bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Name-glorifying projects of Alexei Losev and Pavel Florensky: A question of their historical interrelation
Authors: Biriukov Dmitry 
Published: May 2023

Abstract
This article deals with the question of the interrelation between two papers, both called, in short, “Onomatodoxy”, dedicated to the doctrine of Name-glorification (Imiaslavie, Onomatodoxy), both of which were created in line with the Neo-Patristic movement in the Russian philosophy of the Silver Age. One of these papers is by Alexei Losev and the other by Pavel Florensky. In my opinion, there are sufficient grounds to state that Losev’s “Onomatodoxy” was written either after Florensky created his own “Onomatodoxy”, i.e., after November 1922, or, at the earliest, after Florensky started to give clandestine lectures about Onomatodoxy in Moscow (where Losev lived), i.e., not earlier than spring 1921. Therefore, Losev’s article “Onomatodoxy” could have been intended for the religious-philosophical collection of articles planned for publishing by Yaschenko in 1922 in Berlin.
A transgenic mouse line for assaying tissue-specific changes in endoplasmic reticulum proteostasis
Authors: Svarcbahs Reinis , Blossom Sarah M. , Baffoe-Bonnie Helena S. , Trychta Kathleen A. , Greer Lacey K. , Pickel James , Henderson Mark J. , Harvey Brandon K. 
Published: May 2023

AbstractMaintenance of calcium homeostasis is important for proper endoplasmic reticulum (ER) function. When cellular stress conditions deplete the high concentration of calcium in the ER, ER-resident proteins are secreted into the extracellular space in a process called exodosis. Monitoring exodosis provides insight into changes in ER homeostasis and proteostasis resulting from cellular stress associated with ER calcium dysregulation. To monitor cell-type specific exodosis in the intact animal, we created a transgenic mouse line with a Gaussia luciferase (GLuc)—based, secreted ER calcium-modulated protein, SERCaMP, preceded by a LoxP-STOP-LoxP (LSL) sequence. The Cre-dependent LSL-SERCaMP mice were crossed with albumin (Alb)-Cre and dopamine transporter (DAT)-Cre mouse lines. GLuc-SERCaMP expression was characterized in mouse organs and extracellular fluids, and the secretion of GLuc-SERCaMP in response to cellular stress was monitored following pharmacological depletion of ER calcium. In LSL-SERCaMP × Alb-Cre mice, robust GLuc activity was observed only in the liver and blood, whereas in LSL-SERCaMP × DAT-Cre mice, GLuc activity was seen in midbrain dopaminergic neurons and tissue samples innervated by dopaminergic projections. After calcium depletion, we saw increased GLuc signal in the plasma and cerebrospinal fluid collected from the Alb-Cre and DAT-Cre crosses, respectively. This mouse model can be used to investigate the secretion of ER-resident proteins from specific cell and tissue types during disease pathogenesis and may aid in the identification of therapeutics and biomarkers of disease.
Life cycle assessment of bio-based fertilizers production systems: where are we and where should we be heading?
Authors: Egas D. , Azarkamand S. , Casals C. , Ponsá S. , Llenas L. , Colón J. 
Published: May 2023

Abstract
Purpose
Despite the industrial and scientific acceptance of life cycle assessment (LCA) to determine the environmental performance of products, none of the existing information on LCA provides explicit and clear recommendations on how to apply it when evaluating bio-based fertilizer (BBF) production systems. This situation affects the reliability of the results and causes confusion among practitioners, technology developers, and other stakeholders. Here, we first present the practitioners’ current LCA methodological choices and then discuss the extent to which LCA standards and guidelines are correctly applied. This review intends to identify LCA methodological application hotspots towards the definition of consensual LCA methodological choices for BBFs.

Method
LCA studies for BBF production systems were reviewed together with currently available LCA standards and guidelines to define which LCA methodological options are adopted by LCA practitioners in the first place, and then to determine whether these options are within the framework of existing LCA standards and guidelines. The results obtained are presented and discussed to finally debate and evidence the need for consensual LCA methodological choices for BBFs.

Results and discussion
A total of 48 documents were reviewed between LCA standards and guidelines (8) and studies (40). Most of the reviewed studies state that BBFs are the main product of the system (30), while the remaining ones state them as secondary products. Although the standards and guidelines statements are interrelated, it is challenging to follow their recommendations when applied in studies evaluating BBF production. For instance, LCA studies do not clearly define the studies’ promotor, motivation, and specific research question which leads to a lack of justification regarding the taken choice between attributional or consequential LCA. Therefore, the next LCA methodological choices such as functional unit, allocation criteria, biogenic carbon management, and end-of-life status of feedstock, are not justified.

Conclusion
It has been evidenced that the lack of consensual LCA methodological choices is affecting the proper use of the LCA by practitioners that aim to assess BBFs production systems. Thus, it shall be imperative for researchers and technology developers to work on the definition of common LCA methodological choices. This study has concluded that more guidance on the process of defining the study’s promotor, motivation, and specific research question is highly needed by practitioners since this would lead to the definition of common goals and scopes, first, and then, set the path to define standard LCA methodological choices.
Crohn’s disease and breast cancer: a literature review of the mechanisms and treatment
Authors: Zhou Sisi , Yu Jing 
Published: May 2023

AbstractThis is a literature review describes Crohn’s disease (CD) concomitant with breast cancer and summarizes possible common pathogenic mechanisms shared by the two diseases involving the IL-17 and NF-κB signaling pathways. Inflammatory cytokines including TNF-α and Th17 cells in CD patients can induce activation of the ERK1/2, NF-κB and Bcl-2 pathways. Hub genes are involved in the generation of cancer stem cells (CSCs) and are related to inflammatory mediators, including CXCL8, IL1-β and PTGS2, which promote inflammation and breast cancer growth, metastasis, and development. CD activity is highly associated with altered intestinal microbiota processes, including secretion of complex glucose polysaccharides by Ruminococcus gnavus colonies; furthermore, γ-proteobacteria and Clostridium are associated with CD recurrence and active CD, while Ruminococcaceae, Faecococcus and Vibrio desulfuris are associated with CD remission. Intestinal microbiota disorder promotes breast cancer occurrence and development. Bacteroides fragilis can produce toxins that induce breast epithelial hyperplasia and breast cancer growth and metastasis. Gut microbiota regulation can also improve chemotherapy and immunotherapy efficacy in breast cancer treatment. Intestinal inflammation can affects the brain through the brain–gut axis, which activates the hypothalamic‒pituitary‒adrenal (HPA) axis to induce anxiety and depression in patients; these effects can inhibit the antitumor immune responses of the immune system and promote breast cancer occurrence in patients with CD. There are few studies on the treatment of patients with CD concomitant with breast cancer, but published studies show three main strategies: new biological agents combined with breast cancer treatment methods, intestinal fecal bacteria transplantation, and dietary treatment.
Microstructure and Mechanical Properties of an Advanced Ag-Microalloyed Aluminum Crossover Alloy Tailored for Wire-Arc Directed Energy Deposition
Authors: Klein Thomas , Arnoldt Aurel , Gomes Manuel , Barriobero-Vila Pere 
Published: May 2023

AbstractThe implementation of wire-arc directed energy deposition requires the development of novel, process-adapted, high-performance aluminum alloys. Conventional high-strength alloys are, however, difficult to process as they are prone to hot-cracking. Crossover alloys based on Al-Mg-Zn combine good processability with good mechanical properties following artificial aging. Here, we present an effort to further improve the mechanical properties of Al-Mg-Zn crossover alloys using Ag microalloying. No cracks and few porosities were observed in the samples. The microstructure is dominated by fine and globular grains with a grain size ≈ 26.6 µm. The grain structure is essentially free of texture and contains fine microsegregation zones with ≈ 3–5 µm thickness of segregation seams. Upon heat treatment these microsegregation zones are dissolved and T-phase precipitates are formed as clarified by diffraction experiments. This precipitation reaction results in a microhardness of ≈ 155 HV0.1, a yield strength of 391.3 MPa and 418.6 MPa, an ultimate tensile strength of 452.7 MPa and 529.4 MPa and a fracture strain of 3.4% and 4.4% in transversal and in longitudinal directions, respectively. The gained results suggest that highly loaded structures can be manufactured by wire-arc directed energy deposition using the newly developed aluminum crossover alloy.
Apperceptive and Associative Forms of Phonagnosia
Authors: Gainotti Guido , Quaranta Davide , Luzzi Simona 
Published: May 2023

Abstract
Purpose of Review
Pronagnosia is a rare acquired or developmental pathological condition that consists of a selective difficulty to recognize familiar people by their voices. It can be distinguished into two different categories: apperceptive phonagnosia, which denotes a purely perceptual form of voice recognition disorder; and associative phonagnosia, in which patients have no perceptual defects, but cannot evaluate if the voice of a known person is or not familiar. The neural substrate of these two forms of voice recognition is still controversial, but it could concern different components of the core temporal voice areas and of extratemporal voice processing areas. This article reviews recent research on the neuropsychological and anatomo-clinical aspects of this condition.

Recent Findings
Data obtained in group studies or single case reports of phonagnosic patients suggest that apperceptive phonagnosia might be due to disruption of the core temporal voice areas, bilaterally located in the posterior parts of the superior temporal gyrus, whereas associative phonagnosia might result from impaired access to structures where voice representations are stored, due to a disconnection of these areas from structures of the voice extended system.

Summary
Although these results must be confirmed by further investigations, they represent an important step toward understanding the nature and neural substrate of apperceptive and associative forms of phonagnosia.
Transcriptome Sequencing of CeRNA Network Constructing in Status Epilepticus Mice Treated by Low-Frequency Repetitive Transcranial Magnetic Stimulation
Authors: Zhang Shaotian , Zou Huihui , Zou Xiaopei , Ke Jiaqia , Zheng Bofang , Chen Xinrun , Zhou Xianju , Wei Jiana 
Published: May 2023

AbstractIt is shown that great progress was recently made in the treatment of repetitive transcranial magnetic stimulation (rTMS) for neurological and psychiatric diseases. This study aimed to address how rTMS exerted it therapeutic effects by regulating competitive endogenous RNAs (ceRNAs) of lncRNA-miRNA-mRNA. The distinction of lncRNA, miRNA and mRNA expression in male status epilepticus (SE) mice treated by two different ways, low-frequency rTMS (LF-rTMS) vs. sham rTMS, was analyzed by high-throughput sequencing. The Gene Ontology (GO) functional enrichment and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were carried out. Gene–Gene Cross Linkage Network was established; pivotal genes were screened out. qRT-PCR was used to verify gene–gene interactions. Our results showed that there were 1615 lncRNAs, 510 mRNAs, and 17 miRNAs differentially which were expressed between the LF-rTMS group and the sham rTMS group. The expression difference of these lncRNAs, mRNAs, and miRNAs by microarray detection were consistent with the results by qPCR. GO functional enrichment showed that immune-associated molecular mechanisms, biological processes, and GABA-A receptor activity played a role in SE mice treated with LF-rTMS. KEGG pathway enrichment analysis revealed that differentially expressed genes were correlated to T cell receptor signaling pathway, primary immune deficiency and Th17 cell differentiation signaling pathway. Gene–gene cross linkage network was established on the basis of Pearson’s correlation coefficient and miRNA. In conclusion, LF-rTMS alleviates SE through regulating the GABA-A receptor activity transmission, improving immune functions, and biological processes, suggesting the underlying ceRNA molecular mechanisms of LF-rTMS treatment for epilepsy.
SEOM clinical guideline on heritable TP53-related cancer syndrome (2022)
Authors: Sánchez-Heras Ana Beatriz , Ramon y Cajal Teresa , Pineda Marta , Aguirre Elena , Graña Begoña , Chirivella Isabel , Balmaña Judit , Brunet Joan ,   the SEOM Hereditary Cancer Working Group and AEGH Hereditary Cancer Committee
Published: May 2023

AbstractLi-Fraumeni syndrome is caused by heterozygous germline pathogenic variants in the TP53 gene. It involves a high risk of a variety of malignant tumors in childhood and adulthood, the main ones being premenopausal breast cancer, soft tissue sarcomas and osteosarcomas, central nervous system tumors, and adrenocortical carcinomas. The variability of the associated clinical manifestations, which do not always fit the classic criteria of Li-Fraumeni syndrome, has led the concept of SLF to extend to a more overarching cancer predisposition syndrome, termed hereditable TP53-related cancer syndrome (hTP53rc). However, prospective studies are needed to assess genotype–phenotype characteristics, as well as to evaluate and validate risk-adjusted recommendations. This guideline aims to establish the basis for interpreting pathogenic variants in the TP53 gene and provide recommendations for effective screening and prevention of associated cancers in carrier individuals.
Architecture and relationships among cognition, mental health and other human domains revealed by network analysis perspective
Authors: Granziol Umberto , Cona Giorgia 
Published: May 2023

AbstractDespite the connectome or network “era”, the variety of individual facets (e.g., cognition, personality, mental health) are typically studied as separate watertight compartments. This study adopted advanced methodological approaches to (i) highlight a network depicting distinct domains of human mind and behavior, and to (ii) delineate their possible direct influences. Through an Exploratory Graph Analysis on the Human Connectome Project’s database, we found a network composed by seven separate but related domains - Mental Health, Externalizing problems, High-level Cognitive Functions, Basic Cognitive Functions, Substances use/abuse, Reward Delay Discounting and Pain - unveiling a low dimensionality of human mind and behavior. Finally, by applying Bayesian Networks on this model, we observed that some facets have also specific and oriented relationships, while other facets are instead independent from each other. In such a way, we drew a potential architecture of individual’s facets that can pave the way for future neuroimaging studies and clinical practice.
The $$\infty $$-Elastica Problem on a Riemannian Manifold
Authors: Gallagher Ed , Moser Roger 
Published: May 2023

AbstractWe consider the following problem: on any given complete Riemannian manifold (M, g), among all curves which have fixed length as well as fixed endpoints and tangents at the endpoints, minimise the $$L^\infty $$

L
∞

norm of the curvature. We show that the solutions of this problem, as well as a wider class of curves, must satisfy a second-order ODE system. From this system,we obtain some geometric information about the behaviour of the curves.
Association between vascular ultrasound features and DNA sequencing in breast cancer: a preliminary study
Authors: Han Mi-Ryung , Park Ah Young , Seo Bo Kyoung , Bae Min Sun , Kim Jung Sun , Son Gil Soo , Lee Hye Yoon , Chang Young Woo , Cho Kyu Ran , Song Sung Eun , Woo Ok Hee , Ju Hye-Yeon , Oh Hyunseung 
Published: April 2023

AbstractThere are few radiogenomic studies to correlate ultrasound features of breast cancer with genomic changes. We investigated whether vascular ultrasound phenotypes are associated with breast cancer gene profiles for predicting angiogenesis and prognosis. We prospectively correlated quantitative and qualitative features of microvascular ultrasound (vascular index, vessel morphology, distribution, and penetrating vessel) and contrast-enhanced ultrasound (time–intensity curve parameters and enhancement pattern) with genomic characteristics in 31 breast cancers. DNA obtained from breast tumors and normal tissues were analyzed using targeted next-generation sequencing of 105 genes. The single-variant association test was used to identify correlations between vascular ultrasound features and genomic profiles. Chi-square analysis was used to detect single nucleotide polymorphisms (SNPs) associated with ultrasound features by estimating p values and odds ratios (ORs). Eight ultrasound features were significantly associated with 9 SNPs (p < 0.05). Among them, four ultrasound features were positively associated with 5 SNPs: high vascular index with rs1136201 in ERBB2 (p = 0.04, OR = 7.75); large area under the curve on contrast-enhanced ultrasound with rs35597368 in PDGFRA (p = 0.04, OR = 4.07); high peak intensity with rs35597368 in PDGFRA (p = 0.049, OR = 4.05) and rs2305948 in KDR (p = 0.04, OR = 5.10); and long mean transit time with rs2275237 in ARNT (p = 0.02, OR = 10.25) and rs755793 in FGFR2 (p = 0.02, OR = 10.25). We identified 198 non-silent SNPs in 71 various cancer-related genes. Vascular ultrasound features can reflect genomic changes associated with angiogenesis and prognosis in breast cancer.
Clinical utility of polygenic risk scores: a critical 2023 appraisal
Authors: Koch Sebastian , Schmidtke Jörg , Krawczak Michael , Caliebe Amke 
Published: May 2023

AbstractSince their first appearance in the context of schizophrenia and bipolar disorder in 2009, polygenic risk scores (PRSs) have been described for a large number of common complex diseases. However, the clinical utility of PRSs in disease risk assessment or therapeutic decision making is likely limited because PRSs usually only account for the heritable component of a trait and ignore the etiological role of environment and lifestyle. We surveyed the current state of PRSs for various diseases, including breast cancer, diabetes, prostate cancer, coronary artery disease, and Parkinson disease, with an extra focus upon the potential improvement of clinical scores by their combination with PRSs. We observed that the diagnostic and prognostic performance of PRSs alone is consistently low, as expected. Moreover, combining a PRS with a clinical score at best led to moderate improvement of the power of either risk marker. Despite the large number of PRSs reported in the scientific literature, prospective studies of their clinical utility, particularly of the PRS-associated improvement of standard screening or therapeutic procedures, are still rare. In conclusion, the benefit to individual patients or the health care system in general of PRS-based extensions of existing diagnostic or treatment regimens is still difficult to judge.
LANTITE’s impact on teacher diversity: Unintended consequences of testing pre-service teachers
Authors: Hilton Alison L. , Saunders Rebecca 
Published: April 2023

AbstractAustralian schools are diverse, and support students from a wide range of racial, cultural, and linguistic backgrounds, as well as students with disability. Ironically, efforts to ensure equally diverse teacher workforces have been ineffective. Attempts to improve broader representation in teachers have been hampered by a homogenous approach to teacher recruitment and education. In 2016, Literacy and Numeracy Test for Initial Teacher Education (LANTITE) became a graduation requirement for teachers. The aim of this research is to explore the test-taking experiences of students (pre-service teachers) from diverse backgrounds, and the stakeholders who support them. A thematic analysis of data from a larger mixed methods study revealed additional tensions for students from diverse backgrounds including unintended consequences such as traumatic experiences and having to encounter additional hurdles to be successful. This study provides unique insights into additional pressures and hurdles students from diverse backgrounds experience when completing this high-stakes test.
Between Regional Recommendations and National Implementation: An Analysis of the East African Community Partner States’ Legislative Responses to TRIPS Obligations
Authors: Olatunji Olugbenga A. 
Published: May 2023

AbstractWith the access-to-medicines conundrum facing its populations, the East African Community has adopted a policy framework which promotes a collective approach to resolving the access gap in the region. To this end, crucial policy documents on the implementation of TRIPS obligations, harmonisation of drug regulation and boosting regional manufacturing capacity have been adopted. This paper is a case study of the regional policy on the implementation of TRIPS obligations, specifically examining the extent to which partner states’ implementation of TRIPS obligations mirrors the regional recommendations. The paper finds that, while many partner states follow the regional recommendations on implementing TRIPS obligations, coherence remains a big challenge. This, the paper concludes, may affect the overall usefulness of a regional approach to solving the access conundrum.
Multi-criteria comparative analysis of the pressure drop on coal gangue fly-ash slurry at different parts along an L-shaped pipeline
Authors: Wang Defeng , Jiao Dengwu , Cheng Zhanbo , Shi Qingwen , Mischo Helmut 
Published: May 2023

AbstractDisposing of coal gangue and fly-ash on the surface is a risky method with tremendous potential catastrophic consequences for the environment. Backfill mining is a promising practice for turning those hazardous wastes into functional backfill materials. Unfortunately, how to efficiently deliver the slurry to the desired places remains under-researched. To address this issue, the computational fluid dynamics software Fluent was used in the current study in addition to a laboratory rheological test to simulate the impact of various parameters on the evolution of pressure at a particular section of the pipeline. Furthermore, the response surface method was employed to investigate how the various components and their corresponding influencing weights interact to affect the pressure drop. This study demonstrates that the pressure drop of the slurry is highly influenced by slurry concentration, speed, and pipe diameter. While conveying speed is the main component in the bend section, pipe diameter takes over in the horizontal and vertical pipe sections.