bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy and safety of Guipi Decoction in the treatment of chronic heart failure: A systematic review and meta-analysis of randomized controlled trials
Authors: Rong Yuanhang , Wu Di , Li Ming , Teng Jing 
Published: March 2023

Background:
Chronic heart failure (CHF) is the ultimate destination of most cardiovascular diseases and one of the leading causes of death for the elderly. Despite significant advances in the therapy of heart failure, the mortality and rehospitalization rates remain high. Guipi Decoction (GPD) has been reported to be significantly effective on patients with CHF, but it still lacks evidence-based medicine support.

Methods:
Two investigators systematically searched a total of 8 databases including PubMed, Embase, The Cochrane Library, Web of Science, Wanfang, China National Knowledge Infrastructure (CNKI), VIP, and CBM from construction to Nov 2022. Randomized controlled trials that compared GPD or in combination with conventional western medicine versus western medicine alone in the treatment of CHF were eligible for selection. The quality of included studies were evaluated and assigned data were extracted according to the method provided by Cochrane. All analyses used Review Manager 5.3 software.

Results:
The search identified 17 studies with a sample size of 1806 patients. Meta-analysis showed that GPD intervention was associated with an improvement in total clinical effective rate with a relative risk of 1.19 (95% confidence interval [CI] [1.15, 1.24]), P < .00001]. In terms of cardiac function and ventricular remodeling, GPT could improve left ventricular ejection fraction (mean difference [MD] = 6.41, 95% CI [4.32, 8.50], P < .00001), reduce left ventricular end diastolic diameter (MD = −6.22, 95% CI [−7.17, −5.28], P < .00001) and left ventricular end systolic diameter (MD = −4.92, 95% CI [−5.93, −3.90], P < .00001). In terms of hematological indices, GPD could decrease the levels of N-terminal pro-brain natriuretic peptide (standardized MD = −2.31, 95% CI [−3.05, −1.58], P < .00001) and C-reactive protein (MD = −3.51, 95% CI [−4.10, −2.92], P < .00001). And the analysis of safety revealed no significant differences in adverse effects between the 2 groups with a relative risk of 0.56 (95% CI [0.20, 0.89], P = .55).

Conclusion:
GPD can improve cardiac function and inhibit ventricular remodeling with few adverse effects. However, more rigorous and high-quality randomized controlled trials are needed to verify the conclusion.
Personalized 90Y-resin microspheres dose determination: a retrospective study on the impact of dosimetry software on the treatment of patients with selective internal radiotherapy
Authors: Pinaquy Jean-Baptiste , Lapuyade Bruno , Blanc Jean-Frederic , Hindié Elif , Papadopoulos Panteleimon , Debordeaux Frederic 
Published: March 2023

Introduction
The calculation of resin yttrium-90 (90Y-) microspheres activity for selective internal radiotherapy (SIRT) needs to be investigated.

Methods and materials
Analyses using Simplicit90Y (Boston Scientific, Natick, Massachusetts, USA) dosimetry software were performed to determine the concordance between the absorbed doses to the tumor (DT1 and DT2) and healthy liver (DN1 and DN2) during the pre-treatment and the post-treatment phases. An optimized calculation of the activity of 90Y-microspheres performed using dosimetry software was applied retrospectively to assess the impact of this calculation method on the treatment.

Results
DT1 ranged from 38.8 to 372 Gy, with a mean value of 128.9 ± 73.6 Gy and median of 121.2 Gy [interquartile range (IQR): 81.7–158.8 Gy]. The median DN1 and DN2 was 10.5 Gy (IQR: 5.8–17.6). A significant correlation was between DT1 and DT2 (r = 0.88, P < 0.001) and DN1 and DN2 (r = 0.96, P < 0.001). The optimized activities were calculated; the target dose to the tumor compartment was 120 Gy. No activity reduction was applied in accordance with the tolerance of the healthy liver. Optimization of the microspheres dosages would have resulted in a significant increase in activity for nine treatments (0.21–2.54 GBq) and a reduction for seven others (0.25–0.76 GBq).

Conclusions
The development of customized dosimetry software adapted to clinical practice makes it possible to use dosimetry to optimize the dosage for each patient.
Volume-based 18F-FDG PET analysis of cardiac sarcoidosis using the descending aorta as a reference tissue
Authors: Tsujimoto Masakazu , Fukushima Ayami , Kawai Hideki , Watanabe Masanori , Tanahashi Shingo , Sarai Masayoshi , Toyama Hiroshi 
Published: March 2023

Objective

18F-FDG PET can be used to calculate the threshold value of myocardial volume based on the mean standardised uptake value (SUVmean) of the aorta to detect highly integrated regions of cardiac sarcoidosis. The present study investigated the myocardial volume when the position and number of volumes of interest (VOIs) were changed in the aorta.

Methods
The present study examined PET/computed tomography images of 47 consecutive cardiac sarcoidosis cases. VOIs were set at three locations in the myocardium and aorta (descending thoracic aorta, superior hepatic margin and near the pre-branch of the common iliac artery). The volume was calculated for each threshold using 1.1–1.5 times the SUVmean (median of three cross-sections) of the aorta as the threshold to detect high myocardial 18F-FDG accumulation. The detected volume, correlation coefficient with the visually manually measured volume and the relative error were also calculated.

Results
The optimum threshold value for detecting high 18F-FDG accumulation was 1.4 times that of the single cross-section of the aorta and showed the smallest relative errors of 33.84% and 25.14% and correlation coefficients of 0.974 and 0.987 for single and three cross-sections, respectively.

Conclusion
The SUVmean of the descending aorta may be detected in good agreement with the visual high accumulation by multiplying the same threshold constant for both single and multiple cross-sections.
Gallstone ileus of the sigmoid colon: case report
Authors: Mouni Omar , Bouziane Mohamed , Gennuso Federico , Ramdani Abdelbassir , Sair Khalid 
Published: March 2023

Introduction:
Gallstone ileus is an uncommon cause of intestinal obstruction. It is caused when a gallstone migrates through an enterobiliary fistula (most often between the duodenum and the gallbladder) and is impacted in the digestive system, most often in the terminal ileum toward the ileocaecal valve.

Case Presentation:
Here the authors report the case of a 74-year-old woman who was admitted to Compiegne Hospital in France for a gallstone ileus with the sigmoid colon as the impaction site, which is an even more rare cause of intestinal obstruction. The enterobiliary fistula was between the colon and the gallbladder.
The gallstone was removed surgically with a colotomy, without treating the fistula, and after a failed endoscopic attempt to extract the stone. The follow-up was without complications, and a colposcopy showed spontaneous closure of the fistula after 6 weeks.

Discussion and Conclusion:
The surgical closure of an enterobiliary fistula is an option that should be considered, but it can lead to higher morbidity. That is why the authors opted out of it, especially considering that spontaneous closure of the fistulae can happen, as it did in our case.
The effectiveness of real-time computer-aided and quality control systems in colorectal adenoma and polyp detection during colonoscopies: a meta-analysis
Authors: Aslam Muhammad Fawad , Bano Shehar , Khalid Mariam , Sarfraz Zouina , Sarfraz Azza , Sarfraz Muzna , Robles-Velasco Karla , Felix Miguel , Deane Kitson , Cherrez-Ojeda Ivan 
Published: March 2023

Aims:
This meta-analysis aims to quantify the effectiveness of artificial intelligence (AI)-supported colonoscopy compared to standard colonoscopy in adenoma detection rate (ADR) differences with the use of computer-aided detection and quality control systems. Moreover, the polyp detection rate (PDR) intergroup differences and withdrawal times will be analyzed.

Methods:
This study was conducted adhering to PRISMA guidelines. Studies were searched across PubMed, CINAHL, EMBASE, Scopus, Cochrane, and Web of Science. Keywords including the following ‘Artificial Intelligence, Polyp, Adenoma, Detection, Rate, Colonoscopy, Colorectal, Colon, Rectal’ were used. Odds ratio (OR) applying 95% CI for PDR and ADR were computed. SMD with 95% CI for withdrawal times were computed using RevMan 5.4.1 (Cochrane). The risk of bias was assessed using the RoB 2 tool.

Results:
Of 2562 studies identified, 11 trials were included comprising 6856 participants. Of these, 57.4% participants were in the AI group and 42.6% individuals were in in the standard group. ADR was higher in the AI group compared to the standard of care group (OR=1.51, P=0.003). PDR favored the intervened group compared to the standard group (OR=1.89, P<0.0001). A medium measure of effect was found for withdrawal times (SMD=0.25, P<0.0001), therefore with limited practical applications.

Conclusion:
AI-supported colonoscopies improve PDR and ADR; however, no noticeable worsening of withdrawal times is noted. Colorectal cancers are highly preventable if diagnosed early-on. With AI-assisted tools in clinical practice, there is a strong potential to reduce the incidence rates of cancers in the near future.
Spontaneous coronary artery dissection (SCAD): a case report
Authors: Britel Driss , Nikièma Soumaila , Massimbo Désiré , Graham Emmanuel , Benyass Aatif , Lakhal Zouhair 
Published: March 2023

Introduction and Importance:
Spontaneous coronary artery dissection (SCAD) is often revealed by an acute coronary syndrome classified then as a MINOCA. The typical patient is a female patient with no or few cardiovascular risk factor. Our work aims to illustrate the effectiveness of medical treatment in patients with SCAD.

Case Report:
We report a case of a 56-year-old female patient who was admitted after 3 days of infarct-like thoracic pain related to an anterior extended ST-elevation myocardial infarction. The coronarography showed a SCAD of the left anterior descending coronary artery. The patient was discharged under medical treatment. Six weeks later, coronarography showed a perfused coronary artery.

Discussion:
Most cases of SCAD present as acute coronary syndrome. Coronary angiography remains the ‘first-line’ examination. The use of endocoronary imaging such as IVUS and optical coherence tomography is necessary in case of diagnostic doubt (especially in SCAD type 2 and 3). The optimal management of SCAD remains unclear. A conservative approach should be the preferred strategy.

Conclusion:
SCAD should be considered in any young woman presenting with suspicious chest pain with positive troponin. The diagnosis is initially angiographic and may require endocoronary imaging for greater accuracy. Conservative treatment remains the best option.
Collapsing focal segmental glomerulosclerosis secondary to COVID-19: A systematic review and meta-analysis
Authors: Qamar Mohammad A. , Kogut Lucas M. , Tebha Sameer S. , Arif Aabiya , Ninmol Jesse , Abdul Razzaque Muhammad R. , Qamar Khulud , Yosufi Abubakr 
Published: March 2023

Introduction:The renal system manifestations of coronavirus disease-2019 have been documented extensively; however, scientific literature remains scarce regarding collapsing glomerulopathy hence the need for this investigation.Methods:A comprehensive review was conducted covering a timeline from 1 January 2020 to 5 February 2022 without any restrictions. The data extraction was conducted independently, and articles were assessed for the risk of bias. Data analysis was conducted using Comprehensive Meta-Analysis version 3.3.070 and RevMan version 5.4 for pooled proportions and risk ratio (RR) between dialysis-dependent and independent treatment groups with aP-value less than 0.05 considered significant.Results:A total of 38 studies were included in this review, including 74 (65.9%) males. The mean age was 54.2 years old. The most common symptoms reported were related to the respiratory system (59.6%, 95% CI: 50.4–68.2%) and hematuria (34.2%, 95% CI: 26.1–43.4). Antibiotics (25.9%, 95% CI: 12.9–45.3%) was the commonest management used. Proteinuria was the most reported laboratory finding at 89.5% (95% CI: 82.4–93.9%), while the commonest microscopic finding was acute tubular injury (77.2%, 95% CI: 68.6–84.0%). An increased risk of the presence of symptoms (P=0.005) and microscopic findings (P=0.0003) related to collapsing glomerulopathy in dialysis-dependent group was noted with increased management (P=0.01) used in this group for coronavirus disease-2019 infection.Conclusion:The findings of this study portray the prognostic value of the variables (symptoms and microscopic findings, etc.) reported in the analysis. Hence this study serves as a foundation for future investigations that minimize the study’s limitations to provide a more robust conclusion.
Prostatic adenocarcinoma with transitional cell features among the Saudi Arabian population: a registry review
Authors: Ghazwani Yahya , Sabbah Belal N. , Algahfees Mohammad A. , Arabi Tarek Z. , Alageel Abdulrahman K. , Musalli Ziyad F. , Almutairi Ebtesam S. , Alasker Ahmed 
Published: March 2023

Introduction:
Prostate cancer is the third leading cause of death from cancer among American men. Acinar adenocarcinoma is the most common form of prostate cancer; however, there are several nonacinar adenocarcinoma variants, such as transitional cell carcinoma of the prostate and ductal adenocarcinoma.

Materials and Methods:
A retrospective cohort study was conducted on all Saudi patients diagnosed with adenocarcinoma of the prostate with transitional cell features. The data was collected from the Saudi Cancer Registry, which collects tumor data from all private, military, and Health Ministry hospitals in Saudi Arabia through five regional offices.

Results:
Out of 3608 patients, only 16 (0.44%) had adenocarcinoma with transitional cell features. All the tumors under investigation were malignant and constituted. Only 6.2% of the tumors were well-differentiated, 43.8% were moderately differentiated, and 50.0% were poorly differentiated. Among the included patients, 56.3% of the patients (n=9) died. There were no significant factors associated with death among patients, including the demographic and tumor-related variables.

Conclusion:
To the authors’ knowledge, this is the first study describing the prevalence of adenocarcinoma with transitional cell features and its characteristics in Saudi Arabia. The authors have demonstrated that this rare subtype may be more prevalent than what was originally believed. It is necessary for future studies to assess the effectiveness of various treatment modalities to combat it. Furthermore, identifying risk factors – if any – may be crucial in the prevention of its development among men worldwide.
Acute severe thrombocytopenia following iodinated radiographic contrast medium infusion: a case report
Authors: Sharawi Baraa M.M. , Bashir Bahaa M. , Al-Tell Abdallah , Hamdan Musab , Abulihya Mohand W. , Karama Akram J. 
Published: March 2023

Introduction:
Acute contrast-induced thrombocytopenia is an unusual complication, and it is a rare event with the use of modern low-osmolarity iodinated contrast medium. There are only a few reports that exist in English literature.

Case presentation:
The authors report the case of a 79-year-old male patient with severe, life-threatening thrombocytopenia after administration of intravenous nonionic low-osmolarity contrast medium. His platelet count dropped from 179×109/l to 2×109/l after 1 h of radiocontrast infusion. Which has returned gradually to normal level within days with corticosteroid administration and platelet transfusion.

Conclusion:
Iodinated contrast-induced thrombocytopenia is a rare complication with an unknown causative mechanism. There is no definitive treatment for this condition, with corticosteroids being used in most cases. The platelet count normalizes within a few days regardless of any interventions, but supportive treatment is important to avoid any unwanted complications. Further studies are still needed for a better understanding of the exact mechanism of this condition.
Mononeuropathy multiplex as a first manifestation of renal cell carcinoma: a case report
Authors: ALahmad Ali , Abbas Mona , Nakawah Aman M.O. , Yasmeeneh Abeer M. , Hamzeh Ghassan 
Published: March 2023

Introduction and Importance:
The neurologic symptoms that appear due to paraneoplastic syndrome may give manifestations of undiagnosed tumor, and give an opportunity for early detection and treatment of it.

Case Presentation:
Here the authors present a case of a 54-year-old woman who suffered from rapidly progressive muscle weakness, accompanied by right third cranial nerve palsy.

Clinical Discussion:
The nerve conduction study consistent with multiple mononeuropathy, and laboratories revealed undiagnosed diabetes mellitus but elevated erythrocyte sedimentation rate and the rapid progression prompted for additional investigations. Brain MRI, repetitive nerve stimulation, lumbar puncture, and paraneoplastic panel were all negative. Computed tomography scan with contrast for the abdomen showed a right renal mass consistent with renal cell carcinoma. The tumor was removed and steroids and intravenous immunoglobulin was started but without any clinical improvement because of the late presentation.

Conclusion:
Patients with renal cell carcinoma can present with paraneoplastic syndromes but multiple mononeuropathy are extremely rare. It is crucial to investigate for all possible causes of neuropathy and not attributing it to a new discovered diabetes in the presence of clinical and laboratory red flags such as rapid progression and elevated erythrocyte sedimentation rate.
Observational findings of transbronchial lung biopsy in patients with interstitial lung disease: a retrospective study in Aleppo University Hospital
Authors: Kashkash Fateh , Khorri Abdullah 
Published: March 2023

Background:Clinicians face a significant obstacle when attempting to diagnose interstitial lung disease (ILD) patients. However, a thorough clinical examination together with the proper imaging and diagnostic techniques may provide a reliable diagnosis of a particular kind of ILD, and invasive tests such as rigid bronchoscopy or surgical lung biopsy may not be necessary. The aim of this study is to determine the histologic outcomes of an ILD transbronchial lung biopsy (TBLB) carried out at the university hospital in Aleppo.Methods:This retrospective cohort research was done between 1 January 2020 and 18 April 2022 at the pulmonary department of Aleppo University Hospital, Syria, using patient records. In our study, 174 patients were examined. We included patients over the age of 18 who were referred or admitted to our department at Aleppo University Hospital after being diagnosed with diffuse parenchymal lung disease based on high-resolution computed tomography and clinical symptoms, while excluding other respiratory diseases such as tuberculosis and coronavirus disease 2019.Results:Patients in the research were 53±7.1 years old on average. Cough and dyspnea were the most common clinical complaints among the patients, which accounted for 79.12 and 78.16%, respectively. A significant fraction of ground-glass opacity was detected on the high-resolution computed tomography, amounting to 102 (58.62%) and 74 (42.53%) for the reticular lesions, respectively. As a complication there were 40 patients with bleeding, of whom 24 had moderate bleeding, and 11 had major bleeding. We also had three patients with pneumothorax. The diagnostic yield of the TBLB in our ILD patients was 66.66%.Conclusion:An adequate diagnostic accuracy (66.66%) was detected in the TBLB in confirming the diagnosis of ILD; in addition, the bleeding was the most prevalent complication of this procedure. More interventional studies are needed to compare the diagnostic accuracy of this procedure with other invasive and noninvasive diagnostic methodologies of ILD.
Activation of tuberculosis in recovered COVID-19 patients: a case report
Authors: Al-kayali Rawaa S. , Kashkash Mohamad F. , Alhussein Alhajji Azzam H. , Khouri Abdullah 
Published: March 2023

Introduction and Importance:
Currently, coronavirus disease 2019 (COVID-19) and tuberculosis (TB) are among the most important causes of respiratory infections around the world. Both of them are sources of concern for human health and life safety. COVID-19 caused the deaths of millions of people, and many of them suffered from what has become known as ‘post-COVID squeal’. Immunosuppression is one of the most important of these symptoms that leave patients susceptible to severe infections like TB.

Case Presentation:
In these two cases, the authors observed the development of active TB after a period of COVID recovery. Two patients who were admitted to the hospital complained mainly, among other symptoms, of fever and a continuous cough after a period of COVID-19 recovery.

Clinical Discussion:
Radiological examination revealed a caving density in the two cases, and the Gene-Xpert test proved the presence of Mycobacterium tuberculosis bacteria despite the negative result of the Ziehl–Neelsen stain. The two patients were improved after standard TB treatment.

Conclusion:
Patients with post‐COVID‐19 chronic respiratory symptoms should be screened for TB, especially in TB-endemic areas, even though the result of the Ziehl–Neelsen stain was negative.
Assessment of motivating and demotivating factors to undergo bariatric surgery in high-risk populations with correlation to generalized anxiety disorder and influence of others: a cross-sectional study
Authors: Mousa Ahmed H. , Alahmad Kutaiba O. , Alsharabi Ayman H. , Ibrahim Abdullatif S. , Aljaber Abdulrahman J. , Baabbad Hasan M. , Althoubity Abdullah D. , Aldeghari Ahlam A. , Ikram Nadeem 
Published: March 2023

Background:
Very few research have looked at the causes and influences that push individuals into bariatric surgery. Although bariatric surgery is effective in boosting self-esteem, little is known about the precise physical characteristics people want to alter.

Methods:
This study was a descriptive, correlational cross-sectional study to achieve the objectives of the study. All overweight and obese population in Jeddah, Saudi Arabia. Study instrument was designed based on the data present in the latest literature. Study tool consisted of: (1) sociodemographic data, (2) motives of bariatric surgery, (3) concerns about bariatric surgery, (4) people affecting the decision of seeking bariatric surgery, and (5) general anxiety disorder scale.

Results:
The study included 567 participants. More than half of the study participants were females (n=335, 59.1%). The mean age among study participants was 27.88 years. Most of the participants selected themselves as the main person (n=329). In the second place comes “person who had the surgery” (n=72). A family member was prevalent among 59 participants and a friend among 57 participants. The partner has the least frequency. The most common reason was self-esteem among 26% followed by body image among 20%. The most frequent factor was “I am satisfied with my current weight loss method) among 220 participants followed by “I am afraid of any surgery and will avoid it unless absolutely needed” among 51 participants.

Conclusion:
Bariatric surgery patients want to improve their health and live longer. Several people are dissatisfied with their bodies and seek cosmetic surgery. Patients desire bariatric surgery for their own and their loved ones’, physicians’, and peers’ reasons. This study supports emphasizing the reasons why Jeddah, Saudi Arabia residents choose bariatric surgery and the demotivating issues.