bluuebunny/crossref_metadata_2025_split huggingface dataset:
The lived experiences of UK physiotherapists involved in Cauda Equina Syndrome litigation. A qualitative study
Authors: Yeowell Gillian , Leech Rachel , Greenhalgh Susan , Willis Emma , Selfe James 
Published: September 2023

Background
Cauda Equina Syndrome is a serious spinal pathology, which can have life changing physical and psychological consequences and is highly litigious. Litigation can have negative personal and professional effects on the healthcare professionals cited in a clinical negligence claim. There is an absence of research looking at the experience of the physiotherapist and as such, it is unknown the impact litigation is having on them. This study explored the lived experiences of UK physiotherapists in relation to Cauda Equina Syndrome litigation.

Methods
A qualitative design, informed by Gadamerian hermeneutic phenomenology, using semi-structured interviews was used to explore participants’ lived experiences of litigation. Interviews were audio-recorded and transcribed verbatim. Findings were analysed using an inductive thematic analysis framework. Nvivo software was used to facilitate analysis. The study is reported in accordance with the consolidated criteria for reporting qualitative (COREQ) research.

Results
40 interviews took place online or over the phone, with physiotherapists and stakeholders. Four themes were found; ‘litigation effects’, ‘it feels personal’, ‘learning from litigation’ and ‘support and training’.

Conclusion
This is the first study to investigate the lived experiences of litigation in UK physiotherapists. Involvement in clinical negligence affected physiotherapists’ physical and mental wellbeing and impacted their clinical practice. Most physiotherapists felt litigation was a personal attack on them and their ability to do their job. Physiotherapists highlighted perceptions of a ‘blame culture’ and perceived stigma associated with the claim, which often led to a lack of sharing and learning from litigation. Physiotherapists emphasised the need for emotional support for those going through a legal claim and that training was needed to understand the process of litigation and range of potential outcomes.
Job satisfaction of hospital pharmacists in a representative province in Mekong Delta, Vietnam
Authors: Tran Van De , Vo Thi My Loan , Nguyen Di Khanh , Vo Quang Loc Duyen , Dewey Rebecca Susan , Pham Trung Tin , Tran Ba Kien , Pham Duy Toan 
Published: September 2023

Background
Job satisfaction is an important factor affecting job performance and turnover of healthcare workers, especially hospital pharmacists. Nevertheless, limited studies have reported this issue in the context of Vietnam.

Objectives
To help maintain the quality and size of the limited hospital pharmacy workforce in Vietnam, especially in the Mekong Delta area, this study investigated the job satisfaction of hospital pharmacists, and the associated factors, in Vinh Long province, a representative province in the central Mekong Delta.

Methods
A cross-sectional survey was conducted, recruiting hospital pharmacists working in all 17 province/district-affiliated healthcare facilities across Vinh Long province, Vietnam, between August and September 2022.

Results
Among the 235 survey participants (representing a response rate of 97.1%), 189 pharmacists (80.4%) reported that they were satisfied with their job. Working conditions, leadership styles, and benefits were factors found to significantly influence job satisfaction. Pharmacists who had worked in the field for 3–5 years (OR = 3.752, 95% CI = 1.036–13.595), more than 5 years (OR = 6.361, 95% CI = 2.264–17.875), did not have additional duties besides their primary responsibilities (OR = 2.046, 95% CI = 1.005–4.163), and worked in a private healthcare facility (OR = 12.021, 95% CI = 1.470–98.316), were significantly more likely to be satisfied with their job.

Conclusions
Most hospital pharmacists were satisfied with their current job. To further improve job satisfaction in this population, further improvements to working conditions are necessary.
AMTASTM and user-operated smartphone research application audiometry—An evaluation study
Authors: Sørensen Chris Bang , Adams Thomas Bording , Pedersen Ellen Raben , Nielsen Jacob , Schmidt Jesper Hvass 
Published: September 2023

Objective
To evaluate two user-operated audiometry methods, the AMTASTM PC-based audiometry and a low-cost smartphone audiometry research application (R-App).

Design
A repeated-measures within-subject study design was used to compare both user-operated methods to traditional manual audiometry and to evaluate test-retest reliability of each method.

Study sample
58 subjects were recruited in the study of which 83 ears had normal hearing thresholds and 33 ears had hearing loss (pure-tone average > 25 dB HL). Average age of participants was 44.8 years, with an age range of 11–85.

Results
Standard deviation of absolute differences ranged between 3.9–6.9 dB on AMTASTM and 4.5–6.8 dB on the R-App. The highest variability was found at the 8000 Hz frequency (R-App and AMTASTM test) and 3000 Hz frequency (AMTASTM retest). Evaluation of test-retest reliability of AMTASTM and R-App showed SD of absolute differences ranging between 3.5–5.8 dB and 3.1–5.0 dB, respectively. The mean threshold difference between test and retest was within ±1.5 dB on AMTASTM and ±1 dB on the R-App.

Conclusion
Accuracy of AMTASTM and the R-App was within acceptable limits for audiometry and comparable to traditional manual audiometry on all tested frequencies (250–8000 Hz). Evaluation of test-retest reliability showed acceptable variation on both AMTASTM and R-App. Both user-operated methods could be reliably performed in a quiet non-soundproofed environment.
Pre-Exposure Prophylaxis and HIV Incidence
Authors: Mann Samuel 
Published: September 2023

Abstract
Pre-Exposure Prophylaxis (PrEP) is a drug that, as demonstrated in clinical trials, when taken makes the user virtually immune to HIV. This has led to numerous countries making the drug available, but little is known about the population level effects of PrEP. Using panel data from 40 European countries I study the effect of countries adopting WHO recommendations to make PrEP available to citizens. I demonstrate that PrEP availability leads to around 15–20 % fewer new HIV infections. My results indicate that PrEP can be an effective tool in reducing HIV incidence.
Genetic markers associated with adverse reactions of radioiodine therapy in thyroid cancer patients
Authors: Denisenko Natalia P. , Kachanova Anastasia A. , Sychev Ivan V. , Shuev Gregory N. , Perfilieva Oksana M. , Mukhamadiev Reis H. , Kazakov Ruslan E. , Milyutina Olga I. , Konenkova Olga V. , Ryzhkin Sergey A. , Zhmaeva Elena M. , Kirienko Sergey L. , Ivashchenko Dmitriy V. , Bure Irina V. , Ametov Alexander S. , Poddubnaya Irina V. , Mirzaev Karin B. , Sychev Dmitry A. 
Published: September 2023

Abstract

Objectives
Radioactive iodine therapy is considered for patients with certain clinicopathological factors that predict a significant risk of recurrence, distant metastases of thyroid cancer or disease-specific mortality. The aim of the study was to investigate the association between polymorphisms of genes, products of which are involved in the processes of DNA damage response and autophagy, and the adverse reactions of radioiodine therapy in thyroid cancer patients.

Methods
The study included 181 patients (37 men, 144 women; median age 56 [41; 66.3] years) with histologically confirmed thyroid cancer and a history of thyroidectomy who received radioiodine therapy. NFKB1, ATM, ATG16L2, ATG10, TGFB1, and TNF polymorphisms were determined by allele-specific realtime-PCR.

Results
The frequency of adverse reactions was the following: gastrointestinal symptoms – 57.9 %, local symptoms – 65.8 %, cerebral symptoms – 46.8 %, fatigue – 54.4 %; signs of sialoadenitis six months after radioiodine therapy – 25.2 %. TT genotype carriers of ATG10 rs1864183 had higher frequency of gastrointestinal symptoms (vs. CC+CT), the CC genotype carriers of ATG10 rs10514231 had significantly more frequent cerebral symptoms (vs. CT+TT), as well as AA genotype carriers of TGFB1 rs1800469 (vs. AG+GG). CC genotype of ATG10 rs10514231 increased the incidence of radioiodine-induced fatigue, whereas GA genotype of the ATM rs11212570 had a protective role against fatigue. TGFB1 rs1800469 was associated with signs of sialoadenitis six months after radioiodine therapy.

Conclusions
Genetic factors may contribute to the occurrence of adverse reactions of radioiodine therapy in thyroid cancer patients.
The archaeal Lsm protein from Pyrococcus furiosus binds co-transcriptionally to poly(U)-rich target RNAs
Authors: Reichelt Robert , Rothmeier Tamara , Grünberger Felix , Willkomm Sarah , Bruckmann Astrid , Hausner Winfried , Grohmann Dina 
Published: September 2023

Abstract
Posttranscriptional processes in Bacteria include the association of small regulatory RNAs (sRNA) with a target mRNA. The sRNA/mRNA annealing process is often mediated by an RNA chaperone called Hfq. The functional role of bacterial and eukaryotic Lsm proteins is partially understood, whereas knowledge about archaeal Lsm proteins is scarce. Here, we used the genetically tractable archaeal hyperthermophile Pyrococcus furiosus to identify the protein interaction partners of the archaeal Sm-like proteins (PfuSmAP1) using mass spectrometry and performed a transcriptome-wide binding site analysis of PfuSmAP1. Most of the protein interaction partners we found are part of the RNA homoeostasis network in Archaea including ribosomal proteins, the exosome, RNA-modifying enzymes, but also RNA polymerase subunits, and transcription factors. We show that PfuSmAP1 preferentially binds messenger RNAs and antisense RNAs recognizing a gapped poly(U) sequence with high affinity. Furthermore, we found that SmAP1 co-transcriptionally associates with target RNAs. Our study reveals that in contrast to bacterial Hfq, PfuSmAP1 does not affect the transcriptional activity or the pausing behaviour of archaeal RNA polymerases. We propose that PfuSmAP1 recruits antisense RNAs to target mRNAs and thereby executes its putative regulatory function on the posttranscriptional level.
A proposed neural network model for obtaining precipitable water vapor
Authors: Al-Eshmawy Hadeer , Abdelfatah Mohamed A. , El-Fiky Gamal S. 
Published: September 2023

Abstract
The atmospheric Precipitable water vapor (PWV) is a variable key for weather forecasting and climate change. It is a considerable component of the atmosphere, influencing numerous atmospheric processes, and having physical characteristics. It can be measured directly using radiosonde stations (RS), which are not always accessible and difficult to measure with acceptable spatial and time precision. This study uses the artificial neural network (ANN) application to propose a simple model based on RS data to estimate PWV from surface metrological data. Ten RS stations were used to develop the new model for eight and a half years. In addition, two and a half years of data were used to validate the developed model. The study period is based on the data accessible between 2010 and 2020. The new model needs to collect (vapor pressure, temperature, latitude, longitude, height, day of year, and relative humidity) as input parameters in ANN to predict the PWV. The ANN model validations were based on the root mean square (RMS), correlation coefficient (CC), and T-test. According to the results, the proposed ANN can accurately predict the PWV over Egypt. The results of the new ANN model and eight other empirical models (Saastamoinen, Askne and Nordius, Okulov et al., Maghrabi et al., Phokate., Falaiye et al. (A&B), Qian et al. and ERA 5) are compared in addition, the new PWV model can achieve the best performance with RMS of 0.21 mm. The new model can serve as a will be of practical utility with a high degree of precision in PWV estimation.
Crystal structure of 2-(5-phenyl-1-(quinolin-2-yl)-4,5-dihydro-1H-pyrazol-3-yl)phenol, C24H19N3O
Authors: Zeng Dai , Tan Kai , Fang Ziyan , Xing Aiping 
Published: September 2023

Abstract
C24H19N3O, monoclinic, P21/c (no. 14), a = 10.4783(5) Å, b = 11.7171(5) Å, c = 14.9194(6) Å, β = 93.991(2)°, Z = 4, V = 1827.29(14) Å3, R
gt(F) = 0.0521, wR

ref
(F
2) = 0.1508, T = 150(2) K.
Energieeffizienz als Geschäftschance für den Maschinen- und Anlagenbau?
Authors: Rösler Jonathan , Lorenz Selina , Friedli Thomas , Palmié Maximilian 
Published: September 2023

Abstract
Angesichts steigender Energiekosten ist das Thema Energieeffizienz nicht erst seit heute von hoher Bedeutung für die in globaler Konkurrenz stehende produzierende Industrie. Maschinen- und Anlagenbauer versuchen, von der Nachfrage nach energieeinsparenden Lösungen zu profitieren. Paradoxerweise bleiben die erzielten Umsätze mit innovativen Paketen aus Hard- und Software sowie Services jedoch hinter den Erwartungen zurück. Auch der Versuch, Kunden mit neuen Geschäftsmodellen zu überzeugen, gelingt nicht in einem zufriedenstellenden Masse. Eine globale Befragung von Produktionsunternehmen offenbart die Gründe für dieses Phänomen aus Kundensicht und bietet gleichzeitig Ansatzpunkte, wie bestehende Barrieren durch die Anbieter überwunden werden können.
Thesen zur Konvergenz von Trends und Technologien in der Fabrikplanung
Authors: F. Schäfer Simon , Süße Marian , Ihlenfeldt Steffen 
Published: September 2023

Abstract
Die Fabrikplanung ist ein mehrdimensionales Aufgabengebiet und gegenwärtig mit dem Spannungsfeld aus Nachhaltigkeit, wirtschaftlicher Unsicherheit und kürzeren Technologiezyklen konfrontiert. Es werden kontinuierlich methodische Ansätze entwickelt und technologische Fortschritte in die Planungsprozesse integriert. Folglich entsteht der Eindruck, dass sich aktuelle Schlagworte in diesem Konglomerat zunehmend gegenseitig bedingen. In dem Beitrag werden zunächst diese Zusammenhänge grundlegend beschrieben und aktuelle Forschungstrends analysiert. Daran anknüpfend werden Thesen formuliert, die für eine interessierte Community als Diskussionsgrundlage dienen sollen. Abschließend werden die nächsten vermuteten Schritte zur Konvergenz der Trends und Technologien in der Fabrikplanung sowie zur Ableitung notwendiger Folgeinitiativen beschrieben.
Von der Transaktion zum Wert
Authors: Evcenko Dimitri , Kett Holger , Falkner Jürgen 
Published: September 2023

Abstract
Um ein wertbasiertes Geschäftsmodell im Sinne von Equipment-as-a-Service (EaaS) anbieten und betreiben zu können, muss ein Unternehmen spezifische EaaS-Elemente zu einem EaaS-Angebot zusammenführen. Der vom Fraunhofer-Institut für Arbeitswirtschaft und Organisation IAO entwickelte EaaS-Canvas stellt ein Werkzeug dar, mit dessen Hilfe diese EaaS-Elemente anhand eines strukturierten Vorgehens erarbeitet und visualisiert werden können, wobei die Elemente aus dem Veränderungsbedarf abgeleitet werden, der für Unternehmen entsteht, deren Leistungsangebot bisher ausschließlich auf transaktionsbasierten Geschäftsmodellen aufbaut. Im nachfolgenden Beitrag wird eine kurze Einführung in die einzelnen Elemente des EaaS-Canvas gegeben. Weiter wird die Erarbeitung eines EaaS-Angebots auf Basis des EaaS-Canvas schematisch anhand einer Transformation des transaktionalen Geschäftsmodells von TRUMPF Tracking Technologies (TRUMPF) durchgeführt.
Bewertung und Verbesserung des CO2-Fußabdrucks für PKW-Ladeeinrichtungen
Authors: Werrel Max , Becker Victor , Ehmsen Svenja , Tepper Florian , Glatt Moritz , Aurich Jan C. 
Published: September 2023

Abstract
Die Elektromobilität ist ein wichtiger Baustein für eine klimafreundliche Mobilität. Elektrofahrzeuge, insbesondere in Verbindung mit regenerativ erzeugtem Strom, können deutlich zu einer Reduktion der CO2-Bilanz des Mobilitätssektors beitragen. Im Rahmen einer ganzheitlichen Betrachtung gilt es jedoch, nicht nur das Fahrzeug selbst, sondern auch die notwendige Peripherie möglichst klimaschonend zu gestalten. In diesem Beitrag wird zu diesem Zweck die CO2-Bilanz von Ladeeinrichtungen über deren gesamten Lebenszyklus untersucht und Verbesserungspotenziale aufgezeigt.
Bewertung von Verfahren zum Erreichen von CO2-Negativität in der Produktion
Authors: Eboumbou Ebongue Yvonne , Sauer Alexander 
Published: September 2023

Abstract
Dieser Beitrag beschreibt verschiedene Verfahren zur CO2-Abscheidung aus der Umgebungsluft und zur CO2-Abtrennung aus Abgasen und bewertet sie hinsichtlich ihrer Reinheit, spezifischen Kosten zur CO2-Entfernung sowie des Platzbedarfs. Die betrachteten Verfahren umfassen CO2-Abtrennung aus Abgasen mittels Gaswäsche und Membranverfahren sowie CO2-Abscheidung aus der Umgebungsluft mittels Hochtemperatur- und Niedertemperatur-DAC-Verfahren. Es zeigt sich, dass die Kombination von CO2-Abtrennung aus Abgasen mittels Gaswäsche und gezielte Entfernung historisch emittierten CO2s aus der Umgebungsluft durch das Niedertemperatur-DAC-Verfahren entscheidend ist, um CO2-Negativität in der Produktion zu erreichen.
Feminismo contra a criminalização do aborto
Authors: Da Silva Ribeiro Gomes Simone , Do Prá Alano Roberta 
Published: September 2023

O artigo anali
sa as mobilizações de ativistas e coletivos feministas em El Salvador durante a
pandemia de Covid
-
19
–
notadamente no que se refere a direitos sexuais e reprodutivos
–
,
entre 2020 e 2022. O trabalho fez uso de metodologia qualitativa com entrevistas
semies
truturadas, estudo de caso e resgate de dados levantados nas edições do Comunica
América Latina, publicação do Observatório de Movimentos Sociais da América Latina
(OMSAL), entre julho de 2020 e fevereiro de 2022. O estudo de caso se dá a partir de dois
ep
isódios que chamaram a atenção para a situação dos direitos reprodutivos das mulheres
em El Salvador, país em que a proibição total do aborto é rigorosamente aplicada: os casos
Manuela e Beatriz. Duas jovens salvadorenhas expostas a violência obstétrica e
à legislação
antiaborto do país no início dos anos 2000. Os resultados apontam para um esforço dos
movimentos feministas salvadorenhos em resistir, no contexto de distanciamento social,
consequência de medidas sanitárias para combater o coronavírus, às tát
icas políticas
autoritárias do presidente Nayib Bukele. Ademais, as histórias de Manuela e Beatriz
mobilizaram importantes ações coletivas durante o período pandêmico e impactaram a
disputa pelo imaginário social a respeito do aborto no país.
As ruas e as urnas na pandemia
Authors: Henrique da Mota Ferreira Daniel , Luis Moreira Nascimento Jefferson , Nunes Raul 
Published: September 2023

O presente artigo procura
analisar o impacto da pandemia na relação entre os movimentos
sociais e as eleições no Equador e no Peru. Baseando
-
se na Teoria do Processo Político (TPP),
o artigo busca comparar, a partir da inflexão da pandemia, as semelhanças e diferenças que
podem hav
er na relação entre movimentos e eleições. Na primeira seção, apresentamos a TPP
e discutimos como as análises da economia política podem ajudar a pensar o
s
estallidos
da
América Latina. Na segunda e na terceira seção, descrevemos os processos políticos do
Equador e do Peru, respectivamente. Na quarta, fazemos a comparação entre os dois casos.
Como conclusão, apontamos que a pandemia acirrou clivagens já existentes, provocou a
indignação coletiva e trouxe um resultado eleitoral de rechaço às forças políticas dominantes em cada país: no Equador, o veto ao correísmo veio de dentro do sistema partidário e pela via
da direita neoliberal junto à falta de maior apoio dos movimentos populares, enquanto no
Peru o veto ao fujimorismo rompeu o quadro partidário existente por meio de um marxismo
improvisado.
KIAA1429/VIRMA promotes breast cancer progression by m6A‐dependent cytosolic HAS2 stabilization
Authors: Li Na , Zhu Zhouting , Deng Yufei , Tang Rachel , Hui Hui , Kang Yuqi , Rana Tariq M 
Published: September 2023

AbstractN6‐methyladenosine (m6A), the most abundant internal modification in eukaryotic mRNA, plays important roles in many physiological and pathological processes, including the development and progression of cancer. RNA modification by m6A is regulated by methyltransferases, demethylases, and m6A‐binding proteins that function in large part by regulating mRNA expression and function. Here, we investigate the expression of m6A regulatory proteins in breast cancer. We find that expression of KIAA1429/VIRMA, a component of the m6A methyltransferase complex, is upregulated in breast cancer tissue and correlates positively with poor survival. KIAA1429/VIRMA is mislocalized to the cytosol of breast cancer tissues and cell lines, and shRNA‐mediated knockdown inhibits breast cancer cell proliferation, migration, and invasion. Mechanistically, KIAA1429/VIRMA is shown to bind to the m6A‐dependent RNA‐binding protein insulin‐like growth factor 2 mRNA‐binding protein 3 (IGF2BP3), leading to recruitment and stabilization of m6A‐modified hyaluronan synthase 2 (HAS2) mRNA. HAS2 mRNA and KIAA1429/VIRMA mRNA levels correlate positively in breast cancer tissues, suggesting that the KIAA1429/VIRMA–IGF2BP3–HAS2 axis promotes breast cancer growth and contributes to poor prognosis.
Inventaritation and Potential Utilization of Macroscopic Mushroom in TPKh Tenjo KPH Bogor
Authors: Alfatinnisa Zalfa , Mahardhika Wahyu Aji , Lunggani Arina Tri , Putra Ivan Permana 
Published: September 2023

The TPKh Tenjo KPH Bogor is a production forest wood collection area and becomes a production forest for the Acacia mangium wood species. Timber harvesting activities leave a lot of tree stumps, twigs, or piles of wood that do not pass production. Environmental conditions with a lot of harvested wood residue and supported by relatively cool air temperatures and high humidity, it is suspected this area has a diversity of macroscopic fungi with various unknown potentials. This study aims to obtain data on the types of macroscopic fungi and their potential uses. The research method includes the stages of exploration, identification and literature study to obtain the potential of the macroscopic fungi found. The research succeeded in finding 8 types of macroscopic fungi classified into the phylum Basidiomycota, 3 orders, 5 families, and 7 genera. The macroscopic fungi include Coprinellus sp., Lentinus sp., Panus sp., Schizophyllum commune, Pycnoporus sp., Fomitopsis sp. 1, Fomitopsis sp. 2, and Lycoperdon sp. Based on the results of the literature study, the potential uses of macroscopic fungi were found are as food, medicine, natural pigment producer, and enzyme producer. This data report can be used as basic information on the use of macroscopic mushrooms by communities around the area to be used as food or medicinal ingredients. Further utilization of this data is the development of the potential of macroscopic fungi that produce enzymes, pigments or drugs to be produced on a large scale. Research on the development of potential mushroom conservation strategies can also be carried out for sustainable use.