bluuebunny/crossref_metadata_2025_split huggingface dataset:
Role of saffron and chamomile in Parkinson diseases
Authors: Ali Fizzah , Ahmed Junaid , Saara Ahmad  
Published: March 2023

Madam,
Parkinson's disease (PD) is a distinctive neurodegenerative disorder with a multifactorial range of etiology and symptoms. The pathophysiology behind the condition is a complex array of abnormal alpha-synuclein aggregation, mitochondrial dysfunction, oxidative stress, and neuroinflammation that leads to reduced dopaminergic expression, and neuronal cell death (1, 2).
In multitudinous preclinical studies, Saffron and Chamomile are effective in treating PD. Saffron can mitigate the neurodegenerative progression of the disease by curtailing dopaminergic and neuronal loss and inhibiting alpha-synuclein aggregation. It also possesses antioxidant and anti-inflammatory activities (3). In-silico studies also demonstrated the action of active compounds of Saffron, including crocin, crocetin, and safranal, against potential targets of PD (1).
Chamomile and its active compound Apigenin are beneficial in movement disorders in Parkinson's disease (4). It possesses neuroprotective, anti-inflammatory and antioxidant activities. It also has demonstrated activity against potential biomarkers of PD, including: Interleukin-6, Tumor Necrotic factor-alpha, Malonaldehyde, alpha-synuclein, Glial fibrillary acidic protein and also on Tyrosine Hydroxylase and dopamine receptors expression (2).
Prolonged use of pharmacotherapy is not very beneficial in managing PD. Currently, dopamine-related drugs, including Levodopa, are considered first-line therapy. Despite temporarily alleviating the symptoms they cannot alter the degenerative process of PD (1). It warrants a crucial need for novel therapeutic agents working with diverse mechanisms. Pre-clinically, Saffron and chamomile are efficacious in altering potential disease biomarkers. Both herbs have been easily accessible and utilized since ancient times with numerous benefits and better tolerability. Clinical studies specifically for PD are yet to be analyzed; in different neurological disorders, daily oral consumption of 30mg of Saffron and 1gm to 1.5gm of Chamomile is recommended (3,5). Considering the high cost, a blended intake of saffron and Chamomile could be cost-effective and beneficial in treating the disease. Therefore, though clinical trials are needed for further elaboration, Parkinson's disease and related neurological disorders can be managed by synergising both drugs.
Dostarlimab: A light of hope espied amidst an age-long combat against cancer
Authors: Gul Areeba 
Published: March 2023

Madam, a recent study investigated if checkpoint blockade would be effectual in patients with mismatch repair-deficient (MMRd), locally advanced rectal cancer.1 Patients with MMRd stage II or III rectal adenocarcinoma- treated conventionally via surgery, radiation therapy and chemotherapy- received the intravenous medicament of single-agent dostarlimab, an anti-PD-1 monoclonal antibody, every three weeks for six months.1, 3 Extraordinarily, complete clinical remission was observed in 100% of the patients.1, 4 Twelve patients have undertaken the complete treatment, with an additional six month period of post-treatment follow up, and exhibited no sign of tumor on physical exam, MRI scans, endoscopy, PET scans, digital rectal examination, or biopsy.1 Hence, they were not required to partake in chemoradiotherapy or surgery.1, 4
Dostarlimab, a checkpoint inhibitor, has been utilized as a form of immunotherapy which worked in MMRd colorectal cancer cells amongst which the absence of a DNA repairing gene is observed.2, 4 Dr. Andrea Cercek, explains that ordinarily immunotherapy demonstrates a success rate of approximately 10% when used in colorectal cancer in advanced disease, as opposed to that of dostarlimab at 100%.2
Commonly, checkpoint inhibitors trigger reactions in 1 in 5 patients, and while the majority are easily handled, 3% to 5% suffer extreme complications that may cause difficulty in swallowing, masticating and muscle weakness..4 Another game-changer observed by Cercek et al. is the lack of clinical side-effects.1, 4 In rectal cancer, where arduous treatments can have enfeebling sequelae, comprising bowel, bladder and sexual disfunction, in addition to infertility and neural damage, dostarlimab may also be the key to a good quality of life post cancer survival.3,4
Due to the small sample size, however, there is little data on the efficacy of this treatment. Results, though promising, will require a bigger group of patients to add to their credibility. 3,4 Follow up-s spanning a lengthier period would ensure that there are no relapses or sideeffects and that the drug has proved remedial. 1, 3, 4 Furthermore, as suggested by Dr. Cercek, this hypothesis should be tested in other MMRd solid tumours such as stomach, pancreatic and bladder cancer, which have similar potential for successful immunotherapy.2 Dostarlimab’s previous success with endometrial cancer adds promise to this vision.5 The National Health Service in the UK, via the Cancer Drugs Fund, is offering dostarlimab to 100 women every year for endometrial cancer treatment, which costs $11,000 per dose.4, 5
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Factors Contributing to Extreme Polarization of the Society in South Africa
Authors: Madjozi Nelson 
Published: March 2023

Purpose: The study sought to analyze the factors contributing to extreme polarization of the society in South Africa
Methodology: The study adopted a desktop methodology. Desk research refers to secondary data or that which can be collected without fieldwork. Desk research is basically involved in collecting data from existing resources hence it is often considered a low cost technique as compared to field research, as the main cost is involved in executive’s time, telephone charges and directories. Thus, the study relied on already published studies, reports and statistics. This secondary data was easily accessed through the online journals and library.
Findings: The results show that polarization is strongly path dependent and sensitive to stochastic variation. Second, polarization depends strongly on the initial distribution of opinions in the population. In the absence of extremists, polarization may be mitigated. Noisy communication can drive a population toward more extreme opinions and even cause acute polarization. Finally, the apparent reduction in polarization under increased cultural complexity arises via a particular property of the polarization measurement, under which a population containing a wider diversity of extreme views is deemed less polarized.
Unique Contribution to Theory, Practice and Policy: The social comparison theory and Robert Tallisie theory may be used to anchor future studies in the political sector. The study results will also benefit other stakeholders such as the policy makers as well as researchers and scholars from different parts of the world. The top management of politics in the country will also use the study findings to improve the society and ensure high and stable performance in all their activities and programs. The study recommends that the adoption of effective social protection development policies in the society will help to improve efficiency in their major operations and activities. This work has implications for understanding the population dynamics of beliefs opinions and polarization as well as broader implications for the analysis of agent-based models of social phenomena.
Lessons from Our Sweetgrass Baskets: A Wholistic Vision of Academic Success for Indigenous Women in Higher Education
Authors: Brant Jennifer 
Published: March 2023

This qualitative inquiry documents the lessons gleaned from my journey toward the praxis of Indigenous Maternal Pedagogies, an Indigenous women-centred teaching and learning engagement, to offer insights for supporting Indigenous women in higher education. Specifically, this article offers an express vision for Indigenous women’s educational access and success in higher education by sharing a collective research story offered by Indigenous women participants who completed one or more of three courses related to Indigenous women’s literatures and Indigenous maternal theory. Each course was delivered through a decolonial feminist lens, comprised of Indigenous curricular content and engaged students in culturally relevant assessment. This work connects Maternal Pedagogies with Indigenous epistemologies that embrace the “whole student” within educational contexts to establish a teaching and learning environment that can speak to the hearts and minds of students. In the spirit of reconciliation, I position this environment as a safe space where students can be their whole authentic selves and where their realities and lived experiences are positioned as strengths and key assets to establishing an ethical space for cross-cultural and anti-racist dialogue. Collectively, the participant narratives offer four key lessons that are integral to reconciliation education more broadly, and I map these lessons as final recommendations that align with Kirkness and Barnhardt’s timeless work on the “Four Rs” of respect, relevance, reciprocity, and responsibility.
INTERAÇÃO INTERSETORIAL E A PRODUÇÃO DAS COMMODITIES AGRÍCOLAS NA REGIÃO CENTRO-OESTE: UMA ABORDAGEM ESPACIAL / INTERSETORIAL INTERACTION AND THE PRODUCTION OF AGRICULTURAL COMMODITIES IN THE BRAZILIAN CENTRAL-WEST REGION: A SPACE APPROACH
Authors: Farias do Nascimento Erianne , Justo Wellington Ribeiro 
Published: March 2023

Considerando a importância da agropecuária para a região Centro-Oeste, o objetivo deste trabalho é estimar o impacto da produção agropecuária, industrial e do setor de serviços na produção das culturas agrícolas da soja, do milho e do algodão herbáceo na região usando o instrumental da econometria espacial. Os resultados da Análise Exploratória dos Dados Espaciais (AEDE) mostram que há uma concentração do cultivo das três culturas na área central e no nordeste da região que refletem a formação heterogênea da agropecuária no espaço. As estimações para cada cultura revelaram que de forma geral há um efeito transbordamento significativo e cooperação entre os municípios produtores da região e um efeito positivo da agropecuária na produção das três culturas.

Considering the importance of agriculture for the Brazilian Central-West region, the aim of this article is to estimate the impact the sectors of the economy in production off soybean, maize and herbaceous cotton crop production in the region on using the instruments of spatial econometrics. The results of the Exploratory Analysis of Spatial Data (EASD) show that there is a concentration of the cultivation of the three crops in the central area and in the northeast of the region that reflect the heterogeneous formation of agriculture in space. Estimates for each crop showed that in general there is a significant spillover effect and cooperation among municipalities producers in the region. There are positive effects of agricultural in production of tree crops.
A DEPENDÊNCIA DO AGRONEGÓCIO BRASILEIRO EM RELAÇÃO AOS FERTILIZANTES IMPORTADOS / The dependence of Brazilian agribusiness on imported fertilizers
Authors: Arruda de Oliveira Thiago José , Dorner Stefan Hubertus , Munhoz de Almeida Rodrigo Estevam 
Published: March 2023

Em vista dos confrontos armados na Ucrânia e as suas consequências negativas para o agronegócio brasileiro, analisou-se o seu nível de dependência com os fertilizantes importados. Justificou-se o estudo devido à elevação nos custos de produção agrícola e às limitações internas no fornecimento de insumos a montante. Para tanto, empregaram-se dados secundários oficiais e análises gráficas e econométricas que identificaram quais os elementos com maior nível de prioridade para os plantadores de soja e milho do Brasil. Os resultados apontaram que todos os componentes da formulação NPK (nitrogenados, fosfatados e potássios) importados se correlacionam com a produção e produtividade dos grãos em estudo. Nesse contexto, destacou-se a ureia, da qual a Petrobras era um dos fornecedores até 2015. Portanto, a mitigação da subordinação estrangeira no agronegócio brasileiro, passa, a princípio, pela reformulação do setor petroquímico nacional.
Abstract: Recent armed conflicts in Ukraine have caused negative effects on Brazilian agribusiness. Fertilizer supply has been strongly dependent on imported products, focus of this research. Increased costs of national food production due to shortage of national fertilizer production were the main motives for this paper. Data was obtained by governmental institutions and submitted to visual and econometric analysis. It was intended to identify which fertilizer inputs have been crucial for soy and maize producers in Brazil. The results suggested that all elements of NPK (nitrogenous, phosphate, and potassium) were correlated to production and profitability. Furthermore, urea is a core input which Petrobras produced until 2015. In conclusion, the mitigation of external dependence on Brazilian agribusiness requires a reframing of national petrochemical industry.
ĐẶC ĐIỂM LÂM SÀNG VÀ KẾT QUẢ ĐIỀU TRỊ BỆNH NHÂN SAU NGỪNG TUẦN HOÀN NGOẠI VIỆN TẠI KHOA CẤP CỨU BỆNH VIỆN BẠCH MAI
Authors: Nguyễn Anh Tuấn , Nguyễn Quốc Linh 
Published: March 2023

Mục tiêu: Nhận xét một số đặc điểm lâm sàng và kết quả điều trị bệnh nhân sau ngừng tuần hoàn ngoại viện. Đối tượng: 35 bệnh nhân (BN) hôn mê sau ngừng tuần hoàn được điều trị tại khoa cấp cứu Bệnh viện Bạch Mai từ tháng 8/2016 đến tháng 8/2017. Phương pháp nghiên cứu: mô tả tiến cứu. Bệnh nhân được đánh giá lâm sàng thời điểm nhập khoa và ghi nhận kết cục thần kinh thời điểm ra viện. Các biến định lượng được trình bày theo giá trị trung bình và độ lệch chuẩn; sử dụng các test tham số cho biến phân bố chuẩn và test phi tham số cho biến phân bố không chuẩn; sự khác biệt có ý nghĩa thống kê với p < 0,05. Các biến định tính được trình bày theo tỷ lệ phần trăm (%), sự khác biệt có ý nghĩa thống kê với p < 0,05. Kết quả: Tỉ lệ BN được hồi sức tim phổi tại hiện trường là 5.7%; Thời gian gian từ lúc biến cố ngừng tim đến lúc được hồi sức tim phổi trung bình là 10 phút, không có sự khác biệt về khoảng thời gian này giữa nhóm sống và nhóm tử vong; Tỉ lệ tử vong của các BN hôn mê sau ngừng tuần hoàn là 45.7%; Thời gian hồi sức tim phổi ≥ 28 phút là yếu tố tiên lượng tử vong cao với ROC = 0.755, p = 0.01 (CI95% 0.597 – 0.913); Tỷ lệ BN hôn mê Glasgow < 9 điểm tại thời điểm kết thúc điều trị tại khoa là 68.4%; 15.8% BN kết thúc điều trị với điểm Glasgow > 13; 60% BN có điểm Glasgow kết thúc điều trị từ 9 – 15 điểm còn phản xạ giác mạc thời điểm nhập viện. Kết luận: Tỉ lệ hồi sinh tim phổi tại hiện trường thấp, khoảng thời gian hồi sinh tim phổi cho đến khi có tuần hoàn trở lại dài là yếu tố tiên lượng tử vong cao. Còn phản xạ giác mạc thời điểm nhập viện có tiên lượng kết cục thần kinh tốt.
PERCEPCIA SUBURBANIZAČNÉHO PROCESU V POHRANIČNOM REGIÓNE BRATISLAVY A JEHO POTENCIÁL
Authors: Czafík Michal , Tóthová Zuzana 
Published: March 2023

Suburbanizačný proces v pohraničnom regióne Bratislavy mení charakter pôvodného územia dotknutých mestských častí. Nová výstavba narúša pôvodnú zástavbu, pôvodné obytné prostredie mení na nové. Tento fakt sa primárne dotýka autochtónneho obyvateľstva. Príspevok a realizovaný výskum odhalil vnímanie rozrastania mestských častí obyvateľstvom a odkryl potenciál pohraničného regiónu.
INVESTMENTS IN OHS DURING CONSTRUCTION AND THEIR EFFECTIVENESS
Authors: Madová Jana , Hulínová Zdenka 
Published: March 2023

Decision making on OHS investments influences on many factors. On one hand it is necessary to keep the legislation requirements directly related to preventive protection of employees. On the other hand the decision on keeping or failing to comply the rules also brings possible costs for recovery of damages from occupational accidents. The basic assumption, which is the nature of this article is hypothesis, if it is worth for companies to invest in preventive protection of workers and what is the limit, in which this type of protection is effective.
Duration and intensity of occupational lifting and risk of long-term sickness absence: Prospective cohort study with register follow-up among 45 000 workers
Authors: Bláfoss Rúni , Skovlund Sebastian Venge , Skals Sebastian , Sundstrup Emil , López-Bueno Rubén , Calatayud Joaquin , Andersen Lars Louis 
Published: March 2023

OBJECTIVE: This study aimed to investigate the prospective association of lifting duration and lifting load with the risk of long-term sickness absence (LTSA).
METHODS: We followed manual workers with occupational lifting (N=45 346) from the Work Environment and Health in Denmark Study (2012–2018) for two years in a high-quality national register on social transfer payments (DREAM). Cox regressions with model-assisted weights were employed to estimate the risk of LTSA from lifting duration and loads.
RESULTS: During follow-up, 9.6% of the workers had an episode of LTSA. Compared to workers with seldom lifting (reference), workers lifting ½ and ¾ of the workday had increased risk of LTSA [hazard ratios (HR) of 1.36 [95% confidence interval (CI) 1.20–1.56] and 1.22 (95% CI 1.07–1.39)], respectively. Lifting load showed a positive exposure–response association with LTSA (trend test, P<0.01), with HR for lifting 5–15, 16–29, and ≥30 kg at 1.11 (95% CI 1.02–1.22), 1.17 (95% CI 1.03–1.34), and 1.29 (95% CI 1.11–1.50), respectively. Age-stratified analyses showed increased risk of LTSA among workers ≥50 years with a high proportion of work-related lifting compared to their younger counterparts.
CONCLUSIONS: Occupational lifting for ½ the workday increased the risk of LTSA, while higher occupational lifting load exacerbated this risk in an exposure–response manner. The study underscores the importance of reducing both lifting duration and loads for prevention of LTSA at the workplace, especially among older workers.
Marketing + Medicine: Using Marketing Theory to Improve Patient Choices and Outcomes
Authors: Wood Stacy 
Published: March 2023

Marketing (as an academic field and as a practice) is often misunderstood by those promoting important innovations in the sciences and healthcare. In this talk, we will discuss how marketing theory is critically useful to the future of healthcare delivery and describe its recent successes in Covid-19 vaccination efforts. How do we encourage patients to adopt healthy new habits or adhere to new treatments? How do we communicate with large, diverse, and changing populations? How do we leverage the benefits of new technologies for patient engagement and avoid the pitfalls of those same technologies? Join us to learn the latest tools to guide healthy choices by understanding key consumer behaviour theories of how people choose and live with the consequences. The presentation will be followed by a workshop on the same topic at 1.30 pm in room 507- G080. This is an initiative supported by the University of Auckland Business School, the University of Auckland School of Population Health and the University of Canterbury Business School.To join online, please enter the following Zoom link into your browser:
https://auckland.zoom.us/j/95125034110?pwd=WUNNY2tlQlZxTUFSQUhLMTRDS0JRZz09
Meeting ID: 951 2503 4110 - Passcode: 411408
Ruskin Bond as a writer of short stories
Authors: Dr Kiritsinh P. Thakor  
Published: March 2023

This paper focuses on the view of ‘Ruskin Bond as writer of short stories’. In the modern age, the short stories highly impressed to the whole world. It is a highly complex form of literature and it has considered technically today, has been a very challenging form of literature. A short story is a type of prose fiction, which has grown up beside the fiction, and it has its own value and recognized place in literature today. Ruskin Bond is known internationally as one of India's most prolific writers in English for children, adults and young adults. His short stories are well-finished and integrated works of art in literature. His plots are not well constructed but his characters are appearing to be the living women and men to the nature. Most of his stories depend upon the characters and His work provides an insight or outside into universal themes such as the tension between present and past, culture elements, city life versus rural values, the dignity of ordinary folk song, preservation of the environment, and the living in harmony with nature.
Comparative/Historical Poetics in an Age of Cultural Studies
Authors: Shaytanov Igor 
Published: March 2023

ABSTRACT“Comparative poetics” does not belong to the set of established terms. It was introduced by Earl Miner (1990) and might have heralded an ambitious project if not immediately undermined by the subtitle “An Intercultural Essay on Theories of Literature.” It did not take long to find that poetics did not easily agree with cultural studies as they were proposed. The word, reduced to a sign and viewed as a function, was cut off from its poetic significance. In search for a new poetics, a special interest has been recently demonstrated toward “historical poetics” only vaguely heard of before thanks to the eminent Russian scholars (the Formalists, Bakhtin, and Propp) but still less known in its original form worked out by Alexander Veselovsky. His magnum opus, unfinished by the author, may serve as a guide in our search for method to restore the study of verbal art as poetics of world literature.
Hasta ve Yakınlarının Bakış Açısıyla COVID -19 Pandemi Sürecinde Acil Servise Başvuru Yapmak: “COVID-19’a Bir Adım Daha Yakın Olmak”
Authors: ÇETİNKAYA Aynur , YILMAZ Emel , CENGİZ Tuğba , HELVACI Duygu 
Published: March 2023

Amaç: Bu çalışmada amaç, COVID-19 pandemi sürecinde acil servise başvuru yapan hasta ve yakınlarının acil servis algı ve deneyimlerini betimlemektir.
Materyal ve Metot: Araştırma, nitel yaklaşıma dayalı içerik analizi ile yürütülmüştür. Çalışma Türkiye'nin batısındaki bir eğitim araştırma hastanesinin acil servisinde Haziran-Aralık 2021 tarihleri arasında yürütülmüştür. Amaçlı örnekleme yönteminden birisi olan ölçüt örnekleme yöntemi ile belirlenmiş 77 hasta ve yakını ile görüşülmüştür. Çalışma grubuna acil servise başvuru yapan ve araştırmaya katılmaya gönüllü olan hasta ve yakınları dahil edilmiştir. Veriler hasta ve yakınlarının sosyo demografik özelliklerini içeren sekiz soruluk tanıtıcı özellikleri içeren bilgi formu ve alanyazın doğrultusunda oluşturulan yarı yapılandırılmış açık uçlu 11 sorudan oluşan veri toplama formu ile toplanmıştır. Verilerin analizinde NVIVO 12 Pro programı kullanılmıştır. Tematik analiz verilerin değerlendirilmesinde kullanılmıştır.
Bulgular: COVID-19 pandemisinde acil servise başvuru yapan hasta ve yakınları ile yürütülmüş nitel soru çözümlemesine dayalı bu araştırmada dört kategoriye ulaşılmıştır. Bunlar en çok atıf alandan en aza doğru: COVID -19’a bir adım daha yakın (f:412), Risk almaya değmez (f:260), Korkulacak bir şey yok (f:121) ve Mecburiyet algısı (f:104) dır.
Sonuç: Araştırma sonucunda COVID-19 sürecinde acil serviste başvuran hasta ve yakınlarının mecburiyetten dolayı hastaneye başvurduğu, bu sırada korku, endişe, tedirginlik yaşadığı ve bir an önce acil servisten kurtulmak istedikleri saptanmıştır. Hasta ve yakınları acil servise başvuruyu ertelemeye bağlı oluşabilecek yaşamı tehdit eden durumlara yönelik toplumun farkındalığının arttırılması, bu konuda gerekli eğitimlerin verilmesi, sosyal medya araçları ve kamu spotları gibi kaynaklardan yararlanılması önerilmektedir.