bluuebunny/crossref_metadata_2025_split huggingface dataset:
Physicochemical properties and behavior in
solution of three cellulases from haliotis fulgens
Authors: Rodrfguez-Romero Adela , Hernandez-Santoyo Alejandra , Rojo-Domfnguez Arturo , Garcfa-Hernandez Enrique 
Published: December 2022

Abstract:
Three proteins that showed activity over cellulosic substrates were isolated from the hepatopancreas of the blue abalone Haliotis fulgens. The purified cellulases are acidic with molecular weights between 17 900 and 30 300. Activity experiments indicated that they are endo-, exo- and l3-glucanases. These proteins form large aggregates as demonstrated by means of DLS experiments, which can be dissociated in the presence of polyethylene glycol and mannitol. The circular dichroism spectra in the far UV indicated that the enzymes belong to the 13-13 family.
Stability of a black eyed pea trypsin/chymotrypsin inhibitor (BTCI)
Authors: de Freitas Sonia Maria , Silva Luciano Paulino , Leite Jose Roberto S. A. , Bloch Jr. Carlos 
Published: December 2022

Abstract:
The stability of BTCI has been investigated as function of pH and temperature, following its inhibitory activity against trypsin. The isolated inhibitor of 9,084 Oa is stable over pH 3 to 12 at 25°C. BTCI showed high thermal stability ranging from 25 to 95°C at pH 3 and 7. However, the protein lost about 20% of its inhibitory activity over 75°C at pH 8.2. The results indicated that BTCI is extremely stable to heat and pH as typical of Bowman-Birk inhibitors.
Understanding the contribution of individual tryptophan residues to intrinsic lysozyme fluorescence
Authors: Uversky Vladimir N. , Kuznetsova Irina M. , Biktashev Alexander G. , Malova Lubov' N. , Bushmarina Natalia A. , Turoverov Konstantin K. 
Published: December 2022

Abstract:
Packing density and other properties of the microenvironment of tryptophan residues in hen egg-white lysozyme macromolecule have been studied on the basis of the known 3D structure of this protein. Results presented here suggest that the efficiency of action of the group which, in principal, can affect tryptophan fluor scence depends not only on the distance between this group and the indole ring, but to a great extent upon the location of this group relative to the indole ring.
Kesesuaian Lahan Potensial untuk Memanfaatkan Sisa Suplesi Bendungan Semantok di Kabupaten Nganjuk Provinsi Jawa Timur
Authors: Santosa Rizky Ramadhani Anwar , Sayekti Rini Wahyu , Siswoyo Hari 
Published: December 2022

The Semantok Dam was constructed in the Rejoso District of East Java's Nganjuk Regency to keep Â stable the water supply in Nganjuk Regency. There is frequently an 1,3 m3/s excess of supplementary water as determined by previous study. The objective of this study is to recalculate the excess of supplementary water based on the most recent hydrological conditions, using the calculation method for intake discharge at the Semantok Dam tower, calculating water irrigation needs, and calculating water loss in the canal, so that the value of excess of supplementary water can be used to develop the potential agricultural land. This research was conducted in the downstream of the Semantok Dam, precisely in 6 (six) Daerah Irigasi (D.I), namely D.I Rejoso, D.I Margomulyo, D.I Jatirejo, D.I Jati, D.I Janeng, and D.I Ngomben to calculate irrigation water needs. According to this study, if the Semantok Dam supplementation of 3.23 m3/s is combined with the predicted residual flow rate of 0.70 m3/s, a potential land area of 813 ha can be cultivated using the Paddy â€“ Paddy â€“ Paddy cropping pattern with a production profit of Rp. 42.119.578.800.Bendungan Semantok dibangun di Kecamatan Rejoso Kabupaten Nganjuk Jawa Timur untuk menjaga kestabilan pasokan air di Kabupaten Nganjuk. Permasalahan di lokasi penelitian sering terjadi kelebihan air pelengkap sebesar 1,3 m3/detik seperti yang ditentukan oleh penelitian sebelumnya. Tujuan dari penelitian ini adalah untuk menghitung ulang kelebihan air tampungan berdasarkan kondisi hidrologis terkini, menggunakan metode perhitungan debit intake di menara Bendungan Semantok, menghitung kebutuhan air irigasi, dan menghitung kehilangan air di sungai, sehingga nilainya kelebihan air tambahan dapat digunakan untuk mengembangkan potensi lahan pertanian. Penelitian ini dilakukan di bagian hilir Bendungan Semantok tepatnya di 6 (enam) Daerah Irigasi (D.I) yaitu D.I Rejoso, D.I Margomulyo, D.I Jatirejo, D.I Jati, D.I Janeng, dan D.I Ngomben untuk menghitung kebutuhan air irigasi. Dari penelitian ini diketahui bahwa kelebihan air dengan penambahan Bendungan Semantok sebesar 3,23 m3/detik dan debit sisa yang dihitung sebesar 0,70 m3/detik, direncanakan dapat mengembangkan potensi lahan seluas 813 ha dan mendapatkan keuntungan produksi sebesar Rp. 42.119.578.800 jika melakukan pola tanam Padi â€“ Padi â€“ Padi.
Studi Perbandingan Model Horton dan Model Kostiakov Terhadap Laju Infiltrasi
Authors: Prijanto Nisrina Amelia , Harisuseno Donny , Fidari Jadfan Sidqi 
Published: December 2022

Abstract: Lesti watershed, which is located in Malang Regency, is part of the Brantas sub-watershed. Lesti watershed has several problems such as land damage, and erosion that has an impact on infiltration rate. This studi aims to determine the infiltration rate using Horton Model and Kostiakov Model, so that the best model is obtained that approximates the measurement in the field by comparing it with empirical calculations as evidenced by using a model calibration test using the Nash-Sutcliffe Efficiency Test, Root Mean Square Error, Mean Absolute Error, and Relative Error. Infiltration rate data in the field was measured using a Double Ring Infiltrometer, then the data was analyzed using Horton and Kostiakov model empirical formulas. The results of the measurement of the highest initial infiltration rate(fo) at point 4 with a value of 15 mm/minute and the lowest fo value at point 12 with 4 mm/minute value. The results of empirical calculation of the highest value fo Horton model is 12.857 mm/minute at point 4, and Kostiakov is 9.215 at point 4. A calibration test is carried out between the infiltration rate of empirical formula with field calculations at 12 study points. Horton Model is shown to be close to infiltration rate measurement results are indicated by 4 calibration tests.Â Abstrak: DAS Lesti yang terletak pada Kabupaten Malang adalah bagian dari Sub-DAS Brantas. DAS Lesti memiliki beberapa permasalahan seperti kerusakan lahan, serta erosi yang berdampak terhadap laju infiltrasi. Studi ini bertujuan untuk mengetahui laju infiltrasi dengan Model Horton dan Model Kostiakov lalu diperoleh model terbaik yang mendekati pengukuran di lapangan dengan cara membandingkan dengan perhitungan empirisnya dibuktikan dengan menggunakan uji kalibrasi model menggunakan Uji Efisiensi Nash-Sutcliffe, Root Mean Square Error, Mean Absolute Error, dan Kesalahan Relatif. Data laju infiltrasi di lapangan diukur menggunakan alat Double Ring Infiltrometer, kemudian dari data tersebut dilakukan analisis menggunakan rumus empiris Model Horton dan Model Kostiakov. Hasil pengukuran laju infiltrasi awal (fo) tertinggi pada titik 4 dengan nilai sebesar 15 mm/menit dan nilai fo terendah pada titik 12 dengan nilai sebesar 4 mm/menit. Hasil perhitungan empiris nilai fo model Horton tertinggi sebesar 12,857 mm/menit pada titik 4, dan Kostiakov sebesar 9,215 pada titik 4. Setelah itu dilakukan uji kalibrasi antara laju infiltrasi rumus empiris dengan perhitungan di lapangan pada 12 titik studi, kemudian didapatkan Model Horton terbukti mendekati laju infiltrasi hasil pengukuran ditunjukkan oleh 4 uji kalibrasi.
Evaluasi Kualitas Air dan Sistem Hidran Pada Zona Pelayanan Betek Kota Malang Menggunakan Program WaterCAD
Authors: Hasibuan Fachry Rizaldy , Haribowo Riyanto , Wahyuni Sri 
Published: December 2022

The water need continues to be influenced by the rapidly growing population in an area, but this development is not accompanied by the availability of fresh water. PDAM (Municipal Water Supply Company) of Malang City consist ofÂ several Zones or DMA (District Meter Area), one of them is Betek Service Zone. the hydrant did not function properly, while the water quality was due to the Malang City hydrant being an integral part of the water distribution pipeline to the community. Evaluation of Water Quality and Hydrant System is based on the existing network condition in the Betek Service Zone where the Betek Reservoir water supply comes from the Tlogomas Reservoir from the Wendit Sources 1, 2 and 3. Betek Reservoir 1 flowing water by 101,189 liters/sec to DMA 1,2,4 and 5 and Betek Reservoir 2 of 233,339 liters/sec to DMA 3,6 and 7. Based on WaterCAD V8i software simulation in Betek Zone, the results of pressure, velocity, headloss gradient, and residual chlorine in existing and development conditions with the conditions of permitted pressure of 0.5-10 atm, permitted speed of 0.3-6 m/sec,Â permitted headloss gradient of 0-15 m/km and permittedÂ residual chlorine of 0.3-0.5 mg/l.Kebutuhan air yang terus dipengaruhi oleh pertumbuhan jumlah penduduk yang semakin pesat disuatu daerah, Tetapi perkembangan tersebut tidak diiringi dengan penyediaan air bersih yang ada. PDAM (Perusahaan Daerah Air Minum) Kota Malang menjadi beberapa Zona atau DMA (District Meter Area) salah satunya Zona Pelayanan Betek. Hidran sekitar Kota Malang tidak berfungsi dengan baik adapun kualitas air dikarenakan hidran Kota Malang menjadi satu kesatuan dengan pipa jaringan distribusi air ke masyarakat. Evaluasi Kualitas Air danÂ Sistem Hidran didasarkan pada jaringan kondisi eksisting di Zona Pelayanan Betek dimana suplai air Reservoir Betek berasal dari Reservoir Tlogomas yang berasal dari Sumber Wendit 1, 2 dan 3. Reservoir 1 Betek yang mengaliri air sebesar 101,189 ltr/dtk ke DMA 1,2,4 dan 5 dan Reservoir 2 Betek sebesar 233,339 ltr/dtk ke DMA 3,6 dan 7. Berdasarkan simulasi software WaterCAD V8i di Zona Betek didapatkan hasil tekanan, kecepatan, headloss gradient, dan sisa klorin pada kondisi eksisting dan pengembangan dengan syarat tekanan yang diijinkan 0,5-10 atm, kecepatan yang diijinkan 0,3-6 m/detik, headloss gradient yang diijinkan 0-15 m/km dan sisa klorin yang diijinkan 0,3-0,5 mg/l.
Relationship between nutritional status, lifestyle and prognosis in patients diagnosed with COVID-19 hospitalized in the state of Pernambuco
Authors: Silva Maria Bárbara Galdino , Pinho Claudia Porto Sabino , Barros Neto João de Araújo , Petribú Marina de Moraes Vasconcelos , Dourado Keila Fernandes , Maio Regiane 
Published: December 2022

Objective: To analyze the relationship between nutritional status and lifestyle habits and the prognosis of hospitalized patients with COVID-19 in Pernambuco. Methods: Multicenter, cross-sectional study, associated with prospective analysis variables, involving patients with COVID-19 and admitted to 8 hospitals. Individuals aged ≥ 18 years of both sexes, hospitalized from June 2020 to June 2021, were included. Socioeconomic, clinical, anthropometric, lifestyle and prognostic variables were collected. Results: The sample consisted of 263 individuals with a mean age of 62.9 ± 16.6 years and homogeneous distribution between genders. It was observed that 8.2% were smokers, 20.9% reported alcohol consumption, and 80.1% were sedentary. The anthropometric profile indicated that 49.5% were overweight and 7.0% were underweight. Malnutrition and excess weight were associated with more extended hospital stays (66.7% weight loss and 64.5% weight gain vs. 30.0% eutrophy; p = 0.021), smoking with death (tab 65 .0% vs. non-tab 33.7%; p = 0.006) and need for admission to the intensive care unit (yes 64.3%, no 31.5%; p = 0.014). The frequency of dyspnea was higher in patients who reported drinking alcohol (yes 69.6% vs. no 48.1%; p = 0.007). Physical activity was not associated with any prognostic factor. Conclusion: Nutritional extremes and bad lifestyle habits, such as smoking and alcohol consumption, are risk factors for a poor prognosis in individuals with COVID-19.
Effects of omega-3 supplementation associated with physical activity in obese patients with type 2 diabetes mellitus: study protocol
Authors: Cardoso de Lima Mário Flávio , Fraga Lopes Marina Guedes , Justo Neto Wellington Henrique , De Souza Cláudio Teodoro 
Published: December 2022

Objective: This study aims to evaluate the effects of omega-3-rich fish oil supplementation with or without physical activity on anti-inflammatory and insulin resistance parameters in obese and type 2 diabetic individuals. Methods: Randomized, double-blind intervention study of omega-3. Adults with obesity and type 2 diabetes mellitus on exclusive use of metformin as a drug to control blood glucose will be included. The Protocol will be based on clinical and nutritional follow-up (supplementation with omega-3) and remote physical activity for eight weeks. Individuals selected for the study will be randomly assigned to one of the following groups: i) omega-3; ii) omega-3 + physical activity; iii) physical activity + placebo; iv) placebo. To analyze the results, biochemical parameters (fasting glucose and insulin, glycosylated hemoglobin, liver enzymes, urea, creatinine, total cholesterol and fractions, triglycerides, CRP, and ferritin) and inflammatory parameters (TNF alpha, IL-1 beta, IL- 6 and IL-10). At the end of the study, it is expected that the intervention associated with omega-3 in the physical activity protocol will promote a reduction in parameters related to insulin resistance, levels of inflammatory cytokines, and anthropometric parameters.
Aplicaciones de la gestión del conocimiento de los productores en la tipología de sistemas productivos ovinos y caprinos
Authors: Moreno Vargas Diana Cristina , Grajales Lombana Henry Alberto 
Published: December 2022

La tipología de los sistemas ovinos y caprinos varía de acuerdo con el estado del conocimiento tácito y explícito de los productores. Los objetivos de la investigación fueron analizar las nuevas tendencias y aplicaciones de los Sistemas Basados en el Conocimiento para el apoyo a la gestión en la producción animal y caracterizar los sistemas de producción de ovinos y caprinos con base en el proceso de gestión del conocimiento. Las tipologías se utilizan como herramientas para dilucidar la variabilidad de las características de las granjas y de los productores. El enfoque metodológico integró: a) la elaboración de un modelo conceptual que tiene como conexión central el conocimiento tácito y el explícito, b) el análisis bibliográfico del sistema de apoyo a la gestión en la producción animal basado en el conocimiento y del dominio del conocimiento de los ganaderos, y c) las categorías de conocimiento obtenidas por los ganaderos según el objetivo de producción y su nivel tecnológico en la zona de estudio. La metodología SIGETEC ha permitido definir los niveles tecnológicos y las intervenciones de desarrollo al utilizar los modelos adecuados para cada escala tecnológica. La tipología de sistemas basada en el conocimiento puede estructurarse en torno a cinco dimensiones: asistencia técnica, sistemas de pastoreo rotacional, tipo de apareamiento, sistema de registro y control implementado y toma de decisiones. Por lo tanto, el modelo tipológico propuesto ha captado las principales tendencias dentro de la escala de los cambios tecnológicos afectados por el nivel de expresión del conocimiento de los productores ovinos y caprinos. Se concluye que la nueva tipología es útil desde el punto de vista analítico para mejorar los sistemas de conocimiento de los productores y podría ser una herramienta operativa y de desarrollo para los productores, profesionales e investigadores.
Ontologies Applied in Clinical Decision Support System Rules: Systematic Review
Authors: Jing Xia , Min Hua , Gong Yang , Biondich Paul , Robinson David , Law Timothy , Nohr Christian , Faxvaag Arild , Rennert Lior , Hubig Nina , Gimbel Ronald 
Published: December 2022

Background
Clinical decision support systems (CDSSs) are important for the quality and safety of health care delivery. Although CDSS rules guide CDSS behavior, they are not routinely shared and reused.

Objective
Ontologies have the potential to promote the reuse of CDSS rules. Therefore, we systematically screened the literature to elaborate on the current status of ontologies applied in CDSS rules, such as rule management, which uses captured CDSS rule usage data and user feedback data to tailor CDSS services to be more accurate, and maintenance, which updates CDSS rules. Through this systematic literature review, we aim to identify the frontiers of ontologies used in CDSS rules.

Methods
The literature search was focused on the intersection of ontologies; clinical decision support; and rules in PubMed, the Association for Computing Machinery (ACM) Digital Library, and the Nursing & Allied Health Database. Grounded theory and PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) 2020 guidelines were followed. One author initiated the screening and literature review, while 2 authors validated the processes and results independently. The inclusion and exclusion criteria were developed and refined iteratively.

Results
CDSSs were primarily used to manage chronic conditions, alerts for medication prescriptions, reminders for immunizations and preventive services, diagnoses, and treatment recommendations among 81 included publications. The CDSS rules were presented in Semantic Web Rule Language, Jess, or Jena formats. Despite the fact that ontologies have been used to provide medical knowledge, CDSS rules, and terminologies, they have not been used in CDSS rule management or to facilitate the reuse of CDSS rules.

Conclusions
Ontologies have been used to organize and represent medical knowledge, controlled vocabularies, and the content of CDSS rules. So far, there has been little reuse of CDSS rules. More work is needed to improve the reusability and interoperability of CDSS rules. This review identified and described the ontologies that, despite their limitations, enable Semantic Web technologies and their applications in CDSS rules.
Plain language summary: Clinical study of BI 1015550 as a potential treatment for idiopathic pulmonary fibrosis
Authors: Richeldi Luca , Azuma Arata , Cottin Vincent , Hesslinger Christian , Stowasser Susanne , Valenzuela Claudia , Wijsenbeek Marlies S , Zoz Donald F , Voss Florian , Maher Toby M 
Published: December 2022

What is this summary about?

This plain language summary describes the main findings from a trial in people with idiopathic pulmonary fibrosis (also called IPF) that was recently published in the
New England Journal of Medicine
. IPF is a rare disease, where the lungs become more and more scarred, with breathing and oxygen uptake becoming increasingly difficult. This trial looked at the medication BI 1015550 as a potential treatment for IPF. It compared BI 1015550 to placebo (a dummy drug that does not contain any active ingredients) to investigate the effectiveness of the drug in treating people with IPF. The study also looked at the additional medical issues (referred to as adverse events) reported during the study. Some participants took approved treatments to reduce scarring (nintedanib or pirfenidone), and some did not.

What were the results?
Overall, 147 people with IPF from 22 countries took part in the trial. The results showed that BI 1015550 prevented lung function from decreasing in people with IPF. There was no difference in the percentage of patients with medical issues rated as severe by the study physician with BI 1015550 or placebo. However, more people treated with BI 1015550 had diarrhoea. Among those treated with BI 1015550, 13 participants stopped their treatment due to medical issues, whereas treatment was not stopped due to medical issues for any participants treated with placebo.

What do the results mean?
These results provide evidence that BI 1015550 prevents lung function from worsening in people with IPF. Further clinical studies will be conducted in the future to test BI 1015550 in a larger group of people with IPF and other forms of lung scarring that get worse over time, and for a longer time period.
Peran dan Gagasan Susilo Bambang Yudhoyono dalam Resolusi Konflik Aceh
Authors: Supriadi Supriadi , Nirzalin Nirzalin , Mursyidin Mursyidin 
Published: December 2022

The Aceh peace achieved in 2005 has become an example for the international community in resolving conflicts using a dialogue approach. Of course, it cannot be separated from the role and ideas of Susilo Bambang Yudhoyono as the president of the Republic of Indonesia at that time. This article aims to describe SBY's role and ideas in Aceh's conflict resolution context. The data in this study are sourced from relevant literature studies and analyzed with a qualitative approach. This study shows that several basic things are important points in the context of SBY's role and ideas in pursuing peace in Aceh. First, peace efforts are based on sincerity and political commitment to end the conflict. Second, the ability to see difficulties during a tsunami becomes an opportunity for peace. Third, the choice of a non-militaristic approach and relying on dialogue. Fourth, courage in taking risks and realizing measurable policies in pursuing peace in Aceh. Apart from that, the commitment to peace from the government and GAM is an important point in the realization of peace in Aceh because the commitment to peace by complying with the points of the agreement has been agreed upon and makes peace continue.
Abstrak
Perdamaian Aceh yang berhasil diraih pada tahun 2005 telah menjadi contoh bagi dunia internasional tentang bagaimana menyelesaikan konflik bersenjata dengan pendekatan dialog. Hal ini tentunya tidak terlepas dari peran dan gagasan Susilo Bambang Yudhoyono yang kala itu menjadi presiden Republik Indonesia. Dengan menggunakan pendekatan kualitatif, artikel ini bertujuan untuk mendeskripsikan lebih lanjut tentang peran dan gagasan SBY dalam konteks resolusi konflik di Aceh Data dalam penelitian ini bersumber dari kajian-kajian literatur yang relevan. Kajian ini menunjukkan bahwa terdapat beberapa hal mendasar yang menjadi poin penting dalam konteks peran dan gagasan SBY dalam mengupayakan perdamaian Aceh. Pertama, upaya perdamaian yang di dasarkan pada kesungguhan dan komitmen politik untuk benar-benar mengakhiri konflik. Kedua, kemampuan dalam melihat kesulitan di tengah tsunami menjadi peluang untuk berdamai. Ketiga, pilihan pendekatan non militeristik dan bertumpu pada dialog. Keempat, keberanian dalam mengambil risiko dan realisasi kebijakan yang terukur dalam mengupayakan perdamaian di Aceh. Terlepas pada itu, komitmen perdamaian dari pemerintah dan GAM menjadi poin penting dari realisasi perdamaian Aceh, karena komitmen damai dengan cara mematuhi poin-poin perjanjian yang telah disepakati membuat perdamaian dapat terus bertahan.