bluuebunny/crossref_metadata_2025_split huggingface dataset:
When tracheotomy was the only resort in paediatric tracheo-bronchial foreign body: case report
Authors: Munjal Manish , Gupta Shikha , Kathuria Suneet , Pooni Puneet , Munjal Shubham , Talwar Shivam , Chawla Deeksha , Kaur Hardeep , Bharadwaj Iti , Arora Anurima , Mehta Devambika 
Published: January 2023

The pediatric individual is likely to present with an aspirated foreign body that maybe oriented as such that it may necessitate often an alternate route for removal. Rigid bronchoscopy with jet ventilation is the intervention undertaken at the earliest. In wide caliber foreign bodies a different approach has to be adopted. Tracheotomy, thoracotomy, bronchotomy and pneumonectomy are the next level procedures. A cervical tracheostomy had to be undertaken in a child with a week old impacted conical tail cap of a ball point pen.
A case of sudden death due to pulmonary embolism of bone marrow origin, masked as acute drug toxicity: A rare case in a bewildering clinical scenario
Authors: Bandyopadhyay Chandan , Nandi Ayandip , Mukherjee Archita 
Published: January 2023

Sudden death is unexpected death within 24 hours from the onset of symptoms with or without known preexisting conditions. Respiratory pathologies are the second most common cause of such deaths. 39 years old male patient with a history of mental illness for the last 10 years and on regular treatment with antipsychotic medications, suffered sudden deterioration of higher functions and was admitted to the Medical College, and Hospital, Kolkata with a provisional diagnosis of drug toxicity. He succumbed to his condition within 24 hours of admission and the dead body was referred to Kolkata Police Morgue for a medicolegal autopsy.Shows multi-system involvement in the form of Pulmonary Oedema, consolidation, broncho-pneumonic changes and subpleural petechiae, Cardiomegaly due to biventricular hypertrophy, Cerebral Oedema, Enlarged kidneys with loss of cortico-medullary differentiation and streaky cortico-medullary haemorrhages. Stomach findings were unremarkable.1) Toxicological Examination of blood, bile, vitreous and routine viscera was negative for any poison or pharmacological agents.2)Histopathological examination with routine H&E staining showed Pulmonary oedema with lymphocytic infiltration and the presence of fat and hematopoietic precursor cells in pulmonary vessels, Interstitial Oedema and focal glomerulosclerosis and Periportal inflammation in the liver.
The Effect of Weather Parameters on Yield Performance of Some Aromatic Rice Cultivars (Oryza sativa L.) of Manipur
Authors: Hanglem Ionebala Devi , Vivekananda Yaikhom , Singh R.K. Imotomba , Sarma Satya 
Published: January 2023

Background: The primary objective of the study was to find out the effect of Weather parameters on the Chakhao production. Reports postulated that crop productivity is impacted by agricultural practises rather than climate. However, yield is very much dependent on environmental and cultural conditions which are less studied and not yet defined. Since Chakhao is traditionally a low yielding crop of Manipur. Despite of being their great values in nutrition, medicinally and economically, the farmers of Manipur neglect the cultivation of the black scented rice in large scale due its low yield. Thus, the current study was taken to have a better understanding of the growth and yield with effect to weather parameters of the three Chakhao cultivars viz. Poireiton, Amubi, Angouba. Methods: The present investigation was conducted to study the effect of various weather parameters on growth and yield of black scented and aromatic rice cultivars of Manipur. During this study, three local rice cultivars of Manipur was cultivated in kharif crop season (June -July to November-December) during the year 2019 , 2020 and 2021 at PDDUIAS, Research farm of Utlou, Manipur. The experimental field is located at 24°43‘78”N Latitude, 93°51‘60”E Longitude and the elevation or altitude of 2513 feet above mean sea level. During these experiments different major growth stages were recorded, while all other input parameters were kept constant. For this study the spacing adopted was 25 cm x 25 cm. After harvesting, the agro-morphological characters compared to analyse the effect of weather parameters were Temperature, Relative Humidity, Rainfall and Wind speed for the period of 3 years i.e., 2019, 2020, 2021. Result: It was observed that the rice variety Chakhao Angouba resulted the highest yield followed by Chakhao Poireiton and Chakhao Amubi. The correlation between weather parameters and agro-morphological growth and yield related parameters were estimated by Pearson correlation coefficient and degree of dependencies of these agro-morphological parameters on weather parameters were analysed by using linear regression analysis. All the yield attributing characters i.e., number of panicles per plant, number of grains per panicle and 1000 grain weight (g) were taken but they do not showed significant correlation except average rainfall and the number of leaves.
GOD SPOT DAN TATANAN NEW NORMAL DI TENGAH PANDEMI COVID-19
Authors: Fitriyana Nur 
Published: January 2023

Penyebaran Covid-19 sulit untuk diputus, sebab proses mutasinya begitu cepat dan dapat menimbulkan varian baru. Sehingga sulit untuk membuat vaksin. Banyak orang mengharapkan herd imunity yang diperlukan menuju tatanan new normal. Agama memiliki peran signifikan sebagai penguat bagi manusia dalam menjalani berbagai tantangan kehidupan yang tidak biasa, khususnya di masa pandemi dan menuju tatanan new normal. Jelasnya, muncul beragam sikap dan prilaku masyarakat beragama. Nada pesimis terhadap agama bahkan terhadap Tuhan juga muncul. Jangankan mengatakan wabah sebagai azab Tuhan karena kejahatan sudah merajalela. Bahkan dengan Tuhan pun mereka tidak percaya. Sehingga tulisan ini urgen sebagai bagian dari solusi dalam menghadapi pandemi covid-19 dan menuju new normal. Sebagai manusia yang beragama, sudah seharusnya menghadapi pandemi ini secara holistik, tidak cukup dengan pendekatan parsial dari segi medis, tetapi juga dengan pendekatan agama.
Penelitian ini menghasilkan temuan bahwa dalam menuju tatanan new normal perlu mensinergikan kekuatan agama dan sains. Karena agama bertugas menemukan makna dan sains bertugas menemukan fakta. Sehingga bukan hanya menjalankan protokol kesehatan saja tetapi juga perlu mengaktifkan titik God Spot yang mengembalikan manusia kepada kesucian fitrahnya untuk memperkuat mentalitas dan konsep diri dalam menghadapi tatanan new normal. Kepatuhan dan ketaatan kepada Allah, keihklasan, kesabaran dan ketabahan menghadapi pandemi covid-19 bersinergi dengan kesadaran kolektif berbasis keluarga untuk tetap sehat, yaitu mencuci tangan dengan air dan sabun yang mengalir, memakai masker ketika ke luar rumah, menjaga jarak, menjaga pola makan dan berolahraga untuk menjaga imun supaya tetap sehat. Suasana kecemasan, karena ketakutan pada virus corona perlahan mulai hilang seiring dengan doa yang senantiasa dipanjatkan kepada Sang Penguasa Tunggal. Sehingga suasana batin yang tenang ini justru dapat meningkatkan imunitas tubuh. Sejatinya menjalankan protokol kesehatan adalah bagian dari menjalankan ajaran agama.
ANTESEDEN DARI EMPLOYEES’ ENGAGEMENT: SEBUAH MODEL MODERATED MEDIATION DARI PERCEIVED ALTERNATIVE JOB OPPORTUNITIES, EMPLOYEES’ ATTITUDE DAN EMPLOYEES’ MOTIVATION DOSEN DI UNIVERSITAS “X” [THE ANTECEDENTS OF EMPLOYEES’ ENGAGEMENT: A MODERATED MEDIATION MODEL OF LECTURER’S PERCEIVED ALTERNATIVE JOB OPPORTUNITIES, EMPLOYEES’ ATTITUDE AND EMPLOYEES’ MOTIVATION AT “X” UNIVERSITY ]
Authors: Indrawan Indrawan 
Published: January 2023

<strong>Abstract </strong><p class="abstrak"><span lang="EN-US">This study aims to investigate the role and potential of mediating and moderating variables which are the antecedents for Employees' Engagement (EE) at University “X” by developing and testing an empirically integrated model to study the mediating role of Employees' Attitude (EA) and Employees' Motivation (EM) on the relationship between Transformational Leadership (TL) and EE being moderated by Perceived Alternative Job Opportunities (PAJO). This study uses a quantitative research approach with survey research methods (non-experimental). The data collection method was carried out through an E-questionnaire for 98 lecturers at the "X" university. Data is analyzed using PLS-SEM resulting in PAJO does not moderate the mediation of EA and EM between TL and EE.</span></p><p class="abstrak"> </p><p class="abstrak"><strong>Bahasa Indonesia Abstrak </strong></p><p>Penelitian ini bertujuan untuk mempelajari peran dan potensi variabel mediasi dan moderasi yang merupakan anteseden bagi <em>Employees’ Engagement</em> (EE) di universitas “X” dengan mengembangkan dan menguji sebuah model yang terintegrasi secara empiris untuk mempelajari peran mediasi <em>Employees’ Attitude </em>(EA) dan <em>Employees’ Motivation </em>(EM) terhadap hubungan <em>Transformasional Leadership </em>(TL) dan EE yang dimoderasi oleh <em>Perceived Alternative Job Opportunities </em>(PAJO)<em>.</em> Penelitian ini menggunakan pendekatan penelitian kuantitatif dengan metode penelitian survey (non-eksperimental). Metode pengumpulan data dilakukan melalui E-kuesioner terhadap 98 dosen di universitas “X”. Analisis Data menggunakan PLS SEM dimana hasil penelitiannya adalah PAJO tidak memoderasi hubungan TL dan EE yang dimediasi oleh EA dan EM.</p>
Prinsip Pembacaan Akta Oleh Notaris Dihadapan Penghadap dan Saksi
Authors: Dewi Maya Puspita , Poesoko Herowati , Harianto Aries 
Published: January 2023

Pembacaan akta oleh notaris merupakan hal yang penting karena banyak kepentingan yang terkait didalamnya. Pembacaan akta dimaksudkan untuk memastikan bahwa akta otentik yang dibuat oleh Notaris sesuai dengan keinginan atau kehendak para penghadap yang membuat akta. Adanya pengecualian dalam pengaturan mengenai pembacaan akta dalam UUJN , dapat dijadikan tameng untuk tidak melakukan pembacaan akta seperti yang diamanatkan dalam Pasal 16 ayat 1 huruf m UUJN. Hal ini tentu saja akan berdampak pada besarnya kemungkinan terjadi konflik hukum diwaktu yang akan datang. Penelitian ini merupakan penelitian yuridis normatif dengan menggunakan 3 (tiga) pendekatan yaitu pendekatan perundang-undangan, pendekatan konseptual dan pendekatan sejarah. Hasil dari penelitian adalah bahwa Ratio Legis dari pengaturan mengenai Kewajiban Pembacaan Akta yang mewajibkan Notaris untuk membacakan akta didasari pada landasan filosofis dari pembentukan Undang-Undang tersebut, yang secara eksplisit dinyatakan dalam Pasal 3 UUD NRI 1945, bahwa Negara menjamin kepastian dan perlindungan hukum yang berintikan kebenaran dan keadilan terwujud didalam masyarakat. Akan tetapi beragam kepentingan yang melatarbelakangi pembentukan undang-undang mengenai pengaturan kewajiban pembacaan Akta tersebut, menjadikan peraturan ini tidak konsististen yang berakibat tidak adanya kepastian hukum didalamnya.
Analisis Kualitas Selai Organik Dari Buah Mengkudu Sebagai Produk Bisnis Skala Rumahan
Authors: Tania Adila  , Novsa Fakhira  
Published: January 2023

Abstract
Noni is one of the most abundant fruits in Indonesia. Noni trees that bear fruit every season need to be further processed to reduce the amount of fruit wasted. In addition, the fruit contains many health benefits so it would be very good if used as food. One of the efforts to use noni can be done by creating a product in the form of organic jam. This study aims to determine the quality of noni fruit jam using the same level of maturity in terms of taste, color, texture and aroma. The data collection method used in this research is the organoleptic test method, documentation and questionnaires. This quantitative and qualitative research was also obtained from the power of the assessment test instrument. The respondents in this study amounted to 70 people consisting of the community around the research site (North Bogor) including IPB students, school students, motorcycle drivers and housewives. The results of the research based on organoleptic tests showed that organic noni jam products were acceptable in the market with a taste score of 275 (tasty), texture 240 (chewy), aroma 195 (quite delicious), and color 188 (quite attractive)
Keywords: business product, noni fruit, organic jam
Mechanisms Connecting Police Brutality, Intersectionality, and Women’s Health Over the Life Course
Authors: Alang Sirry , Haile Rahwa , Hardeman Rachel , Judson Jé 
Published: January 2023

Police brutality harms women. Structural racism and structural sexism expose women of color to police brutality through 4 interrelated mechanisms: (1) desecration of Black womanhood, (2) criminalization of communities of color, (3) hypersexualization of Black and Brown women, and (4) vicarious marginalization. We analyze intersectionality as a framework for understanding racial and gender determinants of police brutality, arguing that public health research and policy must consider how complex intersections of these determinants and their contextual specificities shape the impact of police brutality on the health of racially minoritized women. We recommend that public health scholars (1) measure and analyze multiple sources of vulnerability to police brutality, (2) consider policies and interventions within the contexts of intersecting statuses, (3) center life course experiences of marginalized women, and (4) assess and make Whiteness visible. People who hold racial and gender power—who benefit from racist and sexist systems—must relinquish power and reject these benefits. Power and the benefits of power are what keep oppressive systems such as racism, sexism, and police brutality in place. (Am J Public Health. 2023;113(S1):S29–S36. https://doi.org/10.2105/AJPH.2022.307064 )
Strategies for Naming and Addressing Structural Racism in Immigrant Mental Health
Authors: Cerda Ivo H. , Macaranas Anjeli R. , Liu Cindy H. , Chen Justin A. 
Published: January 2023

Immigrants account for 13.7% of the US population, and the great majority of these individuals originate from Latin America or Asia. Immigrant communities experience striking inequities in mental health care, particularly lower rates of mental health service use despite significant stressors. Structural barriers are a significant deterrent to obtaining needed care and are often rooted in racist policies and assumptions. Here we review and summarize key pathways by which underlying structural racism contributes to disparities in immigrant mental health, including anti-immigration policies, labor and financial exploitation, and culturally insensitive mental health services. Significant accumulated research evidence regarding these barriers has failed to translate into structural reform and financial investment required to address them, resulting in pronounced costs to both immigrant populations and society at large. We propose specific strategies for addressing relevant structural inequities, including reforming economic and financial policies, community education initiatives, and task-sharing and strengths-based interventions developed in partnership with immigrant communities to promote access to mental health care for populations in dire need of culturally appropriate services. (Am J Public Health. 2023;113(S1): S72–S79. https://doi.org/10.2105/AJPH.2022.307165 )
Total Polyphenol Content of Bromelia Leaves (Neoregelia marmorata) Etanol Extract
Authors: Safitri Malikah , Susanti Erna 
Published: January 2023

This study aims to determine total polyphenol content of Bromelia (Neoregelia marmorata) leaves extract with ethanol and water solvent ratio. There are three kinds of comparisons, ethanol 96%, ethanol 50 % and aquadest. The third variation of the extract is then determined the total polyphenol content. Determination of total polyphenol content was performed using visible light spectrophotometry at wavelength 758 nm with Folin-ciocalteu reagent and standard used was gallic acid. The highest average polyphenol content was obtained ethanol extract 96% then ethanol 50%, aquadest that is 0,4710 mgGAE / g; 0.3677 mgGAE / g; 0.1847 mgGAE / g. The more part of ethanol 96%, the total polyphenol content is higher. Furthermore, one way anova test is used to know the difference in the three extracts and followed by Post Hoc test. The results of the analysis showed significant differences between the three variants extract with probability value (p≤0,05).
7,8-Dihydroxyflavone induces mitochondrial apoptosis and down-regulates the expression of ganglioside GD3 in malignant melanoma cells
Authors: Ju Won Seok , Seo Sang Young , Mun Seong-eun , Kim Kyongtae , Yu Jin Ok , Ryu Jae-Sung , Kim Ji-Su , Choo Young-Kug 
Published: January 2023

AbstractMalignant melanoma is one of the most progressive skin cancers, with a poor prognosis, various side effects, and high resistance to conventional treatment. Recently, 7,8-dihydroxyflavone (7,8-DHF), a polyphenolic flavonoid derived from certain plants, has been studied for its anti-carcinogenic, anti-inflammatory, antioxidant, and pharmacological effects in several types of cancer. Ganglioside, a modulator of diverse cell signals on the microdomain of the surface of the cell membrane, is closely involved in various cancers such as neuroblastoma. However, the correlation between ganglioside expression and the anti-cancer effects of 7,8-DHF in malignant melanoma remains unclear. In this study, 7,8-DHF showed potential as an anti-cancer agent through specific anti-proliferation, anti-oxidant, anti-migration, pro-apoptotic, and G2/M phase cell cycle arrest effects on SK-MEL-2 and G-361 melanoma cells. In contrast, 7,8-DHF did not induce cytotoxicity in non-tumoral epidermal HaCaT cells. Additionally, we confirmed for the first time that 7,8-DHF significantly reduces the expression levels of ganglioside GD3, which is closely involved in carcinogenesis, in both melanoma cancer cell lines using high-performance thin-layer chromatography analysis. Taken together, our findings suggest that 7,8-DHF might be a potent anticancer drug candidate for the treatment of malignant melanoma.
Cost-effectiveness analysis of pembrolizumab versus chemotherapy as the first-line treatment in patients with mismatch-repair-deficient (dMMR) or microsatellite- instability-high (MSI-H) advanced or metastatic colorectal cancer from a perspective of health care system in China
Authors: ZHU CHEN , Han Gang , Wu Bin 
Published: January 2023

Abstract
Background
Pembrolizumab is superior to chemotherapy as a first-line treatment for patients with mismatch-repair-deficient (dMMR) or microsatellite-instability-high (MSI-H) advanced or metastatic colorectal cancer (CRC), with a significantly long-term survival benefit trend by KYENOTE-177. The current study aimed to determine whether pembrolizumab is a cost-effective treatment for patients with dMMR/MSI-H advanced or metastatic CRC in China.
Methods
A partitioned survival model (PSM) was developed to simulate patients with dMMR/MSI-H advanced or metastatic CRC based on health states of progression-free survival (PFS), progressive disease (PD) and death. The model was designed using a lifetime horizon, a 6-week cycle, and a 5% discount rate. The characteristics of patients in the model were similar to patients in a phase 3, open-label randomized clinical trial (KEYNOTE-177) who had metastatic MSI-H–dMMR CRC and had not previously received treatment. The health outcomes and utilities were from the KETNOTE-177 trial and published data, respectively. Costs were calculated based on local charges (2021) and published literature. It is deemed cost-effective in China if the incremental cost-effectiveness ratio (ICER) value is less than $33,600 per quality adjusted life-year (QALY). The robustness of the results was discussed in one-way deterministic and probabilistic sensitivity analyses.
Results
Baseline analysis disclosed that pembrolizumab provided an additional 2.58 QALYs (3.00 life-years) at an incremental cost of $78,286.04, resulting in an ICER of $30,330.15 per QALY, which was below the willingness-to-pay threshold of $33,600 per QALY. When patient assistance program (PAP) was considered, the ICER became $1,730.67 per QALY, manifesting absolute cost-effectiveness. The results of sensitivity analyses demonstrated that in most cases pembrolizumab was cost-effective.
Conclusions
Pembrolizumab is a cost-effective first-line treatment for dMMR/MSI-H advanced or metastatic CRC patients in China, especially considering PAP.
Prevalence of anxiety, depression and post-traumatic stress disorder symptoms and resilience in adolescents during the COVID-19 pandemic in a post-armed conflict area in Colombia
Authors: Gómez-Restrepo Carlos , Sarmiento-Suárez María José , Alba-Saavedra Magda , Calvo-Valderrama María Gabriela , Rincón-Rodríguez Carlos Javier , González-Ballesteros Lina María , Bird Victoria , Priebe Stefan , Loggerenberg Francois van 
Published: January 2023

Abstract

The impact of COVID-19 pandemic on mental health of adolescents are emerging and require particular attention in settings where challenges like armed conflict, poverty and internal displacement have previously affected their mental wellbeing. This study aimed to determine the prevalence of mental health problems and symptoms of anxiety and depression, probable post-traumatic stress disorder, and resilience capacity in adolescents in a post-armed conflict area in Colombia during the COVID-19 pandemic. A cross-sectional study was conducted with 657 school attending adolescents aged 12 to 18 years old. Mental health information was obtained through screening scales for anxiety (GAD-7), depression (PHQ-8), probable post-traumatic stress disorder (PCL-5) and resilience capacity (CD-RISC-25). The prevalence observed for moderate to severe depression symptoms was 30.0% (CI95%=26.5–33.7) and for moderate to severe anxiety symptoms was 18.9% (CI95%=16.0-22.1). A prevalence of probable post-traumatic stress disorder (PTSD) of 22.3% (CI95%=18.1–27.2) was found. The CD-RISC-25 results for resilience had a median score of 54 [IQR:30]. Our results are in line with emerging evidence that suggests multiple domains of adolescents’ mental wellbeing were negatively impacted by the pandemic, and agree with other studies of regions affected by the armed conflict that show an increase in the prevalence of mental health disorders in young populations. In contrast, our data show lower resilience than other studies of adolescents. These findings call for multidisciplinary actions necessary to respond effectively to the impact of the pandemic on the mental health of adolescents, as well as to guarantee a successful educational recovery, being schools key places in which prompt intervention might reduce the burden of mental distress in adolescents.
Eucalyptus globulus vessels enzymatic passivation: effect of pore structure on bulk and surface chemistry
Authors: Vaz Álvaro , Coelho João , Costa Vera , Maloney Thaddeus , Josphat Phiri , Pinto Paula , Sousa António Mendes , Simões Rogério 
Published: January 2023

Abstract

Hardwood vessel elements generate problems in industrial uncoated wood-free printing paper operation, causing vessel picking and ink refusal. These problems are mitigated using mechanical refining at the cost of paper quality. Vessel enzymatic passivation, altering its adhesion to the fiber network and reducing its hydrophobicity is a way of improving paper quality. The object of this paper is to study how the enzymatic treatment by xylanase and by an enzymatic cocktail containing cellulases and laccases affect elemental chlorine free bleachedEucalyptus globulusvessel and fiber porosities, bulk, and surface chemical compositions. Thermoporosimetry revealed the vessel structure to be more porous, surface analysis showed its lower O/C ratio and bulk chemistry analysis its higher hemicellulose content. Enzymes had different effects on porosity, bulk and surface composition of fibers and vessels, affecting vessel adhesion and hydrophobicity. It is proposed that differences in vessel and fiber porosity structures affect the enzymatic attacks, eventually causing vessel passivation.