bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recent Research Progress into Zinc Ion Battery Solid‐Electrolyte Interfaces
Authors: Li Le , Jia Shaofeng , Cheng Zhiyi , Zhang Changming 
Published: June 2023

AbstractAqueous zinc ion batteries (ZIBs) are prospective next‐generation energy storage device candidates owing to resource abundance, affordability, eco‐friendliness, and safety. The solid‐electrolyte interface (SEI) produced in a ZIB by electrolyte/electrode interactions significantly impacts battery performance. The SEI is known to promote dendrite growth, determine the electrochemical stability window, passivate zinc‐metal‐anodic corrosion, and mutate the electrolyte. Accordingly, the SEI is closely related to the overall property of a ZIB device. This review provides an overview of the impact of SEIs on ZIB performance recently and provides an SEI design strategy based on the formation mechanism, type, and characteristics of the SEI. Finally, future investigational directions for SEIs in ZIBs are expected to lead to a deep understanding of the SEI, enhance ZIB performance, and facilitate their extensive implementation.
Design of new metamaterial with negative permeability for efficient wireless power transfer
Authors: Wang Meng , Wang Mengmeng , Shi Yanyan , Guo Jingjing , Song Guangcheng , Yin Renliang 
Published: June 2023

SummaryTo solve the problem that the efficiency of a wireless power transfer system decreases with increasing transmission distance, metamaterial (MTM) has offered an effective solution. In this paper, a novel compact MTM with negative permeability is designed to improve the transfer efficiency of wireless power transfer at the operating frequency of 13.56 MHz. By placing the MTM slab at different positions between coils, the transmission coefficient of the wireless power transfer system with one MTM slab is calculated. Also, the impact of transmission distance is studied. Based on the two‐port network method, the transfer efficiency of wireless power transfer is respectively calculated for the system with one MTM slab and with two MTM slabs. The results demonstrate that transfer efficiency at the transmission distance of 150, 200, and 250 mm are, respectively, 82.4%, 67.8%, and 47.3% when one MTM slab is introduced. For the system with two MTM slabs, the corresponding transfer efficiency is 84.9%, 77.3%, and 66.1% separately. Compared with the system without MTM, it is found that there is a large improvement in transfer efficiency especially when two MTM slabs are positioned between coils at the transmission distance of 250 mm. The magnetic field distribution of the system with one or two MTM slabs introduced is investigated. The results show that magnetic coupling between coils is strengthened, which is favorable for transfer efficiency enhancement.
BMP6 knockdown enhances cardiac fibrosis in a mouse myocardial infarction model by upregulating AP‐1/CEMIP expression
Authors: Lu Guiping , Ge Zhuowang , Chen Xinyuan , Ma Yue , Yuan Ancai , Xie Yuquan , Pu Jun 
Published: June 2023

AbstractBackgroundThe cardiac repair process following a myocardial infarction is a key factor in patient prognosis. In this repair process, cardiac fibrosis takes a critically important role. Among those featured genes for fibrosis, transforming growth factor beta (TGF‐β) is known to be involved in the fibrosis in various organs. And bone morphogenetic protein (BMP)6 belongs to the TGF‐β superfamily. Although BMPs are known to play exclusive roles in cardiac repair processes, the character of BMP6 in cardiac remodelling remains unclear.PurposeThis study aimed to investigate how BMP6 functioned in cardiac fibrosis following myocardial infarction (MI).ResultsIn this paper, we demonstrated that BMP6 expression was upregulated after myocardial infarction in wild‐type (WT) mice. Furthermore, BMP6−/− mice showed a more significant decline in cardiac function and lower survival curves after MI. An enlarged infarct area, increased fibrosis and more pronounced inflammatory infiltration were observed in BMP6−/− mice compared to WT mice. The expression of collagen I, collagen III and α‐SMA was increased in BMP6−/− mice. In vitro, through gain‐of‐function and loss‐of‐function experiments, it was demonstrated that BMP6 decreases collagen secretion in fibroblasts. Mechanistically, knocking down BMP6 promoted AP‐1 phosphorylation, which in turn promotes CEMIP expression, led to an acceleration in the progression of cardiac fibrosis. Finally, it was found that rhBMP6 would alleviate ventricular remodelling abnormalities after myocardial infarction.ConclusionTherefore, BMP6 may be a novel molecular target for improving myocardial fibrosis and cardiac function after myocardial infarction.
Oblique Bernstein wave propagation in electron‐ion plasma with electron quantization effects
Authors: Hussain A. , Majeed A. , Ayub M. , Murtaza G. , Iqbal Z. 
Published: June 2023

AbstractWe have studied the role of electron quantization effects on the dispersion characteristics of the oblique electron Bernstein wave (EBW) in an electron‐ion plasma using Vlasov‐Poisson model. Our analysis shows that large thermal effects (as compared to quantization effects) give rise to the usual classical results while in the limit of strong magnetic field, the dispersion characteristics changes. The existence of a quantum Bernstein mode has been proposed which appears purely due to the electron quantization effects. The damping of the oblique EBW has also been analyzed in detail and we found that the magnitude of the damping of the wave decreases as we decrease the obliqueness parameter (parallel to perpendicular wavenumber ratio) which agrees with the earlier theoretical and experimental findings. Moreover, the strong quantization effects () also tend to suppress the damping of EBW which contributes to the stabilization of the waves. The present findings are relevant to the laboratory laser‐produced plasmas where strong external magnetic fields exist, and also to the dense astrophysical plasma environments.
Antibody titrations are critical for microflow cytometric analysis of extracellular vesicles
Authors: Pink Desmond , Basu Arghya , Wong Michael , Pham Diana , Valencia Juliana , Triana Vivian , Beatty Perrin H. , Rieger Aja M. , Lewis John D. 
Published: June 2023

AbstractOptimization of flow cytometry assays for extracellular vesicles (EVs) often fail to include appropriate reagent titrations – the most critically antibody titration is either not performed or is incomplete. Using nonoptimal antibody concentration is one of the main sources of error leading to a lack of reproducible data. Antibody titration for the analysis of antigens on the surface of EVs is challenging for a variety of technical reasons. Using platelets as surrogates for cells and platelet‐derived particles as surrogates for EV populations, we demonstrate our process for antibody titration, highlighting some of the key analysis parameters that may confound and surprise new researchers moving into the field of EV research. Additional care must be exercised to ensure instrument and reagent controls are utilized appropriately. Complete graphical analysis of positive and negative signal intensities, concentration, and separation or stain index data is highly beneficial when paired with visual analysis of the cytometry data. Using analytical flow cytometry procedures optimized for cells for EV analysis can lead to misleading and nonreproducible results.
Multigram Synthesis of α‐ and γ‐((Hetera)cyclo)alkylpyridines through α‐Arylation of (Hetero)aliphatic Nitriles
Authors: Sierov Dmytro I. , Dzhulai Illia V. , Siryk Kateryna I. , Shvydenko Kostiantyn V. , Shvydenko Tetiana I. , Nazarenko Kostiantyn , Kostyuk Aleksandr , Liashuk Oleksandr S. , Grygorenko Oleksandr O. 
Published: June 2023

AbstractA systematic study on the SnAr reaction of halogenated fluoropyridines and (hetero)aliphatic nitrile anions as an approach to the synthesis of functionalized pyridines bearing a (cyclo)alkyl or saturated heterocyclic substituent by is described. The scope of the method was demonstrated on a wide range of (hetero)aliphatic nitriles (including three‐ to six‐membered cycloalkane derivatives and N‐, O‐, S‐containing saturated heterocycles) and all isomeric halogenated 2‐and 4‐fluoropyridines. High chemo‐ and regioselectivity (i. e., exclusive substitution of the fluorine atom), as well as excellent scalability of the proposed reaction sequence were demonstrated (up to 450 g for the arylation step or up to 77 g of cycloalkylpyridine over two steps in a single run). The utility of the synthesized products was illustrated in the additional functional group transformations resulting in synthetically valuable pyridine‐containing building blocks.
A Critical Review of Amphibian Per- and Polyfluoroalkyl Substance Ecotoxicity Research Studies: Identification of Screening Levels in Water and Other Useful Resources for Site-Specific Ecological Risk Assessments
Authors: Pandelides Zacharias , Conder Jason , Choi Youn , Allmon Elizabeth , Hoskins Tyler , Lee Linda , Hoverman Jason , Sepúlveda Maria 
Published: June 2023

Abstract
With the goal of aiding risk assessors conducting site-specific risk assessments at per- and polyfluoroalkyl substance (PFAS)-contaminated sites, this critical review synthesizes information on the ecotoxicity of PFAS to amphibians in 10 amphibian species and 16 peer-reviewed publications. The studies in this review consisted of spiked-PFAS chronic toxicity experiments with perfluorooctane sulfonate (PFOS), perfluorooctanoic acid (PFOA), perfluorohexane sulfonate (PFHxS), and 6:2 fluorotelomer sulfonate (6:2 FTS) that evaluated apical endpoints typical of ecological risk-based decision making (survival, growth, and development). Body mass was the most sensitive endpoint, showing clear and biologically meaningful population level adverse effect sizes (≥20% adverse effects). From these results, we recommend chronic no observed effect concentration (NOEC) screening levels of 590 µg/L for PFOS and 130 µg/L for PFOA. At or above recommended chronic lowest observed effect concentration screening levels of 1100 µg/L PFOS and 1400 µg/L PFOA, there is an increased chance of adverse biologically relevant chronic effects. Biologically relevant adverse effects were not observed for PFHxS and 6:2 FTS, so unbounded NOECs of 1300 µg/L PFHxS and 1800 µg/L 6:2 FTS are recommended. Screening levels are also provided for the concentration of PFAS in an amphibian diet, amphibian tissue, and moss substrate. In addition, we recommend bioconcentration factors that can be useful to predict concentrations of PFAS in amphibians using concentrations in water; these values are useful for food web modeling to understand risks to vertebrate wildlife that prey on amphibians. Overall, the present study provides a guide to the wealth of ecotoxicological research on PFAS conducted by our research group and highlights the need for additional work that would improve the understanding of chemical risks to amphibians. Environ Toxicol Chem 2023;42:2078–2090. © 2023 SETAC
Machine learning in computational histopathology: Challenges and opportunities
Authors: Cooper Michael , Ji Zongliang , Krishnan Rahul G. 
Published: June 2023

AbstractDigital histopathological images, high‐resolution images of stained tissue samples, are a vital tool for clinicians to diagnose and stage cancers. The visual analysis of patient state based on these images are an important part of oncology workflow. Although pathology workflows have historically been conducted in laboratories under a microscope, the increasing digitization of histopathological images has led to their analysis on computers in the clinic. The last decade has seen the emergence of machine learning, and deep learning in particular, a powerful set of tools for the analysis of histopathological images. Machine learning models trained on large datasets of digitized histopathology slides have resulted in automated models for prediction and stratification of patient risk. In this review, we provide context for the rise of such models in computational histopathology, highlight the clinical tasks they have found success in automating, discuss the various machine learning techniques that have been applied to this domain, and underscore open problems and opportunities.
Forage breeding and cultivar development: A 50‐year perspective
Authors: Bouton Joseph Henry 
Published: June 2023

AbstractThis article represents the perspective of one retired, academic forage breeder and cultivar developer after 50 years of working experience. Developing cultivars that help farmers within pastoral agriculture is the main goal, a system where livestock is the consumer. International Grassland Congress proceedings, as well as the general literature, are historical guides for the state of forage breeding. Efficiency was achieved through technologies; better equipment for planting and harvesting; and advances in computer computation and communication. Biotechnology achievements were fitful and continue to evolve. Cultivar performance mean‐reversion, cost to the program, and what the farmer seed buyer was willing to pay are important considerations for applying any technology, especially biotechnologies. Biotech promises were too optimistic. This was due, in part, to a lack of understanding that traditional phenotypic/genotypic field selection programs operate in a complex way with multiple species and several traits screened simultaneously at a modest cost. The majority of current forage cultivars are from field‐based selection. Industry participation at scientific conferences declined over time, with less sharing of information the result. Cultivar developers will continue using basic field selection methods but should explore applying any technology; just be clever on when, how, and with whom to use them. Practical advice and experiences are also presented and discussed.
How the human resource (HR) function adds strategic value: A relational perspective of the HR function
Authors: Jo Jinhwan , Chadwick Clint , Han Joo Hun 
Published: June 2023

AbstractIn the present article, we propose the concept of the HR function's relational activities and examine its influence on the firm's human capital resources (HCRs) and performance. Integrating insights from various streams of research in strategic human resource management (HRM) and strategic human capital, we develop a relational perspective of the HR function and propose the relational activities as the HR function's advisory and informative activities toward its internal stakeholders (i.e., line managers, employees, and senior managers) to help the stakeholders meet their goals and needs. In our framework, we theorize how the HR function's relational activities lead to superior firm performance by enhancing the firm's HCRs and identify the firm's strategic HR systems and human capital losses as factors that complement and necessitate the HR function's relational activities, respectively. Using a five‐wave, nationally representative panel dataset covering 1415 firm observations, we find robust support for our hypotheses: the HR function's relational activities were positively related to HCRs, which was more pronounced when coupled with high levels of strategic HR systems and human capital losses. The HCRs, in turn, transmitted the effects of the relational activities on the firm's subsequent operational and financial performance. Overall, these findings develop strategic HRM theory by contributing a more comprehensive conceptualization of the HR function's role in the strategic HRM process and by revealing its effects on firm performance along with key moderators.
YES‐associated protein‐regulated Smad7 worsen epithelial barrier injury of chronic sinusitis with nasal polyps
Authors: Jiang Xiaocong , Shu Longlan , Liu Yijun , Shen Yang , Ke Xia , Liu Jie , Yang Yucheng 
Published: June 2023

AbstractBackgroundChronic rhinosinusitis with nasal polyps (CRSwNP) was potentially due to the epithelial barrier injury. YES‐associated protein (YAP) is a multifunctional transcriptional factor and plays versatile roles in the regulation and maintenance of epithelial barrier in different organs and tissues. The purpose of this study is to elucidate possible effect and mechanism of YAP on the epithelial barrier of CRSwNP.MethodsPatients were divided into CRSwNP group (n = 12) and control group (n = 9). The location of YAP, PDZ‐binding transcriptional co‐activator (TAZ), and Smad7 were estimated by immunohistochemistry and immunofluorescence. Meanwhile, the expression of YAP, TAZ, Zona occludens‐1 (ZO‐1), E‐cadherin, and transforming growth factor‐beta1 (TGF‐β1) were detected by Western blot. After primary human nasal epithelial cells were treated with YAP inhibitor, the expression level of YAP, TAZ, ZO‐1, E‐cadherin, TGF‐β1, and Smad7 were measured by Western blot.ResultsCompared with the control group, the protein levels of YAP, TAZ, and Smad7 were significantly upregulated, while TGF‐β1, ZO‐1, and E‐cadherin were downregulated in CRSwNP. YAP and Smad7 demonstrated lower levels, while the expression of ZO‐1, E‐cadherin, and TGF‐β1 rose slightly after YAP inhibitor treatment in primary nasal epithelial cells.ConclusionsHigher level of YAP may lead to CRSwNP epithelial barrier injury via the TGF‐β1 signaling pathway, and the inhibition of YAP can partially reverse epithelial barrier function.
The finance–inequality nexus in the era of financialisation: Evidence for Portugal
Authors: Barradas Ricardo , Lakhani Rishi 
Published: June 2023

AbstractSince the 1980s, Portuguese policy makers have engaged in a strong process of liberalization, deregulation and privatization of the financial system to adhere to the rules imposed by the European Economic Community and to promote financial growth, boost economic growth and reduce inequality. However, the Portuguese economic growth has exhibited a weaker performance and inequality has continued to widen in the last decades, a situation that seems to contradict the mainstream beliefs regarding the supportive role played by financial growth in the era of financialisation. This article undertakes an empirical assessment of the finance–inequality nexus by performing a time series econometric analysis for Portugal from 1980 to 2020 through the estimation of both linear and non‐linear models. It finds strong evidence for a positive (linear) relationship between finance and inequality and some evidence for a convex quadratic (non‐linear) relationship between finance and inequality in Portugal, corroborating the hypothesis that the financial growth has been prejudicial, enhancing inequality in Portugal. These findings highlight the urgent need to abandon the so‐called ‘trickle‐down theory’ or the ‘horse and sparrow theory’ and to implement the so‐called ‘trickle‐up theory’ with the support of pro‐poor public policies to decrease inequality in Portugal.
Application of autoantibody detection in chronic liver disease
Authors: Han Jinyu , Chen Jin , Wang Yajie 
Published: June 2023

AbstractAutoantibody (AAb) detection has become one of the standards of diagnosis for autoimmune liver disease (AILD), and some AAbs have become specific biomarkers of AILD. In addition, AAbs can be detected in patients with non‐AILDs, such as viral hepatitis and alcoholic liver disease. However, the distribution characteristics and pathogenic mechanisms of AAbs in patients with non‐AILD are unclear. This article summarizes the characteristics of AAbs in several common clinical chronic liver diseases (CLDs) and discusses the value of AAb analysis in CLD.
Toxicological effects of selenium nanoparticles in laboratory animals: A review
Authors: Ryabova Yuliya V. , Sutunkova Marina P. , Minigalieva Ilzira A. , Shabardina Lada V. , Filippini Tommaso , Tsatsakis Aristides 
Published: June 2023

AbstractThis paper provides a comprehensive summary of the main toxicological studies conducted on selenium nanoparticles (NPs) using laboratory animals, up until February 28, 2023. A literature search revealed 17 articles describing experimental studies conducted on warm‐blooded animals. Despite some uncertainties, in vivo studies have demonstrated that selenium NPs have an adverse effect on laboratory animals, as evidenced by several indicators of general toxic action. These effects include reductions of body mass, changes in hepatotoxicity indices (increased enzyme activity and accumulation of selenium in the liver), and the possibility of impairment of fatty acid, protein, lipid, and carbohydrate metabolisms. However, no specific toxic action attributable solely to selenium has been identified. The LOAEL and NOAEL values are contradictory. The NOAEL was 0.22 mg/kg body weight per day for males and 0.33 mg/kg body weight per day for females, while the LOAEL was assumed to be a dose of 0.05 mg/kg of nanoselenium. This LOAEL value is much higher for rats than for humans. The relationship between the adverse effects of selenium NPs and exposure dose is controversial and presents a wide typological diversity. Further research is needed to clarify the absorption, metabolism, and long‐term toxicity of selenium NPs, which is critical to improving the risk assessment of these compounds.
The Multifarious Functions of Leukotrienes in Bone Metabolism
Authors: Amadeu de Oliveira Flávia , Tokuhara Cintia K. , Veeriah Vimal , Domezi João Paulo , Santesso Mariana R. , Cestari Tania M. , Ventura Talita M.O. , Matos Adriana A. , Dionísio Thiago , Ferreira Marcel R. , Ortiz Rafael C. , Duarte Marco A.H. , Buzalaf Marília A.R. , Ponce José B. , Sorgi Carlos A. , Faccioli Lucia H. , Buzalaf Camila Peres , de Oliveira Rodrigo Cardoso 
Published: June 2023

ABSTRACTLeukotrienes (LTs) are derived from arachidonic acid metabolism by the 5‐lipoxygenase (5‐LO) enzyme. The production of LTs is stimulated in the pathogenesis of rheumatoid arthritis (RA), osteoarthritis, and periodontitis, with a relevant contribution to bone resorption. However, its role in bone turnover, particularly the suppression of bone formation by modulating the function of osteoclasts and osteoblasts, remains unclear. We investigated the effects of LTs on bone metabolism and their impact on osteogenic differentiation and osteoclastogenesis using a 5‐LO knockout (KO) mouse model. Results from micro‐computed tomography (μCT) analysis of femur from 8‐week‐old 5‐LO‐deficient mice showed increased cortical bone and medullary region in females and males and decreased trabecular bone in females. In the vertebra, we observed increased marrow area in both females and males 5‐LO KO and decreased trabecular bone only in females 5‐LO KO. Immunohistochemistry (IHC) analysis showed higher levels of osteogenic markers tissue‐nonspecific alkaline phosphatase (TNAP) and osteopontin (OPN) and lower expression of osteoclastogenic marker tartrate‐resistant acid phosphatase (TRAP) in the femurs of 5‐LO KO mice versus wild‐type (WT). Alkaline phosphatase activity and mineralization assay results showed that the 5‐LO absence enhances osteoblasts differentiation and mineralization but decreases the proliferation. Alkaline phosphatase (ALP), Bglap, and Sp7 gene expression were higher in 5‐LO KO osteoblasts compared to WT cells. Eicosanoids production was higher in 5‐LO KO osteoblasts except for thromboxane 2, which was lower in 5‐LO–deficient mice. Proteomic analysis identified the downregulation of proteins related to adenosine triphosphate (ATP) metabolism in 5‐LO KO osteoblasts, and the upregulation of transcription factors such as the adaptor‐related protein complex 1 (AP‐1 complex) in long bones from 5‐LO KO mice leading to an increased bone formation pattern in 5‐LO–deficient mice. We observed enormous differences in the morphology and function of osteoclasts with reduced bone resorption markers and impaired osteoclasts in 5‐LO KO compared to WT osteoclasts. Altogether, these results demonstrate that the absence of 5‐LO is related to the greater osteogenic profile. © 2023 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research (ASBMR).