bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lean service: a contingency perspective
Authors: Fenner Sophie , Netland Torbjørn 
Published: February 2023

AbstractMany firms launch consolidated lean initiatives across all their service units, but because services differ, mandated lean practices may have a poor fit with the receiving unit. Whereas plenty of research has investigated the fit of lean implementation at the service industry level, this is the first to delineate how standard lean service practices fit different service types. Taking a contingency theory perspective, we study a leading European utility company comprising distinct service types. Using purposeful sampling, we interview 36 employees from 15 different teams representing three different service types – professional services, service factories and service shops – and 11 employees from the headquarters who are supporting these units in their lean transformation journeys. We also collect secondary data, including lean programme documentation and audit data. We find that one size does not fit all for lean service; there are important nuances to the relevance of standard lean service practices across different service types. Ten propositions are put forward suggesting how standard lean practices need to be adapted to fit the context of different service types. The findings reject the idea that all service units can progress along the same trajectory in lean service programmes. This paper informs managers how lean service programmes can be tailored to increase the fit with different service types.
Pretreatment of Grape Pomaces and Stalks Using Deep Eutectic Solvents for Succinic Acid Production Integrated in a Biorefinery Concept
Authors: Filippi Katiana , Stylianou Eleni , Pateraki Chrysanthi , Koutinas Apostolis , Ladakis Dimitrios 
Published: February 2023

AbstractDeep eutectic solvents (DES) have been employed for the pretreatment of grape pomace and stalks within a biorefinery concept. Four DES, produced with choline chloride (ChCl) as hydrogen bond acceptor and four carboxylic acids as hydrogen bond donors, namely formic acid (FA), acetic acid (AA), lactic acid (LA) and oxalic acid (OA), were evaluated considering lignin removal efficiency, polysaccharide hydrolysis efficiency into C5 and C6 sugars, recyclability and reusability. The mixture of ChCl:LA at 1:10 molar ratio, 120°C and 1 h pretreatment, led to 40% lignin removal over four pretreatment cycles. Enzymatic hydrolysis of the remaining solids after the first pretreatment cycle resulted in 92.7% glucan and 36.6% hemicellulose hydrolysis yield. The hydrolysate was used as fermentation feedstock in batch Actinobacillus succinogenes bioreactor cultures leading to 36 g/L succinic acid with a yield of 0.62 gSA per g total sugars and 0.65 g/(L⋅h) productivity. Using 2 kg of grape pomace and stalks in each pretreatment cycle, the succinic acid that could be produced in five consecutive cycles is 200.8 g, 208 g, 204.9 g, 184.5 g and 94.3 g.

Graphical Abstract
Trench visualisation from a semiautonomous excavator with a base grid map using a TOF 2D profilometer
Authors: Niskanen Ilpo , Immonen Matti , Makkonen Tomi , Hallman Lauri , Mikkonen Martti , Keränen Pekka , Kostamovaara Juha , Heikkilä Rauno 
Published: February 2023

Abstract
Real-time, three-dimensional (3D) visualisation technology can be used at construction sites to improve the quality of work. A 3D view of the landscape under work can be compared to a target 3D model of the landscape to conveniently show needed excavation tasks to a human excavator operator or to show the progress of an autonomous excavator. The purpose of this study was to demonstrate surface visualisation from measurements taken with a pulsed time-of-flight (TOF) 2D profilometer on-board a semiautonomous excavator. The semiautomatic excavator was implemented by recording the feedback script parameters from the work performed on the excavator by a human driver. 3D visualisation maps based on the triangle mesh technique were generated from the 3D point cloud using measurements of the trenches dug by a human and an autonomous excavator. The accuracy of the 3D maps was evaluated by comparing them to a high-resolution commercial 3D scanner. An analysis of the results shows that the 2D profilometer attached to the excavator can achieve almost the same 3D results as a high-quality on-site static commercial 3D scanner, whilst more easily providing an unobstructed view of the trench during operation (a 3D scanner placed next to a deep trench might not have a full view of the trench). The main technical advantages of our 2D profilometer are its compact size, measurement speed, lack of moving parts, robustness, low-cost technology that enables visualisations from a unique viewpoint on the boom of the excavator, and readiness for real-time control of the excavator’s system. This research is expected to encourage the efficiency of the digging process in the future, as well as to provide a remarkable view of trench work using an excavator as a moving platform to facilitate data visualisation.

Graphical abstract
At-home assessment of postural stability in parkinson’s disease: a vision-based approach
Authors: Ferraris Claudia , Votta Valerio , Nerino Roberto , Chimienti Antonio , Priano Lorenzo , Mauro Alessandro 
Published: February 2023

AbstractPostural instability is one of the most disabling symptoms of Parkinson’s Disease, with important impacts on people safety and quality of life since it increases the risk of falls and injuries. Home monitoring of changes in postural stability, as a consequence of therapies and disease progression, is highly desirable for the safety of the patient and better disease management. In this context, we present a system for the automatic evaluation of postural stability that is suitable for self-managing by people with motor impairment directly at home. The system is based on an optical RGB-Depth device, which tracks the body movements both for system’s interaction, thanks to a gesture-based human-machine interface, and the automated assessment of postural stability. A set of tasks, based on standard clinical scales, has been designed for the assessment. The user controls the delivery of the tasks through the system interface. A machine learning approach is adopted, and some kinematic parameters that characterize the user’s performance during each task execution are estimated and used by supervised classifiers for the automatic assessment. Data collected during experimental clinical trials were used to train the classifiers. This approach supports the compliance of the classifier assessments with respect to the clinical ones. The system prototype and the preliminary results on its accuracy in the assessment of postural stability are presented and discussed.
Is it time for redefining oligometastatic disease? Analysis of lung metastases CT in ten tumor types
Authors: Gofrit Ofer N. , Gofrit Ben , Roditi Yuval , Popovtzer Aron , Frank Steve , Sosna Jacob , Goldberg S. Nahum 
Published: February 2023

Abstract
Background
Oligometastatic disease (OD) is usually defined arbitrarily as a condition in which there are ≤ 5 metastases. Given limited disease, it is expected that patients with OD should have better prognosis compared to other metastatic patients and that they can potentially benefit from metastasis-directed therapy (MDT). In this study, we attempted to redefine OD based upon objective evidence that fulfill these assumptions.

Methods
Chest CTSs of 773 patients with 15,947 lung metastases originating from ten malignancy types were evaluated. The number and largest diameter of each metastasis was recorded. Metastatic cluster was defined as a cluster of two or more metastases with diameter difference ≤ 1 mm. The prognostic power of seven statistical models on overall survival (OS) was analyzed.

Findings
Both the number of metastases and metastatic clusters had a highly significant impact on OS (p < 0.0001, p = 0.003 respectively). Patients with a single metastasis or a single cluster of metastases (regardless of metastases number), equaling 16.2% of all patients, had significantly better prognosis compared to other patients (p = 0.0002). If metastases diameter variability is ignored, as in the standard definition of OD, then patients with 2–5 and 6–10 metastases would have a similar prognosis.

Interpretation
Patients with a single cluster of metastases, theoretically originating from a single clone, have significantly better prognosis compared to patients with more than one cluster. Using this definition can potentially improve the results of MDT. The upper limit of metastases number should be determined by the technical capabilities of the MDT used.
Engaging Stigmatised Communities in Australia with Digital Health Systems: Towards Data Justice in Public Health
Authors: Smith Anthony K J , Davis Mark D. M. , MacGibbon James , Broady Timothy R. , Ellard Jeanne , Rule John , Cook Teddy , Duck-Chong Elizabeth , Holt Martin , Newman Christy E. 
Published: February 2023

Abstract
Introduction
In 2018, following government policy changes to Australia’s national electronic health record system, ‘My Health Record’, consumer advocates—including organisations representing people living with HIV, people who use drugs and sex workers—raised concerns about privacy and data security. Responding to these controversies, this study explores the practical, ethical and political complexities of engaging stigmatised communities with digital health systems.

Methods
We conducted 16 qualitative semi-structured interviews in 2020 with key informants representing communities who experience stigma, discrimination and marginalisation in Australia. These communities included people living with HIV, sex workers, people who inject drugs, gay and bisexual men and transgender and gender diverse people. We conducted a reflexive thematic analysis.

Results
Key informants were sceptical of proposed benefits of electronic health records for their communities, and concerned about privacy risks and the potential for discrimination. Meaningful consultation, consent mechanisms and tackling structural stigma were raised as solutions for engaging communities.

Conclusions
Although communities could benefit from being included in digital health systems, significant cultural, legal and social reforms from government were believed to be necessary to build trust in digital health systems. We argue that these forms of data justice are necessary for effective future systems.

Policy Implications
Engaging stigmatised communities—including in relation to gender, sexuality, sex work, drug use, HIV—requires a commitment to data justice. The design and implementation of digital health systems requires investment in ongoing and meaningful consultation with communities and representative organisations.
Current controversies on mechanisms controlling soil carbon storage: implications for interactions with practitioners and policy-makers. A review
Authors: Derrien Delphine , Barré Pierre , Basile-Doelsch Isabelle , Cécillon Lauric , Chabbi Abad , Crème Alexandra , Fontaine Sébastien , Henneron Ludovic , Janot Noémie , Lashermes Gwenaëlle , Quénéa Katell , Rees Frédéric , Dignac Marie-France 
Published: February 2023

AbstractThere is currently an intense debate about the potential for additional organic carbon storage in soil, the strategies by which it may be accomplished and what the actual benefits might be for agriculture and the climate. Controversy forms an essential part of the scientific process, but on the topic of soil carbon storage, it may confuse the agricultural community and the general public and may delay actions to fight climate change. In an attempt to shed light on this topic, the originality of this article lies in its intention to provide a balanced description of contradictory scientific opinions on soil carbon storage and to examine how the scientific community can support decision-making despite the controversy. In the first part, we review and attempt to reconcile conflicting views on the mechanisms controlling organic carbon dynamics in soil. We discuss the divergent opinions about chemical recalcitrance, the microbial or plant origin of persistent soil organic matter, the contribution of particulate organic matter to additional organic carbon storage in soil, and the spatial and energetic inaccessibility of soil organic matter to decomposers. In the second part, we examine the advantages and limitations of big data management and modeling, which are essential tools to link the latest scientific theories with the actions taken by stakeholders. Finally, we show how the analysis and discussion of controversies can guide scientists in supporting stakeholders for the design of (i) appropriate trade-offs for biomass use in agriculture and forestry and (ii) climate-smart management practices, keeping in mind their still unresolved effects on soil carbon storage.
A unified and modular coupling of particle methods with fem for civil engineering problems
Authors: Flores Carlos Eulogio , Sautter Klaus Bernd , Bucher Philipp , Cornejo Alejandro , Franci Alessandro , Bletzinger Kai-Uwe , Wüchner Roland 
Published: February 2023

AbstractIn this work, a modular coupling approach for particle methods with the FEM (finite element method) is presented. The proposed coupled strategy takes advantage from the ability of particle methods of dealing with large displacements and deformations, especially when solving complex fluid–structure and solid–structure interaction problems. The coupling between the FEM and particle methods is done using a co-simulation approach implemented in the open-source Kratos Multiphysics framework. The particle methods considered in this work are the DEM (discrete element method) and the PFEM (particle finite element method). The Lagrangian description of the PFEM is well suited for modeling fluids undergoing large deformations and free-surface motions, and the DEM can be used to simulate rocks, debris and other solid objects. To accelerate the convergence of the coupled strategy, a block Gauss–Seidel algorithm with Aitken relaxation is used. Several numerical examples, with an emphasis on natural hazards, are presented to test and validate the proposed coupled method.
The short-term impact of the COVID-19 pandemic on the management of private universities in Poland
Authors: Geryk Marcin 
Published: February 2023

AbstractIn early March 2020, the COVID-19 pandemic changed the situation of thousands of higher education institutions around the world. The spreading virus not only imposed remote education, but it also brought tremendous changes in university management. The introduction of new educational and administrative solutions was a huge logistical and financial challenge for public and private universities. It was not easy for students either. It also posed a problem for the faculty. Remote learning generated many problems even in highly developed countries. Therefore, the number of students was expected to slowly decline. It was a surprise that private universities saw an increase in interest in their offer right after the outbreak of the pandemic. The article presents the situation of private universities in Poland, the complex problems related to the management of the academic environment in the absence of proper preparation for on-line education as well as for remote management of higher education organizations.
“Wood-nacre”: Development of a Bio-inspired Wood-Based Composite for Beam and 3D-Surface Elements with Improved Failure Mechanisms
Authors: Müller Ulrich , Halbauer Peter , Stadlmann Alexander , Grabner Maximilian , Al-musawi Hajir , Ungerer Bernhard , Pramreiter Maximilian 
Published: February 2023

AbstractFollowing the natural structure of the nacre, the material studied consists of a multitude of hexagonal tiles that are glued together in an offset manner with a ductile adhesive. This so-called “wood nacre” consists of macroscopic tiles of birch wood veneer with a thickness of 0.8 mm and a size of 20 or 10 mm in diameter in order to mimic the aragonite tiles and the ductile PUR-adhesive corresponds to the layers of collagen in between. E-modulus (MOE), bending strength (MOR) and impact bending strength of the samples were determined and compared with reference samples of birch laminated wood. The hierarchical layered structure of the tiles does not cause any relevant loss in stiffness. Like nacre, “wood nacre” also shows tough fracture behaviour and a high homogenization effect. However, strain hardening and high fracture toughness of the natural model could not be fully achieved. The reason for this is the insufficient ratio between the strength and stiffness of the veneer layers and the adhesive. By adjusting the size of the tiles, increasing the strength and surface roughness of the veneers, e.g. by densification, and using more ductile adhesives that can be applied in smaller layer thicknesses, it should be possible to better reproduce the natural ratios of nacre and thus achieve a significant improvement in the material properties of “wood nacre”. In addition to the mechanical properties, the high potential of the new material lies in the possibility of producing 3D shell-shaped elements for lightweight wood hybrid construction.
Targeted therapy, immunotherapy, and chemotherapy for chordoma
Authors: Yang Xue , Li Parker , Kang Zhuang , Li Wenbin 
Published: February 2023

AbstractChordoma is a rare bone tumor often present in the skull base and spine. In addition, it is not sensitive to radiotherapy that surgical resection is of great significance for the treatment of chordoma. Residual tumors that cannot be surgically removed usually lead to tumor recurrence. Studies have shown that chordoma will be accompanied by multiple gene mutations, such as PDGFR, EGFR, HER2, VEGFR, and mTOR, and interact with the host immune system to promote tumor progression. Targeted therapy and immunotherapy can improve the prognosis of chordoma patients to some extent. This review focuses on the clinical trials related to targeted therapy, immunotherapy, and chemotherapy of chordoma.
What is the global glacier ice volume outside the ice sheets?
Authors: Hock Regine , Maussion Fabien , Marzeion Ben , Nowicki Sophie 
Published: February 2023

AbstractA recent study (Millan and others, 2022a, Nature Geoscience 15(2), 124–129) claims that ice volume contained in all glaciers outside the ice sheets and its potential contribution to sea level is 20% less than previously estimated. However, the apparent decrease is largely due to differences in choice of domain, as the study excludes 80% of the glacier area in the Antarctic periphery that was included in previous global glacier volume estimates. The issue highlights the difficulty in separating glaciers from the ice-sheet proper, especially in Antarctica, and the need for both the glacier and ice-sheet communities to develop standards and protocols to avoid double-counting in global ice volume and mass-change assessments and projections. Process-based inversion models have replaced earlier scaling methods, but large uncertainties in global glacier volume estimation remain due to the ill-posed nature of the inversion problem and poorly constrained parameters emphasizing the need for more direct ice thickness observations.
Biochanin A in murine Schistosoma mansoni infection: effects on inflammation, oxidative stress and fibrosis
Authors: Elhenawy A.A. , Elmehankar M.S. , Nabih N. , Elzoheiry M.A. , Hany H. , El-Gamal R. , Aboukamar W.A. 
Published: February 2023

Abstract
Biochanin A (BCA) is a multifunctional natural compound that possesses anti-infective, anti-inflammatory, anti-oxidative and hepatoprotective effects. The aim of the study was to assess the therapeutic efficacy of BCA on Schistosoma mansoni-infected mice. Fifty mice were divided into six different groups as non-infected, non-infected BCA-treated, infected untreated, early infected BCA-treated (seven days post-infection (dpi)), late infected BCA-treated 60 dpi and infected praziquantel (PZQ)-treated groups. Parasitological, histopathological examination and immunohistochemical staining of transforming growth factor (TGF)-β, inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX-2) were investigated in liver sections. Cytochrome P450 (CYP450) gene expression of S. mansoni was evaluated by quantitative real-time polymerase chain reaction (RT-qPCR). A single dose of BCA significantly reduced worm burden in early (82.14%) and late infection (77.74%), mean tissue egg load in early (7.27 ± 0.495) and late BCA administration (7.63 ± 0.435) and decreased granuloma size. CYP450 mRNA expression was significantly reduced in early BCA treatment as compared to late treatment which emphasizes that early administration of BCA had more pronounced effects on worms than late administration. Both early and late BCA administration led to significant reduction in inflammatory cytokines as TGF and iNOS. Although the reduction of TGF and iNOS in BCA-treated mice was superior to PZQ, no statistically significant differences were noted. However, a significant downregulation of COX2 was noted in hepatocytes as compared to both infected control and PZQ-treated mice. BCA has schistosomicidal, anti-inflammatory, antioxidant and anti-fibrotic effects and could be regarded as a potential drug in schistosomiasis treatment.
Biological parameters of grey wrasse Symphodus cinereus (Bonnaterre, 1788) (Pisces: Labridae) along the coasts of Rize in the south-eastern Black Sea
Authors: Onay Hatice 
Published: February 2023

Abstract
The present study was designed to investigate the age distribution and growth properties of Symphodus cinereus in the south-eastern Black Sea. Data on the growth and age of S. cinereus were obtained by investigating sagittal otoliths. A total of 384 specimens (220 female, 164 male) were collected between June 2015 and May 2016 in the south-eastern Black Sea. Total lengths of male specimens ranged from 10–16.4 cm, whereas they ranged from 8.2–15.8 cm for females. The von Bertalanffy growth curve was used to describe length at age and considerable differences were seen between females (t0 = −2.85, k = 0.296 and L∞ = 16.46 cm) and males (t0 = −2.84, k = 0.272 and L∞ = 17.23 cm). The maximum age was 5 years. The relationship for males was W = 0.009L3.2596 (r2 = 0.9174, P < 0.005) and that for females was W = 0.0011L3.1821 (r2 = 0.9012, P < 0.005). While the highest condition (K) value was calculated in spring, the lowest value was determined in winter for both sexes. The obtained data also revealed monthly changes in the gonadosomatic index and maturity stages of male and female specimens, and the annual spawning season of this population began in March and ended in June. Fecundity ranged between 1375 and 5493 eggs/individual (mean: 2868.11 ± 36–59.69 eggs), and the relationship between total length and egg production was highly statistically significant (P < 0.0001). This study provides the first data on the growth and reproduction of S. cinereus along the south-eastern Black Sea coast of Turkey.
Administrative Burdens in Chinese Public Services: A Case of Selective Affinity
Authors: Wang Ou , Qi Dongtao , Liu Yangge 
Published: February 2023

AbstractThe non-take-up of public services has the potential to undermine civil rights and deepen social inequality. Looking at the case of the Youth Community College Programme in China, an innovation in governance to facilitate community integration of the migrant population by providing free education, this study finds that the targeted disadvantaged groups are systematically excluded due to the disproportionate imposition of various administrative burdens on them. We propose that an interaction mechanism – which we term “selective affinity” – between the policy process and individuals’ human capital leads to this unintended outcome. The study contributes to a deeper understanding of the causal mechanisms underlying vulnerable people's non-take-up of public services, while highlighting an example of dysfunctional state–society interaction and a mechanism for the reproduction of social inequality under authoritarianism in China.