bluuebunny/crossref_metadata_2025_split huggingface dataset:
Patient and primary care practitioners’ perspectives on consultations for fibromyalgia: a qualitative evidence synthesis
Authors: Byrne Ailish , Jones Katherine , Backhouse Michael , Rose Fiona , Moatt Emma , van der Feltz-Cornelis Christina 
Published: September 2023

Abstract

Background:
Fibromyalgia presents a challenge to both the patients experiencing symptoms and the staff aiming to treat them. This qualitative review aimed to synthesise how patients and practitioners experience primary care consultations, develop a rounded picture of how they perceive each other, the challenges to primary care consultation and how they might be tackled.

Methods:
CINAHL, Embase, CENTRAL and Medline were searched from inception to November 2021. Qualitative studies were included if they explored the perspectives and experiences of either fibromyalgia patients or primary care practitioners. Quantitative data, studies not published in English, not set in primary care or that did not distinguish the type of patient or clinician were excluded. Included studies were analysed using thematic synthesis and their quality assessed.

Results:
In total, 30 studies met the inclusion criteria. Thematic synthesis identified three overarching themes: (1) life turned upside down – exploring the chaos experienced by patients as they seek help; (2) negative cycle – highlighting how patient and practitioner factors can create a detrimental cycle; and (3) breaking the cycle – validating patient–doctor relationships underpinned by clear communication can help break the negative cycle.

Conclusions:
Fibromyalgia patients experience uncertainty and chaos that can clash with the attitudes of GPs and the help they can feasibly provide. Difficult consultations in which neither the GP nor patient are satisfied can easily occur. Promoting supportive, reciprocal and open patient–doctor relationships is essential. Future research is required to further explore GP attitudes and to develop an intervention that could improve consultations, patient outcomes and GP satisfaction.
Exploring the Connections between Confidence in the Digital/Online Future and Changes in Anglican Clergy Psychological Well-being during the Third Covid Lockdown in England during 2021
Authors: Francis Leslie J. , Village Andrew 
Published: September 2023

Abstract
Inspired by the objectives of the Church of England’s Living Ministry Research Project (to understand the factors that enable clergy to flourish and to understand how these factors vary according to person, background, etc.), the present analyses were designed to test the capacity of an individual differences approach to the science of clergy well-being for delivering such objectives. The specific case in point concerned understanding the connections between migration to digital technology and changes in clergy well-being during the pandemic. The data demonstrated how the individual differences approach both offered explanatory power and provided insights into how personal support and professional development could be most effectively structured and targeted.
Anthropogenic Aerosols Delay the Emergence of GHGs‐Forced Wetting of South Asian Rainy Seasons Under a Fossil‐Fuel Intensive Pathway
Authors: Singh Jitendra , Cook Benjamin I. , Marvel Kate , McDermid Sonali , Persad Geeta G. , Rajaratnam Bala , Singh Deepti 
Published: September 2023

AbstractWith continued fossil‐fuel dependence, anthropogenic aerosols over South Asia are projected to increase until the mid‐21st century along with greenhouse gases (GHGs). Using the Community Earth System Model (CESM1) Large Ensemble, we quantify the influence of aerosols and GHGs on South Asian seasonal precipitation patterns over the 21st century under a very high‐emissions (RCP 8.5) trajectory. We find that increasing local aerosol concentrations could continue to suppress precipitation over South Asia in the near‐term, delaying the emergence of precipitation increases in response to GHGs by several decades in the monsoon season and a decade in the post‐monsoon season. Emergence of this wetting signal is expected in both seasons by the mid‐21st century. Our results demonstrate that the trajectory of local aerosols together with GHGs will shape near‐future precipitation patterns over South Asia. Therefore, constraining precipitation response to different trajectories of both forcers is critical for informing near‐term adaptation efforts.
Regional Features of the 20–30 Day Periodic Behavior in the Southern Hemisphere Summer Circulation
Authors: Liu Zhaoyu , Wang Lei 
Published: September 2023

AbstractThe Southern Hemispheric storm tracks exhibit a robust intraseasonal periodicity of 20–30 days as the leading mode of zonal‐mean eddy kinetic energy. To what extent this hemispheric‐scale mode of variability translates to smaller scales remains debated. This work studies the regional features of Southern Hemisphere storm tracks through a filtered variance analysis of local finite‐amplitude wave activity. While the synoptic variance is zonally elongated over the storm track, we find a strong enhancement of intraseasonal variability within the South Pacific. With a minimum strength of the storm track, this region is marked with 20–30 day periodic behavior of local wave activity and precipitation and is driven by enhanced variability of low‐level eddy heat flux on the same timescale. The local nature of 20–30 day periodicity offers a potential source of subseasonal to seasonal predictability for weather analysts and forecasters.
On the Influence of Hydroxyl Radical Changes and Ocean Sinks on Estimated HCFC and HFC Emissions and Banks
Authors: Wang Peidong , Solomon Susan , Lickley Megan , Scott Jeffery R. , Weiss Ray F. , Prinn Ronald G. 
Published: September 2023

AbstractHydrochlorofluorocarbons (HCFCs) and hydrofluorocarbons (HFCs) are potent greenhouse gases regulated under the Montreal Protocol and its amendments. Emission estimates generally use constant atmospheric lifetimes accounting for loss via hydroxyl radical (OH) reactions. However, chemistry‐climate models suggest OH increases after 1980, implying underestimated emissions. Further, HCFCs and HFCs are soluble in seawater and could be destroyed through in situ oceanic microbial activity. These ocean sinks are largely overlooked. Using a coupled atmosphere‐ocean model, we show that increases in modeled OH imply underestimated HCFC and HFC emissions by ∼10% near their respective peak emissions. Our model results also suggest that oceanic processes could lead to up to an additional 10% underestimation in these halocarbon emissions in the 2020s. Ensuring global compliance to the Protocol and accurate knowledge of contributions to global warming from these gases therefore requires understanding of these processes.
Energetic Electron Precipitation During Slot Region Filling Events
Authors: Nesse H. , Babu E. M. , Salice J. A. , Funke B. 
Published: September 2023

AbstractThe slot region marks the equatorward boundary of the energetic electron precipitation (EEP). There are, however, numerous reports where energetic electrons cross these boundaries and fill the slot region. The ensuing EEP will occur long after the geomagnetic activity subsides. This is a missing energy input in current EEP estimates scaled by geomagnetic indices. This study explores the occurrence rate, duration, and local time dependence of slot region filling events using observations from the National Oceanic and Atmospheric Administration/Polar Orbiting Environmental Satellites over a full solar cycle from 2004 to 2014. The EEP flux estimates are based on the Medium Energy Proton Electron Detector 0° and 90° detectors and the theory of pitch angle diffusion by wave‐particle interaction. The occurrence rates of >43, >114, and >292 keV events are found to be strongly energy and solar cycle dependent. Higher energy events are more likely to be associated with Coronal Mass Ejections and stronger geomagnetic deflections compared to lower energy events. Solar wind speed, Bz, and Ey reveal a calm period before the events, potentially important for preconditioning the ensuing magnetospheric mass convection. The slot region reforms more efficiently closer to the plasmapause, which creates a double EEP band throughout the recovery period. The slot region EEP maximizes around noon throughout the afternoon/evening sector, consistent with pitch angle scattering from plasmaspheric hiss and lightning induced whistler mode waves. Concurrent with slot region filling events, the Michelson Interferometer for Passive Atmospheric Sounding/Envisat nitric oxide density show an increase at <55° corrected geomagnetic latitudes. This demonstrates the importance of including slot region EEP when assessing the EEP impact on the atmosphere.
Plasmasphere Control of ULF Wave Distribution at Different Geomagnetic Conditions
Authors: Rubtsov A. V. , Nosé M. , Matsuoka A. , Kasahara Y. , Kumamoto A. , Tsuchiya F. , Shinohara I. , Miyoshi Y. 
Published: September 2023

AbstractMagnetic storms and substorms cause global disturbances in the Earth's magnetosphere. Plasma clouds injected from the magnetotail during storm or substorm drift around the Earth and generate ultra‐low frequency (ULF) waves via various mechanisms. At the same time, the inner part of the magnetosphere called plasmasphere is filled with cold particles and its characteristics are sensitive to the geomagnetic activity level. Previous theoretical and some observational studies suggested plasmasphere and its boundary, plasmapause, are special regions for ULF waves to interact with charged particles. We present a statistical analysis of ULF waves during different geomagnetic conditions. We utilized Arase satellite magnetic field and electron density measurements from March 2017 to December 2020 to investigate spatial distribution of ULF waves and its dependence on the plasmapause location. A 1–2 RE gap between the plasmapause and a region of high transverse waves occurrence rate was found. This gap keeps during quiet geomagnetic conditions when plasmasphere expands, and we concluded that the plasmapause controls the ULF wave distribution in the magnetosphere. ULF wave occurrence rate significantly decreases at quiet time, but dayside and dawnside maxima still occur for poloidal and compressional, and toroidal waves, respectively. Thus, we can distinguish internally and externally excited waves. Average wave frequency distribution revealed field‐line resonance character of toroidal waves as frequency increases toward the Earth. Poloidal and compressional waves distributions clearly distinguish low frequency externally excited waves and high frequency storm‐time pulsations.
A Scaling for the Permeability of Loose Magma Mush Validated Using X‐Ray Computed Tomography of Packed Confectionary in 3D and Estimation Methods From 2D Crystal Shapes
Authors: Bretagne Eloïse , Wadsworth Fabian B. , Vasseur Jérémie , Dobson Katherine J. 
Published: September 2023

AbstractMelt percolation through partially molten “mushy” regions of the crust underpins models for magma migration, accumulation, and processes that prime systems for eruption. Knowledge of the hydraulic properties of magma mush, specifically permeability, is required for accurate predictions of melt migration rates and accumulation timescales. Previous studies, validated for cuboidal crystal analogs, show that crystal shape exerts a first‐order control on the permeability, and is tested here for anisometric natural crystal shapes using X‐ray CT 3D data sets of magma mush analogs made from packed confectionary particles arranged randomly. We use a lattice‐Boltzmann fluid flow simulation tool to determine the permeability of the analogue melt phase network between the packed particles. We find excellent agreement with our data sets to within ∼0.1 log units, when the specific surface area is measured. To extend this to more typical cases where the specific surface area is unknown, we use the shape and size of the objects determined in both 3D and 2D to estimate the specific surface area assuming a cuboid approximation. These approximate solutions give good results to within ∼0.5 log units of the measured permeability and offer a method by which permeability could be estimated from a thin section of a cumulate or pluton sample. Our shape‐sensitive approach is more accurate than existing models for permeability of magma mush, most approximating natural crystal shapes to spheres. We therefore propose that these could be implemented in dynamic magma mush models for melt movement in the crust to produce more accurate flux predictions.
GPER deletion triggers inhibitory effects in triple negative breast cancer (TNBC) cells through the JNK/c-Jun/p53/Noxa transduction pathway
Authors: Cirillo Francesca , Talia Marianna , Santolla Maria Francesca , Pellegrino Michele , Scordamaglia Domenica , Spinelli Asia , De Rosis Salvatore , Giordano Francesca , Muglia Lucia , Zicarelli Azzurra , Di Dio Marika , Rigiracciolo Damiano Cosimo , Miglietta Anna Maria , Filippelli Gianfranco , De Francesco Ernestina Marianna , Belfiore Antonino , Lappano Rosamaria , Maggiolini Marcello 
Published: September 2023

AbstractThe G protein-coupled estrogen receptor (GPER) mediates estrogen action in different pathophysiological conditions, including cancer. GPER expression and signaling have been found to join in the progression of triple-negative breast cancer (TNBC), even though controversial data have been reported. In present study, we aimed at providing new mechanistic and biological discoveries knocking out (KO) GPER expression by CRISPR/Cas9 technology in MDA-MB-231 TNBC cells. GPER KO whole transcriptome respect to wild type (WT) MDA-MB-231 cells was determined through total RNA sequencing (RNA-Seq) and gene ontology (GO) enrichment analysis. We ascertained that anti-proliferative and pro-apoptotic gene signatures characterize GPER KO MDA-MB-231 cells. Thereafter, we determined that these cells exhibit a reduced proliferative, clonogenic and self-renewal potential along with an increased mitochondria-dependent apoptosis phenotype. In addition, we recognized that decreased cAMP levels trigger the JNK/c-Jun/p53/Noxa axis, which in turn orchestrates the pro-apoptotic effects observed in GPER KO cells. In accordance with these data, survival analyses in TNBC patients of the Molecular Taxonomy of Breast Cancer International Consortium (METABRIC) dataset indicated that high Noxa expression correlates with improved outcomes in TNBC patients. Furthermore, we demonstrated that GPER KO in TNBC cells impairs the expression and secretion of the well-acknowledged GPER target gene named CTGF, thus resulting in the inhibition of migratory effects in cancer-associated fibroblasts (CAFs). Overall, the present study provides novel mechanistic and biological insights on GPER KO in TNBC cells suggesting that GPER may be considered as a valuable target in comprehensive therapeutic approaches halting TNBC progression.
Ictogenesis proceeds through discrete phases in hippocampal CA1 seizures in mice
Authors: Mueller John-Sebastian , Tescarollo Fabio C. , Huynh Trong , Brenner Daniel A. , Valdivia Daniel J. , Olagbegi Kanyin , Sangappa Sahana , Chen Spencer C. , Sun Hai 
Published: September 2023

AbstractEpilepsy is characterized by spontaneous non-provoked seizures, yet the mechanisms that trigger a seizure and allow its evolution remain underexplored. To dissect out phases of ictogenesis, we evoked hypersynchronous activity with optogenetic stimulation. Focal optogenetic activation of putative excitatory neurons in the mouse hippocampal CA1 reliably evoked convulsive seizures in awake mice. A time-vs-time pulsogram plot characterized the evolution of the EEG pulse response from a light evoked response to induced seizure activity. Our results depict ictogenesis as a stepwise process comprised of three distinctive phases demarcated by two transition points. The induction phase undergoes the first transition to reverberant phase activity, followed by the second transition into the paroxysmal phase or a seizure. Non-seizure responses are confined to either induction or reverberant phases. The pulsogram was then constructed in seizures recorded from a murine model of temporal lobe epilepsy and it depicted a similar reverberance preceding spontaneous seizures. The discovery of these distinct phases of ictogenesis may offer means to abort a seizure before it develops.
Divergent Deborah number-dependent transition from homogeneity to heterogeneity
Authors: Xu Dan , Yang Yang , Emmerich Lukas , Wang Yong , Zhang Kai 
Published: September 2023

AbstractHeterogeneous structures are ubiquitous in natural organisms. Native heterogeneous structures inspire many artificial structures that are playing important roles in modern society, while it is challenging to identify the relevant factors in forming these structures due to the complexity of living systems. Here, hybrid hydrogels consisting of flexible polymer networks with embedded stiff cellulose nanocrystals (CNCs) are considered an open system to simulate the generalized formation of heterogeneous core-sheath structures. As the result of the modified air drying process of hybrid hydrogels, the formation of heterogeneous core-sheath structure is found to be correlated to the relative evaporation speed. Specifically, the formation of such heterogeneity in xerogel fibers is found to be correlated with the divergence of Deborah number (De). During the transition of De from large to small values with accompanying morphologies, the turning point is around De = 1. The mechanism can be considered a relative humidity-dependent glass transition behavior. These unique heterogeneous structures play a key role in tuning water permeation and water sorption capacity. Insights into these aspects can prospectively contribute to a better understanding of the native heterogeneous structures for bionics design.
Low-temperature anode-free potassium metal batteries
Authors: Tang Mengyao , Dong Shuai , Wang Jiawei , Cheng Liwei , Zhu Qiaonan , Li Yanmei , Yang Xiuyi , Guo Lin , Wang Hua 
Published: September 2023

AbstractIn contrast to conventional batteries, anode-free configurations can extend cell-level energy densities closer to the theoretical limit. However, realizing alkali metal plating/stripping on a bare current collector with high reversibility is challenging, especially at low temperature, as an unstable solid-electrolyte interphase and uncontrolled dendrite growth occur more easily. Here, a low-temperature anode-free potassium (K) metal non-aqueous battery is reported. By introducing Si-O-based additives, namely polydimethylsiloxane, in a weak-solvation low-concentration electrolyte of 0.4 M potassium hexafluorophosphate in 1,2-dimethoxyethane, the in situ formed potassiophilic interface enables uniform K deposition, and offers K||Cu cells with an average K plating/stripping Coulombic efficiency of 99.80% at −40 °C. Consequently, anode-free Cu||prepotassiated 3,4,9,10-perylene-tetracarboxylicacid-dianhydride full batteries achieve stable cycling with a high specific energy of 152 Wh kg−1 based on the total mass of the negative and positive electrodes at 0.2 C (26 mA g−1) charge/discharge and −40 °C.
Metabolic inputs in the probiotic bacterium Lacticaseibacillus rhamnosus contribute to cell-wall remodeling and increased fitness
Authors: Suissa Ronit , Olender Tsviya , Malitsky Sergey , Golani Ofra , Turjeman Sondra , Koren Omry , Meijler Michael M. , Kolodkin-Gal Ilana 
Published: September 2023

AbstractLacticaseibacillus rhamnosus GG (LGG) is a Gram-positive beneficial bacterium that resides in the human intestinal tract and belongs to the family of lactic acid bacteria (LAB). This bacterium is a widely used probiotic and was suggested to provide numerous benefits for human health. However, as in most LAB strains, the molecular mechanisms that mediate the competitiveness of probiotics under different diets remain unknown. Fermentation is a fundamental process in LAB, allowing the oxidation of simple carbohydrates (e.g., glucose, mannose) for energy production under oxygen limitation, as in the human gut. Our results indicate that fermentation reshapes the metabolome, volatilome, and proteome architecture of LGG. Furthermore, fermentation alters cell envelope remodeling and peptidoglycan biosynthesis, which leads to altered cell wall thickness, aggregation properties, and cell wall composition. In addition, fermentable sugars induced the secretion of known and novel metabolites and proteins targeting the enteric pathogens Enterococcus faecalis and Salmonella enterica Serovar Typhimurium. Overall, our results link simple carbohydrates with cell wall remodeling, aggregation to host tissues, and biofilm formation in probiotic strains and connect them with the production of broad-spectrum antimicrobial effectors.
Discrepancies and error evaluation metrics for machine learning interatomic potentials
Authors: Liu Yunsheng , He Xingfeng , Mo Yifei 
Published: September 2023

AbstractMachine learning interatomic potentials (MLIPs) are a promising technique for atomic modeling. While small errors are widely reported for MLIPs, an open concern is whether MLIPs can accurately reproduce atomistic dynamics and related physical properties in molecular dynamics (MD) simulations. In this study, we examine the state-of-the-art MLIPs and uncover several discrepancies related to atom dynamics, defects, and rare events (REs), compared to ab initio methods. We find that low averaged errors by current MLIP testing are insufficient, and develop quantitative metrics that better indicate the accurate prediction of atomic dynamics by MLIPs. The MLIPs optimized by the RE-based evaluation metrics are demonstrated to have improved prediction in multiple properties. The identified errors, the evaluation metrics, and the proposed process of developing such metrics are general to MLIPs, thus providing valuable guidance for future testing and improvements of accurate and reliable MLIPs for atomistic modeling.
Modeling the effects of salt concentration on aqueous and organic electrolytes
Authors: van der Lubbe Stephanie C. C. , Canepa Pieremanuele 
Published: September 2023

AbstractUnderstanding the thermodynamic properties of electrolyte solutions is of vital importance for a myriad of physiological and technological applications. The mean activity coefficient γ± is associated with the deviation of an electrolyte solution from its ideal behavior and may be obtained by combining the Debye-Hückel (DH) and Born (B) equations. However, the DH and B equations depend on the concentration and temperature-dependent static permittivity of the solution εr(c, T) and the size of the solvated ions ri, whose experimental data is often not available. Here, we use a combination of molecular dynamics and density functional theory to predict εr(c, T) and ri, which enables us to apply the DH and B equations to any technologically relevant aqueous and nonaqueous electrolyte at any concentration and temperature of interest.