bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sequencing of Endocrine and Targeted Therapies in Hormone-Sensitive, Human Epidermal Growth Factor Receptor 2–Negative Advanced Breast Cancer
Authors: Jackson Emily B. , Chia Stephen K.L. 
Published: July 2023

The Oncology Grand Rounds series is designed to place original reports published in the Journal into clinical context. A case presentation is followed by a description of diagnostic and management challenges, a review of the relevant literature, and a summary of the authors' suggested management approaches. The goal of this series is to help readers better understand how to apply the results of key studies, including those published in Journal of Clinical Oncology , to patients seen in their own clinical practice. Optimizing the selection and sequencing of endocrine and targeted therapies for hormone-sensitive, human epidermal growth factor receptor 2 (HER2)–negative advanced breast cancer is a rapidly evolving field owing in large part to an increasing pace of drug development coupled with a greater understanding of the genomic drivers of breast cancer. The recently published results from the MAINTAIN clinical trial begin to answer an important question in this patient population—can the well-established benefit with first-line cyclin-dependent kinase 4/6 (CDK 4/6) inhibitors be stretched further by continuing this drug class beyond progression and selecting an alternate endocrine therapy partner? We present a case of a patient with hormone-sensitive HER2 low metastatic breast cancer who underwent circulating tumor DNA next-generation sequencing to better inform her treatment options after progression on first-line therapy with a CDK 4/6 inhibitor and aromatase inhibitor. Our clinical approach in this patient population prioritizes the identification of actionable mutations with high-quality evidence for efficacy on the basis of clinical trials post-CDK 4/6 inhibitors, while balancing comorbidities and patient priorities for care. Several recent clinical trials discussed herein present clinically meaningful results linking emerging targeted therapies to actionable alterations in PIK3CA, ESR1, AKT1, and PTEN. Continued drug development in this space delays time to treatment with chemotherapy, and hopefully contributes to maintaining a high quality of life for these patients on primarily oral-based therapy.
Utility of multiparametric renal CT for differentiation of low-grade from high-grade cT1a clear cell renal cell carcinoma
Authors: Pickovsky Jana S , Alo Nasiyabi Khalid , Eldihimi Fatma , Schieda Nicola 
Published: July 2023

Objective:
To determine if CT can differentiate low-grade from high-grade clear cell renal cell carcinoma (ccRCC) in cT1a solid ccRCC.

Methods and materials:
This retrospective cross-sectional study evaluated 78 &lt; 4 cm solid (&gt;25% enhancing) ccRCC in 78 patients with renal CT within 12 months of surgery between January 2016 and December 2019. Two radiologists (R1/R2), blinded to pathology, independently recorded mass:size, calcification, attenuation and heterogeneity (5-point Likert scale) and recorded a 5-point ccRCC CT Score. Multivariate logistic regression (LR) was performed.

Results:
There were 64.1% (50/78) low-grade (5/50 Grade 1 and 45/50 Grade 2) and 35.9% (28/78) high-grade (27/28 Grade 3 and 1/28 Grade 4) tumors.
Unenhanced CT attenuation was higher (35.9±10.3 R1 and 34.9±10.7 R2 high-grade vs 29.7±10.2 R1 and 29.5±9.8 R2 low-grade, p=0.01-0.02), absolute corticomedullary phase attenuation ratio (CMphase-ratio; 0.67±0.16 R1 and 0.66±0.16 R2 vs 0.93±0.83 R1 and 0.80±0.33 R2, p=0.04-0.05) and 3-tiered stratification of CMphase-ratio (p=0.02) lower in high-grade tumors.
A two-variable LR-model including unenhanced CT attenuation and CM.phase-ratio achieved area under the receiver operator characteristic curve of: 73% (95% confidence intervals 59–86%) and 72% (59–84%) for R1 and R2.
ccRCC CT score differed by ccRCC grade (p&lt;0.01 R1, R2) with high-grade tumors occurring most commonly in moderately enhancing ccRCC score 4 (46.4% [13/28] R1 and 54% [15/28]).

Conclusion:
Among cT1a ccRCC, high-grade tumors have higher unenhanced CT attenuation and are less avidly enhancing.

Advances in knowledge:
High-grade ccRCC have higher attenuation (possibly due to less microscopic fat) and lower corticomedullary phase enhancement compared to low-grade tumors. This may result in categorization of high-grade tumors in lower ccRCC diagnostic algorithm categories.
Πρόθεση εγκατάλειψης μεταπτυχιακών σπουδών: εφαρμογή της Θεωρίας του Αυτο-Προσδιορισμού
Authors: Σχοινά Χριστίνα-Ιωάννα , Γωνίδα Σοφία-Ελευθερία , Κιοσέογλου Γρηγόριος 
Published: July 2023

Στόχος της έρευνας ήταν η μελέτη προστατευτικών προβλεπτικών παραγόντων και παραγόντων κινδύνου της πρόθεσης εγκατάλειψης μεταπτυχιακών σπουδών. Η έρευνα βασίστηκε στη Θεωρία του Αυτο-Προσδιορισμού. Συνολικά συμμετείχαν 288 μεταπτυχιακοί/ές φοιτητές/ριες. Οι συμμετέχοντες/ουσες κλήθηκαν να απαντήσουν ηλεκτρονικά σε ένα ερωτηματολόγιο που αποτελούνταν από κλίμακες αυτο-αναφοράς, οι οποίες αξιολογούσαν την αντιληπτή υποστήριξη και ματαίωση των αναγκών από τους/τις καθηγητές/ριες, την οικογένεια και τους/τις συμφοιτητές/ριες τους, την αντιληπτή επάρκεια και αυτονομία, το αυτόνομο και ελεγχόμενο κίνητρο και την πρόθεση εγκατάλειψης των σπουδών. Για τη στατιστική ανάλυση εφαρμόστηκε ανάλυση διαδρομών. Ελέγχθηκαν δύο μοντέλα. Στο πρώτο, τις εξωγενείς μεταβλητές αποτελούσαν οι μεταβλητές της ικανοποίησης των αναγκών από φορείς του πλαισίου, ενώ στο δεύτερο η ματαίωση των αναγκών από τους ίδιους φορείς. Διαμεσολαβούσες μεταβλητές και στα δύο μοντέλα ήταν η επάρκεια, η αυτονομία και το αυτόνομο/ελεγχόμενο κίνητρο, ενώ εξαρτημένη μεταβλητή η πρόθεση εγκατάλειψης σπουδών. Στο πρώτο μοντέλο σημαντικοί προγνωστικοί παράγοντες αναδείχτηκαν η υποστήριξη των αναγκών από τους/τις καθηγητές/ριες, η επάρκεια και η αυτονομία, ενώ στο δεύτερο η ματαίωση των αναγκών από τους/τις καθηγητές/ριες και τους/τις συμφοιτητές/ριες, η επάρκεια, η αυτονομία και το αυτόνομο κίνητρο για τις σπουδές. Τα ευρήματα συζητιούνται υπό το πρίσμα της σύγχρονης θεωρίας και έρευνας στη διεθνή βιβλιογραφία, ενώ παράλληλα αναφέρονται οι περιορισμοί και διατυπώνονται προτάσεις εφαρμογής και μελλοντικής έρευνας.συμμετείχαν 288 μεταπτυχιακοί/ές φοιτητές/ριες. Οι συμμετέχοντες/ουσες κλήθηκαν να απαντήσουν ηλεκτρονικά σε ένα ερωτηματολόγιο που αποτελούνταν από κλίμακες αυτο-αναφοράς, οι οποίες αξιολογούσαν την αντιλαμβανόμενη υποστήριξη και ματαίωση των αναγκών από τους/τις καθηγητές/ριες, την οικογένεια και τους/τις συμφοιτητές/ριες τους, την αντιλαμβανόμενη επάρκεια και αυτονομία, το αυτόνομο και ελεγχόμενο κίνητρο και την πρόθεση εγκατάλειψης των σπουδών. Για τη στατιστική ανάλυση εφαρμόστηκε ανάλυση διαδρομών. Τα μοντέλα ήταν δύο. Στο πρώτο, τις εξωγενείς μεταβλητές αποτελούσαν οι μεταβλητές της υποστήριξης των αναγκών από φορείς του πλαισίου, ενώ στο δεύτερο η ματαίωση των αναγκών από τους ίδιους φορείς. Στο πρώτο μοντέλο σημαντικοί προγνωστικοί παράγοντες αναδείχτηκαν η υποστήριξη των αναγκών τους/τις καθηγητές/ριες, η αντιλαμβανόμενη επάρκεια και η αντιλαμβανόμενη αυτονομία, ενώ στο δεύτερο η ματαίωση των αναγκών από τους/τις καθηγητές/ριες και τους/τις συμφοιτητές/ριες, η αντιλαμβανόμενη επάρκεια , η αντιλαμβανόμενη αυτονομία και το αυτόνομο κίνητρο για τις σπουδές. Τα ευρήματα συζητώνται υπό το πρίσμα της σύγχρονης θεωρίας και έρευνας στη διεθνή βιβλιογραφία, ενώ παράλληλα αναφέρονται οι περιορισμοί και διατυπώνονται προτάσεις εφαρμογής και μελλοντικής έρευνας.
Exploring marginalized and privileged gender identities: the expectations of Muslim Roma adolescents on their future employment and family life
Authors: Sakka Despina , Papazoglou Irene 
Published: July 2023

The aim of the present study is to explore the expectations of adolescents of a minority (i.e., of Roma and Muslim cultural backgrounds from the area of Thrace)[1] and majority status (i.e., dominant group) on their future employment and family life as well as on gender relations. Ninety-one adolescents participated in the study (51 from the dominant group and 40 from the minority, 45 boys and 46 girls). While all participants from the dominant group attended the 3rd grade of Gymnasium or the 1st grade of Lyceum only 8 Muslim Roma participants did so. Adolescents were asked to fill in a questionnaire and to write a short essay titled "A day in my future family". Data were collected in written from the participants of the dominant group and orally from those of Muslim Roma origin. In addition to the statistical analysis, and with respect to the data from the essay, a thematic analysis was carried out in order to identify the adolescents’ images of their future life in both the private and the public sphere. The results of the study reveal the multiple gender identities that are constructed by culturally diverse, with respect to gender and social status, groups of adolescents. They, also, suggest that the participants’ views are shaped by the marginalized or privileged categories in which they belong to. Finally, results show that as boys and girls of both the minority and the dominant groups project themselves in the future, they try to actively construct the social context they will live in, to position themselves within it and to provide meaning to gender relations.

[1]The Thracian minority is the only officially recognized minority in Greece and its position is guaranteed by the Treaty of Lausanne (Dragonas & Fragoudaki, 2006). The Thracian minority is not an ethno-culturally homogenous group. Τhese are Greek citizens who are either Roma or of Turkish or Pomak origin. Moreover, it is accorded religious but not ethnic status.
Communicative, psychological and information-psychological impact in mass communication
Authors: Zaripov Ruslan 
Published: July 2023

The article is devoted to revealing the correlation between different types of communicative influence in interpersonal and mass communication. The relevance lies in the definition of the term "information-psychological impact", which eliminates the gap in the science of language, resulting from the expansion of the impact essence on the addressee beyond the purely verbal, and combines both linguistic and audiovisual means, the former implementing the verbal, and the latter – non-verbal impact.
Aim. To examine the relationship between communicative, psychological and information-psychological influences and define their conditional mutual boundaries in the context of interpersonal and mass communication.
Methodology and research methods. The study is based on an analysis of sources on communication theory, psychology, psycholinguistics, verbal impact linguistics, as well as information warfare and information-psychological influence. The methods of functional, communicative-pragmatic and synchronic-diachronic analysis are used. The work uses predominantly inductive-descriptive and comparative methods of presentation.
Results. The generic concept among the analyzed types of influence is communicative, which is associated with any type of information exchange, including those beyond the limits of verbal and audiovisual tools. Within the framework of verbal and non-verbal communication, the impact of the information subject can acquire a psychological character, if the mental state, social attitudes or psychological characteristics of the recipient relating to his activity, consciousness or personality are affected. Within the framework of mass communication, we should talk about the impact on the recipient's psyche by means of mass information – information-psychological impact.
Scientific novelty. Within the framework of communication theory, information-psychological warfare linguistics and applied linguistics in general, a definition of information-psychological influence is introduced, its essence is established and its main characteristics are noted.
Practical significance. The introduction of this term eliminates the terminological polyvalence that exists in communicative science regarding various types of impact, and from an applied point of view will make it possible to identify patterns of use of linguistic and extralinguistic means in media texts, as well as to analyse media materials related to the category of information and psychological weapons.
Analysis of the relationship between serum sodium concentration and laboratory parameters in diabetic patients
Authors: Aab Arkadiusz , Zarańska Julia , Kędra Kamila , Michalik Izabela , Bielak Maciej , Zarański Bartosz 
Published: July 2023

Introduction: Diabetes is a chronic civilization disease that is associated with numerous complications and disturbances in laboratory parameters. One of the observed changes in laboratory studies of individuals suffering from diabetes is a significantly low level of sodium.
Aim of study: The aim of study was to compare natremia with selected blood parameters determined on admission to hospital, and then to find correlation, if any, between those parameters.
Materials and methods: We retrospectively reviewed the medical records of 169 patients with diagnosed type 2 diabetes and the average age of 72.43±11.62 years. We tested the correlation between natremia and: total, LDL and HDL cholesterol; creatinine; potassium; calcium; eGFRCKD-EPI and alanine aminotransferase levels in the patients. Statistical analysis was run on STATISTICA 13. The nonparametric Mann-Whitney, Spearmans’ rank correlation and the Shapiro-Wilk tests were used to analyse factors affecting laboratory test results for the patients, perform correlation analyses and check the conformity with normal distribution, respectively.
Research results: A positive correlation was revealed between LDL level and natremia (p = 0.023), as well as between natremia and chloride ion concentration (p < 0.001) in the patients’ blood. No correlation was found between natremia and sex, age, eGFRCKD-EPI, alanine aminotransferase, HDL cholesterol, triglycerides, creatinine, as well as calcium and potassium concentrations.
Conclusions: Statistically significant correlations were found exclusively between LDL level and natremia, and between chloride and sodium concentrations. High LDL level was correlated with high natremia, which requires further research due to the scant literature. The sodium, potassium and chloride concentrations are known to be interconnected by the need to ensure the electrolyte balance, as seen in the Gamble diagram. The remaining parameters were not statistically significant.
Enhancing Critical Thinking Skills and Media Literacy in Initial VET Students: A Mixed Methods Study on a Cross-Country Training Program
Authors: Tommasi Francesco , Ceschi Andrea , Bollarino Sara , Belotto Silvia , Genero Silvia , Sartori Riccardo 
Published: July 2023

Context: In the last few decades, the constant and exponential changes in the society's consumption of information have increased the awareness of practitioners from the education and training field, on the need for training programs for the enhancement of critical thinking skills and media literacy among students from Initial Vocational Education and Training (IVET) who are less exposed to intellectual trainings than their peers in traditional education pathways.
Approach: With this impetus, the present paper reports the results of a mixed methods study evaluating a training program for such competences. Based on a cognitive psychology theoretical framework, the training program consisted in three main techniques through which trainers can work with students in the classroom. N= 35 trainers from five different countries (i.e., Greece, Italy, Spain, Portugal, and the Netherlands) were instructed about the training techniques and implemented them in their training centres. Then, a total of N= 288 students among these countries were involved in the testing of the training, which took place on a duration average of 5 months. Mixed methods approach was used to evaluate the effectiveness and quality of the training. Notably, prospective statistical analysis evaluated the training's impact of the participating students and compared with a control group. Qualitative interviews examined the training's lived experience with a group of students and trainers.
Findings: The quantitative and qualitative analysis of pre/post- measures of critical thinking skills and media literacy of the experimental group, and the comparison with the control group, indicate an increase in these competences and confirm the efficacy of the training intervention.
Conclusion: These results inform about the usefulness of the training program cross-culturally and the feasibility of training strategies based on cognitive psychology. Moreover, the paper offers a methodological contribution thanks to the proposition of the mixed methods approach for training programs assessment.
Design and testing of star tracker algorithms for autonomous optical line-of-sight deep-space navigation
Authors: Casini Stefano , Cervone Angelo , Monna Bert , Visser Pieter 
Published: July 2023

This paper aims to investigate the capabilities of exploiting optical line-of-sight navigation using star trackers. First, a synthetic image simulator is developed to generate realistic images, which is later exploited to test the star tracker’s performance. Then, generic considerations regarding attitude estimation are drawn, highlighting how the camera’s characteristics influence the accuracy of the estimation. The full attitude estimation chain is designed and analyzed in order to maximize the performance in a deep-space cruising scenario. After that, the focus is shifted to the actual planet-centroiding algorithm, with particular emphasis on the illumination compensation routine, which is shown to be fundamental to achieving the required navigation accuracy. The influence of the center of the planet within the singular pixel is investigated, showing how this uncontrollable parameter can lower performance. Finally, the complete algorithm chain is tested with the synthetic image simulator in a wide range of scenarios. The final promising results show that with the selected hardware, even in the higher noise condition, it is possible to achieve a direction’s azimuth and elevation angle error in the order of 1–2 arc sec for Venus, and below 1 arc sec for Jupiter, for a spacecraft placed at 1 AU from the Sun. These values finally allow for a positioning error below 1000 km, which is in line with the current non-autonomous navigation state-of-the-art.
Impact of preventive chemotherapy on Strongyloides stercoralis: A systematic review and meta-analysis
Authors: Stroffolini Giacomo , Tamarozzi Francesca , Fittipaldo Andrea , Mazzi Cristina , Le Brandon , Vaz Nery Susana , Buonfrate Dora 
Published: July 2023

Background
Strongyloides stercoralis is a neglected soil-transmitted helminth (STH) that leads to significant morbidity in endemic populations. Infection with this helminth has recently been recognised by the World Health Organization (WHO) as a major global health problem to be addressed with ivermectin preventive chemotherapy, and therefore, there is now, the need to develop guidelines for strongyloidiasis control that can be implemented by endemic countries. This study aimed to evaluate the impact of ivermectin preventive chemotherapy (PC) on S. stercoralis prevalence in endemic areas to generate evidence that can inform global health policy.

Methodology/Principal findings
This study was a systematic review and meta-analysis. We searched PubMed, EMBASE, Cochrane Central Register of Controlled Trials, and LILACS for literature published between 1990 and 2022 and reporting prevalence of S. stercoralis before and after PC with ivermectin, administered either at school or at community level. The search strategy identified 933 records, eight of which were included in the meta-analysis. Data extraction and quality assessment were carried out by two authors. Meta-analysis of studies based on fecal testing demonstrated a significant reduction of S. stercoralis prevalence after PC: prevalence Risk Ratio (RR) 0.18 (95% CI 0.14–0.23), I2 = 0. A similar trend was observed in studies that used serology for diagnosis: RR 0.35 (95% CI 0.26–0.48), I2 = 4.25%. A sensitivity analysis was carried out for fecal tests where low quality studies were removed, confirming a post-intervention reduction in prevalence. The impact of PC could not be evaluated at different time points or comparing annual vs biannual administration due to insufficient data.

Conclusions/Significance
Our findings demonstrate a significant decrease of S. stercoralis prevalence in areas where ivermectin PC has taken place, supporting the use of ivermectin PC in endemic areas.
Construction and validation of 3-genes hypoxia-related prognostic signature to predict the prognosis and therapeutic response of hepatocellular carcinoma patients
Authors: Liu Yunxun , Shen Bingbing , Huang Ting , Wang Jianguo , Jiang Jianxin 
Published: July 2023

Background
Previous studies have shown that the hypoxia microenvironment significantly impacted tumor progression. However, the clinical prognostic value of hypoxia-related risk signatures and their effects on the tumor microenvironment (TME) in hepatocellular carcinoma (HCC) remains hazy. This study aimed to conduct novel hypoxia-related prognostic signatures and improve HCC prognosis and treatment.

Methods
Differentially expressed hypoxia-related genes (HGs) were identified with the gene set enrichment analysis (GSEA). Univariate Cox regression was utilized to generate the tumor hypoxia-related prognostic signature, which consists of 3 HGs, based on the least absolute shrinkage and selection operator (LASSO) algorithm. Then the risk score for each patient was performed. The prognostic signature’s independent prognostic usefulness was confirmed, and systematic analyses were done on the relationships between the prognostic signature and immune cell infiltration, somatic cell mutation, medication sensitivity, and putative immunological checkpoints.

Results
A prognostic risk model of four HGs (FDPS, SRM, and NDRG1) was constructed and validated in the training, testing, and validation datasets. To determine the model’s performance in patients with HCC, Kaplan–Meier curves and time-dependent receiver operating characteristic (ROC) curves analysis was implemented. According to immune infiltration analysis, the high-risk group had a significant infiltration of CD4+ T cells, M0 macrophages, and dendritic cells (DCs) than those of the low-risk subtype. In addition, the presence of TP53 mutations in the high-risk group was higher, in which LY317615, PF−562271, Pyrimethamine, and Sunitinib were more sensitive. The CD86, LAIR1, and LGALS9 expression were upregulated in the high-risk subtype.

Conclusions
The hypoxia-related risk signature is a reliable predictive model for better clinical management of HCC patients and offers clinicians a holistic viewpoint when determining the diagnosis and course of HCC treatment.