bluuebunny/crossref_metadata_2025_split huggingface dataset:
Low von Willebrand Disease: A Bleeding Disorder of Unknown Cause?
Authors: O'Donnell James S. , Baker Ross I. 
Published: February 2023

Abstractvon Willebrand disease (VWD) represents the most common inherited bleeding disorder. The majority of VWD cases are characterized by partial quantitative reductions in plasma von Willebrand factor (VWF) levels. Management of patients with mild to moderate VWF reductions in the range of 30 to 50 IU/dL poses a common clinical challenge. Some of these low VWF patients present with significant bleeding problems. In particular, heavy menstrual bleeding and postpartum hemorrhage can cause significant morbidity. Conversely, however, many individuals with mild plasma VWF:Ag reductions do not have any bleeding sequelae. In contrast to type 1 VWD, most patients with low VWF do not have detectable pathogenic VWF sequence variants, and bleeding phenotype correlates poorly with residual VWF levels. These observations suggest that low VWF is a complex disorder caused by variants in other genes beyond VWF. With respect to low VWF pathobiology, recent studies have shown that reduced VWF biosynthesis within endothelial cells likely plays a key role. However, pathological enhanced VWF clearance from plasma has also been described in approximately 20% of low VWF cases. For low VWF patients who require hemostatic treatment prior to elective procedures, tranexamic acid and desmopressin have both been shown to be efficacious. In this article, we review the current state of the art regarding low VWF. In addition, we consider how low VWF represents an entity that appears to fall between type 1 VWD on the one hand and bleeding disorders of unknown cause on the other.
Immune Plasma for the Treatment of COVID-19: Lessons Learned so far
Authors: Schrezenmeier Hubert , Hoffmann Simone , Hofmann Henrike , Appl Thomas , Jahrsdörfer Bernd , Seifried Erhard , Körper Sixten 
Published: February 2023

AbstractCOVID-19 convalescent plasma (CCP) has been explored as one of the treatment options for COVID-19. Results of many cohort studies and clinical trials have been recently published. At first glance, the results of the CCP studies appear to be inconsistent. However, it became clear that CCP is not beneficial if CCP with low anti-SARS-CoV-2 antibody concentrations is used, if it is administered late in advanced disease stages, and to patients who already mounted an antibody response against SARS-CoV-2 at the time of CCP transfusion. On the other hand, CCP may prevent progression to severe COVID-19 when very high-titer CCP is given early in vulnerable patients. Immune escape of new variants is a challenge for passive immunotherapy. While new variants of concern developed resistance to most clinically used monoclonal antibodies very rapidly, immune plasma from individuals immunized by both a natural SARS-CoV-2 infection and SARS-CoV-2 vaccination retained neutralizing activity against variants. This review briefly summarizes the evidence on CCP treatment to date and identifies further research needs. Ongoing research on passive immunotherapy is not only relevant for improving care for vulnerable patients in the ongoing SARS-CoV-2 pandemic, but even more as a model for passive immunotherapy in case of future pandemics with a newly evolving pathogen. Compared to other drugs, which must be newly developed in a pandemic (e.g., monoclonal antibodies, antiviral drugs), convalescent plasma is rapidly available, inexpensive to produce, and can be adaptive to viral evolution by selection of contemporary convalescent donors.
„Ein voller Bauch schläft nicht gut“ – Salutogener Therapieansatz durch Integration der Mayr-Medizin bei Schlafstörungen
Authors: Fegerl Sepp 
Published: February 2023

ZusammenfassungDer gesunde Schlaf ist vielfältigen Störeinflüssen ausgesetzt. Der Verdauungstrakt spielt dabei eine große Rolle. Werden Patientinnen und Patienten mit dem ganzen Spektrum an Schlafstörungen nach den Diagnosekriterien nach Mayr zur Darmgesundheit untersucht, liegt in den meisten Fällen ein überforderter Darm bzw. Verdauungstrakt vor, die den ganzen Organismus belasten. Noch bevor ein medizinischer Krankheitswert erkennbar wird, kann eine Mayr-Therapie präventiv oder kurativ eingesetzt und dadurch können Stoffwechselvorgänge günstig beeinflusst werden: Gewicht, ektopes und viszerales Fett, zirkadianer Rhythmus, Darmgesundheit, Entzündungs-, Hormon- und Immunmodulation, besonders aber auch die Lebensstilfaktoren Ernährung, Bewegung und vegetative Balance.
Pathophysiologie der Schlafapnoe
Authors: Hohmann Claas 
Published: February 2023

ZusammenfassungObstruktiven Schlafapnoen liegen meist mechanische Ursachen zugrunde. Zumeist handelt es sich um Fettablagerungen in den oberen Atemwegen sowie um eine Verringerung des Lungenvolumens, was zu einem Verlust der kaudalen Traktion der oberen Atemwege führt. Aufgrund des Umstands, dass 60–80% der Betroffenen eine Ernährungsstörung im Sinne einer Adipositas aufweisen, rücken adipöse und darmgestörte Patienten in den Vordergrund. Auch wenn die gesamten Zusammenhänge noch nicht vollständig erforscht sind, zeigt sich, dass der bei Adipösen stark vergrößerte Anteil an viszeralem Fett als endokrines Organ zur Pathogenese der obstruktiven Schlafapnoe beiträgt. Weitere Ursachen der obstruktiven Schlafapnoe können ein meist unbemerkter nächtlicher laryngopharyngealer Reflux sowie intestinale Intoxikationen sein. Der Beitrag beleuchtet die Pathophysiologie der Schlafapnoen unter ernährungs- und darmspezifischen Aspekten und beschreibt davon ausgehende Therapieansätze außerhalb der bekannten konventionellen Verfahren.
Update Motorisches Lernen (3) Instruktionen
Authors: Huber Martin 
Published: February 2023

ZusammenfassungMit der verbalen Instruktion der Patient*innen lässt sich Aufmerksamkeit und Lernen fördern. Sie ist ein wesentlicher Teil des Therapie- und Lernprozesses, hat ihren Platz im Lernrad und kann reflektiert und zielgerichtet eingesetzt werden.
47.1.4.11 Synthesis of Alkenes by α,β-Dehydrogenation
Authors: Jie X. , Su W. 
Published: February 2023

AbstractThis review describes methods for the synthesis of alkenes by elimination, with a specific focus on α,β-dehydrogenation reactions. It covers the literature published in the period 2011 to early 2020, providing an overview of recently developed transition-metal-catalyzed methods for α,β-desaturation of carbonyl compounds (e.g., ketones, aldehydes, esters, amides, etc.) as well as other functional groups. Key methods covered include palladium-catalyzed dehydrogenation via β-hydride elimination and copper-catalyzed desaturation via a radical pathway, as well as other miscellaneous methods. These approaches provide efficient access to α,β-unsaturated carbonyl compounds, which are important intermediates in the synthesis of diverse valuable organic molecules.
Enhanced terahertz nonlinear response of GaAs by the tight field confinement in a nanogap
Authors: Kim Dasom , Kim Dai-Sik , Choi Geunchang 
Published: February 2023

We demonstrated that an incident terahertz peak field amplitude below 0.01 MV/cm can trigger Zener tunneling in a semi-insulating GaAs. Moreover, a transmission decrease with an extinction ratio of 60% was observed in the semi-insulating GaAs with an electric field strength of up to 46 MV/cm (maximum incident peak field of ∼0.29 MV/cm). These experimental results were realized by taking advantage of the nonlinear effects, such as Zener tunneling, impact ionization, and metal–insulator–metal tunneling in 5 nm metallic nanogaps on the GaAs; a strong field was locally confined in the vicinity of these gaps. The 5 nm gap enabled us to lower the voltage across the gap to suppress impact ionization while allowing Zener tunneling. Simulation results indicated that the effective thickness of the semiconductor increased as a function of the gap size. The approach used in this study decreases the threshold incident electric field for nonlinear responses as well as paves the way toward ultrathin high-speed electronic devices and ultrafast light pumps.
Prediction of battery capacity based on improved model of support vector regression
Authors: Liu Lizhao , Huang Yankai , Huang Shaobing 
Published: February 2023

Abstract
The state of Health (SOH) of new energy lithium batteries is an important indicator to describe the energy decline of new energy, especially the battery decline. It is very important for the service life of new energy equipment, especially equipment based on a lithium battery. Its internal is a high-dimensional nonlinear complex chemical reaction. In this paper, the state of Health (SOH) of a lithium battery is defined according to the capacity to turn the problem of new energy battery capacity into a new problem. At the same time, the multi-dimensional complex nonlinear regression problem is mapped into the physical space, which is described by the phenomenon of the combined action of the quantum radiation field and the quantum gravitational repulsion force in the physical space, and the corresponding quantum radiation equation and abstract equation are used. Finally, the NASA Ames Research Center battery data set is used to verify the results. The verification shows that the algorithm can accurately predict the capacity of the battery to know the SOH of the battery. The model has good learning accuracy, operation speed, and generalization ability.
Research on the construction of new energy microgrids for wind power generation based on green and low carbon
Authors: Yu Changle , Zhang Shuo , Ji Yanchen , Xu Peng 
Published: February 2023

Abstract
At present, the supply mode of fossil fuel as energy in China has caused more and more damage to the environment. In order to meet the demand for sustainable development, research on the construction of new energy microgrids for wind power generation based on green and low-carbon is proposed. Firstly, the equivalent model of the wind power generation system is established, and then the wind power generation new energy microgrid with a wind turbine as the core is built based on the specific value calculated by the model. Finally, the conventional new energy microgrid construction scheme is selected as the comparative object, and the comparative experiment is carried out to prove the practicability of the method. The comparative experimental results show that the microgrid constructed by the proposed green and low-carbon wind power generation new energy microgrid construction method is superior to the traditional construction scheme in operating power, can meet the green and low-carbon energy development needs, and can provide a reference value for similar research schemes.
Research and Analysis of One-button Sequential Control for GIS
Authors: Ding Pengxiang , Yang Chunyue , Lv Xunhao , Wang Yanyi , Li Huaiyu 
Published: February 2023

Abstract
One-button sequential control is one of the advanced applications of the intelligent substation, which is the key technology to promote the deep integration of modern information technology and power grid technology and to construct intelligent operation and inspection systems. Traditional switching depends on manual operation and has a great risk of misoperation. The application of one-button sequential control can effectively reduce misoperation and improve the safety level of power grid switching operations. Through the analysis and research on the key technology of one-button sequential control and combined with the action characteristics and position requirements of the moving contact of disconnector in the opening or closing process, the test analysis method and test control technical requirements of the one-button sequential control are put forward, which provides a certain technical basis for the control and design of the one-button sequential control in the future.
A Triboelectric Transduction Mechanism from Flow-Induced Low-frequency Structural Resonance
Authors: Li Xiaowei , Zhou Yuan , Li Zhongjie , Zhang Dan , Wu Hao , Gong Ying , Zhang Di , Peng Xuzhang 
Published: February 2023

Abstract
A triboelectric nanogenerator (TENG) based on the vortex-induced vibrational resonance is proposed to collect the kinetic flow energy of rivers and oceans. A prototype was fabricated to study the performance of the harvester. Experiments were conducted at flow velocities below 1 m/s. The results show that when flow velocity reaches a low level, the mechanism starts to vibrate; thus, the voltage can be generated, and the voltage increases with the growth of flow velocity. When flow velocity reaches a medium level, the structural resonance take place, resulting in the maximum amplitude of the device and voltage outputs which does not increase further with the growth of flow velocity. When flow velocity reaches a high level, the vortex-induced resonance phenomenon disappears so that amplitude and voltage decrease. The experimental results demonstrate the feasibility of using TENG to harvest vortex-induced vibration energy.
Research on modulation recognition of underwater acoustic communication signal based on deep learning
Authors: Li Yuanyuan , Liang Shucheng 
Published: February 2023

Abstract
Marine information technology plays a important role in the development of marine resources development, marine climate early warning, and other industries. Underwater acoustic communication technology can help us better access marine information. The performance of the underwater acoustic signal modulation recognition algorithm depends on the accuracy of feature extraction. however, due to excessive underwater noise, many traditional algorithms can not recognize features well. For this reason, this paper proposes a modulation recognition network for aquatic communication signals based on deep learning. ResNet can capture the characteristics of deep features and combines ResNet with a modulation recognition network. Finally, the experiment proves the effectiveness of this method.
Continuous-cooling-transformation Diagrams for Boron-low Carbon Micro Alloy Hot Rolled Enamel Steel
Authors: Fu Xuejing , Xu Chun 
Published: February 2023

Abstract
The addition of Element B to micro-alloyed low-carbon steels helps to improve the scale burst resistance of the enameled steel while being able to improve the strength properties of the base steel. It is known that the differences in alloy content change the phase transition temperature and CCT diagram. To test the phase transformation temperature and CCT diagram of B-micro-alloys low carbon steel, this paper uses the thermal expansion method to determine the transformation temperatures Ac1, Ac3, Ar1, and Ar3 with a Gleeble-1500 thermal simulator, and conducts hot compression experiments at 950 °C with a true strain of 0.3 and strain rate of 10 s−1, followed by cooling to room temperature at 0.1, 0.5, 1, 5, 10, and 25 °C/s rates of cooling to room temperature. Based on the expansion diagrams, metallography and hardness are combined to determine the microstructure composition at the corresponding cooling rates. Therefore, the CCT diagrams are plotted. The results show that when the cooling rate is less than 5 °C/s, the phase transformation consists of ferrite and a very small amount of pearlite; when the cooling rate is greater than 5 °C/s, it consists of ferrite, a small amount of pearlite, and bainite, and when the cooling rate is from 5 °C/s to 25 °C/s, it consists of ferrite and bainite.
Analysis of basic performance parameters and temperature effect of SiC-MOSFET
Authors: Li Yaoye 
Published: February 2023

Abstract
With the development of science and technology, traditional silicon-based semiconductor devices can no longer support the development of science and technology. As a new material, silicon carbide has many advantages. In this paper, the working principle of MOSFET is studied, and the characteristics of silicon carbide are sorted and analyzed, based on which the influence of temperature on the basic parameters of the MOSFET device is further studied. It is concluded that temperature affects the leakage current through the influence of threshold voltage drop and carrier: when the device operating voltage is high, the mobility determines the leakage current; at low operating voltage, the threshold voltage determines the leakage current. The research on temperature characteristics of SiC MOSFET is improved in this paper, which promotes the development of microelectronics technology.
The application of coffee husk ash to improve compaction characteristics of clay soil
Authors: Munirwan R P , Mohd Taib A , Taha M R , Abd Rahman N , Munirwansyah M 
Published: February 2023

Abstract
Soil stabilization is the modification process of one or more soil properties mechanically or chemically to generate an improved soil material with the appropriate engineering properties. Recently, stabilization methods utilizing commonly used stabilizing agents are becoming more costly. On the other hand, there is an increasing interest in identifying new green technologies that may be used to improve construction practices. As a result, the search for new materials and improved processes for processing local materials has moved to a priority. Thus, this study was conducted to validate the effectiveness of coffee husk ash (CHA) as a stabilizing agent on the compaction characteristics of clayey soil. To characterize the properties of clayey soil admixed with varying concentrations of CHA, Atterberg limits, grain size distribution, and standard proctor compaction tests were conducted. The soil was mixed with CHA in concentrations ranging from 5% to 25% by dry weight of the soil. Observation indicates CHA progressively enhances soil compaction performance. The pozzolanic and hydration reactions between CHA and the soil may have made the soil more likely to be compacted.
Treatment of Wastewater by Moringa Oleifera and Maize Seeds as Plant-Based Coagulant
Authors: Kasmuri N , Shokree N S A , Zaini N , Ismail N , Miskon M F , Ramli N H , Nayono S E 
Published: February 2023

Abstract
Coagulants are essential in purifying raw water for drinking water safety for consumers. Commonly, aluminium sulphate, a chemical coagulant, is used for water treatment. However, for long-term usage, chemical coagulants can be considered toxic and harmful to the environment due to the accumulation of this substance in the pipeline system, which can create severe health issues if consumed. The natural plant-based coagulant can be a substitute for a sustainable solution in the water treatment coagulation process. This research aimed to determine the efficiency of plant-based materials as coagulants in surface water treatment. Moringa oleifera and maize seeds were chosen as natural coagulants in this investigation since they are both locally available plant-based materials. Here, this research aims to study the ability of moringa oleifera seed and maize seed as plant-based coagulants in enhancing the effluent quality of the wastewater treatment plant of UiTM Dengkil Selangor. A jar test experiment was used to assess the capacity of moringa oleifera and maize as natural coagulants. The results comprise turbidity removal by 92% (mixed of moringa oleifera seed and maize seed), the chemical oxygen demand (COD) of 95% reduction rate using moringa oleifera seed. The biochemical oxygen demand (BOD) for 88% removal by moringa oleifera seed, ammonia-nitrogen removal of 12% (moringa oleifera seed) and total suspended solids (TSS) of 100% reduction rate using mixed moringa oleifera seed and maize seed for the effluent sample. Thus, it can be recognized that moringa oleifera and maize seeds can be an alternative solution to replace the chemical coagulants in the treatment systems.
Thermal analysis under static and fatigue conditions on HDPE
Authors: Santonocito D , Cucinotta F , Guglielmino E , Risitano G 
Published: February 2023

Abstract
High Density Polyethylene (HDPE) represents one of the best choices for water and gas distribution pipeline thanks to its light weight and good mechanical performance. One of the strengths of this plastic material is the possibility to join it via welding adopting a procedure according to the standard. However, the welding procedure can severally alter the mechanical performance of the material under service loads. In the present work comparison between virgin and welded HDPE specimens is carried out adopting rapid approaches, such as the Risitano’s Thermographic Method and the Static Thermographic Method, monitoring the evolution of the specimen’s superficial temperature under static tensile and fatigue tests. Mechanical performance has been compared, as well as the fatigue limit obtained with traditional fatigue tests, showing good agreement. Reliable fatigue data have been obtained in a very short amount of time and with few specimens by adopting Energy Methods.
Influence of the wear rings on the buckling behaviour of hydraulic actuators
Authors: Arcieri E V , Baragetti S 
Published: February 2023

Abstract
During their use, hydraulic actuators are generally subjected to compressive loads which can induce buckling. In this work the critical load of a hydraulic actuator was determined for various boundary conditions and types of wear rings by theoretical and numerical models. In the theoretical model, the actuator was modelled as two connected beams, with different sections. The contribution of the wear rings on the critical load of the actuator was determined through numerical simulation based on the finite element method. The results of the mathematical model are similar to the results provided by the finite element analyses. The contribution of the investigated wear rings stiffness is very low for the materials considered for these components in this paper.
Shape optimization of 2D beam-structures to obtain the uniform strength
Authors: Iandiorio C , Milani D , Salvini P 
Published: February 2023

Abstract
This paper provides a new method to design the optimal shape of 2D frame structures even (or especially) if not statically determined. The optimization here addressed involves obtaining the uniform strength of the whole structure, but the proposed procedure can be followed for other optimization goals. Two types of beam cross-sections are studied, in which the solution in terms of balance, kinematic and beam-shape is found analytically and involves six unknowns for every beam element. For frame structures, some internal and external constraint conditions must be satisfied; using the analytical solution within the boundary conditions, the optimization problem boils down to finding the roots of a non-linear system. This way allows to work inside the optimization workspace, avoiding the use for each iteration of other solvers (e.g. F.E. software) and obtaining the solution with a high-computation speed. Two tests are shown, which result in a uniform-strength behaviour of the maximal stress at every cross section, and a lightness gain higher than 70% by respect to the reference initial structure. This technique can be extended to other types of cross-sections or 3D frame structures.