bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sleep Differentially and Profoundly Impairs Recall Memory in a Patient with Fornix Damage
Authors: Matorina Nelly , Tseng Julie , Ladyka-Wojcik Natalia , Olsen Rosanna , Mabbott Donald J. , Barense Morgan D. 
Published: August 2023

Abstract
In March 2020, C.T., a kind, bright, and friendly young woman underwent surgery for a midline tumor involving her septum pellucidum and extending down into her fornices bilaterally. Following tumor diagnosis and surgery, C.T. experienced significant memory deficits: C.T.'s family reported that she could remember things throughout the day, but when she woke up in the morning or following a nap, she would expect to be in the hospital, forgetting all the information that she had learned before sleep. The current study aimed to empirically validate C.T.'s pattern of memory loss and explore its neurological underpinnings. On two successive days, C.T. and age-matched controls watched an episode of a TV show and took a nap or stayed awake before completing a memory test. Although C.T. performed numerically worse than controls in both conditions, sleep profoundly exacerbated her memory impairment, such that she could not recall any details following a nap. This effect was replicated in a second testing session. High-resolution MRI scans showed evidence of the trans-callosal surgical approach's impact on the mid-anterior corpus callosum, indicated that C.T. had perturbed white matter particularly in the right fornix column, and demonstrated that C.T.'s hippocampal volumes did not differ from controls. These findings suggest that the fornix is important for processing episodic memories during sleep. As a key output pathway of the hippocampus, the fornix may ensure that specific memories are replayed during sleep, maintain the balance of sleep stages, or allow for the retrieval of memories following sleep.
Cognotyping by What–Where–When Retrieval Reveals the Potential Role of Temporal Memory and Its Neural Correlates in Understanding Individual Differences across Aging and Alzheimer Disease
Authors: Park Sang-Eon , Lee Jeonghyun , Park Jin-Hyuck , Hwang Maria Jieun , Lee Sang Ah 
Published: August 2023

Abstract
Despite distinct neural representation of what, where, and when information, studies of individual differences in episodic memory have neglected to test the three components separately. Here, we used a componential episodic memory task to measure cognitive profiles across a wide age range and in Alzheimer disease (AD) and to examine the role of theta oscillations in explaining performance. In Experiment 1, we tested a group of 47 young adults (age 21–30 years, 21 women) while recording their scalp EEG. A separate behavioral experiment (Experiment 2) was performed in 42 older adults (age 66–85 years, 29 women) and in a group of 16 AD patients (age 80–90 years, 12 women). In Experiment 1, K-means clustering based on behavioral data resulted in three “cognotypes” whose memory profiles showed corresponding differences in their EEG markers: What and where memory depended on frontal theta power and when memory depended on theta modulation by temporal distance between retrieved items. In Experiment 2, healthy older adults showed three cognotypes similar to those found in younger adults; moreover, AD patients had an overlapping profile with one specific cognotype, characterized by marked difficulties in when memory. These findings highlight the utility of componential episodic memory tests and cognotyping in understanding individual strengths and vulnerabilities in age-related neurocognitive decline.
Collective Human Opinions in Semantic Textual Similarity
Authors: Wang Yuxia , Tao Shimin , Xie Ning , Yang Hao , Baldwin Timothy , Verspoor Karin 
Published: August 2023

Abstract
Despite the subjective nature of semantic textual similarity (STS) and pervasive disagreements in STS annotation, existing benchmarks have used averaged human ratings as gold standard. Averaging masks the true distribution of human opinions on examples of low agreement, and prevents models from capturing the semantic vagueness that the individual ratings represent. In this work, we introduce USTS, the first Uncertainty-aware STS dataset with ∼15,000 Chinese sentence pairs and 150,000 labels, to study collective human opinions in STS. Analysis reveals that neither a scalar nor a single Gaussian fits a set of observed judgments adequately. We further show that current STS models cannot capture the variance caused by human disagreement on individual instances, but rather reflect the predictive confidence over the aggregate dataset.
An Intraseasonal Dipole Mode in Summertime Surface Air Temperature over Eurasia and Its Association with Heat Wave Occurrence
Authors: Wang Xudong , Zhang Renhe , Jin Dachao , Zhang Yu 
Published: August 2023

Abstract
A strong coherence of the summer (June–August) surface air temperature (SAT) anomalies exists over eastern Eurasia (EE) and central Eurasia (CE) in association with a remarkable intraseasonal (10–90-day) variability. The intraseasonal SAT over Eurasia shows a negative correlation between EE and CE, which is closely related to an intraseasonal wave train at the upper troposphere over the mid–high latitudes of Eurasia. The wave train propagates eastward and results in the intraseasonal variation of SAT in a seesaw pattern. The column-integrated temperature budget suggests that both the horizontal and vertical advection are important for the intraseasonal SAT dipole. More specifically, the climatological westerly, intraseasonal meridional wind anomaly, and the anomalous vertical motion play dominant roles in perturbing temperature over the CE and EE regions, while the diabatic heating is a negative feedback. The propagation of the Rossby wave train in the upper troposphere helps to maintain the circulation anomalies associated with the SAT seesaw. The leading modes of meridional wind anomalies at 200 hPa over the Eurasian high latitudes resemble the intraseasonal wave train, indicating that the wave train associated with the SAT seesaw is an atmospheric intrinsic mode over the mid–high latitudes. This study also investigates the impact of the intraseasonal SAT seesaw on regional heat wave events. It is suggested that the intraseasonal SAT seesaw has a major influence on the variability of heat wave events over both EE and CE, which may provide great implications for regional subseasonal forecasts of extreme weather events.
Development and Validation of a Short-Form Version of the Western Ontario Shoulder Instability Scale (Short-WOSI)
Authors: Jacobs Cale A. , Ortiz Shannon F. ,   MOON Shoulder Group, Baumgarten Keith M. , Bishop Julie Y. , Bollier Matthew J. , Bravman Jonathan T. , Brophy Robert H. , Cvetanovich Gregory L. , Feeley Brian T. , Frank Rachel M. , Jones Grant L. , Kuhn John E. , Lansdown Drew A. , Ma C. Benjamin , Mair Scott D. , Marx Robert G. , McCarty Eric C. , Seidl Adam J. , Wright Rick W. , Zhang Alan L. , Wolf Brian R. , Hettrich Carolyn M. 
Published: August 2023

Background: Patient-reported outcome measures (PROMs) have transitioned from primarily being used as research instruments to becoming increasingly used in the clinical setting to assess recovery and inform shared decision-making. However, there is a need to develop validated short-form PROM instruments to decrease patient burden and ease incorporation into clinical practice. Purpose: To assess the validity and responsiveness of a shortened version of the Western Ontario Shoulder Instability Index (Short-WOSI) when compared with the full WOSI and other shoulder-related PROM instruments. Study Design: Cohort study (diagnosis); Level of evidence, 2. Methods: This study was a secondary analysis of data collected as part of an institutional review board–approved, multicenter cohort of 1160 patients undergoing surgical stabilization for shoulder instability. The following PROMs were captured preoperatively and 2 years after surgery: WOSI, American Shoulder and Elbow Surgeons (ASES) score, the Single Assessment Numeric Evaluation (SANE), and 36-Item Health Survey (RAND-36). The cohort was split into 2 data sets: a training set to be used in the development of the Short-WOSI (n = 580) and a test set to be used to assess the validity and responsiveness of the Short-WOSI relative to the full WOSI, ASES, SANE, and RAND-36. Results: The Short-WOSI demonstrated excellent internal consistency before surgery (Cronbach α = .83) and excellent internal consistency at the 2-year follow-up (Cronbach α = .93). The baseline, 2-year, and pre- to postoperative changes in Short-WOSI and WOSI were closely correlated ( r > 0.90), with both demonstrating large effect sizes (Short-WOSI = 1.92, WOSI = 1.81). Neither the Short-WOSI nor the WOSI correlated well with the other PROM instruments before ( r = 0.21-0.33) or after ( r = 0.25-0.38) surgery. The Short-WOSI, WOSI, and SANE scores were more responsive than ASES and RAND-36 scores. Conclusion: The 7-item Short-WOSI demonstrated excellent internal consistency and a lack of floor or ceiling effects. The Short-WOSI demonstrated excellent cross-sectional and longitudinal construct validity and was similarly responsive over time as the full WOSI. Neither the Short-WOSI nor WOSI correlated with more general shoulder PROMs, underscoring the advantage of using instability-specific instruments for this population.
Evaluating Phonemic Awareness and Orthographic Mapping With the Woodcock–Johnson IV
Authors: Parkin Jason R. , Hajovsky Daniel B. , Alfonso Vincent C. 
Published: August 2023

Although phonemic awareness is an essential skill in learning to decode written words, practitioners may question which phonemic awareness tasks best operationalize their relationship with orthographic mapping, the process that converts a decoded word into one instantly recognized on sight. Tests from the Woodcock– Johnson IV were used to evaluate the effects of phonemic awareness tasks and vocabulary on measures of pseudoword decoding, word reading, and spelling in three age groups (ages 6 to 8, 9 to 13, and 14 to 19 years) within the WJ IV normative sample ( N = 4082). Results from path analysis indicated the effects of phonemic awareness tasks and vocabulary varied depending on age and reading task type with mixed results based on theoretical expectations. Results from the 9 to 13 age group appeared closest to conforming to hypotheses. We discuss implications of measuring phonemic awareness, reading, and spelling in the context of comprehensive psychoeducational assessment.
Surgical High Dependency Admissions after Elective Laparoscopic Colorectal Resections: Is It Truly Necessary?
Authors: Tan Jarrod K.H. , Koh Wei-Ling , Peh Cherie Hui , Lee Ailica W.X. , Lau Jerrald , Chee Corissa , Tan Ker-Kan 
Published: August 2023

Background Surgical high dependency (SHD) allows for intermediate care provision between general ward (GW) and intensive care unit (ICU) for surgical patients but no universally accepted admission criteria exists. Unnecessary SHD admissions should be minimized to limit resource wastage and maintain spare critical care capacity. This study evaluates the utility of SHD admissions following elective laparoscopic colectomy by comparing post-operative outcomes and interventions performed between SHD and GW patients. Methodology A retrospective review of all colorectal cancer patients who underwent elective laparoscopic colectomy in our institution between January 2019 and December 2021 was conducted. Patients converted to open surgery or admitted to IC post-operatively were excluded. Peri-operative parameters and outcomes between patients admitted to GW and SHD post-operatively were evaluated. Results The cohort comprised 393 patients. There were 153 patients (38.93%) who required SHD admission. SHD patients had higher American Society of Anesthesiology (ASA) scores, body mass index, age and intra-operative blood loss. Majority of post-operative morbidity were minor (Clavien–Dindo II or lower) in both groups and the interventions required were safely instituted in both SHD and GW. None of the patients in the cohort required inotropic or ventilatory support in the SHD. Conclusions GW patients were “healthier” but post-operative morbidity and interventions required were similar to the SHD group. Nonetheless, treatment delays, absence of continuous monitoring, and decreased nurse-to-patient ratio may be significant for patients with limited physiological reserves. Further studies should evaluate safety and cost-effectiveness of managing high risk surgical patients in GW using continuous remote vital signs monitoring.
Medical Responsibility in the Libyan Law
Authors: Benomran Fawzi A. 
Published: August 2023

In Libya medical responsibility has always been a very delicate issue particularly in relation to medical negligence dealt with under common law. Lawyers are aware that certain matters are unique to the medical profession and do not apply to legal situations involving other professions. A law on medical responsibility was enacted in 1986 in Libya. This Act was named “Act on Medical Responsibility” or Act 17 for the year 1986”. It consists of 38 Articles and deals with the subject of medical responsibility according to the Libyan Law. Certain provisions concerning ethical issues are made according to Islamic rules and tradition. In this paper, an attempt has been made to translate the Act into English. The author has tried to convey meanings in a way that English speaking persons would find easy to understand.
lncRNA PCA3 Suppressed Carotid Artery Stenosis and Vascular Smooth Muscle Cell Function via Negatively Modulating the miR-124-3p/ITGB1 Axis
Authors: Li Guosheng , Chen Qiang 
Published: August 2023

Background & objectives Due to the hidden pathogen, carotid artery stenosis (CAS) always occurred at an advanced stage leading to serious sequelae and even deaths. The significance of long noncoding RNA (lncRNA) prostate cancer antigen 3 (PCA3) in CAS incidence and progression were evaluated aiming to explore a potential target for its therapy. Materials and methods Serum samples were collected from 83 asymptomatic CAS patients and 52 healthy individuals and PCA3 was compared using polymerase chain reaction (PCR). The PCA3 levels were compared between stable and unstable plaque in CAS patients. The effect of PCA3 on vascular smooth muscle cells (VSMCs) proliferation and motility was assessed by CCK8 and transwell assay. Results PCA3 was downregulated in CAS patients and their unstable plaque tissues compared with healthy individuals and stable plaque, respectively. Reduced PCA3 could discriminate CAS patients with relatively high sensitivity and specificity and were associated with higher total cholesterol level and stenosis degree, unstable plaque, and complications. PCA3 downregulation predicted the adverse outcomes of CAS patients. In VSMCs, overexpressing PCA3 significantly suppressed cell proliferation, migration, and invasion, which was alleviated by miR-124-3p/ITGB1 axis. Conclusion PCA3 served as a biomarker of CAS and regulates the function of VSMCs through sponging miR-124-3p/ITGB1 and indirectly influence the stability of plaque.
The Mastoid Skin Graft: A Fast, Efficient Donor Site for Auricle Reconstruction After Mohs Surgery
Authors: Berl Ariel , Shir-az Ofir , Mann Din , Weiss Eitam , Bilal Biader Samih , Shalom Avshalom 
Published: August 2023

Background Mohs micrographic surgery has been considered the gold standard for treating nonmelanoma skin cancers. Approximately 8% to 10% of skin cancers requiring Mohs surgery occur on the auricle. Skin grafts can be used to achieve optimal functional and cosmetic results. Objectives To describe a skin graft technique using the mastoid area as a donor site for auricular reconstruction following Mohs micrographic surgery, to achieve optimal esthetic results in functionally important areas. Methods This retrospective study assessed the outcomes of patients who underwent MMS in an out-patient Mohs surgery clinic from 2010 to 2021. All patients had MMS of the auricle with reconstruction using a split thickness skin graft harvested from the mastoid area. Results A total of 154 patients were included. The average lesion diameter was 13.7 mm (range 5–30 mm), excised in an average of 1.9 rounds of MMS. Skin graft success rate was 96%. Complications included one patient with a hypertrophic scar. The cosmetic appearance of the recipient site was rated as excellent by 87.5% of patients. All patients rated the cosmetic appearance of the donor area as excellent and well-concealed. Conclusions Split thickness skin grafts harvested from the mastoid area are a quick and efficient reconstruction method for post-Mohs auricular defects.
Genome-wide Epigenetic Study of Chronic Rhinosinusitis Tissues Reveals Dysregulated Inflammatory, Immunologic and Remodeling Pathways
Authors: Brar Tripti , Baheti Saurabh , Marino Michael J. , Kita Hirohito , Lal Devyani 
Published: August 2023

Background Epigenetics studies mechanisms such as DNA methylation, histone modifications, non-coding RNAs, and alternative polyadenylation that can modify gene activity without changing the underlying DNA nucleotide base-pair structure. Because these changes are reversible, they have potential in developing novel therapeutics. Currently, seven pharmaceutical agents targeting epigenetic changes are FDA approved and commercially available for treatment of certain cancers. However, studies investigating epigenetics in chronic rhinosinusitis (CRS) have not been undertaken previously in the United States. Objectives The goal of this study was to investigate sinonasal DNA methylation patterns in CRS versus controls, to discern environmentally-induced epigenetic changes impacting CRS subjects. Methods and Results Ethmoidal samples from CRS and inferior turbinate mucosal tissue samples from controls without CRS were studied. DNA methylation was studied by Reduced Representation Bisulfite Sequencing. RADMeth® biostatistical package was used to identify differentially methylated regions (DMRs) between CRS and controls. Ingenuity Pathway analysis of DMRs was performed to identify top upstream regulators and canonical pathways. Ninety-three samples from 64 CRS subjects (36 CRSwNP; 28 CRSsNP) and 29 controls were studied. CRS and control samples differed in 13 662 CpGs sites and 1381 DMRs. Top upstream regulators identified included: 1. CRS versus controls: TGFB1, TNF, TP53, DGCR8, and beta-estradiol. 2. CRSwNP versus controls: TGFB1, CTNNB1, lipopolysaccharide, ID2, and TCF7L2. 3. CRSsNP versus controls: MYOD1, acetone, ID2, ST8SIA4, and LEPR. Conclusions Differential patterns of methylation were identified between controls and CRS, CRSwNP, and CRSsNP. Epigenetic, environmentally-induced changes related to novel, inflammatory, immunologic, and remodeling pathways appear to affect epithelial integrity, cell proliferation, homeostasis, vascular permeability, and other yet uncharacterized pathways and genes.
National Patterns in Utilization of Knee and Hip Arthroscopy: An Analysis of Racial, Ethnic, and Geographic Disparities in the United States
Authors: Amen Troy B. , Chatterjee Abhinaba , Rudisill Samuel S. , Joseph Gabriel P. , Nwachukwu Benedict U. , Ode Gabriella E. , Williams Riley J. 
Published: August 2023

Background: Racial and ethnic disparities in the field of orthopaedic surgery have been reported extensively across many subspecialties. However, these data remain relatively sparse in orthopaedic sports medicine, especially with respect to commonly performed procedures including knee and hip arthroscopy. Purpose: To assess (1) differences in utilization of knee and hip arthroscopy between White, Black, Hispanic, and Asian or Pacific Islander patients in the United States (US) and (2) how these differences vary by geographical region. Study Design: Descriptive epidemiology study. Methods: The study sample was acquired from the 2019 National Ambulatory Surgery Sample database. Racial and ethnic differences in age-standardized utilization rates of hip and knee arthroscopy were calculated using survey weights and population estimates from US census data. Poisson regression was used to model age-standardized utilization rates for hip and knee arthroscopy while controlling for several demographic and clinical variables. Results: During the study period, rates of knee arthroscopy utilization among White patients were significantly higher than those of Black, Hispanic, and Asian or Pacific Islander patients (ie, per 100,000, White: 180.5, Black: 113.2, Hispanic: 122.2, and Asian: 58.6). Disparities were even more pronounced among patients undergoing hip arthroscopy, with White patients receiving the procedure at almost 4 to 5 times higher rates (ie, per 100,000, White: 12.6, Black: 3.2, Hispanic: 2.3, Asian or Pacific Islander: 1.8). Disparities in knee and hip arthroscopy utilization between White and non-White patients varied significantly by region, with gaps in knee arthroscopy being most pronounced in the Midwest (adjusted rate ratio, 2.0 [95% CI, 1.9-2.1]) and those in hip arthroscopy being greatest in the West (adjusted rate ratio, 5.3 [95% CI, 4.9-5.6]). Conclusion: Racial and ethnic disparities in the use of knee and hip arthroscopy were found across the US, with decreased rates among Black, Hispanic, and Asian or Pacific Islander patients compared with White patients. Disparities were most pronounced in the Midwest and South and greater for hip than knee arthroscopy, possibly demonstrating emerging inequality in a rapidly growing and evolving procedure across the country.
Comparing Witness Behavior Between Violent, Property and White-Collar Crimes: Some Covariates of Reporting Decision
Authors: Shahbazov Ingilab , Balayeva Ayshem , Afandiyev Zaur , Karimov Namig 
Published: August 2023

Based on the analysis of a survey among university students, the current study investigates the correlates of witness decision-making for three types of crime: white-collar crime, violent crime, and property crime. Using hypothetical scenarios, we contribute to the literature on law enforcement-citizen cooperation and white-collar criminality by (a) exploring whether witness willingness to report differs depending on the crime, and (b) separately assessing the effects of independent variables on witness decision-making. The overall level of willingness to report across hypothetical scenarios was high. Both property crime and violent crime are more likely to be reported than white-collar offenses. Irrespective of crime type those with previous contact with the criminal justice system in the last 3 years and lower level confidence in the police effectiveness expressed a lower likelihood of reporting crimes they would witness. The level of trust in the police correlated with the likelihood of reporting violent crimes and property crimes only, while sex was associated with violent crime and white-collar crime.