bluuebunny/crossref_metadata_2025_split huggingface dataset:
Novel Google Maps and Google Earth application for chemical industry disaster risk assessment during complex emergencies in Eastern Ukraine
Authors: Gan Rick Kye , Bruni Emanuele , Castro Delgado Rafael , Alsua Carlos , Arcos González Pedro 
Published: April 2023

AbstractThe war in Ukraine has led to complex emergencies, humanitarian crises, and other severe consequences, such as chemical industry disasters. The chemical industry is one of the principal sectors of Ukraine’s economy. In 2019, Ukraine had a total volume of hazardous chemical accumulation of more than a 5.1billion tons. Therefore, an attack on chemical industrial facilities will lead to catastrophic consequences such as chemical disasters. This paper aims to study the disaster risk of chemical industrial facilities and its effects on public health and the environment during complex emergencies in Eastern Ukraine. Observational cross-sectional risk assessment method was utilized to assess hazard, vulnerability, and exposure of the chemical industry in Eastern Ukraine in Donetsk Oblast and Luhansk Oblast. Data on chemical factories in Eastern Ukraine was collected on Google Maps and Google Earth on May 2022. Lastly, the semi-quantitative risk assessment method was utilized to describe the risk from the perspective of consequences for life and health, the environment, property, and speed of development. Our disaster risk assessment found more than 1 million people (1,187,240 people) in Donetsk Oblast and more than 350 thousand people (353,716 people) in Luhansk Oblast are exposed to potential hazards from the chemical facilities clusters. The aggregation risk of bombardment of chemical facilities cluster in Eastern Ukraine is also high due to ongoing war. Therefore, the chemical industry disaster risks for Eastern Ukraine during complex emergencies in Donetsk Oblast and Luhansk Oblast are high in terms of likelihood and consequences to life and health, environment, property, and speed of development.
Response of varied rice genotypes on cell membrane stability, defense system, physio-morphological traits and yield under transplanting and aerobic cultivation
Authors: Zayed Bassiouni A. , Ghazy Hasnaa A. , Negm Mahrous E. , Bassiouni Sherif M. , Hadifa Adel A. , El-Sharnobi Dalia E. , Abdelhamed Mohamed M. , Abo-Marzoka Elsayed A. , Okasha Amira M. , Elsayed Salah , Farooque Aitazaz A. , Yaseen Zaher Mundher 
Published: April 2023

AbstractAerobic rice cultivation progresses water productivity, and it can save almost 50% of irrigation water compared to lowland rice with the appropriate development of genotypes and management practices. Two field trials were conducted during 2020, and 2021 seasons to determine the validation of different rice varieties under aerobic cultivation based on their plant defense system, physio-morphological traits, stress indices, grain yield, and water productivity. The experiments were designed in a split-plot design with four replications. Two planting methods, transplanting and aerobic cultivation, were denoted as the main plots, and ten rice genotypes were distributed in the subplots. The results revealed that the planting method varied significantly in all measured parameters. The transplanting method with well watering had the highest value of all measured parameters except leaf rolling, membrane stability index, antioxidant, proline, and the number of unfilled grains. EHR1, Giza179 and GZ9399 as well as A22 genotypes a chief more antioxidant defense system that operated under aerobic conditions. Giza179, EHR1, GZ9399, and Giza178 showed high cell membrane stability and subsequently high validation under such conditions, and also showed efficiency in decreasing water consumption and improving water use efficiency. In conclusion, this study proves that Giza179, EHR1, GZ9399, Giza178, and A22 are valid genotypes for aerobic conditions.
Electrophysiological, emotional and behavioural responses of female targets of sexual objectification
Authors: Monachesi Bianca , Deruti Alice , Grecucci Alessandro , Vaes Jeroen 
Published: April 2023

AbstractSexual objectification and the interiorized objectifying gaze (self-objectification) are dangerous phenomena for women’s psychological wellness. However, their specific effects on women’s socio-affective reactions are still poorly understood, and their neural activity has never been explored before. In the present study, we investigated women’s emotional and electrophysiological responses during simulated computer-based objectifying social interactions, and we examined consequent punishing behaviours towards the perpetrator using the ultimatum game. Behavioural results (N = 36) showed that during objectifying encounters women generally felt angrier/disgusted and tended to punish the perpetrator in later interactions. However, the more the women self-objectified, the more they felt ashamed (p = 0.011) and tended to punish the perpetrators less (p = 0.008). At a neural level (N = 32), objectifying interactions modulated female participants’ neural signal elicited during the processing of the perpetrator, increasing early (N170) and later (EPN, LPP) ERP components. In addition, only the amplitude of the LPP positively correlated with shame (p = 0.006) and the level of self-objectification (p = 0.018). This finding provides first evidence for the specific time-course of sexual objectification, self-objectification and its associated shame response, and proves that emotional and social consequences of sexual objectification in women may depend on their tendency to self-objectify.
First continuous marine sponge cell line established
Authors: Hesp Kylie , van der Heijden Jans M. E. , Munroe Stephanie , Sipkema Detmer , Martens Dirk E. , Wijffels Rene H. , Pomponi Shirley A. 
Published: April 2023

AbstractThe potential of sponge-derived chemicals for pharmaceutical applications remains largely unexploited due to limited available biomass. Although many have attempted to culture marine sponge cells in vitro to create a scalable production platform for such biopharmaceuticals, these efforts have been mostly unsuccessful. We recently showed that Geodia barretti sponge cells could divide rapidly in M1 medium. In this study we established the first continuous marine sponge cell line, originating from G. barretti. G. barretti cells cultured in OpM1 medium, a modification of M1, grew more rapidly and to a higher density than in M1. Cells in OpM1 reached 1.74 population doublings after 30 min, more than twofold higher than the already rapid growth rate of 0.74 population doublings in 30 min in M1. The maximum number of population doublings increased from 5 doublings in M1 to at least 98 doublings in OpM1. Subcultured cells could be cryopreserved and used to inoculate new cultures. With these results, we have overcome a major obstacle that has blocked the path to producing biopharmaceuticals with sponge cells at industrial scale for decades.
Ablation of TRPC3 disrupts Ca2+ signaling in salivary ductal cells and promotes sialolithiasis
Authors: Choi Bok-Eum , Shin Samuel , Evans Sade , Singh Brij B. , Bandyopadhyay Bidhan C. 
Published: April 2023

AbstractClinical studies and structural analyses of salivary stones strongly suggest a linkage between higher saliva calcium (Ca2+) and salivary stone formation, sialolithiasis; however, the process and the mechanism leading to Ca2+ overload during sialolithiasis is not well understood. Here, we show that TRPC3 null (−/−) mice presented with a reduction in Ca2+ entry and current in ductal cells with higher saliva [Ca2+] suggesting diminished transepithelial Ca2+ flux across the salivary ductal cells, leaving more Ca2+ in ductal fluid. Significantly, we found that TRPC3 was expressed in mice and human salivary ductal cells, while intraductal stones were detected in both mice (TRPC3−/−) and patient (sialolithiasis) salivary glands. To identify the mechanism, we found that TRPC3 was crucial in preventing the expression of calcification genes (BMP2/6, Runx2) in ductal cells which may be due to higher extracellular Ca2+ in SMG tissues. Similarly, inflammatory (IL6, NLRP3), fibrotic (FN1, TGFβ1) and apoptotic (Bax1/Bcl2) markers were also elevated, suggesting that the loss of TRPC3 induces genetic changes that leads to salivary gland cell death and induction of inflammatory response. Overall, ablation of TRPC3−/− leads to higher saliva [Ca2+], along with elevated detrimental gene expressions, altogether contributing to salivary gland stone formation.
A moderated mediation analysis of the association between smoking and suicide attempts among adolescents in 28 countries
Authors: Peprah Prince , Asare Bernard Yeboah-Asiamah , Okwei Reforce , Agyemang-Duah Williams , Osafo Joseph , Kretchy Irene A. , Gyasi Razak M. 
Published: April 2023

AbstractGlobally, evidence has shown that many adolescents are victims of substance use, mainly cigarette smoking, and it has been associated with suicidal ideation. However, the mechanisms underlying this association are poorly understood. This study examines whether truancy mediates and gender moderates the association of cigarette smoking with suicide attempts among adolescents in 28 countries. Data from the Global School-Based Student Health Survey were used. Hierarchical multiple logistic regression analyses were used to estimate the effect-modification of gender on cigarette smoking and suicide attempt. The mediating effect of truancy on the association between cigarette smoking and suicidal attempt was assessed using the generalized decomposition method. Cigarette smoking was associated with suicide attempts after adjusting for several confounding variables (aOR = 1.21; 95% CI = 1.09–1.33). The bootstrap results from the generalized decomposition analysis indicated that truancy partially mediated the association of cigarette smoking with a suicide attempt, contributing 21% of the total effect among in-school adolescents. Hierarchical regression analyses suggested that gender moderated the effect of cigarette smoking on suicidal attempts: female adolescents who smoked had 36% higher odds of suicidal attempts compared to male adolescents. The findings suggest possible pathways for designing and implementing interventions to address adolescents' cigarette smoking and truancy to prevent suicidal attempts.
Electron–phonon interaction toward engineering carrier mobility of periodic edge structured graphene nanoribbons
Authors: Hsu Teng-Chin , Wu Bi-Xian , Lin Rong-Teng , Chien Chia-Jen , Yeh Chien-Yu , Chang Tzu-Hsuan 
Published: April 2023

AbstractGraphene nanoribbons have many extraordinary electrical properties and are the candidates for semiconductor industry. In this research, we propose a design of Coved GNRs with periodic structure ranged from 4 to 8 nm or more, of which the size is within practical feature sizes by advanced lithography tools. The carrier transport properties of Coved GNRs with the periodic coved shape are designed to break the localized electronic state and reducing electron–phonon scattering. In this way, the mobility of Coved GNRs can be enhanced by orders compared with the zigzag GNRs in same width. Moreover, in contrast to occasional zero bandgap transition of armchair and zigzag GNRs without precision control in atomic level, the Coved GNRs with periodic edge structures can exclude the zero bandgap conditions, which makes practical the mass production process. The designed Coved-GNRs is fabricated over the Germanium (110) substrate where the graphene can be prepared in the single-crystalline and single-oriented formants and the edge of GNRs is later repaired under "balanced condition growth" and we demonstrate that the propose coved structures are compatible to current fabrication facility.
Live 4D-OCT denoising with self-supervised deep learning
Authors: Nienhaus Jonas , Matten Philipp , Britten Anja , Scherer Julius , Höck Eva , Freytag Alexander , Drexler Wolfgang , Leitgeb Rainer A. , Schlegl Thomas , Schmoll Tilman 
Published: April 2023

AbstractBy providing three-dimensional visualization of tissues and instruments at high resolution, live volumetric optical coherence tomography (4D-OCT) has the potential to revolutionize ophthalmic surgery. However, the necessary imaging speed is accompanied by increased noise levels. A high data rate and the requirement for minimal latency impose major limitations for real-time noise reduction. In this work, we propose a low complexity neural network for denoising, directly incorporated into the image reconstruction pipeline of a microscope-integrated 4D-OCT prototype with an A-scan rate of 1.2 MHz. For this purpose, we trained a blind-spot network on unpaired OCT images using a self-supervised learning approach. With an optimized U-Net, only a few milliseconds of additional latency were introduced. Simultaneously, these architectural adaptations improved the numerical denoising performance compared to the basic setup, outperforming non-local filtering algorithms. Layers and edges of anatomical structures in B-scans were better preserved than with Gaussian filtering despite comparable processing time. By comparing scenes with and without denoising employed, we show that neural networks can be used to improve visual appearance of volumetric renderings in real time. Enhancing the rendering quality is an important step for the clinical acceptance and translation of 4D-OCT as an intra-surgical guidance tool.
Unveiling the paths of COVID-19 in a large city based on public transportation data
Authors: Araújo Jorge L. B. , Oliveira Erneson A. , Lima Neto Antonio S. , Andrade José S. , Furtado Vasco 
Published: April 2023

AbstractHuman mobility plays a key role in the dissemination of infectious diseases around the world. However, the complexity introduced by commuting patterns in the daily life of cities makes such a role unclear, especially at the intracity scale. Here, we propose a multiplex network fed with 9 months of mobility data with more than 107 million public bus validations in order to understand the relation between urban mobility and the spreading of COVID-19 within a large city, namely, Fortaleza in the northeast of Brazil. Our results suggest that the shortest bus rides in Fortaleza, measured in the number of daily rides among all neighborhoods, decreased$$\approx 25$$≈25% more than the longest ones after an epidemic wave. Such a result is the opposite of what has been observed at the intercity scale. We also find that mobility changes among the neighborhoods are synchronous and geographically homogeneous. Furthermore, we find that the most central neighborhoods in mobility are the first targets for infectious disease outbreaks, which is quantified here in terms of the positive linear relation between the disease arrival time and the average of the closeness centrality ranking. These central neighborhoods are also the top neighborhoods in the number of reported cases at the end of an epidemic wave as indicated by the exponential decay behavior of the disease arrival time in relation to the number of accumulated reported cases with decay constant$$\lambda \approx 33$$λ≈33days. We believe that these results can help in the development of new strategies to impose restriction measures in the cities guiding decision-makers with smart actions in public health policies, as well as supporting future research on urban mobility and epidemiology.
Pyrazole-sulfonamide scaffold featuring dual-tail strategy as apoptosis inducers in colon cancer
Authors: El-Hazek Reham M. M. , Zaher Nashwa H. , Emam Hagar E. S. , El-Gazzar Marwa G. , Khalil Amira 
Published: April 2023

AbstractDual-tail strategy has been successfully utilized in the development of novel carbonic anhydrase IX (CA IX) inhibitors. Herein we adopted this approach in the design and synthesis of a series of novel pyridine sulfonamide-pyrazole hybrid scaffold mimicking dual-tail inhibitors of CA IX. A library of 15 compounds was synthesized and assessed for their potential cytotoxic effects against colorectal cancer cells. Compounds 3, and 11 induced potential cytotoxic effects against the three cancer cell lines (HCT-116, HT-29, and SW-620) with IC50s’ of 45.88, 28.27, and 16.57 uM, 25.01, 8.99, and 3.27 µM, respectively. Both compounds induced cellular apoptosis on HCT-116 and SW-620 cells, while compound 3 induced necrosis as well. In addition, both compounds induced cell cycle arrest on G0/G1, and S phases. Also, compound 11 showed potential autophagy induction on both colon cancer cell lines (HCT-116, and HT-29), and a little bit on metastatic type. Both compounds were less cytotoxic than the reference drug on normal epithelial cell. The migration rates of HCT-116 and the metastatic one SW-620 were reduced by both compounds. Finally, molecular docking of compounds 3 and 11 into the active site of CA IX confirmed in vitro inhibitory activity for both compounds.
Measurement and simulation of irrigation performance in continuous and surge furrow irrigation using WinSRFR and SIRMOD models
Authors: Radmanesh Mojgan , Ahmadi Seyed Hamid , Sepaskhah Ali Reza 
Published: April 2023

AbstractThe SIRMOD and WinSRFR models were used to model and assess the irrigation performance under continuous and surge irrigation strategies with two furrow lengths of 70 m and 90 m and stream sizes of 0.4 l/s and 0.6 l/s for each length. According to the normalized root mean squared error (NRMSE) and the relative error (RE), WinSRFR had, on average, excellent accuracy in the continuous and surge irrigation for simulating advance-recession times (NRMSE: 6.15 and 4.24% for advance time, and 2.20 and 5.20% for recession time), infiltrated water depth (NRMSE: 3.37 and 6.38%), and runoff volume (RE: 6.93 and 2.57%), respectively. SIRMOD had also, on average, excellent simulation in the continuous and surge irrigation for advance-recession times (NRMSE: 3.34 and 2.45% for advance time, and 2.28 and 6.41% for recession time), infiltrated water depth (NRMSE: 2.98 and 5.27%), and runoff volume (RE: 5.31 and 17.49%), respectively. The average of irrigation application efficiency (AE), distribution uniformity (DU), deep percolation (DP), and tail-water ratio (TWR) were 61.50, 90.25, 11.75, and 26.75% in continuous irrigation, and 72.03, 94.09, 8.39, and 19.57% in surge irrigation, respectively, which shows that surge irrigation increased AE (irrigation management performance) and DU (irrigation method performance) and reduced DP and TWR compared to continuous irrigation. Moreover, longer furrow lengths increased AE and DP under both irrigation methods, while it decreased TWR and DU. However, increasing the stream size decreased AE and DP and increased TWR under both continuous and surge irrigations. The higher stream size improved DU in continuous irrigation but reduced DU in surge irrigation. The results confirmed that both SIRMOD and WinSRFR are reliable analytical tools to evaluate furrow irrigation strategies for improving irrigation management. In conclusion, this study showed that surface irrigation models could be employed in practice by irrigation engineers and practitioners to design and define the optimized furrow length and stream size in arid and semi-arid areas where efficient and high performance irrigation strategies are required to save water and reduce water loss.
Calibrating contact parameters of typical rotary tillage components cutting soil based on different simulation methods
Authors: Zhang Xiongye , Zhang Lixin , Hu Xue , Wang Huan , Shi Xuebin 
Published: April 2023

AbstractThis report analyzes the problem of complex soil movement patterns under the action of coupled forces, such as tension and shear, in agricultural processes and aims to improve the accuracy of contact parameters used in discrete element simulation studies of rototiller-soil interactions. This study focuses on the soil of Shihezi cotton field in the 8th division of Xinjiang and investigates the rotating tiller roller as a soil-touching component of tillage machinery. A combination of simulations and physical testing is used. We perform angle of repose tests and use edge detection, fitting, and other image processing methods to automatically, quickly, and accurately detect the soil accumulation and angle calibration of the contact parameters with soil particles. Additionally, soil slip tests are conducted to calibrate the contact parameters between the soil and the rotary blades. Optimization is achieved based on orthogonal simulations and the Box-Behnken response surface method using physically measured values as the target. A regression model of the stacking angle and rolling friction angle is established to determine the optimal combination of simulation contact parameters: between soil and soil, the recovery coefficient is 0.402, static friction coefficient is 0.621, and rolling friction coefficient is 0.078; between soil contact parts and soil, the recovery coefficient is 0.508, static friction coefficient is 0.401, and rolling friction coefficient is 0.2. Furthermore, the calibration parameters are selected as contact parameters for the discrete element simulation. By combining the above two simulation methods to analyze and compare the simulation process of cutting soil from rototiller roller parts to rototiller single blade parts, we obtained the changes in energy, cutting resistance, and soil particle movement at different depths of the soil cutting process. Finally, the average cutting resistance was used as an index for validation in the field tests. The measured value is 0.96 kN and the error of the discrete element simulation is 13%. This demonstrates the validity of the calibrated contact parameters and the accuracy of the simulation, which can provide a theoretical reference and technical support for the study of the interaction mechanisms between of tillage equipment parts and soil, as well as the design and optimization of these interactions in the future.
Social aspects of collision avoidance: a detailed analysis of two-person groups and individual pedestrians
Authors: Gregorj Adrien , Yücel Zeynep , Zanlungo Francesco , Feliciani Claudio , Kanda Takayuki 
Published: April 2023

AbstractPedestrian groups are commonly found in crowds but research on their social aspects is comparatively lacking. To fill that void in literature, we study the dynamics of collision avoidance between pedestrian groups (in particular dyads) and individual pedestrians in an ecological environment, focusing in particular on (i) how such avoidance depends on the group’s social relation (e.g. colleagues, couples, friends or families) and (ii) its intensity of social interaction (indicated by conversation, gaze exchange, gestures etc). By analyzing relative collision avoidance in the “center of mass” frame, we were able to quantify how much groups and individuals avoid each other with respect to the aforementioned properties of the group. A mathematical representation using a potential energy function is proposed to model avoidance and it is shown to provide a fair approximation to the empirical observations. We also studied the probability that the individuals disrupt the group by “passing through it” (termed as intrusion). We analyzed the dependence of the parameters of the avoidance model and of the probability of intrusion on groups’ social relation and intensity of interaction. We confirmed that the stronger social bonding or interaction intensity is, the more prominent collision avoidance turns out. We also confirmed that the probability of intrusion is a decreasing function of interaction intensity and strength of social bonding. Our results suggest that such variability should be accounted for in models and crowd management in general. Namely, public spaces with strongly bonded groups (e.g. a family-oriented amusement park) may require a different approach compared to public spaces with loosely bonded groups (e.g. a business-oriented trade fair).