bluuebunny/crossref_metadata_2025_split huggingface dataset:
The risk of breast cancer is associated with rs1800872 genetic variation. A cohort study
Authors: Bahmani Banafsheh , Behjati Mohaddeseh , Iravani Maliheh Sadat , Masoomi Mona , Haddadi Azadeh , Matini Amir Hasan , Nejati Majid 
Published: September 2023

Abstract
Many women across the globe are afflicted with breast cancer, making it one of the most prevalent forms of the disease. Changes to single nucleotides in crucial genes may affect one's likelihood of contracting the illness. This study was intended to see if alterations in the nucleotide sequence of one particular interleukin 10 gene, called rs1800872, could have an effect on the probability of getting breast cancer. A study was performed to look at the correlation between single nucleotide polymorphisms in the interleukin 10 gene and the occurrence of breast cancer by comparing two hundred women composed of 150 with the disease and 150 healthy controls. Genomic DNA was isolated from the study participants to identify the genotype of the samples at the rs1800872 polymorphism site. The analysis found that having one copy of the rs1800872 CA genotype and its related allele, A, increased the likelihood of breast cancer when compared against being in the heterozygous or allelic models. Furthermore, categorized analysis revealed a strong association with the size of the tumor but not with lymph node metastasis. From these results, rs1800872 polymorphism can be regarded as a potential genetic risk factor for breast cancer.
Monthly runoff prediction of the lower Yellow River based on the VMD-SSA-KELM model
Authors: Zhang Xianqi , Liu Jiawen , Ren He 
Published: September 2023

Abstract
Guiding the efficient utilization of water resources relies on a high-precision prediction of monthly runoff in the lower reaches of the Yellow River. disaster prevention and mitigation, water environmental protection, and ecological restoration. Based on the superior performance of VMD in processing non-stationary monthly runoff sequences, the multimodal optimization ability of SSA in the direction of data sequences, and the advantageous features of KELM model KELM model efficiency, tuning free, and memory friendliness, a monthly runoff prediction model for the lower Yellow River was established using the VMD-SSA-KELM coupling method, and apply the coupled model to predict the monthly runoff at Lijin Hydrological Station in Downstream Areas. The results indicate that the model has a reasonable predictive effect on the monthly runoff data of this hydrological station; it has high accuracy compared with the traditional prediction model, and the R2 of the prediction model for Lijin Hydrological Station reaches 0.97, with an average absolute error of 8.02, an average absolute percentage error of 0.44, and a root mean square error of 37.25; at the same time, the model can effectively extract the inherent feature information of the corresponding time series, improving the prediction performance of runoff data, it can make the monthly runoff forecast more accurate.
Efficacy of 14-day vonoprazan-amoxicillin dual therapy compared to esomeprazole-amoxicillin dual therapy for eradication of Helicobacter pylori in treatment-naïve patients
Authors: Wang Rui , Xian Feng , Zhu Jian-ru , Peng Jian , Wu Ding-jian , Zhang Feng , Bi Xian-jin , Liu Heng-qi , Liu Hao , Hu Jie , Lan Chun-hui 
Published: September 2023

Abstract
Objective: This study was a multicenter, randomized controlled trial that compared the therapeutic efficacies of vonoprazan-amoxicillin (VA) and esomeprazole-amoxicillin (EA) dual therapies for Helicobacter pyloriinfection in China.
Methods: A total of 236 patients were randomized to receive either VA dual therapy (vonoprazan 20 mg bid, amoxicillin 1 g tid, 14 days) or EA dual therapy (esomeprazole 20 mg qid, amoxicillin 750 mg qid, 14 days). The success of eradication was assessed using a 13C urea breath test after 4-6 weeks. The study assessed H. pylori eradication rates, incidence of adverse reactions, patient compliance, antibiotic resistance rates, and CYP2C19 gene polymorphisms.
Results: Both the intention-to-treat (ITT) analysis and the per-protocol (PP) analysis demonstrated that the eradication rate by the VA group (ITT:96.61%, 95%CI 93.34–99.88%; PP:98.26%, 95% CI 95.87–100.00%)was not inferior to that of the EA group (ITT:93.22%,88.68-97.76%; PP:93.10%, 95% CI 90.80-98.86%) with the one-sided P < 0.0001 for both. The incidence of adverse reactions was 11.30% and 13.79% for the two groups (P=0.568), and compliance rates were 97.46% and 98.3% for the VA and EA groups, respectively, with both exceeding 95% (P = 1.000). Compliance was identified as an independent risk factor for H. pylori eradication (P= 0.002).
Conclusions: The 14-day VA and EA dual therapies have comparable efficacies and safeties, and both are recommended as first-line treatment for an H. pylori infection.
Sensommatic: An efficient pipeline to mine and predict sensory receptor genes in the era of reference-quality genomes.
Authors: Ryan Louise , Lawless Colleen , Hughes Graham M. 
Published: September 2023

Abstract
Sensory receptor gene families have undergone extensive expansion and loss across vertebrate evolution, leading to significant variation in receptor counts between species. However, due to their species-specific nature, conventional reference-based annotation tools often underestimate the true number of sensory receptors in a given species. While there has been an exponential increase in the taxonomic diversity of publicly available genome assemblies in recent years, only ~30% of vertebrate species on the NCBI database are currently annotated. To overcome these limitations, we developed ‘Sensommatic’, an automated and accessible sensory receptor annotation pipeline. Sensommatic implements BLAST and AUGUSTUS to mine and predict sensory receptor genes from whole genome assemblies, adopting a one-to-many gene mapping approach. While designed for vertebrates, Sensommatic can be extended to run on non-vertebrate species by generating customised reference files, making it a scalable and generalizable tool.
Early identification of postoperative remission for thyrotropin-secreting adenomas
Authors: Fan Linling , Wang Zhihong , Sun Wanwan , Cui Qiaoli , Wu Wei , Xiang Boni , Ma Zengyi , Wu Yue , Wang Yongfei , Zhao Yao , Zhang Zhaoyun , Li Yiming , He Min , Ye Hongying 
Published: September 2023

Abstract
Purpose
Thyrotropin-secreting adenoma (TSHoma) is a rare type of pituitary adenoma, occurring in one per million people. Little is known about TSHoma. We summarized the demographic, clinical and hormonal characteristics of TSHoma based on a single-center experience. Moreover, we explored the predictive value of postoperative thyroid function for long-term remission.
Methods
We retrospectively analyzed 63 patients who were diagnosed as TSHoma and surgically treated at our hospital from January 2015 to June 2021. The preoperative clinical characteristics were analyzed and compared between remission and nonremission groups. Thyroid function was measured at 1 day, 1 month, 3 months, 6 months, 12 months and over 12 months after surgery to determine whether they could predict long-term remission.
Results
The male to female ratio for TSHoma was 1.25. The mean age at diagnosis was 45 ± 12 years. Clinical presentation was varied, presenting with hyperthyroidism (68.25%), space-occupying effect (15.87%), amenorrhea (7.14% of female patients) and nonsymptoms (22.22%). 88.14% of patients achieved postoperative endocrinological remission. Larger tumor size and tumor invasion into cavernous sinus and suprasellar with chiasmal compression were strong predictors of lower rates of endocrinological remission. Postoperative thyroid function at 3 months was a viable diagnostic predictor for postoperative remission, especially for FT4 level with a 20.65pmol/L cutoff.
Conclusions
Tumor size and extent are major prognostic factors for remission. Postoperative thyroid function at 3 months could be used as a clinical prediction tool for long-term endocrinological remission
Drought forecasting using W-ARIMA model with standardized precipitation index
Authors: Rezaiy Reza , Shabri Ani 
Published: September 2023

Abstract

Climate change and water supply shortages are paramount global concerns. Drought, a complex and often underestimated phenomenon, profoundly affects various aspects of human life. Thus, early drought forecasting is crucial for strategic planning and water resource management. This study introduces a novel hybrid model, combining wavelet transform with the Autoregressive Integrated Moving Average (ARIMA) model, known as Wavelet ARIMA (W-ARIMA), to enhance drought prediction accuracy. We meticulously analyze monthly precipitation data from January 1970 to December 2019 in Kabul, Afghanistan, focusing on multiple time scales (SPI 3, SPI 6, SPI 9, SPI 12). Comparative assessment against the conventional ARIMA approach reveals the superior performance of our W-ARIMA model. Key statistical indicators, including Root Mean Squared Error (RMSE), Mean Absolute Error (MAE), and Mean Absolute Percentage Error (MAPE), underscore the improvements achieved by the W-ARIMA model, notably in SPI 12 forecasting. Additionally, we evaluate performance using metrics like R-square, NSE, PBIAS, and KGE, consistently demonstrating the W-ARIMA model's superiority. This substantial enhancement highlights the innovative model's clear superiority in drought forecasting for Kabul, Afghanistan. Our research underscores the critical significance of this hybrid model in addressing the challenges posed by drought within the broader context of climate change and water resource management.
Household level wastewater management and disposal data collection in the U.S.: the history, shortcomings, and future policy implications
Authors: Maxcy-Brown Jillian , Elliott Mark A. , Bearden Bennett 
Published: September 2023

Abstract

Country-level sanitation access is monitored globally by the Joint Monitoring Programme (JMP). However, recent reports on sanitation access in high-income countries indicate that the JMP data may underestimate the prevalence of unsafely managed sanitation in these settings. This study explains the surveys that collect household-level wastewater management data in the U.S. and analyzes the accuracy and reliability of these data sets. From 1940 to 1990, sewage disposal data were collected comprehensively through the U.S. Decennial Census. These data are currently collected through the American Housing Survey (AHS) which appears to greatly underestimate the usage of onsite wastewater treatment systems (OWTS). In addition to these surveys, we highlight current efforts to introduce a sewage disposal question to the American Community Survey (ACS), localized efforts to collect wastewater data, and the Point-in-Time count of people experiencing homelessness. Using estimates of OWTS usage in new housing, this study provides the first defensible national estimate of OWTS usage since 1990. We estimate that 25.03% of U.S. households use OWTS which exceeds the AHS estimate (15.7%) by over 12 million households. This study discusses the potential for better wastewater data collection to inform future wastewater policy and improve the quality of life for U.S. residents.
Effects of Caraway and (S)-(+)-carvone Extract on the Expression of Genes Coding Key Glycolytic Enzymes in Streptozotocin-induced Diabetic Rats
Authors: Zakeri Ramin , Noroozi-Karimabad Mojgan , Hajizadeh Mohammadreza , Wong Alexei , Zarei Sadegh , Hosseiniara Reza , Mahmoodi Mehdi 
Published: September 2023

Background:
Diabetes mellitus is a metabolic disorder causing dysfunctional regulation of carbohydrate metabolism and contributing to multiple serious health challenges worldwide.

Aims:
This research explores the effect of caraway hydroalcoholic extract and (S)-(+)-carvone on the transcription of genes coding for key glycolytic enzymes in the liver of the diabetic rat treated with streptozotocin (STZ).

Methods:
In this experimental study, diabetes was established in four groups of rats by injecting 45 mg/kg of STZ intraperitoneally. Further normal rats that were not injected formed the control group. Over four weeks, the effects of caraway hydroalcoholic extract (150 and 250 mg/kg) and carvone (100 mg/kg) were evaluated using PCR and histopathological evaluation, specifically in the form of effects on the transcription process of genes coding key glycolytic enzymes in the liver of the diabetic rats.

Results:
Over the four-week assessment period, rats’ food intake, and therefore blood glucose levels, were decreased through the daily oral administration of carvone and caraway extract (150 mg/kg) when compared to those administered with further STZ. The expression of key glycolytic enzymes, including glucokinase, pyruvate kinase, and phosphofructokinase 1 in the liver of diabetic rats was restored to near-normal levels by carvone and caraway extract, especially at the 150 mg/kg dose. Histopathological evaluation of diabetic rat liver demonstrated that administration of caraway extract and carvone decreased the STZ-induced damage to liver tissue.

Conclusion:
150 mg/kg of caraway extract strongly regulates glycolysis by regulating the gene expression of key glycolytic enzymes in diabetic rats.
Post-COVID-19 Sydenham Chorea: A Case Report
Authors: Camargo José Augusto , Morcillo Stéfani Augustoli 
Published: September 2023

Background:
Sydenham chorea, or rheumatic chorea, is a movement disorder that is more prevalent among young people, with a mean age at symptom onset between 8 and 9 years. The condition is more common in females. Sydenham chorea is associated with rheumatic fever and is considered the most common cause of acute chorea in children. We believe that the present case is worth reporting since the occurrence of Sydenham chorea as a post-COVID-19 sequela has not been described in Brazil.

Case Presentation:
We report here the case of a 14-year-old girl with symptoms of acute chorea that emerged 15 days after treatment resolution of COVID-19 (SARS-CoV-2 or severe acute respiratory syndrome coronavirus 2). Brain computed tomography (CT) and magnetic resonance imaging scans showed no changes, and the laboratory tests revealed no signs of an active infectious process. In contrast, neurological positron-emission tomography/CT showed mild glycolytic hypometabolism in the bilateral mesial frontal region. Administration of an oral anticonvulsant resulted in a marked improvement in her symptoms.

Conclusion:
Despite major efforts of the scientific community for discovering treatments, preventive methods, mechanisms of action, and possible sequelae of SARS-CoV-2, there is still a long way to go to better understand this devastating pathological agent that has affected the global population.
Cancer Risk in Elderly Korean Patients with Neurodegenerative Disease and its relation to Type 2 Diabetes
Authors: Kim Hee-Cheol , Kim Ji-Hun , Lee Ho-Jun , Kim Yang-Tae , Jang Byeong-Churl 
Published: September 2023

Introduction:
Some studies suggest that neurodegenerative diseases (NDs), cancer, and type 2 diabetes (T2D) are all related to protein misfolding and may be linked. This study aimed to determine whether these diseases are associated with each other.

Objective:
The aim of the study was to investigate the difference in cancer incidence according to the presence or absence of T2D in the ND group and the control group during the 10-year follow-up period.

Methods:
A population-based 10-year follow-up study was conducted using the Korean National Health Insurance Service Database between 2002 and 2015. The study population included the ND group (n = 9,292) and the control group (n = 46,742), who were aged 60 to 84 years. Cox proportional hazards regression was used to estimate multivariable-adjusted hazard ratios (HRs) for cancer.

Results:
ND and/or T2D were newly diagnosed in both groups during the follow-up period. The newly diagnosed ND cases before cancer onset were 2,412 (26.0%) and 15,435 (33.0%) in the ND and control groups, respectively (p < 0.01). The newly diagnosed T2D cases were 4,691 (50.5%) and 25,695 (55.0%) in the ND and control groups, respectively (p < 0.01). At the end of the observation period, the number of cancer patients was 2,040 (22.0%) and 8,628 (18.5%) in the ND and control groups, respectively (p < 0.01). The ND group was associated with an increased risk of cancer (HR = 1.25). In both groups, newly diagnosed ND and T2D showed an additive effect on cancer incidence during the follow-up period.

Conclusion:
This study showed that cancer incidence was positively associated with ND and T2D. These results show that ND, cancer, and T2D are related. More replication studies are needed to address the association between ND, cancer, and T2D.
REALIZAÇÃO DO LIVRE PLANEJAMENTO FAMILIAR DAS FAMÍLIAS ECTOGENÉTICAS MEDIANTE CONTRATO DE COPARENTALIDADE
Authors: Dos Reis Amaro Mylene Manfrinato , Ciscto Yoshioka Anara Rebeca , Galdino Cardin Valéria Silva 
Published: September 2023

O artigo busca avaliar se as novas configurações familiares trouxeram desafios ao Direito a partir das famílias coparentais ectogenéticas. O problema que orienta a pesquisa pode ser sintetizado na seguinte pergunta: em que medida um simples contrato de coparentalidade pode ser considerado válido e eficaz para gerar efeitos jurídicos no planejamento familiar de famílias coparentais ectogenéticas? Com base nos dados levantados a partir de um conjunto de pesquisas realizadas sobre o tema na área do Direito, refletidas na bibliografia que dá sustentação ao presente estudo, torna-se possível afirmar que a falta de regulamentação jurídica do tema pode ser um empecilho para a aceitação desse contrato na reprodução humana assistida. O objetivo geral do texto consiste em avaliar a eficácia jurídica do contrato de coparentalidade para gerar efeitos jurídicos como o registro da parentalidade da criança e outras disposições para a efetivação do livre planejamento familiar e constituição de uma família ectogenética. Os objetivos específicos do texto, que se refletem na sua estrutura em três seções, são: a) ponderar a realização da dignidade da pessoa humana mediante o princípio do livre planejamento familiar e da pluralidade das entidades familiares; b) verificar a eficácia jurídica e os requisitos do contrato de coparentalidade diante do Direito Civil brasileiro; c) analisar as técnicas de reprodução humana assistida perante a Resolução 2.294/2021, do CFM e a possibilidade de formação de famílias coparentais ectogenéticas mediante contrato. O método de pesquisa utilizado foi o hipotético-dedutivo, mediante e emprego da técnica de pesquisa bibliográfica e documental.
Novel stability conditions for some generalization of Nicholson's blowflies model with stochastic perturbations
Authors: Shaikhet Leonid , Abbas Syed 
Published: September 2023

We consider a generalization of the well-known nonlinear Nicholson blowflies model with stochastic perturbations. Stability in probability of the positive equilibrium of the considered equation is studied. Two types of stability conditions: delay-dependent and delay-independent conditions are obtained, using the method of Lyapunov functionals and the method of linear matrix inequalities. The obtained results are illustrated by numerical simulations by means of some examples. The results are new, and complement the existing ones.

doi: 10.1017/S1446181123000147
Numerical simulations for largely deformed beams and rings adopting a nontensile smoothed particle hydrodynamics algorithm
Authors: Tran-Duc Thien , Meylan Michael , Thamwattana Natalie 
Published: September 2023

Three typical elastic problems, including beam bending, truss extension and compression, and two-rings collision are simulated with smoothed particle hydrodynamics (SPH) using Lagrangian and Eulerian algorithms. A contact-force model for elastic collisions and equation of state for pressure arising in colliding elastic bodies are also analytically derived. Numerical validations, on using the corresponding theoretical models, are carried out for the beam bending, truss extension and compression simulations. Numerical instabilities caused by largely deformed particle configurations in finite/large elastic deformations are analysed. The numerical experiments show that the algorithms handle small deformations well, but only the Lagrangian algorithm can handle large elastic deformations. The numerical results obtained from the Lagrangian algorithm also show a good agreement with the theoretical values.

doi: 10.1017/S1446181123000160
Exact solutions of hyperbolic reaction-diffusion equations in two dimensions
Authors: Broadbridge Phil , Goard Joanna 
Published: September 2023

Exact solutions are constructed for a class of nonlinear hyperbolic reaction-diffusion equations in two-space dimensions. Reduction of variables and subsequent solutions follow from a special nonclassical symmetry that uncovers a conditionally integrable system, equivalent to the linear Helmholtz equation. The hyperbolicity is commonly associated with a speed limit due to a delay, \(\tau\), between gradients and fluxes. With lethal boundary conditions on a circular domain wherein a species population exhibits logistic growth of Fisher–KPP type with equal time lag, the critical domain size for avoidance of extinction does not depend on \(\tau\). A diminishing exact solution within a circular domain is also constructed, when the reaction represents a weak Allee effect of Huxley type. For a combustion reaction of Arrhenius type, the only known exact solution that is finite but unbounded is extended to allow for a positive \(\tau\).

doi: 10.1017/S1446181123000093