bluuebunny/crossref_metadata_2025_split huggingface dataset:
Observation of SLAMS‐Like Structures Close to Martian Aphelion by MAVEN
Authors: Shuvalov S. D. , Grigorenko E. E. 
Published: May 2023

AbstractAccording to various orientation of the interplanetary magnetic field (IMF), the planetary shock can be either quasi‐parallel or quasi‐perpendicular. Under quasi‐parallel conditions a significant number of solar wind suprathermal particles are reflected from the shock and drift along IMF, forming an extended and highly turbulent region called the foreshock where various nonlinear plasma phenomena are observed. In this research, a case study of the structures in the foreshock region at Mars as observed by Mars Atmosphere and Volatile Evolution is performed close to Martian aphelion, when the foreshock wave activity is usually low. Data from plasma analyzer STATIC and magnetometer MAG is used to analyze ion beams angular spectrum and magnetic field dynamics. It is shown that the observed structures are consistent with Short Large‐Amplitude Magnetic Structures (SLAMS), commonly detected in foreshock regions of magnetized and unmagnetized bodies throughout the Solar system. Finally, the Alfven Mach number is calculated to analyze characteristics of the observed foreshock structures. The analysis shows that the observed SLAMS‐like structures at Mars are steepened waves formed by the ion cyclotron resonance between plasma waves propagating along the IMF and the back‐streaming scattered solar wind H+ and exospheric O+ and O2+ ions, with the dominant impact of O+ ions. The steepening process is accompanied with observation of gradients in the diffuse ion density near the bowshock, like it has been previously reported near the Earth (e.g., Scholer, 1993, https://doi.org/10.1029/92JA01875; Tsubouchi & Lembege, 2004, https://doi.org/10.1029/2003JA010014).
Influence of Shelf Break Processes on the Transport of Warm Waters Onto the Eastern Amundsen Sea Continental Shelf
Authors: Azaneu Marina , Webber Benjamin , Heywood Karen J. , Assmann Karen M. , Dotto Tiago S. , Abrahamsen E. Povl 
Published: May 2023

AbstractThe heat transported onto the continental shelf by Circumpolar Deep Water (CDW) is the main driver of ice shelf basal melting in the Amundsen Sea. Here, we investigate the slope current system and the variability of the heat transported through the Pine Island‐Thwaites central and eastern troughs using data from five moorings deployed in the region between 5 March 2012 and 7 February 2016. Substantial variability on intermonthly time scales (3–4 months) is observed in the onshore heat flux, driven primarily by zonal wind stress north of the shelf break. Heat content, onshore flow, and heat flux are highly correlated between central and eastern troughs, which are most likely dynamically linked by the zonal wind stress forcing. This is the first time this dynamic link between troughs is observed. In the eastern the Amundsen Sea, during the El Niño of 2015/2016, strong eastward winds led to lower temperatures over the continental shelf while the onshore heat flux is intensified. We hypothesize that this anti‐correlation between heat content and heat flux results from a strengthened eastward undercurrent leading to upwelling of a colder and deeper CDW variety. These results highlight the complex and heterogeneous response of this region to environmental and the importance of velocity data for understanding the dynamics in this region. It also suggests that the hypothesized link between large‐scale atmospheric forcing (e.g., El Niño‐Southern Oscillation) and ice‐shelf melt is not produced via changes in heat content, but instead via changes in onshore heat flux.
Grid Spacing Sensitivities of Simulated Mid‐Latitude and Tropical Mesoscale Convective Systems in the Convective Gray Zone
Authors: Ramos‐Valle A. N. , Prein A. F. , Ge M. , Wang D. , Giangrande S. E. 
Published: May 2023

AbstractThe main objective of this study is to observationally constrain processes in tropical and midlatitude mesoscale convective systems (MCSs), and to use these constraints for model evaluation. To accomplish this, we leverage MCS observations collected at the U.S. DOE Atmospheric Radiation Measurement (ARM) Southern Great Plains (SGP) site in Oklahoma and ARM's mobile GoAmazon2014/15 site in Manaus, Brazil (MAO). We simulate 13 and 11 of these observed MCSs at the SGP and MAO site, respectively, using the Weather Research and Forecasting model at 12‐, 4‐, 2‐, and 1‐km horizontal grid spacing. Observations from radiosondes, surface meteorology, and radar wind profilers are used to characterize MCS properties, such as MCS timing and location, cold pools, and convective drafts, and evaluate these simulations. SGP cases are found in better agreement with observations than MAO cases, and when simulated at 2 km, outperform simulations at 1 km regarding the timing of MCS overpass and the accuracy of surface variable trends. MAO simulations suggest a consistent improvement in model accuracy with increasing model resolution in depicting the downdraft structure, the timing of MCSs, and the surface variables changes, except for the latter two metrics at 2 km. Deficiencies are still evident at km‐scales, suggesting the need for higher resolution to simulate tropical MCSs. Overall, location‐dependent improvements in MCS representation are obtained with the increasing model resolution, prompting the evaluation of sub‐km scale simulations.
An Upscaled Model of Fill‐And‐Spill Hydrological Response
Authors: Taheri Mahkameh , Ranjram Mark , Craig James R. 
Published: May 2023

AbstractThe hydrology of wetland‐dominated landscapes is often controlled by a fill‐and‐spill mechanism, whereby surface depressions retain water and release it once a deficit is filled. The response of these systems to precipitation/snowmelt events is influenced by the local storage deficit and connectivity between storage features. To estimate runoff generated from a heterogeneous wetland complex, a closed‐form analytical upscaled probabilistic model is developed. The mathematical solution requires information on the distribution of initial deficits and wetland local contributing areas, which may be estimated via a combination of spatial analysis and field observation. The model is used to explore the influence of spatial heterogeneity of wetland properties including deficit depth, local contributing area, and cascade depth (the number of wetlands in‐series within a cascade) on runoff response. It is also used to clarify “gatekeeper” storage features role at large scales and for systems with shallow wetland cascade depths. The proposed solution is shown to be a generalization of the well‐known Probability Distributed Model and Xinanjiang runoff models, augmented to include information about local contributing areas and wetlands connectivity. The closed form probabilistic mathematical solution is verified by comparing results with Monte Carlo simulations. The proposed runoff model has been implemented in Raven, a hydrologic model, to test the method performance in lumped runoff simulation of wetland‐dominated basins influenced by fill‐and‐spill hydrology. This study can contribute to our understanding of wetland characteristics distribution on landscape hydrology, and compensate for insufficiently resolved elevation data in flat terrains where threshold criteria are hard to estimate.
Generalizing Scaling Laws for Mantle Convection With Mixed Heating
Authors: Ferrick Amy L. , Korenaga Jun 
Published: May 2023

AbstractConvection in planetary mantles is in the so‐called mixed heating mode; it is driven by heating from below, due to a hotter core, as well as heating from within, due to radiogenic heating and secular cooling. Thus, in order to model the thermal evolution of terrestrial planets, we require the parameterization of heat flux for mixed heated convection in particular. However, deriving such a parameterization from basic principles is an elusive task. While scaling laws for purely internal heating and purely basal heating have been successfully determined using the idea that thermal boundary layers are marginally stable, recent theoretical analyses have questioned the applicability of this idea to convection in the mixed heating mode. Here, we present a scaling approach that is rooted in the physics of convection, including the boundary layer stability criterion. We show that, as long as interactions between thermal boundary layers are properly accounted for, this criterion succeeds in describing relationships between thermal boundary layer (TBL) properties for mixed heated convection. The surface heat flux of a convecting fluid is locally determined by the properties of the upper TBL, as opposed to globally determined. Our foundational scaling approach can be readily extended to nearly any complexity of convection within planetary mantles.
Self-aligned single-electrode actuation of tangential and wineglass modes using PMN-PT
Authors: Erturk Ozan , Shambaugh Kilian , Park Ha-Seong , Lee Sang-Goo , Bhave Sunil A. 
Published: May 2023

AbstractConsidering the evolution of rotation sensing and timing applications realized in micro-electro-mechanical systems (MEMS), flexural mode resonant shapes are outperformed by bulk acoustic wave (BAW) counterparts by achieving higher frequencies with both electrostatic and piezoelectric transduction. Within the 1–30 MHz range, which hosts BAW gyroscopes and timing references, piezoelectric and electrostatic MEMS have similar transduction efficiency. Although, when designed intelligently, electrostatic transduction allows self-alignment between electrodes and the resonator for various BAW modes, misalignment is inevitable regarding piezoelectric transduction of BAW modes that require electrode patterning. In this paper transverse piezoelectric actuation of [011] oriented single crystal lead magnesium niobate–lead titanate (PMN–PT) thin film disks are shown to excite the tangential mode and family of elliptical compound resonant modes, utilizing a self-aligned and unpatterned electrode that spans the entire disk surface. The resonant mode coupling is achieved by employing a unique property of [011] PMN–PT, where the in-plane piezoelectric coefficients have opposite signs. Fabricating 1-port disk transducers, RF reflection measurements are performed that demonstrate the compound mode family shapes in the 1–30 MHz range. Independent verification of mode transduction is achieved using in-plane displacement measurements with Polytec’s laser Doppler vibrometer (LDV). While the tangential mode achieves a 40o/s dithering rate at 335 kHz resonant frequency, then = 2 wine-glass mode achieves 11.46 nm tip displacement at 8.42 MHz resonant frequency on a radius of 60 μm disk resonator in air. A single electrode resonator that can excite both tangential and wine-glass modes with such metrics lays the foundation for a BAW MEMS gyroscope with a built-in primary calibration stage.
Amygdala subdivisions exhibit aberrant whole-brain functional connectivity in relation to stress intolerance and psychotic symptoms in 22q11.2DS
Authors: Delavari Farnaz , Rafi Halima , Sandini Corrado , Murray Ryan J. , Latrèche Caren , Van De Ville Dimitri , Eliez Stephan 
Published: May 2023

AbstractThe amygdala is a key region in emotional regulation, which is often impaired in psychosis. However, it is unclear if amygdala dysfunction directly contributes to psychosis, or whether it contributes to psychosis through symptoms of emotional dysregulation. We studied the functional connectivity of amygdala subdivisions in patients with 22q11.2DS, a known genetic model for psychosis susceptibility. We investigated how dysmaturation of each subdivision’s connectivity contributes to positive psychotic symptoms and impaired tolerance to stress in deletion carriers. Longitudinally-repeated MRI scans from 105 patients with 22q11.2DS (64 at high-risk for psychosis and 37 with impaired tolerance to stress) and 120 healthy controls between the ages of 5 to 30 years were included. We calculated seed-based whole-brain functional connectivity for amygdalar subdivisions and employed a longitudinal multivariate approach to evaluate the developmental trajectory of functional connectivity across groups. Patients with 22q11.2DS presented a multivariate pattern of decreased basolateral amygdala (BLA)-frontal connectivity alongside increased BLA-hippocampal connectivity. Moreover, associations between developmental drops in centro-medial amygdala (CMA)-frontal connectivity to both impaired tolerance to stress and positive psychotic symptoms in deletion carriers were detected. Superficial amygdala hyperconnectivity to the striatum was revealed as a specific pattern arising in patients who develop mild to moderate positive psychotic symptoms. Overall, CMA-frontal dysconnectivity was found as a mutual neurobiological substrate in both impaired tolerance to stress and psychosis, suggesting a role in prodromal dysregulation of emotions in psychosis. While BLA dysconnectivity was found to be an early finding in patients with 22q11.2DS, which contributes to impaired tolerance to stress.
Call combinations and compositional processing in wild chimpanzees
Authors: Leroux Maël , Schel Anne M. , Wilke Claudia , Chandia Bosco , Zuberbühler Klaus , Slocombe Katie E. , Townsend Simon W. 
Published: May 2023

AbstractThrough syntax, i.e., the combination of words into larger phrases, language can express a limitless number of messages. Data in great apes, our closest-living relatives, are central to the reconstruction of syntax’s phylogenetic origins, yet are currently lacking. Here, we provide evidence for syntactic-like structuring in chimpanzee communication. Chimpanzees produce “alarm-huus” when surprised and “waa-barks” when potentially recruiting conspecifics during aggression or hunting. Anecdotal data suggested chimpanzees combine these calls specifically when encountering snakes. Using snake presentations, we confirm call combinations are produced when individuals encounter snakes and find that more individuals join the caller after hearing the combination. To test the meaning-bearing nature of the call combination, we use playbacks of artificially-constructed call combinations and both independent calls. Chimpanzees react most strongly to call combinations, showing longer looking responses, compared with both independent calls. We propose the “alarm-huu + waa-bark” represents a compositional syntactic-like structure, where the meaning of the call combination is derived from the meaning of its parts. Our work suggests that compositional structures may not have evolved de novo in the human lineage, but that the cognitive building-blocks facilitating syntax may have been present in our last common ancestor with chimpanzees.
The Fgf/Erf/NCoR1/2 repressive axis controls trophoblast cell fate
Authors: Lackner Andreas , Müller Michael , Gamperl Magdalena , Stoeva Delyana , Langmann Olivia , Papuchova Henrieta , Roitinger Elisabeth , Dürnberger Gerhard , Imre Richard , Mechtler Karl , Latos Paulina A. 
Published: May 2023

AbstractPlacental development relies on coordinated cell fate decisions governed by signalling inputs. However, little is known about how signalling cues are transformed into repressive mechanisms triggering lineage-specific transcriptional signatures. Here, we demonstrate that upon inhibition of the Fgf/Erk pathway in mouse trophoblast stem cells (TSCs), the Ets2 repressor factor (Erf) interacts with the Nuclear Receptor Co-Repressor Complex 1 and 2 (NCoR1/2) and recruits it to key trophoblast genes. Genetic ablation of Erf or Tbl1x (a component of the NCoR1/2 complex) abrogates the Erf/NCoR1/2 interaction. This leads to mis-expression of Erf/NCoR1/2 target genes, resulting in a TSC differentiation defect. Mechanistically, Erf regulates expression of these genes by recruiting the NCoR1/2 complex and decommissioning their H3K27ac-dependent enhancers. Our findings uncover how the Fgf/Erf/NCoR1/2 repressive axis governs cell fate and placental development, providing a paradigm for Fgf-mediated transcriptional control.
Reversible transitions between noradrenergic and mesenchymal tumor identities define cell plasticity in neuroblastoma
Authors: Thirant Cécile , Peltier Agathe , Durand Simon , Kramdi Amira , Louis-Brennetot Caroline , Pierre-Eugène Cécile , Gautier Margot , Costa Ana , Grelier Amandine , Zaïdi Sakina , Gruel Nadège , Jimenez Irène , Lapouble Eve , Pierron Gaëlle , Sitbon Déborah , Brisse Hervé J. , Gauthier Arnaud , Fréneaux Paul , Grossetête Sandrine , Baudrin Laura G. , Raynal Virginie , Baulande Sylvain , Bellini Angela , Bhalshankar Jaydutt , Carcaboso Angel M. , Geoerger Birgit , Rohrer Hermann , Surdez Didier , Boeva Valentina , Schleiermacher Gudrun , Delattre Olivier , Janoueix-Lerosey Isabelle 
Published: May 2023

AbstractNoradrenergic and mesenchymal identities have been characterized in neuroblastoma cell lines according to their epigenetic landscapes and core regulatory circuitries. However, their relationship and relative contribution in patient tumors remain poorly defined. We now document spontaneous and reversible plasticity between the two identities, associated with epigenetic reprogramming, in several neuroblastoma models. Interestingly, xenografts with cells from each identity eventually harbor a noradrenergic phenotype suggesting that the microenvironment provides a powerful pressure towards this phenotype. Accordingly, such a noradrenergic cell identity is systematically observed in single-cell RNA-seq of 18 tumor biopsies and 15 PDX models. Yet, a subpopulation of these noradrenergic tumor cells presents with mesenchymal features that are shared with plasticity models, indicating that the plasticity described in these models has relevance in neuroblastoma patients. This work therefore emphasizes that intrinsic plasticity properties of neuroblastoma cells are dependent upon external cues of the environment to drive cell identity.
Genomic mutation landscape of skin cancers from DNA repair-deficient xeroderma pigmentosum patients
Authors: Yurchenko Andrey A. , Rajabi Fatemeh , Braz-Petta Tirzah , Fassihi Hiva , Lehmann Alan , Nishigori Chikako , Wang Jinxin , Padioleau Ismael , Gunbin Konstantin , Panunzi Leonardo , Morice-Picard Fanny , Laplante Pierre , Robert Caroline , Kannouche Patricia L. , Menck Carlos F. M. , Sarasin Alain , Nikolaev Sergey I. 
Published: May 2023

AbstractXeroderma pigmentosum (XP) is a genetic disorder caused by mutations in genes of the Nucleotide Excision Repair (NER) pathway (groups A-G) or in Translesion Synthesis DNA polymerase η (V). XP is associated with an increased skin cancer risk, reaching, for some groups, several thousand-fold compared to the general population. Here, we analyze 38 skin cancer genomes from five XP groups. We find that the activity of NER determines heterogeneity of the mutation rates across skin cancer genomes and that transcription-coupled NER extends beyond the gene boundaries reducing the intergenic mutation rate. Mutational profile in XP-V tumors and experiments with POLH knockout cell line reveal the role of polymerase η in the error-free bypass of (i) rare TpG and TpA DNA lesions, (ii) 3’ nucleotides in pyrimidine dimers, and (iii) TpT photodimers. Our study unravels the genetic basis of skin cancer risk in XP and provides insights into the mechanisms reducing UV-induced mutagenesis in the general population.
Conceptual and quantitative categorization of wave-induced flooding impacts for pedestrians and assets in urban beaches
Authors: Garzon J. L. , Ferreira Ó. , Reis M. T. , Ferreira A. , Fortes C. J. E. M. , Zózimo A. C. 
Published: May 2023

AbstractBeaches combined with sloping structures are frequently the first element of defense to protect urban areas from the impact of extreme coastal flooding events. However, these structures are rarely designed for null wave overtopping discharges, accepting that waves can pass above the crest and threat exposed elements in hinterland areas, such as pedestrians, urban elements and buildings, and vehicles. To reduce risks, Early Warning Systems (EWSs) can be used to anticipate and minimize the impacts of flooding episodes on those elements. A key aspect of these systems is the definition of non-admissible discharge levels that trigger significant impacts. However, large discrepancies in defining these discharge levels and the associated impacts are found among the existing methods to assess floodings. Due to the lack of standardization, a new conceptual and quantitative four-level (from no-impact to high-impact) categorization of flood warnings (EW-Coast) is proposed. EW-Coast integrates and unifies previous methods and builds on them by incorporating field-based information. Thus, the new categorization successfully predicted the impact level on 70%, 82%, and 85% of the overtopping episodes affecting pedestrians, urban elements and buildings, and vehicles, respectively. This demonstrates its suitability to support EWSs in areas vulnerable to wave-induced flooding.
Giraffes make decisions based on statistical information
Authors: Caicoya Alvaro L. , Colell Montserrat , Amici Federica 
Published: May 2023

AbstractThe ability to make inferences based on statistical information has so far been tested only in animals having large brains in relation to their body size, like primates and parrots. Here we tested if giraffes (Giraffa camelopardalis), despite having a smaller relative brain size, can rely on relative frequencies to predict sampling outcomes. We presented them with two transparent containers filled with different quantities of highly-liked food and less-preferred food. The experimenter covertly drew one piece of food from each container, and let the giraffe choose between the two options. In the first task, we varied the quantity and relative frequency of highly-liked and less-preferred food pieces. In the second task, we inserted a physical barrier in both containers, so giraffes only had to take into account the upper part of the container when predicting the outcome. In both tasks giraffes successfully selected the container more likely to provide the highly-liked food, integrating physical information to correctly predict sampling information. By ruling out alternative explanations based on simpler quantity heuristics and learning processes, we showed that giraffes can make decisions based on statistical inferences.
Watercraft decontamination practices to reduce the viability of aquatic invasive species implicated in overland transport
Authors: Mohit Shrisha , Johnson Timothy B. , Arnott Shelley E. 
Published: May 2023

AbstractRecreational boating activities enable aquatic invasive species (AIS) dispersal among disconnected lakes, as invertebrates and plants caught on or contained within watercraft and equipment used in invaded waterbodies can survive overland transport. Besides simple preventive measures such as "clean, drain, dry", resource management agencies recommend decontaminating watercraft and equipment using high water pressure, rinsing with hot water, or air-drying to inhibit this mode of secondary spread. There is a lack of studies assessing the efficacy of these methods under realistic conditions and their feasibility for recreational boaters. Hence, we addressed this knowledge gap via experiments on six invertebrate and plant AIS present in Ontario. Washing at high pressures of 900–1200 psi removed the most biological material (90%) from surfaces. Brief (< 10 s) exposure to water at ≥ 60 °C caused nearly 100% mortality among all species tested, except banded mystery snails. Acclimation to temperatures from 15 to 30 °C before hot water exposure had little effect on the minimum temperature required for no survival. Air-drying durations producing complete mortality were ≥ 60 h for zebra mussels and spiny waterfleas, and ≥ 6 days among plants, whereas survival remained high among snails after a week of air-drying. Hot water exposure followed by air-drying was more effective than either method separately against all species tested.