bluuebunny/crossref_metadata_2025_split huggingface dataset:
Electromagnetic transition strengths on the S-factor for radiative capture proton by 17O
Authors: Dalvand Massoumeh , Khalili Hassan 
Published: March 2023

Abstract
The study of the astrophysical S-factor is essential in the analysis of low-temperature stellar radioactive capturing reactions in theoretical frameworks. We investigate the proton capture by 17O using Wood Saxon potential model. We calculated the astrophysical S-factor for 17O(p, γ) 18F reactions at low energy. In the hydrogen-burning process, this reaction plays a role in multiple stages of stellar evolution. Furthermore, it is important in the synthesis of fluorine and oxygen isotopes, which is part of the CNO cycle. At low energis, the empirical size of the cross-section of this reaction is not available. As a result, the reaction rate could be used in theoretical models by extrapolating the astrophysical S-factor to extremely low energy levels and finding the cross-section. Finally, transition strengths on the astrophysical S-factor is calculated and it was found that electric dipole(E1) transition in the 500 keV energy range is dominant. The findings are consistent with empirical data and other theoretical models. Furthermore, the S-factor at zeri energy for the (5/2)+ level was calculated using extrapolation, yielding S(0)= 4.807 keV.b .
The influence of permeability and heterogeneity on water flooding–chemical flooding efficiency and remaining oil distribution ——Based on nuclear magnetic resonance displacement imaging
Authors: Zhang Yang , Gai Changcheng , Song Binghui , Jiang Jiguo , Wang Zhiqiang 
Published: March 2023

Abstract
To clarify the impact of permeability and heterogeneity on oil displacement efficiency and remaining oil distribution of water flooding-chemical flooding, three groups of high and ultrahigh permeability core samples from an ultrahigh water-cut oilfield in western China were selected as the research objects in this study. High-pressure mercury injection, scanning electron microscopy, wettability test, and other methods were used to characterize the reservoir properties of core samples. Six groups of experiments were performed using the nuclear magnetic resonance (NMR) displacement imaging technology to simulate the oilfield development process considering the economic benefits, and the oil displacement efficiency and remaining oil distribution characteristics of water flooding combined with polymer flooding and polymer-surfactant flooding in reservoirs with varying physical properties were discussed. The research shows that during the simulation process of first water flooding followed by chemical flooding and then water flooding in the oilfield, the T2 spectrum signal amplitude increases the most in the two stages, one is from saturated oil flooding to 50% water cut and the other one is from 95% water cut to the end of 1 PV polymer flooding. The oil displacement efficiency increases the most, and the oil is primarily discharged from pore throats larger than 90 ms (or with pore throat radius of 8.37 µm). Higher permeability and the addition of surfactant based on the polymer are beneficial in improving final oil displacement efficiency, and the displacement efficiency is better when the polymer-surfactant binary flooding acts on the reservoir with higher permeability. The fingering phenomenon and remaining oil distribution are controlled by reservoir heterogeneity and gravity: the lower the heterogeneity, the more uniform the remaining oil distribution, and the closer the oil saturation at the experiment’s inlet and outlet. The more heterogeneous the sample, the more obvious is the fingering phenomenon, and the remaining oil is primarily distributed at the outlet end as well as at the top of the sample. The study results provide theoretical guidance for tapping the remaining oil potential of old oilfields with high to ultrahigh permeabilities.
A Circular Split Ring Resonator Absorber with Graphene Material for Terahertz Communication Applications
Authors: Prasad Nagandla , P Pardhasaradhi , Madhav B.T.P. , Das Sudipta , Rao M C 
Published: March 2023

Abstract
In this research article, we proposed a split ring resonator(SRR) based metasurface absorber based on graphene material. The performance of the graphene-based absorber at terahertz frequencies can be altered by varying the chemical potential of graphene material. Because of its excellent tunability and optical responsiveness at terahertz frequency, graphene-based metamaterials have been widely used in optoelectronic devices, sensors, filters, and many more. The proposed structure contains three layers namely graphene-based patch a conductive layer, lossy silicon as a dielectric layer, and finally gold as a bottom conductive layer. The purpose of this research is to present a thorough investigation of graphene-based THz metamaterial absorbers, including modeling and verification of the structure through an equivalent circuit approach. It is very much beneficial to understand the conductive phenomenon of graphene material by tuning the fermi chemical potential.
Accuracy of smartphone application to quantify jaundice in neonates: A systematic review with meta-analysis
Authors: Hegde Deeparaj , Rath Chandra , Amarasekara Sathika , Saraswati Chitra , Patole Sanjay , Rao Shripada 
Published: March 2023

Abstract
Purpose
Neonatal jaundice is a common clinical condition which can progress to acute bilirubin encephalopathy with serious consequences if diagnosis and treatment are delayed. Timely and frequent screening by parents at home has the potential for early identification of high bilirubin levels. In this study, we aimed to analyse the current evidence on the accuracy of smart phone applications to detect neonatal jaundice.
Methods
PubMed, EMBASE, EMCARE, MEDLINE, The Cochrane Library and Google Scholar were searched from inception until July 2022. Grey literature was searched on ‘Opengrey’ and ‘Mednar’ databases. We included prospective and retrospective cohort studies that recruited infants with a gestation of ≥ 35 weeks and reported paired total serum bilirubin (TSB) and smartphone app-based bilirubin (ABB) levels. Two reviewers independently selected the studies for inclusion. In case of discrepancies, discussions were held with the third reviewer prior to reaching consensus. We conducted the review using the guidelines of the Cochrane Collaboration Diagnostic Test Accuracy Working Group and reported using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses-diagnostic test accuracy (PRISMA-DTA) statement. The data was pooled using the random effects model. The outcome of interest was agreement between ABB and TSB measurements, provided as correlation coefficient. Certainty of Evidence (COE) was assessed based on GRADE guidelines.
Results
14 studies (n = 2256) were included in the meta-analysis. The number of infants in individual studies ranged between 35 and 530. The pooled correlation coefficient (r) was 0.77 [95% CI 0.69 to 0.83; p < 0.01], indicating a statistically significant and strong positive correlation between ABB and TSB. Reported sensitivities for predicting a TSB of 250 µmol/L in individual studies ranged between 75 and 100% and specificities 61 to 100%. Similarly, a sensitivity of 83 to 100% and a specificity of 19.5 to 76% were reported for predicting a TSB of 205 µmol/L. Overall COE was considered moderate.
Conclusions
Smart phone App based bilirubin estimation showed a strong correlation to TSB levels. Well-designed studies are required to determine its utility as a screening tool for various TSB cut-off levels to commence phototherapy.
Antimicrobial activity of nature-inspired molecules against multidrug resistant bacteria
Authors: Hamad Mohamad , Al-Marzooq Farah , Srinivas Vunnam , Sulaiman Ashna , Al-Tel Taleb H. 
Published: March 2023

Abstract
Multidrug-resistant bacterial infections present a serious challenge to global health. In addition to the spread of antibiotic resistance, some bacteria can form persister cells which are tolerant to most antibiotics and can lead to treatment failure or relapse. In the present work, we report the discovery of a new class of small molecules with potent antimicrobial activity against Gram-positive bacteria and moderate activity against Gram negative drug resistant bacterial pathogens. The lead compound SIMR 2404 had a minimal inhibitory concentration (MIC) of 2 µg/ml against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-intermediate Staphylococcus aureus (VISA). The MIC values against Gram negative bacteria such as Escherichia coli and Actinobacteria baumannii were between 8–32 µg/ml. Time kill experiments show that compound SIMR 2404 can rapidly kill tested bacteria. Compound SIMR 2404 was also found to rapidly kill MRSA persisters which display high levels of tolerance to conventional antibiotics. In antibiotic evolution experiments, MRSA quickly developed resistance to ciprofloxacin but failed to develop resistance to compound SIMR 2404 even after 24 serial passages. The rapid antibacterial activity against both active and persister MRSA and to a lesser extent against Gram negative bacteria, suggest the potential of these molecules for further evaluation as antibacterial agents.
Changes in the dry eye parameters of patients with different preoperative ocular surface disease index scores after small incision lenticule extraction
Authors: Cui Ge , Wang Tianjiao , Di Yu , Yang Shan , Li Ying , Chen Di 
Published: March 2023

Abstract
To evaluate the changes in the ocular surface disease index (OSDI) scores and dry eye parameters of patients with different preoperative OSDI scores after small incision lenticule extraction (SMILE) surgery. Prospective research. Participants were divided into two groups: Group A, OSDI < 13; and Group B, OSDI ≥ 13. The OSDI scores, tear meniscus height (TMH), first non-invasive tear film break-up time (NIBUT-First), and meibomian gland loss (MGL, %) were recorded at postoperative 1 -week and 1-month.113 eyes (57 patients) were enrolled, 70 eyes in Group A, and 43 eyes in Group B. In Group A, the OSDI scores significantly increased at 1-week and 1-month postoperative (all P < 0.001); the TMH, NIBUT-First and lipid layer grade significantly decreased at postoperative 1-week (P = 0.003, 0.005, 0.007, 0.004, respectively), but returned to preoperative level at 1-month postoperative. In Group B, only the lipid layer grade significantly decreased at postoperative 1-week (P < 0.05). Patients with different preoperative OSDI scores may experience different changes early after SMILE surgery. Patients with OSDI scores < 13 may experience more dramatic changes in dry eye symptoms which would resolve, while subjective complains could still exists at 1 month post-surgery.
Association of an eight-gene signature prognosis model with tumor immunity in medulloblastoma
Authors: Jiang Tao , Han DongMing , Jia Zetian , Zou Wanjing , Liu Raynald , Hu Yuhua , Qiu Xiaoguang , Li Chunde , Liu Hailong , Li Jiankang 
Published: March 2023

Abstract
Background
The tumor microenvironment (TME) plays an important role in cancer progression. We investigated TME-specific gene signatures and established a risk score to predict the outcome of medulloblastoma (MB) patients.
Methods
We evaluated TME parameters of 240 MB patients at Beijing Tiantan Hospital Capital Medical University with the ESTIMATE algorithm. Co-expression network analysis of differentially expressed and weighted genes (WGCNA) was used to identify intersecting genes. Using least absolute shrinkage and selection operator regression and backward stepwise regression we obtained a TME-associated risk score (TMErisk) based on eight prognostic gene signatures (CEBPB, OLFML2B, GGTA1, GZMA, TCIM, OLFML3, NAT1, and CD1C), verified in a GEO dataset (GSE85217).
Results
The correlation between TMErisk and TME, immune checkpoint, mRNAsi, and tumor mutation burden (TMB) was analyzed. MB patients’ response to immunotherapy was evaluated using immune-phenoscore (IPS) and drug sensitivity. A high TMErisk score indicated a worse overall survival. TMErisk scores were negatively correlated with immune cells, immune checkpoints, and human leukocyte antigens. TMErisk scores correlated significantly negatively with TMB and IPS for specific molecular subtypes. Tumor mRNAsi was associated with TME-risk.
Conclusions
A prognostic model based on TME-specific gene signatures may be used as a biomarker for evaluating prognosis and predicting response to immunotherapy in MB patients.
Curdione regulates ferroptosis in colorectal cancer via N6-methyladenosine
Authors: Wang Fang , Sun Zheng , Yang Hao , Yang Gang , Zhang Qunyao , Yang Qi , Zhu Yimiao , Xu Wenwen , Wu Xiaoyu 
Published: March 2023

Abstract
Background: Curdione is a sesquiterpene isolated from Curcumae Rhizoma with high biological activity and a wide range of pharmacological effects. The traditional Chinese medicine Curcumae Rhizoma inhibits the development of many types of cancer, especially colorectal cancer, but the anti-colorectal mechanism of its monomer Curdione is vacant.
Methods: CT26 cells were treated with 12.5 μM, 25 μM, and 50 μM of Curdione, and cell activity was measured by MTT. Nude mice were implanted subcutaneously with different doses of Curdione and oxaliplatin by tail vein injection, and tumor histology was examined by HE staining. Flow cytometry was used to detect ROS in cells and tissues. Kits were used to detect levels of iron ions, MDA and GSH. PCR and western blot were used to detect ferroptosis and m6A modification-related factors. The methylation spot hybridization assay detected quantitative changes in overall methylation. MeRIP-qRNA measured SLC7A11 and HOXA13. shRNA-METTL14 plasmid was constructed to verify the inhibitory effect of Curdione on colorectal cancer.
Results: A dose-dependent decrease in activity was observed in Curdione-treated cells. Curdione increased the accumulation of ROS in colorectal cancer cells and tumor tissues, significantly increased the levels of MDA and Fe2+, and decreased the activity of GSH. qPCR and Western blot results showed that Curdione promoted the expression of METTL14 and YTHDF2 in colorectal cancer cells and tissues, and decreased the expression of SLC7A11, SLC3A2, HOXA13, and GPX4 expression. In addition, in animal experiments, HE staining showed that the Curdione -treated group showed significant necrosis of tumor cells. Moreover, the levels of m6A modifying factors, namely SLC7A11 and HOXA13, were increased in the tissues after the drug intervention compared to the control group. The knockdown of METTL14 was followed by an increase in CT26 cell activity and a decrease in reactive oxygen species. Cellular activity and GSH levels decreased after Curdione treatment. Levels of ROS, MDA, and iron ions increased significantly.
Conclusion: These results suggest that Curdione induces ferroptosis in colorectal cancer via m6A methylation.
The Carbon Emissions of Writing and Illustrating Are Lower for AI than for Humans
Authors: Tomlinson Bill , Black Rebecca W. , Patterson Donald J. , Torrance Andrew W. 
Published: March 2023

Abstract
As AI systems proliferate, their greenhouse gas emissions are an increasingly important concern for human societies. In this article, we present a comparative analysis of the carbon emissions associated with AI systems (ChatGPT, BLOOM, DALL-E2, Midjourney) and human individuals performing equivalent writing and illustrating tasks. Our findings reveal that AI systems emit between 130 and 1500 times less CO2e per page of text generated compared to human writers, while AI illustration systems emit between 310 to 2900 times less CO2e per image than their human counterparts. Emissions analyses do not account for social impacts such as professional displacement, legality, and rebound effects. In addition, AI is not a substitute for all human tasks. Nevertheless, at present, the use of AI holds the potential to carry out several major activities at much lower emission levels than can humans.
White and green striate leaves 1, predicted to encode a 16S rRNA processing protein, plays a critical role in the processing of chloroplast ribosomes in maize (Zea mays L.)
Authors: li qigui , Du Jiyuan , Qiao Zhenghao , Pan Chao , He Weiqiang , Zhang Li , Li Xiaohu , Nie Yongxin , Li Xinzheng , Pan Guangtang , Zhang Zhiming , Li Gaoke , Ding Haiping 
Published: March 2023

Abstract
Ribosomes play a crucial role in protein biosynthesis and are linked to plant growth and development. The RimM protein has been shown to involved in the maturation of 30S ribosomal subunits, but its exact function in plants is still unknown. In this study, we discovered a maize mutant with white and green striate leaves (wgsl1) and reduced chlorophyll content. Genetic analysis showed that the wgsl1 mutation was recessive and controlled by a single nuclear gene. Map-based cloning of ZmWGSL1 identified a base substitution (G to A) that generated a missense mutation within the Zm00001d039036 gene in the wgsl1 mutant. Zm00001d039036 encodes a 16S rRNA processing protein containing the RimM motif. Further analysis of transcriptomic data showed that the transcript levels of many ribosomal proteins involved in the small and big ribosomal subunits were dramatically up-regulated in the wgsl1 mutant. Moreover, the level of ribosomal multimers was decreased. This suggests that ZmWGSL1 plays a crucial role in the maturation of the ribosome, leading to abnormal plant growth and development. In addition, subcellular localization results indicate that WGSL1 is localized in chloroplasts. Therefore, we suggest that WGSL1 is synthesized in the nucleus, is transported to the chloroplast to drive functions, and affects the processing of ribosomes in the chloroplast.
Brazilin inhibits the inflammatory immune response induced by LPS in THP-1 cells
Authors: Han Deting , Ma Tao , Sun Shanmei , Zhang Yameng , Song Lucheng 
Published: March 2023

Abstract
Objective
To investigate the inhibitory effect of Brazilin (BN) on the inflammatory response of THP-1-derived macrophages induced by LPS.
Methods
THP-1 cells were induced with PMA to extend pseudopodia and form macrophages, and the inflammatory model was induced by LPS. The cell survival rate intervented by Brazilin was determined by the CCK-8 method, and the expression of PD-1 was detected by Flow cytometry, and contents of the cytokines IL-10 and TNF-α in the extracted supernatant of THP-1 cells were detected by ELISA, and the mRNA level was detected by RT‒PCR, while the protein level were detected by Western blot.
Results
The results showed that the best concentration of Brazilin was 12 µg/mL. The best concentration of simvastatin was 15 µg/mL, and the growth was concentration dependent. The expression of PD-1 on the cell surface in the two groups was significantly decreased compared with the control group, and the differences in the Brazilin group and the simvastatin group were significant (P < 0.01; P < 0.001; P < 0.001). The concentrations of TNF-α in the drug groups were significantly decreased while the IL-10 concentration was increased, and compared with the model group, the two drug groups were highly statistically significant (P < 0.001). The mRNA and the protein expression levels of PD-1, NF-κB, TLR4 and MMP-9 in the test groups had extremely significant difference compared with the model group (P < 0.001).
Conclusion
Brazilin can inhibit the abnormal activation of PD-1, TLR4, NF-κB and MMP-9 and is a good anti-AS drug that can not only reduce blood lipids but also have immunoregulatory and anti-inflammatory activity, laying a solid theoretical foundation for future screening and development of anti-AS drugs.
Age-specific high-sensitivity C-reactive protein is superior to age-specific procalcitonin for diagnosing early- onset bacterial infection in term neonates
Authors: Naramura Tetsuo , Iwai Masanori , Yoshimatsu Hidetaka , Nakamura Tomomi , Imamura Hiroko , Hattori Yusuke , Noda Yusuke , Tanaka Kenichi , Matsumoto Shirou , Mitsubuchi Hiroshi , Nakamura Kimitoshi 
Published: March 2023

Abstract
Purpose: To investigate the predictive usefulness of age-adjusted cutoff values of high-sensitivity C-reactive protein (hs-CRP) and procalcitonin (PCT) for early-onset bacterial infection (EOBI) in term neonates.
Methods: Serumhs-CRP and PCT levels in term neonates were compared among the no-symptom reference (REF), non-infectious respiratory failure (NIRF), and suspected bacterial infection (SBI) groups at birth and 1-18 h, 19-36 h, and 37-72 h postnatally. The predictive cutoff values of serum hs-CRP and PCT for EOBI were analyzed using a receiver operating characteristic (ROC) curve for each time frame.
Results: Serum levels of hs-CRP and PCT in the NIRF group were significantly higher than those of the REF group at 1-72 h postnatally. Serum hs-CRP levels were significantly higher in the SBI group than in the NIRF group at all time points, but serum PCT levels had significance only at 1-18 h postnatally. ROC analysis for predicting EOBI showed that hs-CRP had a better area-under-the-curve, specificity, positive predictive value, and negative predictive value than did PCT at all time points. The best predictive cutoff value of serum hs-CRP for EOBI was 18.4 mg/L at 19-36 h postnatally, which was higher and occurred earlier than the most used serum hs-CRP cutoff value of 10 mg/L in the first several days of life in neonates.
Conclusions: Age-adjusted hs-CRP cutoff values had better predictive power than age-adjusted PCT cutoff values for EOBI in term neonates during the first 72 h postnatally. Using age-specific hs-CRP may reduce prophylactic antibiotic administration for suspected EOBI in term neonates.
Correlations between Castelli’s Risk Index and Subclinical Coronary Atherosclerosis
Authors: gu xiaosong , Song Jinyou , Chao Tang , Su Tianhong , Du Shiyu , Qiao Shunsong , Zhu Jingjing , Zhao Fan 
Published: March 2023

Abstract
Objective
To investigate the relations between blood lipid level, plasma atherogenic index and coronary artery structural changes in patients with subclinical coronary atherosclerosis.
Method
209 patients who had accomplished Coronary CT Angiography (coronary CTA) are selected. the patients were classified into subclinical coronary atherosclerosis group (n = 124) and the normal group (n = 85). The clinical data of all patients were collected. Non-high-density lipoprotein, plasma atherogenic index, Castelli risk index and atherosclerosis coefficient were calculated according to the four items of blood lipids.
Results
There were significant differences between the subclinical coronary atherosclerosis group and the normal group in terms of gender, smoking history, and history of Hyperuricemia (P < 0.05), and the levels of Non-HDL-C, CRI-1, CRI-2, and AC were slightly higher than those in the normal group (P < 0.05).There was a correlation between subclinical coronary atherosclerosis and calcification score (P < 0.05). Logistic multivariate regression analysis showed that Smoking, Age and CRI-2 were independent risk factors for subclinical coronary atherosclerotic. The ROC of subclinical coronary atherosclerotic lesions diagnosed by CRI-2 was the largest, 0.611 (0.531–0.69).
Conclusion
Smoking, age and plasma CRI-2 level are associated with subclinical coronary atherosclerosis. CRI-2 in the plasma atherogenic index can be used for early screening of subclinical coronary atherosclerosis patients.