bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of an epigenetic diet on migraine patients
Authors: Kopchak O. O. , Hrytsenko O. Y. 
Published: December 2022

Migraine is a common type of primary headache disorder, distinguished by recurrent attacks of moderate to severe unilateral throbbing pain, often accompanied by symptoms such as nausea, photophobia, and phonophobia.
Objective — to study the effect of epigenetic diet on frequency and intensity of migraine headache attacks, indicators of psycho‑emotional status and quality of life of migraine patients.
Methods and subjects. 130 people aged from 18 to 55 years (average age — 38.6 ± 8.3 years) were examined, of which 15 (11.5 %) were men and 115 (88.4 %) were women. The patients were distributed into two groups: group A — patients who followed an epigenetic diet enriched with 5 mg of folic acid, group B — patients who did not follow any diet. The diagnosis of migraine was confirmed using the criteria of the International Headache Society. Before the study, all participants were assessed using the Work Disability Assessment Scale (MIDAS). Also, the frequency of headache was determined in all patients. Headache intensity was assessed using a visual analog scale (VAS). Psychoemotional status at the beginning and at the end of the study was assessed using the Hamilton Anxiety Scale and the Beck Depression Scale. In all patients, the content of folic acid and homocysteine in the blood was determined using an immunochemical method with electrochemiluminescence detection.
Results. When analyzing the data before the start of the study, it was found that the average concentration of folic acid in group A was 2.8 ± 3.6 ng/ml and was significantly lower than in group B (p = 0.003). The average level of homocysteine was different in both groups (р = 0.04). In group A, against the background of using an epigenetic diet, the average level of folic acid remarkably increased (p = 0.001), and the average level of homocysteine significantly decreased (p = 0.003). Also, in group A, a notable decrease in the intensity and frequency of headache was found (р = 0.02; р = 0.04), a decrease in the average level of anxiety according to the Hamilton scale (from 15.0 ± 3.5 points to 9 ± 2 points) (p = 0.03). A direct relationship between the level of homocysteine and the score on the Hamilton Anxiety Scale and the MIDAS scale was established, as well as a negative correlation between the level of folic acid and the score on the Beck Depression Scale.
Conclusions. Evidence of the influence of changes in the content of homocysteine and folic acid in the blood of patients with migraine against the background of an epigenetic diet on the severity of headache and quality of life was revealed. The use of an epigenetic diet in the prevention and treatment of migraine needs further study, as it is difficult to predict the final effect of the diet due to its low specificity to the epigenome and the large number of interactions between the active components of the diet.
Treatment of superior oblique myokymia with pregabalin. Review of a clinical case
Authors: Kurus Y. V. , Kyryliuk S. Y. , Nehrych T. I. 
Published: December 2022

Superior oblique myokymia is a rare idiopathic disease, characterized by sudden, spontaneous, unilateral, rhythmic contractions of the superior oblique muscle and typically presents with monocular oscillopsia and diplopia. This pathological condition most often affects middle‑aged patients without concomitant systemic diseases. The aim of the article was to study the features of the clinical course, diagnosis and methods of treatment of superior oblique myokymia based on a clinical case. A review of a clinical case of superior oblique myokymia in a patient born in 1983 is presented. The diagnosis was established on the basis of clinical manifestations in the form of sudden episodes of vertical oscillopsia and diplopia in the field of vision of the right eye, which occurred both spontaneously during prolonged work at the computer, driving a vehicle, and in response to light stimulation. A 38‑year‑old patient described the disease as the presence of periodic attacks, during which blurred vision, doubling and movement of objects in the field of vision of the right eye occurred for 2 — 3 seconds, after which the vision returned to normal. The number of attacks was up to 100 per day and significantly worsened the patient’s quality of life. During the neurological examination, an episode of vertical oscillopsia with diplopia was revealed when light was directed at the right eye. No other pathological changes were observed in the nervous system, eyes and other systems and organs, which was confirmed by laboratory and instrumental examination methods, examinations and consultations of different specialists. The patient had a positive therapeutic effect in the treatment of superior oblique myokymia with pregabalin at a dose of 150 mg per day. Recommendations to reduce the time spent working at the computer and to adopt a healthy lifestyle were important.
Thus, superior oblique myokymia is a rare pathological condition manifested by sudden episodes of monocular vertical oscillopsia and diplopia. Pregabalin can be considered as the medication of choice in the treatment of this disease. Further research is needed to establish unified treatment guideline.
CHARACTERISTICS OF THE EXTERIOR OF THE POLESIE HORSE POPULATION OF DIFFERENT AGES
Authors: Ilnytska T. Y. , Sydorenko O. V. 
Published: December 2022

The article is devoted to the problem of studying the features of the development of the exterior of the horses of the Polesie population of Ukraine. A survey of the horses of the Polesie population of the Sherbaty Zugli farm, which are kept on the basis of the Ecological Research Station "Glyboki Balyky" of the Obukhovskyi district of the Kyivska region, was carried out. Today, the herd of Polesie horses has 22 heads. Measurements, assessment of the exterior, movements, temperament and performance of the studied herd of animals of different ages were carried out. Animals were evaluated according to the target standard of the main conformation traits of the Polesie horse population. According to the results of a comprehensive survey of horses of the Polesie population, it was found that young horses born in 2020–2021 are sufficiently developed for their age. Horses of 2.5 years of age are almost as large as adult animals. The difference is determined only by the girth of the chest (6.4 cm). There is also a rapid achievement of physiological maturity, which is characteristic of native breeds.
It was noted that horses of the Polesie population, as well as typical representatives of local breeds, are characterized by: a rectangular shape of the body (92.0 ± 0.84), a large head (96.8 ± 1.31), a fairly pronounced right angle of the forearm (106.0 ± 1.07), small-sickle limbs (96.0 ± 1.69) and bone development proportional to body size (100.0 ± 0.84). A slight variability of the coefficient of variation (2.28–7.28%) was established.
The studied herd fully complies with the requirements of the target color standard - the majority of horses are black or black-roan (56%). Also, most horses (75%) have signs of atavism characteristic of forest horses: transverse stripes on the legs, the so-called "zebroid", dark "plaque" on the shoulders and withers. Based on the research results, taking into account the experience of scientists from other countries, methodological recommendations have been developed for the assessment and selection of horses of the Polesie population with their subsequent introduction into production.
Taking into account the difficult situation in the country and the small number of the studied horses, the issue of studying the features of the external development of horses in the Polesie population requires further research.
Effects of different dose of nitrogen and lime on soil properties and maize (Zea mays L.) on acidic nitisols of Northwestern Ethiopia
Authors: Amare Birtukan , Molla Eyayu , Selassie Yihenew G. , Belay Habtamu Tadele , Bayu Tesfaye 
Published: December 2022

This study was carried out on the nitisols of Burie district, Ethiopia to examine the effect of integrated use of lime and nitrogen on soil physicochemical properties and maize yield. Two levels of lime (0 and 0.5 t/ha) and five-level of nitrogen (0, 46, 92, 138 and 184 kg N/ ha) were laidout in randomized complete block design with three replications. The results indicated that among before planting, soil bulk density (BD), pH, soil organic carbon (OC), total nitrogen (TN), available P and CEC were 1.42 g/cm3, 5.2 (strongly acidic), 1.32% (very low), 0.12% (low), 8.86 mg /kg (very low), and 19.57 cmolc /kg (medium), respectively. The physicochemical properties except bulk density increased. The lowest soil BD (1.21 g/m3) was from plots treated with 0.5 t/ha lime and 184 kg N/ ha. The maximum soil pH (6.85) was obtained from plots treated with 184 kg N/ ha and 0.5 t/ha lime. The maximum soil CEC (35.38 (cmolc /kg) was obtained from plots treated with 184 kg N/ ha and 0.5 t/ha lime. Level of lime, nitrogen fertilizer, and interaction effects of lime and nitrogen fertilizer (L×N) significantly affected maize yield (p<0.001). Indeed yield of maize has positive correlations with most soil physicochemical properties but negative with BD (r= -0.543). The adjusted yield and net benefits was 6.4 t/ha and 1101.77$. Inherent physicochemical properties of the soil are changed either by sole or combined use of lime and N fertilizer. Soils tilled with 0.5 t/ha lime and 138 kg/ha nitrogen were found in maximum net benefit. Residual long-term effects should be researched. Thus, liming should be given an emphasis on acidic soil amelioration. Moreover, the government may facilitate the supply of lime and nitrogen fertilizer to the farmers.
Partes Concerts of the 1730s–1740s from the Kyiv Collection: New Assets
Authors: Ignatenko Yevgeniya 
Published: December 2022

Relevance and current status of research. The Kyiv collection of partes music, which is kept in the Institute of Manuscript of V. Ι. Vernadsky National Library of Ukraine, is the largest in Ukraine. It includes about 700 choral works, and only a few dozen of them have been decoded, edited and published. In 2020, within the Musica sacra Ukraina project the author of this article decoded and prepared for performance three new partes concerts from the Kyiv collection. These are twelve-part anonymous concerts of the 1730 s – 40 s “The troubles of my heart”, “O sing unto the Lord a new song” and “Come, o people”.
The purpose of the study is to describe the Kyiv partes collection and the current status of its research; to outline the main steps of working with partes manuscripts: deciphering, score compiling and editing; to present deciphered concerts in the context of current research problems of European baroque music, such as the aesthetics of oddity, as well as musical symbolism and rhetoric, which allow us to reveal the inextricable connection between the verbal and musical text of the works.
Methodological framework. The work is based on proven methodologies of decoding and scientific editing of handwritten musical text, and methods of musical theoretical analysis are also used.
Results and scientific novelty of the work. Three anonymous twelve-part partes concerts of the 1730 s –1740 s from the Kyiv collection “The troubles of my heart”, “O sing unto the Lord a new song” and “Come, o people” were deciphered, edited and analyzed. A comprehensive approach to studying Ukrainian baroque music is presented. It involves deciphering, editing (preparation for performance) and musicological interpretation of the work. The proposed musicological analysis, which is based on modern approaches to the analysis of baroque music, updates the European context of the Ukrainian baroque heritage
Ultrastructural reorganization of the constituent components of the rat periodontium under conditions of chronic opioid exposure
Authors: Fik V. B. , Podolіyk М. V. , Matkivska R. M. 
Published: December 2022

Opioid addiction has acquired the characteristics of an epidemic in recent years and is a serious problem in modern medicine. In users of narcotic substances, a significant prevalence of diseases of the oral cavity and periodontal tissues is noted in comparison with the general population. The aim of the work was to investigate the ultrastructural organization of the periodontal tissues of rats at the end of the fourteenth week of the experimental opioid effect. The animals were administered intramuscularly, daily, once, the opioid analgesic nalbuphine (pharmacotherapeutic group: analgesics, opioids, morphinan derivatives) in increasing doses for 14 weeks: 1-2 weeks – 0.212 mg/kg, 3-4 weeks – 0.225 mg/kg, 5-6 weeks – 0.252 mg/kg, 7-8 weeks – 0.260 mg/kg, 9-10 weeks – 0.283 mg/kg; 11-12 – 0.300 mg/kg, 13-14 weeks – 0.450 mg/kg. At the end of the fourteenth week of opioid exposure, ultrastructural changes in the epithelium of the mucous membrane of the gums, periodontium, and hemomicrovessels with the development of decompensation and pronounced dystrophic-destructive changes were established. With the long-term effect of an opioid analgesic, signs of karyorrhexis, segregation of nucleoli, spongiosis, apoptosis, violation of the integrity of intercellular contacts, as well as vacuole-like formations, which were a manifestation of focal necrosis of epitheliocytes, were revealed. The development of necrotic changes was caused by significant damage and destruction of organelles, as well as fragmentation or lysis of bundles of tonofilaments. The intercellular spaces were mostly expanded and uneven, which was caused by edematous phenomena. Fragmentation and destruction of periodontal collagen fibers, destructive changes in fibrocytes and fibroblasts were found in the periodontium. The translucency of the amorphous component of the intercellular substance of the connective tissue was determined. The ultrastructural reorganization of the cellular components of the periodontium was caused by vascular disorders of a systemic nature, which were manifested by the phenomena of dilatation, hemoptysis, sludge phenomenon, dystrophic changes in the endotheliocytes of hemocapillaries and venules, and the progression of sclerotic changes, which significantly disturbed the trophism of the periodontal tissues of rats.
Neuron-glial relations of the posterior horns of the spinal cord of human fetuses
Authors: Prykhodko S. O. , Shkolnikov V. S. 
Published: December 2022

Despite the relatively sufficient study of the structure and functioning of the nervous system, interest in the problem of neuron-glial relationships continues to grow steadily, as this parameter reflects the dynamics of the development of nervous tissue and can be used to assess the quality level of morphological changes. The purpose of the study: to establish the morphogenesis and neuron-glial relationships of the posterior horns of the human spinal cord in the fetal period of ontogenesis. This study was performed on the preparations of 104 human fetuses from 8-9 weeks to 39-40 weeks using anatomical, histological, immunohistochemical and morphometric methods. Statistical processing of the numerical data of the obtained results was carried out using the licensed software package “Statistica 6.1” of the StatSoft company using parametric and non-parametric methods. During the research, it was established that in the fetal period, the greater proliferative activity of the dorsal neuroepithelium is determined at 8-9 weeks: in the cervical segments – 10 % (р<0.05), in the thoracic, lumbar and sacral segments – 9 % (р<0.05). By 39-40 weeks, this indicator gradually becomes smaller: in the cervical and lumbar segments, 4 % of cells (2-3 cells reacted) (p<0.05) and in the thoracic and sacral segments – 3 % (1-2 cells reacted) (p<0.05). It was found that throughout the fetal period there is a tendency to a gradual decrease in the density of neurons and gliocytes. The glial index, on the contrary, up to 39-40 weeks increases, and at the time of birth it is equal to 2.1 in the cervical, thoracic and lumbar segments, and 2.0 in the sacral segments. It was found that at 11-12 weeks, radial glia fibers form mesh structures within the neuronal complexes, which coincides with the beginning of the formation of neuron-glial complexes of the posterior horns. At 17-18 weeks, the fibers of radial glia keep the radial direction only in the middle part of the posterior horns. At 34-35 weeks, vimentin expression was determined to be relatively moderate in the remnants of radial glia near the dorsal neuroepithelium and focal expression of vimentin around vessels within the posterior horns. Expression of vimentin in the neuroepithelium of fetuses of 39-40 weeks was absent. In this age period, the neuroepithelium is structured from ependymocytes and radial glia cells are absent, as there is a relatively strong expression of S-100 in the neuroepithelium. Relatively strong expression of synaptophysin occurred in the posterior horns of 8-9 week fetuses. This age period is the beginning of the establishment of synaptic connections.
Morphological changes of sexually mature rat's pineal gland and cerebellar cortex under long-term exposure to heavy metal salts
Authors: Hryntsova N.B. , Romaniuk A.M. , Kiptenko L.I. , Sulym L.G. 
Published: December 2022

Pollution with heavy metal salts is an important environmental problem today, having an adverse effect on public health. The endocrine system maintains homeostasis in the body. The purpose of the work is to study the morphological changes of the cerebellar cortex and epiphyses of sexually mature male rats under the condition of long-term exposure to the body of a complex of heavy metal salts. The morphological changes in the cerebellar cortex and epiphysis of sexually mature male rats under the condition of long-term exposure to heavy metal salts was studied. Animals of the experimental group were simulated microelementosis by adding to drinking water a mixture of heavy metal salts for 60 days: zinc (ZnSO4×7H2O) – 5 mg/l, copper (CuSO4×5H2O) – 1 mg/l, iron (FeSO4) – 10 mg/l, manganese (MnSO4×5H2O) – 0.1 mg/l, lead (Pb(NO3)2) – 0.1 mg/l and chromium (K2Cr2O7) – 0.1 mg/l. Morphological, morphometric and statistical research methods were used. Long-term (60-days) intake of heavy metal salts mixture in the body of experimental animals leads to the development of the general adaptation syndrome, the stage of chronic stress “subcompensation” in the pineal gland. Morphological changes in the organs had a nonspecific polymorphic character, such as a sharp violation of hemodynamics, a violation of the morphology of the vascular wall, the state of pinealocytes and Purkinje cells, the development of tissue hypoxia, processes of apoptosis and reactive astrogliosis as a response to the action of a damaging agent. The pineal gland of the experimental animals showed signs of indole production, but the evacuation of hormones (including melatonin) into the vascular bed was hampered due to the violation of the morphology of the vascular wall and the cell membrane of pinealocytes. This led to a deficiency of this hormone in the body of the experimental animals, which negatively affected the adaptive processes in the cerebellar cortex in response to the action of the stress agent. Compensatory and adaptive processes in the pineal gland and cerebellar cortex had signs of functional stress. Adaptive processes were observed both in a small number of pinealocytes and in Purkinje cells, as well as an active adaptive glial reaction in both organs.
THE USE OF CONTENT LANGUAGE-INTEGRATED LEARNING AS THE MAIN MEANS OF FOREIGN LANGUAGE COMMUNICATION SKILLS FORMATION
Authors: Boichevska Ilona , Veremiuk Liudmyla 
Published: December 2022

The article is devoted to the analysis of modern methods of content-language-integrated learning (CLIL). The history of the emergence of this approach is considered, and the principles for the successful introduction of this technique are analyzed. The types of activities during the lessons where this approach to foreign language learning is applied are singled out. The advantages of the integrated training method are indicated, one of which is the formation of communicative competence. The content and organizational approach to the use of this technique is characterized. The authors elaborately substantiate the relevance, expediency and effectiveness of the application of content language-integrated learning of the English language, and also summarize the advantages and disadvantages of its use in English language teaching at a higher educational institution.
Keywords: CLIL methodology; content language-integrated learning; communicative competence; foreign language learning method; learning technology; future specialists; motivation; learning content; higher educational institution.
TRAINING OF FUTURE TECHNOLOGY TEACHERS TO NATIONAL PATRIOTIC EDUCATION OF SCHOOL STUDENTS IN THE CONDITIONS OF NUS
Authors: Kudrіa Oksana 
Published: December 2022

The article examines the problem of preparing future technology teachers for the national-patriotic education of schoolchildren in the conditions of the new Ukrainian school. It is proven that the national-patriotic education of youth in today's conditions is one of the most priority areas of work of educational institutions of Ukraine.The peculiarities of national-patriotic education of schoolchildren within technological education are analyzed. The potential possibilities of the content of labor training as an effective means of national-patriotic education are considered. It has been proven that the involvement of students in the achievements of Ukrainian national culture ensures the effective inclusion of the younger generation in the sphere of spiritual and material heritage of Ukrainians of the past. This contributes to the revival and preservation of the cultural heritage of the Ukrainian people, affects the formation of national self-The issue of the specifics of the educational and educational work of technology teachers in the conditions of the new Ukrainian school was considered. It was established that the qualitative implementation of the above depends on the national-patriotic identity of the teacher himself.The peculiarities of the national-patriotic education of students ‒ future technology teachers by means of the content of the relevant educational components are revealed. The experience of strengthening the national-patriotic views of student youth based on a set of measures of a theoretical and practical nature, which have a patriotic orientation and are relevant in todayʼs conditions, is highlighted. It has been established that future technology teachers who will work in a new Ukrainian school should be familiar with the scientific, theoretical and methodical principles of patriotic education of schoolchildren, possess techniques for including the issues of national and patriotic education of children in technological education, and introduce information about the acquisition of Ukrainianculture into the organizational structure classes in labor training lessons, to involve schoolchildren in social volunteering.
Key words: national education patriotic education; patriotism; national self-awareness; nationalpatriotic education; future teacher of technology; NUS; labor training; technology; national culture.
СЕЛЯНСЬКИЙ РУХ НА УМАНЩИНІ В РОКИ УКРАЇНСЬКОЇ РЕВОЛЮЦІЇ (1917-1920 РР.)
Authors: Дудник Олена 
Published: December 2022

В статті розглядають основні аспекти аграрної політики владних структур в роки Української революції (1917-1920 рр.). Аналізується причини, складові, масштаби розгортання селянського опору в Уманському повіті Київської губернії в період революційних процесів. Розглядається перебіг селянського руху на теренах Уманщини. Підкреслюється закономірність загальних тенденцій і увиразнюються особливості локального характеру. Матеріали представлені у статті доповнюють регіональну історію. Для дослідження означеної теми використана періодична преса тієї доби.