bluuebunny/crossref_metadata_2025_split huggingface dataset:
Local regulation of striatal dopamine release shifts from predominantly cholinergic in mice to GABAergic in macaques
Authors: Shin Jung Hoon , Goldbach Hannah C , Burke Dennis A , Authement Michael E , Swanson Evan S , Bocarsly Miriam E , Hernandez Sean , Kwon Han B. , Cerveny Sydney E. , Mehr Jacqueline B. , Plotnikova Anya S , Mohanty Arya , Cummins Alexander C. , Pelkey Kenneth A. , McBain Chris J. , Khaliq Zayd M. , Eldridge Mark A.G. , Averbeck Bruno B , Alvarez Veronica A 
Published: January 2025

Dopamine critically regulates neuronal excitability and promotes synaptic plasticity in the striatum, thereby shaping network connectivity and influencing behavior. These functions establish dopamine as a key neuromodulator, whose release properties have been well-studied in rodents but remain understudied in nonhuman primates. This study aims to close this gap by investigating the properties of dopamine release in macaque striatum and comparing/contrasting them to better-characterized mouse striatum, using ex vivo brain slices from male and female animals. Using combined electrochemical techniques and photometry with fluorescent dopamine sensors, we found that evoked dopamine signals have smaller amplitudes in macaques compared to mice. Interestingly, cholinergic-dependent dopamine release, which accounts for two-thirds of evoked dopamine release in mouse slices, is significantly reduced in macaques, providing a potential mechanistic underpinning for the observed species difference. In macaques, only nicotinic receptors with alpha-6 subunits contribute to evoked dopamine release, whereas in mice, both alpha-6 and non-alpha6-containing receptors are involved. We also identified robust potentiation of dopamine release in both species when GABA-A and GABA-B receptors were blocked. This potentiation was stronger in macaques, with an average increase of 50%, compared to 15% in mice. Together, these results suggest that dopamine release in macaque is under stronger GABA-mediated inhibition and that weaker cholinergic-mediated dopamine release may account for the smaller amplitude of evoked dopamine signals in macaque slices.Significance statementDopamine plays a vital role in striatal function, influencing both essential physiological processes and the development of debilitating brain disorders. Most of our current understanding of dopamine release and regulation stems from rodent studies. Investigating the similarities and differences between rodent and primate dopamine systems will improve translatability of findings from rodents to humans. This comparative study identified differences in the local regulation of dopamine release within the striatum of macaques and mice. The modulation by acetylcholine was weaker while the modulation by GABA was stronger in macaques.
Camping Empire
Authors: Borowski Devon J. 
Published: January 2025

In 1781 William Thomas Beckford (1760–1844) inherited a vast colonial fortune built on West Indian sugar and slavery. To mark the occasion, his guardians commissioned a cantata from Venanzio Rauzzini (with words by Girolamo Tonioli) and enlisted the renowned castrati Gasparo Pacchierotti and Giusto Ferdinando Tenducci to perform it. More than a simple panegyric, Il tributo was a thinly veiled attempt at “straightening out” the young man’s perceived effeminacy and his apathy over the business of empire, qualities that were all the more problematic in light of his white West Indian ancestry. The performance of Il tributo, I argue, was a critical moment of social initiation in which cultural norms and structures relating to English masculinity were reinforced and ultimately destabilized.
This article unravels the threads between Beckford’s auditory intimacy with the castrato voice and his tenuous hold on the signifiers of Englishness. It takes Il tributo as the point of departure for exploring voice, race, and empire in late eighteenth-century Britain, imagining Beckford’s experience of listening to Il tributo as a practice of Camp, through which he sought to negotiate his place within the British Empire. “Camp” here refers to the sensibility glossed by Susan Sontag in 1964 as a quality of failed seriousness under extravagant circumstances, though its roots are bound up with eighteenth-century Britain’s global-colonial ambitions. What I term “Camp aurality” was the result of Beckford’s fixation with the castrato voice, or melophilia, and had the power to dethrone the cantata’s moral seriousness. While the performance of Il tributo ultimately failed to enforce imperial proscriptions regarding race and sex, it remains an ambivalent but instructive sonic artifact of the British planter class at the summit of its power.
ЭКОЛОГО-ЦЕНОТИЧЕСКИЕ ОСОБЕННОСТИ ФОРМИРОВАНИЯ ЛЕСНЫХ ЭКОСИСТЕМ В СРЕДНЕМ ТЕЧЕНИИ РЕКИ КОТУЙ В КОНТЕКСТЕ ГЛОБАЛЬНЫХ ИЗМЕНЕНИЙ КЛИМАТА
Authors: КОШКАРОВА В.Л. , КОШКАРОВ А.Д. 
Published: January 2025

В статье освещены результаты палеоботанического изучения торфяных отложений в бассейне среднего течения р. Котуй (Северная Эвенкия). Базовым материалом для исследования стали макроостатки ископаемых растений. На основании изменения видового состава ископаемых объектов и радиоуглеродного датирования по 14С реконструирована динамика фитоценотической структуры лесных формаций за последние 6000 календарных лет. Дана количественная оценка их климатической обусловленности. В начале рассматриваемого времени в результате потепления и повышения влажности увеличивается биоразнообразие растительного покрова и формируется формация бореальных смешанных лесов с елью сибирской ( Picea obovata Ledeb.) и сосной обыкновенной ( Pinus sylvestris L . ). С нарастанием континентальности и похолодания климата биоразнообразие падает, а доминирующей формацией становится редкостойная лиственничная с лиственницей Гмелина ( Larix gmelinii(Rupr.) Rupr.). Установлена динамика границ ареалов лиственницы сибирской ( Larix sibirica Ledeb.), л. Гмелина и кедрового стланика ( Pinus pumila(Pall.) Regel.) на рубеже климатического оптимума и в позднем голоцене.
The article highlights the results of a paleobotanical study of peat deposits in the basin of the middle reaches of the river Kotuy (Northern Evenkia). The macro-remains of fossil plants became the basic material for the study. Based on the change in the species composition of fossil objects and radiocarbon dating by 14C, the dynamics of the phytocenotic structure of changes in the structure of forest formations from 6000 years ago to the present is reconstructed. A quantitative assessment of their climatic conditionality is given. At the beginning of the period under consideration, because of warming and increasing humidity, the biodiversity of the vegetation cover increases and the formation of mixed forests (Siberian spruce ( Picea obovata Ledeb.), Scots pine ( Pinus sylvestris L.)) is formed. With an increase in the continentality of the climate and cooling, biodiversity decreases, and the sparse larch (Gmelin larch ( Larix gmelinii (Rupr.) Rupr.))becomes the dominant formation. The dynamics of the boundaries of the ranges of Siberian larch ( Larix sibirica Ledeb.), Gmelin larch, Siberian dwarf pine ( Pinus pumila (Pall.) Regel.) at the boundary of the climatic optimum and in the late Holocene was established.
ЯСЕНЕВАЯ ИЗУМРУДНАЯ УЗКОТЕЛАЯ ЗЛАТКА AGRILUS PLANIPENNIS FAIRMAIRE (COLEOPTERA: BUPRESTIDAE) НА АЛТАЕ (ЮЖНАЯ СИБИРЬ)
Authors: БАРАНЧИКОВ Ю.Н. , БАБИЧЕВ Н.С. , СПЕРАНСКАЯ Н.Ю. , ДЕМИДКО Д.А. , ВОЛКОВИЧ М.Г. , СНИГИРЕВА Л.С. , АКУЛОВ Е.Н. , КИРИЧЕНКО Н.И. 
Published: January 2025

Ясеневая изумрудная узкотелая златка ( Agrilus planipennis Fairmaire (Coleoptera: Buprestidae)) - агрессивный восточноазиатский инвайдер, уничтоживший миллионы ясеней ( Fraxinus L.) в Северной Америке и в Восточной Европе. Ученых и практиков волнует продвижение вида на запад, в Центральную Европу. Оказалось, что климатические условия и наличие кормового растения - ясеня пенсильванского ( Fraxinus pennsylvanica Marshall) - делают возможным существование A. planipennis и на юге Сибири. В 2024 г. вредитель был обнаружен в г. Барнауле - административном центре Алтайского края. К августу златка уничтожила почти треть посадок ясеня в городе, и к категории здоровых в настоящее время можно отнести лишь 8 % деревьев. Судя по соотношению возрастов личинок, вид развивается в Барнауле по двухлетней генерации. Паразитированных личинок златки в Барнауле обнаружить не удалось. Это свидетельствует о том, что основной фактор ее контроля в Европе - браконид Spathius polonicus Niezabitowski- либо еще не достиг Сибири, либо пока не поднял численность до необходимого уровня. Подчеркивается перспективность интродукции во вторичный ареал златки восточноазиатского паразитоида Spahius galinae Belokobylskij et Strazanac- эффективного агента биоконтроля A. planipennis- и устойчивого к златке ясеня маньчжурского ( F. mandshurica Rupr.).
Emerald ash borer ( Agrilus planipennis Fairmaire (Coleoptera: Buprestidae)) is an aggressive East Asian invader that has destroyed millions of ash ( Fraxinus L.) trees in North America and Eastern Europe. Researches and practitioners are concerned about ongoing westward distribution of the species into Central Europe. In addition to that, the invasion of this buprestid to Siberia is also not ruled out bearing in mind suitable climatic conditions, particularly on the south, and the presence its favorable host plant, the green ash ( Fraxinus pennsylvanica Marshall). In 2024, the pest has been detected in Barnaul, the administrative center of Altai Krai. By August, the beetle destroyed almost 30 % of ash trees in the city and only 8 % of trees looked healthy. Based on the ratio of larval instars, the pest develops two years per generation in Barnaul. No parasitized larvae of A. planipennis was documented in Barnaul suggesting that the parasitoid, the braconid Spathius polonicus Niezabitowski, which controls this buprestid in Europe, either has not yet appeared in Siberia or remains at a low, undetectable, density. The prospects of introduction of the East Asian parasitoid Spahius galinae Belokobylskij et Strazanac (the most effective biocontrol agent of A. planipennis at its primary range) and the Manchurian ash ( F. mandshurica Rupr.) (the resistant host) to the secondary pest range are emphasized.
Byzantine Illyricum in the 7th–9th centuries
Authors: Komatina Predrag 
Published: January 2025

AbstractThe paper discusses the issue of Byzantine presence in the territory of the prefecture of Illyricum in the Balkan interior after the Slavic-Avar invasion in the early seventh century. It is argued that the Slavic settlement of the Balkan Peninsula was not as thorough as usually assumed, but that there were in the Balkan interior, amidst its general depopulation, sporadic remains of the provincial Roman population of urban culture during the seventh to ninth centuries with certain degree of Byzantine political authority until the Bulgarian conquest in the early ninth century.
Analysis of the distribution of gas turbine unit operation modes as a tool for improving the stability of the power system
Authors: Yavorskyi Oleksandr , Tarakhtii Olha , Zhukovskyi Vladyslav , Panin Viktor 
Published: January 2025

The object of research is the optimal distribution of operating modes of gas turbine units (GTU) as a tool for increasing the stability of the Ukrainian power system in crisis situations. Given the challenges caused by the destruction of the energy infrastructure due to massive shelling, ensuring the stability of electricity supply requires the development of new approaches to frequency regulation. The frequency of electricity is a critical parameter that determines the balance between generation and consumption. Its violation can cause serious consequences, such as equipment shutdown and destabilization of the power system.
The work was aimed at creating mathematical models of GTU and the power system, allowing to analyze the change in frequency and power depending on the operating modes. As well as at developing a methodology for optimal load distribution between units under conditions of variable external influences. The work describes in detail the structure of the GTU model in the Simulink environment, which takes into account dynamic processes in gas volumes, the combustion chamber and the rotor of the unit. The proposed methodology is based on the study of two approaches to power distribution: uniform and proportional to the control range of each GTU. A numerical experiment has shown that uniform distribution is better suited for positive disturbances, reducing the integral indicator (integral square error ISE) by 15 % compared to traditional methods, while for negative disturbances, proportional distribution demonstrates a decrease in ISE by 20 %. In the case of positive disturbances, uniform distribution for different combinations of capacities on average shows 0.6 % better control quality than the proportional approach, and for negative disturbances, proportional distribution on average shows 0.25 % better control quality, compared to uniform.
The research results have significant practical potential and can be used to improve the control systems of the power systems of Ukraine in conditions of a shortage of generating capacities and crisis situations.
The effectivity of pandanus leaf extract for the treatment of sangkuriang catfish juvenile Clarias gariepinus infected by Aeromonas hydrophila
Authors: Sopiah Siti , Rosidah Rosidah , Lili Walim , Iskandar Iskandar , Suryadi Ibnu Bangkit 
Published: January 2025

ABSTRACTThe aim of this study was to determine the effective concentration of pandanus Pandanus amaryllifolius leaf extract for the treatment of sangkuriang catfish juvenile infected by Aeromonas hydrophila. The method used in this study was an experimental method with completely randomized design consisted of five treatments and three replications. The treatments were A (control), B (400 mg/L), C (600 mg/L), D (800 mg/L), and E (1000 mg/L) trough immersion for 24 hours through immersion for 24 hours. The fish has infected with A. hydrophila bacteria as much as 20 mL of NaCl/L in 10 L of water medium with a density of 108 CFU/mL through immersion. The observed parameters were clinical symptoms, recovery process, survival rate, and water quality. The results showed that pandanus leaf extract at a concentration of 800 mg/L for 24 hours was effective for treating sangkuriang catfish juvenile that infected by A. hydrophila with a survival rate of 86.67%. Based on the regression analysis, it discovered that the optimum concentration of pandanus leaf extract through immersion for 24 hours was 774.39 mg/L and the predicted survival was 92.16%. Keywords: Aeromonas hydrophila, catfish fingerlings, effective concentration, infection, pandanus leaf extract ABSTRAKPenelitian ini bertujuan untuk menentukan konsentrasi yang efektif dari ekstrak daun pandan wangi Pandanus amaryllifolius untuk pengobatan benih lele sangkuriang Clarias gariepinus yang terinfeksi bakteri A. hydrophila. Metode yang digunakan dalam penelitian ini adalah metode eksperimental rancangan acak lengkap dengan lima perlakuan dan tiga ulangan. Perlakuan penelitian adalah A (kontrol), B (400 mg/L), C (600 mg/L), D (800 mg/L), dan E (1000 mg/L). Ikan uji diinfeksi bakteri A. hydrophila sebanyak 20 mL NaCl/L dalam 10 L media air dengan kepadatan 108 CFU/mL melalui perendaman selama 24 jam. Parameter yang diamati meliputi gejala klinis, waktu pulih, kelangsungan hidup, dan kualitas air. Hasil penelitian menunjukkan bahwa penggunaan ekstrak daun pandan wangi pada konsentrasi 800 mg/L selama 24 jam efektif untuk pengobatan benih lele sangkuriang yang terinfeksi bakteri A. hydrophila dengan tingkat kelangsungan hidup sebesar 86,67%. Berdasarkan analisis regresi diketahui bahwa konsentrasi optimum penggunaan ekstrak daun pandan wangi melalui perendaman selama 24 jam yaitu 774,39 mg/L dan prediksi kelangsungan hidup ikan adalah 92,16%. Kata kunci : Aeromonas hydrophila, benih lele sangkuriang, ekstrak daun pandan, infeksi, efektifitas konsentrasi
The application value of preoperative F-FDG PET/CT in preoperative localized clear cell renal cell carcinoma
Authors: Betsunoh Hironori , Takada-Owada Atsuko , Sakamoto Setsu , Yuki Hideo , Nukui Akinori , Hayashi Keitaro , Yoshihiro Nakagami , lshida Kazuyuki , Kamai Takako 
Published: January 2025

Aim: In cancer tissues, glycolysis metabolism is often heightened, making 18F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) useful for assessing glucose metabolism. However, the kidneys' high glucose metabolism makes it difficult to distinguish between normal renal tissue and renal cancer. This study aims to evaluate the maximum standardized uptake value (SUVmax) in renal cancer using PET/CT and determine its relationship to prognosis.
Methods: We also aim to examine the correlation between SUVmax and clinical parameters and its potential link to prognosis. We enrolled 105 patients who underwent FDG-PET/CT between March 2012 and October 2017. These patients, diagnosed with localized renal cell carcinoma (RCC), underwent surgery and were pathologically confirmed to have clear cell RCC (ccRCC). We investigated the impact of SUVmax and other parameters on recurrence.
Results: SUVmax and C-reactive protein (CRP) were associated with tumor progression, alongside stage, nuclear grade, microvascular invasion [v(+)], and tumor-infiltrating lymphocytes (TILs). Multivariate analysis with recurrence-free survival (RFS) as the endpoint indicated significant results (SUVmax ≥ 3.7: relative risk 8.98, P < 0.01; CRP ≥ 0.11 mg/dL: relative risk 6.03, P < 0.01, n = 89). In survival curve analysis with RFS, high SUVmax or elevated CRP predicted poor prognosis, with further worsening when v(+) was added.
Conclusion: SUVmax is a strong prognostic factor for poor outcomes. CRP is also a prognostic factor, though it should be interpreted cautiously, as CRP reflects overall systemic conditions and may not exclusively represent renal cancer activity. Further research into pre-treatment RCC prognosis prediction is anticipated.
FAUNA AND SEDIMENTS AS ARCHIVES OF LATE HOLOCENE ENVIRONMENTAL CHANGE (RASDHOO ATOLL LAGOON, MALDIVES, INDIAN OCEAN)
Authors: Diers Diana , Reineke Annika , Walkenfort Daniel , Humblet Marc , Łukowiak Magdalena , Gischler Eberhard 
Published: January 2025

Abstract
Coral reef habitats are changing due to both natural and anthropogenic influences operating at different scales. To better understand and differentiate between these processes, it is important to reconstruct natural variability in reef communities. Here, we examine late Holocene sediments (0–4 kyrs BP) along three vibracores from marginal and central locations, and adjacent to a patch reef, in the lagoon of Rasdhoo Atoll, Maldives. Sediment analysis included quantification of corals, echinoids, and sponges, as well as changes in texture. In addition, growth forms and degree of encrustation of coral fragments were documented. The aim of this study is to identify fluctuations in the proportion of organism remains and sediment composition and possible patterns over time in response to environmental changes. The sediment compositions in the three cores are substantially different. Fragments of reef corals (including Acropora spp., Seriatopora hystrix) were found preferentially in two cores adjacent to reef structures and channels through the atoll rim, suggesting sediment redeposition due to enhanced water circulation compared to the deeper lagoon location. Fragments of echinoids belonging to Echinometra sp., Diadema sp. and Cidaridae, mainly decreased in abundance over time. Different trends in organism proportion in the three cores can be attributed to local changes in ecological interactions among organisms, lagoonal circulation influenced by patch-reef growth and sand-spit development, and regional sedimentological events including tsunamis. Global changes in temperature, El-Niño frequency, and sea level fluctuations did not leave clear imprints in the lagoonal record. This study highlights that organism remains from atoll lagoons have great potential as archives of local to regional ecological and environmental change, as they store information on faunal composition, long-term geomorphological change, and short-term events and should therefore receive more attention in future investigations.
Olfactory Tubercle mediates adaptive social behavior through distinct control of threat assessment and memory updating.
Authors: Bellone Camilla , Casarotto Giulia , Jourdain Lorena , Gemelli Anastasia 
Published: January 2025

Abstract

The ability to dynamically assess and update threat responses based on changing environmental contexts is fundamental for survival. Here, we developed a novel odor-based paradigm to investigate the neural mechanisms underlying social threat processing, where mice first encountered a non-threatening conspecific that subsequently became aggressive. This paradigm allowed us to study how mice assess the threat and update their memories when re-exposed to the aggressor in a non-threatening context. Using a combination of in vivo calcium imaging, chemogenetics, and electrophysiology, we identified the olfactory tubercle (OT) as a key region mediating social threat assessment. While OT activity was not required during the initial aggressive encounter, it proved to be essential during recall, where its inhibition prevented both the expression of avoidance behavior and subsequent memory updating. Importantly, we found that recall induced pathway-specific synaptic plasticity at the basolateral amygdala (BLA) to OT synapses. This plasticity persisted even after behavioral extinction, suggesting a neural substrate for maintaining specific social memories while allowing behavioral flexibility. Given this persistent plasticity, we finally investigated the mechanisms driving avoidance behavior during threat assessment. We found that serotonin release in the OT during recall facilitated avoidance behavior, while its blockade triggered dopamine release and promoted approach behavior, revealing a novel neuromodulatory switch controlling social behavior. Our findings reveal how the OT, through precise neuromodulatory control and synaptic plasticity, orchestrates the dynamic updating of social memories essential for adaptive behavior.
Development of the false alarm filtering method for GEO-KOMPSAT-2A wildfire detection product
Authors: CHAE Seoyoung , Choi Yong-Sang , Choi Hwayon 
Published: January 2025

Abstract

Wildfires have caused significant damage to the economy, human health, and ecosystems over extended periods. Satellites offer advantages as wildfire detection tools because they provide near real-time, continuous observations in areas that are difficult to manage directly by humans. But in previous studies, satellite active wildfire detection products were prone to generating false alarms in areas with high reflectance, such as bare soils, urban regions, water bodies, and clouds. This issue arises because infrared channels were used for wildfire detection, but their observations include both solar and thermal radiances. In this study, we apply a calculation, based on a previous study, to wildfire detection that reduces solar reflectance radiance and propose a filtering method to eliminate false alarms occurring in cloud edge areas. South Korea, where detailed annual wildfire information is available, was selected as the study area to develop a region-specific false alarm filtering algorithm for wildfire detection product. The filtering algorithm was compared to the GEO-KOMPSAT-2A operational product using data from 62 wildfire cases that occurred in 2022. As a result, the number of false alarms was significantly reduced from 896 to 25, the False alarm ratio (FAR) decrease from 96.34–47.17% and the Probability of Detection (POD) showed a slight decrease from 53.23–45.16%. The results of this study are expected to contribute to more efficient disaster and risk management by enabling more accurate wildfire detection.