bluuebunny/crossref_metadata_2025_split huggingface dataset:
Digital delivery of behavioural activation therapy to overcome depression and facilitate social and economic transitions of adolescents in South Africa (the DoBAt study): protocol for a pilot randomised controlled trial
Authors: Moffett Bianca D , Pozuelo Julia R , van Heerden Alastair , O'Mahen Heather A , Craske Michelle , Sodi Tholene , Lund Crick , Orkin Kate , Kilford Emma J , Blakemore Sarah-Jayne , Mahmud Mahreen , Musenge Eustasius , Davis Meghan , Makhanya Zamakhanya , Baloyi Tlangelani , Mahlangu Daniel , Chierchia Gabriele , Fielmann Sophie L , Gómez-Olivé F Xavier , Valodia Imraan , Tollman Stephen , Kahn Kathleen , Stein Alan 
Published: December 2022

IntroductionScalable psychological treatments to address depression among adolescents are urgently needed. This is particularly relevant to low-income and middle-income countries where 90% of the world’s adolescents live. While digital delivery of behavioural activation (BA) presents a promising solution, its feasibility, acceptability and effectiveness among adolescents in an African context remain to be shown.Methods and analysisThis study is a two-arm single-blind individual-level randomised controlled pilot trial to assess the feasibility, acceptability and initial efficacy of digitally delivered BA therapy among adolescents with depression. The intervention has been coproduced with adolescents at the study site. The study is based in the rural northeast of South Africa in the Bushbuckridge subdistrict of Mpumalanga province. A total of 200 adolescents with symptoms of mild to moderately severe depression on the Patient Health Questionnaire Adolescent Version will be recruited (1:1 allocation ratio). The treatment group will receive BA therapy via a smartphone application (the Kuamsha app) supported by trained peer mentors. The control group will receive an enhanced standard of care. The feasibility and acceptability of the intervention will be evaluated using a mixed methods design, and signals of the initial efficacy of the intervention in reducing symptoms of depression will be determined on an intention-to-treat basis. Secondary objectives are to pilot a range of cognitive, mental health, risky behaviour and socioeconomic measures; and to collect descriptive data on the feasibility of trial procedures to inform the development of a further larger trial.Ethics and disseminationThis study has been approved by the University of the Witwatersrand Human Research Ethics Committee (MED20-05-011) and the Oxford Tropical Research Ethics Committee (OxTREC 34-20). Study findings will be published in scientific open access peer-reviewed journals, presented at scientific conferences and communicated to participants, their caregivers, public sector officials and other relevant stakeholders.Trial registration numbersThis trial was registered on 19 November 2020 with the South African National Clinical Trials Registry (DOH-27-112020-5741) and the Pan African Clinical Trials Registry (PACTR202206574814636).
Genetic and genomic nursing competency among nurses in tertiary general hospitals and cancer hospitals in mainland China: a nationwide survey
Authors: Zhao Xiaomin , LI Xuying , Liu Yi , Calzone Kathleen , Xu Juan , Xiao Xueling , Wang Honghong 
Published: December 2022

ObjectivesTo explore genetic/genomic nursing competency and associated factors among nurses from tertiary general and specialist cancer hospitals in mainland China and compare the competencies of nurses from the two types of hospitals.Design and settingA cross-sectional survey was conducted from November 2019 to January 2020, wherein 2118 nurses were recruited from 8 tertiary general hospitals and 4 cancer hospitals in mainland China. We distributed electronic questionnaires to collect data on nurses’ demographics, work-related variables and genomic nursing competency.Participants2118 nurses were recruited via a three-stage stratified cluster sampling method.ResultsMore than half (59.1%, 1252/2118) of the participants reported that their curriculum included genetics/genomics content. The mean nurses’ genomic knowledge score was 8.30/12 (95% CI=8.21 to 8.39). Only 5.4% had always collected a complete family history in the past 3 months. Compared with general hospital nurses, slightly more cancer hospital nurses (75.6% vs 70.6%, p=0.010) recognised the importance of genomics, while there was no significant difference in the knowledge scores (8.38 vs 8.21, p>0.05). Gender (β=0.06, p=0.005), years of clinical nursing (β=−0.07, p=0.002), initial level of nursing education (β=0.10, p<0.001), membership of the Chinese Nursing Association (β=0.06, p=0.004), whether their curriculum included genetics/genomics content (β=0.08, p=0.001) and attitude towards becoming more educated in genetics/genomics (β=0.25, p<0.001) were significantly associated with the nurses’ genomic knowledge score.ConclusionThe levels of genomic knowledge among mainland Chinese nurses in tertiary hospitals were moderate. The overall genomic competency of cancer hospital nurses was comparable to that of general hospital nurses. Further genomic training is needed for nurses in China to increase their genomic competency and accelerate the integration of genomics into nursing practice.
Cohort Profile:The Danish National Cohort Study of Effectiveness and Safety of SARS-CoV-2 vaccines (ENFORCE)
Authors: Stærke Nina Breinholt , Reekie Joanne , Johansen Isik S , Nielsen Henrik , Benfield Thomas , Wiese Lothar , Søgaard Ole S , Tolstrup Martin , Iversen Kasper Karmark , Tarp Britta , Larsen Fredrikke Dam , Larsen Lykke , Lindvig Susan Olaf , Holden Inge Kristine , Iversen Mette Brouw , Knudsen Lene Surland , Fogh Kamille , Jakobsen Marie Louise , Traytel Anna Katrin , Ostergaard Lars , Lundgren Jens 
Published: December 2022

PurposeThe ENFORCE cohort is a national Danish prospective cohort of adults who received a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine as part of the Danish National SARS-CoV-2 vaccination programme. It was designed to investigate the long-term effectiveness, safety and durability of SARS-CoV-2 vaccines used in Denmark.ParticipantsA total of 6943 adults scheduled to receive a SARS-CoV-2 vaccine in the Danish COVID-19 vaccination programme were enrolled in the study prior to their first vaccination. Participants will be followed for a total of 2 years with five predetermined follow-up visits and additional visits in relation to any booster vaccination. Serology measurements are performed after each study visit. T-cell immunity is evaluated at each study visit for a subgroup of 699 participants. Safety information is collected from participants at visits following each vaccination. Data on hospital admissions, diagnoses, deaths and SARS-CoV-2 PCR results are collected from national registries throughout the study period. The median age of participants was 64 years (IQR 53–75), 56.6% were women and 23% were individuals with an increased risk of a serious course of COVID-19. A total of 340 (4.9%) participants tested positive for SARS-CoV-2 spike IgG at baseline.Findings to dateResults have been published on risk factors for humoral hyporesponsiveness and non-durable response to SARS-CoV-2 vaccination, the risk of breakthrough infections at different levels of SARS-CoV-2 spike IgG by viral variant and on the antibody neutralising capacity against different SARS-CoV-2 variants following primary and booster vaccinations.Future plansThe ENFORCE cohort will continuously generate studies investigating immunological response, effectiveness, safety and durability of the SARS-CoV-2 vaccines.Trial registration numberNCT04760132.
Incisional hernia prevention: risk–benefit from a patient perspective (INVITE) – protocol for a single-centre, mixed-methods, cross-sectional study aiming to determine if using prophylactic mesh in incisional hernia prevention is acceptable to patients
Authors: Smith Laurie , Meggy Alun , Watts Tessa , Knight Laura , Torkington Jared , Cornish Julie 
Published: December 2022

IntroductionIncisional hernia (IH) is a common complication of abdominal surgery affecting between 10% and 20% of patients and is associated with significant morbidity along with cost to the National Health Service. With high recurrence rates following repair, focus must be on prevention of IH rather than cure. There is an increasing evidence that patients at high risk of developing IH may benefit from prophylactic mesh placement during their index operation. With recent controversy surrounding the use of mesh in the UK, however, there is little understanding of whether this intervention would be acceptable to patients.Methods and analysisINVITE is a mixed-methods, cross-sectional study to explore patient perceptions of the use of mesh as prophylaxis to prevent IH. Patients with and without IH who have undergone colorectal surgery between 2017 and 2020 in a single UK health-board will be approached to participate. 120 participants will be asked to complete a questionnaire and a subgroup of 24 participants will be invited to semistructured interviews. The primary outcome is to assess the acceptability of prophylactic mesh to patients. Secondary outcomes include understanding patients’ knowledge of IH, and factors that may influence or alter the acceptability of mesh. Questionnaires have been developed using a 5-point Likert scale to allow quantitative analysis. Qualitative analysis of interviews will be conducted using NVivo software and thematic analysis. Data will be presented using the Journal Article Reporting Standards for mixed-methods research.Ethics and disseminationEthical approval has been granted by REC Wales (22/PR/0678), and the study is currently in setup. All participants will be required to provide informed consent prior to their participation in the study. We plan to report the results of the study in peer-reviewed scientific and medical journals and via presentations at scientific meetings. Results from this study will aid the design of interventional trials using prophylactic mesh.Trial registration numberNCT05384600.
Advanced heart failure: parenteral diuretics for breathlessness and peripheral oedema – systematic review
Authors: Hughes Alex , Oluyase Adejoke O , Below Natalie , Bajwah Sabrina 
Published: December 2022

BackgroundAdvanced heart failure patients suffer with breathlessness and peripheral oedema, which are frequently treated with parenteral diuretics despite limited evidence.AimTo analyse the effectiveness of parenteral diuretics on breathlessness and peripheral oedema in advanced heart failure patients.MethodsWe searched Embase, MEDLINE(R), PsycINFO, CINAHL and CENTRAL from their respective inceptions to 2021, and performed handsearching, citation searching and grey literature search; limited to English publications. Selection criteria included parenteral (intravenous/subcutaneous) diuretic administration in advanced heart failure patients (New York Heart Association class III–IV). Two authors independently assessed articles for inclusion; one author extracted data. Data were synthesised through narrative synthesis or meta-analysed as appropriate.Results4646 records were screened; 6 trials (384 participants) were included. All were randomised controlled trials (RCTs) comparing intravenous continuous furosemide infusion (CFI) versus intravenous bolus furosemide infusion (BFI). Improvement in breathlessness and peripheral oedema (two studies, n=161, OR 2.80, 95% CI 1.45 to 5.40; I2=0%), and increase in urine output (four studies, n=234, mean difference, MD 344.76, 95% CI 132.87 to 556.64; I2=44%), were statistically significant in favour of CFI. Significantly lower serum potassium was found in BFI compared with CFI (three studies, n=194, MD −0.20, 95% CI −0.38 to −0.01; I2=0%). There was no difference between CFI and BFI on reduction in weight, renal function or length of hospital stay.ConclusionsCFI appears to improve congestion in advanced heart failure patients in the short term. Available data came from small trials. Larger, prospective RCTs are recommended to address the evidence gap.
ДОСЛІДЖЕННЯ ГОСТРОЇ ТОКСИЧНОСТІ ПЕСАРІЇВ «ЛАКТОВАГІН»
Authors: Aleinyk S. L. , Polova Z. M. 
Published: December 2022

Мета. Дослідити гостру токсичність песаріїв під умовною назвою «Лактовагін» на лабораторних тваринах.
Матеріали і методи. Об’єкт дослідження: песарії «Лактовагін», що містять субстанцію Lactobacillus IMB B-7280 з пробіотичною активністю, та можуть використовуватись для лікування та профілактики дисбіотичних порушень у жінок. Дослідження гострої токсичності проводили на мишах-самицях лінії BALB/c при однократному застосуванні розробленого лікарського засобу при двох шляхах введення: інтравагінальному та внутрішньошлунковому. Статистичну обробку результатів здійснювали за допомогою ліцензійного програмного забезпечення MedStat v.5.2. Відмінності показників вважали статистично значущими при р<0,05.
Результати й обговорення. Основними критеріями визначення токсичної дії препарату були загибель тварин, прояви інтоксикації, зниження індивідуальної та групової маси тварин порівняно з вихідною масою, що не спостерігали під час проведення даного експерименту. Під час щоденних оглядів тварин після однократного введення песаріїв «Лактовагін» не виявлено жодних патологічних поведінкових та фізіологічних проявів. Приріст індивідуальної та групової маси мишей був фізіологічним на рівні 3,5–4,1 % для дослідних груп, 2,8 % – для інтактного контролю. Наприкінці експерименту тварини підлягали евтаназії з метою проведення патоморфологічних досліджень, при проведенні яких не спостерігали патологічні зміни внутрішніх органів та головного мозку. Статистично значущих відмінностей між коефіцієнтами маси внутрішніх органів мишей-самиць для різних груп не виявлено.
Висновки. З огляду на отримані дані після проведення експерименту, а саме: летальність мишей на рівні 0 %, позитивну динаміку приросту індивідуальної та групової маси тіла лабораторних тварин, відсутність ознак патології при проведенні патоморфологіних досліджень, можна припустити, що песарії «Лактовагін», що містять субстанцію Lactobacillus casei IMB B-7280 з пробіотичною активністю, є відносно безпечними та нешкідливими.
New Classification for the Combined Assessment of the Fractional Excretion of Urea Nitrogen and Estimated Plasma Volume Status in Acute Heart Failure
Authors: Nogi Kazutaka , Ueda Tomoya , Nakamura Takuya , Nogi Maki , Ishihara Satomi , Nakada Yasuki , Hashimoto Yukihiro , Nakagawa Hitoshi , Nishida Taku , Seno Ayako , Onoue Kenji , Watanabe Makoto , Saito Yoshihiko 
Published: December 2022

Background
The fractional excretion of urea nitrogen (FEUN) has been used as a renal blood flow index related to cardiac output, and the estimated plasma volume status (ePVS) as a body fluid volume index. However, the usefulness of their combination in acute decompensated heart failure (HF) management is unclear. We investigated the effect of 4 hemodynamic categories according to the high and low FEUN and ePVS values at discharge on the long‐term prognosis of patients with acute decompensated HF.

Methods and Results

Between April 2011 and December 2018, we retrospectively identified 466 patients with acute decompensated HF with FEUN and ePVS values at discharge. Primary end point was postdischarge all‐cause death. Secondary end points were (1) the composite of all‐cause death and HF readmission, and (2) HF readmission in a time‐to‐event analysis. The patients were divided into 4 groups according to the high/low FEUN (≥35%, <35%) and ePVS (>5.5%, ≤5.5%) values at discharge: high‐FEUN/low‐ePVS, high‐FEUN/high‐ePVS, low‐FEUN/low‐ePVS, and low‐FEUN/high‐ePVS groups. During a median follow‐up period of 28.1 months, there were 173 all‐cause deaths (37.1%), 83 cardiovascular deaths (17.8%), and 121 HF readmissions (26.0%). The Kaplan–Meier curve analysis showed that the high‐FEUN/low‐ePVS group had a better prognosis than the other groups (log‐rank test,
P
<0.001). In the multivariable Cox regression analysis, the low‐FEUN/high‐ePVS group had a higher mortality than the high‐FEUN/low‐ePVS group (hazard ratio, 2.92 [95% CIs, 1.73–4.92;
P
<0.001]).

Conclusions
The new classification of the 4 hemodynamic profiles using the FEUN and ePVS values may play an important role in improving outcomes in patients with stable acute decompensated HF.
Left Ventricular Apical Aneurysm in Fabry Disease: Implications for Clinical Significance and Risk Stratification
Authors: Chang Hao‐Chih , Kuo Ling , Sung Shih‐Hsien , Weng Ching‐Yao , Chen Chun‐Ku , Niu Dau‐Ming , Chen Shih‐Ann , Yu Wen‐Chung 
Published: December 2022

Background
A previously underrecognized phenotype of left ventricular apical aneurysm (LVAA) has been increasingly identified in Fabry disease. This study explored LVAA's clinical prevalence and its prognostic implications over a long‐term follow‐up.

Methods and Results

We retrospectively analyzed 268 consecutive patients with Fabry disease at a tertiary medical center. Patients with increased left ventricular mass index were recognized as having left ventricular hypertrophy (LVH). LVAA was identified using either echocardiography or cardiovascular magnetic resonance imaging. Two patients with ischemic LVAA were excluded. The primary end point was a composite of cardiovascular events, including heart failure hospitalization, sustained ventricular tachycardia, ischemic stroke, and all‐cause mortality. Of 266 enrolled patients, 105 (39.5%) had LVH (age 58.5±11.9 years, 48.6% men), and 11 (10.5%) had LVAA. Over 49.3±34.8 months of follow‐up, 25 patients with LVH experienced composite events, including 9 heart failure hospitalizations, 4 sustained ventricular tachycardia, 6 ischemic strokes, and 15 mortalities. In patients with LVH, those with LVAA had a significantly higher risk of composite events and lower event‐free survival than those without LVAA (8 [72.7%] versus 17 [18.1%], log‐rank
P
<0.001). LVAA was independently associated with an increased risk of composite events (hazard ratio, 3.59 [95% CI, 1.30–9.91];
P
=0.01) after adjusting for age, sex, advanced heart failure, renal function, dyslipidemia, atrial fibrillation, left ventricular ejection fraction, left ventricular diastolic function, and left ventricular mass index.

Conclusions
LVAA is present in approximately 10% of patients with Fabry disease and LVH. It is associated with an increased risk of adverse cardiovascular events and may necessitate aggressive treatment.
Droughts, Famines, and Chronicles: The 1780s Global Climatic
Anomalies in Highland Ethiopia
Authors: Gooding Philip 
Published: December 2022

Abstract
Climatological data suggest that the key driver of drought in Highland Ethiopia, and in the wider Indian Ocean World, during the early 1780s was an El Niño Southern Oscillation anomaly. Ethiopia during this period—an early decade in the zemene mesafint (1769–1855)—endured considerable political instability. The lack of documentary evidence and an over-reliance on the Ethiopian Royal Chronicles has led historians to view reports of “famine” during the early zemene mesafint as indicative of severe environmental stress. A more critical reading of the Chronicles, by contrast, suggests that integrating its reports of warfare with the climatological record presents a more accurate chronology of drought severity and possible occurrences of famine.
To tag ornot to tag: comparative performance of tagging and photo-identification in a long-term mark-recapture of Juvenile Green Turtles (Chelonia mydas)
Authors: Buteler Candela , Bardier Cecilia , Cabrera Mario Roberto , Gonzalez Yaco , Vélez-Rubio Gabriela Manuela 
Published: December 2022

Abstract
Capture-mark-recapture (CMR) methods are widely used to estimate population parameters and to collect data on animal demography, migration, and life history. Sea turtle research programs generally use artificial tags, an invasive method. Photo-identification (PID) methods have become an important tool for animal identification. Herein, we assessed the effectiveness of a PID method for marking green turtles (Chelonia mydas) compared to traditional methods (artificial tags). As a part of a long-term CMR study, green turtles have been tagged and photographed since 2001. We analyzed 1917 captures with left and right side photographs of tagged turtles using Wild-ID software, these results were compared with tag-recapture data to assess error rates (false positives and negatives), and different effectiveness metrics. A combination of PID and tags (a match from either method was considered a recapture) was the most error-free and efficient criterion for identification of recaptures; however, it was the most time consuming and invasive criterion as well. We also assessed the effect of image quality indicators on the error rates of PID. We found that turtle cleanliness increases the similarity of images (indirectly related to false negatives), but we found no effect of sharpness, angle, light condition, or width and height in pixels of images on error rates. We could conclude that if image quality is improved, tags could be substituted by PID. However, we strongly recommend researchers to consider local situations (occurrence of by-catch or stranded dead turtles, for which tags are still necessary) before deciding to apply only PID.
The Future Is the Termination Shock: On the Antinomies and Psychopathologies of Geoengineering. Part One
Authors: Malm Andreas 
Published: December 2022

Abstract
As capitalist society remains incapable of addressing climate breakdown, one measure is waiting in the wings: solar geoengineering. No other technology can cut global temperatures immediately. It would alleviate the symptoms of the crisis, not its causes. But might it be combined with radical emissions cuts? This essay, the first instalment of two, scrutinises the rationalist-optimist case for geoengineering: the idea that soot planes in the sky can shield the Earth from the worst heat while society rids itself of fossil fuels. A more likely outcome is that they encourage business-as-usual to continue, while negative side-effects from geoengineering itself pile up. The logic of the enterprise points in the direction of a catastrophic termination shock. A subsequent, second instalment will subject geoengineering to a materialist psychoanalysis and argue that it represents a fantasy of repression, setting itself up for a dreadful return of the repressed.
Pondering the Legacy of Geo Widengren: Isolated Genius, or Uncritical Supporter of a Band of Brothers?
Authors: Larsson Göran 
Published: December 2022

Abstract
This article is both an introduction to a collection of papers that critically discuss and evaluate the volume The Legacy, Life and Work of Geo Widengren and the Study of the History of Religions after World War II, which I edited and published with Brill in 2021, as well as an opportunity for me to think with and about the Swedish historian of religions, Geo Widengren (1907–1996). Widengren was the holder of the chair in the History of Religions and Psychology of Religions at Uppsala University between 1940 and 1973.
The Case for Studying Non-Muslim Islams
Authors: Petersen Jesper , Ackfeldt Anders 
Published: December 2022

Abstract
In this article we define a new concept that has not previously been theorized: non-Muslim Islam. We argue that theories and methodologies within Islamic studies produce a hierarchy between Muslim and non-Muslim productions of Islam, prioritizing the first. However, this article highlights that Islam may be produced for other purposes than belief in a deity; Islam may for example be important in producing non-Muslim identity, politics, aesthetics, narratives, etc. We therefore argue the case for studying non-Muslim Islam, because: 1) Non-Muslim Islams play an important role in Euro-American societies and are therefore interesting in and of themselves; 2) Non-Muslim Islams have a significant impact on Muslim Islams, and thus, we will not understand Muslim Islams without a clear understanding of non-Muslim Islams; 3) It is a way of insisting on an etic research epistemology. The article ends with a discussion of ethical and strategic benefits of adopting this approach.