bluuebunny/crossref_metadata_2025_split huggingface dataset:
Paradoxical embolism: a rare cause of acute upper limb ischemia
Authors: Cunha Roberto , Silva Manuel , Henrique Alberto , Maximiano Pedro , Correia Mafalda , Vieira Isabel , Cássio Isabel , Oliveira Nelson , Dias Emanuel 
Published: July 2023

Abstract
Paradoxical embolism is a rare cause of arterial embolism, even more those resulting in acute ischemia of the upper limb. A case of a 45-year-old patient with acute paradoxical upper limb embolization and acute limb ischemia is presented. A review of the most recent evidence on the diagnosis and management of paradoxical embolism were explored. The cardiac defect most associated with paradoxical embolism is a patent foramen oval. The diagnosis can be performed by transthoracic or transesophageal echocardiography. Closure of the foramen oval is a safe and effective procedure; however, there is no clear consensus on when it should be performed, so the strategy should be individualized. A high level of suspicion of paradoxical embolism should exist in the presence of simultaneous venous and arterial embolism. The investigation of the embolic source is fundamental to avoid the recurrence of events.
Polymerase chain reaction for the in vitro detection of the pESI plasmid associated with the globally circulating Salmonella Infantis outbreak strain
Authors: McMillan Elizabeth A , Hiott Lari M , Carrico Joao A , Machado Miguel P , Pouseele Hannes , Jackson Charlene R , Frye Jonathan G 
Published: July 2023

Abstract
A globally circulating strain of Salmonella enterica serotype Infantis containing the pESI plasmid has increased in prevalence in poultry meat samples and cases of human infections. In this study, a polymerase chain reaction (PCR) protocol was designed to detect the pESI plasmid and confirm the Infantis serotype of Salmonella isolates. Primers were tested bioinformatically to predict specificity, sensitivity, and precision. A total of 54 isolates of Salmonella serotypes Infantis, Senftenberg, and Alachua were tested, with and without the pESI plasmid carriage. Isolates of 31 additional serotypes were also screened to confirm specificity to Infantis. Specificity, sensitivity, and precision of each primer were &gt;0.95. All isolates tested produced the expected band sizes. This PCR protocol provides a rapid and clear result for the detection of the pESI plasmid and serotype Infantis and will allow for the in vitro detection for epidemiological studies where whole-genome sequencing is not available.
Women's Group Treatment for Substance Use Disorder
Authors: Epstein Elizabeth E. , McCrady Barbara S. 
Published: July 2023

Abstract
Women’s Group Treatment for Substance Use Disorder: Evidence-Based Cognitive Behavioral Therapy—Client Workbook is a session-by-session guide to treat the unique challenges and needs of women with alcohol and/or drug use problems. This step-by-step program is designed to help women achieve and maintain abstinence from alcohol and drugs, learn skills to prevent relapse, and achieve improvements in quality of life, self-care, coping skills, self-compassion, relationships with others, and wellness. The program also teaches skills to alleviate depression, anxiety, and trauma symptoms. Written to be used in a therapeutic setting and in conjunction with the companion Therapist Guide, the program includes easy instructions and materials to help clients identify their drinking patterns and triggers, take control of their behavior, seek social network support, understand and experience the rewards of sobriety, and find positive alternatives to drinking and drug use. Clients also will learn useful techniques for managing strong negative emotions and negative thoughts. Overcoming alcohol or drug problems is an attainable goal with this effective and comprehensive program.
A complete catalogue of broad-line AGNs and double-peaked emission lines from MaNGA integral-field spectroscopy of 10K galaxies: stellar population of AGNs, supermassive black holes, and dual AGNs
Authors: Fu Youquan , Cappellari Michele , Mao Shude , Lu Shengdong , Zhu Kai , Li Ran 
Published: July 2023

ABSTRACT
We analyse the integral field spectroscopy data for the ≈10 000 galaxies in final data release of the MaNGA survey. We identify 188 galaxies for which the emission lines cannot be described by single Gaussian components. These galaxies can be classified into (1) 38 galaxies with broad $\rm H\alpha$ and [O iii] $\rm \lambda$5007 lines, (2) 101 galaxies with broad $\rm H\alpha$ lines but no broad [O iii] $\rm \lambda$5007 lines, and (3) 49 galaxies with double-peaked narrow emission lines. Most of the broad-line galaxies are classified as active galactic nuclei (AGNs) from their line ratios. The catalogue helps us further understand the AGN-galaxy coevolution through the stellar population of broad-line region host galaxies and the relation between broad lines’ properties and the host galaxies’ dynamical properties. The stellar population properties (including mass, age, and metallicity) of broad-line host galaxies suggest there is no significant difference between narrow-line Seyfert-2 galaxies and Type-1 AGNs with broad $\rm H\alpha$ lines. We use the broad-$\rm H\alpha$ line width and luminosity to estimate masses of black hole in these galaxies, and test the MBH–σe relation in Type-1 AGN host galaxies. Furthermore, we find three dual AGN candidates supported by radio images from the VLA FIRST survey. This sample may be useful for further studies on AGN activities and feedback processes.
astraeus – VIII. A new framework for Lyman-α emitters applied to different reionization scenarios
Authors: Hutter Anne , Trebitsch Maxime , Dayal Pratika , Gottlöber Stefan , Yepes Gustavo , Legrand Laurent 
Published: July 2023

ABSTRACT
We use the astraeus framework to investigate how the visibility and spatial distribution of Lyman-α (Lyα) emitters (LAEs) during reionization is sensitive to a halo mass-dependent fraction of ionizing radiation escaping from the galactic environment (fesc) and the ionization topology. To this end, we consider the two physically plausible bracketing scenarios of fesc increasing and decreasing with rising halo mass. We derive the corresponding observed Lyα luminosities of galaxies for three different analytic Lyα line profiles and associated Lyα escape fraction ($f_\mathrm{esc}^\mathrm{Ly\alpha }$) models: importantly, we introduce two novel analytic Lyα line profile models that describe the surrounding interstellar medium (ISM) as dusty gas clumps. They are based on parameterizing results from radiative transfer simulations, with one of them relating $f_\mathrm{esc}^\mathrm{Ly\alpha }$ to fesc by assuming the ISM of being interspersed with low-density tunnels. Our key findings are: (i) for dusty gas clumps, the Lyα line profile develops from a central to double peak dominated profile as a galaxy’s halo mass increases; (ii) LAEs are galaxies with $M_h\gtrsim 10^{10}\, {\rm \rm M_\odot }$ located in overdense and highly ionized regions; (iii) for this reason, the spatial distribution of LAEs is primarily sensitive to the global ionization fraction and only weakly in second-order to the ionization topology or a halo mass-dependent fesc; (iv) furthermore, as the observed Lyα luminosity functions reflect the Lyα emission from more massive galaxies, there is a degeneracy between the fesc-dependent intrinsic Lyα luminosity and the Lyα attenuation by dust in the ISM if fesc does not exceed $\sim 50~{{\ \rm per \, cent}}$.
Relaxation of the turbulent magnetosheath
Authors: Pecora F , Yang Y , Chasapis A , Servidio S , Cuesta M E , Roy S , Chhiber R , Bandyopadhyay R , Gershman D J , Giles B L , Burch J L , Matthaeus W H 
Published: July 2023

ABSTRACTIn turbulence, non-linear terms drive energy transfer from large-scale eddies into small scales through the so-called energy cascade. Turbulence often relaxes toward states that minimize energy; typically these states are considered globally. However, turbulence can also relax toward local quasi-equilibrium states, creating patches or cells where the magnitude of non-linearity is reduced and the energy cascade is impaired. We show, using data from the Magnetospheric Multiscale (MMS) mission, and for the first time, compelling observational evidence that this ‘cellularization’ of turbulence can occur due to local relaxation in a strongly turbulent natural environment such as the Earth’s magnetosheath.
A new 2D stochastic methodology for simulating variable accretion discs: propagating fluctuations and epicyclic motion
Authors: Turner Samuel G D , Reynolds Christopher S 
Published: July 2023

ABSTRACT
Accretion occurs across a large range of scales and physical regimes. Despite this diversity in the physics, the observed properties show remarkable similarity. The theory of propagating fluctuations, in which broad-band variability within an accretion disc travel inwards and combine, has long been used to explain these phenomena. Recent numerical work has expanded on the extensive analytical literature but has been restricted to using the 1D diffusion equation for modelling the disc behaviour. In this work we present a novel numerical approach for 2D (vertically integrated), stochastically driven α-disc simulations, generalizing existing 1D models. We find that the theory of propagating fluctuations translates well to 2D. However, the presence of epicyclic motion in 2D (which cannot be captured within the diffusion equation) is shown to have an important impact on local disc dynamics. Additionally, there are suggestions that for sufficiently thin discs the log-normality of the light curves changes. As in previous work, we find that the break frequency in the luminosity power spectrum is strongly dependent on the driving time-scale of the stochastic perturbations within the disc, providing a possible observational signature for probing the magnetorotational instability dynamo. We also find that thinner discs are significantly less variable than thicker ones, providing a compelling explanation for the greater variability seen in the hard state versus the soft state of X-ray binaries. Finally, we consider the wide-ranging applications of our numerical model for use in other simulations.
Cosmic web dissection in fuzzy dark matter cosmologies
Authors: Dome Tibor , Fialkov Anastasia , Sartorio Nina , Mocz Philip 
Published: July 2023

ABSTRACT
On large cosmological scales, anisotropic gravitational collapse is manifest in the dark cosmic web. Its statistical properties are little known for alternative dark matter (DM) models such as fuzzy dark matter (FDM). In this work, we assess for the first time the relative importance of cosmic nodes, filaments, walls, and voids in a cosmology with primordial small-scale suppression of power. We post-process N-body simulations of FDM-like cosmologies with varying axion mass m at redshifts z ∼ 1.0−5.6 using the NEXUS+ Multiscale Morphology Filter technique at smoothing scale Δx = 0.04 h−1 Mpc. The formation of wall and void halos is more suppressed than naively expected from the half-mode mass M1/2. Also, we quantify the mass- and volume-filling fractions of cosmic environments and find that 2D cosmic sheets host a larger share of the matter content of the Universe as m is reduced, with an ∼8−12 per cent increase for the m = 7 × 10−22 eV model compared to cold dark matter (CDM). We show that in FDM-like cosmologies, filaments, walls, and voids are cleaner and more pronounced structures than in CDM, revealed by a strong mid-range peak in the conditioned overdensity PDFs P(δ). At high redshift, low-density regions are more suppressed than high-density regions. Furthermore, skewness estimates S3 of the total overdensity PDF in FDM-like cosmologies are consistently higher than in CDM, especially at high redshift z ∼ 5.6 where the m = 10−22 eV model differs from CDM by ∼6σ. Accordingly, we advocate for the usage of P(δ) as a testbed for constraining FDM and other alternative DM models.
The first evidence of tidally induced activity in a brown dwarf-M dwarf pair: a Chandra study of the NLTT 41135/41136 system
Authors: Ilić Nikoleta , Poppenhaeger Katja , Dsouza Desmond , Wolk Scott J , Agüeros Marcel A , Stelzer Beate 
Published: July 2023

ABSTRACT
The magnetic activity of low-mass stars changes as they age. The primary process decreasing the stellar activity level is the angular momentum loss via magnetized stellar wind. However, processes like tidal interactions between stars and their close companions may slow down the braking effect and the subsequent decrease of the activity level. Until now, the tidal impact of substellar objects like brown dwarfs on the evolution of their central stars has not been quantified. Here, we analyse the X-ray properties of NLTT 41135, an M dwarf tightly orbited by a brown dwarf, to determine the impact of tidal interactions between them. We find that NLTT 41135 is more than an order of magnitude brighter in the X-ray regime than its stellar companion, NLTT 41136, also an M dwarf star, with whom it forms a wide binary system. To characterize the typical intrinsic activity scatter between coeval M dwarf stars, we analyse a control sample of 25 M dwarf wide binary systems observed with the XMM–Newton and Chandra telescopes and the eROSITA instrument onboard the Spectrum Röntgen Gamma satellite. The activity difference in the NLTT 41135/41136 system is a 3.44σ outlier compared to the intrinsic activity scatter of the control systems. Therefore, the most convincing explanation for the observed activity discrepancy is tidal interactions between the M dwarf and its brown dwarf. This shows that tidal interactions between a star and a substellar companion can moderately alter the expected angular-momentum evolution of the star, making standard observational proxies for its age, such as X-ray emission, unreliable.
Breaking the τT–f degeneracy of the kinetic Sunyaev–Zel’dovich cosmology in redshift space
Authors: Xiao Liang , Zheng Yi 
Published: July 2023

ABSTRACT
The ‘optical depth–linear growth rate’ (τT − f) degeneracy is a long-standing problem in the kinetic Sunyaev–Zel’dovich (kSZ) cosmology. It can be broken in redshift space, where the velocity field leaves its own distinct imprint on the galaxies’ redshift space positions and provides valuable information of the linear growth rate. We validate this idea with the Fisher matrix and Monte Carlo Markov chain techniques in this work, finding that the level of this degeneracy breaking is further enhanced on non-linear scales due to the non-linear evolution of the density and velocity fields, if we have a good prior knowledge of the non-linear bias of galaxies. This result emphasizes the importance of the redshift space analysis of the kSZ effect and its potential as a powerful cosmological probe, especially on non-linear scales. As a by-product, we develop a non-linear model of the redshift space density-weighted pairwise kSZ power spectrum. The fitted f and τT values from this model are shown to be accurate within 1σ–2σ ranges of the fiducial ones when confronted to the mock galaxies mimicking a DESI + CMB-S4 survey combination, even on small scales of k ∼ 0.5h Mpc−1.
The nature of the X-ray sources in dwarf galaxies in nearby clusters from the KIWICS
Authors: Şen Şeyda , Göğüş Ersin , Peletier Reynier F , Choque-Challapa Nelvy , Amiri Amirnezam 
Published: July 2023

ABSTRACT
We present a deep search for and analysis of X-ray sources in a sample of dwarf galaxies (Mr &lt; −15.5 mag) located within twelve galaxy clusters from the Kapteyn IAC WHT Enhanced Area Velocity Explores Isaac Newton Telescope Cluster Survey of photometric observations in the r and g using the Wide Field Camera at the 2.5-m Isaac Newton telescope. We first investigated the optical data, identified 2720 dwarf galaxies in all fields and determined their characteristics; namely, their colours, effective radii, and stellar masses. We then searched the Chandra data archive for X-ray counterparts of optically detected dwarf galaxies. We found a total of 20 X-ray emitting dwarf galaxies, with X-ray flux ranging from 1.7 × 10−15 to 4.1 × 10−14 erg cm−2 s−1 and X-ray luminosities varying from 2 × 1039 to 5.4 × 1041 erg s−1. Our results indicate that the X-ray luminosity of the sources in our sample is larger than the Eddington luminosity limit for a typical neutron star, even at the lowest observed levels. This leads us to conclude that the sources emitting X-rays in our sample are likely black holes. Additionally, we have employed a scaling relation between black hole and stellar mass to estimate the masses of the black holes in our sample, and have determined a range of black hole masses from 4.6 × 104 to 1.5 × 106 M⊙. Finally, we find a trend between X-ray to optical flux ratio and X-ray flux. We discuss the implications of our findings and highlight the importance of X-ray observations in studying the properties of dwarf galaxies.
Wave modes and instabilities in gravitating magnetized polytropic quantum plasmas including viscosity tensor and FLR corrections
Authors: Sangwan Vinesh Kumar , Prajapati Ram Prasad 
Published: July 2023

ABSTRACT
The present analytical study extends the problems of pressure anisotropy-driven instabilities and gravitational instability in space plasmas to mixed quantum polytropic gas in the interior of dense stars accounting for the effects of viscosity, finite Larmor radius (FLR) and self-gravitational effects. The generalized polytrope pressure laws are considered as adiabatic equations in which the pressure components depend upon the plasma density, magnitude of the magnetic field, and the polytrope indices. The modified properties of waves and instabilities in gravitating quantum plasmas have been analysed using the quantum magnetohydrodynamic (QMHD) fluid description in the magnetohydrodynamic (MHD) and Chew–Goldberger–Low (CGL) limits. In the parallel propagation, the Jeans instability modified by quantum diffraction parameters and firehose mode modified by FLR parameter is obtained separately. The Jeans instability condition depends upon the quantum diffraction term and polytrope index β, and it remains unaffected due to viscosity and ion Larmor frequency. The growth rate of the Jeans instability decreases due to viscosity and quantum diffraction parameters, while the growth rate of the firehose instability increases due to FLR corrections. In the transverse mode, a similar nature is observed in the growth rates; however, the instability region decreases significantly due to polytrope indices and different dispersion properties of MHD and CGL viscous quantum plasmas. The analytical results have been applied in dense degenerate stars to measure the characteristic parameters and understand the MHD wave propagation, pressure anisotropy-driven, and gravitationally driven instabilities.
Co-Evolution vs. Co-existence: The effect of accretion modelling on the evolution of black holes and host galaxies
Authors: Soliman Nadine H , Macciò Andrea V , Blank Marvin 
Published: July 2023

ABSTRACT
We append two additional black hole (BH) accretion models, namely viscous disc and gravitational torque-driven accretion, into the Numerical Investigation of a Hundred Astrophysical Objects (NIHAO) project of galaxy simulations. We show that these accretion models, characterized by a weaker dependence on the BH mass compared to the commonly used Bondi-Hoyle accretion, naturally create a common evolutionary track (co-existence) between the mass of the BH and the stellar mass of the galaxy, even without any direct coupling via feedback (FB). While FB is indeed required to control the final BH and stellar mass of the galaxies, our results suggest that FB might not be the leading driver of the cosmic co-evolution between these two quantities; in these models, co-evolution is simply determined by the shared central gas supply. Conversely, simulations using Bondi-Hoyle accretion show a two-step evolution, with an early growth of stellar mass followed by exponential growth of the central supermassive black hole (SMBH). Our results show that the modelling of BH accretion (sometimes overlooked) is an extremely important part of BH evolution and can improve our understanding of how scaling relations emerge and evolve, and whether SMBH and stellar mass co-exist or co-evolve through cosmic time.
Human serum albumin as a copper source for anticancer thiosemicarbazones
Authors: Schaier Martin , Falcone Enrico , Prstek Tomas , Vileno Bertrand , Hager Sonja , Keppler Bernhard K , Heffeter Petra , Koellensperger Gunda , Faller Peter , Kowol Christian R 
Published: July 2023

Abstract
Thiosemicarbazones (TSCs) are a class of biologically active compounds with promising anticancer activity. Their typical mechanism, especially of the clinically far developed representative Triapine, is chelation of iron (Fe), with the Fe-containing enzyme ribonucleotide reductase as primary intracellular target. However, for the subclass of terminally disubstituted, nanomolar-active derivatives like Dp44mT and Me2NNMe2, recent findings suggest that the chelation, stability, and reduction properties of the copper(II) (Cu) complexes are essential for their modes of action. Consequently, it is important to elucidate whether blood serum Cu(II) is a potential metal source for these TSCs. To gain more insights, the interaction of Triapine, Dp44mT or Me2NNMe2 with purified human serum albumin (HSA) as the main pool of labile Cu(II) was investigated by UV-vis and electron paramagnetic resonance measurements. Subsequently, a size-exclusion chromatography inductively coupled plasma mass spectrometry method for the differentiation of Cu species in serum was developed, especially separating the non-labile Cu enzyme ceruloplasmin from HSA. The results indicate that the TSCs specifically chelate copper from the N-terminal Cu-binding site of HSA. Furthermore, the Cu(II)-TSC complexes were shown to form ternary HSA conjugates, most likely via histidine. Noteworthy, Fe-chelation from transferrin was not overserved, even not for Triapine. In summary, the labile Cu pool of HSA is a potential source for Cu-TSC complex formation and, consequently, distinctly influences the anticancer activity and pharmacological behavior of TSCs.
Evolution of molecular switches for regulation of transgene expression by clinically licensed gluconate
Authors: Teixeira Ana Palma , Xue Shuai , Huang Jinbo , Fussenegger Martin 
Published: July 2023

Abstract
Synthetic biology holds great promise to improve the safety and efficacy of future gene and engineered cell therapies by providing new means of endogenous or exogenous control of the embedded therapeutic programs. Here, we focused on gluconate as a clinically licensed small-molecule inducer and engineered gluconate-sensitive molecular switches to regulate transgene expression in human cell cultures and in mice. Several switch designs were assembled based on the gluconate-responsive transcriptional repressor GntR from Escherichia coli. Initially we assembled OFF- and ON-type switches by rewiring the native gluconate-dependent binding of GntR to target DNA sequences in mammalian cells. Then, we utilized the ability of GntR to dimerize in the presence of gluconate to activate gene expression from a split transcriptional activator. By means of random mutagenesis of GntR combined with phenotypic screening, we identified variants that significantly enhanced the functionality of the genetic devices, enabling the construction of robust two-input logic gates. We also demonstrated the potential utility of the synthetic switch in two in vivo settings, one employing implantation of alginate-encapsulated engineered cells and the other involving modification of host cells by DNA delivery. Then, as proof-of-concept, the gluconate-actuated genetic switch was connected to insulin secretion, and the components encoding gluconate-induced insulin production were introduced into type-1 diabetic mice as naked DNA via hydrodynamic tail vein injection. Normoglycemia was restored, thereby showcasing the suitability of oral gluconate to regulate in situ production of a therapeutic protein.