bluuebunny/crossref_metadata_2025_split huggingface dataset:
PAC1 Deficiency Protects Obese Male Mice From Immobilization-Induced Muscle Atrophy by Suppressing FoxO–Atrogene Axis
Authors: Li Qifang , Ishii Kiyo-aki , Kamoshita Kyoko , Takahashi Kenta , Abuduwaili Halimulati , Takayama Hiroaki , Galicia-Medina Cynthia M , Tanida Ryota , Ko Oo Hein , Gafiyatullina Guzel , Yao Xingyu , Abuduyimiti Tuerdiguli , Hamazaki Jun , Goto Hisanori , Nakano Yujiro , Takeshita Yumie , Harada Kenichi , Murata Shigeo , Takamura Toshinari 
Published: April 2023

Abstract
Muscle atrophy is the cause and consequence of obesity. Proteasome dysfunction mediates obesity-induced endoplasmic reticulum (ER) stress and insulin resistance in the liver and adipose tissues. However, obesity-associated regulation of proteasome function and its role in the skeletal muscles remains underinvestigated. Here, we established skeletal muscle-specific 20S proteasome assembly chaperone-1 (PAC1) knockout (mPAC1KO) mice. A high-fat diet (HFD) activated proteasome function by ∼8-fold in the skeletal muscles, which was reduced by 50% in mPAC1KO mice. mPAC1KO induced unfolded protein responses in the skeletal muscles, which were reduced by HFD. Although the skeletal muscle mass and functions were not different between the genotypes, genes involved in the ubiquitin proteasome complex, immune response, endoplasmic stress, and myogenesis were coordinately upregulated in the skeletal muscles of mPAC1KO mice. Therefore, we introduced an immobilization-induced muscle atrophy model in obesity by combining HFD and immobilization. mPAC1KO downregulated atrogin-1 and MuRF1, together with their upstream Foxo1 and Klf15, and protected against disused skeletal muscle mass reduction. In conclusion, obesity elevates proteasome functions in the skeletal muscles. PAC1 deficiency protects mice from immobilization-induced muscle atrophy in obesity. These findings suggest obesity-induced proteasome activation as a possible therapeutic target for immobilization-induced muscle atrophy.
The Sweetness of Race: On Synesthesia, Addiction, and Self-Possessed Personhood in Monique Truong’s Bitter in the Mouth
Authors: You Sunhay 
Published: April 2023

Abstract
“The Sweetness of Race” examines the sensorial effects of lexical-gustatory synesthesia in Monique Truong’s Bitter in the Mouth (2010). In this documentation of how words taste, whiteness becomes associated with the taste of sugar and its addictive properties. Throughout the novel, whiteness becomes legible as an object of addiction that defends against the failed ideals of self-possessed human personhood—a cornerstone to white supremacy. The novel then reveals opportunities to reorganize the senses and ideas of personhood as a means to disrupt particularly harmful appetites for racialized intimacies.
Case Report: Successful results of direct varicose vein ablation with EVLA in chronic venous insufficiency patient in Indonesia
Authors: Taofan Taofan , Utoh Junichi , Dakota Iwan , Indriani Suci , Abdillah Choiron , Kartamihardja Achmad Hafiedz Azis , Adiarto Suko , Sukmawan Renan 
Published: April 2023

Background: Varicose veins are considered a chronic venous disease. Delaying treatment might cause several late complications that contribute to a high burden on healthcare systems. It may be treated with endovenous laser ablation (EVLA) and stab avulsion as additional procedures. Varicose direct ablation has been promoted to replace stab avulsion in certain conditions. Here we report the case of a 71-year-old female who presented with chronic venous insufficiency managed by an endovascular therapeutic approach using direct varix ablation for the first time in National Cardiovascular Center – Harapan Kita, Jakarta, Indonesia. Case report: A 71-year-old female came to the outpatient clinic with a large bulging vein in her leg. Duplex ultrasound showed that the great saphenous vein (GSV) was incompetent with a varicose vein in the medial part of proximal GSV below the knee. The patient underwent EVLA with direct varicose ablation using Utoh’s technique. Duplex sonography evaluation showed the right GSV was utterly obliterated, including the varicose vein. The patient was discharged two days after the procedure without significant complaints nor pain medication. Conclusions: Direct varicose ablation was proposed as a better alternative than stab avulsion. The varicose vein can be managed with EVLA without a scalpel, incision, avulsion, or phlebectomy. In this case presentation, the endovascular therapeutical approach with Utoh’s ablation technique showed promising results, and no complication was found in the patient.
Tracking aspects of healthcare activity during the first nine months of COVID-19 in Ireland: a secondary analysis of publicly available data
Authors: McGlacken-Byrne Domhnall , Parker Sarah , Burke Sara 
Published: April 2023

Background: Sláintecare aims to introduce universal healthcare in Ireland. The COVID-19 pandemic poses both challenges and opportunities to this process. This study explored the impact of COVID-19 on aspects of Irish healthcare during the first nine months of the pandemic and considers the implications for Sláintecare implementation. Methods: Secondary analysis was undertaken on publicly available data on three key domains of the Irish healthcare system: primary care, community-based allied healthcare, and hospitals. Descriptive statistics were computed using Microsoft Excel 2016. Results: Up to March 2021, 3.76 million COVID-19 tests were performed by Ireland’s public healthcare system, 2.48 million (66.0%) of which were referred from the community. General practitioners delivered 2.31 million telephone triages of COVID-19 symptoms, peaking in December 2020 when 416,607 consultations occurred. Patient numbers across eight allied healthcare specialties fell by 35.1% versus previous years, with the greatest reductions seen in speech and language therapy (49.0%) and audiology (46.1%). Hospital waiting lists increased from 729,937 to 869,676 (or by 19.1%) from January 2019 to January 2021. In January 2021, 629,919 patients awaited a first outpatient clinic appointment, with 170,983 (27.1%) waiting longer than 18 months. The largest outpatient lists were observed in orthopaedic surgery (n=77,257); ear, nose and throat surgery (n=68,073); and ophthalmology (n=47,075). The proportion of patients waiting more than 12 months for a day-case gastrointestinal endoscopy rose from 6.0% in January 2020 to 19.0% in January 2021. Conclusions: Healthcare activity has been significantly disrupted by COVID-19, leading to increased wait times and greater barriers to healthcare access during the pandemic. Yet, Ireland’s health system responses also revealed strong willingness and ability to adapt and to implement novel solutions for healthcare delivery, rapidly and at scale. This has demonstrated what is achievable under Sláintecare and provides a unique opportunity to ‘build back better’ towards sustainable recovery.
A review of nurse independent prescribers: experiences, barriers and facilitators in palliative care
Authors: Lear Victoria 
Published: April 2023

Background: Further exploration is needed to determine whether UK-based nurse independent prescribers (NIPs) are using their advanced skills within palliative care teams, as well as whether organisations should continue to invest in developing multidisciplinary healthcare professionals in such a resource-intense skill. Aim: This study aimed to evaluate the experiences of NIPs to inform future workforce planning and service development. Methods: Practitioners' experiences were explored through a mixed-methodology online survey, which was provided to NIPs delivering end-of-life care within hospital, hospice and community settings. Findings: The survey consisted of 13 questions and was distributed to nine NIPs, six of whom responded. The barriers to prescribing were identified as a lack of confidence, time and electronic prescribing, as well as the need for increased supervision. The advantages of prescribing were described as increased pharmacological knowledge and increased and rapid symptom control for patients. Conclusions: A clear, continuous professional development pathway within the organisation is needed to support and enhance the development of NIPs. Moving forwards, electronic prescribing should be integrated to ensure safer practice.
Morpho-physiological and molecular characteristics of bacteria causing stalk rot disease on corn in Gorontalo, Indonesia
Authors: SURIANI SURIANI , PATANDJENGI BAHARUDDIN , MUIS AMRAN , JUNAID MUHAMMAD , MIRSAM HISHAR , AZRAI MUHAMMAD 
Published: April 2023

Abstract. Suriani, Patandjengi B, Muis A, Junaid M, Mirsam H, Azrai M. 2023. Morpho-physiological and molecular characteristics of bacteria causing stalk rot disease on corn in Gorontalo, Indonesia. Biodiversitas 24: 1749-1758. Stalk rot disease was observed in corn in Gorontalo with typical symptoms, such as soft rot on the stalk, leaf wilting, and plant death. This study aimed to characterize the bacteria causing stalk rot disease in corn. Samples of infected plants were collected and identified morphologically, physiologically, and molecularly. The results showed that nine bacterial isolates were isolated from infected plants. All nine isolates showed positive hypersensitive responses on tobacco leaves. In comparison, only two bacterial isolates (BGO1 and BGO4) were positive on pathogenicity tests on corn. However, the BGO4 isolate caused the highest disease incidence with a faster incubation period. The BGO4 isolate was gram-negative with white-gray colored colonies. Physiological characterization of BGO4 also showed: positive catalase and indole, oxidase negative, fermentative oxidation, caused soft rot on potato, non-fluorescent, and sensitive to erythromycin. In addition, it can grow at 37-40°C and 5% NaCl, producing protease and lecithinase enzymes. The BGO4 also isolates infected rice, corn, sorghum, foxtail millet, celery, and Aloe vera. Morpho-physiology characteristics and diagnostic amplification of DNA by PCR using the Dickeya-specific primers (ADE1/ADE2) showed that the isolate belongs to the genus Dickeya. Further molecular characterization by analysis of the 16S rDNA using universal primer 27F/1497R successfully amplified the DNA band of BGO4 isolate measuring ±1300 bp. Phylogenetic analysis showed that it was in the same group as Dickeya zeae strain MS32 from Taiwan, strain DZ15SB01 (Thailand), and strain HNJF02 (China), with the coefficient of genetic distance ranging from 0.001 to 0.002. This study is the first report of D. zeae infecting corn in Gorontalo.
Health Effects of Sleep Quality in Premutation Carrier Mothers of Individuals With Fragile X Syndrome
Authors: Dembo Robert S. , Hong Jinkuk , DaWalt Leann Smith , Berry-Kravis Elizabeth M. , Mailick Marsha R. 
Published: April 2023

Abstract
Sleep plays an integral role in supporting well-being, and sleep difficulties are common in mothers of individuals with developmental disabilities, including fragile X syndrome (FXS). This study assessed whether the effects of sleep quality on physical health and depression are exacerbated by genetic risk factors (CGG repeats) in FMR1 premutation carrier mothers of individuals with FXS. Poor sleep quality predicted a greater number of physical health conditions for mothers with CGG repeats in the mid-premutation range (90–110 repeats), but not for those in the lower (&lt; 90 repeats) or higher (&gt; 110 repeats) ends of the range. A significant association between poor sleep quality and maternal depressive symptoms was also observed, but there was no evidence that this effect varied by level of genetic vulnerability. This research extends our understanding of individual differences in the effects of sleep quality among mothers of individuals with FXS.
Enhanced chirality induced in a composite structure consisting of α-MoO3 film and a silver metasurface
Authors: Yang Bing , Huang Yueli , Wu Biyuan , Ma Zenghong , Zhou Kun , Wu Xiaohu 
Published: April 2023

Chiral structures have been widely used in many fields, such as biosensing and analytical chemistry. In this paper, the chiral response of a composite structure consisting of α-MoO3 film and a silver (Ag) metasurface is studied. First, the effect of the thickness of α-MoO3 film on the circular dichroism (CD) is discussed, and it is found that CD can reach 0.93 at a wavelength of 9.6 µm when the thickness of α-MoO3 film is 6.075 µm. To better understand the physical mechanism, we analyze the transverse electric and transverse magnetic wave components in the transmitted wave for the whole structure and each layer. One can see that the strong chirality of the structure is attributed to the polarization conversion of α-MoO3 film and the selective transmissivity of Ag ribbons. In addition, the influence of the filling factor of the Ag ribbons on chirality is also studied. This work combines hyperbolic material α-MoO3 with Ag ribbons to enhance CD. Also, it provides greater freedom in the tuning of chirality. We believe that this work not only deepens the understanding of the chiral response of anisotropic materials, but also gives promise for its applications in the fields of polarization optics and biosensing.
Real world effectiveness of tixagevimab/cilgavimab (Evusheld) in the Omicron era
Authors: Chen Benjamin , Haste Nina , Binkin Nancy , Law Nancy , Horton Lucy E. , Yam Nancy , Chen Victor , Abeles Shira 
Published: April 2023

Background
Pre-exposure prophylaxis for COVID-19 with tixagevimab/cilgavimab (T/C) received Emergency Use Authorization (EUA) based on results of a clinical trial conducted prior to the emergence of the Omicron variant. The clinical effectiveness of T/C has not been well described in the Omicron era. We examined the incidence of symptomatic illness and hospitalizations among T/C recipients when Omicron accounted for virtually all local cases.

Methods
Through retrospective electronic medical record chart review, we identified patients who received T/C between January 1 –July 31, 2022 within our quaternary referral health system. We determined the incidence of symptomatic COVID-19 infections and hospitalizations due to or presumed to be caused by early Omicron variants before and after receiving T/C (pre-T/C and post-T/C). Chi square and Mann-Whitney Wilcoxon two-sample tests were used to examine differences between the characteristics of those who got COVID-19 before or after T/C prophylaxis, and rate ratios (RR) and 95% confidence intervals (CI) were calculated to assess differences in hospitalization rates for the two groups.

Results
Of 1295 T/C recipients, 105 (8.1%) developed symptomatic COVID-19 infection before receiving T/C, and 102 (7.9%) developed symptomatic disease after receiving it. Of the 105 patients who developed symptomatic infection pre-T/C, 26 (24.8%) were hospitalized, compared with six of the 102 patients (5.9%) who were diagnosed with COVID-19 post-T/C (RR = 0.24; 95% CI = 0.10–0.55; p = 0.0002). Seven of the 105 (6.7%) patients infected pre-T/C, but none of the 102 infected post-T/C required ICU care. No COVID-related deaths occurred in either group. The majority of COVID-19 cases among those infected pre-T/C treatment occurred during the Omicron BA.1 surge, while the majority of post-T/C cases occurred when Omicron BA.5 was predominant. In both groups, having at least one dose of vaccine strongly protected against hospitalization (pre-T/C group RR = 0.31, 95% CI = 0.17–0.57, p = 0.02; post-T/C group RR = 0.15; 95% CI = 0.03–0.94; p = 0.04).

Conclusion
We identified COVID-19 infections after T/C prophylaxis. Among patients who received T/C at our institution, COVID-19 Omicron cases occurring after T/C were one-fourth as likely to require hospitalization compared to those with Omicron prior to T/C. However, due to the presence of changing vaccine coverage, multiple therapies, and changing variants, the effectiveness of T/C in the Omicron era remains difficult to assess.
Understanding COVID-19 vaccine hesitancy in Malaysia: Public perception, knowledge, and acceptance
Authors: Mohamed Nurul Azmawati , Solehan Hana Maizuliana , Mohd Rani Mohd Dzulkhairi , Ithnin Muslimah , Arujanan Mahalecthumy 
Published: April 2023

Background
Vaccine hesitancy has been around since the introduction of smallpox vaccine. Vaccine hesitancy has become more intense due to the rise of vaccine information in social media and mass adult vaccination during COVID-19 pandemic. This study investigated knowledge, perception, and reasons for rejection of the COVID-19 vaccine among Malaysian adults who refused to get free COVID-19 vaccination.

Methods
An online cross-sectional survey using an embedded mixed-method study [QUAN(quali)] was conducted among Malaysian adults. The quantitative section consisted of a 49-item questionnaire, whereas the qualitative sections consisted of two open-ended questions (1) "Please state your reason why you have not registered or have no intention to register at all for COVID-19 vaccines?" and (2) "Please tell us if you have any suggestions for improvement about COVID-19 vaccine delivery". Data from respondents who were not willing to get vaccination were extracted from the overall data and further analyzed in this paper.

Result
Sixty-one adults completed the online open-ended survey with a mean age of 34.28 years (SD = 10.30). Among factors that influenced them to get vaccinated was information on vaccine effectiveness (39.3%), death due to COVID-19 (37.7%), and recommendations from the Ministry of Health (36.1%). Most of the respondents (77.0%) were knowledgeable about vaccines, with half having high-perceived risks (52.5%) to COVID-19. While 55.7% and 52.5% had, high perceived barriers and benefits to COVID-19 vaccines respectively. The reasons for vaccine rejections included vaccine safety, indecisiveness, underlying medical conditions, herd immunity, non-transparent data, and use of traditional or complementary medicine.

Conclusion
The study explored the multitude factors that drive perception, acceptance, and rejection. The qualitative approach with a small sample size provided more data point for interpretations and allowed participants to express themselves. This is important to develop strategies to create public awareness on vaccines not just for COVID-19 but any infectious diseases that can be curbed through vaccination.
Public sentiment analysis on urban regeneration: A massive data study based on sentiment knowledge enhanced pre-training and latent Dirichlet allocation
Authors: Chen Kehao , Wei Guiyu 
Published: April 2023

Background
Public satisfaction is the ultimate goal and an important determinant of China’s urban regeneration plan. This study is the first to use massive data to perform sentiment analysis of public comments on China’s urban regeneration.

Methods
Public comments from social media, online forums, and government affairs platforms are analyzed by a combination of Natural Language Processing, Knowledge Enhanced Pre-Training, Word Cloud, and Latent Dirichlet Allocation.

Results
(1) Public sentiment tendency toward China’s urban regeneration was generally positive but spatiotemporal divergences were observed; (2) Temporally, public sentiment was most negative in 2020, but most positive in 2021. It has remained consistently negative in 2022, particularly after February 2022; (3) Spatially, at the provincial level, Guangdong posted the most comments and Tibet, Shanghai, Guizhou, Chongqing, and Hong Kong are provinces with highly positive sentiment. At the national level, the east and south coastal, southwestern, and western China regions are more positive, as opposed to the northeast, central, and northwest regions; (4) Topics related to Shenzhen’s renovations, development of China’s urban regeneration and complaints from residents are validly categorized and become the public’s key focus. Accordingly, governments should address spatiotemporal disparities and concerns of local residents for future development of urban regeneration.
Lovemarks and beyond: Examining the link between lovemarks and brand loyalty through customer advocacy in the automobile industry
Authors: Javed Nayab , Khalil Syed Haider , Ishaque Amir , Khalil Syed Majid 
Published: April 2023

PurposeDespite the potential for businesses, our understanding of lovemark brands and their consequences is limited. Numerous psychological and brand-related consequences are linked to lovemarks, but the role of influential underlining mechanisms is not fully understood. Inspired by the norms of reciprocity theory, the current study investigates the underlining role of customer advocacy in the relationship between perceived lovemarks and brand loyalty of customers in the automobile industry.MethodologyBy adopting the survey method, a sample of 478 was drawn from Pakistani automobile customers. Structural equation modelling was used for the analysis. We conceptualised lovemarks and brand loyalty as reflective higher-order constructs that we analysed through a two-stage disjoint analysis.FindingsOur results support the conceptualization of lovemarks and brand loyalty as higher-order constructs. The influence of lovemarks and customer advocacy on brand loyalty was statistically significant when we controlled for age, gender, and income. Our findings also reveal that customer advocacy, seen as a company’s positive interactions, mediates and play a key role in influencing the relationship between lovemarks and brand loyalty.OriginalityThis is among the first studies to examine the role of customer advocacy in the lovemarks-brand loyalty relationship. We examined these relationships in the automobile sector of Pakistan, which offers several theoretical and managerial implications for academia and practitioners. The implications are proposed and outlined in this study.
Influência de um condensador externo no dessalinizador solar do tipo bandeja para obter água dessalinizada no município de Queimadas
Authors: Viana Wanderley , Rocha Genilma Maria Gonçalves da , Lima Carlos Antônio Pereira de , Medeiros Keila Machado de 
Published: April 2023

O dessalinizador solar de dupla inclinação do tipo bandeja foi utilizado com o intuito de obter uma água tratada. Este trabalho teve como objetivo avaliar o desempenho da produção de água dessalinizada do dessalinizador solar com um condensador externo e as características físico-química da água antes e após o processo de dessalinização. Um poço de água salobra do Sítio Alto dos Cordeiros do município de Queimadas – PB foi utilizada como fonte de água a ser tratada. O dessalinizador solar tem uma área de 4 m² em que o dessalinizador solar de controle denominado como (D1) e o dessalinizador solar como o condensador externo denominado de (D2+C) e a água salina utilizada no experimento tem condutividade elétrica de 1820 µS.cm-1 e pH de 7,3. Os resultados observado mais significativos foram a produção máxima de água potável no dia 19 de novembro de 2022, onde obteve um valor de 8,6 L.dia-1 para o dessalinizador solar com o condensador externo (D2+C) sendo que o dessalinizador solar (D2) produziu 7,61 L.dia-1 e o condensador externo 0,99 L.dia-1 para o dessalinizador solar de controle (D1) teve uma produção de 8,58 L.dia-1 e um índice de radiação solar média para os dois dessalinizadores solar de 874,8 W.m-2 em uma lâmina de água salina com profundidade de 1cm. Os resultados obtidos das análises físico-químicas das águas salobra e dessalinizada apresentaram reduções na condutividade elétrica de 99,07 % para (D1) com pH de 7,3 e 99,56 % para (D2+C) com pH de 7,3 para o dia 19 e para o dia 22 de novembro, obteve uma redução de 99,45% para (D1) com pH de 6,03 e 99,4% para (D2+C) com pH de 6,4 após o processo de dessalinização, atingindo valores de acordo com os padrões de potabilidade exigidos pela Portaria do Ministério da Saúde vigente no país.