bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stakeholders and social network analysis to reduce vitamin A deficiency among children 15 - 23 months in Iran
Authors: rajaeieh golnaz , Takian Amirhossein , Bakhtiari Ahad , Nasrabadi Fatemeh Mohammadi , kalantari Naser 
Published: June 2023

Abstract
Introduction: The prevalence of vitamin A deficiency (VAD among children 15–23 months has risen from 0.5–18.3% within ten years in Iran. The success of the public health programs for controlling VAD depends on the different stakeholders' commitment, ownership, and responsibility. That is why it’s so important to identify and employ them. Method: This is a qualitative study. We conducted a content analysis of the legal documents. the stakeholders' analysis was based on the stakeholder analysis framework in the policymaker software tool and the research objectives. Gephi software version 0.9.2 was used for stakeholder network analysis and VAD risk factors. Result: 45 stakeholders are identified. 71%stakeholders are public,4.5% of stakeholders are international, 11.11%stakeholders are private, and 13% of Stakeholders are a civil society. the Ministry Of Health and Medical Education (MOHME) has the highest direct impact on this policy. 62%and38% of stakeholders are related to executive and education matters. The computed network metrics, including degree, closeness, betweenness, and eigenvector centralities, are reported. The Secretariat of the Supreme Council for Health and Food Security, UNICEF, FAO, and Deputy of public health (universities) had the highest degree value Conclusion: MOHME, is the most important stakeholder in VAD policy, in addition to legislating, they are also important through coordinating with other stakeholders. Since some powerful and influential stakeholders had a low or medium interest level to participate in policy processes, Using careful and effective strategies, ongoing negotiations, receiving advocacy, and promoting awareness among senior managers and policy-makers, can be helpful
Dopamine signals encode internal reward value rather than externally indicated attributes
Authors: Hickman Robert , Al-Mohammad Alaa , Stasiak Arkadiusz , Schultz Wolfram , Hill Daniel 
Published: June 2023

Abstract

The dopamine reward prediction error signal is known to be subjective but has so far only been related to explicit external stimuli and rewards. However, personal choices are based on private internal values of the rewards at stake. Without indications of an agent’s private internal value, we do not know whether dopamine neurons, or any reward neurons, encode the internal value. The well-established Becker-DeGroot-Marschak (BDM) auction-like mechanism allows participants to place bids for freely stating their private internal value for a good. BDM bids are known to reflect the agent’s true internal valuation, as inaccurate bidding results in suboptimal reward (‘incentive compatibility’). In our experiment rhesus monkeys placed BDM bids for juice rewards without specific external constraints. Their bids for physically identical rewards varied trial by trial and increased overall for larger rewards. Responses of midbrain dopamine neurons followed the trial-by-trial variation of bids despite constant, explicitly predicted reward amounts; correspondingly, the dopamine responses were similar when the animal placed similar bids for different reward amounts. Support Vector Regression demonstrated accurate prediction of the animal’s bids by as few as twenty dopamine neurons, demonstrating the validity of the dopamine code for internal reward value. Thus, dopamine responses reflect the instantaneous internal subjective reward value rather than the value imposed by external stimuli.
The Effect of Media Exposure on Coulrophobia Symptoms
Authors: Gan Avery YS. 
Published: June 2023

Abstract
Fear is a fundamental emotion developed by humans for evolutionary purposes. This is transmitted in human DNA through the generations to help our survival. However, people may argue that the irrational fear of clowns is standing on the opposite side of survival purposes since clowns have no hazard. Coulrophobia is relatively new as a subtype of anxiety disorder, and so less research investigates the specific reason that triggered the phobia. This study utilised the Fear of Clown Questionnaire (FCQ) to assess symptoms of coulrophobia and employed correlation analysis, independent samples t-tests, ANOVA, and regression coefficients to identify potential predictors of these symptoms. The analysis results indicated that individuals with media exposure exhibited higher scores on total items in the FCQ, indicating that their symptoms of coulrophobia differ from those of the control group. In addition, the findings revealed a significant negative correlation between exposure to the non-exposure group and coulrophobia symptoms (r=-.739, p<.001), indicating that media exposure is associated with higher symptom severity, further supporting the impact of exposure on coulrophobia symptoms.
Ecosystem Graphs: The Social Footprint of Foundation Models
Authors: Bommasani Rishi , Soylu Dilara , Liao Thomas , Creel Kathleen , Liang Percy 
Published: June 2023

Abstract
Foundation models (e.g. ChatGPT, StableDiffusion) pervasively influence society, warranting immediate social attention. While the models themselves garner much attention, to accurately characterize their impact, we must consider the broader sociotechnical ecosystem. We propose Ecosystem Graphs as a documentation framework to transparently centralize knowledge of this ecosystem. Ecosystem Graphs is composed of assets (datasets, models, applications) linked together by dependencies that indicate technical (e.g. how Bing relies on GPT-4) and social (e.g. how Microsoft relies on OpenAI) relationships. To supplement the graph structure, each asset is further enriched with fine-grained metadata (e.g. the license or training emissions). We document the ecosystem extensively at this https URL. As of March 16, 2023, we annotate 262 assets (64 datasets, 128 models, 70 applications) from 63 organizations linked by 356 dependencies. We show Ecosystem Graphs functions as a powerful abstraction and interface for achieving the minimum transparency required to address myriad use cases. Therefore, we envision Ecosystem Graphs will be a community-maintained resource that provides value to stakeholders spanning AI researchers, industry professionals, social scientists, auditors and policymakers.
Estimating real-world walking speed from a single wearable device: analytical pipeline, results and lessons learnt from the Mobilise-D technical validation study
Authors: Kirk Cameron , Kuederle Arne , Mico-Amigo M. Encarna , Bonci Tecla , Paraschiv-Ionescu Anisoara , Ullrich Martin , Soltani Abolfazl , Gazit Eran , Salis Francesca , Alcock Lisa , Aminian Kamiar , Becker Clemens , Bertuletti Stefano , Brown Philip , Buckley Ellen , Cantu Alma , Carsin Anne-Elie , Caruso Marco , Caulfield Brian , Cereatti Andrea , Chiari Lorenzo , D'Ascanio Ilaria , Garcia-Aymerich Judith , Hansen Clint , Hausdorff Jeffrey , Hiden Hugo , Hume Emily , Keogh Alison , Kluge Felix , Koch Sarah , Maetzler Walter , Megaritis Dimitrios , Mueller Arne , Niessen Martijn , Palmerini Luca , Schwickert Lars , Scott Kirsty , Sharrack Basil , Sillen Henrik , Singleton David , Vereijken Beatrix , Vogiatzis Ioannis , Yarnall Alison , Rochester Lynn , Mazza Claudia , Eskofier Bjoern , Din Silvia Del 
Published: June 2023

Abstract
Background:
Estimation of walking speed from wearable devices requires combining a set of algorithms in a single analytical pipeline. The aim of this study was to validate a pipeline for walking speed estimation and assess its performance across different factors (complexity, speed, and walking bout duration) to make recommendations on the use and validity of wearable devices for real-world mobility analysis.
Methods:
Participants with Parkinson's Disease, Multiple Sclerosis, Proximal Femoral Fracture, Chronic Obstructive Pulmonary Disease, Congestive Heart Failure, and healthy older adults (n = 97) were monitored in the laboratory and for 2.5 hours in the real-world, using a wearable device worn on the lower back. Two pipelines for estimating WS were validated across 1298 detected walking bouts, against 1365 walking bouts detected by a multi-sensor reference system.
Results:
In the laboratory, the mean absolute error (MAE) and mean absolute relative error (MARE) for estimation of walking speed ranged from − 0.06 to 0.04 m/s and 2.1–14.4% respectively, with ICCs ranged between good (0.79) and excellent (0.91). The real-world MAE ranged from − 0.04 to 0.11, and MARE from 1.3–22.7%, where ICCs showed moderate (0.57) to good (0.88) agreement. Errors were lower for cohorts with no major gait impairments, for less complex gait tasks and when considering longer walking bouts.
Conclusions:
We demonstrated that the analytical pipelines estimated walking speed with good accuracy. Accuracy was dependent upon confounding factors, highlighting the importance of undertaking a robust technical validation of wearable device-derived walking speed before clinical application.
Trial registration
ISRCTN – 12246987.
The clinical outcome, pathologic spectrum, and genomic landscape of 454 cases of salivary mucoepidermoid carcinoma
Authors: xi wang , li wei , yan jing , Li Binbin 
Published: June 2023

Abstract

Objectives To investigate the clinicopathological and molecular features of salivary mucoepidermoid carcinoma (MEC).Design The clinical features, treatment outcomes, and pathological parameters of 454 MECs were evaluated, and their genomic features were analyzed using whole-exome sequencing and whole-transcriptome sequencing.Results 414 patients were alive without relapse at follow-up, after an average period of 62 months (1–116 months). The disease progressed after initial treatment in 40 patients. The lungs were the most common site of distant metastasis. For classical MECs, histologic gradings of the AFIP, modified Healey, and MSK systems were significantly associated with recurrence and lymph nodal metastasis; these gradings were significantly related to lymph nodal metastasis for the subtypes. Older age, minor salivary gland involvement, clinical symptoms, high TNM stage, high-grade tumor, and improper surgical modality were the main prognostic factors. BAP1 was the most frequently mutated gene in MEC. Mutations in CDKN2A, MET, and TP53 were more frequently found in aggressive tumor phenotypes. MAML2 rearrangement was observed in 42% of patients, and EWSR1 rearrangement in 8%. Specific genetic events (in TP53 and FBXW7) associated with CRTC1–MAML2 fusion might cause MEC progression and might be associated with unfavorable prognosis.Conclusions A complete understanding of the high heterogeneity of MEC in histology and genetics would help in accurate diagnosis and treatment.
Inhibition of ACSS2-mediated H3K9 crotonylation alleviates kidney fibrosis via IL-1β-dependent macrophage activation and tubular cell senescence
Authors: Li Lingzhi , Xiang Ting , Wu Yiting , Feng Han , Liu Jing , Tao Sibei , Guo Fan , Fu Ping , Ma Liang 
Published: June 2023

Abstract
Histone lysine crotonylation (Kcr), a novel posttranslational modification, is widespread as acetylation (Kac); however, its roles are largely unknown. In this study, we report that histone Kcr of tubular epithelial cells was significantly elevated in fibrotic kidneys. By screening these crotonylated/acetylated factors, a crotonyl-CoA-producing enzyme—ACSS2 (acyl-CoA synthetase short chain family member 2)—was found to remarkably promote histone 3 lysine 9 crotonylation (H3K9cr) without influencing H3K9ac. Combined analysis of ChIP and RNA sequencing revealed that the hub proinflammatory cytokine, IL-1β (which is regulated by H3K9cr), may play a significant role in kidney fibrosis. Genetic and pharmacologic inhibition of ACSS2 both attenuated kidney fibrosis, as well as suppressed H3K9cr-mediated IL-1β expression, which thereby alleviated IL-1β-dependent macrophage activation and tubular cell senescence. Collectively, our findings uncover that H3K9cr plays a critical, previously unrecognized role in kidney fibrosis, where ACSS2 represents an attractive target for strategies that aim to slow fibrotic kidney disease progression.
WITHDRAWN: A cohort study on growth hormone therapy in Chinese children with Prader-Willi syndrome – the effect of treatment age
Authors: Zhou Qiong , Chao Yun-Qi , Dai Yang-Li , Shen Zheng , Dong Guan-Ping , Zou Chao-Chun 
Published: June 2023

Abstract
Background Prader-Willi syndrome (PWS) is a rare multisystemic genetic disorder. Recombinant human growth hormone (rhGH) therapy is the most established form of treatment for PWS. This study aimed to investigate the effect of rhGH treatment age on the treatment outcome of children with PWS.Methods A retrospective analysis of 167 genetically confirmed Chinese children with PWS followed between 2017 and 2022. Unadjusted and adjusted generalized estimating equations (GEE) were used to study the long-term trends in anthropometric parameters, insulin-like growth factor-1 (IGF-1), and glucose metabolism parameters during rhGH treatment in PWS. To compare the incidence of hypothyroidism, hip dysplasia, and scoliosis before and after rhGH treatment.Results The cohort had a significant increase in height/length standard deviation score (SDS). Compared to the infant group, there was an increase in height/length SDS by 0.42 (P = 0.045) and body mass index (BMI) SDS by 1.80 (P = 0.037) in the preschool group at year 3 and an increase in weight SDS by 1.09 (P = 0.037) and BMI SDS by 1.91 (P = 0.008) in the toddler group at year 3. BMI SDS remained stable in the school-age group. IGF-1 was consistently lower in the infant group than in the other groups over time (P < 0.05). Both fasting insulin (FINS) and homeostasis model assessment of insulin resistance (HOMA-IR) increased significantly in the school-age group compared to the infant group (P < 0.001). The incidence of hypothyroidism was increased in the cohort (P < 0.05), independent of treatment age (P > 0.05).Conclusions rhGH is effective in improving height/length SDS in children with PWS, especially in preschool, as well as weight and BMI-SDS in infancy and toddlerhood. rhGH appears to maintain a stable BMI-SDS in PWS long after school age. It is important to pay attention to changes in HOMA-IR during rhGH treatment. Further monitoring of high IGF-1 levels in older PWS is needed. Watch for hypothyroidism, which is often found in PWS infants, and further investigate whether it is related to long-term rhGH treatment.
Bintrafusp alfa, a bifunctional fusion protein targeting TGF-β and PD-L1, for recurrent/metastatic cervical cancer after platinum failure: primary results from a phase 2 study
Authors: Li Gui-Ling , Yunokawa Mayu , Lee Jung-Yun , Kim Byoung Gie , Oppermann Christina Pimentel , Zhou Qi , Nishio Shin , Okamoto Aikou , Wu Xiaohua , Mileshkin Linda , Oaknin Ana , Ray-Coquard Isabelle , Hasegawa Kosei , Jehl Genevieve , Vugmeyster Yulia , Zhang Sen , Bajars Marcis , Yonemori Kan , Birrer Michael 
Published: June 2023

Abstract
PURPOSE
Cervical cancer is a common and lethal cancer worldwide. Bintrafusp alfa, a first-in-class bifunctional fusion protein composed of the extracellular domain of the human transforming growth factor β receptor II (TGF-βRII or TGF-β “trap”) fused via a flexible linker to the C-terminus of each heavy chain of an immunoglobulin-G1 antibody blocking programmed death-ligand 1 (PD-L1), was evaluated in women with recurrent/metastatic cervical cancer.
PATIENT AND METHODS
This phase 2, multicenter, international, single-arm study evaluated bintrafusp alfa monotherapy in patients with recurrent/metastatic cervical cancer with disease progression during or after platinum-based chemotherapy. Patients received 1200 mg bintrafusp alfa intravenously once every 2 weeks. The primary endpoint was objective response rate (ORR) per Response Evaluation Criteria in Solid Tumors version 1.1 by Independent Review Committee (IRC). This trial was registered with clinicaltrials.gov (NCT04246489).
RESULTS
At data cutoff, 146 of 203 screened patients received ≥1 bintrafusp alfa dose. The study met its primary endpoint to have a 95% confidence interval (CI) above the ORR benchmark of 15%, with an ORR of 21.9% (95% CI 15.5-29.5) per the IRC. Of these patients, 59.4% had a durable response of ≥6 months. At data cutoff, responses were ongoing in 13/32 responders (40.6%). The most common treatment-related adverse events were anemia (17.1%), rash (14.4%), hypothyroidism (10.3%), and pruritus (10.3%). Any-cause adverse events of special interest included anemia (56.2%), bleeding events (55.5%), and immune-related adverse events.
CONCLUSION
This phase 2 study of bintrafusp alfa met its primary endpoint, which may support the potential of a bispecific therapy targeting TGF-β and PD-L1 in recurrent/metastatic cervical cancer.
Decentralized Multi-Agent Path Finding Framework and Strategies Based on Automated Negotiation
Authors: Keskin Mehmet Onur , Canturk Furkan , Eran Cihan , Aydogan Reyhan 
Published: June 2023

Abstract
This paper introduces a negotiation framework to solve Multi-Agent Path Finding (MAPF) Problem for self-interested agents in a decentralized fashion. The framework aims to achieve a good trade-off between the privacy of the agents and the effectiveness of solutions. Accordingly, a token-based bilateral negotiation protocol and two negotiation strategies are presented. The experimental results over four different settings of MAPF problem showed that the proposed approach could find conflict-free path solutions albeit suboptimally, especially when the search space is large and high-density, whereas Explicit Estimation Conflict-Based Search (EECBS) struggles to find optimal solutions. Besides, deploying a sophisticated negotiation strategy that utilizes information about local density for generating alternative paths can yield remarkably better solution performance in this negotiation framework.
Photocatalytic degradation of chlorpyrifos pesticide in aqueous solution using Cu-doped TiO2/GO photocatalysis vicinity of UV and visible light
Authors: Esfandian Hossein , Mirzaei Sogand , Chari Alireza Soltani , Ghadi Reza Abasnezhad , moqadam Iran hasan 
Published: June 2023

Abstract

In this study, the sol-gel method was used to synthesize Cu-doped TiO2/GO composite nanoparticles. The prepared samples were identified utilizing XRD, EDX-SEM, BET, and FT-IR methods. Photocatalytic absorber prepared vicinity of UV light and visible light was used to remove chlorpyrifos pesticide. The effect of factors, such as pH, amount of adsorbent, and irradiation time, on the amount of pesticide removal, was investigated. The maximum efficiency of chlorpyrifos removal was obtained at pH = 2, irradiation time of 80 minutes, and photocatalyst amount of 0.2 g for UV light and visible light, equal to 91.4% and 78.25%, respectively. The Pseudo-first order kinetics as best choice efficiency described the chlorpyrifos degradation process according to Langmuir-Hinshelwood kinetic with rate constants equal to 0.0301 and 0.0177 min− 1 vicinity of UV light and visible light respectively.
"Healing the Heart: A Retrospective Analysis of Surgical Management of Chronic Constrictive Pericarditis at Tikur Anbessa Hospital, Addis Ababa, Ethiopia
Authors: Mekonnen Wondu , Bezabih Abebe , Gullilat Dereje , kassa seyoum 
Published: June 2023

Abstract
Background: Chronic Constrictive pericarditis is a condition that can lead to diastolic heart failure due to a thickened, scarred, and non-compliant pericardium. Surgical intervention in the form of Pericardiectomy is the mainstay of treatment.
Objectives: This retrospective study aims to describe the clinical characteristics, surgical management, and outcomes of patients with Chronic constrictive pericarditis treated with Pericardiectomy at Tikur Anbessa Hospital.
Methods: Medical records of 49 patients who underwent Pericardiectomy for constrictive pericarditis at Tikur Anbessa Hospital from January 2012 to December 2016 were analyzed retrospectively. Data was collected using a well-structured questionnaire and analyzed using SPSS 20.
Results: Of the 49 patients, 34 were male (69.4%) and 15 were female (30.6%) with a mean age of 25.06 +/- 13.884 (range 6-80 years). The most common presenting symptoms were shortness of breath (98%), leg swelling (75.5%), abdominal swelling (65.3%), and cough (44.9%). 73.5% of the patients had a medical history of tuberculosis. Median sternotomy was performed in all patients, with 71.4% undergoing total Pericardiectomy and 28.6% undergoing partial Pericardiectomy. The most common intraoperative and immediate post-operative complications were low output syndrome (8.2%), myocardial perforation (6.1%), bleeding (6.1%), and wound infections (4.1%). Mortality within the same admission or within 30 days post-operative was 2%.
Conclusion: Pericardiectomy is an effective treatment for Chronic constrictive pericarditis and associated with excellent functional outcomes. Early diagnosis and surgical intervention are crucial in reducing morbidity and mortality. Tuberculosis remains an important cause of constrictive pericarditis in our setting.
Use of Dyna-computed tomography-assisted neuroendoscopic hematoma evacuation in the treatment of hypertensive intracerebral hemorrhage
Authors: Wang Heping , Tian Liang , Yang Hai , Chen Keyu 
Published: June 2023

Abstract

Objective
The purpose of this study was to evaluate and summarize the technical characteristics and clinical efficacy of using Dyna computed tomography (CT)-assisted neuroendoscopic hematoma evacuation to treat hypertensive intracerebral hemorrhage (HICH).
Patients and Methods
: We treated 42 consecutive patients with HICH who underwent neuroendoscopic hematoma evacuation in our department from March 1, 2020 to May 31, 2022. Patients were divided into two groups: Dyna-CT-assisted neuroendoscopic group (n = 18) and neuroendoscopic group (n = 24). Retrospective data, treatment efficacy, and outcomes were collected and compared between these two groups.
Results
The operative time in the Dyna-CT-assisted neuroendoscopic group was significantly shorter than the operative time in the neuroendoscopic group (mean time 131.6 ± 13.51 vs. 156.6 ± 19.25 min, P < 0.001). Dyna-CT-assisted neuroendoscopic group had significantly less intraoperative blood loss than the neuroendoscopic group. (46.94 ± 10.42 vs. 106.46 ± 23.25, P = 0.003). However, patients who underwent Dyna-CT-assisted neuroendoscopic had a comparable hematoma clearance rate to those who underwent neuroendoscopic (89.36 ± 7.31 vs. 68.87 ± 19.44%, P = 0.006). The incidence of complications in the Dyna-CT-assisted neuroendoscopic group (5.6%) was lower than in the neuroendoscopic group (12.5%), but the difference was not statistically significant (P = 0.129). Patients who underwent Dyna-CT-assisted neuroendoscopic hematoma evacuation had better 6-month functional outcomes, and the difference was significant. (p = 0.004). Furthermore, multivariable analysis showed that younger age, smaller hematoma volume and Dyna-CT-assisted neuroendoscopic were predictors of favorable 6-month outcomes in HICH patients.
Conclusion
In the treatment of HICH, Dyna-CT-assisted hematoma evacuation appears to be safer and more effective than neuroendoscopic hematoma evacuation. Dyna-CT-assisted neuroendoscopic hematoma evacuation in hybrid operating rooms may improve the clinical effect and outcomes of patients with HICH.