bluuebunny/crossref_metadata_2025_split huggingface dataset:
A novel defined pyroptosis-related gene signature predicts prognosis and correlates with the tumour immune microenvironment in lung adenocarcinoma
Authors: Chen Zi , Ge Linyang , Xu Shuanglan , Li Qin , Zhou Linfu 
Published: June 2023

AbstractLung adenocarcinoma (LUAD) is one of the most common causes of cancer-related death. The role of pyroptosis in LUAD remains unclear. Our study aimed to identify a prognostic signature of pyroptosis-related genes (PRGs) and explore the connection of PRGs with the tumour microenvironment in LUAD. Gene expression and clinical information were obtained from The Cancer Genome Atlas database. Consensus clustering was applied to classify LUAD patients. The least absolute shrinkage and selection operator Cox and multivariate Cox regression models were used to generate a PRG-related prognostic signature. The correlations between PRGs and tumour-infiltrating immune cells or the tumour mutational burden were analysed by Spearman’s correlation analysis. In this study, 44 PRGs significantly differed in expression between LUAD and normal tissues. Based on these genes, patients were clustered into three clusters with significantly different distributions of tumour-infiltrating immune cells and immune checkpoint regulators. A total of four PRGs (NLRP1, HMGB1, CYCS, and BAK1) were used to construct a prognostic model. Significant correlations were observed between these prognostic PRGs and immune cell infiltration or the tumour mutational burden. Predictive nomogram results showed that BAK1 could be an independent prognostic biomarker in LUAD. Additionally, the expression level of BAK1 was validated in two independent Gene Expression Omnibus cohorts. Our identified prognostic PRG signature may provide insight for future studies targeting pyroptosis and the tumour microenvironment in LUAD. Future studies are needed to verify our current findings.
Neural correlates of visual and tactile path integration and their task related modulation
Authors: Rosenblum Lisa , Kreß Alexander , Arikan B. Ezgi , Straube Benjamin , Bremmer Frank 
Published: June 2023

AbstractSelf-motion induces sensory signals that allow to determine travel distance (path integration). For veridical path integration, one must distinguish self-generated from externally induced sensory signals. Predictive coding has been suggested to attenuate self-induced sensory responses, while task relevance can reverse the attenuating effect of prediction. But how is self-motion processing affected by prediction and task demands, and do effects generalize across senses? In this fMRI study, we investigated visual and tactile self-motion processing and its modulation by task demands. Visual stimuli simulated forward self-motion across a ground plane. Tactile self-motion stimuli were delivered by airflow across the subjects’ forehead. In one task, subjects replicated a previously observed distance (Reproduction/Active; high behavioral demand) of passive self-displacement (Reproduction/Passive). In a second task, subjects travelled a self-chosen distance (Self/Active; low behavioral demand) which was recorded and played back to them (Self/Passive). For both tasks and sensory modalities, Active as compared to Passive trials showed enhancement in early visual areas and suppression in higher order areas of the inferior parietal lobule (IPL). Contrasting high and low demanding active trials yielded supramodal enhancement in the anterior insula. Suppression in the IPL suggests this area to be a comparator of sensory self-motion signals and predictions thereof.
Taming Fabry–Pérot resonances in a dual-metasurface multiband antenna with beam steering in one of the bands
Authors: Gonçalves Licursi de Mello Rafael , Lepage Anne Claire , Begaud Xavier 
Published: June 2023

AbstractMetasurfaces are artificial materials that can provide properties not readily available in nature for the interaction with acoustic, elastodynamic, or electromagnetic waves. In Electromagnetics, metasurfaces allow particular functionalities to antennas, which in turn lately have been increasingly pushed to a multiband operation. To fully exploit metasurfaces’ capabilities, the use of a metasurface reflector and a metasurface superstrate surrounding a radiating element in multiband antennas is interesting. However, such topology generally creates multiple reflections inside the formed cavity, known as Fabry–Pérot resonances. Here we show that one should tame this phenomenon to use two parallel metasurfaces surrounding a planar radiating element. We present the conditions to obtain directive, multiband antennas under such circumstances. The concepts are validated with a compact device for 5G/4G/Wi-Fi 2.4/5/6E performing a beam steering in the 5G without disturbing the radiation patterns of the other bands. This device demonstrates that the functionalities of two metasurfaces may be exploited in a single design if the presented conditions are respected. We also anticipate our work to be a starting point for other studies in the wave domain. For example, compact, multiband, beam-steerable microphones or sonar transducers with two parallel metasurfaces could be investigated in the future.
Match running performance profiles of amputee football players at the national level
Authors: Muracki Jarosław , Nowak Michał , Kawczyński Adam , Silva Ana Filipa , Clemente Filipe Manuel 
Published: June 2023

AbstractEven though running performance and positional profiles in football are well described, amputee football (AF) has different characteristics of the movement, pitch dimensions, and time played. There is a gap in the scientific literature about positional profiles based on running performance in AF. This study aimed to investigate the differences between positions, the influence of the amputation level or defect of the lower limb (LD), the differences in running performance between halves, and the relationship with the final match result. Thirteen AF National Team players were monitored by Global Navigation Satellite System (GNSS), tracking 24 official international matches for 17 months. Values of top speed, peak acceleration, peak deceleration, average distance per minute, sprint mean speed, GPS load per minute, inertial load per minute (Gs load/min), number of sprints per minute, and a number of impacts per minute were analyzed for defenders (DEF), midfielders (MID) and forwards (FOR). Additional factors analyzed were amputation level (below the knee, low amputation—LA or over the knee, high amputation—HA or defect of the lower limb—LD) and the match's final result. Midfielders had significantly higher running performance parameters compared to other positions (greater top speed than DEF (+ 0.3 m/s; p < 0.001) and FOR (+ 0.2 m/s; p = 0.045), greater peak acceleration and deceleration than DEF (+ 0.5 m/s2 for both measures; p < 0.001) and FOR (+ 0.4 and + 0.3 m/s2; p < 0.001 and p = 0.036, respectively), greater GPS load/minute than DEF (+ 0.2 load/min; p = 0.001) and FOR (+ 0.3 load/min; p < 0.001), greater Gs load per minute than DEF (+ 2.7 load/min; p < 0.001) and FOR (+ 1.8 load/min; p < 0.001), greater number of impacts per minute than DEF (+ 0.2 n/min; p < 0.001) and FOR (+ 0.2 n/min; p < 0.001). Players with LD had significantly higher running performance than those with LA or HA. In the match's second half, a decrease in running performance was registered. The trend of running more when losing could be observed—AF players had higher running parameters in lost matches, but the differences were not statistically significant. Further research complied with contextual game analysis is needed to assess the running performance of AF players deeply.
Influence of rubber’s viscoelasticity and damping on vertical dynamic stiffness of air spring
Authors: Hu Yinghao , Zhang Jianhong , Long Jiangqi 
Published: June 2023

AbstractUsing the diaphragm-type air spring as the research object. The ratio of the vertical stiffness change caused by compressed air to the total vertical stiffness change was calculated, and it was determined that the nonlinearity of air spring vertical stiffness was mainly caused by the deformation stiffness of the rubber airbag. The variation law of vertical dynamic stiffness of air spring was predicted by theory: due to the material's viscoelasticity, the vertical dynamic stiffness rises as the excitation frequency rises, and the vertical dynamic stiffness decreases with the increase of excitation amplitude due to the damping of the material. An air spring finite element analysis (FEA) and experiment were conducted. The results show that the vertical dynamic stiffness obtained through simulation and experiment is consistent with the theoretical prediction, when various factors such as material nonlinearity, element coupling, and stiffness value sensitivity were considered. This proves that the predicted vertical dynamic stiffness variation law is reliable. The vertical dynamic stiffness obtained from both simulation and experiment showed a strong correlation in numerical values, which verified the accuracy of the FEA model of air spring established in this paper.
Probability density function for random photon steps in a binary (isotropic-Poisson) statistical mixture
Authors: Binzoni Tiziano , Mazzolo Alain 
Published: June 2023

AbstractMonte Carlo (MC) simulations allowing to describe photons propagation in statistical mixtures represent an interest that goes way beyond the domain of optics, and can cover, e.g., nuclear reactor physics, image analysis or life science just to name a few. MC simulations are considered a “gold standard” because they give exact solutions (in the statistical sense), however, in the case of statistical mixtures their implementation is often extremely complex. For this reason, the aim of the present contribution is to propose a new approach that should allow us in the future to simplify the MC approach. This is done through an explanatory example, i.e.; by deriving the ‘exact’ analytical expression for the probability density function of photons’ random steps (single step function, SSF) propagating in a medium represented as a binary (isotropic-Poisson) statistical mixture. The use of the SSF reduces the problem to an ‘equivalent’ homogeneous medium behaving exactly as the original binary statistical mixture. This will reduce hundreds MC simulations, allowing to obtain one set of wanted parameters, to only one equivalent simple MC simulation. To the best of our knowledge the analytically ‘exact’ SSF for a binary (isotropic-Poisson) statistical mixture has never been derived before.
Spatio-temporal evolution of eutrophication and water quality in the Turawa dam reservoir, Poland
Authors: Buta Bogna , Wiatkowski Mirosław , Gruss Łukasz , Tomczyk Paweł , Kasperek Robert 
Published: June 2023

AbstractThe objectives of the article are: to assess spatio-temporal evolution of eutrophication and water quality of the Turawa dam reservoir, located in south-western Poland on the Mała Panew River; to identify location and relationship between potential sources of physicochemical pollution related to the progressing process of eutrophication; and to determine trophic status and water quality indices of the selected research object. The analysis (Mann–Whitney U test, PCA, HCA, Spearman correlation matrix) showed a high susceptibility of the reservoir to eutrophication processes, especially due to the influence of dangerous loads of compounds emerging from areas with high tourist intensity and pollutants flowing from the Mała Panew River. The parameters deteriorating the ecological status were TP, DO, BOD5, and COD. Considering the cumulative results of water quality indices for the period 1998–2020, the average water quality was in classes II or III. A noticeable deterioration appeared in water quality for the years 2016–2020, which proves the progressing eutrophication in the Turawa reservoir. In 1998–2020, the reservoir was classified as eutrophic or mesoeutrophic based on the calculated three trophic status indices. This article would help in developing a strategy for dealing with water blooms, a reliable system for monitoring pressures causing eutrophication, and optimal technologies for the reconstruction of multifunctional reservoirs.
Distrust as a form of inequality
Authors: Kubota Jennifer T. , Venezia Samuel A. , Gautam Richa , Wilhelm Andrea L. , Mattan Bradley D. , Cloutier Jasmin 
Published: June 2023

AbstractNavigating social hierarchies is a ubiquitous aspect of human life. Social status shapes our thoughts, feelings, and actions toward others in various ways. However, it remains unclear how trust is conferred within hierarchies and how status-related cues are used when resources are on the line. This research fills this knowledge gap by examining how ascribed, consensus-based status appearance, and perceived status appearance impact investment decisions for high- and low-status partners during a Trust Game. In a series of pre-registered experiments, we examined the degree to which participants trusted unfamiliar others with financial investments when the only available information about that person was their socioeconomic status (SES). In Study 1, SES was ascribed. Studies 2 and 3 conveyed SES with visual antecedents (clothing). Across all three experiments, participants trusted high SES partners more than low SES partners. In addition, subjective perceptions of status based on visual cues were a stronger predictor of trust than consensus-based status judgments. This work highlights a high status-trust bias for decisions where an individual’s money is on the line. In addition, high-status trust bias may occur simply because of an individual’s subjective assumptions about another’s rank.
Serological response following COVID-19 vaccines in patients living with HIV: a dose–response meta-analysis
Authors: Zhou Qian , Zeng Furong , Meng Yu , Liu Yihuang , Liu Hong , Deng Guangtong 
Published: June 2023

AbstractTo quantify the pooled rate and risk ratio of seroconversion following the uncomplete, complete, or booster dose of COVID-19 vaccines in patients living with HIV. PubMed, Embase and Cochrane library were searched for eligible studies to perform a systematic review and meta-analysis based on PRIMSA guidelines. The pooled rate and risk ratio of seroconversion were assessed using the Freeman-Tukey double arcsine method and Mantel–Haenszel approach, respectively. Random-effects model was preferentially used as the primary approach to pool results across studies. A total of 50 studies involving 7160 patients living with HIV were analyzed. We demonstrated that only 75.0% (56.4% to 89.9%) patients living with HIV achieved a seroconversion after uncomplete vaccination, which improved to 89.3% (84.2% to 93.5%) after complete vaccination, and 98.4% (94.8% to 100%) after booster vaccination. The seroconversion rates were significantly lower compared to controls at all the stages, while the risk ratios for uncomplete, complete, and booster vaccination were 0.87 (0.77 to 0.99), 0.95 (0.92 to 0.98), and 0.97 (0.94 to 0.99), respectively. We concluded that vaccine doses were associated with consistently improved rates and risk ratios of seroconversion in patients living with HIV, highlighting the significance of booster vaccination for patients living with HIV.
First-principles study on the electronic and optical properties of AlSb monolayer
Authors: Mohebpour Mohammad Ali , Tagani Meysam Bagheri 
Published: June 2023

AbstractUsing density functional theory and many-body perturbation theory, we systematically investigate the optoelectronic properties of AlSb monolayer, which has been recently synthesized by molecular beam epitaxy [ACS Nano 2021, 15, 5, 8184–8191]. After confirming the dynamical stability of the monolayer, we analyze its electronic properties at different levels of theory without (PBE, HSE03, HSE06) and with (G$$_0$$

0

W$$_0$$

0

, GW$$_0$$

0

, and GW) electron-electron interaction. The results show that AlSb monolayer is a semiconductor with a direct quasiparticle band gap of 1.35 eV while its electronic structure is dominated by spin-orbit coupling. Also, we study the optical properties of the monolayer by solving the Bethe–Salpeter equation. In this regard, the effects of spin-orbit coupling, electron–electron correlation, and electron–hole interaction on the optical spectrum of the monolayer are evaluated. Based on the highest level of theory, the first bright exciton is found to be located at 0.97 eV, in excellent agreement with the experimental value (0.93 eV). Moreover, the exciton binding energy, effective mass, and Bohr radius are obtained 0.38 eV, 0.25 m$$_0$$

0

, and 6.31 Å, respectively. This work provides a better understanding of the electronic, optical, and excitonic properties of AlSb monolayer and may shed light on its potential applications.
Neural bases of reward anticipation in healthy individuals with low, mid, and high levels of schizotypy
Authors: Carruzzo F. , Giarratana A. O. , del Puppo L. , Kaiser S. , Tobler P. N. , Kaliuzhna M. 
Published: June 2023

AbstractA growing body of research has placed the ventral striatum at the center of a network of cerebral regions involved in anticipating rewards in healthy controls. However, little is known about the functional connectivity of the ventral striatum associated with reward anticipation in healthy controls. In addition, few studies have investigated reward anticipation in healthy humans with different levels of schizotypy. Here, we investigated reward anticipation in eighty-four healthy individuals (44 females) recruited based on their schizotypy scores. Participants performed a variant of the Monetary Incentive Delay Task while undergoing event-related fMRI.Participants showed the expected decrease in response times for highly rewarded trials compared to non-rewarded trials. Whole-brain activation analyses replicated previous results, including activity in the ventral and dorsal striatum. Whole-brain psycho-physiological interaction analyses of the left and right ventral striatum revealed increased connectivity during reward anticipation with widespread regions in frontal, parietal and occipital cortex as well as the cerebellum and midbrain. Finally, we found no association between schizotypal personality severity and neural activity and cortico-striatal functional connectivity. In line with the motivational, attentional, and motor functions of rewards, our data reveal multifaceted cortico-striatal networks taking part in reward anticipation in healthy individuals. The ventral striatum is connected to regions of the salience, attentional, motor and visual networks during reward anticipation and thereby in a position to orchestrate optimal goal-directed behavior.
A novel hermit crab optimization algorithm
Authors: Guo Jia , Zhou Guoyuan , Yan Ke , Shi Binghua , Di Yi , Sato Yuji 
Published: June 2023

AbstractHigh-dimensional optimization has numerous potential applications in both academia and industry. It is a major challenge for optimization algorithms to generate very accurate solutions in high-dimensional search spaces. However, traditional search tools are prone to dimensional catastrophes and local optima, thus failing to provide high-precision results. To solve these problems, a novel hermit crab optimization algorithm (the HCOA) is introduced in this paper. Inspired by the group behaviour of hermit crabs, the HCOA combines the optimal search and historical path search to balance the depth and breadth searches. In the experimental section of the paper, the HCOA competes with 5 well-known metaheuristic algorithms in the CEC2017 benchmark functions, which contain 29 functions, with 23 of these ranking first. The state of work BPSO-CM is also chosen to compare with the HCOA, and the competition shows that the HCOA has a better performance in the 100-dimensional test of the CEC2017 benchmark functions. All the experimental results demonstrate that the HCOA presents highly accurate and robust results for high-dimensional optimization problems.
Paraoxonase 2 (PON2) plays a limited role in murine lung tumorigenesis
Authors: Whitt Aaron G. , Neely Aaron M. , Sarkar Omar Sadi , Meng Shuhan , Arumugam Sengodagounder , Yaddanapudi Kavitha , Li Chi 
Published: June 2023

AbstractParaoxonase 2 (PON2) is a multifunctional intracellular enzyme that has received growing attention for its ability to modulate various aspects of normal and malignant cellular physiology. Recent research has revealed that PON2 is upregulated in tissues from patients with various types of solid tumors and hematologic cancers, likely due to its ability to suppress oxidative stress and evade apoptosis. However, the effects of PON2 on pulmonary oncogenesis are unknown. Here, we conducted studies to investigate how PON2 influences lung cancer cell proliferation in vitro and lung tumorigenesis in vivo using a variety of cellular and animal models. It was found that PON2 expression deficiency hampered the proliferation of cultured lung cancer cells with concomitant cell cycle arrest at the G1 phase. In addition, the loss of endogenous PON2 expression impaired key aspects of oxidative metabolism in lung adenocarcinoma cells. Moreover, we investigated how the interplay between PON2 expression in lung tumors and host mice influences lung tumor initiation and progression. PON2 status in both transplanted tumor cells and mice failed to influence the development of subcutaneously grafted Lewis lung carcinoma (LLC) tumors, orthotopically implanted LLC tumors, and oncogenic Kras-driven primary lung adenocarcinoma tumors. Importantly, the frequencies of tumor-infiltrating myeloid subsets that include myeloid-derived suppressor cells (MDSCs) and tumor-associated macrophages were not impacted by PON2 expression in LLC tumor-bearing mice. Overall, our studies indicate that PON2 plays a limited role in murine lung tumorigenesis.
Second harmonic generation on crystalline organic nanoclusters under extreme nanoconfinement in functionalized silica–benzil composites
Authors: El Karout Houda , Shchur Yaroslav , Andrushchak Anatoliy , Sahraoui Bouchta , Wielgosz Robert , Kityk Olha , Jędryka Jarosław , Slyvka Yurii , Kityk Andriy V. 
Published: June 2023

AbstractWe demonstrate a series of organic–inorganic nanocomposite materials combining the mesoporous silica (PS) and benzil (BZL) nanocrystals embedded into its nanochannels (6.0–13.0 nm in diameter) by capillary crystallization. One aims to design novel, efficient nonlinear optical composite materials in which inactive amorphous host PS-matrix provides a tubular scaffold structure, whereas nonlinear optical functionality results from specific properties of the deposited guest BZL-nanocrystals. A considerable contraction of the BZL melt during its crystallization inside the silica nanochannels results in a formation of the texture consisting of (221)- and (003)-oriented BZL nanoclusters (22 nm in length), separated by voids. Specificity of the textural morphology similarly to the spatial confinement significantly influences the nonlinear optical features of composite PS:BZL materials being explored in the second harmonic generation (SHG) experiment. The light polarization anisotropy of the SHG response appears to be considerably reduced at channel diameters larger than 7 nm apparently due to the multiple scattering and depolarization of the light on randomly distributed and crystallographically oriented BZL-nanoclusters. The normalized SHG response decreases nonlinearly by more than one order of magnitude as the channel diameter decreases from 13.0 to 6.0 nm and vanishes when spatial cylindrical confinement approaches the sizes of a few molecular layers suggesting that the embedded BZL clusters indeed are not uniformly crystalline but are characterized by more complex morphology consisting of a disordered SHG-inactive amorphous shell, covering the channel wall, and SHG-active crystalline core. Understanding and controlling of the textural morphology in inorganic–organic nanocrystalline composites as well as its relationships with nonlinear optical properties can lead to the development of novel efficient nonlinear optical materials for the light energy conversion with prospective optoelectronic and photonic applications.