bluuebunny/crossref_metadata_2025_split huggingface dataset:
Updates on polyurethane and its multifunctional applications in biomedical engineering
Authors: Miri Zahra , Farè Silvia , Ma Qianli , Haugen Håvard J 
Published: August 2023

Abstract
Polyurethanes (PUs) have properties that make them promising in biomedical applications. PU is recognized as one of the main families of blood and biocompatible materials. PU plays a vital role in the design of medical devices in various medical fields. The structure of PU contains two segments: soft and hard. Its elastomeric feature is due to its soft segment, and its excellent and high mechanical property is because of its hard segment. It is possible to achieve specific desirable and targeted properties by changing the soft and hard chemical structures and the ratio between them. The many properties of PU each draw the attention of different medical fields. This work reviews PU highlighted properties, such as biodegradability, biostability, shape memory, and improved antibacterial activity. Also, because PU has a variety of applications, this review restricts its focus to PU’s prominent applications in tissue engineering, cardiovascular medicine, drug delivery, and wound healing. In addition, it contains a brief review of PU’s applications in biosensors and oral administration.
From data to insight, enhancing structural health monitoring using physics-informed machine learning and advanced data collection methods
Authors: Rizvi Syed Haider M , Abbas Muntazir 
Published: August 2023

Abstract
Owing to recent advancements in sensor technology, data mining, Machine Learning (ML) and cloud computation, Structural Health Monitoring (SHM) based on a data-driven approach has gained more popularity and interest. The data-driven methodology has proved to be more efficient and robust compared with traditional physics-based methods. The past decade has witnessed remarkable progress in ML, especially in the field of Deep Learning (DL) which are effective in many tasks and has achieved state-of-the-art results in various engineering domains. In the same manner, DL has also revolutionized SHM technology by improving the effectiveness and efficiency of models, as well as enhancing safety and reliability. To some extent, it has also paved the way for implementing SHM in real-world complex civil and mechanical infrastructures. However, despite all the success, DL has intrinsic limitations such as its massive-labelled data Requirement, inability to generate consistent results and lack of generalizability to out-of-sample scenarios. Conversely, in SHM, the lack of data corresponding to a different state of the structure is still a challenging task. Recent development in physics-informed ML methods has provided an opportunity to resolve these challenges in which limited-noisy data and mathematical models are integrated through ML algorithms. This method automatically satisfies physical invariants providing better accuracy and improved generalization. This manuscript presents the sate-of-the-art review of prevailing ML methods for efficient damage inspection, discuss their limitations, and explains the diverse applications and benefits of physics-informed ML in the SHM setting. Moreover, the latest data extraction strategy and the internet of things (IoT) that support the present data-driven methods and SHM are also briefly discussed in the last section.
Research progress on the design of electrolyte additives and their functions for zinc-ion batteries
Authors: Cui Yuxin , Zhang Ruixin , Yang Sinian , Liu Lili , Chen Shimou 
Published: August 2023

Abstract
In recent years, zinc-ion batteries (ZIBs) have been considered one of the most promising candidates for next-generation electrochemical energy storage systems due to their advantages of high safety, high specific capacity and high economic efficiency. As an indispensable component, the electrolyte has the function of connecting the cathode and the anode, and plays a key role in the performance of the battery. Different types of electrolytes have different effects on the performance of ZIBs, and the use of additives has further developed the research on modified electrolytes, thus effectively solving many serious problems faced by ZIBs. Therefore, to further explore the improvement of ZIBs by electrolyte engineering, it is necessary to summarize the current status of the design of various electrolyte additives, as well as their functions and mechanism in ZIBs. This paper analyzes the challenges faced by different electrolytes, reviews the different solutions of additives to solve battery problems in liquid electrolytes and solid electrolytes, and finally makes suggestions for the development of modified ZIB electrolytes. It is hoped that the review and strategies proposed in this paper will facilitate development of new electrolyte additives for ZIBs.
The Myth of Transnational Public Policy in International Arbitration
Authors: Kleinheisterkamp Jan 
Published: August 2023

Abstract
This Article traces the concept of transnational public policy as developed in the context of international arbitration at the intersection between legal theory and practice. The emergence of such a transnational public policy, it is claimed, would enable arbitrators to safeguard and ultimately to define the public interests that need to be protected in a globalized economy, irrespective of national laws. A historical contextualization of efforts to empower merchants and their practices in Germany and the United States in the nineteenth and early twentieth centuries highlights their reliance on the mythical lex mercatoria that shaped English commercial law. Further contextualization is offered by the postwar invocation of “general principles of law recognized by civilized nations,” to keep at bay the application of supposedly less civilized, parochial legal orders, and by the consequent emergence of the “new” lex mercatoria as conceptualized especially in France. These developments paved the way, on the theory side, for later conceptualizations of self-constitutionalizing law beyond the state, especially by Gunther Teubner, and, on the practice side, for the notion of transnational public policy developed by arbitrators, especially by Emmanuel Gaillard, culminating in jurisprudential claims of an autonomous arbitral legal order with a regulatory dimension. In all these constructions, the recourse to comparative law has been a crucial element. Against this rough intellectual history, the Article offers a critique of today’s construction of transnational public policy by probing into its constitutional dimension and the respective roles of private and public interests. This allows, in particular, to draw on parallels to historic U.S. constitutional debates on the allocation of regulatory powers in federalism.
An Executive Functioning Composite Does Not Moderate the Relationship Between Combat Exposure and Posttraumatic Stress Disorder Symptom Clusters
Authors: Etzel Lena , Miskey Holly M , Webb Jennifer B , Demakis George J , Harris Henry L , Shura Robert D 
Published: August 2023

Abstract

Objective
Posttraumatic stress disorder (PTSD) is prevalent among U.S. combat Veterans, and associated with poor health and wellbeing. As combat experiences are likely to significantly modify self-, other-, and society-oriented cognitions and heighten risk for PTSD, examination of related cognitive processes may yield new treatment strategies. The cognitive model of PTSD suggests that persistent threat perceptions contribute to symptom worsening. Thus, cognitive processes of shifting perspectives or generating novel interpretations may be particularly relevant to lessen PTSD symptoms. This cross-sectional study examined executive functioning as a moderator to the relationship between combat exposure and PTSD symptom clusters among post-9/11 Veterans.

Method
Data from 168 Veterans were drawn from a larger study examining post-deployment mental health and cognitive function. An executive functioning composite derived from Wisconsin Card Sorting Test Perseveration Errors, WAIS-III Similarities, Trail Making Test B, and Stroop Color-Word Inhibition scores was computed. Path analysis was used to test the moderation model.

Results
After accounting for age, sex, and estimated premorbid functioning, results indicated that combat exposure was associated with all symptom clusters on the PTSD Checklist–Military. Executive functioning was not significantly associated with the PTSD symptom clusters and did not moderate the relationship between combat exposure and any of the PTSD symptom clusters.

Conclusions
Combat exposure is an important dimension of risk related to PTSD in Veterans that warrants regular screening. Moderation by executive functioning was not observed despite theoretical support. Future work could test methodological and sampling reasons for this finding to determine if theoretical adjustment is necessary.
French adult normative data for a Standard Executive Neuropsychological Test Battery
Authors: Bayard Sophie , Madiouni Clarisse , Niel Carlos Cécile , Cornu Charlotte , Moulin Aurélie , Raffard Stéphane 
Published: August 2023

Abstract

Objective
Executive impairments are frequent and may concern a large spectrum of health conditions throughout life. Given the complexity of the executive functions, their assessment requires the administration of multiple tests. There is only one source of French-language normative data for seven traditional executive tests for adults under age 50. The aim of the present study was to establish demographically adjusted normative data of four executive tests commonly used during the neuropsychological assessment in France for adults aged 18–65.

Method
The following tools were administered to 518 community adults aged from 18 to 65: Digit Span, Trail Making Test, Color Word Interference Test, and Verbal Fluency Test. An Overall Test Battery Mean was computed. Multiple regressions were computed for normally distributed scores and percentiles were established for non-normally distributed scores.

Results
Multiple regression analyses indicated that younger age and higher education were both associated with better performance. Age did not predict the number of correct responses on the Verbal Fluency Test. Gender did not have any effect on executive performances. Regression equations to calculate Z-scores are presented. Percentiles are presented for the number of recorded errors on the Trail Making Test, Color Word Interference Test, and Verbal Fluency Test.

Conclusions
We provide reliable and updated norms for four executive tests that are among the most used by clinical neuropsychologists in France. Our work represents a valuable addition to the limited norms currently available for the assessment of executive functions in French young and middle-aged adults.
Multilocus-sequence typing reveals clonality of Staphylococcus aureus in atopic dermatitis
Authors: Blicharz Leszek , Szymanek-Majchrzak Ksenia , Młynarczyk Grażyna , Czuwara Joanna , Waśkiel-Burnat Anna , Goldust Mohamad , Samochocki Zbigniew , Rudnicka Lidia 
Published: August 2023

Abstract

Background
Atopic dermatitis (AD) is exacerbated by Staphylococcus aureus, which is capable of displacing not only the physiological microbiota, but also other strains of its own species. Analyses of the molecular characteristics and relationships of S. aureus strains present in different microniches are lacking.

Objectives
To determine, using multilocus sequence typing (MLST), the relationship of S. aureus isolates from the lesional and nonlesional skin and anterior nares of patients with AD, and to review the characteristics of the dominant clones.

Methods
Sixty-three individuals with active AD were enrolled. Ten patients with moderate-to-severe AD (SCoring of Atopic Dermatitis score ≥ 25) colonized by S. aureus in all analysed locations were included in the MLST analysis.

Results
The most prevalent sequence types were 7 (10/30 strains; 33.3%), 15 and 97 (both 5/30 strains; 16.7%) all of which were associated with the expression of adhesins and toxins promoting chronic microbial dysbiosis, skin barrier damage and inflammation. Six patients (60%) were carriers of clonal S. aureus strains at all analysed locations, three (30%) carriers in lesional and nonlesional skin, and one (10%) was a carrier in nonlesional skin and the anterior nares.

Conclusions
The results imply that the identified S. aureus lineages are better adapted to dominate the microbiota in AD. Decontaminating the identified reservoirs of S. aureus (i.e. anterior nares and nonlesional skin) could reduce the severity of AD.
Soluble wild-type ACE2 molecules inhibit newer SARS-CoV-2 variants and are a potential antiviral strategy to mitigate disease severity in COVID-19
Authors: Ameratunga Rohan , Mears Emily , Leung Euphemia , Snell Russell , Woon See-Tarn , Kelton William , Medlicott Natalie , Jordan Anthony , Abbott William , Steele Richard , Rolleston William , Longhurst Hilary , Lehnert Klaus 
Published: August 2023

Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for coronavirus disease of 2019 (COVID-19), has caused havoc around the world. While several COVID-19 vaccines and drugs have been authorized for use, these antiviral drugs remain beyond the reach of most low- and middle-income countries. Rapid viral evolution is reducing the efficacy of vaccines and monoclonal antibodies and contributing to the deaths of some fully vaccinated persons. Others with normal immunity may have chosen not to be vaccinated and remain at risk if they contract the infection. Vaccines may not protect some immunodeficient patients from SARS-CoV-2, who are also at increased risk of chronic COVID-19 infection, a dangerous stalemate between the virus and a suboptimal immune response. Intra-host viral evolution could rapidly lead to the selection and dominance of vaccine and monoclonal antibody-resistant clades of SARS-CoV-2.
There is thus an urgent need to develop new treatments for COVID-19. The NZACE2-Pātari project, comprising modified soluble angiotensin-converting enzyme 2 (ACE2) molecules, seeks to intercept and block SARS-CoV-2 infection of the respiratory mucosa. In vitro data presented here show that soluble wild-type ACE2 molecules retain the ability to effectively block the Spike (S) glycoprotein of SARS-CoV-2 variants including the ancestral Wuhan, delta (B.1.617.2) and omicron (B.1.1.529) strains. This therapeutic strategy may prove effective if implemented early during the nasal phase of the infection and may act synergistically with other antiviral drugs such as Paxlovid to further mitigate disease severity.
Prefrontal GABA and glutamate–glutamine levels affect sustained attention
Authors: Kondo Hirohito M , Terashima Hiroki , Kihara Ken , Kochiyama Takanori , Shimada Yasuhiro , Kawahara Jun I 
Published: August 2023

Abstract
Attention levels fluctuate during the course of daily activities. However, factors underlying sustained attention are still unknown. We investigated mechanisms of sustained attention using psychological, neuroimaging, and neurochemical approaches. Participants were scanned with functional magnetic resonance imaging (fMRI) while performing gradual-onset, continuous performance tasks (gradCPTs). In gradCPTs, narrations or visual scenes gradually changed from one to the next. Participants pressed a button for frequent Go trials as quickly as possible and withheld responses to infrequent No-go trials. Performance was better for the visual gradCPT than for the auditory gradCPT, but the 2 were correlated. The dorsal attention network was activated during intermittent responses, regardless of sensory modality. Reaction-time variability of gradCPTs was correlated with signal changes (SCs) in the left fronto-parietal regions. We also used magnetic resonance spectroscopy (MRS) to measure levels of glutamate–glutamine (Glx) and γ-aminobutyric acid (GABA) in the left prefrontal cortex (PFC). Glx levels were associated with performance under undemanding situations, whereas GABA levels were related to performance under demanding situations. Combined fMRI–MRS results demonstrated that SCs of the left PFC were positively correlated with neurometabolite levels. These findings suggest that a neural balance between excitation and inhibition is involved in attentional fluctuations and brain dynamics.
Age differentially modulates the cortical tracking of the lower and higher level linguistic structures during speech comprehension
Authors: Xu Na , Qin Xiaoxiao , Zhou Ziqi , Shan Wei , Ren Jiechuan , Yang Chunqing , Lu Lingxi , Wang Qun 
Published: August 2023

Abstract
Speech comprehension requires listeners to rapidly parse continuous speech into hierarchically-organized linguistic structures (i.e. syllable, word, phrase, and sentence) and entrain the neural activities to the rhythm of different linguistic levels. Aging is accompanied by changes in speech processing, but it remains unclear how aging affects different levels of linguistic representation. Here, we recorded magnetoencephalography signals in older and younger groups when subjects actively and passively listened to the continuous speech in which hierarchical linguistic structures of word, phrase, and sentence were tagged at 4, 2, and 1 Hz, respectively. A newly-developed parameterization algorithm was applied to separate the periodically linguistic tracking from the aperiodic component. We found enhanced lower-level (word-level) tracking, reduced higher-level (phrasal- and sentential-level) tracking, and reduced aperiodic offset in older compared with younger adults. Furthermore, we observed the attentional modulation on the sentential-level tracking being larger for younger than for older ones. Notably, the neuro-behavior analyses showed that subjects’ behavioral accuracy was positively correlated with the higher-level linguistic tracking, reversely correlated with the lower-level linguistic tracking. Overall, these results suggest that the enhanced lower-level linguistic tracking, reduced higher-level linguistic tracking and less flexibility of attentional modulation may underpin aging-related decline in speech comprehension.
Increased noise relates to abnormal excitation-inhibition balance in schizophrenia: a combined empirical and computational study
Authors: Abbasi Samira , Wolff Annemarie , Çatal Yasir , Northoff Georg 
Published: August 2023

Abstract
Electroencephalography studies link sensory processing issues in schizophrenia to increased noise level—noise here is background spontaneous activity—as measured by the signal-to-noise ratio. The mechanism, however, of such increased noise is unknown. We investigate if this relates to changes in cortical excitation-inhibition balance, which has been observed to be atypical in schizophrenia, by combining electroencephalography and computational modeling. Our electroencephalography task results, for which the local field potentials can be used as a proxy, show lower signal-to-noise ratio due to higher noise in schizophrenia. Both electroencephalography rest and task states exhibit higher levels of excitation in the functional excitation-inhibition (as a proxy of excitation-inhibition balance). This suggests a relationship between increased noise and atypical excitation in schizophrenia, which was addressed by using computational modeling. A Leaky Integrate-and-Fire model was used to simulate the effects of varying degrees of noise on excitation-inhibition balance, local field potential, NMDA current, and . Results show a noise-related increase in the local field potential, excitation in excitation-inhibition balance, pyramidal NMDA current, and spike rate. Mutual information and mediation analysis were used to explore a cross-level relationship, showing that the cortical local field potential plays a key role in transferring the effect of noise to the cellular population level of NMDA.
Accelerating knowledge translation to improve cardiovascular outcomes and health services: opportunities for bridging science and clinical practice
Authors: Lauck Sandra B , Saarijärvi Markus , De Sousa Ismália , Straiton Nicola , Borregaard Britt , Lewis Krystina B 
Published: August 2023

Abstract
Knowledge translation (KT) is the exchange between knowledge producers and users to understand, synthesize, share, and apply evidence to accelerate the benefits of research to improve health and health systems. Knowledge translation practice (activities/strategies to move evidence into practice) and KT science (study of the methodology and approaches to promote the uptake of research) benefit from the use of conceptual thinking, the meaningful inclusion of patients, and the application of intersectionality. In spite of multiple barriers, there are opportunities to develop strong partnerships and evidence to drive an impactful research agenda and increase the uptake of cardiovascular research.
Crustal and uppermost mantle structures imaged by teleseismicP-wave traveltime tomography beneath the Southeastern Korean Peninsula: implications for a hydrothermal system controlled by the thermally modified lithosphere
Authors: Lee Sungho , Song Jung-Hun , Heo Dabeen , Rhie Junkee , Kang Tae-Seob , Choi Eunseo , Kim YoungHee , Kim Kwang-Hee , Ree Jin-Han 
Published: August 2023

SUMMARYThe southeastern Korean Peninsula (SeKP) has experienced intense deformation owing to subduction and backarc extension at the eastern continental margin of the Eurasian Plate, leading to the formation of complex tectonic structures. Abnormally high surface heat flux, Cenozoic volcanism, signatures of mantle degassing and hydrothermal alteration, and several active fault systems with extensional sedimentary basins have been identified; however, the major driving forces that promote local seismic events and hydrothermal activities remain enigmatic. Here, we constructed 3-D P-wave velocity of the crust and upper mantle in the SeKP for the first time using a teleseismic traveltime tomography method and an extensive data set obtained from a dense seismic network. Our model revealed three distinct velocity patterns at different depths: (1) in the upper crust (depth ∼0–10 km), a low-velocity anomaly beneath the Cenozoic sedimentary basin exhibiting a prominent lateral velocity contrasts with higher velocities in the Cretaceous sedimentary and plutonic rocks; (2) a N–S trending low-velocity anomaly extending from the lower crust to the uppermost mantle (depth ∼20–35 km) beneath the major active fault systems interpreted as a thermally or mechanically weakened structure that could transfer high surface heat flux and transport mantle-driven gases and (3) a low-velocity anomaly adjacent to the Cenozoic basin in the upper mantle at depths of 35–55 km interpreted as the higher temperature upper mantle. Via a series of geodynamic simulations, we demonstrated that the extensional deformation at the eastern continental margin during the Early to Middle Miocene locally enhanced the temperature of the crust and upper mantle beneath the SeKP. We propose that a hydrothermal system, resulting from the thermally modified lithosphere of the continental margin, has contributed to the enhanced local seismicity and geothermal activities observed in the SeKP region.