bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of gestational metabolic syndrome with the Chinese Healthy Eating Index in mid-pregnancy: a cross-sectional study
Authors: Liu Yu-hong , Lu Ling-peng , Wu Hui , Yi Min-hui , Liu Bing-gang , Xu Yan , Wu Qin 
Published: March 2023

Abstract
Background We established a mid-pregnancy version of CHEI-2022 based on the Chinese Healthy Eating Index (CHEI), with reference to the amount of food recommended by Dietary Guidelines for Chinese Residents (DGC-2022) for mid-pregnancy. To explore the relationship between gestational metabolic syndrome (GMS) and the CHEI in mid-pregnancy and to identify potentially beneficial or high-risk dietary habits.
Methods Based on the inclusion and exclusion criteria, the data of 2,411 mid-pregnancy was collected by interview. Total CHEI score and its component scoreswere calculated based on the food frequency questionnaire. Physical examination and blood biochemical tests were used to diagnose GMS. The logistic regression model was used to analyze the relationship between GMS or relative indexes and the total CHEI score or its component scores.
Results The study showed the overall prevalence of GMS was 21.65%(522/2,411). Mid-pregnancy with GMS had a higher BMI, FBG, 1hPBG, 2hPBG, TC, TG, HDL, SBP, degree of education, and daily activity than those without GMS (p < 0.001).After adjusting for potential confounders, it showed that the higher total CHEI scores(≥ 80) ,the lower risk of GMSor relative indexes (P<0.05). The GMS or relative indexes risks were reduced by increasing the dietary content of potatoes, whole grains, beans, dark green vegetables, and fruits in the CHEI (P < 0.05).
Conclusion The quality of healthy diet (total CHEI score≥ 80) and increased intake of specificdietary components (potatoes, beans, dark green vegetables ,fruits) were effective in reducing the risk of GMS or relative indexes in mid-pregnancy.
Limitations in physical function and depressive symptoms among Chinese older men and women: the moderating effects of family ties and friendship ties
Authors: Tang Dan , Tang Dan , Hu Qing , Zhang Kun 
Published: March 2023

Abstract
Background
Most studies exploring the moderating effects of social networks between limitations in physical function and depressive symptoms fail to distinguish the effect of different circle of social networks. The aim of this study was to examine the association among limitations in physical function, social networks and depressive symptoms, and explore the moderating effects of family ties and friendship ties among Chinese older men and women.
Methods
Data on 7770 participants (mean age = 69.12, SD = 7.50; men, 54.0%) from the baseline China Longitudinal Aging Social Survey were analysed. Linear regressions were used to evaluate the association among limitations in physical function, social networks, and depressive symptoms. The moderating effects of family ties and friendship ties and gender differences were also examined.
Results
Limitations in physical function were significantly associated with depressive symptoms (B = 0.275). More limitations in physical function were associated with poorer family ties (B=-0.042) and friendship ties (B=-0.195); the coefficient of limitations in physical function on friendship ties was significantly larger than that on family ties (χ2 = 38.41). Both family (B=-0.177) and friendship ties (B=-0.061) were associated with lesser depressive symptoms. The interaction between limitations in physical function and family ties was significantly negative in the total sample (B=-0.011), whereas the interaction between limitations in physical function and friendship ties was significantly positive among older women (B = 0.009). Female older adults with more limitations in physical function reported weaker family (B=-0.052, p < 0.01) and friendship ties (B=-0.210, p < 0.001). Male older adults with more limitations in physical function reported weaker friendship ties (B=-0.184, p < 0.001). However, the limitations in physical function of male older adults had a marginally significant effect on their family ties (B=-0.032, p < 0.1).
Conclusions
These findings highlight the different roles of family and friendship ties for older adults with various physical function status. Older adults, especially older women, who are healthy and can care for themselves should be encouraged to expand friendship ties to maintain their mental health. Moreover, the family and communities should provide enough support for older adults with limitations in physical function to reduce their depressive symptoms.
Developing a Global Medicine Student Pre- and Post-Travel Curriculum
Authors: Mehta Natasha , Fernandes Caroline , Llerena Christopher , Weine Stevan , Bosland Maarten C. 
Published: March 2023

Abstract
Background
The popularity of short-term global health experiences amongst US medical students has been increasing. However, it remains a challenge for medical schools to comprehensively prepare students to work in an international environment and to contribute in ethically responsible and meaningful ways. Students of the Global Medicine program (GMED) of the UIC College of Medicine Center for Global Health set out to develop a pre-and-post travel curriculum that addresses some of these challenges.
Methods
The students surveyed the literature and published global health curricula and identified aspects of pre-and-post travel training that were found to be under-addressed in the. They then developed a curriculum in conjunction with GMED faculty that incorporated these identified aspects of pre-and-post travel training.
Results
Five aspects of pre-and-post travel training were identified as being both under-addressed in the literature and in student’s personal experiences while traveling. These domains include: (1) examining power relations associated with neo-colonization between and within countries; (2) training for bi-directional learning; (3) examining motivations and goals for participating in global health; (4) addressing personal resiliency and psychosocial wellbeing related to students’ travel, and; (5) reflecting on the challenging aspects of the fieldwork experience.
Conclusions
The student-driven curriculum is being integrated into the GMED program through structured didactic sessions, one-on-one mentor meetings and small group discussions. Once students have traveled, an evaluation of the curriculum will be conducted together with the foreign partners they visited.
Proteomic analysis of 92 circulating proteins and their effects in cardiometabolic diseases
Authors: Carland Corinne , Png Grace , Malarstig Anders , Kho Pik Fang , Gustafsson Stefan , Michaelsson Karl , Lind Lars , Tsafantakis Emmanouil , Karaleftheri Maria , Dedoussis George , Ramisch Anna , Macdonald-Dunlop Erin , Klaric Lucija , Joshi Peter K. , Chen Yan , Björck Hanna M. , Eriksson Per , Carrasco-Zanini Julia , Wheeler Eleanor , Suhre Karsten , Gilly Arthur , Zeggini Eleftheria , Viñuela Ana , Dermitzakis Emmanouil T. , Wilson James F. , Langenberg Claudia , Thareja Gaurav , Halama Anna , Schmidt Frank , Consortium SCALLOP , Zanetti Daniela , Assimes Themistocles 
Published: March 2023

Abstract
Background: Human plasma contains a wide variety of circulating proteins. These proteins can be important clinical biomarkers in disease and also possible drug targets. Large scale genomics studies of circulating proteins can identify genetic variants that lead to relative protein abundance.
Methods: We conducted a meta-analysis on genome-wide association studies of autosomal chromosomes in 22,997 individuals of primarily European ancestry across 12 cohorts to identify protein quantitative trait loci (pQTL) for 92 cardiometabolic associated plasma proteins.
Results: We identified 503 (337 cis and 166 trans) conditionally independent pQTLs, including several novel variants not reported in the literature. We conducted a sex-stratified analysis and found that 118 (23.5%) of pQTLs demonstrated heterogeneity between sexes. The direction of effect was preserved but there were differences in effect size and significance. Additionally, we annotate trans-pQTLs with nearest genes and report plausible biological relationships. Using Mendelian randomization, we identified causal associations for 18 proteins across 19 phenotypes, of which 10 have additional genetic colocalization evidence. We highlight proteins associated with a constellation of cardiometabolic traits including angiopoietin-related protein 7 (ANGPTL7) and Semaphorin 3F (SEMA3F).
Conclusion: Through large-scale analysis of protein quantitative trait loci, we provide a comprehensive overview of common variants associated with plasma proteins. We highlight possible biological relationships which may serve as a basis for further investigation into possible causal roles in cardiometabolic diseases.
Impact of HPV-16 lineages infection on response to radio-chemotherapy in cervical cancer
Authors: de Figueiredo Fábio Vidal , Santos Gerusinete Rodrigues Bastos dos , Vidal Flávia Castello Branco , Silva Marcos Antonio Custódio Neto da , Silva Rodrigo Lopes da , Batista Zulmira da Silva , de Andrade Marcelo Souza , Barbosa Maria do Carmo Lacerda , Maniçoba Anna Cyntia Brandão Nascimento , Silva Mayara Cristina Pinto da , Nascimento Maria do Desterro Soares Brandão 
Published: March 2023

Abstract
Aim
Estimate the frequency of Human papilloma virus (HPV) 16 lineages in specimens of cervical cancer, relate the pathological factors in those variants and assess the response to treatment with radical chemoradiotherapy.
Methods
Samples of cervical cancer were collected from women referred to reference cancer hospital to test the presence of Human papilloma virus types DNA. The standard protocol of the service consisted of cisplatin based chemotherapy 40 mg/m² plus conventional pelvic irradiation in the dosis of 45-50.4 Gy and high dose rate brachytherapy of 28–30 Gy to Point A. The response to chemotherapy was avaliated after three months in those patients with HPV − 16 lineage.
Results
HPV DNA was detected in out 104 (88.1%) of the 118 patients. HPV-16 present in 63 patients (53%). Lineages of HPV 16 identified in 57 patients being: 33 (57.8%) lineage A, 2 lineage B (3.5%), 2 lineage C (3.5%) and 20 (35.0%) lineage D. The median age of the patients was 48.4 years (range 25–85 years). Squamous cell carcinoma was detected 48 times (84.2%). Adenocarcinoma were more likely to occur in lineage D, as three of the four cases occurred in this lineage. A total of 11patientes with HPV-16 variant were treated with chemoradiotherapy. After three months, was observed that nine of the eleven patients (81.8%) achieved complete response: five of the lineage A, two of the lineage C and two of the lineage D. The cases of partial response and progression of disease, one each, occurred in the lineage A.
Conclusion
Besides the small number of patients and HPV variants, we notice better response in patients with HPV 16 lineage A. Increasing the sample could be helpful to better associate the impact of HPV variants on cervical cancer treatment.
Do wars abroad affect attitudes at home? Russia’s invasion of Ukraine and European public opinion
Authors: vlandas Tim , Klymak Margaryta 
Published: March 2023

Abstract
What is the effect of wars abroad on the attitudes of people living in countries that are not directly involved? Using representative samples from eight European countries, we explore how the Russian invasion has affected over twenty social and political attitudes. To estimate causal effects, we adopt the ‘Unexpected Event during Survey Design’ which leverages the overlap between the survey fieldwork and the timing of Russia’s invasion. We find that the war increased support for democracy, redistribution, Europe, and immigration, while it reduced authoritarian attitudes. Our findings are the first to show empirically that wars abroad have a causal impact on public opinion even in countries not directly involved in a conflict.
Seasonal sediment dynamics in a constructed and natural tidal marsh in the northern Gulf of Mexico
Authors: Dybiec Jacob , Rinehart Shelby , Cherry Julia 
Published: March 2023

Abstract
Declines in sediment loading, combined with sea-level rise, are a major driver of recent tidal marsh loss. As such, evaluations of sediment dynamics are necessary for assessments of current and future marsh resilience to sea-level rise. While tidal marsh creation is used to offset these losses, few studies have assessed sediment dynamics in these systems; those that have were focused on accumulation at a single time and/or place, without considering the composition of accumulated sediment (i.e., organic vs. inorganic). We compared seasonal sediment dynamics between a natural and nearby 34-year-old constructed tidal marsh in the northern Gulf of Mexico. In July 2021, we set up a series of permanent sampling points along one tidal creek in each marsh and made monthly measurements of sedimentation, surface organic matter accumulation, and surface scour for one year. We found that sedimentation and organic matter accumulation were lower in the constructed marsh, while surface scour did not differ. Additionally, we found that the relationship between distance from the mouth of each tidal creek and sedimentation differed between marshes (positive in natural, negative in constructed), as did organic matter accumulation (no relationship in natural, positive in constructed). Despite this, we found that both marshes followed similar seasonal trends in sediment accumulation (highest in summer, lowest in winter). Our results suggest that considering local sedimentation rates is critical to insuring that adequate sedimentary dynamics develop in restored and created marshes, underscoring the importance of evaluating spatial and temporal variation in sedimentary dynamics to assess restoration outcomes.
Methamphetamine use increases the risk of cerebral small vessel disease in young patients with acute ischemic stroke
Authors: Zhu Zhu , Vanderschelden Benjamin , Shafie Mohammad , Soun Jennifer E , Chow Daniel , Chang Peter , Stradling Dana , Blackwill Haley , Yu Wengui 
Published: March 2023

Abstract
Methamphetamine use causes spikes in blood pressure. Chronic hypertension is a major risk factor for cerebral small vessel disease (cSVD). The aim of this study is to investigate whether methamphetamine use increases the risk of cSVD. Consecutive patients with acute ischemic stroke at our medical center were screened for methamphetamine use and evidence of cSVD on MRI of the brain. Methamphetamine use was identified by self-reported history and/or positive urine drug screen. Propensity score matching was used to select non-methamphetamine controls. Sensitivity analysis was performed to assess the effect of methamphetamine use on cSVD. Among 1369 eligible patients, 61 (4.5%) were identified to have a history of methamphetamine use and/or positive urine drug screen. Compared with the non-methamphetamine group (n = 1308), the patients with methamphetamine abuse were significantly younger (54.5 ± 6.9 vs. 70 ± 12.4, p < 0.001), male (77% vs. 54%, p < 0.001) and White (78.7% vs. 51%, p < 0.001). Sensitivity analysis showed that methamphetamine use was associated with increased white matter hyperintensities, lacunes, and total burden of cSVD. The association was independent of age, sex, acute hypertension, and stroke severity. Our findings suggest that methamphetamine use increases the risk of cSVD in young patients with acute ischemic stroke.
Depositional characteristics of microbial carbonate reservoir and their effects on favorable reservoir distributions of the IV Member of Sinian Dengying Formation, Gaoshiti-Moxi area, Sichuan Basin, Southwest China
Authors: Wang Yuan , Wang Shaoyong , Yan Haijun , Zhang Yijie , Zhao Zhenyu , Ma Debo 
Published: March 2023

Abstract
Previous scientific research on reservoirs of the Deng IV Member in Gaoshiti-Moxi area, the main production area of Anyue gas field with tens of billions of cubic meters reserves, concerns on karst paleogeomorphology reconstruction, facies distribution on platform margin and their effects on favorable reservoirs. However, the quality of microbial carbonate reservoirs is also closely related with their original depositional environments on the whole platform, which is significant for further petroleum exploration and exploitation of ultra-deep carbonate reservoirs in this area. Therefore, this paper attempts to reveal favorable microbial carbonate reservoir characteristics and sedimentary effects on their distribution and prediction, based dominantly on synthetic analysis of depositional characteristics, including both sequence stratigraphy and facies, such as seismic facies, microfacies and microfacies associations. The results show that favorable reservoirs of the Deng IV Member are classified into three types according to their space types, namely, fracture-cavity reservoir, pore-cavity reservoir and pore. Secondary dissolution pores and cavities are primary reservoir spaces developed mainly in non-skeletal grain dolomites with sparry cements, thrombolites, and stromatolites in microfacies association 1 (MA1), MA2, MA5, and MA7. Physical property of fracture-cavity type of reservoir is better in the upper and lower parasequence sets with a porosity between 1% and 5%, a permeability between 0.01 × 10− 3 µm2 and 1 × 10− 3 µm2; physical property of pore-cavity reservoir is fine throughout all the parasequence sets with a porosity between 2% and 4%, a permeability between 0.01 × 10− 3 µm2 and 1 × 10− 3 µm2; physical property of pore-cavity reservoir is the worst. In vertical, the favorable reservoirs are developed mainly in parasequence set 6 (PSS6) and PSS7 in vertical. On planar, they are distributed in well zone MX9-MX19-MX1 for the fracture-cavity type, MX105-MX110-GS20 for the pore-cavity type and MX17-MX107-MX41-MX102-GS102 for the pore type. What’s more, effects of depositional sequences, seismic facies, microfacies and microfacies associations on reservoir distribution indicate that to some extent, fracture-cavity type of reservoir is constrained by the top boundaries of PSS7, PSS2, parasequence 17 (PS17) and PS14; pore-cavity type of reservoir by the top boundaries of PSS7, PSS4, PS18 and PS12; pore type of reservoir by the top boundaries of PSS7, PSS6, PSS3, PSS2, PS18, PS17, PS14, and PS12. Seismic facies associated with shoals and of mound-flat complex are related with facies distributions of pore cavity and pore reservoirs. MA1, MA3, MA7, MA8 are predominant microfacies associations of favorable reservoirs of the Deng IV Member in Gaoshiti-Moxi area.
Assessment of the Capacity of ChatGPT as a Self-Learning Tool in Medical Pharmacology: A Study Using MCQs
Authors: Choi Woong 
Published: March 2023

Abstract
Background
ChatGPT is a large language model (LLM) developed by OpenAI. Drawing upon a substantial textual corpus, ChatGPT exhibits a remarkable ability to simulate human speech. This investigation attempts to evaluate the potential of ChatGPT as a self-directed learning resource, with specific attention to its efficacy in answering multiple-choice questions (MCQs) and furnishing coherent rationale for its responses.
Methods
The study used 78 MCQs from the Korean Basic Medical Science Comprehensive Assessment (K-BMSCA) for years 2019 to 2021. The test items were translated from Korean to English, and lead-in prompts were engineered to test ChatGPT's ability to generate correct and relevant responses. Each test item produced four questions with different prompts. The questions were submitted to ChatGPT, and the responses were analyzed for correctness, consistency, and relevance.
Results
The study evaluated the efficacy of ChatGPT in responding to a total of 312 questions with an overall accuracy of 76.0% (237/312). The model demonstrated a commendable performance in addressing questions related to recall and interpretation, whereas its performance in solving problems was comparatively poor. ChatGPT offered correct rationales for 77.8% (182/234) of the responses, with errors primarily arising from two sources: faulty information and flawed reasoning. In terms of references, ChatGPT furnished incorrect citations for 69.7% (191/274) of the responses. While the veracity of reference paragraphs could not be ascertained, 80.4% (41/51) were deemed pertinent and accurate with respect to the answer key.
Conclusion
While ChatGPT has potential utilities in answering MCQs and generating the correct associated rationale, it shows poor performance in referencing. The limitations of ChatGPT as a self-learning tool should be explained and emphasized to students for a wise usage of AI technology.
Factors Associated With Anal Incontinence in Elderly Women Practicing Physical Exercises: A Cross-Sectional Study
Authors: Henrique Thaise dos Santos , de Arruda Guilherme Tavares , Santos Maiara Gonçalves dos , Mazo Giovana Zarpellon , Virtuoso Janeisa Franck 
Published: March 2023

Abstract
This study verified the risk factors for Anal incontinence (AI) in elderly women who exercise. Cross-sectional study with elderly women from southern Brazil. Gynecological-obstetric and behavioral information, anthropometric measurements and physical skills were evaluated. The symptoms of AI were assessed using the Colorectal-Anal Distress Inventory (CRADI-8). Variables with p ≤ 0.05 were taken into account for the logistic regression model. One hundred and twenty-nine elderly women (69.41 ± 4.95 years) participated in the study. The variables previous gynecological surgery (OR 2.18, 95% CI, 1.02–4.81), number of pregnancies (OR 1.32, 95% CI, 1.02–1.71) and urinary incontinence (UI) (OR 2.22; 95% CI, 1.01–4.87) were at risk for AI. Previous gynecological surgery, number of pregnancies and UI are risk factors for AI in elderly women who practice physical exercises. Implications for practice: We suggest to develop physical activity and rehabilitation programs aimed at the elderly population.
Optical Trapping of Sub-millimeter Sized Particles and Microorganisms
Authors: Lialys Laurynas , Lialys Justinas , Salandrino Alessandro , Ackley Brian D. , Fardad Shima 
Published: March 2023

Abstract
While Optical Tweezers (OT) are mostly used for confining smaller size particles, the counter-propagating (CP) dual-beam traps have been a versatile method for confining both small and larger size particles including biological specimen. However, CP traps are complex sensitive systems, requiring tedious alignment to achieve perfect symmetry with rather low trapping stiffness values compared to OT. Moreover, due to their relatively weak forces, CP traps are limited in the size of particles they can confine which is about 100µm. In this paper, a new class of counter-propagating optical tweezers with a broken symmetry is discussed and experimentally demonstrated to trap and manipulate larger than 100µm particles inside liquid media. Our technique exploits a single Gaussian beam folding back on itself in an asymmetrical fashion forming a CP trap capable of confining small and significantly larger particles (up to 250µm in diameter) based on optical forces only. Such optical trapping of large-size specimen to the best of our knowledge has not been demonstrated before. The broken symmetry of the trap combined with the retro-reflection of the beam has not only significantly simplified the alignment of the system, but also made it robust to slight misalignments and enhances the trapping stiffness as shown later. Moreover, our proposed trapping method is quite versatile as it allows for trapping and translating of a wide variety of particle sizes and shapes, ranging from one micron up to a few hundred of microns including microorganisms, using very low laser powers and numerical aperture optics. This in turn, permits the integration of a wide range of spectroscopy techniques for imaging and studying the optically trapped specimen. As an example, we will demonstrate how this novel technique enables simultaneous 3D trapping and light-sheet microscopy of C. elegans worms with up to 450µm length.