bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transmission risk of Oropouche fever across the Americas
Authors: Romero-Alvarez Daniel , Escobar Luis E. , Auguste Albert J. , Del Valle Sara Y. , Manore Carrie A. 
Published: May 2023

AbstractBackgroundVector-borne diseases (VBDs) are important contributors to the global burden of infectious diseases due to their epidemic potential, which can result in significant population and economic impacts. Oropouche fever, caused by Oropouche virus (OROV), is an understudied zoonotic VBD febrile illness reported in Central and South America. The epidemic potential and areas of likely OROV spread remain unexplored, limiting capacities to improve epidemiological surveillance.MethodsTo better understand the capacity for spread of OROV, we developed spatial epidemiology models using human outbreaks as OROV transmission-locality data, coupled with high-resolution satellite-derived vegetation phenology. Data were integrated using hypervolume modeling to infer likely areas of OROV transmission and emergence across the Americas.ResultsModels based on one-support vector machine hypervolumes consistently predicted risk areas for OROV transmission across the tropics of Latin America despite the inclusion of different parameters such as different study areas and environmental predictors. Models estimate that up to 5 million people are at risk of exposure to OROV. Nevertheless, the limited epidemiological data available generates uncertainty in projections. For example, some outbreaks have occurred under climatic conditions outside those where most transmission events occur. The distribution models also revealed that landscape variation, expressed as vegetation loss, is linked to OROV outbreaks.ConclusionsHotspots of OROV transmission risk were detected along the tropics of South America. Vegetation loss might be a driver of Oropouche fever emergence. Modeling based on hypervolumes in spatial epidemiology might be considered an exploratory tool for analyzing data-limited emerging infectious diseases for which little understanding exists on their sylvatic cycles. OROV transmission risk maps can be used to improve surveillance, investigate OROV ecology and epidemiology, and inform early detection.
Assessing the effects of hyperparameters on knowledge graph embedding quality
Authors: Lloyd Oliver , Liu Yi , R. Gaunt Tom 
Published: May 2023

AbstractEmbedding knowledge graphs into low-dimensional spaces is a popular method for applying approaches, such as link prediction or node classification, to these databases. This embedding process is very costly in terms of both computational time and space. Part of the reason for this is the optimisation of hyperparameters, which involves repeatedly sampling, by random, guided, or brute-force selection, from a large hyperparameter space and testing the resulting embeddings for their quality. However, not all hyperparameters in this search space will be equally important. In fact, with prior knowledge of the relative importance of the hyperparameters, some could be eliminated from the search altogether without significantly impacting the overall quality of the outputted embeddings. To this end, we ran a Sobol sensitivity analysis to evaluate the effects of tuning different hyperparameters on the variance of embedding quality. This was achieved by performing thousands of embedding trials, each time measuring the quality of embeddings produced by different hyperparameter configurations. We regressed the embedding quality on those hyperparameter configurations, using this model to generate Sobol sensitivity indices for each of the hyperparameters. By evaluating the correlation between Sobol indices, we find substantial variability in the hyperparameter sensitivities between knowledge graphs with differing dataset characteristics as the probable cause of these inconsistencies. As an additional contribution of this work we identify several relations in the UMLS knowledge graph that may cause data leakage via inverse relations, and derive and present UMLS-43, a leakage-robust variant of that graph.
Exercise Promotes Tissue Regeneration: Mechanisms Involved and Therapeutic Scope
Authors: Liu Chang , Wu Xinying , Vulugundam Gururaja , Gokulnath Priyanka , Li Guoping , Xiao Junjie 
Published: May 2023

AbstractExercise has well-recognized beneficial effects on the whole body. Previous studies suggest that exercise could promote tissue regeneration and repair in various organs. In this review, we have summarized the major effects of exercise on tissue regeneration primarily mediated by stem cells and progenitor cells in skeletal muscle, nervous system, and vascular system. The protective function of exercise-induced stem cell activation under pathological conditions and aging in different organs have also been discussed in detail. Moreover, we have described the primary molecular mechanisms involved in exercise-induced tissue regeneration, including the roles of growth factors, signaling pathways, oxidative stress, metabolic factors, and non-coding RNAs. We have also summarized therapeutic approaches that target crucial signaling pathways and molecules responsible for exercise-induced tissue regeneration, such as IGF1, PI3K, and microRNAs. Collectively, the comprehensive understanding of exercise-induced tissue regeneration will facilitate the discovery of novel drug targets and therapeutic strategies.
Intelligent design: stablecoins (in)stability and collateral during market turbulence
Authors: De Blasis Riccardo , Galati Luca , Webb Alexander , Webb Robert I. 
Published: May 2023

AbstractHow does stablecoin design affect market behavior during turbulent periods? Stablecoins attempt to maintain a “stable” peg to the US dollar, but do so with widely varying structural designs. The spectacular collapse of the TerraUSD (UST) stablecoin and the linked Terra (LUNA) token in May 2022 precipitated a series of reactions across major stablecoins, with some experiencing a fall in value and others gaining value. Using a Baba, Engle, Kraft and Kroner (1990) (BEKK) model, we examine the reaction to this exogenous shock and find significant contagion effects from the UST collapse, likely partially due to herding behavior among traders. We test the varying reactions among stablecoins and find that stablecoin design differences affect the direction, magnitude, and duration of the response to shocks. We discuss the implications for stablecoin developers, exchanges, traders, and regulators.
Myelin degradation, axonal changes and expression trajectories of glial cells stimulated by rapid head insult in humans to estimate approximate time elapsed since trauma
Authors: Sharma Meenakshi , Subramanian Arulselvi , Suri Vaishali , Mathur Purva , Prakash Shyam , Chakraborty Nabarun , Agrawal Deepak , Pandey R. M. , Raina Anupuma , Malhotra Rajesh , Lalwani Sanjeev 
Published: May 2023

Abstract
Background
Post severe traumatic brain injury (sTBI), axonal alterations lead to myelin loss and its degeneration. In the recovery phase, numerous intermingled biochemical pathways involving complex inflammatory reactions cloud the understanding of this yet undiscerned process that also varies with agonal period. In cases with dubious histories, approximating the survival time can be challenging, and expression levels of characteristic markers may aid forensic experts in the same.

Methods
This exploratory study recruited 100 samples—68 sTBI, 22 non-TBI and 10 age- and sex-matched control samples. Male:female ratio was 87:13. Histochemical staining using H&E was used to characterize myelination pattern, and IHC of GFAP and CD-68 were performed to assess astroglial and microglial reactions with respect to survival time in specific sites.

Result
Among sTBI, non-TBI and control recruits, sTBI patients depicted significant myelination abnormalities, astroglial proliferation and microglial reaction and varying with survival time. Non-TBI and control samples depicted nearly similar profiles.

Conclusion
In order to untangle the complex mesh of biochemical responses, nuanced research on individual factors (both pre- and post mortem) with regard to specific site and survival time are warranted. Standardizing experimental data and converting it into empirical data shall aid forensic experts in suggesting approximate agonal period.
Buying electricity resilience: using backup generator sales in the United States to understand the role of the private market in resilience
Authors: Thompson Daniel , Pescaroli Gianluca 
Published: May 2023

AbstractDisruptions to key lifelines, especially electrical power, can cause outsized impacts on human functioning. The state of the art on developed countries has focused on enhancing resilience to electrical grid infrastructure but has neglected to track changes regarding how the private market has developed electricity continuity measures over time. Backup generators are among the most accessible tools to maintain electricity continuity in case of power failure, but their role as a buffer remains understudied outside the technical domain, along with the humanitarian and emergency response sectors.This paper analyzes generator sales across the U.S. to understand some underlying trends that may have influenced changes in consumer preference for electricity resilience. Reports from major backup generator sellers and import data of backup generators reveal an increase in backup generators across the U.S. and find that private demand for energy resilience is likely increasing due to consumers’ perceived risk and rising levels of intolerance to power disruptions. The discussion finds that an increase in private demand and use of backup generators may be impacting electricity resilience at a communal and societal level, which seems to be underexamined by studies focusing on private generator usage in the U.S..
Mid-regional proadrenomedullin as a potential prognostic factor of NIV outcome in AECOPD
Authors: Elnady Mohamed Abd El Hakim , Assal Hebatallah Hany , Kandeel Reham Hassan , Elaguizy Menatallah Mohamed , Elwafa Gihan Saad Abo 
Published: May 2023

Abstract
Background
Early prediction of non-invasive ventilation failure by using clinical parameters and scoring systems is a promising strategy for reducing mortality in acute exacerbation of chronic obstructive pulmonary disease patients. Our aim was to assess predictors of non-invasive ventilation failure in acute exacerbation of chronic obstructive pulmonary disease and the prognostic role of mid-regional proadrenomedullin.

Results
Forty-five patients were enrolled, comprising thirty-six males and nine females with mean age 63.4 ± 9.22 years. Mid-regional proadrenomedullin could not predict non-invasive ventilation outcome, while acute physiology and chronic health evaluation score, blood pH, arterial carbon dioxide and platelet count had predictive value.

Conclusion
Prediction of non-invasive ventilation outcome in acute exacerbation of chronic obstructive pulmonary disease patients is multifactorial and mid-regional proadrenomedullin alone could not predict this outcome.
Long-Term Risk of Being Bedridden in Elderly Patients Who Underwent Oncologic Surgery: A Retrospective Study Using a Japanese Claims Database
Authors: Konishi Takaaki , Sasabuchi Yusuke , Matsui Hiroki , Tanabe Masahiko , Seto Yasuyuki , Yasunaga Hideo 
Published: May 2023

Abstract
Background
Although functional outcomes are important in surgery for elderly patients, the long-term functional prognosis following oncologic surgery is unclear. We retrospectively investigated the long-term, functional and survival prognosis following major oncologic surgery according to age among elderly patients.

Methods
We used a Japanese administrative database to identify 11,896 patients aged ≥ 65 years who underwent major oncological surgery between June 2014 and February 2019. We investigated the association between age at surgery and the postoperative incidence of bedridden status and mortality. Using the Fine–Gray model and restricted cubic spline functions, we conducted a multivariable, survival analysis with adjustments for patient background characteristics and treatment courses to estimate hazard ratios for the outcomes.

Results
During a median follow-up of 588 (interquartile range, 267–997) days, 657 patients (5.5%) became bedridden and 1540 (13%) died. Patients aged ≥ 70 years had a significantly higher incidence of being bedridden than those aged 65–69 years; the subdistribution hazard ratios of the age groups of 70–74, 75–79, 80–84, and ≥ 85 years were 3.20 (95% confidence interval [CI], 1.53–6.71), 3.86 (95% CI 1.89–7.89), 6.26 (95% CI 3.06–12.8), and 8.60 (95% CI 4.19–17.7), respectively. Restricted cubic spline analysis demonstrated an increase in the incidence of bedridden status in patients aged ≥ 65 years, whereas mortality increased in patients aged ≥ 75 years.

Conclusions
This large-scale, observational study revealed that older age at oncological surgery was associated with poorer functional outcomes and higher mortality among patients aged ≥ 65 years.
Inhibiting Factors for Collaborative Water Governance: A Case Study of Mount Merapi Ecosystem in Yogyakarta, Indonesia
Authors: Harjanta Sri Lestari , Ningrum Dyaloka Puspita 
Published: May 2023

The ecosystem around Mount Merapi, Indonesia, has many potential water sources. Still, poor management and a decrease in springs may lead to a water crisis in 2029 that could affect millions of residents in Yogyakarta, Indonesia. This study aims to identify the inhibiting factors for collaborative water governance under the threat of a water crisis. This research used qualitative descriptive research with data collected through interviews, documents, and observations. The analysis involved data reduction, presentation, and conclusion drawing/verification to explore Yogyakarta's water management aspects. The study suggests that collaborative water governance involving multiple stakeholders, including non-government actors, is crucial for effective water management. The local government dominates water management, while private and community groups have minimal involvement. There is a need for more specific regulations that comprehensively regulate water management and conservation efforts in the regions. Water management in Yogyakarta is classified under traditional governance due to the limited involvement of non-government actors and the minimal participation space provided by the regional government. A comprehensive regulation is needed to address water conservation, and complete collaboration among stakeholders is necessary to overcome obstacles in the water management crisis.
The technology acceptance model and beyond: factors influencing physicians' intention to use teleconsultations
Authors: Ranjeni S , Vasumathi P , Arun Joe 
Published: May 2023

Background/Aims The COVID-19 pandemic accelerated the implementation of telehealth and virtual care services. Clinicians must be comfortable using this technology in order for it to be developed effectively and implemented consistently. This study evaluated the influence of various factors, including those theorised in the technology acceptance model, on physicians' intention to use teleconsultations in their clinical practice in Chennai, India. Methods A snowball sampling method was used to distribute an online survey to physicians in Chennai, India. The survey measured respondents' intention to use teleconsultations (dependent variable), along seven independent variables relating to this technology (perceived usefulness, perceived ease of use, physicians' attitudes, social influences, facilitating conditions, perceived compatibility with the clinical area and trust). A total of 165 responses were collected. Results were analysed using descriptive and correlational statistics, along with multiple linear regression. Results All seven independent variables were found to be significantly associated with the dependent variable (P<0.01). Multiple linear regression analysis indicated that the independent variables accounted for 67.8% of the variance in respondents' intention to use teleconsultations. Conclusions Physicians' intention to use teleconsultations is complex and multi-faceted. Although the factors theorised by the technology acceptance model were significantly associated with intention to use telemedicine, other factors were also found to be important, including social influences, external facilitating factors, perceived compatibility with the clinical area and personal trust in technology.
Metal on Merseyside: Music Scenes, Community and Locality, Nedim Hassan (2021)
Authors: Kärki Kimi 
Published: May 2023

Review of: Metal on Merseyside: Music Scenes, Community and Locality, Nedim Hassan (2021)
Cham: Palgrave Macmillan, 221 pp.,
ISBN 978-3-03077-680-0, e-book, £43.99
Le Hellfest: Un pèlerinage pour metalheads (Hellfest: A Pilgrimage for Metalheads), Corentin Charbonnier (2017)
Authors: Farvaque Etienne 
Published: May 2023

Review of: Le Hellfest: Un pèlerinage pour metalheads (Hellfest: A Pilgrimage for Metalheads), Corentin Charbonnier (2017)
Azay-sur-Cher: Corentin Charbonnier éditions, 208 pp.,
ISBN 978-2-95587-890-3, p/bk, €17
effects of increased body mass index on preconception health
Authors: Petročnik Petra , Prosen Mirko , Mivšek Ana Polona 
Published: May 2023

Introduction: The growing proportion of overweight and obese people worldwide is of great concern as it affects the overall health of people and consequently also their reproductive health. The aim of this literature review is to examine how increased body mass index affects fertility and preconception health in men and women.Methods: A scoping literature review was conducted in February 2021 using PubMed and Medline databases, as well as the Google Scholar search engine. Inclusion criteria consisted of scientific literature, regardless of methodology, and articles published in Slovene and English.Results: The literature search yielded 9 reviews and 5 original quantitative studies published in English in the last 15 years. The results suggest that there is compelling evidence that obese individuals are at increased risk of various health problems in the pre-conception period that may affect their fertility and ability to conceive.Discussion and conclusion: The rising prevalence of high body mass index is changing the reproductive health of men and women. Growing obesity rates, particularly in the Western world, call for greater awareness of this metabolic syndrome and its impact on female and male reproduction. Health professionals working with couples in the pre-conception period should have sufficient knowledge to address the impact of high body mass index on reproductive health and promote a healthy lifestyle.
An IT-OT integration concept for flexible process automation
Authors: Azarmipour Mahyar , Hana Ramy , Kleinert Tobias 
Published: May 2023

Abstract
Industry 4.0 is a paradigm that plays a central role in the development of future automation systems. A new generation of industrial automation aims to increase the agility of automation systems. In this context, cooperation with the IT world is an important prerequisite to achieving the requested agility. Therefore, new architectures and solutions have to be developed to realize cooperation between automation and IT systems. The goal of this work is to present for the process industry an architectural design for industrial control systems in order to provide them with a higher level of connectivity and agility.
Towards numerical control of machine tools from the edge cloud
Authors: Susen Christoph , Storms Simon , Brecher Christian 
Published: May 2023

Abstract
A concept has been developed which enables the virtualization and consolidation of NC controllers for machine tools. By decoupling control hardware and software, dynamic scaling of computing power depending on the complexity of the control functions becomes possible. The use of monolithic and over-dimensioned control systems, which are most often not fully exploited but no longer sufficient when new requirements arise, is avoided. Additionally, economic advantages might be exploited by consolidating multiple controllers in an edge cloud. Initial experiments have shown that purely software-based solutions on standard IT hardware are suitable for reliably achieving the required cycle times.
Coming to America: Carnap, Reichenbach and the Great Intellectual Migration. Part II: Hans Reichenbach
Authors: Verhaegh Sander 
Published: May 2023

In the late 1930s, a few years before the start of the Second World War, a small number of European philosophers of science emigrated to the United States, escaping the increasingly perilous situation on the continent. Among the first expatriates were Rudolf Carnap and Hans Reichenbach, arguably the most influential logical empiricists of their time. In this two-part paper, I reconstruct Carnap’s and Reichenbach’s surprisingly numerous interactions with American academics in the decades before their move in order to explain the impact of their arrival in the late 1930s. This second part traces Reichenbach’s development and focuses on his frequent interactions with American academics throughout the 1930s. I show that Reichenbach was quite ignorant about developments in Anglophone philosophy in the first stages of his career but became increasingly focused on the United States from the late 1920s onwards. I reconstruct Reichenbach’s efforts to find a job across the Atlantic and show that some of his English publications—most notably Experience and Prediction—were attempts to change the American narrative about logical empiricism. Whereas U. S. philosophers identified scientific philosophy with the views of the Vienna Circle, Reichenbach aimed to market his probabilistic philosophy of science as a subtler alternative.
The Fate of the Act of Synthesis
Authors: Rump Jacob 
Published: May 2023

I investigate the role of the subject in judgment in Kant, Frege, and Husserl, situating it in the broader and less-often-considered context of their accounts of presentation (Vorstellung) as well as judgment. Contemporary philosophical usage of “representation” tends to elide the question of what Kant called the constitution of content, because of a reluctance, traced to Frege’s anti-psychologism, to attend to subjectivity. But for Kant and Husserl, anti-psychologism allows for synthesis as the subjective act necessary for both “mere presentation” and judgment. In Begriffshrift, Frege alludes to a significant logical role for the subjective act of judgment, and in later work, traces of this logical role remain in the intensional notions of grasping a thought and judging as acknowledging its truth. But Frege’s anti-psychologism blocks interpreting these subjective notions in term of synthesis. Although similar in certain ways to Frege and equally anti-psychologistic, Husserl’s theory of judgment in the Logical Investigations maintains a role for subjective syntheses for presentations and judgments, and goes beyond Kant in allowing for a kind of objectivity at the level of non-judgment presentations. These two great anti-psychologists at the dawn of the parallel heydays of linguistic and phenomenological analysis are thus differentiated by the fates they assign to the act of synthesis.