bluuebunny/crossref_metadata_2025_split huggingface dataset:
Thermodynamic 2D Silicene for Sequential and Multistage Bone Regeneration
Authors: Ni Ni , Ge Min , Huang Rui , Zhang Dandan , Lin Han , Ju Yahan , Tang Zhimin , Gao Huiqin , Zhou Huifang , Chen Yu , Gu Ping 
Published: January 2023

AbstractBone healing is a multistage process involving the recruitment of cells, revascularization, and osteogenic differentiation, all of which are modulated in the temporal sequence to maximize cascade bone regeneration. However, insufficient osteoblast cells, poor blood supply, and limited bone induction at the site of critical‐sized bone defect broadly impede bone repair. 2D SiO2‐silicene@2,2′‐,azobis(2‐[2‐imidazolin‐2‐yl] propane) (SNSs@AIPH) with inherent thermodynamic property and osteoinductive activity is therefore designed and engineered for sequentially efficient bone repair. By means of controllable NIR‐II irradiation, the integrated SNSs@AIPH stimulates the generation of appropriate intracellular reactive oxygen species, which accelerates early bone marrow mesenchymal stem cells (BMSCs) proliferation and angiogenesis remarkably. Importantly, as silicon‐based 2D nanoparticles, the engineered SNSs@AIPH with high biocompatibility features distinct bioactivity to significantly promote BMSCs osteogenesis differentiation by activating TGFβ and BMP pathways. In a rat cranial defect model, SNSs@AIPH‐NIR‐II leads to a comparable increase of BMSCs proliferation and local vascularization at an early stage, followed by significant osteogenic differentiation, synergically resulting in a highly effective bone repair. Collectively, the fascinating characteristics and exceptional bone repair efficiency of NIR‐II‐mediated SNSs@AIPH allow it to be a promising bionic‐oriented strategy for bone regeneration, broadening a new perspective in the application of cell‐instructive biomaterials in bone tissue engineering.
Origin of the Anomalous Electrical Transport Behavior in Fe‐Intercalated Weyl Semimetal Td‐MoTe2
Authors: Wang Tianyang , Luo Xuan , Gao Jingjing , Jiang Zhongzhu , Wang Wei , Yang Xingcai , Zhou Nan , Zhu Xiaoguang , Zhang Lei , Lu Wenjian , Song Wenhai , Lv Hongyan , Sun Yuping 
Published: January 2023

AbstractWeyl semimetal Td‐MoTe2 has recently attracted much attention due to its intriguing electronic properties and potential applications in spintronics. Here, Fe‐intercalated Td‐FexMoTe2 single crystals (0 < x < 0.15 ) are grown successfully. The electrical and thermoelectric transport results consistently demonstrate that the phase transition temperature TS is gradually suppressed with increasing x. Theoretical calculation suggests that the increased energy of the Td phase, enhanced transition barrier, and more occupied bands in 1T′ phase is responsible for the suppression in TS. In addition, a ρα–lnT behavior induced by Kondo effect is observed with x ≥ 0.08, due to the coupling between conduction carriers and the local magnetic moments of intercalated Fe atoms. For Td‐Fe0.15MoTe2, a spin‐glass transition occurs at ≈10 K. The calculated band structure of Td‐Fe0.25MoTe2 shows that two flat bands exist near the Fermi level, which are mainly contributed by the dyz and orbitals of the Fe atoms. Finally, the electronic phase diagram of Td‐FexMoTe2 is established for the first time. This work provides a new route to control the structural instability and explore exotic electronic states for transition‐metal dichalcogenides.
Metal–Organic Frameworks for Water Harvesting and Concurrent Carbon Capture: A Review for Hygroscopic Materials
Authors: Lin Hengyu , Yang Yihao , Hsu Yu‐Chuan , Zhang Jiaqi , Welton Claire , Afolabi Ibukun , Loo Marshal , Zhou Hong‐Cai 
Published: January 2023

AbstractAs water scarcity becomes a pending global issue, hygroscopic materials prove a significant solution. Thus, there is a good cause following the structure–performance relationship to review the recent development of hygroscopic materials and provide inspirational insight into creative materials. Herein, traditional hygroscopic materials, crystalline frameworks, polymers, and composite materials are reviewed. The similarity in working conditions of water harvesting and carbon capture makes simultaneously addressing water shortages and reduction of greenhouse effects possible. Concurrent water harvesting and carbon capture is likely to become a future challenge. Therefore, an emphasis is laid on metal–organic frameworks (MOFs) for their excellent performance in water and CO2 adsorption, and representative role of micro‐ and mesoporous materials. Herein, the water adsorption mechanisms of MOFs are summarized, followed by a review of MOF's water stability, with a highlight on the emerging machine learning (ML) technique to predict MOF water stability and water uptake. Recent advances in the mechanistic elaboration of moisture's effects on CO2 adsorption are reviewed. This review summarizes recent advances in water–harvesting porous materials with special attention on MOFs and expects to direct researchers’ attention into the topic of concurrent water harvesting and carbon capture as a future challenge.
Compressible Polymer Composites with Enhanced Dielectric Temperature Stability
Authors: Tang Tongxiang , Yang Wenfeng , Shen Zhonghui , Wang Jian , Guo Mengfan , Xiao Yao , Ren Weibin , Ma Jing , Yu Rong , Nan Ce‐Wen , Shen Yang 
Published: January 2023

AbstractHigh‐dielectric‐constant polymer composites have broad application prospects in flexible electronics and electrostatic energy storage capacitors. Substantial enhancement in dielectric constants (εr) of polymer composites so far can only be obtained at a high loading of nanofillers, resulting in high dielectric loss and high elastic modulus of polymer composites. Addressing the polarization shielding and the consequent polarization discontinuity at polymer/filler interfaces has been a long‐standing challenge to achieve flexible polymer composite with high εr. Herein, a polymer composite with interconnected BaTiO3 (BT) ceramic scaffold is proposed and demonstrated, which exhibits a high εr of ≈210 at a low BT volume fraction of ≈18 vol%, approaching the upper limit predicted by the parallel model. By incorporating relaxor Ba(ZrxTi1−x)O3 phase in BT scaffold, dielectric temperature stability is further achieved with Δεr below ±10% within a broad temperature range (25–140 °C). Moreover, the dielectric performances remain stable under a compressive strain of up to 80%. This work provides a facile approach to construct large‐scale polymer composites with robust dielectric performance against changes in thermal and mechanical conditions, which are promising for high‐temperature applications in flexible electronics.
Unlock Restricted Capacity via OCe Hybridization for LiOxygen Batteries
Authors: Sun Zhuang , Zhao Xiaohui , Qiu Wujie , Sun Bin , Bai Fan , Liu Jianjun , Zhang Tao 
Published: January 2023

AbstractThe aprotic Li‐O2 battery (LOB) has the highest theoretical energy density of any rechargeable batteries. However, such system is largely restricted by the electrochemically formed lithium peroxide (Li2O2) on the cathode surface, leading ultimately to low actual capacities and early cell death. In contrast to the surface‐mediated growth of thin film with a thickness <50 nm, a non‐crystalline Li2O2 film with a thickness of >400 nm can be formed via an optimal OCe hybridized electronic structure. Specially, oxygen can react with dissolved cerium cations in the electrolyte via a cerium‐oxygen reaction to form a high‐energy faceted cerium oxide catalyst, which not only generates a great number of non‐saturable active sites, but also erects electron transport bridges between the lattice O and adjacent Ce atoms. Such CeO orbital hybridization also forms a direct charge transfer channel from Ce‐4f of CeO2 to ‐π* of Li2O2, eventually leading to submicron‐thick Li2O2 shells via a subsequent lithium‐oxygen reaction. Relying on the above merits, this work unlocks the rechargeable capacities of LOB from restricted 1000 to unprecedented 10 000 mAh g−1 with good cyclabilities and reduced charge–discharge overpotentials.
Intrinsically Cross‐Linked ECM‐Like Multilayers for BMP‐2 Delivery Promote Osteogenic Differentiation of Cells
Authors: Anouz Reema , Selekere Tamaradobra , Hautmann Adrian , Husteden Catharina , Menzel Matthias , Woelk Christian , Schmelzer Christian E. H. , Groth Thomas 
Published: January 2023

AbstractSurface coatings prepared by layer‐by‐layer technique permit loading of growth factors (GFs) and their spatially controlled release. Here, native chondroitin sulfate (nCS), oxidized CS (oCS100), or mixture of both (oCS50) are combined with collagen I (Col I) to fabricate polyelectrolyte multilayers (PEMs) that exhibit structural, mechanical, and biochemical cues like the natural extracellular‐matrix. The use of oCS enables intrinsic cross‐linking of PEM that offers higher stability, stiffness, and better control of bone morphogenetic protein‐2 (BMP‐2) release compared to nCS. oCS100 PEMs have enhanced stiffness, promote Col I fibrillization, and present BMP‐2 in a matrix‐bound manner. oCS50 PEMs show intermediate effects on osteogenesis, soft surface, high water content but also moderately slow BMP‐2 release profile. C2C12 myoblasts used for osteogenesis studies show that oCS PEMs are more stable and superior to nCS PEMs in supporting cell adhesion and spreading as well as in presenting BMP‐2 to the cells. oCS PEMs are triggering more osteogenesis as proved by the quantitative real‐time polymerase chain reaction, immune and histochemical staining. These findings show that intrinsic cross‐linking in oCS/Col I multilayers provides a successful tool to control GFs delivery and subsequent cell differentiation which opens new opportunities in regenerative therapies of bone and other tissues.
Enhanced Cancer Imaging and Chemo‐Photothermal Combination Therapy by Cancer‐Targeting Bismuth‐Based Nanoparticles
Authors: Bao Qing , Zhang Ying , Liu Xiangyu , Yang Tao , Yue Hui , Yang Mingying , Mao Chuanbin 
Published: January 2023

AbstractDue to the complexity and heterogeneity of cancer, the clear and accurate tumor imaging and image‐guided multimodal synergistic therapy are highly in demand. Here, bismuth (Bi)‐based mesoporous‐silica‐coated nanoparticles (BMSNs) are successfully fabricated with the silica shell thickness being lower than the Bi nanoparticle diameter. Then, an MCF‐7 breast cancer‐targeting peptide (termed AR) is modified onto the surface of BMSNs. The obtained nanoparticles (BMSN‐AR) show a significantly higher loading of doxorubicin hydrochloride (DOX). The resultant BMSN‐AR‐DOX can agglomerate in the tumor site, enabling enhanced computed tomography (CT) imaging of the whole tumor. Under 808 nm near‐infrared (NIR) laser irradiation, the BMSN‐AR‐DOX also effectively converts light energy into thermal energy to achieve synergistic chemo‐photothermal therapy in vivo. The chemo‐photothermal combination therapy is found to be more effective than chemotherapy or photothermal therapy alone. This work demonstrates that tumor‐homing peptides can guide nanoparticles to tumors and allow the nanoparticles to enhance cancer imaging and photothermal/chemo combination therapy.
Piezoelectric‐Effect Enhanced Perovskite Plasmonic Nanolasers
Authors: Li Meili , Lu Junfeng , Wan Peng , Jiang Mingming , Lin Feng , Wu Xianxin , Liu Xinfeng , Pan Caofeng 
Published: January 2023

AbstractHerein, the piezoelectric effect of CsPbBr3 perovskite is utilized for the first time to enhance the nanolasers performance based on the flexible poly(ethylenenaphthalate) PEN/single‐crystal‐Au/MgF2/CsPbBr3 (ScAu/M/CPB) structure. The dynamic‐modulated plasmonic lasing mode blueshift is achieved by the piezoelectric polarization effect (PPE)‐induced effective refractive index (neff) change by varying the applied strain (ε). In particular, taking advantage of the increased cavity mode frequency, the lasing threshold (Pth) reduces from 4.5 µJ cm−2 (ε = 0) to 1.5 µJ cm−2 (ε = −1.02%). The ε‐dependent carrier dynamics results reveal the nature of ultralow Pth being PPE‐induced spontaneous emission (SE) decay rate enhancement, leading to the reduction in radiation loss of the plasmonic cavity. The corresponding enhancement mechanism is put forward to elucidate the principle of piezoelectric‐induced dynamic modulation nanolasers characteristic. This work demonstrates that coupling of piezoelectric effect and plasmonics is an effective route to enhance the performance of plasmonic nanolasers.
A computationally‐cost effective model for fluid flow in redox flow batteries
Authors: Asadipour Erfan , Ramani Vijay K. 
Published: January 2023

AbstractRedox flow batteries (RFBs) hold great potential for large‐scale, extended‐duration stationary energy storage. Here, a novel computationally cost‐effective hydraulic‐electrical analogous model (HEAM) for fluid flow in RFBs is developed. The HEAM demonstrated that lowering the electrode compression and enhancing the channel area lowers the pump power loss independent of the flow fields and electrodes. Additionally, the HEAM helped elucidate the deficiencies of flow distribution in interdigitated flow fields (IFFs) and suggested designing wider manifolds and/or shorter channels improve the flow distribution. Moreover, the HEAM suggested shallower and/or wider channels, and more permeable electrodes enhance the flow penetration rate above the channels. Finally, the HEAM showed that the average penetration depth in the electrode above the ribs (hpen) was the critical parameter in the fluid‐flow modeling of IFFs and was inversely proportional to the permeability. Hence, there is a trade‐off between the pump power loss and hpen when configuring electrode permeability.
Polypropylene/talc/graphene nanoplates (GNP) hybrid composites: Effect of GNP content on the thermal, rheological, mechanical, and electrical properties
Authors: Sarturato Ana Carolina Prataviera , Dos Anjos Erick Gabriel Ribeiro , Marini Juliano , Morgado Guilherme Ferreira De Melo , Baldan Maurício Ribeiro , Passador Fabio Roberto 
Published: January 2023

AbstractPolypropylene (PP)/talc composites are used extensively in the automotive, aeronautical, and consumer goods industries; however, the increasing demand for more efficient, safe, and less environmentally impact materials makes it necessary to include new reinforcements. In this way, the use of graphene nanoplates (GNP) is a good alternative because this carbon‐based material allows the achievement of new multifunctional nanocomposites with improved properties and process optimization. In this work, PP/talc (80/20) composites were prepared with the addition of 1, 3, 5, and 7 wt% of GNP using the extrusion process and injection molding. Morphological, thermal, rheological, mechanical, electrical, and electromagnetic characterizations were performed. The addition of GNPs led to a linear reduction in the melt flow index (MFI) of the samples. A rheological percolation was observed in the sample with the addition of 7 wt% of GNP. The addition of 5 and 7 wt% of GNP led to significant increases in elastic modulus and Shore D hardness. The electrical and electromagnetic evaluation showed that the increase of GNP in the compositions contributed to improvements in electrical conductivity and permittivity, resulting in a proportional increment in the total attenuation component (SET).
rno‐miR‐90 promotes chondrogenic differentiation of bone marrow mesenchymal stem cells by targeting SPARC‐related modular calcium binding 2
Authors: Ouyang Xiyan , Wang Shuxian , Xie Jinqi , Kong Jiechen , Chunmei Ma , Pan Hao , Cao Jiahui , Chen Dongfeng , Liu Aijun 
Published: January 2023

AbstractBone marrow mesenchymal stem cells (BMSCs) have the ability to differentiate into chondrocytes. In the differentiation of BMSCs into chondrocytes, micro‐RNAs (miRNAs) play an important role. rno‐miR‐90 is a new miRNA discovered by our research team, and its role in chondrogenic differentiation of BMSCs is unknown. This study aimed to investigate whether rno‐miR‐90 could promote chondrogenic differentiation of BMSCs by regulating secreted protein acidic and rich in cysteine‐related modular calcium binding 2 (Smoc2). First, BMSCs chondroblast differentiation was successfully induced in vitro by classical induction method of transforming growth factor (TGF)‐β3. On this basis, we transfected rno‐miR‐90 mimic and inhibitor, and confirmed that rno‐miR‐90 mimic could promote the differentiation of BMSCs into chondrocytes by real‐time reverse transcription‐quantitative polymerase chain reaction (RT‐qPCR) and western blotting. In addition, we demonstrated that Smoc2 was a target gene of rno‐miR‐90 by dual‐luciferase reporter assay, and confirmed that rno‐miR‐90 mimic could inhibit the expression of Smoc2 by RT‐qPCR and western blotting. In order to further prove the targeting relationship between rno‐miR‐90 and Smoc2, we constructed three interfering fragments of Smoc2, and proved that silencing Smoc2 could promote the differentiation of BMSCs into chondrocytes at the transcriptional and protein levels. Finally, we constructed a carrier scaffold for ectopic chondrogenic differentiation in vivo, and confirmed that rno‐miR‐90 mimic and siSmoc2 could promote chondrogenic differentiation of BMSCs by Alcian blue staining and immunohistochemistry. In summary, our results suggested that rno‐miR‐90 could promote chondrogenic differentiation of BMSCs by down‐regulating the expression of Smoc2. rno‐miR‐90 mimic and Smoc2 may be therapeutic targets of osteoarthritis.
Antimicrobial, Antiproliferative Effects and Docking Studies of Methoxy Group Enriched Coumarin‐Chalcone Hybrids
Authors: Badreddin Musatat Ahmad , Kılıçcıoğlu İlker , Kurman Yener , Dülger Görkem , Alpay Merve , Yağcı Ravza , Atahan Alparslan , Durmuş Sefa 
Published: January 2023

AbstractMethoxy group enriched eight coumarin‐chalcone hybrid derivatives were synthesized. Antimicrobial/ antiproliferative activities were tested against eight human pathogenic microorganisms and four cancer cell lines (AGS, HepG2, MCF‐7 and PC‐3), respectively. Antimicrobial results showed that most of the compounds were almost more active than used standard antibiotics. Cytotoxicity results showed that 2,3,4‐trimethoxyphenyl and thiophene containing structures have promising antiproliferative effects against AGS gastric cell lines with ∼5 μg/ml IC50 values. At the same time, 2,4‐dimethoxyphenyl bearing derivative exhibited the lowest IC50 values against HepG2 (∼10 μg/ml) and PC‐3 (∼5 μg/ml) cell lines. Particularly, the cell viabilities of MCF‐7 cell lines were remarkably inhibited by all the compounds with lower IC50 values. Therefore, molecular docking studies between hybrid ligands and quinone reductase‐2 enzyme (regulates in MCF‐7 cancer cells) were performed. The results demonstrated that all the derivatives can smoothly interact with interested enzyme in agreement with the experimental results. Finally, ADME parameters were studied to reveal drug‐likeness potentials of the coumarin‐chalcone hybrids.
Common variable immunodeficiency with granulomatous‐lymphocytic interstitial lung disease treated with monoclonal antibodies against COVID‐19: A case report
Authors: Lechner Christian , Zöggeler Thomas , Bellmann Romuald , Brunner Jürgen , Zlamy Manuela , Schirmer Michael 
Published: January 2023

AbstractCommon variable immunodeficiency (CVID) is the most prevalent primary immunodeficiency. We present a 22‐year‐old Caucasian woman with CVID and granulomatous lymphocytic interstitial lung disease who contracted COVID‐19 and was successfully treated with sotrovimab and molnupiravir. This treatment may have contributed to the relatively mild disease course of COVID‐19 in our patient.
Modeling and Validation Studies on Solidification of Sodium Nitrate and LiCl‐KCl
Authors: Sujish Divakaran , Joseph Joby , Mythili Manoharan , Muralidharan B. , Ponraju D. 
Published: January 2023

AbstractTernary alloy fuel will be used as driver fuel for future fast reactors. Reprocessing of this spent alloy fuels will be carried out by pyrochemical reprocessing which is based on molten salt electrorefining at high temperature. During electrorefining, fission products get accumulated in the electrolyte along with some actinides in the form of their chlorides. The presence of fission products in the salt will add to the radioactivity levels and hence have to be stripped off. Melt crystallization is pursued to remove fission products from contaminated salt and to reuse the purified salt for electrorefining. Numerical modeling and experimental studies on tracking the phases during solidification of molten sodium nitrate salt were carried out. The numerical predictions closely matched with the experimental results. A resistance measurement technique was developed to accurately track the solidification interface so as to validate the numerical predictions.
Possible role of the collagen type I alpha 1–platelet‐derived growth factor beta chain fusion gene in the development of dermatofibrosarcoma protuberans with fibrosarcomatous transformation
Authors: Katsumata Fuminori , Kamiya Koji , Miyauchi Hitomi , Okada Hirofumi , Sato Atsuko , Maekawa Takeo , Komine Mayumi , Ohtsuki Mamitaro 
Published: January 2023

AbstractDermatofibrosarcoma protuberans with fibrosarcomatous transformation (DFSP‐FS) is a rare variant, with higher rates of recurrence and metastasis than DFSP. Detection of the collagen type I alpha 1 (COL1A1)–platelet‐derived growth factor beta chain (PDGFB) fusion gene is useful for the diagnosis of DFSP. In this letter, we report a case of DFSP‐FS, focusing on the expression of the COL1A1‐PDGFB fusion gene in the lesions. Increased expression of the COL1A1‐PDGFB fusion gene may be associated with fibrosarcomatous changes during the pathogenesis of DFSP.
Polyhedral oligomeric silsesquioxane‐based functional coatings: A review
Authors: Zhang Kaka , Huang Shuaishuai , Zhang Qi , Zhu He , Zhu Shiping 
Published: January 2023

AbstractPolyhedral oligomeric silsesquioxane (POSS)‐based coatings have attracted significant attention from academia and industry over the past decades. The three‐dimensional nano‐sized cage with alternating SiO bonds forms the inorganic core of POSS molecules, while organic functional groups are covalently attached to the Si vertices. With this unique structure, they can be integrated with polymers via different approaches, including physical blending, covalent grafting, and chemical cross‐linking. And the inorganic/organic hybrid nature of POSS offers the coating materials with desirable mechanical, anti‐wetting, anti‐corrosive, icephobic, and fire‐retardant properties. This review focuses on the state‐of‐the‐art developments of POSS‐based functional coatings, while their challenges and future research directions are also discussed.