bluuebunny/crossref_metadata_2025_split huggingface dataset:
WITHDRAWN: Feasibility of using Gag proteins to reawaken dormant HIV infection based on bioinformatics analysis
Authors: Chen S. 
Published: July 2023

Abstract

The technique of using drugs to target latent virus reservoirs has been introduced to reawaken dormant viruses such that the immune system can attack them, but further tests have shown this method fails. In this study, the author attempted to analyze whether drugs can be used to reawaken dormant virus reservoirs and proposed the use of viral proteins to activate the sleeping virus. The results show that the amino acid sequence ARG of Gag proteins of HTLV-1, HTLV-2, STLV-1 and STLV-2 match their primer binding site GGGGGCTCG in the 3'-to-5' direction and that the amino acid sequence SPR of Gag proteins of HIV-1, HIV-2, SIV and FIV match their primer binding site GGCGCCCGA in the 3'-to-5' direction. The author hence believes that the latency-reversing drugs are involved in the process of the transcription of cancer genes, and because the virus genome they reawaken contains the same NF-κB binding sites, the drugs indirectly reawaken dormant retrovirus infection. Related studies showed that the genomic Gag/Gag-Pol complex recruits the LysRS/tRNA complex, the selective packaging of the tRNA primer requires HIV-1 Gag and Gag-Pol, and an interaction between LysRS and Gag is observed in vitro. In contrast, Gag proteins can more reliably be used to directly reawaken dormant HIV infection, which recruits human uncharged tRNA to serve as the reverse transcription primer.
Knowledge, Attitudes and Acceptance towards COVID-19 Vaccination among Health Care Workers in Mukalla city-YEMEN: an analytical cross-sectional study
Authors: Bnqadeem Aseel , Alsabban Mohammed , Bokir Khulod , Al-Ghazali Ruqaiah , Gaber Sarah Bin Ali , Balfaqih Sumaia , Marei Fatima Bin , Al-Amodi Fatima , Atash Sumaia 
Published: July 2023

Abstract
Background
COVID-19 vaccination is one of the greatest public health interventions to reduce the burden of the COVID-19 pandemic. Yemen began on April 2021 to vaccinate healthcare workers for COVID-19 with the vaccine. However, the media's negative portrayal of vaccines safety and efficacy has led to concerns regarding the acceptance of the vaccine. Therefore, our study aimed to assess knowledge, attitudes and acceptance towards COVID-19 Vaccination among HCWs in Mukalla city-Yemen.
Methods
An analytical cross-sectional study was conducted using convenience sampling method in Mukalla city among healthcare workers from October 2022 to December 2022. Data were collected by a self-administered questionnaire. A Chi-square test was used to assess the association between independent variables (demographic) and dependent variables (knowledge, attitude and acceptance). Correlation between knowledge and attitude levels with rate of acceptance was assessed using Pearson correlation coefficient.
Results
449 respondents were included in the final analysis, of which 237 (52.8%) were males and 212 (47.2%) were females, with a mean age ± SD of 31.0 ± 7.6 years. The overall results regarding knowledge, attitude, and acceptance rates of the COVID-19 vaccines were 65.3% 63.7% and 68.8% (with an efficacy of 90%), respectively. Acceptance was statistically associated with participants’ job, vaccination state, whether they were dealing with suspected cases of COVID-19 and their source of COVID-19 related information (p-value < 0.05). level of acceptance was moderately correlated with attitude level (r = 0.527).
Conclusion
Healthcare workers were found to have a moderate level of knowledge and attitude toward COVID-19 vaccination. However, acceptance rate was scaling down according to vaccine efficacy. Many demographic characteristics were significantly associated with acceptance of COVID-19 vaccination.
Low Computational Complexity Precoding Selection for 5G New Radio
Authors: Li Chi-Min , Huang Hsin-Jou , Wang Pao-Jen 
Published: July 2023

Abstract

In the fifth generation (5G) new radio (NR) wireless communication system, using Multiple Input Multiple Output (MIMO) system for signal transmission and reception of the millimeter wave frequency band can effectively improve the data rate performance and the received signal quality. Besides, precoding is an important method of beamforming in MIMO transmission. With the properly selected precoding matrices, transmitter and receiver can adjust the transmitting and receiving behaviors in accordance with the changes of the current channel state to reduce the interferences between users and increase the received signal strength. In this paper, a low complexity precoding selection method is proposed based on the steering angle characteristics of the precoding matrices of 5G NR. Besides, we used the software defined radio to implement the precoding selection following the requirement of the specifications of 5G. With this implementation, both transmitter and receiver can determine the suitable precoding matrices according to different precoding selection methods. Results showed that with a little error vector magnitude performance degradation, the proposed precoding selection method can reduce at least 50% of the required computational complexity of the full search method.
A new stay cable dynamic analysis method based on separation of exponential term with free vibration time history
Authors: Gao Huicai , Shi Hongyu , Luo Shuai , Hu Yunjin 
Published: July 2023

Abstract
With the continuous increase of the span of the cable-stayed bridge, the length of the stay cable also increases. Then the vibration of the becomes more complicated. It is necessary to use dynamic model for stay cable analysis and vibration control. This paper proposes a new precision dynamic model of stay cable via theoretical derivation and experimental study. According to the FEM model of stay cable with n degrees of freedom is in the following form, Quadratic transformation was used to explore the element stiffness matrix and mass matrix of stay cable based on energy theorem. Based on separation exponential term method, a new identification method for modal damping ratio of stay cable was established with the free vibration time history signals. The effectiveness and accuracy of the proposed dynamic model are numerically verified by using a stay bridge cable. The results show that the modal damping ratio error are less than 6% and the model built and the accuracy of the dynamic response analysis model of stay cable established by this method is very high.
GGDP Calculation and Application based on Shadow Prices
Authors: Zou Bin , Song Yiliang , An Hongjun , Li Youlin 
Published: July 2023

Abstract
As global climate and environmental issues continue to increase, Green Gross Domestic Product (GGDP) has become a more suitable indicator of economic health and development than Gross Domestic Product (GDP). This paper proposes a new climate-environment cost-based GGDP model in macro form, using shadow price that is more economically sound than existing GGDP models. We also introduce a new method called relation chain analysis to export the GGDP model to micro form. Our mathematical analysis predicts a positive impact of using our model on the global economy and climate.
Combined osteotomy of Luschka joint and posterior edge of vertebral body for the treatment of severe cervical spondylosis with intervertebral stenosis or osteophyte hyperplasia: a randomized trial
Authors: Yu Qiuyu , Ma Jun , Guo Zhongyi , Han Yaozheng , Su Lintao , Lei Changyu , Kang Hui 
Published: July 2023

Abstract
Background: Although ACDF is widely used in the treatment of cervical degenerative diseases, it cannot achieve adequate decompression for patients with severe intervertebral space stenosis or osteophyte hyperplasia. This study reports a modified technique of ACDF called anterior intervertebral osteotomy and fusion (AIOF) for the treatment of patients with this type of cervical spondylosis and compares its therapeutic effects with those of ACDF.
Methods: A total of 121 patients with symptomatic cervical spondylosis who had failed to respond to conservative treatment at least for 3 months were included in the study. The patients were divided into two groups and treated with AIOF and ACDF, respectively. The effects of surgical treatment were analyzed by JOA score, VAS score, spinal canal area, spinal cord diameter and Cervical lordosis.
Result: 54 patients (44.6%) were included in the AIOF group and 67 patients (55.4%) were included in the ACDF group. AIOF group and ACDF group showed no significant differences in age, sex, follow-up period, blood loss. However, the long-term prognosis of patients in AIOF group was significantly better than that in ACDF group in terms of JOA score, VAS score, spinal canal area, diameter of spinal cord and cervical lordosis (p＜0.05).
Conclusion: The osteotomy of the Luschka joint and posterior edge of the vertebral body in AIOF can achieve the decompression of nerve roots and spinal cord safely and effectively. It is a better choice than ACDF for patients with severe intervertebral space stenosis and osteophyte hyperplasia.
Regional differences in Cloud characteristics at different depth, intensity and horizontal scale over South Asia during Indian summer Monsoon using CloudSat and reanalysis data
Authors: Kumar shailendra 
Published: July 2023

Abstract

CloudSat CPR is a mm wavelength (W-band) radar and suitable for measuring the cloud sized hydrometeors. It provides the two-dimensional attenuated correct radar reflectivity factor (Ze) and cloud mask value. We used these data to explore the cloud characteristics e.g., their vertical structure, top height at different Ze thresholds, total cloud width, intensity and horizontal span over South Asian regions during the Indian summer monsoon seasons (June-July-August and September) for the years between 2006 to 2018. We defined four types of the cloud systems based on Ze and height thresholds namely deep convective core (DCC), deep & intense convective systems (DCSs & ICSs), and cloud clusters (CCs). The characteristics of cloud systems depend the thresholds used in the present study. DCCs are the individual CPR vertical profiles, whose tops are crossing 12 Km altitude, with base height less than 3 Km. CCs are the continuous area of Ze (>-28 dBZ) with no constraint on their base and top height and Ze. DCSs are defined with a minimum cloud base height (CBH < 2 km) and maximum cloud top height (CTH > 8 Km), whereas ICSs consist of maximum Ze > 10 dBZ in the continuous area of Ze. The locations of the cloud systems vary based on their vertical depth, size and intensity. The major fraction of CCs is concentrated along the north-East part, Himalayan foothills and Indian west coast but DCCs are mostly observed at head of Bay, Bay of Bengal, Eastern Himalaya Foothills and Gulf of Thailand. However, DCSs are concentrated at the land dominated and topographic areas and are observed at the Myanmar, land area of north east, Himalayan Foothills, central India and Western Ghats. ICSs are concentrated along the Himalayan foothills and Western Ghats. ICSs have less horizontal span and CTH compared to DCSs, and reveals that in intense precipitation the rainfall is falling down at early stage which do not allow them grow more horizontally and vertically. It is very rare that cloud systems could be large as well as intense over the Western side/coast of India compared to eastern side/coast of India, where cloud systems could be intense as well large also. DCSs show that east-west differences in horizontal span not in CTH, whereas ICCs show the major difference in CTH, not in horizontal span of cloud systems. The oceanic cloud tops are characterized by the cloud sized particles, whereas land and orographic cloud tops are dominated by the precipitation-size particles. CCs at high latitudes do not develop much horizontally but, but they could be deeper and intense one. CCs over the oceanic areas are more horizontally developed, but with less CTH and intensity compared to land and orographic areas whereas CCs have less horizontal span but they are intense and deeper one.
Collision risk analysis of mega constellations in low Earth orbit
Authors: Ruan Yongjing , Hu Min , Yun Chaoming , Xue Wen , Huang Gang , Gao Zefu 
Published: July 2023

Abstract
The LEO megaconstellations have thousands of satellites, which operate on similar orbital heights. Because of increasing space debris, the satellites accelerate the growth of the number of space objects, increase the threat to their own safety and sustainable utilization of the space environment. This paper focuses on short-term collision probability and long-term collision probability calculation model for collision risk of mega constellations. On the one hand, aiming at how to solve the problem quickly and accurately for rendezvous collisions, a short-term collision risk evolution calculation model of LEO mega-constellation is established. By investigating the space collision target screening methods of large-scale satellites against large-scale space debris, including apogee–perigee filtering, time window filtering, space discrete volume element filtering and relative position filtering, the filtered target trajectory is fitted by Lagrange interpolation method to obtain the motion state at the closest time. Then, the collision probability calculation method of Laplace transform is used to calculate the collision probability of the target at the closest time. On the other hand, the long-term collision risk evolution model of LEO Mega constellation is established. By simplifying the model of debris and collision, we explore the calculation method of space object density, space debris attenuation model, space target disintegration model and the distribution of disintegration targets are studied. According to the way of space debris’ generation and extinction to calculate the change of space density. The collision probability between the satellite and space debris and space debris are calculated by using the calculation method of collision probability of particle-in-a-box (PIB). Finally, through the simulation of Starlink phase I constellation, results show that after the deployment of the Starlink constellation, the probability of a short-term collision in the constellation shell increases by 30–40%, the probability of at least one collision in the constellation lifetime is 70.2%, and the probability of a secondary collision increases by 25.3% after a collision. This study provides a theoretical reference for analyzing the orbital safety of the LEO mega-constellation, and provides a reference for the safe operation of spacecraft on-orbit and the sustainable development and utilization of space resources.
The potential for physical activity to alleviate hallucinations among adults with Charles Bonnet Syndrome
Authors: Hollis Jarrod , Bharwani Aliyah , Lindsay Rosie , Beukes Eldre , Smith Lee , Allen Peter 
Published: July 2023

Abstract

Charles Bonnet Syndrome is a condition in which people with vision impairment experience visual hallucinations. Although the syndrome is not well understood, recent research has suggested that physical activity may play a role in its management. A pilot survey investigated the relationship between physical activity, sleep and hallucinations in 29 individuals with Charles Bonnet Syndrome. Fifty-five percent of the respondents reported that they did not notice whether physical activity made any difference to the frequency and/or duration of their hallucinations. Nevertheless, provisional analysis suggested that people who attained the World Health Organisation’s recommended levels of physical activity reported fewer hallucinations. Reinforcing that physical activity may be useful to patients with Charles Bonnet Syndrome as a strategy for reducing their experiences of hallucinations. Further research is needed to explore the underlying mechanisms of these relationships and to determine the optimal levels and types of physical activity for managing symptoms in each individual.
Salicylic acid-induced impact on fluorescence kinetics, antioxidant properties, and growth of Amaranthus plant.
Authors: Kumar Arun , Yadav Pradeep Kumar , Singh Anita 
Published: July 2023

Abstract
Plants are unable to grow at their full potential under different environmental stress conditions which could lead to decreased crop productivity. To improve the growth of the plants in such situations, application of fertilizers and agrochemicals are employed by the farmers. However, the application of phytohormones is still under exploration. In this context, in the present study, salicylic acid with different doses (5 µM, 10 µM, 20 µM, 50 µM, and 100 µM) have been used for the foliar application at four days intervals three times to grow Amaranthus plants in pot soil under natural weather conditions. Among all the treated plants it was observed that among all the doses, at 10µM SA there was the maximum increase in the total plant length, leaf number, and fresh biomass by 23%, 16%, and 34%, respectively. The values of the chlorophyll fluorescence matrix also showed a beneficial impact of salicylic acid only up to 20 µM of SA. Further, the level of oxidative biomarkers including SOR and MDA reduced up to 20 µM of SA but H2O2 showed an increasing trend in a dose-dependent manner. To counterbalance the oxidative biomarkers, the application of salicylic acid increased the activities of SOD, POD, APX, and elemental uptake (Ca, Mg, Zn) concentration-wise. However, among the different antioxidative enzymes, CAT showed a different trend by decreasing their activities with increasing doses of salicylic acid. Exogenous salicylic acid also reduced the level of oxalic acid and increased the level of endogenous salicylic acid. Therefore, among the different doses, the lower dose particularly the 10 µM showed a better biomass allocation and qualitative attributes over the control plants. This study would provide a sustainable strategy where the appropriate dose of salicylic acid could be applied to support the plant metabolism in the presence of any stress conditions.
Reasons for Underutilization of Community Care Facilities for the Elderly in China
Authors: Zhang Hengyuan , Zhang Sifeng 
Published: July 2023

Abstract

Background
China’s government has invested a great deal of resources to improve the coverage rate of community care facilities for the elderly. However, the facilities that have been built are underutilized.
Methods
Referring to the Anderson model, a framework for analyzing the utilization of community care facilities for the elderly was constructed. Descriptive statistics on survey data from 17 communities demonstrated the status of the utilization, and binary logistic regression analysis examined the influencing factors of the utilization.
Results
Built community care facilities for the elderly are underutilized and there are significant differences in the influencing factors of the utilization between daily care facilities, medical care facilities, recreation facilities, and spiritual comfort facilities.
Conclusions
The main reasons for the underutilization are as follows: (1) the construction of facilities did not meet the diverse needs of the elderly; (2) insufficient enabling resources constrained the demand for facilities; (3) there was a mismatch between facilities' supply structure and demand structure; (4) the community care facilities are highly substitutable; (5) the pressure of bureaucracy restricts the development of facilities. To address the underutilization of community care facilities, it is recommended to clarify the community responsibility boundaries for elderly care and the role that the market plays in community care facilities for the elderly.
Extracorporeal circulation through peripheral vascular successful rescue Abdominal Aortic Iatrogenic Injury During Total en bloc Spondylectomy for L4 Ewing’s sarcoma: A Case Report
Authors: Qiao Xiaochen , Tian Zhi , Li Xiaoyan , Bai Junjun , Lv Jia , Zhang Kun , Yan Lei , Guo Guangwei , Qin Wenyan , Yan Sheng , Shen Sugang , Li Qiang , Lv Zhi , Feng Yi 
Published: July 2023

Abstract
Introduction:
Abdominal aortic iatrogenic injury can result in massive hemorrhage and is a potentially fatal complication of total en-bloc spondylectomy surgery (TES) for primary malignant spinal tumors (PMST). Currently, there is no definite management for this complication. We report a case of a patient with abdominal aorta iatrogenic injury at the intervertebral disc of lumbar 3 (L3) to lumbar 4 (L4) level during TES performed via a posterior approach. Fortunately, our patient had a good outcome with prompt intervention.
Patient concerns:
A 16-year-old male was admitted to our department with a chief complaint of low lumbar pain, especially pain at night, since the past 6 months.
Diagnosis:
PMST at L4 (Ewing's sarcoma) with abdominal aorta iatrogenic injury at the L3 − L4 level that occurred during TES that was performed via a posterior approach.
Interventions and outcomes:
Multi-disciplinary treatment (MDT), including extracorporeal circulation (ECC) through the peripheral vasculature, was immediately performed to allow for the suturing of the abdominal aortic injury. After the abdominal aorta iatrogenic injury repair, the patient’s hemodynamic parameters stabilized. Two weeks later, TES was reattempted and successfully performed for L4 PMST.
Conclusion
Intraoperative vascular injury during posterior TES is rare; however, it cannot be avoided with surety since the anterior vertebral manipulation during TES is performed blindly. This complication is often lethal and not diagnosed. Consequently, surgeons must have a wide knowledge of the lumbar spine anatomy and its surrounding structures and conduct a detailed preoperative radiological assessment of the tumor and its surrounding structure. Furthermore, the surgeon should be aware of the risk of vascular injury and familiar with its clinical characteristics for prompt and effective diagnosis and intervention once an injury is suspected to avoid serious consequences. For abdominal aortic injury, the immediate establishment of ECC through peripheral vasculature to suture the vascular laceration may be a quick, safe, and effective management.