bluuebunny/crossref_metadata_2025_split huggingface dataset:
Catalytic C−C/C−H Bond Activation Relay for Synthesis of Fluorescent Naphthoquinolizinium Salts
Authors: Ulč Jan , Jacko Jaroslav , Císařová Ivana , Pospíšil Lubomír , Nečas David , Kotora Martin 
Published: March 2023

AbstractHerein, we report the design and synthesis of a series of novel cationic nitrogen‐embedded polyaromatic hydrocarbons with a planar geometry. The synthetic pathway is based on catalytic C−C/C−H bond activation relay that enabled preparation of regioselectively 5,6,10,11‐tetrasubstituted naphtho[2,1,8‐ija]quinolizinium salts bearing various types of substituents. Single‐crystal X‐ray analyses of selected compounds confirmed planarity of the quinolizinium core. Most of the prepared compounds exhibited strong fluorescence (Φs up to >99 %) ranging from 420–600 nm depending on the substitution pattern. According to DFT calculations LUMO is always distributed over the quinolizinium framework regardless of the attached substituents, whereas delocalization of HOMO is related to the substitution pattern. Electrochemical measurements show irreversible reduction of all compounds, which is supported by the calculated location of LUMO orbitals.
Electrochemical properties of theCaNi4.8M0.2(MMg, Zn, and Mn) mechanical milling alloys used as anode materials in nickel‐metal hydride batteries
Authors: Karaoud Imen , Dabaki Youssef , Khaldi Chokri , ElKedim Omar , Fenineche Nouredine , Lamloumi Jilani 
Published: March 2023

AbstractThe present research work examines the electrochemical properties of CaNi4.8M0.2(MMg, Zn) type alloy applied as an anode in nickel metal hybrid batteries. Based on an extensive study of the CaNi4.8Mn0.2compound prepared by mecano‐synthesis; under an argon atmosphere, with a variation of milling time and weigh ratio, using a Retsch PM400 type ball mill. The experimental results show that the excellent electrochemical properties were obtained for a milling time of 40 h and a ball‐to‐powder weight ratio equal to 8:1. Based on this study, we examined electrochemically the CaNi4.8M0.2(MMg, Zn, and Mn) compound according to the optimized parameters. Several methods, such as galvanostatic polarization and potentiodynamic polarization, were applied to characterize these electrodes. CaNi4.8M0.2(MMg, Zn, and Mn) electrodes were activated, respectively, during the first, second, and third cycles. The maximum discharge capacity was about 87, 60, and 96 mAhg−1at ambient temperature. These electrochemical findings correlate with the kinetic results provided during a long cycle.
Epilepsy and cerebral developmental venous anomalies (DVAs): A systematic review
Authors: El Meskine Tahir , Li Jimmy , Reise Julia , Toffa Dènahin Hinnoutondji 
Published: March 2023

AbstractObjectiveCerebral developmental venous anomalies (DVAs) are frequent and rarely symptomatic. When symptomatic, DVAs may present with seizures; however, little is known about the characteristics of DVA‐related epilepsy. In this systematic review, we aim to describe the clinical and paraclinical features of patients with DVA‐related epilepsy.MethodsThis review was registered on PROSPERO (CRD42021218711). We searched the MEDLINE/PubMed and Scopus databases for case reports/series on patients with DVAs complicated by seizures. Studies describing patients with a potentially epileptogenic comorbid lesion close to their seizure focus were excluded. Descriptive statistical analyses were performed to synthetize patient characteristics. The methodological quality of each study was evaluated using a standardized appraisal tool.ResultsIn total, 66 patients were included from 39 articles. The frontal lobe was the most common location for DVAs. The superior sagittal sinus drained half of the DVAs. Seizures were inaugural in most cases, and the most common manifestations accompanying seizures were headaches. EEG was abnormal in 93% of cases, but only 26% had characteristic epileptic spikes. More than half the patients suffered a medical complication due to their DVA, with hemorrhage and thrombosis being the most common. Refractory seizures were encountered in 19% of individuals. At 12 months of follow‐up, 75% of patients were seizure free. Most included studies were at low risk of bias.SignificanceEpilepsy can be a complication of DVAs; these DVAs are mostly frontal or parietal, draining via the superior sagittal sinus or the vein of Galen.
Seismic excitation of offshore wind turbines and transition piece response
Authors: Hamilton Christopher M. , Abadie Christelle N. 
Published: March 2023

AbstractExpansion of the offshore wind industry in seismically active areas has raised concerns regarding the structural integrity of offshore wind turbines under earthquake loading. This paper details a 3D finite element study to investigate the behaviour of the structure, and in particular the transition piece (TP), under seismic loads. The work focuses on equivalent grouted connection and TP‐less designs, selected as promising design solutions for seismic zones. The numerical model is validated against a medium‐scale 4‐point bending laboratory test, and scaled up to a representative 8 MW turbine. The results show that cracking of the grout occurs due to earthquake excitation at the top of the TP; a location that is typically undamaged during monotonic loading. This can lead to excessive settlement of the transition piece and loss of axial capacity caused by deterioration of the grout‐steel bond and water ingress. The residual hub displacement after earthquake excitation is around 0.1 m. The global monotonic response post‐earthquake excitation is not significantly altered, with apparent stiffness and ultimate strength maintained. An equivalent TP‐less design is shown to have a 5% lower natural frequency than an equivalent grouted connection design, suggesting a reduced global stiffness, with reduced structural damping due to the absence of grout. However, TP‐less design eliminates the risk of grout deterioration and settlement and may therefore be a safer design option for offshore wind turbines installed in seismic zones in the future.
Retro walking treadmill training reduces C—reactive protein levels in overweight and obese young adults: A randomized comparative study
Authors: Soman Ajith , Chandy Sunil , Alkhathami Khalid , Ramamoorthy Baranitharan , Alqahtani Bijad 
Published: March 2023

AbstractBackground and AimsRetro walking has been shown to acquire a greater metabolic cost, placing a higher cardiopulmonary demand on the body, when compared with forward walking at a similar speed. The aim of this study was to compare the effect of retro walking with that of forward walking on C‐reactive protein (CRP) levels, body mass index (BMI) and blood pressure (BP) and to understand the influence of independent factors namely systolic blood pressure (SBP), diastolic blood pressure (DBP) and BMI on CRP in untrained overweight and obese young adults.MethodsThis was a randomised controlled trial whereby 106 participants underwent either retro walking (n = 53) or forward walking (n = 53) treadmill training four times a week for 12 weeks before and after which CRP, BMI, and BP levels were measured. Comparison of the measured values before and after intervention and between the groups was done and influence of BMI and BP on CRP levels was determined.ResultsBoth groups recorded a significant decrease (p < 0.001) in CRP, BMI, and BP levels postintervention. The participants who underwent retro walking training showed a significantly (p < 0.001) higher decrease in all the outcomes as compared with the forward walking group. C‐reactive protein levels were seen to be influenced by BMI and DBP.ConclusionRetro‐walking training leads to greater decrease in CRP, BMI, and BP when compared with forward walking, and CRP levels are influenced by BMI and DBP. Retro walking treadmill training can be used preferentially to bring about reduction in cardiovascular risk factors.
Improved heating floor thermal performance by adding PCM microcapsules enhanced by single and hybrid nanoparticles
Authors: Babaharra Oumayma , Choukairy Khadija , Faraji Hamza , Hamdaoui Said 
Published: March 2023

AbstractA heating floor is a low‐temperature emitter consisting of pipelines in which a fluid circulates between 35°C and 45°C. To ensure energy efficiency, occupant comfort, and building material durability, proper heat management is crucial in buildings. By using phase change materials (PCMs) in building envelopes, the indoor temperature can be regulated through the storage and release of thermal energy, which reduces energy consumption and enhances occupant comfort. In this study, we evaluated numerically a heating floor that incorporates a PCM enhanced by nanoparticles (NePCM). The aim of the numerical analysis is to assess the impact of the addition of single and hybrid nanoparticles in different proportions to the PCM layer on the thermal performance of the PCM‐based floor. Therefore, two main objectives are defined. The primary is to take advantage of the storage capacity of a PCM layer by integrating it into the ground; second, to evaluate the hot water temperature levels effect on the floor's performance. Additionally, we address the low thermal conductivity of PCM by enhancing PCM microcapsules with single and hybrid nanoparticles and comparing them to pure PCM. The numerical results obtained show that positioning the PCM microcapsules above the heating tubes (upper position) provides an optimum improvement in thermal performance. Moreover, the addition of hybrid nanoparticles within the base PCM, 1% of Cu mixed with 4% of Al2O3, allows an increase of 4°C, which relates to a reduction of 18% in the internal temperature amplitude and a phase shift of 6 h 30 min compared with the conventional heated floor in which there is no PCM.
Indigenous literacies: A look at pedagogies and policy in the Southwest United States
Authors: Martinez Natalie 
Published: March 2023

AbstractLiteracy engagement for Indigenous peoples is a practice embedded in lived experience as thoughtful ways to communicate with and make sense of the world around us. Indigenous literacies involve the melding of Indigenous ways of knowing with contemporary educational pedagogies. Indigenous authors and teachers have long used Indigenous pedagogies in their writing and teaching to situate Indigenous identities and knowledge where it has been omitted, to interrogate the systems that appropriate or misarticulate Indigenous knowledge, to actively question spaces where the value and power of Indigenous knowledge is completely disregarded, and to reclaim or create spaces that amplify Indigenous voices and ways of knowing for learners as acts of education sovereignty. This column discusses the concepts of Indigenous literacy, it provides an overview of its practical applications in the US Southwest and the Native American education policies that shape literacy engagement in contemporary learning spaces centering on Indigenous perspectives.
Bilirubin–biliverdin concentration measurement using photoacoustic spectroscopic analysis for determining hemorrhage age
Authors: Manwar Rayyan , Gelovani Juri G. , Avanaki Kamran 
Published: March 2023

AbstractThe onset of intracerebral hemorrhage and its progression toward acute brain injury have been correlated with the concentration of unconjugated bilirubin (BR). In addition, BR has been considered a novel predictor of outcome from intracranial hemorrhage. Since the existing invasive approach for determining localized BR and biliverdin (BV) concentration within the hemorrhagic brain lesion is not feasible, the predictive capability of BR in terms of determining the onset of hemorrhage and understanding the consequences of its progression (age) is unknown. In this study, we have demonstrated a photoacoustic (PA) approach to the noninvasive measurement of BR–BV ratio that can be utilized longitudinally to approximate the onset of the hemorrhage. The PA imaging‐based measurements of BV and BR in tissues and fluids can potentially be used to determine hemorrhage “age,” quantitatively evaluate the hemorrhage resorption or detect a rebleeding, and assess responses to therapy and prognosis.
Polymyxin B exerts nephrotoxicity effects via inhibition of the Nrf2/NQO1 pathway‐mediated antioxidant response
Authors: Xiao Guiying , Yuan Fang , Deng Yang , Xiang Debiao , Xiong Liguang , Li Xin , Li Yuan 
Published: March 2023

AbstractPolymyxin B (PMB) is a polypeptide antibiotic widely used in treating multidrug‐resistant Gram‐negative bacteria. However, nephrotoxicity is a serious adverse effect that limits its clinical use. Therefore, clarification of the molecular mechanism of PMB‐induced renal injury is essential. Our study aimed to explore possible mechanisms of PMB‐induced nephrotoxicity in vivo and in vitro. Mice were treated with PMB to construct the kidney injury model. The antioxidant capacity was assessed by measuring the superoxide dismutase (SOD) and catalase (CAT) activities and the glutathione (GSH) and malondialdehyde (MDA) contents. The pathway of the nuclear factor erythroid 2‐related factor 2/NADH quinone oxidoreductase 1 (Nrf2/NQO1) was examined after PMB treatment in NRK‐52E cells and mice. Finally, the expressions of genes and proteins (Bax, Bcl‐2, Caspase‐3, Caspase‐9) related to apoptosis were evaluated through quantitative polymerase chain reaction and western blot assay. The study verified PMB‐induced nephrotoxicity in mice and NRK‐52E cells in a dose‐ and time‐dependent manner. PMB treatment significantly decreased the expression of Nrf2 and its downstream target gene NQO1 and increased the apoptosis‐related proteins expression. In summary, our results suggested that PMB‐induced oxidative stress damage by inhibiting the Nrf2/NQO1 pathway and promoting apoptosis in kidney tissues.
Protective role of hispolon and its derivatives against apoptosis in cortical neurons induced by electromagnetic radiation from 4G mobile phone
Authors: Saka Vara Prasad , V. Chitra , Narayanasamy Damodharan 
Published: March 2023

AbstractElectromagnetic radiation (EMR) from wireless devices, particularly mobile phones, is a potentially growing public health concern. In this study, the neuronal effects of EMR on primary cortical neurons (PCNs) from neonatal rat cerebral cortex and the protective role of hispolon (HIS) and its derivatives were investigated as a measure of cranial exposure during mobile phone use. PCNs were isolated and cultured from day‐old neonatal rats, then exposed for 2 h to EMR emitted by a mobile phone operating at a frequency of 2100 MHz with 1.6 W/Kg specific absorption rate (SAR) in call‐answered mode treated with HIS and its derivatives. The induction of apoptosis through modulation of pro and anti‐apoptotic genes via mitochondrial pathway and the protection by the test compounds was assessed. Pyrazole derivatives decreased apoptosis by modulating the levels of pro and anti‐apoptotic genes by reducing the levels of reactive oxygen species (ROS) via mitochondrial damage, which was observed in the EMR exposed PCNs. The pyrazole compounds were found to have antioxidative and anti‐apoptotic properties. Thus, the neuroprotective mechanisms of the pyrazole derivatives can be investigated further, which may make them appropriate as lead compounds in developing neuroprotective formulations.
SUZ12 promotes the malignant behavior of gastric cancer cells by CDKs
Authors: Guo Li , Zhang Caiqun 
Published: March 2023

AbstractZeste 12 Homolog (SUZ12), as a transcription factor, has been found to be highly expressed in a variety of tumors and promote tumor progression. We focus on revealing its role and mechanism in gastric cancer. Cellular level studies were conducted in mouse gastric cancer MFC cells by performing overexpression of SUZ12, overexpression of CDK6, and treatment with CDK6 inhibitor, respectively. Changes in cell viability, invasion, metastasis and colony formation were detected, and the expression variations of cell cycle regulatory proteins CDK6, P21, and Cyclin D were determined. During the animal experimentation, a mouse xenograft model was established. After transplantation of SUZ12‐overexpressing MFC‐SUZ12, the tumor growth was compared with that in MFC, and the tissue expressions of CDK‐6, SUZ12, and Cyclin D were examined. Overexpression of SUZ12 could enhance the viability of MFC cells while upregulating their migration, invasion and colony formation abilities, which promoted the expression of CDK6, P21, and Cyclin D. CDK6 inhibitor, on the other hand, could suppress the effects of SUZ12 overexpression and weaken the cell viability and malignant behavior. Overexpression of CDK6 also promoted the MFC viability and malignant behavior. We found that SUZ12 exerted its effects by promoting the expression of downstream cyclin CDK6. At the animal level, the mice xenografted with SUZ12‐overexpressing MFC cells exhibited larger tumor volumes, as well as elevated cyclin expression. SUZ12 promotes the proliferation and malignant behavior of gastric cancer cells by regulating the expression of downstream CDK6.
Impact of Basel III liquidity and capital regulations on bank lending and financial stability: Evidence from emerging countries
Authors: Sharma Anil K. , Chauhan Rosy 
Published: March 2023

AbstractWe examine the impact of Basel III's liquidity requirements, such as the liquidity coverage ratio (LCR), net stable funding ratio (NSFR), and capital adequacy, on bank lending and financial stability using data from 688 commercial banks of 10 developing economies from 2014 to 2021 using fixed effects panel estimation. The findings of the study support that bank lending is positively impacted by the regulatory capital and the short‐term liquidity requirement (LCR), but negatively impacted by the NSFR. We find that the bank's Z‐score benefits from achieving the required capital and liquidity requirements. Lending growth and bank stability are nonlinearly impacted by regulations governing bank capital and liquidity. Furthermore, we use the Generalized Methods of Moments‐Quantile Regression (GMM‐QR). Finally, our results indicate that regulators in these developing countries should support adequate capital and liquidity management to lessen adverse economic shocks' impact on banks' intermediation capabilities and stability.
Endothelial cells release microvesicles that harbour multivesicular bodies and secrete exosomes
Authors: Petersen Jennifer D. , Mekhedov Elena , Kaur Sukhbir , Roberts David D. , Zimmerberg Joshua 
Published: March 2023

AbstractExtracellular vesicles (EVs) released by endothelial cells support vascular homeostasis. To better understand endothelial cell EV biogenesis, we examined cultured human umbilical vein endothelial cells (HUVECs) prepared by rapid freezing, freeze‐substitution, and serial thin section electron microscopy (EM). Thin sections of HUVECs revealed clusters of membrane protrusions on the otherwise smooth cell surface. The protrusions contained membrane‐bound organelles, including multivesicular bodies (MVBs), and appeared to be on the verge of pinching off to form microvesicles. Beyond cell peripheries, membrane‐bound vesicles with internal MVBs were observed, and serial sections confirmed that they were not connected to cells. These observations are consistent with the notion that these multi‐compartmented microvesicles (MCMVs) pinch‐off from protrusions. Remarkably, omega figures formed by fusion of vesicles with the MCMV limiting membrane were directly observed, apparently releasing exosomes from the MCMV. In summary, MCMVs are a novel form of EV that bud from membrane protrusions on the HUVEC surface, contain MVBs and release exosomes. These observations suggest that exosomes can be harboured within and released from transiting microvesicles after departure from the parent cell, constituting a new site of exosome biogenesis occurring from endothelial and potentially additional cell types.
Development of an electrochemical surface‐enhanced Raman spectroscopic biosensor for the direct detection of glutathione
Authors: Chotoye Sumayyah A. B. , Eisnor Maddison M. , Ball Rachael B. E. , Brosseau Christa L. 
Published: March 2023

AbstractGlutathione is an important biological free radical scavenger, aiding in the prevention of oxidative stress in living organisms. A decrease in glutathione concentration in cells or bodily fluids is associated with serious health issues including certain cancers and Alzheimer's disease. Rapid detection and quantification of salivary glutathione could play a crucial role in healthcare monitoring as well as in therapeutic progress. This paper reports on the development of a direct electrochemical surface‐enhanced Raman spectroscopic (EC‐SERS) method for the monitoring of glutathione deposited via drop casting from a prepared aqueous stock solution and measured in 0.1‐M sodium fluoride and in artificial saliva. The detection platform for this study is constructed by modifying the working electrode of a carbon screen‐printed electrode with silver nanoparticles of approximately 30 nm in diameter, followed by potassium chloride treatment to remove interfering citrate anions prior to analysis. The coupling of SERS and an applied electrochemical potential resulted in a significantly enhanced spectrum for glutathione compared with those previously reported. Vibrational mode assignment confirmed that glutathione was indeed in close proximity to the surface of the working electrode and had varying anchor points as the potential was stepped anodically. Quantitative analysis of glutathione in artificial saliva showed that the 653 cm−1 marker peak intensity varies linearly (R2 = 0.990) over the concentration of 0.005–1.00 mM on the modified electrode surface. The signal limit of detection of glutathione using EC‐SERS in artificial saliva was determined to be 5 μM. This direct and rapid EC‐SERS detection platform is promising for point‐of‐care diagnostics.
Characterizing quality traits of boiled yam: texture and taste for enhanced breeding efficiency and impact
Authors: Adinsi Laurent , Djibri‐Moussa Imayath , Honfozo Laurenda , Bouniol Alexandre , Meghar Karima , Alamu Emmanuel O. , Adesokan Michael , Arufe Santiago , Ofoeze Miriam , Okoye Benjamin , Madu Tessy , Hotègni Francis , Chijioke Ugo , Otegbayo Bolanle , Dufour Dominique , Hounhouigan Joseph D. , Ceballos Hernán , Mestres Christian , Akissoé Noël H. 
Published: March 2023

AbstractBACKGROUNDBoiled yam key quality attributes typical for West African consumers are that it is crumbly, easy to break and has a sweet taste. New yam varieties are being developed but high‐ or medium‐throughput tools to assess the required quality traits and their range of acceptance are limited. This study assessed the acceptance thresholds of these quality attributes and established predictive models for screening yam varieties that meet the required consumer preferences.RESULTSOverall liking was associated with sweet taste, crumbliness and easiness to break (r‐values 0.502, 0.291 and −0.087, respectively). These parameters and selected biophysical parameters highly discriminated the boiled yam varieties. Crumbly texture and easiness to break were well predicted by penetration force and dry matter, whereas sweet taste were well predicted by dry matter and sugar intensity. A high crumbliness and sweet taste are preferred (sensory scores above 6.19 and 6.22 for crumbly and sweet taste, respectively, on a 10 cm unstructured line scale), while a too high easiness to break is disliked (sensory scores ranging from 4.72 to 7.62). Desirable biophysical targets were between 5.1 and 7.1 N for penetration force, dry matter around 39% and sugar intensity below 3.62 g 100 g−1. Some improved varieties fulfilled the acceptable thresholds, and screening was improved through deviation from the optimum.CONCLUSIONAcceptance thresholds and deviation from optimum for boiled yam assessed through the instrumental measurements are promising tools for yam breeders. © 2023 The Authors. Journal of The Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.