bluuebunny/crossref_metadata_2025_split huggingface dataset:
The society of Information and the European citizens’ perception of climate change: natural or anthropological causes
Authors: Mata Fernando , Dos-Santos Maria , Cano-Díaz Concha , Jesus Meirielly , Vaz-Velho Manuela 
Published: August 2023

Abstract
The scientific community has reached a consensus on humans’ important role as causative agents of climate change; however, branches of society are still skeptical about this. Climate change is a key issue for humanity and only the commitment to change human attitudes and lifestyles, at the global level, can be effective in its mitigation. With this purpose, it is important to convey the right message and prevent misinformation to manipulate people’s minds. The present study aims to understand the factors shaping European citizens’ thoughts on the causes of climate change. Using data from the European Social Survey 10 collected in 2022, we fitted statistical models using the people’s thoughts on causes of climate change (natural, anthropogenic, or both) as dependent variables. As independent variables, we used the impact of the media through time spent on news and time spent on the internet, level of education, the level of trust in scientists, awareness of online or mobile misinformation, and gender. We concluded that the typical European citizen that believes in anthropogenic causes of climate change is a female, is more literate, trusts more in scientists, is younger, spends more time reading the news, and has more awareness of misinformation presence in online and mobile communications.
Mobile Anti-Theft and Privacy Protection Framework using Blockchain
Authors: Dubey Shivam , Eswari R. , Vamshi A. 
Published: August 2023

Abstract
It is impossible to imagine our lives with smart phones or mobile devices. Mobile phones are not just a means for communication today, people use mobile phone devices for entertainment as well as business. We store sensitive data in our smart phones, perform digital transactions and lot of other things. Due to the portable nature, these mobile devices are easy to be stolen or lost. Since these devices are an integral part of our life and contains sensitive personal and business data, it is very important to prevent their theft. There are several solutions available to prevent the mobile theft, but they have some limitations like data security, leakage of personal information or misuse of data by a malicious third party. In order to overcome these limitations, we propose a blockchain based mobile theft prevention system. The proposed solution uses blockchain and smart contracts for authentication, storing user data and tracking of mobile device. By introducing the blockchain in the system, we make it much more secure from user’s privacy and security point of view. The proposed system not only provides security and privacy to the user but also a platform to make the sale/purchase of the device and transfer the ownership to the other user as well.
Efficacy of active and passive virtual reality distraction during local anesthesia in children
Authors: Mohammed Oula Kara , Raslan Nabih 
Published: August 2023

Abstract

Objective
The aim of this study is to compare active distraction (playing video games) and passive distraction (watching cartoon videos) using a Virtual Reality (VR) device, in reducing pain associated with local anesthesia injection in children.
Materials and methods
This double-blind RCT included 82 healthy children (6–10 years old) who were divided equally into active distraction (AD) and passive distraction (PD) groups. Pain was assessed during and after the IANB injection using Wong-Baker FACES ® pain rating scale (WBF), Faces, Legs, Activity, Cry, Consolability (FLACC) Behavioral Pain Rating Scale, and heart rate (HR) monitoring. Mann-Whitney U and t-tests were used to achieve the statistical analysis.
Results
Injection-related pain assessment showed converging values for the two types of distraction where there were no significant differences between AD and PD groups according to subjective (P = 0.372 ˃ 0.05), and behavioral (P = 0.439 ˃ 0.05) scales. The HR changes (The difference between the highest HR value during the injection and the baseline HR value) showed no significant differences between the study groups (P = 0.245 ˃ 0.05).
Conclusion
The VR device reduces pain during local anesthesia in cooperative children regardless of the type of distraction with little advantage for active distraction over passive distraction.
Clinical significance:
The use of the VR device on children is considered an effective, safe, and non-pharmacological distraction technique.
Trial registration
Clinicaltrials, NCT05129943, (https://clinicaltrials.gov/ct2/show/NCT05129943).
IMFD: The first online database of documentation on Marine fungi from India
Authors: KR Ranadive , BD Borse , DJ Bhat , KN Borse , AR Tuwar , NS Pawar , H Khare , N Jagtap 
Published: August 2023

Abstract

The Indian Marine Fungal Database (IMFD) is the first on-line database of information on Marine fungi from India. The database contains 233 records from 52 families, 146 genera and 233 species, and can be accessed at www.fungifromindia.com. Every species from this industrially important group of fungi has been given a unique identity number that can be cited in publications where a new species is described. Every entry in this database has been linked with the globally recognized myco-database (www.mycobank.org). The IMFD is part of an Indian initiative to promote international biodiversity documentation and form a global network of databases on biological information.
Ursolic acid alleviates cholestasis by regulating Nrf2- UGT2B7/BSEP/MRP2 pathway in vivo and in vitro
Authors: Wang Xing , Xiong Wenqiang , Wang Xin , Qin Liying , Zhong Maolian , Liu Yan , Xiong Yuqing , Yi Xiaoyi , Wang Xiaosong , Zhang Hong 
Published: August 2023

Abstract
Human hepatoblastoma cell line HepG2 has been widely used in the study of liver and liver cancer. α-naphthyl-isothiocyanate (ANIT) is a poison widely used in rodents to simulate human intrahepatic cholestasis. Ursolic acid (UA), a pentacyclic triterpenoid, exhibits various pharmacological actions. However, the role of nuclear factor E2 related factor 2 (Nrf2)-uridine diphosphate glucuronosyltransferase (UGT2B7)/bile salt output pump (BSEP)/multidrug resistance-associated protein 2 (MRP2) pathway in UA against cholestatic liver injury has not been cleared. The purpose of this study is to explore the effect of UA on cholestatic liver injury and its potential mechanism. Compared with the control group, UA could increase the expression of Nrf2, UGT2B7, BSEP, and MRP2 in HepG2 cells by Rt-qPCR and Western Blot. This up-regulation was inhibited after silencing Nrf2. The results of pathological sections and biochemical indexes showed that UA could alleviate cholestatic liver injury induced by ANIT and significantly activate the mRNA and protein of UGT2B7, BSEP, and MRP2 in liver tissue. However, this activation was inhibited in rats silenced with Nrf2. We confirmed that UA can reduce cholestasis. And it's related to Nrf2-UGT2B7/BSEP/MRP2. Therefore, this study expands the understanding of the anti-cholestatic effect of UA and provides a new therapeutic target for cholestasis.
Post-Marketing Safety Concerns With Palbociclib A Disproportionality Analysis of the FDA Adverse Event
Authors: Cheng Qian , Shi Xuan , Zhao Yazheng , Zou Shupeng , Sun Minghui 
Published: August 2023

Abstract

Purpose:By using U.S. Food and Drug Administration Adverse Event Reporting System (FAERS) database, the adverse reactions (ADRs) of palbociclib were mined through disproportionality analysis, so as to provide reference for rational use of palbociclib.Methods: Data mining of palbociclib-associated adverse events (AEs) was done by reporting odds ratio (ROR), proportional reporting odds ratio (PRR), Bayesian confidence propagation neural network (BCPNN), and multi-item gamma Poisson shrinkage (MGPS) algorithms.Findings: At the SOC level, the four algorithms simultaneously detected 18 positive signals, and at the PT level, the four algorithms simultaneously detected 65 positive signals. The PTs that lead to severe outcome are mainly associated with pulmonary toxicity, hematological toxicity and myelosuppression. Palbociclib-associated AEs had a median onset time of 79 days (interquartile range [IQR] 20-264 days), with the majority occurring within the first 1, 2, 3 months, and one year of treatment.Implications:The study identified potential palbociclib side effects and offered warnings for high-risk AEs, providing further data for palbociclib safety studies in breast cancer patients. Nonetheless, prospective clinical trials are needed to validate these results and explain their relationship.
Multi-period early-warning precipitation identification method at the easily-waterlogged districts in Jiangxi province, China
Authors: Bai Hua , Wang Bingxiang , Li Bin , Liu Zhangjun , Wen Zhenyu , Zhang Yang , Xiao Feng , Xu Xinfa , Huang Yongfeng 
Published: August 2023

Abstract
Urban easily-waterlogged districts need more systematic monitoring as the key disaster-forming and managing spatial scale, hard to identify the early-warning precipitation (EP). We proposed new algorithms to extract the urban easily-waterlogged hilly and plain districts’ polygons in Jiangxi Province, China. The districts’ disaster risk level prediction model was built through eleven intelligent algorithms’ optimization based on the field survey data. The muti-period EP values were identified using the scenario simulation by the model and further verified compared to the government-issued ones. It indicated that 532 easily-waterlogged districts possessed sufficient sample representativeness, represented by the significant coefficient of variation ≥ 0.66 for slope, waterlogging disaster area, and depth. The fine Gaussian support vector machine and fine K-Nearest Neighbor algorithms performed higher prediction accuracies of more than 86% and 83% in the model construction and verification districts, respectively. The 1-, 3-, and 6-hour severe waterlogging disaster’s EP medians were averaged to be 16.5-20.8, 31.5-35.8, and 35-39.3 mm differed among the optimum algorithms respectively, smaller than the government-issued ones. In comparison, the 1-, 3-, and 6-hour moderate waterlogging disaster’s EP medians were averaged to be 10.5-16.1, 25.5-31.1, and 29-34.6 mm respectively, larger than the issued ones.
Influence of anesthesia on lipidomic biomarkers in elderly patients undergoing hip replacement surgery
Authors: Li Lu , Zhang Wei , Li Chenxi , Zhang Hui , Zhang Jiaqiang 
Published: August 2023

Abstract

Purpose:
The purpose of this study was to examine the effect of anesthesia on biomarkers of lipidomics in elderly patients with hip replacements.
Methods:
Elective hip replacement patients were randomly divided into general anesthesia group (group G) or spinal anesthesia group (group P). In group G, anesthesia was induced intravenously, ventilation was maintained with a laryngeal mask, and anesthesia was maintained with a combination of intravenous and inhaled agents. In group P, a single subarachnoid block with ropivacaine was administered. Venous blood samples(5 ml each) for analysis were collected from all patients before anesthesia, from group G after they fully awoke following surgery, from group P approximately 1 h after surgery.
Results:
In this study, a total of 42 plasma samples (24 from group G and 18 from group P) were analyzed by lipid spectrometry.
A total of 1190 chemical species of lipids were detected, including 619 species of phospholipids, 512 species of glycerol lipids (GLs), 15 species of sphingolipids (SLs), 20 species of free fatty acids (FFAs), and 24 species of sterol lipids (STs).
Compared with group P, group G showed increased levels of phosphatidylethanolamine (PE), phosphatidylserine (PS), and triacylglycerol (TAG) and decreased levels of phosphatidylinositol (PI).
Conclusion:
The plasma lipidomic features of elderly hip arthroplasty patients were changed by anesthesia; these changes included increases in phosphatidylethanolamine (PE), phosphatidylserine (PS), and triacylglycerol (TAG) and a decrease in phosphatidylinositol (PI) in group G compared to group P. The mechanism and pathophysiological correlates of these changes need further clinical study.
Genetic Diversity and Structure of Chinese Chum Salmon (Oncorhynchus keta) Between Wild and Hatchery Populations Based on SSR Markers
Authors: Han Ye , Li Lin , Ge Zheng , Li Xiuying , Liu Huiji , Chen Weiqiang , Liu Peng , Fan Lihe , Li Guanying 
Published: August 2023

Abstract
The study was aimed at analyzing the genetic diversity and genetic structure of released populations and wild populations of chum salmon (Oncorhynchus keta) in the Tumen River Basin, and evaluating the effects of stock enhancement on the genetic diversity of wild populations. From 2014 to 2019, a total of 682 DNA samples from six wild populations and two hatchery populations were genotyped by using 10 pairs of self-developed microsatellite markers of chum salmon. Genetic diversity parameters and population structure were calculated by Cervus3.0, Structure2.3.4, Arlequin 3.5.2.2, GraphPad Prism and GenALEx 6.502. The results showed that the polymorphic information content (PIC) of 10 microsatellite loci ranged from 0.787–0.932, showing highly polymorphism. The average number of different alleles (NA) was 11.138 ± 0.999, the observed heterozygosity (Ho) and expected heterozygosity (HE) were 0.680 ± 0.058 and 0.784 ± 0.034, respectively. Shannon diversity index (I) was 1.872 ± 0.119. The inbreeding coefficient number (FIS) was 0.129 ± 0.054, indicating a certain degree of inbreeding. The population of chum salmon was divided into three groups by Bayesian genetic structure analysis and principal coordinate analysis, and there was significant genetic differentiation among the groups. AMOVA analysis revealed that most of the genetic variation came from within the population 87.77%, and 12.23% of the genetic variation came from between the populations. At present, the stock enhancement of chum salmon has no obvious effect on the genetic structure of wild population. Consequently, this study provides a scientific stock enhancement strategy as well as living resources database construction of O.keta.
Quinoline-based α-glucosidase inhibitors: synthesis, in vitro potency of inhibition, enzyme kinetics and in silico studies
Authors: Ghomi Minoo Khalili , Dastyafteh Navid , Montazer Mohammad Nazari , Noori Milad , Mojtabavi Somayeh , Faramarzi Mohammad Ali , Hashemi Seyedeh Mahdieh , Mahdavi Mohammad 
Published: August 2023

Abstract
In an attempt to find potential α-glucosidase inhibitors, a series of twenty new quinoline linked benzothiazole hybrids (8a-t) were synthesized in good yields from suitable reaction procedures and their chemical structures were analyzed by 1HNMR, 13CNMR, IR, and ESI-MS analysis. The synthesized derivatives further screened for their activity against α-glucosidase. Among them, compounds 8b, 8h, 8n and 8o exhibited remarkable α-glucosidase inhibitory activity with IC50 values ranging from 38.2 ± 0.3 to 79.9 ± 1.2 µM compared with standard drug acarbose (IC50 = 750.0 ± 2.0 µM). Enzyme kinetic studies of the most active compound (8h) indicated a non-competitive inhibition with Ki value of 38.2 µM. Moreover, the homology modeling, molecular docking and molecular dynamics simulation studies were conducted to reveal key interactions between the most active compound 8h and the targeted enzyme. These results are complementary to the experimental observations. In order to predict the druggability of the novel derivatives, the pharmacokinetic properties were also applied. These findings could be useful for the design and development of new α-glucosidase inhibitors.
McAPRR2 : The Key Regulator of Domesticated Pericarp Color in Bitter Gourd
Authors: Tian Shouwei , Yang Jingjing , Zhang Xiaofei , Fu Yiqian , Zhang Jian , Zhao Hong , Xia Changxuan , Zhou Mengyang , Liu Pangyuan , He Weiming , wen changlong 
Published: August 2023

Abstract
Pericarp color is a crucial commercial trait influencing consumer preferences for bitter gourds. However, until now, the gene responsible for this trait has remained unidentified. In this study, we identified a gene (McAPRR2) controlling pericarp color through a genome-wide association study (GWAS) utilizing the resequencing data of 106 bitter gourd accessions. McAPRR2 exhibits three primary haplotypes: Hap1 is wild type with green pericarp, Hap2 is SA and SEA type with green pericarp, and Hap3 is primarily SEA type with light green pericarp. McAPRR2 haplotype is significantly correlated with both pericarp color and ecological type. Importantly, McAPRR2 with the light green pericarp demonstrated a premature termination due to a 15 bp sequence insertion. The phylogenetic tree clustered according to pericarp color and ecological type, using SNPs located in the McAPRR2 gene and its promoter. High πwild/SEA and πSA/SEA values indicate high nucleotide diversity between wild and SEA types and between SA and SEA types in the McAPRR2 gene. The haplotypes, phylogenetic tree, and nucleotide diversity of McAPRR2 suggest that McAPRR2 has undergone domestication selection. This study identifies McAPRR2 as the key gene determining pericarp color in bitter gourds and introduces a novel insight that McAPRR2 is subject to domestication selection.
Palmitic acid activates GPRs/KLF7/HEY1 signal axis to promote the occurrence and development of endometrial carcinoma
Authors: Yang Bingqi , Yao Chen , Liu Jie , Hou Yanting , Liang Maodi , Chu Xiaolong , Tang Yihan , Wen Xin , Yuan Fangyuan , Peng Chaoling , Wang Cuizhe , Wang Jingzhou , Zhang Jun 
Published: August 2023

Abstract
Background:
Our previous study found that the increase of palmitic acid (PA) in serum after obesity is closely related to the development of endometrial cancer (EC), and the high concentration of PA can promote the biological behavior of EC cells by up-regulating the expression of KLF7, but the specific molecular mechanism are unclear.
Methods:
EC cells Ishikawa were treated with high concentrations(20μM and 50μM) of PA, the effects on the proliferative ability of Ishikawa cells were examined by CCK-8 and colony formation assay, and on the invasive and migratory ability of Ishikawa cells by transwell and scratch assay. RNA-Seq combined with double luciferase reporter gene experiment were used to confirm the key downstream target gene for KLF7. Constructing the model of obese mice with EC tumor, and collecting the endometrial tissues of EC patients and non-cancer individuals,we validated a possible molecular mechanism by which PA upregulation of KLF7 promotes EC development in vivo. The mRNA and protein expression levels of GPR40/120, KLF7 and HEY1 were detected in EC cells and tumor tissues by qRT-PCR and western-blot.
Results:
High concentrations of PA can up-regulate the expression of KLF7 through GPR40/120 and promote the biological behavior of EC cells. HEY1 may be a key downstream gene for KLF7 to promote the progression of EC. Under the state of obesity, the tumorigenesis ability of EC cells in mice was enhanced, and the expression of GPR40/120, KLF7 and HEY1 in tumor tissue increased. Up/down regulation of KLF7 can significantly enhance/weaken the tumorigenic ability of EC cells and promote/inhibit the expression of HEY1 in tumor tissues. The expression level of KLF7 and HEY1 in tumor tissues of EC individuals were significantly higher than that of non-cancer individuals.
Conclusions:
Increased PA content after obesity promotes the development of EC by activating the GPRs/KLF7/HEY1 signaling axis.
Pseudomonas beijingensis sp. nov., a novel species widely colonizing plant rhizosphere
Authors: Wu Jingyi , Liao Kaiji , Gu Yi-Lin , Wang Can , Li Jun-Zhou , Wei Hai-Lei 
Published: August 2023

Abstract
Three bacterial strains, FP830T, FP2034, and FP2262, were isolated from the rhizosphere soil of rice, corn, and highland barley plants in Beijing, Heilongjiang, and Tibet, respectively, in PR China. These strains are gram-negative, aerobic, and rod-shaped. They exhibited optimal growth at 28°C and pH 7.0 in the presence of 2% (w/v) NaCl and produced a diffusible fluorescent pigment under ultraviolet light when cultured on King's B plates. Phylogenetic analysis based on 16S rRNA gene and multilocus sequence data showed that FP830T, FP2034, and FP2262 belonged to the genus Pseudomonas and formed a distinct branch. The genome sizes of these three isolates ranged from 6.4 to 6.6 Mbp with a G+C content of 60.86-61.02 mol%. The orthologous average nucleotide identity and digital DNA-DNA hybridization values of strains FP830T, FP2034, and FP2262, along with their closest relatives, were not higher than 92.7% and 49.8%, respectively. These values were lower than the threshold range for prokaryotic species delineation. The dominant cellular fatty acids (> 10%) were C16:0, summed feature 3 (C16:1 ω7c and/or C16:1 ω6c), and summed feature 8 (C18:1 ω7c). The major polar lipids detected were phosphatidylethanolamine, diphosphatidylglycerol, and aminophospholipids. Additionally, the predominant respiratory quinone was ubiquinone (Q-9). Based on phenotypic, chemotaxonomic, and genotypic data, it was concluded that strains FP830T, FP2034, and FP2262 represented a novel species within the genus Pseudomonas. Therefore, the name Pseudomonas beijingensis sp. nov. was proposed for this novel species. The type strain was FP830T (=ACCC 62448T = JCM 35689T).
RouteMighty: Route Planning Software Engine For Abnormal Trucks Based On Graph Database Using Neo4j
Authors: Betkier Igor 
Published: August 2023

Abstract
This paper presents RouteMighty, a software application developed in Python for the efficient planning of routes for abnormal vehicles, such as those that are overweight or oversized. The software utilizes a dedicated graph structure implemented in Neo4j to optimize the route planning process. The application consists of numerous functions that validate the passability of infrastructure, such as bridges, tunnels, and narrow roads, ensuring that routes are safe and efficient. Additionally, RouteMighty is highly scalable, and it can easily be integrated with existing web mapping services, enabling users to access accurate, up-to-date information about road conditions and infrastructure. The software has been tested extensively, and the results show that it significantly improves the planning process for abnormal vehicles, reducing travel time and costs, while improving safety. Overall, RouteMighty represents a significant advancement in the field of route planning for abnormal vehicles, and it has the potential to revolutionize the way that such vehicles navigate complex road networks.
Hierarchical Structure for Semantic Segmentation of Roadway Images with Limited Visibility Using Deep Artificial Neural Networks
Authors: An Anthony , Mohan Manoah , Leppo Joshua , Haigh Emily , Tran Truong 
Published: August 2023

Abstract

The field of autonomous driving leaves minimal margins for error. Ensuring that self-driving vehicles possess the ability to accurately perceive their surroundings, even amidst conditions of limited visibility, is of utmost importance. We propose a novel approach to enhance the precision of object detection on the road during limited visibility driving or roadway conditions. The initial step involves the classification of the driving condition of an input image, and then, the corresponding semantic segmentation model will process the image to distinguish objects. Our dataset consists of roadway images depicting 20 distinct objects amidst adverse limited visibility conditions. The experimental results validate our approach, with the proposed method displaying quality accuracy levels for training, validation, and testing data. Our classification model achieved 100% accuracy. Particularly, the proposed methods achieved final mean IoU scores of 57.3%, 32.0%, 49.4%, and 47.8%, respectively, for FOG, NIGHT, RAIN, and SNOW conditions when using the U-NET model for segmentation. These mean IoU results are better than the traditional nonhierarchical training methods, which utilize the same U-NET structure.