bluuebunny/crossref_metadata_2025_split huggingface dataset:
Selenium nanoparticles reduce oxidative stress-induced cardiomyocyte apoptosis in ascites syndrome in broiler chickens via the ATF6-DR5 signaling pathway
Authors: Yang Xiaoqi , Liu Xin , Liu Jiaqi , Wu Peiling , Fu Yang , Kyein San Loon , Zhang Jiabin , Zhang Mengdi , Peng Yuxuan , Zhou Donghai 
Published: July 2023

AbstractBroiler ascites syndrome (AS) is one of the main diseases threatening the health of broilers. It is well documented that myocardial hypertrophy and failure is one of the key mechanisms of broiler ascites syndrome. Therefore, prevention of cardiac hypertrophy and failure would be one goal to reduce broiler ascites syndrome incidence. Myocardial hypertrophy and failure are closely related to endoplasmic reticulum stress (ERS) in cardiac myocytes, and the endoplasmic reticulum stress signaling system (ATF6-DR5) is one of the important pathways of myocardial apoptosis. Excessive hypertrophy will affect the heart muscle’s normal contraction and diastole function, and the heart will turn from compensated to decompensate thus causing myocardial injury. Myocardial apoptosis is a core component of the pathological changes of this myocardial injury. Nano-selenium is a kind of red elemental selenium nanoparticle. Due to its excellent physical, chemical and biological properties, it has attracted extensive academic attention in recent years. It has been proven to have excellent antioxidant, antibacterial, antitumor, antihypertrophic, and antiapoptotic abilities. Herein, nano-selenium (1 µmol/L) can inhibit hydrogen peroxide (H2O2)-induced oxidative stress in broiler primary cardiomyocytes, and at the same time reduce cardiomyocyte apoptosis. In vivo, nano-selenium can reduce broiler myocardial injury-related enzyme indicators (AST, CK and LDH), and alleviate myocardial injury. It can also activate the antioxidant enzyme system (SOD, GSH-Px and CAT) and reduce MDA, and make the recovery of T-AOC ability in the organization. Meanwhile, nano-selenium can down-regulate the genes and proteins expression of ATF-6, GRP-78, CHOP and caspase 12 in the ERS-related signaling pathway, and inhibit that of downstream-related caspase 3, Bax and caspase 9, and increase that of the downstream anti-apoptotic Bcl-2, thereby maintaining the homeostasis of the endoplasmic reticulum and alleviating cardiomyocyte apoptosis. It can be seen that nano-selenium can protect the damaged myocardium in the broiler ascites caused by high-salt drinking by regulating the ATF6-DR5 signaling pathway. This study was performed in chickens and cardiomyocyte cells and attempted to demonstrate that selenium nanoparticles can protect the damaged myocardium in broiler ascites. This paper provides a new idea for preventing and treating broiler ascites syndrome.
Adrenal Venous Sampling Via an Antecubital Approach in Primary Aldosteronism: A Multicenter Study
Authors: Dong Hui , Huang Jiangnan , Zhang Ying , Dong Yifei , Liu Min , Yan Zhitao , Li Jianling , Chen Yang , Zou Yubao , Wang Jiguang , Kang Yuanyuan , Jiang Zhiyuan , Song Wei , Zuo Yujie , Xiong Hongliang , Xu Jianzhong , Jiang Xiongjing 
Published: July 2023

Abstract

Context
Adrenal venous sampling (AVS) is considered the gold standard for differentiating unilateral and bilateral forms of primary aldosteronism. Currently, almost all AVS procedures are performed via femoral vein access.

Objective
The aim of this study was to evaluate the success rate and safety of AVS via an antecubital approach.

Methods
In a retrospective multicenter study involving 7 Chinese medical centers, patients with primary aldosteronism who underwent AVS via an antecubital approach between January 2012 and December 2018 were analyzed. Successful sampling was determined by a selectivity index (cortisol in the adrenal vein/cortisol in inferior vena cava) greater than 2.

Results
A total of 1226 participants (mean age, 47.1 years; 57.9% male) were included. The puncture site was right and left antecubital vein in 1211 (98.8%), and 15 (1.2%) patients. The access of 6 patients (0.5%) was changed to right femoral vein due to the failure of antecubital vein cannulation or anatomic variation of adrenal vein. The success rate of bilateral, right, and left sampling was 91.5%, 94.9%, and 95.1%, respectively. The success rate of bilateral, right, and left sampling increased from 82.9%, 87.1%, and 88.6% during the initial 70 cases (total of initial 10 cases at each center) to 92.0% (P = .012), 95.3% (P = .008), and 95.5% (P = .018) with subsequent cases. Adrenal vein rupture occurred in 5 patients (0.41%), with no sequelae.

Conclusion
This multicenter study demonstrates that AVS via an antecubital approach is safe and feasible, with a high rate of successful sampling, which may be an alternative to the femoral vein access method.
Predporodna in poporodna obravnava žensk v Sloveniji
Authors: Jug Došler Anita , Mivšek Ana Polona , Prelec Anita , Stanek Zidarič Tita , Skubic Metka 
Published: July 2023

Uvod: V prispevku predstavljamo rezultate raziskave, s katero smo proučevali izvajanje preventivnih aktivnosti za varovanje reproduktivnega zdravja žensk v Sloveniji v predporodnem in poporodnem obdobju. Namen kvantitativne raziskave je bil proučiti pojavnost in vsebino predporodne in poporodne obravnave žensk v Sloveniji.Metode: Presečna raziskava je potekala od marca 2015 do marca 2022. Podatki so bili zbrani z anketnim vprašalnikom, na priložnostnem vzorcu 2.102 žensk. Analiza podatkov je vključevala osnovno deskriptivno statistiko z izračuni frekvenc in odstotkov. Za analizo razlik med ženskami prvorodnicami in ženskami mnogorodnicami smo uporabili Hi-kvadrat preizkus. Statistična značilnost je bila upoštevana na ravni petodstotnega tveganja.Rezultati: Raziskava je pokazala, da so v času nosečnosti obiski s strani medicinskih sester v patronažnem varstvu zelo redki (14 %). Po ocenah žensk je bila najpogosteje zastopana vsebina obiska poučevanje nosečnice o stanjih, v katerih mora ženska takoj v porodnišnico (61 %). Največ otročnic (22 %) in njihovih novorojenčkov je bilo po porodu deležnih štirih obiskov medicinskih sester v patronažnem varstvu. Ženske po porodu so bile najpogosteje deležne svetovanja s področja dojenja – prednosti dojenja in materinega mleka za otroka (79 %), medtem ko je bila obravnava novorojenčka največkrat namenjena kopanju (92 %).Diskusija in zaključek: Iz rezultatov je razvidno, da sta v slovenski praksi pojavnost in vsebina obiskov nosečnic in otročnic s strani medicinske sestre v patronažnem varstvu/babice različni. Pri pregledu otročnic so obravnave v večji meri bolj kot na otročnico osredotočene na novorojenčka, kar kaže seznam treh najpogosteje izvedenih intervencij na poporodnih obiskih: svetovanje o prednostih dojenja, položajih pri dojenju in prehrani med dojenjem.
Blood flow analysis in narrow channel with activation energy and nonlinear thermal radiation
Authors: Tanveer Anum , Abidin Zain Ul 
Published: July 2023

Abstract
Blood flow in narrow channels such as veins and arteries is the major topic of interest here. The Casson fluid with its shear-thinning attribute serves as the blood model. Owing to the arterial walls, the channel is configured curved in shape. The activation energy and nonlinear thermal radiation aspects are highlighted. The channel boundaries are flexible with peristaltic wave travelling along the channel. The mathematical description of the problem is developed under physical laws and then simplified using the lubrication technique. The obtained system is then sketched in graphs directly using the numerical scheme NDSolve in Mathematica software. The physical interpretation of parameters on axial velocity, temperature profile, concentration, and streamline pattern is discussed in the last section.
Preventing Student Suicide: Nguyen v. Massachusetts Institute of Technology
Authors: Grey Betsy J. 
Published: July 2023

Abstract
Student suicide is a tragic problem on university campuses. Should universities have a tort duty to prevent them? Common law historically has shielded universities from liability based on the “suicide rule,” which holds that suicide is an intervening cause of harm and thus not within the scope of risk of negligence. Nguyen v. Massachusetts Institute of Technology represents a shift in this view, and begins to usher universities into an era of greater accountability, while mitigating the harsh impact of the suicide rule. This essay examines Nguyen as a classic example of common law’s incremental development. As with other areas previously off-limits to tort liability, Nguyen moves cautiously, opening the door to liability but with limits that avoid expansive liability in the absence of a university’s actual knowledge of suicide risk. It is too early to tell whether those limits will remain, or whether the basis for liability recognized in Nguyen will expand. Either way, Nguyen represents an important step in tort law’s response to a significant societal problem.
Environment and Plant Use at La Tourasse (South-West France) at the Late Glacial–Holocene Transition
Authors: Liard Aurélie , Varea Carmen María Martínez , Orange François , Huot Jean-Paul , Marquebielle Benjamin , Henry Auréade 
Published: July 2023

Abstract
The aim of this study is to present new data on vegetation dynamics and plant collecting practices during the Late Glacial and the Early Holocene in southwestern France. La Tourasse cave is located in the Pyrenean piedmont plain, where the Azilian cultural complex was initially defined. The last excavations of the site took place in the 1980s and 1990s and the recovered materials are currently being studied or revisited from a multidisciplinary perspective. We present here the results of the charcoal analysis performed on La Tourasse’s Azilian (ca. 13000–11500 cal. BP) and Mesolithic (ca. 10500–9000 cal. BP) levels, complemented by the study of a small seed assemblage. Our results document the shift from an open landscape towards a forested environment, with the gradual passage from open vegetation dominated by shrubs of the Rose family (Prunus spp.) to the mixed oak forest, which speaks in favor of the biochronological coherence of this sequence. However, marked differences in taxonomic richness and state of the wood from one level to another, unrelated to the prevailing environmental conditions, suggest variable behavior of humans toward wood that could be the result of differing mobility strategies, hearth functionalities, or taxonomic preferences.
Klinefelter syndrome: a case report
Authors: Arefyeva A. N. , Volkova A. R. , Lisker A. V. , Ostroukhova E. N. , Kholudeeva T. A. 
Published: July 2023

Klinefelter syndrome (KS) is a genetic disease associated with the presence of an extra X-chromosome in the karyotype of men. The most common karyotype is 47XXY, however, other genetic variants are also possible, as well as mosaic forms.The clinical picture is most often represented by bilateral gynecomastia, decreased in the volume testicles and infertility (azoospermia). Laboratory revealed hypergonadotropic hypogonadism. Testosterone replacement therapy is used to ensure virilization and the proper quality of life. Assisted reproductive technologies with preliminary hormonal preparation are used to restore fertility.This article presents a clinical case of KS and considers options for realization of reproductive plans in the case of non-obstructive azoospermia.
Improving the quality of electricity in power supply systems with reservation from diesel generator plants
Authors: Tretyakov Evgeny A. , Meshcheryakov Alexander V. 
Published: July 2023

Subject of research: substantiation of the parameters and application of FACTS-devices of the STATCOM type for improving the quality of electricity in power supply systems with redundancy from diesel generator sets.
Purpose of research: is to substantiate technical solutions based on semiconductor devices with reactive and active power generation aimed at improving the quality of electricity in remote power supply systems powered in backup mode from diesel generator sets.
Methods and objects of research: fast Fourier transform, instantaneous power theory, simulation in Matlab Simulink. The object of research is the power supply system with a complete transformer substation 10/0.4 kV and redundancy from diesel generator sets.
Main results of research: the article presents the features of ensuring the redundancy of the considered power supply system, taking into account the quality of electricity and the rationale for technical solutions to improve it when supplying the household loads of the village in the backup mode from the DGU based on simulation modeling. A spectral analysis of a sharply variable load curve was performed. It is proposed to use a three-level STATCOM at a voltage of 0.4 kV with a supercapacitor storage, which requires less storage energy than a buffer storage, to ensure the quality of electricity when powered by a diesel generator set. The results of the studies carried out testify to the prospects of using STATCOM with a storage device to improve the quality of electricity in low-voltage networks.
Toxicity studies on intrathecal injection of low dose of DMSO used for cryopreservation of human astrocytes in mice
Authors: Sonnenfeld Tehila , Rauchbach Einat , Downey Rotem , Blumenkrants Daniel , Kuperstein Graciela , Kronfeld Noam , Margalit Raanan , Morad Vered , Nyska Abraham , Slutsky Shalom Guy , Revel Michel , Izrael Michal 
Published: July 2023

Abstract
Background
AstroRx® is an allogeneic cell therapy, composed of healthy and functional human astrocytes derived from pluripotent embryonic stem cells. An intrathecal injection of a fresh formulation of AstroRx® cells for the treatment of ALS was evaluated in an early-phase clinical trial. The results of this study indicated that the treatment is safe and showed a signal of a clinical benefit in attenuating ALS progression. Due to the logistical challenges associated with the manufacturing and distribution of a fresh cell product, a cryopreserved formulation of AstroRx® was developed. The cryopreseved AstroRx® product includes 3.5% DMSO as a cryoprotectant. Upon thawing at the clinical site, the cryopreserved product is diluted before its use to achieve a concentration of 0.23% DMSO.
Objective
To evaluate the toxicity of DMSO-containing cryopreserved AstroRx® as compared to the fresh AstroRx® following their intrathecal injection into mice.
Methods
In vitro compatibility assessment between cryopreserved and fresh AstroRx® formulations, including cell viability, cell number, cell identity, impurities, safety and potency, was performed. In addition, a neurotoxicity assessment of intrathecal injection of DMSO alone was tested in immunocompetent ICR mice using two concentrations of DMSO, 0.25% and 0.5%. The neurotoxicity of DMSO-containing cryopreserved AstroRx® product was evaluated in immunodeficient NSG mice.
Results
In-vitro comparability results demonstrated similarity between fresh AstroRx® (n = 13) and cryopreserved AsrtroRx® (n = 11) cell batches in all tested parameters. Intrathecal injection of DMSO at a concentration of 0.25% or 0.5% showed no difference, as compared to the control group, in food consumption, body weight, clinical symptoms, as well as neurological locomotor and beam tests, for 7 days post injection. Similarly, a single intrathecal injection of AstroRx® cryopreserved with DMSO following thawing or fresh AstroRx® to NSG mice was not associated with neurological signs or major systemic adverse effects during the 4- week study period. The presence of both fresh and cryopreserved AstroRx® cells at 4 weeks post injection was confirmed by Alu in-situ hybridization.
Conclusion
Pharmacokinetics, Pharmacodynamics and Bioequivalence of Test Insulin Glargine versus Reference Preparation (Lantus®) in Healthy Male Volunteers—by Euglycemic Clamp Technique
Authors: Zhang Ting , Tao Yi , Wan Lei , Zhu Mingxue , Zhang Peilin , Tang Chengyong 
Published: July 2023

Abstract
Aim
To evaluate the pharmacokinetics (PK), pharmacodynamics (PD) and bioequivalence of two insulin glargine preparations in Chinese healthy male subjects.
Methods
Randomized, open, two-sequence, four-period, single-dose, crossover design was applied in this study. A total of 40 healthy Chinese men were recruited and randomly divided into RTRT or TRTR groups. Pharmacodynamic parameters of the preparations were measured by a 24h euglycemic clamp test. Plasma insulin glargine concentration and C-peptide were collected during the trial and analyzed by high-performance liquid chromatography tandem mass spectrometry (HPLC-MS/MS) and enzyme-linked immunosorbent assay (ELISA). SAS V9.4 was used for calculation of pharmacodynamic and pharmacokinetic parameters and the equivalence of the two preparations.
Results
The average concentration of C-peptide of each sequence was lower than the baseline. PK parameters cmax of the test and the reference preparation insulin glargine were 0.580 and 0.614 ng·mL− 1, and the AUC0 − 24hwere 9.782 and 10.436 h·ng·mL− 1, respectively. PD parameters GIRmax were 42.748 and 45.279 mg·kg− 1·min− 1, AUCGIR,0−24h were 2.924 and 3.096 h·mg·kg− 1·min− 1, respectively. There was no clinically significant adverse reaction observed during the experiment.
Conclusion
The quality of the glucose clamp in this study is superior. The test insulin Glargine was bioequivalent with the reference preparation.
Investigating Arterial Stiffness in Hypertensive Individuals: Insights from Ambulatory Blood Pressure Monitoring and Correlation with Clinical and Laboratory Parameters
Authors: Tufekci Damla , Sahutoglu Tuncay , Kara Ekrem 
Published: July 2023

Abstract
Introduction
Ambulatory blood pressure monitoring (ABPM) has gained importance for its ability to measure multiple parameters and provide insights into arterial stiffness (AS). This cross-sectional study aims to investigate the relationship between aortic pulse wave velocity (PWV), 24-hour ABPM, and clinical and laboratory parameters in hypertensive individuals.
Methods
Hypertensive outpatients were enrolled in this cross-sectional study. Demographic, clinical, and laboratory data were collected, and 24-hour ABPM measurements were obtained using the Mobil-O-Graph device. Statistical analyses, including correlation tests and linear regression, were conducted to identify independent factors associated with PWV.
Results
A total of 131 participants were included. Patients with elevated blood pressure, higher body mass index, an increased number of antihypertensive agents, older age, diabetes status, higher fasting plasma glucose, elevated serum creatinine, uric acid, and proteinuria exhibited higher PWV values. Conversely, PWV showed negative correlations with estimated glomerular filtration rate and albumin levels. Systolic non-dippers exhibited increased PWV, while no such association was found in diastolic non-dippers. Pulse pressure, systolic blood pressure, diastolic blood pressure, and mean arterial pressure positively correlated with PWV. Independent determinants of PWV were identified as age, estimated glomerular filtration rate, and systolic dipping.
Conclusion
The influence of the nocturnal dipping pattern on AS varies depending on specific blood pressure components. Increased AS is associated with higher blood pressure levels, impaired renal function, advanced age, higher body mass index, and diabetes. Effective management and control of these factors linked to increased AS are crucial for reducing the risk of cardiovascular complications.
The projected changes in the surface energy budget of the CMIP5 and Euro-CORDEX models: are we heading toward wetter growing seasons in Central Europe?
Authors: Skalák Petr , Meitner Jan , Fischer Milan , Orság Matěj , Graf Alexander , Bláhová Monika , Trnka Miroslav 
Published: July 2023

Abstract
We analyze the surface energy budget from two ensembles of climate models and its future changes in the 21st century under the RCP8.5 scenario. High-resolution Euro-CORDEX regional climate models (RCMs) and their driving CMIP5 global climate models (GCMs) are first tested in Central Europe against gridded observational datasets. Evaluation reveals the added value of RCMs in terms of spatial variability and smaller biases. GCMs are affected by the positive bias of global irradiance that propagates into other radiation and heat fluxes. There are strong differences in the projected surface energy budget components between GCMs and RCMs. There is an increase in global irradiance for most of the year in GCMs that is translated into a year-round enhancement of the absorbed solar energy and balanced by higher latent heat flux, except in summer, when the sensible heat flux rises strongly. Together with strong warming and reduced precipitation in summer, this leads to warm, sunny, and dry conditions with reduced evapotranspiration and higher drought stress for vegetation. In the RCMs, the reduction in global irradiance dominates, and it is translated into a round-year reduction in the net balance of longwave radiation and stronger latent heat flux. The first months of the growing season show weaker warming associated with higher rainfall and evapotranspiration. In summer, precipitation drops, and global irradiance and warming rise, but they fall behind the changes in the GCMs. There are no visible signs of conditions leading to a reduction in evapotranspiration or a shortage of soil water in the RCMs in summer.
Non-communicable diseases, digital education and considerations for the Indian context – a scoping review
Authors: Karan Anup , Hussain Suhaib , Jensen Lasse , Buhl Alexandra , Bearman Margaret , Zodpey Sanjay 
Published: July 2023

Abstract

Introduction- The increasing ageing of population with growth in NCD burden in India has put an unprecedented pressure on India’s health care systems. Shortage of skilled human resources in health, particularly of specialists equipped to treat NCDs, is one of the major challenges faced in India. Keeping in view the shortage of healthcare professionals and the guidelines in NEP 2020, there is an urgent need for more health professionals who have received training in diagnosis, prevention, and treatment of NCDs. This paper conducts a scoping review of the published research examining digital education of health professionals within NCD topics.
Methods- We searched four databases using a three-element search string with terms related to digital education, health professions, and terms related to NCD. Data was extracted from 29 included studies that reported on empirical research into digital educational related to non-communicable disease in health professionals of India. Data were analysed thematically.
Results- The target groups were mostly in-service health professionals but there was also a considerable number of studies included pre-service students of medicine (n=6) and nursing (n=6). Among the health professionals, most were nurses (n=12), followed by medical practitioners/doctors (n=8) and other health professionals (n=8) including emergency technicians, primary care providers, medical assistants etc. While majority of the studies included were experimental or observational, randomized control trials and evaluations were also part of our study.
Discussion- Digital HPE related to NCDs has proven to be beneficial for learners and at the same time offer an effective way to bypass geographical barriers. Despite these positive attributes, digital HPE faces many challenges for its successful implementation in the Indian context. Owing to the multi-lingual and diverse health professional ecosystem in India, there is a need for strong evidence and guidelines based on prior research to Indian context.