bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neuronal selectivity for stimulus information determines prefrontal LFP gamma power regardless of task execution
Authors: Singh Balbir , Wang Zhengyang , Constantinidis Christos 
Published: January 2023

Abstract
Local field potential (LFP) power in gamma frequency has been thought to be modulated by cognitive variables during task execution. We sought to understand how the properties of neurons and LFPs from same sites representing information before and after training in cognitive tasks. We therefore trained monkeys to perform working memory tasks and analyzed the neurons and LFPs in different prefrontal subdivisions. In agreement with previous studies, we found that sites containing neurons selective for stimuli held in memory exhibit increased gamma power during and after the presentation of stimuli compared to the baseline period. Unexpectedly, we also found that the elevation of gamma power above the baseline was diminished after training, compared to power observed prior to training in the same monkeys; despite an overall in firing rate observed after training. Learning to perform the task did alter some properties of LFP gamma power, it decreased at the time that subjects needed to make a judgment about whether two stimuli were same or not, and differential gamma power was observed for matching and nonmatching stimuli. Our results indicate that gamma power elevation in the prefrontal cortex represents automatic stimulus processing, not necessarily tied to a cognitive task being executed.
Identification and phylogenetic analysis of R2R3-MYB subfamily in Brassica napus
Authors: luo Dingfan , Mei Desheng , Liu Jia , Wei Wenliang 
Published: January 2023

Abstract
Background: The majority of the MYB protein's members, plant-specific transcription factors (TFs) that are divided into four classes based on the number of MYB repeats, make up the R2R3-MYB subfamily of proteins. In particular, they play a role in the body's reactions to diverse biotic and abiotic stimuli. R2R3-MYB TFs are involved in physiological and biochemical processes. However, the functions of the rapeseed R2R3-MYBgenes are still mainly unknown (Brassica napus).
Results: In this study, a total of 35 BnaMYB genes were found in the rapeseed genome, and details about their physical and chemical characteristics, evolutionary relationships, chromosome locations, gene structures, three-dimensional protein structures, cis-acting promoter elements, and gene duplication were uncovered. The BnaMYB genes had undergone segmental duplications and positive selection pressure, according to the evolutionary study. The same subfamilies have similar intron-exon patterns and motifs, according to gene structure and conserved motif. Additionally, by cis-element analysis, many drought-response and other stress responsive cis-elements were found in the promoter regions of the BnaMYB genes. BnaMYB gene expression displayed a variety of tissue-specific patterns. Twenty of the BnaMYB genes, however, were primarily expressed in stems, therefore 10 lignin-related genes were chosen for drought treatment.
Conclusions: Our research screened four genes (BnaMYB7, BnaMYB11, BnaMYB26 and BnaMYB30)showed significant upregulation under drought stress, which may be important drought-response genes. The findings laid a new foundation for understanding the complex mechanisms of BnaMYB in multiple developmental stages and pathways related to drought stress in rapeseed.
Biomechanical outcomes of targeted endodontic microsurgery: 3D finite element analysis
Authors: Mon Aein , Kim Mi-El , Lim Young-Joon , Kim Myung-Joo , Kum Kee-Yeon , Kwon Hobeom 
Published: January 2023

AbstractThis study compared the biomechanical responses of resected teeth between endodontic microsurgery (horizontal resection) and targeted endodontic microsurgery (round resection). Five different models were developed. The basic model without resection (NR) was the control model, and the others involved: horizontal resection without bone grafting (HN), horizontal resection with bone grafting (HG), round resection without bone grafting (RN), and round resection with bone grafting (RG) models. The maximum von-Mises stress and tooth displacement values were analysed and compared. Both the HN and RN models exhibited lower stress distribution values on bone compared with the NR (control) model. Regarding maximum stress distribution at the root apex, the stress value of the RN model was slightly higher compared to the HN model, whereas the RG model displayed a slightly lower stress value in comparison with the HG model. For maximum tooth displacement value, there were no significant differences between the HN and RN models, as well as the HG and RG models. The round resection pattern had comparable stress distribution behaviours at the root apex and tooth displacement values with the horizontal resection pattern. Targeted endodontic microsurgery provides a favourable biomechanical response of the resected tooth after root-end resection.
Integrated Bioinformatic Analysis Reveals NOS2 as a Novel Ferroptosis-related Biomarker for Pre-eclampsia
Authors: Cai Shuangming , Huang Shan , Zhang Wenni , Xiao Huanshun , Yu Danfeng , Zhong Xuan , Tao Pei , Luo Yiping 
Published: January 2023

Abstract

Background Pre-eclampsia (PE) is a common condition in pregnancy; however, methods for early diagnosis and effective treatment options are lacking. Ferroptosis is a newly identified iron-dependent cell death pathway. The aim of this study was to investigate the role of ferroptosis-related genes in PE, the underlying mechanism, and their potential diagnostic value using a bioinformatics approach. Methods We downloaded the GSE48424 and GSE98224 datasets from the Gene Expression Omnibus database. Differentially expressed genes (DEGs) between PE and healthy pregnancy samples were identified in the GSE48424 dataset and subjected to weighted gene co-expression network analysis; the most relevant modules were intersected with known ferroptosis-related genes to distinctly identify the role of ferroptosis in PE. We further searched transcription factors and microRNAs that are predicted to regulate these ferroptosis-related genes, and patients in the GSE48424 dataset were divided into two groups according to high or low expression of the key ferroptosis-related genes associated with PE. To obtain robust key ferroptosis-related genes in PE, we validated their expression levels in the external dataset GSE98224. Finally, we performed a reverse transcription-quantitative polymerase chain reaction (RT-qPCR) assay of these genes to evaluate their expression in the placenta samples of patients with PE and normal pregnancy. Results The most relevant module of PE in the GSE48424 dataset comprising the 565 identified DEGs contained a total of 3661 genes. After overlapping, we obtained six ferroptosis-related genes involved in PE. Among these genes, patients with PE displaying lower expression levels ofNOS2and higher expression levels ofPTGS2had a higher ferroptosis potential index. The expression pattern ofNOS2was consistent in the GSE48424 and GSE98224 datasets. RT-qPCR data confirmed thatNOS2expression was more significantly elevated in patients with PE than in those with a normal pregnancy. Conclusions Our study explored the diagnostic value of ferroptosis-related genes in PE, and identifiedNOS2as the key gene linking ferroptosis and PE, suggesting a new candidate biomarker for early PE diagnosis.
Family-centered empowerment program on self-efficacy, quality of life and daily activity in patients with COVID-19
Authors: Heidari Mohammad , Ebrahimi Mohammad , Aliakbari Fatemeh , Raeisi Hadi 
Published: January 2023

Abstract
Background
Coronavirus disease 2019 (COVID-19) has become the most important challenge in the world healthcare system today. We investigated the effect of a family-centered empowerment program on the self-efficacy and quality of life daily activity level of patients with COVID-19.
Methods
A quasi-experimental study on 60 patients with COVID-19 discharged from Shahrekord hospitals was performed. For the intervention group, family-based empowerment training was performed, which included three training sessions for patient caregivers, and for the control group, only routine discharge training was performed. all patients fulfill questionaries’ include World Health Organization (WHO) quality of life, daily activities and Sherer self-efficacy before and three months after the study. data were analyzed by SPSS/21 with chi-square, ANOVA and Pearson tests.
Results
The results of a recent study showed that family-centered empowerment program in patients leads to improved quality of life (p = 0.001) and also a significant change in the level of daily activity in the intervention group compared to the control group (p = 0.001 but there was no significant difference between the two groups in terms of self-efficacy after three months.
Conclusion
In line with the results of a recent study, studies have shown that the empowerment program for patients' family caregivers can increase patient participation and daily activity level and overall quality of life by increasing their participation in patient care. It is recommended that this program be included in day-to-day care by nurses and patient caregivers in their training programs.
Contamination characteristics in runoff fractions from a nuclear facility in São Paulo/Brazil
Authors: Faustino Mainara Generoso , Monteiro Lucilena Rebelo , Lima Samia R. M. , Silva Tatiane B. S. C. da , Pirani Debora A. , Filho Walter dos Reis Pedreira , Gonzaga Roberta G. , Cotrim Marycel E. B. , Pires Maria Aparecida F. 
Published: January 2023

Abstract

The stormwater runoff may act as a nonpoint pollutant source and in urban environments contributes to aquatic ecosystem quality decay. Here, we examined the runoff characteristics on the export of total solids and total metals, as well as pH and conductivity responses during the rainfall evolution. In 2017 and 2018, 12 rain events in 4 sampling stations were monitored at a parking lot located at Nuclear and Energy Research Institute (IPEN/CNEN) in São Paulo/Brazil. A 4-chamber integrated collector allowed the sequential/temporal runoff evolution assessment. The runoff was composed of Ca > K > Mg > Si > Al > Fe > Na > Zn > Mn > Sr > Ti > Mo > V > Cu > B > Pb > Ni > Ce > Sb > Cr > La > U > Th > Cd. Total solids, Al and Fe exceed Brazilian water quality standards. Principal components analysis identified the elemental clusters linked to the facility activity, soil, traffic/atmospheric related deposition. Our results show that the runoff characteristics could be differentiated by pollutant source. Seasonal variation, rain event intensity, air mass from oceanic or continental origin, spatial distribution inside the monitoring area and the intensity of the first flush must be consider to disentangle the elemental clusters and pollution source contributions. In winter, continental air masses were associated with higher concentrations heavy metals in the surface runoff. Spatial changes with no seasonal variation were observed for U, Th, La and Ce.
The impact of geriatric characteristics and comorbidities on distant metastases and other cause mortality in older women with non-metastatic breast cancer treated with primary endocrine therapy
Authors: Waaijer M.E.C. , Lemij A.A. , de Boer A.Z. , Bastiaannet E. , Bos F. van den , Derks M.G.M. , Kroep J.R. , Liefers G.J. , Portielje J.E.A. , de Glas Nienke Aafke 
Published: January 2023

Abstract
Introduction In recent years, primary surgical treatment of older women with non-metastatic breast cancer has decreased in favor of primary endocrine therapy (PET). PET can be considered in women with a remaining life expectancy of less than five years. The aim of this study was to 1) assess the risk of distant metastases and other cause mortality over ten years in women aged 65 and older with stage I-III breast cancer treated with PET, 2) whether this was associated with geriatric characteristics and comorbidities and to 3) describe the reasons on which the choice for PET was made.
Methods Women were included from the retrospective FOCUS cohort, which comprises all incident women diagnosed with breast cancer aged 65 or older between January 1997 and December 2004 in the Comprehensive Cancer Center Region West in the Netherlands. We selected women (N=257) with stage I-III breast cancer and treated with PET from this cohort. Patient characteristics (including comorbidity, polypharmacy, walking, cognitive and sensory impairment), treatment and tumor characteristics were retrospectively extracted from charts. Outcomes were distant metastasis and other cause mortality. Cumulative incidences were calculated using the Cumulative Incidence for Competing Risks method (CICR); and subdistribution hazard ratios (SHR) were tested between groups based on age, geriatric characteristics and comorbidity with the Fine and Gray model.
Results Women treated with PET were on average 84 years old and 41% had one or more geriatric characteristics. Other cause mortality exceeded the cumulative incidence of distant metastasis over ten years (83 versus 5.6%). The risk of dying from another cause further increased in women with geriatric characteristics (SHR 2.06, p<0.001) or two or more comorbidities (SHR 1.72, p<0.001). Surgery was omitted mainly at the patient’s request (18.7%).
Discussion This study shows that the cumulative incidence of distant metastasis is much lower than other cause mortality in older women with breast cancer treated with PET, especially in the presence of geriatric characteristics or comorbidities. This confirms the importance of assessment of geriatric characteristics to aid counseling of older women.
A Unique Glycerophospholipid Metabolism Profile of Dilated Cardiomyopathy with Predictive value
Authors: Li Xiaolei , Adi Dilare , Aizezi Aibibanmu , Wang Yongtao , Liu Fen , Li Yanhong , Li Yanpeng , Wei Xian , Kerem Munawar , Ma Xiang , Ma Yi-Tong 
Published: January 2023

Abstract
(1) Objects: Our aim was to identify changes in the metabolome in dilated cardiomyopathy (DCM) as well as to construct a metabolic diagnostic model for DCM.
(2) Methods: We utilized non-targeted metabolomics with a cross-sectional cohort of age- and sex-matched DCM patients and controls. Metabolomics data were analyzed using orthogonal partial least squares-discriminant analysis (OPLS-DA) and pathway analysis. It was validated in combination with transcriptome sequencing data from public databases. Machine learning models were used for the diagnosis of DCM.
(3) Results: Using multiple analytical techniques, 130 metabolite alterations were identified in DCM compared to healthy controls. Perturbations in glycerophospholipid metabolism (GPL) were identified and validated as a characteristic metabolic pathway in DCM. Through the least absolute shrinkage and selection operator (LASSO), we identified the 7 most important GPL metabolites, including LysoPA (16:0/0:0), LysoPA (18:1(9Z)/0:0), PC (20:3(8Z,11Z,14Z)/20:1(11Z)), PC (20:0/14:0), LysoPC (16:0), PS(15:0/18:0), and PE(16:0/20:4 (5Z,8Z,11Z,14Z)). The machine learning models based on the seven metabolites all had good accuracy in distinguishing DCM [All area under the curve (AUC) >0.900], and the artificial neural network (ANN) model performed the most consistently (AUC: 0.919±0.075).
(4) Conclusions: This study demonstrates that GPL metabolism may play a contributing role in the pathophysiological mechanisms of DCM. The 7-GPL metabolite model may help for early diagnosis of DCM.
A Qualitative Exploration of Pharmacists' Perspectives and Attitudes Towards the 2021 Down-scheduling of Melatonin in Australia
Authors: Yeung Kingston , Lee Samantha K. M. , Bin Yu Sun , Cheung Janet M.Y. 
Published: January 2023

Abstract
Background
In Australia, prescription melatonin became ‘Pharmacist Only Medicine’ for people over 55 with insomnia from June 2021. However, little is known about pharmacists’ views on melatonin down-scheduling and their perceived impacts on practice.
Objectives
To explore the impact of melatonin down-scheduling on Australian community pharmacists’ practice.
Methods
A convenience sample of community pharmacists and pharmacy interns were recruited. Participants completed a pre-interview survey capturing demographic and professional practice details, followed by a semi-structured interview. Interviews were guided by a schedule of questions exploring the perceived role of melatonin, preparation/response to down-scheduling, practice changes and patient interactions. Interviews were digitally recorded, transcribed verbatim and analysed using the Framework Approach.
Results
Twenty-four interviews were conducted with Australian community pharmacists (n = 19) and intern pharmacists (n = 5). Pharmacists/intern pharmacists welcomed the increased accessibility of melatonin for patients. However, pharmacists perceived a disconnect between the guidelines, supply protocols and pack sizes with practice, making it difficult to monitor patient use of melatonin. The miscommunication of eligibility also contributed to patient-pharmacist tension when supply was denied. Importantly, 88% of participants indicated their interest in upskilling their knowledge in melatonin use in sleep, specifically formulation differences and dosage titration.
Conclusions
This study showed the need to refine and unify supply protocols and amend pack sizes in community pharmacy. With further support and training, pharmacists have the potential to extend their scope of practice in sleep health in tandem with the provision of over-the-counter sleep aids.
Mechanical stability, electronic and magnetic properties of XZrAs (X=Cr,Mn,V) half Heusler compounds
Authors: MOKHTARI H. , BOUMIA L. , MOKHTARI M. , DAHMANE F. , MANSOUR D. , KHENATA R. 
Published: January 2023

Abstract
The WIEN2k code was used to perform theoretical calculations on the structural, half-metallic, and elastic properties of XZrAs (X = Cr, Mn, and V) half-Heusler compounds. For the term of the potential exchange and correlation (XC), we calculated structural, electronic, and magnetic properties using the generalized gradient approximation. In all compounds, the type 1 in the ferromagnetic (FM) phases is more energetically stable than other type arrangement. The spin-up electrons of both XZrAs (X = Cr, Mn) half-Heusler compounds in the type III structure are semiconducting with energy gaps, whereas the spin-down electrons are metallic. VZrAs compounds have also been studied, but they have metallic properties in both type I and type III structures. XZrAs (X = Cr, Mn, and V) half-Heusler compounds are elastically stable and ductile, according to calculated Cij elastic constants. Finally, XZrAs (X = Cr, Mn) half-Heusler compounds were obtained true half-metal ferromagnetic materials (HMF) within 2.99 µB/f.u. and 1.99 µB/f.u. respectively at equilibrium lattice constant a = 6.142˚A, and 6.1196 for CrZrAs and MnZrAs respectively
Correlation between COVID-19 vaccination coverage and human development index
Authors: Rezaei Fatemeh , Vali Mohebat , Aune Dagfinn 
Published: January 2023

Abstract
Background
COVID − 19 vaccination is essential for controlling this pandemic. Many countries have begun COVID − 19 vaccination in December 2020. This study aimed to calculate the correlation between the Human Development Index (HDI) and COVID-19 vaccination coverage.
Methods
In this ecological study for data collection a data set was prepared, which included COVID-19 vaccination coverage, HDI, and its components (Life expectancy at birth, mean years of schooling, and Gross National Income per capita), and income for 130 countries. Association between COVID-19 vaccination coverage, HDI, and its components estimated using correlation coefficients. Also, the scatter plots of the HDI and vaccination coverage were drawn according to countries income.
Results
There was a very strong positive correlation between COVID-19 vaccination coverage with HDI (r = 0.86, p < 0.001) and life expectancy at birth (r = 0.84, p < 0.001), and there was also a strong correlation with mean years of schooling (r = 0.74, p < 0.001) and Gross National Income (r = 0.73, p < 0.001). When countries were stratified by income level, these correlations were stronger for the lower middle income and upper middle income countries, than for low income and high income countries.
Conclusion
The HDI and its components was positively correlated with COVID-19 vaccination coverage. Governments should facilitate COVID-19 vaccination strategies especially in low income countries.
Association between preoperative atrial fibrillation and postoperative delirium in patients with pulmonary hypertension: A secondary analysis of a retrospective cohort study
Authors: Zhang Hong , Zhang Lei , Gan Lu , Ning Haihui , Xing Bomin , Zhang Xiaoxiao , Liu Yatao 
Published: January 2023

AbstractBackground Postoperative delirium is the most common neuropsychiatric disorder in major surgery. Predisposing factors have been identified, but risk factors assessment useful for managing clinical intervention, has not received unanimous consent. This work aims to investigate the relationship between atrial fibrillation and postoperative delirium in patients with pulmonary hypertension in the United States. Methods This is a secondary analysis of a retrospective cohort study. Patients with pulmonary hypertension who underwent non-cardiac, non-obstetric surgery at the University of Washington Medical Center from April 2007 to September 2013 were enrolled in the original research. The incidences of postoperative delirium were compared between patients with and without atrial fibrillation. We used multivariable logistic regression, propensity score analysis, and an inverse probability-weighting model to ensure the robustness of our findings. Results 518 patients with pulmonary hypertension (151 and 367 patients were atrial fibrillation and non-atrial fibrillation, respectively) were included in this study. The overall incidence of postoperative delirium was 3%(16/518) ; it was 1.9% (9/367) and 5.8% (7/151) for non-atrial fibrillation and atrial fibrillation patients, respectively. In the inverse probability-weighting model, atrial fibrillation was associated with high postoperative delirium (OR = 3.02, 95% CI: 1.11–8.19,P = 0.030). Conclusions Atrial fibrillation may be associated with increased risk-adjusted postoperative delirium in patients with pulmonary hypertension. Thus, these patients should be adequately assessed, monitored and controlled in early stage.