bluuebunny/crossref_metadata_2025_split huggingface dataset:
Strategi Bisnis Dalam Keunggulan Bersaing Terhadap Peningkatan Penjualan Pada Sisik Melik Batik Banyu-wangi
Authors: Rosyidah Elok , Romadloni Sahru 
Published: March 2023

: Berbagai industri batik semakin bermunculan serta menampilkan keunggulan bersaing yang berbeda, mulai dari motif, bahan baku, proses produksi, strategi pemasaran serta berbagai elemen yang mendukungnya. Sisik melik semakin dikenal oleh masyarakat luas melalui ciri khasnya. Kualitas produk dan inovasi produk baru serta pemasaran yang diimplementasikan mengakibatkan terjadinya peningkatan penjualan di Sisik melik. Inovasi dapat menjadi salah satu faktor agar bisa bertahan pada pasar dengan memberikan nilai plus di atas industri batik lainnya. Penjualan suatu industri di atas rata-rata pesaing lainnya dapat dimiliki jika melalui keunggulan bersaing. Penelitian ini bertujuan untuk menganalisis strategi bisnis dalam keunggulan bersaing terhadap peningkatan penjualan produk Sisik melik Batik Banyuwangi. Penelitian ini menggunakan pendekatan deskriptif kualitatif. Data dikumpulkan melalui teknik observasi, wawancara serta dokumentasi. Hasil penelitian menunjukkan bahwa citra dan produk merupakan strategi diferensiasi dalam penelitian ini, sedangkan inovasi produk dan inovasi pemasaran adalah inovasi dalam penelitian ini. Strategi diferensiasi serta inovasi dalam upaya peningkatan penjualan Sisik melik dapat dibuktikan dari data jumlah penjualan yang meningkat selama tahun 2021 serta dapat mempertahankan diri pada posisi pasar persaingan.
Pkm Peningkatan Kosa Kata Siswa Bahasa Inggris Dengan Games Untuk Menunjang Kemahiran Bahasa Inggris Anak – Anak Tingkat SD Di Lembang Marante, Kecamatan Sopai, Toraja Utara.
Authors: Lukas Lukas , Tandikombong Matius 
Published: March 2023

Kegiatan ini dilaksanakn dilembang Marante selama 6 bulan mulai dari bulan juni –November 2022. Kegiatan ini diikuti oleh 40 peserta yang dibagi kedalam dua kelompok. Pelaksanaan kegiatan dilaksanakn di dua tempat yaitu di kantor lembang Marante dan di rumah kepala dusun Marante pada sore hari. Kegiatan ini dilaksanakan 3 kali dalam seminggu yaitu pada hari senin, rabu dan sabtu. Dari hasil Kegiatan pengabdian kepada masyarakat (PKM) telah berjalan dengan baik dan memberikan hasil yang positif. Dari hasil yang ditemukan setalah melakukan bimbingan belajar menunjukkan bahwa ternyata pengajaran kosa kata bahasa Inggris menggunakan Games memberikan dampak yang positif. Hal ini dapat dilihat darai hasil pre-test dan post test. Hasil post-test lebih besar dibandingkan dengan pre-test. Juga dengan hasil wawancara dengan peserta menunjukkan bahaw pembelajaran menggunakan game membuat mereka termotivasi dan bersemagat belajar bahasa inggris. Selain itu, mereka juga merasa tidak tegang dan cenderung lebih santai dalam mengikuti pembelajaran. Kegiatan ini juga disambut positif oleh s masyarakat lembang Marante.
PERAN POS BANTUAN HUKUM DALAM MELAKUKAN PENDAMPINGAN HUKUM KEPADA TERDAKWA SELAMA MASA PANDEMI COVID-19
Authors: Rahmadiana Annisa , Lies Sulistiani  , Ajie Ramdan  
Published: March 2023

Abstrak
Memperoleh pendampingan hukum merupakan salah satu hak yang dimiliki oleh seorang terdakwa ketika menjalani proses peradilan. Pemberian bantuan hukum kepada terdakwa selama masa pandemi Covid-19 sedikit banyak mengalami kendala. Beralihnya mekanisme pendampingan hukum selama masa Pandemi Covid-19 yang dahulu dilaksanakan tatap muka secara langsung menjadi daring menggunakan perantara alat elektronik dianggap memicu munculnya hambatan dan kendala bagi Posbakum untuk melakukan pendampingan hukum secara optimal kepada terdakwa. Berdasarkan hal tersebut, Penelitian ini dilakukan untuk mencari tahu sejauh mana peran Posbakum sebagai penyedia layanan hukum cuma-cuma di pengadilan dan efektivitas pelaksanaan pemberian bantuan hukum yang dilakukan oleh Posbakum kepada terdakwa selama masa Pandemi Covid-19. Penelitian dilakukan menggunakan metode yuridis empiris, sehingga permasalahan tidak hanya dilihat secara normatif, tetapi juga melihat bagaimana kenyataan yang terjadi di lapangan secara langsung. Data lapangan didapatkan melalui hasil observasi dan wawancara dengan beberapa narasumber yang memiliki keterlibatan dengan proses pemberian bantuan hukum. Hasil penelitian menunjukkan bahwa pelaksanaan pemberian bantuan hukum yang dilakukan oleh Posbakum Pengadilan Cibinong selama masa Pandemi Covid-19 belum sepenuhnya efektif karena dalam pelaksanaannya masih menemukan kendala-kendala yang menjadikan pendampingan hukum tidak dapat diberikan secara optimal, sebagai akibat dari keterbatasan interaksi dan komunikasi antara penasihat hukum dengan terdakwa dan ketiadaan sarana atau prasarana yang kurang mumpuni.
Kata Kunci: Bantuan Hukum, Posbakum, Terdakwa
PENERAPAN MODEL PROBLEM BASED LEARNING MENINGKATKAN HASIL BELAJAR MATEMATIKA SISWA SMP NEGERI 1 RANTEPAO
Authors: Aprianti Eka - , Sumargiyani Sumargiyani 
Published: March 2023

This research is a classroom action research that aims to determine student learning outcomes after implementing the action through a problem based learning. The subjects of this study were class VIII.1 students of SMP Negeri 1 Rantepao in the Even Semester of the 2021/2022 Academic Year with a total of 31 students consisting of 5 boys and 26 girls. This research was carried out in two cycles where each cycle was carried out in two meetings including tests at the end of each cycle. Data collection was carried out by means of learning outcomes tests at the end of each cycle, and observations were made each time the learning process took place. The results obtained after the implementation of the action through the problem based learning two cycles are: a) Improving student learning outcomes. This can be seen from the increase in the average score of mathematics learning outcomes, namely in the first cycle of 77.51 with classical learning mastery of 67.7% then increasing in the second cycle to 85.16 with classical learning mastery of 87%. b) An increase in student activity in the learning process in accordance with the results of observations made during the study. From the results of the analysis it can be concluded that the problem based learning can improve the mathematics learning outcomes of class VIII.1 students of SMP Negeri 1 Rantepao.
Superelastic Carbon Aerogels: An Emerging Material for Advanced Thermal Protection in Extreme Environments
Authors: Chang Xinyi , Cheng Xiaota , Zhang Hao , Li Wenjing , He Lijuan , Yin Xia , Liu Xiaoyan , Yu Jianyong , Liu Yi‐Tao , Ding Bin 
Published: March 2023

AbstractCarbon aerogels (CAs) are desirable for thermal protection in aerospace because of their lightweight and high‐temperature insulation characteristic; however, their intrinsic brittleness and flaw sensitivity easily trigger catastrophic failure when resisting high‐frequency thermal shocks or complex mechanical stresses. Compression is the predominant load applied on aerogels by aerodynamic pressure and pre‐tightening force; therefore, the structural elasticity and exceptional capability to keep thermal performance under impact stress are crucial in deciding the actual availability of aerogels. This review presents the recent progress in newly resilient CAs for thermal protection, focusing on reliable structural stability, thermal stability, and thermal superinsulation property. The influence law of microstructures on heat transfer behaviors is first investigated, followed by construction strategies for adiabatic CAs, emphasizing the recoverable deformability resulting from increased continuity of building blocks from 0D nanoparticles to 1D nanofibers/nanotubes and then to 2D nanosheets. Moreover, the optimization of thermal stability in high‐temperature aerobic environments and thermal insulation performance are discussed. Finally, it raises current challenges and further opportunities for CAs toward better properties and brighter prospects.
Carrier Localization on the Nanometer‐Scale limits Transport in Metal Oxide Photoabsorbers
Authors: Schleuning Markus , Kölbach Moritz , Ahmet Ibbi , Präg Raphael , Gottesman Ronen , Gunder René , Zhang Mengyuan , Wargulski Dan Ralf , Abou‐Ras Daniel , Grave Daniel A. , Abdi Fatwa F. , van de Krol Roel , Schwarzburg Klaus , Eichberger Rainer , Friedrich Dennis , Hempel Hannes 
Published: March 2023

AbstractMetal oxides are considered as stable and low‐cost photoelectrode candidates for hydrogen production by photoelectrochemical solar water splitting. However, their power conversion efficiencies usually suffer from poor transport of photogenerated charge carriers, which has been attributed previously to a variety of effects occurring on different time and length scales. In search for common understanding and for a better photo‐conducting metal oxide photoabsorber, CuFeO2, α‐SnWO4, BaSnO3, FeVO4, CuBi2O4, α‐Fe2O3, and BiVO4 are compared. Their kinetics of thermalization, trapping, localization, and recombination are monitored continuously 100 fs–100 µs and mobilities are determined for different probing lengths by combined time‐resolved terahertz and microwave spectroscopy. As common issue, we find small mobilities < 3 cm2V‐1s‐1. Partial carrier localization further slows carrier diffusion beyond localization lengths of 1–6 nm and explains the extraordinarily long conductivity tails, which should not be taken as a sign of long diffusion lengths. For CuFeO2, the localization is attributed to electrostatic barriers that enclose the crystallographic domains. The most promising novel material is BaSnO3, which exhibits the highest mobility after reducing carrier localization by annealing in H2. Such overcoming of carrier localization should be an objective of future efforts to enhance charge transport in metal oxides.
Double Cross‐Linked Biomimetic Hyaluronic Acid‐Based Hydrogels with Thermo‐Stimulated Self‐Contraction and Tissue Adhesiveness for Accelerating Post‐Wound Closure and Wound Healing
Authors: Zhao Yaodong , Yi Bingcheng , Hu Jilin , Zhang Dongjie , Li Guotai , Lu Yun , Zhou Qihui 
Published: March 2023

AbstractWhen skin trauma occurs, rapid achievement of the post‐wound closure is required to prevent microbial invasion, inhibit scar formation and promote wound healing. To develop a wound dressing for accelerating post‐wound‐closure and wound healing, a thermo‐responsive and tissue‐adhesive hydrogel with interpenetrating polymer networks (IPN) is fabricated based on N‐dimethylbisacrylamide (NIPAM) and glutaraldehyde (GTA) cross‐linked hyaluronic acid (HA). Results not only confirm the thermo‐stimulated self‐contraction and tissue adhesiveness of the HA‐based IPN (PNI‐HA), which effectively aids wound closure via mechanical stretch, but also verify the hemocompatibility and cytocompatibility of PNI‐HA that tend to accelerate wound healing. In vivo, a mouse model of total skin defect demonstrates that PNI‐HA acting as hydrogel sealant significantly achieves the sutureless post‐wound‐closure at the early stage of wound healing, and then promotes wound healing by reducing inflammatory cells infiltration, promoting angiogenesis as well as reducing collagen deposition. These results indicate that the developed thermo‐responsive and tissue‐adhesive hydrogel dressing offers a candidate to serve as a tissue sealant for wound healing.
Nano‐Strategies for Lignin Biomaterials toward Cancer Therapy
Authors: Sathasivam Thenapakiam , Kai Jing , Sugiarto Sigit , Yu Yong , Soo Debbie Xiang Yun , Zhu Qiang , Merzaban Jasmeen , Kai Dan 
Published: March 2023

AbstractLignin is a nontoxic and biocompatible biopolymer with many promising characteristics, including a high tensile strength and antioxidant properties. This natural polymer can be processed through several chemical methods and modified into lignin nanomaterials for potential biomedical applications. This review summarizes the latest developments in nanolignin (NL)‐based biomaterials for cancer therapy; various NL applications related to cancer therapy are considered, including drug and gene delivery, biosensing, bioimaging, and tissue engineering. The manuscript also outlines the potential use of these materials to improve the therapeutic potency of chemotherapeutic drugs by decreasing their dose and reducing their adverse effects. Due to its high surface area‐to‐volume ratio and the easy modification of its chemical components, NL could serve as an appropriate matrix for the binding and controlled release of various pharmaceutical agents. Moreover, the challenges in the utilization of NL‐based materials for cancer therapy are discussed, along with the prospects of advances in such nanomaterials for medical research applications.
Zinc‐Based Tannin‐Modified Composite Microparticulate Scaffolds with Balanced Antimicrobial Activity and Osteogenesis for Infected Bone Defect Repair
Authors: Zhao Yitao , Li Jintao , Liu Lingli , Wang Yue , Ju Yan , Zeng Chun , Lu Zhihui , Xie Denghui , Guo Jinshan 
Published: March 2023

AbstractTreatment of infected bone defects is a major clinical challenge; bioactive materials combining sufficient antimicrobial activity and favorable osteogenic ability are urgently needed. In this study, through a facile one‐pot hydrothermal reaction of zinc acetate in the presence of tannic acid (TA), with or without silver nitrate (AgNO3), is used to synthesize a TA or TA and silver nanoparticles (Ag NPs) bulk‐modified zinc oxide (ZnO) (ZnO‐TA or ZnO‐TA‐Ag), which is further composited with zein to fabricate porous microparticulate scaffolds for infected bone defect repair. Bulk TA modification significantly improves the release rate of antibacterial metal ions (Zn2+ release rate is >100 times that of ZnO). Fast and long‐lasting (>35 d) Zn2+ and Ag+ release guaranteed sufficient antibacterial capability and excellent osteogenic properties in promoting the osteogenic differentiation of bone marrow mesenchymal stem cells and endogenous citric acid production and mineralization and providing considerable immunomodulatory activity in promoting M2 polarization of macrophages. At the same time, synchronously‐released TA could scavenge endogenous reactive oxygen species (ROS) and ROS produced by antibacterial metal ions, effectively balancing antibacterial activity and osteogenesis to sufficiently control infection while protecting the surrounding tissue from damage, thus effectively promoting infected bone defect repair.
Organic Persistent RTP Crystals: From Brittle to Flexible by Tunable Self‐Partitioned Molecular Packing
Authors: Huang Arui , Fan Yuanyuan , Wang Kun , Wang Zhengzhi , Wang Xiyan , Chang Kai , Gao Yuan , Chen Mingzhou , Li Qianqian , Li Zhen 
Published: March 2023

AbstractAiming to solve the trade‐off of “room‐temperature phosphorescence (RTP)–flexibility” in principle, organic RTP crystals with elastic/plastic deformation are realized. These properties are mainly due to the divisional aggregation structures of aromatics and alkoxy chains, and can be modulated by the controllable molecular configurations. The longest RTP lifetime of 972.3 ms is achieved as the highest record for organic flexible crystals. Plastic crystals with persistent RTP are realized, which can be applied into biomedical optical technologies by afterglow delivery. Moreover, the relationship among elastic/plastic deformation, RTP property, and aggregated structures is established. The elastic/plastic deformation is mainly determined by the difference of interaction energies from the aromatics and the alkoxy chains. For the BP‐OR series with twisted configurations, the alkoxy chain with the middle length is favorable for the RTP property, while the strength of the π–π coupling is the cruical factor to the RTP property of the Xan‐OR series with planar skeletons. A new way to promote the development of flexible RTP crystals, by modulation of aggregated structures as well as rational distribution of intermolecular interactions, is explored.
Ablation of Gap Junction Protein Improves the Efficiency of Nanozyme‐Mediated Catalytic/Starvation/Mild‐Temperature Photothermal Therapy
Authors: Li Yongjuan , Zhang Yu , Dong Ya , Akakuru Ozioma Udochukwu , Yao Xiaohan , Yi Jinmeng , Li Xinyan , Wang Linlin , Lou Xiaohan , Zhu Baoyu , Fan Kelong , Qin Zhihai 
Published: March 2023

AbstractReactive oxygen species (ROS)‐mediated tumor catalytic therapy is typically hindered by gap junction proteins that form cell‐to‐cell channels to remove cytotoxic ROS, thereby protecting tumor cells from oxidative damage. In this work, a multifunctional nanozyme, FePGOGA, is designed and prepared by Fe(III)‐mediated oxidative polymerization (FeP), followed by glucose oxidase (GOx) and GAP19 peptides co‐loading through electrostatic and π–π interactions. The FePGOGA nanozyme exhibits excellent cascade peroxidase‐ and glutathione‐oxidase‐like activities that efficiently catalyze hydrogen peroxide conversion to hydroxyl radicals and convert reduced glutathione to oxidized glutathione disulfide. The loaded GOx starves the tumors and aggravates tumor oxidative stress through glucose decomposition, while GAP19 peptides block the hemichannels by inducing degradation of Cx43, thus increasing the accumulation of intracellular ROS, and decreasing the transport of intracellular glucose. Furthermore, the ROS reacts with primary amines of heat shock proteins to destroy their structure and function, enabling tumor photothermal therapy at the widely sought‐after mild temperature (mildPTT, ≤45 °C). In vivo experiments demonstrate the significant antitumor effectof FePGOGA on cal27 xenograft tumors under near‐infrared light irradiation. This study demonstrates the successful ablation of gap junction proteins to overcome resistance to ROS‐mediated therapy, providing a regulator to suppress tumor self‐preservation during tumor starvation, catalytic therapy, and mildPTT.
Self‐Organization of Iron Sulfide Nanoparticles into Complex Multicompartment Supraparticles
Authors: Turali‐Emre E. Sumeyra , Emre Ahmet E. , Vecchio Drew A. , Kadiyala Usha , VanEpps J. Scott , Kotov Nicholas A. 
Published: March 2023

AbstractSelf‐assembled compartments from nanoscale components are found in all life forms. Their characteristic dimensions are in 50–1000 nm scale, typically assembled from a variety of bioorganic “building blocks”. Among the various functions that these mesoscale compartments carry out, protection of the content from the environment is central. Finding synthetic pathways to similarly complex and functional particles from technologically friendly inorganic nanoparticles (NPs) is needed for a multitude of biomedical, biochemical, and biotechnological processes. Here, it is shown that FeS2 NPs stabilized by l‐cysteine self‐assemble into multicompartment supraparticles (mSPs). The NPs initially produce ≈55 nm concave assemblies that reconfigure into ≈75 nm closed mSPs with ≈340 interconnected compartments with an average size of ≈5 nm. The intercompartmental partitions and mSP surface are formed primarily from FeS2 and Fe2O3 NPs, respectively. The intermediate formation of cup‐like particles enables encapsulation of biological cargo. This capability is demonstrated by loading mSPs with DNA and subsequent transfection of mammalian cells. Also it is found that the temperature stability of the DNA cargo is enhanced compared to the traditional delivery vehicles. These findings demonstrate that biomimetic compartmentalized particles can be used to successfully encapsulate and enhance temperature stability of the nucleic acid cargo for a variety of bioapplications.
Graphene Biointerface for Cardiac Arrhythmia Diagnosis and Treatment
Authors: Lin Zexu , Kireev Dmitry , Liu Ning , Gupta Shubham , LaPiano Jessica , Obaid Sofian N. , Chen Zhiyuan , Akinwande Deji , Efimov Igor R. 
Published: March 2023

AbstractHeart rhythm disorders, known as arrhythmias, cause significant morbidity and are one of the leading causes of mortality. Cardiac arrhythmias are frequently treated by implantable devices, such as pacemakers and defibrillators, or by ablation therapy guided by electroanatomical mapping. Both implantable and ablation therapies require sophisticated biointerfaces for electrophysiological measurements of electrograms and delivery of therapeutic stimulation or ablation energy. In this work, a graphene biointerface for in vivo cardiac electrophysiology is reported for the first time. Leveraging sub‐micrometer‐thick tissue‐conformable graphene arrays, sensing and stimulation of the open mammalian heart are demonstrated both in vitro and in vivo. Furthermore, the graphene biointerface treatment of atrioventricular block (the kind of arrhythmia where the electrical conduction from the atria to the ventricles is interrupted) is demonstrated. The graphene arrays show effective electrochemical properties, namely interface impedance down to 40 Ω cm2at 1 kHz, charge storage capacity up to 63.7 mC cm−2, and charge injection capacity up to 704 µC cm−2. Transparency of the graphene structures allows for simultaneous optical mapping of cardiac action potentials, calcium transients, and optogenetic stimulation while performing electrical measurements and stimulation. The report presents evidence of the significant potential of graphene biointerfaces for advanced cardiac electrophysiology and arrhythmia therapy.
Electrochemical Biomass Upgrading Coupled with Hydrogen Production under Industrial‐Level Current Density
Authors: Qian Qizhu , He Xiaoyue , Li Ziyun , Chen Yanxu , Feng Yafei , Cheng Mingyu , Zhang Huaikun , Wang Wentao , Xiao Chong , Zhang Genqiang , Xie Yi 
Published: March 2023

AbstractAs promising hydrogen energy carrier, formic acid (HCOOH) plays an indispensable role in building a complete industry chain of a hydrogen economy. Currently, the biomass upgrading assisted water electrolysis has emerged as an attractive alternative for co‐producing green HCOOH and H2 in a cost‐effective manner, yet simultaneously affording high current density and Faradaic efficiency (FE) still remains a big challenge. Here, the ternary NiVRu‐layered double hydroxides (LDHs) nanosheet arrays for selective glycerol oxidation and hydrogen evolution catalysis are reported, which yield an industry‐level 1 A cm−2 at voltage of 1.933 V, meanwhile showing considerable HCOOH and H2 productivities of 12.5 and 17.9 mmol cm−2 h−1, with FEs of almost 80% and 96%, respectively. Experimental and theoretical results reveal that the introduced Ru atoms can tune the local electronic structure of Ni‐based LDHs, which not only optimizes hydrogen adsorption kinetics for HER, but also reduces the reaction energy barriers for both the conversion of NiII into GOR‐active NiIII and carboncarbon (CC) bond cleavage. In short, this work highlights the potential of large‐scale H2 and HCOOH productions from integrated electrocatalytic system and provides new insights for designing advanced electrocatalyst for low‐cost and sustainable energy conversion.