bluuebunny/crossref_metadata_2025_split huggingface dataset:
Curcumin Regulates Microglia Polarization to Alleviate Ischemic Stroke by Targeting microRNA‐205‐5p/Kruppel‐Like Factor 2 (KLF2)/Activating Transcription Factor 2 (ATF2) Axis
Authors: Cao Xiangyu , Pu Yingzi 
Published: January 2025

ABSTRACTIschemic stroke (IS) often causes fearful sequela, even death. Curcumin was beneficial to IS, but its underlying molecular mechanism is unclear. Mice were subjected to middle cerebral artery occlusion (MCAO) surgery, and BV‐2 cells were treated with oxygen–glucose deprivation/reoxygenation (OGD/R) induction to establish IS models in vivo and in vitro. Abundance of genes and proteins was determined using quantitative real‐time polymerase chain reaction (RT‐qPCR), immunofluorescence (IF), and western blot. Interleukin‐1β (IL‐1β), interleukin‐6 (IL‐6), and interleukin‐10 (IL‐10) levels were analyzed using enzyme‐linked immunosorbent assay (ELISA). Modified neurological severity score (mNSS), corner test, foot fault test, adhesive removal test, and 2,3,5‐triphenyltetrazolium chloride (TTC) staining were applied to evaluate the brain injury of mice. The correlation between miR‐205‐5p and Kruppel‐like factor 2 (KLF2) was affirmed using dual luciferase reporter assay. Our results revealed that curcumin alleviated brain damage in MCAO mice through driving microglia M2 polarization. Of note, curcumin resulted in decreased miR‐205‐5p expression in MCAO mice. miR‐205‐5p knockdown resulted in promoted microglia M2 polarization in OGD/R conditions and achieved similar results to curcumin treatment in MCAO mice. Moreover, curcumin played a promoting role in microglia M2 polarization under OGD/R conditions, while miR‐205‐5p overexpression or KLF2 knockdown abolished these effects. On the mechanism, miR‐205‐5p was a target of curcumin, and miR‐205‐5p further interacted with KLF2 to inhibit activating transcription factor 2 (ATF2) expression. miR‐205‐5p, decreased by curcumin, suppressed microglia M2 polarization to worsen IS injury through the mediating KLF2/ATF2 axis.
The parent–child relationship and child shame and guilt: A meta‐analytic systematic review
Authors: van Eickels Rahel L. , Siegel Magdalena , Juhasz Alice J. , Zemp Martina 
Published: January 2025

AbstractEmpirical findings on the associations of positive and dysfunctional parent–child relationship (PPCR/DPCR) characteristics with child shame, adaptive guilt, and maladaptive guilt were synthesized in six meta‐analyses. The 65 included samples yielded 633 effect sizes (Ntotal = 19,144; Mage = 15.24 years; 59.0% female; 67.7% U.S. samples, n = 12,036 with 65% White, 12.3% Hispanic and Latinx, 10.8% Black, 6.3% mixed race, 5.6% Asian American, 0.3% Native American participants). Small positive correlations were found between DPCR and shame (r = .17), DPCR and maladaptive guilt (r = .15), and PPCR and adaptive guilt (r = .14). A small negative correlation was found between PPCR and shame (r = −.12). Sample and study moderators and sources of bias are investigated and discussed.
Natural and Artificial Structures Influence the Movement and Habitat Connectivity of Whale Sharks (Rhincodon typus) Across Seascapes
Authors: D'Antonio Ben , Ferreira Luciana C. , Fisher Rebecca , Thums Michele , Pattiaratchi Charitha B. , Sequeira Ana M. M. , Faubel Cal , Reynolds Samantha , Norman Brad , Meekan Mark 
Published: January 2025

ABSTRACTAimTo understand how natural geomorphological features and oil and gas platforms (OG platforms) influence the habitat use and seascape connectivity of the whale shark (Rhincodon typus).LocationEast‐Indian Ocean and North‐West Australia.MethodsWe compiled a satellite tracking dataset of 78 whale sharks tagged across a 14‐year period at Ningaloo Reef and Shark Bay World Heritage Areas in Western Australia to develop spatial networks for the regions of the East‐Indian Ocean and North‐West Australia. We then applied a Bayesian modelling framework to assess the effects of natural features and OG platforms on spatial patterns and habitat connectivity.ResultsGeomorphological features such as pinnacles, canyons, and seamounts promoted habitat connectivity and strongly influenced the habitat use of whale sharks across both regional (1000's km; East‐Indian Ocean) and local (100's km; North‐West Australia) spatial scales. In the North‐West of Australia, OG platforms had similar effects on habitat use as natural feature types and also enhanced habitat connectivity. The OG platforms most visited by whale sharks were situated close to the edge of the continental shelf and near natural geomorphological features that likely enhance productivity.Main ConclusionOur work identified natural geomorphological features that promoted habitat use and connectivity for whale sharks across oceanic and coastal seascapes. Sharks routinely visited OG platforms, which acted as migratory stepping stones that further enhanced habitat connectivity. Protection of natural feature types that promote habitat use and connectivity could assist conservation management of whale sharks. We suggest that the influence of OG platforms on their movement and habitat use beyond individual structures, should be considered in environmental impact assessments during operation and decommissioning phases.
Reconciling Variability in Multiple Stressor Effects Using Environmental Performance Curves
Authors: Carmichael Hebe , Warfield Ruth , Yvon‐Durocher Gabriel 
Published: January 2025

ABSTRACTUnderstanding the effects of multiple stressors has become a major focus in ecology and evolution. While many studies have investigated the combined effects of stressors, revealing massive variability, a mechanistic understanding that reconciles the diversity of multiple stressor outcomes is lacking. Here, we show how performance curves can fill this gap by revealing mechanisms that shape multiple stressor outcomes. Our experiments with 12 bacterial taxa, demonstrate that additional stressors alter the shape of temperature, pH and salinity performance curves. This leads to changes in stressor interaction outcomes—for example, shifts between additive, antagonistic or synergistic interactions—along gradients, revealing that small changes in a stressor along nonlinear performance curves can dramatically impact the stressor interaction. These findings help to explain the lack of generality found across multiple stressor studies and highlight how a performance curve approach can provide a more holistic view of multiple stressor interactions.
New onset refractory status epilepticus: Long‐term outcomes beyond seizures
Authors: Espino Poul H. , Eschbach Krista , Blank Leah J. , Cervenka Mackenzie C. , Muscal Eyal , Farias‐Moeller Raquel , Gilmore Emily J. , Gopaul Margaret T. , Haider Hiba A. , Hanin Aurelie , Hirsch Lawrence J. , Kellogg Marissa A. , Kluger Gerhard , Lee Soon‐Tae , Melendez‐Zaidi Alexandria E. , Navarro Vincent , Oliger Audrey C. , Pasini Elena , Reuner Gitta , Sharpe Cynthia M. , Sheikh Zubeda B. , Steigleder Leon , Steriade Claude , Stredny Coral M. , Strzelczyk Adam , Taraschenko Olga , van Baalen Andreas , Vinette Sarah A. , Wickström Ronny , Wong Nora W. , Yoo Jiyeoun , Gofton Teneille E. 
Published: January 2025

AbstractWe propose and prioritize important outcome domains that should be considered for future research investigating long‐term outcomes (LTO) after new onset refractory status epilepticus (NORSE). The study was led by the international NORSE Institute LTO Working Group. First, literature describing the LTO of NORSE survivors was identified using a PubMed search and summarized to identify knowledge gaps. Subsequently, a consensus‐building process was performed to prioritize and rank important LTO domains for further research. The prioritization of LTO domains was qualitative, enabling the expert panel to generate ideas, share opinions, and provide reasons for the rankings. A second round took place to allow expansion and agreement regarding specific details for each domain. Outcomes were classified into eight main domains: (1) Function: Neuropsychological, Neurological (other than seizures), and Psychiatric (mood and behavior); (2) Quality of Life; (3) Epilepsy; (4) Nonneurological (medical); (5) Social; (6) Caregiver Burden; (7) Long‐Term Mortality; and (8) Health Care System Impact. In addition, the working group suggested obtaining outcome measures for each domain at 6 months and 1 year after discharge and annually thereafter until stability has been reached. There are no currently established time frames set for when LTO in NORSE begin or plateau, and previously there existed no consensus regarding which LTO should be considered. This consensus process identifies and recommends NORSE LTO domains that should be considered in future research studies to provide more consistent results that can be compared between studies. Survivors of NORSE should be evaluated serially and at fixed points over time to maximize our understanding of the recovery trajectory for all LTO domains. Establishing reliable and standardized data describing LTO (beyond seizures) after NORSE will support discussions with families during the acute stages, prognostication, the development of targeted management strategies for survivors, and future comparative research globally helping to identify biomarkers that may predict LTO.
Risk scoring system for evaluating pathological upstaging after radical nephroureterectomy for upper tract urothelial carcinoma: A multicenter study in Japan
Authors: Yamane Hiroshi , Morizane Shuichi , Yamaguchi Noriya , Toji Sumiyo , Hikita Katsuya , Honda Masashi , Muraoka Kuniyasu , Oono Hirofumi , Isoyama Tadahiro , Ono Koji , Sejima Takehiro , Takenaka Atsushi 
Published: January 2025

ObjectivesAccurate preoperative staging of upper tract urothelial carcinoma is often difficult. Therefore, we aimed to investigate the preoperative factors associated with pathological upstaging in patients with upper tract urothelial carcinoma undergoing radical nephroureterectomy and to develop a risk‐scoring system to assess pathological upstaging.MethodsThis retrospective study enrolled 386 patients with upper tract urothelial carcinoma who underwent radical nephroureterectomy at Tottori University Hospital and affiliated hospitals between January 2015 and December 2021. Patients with clinical tumor stage 4, clinical node +, and those who received neoadjuvant chemotherapy were excluded from the study. The association between preoperative patient factors and pathological upstaging was analyzed. Statistical analyses included the t‐test, chi‐squared test, and logistic regression analysis.ResultsOf the 386 patients, 32 were excluded. Finally, 354 patients were included in this study, of whom 87 (24.6%) were pathologically upstaged. Hydronephrosis, positive urine cytology result, and maximum tumor diameter <30 mm were associated with upstaging. We developed a risk scoring system in which the score was the sum of the number of applicable items for three factors: hydronephrosis, positive urine cytology result, and maximum tumor size <30 mm. The probabilities of ureteral cancer upstaging were 0%, 8.3%, 29.5%, and 50.0% for scores of 0, 1, 2, and 3, respectively.ConclusionsHydronephrosis, urine cytology, and maximum tumor diameter were associated with pathological upstaging. Our risk‐scoring system may be useful in predicting pathological upstaging, especially in patients with ureteral cancer.
Cultural Differences in Visual Attention Emerge in Infancy
Authors: Heise Megan J. , Meristo Marek , Ueno Mika , Itakura Shoji , Carlson Stephanie M. 
Published: January 2025

ABSTRACTEast Asians are more likely than North Americans to attend to visual scenes holistically, focusing on the relations between objects and their background rather than isolating components. This cultural difference in context sensitivity—greater attentional allocation to the background of an image or scene—has been attributed to socialization, yet it is unknown how early in development it appears, and whether it is moderated by social information. We employed eye‐tracking to investigate context‐sensitivity in 15‐month‐olds in Japan (n = 45) and the United States (n = 52). Viewing faces, Japanese infants were more attentive and studied the background longer than U.S. infants. Viewing cartoon videos, Japanese infants looked at the background twice as long as U.S. infants, particularly for objects with eyes. In parent‐child book reading, Japanese parents referred to the background significantly more than U.S. parents, although this was uncorrelated with infant behavior on the preceding tasks. These findings illustrated that cultural differences in attention are detectable in infancy, and that sustained attention may be an important foundation upon which culturally‐specific attentional styles are built. Overall, results were consistent with the view that a context‐sensitive orientation first emerges for social information and later generalizes to non‐social situations.
Evaluating a Virtual Community‐of‐Practice as Implementation Strategy for the Needs Assessment Framework in Intellectual Disability Care: A Quasi‐Experimental Multi‐Methods Study
Authors: Bisschops Esther H. , Frielink Noud , de Schipper J. Clasien , Schuengel Carlo , Embregts Petri J. C. M. 
Published: January 2025

ABSTRACTBackgroundThe Needs Assessment Framework (NAF) stimulates awareness of care staff to consider perspectives of clients with intellectual disabilities in decisions on involuntary care. We explored the effect of implementers' participation in a Virtual Community‐of‐Practice (VCoP) for designing implementation plans, on NAF implementation and staff awareness.MethodA quasi‐experimental design was used to compare implementation and awareness by care staff (n = 54) between organisations that implemented NAF with VCoP participation (N = 4) and organisations that implemented NAF as usual (N = 3). The ItFits toolkit work routine in the VCoP was qualitatively analysed to understand choices regarding implementation plans.ResultsNo statistical differences in implementation and awareness among care staff were found between the intervention and control groups. Implementers evaluated collaboration on implementation and the ItFits toolkit as helpful.ConclusionsEvaluation of implementation effectiveness and process are both needed to offer unique insights for iteratively changing daily practice around involuntary care.
Sacubitril/Valsartan for Blood Pressure Lowering in Non‐Dialysis‐Dependent Chronic Kidney Disease Stage 3–5 Patients With Hypertension: A Multicenter Clinical Study
Authors: Yan Yu , Li Xiaomin , Cao Juan , Cao Jingyuan , Wang Yao , Wang Liang , Yu Jirong , Chen Lianhua , Yang Min , Huang Xinzhong , Shen Lei , Ding Hong , Li Manzhi , Yin Di , Jiang Linglin , Tang Liang , Jiang Yujia , Hu Ling , Si Jiyi , Zhang Hui , Cui Liqin , Gu Xiameng , Hu Kun , Mu Dongxing , Liu Bicheng , Zhang Xiaoliang , Sun Dong , Wan Xin , Wang Bin 
Published: January 2025

ABSTRACTTo assess the effectiveness and safety of Sacubitril/Valsartan in reducing blood pressure in individuals with non‐dialysis‐dependent chronic kidney disease (NDD‐CKD) Stage 3–5 complicated by hypertension. This study was a multicenter retrospective analysis conducted from March 1, 2022 to March 31, 2024, involving adult patients with NDD‐CKD Stage 3–5 and hypertension, who received Sacubitril/Valsartan either as a monotherapy or in addition to current antihypertensive treatments that were insufficient. The main outcomes measured were blood pressure control, changes in blood pressure and laboratory parameters within 8 weeks post‐treatment initiation, and incidence of adverse events. The study included a total of 459 individuals with NDD‐CKD Stage 3–5 and hypertension. At the study endpoint, mean systolic blood pressure, diastolic blood pressure, and pulse pressure were markedly reduced compared to baseline (all p < 0.001). The average blood pressure reductions were 12.17 (4.66, 22.00), 6.00 (0.67, 12.66), and 6.67 (0.08, 14.00) mmHg, respectively. Throughout the study period, 96 patients (20.92%) with NDD‐CKD Stage 3–5 developed worsening renal function, 15 patients (3.27%) developed hyperkalemia, and 49 patients (10.68%) experienced symptomatic hypotension. Overall, there were no significant differences in the changes in serum creatinine, estimated glomerular filtration rate, and serum potassium before and after treatment (p = 0.28, p = 0.91, p = 0.61, respectively). Sacubitril/Valsartan significantly lowers blood pressure in patients with NDD‐CKD Stage 3–5 complicated by hypertension, with good safety profiles.Trial Registration: ClinicalTrials.gov identifier: ChiCTR2400086079
The optimal group size of deliberative mini‐publics: A divide in perceptions
Authors: Waterschoot Milena , Haesevoets Tessa , Roets Arne 
Published: January 2025

AbstractDeliberative mini‐publics (DMPs) have the potential to bolster political trust, although poorly organized ones may worsen existing distrust. Therefore, it is essential to consider citizens' perceptions regarding their implementation. This article examines a key aspect in this regard: the optimal group size of DMPs, as perceived by the public. Three studies were conducted: an exploratory pilot study (n = 194 Belgian citizens), Study 1 (n = 516 UK citizens), and Study 2 (n = 527 UK citizens), which was a preregistered replication in a representative sample. In each study, participants evaluated various DMP sizes on four dimensions of legitimacy: representativeness, deliberation quality, efficiency, and efficacy. Our findings indicate that most participants intuitively make a trade‐off between these different dimensions when evaluating how many citizens should partake in DMPs. In particular, a group of 100 citizens was identified as the size for DMPs to be perceived as representative, without compromising the perceived deliberation quality, efficiency, and efficacy. Remarkably, however, there is also a distinct and substantial group of participants who demand more than 1000 participating citizens to be satisfied. Implications and directions for future research are discussed.
An Adaptive Spatial-Terminal Iterative Learning Strategy in Roll-to-Roll Control Problems
Authors: Wang Zifeng , Jin Xiaoning 
Published: January 2025

Abstract
Roll-to-Roll (R2R) systems, featuring motorized or idle rollers, are crucial for high-volume, continuous production of flexible substrates. A significant challenge in R2R printing processes is maintaining tight alignment tolerances for multilayer printed electronics. This alignment, known as registration, is complicated by the deformability of flexible substrates and complex roller dynamics, leading to registration errors (RE) caused by variations in substrate tensions and speeds. Despite using real-time feedback controllers like proportional-integral-derivative (PID) or model predictive control for tension control, these systems struggle with transient and angle-periodic disturbances common in R2R systems. We introduce a spatial-terminal iterative learning control (STILC) method with an adaptive basis function to eliminate RE in R2R gravure printing. This function, along with the registration error, updates the STILC compensation profile via a P-type iterative learning control (ILC) law. Our numerical experiments demonstrate that STILC with the adaptive basis function effectively eliminates RE caused by roller-motor axis mismatches and provides better convergence than STILC with an invariant basis function. This novel approach shows promise for various industrial applications involving spatially periodic disturbances, particularly those with unknown dynamics and without given state trajectories to track rigorously, which is common in engineering practice.
Optimization of Micropillars Electroplating Bonding Processes and Additives
Authors: Zhang Qiang , Chen Changping , Yang Haoze , Zhang Jiameng , Xiao Mengtao , Dou Long , Li Junhui 
Published: January 2025

Abstract
With the increasing interconnect density of electronic components, copper–copper direct bonding technology has garnered increasing attention from researchers. The electroplating bonding method is an efficient copper pillar interconnection technique that can be implemented at room temperature and atmospheric pressure. comsol simulation results show that under convective conditions, the plating layer primarily deposits on the convection exit side of the copper plate. Under weak convection and low current density, the plating exhibits deposition characteristics that conform to the substrate surface. As convection intensity increases, preferential deposition begins to occur, although the overall deposition rate decreases. At this point, when the current density is increased, the deposition pattern predominantly shows preferential deposition; however, excessively high current density can lead to copper deposition in nonbonding areas. Orthogonal experimental results indicate that, within the accelerator bis(3-sulfopropyl) disulfide (SPS)–inhibitor polyethylene glycol (PEG)–leveling agent Jenner Green B (JGB)–chloride ion (Cl−) system, the influence of the four additives on bonding strength follows this order: JGB &gt; Cl− &gt; SPS &gt; PEG. The optimal formulation derived from the orthogonal experiments is SPS 2 ppm, PEG (8000) 150 ppm, JGB 5 ppm, and Cl− 30 ppm, which results in a shear strength of 123.2 MPa. These findings suggest that high-strength copper pillar interconnections can be achieved by adjusting physical parameters such as the electric field, flow field, and additive concentrations.
Return to Sport After Partum in Patients With Diastasis of the Rectus Abdominis Muscles: Ultrasound Evaluation and Rehabilitation Protocol
Authors: Vita Fabio , Donati Danilo , Amouso Vincenza , Stella Salvatore Massimo , Fantini Marta , Tedeschi Roberto , Miceli Marco , Galletti Stefano , Faldini Cesare 
Published: January 2025

Background: Diastasis rectus abdominis is a condition in which the rectus abdominis muscles separate and move laterally, causing stretching of the linea alba tissue with weakness of the abdominal wall. Although it can lead to hernia of the abdominal viscera, diastasis rectus abdominis is not a hernia in itself. This condition is common among women during pregnancy and the postpartum period and can significantly affect their quality of life and their return to sports activity. Unfortunately, information on the incidence, risk factors, prevention, and treatment of diastasis rectus abdominis are limited. Methods: We conducted a pilot prospective observational study on 37 patients who practiced sports at high levels (at least 3 times a week with amateur/competitive competitions) who underwent ultrasound measurements of the distance between the rectus abdominis muscles at the level of the xiphoid process, supraumbilical, umbilical, and subumbilical at time (T0), after 2 months from the rehabilitation protocol (T1), and then after 4 months of rehabilitation protocol (T2) from approximately 3 months after giving birth, and we saw an early return to sport. Results: Our data analysis reveals that there is an initial decrease in diastasis during the first 2 months with 3 weekly physiotherapy activity sessions in all 4 measurements. One session takes place on site with physiotherapists, while the other 2 are carried out at home using the rehabilitation protocol provided by the medical staff. At the 4-month follow-up, the improvement was similar to the previous follow-up. Conclusion: Of the 37 women analyzed, 6 were referred to the surgeon; 2 for hernias and 4 for diastases greater than 4 cm. The remaining women benefited from a conservative approach. Patients undergoing the rehabilitation protocol showed improvements in all 4 measures, as well as their early return to sport.