bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intraoperative metabolic changes associated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy
Authors: Rubio-López Jesús David , Durán-Martínez Manuel , Moreno-Blázquez Andrea , Rodríguez-Ortiz Lidia , Rufián-Andújar Blanca , Valenzuela-Molina Francisca , Adam Ángela Casado , Sánchez-Hidalgo Juan M. , Rufián-Peña Sebastián , Romero-Ruiz Antonio , Briceño-Delgado J , Arjona-Sánchez Álvaro 
Published: January 2023

Abstract

Background
Cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) causes considerable hemodynamic, respiratory, and metabolic changes during the perioperative period.

Objectives
To evaluate metabolic changes associated with this procedure. Understanding perioperative factors and their association with morbidity may improve the perioperative management of patients undergoing this treatment.

Methods
A retrospective review of a prospectively maintained database was performed. All consecutive unselected patients who underwent CRS plus HIPEC between January 2018 and December 2020 (n = 219) were included.

Results
The mean age was 58 ± 11.7 years and 167 (76.3%) were female. The most frequent histology diagnosis was serous ovarian carcinoma 49.3% (n = 108) and colon carcinoma 36.1% (n = 79). Mean peritoneal cancer index was 14.07 ± 10.47. There were significant variations in pH, lactic acid, sodium, potassium, glycemia, bicarbonate, excess bases, and temperature (p < 0.05) between the pre-HIPEC and post-HIPEC periods. The closed HIPEC technique resulted in higher levels of temperature than the open technique (p < 0.05). Age, potassium level post-HIPEC potassium level, and pre-HIPEC glycemia were identified as prognostic factors for morbidity in multivariate analysis.

Conclusion
The administration of HIPEC after CRS causes significant changes in internal homeostasis. Although the closed technique causes a greater increase in temperature, it is not related to higher morbidity rates. The patient’s age, post-HIPEC potassium level, and pre-HIPEC glycemia are predictive factors for morbidity.
Electrochemistry at Krakowian research institutions
Authors: Skibińska Katarzyna , Żabiński Piotr 
Published: January 2023

AbstractThe electrochemistry research team activity from Poland is marked by significant increase in the last 20 years. The joining of European Community in 2004 gives an impulse for the development of Polish science. The development of electrochemistry has been stimulated by cooperation with industry and the establishment of technology transfer centers, technology parks, business incubators, etc. and the mostly by simplified international collaborations. Five research institutions from Krakow reports work in the field of electrochemistry. The achievements of all teams are briefly described.
Ulrich bundles on a general blow-up of the plane
Authors: Ciliberto Ciro , Flamini Flaminio , Knutsen Andreas Leopold 
Published: January 2023

AbstractWe prove that on $$X_n$$

X
n

, the plane blown-up at n very general points, there are Ulrich line bundles with respect to a line bundle corresponding to curves of degree m passing simply through the n blown-up points, with $$m\leqslant 2\sqrt{n}$$

m
⩽
2

n

and such that the line bundle in question is very ample on $$X_n$$

X
n

. We prove that the number of these Ulrich line bundles tends to infinity with n. We also prove the existence of slope-stable rank-r Ulrich vector bundles on $$X_n$$

X
n

, for $$n\geqslant 2$$

n
⩾
2

and any $$r \geqslant 1$$

r
⩾
1

and we compute the dimensions of their moduli spaces. These computations imply that $$X_n$$

X
n

is Ulrich wild.
Hemocompatibility and hemodynamic comparison of two centrifugal LVADs: HVAD and HeartMate3
Authors: Gil Antonio , Navarro Roberto , Quintero Pedro , Mares Andrea 
Published: January 2023

AbstractMechanical circulatory support using ventricular assist devices is a common technique for treating patients suffering from advanced heart failure. The latest generation of devices is characterized by centrifugal turbopumps which employ magnetic levitation bearings to ensure a gap clearance between moving and static parts. Despite the increasing use of these devices as a destination therapy, several long-term complications still exist regarding their hemocompatibility. The blood damage associated with different pump designs has been investigated profoundly in the literature, while the hemodynamic performance has been hardly considered. This work presents a novel comparison between the two main devices of the latest generation–HVAD and HM3–from both perspectives, hemodynamic performance and blood damage. Computational fluid dynamics simulations are performed to model the considered LVADs, and computational results are compared to experimental measurements of pressure head to validate the model. Enhanced performance and hemocompatibility are detected for HM3 owing to its design incorporating more conventional blades and larger gap clearances.
Extended Multimodal Flat Detector CT Imaging in Acute Ischemic Stroke: A Pilot Study
Authors: Hoelter Philip , Lang Stefan , Beuscher Vanessa , Kallmuenzer Bernd , Manhart Michael , Schwab Stefan , Doerfler Arnd 
Published: January 2023

AbstractBy using Flat detector computed tomography (FD-CT), a one-stop-shop approach in the diagnostic workup of acute ischemic stroke (AIS) might be achieved. Although information on upstream vessels is warranted, dedicated FD-CT protocols which include the imaging of the cervical vasculature are still lacking. We aimed to prospectively evaluate the implementation of a new multimodal FD-CT protocol including cervical vessel imaging in AIS patients. In total, 16 patients were included in this study. Eight patients with AIS due to large vessel occlusion (LVO) prospectively received a fully multimodal FD-CT imaging, including non-enhanced flat detector computed tomography (NE-FDCT), dynamic perfusion flat detector computed tomography (FD-CTP) and flat detector computed tomography angiography (FD-CTA) including cervical imaging. For comparison of time metrics and image quality, eight AIS patients, which received multimodal CT imaging, were included retrospectively. Although image quality of NE-FDCT and FD-CTA was rated slightly lower than NE-CT and CTA, all FD-CT datasets were of diagnostic quality. Intracerebral hemorrhage exclusion and LVO detection was reliably possible. Median door-to-image time was comparable for the FD-CT group and the control group (CT:30 min, IQR27-58; FD-CT:44.5 min, IQR31-55, p = 0.491). Door-to-groin-puncture time (CT:79.5 min, IQR65-90; FD-CT:59.5 min, IQR51-67; p = 0.016) and image-to-groin-puncture time (CT:44 min, IQR30-50; FD-CT:14 min, IQR12-18; p < 0.001) were significantly shorter, when patients were directly transferred to the angiosuite, where FD-CT took place. Our study indicates that using a new fully multimodal FD-CT approach including imaging of cervical vessels for first-line imaging in AIS patients is feasible and comparable to multimodal CT imaging with substantial potential to streamline the stroke workflow.
Die Ziele der gemeinsamen Agrarpolitik der Europäischen Union gem. Art. 39 AEUV im Lichte der aktuellen Reform
Authors: Kreitz Benedict 
Published: January 2023

ZusammenfassungDie gemeinsame Agrarpolitik der Europäischen Union (GAP) ist eine der ältesten vergemeinschafteten
Materien in Europa. Sie hat bis heute auf Grund der elementaren Notwendigkeit der Lebensmittelproduktion
eine existenziell wichtige Bedeutung für die europäische Gesellschaft, wie auch global mit Blick
auf die Relevanz Europas auf den Weltmärkten. Ferner ist ihre Gestaltung von besonderer Relevanz für
die Natur wegen der natürlichen Produktionsweise der Landwirtschaft und der einhergehenden Interkation
mit der Umwelt. Die GAP verfolgt dabei eine Reihe von Zielen, die enumerativ in Art. 39 AEUV aufgelistet
sind, und eine fundamentale Richtschnur bei der Gestaltung des Sekundärrechtsrahmens darstellen. Diese
Ziele sind auch vor dem Hintergrund der aktuellen Reform zu sehen, die zum neuen Jahr Gültigkeit erlangt.
Experimental investigations of a new highly ductile hold-down with adaptive stiffness for timber seismic bracing walls
Authors: Maître K. , Lestuzzi P. , Geiser M. 
Published: January 2023

AbstractAn efficient implementation of the capacity design requires high ductility combined with a low overstrength of the critical regions. Conventional timber connections do not generally offer such ideal combination, resulting in modest behaviour and relatively high overstrength factors. Inspired by the Buckling Restrained Brace a new hold-down has been developed where the timber wall directly acts as a casing. The new hold-down has been given an adaptive stiffness allowing the structure to be stiff in the wind, while becoming more flexible in the case of an earthquake. Furthermore, local crushing of the timber members is completely avoided, and the new hold-down could be replaced after an earthquake. Experimental investigations were performed on hold-down specimens. The results show ultimate displacement values vu,c of more than 30 mm in a cyclic test according to EN12512. Eleven Cross Laminated Timber shear walls, in which the new hold-down has been implemented, were tested following monotonic and static-cyclic tests procedures, with and without vertical load. A very high ductility has been achieved with almost no strength degradation, little pinching and limited overstrength.
Climate change adaptation behaviour of forest growers in New Zealand: an application of protection motivation theory
Authors: Villamor Grace B. , Wakelin Steve J. , Dunningham Andrew , Clinton Peter W. 
Published: January 2023

AbstractClimate change is likely to have significant impacts on the forestry sector in New Zealand. However, an understanding of how forest growers are reducing their risks from climate change impacts is still in its infancy. This paper applies the protection motivation theory to identify socio-psychological factors influencing forest growers’ adaptation to climate change. This study presents the survey results from 60 forest growers who have the combined responsibility for managing more than 70% of New Zealand’s plantation forests. We investigated whether their perceived response efficacy, self-efficacy and their understanding of response costs are predictors of their protective or adaptive measures. Based on our survey, risk reduction and risk spreading are the two types of protective measure frequently reported by the respondents to deal with climate risks. Consistent with the protection motivation theory, our findings show that respondents who are more likely to implement protective or adaptive measures if they perceive the threat severity to be high have high self-efficacy and resource efficacy, and exhibit low maladaptive responses such as evading and postponing behaviours. Furthermore, our findings also suggest that there is a low self-efficacy belief with strong maladaptive behaviour among the respondents that negatively influence their motivation to implement adaptation measures. This result provides guidance to policy makers, researchers and forest companies on how to make climate change adaptation efforts effective by considering the forest growers motivation to adapt to climate change.
Majorization-minimization-based Levenberg–Marquardt method for constrained nonlinear least squares
Authors: Marumo Naoki , Okuno Takayuki , Takeda Akiko 
Published: January 2023

AbstractA new Levenberg–Marquardt (LM) method for solving nonlinear least squares problems with convex constraints is described. Various versions of the LM method have been proposed, their main differences being in the choice of a damping parameter. In this paper, we propose a new rule for updating the parameter so as to achieve both global and local convergence even under the presence of a convex constraint set. The key to our results is a new perspective of the LM method from majorization-minimization methods. Specifically, we show that if the damping parameter is set in a specific way, the objective function of the standard subproblem in LM methods becomes an upper bound on the original objective function under certain standard assumptions. Our method solves a sequence of the subproblems approximately using an (accelerated) projected gradient method. It finds an $$\varepsilon$$
ε
-stationary point after $$O(\varepsilon ^{-2})$$

O
(

ε

-
2

)

computation and achieves local quadratic convergence for zero-residual problems under a local error bound condition. Numerical results on compressed sensing and matrix factorization show that our method converges faster in many cases than existing methods.
Lipoprotein receptors in ovary of eel, Anguilla australis: molecular characterisation of putative vitellogenin receptors
Authors: Babio Lucila , Damsteegt Erin L. , Lokman P. Mark 
Published: January 2023

AbstractLipoprotein receptors, including low-density lipoprotein receptor (LDLr) relatives (Lrs) and LDLr-related proteins (Lrps), belong to the LDLr supergene family and participate in diverse physiological functions. In this study, novel sequences of lr and lrp genes expressed in the ovary of the short-finned eel, Anguilla australis, during early gonadal development are presented. The genes encoding the LDLr-like, Lrp1-like, Lrp1b-like, Lrp3, Lrp4-like, Lrp5-like, Lrp6, Lrp10, Lrp11, Lrp12-like, and Lr11-like proteins were found and identified by sequence and structure analysis, in addition to phylogenetic analysis. Genes encoding proteins previously implicated in follicle development and vitellogenin (Vtg) uptake in oviparous vertebrates were also identified, i.e. lr8 (including lr8 + and lr8- variants) and lrp13; their identification was reinforced by conserved synteny with orthologues in other teleost fish. Compared to other lr/lrp genes, the genes encoding Lr8 + , Lr8-, and Lrp13 were highly expressed in ovary during early development, decreasing as oocyte development advanced when induced by hypophysation. Furthermore, lr8 + , lr8-, and lrp13 were dominantly expressed in the ovary when compared with 17 other tissues. Finally, this study successfully detected the expression of both lr8 variants, which showed different expression patterns to those reported in other oviparous vertebrates and provided the first characterisation of Lrp13 in Anguilla sp. We propose that lr8 + , lr8-, and lrp13 encode putative Vtg receptors in anguillid eels.
Life-history omnivory in the fairy shrimp Branchinecta orientalis (Branchiopoda: Anostraca)
Authors: Lukić Dunja , Pormehr Navid , Beladjal Lynda , Vad Csaba F. , Ptacnik Robert , Van Stappen Gilbert , Agh Naser , Horváth Zsόfia 
Published: January 2023

AbstractVery little is known about the feeding of naupliar and juvenile life stages of omnivorous fairy shrimps (Crustacea: Anostraca). Here, we aim to reveal whether the fairy shrimp Branchinecta orientalis is an ontogenetic omnivore and at which age and ontogenetic stage they gain the ability to feed on zooplankton. We assess how food uptake rates change with age until reaching maturity by providing algae (pico- and nanoplanktonic unicellular algae) and zooplankton (rotifers and copepod nauplii) as food in individual experiments. We found that the fairy shrimp B. orientalis started to feed on both types of algal prey immediately after hatching. Nanoplanktonic algae likely represented the most important food source until reaching maturity. Moreover, fairy shrimps started to feed on zooplankton already when they were 7 days old. Slow-moving rotifers gradually gained importance in the fairy shrimp diet with time. Our results reveal an ontogenetic change in the prey spectrum of fairy shrimp. The systematic shift towards omnivory likely affects both phyto- and zooplankton community composition, possibly contributing to temporal changes in food web dynamics in fairy shrimp habitats, and temporary ponds, which may warrant more detailed investigations in future studies.
Clinical Practice Guidelines for the Immunological Management of Chromosome 22q11.2 Deletion Syndrome and Other Defects in Thymic Development
Authors: Mustillo Peter J. , Sullivan Kathleen E. , Chinn Ivan K. , Notarangelo Luigi D. , Haddad Elie , Davies E. Graham , de la Morena Maria Teresa , Hartog Nicholas , Yu Joyce E. , Hernandez-Trujillo Vivian P. , Ip Winnie , Franco Jose , Gambineri Eleonora , Hickey Scott E. , Varga Elizabeth , Markert M. Louise 
Published: January 2023

Abstract Current practices vary widely regarding the immunological work-up and management of patients affected with defects in thymic development (DTD), which include chromosome 22q11.2 microdeletion syndrome (22q11.2del) and other causes of DiGeorge syndrome (DGS) and coloboma, heart defect, atresia choanae, retardation of growth and development, genital hypoplasia, ear anomalies/deafness (CHARGE) syndrome. Practice variations affect the initial and subsequent assessment of immune function, the terminology used to describe the condition and immune status, the accepted criteria for recommending live vaccines, and how often follow-up is needed based on the degree of immune compromise. The lack of consensus and widely varying practices highlight the need to establish updated immunological clinical practice guidelines. These guideline recommendations provide a comprehensive review for immunologists and other clinicians who manage immune aspects of this group of disorders.
Determination of Monosodium Glutamate in Noodles Using a Simple Spectrofluorometric Method based on an Emission Turn-on Approach
Authors: Kamal Amira H. , El-Malla Samah F. , Elattar Rehab H. , Mansour Fotouh R. 
Published: January 2023

Abstract
A simple, fast, and ecofriendly spectrofluorometric method was developed and validated for determination of mono sodium glutamate (MSG). The method depended on the reaction between MSG and iron (III) salicylate based on ligand exchange mechanism. Addition of MSG turned-on the fluorescent response of iron (III) salicylate at λem 411 nm. Reaction conditions including reagent concentration, pH, and time were optimized. The method was validated regarding the ICH guidelines. The method determined MSG within the linearity range of 25—250 µM with a coefficient of determination of 0.9967 and a calculated limit of detection of 1.73 µM. Furthermore, the developed method was successfully applied for the determination of MSG in food preparation (instant noodles). The results were compared to those obtained by a published HPLC method using t-test and F-test at 95% confidence interval; no statistically significant difference was found. Based on the analytical Eco-scale and the green analytical procedure index (GAPI), the developed method was assessed to be greener than the published HPLC method. The developed method offered advantages over other spectrophotometric reported methods and was convenient for routine determination of MSG in foodstuffs.
Quantifying the cost of quality in construction projects: an insight into the base of the iceberg
Authors: Khadim Nouman , Thaheem Muhammad Jamaluddin , Ullah Fahim , Mahmood Muhammad Nateque 
Published: January 2023

AbstractConstruction projects are complex endeavors where achieving higher quality standards is challenging due to the intrinsic difficulties and dynamic quality management processes. Several quality management techniques exist to overcome quality concerns, such as the cost of quality (COQ). However, implementing COQ in building construction is challenging due to the absence of a comprehensive quality cost-capturing system. Several studies have tried to quantify different quality costs but are mainly focused on visible failure cost—the tip of the iceberg while the base of the iceberg has rarely been explored. This study develops and quantifies each component of the visible and hidden quality costs—the base of the iceberg. Accordingly, a modified prevention, appraisal, and failure model is developed and applied to the primary data of 25 building projects. The findings highlight the unfamiliarity and passive attitude of the involved construction firms towards quality, thus, incurring higher failure costs amounting to over 12% of the total project cost. Most of this cost remains hidden as traditional accounting systems cannot capture it. Such costs must be eliminated by implementing COQ systems as utilized in the current study. Further, a quality costing framework is established for building projects and applied to the local construction industry to reduce construction failures and improve the quality performance of building projects.
Water and Environmental Systems Management Under Uncertainty: From Scenario Construction to Robust Solutions and Adaptation
Authors: Cunha Maria da Conceição 
Published: January 2023

AbstractThis paper presents and discusses concepts, models, and methods for defining strategies, plans, and actions to achieve the sustainable development of water and environmental systems in a context of uncertainty. The complexity of such systems, including human and natural landscapes and their interactions, is a tremendous challenge with regard to decision-making processes. The future that is now being designed involves a myriad of uncertainties, climate and non-climate related, that request comprehensive decision frameworks involving multiple processes (institutional, political, social, economic, biophysical, etc.) to prevent disagreements and barriers from impeding the achievement of sustainable decisions. When it comes to assessing responses to future scenarios (or different states of the world), the idea of ​​robustness can include introducing the concept of adaptation. New terms such as “multiple plausible futures” and “deep uncertainty” have been emerging. How past frameworks should give rise to new frameworks so that decisions to be taken on water and environmental systems management and infrastructure planning are adapted to uncertain future conditions are the main issues tackled. The limitations on predicting the future and controlling and managing water and environmental systems mean that policy makers and society in general, especially knowledge-producing centres, need to shift from rhetoric to intervention, to tackle the many changing tendencies of today. Deciding now, at the present time, which has already been the future, the future of the next generations is an intricate and demanding task.
Potential of rainwater harvesting in the retail sector: a case study in Portugal
Authors: Ferreira Ana , Sousa Vitor , Pinheiro Manuel , Meireles Inês , Silva Cristina Matos , Brito Jorge , Mateus Ricardo 
Published: January 2023

Abstract
Water is a crucial resource for life, and it is increasingly scarce in many regions of the globe. In addition, retail water use is responsible for up to 19% of public water globally supplied. Hence, this study has set out to explore the technical and economic feasibility of rainwater harvesting systems as an alternative water source for a retail store located in southern Portugal. Water consumption data from 2018 to 2021 was collected from water bills, placing average monthly water consumption at around 400 m3. Next, rainfall data was collected from the nearest meteorological station, comprising 54 years of daily rainfall data between 1932 and 2008 with an annual average of 685 mm. The simulation of a rainwater harvesting system was performed, resorting to the mass-balance model. The optimal tank size was found to be 100 m3 considering simply the relation with the relative water savings variation on the graph relating the water savings with the tank size. Results show that the simulated rainwater harvesting system would allow saving 32–36% of the water consumed, despite the store’s location in a dry climate, representing a financial gain of €330–372 per month. Findings suggest a substantial potential for the technical and economic feasibility of rainwater systems in retail stores, which makes them relevant solutions to achieve important water-savings in the retail sector, thus positively influencing retailers’ direct water footprint.