bluuebunny/crossref_metadata_2025_split huggingface dataset:
Climate‐informed forecasts reveal dramatic local habitat shifts and population uncertainty for northern boreal caribou
Authors: Stewart Frances E. C. , Micheletti Tatiane , Cumming Steven G. , Barros Ceres , Chubaty Alex M. , Dookie Amanda L. , Duclos Isabelle , Eddy Ian , Haché Samuel , Hodson James , Hughes Josie , Johnson Cheryl A. , Leblond Mathieu , Schmiegelow Fiona K. A. , Tremblay Junior A. , McIntire Eliot J. B. 
Published: February 2023

AbstractMost research on boreal populations of woodland caribou (Rangifer tarandus caribou) has been conducted in areas of high anthropogenic disturbance. However, a large portion of the species' range overlaps relatively pristine areas primarily affected by natural disturbances, such as wildfire. Climate‐driven habitat change is a key concern for the conservation of boreal‐dependent species, where management decisions have yet to consider knowledge from multiple ecological domains integrated into a cohesive and spatially explicit forecast of species‐specific habitat and demography. We used a novel ecological forecasting framework to provide climate‐sensitive projections of habitat and demography for five boreal caribou monitoring areas within the Northwest Territories (NWT), Canada, over 90 years. Importantly, we quantify uncertainty around forecasted mean values. Our results suggest habitat suitability may increase in central and southwest regions of the NWT's Taiga Plains ecozone but decrease in southern and northwestern regions driven by conversion of coniferous to deciduous forests. We do not project that boreal caribou population growth rates will change despite forecasted changes to habitat suitability. Our results emphasize the importance of efforts to protect and restore northern boreal caribou habitat despite climate uncertainty while highlighting expected spatial variations that are important considerations for local people who rely on them. An ability to reproduce previous work, and critical thought when incorporating sources of uncertainty, will be important to refine forecasts, derive management decisions, and improve conservation efficacy for northern species at risk.
Recent fire in a Mediterranean ecosystem strengthens hoverfly populations and their interaction networks with plants
Authors: Nakas Georgios , Kantsa Aphrodite , Vujić Ante , Mescher Mark C. , De Moraes Consuelo Μ. , Petanidou Theodora 
Published: February 2023

AbstractFire affects many critical ecological processes, including pollination, and effects of climate change on fire regimes may have profound consequences that are difficult to predict. Considerable work has examined effects of fire on pollinator diversity, but relatively few studies have examined these effects on interaction networks including those of pollinators other than bees. We examined the effects of a severe wildfire on hoverfly pollinators in a Mediterranean island system. Using data collected over 3 consecutive years at burnt and unburnt sites, we documented differences in species diversity, abundance, and functional traits, as well as hoverfly interactions with flowering plants. Hoverfly abundance and species richness peaked during the first post‐fire flowering season (year 1), which coincided with the presence of many opportunistic species. Also in year 1, hoverfly pollination networks were larger, less specialized, more nested, and less modular at burnt (vs. unburnt) sites; furthermore, these networks exhibited higher phylogenetic host‐plant diversity. These effects declined over the next 2 years, with burnt and unburnt sites converging in similarity to hoverfly communities and interaction networks. While data obtained over 3 years provide a clear timeline of initial post‐fire recovery, we emphasize the importance of longer‐term monitoring for understanding the responses of natural communities to wildfires, which are projected to become more frequent and more destructive in the future.
Combination of pimitespib (TAS‐116) with sunitinib is an effective therapy for imatinib‐resistant gastrointestinal stromal tumors
Authors: Teranishi Ryugo , Takahashi Tsuyoshi , Obata Yuuki , Nishida Toshirou , Ohkubo Shuichi , Kazuno Hiromi , Saito Yurina , Serada Satoshi , Fujimoto Minoru , Kurokawa Yukinori , Saito Takuro , Yamamoto Kazuyoshi , Yamashita Kotaro , Tanaka Koji , Makino Tomoki , Nakajima Kiyokazu , Hirota Seiichi , Naka Tetsuji , Eguchi Hidetoshi , Doki Yuichiro 
Published: February 2023

AbstractDespite the effectiveness of imatinib, most gastrointestinal stromal tumors (GISTs) develop resistance to the treatment, mainly due to the reactivation of KIT tyrosine kinase activity. Sunitinib, which inhibits the phosphorylation of KIT and vascular endothelial growth factor (VEGF) receptor, has been established as second‐line therapy for GISTs. The recently‐developed heat shock protein 90 (HSP90) inhibitor pimitespib (PIM; TAS‐116) demonstrated clinical benefits in some clinical trials; however, the effects were limited. The aim of our study was therefore to clarify the effectiveness and mechanism of the combination of PIM with sunitinib for imatinib‐resistant GISTs. We evaluated the efficacy and mechanism of the combination of PIM with sunitinib against imatinib‐resistant GIST using imatinib‐resistant GIST cell lines and murine xenograft models. In vitro analysis demonstrated that PIM and sunitinib combination therapy strongly inhibited growth and induced apoptosis in imatinib‐resistant GIST cell lines by inhibiting KIT signaling and decreasing auto‐phosphorylated KIT in the Golgi apparatus. In addition, PIM and sunitinib combination therapy enhanced antitumor responses in the murine xenograft models compared to individual therapies. Further analysis of the xenograft models showed that the combination therapy not only downregulated the KIT signaling pathway but also decreased the tumor microvessel density. Furthermore, we found that PIM suppressed VEGF expression in GIST cells by suppressing protein kinase D2 and hypoxia‐inducible factor‐1 alpha, which are both HSP90 client proteins. In conclusion, the combination of PIM and sunitinib is effective against imatinib‐resistant GIST via the downregulation of KIT signaling and angiogenic signaling pathways.
Network orchestration in a large inter‐organizational project
Authors: Roehrich Jens K. , Kalra Jas , Squire Brian , Davies Andrew 
Published: February 2023

AbstractMultiple organizations working jointly on shared activities in inter‐organizational projects for a defined period of time are used increasingly to coordinate the supply of complex products, subsystems, and services across many industries. Despite the growth in inter‐organizational networks as an organizational form, scholars have only recently begun to identify how lead organizations orchestrate the coordination of multiple parties with disparate goals, responsibilities, and capabilities. Prior work offers limited insights into the choice of network governance forms, and how coordination is undertaken by the network orchestrator to govern these networks. We conducted a longitudinal study of four networks to deliver vital services into a large project. We identified how the choice of network governance form was based on task complexity. A shared governance form was chosen for networks developed to deliver routine services, whereas a lead organization governance form was chosen for networks set up to deliver complex services. However, findings showed that the selection of an appropriate governance form was not sufficient for ensuring high performance. The network orchestrator's mode of coordination (formal or informal), the intensity of coordination (active or passive), and fit with the form of governance form (shared or lead organization governed) was important in driving performance.
Dose‐Dependent Glucocorticoid Regulation of Transcription Factors in Vocal Fold Fibroblasts and Macrophages
Authors: Nakamura Ryosuke , Bing Renjie , Gartling Gary J. , Garabedian Michael J. , Branski Ryan C. 
Published: February 2023

ObjectiveVariable outcomes of glucocorticoid (GC) therapy for laryngeal disease are putatively due to diverse interactions of the GC receptor (GR) with cell signaling pathways, limited consideration regarding concentration‐dependent effects, and inconsistent selection of GCs. In the current study, we evaluated the concentration‐dependent effects of three frequently administered GCs on transcription factors with an emphasis on the phosphorylation of GR at Ser203 and Ser211 regulating the nuclear translocation of GR. This study provides foundational data regarding the diverse functions of GCs to optimize therapeutic approaches.Study designIn vitro.MethodsHuman vocal fold fibroblasts and THP1‐derived macrophages were treated with different concentrations of dexamethasone, methylprednisolone, and triamcinolone in combination with IFN‐γ, TNF‐α, or IL4. Phosphorylated STAT1, NF‐κB family molecules, and phosphorylated STAT6 were analyzed by Western blotting. Ser211‐phosphorylated GR (S211‐pGR) levels relative to GAPDH and Ser203‐phosphorylated GR (S203‐pGR) were also analyzed.ResultsGCs differentially altered phosphorylated STAT1 and NF‐κB family molecules in different cell types under IFN‐γ and TNF‐α stimuli. GCs did not alter phosphorylated STAT6 in IL4‐treated macrophages. The three GCs were nearly equivalent. A lower concentration of dexamethasone increased S211‐pGR/GAPDH ratios relative to increased S211‐pGR/S203‐pGR ratios regardless of cell type and treatment.ConclusionThe three GCs employed in two cell lines had nearly equivalent effects on transcription factor regulation. Relatively high levels of Ser203‐phosphorylation at low GC concentrations may be related to concentration‐dependent differential effects of GCs in the two cell lines.Level of EvidenceNA Laryngoscope, 133:2704–2711, 2023
Pulmonary arteries segmentation from CT images using PA‐Net with attention module and contour loss
Authors: Yuan Chengyan , Song Shuni , Yang Jinzhong , Sun Yu , Yang Benqiang , Xu Lisheng 
Published: February 2023

AbstractBackground: Pulmonary embolism is a kind of cardiovascular disease that threatens human life and health. Since pulmonary embolism exists in the pulmonary artery, improving the segmentation accuracy of pulmonary artery is the key to the diagnosis of pulmonary embolism. Traditional medical image segmentation methods have limited effectiveness in pulmonary artery segmentation. In recent years, deep learning methods have been gradually adopted to solve complex problems in the field of medical image segmentation.Purpose: Due to the irregular shape of the pulmonary artery and the adjacent‐complex tissues, the accuracy of the existing pulmonary artery segmentation methods based on deep learning needs to be improved. Therefore, the purpose of this paper is to develop a segmentation network, which can obtain higher segmentation accuracy and further improve the diagnosis effect.Methods: In this study, the pulmonary artery segmentation performance from the network model and loss function is improved, proposing a pulmonary artery segmentation network (PA‐Net) to segment the pulmonary artery region from 2D CT images. Reverse Attention and edge attention are used to enhance the expression ability of the boundary. In addition, to better use feature information, the channel attention module is introduced in the decoder to highlight the important channel features and suppress the unimportant channels. Due to blurred boundaries, pixels near the boundaries of the pulmonary artery may be difficult to segment. Therefore, a new contour loss function based on the active contour model is proposed in this study to segment the target region by assigning dynamic weights to false positive and false negative regions and accurately predict the boundary structure.Results: The experimental results show that the segmentation accuracy of this proposed method is significantly improved in comparison with state‐of‐the‐art segmentation methods, and the Dice coefficient is 0.938 ± 0.035, which is also confirmed from the 3D reconstruction results.Conclusions: Our proposed method can accurately segment pulmonary artery structure. This new development will provide the possibility for further rapid diagnosis of pulmonary artery diseases such as pulmonary embolism. Code is available at https://github.com/Yuanyan19/PA‐Net.
Synthesis and Biological Evaluation of Benzo[d] thiazolyl‐Sulfonyl‐Benzo[4,5]isothiazolo [2,3‐c][1,2,3] triazole Derivatives as EGFR Targeting Anticancer Agents
Authors: Ramya Sucharitha E. , Kumar Nukala Satheesh , Swamy Thirukovela Narasimha , Palabindela Rambabu , Sreerama Rakesh , Narsimha Sirassu 
Published: February 2023

AbstractA one‐step procedure for the synthesis of new fused Benzo[d]thiazolo‐1,2,3‐triazoles (3 a–3 h and 4 a–4 h) in good yields using sulfonylazides (2) and iodoalkyne (1) through from the 5‐iodo 1,2,3‐triazole generated in situ was developed. Among all, compounds 5‐chloro‐3‐(((1,1‐dioxidobenzo[d]thiazol‐2‐yl)sulfonyl)methyl)benzo[4,5]isothiazolo[2,3‐c] [1,2,3]triazole 8,8‐dioxide (3 e), 3‐(((1,1‐dioxidobenzo[d]thiazol‐2‐yl)sulfonyl)methyl)‐5‐fluorobenzo[4,5]isothiazolo [2,3‐c][1,2,3]triazole 8,8‐dioxide (3 f), 5‐bromo‐3‐(((5‐bromo‐1,1‐dioxidobenzo[d]thiazol‐2‐yl)sulfonyl)methyl)benzo [4,5]isothiazolo[2,3‐c][1,2,3]triazole 8,8‐dioxide (4 d), 3‐(((5‐bromo‐1,1‐dioxidobenzo[d]thiazol‐2‐yl)sulfonyl)methyl)‐5‐chlorobenzo [4,5]isothiazolo[2,3‐c][1,2,3]triazole 8,8‐dioxide (4 e) and 3‐(((5‐bromo‐1,1‐dioxidobenzo[d]thiazol‐2‐yl)sulfonyl)methyl)‐5‐fluorobenzo [4,5] isothiazolo[2,3‐c][1,2,3]triazole 8,8‐dioxide (4 f) showed superior activity against A‐549 and good activity against the MCF‐7. Later, in vitro EGFR results revealed that compounds 4 e and 4 f indicated promising potency with IC50 values of 0.316±0.07 and 0.211±0.09 μM respectively. In silico studies of five potent compounds were also carried out to identify interactions against EGFR receptors and found that the energy calculations were consistent with the IC50 values obtained. In silico pharmacokinetic profile was predicted for potent compounds 3 e, 3 f, 4 d, 4 e, and 4 f using SWISS/ADME and pkCSM, where, all the compounds followed the Lipinski rule without any deviation.
AIE gel exhibiting continuous gradient fluorescence based on a polar‐responsive AIE‐gen
Authors: Hu Ziqing , Zhang Hanwei , Liu Hui , Li Jinsa , Ji Xiaofan , Tang Ben Zhong 
Published: February 2023

AbstractTraditional multicolor fluorescent hydrogels are generated through the assembly of discrete fluorescent hydrogels, which is not a complete integration much distinct from living organisms. On the basis of aggregation‐induced emission (AIE), a special solvent polar‐responsive AIE molecule possessing a twisted intramolecular charge transfer (TICT) effect was noticed. By incorporating it into the gel network, an AIE gel that displays continuous gradient fluorescence was fabricated. First, hydrogel A containing the solvent polar‐responsive AIE‐gen was prepared to show orange fluorescence. After soaking in the organic solvents, the fluorescence color transition of hydrogel A ranging from orange to green occurred when being immersed in high‐polarity organic solvents ascribed to the embedded AIE‐gen owning TICT effect. Then, hydrogel A was successively lifted up from organic solvents. Due to the different immersion time of each section for the hydrogel, the polarity difference occurred. Then, the produced gel B showed continuous gradient fluorescence ranging from orange to green under the irradiation of UV light.
An algebra of observables for de Sitter space
Authors: Chandrasekaran Venkatesa , Longo Roberto , Penington Geoff , Witten Edward 
Published: February 2023

Abstract
We describe an algebra of observables for a static patch in de Sitter space, with operators gravitationally dressed to the worldline of an observer. The algebra is a von Neumann algebra of Type II1. There is a natural notion of entropy for a state of such an algebra. There is a maximum entropy state, which corresponds to empty de Sitter space, and the entropy of any semiclassical state of the Type II1 algebras agrees, up to an additive constant independent of the state, with the expected generalized entropy Sgen = (A/4GN) + Sout. An arbitrary additive constant is present because of the renormalization that is involved in defining entropy for a Type II1 algebra.
Techno-economic model-based design space exploration of ‘combined’ ship propulsion systems
Authors: Batra Amit , Sampath Suresh , Nikolaidis Theoklis , Pilidis Pericles 
Published: February 2023

AbstractThe architecture of a ship propulsion system, developed during early stages of the overall ship design process, has a very large impact on the overall design and performance of the ship. The design space exploration to arrive at the final ship propulsion architecture can be a rather complex process for high-performance 'combined' ship propulsion systems designed to achieve multiple, often conflicting, design objectives. This paper proposes a novel process for the process of design space exploration based on a model-based ‘Techno-economic & Environmental Risk Assessment’ (TERA) approach, executed using a hybrid ‘Multiple-Criteria Decision-Making’ (MCDM) procedure, to select a compromise solution from competing propulsion system architectures populating the design space. The process utilizes a combination of performance data generated from performance simulation of developed models, as well as comparative expert opinions-based metrics for information not available early in the ship design process for selection of a 'compromise solution'. The paper includes an illustrative example of application of the proposed process for design space exploration for a combined propulsion system architecture for a notional destroyer.
Donne transgender nello sport: è solo un problema di valori di testosterone?
Authors: Garofalo Vincenzo , Calogero Aldo E. 
Published: February 2023

SommarioIl Comitato Olimpico Internazionale (CIO) consente alle atlete transgender di gareggiare nelle divisioni femminili se i loro livelli di testosterone sierico sono inferiori a 10 nmol/L dal almeno un anno. Tuttavia, questo valore è nettamente superiore rispetto alle donne cisgender. Gli elevati livelli di testosterone e i loro effetti fisiologici determinano un vantaggio nelle competizioni sportive. La terapia ormonale di affermazione di genere riduce i livelli di testosterone circolante e determina alcune variazioni nella fisiologia del testosterone nelle donne transgender con conseguente modifica delle prestazioni fisiche di queste atlete. Scopo di questa Rassegna è la valutazione dei cambiamenti indotti dalla terapia ormonale e l’analisi degli effetti irreversibili del testosterone e di come essi possano influire sulle capacità fisiche e atletiche di donne transgender, con lo scopo finale di rendere lo sport inclusivo ed equo per tutti gli atleti.
Stimuli-Responsive Gene Delivery Nanocarriers for Cancer Therapy
Authors: Zhang Qingfei , Kuang Gaizhen , Li Wenzhao , Wang Jinglin , Ren Haozhen , Zhao Yuanjin 
Published: February 2023

AbstractGene therapy provides a promising approach in treating cancers with high efficacy and selectivity and few adverse effects. Currently, the development of functional vectors with safety and effectiveness is the intense focus for improving the delivery of nucleic acid drugs for gene therapy. For this purpose, stimuli-responsive nanocarriers displayed strong potential in improving the overall efficiencies of gene therapy and reducing adverse effects via effective protection, prolonged blood circulation, specific tumor accumulation, and controlled release profile of nucleic acid drugs. Besides, synergistic therapy could be achieved when combined with other therapeutic regimens. This review summarizes recent advances in various stimuli-responsive nanocarriers for gene delivery. Particularly, the nanocarriers responding to endogenous stimuli including pH, reactive oxygen species, glutathione, and enzyme, etc., and exogenous stimuli including light, thermo, ultrasound, magnetic field, etc., are introduced. Finally, the future challenges and prospects of stimuli-responsive gene delivery nanocarriers toward potential clinical translation are well discussed. The major objective of this review is to present the biomedical potential of stimuli-responsive gene delivery nanocarriers for cancer therapy and provide guidance for developing novel nanoplatforms that are clinically applicable.
First Confirmed Record of the Smalltooth Sand Tiger, Odontapis Ferox, in Galicia (NW Spain)
Authors: Mucientes Gonzalo , Vilas-Arrondo Nair , Secci-Petretto Giulia , Vázquez Uxía , Pin Xabier , López Alfredo , Castro L. Filipe C. , Froufe Elsa 
Published: February 2023

AbstractThe smalltooth sand tiger shark Odontaspis ferox (Risso, 1810) appears to have an extensive and fragmented distribution in tropical and warm-temperate worldwide oceans. One female of O. ferox was caught and released by a small-scale fishery vessel in Ría de Arousa (Northwest of Spain), subsequently stranded still alive on the coast (42°33’18.4"N 8°49’18.3"O) after a few hours. The individual (336 cm total length, weight ~ 300 kg) was identified based on a collection of features including the characteristic dentition, body morphology and by molecular assignment. This is the first confirmed record of O. ferox in Galician waters. This finding complements the knowledge of the geographic distribution and occurrence of this rare and sparse species in the Northeastern Atlantic.
Are Confident Parents Really Aware of Children’s Online Risks? A Conceptual Model and Validation of Parental Self-Efficacy, Mediation, and Awareness Scales
Authors: Kuldas Seffetullah , Sargioti Aikaterini , Staksrud Elisabeth , Heaney Darran , Norman James O’Higgins 
Published: February 2023

AbstractChildren’s use of the Internet comes with both risks and opportunities. To minimize risks and maximize opportunities, parents may choose to observe, enable, and/or restrict their children’s Internet use. However, parents’ high confidence in their children’s online safety can itself be a risk factor inhibiting parental awareness of online risks. This research aims to test whether confident parents are accurately aware of how frequently their child has experienced risks online. To this end, construct validity and reliability of scales measuring parental self-efficacy, restrictive-enabling-observant mediation, awareness, and Internet use were established first. Next, a conceptual model of parental awareness was proposed. These results were based on a two-parameter-logistic-model of item response theory, minimum-rank factor analysis, and parallel-mediation analysis of self-reports by a convenience sample of 388 parents in Ireland (Autumn 2019). Confident parents mostly reported their child experienced no online risk in the past couple of months, whereas unconfident parents reported their child experienced an online risk once, twice, or more times. Results of the mediation analysis indicated that confident parents likely underestimated, whereas unconfident parents overestimated, how frequently their child experienced an online risk. The accuracy of parental awareness depended on their mediation strategies, particularly restrictive mediation. Further research is needed to test whether training parents on self-efficacy and mediation of children’s Internet use raises their awareness of the children’s online risks.