bluuebunny/crossref_metadata_2025_split huggingface dataset:
Focused navigation for respiratory–motion‐corrected free‐running radial 4D flow MRI
Authors: Falcão Mariana B. L. , Rossi Giulia M. C. , Rutz Tobias , Prša Milan , Tenisch Estelle , Ma Liliana , Weiss Elizabeth K. , Baraboo Justin J. , Yerly Jérôme , Markl Michael , Stuber Matthias , Roy Christopher W. 
Published: March 2023

PurposeTo validate a respiratory motion correction method called focused navigation (fNAV) for free‐running radial whole‐heart 4D flow MRI.MethodsUsing fNAV, respiratory signals derived from radial readouts are converted into three orthogonal displacements, which are then used to correct respiratory motion in 4D flow datasets. Hundred 4D flow acquisitions were simulated with non‐rigid respiratory motion and used for validation. The difference between generated and fNAV displacement coefficients was calculated. Vessel area and flow measurements from 4D flow reconstructions with (fNAV) and without (uncorrected) motion correction were compared to the motion‐free ground‐truth. In 25 patients, the same measurements were compared between fNAV 4D flow, 2D flow, navigator‐gated Cartesian 4D flow, and uncorrected 4D flow datasets.ResultsFor simulated data, the average difference between generated and fNAV displacement coefficients was 0.04 0.32 mm and 0.31 0.35 mm in the x and y directions, respectively. In the z direction, this difference was region‐dependent (0.02 0.51 mm up to 5.85 3.41 mm). For all measurements (vessel area, net volume, and peak flow), the average difference from ground truth was higher for uncorrected 4D flow datasets (0.32 0.11 cm2, 11.1 3.5 mL, and 22.3 6.0 mL/s) than for fNAV 4D flow datasets (0.10 0.03 cm2, 2.6 0.7 mL, and 5.1 .9 mL/s, p < 0.05). In vivo, average vessel area measurements were 4.92 2.95 cm2, 5.06 2.64 cm2, 4.87 2.57 cm2, 4.87 2.69 cm2, for 2D flow and fNAV, navigator‐gated and uncorrected 4D flow datasets, respectively. In the ascending aorta, all 4D flow datasets except for the fNAV reconstruction had significantly different vessel area measurements from 2D flow. Overall, 2D flow datasets demonstrated the strongest correlation to fNAV 4D flow for both net volume (r2 = 0.92) and peak flow (r2 = 0.94), followed by navigator‐gated 4D flow (r2 = 0.83 and r2 = 0.86, respectively), and uncorrected 4D flow (r2 = 0.69 and r2 = 0.86, respectively).ConclusionfNAV corrected respiratory motion in vitro and in vivo, resulting in fNAV 4D flow measurements that are comparable to those derived from 2D flow and navigator‐gated Cartesian 4D flow datasets, with improvements over those from uncorrected 4D flow.
Toxicity of Copper Sulfate to Largemouth Bass Fry in Naturally Soft Water
Authors: Straus David L. , Ledbetter Cynthia K. , Farmer Bradley D. , Deshotel Michael B. , Heikes David L. 
Published: March 2023

Abstract
The use of copper sulfate pentahydrate (herein, designated CuSO4) for fungus control on fish embryos is extremely effective and economical for farmers in waters with moderate or high alkalinity/hardness; however, fry toxicity in low alkalinity/hardness waters is a concern. The present study determined the acute toxicity of CuSO4 to Largemouth Bass Micropterus salmoides in naturally soft water (42 mg/L alkalinity [as CaCO3], 41 mg/L hardness [as CaCO3]). Median lethal concentration (LC50) values at 24 h were 3.97 mg/L CuSO4 for yolk-sac fry and 5.24 mg/L CuSO4 for swim-up fry. Most importantly for farmers, the no observed effect concentration (NOEC; the highest concentration tested to not cause fry mortality) was 0.625 mg/L CuSO4 for both stages of fry. Regarding the safe use of CuSO4 for fungus control on Largemouth Bass embryos, this research was done to demonstrate CuSO4 toxicity to Largemouth Bass fry in soft water.
The impact of distance education on readmission of patients with heart failure: A systematic review and meta‐analysis
Authors: Ramtin Sarina , Yazdani Zahra , Tanha Kiarash , Negarandeh Reza 
Published: March 2023

AbstractAimTo estimate the effect size of distance education on the readmission of patients with heart failure.DesignThis study was a systematic review and meta‐analysis.MethodBoth Persian and English interventional studies focused on investigating the effectiveness of any form of distance education interventions on the readmission of patients with heart failure were retrieved from the main databases: Embase, PubMed, Scopus, Web of Science, SID, and Google Scholar. Two independent teams screened the articles for eligibility. The Cochrane Risk of bias tool was implemented to evaluate the studies' quality. A random‐effects model was applied to pool the effect sizes, I2 was calculated to examine heterogeneity, and Meta‐regression was used to investigate the source of heterogeneity. The proposal was registered in the PROSPERO database (no. CRD42020187453).ResultsArticles 8836 were retrieved, and 11 articles were selected. Nine studies investigated the effect of distance education on readmission with <12‐month follow‐up (RR: 0.78 [95% CI 0.67–0.92]) and the I2 of 0.00%; and four studies examined the effect of distance intervention on readmission with 12‐month or more follow‐up (RR: 0.89 [95% CI 0.73–1.09]) and the I2 of 71.59%.
Prevalent use and evolution of exonic regulatory sequences in the human genome
Authors: Chen Jing , Ni Pengyu , Wu Siwen , Niu Meng , Guo Jun‐tao , Su Zhengsheng 
Published: March 2023

AbstractIt has long been known that exons can serve as cis‐regulatory sequences, such as enhancers. However, the prevalence of such dual‐use of exons and how they evolve remain elusive. Based on our recently predicted, highly accurate large sets of cis‐regulatory module candidates (CRMCs) and non‐CRMCs in the human genome, we find that exonic transcription factor binding sites (TFBSs) occupy at least a third of the total exon lengths, and 96.7% of genes have exonic TFBSs. Both A/T and C/G in exonic TFBSs are more likely under evolutionary constraints than those in non‐CRMC exons. Exonic TFBSs in codons tend to encode loops rather than more critical helices and strands in protein structures, while exonic TFBSs in untranslated regions (UTRs) tend to avoid positions where known UTR‐related functions are located. Moreover, active exonic TFBSs tend to be in close physical proximity to distal promoters whose genes have elevated transcription levels. These results suggest that exonic TFBSs might be more prevalent than originally thought and likely in dual‐use. We proposed a parsimonious model that well explains the observed evolutionary behaviors of exonic TFBS as well as how a stretch of codons evolve into a TFBS.Key points
There are more exonic regulatory sequences in the human genome than originally thought.
Exonic transcription factor binding sites are more likely under negative selection or positive selection than counterpart nonregulatory sequences.
Exonic transcription factor binding sites tend to be located in genome sequences that encode less critical loops in protein structures, or in less critical parts in 5′ and 3′ untranslated regions.
Infiltration monitoring using carbon nanotube buckypaper for the characterization of out‐of‐plane unsaturated permeability
Authors: Zhang Jiaxing , Zhang Wei , Wang Shaokai , Xing Fei , Gu Yizhuo , Wang Yanjie , Li Min 
Published: March 2023

AbstractThis paper developed an out‐of‐plane permeability measuring method by utilizing conductive carbon nanotube (CNT) buckypaper and its piezoresistivity. A series of CNT sensors was arranged orderly in different interlaminar regions to achieve infiltration monitoring for both glass and carbon fabrics. The response of electrical resistance to flow front was investigated, and the out‐of‐plane unsaturated permeabilities at different fiber volume fractions were further calculated according to the monitoring results of those CNT sensors. The results show that the electrical resistance variation and time curves can be divided into three stages, including the initial baseline stage, rapid growth stage, and smooth growth stage. For most CNT sensors, ΔR/R0 becomes higher than 15% and 20% at the end of rapid growth stage and smooth growth stage, respectively. These CNT sensors show the sudden increase of electrical resistance successively along the infiltration direction. The squared infiltration distance and time show linear relationship, and the out‐of‐plane unsaturated permeability is further calculated based on Darcy's law. The out‐of‐plane unsaturated permeability of EW100 glass fabric is measured to be 4.76 × 10−13 m2 at a fiber volume faction of 63.0%. The unsaturated permeability increases with decreasing fiber volume fraction, and the carbon fabric with smaller fiber diameter shows smaller unsaturated permeability at the approximate fiber volume fraction.
Associations between antidepressant use patterns during pregnancy and birth outcomes among periconception antidepressant users
Authors: Nance Nerissa , Badon Sylvia E. , Ridout Kathryn , Ahern Jennifer , Li De‐Kun , Quesenberry Charles , Avalos Lyndsay A. 
Published: March 2023

AbstractBackgroundLittle is known about antidepressant medication use patterns during pregnancy among periconception (before and immediately following conception) users. Additionally, the associations between these patterns and birth outcomes is unclear, after taking into account underlying depression severity.ObjectiveThis study describes patterns of antidepressant use among periconception users and examines associations between usage patterns and birth outcomes.Study DesignThis retrospective cohort study included pregnant Kaiser Permanente Northern California (KPNC) members with a live birth between 2014 and 2017 and an antidepressant medication fill that overlapped the 8th week of pregnancy. Outcomes were preterm birth and neonatal intensive care unit (NICU) admission. Data were extracted from KPNC's electronic health records. Modified Poisson regression was conducted.ResultsOf the 3637 pregnancies meeting inclusion criteria, 33% (n = 1204) continued antidepressant use throughout the pregnancy (refilled throughout pregnancy), 47% (n = 1721) discontinued use (no refills), and 20% (n = 712) stopped and reinitiated use (refill after 30+ day gap in supply). Women who continued use had 1.86 (95% confidence interval (CI) 1.53, 2.27) times the risk of preterm birth and 1.76 (95% CI: 1.42, 2.19) times the risk of NICU admission, compared to women who discontinued use during pregnancy. Similarly, women with continued use had 1.66 (95% CI: 1.27, 2.18) times the risk of preterm birth and 1.85 (95% CI: 1.39, 2.46) times the risk of NICU admission, compared to women who stopped and reinitiated use. This relationship held when examining continuous exposure; the relationship between continuous exposure and preterm delivery was stronger in later trimesters.ConclusionsPericonception antidepressant users who continue use during pregnancy, particularly into the second and third trimesters, may be at higher risk of adverse birth outcomes. This evidence should be considered alongside the risks associated with depression relapse.
A complex role of Arabidopsis CDKD;3 in meiotic progression and cytokinesis
Authors: Tanasa Sorin , Shukla Neha , Cairo Albert , Ganji Ranjani S. , Mikulková Pavlina , Valuchova Sona , Raxwal Vivek K. , Capitao Claudio , Schnittger Arp , Zdráhal Zbyněk , Riha Karel 
Published: March 2023

AbstractMeiosis is a specialized cell division that halves the number of chromosomes in two consecutive rounds of chromosome segregation. In angiosperm plants is meiosis followed by mitotic divisions to form rudimentary haploid gametophytes. In Arabidopsis, termination of meiosis and transition to gametophytic development are governed by TDM1 and SMG7 that mediate inhibition of translation. Mutants deficient in this mechanism do not form tetrads but instead undergo multiple cycles of aberrant nuclear divisions that are likely caused by the failure to downregulate cyclin dependent kinases during meiotic exit. A suppressor screen to identify genes that contribute to meiotic exit uncovered a mutation in cyclin‐dependent kinase D;3 (CDKD;3) that alleviates meiotic defects in smg7 deficient plants. The CDKD;3 deficiency prevents aberrant meiotic divisions observed in smg7 mutants or delays their onset after initiation of cytokinesis, which permits formation of functional microspores. Although CDKD;3 acts as an activator of cyclin‐dependent kinase A;1 (CDKA;1), the main cyclin dependent kinase that regulates meiosis, cdkd;3 mutation appears to promote meiotic exit independently of CDKA;1. Furthermore, analysis of CDKD;3 interactome revealed enrichment for proteins implicated in cytokinesis, suggesting a more complex function of CDKD;3 in cell cycle regulation.
An investigation to understand the correlation between the experimental and density functional theory calculations of noscapine
Authors: Yadav Sandeep , Sewariya Shubham , Chandra Ramesh , Singh Prashant , Kumar Ajay , Jain Pallavi , Sachdeva Shallu , Kumari Kamlesh 
Published: March 2023

AbstractNoscapine has anti‐cancerous properties as it ceases cell division at metaphase stage. It is popular for it's anti‐antitussive properties. Various derivatives of noscapine have significant potential to act as a anticancerous ability than the parent molecule. As noscapine has low toxicity, high bioactivity and good availability, it is being explored extensively. Poor solubility of noscapine has somewhat restricted the use of noscapine. Therefore, authors aim to study the nature of noscapine in different solvents using computational methods or theoretically. Density functional theory (DFT) calculations and time‐dependent density functional theory (TD‐DFT) calculations were performed to explore the electronic structure, infrared spectrum, nuclear magnetic resonance spectrum and ultraviolet‐visible spectrum of noscapine. In dimethyl sulfoxide (DMSO), noscapine had a minimum or least free energy of −8.99 × 105 kcal/mol and a maximum dipole moment of 4.183 debye (D), followed by 2.942 D in chloroform. Physiochemical descriptors indicated that noscapine would interact with other molecules when DMSO or chloroform are taken as a solvent, as its polarizability and acidic character is more in DMSO and chloroform. The ability of noscapine to consume free radicles is also predicted to increase in DMSO. A red shift was observed when noscapine was taken in polar solvents as the energy gap between the highest occupied molecular orbital (HOMO) and the lowest unoccupied molecular orbital (LUMO) was reduced. The authors also performed linear regression analysis on infrared and carbon‐13 nuclear magnetic resonance (13C‐NMR) spectra obtained from computational and experimental methods to check the correlation in their results.
Bayesian optimal phase II designs with dual‐criterion decision making
Authors: Zhao Yujie , Li Daniel , Liu Rong , Yuan Ying 
Published: March 2023

AbstractThe conventional phase II trial design paradigm is to make the go/no‐go decision based on the hypothesis testing framework. Statistical significance itself alone, however, may not be sufficient to establish that the drug is clinically effective enough to warrant confirmatory phase III trials. We propose the Bayesian optimal phase II trial design with dual‐criterion decision making (BOP2‐DC), which incorporates both statistical significance and clinical relevance into decision making. Based on the posterior probability that the treatment effect reaches the lower reference value (statistical significance) and the clinically meaningful value (clinical significance), BOP2‐DC allows for go/consider/no‐go decisions, rather than a binary go/no‐go decision. BOP2‐DC is highly flexible and accommodates various types of endpoints, including binary, continuous, time‐to‐event, multiple, and coprimary endpoints, in single‐arm and randomized trials. The decision rule of BOP2‐DC is optimized to maximize the probability of a go decision when the treatment is effective or minimize the expected sample size when the treatment is futile. Simulation studies show that the BOP2‐DC design yields desirable operating characteristics. The software to implement BOP2‐DC is freely available at www.trialdesign.org.
Effects of gypenoside L‐containingGynostemma pentaphyllumextract on fatigue and physical performance: A double‐blind, placebo‐controlled, randomized trial
Authors: Ahn Yejin , Lee Hee‐Seok , Lee Seok‐Hee , Joa Kyung‐Lim , Lim Cho Young , Ahn Yu Jin , Suh Hyung Joo , Park Sung‐Soo , Hong Ki‐Bae 
Published: March 2023

AbstractThis study was conducted to investigate the effect ofGynostemma pentaphyllumextract containing gypenoside L (GPE) on improving the cognitive aspects of fatigue and performance of the motor system. One hundred healthy Korean adults aged 19–60 years were randomized to the treatment (GPE for 12 weeks) and control groups, and efficacy and safety‐related parameters were compared between the two groups. Maximal oxygen consumption (VO2max) and O2pulse were significantly higher in the treatment group than in the control group (p = 0.007 andp = 0.047, respectively). After 12 weeks, the treatment group showed significant changes such as decreases in the levels of free fatty acids (p = 0.042). In addition, there were significant differences in the rating of perceived exertion (RPE) (p < 0.05) and value of temporal fatigue between the treatment and control groups on the multidimensional fatigue scale (p < 0.05). Moreover, the level of endothelial nitric oxide synthase (eNOS) in the blood was significantly higher in the treatment group than in the control group (p = 0.047). In summary, oral administration of GPE has a positive effect on resistance to exercise‐induced physical and mental fatigue.
Does industry 5.0 model optimize sustainable performance of Agri‐enterprises? Real‐time investigation from the realm of stakeholder theory and domain
Authors: Guo Long , Sun Dongsheng , Warraich Muhammad Akib , Waheed Abdul 
Published: March 2023

AbstractThe research on Industry 5.0 (i5.0) is relatively new and emerging therefore professionals are still striving to reveal its influence globally. This study investigates the impact of industry 5.0 to comprehend the insights into how it optimizes the sustainable performance (STP) within three core streams, that is, economic, environmental, and social perspectives from the realm of stakeholder theory within the Chinese agricultural industry. The results stated that i5.0 positively affects the STP of Agri‐enterprises. The empirical testing additionally affirmed the positive nexus of i5.0 practices toward each dimension of STP such as social, environmental, and economic perspectives based on structural equation modeling. First, it found that i5.0 has a positive correlation with the economic perspective. Second, the findings affirmed the positive linkage between i5.0 and the social perspective. Finally, the study indicated a significant correlation between i5.0 and the environmental perspective. This study provides real‐time empirical evidence for the management of Agri‐enterprises regarding i5.0 and insights into the embodiment of such capabilities to optimize enterprise STP by incorporating i5.0 model. This study presents several theoretical and managerial enrichments for Agri‐enterprises along with future avenues for the researchers to test the i5.0 capabilities toward rest of the sectors across the world.
Mass‐Independent Moisture Percentage Measurements of Flour Using Amplitude Attenuation and Phase Shift Correlation
Authors: Watabe Ken‐ichi , Kon Seitaro 
Published: March 2023

We performed mass‐independent moisture percentage measurements of flour by using a resonant cavity at 3.9 GHz. The method evaluated the straight line slope that linearly approximates the relationship between the amplitude attenuation and phase shift at a specific frequency for multiple masses of sample. Fifty types of flour with moisture percentage ranging from 9.3% to 17.4% and mass up to 0.3 g were used in this experiment. The standard error of the estimation of the calibration curve for the moisture percentage was 0.42%, which was approximately half of that of the conventional method. © 2023 Institute of Electrical Engineers of Japan. Published by Wiley Periodicals LLC.
Radiation crosslinked ethylene vinyl acetate composite with binary flame retardant: The improved performance and mechanisms
Authors: Feng Xi , Wang Zhengyu , Ma Hongli , Dang Bo , Li Jianxi 
Published: March 2023

AbstractIn this article, ethylene vinyl acetate/aluminum hydroxide/melamine cyanurate (EVA/ATH/MCA) composites were prepared by melt blending, and the crosslinking ability of EVA composites was improved by electron beam irradiation. When the ratio of ATH to MCA is 2:3, compared with the sample added with MCA only, the peak heat release rate, total heat release, and total smoke production of EVA composites are reduced by 30%, 45.9%, and 42%, respectively, and the residue content is increased to 18.1%. At the same time, CO production and CO2production are reduced, limiting oxygen index and UL‐94 are increased to 27.3% and V‐1 level. The flame‐retardant effect is significantly improved. In the combustion process, the gas generated by MCA decomposition can act as a “foaming agent,” which expands the thermal insulation layer composed of aluminum oxide and carbon residue generated by ATH decomposition, and enhances the flame‐retardant effect of condensed phase. In addition, compared with the samples before irradiation, the mechanical properties and wear resistance of EVA composites after irradiation crosslinking are improved. When the addition ratio of ATH and MCA is 2:3, the maximum tensile strength can reach 16.5 MPa.
Vorkommen ausgewählter persistenter und mobiler organischer Spurenstoffe in Oberflächengewässern Niedersachsens
Authors: Scheurer Marco , Nödler Karsten , Schmid Rebekka , Schaffer Mario 
Published: March 2023

ZusammenfassungPersistente, mobile und gegebenenfalls toxische sowie sehr persistente und sehr mobile Verbindungen – zusammengefasst unter dem Begriff PMT/vPvM‐Stoffe – stehen dank grundlegender Weiterentwicklungen der analytischen Möglichkeiten in den letzten Jahren verstärkt im Fokus der Wasser‐ und Umweltforschung. Werden belastete Oberflächengewässer als Trinkwasserressource genutzt, können diese Verbindungen aufgrund ihrer intrinsischen Stoffeigenschaften die verschiedenen natürlichen und gegebenenfalls sogar technischen Barrieren der Trinkwasseraufbereitung überwinden und somit ein potenzielles Problem für die Trinkwasserversorgung darstellen.Ziel des hier vorgestellten Projekts war es, eine nachweisstarke Analytik für die Bestimmung einer Vielzahl von PMT/vPvM‐Stoffen zu entwickeln und ein landesweites Monitoring auf diese Stoffe an niedersächsischen Oberflächengewässern durchzuführen.Die erzielten Bestimmungsgrenzen der beiden entwickelten Analysemethoden lagen mit Ausnahme von Cyanursäure (0,7 μg/L) für alle Verbindungen im ein‐ bis zweistelligen ng/L‐Bereich. Von den insgesamt 22 im Untersuchungsumfang enthaltenen Stoffen (ohne Carbamazepin, dieses wurde als Abwassertracer in den Analyseumfang aufgenommen) wurden sechs in mindestens der Hälfte aller Proben nachgewiesen. Diese waren die Arzneimittelmetaboliten Torasemid‐Carbonsäure (93 % aller Proben, bis 1,2 μg/L), Losartansäure (52 %, bis 0,30 μg/L) und Ramiprilat (51 %, bis 0,22 μg/L), der Arzneistoff Torasemid (55 %, bis 0,11 μg/L), der UV‐Stabilisator Ensulizol (83 %, bis 2,3 μg/L) sowie der Vulkanisationsbeschleuniger 1,3‐Diphenylguanidin (71 %, bis 0,16 μg/L). Die höchste individuelle Konzentration wurde für Cyanursäure beobachtet (49 μg/L).