bluuebunny/crossref_metadata_2025_split huggingface dataset:
<strong>Common and distinct genetic architecture of age at diagnosis of diabetes in South Indian and European populations</strong>
Authors: Srinivasan Sundararajan , Liju Samuel , Sathish Natarajan , K Siddiqui Moneeza , Mohan Anjana Ranjit , R. Pearson Ewan , S.F. Doney Alexander , Mohan Viswanathan , Radha Venkatesan , N.A Palmer Colin 
Published: June 2023

<p>OBJECTIVE</p>
<p>South Asians are diagnosed with type 2 diabetes (T2D) more than a decade earlier in life than seen in European populations. We hypothesised that studying the genomics of age of diagnosis in these populations may give insight into earlier age diagnosis of T2D among individuals of South Asian descent. </p>
<h3>RESEARCH DESIGN AND METHODS </h3>
<p>We conducted a meta-analysis of GWAS of age at diagnosis of T2D in 34,001 individuals from four independent cohorts of European and South Asian Indians. </p>
<h3>RESULTS </h3>
<p>We identified two signals near the <em>TCF7L2</em> and <em>CDKAL1</em> associated with age at the onset of T2D. The strongest genome-wide significant variants at chromosome 10q25·3 in <em>TCF7L2</em> (rs7903146; p = 2·4 ×10-12, Beta = -0·436; SE = 0·02) and chromosome 6 p22·3 in <em>CDKAL1</em> (rs9368219; p = 2·29 ×10-8; Beta = -0·053; SE=0·01) were directionally consistent across ethnic groups and present at similar frequencies, however both loci harboured additional independent signals that were only present in the South Indian Cohorts. A genome wide signal was also obtained at chromosome 10q26·12 in <em>WDR11</em> (rs3011366; p = 3.255 ×10-8; Beta = 1·44; SE=0·25) specifically in the South Indian cohorts. Heritability estimates for the age diagnosis were much stronger in South Indian compared to Europeans, and a polygenic risk score was constructed using a South Indians, which explained about 2% trait variance.</p>
<h3>CONCLUSIONS </h3>
<p>Our findings provide a better understanding of ethnic differences in the age at diagnosis and indicate the potential importance of ethnic differences in the genetic architecture underpinning T2D.</p>
<p> </p>
Analisis Pembelajaran PTM di Masa New Normal terhadap Hasil Belajar Siswa Mi Al Furqon Kelas Tiga
Authors: Diyana Fadiyah Nur , Badruli Martati  , Fajar Setiawan  
Published: June 2023

Pandemi covid-19 ini sangat berdampak bagi seluruh dunia terutama di Indonesia khususnya dari segi pendidikan. karena virus corona yang mudah sekali menyebar sehingga pemerintah memberlakukan pembelajaran di rumah melalui jaringan. Sehingga pembelajaran di sekolah mengalami berbagai problmetaika. Tujuan dari penelitian ini adalah untuk mengetahui seberapa besar pengaruh Pembelajaran Ptm Di Masa New normal Terhadap Hasil Belajar Siswa Kelas 3 MI Al Furqon Srowo Sidayu Gresik Tahun Ajaran 2021/2022. Serta untuk mengetahui apa saja kendala dan hambatan yang dirasakan guru maupun murid ketika melakukan kegiatan belajar mengajar via daring selama masa pandemic covid-19 ini. Responden adalah siswa kelas 3 MI karena mereka masih banyak yang belum menguasai penggunaan internet dan android, kemudian juga masih banyak dari mereka yang belum memiliki fasilitas gadget pribadi yang memadai. Penelitian ini menggunakan metode kualitatif dalam bentuk deskriptif dimana sumber data dan informasi utamanya diperoleh dari responden yang sudah dipilih oleh peneliti. Peneliti akan melakukan wawancara pada guru MI Al Furqon Srowo Sidayu Gresik, melakukan observasi lapangan secara langsung dan mengumpulkan dokumen dokumen penting yang mampu menunjang penelitian.
STRATEGI DAKWAH PADA MASYARAKAT PERBATASAN INDONESIA (STUDI TERHADAP DAKWAH DI DESA BADAU KECAMATAN BADAU KABUPATEN KAPUAS HULU)
Authors: Hairani Mita 
Published: June 2023

Penelitian ini dilatarbelakangi oleh berkembangnya Islam diikuti dengan berbagai aspek lainnya di Desa Badau, padahal Desa Badau berada diantara desa lain yang mayoritas penduduknya non muslim. Selain itu, belum ada penelitian tentang strategi dakwah di kawasan perbatasan Desa Badau, padahal kawasan perbatasan merupakan daerah yang rawan akan masuknya ideologi asing sehingga strategi dakwah penting diterapkgtan agar Islam dapat berdiri kokoh.
Tujuan dari penelitian ini adalah untuk mengetahui: 1) Metode yang digunakan para da’i dalam berdakwah kepada masyarakat perbatasan di Desa Badau; 2) Materi yang disampaikan para da’i dalam berdakwah kepada masyarakat perbatasan di Desa Badau; 3) Media yang digunakan para da’i dalam berdakwah kepada masyarakat perbatasan di Desa Badau; 4) Hambatan dan peluang yang dihadapi para da’i dalam berdakwah kepada masyarakat perbatasan di Desa Badau.
Metode yang digunakan dalam penelitian ini adalah metode kualitatif.Sumber data utama adalah para da’i dan masyarakat Desa Badau sebagai mad’u dakwah.Teknik pengumpulan data yang dilakukan adalah wawancara dan observasi. Analisis data yang digunakan adalah pengumpulan data, reduksi data, display data, penarikan kesimpulan dan verifikasi.
Hasil penelitian ini menyimpulkan bahwa strategi dakwah di Desa Badau sudah cukup tepat dan sesuai diterapkan pada masyarakat Desa Badau yang mayoritas tingkat pengetahuan keagamannya rendah, hal ini menyebabkan tidak ada ideologi asing yang masuk ke Desa Badau, kesimpulan ini diambil berdasarkan: pertama, metode dakwah yang digunakan oleh para da’i di Desa Badau Kecamatan Badau Kabupaten Kapuas Hulu bervariasi diantaranya dakwah bil-Lisan, bil-Hal, bil-Hikmah, dan al-Mauidzatil Hasanah. Kedua, materi dakwah yang disampaikan oleh para da’i di Desa Badau Kecamatan Badau Kabupaten Kapuas Hulu adalah tentang Aqidah dan Fiqh dasar. Ketiga, media dakwah yang digunakan oleh para da’i di Desa Badau Kecamatan Badau Kabupaten Kapuas Hulu belum ada yang khusus karena belum lengkapnya akses media dakwah yang dapat digunakan dan kurangnya pengetahuan da’i tentang penggunaan media dakwah modern.Keempat, Peluang Dakwah di Desa Badau Kecamatan Badau Kabupaten Kapuas Hulu sangat terbuka, diantaranya antusiasme mad’u menerima pesan dakwah dan penggunaan media modern yang belum begitu banyak, sedangkan hambatan dakwahnya adalah kurangnya partisipasi da’i dalam pengembangan dakwah secara intensif.
Antibacterial activity, quality and stability study of creams with new potential silver(I) complexes and in vivo case report
Authors: Sovová Simona , Megyesi Štefánia Laca , Mudroňová Dagmar , Mudroň Pavol , Harvanová Jarmila , Rendošová Michaela , Goga Michal , Tkáčiková Ľudmila , Vargová Zuzana 
Published: June 2023

Abstract
The aim of this study was to evaluate the antibacterial activity, quality and stability of creams (at 1 % concentration) prepared with synthesized silver(I) complexes: [Ag(Nam)2]NO3·H2O ( AgNam), [Ag2(HGly)2]n(NO3)2n (AgGly) (Nam – nicotin-amide, Gly – glycine) and silver(I) sulfadiazine (AgSD), which is commercially available. Antibacterial activity was evaluated by agar well diffusion method and in in vivo case. The pure silver(I) complexes as well as all three tested creams loaded with AgGly, AgSD and AgNam showed antibacterial potential. Moreover, the creams loaded with AgGly and AgNam showed higher antibacterial effects against S. aureus and B. subtilis than the cream loaded with AgSD. In terms of appearance, all cream samples were opaque and odourless, and no phase separation was observed. Creams were soluble in water (o/w emulsions) and they had a pseudoplastic behaviour. The pH of the creams was in the range of 4.87–5.75. No visible changes were observed in the case of commercially used AgSD cream during one month testing period at conditions –16 ± 1 °C; 6 ± 1 °C and 56 % relative humidity; 20 ± 1 °C and 58 % relative humidity and 40 ± 1 °C and 75 % relative humidity. However, creams containing AgGly and AgNam changed their colour depending on the tested conditions.
Pharmaceutical approaches for COVID-19: An update on current therapeutic opportunities
Authors: Fan Sijia , Wang Hongling , Wu Dean , Liu Lu 
Published: June 2023

Abstract
SARS-CoV-2, a newly discovered coronavirus, has been linked to the COVID-19 pandemic and is currently an important public health issue. Despite all the work done to date around the world, there is still no viable treatment for COVID-19. This study examined the most recent evidence on the efficacy and safety of several therapeutic options available including natural substances, synthetic drugs and vaccines in the treatment of COVID-19. Various natural compounds such as sarsapogenin, lycorine, biscoclaurine, vitamin B12, glycyrrhizic acid, riboflavin, resveratrol and kaempferol, various vaccines and drugs such as AZD1222, mRNA-1273, BNT162b2, Sputnik V, and remdesivir, lopinavir, favipiravir, darunavir, oseltamivir, and umifenovir, resp., have been discussed comprehensively. We attempted to provide exhaustive information regarding the various prospective therapeutic approaches available in order to assist researchers and physicians in treating COVID-19 patients.
Orthodontic considerations for patients presenting with Goldenhar Syndrome: A long-term case report
Authors: Fowler Peter , Gray Emily , Haworth Jennifer 
Published: June 2023

Abstract

Introduction
The correction of facial asymmetry in patients presenting with Goldenhar Syndrome can be challenging due to the complexity of the orthodontic and surgical procedures required, the psychosocial considerations of the patient and the risk of relapse.

Materials and methods
A Caucasian male with Goldenhar Syndrome originally presented at age 8.2 years with concerns relating to a poor bite. He had previously undertaken surgery for the removal of pre-auricular skin tags on the right side. With ongoing skeletal growth, the facial asymmetry became more obvious and caused the patient to become socially withdrawn. Multidisciplinary treatment involving orthodontics and orthognathic surgery to correct the mandibular asymmetry was delayed until facial growth had slowed. The correction involved the use of an asymmetrical bilateral sagittal split osteotomy and an advancement genioplasty followed by a dermal fat graft and MedporR onlay to the right mandibular body and angle in addition to a refinement genioplasty.

Results
Follow-up has revealed a partial return of a buccal openbite illustrating the risk of occlusal relapse.

Conclusion
The case report illustrates the complexity of the orthodontic and surgical management of facial asymmetry, the psychosocial considerations of the patient and the risk of relapse. Multidisciplinary management is essential in the management of Goldenhar Syndrome.
Examining Types and Duration of Teachers’ Professional Development Activities and Their Relationship with Job Satisfaction
Authors: Ilgan Abdurrahman , Basaran Yagmur 
Published: June 2023

Abstract

Introduction:
The aim of the study was to describe the teachers’ views on the professional development activities, the frequency of the teachers’ participation to such activities and effectiveness of these professional development (PD) activities. What’s more, it was aimed to analyse the relationship between PD activities that the teachers participated and their job satisfaction (JS).

Methods:
The sample of the study comprised of 357 teachers. In order to seek the answers to the research questions, correlational research models were used in addition to survey. The data was collected through implementation of two different instruments. These were Participation to PD Activities Questionnaire (survey) and Job Satisfaction (JS) Scale. These instruments were developed within the scope of the study.

Results:
The findings of the study could be summarized as follows: the teachers’ frequency of participation to peer coaching-based PD activities, participated PD activities, number of individualized and self-directed PD activities was at a lower level; however, the teachers restated that they experienced positive effects at higher or moderate levels from PD activities in their teaching practices. Within the scope of the existing study the hypothesis was tested that PD activities would increase the teachers’ job satisfaction and the findings were supported. It was seen that there was a positive relationship between the PD activities participated by the teachers and the teachers’ job satisfaction.

Discussion:
In the study it was noticed that more than one third of the participant teachers did not perform PD based peer coaching and observations, but more than one third of the teachers accessed virtual platforms and watched videos and related feed on lecturing and techniques for PD. In TALIS study done at OECD countries, it was noted that almost half of the teachers participated to peer coaching-based activities.

Limitations:
Data were collected from teachers that research is limited with teachers’ perceptions. Research is limited with teachers’ professional development activities and their job satisfaction.

Conclusions:
It was found out that very few teachers attended educational congresses to present their activities/scientific studies. Therefore, it might be recommended to improve teachers’ study skills in terms of scientific studies, and they might be encouraged to present their studies at conferences.
Roma Mentor Project: The Roma Intellectual Friend Model
Authors: Bogdán Péter 
Published: June 2023

Abstract

Introduction:
The Roma Mentor Project has originally been the experimental educational model of Open Society Institute for multiply disadvantaged Roma and non-Roma youth in the period 2006-2013. Following the closure of OSI’s experimental and alternative educational projects, it has been run further, during the 2016/17 academic year, with the support of the Norway Grant, by the Bhim Rao Association (located in Northern Hungary).

Purpose:
The Roma Mentor Project aims to establish the pedagogical model of the intellectual Roma friend in order to effectively overcome the sociocultural disadvantages of the Roma and non-Roma children with multiply disadvantages.

Methods:
Throughout the program a Roma mentor may be a Roma intellectual, artist or well-known figure from the media, whose primary goal is to act as a role model for the Roma children through presenting their own personal and professional life, as well as to become a friend of the mentored.

Conclusions:
A mentor from Roma origins appears during the project as a Roma intellectual friend in multiply disadvantaged Roma and non-Roma children’s lives, which is especially true considering that the Roma mentor draws tools of socialization from Roma culture.
Tunnel Parsing with Ambiguous Grammars
Authors: Handzhiyski Nikolay , Somova Elena 
Published: June 2023

Abstract
The article proposes an addition to the tunnel parsing algorithm that enables it to parse grammars having countable repetitions and configurations of grammar elements generating empty words without refactoring the grammar. The equivalency of trees built by the use of ambiguous grammar is discussed. The class of the ε-ambiguous grammars is defined as a subclass of the ambiguous grammars relative to these trees. The ε-deterministic grammars are then defined as a subclass of the ε-ambiguous grammars. A technique for linearly parsing on the basis of non-left recursive ε-deterministic grammars with the tunnel parsing algorithm is shown.
Analysis on Hacking the Secured Air-Gapped Computer and Possible Solution
Authors: Sati Vrinda , Muthalagu Raja 
Published: June 2023

Abstract
The world today runs on data, every minuscule task to the large one requires data. All the data is stored in the various technologies that we use. And to keep data safe, air gaps are introduced. Air gaps are a network security measure where secure computer networks are physically isolated from unsecured networks. Yet, different methods to hack the air gap have come forth. The paper analyzes the problem of hacking an air gap via screen brightness modulations. The proposed solution is a software program used to alert the user of a change in the brightness level of the screen. The concept of Windows Management Instrumentation (WMI) has been used to put forth the software. Applied to an air-gapped computer, the program displays an alert box immediately, as the screen brightness changes. The solution is an easy and efficient way to counter the attack. The program can be further implemented in different testing environments and the WMI concept can be applied to various other cyber hacks.
Achieving Sustainable Transportation from the Perspective of Road Accessibility and Regional Correlations of County Seats in Hungary
Authors: Kovács Áron , Tóth Tamás , Nagy Henrietta , Lévai Imre 
Published: June 2023

Abstract
Road traffic is a sub-sector, which has implications for almost all economic activity through transportation, and directly affects the economy and social processes of a region or country. The conscious and sustainable accessibility of the capital and county seats is particularly important in terms of goods distribution, labour mobility and access to services. Necessary research was conducted using Google Maps’ 2022 summer data and Hansen‘s gravity model. The study identifies county seats that require development and facilitates the mapping of regional relationships between the capital and the county seats.
New Trends of Omnichannel Operation in Retail Trade in the Visegrad Countries
Authors: Kozák Tamás József , Soós Gabriella , Neszmélyi György Iván 
Published: June 2023

Abstract
In the Visegrad countries, online sales increased generally by double-digit growth in the last 5 years. The research examines how the changing processes affected by the pandemic and consequently the macroeconomic environments and the distributors were confined because of the restrictions and lockdown of borders. It is observed that many traders moved toward the direct-to-consumer (DTC) strategy, so one of the research questions is how consumers could use the Internet for satysfing their needs. The pandemic has accelerated the changes in the value chains, and distribution channels, so the paper analyses how companies transformed their commercial models to omnichannel form. One of the other research questions is to determine the strength of the relationship between e-commerce’s gaining ground and the pandemic restriction in Visegrad countries. The role of innovation in the commercial branch, which have resulted in a more effective way, particularly disruptive technologies is stressed.
The political deduction and building political security In Sudan post of 2019
Authors: Hamsa Khatan Khalaf  
Published: June 2023

The political deduction in political security issues has become one of the topics that related with the attention of researchers and specialists. On the philosophical level, the deduction based on a certain reason to be as the basis for proving a specific issue that cannot be tackled by the existence of contradictions between two extremes - paradigm (Security and Instability). So that, the future of political security in Sudan is still instability, although the international community's ability to impose their Comprehensive Peace Agreement since February 2005, and according to the requirements of what included in the clauses of the agreement to complete the procurement of democratic transition period, as for the Sudanese opposition forces and the Sudan People's Liberation Movement which are represented the real partners of power. So, the ability of the National Congress Party at that time could have power to consolidate its inclusiveness as a dominant political party.
From the another hand, the possibilities to infer the dimensions of political security in Sudan are ready to restore the army’s control over the political life, but with the need to maintain the settlement of critical political issues according to a new criteria that take into account the demands of civil forces; However, the civilian leadership was still inactive by as a result of internal divisions and rivalries within, so that the local, regional and international pressures remain to be the only source of strength to achieve a kind of consensus and satisfaction to overcome the critical period and accomplish what can be achieved for the benefit of the political security for Sudan, at the present and future alike. Finally, the absence of mechanisms for managing the divergent interests between civil and military leaders may lead to an unstable civil-military alliance, and they concern about losing of the whole absolute privileges and powers that they enjoyed during the past three decades for the rule of former President Omar al-Bashir, leaving the civilian leadership in 2019 to be as a drastically situation in its inability to form a united front that pushed towards neutralizing the military’s authority or resorting to confront a new period as a returning of violence as what happened in the past. As for the multiplicity of factors affecting on the political security crisis in Sudan, it meant that there is no real solution to subsequent crises in the future, so that the possibility of shifting towards civilian rule remains the only way to manage differences. And the differences between civilians and military alike might erupted at any reason or incentive.
Training of Thesis Conversion into Scientific Articles
Authors: Abubakar Multazam , Tsuraya Annisa Shofa , Muthi’ah Muthi’ah , Nur Nur Aliyah , Nawir Muhammad Syahruddin 
Published: June 2023

Final-year students encounter problems in converting their thesis into scientific articles as one of the requirements from Ministry of Higher Education to graduate from university. This community service aimed at providing understanding to final-year students about writing scientific articles which are from their theses, how to use referencing manager, such as Mendeley and how to submit research article in scientific journal using OJS. The participant of this activitiy was the final-year students and fresh graduates of English Education Department, Faculty of Tarbiyah dan Teaching Science, UIN Alauddin Makassar. The method used in this activity named ’training’ by applying The Training Cyrcle approach. The training was held in four steps, they were identifying training needs, deciding the aims and planning of training, the implementation of training and evaluation. The result showed that the participants were enthusiastic in taking part in this training since the materials met their needs. Meanwhile, after the training, the students are able to understand to convert their theses into scientific articles, use referencing manager and make an account as well as submit their articles in journals using OJS.
Миграция населения в Туве по данным Всероссийской переписи населения 2020 года
Authors: Абылкаликов Салават Иргалиевич , Баймурзина Гузель Римовна , Баталов Роман Олегович 
Published: June 2023

В статье анализируются миграционные процессы в Республике Тыва на основе данных Всероссийской переписи населения 2020 года (ВПН–2020), проведенной осенью 2021 г. Рассмотрены основные характеристики миграционных контингентов: место рождения и особенности пожизненной миграции населения, продолжительность проживания и приживаемость в месте вселения, наличие регистрации по месту жительства и месту пребывания, характеристика лиц, временно находящихся на территории страны, а также проблемы качества статистики ВПН–2020 на уровне региона.
Результаты исследования показали, что в межпереписной период в Республике Тыва сократилось количество уроженцев других регионов России, а число приезжих из других стран, включая Киргизию, Казахстан и Китай, выросло. Большинство населения имеет постоянную регистрацию по месту жительства, но доля людей без постоянной регистрации в городах Тувы значительно выше, чем в сельской местности, особенно среди молодежи. Более половины жителей Тувы, указавших продолжительность проживания, не имели опыта долговременной миграции, особенно в сельском населении. Доля новосёлов в городской местности выше, чем в сельской, что является следствием продолжающейся урбанизации региона.
Исследование выявило, что несмотря на недостатки, перепись населения 2020 г. позволяет получить информацию о миграции населения под другим углом, нежели традиционно используемые данные текущего учета, и собрать уникальные данные о малочисленных группах населения, включая тех, кто обладает миграционным опытом.