bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of cerebellar transcranial alternating current stimulation in cerebellar ataxia: study protocol for a randomised controlled trial
Authors: Liu Xia , Lin Wei , Zhang Lin , Zhang Wan-Li , Cheng Xiao-Ping , Lian Yan-Hua , Li Meng-Cheng , Wang Shi-Zhong , Chen Xin-Yuan , Gan Shi-Rui 
Published: April 2023

BackgroundCerebellar ataxia (CA) is a movement disorder that can affect balance and gait, limb movement, oculomotor control, and cognition. Multiple system atrophy-cerebellar type (MSA-C) and spinocerebellar ataxia type 3 (SCA3) are the most common forms of CA, for which no effective treatment is currently available. Transcranial alternating current stimulation (tACS) is a non-invasive method of brain stimulation supposed to alter cortical excitability and brain electrical activity, modulating functional connectivity within the brain. The cerebellar tACS can modulate the cerebellar outflow and cerebellum-linked behavior and it is a proven safe technique for humans. Therefore, the aim of this study is to 1) examine whether cerebellar tACS improves ataxia severity and various non-motor symptoms in a homogeneous cohort of CA patients consisting of MSA-C and SCA3, 2) explore the time course of these effects, and 3) assess the safety and tolerance of cerebellar tACS in all participants.Methods/designThis is a 2-week, triple-blind, randomised, sham-controlled study. 164 patients (MSA-C: 84, SCA3: 80) will be recruited and randomly assigned to either active cerebellar tACS or sham cerebellar tACS, in a 1:1 ratio. Patients, investigators, and outcome assessors are unaware of treatment allocation. Cerebellar tACS (40 min, 2 mA, ramp-up and down periods of 10s each) will be delivered over 10 sessions, distributed in two groups of five consecutive days with a two-day break in between. Outcomes are assessed after the tenth stimulation (T1), and after 1 month (T2) and 3 months (T3). The primary outcome measure is the difference between the active and sham groups in the proportion of patients with an improvement of 1.5 points in the Scale for the Assessment and Rating of Ataxia (SARA) score after 2 weeks of treatment. In addition, effects on a variety of non-motor symptoms, quality of life, and autonomic nerve dysfunctions are assessed via relative scales. Gait imbalance, dysarthria, and finger dexterity are objectively valued via relative tools. Finally, functional magnetic resonance imaging is performed to explore the possible mechanism of treatment effects.DiscussionThe results of this study will inform whether repeated sessions of active cerebellar tACS benefit CA patients and whether this form of non-invasive stimulation might be a novel therapeutic approach to consider in a neuro-rehabilitation setting.Clinical Trial Registration: ClinicalTrials.gov, identifier NCT05557786; https://www.clinicaltrials.gov/ct2/show/NCT05557786.
The complementary role of MRI and FET PET in high-grade gliomas to differentiate recurrence from radionecrosis
Authors: Sahu Arpita , Mathew Ronny , Ashtekar Renuka , Dasgupta Archya , Puranik Ameya , Mahajan Abhishek , Janu Amit , Choudhari Amitkumar , Desai Subhash , Patnam Nandakumar G. , Chatterjee Abhishek , Patil Vijay , Menon Nandini , Jain Yash , Rangarajan Venkatesh , Dev Indraja , Epari Sridhar , Sahay Ayushi , Shetty Prakash , Goda Jayant , Moiyadi Aliasgar , Gupta Tejpal 
Published: April 2023

IntroductionConventional magnetic resonance imaging (MRI) has limitations in differentiating tumor recurrence (TR) from radionecrosis (RN) in high-grade gliomas (HGG), which can present with morphologically similar appearances. Multiparametric advanced MR sequences and Positron Emission Tomography (PET) with amino acid tracers can aid in diagnosing tumor metabolism. The role of both modalities on an individual basis and combined performances were investigated in the current study.Materials and MethodsPatients with HGG with MRI and PET within three weeks were included in the retrospective analysis. The multiparametric MRI included T1-contrast, T2-weighted sequences, perfusion, diffusion, and spectroscopy. MRI was interpreted by a neuroradiologist without using information from PET imaging. 18F-Fluoroethyl-Tyrosine (FET) uptake was calculated from the areas of maximum enhancement/suspicion, which was assessed by a nuclear medicine physician (having access to MRI to determine tumor-to-white matter ratio over a specific region). A definitive diagnosis of TR or RN was made based on the combination of multidisciplinary joint clinic decisions, histopathological examination, and clinic-radiological follow-up as applicable.Results62 patients were included in the study between July 2018 and August 2021. The histology during initial diagnosis was glioblastoma, oligodendroglioma, and astrocytoma in 43, 7, and 6 patients, respectively, while in 6, no definitive histological characterization was available. The median time from radiation (RT) was 23 months. 46 and 16 patients had TR and RN recurrence, respectively. Sensitivity, specificity, and accuracy using MRI were 98, 77, and 94%, respectively. Using PET imaging with T/W cut-off of 2.65, sensitivity, specificity, and accuracy were 79, 84, and 80%, respectively. The best results were obtained using both imaging combined with sensitivity, specificity, and accuracy of 98, 100, and 98%, respectively.ConclusionCombined imaging with MRI and FET-PET offers multiparametric assessment of glioma recurrence that is correlative and complimentary, with higher accuracy and clinical value.
Microwave ablation induces abscopal effect via enhanced systemic antitumor immunity in colorectal cancer
Authors: Yu Lu , Xie Hairong , Wang Linping , Cheng Min , Liu Jie , Xu Jiamei , Wei Zhigang , Ye Xin , Xie Qi , Liang Jing 
Published: April 2023

BackgroundThermal ablation is the primary procedure for the local treatment of lung metastases. It is known that radiotherapy and cryoablation can stimulate an abscopal effect, while the occurrence of abscopal effect induced by microwave ablation is less; the cellular and molecular mechanisms involved in the abscopal effect after microwave ablation should be further elucidated.MethodsCT26 tumor-bearing Balb/c mice were treated with microwave ablation with several combinations of ablation power and time duration. The growth of primary or abscopal tumors and the survival of mice were both monitored; moreover, immune profiles in abscopal tumors, spleens, and lymph nodes were examined by flow cytometry.ResultsMicrowave ablation suppressed tumor growth in both primary and abscopal tumors. Both local and systemic T-cell responses were induced by microwave ablation. Furthermore, the mice exhibiting significant abscopal effect after microwave ablation markedly elevated Th1 cell proportion both in the abscopal tumors and spleens.ConclusionsMicrowave ablation at 3 w–3 min not only suppressed tumor growth in the primary tumors but also stimulated an abscopal effect in the CT26-bearing mice via the improvement of systemic and intratumoral antitumor immunity.
Predicting social skills in disadvantaged Chinese high school students through physical education
Authors: Primo Laura , González-Hernández Juan , Yang Yin , López de Subijana Cristina 
Published: April 2023

IntroductionThis study analyzed the relationships between social skills and motivation to Physical Education, students´ perceived support regarding Physical Education lessons (from parents, teachers and peers) and basic needs satisfaction in a sample of disadvantaged high school Chinese students according to Self-Determination Theory-related main principles. Physical Education classes are a great opportunity to develop not only psychomotor and physiologically, but also psychosocially in young people, and that is why this study investigates the relationship between the social skills of the students and these other main variables of the Self-Determination Theory.MethodsTwo hundred and nine disadvantaged students enrolled in a camp organized by a non-governmental organization in Chengdu province (15.9 ± 0.83 years; 73.9% female and 26.1% male) completed the Chinese versions of the following Self-Determination Theory-related questionnaires (independent variables): Learning Climate Questionnaire, Activity- Feeling States Scale, Perceived Locus of Causality scale; and social skills questionnaire (dependent variable): Matson Evaluation of Social Skills with Youngsters Scale.ResultsThe standard multiple regression model to predict social skills based on perceived support, basic needs satisfaction and motivation towards Physical Education was significant (F(11, 195)= 13.85; p &lt; .001; R2=.44; Cohen’s f2= 0.78). The social skills of the students were positively related to peer support and relatedness subscales. In contrast, introjected regulation, external regulation, and amotivation were adversely correlated with social skills.DiscussionWe believe that this information would help policymakers and teachers design new policies, actions, and teaching methodologies to implement for the development of Physical Education and sport programs in China, those that will help young people throughout their life span.
Effects of household access to water, sanitation, and hygiene services on under-five mortality in Sub-Saharan Africa
Authors: Gaffan Nicolas , Kpozehouen Alphonse , Degbey Cyriaque , Ahanhanzo Yolaine Glele , Paraïso Moussiliou Noël 
Published: April 2023

IntroductionSub-Saharan Africa has the highest under-five mortality rate and is among the regions where people have the least access to adequate Water, Sanitation, and Hygiene (WASH) services. The work aimed to investigate the effects of WASH conditions faced by children on under-five mortality in Sub-Saharan Africa.MethodsWe carried out secondary analyses using the Demographic and Health Survey datasets of 30 countries in Sub-Saharan Africa. The study population consisted of children born within 5 years preceding the selected surveys. The dependent variable was the child’s status (1 = deceased versus 0 = alive) on the survey day. The individual WASH conditions in which children live were assessed in their immediate environment, i.e., at the level of their households of residence. The other explanatory variables were related to the child, mother, household, and environment. Following a description of the study variables, we identified the predictors of under-five mortality using a mixed logistic regression.ResultsThe analyses involved 303,985 children. Overall, 6.36% (95% CI = 6.24–6.49) of children died before their fifth birthday. The percentage of children living in households with access to individual basic WASH services was 58.15% (95% CI = 57.51–58.78), 28.18% (95% CI = 27.74–28.63), and 17.06% (95% CI = 16.71–17.41), respectively. Children living in households using unimproved water facilities (aOR = 1.10; 95% CI = 1.04–1.16) or surface water (aOR = 1.11; 95% CI = 1.03–1.20) were more likely to die before five than those coming from households with basic water facilities. The risk of under-five mortality was 11% higher for children living in households with unimproved sanitation facilities (aOR = 1.11; 95% CI = 1.04–1.18) than for those with basic sanitation services. We found no evidence to support a relationship between household access to hygiene services and under-five mortality.ConclusionInterventions to reduce under-five mortality should focus on strengthening access to basic water and sanitation services. Further studies are needed to investigate the contribution of access to basic hygiene services on under-five mortality.
Recurrent paratesticular giant liposarcoma: A case report and literature review
Authors: Hua Runmiao , Zhao Liwei , Xu Li , Sun Ji , Huang Jiaguo , Hua Qiyan 
Published: April 2023

BackgroundPrimary paratesticular liposarcoma is rarely diagnosed among urinary tumors. In this study, through the retrospective analysis of clinical data and literature review, a case of recurrent paratesticular liposarcoma with lymph node metastasis after radical resection has been reported to explore novel strategies for the diagnosis, treatment and prognosis of this rare disease.Case summaryThe present case involved a patient who was misdiagnosed as a left inguinal hernia for the first time two years ago, but was later diagnosed as mixed liposarcoma by using postoperative pathology. Currently, he is readmitted to the hospital with a recurrence of the left scrotal mass for more than 1 year. Combined with the patient's past medical history, we performed radical resection of the left inguinal and scrotal tumors and lymphadenectomy of left femoral vein. The postoperative pathology indicated that well-differentiated liposarcoma was accompanied by mucinous liposarcoma (about 20%), and lymph node metastasis of left femoral vein both of which occurred at the same time. After the operation, we recommended the patient to receive further radiation therapy, but the patient and his family refused, hence we followed up the patient closely for a long time. During the recent follow-up, the patient reported no complaints of discomfort, and no recurrence of mass in the left scrotum and groin area.ConclusionAfter conducting extensive review of literature, we conclude that radical resection remains the key to treat primary paratesticular liposarcoma, while the significance of the lymph node metastasis is still unclear. The potential effects of postoperative adjuvant therapy depends on the pathological type, and hence close follow-up observation is essential.
Levantamento bibliográfico: principais fatores de lesões no ballet
Authors: De Souza Beatriz Rodrigues , Klimeki Eduarda Izabelle Fortes , Russo Fabricio da Silva , Chagas Gabriely Correia , Bueno Kawane , Da Silva Marielen Nayara , Safraiter Rodrigo Otavio 
Published: April 2023

As lesões causadas pela pratica de ballet assim como seus fatores de influência tem levantado questionamentos há algum tempo, com isso em mente esse trabalho foi realizado. Portanto, serão analisados artigos e pesquisas sobre esta temática, para melhor compreensão do assunto. Além disso, espera-se identificar a lesão com maior incidência e determinar suas características. Dessa forma, o estudo em questão é um levantamento de referencial teórico, com foco futuro no desenvolvimento de um artigo cientifico com pesquisa de campo, visando a identificação destes fatores na nossa região e na elaboração de meios de diminuição destes problemas.
Monitoria acadêmica: a importância do ensino de neuropsicologia na formação do psicólogo
Authors: Da Silva Andreza Mariz , Santos Ida Celine Gonçalves , Ferreira Sandra de Fátima Barboza 
Published: April 2023

Este trabalho constitui o relato de experiência das atividades de monitoria acadêmica realizadas na disciplina de Neuropsicologia do curso de Psicologia da Universidade Federal de Goiás. A monitoria acadêmica tem por objetivo o aprofundamento do aluno monitor em conhecimentos teórico-práticos dentro da disciplina vinculada; Incentivar e despertar o interesse pela docência, aperfeiçoando o desenvolvimento de competências; e auxiliar na interação dos estudantes e docentes nas atividades de ensino e aprendizagem. Tendo em vista que o objetivo da monitoria acadêmica é auxiliar os alunos com dificuldades no processo de aprendizado em neuropsicologia, esse relato de experiência tem por objetivo ressaltar a importância da monitoria acadêmica no ensino de neuropsicologia na formação do psicólogo bem como ressaltar práticas e alternativas utilizadas no acompanhamento de estudantes com necessidades específicas. Destacam-se aqui adaptações curriculares no nível da metodologia que permitem o acesso e acessibilidade desses alunos aos conteúdos da disciplina. Discute-se acerca do alcance e limites da atividade de monitoria. Conclui-se que, embora a adesão dos alunos não seja ampla, a monitoria permite ao aluno-monitor consolidar conhecimentos e experimentar o exercício de habilidades da docência, bem como cumprir a finalidade da monitoria no que tange ao apoio a alunos com necessidades específicas.
Vortex structure in relaxed BaTiO3/SrTiO3 superlattice
Authors: Yang Fengjuan , Liang Yongfeng , Wu Pingping 
Published: April 2023

Abstract
In this work, using the phase-field model, we demonstrated vortex structure can be generated in a lead-free BaTiO3/SrTiO3 superlattice structure. The labyrinth pattern (maze-like) domain structure was observed in a fully relaxed BaTiO3/SrTiO3 superlattice structure. Topological bubble-like rosette structures were found at an out-of-plane field, and polar skyrmions were obtained after the electric field was removed. In a designed fully relaxed nanowire of width ∼8 nm, near-perfect periodical clockwise-counterclockwise ferroelectric vortex pairs were generated due to the interfacial constraints. The simulated topological structures are potentially relevant to the application of high-density ferroelectrics memory devices.
Águas de Rita:
Authors: Santos de Matos Elisiane , Das Mercês Carvalho Ciro Antonio , Beck Maurício 
Published: April 2023

A presente comunicação intenta realizar uma análise espacial do texto Águas de Rita, de autoria de Belize Pombal, presente na coletânea erótica Além dos Quartos, em que tomamoscomo baseas relações singulares entre espaço, sexualidade, prazer e tecnologia presentes na obra Pornotopia de Preciado (2020). Antevendo e problematizando as diferenças conceituais entre o erótico e o pornográfico e, a partir dos estudos de Mota (2012), pelo viés da Análise de Discurso materialista, desconstruindo a ideia de uma fronteira rígida entre eles, pretendemos trabalhar em retrospecto o conceito de heterotopia presente na filosofia foucaultiana, tendo por base a análise de Preciado (2020) acerca do conceito de pornotopia. Em Águas de Rita, temos a representação de uma mulher negra, seus dilemas envolvendo sua sexualidade em um contexto urbano, de modo que buscamos compreender como se posicionam as identidades (BUTLER, 2017) subjetivas das mulheres negras, enquanto sujeitos e não como objetos eróticos, frente aos seus desejos, aos seus corpos e aos seus afetos. Para tanto, utilizamos também o arcabouço teórico presente nas obras de Preciado (2018); Kilomba (2019) e Maingueneau (2010).

Palavras-chave: mulheres negras; erotismo; crítica feminista; sexualidade.
O quanto 2020 nos interroga? O quanto Ensaio sobre a cegueira desvenda?
Authors: Kelm Miriam Denise , Paro Guilherme Henrique 
Published: April 2023

O artigo traz uma reflexão sobre as injunções entre um período singular como foi a eclosão da pandemia de Covid-19 em 2020 e a concomitante leitura da obra Ensaio sobre a cegueira, de José Saramago, realizada em sala de aula, no Curso de Licenciatura em Letras da Universidade Federal do Pampa. Para tanto, busca-se o referencial teórico ligado à formação do leitor literário, em seu percurso de amadurecimento e refinamento na recepção de obras ficcionais complexas e alegóricas. Oportuniza-se a retomada das discussões de ordem interativa: autor-texto-sociedade, reafirmando a completa simbiose das produções artísticas com o meio e os tempos que as proporcionam. Contempla-se em especial a percepção de um processo em curso, no próprio autor, de ceticismo crescente e implacabilidade do olhar diante da existência humana e, por fim, registra-se o aporte metodológico da escrita diarística, tornada tão significativa no período mencionado. Para tanto, recorre-se às memórias e entrevistas dadas por José Saramago; passa-se pela caracterização do diário nas palavras de Philippe Lejeune e Judith Butler; faz-se uma incursão no tema do engajamento do autor diante da historicidade, através de Jean-Paul Sartre e Simone de Beauvoir; insere-se considerações sobre a Literatura Portuguesa Contemporânea e sua atualidade e, por último, agrega-se à descrição do experimento pedagógico de leitura da obra saramagueana um relato do discente Guilherme Henrique Paro, revelando o grau de subjetividade envolvida e contribuindo para a legitimidade da experiência que motivou essa reflexão.
Analisis Peran Psikologi Komunikasi dalam Menganalisis Pola Pacaran Remaja
Authors: Andriany Dian , Wahyuningsih Olyvia , Najmatul Maulida Nasyfa , Shakira Lanora Tinanie Kirei 
Published: April 2023

Remaja merupakan masa transisi dari masa anak-anak ke masa dewasa yang mengalami perubahan begitu pesat. Remaja akan mengalami hal-hal yang belum pernah mereka alami sebelumnya, seperti menstruasi, mimpi basah, dorongan seksual, rasa tertarik atau malu terhadap lawan jenis, lebih sensitif, lebih tertutup pada orang tua, peningkatan kebutuhan akan kebebasan, lebih banyak memperhatikan penampilan diri dan sebagainya. Tujuan penelitian ini Mendiskripsikan perilaku pacaran pada remaja. Peneliti merasa penting menganalis perilaku berpacaran remaja. Metode yang dipakai melalui teknik penelitian kepustakaan (library study) yang mengacu pada sumber yang tersedia baik online maupun offline seperti: jurnal ilmiah, buku dan berita yang bersumber dari sumber terpercaya. Sehingga diperoleh kesimpulan bahwa remaja memiliki dua macam perilaku, yakni perilaku ketika berpacaraan berduaan dan perilaku pacaran berkelompok. Perilaku pacaran remaja ketika berduaan yakni dengan menghabiskan waktu untuk mengobrol berdua hingga perilaku berpelukan. Sedangkan perilaku pacaran remaja ketika bersama dengan teman-teman antara lain bertukar handphone dan nonton bioskop.
Pengaruh Ukuran Perusahaan, Profitabilitas dan Komite Audit terhadap Audit Report Lag
Authors: Martinus Hia Kevin , Pramukty Rachmat , Nirmala Kesumah 
Published: April 2023

Penelitian ini bertujuan untuk mengetahui bagaimana pengaruh ukuran perusahaan, profitabilitas dan komite audit terhadap audit report lag pada perusahaan manufaktur subsektor food & beverage yang terdaftar di Bursa Efek Indonesia (BEI) periode 2017-2021. Populasi dalam penelitian ini ialah perusahaan manufaktur sub sektor food & beverage yang terdaftar di Bursa Efek Indonesia periode 2017-2021. Pengambilan sampel dalam penelitian ini menggunakan metode purposive sampling. Penelitian ini dilakukan dengan metode kuantitatif dengan bantuan alat uji analisis yang digunakan adalah SmartPLS. Riset terdahulu atau riset yang relevan sangat penting dalam suatu riset atau artikel ilmiah. Riset terdahulu atau riset yang relevan berfungsi untuk memperkuat teori dan penomena hubungan atau pengaruh antar variable. Artikel ini mereview faktor-faktor yang memengaruhi terhadap audit report lag, yaitu ukuran perusahaan, profitabilitas dan komite audit, suatu studi literature audit. Tujuan penulisan artikel ini guna membangun hipotesis pengaruh antar variabel untuk digunakan pada riset selanjutnya. Hasil artikel literature review ini adalah: 1) ukuran perusahaan berpengaruh terhadap audit report lag; 2) profitabilitas berpengaruh terhadap audit report lag; dan 3) komite audit berpengaruh terhadap audit report lag.
Implementasi Standar Akuntansi Pemerintah, Sosialisasi Pelaporan Akuntansi Pemerintah, Penyetaraan Pelaporan pada Kantor Desa Karang Satria
Authors: Rahmawati Siti , Kuntadi Cris , Pramukty Rachmat 
Published: April 2023

Penelitian ini bertujuan untuk mengetaui pemahaman tentang implementasi standar akuntansi pemerintah, sosialisasi pelaporan akuntansi pemerintah, penyetaraan pelaporan pada kantor desa Karang Satria kecamatan Tambun Utara di Kabupaten Bekasi.Penelitian ini merupakan penelitian kuantitatif dengan pendekatan observasi dan wawancara. Pengumpulan data sekunder dilakukan dengan menyebarkan kuesioner, observasi, wawancara. Analisis data dilakukan menggunakan SPSS 24. Dan hasil menunjukan pelaporan keuangan yang valid untuk penyetaraan dan sosialisasi akuntansi pemerintahan. Artikel ini mereview faktor-faktor yang memengaruhi Penyetaraan Pelaporan Akuntansi, yaitu Implementasi Standar Akuntansi, Sosialisasi, dan Pelaporan Akuntansi Pemerintah. Tujuan penulisan artikel ini guna membangun hipotesis pengaruh antar variabel untuk digunakan pada riset selanjutnya. Hasil artikel literature review ini adalah: 1) Implementasi Standar Akuntansi berpengaruh terhadap Penyetraan Pelaporan Akuntansi; 2) Sosialisasi Pelaporan Akuntansi berpengaruh terhadap Penyetraan Pelaporan Akuntansi; dan 3) Pelaporan Akuntansi Pemerintah berpengaruh terhadap Penyetraan Pelaporan Akuntansi.