bluuebunny/crossref_metadata_2025_split huggingface dataset:
Liver‐Inspired Polyetherketoneketone Scaffolds Simulate Regenerative Signals and Mobilize Anti‐Inflammatory Reserves to Reprogram Macrophage Metabolism for Boosted Osteoporotic Osseointegration
Authors: Gu Hao , Zhu Yuhui , Yang Jiawei , Jiang Ruixue , Deng Yuwei , Li Anshuo , Fang Yingjing , Wu Qianju , Tu Honghuan , Chang Haishuang , Wen Jin , Jiang Xinquan 
Published: July 2023

AbstractTissue regeneration is regulated by morphological clues of implants in bone defect repair. Engineered morphology can boost regenerative biocascades that conquer challenges such as material bioinertness and pathological microenvironments. Herein, a correlation between the liver extracellular skeleton morphology and the regenerative signaling, namely hepatocyte growth factor receptor (MET), is found to explain the mystery of rapid liver regeneration. Inspired by this unique structure, a biomimetic morphology is prepared on polyetherketoneketone (PEKK) via femtosecond laser etching and sulfonation. The morphology reproduces MET signaling in macrophages, causing positive immunoregulation and optimized osteogenesis. Moreover, the morphological clue activates an anti‐inflammatory reserve (arginase‐2) to translocate retrogradely from mitochondria to the cytoplasm due to the difference in spatial binding of heat shock protein 70. This translocation enhances oxidative respiration and complex II activity, reprogramming the metabolism of energy and arginine. The importance of MET signaling and arginase‐2 in the anti‐inflammatory repair of biomimetic scaffolds is also verified via chemical inhibition and gene knockout. Altogether, this study not only provides a novel biomimetic scaffold for osteoporotic bone defect repair that can simulate regenerative signals, but also reveals the significance and feasibility of strategies to mobilize anti‐inflammatory reserves in bone regeneration.
Record‐High Ultrasound‐Sensitive NO Nanogenerators for Cascade Tumor Pyroptosis and Immunotherapy
Authors: Bao Yuheng , Ge Yanni , Wu Mengjie , Mao Zhengwei , Ye Juan , Tong Weijun 
Published: July 2023

AbstractPyroptosis is a pro‐inflammatory cell death that is associated with innate immunity promotion against tumors. Excess nitric oxide (NO)‐triggered nitric stress has potential to induce pyroptosis, but the precise delivery of NO is challenging. Ultrasound (US)‐responsive NO production has dominant priority due to its deep penetration, low side effects, noninvasion, and local activation manner. In this work, US‐sensitive NO donor N‐methyl‐N‐nitrosoaniline (NMA) with thermodynamically favorable structure is selected and loaded into hyaluronic acid (HA)‐modified hollow manganese dioxide nanoparticles (hMnO2 NPs) to fabricate hMnO2@HA@NMA (MHN) nanogenerators (NGs). The obtained NGs have a record‐high NO generation efficiency under US irradiation and can release Mn2+ after targeting the tumor sites. Later on, cascade tumor pyroptosis and cyclic GMP‐AMP synthase‐stimulator of interferon genes (cGAS‐STING)‐based immunotherapy is achieved and tumor growth is effectively inhibited.
Tissue‐Engineered Disease Modeling of Lymphangioleiomyomatosis Exposes a Therapeutic Vulnerability to HDAC Inhibition
Authors: Pietrobon Adam , Yockell‐Lelièvre Julien , Melong Nicole , Smith Laura J. , Delaney Sean P. , Azzam Nadine , Xue Chang , Merwin Nishanth , Lian Eric , Camacho‐Magallanes Alberto , Doré Carole , Musso Gabriel , Julian Lisa M. , Kristof Arnold S. , Tam Roger Y. , Berman Jason N. , Shoichet Molly S. , Stanford William L. 
Published: July 2023

AbstractLymphangioleiomyomatosis (LAM) is a rare disease involving cystic lung destruction by invasive LAM cells. These cells harbor loss‐of‐function mutations in TSC2, conferring hyperactive mTORC1 signaling. Here, tissue engineering tools are employed to model LAM and identify new therapeutic candidates. Biomimetic hydrogel culture of LAM cells is found to recapitulate the molecular and phenotypic characteristics of human disease more faithfully than culture on plastic. A 3D drug screen is conducted, identifying histone deacetylase (HDAC) inhibitors as anti‐invasive agents that are also selectively cytotoxic toward TSC2−/− cells. The anti‐invasive effects of HDAC inhibitors are independent of genotype, while selective cell death is mTORC1‐dependent and mediated by apoptosis. Genotype‐selective cytotoxicity is seen exclusively in hydrogel culture due to potentiated differential mTORC1 signaling, a feature that is abrogated in cell culture on plastic. Importantly, HDAC inhibitors block invasion and selectively eradicate LAM cells in vivo in zebrafish xenografts. These findings demonstrate that tissue‐engineered disease modeling exposes a physiologically relevant therapeutic vulnerability that would be otherwise missed by conventional culture on plastic. This work substantiates HDAC inhibitors as possible therapeutic candidates for the treatment of patients with LAM and requires further study.
Early life predictors of body composition trajectories from adolescence to mid‐adulthood
Authors: Poveda Natalia E. , Adair Linda S. , Martorell Reynaldo. , Patel Shivani A. , Ramirez‐Zea Manuel , Stein Aryeh D. 
Published: July 2023

AbstractObjectivesGuatemala has experienced rapid increases in adult obesity. We characterized body composition trajectories from adolescence to mid‐adulthood and determined the predictive role of parental characteristics, early life factors, and a nutrition intervention.MethodsOne thousand three hundred and sixty‐four individuals who participated as children in a nutrition trial (1969–1977) were followed prospectively. Body composition characterized as body mass index (BMI), fat mass index (FMI), and fat‐free mass indices (FFMI), was available at four ages between 10 and 55 years. We applied latent class growth analysis to derive sex‐specific body composition trajectories. We estimated associations between parental (age, height, schooling) and self‐characteristics (birth order, socioeconomic status, schooling, and exposure to a nutrition supplement) with body composition trajectories.ResultsIn women, we identified two latent classes of FMI (low: 79.6%; high: 20.4%) and BMI (low: 73.0%; high: 27.0%), and three of FFMI (low: 20.2%; middle: 55.9%; high: 23.9%). In men, we identified two latent classes of FMI (low: 79.6%; high: 20.4%) and FFMI (low: 62.4%; high: 37.6%), and three of BMI (low: 43.1%; middle: 46.9%; high: 10.0%). Among women, self's schooling attainment inversely predicted FMI (OR [being in a high latent class]: 0.91, 95% CI: 0.85, 0.97), and maternal schooling positively predicted FFMI (OR: 1.16, 95% CI: 0.97, 1.39). Among men, maternal schooling, paternal age, and self's schooling attainment positively predicted FMI. Maternal schooling positively predicted FFMI, whereas maternal age and paternal schooling were inverse predictors. The nutrition intervention did not predict body composition class membership.ConclusionsParents' age and schooling, and self's schooling attainment are small but significant predictors of adult body composition trajectories.
A pediatric case of multiple trauma with impending cardiac arrest due to hemorrhagic shock successfully treated with resuscitative thoracotomy: A case report
Authors: Hojo Kento , Abe Tomohiro , Saito Katsutoshi , Sasaki Akira , Ochiai Hidenobu 
Published: July 2023

AbstractBackgroundThe effectiveness of resuscitative thoracotomy (RT) in pediatric patients with multiple trauma is limited. We present a pediatric case of multiple trauma successfully treated with RT.Case PresentationA 9‐year‐old boy was injured after falling down stairs. On arrival, his blood pressure was unmeasurable, and the carotid artery pulse was barely palpable. Sonographic assessment indicated intra‐abdominal hemorrhage. RT and aortic cross‐clamping were performed, and he received a blood transfusion, after which his circulatory status recovered. Laparotomy indicated an inferior mesenteric vein injury that was sutured. Ten hours after arrival, an acute epidural hematoma was observed and treated with an emergency craniotomy. The patient's condition remained stable and he was discharged on the 101st day.ConclusionRT may save the life of patients with multiple trauma, even pediatric patients, if performed in a timely manner, based on the diagnosis of hemorrhagic shock, along with rapid transfusion and hemostatic intervention.
What Can a GNOME Do? Search Targets for the Global Network of Optical Magnetometers for Exotic Physics Searches
Authors: Afach Samer , Aybas Tumturk Deniz , Bekker Hendrik , Buchler Ben C. , Budker Dmitry , Cervantes Kaleb , Derevianko Andrei , Eby Joshua , Figueroa Nataniel L. , Folman Ron , Gavilán‐Martín Daniel , Givon Menachem , Grujić Zoran D. , Guo Hong , Hamilton Paul , Hedges Morgan P. , Jackson Kimball Derek F. , Khamis Sami , Kim Dongok , Klinger Emmanuel , Kryemadhi Abaz , Liu Xiyu , Łukasiewicz Grzegorz , Masia‐Roig Hector , Padniuk Mikhail , Palm Christopher A. , Park Sun Yool , Pearson Heather R. , Peng Xiang , Pospelov Maxim , Pustelny Szymon , Rosenzweig Yossi , Ruimi Ophir M. , Scholtes Theo , Segura Perrin C. , Semertzidis Yannis K. , Shin Yun Chang , Smiga Joseph A. , Stadnik Yevgeny V. , Stalnaker Jason E. , Sulai Ibrahim A. , Tandon Dhruv , Vu Kenneth , Weis Antoine , Wickenbrock Arne , Wilson Tatum Z. , Wu Teng , Xiao Wei , Yang Yucheng , Yu Dongrui , Yu Felix , Zhang Jianwei , Zhao Yixin 
Published: July 2023

AbstractNumerous observations suggest that there exist undiscovered beyond‐the‐standard‐model particles and fields. Because of their unknown nature, these exotic particles and fields could interact with standard model particles in many different ways and assume a variety of possible configurations. Here, an overview of the global network of optical magnetometers for exotic physics searches (GNOME), the ongoing experimental program designed to test a wide range of exotic physics scenarios, is presented. The GNOME experiment utilizes a worldwide network of shielded atomic magnetometers (and, more recently, comagnetometers) to search for spatially and temporally correlated signals due to torques on atomic spins from exotic fields of astrophysical origin. The temporal characteristics of a variety of possible signals currently under investigation such as those from topological defect dark matter (axion‐like particle domain walls), axion‐like particle stars, solitons of complex‐valued scalar fields (Q‐balls), stochastic fluctuations of bosonic dark matter fields, a solar axion‐like particle halo, and bursts of ultralight bosonic fields produced by cataclysmic astrophysical events such as binary black hole mergers are surveyed.
p‐Block Bismuth Nanoclusters Sites Activated by Atomically Dispersed Bismuth for Tandem Boosting Electrocatalytic Hydrogen Peroxide Production
Authors: Zhu Pan , Feng Wuyi , Zhao Di , Song Pengyu , Li Mengwei , Tan Xin , Liu Ting , Liu Shoujie , Zhu Wei , Zhuang Zhongbin , Zhang Jiatao , Chen Chen 
Published: July 2023

AbstractConstructing electrocatalysts with p‐block elements is generally considered rather challenging owing to their closed d shells. Here for the first time, we present a p‐block‐element bismuth‐based (Bi‐based) catalyst with the co‐existence of single‐atomic Bi sites coordinated with oxygen (O) and sulfur (S) atoms and Bi nanoclusters (Biclu) (collectively denoted as BiOSSA/Biclu) for the highly selective oxygen reduction reaction (ORR) into hydrogen peroxide (H2O2). As a result, BiOSSA/Biclu gives a high H2O2 selectivity of 95 % in rotating ring‐disk electrode, and a large current density of 36 mA cm−2 at 0.15 V vs. RHE, a considerable H2O2 yield of 11.5 mg cm−2 h−1 with high H2O2 Faraday efficiency of ~90 % at 0.3 V vs. RHE and a long‐term durability of ~22 h in H‐cell test. Interestingly, the experimental data on site poisoning and theoretical calculations both revealed that, for BiOSSA/Biclu, the catalytic active sites are on the Bi clusters, which are further activated by the atomically dispersed Bi coordinated with O and S atoms. This work demonstrates a new synergistic tandem strategy for advanced p‐block‐element Bi catalysts featuring atomic‐level catalytic sites, and the great potential of rational material design for constructing highly active electrocatalysts based on p‐block metals.
General Design Concepts for CAPodes as Ionologic Devices
Authors: Zhou Hanfeng , Li Panlong , Zhang En , Kunigkeit Jonas , Zhou Xiongjun , Haase Katherina , Rita Ortega Vega Maria , Wang Shuwen , Xu Xiaosa , Grothe Julia , Mannsfeld Stefan C. B. , Brunner Eike , Kaneko Katsumi , Kaskel Stefan 
Published: July 2023

AbstractCapacitive analogues of semiconductor diodes (CAPodes) present a new avenue for energy‐efficient and nature‐inspired next‐generation computing devices. Here, we disclose the generalized concept for bias‐direction‐adjustable n‐ and p‐CAPodes based on selective ion sieving. Controllable‐unidirectional ion flux is realized by blocking electrolyte ions from entering sub‐nanometer pores. The resulting CAPodes exhibit charge‐storage characteristics with a high rectification ratio (96.29 %). The enhancement of capacitance is attributed to the high surface area and porosity of an omnisorbing carbon as counter electrode. Furthermore, we demonstrate the use of an integrated device in a logic gate circuit architecture to implement logic operations (‘OR’, ‘AND’). This work demonstrates CAPodes as a generalized concept to achieve p‐n and n‐p analogue junctions based on selective ion electrosorption, provides a comprehensive understanding and highlights applications of ion‐based diodes in ionologic architectures.
Cleavage of Carbon Dioxide C=O Bond Promoted by Nickel‐Boron Cooperativity in a PBP‐Ni Complex
Authors: Álvarez‐Rodríguez Lucía , Ríos Pablo , Laglera‐Gándara Carlos J. , Jurado Andrea , Fernández‐de‐Córdova Francisco José , Gunnoe T. Brent , Rodríguez Amor 
Published: July 2023

AbstractThe synthesis and characterization of (tBuPBP)Ni(OAc) (5) by insertion of carbon dioxide into the Ni−C bond of (tBuPBP)NiMe (1) is presented. An unexpected CO2 cleavage process involving the formation of new B−O and Ni−CO bonds leads to the generation of a butterfly‐structured tetra‐nickel cluster (tBuPBOP)2Ni4(μ‐CO)2 (6). Mechanistic investigation of this reaction indicates a reductive scission of CO2 by O‐atom transfer to the boron atom via a cooperative nickel‐boron mechanism. The CO2 activation reaction produces a three‐coordinate (tBuP2BO)Ni‐acyl intermediate (A) that leads to a (tBuP2BO)−NiI complex (B) via a likely radical pathway. The NiI species is trapped by treatment with the radical trap (2,2,6,6‐tetramethylpiperidin‐1‐yl)oxyl (TEMPO) to give (tBuP2BO)NiII(η2‐TEMPO) (7). Additionally, 13C and 1H NMR spectroscopy analysis using 13C‐enriched CO2 provides information about the species involved in the CO2 activation process.
Geometrically Constrained Organoboron Species as Lewis Superacids and Organic Superbases
Authors: Lv Weiwei , Dai Yuyang , Guo Rui , Su Yuanting , Ruiz David A. , Liu Liu Leo , Tung Chen‐Ho , Kong Lingbing 
Published: July 2023

AbstractThis report unveils an advancement in the formation of a Lewis superacid (LSA) and an organic superbase by the geometrical deformation of an organoboron species towards a T‐shaped geometry. The boron dication [2]2+ supported by an amido diphosphine pincer ligand features both a large fluoride ion affinity (FIA>SbF5) and hydride ion affinity (HIA>B(C6F5)3), which qualifies it as both a hard and soft LSA. The unusual Lewis acidic properties of [2]2+ are further showcased by its ability to abstract hydride and fluoride from Et3SiH and AgSbF6 respectively, and effectively catalyze the hydrodefluorination, defluorination/arylation, as well as reduction of carbonyl compounds. One and two‐electron reduction of [2]2+ affords stable boron radical cation [2]⋅+ and borylene 2, respectively. The former species has an extremely high spin density of 0.798e at the boron atom, whereas the latter compound has been demonstrated to be a strong organic base (calcd. pKBH+ (MeCN)=47.4) by both theoretical and experimental assessment. Overall, these results demonstrate the strong ability of geometric constraining to empower the central boron atom.
Photosensitized [4+2]‐ and [2+2]‐Cycloaddition Reactions of N‐Sulfonylimines
Authors: Wang Wang , Brown M. Kevin 
Published: July 2023

AbstractThe synthesis of polycyclic compounds is of high interest due to the prevalence of these motifs in drugs and natural products. Herein, we report on the stereoselective construction of 3D bicyclic scaffolds and azetidine derivatives by modulation of N‐sulfonylimines to achieve either [4+2]‐ or [2+2]‐cycloaddition reactions. The utility of the method was established by further modulation of the product. Mechanistic studies are also included, which support reaction via Dexter energy transfer.
Synthesis of Cobalt‐Tin and ‐Lead Tetrylidynes—Reactivity Study of the Triple Bond
Authors: Auer Maximilian , Zwettler Kathrin , Eichele Klaus , Schubert Hartmut , Sindlinger Christian P. , Wesemann Lars 
Published: July 2023

AbstractTetrylidynes [TbbSn≡Co(PMe3)3] (1 a) and [TbbPb≡Co(PMe3)3] (2) (Tbb=2,6‐[CH(SiMe3)2]2‐4‐(t‐Bu)C6H2) are accessed for the first time via a substitution reaction between [Na(OEt2)][Co(PMe3)4] and [Li(thf)2][TbbEBr2] (E=Sn, Pb). Following an alternative procedure the stannylidyne [Ar*Sn≡Co(PMe3)3] (1 b) was synthesized by hydrogen atom abstraction using AIBN from the paramagnetic hydride complex [Ar*SnH=Co(PMe3)3] (4) (AIBN=azobis(isobutyronitrile)). The stannylidyne 1 a adds two equivalents of water to yield the dihydroxide [TbbSn(OH)2CoH2(PMe3)3] (5). In reaction of the stannylidyne 1 a with CO2 a product of a redox reaction [TbbSn(CO3)Co(CO)(PMe3)3] (6) was isolated. Protonation of the tetrylidynes occurs at the cobalt atom to give the metalla‐stanna vinyl cation [TbbSn=CoH(PMe3)3][BArF4] (7 a) [ArF=C6H3‐3,5‐(CF3)2]. The analogous germanium and tin cations [Ar*E=CoH(PMe3)3][BArF4] (E=Ge 9, Sn 7 b) (Ar*=C6H3(2,6‐Trip)2, Trip=2,4,6‐C6H2iPr3) were also obtained by oxidation of the paramagnetic complexes [Ar*EH=Co(PMe3)3] (E=Ge 3, Sn 4), which were synthesized by substitution of a PMe3 ligand of [Co(PMe3)4] by a hydridoylene (Ar*EH) unit.
Promoting Photocatalytic H2 Evolution through Retarded Charge Trapping and Recombination by Continuously Distributed Defects in Methylammonium Lead Iodide Perovskite
Authors: Yao Qing , Li Hui , Xue Jiawei , Jiang Shenlong , Zhang Qun , Bao Jun 
Published: July 2023

AbstractInspired by its great success in the photovoltaic field, methylammonium lead iodide perovskite (MAPbI3) has recently been actively explored as photocatalysts in H2 evolution reactions. However, the practical application of MAPbI3 photocatalysts remains hampered by the intrinsically fast trapping and recombination of photogenerated charges. Herein, we propose a novel strategy of regulating the distribution of defective areas to promote charge‐transfer dynamics of MAPbI3 photocatalysts. By deliberately designing and synthesizing the MAPbI3 photocatalysts featuring a unique continuation of defective areas, we demonstrate that such a feature enables retardation of charge trapping and recombination via lengthening the charge‐transfer distance. As an outcome, such MAPbI3 photocatalysts turn out to achieve an impressive photocatalytic H2 evolution rate as high as 0.64 mmol ⋅ g−1 ⋅ h−1, one order of magnitude higher than that of the conventional MAPbI3 photocatalysts. This work establishes a new paradigm for controlling charge‐transfer dynamics in photocatalysis.
Measuring and maintaining organ perfusion in a patient with Takayasu's arteritis undergoing cardiac surgery*
Authors: Dan K. , Takahashi K. , Lefor A. K. 
Published: July 2023

SummaryTakayasu's arteritis is a rare vasculitis affecting the aorta and its branches. Disease progression can result in arterial stenosis and subsequent organ dysfunction. Estimating organ perfusion by measuring the peripheral blood pressure can be challenging because it may be altered by arterial stenosis. We report the case of a 61‐year‐old woman with Takayasu's arteritis with aortic and mitral regurgitation who presented for aortic valve replacement and mitral valvuloplasty. Peripheral arterial pressure was considered a less reliable surrogate for organ perfusion because the patient had diminished blood flow in both the lower and upper extremities. In addition to the bilateral radial arterial pressure, the blood pressure in the ascending aorta was monitored to estimate the patient's organ perfusion pressure during cardiopulmonary bypass. The initial target blood pressure was determined based on the pre‐operative baseline and modified by measurement of the aortic pressure. Cerebral oximetry using near‐infrared spectroscopy and mixed venous saturation was monitored to estimate oxygen supply‐demand balance, which helped evaluate cerebral perfusion and determine the transfusion threshold. The entire procedure was uneventful, and no organ dysfunction was observed postoperatively.
A novel psychotherapy for low‐needs youth on the autism spectrum with emotional regulation challenges
Authors: McGuinty Everett , Carlson Alain , Nelson John , Scott Cailin 
Published: July 2023

AbstractThe externalising of problems and implementation of interactive metaphors may improve emotional regulation of those clients presenting with autism spectrum disorder. This paper describes a new eight‐session treatment protocol in terms of using preferred interest metaphors with the strengths and strategies of client and family across the home, school, and community settings of client life. This exploratory treatment intervention uses externalising metaphors therapy as a brief treatment modality, addressing emotional regulation concerns of youth on the autism spectrum. The treatment model concretises affective states and creatively leverages visual strengths to improve this common presenting concern for this population. A case study on family therapy is presented with the protocol overview and illustrations. Further research is needed to address the testable hypotheses and identify the mediators of change resulting from this current model. This research would help to establish best practices in a clinical population for which there is no broadly accepted treatment paradigm. Mr. McGuinty has indicated that there are no conflicts of interest in this manuscript.
New palladium (II) and platinum (II) complexes with coumarin based O,N,N pincer: Synthesis, structure elucidation, BSA protein binding studies, and anticancer activity
Authors: Bera Biswajit , Mondal Sanchaita , Mandal Subrata , Das Saha Krishna , Mondal Tapan K. 
Published: July 2023

New Pd (II) and Pt (II) complexes (C1/C2) with a O,N,N donor pincer ligand, 4‐hydroxy‐3‐((E)‐1‐(((Z)‐phenyl (pyridin‐2‐yl)methylene)hydrazono)ethyl)‐2H‐chromen‐2‐one (HL) were synthesized and methodically characterized by several spectroscopic and XRD techniques. Absorption and fluorescence techniques were used to assess the mechanism of interaction of the complexes with bovine serum albumin protein. MTT assay was executed to investigate the antiproliferative activity of the complexes with several cancer cell lines (MCF‐7, HCT116, A549, and HepG2) along with a normal cell line (PBMC). Both C1 and C2 showed better antiproliferative activity with HepG2 cell line (IC50 value of 15.3 and 5.1 μM, respectively). A cytotoxicity study was performed, and complex C2 exhibited a better antiproliferative activity as compared to C1. The morphological changes were also examined by staining methods, and fragmented DNA unveiled that the cell death took place through apoptosis.