bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predictive value of controlling nutritional status score in postoperative recurrence and metastasis of breast cancer patients with HER2-low expression
Authors: Li Yue , Zhang Yue , Zhou Zhaoyue , Shang Lingmin , Huang Yuanxi , Lu Xiangshi , Cheng Shaoqiang 
Published: July 2023

BackgroundTo investigate the predictive value of controlling nutritional status (CONUT) score in Postoperative Recurrence and Metastasis of Breast Cancer Patients with HER2-Low Expression.MethodsThe clinicopathological data of 697 female breast cancer patients who pathology confirmed invasive ductal carcinoma and surgery in Harbin Medical University Tumor Hospital from January 2014 to January 2017 were retrospectively analyzed. The relationship between CONUT score and various clinicopathological factors as well as prognosis was evaluated.ResultsBased on the cut-off point of ROC curve, compared with the low CONUT score group, the high CONUT score group had worse 5-year RFS. In subgroup analysis, compared with the low CONUT group, the high CONUT group had worse prognosis at different TNM stages. Univariate and multivariate results showed that the low CONUT score group had better overall survival and recurrence-free survival than the high CONUT group.ConclusionCONUT score is an independent predictor of postoperative recurrence and metastasis in HER2-low breast cancer patients. It is may be used as an effective tool to predict the recurrence and metastasis of HER2-low breast cancer.
Pembrolizumab plus lenvatinib in advanced endometrial cancer: case report and systematic review of lung toxicity
Authors: Staropoli Nicoletta , Salvino Angela , Falcone Federica , Farenza Valentina , Costa Martina , Rossini Giacomo , Manti Francesco , Crispino Antonella , Riillo Caterina , Ciliberto Domenico , Arbitrio Mariamena , Tassone Pierfrancesco , Tagliaferri Pierosandro 
Published: July 2023

BackgroundThe optimal strategy for the treatment of recurrent and/or advanced endometrial cancer is still undefined. Recently, despite the lack of any predictive biomarker, the combination of pembrolizumab with lenvatinib has improved survival outcomes. We here report the long-term management of lung toxicity in a patient with endometrial cancer, and we critically review the current therapeutic options for this disease.ResultsA patient with heavily pretreated endometrial cancer took pembrolizumab plus lenvatinib for 1 year, achieving a persistent partial response with a time to treatment failure of 18 months, despite relevant lung toxicity that did not affect the remarkable overall clinical benefit. A systematic review of this combination underlines the efficacy outcome despite toxicity. Interestingly, the literature review on lung toxicity suggested the role of anti-angiogenetic agents in the pathogenesis of lung cavitation, probably related to direct treatment activity, and disclosed a potential radiological sign predictive of the activity of anti-angiogenetic agents.ConclusionWe underline the efficacy of pembrolizumab plus lenvatinib in the current treatment landscape of endometrial cancer, underscoring the relevance of a correct management of toxicity.
Diagnostic experience of intravenous leiomyomatosis with emphasis on conventional ultrasonography imaging: a single-center study
Authors: Ge Zhitong , Wang Yahong , Wang Ying , Li Wanying , Yang Xiao , Li Jianchu , Wang Hongyan 
Published: July 2023

ObjectiveIntravenous leiomyomatosis (IVL) is a rare and aggressive tumor type that has the potential to extend into the inferior vena cava (IVC) and is susceptible to be misdiagnosed and neglected. Despite its clinical significance, there is a paucity of research that has focused on the specific manifestations of IVL on ultrasonography. Therefore, this study aims to systematically analyze the specific ultrasound features of IVL and augment its diagnostic accuracy.Materials and methodProspective inclusion was granted to patients admitted to our hospital between December 2016 and March 2021 for an IVC-occupying lesion. Multi-modal ultrasonography, encompassing gray-scale and color Doppler, was conducted. Lesions were categorized as IVL or non-IVL based on pathological or follow-up data. Two ultrasound sonographers with over 5 years of experience read and recorded ultrasound data for all lesions, which were subsequently comparatively analyzed to identify specific signs of IVL.ResultsA total of 284 patients diagnosed with IVC-occupying lesions were included in the study. The lesion types comprised of IVL (n=67, 23.6%), IVC thrombus (n=135, 47.5%), tumor thrombus of renal carcinoma involving the IVC (n=35, 12.4%), tumor thrombus of liver carcinoma involving the IVC (n=24, 8.5%), leiomyosarcoma of the IVC (n=14, 4.9%), and tumor thrombus of adrenocortical adenocarcinoma (n=9, 4.1%). The presence of “sieve hole” and “multi-track” signs was observed in 20 IVL lesions under the grey-scale modality, while both signs were absent in the non-IVL group (P&lt;0.01). The study found no statistically significant differences in the presentation of “sieve hole” and “multi-track” signs under the grey-scale and color Doppler modalities in cases of intravascular lithotripsy (IVL) (P&gt;0.05). Using these two signs as diagnostic criteria for IVL, the sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), miss rate, misdiagnosis rate, and accuracy were determined to be 29.9%, 100%, 100%, 82.2%, 70.1%, 0, and 83.5%, respectively (AUC ROC=0.649; 95%CI: 0.537-0.761).ConclusionIVL exhibits distinct ultrasound presentations, including “sieve hole” and “multi-track” signs, which demonstrate high specificity and accuracy as diagnostic indicators. Furthermore, these signs are corroborated by pathological evidence and effectively distinguish IVL from other lesions occupying the IVC.
Theoretical design for covering Engeletin with functionalized nanostructure-lipid carriers as neuroprotective agents against Huntington’s disease via the nasal-brain route
Authors: Smriti  , Singla Madhav , Gupta Saurabh , Porwal Omji , Nasser Binjawhar Dalal , Sayed Amany A. , Mittal Pooja , El-Demerdash Fatma M. , Algahtani Mohammad , Singh Sachin Kumar , Dua Kamal , Gupta Gaurav , Bawa Puneet , Altyar Ahmed E. , Abdel-Daim Mohamed M. 
Published: July 2023

Objective:To propose a theoretical formulation of engeletin-nanostructured lipid nanocarriers for improved delivery and increased bioavailability in treating Huntington’s disease (HD).Methods:We conducted a literature review of the pathophysiology of HD and the limitations of currently available medications. We also reviewed the potential therapeutic benefits of engeletin, a flavanol glycoside, in treating HD through the Keap1/nrf2 pathway. We then proposed a theoretical formulation of engeletin-nanostructured lipid nanocarriers for improved delivery across the blood-brain barrier (BBB) and increased bioavailability.Results:HD is an autosomal dominant neurological illness caused by a repetition of the cytosine-adenine-guanine trinucleotide, producing a mutant protein called Huntingtin, which degenerates the brain’s motor and cognitive functions. Excitotoxicity, mitochondrial dysfunction, oxidative stress, elevated concentration of ROS and RNS, neuroinflammation, and protein aggregation significantly impact HD development. Current therapeutic medications can postpone HD symptoms but have long-term adverse effects when used regularly. Herbal medications such as engeletin have drawn attention due to their minimal side effects. Engeletin has been shown to reduce mitochondrial dysfunction and suppress inflammation through the Keap1/NRF2 pathway. However, its limited solubility and permeability hinder it from reaching the target site. A theoretical formulation of engeletin-nanostructured lipid nanocarriers may allow for free transit over the BBB due to offering a similar composition to the natural lipids present in the body a lipid solubility and increase bioavailability, potentially leading to a cure or prevention of HD.Conclusion:The theoretical formulation of engeletin-nanostructured lipid nanocarriers has the potential to improve delivery and increase the bioavailability of engeletin in the treatment of HD, which may lead to a cure or prevention of this fatal illness.
Prediction of guidewire-induced aortic deformations during EVAR: a finite element and in vitro study
Authors: Emendi Monica , Støverud Karen H. , Tangen Geir A. , Ulsaker Håvard , Manstad-H Frode , Di Giovanni Pierluigi , Dahl Sigrid K. , Langø Thomas , Prot Victorien 
Published: July 2023

Introduction and aims: During an Endovascular Aneurysm Repair (EVAR) procedure a stiff guidewire is inserted from the iliac arteries. This induces significant deformations on the vasculature, thus, affecting the pre-operative planning, and the accuracy of image fusion. The aim of the present work is to predict the guidewire induced deformations using a finite element approach validated through experiments with patient-specific additive manufactured models. The numerical approach herein developed could improve the pre-operative planning and the intra-operative navigation.Material and methods: The physical models used for the experiments in the hybrid operating room, were manufactured from the segmentations of pre-operative Computed Tomography (CT) angiographies. The finite element analyses (FEA) were performed with LS-DYNA Explicit. The material properties used in finite element analyses were obtained by uniaxial tensile tests. The experimental deformed configurations of the aorta were compared to those obtained from FEA. Three models, obtained from Computed Tomography acquisitions, were investigated in the present work: A) without intraluminal thrombus (ILT), B) with ILT, C) with ILT and calcifications.Results and discussion: A good agreement was found between the experimental and the computational studies. The average error between the final in vitro vs. in silico aortic configurations, i.e., when the guidewire is fully inserted, are equal to 1.17, 1.22 and 1.40 mm, respectively, for Models A, B and C. The increasing trend in values of deformations from Model A to Model C was noticed both experimentally and numerically. The presented validated computational approach in combination with a tracking technology of the endovascular devices may be used to obtain the intra-operative configuration of the vessels and devices prior to the procedure, thus limiting the radiation exposure and the contrast agent dose.
Biocompatibility of Membranes Based on a Mixture of Chitosan and Lythri herba Aqueous Extract
Authors: Iancu Irina Mihaela , Schröder Verginica , Apetroaei Manuela-Rossemary , Crețu Ruxandra Mihaela , Mireșan Horațiu , Honcea Adina , Iancu Valeriu , Bucur Laura Adriana , Mitea Gabriela , Atodiresei-Pavalache Georgiana 
Published: July 2023

In the current context of concern for the improvement and protection of environmental conditions, emphasis is placed on the provision of non-toxic, eco-friendly, renewable biomaterials to replace established chemical substances. Lythri herba is the aerial part of the plant species Lythrum salicaria L., known in the scientific literature especially for its content of tannins and total polyphenols, which highlight its antioxidant, hemostatic, antibacterial and antidiarrheal properties. Chitosan is a biopolymer widely used in industry and medicine due to its abundance in nature, its biodegradability, lack of toxicity and the ease with which it can be transformed into several basic forms (hydrogel, membrane, sponge). The aqueous solutions and membranes obtained in this study by merging these two natural resources were biologically tested in terms of genotoxicity (SOS-Chromo assay), hemolytic activity, thrombin generation activity and bacterial adhesion to reveal outwardly the lack of these properties and their use for medical purposes. The results of the current study attest to the absence of mutagenic and slight hemolyzing properties, thus supporting the possibility of using this extract and membrane in medical and pharmaceutical therapeutic practice. The surface parameters of membranes were examined and important influences at thrombin activity were found. Also, bacterial adhesion results showed a correlation between Lythri herba and chitosan concentrations and membranes’ appearances (swelling, stability). The results show that the membranes could be a promising material for biomedical applications.
Effect of Climate and Competition on Radial Growth of Pinus sylvestris var. mongolica Forest in Hulunbuir Sandy Land of Inner Mongolia, China
Authors: Wen Shuo , Shi Zhongjie , Zhang Xiao , Pan Leilei , Kwon Semyung , Li Yuheng , Yang Xiaohui , Li Hanzhi 
Published: July 2023

(1) Background: The forest of Pinus sylvestris var. mongolica is an important semi-arid ecosystem in Hulunbuir sandy land that plays a key role in the carbon cycle and wind erosion control. It is crucial to explore the main factors affecting the radial growth of trees of P. sylvestris var. mongolica. (2) Methods: The study established the tree-ring chronology of P. sylvestris var. mongolica and analyzed the relationships among the radial growth, competition index, and climate variables using correlation analysis and a linear mixed effect model to explore the influence of competition and climate on radial growth of P. sylvestris var. mongolica. (3) Results: The results indicated that tree growth is mainly affected by the maximum average temperature (Tmax) and precipitation in June and July of the current year and that tree growth significantly decreased with increasing competition pressure. Analysis of the linear mixed effect model showed that tree age, competition intensity, self-calibrating Palmer drought severity index (scPDSI) from May to July, and vapor pressure deficit (VPD) have a significant impact on radial growth. (4) Conclusions: The competition plays a dominant role in radial growth of P. sylvestris var. mongolica compared to climate factors. This study helps to understand the growth mechanism of P. sylvestris var. mongolica forests under climate change and provides a scientific basis for effective management of semi-arid forests.
Improvement of piezoelectric properties of epitaxial (K,Na)NbO3 thin films grown on Si substrates
Authors: Tanaka Kiyotaka , Ogawa Rei , Kweon Sang Hyo , Tan Goon , Kanno Isaku 
Published: July 2023

Abstract
Lead-free epitaxial (K0.47Na0.53)NbO3 (KNN) thin films were fabricated on (001)SrRuO3/Pt/ZrO2/Si substrates by RF magnetron sputtering at 650 °C and were post-annealed at the same 650 °C by a rapid thermal annealing (RTA) process. The crystal structure of epitaxial KNN thin films were changed by RTA, i.e. the lattice parameter c in the out-of-plane direction decreased instead of an increase of the parameter a in the in-plane direction. The displacement–electric field curve of the RTA-annealed KNN thin films was symmetrical and the shift of the polarization reversal field was smaller than in the KNN thin films annealed by a conventional furnace. This means that RTA is effective in compensating for oxygen vacancies as well as suppressing the generation of A-site vacancies at the interface between the thin film and the substrate. The converse piezoelectric coefficient ∣e
31,f
∣ of the epitaxial KNN/Si unimorph cantilever was found to improve by up to 7.7 C m−2 due to the decrease in defect density resulting from RTA.
Self-organized Ge1−x
Sn
x
quantum dots formed on insulators and their room temperature photoluminescence
Authors: Hashimoto Kaoru , Shibayama Shigehisa , Asaka Koji , Sakashita Mitsuo , Kurosawa Masashi , Nakatsuka Osamu 
Published: July 2023

Abstract
In this study, we examined the self-organized formation of Ge1−x
Sn
x
quantum dots (QDs) on insulators based on a simple sputtering process and considered their luminescence properties. First, we systematically discussed the control factors in the self-organized formation of Ge1−x
Sn
x
QDs; the introduced Sn content and the deposition temperature should be related to the surface-migration of Sn atoms. Under sufficiently controlled conditions, we achieved the self-organized formation of Ge1−x
Sn
x
QDs surrounded by amorphous-like shells with a dot size of 9.3 nm, Sn content of 19% ± 10%, and dot density of 1.5 × 1011 cm−2 and they showed a 2.0 μm photoluminescence peak at RT. Furthermore, the formation of multilayered Ge1−x
Sn
x
QDs structures was demonstrated, and they exhibited excellent thermal stability up to 400 °C while maintaining a dot-like morphology without causing the agglomeration. Therefore, the self-organized formation of Ge1−x
Sn
x
QDs is useful for realizing light-emitting devices for optical interconnects.
Acoustic metalens with switchable and sharp focusing
Authors: Mei Jun , Fan Lijuan , Hong Xiaobin 
Published: July 2023

Abstract
Sharp and tunable focusing functionality is highly desired in various acoustic application fields. Here, we propose a simply structured metalens for water-borne sounds with a switchable focusing functionality. Each meta-atom in the lens is composed of two elliptical iron cylinders, and is smartly designed so that it can redirect a normally incident plane wave toward the same focal spot. A switchable focusing functionality between a transmissive lens and a reflective one can be achieved by simply rotating the elliptical cylinders. Furthermore, a sharp focusing effect is obtained with a high-intensity concentration ratio along both transverse and longitudinal directions.
أنواع الترب وخصائصها الفيزيائية والكيميائية في حوض وادي العاذر
Authors: ميرفت عبد المجيد علي  
Published: July 2023

تقع منطقة الدراسة في وسط الصحراء الغربية ، إذ انه أحد أحواض المنطقة الغربية وتبلغ مساحته (40.031كم2) وتهدف الدراسة إلى التعرف على تربة حوض وادي المعاذر، من خلال الدراسة اتضح أن تربة هذا الحوض من الترب الحديثة التكوين، إذ أن نشوءها جاء متزامناً مع نشوء المنخفضات التي ملأت قيعانها الترسبات المحمولة بواسطة الوديان والمسيلات المائية الحاملة للمواد الرملية والغرينية والطينية من المكاشف الصخرية المجاورة لها، إذ أن تراكم الترسبات على نحو مستمر بمساعدة الامطار في موسم سقوطها جعل من ترب حوض وادي المعاذر حديثة التكوين والدليل على ذلك أن مقاطع التربة التي حفرت اثناء الدراسة دللت على أن عينات التربة المأخوذة اثناء الدراسة الميدانية تتميز بوجود طبقات رسوبية ناشئة من فتات الصخور المنقولة.
وبما أن الترب تكتسب صفاتها من المواد الاولية التي اشتقت منها لذلك فهي تختلف من مكان لاخر تبعاً لاختلاف العناصر المعدنية المكونة لها ([1]).

([1]) علي احمد عطيوي ومزيد مجيد عبد وسامي عبد الصاحب، مبادئ استصلاح الاراضي، مطبعة دار الحكمة للطباعة والنشر، الموصل، 1990، ص57.
Pengaruh Pemberian Terapi Murotal Terhadap Penurunan Skala Nyeri Post Operasi Mastektomi Ca Mammae
Authors: Pasaribu Maya Ade Kusniarti , Sumarni Tri 
Published: July 2023

Latar Belakang : Nyeri pada pasien kanker pasca operasi mastektomi dapat disebabkan oleh efek negatif dari luka operasi, serta dapat memberikan dampak fisik dan psikologis pada seseorang, dimana seseorang sering mengalami rasa cemas dan nyeri saat menjalani kemoterapi. Tujuan: Penelitian ini bertujuan untuk mendeskripsikan pengaruh terapi murotal terhadap penurunan nyeri pada pasien pasca operasi mastektomi. Metode :Penelitian ini merupakan penelitian studi kasus dengan menggunakan teknik simple random sampling. Penelitian ini dilakukan pada bulan Desember 2022 dengan instrumen panduan penilaian pengumpulan data. Peneliti menggunakan proses asuhan keperawatan mulai dari tahap pengkajian hingga evaluasi. Hasil :Keluhan yang paling dirasakan dan mengganggu pasien adalah nyeri disekitar area operasi menjalar ke punggung skala 6, nyeri timbul dan pergi dan terasa seperti ditusuk. Nyeri akan terasa saat pasien bergerak. Pemberian intervensi terapi murotal menurunkan nyeri pada ca mammae pasca operasi mastektomi. Kesimpulan: terapi murotal merupakan intervensi yang efektif menurunkan nyeri pasca operasi mastektomi
FEATURES OF THE FORMATION OF LEGAL LITERACY OF STUDENTS OF NON-LEGAL AREAS OF PREPARATION IN THE PROCESS OF MASTERING THE DISCIPLINE «FUNDAMENTALS OF THE LEGAL STATUS OF A PERSON AND A CITIZEN OF THE RUSSIAN FEDERATION»
Authors: Фролова Елена Вячеславовна 
Published: July 2023

В научной статье рассматривается проблема формирования правовой грамотности студентов неюридических направлений подготовки в процессе правового образования в вузе. Сделан вывод о том, что правовая грамотность - это качество личности, выражающееся в совокупности правовых знаний и способности руководствоваться ими в различных сферах жизнедеятельности. Предложены некоторые пути, способствующие повышению эффективности формирования правовой грамотности студентов неюридических направлений подготовки за счет внедрения в учебные планы элективного курса «Основы правового статуса человека и гражданина» (на примере ФГБОУ ВО «Югорский государственный университет»).
Legal education at the university. It is concluded that legal literacy is a quality of personality expressed in the totality of legal knowledge and the ability to be guided by them in various spheres of life. Some ways are proposed that contribute to improving the effectiveness of the formation of legal literacy of students of non-legal areas of training through the introduction of the elective course «Fundamentals of the legal status of a person and a citizen» into the curricula (using the example of the Ugra State University).
FORMATION OF ANTI-CRISIS COMMUNICATIVE COMPETENCE OF BACHELOR ECONOMISTS: THE PRINCIPLE OF INTERDISCIPLINARITY
Authors: Андрух Алина Олеговна 
Published: July 2023

В статье рассматриваются эффективные условия применения принципа междисциплинарности при формировании антикризисной коммуникативной компетенции бакалавров-экономистов.
The article discusses the effective conditions for the application of the principle of interdisciplinarity in the formation of anti-crisis communicative competence of bachelor economists.
EFFICIENCY OF ORGANIC FERTILIZERS IN GROWING WINTER WHEAT IN STAVROPOL KRAI
Authors: Голосной Евгений Валерьевич , Марцинкевич Вячеслав Михайлович 
Published: July 2023

Опыт проведён в 2019-2022 гг. в Ставропольском крае на черноземе южном. Объектом исследований являлся сорт озимой пшеницы Еланчик. Предшественник - кукуруза на зерно.
The experiment was carried out in 2019-2022. in the Stavropol Territory on the southern chernozem. The object of research was the winter wheat variety Elanchik. Predecessor - corn for grain.
Competencias tecnológicas en los docentes
Authors: Paniagua Centurión Elena Concepción 
Published: July 2023

El objeto del presente estudio se orienta en dilucidar en torno a las competencias tecnológicas que debe poseer e implementar el docente durante su praxis y además se subraya la necesaria articulación con estrategias didácticas acordes para usar con las TIC y poder así concitar en el mayor aprovechamiento a las TIC. La metodología usada fue bajo el enfoque cualitativo, y se basó en la revisión bibliográfica, con la técnica de análisis documental. Los epílogos dan cuenta que: La formación de los docentes y su capacitación profesional continua, resulta fundamental para maximizar el aprovechamiento de los beneficios de las TIC; y de esa manera se podrá propiciar espacios de aprendizaje para que los educandos desarrollen las capacidades necesarias, incluyendo competencias digitales con aplicabilidad para la vida. A la luz de las nuevas formas de enseñanza, el docente puede disponer de diversos recursos y estrategias didácticas a usar a través de la tecnología. Se hace necesario reducir las brechas digitales para que los educandos logren el acceso a la educación con equidad, calidad e inclusión; y además resulta ineludible disminuir la brecha digital en los docentes para que se logre un mejor abordaje en la actividad pedagógica. La formación de los docentes en el uso de las TIC contribuye en la calidad educativa. Como desafío se destaca que los Estados y las instituciones educativas están llamados a que bajo sus políticas, proporcionen alternativas para impulsar y complementar la formación de los docentes en el uso de las tecnologías digitales en aras de lograr el mayor aprovechamiento y apropiación de las TIC para una educación de calidad y con pertinencia.