bluuebunny/crossref_metadata_2025_split huggingface dataset:
Treatment of Vertebral Compression Fractures with preoperative Lumbar support pad reduction: 19 cases and a literature Review of Physically Assisted Therapy
Authors: He Wei , He Da , Liao Tao , Feng Jingyun , Liu Mingming , Zha Xiluobu 
Published: April 2023

Abstract

BackgroundVertebral Compression Fractures and dislocation is usually treated by posterior open reduction nail or internal fixation system, but the high altitude lumbar surgery carries great risks. When the collapse of the vertebra fails to return to the normal height, kyphosis will occur in the later stage of the spine. For the patients with thoracolumbar vertebral compression fracture with pyramidal collapse, preoperative reduction of lumbar support pad was adopted, and good clinical results were obtained.Case presentation:According to the strict screening criteria, 19 patients with thoracolumbar compressibility fracture who will be treated in our hospital in 2021 were selected. All the selected patients were confirmed by imaging examination and the cone front height of compression fracture was measured before surgery. All patients received preoperative reduction treatment with lumbar support pads, and were reexamined after the treatment. The results showed that all patients had significant recovery in their lumbar spine, with VAS scores and activity function scores significantly superior to those before the treatment (p < 0.05). The height between vertebrae in all patients returned to the normal range, with 67.3% of patients having the best pyramidal recovery.Clinical discussion:The plateau has high altitude, low atmospheric pressure, and low oxygen content. It is extremely difficult to perform surgery on thoracic and lumbar vertebral compression fractures at high altitude. Preoperative adjuvant treatment is usually required to alleviate the condition, and then the patient is transferred to a low altitude area for surgery. In this study, lumbar support pads were used as an adjunct treatment to significantly improve the lumbar spine.ConclusionPreoperative reduction of lumbar support pad can effectively relieve the pain of patients with thoracolumbar compressibility fracture, effectively restore the height of compressed vertebral body before surgery, and effectively improve the patients' limited mobility. This treatment method is worth promoting in plateau medical institutions.
The gestational weight gain trajectories of full-term singleton pregnant women for different neonatal birth weight outcomes in Zhongshan, China: a multi-center retrospective longitudinal follow-up study
Authors: Li Bing , chen Ang 
Published: April 2023

Abstract

Background Low or excess gestational weight gain (GWG) is associated with higher risk of adverse maternal and infant outcomes, and the GWG charts were different in four pre-pregnancy BMI categories, but the GWG trajectories based on different pregnant outcomes were seldom established to date.Objectives To establish a maternal GWG trajectory for each neonatal birth weight category by pre-pregnancy BMI, and analyse their associations.Methods A retrospective longitudinal follow-up study was conducted base on the real-word electronic healthcare record of prenatal visit and delivery in 28 hospitals, which included 319,926 pregnant women between January 2017 and December 2020 in Zhongshan, China. The means and percentiles of GWG by gestational week (GW) for each neonatal birth weight category were calculated and fitted by GAMLSS, and were used to establish GWG trajectories respectively.Results There were 100,691 and 136,342 full-term singleton pregnancies in final two cohorts respectively. After 15th GW to 40th GW, low birth weight (LBW) or small for gestational age (SGA) had a lower level and macrosomia or large for gestational age (LGA) had a higher level of mean GWG comparing with normal birth weight (NBW) or appropriate gestational age (AGA) (P < 0.05) at each GW. The mean and percentile charts of GWG showed that the GWG trajectories were lower in LBW/SGA and higher in macrosomia/LGA than in NBW/AGA.Conclusions Neonatal birth weight outcomes are associated with the distinctive maternal GWG trajectories, and neonatal health outcomes depend on sustenance of an appropriate GWG trajectory.
Identification of PCB Congeners and their Thresholds associated with Diabetes using Decision Tree Analysis
Authors: Lan Tuo , Liu Buyun , Bao Wei , Thorne Peter S. 
Published: May 2023

Abstract
Few studies have investigated the potential combined effects of multiple PCB congeners on diabetes. To address this gap, we used data from 1244 adults in the National Health and Nutrition Examination Survey (NHANES) 2003–2004. We used 1) classification trees to identify serum PCB congeners and their thresholds associated with diabetes; and 2) logistic regression to estimate the odds ratios (ORs) and 95% confidence intervals (CIs) of diabetes with combined PCB congeners. Of the 40 PCB congeners examined, PCB 126 has the strongest association with diabetes. The adjusted OR of diabetes comparing PCB 126 > 0.025 to ≤ 0.025 ng/g was 2.14 (95% CI 1.30–3.53). In the subpopulation with PCB 126 > 0.025 ng/g, a lower PCB 101 concentration was associated with an increased risk of diabetes (comparing PCB 101 < 0.72 to ≥ 0.72 ng/g, OR = 3.3, 95% CI: 1.27–8.55). In the subpopulation with PCB 126 > 0.025&PCB 101 < 0.72 ng/g, a higher PCB 49 concentration was associated with an increased risk of diabetes (comparing PCB 49 > 0.65 to ≤ 0.65 ng/g, OR = 2.79, 95% CI: 1.06–7.35). This nationally representative study provided new insights into the combined associations of PCBs with diabetes.
Variable-Order Conformable Fractional Derivatives using 2-stage Runge-Kutta and Euler Methods
Authors: Mishra S. R. , Mohapatra S.N. , Jena P. 
Published: April 2023

Abstract

The present investigation is intended to the implementation of new numerical approaches for the variable-order conformable fractional derivatives that override the fact of earlier constant order fractional derivatives. The generalized conformable variable-order Taylor’s theorem is deployed to extract two new techniques such as conformable variable order 2-stage Runge-Kutta and conformable variable order Euler methods. Further, these numerical techniques are employed by considering various fractional variables as well as constant order derivatives. However, the main attraction of these two methodologies is also applicable to fractional financial model and comparison of these methodologies with classical derivatives, and the numerical results are appended in tabular form as well as graphically.
The Epidemiology of Types of Ocular Trauma in A Tertiary Center in North of Iran
Authors: Alizadeh Yousef , Sardabchahi Ghazaleh Mohammadi Manesh , Medghalchi Abdolreza , Behboudi Hassan , Soltani-Moghadam Reza , Akbari Mitra , Azaripour Ebrahim , Poursayed Seyedeh Zahra , Nabavi seyed Amin , Kianmehr Shila , Alizadeh halleh , Dourandeesh Maryam Dourandeesh , Leyli Ehsan Kazemnejad , Pourdeilami Narges 
Published: May 2023

Abstract

PurposeTo investigate the epidemiology of types of ocular trauma in a tertiary center in north of Iran.MethodsThis cross-sectional study was carried out on 476 patients with ocular trauma referred to emergency eye department of Amir-Almomenin Hospital in 2021. Personal information and types of traumas collected by medical records and a designed questionary. Data were collected and analyzed using IBM SPSS 26. Descriptive statistics were used to determine the frequency and distribution of traumas.ResultsThe most vulnerable groups were 31–40 years (28.8%) and mean age of 41.5 ± 17.4. Most of the injuries occurred at home (57.1%) and few of them used eyewear (5.3%). Patients were mostly lived in city. Closed globe injuries were the prominent types of traumas at about (96%) and Open close injuries were at a low rate (4%).ConclusionOcular Trauma is a common cause of trauma in north of Iran. Closed globe injuries were the most common types of traumas occurred between the age of 30–40 and male were most commonly susceptible
A Nude Mutant Derived from Five Decades-Old Rat Colony with an Immuno-potent Character - A Potential Model for Non-Communicable Diseases.
Authors: Satyavani M. , Patil Pradeep B. , Naik R. Ravindar , Srin M. , Qadri SSYH 
Published: April 2023

Abstract

Background: A spontaneous mutant rat with a hairless phenotype and an intact thymus was discovered in a long-standing SD/NIN rat colony at a national animal resource facility.
Objective: We conducted extensive phenotypic and biochemical analyses on this mutant strain to determine its suitability as a preclinical model for immunocompetent testing in non-communicable disease research.
Methodology: To accomplish this objective, we subjected the mutant rats to strict and frequent phenotypic and genetic surveillance. We assessed their food intake, body weight, blood cell profile, clinical chemistry, adipose tissue deposition, and bone mineral density using TOBEC and DXA analysis.
Results: Initially, only two hairless mutant rats, a male and a female, were born from a single dam in the SD/NIN rat strain. However, the results indicates that the mutant colony propagated from these unique pups displayed distinct phenotypic features and exhibited differences in feeding behaviour, weight gain, and clinical biochemistry. The food conversion rate (FCR) was significantly higher in nude females (2.8-fold) while 26% lower in nude males. Both sexes of nude rats had significantly higher triglycerides and lower glucose levels in females. However, glucose levels did not change in male nude rats. Furthermore, nude female and male rats had significantly lower fat (TOBEC) and bone mineral content (DXA). Nonetheless, bone mineral density was only slightly lower (7-8%) compared to the heterozygous groups.
Conclusion: These findings indicate that the spontaneous mutant rat has the potential to serve as an immuno-potent and modulatory testing system in PK/PD and toxicology, which can be further explored for therapeutic drug discovery.
Neural network-aided milk somatic cell count gain prediction
Authors: Nagy Sára Ágnes , Csabai István , Varga Tamás , Póth-Szebenyi Bettina , Gábor György , Solymosi Norbert 
Published: April 2023

Abstract

Sub-clinical mastitis (SM) is the most economically damaging yet often visually undetectable disease of dairy cows. Early detection and treatment can reduce the loss caused by the disease, thus, the continuous improvement of SM diagnostic methods is necessary. Albeit, the somatic cell count (SCC) of milk is commonly measured for diagnostic purposes, its direct determination is not widely used in everyday practice. The primary objective of our work was to investigate whether the predictive value of SM diagnostics can be improved by training artificial neural networks (ANNs) on data generated using common milking machines. The best ANN classifier had a sensitivity of 0.54 and a specificity of 0.77, which is comparable to the performance of several California Mastitis Tests (CMT) in the literature. Combining two diagnostic tests, ANN and CMT, we concluded that the positive predictive value could be up to 50% higher than the value provided by the individual CMT. While the implementation of CMT is a labor-intensive process, in milking parlors where milk or milk yield data can be measured automatically, similar to our work, SCC-gain predictions for all individuals could be obtained on a daily basis.
Design of polymeric thin films with nanovolcanoes for trapping hydroxyapatite nanoparticles to promote or inhibit cell proliferation
Authors: Łojkowski Maciej , Walejewska Ewa , Sosnowska Malwina , Opalińska Agnieszka , Grubczak Kamil , Jaworski Sławomir , Moniuszko Marcin , Swieszkowski Wojciech 
Published: May 2023

Abstract
Arrays of nanoscale cavities in the form of nanovolcanoes can act as traps for nanoparticles to obtain surfaces with the desired functionality. The nanoparticle trapping strategy is based on generating negative pressure inside the nanocavities and aspiration of nanoparticles from the suspension. A new approach has been proposed to prepare polymeric nanocavities and tune their geometry to increase trapping efficiency. The strategy uses microphase separation in a polymer blend and tuning the shape of polymer islands to use them as molds for nanovolcanoes by tuning the molecular weight distribution of the island phase. Tuning the silhouette of the nanovolcanoes made it possible to find a geometry that allows air storage. Hydroxyapatite nanoparticles were entrapped in the nanovolcanoes to show that cells will proliferate in the presence of nanovolcanoes with hydroxyapatite, while nanovolcanoes without hydroxyapatite will block proliferation.
Unmanned aerial vehicles for planning rooftop rainwater harvesting systems: a case study from Gurgaon, India
Authors: Puppala Harish , Peddinti Pranav R. T. , Kim Byungmin , Arora Manoj Kumar 
Published: April 2023

Abstract

Rooftop rainwater harvesting systems (RRWHS) effectively provide water access by storing precipitated water. The amount of water harvestable using these systems is proportional to the availability of rooftop areas in the region. The use of satellite imagery has gained traction in recent times considering the challenges in conducting a manual survey to determine the rooftop area. However, the limitations on spatial resolution impaired stakeholders from conducting similar assessments in areas with small residential units. In this regard, the use of unmanned aerial vehicles (UAVs) providing high-resolution spatial imagery for the delineation of rooftops of all scales has become popular. The present study is an attempt to utilize UAV-generated orthomosaics to estimate the harvestable quantity of rainwater for setting up an RRWHS. A study area in the Gurgaon district, India, is selected, and the steps involved in estimating the quantity of water harvestable using UAVs are demonstrated. In addition to these computations, a suitable site for constructing the storage unit is identified with the aid of a weighted overlay technique implemented using a Geographic Information System. The results from the study show that nearly 11,229 m3 of water can be harvested per year in the study site using the RRWHS.
Evaluation on real-time self-organization algorithm of forest cultivation, tea planting and tea processing for sustainable ecosystem management of agricultural water resources
Authors: Wang Zhenhong , Zhang Liyong , Song Minfeng , Luobu Sangjie , Jiu Mei , Dan Zhen , Peng Hong 
Published: April 2023

Abstract
Agricultural water resources are water resources that can be used for agricultural production, including surface water, groundwater and soil water. The sustainable use of water resources is of great significance to agriculture and rural economy. In the context of climate change and the increasing crisis of water resources, how to effectively use forest resources and other natural resources to achieve sustainable management of agricultural water ecosystems has become an increasingly urgent issue. Therefore, this paper proposed a real-time self-organization algorithm for forest cultivation, tea planting and tea processing for sustainable ecosystem management of agricultural water resources. This paper first described the sustainable ecosystem of agricultural water resources, carried out optimization analysis on tea planting and processing technology, using the genetic optimization algorithm based on decision tree and then carried out an experimental analysis on a tea garden. It can be seen from the data that the average monthly temperature of the tea garden cultivated by the algorithm in this paper was between 13.4 and 20.5 °C and the average annual temperature was 16.16 °C. However, the average monthly temperature of the traditional cultivation method was between 11.5 and 16.8 °C and the average annual temperature was 13.64 °C.
Cr(VI) anion-imprinted polymer synthesized on mesoporous silicon via synergistic action of bifunctional monomers for precise identification and separation of Cr(VI) from aqueous solution by fixed-bed adsorption
Authors: Su Ya , Kang Yumeng , Huang Qinya , Zhang Jiahao , Liu Jinhua , Hu Zhaoyong , Liu Zhanchao , Liu Yan 
Published: April 2023

Abstract

The novel Cr(VI) anion-imprinted polymer (Cr(VI)-IIP) was prepared by a surface imprinting technique with bifunctional monomers pre-assembly system based on mesoporous silicon (SBA-15). The synthesized Cr(VI)-IIP was characterized by Fourier transmission infrared spectra (FT-IR), energy dispersive spectrometer (EDS), scanning electron microscope (SEM), transmission electron microscope (TEM), X-ray powder diffractometer, N2 adsorption–desorption and thermogravimetric analysis (TGA), proving to be with a highly ordered mesoporous structure, as well as favorable thermal stability. The saturated adsorption amount was 96.32 mg/g, which was 2.7 times higher than that of non-imprinted polymer (NIP). Kinetic experiments showed that the adsorption equilibrium state was obtained within 70 min. In addition, in the selectivity experiments, Cr(VI)-IIP exhibited strong specific recognition ability for Cr(VI) and could realize the separation of Cr(VI) and Cr(III) from an aqueous solution. The dynamic adsorption experiments exhibited that the dynamic adsorption efficiency of Cr(VI)-IIP was as high as 71.57%. Meanwhile, the dynamic regeneration experiments showed that the adsorption amount of Cr(VI)-IIP did not decrease significantly after repeating for five times. All of the findings suggested that Cr(VI)-IIP could achieve precise identification as well as efficient separation of Cr(VI) from aqueous solution.
Chemical Strategies towards the Development of Effective Anticancer
Peptides
Authors: Li Cuicui , Jin Kang 
Published: April 2023

Abstract:
Cancer is increasingly recognized as one of the primary causes of death and
has become a multifaceted global health issue. Modern medical science has made significant
advancements in the diagnosis and therapy of cancer over the past decade. The detrimental
side effects, lack of efficacy, and multidrug resistance of conventional cancer therapies
have created an urgent need for novel anticancer therapeutics or treatments with
low cytotoxicity and drug resistance. The pharmaceutical groups have recognized the crucial
role that peptide therapeutic agents can play in addressing unsatisfied healthcare demands
and how these become great supplements or even preferable alternatives to biological
therapies and small molecules. Anticancer peptides, as a vibrant therapeutic strategy
against various cancer cells, have demonstrated incredible anticancer potential due to
high specificity and selectivity, low toxicity, and the ability to target the surface of traditional
“undruggable” proteins. This review will provide the research progression of anticancer
peptides, mainly focusing on the discovery and modifications along with the optimization
and application of these peptides in clinical practice.
Nobiletin in Cancer Therapy; Mechanisms and Therapy Perspectives
Authors: Moazamiyanfar Reza , Rezaei Sepideh , AliAshrafzadeh Hasan , Rastegar-Pouyani Nima , Jafarzadeh Emad , Mouludi Kave , Khodamoradi Ehsan , Zhaleh Mohsen , Taeb Shahram , Najafi Masoud 
Published: April 2023

Abstract:
Cancer has remained to be one of the major challenges in medicine and regarded as the second leading
cause of death worldwide. Different types of cancer may resist anti-cancer drugs following certain mutations
such as those in tumor suppressor genes, exhaustion of the immune system, and overexpression of drug
resistance mediators, which increase the required concentration of anticancer drugs so as to overcome drug resistance.
Moreover, treatment with a high dose of such drugs is highly associated with severe normal tissue toxicity.
Administration of low-toxic agents has long been an intriguing idea to enhance tumor suppression. Naturally
occurring agents e.g., herb-derived molecules have shown a dual effect on normal and malignant cells. On
the one hand, these agents may induce cell death in malignant cells, while on the other hand reduce normal cell
toxicity. Nobiletin, one of the well-known polymethoxyflavones (PMFs), has reportedly shown various beneficial
effects on the suppression of cancer and the protection of normal cells against different toxic agents. Our
review aims to explain the main mechanisms underlying nobiletin as an inhibitor of cancer. We have reviewed
the mechanisms of cancer cell death caused by nobiletin, such as stimulation of reactive oxygen species (ROS),
modulation of immune evasion mechanisms, targeting tumor suppressor genes, and modulation of epigenetic
modulators, among others; the inhibitory mechanisms of nobiletin affecting tumor resistance properties such as
modulation of hypoxia, multidrug resistance, angiogenesis, epithelial-mesenchymal transition (EMT) have been
fully investigated. Also, the inhibition of anti-apoptotic and invasive mechanisms induced by nobiletin will later
be discussed. In the end, protective mechanisms of nobiletin on normal cells/tissue, clinical trial results, and future
perspectives are reviewed.
Psidium guajava: An Insight into Ethnomedicinal Uses, Phytochemistry, and Pharmacology
Authors: Chechani Bhawna , Roat Priyanka , Hada Sonal , Yadav Dinesh Kumar , Kumari Neetu 
Published: April 2023

Background:
Psidium guajava (guava) is widely distributed in tropical and subtropical
regions and adapted to various environmental conditions. Guava is an important economic fruit
widely used as food and folk medicine. It contains flavonoids, alkaloids, tannins, triterpenoids, reducing
sugars, essential oils, carotenoids, polyphenols, etc. The presence of triterpenoid acids such
as guavacoumaric, ursolic, jacoumaric, guajavanoic, guavenoic, and Asiatic acids helps to develop
novel drugs against various diseases. It is used traditionally for medicinal purposes, mainly for antioxidant,
antimicrobial, antispasmodic, antidiabetic, anticancer, antiallergy, anti-inflammatory,
and hepato-protective properties.

Objective:
The systematic literature study aims to summarize its botanical description, phytochemicals,
pharmacological activities, and clinical trials. This review focuses on the plant’s chemical
composition and scientific approaches to human welfare.

Methods:
A systematic literature search was done on Psidium guajava through previous literature
and online databases such as Google Scholar, Pubmed, Science Direct, etc., to explain its ethnomedicinal
uses, phytochemistry, and pharmacological applications.

Results:
Previous literature studies of Psidium guajava suggest it can serve as antioxidant, antimicrobial,
antispasmodic, antidiabetic, anticancer, anti-allergy, anti-inflammatory, and hepatoprotective
effects. Successful clinical trials performed on the plant extracts against infantile rotaviral
enteritis and infectious gastroenteritis showed future directions to work with the plant for clinical
applications.

Conclusion:
In this review, an attempt is made to show all literature studied, especially in phytochemistry,
pharmacology, clinical trials and uses as traditional folk medicine around the world.
The leaves have been used by folklore over the years to treat various ailments such as skin ulcers,
diarrhoea, vaginal irritation, cough, conjunctivitis, etc. Further studies are required to explore more
therapeutic remedies and to develop new medicines for future perspectives.