bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk Factors for Hospital-Based Surgical Site Infections
Authors: Harikumar Vishnu , Anvery Noor , Haq Misha , Christensen Rachel E. , Ahmed Areeba , Koza Eric , Ma Melissa , Shi Victoria , Dirr McKenzie A. , Worley Brandon , Brieva Joaquin C. , Yoo Simon S. , Alam Murad 
Published: September 2023

Abstract
Background: Surgical site infections (SSIs) contribute to morbidity and are costly to the healthcare system.
Objective: To identify factors associated with SSIs.
Methods: Case-control study analyzing the Nationwide Readmission Database (NRD).
Results: We identified 45,445 SSIs. Infection rates were higher in those who were obese (BMI ≥ 30) (OR: 1.39, 95% CI: 1.28-1.51); tobacco users (OR: 1.08, 95% CI: 1.02-1.15); diagnosed with diabetes (OR: 1.16, 95% CI: 1.10-1.22); with Elixhauser Comorbidity Index ≥2 (OR: 1.14, 95% CI: 1.09-1.20), admitted to hospital for 4-6 days (OR: 1.35, 95% CI: 1.29-1.42); in medium size hospital (OR: 1.15, 95% CI: 1.05-1.26); or large-size hospital (OR: 1.43, 95% CI: 1.31-1.56). In contrast, patients who were 60-79 years old (OR: 0.78, 95% CI: 0.73-0.84); 80 years or older (OR: 0.66, 95% CI: 0.59-0.73); female (OR: 0.95, 95% CI: 0.91-0.99); underweight (BMI < 18.5) (OR: 0.14, 95% CI: 0.03-0.59); in a non-metropolitan hospital (OR: 0.83, 95% CI: 0.75-0.91); self-pay (OR: 0.82, 95% CI: 0.74-0.91); or covered by Medicare (OR: 0.86, 95% CI: 0.80-0.91) had lower odds.
Limitations: Initial data entry to NRD is susceptible to human error.
Conclusions: Patients who are obese, use tobacco, have multiple comorbidities, and have long hospital stays in medium-to-large size hospitals are at risk of SSIs. Conversely, odds of SSIs are
lower in females, age ≥ 60, BMI < 18.5, self-pay or Medicare (versus private insurance), or at smaller hospitals. Understanding factors associated with SSIs may help surgeons anticipate complications.
[2+2] photocyclized Push-Pull Type Quaternary Cyclobutane: Synthesis, Crystal Structure, Spectroscopy and Biomedical Applications
Authors: Ji Zhouqun , Yang Ting , Su Jingkang , Tang Wei , Gu Tingting , Xu Haijun , Liang Xu 
Published: September 2023

Abstract
Herein, a push-pull type stilbene compound and its [2 + 2] photocyclized cyclobutane derivative were synthesized and isolated. The structure characterizations were performed by mass, NMR, crystal structure, and TG-DSC analysis. In addition, the electronic structures and structure-property relationships of the molecules have been analyzed by comparing their redox and optical properties. Considering cyano-contained cyclobutane is a highly active organic molecule that can be widely applied in various fields, the Interactions with ctDNA and antitumor behavior of these synthetic compounds were also evaluated.
Forecasting of COVID- 19 cases using Statistical Models and Ontology-based Semantic Modelling: A real time data analytics approach
Authors: TIWARI SADHANA , CHANDRA RITESH , AGARWAL SONALI 
Published: September 2023

Abstract
SARS-COV-19 is the most prominent issue which many countries face today. The frequent changes in infections, recovered and deaths represents the dynamic nature of this pandemic. It is very crucial to predict the spreading rate of this virus for accurate decision making against fighting with the situation of getting infected through the virus, tracking and controlling the virus transmission in the community. We develop a prediction model using statistical time series models such as SARIMA and FBProphet to monitor the daily active, recovered and death cases of COVID-19 accurately. Then with the help of various details across each individual patient (like height, weight, gender etc.), we designed a set of rules using Semantic Web Rule Language and some mathematical models for dealing with COVID-19 infected cases on an individual basis. After combining all the models, a COVID-19 Ontology is developed and performs various queries using SPARQL query on designed Ontology which accumulate the risk factors, provide appropriate diagnosis, precautions and preventive suggestions for COVID Patients. After comparing the performance of SARIMA and FBProphet, it is observed that the SARIMA model performs better in forecasting of COVID cases. On individual basis COVID case prediction, approx. 497 individual samples have been tested and classified into five different levels of COVID classes such as Having COVID, No COVID, High Risk COVID case, Medium to High Risk case, and Control needed case.
Infrared stereo camera matching portable navigation reproduces accurate acetabular cup placement during total hip arthroplasty: A matched cohort study
Authors: Hayashi Shinya , Tachibana Shotaro , Kuroda Yuichi , Nakano Naoki , Matsumoto Tomoyuki , Kamenaga Tomoyuki , Tsubosaka Masanori , Kuroda Ryosuke 
Published: September 2023

Abstract
Background
Positioning of the acetabular cup during total hip arthroplasty (THA) is important for early and long-term outcomes; however, accurate cup positioning is difficult even for experienced surgeons. This study compared the accuracy of an infrared stereo camera-matching portable navigation system for cup positioning during THA in the lateral decubitus position.
Methods
This retrospective cohort study analyzed data from 104 THA patients who underwent surgery using either infrared stereo camera-matching portable navigation (n = 40) or non-navigation control (n = 64). Patients underwent THA via the anterolateral approach in the lateral decubitus position using a portable navigation system. Patient characteristics including age, body mass index, sex, treated side, target inclination, and target anteversion were adjusted by propensity score matching. Subsequently, we assessed navigation records for intraoperative cup angles, postoperative cup angles measured on CT images, cup angle measurement errors, and other clinical parameters.
Results
The mean absolute difference in radiographic anteversion between patients with use of navigation and non-navigation was smaller after propensity score matching (3.4 ± 3.1° vs. 5.6 ± 3.0°, p = 0.047). Navigation error (absolute difference in anteversion between postoperative CT and navigation records of > 5°) was significantly associated with posterior pelvic tilt in the navigation group (OR, 1.27; p = 0.030, 95% CI, 1.02–1.57).
Conclusions
Infrared stereo camera matching portable navigation provides clinically comparable precision and accuracy to determine the orientation of cup placement compared to non-navigation during THA in the lateral decubitus position. Clinicians should consider the use of this navigation system in patients with posterior pelvic tilt during THA.
A class of estimators for finite population mean of a sensitive variable using Optional Randomized Response Technique(ORRT) Models
Authors: Kumar Sunil , Singh Housila P , Rani Chanda , Gupta Rahul 
Published: September 2023

Abstract
Due to the sensitivity of questions, the surveyor finds difficult to record correct responses from respondent,which further increase the non-sampling errors. In this paper, we addresses the social desirability bias, non-response and measurement error simultaneously for the estimation of population mean of sensitive variable under the setup of Optional Randomized Response Technique Models. The properties of the suggested class of estimators have been studied and efficiency conditions have been obtained by comparing it with other existing estima-tors. Theoretical findings are supported by a empirical study through simulation models and shows significant results.
Optimizing malaria vector control: A systematic review and mathematical modelling study to identify desirable characteristics of novel tools in different settings
Authors: Wang Yuqian , Chitnis Nakul , Fairbanks Emma 
Published: September 2023

Abstract
Background: In the Greater Mekong Subregion (GMS), situated within Southeast Asia, multidrug-resistant malaria and insecticide resistance have been found, threatening malaria control and elimination. New vector-control tools targeting mosquitoes that bite outside, bite during the daytime, and are resistant to insecticide are needed. The potential of tools likely depends on their modes of action and the bionomics of the local vectors. Previously, vector-control tool selection has been supported by sensitivity analysis of vectorial capacity.
Methods: In this paper, we conducted systematic literature research to generate a bionomic dataset of the main malaria vectors in the GMS, including human blood index (HBI), parity proportion (rate), sac proportion (rate), and the resting period duration. We then used descriptive statistics and inferential statistics to analyze these bionomics. Finally, we performed global sensitivity analyses, Latin hypercube sampling-partial rank correlation coefficients (LHS-PRCC), and Sobol’s method to assess the influence of bionomic and intervention parameters on the relative change of vectorial capacity and intervention effectiveness.
Results: Our review shows that the An. minimus complex, An. sinensis, An. maculatus group, and An. sundaicus complex displays an opportunistic blood-feeding behavior, while An. dirus complex is more anthropophilic. Multivariate regression analysis shows that parity proportion is affected by environmental, climatic, and mosquito sampling factors. The resting duration is 2--3 days in hot rainy seasons and 4--6 days in a cool dry seasons. Global sensitivity analysis demonstrated that HBI and parity proportion are the most influential bionomic parameters, followed by the resting period duration. In a low HBI setting, preprandial killing, disarming, and repelling have similar impacts on model output, and are more influential than postprandial killing. However, preprandial killing has the most decisive impact in a high HBI/parity proportion setting.
Conclusions: HBI, parity proportion, sac proportion, and the resting period duration of the main malaria vectors vary in the GMS, depending on biological, environmental, or measurement differences. Although in general, preprandial killing has the largest community-level effect on reducing transmission, in low HBI settings other modes of action, such as repellency and disarming, can be effective.
Estimating the life-history parameters of the white prawn, Palaemon longirostris (Crustacea: Palaemonidae), in a temperate European estuary
Authors: de Carvalho-Souza Gustavo F. , Cuesta Jose A. , González-Ortegón Enrique 
Published: September 2023

Abstract

Life history parameters are indicators of stock structure and for the dynamics of biological populations. In this work, we examine multiple life-history parameters (size distribution, growth, mortality, and longevity) of Palaemon longirostris H. Milne Edwards, 1837 inhabiting the estuarine temperate waters of the Guadalquivir estuary through size-frequency distribution data obtained from June 1997 to May 1999. Sexual dimorphism in size was evident, as females displayed a larger body size than males. The carapace length-weight relationship indicated a negative allometric growth pattern in both sexes. Additionally, the growth performance index indicated a higher value for females (Φ = 2.50) compared to males (Φ = 2.33). The recruitment pattern analysis of P. longirostris indicated that females experienced a greater recruitment rate from March to August, while males exhibited a higher recruitment rate between April and July. Our study found that natural and fishing mortality rates were similar among male P. longirostris, whereas fishing mortality had a smaller effect on the overall mortality of females. The exploitation rates for both male and female stocks were optimally balanced. These findings, more than increasing our understanding of the life-history strategies of P. longirostris, garner data used to understand the ongoing effects of climate change upon this species.
Synthesis, Cytotoxic Potential, and Molecular Docking Studies of
Ortho-carboxamidostilbene Analogs
Authors: Mohamad Norhadi , Muhamad Musthahimah , Tan Aik Sian , Kamal Nik Nur Syazni Nik Mohd. , Che Omar Mohammad Tasyriq , Abu Bakar Mohamad Hafizi , Supratman Unang , Nafiah Mohd. Azlan , Nurul Azmi Mohamad 
Published: September 2023

Abstract:
A total of eleven ortho-carboxamidostilbene derivatives were synthesized through Heck coupling with a
different type of amide derivatives. These compounds were characterized by FTIR, 1D- and 2D-NMR as well as
mass spectroscopy analysis (HRESIMS). The synthesized compounds were tested for their cytotoxic potential
against four human cancer cell lines (MCF-7, MDA-MB-231, MCF-7/TAMR-1, and A549), as well as two human
normal cell lines (MCF-10A and BEAS-2B) using tamoxifen and cisplatin as a positive control. The active compound
has proceeded with molecular docking on the colchicine binding site of tubulin protein using AutoDock Vina
and Biovia Discovery Studio. Compounds 6a, 6d-6k exhibited selective cytotoxic activity against A549 cells
rather than breast cancer cell lines. Compounds 6d, 6f, and 6g showed moderate cytotoxicity to A549 cells after 72
hours, with IC50 values of 10.4 μM, 6.47 μM, and 8.99 μM, respectively. Interestingly, these compounds had a
high selective index (SI) value against A549 lung cancer cells, ranging from 8.87 to 15.4 μM. Molecular docking
studies for compounds 6d, 6f, and 6g on the colchicine binding site of tubulin protein, α- and β-subunits were done
to comprehend and research ligand-receptor interactions.
NMR and FT-IR Investigation Study and Topological Analysis of Various
Conformations of 2,5-dimethyl-2,5-dihydroxyl-1,4-dithian using Density Functional
Theory Method
Authors: Danaie Elmira , Masoudi Shiva , Masnabadi Nasrin 
Published: September 2023

Abstract:
1,4-dithian-2,5-dihydroxyl is the major source for the synthesis of sulfur-containing heterocyclic compounds such as thiophene and 1,3-thiazole derivatives, which these compounds are widely used in pharmaceuticals
and agricultural industries. Sulfur-containing heterocycles, such as 2-aminothiophene, thiazolidine, oxothiazolidine,
and thiazoles, can be comprehensively synthesized from dimerization of the derivatives of 1,4-dithian-2,5-
dihydroxyl. FT-IR and NMR spectra of axial and equatorial conformations of 2,5-dimethyl-2,5-dihydroxyl-1,4-
dithian compound were investigated by density functional theory (DFT) using B3LYP/6-311++G** and M06-
2X/aug-cc-pVDZ computational methods. The topological properties of the electron charge density were calculated
by the quantum theory of atoms in molecules (QTAIM) and non-covalent interactions/reduced electron density
gradient (NCI-RDG) theoretical methods. The obtained results of the analyses were also discussed in more detail.
The results showed that the steric interactions are more prominent than the van der Waals interactions, and in both
conformations, steric interactions are included in the middle of the 1,4-dithian ring and there is hydrogen bonding
between hydroxyl groups and 1,4-dithian ring structure heteroatoms in the axial conformation while this interaction
is not observed in the case of equatorial conformation. The presence of these interactions was confirmed using
NBO analysis.
Which can Predict the Outcome of Antidepressants: Metabolic Genes or Pharmacodynamic
Genes?
Authors: Zheng Nan , Niu Mengxi , Zang Yannan , Zhuang Hongyan , Jia Fei , Bao Shuang , Liu Shanshan 
Published: September 2023

Abstract:
Drug therapy is the primary modality for depression; however, its outcome is often unpredictable, ranging
from beneficial effects to serious adverse effects. Genetic variations in drug metabolizing enzymes and pharmacodynamic
molecules are responsible for a considerable proportion of interindividual differences in the effectiveness and
toxicity of antidepressants. For the improvement in the use of antidepressants, the focus is mainly on personalized
treatment emphasizing interindividual differences in genes. This study provides a comprehensive review of the literature
on the clinical applications of pharmacogenomics for antidepressant therapy. The polymorphisms of metabolizing
enzymes (CYP2D6, CYP2C19, and others) governing the pharmacokinetic behavior of drugs are potential predictors
of side effects or treatment failure with medications and there are good pharmacogenetic clinical recommendations
for a wide selection of psychopharmacological agents based on functional diplotypes of CYP2C19 and
CYP2D6. The relationship between pharmacodynamic genes, including FKBP5, SLC6A4, BDNF, ABCB1, HTR1A,
and HTR2A, and clinical outcomes varies in different races. Receptors that are currently used as drug targets for
antidepressant drugs are evolutionarily conserved to a higher extent than genes encoding drug metabolism, and the
actionability of pharmacodynamic-related genotyping is currently still questionable. The limited availability of largescale,
long-term clinical studies on different races and medications currently impedes the implementation of pharmacogenomics
in antidepressant treatment. The use of pharmacokinetic and pharmacodynamic modeling, and therapeutic
drug monitoring combined with genetic, somatic, dietary, and environmental factors represents a promising
avenue for improving the precision and effectiveness of antidepressant therapy.
Antimicrobial and Cytotoxic Naphthoquinones from Microbial Origin: An
Updated Review
Authors: Kashi Marziyeh Esmaeilzadeh , Ghorbani Mahdiyeh , Badibostan Hasan , Seidel Veronique , Hosseini Seyed Hamzeh , Asili Javad , Shakeri Abolfazl , Sahebkar Amirhossein 
Published: September 2023

Abstract:
Naphthoquinones (NQs) are small molecules bearing two carbonyl groups. They have
been the subject of much research due to their significant biological activities such as antiproliferative,
antimicrobial, anti-inflammatory, antioxidant, and antimalarial effects. NQs are produced
mainly by bacteria, fungi and higher plants. Among them, microorganisms are a treasure of NQs
with diverse skeletons and pharmacological properties. The purpose of the present study is to provide
a comprehensive update on the structural diversity and biological activities of 91 microbial
naphthoquinones isolated from 2015 to 2022, with a special focus on antimicrobial and cytotoxic
activities. During this period, potent cytotoxic NQs such as naphthablin B (46) and hygrocin C (30)
against HeLa (IC50=0.23 μg/ml) and MDA-MB-431 (IC50=0.5 μg/ml) cell lines was reported, respectively.
In addition, rubromycin CA1 (39), exhibited strong antibacterial activity against Staphylococcus
aureus (MIC of 0.2 μg/ml). As importance bioactive compounds, NQs may open new
horizon for treatment of cancer and drug resistant bacteria. As such, it is hoped that this review article
may stimulates further research into the isolation of further NQs from microbial, and other
sources as well as the screening of such compounds for biological activity and beneficial uses.
Comprehensive Review on Recent Strategies for Management of Prostate
Cancer: Therapeutic Targets and SAR
Authors: Chaudhary Manish , Kumar Shubham , Kaur Paranjeet , Sahu Sanjeev Kumar , Mittal Amit 
Published: September 2023

Abstract:
Prostate cancer is a disease that is affecting a large population worldwide. Androgen deprivation
therapy (ADT) has become a foundation for the treatment of advanced prostate cancer, as used
in most clinical settings from neo-adjuvant to metastatic stage. In spite of the success of ADT in managing
the disease in the majority of men, hormonal manipulation fails eventually. New molecules are
developed for patients with various hormone-refractory diseases. Advancements in molecular oncology
have increased understanding of numerous cellular mechanisms which control cell death in the
prostate and these insights can lead to the development of more efficacious and tolerable therapies for
carcinoma of the prostate. This review is focused on numerous therapies that might be a boon for
prostate therapy like signaling inhibitors, vaccines, and inhibitors of androgen receptors. Along with
these, various bioactive molecules and their derivatives are highlighted, which act as potential antiprostate
cancer agents. This article also emphasized the recent advances in the field of medicinal
chemistry of prostate cancer agents.
The Common Denominators of Parkinson’s Disease Pathogenesis and
Methamphetamine Abuse
Authors: Vincent Bruno , Shukla Mayuri 
Published: September 2023

:
The pervasiveness and mortality associated with methamphetamine abuse have doubled
during the past decade, suggesting a possible worldwide substance use crisis. Epitomizing the pathophysiology
and toxicology of methamphetamine abuse proclaims severe signs and symptoms of neurotoxic
and neurobehavioral manifestations in both humans and animals. Most importantly, chronic use
of this drug enhances the probability of developing neurodegenerative diseases manifolds. Parkinson's
disease is one such neurological disorder, which significantly and evidently not only shares a number
of toxic pathogenic mechanisms induced by methamphetamine exposure but is also interlinked both
structurally and genetically. Methamphetamine-induced neurodegeneration involves altered dopamine
homeostasis that promotes the aggregation of α-synuclein protofibrils in the dopaminergic neurons and
drives these neurons to make them more vulnerable to degeneration, as recognized in Parkinson’s disease.
Moreover, the pathologic mechanisms such as mitochondrial dysfunction, oxidative stress, neuroinflammation
and decreased neurogenesis detected in methamphetamine abusers dramatically resemble
to what is observed in Parkinson’s disease cases. Therefore, the present review comprehensively
cumulates a holistic illustration of various genetic and molecular mechanisms putting across the notion
of how methamphetamine administration and intoxication might lead to Parkinson’s disease-like
pathology and Parkinsonism.
A Preliminary Study of Brain Functional Magnetic Resonance Imaging in Text
Reading and Comprehension
Authors: Xie Qi , Chen Huixian , He Wenjuan , Tan Zhilin , Wang Yajie , Liao Yanhui 
Published: September 2023

Background:
Few studies have focused on the changes in human brain function activities caused by reading Chinese characters with different intelligibility and
whether it can reflect the understanding and cognitive ability of the human brain.

Objective:
Task-fMRI based on Chinese character reading tasks with different intelligibility was used to explore activated brain regions and their cognitive
changes.

Methods:
Volunteers were randomly recruited using advertisements. Forty volunteers were recruited based on strict inclusion and exclusion criteria, and 40
volunteers were recruited. Brain function data of 40 healthy right-handed volunteers in fuzzy/clear Chinese reading tasks were collected using a
Siemens Skyra 3.0T magnetic resonance scanner. Data were preprocessed and statistically analyzed using the statistical software SPM12.0 to
observe the activation of the cortex and analyze its characteristics and possible changes in cognitive function.

Results:
Task-fMRI analysis: (1) The main brain regions activated in fuzzy/clear reading tasks were located in the occipital visual cortex (P < 0.001); (2) a
paired sample t-test suggested that there was a significant difference in BOLD signals in the brain regions activated by fuzzy/clear reading tasks (P
< 0.001, equiv Z = 4.25). Compared with the fuzzy reading task, the brain regions more strongly activated in the clear reading task were mainly
located in the right superior frontal gyrus and the bilateral temporal lobe. Compared with the clear reading task, the brain region that was more
strongly activated in the fuzzy reading task was mainly located in the right fusiform gyrus.

Conclusion:
Clear Chinese character information mainly activates the dorsal stream of the visual-spatial network. This reflects the information transmission of
the brain after understanding the text content and is responsible for guiding and controlling attention. Fuzzy words that cannot provide clear text
content activate the fusiform gyrus of the ventral stream of the visual-spatial network, strengthening the function of orthographic processing.