bluuebunny/crossref_metadata_2025_split huggingface dataset:
Monitoring the appropriate prescription of low molecular weight heparins and Fondaparinux through administrative data. A retrospective observational study in the Tuscany region
Authors: Moretti Giaele , Vinci Bruna , Zito Simona , Caputo Alessia , Attanasio Francesco , Vainieri Milena 
Published: September 2023

Introduction
Low Molecular Weight Heparins (LMWHs) and Fondaparinux have been widely used as anticoagulants. Mass prescription may lead to prescriptive inappropriateness, which causes Heparin-induced thrombocytopenia and other side effects.

Objectives
The study investigates the appropriate prescription of LMWHs and Fondaparinux in Tuscany. We aim to validate the crude measure of prescription appropriateness of the Key Performance Indicator (KPI) “Patients treated with LMWHs and Fondaparinux every hundred residents in Tuscany” as a proxy for monitoring prescription appropriateness.

Methods
To compare a crude KPI based only on drug consumption with a refined KPI based on exclusions listed in the clinical guidelines, a retrospective observational cohort study was carried out, using the RECORD guidelines for the year 2019. The refined indicator is computed via record linkage of different datasets regarding (a) pharmaceutical services; (b) hospital discharge records; (c) outpatient services; and (d) birth certificates. We apply exclusion criteria to identify the cohort of patients. Values of the KPI are compared, by ranking, with those obtained from its refined version. A Spearman test was performed to validate the use of the crude KPI as a proxy.

Results
208,717 LMWH and Fondaparinux users are identified, of which 103,299 fall within the study’s inclusion criteria. 16,817 (16%) of LMWHs and Fondaparinux users are classified as high consumption. The refined version of the KPI produces the same ranking results in terms of local health districts (rho = 0.98 p<0.01).

Conclusions
Although the crude KPI is less refined and detailed than the adjusted indicator computed by our study, it has proven capable to provide an accurate snapshot of the use of these drugs across the region. This analysis is useful to enable regional and local managers to run rapid and simple indicators to monitor the appropriateness of LMWHs and Fondaparinux. This analysis should be reviewed periodically to confirm its accuracy.
Performance analysis of hybrid PV-diesel-storage system in AGRS-Hassi R’mel Algeria
Authors: Mahmoudi Ahssen , Bouaziz Amina Manel , Bouaziz Mohamed Najib , Saheb-Koussa Djohra 
Published: September 2023

The main research paper focuses on the optimal hybrid system using HOMER software in the central plant of Hassi R’mel. Indeed, the system is composed of PV panels, a battery bank, and a diesel engine, all of which are used to supply an industrial load. Hence, the present work proposes a solution to optimize the power generated by the power sources, maximize the photovoltaic source use, and minimize the use of the battery bank and the diesel generator. Moreover, the solution aims to guarantee the safe operation of the system components and continuity in the load power supply. These objectives are performed by the minimization of a cost function, in which the power generation cost, the energetic balance, and the environmental parameters are taken into consideration. Among the five solutions, the most optimal system obtained is PV/Diesel/batteries /Grid. This system consists of 1200 KW PV, an 1100 KW diesel generator, 800 units of battery, and an 1100 KW converter. Therefore, to supply the station with 49% of electricity by PV and 51% by diesel while the reduction of emissions is 60%, and 708020 liters of diesel is saved. Applying the sensitivity analysis also showed that renewable resources have an impact on the sizing of PV. When solar radiation increases, the size of renewable energy decreases and the NPC decreases as well. It can, thus, be illustrated that the PV/diesel/battery system is not fully-optimal. This strategy is recommended for industrial system security since it can be used to ensure systems from an energetic and economic point of view.
PPARG stimulation restored lung mRNA expression of core clock, inflammation‐ and metabolism‐related genes disrupted by reversed feeding in male mice
Authors: Shlykova Oksana , Izmailova Olga , Kabaliei Alina , Palchyk Vitalina , Shynkevych Viktoriya , Kaidashev Igor 
Published: September 2023

AbstractThe circadian rhythm system regulates lung function as well as local and systemic inflammations. The alteration of this rhythm might be induced by a change in the eating rhythm. Peroxisome proliferator‐activated receptor gamma (PPARG) is a key molecule involved in circadian rhythm regulation, lung functions, and metabolic processes. We described the effect of the PPARG agonist pioglitazone (PZ) on the diurnal mRNA expression profile of core circadian clock genes (Arntl, Clock, Nr1d1, Cry1, Cry2, Per1, and Per2) and metabolism‐ and inflammation‐related genes (Nfe2l2, Pparg, Rela, and Cxcl5) in the male murine lung disrupted by reversed feeding (RF). In mice, RF disrupted the diurnal expression pattern of core clock genes. It decreased Nfe2l2 and Pparg and increased Rela and Cxcl5 expression in lung tissue. There were elevated levels of IL‐6, TNF‐alpha, total cells, macrophages, and lymphocyte counts in bronchoalveolar lavage (BAL) with a significant increase in vascular congestion and cellular infiltrates in male mouse lung tissue. Administration of PZ regained the diurnal clock gene expression, increased Nfe2l2 and Pparg expression, and reduced Rela, Cxcl5 expression and IL‐6, TNF‐alpha, and cellularity in BAL. PZ administration at 7 p.m. was more efficient than at 7 a.m.
The Failure of a Pure Patent Market
Authors: Bessy Christian 
Published: September 2023

Abstract
This paper presents an analysis of the movement to make patents a new asset class, and its relative failure. Our thesis is that this creation is largely dependent on the construction of a market devoted to transactions in patents, and not just in technology licenses, and on the emergence of new intellectual property intermediaries akin to finance, whose activity must nevertheless be regulated. Our analysis is based on the various patent valuation conventions that underpin its institutionalization and the variety of its uses.
Translingual practice as a representation of heritage languages and regional identities in multilingual society
Authors: Ding Seong Lin , Goh Kim Leng 
Published: September 2023

Abstract
By drawing attention to the translingual practices in Malaysian Mandarin (MM), this study uses lexical variations as an analytical lens through which the changes in linguistic dimensions can be viewed from a social perspective. We present translingual practice as a communicative, rather than a pedagogical, resource that has broader applied relevance in multilingual society. Two findings are presented. First, we elaborate on how MM is interwoven with translingual words of various heritage languages (HLs)/dialects and major/powerful languages; second, we examine how translingual words varied from or standardised towards Standard Mandarin (SM) over time, by HL and in place/region. We argue that intersection with competing levelling pressures reflects not only a “standardisation” process at schools/in society but can be further interpreted as the decline of local translingual practices and local sounds, suggesting the risk of losing rich ethnic and regional heritage and identities. By giving a voice to marginalised HL speakers, this study goes beyond the description of an unstudied/understudied research site or linguistic phenomenon, implying important aspects of power and inequality and a subtle resistance against dominant policies/discourses. This could be salient for advancing future studies and theories to address efforts in advocating critical language awareness and inclusive policies.
Answerability in computer-assisted language learning: a critical examination of social justice research from a decolonial perspective
Authors: Dizon Gilbert 
Published: September 2023

Abstract
In this conceptual article, the author introduces decolonization as an alternative to social justice frameworks. As stakeholders in second language (L2) teaching, the author stresses decolonization as a means for L2 researchers to work against colonial practices in educational research, which negatively impact historically disenfranchised communities. Specifically, Patel’s (Patel, Leigh. 2016. Decolonizing educational research: From ownership to answerability. New York: Routledge) answerability framework is introduced as a practical method to support decolonization in L2 research. The article is made up of four main sections. The first section explains the concept of settler colonialism and highlights how it is ingrained in educational research. In the second section, the author defines decolonization and distinguishes it from the more popular social justice movement. In the third section, the author summarizes four computer-assisted language learning (CALL) papers which were featured in a recent special issue on the topic of social justice. The author then provides a critical analysis of the reviewed studies from a decolonial perspective in the fourth and final section, while also suggesting ways in which researchers and educators can re-orient their work towards decolonization.
A structural biology view on the enzymes involved in eukaryotic mRNA turnover
Authors: Krempl Christina , Lazzaretti Daniela , Sprangers Remco 
Published: September 2023

Abstract
The cellular environment contains numerous ribonucleases that are dedicated to process mRNA transcripts that have been targeted for degradation. Here, we review the three dimensional structures of the ribonuclease complexes (Pan2-Pan3, Ccr4-Not, Xrn1, exosome) and the mRNA decapping enzymes (Dcp2, DcpS) that are involved in mRNA turnover. Structures of major parts of these proteins have been experimentally determined. These enzymes and factors do not act in isolation, but are embedded in interaction networks which regulate enzyme activity and ensure that the appropriate substrates are recruited. The structural details of the higher order complexes that form can, in part, be accurately deduced from known structural data of sub-complexes. Interestingly, many of the ribonuclease and decapping enzymes have been observed in structurally different conformations. Together with experimental data, this highlights that structural changes are often important for enzyme function. We conclude that the known structural data of mRNA decay factors provide important functional insights, but that static structural data needs to be complemented with information regarding protein motions to complete the picture of how transcripts are turned over. In addition, we highlight multiple aspects that influence mRNA turnover rates, but that have not been structurally characterized so far.
Artificial intelligence technologies and applications for language learning and teaching
Authors: Son Jeong-Bae , Ružić Natasha Kathleen , Philpott Andrew 
Published: September 2023

Abstract
Artificial intelligence (AI) is changing many aspects of education and is gradually being introduced to language education. This article reviews the literature to examine main trends and common findings in relation to AI technologies and applications for second and foreign language learning and teaching. With special reference to computer-assisted language learning (CALL), the article explores natural language processing (NLP), data-driven learning (DDL), automated writing evaluation (AWE), computerized dynamic assessment (CDA), intelligent tutoring systems (ITSs), automatic speech recognition (ASR), and chatbots. It contributes to discussions on understanding and using AI-supported language learning and teaching. It suggests that AI will be continuously integrated into language education and AI technologies and applications will have a profound impact on language learning and teaching. Language educators need to ensure that AI is effectively used to support language learning and teaching in AI-powered contexts. More rigorous research on AI-supported language learning and teaching is recommended to maximise second and foreign language learning and teaching with AI.
Crystal structure of bis(dimethylammonium) poly[(μ4-1,1′-(1,4-phenylenebis(methylene))bis(1H-pyrazole-3,5-dicarboxylato))-κ6
O
1, N
2:O
2:O
3:O
1′,N
2′]nickel (II)], C22H26N6NiO8
Authors: Li Fenfang 
Published: September 2023

Abstract
C22H26N6NiO8, monoclinic, P21/n (no. 14), a = 10.9372(7) Å, b = 10.4567(6) Å, c = 11.7618(7) Å, β = 116.5552(19)°, V = 1203.25(13) Å3, Z = 2, R

gt
(F) = 0.0406, wR

ref
(F
2) = 0.1089, T = 297(2) K.
Crystal structure of (2S,3S,4S,5S, Z)-2,3,5,6-tetrakis(benzyloxy)-4-hydroxyhexanal oxime, C34H37NO6
Authors: Zhang Nuo , Guo Shuo-Nan , Du Liang-Qi , Ren Xiao-Yu 
Published: September 2023

Abstract
C34H37NO6, triclinic, P1̄ (no. 2), a = 6.398(6) Å, b = 10.779(10) Å, c = 12.030(11) Å, α = 71.103(10)°, β = 89.519(11)°, γ = 74.154(11)°, V = 752.2(12) Å3, Z = 1, R

gt
(F) = 0.0599, wR

ref
(F2) = 0.1614, T = 296 K.
Herausforderung beim Einsatz von grünem Wasserstoff
Authors: Mais Franziska , Gramberg Till , Jelschow Vladimir , Groß Erwin , Sauer Alexander 
Published: September 2023

Abstract
Das Projekt „H2Wood – Black Forest“ untersucht den möglichen Einsatz von grünem Wasserstoff in den Sektoren Verkehr, Industrie sowie Haushalte und Gebäude in der Region Schwarzwald. In einer qualitativen Expert:innen-Befragungen wurden Barrieren und Hemmnisse in den Bereichen Infrastruktur, politischer Rahmen, Markt sowie Forschung und Entwicklung identifiziert. Die Ergebnisse geben Aufschluss über zukünftig notwendige Maßnahmen zum erfolgreichen Einsatz von grünem Wasserstoff.
Strength and Durability Assessment of Self-Healing Bio-Based Composite Concrete under Different Exposure Conditions
Authors: Rajesh A. , Sumathi A. , Gowdhaman D. 
Published: September 2023

Abstract
Cracks in concrete are predestined, and they lay a pathway for water and aggressive chemical substances, which leads to deterioration of concrete ingredients and affects the service life of concrete structures. In the recent years, natural fibers and bacteria species are used to improve rheological properties and to heal concrete cracks. Precipitation of calcium carbonate crystals produced by bacteria in concrete cracks is highly acceptable to increase the mechanical and durability properties. In this research, Bacillus paramycoides species is isolated from concrete efflorescence and is used for self-healing. For bacteria immobilization, natural fibers like coir, flax, and jute are used as suitable carriers. Furthermore, the study on the performance of bacteria in crack healing and strengthening properties is in need for different curing/exposure conditions such as full-wet, wet–dry, saturated normal soil, and saturated marine soil. The performance of bacteria in concrete is estimated by a series of tests such as compressive strength, compressive strength regains, tensile strength, impact strength, sorptivity, and deterioration of concrete under acid curing. Based on the test results, the selected bacteria have the ability to heal crack widths of 0.3–1.1 mm with the average healing rate of 83 %, 92 %, 76 %, and 42.5 % for full-wet, wet–dry, normal soil, and marine soil exposure, respectively. Microstructure studies were investigated for fiber-reinforced concrete and bacteria-immobilized fiber-reinforced concrete to determine the composition of elements formed in calcium carbonate precipitates. In this work, the results suggest that natural fibers can be used as sustainable carrier material for crack healing, strength, and durability improvement in concrete.
Evaluation and Testing of Carbonation Behavior of Sprayed Concrete with Different Liquid Accelerators
Authors: Yang Renhe , Zhang Pengyu , Wang Dongmei , Sun Qian , He Tingshu 
Published: September 2023

Abstract
This article mainly tested and evaluated the carbonation resistance of sprayed concrete mixed with different liquid accelerators, and thus attempted to establish a prediction model for the carbonation depth of sprayed concrete. Firstly, the influence of alkaline liquid accelerator based on sodium aluminate (AR), alkaline-free liquid accelerator based on aluminum sulfate (AS), and alkali-free liquid accelerator based on fluoroaluminate (AF) on carbonation resistance of sprayed concrete was explored. In addition, the porosity and pore structure distribution of ordinary sprayed concrete (OSC), sprayed concrete with AR (SC-AR), sprayed concrete with AS (SC-AS), and sprayed concrete with AF (SC-AF) were analyzed by the mercury intrusion porosimetry. The carbonation depth and compressive and splitting tensile strength also were tested. Furthermore, the scanning electron microscopy was employed to observe the micromorphology of hydration products. The experimental results indicated that the carbonation depth order of sprayed concrete was as follows: SC-AR &gt; SC-AF &gt; SC-AS &gt; OSC. After analyzing the disparity of SC-AR, SC-AS, and SC-AF carbonation depth caused by AR, AS, and AF dosage, the influence coefficients of sprayed concrete carbonation depth were introduced. Finally, the carbonation depth prediction models of SC-AR, SC-AS, and SC-AF were preliminarily established.
The Impact of Chemical Fixation on the Microanatomy of Mouse Organotypic Hippocampal Slices
Authors: Idziak Agata , Inavalli V. V. G. Krishna , Bancelin Stéphane , Arizono Misa , Nägerl U. Valentin 
Published: September 2023

AbstractChemical fixation using paraformaldehyde (PFA) is a standard step for preserving cells and tissues for subsequent microscopic analyses such as immunofluorescence or electron microscopy (EM). However, chemical fixation may introduce physical alterations in the spatial arrangement of cellular proteins, organelles, and membranes. With the increasing use of super-resolution microscopy to visualize cellular structures with nanometric precision, assessing potential artifacts, and knowing how to avoid them, takes on special urgency. We addressed this issue by taking advantage of live-cell super-resolution microscopy that makes it possible to directly observe the acute effects of PFA on organotypic hippocampal brain slices, allowing us to compare tissue integrity in a “before-and-after” experiment. We applied super-resolution shadow imaging (SUSHI) to assess the structure of the extracellular space (ECS) and regular super-resolution microscopy of fluorescently labeled neurons and astrocytes to quantify key neuroanatomical parameters. While the ECS volume fraction (VF) and microanatomic organization of astrocytes remained largely unaffected by the PFA treatment, we detected subtle changes in dendritic spine morphology and observed substantial damage to cell membranes. Our experiments show that PFA application via immersion does not cause a noticeable shrinkage of the ECS in hippocampal brain slices maintained in culture, unlike the situation in transcardially perfused animalsin vivowhere the ECS typically becomes nearly depleted. Our study outlines an experimental strategy to evaluate the quality and pitfalls of various fixation protocols for the molecular and morphologic preservation of cells and tissues.
Development of Photomyxotrophic Culture Protocol of Lemongrass Through Sucrose Concentration Increase and Light Intensity Decrease
Authors: Irmawati Desy , Rahayu Enni Suwarsi 
Published: September 2023

Lemongrass (Cymbopogon nardus (L.) Randle) plantlets are interesting to be used as tissue culture-based souvenir. The success of plantlet propagation through photomyxotrophic culture is influenced by several factors, including sucrose concentration and light intensity. The research aimed to analyze the effect of sucrose concentration and light intensity on the growth of lemongrass plantlets. This experimental research used randomized block factorial design with two factors, namely sucrose concentration (0 g/l, 10 g/l, 20 g/l, 30 g/l) and light intensity (2000 lux, 3000 lux, 4000 lux, 5000 lux). The variables observed were some parameters of growth and development of plantlet. The data were analyzed with two-way Analyses of Variance and Duncan Multiple Range Test. The results showed that sucrose concentration had significant effect on the number of shoots and leaves of plantlet. The light intensity and the interaction of both factors had also significant effect on the number of shoots and leaves. The most optimal treatments were sucrose of 20 g/l and light intensity of 3000 lux. The results of this study innovate the tissue culture technique using photomyxotrophic system in order to produce sterile lemongrass plantlets in large quantities.
Antioxidant Activity and Phytochemical of Ocimum basilicum to Strengthen the Traditional Balinese Medicine System
Authors: Arsana I Nyoman , Ayu Juliasih Ni Ketut , Ayu Sauca Sunia Widyantari A. A. 
Published: September 2023

The system of traditional Balinese medicine is known as Usada. One type of plant used in Usada is basil (Ocimum basilicum L). Antioxidant activity and phytochemical of ethanol extracts of two varieties of basil, Ocimum basilicum L (var.) Bali (OcB) and Ocimum basilicum L (var.) Lombok (OcL) was investigated. Total phenol was determined by folin-cioccalteu phenol reagent, total flavonoid by quarsetine reagent, tannin by Folin-Denis reagent, and antioxidant activity was determined using the 2,2-diphenyl-1-picrylhydrazyl radical scavenging method and is expressed as IC50. All of the parameters were measured by spectrophotometer. Phytochemicals were determined by Gas chromatography and mass spectrometry (GC-MS) Analysis. Morphological characters (stems, leaves, and flowers) are also observed. The results showed, in OcB obtained 92 compounds, 10 of which are important compounds that have an antioxidant effect, while in OcL 139 compound components were found, 15 of which are important compounds. Levels of phenols, flavonoids, tannins, as well as IC50 in OcB are; 3526.65 mg GAE/100g, 15841.6795 mg QE/100g, 2402.80 mg/100 g, and 24.9410 mg/L, respectively, while in OcL respectively are; 3297.71 mg GAE/100g, 13242.30 mg QE/100g, 850.71 mg/100, and 33.1105 mg/L. Conclusions, morphologically OcB and OcL showed no difference except leaf width and petiole length. The antioxidant activity of OcB is better, as well as higher levels of phenols, flavonoids, and tannins compared to OcL.
Consumers Purchase Intention towards Solar Panel as Renewable Energy Source in Malaysia
Authors: Yew Lim Kim , Kowang Tan Owee , Yang MengXi , Jong Loh Chee 
Published: September 2023

Numerous studies have been undertaken, both globally and locally, to investigate influencing factors and consumer buying behaviour relationships. However, research on consumer purchase intention towards solar panel as renewable energy product in Malaysia is still lacking, and this research aims to fill the research gap. The objectives of this study to examine the factors influencing comprising of product price, product quality and advertising towards consumers’ purchase intention of solar panel in Malaysia. The data for this study were collected from 348 respondents via an online questionnaire, and hypotheses analysis was conducted using multiple regression analysis to investigate the influencing factors and consumers’ purchase intention for solar panel as renewable energy product in Malaysia. Results shown that product price, product quality and advertising have significant influence on consumers’ purchase intention towards solar panel in Malaysia as important source for energy conservation and generation.