bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of Allergen‐Specific and Non‐Specific AGEs on the Allergenicity of Ovalbumin in a Mouse Model of Food Allergy
Authors: Yu Gang , Zhang Qiaozhi , Li Huatao , Wang Yanbo , Sheng Huadong , Zhang Shuifeng , Fu Linglin 
Published: December 2022

ScopeEpidemiologic studies suggest a link between the incidence of food allergy and the consumption of dietary advanced glycation end‐products (AGEs). However, the pathogenic role of dietary AGEs in food allergy is largely unknown. This study aims to investigate the effect of allergen‐specific and non‐specific AGEs on the allergenic manifestation of ovalbumin (OVA), a typical food allergen in vivo.Methods and resultsOVA is glycated by methylglyoxal to prepare allergen‐specific AGEs (i.e., OVA‐AGE), and a standard AIN‐93G diet is heated to obtain allergen‐non‐specific AGEs. A BALB/c mouse model orally sensitizes to OVA with different forms of AGEs is established and the outcomes are measured as clinical signs, specific antibodies, type‐2/type‐2 cytokines, immune cell subpopulations, intestinal barrier function, and gut microbiota (GM) composition. The OVA‐AGE which has a lower immunoglobulin E (IgE)‐binding level in vitro does not reduce the allergenicity of OVA but promotes a stronger T helper 2 cells (Th2)‐response than native OVA in vivo. Both forms of AGEs up‐regulate the expression of splenic RAGE and aggravate the destruction of gut barrier and GM dysbiosis, especially when exposes to non‐relevant AGEs.ConclusionThis study highlights the role of dietary AGEs in food allergy and helps to understand the biological consequences of immune‐toxic compounds in modern diet.
Registration of Arkot 0902 cotton germplasm line
Authors: Bourland Fred M. , Chee Peng W. , Jones Don C. 
Published: December 2022

AbstractArkot 0902 (Reg. no. GP‐1130, PI 700940) is a conventional cotton (Gossypium hirsutum L.) germplasm line released by the Arkansas Agricultural Experiment Station in May 2022. Arkot 0902 was derived from a cross of ‘GA 230’ (PVP 201500309) and Arkot 0012. Over 5 yr and four test sites in Arkansas, Arkot 0902 produced 10 and 20% higher lint yields than ‘UA222’ and ‘UA48’, respectively. The high lint yield of Arkot 0902 was attributed to producing more (and smaller) seed per area than UA222 or UA48. Arkot 0902 possesses leaf and stem pubescence similar to UA48 (smooth leaf) but has higher density of marginal bract trichomes. Arkot 0902 displayed high resistance to bacterial blight and was similar to UA222 and UA48 in their response to other diseases. Arkot 0902 was more resistant to tarnished plant bug than UA48 and equal to UA222. Most fiber quality traits of Arkot 0902 approached those of UA48, a high fiber–quality cultivar.
Calcium carbonate‐modified plant sporopollen capsule as an eco‐friendly microvehicle for controlled release of pesticide
Authors: Xiang Sheng , Kang Huajun , Chai Ali , Shi Yanxia , Xie Xuewen , Li Lei , Fan Tengfei , Li Baoju 
Published: December 2022

AbstractBackgroundIn this work, natural club moss (Lycopodium clavatum, LC) spores with a porous surface morphology and highly uniform size distribution were engineered into controlled‐release microvehicles for pesticide delivery. As a proof of concept, a widely used fungicide, fluazinam (FLU), was successfully loaded into LC spores and then modified with different amounts of CaCO3 (CaC) to extend the efficacy duration of FLU. Significantly, as the control target of FLU, clubroot disease is a worldwide destructive disease of cruciferous crops, and its development is favored by acidic soils and can be suppressed at high Ca concentrations.ResultsFabricated FLU@LC‐CaC microcapsules, FLU loading and CaCO3 deposition were systematically characterized by field emission scanning electron microscopy, Fourier transform infrared spectroscopy, and thermogravimetric analysis. The as‐prepared FLU@LC‐CaC microcapsules showed sustained‐release behaviors and were potentially able to supplement the Ca concentration in acidic environments. This approach synergistically enhanced in vivo bioactivity for the on‐demand control of clubroot disease. An in vivo bioassay revealed that the control efficacy of FLU@LC‐CaC against clubroot disease in pak choi (Brassica chinensis) (66.4%) was 1.7‐fold higher than that of a commercial FLU suspension concentrate (38.2%) over the course of the cultivation period (35 days).ConclusionsThis work provides new ideas not only for developing eco‐friendly and scalable microvehicles for pesticide delivery based on natural sporopollen, but also for unconventional research perspectives in on‐demand pest management based on their occurrence characteristics. © 2022 Society of Chemical Industry.
Selection for, and characterization of, malathion and zeta‐cypermethrin resistance in vineyard‐collected Drosophila melanogaster
Authors: Mertz Robert W. , DeLorenzo Samuel , Sun Haina , Loeb Gregory , Scott Jeffrey G. 
Published: December 2022

AbstractBACKGROUNDDrosophila melanogaster is a pest in vineyards because of its role in sour rot disease. Insecticides are commonly used, particularly late in the season, to control D. melanogaster and thus sour rot. Use of insecticides in vineyards and neighboring fruit production systems has led to the evolution of insecticide resistance in D. melanogaster, which is now widespread to commonly used insecticides like zeta‐cypermethrin and malathion. Implementation of resistance management strategies is facilitated by an understanding of the mechanisms and genetics underlying the resistance.RESULTSStarting with a vineyard‐collected strain of D. melanogaster (NY18), we selected for a strain that was 1100‐fold resistant to zeta‐cypermethrin and one that was 40‐fold resistant to malathion. Resistance was inherited as an incompletely dominant trait for zeta‐cypermethrin. Resistance to malathion was inherited differently between reciprocal crosses. Insecticide bioassays using insecticide synergists found resistance to zeta‐cypermethrin was partly suppressible with either piperonyl butoxide or S,S,S‐tributylphosphorotrithionate, while resistance to malathion was unchanged by the synergists and mutations in Ace associated with the resistance were found.CONCLUSIONSResistance to zeta‐cypermethrin is most likely due to enhanced detoxification, while the results with malathion were associated with two Ace alleles. How the newly selected strains can facilitate diagnostic tools for the identification of the mutations causing the resistance is discussed. © 2022 Society of Chemical Industry.
Molecular diagnostics for monitoring insecticide resistance in the western flower thrips Frankliniella occidentalis
Authors: Mavridis Konstantinos , Ilias Aris , Papapostolou Kyriaki Maria , Varikou Kyriaki , Michaelidou Kleita , Tsagkarakou Anastasia , Vontas John 
Published: December 2022

AbstractBACKGROUNDInsecticide resistance has emerged in various western flower thrips (WFT) populations across the world, threatening the efficiency of chemical control applications. Elucidation of insecticide resistance mechanisms at the molecular level provides markers for the development of diagnostics to monitor the trait and support evidence‐based resistance management.RESULTSTaqMan and Droplet Digital polymerase chain reaction (ddPCR) diagnostics were developed and validated, against Sanger sequencing, in individual and pooled WFT samples respectively, for the G275E mutation (nicotinic acetylcholine receptor α6 gene, nAChR α6) associated with resistance to nAChR allosteric modulators, site I (spinosyns); L1014F, T929I, T929C and T292V mutations (voltage‐gated sodium channel gene, vgsc) linked with pyrethroid resistance; and I1017M (chitin synthase 1 gene, chs1) conferring resistance to growth inhibitors affecting CHS1 (benzoylureas). The detection limits of ddPCR assays for mutant allelic frequencies (MAF) were in the range of 0.1%–0.2%. The assays were applied in nine WFT field populations from Crete, Greece. The G275E (MAF = 29.66%–100.0%), T929I and T929V (combined MAF = 100%), L1014F (MAF = 11.01%–37.29%), and I1017M (MAF = 17.74%–51.07%) mutations were present in all populations.CONCLUSIONThe molecular diagnostics panel that was developed in this study can facilitate the quick and sensitive resistance monitoring of WFT populations at the molecular level, to support evidence‐based insecticide resistance management strategies. © 2022 Society of Chemical Industry.
Caffeic acid phenethyl ester: A review on its pharmacological importance, and its association with free radicals, COVID‐19, and radiotherapy
Authors: Taysi Seyithan , Algburi Firas Shawqi , Taysi Muhammed Enes , Caglayan Cuneyt 
Published: December 2022

AbstractCaffeic acid phenethyl ester (CAPE), a main active component of propolis and a flavonoid, is one of the natural products that has attracted attention in recent years. CAPE, which has many properties such as anti‐cancer, anti‐inflammatory, antioxidant, antibacterial and anti‐fungal, has shown many pharmacological potentials, including protective effects on multiple organs. Interestingly, molecular docking studies showed the possibility of binding of CAPE with replication enzyme. In addition, it was seen that in order to increase the binding security of the replication enzyme and CAPE, modifications can be made at three sites on the CAPE molecule, which leads to the possibility of the compound working more powerfully and usefully to prevent the proliferation of cancer cells and reduce its rate. Also, it was found that CAPE has an inhibitory effect against the main protease enzyme and may be effective in the treatment of SARS‐CoV‐2. This review covers in detail the importance of CAPE in alternative medicine, its pharmacological value, its potential as a cancer anti‐proliferative agent, its dual role in radioprotection and radiosensitization, and its use against coronavirus disease 2019 (COVID‐19).
Fano resonances and slow light in a nanocavity assisted by metallic nanoparticles‐quantum dot system
Authors: Chen Chen , Wang Yaxue , Wang Wenjuan , Wang Shengjia , Xiahou Kuan , Yu Chunchao , Xiao Xun , Chen Fang , Zhang Huafeng , Sun Lihui 
Published: December 2022

AbstractDouble Fano resonances in a nanocavity assisted by metallic nanoparticles (MNPs)‐quantum dot (QD) system are demonstrated theoretically. The nanocavity is assumed to couple with the QD and QD is assumed to locate in the plasmon field produced by two excited MNPs nearby. The nanocavity is driven by a control field and a probing field. Double Fano resonances can be manipulated by the system parameters such as frequency detuning and coupling strength among the nanocavity, the mechanical oscillator, MNPs and QD. Especially, we find the second Fano resonance appears due to the interaction between the nanocavity with the QD‐MNPs. We also discuss the transmission and group delay in the double Fano resonance transparency windows which show tunable fast and slow light for different probe frequency. Our results may provide possible applications in designing optical buffer, switching, and so forth.
Anti‐unwinding nonsingular terminal sliding mode control with attitude maneuver planning for flexible spacecraft
Authors: Dong Rui‐Qi , Nagamune Ryozo , Wu Ai‐Guo 
Published: December 2022

AbstractIn this article, a novel control approach with a dynamic parameter and an attitude maneuver planning scheme is proposed for flexible spacecraft to achieve anti‐unwinding attitude maneuver control and vibration suppression. In order to suppress the flexible modal vibration of the flexible spacecraft during the attitude maneuver, an attitude maneuver path is planned by the proposed attitude maneuver planning scheme with four input impulses satisfying some conditions. For tracking the planned reference attitude maneuver path without unwinding phenomenon, a robust attitude maneuver controller with a dynamic parameter is proposed based on a novel switching function which contains terminal and non‐terminal sliding manifolds. Besides, the obtained sliding surface contains two equilibria. Finite‐time convergence and unwinding‐free performance of the closed‐loop system are analyzed by Lyapunov theory. The simulation results demonstrate that the proposed attitude control scheme possesses robustness and anti‐unwinding performance. Besides, the flexible vibration can be suppressed by tracking the planned attitude maneuver path.
Pruritus and Brain Tumours: A Prospective and Descriptive Study
Authors: Fardel Marie-Anne , Brenaut Emilie , Guellec Dewi , Etienne Maxime , Fouchard Maxime , Seizeur Romuald , Misery Laurent 
Published: December 2022

Abstract

Background
Pruritus, especially localised to the nostrils, has been reported as a specific sign of brain tumours.

Objectives
The main goal of this study was to estimate the prevalence of pruritus in a group of patients with brain tumours. The second outcome was to better characterise this pruritus with a specific questionnaire and a skin examination.

Methods
From June 2020 to September 2021, all patients with a diagnosis of brain tumour were included in this prospective, monocentric study. If the patient suffered from pruritus, a dermatological examination was performed.

Results
Two hundred patients with brain tumours were included. Thirty-five of them suffered from pruritus (17.5%). Among them, 15 patients did not present with any skin disease, and 8 could have neuropathic pruritus according to the NP5 questionnaire. No patients presented with pruritus of the nostrils.

Discussion
This study did not show clear evidence of specifically localised pruritus induced by brain tumours.

Conclusion
Pruritus observed in patients with brain tumours seems not to be caused by the brain malignancies in most cases. The specific localization to the nostrils cannot be considered a specific marker.
Bismuth‐catalyzed N‐Arylation of 2‐Aminobenzimidazole and Phosphorylation of Substituted Coumarins via C−H functionalization
Authors: Aamir Bin Riyaz M. , Swu T. 
Published: December 2022

AbstractThis work describes BiCl3’s catalytic activity in synthesizing N‐arylbenzimidazole and the phosphorylation of substituted coumarins with alkyl and aryl phosphites. This framework is utilized to synthesize a variety of 2‐aminobenzimidazole and coumarin derivatives in moderate to high yields under mild reaction conditions. The catalyst employed is highly productive, less hazardous, and inexpensive, making it desirable economically and environmentally.
The Next Frontier of 3D Bioprinting: Bioactive Materials Functionalized by Bacteria
Authors: Liu Yifei , Xia Xiudong , Liu Zhen , Dong Mingsheng 
Published: December 2022

Abstract3D bioprinting has become a flexible technical means used in many fields. Currently, research on 3D bioprinting is mainly focused on the use of mammalian cells to print organ and tissue models, which has greatly promoted progress in the fields of tissue engineering, regenerative medicine, and pharmaceuticals. In recent years, bacterial bioprinting has gradually become a rapidly developing research fields, with a wide range of potential applications in basic research, biomedicine, bioremediation, and other field. Here, this works reviews new research on bacterial bioprinting, and discuss its future research direction.
n‐Hexane Diluted Electrolyte with Ultralow Density enables Li–S Pouch Battery Toward >400 Wh kg−1
Authors: Cheng Hao , Zhang Shichao , Zhang Bing , Lu Yingying 
Published: December 2022

AbstractLithium–sulfur (Li‐S) batteries are attractive candidates for next generation energy storage devices due to their high theoretical energy density of up to 2600 Wh kg−1. However, the uneven deposition of lithium, the undesired shuttle of lithium polysulfides (LiPSs), and the excess weight fraction of electrolyte severely impair the practical energy density of Li‐S batteries. Here, a low concentrated and nonpolar n‐hexane (NH)‐diluted electrolyte (named as LCDE) with ultralow‐density to alleviate the above dilemmas is proposed. The nonpolar NH boosts the diffusion of lithium ion in LCDE, favoring the homogeneous deposition of lithium. This nonpolar effect also reduces the solubilities of LiPSs, promoting a quasi‐solid‐state transformation of sulfur chemistry, thus tremendously eradicating the shuttle of LiPSs. Most importantly, the ultra‐light NH diluent enables the LCDE with an ultralow density of only 0.79 g mL−1, which reduces the weight of LCDE by 32.5% compared with conventional ether‐based electrolyte. Owing to all the merits, the Li‐S pouch cell achieves a high energy density up to 417 Wh kg−1. The nonpolar NH‐diluted electrolyte with multifunction presented in this work provides a new and feasible direction to increase the practical energy density of Li‐S batteries.
Phage display for the detection, analysis, disinfection, and prevention of Staphylococcus aureus
Authors: Tian Lei , Jackson Kyle , Chan Michael , Saif Ahmed , He Leon , Didar Tohid F. , Hosseinidoust Zeinab 
Published: December 2022

AbstractThe World Health Organization has designated Staphylococcus aureus as a global health concern. This designation stems from the emergence of multiple drug‐resistant strains that already account for hundreds of thousands of deaths globally. The development of novel treatment strategies to eradicate S. aureus or mitigate its pathogenic potential is desperately needed. In the effort to develop emerging strategies to combat S. aureus, phage display is uniquely positioned to assist in this endeavor. Leveraging bacteriophages, phage display enables researchers to better understand interactions between proteins and their antagonists. In doing so, researchers have the capacity to design novel inhibitors, biosensors, disinfectants, and immune modulators that can target specific S. aureus strains. In this review, we highlight how phage display can be leveraged to design novel solutions to combat S. aureus. We further discuss existing uses of phage display as a detection, intervention, and prevention platform against S. aureus and provide outlooks on how this technology can be optimized for future applications.
Engineered Human Muscle Tissue from Multilayered Aligned Myofiber Sheets for Studies of Muscle Physiology and Predicting Drug Response
Authors: Takahashi Hironobu , Wakayama Haruno , Nagase Kenichi , Shimizu Tatsuya 
Published: December 2022

AbstractIn preclinical drug testing, human muscle tissue models are critical to understanding the complex physiology, including drug effects in the human body. This study reports that a multilayering approach to cell sheet‐based engineering produces an engineered human muscle tissue with sufficient contractile force suitable for measurement. A thermoresponsive micropatterned substrate regulates the biomimetic alignment of myofiber structures enabling the harvest of the aligned myofibers as a single cell sheet. The functional muscle tissue is produced by layering multiple myofiber sheets on a fibrin‐based gel. This gel environment promotes myofiber maturation, provides the tissue an elastic platform for contraction, and allows the attachment of a measurement device. Since this multilayering approach is effective in enhancing the contractile ability of the muscle tissue, this muscle tissue generates a significantly high contractile force that can be measured quantitatively. The multilayered muscle tissue shows unidirectional contraction from electrical and chemical stimulation. In addition, their physiological responses to representative drugs can be determined quantitatively in real time by changes in contractile force and fatigue resistance. These physiological properties indicate that the engineered muscle tissue can become a promising tissue model for preclinical in vitro studies in muscle physiology and drug discovery.
Rational Design of Advanced Triboelectric Materials for Energy Harvesting and Emerging Applications
Authors: Duan Qingshan , Peng Weiqing , He Juanxia , Zhang Zhijun , Wu Zecheng , Zhang Ye , Wang Shuangfei , Nie Shuangxi 
Published: December 2022

AbstractThe properties of materials play a significant role in triboelectric nanogenerators (TENGs). Advanced triboelectric materials for TENGs have attracted tremendous attention because of their superior advantages (e.g., high specific surface area, high porosity, and customizable macrostructure). These advanced materials can be extensively applied in numerous fields, including energy harvester, wearable electronics, filtration, and self‐powered sensors. Hence, designing triboelectric materials as advanced functional materials is important for the development of TENGs. Herein, the structural modification methods based on electrospinning to improve the triboelectric properties and the latest research progress in this kind of TENGs are systematically summarized. Preparation methods and design trends of nanofibers, microspheres, hierarchical structures, and doping nanomaterials are highlighted. The factors influencing the formation and properties of triboelectric materials are considered. Furthermore, the latest progress on the applications of TENGs is systematically elaborated. Finally, the challenges in the development of triboelectric materials are discussed, thereby guiding researchers in the large‐scale application of TENGs.
Integrated Gas Diffusion Electrode with High Conductivity Obtained by Skin Electroplating for High Specific Power Density Fuel Cell
Authors: Ning Fandi , Chai Zhi , Dan Xiong , Liu Pei , Wen Qinglin , Pan Saifei , He Can , Li Yali , Jin Hanqing , Li Wei , Xu Pengpeng , Chen Jiafan , Wei Jun , Zhou Xiaochun 
Published: December 2022

AbstractSmaller volume/weight and higher output power/energy density are always the goals of electrochemistry energy devices. Here, a simple strategy is proposed to prepare an integrated gas diffusion electrode (GDE) with high conductivity through skin electroplating. The skin electroplating is the combination of magnetron sputtering and spatial confinement electroplating. The electroplated metal obtained by skin electroplating is uniformly, continuously, and tightly attached to the surface of carbon paper like a layer of skin. Uniform and continuous electroplating metal layer endows the integrated electrode excellent conductivity with the square resistance as low as 27 mΩ sq−1. In application, the self‐breathing fuel cell with 1 cm2 active area can harvest ultrahigh volume specific power density (20.9 kW L−1). Additionally, the weight of the fuel cell stack (23 W) with the integrated electrode is only 20 g, which is only 7% of the commercial stack with the same power. The mass specific power density reaches 1150 W kg−1, which is 15 times of the commercial stack. Outstandingly, the stack can charge 4 mobile phones at the same time. More importantly, the skin electroplating provides an effective strategy to improve the specific power density of other energy devices including Zn‐air batteries, Li‐air batteries, and so on.