bluuebunny/crossref_metadata_2025_split huggingface dataset:
The relationship between neurogenic dysphagia, stroke-associated pneumonia and functional outcome in a cohort of ischemic stroke patients treated with mechanical thrombectomy
Authors: Schumann-Werner Beate , Becker Johanna , Nikoubashman Omid , Wiesmann Martin , Schulz Jörg B. , Reich Arno , Pinho João , Werner Cornelius J. 
Published: August 2023

Abstract
Introduction
Mechanical thrombectomy (MT) is an established treatment approach in acute ischemic stroke patients with large vessel occlusion (LVO). Recent studies suggest that the prevalence of dysphagia and pneumonia risk is increased in this patient population. The aim of this study was to systematically evaluate the prevalence, predictors, and influence of neurogenic dysphagia for 3-month outcome in a large population of patients receiving MT and to elucidate the relationship between dysphagia, stroke-associated pneumonia (SAP) and medium-term functional outcome.

Materials and methods
Data of a prospective collected registry of patients with LVO and MT between 2016 and 2019 were analyzed retrospectively. Binary logistic regression was carried out to determine predictors for dysphagia and 3-month outcome as measured by the modified Rankin Scale, respectively. A mediation analysis was performed to investigate the mediating influence of intercurrent SAP.

Results
A total of 567 patients were included in the study. Mean age was 73.4 years, 47.8% of the patients were female, and median NIHSS was 15.0. The prevalence of dysphagia was 75.1% and 23.3% of all patients developed SAP. In the regression analysis, dysphagia was one of the main independent predictors for poor functional outcome at 3 months. The mediator analysis revealed that the effect of dysphagia on the functional outcome at 3 months was not mediated by the occurrence of SAP.

Discussion
The prevalence of dysphagia is high and exerts both negative short- and medium-term effects on patients with large vessel occlusion who undergo MT.
How do barley plants with impaired photosynthetic light acclimation survive under high-light stress?
Authors: Saeid Nia Monireh , Scholz Louis , Garibay-Hernández Adriana , Mock Hans-Peter , Repnik Urska , Selinski Jennifer , Krupinska Karin , Bilger Wolfgang 
Published: August 2023

Abstract
Main Conclusion
WHIRLY1 deficient barley plants surviving growth at high irradiance displayed increased non-radiative energy dissipation, enhanced contents of zeaxanthin and the flavonoid lutonarin, but no changes in α-tocopherol nor glutathione.

Abstract
Plants are able to acclimate to environmental conditions to optimize their functions. With the exception of obligate shade plants, they can adjust their photosynthetic apparatus and the morphology and anatomy of their leaves to irradiance. Barley (Hordeum vulgare L., cv. Golden Promise) plants with reduced abundance of the protein WHIRLY1 were recently shown to be unable to acclimatise important components of the photosynthetic apparatus to high light. Nevertheless, these plants did not show symptoms of photoinhibition. High-light (HL) grown WHIRLY1 knockdown plants showed clear signs of exposure to excessive irradiance such as a low epoxidation state of the violaxanthin cycle pigments and an early light saturation of electron transport. These responses were underlined by a very large xanthophyll cycle pool size and by an increased number of plastoglobules. Whereas zeaxanthin increased with HL stress, α-tocopherol, which is another lipophilic antioxidant, showed no response to excessive light. Also the content of the hydrophilic antioxidant glutathione showed no increase in W1 plants as compared to the wild type, whereas the flavone lutonarin was induced in W1 plants. HPLC analysis of removed epidermal tissue indicated that the largest part of lutonarin was presumably located in the mesophyll. Since lutonarin is a better antioxidant than saponarin, the major flavone present in barley leaves, it is concluded that lutonarin accumulated as a response to oxidative stress. It is also concluded that zeaxanthin and lutonarin may have served as antioxidants in the WHIRLY1 knockdown plants, contributing to their survival in HL despite their restricted HL acclimation.
Fate of Cryptosporidium and Giardia through conventional and compact drinking water treatment plants
Authors: Moussa Ahmed S. , Ashour Ameen A. , Soliman Mohammad I. , Taha Hoda A. , Al-Herrawy Ahmad Z. , Gad Mahmoud 
Published: August 2023

AbstractOver the past three decades, a notable rise in the occurrence of enteric protozoan pathogens, especially Giardia and Cryptosporidium spp., in drinking water sources has been observed. This rise could be attributed not only to an actual increase in water contamination but also to improvements in detection methods. These waterborne pathogens have played a pivotal role in disease outbreaks and the overall escalation of disease rates in both developed and developing nations worldwide. Consequently, the control of waterborne diseases has become a vital component of public health policies and a primary objective of drinking water treatment plants (DWTPs). Limited studies applied real-time PCR (qPCR) and/or immunofluorescence assay (IFA) for monitoring Giardia and Cryptosporidium spp., particularly in developing countries like Egypt. Water samples from two conventional drinking water treatment plants and two compact units (CUs) were analyzed using both IFA and qPCR methods to detect Giardia and Cryptosporidium. Using qPCR and IFA, the conventional DWTPs showed complete removal of Giardia and Cryptosporidium, whereas Mansheyat Alqanater and Niklah CUs achieved only partial removal. Specifically, Cryptosporidium gene copies removal rates were 33.33% and 60% for Mansheyat Alqanater and Niklah CUs, respectively. Niklah CU also removed 50% of Giardia gene copies, but no Giardia gene copies were removed by Mansheyat Alqanater CU. Using IFA, both Mansheyat Alqanater and Niklah CUs showed a similar removal rate of 50% for Giardia cysts. Additionally, Niklah CU achieved a 50% removal of Cryptosporidium oocysts, whereas Mansheyat Alqanater CU did not show any removal of Cryptosporidium oocysts. Conventional DWTPs were more effective than CUs in removing enteric protozoa. The contamination of drinking water by enteric pathogenic protozoa remains a significant issue globally, leading to increased disease rates. Infectious disease surveillance in drinking water is an important epidemiological tool to monitor the health of a population.
Bewertung einer möglichen Linderung von OSD-spezifischen Symptomen von PURALID® Lipogel in Kombination mit Augenlidhygiene bei Patienten mit anteriorer Blepharitis und konsekutiver Meibom-Drüsen-Dysfunktion
Authors: Laufenböck Christoph 
Published: August 2023

Zusammenfassung

Hintergrund
PURALID® Lipogel (Santen Pharmaceutical Co., Ltd., Osaka, Japan) ist ein neues Produkt zur Behandlung akuter Augenliderkrankungen wie Blepharitis. Trotz seiner mittlerweile häufigen Verwendung in der klinischen Praxis wurde nach Wissen des Autors bisher keine kontrollierte klinische Studie über die Wirksamkeit der oben genannten Therapie publiziert. Das Ziel dieser Studie war es darzustellen, ob es eine bessere symptomlindernde Wirkung mit PURALID® Lipogel bei der Augenlidhygiene im Vergleich zur alleinigen Augenlidhygiene gibt.

Methoden
Es liegt eine nicht verblindete, Single-center-Interventionsstudie vor, die die Augenlidhygiene mit und ohne PURALID® Lipogel zur Behandlung einer Blepharitis von MDD vergleicht. Es wurden 30 Patienten im Zuge der täglichen Sprechstunde rekrutiert. Primäre Endpunkte waren die NIK-BUT („non-invasive break-up-time“) und der OSD(„ocular surface disease“)-Index, sekundäre waren die Meibom-Drüsen-Dysfunktion und die LIPKO(„Lid-Parallel Conjunctival Folds“)-Falten. Es unterzogen sich 15 Patienten (12 Frauen) der Augenlidhygiene in Kombination mit PURALID® Lipogel, während 15 Patienten (13 Frauen) die Augenlidhygiene allein durchführten. Alle Patienten wendeten zusätzlich 3‑mal täglich die Applikation von Cationorm® Augentropfen (Santen Pharmaceutical Co., Ltd.) an. Die Behandlungsdauer erstreckte sich über 2 Monate, die Patienten wurden vor Beginn der Therapie und 2 Monate danach untersucht.

Ergebnisse
Vor den beiden Behandlungsmethoden bestanden keine Unterschiede in oben genannten Parametern, ebenfalls waren Geschlecht und Alter normverteilt. Nach der Behandlung verbesserten sich in beiden Gruppen die subjektiven als auch die objektiven Kriterien, die zusätzliche Anwendung von PURALID® Lipogel erbrachte allerdings keinen Vorteil. Sicherheitsparameter wie Visus und IOD blieben bei allen Patienten unauffällig.

Schlussfolgerungen
Die neben der Anwendung von Tränenersatzmittel und Durchführung einer Lidrandhygiene zusätzliche Verwendung von PURALID® Lipogel erbringt keine Verbesserung der symptomatischen Blepharitis.
Outcome of incisional hernia repair in patients 80 years and older: results from the Herniamed-Registry
Authors: Mehdizadeh-Shrifi A. , Soll C. , Vuille-dit-Bille R. N. , Köckerling F. , Adolf D. , Staerkle R. F. 
Published: August 2023

Abstract
Introduction
More and more often complex abdominal surgeries are performed in the elderly. Together with the ageing population these patients are at risk for incisional hernias. We aimed on assessing outcomes following incisional hernia surgery in patients 80 years and older.

Material and methods
Using the Herniamed-Registry, a prospective multi-institutional database, data on patients undergoing surgery for incisional hernias were retrospectively assessed. 46,040 patients were included and divided by age. Intraoperative-, general-, and postoperative complications as well as 1-year follow-up outcomes were assessed and compared between patients 80 years and older vs younger than 80 years.

Results
Intra- (2.3% vs 1.5%; p < 0.001) and postoperative (8.6% vs 7.2%; p = 0.001) complications, general complications (5.5% vs 3.0%; p < 0.001), as well as reoperations (3.8% vs 3.0%; p = 0.007) were more likely to occur in elderly patients. By contrast, recurrences (3.6% vs 4.5%; p = 0.007), pain at rest (7.3% vs 10.1%; p < 0.001) and on exertion (11.3% vs 18.3%; p < 0.001), as well as pain requiring treatment (5.4% vs 7.7%; p < 0.001) was less likely in the group of patients aged ≥ 80 years.

Conclusion
Incisional hernia repair in patients 80 years and older is associated with a slightly higher complication risk but is quite acceptable and also have improved pain scores. The recurrence difference is also clinically unimportant.
Beach erosion aggravates the drastic decline in marine turtle populations in French Guiana
Authors: Chevallier Damien , Girondot Marc , Péron Christina , Martin Jordan , Bonola Marc , Chevalier Johan , de Thoisy Benoît , Kelle Laurent , Le Maho Yvon , Gardel Antoine , Anthony Edward J. 
Published: August 2023

AbstractYalimapo beach, near the Maroni River estuary in French Guiana, is an important turtle nesting site. The interaction of massive mud banks migrating alongshore from the distant Amazon River with discharge from the Maroni River generates strong beach morpho-sedimentary changes. The eventual degradation of the marine turtle nesting habitats resulting from these changes represents a threat to the offspring, and consequently, to the turtle population. Field operator counts of green and leatherback turtle nests were combined with high-resolution topographic measurements of the beach over four field surveys in 2012 and 2014 to map the topographic modifications susceptible to affect nesting on Yalimapo beach. We assumed that the survival of nests was at stake when the depth of sand between the egg chamber and the topographic surface (i.e. the top) of the beach was < 50 cm, and that beach surface lowering > 10 cm represented unfavourable conditions for nest safety with unequal nest survival across the beach. Erosion of the beach surface exceeding a depth of 50 cm therefore results in nest destruction. Digital elevation models were produced to quantify the topographic modification of nesting on Yalimapo beach and highlight the endangered nesting areas. As the modification of the beach is not linear, some sectors are more eroded than others, resulting in unequal nest survival across the beach. Overall, up to 40% of the nests were presumed destroyed over the 2 years of survey, but true losses would depend on the species and the preferential locations of their nesting habitats. The relatively unfavourable conditions that prevailed during the 2 years of the survey are consistent with persistent erosion of Yalimpao beach since 2011. This ongoing erosion could explain in part the drastic decline of the leatherback turtle population in western French Guiana over the period 2001–2018. The substrate quality and dynamics of the nesting beach in relation to the preferred nesting habitat of each species are therefore critical issues that should be considered in the conservation strategies of marine turtles. The beach nesting conditions of marine turtles in French Guiana, as elsewhere, could be further aggravated in the future by climate change effects, including sea-level rise.
Complete mesocolic excision for right hemicolectomy: an updated systematic review and meta-analysis
Authors: De Lange G. , Davies J. , Toso C. , Meurette G. , Ris F. , Meyer J. 
Published: August 2023

Abstract
Purpose
Complete mesocolic excision improves lymphadenectomy for right hemicolectomy and respects the embryological planes. However, its effect on cancer-free and overall survival is questioned. Therefore, we aimed to determine the potential benefits of the technique by performing a systematic review of the literature and meta-analysis of the available evidence.

Methods
Web of Science, PubMed/Medline, and Embase were searched on February 22, 2023. Original studies on short- and long-term oncological outcomes of adult patients undergoing right hemicolectomy with complete mesocolic excision as a treatment for primary colon cancer were considered for inclusion. Outcomes were extracted and pooled using a model with random effects.

Results
A total of 586 publications were identified through database searching, and 18 from citation searching. Exclusion of 552 articles left 24 articles for inclusion. Meta-analysis showed that complete mesocolic excision increased the lymph node harvest (5 studies, 1479 patients, MD 9.62, 95% CI 5.83–13.41, p > 0.0001, I2 84%), 5-year overall survival (5 studies, 2381 patients, OR 1.88, 95% CI 1.14–3.09, p = 0.01, I2 66%), 5-year disease-free survival (4 studies, 1376 patients, OR 2.21, 95% CI 1.51–3.23, p < 0.0001, I2 0%) and decreased the incidence of local recurrence (4 studies, 818 patients, OR 0.27, 95% CI 0.09–0.79, p = 0.02, I2 0%) when compared to standard right hemicolectomy. Perioperative morbidity was similar between the techniques (8 studies, 3899 patients, OR 1.04, 95% CI 0.89–1.22, p = 0.97, I2 0%).

Conclusion
Meta-analysis of observational and randomised studies showed that right hemicolectomy with complete mesocolic excision for primary right colon cancer improves oncologic results without increasing morbidity/mortality. These results need to be confirmed by high-quality evidence and randomised trials in selected patients to assess who may benefit from the procedure.
A Day on the Nile: Living in a Town in Nubia
Authors: Budka Julia , Ward Chloë , Elkins Carl G. 
Published: August 2023

AbstractAs archaeologists, we are often asked what it was like to live in the past. By blending a fictional narrative with factual archaeological evidence, we offer an interpretation of what a typical day may have been like living at Sai, a town on an island in the River Nile during the second millennium before the common era (BCE), in what is now Sudan. We focus on the question at different levels, thinking about the day-to-day life of the residents of an ancient town, activities that took place, and its broader historical, geographical, and cultural contexts. We also explain how archaeologists work and interpret some of the evidence we discuss, focusing on a range of methods. These include recent advances in virtual 3-D reconstruction, which offer a unique perspective on our interpretation of the past. Many themes covered in this article are highly relevant today and can be linked to several UN Sustainable Development Goals (in particular, 9, 11, and 12). We encourage readers to think about some of the things we discuss in relation to their own lives and experiences and have provided a number of call-out questions in speech bubbles throughout the article to get some of these discussions started.
Large Eddy Simulation of Turbulent Flame Synthesis of Silica Nanoparticles with an Extended Population Balance Model
Authors: Tsagkaridis Malamas , Papadakis George , Jones William P. , Rigopoulos Stelios 
Published: August 2023

AbstractIn the present study, a recently proposed extended population balance equation (PBE) model for aggregation and sintering is incorporated into a large eddy simulation-probability density function (LES-PDF) modelling framework to investigate synthesis of silica nanoparticles in a turbulent diffusion flame. The stochastic field method is employed to solve the LES-PBE-PDF equations, characterising the influence of the unresolved sub-grid scale motions and accounting for the interactions between turbulence, chemistry and particle dynamics. The models for gas-phase chemistry and aerosol dynamics are the same as those recently used by the authors to simulate silica synthesis in a laminar flame (Tsagkaridis et al. in Aerosol Sci Technol 57(4):296–317, 2023). Thus, by retaining the same kinetics without any adjustments in parameters, we focus on the modelling issues arising in silica flame synthesis. The LES results are compared with experimental in-situ small-angle X-ray scattering (SAXS) data from the literature. Good agreement is found between numerical predictions and experimental data for temperature. However, the LES model underestimates the SAXS data for the primary particle diameter by a factor of two. Possible reasons for this discrepancy are discussed in view of the previous laminar flame simulations.
Temperature fluctuation alters immuno-antioxidant response and enhances the susceptibility of Oreochromis niloticus to Aeromonas hydrophila challenge
Authors: Sherif Ahmed H. , Farag Enas A. H. , Mahmoud Abeer E. 
Published: August 2023

AbstractIn Egypt, the temperature of the water fluctuates drastically, reaching a daytime high of 25 °C and a nighttime low of 15 °C, respectively, in the spring and the fall. To understand the mechanism behind fish kill in fish farms, an indoor experiment was conducted wherein 240 Nile tilapia weighing 24 ± 2.5 g were stocked in 12 glass aquaria (20 fish/aquarium). Water temperature was regulated throughout the day at 27 ± 1.5 °C for 12 h from 8:00 a.m. to 8:00 p.m. and at 18 ± 1.5 °C for the remaining 12 h. Fish samples (mucus and tissues) were collected four times with a week interval. Proinflammatory tumor necrosis factor-α and interleukin (IL)-1β were decreased during the 4 weeks, while anti-inflammatory IL-10 was highly upregulated during the first week and then decreased compared to the control. Heat shock protein-70 was significantly raised, but IL-8 was unaffected. The gene expressions of antioxidant enzymes catalase and glutathione peroxidase were markedly elevated in the first week and then decreased linearly until they no longer differed from the control group. Mucus lysozyme significantly decreased in weeks 1 and 2 and then began to increase in weeks 3 and 4. Every week, Aeromonas hydrophila infection resulted in clinical signs that were delayed by over 2 days compared to the control group. The mortality rate increased from 35 to 40%, and bacteria were isolated at a rate of 61.54 to 75% from the surviving fish, compared to a rate of 41.67% in the control group. Fluctuations in water temperature suppress the immunity of Nile tilapia, making them vulnerable to bacterial infection.
Socioeconomic Status, Protective Factors, and Mental Health Problems in Transition from Adolescence to Emerging Adulthood: Results of the Longitudinal BELLA Study
Authors: Maurer Jenny , Meyrose Ann-Katrin , Kaman Anne , Mauz Elvira , Ravens-Sieberer Ulrike , Reiss Franziska 
Published: August 2023

AbstractLower familial socioeconomic status (SES) is associated with more mental health problems in adolescence. The aim of this study was to identify factors that may protect adolescents from families with lower SES from developing mental health problems in emerging adulthood. Data of the population-based longitudinal BELLA study included n = 426 participants aged 13 to 17 years at t0 (2009–2012) and 18 to 24 years at t1 (2014–2017). Hierarchical multiple linear regressions with interaction terms were conducted, examining three selected protective factors (self-efficacy, family climate, and social support). Self-efficacy had a small protective effect for adolescents from families with lower SES for mental health problems in emerging adulthood. However, social support had a small protective effect for adolescents from families with higher SES. No moderating effect was found for family climate. Instead, better family climate in adolescents predicted fewer mental health problems in emerging adulthood with a small effect regardless the SES in adolescence. Results indicate the need for prevention measures for adolescents from families with lower SES for becoming mentally healthy emerging adults.
Climate change amplified the 2009 extreme landslide event in Austria
Authors: Mishra Aditya N. , Maraun Douglas , Knevels Raphael , Truhetz Heimo , Brenning Alexander , Proske Herwig 
Published: August 2023

AbstractLandslides are an important natural hazard in mountainous regions. Given the triggering and preconditioning by meteorological conditions, it is known that landslide risk may change in a warming climate, but whether climate change has already affected individual landslide events is still an open question, partly owing to landslide data limitations and methodological challenges in climate impact attribution. Here, we demonstrate the substantial influence of anthropogenic climate change on a severe event in the southeastern Alpine forelands with some estimated 952 individual landslides in June 2009. Our study is based on conditional event attribution complemented by an assessment of changes in atmospheric circulation. Using this approach, we simulate the meteorological event under observed and a range of counterfactual conditions of no climate change and explicitly predict the landslide occurrence probability for these conditions. We find that up to 10%, i.e., 95 landslides, can be attributed to climate change.
Marginalized iterative ensemble smoothers for data assimilation
Authors: Stordal Andreas S. , Lorentzen Rolf J. , Fossum Kristian 
Published: August 2023

AbstractData assimilation is an important tool in many geophysical applications. One of many key elements of data assimilation algorithms is the measurement error that determines the weighting of the data in the cost function to be minimized. Although the algorithms used for data assimilation treat the measurement uncertainty as known, it is in many cases estimated or set based on some expert opinion. Here we treat the measurement uncertainty as a hyperparameter in a fully Bayesian hierarchical model and derive a new class of iterative ensemble methods for data assimilation where the measurement uncertainty is integrated out. The proposed algorithms are compared with the standard iterative ensemble smoother on a 2D synthetic reservoir model.