bluuebunny/crossref_metadata_2025_split huggingface dataset:
O Ninho Cheio: Percepções do Subsistema Parental
Authors: Boeckel Mariana Gonçalves , Lahm-Vieira Camila Roberta 
Published: July 2023

A contemporaneidade trouxe mudanças nas configurações familiares e na forma como as famílias estão vivenciando o ciclo familiar. Assim, o ciclo vital da família sofreu alterações, dentre as quais se destaca o prolongamento do tempo de permanência dos filhos no lar parental. Este artigo apresenta um relato de pesquisa qualitativa, a qual objetivou conhecer as percepções dos pais com relação aos processos envolvidos na permanecia do jovem adulto em casa.
Molecular Beam Epitaxy Deposition of In Situ O‐Doped CdS Films for Highly Efficient Sb2(S,Se)3 Solar Cells
Authors: Li Ke , Cai Zhiyuan , Yang Junjie , Wang Haolin , Zhang Lijian , Tang Rongfeng , Zhu Changfei , Chen Tao 
Published: July 2023

AbstractAntimony selenosulfide (Sb2(S,Se)3) is considered as a promising light‐harvesting material and has been widely used in solar cells. For high‐efficiency Sb2(S,Se)3 solar cells, the most commonly used electron‐transporting layer of cadmium sulfide (CdS) is generally prepared by chemical bath deposition (CBD) approach. However, the hazardous waste liquid from the chemical bath and the sensitivity of the deposition process to the environment are challenges to practical applications. Herein, a molecular beam epitaxy deposition is reported to prepare CdS films, overcoming the drawbacks of CBD process. Furthermore, through introducing oxygen during the deposition of CdS, the sulfur vacancy defects generated in the vacuum deposition process are suppressed. The performance of Sb2(S,Se)3 solar cells is accordingly improved significantly. This improvement is attributed to the following aspects: i) the improved optical transmittance of CdS films. ii) The enhanced [hk1] orientation of Sb2(S,Se)3 absorber layer. iii) The improved heterojunction quality and suppressed carrier recombination. As a result, a power conversion efficiency of 8.59% for Sb2(S,Se)3 solar cells is achieved. This study provides a novel strategy for preparing electron‐transporting layers for efficient chalcogenide thin‐film solar cells and sheds new light on large‐area solar cell applications.
Electrohydrodynamic Printing of High‐Resolution Self‐Reduced Soldered Silver Nanowire Pattern for Wearable Flexible Strain Sensors
Authors: Hu Xuanyi , Feng Jiayun , Zhang He , Ma Jingxuan , Wu Zhuohuan , Wen Jiayue , Wang Shang , Tian Yanhong 
Published: July 2023

AbstractAs an indispensable aspect of flexible and printed electronics, flexible strain sensors composed of silver nanowires (AgNWs) have attracted significant attention recently. However, low resolution and large wire‐wire contact resistance still impede the stability and sensitivity of AgNW‐based flexible strain sensors. Herein, self‐reduced soldered AgNW pattern is fabricated by combining the high‐resolution electrohydrodynamic (EHD) printing and joining of AgNWs. The resolution achieved by EHD printing is up to ≈20 µm. The contact resistance between AgNWs is greatly reduced by depositing Ag atoms at the AgNW junctions while EHD printing Ag ion ink on as‐prepared AgNW pattern. After self‐reduced soldering process, the sheet resistance decreases from 14.8 to 2.13 Ω sq−1. This process can be conducted under room temperature and ambient conditions and requires no external assistance from heat, light, or mechanical pressing. Furthermore, the deposited Ag atoms at the junctions remarkably improve the sensitivity (gauge factor 14.5–37.9) and stability (over 5000 stretching cycles with 25% strain). This superior sensitivity and stability occur because nano‐junctions induced by the self‐reduced soldering process significantly reduce the initial resistance and enable a robust network structure. This EHD‐based technique for nanojoining of AgNWs demonstrates its potential for flexible and wearable electronics.
The Oxysterol Receptor EBI2 Links Innate and Adaptive Immunity to Limit IFN Response and Systemic Lupus Erythematosus
Authors: Zhang Fang , Zhang Baokai , Ding Huihua , Li Xiangyue , Wang Xilin , Zhang Xiaomin , Liu Qiaojie , Feng Qiuyun , Han Mingshun , Chen Longlong , Qi Linlin , Yang Dan , Li Xiaojing , Zhu Xingguo , Zhao Qi , Qiu Jiaqian , Zhu Zhengjiang , Tang Huiru , Shen Nan , Wang Hongyan , Wei Bin 
Published: July 2023

AbstractSystemic lupus erythematosus (SLE) is a complex autoimmune disease with abnormal activation of the immune system. Recent attention is increasing about how aberrant lipid and cholesterol metabolism is linked together with type I interferon (IFN‐I) signaling in the regulation of the pathogenesis of SLE. Here, a metabonomic analysis is performed and increased plasma concentrations of oxysterols, especially 7α, 25‐dihydroxycholesterol (7α, 25‐OHC), are identified in SLE patients. The authors find that 7α, 25‐OHC binding to its receptor Epstein–Barr virus‐induced gene 2 (EBI2) in macrophages can suppress STAT activation and the production of IFN‐β, chemokines, and cytokines. Importantly, monocytes/macrophages from SLE patients and mice show significantly reduced EBI2 expression, which can be triggered by IFN‐γ produced in activated T cells. Previous findings suggest that EBI2 enhances immune cell migration. Opposite to this effect, the authors demonstrate that EBI2‐deficient macrophages produce higher levels of chemokines and cytokines, which recruits and activates myeloid cells,T and B lymphocytes to exacerbate tetramethylpentadecane‐induced SLE. Together, via sensing the oxysterol 7α, 25‐OHC, EBI2 in macrophages can modulate innate and adaptive immune responses, which may be used as a potential diagnostic marker and therapeutic target for SLE.
A Mechanistic Study about the Formation of Tetracyanobutadienes Revealed an Autocatalytic Behavior
Authors: Lemiègre Loïc , Trolez Yann 
Published: July 2023

AbstractIn a recent paper in Chemistry – A European Journal, Nielsen and coworkers reported a deep study on the mechanism of the [2+2] cycloaddition‐retroelectrocyclization (CA‐RE) between an electron‐rich alkyne and tetracyanoethylene (TCNE), inducing the formation of a 1,1,4,4‐tetracyanobutadiene (TCBD). Following a robust kinetic study, the authors confirmed important intermediates and determined this reaction to be autocatalytic for the first time. Given the increasing use of TCBDs in the community and the strength of the CA‐RE reaction this paper offers important insights for future developments of this promising reaction.
Facile approach for imparting shape memory behavior to traditional thermoplastic polyurethane via interaction between different hard segments
Authors: Wang Yujie , Nie Huifang , Wang Shimin , Zhang Hao , Zhang Xiaofeng , Huang Miaoming , Liu Wentao 
Published: July 2023

AbstractThe stability of hard domain is a key factor affecting the shape memory properties of thermoplastic polyurethane (TPU). However, the physical interaction in hard domains is weak for most kinds of TPU, leading to a plastic deformation and thus significantly decreasing the shape recovery ratio of TPU. In this work, a new strategy for constructing shape memory TPU was proposed, and the blends was prepared by simple solution mixing based on IPDI‐PU and HDI‐PU, in which isophorone diisocyanate (IPDI) with alicyclic structure was introduced in hard segments of IPDI‐PU, and hexamethylene diisocyanate (HDI) with linear structure was introduced in hard segments of HDI‐PU. With the introduction of HDI‐PU into IPDI‐PU, hydrogen bonds between mixed hard domains were formed more easily, which made it possible to tailor the stability of hard domains in PU blends by changing the composition of IPDI‐PU and HDI‐PU. Shape memory behavior of IPDI‐PU was difficult to be observed, while the shape fixity ratio and recovery ratio of the blends containing 30% HDI‐PU were respectively 94% and 72%. This simple and facile strategy can be used to develop the recyclable shape memory TPU, which will have a wider range of potential applications in smart devices.
Associated risks with periodontal x‐rays or CBCT scans: Are there any?
Authors: Pereira Rafael , Sabri Hamoun , Pereira Patricia , Wang Hom‐Lay 
Published: July 2023

AbstractPeriodontal and implant radiography, mainly including intra‐oral peri‐apical and cone beam computed tomography images, are crucial in the diagnosis and treatment planning process. However, radiation safety concerns have been a chronic concern over the years, leading to uncomfortable situations. It is therefore crucial to understand the actual radiation exposure to determine if the patients’ fear of necessary diagnostic exams is justified. In this perspective article, we aimed to provide concise information on dental imaging exposure, risks, and benefits, comparing them to that of absorbed radiation from daily life activities; and secondarily, to help periodontists choose the best option for each case and become more confident in addressing patients’ concerns and providing a summary of safety guidelines as a reference for them.
Pharmacokinetic and Bioequivalence Evaluation of Single‐Tablet and Separate‐Tablet Regimens for Ainuovirine, Lamivudine, and Tenofovir Disoproxil Fumarate in Chinese Healthy Subjects
Authors: Huang Lei , Lei Jing , Yang Yuanxun , Ma Tingting , Lin Hui , Cao Bei , Li Juan 
Published: July 2023

AbstractThis was a single‐dose, randomized, open‐label, 2‐period crossover study to evaluate the bioequivalence of the ACC008 (test formulation [T]) versus coadministered ainuovirine (ANV) 150 mg, lamivudine (3TC) 300 mg, and tenofovir disoproxil fumarate 300 mg (reference formulation [R]) in the fasted state among the Chinese healthy adults. Eligible subjects were randomized into 2 cohorts to received treatment in 1 of 2 sequences (T → R, R → T). PK samples were collected from 1 hour before dosing to 144 hours after dosing in each period. The concentrations of ANV, 3TC, and tenofovir in plasma were determined by liquid chromatography–tandem mass spectrometry. Phoenix WinNonlin software was used for pharmacokinetic parameter calculation and bioequivalence evaluation. All the 90% confidence intervals of maximum concentration, area under the concentration–time curve from time zero to the last detectable time, and area under the concentration–time curve from time zero to infinity fell within the bioequivalence range. The safety was comparable between the 2 treatments, with no Grade III/VI or serious adverse events. ACC008 was bioequivalent to administration of its individual components, including ANV 150 mg, 3TC 300 mg, and tenofovir disoproxil fumarate 300 mg with favorable safety profile.
The therapeutic potential of an allosteric non‐competitive CXCR1/2 antagonist for diabetic nephropathy
Authors: Grasselli Chiara , Bombelli Silvia , D’Esposito Vittoria , Di Tolla Michele Francesco , L’Imperio Vincenzo , Rocchio Francesca , Miscione Martina Sara , Formisano Pietro , Pagni Fabio , Novelli Rubina , Ruffini Pier Adelchi , Aramini Andrea , Allegretti Marcello , Perego Roberto , De Filippis Lidia 
Published: July 2023

AbstractAimsDiabetic nephropathy is a major consequence of inflammation developing in type 1 diabetes, with interleukin‐8 (IL‐8)‐CXCR1/2 axis playing a key role in kidney disease progression. In this study, we investigated the therapeutic potential of a CXCR1/2 non‐competitive allosteric antagonist (Ladarixin) in preventing high glucose‐mediated injury in human podocytes and epithelial cells differentiated from renal stem/progenitor cells (RSC) cultured as nephrospheres.Materials and MethodsWe used human RSCs cultured as nephrospheres through a sphere‐forming functional assay to investigate hyperglycemia‐mediated effects on IL‐8 signalling in human podocytes and tubular epithelial cells.ResultsHigh glucose impairs RSC self‐renewal, induces an increase in IL‐8 transcript expression and protein secretion and induces DNA damage in RSC‐differentiated podocytes, while exerting no effect on RSC‐differentiated epithelial cells. Accordingly, the supernatant from epithelial cells or podocytes cultured in high glucose was able to differentially activate leucocyte‐mediated secretion of pro‐inflammatory cytokines, suggesting that the crosstalk between immune and non‐immune cells may be involved in disease progression in vivo.ConclusionsTreatment with Ladarixin during RSC differentiation prevented high glucose‐mediated effects on podocytes and modulated either podocyte or epithelial cell‐dependent leucocyte secretion of pro‐inflammatory cytokines, suggesting CXCR1/2 antagonists as possible pharmacological approaches for the treatment of diabetic nephropathy.
Sustainability of cognitive behavioural interventions for chronic back pain: A long‐term follow‐up
Authors: Riecke Jenny , Rief Winfried , Lemmer Gunnar , Glombiewski Julia A. 
Published: July 2023

AbstractBackgroundThere is a significant research gap with respect to the long‐term sustainability of psychological treatment effects in chronic pain patients. This study aimed to investigate long‐term treatment effects of two psychological treatments: cognitive behavioural therapy (CBT) as a broad‐spectrum approach and exposure as a specific intervention for fear‐avoidant pain patients.MethodsPatients with chronic low back pain were randomized to CBT or exposure in vivo. Long‐term follow‐up (LTFU) data were available for 64 patients up to 8 years after treatment, with a response rate of 73%. The primary outcomes were pain‐related disability and pain intensity and secondary outcomes were emotional distress, psychological flexibility, catastrophizing and pain‐related fear. The data analysis was performed with longitudinal multilevel modelling.ResultsMultilevel analyses showed improvements in all primary outcomes as well as all secondary outcomes from pre‐treatment to LTFU for both treatments. The mean proportion of cases meeting reliable and clinical improved criteria in all primary outcome was 36% (range: 22%–46%) in the exposure group and 50% (range: 33%–60%) in the CBT group. Dropout analyses revealed significantly higher deterioration rates over time. Pre‐treatment to LTFU effect sizes of the primary outcomes ranged from 0.54 to 1.59.ConclusionsOur results indicate that the effects of psychological treatments might be stable over several years. Treatment gains for exposure as a stand‐alone treatment seem to be of shorter duration than a general CBT intervention. Thus, psychological treatments might offer a promising and sustainable long‐term perspective for patients with chronic back pain.SignificanceThe long‐term stability of treatment effects is a highly neglected issue despite its inherent importance in the context of chronic pain. This study is the first to investigate treatment effects of cognitive behavioural therapy and in vivo exposure in chronic back pain sufferers up to 8 years after treatment. The findings contribute to an understanding of the sustainability of psychological cognitive behavioural therapy‐based intervention effects.
Quantifying rainfall and cloud water interception in upland forests of Norfolk Island
Authors: McJannet David , Marano Jordan , Petheram Cuan , Tavener Neil , Greenwood Derek 
Published: July 2023

AbstractThe higher elevation (>200 m ASL) forests of Norfolk Island are regularly immersed in the clouds and scientific and anecdotal evidence suggests that in addition to rainfall, water is likely to be collected as cloud droplets are intercepted by the forest canopy. This water is likely to be important for the local hydrology and ecology, yet it has never been quantified. To address this, a field measurement campaign was established to measure hydrological inputs to the forest floor at two elevated (290 and 310 m ASL) forest sites in the Norfolk Island National Park over a 524‐day period. Instrumentation included throughfall and stemflow measurement systems and recording rain gauges in the open in nearby clearings. Sites exhibited very high stem density and basal area and delivery of water to the forest floor was dominated by stemflow because of the funnelling characteristics of the dominant palm and pine trees. Both sites showed similar hydrological behaviour with stemflow and throughfall of around 48% and 32% of total atmospheric inputs, respectively. Stemflow contributions of 48% far exceed observations from the literature on cloud‐affected ecosystems which are typically less than 10%. Rainfall rarely occurred in the absence of low‐level cloud and some cloud immersion events lasted for many days with hydrologic inputs continuing for extended periods despite rainfall not being observed in the open. Cloud water interception accounted for approximately 20% of total water input at both sites which is equivalent to 25% extra water on top of rainfall measured in the open. From an island‐wide perspective, the calculated additional hydrological input is only small due to the limited spatial extent of upland forest; however, the additional water is likely to be very important to local hydrological processes and the unique plants, insects and animals which inhabit the upland forests of Norfolk Island.
Driving destination brand engagement: The role of traveler participation
Authors: Cheung Man‐Lai , Leung Wilson K. S. , Taheri Babak , Tse Sin Yan 
Published: July 2023

AbstractThis paper explores the importance of two forms of interactions, namely marketer–traveler interaction and traveler–traveler interaction in driving destination brand engagement (DBE) dimensions, and their effect on travelers' short‐term and long‐term behavioral intentions based on impulse buying and external search behavior. Using multi‐group analysis, the impact of DBE dimensions on external search behavior and impulse buying across Generation‐Z travelers (aged between 18 and 25) and Generation‐Y travelers (aged between 26 and 40) was also explored. The results provide meaningful implications for tourism marketers to drive relationships between travelers and destinations on digital tourism platforms.
Improvement of phoswich detector‐based β+/γ‐ray discrimination algorithm with deep learning
Authors: Kim Chanho , Kim Semin , Lee Yeeun , Park Chansun , Kim Sangsu , Kim Hyun Koo , Yeom Jung‐Yeol 
Published: July 2023

AbstractBackgroundPositron probes can accurately localize malignant tumors by directly detecting positrons emitted from positron‐emitting radiopharmaceuticals that accumulate in malignant tumors. In the conventional method for direct positron detection, multilayer scintillator detection and pulse shape discrimination techniques are used. However, some γ‐rays cannot be distinguished by conventional methods. Accordingly, these γ‐rays are misidentified as positrons, which may increase the error rate of positron detection.PurposeTo analyze the energy distribution in each scintillator of the multilayer scintillator detector to distinguish true positrons and γ‐rays and to improve the positron detection algorithm by discriminating true and false positrons.MethodsWe used Autoencoder, an unsupervised deep learning architecture, to obtain the energy distribution data in each scintillator of the multilayer scintillator detector. The Autoencoder was trained to separate the combined signals generated from the multilayer scintillator detector into two signals of each scintillator. An energy window was then applied to the energy distribution obtained using the trained Autoencoder to distinguish true positrons from false positrons. Finally, the performance of the proposed method and conventional positron detection algorithm was evaluated in terms of the sensitivity and error rate for positron detection.ResultsThe energy distribution map obtained using the trained Autoencoder was proven to be similar to that of the simulated results. Furthermore, the proposed method demonstrated a 29.79% (+0.42%p) increase in positron detection sensitivity compared to the conventional method, both having an equal error rate of 0.48%. However, when both methods were set to have the same sensitivity of 1.83%, the proposed method had an error rate that was 25.0% (−0.16%p) lower than that of the conventional method.ConclusionsWe proposed and developed an Autoencoder‐based positron detection algorithm that can discriminate between true and false positrons with a smaller error rate than conventional methods. We verified that the proposed method could increase the positron detection sensitivity while maintaining a low error rate compared to the conventional method. If the proposed algorithm is implemented in handheld positron detection probes or cameras, diseases such as cancers can be more accurately localized in a shorter time compared with using traditional methods.
Children's Oncology Group 2023 blueprint for research: Cancer care delivery research
Authors: Parsons Susan K. , Beauchemin Melissa P. , Dupuis Lee , Sugalski Aaron , Wolfson Julie Anna , Santacroce Sheila J. , Marchak Jordan G. , Sung Lillian , Roth Michael E. ,   the COG Cancer Care Delivery Research Committee
Published: July 2023

AbstractThe National Cancer Institute (NCI) has a 40‐year history of initiatives to encourage the participation of community oncology sites into clinical trials research and clinical care. In 2014, the NCI re‐organized to form the NCI Community Oncology Research Program (NCORP) network across seven research bases, including the Children's Oncology Group (COG), and numerous community sites. The COG portfolio for Cancer Care Delivery Research (CCDR), mirroring the larger NCORP network, has included two studies addressing guideline congruence, as an important marker of quality cancer care, and another focusing on financial toxicity, addressing the pervasive problems of healthcare cost. CCDR is a cross‐cutting field that frequently examines intersectional aspects of healthcare delivery. With that in mind, we explicitly define domains of CCDR to propel our research agenda into the next phase of the NCORP CCDR program while acknowledging the complex and dynamic fields of clinical care, policy level decisions, research findings, and needs of communities served by the NCORP network that will inform the subsequent research questions. To ensure programmatic success, we will engage a broad interdisciplinary group of investigators and clinicians with expertise and dedication to community oncology and the populations they serve.
Under‐Coordinated CoFe Layered Double Hydroxide Nanocages Derived from Nanoconfined Hydrolysis of Bimetal Organic Compounds for Efficient Electrocatalytic Water Oxidation
Authors: Ni Yuanman , Shi Dier , Mao Baoguang , Wang Sihong , Wang Yin , Ahmad Ashfaq , Sun Junliang , Song Fang , Cao Minhua , Hu Changwen 
Published: July 2023

AbstractHierarchically structured bimetal hydroxides are promising for electrocatalytic oxygen evolution reaction (OER), yet synthetically challenging. Here, the nanoconfined hydrolysis of a hitherto unknown CoFe‐bimetal‐organic compound (b‐MOC) is reported for the controllable synthesis of highly OER active nanostructures of CoFe layered double hydroxide (LDH). The nanoporous structures trigger the nanoconfined hydrolysis in the sacrificial b‐MOC template, producing CoFe LDH core‐shell octahedrons, nanoporous octahedrons, and hollow nanocages with abundant under‐coordinated metal sites. The hollow nanocages of CoFe LDH demonstrate a remarkable turnover frequency (TOF) of 0.0505 s−1 for OER catalysis at an overpotential of 300 mV. It is durable in up to 50 h of electrolysis at step current densities of 10–100 mA cm−2. Ex situ and in situ X‐ray absorption spectroscopic analysis combined with theoretical calculations suggests that under‐coordinated Co cations can bind with deprotonated Fe‐OH motifs to form OER active Fe‐O‐Co dimmers in the electrochemical oxidation process, thereby contributing to the good catalytic activity. This work presents an efficient strategy for the synthesis of highly under‐coordinated bimetal hydroxide nanostructures. The mechanistic understanding underscores the power of maximizing the amount of bimetal‐dimer sites for efficient OER catalysis.