bluuebunny/crossref_metadata_2025_split huggingface dataset:
The art of arts-based interventions in transdisciplinary sustainability research
Authors: Horvath Sophia-Marie , Payerhofer Ulrike , Wals Arjen , Gratzer Georg 
Published: January 2025

AbstractTransdisciplinary, co-creative research deals with complex real-world problems, with complexity being a common denominator of sustainability issues. It is often understood as an interplay of two dimensions, collaboration and creativity, that facilitates the integration of different forms of knowledge and the creation of transformative outcomes. In the end, it aims to find more holistic and systemic solutions to complex real-world problems. Increasingly, Arts-Based Interventions (ABIs) are proposed to support sustainability-oriented transdisciplinary research. However, little research has been done so far to gauge the extent to which adding arts to the mix actually benefits the transdisciplinary research process and outcomes. In the research project reported on in this article, we took a first step into the realm of the arts by including ABIs into transdisciplinary brainstorming sessions. We investigated their influence on the research process and outcomes as perceived by the participants. We found ABIs to positively influence both dimensions of co-creativity—(1) collaboration, through enhancing the sense of togetherness in the group, and (2) creativity, directly and indirectly through a perceived emotionalization. ABIs were perceived to induce a change of perspective and a broadening of horizons that can facilitate the creation of transformative solutions. Moreover, their reported emotionalizing impact points toward an integration of tacit—in particular emotional—knowledge. This can lead to a more holistic view of the investigated problem. Altogether, the reported impacts of ABIs on transdisciplinary research can promote the creation of transformative and holistic solutions to sustainability issues in transdisciplinary sustainability research.
Effect of physical exercise on white matter microstructure in chemotherapy-treated breast cancer patients: a randomized controlled trial (PAM study)
Authors: Koevoets Emmie W. , Schagen Sanne B. , May Anne M. , Geerlings Mirjam I. , Witlox Lenja , van der Wall Elsken , Stuiver Martijn M. , Sonke Gabe S. , Velthuis Miranda J. , Jobsen Jan J. , van der Palen Job , de Ruiter Michiel B. , Monninkhof Evelyn M. 
Published: January 2025

Abstract
Physical exercise is a promising intervention to improve brain white matter integrity. In the PAM study, exercise intervention effects on white matter integrity were investigated in breast cancer patients. Chemotherapy-treated breast cancer patients with cognitive problems were randomized 2–4 years post-diagnosis to an exercise (n = 91) or control group (n = 90). The 6-month exercise intervention consisted of four hours/week of aerobic and resistance training. White matter integrity was measured at baseline and 6-month follow-up with fractional anisotropy (FA) and mean diffusivity (MD), which were derived from magnetic resonance diffusion tensor imaging (DTI). Both DTI metrics were analyzed whole brain and voxel-wise with a modified tract based spatial statistics (TBSS) procedure. Other measurements included cognition and physical fitness. Exercise effects were analyzed with multiple regression analyses. An explorative analysis was conducted in highly fatigued patients. DTI scans were available for 69 patients of the intervention (age = 52.3 ± 8.9yrs.) and 72 patients of the control group (age = 53.2 ± 8.6yrs.). Whole brain and voxel-wise analyses revealed no significant intervention effects on FA and MD. In highly fatigued patients (exercise: n = 32; control: n = 24), significant clusters of decreased FA post-intervention were observed in the left inferior and superior longitudinal fasciculus. Mean FA in these clusters was not predictive of cognition. A 6-month exercise intervention did not affect white matter integrity in chemotherapy-treated breast cancer patients. However, in highly fatigued breast cancer patients a significant FA decrease was observed post-intervention. The direction of these results is unexpected, and more research is needed to further understand these results.
Structure-H Type Hydrates Containing Cyclooctane-Based Epoxy (Oxirane) Compounds
Authors: Seol Jiwoong 
Published: January 2025

Abstract
Recently, various epoxy (oxirane) compounds have been identified as novel methane hydrate formers, and their hydrates’ structural and thermodynamic properties have been studied. However, most epoxy compounds reported, thus far, are relatively small molecules that form structure-II (sII) hydrates. This study demonstrates that two epoxy compounds, 1,2-epoxycyclooctane and 1,2,5,6-diepoxycyclooctane, which have cyclooctane backbones with one and two epoxy groups, respectively, can form structure-H (sH) hydrates with CH4 help gas and serve as thermodynamic promoters of CH4 hydrates. Crystallographic, spectroscopic, and phase equilibrium analyses indicate that the epoxy group of LGM has minimal effect on the composition of CH4 hydrates (i.e., CH4 storage) but significantly influences equilibrium conditions. The moderate hydrophilicity induced by the epoxy group significantly enhances the thermodynamic stability of the CH4 hydrates. These findings suggest that epoxy compounds have potential as thermodynamic promoters in various hydrate-based technologies.
Old and New Biomarkers in Idiopathic Recurrent Acute Pericarditis (IRAP): Prognosis and Outcomes
Authors: Mascolo Ruggiero , Bizzi Emanuele , Martelli Martina , Facoetti Chiara , Colazzo Giulia , Barone Fabio , Brucato Antonio 
Published: January 2025

Abstract
Purpose of Review
To outline the latest discoveries regarding the utility and reliability of serum biomarkers in idiopathic recurrent acute pericarditis (IRAP), considering recent findings on its pathogenesis. The study highlights the predictive role of these biomarkers in potential short- (cardiac tamponade, recurrences) and long-term complications (constrictive pericarditis, death).

Recent Findings
The pathogenesis of pericarditis has been better defined in recent years, focusing on the autoinflammatory pathway. New studies have demonstrated the pivotal role of the classical inflammatory biomarkers in distinguishing pericarditis phenotypes (high-grade vs. low-grade inflammation) and in defining outcomes of this condition.

Summary
Pericarditis involves intense inflammatory activity, which causes elevation of different markers, such as C-reactive protein, erythrocyte sedimentation rate, neutrophils and platelets, serum amyloid A and D-Dimer. Conversely, lymphocytes are often reduced, as well as hemoglobin during the acute phase. Cardiac troponins T and I are elevated in up to 30% of cases. A Biomarker for CRP-negative cases is needed. Other markers have been proposed for diagnosis and prognosis in IRAP, such as anti-heart antibodies and anti-intercalated disk antibodies, but we need further studies to validate them.
Influence of pH and Sulfur Dioxide in Unaged Wine Distillates on the Physicochemical and Sensory Profile of the Brandies de Jerez
Authors: Butrón-Benítez Daniel , Valcárcel-Muñoz Manuel J. , García-Moreno M. Valme , Rodríguez-Dodero M. Carmen , Guillén-Sánchez Dominico A. 
Published: January 2025

AbstractBrandies are spirits produced from wine spirits and wine distillates aged in less than 1000 L oak casks for at least 6 months. The composition of each brandy is determined by its raw material and its aging. During aging, two different phenomena occur: the extraction of compounds from the cask wood and reactions between the different compounds. Characteristics of the casks have a significant impact during this process. Those casks that have previously contained some type of Sherry wine give rise to the so-called Sherry Cask®, which not only contributes to the compounds from the wood but also to those that were originally found in the Sherry wine previously aged in them. The quality of brandy is also determined by the physicochemical composition and characteristics of the distillate, which depends both on the quality of the distilled wine and on the distillation process itself. This work studied the effect of sulfur dioxide and the role that the pH of the distillate plays on the physicochemical and sensory composition of three brandies aged 24 months in a static system of Sherry Casks®. The analyses were carried out following the OIV methods. Results have revealed that high levels of sulfur dioxide and the distillate pH significantly condition the extraction of phenolic compounds and organic acids from the wood, as well as reactions such as hydrolysis or esterification that take place between the compounds in the spirits. These factors have led to a differentiated sensory evaluation of the final brandies.
Correlation between in vivo imaging and post‑mortem autopsy findings for the medico-legal evaluation of a right hepatic artery pseudoaneurysm as a fatal complication of laparoscopic cholecystectomy
Authors: Pelletti Guido , Sech Maria , Montanari Nicola , Quaia Emilio , Garcea Domenico , Pelotti Susi 
Published: January 2025

AbstractA 36-year-old woman diagnosed with complicated cholecystolithiasis underwent elective laparoscopic cholecystectomy (LC), then converted to open cholecystectomy because of a massive intraoperative bleeding. Hemostasis was performed with clipping and suturing the source of bleeding. In post-operative period, the patient suffered from persistent anemia associated with hemoperitoneum diagnosed through abdominal CT scanning, in absence of any sign of active bleeding. She died 16 days after the surgical procedure. Autopsy revealed the presence of 2 clips adjacent to the suture used for ligating the cystic artery and the presence of 3 surgical metal clips on the right hepatic artery, that should not be present in a routine cholecystectomy. The review of CT scans performed during the hospital stay revealed contrast extravasation from the right hepatic artery, near the 3 clips, allowing the post-mortem diagnosis of pseudoaneurysm (PA). The diagnosis of PA of right hepatic artery is typically made in living patients, through imaging, and autoptic identification is rarely obtained. The innovation of this report is to present an iconographic correlation between in vivo imaging and autopsy data, allowing for the tracing of the PA’s origin to the wall weakening caused by the placement of 3 clips on the right hepatic artery, and having significant medico-legal implications.
Burden, trends, and predictions of liver cancer in China, Japan, and South Korea: analysis based on the Global Burden of Disease Study 2021
Authors: Yang Si , Deng Yujiao , Zheng Yi , Zhang Jing , He Dongdong , Dai Zhijun , Guo Changcun 
Published: January 2025

Abstract
Background
Liver cancer (LC) is a major concern in the Asia-Pacific region, particularly in China, Korea, and Japan. In this study, we aimed to investigate the burden, trends, and predictions related to LC in these countries.

Methods
Using data from the Global Burden of Disease Study 2021, the epidemiological characteristics [incidence, deaths, and disability-adjusted life-years (DALYs)] for LC were analysed and stratified by specific etiologies in China, Japan, and South Korea. We examined temporal trends in LC burden over the last 32 years and projected changes over the following 25 years. The risk factors associated with LC deaths and DALYs were also investigated.

Results
In 2021, the highest LC-related incidence, mortality, and DALYs were recorded in China (196,637 incidents, 172,068 mortalities, and 4,890,023 DALYs), and the lowest in South Korea (18,642 incidents, 13,674 deaths, and 326,336 DALYs). South Korea recorded the highest age-standardized rates (ASRs) of incidence, mortality, and DALYs for LC (19.94 per 100,000, 14.53 per 100,000, and 354.57 per 100,000), and Japan the lowest (9.89, 7.29, and 145.74, respectively). From 1990 to 2021, LC incidents and deaths in the three countries increased, and the trends in ASRs decreased. LC incidents and deaths caused by five etiologies also increased in the past 32 years, and non-alcoholic steatohepatitis (NASH) was the largest increasing etiologies in China. Infections with hepatitis B virus remained the leading cause of LC in China and South Korea, while hepatitis C virus was the prevailing cause in Japan. High body mass index (BMI) was the most sharply increasing risk factor in China. Alcohol and drug use were the main risk factors for LC in South Korea and Japan, respectively. The LC burden in the three countries was projected to rise steadily between 2022 and 2046.

Conclusions
LC remains a significant disease burden in China, Japan, and South Korea now and over the next 25 years. Regarding etiologies and risk factors, NASH and high BMI in China, alcohol use in South Korea, and drug use in Japan should receive significant attention.
Primary Liver Rhabdomyosarcoma with Burnt-out Paravertebral Disease
Authors: Niharika Vadisetti Satya , Patkar Shraddha , Pai Trupti , Qureshi Sajid 
Published: January 2025

AbstractLess than 20 cases of primary hepatic rhabdomyosarcoma have been reported in literature. The authors present this occurrence in a neonate with paravertebral and peritoneal disease. Histopathology was the solution to authors’ diagnostic dilemma. Multimodality management is the solution for rare cases where specific guidelines are not yet defined. This is a rare case reporting a primary liver rhabdomyosarcoma with peritoneal disease with excellent survival.
Life Stressors, Social Support, and Children’s Subjective Well-Being during the COVID-19 Pandemic: Evidence from a Cross-National Survey of 20 Societies
Authors: Chen Xi , Kühner Stefan 
Published: January 2025

AbstractThe COVID-19 pandemic has profoundly affected the well-being of people across all age groups, with children being particularly vulnerable due to their reliance on stable routines and social interactions for healthy development. Guided by stress-coping theory, this study examines the impact of life stressors and social support on children’s subjective well-being during the COVID-19 pandemic. Using a large-scale, cross-national dataset of 20,047 children aged 7–15 from 20 societies, we assessed how various stressors and social support from friends, family, and teachers influenced indicators of subjective well-being, including life satisfaction, happiness, positive affect, and negative affect. Multilevel regression analyses revealed that virus-related stressors and pandemic-induced disruptions negatively impacted children’s subjective well-being. Conversely, social support from family, friends, and teachers was generally associated with better well-being. However, the role of social support in moderating stress was complex: while support from friends buffered the adverse effects of stressors on life satisfaction and positive affect, family support sometimes amplified the negative impact of stressors, demonstrating a reverse buffering effect. These findings underscore the critical role of life stressors and social support in shaping children’s well-being during crises and highlight the need for targeted interventions to strengthen social connections and support systems.
Value Sensitive Design of Social Robots: Enhancing the Lives of LGBT+ Older Adults
Authors: Poulsen Adam , Burmeister Oliver K. , Greig Jenni , Ulhaq Anwaar , Tien David 
Published: January 2025

Abstract
The integration of care and social robots in aged care offers a promising solution to the increasing global challenges posed by an ageing population and caregiver shortages. While these robots have demonstrated promising outcomes in enhancing emotional wellbeing and social interactions among older adults, there are legitimate concerns regarding the ethical implications, particularly regarding dignity, privacy, and autonomy. Furthermore, marginalised groups, such as LGBT+ older adults, which face existing disparities in old age are at risk of exclusion in the implementation of social robots in aged care. To better account for the diverse set of stakeholder values within the social robot ecosystem, this study applies a value sensitive design approach to a case study: social robot interventions to address the problem of loneliness in the older LGBT+ community. It aims to understand the values of LGBT+ older adults relating to the design of social robots intended to alleviate loneliness and explore emerging value sensitive robot design recommendations. To that end, 33 semi-structured interviews were conducted with LGBT+ older adults, healthcare professionals and LGBT+ ageing service providers, and robot experts. Using reflexive thematic analysis, this study identifies three themes—care values, social values, and community values—and 16 values relevant to the design of social robots for LGBT+ older adults. Further, this study contributes practical, value sensitive design recommendations for social robots in this context, as they emerge from the findings.
Proximale Hautatrophie und positive NOR-90-Antikörper: atypische systemische Sklerodermie oder Lipodystrophie?
Authors: Rademacher Jan-Gerd 
Published: January 2025

Zusammenfassung
Die systemische Sklerodermie ist eine potenziell lebensbedrohliche Erkrankung mit Fibrosierung unterschiedlicher Organsysteme. Eine namensgebende Sclerosis cutis beginnt in der Regel distal und kann nach proximal fortschreiten. Es wird der Fall einer 55-jährigen Patientin demonstriert, die sich zur rheumatologischen Abklärung mit isoliert proximaler und symmetrischer Lipoatrophie sowie Nachweis von Antikörpern gegen Nucleolus Organizer Region 90 (NOR-90) vorstellte. Die Differenzialdiagnose der Lipodystrophie (LD) umfasst neben der Beurteilung der Lokalisation und metabolischer Erkrankungen eine genaue Medikamentenanamnese. Im vorliegenden Fall führte die subkutane Injektion von Piritramid über mindestens 18 Monate zu einer ausgeprägten lokalen LD und imitierte aufgrund der symmetrischen Verteilung eine systemische Erkrankung.
The Contribution of Reward Systems in the Work Context: A Systematic Review of the Literature and Directions for Future Research
Authors: Figueiredo Elisabeth , Margaça Clara , García José Carlos Sánchez , Ribeiro Célia 
Published: January 2025

AbstractCurrently, companies face several challenges and are increasingly concerned about human capital, particularly after the pandemic period. Reward systems emerge as a powerful resource to influence workers’ behavior. This study systematically reviews 61 articles on reward systems in an organizational context, and the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) protocol and three databases were used. By limiting the year range, it was possible to confirm that there was an increase in scientific production in the post-pandemic. This research provides a significant contribution to academia and to organizations by offering deeper insights into how reward systems shape the management of intellectual capital, facilitate knowledge sharing within organizations, and foster innovation. The results also offer organizations differentiated strategies, helping them, in the current business environment, to manage their best talents more efficiently, increasing competitiveness.
Macrophages co-loaded with drug-associated and superparamagnetic nanoparticles for triggered drug release by alternating magnetic fields
Authors: Desai Omkar , Kumar Sandhya , Köster Mario , Ullah Sami , Sarker Sushobhan , Hagemann Valentin , Habib Mosaieb , Klaassen Nicole , Notter Silke , Feldmann Claus , Ehlert Nina , Hauser Hansjörg , Wirth Dagmar 
Published: January 2025

Abstract
Two features of macrophages make them attractive for targeted transport of drugs: they efficiently take up a broad spectrum of nanoparticles (NPs) and, by sensing cytokine gradients, they are attracted to the sites of infection and inflammation. To expand the potential of macrophages as drug carriers, we investigated whether macrophages could be simultaneously coloaded with different types of nanoparticles, thus equipping individual cells with different functionalities. We used superparamagnetic iron oxide NPs (SPIONs), which produce apoptosis-inducing hyperthermia when exposed to an alternating magnetic field (AMF), and co-loaded them on macrophages together with drug-containing NPs (inorganic–organic nanoparticles (IOH-NPs) or mesoporous silica NPs (MSNs)). We show that individual macrophages can take up both SPIONs and drug-loaded NPs efficiently, thereby generating drug-loaded cells susceptible to AMF-induced cell death. Macrophages co-loaded with SPIONs and drug-containing IOH-NPs spontaneously released the drugs at similar rates irrespective of the application of an AMF. Notably, while the spontaneous drug release from macrophages co-loaded with SPIONs and drug-associated MSNs was low, AMF exposure accelerated the drug release. Thus, AMF exposure of SPION/drug-MSN coloaded macrophages provides a simple strategy for trigger-controlled drug release since it does not require any chemical modification of NPs or drugs. Thus, we assume that the coloading of different types of NPs will expand the potential of macrophages for drug delivery.

Graphical Abstract
Breaking Ground: From CPAP Treatment to the First Medicine for OSA Patients with Obesity
Authors: Lisik Daniil , Zou Ding 
Published: January 2025

Abstract
Purpose of Review
Pharmacologic alternatives in management of obstructive sleep apnea (OSA) have been pursued for decades. Considering rapid development and promising findings in recent years, we provide an overview of novel agents and treatment targets, ongoing trials, as well as future perspectives.

Recent Findings
Several drugs demonstrate efficacy, though none is sufficient to cure the disease as a monotherapy. Instead, the main potential lies in applying drug therapy in specific subgroups or as an addition to established treatments (e.g., positive airway pressure, oral appliance therapy). Glucagon-like peptide-1 (GLP-1)/glucose-dependent insulinotropic polypeptide (GIP) receptor agonists may be particularly beneficial in obese OSA patients. As a major breakthrough, terzipatide, a GIP analog and GLP-1 receptor agonist, has become the first FDA-approved and EMA-sanctioned pharmacologic treatment option of OSA in obese individuals. Beyond this, alerting drugs could help manage residual daytime sleepiness and improve daytime functioning. However, long-term studies on safety, adherence, and effectiveness are scarce and highlight certain limitations and challenges.

Summary
Incorporating pharmaceuticals along conventional OSA management may provide synergy benefit in certain patients, but side-effects and risk reduction of related adverse outcomes over time is yet to be assessed. Furthermore, guidelines/frameworks for mapping out applicable treatment targets are needed.