bluuebunny/crossref_metadata_2025_split huggingface dataset:
[18F]DCFPyL PET/CT versus [18F]fluoromethylcholine PET/CT in Biochemical Recurrence of Prostate Cancer (PYTHON): a prospective, open label, cross-over, comparative study
Authors: Oprea-Lager Daniela-Elena , Gontier Eric , García-Cañamaque Lina , Gauthé Mathieu , Olivier Pierre , Mitjavila Mercedes , Tamayo Pilar , Robin Philippe , García Vicente Ana Maria , Bouyeure Anne-Charlotte , Bailliez Alban , Rodríguez-Fernández Antonio , Mahmoud Sinan Ben , Vallejo-Casas Juan Antonio , Maksud Philippe , Merlin Charles , Blanc-Durand Paul , Drouet Clément , Tissot Hubert , Vierasu Irina , Vander Borght Thierry , Boos Evelyne , Chossat Florence , Hodolic Marina , Rousseau Caroline 
Published: June 2023

Abstract
Purpose
Primary objective was to compare the per-patient detection rates (DR) of [18F]DCFPyL versus [18F]fluoromethylcholine positron emission tomography/computed tomography (PET/CT), in patients with first prostate cancer (PCa) biochemical recurrence (BCR). Secondary endpoints included safety and impact on patient management (PM).

Methods
This was a prospective, open label, cross-over, comparative study with randomized treatment administration of [18F]DCFPyL (investigational medicinal product) or [18F]fluoromethylcholine (comparator). Men with rising prostate-specific antigen (PSA) after initial curative therapy were enrolled. [18F]DCFPyL and [18F]fluoromethylcholine PET/CTs were performed within a maximum time interval of 12 days. DR was defined as the percentage of positive PET/CT scans identified by 3 central imaging readers. PM was assessed by comparing the proposed pre-PET/CT treatment with the local treatment", defined after considering both PET/CTs.

Results
A total of 205 patients with first BCR after radical prostatectomy (73%; median PSA = 0.46 ng/ml [CI 0.16;27.0]) or radiation therapy (27%; median PSA = 4.23 ng/ml [CI 1.4;98.6]) underwent [18F]DCFPyL- and/or [18F]fluoromethylcholine -PET/CTs, between July and December 2020, at 22 European sites. 201 patients completed the study. The per-patient DR was significantly higher for [18F]DCFPyL- compared to [18F]fluoromethylcholine -PET/CTs (58% (117/201 patients) vs. 40% (81/201 patients), p < 0.0001). DR increased with higher PSA values for both tracers (PSA ≤ 0.5 ng/ml: 26/74 (35%) vs. 22/74 (30%); PSA 0.5 to ≤ 1.0 ng/ml: 17/31 (55%) vs. 10/31 (32%); PSA 1.01 to < 2.0 ng/ml: 13/19 (68%) vs. 6/19 (32%);PSA > 2.0: 50/57 (88%) vs. 39/57 (68%) for [18F]DCFPyL- and [18F]fluoromethylcholine -PET/CT, respectively). [18F]DCFPyL PET/CT had an impact on PM in 44% (90/204) of patients versus 29% (58/202) for [18F]fluoromethylcholine. Overall, no drug-related nor serious adverse events were observed.

Conclusions
The primary endpoint of this study was achieved, confirming a significantly higher detection rate for [18F]DCFPyL compared to [18F]fluoromethylcholine, in men with first BCR of PCa, across a wide PSA range. [18F]DCFPyL was safe and well tolerated.
Efficacy and Safety of Ixazomib Plus Lenalidomide and Dexamethasone Following Injectable PI-Based Therapy in Relapsed/Refractory Multiple Myeloma
Authors: Abe Yu , Sasaki Makoto , Takezako Naoki , Ito Shigeki , Suzuki Kazuhito , Handa Hiroshi , Chou Takaaki , Yoshida Takahiro , Mori Ikuo , Shinozaki Tomohiro , Suzuki Kenshi 
Published: June 2023

Abstract
This nationwide, multicenter, open-label, single-arm study evaluated the efficacy and safety of the oral proteasome inhibitor (PI), ixazomib plus lenalidomide (LEN) and dexamethasone (DEX) (IRd) following injectable PI-based therapy for relapsed/refractory multiple myeloma (RRMM). Of 45 patients enrolled, 36 patients received IRd after achieving at least a minor response to 3 cycles of bortezomib or carfilzomib plus LEN + DEX (VRd, n=6; KRd, n=30). At median follow-up of 20.8 months, the 12-month event-free survival rate (primary endpoint) was 49% (90% CI: 35.9−62.0), counting 11 events of progressive disease/death, 8 dropouts and 4 missing response data. The 12-month progression-free survival (PFS) rate by Kaplan-Meier analysis (dropouts as censoring) was 74% (95% CI: 56−86). Median PFS and time to next treatment (95% CI) were 29.0 (21.3−NE) and 32.3 (14.9−35.4) months, respectively; median OS was not evaluable. The overall response rate was 73%, and 42% of patients had a very good partial response or better. Frequent (≥10% incidence) grade ≥3 treatment emergent adverse events were decreased neutrophil and platelet counts (n=7 [16%] each). Two deaths occurred (one during KRd treatment and one during IRd treatment), both due to pneumonia. IRd following injectable PI-based therapy was tolerable and efficacious in RRMM patients.

Trial registration number
NCT03416374; Date of registration: January 31, 2018
Explicit consistency conditions for fully symmetric cubature on the tetrahedron
Authors: Wang Weizhu , Papanicolopulos Stefanos-Aldo 
Published: June 2023

AbstractA novel fully symmetric basis is derived for the $${S}_4$$

S
4

-invariant polynomial space, by using symmetric polynomials and invariant theory. This new basis enables deriving explicitly the consistency conditions for non-overdeterminedness of moment equations in the case of fully symmetric cubature rules on the tetrahedron. Solving the corresponding linear integer programming problem, optimal and quasi-optimal rule structures are derived. Explicit formulas to calculate the estimated lower bounds in the number of integration points are also given. Additionally, the new basis is of practical interest in calculating specific cubature rules, since it allows decomposing the moment equations into a series of successively independent smaller subsystems, which can be exploited in designing more efficient solution methods. Solving the moment equations analytically we obtain several interesting new results.
Application of Onuma and lattice strain derived methods to calculate missing REE and Ce and Eu anomalies in magmatic zircons
Authors: Carrasco-Godoy Carlos , Campbell Ian H. 
Published: June 2023

AbstractThe shape of chondrite normalized zircon rare earth element (REE) patterns, including the magnitude of the Cerium (Ce) and Europium (Eu) anomalies, provide valuable insights into the magmatic conditions under which a zircon formed. However, lanthanum (La) and praseodymium (Pr), which are essential for the calculation of Ce anomalies, are often present at concentrations close to or below the detection limit of most analytical methods. We propose two new methods to calculate missing REE, based on Onuma diagrams (Chondrite-Onuma) and the lattice strain theory (Chondrite-Lattice), but using chondrite normalized values instead of partition coefficients. We compiled a dataset of ~ 1500 zircons with known REE + Y concentrations and used it to test and calibrate these methods and demonstrate that they are more accurate than other previously published models, with the Chondrite-Onuma method performing better than the Chondrite-Lattice method. These methods require analyses of as few as five REEs to impute the missing REE data or to estimate La and Pr concentrations or Ce anomalies in magmatic zircons, which allows a reduction in the number of REE analysed, where desirable, or to impute missing REEs in legacy data. The imputeREE package for the R programming language was written with a set of tools to apply these methods. A companion app is available to calculate missing REE and Ce and Eu anomalies.
Einflüsse von Kreislaufwirtschaftsmaßnahmen auf Ressourcennutzung und Dekarbonisierung in der Stahl- und Zementindustrie
Authors: Haslauer Peter , Pomberger Roland , Nigl Thomas , Rahnama Mobarakeh Maedeh , Lachner Elisabeth , Kienberger Thomas 
Published: June 2023

ZusammenfassungEine verstärkte Kreislaufwirtschaft ist eine von mehreren Maßnahmen zur Dekarbonisierung industrieller Produktionsprozesse. Insbesondere die energieintensive Grundstoffindustrie hat in der Schließung von Stoffkreisläufen erhebliche Potenziale zur Reduktion von Treibhausgas-Emissionen und Steigerung der Ressourceneffizienz. Eine Analyse des Status Quo zeigt, dass die österreichische Eisen- und Stahlindustrie sowie die Zementindustrie bereits Vorreiter in Kreislaufwirtschaft und der emissionsarmen Produktion in Europa sind. In diesem Artikel werden weitere Potenziale aufgezeigt und insbesondere branchenübergreifende Ansätze zum Schließen von Stoffkreisläufen betrachtet.
Länderübergreifende Problemanalyse und Optimierung des Sedimentmonitorings an der österreichisch-slowakisch-ungarischen Donau im Rahmen der EFRE-Projekte SEDDON II und DREAM SK-AT
Authors: Pessenlehner Sebastian , Liedermann Marcel , Gmeiner Philipp , Haimann Marlene , Glas Martin , Dömötör Szilveszter , Pomázi Flóra , Baranya Sándor , Mravcová Katarína , Holubová Katarína , Habersack Helmut 
Published: June 2023

ZusammenfassungDie Donau und die sie umgebende Landschaft liegen heute im Bereich verschiedener Interessen wie Hochwasserschutz, Wasserkraft, Schifffahrt und Ökologie. Aufgrund dieser Tatsache ist das ehemals ungezähmte und wilde Flusssystem seit Ende des 19. Jahrhunderts mit einer Vielzahl anthropogener Veränderungen konfrontiert, die vielfältige hydromorphologische Auswirkungen zur Folge haben. Zusätzlich führen – trotz bereits umgesetzter Renaturierungsprojekte und teilweise adaptiertem Sedimentmanagement – Einengung durch Regulierungen sowie Beeinflussungen des Sedimenthaushalts wie Rückhalt im Einzugsgebiet und Unterbrechung des Sedimentkontinuums, zu sedimentbezogenen Problemen entlang der Donau. Daraus ergibt sich auch die Notwendigkeit, den Sedimenttransport an der Donau länderübergreifend zu untersuchen.Im Rahmen der EFRE-finanzierten EU-Projekte „Sedimentforschung und -management an der Donau II“ (SEDDON II) und „Forschung und Management an der Donau in der Slowakei und in Österreich“ (DREAM SK-AT) wurde daher eine länderübergreifende Analyse der aktuellen sedimentbezogenen Probleme in drei Projektabschnitten in Österreich, der Slowakei und Ungarn durchgeführt, um die Grundlage für ein gemeinsames Sedimentmanagement zu schaffen. Neben der Analyse der sedimentrelevanten Probleme bildet ein kontinuierliches und einheitliches Monitoringsystem für Geschiebe und Schwebstoff die Basis für die Umsetzung nachhaltiger Maßnahmen im Bereich Flussbau. Durch die Kooperation im Fließgewässermonitoring konnten neben der Implementierung neuer Messstationen an der ungarischen und slowakischen Donau umfangreiche Messreihen zur optimierten Berechnung des Sedimenttransports durchgeführt werden. Die dadurch erhaltenen Daten stellen nicht nur wichtige Erkenntnisse für ein besseres Prozessverständnis dar, darüber hinaus dienen sie auch als Grundlage für numerische Modellierung und physikalische Modellversuche zur Entwicklung und Optimierung von flussbaulichen Maßnahmen, die die vielfältigen Probleme der verschiedenen Interessensgruppen adressieren und negative Auswirkungen in Flusssysteme kompensieren sollen.
Besseres Verständnis von Geschiebetransportprozessen durch integratives Monitoring
Authors: Rindler Rolf , Schwarz Sabrina , Lammer Andrea , Shire-Peterlechner Dorian , Habersack Helmut 
Published: June 2023

ZusammenfassungGeschiebe formt unsere Flüsse, das Flussbett und die Ufer. Es werden ganze Landschaften geprägt, es dient als Lebensraum für viele Tier- und Pflanzenarten. Der Feststoffhaushalt unserer Flüsse wird durch anthropogene Eingriffe stark beeinträchtigt. Die Folgen für die Fließgewässer sind beträchtlich und betreffen unterschiedlichste Bereiche. Speicherbauwerke, die für eine lange Lebensdauer geplant wurden, sind zunehmend einer Verlandung ausgesetzt. Effekte aus Geschieberückhalt, wie die Errichtung von Geschiebesperren, Wehren und Stauräumen und eine Erhöhung der Transportkapazität durch Flussregulierungen zum Hochwasserschutz und Nutzung der Flüsse als Wasserstraße führen in vielen Flüssen zu einem Geschiebedefizit mit den bekannten negativen Folgen für Ökologie und (Schutz‑)Wasserbau.Intensives und gut konzipiertes Feststoffmanagement ist erforderlich, um uns den Herausforderungen, vor denen unsere Flüsse und wir heute und zukünftig stehen, zu stellen. Neben einem großen Erfahrungs- und Wissensschatz bilden hierbei Naturmessdaten und erweitertes Prozessverständnis über Sedimenteinträge, Transportprozesse wie örtliche und zeitliche Verteilung eine grundlegende Voraussetzung für die Entwicklung von Transportformeln und nachhaltige und resiliente Maßnahmen im Wasserbau. Dieser Artikel gibt einen Einblick über die Erkenntnisse, die durch Geschiebelangzeitmonitoring gewonnen werden können.
Glucose variability: a new risk factor for cardiovascular disease
Authors: Belli Martina , Bellia Alfonso , Sergi Domenico , Barone Lucy , Lauro Davide , Barillà Francesco 
Published: June 2023

Abstract
Aims and data synthesis
Glucose variability (GV) is increasingly considered an additional index of glycemic control. Growing evidence indicates that GV is associated with diabetic vascular complications, thus being a relevant point to address in diabetes management. GV can be measured using various parameters, but to date, a gold standard has not been identified. This underscores the need for further studies in this field also to identify the optimal treatment.

Conclusions
We reviewed the definition of GV, the pathogenetic mechanisms of atherosclerosis, and its relationship with diabetic complications.
Non-solvable Groups whose Character Degree Graph has a Cut-Vertex. I
Authors: Dolfi Silvio , Pacifici Emanuele , Sanus Lucia , Sotomayor Victor 
Published: June 2023

AbstractLet G be a finite group. Denoting by $$\textrm{cd}(G)$$

cd
(
G
)

the set of degrees of the irreducible complex characters of G, we consider the character degree graph of G: this is the (simple undirected) graph whose vertices are the prime divisors of the numbers in $$\textrm{cd}(G)$$

cd
(
G
)

, and two distinct vertices p, q are adjacent if and only if pq divides some number in $$\textrm{cd}(G)$$

cd
(
G
)

. In the series of three papers starting with the present one, we analyze the structure of the finite non-solvable groups whose character degree graph possesses a cut-vertex, i.e. a vertex whose removal increases the number of connected components of the graph.
Public face mask use during the COVID-19 pandemic in Auckland, New Zealand
Authors: Zagreanu Claudia , Morse Zac 
Published: June 2023

Abstract
Aim
Public health officials recommended the use of face masks by the population to combat the transmission of COVID-19. Studies on self-reported behaviour are a poor substitute for assessing adherence to government recommendations. This study aimed to determine the percentage of pedestrians wearing masks in the Central Business District (CBD) and a suburb of Auckland, New Zealand (NZ).

Methods
This direct observational study of pedestrians crossing two busy intersections occurred between 22 August 2020 and 7 March 2022. Data collection occurred at three separate times during the day, in the morning (from 8 to 9 am), noon (from 12 to 1 pm) and afternoon (from 4 to 5 pm) for precisely one hour each time.

Results
Over 12 days of COVID alert level restrictions, we observed 30,855 pedestrians. Overall, 57.9% of pedestrians wore a mask outdoors. Masks-wearing was significantly higher in the CBD (64.0%) than in the suburb (38.7%), p < 0.001. Masks use was lower in the morning (51.1%) than at noon (56.1%) or afternoon (62.7%), p < 0.001, both in the CBD and the suburb.

Conclusion
This was the first observational study in NZ examining the public’s mask use during the COVID-19 pandemic. From our observations, there may be opportunities for improvement in public face mask use rates to decrease the spread of COVID-19 in the population. In addition, our findings can inform national and international public health agencies about face mask uptake in public.
Plasma cell-free tumor DNA, PIK3CA and TP53 mutations predicted inferior endocrine-based treatment outcome in endocrine receptor-positive metastatic breast cancer
Authors: Chen Tom Wei-Wu , Hsiao Wen , Dai Ming-Shen , Lin Ching-Hung , Chang Dwan-Ying , Chen I-Chun , Wang Ming-Yang , Chang Shu-Han , Huang Shu-Min , Cheng Ann-Lii , Wu Ko-Wen , Tan Kien Thiam , Lu Yen-Shen 
Published: June 2023

AbstractPurposeHow to factor both tumor burden and oncogenic genomic mutations as variables to predict the outcome of endocrine-based therapy (ET) in ER-positive/HER2-negative metastatic breast cancer patients (MBC) remains to be explored.MethodBlood samples prospectively collected from 163 ER-positive/HER2-negative female MBC patients, before ET, were used for cell-free tumor DNA (cfDNA) analysis. cfDNA was subjected to next-generation sequencing (NGS) to interrogate oncogenicPIK3CAhotspot andTP53DNA-binding domain (DBD) mutations, including single nucleotide variants (SNVs) or small insertions and deletions (InDels). The variant calling threshold was set at 0.5%. Progression-free survival (PFS) was measured from the start of the ET treatment to the time of disease progression of the same treatment regimen.ResultsOverall, the median PFS was 8.3 months (95% CI 5.7–11.1 months). The median cfDNA was 38.5 ng (range 4.4–1935 ng). The proportion of patients withPIK3CAandTP53alterations were 25.1 and 15.3%, respectively. Patients with high total cfDNA (HR 1.74,p = 0.003),PIK3CAmutation (HR 1.74,p = 0.007), andTP53mutation (HR 1.64,p = 0.047) in liquid biopsy conferred worse outcome after ET. Even for patients with low tumor burden, the detrimental effect ofPIK3CAorTP53mutation remained significant (p < 0.001). For patients with eitherPIK3CA(p < 0.001) orTP53mutation (p = 0.004), there was significant positive correlation between allele frequency (AF) and total cfDNA.ConclusionAfter adjustment of cfDNA level,PIK3CAandTP53mutations observed in liquid biopsy exerted detrimental effects on the outcome of ET-based regimens. The AF ofPIK3CAorTP53may be a surrogate marker for PFS.
Valve disease in cardiac amyloidosis: an echocardiographic score
Authors: Aimo Alberto , Fabiani Iacopo , Maccarana Agnese , Vergaro Giuseppe , Chubuchny Vladyslav , Pasanisi Emilio Maria , Petersen Christina , Poggianti Elisa , Giannoni Alberto , Spini Valentina , Taddei Claudia , Castiglione Vincenzo , Passino Claudio , Fontana Marianna , Emdin Michele , Venneri Lucia 
Published: June 2023

AbstractCardiac amyloidosis (CA) may affect all cardiac structures, including the valves. From 423 patients undergoing a diagnostic workup for CA we selected 2 samples of 20 patients with amyloid transthyretin (ATTR-) or light-chain (AL-) CA, and age- and sex-matched controls. We chose 31 echocardiographic items related to the mitral, aortic and tricuspid valves, giving a value of 1 to each abnormal item. Patients with ATTR–CA displayed more often a shortened/hidden and restricted posterior mitral valve leaflet (PMVL), thickened mitral chordae tendineae and aortic stenosis than those with AL–CA, and less frequent PMVL calcification than matched controls. Score values were 15.8 (13.6–17.4) in ATTR–CA, 11.0 (9.3–14.9) in AL–CA, 12.8 (11.1–14.4) in ATTR–CA controls, and 11.0 (9.1–13.0) in AL–CA controls (p = 0.004 for ATTR- vs. AL–CA, 0.009 for ATTR–CA vs. their controls, and 0.461 for AL–CA vs. controls). Area under the curve values to diagnose ATTR–CA were 0.782 in patients with ATTR–CA or matched controls, and 0.773 in patients with LV hypertrophy. Patients with ATTR–CA have a prominent impairment of mitral valve structure and function, and higher score values. The valve score may help identify patients with ATTR–CA among patients with CA or unexplained hypertrophy.
Gender Differences in School Effects on Adolescent Life Satisfaction: Exploring Cross-National Variation
Authors: Marquez Jose 
Published: June 2023

Abstract
Background
Levels and drivers of adolescent life satisfaction (LS) vary across nations. School is known to be an important aspect of life affecting adolescent LS, but there are gender differences in how schools may influence LS. However, little is known about how these gender differences vary across countries.

Objective
A series of statistical analyses (bivariate associations, multilevel regression, and Blinder-Oaxaca decomposition analyses) using PISA 2015 data on 15-year-old students in 33 countries.

Method
A series of statistical analyses (bivariate associations, multilevel regression, and Blinder-Oaxaca decomposition analyses) using PISA 2015 data on 15-year-old students in 33 countries.

Results
Girls report lower overall LS than boys on average in all the countries studied. Various cross-national patterns emerge regarding the role of schools. Although school is a life domain in which experiences related to overall LS tend to be more negative among boys than among girls (mainly via bullying and relationships with teachers), the opposite is observed for a few school-related factors (notably school anxiety). Furthermore, in some countries, the gender gap in overall LS varies across schools, which suggests that schools would play an important role in shaping students’ LS in different ways for girls and boys. Despite some cross-national patterns, substantial cross-country variation is also observed.

Conclusion
The study of adolescent LS in schools may benefit from more nuanced approaches that account for cross-cultural differences in how schools may promote the subjective well-being of girls and boys in different ways.
Assessment of soil- and water-related ecosystem services with coupling the factors of climate and land-use change (Example of the Nitra region, Slovakia)
Authors: Adelisardou Fatemeh , Mederly Peter , Minkina Tatian 
Published: June 2023

AbstractClimate and land use change can profoundly impact the provision of ecosystem services (ES) over time, particularly in the landscape of open fields along with growing urbanization and rising demand for space, food and energy. Policymakers are keen on knowing the combined effects of climate and land use change on ESs as a critical issue in human well-being. However, deep knowledge of how to identify these relationships is still lacking. This research aims to undertake a comprehensive assessment of soil- and water-related ES, and improvement in understanding how they are affected by climate and land use change. We applied the Integrated Valuation of Ecosystem Services and Trade-offs model for four ES (soil retention, nutrient delivery ratio, carbon storage, and water yield) for the years 2000 and 2018 in the Nitra region, Slovakia. We investigated the spatial and temporal changes in ES provision and determined the hotspots and coldspots of multiple ES. We found that soil retention, water yield, and carbon storage display a rising trend while the nutrient delivery ratio showed a decreasing trend over the past 18 years. Although all the mentioned services mainly attributed to land use change, the relative contribution of climate change was not deniable. Forests in the north and east and distributed urbanization and agriculture are the hotspots and coldspots for all ESs, respectively. Our results, in terms of determining the relative importance of land use and climate change and identifying the sensitive areas of ES provision, provide a scientific basis for ecosystem conservation and management priority setting at the local and regional levels.