bluuebunny/crossref_metadata_2025_split huggingface dataset:
Abstract IA017: Anticipating, tracking, and targeting new prostate cancer lineages driven by treatment pressures
Authors: Nelson Peter S. 
Published: June 2023

Abstract
Prostate cancer is notable for the near universal dependence on signaling pathways regulated by the androgen receptor (AR). For decades, this feature has served as the major focal point for prostate cancer treatment. However, in the setting of advanced metastatic disease, AR pathway repression is not curative and treatment resistance occurs universally. Emerging mechanisms of resistance to AR-directed therapy involve changes in tumor cell phenotypes where AR-regulated differentiation programs are repressed and new lineage programs are activated. This presentation will discuss the lineage types that have been recognized in model systems and in clinical tumors, describe approaches to monitor patients for the development/emergence of new therapy-induced lineages, and discuss treatment strategies that target new characteristics and vulnerabilities that accompany these new lineages.
Citation Format: Peter S. Nelson. Anticipating, tracking, and targeting new prostate cancer lineages driven by treatment pressures [abstract]. In: Proceedings of the AACR Special Conference: Advances in Prostate Cancer Research; 2023 Mar 15-18; Denver, Colorado. Philadelphia (PA): AACR; Cancer Res 2023;83(11 Suppl):Abstract nr IA017.
SHP2 Inhibition Sensitizes Diverse Oncogene-Addicted Solid Tumors to Re-treatment with Targeted Therapy
Authors: Drilon Alexander , Sharma Manish R. , Johnson Melissa L. , Yap Timothy A. , Gadgeel Shirish , Nepert Dale , Feng Gang , Reddy Micaela B. , Harney Allison S. , Elsayed Mohamed , Cook Adam W. , Wong Christina E. , Hinklin Ronald J. , Jiang Yutong , Brown Eric N. , Neitzel Nickolas A. , Laird Ellen R. , Wu Wen-I , Singh Anurag , Wei Ping , Ching Keith A. , Gaudino John J. , Lee Patrice A. , Hartley Dylan P. , Rothenberg S. Michael 
Published: June 2023

Abstract

Rationally targeted therapies have transformed cancer treatment, but many patients develop resistance through bypass signaling pathway activation. PF-07284892 (ARRY-558) is an allosteric SHP2 inhibitor designed to overcome bypass-signaling-mediated resistance when combined with inhibitors of various oncogenic drivers. Activity in this setting was confirmed in diverse tumor models. Patients with ALK fusion–positive lung cancer, BRAFV600E-mutant colorectal cancer, KRASG12D-mutant ovarian cancer, and ROS1 fusion–positive pancreatic cancer who previously developed targeted therapy resistance were treated with PF-07284892 on the first dose level of a first-in-human clinical trial. After progression on PF-07284892 monotherapy, a novel study design allowed the addition of oncogene-directed targeted therapy that had previously failed. Combination therapy led to rapid tumor and circulating tumor DNA (ctDNA) responses and extended the duration of overall clinical benefit.

Significance:
PF-07284892–targeted therapy combinations overcame bypass-signaling-mediated resistance in a clinical setting in which neither component was active on its own. This provides proof of concept of the utility of SHP2 inhibitors in overcoming resistance to diverse targeted therapies and provides a paradigm for accelerated testing of novel drug combinations early in clinical development.
See related commentary by Hernando-Calvo and Garralda, p. 1762.
This article is highlighted in the In This Issue feature, p. 1749
Religious Conversion, Proselytization, and the Marginalisation of Indigenous Religions in Ghana
Authors: Atiemo Abamfo Ofori , Tweneboah Seth 
Published: June 2023

Abstract
This paper probes the intricate connection of conversion, proselytization, and the state of Ghana to achieve three overarching goals. First, it unravels how colonialism, Christianity, and Islam have historically and collectively marginalised African indigenous religions. Second, it demonstrates a clever state maneuver to continue the historic joint colonial and missionary projection of Christianity and Islam at the expense of other traditions. Third, it interrogates how the state of Ghana is mindful of the political implications of frustrating the principle of separation. Against these positions, the paper argues that despite tacit attempts to privilege Christianity and Islam over indigenous religion, the state of Ghana maintains a moderate secularist stance that enhances free and equal participation of its religiously diverse populations in the public space.
Church as Family: Creating Healing and Transformative Spaces for Children at Risk through a Reimagining of Ecclesiology
Authors: Pfeiffer Cara L. 
Published: June 2023

Abstract
Children growing up in contexts of toxic stress face a cascade of deleterious realities that impact them at every level of their being. However, when children are securely attached to healthy adults in their lives, those supportive relationships can be both protective and transformative for those young people. Given the power of secure attachment and the New Testament’s frequent use of the metaphor of family to describe the church, this paper proposes that when ecclesial communities operate as real and healthy families in their contexts, those communities can thereby create missiologically significant spaces of healing and transformation for the children in their midst. In an effort to reimagine and reshape our ecclesial communities to function as such reciprocal and mutually supportive families, Child Theology and studies of early Christian community, catechesis, and worship are put into conversation with one another.
Power in Context: Healing Practices in Churches in Norway and Madagascar
Authors: Kleiven Tormod , Austnaberg Hans , Austad Anne , Nygaard Marianne Rodriguez 
Published: June 2023

Abstract
The aim of this article is to investigate the power dynamics at play in open and announced healing practices in Norway and Madagascar. The main research question is: What characterizes the power dynamics at play in healing practices in Norway and Madagascar? We analyzed empirical material by using a power theoretical approach to describe the exercise of power. Through a study in two different ecclesial and cultural contexts, we indicate the (il)legality of exercising “power over” in healing practices, how the “power from” concept can be misused to justify a “power over” attitude – but can also moderate the use of this attitude – and how crucial it is to practice a relational, mutual interdependency.
Configurations of Islam in Contemporary Art in Norway
Authors: Zorgati Ragnhild Johnsrud 
Published: June 2023

Abstract
In this article, I explore how Islam is configured in two creative universes that have recently affected the cultural and political scene in Norway. I compare the enactment in Oslo (2019) of Disgraced by the American playwright Ayad Akhtar to parts of the artistic project Heisann Montebello (2015–2017) by the Norwegian rap duo Karpe. In both fictional universes, references to Islam, Muslims, xenophobia, racism, terror, and politics of integration are paramount. It is therefore significant that major cultural institutions in Norway such as The National Theater, the music hall Oslo Spektrum, the National Library, and the Norwegian Broadcasting Network (NRK) stage these works. Overall, my main argument is that both productions speak to wider audiences in a multireligious and multiethnic setting, demonstrating that Muslims and different configurations of Islam have become an integrated part of Norwegian cultural life.
Russian Orthodox Imaginaries and Their Family Resemblance to Populism
Authors: Rousselet Kathy 
Published: June 2023

Abstract
This article sets out to demonstrate how some Russian Orthodox imaginaries bear a family resemblance to populism. These imaginaries have a distinctive ideological anchor. The influential religious figures who convey them lay claim to a legacy of political thought that can be traced back to a specific form of narodnichestvo, which is Slavophile and associated with aspirations for monarchy. This investigation of populism among Russian Orthodox Christians is structured in three parts. The article begins with a presentation of an ideological repertoire that emphasizes the centrality of the idea of “the people.” Drawing on interviews and material collected over several years in different regions of Russia, particularly Yekaterinburg, the article then looks at the rebellion of Christians who feel marginalized or consider that the Russian Orthodox Church does not have enough influence in Russia. Finally, it explores how “the people” has become central to religious practice itself.
Homeless Objects
Authors: Fréchette Guillaume 
Published: June 2023

Abstract
In this article, I shed some light on Meinong’s motivations for the theory of objects. I argue that one of its basic principles, the principle of indifference, is driven by an intuition common to many Austrian philosophers, which is that something must first be somehow pre-given in order to simply address the issue of its being or non-being. Meinong’s way of spelling out this intuition, I suggest, is to show that there are homeless objects, that is, objects that are not dealt with by any of the existing sciences. Therefore, the indispensability of the theory of objects lies in the plausibility of the thesis that there are such homeless objects. I analyse and evaluate two Meinongian arguments supporting this thesis, I explain how Meinong came to believe that they support the indispensability of the theory of objects, and I stress some advantages of this account over Brentano’s intentionality thesis.
‘What the Far East Means to America’: The Politics of Area Studies during the Interwar Years
Authors: Chen Constance 
Published: June 2023

Abstract
During the interwar years, Americans redefined the meaning of Asianness amid new geopolitical conditions and shifts in global axes of power, thereby relocating the role that Asia played in the U.S. grand strategy to recalibrate the nation-state’s position within the international community. Throughout the 1920s and 1930s, a consortium of international non-governmental organizations such as the Institute of Pacific Relations and the American Council of Learned Societies collaborated with universities in the production of knowledge. Historians and international relations specialists have touted the creation of area studies at institutions of higher learning at the end of World War ii as one of the principal responses for stemming the proliferation of communism. Instead of focusing on the 1950s and 1960s as the formative era of the academic discipline as many scholars have done, this article illuminates the earlier interconnections between the nascent intellectual fascination with Asia and the reinscription of otherness. Ultimately, anxiety over growing Japanese aggression in the Pacific aided the development of U.S. hegemony as the academic system became part of an inter-imperialist amalgamation of a multitude of economic, intellectual, and political processes and mechanisms that worked together to engineer American influence within and over Asia.
Painting Restoration and the Eye of the Beholder: A Mobile Eye-Tracking Study at the Unterlinden Museum
Authors: Fontoura Pablo , Miscenà Anna , Menu Michel , Schaeffer Jean-Marie 
Published: June 2023

Abstract
Art historical literature has often discussed the impact of painting restorations on viewers. Although many theoretical hypotheses have been proposed regarding the effect of restoration on the beholder’s eye, little empirical research has addressed this topic. This study aimed to fill this gap by investigating whether painting restoration has a meaningful influence on the visual perception of art viewers at the eye-movement level. Specifically, the study designed a mobile eye-tracking study in an ecologically valid setting — the art museum — to investigate the effects of restoration on ten panels from the Isenheim Altarpiece (1512–1516) by Matthias Grünewald, currently displayed at the Unterlinden Museum in France. In this study, 86 museum visitors looked at paintings while wearing eye-tracking glasses before (n = 43) and after (n = 43) restoration. The following measures were analyzed: (1) Total Viewing Time; (2) Duration of the First Fixation; (3) Relative Fixation Count; (4) Fixation Heat Maps; (5) Time to First Fixation in areas of interest (AOIs). The results suggested that Relative Fixation Count significantly increased after restoration. Conversely, the Total Viewing Time and Duration of the First Fixation did not seem to be significantly affected by restoration. The Heat Maps suggested a broader visual inspection of the images and a more explorative gaze pattern after restoration. Moreover, the Time to First Fixation in AOIs significantly decreased after restoration. These findings provide the first empirical evidence of the impact of restoration on the visual perception of genuine paintings as opposed to reproductions observed in a museum.
The Afrocentric-Youth Paradigm
Authors: Amenyedzi Seyram B. 
Published: June 2023

Abstract
The Afrocentric-Youth Paradigm proposes a research methodology or a model for doing African youth research. Afrocentrism highlights that African research is done by African people through the actual African lens and approached from African cultural perspectives. This means that the lived cultural experiences of the African people are imperative in producing a more reliable and credible research output. On the other hand, it is normal for young people in Africa to experience discrimination and exclusion from major decision making and activities due to age. Most African cultures value the aged above young people with the assumption that they are inexperienced and therefore do not have much to offer. It is in this light that I propose that African cultures need to be interrogated holistically and thoroughly when researching on young people. The Afrocentric-Youth Paradigm is a proposed research methodology that provides specific questions that need to be addressed in the culture while doing African youth research.
Analysis of Clinical Outcomes After Robotic Hepatectomy Applying the Western-Model Southampton Laparoscopic Difficulty Scoring System. An Experience From a Tertiary US Hepatobiliary Center
Authors: Sucandy Iswanto , Kang Richard D. , Adorno Jeilianis , Godwin Sarah , Crespo Kaitlyn , Syblis Cameron , Ross Sharona , Rosemurgy Alexander 
Published: June 2023

Background Identification of resections with high risk of intraoperative complications is critical in guiding case selection for minimally invasive liver surgery. Several Japanese and European difficulty scoring systems have been proposed for laparoscopic liver surgery. However, the applicability of these systems for robotic liver resections has not been fully investigated. This study considers the Southampton system and examines its validity when applied to robotic hepatectomies. Methods We undertook a retrospective review of 372 patients who underwent robotic hepatectomies for various indications between 2013 and 2022. Of these patients, 63 operations were classified as low risk, 91 as moderate risk, 198 as high risk and 20 as extremely high risk based on Southampton criteria. Patient outcomes were compared by utilizing an ANOVA of repeated measures. Data are presented as median (mean ± SD) Results The Southampton difficulty scoring system was a strong predictor of intraoperative variables including tumor size, operative duration, estimated blood loss (EBL), and incidence of major vs minor resection (all P < .0001). In contrast, the Southampton system was a weaker predictor of postoperative outcomes including 30-day mortality ( P = .15), length of stay ( P = .13), and readmissions within 30 days ( P = .38). Conclusion The Southampton difficulty scoring system is a valid system for classifying robotic liver resections and is a strong predictor of intraoperative outcomes. However, the system was found to be a weaker predictor of postoperative outcomes. This finding may suggest the need for proposal of a new difficulty scoring system for robotic hepatectomies.
Association of Laparoscopic Approach With Improved Short-Term Outcomes in Patients With Hematologic Malignancy Undergoing Splenectomy
Authors: Balan Naveen , deVirgilio Christian M. , Ozao-Choy Junko , Moazzez Ashkan 
Published: June 2023

Background Patients with hematologic malignancies undergo splenectomy for both diagnostic and therapeutic purposes. Although minimally invasive surgery continues to be increasingly utilized for a variety of abdominal operations, no large-scale data has compared the postoperative outcomes for laparoscopic vs open splenectomy in patients with hematologic malignancy. Methods Patients with a diagnosis of hematologic malignancy who underwent laparoscopic and open splenectomy between 2015 and 2020 were queried using the ACS-NSQIP database. 30-day outcomes of laparoscopic vs open splenectomy were compared. Results Out of 430 patients included in the study, 52.6% were male, with a mean age of 63.4 ± 13.1 years. 233 patients (54.2%) underwent laparoscopic splenectomy. On bivariate analysis, laparoscopic surgery was associated with lower rates of 30-day mortality [2.1% vs 11.7% ( P < .001)] and morbidity [9.0% vs 24.4% ( P < .001)]. On multivariate regression, elective operations (OR .255, 95%CI: 0.084-.778, P = .016) and laparoscopic surgery (OR .239, 95%CI: 0.075-.760, P = .015) were independently associated with lower mortality, while history of metastatic cancer (OR 3.331, 95%CI: 1.144-9.699, P = .027) was associated with higher mortality. Laparoscopic surgery (OR .401, 95%CI: 0.209-.770, P = .006) and steroid use (OR 2.714, 95%CI: 1.279-5.757, P = .009) were the only two factors independently associated with 30-day morbidity. Laparoscopic surgery was also associated with shorter hospital length of stay (median 3 [IQR:3] vs 6 [IQR:7] days). Conclusion Laparoscopic splenectomy was associated with lower 30-day mortality and morbidity, and shorter length of stay in patients with hematologic malignancies. These data suggest that laparoscopic approach, when feasible, may be preferred for splenectomy in this patient population.
Implementation of AIRVO™ System for Postoperative Tracheostomy Care in Head and Neck Free Flaps
Authors: Masood Maheer M. , Yu Katherine , Penn Denice , Ramirez Janine , Michaels Amanda , Shnayder Yelizaveta 
Published: June 2023

Objective: Effective postoperative tracheostomy management after free flap surgery is critical but can offer challenges including difficulty with humidification delivery and contraindications toward neck instrumentation. The purpose of this project was to establish a multidisciplinary team and implement the AIRVO™ tracheostomy humidification system for those undergoing free flap surgery and determine its effect on respiratory secretions and related events. Methods: A retrospective cohort study of head and neck free flap surgery patients prior to implementation of AIRVO™ (Jan 2021-May 2021) and after (August 2021-December 2021) were analyzed with a 2 month (June 2021-July 2021) implementation phase. Main variables analyzed included excessive tracheal secretions, necessity of supplemental oxygen above baseline for a day or greater, respiratory rapid response calls, elevation to intensive care units (ICU), and length of hospital stay. Results: A total of 82 patients (40 pre-AIRVO™ and 42 with AIRVO™) met criteria for the study. A significant reduction in excessive tracheal secretions (40% pre-AIRVO™, 11.9% with AIRVO ™, P = .01) and necessity of supplemental oxygen above baseline (25% pre-AIRVO™, 7.1% with AIRVO ™, P = .04) were observed. No significant difference in hospital length of stay ( P = .63) was observed. No respiratory rapid responses or elevation to ICU care were seen in either groups. Conclusion: The AIRVO™ system provided an efficient, portable, free of neck instrumentation, and easy to use device that resulted in a reduction in excessive tracheal secretion events and necessity of supplemental oxygenation needs in free flap tracheostomy patients
Development and refinement of a corner-based injury prevention programme for Latino day labourers
Authors: Springer Andrew E , King Yesmel , Field Craig , Ojeda Martha Alicia , Brown Louis , Monforton Celeste , Hernandez Rodrigo , Diamond Pamela , Atkinson John , Fernández-Esquer Maria Eugenia 
Published: June 2023

Objective: Latino day labourers (LDLs) in the USA are at increased risk for non-fatal and fatal occupational injuries, which are compounded by stressors that include wage theft, job insecurity and discrimination. This paper describes the development and refinement of Vales+Tú (You are Worthy of More), an injury prevention programme currently being evaluated as part of a cluster randomised trial in which health promotion is taken directly to the ‘corners’ (e.g. street corners, home improvement store parking lots, and public parks) where workers gather to seek employment. Design: Vales+Tú comprises two corner-based intervention approaches, group problem-solving (small group discussions) and brief motivational interviewing (one-on-one dialogue), that aim to activate LDL agency to control their safety and that of their peers. Setting: Corners in Houston, Texas, where LDLs seek employment. Method: Intervention Mapping informed the refinement of Vales+Tú for the current trial. We provide a narrative review of the development process based on needs assessment and formative development activities (surveys, focus group discussions and pilot tests). Results: In addition to documenting the need for LDL injury prevention, with 20.2%–41.6% of Houston-based LDLs surveyed between 2013–2014 and 2019 reporting a severe work-related injury in the past year, we describe key facets of the Vales+Tú corner-based intervention approaches – including their theoretical basis and LDL-centred activities, as well as enhancements made informed by formative evaluation. Conclusion: The community-engaged development process of Vales+Tú resulted in two practical intervention approaches that can be adopted by worker centres and other organisations to promote LDL worker safety.