bluuebunny/crossref_metadata_2025_split huggingface dataset:
Real‐world treatment and outcome patterns of patients with mantle cell lymphoma in China: A large, multicenter retrospective analysis
Authors: Yang Ping , Cai Qing‐qing , Zhang Wei , Liu Shuo‐zi , Liu Hui , Sun Xiu‐hua , Dong Yu‐jun , Xiao Xiu‐bin , Wang Jing‐wen , Li Zhen‐ling , Huang Wen‐rong , Li Li‐hong , Bao Hui‐zheng , Yang Wei , Wang Ya‐lan , Wang Shu‐ye , He Juan , Li Xiao‐ling , Liu Ai‐chun , Jing Hong‐mei 
Published: May 2023

AbstractBackgroundMantle cell lymphoma (MCL) is an uncommon heterogeneous subtype of B cell non‐Hodgkin lymphoma, and clinical features in MCL appear regional characteristics. MCL treatment opinions are not uniform between countries or regions within Asia and China, and Asian patient‐specific data for MCL treatment are fewer. The study aims to explore the clinical characteristics, treatment patterns and prognosis of MCL patients in China.MethodsA total of 805 patients diagnosed with MCL between April 1999 and December 2019 at 19 comprehensive hospitals in China were included in this retrospective analysis. Kaplan‐Meier method coupled with the log‐rank test was used for univariate analysis, and COX proportional hazards model was used for multivariate analysis (MVA). p < 0.05 was consided statistically significant. All outputs were produced using R version 4.1.0.ResultsThe median age of the cohort was 60.0 years with a male‐to‐female ratio of 3.36:1. Five‐year progression‐free survival (PFS) and overall survival (OS) rates were 30.9% and 65.0%, respectively. High‐intermediate/high‐risk group according to MIPI‐c, without high‐dose cytarabine, lack of Auto‐SCT as consolidation and maintenance treatment and SD/PD in initial treatment remained statistically relevant to poor PFS on MVA, and ki67 ≥50%, B symptoms, high‐intermediate/high risk group according to MIPI‐c, without high‐dose cytarabine, lack of maintenance treatment, SD/PD in initial treatment and relapse/refractory state were independently associated with poorer OS on MVA.ConclusionsFirst‐line high dose cytarabine exposure, auto‐SCT as consolidation therapy obtained survival benefits in Chinese population. Our study further confirmed the value of maintenance treatment and explored the application of new drug treatment and bendamustine in R/R MCL patients.
Synthesis of Pogostone‐Inspired Dehydroacetic Acid Derivatives and Their Antifungal Activity against Sclerotinia sclerotiorum (Lib.) de Bary
Authors: Wang Delong , Yuan Chunxia , Li Jing , Fang Yali , Zhang Zhijia 
Published: May 2023

AbstractIn an effort to exploit the natural antifungal pogostone, its simplified scaffold dehydroacetic acid (DHA) was used as a lead compound to semi‐synthesize 56 DHA derivatives (I1–48, II, III, and IV1–6). Among them, compound IV4 exhibited the most potent antifungal activity with 11.0 μM EC50 against mycelial growth of Sclerotinia sclerotiorum (Lib.) de Bary whose sclerotia production was also completely suppressed at this concentration. Furthermore, IV4 could completely inhibit infection cushion formation of S. sclerotiorum on rape leaves and achieved a preventive efficacy of 90.2 % at 500 μM, which was on the same level as that of commercial boscalid at 30 μM (88.7 %). The results of physiological and ultrastructural studies indicated that IV4 might disrupt the cell membrane permeability or induce the imbalance of mitochondrial membrane potential homeostasis to exert the antifungal mode of action. Besides, the robust and predicative three‐dimensional quantitative structure‐activity relationship (3D‐QSAR) models were developed and discussed herein.
Preparation and Characterization of a Silk Fibroin/Polyurethane Fiber Blend Membrane Containing Actinomycin X2 with Excellent Mechanical Properties and Enhanced Antibacterial Activities
Authors: Zhang Quan , Chen Fengyun , Javeed Ansar , Wang Miaofeng , Si Ranran , Li Jiaxing , Han Bingnan 
Published: May 2023

AbstractDevelopment of suitable antimicrobial biomaterials for hygienic wound dressing and healing is an important requirement for medical application. Durable mechanical properties increase the application range of biomaterial in different environmental and biological conditions. Due to the inherent brittleness of silk fibroin (SF), polyurethane fiber (PUF) was used to modify SF containing actinomycin X2 (Ac.X2) to prepare silk fibroin@actinomycin X2/polyurethane fiber (ASF/PUF) blend membranes. The ASF/PUF blend membrane was developed by solution casting method. Incorporation of PUF improved the flexibility of material and introduction of Ac.X2 has increased antibacterial activity of materials. Excellent mechanical properties (tensile strength up to 25.7 MPa and elongation at break up to 946.5 %) of 50 % SF+50 % PUF blend membrane were proved by tensile testing machine. FT‐IR spectra, TGA, contact angle and DMA were tested to prove the blend membrane's physico‐chemical characteristics. ASF/PUF blend membrane displayed satisfactory antibacterial activity against S. aureus, and the cytotoxicity tests showed that the blend membrane has better biosafety compared to directly applied Ac.X2 in soluble form. These results suggest that the modification of SF through PUF for development of flexible antibacterial membranes has great potential application value in the field of silk‐like material fabrication.
Secondary Amine‐Mediated Domino Reaction for the Synthesis of Substituted Quinolines from Dicyanoalkenes and Enynals
Authors: Hayashi Yujiro , Han Xiaolei , Mori Naoki 
Published: May 2023

AbstractSubstituted quinolines, tricyclic and tetracyclic molecules with a quinoline moiety are synthesized by a domino reaction from dicyanoalkenes and 3‐aryl‐pent‐2‐en‐4‐ynals in one pot. We established two methods: one is catalyzed by chiral diphenylprolinol silyl ether, and the other is catalyzed by di(2‐ethyl)hexylamine, in combination withp‐nitrophenol. A wide variety of dicyanoalkenes can be employed. As the catalysts are secondary amines, and water is the only by‐product, this is an environmentally benign synthetic method for the preparation of substituted quinolines.
Impact of Faradaic Interlayer Confinement and Carbon‐Centered Macrostructure Designs for Ion Capture and the Recovery of Elements
Authors: Patil Rahul , Das Dipak Kumar , Dutta Saikat 
Published: May 2023

AbstractEnvironmental protection associated with renewable energy is among the most critical challenges for translational ion‐capture based on capacitive storage of ions in electrical double layers at the interface of electrode and electrolyte. Electric double‐layer capacitance with charge induction and faradaic pseudo‐capacitance with charge transfer classifies the capacitance of the electrochemical interface. The electrochemical interface in most energy technologies involves porous and pseudocapacitive redox materials that offer varying degrees of electrolyte confinement. In this review, we discuss the factors affecting water desalination, such as the effect of nanopores for ion capture, the ion sieving effect, the effect of hydration energy, and hydration radius in the carbon sub‐nanometer pore. Moreover, the surface phenomena of electrodes, including carbon corrosion, and the potential of zero charge to control the oxidation of carbon electrodes are explained along with protection mechanisms. The various capacitive deionization (CDI) operations and the corresponding electrochemical cell technologies are briefly introduced, including the significance of double‐layer charging materials with faradaic intercalation, which suffer less from co‐ion expulsion. Finally, we revisit the effects of various nanoarchitectures and the construction of capacitive deionization electrodes for clean water technology.
Oral lesions in human monkeypox disease and their management
Authors: Joseph Betsy , Anil Sukumaran 
Published: May 2023

AbstractObjective: The current outbreak of human monekypox (MPX) in several endemic and non‐endemic regions in 2022 has generated significant international attention. Despite the early classification as zoonotic, MPXV has demonstrated the potential for human‐to‐human transmission through close contact with lesions, body fluids, respiratory droplets, and contaminated materials. Therefore, our objective was to elaborate on the oral lesions in human MPX and their management.Materials and Method: Articles published up to August, 2022, were screened to identify relevant studies in humans that reported oral lesions in MPX.Results: Oral lesions have been found to manifest differently and transform from vesicles to pustules, accompanied by umbilication and crusting within four weeks. Along with fever and lymphadenopathy, these lesions may develop in the oral cavity and then spread to the skin surrounding the extremities in a centrifugal pattern. In some patients, the oropharyngeal and perioral lesions were the initial presentations.Conclusions: The oral lesions of MPX infection and its management strategies are relevant for dentists. Dental practitioners may be the first to detect the initial lesions of MPX. Therefore, high alertness should be there, especially while examining patients with fever and lymphadenopathy. It is also essential to thoroughly examine the oral cavity for macular and papular lesions in oral mucosa, tongue, gingiva, and epiglottis. Symptomatic and supportive care of oral lesions is recommended.
Protect, respect, remedy, and report? Development of human rights reporting in the context of formal institutional settings
Authors: Hubers Frank , Thijssens Thomas 
Published: May 2023

AbstractThis paper investigates the influence of formal institutions, in particular legislation, on corporate human rights (HR) reporting. We use a mixed‐method approach, combining qualitative institutional analysis of two European countries — the Netherlands and Switzerland — with quantitative content analysis of annual reports of 94 listed companies for the years 2007 to 2019 (1222 firm‐years). We find that, for each observed book year, companies in the Netherlands are more willing to disclose HR information than companies in Switzerland, which we explain by their differences in formal institutional development. Our results indicate that formal institutions are essential determinants in HR reporting, both in the willingness of companies to disclose and the extensiveness of disclosure. Moreover, we observe a significant positive impact of legislation on HR reporting but find that the overall compliance levels of affected companies are low. We contribute to prior research, by providing evidence on the development and institutional drivers of HR reporting, a largely overlooked branch of sustainability reporting.
Synthesis of Azoxy Compounds: from Copper Compounds to Mesoporous Silica‐Encaged Ultrasmall Copper Catalysts
Authors: Han Zhi‐Peng , Wang Shiqi , Sun Qiming , Xu Xiao‐Ping , Ji Shun‐Jun 
Published: May 2023

AbstractAzoxy compounds have aroused extensive attention due to their unique biological activities, but the chemical synthesis of these compounds often suffers from limitations due to their requirement for stoichiometric oxidants, high costs, and restricted substrate range. Herein, a series of azoxy compounds were constructed via facile coupling reactions by using cost‐effective N‐methoxyformamide and nitroso compounds over Cu‐based catalysts, affording high product yields with excellent tolerance of functional groups. Significantly, the mesoporous silica nanosphere‐encapsulated ultrasmall Cu (Cu@MSN) catalyst was developed via a one‐pot synthetic method and first used for the synthesis of azoxy compounds. As compared with copper salt catalysts, the Cu@MSN catalyst exhibited remarkably enhanced catalytic activity and superior recycling stability. Such a Cu@MSN catalyst overcame the inherent drawbacks of low activity, fast deactivation, and difficult recycling of traditional metal salt catalysts in organic reactions. This work provides a green and efficient method for the construction of azoxy compounds and also creates new prospects for the application of nanoporous materials confined metal catalysts in organic synthesis.
Simplified selective harmonic elimination PWM for three‐level five‐phase T‐NPC inverter
Authors: Bennacer Nassim Rayane , Bentafat Mahdi , Benachour Ali , Sekhri Sabri , Berkouk El Madjid 
Published: May 2023

SummaryThis paper presents a selective harmonic PWM strategy (HSE‐PWM) to control a five‐phase three‐level T‐NPC inverter. The proposed method aims to reduce switching losses and directly eliminate specific orders of harmonics, while also controlling the fundamental magnitude. MATLAB/Simulink simulations are conducted using an RL load, and the implementation is tested using a simplified method on an STM32F4 controller board. Experimental tests are then carried out to validate the simulation results. Additionally, power losses and efficiency are studied using Plecs software. The paper explores four different cases of switching angles number and proposes three SHE methods: a simple SHE based on Newton Raphson's method, SHE with current THD optimization, and SHE with common mode voltage (CMV) optimization using the PSO algorithm. The proposed methods provide complete control over the fundamental of the output voltage and the selected harmonics while reducing switching losses. A comparison is carried out in terms of voltage waveform, maximum CMV, fundamental magnitude, total harmonic distortion (THD), and power efficiency for the three methods. The paper concludes that the proposed modulation can be useful in high‐power applications.
Role of vitreous cytology in the diagnosis of primary central nervous system lymphoma: A report of an unusual presentation
Authors: Tom Jesty Pullattu , Gupta Parikshaa , Radotra Bishan Das , Gupta Nalini , Takkar Aastha , Singh Sofia , Gupta Vishali 
Published: May 2023

AbstractPrimary central nervous system lymphoma (PCNSL) is a rare subtype of non‐Hodgkin lymphoma confined to the brain, spinal cord, meninges, intraocular compartment, and cranial nerves. Intraocular lymphoma (IOL) is a rare subtype of PCNSL. Intravitreal involvement by a PCNSL is an infrequent but potentially fatal event. The role of vitreous cytology in diagnosing IOLs is vital but has been sporadically described in the literature due to its variable sensitivity. Herein, we present a case of PCNSL, who primarily presented with ocular symptoms and could be accurately diagnosed based on vitreous cytology and subsequently confirmed on stereotactic brain biopsy.
Drivers of power line collisions and electrocutions of birds in Nepal
Authors: Hamal Suman , Sharma Hari Prasad , Gautam Ramji , Katuwal Hem Bahadur 
Published: May 2023

AbstractAmong the several anthropogenic factors, power lines are increasingly regarded as one of the most significant hazards to bird species, primarily owing to collisions and electrocutions. Nepal has comparatively fewer studies on the impact of power line collisions and electrocution on birds compared with developed nations. From November 2021 to May 2022, we assessed the effect of power line collisions and electrocutions on the mortality of birds in the Putalibazar Municipality of the Syangja district of Nepal. We established 117 circular plots in diverse habitats, including agricultural lands, forests, settlements, and river basins, along a 30.6 km long distribution line. Within 18 plots, we detected 43 fatalities of 11 species (17 individuals of six species due to collision and 26 individuals of eight species due to electrocution). House Swift (Apus nipalensis) and Common Myna (Acridotheres tristis) were the primary victims of the collision, whereas House Crow (Corvus splendens) and Rock Pigeon (Columba livia) were frequently observed electrocuted. We also recorded the electrocution of the critically endangered White‐rumped Vulture (Gyps bengalensis). The total rate of bird power line collisions per kilometer was 0.55 birds, while the total electrocution rate per 10 poles was 2.22. The bird abundance, distance to agricultural regions, and proximity to human settlements were found to have a strong relationship with the mortality of birds caused by power lines. In order to reduce power line collisions and electrocution fatalities, we recommend conducting a detailed bird population study prior to determining the route of distribution lines.
Determinants of stunting among children under age five in Burundi: Evidence from the 2016–2017 Burundi Demographic and Health Survey (BDHS 2016–17)
Authors: Gaiser Manuel L. , Winkler Andrea S. , Klug Stefanie J. , Nkurunziza Sandra , Stelzle Dominik 
Published: May 2023

AbstractBurundi has one of the highest prevalence of stunting in the world. This study aimed to identify determinants of stunting among children under age five in Burundi. A total of 4993 children with anthropometric measurements from the 2016–2017 Burundi Demographic and Health Survey were included in the study. Stunting was assessed from the height‐for‐age Z‐scores (HAZ). Logistic regression models were analyzed to identify demographic, maternal, child‐related, and structural variables that influence stunting. In total, 56.9% of children under age five were stunted, of those 31.0% moderately and 25.9% severely. Multivariable logistic regression indicated that older children, male children (adjusted OR (aOR) = 1.41, 95% CI 1.24–1.61), and children who were perceived as small (aOR = 2.00, 95% CI 1.55–2.59) or very small at birth (aOR = 2.37, 95% CI 1.57–3.59) were significantly more likely to be stunted. Moreover, children of single mothers, with lower levels of education, who were underweight at the time of the survey (aOR = 1.95, 95% CI 1.42–2.68), who had short stature (aOR = 3.76, 95% CI 2.50–5.66) or who conceived more than four children (aOR = 1.22, 95% CI 1.05–1.42) were more commonly stunted. Stunting was more prevalent in rural areas (aOR = 2.53, 95% CI 1.72–3.73) and in households with no access to improved types of toilet facilities (aOR = 1.27, 95% CI 1.10–1.45). The results of this study show that the prevalence of stunting in children under age five in Burundi is alarmingly high and underscores the urgent need for decisive and determined action.
Enhancement of iron‐based oxygen carriers through alloying with tungsten oxide for chemical looping applications including water splitting
Authors: Morales Corona Jose Juan , Sedransk Campbell Kyra , Fennell Paul S. 
Published: May 2023

AbstractChemical looping applications offer a variety of options to decarbonise different industrial sectors, such as iron and steel and hydrogen production. Chemical looping with water splitting (CLWS) is a chemical looping technology, which produces H2 while simultaneously capturing CO2. The selection of oxygen carriers (OCs) available to be used in CLWS is finite, due to the thermodynamic limitations of the oxidation with steam for different materials at the relevant process temperatures. Iron‐based materials are one of the most widely studied options for chemical looping combustion (CLC), touted for their relative abundance and low cost; likewise, for CLWS, iron is the most promising option. However, when the reduction of iron oxide (Fe2O3) is extended to wüstite (FeO) and iron (Fe), agglomeration and sintering problems are the main challenge for fluidisation.This work presents iron and tungsten mixed oxides as the OCs for a family of chemical looping applications. The OCs were produced via co‐precipitation; performance assessment was conducted in a thermogravimetric analyser and a lab‐scale fluidised bed reactor over continuous redox cycles. The use of tungsten combined with iron results in a solid solution of tungsten within the Fe2O3 matrix that produced a more mechanically stable material during operation, which performed well during multiple redox cycles with no apparent decrease in the oxygen transport capacity and showed no apparent agglomeration. Furthermore, materials containing tungsten showed a resistance to carbon deposition, whereas the reference Fe2O3 showed peaks of CO and CO2 during the oxidation period, thus indicating carbon deposition. © 2023 Society of Chemical Industry and John Wiley & Sons, Ltd.
Young versus older subject diffusion magnetic resonance imaging data for virtual white matter lesion tractography
Authors: Taghvaei Mohammad , Cook Philip , Sadaghiani Shokufeh , Shakibajahromi Banafsheh , Tackett William , Dolui Sudipto , De Debarun , Brown Christopher , Khandelwal Pulkit , Yushkevich Paul , Das Sandhitsu , Wolk David A. , Detre John A. 
Published: May 2023

AbstractWhite matter hyperintensity (WMH) lesions on T2 fluid‐attenuated inversion recovery (FLAIR) magnetic resonance imaging (MRI) and changes in adjacent normal‐appearing white matter can disrupt computerized tract reconstruction and result in inaccurate measures of structural brain connectivity. The virtual lesion approach provides an alternative strategy for estimating structural connectivity changes due to WMH. To assess the impact of using young versus older subject diffusion MRI data for virtual lesion tractography, we leveraged recently available diffusion MRI data from the Human Connectome Project (HCP) Lifespan database. Neuroimaging data from 50 healthy young (39.2 ± 1.6 years) and 46 healthy older (74.2 ± 2.5 years) subjects were obtained from the publicly available HCP‐Aging database. Three WMH masks with low, moderate, and high lesion burdens were extracted from the WMH lesion frequency map of locally acquired FLAIR MRI data. Deterministic tractography was conducted to extract streamlines in 21 WM bundles with and without the WMH masks as regions of avoidance in both young and older cohorts. For intact tractography without virtual lesion masks, 7 out of 21 WM pathways showed a significantly lower number of streamlines in older subjects compared to young subjects. A decrease in streamline count with higher native lesion burden was found in corpus callosum, corticostriatal tract, and fornix pathways. Comparable percentages of affected streamlines were obtained in young and older groups with virtual lesion tractography using the three WMH lesion masks of increasing severity. We conclude that using normative diffusion MRI data from young subjects for virtual lesion tractography of WMH is, in most cases, preferable to using age‐matched normative data.
International cooperation in irrigation and drainage—Putting people at the heart of what we do
Authors: Maywald Hon Karlene 
Published: May 2023

AbstractThe N.D. Gulhati Memorial Lecture has been organized by the International Commission on Irrigation and Drainage in collaboration with the Gulhati Trust since 1981 in honour of the visionary water resources engineer Er. Niranjan Das Gulhati, the driving force behind the establishment of the International Commission on Irrigation and Drainage. In this paper it is stated that the lofty goal of innovation in irrigation and water and sustainability cannot be achieved through an engineering‐only approach. The allied aspects of sustainable environmental management and societal behavioural change have to be taken into account as well to enable the global irrigation communities to embrace the reforms necessary to make a difference and underpin a prosperous and inclusive society for all. Examples are given how such an approach would be possible.