bluuebunny/crossref_metadata_2025_split huggingface dataset:
Changing adolescent activity patterns and the correlation of self-esteem and externalizing mental health symptoms across time: results from the USA from 1991 through 2020
Authors: Kreski Noah T. , Askari Melanie S. , Cerdá Magdalena , Chen Qixuan , Hasin Deborah S. , Martins Silvia S. , Mauro Pia M. , Olfson Mark , Keyes Katherine M. 
Published: May 2023

AbstractBackgroundCommon adolescent psychiatric symptoms cluster into two dominant domains: internalizing and externalizing. Both domains are linked to self-esteem, which serves as a protective factor against a wide range of internalizing and externalizing problems. This study examined trends in US adolescents' self-esteem and externalizing symptoms, and their correlation, by sex and patterns of time use.MethodsUsing Monitoring the Future data (N = 338 896 adolescents, grades:8/10/12, years:1991–2020), we generated six patterns of time use using latent profile analysis with 17 behavior items (e.g. sports participation, parties, paid work). Groups were differentiated by high/low engagement in sports and either paid work or high/low peer socialization. Within each group, we mapped annual, sex-stratified means of (and correlation between) self-esteem and externalizing factors. We also examined past-decade rates of change for factor means using linear regression and mapped proportions with top-quartile levels of poor self-esteem, externalizing symptoms, or both.ResultsWe found consistent increases in poor self-esteem, decreases in externalizing symptoms, and a positive correlation between the two across nearly all activity groups. We also identified a relatively constant proportion of those with high levels of both in every group. Increases in poor self-esteem were most pronounced for female adolescents with low levels of socializing, among whom externalizing symptoms also increased.ConclusionsRising trends in poor self-esteem are consistent across time use groups, as is the existence of a group facing poor self-esteem and externalizing symptoms. Effective interventions for adolescents' poor self-esteem/co-occurring symptoms are needed broadly, but especially among female adolescents with low peer socialization.
Precise positioning in a robotized laser-cutting machine allowed by a three-V-shaped-groove kinematic coupling: a feasibility study
Authors: De Benedictis Carlo , Ferraresi Carlo 
Published: May 2023

AbstractDevices known as kinematic couplings offer accurate, repeatable, and stiff connections between two parts. They are characterized by point contacts and enable great repeatability with errors less than 1 micron, in contrast to conventional coupling systems like alignment pins or those based on elastic deformation. In this study, a robotized laser-cutting machine is equipped with a three-groove kinematic coupling design to increase the precision of workpiece placement. Given the application’s requirements, a preliminary design of the coupling is defined. An analytical approach is provided for calculating stresses and deflections at the locations where balls and grooves make contact, and it is then utilized to calculate positioning errors caused by the mechanical structure’s elastic deformation under various loading conditions. The outcomes of the simulations are finally discussed and highlight the efficacy of the solution tested.
Minding Rights: Mapping Ethical and Legal Foundations of ‘Neurorights’
Authors: Ligthart Sjors , Ienca Marcello , Meynen Gerben , Molnar-Gabor Fruzsina , Andorno Roberto , Bublitz Christoph , Catley Paul , Claydon Lisa , Douglas Thomas , Farahany Nita , Fins Joseph J. , Goering Sara , Haselager Pim , Jotterand Fabrice , Lavazza Andrea , McCay Allan , Wajnerman Paz Abel , Rainey Stephen , Ryberg Jesper , Kellmeyer Philipp 
Published: May 2023

AbstractThe rise of neurotechnologies, especially in combination with artificial intelligence (AI)-based methods for brain data analytics, has given rise to concerns around the protection of mental privacy, mental integrity and cognitive liberty – often framed as “neurorights” in ethical, legal, and policy discussions. Several states are now looking at including neurorights into their constitutional legal frameworks, and international institutions and organizations, such as UNESCO and the Council of Europe, are taking an active interest in developing international policy and governance guidelines on this issue. However, in many discussions of neurorights the philosophical assumptions, ethical frames of reference and legal interpretation are either not made explicit or conflict with each other. The aim of this multidisciplinary work is to provide conceptual, ethical, and legal foundations that allow for facilitating a common minimalist conceptual understanding of mental privacy, mental integrity, and cognitive liberty to facilitate scholarly, legal, and policy discussions.
A DNA-PK phosphorylation site on MET regulates its signaling interface with the DNA damage response
Authors: Koch Jonas P. , Roth Selina M. , Quintin Aurélie , Gavini Jacopo , Orlando Eleonora , Riedo Rahel , Pozzato Chiara , Hayrapetyan Liana , Aebersold Ruedi , Stroka Deborah M. , Aebersold Daniel M. , Medo Matúš , Zimmer Yitzhak , Medová Michaela 
Published: May 2023

AbstractThe DNA damage response (DDR) is intertwined with signaling pathways downstream of oncogenic receptor tyrosine kinases (RTKs). To drive research into the application of targeted therapies as radiosensitizers, a better understanding of this molecular crosstalk is necessary. We present here the characterization of a previously unreported MET RTK phosphosite, Serine 1016 (S1016) that represents a potential DDR-MET interface. MET S1016 phosphorylation increases in response to irradiation and is mainly targeted by DNA-dependent protein kinase (DNA-PK). Phosphoproteomics unveils an impact of the S1016A substitution on the overall long-term cell cycle regulation following DNA damage. Accordingly, the abrogation of this phosphosite strongly perturbs the phosphorylation of proteins involved in the cell cycle and formation of the mitotic spindle, enabling cells to bypass a G2 arrest upon irradiation and leading to the entry into mitosis despite compromised genome integrity. This results in the formation of abnormal mitotic spindles and a lower proliferation rate. Altogether, the current data uncover a novel signaling mechanism through which the DDR uses a growth factor receptor system for regulating and maintaining genome stability.
Conditional survival in multiple myeloma and impact of prognostic factors over time
Authors: Abdallah Nadine H. , Smith Alexandra N. , Geyer Susan , Binder Moritz , Greipp Patricia T. , Kapoor Prashant , Dispenzieri Angela , Gertz Morie A. , Baughn Linda B. , Lacy Martha Q. , Hayman Suzanne R. , Buadi Francis K. , Dingli David , Hwa Yi L. , Lin Yi , Kourelis Taxiarchis , Warsame Rahma , Kyle Robert A. , Rajkumar S. Vincent , Kumar Shaji K. 
Published: May 2023

AbstractOverall survival estimates from diagnosis are valuable for guiding treatment, but do not consider the years already survived. Conditional survival (CS) provides dynamic survival predictions over time. This study was conducted to estimate CS at 1–8 years from diagnosis and the impact of baseline prognostic factors on CS in multiple myeloma (MM) patients. This is a retrospective study including 2556 MM patients diagnosed between 2004 and 2019. CS (t | s) was defined as the probability of surviving t years given survival of s years. Median age was 64 years. Median follow-up was 6.2 years and median overall survival from diagnosis was 7.5 years. The 5-year CS estimates at s = 0, 1, 2, 3, and 5 years were 0.64, 0.61, 0.61, 0.61, and 0.58, respectively. On multivariate analysis, age ≥ 65 and proteasome inhibitor+immunomodulatory-based induction were associated with decreased survival and increased survival, respectively, retained at 5 years. The adverse impact of 1q gain/amplification, high-risk IgH translocation, and ISS-3 was significant at 1 and 3 years but not 5 years. Chromosome 17 abnormality was associated with decreased survival only at 1 year. Among MM patients, 5-year CS was stable at 1–5 years from diagnosis. The prognostic impact of high-risk cytogenetic factors decreased with additional years survived.
Broadening the phenotypic and molecular spectrum of FINCA syndrome: Biallelic NHLRC2 variants in 15 novel individuals
Authors: Sczakiel Henrike L. , Zhao Max , Wollert-Wulf Brigitte , Danyel Magdalena , Ehmke Nadja , Stoltenburg Corinna , Damseh Nadirah , Al-Ashhab Motee , Balci Tugce B. , Osmond Matthew , Andrade Andrea , Schallner Jens , Porrmann Joseph , McDonald Kimberly , Liao Mingjuan , Oppermann Henry , Platzer Konrad , Dierksen Nadine , Mojarrad Majid , Eslahi Atieh , Bakaeean Behnaz , Calame Daniel G. , Lupski James R. , Firoozfar Zahra , Seyedhassani Seyed Mohammad , Mohammadi Seyed Ahmad , Anwaar Najwa , Rahman Fatima , Seelow Dominik , Janz Martin , Horn Denise , Maroofian Reza , Boschann Felix 
Published: May 2023

AbstractFINCA syndrome [MIM: 618278] is an autosomal recessive multisystem disorder characterized byfibrosis,neurodegeneration andcerebralangiomatosis. To date, 13 patients from nine families with biallelicNHLRC2variants have been published. In all of them, the recurrent missense variant p.(Asp148Tyr) was detected on at least one allele. Common manifestations included lung or muscle fibrosis, respiratory distress, developmental delay, neuromuscular symptoms and seizures often followed by early death due to rapid disease progression.Here, we present 15 individuals from 12 families with an overlapping phenotype associated with nine novelNHLRC2variants identified by exome analysis. All patients described here presented with moderate to severe global developmental delay and variable disease progression. Seizures, truncal hypotonia and movement disorders were frequently observed. Notably, we also present the first eight cases in which the recurrent p.(Asp148Tyr) variant was not detected in either homozygous or compound heterozygous state.We cloned and expressed all novel and most previously published non-truncating variants in HEK293-cells. From the results of these functional studies, we propose a potential genotype-phenotype correlation, with a greater reduction in protein expression being associated with a more severe phenotype.Taken together, our findings broaden the known phenotypic and molecular spectrum and emphasize thatNHLRC2-related disease should be considered in patients presenting with intellectual disability, movement disorders, neuroregression and epilepsy with or without pulmonary involvement.
Endothelial-derived complement factor D contributes to endothelial dysfunction in malignant nephrosclerosis via local complement activation
Authors: Wang Zheng , Zhang Zhe , Li Yuan , Zhang Ying , Wei Min , Li Hui , Yang Shanzhi , Zhou Yali , Zhou Xinjin , Xing Guolan 
Published: May 2023

AbstractMalignant nephrosclerosis is a thrombotic microangiopathy associated with abnormal local activation of the complement alternative pathway (AP). However, the mechanism underlying local AP activation is not fully understood. We hypothesized that complement factor D (CFD) secreted by endothelial cells triggers vascular dysfunction in malignant nephrosclerosis via local complement activation. We investigated the deposition of CFD in human kidney biopsy tissues and the function of endothelial-derived CFD in endothelial cell cultures. Immunofluorescence microscopy and laser microdissection-targeted mass spectrometry revealed significant deposition of CFD in the kidneys of patients with malignant nephrosclerosis. Conditionally immortalized human glomerular endothelial cells (CiGEnCs) continuously expressed and secreted CFD in vitro. CFD knockdown in CiGEnCs by small interfering RNA reduced local complement activation and attenuated the upregulation of intercellular adhesion molecule-1 (ICAM-1), vascular adhesion molecule-1 (VCAM-1), von Willebrand factor (VWF), and endothelin-1 (ET-1) induced by Ang II. The expression of CFD in CiGEnCs was significantly higher than that in other types of microvascular endothelial cells. Our findings suggest that (i) glomerular endothelial cells are an important source of local renal CFD, (ii) endothelial-derived CFD can activate the local complement system, and (iii) endothelial-derived CFD mediates endothelial dysfunction, which may play a role in the pathogenesis of malignant nephrosclerosis.
Anatomic considerations of inflatable penile prosthetics: lessons gleaned from surgical body donor workshops
Authors: Osmonov D. , Wilson S. K. , Heinze T. , Heimke M. , Novak J. , Ragheb A. , Köhler T. , Hatzichristodoulou G. , Wedel T. 
Published: May 2023

AbstractSurgical implantation of an inflatable penile prosthesis (IPP) remains the gold-standard treatment for severe erectile dysfunction. The ideal surgical technique requires a thorough understanding of the relevant anatomy. This includes anatomic considerations related to, but not limited to, dissection and exposure of penoscrotal fasciae and tissues, corporal configuration, and abdominal structures. Insights obtained from pre-dissected anatomic specimens can obviate urethral injury, nerve damage, corporal perforation, inappropriate sizing, crossover, or implant malposition. We present penile implant-specific anatomic dissections and topographic landmarks identified over the last decade in the course of surgical training programs provided for IPP implantation.
Fast rotating blue stragglers prefer loose clusters
Authors: Ferraro Francesco R. , Mucciarelli Alessio , Lanzoni Barbara , Pallanca Cristina , Cadelano Mario , Billi Alex , Sills Alison , Vesperini Enrico , Dalessandro Emanuele , Beccari Giacomo , Monaco Lorenzo , Mateo Mario 
Published: May 2023

AbstractBlue stragglers are anomalously luminous core hydrogen-burning stars formed through mass-transfer in binary/triple systems and stellar collisions. Their physical and evolutionary properties are largely unknown and unconstrained. Here we analyze 320 high-resolution spectra of blue stragglers collected in eight galactic globular clusters with different structural characteristics and show evidence that the fraction of fast rotating blue stragglers (with rotational velocities larger than 40 km/s) increases for decreasing central density of the host system. This trend suggests that fast spinning blue stragglers prefer low-density environments and promises to open an unexplored route towards understanding the evolutionary processes of these stars. Since large rotation rates are expected in the early stages of both formation channels, our results provide direct evidence for recent blue straggler formation activity in low-density environments and put strong constraints on the timescale of the collisional blue straggler slow-down processes.
Clinical efficacy and biomarker analysis of dual PD-1/CTLA-4 blockade in recurrent/metastatic EBV-associated nasopharyngeal carcinoma
Authors: Lim Darren Wan-Teck , Kao Hsiang-Fong , Suteja Lisda , Li Constance H. , Quah Hong Sheng , Tan Daniel Shao-Weng , Tan Sze-Huey , Tan Eng-Huat , Tan Wan-Ling , Lee Justina Nadia , Wee Felicia Yu-Ting , Jain Amit , Goh Boon-Cher , Chua Melvin L. K. , Liao Bin-Chi , Ng Quan Sing , Hong Ruey-Long , Ang Mei-Kim , Yeong Joe Poh-Sheng , Iyer N. Gopalakrishna 
Published: May 2023

AbstractSingle-agent checkpoint inhibitor (CPI) activity in Epstein-Barr Virus (EBV) related nasopharyngeal carcinoma (NPC) is limited. Dual CPI shows increased activity in solid cancers. In this single-arm phase II trial (NCT03097939), 40 patients with recurrent/metastatic EBV-positive NPC who failed prior chemotherapy receive nivolumab 3 mg/kg every 2 weeks and ipilimumab 1 mg/kg every 6 weeks. Primary outcome of best overall response rate (BOR) and secondary outcomes (progression-free survival [PFS], clinical benefit rate, adverse events, duration of response, time to progression, overall survival [OS]) are reported. The BOR is 38% with median PFS and OS of 5.3 and 19.5 months, respectively. This regimen is well-tolerated and treatment-related adverse events requiring discontinuation are low. Biomarker analysis shows no correlation of outcomes to PD-L1 expression or tumor mutation burden. While the BOR does not meet pre-planned estimates, patients with low plasma EBV-DNA titre (<7800 IU/ml) trend to better response and PFS. Deep immunophenotyping of pre- and on-treatment tumor biopsies demonstrate early activation of the adaptive immune response, with T-cell cytotoxicity seen in responders prior to any clinically evident response. Immune-subpopulation profiling also identifies specific PD-1 and CTLA-4 expressing CD8 subpopulations that predict for response to combined immune checkpoint blockade in NPC.
Emergence of ferroelectricity in a nonferroelectric monolayer
Authors: Li Wenhui , Zhang Xuanlin , Yang Jia , Zhou Song , Song Chuangye , Cheng Peng , Zhang Yi-Qi , Feng Baojie , Wang Zhenxing , Lu Yunhao , Wu Kehui , Chen Lan 
Published: May 2023

AbstractFerroelectricity in ultrathin two-dimensional (2D) materials has attracted broad interest due to potential applications in nonvolatile memory, nanoelectronics and optoelectronics. However, ferroelectricity is barely explored in materials with native centro or mirror symmetry, especially in the 2D limit. Here, we report the first experimental realization of room-temperature ferroelectricity in van der Waals layered GaSe down to monolayer with mirror symmetric structures, which exhibits strong intercorrelated out-of-plane and in-plane electric polarization. The origin of ferroelectricity in GaSe comes from intralayer sliding of the Se atomic sublayers, which breaks the local structural mirror symmetry and forms dipole moment alignment. Ferroelectric switching is demonstrated in nano devices fabricated with GaSe nanoflakes, which exhibit exotic nonvolatile memory behavior with a high channel current on/off ratio. Our work reveals that intralayer sliding is a new approach to generate ferroelectricity within mirror symmetric monolayer, and offers great opportunity for novel nonvolatile memory devices and optoelectronics applications.
Interfacial interaction and intense interfacial ultraviolet light emission at an incoherent interface
Authors: Yan Xuexi , Jiang Yixiao , Jin Qianqian , Yao Tingting , Wang Weizhen , Tao Ang , Gao Chunyang , Li Xiang , Chen Chunlin , Ye Hengqiang , Ma Xiu-Liang 
Published: May 2023

AbstractIncoherent interfaces with large mismatches usually exhibit very weak interfacial interactions so that they rarely generate intriguing interfacial properties. Here we demonstrate unexpected strong interfacial interactions at the incoherent AlN/Al2O3 (0001) interface with a large mismatch by combining transmission electron microscopy, first-principles calculations, and cathodoluminescence spectroscopy. It is revealed that strong interfacial interactions have significantly tailored the interfacial atomic structure and electronic properties. Misfit dislocation networks and stacking faults are formed at this interface, which is rarely observed at other incoherent interfaces. The band gap of the interface reduces significantly to ~ 3.9 eV due to the competition between the elongated Al-N and Al-O bonds across the interface. Thus this incoherent interface can generate a very strong interfacial ultraviolet light emission. Our findings suggest that incoherent interfaces can exhibit strong interfacial interactions and unique interfacial properties, thereby opening an avenue for the development of related heterojunction materials and devices.
Prior math achievement and inventive production predict learning from productive failure
Authors: Kapur Manu , Saba Janan , Roll Ido 
Published: May 2023

AbstractA frequent concern about constructivist instruction is that it works well, mainly for students with higher domain knowledge. We present findings from a set of two quasi-experimental pretest-intervention-posttest studies investigating the relationship between prior math achievement and learning in the context of a specific type of constructivist instruction, Productive Failure. Students from two Singapore public schools with significantly different prior math achievement profiles were asked to design solutions to complex problems prior to receiving instruction on the targeted concepts. Process results revealed that students who were significantly dissimilar in prior math achievement seemed to be strikingly similar in terms of their inventive production, that is, the variety of solutions they were able to design. Interestingly, it was inventive production that had a stronger association with learning from PF than pre-existing differences in math achievement. These findings, consistent across both topics, demonstrate the value of engaging students in opportunities for inventive production while learning math, regardless of prior math achievement.
Low-pressure-driven special wettable graphene oxide-based membrane for efficient separation of water-in-oil emulsions
Authors: Baig Nadeem , Abdulazeez Ismail , Aljundi Isam H. 
Published: May 2023

AbstractOil and water separation is a significant challenge due to the rapid discharge of oily wastewater. Special wettable membranes have received substantial consideration in emulsified oil/water separation. Here, a superhydrophobic octadecyl-functionalized crosslinked graphene-oxide-grafted ceramic membrane (R18-CLGO-N-CM) was designed to separate water-in-oil emulsions. The selective layer of the ceramic membrane was evaluated using molecular dynamics simulation studies to understand its mechanism and separation capabilities. The underwater oil contact angle on the surface of the R18-CLGO-N-CM was dramatically reduced, from 141.3° ± 1.5° to 0°, and the water contact angle in air increased from 0° to 152.8° ± 0.6°, after functionalization. High hexane permeability was observed in the range of 294 to 311 Lm−2 h−1. The octadecyl-functionalized crosslinked graphene oxide acts as an excellent separating layer to selectively allow oil passage with a separation efficiency of ~99% for water-in-oil emulsion. The designed membranes show excellent antifouling behavior while dealing with water-in-heavy oil emulsions. The surface of the functionalized membrane was restored with a flux recovery ratio of 98.5% by simply treating the surface with dichloromethane while separating the water-in-light oil emulsions. This work shows that the rational functionalization and grafting of 2D materials on the membrane surface can significantly enhance the antifouling characteristics and the separation performance of the membranes.