bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perinatal Blood Gas and Acid‐Base Status of Caesarean‐derived Calves
Authors: Szenci O. , Taverne M. A. M. 
Published: December 2022

SummaryBlood gas and acid‐base status of 44 Caesarean‐derived calves (all in anterior presentation) were determined in blood samples obtained before the onset of extraction and after it. Calves were assigned to one of three groups according to their blood pH value: group 1 = normal, pH above 7.2; group 2 = slightly acidotic, pH 7.2 to 7.0; group 3 = severely acidotic, pH below 7.0. Before the onset of extraction (i.e. 4 to 5 hours after the appearance and spontaneous rupture of foetal membranes), 28 calves (63.6%) had normal acid‐base values, 10 (22.7%) had slight acidosis, and 6 (13.7%) had severe acidosis. Vigorous leg movements during extraction direct attention to the occurrence of severe acidosis. At birth the three groups of calves showed the following distribution: 22 (50%) were normal, 15 (34.1 %) had slight acidosis, and 7 (15.9%) had severe acidosis. The acid‐base balance of calves during extraction was mainly shifted to respiratory acidosis. During the first ten minutes after birth a tendency towards metabolic acidosis was observed. After ten minutes spontaneous normalization of respiratory and metabolic acidosis took place but the significant differences among the groups remained unchanged until 60 minutes after birth.
The price of reputation: Executive compensation of sin companies
Authors: Chen Sheng‐Syan , Shen Carl Hsin‐han , Wang Yanzhi 
Published: December 2022

AbstractThis study examines how and why managers receive pay premiums when vulnerable to social reputation loss. We define sin companies as those operating in the alcohol, gambling and tobacco industries. We show that company managers receive a higher asymmetric pay‐for‐performance sensitivity in their pay in addition to receiving higher total compensation. In other words, their pay increases with firm performance at a faster rate than that of their non‐sin company peers. This finding is consistent with our prediction that sin companies provide greater rewards to their managers upon satisfactory performance, generating a pay premium. We propose two explanations for the reputation pay premium associated with sin‐industry managers: the limited future career opportunities and the difficulty of reconciling managers’ self‐identity with the employer's social identity. We find stronger support for the latter explanation. The sin‐industry pay premium is larger when managers have pro‐social and religious tendencies. However, we do not find a smaller pay premium when managers are close to their retirement. Since the career concern should be reduced for managers who are near retirement, this finding is inconsistent with the career opportunity explanation. Overall, our findings are consistent with the notion that managers associate their self‐image with employers’ social identities.
Inflammation moderates the effects of lifestyle modification on neurocognition among individuals with resistant hypertension
Authors: Avorgbedor Forgive , Blumenthal James A. , Hinderliter Alan , Ingle Krista , Lin Pao‐Hwa , Craighead Linda , Tyson Crystal , Kraus William , Sherwood Andrew , Smith Patrick J. 
Published: December 2022

AbstractIndividuals with resistant hypertension (RH) have the greatest risk of cerebrovascular disease and cognitive impairment among individuals with hypertension. Elevated levels of pro‐inflammatory cytokines may represent a critical yet unexamined factor influencing the impact of healthy lifestyle changes on cognitive function. We explored the influence of inflammation on changes in cognition following lifestyle modification among individuals with RH participating in the TRIUMPH clinical trial. One hundred forty participants with RH completed a battery of neurocognitive tests along with the inflammatory marker C‐reactive protein (hsCRP) and were subsequently randomized to an intensive 4‐month lifestyle modification intervention or to education and physician advice control. Results indicated that the effects of lifestyle modification on Executive Function and Learning were moderated by pre‐intervention hsCRP levels (P = .049), with treatment efficacy increasing across levels of baseline inflammation levels (low: d = 0.12; mild: d = 0.43; moderate: d = 0.81). We conclude that inflammatory profiles may help identify individuals more likely to improve executive functioning resulting from lifestyle modification.
Circular RNA CircSLC8A1 contributes to osteogenic differentiation in hBMSCs via CircSLC8A1/miR‐144‐3p/RUNX1 in periprosthetic osteolysis
Authors: Yang Boning , Qin Yu , Zhang Ao , Wang Penghao , Jiang Hua , Shi Yunyi , You Guanchao , Shen Dianlin , Ni Shenghui , Guo Lei , Liu Ying 
Published: December 2022

AbstractCircular RNAs (circRNAs) are often found in eukaryocyte and have a role in the pathogenesis of a variety of human disorders. Our related research has shown the differential expression of circRNAs in periprosthetic osteolysis (PPOL). However, the involvement of circRNAs in the exact process is yet unknown. CircSLC8A1 expression was evaluated in clinical samples and human bone marrow mesenchymal stem cells (hBMSCs) in this investigation using quantitative real‐time PCR. In vitro and in vivo studies were conducted to explicate its functional role and pathway. We demonstrated CircSLC8A1 is involved in PPOL using gain‐ and loss‐of‐function methods. The association of CircSLC8A1 and miR‐144‐3p, along with miR‐144‐3p and RUNX1, was predicted using bioinformatics. RNA pull‐down and luciferase assays confirmed it. The impact of CircSLC8A1 in the PPOL‐mouse model was also investigated using adeno‐associated virus. CircSLC8A1 was found to be downregulated in PPOL patients' periprosthetic tissues. Overexpression of CircSLC8A1 promoted osteogenic differentiation (OD) and inhibited apoptosis of hBMSCs in vitro. The osteogenic markers of RUNX1, osteopontin (OPN) and osteocalcin (OCN) were significantly upregulated in hBMSCs after miR‐144‐3p inhibitor was transferred. Mechanistic analysis demonstrated that CircSLC8A1 directly bound to miR‐144‐3p and participated in PPOL through the miR‐144‐3p/RUNX1 pathway in hBMSCs. Micro‐CT and quantitative analysis showed that CircSLC8A1 markedly inhibited PPOL, and osteogenic markers (RUNX1, OPN and OCN) were significantly increased (P<0.05) in the mice model. Our findings prove that CircSLC8A1 exerted a regulatory role in promoting osteogenic differentiation in hBMSCs, and CircSLC8A1/miR‐144‐3p/RUNX1 pathway may provide a potential target for prevention of PPOL.
Glucose‐dependent insulinotropic polypeptide and glucagon‐like peptide‐1 secretion in humans: Characteristics and regulation
Authors: Alsalim Wathik , Lindgren Ola , Ahrén Bo 
Published: December 2022

AbstractAims/IntroductionGlucose‐dependent insulinotropic polypeptide (GIP) and glucagon‐like peptide‐1 (GLP‐1) are important incretin hormones. They are released from the gut after meal ingestion and potentiate glucose‐stimulated insulin secretion. Their release after meal ingestion and oral glucose are well established and have been characterized previously. During recent years, knowledge of other regulatory aspects that potentially may affect GIP and GLP‐1 secretion after meal ingestion have also begun to emerge. Here, the results of human studies on these novel aspects of meal‐ and nutrient‐stimulated incretin hormone secretion are reviewed.Materials and MethodsThe human literature was revisited by identifying articles in PubMed using key words GIP, GLP‐1, secretion, meal, and nutrients.ResultsThe results show that all macronutrients individually stimulate GIP and GLP‐1 secretion. However, there was no synergistic action when given in combination. A pre‐load 30 min before a meal augments the GIP and GLP‐1 response. GIP and GLP‐1 secretion have a diurnal variation with a higher response to an identical meal in the morning than in the afternoon. There is no difference in GIP and GLP‐1 secretion whether a meal is ingested slowly or rapidly. GIP and GLP‐1 secretion after dinner are the same whether or not breakfast and lunch have been ingested. The temperature of the food may be of importance for the incretin hormone response.ConclusionsThese novel findings have increased our knowledge on the regulation of the complexity of the incretin system and are also important knowledge when designing future studies.
Effects of dietary supplementation with bioactive peptides derived from rapeseed protein on the growth performance, serum biochemistry and faecal micro‐organism composition of weaned piglets
Authors: Zhong Xiaoxia , Lin Peiwen , Yao Yanchu , Liu Zhiyun , Zhou Xiaorong , Guan Xiaofeng , Huang Jinxiu 
Published: December 2022

AbstractThe present study investigated the effects of supplementing bioactive peptides derived from rapeseed protein (rapeseed peptide, Rsp) on the growth performance, serum biochemistry and faecal micro‐organism composition of weaned piglets. Sixty Duroc × Landrace × Yorkshire weaned piglets of similar weights were randomly divided into three groups. The control group (NC) was fed a basal diet, and the two treatment groups, Rsp‐1 and Rsp‐2, were fed a basal diet supplemented with 1% or 2% Rsp, respectively, for 28 days. Each treatment consisted of five replicates with four piglets per replicate. The results showed that Rsp treatment significantly improved the average daily gain and had a better feed‐to‐gain ratio (p < 0.05). The diarrhoea incidence and indices of Rsp‐1 and Rsp‐2 groups were significantly lower than the NC group (p < 0.05), and the effect of Rsp‐2 on reducing the incidence of diarrhoea was significantly higher than that of Rsp‐1 (p < 0.05). The serum albumin, serum immunoglobulin A and catalase levels of the Rsp‐1 and Rsp‐2 groups were significantly better than the NC group (p < 0.05). Additionally, Rsp treatment significantly gained the relative abundance of faecal Lactobacillaceae and decreased the relative abundance of faecal Eubacterium_coprostanoligenes_group, Treponema and Coprococcus (p < 0.05). In summary, Rsp supplementation improved the growth performance, ameliorated the diarrhoea, enhanced the immune and antioxidant functions and changed the composition of faecal micro‐organisms in piglets. These findings indicate that Rsp positively affected the health of weaned piglets.
Cold stress‐induced bladder overactivity in type 2 diabetic mellitus rats is mitigated by the combination of aM3‐muscarinic antagonist and a β3‐adrenergic agonist
Authors: Hara Hiroaki , Imamura Tetsuya , Suzuki Ataru , Ueno Manabu , Minagawa Tomonori , Ogawa Teruyuki , Ishizuka Osamu 
Published: December 2022

AbstractObjectivesGoto‐Kakizaki (GK) rats with type 2 diabetes mellitus respond to low temperature (LT) environments with bladder overactivity, including increased voiding frequency and decreased voiding interval and micturition volume. We determined if bladder overactivity could be inhibited by treatment with the combination of a M3‐muscarinic receptor antagonist and a β3‐adrenergic receptor agonist.MethodsTen‐week‐old female GK rats were fed a high‐fat diet for 4 weeks. Cystometric investigations were conducted at room temperature (RT, 27 ± 2°C). The rats were then intraperitoneally administered the vehicle,the M3‐muscarinic receptor antagonist solifenacin, the β3‐adrenergic agonist mirabegron, or a combination of solifenacin and mirabegron. Ten minutes after the administrations, the rats were transferred to the LT environment (4 ± 2°C), where the cystometric measurements were continued. The expressions of both M3‐muscarinic and β3‐adrenergic receptors were investigated.ResultsAfter transfer from RT to LT, both voiding interval and bladder capacity of the vehicle‐, solifenacin‐, or mirabegron‐treated rats were significantly decreased. However, the combination of solifenacin and mirabegron significantly mitigated the bladder overactivity. While both M3‐muscarinic and β3‐adrenergic receptors were detected, the expression of M3‐muscarinic receptor mRNA was significantly higher than that of β3‐adrenergic receptor mRNA.ConclusionsThe cold stress‐induced bladder overactivity was not improved by either the M3‐muscarinic receptor antagonist or the β3‐adrenergic receptor agonist alone. However, the combined treatment mitigated the cold stress responses. Combined therapy with M3‐muscarinic antagonists and β3‐adrenergic agonists could reduce side effects and improve the quality of life for diabetic patients with bladder overactivity.
Channeling Voices to Improve L2 English Intelligibility
Authors: LASCOTTE DARREN K. , TARONE ELAINE 
Published: December 2022

AbstractIn commercial materials for the teaching of second language (L2) pronunciation, common bottom‐up approaches segment phonology into a series of discrete and decontextualized linguistic components with rules that students are encouraged to internalize. Such approaches seem out of step with recent second language acquisition (SLA) theory and research that emphasize the central influence of social context, interlocutor, empathy, and nonverbal elements on the meaningful use of L2 forms. Research showing that these factors profoundly influence the pronunciation of an L2 in social discourse suggests a more top‐down, holistic pedagogy to better harness the agentive energy of motivated and goal‐oriented L2 learners. Drawing on findings in interlanguage phonology and Bakhtinian sociocultural theory, this article documents ways that 7 adult L2 learners in an intensive English program improved their English intelligibility, while some of them also improved their delivery, as they all mirrored and subsequently channeled the voices of model speakers in rehearsed oral presentations over the course of a short 7‐week pedagogical treatment. The findings of this study support the view that the construct of voice and the influence of social contextual factors in SLA are critical in shaping interlanguage phonology and raise a number of important pedagogical implications for addressing learning outcomes in L2 pronunciation.
Hyperviscosity syndrome complicating immunoglobulin G myeloma—Cognisance of early plasmapheresis is crucial
Authors: Vivek Sood , Kundan Mishra , Rajat Bahl , Gaurav Singhal , Manu Dogra , Suman Pramanik , Singh Vishal 
Published: December 2022

AbstractHyperviscosity syndrome (HVS) is an infrequent but life‐threatening complication of multiple myeloma (MM) and classically presents with the triad of mucosal bleed, neurological, and visual disturbances. HVS is typically associated with immunoglobulin M (IgM) MM and very rarely may complicate immunoglobulin G (IgG) MM. Even suspicion of HVS necessitates therapy based on clinical severity rather than the calculated degree of viscosity. While plasmapheresis promptly decreases serum viscosity by 30% to 50%, early initiation of anti‐myeloma therapy is crucial to prevent rebound phenomena. In this context, we report a case of IgG MM, which despite being complicated by HVS had gratifying outcome attributable to early clinical suspicion and consequent prompt therapeutic intervention.
Longitudinal trajectories of maternal parenting stress in Korean families: Children's executive function and school adjustment
Authors: Park SuJung , Oh Wonjung , Kim Yunhee , Kim Hyoun K. , Mastergeorge Ann M. 
Published: December 2022

AbstractA majority of mothers experience parenting stress in daily life; however high levels of maternal stress have been recognized as a risk factor for children's developmental outcomes. We examined trajectories of maternal parenting stress across childhood, and their longitudinal relations to children's executive function and school adjustment. Data were drawn from the Panel Study on Korean Children (PSKC), which included 1754 mothers across five waves measured at children ages 3, 4, 5, 6, and 7 (boys = 51%). Results of Latent Growth Curve Modeling (LGCM) revealed that, on average, maternal parenting stress decreased over time, but there were significant variabilities in the initial levels at age 3 and changes across early through middle childhood. High initial levels of stress and an increase in maternal parenting stress over time were associated with lower executive function at age 7 in planning‐organizing and attention concentration. An increment in maternal parenting stress over time was related to poorer school adjustment at age 7, measured by classroom behavior, positive approach to learning, and child‐peer and child‐teacher relationships. These findings support cultural commonality and may contribute to the instantiation of culturally universal, early preventions and interventions to support mothers’ mental health. Efforts aimed at reducing maternal parenting stress early in development may promote better long‐term developmental outcomes, including executive functioning and school adjustment of children in their first year of elementary school.
Evaluation of a new connected portable camera for the analysis of skin microrelief and the assessment of the effect of skin moisturisers
Authors: Gougeon Sarah , Hernandez Elsa , Chevrot Nathalie , Vergne Thibault , Cherel Marie , Prestat‐Marquis Elodie , Jomier Matthieu , Burty‐Valin Elodie 
Published: December 2022

AbstractBackgroundSilicone replicas and non‐contact methods are effective methods to analyse the micrometric scale of the skin microrelief. Yet, they imply data capture in research facilities. The capabilities of a new connected portable camera were evaluated to analyse microrelief under nomadic conditions, also studying the effect of moisturisers.Materials and methods3D depth maps were constructed using shape‐from‐shading algorithms. Roughness heterogeneity (Spa) was computed, and skin profiles were extracted to calculate roughness amplitude (Ra, Rq), as well as furrows/plateaus characteristics. Validation of the connected camera was performed on tanned cowhide leather and on the inner forearm skin of a single subject. The forearms of 18 subjects (23–60 years old) were also evaluated. While living their regular life, they self‐performed triplicate acquisitions at various times. The effects of a placebo and of cream containing moisturisers—saccharide isomerate, urea or xylitylglucoside–anhydroxylitol–xylitol—were investigated, using untreated control skin as a reference.ResultsValidation of the device on leather and forearm skin shows high repeatability. The 18 subjects show the known correlation between age and changes in microrelief. While testing formulas, 8 h after a single application, all decreased Spa (−1.6/−2.1 folds). Only saccharide isomerate and xylitylglucoside–anhydroxylitol–xylitol decreased Ra (−2.4/−2.8 folds). The sectional area of plateaus was reduced from −1.5 (urea) to −2.1 folds (xylitylglucoside–anhydroxylitol–xylitol). The height of plateaus is also decreased by all moisturisers, from −1.5 (urea) to −2.1 folds (xylitylglucoside–anhydroxylitol–xylitol).ConclusionThis novel camera device enables microrelief analysis under nomadic conditions, allowing monitoring its changes along the day and upon moisturisers’ application.
Retrieval barriers in individual participant data reviews with network meta-analysis
Authors: Veroniki Areti Angeliki , Stewart Lesley A , Le Susan P C , Clarke Mike , Tricco Andrea C , Straus Sharon E 
Published: December 2022

ObjectivesIndividual participant data (IPD) from randomised controlled trials (RCTs) can be used in network meta-analysis (NMA) to underpin patient care and are the best analyses to support the development of guidelines about the use of healthcare interventions for a specific condition. However, barriers to IPD retrieval pose a major threat. The aim of this study was to present barriers we encountered during retrieval of IPD from RCTs in two published systematic reviews with IPD-NMA.MethodsWe evaluated retrieval of IPD from RCTs for IPD-NMA in Alzheimer’s dementia and type 1 diabetes. We requested IPD from authors, industry sponsors and data repositories, and recorded IPD retrieval, reasons for IPD unavailability, and retrieval challenges.ResultsIn total, we identified 108 RCTs: 78 industry sponsored, 11 publicly sponsored and 19 with no funding information. After failing to obtain IPD from any trial authors, we requested it from industry sponsors. Seven of the 17 industry sponsors shared IPD for 12 950 participants (59%) through proprietary-specific data sharing platforms from 26 RCTs (33%). We found that lack of RCT identifiers (eg, National Clinical Trial number) and unclear data ownership were major challenges in IPD retrieval. Incomplete information in retrieved datasets was another important problem that led to exclusion of RCTs from the NMA. There were also practical challenges in obtaining IPD from or analysing it within platforms, and additional costs were incurred in accessing IPD this way.ConclusionsWe found no clear evidence of retrieval bias (where IPD availability was linked to trial findings) in either IPD-NMA, but because retrieval bias could impact NMA findings, subsequent decision-making and guideline development, this should be considered when assessing risk of bias in IPD syntheses.
UGDR: a generic pipeline to detect recombined regions in polyploid and complex hybrid yeast genomes
Authors: Bedrat Amina 
Published: December 2022

Abstract
Motivation
In eukaryotes, homologous recombination between the parental genomes frequently occurs during the evolutionary conserved process of meiosis, generating the genetic diversity transmitted by the gametes. The genome-wide determination of the frequency and location of the recombination events can now be efficiently performed by genotyping the offspring’s polymorphic markers. However, genotyping recombination in complex hybrid genomes with existing methods remains challenging because of their strain and ploidy specificity and the degree of diversity and complexity of the parental genomes, especially in $$>2n$$

>
2
n

polyploids.

Results
We present UGDR, a pipeline to genotype the polymorphisms of complex hybrid yeast genomes. It is based on optimal mapping strategies of NGS reads, comparative analyses of the allelic ratio variation and read depth coverage. We tested the UGDR pipeline with sequencing reads from recombined hybrid diploid yeast strains and various clinical strains exhibiting different degrees of ploidy. UGDR allows to plot the markers distribution and recombination profile per chromosome.

Conclusion
UGDR detects and plots recombination events in haploids and polyploid yeasts, which facilitates the discovery and understanding of the yeast genetic recombination map and identify new out-performing recombinants.