bluuebunny/crossref_metadata_2025_split huggingface dataset:
Design and Implementation of the Diabetes Impact Project: A Multisector Partnership to Reduce Diabetes Burden in Indianapolis Communities
Authors: Staten Lisa K. , Weathers Tess D. , Nicholas Celeste , Grain Tedd , Haut Dawn P. , Duckett-Brown Patrice , Halverson Paul K. , Caine Virginia 
Published: July 2023

Context:
Community-level health disparities have not arisen suddenly but are the result of long-term systemic inequities. This article describes the design and implementation of a community-engaged multisector partnership to address health disparities by reducing the diabetes burden in 3 Indianapolis communities through the implementation of evidence-based strategies across the prevention continuum.

Program:
The project has 5 foundational design principles: engage partners from multiple sectors to address community health, focus on geographic communities most affected by the health disparity, practice authentic community engagement, commit for the long term, and utilize a holistic approach spanning the prevention continuum.

Implementation:
The design principles are incorporated into the following project components in each community: (1) health system community health workers (hCHWs), (2) neighborhood CHWs (nCHWs), (3) community health promotion initiatives, and (4) resident steering committees, as well as a backbone organization responsible for overall coordination, project communication, evaluation, and partnership coordination.

Evaluation:
This complex multilevel intervention is being evaluated using data sources and methodologies suited to each project component and its purpose overall. Each component is being evaluated independently and included holistically to measure the impact of the project on the health and culture of health in the communities. Key Performance Indicators were established upon project initiation as our common metrics for the partnership. Because complex interventions aiming at population-level change take time, we evaluate Diabetes Impact Project—Indianapolis Neighborhoods (DIP-IN), assuming its impact will take many years to achieve.

Discussion:
Health disparities such as the diabetes prevalence in project communities have not arisen suddenly but are the result of long-term systemic inequities. This complex issue requires a complex holistic solution with long-term commitment, trusted partnerships, and investment from diverse sectors as seen in this project. Implications for policy and practice include the need to identify stable funding mechanisms to support these types of holistic approaches.
Relationship Between Handgrip Strength and Pulmonary Function, Respiratory Muscle Strength, and Cardiopulmonary Fitness in Community-Dwelling Older Adults
Authors: Li Chi , Hsu Miao-Ju 
Published: July 2023

Background:
This study explored the relationship between handgrip strength (HGS) and pulmonary function, respiratory muscle strength, and cardiopulmonary endurance in older adults.

Methods:
We recruited 128 community-dwelling older adults. Correlations between HGS, pulmonary function parameters, respiratory muscle strength, and cardiopulmonary endurance were analyzed.

Results:
Forced vital capacity (r = 0.180, P < .05), maximum voluntary ventilation (r = 0.180, P < .05), and 2-minute step test (r = 0.204, P < .05) were weakly correlated with HGS. Maximum inspiratory pressure (MIP) and maximum expiratory pressure (MEP) had moderate correlations with HGS (r = 0.431 for MIP, 0.492 for MEP, P < .001).

Conclusion:
HGS was correlated with pulmonary function, respiratory muscle strength, and cardiorespiratory endurance.
Validity, Reliability, and Responsiveness of the Dubousset Functional Test in Older Adults
Authors: Abit Kocaman Ayşe , Sertel Meral , Aydoğan Arslan Saniye 
Published: July 2023

Objective:
The aim of our study was to examine the test-retest reliability and validity of the Dubousset Functional Test (DFT) in older adults.

Methods:
The DFT, 3-m Backward Walk Test (3MBWT), Timed Up and Go (TUG) test, and Tinetti Performance-Oriented Mobility Assessment (POMA) were administered to 80 older adults.

Results:
Intraclass correlation coefficient (ICC) values were between 0.819 and 0.965 (excellent agreement). A correlation was found between DFT parameters and the TUG test, 3MBWT, and POMA scores. A low correlation was found between the TUG test and 3MBWT with the dual-task test; no correlation was determined between the POMA scores with the dual-task test.

Conclusion:
It was concluded that the DFT is a valid and reliable test for older adults.
Antecedents of yacht tourism participants’ satisfaction and word-of-mouth intention
Authors: Fotiadis Anestis , Rice John , Hiyasat Rund 
Published: July 2023

PurposeAs a contribution to current knowledge of luxury yachting, this study applies a theoretical discussion to explain how gratification, social motives, financial risk and status quo interact to predict satisfaction and word-of-mouth intentions among luxury yachting travelers. Additionally, gender moderating effects on antecedent factors of satisfaction were examined.Design/methodology/approachA questionnaire was distributed in the United Arab Emirates, and 228 valid questionnaires were received which were analyzed with AMOS structural equation modeling.FindingsThe results of this study were analyzed using structural equation modeling. According to the results, factors such as gratification, social motives, and the status quo are significantly associated with satisfaction. The degree of satisfaction is directly related to the likelihood of spreading word of mouth. Result differences between males and females can be explained by moderating effects.Originality/valueThis is one of the first studies that examine the antecedents of luxury yachting to satisfaction and word of mouth impact.
Modulation of the activation of endothelial nitric oxide synthase and nitrosative stress biomarkers by aspirin triggered lipoxins: A possible mechanism of action of aspirin in the antiphospholipid syndrome
Authors: Granada‐Gómez Manuel , Velásquez‐Berrío Manuela , Molina Carolina Rúa , Martín Sebastián San , Escudero Carlos , Alvarez Angela M. , Cadavid Angela P. 
Published: July 2023

AbstractProblemAntiphospholipid syndrome (APS) is characterized by the clinical manifestation of vascular thrombosis (VT) or pregnancy morbidity (PM) and antiphospholipid antibodies (aPL) that can modify the nitric oxide production. Low‐dose aspirin is used in the prevention and treatment of diverse alterations of pregnancy. One of the mechanisms of action of aspirin is to induce the production of aspirin‐triggered‐lipoxins (ATL). The aim of this study was to evaluate the modulatory effect of ATL over the activation of endothelial nitric oxide synthase (eNOS) and nitrosative stress biomarkers induced by aPL.MethodsWe used polyclonal IgG and sera from women with aPL and PM/VT or VT only, and from women with PM only and positive for non‐criteria aPL (SN‐OAPS). In these sera, biomarkers of nitrosative stress (nitrites and nitrotyrosine) were measured. The protein expression of nitrotyrosine and the phosphorylation of eNOS (at Ser1177) were estimated in human umbilical vein endothelial cells (HUVECs) stimulated with polyclonal IgG with or without ATL.ResultsWomen with SN‐OAPS showed increased circulating levels of nitrites and nitrotyrosine. Likewise, polyclonal IgG from either SN‐OAPS or VT patients stimulated nitrotyrosine expression in HUVECs. ATL decreased the nitrotyrosine expression induced by polyclonal IgG from the SN‐OAPS group. ATL also recovered the reduced eNOS phosphorylation at Ser1177 in HUVECs stimulated with polyclonal IgG from women with PM/VT or SN‐OAPS.ConclusionsIncreased nitrosative stress present in serum of women with SN‐OAPS is associated with IgG‐mediated impaired endothelial NO synthesis in endothelial cells. ATL prevent these cellular changes.
Predicting outcomes following short‐term ventricular assist device implant with the MELD‐XI score
Authors: Pidborochynski Tara , Bozso Sabin J. , Buchholz Holger , Freed Darren H. , MacArthur Roderick , Conway Jennifer 
Published: July 2023

AbstractBackgroundShort‐term continuous flow (STCF) ventricular assist devices (VADs) are utilized in adults with cardiogenic shock; however, mortality remains high. Previous studies have found that high pre‐operative MELD‐XI scores in durable VAD patients are associated with mortality. The use of the MELD‐XI score to predict outcomes in STCF‐VAD patients has not been explored. We sought to determine the relationship between MELD‐XI and outcomes in adults with STCF‐VADs.MethodsThis was a retrospective review of adults implanted with STCF‐VADs between 2009 and 2019. Receiver operating characteristic (ROC) analysis was performed to predict outcomes and Kaplan–Meier analysis was done to assess survival.ResultsSeventy‐nine patients were included with a median MELD‐XI score of 21.2 (IQR 13.5, 27.0). Patients with an unsuccessful wean from support (p < 0.001) or major post‐operative bleeding (p = 0.03) had significantly higher pre‐implant MELD‐XI scores. The optimal MELD‐XI cut‐point for mortality was 24.9 with 27.8 for major bleeding. Survival was worse among patients in the high‐risk MELD‐XI group, however, not statistically significant (p = 0.09). Prior ECMO support, but not MELD‐XI, was an independent predictor of unsuccessful wean (p = 0.03).ConclusionsPre‐operative MELD‐XI score was a moderate predictor of unsuccessful wean with limited utility in predicting bleeding in patients on STCF‐VAD support. This scoring system may be useful in the clinical setting for pre‐implant risk stratification and counseling among patients and outcomes.
Regulation of the ATP‐binding cassette transporters ABCB1, ABCG2 and ABCC5 by nuclear receptors in porcine blood–brain barrier endothelial cells
Authors: Ho Yu Siong , Torres‐Vergara Pablo , Penny Jeffrey 
Published: July 2023

AbstractBackground and PurposeBlood–brain barrier (BBB) ABCB1, ABCG2 and ABCC5 transporters influence central therapeutic drug distribution. Transporter expression is regulated by the NR3C1, NR1I3 and NR1I2 nuclear receptors, but their precise roles in brain are poorly understood. We investigated the effects of selective ligand‐based activation of NR3C1, NR1I3, NR1I2 and NR2B1 in porcine brain endothelial cells (PBECs).Experimental ApproachPrimary cultures of PBECs were exposed to NR3C1, NR1I3 and NR1I2 ligands and ABCB1, ABCG2 and ABCC5 transporter activities determined by measuring intracellular accumulation of fluorescent probes. Western blotting was used to determine the effects of receptor ligands on expression of ABCB1, ABCG2, ABCC5, NR1I2, NR1I3, NR3C1 and NR2B1. Fluorescent immunocytochemistry was employed to assess the effects of receptor ligands on the cellular localisation of NR1I2 and NR1I3.Key ResultsThe NR1I2 agonist rifampicin significantly up‐regulated ABCG2 activity, which is counteracted by co‐treatment with NR1I2 antagonist l‐sulforaphane. The NR1I3 agonist 6‐(4‐chlorophenyl)‐imidazo[2,1‐b]thiazole‐5‐carbaldehyde and inverse agonist meclizine significantly down‐regulated ABCB1, ABCG2 and ABCC5 activity. NR3C1 agonist dexamethasone significantly increased ABCB1, ABCG2 and ABCC5 activity and ABCG2 and ABCC5 protein expression, which was counteracted by co‐treatment with the NR3C1 antagonist mifepristone. This first study demonstrates that NR1I3 and NR3C1 regulate ABCC5 activity and protein expression in BBB endothelial cells.Conclusions and ImplicationsIn PBECs, expression of key ATP‐binding cassette (ABC) transporters and nuclear receptors is differentially regulated by NR1I3, NR1I2, NR3C1 and NR2B1. This will help to better understand the response of the BBB to physiological and pharmacological activation of nuclear receptors.
Maxillary sinus membrane elevation and coagulum compared with maxillary sinus floor augmentation and a composite graft: A 1‐year single‐blinded randomized controlled trial
Authors: Starch‐Jensen Thomas , Bruun Niels Henrik , Spin‐Neto Rubens 
Published: July 2023

AbstractObjectiveThe aim was to evaluate the 1‐year implant outcome and patient‐related outcome measures (PROMs) after maxillary sinus membrane elevation and coagulum (test) compared with maxillary sinus floor augmentation and a 1:1 ratio of autogenous bone graft from the buccal antrostomy and deproteinised porcine bone mineral (DPBM) (control).Materials and methodsForty patients (30 female, 10 male) with a mean age of 50 years (range 25–71 years) and an alveolar ridge height between 4 and 7 mm were randomly allocated to test or control. Outcome measures included survival of suprastructures and implants, implant stability quotient, health status of the peri‐implant tissue, peri‐implant marginal bone loss, frequency of complications and PROMs using Oral Health Impact Profile‐14 combined with questionnaires assessing patient's perception of the peri‐implant soft tissue, implant crown, function of the implant, and total implant treatment outcome using visual analogue scale. Mean differences were expressed with standard deviation and 95% confidence interval. Level of significance was 0.05.ResultsAll suprastructures and implants were well‐functioning after 1‐year of functional implant loading. No significant difference in any of the applied outcome measures was observed between test and control. Both treatments revealed high patient satisfaction scores and significant improvement in oral health‐related quality of life.ConclusionThere were no significant differences in implant outcome and PROMs between test and control, after 1‐year of functional implant loading. Neither of the treatments can therefore be considered better than the other. Thus, long‐term randomized controlled trials are needed before definitive conclusions can be provided about the two treatment modalities.
Impulsivity as key bridge symptoms in cross‐sectional and longitudinal networks of ADHD and ODD
Authors: Bansal Pevitr S. , Goh Patrick K. , Southward Matthew W. , Sizemore Yancey J. , Martel Michelle M. 
Published: July 2023

BackgroundImpulsivity is viewed as key to attention‐deficit/hyperactivity disorder (ADHD) and disruptive behavior disorders (DBD). Yet, to date, no work has provided an item‐level analysis in longitudinal samples across the critical developmental period from childhood into adolescence, despite prior work suggesting items exhibit differential relevance with respect to various types of impairment. The current study conducted a novel longitudinal network analysis of ADHD and oppositional defiant disorder (ODD) symptoms between childhood and adolescence, with the important applied prediction of social skills in adolescence.MethodsParticipants were 310 children over‐recruited for clinical ADHD issues followed longitudinally for six years in total with gold standard diagnostic procedures and parent and teacher ratings of symptoms and social outcomes.ResultsFindings from baseline, Year 3, and Year 6 suggested Difficulty waiting turn, Blurts, and Interrupts/intrudes were key bridge items across cross‐sectional and longitudinal parent‐reported DBD networks. Furthermore, shortened symptom lists incorporating these symptoms were stronger predictors of teacher‐rated social skills 5 years later compared to total DBD scores.ConclusionsSuch findings are consistent with the trait impulsivity theory of DBD and ADHD and may inform useful screening tools and personalized intervention targets for children at risk for DBD during adolescence.
Oxynoemacheilus marmaraensis, a new species from the Susurluk River, Türkiye (Teleostei: Nemacheilidae)
Authors: Turan Davut , Bayçelebi Esra , Kalaycı Gökhan 
Published: July 2023

AbstractOxynoemacheilus marmaraensis, new species, is restricted to the Susurluk River. It is distinguished from all the named species of Oxynoemacheilus in the northwestern Anatolian by the flank with a vermiculate pattern and the presence of a suborbital groove in males, and no axillary lobe at the base of the pelvic fin. It also differs from the closest species, Oxynoemacheilus kentritensis, by having 58 nucleotide substitution sites. The genetic distance is 10.49% between O. marmaraensis and O. kentritensis. Phylogenetic analyses and species delimitation tests (Poisson tree processes and assemble species by automatic partitioning) support the validity of O. marmaraensis as a distinct species.
Development of a Fitness Surveillance System to Track and Evaluate Obesity in North Idaho
Authors: Egan Cate A. , Mercia Christopher B. , Bond Laura , Vella Chantal A. , Paul David R. 
Published: July 2023

ABSTRACTBACKGROUNDInternationally 18% of youth are obese. Fitness testing can be used to establish fitness surveillance, which can inform policy and targeted interventions aimed at addressing obesity. The purpose of this study was to estimate the prevalence of overweight, obesity, and low fitness in Idaho school‐aged youth through a pilot study.METHODSA convenience sample of 13 teachers from 11 north Idaho rural schools collected FitnessGram fitness data: body composition (body mass index [BMI]), aerobic capacity (Progressive Aerobic Cardiovascular Endurance Run [PACER] test), muscular endurance (curl up), strength (pushup), and flexibility (sit and reach).RESULTSA total of 761 students (aged 9‐18 years) from grades 3&5, 7, and 9 to 12 participated in the study. Approximately 24% of 3&5 and 22% of 7th, and 12% of 9 to 12th‐grade students were categorized as Needs Improvement/Health Risk by FitnessGram standards for BMI. Similarly, approximately 25% of 3&5, and 22% of 7 and 9 to 12th‐grade students were considered Needs Improvement/Health Risk for PACER.IMPLICATIONS FOR SCHOOL HEALTH POLICY, PRACTICE, AND EQUITYResults from fitness testing can provide school and public health representatives with a “needs assessment” of student health that can be used to help develop policies and practices to improve student health and wellbeing.CONCLUSIONSThis study provides a model for statewide annual fitness testing surveillance and reporting within K‐12 public school physical education classrooms.
Angiopoietin‐2 Promotes Mechanical Stress‐induced Extracellular Matrix Degradation in Annulus Fibrosus Via the HIF‐1α/NF‐κB Signaling Pathway
Authors: Ao Xiang , Li Yuan , Jiang Tao , Li Chenglong , Lian Zhengnan , Wang Liang , Zhang Zhongmin , Huang Minjun 
Published: July 2023

ObjectiveMechanical stress is an important risk factor for intervertebral disc degeneration (IVDD). Angiopoietin‐2 (ANG‐2) is regulated by mechanical stress and is widely involved in the regulation of extracellular matrix metabolism. In addition, the signaling cascade between HIF‐1α and NF‐κB is critical in matrix degradation. This study aims to investigate the role and molecular mechanism of ANG‐2 in regulating the degeneration of annulus fibrosus (AF) through the HIF‐1α/NF‐κB signaling pathway.MethodsThe bipedal standing mice IVDD model was constructed, and histological experiments were used to evaluate the degree of IVDD and the expression of ANG‐2 in the AF. Mouse primary AF cells were extracted in vitro and subjected to mechanical stretching experiments. Western blot assay was used to detect the effect of mechanical stress on ANG‐2, and the role of the ANG‐2‐mediated HIF‐1α/NF‐κB pathway in matrix degradation. In addition, the effect of inhibiting ANG‐2 expression by siRNA or monoclonal antibody on delaying IVDD was investigated at in vitro and in vivo levels. One‐way ANOVA with the least significant difference method was used for pairwise comparison of the groups with homogeneous variance, and Dunnett's method was used to compare the groups with heterogeneous variance.ResultsIn IVDD, the expressions of catabolic biomarkers (mmp‐13, ADAMTS‐4) and ANG‐2 were significantly increased in AF. In addition, p65 expression was increased while HIF‐1α expression was significantly decreased. The results of western blot assay showed mechanical stress significantly up‐regulated the expression of ANG‐2 in AF cells, and promoted matrix degradation by regulating the activity of HIF‐1α/NF‐κB pathway. Exogenous addition of Bay117082 and CoCl2 inhibited matrix degradation caused by mechanical stress. Moreover, injection of neutralizing antibody or treatment with siRNA to inhibit the expression of ANG‐2 improved the matrix metabolism of AF and inhibited IVDD progression by regulating the HIF‐1α/NF‐κB signaling pathway.ConclusionIn IVDD, mechanical stress could regulate the HIF‐1α/NF‐κB signaling pathway and matrix degradation by mediating ANG‐2 expression in AF degeneration.
Mutagenicity assessment of high‐power 1.6‐THz pulse laser radiation
Authors: Shirato Midori , Takida Yuma , Kanno Taro , Matsuura Hiroshi , Niwano Yoshimi , Minamide Hiroaki , Nakamura Keisuke 
Published: July 2023

AbstractThe effect of terahertz (THz) radiation has been studied in medicine. However, there is a lack of scientific information regarding its possible mutagenicity. Therefore, the present study aimed to assess the mutagenicity of 1.6 THz laser irradiation. The Ames test was conducted using five bacterial tester strains. The bacteria were subjected to (i) 1.6 THz laser irradiation at 3.8 mW/cm2 for 60 min using a tabletop THz pulse laser system, (ii) ultraviolet irradiation, (iii) treatment with positive control chemicals (positive control) or (iv) treatment with the solvent used in the positive control (negative control). After treatment, the bacterial suspensions were cultured on minimal glucose agar to determine the number of revertant colonies. In addition, the comet assay was performed using fibroblasts (V79) to assess possible DNA damage caused by the THz laser irradiation. The Ames test demonstrated that the THz laser irradiation did not increase the number of revertant colonies compared to that in the negative control group, whereas the ultraviolet irradiation and positive control treatment increased the number of revertant colonies. Thus, 1.6 THz laser irradiation is unlikely to be mutagenic. The comet assay additionally suggests that the THz laser irradiation unlikely induce cellular DNA damage.
Two kinds of curiosity
Authors: Dover Daniela 
Published: July 2023

AbstractLeading philosophical models of curiosity represent it as a desiderative attitude whose content is a question, and which is satisfied by knowledge of the answer to that question. I argue that these models do not capture the distinctive character of a form of curiosity that I call 'erotic curiosity'. Erotic curiosity addresses itself not to a question but to an object whose significance for the inquirer is affective as well as epistemic. This form of curiosity is best understood by analogy to erotic love as theorized by Plato in the Symposium.