bluuebunny/crossref_metadata_2025_split huggingface dataset:
A hybrid multiobjective salp swarm algorithm enhanced with sine cosine operator and normal cloud model
Authors: Tang Jianxin , Gong Rizhao , Liu Yuxi 
Published: May 2023

Abstract
As a nature-inspired metaheuristic algorithm, salp swarm algorithm (SSA) still suffers from low searching efficiency and easily falling into local optimum, especially when solving composite problem. In order to enhance the performance of SSA, an improved SSA equipped with sine cosine algorithm and normal cloud generator (CSCSSA) is proposed in this paper. The sine and cosine operator can prevent the salp leader from ineffective search for possible food position, and speed up the search rate of SSA. In addition, the normal cloud generator is employed to replace the position update mechanismof salp followers, and enhance the diversity by generating cloud drops around the salp leader. Comprehensive comparison of CSCSSA and seven other optimization algorithms was conducted on CEC2017 benchmark functions. The statistical results and convergence curves prove that the CSCSSA can be considered as highly competitive algorithm according to the searching efficiency, convergence accuracy and the ability of local optimum avoidance.
Chromosome-level genome provides insights into environmental adaptability and innate immunity in the common dolphin (Delphinus delphis)
Authors: Ding Kui , Xu Qinzeng , Zhao Liyuan , Li Yixuan , Li Zhong , Shi Wenge , Zeng Qianhui , Wang Xianyan , Zhang Xuelei 
Published: May 2023

Abstract
The common dolphin (Delphinus delphis) is widely distributed worldwide and well adapted to various habitats. Animal genomes store clues about their pasts, and can reveal the genes underlying their evolutionary success. Here, we report the first high-quality chromosome-level genome of D. delphis. The assembled genome size was 2.56 Gb with a contig N50 of 63.85 Mb. Phylogenetically, D. delphis was located close to Tursiops truncatus and T. aduncus. The genome of D. delphis exhibited 428 expanded and 1,885 contracted gene families, and 120 genes were identified as positively selected. The expansion of the HSP70 gene family indicated that D. delphis has a powerful system for buffering stress, which might be associated with its broad adaptability, longevity, and detoxification capacity. The expanded IFN-α and IFN-ω gene families, as well as the positively selected genes encoding tripartite motif-containing protein 25, peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, and p38 MAP kinase, were all involved in pathways for antiviral, anti-inflammatory, and antineoplastic mechanisms. The genome data also revealed dramatic fluctuations in the effective population size during the Pleistocene. Overall, the high-quality genome assembly and annotation represent significant molecular resources for ecological and evolutionary studies of Delphinus and help support their sustainable treatment and conservation.
Calcium particle film shields sweet potato plants from abiotic stress
Authors: Ferreira Jacqueline Alves Borges , Oliveira Alexandre Passos , Júnior Luiz Fernando Ganassali de Oliveira , Milanez Camilla Rozindo Dias , Carnelossi Marcelo Augusto Gutierrez , Silva-Mann Renata 
Published: May 2023

Abstract
Abiotic stresses can cause significant harm to economically important crops, making it essential to adopt sustainable methods to mitigate their negative effects. One promising approach is particle film technology, which has been shown to alleviate the impact of water scarcity and solar radiation on crops. In this study, our goal was to determine the action of particle film used in leaves of Ipomoea batatas L. grown under varying water conditions. Our findings indicate that plants treated with the particle film suffered less harm to their photosynthetic systems, particularly during the reproductive stadium, regardless of the water regime. Furthermore, the exogenous application of the particle film resulted in increased photosynthetic efficiency and electron transport rates in plants, as well as a decrease in the chl a/b ratio and expression of the Cdc2a gene. These results demonstrate that particle film technology has the potential to enhance crop resilience and productivity in sweet potatoes, even in adverse conditions.
KLF14 inhibits tumor progression via FOSL1 in glioma
Authors: Wang Xiaohua , Qu Xinjuan , Liu Xuelai , Wang Kaiyue , Yang Yongfang , Zhang Yujuan , Wang Zhenguo , Li Yuming , Chen Hongwei 
Published: May 2023

Abstract
Background
Glioma is the most common malignancy of the central nervous system. Fos-like antigen 1 (FOSL1) is overexpressed and acts as a tumor-promoting factor in glioma. However, the regulation of FOSL1 remains unknown. KLF14, a member of Kruppel-like factors that are involved gene transcription, plays an important role in the regulation of cell proliferation, differentiation and apoptosis. Loss of KLF14 triggers spontaneous tumorigenesis of lung, spleen and lymph node, suggesting its potential as biomarker for cancer. However, its role in glioma still needs to be deciphered. Therefore, we explore the interactions between FOSL1 and KLF14, as well as their role in glioma.
Methods
We first determined that FOSL1 can be transcriptional inhibited by KLF14 using dual-luciferase reporter gene assays and qPCR assays. Then, through immunohistochemistry (IHC)assay and western blotting (WB) assay in glioma tissues, we demonstrated a negative correlation between FOSL1 and KLF14. Next, KLF14 knockdown cells and double knockdown of KLF14 and FOSL1 cells were generated, and cell growth were detected by different experimental methods (MTT assay, crystal violet staining, cell migration assay). We then used qPCR and WB assay to search for and validate how KLF14 affects tumor cell migration through FOSL1. Finally, we confirmed the inhibition of tumor growth by KLF14 using xenograft tumor model.
Results
In this study, we showed that KLF14 inhibited the transcription of FOSL1.There is a negative correlation between KLF14 and FOSL1 in glioma tissues. Overexpression of KLF14 reversed the effect of FOSL1 in cell invasion, migration and epithelial-mesenchymal transition in glioma cells, and this was accompanied by the down-regulation of Snail2 and CD44. Moreover, KLF14 overexpression inhibits tumor progression in vivo.
Conclusions
The present results suggest that KLF14 is a new tumor molecular marker and a potential target for the treatment of glioma, providing a new target for anti-tumor drug research.
Healthcare worker knowledge, attitudes, and beliefs regarding tuberculosis preventive therapy in rural South Africa: A content analysis using the consolidated framework for implementation research
Authors: de Water Brittney van , Wilson Michael , Roux Karl le , Gaunt Ben , Gimbel Sarah , Ware Norma 
Published: May 2023

Abstract
Background: South African national tuberculosis (TB) guidelines, in accordance with the World Health Organization, recommend conducting routine household TB contact investigation with provision of TB preventive therapy (TPT) for those who qualify. However, implementation of TPT has been suboptimal in rural South Africa. We sought to identify barriers and facilitators to TB contact investigations and TPT management in rural Eastern Cape, South Africa to inform the development of an implementation strategy to launch a comprehensive TB program.
Methods: We collected qualitative data through individual semi-structured interviews with 19 healthcare workers at a district hospital and four surrounding primary-care clinics referring to the hospital. The consolidated framework for implementation research (CFIR) was used to develop interview questions as well as guide deductive content analysis to determine potential drivers of implementation success or failure.
Results: A total of 19 healthcare workers were interviewed. Identified common barriers included lack of provider knowledge regarding efficacy of TPT, lack of TPT documentation workflows for clinicians, and widespread community resource constraints. Facilitators identified included healthcare workers high interest to learn more about the effectiveness of TPT, interest in problem-solving logistical barriers in provision of comprehensive TB care (including TPT), and desire for clinic and nurse-led TB prevention efforts.
Conclusion: The use of the CFIR, a validated implementation determinants framework, provided a systematic approach to identify barriers and facilitators to TB household contact investigation, specifically the provision and management of TPT in this rural, high TB burden setting. Specific resources – time, trainings, and evidence – are necessary to ensure healthcare providers feel knowledgeable and competent about TPT prior to prescribing it more broadly. Tangible resources such as improved data systems coupled with political coordination and funding for TPT programming are essential for sustainability.
A new hybrid model for photovoltaic output power prediction
Authors: Zou Jing , Wei Menghan , Song Qixian , Zhou Zhaorong 
Published: May 2023

Abstract
Recently, with the development of renewable energy technologies, photovoltaic (PV) power generation is widely used in the grid. However, as PV power generation is influenced by external factors, such as solar radiation fluctuation, PV output power is intermittent and volatile, and thus the accurate PV output power prediction is imperative for the grid stability. To address this issue, the artificial rabbits optimization is firstly improved by various strategies, then based on convolutional neural network and bidirectional long short-term memory (CBiLSTM) with improved artificial rabbits optimization (IARO), a new hybrid model denoted by IARO-CBiLSTM is proposed to predict PV output power. Moreover, inputs of IARO-CBiLSTM are optimized by analyzing influential factors of PV output power with Pearson correlation coefficient method. Finally, in order to verify the prediction accuracy, IARO-CBiLSTM is compared with other well-known methods under different weather conditions and different seasons, and the compared results show that IARO-CBiLSTM performs better in terms of various evaluation metrics.
Productivity of Different Nutrient Management Systems under Diverse Rice-Based Crop Rotations in the Dry Zone of Sri Lanka
Authors: Wickramasinghe W. M. D. M. , Devasinghe D.A.U.D , Suriyagoda L.D.B , Egodawatta W C P , Benaragama D.I.D.S 
Published: May 2023

Abstract

Alternative nutrient management options have improved with many synergistic processes of spatial and temporal scale leading to sustained and stabilized productivity due to concerns over the irregular and uneven application of mineral fertilizers. However, understanding the productivity dynamics of biomass and yield in diverse nutrient management and crop rotation intensities is important. This study was conducted during the transitional period with conventional (CONV), integrated (INT), and organic (ORG) nutrient management under four crop diversification intensities in a dry zone of Sri Lanka. Mono-cropped rice (LOW) and a rice-maize rotation (HIGH) were the starting point. After 1 year, the intensity of diversification was increased by adding interseason sunnhemp (rice-sunnhemp-rice; MEDIUM and rice-sunnhemp-maize; VERY HIGH). The INT LOW system during the 1st cycle was very effective. Crop biomass (41%), final grain yield (28%), and rice equivalent yield (36%) increased with the ORG LOW system than at ORG HIGH system. In the 2nd cycle, there was a higher grain yield (54%) and a higher rice equivalent yield (53%) in the ORG HIGH than ORG LOW. The productivity under VERY HIGH rotation was similar in ORG, INT, and CONV towards the end of two-year study. Halving the amount of mineral fertilizers and compensating with organic fertilizers maintains the productivity of existing crops without losing their full reliance on mineral fertilizers. Increasing the diversity from rice mono-cropping to rice-sunnhemp-maize cropping system delivered better synergy by improving overall productivity and grain yields in the organic system. This provides details for new farming system designs combined with ecological and sustainable pathways.
HAHNet: A convolutional neural network for HER2 status classification of breast cancer
Authors: Wang Jiahao , Zhu Xiaodong , Chen Kai , Hao Lei , Liu Yuanning 
Published: May 2023

Abstract
Background: Breast cancer is a major health problem for women. Human epidermal growth factor receptor-2 (HER2) is a very important diagnostic and prognostic factor for breast cancer, and HER2 status classification is essential for the development of treatment plans for breast cancer. Generally speaking, pathologists will adopt immunohistochemistry (IHC) to assess HER2 status, which requires additional economic costs. Furthermore, the manual assessment of HER2 status is time-consuming and error-prone. In recent years, deep learning has been widely used in medical field and has attained great achievements. However, the existing deep learning methods for HER2 status classification of conventional hematoxylin and eosin (H&E) stained images are not accurate enough.
Results: To address these problems, a neural network model named HAHNet is proposed in this paper. HAHNet combines multi-scale features with attention mechanisms, which is able to directly classify HER2 status of H&E stained histological images of breast cancer. Typically, the HAHNet network mainly includes convolution preprocessing, attention mechanism, downsampling, and multi-scale feature extraction. The experimental results show that HAHNet outperforms other existing methods with regard to six metrics of Accuracy, Sensitivity, Precision, F-score, MCC, and AUC.
Conclusions: Collectively, the above experiments demonstrate that our proposed HAHNet achieves high performance in classifying the HER2 status of breast cancer using only H&E stained samples, which can be used in case classification and helps to reduce the cost required for diagnosis.
24 h combined esophageal multichannel intraluminal impedance and pH monitoring in children with chronic cough
Authors: Gan Yi , Zhou Xiaoqin , Huang Zhaoxvan , Gao Shan , Wang Guirong , Gu Li , Zhang Di , Yan Lingzhi , Shang Shanshan , Tu Danna , Shu Junhua 
Published: May 2023

Abstract

Background
Chronic cough in children is closely related to gastroesophageal reflux. However, this association has not been adequately studied owing to a lack of diagnostic tools. Combined multichannel intraluminal impedance and pH (MII-pH) monitoring is considered the most accurate method for evaluating the association between symptoms and reflux, but data on its use in children with chronic cough are lacking. We aimed to assess the association between chronic cough and gastroesophageal reflux in children through MII-pH monitoring.
Methods
Children with chronic cough were selected to undergo 24-h MII-pH monitoring at our hospital. Patients were divided into two groups according to their age and reflux index (RI), and the differences between the groups were analyzed.
Results
Overall, 426 patients were included. The median age was 12 months (interquartile range: 6–39.5 months), and 129 patients (30.3%) had RI＞7%. Gastroesophageal reflux predominantly occurred in the upright position andmostly involved weakly acidic reflux and mixed gas-liquid reflux. Impedance reflux events did not show any difference between groups (p＜0.01).
Conclusion
The presence of acid and non-acid reflux in children can be detected through 24 h MII-pH monitoring, which is valuable for diagnosing gastroesophageal reflux disease and reflux-related cough.
Vitreous management in Yamane’s technique for crystalline lens dislocation: anterior vitrectomy or PPV?
Authors: Tang Yong , Yao Shiqi , Chu Yanhua , Han Quanhong 
Published: May 2023

Abstract
Objective
To study the postoperative visual outcomes and surgical complications of anterior/pars plana vitrectomy and concurrent Yamane’s IOL fixation for crystalline lens dislocation.
Methods
53 patients (56 eyes) with crystalline lens subluxation/dislocation were enrolled in this retrospective interventional study. Patients received anterior/pars plana vitrectomy and concurrent Yamane’s IOL fixation. Main outcome measures were postoperative BCVA and surgical complications. Proportion of spontaneous PVD and preoperative undetected retinal holes/degeneration (PURH/D) were recorded.
Results
24 eyes were treated with anterior vitrectomy (Group AnV) and 32 eyes with pars plana vitrectomy (Group PPV). Overall incidence of PURH/D was 10.7% (6/56). Spontaneous PVD occurred in 68.8% (24/32) in Group PPV. During six months follow-up, one case of postoperative RRD and one case of choroidal detachment occurred in Group AnV. There was no significant difference between anterior vitrectomy and PPV in the final BCVA and postoperative complications.
Conclusion
Anterior or pars plana vitrectomy, which are both applicable in YAMANE technique for crystalline lens dislocation, exhibit similar surgical outcomes. Patient’s age, PVD status and PURH helps to determine the route of vitrectomy. Pediatric patients might be potential candidates for transcorneal vitreolensectomy. For adult, PURH managed with total vitrectomy and intraoperative lase retinopexy might be beneficial to decrease the incidence of postoperative RRD.
Fault diagnosis method for unbalance data based on Gramian angular field
Authors: yu ping , Li Rong-bin , Cao student , Qin Jun-hua 
Published: May 2023

Abstract
The commonplace practice in deep learning is to make use of a balanced dataset, whereby the number of fault data is equivalent to that of normal data. However, in the context of real-world applications, the number of fault data is generally insufficient compared to that of normal data. In this study, a new approach for diagnosing faults in unbalanced data sets is proposed using the Gramian Angular Field(GAF) method. Firstly, the Gramian Angular Field (GAF) method is employed to convert one-dimensional data into two-dimensional data, which enhances the feature extraction process. Secondly, to balance the sample distribution, fault data is generated using Generative Adversarial Networks (GANs).Finally, the residual neural network (ResNet) with an attention mechanism is utilized to improve the accuracy of fault diagnosis. The proposed method was experimentally validated using open-source bearing datasets that were published by Case Western Reserve University and the University of Ottawa. The experimental results show that the proposed method has greatly improved fault diagnosis performance in cases of data distribution imbalance, surpassing that of the compared methods.
Strigolactones might regulate ovule development after fertilization in Xanthoceras sorbifolium
Authors: Zhou Qingyuan , Zhou Linyi , Cai Qing 
Published: May 2023

Abstract
Background Strigolactones (SLs) were recently defined as a novel class of plant hormones that act as key regulators of diverse developmental processes and environmental responses. Much research has focused on SL biosynthesis and signaling in roots and shoots, but little is known about whether SLs are produced in early developing seeds and about their roles in ovule development after fertilization. Results The fertilized ovules and early developing pericarp in Xanthoceras sorbifolium produced minute amounts of two strigolactones: 5-deoxystrigol and strigol. Their content decreased in the plants with the addition of exogenous phosphate (Pi) compared to those without Pi treatment. Exogenous application of an SL analog (GR24) and a specific inhibitor of SL biosynthesis (TIS108) affected early seed development and fruit set. We identified a total of 69 putative Xanthoceras homologs of genes related to SL biological synthesis and signaling in the Xanthoceras genome. The expression of these genes in the ovules after fertilization was profiled using RNA-seq, resulting in the identification of 37 genes that were differentially expressed between the normally developing ovules and senescing ovules after fertilization. Transcriptome analysis also revealed that 12 putative invertase genes were actively expressed in normally developing ovules after fertilization. Hexoses (glucose and fructose) accumulated at high concentrations in normally developing ovules during syncytial endosperm development. In contrast, a low ratio of hexose and sucrose levels was detected in senescing ovules with a high strigolactone content. Virus-induced gene silencing (VIGS)-mediated XsD14 gene silencing increased hexose content in fertilized ovules and induced proliferation of endosperm free nuclei, thereby promoting early seed development and fruit set. Conclusion SLs are produced in early developing seeds and may play an important role in regulating ovule development after fertilization. The crosstalk between sugar and strigolactone signals may be an important part of a system that accurately regulates senescence of ovules after fertilization. This study is useful for understanding the mechanisms underlying ovule senescence, which will serve as a guide for genetic or chemical approaches to promote seed yield in Xanthoceras.
Dynamic studies of binary adsorption system in fixed beds
Authors: Olafadehan Olaosebikan Abidoye , Amoo Kehinde Olawale , Oyedeko Kamilu Folorunsho Kayode , Adesina Ayo Joshua 
Published: May 2023

Abstract
In this study, a generalized, comprehensive and feasible mathematical model was developed for the description of the adsorption of multicomponent system in a fixed bed containing solid adsorbent. It took into cognizance of all the factors considered negligible in the literature, which included intraparticle, interparticle and interphase diffusional resistances, conditions of non-equilibrium and non-linear binary adsorption of butan-2-ol and 2-methylbutan-2-ol onto activated carbon. The resulting 4N hyperbolic and parabolic differential equations were numerically solved using orthogonal collocation on finite element method. Excellent agreements were achieved between the experimental data and the simulated results of breakthrough times and concentrations of the solutes in fixed beds of 0.41, 0.82 and 1.23 m. Equally, the observed chromatographic tops of the less strongly adsorbed component (butan-2-ol) and the effects of adsorber length on times of breakthrough of the components and height of peaks were precisely simulated. The results of this study are of beneficial use in the design and analysis of fixed beds employed for the treatment of multicomponent aqueous wastewater effluents from industry.
Multiple mitogenomes indicate Things Fall Apart with Out of Africa or Asia hypotheses for the phylogeographic diversity of Honey Bees (Apis mellifera)
Authors: Carr Steven M 
Published: May 2023

Abstract
Previous morpho-molecular studies of evolutionary relationships within the economically important genus of honey bees (Apis), including the Western Honey Bee (A. mellifera L.), have suggested Out of Africa or Asia origins and subsequent spread to Europe. I test these hypotheses by a meta-analysis of complete mitochondrial DNA coding regions (11.0 Kbp) of 22 nominal subspecies represented by 74 individual sequences of A. mellifera. Parsimony, distance, and likelihood analyses identify six nested clades: Things Fall Apart with Out of Africa or Asia hypotheses. Phylogeographic analysis shows instead a basal origin of A. m. mellifera in Europe ~780 Kya, and extension to Southeast Europe and Asia Minor ~720 Kya. European bees spread southward via a Levantine / Nilotic / Arabian corridor into Africa ~540 Kya. A circum- Mediterranean clade was re-established in Iberia ~100 Kya, and thence back through the Mediterranean islands into North Africa. Paraphyletic anomalies are artefacts of mis-referral in GenBank of sequences to the wrong subspecies, which are clarified by inclusion of multiple individuals from each subspecies. Further errors arise from reliance on faulty sequences and (or) methods of inference. Nominal subspecies within the Asia Minor and Mediterranean clades are less differentiated than are individuals within other subspecies.