bluuebunny/crossref_metadata_2025_split huggingface dataset:
Survival after resection of brain metastasis: impact of synchronous versus metachronous metastatic disease
Authors: Potthoff Anna-Laura , Heimann Muriel , Lehmann Felix , Ilic Inja , Paech Daniel , Borger Valeri , Radbruch Alexander , Schäfer Niklas , Schuss Patrick , Vatter Hartmut , Herrlinger Ulrich , Schneider Matthias 
Published: January 2023

Abstract
Purpose
Patients with brain metastasis (BM) from solid tumors are in an advanced stage of cancer. BM may occur during a known oncological disease (metachronous BM) or be the primary manifestation of previously unknown cancer (synchronous BM). The time of diagnosis might decisively impact patient prognosis and further treatment stratification. In the present study, we analyzed the prognostic impact of synchronous versus (vs.) metachronous BM occurrence following resection of BM.

Methods
Between 2013 and 2018, 353 patients had undergone surgical therapy for BM at the authors’ neuro-oncological center. Survival stratification calculated from the day of neurosurgical resection was performed for synchronous vs. metachronous BM diagnosis.

Results
Non-small-cell lung carcinoma (NSCLC) was the most common tumor entity of primary site (43%) followed by gastrointestinal cancer (14%) and breast cancer (13%). Synchronous BM occurrence was present in 116 of 353 patients (33%), metachronous BM occurrence was present in 237 of 353 patients (67%). NSCLC was significantly more often diagnosed via resection of the BM (56% synchronous vs. 44% metachronous situation, p = 0.0001). The median overall survival for patients with synchronous BM diagnosis was 12 months (95% confidence interval (CI) 7.5–16.5) compared to 13 months (95% CI 9.6–16.4) for patients with metachronous BM diagnosis (p = 0.97).

Conclusions
The present study indicates that time of BM diagnosis (synchronous vs. metachronous) does not significantly impact patient survival following surgical therapy of BM. These results suggest that the indication for neurosurgical BM resection should be made regardless of a synchronous or a metachronous time of BM occurrence.
Equal marriage rights and the European Courts
Authors: Shahid Masuma 
Published: January 2023

AbstractThe legalisation of same-sex marriage has taken off globally in the last thirty years, especially in Europe; thirty-three countries around the world, nineteen of which are in Europe, have opened up civil marriage to same-sex couples. The Court of Justice of the European Union (CJEU) and the European Court of Human Rights (ECtHR) have also had their share of equal marriage rights cases before them to decide upon. This contribution discusses the role the two European courts have played in this field and how their case law has developed, in somewhat parallel stages, throughout the years.
Concomitant fractures in patients with proximal femoral fractures lead to a prolonged hospital stay but not to increased complication rates or in-house mortality if treated surgically: a matched pair analysis
Authors: Fenwick Annabel , Pfann Michael , Mayr Jakob , Antonovska Iana , Von der Helm Franziska , Nuber Stefan , Förch Stefan , Mayr Edgar 
Published: January 2023

Abstract
Background
Impact of concomitant fractures on patients sustaining a proximal femur fracture remains unclear. Rising numbers and patient need for rehab is an important issue. The objective of our study was to investigate the impact of concomitant fractures, including all types of fractures, when treated operatively, for proximal femur fractures on the length of hospital stay, in-house mortality and complication rate.

Methods
Observational retrospective cohort single-center study including 85 of 1933 patients (4.4%) with a mean age of 80.5 years, who were operatively treated for a proximal femoral and a concomitant fracture between January 2016 and June 2020. A matched pair analysis based on age, sex, fracture type and anticoagulants was performed. Patient data, length of hospital stay, complications and mortality were evaluated.

Results
The most common fractures were osteoporosis-associated fractures of the distal forearm (n = 34) and the proximal humerus (n = 36). The group of concomitant fractures showed a higher CCI than the control group (5.87 vs. 5.7 points; p < 0.67). Patients with a concurrent fracture had a longer hospital stay than patients with an isolated hip fracture (15.68 vs. 13.72 days; p < 0.056). Complications occurred more often in the group treated only for the hip fracture (11.8%, N = 20), whilst only 7.1% of complications were recorded for concomitant fractures (p < 0.084). The in-house mortality rate was 2.4% and there was no difference between patients with or without a concomitant fracture.

Conclusions
A concomitant fracture to a hip fracture increases the length of hospital stay significantly but does not increase the complication rate or the in-house mortality. This might be due to the early mobilization, which is possible after early operative treatment of both fractures.
A two-stage adaptive penalty method based on co-evolution for constrained evolutionary optimization
Authors: Wang Bing-Chuan , Guo Jing-Jing , Huang Pei-Qiu , Meng Xian-Bing 
Published: January 2023

AbstractPenalty function method is popular for constrained evolutionary optimization. However, it is non-trivial to set a proper penalty factor for a constrained optimization problem. This paper takes advantage of co-evolution to adjust the penalty factor and proposes a two-stage adaptive penalty method. In the co-evolution stage, the population is divided into multiple subpopulations, each of which is associated with a penalty factor. Through the co-evolution of these subpopulations, the performance of penalty factors can be evaluated. Since different penalty factors are used, the subpopulations will evolve along different directions. Thus, exploration can be enhanced. In the shuffle stage, all subpopulations are merged into a population and the best penalty factor from the co-evolution stage is used to guide the evolution. In this manner, the information interaction among subpopulations can be facilitated; thus, exploitation can be promoted. By executing these two stages iteratively, the feasible optimum could be obtained finally. In the two-stage evolutionary process, the search algorithm is designed based on two trial vector generation strategies of differential evolution. Additionally, a restart mechanism is designed to help the population avoid stagnating in the infeasible region. Extensive experiments demonstrate the effectiveness of the proposed method.
Chinese Investment in Malaysia: COVID-19, Democracy and Beyond
Authors: Chen Vivien , Chen Weitseng 
Published: January 2023

AbstractChina's rising influence in parts of the developing world has raised concerns among the US and its allies. In the wake of the COVID-19 outbreak, the provision of vaccines and aid to countries in the Global South have further heightened anxieties over the potential for diffusion of China's ideals. China's investments are thought to promote the diffusion of its perspectives of rule of law and democracy, posing a challenge to the global dominance of Western liberal democratic values. Nonetheless, few studies have examined how the diffusion of China's ideals may occur through its investments and infrastructure projects in young democracies such as Malaysia whose governance and legal system significantly outperform China's according to various global indexes. This article investigates the increasing engagement with China and the reasons for this trend against the backdrop of Malaysia's legal and political institutions inherited from the West. It considers how young democracies like Malaysia are vulnerable to China's influence, intentional or unintentional, through investment. The analysis sheds light on the mechanisms that give rise to such vulnerability, exploring how the electoral system and rule of law may facilitate and amplify the impact of Chinese investment, with broader implications. Shared tacit understandings, such as the instrumentality of law and the nexus between state and business, which facilitate cross-country cooperation are also examined.
The EU Vaccines Strategy: A Missed Opportunity for EU Public Health?
Authors: Della Corte Francesco Saverio 
Published: January 2023

AbstractThe response to the COVID-19 crisis implied an unprecedented involvement of the European Union (EU) executive in public health matters. In June 2020, the Member States agreed upon a joint EU Vaccines Strategy, whereby the European Commission was enabled to negotiate, support and allocate vaccine doses on their behalf. Entailing political and redistributive choices, the Commission’s centralised procurement presents some innovative patterns when compared to traditional EU executive action. This paper will focus on the institutionalisation of such patterns within the legal framework of the Health Emergency Preparedness and Response Authority (HERA). Did EU administrative law offer appropriate tools for this process? Or did the EU merely formalise the procedural and organisational schemes set up during the crisis? Answers to these questions will contribute to a fuller understanding of the administrative dimension of the new European Health Union and shed light on some recent evolutions of the EU administrative system.
Effects of haptic imagery on purchase intention
Authors: Inoue Yumi 
Published: January 2023

Abstract
The COVID‑19 pandemic has increased the popularity of online shopping, and companies are looking for ways to provide consumers with experiences that online shopping cannot provide, such as touching products and imagining them in use. In this context, the importance of haptic imagery of products showcased online is increasing. This study replicated and extended Peck et al.’s (2013, Journal of Consumer Psychology, 23, 189–196) finding that physical control and psychological ownership mediate the influence of haptic imagery on purchase intention. This study showed that imagining touching a product increased purchase intention through the mediation of physical control and psychological ownership compared with not imagining, conceptually replicating Peck et al.’s study. This study also examined the moderating effect of product involvement and showed that there was no moderator role of product involvement. The findings would have a practical application in marketing, such as encouraging consumers to imagine touching the product.
“Goodbye Mshatta”: Connections and Disconnections on Berlin's Museum Island
Authors: Puzon Katarzyna 
Published: January 2023

AbstractThis essay is concerned with a contemporary art intervention in Berlin's Museum of Islamic Art, in the context of the Mshatta Façade's move. Sketching out Mshatta's relocation history, the essay highlights how the dynamic of connection and disconnection plays out in a museum setting and is embedded in epistemic concepts mobilized in knowledge-making about objects. Specifically, it focuses on an installation entitled “Goodbye Mschatta. Ich bin ein Fremder. Zweifach Fremder” (“Goodbye Mshatta. I Am a Stranger: Twofold a Stranger”), by a Syrian-born German visual artist who was commissioned to bid farewell to the Façade in its most recent location before it moves to the Pergamon Museum's north wing. Entering into a dialogue with Mshatta, his sculptural intervention pivoted around the themes of incompleteness, mélange, and in-betweenness. It revealed multiple connections and disconnections with regard to the Façade’s biography, while ostensibly disengaging from the debate on historical justice and imperial legacies.
Reference growth curves to identify weight status (underweight, overweight or obesity) in children and adolescents: systematic review
Authors: Alves Junior Carlos Alencar Souza , Martins Priscila Custódio , Moreno Aznar Luis Alberto , Silva Diego Augusto Santos 
Published: January 2023

AbstractThe identification of somatic growth, through reference curves, can be used to create strategies and public policies to reduce public health problems such as malnutrition and obesity and to identify underweight, overweight and obesity. The purpose of this systematic review was to identify studies providing reference growth curves for weight status in children and adolescents. A systematic search was conducted in eight databases and in gray literature (Google scholar). To assess the risk of bias/methodological quality of studies, the National Institutes of Health (NIH) Quality Assessment Tool for Observational Cohort and Cross-sectional Studies (NHLBI) was used. Overall, 86 studies that met the inclusion criteria were included. Through the values of reference growth curves for the identification of underweight, overweight and obesity, it was possible to verify that there is great variability among percentiles for the identification of underweight, overweight and obesity. The most prevalent percentiles for underweight were P3 and P5; for overweight, the most prevalent was P85 and the most prevalent percentiles for obesity were P95 and P97. The most prevalent anthropometric indicators were Body Mass Index (BMI), Waist Circumference (WC), Body Mass (BM) for age and height for age. Conclusion: Such data can demonstrate that the optimal growth must be reached, through the standard growth curves, but that the reference curves demonstrate a cut of the population growth, raising possible variables that can influence the optimal growth, such as an increase in the practice of physical activities and an awareness of proper nutrition.
When Censorship Works: Exploring the Resilience of News Websites to Online Censorship
Authors: Lutscher Philipp M. 
Published: January 2023

AbstractTo what degree are news websites in autocracies resilient to online censorship? I explore this question in Egypt, which has begun to heavily censor news websites in recent years, alongside several other autocracies. Relying on a sample of 145 news outlets, I systematically explore how blocking affects traffic on outlets and their current statuses. Statistical tests show that blocked Egyptian outlets lost on average 54–55 per cent of their global traffic and are more likely to halt their activity. Heterogeneity analyses reveal that the loss in traffic was particularly strong for independent, Islamist opposition and larger outlets, and that permanently blocked websites were substantially more likely to halt services. These results support previous work on state repression and information control showing that censorship often works in reducing the consumption and provision of alternative political information.
Gender-Based Violence Research in Canadian Political Science: A Call to Action
Authors: Collier Cheryl N. 
Published: January 2023

AbstractGender-based violence is a prevalent and persistent societal problem in Canada that permeates all spaces, including politics. Yet sexual harassment, sexual assault and/or gender-based violence research is rarely found in mainstream political science in Canada or elsewhere. This article argues that this absence is highly problematic for a discipline that purports to centre itself on understanding power—who has it and who doesn't, and how to access it. It further argues for a normative intersectional and interdisciplinary approach, highlighting promising avenues of research in feminist institutionalism and Indigenous feminism to help achieve elusive solutions to gender-based violence in the future.
Cost-effectiveness of transdiagnostic group cognitive behavioural therapy for anxiety disorders v. treatment as usual: economic evaluation of a pragmatic randomized controlled trial over an 8-month time horizon using self-reported data
Authors: Chapdelaine Alexandra , Vasiliadis Helen-Maria , Provencher Martin D. , Norton Peter J. , Roberge Pasquale 
Published: January 2023

AbstractBackgroundThis economic evaluation supplements a pragmatic randomized controlled trial conducted in community care settings, which showed superior improvement in the symptoms of adults with anxiety disorders who received 12 sessions of transdiagnostic cognitive-behavioural group therapy in addition to treatment as usual (tCBT + TAU) compared to TAU alone.MethodsThis study evaluates the cost-utility and cost-effectiveness of tCBT + TAU over an 8-month time horizon. For the reference case, quality-adjusted life years (QALYs) obtained using the EQ-5D-5L, and the health system perspective were chosen. Alternatively, anxiety-free days (AFDs), derived from the Beck Anxiety Inventory, and the limited societal perspective were considered. Unadjusted incremental cost-effectiveness/utility ratios were calculated. Net-benefit regressions were done for a willingness-to-pay (WTP) thresholds range to build cost-effectiveness acceptability curves (CEAC). Sensitivity analyses were included.ResultsCompared to TAU (n = 114), tCBT + TAU (n = 117) generated additional QALYs, AFDs, and higher mental health care costs from the health system perspective. From the health system and the limited societal perspectives, at a WTP of Can$ 50 000/QALY, the CEACs showed that the probability of tCBT + TAU v. TAU being cost-effective was 97 and 89%. Promising cost-effectiveness results using AFDs are also presented. The participation of therapists from the public health sector could increase cost-effectiveness.ConclusionsFrom the limited societal and health system perspectives, this first economic evaluation of tCBT shows favourable cost-effectiveness results at a WTP threshold of Can$ 50 000/QALY. Future research is needed to replicate findings in longer follow-up studies and different health system contexts to better inform decision-makers for a full-scale implementation.
Wisdom and methodological diversity in philosophy of religion
Authors: O'Grady Paul 
Published: January 2023

AbstractThere exists wide methodological diversity in philosophy of religion and many of the ways of responding to it are inadequate. This article argues that resources from virtue epistemology can help respond better, specifically connecting the issue to the notion of wisdom. A framework for this is articulated and then applied to Aquinas and Wittgenstein, chosen as utilizing starkly different methodologies in dealing with problems from philosophy of religion.
A philosophical perspective about the origin, evolution and distribution of life in the Universe
Authors: Nascimento-Dias Bruno Leonardo do 
Published: January 2023

AbstractThe main idea is to present the general aspects of the origin, evolution and distribution of life in the Universe from a Philosophy of Science perspective. The methodology used to develop this paper was through the intersection of favourable and unfavourable arguments from practitioners of science in the field of modern Astrobiology. The results were quite interesting and the historical crossover between the different arguments provides a great perspective on the research programme for the search for extraterrestrial life. Finally, although there is in fact no evidence that extraterrestrial life exists, the search for extraterrestrial life should not be considered as mere speculation. In the end, there are increasing indications that something extraordinary may be about to be found, whether on Mars, Europa, Enceladus or on some exoplanet.
Joint Analysis of Seismic and Electrical Observables Beneath the Central Appalachians Requires Partial Melt in the Upper Mantle
Authors: Mittal Ved , Long Maureen D. , Evans Rob L. , Byrnes Joseph S. , Bezada Maximiliano 
Published: January 2023

AbstractThe Central Appalachian Anomaly (CAA) is a region of the upper mantle beneath eastern North America that exhibits pronounced anomalies in its seismic velocity, seismic attenuation, and electrical conductivity structure. The CAA clearly expresses itself in low velocity, high attenuation, and high conductivity values; however, the present‐day composition and state of the asthenospheric upper mantle in the anomalous region remains imperfectly known. The collection of data from densely spaced, co‐located seismic and magnetotelluric arrays during the Mid‐Atlantic Geophysical Integrative Collaboration (MAGIC) experiment affords the opportunity to probe the structure and properties of the upper mantle in the CAA region in detail using multiple types of geophysical observations. Here, we present new observations of P and S wave travel times from teleseismic earthquakes measured at MAGIC stations, including a determination of how travel times deviate from the predictions of a standard 1‐D reference model. These observations constrain the ratio of the P to S wave travel time perturbations associated with the CAA, which in turn allows us to estimate the ratio of P and S wave velocity anomalies. We combine these observations with previously published estimates of seismic attenuation and electrical conductivity in the upper mantle beneath the MAGIC array, and carry out forward modeling to determine reasonable ranges of temperature, partial melt fraction, water content, and composition for the CAA. Our results suggest that 1%–2% partial melt is required to simultaneously explain the velocity, attenuation, and electrical conductivity observations beneath the MAGIC array.
The Stratosphere‐Ionosphere‐Protonosphere Coupling: Evidence From the Ion Composition Observations During the 2009 Sudden Stratospheric Warming
Authors: Zhang Ruilong , Liu Libo , Chen Yiding , Le Huijun , Li Wenbo 
Published: January 2023

AbstractPrevious studies suggested that sudden stratospheric warmings (SSW) change the global atmosphere from troposphere to thermosphere/ionosphere. We report the low‐latitude O+ and H+ composition at 840‐km altitude during the 2009 SSW, with the DMSP satellite morning measurements. Our results indicate that the stratospheric variation around 30‐km altitude modulates the ion exchange between the ionosphere and protonosphere via the vertical and field‐aligned plasma drifts due to the enhanced lunar semidiurnal tides. The upward disturbance drift uplifts the ionospheric O+ into the protonosphere, and most O+ is changed to H+ via chemical coupling, while the O+/H+ transition height does not change under combined effects of the southward and upward disturbance drifts on 24–29 January. The disturbance drift turns downward, lowers the O+/H+ transition height, depletes the O+ density in the protonosphere, and the H+ at higher altitudes moves downward to supply the H+ at 840 km from 30 January to 5 February.