bluuebunny/crossref_metadata_2025_split huggingface dataset:
A new control parameter to predict micro-warping-induced job failure in LPBF of TI6AL4V titanium alloy
Authors: Buffa Gianluca , Costa Antonio , Palmeri Dina , Pollara Gaetano , Barcellona Antonio , Fratini Livan 
Published: March 2023

Abstract
Laser powder bed fusion (LPBF) includes a few printing techniques widely used, in recent years, concerning the additive manufacturing of Ti6Al4V alloys. These produced parts, typically utilized in sectors such as aerospace and biomedical, are characterized by very high added value. It is therefore fundamental to identify the influence of process parameters typical of LPBF technology on the occurrence of warping leading to process failure. This study deals with the characterization of single-track and “micro-scale” level warping phenomena which may lead to protrusion of material over the powder bed and process failure before normal termination. This phenomenon was investigated as a function of process parameters, referring also to the strength and ductility characteristics of the manufactured samples. With this purpose, several samples were printed using variable process parameters both in terms of line energy density (LED) values and in terms of laser power and speed combinations such as to guarantee constant LED values. For the samples that did not show significant micro-warping phenomena, in addition to the transversal and longitudinal geometric characterization of the single track, tensile tests were performed to determine both the resistance of the material and the ductility characteristics. The single tracks, for given process parameters, were printed on a homogeneous material substrate. For every single track, a microstructural and morphological transverse and longitudinal characterization has been carried out and the measured geometrical features were correlated to the process parameters. The obtained results allowed the identification of a new threshold parameter, indicating the limit operating conditions beyond which significant warping phenomena and process failure occur.
Modified Intestinal Derotation Procedure with Reversed Kocherization to Facilitate Mesopancreas Excision During Pancreaticoduodenectomy
Authors: Watanabe Genki , Satou Shouichi , Tanaka Motomu , Momiyama Masashi , Nakajima Kentaro , Nagao Atsuki , Satodate Hitoshi , Noie Tamaki 
Published: March 2023

AbstractBackgroundAlthough intestinal derotation procedure has advantages of facilitating mesopancreas excision during pancreaticoduodenectomy, the wide mobilization takes time and risks injuring other organs. This article describes a modified intestinal derotation procedure in pancreaticoduodenectomy and its clinical impact on short‐term outcomes.MethodsThe modified procedure comprised the pinpoint mobilization of the proximal jejunum following reversed Kocherization. Among 99 consecutive patients who underwent pancreaticoduodenectomy between 2016 and 2022, the short‐term outcomes of pancreaticoduodenectomy with the modified procedure were compared with those of conventional pancreaticoduodenectomy. The feasibility of the modified procedure was investigated based on the vascular anatomy of the mesopancreas.ResultsCompared with conventional pancreaticoduodenectomy (n = 55), the modified procedure (n = 44) involved less blood loss and shorter operation time (p < 0.001 and 0.017, respectively). Severe morbidity, clinically relevant postoperative pancreatic fistula, and prolonged hospitalization occurred less often with the modified procedure compared with conventional pancreaticoduodenectomy (p = 0.003, 0.008, and < 0.001, respectively). According to preoperative image findings, most (72%) patients had a single inferior pancreaticoduodenal artery sharing a common trunk with the first jejunal artery. The inferior pancreaticoduodenal vein drained into the jejunal vein in 71% of the patients. The first jejunal vein ran behind the superior mesenteric artery in 77% of the patients.ConclusionsBy combining our modified intestinal derotation procedure with preoperative recognition of the vascular anatomy of mesopancreas, mesopancreas excision during pancreaticoduodenectomy can be performed safely and accurately.
Effect of 3D-bioprinted droplet impact dynamics on a pre-printed soft hydrogel matrix
Authors: Chen Xinxing , O’Mahony Aidan P. , Barber Tracie J. 
Published: March 2023

Abstract3D droplet-based bioprinting technology is an innovative and time-saving method to precisely generate cell laden 3D structures for multiple clinical and research applications. It is important that the printed droplet must impact so as to leave a single isolated drop, for high printing resolution and accuracy. Therefore, understanding the criteria that control spreading behaviour and prevent droplet splashing is of great importance in optimizing the printing performance. In this experimental work, the physics of the impact of bioink droplets on a pre-printed soft hydrogel matrix was investigated. The droplet size, velocity, and input cell density were varied to generate a range of droplet impact behaviours. It has been shown that the soft substrate inhibited the droplet spreading after impact. The deposition/splashing boundary on the dry/wet flat surface (Nunclon $$^{\text{TM}}$$

TM

Delta surface-treated plastic) was defined by $$K = {\text{We}}^{0.5} {\text{Re}} ^{0.25} = 86.19$$

K
=

We

0.5

Re

0.25

=
86.19

. The splashing threshold on the soft hydrogel matrix was defined by $$K = 44.78$$

K
=
44.78

and $$L = {\text{We}} {\text{Re}}^{-0.4} = 13.85$$

L
=

WeRe

-
0.4

=
13.85

for both blank and cell-laden inks on dry/wet soft substrates. Beyond this threshold, the printed droplet volume will be much lower than the expected volume due to splashing, leading to poor printing performance. The absolute splashing threshold on the dry/wet soft hydrogel matrix was defined by $$K = 73.41$$

K
=
73.41

and $$L = 27.36$$

L
=
27.36

. The printed 3D cell-laden structures were also presented to illustrate how the impact behaviours influence the possible printing fidelity and structure integrity.
Contemporary oceanic radiocarbon response to ocean circulation changes
Authors: Pookkandy Byju , Graven Heather , Martin Adrian 
Published: March 2023

AbstractRadiocarbon (14C) is a valuable tracer of ocean circulation, owing to its natural decay over thousands of years and to its perturbation by nuclear weapons testing in the 1950s and 1960s. Previous studies have used 14C to evaluate models or to investigate past climate change. However, the relationship between ocean 14C and ocean circulation changes over the past few decades has not been explored. Here we use an Ocean-Sea-ice model (NEMO) forced with transient or fixed atmospheric reanalysis (JRA-55-do) and atmospheric 14C and CO2 boundary conditions to investigate the effect of ocean circulation trends and variability on 14C. We find that 14C/C (∆14C) variability is generally anti-correlated with potential density variability. The areas where the largest variability occurs varies by depth: in upwelling regions at the surface, at the edges of the subtropical gyres at 300 m depth, and in Antarctic Intermediate Water and North Atlantic Deep Water at 1000 m depth. We find that trends in the Atlantic Meridional Overturning Circulation may influence trends in ∆14C in the North Atlantic. In the high-variability regions the simulated variations are larger than typical ocean ∆14C measurement uncertainty of 2–5‰ suggesting that ∆14C data could provide a useful tracer of circulation changes.
Unusually high SO2 emissions and plume height from Piton de la Fournaise volcano during the April 2020 eruption
Authors: Hayer C. , Burton M. , Ferrazzini V. , Esse B. , Di Muro A. 
Published: March 2023

AbstractPiton de la Fournaise volcano, La Réunion, France, erupted between the 2 and 6 April 2020, one of a series of eruptive phases which occur typically two or three times per year. Here, we use back trajectory analysis of satellite data from the TROPOMI instrument to determine that gas emissions during the June 2020 eruption were of unusually high intensity and altitude, producing 34.9 ± 17.4 kt of SO2 and plume heights up to 5 km a.s.l. The early stages of the eruption (2–4 April 2020) were characterised by relatively low SO2 emission rates despite strong low frequency tremor (LFT); the latter phase followed an increase in intensity and explosivity in the early hours of 5 April 2020. This period included lava fountaining, significantly increased SO2 emission rates, increased high frequency tremor (HFT) and decreased LFT. Using the PlumeTraj back trajectory analysis toolkit, we found the peak SO2 emission rate was 284 ± 130 kg/s on the 6 April. The plume altitude peaked at ~ 5 km a.s.l. on 5 April, in the hours following a sudden increase in explosivity, producing one of the tallest eruption columns recorded at Piton de la Fournaise. PlumeTraj allowed us to discriminate each day’s SO2, which otherwise would have led to a mass overestimate due to the plumes remaining visible for more than 24 h. The eruption exhibited a remarkable decoupling and anti-correlation between the intensity of the LFT signal and that of the magma and gas emission rates. LFT intensity peaked during the first phase with low magma and SO2 emissions, but quickly decreased during the second phase, replaced by unusually strong HFT. We conclude that the observation of strong HFT is associated with higher intensity of eruption, degassing, and greater height of neutral buoyancy of the plume, which may provide an alert to the presence of greater hazards produced by higher intensity eruptive activity. This might be particularly useful when direct visual observation is prevented by meteorological conditions. This eruption shows the importance of combining multiple data sets when monitoring volcanoes. Combining gas and seismic data sets allowed for a much more accurate assessment of the eruption than either could have done alone.
Linear Orthosets and Orthogeometries
Authors: Paseka Jan , Vetterlein Thomas 
Published: March 2023

AbstractAnisotropic Hermitian spaces can be characterised as anisotropic orthogeometries, that is, as projective spaces that are additionally endowed with a suitable orthogonality relation. But linear dependence is uniquely determined by the orthogonality relation and hence it makes sense to investigate solely the latter. It turns out that by means of orthosets, which are structures based on a symmetric, irreflexive binary relation, we can achieve a quite compact description of the inner-product spaces under consideration. In particular, Pasch’s axiom, or any of its variants, is no longer needed. Having established the correspondence between anisotropic Hermitian spaces on the one hand and so-called linear orthosets on the other hand, we moreover consider the respective symmetries. We present a version of Wigner’s Theorem adapted to the present context.
Feasibility of a virtual reality intervention targeting distress and anxiety symptoms in patients with primary brain tumors: Interim analysis of a phase 2 clinical trial
Authors: King Amanda L. , Roche Kayla N. , Leeper Heather E. , Vera Elizabeth , Mendoza Tito , Mentges Kelly , Acquaye-Mallory Alvina A. , Adegbesan Kendra A. , Boris Lisa , Burton Eric , Choi Anna , Grajkowska Ewa , Kunst Tricia , Levine Jason , Lollo Nicole , Miller Hope , Panzer Marissa , Penas-Prado Marta , Pillai Valentina , Polskin Lily , Reyes Jennifer , Sahebjam Solmaz , Stockdill Macy L. , Theeler Brett J. , Wu Jing , Gilbert Mark R. , Armstrong Terri S. 
Published: March 2023

Abstract
Purpose
Cancer patients experience distress and anxiety when undergoing imaging studies to monitor disease status, yet these symptoms are not always appropriately identified or well-managed. This interim analysis of a phase 2 clinical trial explored feasibility and acceptability of a virtual reality relaxation (VR) intervention for primary brain tumor (PBT) patients at the time of clinical evaluation.

Methods
English speaking, adult PBT patients with previous reports of distress and upcoming neuroimaging were recruited between March of 2021 and March 2022. A brief VR session was done within 2 weeks prior to neuroimaging with patient-reported outcomes (PROs) collected before and immediately post-intervention. Self-directed VR use over the next 1 month was encouraged with additional PROs assessments at 1 and 4 weeks. Feasibility metrics included enrollment, eligibility, attrition, and device-related adverse effects with satisfaction measured with qualitative phone interviews.

Results
Fifty-five patients were approached via email, 40 (73%) responded and 20 (50%) enrolled (9 declines, 11 screen fails). 65% of participants were ≤ 50 years, 50% were male, 90% were White/non-Hispanic, 85% had good KPS (≥ 90), and most were on active treatment. All patients completed the VR intervention, PROs questionnaires, weekly check-ins, and qualitative interview. Most (90%) reported frequent VR use and high satisfaction and only 7 mild AEs were recorded (headache, dizziness, nausea, neck pain).

Conclusion
This interim analysis supports feasibility and acceptability of a novel VR intervention to target psychological symptoms for PBT patients. Trial enrollment will continue to assess for intervention efficacy.

Trial Registration
NCT04301089 registered on 3/9/2020.
Speciated and Total Urinary Arsenic Levels in Belo Horizonte, the Largest Brazilian City within the Mineral-Rich Region “Iron Quadrangle”
Authors: Campolina Délio , Ciminelli Virginia S. T. , Ng Jack C. , Campolina Thiago A. M. , Caldeira Cláudia L. , Gutiérrez-Aviña Ximena , Islam Md N. 
Published: March 2023

AbstractThe “Quadrilátero Ferrífero” (Iron Quadrangle) is a mineral-rich province in Brazil, where arsenic anomalies are associated with gold mining and tailings dam failures. Urine samples were randomly collected from residents of Belo Horizonte (BH) city (N = 506 total/138 speciation) and the metropolitan area (N = 35 total/10 speciation), with stratifications in age, female-male and geopolitical regions. Creatinine, acid-digested total arsenic (TAs), and five inorganic and organic arsenic species were measured: arsenobetaine (AsB); arsenous (AsIII) and arsenic (AsV) acids and their dissociation products; monomethylarsonic acid (MMA); and dimethylarsinic acid DMA). Overall, the TAs GM (μg/g creat) of all stratification groups indicated no statistical difference. The TAs geometric mean (GM) of BH was 9.68 [9.17–10.2] μg/g creat, being AsB (43.8%) and DMA (20.7%) the major components. The toxic arsenic (ToxAs) fraction (i.e., AsIII + AsV + MMA + DMA) was 5.23 [4.45–6.15] μg/L. These TAs and ToxAs values are lower than international benchmarks and the Brazilian legislated standard of 35 μg/L for ToxAs. The TAs GM (μg/L) and creatinine were 36% higher for males than for females (p < 0.0001), making TAs GMs comparable, after creatinine correction. Similarly, though the 10–19 age group showed significantly higher ToxAs GM (12.7 [6.49–24.8] μg/L) (p = 0.048) and creatinine (p < 0.001), the ToxAs GM (7.22 [2.92–17.9] μg/g creat), was not statistically different than those from the other age groups. The study, the first one in Brazil, identifies the relative contribution of inorganic and organic arsenic and provides a baseline level for clinical reference and bio-monitoring studies, particularly applicable to both occupational and non-occupational populations in a mineral-rich region.
Graphical abstract
1,25-Dihydroxyvitamin D3 alleviates hyperandrogen-induced ferroptosis in KGN cells
Authors: Jiang Yijie , Yang Jianshu , Du Ke , Luo Kaiming , Yuan Xin , Hua Fei 
Published: March 2023

Abstract
Purpose
Hyperandrogenism, one of the most frequent causes of anovulation in women, increases the risk of metabolic disorders in patients with polycystic ovary syndrome (PCOS). Ferroptosis, characterized by iron-dependent lipid peroxidation, has provided new insight into the progression of PCOS. 1,25-dihydroxyvitamin D3 (1,25D3) may play a role in reproduction because its receptor, VDR, which contributes to the inhibition of oxidative stress, is primarily located in the nuclei of granulosa cells. This study has therefore investigated whether 1,25D3 and hyperandrogenism affect granulosa-like tumor cells (KGN cells) through ferroptosis.

Methods
KGN cells were treated with dehydroepiandrosterone (DHEA) or pretreated with 1,25D3. Cell viability was evaluated with the cell counting kit-8 (CCK-8) assay. The mRNA and protein expression levels of ferroptosis-related molecules, including glutathione peroxidase 4 (GPX4), solute carrier family 7 member (SLC7A11), and long-chain acyl-CoA synthetase 4 (ACSL4), were assessed via qRT–PCR and western blot. The concentration of malondialdehyde (MDA) was measured by ELISA. The rates of reactive oxygen species (ROS) production and lipid peroxidation were assessed via photometric methods.

Results
Decreased cell viability, suppression of GPX4 and SLC7A11 expression, increased expression of ACSL4, elevated levels of MDA, accumulation of ROS, and increased lipid peroxidation, which are changes representative of ferroptosis, were observed in KGN cells after treatment with DHEA. Pretreatment with 1,25D3 in KGN cells significantly prevented these changes.

Conclusions
Our findings demonstrate that 1,25D3 attenuates hyperandrogen-induced ferroptosis of KGN cells. This finding might lead to new insights into the pathophysiology and therapy of PCOS and provides new evidence for the treatment of PCOS with 1,25D3.
Observability for Schrödinger equations with quadratic Hamiltonians
Authors: Waters Alden 
Published: March 2023

AbstractWe consider time dependent harmonic oscillators and construct a parametrix to the corresponding Schrödinger equation using Gaussian wavepackets. This parametrix of Gaussian wavepackets is precise and tractable. Using this parametrix we prove $$L^2$$

L
2

and $$L^2-L^{\infty }$$

L
2

-

L
∞

observability estimates on unbounded domains $$\omega $$
ω
for a restricted class of initial data. This data includes a class of compactly supported piecewise $$C^1$$

C
1

functions which have been extended from characteristic functions. Initial data of this form which has the bulk of its mass away from $$\omega ^c=\Omega $$

ω
c

=
Ω

, a connected bounded domain, is observable, but data centered over $$\Omega $$
Ω
must be very nearly a single Gaussian to be observable. We also give counterexamples to established principles for the simple harmonic oscillator in the case of certain time dependent harmonic oscillators.
An ergodic theorem for asymptotically periodic time-inhomogeneous Markov processes, with application to quasi-stationarity with moving boundaries
Authors: Oçafrain William 
Published: March 2023

AbstractThis paper deals with ergodic theorems for particular time-inhomogeneous Markov processes, whose time-inhomogeneity is asymptotically periodic. Under a Lyapunov/minorization condition, it is shown that, for any measurable bounded function f, the time average
$\frac{1}{t} \int_0^t f(X_s)ds$
converges in
$\mathbb{L}^2$
towards a limiting distribution, starting from any initial distribution for the process
$(X_t)_{t \geq 0}$
. This convergence can be improved to an almost sure convergence under an additional assumption on the initial measure. This result is then applied to show the existence of a quasi-ergodic distribution for processes absorbed by an asymptotically periodic moving boundary, satisfying a conditional Doeblin condition.
Sandwiched SDEs with unbounded drift driven by Hölder noises
Authors: Di Nunno Giulia , Mishura Yuliya , Yurchenko-Tytarenko Anton 
Published: March 2023

AbstractWe study a stochastic differential equation with an unbounded drift and general Hölder continuous noise of order
$\lambda \in (0,1)$
. The corresponding equation turns out to have a unique solution that, depending on a particular shape of the drift, either stays above some continuous function or has continuous upper and lower bounds. Under some mild assumptions on the noise, we prove that the solution has moments of all orders. In addition, we provide its connection to the solution of some Skorokhod reflection problem. As an illustration of our results and motivation for applications, we also suggest two stochastic volatility models which we regard as generalizations of the CIR and CEV processes. We complete the study by providing a numerical scheme for the solution.
Analysis of infections among patients with historical culture positive for extended-spectrum beta-lactamase (ESBL)–producing Escherichia coli or Klebsiella pneumoniae: Is ESBL-targeted therapy always needed?
Authors: Stone Tyler J. , DeWitt Michael , Johnson James W. , Beardsley James R. , Munawar Iqra , Palavecino Elizabeth , Luther Vera P. , Ohl Christopher A. , Williamson John C. 
Published: March 2023

Abstract

Objective:
Among patients with a history of ESBL infection, uncertainty remains regarding whether all of these patients require ESBL-targeted therapy when presenting with a subsequent infection. We sought to determine the risks associated with a subsequent ESBL infection to help inform empiric antibiotic decisions.

Methods:
A retrospective cohort study of adult patients with positive index culture for Escherichia coli or Klebsiella pneumoniae (EC/KP) receiving medical care during 2017 was conducted. Risk assessments were performed to identify factors associated with subsequent infection caused by ESBL-producing EC/KP.

Results:
In total, 200 patients were included in the cohort, 100 with ESBL-producing EC/KP and 100 with ESBL-negative EC/KP. Of 100 patients (50%) who developed a subsequent infection, 22 infections were ESBL-producing EC/KP, 43 were other bacteria, and 35 had no or negative cultures. Subsequent infection caused by ESBL-producing EC/KP only occurred when the index culture was also ESBL-producing (22 vs 0). Among those with ESBL-producing index culture, the incidences of subsequent infection caused by ESBL-producing EC/KP versus other bacterial subsequent infection were similar (22 vs 18; P = .428). Factors associated with subsequent infection caused by ESBL-producing EC/KP include history of ESBL-producing index culture, time ≤180 days between index culture and subsequent infection, male sex, and Charlson comorbidity index score >3.

Conclusions:
History of ESBL-producing EC/KP culture is associated with subsequent infection caused by ESBL-producing EC/KP, particularly within 180 days after the historical culture. Among patients presenting with infection and a history of ESBL-producing EC/KP, other factors should be considered in making empiric antibiotic decisions, and ESBL-targeted therapy may not always be warranted.