bluuebunny/crossref_metadata_2025_split huggingface dataset:
Urological training during the COVID-19 pandemic: Our Initial Experience of TURP simulator in Singapore Residency Training and its increasing relevance for surgical skills training
Authors: Lim Ee Jean , Gan Valerie Huei Li , Ong Julene Hui Wun , Foo Malia Alexandra , Fong Khi Yung , Sim Allen , Ho Henry Sun Sien , Lau Weber Kam On , Ong Caroline Choo Phaik , Aslim Edwin Jonathan , Gauhar Vineet , Yuen John Shyi Peng , Chen Kenneth 
Published: June 2023

Abstract
Purpose: Urological training in Singapore has seen a reduction in length of training and shortened working hours to fit requirements of the residency model. Virtual reality(VR) simulators may contribute as an adjunct to shorten the learning curve and acquire surgical skills. This study assesses the construct validity of a transurethral resection of prostate(TURP) simulator and its pilot study in urological residents.
Methods: The study first assessed the construct validity of the VirtaMed UroS™️ simulator with 12 novices and 12 experts. A pilot study involving 12 junior(JR) and 15 senior urology residents(SR) was then conducted. Participants were given 2 attempts to complete the same task. Performance indicators include: Percentage of prostate resected(PR), Completion time, the time that loop diathermy was active without tissue contact(TAWC), percentage of capsule resection(CR).
Results: Construct validity was demonstrated: experts had significantly greater PR (40.6% vs 11.9%, p<0.05) and less TAWC than novices (0.13s vs 13.9s, p<0.05). JR demonstrated an increase in PR (13.3% vs 26.7%, p=0.0005) and a decrease in TAWC when comparing attempts (4.5s vs 1.3s, p= 0.003). Although statistically insignificant, increased PR (30.2 vs 40.5, p=0.1) and decreased TAWC (1.1 vs 0.9, p=0.84) was demonstrated when comparing attempts by SR. In the 2nd attempt, both groups demonstrated a decrease in TAWC with JR showing a greater decrease (2.9 vs 0.4, p<0.05).
Conclusion: This pilot experience shows that the TURP simulator may provide time-efficient learning to supplement urological training. Further research and incorporation of VR simulation is needed to develop more robust and comprehensive training programmes.
An auto-scaling approach for microservices in cloud computing environments
Authors: ZargarAzad Matineh , Ashtiani Mehrdad 
Published: June 2023

Abstract
Today, web applications are one of the most common applications providing service to users. Web application providers have moved their applications to cloud data centers. In this regard, microservices have become a famous architecture for building cloud-native applications. Cloud computing provides flexibility for service providers, allowing them to remove or add resources depending on the workload of their web applications. If the resources allocated to the service are not aligned with its requirements, failure or delayed response will increase, resulting in customer dissatisfaction. This problem has become a significant challenge in microservices-based applications because thousands of microservices in the system may have complex interactions. Auto-scaling is a feature of cloud computing that enables resource scalability on demand. This allows service providers to deliver resources to their applications without human intervention under a dynamic workload to minimize resource cost and latency while maintaining the Quality of Service (QoS) requirements. In this research, we aimed to establish a computational model for analyzing the workload of all microservices. This is performed by considering the overall workload entered into the system and taking into account the relationships and call functions between microservices. This is because, in a large-scale application with thousands of microservices, it is usually difficult to accurately monitor all the microservices and gather precise performance metrics. Then, we introduce a multi-criteria decision-making method to select candidate microservices for scaling. The results of the conducted experiments show that the detection of input load toward microservices is performed with an average accuracy of 99% which is a significant value. Also, the proposed approach improves the maximum use of resources by an average of 22.73%, reducing the number of scaling times by 69.82%, and finally reducing the number of required resources which also affects the cost by 1.67% compared to existing approaches.
Investigation of morphology and catalytic behaviour of vanadyl ions embedded in ammonium heptamolybdate as efficient nanocomposite catalyst for epoxidation of allyl alcohols
Authors: Farzaneh Faezeh , Yeroushalmi Rebecca , Azarkamanzad Zahra 
Published: June 2023

Abstract
In this study nano composites using vanadyl sulfate and ammonium heptamolybdate were synthesized under reflux conditions. The obtained results indicated that the ratio of starting materials as well as reaction condition (reflux) have an important role in the morphology of the prepared composites. The prepared composites were characterised using FT-IR, SEM, EDX, XRD, ICP and TGA techniques. Then, it was found that the prepared composites successfully catalyze the epoxidation of allyl alcohols with tert-buthylhydroperoxide (TBHP) in high yields. The epoxidation of geraniol, trans − 2-hexene-1-ol, 1-octene- 3-ol and 3-methyl-2-butene-1-ol with 100% selectivity is promising. stability, reusability and high efficiency of composites are the advantages of these composites.
Designing Subgrade for Flexible Pavement in Bottom Ash, Lime and Sodium Hexametaphosphate Stabilized Expansive Soil
Authors: Rana Shiwani , Singh Sandeep , Sharma Abhishek 
Published: June 2023

Abstract
The current study examines the effective use of wastes, bottom ash which is mixed with lime and sodium hexametaphosphate (NAPO3)6, to stabilize the expansive soil in order to make a composite subgrade material for flexible pavement design. The study involves performing laboratory tests on expansive soil samples containing bottom ash and lime alone and along with (NAPO3)6, such as differential free swell, consistency limits, compaction characteristics, unconfined compressive strength tests and California bearing ratio. The results showed that adding an optimal amount of bottom ash (15%), lime (6%), and (NAPO3)6 (4.5%), both alone and in combination, reduces the differential free swell and consistency limits of expansive soil and increased the CBR values, accomplishing it into an effective subgrade material. The thickness of flexible pavement was designed using IITPAVE software by utilising the obtained CBR values, it met the required parameters based on the IRC: 37-2018 recommendations. The software analysis revealed a reduction in pavement thickness for different commercial vehicle traffic volumes (1000, 2000, and 5000), with the highest reduction in layer thickness and construction costs observed when expansive soil was combined with bottom ash (15%), lime (6%), and (NAPO3)6 (4.5%). This technology not only improves the geotechnical characteristics of subgrade soil, but it is also cost-effective and tackles the bottom ash disposal issue. Overall, this research proposes a novel method for developing a composite soil subgrade material for flexible pavement.
Future sexual dysfunctions of hypospadias patients who was operated in childhood
Authors: Kılıç Sinan , Verep Samed 
Published: June 2023

Abstract
Background: Hypospadias is a congenital anomaly that can be seen in every 300 male births and may cause sexual dysfunction in the future. Aim: This study focused on the possible future sexual dysfunction of children who were diagnosed with hypospadias and experienced treatment processes.
Methods: Thirty male patients who were diagnosed with Hypospadias and completed the treatment process between November 2022 and March 2023 were included in the prospective study. Patients' age, BMI, and age of the patient at the surgery were recorded. Sexual functions were assessed with the Arizona Sexual Experiences Scale (ASEX). Outcomes: Sexual dysfunctions were found to be significantly higher in individuals who had undergone hypospadias surgery.
Results: Patients with hypospadias diagnosed and operated in childhood, the mean age was 27.2±4.6, BMI was 24.8±1.6, and the time to diagnosis of hypospadias was 3.8±0.9. Although 55% of the patients in the study were single, 45% were married.
Clinical Implications: In the first clinical examination after hypospadias surgery, it is checked whether there is an aesthetically correct penis and meatus, and whether the child is voiding properly. A child who has an aesthetically good penis and can urinate in the right size and in the right direction is considered successful. Sexual dysfunctions are longer-term consequences. We observed that these sprains were more than expected after hypospadias surgery. Long-term follow-up of patients who have undergone hypospadias surgery, especially proximal repair, should be done closely.
Strengths & Limitations: Streng The limitation of the study is the small number of patients who applied to the clinic as a result of all patients who developed sexual dysfunction after hypospadias surgery. The second limitation is the tendency to hide sexual problems experienced.ths & Limitations.
Conclusion: As a result of the study, it was concluded that the sexual dysfunction of the patients was more severe than expected.
A new bird calicivirus detected in feces of cormorant
Authors: Wang Yan , Zhao Ran , Sun Yijie , Wu Yan , Ji Likai , He Yuyun , Hou Jingjing , Qin Zhaoying , Yang Shixing , Zhang Wen 
Published: June 2023

Abstract
The incidence of reporting caliciviruses in wild birds is less common than in other animals, and the majority of cases remain unclassified. A strain of calicivirus was discovered in this study in the feces of cormorants collected at Xiamen Horticulture Expo Garden in 2021 and was named Cormcali01. The genome of Cormcali01 was 8,561 bp in length which contained characteristic motifs present in other caliciviruses. Furthermore, it showed significant divergence from all available calicivirus nucleotide sequences, with the highest similarity to the unclassified Ruddy turnstone calicivirus A (47.34%). Pairwise comparison of the VP1 protein showed that Cormcali01 had the highest amino acid identity of 43.90% with the unassigned Ruddy turnstone calicivirus A. Phylogenetic analysis demonstrated that VP1 of Cormcali01 clustered with unassigned caliciviruses. Therefore, based on phylogenetic analysis and pairwise comparison, Cormcali01 should be affiliated with the unassigned calicivirus, which were suggested to comprise a new calicivirus genus, the Sanovirus genus. After investigating the prevalence of Cormcali01, we discovered that 22.22% of fecal samples (10/45) were tested positive. These findings expanded our understanding of the genetic variation of caliciviruses and provided valuable epidemiological information regarding a potential outbreak of calicivirus disease in birds.
DDX5 enhances proliferation and metastasis of Head and Neck Squamous Cell Carcinoma via β-Catenin signaling pathway activations
Authors: Chen Qi , Ji Yingying , Zheng Xiaoying , Sheng Jiying , Ren Qiang , Wei Kuijie 
Published: June 2023

Abstract
Head and neck squamous cell carcinoma (HNSCC) is extremely challenged to undergo sNurgeries and the underlying mechanisms behind it remain unclear. We evaluated whether DDX5 functions indispensably in HNSCC prognosis and found that DDX5 is up-regulated among HNSCC samples and overexpression enhances HNSCC. The β-catenin signaling pathway activation with the DDX5 assistance promotes HNSCC in vitro. Targeting β-catenin signaling pathway utilizing MSAB as inhibitor successfully ameliorates HNSCC in subcutaneous injection mouse model in vivo as well as malignant functions in vitro. Our findings elucidate that DDX5 might function as an oncogenic biomarker for HNSCC, which could be a candidate target in clinical therapies.
Circling the Void: Using Heidegger and Lacan to think about Large Language Models
Authors: Heimann Marc , Hübener Anne-Friederike 
Published: June 2023

Abstract
This essay bridges two disparate lines of inquiry: Large Language Models (LLMs) and continental philosophy, specifically Martin Heidegger's reflections on language and Jacques Lacan's structural psychoanalysis grounded in Sigmund Freud's theories. We argue that the linguistic conceptualizations put forth by Heidegger, Freud, and Lacan, primarily employed in clinical frameworks, find surprising resonance in the operations of modern LLMs. This parallel allows us to bring into focus a central theme of continental discourse—negation and negativity—largely absent in current LLM research. Our approach diverges radically from conventional philosophy of artificial intelligence, which primarily engages with analytic philosophy. Here, we build our discourse on thinkers often overlooked in this field, delineating the ontological differences of our approach. Our goal is to foster a dialogue between AI researchers and continental philosophers, highlighting the mutual insights that these two distinct perspectives can offer.
Harnessing Fe 2 O 3 to Improve HAP Composites: Investigating Radiation Shielding, Mechanical Attributes, and Magnetic Field Effects
Authors: Malidarre Roya Boodaghi , Akkurt Iskender , Zakaly Hesham M.H. , Korkmaz Abdul Vahap , Ekmekci Ismail 
Published: June 2023

Abstract
Hydroxyapatite (HAP) bio-composites are widely utilized for the repair and replacement of bone and teeth tissues in humans. However, due to their suboptimal mechanical properties, the strength and durability of pure HAP have been improved by incorporating various alloys and materials. This study examines the radiation shielding and mechanical properties of Fe2O3-reinforced HAP composites for use as implants, with Fe2O3 concentrations of 0.0, 2.5, 5.0, and 7.5 wt.%. The study also investigates the composite's behavior in a magnetic field. Using the FLUKA Monte Carlo Code, radiation shielding factors are determined, and the mechanical properties of the composites are assessed through theoretical methods. Results indicate that increasing Fe2O3 content in HAP bio-composites enhances the radiation shielding and mechanical properties of the selected samples. Additionally, without a magnetic field, particle distribution displays symmetry along the x-axis; however, when exposed to a magnetic field of Bx=5 microT, a distinct pattern emerges.
Evaluation of vaccine efficacy and snail control on the transmissionof Schistosoma Haematobium in Communities around the Volta Lake in Ghana
Authors: Agana Francis , Obeng-Forson Ferdinard , Ohene-Ayeh William , Armah-Agyeman Emmanuel 
Published: June 2023

Abstract
Following some successes recorded in recent clinical trials of vaccine in mice and rodentsof a Schistosomiases also known as the snail fever, we present in this work a mathematicalmodel to assess the potential impact of vaccine discovery on the spread of the disease incommunities around the Volta lake in Ghana, West Africa. We present also the efficacy ofa hybrid method that involves the combination of vaccine administration and an age oldpractice of controlling the population in schistosomiasis prone areas as a control strategyagainst the disease.
Economic Impact of Soil Losses in Pineapple Crops (Ananas Comosus L. Merr) In the Valle Del Cauca, Colombia
Authors: López Carolina Martínez , Flores Juan Carlos Menjívar , Muñoz Luis Fernando Delgado 
Published: June 2023

Abstract
Soil erosion generates nutrient and crop yield losses and environmental and economic impacts. The research evaluated the economic impact of soil and nutrient losses in pineapple cultivation in the department of Valle del Cauca, Colombia. A total of nine runoff plots were established in the main producing municipalities, where the evaluation was carried out during two complete rainy periods (2019–2020). Subsequently, the loss of soil as well as nutrients (N, P, K, Ca, Mg, B, Mn, Cu, Zn, Fe ) was calculated, and its economic value was determined by the replacement cost method. Losses of clay and organic matter were included in the analysis. Soil losses varied from 40 to 261 t/ha/year, which corresponds to moderate to very high degrees of erosion, with Dagua being the most affected municipality. It was found that among the farms that showed the greatest losses of nutrients, the most affected were potassium, iron, and manganese with values of up to 535 kg/ha, 330 kg/ha, and 177 kg/ha, respectively; however, at a general level, the main losses occurred for potassium and nitrogen. Finally, the economic losses ranged from US$ 1266.15 to more than US$ 5908.70 per plot, representing losses of up to US$ 14367177.80 for the total area planted with pineapple, which implies serious economic repercussions for farmers in the region.
Climate change effects on soil salinity in rainfed maize areas: a case study from South Africa
Authors: Haj-Amor Zied , Araya Tesfay , Kim Dong-Gill , Bouri Salem 
Published: June 2023

AbstractIn maize fields, few studies have been conducted to identify the temporal trend of soil salinity and formulate optimal irrigation plans under climate change. Therefore, the main goals of this study were to predict changes in soil salinity over 2022–2050 and to formulate an optimal supplemental irrigation plan preventing soil salinity in a South African rainfed maize field. The study used the Global Climate Model (GCM) MPI-ESM1-2-LR to obtain future climate data for the study area from 2022 to 2050 and applied the HYDRUS-1D model to project the effects of these future climate data on soil salinity over the same period and to identify the best irrigation plan under climate change. Two key findings were revealed: first, the combined use of GCMs (i.e., MPI-ESM1-2-LR model) and soil-water models (i.e., HYDRUS-1D) was a powerful tool to identify soil salinity trends and formulate optimal irrigation plan under climate change. Second, in addition to rainfall amount, supplying a limited supplemental irrigation amount equal to 8% of the actual evapotranspiration of maize at the mid-season stage of maize growth can significantly reduce soil salinity (&lt;1.7 dS m−1) and enhance soil moisture under climate change by 2050. These findings will be useful for preventing soil salinity in rainfed maize fields.
Identification of a Novel Diagnosis Model based on 5 Hub Genes for
Chronic Thromboembolic Pulmonary Hypertension
Authors: Zhang Feng , Huang Xiaoming , Lin Junqi , Yu Ruilin , Lin Shaoming , Shen Guanle , Chen Wenbiao 
Published: June 2023

Background:
As a type of precapillary pulmonary hypertension, chronic
thromboembolic pulmonary hypertension (CTEPH) results from incomplete pulmonary
embolism resolution. In this study, we aimed to determine biomarker genes for predicting
the prognosis of CTEPH.

Methods:
RNAseq of CTEPH was collected from the public database, namely Gene Expression
Omnibus (GEO), including GSE84538 and GSE188938, which combined a dataset
(GSE). Differentially expressed genes (DEG) or miRNA (DEM) were identified by
limma package. Functional enrichment analysis was performed by the WebGestaltR package.
Then, the miRNA-mRNA network was presented by Cytoscape, and the protein-protein
interactions (PPI) network was constructed by STRING. MCODE was mined by mature
MCODE algorithm. Immune infiltration analysis was conducted by ESTIMATER
and ssGSEA analysis. A diagnosis model was established by SVM algorithm.

Results:
In the GSE dataset, CTEPH samples had a lower GOBP_RESPONSE_-
TO_OXIDATIVE_STRESS score. A total of 628 DEGs and 31 DEMs were identified between
CTEPH and normal samples. Afterward, DEGs were intersected with genes,
which correlated with the GOBP_RESPONSE_TO_OXIDATIVE_STRESS score. A 26
DEMs-152 DEGs network was constructed, and a PPI network was established based on
152 DEGs to find 149 target genes. From the above 149 target genes, 3 modules were extracted
to obtain 15 core targets. Finally, 5 hub genes were obtained by the intersection
of 15 core targets and genes in MCODE2. A total of 5 hub genes were positively correlated
with most immune cell scores as well as GOBP_RESPONSE_TO_OXIDATIVE_
STRESS. It was found that a diagnosis model based on 5 hub genes had a well diagnostic
ability for CTEPH.

Conclusion:
We identified 5 hub genes associated with oxidative stress. It can be concluded
that they may be beneficial in diagnosing CTEPH.
Benefits of Manuka Honey in the Management of Infectious Diseases:
Recent Advances and Prospects
Authors: Sinha Shweta , Sehgal Alka , Ray Sudip , Sehgal Rakesh 
Published: June 2023

Abstract:
The benefits of honey have been recognized since ancient times for treating numerous
diseases. However, in today's modern era, the use of traditional remedies has been rapidly
diminishing due to the complexities of modern lifestyles. While antibiotics are commonly used and
effective in treating pathogenic infections, their inappropriate use can lead to the development of
resistance among microorganisms, resulting in their widespread prevalence. Therefore, new
approaches are constantly required to combat drug-resistant microorganisms, and one practical and
useful approach is the use of drug combination treatments.

:
Manuka honey, derived from the manuka tree (Leptospermum scoparium) found exclusively in New
Zealand, has garnered significant attention for its biological potential, particularly due to its
antioxidant and antimicrobial properties. Moreover, when combined with antibiotics, it has
demonstrated the ability to enhance their effectiveness. In this review, we delve into the chemical
markers of manuka honey that are currently known, as well as detail the impact of manuka honey on
the management of infectious diseases up to the present.
A Review on Solid Lipid Nanoparticles as Nano Drug Delivery
Transporters
Authors: More Smita D. , Wadhokar Anjali S. , Bedjawalge Rushali S. 
Published: June 2023

Abstract:
Solid lipid nanoparticles (SLN) have several potential uses in research for medicine such
as drug discovery and drug delivery, an area at the forefront of evolving area of nanobiotechnology.
In general, SLNs were created to address the drawbacks of conventional colloidal carriers, including
emulsions, liposomes, and polymeric nanoparticles since they provide various advantages such
as favourable release profiles and tailored drug delivery with outstanding physical-chemical stability.
Solid lipid nanoparticles are spherical solid lipid particles that are distributed in water or an
aqueous surfactant solution and are in the nanometer size range. Therefore, SLN is used to deliver
hydrophilic and lipophilic drugs. The review article focuses on various aspects of SLN including the
structure, the influence of excipients, the drug incorporation model, the principle of release, the
method of preparation, characterization, the route of administration and biodistribution, and the application
of SLN.