bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fetal Growth Trajectories and Measures of Insulin Resistance in Young Adults
Authors: Yadav Ashish , Beilin Lawrence J , Huang Rae-Chi , Newnham John P , White Scott W , Mori Trevor A 
Published: May 2023

Abstract

Context
Events during gestation greatly influence the risk of cardiometabolic diseases including diabetes in offspring during later life.

Objective
This study aimed to investigate relationships between serial ultrasound-derived fetal growth trajectories and markers of insulin resistance in young adults in the Raine Study, an Australian pregnancy cohort.

Methods
Linear mixed modeling examined the relationship between fetal growth trajectory groups, constructed using serial ultrasound-based abdominal circumference (AC), femur length (FL), and head circumference (HC) from 1333 mother-fetal pairs, and offspring Homeostatic Model Assessment of Insulin Resistance (HOMA-IR), as a marker of diabetes risk, at 20 (n = 414), 22 (n = 385), and 27 (n = 431) years. Analyses were adjusted for age, sex, ethnicity, socioeconomic status, adult lifestyle factors, and maternal factors during pregnancy.

Results
The study identified 7 AC, 5 FL, and 5 HC growth trajectory groups. Compared to the average-stable (reference) group, a low-falling AC growth trajectory (26%; P = .005) and 2 low HC growth trajectories (20%; P = .006% and 8%; P = .021) were associated with higher adult HOMA-IR. Trajectories representing a high-stable FL and a rising HC were associated with 12% (P = .002) and 9% (P = .021) lower adult HOMA-IR, respectively, compared to the reference group.

Conclusion
Restricted fetal HC and AC from early pregnancy are associated with higher relative insulin resistance in the offspring during adulthood. These data strengthen our understanding of the importance of the intrauterine environment and its effect on the risk of predisposition to adult diabetes and related metabolic disorders.
Birth Weight, Cardiometabolic Factors, and Coronary Heart Disease: A Mendelian Randomization Study
Authors: Su Shuyao , Fan Jingwen , Yang Yongli , Yang Chaojun , Jia Xiaocan 
Published: May 2023

AbstractContextObservational studies have shown associations of birth weight (BW) with coronary heart disease (CHD), but results are inconsistent and do not distinguish the fetal or maternal effect of BW.ObjectiveThis study aims to explore the causal association between BW and CHD, analyze the fetal and maternal contribution, and quantify mediating effects of cardiometabolic factors.MethodsGenetic variants from genome-wide association study summary-level data of own BW (N = 298 142), offspring BW (N = 210 267 mothers), and 16 cardiometabolic (anthropometric, glycemic, lipidemic, and blood pressure) factors were extracted as instrumental variables. We used two-sample Mendelian randomization study (MR) to estimate the causal effect of BW on CHD (60 801 cases and 123 504 controls from mixed ancestry) and explore the fetal and maternal contributions. Mediation analyses were conducted to analyze the potential mediating effects of 16 cardiometabolic factors using two-step MR.ResultsInverse variance weighted analysis showed that lower BW raised the CHD risk (β −.30; 95% CI: −0.40, −0.20) and consistent results were observed in fetal-specific/maternal-specific BW. We identified 5 mediators in the causal pathway from BW to CHD, including body mass index–adjusted hip circumference, triglycerides, fasting insulin, diastolic blood pressure, and systolic blood pressure (SBP), with mediated proportion ranging from 7.44% for triglycerides to 27.75% for SBP. Causality between fetal-specific and maternal-specific BW and CHD was mediated by glycemic factors and SBP, respectively.ConclusionOur findings supported that lower BW increased CHD risk and revealed that fetal-specific and maternal-specific BW may both contribute to this effect. The causality between BW and CHD was mediated by several cardiometabolic factors.
Hypothalamic PVN CRH Neurons Signal Through PVN GABA Neurons to Suppress GnRH Pulse Generator Frequency in Female Mice
Authors: McIntyre Caitlin , Li Xiao Feng , Ivanova Deyana , Wang Jun , O’Byrne Kevin T 
Published: May 2023

AbstractCorticotropin-releasing hormone (CRH) neurons in the paraventricular nucleus of the hypothalamus (PVN) are central to the stress response. Chemogenetic activation of PVN CRH neurons decreases LH pulse frequency but the mechanism is unknown. In the present study, optogenetic stimulation of PVN CRH neurons suppressed LH pulse frequency in estradiol-replaced ovariectomized CRH-cre mice, and this effect was augmented or attenuated by intra-PVN GABAA or GABAB receptor antagonism, respectively. PVN CRH neurons signal to local GABA neurons, which may provide a possible indirect mechanism by which PVN CRH neurons suppress LH pulse frequency. Optogenetic stimulation of potential PVN GABAergic projection terminals in the hypothalamic arcuate nucleus in ovariectomized estradiol-replaced Vgat-cre-tdTomato mice via an optic fiber implanted in the arcuate nucleus suppressed LH pulse frequency. To further determine whether PVN CRH neurons signal through PVN GABA neurons to suppress LH pulsatility, we combined recombinase mice with intersectional vectors to selectively target these neurons. CRH-cre::Vgat-FlpO mice expressing the stimulatory opsin ChRmine in non-GABAergic CRH neurons alone or in combination with the inhibitory opsin NpHR3.3 in non-CRH-expressing GABA neurons in the PVN were used. Optogenetic stimulation of non-GABAergic CRH neurons suppressed pulsatile LH secretion; however, LH pulse frequency was not affected when CRH neurons were stimulated and PVN GABA neurons were simultaneously inhibited. Together, these studies demonstrate that suppression of LH pulse frequency in response to PVN CRH neuronal activation is mediated by GABAergic signalling intrinsic to the PVN and may incorporate PVN GABAergic projection to the hypothalamic GnRH pulse generator.
Exploring the Potential of Lactoferrin in Neonatology and Obstetrics - Promising Advancements for Maternal and Infant Health
Authors: Bialic Kinga , Bialic Artur , Bakalarczyk Rafał , Majewski Paweł , Bednarz Lucjan , Szala-Czerwonka Karolina , Woś Natalia , Rejmer Adrian , Rojek Katarzyna , Wijas Karolina 
Published: May 2023

Introduction and purpose:
Lactoferrin (Lf), a glycoprotein found in body fluids, plays a key role in many of the biological mechanisms that occur in the human body. Over the years, more and more studies have contributed to the expansion of the clinical applications of lactoferrin. In this article, we want to focus on using lactoferrin in Neonatology and Obstetrics. The applications of lactoferrin in obstetrics continue to expand, some of which include the prevention of preterm delivery (PTD) and anaemia in pregnant women. Lf also helps to reduce the incidence of necrotizing enterocolitis and sepsis in newborns by mobilising the immune system and participating in the defence against pathogens and has been under investigation as a potential therapeutic agent for genital infections. The aim of this review is to summarise the current state of knowledge, regarding lactoferrin's broad spectrum of action and to highlight its potential therapeutic applications in these contexts.

State of knowledge:
This article aims to review the current knowledge on the properties of the lactoferrin and its applications in medicine, especially neonatology and obstetrics. Studies available in the PubMed and Google Scholar databases were included in the analysis.

Conclusion:
While lactoferrin shows promise in improving neonatal and maternal health, additional research is required to fully understand its precise mechanisms of action and optimise its use as a therapeutic agent. There is also a need for further studies to assess the safety and efficacy of lactoferrin in a variety of patient populations. Despite the challenges, lactoferrin continues to be an intriguing subject of scientific research, with potential therapeutic benefits in various medical fields.
AUDIT KESELAMATAN JALAN SEBAGAI DASAR IMPLEMENTASI PERENCANAAN KARAKTERISTIK JALAN
Authors: Suwarto Fardzanela , Nugroho Anjang 
Published: May 2023

Peningkatan manajemen keselamatan infrastruktur jalan merupakan komponen kunci untuk peningkatan keselamatan jalan. Untuk meningkatkan keselamatan jalan, selama tahap operasi dan pemeliharaan, otoritas jalan harus menemukan dan memperbaiki masalah keselamatan yang menjadi penyebab kecelakaan jalan, untuk mencegah kembali terjadinya kecelakaan lalu lintas. Sehingga audit keselamatan jalan sangat dibutuhkan, sebagai suatu sistem yang melakukan kontrol kualitas (keselamatan) jalan. Penelitian ini bertujuan untuk melakukan kajian terhadap audit keselamatan jalan yang telah dilakukan pada berbagai lokasi dan melakukan penyimpulan terhadap rekomendasi audit keselamatan jalan dalam hal geometrik dan karakteristik jalan untuk dapat memberikan masukan pada tahapan perencanaan jalan baru di kemudian hari. Hasil dari studi ini adalah pada segmen jalan lurus perencanaan rambu peringatan dan batas kecepatan sangat diperlukan untuk menambah informasi kepada pengemudi. Terkait bagian tikungan dan tanjakan jalan, konsistensi dalam perencanaan radius tikungan mutlak diperlukan. Selain itu khusus untuk daerah tanjakan, pada tikungan perlu dilengkapi marka garis lurus dan rambu batas kecepatan serta rambu dilarang menyiap untuk mengurangi kemungkinan terjadinya kecelakaan lalu lintas.
Tropem Wajdy. Polskie gry cyfrowe o II wojnie światowej między centrum a peryferiami
Authors: Jankowski Filip 
Published: May 2023

Celem artykułu jest syntetyczne ujęcie zjawiska gier cyfrowych II wojnie światowej powstałych w ubiegłym dziesięcioleciu na terenie Polski. Jakkolwiek tematyka ta pojawiała się w polskich grach cyfrowych już wcześniej, dopiero w drugiej dekadzie XXI wieku została przedstawiona bardziej jako traumatyczne doświadczenie aniżeli awanturnicza przygoda. Za przykłady służą trzy gry z lat 2011–2021: Popiół i diament, Warsaw, My Me-mory of Us. Badanie wykazuje, iż wspomniane tytuły odtwarzają narodową martyrologię w manierze filmów Andrzeja Wajdy.
Eyewitness Account of the Nazi Occupation in the South of Ukraine: Diary of a Kherson Resident
Authors: Kaparulin Yurii 
Published: May 2023

Abstract
On March 31, 1944, Captain of Justice G.V. Shliamar, an investigator of the Military Prosecutor’s Office (a member of the Extraordinary State Commission), examined a diary with entries about the beginning of the Nazi occupation of Kherson, which was sent to the military prosecutor’s office and eventually ended up in the archives of the commission in Moscow. The introductory article to the diary describes the historical context and the time of its creation. The source contains a description of events from July 5 to September 15, 1941, which allows us to trace the situation in Kherson and Southern Ukraine during the first months of the German–Soviet war. In particular, the author of the diary recorded the creation of a Jewish ghetto in Kherson, shortly before its liquidation and the organization of mass murder of the city’s Jewish population. Preparation of the diary for publication began in 2021, 80 years after the occupation of Kherson by German troops. On March 2, 2022, during the full-scale invasion of Ukraine by the Russian Federation, Kherson was occupied by Russian troops. This caused historical parallels, in particular through the instrumentalization of the history of the Second World War during the Russian aggression.
Improved design of advanced controller for a step up converter used in photovoltaic system
Authors: Ben Si Ali Nadia , Benalia Nadia , Zerzouri Nora 
Published: May 2023

Abstract
The expanding need for electricity has stimulated research and development of novel supply sources for energy production, conversion, and storage. Many studies are being done to increase the effectiveness of conversion systems as renewable energy is integrated into power networks on a larger scale. The global challenge is to minimize manufacturing costs and increase the use of sustainable resources. In this sense, photovoltaics is viewed as a particularly promising source due to the low cost of implementation and the wide range of applications it could be used for. This research focuses on the analysis, modeling, and simulation of a smart controller for a step-up converter that uses an artificial neural network (ANN) as a maximum power point tracking (MPPT) technique to provide maximum power. The proposed ANN-based algorithm is performed in Matlab/Simulink software, and its effectiveness has been demonstrated under varying climatic conditions.
Biogas production from canteen waste
Authors: Karne Hemlata , Raut Hrutuj , Baviskar Roshan , Rokde Saket , Ravnang Neha , Rathod Darshan 
Published: May 2023

Abstract
Day by day as the population increases, food waste keeps on growing. This waste needs to be managed in order to reduce the number of landfills and to use food waste efficiently. Among the various processes available, Anaerobic Digestion (AD) of food waste is one of the alternatives for processing food waste. The two biggest obstacles to anaerobic digestion of food waste are high biodegradability and high C/N ratio. The C/N ratio determines the ratio between substrate and nutrients; the latter is essential for microbial synthesis and for providing alkalinity through ammonia metabolism. Biogas, a product of the anaerobic digestion process, is a clean and renewable form of energy that can replace conventional energy sources that cause ecological-environmental problems and at the same time are depleted more quickly. The aim of this work was to increase the nitrogen content to enhance the production of biogas from canteen waste. During the process, two digesters of the same capacity were operated. Anaerobic digestion of canteen waste along with addition of ammonium chloride was carried out in Digester 1 while AD of only canteen waste was carried out in Digester 2. The amount of biogas produced in Digester 1 was in the range of 0.04 m3/kg–0.075 m3/kg, while in Digester 2 the volume range was 0.02 m3/kg–0.04 m3/kg. The average biogas produced in digester 1 consisting of canteen waste and nitrogen source was 0.053 m3/kg while biogas production in digester 2 with only canteen waste was 0.030 m3/kg. So, biogas produced by addition of nitrogen source was 77 % higher than that of only canteen waste. From this study we obtained a higher amount of biogas by addition of ammonium chloride as an external nitrogen source. Nitrogen demand of methanogens was fulfilled by additional supply of nitrogen resulting in increased quantity of biogas. Therefore, in anaerobic digestion addition of ammonium chloride was beneficial for food waste digestion. Hence, nitrogen content in canteen waste turned out to be the main parameter affecting anaerobic digestion of canteen waste which is justified in this research.
High mobility group box 1 in women with unexplained recurrent pregnancy loss
Authors: Ticconi Carlo , Mardente Stefania , Mari Emanuela , Barreca Federica , Montanaro Manuela , Mauriello Alessandro , Rizzo Giuseppe , Zicari Alessandra 
Published: May 2023

Abstract

Objectives
To investigate whether high mobility group box 1 (HMGB1) is involved in unexplained recurrent pregnancy loss (uRPL).

Methods
Plasma levels of HMGB1 were measured by ELISA in non-pregnant women with (n=44) and without (n=53 controls) uRPL. Their platelets and plasma-derived microvesicles (MVs) were also assayed for HMGB1. Endometrial biopsies were taken in selected uRPL (n=5) and control women (n=5) and the tissue expression of HMGB1 was determined by western blot and immunohistochemistry (IHC).

Results
plasma levels of HMGB1 were significantly higher in women with uRPL than in control women. HMGB1 content in platelets and MVs obtained from women with uRPL was significantly higher than that obtained from control women. HMGB1 expression in endometrium was higher in tissues obtained from women with uRPL than in tissues obtained from control women. IHC analysis revealed that HMGB1 is expressed in endometrium with different patterns between uRPL and control women.

Conclusions
HMGB1 could be involved in uRPL.
Preservice teachers’ reflections on teacher self-identities through a multicultural children’s literature project
Authors: Iwai Yuko 
Published: May 2023

Abstract
This study examined how 44 preservice teachers reflected on their teacher self-identities through exploring multicultural children’s books, which are published in different time periods, with a focus of analyzing characterization of main characters. The researcher collected data, including a multicultural book project, pre- and post-surveys on multicultural children’s literature and teacher identities, and a reflection paper. Data analysis consisted of looking for and coding emergent themes. The findings of the study showed that preservice teachers analyzed multicultural books from authentic perspectives, focused on how the authors used appropriate language, and examined trends in cultural details and illustrations published in different time periods. They analyzed characteristics of main characters by parsing the facts, by examining the context of the story, and by examining the personalities of main characters. They also refined their teacher identities and strengthened their commitment to become culturally responsive teachers by reflecting on the importance of equity, diversity, and inclusion and embedding high-quality multicultural children’s books into the curriculum. Implications and recommendations are also shared.
A brief synopsis of the psychosocial educational practices in the Arab higher education institutions: a first person’s viewpoint
Authors: Al-Hilawani Yasser A. 
Published: May 2023

Abstract
This is a reflection brief on the psychosocial educational practices in higher education institutions in several Middle East Arab countries. These practices have influenced and led to the formation of current mentalities (i.e., the way of thinking about the prospect and outlook for the future) and realities in the region. The points recounted in this brief could be used as educational learning outcomes for higher education and formal schooling reforms. In the same way that failure is a result of within, success must also come from within.
Control strategy for plug-in electric vehicles with a combination of battery and supercapacitors
Authors: Reddy Mallu Rama Prasad , Sarma Saraswathula Subramanya , Murthy Vangala Naga Siva Rama , Kowstubha Challagulla Kesava Tripureswari Sita Raghava 
Published: May 2023

Abstract
Research proposes an optimal power distribution approach for application of electric vehicle (EV) with use of hybrid energy storage system (HESS). HESS protection structure includes dual isolated-based soft-switching symmetrical coupling with half-bridge bidirectional converters to the system of battery and supercapacitors (SCs). The bidirectional converter properly controls the charging process of the battery and SC as well. Besides, spiral wound SCs of mesoporous electrode material have been used in EVs. In the drive cycle of EVs, the operation of SC relates to the functionality of the allocated scheme under “peak load transfer” at 2i
sc ∼ 3i
bat current profile carried out. New energy allocation strategies under SOC control enable SC charging and discharging at peak currents of around 4i
bat. The comparison of the mode of the battery system showed that the performance acceleration built under EVs has been improvised at a certain rate of 50% with a loss of energy minimised to 69%. As a result, the technique adapts different load curves, thus enhancing the utilisation of energy with reduced aging of the battery. The simulation results show that the proposed scheme meets the power demand of a typical driving cycle, for testing vehicle performance, and various energy management system have been assessed based on hydrogen consumption, overall efficiency, state of charge of SCs and batteries, stress on hybrid sources, and DC bus stability. The proposed strategy reduces hydrogen consumption by 8.7% compared to other strategies.
Vendo (?) as expressões simbólicas e contextos de uma narrativa outra: da Queermuseu às ruínas do museu
Authors: Monsell Alice J. 
Published: May 2023

Neste artigo tento elucidar algumas das questões que emergiram da experiência de visitar a exposição coletiva Queermuseu em Porto Alegre no final de 2017, três dias antes de seu fechamento com quase um mês de antecedência, situação que solicita a reflexão sobre a arte contemporânea, revendo questões já abordadas por Arthur Danto e Douglas Crimp, tais como, o display museológico; as implicações para um público de uma arte reproduzida na internet, a presença do observador e da obra; e o desconhecimento sobre os procedimentos artísticas da arte contemporânea, como a apropriação, a reutilização e a pós-produção de imagens captadas pelo artista. Também discutirei outras exposições que abordaram temáticas queer: Queer British Art, Londres e Hide/Seek: Difference and Desire in American Portraiture, que também passou pela censura nos EUA em 2010. Seeing (or not?) other narratives and contexts of symbolic expression: from Queermuseu to the ruins of the museumAbstract: In this article I try to elucidate some of the issues that emerged from the experience of visiting the Queermuseu exhibition in Porto Alegre at the end of 2017, three days before its closure almost a month in advance, a situation that calls for reflection on contemporary art, and review issues already addressed by Arthur Danto and Douglas Crimp, such as the museological display; the issues of the public and it’s reception of art reproduced on the internet, the presence of the observer and the work of art, the lack of knowledge about the procedures of contemporary art, such as appropriation, reuse and post-production of images captured by the artist. We also discuss exhibitions that dealt with similar themes: Queer British Art, London and Hide / Seek: Difference and Desire in American Portraiture which also was censored in the USA in 2010.
Intervenções estéticas, interpelações políticas: breves incursões na arte urbana latino-americana
Authors: Moreira Maria Elisa Rodrigues 
Published: May 2023

Parte das produções artísticas contemporâneas se constitui de projetos de intervenção urbana com forte caráter social, que, simultaneamente, transformam esteticamente o espaço citadino e interpelam politicamente aqueles que por ele transitam, remetendo ao que Jacques Rancière denomina “regime estético das artes”. Este artigo propõe uma breve incursão por algumas dessas produções, as quais possibilitam refletir sobre as aproximações entre cultura, arte e política no espaço latino-americano. Aesthetic interventions, political interpellations: brief incursions into Latin American urban art Abstract: Part of contemporary artistic production consists of urban intervention projects with a strong social character, which simultaneously transforms city space aesthetically and politically interrupts those who pass through it, referring to what Jacques Rancière calls the "aesthetic regime of art". This article proposes a brief descent into some of this production, allowing us to reflect on the connections between culture, art and politics in Latin American space.
UN VIAJE AL SUR
Authors: Villot Gabriel 
Published: May 2023

Resumen: Serie de trabajos del artista argentino Gabriel Villot realizados con técnica de lápiz, tinta y acuarela sobre tela con dimensiones variadas. Palabras-claves: Arte Contemporánea; Acuarela, Arte Argentina. UMA VIAGEM AO SUL Resumo: Série de trabalhos do artista argentino Gabriel Villot realizados com técnica de lápis, tinta e aquarela sobre tela com dimensões que variadas. Palavras-chave: Arte Contemporânea; Aquarela, Arte Argentina.
Narrativas de uma destruição: Raquel Andrade Ferreira
Authors: Ferreira Raquel Andrade 
Published: May 2023

Este ensaio visual apresenta quadros selecionados do vídeo de Raquel Ferreira, Narrativas de uma Destruição-Parte V, de 2012 Narratives of a destruction: Raquel Andrade Ferreira Abstract: This visual essay presents selected frames from Raquel Ferreira’s video, Narratives of a Destruction-Part V produced in 2012.