bluuebunny/crossref_metadata_2025_split huggingface dataset:
Percutaneous Nephrostomy in Kidney Transplant Recipients: Incidence, Risk Factors, Complications and Outcomes
Authors: Alhassoun Alia , Alkhatib Bassel , Idilbi Amro , Hallak Mohamed Hussam , Ghanem Roaa , Hanouneh Tareq , Jarmi Tambi 
Published: January 2025

ABSTRACTUreteral stenosis is a frequent complication after kidney transplantation, causing significant morbidity and potential graft function impairment. Treatment options include conservative management, endourological procedures, surgical interventions and percutaneous nephrostomy (PCN). While PCN effectively relieves obstruction, it comes with its own complications. This study evaluates the risk factors, incidence, complications and outcomes of PCN in this population.We conducted a retrospective case series analysis of 98 kidney transplant recipients who underwent PCN. Data on demographics, clinical characteristics and procedural outcomes were collected and analysed to assess the incidence of complications and identify associated risk factors.Among the 98 recipients, the median age at transplant was 56 years, with 52% being male. The most common comorbidities included hypertension (75.5%) and diabetes mellitus (35.7%). Complications occurred in 38.8% of patients, with infections being the most frequent (74.4%), including urinary tract infections (28.9%) and pyelonephritis (22.4%). The primary organisms identified were gram‐negative bacteria (55.1%). Reconstructive surgery was required in 35.7% of cases and patient survival was 83.7% at follow‐up.In conclusion, PCN in kidney transplant recipients is associated with a high rate of complications, particularly infections. Effective management necessitates the identification and addressing of associated risk factors such as diabetes, elevated BMI and specific induction therapies. While PCN is vital for preserving graft function, further research should focus on refining clinical protocols and developing targeted preventive strategies for high‐risk patients.
Artificial Intelligence to Predict Chronic Kidney Disease Progression to Kidney Failure: A Narrative Review
Authors: Miller Zane A. , Dwyer Karen 
Published: January 2025

ABSTRACTChronic kidney disease is characterised by the progressive loss of kidney function. However, predicting who will progress to kidney failure is difficult. Artificial Intelligence, including Machine Learning, shows promise in this area. This narrative review highlights the most common and important variables used in machine learning models to predict progressive chronic kidney disease. Ovid Medline and EMBASE were searched in August 2023 with keywords relating to ‘chronic kidney disease’, ‘machine learning’, and ‘end‐stage renal disease’. Studies were assessed against inclusion and exclusion criteria and excluded if variables inputted into machine learning models were not discussed. Data extraction focused on specific variables inputted into the machine learning models. After screening of 595 articles, 16 were included in the review. The most utilised machine learning models were random forest, support vector machines and XGBoost. The most commonly occurring variables were age, gender, measures of renal function, measures of proteinuria, and full blood examination. Only half of all studies included clinical variables in their models. The most important variables overall were measures of renal function, measures of proteinuria, age, full blood examination and serum albumin. Machine learning was consistently superior or non‐inferior when compared to the Kidney Failure Risk Equation. This review identified key variables used in machine learning models to predict chronic kidney disease progression to kidney failure. These findings lay the foundations for the development of future machine learning models capable of rivalling the Kidney Failure Risk Equation in the provision of accurate kidney failure prediction.
Proteinuria's Influence on Clinical Outcomes and Prognostic Accuracy in Acute Ischaemic Stroke Patients Undergoing Reperfusion Therapy: A Comprehensive Meta‐Analysis
Authors: Rajesh Kruthajn , Bhaskar Sonu M. M. 
Published: January 2025

ABSTRACTAimProteinuria commonly accompanies acute ischaemic stroke (AIS) patients undergoing reperfusion therapies such as intravenous thrombolysis (IVT) and endovascular thrombectomy (EVT). Understanding its influence on outcomes is crucial for prognosis and optimising management strategies. This study aims to elucidate proteinuria's role in mediating outcomes among reperfusion‐treated patients.MethodsThrough a random‐effects meta‐analysis, we analysed data to assess the association of proteinuria with functional outcomes, symptomatic intracerebral haemorrhage (sICH) and mortality. A total of 33 140 patients were included in the meta‐analysis.ResultsProteinuria demonstrated a pooled prognostic sensitivity of 58% (95% CI: [48%; 67%]; p < 0.001) for poor functional outcomes at 90 days. It was linked with increased odds of unfavourable functional outcome at 90 days in both IVT (OR 2.27; 95% CI: [1.95; 2.66]; p < 0.001) and EVT (OR 2.57; 95% CI: [2.16; 3.05]; p < 0.001) groups. Furthermore, it was associated with increased odds of 90‐day mortality in IVT‐treated patients (OR 2.31; 95% CI: [1.76; 3.02]; p < 0.001), while EVT‐treated patients exhibited increased odds of in‐hospital mortality (OR 2.71; 95% CI: [1.22; 6.04]; p < 0.05).ConclusionsThe clinical significance of proteinuria is underscored by its impact on outcomes for AIS patients receiving reperfusion treatments. This awareness may guide individualised treatment by considering the intricate interplay between kidney function and its correlation with stroke. Consequently, this has the potential to improve prognosis and overall outcomes in AIS therapy.
Maternal Prepregnancy Obesity and Offspring Intelligence Quotient at 5 Years: A Multicohort Analysis
Authors: Dow Courtney , Lorthe Elsa , Bernard Jonathan Y. , Galera Cédric , Marchand‐Martin Laetitia , Tafflet Muriel , Ancel Pierre‐Yves , Charles Marie‐Aline , Heude Barbara 
Published: January 2025

ABSTRACTBackgroundThe relationship between maternal obesity and childhood cognitive development remains unclear. Prior studies did not adjust for important confounders, and preterm infants are a developmentally distinct group that remains scarcely examined.ObjectivesTo determine whether maternal prepregnancy body mass index (BMI) is associated with offspring intelligence quotient (IQ) up to 5 years and whether this relationship varies with gestational age.MethodsData from two French birth cohorts, EDEN (all gestational ages) and EPIPAGE‐2 (preterm children born between 24 and 34 weeks of gestation), were used for this study. Maternal prepregnancy weight and height were used to calculate prepregnancy BMI. The Wechsler Preschool and Primary Scale of Intelligence was used to assess child IQ around 5 years. Multivariable models were adjusted for confounders, including socioeconomic status and paternal BMI.ResultsAnalytical cohorts included 1100 children from EDEN and 2629 from EPIPAGE‐2. Lower intellectual functioning (full‐scale IQ < 85) was observed in 8.1% of children in EDEN and 19.6% in EPIPAGE‐2. The prevalence of maternal obesity was 13.6% (EDEN) and 21.3% (EPIPAGE‐2) among children with lower intellectual functioning compared to 8.9% (EDEN) and 12.9% (EPIPAGE‐2) among children with normal intellectual functioning. Maternal prepregnancy obesity was associated with an approximately 3‐point decrease in full‐scale IQ scores in fully adjusted models (adjusted β −2.8, 95% confidence interval [CI] −5.6, −0.1 and −2.6, 95% CI −4.7, −0.6 in EDEN and EPIPAGE‐2, respectively). In EDEN, maternal obesity was associated with lower scores in the verbal IQ domain. Among infants born preterm (EPIPAGE‐2), maternal obesity was associated with lower scores in the processing, reasoning, and verbal IQ domains. Adjustment for paternal BMI did not change the magnitude of the relationship with maternal obesity.ConclusionsHigh maternal prepregnancy BMI is associated with child cognitive development around 5 years of age.
Natural farming needs manure augmentation to optimize soil quality and crop productivity
Authors: Thakur Praveen , Paliyal Sukhdev Singh , Kumar Pardeep , Raj Yog , Thakur Pratibha , Dev Purushottam , Thakur Anjali , Butail Nagender Pal , Gill Ankit 
Published: January 2025

AbstractWhile assuming natural farming (NF) superior over conventional farming in improving physical, chemical and biological attributes, we hypothesized that the inclusion of farmyard manure (FYM) in addition to NF components would further enhance the soil quality and productivity. The objectives of the study were to assess the efficacy of NF in maize–blackgram intercropping, evaluating effect on soil quality of FYM‐integrated NF, and to identify key soil quality indicators under rainfed agroecosystem. Over a 2 years span, the factorial experiment employed Jeevamrit concentrations (J1: 5% and J2: 10%), application intervals (I1: 15 days and I2: 30 days) and FYM levels (F1: 0 t FYM ha−1, F2: 5 t FYM ha−1 and F3: 10 t FYM ha−1) as factors, resulting in 12 combinations arranged in a randomized block design under maize intercropped blackgram. An additional recommended dose of fertilizers (RDF) enabled an orthogonal contrast to compare effects of conventional farming and bio‐farming. The results revealed that yield and soil attributes of maize, intercropped with blackgram, were significantly improved with FYM‐augmented NF system. The combined application of 10 t FYM ha−1 and 10% Jeevamrit with 15 days application interval significantly improved the bulk density (1.43 Mg m−3), mean weight diameter of soil aggregates (1.12 mm), saturated hydraulic conductivity (8.13 cm h−1) and plant available water (14.2 cm m−1) over rest of the treatments. The study yielded no evidence supporting the efficacy of NF on its own, as it failed to demonstrate any considerable impact on soil physical, chemical and nutrient attributes from their initial status. However, NF treatments substantially enhanced the biological activity (microbial biomass carbon by 3.88% and dehydrogenase by 21.95%) over treatment receiving RDF. The conventional farming reduced the soil organic carbon content (5.58 g kg−1), along with lower levels of available nitrogen (286 kg ha−1), phosphorus (19.2 kg ha−1) and sulphur (18.4 mg kg−1) when compared to bio‐farming. Application of 10% Jeevamrit at 15‐day span +10 t FYM ha−1 increased the maize grain equivalent yield by 8.65% over conventional farming. Soil quality index measured 0.68 under conventional farming system, 0.73 under NF that further improved to 0.90 with 10 t FYM ha−1 addition. The study demonstrates the potential synergy between FYM and the NF approach, leading to improved soil quality and agricultural productivity.
Development of a simplified platelet cryopreservation method: An in vitro investigation of reducing the DMSO concentration to allow administration without its pre‐transfusion removal
Authors: Johnson Lacey , Lei Pearl , Roan Christopher , Marks Denese C. 
Published: January 2025

AbstractBackground and ObjectivesThe most widely used method of platelet cryopreservation requires the addition of 5%–6% dimethylsulphoxide (DMSO), followed by its pre‐freeze removal via centrifugation, to minimize toxicity. However, this adds complexity to the pre‐freeze and post‐thaw processing. Accordingly, the aim of this study was to simplify platelet cryopreservation by reducing the DMSO concentration and omitting the requirement for pre‐transfusion removal.Materials and MethodsApheresis platelets were cryopreserved at −80°C according to standard blood‐banking methods using 5.5% DMSO, with centrifugation, pre‐freeze removal of DMSO and reconstitution in plasma following thawing (standard). In parallel, doses of DMSO (0%, 1.5%, 3%, 5.5%) were tested without centrifugation and reconstitution (no‐wash). In vitro platelet quality was assessed by flow cytometry, aggregation, viscoelastic testing (thromboelastography [TEG]) and clot retraction.ResultsMany in vitro platelet quality parameters showed DMSO dose dependency using the no‐wash protocol (recovery, annexin‐V, TEG maximum amplitude [MA]). Platelets frozen using the no‐wash method with 3% DMSO showed a higher abundance of GPIbα (3% DMSO no‐wash median fluorescence intensity [MFI]: 228 ± 16; standard MFI: 184 ± 16; p = 0.0016) and less degranulation (reduced P‐selectin‐positive platelets and concentration of supernatant P‐selectin) than platelets frozen using the standard method. All functional properties measured were comparable to those of platelets frozen using the standard method.ConclusionThis study shows that improvements in cryopreserved platelet quality parameters can be obtained by removing the centrifugation processes (standard vs. 5.5% DMSO no‐wash). A reduction in DMSO to 3% supports quality parameters, and if shown to be clinically acceptable, this cryopreservation method could improve platelet accessibility, as it is simpler and cheaper than the standard method.
Perinatal care experiences of women living with disability in Africa: a qualitative systematic review protocol
Authors: Mekonen Dawit Gebeyehu , Snelgrove-Clarke Erna , Macdonald Danielle , Donnelly Catherine , Engeda Eshetu 
Published: January 2025

Objective:
This review will explore the perinatal care experiences of women living with disability in African countries.

Introduction:
In many African countries, most women with disability face stigma and discrimination. They are also at risk of unwanted pregnancy and sexually transmitted diseases due to gender-based violence and sexual abuse. Qualitative studies on perinatal care experiences of women with disability in Africa indicate challenges such as social stereotypes, lack of access to health facilities, and insensitivity from health professionals. Synthesizing the qualitative findings about the perinatal care experiences of women with disability in Africa will provide insights into the needs of this population and identify gaps in health care practice.

Inclusion criteria:
We will include all settings in which women with disability in Africa receive maternal health care services, such as hospitals, clinics, primary care, community health centers, and homes. We will consider studies published from 2008 onward that present qualitative data, including designs such as phenomenology, grounded theory, ethnography, action research, and feminist research.

Methods:
The review will be conducted in line with the JBI methodology for systematic reviews of qualitative evidence. The following databases will be searched: Global Health, CINHAL (EBSCOhost), MEDLINE (Ovid), Web of Science, Embase (Ovid), Sabinet African Journals, and PsycINFO (EBSCOhost). Theses and dissertations will be searched through ProQuest and Google Scholar. Two independent reviewers will conduct study selection, critical appraisal, data extraction, and meta-aggregation. Confidence in the findings will be assessed in accordance with the ConQual approach.

Systematic review registration number:
PROSPERO CRD42023431799.
Paramedic assessment of suspected or confirmed COVID-19 patients in the out-of-hospital environment: a scoping review protocol
Authors: Gleeson-Hammerton Thomas , Pearce James , Eckert Marion , Esterman Adrian , Peters Micah DJ 
Published: January 2025

Objective:
The objective of this review is to develop a comprehensive collection of information about the current processes for paramedics assessing and referring suspected or confirmed COVID-19 patients in the out-of-hospital environment.

Introduction:
Patients with COVID-19 are frequently encountered by paramedics and ambulance service clinicians. Increased demand on ambulance services has resulted in many of these services developing alternative referral pathways to avoid unnecessary conveyance to emergency departments. There is not a strong body of literature or rigorous clinical practice guideline on this topic to support the assessment and referral decision-making for COVID-19 patients in the out-of-hospital setting.

Inclusion criteria:
Any suspected or confirmed COVID-19 patients in the out-of-hospital environment who are seeking care for COVID-19-related symptoms and being assessed by paramedics will be considered for inclusion. Sources from scholarly literature and gray literature, such as ambulance service clinical practice guidelines, will be included. Sources from Australia, Aotearoa New Zealand, USA, Canada, and the UK will be included.

Methods:
The review will be guided by the JBI methodology for scoping reviews and will be reported using the Preferred Reporting Items for Systematic Reviews and Meta-Analysis extension for Scoping Reviews (PRISMA-ScR). A database search for scholarly literature will be performed, followed by a gray literature search. Databases will include MEDLINE, CINAHL, Scopus, Emcare, Embase, amber, JBI Evidence Synthesis, Cochrane Database of Systematic Reviews, and Epistemonikos. Gray literature will include clinical practice guidelines, protocols, and procedures obtained from ambulance service websites and apps. Results will be presented through figurative, tabular, and narrative synthesis methods.

Review registration:
Open Science Framework osf.io/yc7vq
Effect of cochlear implants on cognitive function in children and adolescents with hearing loss: a systematic review protocol
Authors: Jammula Varna , Kramer Nicholas , Manthei Scott , DeArmond Megan , Koshy-Chenthittayil Sherli 
Published: January 2025

Objective:
The objective of this review is to evaluate the effect of cochlear implants on cognitive function in pediatric patients with hearing loss.

Introduction:
Cognitive impairments have been reported in children with hearing loss. This is supported by the auditory scaffolding hypothesis, which describes sound as the basis for processing sequential information. Cochlear implants are proven to be successful in assisting these patients with language and speech recognition. Therefore, understanding whether such implants may additionally improve cognitive function is important for health care professionals in determining whether a child would benefit from a cochlear implant.

Inclusion criteria:
This review will include quantitative studies evaluating cognitive function in pediatric patients (0–18 years) with hearing loss who received unilateral or bilateral cochlear implants. Studies that do not use objective neuropsychological assessments to assess cognitive outcomes will be excluded.

Methods:
PubMed, Embase, CINAHL, Scopus, and PsycINFO will be searched for published studies. Google Scholar, LILACS, Livivo, and ProQuest Dissertation and Theses Global will be searched for unpublished and gray literature. ClinicalTrials.gov, the EU Clinical Trials Register, and WHO’s ICTRP will also be searched for trials. There will be no date or language limitations. Study selection, critical appraisal, and data extraction will be performed by 2 independent reviewers. If meta-analysis is possible, evidence will be summarized using R, with subgroup analyses providing insight into the effect of age, gender, and underlying conditions on the cognitive impairment. Certainty of the evidence will be assessed using the GRADE approach, and a Summary of Findings table will be generated using GRADEpro GDT 2021.

Systematic review registration number:
CRD42024500320
Equitable health care delivery for adult Nova Scotians: a scoping review protocol
Authors: Lane Jennifer , Barber Brittany , McCulloch Holly , Wong Helen , Forbes Neil , Alizadeh Takhtehchoobi Neda , Kuri Marwa , Lackie Kelly , Cassidy Christine , Wozney Lori , Curran Janet , Lane Kris , MacEachern Kendra , Thompson Hallie , O’Brien Cyril , Obeng Nkrumah Elizabeth , Pennell Courtney , Sheppard Darius , Burchell Drew , Macdonald Marilyn 
Published: January 2025

Objective:
The objective of this review is to identify international and Nova Scotian standards of care, CPGs, and policies informing equitable health care.

Introduction:
The lack of attention given to intersectional health care needs of diverse populations perpetuates health inequities among under-served groups, creating an urgent need for health care reform globally.

Inclusion criteria:
This scoping review will include standards of care, CPGs, and policies focusing on equity-related health indicators. Academic and gray literature sources, published from 2014 to present, will be considered if they relate to one or more defined equity-related health indicators. Sources will be excluded if they do not explicitly relate to standards of care, CPGs, or policies for equitable health care delivery.

Methods:
This scoping review will be guided by Intersectionality Theory and conducted in accordance with the JBI methodology for scoping reviews. Academic databases MEDLINE ALL (Ovid) and Embase (Elsevier) will be searched using identified search terms. An advanced Google search will be undertaken to identify gray literature sources. A 2-phased approach will be conducted to identify sources that will be synthesized and presented in tabular format using equity-related health indicators, providing an inventory of health equity standards of care, CPGs, or policies to be disseminated to health care providers in Nova Scotia.

Review registration:
Open Science Framework https://osf.io/6rnx2
Barriers to and facilitators of human trafficking screening in the health care setting: a scoping review protocol
Authors: Hosey Lisa , Palokas Michelle 
Published: January 2025

Objective:
The objective of this scoping review will be to identify barriers to and facilitators of screening children, adolescents, and adults for human trafficking in the health care setting.

Introduction:
Human trafficking is a global issue that violates human rights and undermines the fabric of society. The effects of human trafficking span domestic and international borders, cultures, and socio-economic backgrounds. The magnitude of human trafficking has become increasingly evident, with estimates indicating millions of victims annually.

Inclusion criteria:
This review will consider studies that include children, adolescents, and adults who are either victims or potential victims of human trafficking, and the health care providers caring for them in the health care setting. Studies that report on barriers to and facilitators of screening for human trafficking will be included. Studies may be conducted in any health care setting, in any geographical location or culture.

Methods:
This review will follow the JBI methodology for scoping reviews and will be reported in line with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR). The key databases to be searched will include PubMed, CINAHL (EBSCOhost), PsycINFO (EBSCOhost), and Web of Science Core Collection. Sources of unpublished studies and gray literature will include MedNar and LILACS. Two independent reviewers will retrieve and review full-text studies and extract data. The results will be presented in diagrammatic or tabular format with a narrative summary.

Review registration number:
Open Science Framework https://doi.org/10.17605/OSF.IO/ETX7W