bluuebunny/crossref_metadata_2025_split huggingface dataset:
Graph Neural Network Enhancing Recommendation System based on Social Relationship and Attention Mechanism
Authors: Hawthorne  , Mercer Finley , Tzeng Dely , Hartman Jaxon 
Published: July 2023

Abstract
Traditional recommendation methods generally only take into account the information of entity objects, such as less consideration of social relationships, and generates the problem of insufficient capacity. Because the actual user-object interaction is non-Euclidean data, traditional recommendation algorithms are difficult to deal with this structural type of data, and it is difficult to achieve excellent recommendation results, so the traditional recommendation methods generally take into account the information of the user and the object itself, which makes the topological structure of the composition between the user-object information is lost, and the recommendation effect is limited. In this paper, on the basis of the variogram self-encoder that integrates the attention mechanism, we construct the user-item graph neural network and the user social graph neural network respectively, and improve the recommendation effect through the auxiliary social relationship network when making product recommendation, and propose a variogram self-encoder recommendation model that integrates the social relationship and the attention mechanism, which can fill in information of the target node with the auxiliary information of the user-item graph and the user-item graph neural network when the data is sparse. The model can fill in the information of the target node with assistance when the data is sparse, avoiding the problem that the data size has an excessive impact on the prediction effect, and improving the recommendation effect by introducing social relations and using different mapping relations between user-user and user-item at the same time.
PENGARUH PELATIHAN AKUNTANSI, DAN LAMA USAHA TERHADAP PERENCANAAN DAN PENGGUNA INFORMASI AKUNTANSI PADA UMKM KECAMATAN LOWOKWARU KOTA MALANG
Authors: Krisnawati Ayu , Widiastuti Linda Wahyu , Dura Justita , Renaldi Mochamad 
Published: July 2023

Untuk mengetahui pengaruh perencanaan dan penggunaan informasi akuntansi pada UMKM di kecamatan Lowokwaru Kota Malang. Teknik pengumpulan sampel dengan penyebaran kuesioner, dengan jumlah sampel sebanyak 97 responden. Metode penelitian yang digunakan menggunakan kuantitatif. Hasil penelitian menunjukkan bahwa pelatihan akuntansi dan lama usaha mempunyai pengaruh terhadap penggunaan informasi akuntansi di Kota Malang. Penelitian selanjutnya diharapkan dapat memperoleh data yang lebih yang luas dan komprehensif.
TANTANGAN DAN INOVASI PEMBELAJARAN PAI PADA MASA PANDEMI COVID-19
Authors: Murniasih Eri , Muhajir Muhajir 
Published: July 2023

Abstract: The Covid-19 pandemic has changed the order of learning, especially Islamic Religious Education (PAI), and presents its challenges for educators and students to quickly adapt the learning process from conventional to online internet-based learning or e-learning using various applications. This paper aims to examine what challenges and innovations in PAI learning are faced during the Covid-19 pandemic at the SMK Informatika in Serang City. The type of research used by the researcher is the descriptive qualitative research method. Data collection techniques using the research library and filling out questionnaires. The main data sources in this study were PAI subject educators and class XII students of SMK Informatika Serang and some literature. The results and conclusions in this study are: (a) SMK Informatika answers the challenges of online learning by creating an E-Learning application for SMK Informatika. (b) Educators and students at SMK Informatika agree that the role of teachers cannot be replaced by technological sophistication, especially PAI teachers who are tasked with shaping the character of students. (c) PAI educators in SMK Informatika innovate to conduct online and offline meetings regularly to inculcate character as the main goal of PAI (Blended Learning). (d) Family, Community, and Educators are the three main pillars of education, synergizing, supporting each other and their roles cannot be separated so that the main goal of PAI learning, namely character building, can be achieved even though learning is carried out online.Keyword: Challenges, Covid-19 Pandemic, Innovation, PAI Learning
PEDAGOGICAL SUPPORT OF THE PROFESSIONAL SELFDETERMINATION OF THE STUDENTS
Authors: Обухова Л.А. , Попова О.А. 
Published: July 2023

В настоящей статье приводится анализ деятельности региональных инновационных площадок, осуществляющих исследование по проблеме. Раскрыты формы, методы и средства, используемые на разных уровнях педагогической поддержки обучающихся в их профессиональном самоопределении.
The article provides an analysis of the work of the regional innovation platforms carrying out research on the «Development and implementation of an early self-determination model for students» issue. The forms, methods and means used at different levels of pedagogical support for students in their professional self-determination are disclosed.
Modelo de estrategias metacognitivas para promover el pensamiento crítico de los directivos de educación primaria del distrito de Chiclayo
Authors: Ynfante Saavedra María Cecilia , Moreno Muro Juan Pablo , Montenegro Camacho Luis Arturo 
Published: July 2023

El objetivo fue diseñar un modelo de estrategias metacognitivas para promover el pensamiento crítico en directivos de educación primaria del distrito de Chiclayo; se inició detectando el nivel de desarrollo del pensamiento crítico en directivos de educación primaria. La investigación fue de tipo básico con enfoque cuantitativo, el diseño fue no experimental de alcance descriptivo propositivo. La muestra de estudio estuvo constituida por 41 directivos del nivel de educación primaria del distrito de Chiclayo, a los cuales se aplicó la escala de Likert para la recolección de datos; se definió la confiabilidad mediante el cálculo de Alfa de Cronbach cuyo resultado arrojó un coeficiente de confiabilidad de 0,736; se constató como resultado que los directivos se encuentran en nivel bajo y medio sobre todo en la dimensión juicio a partir de situaciones concretas y relevantes para la variable del nivel de pensamiento crítico de los directivos; ello condujo a elaborar un diseño de estrategias metacognitivas que favoreciera prioritariamente el mejoramiento de la mencionada dimensión y permitiera concretar el objetivo de la investigación, el que fue validado a través del juicio de expertos, concluyéndose que es un modelo aplicable que contribuye a promover el desarrollo del pensamiento crítico en los directivos.
Pre-Course Inquiries
Authors: Fitriani Ika , Ridla Akhmad Zainur , Hudori Rizki Febri Andika 
Published: July 2023

Need analysis is a pivotal process prior to starting any courses in order to get initial classroom mapping about students’ needs and expectations. This current study aims to describe the result of need analysis conducted prior to the course of Bahasa Inggris for nursing students. The method employed is descriptive quantitative using data that were collected through questionnaires distributed to the students who are taking Bahasa Inggris course in the odd semester 2022/2023. The results show several points, such as the students belonged to the beginner to intermediate level of English users who merely used English in the classroom contexts. The most challenging language skill is speaking, yet they have had learning awareness to acquire all the language skills in the targeted language. The students also propose some criteria of good teaching materials, learning activities, as well as assessment forms. Finally, the result of this current study can be one of the considerations or the basis for future learning designers, course facilitators, and institutions to design the course which meets the students’ needs.

Keywords: English, need analysis, nursing students
Impact of Varieties and Foliar Spray of Micronutrient on Growth Parameters of Cluster Bean under Teak Based Agroforestry System
Authors: Bose Govind , Prajapati V. M. , Tandel M. B. , Patel N. K. , Patel D. P. , Garde Y. N. , Pathak J. G. , Chaudhari Virag , Behera Subhaprada 
Published: July 2023

Management of agroforestry system in different region has been widely focused on reducing soil erosion and water losses, environmental balance restoration, improve land use and uplifting economic benefits. This study was conducted to evaluating the impact of varieties and foliar application of micronutrient on growth parameters of cluster bean under teak based agroforestry system as well as open condition. The experiment was laid out in Randomized Block Design with Factorial concept consisting of 3 factors viz., varieties, foliar spray of micronutrient iron and foliar spray of micronutrient zinc at 2 levels each in 4 replications. Among two tested varieties, variety Pusa Navbahar performed well in terms of growth as compare to local variety in both growing conditions. Furthermore, foliar spray of 0.5% FeSO4 and foliar spray of 0.5% ZnSO4 also recorded maximum growth parameters as compare to their control condition under both growing conditions. All interaction effect were found non-significant for most of growth parameters except plant height under both growing conditions (teak-based agroforestry system and open condition). Further, t-test analysis shows that growth parameters were higher for open condition.
Recombinant protein purification and immobilization strategies based on peptides with dual affinity to iron oxide and silica
Authors: Aguiar Tatiana Q. , Domingues Lucília 
Published: July 2023

AbstractIron oxide and silica‐based materials have emerged as attractive protein purification and immobilization matrices. His6 has been reported as an effective affinity tag for both iron oxide and silica. Here, the silica‐binding tags CotB1p and Car9 were shown to work as effectively as iron oxide‐binding tags. Using EGFP as a model protein, commercially available bare iron oxide (BIONs) or silicon dioxide (BSiNs) nanoparticles as low‐cost purification/immobilization matrices, and non‐hazardous and mild binding and elution conditions, adsorption and desorption studies were performed with lysates from Escherichia coli‐producing cells to compare the performance of these dual‐affinity tags. Under the conditions tested, the His6 tag stood out as the best‐performing tag, followed by CotB1p. Our findings concluded the promising combination of these tags, BIONs and BSiNs for one‐step purification of recombinant proteins, and two‐step purification and immobilization of recombinant proteins without intermediate buffer exchange. This proof of concept work set the ground for future evaluation of these purification and immobilization strategies using other proteins with different properties, which will be of interest to expand their utility and applicability.
Glutaredoxin‐1 promotes lymphangioleiomyomatosis progression through inhibiting Bim‐mediated apoptosis via COX2/PGE2/ERK pathway
Authors: Feng Ya , Li Tianjiao , Li Yin , Lin Zhoujun , Han Xiao , Pei Xiaolin , Zhang Yupeng , Li Fei , Yang Juan , Shao Di , Li Chenggang 
Published: July 2023

AbstractBackgroundLymphangioleiomyomatosis (LAM) is a female‐predominant interstitial lung disease, characterized by progressive cyst formation and respiratory failure. Clinical treatment with the mTORC1 inhibitor rapamycin could relieve partially the respiratory symptoms, but not curative. It is urgent to illustrate the fundamental mechanisms of TSC2 deficiency to the development of LAM, especially mTORC1‐independent mechanisms. Glutaredoxin‐1 (Glrx), an essential glutathione (GSH)‐dependent thiol‐oxidoreductase, maintains redox homeostasis and participates in various processes via controlling protein GSH adducts. Redox signalling through protein GSH adducts in LAM remains largely elusive. Here, we demonstrate the underlying mechanism of Glrx in the pathogenesis of LAM.Methods1. Abnormal Glrx expression in various kinds of human malignancies was identified by the GEPIA tumour database, and the expression of Glrx in LAM‐derived cells was detected by real‐time quantitative reverse transcription (RT‐qPCR) and immunoblot. 2. Stable Glrx knockdown cell line was established to evaluate cellular impact. 3. Cell viability was determined by CCK8 assay. 4. Apoptotic cell number and intracellular reactive oxygen species (ROS) level were quantified by flow cytometry. 5. Cox2 expression and PGE2 production were detected to clarify the mechanism of Bim expression modulated by Glrx. 6. S‐glutathionylated p65 was enriched and detected by immunoprecipitation and the direct regulation of Glrx on p65 was determined. 7. The xenograft animal model was established and photon flux was analyzed using IVIS Spectrum.ResultsIn LAM, TSC2 negatively regulated abnormal Glrx expression and activation in a mTORC1‐independent manner. Knockdown of Glrx increased the expression of Bim and the accumulation of ROS, together with elevated S‐glutathionylated proteins, contributing to the induction of apoptotic cell death and inhibited cell proliferation. Knockdown of Glrx in TSC2‐deficient LAM cells increased GSH adducts on nuclear factor‐kappa B p65, which contributed to a decrease in the expression of Cox2 and the biosynthesis of PGE2. Inhibition of PGE2 metabolism attenuated phosphorylation of ERK, which led to the accumulation of Bim, due to the imbalance of its phosphorylation and proteasome degradation. In xenograft tumour models, knockdown of Glrx in TSC2‐deficient LAM cells inhibited tumour growth and increased tumour cell apoptosis.ConclusionsCollectively, we provide a novel redox‐dependent mechanism in the pathogenesis of LAM and propose that Glrx may be a beneficial strategy for the treatment of LAM or other TSC‐related diseases.
Interactions between temperature and predation impact insect emergence in alpine lakes
Authors: Owens Caroline H. , Lee Michelle J. , Grim Melissa , Schroeder John , Young Hillary S. 
Published: July 2023

AbstractWhile insect populations are simultaneously threatened by many local‐ and global‐scale stressors, the interacting effects of these factors remain poorly understood. These interactions between stressors, whether additive or antagonistic, may have profound effects on our assumptions about and predictions for any given system. Here we address this gap by exploring the interactive effects of introduced predators and elevated temperatures on emerging aquatic insects across alpine lakes. Using a crossed factorial field survey, we examine whether warmer temperatures either directly affect the magnitude or diversity of insect emergence, or mediate the impacts of predation via interactions with predator presence. Based on data from more than 11,000 insects collected across a two‐year period, we find a 71% reduction in insect emergence associated with an additional 3.6°C of water temperature in oligotrophic alpine lakes. While our work confirms prior findings that predator presence drives strong reductions in insect emergence, we find that the effects of predation are significantly weaker in warmer lakes (2% reduction in warmest lakes studied vs. 75% reduction in coldest). Combining our results with regional studies of predator communities to identify mechanisms suggests that the interaction effects between temperature and predator presence are likely due to changes in predator behavior across temperatures. Critically, to fully understand the multiple stressors that impact insect populations and predict their future effects, we must consider the interactions between stressors across spatial scales.
Intraspecific variation in habitat relationships for pygmy rabbits: Implications for conservation of habitat specialists
Authors: Rush Lindsey M. , Svancara Leona K. , Smith Ian T. , Knetter Sonya J. , Karl Jason W. , Rachlow Janet L. 
Published: July 2023

AbstractEnvironmental relationships can differ across the geographic range of species, especially for widespread generalists. Because habitat specialists are more vulnerable to environmental changes, incorrect assumptions about consistent habitat associations could hinder strategic conservation efforts. We used species distribution models (SDMs) to evaluate intraspecific variation in habitat associations for a habitat specialist of conservation concern, the pygmy rabbit (Brachylagus idahoensis), which is endemic to the sagebrush biome of the western United States. Our goal was to model habitat associations for pygmy rabbits across a portion of their range to evaluate regional variation and contrast predictions with results from a model developed at the rangewide extent. We created inductive SDMs using maximum entropy methods within five ecological regions that encompassed about 20% of the species rangewide distribution and spanned diverse environmental gradients. We included a suite of environmental predictor variables representing topography, vegetation, climate, and soil characteristics. Results of the regional models identified substantial variation in habitat associations across the five regions, with each retaining a unique set of environmental predictors. Bioclimatic variables were the most influential environmental parameters in all five regions, but the specific variables differed. The models developed at regional extents predicted smaller areas of habitat (an average of 15% less for suitable habitat and 80% less for primary habitat) than predictions generated from a model developed at the rangewide extent. Because bioclimatic variables were effective in discriminating areas used by pygmy rabbits, they also provided an opportunity to assess potential changes in habitat distribution by incorporating future climate projections. Distributions modeled under two mid‐century emission scenarios projected substantial reductions in suitable habitat for pygmy rabbits across most regions and pronounced variation among regions in the magnitude and direction of the climate effects. Collectively, results of this work underscore the need to incorporate regional variation in habitat associations into planning for current and future conservation and management strategies.
Modeled health economic and equity impact on dental caries and health outcomes from a 20% sugar sweetened beverages tax in Australia
Authors: Nguyen Tan Minh , Tonmukayakul Utsana , Khanh‐Dao Le Long , Singh Ankur , Lal Anita , Ananthapavan Jaithri , Calache Hanny , Mihalopoulos Cathrine 
Published: July 2023

AbstractDental caries is the most prevalent oral disease across the life course. This study modeled the population health and economic impact of a 20% sugar sweetened beverages tax (SSB) for preventing dental caries compared to no intervention (societal and healthcare perspective). A cost‐effectiveness analysis according to quintiles of area‐level socioeconomic disadvantage was performed for the 2020 Australian population (0–100 years old) using a closed cohort Markov model. A qualitative assessment of implementation considerations (e.g., acceptability, equity, sustainability) was undertaken. Health outcomes were modeled as decayed teeth prevented and disability‐adjusted life years (DALYs) averted. The 10‐year and lifetime scenarios were modeled with probabilistic sensitivity analysis (Monte Carlo simulation, 2000 cycles). The 10‐year scenario from a societal perspective yielded cost‐savings of AUD$63.5M, healthcare cost‐savings of AUD$42.2M, 510,977 decayed teeth averted and 98.1 DALYs averted. The lifetime scenario resulted in societal cost savings of AUD$176.6M, healthcare cost‐savings of AUD$122.5M, 1,309,211 decayed teeth averted and 254.9 DALYs averted. Modeling indicated 71.5% and 74.5% cost‐effectiveness for the 10‐year and lifetime scenarios, respectively. A three‐fold health benefit for the least advantaged was found compared to the most advantaged. A 20% SSB tax in Australia is cost‐effective and promotes health equity.
Comparative health policy goes qualitative: Broadening the focus of research after COVID‐19
Authors: Burau Viola , Kuhlmann Ellen , Lotta Gabriela 
Published: July 2023

AbstractThe COVID‐19 pandemic has pushed health policy frontstage and exposed the stark differences in government capacities to respond to the crisis. This has created new demands for comparative heath policy to support knowledge creation on a large scale. However, comparative health policy has not necessarily been well prepared; studies have focused on health systems and used typologies together with descriptive, quantitative methods. This makes it difficult to capture the multi‐level nature of health policy, the diverse actors involved and the many societal facets of governance performance. We argue for broadening the perspective to include health policy as a bottom‐up process with diverse interests. This calls for expanding the methodology of comparative health policy by also using approaches that make greater use of explorative, qualitative research. We introduce possible developmental pathways to illustrate what this may look like. The Pan‐European Commission shows how to broaden the definition of comparative health policy, notably as transnational and planetary. The gender analysis matrix illustrates how comparative health policy can strengthen its assessment of performance by focussing on gender equity. The street‐level bureaucrat framework highlights how analysing frontline work can help conduct small‐scale bottom‐up comparisons of health policy. Together, these developmental pathways demonstrate the potential to broaden comparative health policy towards greater responsiveness to the societal performance of governments, such as social inequalities created by the COVID‐19 pandemic. This also opens opportunities for strengthening the global outlook of comparative health policy.
Perceived importance of weight loss and exercise among endometrial cancer survivors with overweight or obesity: Implications for lifestyle modification interventions
Authors: Tagai Erin K. , Mantia‐Smaldone Gina M. , Belfiglio Andrew , Chu Christina S. , Lapitan Emmanuel , Santos Heather , Hernandez Enrique , Sarwer David B. , Miller Suzanne M. 
Published: July 2023

AbstractObjectiveType 1 endometrial cancer (EC) survivors who are overweight or obese are at increased risk of comorbidities and reduced quality of life. Lifestyle modification interventions (e.g., healthy eating, exercise) may help these women reduce excess weight and improve their quality of life. However, existing interventions have shown limited success. Guided by Self‐Determination Theory, the proposed study sought to identify factors associated with perceived importance of weight loss and exercise as well as interest in lifestyle modification interventions (components of extrinsic and intrinsic motivation) among EC survivors with overweight or obesity to inform future intervention development.MethodsOne hundred type 1 EC survivors [body mass index (BMI) ≥ 25 kg/m2] completed a cross‐sectional survey assessing sociodemographics, medical factors, exercise, risk perceptions and provider communication, quality of life, barriers to dieting and exercise, perceived importance of healthy lifestyles, and desired intervention content.ResultsEC survivors who were aware obesity is a risk factor for EC were significantly more likely to perceive weight loss as important and were interested in weight loss programs and receiving information about exercise (ps < 0.05). Additionally, EC survivors who reported their provider discussed the importance of a healthy weight after their diagnosis were significantly more likely to perceive exercise as important and were interested in receiving dieting information.ConclusionsEC survivors expressed interest in lifestyle modification interventions. Increasing awareness about the risk of obesity and provider discussions about healthy weight during routine appointments may motivate EC survivors to engage in lifestyle modification interventions.