bluuebunny/crossref_metadata_2025_split huggingface dataset:
Allogeneic stem cell transplant improves survival after first- or second-line therapy in TP53-mutated acute myeloid leukemia: Results from the Consortium on Myeloid Malignancies and Neoplastic Diseases (COMMAND).
Authors: Badar Talha , Atallah Ehab , Shallis Rory , Saliba Antoine , Patel Anand , Bewersdorf Jan , Grenet Justin , Stahl Maximilian , Duvall Adam , Burkart Madelyn , Palmisiano Neil , Bradshaw Danielle , Kubiak Michal , Dinner Shira , Goldberg Aaron , Abaza Yasmin , Murthy Guru Subramanian Guru , Kota Vamsi , Litzow Mark 
Published: December 2022

Abstract
We conducted a multi-center study to analyze factors predicting survival among patients with TP53-mutated (m) AML receiving allogeneic hematopoietic stem cell transplant (allo-HSCT) in the recent era. Among 370 patients, 68 (18%) patients were bridge to allo-HSCT. The median age of the patients was 63 years (range, 33–75), 82% of patients had complex cytogenetics and 66% of patients had multi-hit TP53m. Forty three percent received myeloablative conditioning (MAC) and 57% received reduced intensity conditioning (RIC). The incidence of acute graft versus host disease (GVHD) was 37% and chronic GVHD was 44%. The median event-free survival (EFS) from the time of allo-HSCT was 12.4 months (95% CI: 6.24–18.55) and median overall survival (OS) was 24.5 months (95% CI: 21.80-27.25). In multivariate analysis utilizing variables that showed significance in univariate analysis, complete remission at day 100 post allo-HSCT retained significance for EFS (HR: 0.24, 95% CI: 0.10–0.57, p = 0.001) and OS (HR: 0.22, 95% CI: 0.10–0.50, p = < 0.001). Similarly, occurrence of chronic GVHD retained significance for EFS (HR: 0.21, 95% CI: 0.09–0.46, p = < 0.001) and OS (HR: 0.34, 95% CI: 0.15–0.75, p = 0.007). Our report suggests that allo-HSCT offers the best opportunity to improve long-term outcome among patients with TP53m AML.
Identifying a promising inhibitor of Fusarium oxysporum f. sp. Lycopersici, Secreted in Xylem 1 protein
Authors: Rathore Anuranjan Singh , Gupta Krishna Kant , Jeyabharathy Chandrasekaran , Chandran Sam Aldrin 
Published: December 2022

Abstract
Fusarium oxysporum f. sp. Lycopersici (FOL) is a soil borne pathogen which infects tomato plants and inflicts severe damage, resulting in heavy yield losses throughout the world. FOL encodes several pathogenicity factors which are necessary for colonizing the host plant and establishing an infection successfully. Secreted in Xylem 1 (SIX1) was chosen for the present study since it is pivotal in determining host specificity and is also involved in pathogenicity/virulence. We predicted the structure of SIX1 by comparative modeling using Robetta server, as the structure of SIX1 is not elucidated. The best possible structure was refined, validated and used for subsequent analysis. In order to identify small molecules which can inhibit FOL, an antifungal library containing 16,824 compounds was screened using the predicted and validated structure. Five antifungal compounds were identified from the library. Ensuing analyses revealed that 4-[[2-(3-methoxyphenoxy) acetyl]amino] benzamide can interact with SIX1 in a stable manner. By inhibiting SIX1 we can inhibit FOL, hence 4-[[2-(3-methoxyphenoxy) acetyl]amino]benzamide is a promising candidate to prevent FOL infection. In addition to biocontrol methods and strategies using transgenic plants overexpressing resistance genes, the usage of small molecule inhibitors involving an integrated approach can be much more effective in combating FOL.
Magnetohydrodynamic Effect on Two-Phase Flow in the porous medium through a Rectangular Curved Duct
Authors: Rahman Md. Khalilur , Parvin Salma , Khan Md. Abdul Hakim 
Published: December 2022

Abstract
For the best structure and reliable maintenance, two- or multiphase flow is becoming more and more essential in engineering systems. However, a variety of different of biological organisms and natural phenomena that exhibit two-phase situations can be explored to improve our knowledge of this. This is so because current industrial technology does not place these limitations. This research aims to investigate the effect of an external magnetic field on unsteady laminar incompressible two-phase flow in a porous medium via a rectangular curved duct. The relevant governing equations are represented by the Navier-Stokes equations and by the Level set equation with boundary conditions. Fluid flow through curved rectangular ducts behaves differently from fluid flow through straight ducts due to the centrifugal action generated by duct curvature. Within curved ducts, centrifugal force is generated secondary flow vortices and spiraling fluid motion. This analysis graphically depicts the fluid phase distribution, the Dean vortex, velocity contours, and fluid volume fractions. Furthermore, displayed are the effects of the aspect ratio, porosity, Dean number, radius of curvature, and Hartmann number. Additionally, a comparison of two-phase flow between various fluids is presented.
Research and analysis of building-integrated photovoltaic (BIPV) products and systems for the China International Solar Decathlon Competition
Authors: Xu Weiyan , Xu Ning , Xia Heng , Tu Jielei 
Published: December 2022

Abstract
In order to study the energy-related behavior of BIPV, the building-integrated photovoltaic (BIPV) modules and systems of the International Solar Decathlon Competition were selected as an example. At different levels, from the three levels of "zero carbon emissions", "smart interconnection" and "healthy human settlements", discuss the carbon peak in 2030, the transformation of urban energy in the context of carbon neutrality in 2060, and BIPV based on macro scales of different needs The characteristics of adaptive spatial pattern of building integration. Then summarize the three aspects of active and passive energy saving, solar module and system heat gain, and prefabricated buildings, so as to provide researchers, architects, BIPV manufacturers and BIPV designers, active-passive technology in the future zero-energy solar residential design and practice It provides a certain technical reference for the integrated innovation and integrated application in this paper.
Properties of MDTM and RDTM for two–Dimensional Lane– Emden Equations and Systems Equations
Authors: Teyar Nadir 
Published: December 2022

Abstract
In this paper, I study the linear and the nonlinear forms of two–dimensional Lane–Emden type equations by proving and applying new product and quotient properties for different differential transform methods (RDTM and MDTM), in order to minimize computation to the maximum. I also introduce the two–dimensional Lane–Emden systems equations. I will obtain exact analytic solutions without linearization, discretization or perturbation, even with less computation.
Mathematics Subject Classification: 35J15, 35J47, 70F15, 35J75
Mapping the Clock Tower of the St Mark's square in Venice (Italy): stones, deterioration morphologies and their distribution
Authors: Piovesan Rebecca , Tesser Elena , Maritan Lara , Zaccariello Gloria , Mazzoli Claudio , Antonelli Fabrizio 
Published: December 2022

Abstract
In the frame of HYPERION EU project, aimed to develop a Decision Support System to improve resilience and sustainable reconstruction of historic areas against climate change and extreme events, Venice stands for its urban and architectonic complexity and richness.
In this system, the mapping of the ornamental stones and their deterioration morphologies of the Venice Clock Tower (Torre dell’Orologio) façade acts as a milestone on which building the knowledge-acquisition process on stone artefacts and their decay products. The Clock Tower is an early Renaissance building (1499) in Lombardesque stile standing over the entrance to the Mercerie on the northern side of the St. Mark square. Detailed surveys and mapping of both building materials (mainly stones) and deterioration morphologies were carried out, the latter following the weathering forms glossary, coupled an evaluation of their intensity. The data output consists of several monothematic maps, which can be separately handled, each one focusing on exact lithology or specific deterioration aspects. Moreover, a simple approach to graphically summarize the total state of deterioration of the building is here proposed in the form of a Total Deterioration Index (TDI) and its representation. The stones used in the façade are regional (Ammonitico Rosso and Scaglia Rossa) and extra-regional limestones (Istrian Stone), as well as Mediterranean white and coloured marbles and stones already used in antiquity (i.e. Fior di Pesco or marmor chalcidicum, Porfido rosso anticoor lapis porphyrites a volcanite from the Egyptian Eastern Desert, Proconnesian marble from the Microasiatic Marmara island, Pavonazzetto toscano and white Carrara marbles from Italian Apuan Alps). Their most frequent forms of deterioration detected are black crusts, patinas, discoloration and patterns linked to erosion processes. The interrelation of different mappings allowed some useful considerations about differences in the effectiveness of maintenance procedures between public and private management of the monument.
Existence and convergence of solutions for p-Laplacian systems with homogeneous nonlinearities on graphs *
Authors: Shao Mengqiu 
Published: December 2022

Abstract
In this paper, we investigate a class of p-Laplacian systems on a locally finite graph G = (V, E). By exploiting the method of Nehari manifold and some new analytical techniques, under suitable assumptions on the potentials and nonlinear terms, we prove that the p-Laplacian system admits a ground state solution (u λ , v λ) when the parameter λ is sufficiently large. Furthermore, we consider the concentration behavior of these solutions as λ → ∞, and show that these solutions converge to a solution of the corresponding limit problem.
MSC(2010): 35A15, 35Q55, 58E30
Some common fixed point theorems in bipolar metric spaces and applications
Authors: Paul Joginder , Chandra N. , Gairola U. C. 
Published: December 2022

Abstract
In this paper, we prove some common fixed point theorems for generalized rational type contraction in bipolar metric spaces. These theorems also generalize and extend several interesting results of metric fixed point theory to the bipolar metric context. In addition, there are some examples and applications for the obtained results.
2020 Mathematics Subject Classification. 47H10, 54H25.
Comparison of Femoral neck system and three cannulated cancellous screws in the treatment of vertical femoral neck fractures: clinical observation and finite element analysis
Authors: shaolong Huang , yazhong Zhang , xu Zhang , chengqiang Zhou , wenbo Li , yunqing Wang , bin Wang , ziqiang Zhu 
Published: December 2022

Abstract
Objective: The purpose of this study was to compare the biomechanical and clinical results of two surgical methods for the treatment of vertical femoral neck fractures: Femoral neck system (FNS) and traditional three-cannulated cancellous screws (CCS).
Methods: First, we developed three different vertical femoral neck fracture models for the finite element analysis, with angles of 55°, 65°, and 75°, respectively. Two experimental groups were set up: the FNS group and the CCS group. Each fracture group was tested under axial loads of 2100 N to measure the femur's displacement, Von Mise stress (VMS), and its internal fixation components. Secondly, we retrospectively included the cases of vertical femoral neck fractures with FNS and CCS in our hospital from May 2019 to May 2021. In this study, we compared the duration of intraoperative fluoroscopy, operative time, hospital stay, fracture healing time, Hemoglobin loss, Harris score of hip joint function, and postoperative complications among patients undergoing hip joint replacement.
Results: In terms of finite element analysis, FNS has better anti-displacement stability than CCS at 55°and 65°, while FNS is greater than CCS in Von Mise stress. Clinically, we followed up on 87 patients for an average of 12 months. FNS was superior to traditional CCS in fracture healing time, operation time, fluoroscopy duration, fracture healing time, and Harris hip function score.
Conclusion: FNS is superior to traditional CCS in biomechanical and clinical aspects of treating vertical femoral neck fractures. There is potential for FNS to become a new treatment option for vertical femoral neck fractures.
Alleviating Water Scarcity by Optimizing Crop Mixtures
Authors: Richter Brian , Ao Yufei , Lamsal Gambhir , Wei Dongyang , Marston Landon , Davis Kyle 
Published: December 2022

Abstract
Irrigated agriculture dominates freshwater consumption globally and has led to widespread drying of rivers and depletion of aquifers in regions where water demand exceeds naturally replenishment. In the US, this mismatch between irrigation demand and freshwater availability – combined with recurrent droughts and ongoing climate change – has meant that many farmers are experiencing water shortages. Yet there has been no spatially detailed assessment of where and to what extent the irrigation demands of specific crops contribute to water source depletion across the country. Here we combine modelled crop water requirements and detailed agricultural statistics within a national hydrological model to quantify sub-basin-level depletion, revealing high to severe levels of irrigation scarcity in 30% of sub-basins in the western US, with cattle-feed crops – alfalfa and other hay – being the largest water consumers in 57% of the region’s sub-basins. We also assessed recent trends in irrigation water consumption, crop production, and revenue generation in six high-profile farming areas and find that in recent decades, water consumption has decreased in four of our study areas – in large part due to due to shifts in the production of the most water-consumptive crops – even while farm revenues increased, suggesting the opportunity to decouple irrigation consumption from revenue generation. To examine opportunities for crop shifting to realize further reductions in water consumption, we then performed optimizations on feasible crop mixtures while holding farm revenues constant, finding that additional water savings of 21–59% are possible. These findings demonstrate strong opportunities for economic and environmental co-benefits in irrigated agriculture and provide both hope and direction to regions struggling with water scarcity around the world.
ALL ROAD USER CASUALTIES (KILLED) IN GREAT BRITAIN FROM 1926. LINEAR AND NONLINEAR TRENDS WITH PERSISTENT DATA
Authors: Gil-Alana Luis Alberiko 
Published: December 2022

Abstract
This paper deals with the analysis of road casualties in Great Britain, using annual data since 1926. Based on the persistent nature of the data, fractional integration methods are used that include linear and non-linear (structural breaks) models. The results indicate that when the whole data set is employed the series is nonstationary I(1) implying permanency of shocks. However, considering data starting in 1964 we observe a significant negative time trend along with a lower degree of integration that implies transitory shocks. In order to avoid the abrupt change produced by the break, a nonlinear deterministic trend model based on Chebyshev polynomials in time is also considered with the whole sample, and though the order of integration is much lower than 1, the unit root null hypothesis cannot yet be rejected.
JEL Classification: C22; C13; C54
Serial changes of the side-branch ostial area after single crossover stenting with kissing-balloon inflation
Authors: Fujimura Tatsuhiro , Okamura Takayuki , Nagoshi Ryoji , Murasato Yoshinobu , Yamawaki Masahiro , Miyazaki Yosuke , Akase Hideaki , Ono Shiro , Serikawa Takeshi , Hikichi Yutaka , Norita Hiroaki , Nakao Fumiaki , Sakamoto Tomohiro , Shinke Toshiro , Shite Junya 
Published: December 2022

Abstract
Purpose
We aimed to investigate the effect of the optimal rewiring position identified by three-dimensional optical coherence tomography (3D-OCT) on the side-branch ostium area (SBOA) after single crossover stenting with kissing-balloon inflation (single-stent KBI) for a bifurcation lesion at the follow-up in the left main coronary artery (LMCA) and in non-LMCA bifurcation.
Methods
Cases of bifurcation lesions with single-stent KBI that included OCT images post-procedure and at the 9-month follow-up were extracted from the 3D-OCT Bifurcation Registry, which is a multicenter-prospective registry of patients with a percutaneous coronary intervention for a bifurcation lesion under OCT guidance. The SBOA was measured by dedicated software, and the rewiring position at the side-branch ostium after crossover stenting was assessed by 3D-OCT. The optimal rewiring was defined as link-free-type and distal rewiring. The relationship between the optimal rewiring and the serial change of the SBOA was investigated separately in LMCA and non-LMCA cases.
Results
We examined 75 bifurcation lesions (LMCA, n = 35; non-LMCA, n = 40). The serial changes of the SBOA with the optimal rewiring were not significantly different regardless of LMCA and non-LMCA (LMCA:3.96 to 3.73 mm2, p = 0.38; non-LMCA:2.16 to 2.21 mm2, p = 0.98), whereas the serial changes of the SBOA with the sub-optimal rewiring were significantly reduced (LMCA:6.75 to 5.54 mm2, p = 0.013; non-LMCA:2.28 mm2 to 2.09 mm2, p = 0.024).
Conclusion
The side-branch ostial area dilated with the optimal rewiring position in a bifurcation lesion treated with single crossover stenting and kissing-balloon inflation was preserved regardless of whether the bifurcation was in the LMCA or a non-LMCA.
Numerical Simulation of parallel RLC Model Using Different Fractional Derivative Operators
Authors: Nazih Ahmed , Elminir Hamdy K. , Raslan W. E. , El-Kalla I. L. 
Published: December 2022

Abstract
The responses of a fractional RLC circuit based on Caputo, Caputo-Fabrizio, and Atangana-Baleanu derivatives were discussed in this paper. The results for the various orders are compared to each other. When the fractional order derivative tends to be one, the system's performance was found to be very slow due to a decrease in damping capacity.
Characterization of A Newfound Manganese Tungstate Mineral of Hübnerite in Turquoise Gemstone from Miduk Mine, Kerman, Iran
Authors: Rad Zahra Soleimani , Masoudi Fariborz , Tondkar Shirin 
Published: December 2022

Abstract
Turquoise is one of the most well-known gemstones in Iran. The mineralogy, crystallography, and gemology of Shahr-e-Babak turquoise in Kerman were investigated and the results are presented in this research. The Miduk porphyry copper deposit is positioned in the Shahr-Babak area in Kerman province, Iran. This deposit is located 85 km NW of the Sar-Cheshmeh porphyry copper deposit. Preliminary mineral exploration was carried out from 1967 to 1970. So far, more than 50 diamond drill holes with a maximum depth of 1013 m have proven the existence of the sizeable and potential porphyry copper mineralization in the Miduk deposit. The orebody contains 170 million tons of ore, with an average grade of 0.86% Cu, 0.007% Mo, 82 ppb Au and 1.8 ppm Ag. Supergene enrichment blankets average approximately 50 m in thickness and comprise the primary source of Cu ore. Petrography shows that the texture is homogeneous. In terms of a gemstone, greasy luster and blue color are seen, and samples are similar to what is commonly known as turquoise. The geometric minerals were detected in XRD analysis by analyzing the data using the x-part software. From the mineralogical point of view; the turquoise gemstones of Miduk of Kerman consist of turquoise, quartz, mica, and hübnerite. In this article, for the first time, we are stating the hübnerite mineral identified and seen in the Persian turquoise. Based on the obtained spectra, the main mineral of the Miduk samples from the six members of the turquoise family is the turquoise type with identical peaks that can be used as a reference for identification of the Miduk turquoise. This mineral is structurally composed of phosphate units, units of Al, Cu, water, and hydroxyl units, and does not include a Fe unit. In terms of gemology, the quality of a gemstone depends on the quantity of the turquoise phase and the amount of Cu in it according to SEM and XRD analysis.
Intramuscular compatibility of an injectable nanodispersion anti-inflammatory (Chronic®) from a standardized Bixa orellana oil: a toxicological study in Wistar rats
Authors: Carvalho Helison de Oliveira , Sauma Ana Laura Ribeiro , Nascimento Aline Lopes do , Teixeira Abrahão Victor Tavares de Lima , Gonçalves Danna Emanuelle Santos , Gomes Lauana , Furtado Gabriel da Costa , Silva Heitor Ribeiro da , de Souza Gisele Custódio , Salustiano Suéllen , Pereira Arlindo César Matias , Carvalho Jose Carlos Tavares 
Published: December 2022

Abstract
Bixa orellana L. is a plant popularly known as “ucurum”, “annatto”, and “achiote”. It is native to South America, and its seeds are an abundant source of geranylgeraniol and tocotrienols. Nanoencapsulation is a valuable technique that can decrease the drug needed to achieve an effect, decreasing potential toxicity and side effects. This study aimed to evaluate the acute toxicity of an intramuscular application of a nanodispersion containing a standardized extract (Chronic®) from the seeds of Bixa orellana (NBO) in Wistar rats. The chemical evaluation showed δ-tocotrienol at 0.725 ± 0.062 mg/ml (72.6 ± 0.9%). The stability study showed the nanoparticles had an average size from 53.15 ± 0.64 nm to 59.9 ± 3.63 nm, with a polydispersity index ranging from 0.574 ± 0.032 to 0.574 ± 0.32, Zeta potential from 18.26 ± 0.59 mV to 19.66 ± 1.45 mV. After testing the intramuscular application of NBO with doses from 1 to 5 mg/kg in animals, it was observed that the acute treatment did not elicit any toxic effects within this range. The dose of 10 mg/kg, although not affecting hematological and biochemical parameters (CPK, LDH, myoglobin, AST, ALT), could induce some muscle tissue changes, including leukocyte infiltration, morphological chances, and potentially necrosis. In conclusion, the results showed that the treatments devoided toxicity between 1 mg/kg and 5 mg/kg.
Increased Blood Flow Volume for Whole-body Thermal Therapy with a Hot Pack and Waon Therapy
Authors: Kominami Kazuyuki 
Published: December 2022

Abstract
Thermal therapy for chronic heart failure has been dominated by the use of Waon therapy (WT). We have previously examined the effects of whole-body thermal therapy using hot packs (HPTT), but the changes in blood flow volume with HPTT have not been verified. The purpose of this study was to compare lower extremity blood flow volume before and after HPTT and Waon therapy using venous occlusion plethysmography.
We recruited 11 healthy males (28.3±6.2 years). The participants underwent either HPTT and WT randomly over 24 hours. The HPTT protocol involved the patients being in a supine position on a bed for at least 10 minutes. Hot packs were then applied on the back, lower abdomen, and popliteal region for 15 minutes (warming). They were removed after 15 minutes, the participants continued bedrest for 30 minutes (heat-retention). WT was performed as previously reported. Blood flow volume was measured in the right lower leg by venous occlusion plethysmography before and after the thermal therapy.
Both thermal therapies significantly increased lower extremity blood flow volume (HPTT: 1.29±0.48⇒2.75±1.07%/min, p=0.001, WT: 1.51±0.85⇒2.83±0.90%/min, p<0.001). There was no significant difference between the pre- and post-implementation values of both thermal therapies, and no interaction effect was observed.
Conclusion: HPTT increased lower extremity blood flow volume approximately twice as much as at rest, and its effect was comparable to that of WT.