bluuebunny/crossref_metadata_2025_split huggingface dataset:
A qualitative investigation exploring neighbourhood environment, risks and fear of falling, and fall prevention strategies among urban-dwelling older adults in a high-density city
Authors: Zhang Chun-Qing , Zhang Ru , Baker Julien S. , Hagger Martin S. , Hamilton Kyra 
Published: January 2023

AbstractFalls in older adulthood can have serious consequences. It is therefore important to identify ways to prevent falls, particularly from the voice of older adults. Bottom-up qualitative exploration of the perspectives of older adults can provide rich insights that can help inform the development of effective fall prevention programmes. However, currently there is a dearth of such empirical data, especially among urban-dwelling older adults in high-density cities where fall rates are high. The current study aimed to examine qualitatively perceptions of neighbourhood physical environment in relation to falls, perceived risks and fear of falling, and strategies and behaviours for fall prevention in a sample of urban-dwelling older adults in the high-density city of Hong Kong. Face-to-face semi-structured in-depth interviews were conducted with 50 community-dwelling older adults. Interviews were transcribed verbatim and analysed using thematic analysis techniques. Five general themes were revealed: risks and circumstances of falls, consequences of falls, fear of falling and its consequences, neighbourhood environment, and strategies and behaviours of fall prevention. While older adults discussed the risks of falling and held a fear of falling, these beliefs were mixed. In addition to fall prevention strategies (e.g. keep balance), current findings highlighted the importance of establishing protective factors (e.g. flat and even walking paths) and reducing risk factors (e.g. neighbourhood clutter) in neighbourhood environments. For urban-dwelling older adults in high-density cities, current findings highlight the importance of focusing efforts at the built environment level in addition to strategies and behaviours of fall prevention at the individual level.
THEORIZING AREAS OF LAW: A TAXONOMY OF SPECIAL JURISPRUDENCE
Authors: Khaitan Tarunabh , Steel Sandy 
Published: January 2023

ABSTRACTThis paper provides a taxonomy of the different kinds of theory that may be offered of an area of law. We distinguish two basic types of philosophical accounts in special jurisprudence: nonnormative accounts and normative accounts. Section II explains the two central subspecies of nonnormative accounts of areas of law: (i) conceptual and ontological theories and (ii) reason-tracking causal theories. Section III explores normative theories of areas of law. Normative accounts subdivide into detached and committed normative accounts. Detached or committed normative accounts can be subdivided further into the following cross-cutting categories: (i) pro tanto or all-things-considered, (ii) hyper-reformist or practice-dependent, (iii) taxonomical or substantive. Section IV shows that our taxonomy does not presume a prior commitment to any particular school in general jurisprudence. This paper clarifies methodological confusion that exists in theorizing about areas of law, and contributes to the subfield of thinking generally about special jurisprudence.
Changing faces of political women in Tokyo
Authors: Estévez-Abe Margarita 
Published: January 2023

AbstractThis article has two objectives. One is to explain the rise of female political representation in local assemblies in Tokyo's 23 Special Wards. The other is to examine how political women in Japan have or have not changed since the publication of Susan Pharr's Political Women in Japan in 1981. When Tokyo first saw the emergence of a new type of local assembly women in the 1990s, they consisted of well-educated suburban housewives who led the Seikatsusha Nettowaku movement. In the past 15 years, however, Tokyo has witnessed a decline in ‘housewife politicians’ and a further diversification in the types of political women. This article pays special attention to a new type of political women called Mama Giin (literally, mommy politicians). Mama Giin are professional working mothers, who have become local assembly women to address deficiencies in childcare services. Their numbers increased as socio-economic changes and party realignment reshaped supply and demand for female candidates in Tokyo. Most of them accept the gendered responsibilities for childcare very much like Pharr's New Women did in the 1970s. The younger cohorts of highly educated women enjoy greater job options and life choices unavailable to the New Women of their mothers' generation. However, they do not necessarily challenge Japan's patriarchy. This article examines the biographies of female local politicians in Tokyo's 23 Special Ward assemblies to understand the rise of Mama Giin.
UNITARY REPRESENTATIONS OF CYCLOTOMIC HECKE ALGEBRAS AT ROOTS OF UNITY: COMBINATORIAL CLASSIFICATION AND BGG RESOLUTIONS
Authors: Bowman Chris , Norton Emily , Simental José 
Published: January 2023

AbstractWe relate the classes of unitary and calibrated representations of cyclotomic Hecke algebras, and, in particular, we show that for the most important deformation parameters these two classes coincide. We classify these representations in terms of both multipartition combinatorics and as the points in the fundamental alcove under the action of an affine Weyl group. Finally, we cohomologically construct these modules via BGG resolutions.
Effects of Sea Spray on the Simulated Tropical Cyclone Development: Dependence on Surface Drag Coefficient Parameterization
Authors: Duan Ziqiang , Wang Yuqing , Li Yuanlong 
Published: January 2023

AbstractWave breaking under strong wind conditions in tropical cyclones (TCs) can generate sea spray droplets, which, during their suspension in air, release sensible heat due to the air‐sea temperature difference while absorb sensible heat from the environment when they evaporate and release latent heat to the environment. Since the spray mass flux is a function of surface drag coefficient (CD), the effect of spray on TC evolution should depends on CD parameterization, while this has not been addressed so far. This study examines the effects of sea spray on the simulated TC evolution with two different CD parameterizations (the Weather Research and Forecasting (WRF) default scheme and the Donelan scheme). Results show that during the primary intensification stage, the TC with spray effect becomes stronger than that without spray when the WRF CD scheme is used, but becomes weaker when the Donelan CD scheme is used. This occurs because CD is maximum outside the radius of maximum wind (RMW) with the Donelan scheme, which produces relatively large spray‐mediated latent heat flux outside the RMW, which is unfavorable for TC intensification. The difference is enlarged by a feedback between spray and TC intensification involving the inertial stability and surface friction‐induced radial inflow. However, in the mature stage, the simulated TCs with spray become stronger no matter which CD scheme is used. In addition, the spray effect on the TC inner‐core size evolution also weakly depends on the drag parameterization. When CD is relatively greater outside the RMW, the inclusion of the spray effect would lead to the inner‐core size increase.
A (Simplified) Biogeochemical Numerical Model to Predict Saturation, Porosity and Permeability During Microbially Induced Desaturation and Precipitation
Authors: Wang Liya , van Paassen Leon , Pham Vinh , Mahabadi Nariman , He Jia , Gao Yunqi 
Published: January 2023

AbstractMicrobially Induced Desaturation and Precipitation (MIDP) through denitrification is an emerging ground improvement method in which indigenous nitrate reducing bacteria are stimulated to introduce biogas, biominerals and biomass in the soil matrix. In this study, a numerical model is developed to evaluate the effect of biogas, biominerals and biomass on the hydraulic properties of soils treated with MIDP. The proposed model couples the biochemical conversions to changes of porosity and water saturation and predicts changes in permeability through two separate power law equations. Experimental studies from the literature are used to calibrate the model. Comparing the results with other studies on bioclogging or biomineralization in porous media reveals that the combined production of biogas, biomass, and biominerals results in efficient clogging, in the sense that only a small amount of products leads to a substantial permeability reduction. Based on this comparison, the authors postulate that biogenic gas bubbles preferably form within the larger pore bodies. The presence of biogenic gas in the larger pore bodies forces calcium carbonate minerals and biomass to be formed mainly at the pore throats. The interaction between the different phases results in more efficient clogging than observed in other studies which focus on a single product only.
ZBTB7A suppresses glioblastoma tumorigenesis through the transcriptional repression of EPB41L5
Authors: Jeong Ji-Hoon , Park Seung-Ho , Kim Hyunhee , Nam Hae Yun , Kim Sung-Hak , Jeong Minseok , Kong Min-Jeong , Son Jihyun , Jeong Ji-Eun , Song Ji-Hye , Kim Seong Who , Choi Kyung-Chul 
Published: January 2023

AbstractGlioblastoma multiforme (GBM), the most aggressive and malignant glioma, has a poor prognosis. Although patients with GBM are treated with surgery, chemotherapy, and radiation therapy, GBM is highly resistant to treatment, making it difficult and expensive to treat. In this study, we analyzed the Gene Expression Profiling Interactive Analysis dataset, the Cancer Genome Atlas dataset, and Gene Expression Omnibus array data. ZBTB7A (also called FBI1/POKEMON/LRF) was found to be highly expressed in low-grade glioma but significantly downregulated in patients with GBM. ZBTB7A is a transcription factor that plays an important role in many developmental stages, including cell proliferation. The activation of epithelial-mesenchymal transition (EMT) is a key process in cancer progression and metastasis. Erythrocyte membrane protein band 4.1 like 5 (EPB41L5) is an essential protein for EMT progression and metastasis in various types of cancer. We found that ZBTB7A depletion in U87 cells induced GBM progression and metastasis. Based on RNA sequencing data, ZBTB7A directly binds to the promoter of the EPB41L5 gene, reducing its expression and inhibiting GBM progression. We demonstrated that ZBTB7A dramatically inhibits GBM tumor growth through transcriptional repression of EPB41L5. Thus, both ZBTB7A and EPB41L5 may be potential biomarkers and novel therapeutic targets for GBM treatment. Overall, we discovered the role of a novel tumor suppressor that directly inhibits GBM progression (ZBTB7A) and identified EPB41L5 as a therapeutic target protein for patients with GBM.
Stable colonization of Akkermansia muciniphila educates host intestinal microecology and immunity to battle against inflammatory intestinal diseases
Authors: Wang Bin , Chen Xuheng , Chen Zhiyuan , Xiao Huiwen , Dong Jiali , Li Yuan , Zeng Xiaozhou , Liu Jinjian , Wan Guoyun , Fan Saijun , Cui Ming 
Published: January 2023

AbstractGut microbial preparations are widely used in treating intestinal diseases but show mixed success. In this study, we found that the therapeutic efficacy ofA. muciniphilafor dextran sodium sulfate (DSS)-induced colitis as well as intestinal radiation toxicity was ~50%, and mice experiencing a positive prognosis harbored a high frequency ofA. muciniphilain the gastrointestinal (GI) tract. Stable GI colonization ofA. muciniphilaelicited more profound shifts in the gut microbial community structure of hosts. Coexisting withA. muciniphilafacilitated proliferation and reprogrammed the gene expression profile ofLactobacillus murinus, a classic probiotic that overtly responded toA. muciniphilaaddition in a time-dependent manner. Then, a magnetic-drove, mannose-loaded nanophase material was designed and linked to the surface ofA. muciniphila. The modifiedA. muciniphilaexhibited enhancements in inflammation targeting and intestinal colonization under an external magnetic field, elevating the positive-response rate and therapeutic efficacy against intestinal diseases. However, the unlinked cocktail containingA. muciniphilaand the delivery system only induced negligible improvement of therapeutic efficacy. Importantly, heat-inactivatedA. muciniphilalost therapeutic effects on DSS-induced colitis and was even retained in the GI tract for a long time. Further investigations revealed that the modifiedA. muciniphilawas able to drive M2 macrophage polarization by upregulating the protein level of IL-4 at inflammatory loci. Together, our findings demonstrate that stable colonization of liveA. muciniphilaat lesion sites is essential for its anti-inflammatory function.
Active terahertz beam steering based on mechanical deformation of liquid crystal elastomer metasurface
Authors: Zhuang Xiaolin , Zhang Wei , Wang Kemeng , Gu Yangfan , An Youwen , Zhang Xueqian , Gu Jianqiang , Luo Dan , Han Jiaguang , Zhang Weili 
Published: January 2023

AbstractActive metasurfaces are emerging as the core of next-generation optical devices with their tunable optical responses and flat-compact topography. Especially for the terahertz band, active metasurfaces have been developed as fascinating devices for optical chopping and compressive sensing imaging. However, performance regulation by changing the dielectric parameters of the integrated functional materials exhibits severe limitations and parasitic losses. Here, we introduce a C-shape-split-ring-based phase discontinuity metasurface with liquid crystal elastomer as the substrate for infrared modulation of terahertz wavefront. Line-focused infrared light is applied to manipulate the deflection of the liquid crystal elastomer substrate, enabling controllable and broadband wavefront steering with a maximum output angle change of 22° at 0.68 THz. Heating as another control method is also investigated and compared with infrared control. We further demonstrate the performance of liquid crystal elastomer metasurface as a beam steerer, frequency modulator, and tunable beam splitter, which are highly desired in terahertz wireless communication and imaging systems. The proposed scheme demonstrates the promising prospects of mechanically deformable metasurfaces, thereby paving the path for the development of reconfigurable metasurfaces.
Anti-BCMA CAR T-cell therapy CT103A in relapsed or refractory AQP4-IgG seropositive neuromyelitis optica spectrum disorders: phase 1 trial interim results
Authors: Qin Chuan , Tian Dai-Shi , Zhou Luo-Qi , Shang Ke , Huang Liang , Dong Ming-Hao , You Yun-Fan , Xiao Jun , Xiong Ying , Wang Wen , Pang Hao , Guo Jing-Jing , Cai Song-Bai , Wang Di , Li Chun-Rui , Zhang Min , Bu Bi-Tao , Wang Wei 
Published: January 2023

AbstractChimeric antigen receptor (CAR) T-cell therapy that targets B-cell maturation antigen (BCMA) have great potentials in autoimmune diseases and could be novel therapeutics for relapsed/refractory neuromyelitis optica spectrum disorder (NMOSD). To evaluate the safety and efficacy of the CT103A, a self-developed BCMA-targeting CAR construct against BCMA, in patients with AQP4-IgG seropositive NMOSD, an ongoing, investigator-initiated, open-label, single-arm, phase 1 clinical trial is conducted at our center. In total, 12 patients were administered with a CAR-BCMA infusion. Ten of the 12 patients dosed were women (83.3%), with a median age of 49.5 years (range, 30–67). were The most common events of grade 3 or higher were hematologic toxic effects. Seven patients (58%) developed infections, but no grade 4 infections occurred. Cytokine release syndrome was reported in all patients with only events of grade 1 or 2 observed. During the follow-up of a median 5.5 months, 11 patients had no relapse; all patients generally reported improvement in disabilities and quality-of-life outcomes; 11 patients’ AQP-4 antibodies in serum showed a downward trend by the cutoff date. CAR T-cell expansion was associated with responses, and persisted more than 6 months post-infusion in 17% of the patients. In summary, CAR T-cell therapy shows a manageable safety profile and therapeutic potentials for patients with relapsed/refractory AQP4-IgG seropositive NMOSD. Another expansion phase is currently underway to determine the safety and efficacy of CAR T-BCMA infusion in patients with other neuro-inflammatory diseases.
Synaptic gradients transform object location to action
Authors: Dombrovski Mark , Peek Martin Y. , Park Jin-Yong , Vaccari Andrea , Sumathipala Marissa , Morrow Carmen , Breads Patrick , Zhao Arthur , Kurmangaliyev Yerbol Z. , Sanfilippo Piero , Rehan Aadil , Polsky Jason , Alghailani Shada , Tenshaw Emily , Namiki Shigehiro , Zipursky S. Lawrence , Card Gwyneth M. 
Published: January 2023

AbstractTo survive, animals must convert sensory information into appropriate behaviours1,2. Vision is a common sense for locating ethologically relevant stimuli and guiding motor responses3–5. How circuitry converts object location in retinal coordinates to movement direction in body coordinates remains largely unknown. Here we show through behaviour, physiology, anatomy and connectomics in Drosophila that visuomotor transformation occurs by conversion of topographic maps formed by the dendrites of feature-detecting visual projection neurons (VPNs)6,7 into synaptic weight gradients of VPN outputs onto central brain neurons. We demonstrate how this gradient motif transforms the anteroposterior location of a visual looming stimulus into the fly’s directional escape. Specifically, we discover that two neurons postsynaptic to a looming-responsive VPN type promote opposite takeoff directions. Opposite synaptic weight gradients onto these neurons from looming VPNs in different visual field regions convert localized looming threats into correctly oriented escapes. For a second looming-responsive VPN type, we demonstrate graded responses along the dorsoventral axis. We show that this synaptic gradient motif generalizes across all 20 primary VPN cell types and most often arises without VPN axon topography. Synaptic gradients may thus be a general mechanism for conveying spatial features of sensory information into directed motor outputs.
Neonatal imprinting of alveolar macrophages via neutrophil-derived 12-HETE
Authors: Pernet Erwan , Sun Sarah , Sarden Nicole , Gona Saideep , Nguyen Angela , Khan Nargis , Mawhinney Martin , Tran Kim A. , Chronopoulos Julia , Amberkar Dnyandeo , Sadeghi Mina , Grant Alexandre , Wali Shradha , Prevel Renaud , Ding Jun , Martin James G. , Thanabalasuriar Ajitha , Yipp Bryan G. , Barreiro Luis B. , Divangahi Maziar 
Published: January 2023

AbstractResident-tissue macrophages (RTMs) arise from embryonic precursors1,2, yet the developmental signals that shape their longevity remain largely unknown. Here we demonstrate in mice genetically deficient in 12-lipoxygenase and 15-lipoxygenase (Alox15−/− mice) that neonatal neutrophil-derived 12-HETE is required for self-renewal and maintenance of alveolar macrophages (AMs) during lung development. Although the seeding and differentiation of AM progenitors remained intact, the absence of 12-HETE led to a significant reduction in AMs in adult lungs and enhanced senescence owing to increased prostaglandin E2 production. A compromised AM compartment resulted in increased susceptibility to acute lung injury induced by lipopolysaccharide and to pulmonary infections with influenza A virus or SARS-CoV-2. Our results highlight the complexity of prenatal RTM programming and reveal their dependency on in trans eicosanoid production by neutrophils for lifelong self-renewal.
A dataset for plain language adaptation of biomedical abstracts
Authors: Attal Kush , Ondov Brian , Demner-Fushman Dina 
Published: January 2023

AbstractThough exponentially growing health-related literature has been made available to a broad audience online, the language of scientific articles can be difficult for the general public to understand. Therefore, adapting this expert-level language into plain language versions is necessary for the public to reliably comprehend the vast health-related literature. Deep Learning algorithms for automatic adaptation are a possible solution; however, gold standard datasets are needed for proper evaluation. Proposed datasets thus far consist of either pairs of comparable professional- and general public-facing documents or pairs of semantically similar sentences mined from such documents. This leads to a trade-off between imperfect alignments and small test sets. To address this issue, we created the Plain Language Adaptation of Biomedical Abstracts dataset. This dataset is the first manually adapted dataset that is both document- and sentence-aligned. The dataset contains 750 adapted abstracts, totaling 7643 sentence pairs. Along with describing the dataset, we benchmark automatic adaptation on the dataset with state-of-the-art Deep Learning approaches, setting baselines for future research.
A high-adaptability nozzle-array printing system based on a set covering printing planning model for printed display manufacturing
Authors: Wang Yixin , Chen Jiankui , Yin Zhouping , Li Yiqun 
Published: January 2023

AbstractInkjet printing technology is expected to enhance printed display mass production technology in the future. Nozzle-array printheads form the basis for printed display mass production applications. However, jet instability caused by air bubble entrapment and nozzle wettability changes during the printing process is a major challenge in the application of this technology. To adapt to possible nozzle abnormalities, a high-adaptability nozzle-array printing system based on a set covering printing planning (SCPP) model for printed display manufacturing is designed in this study. The study consists of two parts. First, a printing system based on multistep visual inspection and closed-loop feedback is proposed to accurately detect and screen abnormal nozzle positions. Notably, the inkjet printing system can identify nozzles with abnormal ejection characteristics and ensure that the remaining nozzles work accurately and stably. Then, an SCPP model is established for display pixel printing planning by using the remaining normal nozzles on the nozzle-array printhead. This model can output the most efficient printing path and nozzle printing action and can adapt to any pixel pattern, nozzle type, and abnormal nozzle distribution. The system and technology are highly adaptable and scalable for fabricating large-area printed display devices.