bluuebunny/crossref_metadata_2025_split huggingface dataset:
Integrated molecular and clinical analysis of BRAF-mutant glioma in adults
Authors: Schreck Karisa C. , Langat Pinky , Bhave Varun M. , Li Taibo , Woodward Eleanor , Pratilas Christine A. , Eberhart Charles G. , Bi Wenya Linda 
Published: February 2023

AbstractBRAF mutations are a significant driver of disease in pediatric low-grade glioma, but the implications of BRAF alterations on the clinical course and treatment response in adult glioma remain unclear. Here, we characterize a multi-institutional cohort of more than 300 patients (>200 adults) with BRAF-mutated glioma using clinical, pathological/molecular, and outcome data. We observed that adult and pediatric BRAF-mutant gliomas harbor distinct clinical and molecular features, with a higher prevalence of BRAFV600E (Class I) and BRAF fusions in pediatric tumors. BRAFV600E alterations were associated with improved survival in adults with glioma overall, though not in glioblastoma. Other genomic alterations observed within functional classes were consistent with the putative roles of those BRAF mutation classes in glioma pathogenesis. In our adult cohort, BRAFV600E alterations conferred sensitivity to targeted therapies. Overall, this large cohort of BRAF-altered adult gliomas demonstrates a broad range of molecular alterations with implications for treatment sensitivity and survival.
Rapid and stable hydrogen detection based on Pd-modified WO3 nanosheets
Authors: Lv Jianxin , Zhang Linghui , Si Lianxi , Li Hui , Zhao Wenbo , An Fei , Feng Xia , Hu Shi 
Published: February 2023

The combination of the 2D ultrathin structure of WO3 and the catalytic effect of Pd endow Pd/WO3 with rapid and stable hydrogen detection.
TLR2 and 4 signaling pathways are altered in macrophages from V30M TTR mice with down-regulated expression of chemokines
Authors: Moreira João , Martins Helena , Saraiva Margarida , Saraiva Maria João 
Published: February 2023

Abstract
Hereditary amyloid transthyretin (ATTRv) amyloidosis is a fatal neurodegenerative disorder, first identified in Portugal. The most common transthyretin (TTR) mutation in ATTRv results from an exchange of a methionine for a valine at position 30 (V30M). ATTRv is characterized by the extracellular deposition of aggregates and fibrils of mutant forms of TTR, particularly in the nerves and ganglia of the peripheral nervous system (PNS). This phenotype is often accompanied by the lack of inflammatory infiltrates, despite the importance of macrophages in removal of TTR deposits in ATTRv patients. The mechanisms underlying this impairment of inflammatory responses in ATTRv patients are poorly understood.
Here, we show a significant down-regulation in the expression of several chemokines by bone marrow-derived macrophages (BMDM) generated from V30M TTR mice upon stimulation with toll-like receptor 4 (TLR4) and TLR2 agonists. The phosphorylation of the MAP kinase p38, important for TLR4 and TLR2 signaling pathways, was also down-regulated in V30M macrophages, as compared with wild-type (WT) ones.
The present study contributes with new insights to unravel the molecular mechanisms underlying the lack of inflammatory immune responses observed in ATTRv patients and may help in the development of new immune therapeutic strategies for the disease.
Carte du Ciel andGaia
Authors: Lehtinen K. , Prusti T. , de Bruijne J. , Lammers U. , Manara C. F. , Ness J.-U. , Siddiqui H. , Poutanen M. , Muinonen K. , Morrison O. 
Published: February 2023

Context.The Carte du Ciel archive at the University of Helsinki enables us to see the sky as it was about 120 yr ago. The archive consists of single-exposure and triple-exposure plates between epochs 1896.8–1925.8.Aims.Our main aim is to find binary and multiple stars by combining Carte du Ciel andGaiadata.Methods.The plates were digitised with a commercial digital camera. We usedGaiadata to calculate predicted coordinates of stars at the epoch of each plate. These stars were used as reference stars to fit astrometry for each plate, giving fitted coordinates for stars on the Carte du Ciel plates. If the predicted and fitted coordinates differed at a significant level, we classified the star as a non-single star, for which the proper motion values given in theGaiacatalogue can be unreliable.Results.We find that several astrometric quality indicators ofGaiaindicate that the uncertainties ofGaia’ssingle-star model fit are, in general, larger for our non-single-star candidates. The percentage of our non-single-star candidates, which are in the catalogues of known binary stars, is relatively low, ~10% at maximum.Conclusions.The combination of the Carte du Ciel andGaiadata can be used to identify candidates of non-single stars. We propose that the sources with a significant difference between the predicted and fitted coordinates are long-period binaries, although astrophysical and/or instrumental effects as origin for the coordinate difference cannot be excluded for individual cases.
Autoimmunpankreatitis
Authors: Juchems Markus , Schreyer Andreas G. , Wessling Johannes , Ringe Kristina , Grenacher Lars 
Published: February 2023

ZusammenfassungSeit den 1990er-Jahren ist die Autoimmunpankreatitis (AIP) als eigenständige Form der Pankreatitis bekannt, seit Kurzem ist sie als solche auch anerkannt. In diesem Beitrag liegt der Schwerpunkt auf der Diagnostik der Autoimmunpankreatitis und dabei insbesondere auf der Bildgebung, die dabei eine entscheidende Rolle spielt.
Die Bedeutung des Transkriptionsfaktors Brachyury in Chordomen
Authors: Seeling Carolin , Möller Peter , Barth Thomas F.E. , Mellert Kevin 
Published: February 2023

ZusammenfassungChordome sind seltene, maligne Knochentumoren, die vermutlich embryonalen
Überresten der Chorda dorsalis entstammen. Ein wesentliches Argument
für diese Annahme ist die gemeinsame Expression des
Transkriptionsfaktors Brachyury.Während Brachyury im Rahmen der Embryonalentwicklung für die
Ausbildung der anterior-posterioren Achse von fundamentaler Bedeutung ist, legen
neueste Studien nahe, dass Brachyury auch für das Überleben von
Chordomen essenziell ist.Dieser Beitrag liefert eine Übersicht über die physiologischen
und onkogenen Funktionen von Brachyury und diskutiert die sich hieraus
ableitenden therapeutischen Ansatzpunkte in Chordomen.
Etablierung eines Kollektivs zur histomorphologischen Risikostratifizierung von
Riesenzelltumoren mit und ohne Denosumab-Therapie
Authors: Arndt S. , Hartmann W. , Rókusz A. , Leinauer B. , von Baer A. , Schultheiss M. , Pablik J. , Fritzsche H. , Mogler C. , Baumhoer D. , Mellert K. , Möller P. , Sendrói M. , Jundt G. , Barth T.F. 
Published: February 2023

ZusammenfassungIn den letzten Jahren wurden bedeutsame Daten zur Biologie und Therapie des
Riesenzelltumor des Knochens (RZTK) veröffentlicht. Ein entscheidender
Durchbruch für die Diagnostik von RZTK war die Entdeckung der hoch
tumorcharakteristischen Mutation im H3F3A-Gen, die zum
Aminosäureaustausch G34W im Histon H3 führt. Zudem konnte sich in der
Therapie die Behandlung von inoperablen RZTK mit dem anti-RANKL Antikörper
Denosumab etablieren. Im Zusammenhang mit einer Denosumab-Therapie gibt es allerdings
auch Berichte einer malignen Transformation des Tumors, wobei der konkrete Einfluss von
Denosumab nicht eindeutig geklärt ist. Die Arbeitsgemeinschaft Knochentumoren
(AGKT e. V.) hat daher eine multi-institutionelle Studie initiiert, um ein
Kollektiv von RZTK zu etablieren mit dem Ziel a) morphologische Veränderungen
unter Denosumab-Therapie detailliert zu beschreiben; b) Faktoren hinsichtlich einer
potentiellen Malignisierung in ein Sarkom im Sinne einer Risikostratifizierung zu
identifizieren; c) im direkten Vergleich RZTK im Rezidiv zu analysieren und
mögliche Risikofaktoren hinsichtlich eines Rezidivs zu erarbeiten. Dafür
wurden 26 RZTK vor und nach Denosumab-Therapie und 14 RZTK im Vergleich Primarius zu
Rezidiv ohne Denosumab-Behandlung paarweise in die Studie eingeschlossen. Eingesetzte
Techniken sind zunächst die histologische Beurteilung der morphologischen
Veränderungen und die immunhistologische Analyse mittels eines breiten Panels an
Markern. Das klinisch gut definierte Kollektiv soll im weiteren als Grundlage
für eine Daten- und Gewebebank für zusätzliche
molekularpathologische Analysen dienen.
Update Mammakarzinom 2022 Teil 4 – Brustkrebs in fortgeschrittenen Krankheitsstadien
Authors: Aktas Bahriye , Fehm Tanja N. , Welslau Manfred , Müller Volkmar , Lüftner Diana , Schütz Florian , Fasching Peter A. , Janni Wolfgang , Thomssen Christoph , Witzel Isabell , Belleville Erik , Untch Michael , Thill Marc , Tesch Hans , Ditsch Nina , Lux Michael P. , Banys-Paluchowski Maggie , Kolberg-Liedtke Cornelia , Hartkopf Andreas D. , Wöckel Achim , Kolberg Hans-Christian , Stickeler Elmar , Harbeck Nadia , Schneeweiss Andreas 
Published: February 2023

ZusammenfassungFür die Behandlung von Patientinnen mit fortgeschrittenem HER2-negativem, hormonrezeptorpositivem Mammakarzinom sind in den letzten Jahren einige Substanzen in die Praxis eingeführt worden. Zusätzlich sind weitere Medikamente in der Entwicklung. Im letzten Jahr sind einige Studien veröffentlicht worden, die entweder einen Vorteil für das progressionsfreie Überleben oder aber auch für das Gesamtüberleben gezeigt haben. Diese Übersichtsarbeit fasst die neuesten Ergebnisse, welche auf aktuellen Kongressen oder in Fachzeitschriften veröffentlicht wurden, zusammen und ordnet sie in den klinischen Behandlungskontext ein. Insbesondere wird auf den Stellenwert einer Therapie mit CDK4/6 Inhibitoren, Trastuzumab-Deruxtecan, Sacituzumab-Govitecan und Capivasertib eingegangen. Für Trastuzumab-Deruxtecan wurde in der Destiny-Breast-04-Studie ein Gesamtüberlebensvorteil bei HER2-negativem Mammakarzinom mit einer niedrigen HER2-Expression (HER2-low expression) berichtet. Ebenso konnte ein Gesamtüberlebensvorteil in der FAKTION-Studie mit Capivasertib verzeichnet werden. Nach dem fehlenden Gesamtüberlebensvorteil für Palbociclib in der 1. Therapielinie stellt sich hier die Frage nach der klinischen Einordnung.
Endoprothetische Versorgung von Patienten mit
Skelettdysplasien
Authors: Seefried Lothar 
Published: February 2023

ZusammenfassungSkelettdysplasien sind häufig assoziiert mit einem hohen Risiko
für Gelenkschäden und Arthrose insbesondere der großen
Gelenke. Ursache sind je nach Erkrankung in unterschiedlichem Ausmaß
sowohl die unterliegenden Stoffwechselstörungen selbst als auch die
assoziierten Deformierungen mit konsekutiv häufig unvorteilhafter
biomechanischer Belastungssituation. Dadurch ergibt sich bei diesen Patienten
regelhaft die Indikation für eine endoprothetische Versorgung und damit
verbunden die Frage, ob und wie bzw. unter welchen Voraussetzungen eine solche
sicher und nachhaltig durchgeführt werden kann. Wesentliche
Herausforderungen in Abweichung von der sonstigen endoprothetischen
Routineversorgung sind in diesem Kontext die regelhaft veränderten
anatomischen und biomechanischen Verhältnisse, häufig mit
Kleinwuchs und der Notwendigkeit entsprechend dimensionierter und ggf. auch
anatomisch konfigurierter Implantate. Hinzu kommen erforderliche
Überlegungen zu den jeweils geeigneten Möglichkeiten der
knöchernen Verankerung vor dem Hintergrund der oftmals kompromittierten
Knochenbiologie, verbunden mit der Frage nach perioperativen
Verbesserungsmöglichkeiten. Regelhaft müssen dabei auch die
Folgen und Implikationen aus früheren Interventionen mit
berücksichtigt werden. Dabei gilt es, perspektivisch auch die
individuell und erkrankungsspezifisch divergierenden Limitationen bzgl. der
postoperativen Rehabilitation und prognostisch absehbare weitere Operationen
frühzeitig in die Überlegungen mit einzubeziehen. Am Beispiel
vergleichsweise häufiger Skelettdyslasien wie der Osteogenesis
Imperfecta (OI), der Hyspophosphatasie (HPP) und der X-chromosomalen
Hypophosphatasie (XLH) werden im Folgenden konkrete Überlegungen und
Konzepte in diesem Zusammenhang dargestellt und diskutiert.
Facile Synthesis of Isoindolinones via Radical-Mediated Intramolecular Coupling of Two C–H Bonds
Authors: Zhao Yingsheng , Chen Gong , Han Shuxiong , He Shuo , Huang Zhibin 
Published: February 2023

AbstractA metal-free method for the construction of 3,3-dimethyl isoindolinones via radical-mediated intramolecular coupling of two C–H bonds of N,N-diisopropyl benzamides was developed. The reactions can proceed in moderate to high yield and with excellent chemoselectivity. A reaction sequence of the formation of an alkyl radical via oxidative cleavage of alkyl C–H bond and the formation of lactam ring via intramolecular homolytic aromatic substitution was proposed.
Processed cassava peel–leaf blends: effect on performance, carcass yield, organ weights and ileal microflora of growing pigs
Authors: Williams Gabriel Adedotun , Akinola Olufemi Sunday , Adeleye Titilayo Modupe , Irekhore Oluwakemi Tinuke , Lala Adebukunola Olufunmilayo , Oso Abimbola Oladele 
Published: February 2023

Context The cost of feedstuff such as maize and other conventional energy sources has increased due to high competitive demand, which necessitated the search into alternative feedstuff such as cassava by-products (peel and leaf). However, their nutrient availability is hampered by antinutritional factors and constituent fibre. Aims This study investigated the effect of dietary inclusion of differently processed cassava peel–leaf blend (CPLB) on performance, carcass yield, organ weights and ileal microflora of growing pigs. Methods Cassava peel:cassava leaf (CPLB; 5:1) was included in the pigs’ diet in a feeding trial for 16 weeks. The CPLB replaced maize at 100%. Twenty-four pigs of mean weight range (20–22 kg) were assigned on a weight-equalisation basis to four dietary treatments having six replicates, with one pig per replicate. A standard corn soya-based diet (control), unfermented CPLB (UCPLB), water-fermented CPLB (WCPLB) and microbial-fermented CPLB (MCPLB) using Aspergillus tamarii as the inoculum was formulated. Performance was measured weekly, while carcass yield, organ weights and ileal microbial count were measured at the end of the 16th week. Key results Dietary inclusion of WCPLB and MCPLB reduced (P < 0.05) carcass weight. Pigs fed control diet and those fed diet containing UCPLB had a similar dressing percentage, while those fed diet containing MCPLB had an intermediate dressing percentage to those fed control diet and those fed diet containing WCPLB. Reduced (P < 0.05) Escherichia coli count (3.30 and 3.36 log10) was obtained in the ileum content of pigs fed diet containing UCPLB and WCPLB respectively. Conclusion Dietary replacement of CPLB for maize did not affect performance of pigs significantly and inclusion of UCPLB in the diet of pigs resulted in a comparable dressing percentage that for pigs fed control diet. Implication This study will help researchers on the right combination of the by-product without detrimental effect on carcass yield, and also encourage the farmer on utilisation of the by-product in pig feeding.
Material strategies to enhance the performance of piezoelectric energy harvesters based on lead-free materials
Authors: Bartasyte Ausrine , Clementi Giacomo , Micard Quentin , Labbaveettil Ishamol , Moreira Arthur Sousa Lopes , Boujnah Sondes , Ouhabaz Merieme , Verma Anjenya , Ichangi Arun , Malandrino Graziella , Mathur Sanjay , Dulmet Bernard , Margueron Samuel 
Published: February 2023

Abstract
Over the past four decades, energy microsources based on piezoelectric energy harvesting have been intensively studied for applications in autonomous sensor systems. The research is triggered by the request for replacing standard lead-based piezoelectric ceramics with environmentally friendly lead-free materials and potential deployment of energy-harvesting microsystems in internet of things, internet of health, ‘place and leave’ sensors in infrastructures and agriculture monitoring. Moreover, futher system miniaturization and co-integration of functions are required in line with a desired possibility to increase the harvested power density per material volume. Thus, further research efforts are necessary to develop more sustainable materials/systems with high-performance. This paper gives a comprehensive overview on the processing and functional testing the lead-free bulk materials and thin films and discusses their potential in the applications in the stress- and strain-driven piezoelectric energy harvesting. This includes the methodology of estimation of the substrate clamping and orientation/texture effects in the thin films, and identification of orientations offering high figure of merit. The ability to control film orientation of different lead-free materials is reviewed and the expected piezoelectric performances are compared with the ones reported in literature.
Identification and suppression of driving force misalignment angle for a MEMS gyroscope using parametric excitation
Authors: Zheng Xudong , Wang Xuetong , Shen Yaojie , Xia Chenhao , Tong Wenyuan , Jin Zhonghe , Ma Zhipeng 
Published: February 2023

Abstract
We report for the first time an implementable method to identify and suppress the driving force misalignment angle for a MEMS gyroscope working either in amplitude modulated (AM) or Lissajous frequency modulated (LFM) mode using parametric excitation. By introducing driving force misalignment angle into gyroscope dynamic equations, we illustrate that gyroscope angular rate output is affected by driving force misalignment angle and cross-axis damping jointly. We propose parametric excitation as a way to both identify and calculate the driving force misalignment angle. The identification results for a gyroscope working in both AM and LFM mode are similar, which indicates the effectiveness of the proposed identification method. Instead of using traditional amplitude control loop by adjusting the driving force, we do the automatic gain control by adjusting the parametric pump voltage so that a fixed drive voltage can be used, which also indicates fixed force coupling. Experimental results show that after suppression, the bias instability (BI) of AM mode is improved from 4.7° h−1 to 2.3° h−1 and the BI of LFM mode is improved from 1.4° h−1 to 0.9° h−1 which is the lowest result reported for LFM gyroscope.
Breakdown mode and parameter space of micro-discharge sustained by thermionic emission
Authors: Li Xiandi , Wu Hao , Zhong Yujie , Guo Chengzhi , Yi Lin , Jiang Wei , Zhang Ya 
Published: February 2023

Abstract
Gas breakdown driven by thermionic emission in a microgap to produce low-temperature plasma is studied using a 1D implicit particle-in-cell/Monte Carlo collision model. The influence of background gas pressure, external driving voltage, cathode temperature and discharge gap on argon glow micro-discharge in the parallel plate was simulated. Different parameters and conditions have different effects on the gas breakdown at small size. The discharge gap of hundreds of µm has little influence on the gas breakdown and only changes the plasma distribution. As the applied voltage increases, the gas changes from a non-breakdown mode to a breakdown mode, and the gas breakdown is more sensitive to the applied voltage than the gas pressure at low voltages. In all breakdown modes, the gas pressure hardly changes the plasma evolution characteristics. At appropriate cathode temperatures, the density of electrons and ions increases rapidly, forming a stable sheath, and the equivalent resistance of the discharge gap becomes smaller as the temperature rises and the plasma is in abnormal glow discharge.
Comment on ‘Q-BOR-FDTD method for solving Schrödinger equation for rotationally symmetric nanostructures with hydrogenic impurity’
Authors: Fernández Francisco M 
Published: February 2023

Abstract
We discuss a recently proposed approach termed Q-BOR-FDTD method and argue that it is unsuitable for spherically-symmetric potentials. More precisely, we cast doubt on the excited-state eigenfunctions obtained for such quantum-mechanical models and propose an improvement for their treatment.
Low threshold lasing in Al-decorated GaN microdisk on silicon substrate
Authors: Qin Feifei , Gao Fei , Zhou Mengyao , Li Xin , Wang Ru , Wang Xiaoxuan , Lu Jun Feng , Shan Yaqi , Wang Yongjin , Zhu Gangyi 
Published: February 2023

Abstract
In spite of the unique advantages of nitride microcavities laser, the optical loss and threshed values are still high in most GaN microdisk laser integrated on silicon substrate. Herein, we fabricated a GaN microdisk cavity pivoted on Si substrate using standard semiconductor process. Al nanoparticles (NPs) with diameter below 100 nm were then decorated on the GaN cavity as surface plasmons (SPs) gain to enhance the lasing performance. SPs coupling properties and photoluminescence (PL) enhancement of Al decorated cavities were studied via excitation power-dependent PL and time-resolved PL measurements. Low optical loss caused by device suspension and SPs coupling induced Purcell Factor enhancement significantly improve the lasing properties. A spontaneous enhancement in PL (by 1.75 folds) along with altered lasing characteristics, including accelerated exciton recombination, reduced lasing threshold value (by 5 folds approximately), slight lasing intensity improvement and redshift of the resonant mode, were observed.
Tidal effects in black hole of non-linear electrodynamic field
Authors: Abbas G , Asgher M 
Published: February 2023

Abstract
Tidal forces are most significant feature of geodesic deviation in General Relativity. The astrophysical significance within tidal forces, standpoints out tidal disruption events. We investigate the tidal forces developed in black hole formulated in nonlinear electrodynamic theory. With increasing the charge of black hole, the radial and angular components of the geodesic deviation vector increase. The components of tidal force has been obtained by Riemann tensor and geodesic deviation equation. We solve the geodesic deviation equation for radial and angular components of an exact black hole spacetime. Further, we explore the graphical behavior of radial and angular components for different initial conditions and black hole parameters.
Probing neutrino interactions and dark radiation with gravitational waves
Authors: Loverde Marilena , Weiner Zachary J. 
Published: February 2023

Abstract
After their generation, cosmological backgrounds of gravitational waves propagate nearly
freely but for the expansion of the Universe and the anisotropic stress of free-streaming
particles. Primordial signals — both that from inflation and the infrared spectrum associated to
subhorizon production mechanisms — would carry clean information about the cosmological history of
these effects. We study the modulation of the standard damping of gravitational waves by
free-streaming radiation due to the decoupling (or recoupling) of interactions. We focus on
nonstandard neutrino interactions in effect after the decoupling of weak interactions as well as
more general scenarios in the early Universe involving other light relics. We develop
semianalytic results in fully free-streaming scenarios to provide intuition for numerical results
that incorporate interaction rates with a variety of temperature dependencies. Finally, we
compute the imprint of neutrino interactions on the B-mode polarization of the cosmic microwave
background, and we comment on other means to infer the presence of such effects at higher
frequencies.