bluuebunny/crossref_metadata_2025_split huggingface dataset:
GroEL of Porphyromonas gingivalis‐induced microRNAs accelerate tumor neovascularization by downregulating thrombomodulin expression in endothelial progenitor cells
Authors: Lin Feng‐Yen , Tsai Yi‐Ting , Huang Chun‐Yao , Lai Ze‐Hao , Tsai Chien‐Sung , Shih Chun‐Ming , Lin Cheng‐Yen , Lin Yi‐Wen 
Published: May 2023

AbstractWe found that GroEL in Porphyromonas gingivalis accelerated tumor growth and increased mortality in tumor‐bearing mice; GroEL promoted proangiogenic function, which may be the reason for promoting tumor growth. To understand the regulatory mechanisms by which GroEL increases the proangiogenic function of endothelial progenitor cells (EPCs), we explored in this study. In EPCs, MTT assay, wound‐healing assay, and tube formation assay were performed to analyze its activity. Western blot and immunoprecipitation were used to study the protein expression along with next‐generation sequencing for miRNA expression. Finally, a murine tumorigenesis animal model was used to confirm the results of in vitro. The results indicated that thrombomodulin (TM) direct interacts with PI3K/Akt to inhibit the activation of signaling pathways. When the expression of TM is decreased by GroEL stimulation, molecules in the PI3K/Akt signaling axis are released and activated, resulting in increased migration and tube formation of EPCs. In addition, GroEL inhibits TM mRNA expression by activating miR‐1248, miR‐1291, and miR‐5701. Losing the functions of miR‐1248, miR‐1291, and miR‐5701 can effectively alleviate the GroEL‐induced decrease in TM protein levels and inhibit the proangiogenic abilities of EPCs. These results were also confirmed in animal experiments. In conclusion, the intracellular domain of the TM of EPCs plays a negative regulatory role in the proangiogenic capabilities of EPCs, mainly through direct interaction between TM and PI3K/Akt to inhibit the activation of signaling pathways. The effects of GroEL on tumor growth can be reduced by inhibiting the proangiogenic properties of EPCs through the inhibition of the expression of specific miRNAs.
Deploying fetal death: “Fetal burial” laws and the necropolitics of reproduction in Indiana
Authors: Cromer Risa , Bjork‐James Sophie 
Published: May 2023

AbstractWhile abortion foes in the United States rhetorically promote “life,” discursive invocations of death are foundational to antiabortion advocacy. Pro‐life strategists have made gains mandating the mourning of aborted fetuses through fetal burial bills, which require abortion providers to cremate or bury fetal tissue from abortion procedures. Fetal burial bills are inextricably tied to biopolitical regimes that make and manage grievable life. Drawing on cultural anthropology, feminist social science, critical race theory, and long‐term research on white evangelicalism, this article examines government documents (e.g., Indiana statutes, court rulings, health reports, legislative activity, and state prosecutions) to provide a discursive critique of Indiana's fetal burial law. Constructions of aborted fetuses as grievable human life and the formations of personhood they promote undergird what anthropologist Leith Mullings called the necropolitics of reproduction—a framework explaining how reproduction is constitutive of political regimes that use systemic violence to determine who (or what) lives and dies. Legal conceptions of fetal personhood that hyper‐value fetal subjects entwine with systemic racism, Christian ideology, and anti‐environmentalism to diminish the Black and Brown bodies and environments on which their futures depend. This case is a bellwether for broader dynamics in anti‐abortion policy and activism in the post‐Roeera.
Association between poor oral health and overall mortality in palliative care patients: An analysis using time‐dependent receiver operating characteristic curves
Authors: Nakao Mifumi , Shimosato Maiko , Sakane Naoki , Nakashima Takeshi 
Published: May 2023

AbstractAimsTo determine the Oral Health Assessment Tool (OHAT) critical score in palliative care patients and the optimal timing for predicting mortality using time‐dependent receiver operating characteristic (ROC) curves.Methods and ResultsA retrospective observational study was conducted on 176 patients treated by the palliative care team of our medical center between April 2017 and March 2020. Oral health was assessed using the OHAT. Prediction accuracy was evaluated using the area under the curve (AUC) analysis, sensitivity, and specificity, using time‐dependent ROC curves. Overall survival (OS) was compared using Kaplan‐Meier curves with the log‐rank test; hazard ratios (HRs) adjusted for covariates were calculated using a Cox proportional hazard model. A OHAT score of 6 was shown to best predict 21‐day OS (AUC 0.681, sensitivity 42.2%, specificity 80.0%). The median OS was significantly shorter in patients with total OHAT scores ≥6 than in patients with scores < 6 (21 days vs. 43 days, p = .017). For individual OHAT items, the unhealthy status of the lips and tongue was associated with decreased OS (HR = 1.91; 95% confidence interval [CI], 1.19–3.05 and adjusted HR = 1.48; 95% CI, 1.00–2.20).ConclusionPredicting disease prognosis based on patient oral health can enable clinicians to provide timely treatment.
Young apheresis platelet donors show significant and sustained growth over the last decade in the US, 2010–2019: A favorable sign of the resiliency of the platelet supply
Authors: Lasky Baia , Singh Umesh , Young Pampee P. 
Published: May 2023

AbstractBackgroundPlatelet demand continues to rise and US hospitals frequently face shortages. The peak median age of apheresis platelet donors (APD) is believed to have increased over the last decade, raising concerns that the APD base is not being adequately replenished with young donors.Study Design/MethodsAmerican Red Cross (ARC) apheresis platelet collections were evaluated from calendar years 2010 through 2019. APD, products per procedure/split rate (PPP) and donation frequencies were stratified into age groups.Results/FindingsThe number of unique APD from calendar year 2010 through 2019 in the ARC donor pool increased from 87,573 to 115,372 donors, representing a 31.7% overall growth. Donors in the 16–40 year‐old (y) age group increased by 78.8% overall, with the largest absolute increases seen in the 26–30 y (4852 donors, 99.9% growth), followed by the 31–35 y (3991, 94.1%) group. Donors aged 56+ increased by 50.4% overall, with the largest increase seen in the 66–70 y (5988 donors, 108.1% growth) group. Middle‐aged donors, aged 41–55 y, demonstrated a decrease of 16.5%. Over the last decade, the youngest age groups (16–40 y) comprised 61.3% of first‐time donors (FTD). Annual donation frequency increased with increasing age and PPP. The highest donation frequencies were seen in the oldest age groups.ConclusionAlthough the peak median age of APD increased over the study period, relative contribution of the 16–40 y APD base also increased. Older donors exhibited the highest donation frequencies and thus contributed the largest volume of apheresis platelet units. Platelet donor activity declined in the middle age (41–55 y) group.
Sentinel lymph node mapping in canine mast cell tumours using a preoperative radiographic indirect lymphography: Technique description and results in 138 cases
Authors: Annoni Maurizio , Borgonovo Simone , Aralla Marina 
Published: May 2023

AbstractSeveral sentinel lymph node (SLN) mapping techniques, to detect nodal metastasis in canine tumours have been investigated in the last 10 years in veterinary oncology. The purpose of this prospective study was to describe a reliable, quick, and inexpensive technique for SLN mapping in canine patients affected by cutaneous and subcutaneous mast cell tumours (MCT). Eighty dogs were enrolled in this study for a total of 138 cytologically diagnosed MCTs. Sentinel lymph node mapping was performed by injecting iomeprole peritumorally followed by serial radiographs at 1, 3, 6 and 9‐min post injection. A total of 168 SLNs were detected, 90% at first radiograph, 1 min after the peritumoral iomeprole injection, while in the rest of the cases SLN was identified at 3 min. Sentinel lymph nodes detected by the preoperative radiographic indirect lymphography with iomeprole (PRILI) differed from regional lymph nodes in 57% of cases. The PRILI technique detected simultaneously multiple SLNs in the 26% of cases and multiple lymph centers in the 31% of MCTs. To allow the surgical identification of the SLNs, a peritumoral injection of methylene blue was performed at the time of surgery. This study reports a widely available technique for SLN mapping using digital radiographs in combination with a water‐soluble medium, representing a cost‐effective alternative to other SLN mapping procedures. Based on our results, this technique can be effective for SLNs mapping in dogs with MCTs but further comparative studies are needed to assess its reliability and efficacy in different tumours.
Evolving the gay, bisexual and other men who have sex with men time‐based deferral to sexual risk screening for all donors: The contribution of Canadian research programmes
Authors: Caffrey Niamh , O'Brien Sheila F. , Walsh Geraldine M. , Haw Jennie , Goldman Mindy 
Published: May 2023

AbstractBackground and ObjectivesIn Canada, the time deferral for gay, bisexual and other men who have sex with men (gbMSM) to donate blood has gradually decreased. In September 2022, this deferral was replaced with sexual behaviour‐based screening for all donors. We investigate how data from targeted research programmes addressed knowledge gaps to support this change.Materials and MethodsWe conducted a scoping review describing the Canadian literature available before the research programmes relating to (1) behavioural indicators of HIV risk and (2) attitudes to blood donation among gbMSM, current donors and the general population. We summarize the targeted research programmes, their outputs and impact to date.ResultsFor question 1, five projects met inclusion criteria. For question 2, three articles met inclusion criteria. Knowledge gaps identified were insufficient evidence of HIV incidence in gbMSM who met other donor eligibility criteria and scant data on opinions and views of blood donation and screening criteria for sexual risk behaviours. The research programmes funded 19 projects at 11 different research sites involving over 100 individual researchers/collaborators resulting in 19 peer‐reviewed publications to date. Leveraging existing gbMSM cohorts yielded relevant HIV incidence data to inform safety modelling studies. Findings indicated that sexual behaviour‐based screening was acceptable to gbMSM and donors, and donor discomfort around specific questions could be mitigated with clear explanations.ConclusionTargeted research programmes filled critical knowledge gaps and informed a change to gender‐neutral, sexual behaviour‐based screening for all donors. Findings supported successful implementation of these changes with research‐informed staff training.
Two Simple Numerical Implementation Methods for Damage-Coupled Viscoplastic Constitutive Model
Authors: Wang YuanLiang , Liao YanQing , Peng JiaHui , Ni YongZhong , Xu Hong 
Published: May 2023

Abstract
This paper is concerned with the two simple numerical implementation methods for a damage-coupled Chaboche-type viscoplastic constitutive model. By considering the damage variable as a constant in each incremental step, the return-mapping procedure is reduced to the solution of only one nonlinear scalar equation. Depending on the use of damage value in the current or prior incremental state, the two methods are named the backward difference implicit integration scheme and the two-step explicit integration scheme respectively. These two numerical algorithms are implemented into the ansys software by developing the usermat subroutine and verified by comparing them with available experimental data. Several numerical examples on the Gauss point level are studied in terms of stability, accuracy, computational efficiency, and applicability for further numerical observation. In addition to higher computational efficiency and lower memory requirements, the two methods can be easily extended to other damage models due to their simplicity.
Dislocation in a Strained Layer Embedded in a Semi-Infinite Matrix
Authors: Colin Jérôme 
Published: May 2023

Abstract
The misfit stress in a thin layer embedded in a semi-infinite matrix has been first determined near the free surface of the structure, using the virtual dislocation formalism. From a Peach–Koehler force analysis, the different equilibrium positions (unstable and stable) of an edge dislocation gliding in a plane of the layer inclined with respect to the upper interface and emerging at the point of intersection of the upper interface and this free surface have been then characterized with respect to the lattice mismatch and the inclination angle of the gliding plane. It has been found that the dislocation may exhibit stable equilibrium position near the interface and/or near the free surface. A diagram of the position stability has been then determined versus the misfit parameter and the inclination angle. The energy variation due to the introduction of an edge dislocation from the free surface until the matrix layer interface has been finally determined, when the dislocation is gliding in the plane inclined with respect to the interface horizontal axis. A critical thickness of the layer beyond which the formation of the dislocation in the interfaces is energetically favorable has been finally determined as well as its position with respect to the free surface in the lower interface.
Breaking plates: Creation of the East Anatolian fault, the Anatolian plate, and a tectonic escape system
Authors: Whitney Donna L. , Delph Jonathan R. , Thomson Stuart N. , Beck Susan L. , Brocard Gilles Y. , Cosca Michael A. , Darin Michael H. , Kaymakci Nuretdin , Meijers Maud J.M. , Okay Aral I. , Rojay Bora , Teyssier Christian , Umhoefer Paul J. 
Published: May 2023

Abstract
Lateral movement of lithospheric fragments along strike-slip faults in response to collision (escape tectonics) has characterized convergent settings since the onset of plate tectonics and is a mechanism for the formation of new plates. The Anatolian plate was created by the sequential connection of strike-slip faults following ≥10 m.y. of distributed deformation that ultimately localized into plate-bounding faults. Thermochronology data and seismic images of lithosphere structure near the East Anatolian fault zone (EAFZ) provide insights into the development of the new plate and escape system. Low-temperature thermochronology ages of rocks in and near the EAFZ are significantly younger than in other fault zones in the region, e.g., apatite (U-Th)/He: 11–1 Ma versus 27–13 Ma. Young apatite (U-Th)/He ages and thermal history modeling record thermal resetting along the EAFZ over the past ~5 m.y. and are interpreted to indicate thermal activity triggered by strike-slip faulting in the EAFZ as it formed as a through-going, lithosphere-scale structure. The mechanism for EAFZ formation may be discerned from S-wave velocity images from the Continental Dynamics–Central Anatolian Tectonics (CD-CAT) seismic experiment. These images indicate that thin but strong Arabian lithospheric mantle extends ~50–150 km north beneath Anatolian crust and would have been located near the present surficial location of the Bitlis-Zagros suture zone (co-located with the EAFZ in our study area) at ca. 5 Ma. Underthrusting of strong Arabian lithosphere facilitated localization of the EAFZ and thus was a fundamental control on the formation of the Anatolian plate and escape system.
Do microcontinents nucleate subduction initiation?
Authors: Zhu Mingshuai , Yan Zhiyong , Pastor-Galán Daniel , Chen Lin , Miao Laicheng , Zhang Fuqin , Li Shun , Yang Shunhu 
Published: May 2023

Abstract
Subduction initiation is a pivotal process in plate tectonics. Models of subduction initiation include the collapse of passive margins, oceanic transform faults, inversion of oceanic core complexes, and ridge failure but have ignored the potential effects of continental crust relicts within the oceanic crust. In this paper, we explore the role of microcontinents on subduction initiation through two-dimensional thermo-mechanical numerical modeling. We consider three scenarios with variable ages of oceanic crust surrounding the microcontinent and parametrically examine the microcontinent characteristics (size, crustal thickness, thermal gradient, and rheology), oceanic plate age, and convergence rates. Results suggest that moderate-size (≥300 km) microcontinents can nucleate subduction initiation at the junction between continental and oceanic plates. A large part of the microcontinent would be dragged into the subduction zone, and the subsequent asthenosphere upwellings would incorporate part of the microcontinent. Our numerical models add a new hypothetical scenario for subduction initiation, especially for those places where a young and buoyant plate subducts beneath an older and denser oceanic plate. Moreover, they can explain the origin of exotic crust materials and ultrahigh-pressure minerals in supra–subduction zone ophiolites.
Trends of healthy and unhealthy working life expectancy in Germany between 2001 and 2020 at ages 50 and 60: a question of educational level?
Authors: Sperlich Stefanie , Beller Johannes , Epping Jelena , Geyer Siegfried , Tetzlaff Juliane 
Published: May 2023

BackgroundExtending the number of active working years is an important goal both for maintaining individual quality of life and safeguarding social security systems. Against this background, we examined the development of healthy and unhealthy working life expectancy (HWLE/UHWLE) in the general population and for different educational groups.MethodsThe study is based on data from the German Socio-Economic Panel study, including 88 966 women and 85 585 men aged 50–64 years and covering four time periods (2001–05, 2006–2010, 2011–2015 and 2016–2020). Estimates of HWLE and UHWLE in terms of self-rated health (SRH) were calculated using the Sullivan’s method. We adjusted for hours worked and stratified by gender and educational level.ResultsWorking-hours adjusted HWLE at age 50 increased in women and men from 4.52 years (95% CI 4.42 to 4.62) in 2001–2005 to 6.88 years (95% CI 6.78 to 6.98) in 2016–2020 and from 7.54 years (95% CI 7.43 to 7.65) to 9.36 years (95% CI 9.25 to 9.46), respectively. Moreover, UHWLE also rose with the proportion of working life spent in good SRH (health ratio) remaining largely stable. At age 50, educational differences in HWLE between the lowest and highest educational groups increased over time in women and in men from 3.72 to 4.99 years and from 4.06 to 4.40 years, respectively.ConclusionsWe found evidence for an overall increase but also for substantial educational differences in working-hours adjusted HWLE, which widened between the lowest and highest educational group over time. Our findings suggest that policies and health prevention measures at workplace should be more focused on workers with low levels of education in order to extend their HWLE.
Macrophage-inherited exosome excise tumor immunosuppression to expedite immune-activated ferroptosis
Authors: Wang Duo , Qiu Guanhua , Zhu Xiaoqi , Wang Qin , Zhu Chunyan , Fang Chao , Liu Junjie , Zhang Kun , Liu Yan 
Published: May 2023

BackgroundImmunosuppressive tumor microenvironment (ITM) remains an obstacle that jeopardizes clinical immunotherapy.MethodsTo address this concern, we have engineered an exosome inherited from M1-pheototype macrophages, which thereby retain functions and ingredients of the parent M1-phenotype macrophages. The delivered RSL3 that serves as a common ferroptosis inducer can reduce the levels of ferroptosis hallmarkers (eg, glutathione and glutathione peroxidase 4), break the redox homeostasis to magnify oxidative stress accumulation, promote the expression of ferroptosis-related proteins, and induce robust ferroptosis of tumor cells, accompanied with which systematic immune response activation can bbe realized. M1 macrophage-derived exosomes can inherit more functions and genetic substances than nanovesicles since nanovesicles inevitably suffer from substance and function loss caused by extrusion-arised structural damage.ResultsInspired by it, spontaneous homing to tumor and M2-like macrophage polarization into M1-like ones are attained, which not only significantly magnify oxidative stress but also mitigate ITM including M2-like macrophage polarization and regulatory T cell decrease, and regulate death pathways.ConclusionsAll these actions accomplish a synergistic antitumor enhancement against tumor progression, thus paving a general route to mitigate ITM, activate immune responses, and magnify ferroptosis.
Nasal administration of recombinantNeospora caninumsecreting IL-15/IL-15Rα inhibits metastatic melanoma development in lung
Authors: Battistoni Arthur , Lantier Louis , di Tommaso Anne , Ducournau Céline , Lajoie Laurie , Samimi Mahtab , Coënon Loïs , Rivière Clément , Epardaud Mathieu , Hertereau Leslie , Poupée-Beaugé Agathe , Rieu Juliette , Mévélec Marie-Noëlle , Lee Gordon Scott , Moiré Nathalie , Germon Stephanie , Dimier-Poisson Isabelle 
Published: May 2023

BackgroundMetastases are the leading cause of mortality in many cancer types and lungs are one of the most common sites of metastasis alongside the liver, brain, and bones. In melanoma, 85% of late-stage patients harbor lung metastases. A local administration could enhance the targeting of metastases while limiting the systemic cytotoxicity. Therefore, intranasal administration of immunotherapeutic agents seems to be a promising approach to preferentially target lung metastases and decrease their burden on cancer mortality. From observations that certain microorganisms induce an acute infection of the tumor microenvironment leading to a local reactivating immune response, microbial-mediated immunotherapy is a next-generation field of investigation in which immunotherapies are engineered to overcome immune surveillance and escape from microenvironmental cancer defenses.MethodsThe goal of our study is to evaluate the potential of the intranasal administration ofNeospora caninumin a syngeneic C57BL6 mouse model of B16F10 melanoma lung metastases. It also compares the antitumoral properties of a wild-typeN. caninumversusN. caninumsecreting human interleukin (IL)-15 fused to the sushi domain of the IL-15 receptor α chain, a potent activator of cellular immune responses.ResultsThe treatment of murine lung metastases by intranasal administration of anN. caninumengineered to secrete human IL-15 impairs lung metastases from further progression with only 0,08% of lung surface harboring metastases versus 4,4% in wild-typeN. caninumtreated mice and 36% in untreated mice. The control of tumor development is associated with a strong increase in numbers, within the lung, of natural killer cells, CD8+T cells and macrophages, up to twofold, fivefold and sixfold, respectively. Analysis of expression levels of CD86 and CD206 on macrophages surface revealed a polarization of these macrophages towards an antitumoral M1 phenotype.ConclusionAdministration of IL-15/IL-15Rα-secretingN. caninumthrough intranasal administration, a non-invasive route, lend further support toN. caninum-demonstrated clear potential as an effective and safe immunotherapeutic approach for the treatment of metastatic solid cancers, whose existing therapeutic options are scarce. Combination of this armed protozoa with an intranasal route could reinforce the existing therapeutic arsenal against cancer and narrow the spectrum of incurable cancers.