bluuebunny/crossref_metadata_2025_split huggingface dataset:
Numerical Analysis on Detonation Wave and Combustion Efficiency of Pulse Detonation Combustor With U-Shape Combustor
Authors: Debnath Pinku , Pandey K. M. 
Published: June 2023

Abstract
The research work is carried out for deflagration and detonation combustion processes at different equivalence ratios of hydrogen–air mixtures in a pulse detonation combustor (PDC). Furthermore, the U-shape channel curvature radius and thickness effect on detonation wave propagation are also investigated. This numerical simulation has been done using a SIMPLE algorithm with the finite volume discretization method and laminar finite rate chemistry for volumetric reaction in the Ansys Fluent platform. The numerical result shows that the U-bend radius of R = 3.5 cm can enhance the faster deflagration-to-detonation transition. So far, the fully developed detonation wave was found near the curvature area of the detonation tube having a width of W = 8 cm. This enhanced detonation wave velocity reaches 2775 m/s, which is higher than the C-J detonation velocity. Furthermore, the entropy generation has been analyzed in two modes of the combustion process. The entropy generation number of 0.76 and 0.7 is obtained from the deflagration and detonation combustion processes. However, the entropy production rate is less in the detonation combustion process, but thermal entropy generation is more in the deflagration combustion process with a magnitude of 3.5 kJ/kg K for an equivalence ratio of φ = 1.5. A combustion efficiency of 78% is found in the detonation combustion process, which is comparatively higher than the deflagration process.
Supplemental Material: Magma migration and surface uplift in Pamir–western Tibet driven by deep lithospheric dynamics
Authors: Tang Gong-Jian , al. et 
Published: June 2023

<p>The analytical methods and zircon U-Pb ages, Hf-O isotopes for the (ultra)potassic rocks in Pamir–western Kunlun, and summary of published data of the ages of the (ultra)potassic rocks from the Pamir-western Tibet, and AFT and ZHe ages. Tables S1–S4 and Figures S1 and S2. </p>
Recurrence of syncope after valve replacement in severe aortic stenosis
Authors: San Román J Alberto , Ybarra-Falcón Cristina , García-Gómez Mario , Ramos Noemí , Amat-Santos Ignacio J , Sevilla Teresa , Revilla Ana , Carrasco-Moraleja Manuel , Lopez Javier , Cabezón Gonzalo , Rollán María Jesús , Vilacosta Isidre 
Published: June 2023

ObjectiveThe recurrence of syncope after valve intervention in severe aortic stenosis (SAS) and its impact on outcome are unknown. We hypothesised that syncope on exertion will disappear after intervention, whereas syncope at rest might recur. Our aim has been to describe the recurrence of syncope in patients with SAS undergoing valve replacement and its impact on mortality.MethodsDouble-centre observational registry of 320 consecutive patients with symptomatic SAS without other valve disease and/or coronary artery disease who underwent valve intervention and were discharged alive. All-cause mortality and cardiovascular mortality were considered events.Results53 patients (median age 81 years, 28 men) had syncope (29 on exertion, 21 at rest, 3 unknown). Clinical and echocardiographic variables were similar in patients with and without syncope (median vmax4.44 m/s, mean gradient 47 mm Hg, valve area 0.7 cm2, left ventricular ejection fraction 62%). After a median follow-up of 69 months (IQR: 55–88), syncope on exertion did not recur in any patient. In contrast, 8 of the 21 patients with syncope at rest had postintervention syncope at rest (38%; p<0.001): 3 needed a pacemaker, 3 were neuromediated or hypotensive and 2 arrhythmic. Only recurrence of syncope was associated with cardiovascular mortality (HR 5.74; 95% CI 2.17 to 15.17; p<0.001).ConclusionsSyncope on exertion in patients with SAS did not recur after aortic valve intervention. Syncope at rest recurs in a high proportion of patients and identifies a population with increased mortality. According to our results, syncope at rest should be thoroughly evaluated before proceeding to aortic valve intervention.
Multi-institutional Prognostic Modeling in Head and Neck Cancer: Evaluating Impact and Generalizability of Deep Learning and Radiomics
Authors: Kazmierski Michal , Welch Mattea , Kim Sejin , McIntosh Chris , Rey-McIntyre Katrina , Huang Shao Hui , Patel Tirth , Tadic Tony , Milosevic Michael , Liu Fei-Fei , Ryczkowski Adam , Kazmierska Joanna , Ye Zezhong , Plana Deborah , Aerts Hugo J.W.L. , Kann Benjamin H. , Bratman Scott V. , Hope Andrew J. , Haibe-Kains Benjamin 
Published: June 2023

Artificial intelligence (AI) and machine learning (ML) are becoming critical in developing and deploying personalized medicine and targeted clinical trials. Recent advances in ML have enabled the integration of wider ranges of data including both medical records and imaging (radiomics). However, the development of prognostic models is complex as no modeling strategy is universally superior to others and validation of developed models requires large and diverse datasets to demonstrate that prognostic models developed (regardless of method) from one dataset are applicable to other datasets both internally and externally. Using a retrospective dataset of 2,552 patients from a single institution and a strict evaluation framework that included external validation on three external patient cohorts (873 patients), we crowdsourced the development of ML models to predict overall survival in head and neck cancer (HNC) using electronic medical records (EMR) and pretreatment radiological images. To assess the relative contributions of radiomics in predicting HNC prognosis, we compared 12 different models using imaging and/or EMR data. The model with the highest accuracy used multitask learning on clinical data and tumor volume, achieving high prognostic accuracy for 2-year and lifetime survival prediction, outperforming models relying on clinical data only, engineered radiomics, or complex deep neural network architecture. However, when we attempted to extend the best performing models from this large training dataset to other institutions, we observed significant reductions in the performance of the model in those datasets, highlighting the importance of detailed population-based reporting for AI/ML model utility and stronger validation frameworks. We have developed highly prognostic models for overall survival in HNC using EMRs and pretreatment radiological images based on a large, retrospective dataset of 2,552 patients from our institution.Diverse ML approaches were used by independent investigators. The model with the highest accuracy used multitask learning on clinical data and tumor volume.External validation of the top three performing models on three datasets (873 patients) with significant differences in the distributions of clinical and demographic variables demonstrated significant decreases in model performance.

Significance:
ML combined with simple prognostic factors outperformed multiple advanced CT radiomics and deep learning methods. ML models provided diverse solutions for prognosis of patients with HNC but their prognostic value is affected by differences in patient populations and require extensive validation.
Demographics and Client Satisfaction on the Establishment of Driver’s License Renewal Office
Authors: Donato Noreen Grace D. , Ramos Jelyn A. 
Published: June 2023

This research study is an effort to determine the relationship between demographics and client satisfaction on the establishment of Driver’s License Renewal Offices. A Purposive Sampling survey method was utilized in collecting data using a revised Client Survey Questionnaire based on the Land Transportation Office Client Satisfaction Measurement Survey Form. The demographics of respondents were taken into account in terms of gender and age bracket. This research study utilized the Descriptive Statistics and Hypothesis Testing using the P-Value approach in deriving the conclusion that there is no significant difference on Demographics and Client Satisfaction and the Land Transportation office should support the program of establishing additional Driver’s License Renewal Offices nationwide. Furthermore, this study has come to the conclusion that the majority of the clients at Driver’s License Renewal Offices have a high level of client satisfaction and demographics do not have a high contributing factor on assessing the level of client satisfaction. Regardless of sex and age, an efficient service delivery can be recognized and acknowledged.
Preparedness among Reserve Officers' Training Corps Graduates on the Rigors of ROTC and Defense Security: Basis for Policy Enhancement
Authors: Gantalao Jilmar S. 
Published: June 2023

The Philippines Reserve Officers' Training Corps aims to provide military education and training for students to mobilize them for national defense preparedness. This study aimed to assess the rigor of the Philippine Reserve Officers' Training Corps, and defense and security preparedness among ROTC graduates in selected universities in the Philippines, and determined the significant difference in the perceived level of preparedness on the rigor of the Philippine RTOC among Military Science courses graduates in selected universities such as: physical organization of cadets, combat training of individual soldiers, regional annual administrative and tactical inspection, drill and ceremonies, infantry, rescue, field artillery, and; civil operation activities as assessed by the three groups of respondents. Moreover, the study also determined the significant difference in the perceived level of preparedness on defense and security such as: internal security operations, territorial defense, disaster response, international defense, security engagements, international humanitarian assistance, peacekeeping operations, and support to national development as assessed by the two (2) groups of respondents. This study utilized a descriptive correlational research design. The study covered 200 respondents; composed of 100 Military Science 42 Graduates, and 100 Military Science 43 graduates conducted during the School Year 2022 – 2023. Generally, the respondents were Highly Prepared for the rigor of the Reserved Officers Training Corps. On the other hand, the respondents were Highly Prepared on defense and security as embedded in the Reserved Officers Training Corps. Further studies may be conducted using empirical evidence to further the implementation of ROTC mandates, supplementation to an early career in AFP, and the impact of ROTC on both high school and college graduates in the Philippines.
Learning Purposive Communication: A Personal Narrative Experience of Non-Teacher Education Students
Authors: Salendab Fahad Abdul , Laguda Jorge Loja 
Published: June 2023

This research explored the learning experiences of non-teacher education students enrolled in Purposive Communication at Sultan Kudarat State University-Kalamansig Campus. The study employed a qualitative design and non-probability purposive sampling. This study included six(6) non-teacher education students participants, such as students taking BS in Information Technology, BS in Biology, and BS in Fisheries. For data collection and collection, a semi-structured interview guide question was used. Colizzi’s thematic analysis was employed to analyze the data. The learning experiences of non-teacher education students in purposive communication revealed that they enjoyed learning Purposive communication through hybrid learning. Various performance tasks were provided for the students to perform, and these tasks are based on real-life experience. In performing these tasks, English was evident as a medium of instruction. Non-teacher education students can integrate responsive examples in the community and the global arena.
Further, the most common challenges experienced by non-teacher education students were technical issues, distractions, time management, understanding course expectations, lack of in-person interaction, adapting to unfamiliar technology, and uncertainty about the future. It is recommended that the institution implement a monitoring strategy that would sustain the teaching methods employed by the teachers to make the teaching-learning process effective and productive in Purposive communication. The institution must provide sound-based classroom management during the new normal education and religiously implement hybrid learning to maintain the learning process. The institution should provide learning tools for poor but deserving non-teacher education students to assist them in learning Purposive communication even in times of educational crisis.
What Makes the Detection of Movement Different Within the Autistic Traits Spectrum? Evidence From the Audiovisual Depth Paradigm
Authors: Poulain Rachel , Batty Magali , Cappe Céline 
Published: June 2023

Abstract
Atypical sensory processing is now considered a diagnostic feature of autism. Although multisensory integration (MSI) may have cascading effects on the development of higher-level skills such as socio-communicative functioning, there is a clear lack of understanding of how autistic individuals integrate multiple sensory inputs. Multisensory dynamic information is a more ecological construct than static stimuli, reflecting naturalistic sensory experiences given that our environment involves moving stimulation of more than one sensory modality at a time. In particular, depth movement informs about crucial social (approaching to interact) and non-social (avoiding threats/collisions) information. As autistic characteristics are distributed on a spectrum over clinical and general populations, our work aimed to explore the multisensory integration of depth cues in the autistic personality spectrum, using a go/no-go detection task. The autistic profile of 38 participants from the general population was assessed using questionnaires extensively used in the literature. Participants performed a detection task of auditory and/or visual depth moving stimuli compared to static stimuli. We found that subjects with high-autistic traits overreacted to depth movement and exhibited faster reaction times to audiovisual cues, particularly when the audiovisual stimuli were looming and/or were presented at a fast speed. These results provide evidence of sensory particularities in people with high-autistic traits and suggest that low-level stages of multisensory integration could operate differently all along the autistic personality spectrum.
Dual Task Performance in Adolescents With Idiopathic Scoliosis
Authors: Yagci Gozde , Metin Gulnihal , Erel Suat , Erbahceci Fatih 
Published: June 2023

Daily life activities commonly include many combinations of dual tasks. Although dual task ability has been studied in healthy young adults, dual task performance in adolescents with idiopathic scoliosis (IS) has not been explored. Our objective in this study was to investigate dual task performance in adolescents with IS. We paired 33 adolescents diagnosed with IS and 33 healthy control participants (age range: 11–17 years) and administered to both groups the Stroop Color and Word test as a measure of cognitive ability, and both the Expanded Timed Up and Go (ETUG) test and the Tandem Gait test as measures of motor tasks. During the motor tasks, we had participants spell five-letter words in reverse and count down by seven from a randomly presented number between 50 and 100 to assess their dual task (cognitive-motor) performance. All cognitive, motor, and dual cognitive-motor test scores differed significantly between the IS and healthy control groups. The time taken to complete all these tasks was longer for participants with IS compared with controls ( p < .05). These results revealed diminished performances on dual cognitive-motor tasks among adolescents with IS when compared to peers without IS. Dual task performance is a new research paradigm in the scoliosis rehabilitation field, and it should be further investigated in future studies.
Veno-arterial extracorporeal membrane oxygenation versus standard medical management for massive pulmonary embolism
Authors: Kelty Catherine E , Berjaoui Wael , Shrestha Nabin K , Fitch Stephen , Jovinge Stefan M , Rendon Renzo Loyaga 
Published: June 2023

Purpose There is limited research on the use and outcomes of veno-arterial extracorporeal membrane oxygenation (VA-ECMO) treatment for massive pulmonary embolism (PE). This study compared VA-ECMO treatment for massive PE versus patients treated medically. Materials and methods Patients diagnosed with massive PE at one hospital system were reviewed. VA-ECMO and non-ECMO groups were compared by t test and Chi-square. Mortality risk factors were identified by logistic regression. Survival was assessed by Kaplan Meier and propensity matching of groups. Results Ninety-two patients were included (22 VA-ECMO and 70 non-ECMO). Age (OR 1.08, 95% CI 1.03–1.13), arterial SBP (OR 0.97, 95% CI 0.94–0.99), albumin (OR 0.3, 95% CI 0.1–0.8), and phosphorus (OR 2.0, 95% CI 1.4–3.17) were independently associated with 30-day mortality. Alkaline phosphate (OR 1.03, 95% CI 1.01–1.05) and SOFA score (OR 1.3, 95% CI 1.06–1.51) were associated with 1-year mortality. Propensity matching showed no difference in 30-day (59% VA-ECMO versus 72% non-ECMO, p = 0.363) or 1-year survival (50% VA-ECMO versus 64% non-ECMO, p = 0.355). Conclusions Patients treated with VA-ECMO for massive PE and medically treated patients have similar short- and long-term survival. Further research is needed to define clinical recommendations and benefits of intensive therapy such as VA-ECMO in this critically ill population.
Post-COVID-19 depression and anxiety in patients with systemic lupus erythematosus
Authors: Abd EL-Khalik Dina M. , Eltohamy Mohamed 
Published: June 2023

Objectives This study aimed to evaluate depression and anxiety in patients with systemic lupus erythematosus (SLE) in the post-coronavirus disease-2019 (COVID-19) period and their potential association with the disease activity and related organ damage. Patients and Methods This is a case–control study including 120 adult Egyptian patients with SLE: sixty patients with SLE who were proven previously to be positive for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) by polymerase chain reaction (PCR) and recovered during the 3 months prior to the study were included in the case group and an equal number of age- and sex-matched patients with SLE and no evidence of SARS-CoV-2 infection were included in the control group. Patients’ clinical history was collected, and they underwent clinical evaluation, including SLE disease activity, damage assessment, and psychological assessment. Results The mean depression and anxiety scores were significantly higher in cases than in the control group. Both scores showed a significant positive correlation with age, disease duration, the Systemic Lupus International Collaborating Clinics/American College of Rheumatology (SLICC/ACR) Damage Index for SLE (SDI), and SLE disease activity index (SLEDAI) and a significant negative correlation with education years. Hierarchical multivariate regression analyses revealed that COVID-19 infection was a predictor for severe depression and moderate-to-severe anxiety. Conclusions Patients with SLE, who are already vulnerable to physiological stressors, are especially predisposed to more risk of anxiety and depression when they are contracted with COVID-19 disease. Furthermore, anxiety and depression are associated with SLE activity and damage scores, and COVID-19 infection is a significant predictor for their severity. These results suggest that healthcare providers should give special attention to the mental health of SLE patients, especially during the COVID-19 pandemic.
Apalutamide-induced lichenoid reaction in a patient with non-metastatic castrate-resistant prostate cancer
Authors: Cremante Malvina , Puglisi Silvia , Gandini Annalice , Guadagno Antonio , Catalano Fabio , Damassi Alessandra , Murianni Veronica , Llaja Obispo Miguel Angel , Banna Giuseppe Luigi , Buti Sebastiano , Rebuzzi Sara Elena , Rescigno Pasquale , Fornarini Giuseppe 
Published: June 2023

Introduction Apalutamide is an oral selective androgen receptor inhibitor, approved by the FDA for the treatment of patients with non-metastatic, castration-resistant prostate cancer (M0 CRPC) at high risk of developing metastases and for patients with metastatic castration-sensitive prostate (mHSPC) in association with androgen deprivation therapy (ADT). In the registration studies, skin reactions were reported among the most common side effects and as an adverse event of special interest. Case Report Apalutamide-induced rash includes a wide spectrum of different types of skin reactions, but few cases reports and case series have described this adverse event. Here, we report an M0 CRPC patient who experienced a rare skin adverse event, a lichenoid reaction. Management & Outcome After 4 months of therapy with apalutamide, the patient reported dorsal pricking and dry skin. Lichenoid reaction was confirmed histologically and its correlation to the drug was demonstrated after pursuing a multidisciplinary approach. Discussion To our knowledge, this is one of the first cases of Apalutamide-related lichenoid reaction and this clinical case showed the relevance of a multidisciplinary management when assessing drug-related adverse events. A broader knowledge of the spectrum of drug-related reactions would allow for a better diagnosis and therapy management by both physicians and patients.
Correlation Study Between Spinal Cord Function, Spinal Cord Morphology and Cervical Spine Alignments in Patients With Hirayama Disease
Authors: Gao Yuan , Sun Chi , Zhou Shuyi , Zhang Fan , Jiang Jianyuan , Zhang Jun , Wang Hongli 
Published: June 2023

Objective This study aimed to explore the relationship between diffusion tensor imaging (DTI) parameters, cervical spine alignments, and spinal cord morphological parameters in patients with Hirayama disease (HD). Methods In this retrospective cohort study, 41 HD patients were recruited from the Huashan hospital from July 2017 to November 2021. Patients received X-rays, conventional magnetic resonance (MR), and DTI scans in flexion and neutral positions. The DTI parameters assessed were calculated using the region of interest (ROI) method. Paired t-tests were performed on the DTI parameters of neck flexion and neutral position. Cervical spine alignments, including flexion and neutral Cobb angles, were measured, and range of motion (ROM) was calculated. Spinal cord morphological parameters were measured, including spinal cord atrophy (SCA) and loss of attachment (LOA). Spearman’s correlation analysis between DTI parameters, cervical spine alignments, and spinal cord morphological parameters was performed. Results In comparing DTI parameters, segments of the C3/4, C4/5, C6/7, and lower cervical spine were significantly different, while segments of C5/6 were not significantly different. In Spearman’s correlation analysis, the flexion Cobb angle was significantly correlated with the fractional anisotropy (FA) value ( R2 = .111, P = .033) and apparent diffusion coefficient (ADC) value ( R2 = .119, P = .027). Flexion FA values were correlated with SCA in C4/5 ( R2 = .211, P = .003), C5/6 ( R2 = .454, P < .001), and C6/7 ( R2 = .383, P < .001) while flexion ADC values were correlated with SCA in the C4/5 ( R2 = .178, P = .006), C5/6 ( R2 = .388, P < .001) and C6/7 segments ( R2 = .187, P = .005). Conclusion The DTI parameters were correlated with the flexion Cobb angle and the SCA. These data support the dynamic cervical flexion compression hypothesis and indicate that the degree of SCA may be used to assess the condition of HD patients quantitatively.