bluuebunny/crossref_metadata_2025_split huggingface dataset:
Return to work improves quality of life and reduces psychosocial distress after radical cystectomy: data from a contemporary series of 230 German patients
Authors: Bahlburg Henning , Reike Moritz , Tully Karl , Bach Peter , Butea-Bocu Marius Cristian , Roghmann Florian , Noldus Joachim , Müller Guido 
Published: May 2023

Abstract
Purpose
This study aims to evaluate health-related quality of life (HRQoL), psychosocial distress, and return to work (RTW) 2 years after radical cystectomy (RC) and inpatient rehabilitation (IR).

Material and methods
The study relied on prospectively collected data for 842 patients, who underwent 3 weeks of IR after RC and creation of an ileal conduit (IC) or ileal neobladder (INB). Validated questionnaires surveyed patients on HRQoL and psychosocial distress (EORTC QLQ-C30, QSC-R10). Furthermore, employment status was evaluated. Regression was performed to identify predictors for HRQol, psychosocial distress, and RTW.

Results
Two-hundred and thirty patients were employed pre-surgery (77.8% INB, 22.2% IC). Patients with an IC suffered significantly more often from locally advanced disease (≥ pT3: 43.1% vs 22.9%; p = 0.004). Two years after surgery, 16.1% of patients had died (median days of survival 302 (IQR 204–482). Global HRQoL improved steadily, while high psychosocial distress was present in 46.5% of patients 2 years after surgery. Employment was reported by 68.2% of patients, of which 90.3% worked full-time. Retirement was reported by 18.5%. Multivariate logistic regression analysis identified age ≤ 59 years as the only positive predictor for RTW 2 years after surgery (OR 7.730; 95% CI 3.369–17.736; p < 0.001). Gender, surgical technique, tumor stage, and socioeconomic status did not influence RTW in this model. In multivariate linear regression analysis, RTW was identified as an independent predictor of better global HRQoL (p = 0.018) and lower psychosocial distress (p < 0.001), whereas younger patient age was identified as an independent predictor for higher psychosocial distress (p = 0.002).

Conclusion
Global HRQoL and RTW are high among patients two years after RC. However, role and emotional, cognitive, and social functioning were significantly impaired, while high psychosocial distress persists in a material number of patients.

Implications for Cancer Survivors
Our study highlights how a successful RTW decreases psychosocial distress and increases QoL in patients after RC for urothelial cancer. Nonetheless, additional efforts by employers and healthcare providers are needed in aftercare after creation of an INB or IC.
Data-driven approaches in predicting scour depths at a vertical seawall on a permeable shingle foreshore
Authors: Salauddin M. , Shaffrey D. , Habib M. A. 
Published: May 2023

AbstractDespite recent research efforts in advancing machine learning (ML) tools to predict nearshore characteristics at sea defences, less attention has been paid to ML algorithms in predicting scouring characteristics at vertical seawalls. In this study, four ML approaches were investigated, including gradient boosting decision trees (GBDT), random forest (RF), support vector regression (SVR), and ridge regression (RR). These approaches were utilised to predict scour depths at the toe of an impermeable vertical seawall in front of a permeable shingle slope. The developed ML algorithms were trained and tested (70% for training and 30% for testing) using the scouring datasets collected from laboratory tests performed on seawalls in a 2D wave flume at the University of Warwick. A novel hyperparameter tuning analysis was performed for each ML model to tailor the underlying dataset features while mitigating associated data overfitting risks. Additionally, the model training process demonstrated permutation feature importance analysis to reduce overfitting and data redundancy. The model predictions were compared with the observed values using the coefficient of determination (R2) score, root mean square error (RMSE), and Pearson correlation R-value. Consequently, the RF and GBDT methods accurately predicted scour depths at the toe of vertical seawalls with shingle foreshores. This study produced data, information, and a model that could directly or indirectly benefit coastal managers, engineers, and local policymakers. These benefits included forecasting scour depths and assessing the impact on the structural integrity of the sea defences in response to the threat imposed by extreme events, which are essential for the sustainable management of coastal protections and properties behind such structures in coastal areas.
Early Stage and Locally Advanced Nasopharyngeal Carcinoma Treatment from Present to Future: Where Are We and Where Are We Going?
Authors: Juarez-Vignon Whaley Juan Jose , Afkhami Michelle , Sampath Sagus , Amini Arya , Bell Diana , Villaflor Victoria M. 
Published: May 2023

Opinion statementNasopharyngeal carcinoma (NPC) is a rare malignancy, endemic in China, that is commonly diagnosed in locally advanced scenarios. Its pathogenesis is strongly associated with Epstein-Barr virus (EBV), an infection for which measuring EBV plasma DNA levels has helped as a prognostic factor guiding treatment options, including a stronger treatment in those with high titers. Additionally, tobacco and alcohol are often implicated in EBV-negative patients. The local disease is treated with radiotherapy alone, preferentially intensity modulated radiotherapy. For locally advanced disease, the backbone treatment is concurrent chemoradiotherapy with the ongoing research dilemma being adding adjuvant chemotherapy or induction chemotherapy. The ongoing research is focused not only on identifying patients that will benefit from adjuvant or induction chemotherapy, but also on identifying the best chemotherapeutic regimen, regimen alternatives to diminish toxicity, the role that immune checkpoint inhibitors play, and the use of molecularly guided treatment targeting patients with NPC whether driven by EBV or tobacco and alcohol. Knowing the precise oncogenesis of NPC not only offers a better understanding of the role that EBV plays in this tumor but also helps create targeted therapies that could potentially block important pathways such as the NF-κB pathway. Much is yet to be done, but the prognosis and management of NPC patients have changed drastically, offering precise treatment methods and excellent control of the disease, even in locally advanced scenarios.
Energy poverty and the convergence hypothesis across EU member states
Authors: Anastasiou Athanasios , Zaroutieri Eftychia 
Published: May 2023

AbstractEnergy poverty is an emerging issue towards global affairs. Currently, the development of energy-related policies is becoming essential, with regard to new societies, social inclusion and social rights. In this paper, we examine the dynamic patterns of energy poverty among 27 EU member states between 2005 and 2020. We use the log-t regression test to investigate the convergence hypothesis, and the P&S data-driven algorithm to detect potential convergence clubs. The empirical results of energy poverty indicators are mixed, and the convergence hypothesis of the states is rejected. Instead, convergence clubs are exhibited, implying that groups of countries converge to different steady states in the long run. In view of the convergence clubs, we suggest that the affordability of heating services is potentially explained by structural conditions of housing, climate conditions and energy costs. Besides, the adverse financial and social conditions for the European households have significantly triggered the arrears on utility bills. Moreover, a significant proportion of households do not have basic sanitation services.
Quasicrystals: fragments of history and future outlooks
Authors: Bindi Luca , Parisi Giorgio 
Published: May 2023

AbstractWith this article, we briefly retrace the history of quasicrystals and introduce the Topical collection on “Quasicrystals: State of the art and outlooks”, consisting of a number of review articles published in the frame of a conference held at the Accademia dei Lincei in November 2022.
ESMO update: upper gastrointestinal cancer
Authors: Bergen Elisabeth S. , Ihan-Mutlu Aysegül 
Published: May 2023

SummaryAt the European Society for Medical Oncology (ESMO) 2022 annual meeting, several pertinent studies in the field of upper gastrointestinal cancer were presented. The most practice-changing study appeared to be the Destiny-Gastric02 study evaluating trastuzumab–deruxtecan as a second-line treatment option in patients with Her2-positive gastric and gastroesophageal junction cancer. The median overall survival was 12.1 months with a confirmed overall response rate of 41.8%. 55.7% of patients experienced grade ≥ 3 events with nausea, vomiting, and fatigue being the most frequently observed. This study led to the approval of trastuzumab–deruxtecan as second-line therapy in patients with Her2-positive gastric and gastroesophageal junction tumors who have experienced disease progression after first-line trastuzumab-containing therapy.
Permeability of Dimethyl Phthalate Through Human Skin Models – Health Risk Assessment
Authors: Olkowska Ewa 
Published: May 2023

AbstractDimethyl phthalate (DMP) is used widely in cosmetics and personal care products as a solvent, skin penetrant, moisturizer and softener as well as an anti-cracking agent. Dermal absorption is one of the major exposure routes for lower molecular weight phthalates such as DMP and assessing their dermal permeability is important for evaluating the impact and toxicity of such compounds in humans. The aim of this study was to evaluate DMP permeability through different human skin models (Strat-M® synthetic membrane, in vitro reconstructed human epidermis and human dermatomed skin) using solutions containing various types of surfactants, as a simulation of the types of mixtures occurring in cosmetics and personal care products, in order to ascertain the impact that surfactants can have on skin permeability. The results have shown that human skin is the least permeable of the used skin models, and that surfactants (in particular cationic and non-ionic) lead to a significant increase of DMP permeability through all skin models. The performed risk assessment however shows that, for all tested models, the margin of safety was not exceeded.
A prospective study of the association of weekend catch-up sleep and sleep duration with mortality in middle-aged adults
Authors: Yoshiike Takuya , Kawamura Aoi , Utsumi Tomohiro , Matsui Kentaro , Kuriyama Kenichi 
Published: May 2023

AbstractHealth effects of weekend catch-up sleep (CUS) could differ depending on both the ability to obtain sufficient sleep during weekdays and amount of weekend CUS required to compensate for sleep lost during the week. ﻿Using data from 3128 middle-aged (40–64 years) participants of the Sleep Heart Health Study, we examined the longitudinal association of these two aspects of sleep with all-cause mortality. CUS was calculated as the difference in self-reported habitual sleep duration between weekends and weekdays, and classified into no, short (1 h), and long (2 h or more) CUS. Polysomnography-measured total sleep time, representing the ability to obtain sufficient sleep, was classified into short (< 360 min) or normal (≥ 360 min) sleep durations. We estimated multivariable-adjusted mortality hazard ratios (HRs) and 95% confidence intervals (CIs) for six groups divided by the extent of CUS and sleep duration. Participants were followed up for a median (interquartile range) of 12.3 (11.3–13.5) years. Short weekend CUS with normal sleep duration was associated with lower mortality compared to no CUS with normal sleep duration (﻿HR, 0.48; 95% CI 0.27–0.83). When stricter cutoffs were applied for sleep durations, while the protective effect of short CUS with normal sleep duration (≥ 390 min) was strengthened (HR, 0.36; 95% CI 0.17–0.78), the harmful effect of short CUS with short sleep duration (< 330 min) emerged (HR, 1.84; 95% CI 1.08–3.14). Results highlight the importance of balancing sleep ability and CUS. Sufficient sleep may reduce weekday sleep debt and only a short CUS would be required on weekends, improving mortality in middle-aged adults.
Bargaining Power in a Globalized World: The Effect of Global Value Chains in Trade Negotiations
Authors: Stiller Yannick 
Published: May 2023

AbstractWhat determines the bargaining power of states in international trade negotiations? The literature focuses predominantly on economic strength as the determinant of bargaining power. However, this explanation neglects the reality of modern trade, which is characterized by the globalization of production and high levels of economic interdependence. I argue that this interdependence undermines the effect of economic strength on the bargaining power of states. Specifically, I hypothesize that the effect of economic strength declines when a country's companies rely on inputs for their production from a negotiation partner because they are integrated into global value chains. The more a country's firms are dependent on a partner country, the less that country is able to coerce concessions from the partner country by bringing to bear its economic strength. To test this hypothesis, I use a dataset covering concessions on liberalization of the services sector made by 54 countries in 61 preferential trade agreements. By calculating the relative concessions of each partner, I construct a quantitative indicator of the outcome of trade negotiations. This indicator should reflect the underlying bargaining power of each negotiating party. The results of a regression analysis of these negotiation outcomes mostly support my hypotheses.
Examining the value of satellite data in halting transmission of polio in Nigeria: A socioeconomic analysis
Authors: Borowitz Mariel , Zhou Janet , Azelton Krystal , Nassar Isabelle-Yara 
Published: May 2023

Abstract
In 2014, Nigeria halted transmission of wild poliovirus for the first time in its history. A critical enabling component in this historic achievement was the use of satellite data to produce more accurate maps and population estimates used in planning and implementing vaccination campaigns. This article employs a value-of-information approach to estimate the net socioeconomic benefits associated with this use of satellite data. We calculate the increase in the likelihood of halting transmission of polio associated with the use of satellite-based information compared to traditional data sources, and we consider the benefits associated with savings to the healthcare system as well as health benefits. Using a conservative approach focused on just 1 year of benefits, we estimate net socioeconomic benefits of between $46.0 million and $153.9 million. In addition to these quantified benefits, we also recognize qualitative benefits associated with improving human health, reaching marginalized communities, and building capacity among local populations. We also explore the substantial benefits associated with follow-on projects that have made use of the satellite-based data products and methodologies originally developed for the Nigeria polio eradication effort.
On Inferring Explanations and Inference to the Best Explanation
Authors: Davey Kevin 
Published: May 2023

Abstract
Although the inferring of explanations plays an important role in both our everyday lives and in the workings of science, I argue that inference to the best explanation as it is commonly conceived is often not the best way to capture this sort of reasoning. I suggest that a different form of reasoning – so-called immediate explanatory inference – is instead often much better suited to this task. This is a form of inference in which we are justified in believing explanations for the evidence before us purely in virtue of this evidence, and not in virtue of the evidence plus some general principle or rule of non-deductive reasoning. I defend the idea of such a notion of inference, and argue that it plays a central role in both ordinary life and science.
Paleobiological implications of the bone histology of the extinct Australian marsupial Nimbadon lavarackorum
Authors: Chinsamy Anusuya , Black Karen H. , Hand Suzanne J. , Archer Michael 
Published: May 2023

AbstractDespite the recognition that bone histology provides much information about the life history and biology of extinct animals, osteohistology of extinct marsupials is sorely lacking. We studied the bone histology of the ca. 15-million-year-old Nimbadon lavarackorum from Australia to obtain insight into its biology. The histology of thin sections of five femora and five tibiae of juveniles, subadult, and adult Nimbadon lavarackorum was studied. Growth marks in the bones suggest that N. lavarackorum took at least 7–8 years (and likely longer) to reach skeletal maturity. The predominant bone tissue during early ontogeny is parallel-fibered bone, whereas an even slower rate of bone formation is indicated by the presence of lamellar bone tissue in the periosteal parts of the compacta in older individuals. Deposition of bone was interrupted periodically by lines of arrested growth or annuli. This cyclical growth strategy indicates that growth in N. lavarackorum was affected by the prevailing environmental conditions and available resources, as well as seasonal physiological factors such as decreasing body temperatures and metabolic rates.
Epidemiological characteristics of paediatric Omicron infection during the outbreak of SARS-CoV-2 infection during March–May in 2022 in Shanghai, China
Authors: Chang Hailing , Zhang Xuanzhao , Su Hualin , Cai Jiehao , Liu Xiaohua , Li Jingjing , Wang Yating , Zhang Zhaowen , Zhu Minghui , Zhao Lifang , Zhang Sijia , Mei Kewen , Zhang Liping , Wang Xiaoguang , Yan Hongjin , Luo Lingfei , Xu Zhiyin , Zeng Mei 
Published: May 2023

Abstract
This study aims to understand the epidemiological characteristics of SARS-CoV-2 infection in the paediatric population during the outbreak of the Omicron variant in Shanghai. We retrospectively analysed the population-based epidemiological characteristics and clinical outcome of SARS-CoV-2 Omicron variant infection in children in Minhang District, Shanghai, based on the citywide surveillance system during the outbreak period in 2022 (March to May). During this time, a total of 63,969 cases of SARS-CoV-2 infection were notified in Minhang District, out of which 4,652 (7.3%) were children and adolescents <18 years. The incidence rate of SARS-CoV-2 infections in children was 153 per 10,000. Of all paediatric cases, 50% reported to be clinically symptomatic within 1–3 days after PCR confirmation by parents or themselves, with 36.3% and 18.9% of paediatric cases reporting fever and cough. Also, 58.4% of paediatric cases had received at least one dose of the COVID-19 vaccine and 52.1% had received two doses of the COVID-19 vaccination. Our findings are informative for the implementation of appropriate measures to protect children from the threat of SARS-CoV-2 infection.
Early childhood impulsivity and parenting predict children’s development of externalizing psychopathology
Authors: Stewart Emma K. , Kotelnikova Yuliya , Olino Thomas M. , Hayden Elizabeth P. 
Published: May 2023

AbstractParenting and child impulsivity are consistent predictors of children’s externalizing symptoms; however, the role of the range of parenting (i.e., variation in parenting across contexts), and its interactions with child impulsivity, are poorly understood. We examined whether characteristic parenting practices and parenting range predicted the course of externalizing symptoms in 409 children (Mage = 3.43 years at baseline, 208 girls) across ages 3, 5, 8, and 11. We assessed parent positive affectivity (PPA), hostility, and parenting structure at child age 3 using three behavioral tasks that varied in context, examining range by modeling a latent difference score for each parenting dimension. Greater PPA range, mean structure, and parenting structure range all predicted fewer symptoms at age 3 for children with higher impulsivity. Lower mean hostility predicted fewer symptoms at age 3 for children with lower impulsivity. Greater PPA, and smaller PPA range, predicted a decrease in symptoms for children higher in impulsivity. Lower hostility range predicted a decrease in symptoms for children with lower impulsivity but predicted maintaining symptoms for children with higher impulsivity. Results demonstrate the differential roles average parenting practices and parenting range play in the development of child externalizing psychopathology, especially in the context of child impulsivity.
The Bronze Serpent: Abuse, Trauma and the Lifted Healer in the Wilderness
Authors: King Fergus J. , Poobalan Isaac 
Published: May 2023

AbstractMany Christian groups and churches have been forced to recognize that they have been complicit in behaviour which has betrayed the gospel. How then is the church to address the historical reality of being an abusive healer? The image of the bronze serpent (Num. 21.4-9; 2 Kgs 18.4; Jn 3.14) offers an ambiguous image which may reveal the reality of the church as both a source of abuse and trauma as well as an instrument of healing within a pattern of restorative justice.
Circuits for 5G RF front-end modules
Authors: Balteanu Florinel 
Published: May 2023

AbstractWorldwide adoption of fourth-generation wireless (4G) long-term evolution (LTE) smartphones and the actual transition to fifth-generation wireless(5G) is the main driving engine for semiconductor industry. 5G is expected to reach high data rate speeds (1 Gbps) and low latency (<1 ms). 5G requires more RF bandwidth and therefore an increase in the number of components such as RF switches, acoustic filters, and power amplifiers integrated in few RF front-end modules. Also, there is an increase in the number of RF radio transmitters and receivers operating at the same time. This paper presents new architecture elements for 5G RF front-end modules. Circuit details and measurements are presented to reduce the RF noise, improve the efficiency, and help the coexistence of multiple radio transmitters. These circuits will help extend the 5G applications with radar-like sensing applications, remote medicine, and autonomous driving.
Study on Differential Phase Delay of Same‐Beam VLBI in Rendezvous and Docking of Chang'E‐5
Authors: Wang Zhichao , Li Peijia , Zheng Xin , Liu Qinghui , Ma Maoli , He Qingbao , Rui Ping , Xu Zhijun , Zhang Juan , Tong Fengxian 
Published: May 2023

AbstractThe Chang'E‐5 (CE5) ascender achieved lunar orbit autonomous rendezvous and docking with orbiter‐returner successfully on 5 December 2020. Same‐beam Very Long Baseline Interferometry (VLBI) (SBI) observations were performed for the first time for autonomous rendezvous and docking in lunar orbit. In this paper, by studying the CE5 rendezvous and docking data observed by the Chinese VLBI network and analyzing the residual differential phase delay of the autonomous control phase, we successfully captured the maneuver of the 5 km holding of the orbiter‐returner. The differential phase delay (DPD) data of the far‐range guidance phase were used to perform orbit determination of the ascender and orbiter‐returner successfully. The results of orbit determination show that the DPD data can improve the relative position accuracy between the ascender and the orbiter‐returner, and the residual root mean square of the DPD data is 5 ps. Furthermore, when one of the probes has only DPD data, its orbit can also be determined.