bluuebunny/crossref_metadata_2025_split huggingface dataset:
The combination of non-contrast abbreviated MRI and alpha foetoprotein has high performance for hepatocellular carcinoma screening
Authors: Girardet Raphaël , Dubois Margaux , Manasseh Gibran , Jreige Mario , Du Pasquier Céline , Canniff Emma , Gulizia Marianna , Bonvin Melissa , Aleman Yasser , Taouli Bachir , Fraga Montserrat , Dromain Clarisse , Vietti Violi Naik 
Published: July 2023

Abstract
Objectives
This study aimed to compare two abbreviated MRI (AMRI) protocols to complete MRI for HCC detection: non-contrast (NC)-AMRI without/with alpha foetoprotein (AFP) and dynamic contrast-enhanced (Dyn)-AMRI.

Methods
This retrospective single-center study included 351 patients (M/F: 264/87, mean age: 57y) with chronic liver disease, who underwent MRI for HCC surveillance between 2014 and 2020. Two reconstructed AMRI sets were obtained based on complete MRI: NC-AMRI (T2-weighted imaging (WI) + diffusion-WI) and Dyn-AMRI (T2-WI + dynamic T1-WI) and were assessed by 2 radiologists who reported all suspicious lesions, using LI-RADS/adapted LI-RADS classification. The reference standard was based on all available patient data. Inter-reader agreement was assessed and MRI diagnostic performance was compared to the reference standard.

Results
The reference standard demonstrated 83/351 HCC-positive patients (prevalence: 23.6%, median size: 22 mm, and positive MRIs: 83/631). Inter-reader agreement was substantial for all sets. Sensitivities of Dyn-AMRI and complete MRI (both 92.8%) were similar, higher than NC-AMRI (72.3%, p < 0.001). Specificities were not different between sets. NC-AMRI + AFP (92.8%) had similar sensitivity to Dyn-AMRI and complete MRI. In patients with small size HCCs (≤ 2 cm), sensitivities of Dyn-AMRI (85.3%) and complete MRI (88.2%) remained similar (p = 0.564), also outperforming NC-AMRI (52.9%, p < 0.05). NC-AMRI + AFP had similar sensitivity (88.2%) to Dyn-AMRI and complete MRI (p = 0.706 and p = 1, respectively).

Conclusions
Dyn-AMRI has similar diagnostic performance to complete MRI for HCC detection, while both outperform NC-AMRI, especially for small size HCCs. NC-AMRI + AFP demonstrates similar sensitivity to Dyn-AMRI and complete MRI.

Clinical relevance statement
Due to the low sensitivity of ultrasound for hepatocellular screening, new screening methods are needed. Abbreviated MRI (AMRI) is a candidate, especially non-contrast AMRI with serum alpha foetoprotein as the acquisition time is low, without the need for contrast medium injection.

Key Points
• Dynamic contrast-enhanced abbreviated MRI using extracellular gadolinium-based contrast agent and complete MRI have similar diagnostic performance for hepatocellular carcinoma detection in an at-risk population.
• Non-contrast abbreviated MRI with alpha foetoprotein has similar diagnostic performance to dynamic contrast-enhanced abbreviated MRI and complete MRI, including when considering small size hepatocellular carcinoma  ≤ 2 cm.
• Non-contrast abbreviated MRI and dynamic contrast-enhanced abbreviated MRI can be performed in 7 and 10 min, excluding patient setup time.
Simulation of present and future land subsidence in the Rafsanjan plain, Iran, due to groundwater overexploitation using numerical modeling and InSAR data analysis
Authors: Bockstiegel M. , Richard-Cerda J. C. , Muñoz-Vega E. , Haghighi M. H. , Motagh M. , Lalehzari R. , Schulz S. 
Published: July 2023

AbstractIn the Rafsanjan plain, Iran, the excessive use of groundwater for pistachio irrigation since the 1960s has led to a severe water level decline as well as land subsidence. In this study, the advantages of InSAR analyses and groundwater flow modeling are combined to improve the understanding of the subsurface processes causing groundwater-related land subsidence in several areas of the region. For this purpose, a calibration scheme for the numerical groundwater model was developed, which simultaneously accounts for hydraulic aquifer parameters and sediment mechanical properties of land subsidence and thus considers the impact of water release from aquifer compaction. Simulation results of past subsidence are calibrated with satellite-based InSAR data and further compared with leveling measurements. Modeling results show that land subsidence in this area occurs predominantly in areas with fine-grained sediments and is therefore only partly dependent on groundwater level decline. During the modeling period from 1960 to 2020, subsidence rates of up to 21 cm year−1 are simulated. Due to the almost solely inelastic compaction of the aquifer, this has already led to an irreversible aquifer storage capacity loss of 8.8 km3. Simulation results of future development scenarios indicate that although further land subsidence cannot be avoided, subsidence rates and the associated aquifer storage capacity loss can be reduced by up to 50 and 36%, respectively, by 2050 through the implementation of improved irrigation management for the pistachio orchards.
Oral Focal Mucinosis of the Tongue: A Rare Localization for a Rare Entity
Authors: Martínez-Ortega Jesús I. , Gómez-Torres Rosa E. 
Published: July 2023

Abstract:
Oral focal mucinosis (OFM) is a rare connective tissue disorder that is characterized by the excessive production of hyaluronic acid due to myxoid degeneration of submucosal connective tissue. The disorder typically presents as an asymptomatic nodule or mass in the gingiva or hard palate, and OFM of the tongue is even more unusual. In this report, we present a case of OFM on the tongue in a 72-year-old female patient who presented with a symptomatic lump that had been growing for 6 months on the dorsum of her tongue. The patient reported discomfort and pain while speaking and swallowing, and the lump was visually apparent on examination. OFM is a benign condition that does not have any specific clinical or radiographical features that distinguish it from other more common oral lesions, such as lipoma or fibroma. Therefore, histopathological examination is essential for a definitive diagnosis. The management of OFM typically involves surgical excision of the lesion. In this case, complete surgical removal of the lesion under general anesthesia was performed, and the patient was followed up for 10 months postoperatively. During the follow-up period, there was no evidence of recurrence, and the patient reported significant improvement in her symptoms. In conclusion, OFM is a rare connective tissue disorder that can occur in the oral cavity. Although OFM of the tongue is even rarer, it should be considered in the differential diagnosis of oral lesions. Histopathological examination is essential for definitive diagnosis, and surgical excision is typically the preferred treatment modality.
Robust chromatin state annotation
Authors: Foroozandeh Shahraki Mehdi , Farahbod Marjan , Libbrecht Maxwell 
Published: July 2023

AbstractBackgroundSegmentation and genome annotations (SAGA) methods such as ChromHMM and Segway are widely to annotate chromatin states in the genome. These algorithms take as input a collection of genomics datasets, partition the genome, and assign a label to each segment such that positions with the same label have similar patterns in the input data. SAGA methods output an human-interpretable summary of the genome by labeling every genomic position with its annotated activity such as Enhancer, Transcribed, etc. Chromatin state annotations are essential for many genomic tasks, including identifying active regulatory elements and interpreting disease-associated genetic variation. However, despite the widespread applications of SAGA methods, no principled approach exists to evaluate the statistical significance of SAGA state assignments.ResultsTowards the goal of producing robust chromatin state annotations, we performed a comprehensive evaluation of the reproducibility of SAGA methods. We show that SAGA annotations exhibit a large degree of disagreement, even when run with the same method on replicated data sets. This finding suggests that there is significant risk to using SAGA chromatin state annotations.To remedy this problem, we introduce SAGAconf, a method for assigning a measure of confidence (r-value) to SAGA annotations. This r-value is assigned to each genomic bin of a SAGA annotation and represents the probability that the label of this bin will be reproduced in a replicated experiment. This process is analogous to irreproducible discovery rate (IDR) analysis that is commonly used for ChIP-seq peak calling and related tasks. Thus SAGAconf allows a researcher to select only the reliable parts of a SAGA annotation for use in downstream analyses.SAGAconf r-values provide accurate confidence estimates of SAGA annotations, allowing researchers to filter out unreliable elements and remove doubt in those that stand up to this scrutiny.
Effects of nutritional supplements on antibody levels in pregnant women vaccinated with inactivated SARS-CoV-2 vaccines
Authors: Zhang Xi , Han Xue , Chen Baolan , Fu Xi , Gong Yajie , Yang Wenhan , Chen Qingsong 
Published: July 2023

AbstractBackgroundBecause of the significantly higher demand for nutrients during pregnancy, pregnant women are more likely to have nutrient deficiencies, which may adversely affect maternal and fetal health. The effect of nutritional supplements on the immune effects of inactivated SARS-CoV-2 vaccines during pregnancy is not clear.MethodsIn a multicenter cross-sectional study, we enrolled 873 pregnant women aged 18-45 y in Guangdong, China. The general demographic characteristics of pregnant women and their use of nutritional supplements were investigated, and the serum antibody levels induced by inactivated SARS-CoV-2 vaccines were measured. A logistic regression model was used to analyze the association between nutritional supplements and SARS-CoV-2 antibody levels.ResultsOf the 873 pregnant women enrolled, 825 (94.5%) took folic acid during pregnancy, 165 (18.9%) took iron supplements, and 197 (22.6%) took DHA. All pregnant women received at least one dose of inactivated SARS-CoV-2 vaccine, and the positive rates of serum SARS-CoV-2 neutralizing antibodies (NAbs) and immunoglobulin G (IgG) antibodies were 44.7% and 46.4%, respectively. After adjustment for confounding factors, whether pregnant women took folic acid, iron supplements, or DHA did not influence NAb positivity or IgG positivity (P> 0.05).Compared with pregnant women who did not take folic acid, the odds ratios (ORs) for the presence of SARS-CoV-2 NAb and IgG antibody in pregnant women who took folic acid were 0.69 (P= 0.282; 95% CI, 0.35-1.35) and 1.31 (P= 0.456; 95% CI, 0.64-2.67), respectively. Compared with pregnant women who did not take iron supplements, the ORs for the presence of NAb and IgG antibody in pregnant women who took iron supplements were 1.22 (P= 0.336; 95% CI, 0.81-1.84) and 1.01 (P= 0.956; 95% CI, 0.66-1.54), respectively. Similarly, the ORs for NAb and IgG antibody were 0.74 (P= 0.125; 95% CI, 0.51-1.08) and 0.97 (P= 0.881; 95% CI, 0.66-1.44) in pregnant women who took DHA compared with those who did not.ConclusionsNutritional supplementation with folic acid, iron, or DHA during pregnancy was not associated with antibody levels in pregnant women who received inactivated SARS-CoV-2 vaccines.
Estimating the true stability of the prehydrolytic outward-facing state in an ABC protein
Authors: Simon Márton A. , Iordanov Iordan , Szöllősi András , Csanády László 
Published: July 2023

AbstractCFTR, the anion channel mutated in cystic fibrosis patients, is a model ABC protein whose ATP-driven conformational cycle is observable at single-molecule level in patch-clamp recordings. Bursts of CFTR pore openings are coupled to tight dimerization of its two nucleotide binding domains (NBDs) and in wild-type (WT) channels are mostly terminated by ATP hydrolysis. The slow rate of non-hydrolytic closure – which determines how tightly bursts and ATP hydrolysis are coupled – is unknown, as burst durations of catalytic site mutants span a range of ∼200-fold. Here we show that Walker A mutation K1250A, Walker B mutation D1370N, and catalytic glutamate mutations E1371S and E1371Q all completely disrupt ATP hydrolysis. True non-hydrolytic closing rate of WT CFTR approximates that of K1250A and E1371S. That rate is slowed ∼15-fold in E1371Q by a non-native inter-NBD H-bond, and accelerated ∼15-fold in D1370N. These findings uncover unique features of the NBD interface in human CFTR.
Chromosome level assembly of wild spinach provides insights into the divergence of homo- and heteromorphic plant sex-chromosomes
Authors: Severing Edouard I. , van der Werf Edwin , van Kaauwen Martijn P.W. , Kodde Linda , Kik Chris , van Treuren Rob , Visser Richard G.F. , Finkers Richard , Bai Yuling 
Published: July 2023

AbstractBackgroundCultivated spinach (Spinacia oleracea)is a highly nutritional crop species of great economical value that belongs to a genus of dioecious plant species with both homomorphic and heteromorphic sex chromosomes. The wild spinach speciesSpinacia turkestanicaandSpinacia tetrandraare important genetic sources for improving cultivated spinach and excellent material for studying sex chromosome evolution in plants. However, until now there were no publicly available genome assemblies for these species.ResultsHere we sequenced and assembled the genomes ofS. turkestanicaandS. tetrandraand performed a tri-way comparative analysis withS. oleracea. We show that many abiotic- and biotic stress related gene clusters have expanded through tandem duplication inS. tetrandraafter it diverged from theS. turkestanica-S. oleracealineage. Focussing on the sex chromosomes we found that the previously identified inversion distinguishing theS. oleraceamale- and female-SEX DETERMINING REGIONs (SDRs) is conserved inS. turkestanica. Although, the SDRs of these two species coincides with the PSEUDO AUTOSOMAL REGION ofS. tetrandrathe gene content is only partially conserved and the genetic factors determining sex in these species might differ. Finally, we show that recombination suppression between theS. tetrandraX- and Y-chromosomes resulted in a highly degenerated Y-chromosome and started before the species diverged fromS. turkestanicaandS. oleracea.ConclusionsWe expect that the novel wild spinach species genomes are of great value to the breeding community and evolutionary biologist especially focussing on the evolution of sex chromosomes in plants.
Brown Adipose Tissue and BMP3b Decrease Injury in Cardiac Ischemia-Reperfusion
Authors: Martí-Pàmies Íngrid , Thoonen Robrecht , Morley Michael , Graves Lauren , Tamez Jesus , Caplan Alex , McDaid Kendra , Yao Vincent , Hindle Allyson , Gerszten Robert E. , Farrell Laurie A. , Li Li , Tseng Yu-Hua , Profeta Gerson , Buys Emmanuel S. , Bloch Donald B. , Scherrer-Crosbie Marielle 
Published: July 2023

BACKGROUND:
Despite advances in treatment, myocardial infarction (MI) is a leading cause of heart failure and death worldwide, with both ischemia and reperfusion (I/R) causing cardiac injury. A previous study using a mouse model of nonreperfused MI showed activation of brown adipose tissue (BAT). Recent studies showed that molecules secreted by BAT target the heart. We investigated whether BAT attenuates cardiac injury in I/R and sought to identify potential cardioprotective proteins secreted by BAT.

METHODS:

Myocardial I/R surgery with or without BAT transplantation was performed in wild-type (WT) mice and in mice with impaired BAT function (uncoupling protein 1 [
Ucp1
]–deficient mice). To identify potential cardioprotective factors produced by BAT, RNA-seq (RNA sequencing) was performed in BAT from WT and
Ucp1

−/−

mice. Subsequently, myocardial I/R surgery with or without BAT transplantation was performed in
Bmp3b
(bone morphogenetic protein 3b)–deficient mice, and WT mice subjected to myocardial I/R were treated using BMP3b.

RESULTS:

Dysfunction of BAT in mice was associated with larger MI size after I/R; conversely, augmenting BAT by transplantation decreased MI size. We identified Bmp3b as a protein secreted by BAT after I/R. Compared with WT mice,
Bmp3b
-deficient mice developed larger MIs. Increasing functional BAT by transplanting BAT from WT mice to
Bmp3b
-deficient mice reduced I/R injury whereas transplanting BAT from
Bmp3b
-deficient mice did not. Treatment of WT mice with BMP3b before reperfusion decreased MI size. The cardioprotective effect of BMP3b was mediated through SMAD1/5/8. In humans, the plasma level of BMP3b increased after MI and was positively correlated with the extent of cardiac injury.

CONCLUSIONS:
The results of this study suggest a cardioprotective role of BAT and BMP3b, a protein secreted by BAT, in a model of I/R injury. Interventions increasing BMP3b levels or targeting Smad 1/5 may represent novel therapeutic approaches to decrease myocardial damage in I/R injury.
Book Reviews
Authors: Cristofoletti Evandro Coggo , Aarnikoivu Melina 
Published: July 2023

Amy J. Binder and Jeffrey L. Kidder (2022), The Channels of Student Activism: How the Left and Right are Winning (and Losing) in Campus Politics Today, Chicago: The University of Chicago Press, 225 pp., ISBN: 978-0-226-68427-7
Julia Molinari (2022), What Makes Writing Academic: Rethinking Theory for Practice, London: Bloomsbury Academic, 224 pp., ISBN: 978-1-3502-4392-7
ОЗОНАТОР ҚОНДЫРҒЫСЫНЫҢ ЭЛЕКТР ЖЕТЕКТЕРІНІҢ КҮЙІН ҚАШЫҚТАН БАҚЫЛАУ ҮРДІСІН ЗЕРТТЕУ
Authors: Абдуллаев Сейдулла , Абдыкадыров Аскар , Сарсанбеков Қурмангазы , Марксұлы Сұңғат , Абдуллаева Асель 
Published: July 2023

Бұл ғылыми мақалада озонатор қондырғысының жабдық күйін қашықтан бақылау жүйесінің дамуы сипатталған. Яғни үрдісті басқарудың автоматтандырылған жүйесіне негізделген. Жұмыстың тенденциялары озон технологиясы саласында цифрландыруды дамытуға бағытталып жасалған.Жүйенің құрылымдық сұлбасы ЭТРО - 03 озонатор қондырғысына әзірленді. Ондағы басты мақсат электр жабдығының күйін қашықтан басқару мен жұмыс орнында отырып пульт көмегімен бақылау. Жүйенің бағдарламалық құрамдас бөліктері таңдалдыжәне олардың арасындағы байланыс архитектурасы күшейтілді. Осы архитектураға сүйене отырып, физикалық қажетті жабдықтар мен бағдарламалық жүйені енгізу жүзеге асырылды. Ұсынылған жұмыснәтижелерін басқа технологиялық объектілерге қолдануға болады, өйткені бұл жүйенің маңызды артықшылығы оның бейімделгіштігі болып табылады. Бұлжүйенің басқа жүйелерге интеграциялану мүмкіндігі бар екені зерттеу жұмысы барысында анықталды.
Implementasi Wewenang Intelejen Kejaksaan dalam Mengungkap Dugaan Tindak Pidana Korupsi di Kabupaten Timor Tengah Utara
Authors: Anmuni Seferinus , Asa Simplexius , Amalo Heryanto 
Published: July 2023

Kejaksaan Negeri Timor Tengah Utara merupakan salah satu unit kerja Kejaksaan Republik Indonesia yang berkedudukan di Kabupaten Timor Tengah Utara yang melalui seksi Intelejennya secara nyata telah melakukan usaha pemberantasan tindak pidana korupsi di wilayah hukumnya. Meskipun demikian dalam pelaksanaannya tidak mudah bagi Intelejen Kejaksaan Negeri Timor Tengah Utara untuk mendapatkan temuan-temuan tindak pidana korupsi dan masih terdapat dugaan-dugaan tindak pidana korupsi yang belum tuntas diselesaikan. Penelitian ini merupakan yuridis empiris yakni penelitian yang mengacu pada efektifitas hukum. Jenis dan sumber data yang diperoleh adalah melalui wawancara sebagai data primer dan didukung dengan data sekunder yang berasal dari buku, peraturan perundang-undangan dan lain-lain. Data yang diperoleh akan diolah dan dianalisis secara dekskriptif-kualitatif. Hasil penelitian ini menunjukan bahwa (1) Kejaksaan merupakan satu landasan dalam pelaksanaan tugas dan wewenangnya di bidang penuntutan, tidak ada lembaga lain yang berhak melakukan penuntutan kecuali yang berada di bawah kendali Jaksa Agung sehingga dimanapun jaksa berada baik jaksa yang dikaryakan Komisi Pemberantasan korupsi (KPK) maupun jaksa yang ditugaskan di daerah merupakan bagian yang tidak terpisahkan dari lembaga kejaksaan. (2) Melakukan kegiatan penyelidikan, pengamanan, dan penggalangan untuk melakukan pencegahan tindak pidana guna mendukung penegakan hukum dan memberikan dukungan intelejen kejaksaan bagi keberhasilan tugas dan kewenangan kejaksaan, melakukan koordinasi serta pemantapan kesadaran hukum masyarakat. (3) Melakukan kegiatan penyelidikan sejak dikeluarkan surat perintah dimulainya penyelidikan kemudian hasil temuan dari penyelidikan diolah dan dianalisis kemudian diberikan kepada pimpinan untuk dipelajari.
Hubungan Akseptor Keluarga Berencana Suntik “DMPA” dengan Kejadian Disfungsi Seksual Wanita di Puskesmas Ciwandan
Authors: Fathiyati Fathiyati , Sari Dwinda , Mardianti Lina 
Published: July 2023

This article to analyze the relationship between the use of medrox progesterone acetate (DMPA) depot injectable contraceptives with the incidence of female sexual dysfunction at the Ciwandan Health Center in December 2021. This type of research is an analytical survey with a cross sectional design design. The population used in this study was family planning acceptors in the CiwandanHealth Center area. This research was conducted from August to December 2021 at the Puskesmas Ciwandan. The results shows that there is a significant relationship between DMPA contraceptive use and female sexual dysfunction at the Puskesmas CiwandanSerang Banten in 2021 with P-Value = 0.000 < 0.005. With a value of OR = 46,550, it can be concluded that Women who use DMPA contraception have a 46.5 times chance of experiencing sexual dysfunction compared to Women who do not use DMPA contraception.

Tujuan artikel ini untuk menganalisis hubungan penggunaan kontrasepsi suntik depot medrox progesterone acetate (DMPA) dengan kejadian disfungsi seksual wanita di Puskesmas Ciwandan Desember Tahun 2021 Jenis penelitian ini adalah survey analitik dengan desain rancangan cross sectional. Populasi yang digunakan dalam penelitian ini adalah akseptor KB yang ada di wilayah Puskesmas Ciwandan. Penelitian ini dilakukan pada bulan Agustuas s/d Desember Tahun 2021 di Puskesmas Ciwandan. Hasil Penelitian menunjukan Ada hubungan yang signifikan antara penggunaan kontrasepsi DMPA dengan disfungsi seksual wanita Di Puskesmas CiwandanSerang Banten Tahun 2021 dengan P-Value = 0,000 < 0,005. Dengan nilai OR = 46,550, sehingga dapat disimpulkan bahwa Wanita yang menggunakan kontrasepsi DMPA memiliki peluang 46,5 kali untuk mengalami disfungsi seksual dibandingkan dengan Wanita yang tidak menggunakan kontrasepsi DMPA.
Organisationale Aspekte in Implementierungsprozessen
Authors: Schäfer Sandra 
Published: July 2023

Was ist zu diesem Thema bereits bekannt? Die Implementierung von Innovationen in komplexen Organisationen wie Einrichtungen des Gesundheitswesens wird von verschiedenen Faktoren auf mehreren Ebenen beeinflusst. Wie wird eine neue Perspektive eingebracht? Der Zusammenhang zwischen organisationalen Aspekten und einer nachhaltigen Implementierung wird beleuchtet. Wichtige Faktoren für eine Implementierung sind neben den verfügbaren Ressourcen die Organisationskultur, das Veränderungsklima sowie eine begeisterungsfähige Führung. Was sind die Auswirkungen für die Praxis? Eine wichtige Voraussetzung für die Praxis ist eine genaue Analyse der vorherrschenden Rahmenbedingungen durch alle Beteiligten des Implementierungsprozesses.