bluuebunny/crossref_metadata_2025_split huggingface dataset:
Aplastic anemia in a patient with papillary thyroid carcinoma complicated with Hashimoto’s thyroiditis: a case report
Authors: Wu Fei , Xiao Yiwei , Hai Rui , Chen Xiaodong , Liu Shanshan , Zhou Xiangyu 
Published: January 2025

BackgroundIt is uncommon to come across instances of aplastic anemia in individuals suffering from papillary thyroid carcinoma complicated by Hashimoto’s thyroiditis. Here, a unique case is presented.Case presentationA 23-year-old male was admitted to the hospital for “a lump in his right neck”. Laboratory tests revealed a decrease in white blood cells (WBC), red blood cells (RBC), and platelet count (PLT). Bone marrow aspiration revealed an extremely low degree of hyperplasia of hematopoietic cells. Simultaneously, the levels of thyroglobulin antibodies and thyroid peroxidase antibodies were significantly elevated. Neck ultrasound findings revealed nodules in both lobes of the thyroid. Moreover, fine-needle aspiration biopsy indicated the atypical presence of proliferative thyroid epithelial cells. Even after implementing various treatments hematopoietic function could not be restored. However, following a surgery, the patient’s WBC, RBC, and platelet counts gradually returned to normal.ConclusionsHere, we present a case that thyroid cancer complicated with Hashimoto’s thyroiditis may affect hematopoietic function.
The efficacy and safety of CD7 chimeric antigen receptor T-cell therapy for hematologic malignancies: a systematic review and meta-analysis
Authors: Liu Jile , An Yuxin , Sun Rui , Zhang Xiaomei , Guo Shujing , Gao Xuejin , Zhao Mingfeng 
Published: January 2025

IntroductionCD7 chimeric antigen receptor T-cell (CAR-T cell) therapy is an emerging method for treating hematological malignancies, and is another breakthrough in CAR-T cell therapy.MethodsThis study summarizes the currently published clinical research results on CD7 CAR-T cells and evaluates the safety and effectiveness of CD7 CAR-T cell therapy.ResultsAmong the 13 studies included in this study, a total of 200 patients received CD7 CAR-T cell therapy, including 88 patients who received autologous CAR-T cells, 112 patients who received donor derived CAR-T cells. 87% (80% -94%, I2=29.65%) of patients achieved complete remission. The incidence of cytokine release syndrome (CRS) was 94% (88% -98%, I2 =32.71%, p=0.12), while the incidence of severe CRS (grade ≥ 3) was 12% (5% -20%, I2=41.04%, p=0.06). As for the incidence of immune effector cell-associated neurotoxicity syndrome (ICANS), it is 4% (1% -7%, I2=0, p=0.72). Through analysis of the key clinical issues, we found that consolidation allogeneic hematopoietic stem cell transplantation (allo-HSCT) after CAR-T cell therapy can significantly improve survival and avoid recurrence. Therefore, we believe that the consolidation allo-HSCT after CD7 CAR-T cell therapy should be advocated. And patients who received CD7 CAR-T cell therapy without gene editing had significantly longer overall survival than those who received CD7 CAR-T cell therapy with gene editing. This suggests that gene edited CD7 CAR-T cells may pose some potential risks that limit the long-term survival of patients.ConclusionOur study confirms the efficacy and safety of CD7 CAR-T cells and provides research directions for the subsequent treatment.Systematic Review Registrationhttps://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=502896, identifier CRD42024502896.
Computed tomography-based investigation of degenerative neural cervicothoracic foraminal stenosis as a potential mechanism for Horner syndrome
Authors: Ong Joshua , Kurokawa Mariko , Khanna Sangeeta , De Lott Lindsey B. , Kurokawa Ryo , Sharma Aseem 
Published: January 2025

PurposeTo investigate the presence and/or severity of cervicothoracic foraminal stenosis between the C7 and T3 segments could account for Horner syndrome, otherwise deemed to be idiopathic in nature.MethodsThis study was an IRB-approved, retrospective study that included 28 patients [mean ± standard deviation (age: 54.5 ± 18.7 years)] with a confirmed diagnosis of Horner syndrome, absence of any identifiable cause, and availability of a neck CT/CT angiogram obtained within 6 months of the diagnosis. A neuroradiologist masked to the laterality of Horner syndrome reviewed the CT scans, documenting the presence/severity of foraminal stenosis at levels C7-T1, T1-2, and T2-3 on a 4-point Likert scale defined as follows: 0, none; 1, mild; 2, moderate; and 3, severe narrowing, with grades 1, 2, and 3 signifying &lt;1/3rd, 1/3rd–2/3rd, and &gt;2/3rd stenosis of the expected normal foraminal dimension.ResultsForaminal stenosis was present ipsilateral to the side of Horner syndrome in four (14.3%) patients and on the contralateral side in five (17.8%) patients. No significant difference in the extent of ipsilateral and contralateral foraminal stenosis was present at C7-T1 (p = 0.66), T1-2 (p = 0.32), or T2-3 (p = 0.75) levels. Mean ipsilateral (0.33 ± 1.0) and contralateral (0.33 ± 1.1) cumulative foraminal stenosis ddddscores were not significantly different (p = 1). Mean maximum foraminal stenosis scores ipsilateral (0.22 ± 0.59) and contralateral (0.30 ± 0.81) to the side of Horner syndrome were also comparable (p = 0.54).ConclusionWith the low prevalence of foraminal stenosis at C7-T3 segments and the equivalent prevalence and severity of foraminal stenosis ipsilateral and contralateral to the side of Horner syndrome, foraminal stenosis is unlikely to be a common causative mechanism for Horner syndrome.
Overcoming virtual distance: a systematic review of leadership competencies for managing performance in telework
Authors: Bravo-Duarte Felipe , Tordera Núria , Rodríguez Isabel 
Published: January 2025

IntroductionLeadership in organizations is facing important challenges related to technological and social developments. The widespread use of teleworking and remote work requires organizations to identify and develop leadership competencies adapted to this work context. This structured literature review explores empirical evidence on theleadership competencies that facilitate telework and how they contribute to achieving high levels of performance in teleworkers.MethodsWe analyzed 22 quantitative and 15 qualitative empirical articles (2000–2024) following PRISMA guidelines. We selected only research that concentrates on specific leadership competencies.ResultsThe review shows that competencies oriented to decrease operational and social distance at work are positively related to individual and team task performance in organizations. There is some evidence of the relationship of those competencies with other dimensions of performance such as innovative performance or OCB. Leaders' digital communication emerges as the foremost competency, along with goal management, support and empowerment. To some extent, mechanisms such as trust, autonomy, and media usage have been found as intervening mechanisms. Moderators such as teleworkers' self-management and geographical distance have been identified.DiscussionSubstantial gaps in the literature were identified, including the lack of longitudinal studies, limited research on contextual/adaptive performance, and lack of attention to adapting leadership competencies to digital settings. The findings provide guidelines for leadership training and development interventions tailored to telework, considering that traditional leadership competencies may need adaptation for telework and consider specific issues in this context.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42023473498, identifier: CRD42023473498.
Pregabalin vs. gabapentin in the treatment of neuropathic pain: a comprehensive systematic review and meta-analysis of effectiveness and safety
Authors: Mayoral Víctor , Galvez Rafael , Ferrándiz Marta , Miguéns Vázquez Xoán , Cordero-García Carlos , Alcántara Montero Antonio , Pérez Concepción , Pérez-Páramo María 
Published: January 2025

IntroductionNeuropathic pain is a prevalent and burdensome condition, and both pregabalin and gabapentin are widely used for its treatment. However, there is a lack of clarity regarding their comparative efficacy and safety. This meta-analysis aims to evaluate and compare the effectiveness and safety of pregabalin vs. gabapentin in managing neuropathic pain.MethodsThis study followed PRISMA guidelines and employed the PICOS search strategy. Comparative studies (clinical trials and cohort studies) were included, with patients with neuropathic pain treated either with pregabalin or gabapentin. Primary outcomes assessed were efficacy and safety. Data were extracted from PubMed, Embase, Scopus, and the Cochrane Collaboration Library databases. The risk of bias was evaluated using the Cochrane Review Manager tool. Statistical analysis was performed using Review Manager 5.4.1 software, calculating effect sizes and conducting sensitivity analysis based on medication dosage.ResultsA total of 14 studies with 3,346 patients were analyzed. Pregabalin showed superior results compared to gabapentin in the Visual Analog Scale (VAS) at various time intervals up to 12–14 weeks (SMD −0.47, 95% CI −0.74 to −0.19). The pregabalin group also had significant improvements in SF-12/SF-36/EQ-5D scores (SMD 0.39, 95% CI 0.11–0.68) and experienced more days with no/mild pain (MD 9.00, 95% CI 8.93–9.07) and fewer days with severe pain (MD −3.00, 95% CI −4.96 to −1.04). Pregabalin resulted in lower opioid consumption (OR 0.50, 95% CI 0.33–0.76). Gabapentin had a higher incidence of nausea and vomiting. Sensitivity analysis supported the efficacy of pregabalin.ConclusionIn conclusion, pregabalin demonstrated superior and faster efficacy in alleviating neuropathic pain than gabapentin did. Additionally, it improved patient-reported outcomes, resulted in lower opioid consumption, and led to fewer adverse events.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?RecordID=565208, PROSPERO (CRD42024565208).
Cerebral tissue oxygen saturation and its potential relationship with neurodevelopmental delay in pediatric liver transplant recipients
Authors: Fan Yichen , Pan Qianling , Su Henghua , Pu Zhongchan , Zhu Linjie , Qi Bo , Su Diansan , Yang Liqun , Huang Dan , Yu Weifeng 
Published: January 2025

ObjectiveTo discover the potential association between diminished intraoperative average SctO2 levels and postoperative neurodevelopmental delays among patients after pediatric living-donor liver transplantation.Study designPatients undergoing living-donor liver transplantation were recruited for this trial. The neurodevelopment status of patients was assessed using the Ages Stages Questionnaires. The primary outcome was the occurrence of neurodevelopmental delay among patients at different intervals following pediatric liver transplantation. Secondary outcomes included the duration of mechanical ventilation, rates of re-intubation, length of ICU stay, postoperative hospitalization, and intraoperative comparisons of mean arterial pressure (MAP), arterial partial pressure of oxygen (PaO2), arterial partial pressure of carbon dioxide (PaCO2), and hemoglobin (Hb) concentration.ResultsA total of 119 patients were included in the statistical analysis and assigned to high saturation group (HS) and low saturation group (LS) according to the average intraoperative cerebral tissue oxygen saturation values. Following adjustment for PELD scores, significant differences between the two groups were observed for the incidence of neurodevelopmental delay in communication at 1 and 3 months follow-up (P = 0.019 and P = 0.020, respectively), fine motor at six months follow-up (P = 0.014), and problem-solving abilities at one year follow-up (P = 0.047). Moverover, the length of ICU stay (P = 0.009) and postoperative hospitalization (P = 0.029) in LS group were also significant prolonged.ConclusionThis prospective observational study revealed that the patients with low average SctO2 values were more predisposed to experiencing postoperative neurodevelopment delays, suggesting a potential association between decreased average SctO2 and neurodevelopmental delay.
Optic nerve sheath diameter/eyeball transverse diameter ratio by ultrasound in prediction of increased intracranial pressure in children with viral encephalitis
Authors: Zhao Chun , Sun Peng-Cheng , Fang Ke-Jie , Fu Hui-Hui , Wei Li-Feng , Miao Yin-Yun , Guo Xin-Xin , Weng Xiao-Ling 
Published: January 2025

IntroductionIncreased intracranial pressure (ICP) is common with viral encephalitis in children which is associated with complications and prognosis. The optic nerve sheath diameter (ONSD) is a new indicator for the assessment of intracranial pressure using ultrasound, CT scan and MRI imaging. Given the influence of physical development on ONSD size in children, we expect more accurate assessment of intracranial pressure with ONSD/ETD (eyeball transverse diameter) ratio by ultrasound. The aim of the study is to determine the performance of the ONSD/ETD ratio measurement to predict ICP occurring in children with viral encephalitis and evaluate the therapeutic effect.MethodsChildren with viral encephalitis from May 2022 to June 2024 were recruited in this study. The initial ONSD/ETD ratio measurement by ultrasound were completed before lumbar puncture. Children were divided into the increased ICP group and the normal ICP group based on whether the ICP was over 200 mmH2O measured by lumbar puncture. The ultrasound was repeated on the 3rd and 7th day of treatment.ResultsThe ONSD/ETD ratios measured in the two groups before treatment were 0.231 ± 0.019 and 0.182 ± 0.012, respectively (p &lt; 0.01). The ONSD/ETD ratio on the 3rd day of treatment in the increased ICP group was significantly lower than the data before treatment (p &lt; 0.01). The data on the 7th day of treatment in increased ICP group was significantly lower than the data before treatment (p &lt; 0.01), but not statistically significant compared to the data on the 3rd day of treatment (p = 0.650). The ROC curve demonstrated an AUC for ONSD/ETD ratio in predicting the occurrence of increased ICP in children with viral encephalitis was 0.974 [95% confidence interval (CI): 0.939–1.000, p &lt; 0.01], with a sensitivity of 95.1% and specificity of 93.3% at a cut-off value of 0.198.ConclusionOur study shows that ONSD/ETD can be used as an easy reference tool for evaluating ICP in children with viral encephalitis which can reflect the therapeutic effect.
Changes in blood glucose and lipid metabolism levels in children with central precocious puberty and its correlation with obesity
Authors: Cui Xin , Sun Xin , Li Qiubo , Chen Zongbo 
Published: January 2025

ObjectiveThis study analyzed the changes in blood glucose and lipid metabolism levels in children with central precocious puberty (CPP) and the correlation between CPP and obesity.MethodsIn total, 88 children with CPP aged 6–10 years who were admitted to our hospital between January 2023 and June 2024 (the CPP group), and 88 children without CPP in the same age group who received health check-ups (the non-CPP group) were retrospectively enrolled in this study. General data [gender, age, bone age, and body mass index (BMI)] were collected. Levels of blood glucose metabolism indicators [fasting plasma glucose (FPG), 2-h postprandial blood glucose (2hPG), and hemoglobin A1c (HbA1c)] and blood lipid metabolism indicators [triglyceride (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C)] were compared. The incidence of obesity was calculated, and the Tanner stages of the obese group and the non-obese group were compared. The correlation between CPP degree (measured by Tanner staging) and obesity degree (measured by BMI) was analyzed using Spearman’s correlation analysis.ResultsThe differences in gender and age between the CPP and non-CPP groups were insignificant (P &gt; 0.05). Bone age and BMI in the CPP group were higher than in the non-CPP group (P &lt; 0.05). The CPP group had higher serum FPG, 2hPG, HbA1c, TG, TC, and LDL-C levels and lower serum HDL-C levels than the non-CPP group. The incidence of obesity was higher in the CPP group (21.59%, 19/88) than in the non-CPP group (6.82%, 6/88). The Tanner staging scores in the obese group for the boys (testes and pubic hair), girls (breasts and pubic hair), and as a whole (testes/breasts and pubic hair) were elevated compared to those in the non-obese group (P &lt; 0.05). Spearman’s correlation showed that the CPP degree (measured by Tanner staging) was positively correlated with the obesity degree (measured by BMI) in boys, girls, and the study sample as a whole (P &lt; 0.001).ConclusionChildren with CPP had abnormal levels of blood glucose and lipid metabolism, and the CPP degree in these children was positively correlated with the degree of obesity.
A refined kidney tumor nephrometry system employed to screen pediatric patients who are eligible for nephron sparing surgery
Authors: Huang Mingchuan , Fei Yingchun , Zhong Zhihai , Jiang Hong , Liu Longshan , Liu Juncheng , Zhang Huanxi , Li Jun , Xu Zhe , Gao Pengfei , Wang Changxi 
Published: January 2025

PurposeComprehension of the anatomical characteristics of pediatric kidney tumors is crucial for making surgical decisions. Previous kidney tumor nephrometry systems failed to incorporate two significant factors: tumor thrombus and multifocality. We develop a refined nephrometry system based on a comprehensive understanding of the characteristics exhibited by pediatric kidney tumors.MethodsThe TUMORS nephrometry scoring system comprises 6 indicators, including tumor (T)hrombus, (U)rinary collecting system involvement, (M)ultiple tumors, (O)utward property, (R)adius, and (S)ite relative to the polar lines. Each renal unit was assessed and scored independently. The complexity characteristics of kidney tumors were summarized, and the correlation was compared with RENAL nephrometry system. Furthermore, the complexity of kidney tumors was compared across different surgical procedures.ResultsA total of 43 patients were enrolled, involving 70 kidney units. Radical nephrectomy (RN) was performed on 13 kidneys, while the remaining 57 kidneys underwent nephron sparing surgery. In the NSS group, tumors in 37 kidneys were resected in vivo, whereas 20 kidneys underwent tumor resection ex vivo followed by kidney autotransplantation. According to the TUMORS nephrometry scoring system, there were 13, 34 and 23 kidney units classified as low, moderate and high complexity, respectively. Tumors that underwent RN or ex vivo removal exhibited higher complexity. The complications and positive margins of NSS were not statistically significant in relation to tumor complexity.ConclusionThe TUMORS nephrometry scoring system holds significant guidance for the decision of surgical protocol and can be applied to the preoperative evaluation.
Risk factors for prolonged surgical duration of tracheobronchial foreign body removal in children: a single-center retrospective study
Authors: Su Zhe , Zhang Jianmin , Gao Zhengzheng , Wang Fang , Li Lijing , Xu Zenghua , Liu Heqi , Zhang Fuzhou 
Published: January 2025

ObjectThis study aims to analyze the clinical characteristics of children with tracheobronchial foreign body and to investigate the factors influencing the surgical duration of rigid bronchoscopic foreign body removal under general anesthesia.MethodsWe retrospectively identified 421 children diagnosed with tracheobronchial foreign body undergoing rigid bronchoscopy between January 2020 and December 2021. A comprehensive analysis was conducted on patient demographics, including age, weight, gender, American Society of Anesthesiologists (ASA) physical status classification, foreign body type and location, duration of foreign body retention, preoperative symptoms, signs, imaging findings, tracheobronchial manifestations observed during bronchoscopy, and surgical durations. Statistical analysis utilized both univariate and multivariate linear regression models to assess factors influencing the surgical duration of tracheobronchial foreign body removal in children.ResultsThe mean age of children with tracheobronchial foreign body was 1.59 years (1.32, 2.04). The male-to-female ratio was 1.8:1, and the ASA physical status classification was predominantly ASA II (96.7%). Organic foreign body accounted for 94.8% of cases, with 91.7% located unilaterally. Univariate and multivariate linear regression analyses revealed that ASA III, pulmonary rales, and the presence of one, two, or three specific tracheobronchial manifestations observed during bronchoscopy—including mucosal hyperemia and edema, purulent exudate, and granulation tissue—were independent risk factors associated with prolonged surgical duration for foreign body removal (P &lt; 0.05).ConclusionASA III, pulmonary rales, and various tracheobronchial manifestations observed during bronchoscopy are significant risk factors associated with prolonged surgical duration for foreign body removal in children.
Comprehensive analysis of adverse events associated with onasemnogene abeparvovec (Zolgensma) in spinal muscular atrophy patients: insights from FAERS database
Authors: Zhang Wenwen , Yin Yizhen , Yang Dan , Liu Mengyuan , Ye Caixia , Yan Ruiling , Li Ruiman 
Published: January 2025

Onasemnogene Abeparvovec (Zolgensma) is a gene therapy for the treatment of Spinal Muscular Atrophy (SMA) with improved motor neuron function and the potential for a singular treatment. Information on its adverse drug reactions is mainly from clinical trials and real-world studies with extensive sample sizes are lacking. In this study, we analyzed the U.S. Food and Drug Administration’s Adverse Event Reporting System (FAERS) database to assess the drug safety profile of Zolgensma. A total of 1951 adverse event reports associated with onasemnogene abeparvovec (Zolgensma), containing 778 import important medical event (IME) signals, were identified from the FAERS database, and multiple disproportionate analysis algorithms were used to determine the significance of these adverse events. This study identified 281 onasemnogene abeparvovec-related adverse events (AEs), including some significant adverse events not mentioned in the product labelling. Elevated liver enzymes, fever, vomiting, and thrombocytopenia were the most common adverse reactions. Most adverse events manifested within the initial month of onasemnogene abeparvovec use, especially the first 8 days, but some may still occur after 1 year of treatment. Sex-specific scrutiny revealed differing risk levels for adverse events among women and men. Thrombocytopenia and thrombotic microangiopathy are more common in patients weighing ≥8.5 kg, and changes in renal function need to be closely monitored if thrombotic microangiopathy occurs. The above findings provide valuable insights into optimizing the utilization of onasemnogene abeparvovec, improving its effectiveness, and minimizing potential side effects, thereby greatly facilitating its practical application in clinical settings.