bluuebunny/crossref_metadata_2025_split huggingface dataset:
Paraventricular nucleus projections to the nucleus tractus solitarii are essential for full expression of hypoxia‐induced peripheral chemoreflex responses
Authors: Ruyle Brian C. , Lima‐Silveira Ludmila , Martinez Diana , Cummings Kevin J. , Heesch Cheryl M. , Kline David D. , Hasser Eileen M. 
Published: August 2023

AbstractThe hypothalamic paraventricular nucleus (PVN) is essential to peripheral chemoreflex neurocircuitry, but the specific efferent pathways utilized are not well defined. The PVN sends dense projections to the nucleus tractus solitarii (nTS), which exhibits neuronal activation following a hypoxic challenge. We hypothesized that nTS‐projecting PVN (PVN‐nTS) neurons contribute to hypoxia‐induced nTS neuronal activation and cardiorespiratory responses. To selectively target PVN‐nTS neurons, rats underwent bilateral nTS nanoinjection of retrogradely transported adeno‐associated virus (AAV) driving Cre recombinase expression. We then nanoinjected into PVN AAVs driving Cre‐dependent expression of Gq or Gi designer receptors exclusively activated by designer drugs (DREADDs) to test the degree that selective activation or inhibition, respectively, of the PVN‐nTS pathway affects the hypoxic ventilatory response (HVR) of conscious rats. We used immunohistochemistry for Fos and extracellular recordings to examine how DREADD activation influences PVN‐nTS neuronal activation by hypoxia. Pathway activation enhanced the HVR at moderate hypoxic intensities and increased PVN and nTS Fos immunoreactivity in normoxia and hypoxia. In contrast, PVN‐nTS inhibition reduced both the HVR and PVN and nTS neuronal activation following hypoxia. To further confirm selective pathway effects on central cardiorespiratory output, rats underwent hypoxia before and after bilateral nTS nanoinjections of C21 to activate or inhibit PVN‐nTS terminals. PVN terminal activation within the nTS enhanced tachycardic, sympathetic and phrenic (PhrNA) nerve activity responses to hypoxia whereas inhibition attenuated hypoxia‐induced increases in nTS neuronal action potential discharge and PhrNA. The results demonstrate the PVN‐nTS pathway enhances nTS neuronal activation and is necessary for full cardiorespiratory responses to hypoxia.
imageKey points
The hypothalamic paraventricular nucleus (PVN) contributes to peripheral chemoreflex cardiorespiratory responses, but specific PVN efferent pathways are not known.
The nucleus tractus solitarii (nTS) is the first integration site of the peripheral chemoreflex, and the nTS receives dense projections from the PVN.
Selective GqDREADD activation of the PVN‐nTS pathway was shown to enhance ventilatory responses to hypoxia and activation (Fos immunoreactivity (IR)) of nTS neurons in conscious rats, augmenting the sympathetic and phrenic nerve activity (SSNA and PhrNA) responses to hypoxia in anaesthetized rats.
Selective GiDREADD inhibition of PVN‐nTS neurons attenuates ventilatory responses, nTS neuronal Fos‐IR, action potential discharge and PhrNA responses to hypoxia.
These results demonstrate that a projection from the PVN to the nTS is critical for full chemoreflex responses to hypoxia.
The Element of Surprise: How Predictive Processing Can Help Coach Practitioners Understand and Develop Skilled Movement in Sport Settings
Authors: O’Brien Katherine A. , Kennedy Andrew , O’Keeffe Michael J. 
Published: August 2023

Predictive processing provides a framework for explaining how the brain solves problems of perception, decision making, and movement control by forming predictions, or plausible explanations, for what is happening in an approximately optimal manner. The strength or confidence of the prediction subjectively shapes whether something “surprising” has happened and whether a person’s perceptions and actions require adjustment. We put forward how predictive processing accounts of skill development emphasise predictive processes of action and perception that allows coaches who identify as “sporting ecology designers,” to better understand how to select the right action opportunities (i.e., affordances) to include in their training designs. We describe how motor learning can be incorporated into training designs through the element of “surprise” or the unexpected variations from the already established internal patterns that athletes have learned over time in a range of performance and practice settings. We conclude by presenting an applied example of coaching the backdoor cut manoeuver in basketball using predictive processing techniques, outlining how aspects of athlete knowledge, intentionality, memories, decision making, and prior experience cognitively coalesce during a coach-led training design to produce stable, yet flexible, movement couplings in a sport-based setting.
The Effect of a Physical Activity Intervention on Burden and Depressive Symptoms in Depressed Family Caregivers of Patients With Schizophrenia: A Randomized Controlled Trial
Authors: Bademli Kerime , Lök Neslihan , Lök Sefa 
Published: August 2023

Background: The study aimed to investigate the efficacy of a 12-week physical activity intervention for caregivers of patients with schizophrenia. Method: Family caregivers of patients with schizophrenia were recruited and randomized into either a physical activity group (n = 31) or a control group (n = 31). The 12-week “Physical Activity Program” consisted of 10 minutes of warm-up activities as the initial segment, 20 minutes of rhythmic exercises as the activity segment, 10 minutes of cool-down exercises as the final segment, and 40 minutes of free walking. The physical activity program was designed to accommodate the ergonomics and physiological structure of the caregiver. The program consisted of 12 sessions. The Zarit Caregiver Burden Scale and the Beck Depression Inventory were used to the physical activity and control groups before the program’s implementation. Results: A total of 62 caregivers were randomized to the intervention (n = 31) or control group (n = 31). Postintervention measurement was completed by 61 caregivers, and all the caregivers completed the intervention. Mean scores of Zarit Caregiver Burden Scale score and Beck Depression Inventory score in the physical activity group of caregivers at postintervention, significantly reduced at <.05 level than their mean baseline scores. Conclusions: Engagement in a 12-week physical activity intervention can improve the perceived burden of caregiving and symptoms of depression. Future research should examine with larger sample groups, carry out interventions, and apply the physical activity intervention by targeting caregivers, along with different interventions.
Dynamics of cosmological model with domain walls and massive scalar fields in f(R,T) gravity
Authors: Rao V. Sreenivasa , Ganesh V. , Dasunaidu K. 
Published: August 2023

A spatially homogenous and anisotropic locally rotationally symmetric (LRS) Bianchi type-I space-time is considered in the presence of a massive scalar field containing domain walls in the framework of the [Formula: see text] gravity proposed by Harko et al. [Phys. Rev. D 84, 024020, (2011)]. Solving the field equations of the model using a relation between metric potentials and power law between the scalar field and average scale factor of the model, an anisotropic cosmological model with massive scalar fields and domain walls in [Formula: see text] theory is presented. These conditions result in a model solution that provides a dynamic deceleration parameter. The model’s geometrical and physical properties are also examined. The universe exhibits a smooth transition from its early decelerated phase to its current accelerated phase, as shown by the study of the deceleration parameter. The statefinder plane corresponds to the Chaplygin gas era and the model finally approaches [Formula: see text]CDM model.
Improving Computation and Memory Efficiency for Real-world Transformer Inference on GPUs
Authors: Du Jiangsu , Jiang Jiazhi , Zheng Jiang , Zhang Hongbin , Huang Dan , Lu Yutong 
Published: August 2023

Transformer models have emerged as a leading approach in the field of natural language processing (NLP) and are increasingly being deployed in production environments. Graphic processing units (GPUs) have become a popular choice for the transformer deployment and often rely on the batch processing technique to ensure high hardware performance. Nonetheless, the current practice for transformer inference encounters computational and memory redundancy due to the heavy-tailed distribution of sequence lengths in NLP scenarios, resulting in low practical performance.
In this article, we propose a unified solution for improving both computation and memory efficiency of the real-world transformer inference on GPUs. The solution eliminates the redundant computation and memory footprint across a transformer model. At first, a GPU-oriented computation approach is proposed to process the self-attention module in a fine-grained manner, eliminating its redundant computation. Next, the multi-layer perceptron module continues to use the word-accumulation approach to eliminate its redundant computation. Then, to better unify the fine-grained approach and the word-accumulation approach, it organizes the data layout of the self-attention module in block granularity. Since aforementioned approaches make the required memory size largely reduce and constantly fluctuate, we propose the chunk-based approach to enable a better balance between memory footprint and allocation/free efficiency. Our experimental results show that our unified solution achieves a decrease of average latency by 28% on the entire transformer model, 63.8% on the self-attention module, and reduces memory footprint of intermediate results by 7.8×, compared with prevailing frameworks.
A Rare Case of Lipomatous Variant Mammary-Type Myofibroblastoma of the Lateral Tongue
Authors: Spalti Matthew , Samim Firoozeh , Florianova Livia 
Published: August 2023

Mammary-type myofibroblastoma (MTMF) is an unusual and rare benign tumor that typically presents in older men or post-menopausal females. A 53-year-old female presented with a 6-month history of an asymptomatic pink/white submucosal nodule involving the left lateral tongue. Clinical examination showed a

5

mm
×
5

mm
×
5

mm

firm submucosal nodule with intact overlying mucosa. Differential diagnoses focused on benign nodular connective tissue tumors. An excisional biopsy was performed and submitted for histopathological examination. The patient underwent conservative local excision. Histopathology and immunocytochemistry revealed a lipomatous variant of MTMF. Hematoxylin and eosin sections revealed an unencapsulated soft tissue lesion with a lobular growth pattern. The neoplasm was biphasic, comprising adipose tissue and cellular fibrous components. By immunohistochemistry, tumor cells were positive for desmin, estrogen receptor, and CD34. In summary, we presented an unusual case of a lipomatous variant of myofibroblastoma on the tongue. MTMF rarely occurs in the head and neck and its accurate diagnosis necessitates awareness of its histomorphological spectrum and application of appropriate immunohistochemical stains.
Angefleht und dann beopfert: Zur Beziehung von Mythos und Festritual in hethitischen Texten
Authors: Görke Susanne 
Published: August 2023

Abstract
This article considers the relationship of Hittite festival rituals and mythical accounts, based on the mythical narrative of the feast of the sun god, in which the invited deities are not satiated despite sufficient food and drink. It is shown that the myths of the disappearing and returning deities were originally invocations or supplications (mugawar) incorporated into ritual acts that were intended to summon a deity. From the Middle Hittite period onward, rituals for invoking deities (mukeššar) seem to have been distinguished from ritual offerings to deities, which could then be called festival rituals (EZEN₄). In the process, an occasion-bound invocation of a deity due owing to some emergency situation may have been reinterpreted as an invocation to guarantee the deity’s presence, which in the further course lost its significance for being written down while the ritual descriptions gained in importance. At the same time, the invocations may have been literarily processed and expanded, e.g., by southeast Anatolian descriptions of rites of evocation.
Comparison of amphibian diversity in areas under intensive versus subsistence agriculture in Uganda
Authors: Akoth Sisiria , Kityo Robert , Akite Perpetra , Behangana Mathias , Insingoma Joseph , Babyesiza Sadic Waswa , Sande Eric , Luiselli Luca 
Published: August 2023

Abstract
Agricultural intensification has increasingly destroyed natural habitats, resulting in species declines. Insights into the effects of landscape structure on species’ diversity and distribution are needed to effectively conserve biodiversity in agricultural landscapes. The influence of land use practices on amphibian species diversity was investigated in areas of intensive and subsistence agriculture in Namulonge (Uganda, East Africa) using visual encounter surveys while environmental parameters were also recorded. A total of 19 amphibian species were recorded. Species richness varied minimally between intensive and subsistence agriculture plots. However, there was a significant variation in species’ abundance between the two land use areas and the species diversity was reduced in the intensive-agriculture area. The relationship between habitat characteristics and species distribution was statistically significant: in areas with relatively intact natural vegetation cover more species occurred. Such pockets of vegetation provide microhabitat conditions suitable for foraging, breeding and cover. Therefore, the abovementioned observation suggests that there is value at the landscape level to preserve natural/seminatural pockets of vegetation to enhance biodiversity in any agricultural environment.
Age and growth of the mountain dragon, Diploderma micangshanense (Squamata: Lacertilia: Agamidae)
Authors: Liu Xiuying , Li Guanglu , Liu Changxiu , Xiong Jianli 
Published: August 2023

Abstract
Knowledge of life history is important for understanding population ecology. The genus Diploderma is one of the most diverse genera in the family Agamidae, and no data on the life history traits of Diploderma species have been reported to date. Here, the age and growth of a population of D. micangshanense were revealed using skeletochronology for the first time. Females have greater snout-vent length (SVL) than males, but the mean SVL did not significantly differ between the sexes. Age ranged from one to four years in both sexes, and mean ages were 2.24 ± 0.10 years for males and 2.28 ± 0.12 years for females. No significant sexual differences were detected in either age structure or mean age. Age and body size were significantly positively correlated in both sexes. The growth coefficient k (males: 0.510; females: 0.441) and growth rate (males: 4.33 ± 0.38; females: 4.91 ± 0.39) were similar in both sexes. These results have implications for the population dynamics and management of this species.
The (Im)perfect Automation Schema: Who Is Trusted More, Automated or Human Decision Support?
Authors: Rieger Tobias , Kugler Luisa , Manzey Dietrich , Roesler Eileen 
Published: August 2023

Objective This study’s purpose was to better understand the dynamics of trust attitude and behavior in human-agent interaction. Background Whereas past research provided evidence for a perfect automation schema, more recent research has provided contradictory evidence. Method To disentangle these conflicting findings, we conducted an online experiment using a simulated medical X-ray task. We manipulated the framing of support agents (i.e., artificial intelligence (AI) versus expert versus novice) between-subjects and failure experience (i.e., perfect support, imperfect support, back-to-perfect support) within subjects. Trust attitude and behavior as well as perceived reliability served as dependent variables. Results Trust attitude and perceived reliability were higher for the human expert than for the AI than for the human novice. Moreover, the results showed the typical pattern of trust formation, dissolution, and restoration for trust attitude and behavior as well as perceived reliability. Forgiveness after failure experience did not differ between agents. Conclusion The results strongly imply the existence of an imperfect automation schema. This illustrates the need to consider agent expertise for human-agent interaction. Application When replacing human experts with AI as support agents, the challenge of lower trust attitude towards the novel agent might arise.
Confronted With Death: Factors Affecting End of Life Decisions in the Intensive Care Unit
Authors: ul Hassan Syed Sabih , Ali Wajid , Khan Hamza , Raja Ahsan Raza , Hassan Murtuza , Haque Ghazal , Ayub Farwa , Waqar Muhammad Atif , Latif Asad 
Published: August 2023

To determine how often care is limited at the end of life and the factors that are associated with this decision, we reviewed the medical records of all patients that passed away in the intensive care units (ICU) of Aga Khan University. We found that a majority of patients had Do-Not-Resuscitate orders in place at the time of death. Our analysis yielded 6 variables that were associated with the decision to limit care. These are patient age, sex, duration of mechanical ventilation, Glasgow Coma Scale (GCS) ≤8 at any point during ICU stay, GCS ≤8 in the first 24 hours following ICU admission, and mean arterial pressure <65 mm of Hg while on vasopressors in the first 24 hours following ICU admission. These variables require further study and should be carefully considered during end of life discussions to allow for optimal management at the end of life.
Establishment of a national quality improvement process on oxygen delivery index during cardiopulmonary bypass
Authors: Stammers Alfred H , Chores Jeffrey B , Tesdahl Eric A , Patel Kirti P , Baeza Jennifer , Mosca Matthew S , Varsamis Michalis , Petterson Craig M , Firstenberg Michael S , Jacobs Jeffrey P 
Published: August 2023

Targeted oxygen delivery during cardiopulmonary bypass (CPB) has received significant attention due to its influence on patient outcomes, especially in mitigating acute kidney injury. While it has gained popularity in select institutions, there remains a gap in establishing it globally across multiple centers. The purpose of this investigation was to describe the development of a quality improvement process of targeted oxygen delivery during CPB across hospitals throughout the United States. A systematic approach to utilize oxygen delivery index (DO2i) as a key performance indicator within hospitals serviced by a national provider of perfusion services. The process included a review of the current literature on DO2i, which yielded a target nadir value (272 mL/min/m2) and an area under the curve (DO2i272AUC) cut off of 632. All data is displayed on a dashboard with results categorized across multiple levels from system-wide to individual clinician performance. From January 2020 through December 2022, DO2i data from 91 hospitals and 11,165 coronary artery bypass graft procedures were collected. During this period the monthly proportion of DO2i measurements above the target nadir DO2i272 ranged from 60.5% to 78.4% with a mean+/−SD of 70.8 +/- 4.2%. Binary logistic regression for the first 7 months following monthly DO2i performance reporting has shown a statistically significant positive linear trend in the probability of achieving the target DO2i272 ( p < .001), with a crude increase of approximately 7.8% for DO2i272AUC, and a 73.8% success rate ( p < .001). A survey was sent to all individuals measuring oxygen delivery during CPB to assess why a target DO2i272 could not be reached. The two most common responses were an ‘inability to improve CPB flow rates’ and ‘restrictive allogeneic red blood cell transfusion policies’. This study demonstrates that targeting a minimum level of oxygen delivery can serve as a key performance indicator during CPB using a structured quality improvement process.
Exploring attitudes of people with chronic health conditions towards the use of group-based telerehabilitation: A qualitative study
Authors: Barry Walsh Caoimhe , Cahalan Roisin , Hinman Rana S , O’Sullivan Kieran 
Published: August 2023

Objective The study explores the attitudes of people with chronic health conditions towards the use of group-based telerehabilitation. Design A qualitative research study. Setting The setting involved semi-structured focus groups via videoconferencing software. Participants A purposive sample of 18 people with chronic health conditions including cardiorespiratory, neurological and musculoskeletal conditions was recruited via national patient advocacy and support groups in Ireland and clinical contacts. The sample included both those who had, and had not, previously engaged in telerehabilitation programmes. Procedures An online questionnaire collected demographic information and data regarding previous telerehabilitation participation and telerehabilitation preferences. Focus groups were conducted using videoconferencing software, in accordance with the Consolidated Criteria for Reporting Qualitative Research (COREQ) Checklist, and analysed using thematic analysis following Braun and Clarke's methodology. Findings were triangulated with quantitative questionnaire data. Results Four focus groups were conducted including participants with chronic cardiorespiratory ( n = 8), neurological ( n = 6) and musculoskeletal ( n = 4) conditions. Three themes were identified regarding telerehabilitation: (a) benefits and facilitators (including convenience, increased service accessibility, social connection and technological support), (b) challenges and barriers (including technological access and literacy, limited ‘hands-on’ therapy, safety concerns and social limitations), and (c) preferences (regarding mode of delivery, content, duration and generic programmes for mixed-condition groups). Conclusions Telerehabilitation is convenient for people with chronic conditions; however, concerns exist regarding the use of technology and the limitations of this healthcare delivery method. The role of telerehabilitation is valued, and future programmes should acknowledge patient preferences including a hybrid model of care, exercise and educational content, social interaction and synchronous components.
Differences of chronological seasonality in drug overdose
Authors: Lo Chih-Hung , Liao Chen-Hao , Tan Sheng-Teck , Su Yu-Jang 
Published: August 2023

Objective To investigate the association between seasonality and intentional drug overdose (IDO), a commonly seen method of self-harm in daily emergency medicine practice. Methods Cases of IDO were retrospectively selected using the International Classification of Diseases (ICD)-10 coding system (codes T36–T50), in patients who attended the Emergency Department of MacKay Memorial Hospital between January 2018 and August 2019. Data regarding age, sex, arrival time, marital status, vital signs, comorbidities, psychiatric history, social conflicts, substance of overdose, and length of hospital stay by season, were analysed using Student’s t-test and χ2-test. Results Of all included cases ( n = 196), IDO occurred most frequently in spring (32.1%), particularly in male patients (28/49 male cases). First-time IDO occurred most frequently in spring (51/133 first-time cases) and most spring cases were first-time IDO (51/63 spring cases). Repeat IDO occurred most frequently in autumn (20/63 repeat cases). Female conflict with father and/or boyfriend, and personality disorder in patients who overdosed, showed seasonality with a spring peak. Hospital admission rate was highest in winter (10/45 winter cases [22.2%]). Conclusion Episodes of IDO exhibited seasonality, with a spring peak, particularly for male patients, female patients in conflict with father and/or boyfriend, and those with personality disorder. Clinicians should pay close attention to the abovementioned patient groups.