthotopic tumor model in C57BL/6 mice
Authors: Xu Zhen , Shin Hyo Shik , Kim Yoo Hyung , Ha Seong Yun , Won Jae-Kyung , Kim Su-jin , Park Young Joo , Parangi Sareh , Cho Sun Wook , Lee Kyu Eun 
Published: July 2023

IntroductionSecuring a well-established mouse model is important in identifying and validating new therapeutic targets for immuno-oncology. The C57BL/6 mouse is one of the most fully characterised immune system of any animal and provides powerful platform for immuno-oncology discovery. An orthotopic tumor model has been established using TBP3743 (murine anaplastic thyroid cancer [ATC]) cells in B6129SF1 hybrid mice, this model has limited data on tumor immunology than C57BL/6 inbred mice. This study aimed to establish a novel orthotopic ATC model in C57BL/6 mice and characterize the tumor microenvironment focusing immunity in the model.MethodsAdapted TBP3743 cells were generated via in vivo serial passaging in C57BL/6 mice. Subsequently, the following orthotopic tumor models were established via intrathyroidal injection: B6129SF1 mice injected with original TBP3743 cells (original/129), B6129SF1 mice injected with adapted cells (adapted/129), and C57BL/6 mice injected with adapted cells (adapted/B6).ResultsThe adapted TBP3743 cells de-differentiated but exhibited cell morphology, viability, and migration/invasion potential comparable with those of original cells in vitro. The adapted/129 contained a higher Ki-67+ cell fraction than the original/129. RNA sequencing data of orthotopic tumors revealed enhanced oncogenic properties in the adapted/129 compared with those in the original/129. In contrast, the orthotopic tumors grown in the adapted/B6 were smaller, with a lower Ki-67+ cell fraction than those in the adapted/129. However, the oncogenic properties of the tumors within the adapted/B6 and adapted/129 were similar. Immune-related pathways were enriched in the adapted/B6 compared with those in the adapted/129. Flow cytometric analysis of the orthotopic tumors revealed higher cytotoxic CD8+ T cell and monocytic-myeloid-derived suppressor cell fractions in the adapted/B6 compared with the adapted/129. The estimated CD8+ and CD4+ cell fractions in the adapted/B6 were similar to those in human ATCs but negligible in the original/B6.ConclusionA novel orthotopic tumor model of ATC was established in C57BL/6 mice. Compared with the original B6129SF1 murine model, the novel model exhibited more aggressive tumor cell behaviours and strong immune responses. We expect that this novel model contributes to the understanding tumor microenvironment and provides the platform for drug development.
The Spatial Clustering of ROSAT All-Sky Survey Active Galactic Nuclei. V. The Evolution of Broad-line AGN Clustering Properties in the Last 6 Gyr
Authors: Krumpe Mirko , Miyaji Takamitsu , Georgakakis Antonis , Schulze Andreas , Coil Alison L. , Dwelly Tom , Coffey Damien , Comparat Johan , Aceves Héctor , Salvato Mara , Merloni Andrea , Maraston Claudia , Nandra Kirpal , Brownstein Joel R. , Schneider Donald P. ,   SDSS-IV Team and SPIDERS Team
Published: July 2023

Abstract
This is the fifth paper in a series of investigations of the clustering properties of luminous, broad-emission-line active galactic nuclei (AGNs) identified in the ROSAT All-Sky Survey (RASS) and Sloan Digital Sky Survey (SDSS). In this work we measure the cross-correlation function (CCF) between RASS/SDSS Data Release 14 AGNs with the SDSS CMASS galaxy sample at 0.44 < z < 0.64. We apply halo occupation distribution (HOD) modeling to the CCF along with the autocorrelation function of the CMASS galaxies. We find that X-ray-selected and optically selected AGNs at 0.44 < z < 0.64 reside in statistically identical halos with a typical dark matter halo (DMH) mass of

M

DMH

typ
,
AGN

∼

10

12.7

h

−
1

M

⊙

. The acceptable HOD parameter space for these two broad-line AGN samples have only statistically marginal differences caused by small deviations of the CCFs in the one-halo-dominated regime on small scales. In contrast to optically selected AGNs, the X-ray AGN sample may contain a larger population of satellites at M
DMH ∼ 1013
h
−1
M
⊙. We compare our measurements in this work with our earlier studies at lower independent redshift ranges, spanning a lookback time of 6 Gyr. The comparison over this wider redshift range of 0.07 < z < 0.64 reveals (i) no significant difference between the typical DMH masses of X-ray-selected and optically selected AGNs, (ii) weak positive clustering dependencies of

M

DMH

typ
,
AGN

with L
X and M
BH, (iii) no significant dependence of

M

DMH

typ
,
AGN

on Eddington ratio, and (iv) the same DMH masses host more-massive accreting black holes at high redshift than at low redshifts.
Properties of Binary Systems in a One-dimensional Approximation
Authors: Pourmand Ali , Ivanova Natalia 
Published: July 2023

Abstract
Evolutionary calculations for stars in close binary systems are in high demand to obtain better constraints on gravitational-wave source progenitors, understand transient events from stellar interactions, and more. Modern one-dimensional (1D) stellar codes make use of the Roche lobe radius R
L concept in order to treat stars in binary systems. If the stellar companion is approaching its R
L, mass transfer treatment is initiated. However, the effective acceleration also affects the evolution of a star in a close binary system. This is different from the gravity inside a single star, whether that single star is rotating or not. Here, we present numerically obtained tables of properties of stars in a binary system as a function of the effective potential: volume-equivalent radii of the equipotential surfaces, effective accelerations and the inverse effective accelerations averaged over the same equipotential surfaces, and the properties of the L
1-plane cross sections. The tables are obtained for binaries where the ratios of the primary star mass to the companion star mass are from 10−6 to 105 and include equipotential surfaces up to the star’s outer Lagrangian point. We describe the numerical methods used to obtain these quantities and report how we verified the numerical results. We also describe and verify the method to obtain the effective acceleration for nonpoint mass distributions. We supply a sample code showing how to use our tables to get the average effective accelerations in 1D stellar codes.
Exploring the Impact of Galactic Interactions and Mergers on the Central Star Formation of APEX/EDGE–CALIFA Galaxies
Authors: Garay-Solis Yeny , Barrera-Ballesteros Jorge K. , Colombo Dario , Sánchez Sebastián F. , Lugo-Aranda Alejandra Z. , Villanueva Vicente , Wong Tony , Bolatto Alberto D. 
Published: July 2023

Abstract
Galactic interactions and subsequent mergers are a paramount channel for galaxy evolution. In this work, we use the data from 236 star-forming CALIFA galaxies with integrated molecular gas observations in their central region (approximately within an effective radius)—from the APEX millimeter telescope and the CARMA millimeter telescope array. This sample includes isolated (126 galaxies) and interacting galaxies in different merging stages (110 galaxies; from pairs, merging, and postmerger galaxies). We show that the impact of interactions and mergers in the center of galaxies is revealed as an increase in the fraction of molecular gas (compared to isolated galaxies). Furthermore, our results suggest that the change in star formation efficiency is the main driver for both an enhancement and/or suppression of the central star formation—except in merging galaxies where the enhanced star formation appears to be driven by an increase of molecular gas. We suggest that gravitational torques due to the interaction and subsequent merger transport cold molecular gas inwards, increasing the gas fraction without necessarily increasing star formation.
A NICER View on the 2020 Magnetar-like Outburst of PSR J1846−0258
Authors: Hu Chin-Ping , Kuiper Lucien , Harding Alice K. , Younes George , Blumer Harsha , Ho Wynn C. G. , Enoto Teruaki , Espinoza Cristóbal M. , Gendreau Keith 
Published: July 2023

Abstract
We report on our monitoring of the strong-field magnetar-like pulsar PSR J1846−0258 with the Neutron Star Interior Composition Explorer (NICER) and the timing and spectral evolution during its outburst in 2020 August. Phase-coherent timing solutions were maintained from 2017 March through 2021 November, including a coherent solution throughout the outburst. We detected a large spin-up glitch of magnitude Δν/ν = 3 × 10−6 at the start of the outburst and observed an increase in pulsed flux that reached a factor of more than 10 times the quiescent level, a behavior similar to that of the 2006 outburst. Our monitoring observations in 2020 June and July indicate that the flux was rising prior to the Swift announcement of the outburst on 2020 August 1. We also observed several sharp rises in the pulsed flux following the outburst and the flux reached quiescent level by 2020 November. The pulse profile was observed to change shape during the outburst, returning to the preoutburst shape by 2021. Spectral analysis of the pulsed emission of NICER data shows that the flux increases result entirely from a new blackbody component that gradually fades away while the power law remains nearly constant at its quiescent level throughout the outburst. Joint spectral analysis of NICER and simultaneous NuSTAR data confirms this picture. We discuss the interpretation of the magnetar-like outburst and origin of the transient thermal component in the context of both a pulsar-like and a magnetar-like model.