bluuebunny/crossref_metadata_2025_split huggingface dataset:
The amino acid stress sensing eIF2α kinase GCN2 is a survival biomarker for malignant mesothelioma
Authors: Gold Lyssa T. , Bray Susan E. , Kernohan Neil M. , Henderson Nina , Nowicki Maisie , Masson Glenn R. 
Published: March 2023

AbstractBackgroundMalignant mesothelioma is a tumour that is strongly associated with a history of asbestos exposure and which derives from mesothelial cells that line the serous cavities of the body. The tumour most commonly arises in the pleural cavity, but can also arise in the pericardium, peritoneum and tunica vaginalis. At present the lesion has a very poor prognosis and is an incurable form of cancer with median survival times of up to 19 months being quoted for some histological subtypes. A large proportion of mesotheliomas have been shown to be arginine auxotrophic, leading to new research for therapeutics which might exploit this potential vulnerability.MethodWe measured the levels of General Control Non-derepressible 2 (GCN2) protein in malignant mesothelioma tumour samples and determined whether these levels correlate with clinical outcomes.ResultsWe observed that the expression levels of GCN2 correlated with patient survival and was an independent prognostic variable in pairwise comparison comparisons with all available clinical data.ConclusionThese findings suggest that GCN2 levels provides prognostic information and may allow for stratification of care pathways. It may suggest that targeting GCN2 is a viable strategy for mesothelioma therapy development.
Mapping pQTLs of circulating inflammatory proteins identifies drivers of immune-related disease risk and novel therapeutic targets
Authors:   The SCALLOP consortium, Zhao Jing Hua , Stacey David , Eriksson Niclas , Macdonald-Dunlop Erin , Hedman Åsa K , Kalnapenkis Anette , Enroth Stefan , Cozzetto Domenico , Digby-Bell Jonathan , Marten Jonathan , Folkersen Lasse , Herder Christian , Jonsson Lina , Bergen Sarah E , Geiger Christian , Needham Elise J , Surendran Praveen ,   Estonian Biobank Research Team, Paul Dirk S , Polasek Ozren , Thorand Barbara , Grallert Harald , Roden Michael , Võsa Urmo , Esko Tonu , Hayward Caroline , Johansson Åsa , Gyllensten Ulf , Powell Nicholas , Hansson Oskar , Mattsson-Carlgren Niklas , Joshi Peter K , Danesh John , Padyukov Leonid , Klareskog Lars , Landén Mikael , Wilson James F , Siegbahn Agneta , Wallentin Lars , Mälarstig Anders , Butterworth Adam S , Peters James E 
Published: March 2023

ABSTRACTCirculating proteins play key roles in inflammation and a broad range of diseases. To identify genetic influences on inflammation-related proteins, we conducted a genome-wide protein quantitative trait locus (pQTL) study of 91 plasma proteins measured using the Olink Target platform in 15,150 participants. We identified 180 pQTLs, of which 50 were novel. Integration of pQTL data with eQTL and disease GWAS provided insights into pathogenesis, implicating lymphotoxin-alpha (LTA) in multiple sclerosis. Using Mendelian randomisation (MR), we identified both shared and distinct effects of specific proteins across immune-mediated diseases, including directionally discordant causal roles for CD40 in rheumatoid arthritis, multiple sclerosis and inflammatory bowel disease. Our results highlight novel potential therapeutic avenues, including CXCL5 in ulcerative colitis (UC), a finding supported by elevated gutCXCL5expression in UC patients. Our data provide a powerful resource to facilitate future drug target prioritization.
Sequential viral introductions and spread of BA.1 drove the Omicron wave across Pakistani provinces
Authors: Bukhari Ali Raza , Ashraf Javaria , Kanji Akbar , Rahman Yusra Abdul , Trovão Nídia S. , Thielen Peter M. , Yameen Maliha , Kanwar Samiah , Khan Waqasuddin , Kabir Furqan , Nisar M. Imran , Merritt Brian , Hasan Rumina , Spiro David , Rasmussen Zeba , Aamir Uzma Bashir , Hasan Zahra 
Published: March 2023

AbstractBackgroundCOVID-19 waves caused by specific SARS-CoV-2 variants have occurred globally at different times. We focused on Omicron variants to understand the genomic diversity and phylogenetic relatedness of SARS-CoV-2 strains in various regions of Pakistan.MethodsWe studied 276,525 COVID-19 cases and 1,041 genomes sequenced from December 2021 to August 2022. Sequences were analyzed and visualized using phylogenetic trees.ResultsThe highest case numbers and deaths were recorded in Sindh and Punjab, the most populous provinces in Pakistan. Omicron variants comprised 95% of all genomes, with BA.2 (34.2%) and BA.5 (44.6%) predominating. The first Omicron wave was associated with the sequential identification of BA.1 in Sindh, then Islamabad Capital Territory, Punjab, Khyber Pakhtunkhwa (KP), Azad Jammu Kashmir (AJK), Gilgit-Baltistan (GB) and Balochistan. Phylogenetic analysis revealed Sindh to be the source of BA.1 and BA.2 introductions into Punjab and Balochistan during early 2022. BA.4 was first introduced in AJK and BA.5 in Punjab. Most recent common ancestor (MRCA) analysis revealed relatedness between the earliest BA.1 genome from Sindh with Balochistan, AJK, Punjab and ICT, and that of first BA.1 from Punjab with strains from KPK and GB.ConclusionsPhylogenetic analysis provides insights into the introduction and transmission dynamics of the Omicron variant in Pakistan, identifying Sindh as a hotspot for viral dissemination. Such data linked with public health efforts can help limit surges of new infections.
21st century leadership research in hospitality management: a state-of-the-art systematic literature review
Authors: Guchait Priyanko , Peyton Taylor , Madera Juan M. , Gip Huy , Molina-Collado Arturo 
Published: March 2023

PurposeThis study aims to examine the scientific publications related to leadership research in hospitality from 2000 to 2021 by conducting a systematic review (qualitative) and to discuss implications for future research.Design/methodology/approachFor the qualitative approach, the authors conduct an in-depth critique of major leadership theories using 167 articles indexed in the Web of Science Core Collection.FindingsThe findings show that transformational leadership, leader–member exchange and servant leadership are the most prominent leadership topics studied from 2000 to 2021, followed by abusive supervision, empowering leadership, ethical leadership and authentic leadership. A framework is presented highlighting the mediators, moderators, outcomes, sample and research designs used in each of these lines of leadership research. Moreover, 16 areas for further research are identified and discussed.Practical implicationsThis review uncovers scholars’ general lack of regard for how the study of leadership might benefit from examining hospitality as a special and challenging context for leadership and business performance.Originality/valueThis study reviews and critically analyzes leadership research in hospitality using qualitative methods. Therefore, the authors believe this review is of great value to academics and practitioners because it synthesizes and analyzes the field and identifies important research opportunities.
“Control yourself or someone else will control you. Effect of job demands on employee burnout: a perspective from self-regulation theory”
Authors: Zeshan Muhammad , Khatti Shahzil Talha , Afridi Fiza , de La Villarmois Olivier 
Published: March 2023

Purpose
This paper aims to show the role of employees’ self-regulation in defining the effect of job demands on employees’ burnout. Moreover, the paper also highlights the importance of a high-performance work system (HPWS) on the relation between job demands and employee self-regulation.

Design/methodology/approach
Data has been collected from public sector hospital nurses through a survey strategy following a time-lagged approach. This data has been analysed to validate the measure and to test the hypotheses through structural equation modelling.

Findings
Results of this study indicate that job demands affect employees’ burnout through adaptive regulation (recovery) and maladaptive regulation (self-undermining). Adaptive regulation minimizes while maladaptive regulation supports this effect. Moreover, results also highlight the role of HPWS in mitigating the negative impact of job demands on adaptive regulation.

Practical implications
This study serves as a guide for managers to minimize the burnout of their subordinates in the face of increasing job demands. This study also emphasizes the use of HPWS in organizations so that the burnout of the employees may be decreased by increasing adaptive self-regulation or recovery.

Originality/value
This study enriches the literature on the job demand resource theory by showing how employee job demands, employee self-regulation (psychological processes) and HPWS (organizational processes) collaborate to determine the extent of job burnout of employees.
Modelling and analysing the enablers of digital resilience for small and medium enterprises
Authors: Kumar Vikas , Sindhwani Rahul , Behl Abhishek , Kaur Amanpreet , Pereira Vijay 
Published: March 2023

PurposeSmall and medium enterprises (SMEs) significantly contribute to economic growth, development, exports and employment of the nations. To maintain competitiveness in today's market, SMEs must explore and identify enablers to enhance their digital transformation process. This paper aims to shed light on some essential enablers SMEs can use to implement digital resilience successfully.Design/methodology/approachThe quantitative assessment and validation of the enablers have been done using powerful and novel techniques, namely, the Delphi method, “fuzzy interpretive structural modelling” (F-ISM) method and “cross-impact matrix multiplication applied to classification (MICMAC)” analysis. The F-ISM model is developed using the information drawn from digital transformation experts and practitioners involved in the digital transformation process for SMEs. Furthermore, the F-ISM model provides four paths to complete the pathway to digital resilience.FindingsThe F-ISM and MICMAC analysis revealed four ways to enhance the digital transformation process in SMEs. These enterprises can utilise these path assessments to become digitally resilient in the present dynamic scenario. To enhance digital resilience among SMEs, the study identified ten enablers. Among these, “management competencies” was the most crucial, followed by “knowledge management” and “monitoring and controlling”.Research limitations/implicationsThe present study is limited in that the data used to develop the models were collected from a small group of industry experts whose opinions may not exhibit the comprehensive views of the population.Practical implicationsThe findings can help SMEs enhance the digital transformation process by taking up different pathways to integrate the various enablers of digital resilience depending on resource availability.Originality/valueThe results indicate the most critical and influential enablers for enhancing digital resilience among SMEs. This research can be valuable to academicians, industry practitioners and researchers for guiding their future work.
Exploring Shariah audit practices in zakat and waqf institutions in Malaysia
Authors: Kamaruddin Muhammad Iqmal Hisham , Shafii Zurina , Hanefah Mustafa Mohammed , Salleh Supiah , Zakaria Nurazalia 
Published: March 2023

Purpose
This study aims to explore the current Shariah audit practices in zakat and waqf institutions in Malaysia.

Design/methodology/approach
A focus group discussion (FGD) with 38 zakat and waqf officers from 17 different zakat and waqf institutions in Malaysia was conducted. For reporting purposes, this study used a single-case study approach. The FGD was conducted and completed at the end of June 2021 via an online approach through Microsoft Teams.

Findings
The finding highlights the existing Shariah governance practices especially in terms of Shariah supervision roles, Shariah audit implementation in terms of Shariah audit scopes and common findings, Shariah audit competency, Shariah audit effectiveness especially the need for external Shariah audit function and Shariah audit issues and challenges faced in the implementation of Shariah audit practices.

Practical implications
The study findings and recommendations are useful for zakat and waqf institutions as well as the State Islamic Religious Councils to enhance Shariah audit practices in Malaysia.

Originality/value
This study is among the pioneer studies that explore Shariah audit practices in zakat and waqf institutions in Malaysia.
Government administrative capacity, e-government performance and citizen’s e-government adoption: evidence from a transition country
Authors: Tran Pham Toan Khanh 
Published: March 2023

Purpose
The purpose of this study is to investigate the impact of government administrative capacity and e-government performance on the citizens’ intention to use e-government services by integrating into the technology acceptance model (TAM). In addition, the study investigates the mediating effect of perceived usefulness in these nexus.

Design/methodology/approach
A quantitative and cross-sectional approach is used to gather the data from 443 respondents in Vietnam. The squares structural equation modeling is used to access the impact of government administrative capacity and e-government performance on the citizens’ intention to use e-government, the mediating effect of perceived usefulness.

Findings
The results show that e-government performance, government administrative capacity and perceived usefulness are critical determinants of citizens’ intention. Furthermore, government administrative capacity positively impacts e-government performance. More importantly, perceived usefulness plays a mediating role in these relationships. The results also show that both age and qualification moderate the relationship between perceived usefulness and intention.

Practical implications
The findings of this study provide valuable evidence and implications. Public officials must enhance the administrative capacity as the determination for the application of e-government. They must demonstrate their commitment to implementing e-government initiatives. Moreover, the government should continually carry out policies to improve e-government performance.

Originality/value
This study uses the TAM by incorporating government administrative capacity and e-government performance. Evidence about the mechanism linking government administrative capacity and e-government performance to citizens' intention to use e-government is scant. With this stated, this study fills these gaps by pioneering exploring the mediating role of perceived usefulness in these relationships.
Immersive simulation and experimental design in risk and crisis management: Implications for learning
Authors: Petridou Evangelia , Sparf Jörgen , Hemmingsson Olov , Pihl Kari 
Published: March 2023

AbstractExperiments have long been recognized as effective tools in teaching natural sciences and, to a lesser degree, in social sciences. However, understanding the role of immersive simulation experiments in undergraduate degree programmes demands more scholarly attention, given the pace of technological advances and research literacy in immersive simulation. The purpose of this article is to illustrate the potential of integrating immersive simulation laboratory experiments in social science education and specifically in a risk and crisis management undergraduate degree programme. Based on the work of Claire Dunlop, we demonstrate how an experiment with a high degree of experimental realism was a fruitful vehicle for initiating conversations about sensitive subjects in a safe environment and made teaching more inclusive, while high mundane realism made teaching risk and crisis management fun, and, we argue, fostered practical aspects of risk and crisis management.
How Do Firms Respond to Political Uncertainty? Evidence from U.S. Gubernatorial Elections
Authors: BIRD ANDREW , KAROLYI STEPHEN A. , RUCHTI THOMAS G. 
Published: March 2023

ABSTRACTWe examine the joint response to political uncertainty along two margins: changes in real activity and voluntary disclosure. We focus on within‐firm variation in exposure to ex ante competitive U.S. gubernatorial elections using data on preelection poll margins and firms’ state exposures. Despite real activity falling in the years leading up to a close election, we find that voluntary disclosure increases both in frequency and content, including mentions of risk in filings that reference states holding elections. Our tests use a decomposition of 8‐K filings into real activity and voluntary disclosure to address the endogenous complementarity between these two responses. These results hold when using alternative ex ante measures of political uncertainty based on term‐limited incumbents, historically competitive offices, or state legislature gridlock. Both effects of political uncertainty are stronger for firms in highly regulated industries and weaker for those least exposed to the local market, linking the real activity and disclosure responses to uncertainty.
Sodium chloride or plasmalyte‐148 for patients presenting to emergency departments with diabetic ketoacidosis: A nested cohort study within a multicentre, cluster, crossover, randomised, controlled trial
Authors: Attokaran Antony George , Ramanan Mahesh , Hunt Lisa , Chandra Kavita , Sandha Rajbir , Watts Stacey , Venkatesh Balasubramanian 
Published: March 2023

AbstractObjectiveTo test the hypothesis that fluid resuscitation in the ED with plasmalyte‐148 (PL) compared with 0.9% sodium chloride (SC) would result in a lower proportion of patients with diabetic ketoacidosis (DKA) requiring intensive care unit (ICU) admission.MethodsWe performed a prespecified nested cohort study at two hospitals within a cluster, crossover, open label, randomised, controlled trial comparing the effects of PL versus SC as fluid therapy for patients who presented to the ED with DKA. All patients presenting within a fixed recruitment period were included. The primary outcome was the proportion of patients admitted to ICU.ResultsEighty‐four patients were enrolled (SC n = 38, PL n = 46). The SC group had a lower median pH on admission (SC: 7.09 [interquartile range (IQR) 7.01–7.21], PL: 7.17 [IQR 6.99–7.26]). The median volume of intravenous fluids administered in ED was 2150 mL (IQR 2000–3200 mL; SC) and 2200 mL (IQR 2000–3450; PL); respectively. A higher proportion of patients in the SC group, 19 (50%), was admitted to ICU compared with PL group, 18 (39.1%); however, after adjustment for pH at presentation and diabetes type in a multivariable logistic regression model, the PL group did not have a significantly different rate of ICU admission compared with the SC group (odds ratio for ICU admission 0.73, 95% confidence interval 0.13–3.97, P = 0.71).ConclusionPatients with DKA treated with PL compared with SC in the EDs had similar rates of requiring ICU admission.
Trends and patterns of care of sentinel node biopsy in cutaneous melanoma: a population‐based study in Queensland
Authors: Wong Jessica , Moore Julie , Soyer H. Peter , Mar Victoria , Smithers B. Mark 
Published: March 2023

AbstractBackgroundSentinel node biopsy (SNB) has evolved from offering staging and prognostication to a procedure that guides therapeutic management. The aim was to evaluate the rate of SNB for patients with high‐risk melanoma and assess factors that may have impacted on the procedure being performed.MethodsData of patients with primary invasive cutaneous melanoma from 01 January 2009 to 31 December 2019 were obtained from the Queensland Oncology Repository. High‐risk melanoma was defined as ≥0.8 mm thick or < 0.8 mm with ulceration present (AJCC eighth edition pT1b–pT4).Results14 006 (33.8%) of 41 412 patients diagnosed with cutaneous invasive melanoma were in the high‐risk group. 2923(20.9%) patients had SNB, with the rate increasing from 14.2% (2009) to 36.8% (2019) (P = 0.002), and an increasing proportion being performed in public hospitals over the 11 year period (P = 0.02). Older age (OR0.96 (0.959–0.964) (P < 0.001)), female (OR0.91 (0.830–0.998) (P = 0.03)), head and neck primary (OR0.38 (0.33–0.45) (P < 0.001)), and pT1b (OR0.22 (0.19–0.25) (P < 0.001)) were factors associated with SNB not being performed. Travel out of the Hospital and Health Services of residence for SNB occurred in 26.2%. Although the travel rate decreased from 24.7% (2009) to 23.0% (2019) (P = 0.04), the absolute number increased due to the increase in SNB rate. Those most likely to travel were younger, from remote areas, or from affluent backgrounds.ConclusionIn this first Australian population‐based study, there was an increased adherence to SNB guideline, although overall SLNB rates remain low, with nearly 2/3 of eligible cases not having the procedure in 2019. Although travel rates decreased marginally, the overall number increased. This study highlights the crucial need to further improve access to SNB for melanoma surgery for the Queensland population.
Decoupled responses of biodiversity facets driven from anuran vulnerability to climate and land‐use changes
Authors: Ceron Karoline , Sales Lilian P. , Santana Diego J. , Pires Mathias M. 
Published: March 2023

AbstractBiodiversity loss not only implies the loss of species but also entails losses in other dimensions of biodiversity, such as functional, phylogenetic and interaction diversity. Yet, each of those facets of biodiversity may respond differently to extinctions. Here, we examine how extinction, driven by climate and land‐use changes may affect those different facets of diversity by combining empirical data on anuran–prey interaction networks, species distribution modelling and extinction simulations in assemblages representing four Neotropical ecoregions. We found a mismatch in the response of functional, phylogenetic and interaction diversity to extinction. In spite of high network robustness to extinction, the effects on interaction diversity were stronger than those on phylogenetic and functional diversity, declining linearly with species loss. Although it is often assumed that interaction patterns are reflected by functional diversity, assessing species interactions may be necessary to understand how species loss translates into the loss of ecosystem functions.
Personalizing Large‐Scale Assessment in Practice
Authors: Buzick Heather M. , Casabianca Jodi M. , Gholson Melissa L. 
Published: March 2023

AbstractThe article describes practical suggestions for measurement researchers and psychometricians to respond to calls for social responsibility in assessment. The underlying assumption is that personalizing large‐scale assessment improves the chances that assessment and the use of test scores will contribute to equity in education. This article describes a spectrum of standardization and personalization in large‐scale assessment. Informed by a review of existing theories, models, and frameworks in the context of current and developing technologies and with a social justice lens, we propose steps to take, as part of assessment research and development, to contribute to the science of personalizing large‐scale assessment in technically defensible ways.