bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adverse cardiac remodeling is absent in patients with true controlled resistant hypertension
Authors: Matanes Faris , Siddiqui Mohammed , Velasco Alejandro , Sharifov Oleg , Kreps Eric , Dudenbostel Tanja , Judd Eric K , Zhang Bin , Lloyd Steven G , Oparil Suzanne , Calhoun David A 
Published: April 2023

AbstractResistant hypertension (RHTN), defined as blood pressure (BP) that is uncontrolled with ≥3 medications, including a long‐acting thiazide diuretic, also includes a subset with BP that is controlled with ≥4 medications, so‐called controlled RHTN. This resistance is attributed to intravascular volume excess. Patients with RHTN overall have a higher prevalence of left ventricular hypertrophy (LVH) and diastolic dysfunction compared to patients with non‐RHTN. We tested the hypothesis that patients with controlled RHTN due to the intravascular volume excess have higher left ventricular mass index (LVMI), higher prevalence of LVH, larger intracardiac volumes, and more diastolic dysfunction compared to patients with controlled non‐resistant hypertension (CHTN), defined as BP controlled with ≤3 anti‐hypertensive medications. Patients with controlled RHTN (n = 69) or CHTN (n = 63) who were treated at the University of Alabama at Birmingham were offered enrollment and underwent cardiac magnetic resonance imaging. Diastolic function was assessed by peak filling rate, time needed in diastole to recover 80% of stroke volume, E:A ratios and left atrial volume. LVMI was higher in patients with controlled RHTN (64.4 ± 22.5 vs 56.9 ± 11.5; P = .017). Intracardiac volumes were similar in both groups. Diastolic function parameters were not significantly different between groups. There were no significant differences in age, gender, race, body mass index, dyslipidemia between the two groups. The findings show that patients with controlled RHTN have higher LVMI, but comparable diastolic function to those of patients with CHTN.
Perioperative risk factors for neurological impairment in infants with acute liver failure following liver transplantation
Authors: Ide Kentaro , Uchida Hajime , Sakamoto Seisuke , Hayakawa Itaru , Nakagawa Satoshi , Kobayashi Tohru , Ito Shuichi , Kasahara Mureo 
Published: April 2023

AbstractBackgroundNeurological impairment is not rare in infants with acute liver failure (ALF). This study aimed to investigate the perioperative risk factors for neurological impairment following liver transplantation (LT) in infantile ALF.MethodsRetrospective analysis was performed in infants who were younger than 1 year with ALF who subsequently underwent LT at our hospital between January 2005 and December 2016. Patients were considered to have neurological impairment if the Pediatric Cerebral Performance Category score was between 2 and 5 at the age of 6 years. A comparison between the groups of infants with and without neurological impairment was performed, and factors with p < .10 in the comparison were analyzed using univariate logistic regression analysis for neurological impairment.ResultsTwenty‐six infants survived until 6 years of age, and 31% (8/26) of them had neurological impairment. Patients with neurological impairment were significantly younger in age at ALF onset, had significantly higher pre‐LT bilirubin and prothrombin time/international normalized ratio, and stayed significantly longer in the intensive care unit than those without neurological impairment. Total bilirubin (odds ratio (OR) = 1.12, 95% confidence interval (CI) 1.02–1.22, p = .012), indirect bilirubin (OR = 1.10, 95% CI 1.01–1.20, p = .025), direct bilirubin (OR = 1.22, 95% CI 1.01–1.47, p = .040), and age in month at ALF (OR = 0.76, 95% CI 0.58–0.999, p = .049) showed significant association with neurological impairment.ConclusionsHigh pre‐LT peak bilirubin value and younger age at ALF onset can be perioperative risk factors for neurological impairment after LT in infantile ALF.
Patients’ opinions 10 years after receiving encapsulated porcine islet xenotransplantation without immunosuppression
Authors: Matsumoto Shinichi , Abalovich Adrian , Wynyard Shaun , Carulla Mariana E. , Abalovich David 
Published: April 2023

AbstractBackgroundPreviously we performed clinical encapsulated neonatal porcine islet transplantation under comprehensive regulation, and demonstrated the efficacy and safety. To analyze the patients’ quality of life (QOL), we assessed patients’ opinions 10 years after islet xenotransplantation.MethodsTwenty‐one type 1 diabetic patients received microencapsulated neonatal porcine islet transplants in Argentina were enrolled. Seven patients were enrolled in efficacy and safety study and 14 patients were enrolled in safety studies. Patients’ opinions related to the current and pre‐transplant status of diabetes control, blood glucose levels, severe hypoglycemia, and hyperglycemia required hospitalization were analyzed. In addition, opinions related to islet xenotransplantation were assessed.ResultsAt the time of this survey, average HbA1c was still significantly lower compared to pre‐transplantation (8.5 ± 0.9 (%) at pre‐transplant and 7.4 ± 0.5(%) at the survey, p < .05) and average insulin dose were also lower (0.95 ± 0.32 (IU/kg) at pre‐transplant and 0.73 ± 0.27 (IU) at the survey). The majority of patients improved diabetes control (71%), blood glucose levels (76%), severe hypoglycemia (86%) and hyperglycemia required hospitalization (76%), and no patients deteriorated in all of the categories when compared with pre‐transplantation. No patients had cancer, or psychological problem, and one patient had a serious adverse event. The majority of patients wanted to recommend this treatment to other patients (76%) and receive booster transplantation (85.7%).ConclusionsThe majority of patients had positive opinions related to the encapsulated porcine islet xenotransplantation 10 years after transplantation.
Stress load and volunteer motivation of patient volunteers in Fangcang shelter hospitals in Shanghai, China during the COVID-19 pandemic: a cross-sectional survey
Authors: Gu Liyan , Liu Fengmei , Wang Ji , Li Jie , Wei Jie , Xu Jiping 
Published: April 2023

ObjectivesThis study aims to assess the volunteer motivation and stress load of patient volunteers in the Fangcang shelter hospitals (FSHs), examine their associations, and explore the potential influence factors of volunteer motivation.DesignCross-sectional online survey conducted from 21 April to 20 May 2022.SettingQuestionnaires were collected from patient volunteers selected by random cluster sampling in the FSHs in Shanghai, China.Participants197 participants who met the inclusion criteria as patients who were asymptomatic or presenting with mild symptoms in the FSHs and who volunteered to assist with routine work under quarantined settings.Outcome measuresWe investigated sociodemographic information, stress load and volunteer motivation through an online survey using the Volunteer Function Inventory and the Stress Overload Scale. Comparisons between groups were conducted by applying t-tests or analysis of variance. The correlation between volunteer motivation and stress was analysed by Pearson correlation. Influencing factors of volunteer motivation were determined by multivariable linear regression models. A value of p<0.05 was used to declare statistical significance.ResultsThe mean score of volunteer motivation of patient volunteers was 73.24 (SD 12.00), while that of stress load was 46.08 (SD 21.28). The mean scores of the personal vulnerability (PV) and event load (EL), two dimensions of stress load, were 26.99 (SD 12.46) and 19.09 (SD 9.63), respectively. The majority of the participants (136, 69.04%) were grouped in the low (PV)-low (EL) stress category. Participants’ volunteer motivation was negatively correlated with stress load (r=−0.238, p<0.001), as well as PV (r=−0.188, p<0.01) and EL (r=−0.283, p<0.001). Multivariable linear regression analysis identified that the potential influencing factors of volunteer motivation were occupation (B=1.100, 95% CI 0.037 to 2.164, p=0.043), health condition (B=−3.302, 95% CI −5.287 to –1.317, p<0.001) and EL (B=−0.434, 95% CI −0.756 to –0.111, p=0.009). Participants who worked in the public sector, had better health conditions and had lower EL were more likely to have higher volunteer motivation.ConclusionsOur study suggested that reducing stress load might be a possible pathway to encourage and maintain volunteerism in the FSH context. Implications and suggestions for future research on patient volunteer recruitment and management could be drawn from our findings.
Investigating the effect of early life antibiotic use on asthma and allergy risk in over 600 000 Canadian children: a protocol for a retrospective cohort study in British Columbia and Manitoba
Authors: Lishman Hannah , Nickel Nathan C , Sbihi Hind , Xie Max , Mamun Abdullah , Zhang Bei Yuan , Rose Caren , Janssen Patricia , Roberts Ashley , Azad Meghan B , Turvey Stuart , Patrick David M 
Published: April 2023

IntroductionAllergic conditions, such as asthma, hay fever and eczema, are some of the most common conditions impacting children globally. There is a strong incentive to study their determinants to improve their prevention. Asthma, hay fever and eczema are influenced through the same immunological pathway and often copresent in children (‘the atopic march’). Increasing evidence shows a link between infant antibiotic use and the risk of childhood atopic conditions, mediated through gut microbial dysbiosis during immune system maturation, however, the potential for confounding remains. This study will investigate the relationship between infant antibiotic use and risk of allergic conditions in British Columbian and Manitoban children born over 10 years, adjusting for relevant confounders.Methods and analysisProvincial administrative datasets will be linked to perform comparable retrospective cohort analyses, using Population Data BC and the Manitoba Population Research Data Repository. All infants born between 2001 and 2011 in BC and Manitoba will be included (approximately 460 000 and 162 500 infants, respectively), following up to age 7. Multivariable logistic regression will determine the outcome risk by the fifth birthday among children who did and did not receive antibiotics before their first birthday. Clinical, demographic and environmental covariates will be explored, and sensitivity analyses performed to reduce confounding by indication.Ethics and disseminationThe University of British Columbia Research Ethics Board (H19-03255) and University of Manitoba Ethics Board (HS25156 (H2021:328)) have approved this study. Data stewardship committees for all administrative datasets have granted permissions, facilitated by Population Data BC and the Manitoba Centre for Health Policy. Permissions from the Canadian Health Infant Longitudinal Development Study are being sought for breastfeeding data (CP185). Findings will be published in scientific journals and presented at infectious disease and respiratory health conferences. A stakeholder committee will guide and enhance sensitive and impactful communication of the findings to new parents.
Violence against nurses in the emergency department: an observational study
Authors: Chazel Muriel , Alonso Sandrine , Price Jane , Kabani Sarah , Demattei Christophe , Fabbro-Peray Pascale 
Published: April 2023

ObjectiveThis study aimed to evaluate the number and risk factors of violent events encountered in the emergency department. An observation grid was developed following interviews with emergency department staff to target the most pertinent information to collect in a prospective study design.DesignObservational study.SettingEmergency department of a tertiary hospital in France.Outcome measuresNumber of violent events occurring during a single shift, recorded over 6 months by two observers. Information collected included time and date of incident; number of male/female staff; number of patients and accompaniers present in the service and the waiting room and length of staff debriefing. Perpetrator, victim and patient information were collected. Victims were followed-up 72 hours later.ResultsEighty-two periods were observed between November 2015 and April 2016 recording 35 violent incidents affecting 37 perpetrators and 48 victims, equally distributed over the days of the week and months of the year. The median interval until violence was 0 [0–96] min from entry. Eight (23%) events were officially reported, with two (6%) resulting in charges being pressed. No risk factors were significantly associated with violent incidents in multivariate analysis, although there was a tendency towards significance for fewer senior female doctors present (p=0.0787) and a resulting longer debriefing session (p=0.0712).ConclusionsWe confirm the high rate of violence in the emergency department and poor level of official reporting. Strategies should be implemented to anticipate and reduce incidence and encourage reporting by affected staff.Trial registration numberNCT02116439.
Impact of lifting the mandatory evacuation order after the Fukushima Daiichi Nuclear Power Plant accident on the emergency medical system: a retrospective observational study at Minamisoma City with machine learning analysis
Authors: Yoshimura Hiroki , Yamamoto Chika , Sawano Toyoaki , Nishikawa Yoshitaka , Saito Hiroaki , Nonaka Saori , Zhao Tianchen , Ito Naomi , Tashiro Satoshi , Ozaki Akihiko , Oikawa Tomoyoshi , Tsubokura Masaharu 
Published: April 2023

ObjectivesThis study aimed to identify factors that delayed emergency medical services (EMS) in evacuation order zones after the 2011 Great East Japan Earthquake and Fukushima Daiichi Nuclear Power Plant accident and to investigate how the lifting of the evacuation affected these factors over time.DesignThis research was a retrospective observational study. The primary outcome measure was onsite EMS time. A gradient boosting model and a decision tree were used to find the boundary values for factors that reduce EMS.SettingThe target area was Minamisoma City, Fukushima, Japan that was partly designated as an evacuation order zone after the 2011 Fukushima disaster, which was lifted due to decreased radiation.ParticipantsThis study included patients transferred by EMS from 1 January 2013 through 31 October 2018. Patients who were not transported and those transported for community events, interhospital patient transfer and natural disasters were excluded.Outcome measuresThis study evaluated the total EMS time using on-site time which is the time from arrival at the scene to departure to the destination, and other independent factors.ResultsThe total number of transports was 12 043. The decision tree revealed that the major factors that prolonged onsite time were time of day and latitude, except for differences by year. While latitude was a major factor in extending on-site time until 2016, the effect of latitude decreased and that of time of day became more significant since 2017. The boundary was located at N37.695° latitude.ConclusionsThe onsite time delay in EMS in evacuation order zones is largely due to regional factors from north to south and the time of day. However, the north-south regional factor decreased with the lifting of evacuation orders.
China Glaucoma Treatment Pattern Study I–Primary Angle-Closure Glaucoma: protocol for a multicentre, retrospective, observational study
Authors: Chen Jinyuan , Du Jie , Xing Xiaoli , Liu Danyan , Jia Zhiyang , Zheng Yajuan , Wang Dan , Guo Wenyi , Jiang Jian , Duan Guoping , Tang Li , Wu Zhengzheng , Lv Peng , Ma Jianjun , Zhu Yihua , Liang Yuanbo , Sun Xin , He Mingguang 
Published: April 2023

IntroductionPrimary angle-closure glaucoma (PACG) is a leading cause of irreversible blindness globally, and the number of patients with PACG rises every year. Yet, there is a lack of knowledge about the clinical characteristics, therapeutic options and profile of patients with PACG in China. Hence, we design the China Glaucoma Treatment Pattern Study Ⅰ–Primary Angle-Closure Glaucoma (Ch-GTPⅠ). The objective of this paper is to describe the design and methodology of Ch-GTP. The aim of this study is to characterise the profile and trend associated with initial PACG treatment for the last 10 years in China.MethodsCh-GTPⅠ is a national multicentre retrospective observational study that will randomly sample from 50 hospitals throughout China. Over 7000 patient records hospitalised for initial PACG treatment from 2011 to 2020 will be selected randomly. The data from electronic medical records will be uploaded to an encrypted online platform that will receive and collate data from all collaborating hospitals. Data abstraction and monitoring will be performed in a standardised manner by trained statisticians to ensure consistency. Systematic data cleaning will also be conducted by statisticians to ensure data integrity before final data storage. The outcomes will include four broad categories: (1) demographics, (2) clinical characteristics, (3) therapeutic strategies and procedures and (4) early outcomes at discharge. The demographic characteristics and early outcomes will be summarised using descriptive statistics. Comparative analyses of characteristics and treatment pattern changing trends for different regions and years will be used to test for significant differences (t-test or Mann-Whitney U test).Ethics and disseminationThe collaborating hospitals obtained local approval based on a standard ethics application from internal ethics committees or acknowledged an existent ethics approval of the leading institution with approval from internal ethics committees. Due to the retrospective nature, written informed consent from patients was waived by the ethics committee. The results will be published in academic journals and presented at national and international academic conferences.Trial registration numberChiCTR2100054643.
An image is worth a thousand words
Authors: Teoh Victoria , Shariff Zakir 
Published: April 2023

IntroductionThis case involved a 15-year-old boy, who slipped and impaled his left hand on a wooden beam. An initial anterior–posterior radiograph was obtained prior to referral to plastic surgery for further management (figure 1).Figure 1Clinical photographs and initial X-ray taken of the impalement injury.Clinical examination was restricted due to access. The patient reported general pain on limited movement of all digits but normal neurology. He received appropriate initial treatment of broad-spectrum antibiotics and tetanus care in the emergency department. His medical and social history were unremarkable.QuestionWhat is the next most appropriate intervention?Immediate removal of the impaled structure under tourniquet control in an operating theatre.Immediate removal of the impaled structure in the emergency department under nerve block.Further imaging is needed.Urgent surgical consultation.
Testing of a novel Valsalva Assist Device with supine and modified positions in healthy volunteers
Authors: FitzGerald Isabel , Ewings Paul , Lang Iain , Appelboam Andy 
Published: April 2023

BackgroundThe Valsalva manoeuvre (VM) is used to treat supraventricular tachycardia (SVT) by inducing a vagal response (drop in HR). There is debate as to the best position in which to carry out the VM and how the strain should be delivered in practice. We aimed to compare vagal responses induced with supine and modified VMs using strains delivered with a standardised manometer or novel Valsalva Assist Device (VAD), a simple device to provide resistance to exhalation.MethodsWe conducted a repeated measures randomised trial of four VMs (two supine VM and two modified VMs), in healthy adult volunteers, with strains delivered using an adapted sphygmomanometer (manometer) or a VAD. Changes in HR, pressure and duration of strain and adverse events were monitored and compared between the techniques and devices. The trial was approved by the University of Exeter Medical School Research ethics committee.Results75 healthy participants aged 19–55 years were recruited over a 4-month period. A mixed-effects linear regression showed the modified VM resulted in a 3.8 beats per min (bpm) greater drop in HR compared with the supine VM (p=0.002, 95% CI 2.2 to 5.4). VM strains produced by the VAD were of a similar pressure but of slightly shorter duration and resulted in a 1.9 bpm smaller drop in HR compared with the manometer (p=0.01, 95% CI 0.4 to 3.4). There were no differences in adverse events.ConclusionsModified VM was associated with a greater drop in HR than a supine VM with no increase in adverse events in healthy volunteers. The VAD can be used to safely generate the recommended VM strain pressure, but produced a smaller drop in HR compared with a manometer and requires modification to enable the recommended strain duration to be achieved consistently.Trial registration numberNCT03298880.
Abstract 1011: Hsa_circ_0116796 as a novel biomarker for predicting prognosis of human hepatocellular carcinoma
Authors: Do Huiwon , Kim Gyeonghwa , Lee Yu Rim , Tak Won Young , Park Soo Young , Hur Keun 
Published: April 2023

Abstract
Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related deaths worldwide. It lacks sufficient diagnostic and prognostic markers, which leads to a poor prognosis. The survival rate of HCC patients is still low due to its highly metastatic nature. According to recent studies, non-coding RNAs play a vital role in cancer pathogenesis and may be a new diagnostic target for HCC. Circular RNA (circRNA) is a type of non-coding RNA with a closed loop structure formed by mRNA back-splicing. Its functions are miRNA sponging, translating to proteins and gene regulation. Recently, it has been found that circRNAs play a potential role at angiogenesis, metastasis, and drug resistance in many types of cancers. Thus, we aim to investigate the clinical relevance of hsa_circ_0116796 in HCC.Total RNAs from 100 pairs of HCC and corresponding normal liver (NL) tissues with different stages were extracted using QIAzol. CircRNA primers were coded including the gap junction for specificity. The expression levels were determined by quantitative real-time PCR (qRT-PCR), and its expression was normalized with GAPDH. In addition, we analyzed the correlation between hsa_circ_0116796 expression and various clinicopathological features of HCC patients. The target miRNAs were predicted in silico analyses. We found that hsa_circ_0116796 was significantly decreased in HCC tumor tissues compared to corresponding NL tissues (P&lt;0.001). Suppression of hsa_circ_0116796 expression was associated with HCC progression (P&lt;0.001). Moreover, hsa_circ_0116796 expression was significantly associated with T-stage (P=0.009), TNM stage (P=0.005), BCLC stage (P=0.0132), and survival (P&lt;0.001). We provided the novel evidence for usefulness of hsa_circ_0116796 expressions as strong potential biomarkers for diagnosis and predicting prognosis of HCC patients.
Citation Format: Huiwon Do, Gyeonghwa Kim, Yu Rim Lee, Won Young Tak, Soo Young Park, Keun Hur. Hsa_circ_0116796 as a novel biomarker for predicting prognosis of human hepatocellular carcinoma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 1011.