bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Engineered Nanosugar Enables Rapid and Sustained Glucose‐Responsive Insulin Delivery in Diabetic Mice
Authors: Xu Rong , Bhangu Sukhvir Kaur , Sourris Karly C. , Vanni Domitilla , Sani Marc‐Antoine , Karas John A. , Alt Karen , Niego Be'eri , Ale Anukreity , Besford Quinn A. , Dyett Brendan , Patrick Joshua , Carmichael Irena , Shaw Jonathan E. , Caruso Frank , Cooper Mark E. , Hagemeyer Christoph E. , Cavalieri Francesca 
Published: March 2023

AbstractGlucose‐responsive insulin‐delivery platforms that are sensitive to dynamic glucose concentration fluctuations and provide both rapid and prolonged insulin release have great potential to control hyperglycemia and avoid hypoglycemia diabetes. Here, biodegradable and charge‐switchable phytoglycogen nanoparticles capable of glucose‐stimulated insulin release are engineered. The nanoparticles are “nanosugars” bearing glucose‐sensitive phenylboronic acid groups and amine moieties that allow effective complexation with insulin (≈95% loading capacity) to form nanocomplexes. A single subcutaneous injection of nanocomplexes shows a rapid and efficient response to a glucose challenge in two distinct diabetic mouse models, resulting in optimal blood glucose levels (below 200 mg dL–1) for up to 13 h. The morphology of the nanocomplexes is found to be key to controlling rapid and extended glucose‐regulated insulin delivery in vivo. These studies reveal that the injected nanocomplexes enabled efficient insulin release in the mouse, with optimal bioavailability, pharmacokinetics, and safety profiles. These results highlight a promising strategy for the development of a glucose‐responsive insulin delivery system based on a natural and biodegradable nanosugar.
Tunable Efficient White Emission in Holmium Doped Double Perovskites Cs2KInCl6 via Antimony Sensitization
Authors: Huang Weiguo , Peng Hui , Wei Qilin , Xia Jingjing , He Xuefei , Ke Bao , Tian Ye , Zou BingSuo 
Published: March 2023

AbstractRecently, ns2 metal ions (such as Bi3+ and Sb3+) doped double perovskites have captured intense attention for their efficient emission, however, achieving efficient and tunable white light emission is always an enormous challenge. Herein, Sb3+/Ho3+ co‐doped Cs2KInCl6 double perovskites are proposed, and the photoluminescence results show that there are two emission bands, one broad cyan emission band stems from self‐trapped exciton (STE) in [SbCl6]3‐ octahedron, while another red emission band derives from the f‐f transitions of Ho3+. The emission processes for Sb3+/Ho3+ co‐doped Cs2KInCl6 show that Sb3+ can act as the sensitizer to activate Ho3+ emission, which is due to the energy transfer channel from STE to Ho3+. As the Ho3+ concentration increases, the luminous color of Sb3+/Ho3+ co‐doped Cs2KInCl6 can be modulated from cyan to orange under 315 nm light irradiation, and the white emission can even be obtained with a photoluminescence quantum yield of 90 ± 2% when the energy‐transfer efficiency is 50%. Finally, single compound white‐light emitting diodes and fluorescent anti‐counterfeiting labels based on 0.5%Sb3+/60%Ho3+ co‐doped Cs2KInCl6 are fabricated. This work provides an effective strategy to achieve efficient tunable white emission in lead‐free double perovskites through ns2 metal and lanthanide ion co‐doping.
Site‐Engineering for Controlling Multiple‐Excitation and Emission in Eu2+‐Activated CaSrSiO4 Phosphors in Marine Fisheries
Authors: Liu Shuifu , Wen Dawei , Du Rongkai , Jiang Chunyan , Chen Jun , Li Junhao , Zhou Lei , Molokeev Maxim S. , Wu Mingmei 
Published: March 2023

AbstractArtificial light fishing technology has been used in marine fisheries for thousands of years. The light source with multi‐color adjustable output is expected to become a new generation of fish‐attracting lamps. Herein, a new method of crystal‐site engineering through reducing atmospheres is proposed for the development of Eu2+ doped single‐phase phosphor with multi‐excitation and multi‐emission properties. Following this approach, the distribution ratio of Eu2+ at Ca2+ and Sr2+ sites in CaSrSiO4 (CSO) can be modulated. Importantly, Eu2+ at both lattice sites exhibit non‐interfering optical properties, CSO:Eu2+ phosphor realizes multi‐color output from green to yellow and then to red when Eu2+ occupies the Sr2+ and Ca2+ sites in a relatively balanced ratio. Benefitting from the tunable color range covering the spectral sensitivity regions of most marine fishes, this phosphor may eventually be applied in futuristic innovative fish‐attracting lamps.
Census of potential predators and competitors of sandfish, Holothuria scabra, juveniles during floating hapa ocean nursery culture
Authors: C. Gorospe Jay R , Rescordado Racelle R. , Juinio‐Meñez Marie Antonette , Cruz Margarita dela Torre‐dela , Southgate Paul C. 
Published: March 2023

AbstractPredation and competition are among the most important factors affecting sandfish, Holothuria scabra, growth and survival in ocean‐based production systems. In this study, the potential predators and competitors of sandfish juveniles reared at two sites in the Philippines using the floating hapa ocean nursery system were assessed. A total of 26 species of potential predators and competitors from 16 different families of fishes, molluscs and crustaceans were recorded. These taxa were dominated by the opisthobranch Stylocheilus striatus at Bolinao (north–west Luzon) and the isopod Cymodoce sp. at Maliwaliw (eastern Visayas). Highest number of potential predators and competitors that recruited and/or migrated to the inside of floating hapa nets was recorded on day 23 at Bolinao and day 30 at Maliwaliw, then decreased over the 69‐day duration of the study. Mean length, absolute growth rates (AGRs) and survival of sandfish juveniles reared in floating hapas at the two sites varied during the study. AGRs were highest at 1.17 ± 0.06 mm day−1 at Bolinao, and 1 ± 0.08 mm day−1 at Maliwaliw, by days 23 and 60, respectively. Mean lengths of sandfish juveniles reared at Bolinao and Maliwaliw by the end of the study were 46.7 ± 0.15 and 58.8 ± 2.4 mm, respectively, and survival at both sites was high at 96% by the end of the study. Negative correlations were observed between the number of individual predators and competitors, and survival and growth rates of sandfish juveniles reared at Bolinao and Maliwaliw, respectively. Our results highlight the importance of predator and competitor management measures and appropriate site selection to optimize growth performance and survival of sandfish juveniles reared in ocean‐based culture production systems.
Reproductive justice for Black, Indigenous, Women of Color: Uprooting race and colonialism
Authors: Suarez‐Balcazar Yolanda , Buckingham Sara , Rusch Dana B. , Charvonia Alissa , Young Rebecca Ipiaqruk , Lewis Rhonda K. , Ford‐Paz Rebecca E. , Mehta Tara G. , Perez Carolina Meza 
Published: March 2023

AbstractHistorically, atrocities against Black, Indigenous, and Women of Color's (BIWoC) reproductive rights have been committed and continue to take place in contemporary society. The atrocities against BIWoC have been fueled by White supremacy ideology of the “desirable race” and colonial views toward controlling poverty and population growth, particularly that of “undesirable” races and ethnicities. Grounded in Critical Race Theory, this paper aims to provide a critical analysis of historical and contemporary violations of BIWoC reproductive rights; discuss interventions based on empowerment and advocacy principles designed to promote women's reproductive justice; and discuss implications for future research, action, and policy from the lenses of Critical Race Theory and Community Psychology. This paper contributes to the special issue by critically analyzing historical and contemporary racism and colonialism against BIWoC, discussing implications for future research and practice, and making policy recommendations.
Child well‐being before and after the 2020 COVID‐19 lockdowns in three Australian states
Authors: Allen Jacqueline B. H. , Homel Ross J. , McGee Tara R. , Freiberg Kate J. 
Published: March 2023

AbstractThis paper reports on changes in the social‐emotional well‐being of 6‐ to 12‐year‐old children tested before the COVID‐19 pandemic and during 2020 and 2021. Well‐being was assessed using a video game that empowers children to report their own well‐being, including school attachment, social and emotional well‐being, behavioural conformity and family support. We compared well‐being over time for two groups of children in government schools in Queensland, Western Australia and Tasmania. The treatment group of 580 children were tested in 2019 (Time 1) and a second time in mid‐late 2020 and early 2021 (Time 2). The comparison group of 841 children were tested twice before the pandemic. Results showed that children in the treatment group reported significantly lower family support at Time 2 than those in the comparison group. This reduction in perceived family support was stronger for girls. In addition, children in the treatment group who reported lower levels of family support at Time 1 reported a steeper decline in family support by Time 2. Finally, boys in the treatment group reported significantly better behavioural conformity and emotional well‐being relative to girls over time. Results highlight the varied impacts of the pandemic lockdowns and the need to provide continued support to vulnerable families.
A Spectroscopic Study on Nitrogen Electrooxidation to Nitrate
Authors: Li Tieliang , Han Shuhe , Wang Yuting , Zhou Jin , Zhang Bin , Yu Yifu 
Published: March 2023

AbstractAs a potential substitute technique for conventional nitrate production, electrocatalytic nitrogen oxidation reaction (NOR) is gaining more and more attention. But, the pathway of this reaction is still unknown owing to the lack of understanding on key reaction intermediates. Herein, electrochemical in situ attenuated total reflection surface‐enhanced infrared absorption spectroscopy (ATR‐SEIRAS) and isotope‐labeled online differential electrochemical mass spectrometry (DEMS) are employed to study the NOR mechanism over a Rh catalyst. Based on the detected asymmetric NO2− bending, NO3− vibration, N=O stretching, and N−N stretching as well as isotope‐labeled mass signals of N2O and NO, it can be deduced that the NOR undergoes an associative mechanism (distal approach) and the strong N≡N bond in N2 prefers to break concurrently with the hydroxyl addition in distal N.
Importance of Adatom on Pure Iron Catalyst Towards Electrocatalytic N2 Reduction Reaction
Authors: Das Arunendu , Das Sandeep , Pathak Biswarup 
Published: March 2023

AbstractThe Haber‐Bosch process using Fe‐based catalysts is still the predominant technique for ammonia production despite tough reaction conditions and high energy consumption. In the present work, we have investigated iron adatom on the (110) surface of pure iron catalyst towards the electrocatalytic N2 reduction reaction (NRR) activity using density function theory (DFT) calculations. We demonstrate that the presence of adatom over the iron catalyst favours the NRR via alternating associative mechanistic pathway through a barrierless rate determining step (*NNH formation). Besides, the adatom‐based catalyst requires lower working potential than the previously reported Fe(110) surface and Fe‐nanocluster based catalysts. These findings may open a scope in terms of scrutinizing the atomicity effects over catalyst surface for various catalytic reactions.
Visible‐light‐responsive Photocatalyst Based on Nitrogen‐doped Bulk Oxide YTaO4−xNy for Z‐scheme Overall Water Splitting
Authors: Zou Hai , Bao Yunfeng , Du Shiwen , Xin Xueshang , Qi Yu , Shao Guosheng , Zhang Fuxiang 
Published: March 2023

AbstractNitrogen doping into oxide has been proved to be an effective strategy to extend visible‐light utilization of oxides with layered or channeled structure, but it is shortage for the bulk oxides free of layered or channeled structure. Here, we report a novel nitrogen‐doped bulk oxide (denoted as YTaO4−xNy) with good visible light response. As benefited from the strong hybridization of N 2p and O 2p electronic state according to the density functional theory (DFT) calculations, the band gap (3.6 eV) of YTaO4 precursor was sharply narrowed to 2.4 eV on YTaO4−xNy due to the obvious uplift of the valence band maximum (VBM). After decorated with the platinum cocatalyst, the Pt/YTaO4−xNy was used as the H2‐evolving photocatalyst for assembly of Z‐scheme overall water splitting system by coupling with the PtOx/WO3 as the oxygen evolution photocatalyst and using the I−/IO3− as the shuttle ions. This work enriches the material database of nitrogen‐doped oxide with wide visible light absorption and shows its promising application in solar‐to‐chemical conversion.
Are track recommendations dependent on schools and school boards? A study of trends in the level of track recommendations, number of double recommendations and reconsiderations in Dutch urban and rural areas
Authors: Timmermans A. C. , Dijks M. A. , Warrens M. J. 
Published: March 2023

AbstractTrack recommendations provided to students in the final grade of primary education lead the allocation to specific school tracks in secondary education in the Netherlands. Where the results of a standardised test indicate that students are able to go to a higher track level, primary schools are required to reconsider and potentially adjust the track recommendation to a higher level. The current research aimed to (1) investigate trends in the level of track recommendations, double track recommendations and reconsiderations over the years 2014–2015 to 2018–2019, (2) explore the variation in (trends of) track recommendations between Dutch primary schools and their school boards, and (3) assess the association between track recommendations and the school level variables degree of urbanisation and type of primary education. We used multilevel growth curve modelling for continuous and count data based on publicly available school‐level population data regarding track recommendations and school leavers tests from 2014–2015 to 2018–2019. The number of double track recommendations has increased over the cohorts, with a slightly decreasing gap between schools in rural and urban areas. The number of reconsiderations first decreased and then increased. The differences in reconsiderations between rural and urban areas are increasing over time. An initial trend towards higher average recommendations stabilising in the later cohorts appeared with no clear pattern for degree of urbanisation. The current study adds to the existing knowledge by assessing longitudinal trends instead of cross‐sectional analyses and including multiple stakeholders and factors simultaneously.
The impact of DNMT3A variant allele frequency and two different comutations on patients with de novo cytogenetically normal acute myeloid leukemia
Authors: Chen Xian , Tian Chuchu , Hao Zhuanghui , Pan Lingang , Hong Minglin , Wei Wei , Muyey Daniel Muteb , Wang Hongwei , Chen Xiuhua 
Published: March 2023

AbstractTo refine the biological and prognostic significance of DNMT3A mutations in acute myeloid leukemia (AML), we assessed the impact of DNMT3A variant allele frequency (VAF) and its comutations in this study. Using targeted next‐generation sequencing, we analyzed 171 adult patients with de novo cytogenetically normal AML for DNMT3A mutations and associated comutations. DNMT3Amut was detected in 35 patients. DNMT3Amut patients were divided into DNMT3AHigh and DNMT3ALow using a cut‐off VAF value of 42%. We observed that DNMT3AHigh patients at diagnosis had increasing white blood cell (WBC) counts (p < 0.001) and a higher lactate dehydrogenase (LDH) level (p = 0.027), and were associated with lower complete remission (CR) rate (p = 0.015) and shorter overall survival (OS) (p = 0.032) than DNMT3ALow patients. We classified two different comutated genetypes, including DNMT3AmutNPM1mutFLT3‐ITDmut and DNMT3AmutIDH1/IDH2mut. Patients with DNMT3AmutNPM1mutFLT3‐ITDmut showed worse OS (p = 0.026) and relapse‐free survival (RFS) (p = 0.003) than those with DNMT3AmutIDH1/IDH2mut, and showed a shorter OS (p = 0.027) than those with DNMT3AwtNPM1mutFLT3‐ITDmut. We also observed that patients with DNMT3AmutIDH1/IDH2mut had higher platelet counts (p = 0.009) and a lower BM blast percentage (p = 0.040) than those with DNMT3AwtIDH1/IDH2mut. In multivariate analyses, DNMT3AHigh was independently associated with a lower CR rate (OR = 5.883; p = 0.004) and shorter OS (HR = 3.768; p < 0.001). DNMT3AmutNPM1mutFLT3‐ITDmut independently affected worse OS (HR = 6.030; p < 0.001) and RFS (HR = 8.939; p < 0.001). Our findings might be potentially useful for predicting clinical outcomes.
Role of NF‐κB/IL‐1β Pathway and Caspase 3 in Mediating the Hepatoprotective Effect of Rutin against Paraquat‐Induced Liver Toxicity in Male Rats
Authors: Rafiee Sahar , Nouri Ali , Heidarian Esfandiar 
Published: March 2023

AbstractOne of the most common bipyridinium herbicides that can lead to liver toxicity is paraquat. Rutin is a bioflavonoid with antioxidant, anti‐inflammatory, anti‐hepatotoxic, and antimicrobial properties. The effect of rutin on paraquat‐induced liver toxicity was examined in this study. 48 male rats were divided into six groups: the control group was given a normal diet; the non‐treated group was given paraquat; the positive control group was given paraquat, and silymarin and the treatment groups were given paraquat and rutin at doses of 25, 50, and 100 mg/kg. After fourteen days, the rats were anesthetized by xylazine‐ketamine, and fasting blood samples were obtained from their hearts to measure alkaline phosphatase (ALP), aspartate transaminase (AST), alanine transaminase (ALT), malondialdehyde (MDA), creatinine, lipid profile, antioxidant capacity, and carbonyl protein. The liver tissue was removed to measure the levels of catalase (CAT), superoxide dismutase (SOD), total protein, vitamin C, plus NF‐κB, IL1β, and caspase‐3 gene expressions. Paraquat gavage in the untreated group (group 2) for 14 days in comparison with the control group induced a significant augmentation (p<0.05) in levels of lipid profile, AST, ALP, ALT, MDA, carbonyl protein, and also NF‐κB, IL1β, Caspase3 expressions. Treatment with rutin reduced the factors as mentioned above. Paraquat poisoning induced a substantial decline (p<0.05) in HDL content, FRAP level, CAT, and SOD activity of the liver compared to the control group. However, rutin oral treatment led to a substantial increase (p<0.05) in the level of these factors compared to the paraquat‐only treated group. Based on the findings of the present study, it was found that rutin can be significantly effective in improving hepatotoxicity caused by paraquat.
Phenylethanoid Glycosides from Caryopteris aureoglandulosa and Their Biological Activities
Authors: Chen Yi , Xu Hong‐Tao , Tian Tong , Wei Xiao‐Hui , Chou Gui‐Xin 
Published: March 2023

AbstractThis study describes the isolation and identification of two novel phenylethanoid glycosides, aureoglanduloside A (1) and aureoglanduloside B (2), as well as a newly discovered diterpene glycoside, aureoglanduloside C (29). Additionally, 31 known compounds were isolated from the n‐butyl alcohol (BuOH) soluble fraction of Caryopteris aureoglandulosa whole dried plants. Their structures were characterized using various spectroscopic techniques and high‐resolution electrospray ionization mass spectroscopy (HR‐ESI‐MS). Furthermore, the neuroprotective effects of all phenylethanoid glycosides were evaluated. Specifically, compounds 2 and 10–12 exhibited the ability to promote the phagocytosis of myelin by microglia, and compounds 2, 10–11, and 24 showed the ability to promote the phagocytosis of myelin by astrocytes.
Impact of degree of milling on cooking duration and textural attributes of long‐grain hybrid rice for instant rice processing
Authors: Okeyo Anne A. , Luthra Kaushik , Atungulu Griffiths G. 
Published: March 2023

AbstractBackground and ObjectivesDue to the emergence of new hybrid rice cultivars, rice product processors need to refine processing protocols to continue producing high‐quality products; this is especially true for the instant rice processing industry. This study develops knowledge that is meant to help understand the processing characteristics of new hybrid rice cultivars that are meant to be used for instant rice production. The objective of this study was to examine the effects of the degree of milling (DOM) on cooking durations and textural properties of new long‐grain (LG) hybrid rice to be used in instant rice processing.FindingsGelatinization of the new cultivars was affected by DOM (p < .0001). For milled rice, the cook duration estimated by the cooked rice moisture content (MC) relationship was comparable to data obtained from the common method of using gelatinized rice kernel to determine cook duration. However, the cook duration predicted based on cooked rice peak force relationships was significantly different (p < .05) for studied cultivars. For brown rice, the cook duration estimated by the cooked rice moisture content (MC) and peak force relationships were similar but significantly lower than that obtained by gelatinized rice kernel method. DOM did not affect the textural property values of cooked rice for the studied cultivars (p > .05).ConclusionsRice milled to a lesser degree took longer to gelatinize, while brown rice took the longest duration. The textural properties of cooked rice did not change significantly for different rice cultivars.Significance and NoveltyCook durations for milled and brown rice for newer LG hybrid rice cultivars (XL 753 and RT 7521 FP) were established. The study has provided information crucial to understanding the impacts of DOM on rice cooking duration and textural attributes of hybrid rice. This information is important for the instant rice processing industry.
Non‐eosinophilic asthma in nonsteroidal anti‐inflammatory drug exacerbated respiratory disease
Authors: Mastalerz Lucyna , Celejewska‐Wójcik Natalia , Ćmiel Adam , Wójcik Krzysztof , Szaleniec Joanna , Hydzik‐Sobocińska Karolina , Tomik Jerzy , Sanak Marek 
Published: March 2023

AbstractBackgroundThe cellular inflammatory pattern of nonsteroidal anti‐inflammatory drug–exacerbated respiratory disease (N‐ERD) is heterogeneous. However, data on the heterogeneity of non‐eosinophilic asthma (NEA) with aspirin hypersensitivity are scanty. By examination of N‐ERD patients based on clinical data and eicosanoid biomarkers we aimed to identify NEA endotypes potentially guiding clinical management.MethodsInduced sputum was collected from patients with N‐ERD. Sixty six patients (49.6% of 133 N‐ERD) with NEA were included in the hierarchical cluster analysis based on clinical and laboratory data. The quality of clustering was evaluated using internal cluster validation with different indices and a practical decision tree was proposed to simplify stratification of patients.ResultsThe most frequent NEA pattern was paucigranulocytic (PGA; 75.8%), remaining was neutrophilic asthma (NA; 24.2%). Four clusters were identified. Cluster #3 included the highest number of NEA patients (37.9%) with severe asthma and PGA pattern (96.0%). Cluster #1 (24.2%) included severe only asthma, with a higher prevalence of NA (50%). Cluster #2 (25.8%) comprised well‐controlled mild or severe asthma (PGA; 76.5%). Cluster #4 contained only 12.1% patients with well‐controlled moderate asthma (PGA; 62.5%). Sputum prostaglandin D2 levels distinguished cluster #1 from the remaining clusters with an area under the curve of 0.94.ConclusionsAmong identified four NEA subtypes, clusters #3 and #1 represented N‐ERD patients with severe asthma but a different inflammatory signatures. All the clusters were discriminated by sputum PGD2 levels, asthma severity, and age of patients. The heterogeneity of non‐eosinophilic N‐ERD suggests a need for novel targeted interventions.