bluuebunny/crossref_metadata_2025_split huggingface dataset:
Superb Microvascular Imaging for the Differentiation of Benign and Malignant Breast Lesions: A System Review and Meta‐Analysis
Authors: Chen Si‐han , Xiang Xiao‐zhen , Che Peng‐fei , Hu Bing , Shui Dian‐ya , Zhao Yun , Wang Li 
Published: December 2022

ObjectiveTo evaluate the diagnostic performance of SMI in the diagnosis of benign and malignant breast lesions.MethodsA systematic search of PubMed, EMBASE, Cochrane, OVID, SCI, and SCOPUS was performed to find relevant studies which applied SMI to differentiate benign and malignant breast lesions. All the studies were published before October 10, 2022. Only studies published in English were collected. Quality Assessment of Diagnostic Accuracy Studies‐2 (QUADAS‐2) tool was applied to assess the quality of the included studies. Summary receiver operating characteristic (SROC) modeling was also performed to the diagnostic performance of SMI in the diagnosis of benign and malignant breast lesions. Subgroup analyses and meta‐regression were performed to find out the heterogeneity.ResultsTwenty studies which include a total of 2873 lesions (1748 benign and 1125 malignant) in 2740 patients were evaluated in this meta‐analysis. The summary sensitivity and specificity were 0.82 (95% confidence interval [CI]: 0.76–0.86), 0.70 (95% CI: 0.64–0.76) for SMI vascular degree, 0.77 (95% CI: 0.67–0.84), 0.79 (95% CI: 0.75–0.83) for SMI vascular distribution, 0.78 (95% CI: 0.70–0.84), 0.75 (95% CI: 0.69–0.80) for SMI vascular morphology, 0.81 (95% CI: 0.72–0.87), 0.80 (95% CI: 0.75–0.85) SMI penetration vessel. For SMI overall vascular features, the summary sensitivity and summary specificity were 0.74 (95% CI: 0.61–0.84) and 0.80 (95% CI: 0.76–0.84). The result of subgroup analysis and meta‐analysis showed malignant rate and country might be the cause of heterogeneity of diagnostic accuracy of vascular grade and morphology.ConclusionSMI vascular features have high sensitivity and specificity in the differentiation of benign and malignant lesions. Future international multicenter studies in various regions with large sample size are required to confirm these findings.
Pediatric Bilateral Vocal Cord Immobility: New Treatment With Preservation of Voice
Authors: Trozzi Marilena , Torsello Miriam , Meucci Duino , Micardi Mariella , Tropiano Maria L. , Balduzzi Sara , Ossandon Avetikian Alejandra , Salvati Antonio , Bottero Sergio 
Published: December 2022

ObjectivesPediatric bilateral vocal cord immobility (BVCI) represents a severe life‐threatening condition that often causes severe dyspnea. Endoscopic arytenoid lateral abduction (EALA) is a relatively new, secure, minimal‐invasive surgical technique. The present prospective observational study aims to evaluate the effects of EALA in terms of respiratory function, voice quality, and swallowing capabilities.MethodsTwenty‐one pediatric patients with BVCI underwent EALA. Eleven out of 21 patients had tracheostomy at the time of surgery. Pre and postoperative functional assessments included endoscopic evaluation, maximum phonation time, pediatric Voice Handicap Index (pVHI), GIRBAS Scale criteria, and Montreal Children's Hospital Feeding scale (MCH‐Feeding scale). peak tidal inspiratory flow or peak inspiratory flow (PIF) and number of desaturations/hour (ODI/h) were evaluated in patients without tracheostomy.ResultsPostoperative endoscopy showed glottic airway improvement in all patients. Average time for decannulation was 4.6 weeks. One patient has not yet been decannulated. No major complications occurred. In patients without tracheostomy, we observed a significant improvement of ODI/h and PIF after surgery (p < 0.05) as expected. PVHI, MCH‐Feeding scale, and GIRBAS score significantly worsened 1 month after surgical intervention (p < 0.05). One year after surgery, however, all values, except for B and A parameters of the GIRBAS score, returned to levels comparable to those preoperative.ConclusionsEALA represents a simple, safe and effective solution in pediatric patients with BVCI, avoiding tracheostomy, allowing early decannulation, preserving swallowing function, and maintaining good quality voice.Level of Evidence4 Laryngoscope, 133:2325–2332, 2023
Effects of Various Cell Surface Engineering Reactions on the Biological Behavior of Mammalian Cells
Authors: Cai Fengying , Ren Yafeng , Dai Jiajia , Yang Jianmin , Shi Xianai 
Published: December 2022

AbstractCell surface engineering technologies can regulate cell function and behavior by modifying the cell surface. Previous studies have mainly focused on investigating the effects of cell surface engineering reactions and materials on cell activity. However, they do not comprehensively analyze other cellular processes. This study exploits covalent bonding, hydrophobic interactions, and electrostatic interactions to modify the macromolecules succinimide ester‐methoxy polyethylene glycol (NHS‐mPEG), distearoyl phosphoethanolamine‐methoxy polyethylene glycol (DSPE‐mPEG), and poly‐L‐lysine (PLL), respectively, on the cell surface. This work systematically investigates the effects of the three surface engineering reactions on the behavior of human umbilical vein endothelial cells (HUVECs) and human skin fibroblasts, including viability, growth, proliferation, cell cycle, adhesion, and migration. The results reveals that the PLL modification method notably affects cell viability and G2/M arrest and has a short modification duration. However, the DSPE‐mPEG and NHS‐mPEG modification methods have little effect on cell viability and proliferation but have a prolonged modification duration. Moreover, the DSPE‐mPEG modification method highly affects cell adherence. Further, the NHS‐mPEG modification method can significantly improve the migration ability of HUVECs by reducing the area of focal adhesions. The findings of this study will contribute to the application of cell surface engineering technology in the biomedical field.
Evaluation of the effectiveness of a training programme for nurses regarding augmentative and alternative communication with intubated patients using Kirkpatrick's model: A pilot study
Authors: Momennasab Marzieh , Mohammadi Fatemeh , DehghanRad Fereshteh , Jaberi Azita 
Published: December 2022

AbstractAimCommunicating with conscious intubated patients who are unable to communicate verbally is one of the challenges faced by intensive care unit (ICU) nurses. The present study was conducted to evaluate the effectiveness of a training programme for nurses regarding augmentative and alternative communication (AAC) with intubated patients using Kirkpatrick's model.DesignThis study had a one‐group, before–after, quasi‐experimental design.MethodsTotally, 45 nurses working in ICUs participated in a blended training programme using AAC strategies to communicate with intubated patients. Their contribution was evaluated based on Kirkpatrick's model at four levels. The study data were collected using the “satisfaction and ease questionnaire,” “observation checklist” and “communication knowledge test.” Then, the data were analysed using the SPSS 22 software and p < 0.05 was considered statistically significant.ResultsMost participants were satisfied with the implementation of the programme. The nurses' mean score of communication knowledge increased after the intervention (p < 0.05). The results of evaluation of the third and fourth levels of Kirkpatrick's model also showed an increase in the success of communication, use of AAC, and satisfaction with and ease of communication (p < 0.001).ImplicationShort‐term and long‐term effects of the blended training programme about AAC were investigated using Kirkpatrick's model. The results indicated the positive effect of the programme on the quality of the nurses’ communication with intubated patients, their understanding of the patients’ messages and meeting the patients’ needs at a more desirable level. Thus, nurses and other staff are recommended to use this simple method of communication with patients to provide better services. In addition, further quantitative and qualitative studies are suggested to assess these communication strategies in other patients with impaired consciousness.
Improved curing reactivity, thermal resistance and mechanical properties of furylamine‐based benzoxazine using melamine as an amine source
Authors: Ye Jiajia , Fan Zilin , Zhang Shuai , Liu Xiaobo 
Published: December 2022

AbstractBenzoxazine resin is known as a high‐performance thermosetting resin, but the relatively high curing temperature and low cross‐linking density limit its broad application. The furylamine based benzoxazines possess great comprehensive performances and show great potential as bio‐based materials. In this work, the benzoxazine precursors (BAfa‐ma) containing furylamine were synthesized by using melamine as diamine to promote the curing reactivity and thermal resistance of furylamine based benzoxazines. The Fourier transform infrared (FT‐TR) and proton nuclear magnetic resonance (1H NMR) spectroscopy were used to confirm the chemical structures of BAfa‐ma, and differential scanning calorimetric (DSC), and thermogravimetric analysis (TGA) were applied to verify the curing behavior and performance of obtained polymers. It is showed that there are less benzoxazine rings in BAfa‐ma as more melamine introduced, on the contrary, more phenolic hydroxyls and secondary amines appeared as built‐in catalysts. What's more, BAfa‐ma have higher reactivity, shorter gelation time and lower curing temperature. Additionally, more melamine would lead to higher crosslinking density and higher thermal resistance, poly(BAfa‐70ma) shows Tg up to 318.6 and 76.4°C higher than that of poly(BAfa). Moreover, the mechanical and dielectric properties of the corresponding glass fiber reinforced composites laminates are also investigated, and it is found that proper amount of melamine may be beneficial for higher mechanical strength.
Treatment and mortality of hemophagocytic lymphohistiocytosis in critically ill children: A systematic review and meta‐analysis
Authors: Tan Claire Jing‐Wen , Ng Zheng Qin , Bhattacharyya Rajat , Sultana Rehena , Lee Jan Hau 
Published: December 2022

AbstractObjectiveRisk factors of mortality in critically ill children with hemophagocytic lymphohistiocytosis (HLH) are not well described. This systematic review aims to determine overall mortality of critically ill children with HLH, and describes etiologies, treatment, and pediatric intensive care unit (PICU) support employed.Data sourcesPubMed, Embase, Web of Science, CINAHL, and Cochrane Library from inception until February 28, 2022.Study selectionObservational studies and randomized controlled trials reporting children aged 18 years or below, diagnosed with HLH and admitted to the PICU.Data extractionEtiologies, treatment modalities, PICU therapies, and mortality outcomes were summarized. Random‐effects meta‐analysis was performed.Data synthesisTotal 36 studies (total patients = 493, mean age: 49.5 months [95% confidence interval (CI): 30.9–79.5]) were included. Pooled mortality rate was 32.6% (95% CI: 23.4–42.4). The most frequent etiologies for HLH were infections (53.3%) and primary HLH (12.8%), while the remaining cases were due to other causes of secondary HLH, including autoimmune diseases, malignancy, and drug‐induced and idiopathic HLH. Pooled mortality rate was higher in primary than secondary HLH (72.2%, 95% CI: 57.8–84.5 vs. 23.9%, 95% CI: 14.4–35.02; p < .01). Univariate analysis found that treatment with etoposide was associated with higher mortality, while intravenous immunoglobulins (IVIGs) were associated with lower mortality. Conversely, multivariable analysis adjusted for etiology demonstrated no association between etoposide and IVIG use, and mortality. Twenty‐one studies (total patients = 278) had detailed information on PICU therapies. Mechanical ventilation (MV), continuous renal replacement therapy, and inotropes were used in 107 (38.5%), 66 (23.7%), and 51 patients (18.3%), respectively. Need for MV was associated with increased risk of mortality (mean difference = 28%, 95% CI: 9–47).ConclusionCritically ill children with HLH have high mortality rates and require substantial PICU support. Collaborative work between multiple centers with standardized data collection can potentially provide more robust data.
Pediatric refractory immune thrombocytopenia: A systematic review
Authors: Ibrahim Layan , Dong Selina X. , O'Hearn Katie , Grimes Amanda B. , Kaicker Shipra , FritchLilla Stephanie , Breakey Vicky R. , Grace Rachael F. , Lebensburger Jeffrey D. , Klaassen Robert J. , Lambert Michele 
Published: December 2022

AbstractPediatric immune thrombocytopenia (ITP) is an acquired disorder associated with autoimmune destruction and impairment of platelet production in children. Some children exhibit poor or transient response to ITP‐directed treatments and are referred to as having refractory ITP (rITP). There is currently no consensus on the definition of rITP, nor evidence‐based treatment guidelines for patients with rITP. After a survey of pediatric ITP experts demonstrated lack of consensus on pediatric rITP, we pursued a systematic review to examine the reported clinical phenotypes and treatment outcomes in pediatric rITP. The search identified 253 relevant manuscripts; following review, 11 studies proposed a definition for pediatric rITP with no consensus amongst them. Most definitions included suboptimal response to medical management, while some outlined specific platelet thresholds to define this suboptimal response. Common attributes identified in this study should be used to propose a comprehensive definition, which will facilitate outcome comparisons of future rITP studies.
Determinants of delayed childhood cancer care in low‐ and middle‐income countries: A systematic review
Authors: Cotache‐Condor Cesia , Kantety Vinootna , Grimm Andie , Williamson Jahsarah , Landrum Kelsey R , Schroeder Kristin , Staton Catherine , Majaliwa Esther , Tang Shenglan , Rice Henry E. , Smith Emily R. 
Published: December 2022

AbstractEarly access to care is essential to improve survival rates for childhood cancer. This study evaluates the determinants of delays in childhood cancer care in low‐ and middle‐income countries (LMICs) through a systematic review of the literature. We proposed a novel Three‐Delay framework specific to childhood cancer in LMICs by summarizing 43 determinants and 24 risk factors of delayed cancer care from 95 studies. Traditional medicine, household income, lack of transportation, rural population, parental education, and travel distance influenced most domains of our framework. Our novel framework can be used as a policy tool toward improving cancer care and outcomes for children in LMICs.
Effect of ply thickness on tensile and bending performances of carbon fiber reinforced thermoplastic unidirectional laminate
Authors: Liu Haolin , Ma Xinqi , Jiang Lin , Sang Lin , Hou Wenbin , Zhang Zhuqing , Wu Haihong 
Published: December 2022

AbstractIt has been explored that thin ply would improve the mechanical performances of carbon fiber reinforced epoxy composites laminate. It has not been known whether there are similar effects on thermoplastic composites. In this article, carbon fiber reinforced polyamide 6 (CF/PA6) unidirectional fabrics with two thicknesses of 0.045 and 0.105 mm were used to fabricate the unidirectional laminate (UDL). Tensile and bending behaviors of the UDL were recorded with a digital image correlation (DIC) system, their damage macro‐morphologies were observed with high‐speed camera during loading. The fracture microstructures of the samples were observed with SEM and optic microscope. The results showed that the tensile and bending strengths of the samples with 0.045 mm thick are 79.8% and 24.8% higher than that with 0.105 mm thick. Thinning ply can inhibit the crack expanding, and the time from crack originating to fracture of the sample is larger than that of the thick ply one. Morphologies of the fractures revealed that the crack mainly expanded in the matrix along the loading direction for thin‐ply laminate, while the crack developed in the fiber cluster for thick‐ply laminate. The results also revealed that the mechanical properties of the laminate can be improved obviously by using thin‐ply.
The association between sleep and physical activity with persisting postconcussion symptoms among adolescent athletes
Authors: Neely Linda M. , Smulligan Katherine L. , Wingerson Mathew J. , Seehusen Corrine N. , Simon Stacey L. , Wilson Julie C. , Howell David R. 
Published: December 2022

AbstractBackgroundBoth sleep duration and physical activity following concussion may influence subsequent recovery. Objective measurement of sleep and physical activity behavior via wearable technology may provide insights into their association with concussion recovery.ObjectiveTo determine whether sleep behavior (eg, duration, timing) and/or physical activity (steps/day, or exercise frequency, duration, intensity) in the first month after adolescent sports‐related concussion are associated with developing persisting postconcussion symptoms (PPCS).DesignCase–control.SettingOutpatient sports medicine clinic.ParticipantsThe study prospectively enrolled adolescent athletes who sustained a concussion (N = 49, age = 14.8 ± 1.8 years; 51% female) who were evaluated within 14 days of concussion (mean = 6.7 ± 2.7 days) and followed uvia sleep/physical activity monitoring for the subsequent 2 weeks.Main Outcome MeasuresParticipants wore a monitor to track sleep (sleep time, wake time, and time spent awake in bed at night) and physical activity (average steps/day, exercise frequency, exercise duration) behavior for 2 weeks after initial assessment. Participants were followed until symptom resolution, and the main outcome of interest was development of PPCS (symptom duration >28 days). A multivariable logistic regression model was used to examine associations between physical activity and sleep behavior with PPCS.ResultsOf the 49 participants, 47% (n = 23, mean symptom resolution = 57 ± 23 days post injury) developed PPCS and 53% (n = 26, mean symptom resolution = 15 ± 7 days post injury) did not. Univariable analysis showed that the PPCS group took fewer steps/day (7526 ± 2975 vs. 9803 ± 3786 steps/day; p = .02), exercised less frequently (2.5 ± 2.2 vs. 4.4 ± 2.1 days/week; p = .005), and spent more time in bed awake (1.2 ± 0.3 vs. 0.8 ± 0.3 h/night; p = .03) than the no PPCS group. Multivariable results indicated the odds of developing PPCS significantly increased with fewer exercise session/week (adjusted odds ratio = 1.96, 95% confidence interval = 1.09, 3.51, p = .024).ConclusionsMore exercise sessions that were longer than 15 minutes during concussion recovery was associated with a lower risk of developing PPCS, whereas sleep and other physical activity measures were not. Further studies regarding exercise duration and intensity are needed. Clinicians may consider advising patients to optimize sleep and physical activity during concussion recovery.
Additively Manufactured Micro‐ and Nano‐ Al/PVDF Ignition Sensitivity and Burning Characterization
Authors: Uhlenhake Kyle E. , Collard Diane N. , Hoganson Alexander C. , Brown Alex D. , Fox Sara , Örnek Metin , Rhoads Jeffrey F. , Son Steven F. 
Published: December 2022

AbstractAluminum (Al) and polyvinylidene fluoride (PVDF) composites can be used in many unique applications in the field of energetic materials. Due to their low melting point, many PVDF composites can be additively manufactured. However, more research is needed to better understand the ignition and combustion of these materials. Manipulating the size of aluminum (Al) particles in Al/PVDF composites can drastically alter the burning rate, ignition characteristics, and possibly flame temperatures. This study characterizes the ignition of additively manufactured micro‐ and nano‐ Al/PVDF composites through hotwire ignition tests. Both nAl and μAl particles were mixed in PVDF at 20 wt.% and additively manufactured into disks via fused filament fabrication. The nAl/PVDF printed disks ignited at a minimum ignition power (MIP) of 4.1 W compared to the 9.5 W required for ignition of μAl/PVDF disks. At identical powers, ignition delays were significantly shorter for nAl/PVDF disks. Additionally, while the nAl/PVDF disks reacted instantaneously at any power above their MIP, the μAl/PVDF disks exhibited smaller, localized flames before complete combustion, if the power was below 17.5 W. Flame temperatures were estimated through three‐color pyrometry and compared to thermochemical equilibrium calculations. While theoretical flame temperatures for nAl/PVDF and μAl/PVDF are 2023 K and 2314 K respectively, both samples burned near 2000 K when measured using pyrometry.
The effect of saffron (Crocus sativus L.) on glycemia, lipid profile, and antioxidant status in patients with type‐2 diabetes mellitus: A randomized placebo‐controlled trial
Authors: Tajaddini Aynaz , Roshanravan Neda , Mobasseri Majid , Haleem Al‐qaim Zahraa , Hadi Amir , Aeinehchi Aydin , Sefid‐Mooye Azar Pouria , Ostadrahimi Alireza 
Published: December 2022

AbstractIn the current study, we aimed to investigate the effect of saffron supplementation on glycemic status, lipid profile, atherogenic indices, and oxidative status in patients with type‐2 diabetes (T2DM). In a randomized, double‐blind controlled trial, 70 patients were randomly allocated into two groups (n = 35, each) and received 100 mg/day of saffron or placebo for eight weeks. Dietary intake, weight, body mass index (BMI), waist and hip circumferences (WC and HC), waist to hip ratio (WHR), fasting blood sugar (FBS), hemoglobin A1c (HbA1c), insulin, and Homeostatic model assessment for insulin resistance (HOMA‐IR), lipid profile, atherogenic indices, oxidative status, and liver enzymes were determined before and after the intervention. At the end of the eighth week, saffron intervention could significantly reduce FBS (7.57%), lipid profile (except high‐density lipoprotein cholesterol [HDL‐C]), atherogenic indices, and liver enzymes (p < .05). Moreover, saffron could improve oxidative status (nitric oxide [NO] and malondialdehyde [MDA] reduced by 26.29% and 16.35%, respectively). Catalase (CAT) concentration remained unchanged. Saffron supplementation may alleviate T2DM by improving glycemic status, lipid profile, liver enzymes, and oxidative status. Further investigation is necessary to assess possible side effects and confirm the positive effect of saffron as a complementary therapy in clinical recommendations for T2DM.
Performance based attack detection and security analysis for cyber‐physical systems
Authors: Zhao Zhengen , Xu Yunsong 
Published: December 2022

SummaryThis paper studies attack detection and security analysis for cyber‐physical systems from the viewpoint of control performance. The performance residual generated by Bellman equation has been presented to construct the attack detector. Then, the control‐performance‐based attack detection schemes are designed for state measurable system and state unmeasurable system, respectively. Furthermore, the data‐driven realizations of control‐performance‐based attack detection are presented via kernel identification. Moreover, the security analysis of the proposed control‐performance‐based attack detection schemes is studied, in which the undetectable state and output attacks are designed. Finally, simulations on the model of a flight vehicle demonstrate the effectiveness of the proposed methods.