bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk factors for sessile serrated lesions among Chinese patients undergoing colonoscopy
Authors: Zhang Ru , Ni Yunbi , Guo Cosmos LT , Lui Rashid NS , Wu William KK , Sung Joseph JY , Wong Vincent WS , Wong Sunny H 
Published: May 2023

AbstractBackground and AimSerrated polyps have been recognized as a premalignant lesion accounting for a significant proportion of colorectal cancer. Limited data are available regarding the risk factors for colorectal sessile serrated lesions (SSLs). We aimed to investigate clinical risk factors of SSLs and compared them with colorectal adenomas in a study population of Chinese individuals.MethodsA retrospective case–control study was performed in an academic tertiary‐referral center in Hong Kong. Subjects with SSLs and adenomas were identified from the hospital pathology database from January 2010 to December 2020, and additional clinical data were retrieved from the electronic patient record system. We compared clinical features and risk factors of SSL patients with those without these lesions.ResultsA total of 2295 subjects were included in the study, including 459 subjects with SSLs, 918 subjects with adenomas, and 918 subjects with normal colonoscopy. By multivariable logistic regression, compared with normal subjects, patients with SSLs only were significantly more likely to have dyslipidemia (adjusted OR: 1.431, 95% CI 1.008–2.030) and diabetes mellitus (adjusted OR: 2.119, 95% CI 1.439–3.122).ConclusionsDyslipidemia and diabetes were independent risk factors for SSLs. Our findings suggest these metabolic factors may be important for the risk of SSLs. The findings may improve our understanding of SSLs and shed light on patient selection for screening and risk stratification.
KNDyneurones andGnRH/LHpulse generation: Current understanding and future aspects
Authors: Uenoyama Yoshihisa , Tsukamura Hiroko 
Published: May 2023

AbstractUncovering the central mechanism underlying mammalian reproduction is warranted to develop new therapeutic approaches for reproductive disorders in humans and domestic animals. The present study focused on the role of arcuate kisspeptin neurones (also known as KNDy neurones) as an intrinsic gonadotropin‐releasing hormone (GnRH) pulse generator, which plays a fundamental role in mammalian reproduction via the stimulation of pituitary gonadotropin synthesis and release and thereby in gametogenesis and steroidogenesis in the gonads of mammals. We also discuss the mechanism that inhibits pulsatile GnRH/gonadotropin release under a negative energy balance, considering that reproductive disorders often occur during malnutrition in humans and livestock.
Long‐term efficacy and safety of a hyaluronic acid dermal filler based on Tri‐Hyal technology on restoration of midface volume
Authors: Kestemont Philippe , Fanian Ferial , Garcia Philippe , Grand‐Vincent Anne , Benadiba Laurent , Delmar Henry , Bodokh Isaac , Brun Patrick , Braccini Frédéric , Desouches Christophe , Paris Jérôme , Nadra Karim , Salomon Catherine , Trevidic Patrick 
Published: May 2023

AbstractIntroductionArt Filler Volume (AFV) is a hyaluronic acid (HA)‐based filler formulated with “Tri‐Hyal” technology, a unique combination of three sizes of HA chains. This study assessed AFV efficacy and safety over 18 months when used to restore midface volume.MethodsDuring this open‐label study, a maximum of 1.8 mL AFV was injected into each cheek area on Day 0 (D0). Subjects were evaluated at D21, when, if necessary, a retouch could be performed (maximum 1.2 mL per cheek). Subjects were evaluated at seven follow‐up visits through to D540. The primary assessment was based on the evolution of the Medicis Midface Volume Scale (MMVS) grade on D21. Secondary outcomes were local and general adverse events, investigator‐ and subject‐assessed Global Aesthetic Improvement Scale scores and changes in self‐esteem.ResultsOf the 79 healthy Caucasians enrolled (mean age 54.8 years), 25 required a second injection. In the intention‐to‐treat population, mean overall MMVS scores improved significantly from D0 (3.2 ± 0.4) to D21 (1.8 ± 0.6) and D42 (1.7 ± 0.6) (all p < 0.0001). MMVS scores for each cheek also improved significantly, irrespective of retouch on D21: 22% of injections showed a persistent benefit at D540 without retouch. The most common adverse events were pain on palpation (19%), erythema (15%) and edema (13%); most were mild or moderate and resolved within 2 weeks.ConclusionAFV produces a sustained objective and subjective midface volume restoration in female and male subjects, often without retouching, and was well tolerated.
Translating Buen Vivir: Latin American Indigenous Cultures, Stadial Development, and Comparative Religious Ethics
Authors: Lantigua David 
Published: May 2023

ABSTRACTThis article considers the methodological limits and possibilities of a cultural turn in comparative religious ethics by “translating” the Latin American Indigenous meanings of buen vivir (living well), a subsistent mode of interdependent flourishing resistant to Western models of extractive development amid the Anthropocene. It problematizes the methodological challenge of translating Indigenous cultures from within a Western colonial political economy that has historically relegated Indigenous Americans to the primitive level of savage inferiority according to a stadial theory of socioeconomic development. However, constructive methodological options for translating Indigenous cultures emerge from the Journal of Religious Ethics's existing conversations about comparative religious ethics. On the one hand, recent critical anthropology and ethnography, abetted by intellectual history, provide tools for ethicists in the recovery of Indigenous critiques and meanings against longstanding Western cultural patterns. On the other hand, nativizing the concept of the religious classic thematizes the normative dimensions of Indigenous cultures, demonstrating how the translation of buen vivir points to intercultural dialogue rather than cooptation and manipulation.
The nutritional strategy of European rabbits is affected by age and sex: Females eat more and have better nutrient optimisation
Authors: Marín‐García Pablo‐Jesús , Llobat Lola , Aguayo‐Adán Juan Antonio , Larsen Torben , Cambra‐López María , Blas Enrique , Pascual Juan José , Rouco Carlos 
Published: May 2023

AbstractThe ecological interest in the European rabbit (Oryctolagus cuniculus) has grown since it was declared an endangered species. Nutrition is fundamental in its dispersion and the key to its success. This is the main reason why knowledge of their nutritional preferences/requirements could play a fundamental role in rabbit biology and, therefore, in their conservation. The objectives of the work will be to elucidate how age and sex affect both nutritional preferences/requirements, and the nutrient optimisation of European rabbits. To address this gap, 70 wild European rabbits were studied. The rabbits were divided according to their age: adult (n = 43) and young (n = 27). Two groups were differentiated according to the adult rabbits' sex: females (n = 28) and males (n = 15). We analysed the relative (%) and absolute (g) chemical composition of the rabbits' gastric contents: dry matter (DM), ashes (ASH), crude protein (CP), ether extract (EE), neutral detergent fibre (NDF), acid detergent fibre (ADF), and lignin, hemicelluloses and celluloses, highly digestible nonnitrogenous nutrients (HDNN: fat, starch, and soluble fibre), well from the blood was analysed with plasmatic urea nitrogen (PUN), nonesterified fatty acid (NEFA) and glucose (GLU). As a nutrient optimisation measure, the following indices between blood metabolites and stomach content were calculated: PUN/CP total content, NEFA/DM total content and GLU/DM total content ratios. Our works showed that age and sex affected the nutritional strategy of rabbits. Regarding age: adults showed lower CP (−14%; p = 0.0217) and higher HDNN (+21%; p = 0.0399) relative content than young rabbits, and absolute amount of most nutrients: DM (+59%; p = 0.001), OM (+43%; p = 0.0049), ASH (+54%; p = 0.0085), Hemicelluloses (+73%; p = 0.0084), Cellulose (+27%; p = 0.0452), and HDNN (+63%; p = 0.0012). In addition, adults showed better nutrient optimisation. Sex did not affect the relative chemical composition of the gastric content, but it showed a clear higher gastric content by females (+85%; p < 0.0001) and higher intake of most of the absolute chemical components: DM (+64%; p < 0.001), CP (+56%; p = 0.0005), OM (+58%; p = 0.0001), ASH (+44%; p = 0.0123), HDNN (+39%; p = 0.001), NDF (+59%; p = 0.001), ADF (+64%; p = 0.0003), lignin (+82%; p = 0.0036) and cellulose (+58%; p = 0.0002). Finally, we observed that females had better nutrient optimisation than males. This works supports the idea that feeding ecology and nutrition are particularly relevant to reproductive success and fitness in wild animals.
Effect of Brazilian spinach (Alternanthera sissoo) pellet supplementation and dietary ratios on rumen characteristics, microorganisms, methane production, milk yield, and milk composition in dairy cows
Authors: Sommai Sukruthai , Wanapat Metha , Prachumchai Rittikeard , Cherdthong Anusorn 
Published: May 2023

AbstractThe aim of the previous research was to evaluate the effects of Brazilian spinach pellet (BSP) supplementation and dietary ratios on rumen characteristics, methane estimation, and milk production in dairy cows. Four crossbred Thai dairy cattle, with Holstein Friesian (HF) cows with a body weight of 442 ± 50 kg were assessed in a 2 × 2 factorial in a 4 × 4 Latin square design to obtain diets; factor A was the roughage (R) to concentrate (C) ratio at 40:60 and 30:70, and factor B was level of BSP supplantation at 2% and 6% of dry matter (basis) intake (DMI). R:C ratio and supplementation of BSP had no interaction effect on DMI and nutrient digestibility. On DM, organic matter (OM), crude protein (CP), and acid detergent fiber (ADF) intake, the R:C ratio increased (p < 0.05). The digestibility of OM improved (p < 0.05) when cows were fed a R:C ratio of 30:70. On pH, ammonia‐nitrogen, protozoal population, and blood urea‐nitrogen, there were no interactions between the R:C ratio and BSP supplementation. Increasing the BSP supplementation to 6% (p < 0.01) decreased the protozoal population. The R:C ratio of 30:70 increased total volatile fatty acid (VFA) and propionate (C3) concentrations while decreasing the acetate (C2) to C3 ratio and methane (CH4) estimation (p < 0.01). The average concentration of total VFA has increased by 114.46 mmol/L for 6% of BSP supplementation. Increased BSP supplementation increased the C3 concentration while decreasing the C2:C3 ratio and CH4 emissions (p < 0.05). The R:C ratio and BSP supplementation had no interaction effect on milk yield, 3.5% fat‐corrected milk (FCM), or milk composition. The R:C ratio of 30:70 increased milk yield (p < 0.05) to the highest level of 12.18 kg/day. In conclusion, the diet containing a R:C ratio of 30:70 increased feed intake, milk yield, BUN, total VFA, and C3 concentration, and decreased the C2:C3 ratio and CH4 emission. BSP supplementation at 6% could increase TVFA and C3 concentrations while decreasing the protozoal population and CH4 estimation.
Adolescents’ Change in Motivation as a Result of Buddhist Education: How Does It Make a Difference in Their Learning Outcomes?
Authors: Tan Le Loc 
Published: May 2023

AbstractMotivation significantly influences students’ learning outcomes. Changing their learning motivation improves their performance. This study used an exploratory sequential mixed methods approach, with the participation of 140 adolescents attending retreats at three Zen monasteries belonging to the Truc Lam (Bamboo Forest) Zen sect, to examine how they changed their motivation, what made them change, and how the change improved their learning outcomes. The study also evaluated the effect of gender and age on changes in motivation. The results indicated that many teenagers had changed from extrinsic to intrinsic motivation thanks to Dharma lessons, teacher support, and leisure activities. Compared to students who maintained their extrinsic motivation unchanged, they had better learning outcomes. Age, but not gender, had a considerable effect on changes in teenagers’ motivation. These findings provide more evidence for extending Buddhist education and conducting further research on young Buddhist learners’ motivation in various contexts.
Optimal rate control in dogs with atrial fibrillation—ORCA study—Multicenter prospective observational study: Prognostic impact and predictors of rate control
Authors: Pedro Brigite , Mavropoulou Antonia , Oyama Mark A. , Linney Christopher , Neves João , Dukes‐McEwan Joanna , Fontes‐Sousa Ana P. , Gelzer Anna R. 
Published: May 2023

AbstractBackgroundThe optimal heart rate (HR) in dogs with atrial fibrillation (AF) is unknown. Impact of HR on survival needs elucidation.Hypothesis/ObjectivesDogs with a 24 hours Holter‐derived meanHR ≤125 beats per minute (bpm; rate controlled) survive longer than dogs with higher meanHR. We further aimed to determine which variables predict ability to achieving rate control.AnimalsSixty dogs with AF.MethodsHolter‐derived meanHR, clinical, echocardiographic, and biomarker variables were analyzed prospectively. Survival was recorded from time of rate control, with all‐cause mortality as primary endpoint. Cox proportional hazards analysis identified variables independently associated with survival; Kaplan‐Meier survival analysis estimated the median survival time of dogs with meanHR ≤125 bpm vs >125 bpm. Logistic regression explored baseline variables associated with inability to achieve rate control.ResultsStructural heart disease was present in 56/60 dogs, 50/60 had congestive heart failure, and 45/60 died. Median time to all‐cause death was 160 days (range, 88‐303 days), dogs with meanHR >125 bpm (n = 27) lived 33 days (95% confidence interval [CI], 15‐141 days), dogs with meanHR ≤125 bpm (n = 33) lived 608 days (95% CI, 155‐880 days; P < .0001). Congenital heart disease and N‐terminal pro‐B‐type natriuretic peptide were independently associated with higher risk of death (P < .01 and <.0001, respectively) whereas meanHR ≤125 bpm decreased the risk of death (P < .001). Increased left atrial size, increased C‐reactive protein concentration and lower blood pressure at admission were associated with failure to achieve rate control.Conclusions and Clinical ImportanceRate control affects survival; an optimal target meanHR <125 bpm should be sought in dogs with AF. Baseline patient variables can help predict if rate control is achievable.
Effects of calcium supplementation to resuscitation fluids in endurance horses: A randomized, blinded, clinical trial
Authors: Fielding C. Langdon , Deane Emma L. , Major Dustin S. , Mayer Jennifer R. , Love Juliette C. , Peralez Michael S. , Magdesian K. Gary 
Published: May 2023

AbstractBackgroundThe addition of calcium to resuscitation fluids is a common practice in horses, but studies evaluating the effects of calcium supplementation are limited. In healthy horses, decreases in heart rate and changes in serum electrolyte concentrations have been reported.HypothesisCalcium gluconate administration at a rate of 0.4 mg/kg/min to eliminated endurance horses with metabolic problems will affect heart rate, gastrointestinal sounds, and serum electrolyte concentrations.AnimalsEndurance horses eliminated from the Tevis Cup 100‐mile (160 km) endurance ride for metabolic problems and requiring IV fluid therapy were eligible.MethodsSixteen horses were randomly assigned to receive 0.4 mg/kg/min of calcium (23% calcium gluconate solution) over 1 hour diluted in 10 L of a non‐calcium containing isotonic crystalloid (CAL group) or 10 L of a non‐calcium containing isotonic crystalloid (CON group). Staff members administering the fluids were blinded to treatment group. Blood samples were collected and physical examinations performed before and after treatment. Heart rates were recorded every 15 min during fluid administration. Data were compared using 2‐way analysis of variance (ANOVA) with repeated measures for continuous variables and Fisher's exact test for categorical variables.ResultsCalcium was associated with lower heart rates 45 min after starting the infusion (P = .002). Gastrointestinal sounds were less likely to improve in the calcium group compared with the control group (P = .005). An increase in plasma phosphorus concentration (P = .03) was associated with calcium administration.ConclusionsIntravenous calcium supplementation to endurance horses eliminated from competition after development of metabolic problems may decrease heart rate but impairs improvement in gastrointestinal sounds.
“Recovery” in mental health services, now and then: A poststructuralist examination of the despotic State machine's effects
Authors: Johansson Jim A. , Holmes Dave 
Published: May 2023

AbstractRecovery is a model of care in (forensic) mental health settings across Western nations that aims to move past the paternalistic and punitive models of institutional care of the 20th century and toward more patient‐centered approaches. But as we argue in this paper, the recovery‐oriented services that evolved out of the early stages of this liberating movement signaled a shift in nursing practices that cannot be viewed only as improvements. In effect, as “recovery” nursing practices became more established, more codified, and more institutional(ized), a stasis developed. Recovery had been reterritorialized. The purpose of this paper is to examine some of the threads of recovery, from its early days of antipsychiatry activism to its codification into mental health—including forensic mental health—institutions through the lens of poststructuralist philosophers Gilles Deleuze and Felix Guattari. We believe that Deleuze and Guattari's scholarship provides the necessary, albeit uncomfortable, framework for this critical examination. From a conceptualization of recovery as an assemblage, we critically examine how we can go about creating something new, caught in a tension between stasis and change.
GhbZIP30‐GhCCCH17 module accelerates corm dormancy release by reducing endogenous ABA under cold storage in Gladiolus
Authors: Liang Jia‐hui , Li Jing‐ru , Liu Chang , Pan Wen‐qiang , Wu Wen‐jing , Shi Wen‐jing , Wang Lu‐jia , Yi Ming‐fang , Wu Jian 
Published: May 2023

AbstractGladiolus hybridus is one of the most popular flowers worldwide. However, its corm dormancy characteristic largely limits its off‐season production. Long‐term cold treatment (LT), which increases sugar content and reduces abscisic acid (ABA), is an efficient approach to accelerate corm dormancy release (CDR). Here, we identified a GhbZIP30‐GhCCCH17 module that mediates the antagonism between sugars and ABA during CDR. We showed that sugars promoted CDR by reducing ABA levels in Gladiolus. Our data demonstrated that GhbZIP30 transcription factor directly binds the GhCCCH17 zinc finger promoter and activates its transcription, confirmed by yeast one‐hybrid, dual‐luciferase (Dual‐LUC), chromatin immunoprecipitation‐quantitative PCR (ChIP‐qPCR) and electrophoretic mobility shift assay (EMSA). GhCCCH17 is a transcriptional activator, and its nuclear localisation is altered by surcose and cytokinin treatments. Both GhbZIP30 and GhCCCH17 positively respond to LT, sugars, and cytokinin treatments. Silencing GhbZIP30 or GhCCCH17 resulted in delayed CDR by regulating ABA metabolic genes, while their overexpression promoted CDR. Taken together, we propose that the GhbZIP30‐GhCCCH17 module is involved in cold‐ and glucose‐induced CDR by regulating ABA metabolic genes.
Translating nonviolence: Ahimsa, satyagraha, and the civil rights movement
Authors: Slate Nico 
Published: May 2023

AbstractRecent scholarship has challenged a simplistic transmission model of the diffusion of nonviolence within the American civil rights movement. Yet many historical studies remain focused on the spread of content communicated by experts and, in particular, on the relative degree to which activists adhered to what Gandhi called ahimsa, a term that is often translated as “non‐harm” or “non‐violence,” but which carried a range of meanings for Gandhi and many of his colleagues. This essay, by contrast, focuses on “satyagraha,” a word that literally means “holding firm to the truth,” and that Gandhi popularized out of frustration with the label “passive resistance.” I use a range of historical sources, including audio recordings of civil rights workshops at the Highlander Folk School, to reveal the limitations of an ahimsa‐based conception of the diffusion of nonviolence and to explore an alternative, satyagraha‐based understanding of nonviolent education within the civil rights movement. I argue that the “translation” of satyagraha played a key role in the struggle against American racism, and suggest that future scholarship should explore the centrality of translation to nonviolence as both philosophy and method.
Genome‐wide characterization of plantCTP:phosphocholine cytidylyltransferases through evolutionary, biochemical, and structural analyses
Authors: Xiao Qiong , Pan Xue , Xu Yang , Singer Stacy D. , Chen Guanqun 
Published: May 2023

SUMMARYPhosphatidylcholine has essential functions in many eukaryotic cells, and itsde novobiosynthesis is rate‐limited by cytidine triphosphate:phosphocholine cytidylyltransferase (CCT). Although the biological and biochemical functions of CCT have been reported in mammals and several plants, this key enzyme has yet to be examined at a genome‐wide level. As such, certain fundamental questions remain unanswered, including the evolutionary history, genetic and functional relationships, and structural variations among CCTs in the green lineage. In the current study, in‐depth phylogenetic analysis, as well as the conservation and diversification inCCTgene structure and motif patterns, indicated that CCTs exist broadly in chlorophytes, bryophytes, lycophytes, monilophytes, gymnosperms, early‐diverging angiosperms, monocots, and eudicots, and form eight relatively conserved clades. To further explore the potential function of selection pressure, we conducted extensive selection pressure analysis with a representativeCCTgene,CCT1from the model plantArabidopsis thaliana(AthCCT1), and identified two positive selection sites, L59 and Q156. Site‐directed mutagenesis andin vitroenzyme assays demonstrated that these positively selected sites were indeed important for the activity and substrate affinity of AthCCT1, and subsequent 3D structure analyses explained the potential biochemical mechanism. Taken together, our results unraveled the evolution and diversity of CCTs in the green lineage, as well as their association with the enzyme's biochemical and structural properties, and expanded our understanding of this important enzyme at the genome‐wide level.
THE AIMS OF TYPOLOGIES AND A TYPOLOGY OF METHODS
Authors: Chin Adam J. 
Published: May 2023

AbstractTypologies like Ian Barbour's have been widely used—and critiqued—in religion‐and‐science. Several alternatives have been proposed by, for example, John Haught, Willem Drees, Mikael Stenmark, and Shoaib Ahmed Malik. However, there has been a surprising deficit in discussion of what we wish typologies to do in religion and science in the first place. In this article, I provide a general analysis of typologies in religion‐and‐science by (1) providing a classification of existing typologies as conclusion‐ or concept‐oriented; (2) showing that typologies are used, or expected to be used, as first‐order categorizations of how religion and science are related and as second‐order classifications of scholars/scholarly works; (3) discussing several aims which we might want typologies to achieve in their second‐order usage; and (4) presenting a new kind of typology focused on the methods used by scholars which achieves those aims in a unique way.