bluuebunny/crossref_metadata_2025_split huggingface dataset:
Metabolism‐related biomarkers, molecular classification, and immune infiltration in diabetic ulcers with validation
Authors: Ma Xiao‐Xuan , Zhang Ying , Jiang Jing‐Si , Ru Yi , Luo Ying , Luo Yue , Fei Xiao‐Ya , Song Jian‐Kun , Ma Xin , Li Bin , Tan Yi‐Mei , Kuai Le 
Published: May 2023

AbstractDiabetes mellitus (DM) can lead to diabetic ulcers (DUs), which are the most severe complications. Due to the need for more accurate patient classifications and diagnostic models, treatment and management strategies for DU patients still need improvement. The difficulty of diabetic wound healing is caused closely related to biological metabolism and immune chemotaxis reaction dysfunction. Therefore, the purpose of our study is to identify metabolic biomarkers in patients with DU and construct a molecular subtype‐specific prognostic model that is highly accurate and robust. RNA‐sequencing data for DU samples were obtained from the Gene Expression Omnibus (GEO) database. DU patients and normal individuals were compared regarding the expression of metabolism‐related genes (MRGs). Then, a novel diagnostic model based on MRGs was constructed with the random forest algorithm, and classification performance was evaluated utilizing receiver operating characteristic (ROC) analysis. The biological functions of MRGs‐based subtypes were investigated using consensus clustering analysis. A principal component analysis (PCA) was conducted to determine whether MRGs could distinguish between subtypes. We also examined the correlation between MRGs and immune infiltration. Lastly, qRT‐PCR was utilized to validate the expression of the hub MRGs with clinical validations and animal experimentations. Firstly, 8 metabolism‐related hub genes were obtained by random forest algorithm, which could distinguish the DUs from normal samples validated by the ROC curves. Secondly, DU samples could be consensus clustered into three molecular classifications by MRGs, verified by PCA analysis. Thirdly, associations between MRGs and immune infiltration were confirmed, with LYN and Type 1 helper cell significantly positively correlated; RHOH and TGF‐β family remarkably negatively correlated. Finally, clinical validations and animal experiments of DU skin tissue samples showed that the expressions of metabolic hub genes in the DU groups were considerably upregulated, including GLDC, GALNT6, RHOH, XDH, MMP12, KLK6, LYN, and CFB. The current study proposed an auxiliary MRGs‐based DUs model while proposing MRGs‐based molecular clustering and confirmed the association with immune infiltration, facilitating the diagnosis and management of DU patients and designing individualized treatment plans.
Long non‐coding RNA as a novel biomarker and therapeutic target in aggressive B‐cell non‐Hodgkin lymphoma: A systematic review
Authors: Khanmohammadi Shaghayegh , Fallahtafti Parisa 
Published: May 2023

AbstractCancer initiation and progression have been associated with dysregulated long non‐coding RNA (lncRNA) expression. However, the lncRNA expression profile in aggressive B‐cell non‐Hodgkin lymphoma (NHL) has not been comprehensively characterized. This systematic review aims to evaluate the role of lncRNAs as a biomarker to investigate their future potential in the diagnosis, real‐time measurement of response to therapy and prognosis in aggressive B‐cell NHL. We searched PubMed, Web of Science, Embase and Scopus databases using the keywords “long non‐coding RNA”, “Diffuse large B‐cell lymphoma”, “Burkitt's lymphoma” and “Mantle cell lymphoma”. We included studies on human subjects that measured the level of lncRNAs in samples from patients with aggressive B‐cell NHL. We screened 608 papers, and 51 papers were included. The most studied aggressive B‐cell NHL was diffuse large B‐cell lymphoma (DLBCL). At least 79 lncRNAs were involved in the pathogenesis of aggressive B‐cell NHL. Targeting lncRNAs could affect cell proliferation, viability, apoptosis, migration and invasion in aggressive B‐cell NHL cell lines. Dysregulation of lncRNAs had prognostic (e.g. overall survival) and diagnostic values in patients with DLBCL, Burkitt's lymphoma (BL), or mantle cell lymphoma (MCL). Furthermore, dysregulation of lncRNAs was associated with response to treatments, such as CHOP‐like chemotherapy regimens, in these patients. LncRNAs could be promising biomarkers for the diagnosis, prognosis and response to therapy in patients with aggressive B‐cell NHL. Additionally, lncRNAs could be potential therapeutic targets for patients with aggressive B‐cell NHL like DLBCL, MCL or BL.
Behavioral health integration in the Program of All‐Inclusive Care for the Elderly (PACE): A scoping review
Authors: Fleet Alexa , Shalev Daniel , Spaeth‐Rublee Brigitta , Patterson Taryn , Wardlow Liane , Simoun Alya , Tomy Meril , Pincus Harold Alan 
Published: May 2023

AbstractBackgroundThe Program of All‐inclusive Care for the Elderly (PACE) is a community‐based care model that delivers collaborative care via an interdisciplinary team to meet the medical and social needs of older adults eligible for nursing home placement. Fifty‐nine percent of PACE participants are reported to have at least one psychiatric disorder. PACE organizations (POs) function through an interdisciplinary model of care, but a behavioral health (BH) provider is not a mandated role on the interdisciplinary team. Published literature regarding how POs integrate and provide BH services is limited; however, the National PACE Association (NPA) and select POs have made significant contributions to behavioral health integration (BHI) efforts in PACE.MethodsPubMED, EMBASE, and PsycINFO were searched for articles published between January 2000 and June 2022; hand‐searching was also conducted. Research articles and items involving BH components or programming in POs were included. Evidence of BH programming and initiatives at the organization and national level was summarized.ResultsThis review reported on nine primary items addressing BH in POs from 2004 to 2022. It found evidence of successful BH initiatives in PACE and identified a gap of published information given an evident need for BH services in the PACE participant population. Findings also indicate the NPA works to advance BH integration in POs with a dedicated workgroup that has produced the NPA BH Toolkit, BH training webinar series, and a site coaching program.ConclusionsIn the absence of PACE‐specific BH delivery guidelines and guidance from the federal or state level for PACE programs, BH service inclusion has been developed unevenly across POs. Assessing the landscape of BH inclusion across POs is a step toward evidence‐based and standardized inclusion of BH within the all‐inclusive care model.
Caspr1 antibodies autoimmune paranodopathy with severe tetraparesis: Potential relevance of antibody titers in monitoring treatment response
Authors: Bresciani Lorenzo , Salvalaggio Alessandro , Vegezzi Elisa , Visentin Andrea , Fortuna Andrea , Anglani Mariagiulia , Cacciavillani Mario , Masciocchi Stefano , Scaranzin Silvia , Carecchio Miryam , Martinuzzi Andrea , Gastaldi Matteo , Briani Chiara 
Published: May 2023

AbstractAimNodopathies and paranodopathies are autoimmune neuropathies associated with antibodies to nodal–paranodal antigens (neurofascin 140/186 and 155, contactin‐1, contactin‐associated protein 1 [Caspr1]) characterized by peculiar clinical features, poor response to standard immunotherapies (e.g., intravenous immunoglobulins, IVIg). Improvement after anti‐CD20 monoclonal antibody therapy has been reported. Data on Caspr1 antibodies pathogenicity are still preliminary, and longitudinal titers have been poorly described.MethodsWe report on a young woman who developed a disabling neuropathy with antibodies to the Caspr1/contactin‐1 complex showing a dramatic improvement after rituximab therapy, mirrored by the decrease of antibody titers.ResultsA 26‐year‐old woman presented with ataxic‐stepping gait, severe motor weakness at four limbs, and low frequency postural tremor. For neurophysiological evidence of demyelinating neuropathy, she was diagnosed with chronic inflammatory demyelinating polyradiculoneuropathy and treated with IVIg without benefit. MRI showed symmetrical hypertrophy and marked signal hyperintensity of brachial and lumbosacral plexi. Cerebrospinal fluid showed 710 mg/dL protein. Despite intravenous methylprednisolone, the patient progressively worsened, and became wheelchair‐bound. Antibodies to nodal–paranodal antigens were searched for by ELISA and cell‐based assay. Anticontactin/Caspr1 IgG4 antibodies resulted positive. The patient underwent rituximab therapy with slow progressive improvement that mirrored the antibodies titer, measured throughout the disease course.ConclusionsOur patient had a severe progressive course with early disability and axonal damage, and slow recovery starting only a few months after antibody‐depleting therapy. The close correlation between titer, disability, and treatment, supports the pathogenicity of Caspr1 antibodies, and suggest that their longitudinal evaluation might provide a potential biomarker to evaluate treatment response.
Incidence of and risk factors for local complications of peripheral venous catheters in patients older than 70 years: Empirical research quantitative
Authors: Gras Emmanuelle , Jean Alexia , Rocher Vincent , Tran Yohann , Katsahian Sandrine , Jouclas Diane , Dano Catherine , Cedile Johane , Manar Dalinda , Kassis Chikhani Najiby , Le Guen Julien , Patas D’illiers Clémence , Lebeaux David 
Published: May 2023

AbstractAimsTo assess the incidence density of local complications of peripheral venous catheters in patients aged 70 years and older, to identify risk factors for local complications of peripheral venous catheters, to describe microbiological epidemiology and to assess the impact of complications on patient outcomes.DesignProspective, observational, single‐centre study.MethodsPatients 70 years and older admitted to the geriatric department of a teaching hospital in France between December 2019 and May 2020 were considered for inclusion if they had a peripheral venous catheter during their stay. Nurses checked the catheter insertion site three times a day for local complications; physicians ensured the follow‐up of complications. The STROBE checklist was used in this prospective observational study.ResultsA total of 322 patients were included, with 849 peripheral venous catheters; the median age was 88 years and 182 (56.5%) were women. The incidence density of local complications was 50.5/1000 peripheral venous catheter‐days. Risk factors for local complications on multivariate analysis were dressing replacement (OR 1.18), furosemide (OR 1.11) and vancomycin (OR 1.60) infusion, urinary continence (OR 1.09) and hematoma at the catheter insertion site (OR 1.15). Thirteen cellulitis and three abscesses were diagnosed. Occurrence of a local complication was associated with a 3‐day increased duration of hospital stay (17 vs. 14 days).ConclusionRisk factors for peripheral venous catheter local complications include urinary continence, furosemide or vancomycin infusion, hematoma at the peripheral venous catheter insertion site or dressing replacement.Implication for the Patient CareCloser clinical monitoring may help reduce the occurrence of local peripheral venous catheters complication in patients 70 years and older.Relevance to Clinical PracticePatients at greater risk of peripheral venous catheter local complications deserve closer clinical monitoring or improved preventive measures, which may be beneficial to reduce the length of hospital stay.No Patient or Public ContributionThe study was designed to describe risk factors for local complications of peripheral venous catheters in order to reinforce surveillance in this specific population by nurses and medical staffs. Patients had their peripheral venous catheter insertion site checked thrice a day by the nurse in charge as part of usual care. They, as service users, caregivers or members of the public, were not solicited for data collection, analysis, interpretation or preparation of the manuscript.
Fifty years of development of neuroscientific insights into oro‐facial pain and its control
Authors: Sessle Barry J. 
Published: May 2023

AbstractWhen the Journal of Oral Rehabilitation was established in 1973, there was very limited understanding of the mechanisms underlying neurally based functions, including those unique to the face, mouth and jaws (e.g. dental pain, taste, chewing, swallowing and salivation). Since that time, technological and other advances have led to new insights into the structure, connectivity and function of cranial nerves and areas of the central nervous system (CNS) involved in oro‐facial functions and disorders or related functions (e.g. cognition, emotion, stress, consciousness, sleep, learning and memory). This review focuses on the advances in understanding of the neural basis of oro‐facial pain and its control over the past five decades. The review first briefly considers how oro‐facial pain conditions are now classified, diagnosed and managed. It then outlines novel insights that have been gained over this period through neuroscience research into the neural basis of these oro‐facial pain conditions and the clinical relevance to these insights to the diagnosis and management of these conditions. The review also identifies promising research directions and gaps in knowledge that still need to be addressed to improve the understanding, diagnosis and management of oro‐facial pain conditions.
Predicting oral cancer survival—Development and validation of an Asia‐Pacific nomogram
Authors: Wang Weilan , Zhang Qingpeng , Thomson Peter , Sharma Dileep , Ramamurthy Poornima , Choi Siu‐Wai 
Published: May 2023

AbstractBackgroundNomograms are graphical calculating devices that predict response to treatment during cancer management. Oral squamous cell carcinoma (OSCC) is a lethal and deforming disease of rising incidence and global significance. The aim of this study was to develop a nomogram to predict individualized OSCC survival using a population‐based dataset obtained from Queensland, Australia and externally validated using a cohort of OSCC patients treated in Hong Kong.MethodsClinico‐pathological data for newly diagnosed OSCC patients, including age, sex, tumour site and grading, were accessed retrospectively from the Queensland Cancer Registry (QCR) in Australia and the Clinical Data Analysis and Reporting System (CDARS) in Hong Kong. Multivariate Cox proportional hazard regression was used to construct overall survival (OS) and cancer‐specific survival (CSS) prediction models. Nomograms were internally validated using 10‐fold cross validation, and externally validated against the Hong Kong dataset.ResultsData from 9885 OSCC patients in Queensland and 465 patients from Hong Kong were analysed. All clinico‐pathological variables significantly influenced survival outcomes. Nomogram calibration curves demonstrated excellent agreement between predicted and actual probability for Queensland patients. External validation in the Hong Kong population demonstrated slightly poorer nomogram performance, but predictive power remained strong.ConclusionBased upon readily available data documenting patient demographic and clinico‐pathological variables, predictive nomograms offer pragmatic aid to clinicians in individualized treatment planning and prognosis assessment in contemporary OSCC management.
Dimensions of Identity Development Scale: Confirmatory factor analysis, gender invariance, and external validity of the Persian version
Authors: Salehi Yegaei Pardis , Achenbach Thomas M. , Trejos‐Castillo Elizabeth , Mastrotheodoros Stefanos , Izanloo Balal , Habibi Asgarabad Mojtaba 
Published: May 2023

AbstractThe present study was conducted to examine the psychometric properties and gender invariance of the Iranian version of the Dimensions of Identity Development Scale (DIDS). A total of 1453 adolescents (50.8% female; 14–18 years old, mean = 15.48) participated in a cross‐sectional study and completed the DIDS and the Youth Self‐Report of behavior problems. The Confirmatory Factor Analysis supported the six‐factor model of the DIDS, echoing past studies showing the original 5th factor (Exploration in Depth) being divided into Exploration in Depth and Reconsidering the Commitment. The invariance testing showed comparable measurement properties of the DIDS across males and females (strict measurement invariance). Further, behavior problems were associated positively with Ruminative Exploration and negatively with Commitment Making, Identification with Commitments, Exploration in Depth, and Reconsideration of Commitments, whereas the opposite was true for academic performance. A six‐factor DIDS was shown to be a valid and reliable measure for the assessment of identity development dimensions among Iranian adolescents. Future studies in the Iranian context evaluating the identity clusters derived from identity dimensions and their gender differences are warranted.
Loss of body weight and lean mass in long‐stay, hospitalized canine patients
Authors: Leung Y. Becca , Cave Nick , Wester Timothy J. 
Published: May 2023

AbstractA high prevalence of malnutrition occurs in human hospitals and has been associated with detrimental consequences. By comparison, much less is known in hospitalized veterinary patients. The aims of this study were to evaluate the prevalence of malnutrition and body composition changes in long‐stay hospitalised patients using an isotopic dilution technique. An additional objective was to compare the changes in composition with commonly used methods measuring body fat and lean mass. The dogs consumed on average 77.5% of their estimated resting energy requirements during their stay. The majority (78.3%) of dogs lost body weight, of which a greater proportion was lean mass (61.8%) than fat mass (FM) (38.2%). There was a moderate correlation between body condition score and percentage FM measured at admission (Kendall'sτ = 0.51;p = 0.002), and at discharge (Kendall'sτ = 0.55;p = 0.001). However, there was no correlation between muscle condition score and fat‐free mass at either admission or discharge (p > 0.1). Duration of stay was positively associated with loss of body weight (p < 0.001), but was not associated with changes in either lean or FM expressed as a percentage of body weight or in absolute terms (p > 0.1), which was presumed to be explained by small sample size and variation. Food intake was not found to a significant factor for lean or FM loss (p > 0.1). These findings indicate that weight loss is common in hospitalized canine patients, which is not explained by simple under‐eating. Other factors such as inflammation and inactivity should be evaluated in future studies to determine their role in influencing muscle and FM changes in hospitalized canine patients.
What Is Haydn Doing in a John Field Nocturne?
Authors: SUTCLIFFE W. DEAN 
Published: May 2023

ABSTRACTThe middle section of John Field's Nocturne No. 13 in D minor, published in 1834, towards the end of the composer's life, begins with what appears to be a quotation from the start of the finale of Haydn's Quartet in E♭ major Op. 76 No. 6. Apart from the transposition of Haydn's theme to D major and the use of a different medium, the respective passages are all but identical. This unlikely correspondence is all but unknown and has never been critically discussed. I show that the quotation is no isolated event; indeed, it turns out to be integral to Field's conception of the entire nocturne. The first section, at least in retrospect, can be heard to work with the same shapes, though in the minor mode, before they are transformed by their major‐mode guise in the followingpiù motosection. I consider the affective implications of the quotation in the context of the whole work as well as its possible significance for Field himself and his milieu. Beyond those considerations, the quotation is significant for what it tells us about the reception of Haydn in a supposedly hostile or indifferent nineteenth century.
A false dichotomy in denying explanatoriness any role in confirmation
Authors: Lange Marc 
Published: May 2023

AbstractRoche and Sober (2013; 2014; 2017; 2019) have offered an important new argument that explanatoriness lacks confirmatory significance. My aim in this paper is not only to contend that their argument fails to show that in confirmation ‘there is nothing special about explanatoriness’ (Roche & Sober, 2017: 589), but also to reveal what is special confirmationwise about explanatoriness. I will argue that much of the heavy work in Roche and Sober's argument is done by the dichotomy into which they carve up the philosophical options: either explanatory considerations per se are confirmatorily relevant or they acquire whatever confirmatory significance they may possess only by way of background beliefs and so no differently from non‐explanatory considerations. I will argue that this is a false dichotomy: Explanatoriness per se can have confirmatory relevance even while explanatory considerations acquire their confirmatory relevance only through background opinions. Furthermore, there is ‘something special’ about the background opinions concerning explanations that allow explanatoriness in itself to have confirmatory impact. Unlike other sorts of background, having some background opinions expressly about explanations is indispensable to being an observer at all.
3D analysis of maxillomandibular morphology in hyperdivergent and hypodivergent individuals: A cross‐sectional study
Authors: Reis Alyson de Souza , Copello Flavio de Mendonca , de Castro Amanda Cunha Regal , Cevidanes Lucia Helena Soares , do Rego Marcus Vinicius , Visconti Maria Augusta , Ruellas Antônio Carlos de Oliveira 
Published: May 2023

AbstractIntroductionThe aim of this cross‐sectional study was to investigate maxillomandibular morphology in hyperdivergent and hypodivergent individuals, using 3D surface models generated by cone‐beam computed tomography (CBCT).MethodsThe sample consisted of 60 CBCTs (30 males, 30 females) patients aged 12–30 years, divided into two groups comprising hyperdivergent (≥35°) and hypodivergent (≤30°) individuals, according to the mandibular plane (MP) angle. Multiplanar reconstructions were used to mark the landmarks, and 3D surface models were created to evaluate structures of the maxillomandibular complex, including condyle, ramus, symphysis and palatal height. Intergroup comparisons were performed by independent t‐test. Pearson's correlation test was used (P < .05) to evaluate the correlation of the MP angle with the angles and linear measurements of other structures.ResultsSignificant differences were found between the groups regarding condylar width, ramus height, condylar plus ramus height, mandibular length, gonial angle, palatal plane angle and palatal‐mandibular angle. No differences (P > .05) were found for the condylar height, symphysis inclination angle or palatal height. Correlations (P < .05) were found between the MP angle and structures of the maxillomandibular complex.ConclusionsHyperdivergent (MP ≥ 35°) and hypodivergent (MP ≤ 30°) individuals present different skeletal morphology regarding condylar width, ramus height, condylar plus ramus height, mandibular length, gonial angle, palatal plane angle and palatal‐mandibular angle. There is a significant correlation between MP angle and morphological structures such as condyle, ramus, symphysis, palatal plane angle and palatal‐mandibular angle.