bluuebunny/crossref_metadata_2025_split huggingface dataset:
Преконцепционните грижи като пресечна точка на промоцията на здравето и редките болести
Authors: Христова-Атанасова Елеонора , Стефанов Румен 
Published: March 2023

Репродуктивното здраве и нагласи на хората са важна част от цялостната концепция за здраве и имат своите отражения върху демографското развитие на дадена страна и нивото на нейното обществено здраве. Демографската криза и нейните предизвикателства налагат необходимост от проучване на информираността и нагласите на обществото и формулиране на решения за трайно повишаване на възпроизводството на населението. Съпрузите имат задължение да осигуряват благополучието на семейството и да се грижат за отглеждането, възпитанието и образованието на децата съобразно своите възможности, имущество и доходи.
За формирането на правилен мироглед по отношение на плодовитостта и възпроизводството на населението, необходимо е младите семейства да бъдат добре информирани за състоянието на раждаемостта и нейното ниво в България, така и за пътищата и методите за съзнателно планиране и формиране на съвременното семейство. Чрез създаване на здраво потомство, семейството поддържа биологичната непрекъснатост на рода, обществото и нацията. Налице са единични проучвания в България, свързани с ролята и значението на преконцепционните дейности, позволяващи всяка личност и двойка да постигнат желания от тях брой деца и времето на раждането им.
Наследствен ангиоедем
Authors: Ганева Маргарита 
Published: March 2023

Наследственият ангиоедем (НАЕ) е заболяване, характеризиращо се с рецидивиращи пристъпи на ангиоедем, засягащи най-често кожата или мукозата на горни дихателни пътища или гастроинтестиналния тракт. Унаследява се автозомно-доминантно и е резултат от мутация в гена SERPING1, кодиращ С1-инхибитора. Отокът, който се наблюдава при НАЕ, е резултат от ексцесивна продукция на брадикинин, потентен медиатор на вазодилатация. Два са основните типа НАЕ – тип I с дефицит на С1-инхибитор (съставляващ около 85% от случаите) и тип II с дисфункция на С1-инхибитор (наблюдаван в около 15% от случаите). Съществува и форма на НАЕ с нормални нива и функция на С1-инхибитор.
Диагностицирането на НАЕ изисква наличие на ниско ниво на С4 фракция на комплемента плюс намалена концентрация и/или функция на С1-инхибитора. Съществуват три групи лекарства за НАЕ – такива за терапия при нужда, такива за краткосрочна профилактика и такива за дългосрочна профилактика на пристъпите. Изключителният напредък в терапията на НАЕ предоставя все по-добро качество на живот на пациентите.
Рядък случай на пациент с токсична епидермална некролиза (синдром на Лайел)
Authors: Мазнев Михаил , Дерменджиев Светлан , Туфкова Стоилка , Божилов Владимир , Низамова Веселина , Мурджева-Манолова Мария 
Published: March 2023

Токсичната епидермална некролиза, въпреки че е рядко срещано заболяване, е животозастрашаващо състояние с висока смъртност (25–70%), характеризиращо се със свличане на епидермиса и засягане на лигавиците. Най-често токсичната епидермална некролиза може да възникне вследствие на употреба на различни групи медикаменти, но възможни причинители могат да бъдат също инфекция, тумори и ваксини. Синдромът на Стивън-Джонсън се счита, че е в същия спектър на епидермолизата, предизвикана от лекарства, като разликата е в степента на засягане на кожата.
Представяме случай на пациент с токсична епидермална некролиза с подлежащо туморно заболяване и употреба на антибиотик. Случаят служи, за да покаже комплексността на диагностично-терапевтичните мероприятия при това рядко заболяване.
Анализ на употребата на лекарства за лечение на спинална мускулна атрофия в България
Authors: Хайвазова Янна , Петкова Анна , Миткова Зорница , Камушева Мария 
Published: March 2023

Цел: Целта е да се анализира употребата на лекарства за спинална мускулна атрофия (СМА), реимбурсирани в България.
Материали и методи: Проведено е ретроспективно количествено проучване на лекарствената употреба (ЛУ) в България на лекарствени продукти за лечение на СМА, заплатени от Национална здравноосигурителна каса (НЗОК), за периода 2020 – 2021 г.
Резултати: Реимбурсираните лекарства за лечение на СМА към юли 2022 г. са nusinersen и risdiplam. Risdiplam е включен в Позитивния лекарствен списък в края на 2021 г., като към момента не са налични данни за употребата и затова не е обект на проучването. Разходите за лечение с nusinersen, заплащани от НЗОК, са 14 951 090.40 лв. през 2020 г. и 25 099 009.10 лв. през 2021 г., като тенденцията е за увеличаване в следващите 2 години. Лекарствената употреба, измерена чрез ДДД/1000души/ден, също нараства – 0.0043 ДДД/1000 души/ден през 2020 г. и 0.0077 ДДД/1000 души/ден през 2021 г.
Заключение: Проучването показва ръст в реимбурсираната сума на nusinersen през 2021 г. спрямо 2020 г., с пик в третия триместър на годината. Ръст се наблюдава и в относителния показател ДДД/1000 души/ден за 2021 г. Необходимо е последващо анализиране на ЛУ след започване на реалното заплащане на risdiplam от НЗОК от началото на 2022 г.
Modified Weighted Uniform Distribution And Its Bivariate Extension
Authors: Muhammed Hiba Zeyada , Abdelghany Hagar Mohamed 
Published: March 2023

In this paper a new version of weighted uniform distribution is constructed and studied. The statistical properties of the new distribution including the behavior of hazard and reversed hazard functions, moments, the central moments, moment generating function, mean, variance, coefficient of skewness, coefficient of kurtosis, median, mode, quantile , stochastic ordering and order statistics are also obtained, a simulation study and real data applications are performed. Moreover, a bivariate extension of the new distribution named the bivariate modified uniform (BMWU) distribution is introduced. The proposed bivariate distribution is of type Farlie–Gumbel–Morgenstern (FGM) copula. The BMWU distribution has modified weighted uniform marginal distributions. The joint cumulative distribution function, the joint survival function, the joint probability density function, the joint hazard rate function and the statistical properties of the BMWU distribution are also derived.
The Effects of Pancreatic Omentoplasty on Weight Loss, Improvement of Triglyceride and Interleukin-1 Levels in Obese Rats with Type II Diabetes Mellitus Performed Sleeve Gastrectomy
Authors: Prasetya Anggoro Teguh , K. Heri Nugroho  , Abdul Mughni  
Published: March 2023

Background: Obesity can trigger inflammation or inflammatory disease, which is one of the main features of adipose tissue dysfunction. Adipose secretes several different peptides called adipocytokines, which can induce several pro-inflammatory cytokines such as IL-6, TNF-α, and IL-1. Omentoplasty pancreas dan sleeve gastrectomy is a surgical technique that can treat overweight and metabolic syndrome in obesity and type II DM. This study aims to determine the effect of pancreatic omentoplasty on weight loss and improvement of triglyceride and interleukin-1 levels in rats obesity with type II diabetes mellitus performed sleeve gastrectomy.
Methods: This study is an experimental study in vivo. Eighteen rats participated in this study and were grouped into the control group (KI) and the KII and KIII treatment groups. Triglyceride levels were assessed using the spectrophotometric method, and IL-1 levels were assessed using the ELISA method. Data analysis was carried out using SPSS univariate and bivariate.
Results: The KII and KIII treatment groups experienced a decrease in body weight, triglyceride levels, and Interleukin-1 levels of rats after the treatment intervention, p<0.05. The KIII treatment group showed the most significant reduction in body weight, triglyceride levels, and Interleukin-1 levels compared to the KII treatment.
Conclusion: Pancreatic omentoplasty is effective in reducing body weight, reducing triglyceride levels, and reducing IL-1 levels in obese rats with type II diabetes mellitus undergoing sleeve gastrectomy surgery.
New Minerals from the Redmond Mine, North Carolina, USA: I. Redmondite, Hydroredmondite, and Sulfatoredmondite, Three Minerals Containing the Novel [Pb8O2Zn(OH)6]8+ Structural Unit
Authors: Kampf Anthony R. , Smith Jason B. , Hughes John M. , Ma Chi , Emproto Christopher 
Published: March 2023

AbstractThe new minerals redmondite (IMA2021–072), [Pb8O2Zn(OH)6](S2O3)4, hydroredmondite (IMA2021–073), [Pb8O2Zn(OH)6](S2O3)4·2H2O, and sulfatoredmondite (IMA2021–089), [Pb8O2Zn(OH)6](SO4)4·6H2O, were found in the Redmond mine, Haywood County, North Carolina, USA, where they occur together in a highly unusual secondary assemblage that comprises a variety of rare Pb-Zn-Cu sulfates, thiosulfates, and carbonates. The properties of redmondite are as follows: colorless to shades of brown, transparent equant rhombs to about 1 mm; white streak; adamantine luster; brittle; Mohs hardness 2; conchoidal fracture; no cleavage; 5.757 g/cm3 calculated density; biaxial with α = 1.96–1.97, β = 1.97–1.98, γ = 1.97–1.98; extreme dispersion. The properties of hydroredmondite are as follows: colorless, transparent prisms, blades, and tablets up to about 1 mm; white streak; adamantine luster; brittle; Mohs hardness 2; curved and stepped fracture; good cleavages on {101} and ; 5.124 g/cm3 calculated density; biaxial (+) with α = 1.830(5), β = 1.880(calc), γ = 1.950(calc), 2Vmeas = 83(1)°. The properties of sulfatoredmondite are as follows: colorless, transparent wedge-shaped crystals to about 2 mm; white streak; adamantine luster; brittle; Mohs hardness 2; curved, irregular fracture; no cleavage; 5.173 g/cm3 calculated density; biaxial (+), α = 1.780(5), β = 1.850(calc), γ = 1.860(calc), 2Vmeas = 40(3)°; moderate r &gt; v dispersion. Electron probe microanalyses provided the empirical formulae: Pb8.16Zn1.00S6+3.97S2−3.97O20H5.79, Pb8.00Zn1.00S6+4.00S2−4.00O22H9.98, and Pb8.00Zn0.99S6+4.00S2−0.89O29.11H17.98 for redmondite, hydroredmondite, and sulfatoredmondite, respectively. Redmondite is monoclinic, P21/c, a = 9.1672(4), b = 10.6576(4), c = 14.0620(10) Å, β = 101.173(7)°, V = 1347.83(12) Å3, and Z = 2. Hydroredmondite is monoclinic, P21/n, a = 12.5991(9), b = 9.2819(4), c = 12.9774(9) Å, β = 90.443(6)°, V = 1517.57(16) Å3, and Z = 2. Sulfatoredmondite is monoclinic, C2/m, a = 17.294(2), b = 7.3668(9), c = 12.7271(18) Å, β = 110.622(9)°, V = 1517.5(4) Å3, and Z = 2. The crystal structures of redmondite (R1 = 0.0346 for 2061 I &gt; 2σI), hydroredmondite (R1 = 0.0346 for 3022 I &gt; 2σI), and sulfatoredmondite (R1 = 0.0344 for 1661 I &gt; 2σI) are all based on the same [Pb8O2Zn(OH)6]8+ structural unit.
Importancia de la vinculación social, extensión, investigación y movilidad en el marco procesos de aseguramiento de la calidad
Authors: Blanes González María Luisa , Llamosas Quintana Elda Juliana 
Published: March 2023

La importancia de la experiencia académica de vinculación social de actividades de investigación, extensión y movilidad trasciende con los procesos de aseguramiento de calidad, siendo el objetivo los procesos de integración regional y los proyectos realizados. La metodología aplicada de enfoque mixto con énfasis cualitativo, descriptivo para el desarrollo de estrategias académicas, propician la vinculación social de los trabajos de investigacion y extensión. El logro es el relacionamiento entre ambas actividades ante la demanda de la sociedad en la que se insertan los nuevos profesionales y en miras al logro de la vinculación y proyección social. La relevancia de este trabajo es la implementación de proyectos sociales participativos, la formación de equipos académicos multidisciplinarios de docentes estudiantes y egresados en base a proyectos de vinculación nacional e internacionalización, aplicados mediante alianzas formalizadas y convenios vigentes del ámbito universitario tanto de la FADA UNA Universidad Nacional como en la Universidad Americana de Asunción en la cual, venimos también incidiendo para la transformación de realidades sociales mediante la articulación de funciones sustantivas y la implementación de Redes Universitarias como mecanismos de cooperación en el marco de los procesos de Aseguramiento de la Calidad.
La boxe à travers la presse (Espagne, Mexique, XIXe siècle) : l’homo americanus en « guantes como fórmula de civilización»
Authors: Sablonnière  Catherine 
Published: March 2023

La boxe, sport populaire en Angleterre puis aux États-Unis au XIXe siècle, est vue dans la presse espagnole et mexicaine de la fin du siècle comme l’expression de la civilisation matérielle anglo-saxonne qui se teinte de la violence qu’incarne le combat, dans le contexte de l'antagonisme entre Espagne, Mexique et États-Unis pour le contrôle des territoires du continent américain. La force des poings semble être le caractère distinctif de la manière de faire de la politique en Angleterre et aux États-Unis. Dénigrée pour la déshumanisation des combattants qu’elle implique, les désordres sociaux et moraux qu’elle alimente, la boxe conquiert peu à peu une certaine autonomie grâce aux récits de combats qui suscitent une nouvelle créativité langagière. La description du corps musclé du boxeur américain statufie un nouveau type d’« homo americanus » dans lequel se reconnaissent les nord-américains et suscite fascination et rejet, de manière assez homogène, dans les articles des chroniqueurs mexicains et espagnols, conscients de l’enjeu culturel et politique que représente l’acceptation de la boxe comme sport civilisé.
Un exemple de soft power français en Amérique du Sud : le cas du département d’histoire de l’Université de São Paulo.
Authors: Kinsella Coutinho Arianna 
Published: March 2023

L'objet de cet article est de présenter la diplomatie culturelle française au Brésil au début du XXème siècle comme un exemple réussi de soft power. Grâce à la présence des universitaires français pendant les premières années d’existence de l’Université de São Paulo (USP), la France a laissé une empreinte indélébile dans le savoir-faire universitaire notamment en matière de discipline historique et a façonné les goûts des élites intellectuelles locales. Au moyen des liens entretenus depuis cette époque fondatrice entre universitaires français et ceux de l’USP, la France a pu ancrer l’universalisme républicain dans l’esprit des futurs historiens brésiliens. L’histoire brésilienne est devenue une discipline clé dont le savoir-faire est déterminant pour la construction de l’identité nationale.
Approche comparative de l’occupation des sites de hauteur en Auvergne (Bronze final III/premier âge du Fer et Antiquité tardive/haut Moyen Âge) : chronologie, formes, dynamiques spatiales et paysagères à l’échelle d’un territoire
Authors: Delrieu Fabien , Dendievel André-Marie , Martinez Damien 
Published: March 2023

Cet article propose de confronter les résultats de recherches archéologiques et paléoenvironnementales en cours sur l’occupation des sites de hauteur en Auvergne à deux moments-clés : d’une part, au cours de la Protohistoire ancienne (âge du Bronze final III et premier âge du Fer) et, d’autre part, de l’Antiquité tardive et du haut Moyen Âge. Ces deux périodes paraissent chacune marquées par un investissement significatif des zones de moyenne montagne. Ce premier bilan a été l’occasion de développer un dialogue étroit et pérenne entre spécialistes. Les objectifs de ce travail pluridisciplinaire sont de mettre en lumière les points communs et les divergences perceptibles dans les modalités d’investissement des points hauts durant ces deux séquences chronologiques ainsi que d’appréhender les dynamiques spatiales et paysagères à l’échelle d’un territoire.
Favoriser les activités d’orientation des conseillers en Mission Locale avec l’application-web DiagOriente
Authors: Reyssier Stéphanie Dumas , Touraille Christel 
Published: March 2023

Les Missions Locales ont pour vocation de faciliter l’orientation et l’insertion socio-professionnelle des jeunes de 16 à 25 ans. Les conseillers·ères qui les suivent, sont aidé·es dans leurs missions par divers outils numériques dont l’application-web DiagOriente qui vise à valoriser les compétences transverses à partir des expériences professionnelles et centres d’intérêts. L’objet de cet article est d’identifier, à partir de cinq entretiens semi-directifs et d’une méthode mise au point précédemment (Reyssier, 2020 ; Touraille & Simonian, 2022), si cette application est « affordante » (Gibson, 1979 ; Simonian, 2022), c’est à dire si elle est perçue immédiatement comme permettant de faciliter l’accompagnement à l’orientation des jeunes. Les résultats montrent que l’orientation est facilitée par cet outil numérique, qui prend en charge une partie de la tâche de guidage de la réflexion des jeunes. Ce gain de temps et de disponibilité offrirait de nouvelles affordances : une individualisation du soutien et/ou la création de nouveaux ateliers collectifs.
CARD19, a Novel Regulator of the TAK1/NF-κB Pathway in Self-Reactive B Cells
Authors: Zheng Yongwei , Yu Mei , Chen Yuhong , Xue Liquan , Zhu Wen , Fu Guoping , Morris Stephan W , Wen Renren , Wang Demin 
Published: March 2023

Abstract
The caspase recruitment domain family member (CARD)11-Bcl10-Malt1 signalosome controls TGF-β–activated kinase 1 (TAK1) activation and regulates BCR-induced NF-κB activation. In this study, we discovered that CARD19 interacted with TAK1 and inhibited TAB2-mediated TAK1 ubiquitination and activation. Although CARD19 deficiency in mice did not affect B cell development, it enhanced clonal deletion, receptor editing, and anergy of self-reactive B cells, and it reduced autoantibody production. Mechanistically, CARD19 deficiency increased BCR/TAK1-mediated NF-κB activation, leading to increased expression of transcription factors Egr2/3, as well as the E3 ubiquitin ligases c-Cbl/Cbl-b, which are known inducers of B cell tolerance in self-reactive B cells. RNA sequencing analysis revealed that although CARD19 deficiency did not affect the overall Ag-induced gene expression in naive B cells, it suppressed BCR signaling and increased hyporesponsiveness of self-reactive B cells. As a result, CARD19 deficiency prevented Bm12-induced experimental systemic lupus erythematosus. In summary, CARD19 negatively regulates BCR/TAK1-induced NF-κB activation and its deficiency increases Egr2/3 and c-Cbl/Cbl-b expression in self-reactive B cells, thereby enhancing B cell tolerance.
mTOR Activation Underlies Enhanced B Cell Proliferation and Autoimmunity in PrkcdG510S/G510S Mice
Authors: Moreews Marion , Mathieu Anne-Laure , Pouxvielh Kevin , Reuschlé Quentin , Drouillard Annabelle , Dessay Pénélope , Meignien Marie , Zhang Jiang , Fallone Lucie , Rousseaux Noëmi , Ainouze Michelle , Rey Amaury , Omarjee Ommar , Decembre Elodie , Lenief Vanina , Djebali Sophia , Thaunat Olivier , Dreux Marlène , Genestier Laurent , Defrance Thierry , Soulas-Sprauel Pauline , Marçais Antoine , Walzer Thierry , Belot Alexandre 
Published: March 2023

Abstract
Autosomal recessive PRKCD deficiency has previously been associated with the development of systemic lupus erythematosus in human patients, but the mechanisms underlying autoimmunity remain poorly understood. We introduced the Prkcd G510S mutation that we previously associated to a Mendelian cause of systemic lupus erythematosus in the mouse genome, using CRISPR-Cas9 gene editing. PrkcdG510S/G510S mice recapitulated the human phenotype and had reduced lifespan. We demonstrate that this phenotype is linked to a B cell–autonomous role of Prkcd. A detailed analysis of B cell activation in PrkcdG510S/G510S mice shows an upregulation of the PI3K/mTOR pathway after the engagement of the BCR in these cells, leading to lymphoproliferation. Treatment of mice with rapamycin, an mTORC1 inhibitor, significantly improves autoimmune symptoms, demonstrating in vivo the deleterious effect of mTOR pathway activation in PrkcdG510S/G510S mice. Additional defects in PrkcdG510S/G510S mice include a decrease in peripheral mature NK cells that might contribute to the known susceptibility to viral infections of patients with PRKCD mutations.
‘Maids are Stressful but Indispensable’ : Experiences of Employers of Domestic Workers
Authors: Hapazari Josphine , Matobo Thope A. 
Published: March 2023

The study explores career women’s experiences and seeks to understand their predicament in their daily interactions with domestic workers. It also highlights the tensions between employers and employees, given that they belong to different economic worlds. Domestic workers have a high turnover which frustrates their employers, who then find it difficult to increase wages to acceptable rates beyond the stated amounts. Drawing from in-depth interviews with 14 employers of domestic workers, this qualitative study explores the experiences of these employers utilising the National University of Lesotho as the research site. The study confirmed the interdependence of employers and domestic workers. The study also unearthed that the employment relationship between employers and domestic workers is complex and often crammed with mistrust, ill-treatment, and stress, but also relief and support. There is a need for the Lesotho government to monitor domestic work policies to avoid exploitation and abuse, which prevail in the interrelationship of employers and employees in this sector.
Post-transitional Justice in Nigeria and the Igbo Nationalism Question
Authors: Odubajo Tola 
Published: March 2023

The 1990s saw the resurgence of transitional justice as a mechanism for reconciling groups and individuals in hitherto authoritarian and undemocratic states. The former military-governed states and post-conflict states in Africa adopted a truth commission approach to transitional justice and latched on to the window of opportunity that could engender new beginnings. Nigerians generally applauded the initiative of the Obasanjo civilian administration (1999-2007) of setting up a Truth Commission to investigate the human rights violations against individuals and groups between 1966 and 1999. With the aid of secondary data, this article adopts the descriptive and historical methodological approaches to interrogate the fissiparous tendencies of the Igbo ethnic nationality in Nigeria. The article employs content analysis to examine the variables that induced both the selfdetermination drive of the Igbo and the responses of the Nigerian government between 1999 and 2018. The work investigates the nexus in the activities of the two prominent separatist revival groups - the Movement for the Actualisation of the Sovereign State of Biafra (MASSOB) and the Indigenous People of Biafra (IPOB) - and the Nigerian state, against the backdrop of the recommendations of the Truth Commission. The government’s inability to negotiate the implementation of the recommendations of the Truth Commission, and therefore redress the perceived historical injustices to the Igbo, resulted in continued exclusion, marginalisation and peripheralization of the Igbo in the Nigerian state.
Analysis of India’s Non-State-Owned Enterprise Investments in Africa: An Empirical Approach
Authors: Bhatnagar Ankur 
Published: March 2023

This paper focuses on Indian foreign direct investment (FDI) flows to Africa for the period 2008 to 2018, amidst increasing state efforts to improve Indo- African economic ties. This study pioneers the segregation of investments led by state-owned enterprises (SOEs) from non-SOEs in an empirical analysis. The motivation is rooted in the scarcity of empirical evidence of Indian FDI in Africa, particularly by non-SOEs. The random effects model was applied on the panel data for 2008-18 to highlight the significant causative effect of country alliances, gross domestic product (GDP) and net overseas development assistance of host countries in attracting greater FDI from Indian enterprises. The effect of corruption levels remains less clear in a statistical sense. These results could inform the political and economic policies of African host countries that seek financial and technical support from India.