bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of supportive and minimalist footwear on standing balance and walking stability in older women
Authors: Azhar Ameer Nor , Munteanu Shannon E. , Menz Hylton B. 
Published: June 2023

AbstractBackgroundFootwear has been shown to influence balance and is an important consideration in relation to the prevention of falls. However, it remains unclear as to what type of footwear is most beneficial for balance in older people: sturdy, supportive footwear, or minimalist footwear to maximise plantar sensory input. The objectives of this study were therefore to compare standing balance and walking stability in older women wearing these two footwear styles, and to investigate participants' perceptions in relation to comfort, ease of use and fit.MethodsOlder women (n = 20) aged 66 to 82 years (mean 73.4, SD 3.9) performed a series of laboratory tests of standing balance (eyes open and closed on floor and foam rubber mat, near tandem standing) and walking stability (treadmill, level and irregular surface) using a wearable sensor motion analysis system. Participants were tested wearing supportive footwear (incorporating design features to improve balance) and minimalist footwear. Perceptions of the footwear were documented using structured questionnaires.ResultsThere were no statistically significant differences in balance performance between the supportive and minimalist footwear. Participants perceived the supportive footwear to be significantly more attractive to self and others, easier to put on and off but heavier compared to the minimalist footwear. Overall comfort was similar between the footwear conditions, although the supportive footwear was reported to be significantly more comfortable in the heel, arch height, heel cup, heel width and forefoot width regions. Eighteen participants (90%) reported that they felt more stable in the supportive footwear and 17 (85%) reported that they would consider wearing them to reduce their risk of falling.ConclusionBalance performance and walking stability were similar in supportive footwear designed to reduce the risk of falling and minimalist footwear, although participants preferred the supportive footwear in relation to aesthetics, ease of use, comfort and perceived stability. Prospective studies are now required to ascertain the longer‐term advantages and disadvantages of these footwear styles on comfort and stability in older people.Trial registrationAustralian New Zealand Clinical Trials Registry. ACTRN12622001257752p, 20/9/2022 (prospectively registered).
The Bovine Pangenome Consortium: democratizing production and accessibility of genome assemblies for global cattle breeds and other bovine species
Authors: Smith Timothy P. L. , Bickhart Derek M. , Boichard Didier , Chamberlain Amanda J. , Djikeng Appolinaire , Jiang Yu , Low Wai Y. , Pausch Hubert , Demyda-Peyrás Sebastian , Prendergast James , Schnabel Robert D. , Rosen Benjamin D. ,   Bovine Pangenome Consortium
Published: June 2023

AbstractThe Bovine Pangenome Consortium (BPC) is an international collaboration dedicated to the assembly of cattle genomes to develop a more complete representation of cattle genomic diversity. The goal of the BPC is to provide genome assemblies and a community-agreed pangenome representation to replace breed-specific reference assemblies for cattle genomics. The BPC invites partners sharing our vision to participate in the production of these assemblies and the development of a common, community-approved, pangenome reference as a public resource for the research community (https://bovinepangenome.github.io/). This community-driven resource will provide the context for comparison between studies and the future foundation for cattle genomic selection.
PSMD3-ILF3 signaling cascade drives lung cancer cell proliferation and migration
Authors: Zhang Jin , Ma Qianli , Yu Qiduo , Xiao Fei , Zhang Zhenrong , Feng Hongxiang , Liang Chaoyang 
Published: June 2023

Abstract
Background
Proteasome 26S subunit, non-ATPase 3 (PSMD3) has been reported to participate in various human cancers. Nevertheless, the function of PSMD3 in lung cancer (LC) remains unclear.

Methods
RT-qPCR and western blot were used to detect the expression of PSMD3 in LC tissues form TCGA database and clinical samples, and LC cell lines. To study the effect of PSMD3 on LC cell proliferation, migration, invasion, and apoptosis, siRNAs targeting PSMD3 were synthesized and overexpressed plasmids were constructed. CCK-8 assay, Transwell assay, and etc. were used to evaluate the results. Tumor xenograft model was used to evaluate the function of PSMD3 on tumor growth. CO-IP and MS were used to scan the proteins that bind with PSMD3. The interaction between PSMD3 and ILF3 in lung cancer cells were studied using IF staining, CHX protein stability, and ubiquitination assay. Additionally, the effect of ILF3 on cell progression and LC tumor growth was demonstrated by conducting a recovery assay using siILF3 and an ILF3 inhibitor YM155.

Results
We observed that PSMD3 was significantly overexpressed in LC tissues and cells, which indicated a poor prognosis. Meanwhile, we found that PSMD3 promoted cell proliferation, migration, and invasion of LC cells. We also determined that PSMD3 stabilized the protein expression of ILF3 and the deubiquitination of ILF3 in lung cancer cells. Furthermore, animal experiments showed that the ILF3 inhibitor YM155 could suppress tumor growth with the presence of PSMD3.

Conclusions
PSMD3 collectively regulated the stability of ILF3 protein and facilitated the ubiquitination of endogenous ILF3 in LC, which ultimately promoted the progression of LC cells. The PSMD3/ ILF3 axis could potentially be used as a novel strategy for both diagnosis and treatment of LC.
Effect of an intraoperative periradicular application of platelet-rich fibrin (PRF) on residual post-surgical neuropathic pain after disc herniation surgery: study protocol for NeuroPRF, a randomized controlled trial
Authors: Todeschi Julien , Dannhoff Guillaume , Coca Andres Hugo , Timbolschi Daniel Ionut , Proust François , Lefebvre François , Lelievre Vincent , Poisbeau Pierrick , Vallat Laurent , Salvat Eric , Bohren Yohann 
Published: June 2023

Abstract
Background
The prevalence of post-surgical lumbar neuropathic radiculopathy is approximately 30%. Poor response to the recommended treatments for neuropathic pain, namely antidepressants and/or gabapentinoids, requires the development of new techniques to prevent chronic pain. One such well-tolerated technique is the administration of autologous plasma enriched in platelets and fibrin (PRF). This approach is largely used in regenerative medicine owing to the anti-inflammatory and analgesic properties of PRF. It could also be an interesting adjuvant to surgery, as it reduces neurogenic inflammation and promotes nerve recovery, thereby reducing the incidence of residual postoperative chronic pain. The aim of the present study is to evaluate the benefit of periradicular intraoperative application of PRF on the residual postsurgical neuropathic pain after disc herniation surgery.

Methods
A randomized, prospective, interventional, controlled, single-blind study with evaluation by a blind outcome assessor will be performed in Strasbourg University Hospital. We will compare a control group undergoing conventional surgery to an experimental group undergoing surgery and periradicular administration of PRF (30 patients in each arm). The primary outcome is the intensity of postoperative neuropathic radicular pain, measured by a visual analog scale (VAS) at 6 months post-surgery. The secondary outcomes are the characteristics of neuropathic pain (NPSI), the quality of life (SF-12 and PGIC), the presence of anxiety/depression symptoms (HAD), and the consumption of analgesics. We will also carry out transcriptomic analysis of a panel of pro- and anti-inflammatory cytokines in blood samples, before surgery and at 6 months follow-up. These gene expression results will be correlated with clinical data, in particular, with the apparition of postoperative neuropathic pain.

Discussion
This study is the first randomized controlled trial to assess the efficacy of PRF in the prevention of neuropathic pain following surgery for herniated disc. This study addresses not only a clinical question but will also provide information on the physiopathological mechanisms of neuropathic pain.

Trial registration
This study is registered at ClinicalTrials.gov: NCT05196503, February 24, 2022.
The value of pre-symptomatic genetic risk assessment for age-related macular degeneration: the Moran AMD Genetic Testing Assessment (MAGENTA) study—a study protocol for a randomized controlled trial
Authors: Addo Emmanuel K. , Hartnett M. Elizabeth , Bernstein Paul S. 
Published: June 2023

Abstract
Background
Age-related macular degeneration (AMD) is an irreversible blinding eye condition with complex genetic and environmental etiologies. Genetic testing for AMD for previously identified multiple-risk single nucleotide polymorphisms can help determine an individual’s future susceptibility. However, such testing has been discouraged until evidence shows that providing such information to symptomatic or pre-symptomatic individuals will alter their disease course. Therefore, we designed this study to investigate whether knowledge of AMD risk could stimulate the adoption of a healthier lifestyle that could lower the incidence of AMD later in life. We hypothesize that pre-symptomatic individuals informed of a high genetic risk of AMD are more likely to make quantifiable, positive lifestyle changes relative to participants informed of lower genetic risk or randomized to deferred disclosure of genetic testing results.

Methods
The Moran AMD Genetic Testing Assessment (MAGENTA) study is a phase 2, single-center, prospective, double-masked, randomized controlled trial conducted at the John A. Moran Eye Center, University of Utah, Salt Lake City, Utah, USA. Participants are randomized by a 3:1 allocation ratio to immediate and deferred disclosure groups and followed for 12 months. Skin, ocular, and serum carotenoid status, as well as nutritional and social surveys, are assessed at study visits. Skin carotenoid assessment is by resonance Raman spectroscopy and reflectance spectroscopy, ocular carotenoids are measured with Heidelberg Spectralis autofluorescence imaging and fluorescence lifetime imaging ophthalmoscopy (FLIO), and serum carotenoids are quantified using high-performance liquid chromatography. The primary outcome evaluates changes in skin carotenoid status in response to genetic risk disclosure. The secondary outcomes examine changes in ocular and serum carotenoid status in response to genetic risk disclosure. Also, we will correlate AMD genetic risk with baseline ocular and systemic carotenoid status and FLIO.

Discussion
MAGENTA will provide much-needed evidence on whether pre-symptomatic testing for AMD risk can lead to quantifiable long-term changes in behavior and lifestyle associated with a lower incidence of AMD later in life. Findings from the MAGENTA trial will facilitate the design of a future larger, longer-term, multicenter phase 3 trial that could feature subgroup analysis, expanded measures of lifestyle modification, and potential active nutritional interventions.

Trial registration
ClinicalTrials.gov NCT05265624. Registered on March 3, 2022.
Rivaroxaban in patients with abdominal aortic aneurysm and high-sensitivity C-reactive protein elevation (BANBOO): study protocol for a randomized, controlled trial
Authors: Li Jingyuan , Ma Sicong , Jia Xiu , Bu Yingzhen , Zhou Tienan , Zhang Lei , Qiu Miaohan , Wang Xiaozeng 
Published: June 2023

Abstract
Background
Abdominal aortic aneurysm (AAA) is a fatal disease due to the tendency to rupture. The drug treatment for small AAA without surgical indications has been controversial. Previous studies showed that high-sensitivity C-reactive protein (hs-CRP) had become a potential biomarker of the disease, and the anti-inflammatory effect of rivaroxaban for AAA had been well established. Thus, we hypothesized that rivaroxaban could control the progression of AAA in patients with hs-CRP elevation.

Methods
The study is a prospective, open-label, randomized, controlled clinical trial. Sixty subjects are recruited from the General Hospital of Northern Theatre Command of China. Subjects are randomly assigned (1:1) to the intervention arm (rivaroxaban) or control arm (aspirin). The primary efficacy outcome is the level of serum hs-CRP at 6 months. The secondary outcomes include imaging examination (the maximal diameter of AAA, the maximal thickness of mural thrombus, and the length of aneurysm), major adverse cardiovascular and cerebrovascular events (MACCE, including AAA transformation, non-fatal myocardial infarction, acute congestive heart failure, stent thrombosis, ischemia-driven target vessel revascularization, vascular amputation, stroke, cardiovascular death, and all-cause death), and other laboratory tests (troponin T, interleukin 6, D-dimer, and coagulation function).

Discussion
The BANBOO trial tested the effect of rivaroxaban on the progression of AAA in patients with elevated Hs-CRP for the first time.

Trial registration
ChiCTR2100051990, ClinicalTrials.gov, registered on 12 October 2021.
Colorectal cancer: a qualitative study of coping strategies used by survivors, with associated social determinants
Authors: González-Herrera Antonio , Pujol-Ribera Enriqueta , Esteva Magdalena , Ruiz-Marcos Lorena , March Sebastià 
Published: June 2023

Abstract
Background
Colorectal cancer survivors have to develop coping strategies during the diagnosis and survivorship period. This study aims to identify coping strategies in patients with colorectal cancer, in particular the differences between coping strategies during the disease and throughout survival. It also aims to investigate the impact of some social determinants on coping strategies and critically reflect on the influence of positive psychology.

Methods
Qualitative study with in-depth interviews of a purposive sample of 21 colorectal cancer survivors in Majorca (Spain), developed between 2017–2019. Data was analysed using interpretive thematic analysis.

Results
We observed different coping strategies during the stages of disease and survival. However, striving toward acceptance and adaptation when facing difficulties and uncertainty, predominate in both stages. Confrontational attitudes are also considered important, as well as encouraging positive rather than negative feelings, which are considered unhelpful and to be avoided.

Conclusions
Although coping during illness and survival can be classified into common categories (problem and emotion-centred strategies), the challenges of these stages are faced differently. Age, gender and the cultural influence of positive psychology strongly influence both stages and strategies.
Energy cooperatives and just transition in Southeastern Europe
Authors: Končalović D. , Nikolić J. , Džokić A. , Momčilović P. , Živković D. 
Published: June 2023

Abstract
Background
The energy markets of Southeastern Europe largely depend on fossil fuels. Energy prices are lower in this region than in the rest of Europe, while the energy transition is relatively delayed. This paper aims at summarizing the obstacles to the civic energy transition in Southeastern Europe and the future prospects for its success.

Results
In Southeastern Europe, there are great concerns about the uncertainty of the energy transition process and its outcomes. There is a lot of apprehensions that the transition could drift away from the citizens and end up in the hands of large-scale solar and wind farms entirely. In other words, citizens may be completely excluded from participating in the energy transition. Renewable energy cooperatives can serve as a crucial vehicle for organizing and engaging citizens in the energy transition. They can also be used as a lever of civic influence. This influence is crucial for ensuring a fair transition. The research methodology on cooperative development includes a literature review and a survey conducted with 240 participants. The participants were local government officials, members of NGOs, businesses, scholars, and citizens. The paper summarizes the answers to the questions which the authors considered essential for deepening our understanding of citizens’ attitudes on a (just) energy transition. The results show that the public awareness about the energy transition has increased. In addition, participants have demonstrated a willingness to take action, both as individuals and through cooperative efforts. However, they have also shown a great level of mistrust in the government, mainly due to perceived corruption and lack of transparency. Generally speaking, they have doubts that the energy transition can be completed in a fair and timely manner within their national context.

Conclusions
This paper provides insight into the current state of affairs and the prospects for the energy transition based on the attitudes of the citizens in Southeastern Europe. The paper argues that energy cooperatives should be employed as a training ground for the citizens, since, through joint actions, their trust in each other can be regained, rehearsed, and restored.
Characterization of materials in the late 15th-century animal encyclopedia at an Ottoman Library and detection of deterioration products by HPLC–DAD
Authors: Torgan Güzel Emine , Karadag Recep , Baydar Nil 
Published: June 2023

Abstract
There are many manuscripts in institutions that preserve and exhibit cultural heritage such as museums, galleries, and libraries. These manuscripts are of great value because of their witnessing to the past and the historical and cultural significance they have accumulated. In addition to the organic nature and the natural aging of the paper, which is generally used as the primary carrier material in these objects, other materials used in the manuscripts are an obstacle to their preservation and reaching future generations. In this study, the 62-volume animal encyclopedia, which is known to be written in the name of animals, plants, and Islamic science at the end of the fifteenth century (1487–1501) and added to an Ottoman Library, was examined analytically. A total of 40 samples consisting of paper, ink, dye, and leather samples were analyzed using high performance liquid chromatography with a diode array detector (HPLC–DAD). After all, information on material characterization and deterioration product(s) was obtained. As a result of the analysis, vanillic acid, and its derivatives due to the natural aging of the paper and chrysophanic acid and its derivatives caused by fungi, which are the result of unfavorable environmental factors, were determined. It was concluded that the ink used in the manuscripts was iron-gall ink. In addition, it was determined that madder, weld, buckthorn, redwood, rhubarb, or dock plants were used as dyestuffs in paper and leather samples. Also, it was deduced that the leather samples were tanned with the vegetable tanning method using tannins. Since tannic acids were determined in the dyestuff analysis of three paper samples with ink, elemental analysis was performed on black ink by scanning an electron microscope with energy-dispersive X-ray spectroscopy (SEM–EDX). As a result of this analysis, the element of iron has been detected and it has been confirmed that the black ink is iron-gall ink. It is inevitable that this study will guide conservation experts in restoration and conservation studies.
Source mechanisms and triggering process for the April 12th and 13th, 2014 earthquake doublet in the Solomon Islands
Authors: Qwana Calvin Luiramo , Miyazawa Masatoshi , Mori James 
Published: June 2023

AbstractMw 7.6 and Mw 7.4 earthquakes occurred 16 h apart on April 12 and April 13, 2014, at depths of 15 km and 35 km, respectively, southwest of Makira Island (San Cristobal) in the Solomon Islands. We study the source mechanisms to investigate the interrelation between the two events, and to investigate why the Solomon Islands have a historically high rate of doublet earthquakes. Teleseismic P waveform data for both events were used to obtain the slip distributions for the two earthquakes by a finite fault slip inversion method. The Mw 7.6 event is an east–west left-lateral strike slip, where the maximum slip is observed 8–24 km east of the hypocenter. The Mw 7.4 earthquake is a thrust event with north and south-dipping nodal planes. The fault plane is not clear from the aftershock distribution, but the north-dipping plane considered to be the likely fault plane because of the simpler slip distribution compared to the south-dipping plane. The static Coulomb failure stress changes caused by the first earthquake were calculated in the region of the second earthquake. The results show that there was a + 48.59 kPa change at the hypocenter for the assumed north-dipping plane and + 18.24 kPa for the assumed south-dipping plane of the Mw 7.4 event. The temporal pattern of aftershocks shows a possible rate increase of stress prior to the occurrence of the Mw 7.4 events, which may also contribute to the triggering of the second event by static Coulomb Stress changes. We propose a model that supports the geological complexity of the region that may encourage such doublet events.
Graphical Abstract
Liver abscess caused by Clostridium perfringens after left hepatic trisectionectomy for perihilar cholangiocarcinoma: a case report
Authors: Tohmatsu Yuuko , Yamada Mihoko , Otsuka Shimpei , Ohgi Katsuhisa , Ashida Ryo , Kurai Hanako , Yasui Haruna , Sugino Takashi , Uesaka Katsuhiko , Sugiura Teiichi 
Published: June 2023

Abstract
Background
Clostridium perfringens sepsis has been reported to have a rapid onset and severe clinical outcome. We herein report a case of C. perfringens sepsis associated with massive intravascular hemolysis after left hepatic trisectionectomy for perihilar cholangiocarcinoma.

Case presentation
A 72-year-old woman underwent left hepatic trisectionectomy for perihilar cholangiocarcinoma. Her postoperative course was uneventful except for bile leakage. She was discharged on postoperative day (POD) 35. On POD 54, she was readmitted because of abdominal pain with a high fever. Although her vital signs were stable on arrival at the hospital, a laboratory examination showed a severe inflammatory reaction and hemolysis, and she had developed disseminated intravascular coagulation. Abdominal contrast-enhanced computed tomography showed a 70-mm irregular shape and low-density containing air in liver segment 6, which suggested a liver abscess. The abscess was immediately drained of pus containing air. The pus showed multiple Gram-positive bacilli, and two blood cultures showed Gram-positive bacilli and hemolysis. Empirical antibiotic therapy with vancomycin and meropenem was started because C. perfringens was detected from the preoperative bile culture. Four hours after arrival, tachypnea and decreased oxygen saturation were observed. Her general condition deteriorated rapidly with significant hypoglycemia, progressive acidosis, anemia, and thrombocytopenia. Despite rapid drainage and empiric therapy, she died six hours after her arrival. At autopsy, the abscess consisted of coagulation necrosis of liver cells with inflammatory cell infiltration, and clusters of Gram-positive large bacilli were observed in the necrotic debris. C. perfringens was detected in the drainage fluid and blood culture. She was diagnosed with a liver abscess and severe sepsis caused by C. perfringens and treated promptly, but the disease progressed rapidly and led to her death.

Conclusions
Sepsis caused by C. perfringens can progress rapidly and lead to death in a few hours, so prompt treatment is needed. When patients who have undergone highly invasive hepatobiliary-pancreatic surgery show hemolysis and hepatic abscesses with gas, C. perfringens should be considered the most likely bacterium.