bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of abiotic elicitor methyl jasmonate on production of rutin in callus cultures of Abutilon hirtum L.
Authors: Nadir Dhuha Sabah , Alwan Alhan Mohammed 
Published: December 2022

A significant therapeutic plant from the Malvaceae family is Abutilon hirtum (L.). It is frequently used in traditional medicine to treat a variety of illnesses. Rutin is a flavonoid molecule with commercial value that has anticancer, nutritional, and anti-ageing properties. This research project was carried out to evaluate the effect of abiotic elicitor Methyl Jasmonate (MeJA) at concentrations 0.0, 0.01, 0.02, 0.03 mmol.L-1 on accumulation of rutin by callus cultures of Abutilon hirtum L. after 30 days of growth on Murashige and Skoog (MS) medium to which 2000 µg.L-1 2,4-Dichlorophenoxy acetic acid (2,4-D) + 500 µg.L-1 Kinetin (Kin) were added. The results showed that the best callus stems cultivated on MS growth medium fortified with 2000 µg.L-1 2,4-D + 500 µg.L-1 Kin, recorded the highest fresh weight of 2.887 g after four weeks. This induced callus was characterized by its friable texture. The data of rutin detection in cultures of callus obtained from stems explant of A. hirtum L., using High-Performance Liquid Chromatography (HPLC) indicated the presence of rutin in these cultures by comparison with the rutin standard samples containing a precisely known concentration of a substance for use in quantitative analysis.. Treatment with 0.03 mmol.L-1 of Methyl Jasmonate gave the best rutin amount of 5.606 mg.g-1 was much higher than the control treatment of 1.569 mg.g-1. These data clearly indicated that callus cultures are a potential continuous and constant source of rutin, as a secondary metabolite, and as an alternative to field plants.
Descriptive, Prospective Observational Study- Studying Possible Prediction Factors for Disease Severity and Progression among a Sample of COVD 19 Patients in Iraq
Authors: Habeeb Duaa Mohammed , Zinah M. Anwer  
Published: December 2022

Abstract
Coronavirus has affected many people around the world and caused an increase in the number of hospitalized patients and deaths. The prediction factor may help the physician to classify whether the patient needs more medical attention to decrease mortality and worsening of symptoms. We aimed to study the possible relationship between C reactive protein level and the severity of symptoms and its effect on the prognosis of the disease. And determine patients who require closer respiratory monitoring and more aggressive supportive therapies to avoid poor prognosis. The data was gathered using medical record data, the patient's medical history, and the onset of symptoms, as well as a blood sample to test the C-reactive protein level. The patients were divided into three groups based on the severity of the disease. A prospective cohort study of 246 patients over the age of 18 years discovered that c-reactive protein levels were significantly higher in more severe cases than in mild cases, and that older patients with high levels of AST, TSB, Urea, Creatinine, and CRP were associated with the need for a high flow of oxygen, an intensive care unit, a longer length of hospitalization, and a have a high mortality rate. The study concluded several predictor factors for the disease (COVID-19) severity, duration of hospitalization, ICU admission and need for oxygen therapy.
Comparative analysis of the collection winter barley samples in the Rostov region
Authors: Doroshenko E. S. , Filippov E. G. 
Published: December 2022

The main task for the near future is to identify the best samples from the collection to develop the winter barley varieties that meet the modern requirements of domestic agricultural producers. The purpose of the study was to identify the effect of the yield structural elements and other traits on the productivity of collection winter barley varieties and to identify the most adapted for use in the breeding process. The current paper has presented the study results of collection winter barley samples. The study was carried out in the department of barley breeding and seed production of the FSBSI Agricultural Research Center «Donskoy» (2018–2021). Based on the study results of this material, there were identified new sources for use in breeding programs to increase the values of individual traits:– low stem: ‘Perkins’ (USA), ‘Novosadski 331’ (Yugoslavia);– resistance to lodging: ‘Hobbit’ (Switzerland), ‘Merchant’ (Bulgaria), ‘Akademichesky’ (Ukraine), ‘Gust’ (Belarus), ‘18513 EN11’ (France), ‘Explorer 2’, ‘Explorer 3’, ‘Explorer 4’, ‘Explorer 6’, ‘Explorer 8’, ‘Wintwalt’, ‘Tiffani’ (Germany), ‘Perkins’ (USA), ‘Novosadski 331’ (Yugoslavia), ‘Posaune’, ‘Sombrero’, ‘Karisma’ (England), ‘Duet’ (Germany);– number of productive stems per area unit: ‘Explorer 8’, ‘Explorer 4/2’, ‘Wintwalt’ (Germany), ‘Baraka’ (France), ‘Posaune’ (England);– grain content per head: ‘Artel’ (Russia), ‘Caprice’, ‘Azurel’, ‘Rurdue’ (France), ‘HWV1427’ (Germany);– 1000-grain weight: ‘Randevu’, ‘Premier’ (Russia), ‘Nectaria’, ‘Vanessa’ (France), ‘Explorer 3’ (Germany);– grain weight per head: ‘Randevu’, ‘Pallidum 1916’ (Russia), ‘Oribi’, ‘Bezosty’ (France), ‘Explorer 2’, ‘KWS-Scala’ (Germany), ‘Hobbit’ (Switzerland);– fast-maturity: ‘Parallelum 1963’, ‘Sekret,’ ‘Bezosty 1953’, ‘Bezosty 1954’ (Russia), ‘Fermer’ (Ukraine);– high productivity: ‘Rostovsky 55’, ‘Grand’, ‘Artel’ (Russia), ‘KWS-Hiskory’, ‘Explorer 8’ (Germany), ‘Esterel’ (France).According to the complex of economically valuable traits (4 or more traits), there were identified 15 varieties: ‘Randevu’, ‘Parallelum 1960’ (Russia), ‘KWS-Scala’, ‘KWS-2-117’, ‘KWS-2-234’, ‘Explorer 4’, ‘Explorer 3/2’ (Germany), ‘Baraka’, ‘Rebelle’, ‘6577 CH’, ‘18513 EH11’ (France), ‘Cello’, ‘Fenesse’ (USA), ‘Novosadski 321’ (Yugoslavia), ‘Posaune’ (England).
Gerakan Solidaritas Pada Masa Pandemi Covid-19 Sebagai Wujud Wajah Sosial Gereja
Authors: Sugiyana Fransiskus Xaverius , Setiyaningtiyas Nerita 
Published: December 2022

<p><strong>Abstract: </strong>This research was a descriptive qualitative study based on the pastoral work of the data-driven concerning Church experiences during the Covid-19 pandemic. Departing from various solidarity initiatives, this study showed that the efficiency and effectiveness of pastoral work began with a social analysis of the problems. The mapped problems brought an insight on how pastoral plan should be done. The hope is that the arranged programs can have measurable results and real impact. The first focus of this research was the pattern of solidarity movements. The second focus is the face of the Church that appears in the community and society. Data collection employed descriptive qualitative methods. Data analysis used content analysis approach. The first findings showed that parishioners of the kevikepan Semarang concerned with economic recovery and psychological assistance. The second finding showed that the solidarity movement revealed the social faced of the Church. In the missionary spirit, the Church showed sensitivity to social issues due to the Covid-19 pandemic. The Church also appeared to have a spirit of compassion, care and a high willingness to share. The involving people with all backgrounds who were in solidarity movement was a sign of the presence of the Kingdom of God. The act of solidarity can really bring transformation for each person involved in it.</p><p><strong>Key words</strong>: Pastoral Theology; Capital Social; Altruism; Catholic Social Teaching; Semarang</p>
Intraoperative valence testing to adjudicate between ventral capsule/ventral striatum and bed nucleus of the stria terminalis target selection in deep brain stimulation for obsessive-compulsive disorder
Authors: Shofty Ben , Gadot Ron , Viswanathan Ashwin , Provenza Nicole R. , Storch Eric A. , McKay Sarah A. , Meyers Matthew S. , Hertz Alyssa G. , Avendano-Ortega Michelle , Goodman Wayne K. , Sheth Sameer A. 
Published: December 2022

OBJECTIVE
Deep brain stimulation (DBS) is an accepted therapy for severe, treatment-refractory obsessive-compulsive disorder (trOCD). The optimal DBS target location within the anterior limb of the internal capsule, particularly along the anterior-posterior axis, remains elusive. Empirical evidence from several studies in the past decade has suggested that the ideal target lies in the vicinity of the anterior commissure (AC), either just anterior to the AC, above the ventral striatum (VS), or just posterior to the AC, above the bed nucleus of the stria terminalis (BNST). Various methods have been utilized to optimize target selection for trOCD DBS. The authors describe their practice of planning trajectories to both the VS and BNST and adjudicating between them with awake intraoperative valence testing to individualize permanent target selection.

METHODS
Eight patients with trOCD underwent awake DBS with trajectories planned for both VS and BNST targets bilaterally. The authors intraoperatively assessed the acute effects of stimulation on mood, energy, and anxiety and implanted the trajectory with the most reliable positive valence responses and least stimulation-induced side effects. The method of intraoperative target adjudication is described, and the OCD outcome at last follow-up is reported.

RESULTS
The mean patient age at surgery was 41.25 ± 15.1 years, and the mean disease duration was 22.75 ± 10.2 years. The median preoperative Yale-Brown Obsessive Compulsive Scale (Y-BOCS) score was 39 (range 34–40). Two patients had previously undergone capsulotomy, with insufficient response. Seven (44%) of 16 leads were moved to the second target based on intraoperative stimulation findings, 4 of them to avoid strong negative valence effects. Three patients had an asymmetric implant (1 lead in each target). All 8 patients (100%) met full response criteria, and the mean Y-BOCS score reduction across the full cohort was 51.2% ± 12.8%.

CONCLUSIONS
Planning and intraoperatively testing trajectories flanking the AC—superjacent to the VS anteriorly and to the BNST posteriorly—allowed identification of positive valence responses and acute adverse effects. Awake testing helped to select between possible trajectories and identify individually optimized targets in DBS for trOCD.
Predicting glioblastoma molecular subtypes and prognosis with a multimodal model integrating convolutional neural network, radiomics, and semantics
Authors: Zhong Sheng , Ren Jia-Xin , Yu Ze-Peng , Peng Yi-Da , Yu Cheng-Wei , Deng Davy , Xie YangYiran , He Zhen-Qiang , Duan Hao , Wu Bo , Li Hui , Yang Wen-Zhuo , Bai Yang , Sai Ke , Chen Yin-Sheng , Guo Cheng-Cheng , Li De-Pei , Cheng Ye , Zhang Xiang-Heng , Mou Yong-Gao 
Published: December 2022

OBJECTIVE
The aim of this study was to build a convolutional neural network (CNN)–based prediction model of glioblastoma (GBM) molecular subtype diagnosis and prognosis with multimodal features.

METHODS
In total, 222 GBM patients were included in the training set from Sun Yat-sen University Cancer Center (SYSUCC) and 107 GBM patients were included in the validation set from SYSUCC, Xuanwu Hospital Capital Medical University, and the First Hospital of Jilin University. The multimodal model was trained with MR images (pre- and postcontrast T1-weighted images and T2-weighted images), corresponding MRI impression, and clinical patient information. First, the original images were segmented using the Multimodal Brain Tumor Image Segmentation Benchmark toolkit. Convolutional features were extracted using 3D residual deep neural network (ResNet50) and convolutional 3D (C3D). Radiomic features were extracted using pyradiomics. Report texts were converted to word embedding using word2vec. These three types of features were then integrated to train neural networks. Accuracy, precision, recall, and F1-score were used to evaluate the model performance.

RESULTS
The C3D-based model yielded the highest accuracy of 91.11% in the prediction of IDH1 mutation status. Importantly, the addition of semantics improved precision by 11.21% and recall in MGMT promoter methylation status prediction by 14.28%. The areas under the receiver operating characteristic curves of the C3D-based model in the IDH1, ATRX, MGMT, and 1-year prognosis groups were 0.976, 0.953, 0.955, and 0.976, respectively. In external validation, the C3D-based model showed significant improvement in accuracy in the IDH1, ATRX, MGMT, and 1-year prognosis groups, which were 88.30%, 76.67%, 85.71%, and 85.71%, respectively (compared with 3D ResNet50: 83.51%, 66.67%, 82.14%, and 70.79%, respectively).

CONCLUSIONS
The authors propose a novel multimodal model integrating C3D, radiomics, and semantics, which had a great performance in predicting IDH1, ATRX, and MGMT molecular subtypes and the 1-year prognosis of GBM.
Evaluasi Kualitas Mutu Pembangunan Infrastruktur Pedesaan Khusus Alokasi Dana Desa (ADD 2019) Studi Kasus : Kecamatan Depati Tujuh
Authors: Aura Zalsa Glodea , Nurdin Ade , Nuklirullah M 
Published: December 2022

Sebagai Engineer kualitas suatu pembangunan dilihat dari perencanaan dan pengendalian pekerjaan agar mencapai pembangunan yang baik. Kualitas produk akhir dan tidak terpenuhi, bangunan berimplikasi pada umur struktur di karenakan Penyimpangan prosedur pekerjaan yang seringkali diabaikan oleh masyarakat, menjadikan harapan kualitas akhir produk tidak dapat tercapai. Dalam menunjang kesejahteraan masyarakat desa maka perencanaan dan pengadaan meliputi identifikasi kebutuhan dalam bentuk fasilitas konstruksi yang berkualitas yang bisa di gunakan dalam umur panjang untuk tercapainya keinginan masyarakat yang di harapkan oleh pemerintah desa. Untuk itu di harapkan dalam penggerakan pengujian mutu harus diutamakan dalam bidang struktur agar infrastruktur yang di harapkan tercapai pada umur rencana dan memuaskan. di wilayah Kecamatan Depati Tujuh yang terletak di kabupaten kerinci yang merupakan wilayah pertanian memerlukan perhatian dari aspek mutu pembangunan yang di terapkan pada perencanaan dan pelaksanaan. Pelaksanaan pembangunan pada pedesaan yang merupakan pembangunan lepas yang biasanya sering di lakukan oleh pihak desa saja tidak ada penggunaan jasa manajemen konstruksi. Bertepatan dari hal itu maka pengendalian proyek yang di lakukan oleh desa dilakukan dengan seadanya, dan mengandalkan pendamping desa untuk mengendali pelaksanaan proyek.
Extending properly n - REA sets1
Authors: Cholak Peter , Gerdes Peter 
Published: December 2022

In 1982, Soare and Stob proved that if A is an r.e. set which isn’t computable then there is a set of the form A ⊕ W e which isn’t of r.e. Turing degree. If we define a properly n + 1-REA set to be an n + 1-REA set which isn’t Turing equivalent to any n-REA set this result shows that every properly 1-REA set can be extended to a properly 2-REA set. This result was extended by Cholak and Hinman in 1994. They proved that every 2-REA set can be extended to a properly 3-REA set. This leads naturally to the hypothesis that every properly n-REA set can be extended to a properly n + 1-REA set. Here we show this hypothesis is false and that there is a properly 3-REA set which can’t be extended to a properly 4-REA set. Moreover we show this set A can be Δ 2 0 .
Penggunaan Model Role Plating dalam Pembelajaran PAK
Authors: Ina Astuti Tamu , Njakatamu Isramirawati Njuala 
Published: December 2022

Pendidikan adalah proses pengubahan sikap dan tingkah laku seseorang yang dilakukan secara sengaja dan terencana melalui pengembangan potensi yang dimiliki seseorang. Maka Pendidikan Agama Kristen mengambil peranan dalam sekolah supaya memiliki kualitas moral yang baik sesuai dengan harapan Tuhan serta menjadi pengikut Kristus. Namun mengajarkan Pendidikan Agama Kristen tidaklah muda. Guru PAK memiliki tanggung jawab besar dalam kelangsungan proses pembelajaran. Guru PAK harus memastikan bahwa pembelajaran harus berjalan efektif. Oleh karena itu, guru harus menguasai startegi/teknik, metode, maupun model pembelajaran sehingga dapat menolong siswa untuk memahami materi yang diajarkan khususnya dalam pembelajaran PAK. Maka dengan demikian untuk dapat meningkatkan hasil belajar siswa perlu dibutuhkan satu keseriusan dalam mengajar serta menggunakan metode yang kreatif. Penulis mengambil penelitian dengan penerapan model role playing. Dari kajian teori diketahui bahwa model role playing berpengaruh terhadap hasil belajar. Dan dari pengolahan data di lapangan, diketahui bahwa pengaruh penerapan model role playing terhadap hasil belajar adalah 31%. Hal ini didukung oleh uji hipotesa dalam penelitian ini, menyatakan H0 ditolak H1 diterima yaitu T hitung 3,015 T tabel 1,73. Penerapan model role playing adalah terdiri dari beberapa tahapan yaitu pemanasan diamana pendidik menjelaskan cerita yang akan di perankan, pemilihan peran yaitu guru memilih siswa untuk menjadi peran, penataan tempat dimana guru mempersiapkan tempat yang akan dipergunakan untuk bermain peran, pemilihan pengamat yaitu guru memilih siswa sebagai pengamat, memulai pemeranan dimana siswa memulai bermain peran, evaluasi pertama adalah guru bersama pengamat serta pemain peran mengevaluasi pemeranan yang telah dilakukan, pengulangan pemeranan yaitu memperbaiki pemeranan yang pertama, evaluasi kedua membahas pemeranan dan guru menjelaskan mengenai nilai kebenaran pada setiap pemeranan , dan kesimpulannya yaitu siswa diajak berbagi pengalaman pada saat bermain peran serta menyimpulkan dari semua kegiatan yang telah dilakukan.
Kegiatan Belajar dan Mengajar secara Digital dengan Konsep Hybrid Learning di Sekolah Terpadu Pahoa
Authors: Tjoeng Diana , Sutrisno Sutrisno , Hutabarat Christiani , Putrawan Bobby Kurnia 
Published: December 2022

The Covid-19 pandemic has changed the order of people's lives in all aspects of life, one of which is in the world of education, especially in the world of Christian Religious Education. The face-to-face learning model has now turned into distance learning or also known as online learning. Looking at the current development of education, the researcher observes that blended learning or hybrid learning systems can be applied in the learning process. This research was conducted at the Pahoa Integrated School. The approach in this study uses a qualitative approach. The data is taken by looking directly through online and face-to-face teaching and learning activities so that definite data can be obtained. The results of this study found that digital teaching and learning activities with the concept of Hybrid Learning were good. For example, in school, teachers improve their ability to master technology because all learning is done using digital learning technology. The parents received a good response, especially for busy parents who did not have time to accompany students to study at home and for students to have the opportunity to return to learning to socialize and explore themselves with friends at school, even if only for a short time given the restrictions. The number of students in the class and the limitation of learning time in the class. AbstrakMasa Pandemi Covid-19 berdampak merubah tatanan kehidupan masyarakat dalam segala aspek kehidupan salah satunya dalam dunia pendidikan, terlebih khusus nya terhadap dunia Pendidikan Agama Kristen. Model pembelajaran dilakukan secara tatap muka kini berubah menjadi pembelajaran jarak jauh atau disebut juga pembelajaran dalam jaringan (daring/online). Melihat perkembangan Pendidikan sekarang ini maka peneliti mengamati bahwa sistem pembelajaran blended learning atau hybrid learning dapat di terapkan dalam proses pembelajaran. Penelitian ini dilaksanakan di Sekolah Terpadu Pahoa. Pendekatan dalam penelitian ini menggunakan pendekatan kualitatif. Data diambil dengan melihat secara langsung melalui kegiatan belajar mengajar online dan tatap muka sehingga dapat di peroleh data yang pasti. Hasil penelitian ini didapatkan bahwa kegiatan belajar mengajar digital dengan konsep Hybrid Learning adalah baik. Misalnya dari pihak sekolah, para guru meningkatkan kemampuan dirinya dalam menguasai teknologi karena semua pembelajaran dilakukan menggunakan teknologi pembelajaran digital. Pihak orangtua mendapatkan tanggapan dan respon yang baik terlebih lagi bagi para orangtua yang sibuk tidak sempat menemani siswa untuk belajar di rumah, dan bagi siswa mendapatkan kesempatan kembali untuk belajar bersosialisasi dan mengeksplorasi dirinya bersama teman-teman di sekolah sekalipun hanya dalam waktu singkat mengingat adanya pembatasan jumlah siswa didalam kelas dan pembatasan waktu pembelajaran didalam kelas.
Penerapan Teknik Self-Regulated Learning dalam Pembelajaran Daring
Authors: Zain Diana Meita , Lindinau Marcelinus 
Published: December 2022

Self-regulated learning is self-regulating skills to set goals, evaluate and make the necessary adaptations. This technique can optimize online learning, indicating tiring and multitasking. This study aims to determine how STIPAK students, especially those from the TFN program, use self-regulated learning techniques to optimize online learning. This type of research is qualitative with a phenomenological approach; the number of informants studied is six people. The results showed that all the informants had implemented several SRL strategies. However, only three people (LPA, YSE, and ASN) did with 3 SRL strategies, and only one informant, namely ASN, did with the choice of an effective SRL strategy. The researcher's suggestion, it is necessary to develop students to increase online learning to be more optimal. AbstrakSelf-regulated learning adalah keterampilan mengatur diri untuk menetapkan tujuan, mengevaluasi dan membuat adaptasi yang diperlukan. Teknik ini dapat mengoptimalkan proses belajar secara daring yang mengindikasikan melelahkan dan banyak tugas. Penelitian ini bertujuan untuk mengetahui bagaimanakah mahasiswa STIPAK khususnya dari program TFN dalam mengunakan teknik self-regulated learning (SLR) sebagai cara mengoptimalisasikan pembelajaran daring. Jenis penelitian ini adalah kualitatif dengan pendekatan fenomenologi, informan yang diteliti berjumlah 6 orang. Hasil penelitian menunjukkan bahwa semua informan telah melakukan beberapa strategi SRL. Namun hanya tiga orang (LPA, YSE dan ASN) yang melakukan dengan 3 strategi SRL dan hanya 1 informan yaitu ASN yang melakukan dengan pilihan strategi SRL yang efektif. Saran peneliti adalah perlu pembinaan mahasiswa agar ada peningkatan SRL supaya pebelajaran daring lebih optimal.