bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Benefits of Dog-Assisted Therapy for Children With Anxiety
Authors: Wu Andrea , Wei Ruth 
Published: August 2023

Background Anxiety disorders are one of the most common mental health disorders experienced by children, and they have a negative effect on social, academic, and health functioning. While traditional psychotherapy has focused on methods such as cognitive behavioural therapy and parental anxiety management to treat these children, interest is growing in animal-assisted therapy (AAT) as a therapeutic modality, and recent research suggests the benefits of AAT within the realms of psychotherapy for children with anxiety. Aim This review aimed to perform a critical appraisal of the available literature relating to dog-assisted psychotherapy for children with anxiety and investigate the effectiveness of this therapy method in reducing anxiety. Method This structured literature review was guided by the 12 steps recommended by Kable et al. (2012). The search was conducted in August and September 2021 through the databases ScienceDirect, PsycInfo, and PubMed to locate published peer-reviewed literature on the therapeutic benefits of including a dog in psychotherapy sessions for children with anxiety. After critical appraisal, 10 articles were included in the review. Results General agreement exists that dog-assisted therapy can boost positive emotions and reduce anxiety levels in children, and that interacting with dogs and experiencing their unconditional acceptance help reduce children’s stress and physical pain levels as well as stress in families. The key themes that emerged from this review included the human–animal bond, children’s attachment styles, hospitalisation and environmental considerations, the AAT methods used, and the effects of AAT. Conclusion This review revealed many benefits of the presence of a therapy dog during psychotherapy sessions, including reducing anxiety, increasing positive emotions, and enabling social interactions for children with anxiety. Counsellors and psychotherapists can feel confident to undertake the required training and implement the necessary systems to accommodate a therapy dog in their therapeutic setting in order to support children with anxiety. It is noteworthy that the positive effects of dog-assisted therapy were not consistent throughout the literature, and most research studies focused on children in hospital settings. Therefore, further research is required regarding the effectiveness and clinical implications of the nature, type of intervention, length, and duration of dog-assisted therapy.
Nationwide mammography screening participation in Denmark during the COVID-19 pandemic: An observational study
Authors: Olesen Tina Bech , Jensen Henry , Møller Henrik , Jensen Jens Winther , Andersen Berit , Vejborg Ilse , Njor Sisse H 
Published: August 2023

Background:In most of the world, the mammography screening programmes were paused at the start of the pandemic, whilst mammography screening continued in Denmark. We examined the mammography screening participation during the COVID-19 pandemic in Denmark.Methods:The study population comprised all women aged 50–69 years old invited to participate in mammography screening from 2016 to 2021 in Denmark based on data from the Danish Quality Database for Mammography Screening in combination with population-based registries. Using a generalised linear model, we estimated prevalence ratios (PRs) and 95% confidence intervals (CIs) of mammography screening participation within 90, 180, and 365 d since invitation during the pandemic in comparison with the previous years adjusting for age, year and month of invitation.Results:The study comprised 1,828,791 invitations among 847,766 women. Before the pandemic, 80.2% of invitations resulted in participation in mammography screening within 90 d, 82.7% within 180 d, and 83.1% within 365 d. At the start of the pandemic, the participation in screening within 90 d was reduced to 69.9% for those invited in pre-lockdown and to 76.5% for those invited in first lockdown. Extending the length of follow-up time to 365 d only a minor overall reduction was observed (PR = 0.94; 95% CI: 0.93–0.95 in pre-lockdown and PR = 0.97; 95% CI: 0.96–0.97 in first lockdown). A lower participation was, however, seen among immigrants and among women with a low income.Conclusions:The short-term participation in mammography screening was reduced at the start of the pandemic, whilst only a minor reduction in the overall participation was observed with longer follow-up time, indicating that women postponed screening. Some groups of women, nonetheless, had a lower participation, indicating that the social inequity in screening participation was exacerbated during the pandemic.Funding:The study was funded by the Danish Cancer Society Scientific Committee (grant number R321-A17417) and the Danish regions.
Fruit‐Derived Extracellular‐Vesicle‐Engineered Structural Droplet Drugs for Enhanced Glioblastoma Chemotherapy
Authors: Chen Jianping , Pan Jiahao , Liu Sijia , Zhang Yangning , Sha Suinan , Guo Haoyan , Wang Xuejiao , Hao Xiangrong , Zhou Houwang , Tao Sijian , Wang Ying , Fan Jun‐Bing 
Published: August 2023

AbstractExisting solid‐nanoparticle‐based drug delivery systems remain a great challenge for glioblastoma chemotherapy due to their poor capacities in crossing the blood–brain barrier/blood–brain tumor barrier (BBB/BBTB). Herein, fruit‐derived extracellular‐vesicle (EV)‐engineered structural droplet drugs (ESDDs) are demonstrated by programming the self‐assembly of fruit‐derived EVs at the DOX@squalene–PBS interface, greatly enhancing the antitumor efficacy against glioblastoma. The ESDDs experience a flexible delivery via deformation‐amplified macropinocytosis and membrane fusion, enabling them to highly efficiently cross the BBB/BBTB and deeply penetrate glioblastoma tissues. As expected, the ESDDs exhibit approximately 2.5‐fold intracellular uptake, 2.2‐fold transcytosis, and fivefold membrane fusion higher than cRGD‐modified EVs (REs), allowing highly efficient accumulation, deep penetration, and cellular internalization into the glioblastoma tissues, and thereby significantly extending the survival time of glioblastoma mice.
High‐Rate Lithium–Selenium Batteries Boosted by a Multifunctional Janus Separator Over a Wide Temperature Range of −30 °C to 60 °C
Authors: Guo Yue , Zhu Shengqing , Mao Chenghui , Chen Yiqun , Liu Liwei , Liu Jiaheng , Wang Xizhang , Wu Qiang , Yang Lijun , Hu Zheng 
Published: August 2023

AbstractLithium–selenium batteries are characterized by high volumetric capacity comparable to Li–S batteries, while ≈1025 times higher electrical conductivity of Se than S is favorable for high‐rate capability. However, they also suffer from the “shuttling effect” of lithium polyselenides (LPSes) and Li dendrite growth. Herein, a multifunctional Janus separator is designed by coating hierarchical nitrogen‐doped carbon nanocages (hNCNC) and AlN nanowires on two sides of commercial polypropylene (PP) separator to overcome these hindrances. At room temperature, the Li–Se batteries with the Janus separator exhibit an unprecedented high‐rate capability (331 mAh g−1 at 25 C) and retain a high capacity of 408 mAh g−1 at 3 C after 500 cycles. Moreover, the high retained capacities are achieved over a wide temperature range from −30 °C to 60 °C, showing the potential application under extreme environments. The excellent performances result from the “1+1>2” synergism of suppressed LPSes shuttling by chemisorption and electrocatalysis of hNCNC on the cathode side and suppressed Li‐dendrite growth by thermally conductive AlN‐network on the anode side, which can be well understood by the “Bucket Effect”. This Janus separator provides a general strategy to develop high‐performance lithium–chalcogen (Se, S, SeS2) batteries.
Nickel/Copper Co‐catalyzed Enantioselective Reductive Coupling of Oxabenzonorbornadienes with Vinyl Bromides
Authors: Deng Yao , Meng Yunyan , Yang Qiongtong , Liu Zixiu , Fan Ruifeng , Chen Jingchao , Fan Baomin 
Published: August 2023

AbstractThe enantioselective reductive coupling of oxabenzonorbornadiene with vinyl bromide is developed with earth‐abundant nickel catalyst with copper as Lewis acid co‐catalyst. The asymmetric reductive coupling is applicable with a wide range of azabenzonorbornadienes and vinyl bromides under nickel/copper co‐catalytic system, affording the cis ring‐opening vinylation products in good yields with high optical purities. The present study has enabled straightforward stereoselective preparation of chiral 2‐vinyl‐tetrahydronaphthalens from vinyl halides.
Sodium Bicarbonate Nanoparticles for Amplified Cancer Immunotherapy by Inducing Pyroptosis and Regulating Lactic Acid Metabolism
Authors: Ding Binbin , Zheng Pan , Tan Jia , Chen Hao , Meng Qi , Li Jing , Li Xinyang , Han Di , Li Ziyao , Ma Xinyu , Ma Ping'an , Lin Jun 
Published: August 2023

AbstractAlthough immunotherapy has a broad clinical application prospect, it is still hindered by low immune responses and immunosuppressive tumor microenvironment. Herein, a simple and drug‐free inorganic nanomaterial, alkalescent sodium bicarbonate nanoparticles (NaHCO3 NPs), is prepared via a fast microemulsion method for amplified cancer immunotherapy. The obtained alkalescent NaHCO3 regulates lactic acid metabolism through acid‐base neutralization so as to reverse the mildly acidic immunosuppressive tumor environment. Additionally, it can further release high amounts of Na+ ions inside tumor cells and induce a surge in intracellular osmolarity, and thus activate the pyroptosis pathway and immunogenic cell death (ICD), release damage‐associated molecular patterns (DAMPs) and inflammatory factors, and improve immune responses. Collectively, NaHCO3 NPs observably inhibit primary/distal tumor growth and tumor metastasis through acid neutralization remitted immunosuppression and pyroptosis induced immune activation, showing an enhanced antitumor immunity efficiency. This work provides a new paradigm for lactic acid metabolism and pyroptosis mediated tumor treatment, which has a potential for application in clinical tumor immunotherapy.
Constructing Photoactivatable Protein with Genetically Encoded Photocaged Glutamic Acid
Authors: Yang Xiaochen , Zhao Lei , Wang Ying , Ji Yanli , Su Xun‐Cheng , Ma Jun‐An , Xuan Weimin 
Published: August 2023

AbstractGenetically replacing an essential residue with the corresponding photocaged analogues via genetic code expansion (GCE) constitutes a useful and unique strategy to directly and effectively generate photoactivatable proteins. However, the application of this strategy is severely hampered by the limited number of encoded photocaged proteinogenic amino acids. Herein, we report the genetic incorporation of photocaged glutamic acid analogues in E. coli and mammalian cells and demonstrate their use in constructing photoactivatable variants of various fluorescent proteins and SpyCatcher. We believe genetically encoded photocaged Glu would significantly promote the design and application of photoactivatable proteins in many areas.
Analysis of Quinolinequinone Analogs with Promising Cytotoxic Activity against Breast Cancer
Authors: Yilmaz Goler Ayse Mine , Tarbin Jannuzzi Ayse , Biswas Abanish , Mondal Subodh , Basavanakatti Vinay N. , Jayaprakash Venkatesan Raghusrinivasan , Yıldırım Hatice , Yıldız Mahmut , Çelik Onar Hülya , Bayrak Nilüfer , Jayaprakash Venkatesan , TuYuN Amaç Fatih 
Published: August 2023

AbstractIt is quite challenging to find out bioactive molecules in the vast chemical universe. Quinone moiety is a unique structure with a variety of biological properties, particularly in the treatment of cancer. In an effort to develop potent and secure antiproliferative lead compounds, five quinolinequinones (AQQ1‐5) described previously have been selected and submitted to the National Cancer Institute (NCI) of Bethesda to envisage their antiproliferative profile based on the NCI Developmental Therapeutics Program. According to the preliminary in vitro single‐dose anticancer screening, four of five quinolinequinones (AQQ2‐5) were selected for five‐dose screening and they displayed promising antiproliferative effects against several cancer types. All AQQs showed a excellent anticancer profile with low micromolar GI50 and TGI values against all leukemia cell lines, some non‐small cell lung and ovarian cancer, most colon, melanoma, and renal cancer, and in addition to some breast cancer cell lines. AQQ2‐5 reduced the proliferation of all leukemia cell lines at a single dose and five additional doses, as well as some non‐small cell lung and ovarian cancer, the majority of colon cancer, melanoma and renal cancer, and some breast cancer cell lines. This motivated us to use in vitro, in silico, and in vivo technologies to further investigate their mode of action. We investigated the in vitro cytotoxic activities of the most promising compounds, AQQ2 and AQQ3, in HCT‐116 colon cancer, MCF7 and T‐47D breast cancer, and DU‐145 prostate cancer cell lines, and HaCaT human keratinocytes. Concomitantly, IC50 values of AQQ2 and AAQ3 against MCF7 and T‐47D cell lines of breast cancer, DU‐145 cell lines of prostate cancer, HCT‐116 cell lines of colon cancer, and HaCaT human keratinocytes were determined. AQQ2 exhibited anticancer activity through the induction of apoptosis and caused alterations in the cell cycle. In silico pharmacokinetic studies of all analogs have been carried out against ATR, CHK1, WEE1, CDK1, and CDK2. In addition to this, in vitro ADME and in vivo pharmacokinetic profiling for the most effective AAQ (AAQ2) have been studied.
Effect of packaging materials on the bioactive compounds, antioxidant activity, and shelf life of germinated brown rice during storage
Authors: Jabeen Rifat , Hussain Syed Zameer , Jan Nusrat , Malik Ajaz , Raja Tariq A. 
Published: August 2023

AbstractBackground and ObjectivesGerminated brown rice (GBR) has been proposed as a strategy to alleviate chronic disorders by delivering nutrients and biologically active substances; therefore, appropriate packaging materials and storage are necessary to preserve these bioactive phytochemicals. In this research, we investigated the bioactive compounds, antioxidant activities, and microbial load of GBR and ungerminated brown rice stored in low‐density polyethylene (LDPE) and linear low‐density polyethylene (LLDPE) pouches for a period of 9 months.FindingsThe storage of GBR samples packed in LDPE and LLDPE was evaluated in terms of changes in the moisture content (MC), water activity (aw), color (L* value), bioactive components, antioxidant activities, and microbial growth. The MC, aw, and L* values of GBR increased with prolonged storage, with a slower increase observed in samples packed in LLDPE (from 9.47% to 10.94%, from 0.394% to 0.507%, and from 59.24% to 70.68%, respectively). The bioactive components, including γ‐aminobutyric acid (GABA), γ‐oryzanol, niacin, and total phenolic contents, decreased in both packaging materials, but the decrease was minimum in samples packed in LLDPE (from 48.18 to 37.72 mg/100 g, from 72.73 to 63.92 mg/100 g, from 4.14% to 3.67%, and from 87.60% to 78.69%, respectively). The antioxidant activities of GBR were preserved when packed in LLDPE pouches stored under ambient conditions. 1,1‐Diphenyl‐2‐picrylhydrazyl increased from 83.11 to 71.85 μmol TE/100 g and ferric‐reducing antioxidant power decreased from 16.28 to 10.67 μmol trolox equivalents (TE)/100 g, respectively, in GBR samples packed in LLDPE. The increase in free fatty acids and the total plate count was more rapid in samples packed in LDPE (0.24–0.46 mg KOH/100 g and 0.00–1.04 colony‐forming unit (CFU)/g, respectively), whereas the increase was effectively delayed in samples packed in LLDPE (0.24–0.37 mg KOH/100 g and 0.00–0.71 CFU/g, respectively).ConclusionIn the present study, it is concluded that the use of LLDPE as a packaging material for GBR could significantly retain its biologically active components and delay the deterioration of its quality during storage.Significance and NoveltyProper storage is crucial for maintaining the quality of rice from harvest to consumption, and the use of LDPE and LLDPE pouches as packaging materials for GBR presents a novel approach that has not been extensively explored. The results of the current study demonstrate that storage of GBR in LLDPE pouches proved to be a highly effective method for preserving the valuable biologically active components, highlighting the potential of this packaging material for extending the shelf life and maintaining the nutritional value of GBR.
Rational Design, Multistep Synthesis and in Vitro Evaluation of Poly(glycerol) Functionalized Nanodiamond Conjugated with Boron‐10 Cluster and Active Targeting Moiety for Boron Neutron Capture Therapy
Authors: Nishikawa Masahiro , Yu Jie , Kang Heon Gyu , Suzuki Minoru , Komatsu Naoki 
Published: August 2023

AbstractBoron neutron capture therapy (BNCT), advanced cancer treatment utilizing nuclear fission of 10B atom in cancer cells, is attracting increasing attention. As 10B delivery agent, sodium borocaptate (10BSH, 10B12H11SH ⋅ 2Na), has been used in clinical studies along with L‐boronophenylalanine. Recently, this boron cluster has been conjugated with lipids, polymers or nanoparticles to increase selectivity to and retentivity in tumor. In this work, anticancer nanoformulations for BNCT are designed, consisting of poly(glycerol) functionalized detonation nanodiamonds (DND−PG) as a hydrophilic nanocarrier, the boron cluster moiety (10B12H112−) as a dense boron‐10 source, and phenylboronic acid or RGD peptide as an active targeting moiety. Some hydroxy groups in PG were oxidized to carboxy groups (DND−PG−COOH) to conjugate the active targeting moiety. Some hydroxy groups in DND−PG−COOH were then transformed to azide to conjugate 10B12H112− through click chemistry. The nanodrugs were evaluated in vitro using B16 murine melanoma cells in terms of cell viability, BNCT efficacy and cellular uptake. As a result, the 10B12H112− moiety is found to facilitate cellular uptake probably due to its negative charge. Upon thermal neutron irradiation, the nanodrugs with 10B12H112− moiety exhibited good anticancer efficacies with slight differences with and without targeting moiety.
Absolute and Relative Bioavailability of Oral Solid Dosage Formulations of Deucravacitinib in Humans
Authors: Chimalakonda Anjaneya , Li Wenying , Marchisin David , He Bing , Singhal Shalabh , Deshpande Prashant , Brown Jonathan , Aras Urvi , Murthy Bindu 
Published: August 2023

AbstractDeucravacitinib is an oral, selective, allosteric inhibitor of tyrosine kinase 2, an intracellular signaling kinase involved in the pathogenesis of immune‐mediated inflammatory diseases. The absolute and relative bioavailability (BA) were evaluated in phase 1, open‐label studies in healthy adults to assess (1) the absolute BA of the deucravacitinib tablet formulation following single oral administration of a 12‐mg tablet and an intravenous microdose infusion of 0.1‐mg carbon‐13 and nitrogen‐15–labeled deucravacitinib ([13C2, 15N3] deucravacitinib) solution in 8 subjects, and (2) the relative oral BA of deucravacitinib tablet and capsule formulations at the 3‐ and 12‐mg dose levels in 20 subjects. The absolute oral availability of deucravacitinib in the tablet formulation was near complete at approximately 99%. The total clearance (254 mL/min) was low relative to hepatic blood flow, and volume of distribution (∼140 L) was greater than total body water, indicating extravascular distribution. Deucravacitinib systemic exposure (maximum plasma concentration, area under the plasma drug concentration curve from time zero to the time of the last quantifiable nonzero concentration, and area under the plasma drug concentration–time curve from time zero extrapolated to infinity) after administration of the tablet formulation were similar to the capsule at the tested 3‐ and 12‐mg doses. In both studies, deucravacitinib was safe with no clinically relevant changes in laboratory values, electrocardiogram parameters, or vital signs.
One‐Pot Chitin Conversion to High‐Activity Antifungal N,N‐Dimethyl Chitosan Oligosaccharides
Authors: Cheng Jiong , Armugam Arunmozhiarasi , Zhang Yugen , Yang Yang , Jin Fangming , Yan Ning 
Published: August 2023

AbstractInvited for this month′s cover is the group of Ning Yan at the National University of Singapore. The image shows the production of modified oligosaccharides from marine biomass as powerful antimicrobial ‘weapon’ through the ‘booster’ made of formaldehyde. The Research Article itself is available at 10.1002/cssc.202300591.
Transitions in Solvate Crystals of a Tetraaryladamantane
Authors: Frey Wolfgang , Schwenger Alexander , Berking Tim , Richert Clemens 
Published: August 2023

AbstractObtaining high‐resolution structures of liquid compounds can be difficult. Encapsulating them in the lattice of a larger organic molecule acting as crystallization chaperone is one option to overcome this difficulty. Tetraaryladamantane ethers can play the role of chaperones, accommodating a range of different guest molecules in their crystals. How well‐ordered crystalline arrangements for molecules of different shape are achieved is not clear. Cases in which more than one structure is found may shed light on this phenomenon. Here, we report low‐order cubic crystal structures of 1,3,5,7‐tetrakis(2,4‐dimethoxyphenyl)adamantane (TDA) encapsulating ortho‐xylene or cyclohexane, together with better ordered structures obtained after warming the crystals to 60 °C. Evidence for cubic crystal systems was also found for limonene, hexachlorobutadiene and eucalyptol, with a transition to a triclinic system for the former two, but no transition up to 70 °C for the latter. These findings indicate that some solvate structures of TDA can readily undergo structural transitions to less solvated, better ordered systems. Crystals obtained by rapid thermal crystallization may be in kinetically trapped states, and the transition to a solvate‐free crystal system appears to have a kinetic barrier that depends strongly on the structure of the liquid guest molecules encapsulated in the lattice.