bluuebunny/crossref_metadata_2025_split huggingface dataset:
Increased Physiological GDNF Levels Have No Effect on Dopamine Neuron Protection and Restoration in a Proteasome Inhibition Mouse Model of Parkinson’s Disease
Authors: Olfat Soophie , Mätlik Kärt , Kopra Jaakko J. , Garton Daniel R. , Iivanainen Vilma H. , Bhattacharya Dipabarna , Jakobsson Johan , Piepponen T. Petteri , Andressoo Jaan-Olle 
Published: January 2023

AbstractParkinson’s disease (PD) is a progressive neurodegenerative disease that comprises a range of motor and nonmotor symptoms. Glial cell line-derived neurotrophic factor (GDNF) promotes the survival of dopamine neuronsin vitroandin vivo, and intracranial delivery of GDNF has been tested in six clinical trials for treating PD. However, clinical trials with ectopic GDNF have yielded variable results, which could in part result from abnormal expression site and levels caused by ectopic overexpression. Therefore, an important open question is whether an increase in endogenous GDNF expression could be potent in reversing PD progression. Here, we tested the therapeutic potential of endogenous GDNF using mice in which endogenous GDNF can be conditionally upregulated specifically in cells that express GDNF naturally (conditional GDNF hypermorphic mice;GdnfcHyper). We analyzed the impact of endogenous GDNF upregulation in both neuroprotection and neurorestoration procedures, and for both motor and nonmotor symptoms in the proteasome inhibitor lactacystin (LC) model of PD. Our results showed that upregulation of endogenous GDNF in the adult striatum is not protective in LC-induced PD model in mice. Since age is the largest risk factor for PD, we also analyzed the effect of deletion of endogenous GDNF in agedGdnfconditional knock-out mice. We found that GDNF deletion does not increase susceptibility to LC-induced damage. We conclude that endogenous GDNF does not impact the outcome in the LC-induced proteasome inhibition mouse model of Parkinson’s disease.
Rave Racing
Authors: Millea James 
Published: January 2023

In the origin story of futuristic racing game WipEout (Psygnosis, 1995), co-creator Nick Burcombe talks about turning down the game audio in Super Mario Kart (Nintendo, 1992) and substituting it for his own electronic dance music. Burcombe, who was himself a keen participant in the Liverpool rave scene, argues that people who went clubbing in the 1990s were always looking for new forms of interactive entertainment. WipEout, where players take control of anti-gravity ships and race them to the electronic dance music tracks of artists like Cold Storage, The Chemical Brothers, The Prodigy, and Orbital, was that next step in interactive entertainment.For its marketing campaign, WipEout’s packaging took its inspiration from dance music records and PlayStation installed consoles in nightclubs across the UK. In the follow-up to the original, WipEout 2097 or WipEout XL in North America (Psygnosis, 1996), players could put the game disk into a CD player and hear the soundtrack play out in its entirety, separate from the gameplay. Through a close textual analysis of the first and second versions of the game released on PlayStation, created as they were at the height of electronic dance music culture in the UK in the 1990s, and grounded in popular music studies and ludomusicology, this article inquires into the construction of the video game soundtrack, arguing that WipEout’s audiovisual relationship creates a space where players can become immersed in a rave-related experience of techno in their homes.The research finds that Burcombe and the team at Psygnosis set out not to replicate the rave experience in their video game. Rather, in WipEout, dance music is used to immerse players in a mediated extension of the contemporary UK rave venue or club. As players move their racers onscreen, they engage in actions that edge them closer to the game’s soundtrack itself, in its use of repetition and pulsating beats, as an embodied or corporeal performance. Rather than dancing to rave, WipEout’s players are gaming to techno.
Cuidados de enfermagem e posição prona: revisão integrativa
Authors: Zanchetta Flavia Cristina , Silva Juliany Lino Gomes , Pedrosa Rafaela Batista dos Santos , Oliveira-Kumakura Ana Railka de Souza , Gasparino Renata Cristina , Perissoto Samantha , Silva Vanessa Abreu , Lima Maria Helena de Melo 
Published: January 2023

Objetivo: explorar, na literatura científica, práticas atuais de cuidado de enfermagem ou intervenções para pacientes com síndrome respiratório agudo grave (SRAG) submetidos à posição prona.
Síntese do conteúdo: revisão integrativa, na qual foram realizadas buscas nas bases de dados PubMed, CINAHL, Scopus, Web of Science e LILACS em setembro de 2020 e janeiro de 2022, sem recorte temporal, por meio da questão deste estudo: “Quais são os cuidados de enfermagem para pacientes com SRAG submetidos à posição prona?”. Foram selecionados 15 artigos, a partir da busca nas bases de dados. Após a leitura, os cuidados encontrados foram categorizados em alinhamento do corpo para a prevenção de lesões neuromusculares, cuidados com equipamentos diversos, cuidados tegumentares e recomendações neurológicas.
Conclusões: o enfermeiro deve ter conhecimento sobre as implicações e as complicações de se manter um paciente na posição prona. Tal conhecimento permitirá tomadas de decisões na construção ou no seguimento de protocolos institucionais que contribuam com a prevenção de riscos e resultem em melhores desfechos para o paciente.
Characteristics of multiresistant Pseudomonas aeruginosa isolates from burn patients in Iran
Authors: Abednezhad Arash , Bakhshi Bita , Moghadam Nastaran Asghari , Faraji Nima , Derakhshan-Nezhad Elahe , Mohammadi Barzelighi Hajar 
Published: January 2023

AbstractInfections caused by multidrug resistant (MDR) Pseudomonas aeruginosa isolates in burn patients restrict therapeutic strategies. The current study aimed to analyze antibiotic resistance genes and multilocus sequence typing (MLST) of P. aeruginosa strains isolated from burn patients in Shahid Motahari hospital in Tehran, Iran.Altogether 63 P. aeruginosa isolates were characterized in this study. Antibiotic susceptibility testing was performed by disc diffusion method. PCR was performed to determine the frequency of resistance genes. The expression rates of mexB, mexY genes were evaluated by Real-Time PCR. Genotyping of isolates was performed by MLST analysis. All isolates were MDR in this study. The highest resistance was detected against gentamicin, tobramycin, and cefoxitin (100%), while all isolates were susceptible to colistin. Altogether 14 resistance profiles were determined, and profile 1 included more than 50% of the isolates with the highest resistance. In this study blaampC, blaVIM-2, blaOXA-10, and aac(6′)-Ib resistance genes were detected in all isolates. The expression levels of mexB and mexY genes were upregulated in 66.6 and 88.8% of MDR isolates, respectively. Overexpression of both genes was detected in 55.5% of the isolates.MLST analysis revealed five sequence types (STs), including ST235, ST664, ST532, ST2637, and ST230, which showed a significant relationship with antibiotic resistance profiles. The present study indicates an increase in antibiotic resistance against different antibiotic families among P. aeruginosa isolates. We describe the circulation of globally distributed STs among hospitalized patients, and we report ST235 as the most common MDR clone in our study.
Sociocultural determinants of alcohol and cannabis use and misuse among Nunavimmiut
Authors: Courtemanche Yohann , Poliakova Natalia , Riva Mylene , Fletcher Christopher , Desrochers-Couture Mireille , Moisan Caroline , Pépin Camille , Fraser Sarah , Muckle Gina , Bélanger Richard E. 
Published: January 2023

Abstract
Objective
Stemming from historical traumas and changes in the Inuit way of life, substance use and its intertwined problems are a major cause of concern for Nunavimmiut. This study’s objective is to investigate sociocultural determinants of substance use and misuse to inform culturally appropriate public health programs.

Methods
The 2017 Qanuilirpitaa? survey was conducted among a sample intended to be representative of Nunavimmiut aged 16 and over (total n = 1326). Sociocultural factors included cultural identity, land-based activities, involvement in community activities, social support, and family and community cohesion. The frequency of binge drinking (5 or more drinks on one occasion), cannabis use, and problematic substance use (CAGE and DAST-10) were documented. Data were analyzed using weighted multivariate logistic regressions. Inuit partners were involved from the planning of analyses to the co-interpretation of results.

Results
Nearly a third of Nunavimmiut aged 16 and over reported binge drinking at least once a week (29.3%), and 68.6% of drinkers were at risk of potential drinking problems. Forty-five percent (45%) reported using cannabis at least once a week, and 30% of drug users were at risk of potential drug abuse problems. Volunteering and participation in community activities were associated with lower odds of cannabis use, as was frequently going on the land with weekly binge drinking, potential drinking problems, and weekly cannabis use. Social support and community cohesion were associated with higher odds of weekly binge drinking, as was cultural identity (centrality scale) with potential drinking problems.

Conclusion
Key determinants of substance use relevant to Inuit culture were identified. Results are in line with our Inuit partners’ experience in their communities and are coherent with current land-based interventions implemented in Nunavik. A thorough understanding of substance use contexts and related stressors should guide the content and implementation of substance use programs in Nunavik.
Socio-economic modeling of the effect of smokers’ transition to smokeless technologies
Authors: Koryagina N. A. , Zhigulev A. N. , Zabotina A. N. , Dreval R. O. , Muravyeva K. Y. 
Published: January 2023

Research objective: Quantitative estimation of social-demographic and social-economic impact of the switch of traditional cigarettes smoking to modified risk tobacco products consumption, based on effect upon smoking-related mortality and diseases rates.Methods. Target group – consumers of smoking tobacco: conventional cigarettes (CC) and modified risk tobacco products (MRTP). Base of calculations – analysis of available time series for: CC and MRTP consumption, life expectancy and healthy life expectancy coefficients, statistics on smoking-related mortality and diseases rates, including data on key nosologies (malignant neoplasms of respiratory system, digestive organs, urinary tract; chronic obstructive pulmonary disease; circulatory diseases; cerebrovascular diseases.Results. We implemented prognoses for all the above mentioned parameters to year 2035, calculated direct medical and indirect costs for demographic and economic loss with attention to budget impact analysis, developed five scenarios based on different CC and MRTP consumption.The model of switching from CC to MRTP consumption proves a significant decline of demographic and economic burden even with rather modest MRTP replacement for CC. With current practices of switching from CC to MRTP remaining, during 2021–2035 summary impact would result in 3.6 mln of years saved, 7.7 mln of healthy years saved, 120 thous. of mortal cases and 345 thous. diseases cases prevented. The economic burden would be 3.3 trillion rubles lower.Conclusion. Smoking cessation is the optimal method to reduce health risks, and state policy for stimulation of smoking quitting is necessary. Along with that, transition from CC to MRTP may be an alternative way to reduce health risks for those smokers with long smoking history and either psychological or physiological causes who cannot quit smoking.Even small in the terms of percent transition from CC to MRTP may result in significant decrease of demographic and economic burden on the national scale.
Ethnicity as a factor in the subjective experience of loneliness in students
Authors: Zabrodin Yu. M. , Soldatova E. L. , Andronnikova O. O. , Perevozkina Yu. M. 
Published: January 2023

Introduction. The phenomenon of loneliness is multidimensional and ambigu­ous. Attitudes to loneliness are heterogeneous and mediated, among many factors, by cultural and ethnic features. Territorial proximity and historically conditioned relations and migrations of Ural-Siberian territories and Kazakhstan allow conducting intercultural and interethnic re­search. This research is devoted to the study of specifics of loneliness experience by first-year students – representatives of these nations. The problem of loneliness becomes especially ur­gent as a result of growth of anxious and depressive states, and sometimes suicidal and victim behaviour among first-year students.Aim. The aim of the current research is to identify ethnic aspects of the subjective ex­perience of loneliness of first-year students studying in Russia and Kazakhstan. The research examines the specifics of experiencing loneliness by students of different ethnic backgrounds (Russians, Kazakhs), 197 students (119 males and 78 females).Research design. The research design involved the determination of loneliness factors for the entire empirical sample (factor analysis) with subsequent calculation of the values of the received factors for each respondent. Then students were compared separately for boys and girls of Kazakh and Russian ethnicity.Measurements. To conduct the research, the authors used a set of methods to study loneliness, Zung Self-Rating Depression Scale and a questionnaire to identify the level and na­ture of loneliness by G. R. Shagivaleeva.Results. The authors found that the component composition of loneliness can be repre­sented by three factors: depressive experience of loneliness, positive experience of loneliness, experience of loneliness in interpersonal relationships. It was revealed that students of Kazakh ethnicity expressed a negative perception of loneliness (p = 0.007), actualising depressive ten­dencies. A positive experience of loneliness is more characteristic of girls than boys (p = 0.02). For girls of Kazakh ethnicity, separation from the parental family enhances the feeling of lone­liness (p < 0.05).Scientific novelty. The presented research results confirm the multidimensional nature of the phenomenon of loneliness, which determines the ambiguity of attitudes towards it and gives special weight to the value attitude towards loneliness in culture. Differences in the expe­rience of loneliness by students, due to the specifics of ethnic attitudes, are revealed. Theoretical significance of the study is determined by the identified regularities in the component composition of the experience of loneliness by students of two ethnic groups (Rus­sians and Kazakhs), its content and gender-role specificity.Practical significance. Empirical data contribute to the understanding of the ethnic characteristics of students’ experiences of loneliness and can serve as the basis for the devel­opment of university programmes that enhance psychological well-being.
Features of personality trust of Russian and Indonesian students in terms of network activity
Authors: Sungurova N. L. , Akimkina Yu. E. , Adawiyah R. 
Published: January 2023

Introduction. The process of modern youth’s cybersocialisation is caused by the digitalisation and the inclusion of information and communication technologies (ICT) in daily life. Network activity is a part of students’ socialisation. The interaction of student youth in the virtual space is conditioned by personality trust, which is revealed through the categories of trust in oneself, other users and the virtual world. The personality trust of students, as a belief in the reliability of other people and the world, regulates network activity and the life of society. Trends in the formation of personality trust in traditional and virtual space have similar prerequisites.Aim. The aim of the study is to identify the features of personality trust of Russian and Indonesian students in terms of network activity.Methodology and research methods. The study was conducted on the basis of the subject-personal approach. A set of methods was used: “Assessment of trust/distrust of a person in other people” (A. B. Kupreychenko) (the authors introduced an additional construct “virtual world”); “The study of trust/distrust of the individual in the world, other people, oneself”; “Questionnaire for the problematic use of social networks”; “Assessment of involvement in the use of ICT”.Results and scientific novelty. For the first time, personality trust is considered in the context of network activity in the framework of a comparative study of Russian and Indonesian students. Indonesian students tend to display personality trust in communication by accepting participants in network activity, in choosing more authoritative sources of information and participants with a positive reputation. Students from Russia trust reliable and credible sources and network users, basing on empathy and a similar worldview. The personality trust of students in the virtual world and network users is more pronounced among Indonesians, and trust in oneself is equally important for both groups of students. The Russian student youth is characterised by a low level of trust in the information on the network, in comparison with the Indonesian youth. General trends in the problematic use of technology have been identified, such as cognitive absorption, emotion regulation, and Internet addictive behaviour. Both groups of students prefer online communication and strive for open and effective relationships in the virtual space with like-minded people, for mutual assistance and unity.Practical significance. The results of studying the personality trust of Russian and Indonesian students in terms of network activity can be used to build open and productive relationships between young representatives of the countries, to organise psychological and pedagogical support for the socio-cultural adaptation of foreign students, to develop digital educational environment of an international university.
White matter alterations in amnestic mild cognitive impairment: a tract-based spatial statistics study
Authors: ÇAVUŞOĞLU Berrin , ADA Emel , EMEK SAVAŞ Derya Durusu , YENER Görsev 
Published: January 2023

Purpose: To compare white matter (WM) structural alterations between the subjects with amnestic mild cognitive impairment (MCI) which is a transitional state to Alzheimer's Disease (AD) and healthy elderly controls.
Methods: Diffusion tensor imaging (DTI) scans of 20 subjects with amnestic MCI and 20 healthy control groups who are matched by age, gender, and education with the MCI group between 2011 and 2016 were examined by in this retrospective study. WM structural integrity was analyzed using tract based spatial statistics (TBSS) for voxel-based differences in fractional anisotropy (FA) between the two groups.
Results: Fractional anisotropy was found significantly lower in the forceps minor, the body and genu of the corpus callosum, the right anterior thalamic radiation, the right cingulum, the right inferior fronto-occipital fasciculus, the right superior longitudinal fasciculus, and the right superior corona radiata in the MCI group than the control group.
Conclusion: TBSS analysis is a promising method to examine structural WM integrity. These findings suggested that the DTI measurements may be useful for the detection of preclinical changes in AD.
Paraservikal Blok Altında Yapılan Düşük Basınçlı Endometrial Biyopsilerde Başarısızlık Nedenlerinin Araştırılması
Authors: ARI Sabahattin Anıl , ŞENKAYA Ayşe Rabia , KARACA İbrahim , ÖZTEKİN Deniz 
Published: January 2023

Amaç
Ofis şartlarında uygulanması sebebi ile popüler hale gelen pipelle endometrial biyopsi sonrası histopatolojik tanı için yeterli materyal elde edilememesi tekniğin olumsuz yönü olarak öne çıkmaktadır. Çalışmanın amacı pipelle biyopsi başarısızlığının nedenlerini ortaya koymak olarak belirlenmiştir.
Gereç ve Yöntem
İzmir Bakırçay Üniversitesi Kadın Hastalıkları ve Doğum Anabilim Dalı’nda 2019-2022 yılları arasında pipelle biopsi işlemi uygulanan olgular planlanan retrospektif çalışmaya dahil edilmiştir. Belirlenen olguların yaş, boy, kilo, vücut kitle endeksi, gebelik ve doğum sayıları ile doğum tipleri, işlemin tıbbi gerekçesi, işlem öncesi endometrial duvar kalınlıkları, ek hastalıkları, biyopsi başarısızlık nedenleri kaydedilmiştir.
Bulgular
Çalışmaya 317 hasta alınmıştır. Olguların median yaşı 45 (min: 35 maks:88) olarak saptanmıştır. Ortalama VKI 25,06 (±3,7) olarak bulunmuştur. Materyal alınabilen 315 hastanın 266’sına (%84,4) histopatolojik tanı konulmuştur. 49 (%15,6) hastaya materyal yetersizliği nedeni ile histopatolojik tanı konulamamıştır. Tek değişkenli lojistik regresyon analizinde ileri yaş (OR 0,83, %95 CI 0,79-0,88, p=0,001), PMVK endikasyonu (OR 20,8, %95 CI 10-43,4, p=0,001), endometrial kalınlığın
Diagnosing Soft Skills in Primary School Students within the Context of the New Ukrainian School Reform
Authors: Linnik Olena 
Published: January 2023

The paper presents findings of the study conducted on soft skills (transversal skills) in Ukrainian primary school students. The study sample encompasses students representing 150 schools of various types, including experimental schools involved in piloting of the new State Standard of Primary Education. Six students were randomly selected among third graders (aged 8-9) from each school. The study employed such methods as case study, observation, content analysis and survey. Their combination allowed for a comprehensive investigation of primary school students’ soft skills.
The findings have shown that students’ best-developed skills are those belonging to personal and social domains, namely collaboration and copying with emotions. The weakest skills are related to cognitive domain and include critical and systemic thinking, reading comprehension, ability to logically argue for one’s position. Students in pilot schools have revealed certain advantage over other students in such skills as ability to articulate thoughts orally and in writing, creativity, initiative, collaboration, and problem-solving.
The study of the formation of cross-cutting skills of students was carried out using the case method, observation method, content analysis and questionnaires.
To determine the level of formation of each end-to-end skill, a methodology was developed, which was based on taking into account the results of the group's performance of both tasks (cognitive and creative) and expert observations of the implementation process.
Pull in Analysis of Nano sized RF switches using Artificial Neural Networks
Authors: Sethuraman Seetharaman , Chaitanya Pranav , S kanthamani , Percy J.Joslin , Roomi S.Mohamed Mansoor 
Published: January 2023

Abstract
An Artificial Neural Network (ANN) model for the pull-down voltage analysis of Radio Frequency (RF) NEMS (Nano Electro-Mechanical) switch is presented in this paper. The fixed-fixed beam and cantilever beam structure have been chosen and analyzed in terms of pull-down voltage with the variation of its physical parameter values. An ANN model was trained with several training algorithms to achieve higher performance and computational efficiency. The pull-down voltage predicted from the Levenberg-Marquardt backpropagation ANN model has been compared with previous results presented in experimental and theoretical studies available in the literature. The proposed ANN model was also used to investigate the geometric and physical influence of the nano-switch on the pull-in voltage, and results were reported. The proposed ANN model performs better, with less Mean Square Error (MSE) of 0.000045 and 0.000092 for cantilever and fixed-fixed beam structures respectively.