bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of hemostatic ability between spray coagulation and forced coagulation modes in endoscopic submucosal dissection in patients with early gastric neoplasms: A study protocol for multicenter randomized controlled trial (Spray-G trial)
Authors: Maehara Kosuke , Esaki Mitsuru , Sumida Yorinobu , Yamaguchi Daisuke , Nishioka Kei , Homma Hitoshi , Inada Taisuke , Shiotsuki Kazuo , Fukuda Shin-Ichiro , Akiho Hirotada , Nomura Tadahiro , Mizuta Yumi , Ishida Satoshi , Fujimoto Shun , Kimura Shunichiro , Tanaka Yuichiro , Hata Kaori , Shiga Noriko , Iwasa Tsutomu , Kimura Yusuke , Nakamura Norimoto , Suzuki Yusuke , Minoda Yosuke , Hata Yoshitaka , Ogino Haruei , Tagawa Koshiro , Ihara Eikichi , Ogawa Yoshihiro 
Published: September 2023

Abstract
Background: Endoscopic submucosal dissection (ESD) is the standard treatment for early gastric neoplasms (EGN). Controlling intraoperative bleeding is crucial for ensuring safe and reliable procedures. ESD using the Spray Coagulation Mode (SCM-ESD) has been developed to control bleeding more effectively than ESD using the conventional Forced Coagulation mode (FCM-ESD). This study aims to compare the hemostatic efficacies of SCM-ESD and FCM-ESD.
Methods: This multicenter, prospective, parallel, randomized, open-label superiority trial will be conducted in five Japanese institutions. Patients with a preoperative diagnosis of intramucosal EGC will be randomized to undergo either SCM-ESD or FCM-ESD. The primary outcome measure is the completion of ESD with an electrosurgical knife alone, without the use of hemostatic forceps. Secondary outcomes include the number and duration of hemostasis using hemostatic forceps, procedure time, curability, and safety. A total of 130 patients will be enrolled in this study.
Discussion:This trial will provide evidence on the hemostatic efficacy of SCM-ESD compared with FCM-ESD in patients with intramucosal EGN, potentially improving the safety and reliability of ESD procedures.
Trial Registration: The trial has been registered at the University Hospital Medical Information Network Clinical Trials Registration (UMIN-CTR) as UMIN000040518.
Spatio-temporal Analysis of Albedo Changes and its relationship with climatic and physiographic factors of the earth surface in Iran
Authors: nejad meysam toulabi , sharifi leyla , dolatshahi zeynab , nejad mehrshad toulabi 
Published: September 2023

Abstract

This research aims to analyze spatial-temporal changes of albedo. Cloudiness, topography and vegetation density (NDVI) in Iran were investigated based on the parameters of soil humidity (Wetness), using MEERA2 model with a resolution of 50 x 50 km from 2010 to 2020. The results of the spatial analysis of albedo values in Iran showed that the highest values belong to western and then central regions while the lowest albedo values belong to the north and northwest regions. The highest value is 30% on average recorded at 44 to 45 ºE and the lowest reflection value is14% on average recorded between 50 to 51 ºE, i.e. the eastern slopes of the Zagros mountain range. In terms of latitude, the lowest value was at 37.5 ºN and the highest value was at 30.5 ºN showing 17 and 29 percent, respectively. In terms of provincial changes of albedo value, the highest reflection being 25.3% belongs to Ilam province, and the lowest albedo value belongs to northern provinces (Gilan and Mazandaran) being 17.5% on average. Similarly, the results of time analysis on a seasonal scale showed that the highest recorded value of surface albedo is 21.1% in the summer and the lowest is 19.8%in the spring. In the areas with small amounts of surface albedo, cloud cover, vegetation and humidity are higher, and the slope is toward the southwest; but the areas with higher values of surface albedo have less vegetation cover, cloudiness and humidity and the slope is toward the north.
Effect of preinfusion of low-dose alfentanil on the induction of anesthesia with remimazolam in gynecological day surgery: a prospective, double-blind, randomized controlled study
Authors: Lu Dong , Qin Dalong , Gao Dong , Ji Fanceng , Zhao Xiaoyong , Shan Jinghua , Sun Meiyan 
Published: September 2023

AbstractPurpose: Alfentanil has a synergistic sedative effect with benzodiazepines, and this study aimed to investigate the effect of preinfusion of low-dose alfentanil on the dose of remimazolam for loss of consciousness while observing the effect on hemodynamic changes and other adverse effects.Methods: Thirty-four gynecological day surgery patients were selected and randomly divided into the control group and the observation group; before anesthesia induction, both groups were given dexamethasone 5 mg, haloperidol 1 mg, and flurbiprofen ester 50 mg. Anesthesia induction: The control group was prefilled with 10 ml of saline, and remimazolam was pumped in rate of 6 mg/kg/h until consciousness disappeared; Micuronium chloride was injected slowly at 30 seconds, alfentanil 15 µg/kg was injected slowly at 30 seconds, and mechanical ventilation was carried out 2 minutes after placement of a laryngeal mask. In the observation group, first, 5µg/kg of alfentanil diluted to 10 ml was administered, remimazolam was pumped at rate of 6 mg/kg/h until consciousness disappeared, 0.2 mg/kg micuronium chloride was injected slowly for 30 seconds, 15 µg/kg alfentanil was injected slowly for 30 seconds, assisted ventilation was performed, a laryngeal mask was placed after 2 minutes, and mechanical ventilation was implemented. Anesthesia maintenance: remimazolam 1 mg/kg/h, alfentanil 40 µg/kg/h to maintain anesthesia, and micuronium chloride 0.05 mg/kg was given for more than 30 minutes of surgery; infusion of anesthetics was stopped at the end of surgery. The primary outcome was the dose of remimazolam for loss of consciousness; the secondary outcomes were the changes in hemodynamics during the induction period of anesthesia, and the incidence of adverse events such as hiccups and involuntary body movements during the induction period.Results:The dose of remimazolam for loss of consciousness in group A (13.14±2.51) mg was lower than that in group C (17.09±3.40) mg (p<0.05); the time to loss of consciousness in group A (123.81±21.08) s was lower than that in group C (156.80±30.67) s (p<0.05); the incidence rate of total adverse reactions in group A (12.5%) was lower than that in group C ( 46.6%); the heart rate of group A was slightly higher than that of group C (p=0.003), and there was no significant difference in MAP, SPO2 and BIS between the two groups (p>0.05).Conclusions: Preinfusion of a low dose of alfentanil significantly reduces the dose of remimazolam, causing loss of consciousness, speeds up induction, reduces the overall rate of adverse effects, and slightly increases heart rate.
Successful therapy by WBRT with concurrent intrathecal MTX for isolated leptomeningeal metastasis in ER+ HER2− breast cancer: case report
Authors: Liu Shuying , Pei Jinrui , Li Xiao , Gao Yating , Zhang Kaining , Yin Jierong , Li Xiaofei , Wang Xia , Zhang Huijuan , Zhang Dongfeng 
Published: September 2023

Abstract
Background: Leptomeningeal metastasis(LM) is a relatively rare but devastating manifestation of breast cancer, with an incidence rate of approximately 5%, half of these patients suffer from simultaneous brain metastasis. LM in breast cancer (LM-BC) carries a poor prognosis, with a median overall survival of approximately four weeks without treatment. However, there is no standardized therapy for LM yet.
Case presentation: We present a 63-year-old female with estrogen receptor (ER)-positive Her2− breast cancer after multiline treatment, her pathological examination of the cerebrospinal fluid (CSF) revealed numerous malignant cells, magnetic resonance imaging(MRI) of the brain with contrast demonstrated intense enhancement of the leptomeninges, without brain metastasis. She achieved complete intracranial remission and prolonged survival by whole-brain radiotherapy (WBRT) concomitant with intrathecal methotrexate (MTX). A literature review was included to summarize the present status of ER+ HER2− LM-BC.
Discussion and Conclusions: There are a great number of studies on the therapy of LM from HER2+ BC, but there is limited information on ER+ HER2− BC with isolated LM, which is rarer than other BC subtypes and predicts a worse prognosis. Concurrent WBRT with intrathecal MTX may improve the quality of life and prolong the survival of LM-BC, especially for ER+ HER2− ones. Our case indicated ER+ HER2− LM-BC can be effectively treated by radiotherapy with concurrent intrathecal chemotherapy (IC). To provide longer and better survival benefits for patients with ER+ HER2− LM-BC, further trials are urgently needed to explore the therapeutic order and therapeutic dose of radiotherapy and intrathecal chemotherapy.
Pseudo-Meigs’ syndrome caused by rapidly enlarging hydropic leiomyoma with elevated CA125 mimicking ovarian malignancy: A case report and literature review
Authors: Zou Longquan , Lou Jinlong , Huang Haoran , Xu Lian 
Published: September 2023

Abstract

Hydropic leiomyoma (HLM) is one of the rare subtypes of uterine leiomyoma. HLM is characterized by diffuse water degeneration and often secondary cystic changes. While HLM enlarged rapidly, especially with hydrothorax and ascites, they were often misdiagnosed as malignant tumors. Pseudo-Meigs’ syndrome is characterized by the presence of hydrothorax and ascites associated with pelvic masses (benign or malignant). Pseudo-Meigs’ syndrome presenting with elevated serum cancer antigen-125 (CA125) is rare and very likely misdiagnosed as a malignancy of the uterus or ovary. Pseudo-meigs’ syndrome with CA125 elevation caused by hydropic leiomyoma is rarer. Here, we reported a 45-year-old Chinese female with ascites, right hydrothorax and a rapidly enlarging pelvic mass. Preoperative abdominal and pelvic CT showed a giant solid mass in the fundus uteri, measuring 20×15×12 cm. The tumor marker CA125 was found to be elevated to 247.7 U/ml and 304.60 U/ml in serum and hydrothorax, respectively. She was initially diagnosed of uterine malignancy and underwent total abdominal hysterectomy and adhesiolysis. The final pathological diagnosis of the specimen was uterine hydropic leiomyoma with cystic changes. After the tumor removal, the ascites and hydrothorax disappeared rapidly and without recurrence. The serum CA125 dropped to 116.90 U/mL on day 7 and 5.6 U/mL on day 40. Follow-up was obtained at 6 months, 1 year, and 2 years after surgery, respectively. The patient's physical signs were all normal, with no recurrence of ascites or hydrothorax.
Identification of eQTL using different sets of single nucleotide polymorphisms associated with carcass and body composition traits in pigs
Authors: Freitas Felipe Andre Oliveira , Brito Luiz F. , Fanalli Simara Larissa , Gonçales Janaína Lustosa , Silva Bruna Pereira Martins , Durval Mariah Castro , Ciconello Fernanda Nery , Oliveira Camila Sabino , Nascimento Lucas Echevarria , Gervásio Izally Carvalho , Gomes Julia Dezen , Moreira Gabriel Costa Monteiro , Silva-Vignato Bárbara , Coutinho Luiz Lehmann , Almeida Vivian Vezzoni , Cesar Aline Silva Mello 
Published: September 2023

Abstract

Background Mapping expression quantitative trait loci (eQTL) in skeletal muscle tissue in pigs is crucial for understanding the relationship between genetic variations and phenotypic expression of carcass traits. Therefore, the primary objective of this study was to evaluate the impact of different sets of single nucleotide polymorphisms (SNP), including those pruned for linkage disequilibrium (LD), derived from SNP chip arrays and RNA-seq data from liver, brain, and skeletal muscle tissues on the identification of eQTL in theLongissimus lumborumtissue, associated with carcass and body composition traits in Large White pigs. SNPs identified from muscle mRNA were combined with SNPs identified in brain and liver tissue transcriptomes, as well as SNPs from the GGP Porcine 50K array. Cis- and trans-eQTL were identified based on the skeletal muscle gene expression level, followed by functional genomic analyses and statistical associations with carcass and body composition traits in Large White pigs. Results The number of cis- and trans-eQTL identified across different sets of SNPs (scenarios) ranged from 261 to 2,539 and from 29 to 13,721, respectively. Furthermore, 6,180 genes were modulated by eQTL in at least one of the scenarios evaluated. The eQTL identified were not significantly associated with carcass and body composition traits based on the association analyses but were significantly enriched for many traits in the "Meat and Carcass" type QTL. The scenarios with the highest number of cis- (n = 304) and trans- (n = 5,993) modulated genes were the unpruned and LD-pruned SNP set scenarios, identified in the mRNA of muscle. These genes include 84 transcription factor coding genes. Conclusions After LD pruning, the set of SNPs identified based on the transcriptome of the skeletal muscle tissue of pigs resulted in the highest number of genes modulated by eQTL. Most eQTL are of the trans type and are involved in genes influencing complex traits in pigs, such as transcription factors and enhancers. Furthermore, the incorporation of SNPs from other genomic regions to the SNPs identified in the porcine skeletal muscle transcriptome contributed to the identification of eQTL that were not identified based on the porcine skeletal muscle transcriptome alone.
A cross-sectional analysis between plasma trace elements and osteoarthritis
Authors: Zhu Yifang 
Published: September 2023

Abstract
Background: The expression level of trace elements and its correlation with inflammation and oxidative stress indicators in osteoarthritis (OA) patients were analyzed, which may lay a foundation for clarifying the role of trace elements in OA pathogenesis and progression.
Methods: A total of 86 subjects participated in the study, including 44 OA patients as case group and 42 healthy people as control group. The inductively coupled plasma mass spectrometer was used to detect copper (Cu), zinc (Zn), calcium (Ca), magnesium (Mg), Iron (Fe), plumbum (Pb), manganese(Mn), selenium (Se), and the differences between two groups were compared. Principal component analysis was used to find the principal variables and logistic regression was used to analyze risk factors for OA. The correlation between trace elements and inflammatory cytokines (TNF-α, IL-6, IL-1β) and oxidative damage markers (MDA, TAC) was analyzed.
Results: The concentrations of Zn, Mg, Fe, Mn and Se were significantly lower in case group than those in the control group, while the plasma levels of Ca were significantly higher than the control group. The concentrations of Cu and Pb in plasma have no difference between two groups. Gender may be one of the factors affecting the expression level of trace elements. The concentrations of Mn and Se in female OA patients were lower than the healthy women, while the concentrations of Zn and Mg in male OA patients were lower than the healthy men, suggesting that the level of trace elements were different in men and women, which should be treated discriminately. The results of correlation analysis indicated that there are intricate correlations among trace elements. Logistic regression analysis suggested that gender and Se were risk factors for OA. Correlation analysis showed that Mn was negatively correlated with inflammatory cytokine IL-6, Fe was positively correlated with IL-1β, Cu was positively correlated with oxidative stress, Zn and Se were negatively correlated with oxidative stress.
Conclusion:
The concentration of Zn, Mg, Fe, Mn, Se and Ca in the plasma of OA patients was changed, in which Mn and Se were lower in female OA patients, Zn and Mg were lower in male OA patients compared to control group. Gender and Se was the risk factor for OA pathogenesis. Trace elements are intricately related with each other. Mn, Fe, Cu, Zn and Se were associated with oxidative stress and inflammatory cytokines.
Supporting recovery, healing and wellbeing with Aboriginal communities of the southeast coast of Australia: a practice-based study of an Aboriginal community-controlled health corganisation’s response to cumulative disasters
Authors: Keevers Lynne , Mackay Maria , Cutmore Sue-Anne , Falzon Kristine , Finlay Summer May , Lukey Samantha , Allan Julaine , Degeling Chris , Everingham Ruth , Fox Mim , Pai Padmini , Olcon Katarzyna 
Published: September 2023

Abstract

Background
The recent crises of bushfires, floods, and the COVID-19 pandemic on the southeast coast of Australia were unprecedented in their extent and intensity. Few studies have investigated responses to cumulative disasters in First Nations communities, despite acknowledgement that these crises disproportionately impact First Nations people. This study was conducted by a team of Aboriginal and non-Aboriginal researchers in partnership with Waminda, South Coast Women’s Health and Wellbeing Aboriginal Corporation, an Aboriginal Community Controlled Health Organisation.
It investigated the collective experiences of people affected by cumulative disasters to identify the practices that support healing, and recovery for Aboriginal communities. The study addresses a knowledge gap of how Waminda, designs, manages and delivers responses to address complex health and social issues in the context of cumulative disasters.
Methods
Underpinned by practice theory this study employed Indigenous-Informed, Narrative Inquiry. Healthcare settings and organisations are turning to practice theory to understand health system responses and service user experience. Culturally-appropriate, multiple interpretive methods were used to collect data including: observations; yarns with Aboriginal community members, yarns with Waminda practitioners, management and board members; interviews-to-the-double, visual images and documentation. The data were collated and analysed using the phases of reflexive thematic analysis.
Results
The paper articulates a suite of culturally safe and place-based practices that enhance social, emotional and spiritual well-being following cumulative disasters. These practice bundles include: adopting a Country-centred conception of local communities; being community-led; viewing care as a collective, relational sociomaterial accomplishment and having fluid boundaries. These practice bundles ‘hang together’ through organising practices including the Waminda Model of Care, staff wellbeing framework and emergency management plan which orient action and manage risks.
Conclusions
The paper suggests crafting responses that focus on assisting communities (re)gain their sense of belonging, hope for the future, control over their lives and their capacities to care for and to be cared for by Country, are key to enhancing healing, health and well-being. ACCHOs are shown to play a crucial role, and their local responses to immediate community needs are grounded in contextual knowledge and use existing resources rather than relying on mainstream system-wide interventions.
DALK combined intralamellar tectonic patch graft: An alternative approach to treat frank corneal perforation
Authors: Xiao Gege , Ben Hanzhi , Gu Shaofeng , Hong Jing 
Published: September 2023

Abstract

Background
Deep anterior lamellar keratoplasty (DALK) has gained popularity in cases of corneal thinning and leaking descemetocele. In this study, we introduced an intralamellar tectonic patch graft in addition to conventional DALK procedures to treat frank cornea perforation.
Methods
This retrospective case series included 13 patients (13 eyes) with frank corneal perforations who underwent DALK combined with intralamellar tectonic patch graft between December 2015 and December 2021. In addition to the standard DALK procedure, the perforation site was repaired with an extra intralamellar tectonic patch graft. The collected data included patient demographics, aetiology, size and location of the corneal perforation, visual acuity, surgical details, and postoperative complications.
Results
Seven patients underwent autologous intralamellar patch grafts, whereas six received allogeneic ones. Anatomical success was achieved in all patients. The mean postoperative follow-up was 33.31 ± 25.96 months (6–73 months). The postoperative visual acuity (0.90 ± 0.65 logMAR) was significantly improved (P = 0.003) compared to the preoperative score (1.74 ± 0.83 logMAR). Best corrected visual acuity (BCVA) improved in 12 eyes (92.3%). The mean endothelial cell density was 2028 ± 463 cells/mm2, 6–12 months postoperatively. There was no recurrence of perforation, and the anterior lamellar graft remained transparent in 12 patients (92.3%). Postoperative complications included epithelial defects (23.1%), ocular hypertension (15.4%), and cataract (7.7%).
Conclusions
DALK combined with intralamellar tectonic patch graft may serve as a secure and effective alternative in treating frank corneal perforation, with reduced complications compared to conventional penetrating keratoplasty.
Exploring adverse events associated with sphingosine-1-phosphate modulators: a pharmacovigilance study using the FDA Adverse Event Reporting System Database
Authors: Wang Ling , Fang Meilin , Liang Weijie , Wang Cunze , Ruan Junshan 
Published: September 2023

Abstract
Background
Sphingosine-1-phosphate receptor (S1PR) modulators have been proposed as therapeutic agents for various diseases. However, the presence of S1PR in multiple tissues may lead to numerous off-target effects of S1PR modulators, potentially limiting their use. There are no real-world reports on adverse effects of S1PR modulators.
Aim
This study aimed to investigate post-marketing adverse event (AE) of S1PR modulators, and to explore risk factors for severe AE.
Method
Disproportionality analyses were performed on adverse event cases of S1PR modulators (2004-2022) collected from the US Food and Drug Administration Adverse Event Reporting System (FAERS). Risk prediction model was developed for severe AE of S1PR modulators using logistic regression analyses.
Results
A total of 95,577 AE reports were retrieved. The prominent risk signals of the S1PR modulators were fatigue, relapses in multiple sclerosis, and headaches. Age, thyroid preparations, and monoclonal antibodies were independent risk factors for severe AE (p < 0.05). The risk prediction model for severe AE and the corresponding nomogram exhibited discrimination ability and clinical applicability in both training set (AUC 0.6102) and validation sets (AUC 0.6079).
Conclusion
Our post-marketing pharmacovigilance analysis revealed the types and incidence of AE related to S1PR modulators. The nomogram may be useful for rapid clinical assessment on the occurrence of severe AE.