bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of antibody response to coronavirus disease 2019 vaccination between patients with solid or hematologic cancer patients undergoing chemotherapy
Authors: Lim Sung Hee , Choi Seong Hyeok , Ji Young Sok , Kim Se Hyung , Kim Chan Kyu , Yun Jina , Park Seong Kyu 
Published: April 2023

AbstractAimThis study examined the serum antibody response of coronavirus disease 2019 (COVID‐19) vaccines in solid and hematologic cancer patients undergoing chemotherapy. Levels of various inflammatory cytokines/chemokines after full vaccination were analyzed.MethodsForty‐eight patients with solid cancer and 37 with hematologic malignancy who got fully vaccinated either with severe acute respiratory syndrome coronavirus 2 messenger RNA (mRNA) or vector vaccines or their combination were included. After consecutively collecting blood, immunogenicity was assessed by surrogate virus neutralization test (sVNT), and cytokine/chemokines were evaluated by Meso Scale Discovery assay.ResultsSeropositivity and protective immune response were lower in patients with hematologic cancer compared to those with solid cancers, regardless of vaccine type. Significantly lower sVNT inhibition was observed in patients with hematologic cancer (mean [SD] 45.30 [40.27] %) than in those with solid cancer (mean [SD] 61.78 [34.79] %) (p = 0.047). Heterologous vector/mRNA vaccination was independently and most markedly associated with a higher sVNT inhibition score (p < 0.05), followed by homologous mRNA vaccination. The mean serum levels of tumor necrosis factor α, macrophage inflammatory protein (MIP)‐1α, and MIP‐1β were significantly higher in patients with hematologic cancers compared to those with solid cancers after the full vaccination. In 36 patients who received an additional booster shot, 29 demonstrated increased antibody titer in terms of mean sVNT (%) (40.80 and 75.21, respectively, before and after the additional dose, p < 0.001).ConclusionHematologic cancer patients receiving chemotherapy tended to respond poorly to both COVID‐19 mRNA and vector vaccines and had a significantly lower antibody titer compared to those with solid cancers.
Epithelium‐derived cystatin SN inhibits house dust mite protease activity in allergic asthma
Authors: Yao Lei , Yuan Xijing , Fu Heng , Guo Qinxing , Wu Yunhui , Xuan Shurui , Kermani Nazanin Zounemat , Adcock Ian M. , Zeng Xiaoning , Liu Yi , Xie Min , Yao Xin 
Published: April 2023

AbstractBackgroundAllergen source‐derived proteases are a critical factor in the formation and development of asthma. The cysteine protease activity of house dust mite (HDM) disrupts the epithelial barrier function. The expression of cystatin SN (CST1) is elevated in asthma epithelium. CST1 inhibits the cysteine protease activity. We aimed to elucidate the role of epithelium‐derived CST1 in the development of asthma caused by HDM.MethodsCST1 protein levels in sputum supernatants and serum of patients with asthma and healthy volunteers were measured by ELISA. The ability of CST1 protein to suppress HDM‐induced bronchial epithelial barrier function was examined in vitro. The effects of exogenous CST1 protein on abrogating HDM‐induced epithelial barrier function and inflammation were examined in mice in vivo.ResultsCST1 protein levels were higher in sputum supernatants (142.4 ± 8.95 vs 38.87 ± 6.85 ng/mL, P < 0.0001) and serum (1129 ± 73.82 vs 703.1 ± 57.02 pg/mL, P = 0.0035) in patients with asthma than in healthy subjects. The levels were significantly higher in patients with not well‐ and very poorly controlled asthma than those with well‐controlled asthma. Sputum and serum CST1 protein levels were negatively correlated with lung function in asthma. CST1 protein levels were significantly lower in the serum of HDM‐specific IgE (sIgE)‐positive asthmatics than in sIgE‐negative asthmatics. The HDM‐induced epithelial barrier function disruption was suppressed by recombinant human CST1 protein (rhCST1) in vitro and in vivo.ConclusionOur data indicated that human CST1 protein suppresses asthma symptoms by protecting the asthmatic bronchial epithelial barrier through inhibiting allergenic protease activity. CST1 protein may serve as a potential biomarker for asthma control.
How vicarious experiences influence non‐compliance with COVID‐19 prevention regulations
Authors: Miao Qing , Huang Jinhao , Yin Hui 
Published: April 2023

AbstractIn the wake of the COVID‐19 pandemic, most countries have adopted strict regulation strategies such as travel restrictions, gathering restrictions, and daily health reporting. With the normalization of the pandemic, people have shown resistance to these highly intensive regulations. Yet few studies have explored the mechanisms of behavioral change from compliance to non‐compliance from the perspective of vicarious experiences. Based on the social cognitive theory, we constructed a model linking vicarious experiences, risk perception, and non‐compliance behavior to reveal the mechanism of why individuals do not comply with pandemic prevention rules and regulations. A sample of 1080 Chinese participants was obtained from a time lagged design. The results indicated that vicarious experiences could influence non‐compliance with prevention rules and regulations via perceived probability and perceived consequence of being caught. In addition, public trust in the government could negatively moderate the direct effect of the intention of violating prevention rules and regulations on non‐compliance. This direct effect is stronger for citizens with low levels of public trust in the government than for those with high levels. Our findings advance the understanding of the mechanisms behind the way vicarious experiences affect citizens’ non‐compliance behavior with COVID‐19 prevention rules and regulations.
Oxidized soluble guanylyl cyclase causes erectile dysfunction in alcoholic mice
Authors: Olivencia Miguel A. , Gil de Biedma‐Elduayen Leticia , Giménez‐Gómez Pablo , Barreira Bianca , Fernández Argentina , Angulo Javier , Colado Maria Isabel , O'Shea Esther , Perez‐Vizcaino Francisco 
Published: April 2023

Background and purposeAlcohol abuse has been associated with erectile dysfunction (ED), but the implicated molecular mechanisms are unresolved. This study analyses the role of alterations in soluble guanylyl cyclase (sGC) in ED.Experimental approachED was analysed in adult male C57BL/6J mice subjected to the Chronic Intermittent Ethanol (CIE) paradigm. Erectile function was assessed in anaesthetised mice in vivo by evaluating intracavernosal pressure (ICP) and in vitro in isolated mice corpora cavernosa (CC) mounted in a myograph. Protein expression and reactive oxygen species were analysed by western blot and dihydroethidium staining, respectively.Key resultsIn CIE mice, we observed a significant decrease in the relaxant response of the CC to stimulation of NO release from nitrergic nerves by electrical field stimulation, to NO release from endothelial cells by acetylcholine, to the PDE5 inhibitor sildenafil, and to the sGC stimulator riociguat. Conversely, the response to the sGC activator cinaciguat, whose action is independent of the oxidation state of sGC, was significantly enhanced in these CC. The responses to adenylyl cyclase stimulation with forskolin were unchanged. We found an increase in reactive oxygen species in the CC from CIE mice as well as an increase in CYP2E1 and NOX2 protein expression. In vivo pre‐treatment with tempol prevented alcohol‐induced erectile dysfunction.Conclusions and implicationsOur results demonstrate that alcoholic mice show ED in vitro and in vivo due to an alteration in the redox state of sGC and suggest that sGC activators may be effective in ED associated with alcoholism.
Establishment and characterization of a novel cancer stem‐like cell of cholangiocarcinoma
Authors: Panawan Orasa , Silsirivanit Atit , Chang Chih‐Hsiang , Putthisen Siyaporn , Boonnate Piyanard , Yokota Taro , Nishisyama‐Ikeda Yuki , Detarya Marutpong , Sawanyawisuth Kanlayanee , Kaewkong Worasak , Muisuk Kanha , Luang Sukanya , Vaeteewoottacharn Kulthida , Kariya Ryusho , Yano Hiromu , Komohara Yoshihiro , Ohta Kunimasa , Okada Seiji , Wongkham Sopit , Araki Norie 
Published: April 2023

AbstractCholangiocarcinoma (CCA) is an aggressive malignant tumor of bile duct epithelia. Recent evidence suggests the impact of cancer stem cells (CSC) on the therapeutic resistance of CCA; however, the knowledge of CSC in CCA is limited due to the lack of a CSC model. In this study, we successfully established a stable sphere‐forming CCA stem‐like cell, KKU‐055‐CSC, from the original CCA cell line, KKU‐055. The KKU‐055‐CSC exhibits CSC characteristics, including: (1) the ability to grow stably and withstand continuous passage for a long period of culture in the stem cell medium, (2) high expression of stem cell markers, (3) low responsiveness to standard chemotherapy drugs, (4) multilineage differentiation, and (5) faster and constant expansive tumor formation in xenograft mouse models. To identify the CCA‐CSC‐associated pathway, we have undertaken a global proteomics and functional cluster/network analysis. Proteomics identified the 5925 proteins in total, and the significantly upregulated proteins in CSC compared with FCS‐induced differentiated CSC and its parental cells were extracted. Network analysis revealed that high mobility group A1 (HMGA1) and Aurora A signaling through the signal transducer and activator of transcription 3 pathways were enriched in KKU‐055‐CSC. Knockdown of HMGA1 in KKU‐055‐CSC suppressed the expression of stem cell markers, induced the differentiation followed by cell proliferation, and enhanced sensitivity to chemotherapy drugs including Aurora A inhibitors. In silico analysis indicated that the expression of HMGA1 was correlated with Aurora A expressions and poor survival of CCA patients. In conclusion, we have established a unique CCA stem‐like cell model and identified the HMGA1‐Aurora A signaling as an important pathway for CSC‐CCA.
Two‐Step Training: Adjustable Sketch Colourization via Reference Image and Text Tag
Authors: Yan Dingkun , Ito Ryogo , Moriai Ryo , Saito Suguru 
Published: April 2023

AbstractAutomatic sketch colourization is a highly interestinged topic in the image‐generation field. However, due to the absence of texture in sketch images and the lack of training data, existing reference‐based methods are ineffective in generating visually pleasant results and cannot edit the colours using text tags. Thus, this paper presents a conditional generative adversarial network (cGAN)‐based architecture with a pre‐trained convolutional neural network (CNN), reference‐based channel‐wise attention (RBCA) and self‐adaptive multi‐layer perceptron (MLP) to tackle this problem. We propose two‐step training and spatial latent manipulation to achieve high‐quality and colour‐adjustable results using reference images and text tags. The superiority of our approach in reference‐based colourization is demonstrated through qualitative/quantitative comparisons and user studies with existing network‐based methods. We also validate the controllability of the proposed model and discuss the details of our latent manipulation on the basis of experimental results of multi‐label manipulation.
Age, period and cohort effects on time trends in monthly cannabis use in adult population: 1996–2019
Authors: Nigatu Yeshambel T. , Elton‐Marshall Tara , Rueda Sergio , Imtiaz Sameer , Hamilton Hayley A. 
Published: April 2023

AbstractIntroductionWith changes in norms related to cannabis use and in the regulation of cannabis, understanding trends in cannabis use is important, especially differentiating between trends that affect cohorts of all ages similarly, versus trends that disproportionately affect a younger generation. The present study examined the age‐period‐cohort (APC) effects on monthly cannabis use among adults in Ontario, Canada over a 24‐year period.MethodsData were utilised from the Centre for Addiction and Mental Health Monitor Survey, an annual repeated cross‐sectional survey of adults 18 years of age and older. The present analyses focused on the 1996 to 2019 surveys, which employed a regionally stratified sampling design using computer‐assisted telephone interviews (N = 60,171). Monthly use of cannabis stratified by sex were examined.ResultsThere was about a five‐fold increase in monthly cannabis use from 1996 (3.1%) to 2019 (16.6%). The youngest adults use cannabis monthly more, but the patterns of monthly cannabis use appeared to be increasing among older adults. Adults born in the 1950s had higher prevalence of cannabis use (1.25 times more likely to use) compared to those born in 1964, with strongest period effect in 2019. The subgroup analysis of monthly cannabis use by sex showed little variation in APC effects.Discussion and ConclusionsThere is a change in patterns of cannabis use among older adults and inclusion of birth cohort dimension improves the explanation of cannabis use trends. Adults in the 1950s birth cohort and increases in the normalisation of cannabis use could also be the key to explaining increasing monthly cannabis use.
“And Yet It Moves”: Dream and Reality of the Ecumenical Movement
Authors: Werner Dietrich 
Published: April 2023

AbstractThis article offers an overview of the 11th Assembly of the World Council of Churches, which met in Karlsruhe, Germany, in August–September 2022. It sets out the context in which the assembly took place, the main issues discussed, and perspectives for the future. The article argues that the assembly in Karlsruhe demonstrated that the ecumenical movement still is alive and can offer enormous potential in a world at the brink of a new East–West divide, facing a significant weakening of multilateral structures of cooperation, and even the threat of nuclear war. Moreover, the Karlsruhe assembly demonstrated that on subjects such as the Middle East, peace ethics, and nationalism, and in the deep commitment and spiritual life of its participants, the ecumenical movement is vital and vibrant and represents a countercultural force against rigid nationalisms.
Homily at the Opening Prayer of the 11th Assembly of the World Council of Churches
Authors: X Patriarch John 
Published: April 2023

AbstractThis is the text of the homily at the opening prayer of the 11th Assembly of the World Council of Churches on 31 August 2022. The homily was based on Jesus' encounter with the Samaritan woman at the well, a narrative in the fourth chapter of the Gospel of John. Despite wide gaps of religious belief, gender, culture, and lifestyle, Jesus took the woman seriously and spoke to her on a personal level.
What is the real perversity of racism?
Authors: Prasad Ajnesh 
Published: April 2023

AbstractRacism is inscribed onto the mind of the racialized subject. This essay represents my attempt at making sense of the psychological costs levied by the racism that materializes from living in a culture of hegemonic whiteness. My analysis is informed by Frantz Fanon's writings and, particularly, his concept of corporeal malediction. Corporeal malediction captures the unique reality of the racialized subject—one that is different from the systemic discrimination and violence encountered by other socially disenfranchised groups. Theoretically framed by Fanon's “postcolonial” thought, and anecdotally informed by my own experiences as well as my past research on race and racism in organizations, I pose the question: What is the real perversity of racism? I argue that the real perversity of racism is to be found in the psychological damage that it poses on the ontology of the racialized subject. This psychological damage on the racialized subject unfolds through myriad trajectories, three of which I identify in this essay: (1) the (dis)coloring of social reality, (2) the impossibility of assimilation, and (3) the hybrid identity problematic. While management and organization studies researchers have expended much energy in unraveling the institutional and the organizational paths through which racism is enacted, there has been a dearth of scholarly research on its devastating impact on the psychology of the individual. This essay aims to flesh out this corporeal phenomenon.
A robust examination of COVID‐19 and country risk: Perspectives from the G10 countries
Authors: Eldomiaty Tarek , Abdelhameed Yasmin , Hammam Rasha 
Published: April 2023

AbstractThis paper examines the effects of COVID‐19 new infections on the financial sovereign risks in the group of ten (G10) countries. The paper utilises panel least squares regression using monthly data over the period February 2020–July 2021. Two sovereign risk measures are examined: the Spread of Government Bond Yields and Sovereign Credit Default Swap spread. The results of the robustness tests show that the spread of the COVID‐19 has affected the sovereign risks significantly and positively. Contagion risks have been extended to exchanges rates and growth rates of international reserves. This paper offers two contributions. First, the results show robust evidence on the impact of COVID‐19 on country's sovereign risks. Second, the severity of COVID‐19 on country's sovereign risks is further. The empirical results carry policy implications that (a) countries must sustain efforts for safeguarding the evolution of COVID‐19 pandemic since it is hindering country's credit worthiness, thus increasing sovereign risks, (b) the G10 countries are advised to follow the zero COVID‐19 strategy, (c) macro prudential measures have to be implemented along with monetary policies that mitigate the sovereign risks and (d) implement social measures to restore the health system and contain the uncertainty on both economic and social grounds.
Is homestay service an ideal business opportunity for women?
Authors: Yaja Millo , Kumar Anuj , Swamy G. Anjaneya , Rout Himanshu Bhusan 
Published: April 2023

AbstractHomestay services are one of the booming concepts for local community participation in the tourism industry. Participation of women in community‐based tourism activities is getting attention from academic stakeholders, but the women in the homestay services section need special focus. Hence, this study explores the opinions of female homestay service providers about their experiences in running homestays. In this study, 62 women were interviewed in the state of Arunachal Pradesh, India. The study extracted women's perceptions of homestay service in tourism. A semi‐structured questionnaire, interviews and participant observations were used to collect primary data. Homestay service is found to be an ideal profession for married women as it gives them the opportunity to fulfil other family duties, though it is not a compulsion in all cases. Women were also found to feel a sense of recognition through such participation in tourism. Participating in homestay services was found to be a source of meeting peers, building social networks and a sense of exposure to the outside world. The findings of the study will be insightful for implementing schemes related to women's empowerment and rural development. These findings confirm the mass migration of the rural population towards metro cities can also be curved by engaging more people in tourism and allied businesses locally.
Impact of different drying techniques on grapefruit peels and subsequent optimization of ultrasonic extraction conditions for bioactive compounds
Authors: Islam Makdud , Malakar Santanu , Dwivedi Utkarsh , Kumar Nitin , Prabakar Pramod K. , Kishore Anand , Kumar Ankur 
Published: April 2023

AbstractThis research aims to investigate the effect of different drying methods on the phytochemical compounds of grapefruit peels and the subsequent optimization of ultrasonicated assisted extraction conditions for bioactive compounds. Based on the maximum retention of phenolic compounds and naringin content, the hot air‐drying approach was selected for optimization of extraction process. The Box–Behnken design was used for ultrasonic‐assisted extraction (UAE) of bioactive compounds from hot air‐dried peel powder. Three factors such as solvent concentration (SC), ultrasonic amplitude (UA), and sonication time (ST) were considered for optimize the extraction condition based on total phenolic content (TPC), total flavonoid content (TFC), naringin content, and total antioxidant activities (TAA). UV‐spectrophotometric and HPLC was used for the determination in this study. The results revealed that UA and ST had significant effects on all the extraction responses. Based on the numerical optimization, the optimum extraction condition was found to be 48% (v/v) ethanol concentration, 40% ultrasonic amplitude, and 13 min sonication time. The respective optimum phytochemicals and antioxidant activity responses were obtained as TPC (78.5 mg GAE/g dw), TFC (53.5 mg naringin/g dw), naringin content (40.8 mg/g dw), and total antioxidant activities by DPPH assay (25.5 mM Trolox/g dw), ABTS*+ assay (4050 mM Trolox/100 g dw) and FRAP assay (17.45 Fe [II]/g dw).Practical ApplicationsFruit peels are a rich and valuable bioactive residue obtained from the various juice and beverage processing industries. Grapefruit peels are an abundant source of antioxidants and bioflavonoids such as naringin and hesperidin, which have huge potential as a functional ingredients. The optimum extraction condition obtained by this UAE technique has higher levels of polyphenolic compounds and flavonoids, particularly naringin, which shows a wide range of applications in the pharmaceutical sector and might be a way towards its effective sources of utilization in functional foods.
Creating an Alianza: Group Perinatal Education for Newly Immigrated Latinx Pregnant People
Authors: Blumenfeld Julie , Kaufman Sheila , Raimundi‐Petroski Maritza 
Published: April 2023

AbstractPregnant people who are recent immigrants often face barriers navigating the health care system and establishing a support network to sustain them through pregnancy and new parenthood. The Cultivando una Nueva Alianza (CUNA) program from the Children's Home Society of New Jersey was created to address these obstacles. For over 20 years, CUNA has collaborated with local midwives to develop a program for newly immigrated, Spanish‐speaking Latinx pregnant people. The curriculum, facilitated by trained members of the community, provides education around pregnancy, birth, and early parenting and connects participants with prenatal care and community resources while cultivating a social support network. The program's success is seen in improved clinical outcomes, ongoing involvement by graduates, and strong continued support from community stakeholders. The CUNA program has been replicated in nearby communities and offers a blueprint for a low‐tech intervention to improve the health and wellness of this population.