bluuebunny/crossref_metadata_2025_split huggingface dataset:
Membrane metalloendopeptidase (MME) is positively correlated with systemic lupus erythematosus and may inhibit the occurrence of breast cancer
Authors: Ding Jiatong , Li Chenxi , Shu Kexin , Chen Wanying , Cai Chenxi , Zhang Xin , Zhang Wenxiong 
Published: August 2023

Background
Patients with systemic lupus erythematosus (SLE) have a lower risk of breast cancer (BRCA) than the general population. In this study, we explored the underlying molecular mechanism that is dysregulated in both diseases.

Methods
Weighted gene coexpression network analysis (WGCNA) was executed with the SLE and BRCA datasets from the Gene Expression Omnibus (GEO) website and identified the potential role of membrane metalloendopeptidase (MME) in both diseases. Then, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses of related proteins and miRNAs were performed to investigate the potential molecular pathways.

Results
WGCNA revealed that MME was positively related to SLE but negatively related to BRCA. In BRCA, MME expression was significantly decreased in tumor tissues, especially in luminal B and infiltrating ductal carcinoma subtypes. Receiver operating characteristic (ROC) analysis identified MME as a valuable diagnostic biomarker of BRCA, with an area under the curve (AUC) value equal to 0.984 (95% confidence interval = 0.976–0.992). KEGG enrichment analysis suggested that MME-related proteins and targeted miRNAs may reduce the incidence of BRCA in SLE patients via the PI3K/AKT/FOXO signaling pathway. Low MME expression was associated with favorable relapse-free survival (RFS) but no other clinical outcomes and may contribute to resistance to chemotherapy in BRCA, with an AUC equal to 0.527 (P value < 0.05).

Conclusions
In summary, MME expression was significantly decreased in BRCA but positively correlated with SLE, and it might reduce the incidence of BRCA in SLE patients via the PI3K/AKT/FOXO signaling pathway.
Da África ao Brasil: reflexões histórico-culturais para o ensino antirracista
Authors: Araújo Camila Beatriz Da Silva , Goldstein Thais Rotenberg 
Published: August 2023

Este artigo tem como objetivo descrever as etapas de trabalho de uma sequência didática aplicada com o 4º ano do Ensino Fundamental 1, em uma escola particular na zona oeste de São Paulo (SP). O trabalho desenvolvido visa ampliar os conhecimentos dos alunos sobre o contexto histórico e social na África e América coloniais, ressaltando os principais acontecimentos entre os séculos XVI a XIX, assim como os impactos da diáspora negra na sociedade brasileira contemporânea. Com o intuito de desconstruir preconceitos e despertar a empatia, a sequência didática foi desenvolvida por meio de atividades provocativas, analíticas e reflexivas, sendo possível evidenciar as origens dos elementos culturais afrobrasileiros, os impactos socioeconômicos da escravização e do processo abolicionista para a população negra, o racismo estrutural no Brasil e a importância da representatividade negra na política e na mídia como forma de resistência.
Nonlinear PDE Models in Semi-relativistic Quantum Physics
Authors: Möller Jakob , Mauser Norbert J. 
Published: August 2023

Abstract
We present the self-consistent Pauli equation, a semi-relativistic model for charged spin-

1
/
2

1/2

particles with self-interaction with the electromagnetic field.
The Pauli equation arises as the

O
⁢

(

1
/
c

)

O(1/c)

approximation of the relativistic Dirac equation.
The fully relativistic self-consistent model is the Dirac–Maxwell equation where the description of spin and the magnetic field arises naturally.
In the non-relativistic setting, the correct self-consistent equation is the Schrödinger–Poisson equation which does not describe spin and the magnetic field and where the self-interaction is with the electric field only.
The Schrödinger–Poisson equation also arises as the mean field limit of the 𝑁-body Schrödinger equation with Coulomb interaction.
We propose that the Pauli–Poisson equation arises as the mean field limit

N
→
∞

N\to\infty

of the linear 𝑁-body Pauli equation with Coulomb interaction where one has to pay extra attention to the fermionic nature of the Pauli equation.
We present the semiclassical limit of the Pauli–Poisson equation by the Wigner method to the Vlasov equation with Lorentz force coupled to the Poisson equation which is also consistent with the hierarchy in

1
/
c

1/c

of the self-consistent Vlasov equation.
This is a non-trivial extension of the groundbreaking works by Lions & Paul and Markowich & Mauser, where we need methods like magnetic Lieb–Thirring estimates.
High order immersed hybridized difference methods for elliptic interface problems
Authors: Jeon Youngmok 
Published: August 2023

Abstract
We propose high order conforming and nonconforming immersed hybridized difference (IHD) methods in two and three dimensions for elliptic interface problems. Introducing the virtual to real transformation (VRT), we could obtain a systematic and unique way of deriving arbitrary high order methods in principle. The optimal number of collocating points for imposing interface conditions is proved, and a unique way of constructing the VRT is suggested. Numerical experiments are performed in two and three dimensions. Numerical results achieving up to the 6th order convergence in the L
2-norm are presented for the two dimensional case, and a three dimensional example with a 4th order convergence is presented.
Linguistic expressions of despondency: an investigation of Sangness-related Chinese catchwords
Authors: Song Yehui , Xue Junkai , Ma Yali , Mo Junhua 
Published: August 2023

Abstract
Catchwords, as important social and cultural symbols, are the barometer of a country’s society and culture. In China, various catchwords are coined and used every year by Chinese people, especially the young. Of these catchwords, one particular type that expresses despondency or Sangness is increasingly gaining scholarly attention. This study takes a socio-linguistic approach to investigating the most frequently used Sangness-related Chinese catchwords in the past ten years. By examining the annual top ten catchwords selected by Biting Words and Chewing Words between 2013 and 2022, it finds that the most frequently used Sangness-related Chinese catchwords in the past decade have been (1) Ge You Slouch, (2) feeling awful and wanting to cry, (3) Buddha-like, (4) 996 work schedule, (5) life is too hard for me, (6) laborer, (7) involution, (8) lying flat, and (9) mental internal friction. These catchwords mainly serve the functions of deconstructing mainstream values, expressing self-mockery, and seeking value recognition. The development of these Sangness-related catchwords is characterized by an increasing diversity and a stronger applicability.
Generalized double Lindley distribution: A new model for weather and financial data
Authors: Satheesh Kumar C. , Jose Rosmi 
Published: August 2023

Abstract
In this paper, we introduce a generalization of the two-parameter double Lindley distribution (TPDLD) of Kumar and Jose
[C. S. Kumar and R. Jose,
A new generalization to Laplace distribution,
J. Math. Comput. 31 2020, 8–32],
namely the generalized double Lindley distribution (GDLD) along with its location-scale extension (EGDLD). Then we discuss the estimation of parameters of the EGDLD by the maximum likelihood estimation procedure. Next, we illustrate this estimation procedure with the help of certain real life data sets, and a simulation study is carried out to examine the performance of various estimators of the parameters of the distribution.
Clinical laboratory testing in the emergency department: a six-year analysis
Authors: Beştemir Attila , Bozdereli Berikol Göksu 
Published: August 2023

Abstract

Objectives
This study aimed to examine the utilization of clinical laboratory services in the emergency department and to identify the changes in their usage over six years.

Methods
Our study is a retrospective descriptive observational study. The study includes emergency room visits between January 01, 2016, and January 01, 2022, and the analysis of the tests requested during this period.

Results
When the number of tests requested among the patients in the emergency departments was considered, the highest rate belonged to complete blood count (109,696,468), which was followed by creatinine (98,027,489) and potassium (94,583,831). In addition to an increase in the number of C-reactive protein (CRP) tests (118.82 %), coagulation parameters such as D-dimer (1,180.95 %) and fibrinogen (315.25 %) showed an increasing trend after the onset of pandemia.

Conclusions
The most frequently used tests in the emergency department were complete blood count, creatinine, potassium, blood urine nitrogen (BUN), aspartate aminotransferase (AST), alanine aminotransferase (ALT), and Na, ferritin, fibrinogen, CRP, and D-dimer have increased over the last two years due to their clinical use in predicting the outcome of COVID-19.
Forum—Centering Discomfort in Global Music History
Authors: Law (Convenor) Hedy , Bloechl Olivia , Perea Jessica Bissett , Carrico Alexandria , Wangpaiboonkit Parkorn , Palomino Pablo , Castro Pantoja Daniel F. 
Published: August 2023

This forum presents a conversation among seven scholars who explore the theme of discomfort in the emergent field of global music history. Prompted by Yvonne Liao and Olivia Bloechl, co-founders of the American Musicology Society’s Global Music History Study Group in 2019, these contributions address ideas of globality by decentering knowledge production and productively engage different ways to resist hegemonic pasts, narratives, and processes entrenched at home, whatever and wherever home may be. This forum thus confronts home-based challenges that resist or obstruct the implementation of this decentering principle: What does it mean to locate a “home” and to identify various “discomforts” in the global musical and sonic spheres? How does the thinking of “home” relative to “discomfort” help to theorize the concepts of agency, locality, temporality, community, regionalism, and nationality?
All seven articles share one structural feature––an extensive self-introduction in the spirit of Jessica Bissett Perea’s call for “intertribal visiting protocols” developed by critical Indigenous studies. This grounds each contribution by exposing the contingency of arguments and allows for a weaving of themes of space, boundary, and interconnection across articles. The forum’s topics range from world-making to relationality, from cripping musical taste to making Siamese music legible to colonial ears, and from listening for political taboos to problematizing “Latin American” music and theorizing intimacy through the notion of “scale” itself. Writing with candor, all contributors bring global music history into uncomfortable terrains.
Propuesta de formación e-learning para el mejoramiento de competencias laborales técnicas en el personal de soldadura del sector metalmecánico en Colombia
Authors: Esteban Ojeda Catherine , Delgado Candia Vicky 
Published: August 2023

Se desarrolló una estrategia para mejorar las competencias laborales técnicas, que requiere el personal de soldadura del sector metalmecánico en Colombia, mediante una propuesta (curso) de formación virtual (e-learning), bajo el modelo instruccional ADDIE (análisis, diseño, desarrollo, implementación y evaluación) en su construcción y ejecución. Así mismo, es importante resaltar que los programas de formación actuales son en su gran mayoría presenciales.
Durante el análisis, se hizo la revisión de la bibliografía, esencial en el diagnóstico de las competencias laborales técnicas. En las fases de diseño y desarrollo, las dinámicas giraron alrededor del conocimiento, la motivación frente al aprendizaje autónomo y la dimensión pedagógica como base. En la implementación y la evaluación, las actividades se integraron en la secuencia didáctica, midiendo la eficacia y eficiencia de la formación.
Al finalizar, se identificó que la propuesta (curso) e-learning es el adecuado para la formación virtual. Las respuestas de los participantes en la encuesta final y el juicio del experto confirmaron la contribución al progreso de las competencias técnicas, lo que condujo a una mejoría en su productividad y competitividad en este sector del país.
Estrategia didáctica para la construcción de competencias ciudadanas mediante el uso de las TIC y de los saberes intergeneracionales
Authors: Parra Contreras María Isabel , Gómez Martínez María Trinidad , Moreno Cubides Wilson , Pinilla Elluz Tatiana 
Published: August 2023

El objetivo general del proyecto fue aplicar una estrategia didáctica para promover la construcción de competencias ciudadanas en estudiantes de educación básica de dos municipios santandereanos con vocación agrícola y población rural, a partir de la investigación sobre saberes intergeneracionales con apoyo de las tecnologías de la información y la comunicación. La metodología de corte cualitativo, permitió contemplar la investigación educativa como un proceso de búsqueda de opciones que iluminan la práctica pedagógica. En la primera fase se caracterizaron las estrategias didácticas implementadas por docentes de la región; a partir de entrevistas y el análisis de los registros de guías y cuadernos de estudiantes en tiempos de aislamiento preventivo y alternancia; en la segunda fase se diseñó la estrategia con la participación de docentes; en la tercera fase se aplicó la estrategia en tres aulas; la última fase consistió en el proceso de reflexión sobre los resultados obtenidos. Entre los principales resultados se encuentra el paso a paso de la estrategia didáctica, aplicada en tres aulas de clase y a partir de la cual se promovió la investigación sobre los saberes tradicionales de la región. Como conclusiones se presenta la necesidad de seguir capacitando y acercando, tanto a docentes como estudiantes rurales, a las tecnologías de la información y la comunicación y al uso educativo de los aparatos electrónicos disponibles; el trabajo en comunidad y a partir de temas del entorno cercano es una oportunidad para conectar a los estudiantes con sus familias, sus saberes, y aprovechar didácticamente el celular.
Evolution of artificial intelligence for application in contemporary materials science
Authors: Gupta Vishu , Liao Wei-keng , Choudhary Alok , Agrawal Ankit 
Published: August 2023

AbstractContemporary materials science has seen an increasing application of various artificial intelligence techniques in an attempt to accelerate the materials discovery process using forward modeling for predictive analysis and inverse modeling for optimization and design. Over the last decade or so, the increasing availability of computational power and large materials datasets has led to a continuous evolution in the complexity of the techniques used to advance the frontier. In this Review, we provide a high-level overview of the evolution of artificial intelligence in contemporary materials science for the task of materials property prediction in forward modeling. Each stage of evolution is accompanied by an outline of some of the commonly used methodologies and applications. We conclude the work by providing potential future ideas for further development of artificial intelligence in materials science to facilitate the discovery, design, and deployment workflow.Graphical abstract
New Insight on the Active Fault System in the Halmahera Volcanic Arc, Indonesia, Derived from the 2022 Tobelo Earthquakes
Authors: Simanjuntak Andrean V. H. , Palgunadi Kadek Hendrawan , Supendi Pepen , Daryono Daryono , Prakoso Tio A. , Muksin Umar 
Published: August 2023

Abstract
On 9 January 2022, two shallow earthquakes occurred in the east arm of Halmahera, Indonesia, with magnitudes of Mw 5.2 and 5.4 felt at III–V modified Mercalli intensity. The existence of the causative fault for the earthquakes was unknown. One possible explanation is that the earthquakes were caused by the activity of an inactive fault striking in the southeast–northwest direction, and possibly linked to the volcanic activities in Halmahera. Thus, further analysis of their characteristics is crucial to identify the previously an inactive fault. In this study, we relocated the associated earthquake hypocenters using the double-difference method with an updated velocity model, and determined the focal mechanisms by employing full waveform inversion using moment tensor analysis. The focal parameters were used to analyze the static stress changes. The relocated hypocenters show specific hypocenter clusters, aligning in the north–south direction, associated with left-lateral faulting mechanisms. This north–south alignment differs from the northeast–southwest trend of some other active faults in Halmahera. We propose that the newly found Tobelo fault dips at an angle of around 80° to the west. The seismic stress change from the mainshock and the foreshock of the Tobelo earthquakes corresponds with the distribution of the aftershocks. A detailed analysis of unidentified faults in the high seismicity area is essential to comprehend the tectonic study of Halmahera Island and its seismic hazard assessments.
Continuation of Events Detection with Global Long-Period Seismic Data: An Analysis from 2010 to 2022
Authors: Poli Piero 
Published: August 2023

Abstract
We develop an algorithm to detect and locate sources of long-period (25–100 s) seismic signals. Our method is based on the analysis of seismological data recorded at global networks, plus all available stations at latitude larger (smaller) than 60° (−60°). We use a delay and stack method to identify coherent Rayleigh waves generated at the free surface of the Earth. The application of our approach to 13 yr of continuous data permitted us to detect more than 36,000 events. After a precise analysis to classify known events and to remove spurious detections, we report more than 1700 previously unidentified source of long-period seismic signals. Each source is characterized by its location (with associated uncertainty) and moment magnitude. This new catalog mainly reveals sources in the polar regions likely associated with glaciers dynamics but also volcanic activity, landslides, and regular earthquakes located in remote areas of the planet. Our study reveals the importance of maintaining global seismic networks and exploring the recorded data, beyond providing new observations that can be the basis to future studies to better characterize physical processes occurring at the free surface of our planet.
Alginate Profile, Antioxidant, and Antibacterial Activities of Brown Algae <I>Sargassum cristaefolium</I> from Pane Island, North Sumatera
Authors: Dewinta Astrid Fauzia , Susetya Ipanna Enggar , Khairunnisa Khairunnisa , Suriani Mai , Addina Syahira , Fadhilah Amanatul 
Published: August 2023

Highlight Research

Alginate content produced by Sargassum cristaefolium in three different parts of the thallus has food grade quality.
The alginate chemical profile of cristaefolium in three different thallus part had a significant effect.
Antioxidant activity of cristaefolium extract was in the moderate category.
Antibacterial activity of cristaefolium extract against aquatic pathogenic bacteria has moderate and strong effectiveness.

Abstract
Sargassum, an ubiquitous variant of algae in North Sumatera, has grown wildly on Pane Island with the type, namely, Sargassum cristaefolium. This study aimed to determine the characteristics of alginates, antioxidative ability, and antibacterial ability. Alginate was extracted via the acid pathway method from three different parts of the thallus and was then characterized physically and chemically. Antioxidant activity using the DPPH method and the total phenol with a gallic acid standard. Antibacterial activity using the well diffusion method. The characteristics of alginate include yields of 53.61% ± 2.21%, viscosity of 11.44 ± 1.54 cPs, whiteness index of 56.55 ± 1.71, acidity degrees of 9.83 ± 0.34, moisture content of 9.63% ± 0.53%, ash content of 23.17% ± 0.76%, Pb and Hg levels of 0.065 ± 0.01 ppm, 0.034 ± 0.003 ppm. The IC50 value of antioxidant activity being 134.408 ± 0.04 ppm, moderate category. Extract concentration of 8 mL can inhibit the E. coli and E. tarda with inhibitions of 10.60 ± 0.72, 14.03 ± 2.97 mm. Although other pathogenic bacteria can be inhibited optimally at an extract concentration of 10 mL with inhibitions of 11.03 ± 1.43, 9.07 ± 0.20, 11.20 ± 1.56, 12.80 ± 3.01 mm. Alginates isolated in S.cristaefolium from Pane Island met food grade standards except for its viscosity. S. cristaefolium from Pane Island is a moderate antioxidant. Likewise, its antibacterial ability was moderate however it was strong against aquatic gram-negative bacteria.
ENHANCEMENT OF MOTHERS AND CADRE ROLES IN FIRST 1.000 DAYS OF LIFE AS STUNTING PREVENTION AND DETECTION AT THE MOROKREMBANGAN PRIMARY HEALTH CENTER SURABAYA
Authors: Prasetiowati Lucky , Sulistiawati  , Widati Fatmaningrum  , Eighty Mardiyan Kurniawati  , Hanna Dyahferi Anomsari  , Rimbun  
Published: August 2023

Stunting is a condition in which children under five years old fail to thrive due to chronic malnutrition in the first 1000 days of life and the height is below the height chart (<-2 SD) on standard age. Although stunting has negative great impact on the child growth and development, parents frequently are not concert about it due to lack of information regarding stunting. The COVID-19 pandemic also contributes on fulfillment of nutritious food, non-routine checks for the child growth and development at the posyandu, and even stopped posyandu activities. Therefore, it is still challenging to detect the incidence of stunting in the community. This program aims to increase the knowledge and raise awareness of the importance of the first 1000 days if life in a child's growth and development also to increase the cadre skill in the early detection of stunting. The community service activity was held in the area of the Morokrembangan Primary Health Center include health promotion and training for early detection of stunting through anthropometric examination for posyandu cadre, pregnancy mother and mother of under 5 years old child. Evaluation was done by measuring the increasing of participants knowledge about stunting through pretest and posttest. There was a significant difference (p = 0.000) between the pretest and posttest. It means that this program activities have succeeded in increasing the knowledge of mothers and cadre. A better understanding of the first 1000 days of life can improve people's behavior to prevent stunting in community.
On the determination of the quadratic pencil of the Sturm-Liouville operator with an impulse
Authors: Khalili Yasser , Baleanu Dumitru 
Published: August 2023

Abstract
In this work, an inverse problem for the quadratic pencil of the Sturm-Liouville operator with an impulse in the finite interval is considered. It is shown that some information on eigenfunctions at some internal point b ∈ (1/2, 1) and parts of two spectra uniquely determine the potential functions and all parameters in the boundary conditions. Moreover we prove that the potential functions on the whole interval and the parameters in the boundary conditions can be established from one spectrum and the potentials prescribed on (1/2, 1).
2010 MSC: 34A37, 65L09, 47A10.