bluuebunny/crossref_metadata_2025_split huggingface dataset:
The compassionate journey: An exploratory and controlled study assessing self‐compassion‐focussed mindfulness in a nonclinical sample
Authors: Yeshua Maor , Zohar Ada H. 
Published: July 2023

AbstractThe purpose of the current study was to test a self‐compassion‐focussed mindfulness (SCFM) intervention for increasing self‐compassion and decreasing depressive symptoms, as well as to test the effect of initial self‐compassion as a possible moderator. Community volunteers participated in an SCFM group or in a control group and self‐reported at three points in time: at baseline (study, n = 73; control, n = 80), at the end of the 5‐week five‐session intervention (study, n = 57; control, n = 61) and at follow‐up 5 weeks later (study, n = 47; control, n = 50). The SCFM was a Hebrew adaptation based on a mindful self‐compassion programme, which is available online. The SCFM was held in person, in small groups (N < 20) over a 2‐month period. A four‐way interaction was found to be significant [F(2, 186) = 3.70, p = 0.027, η2p = 0.038]. Post hoc tests showed that those who were initially low on self‐compassion and participated in the SCFM experienced relief in their depressive symptoms and that their level of self‐compassion was increased. This implies that self‐compassion is a moderating trait, with the benefit of relieving suffering. By increasing the levels of self‐compassion in individuals, it is possible to improve their psychological health.
The role of dark pattern stimuli and personality in online impulse shopping: An application of S‐O‐R theory
Authors: Abbott Rebecca , Sin Ray , Pedersen Christian , Harris Ted , Beck Talia , Nilsson Simon , Dong Tracy , Wang Yi , Li Yue 
Published: July 2023

AbstractOnline impulse shopping is a growing industry. This paper uses the Stimulus‐Organism‐Response framework to model online impulse purchase behavior using a novel combination of stimuli and organism characteristics. The stimuli: social proof, limited‐quantity scarcity, and high‐demand, are three commonly used website features known as dark patterns. The organism characteristic personality is measured by the big 5 personality traits and persona generated through latent profile analysis. Using the machine learning algorithm XGBoost, impulse purchasing response was predicted separately for each dark pattern stimuli. Results show personality characteristics are important features when predicting consumer impulse purchasing in response to dark pattern messages. Moreover, the personality traits (and personas) most predictive of impulse shopping behavior varied by type of dark pattern. Findings suggest personality influences susceptibility to different dark patterns, indicating a need for tailored interventions to mitigate individual consumer vulnerabilities to impulse shopping.
More than just mild thrombocytopenia: Clinical clues in the diagnosis of germline predisposition to malignancy from a rare ETV6 variant
Authors: Fang Shannon , Botero Juliana Perez , Hackney Lisa R. 
Published: July 2023

Key Clinical MessageIn the evaluation of patients with longstanding mild thrombocytopenia, emphasis on family history, genetic testing, and collaborative clinical and laboratory‐based family studies can ensure proper diagnosis and monitoring for malignancies.AbstractWe report the diagnostic approach to mild and non‐specific thrombocytopenia with unclear genetic findings in two sisters. Genetic sequencing revealed a rare variant in ETS Variant Transcription Factor 6, which is associated with inherited thrombocytopenia with predisposition to hematologic malignancy. Familial studies provided sufficient evidence for a likely pathogenic classification.
Chylous ascites as a rare complication of abdominal trauma in a 7‐year‐old girl: A case report
Authors: Jafari Anahita , Reihani Hamid , Karbasian Fereshteh , Darban Behnaz , Dehghani Seyed Mohsen 
Published: July 2023

Key Clinical MessageAbdominal trauma can be one of the causes of chylous ascites in pediatric cases, along with tuberculosis and malignancy. However, a definitive diagnosis is more reasonable to be done by excluding other causes.AbstractChylous ascites (CA) is a rare type of ascites. Though it has high mortality and morbidity rates, which usually happen due to the rupture of lymph vessels into the peritoneal cavity. Congenital abnormalities, including lymphatic hypoplasia or dysplasia, are the most causes in pediatrics. CA following trauma in children is very rare, and to the best of our knowledge, there are very few reports in this regard. Here, we report a 7‐year‐old girl who was referred to our center with CA after a car accident.
Bifid cardiac apex and spongiform cardiomyopathy in fetus with small microdeletion 16p12.2 of paternal origin. Critical points in family communication on 16p12.2 microdeletion
Authors: Stabile Mariano , Rispoli Anna F. , Capuozzo Maurizio , Ferbo Umberto , Stabile Guglielmo 
Published: July 2023

Key Clinical MessageFrom a literature review, this is the first case of fetal 16p12.2 microdeletion syndrome inherited from a normal father with autopsy description and evidence of spongious cardiomyopathy. First trimester intake of doxycycline could be a cofactor.AbstractPrenatal diagnosis of a 16p12.2 microdeletion, inherited from normal father, is reported in a dysmorphic 20 weeks fetus. Histopathological examination of the myocardium (not present in the 65 cases in literature) showed bifid apex of the heart and spongiotic structure. Correlation between the deleted genes and cardiomyopathy is discussed.
Spontaneous bacterial peritonitis complicating extensive splanchnic vein thrombosis, a rare manifestation of essential thrombocythemia: A case report
Authors: Agrawal Saurav , Rayamajhi Sandesh , Rayamajhi Aadesh , Karki Susmin , Deo Anand , Kharel Kirti Kala , Lamsal Manoj , Hamal Rabin 
Published: July 2023

Key Clinical MessageClinicians should be mindful of the rare occurrence of spontaneous bacterial peritonitis in essential thrombocythemia with extensive splanchnic vein thrombosis, especially when patients with ascites exhibit fever and abdominal pain.AbstractSpontaneous bacterial peritonitis (SBP) complicating extensive splanchnic vein thrombosis (SVT) is a rare manifestation of essential thrombocythemia (ET). In the absence of any hypercoagulable state, JAK2 mutation can be an important risk factor for extensive SVT. Evaluation for SBP is crucial when non‐cirrhotic patient exhibits fever, abdominal pain and tenderness in the background of ascites after ruling out common pathologies such as tubercular peritonitis, acute pancreatitis, Budd‐Chiari syndrome and ovarian malignancy. We present a case of SBP complicating pre‐hepatic portal hypertension with ascites in a 44‐years‐old female. On further evaluation, extensive SVT with portal cavernoma in the setting of ET was identified. She was managed with cytoreductive therapy and anticoagulation, resulting in symptom resolution.
Cancer‐associated fibroblast expression of glutamine fructose‐6‐phosphate aminotransferase 2 (GFPT2) is a prognostic marker in gastric cancer
Authors: Yang Shuo , Li Guoli , Yin Xin , Wang Yufei , Jiang Xinju , Bian Xiulan , Fang Tianyi , Yin Shengjie , Zhang Lei , Xue Yingwei 
Published: July 2023

AbstractGlutamine fructose‐6‐phosphate aminotransferase 2 (GFPT2) is a rate‐limiting enzyme in hexosamine biosynthesis involved in the occurrence and progress of many cancers. What role it plays in gastric cancer (GC) is still unclear. In this study, transcriptome sequencing data from the Harbin Medical University (HMU)‐GC cohort and The Cancer Genome Atlas (TCGA) dataset were combined with the HMU‐TCGA training cohort to analyze the biological function and clinical significance of GFPT2. The correlation of GFPT2 with immune cells and stromal cells was analyzed in the GC immune microenvironment through transcriptome sequencing data and a public single‐cell sequencing database. In cell lines, GC tissues, and the tissue microarray, GFPT2 protein expression was confirmed by western blotting and immunohistochemistry. The mRNA of GFPT2 was highly expressed in the tumor (p < 0.001), and GC cells and tumors expressed high levels of GFPT2 protein. Compared to low expression, high GFPT2 mRNA expression was associated with higher levels of tumor invasion, higher pathological stages, and poor prognosis (p = 0.02) in GC patients. In a drug susceptibility analysis, GFPT2 mRNA expression was associated with multiple chemotherapeutic drug sensitivity, including docetaxel, paclitaxel, and cisplatin. Gene enrichment analysis found that GFPT2 was mainly primarily involved in the extracellular matrix receptor interaction pathway. The ESTIMATE, CIBERSORT, and ssGSEA algorithms showed that GFPT2 was associated with immune cell infiltration. In addition, GFPT2 was more likely to be expressed within cancer‐associated fibroblasts (CAFs), and high levels of GFPT2 expression were highly correlated with four CAFs scores (all p < 0.05). Finally, a prognostic model to assess the risk of death in GC patients was constructed based on GFPT2 protein expression and lymph node metastasis rate. In conclusion, GFPT2 plays an essential role in the function of CAFs in GC. It can be used as a biomarker to assess GC prognosis and immune infiltration.
Race, ethnicity, and experienced racism are associated with adverse physical and mental health outcomes among cancer survivors
Authors: Karvonen Kristine A. , Balay‐Dustrude Erin , Do Annie , Bradford Miranda C. , Phipps Amanda , Rosenberg Abby R. 
Published: July 2023

AbstractIntroductionSurvivors of cancer are at risk for adverse mental and physical health outcomes. It is not well understood, however, how these outcomes are differentially experienced according to an individual’s exposure to racism. This study sought to evaluate associations of race/ethnicity, and experiences of racism, with adverse health outcomes in survivors of cancer.MethodsUsing the Behavioral Risk Factor Surveillance System database, data from 48,200 survivors between 2014 and 2020 were evaluated. Survey items included negative physical and emotional symptoms as a result of race‐based treatment. Outcomes of interest included days of poor mental and physical health, activity limitations, depression, and inadequate sleep. Associations using prevalence ratios were evaluated.ResultsAll historically marginalized racial/ethnic groups were more likely to experience at least one adverse health outcome compared with non‐Hispanic White survivors. Those who physically experienced racism were 2.1 (95% CI, 1.64–2.69) times as likely to report poor physical health, 3.51 (95% CI, 2.61–4.71) times as likely to report poor mental health, 2.14 (95% CI, 1.77–2.58) times as likely to report inadequate sleep, 2.33 (95% CI: 1.91–2.83) times as likely to report depression, and 1.42 (95% CI, 1.04–1.93) times as likely to report activity limitations compared with those who have not experienced racism. Similar associations were observed for emotionally experienced racism.DiscussionRacial inequities in health outcomes for survivors of cancer from marginalized racial/ethnic groups are well‐established. Experienced racism contributes to adverse health outcomes and widens these disparities. Improving outcomes for survivors of cancer may require screening for experienced racism.Plain Language Summary

Survivors of cancer from marginalized racial/ethnic populations are more likely to have poor mental and physical health than their non‐Hispanic White counterparts. Whether survivors from certain racial/ethnic populations of smaller size also have poorer health is less well understood.

Generally, individuals who report experienced racism also report poor health, this association has not been studied in survivors of cancer.

This study, from a national survey of survivors of cancer, describes disparities in health outcomes experienced by a variety of racial and ethnic populations. Our findings suggest racism is associated with poor mental and physical health in survivors of cancer.
A phase 2 study of neoadjuvant chemotherapy plus durvalumab in resectable locally advanced head and neck squamous cell carcinoma
Authors: Patel Shetal A. , Gibson Michael K. , Deal Allison , Sheth Siddharth , Heiling Hillary , Johnson Steven M. , Douglas Kathe , Flores Melissa , Blumberg Jeffrey , Lumley Catherine , Yarbrough Wendell G. , Shen Colette , Chera Bhishamjit S. , Bauman Jessica R. , Hackman Trevor , Weiss Jared 
Published: July 2023

AbstractBackgroundPatients with locally advanced head and neck squamous cell cancer (HNSCC) are treated with surgery followed by adjuvant (chemo) radiotherapy or definitive chemoradiation, but recurrence rates are high. Immune checkpoint blockade improves survival in patients with recurrent/metastatic HNSCC; however, the role of chemo‐immunotherapy in the curative setting is not established.MethodsThis phase 2, single‐arm, multicenter study evaluated neoadjuvant chemo‐immunotherapy with carboplatin, nab‐paclitaxel, and durvalumab in patients with resectable locally advanced HNSCC. The primary end point was a hypothesized pathologic complete response rate of 50%. After chemo‐immunotherapy and surgical resection, patients received study‐defined, pathologic risk adapted adjuvant therapy consisting of either durvalumab alone (low risk), involved field radiation plus weekly cisplatin and durvalumab (intermediate risk), or standard chemoradiation plus durvalumab (high risk).ResultsBetween December 2017 and November 2021, 39 subjects were enrolled at three centers. Oral cavity was the most common primary site (69%). A total of 35 of 39 subjects underwent planned surgical resection; one subject had a delay in surgery due to treatment‐related toxicity. The most common treatment‐related adverse events were cytopenias, fatigue, and nausea. Post treatment imaging demonstrated an objective response rate of 57%. Pathologic complete response and major pathologic response were achieved in 29% and 49% of subjects who underwent planned surgery, respectively. The 1‐year progression‐free survival was 83.8% (95% confidence interval, 67.4%–92.4%).ConclusionsNeoadjuvant carboplatin, nab‐paclitaxel, and durvalumab before surgical resection of HNSCC were safe and feasible. Although the primary end point was not met, encouraging rates of pathologic complete response and clinical to pathologic downstaging were observed.
Detecting the birth and death of finite‐time coherent sets
Authors: Froyland Gary , Koltai Péter 
Published: July 2023

AbstractFinite‐time coherent sets (FTCSs) are distinguished regions of phase space that resist mixing with the surrounding space for some finite period of time; physical manifestations include eddies and vortices in the ocean and atmosphere, respectively. The boundaries of FTCSs are examples of Lagrangian coherent structures (LCSs). The selection of the time duration over which FTCS and LCS computations are made in practice is crucial to their success. If this time is longer than the lifetime of coherence of individual objects then existing methods will fail to detect the shorter‐lived coherence. It is of clear practical interest to determine the full lifetime of coherent objects, but in complicated practical situations, for example a field of ocean eddies with varying lifetimes, this is impossible with existing approaches. Moreover, determining the timing of emergence and destruction of coherent sets is of significant scientific interest. In this work we introduce new constructions to address these issues. The key components are an inflated dynamic Laplace operator and the concept of semi‐material FTCSs. We make strong mathematical connections between the inflated dynamic Laplacian and the standard dynamic Laplacian, showing that the latter arises as a limit of the former. The spectrum and eigenfunctions of the inflated dynamic Laplacian directly provide information on the number, lifetimes, and evolution of coherent sets.
Psychologists' and psychotherapists' knowledge, attitudes, and clinical practices regarding the therapeutic use of psychedelics
Authors: Kucsera Aileen , Suppes Trisha , Haug Nancy A. 
Published: July 2023

AbstractIntroductionThis study explored the current knowledge, attitudes, and clinical practices regarding psychedelics among mental health professionals in California, where state legislation to decriminalize psychedelics has been proposed.MethodTwo hundred thirty‐seven mental health providers (74% female; mean age 54; 83% White; 46% psychologists) completed a 37‐item online survey between November 2021 and February 2022, disseminated through local and state‐wide professional organizations in California.ResultsProviders endorsed limited knowledge about the risks and benefits of psychedelic use (M = 4.7 and 5.4, respectively, with 10 = high knowledge) and inadequate knowledge to counsel patients on use (45%). Gaps in knowledge related to psychedelic drug scheduling and current use in clinical research were identified. Providers expressed support for additional psychedelic research (97%), approval of recreational (66%) and medical (91%) psychedelic use, belief in the potential therapeutic benefits of psychedelics (89%), and concerns about safety (33%) and potential psychiatric risks (27%). Results indicated that most providers discuss psychedelic use with patients (73%), yet many do not feel comfortable addressing the effects of use (49%). There were significant correlations between knowledge and attitudes towards psychedelics (r = 0.2, p = .006; r = 0.31, p < .001) and attitudes and clinical practices (r = 0.34, p < .001).ConclusionsFindings suggest that providers are interested in psychedelic‐assisted treatments and hold favourable attitudes towards the therapeutic use of psychedelics yet lack the knowledge to appropriately counsel patients, highlighting the need for additional provider education about psychedelics.
Isolation of Genomic DNA from Mammalian Cells and Fixed Tissue
Authors: Miskimen Kristy L. S. , Miron Penelope L. 
Published: July 2023

AbstractExamination of DNA variation is central to understanding the function of mammalian cells, tissues, and whole bodies. Extraction of high‐quality DNA from cells and tissues is necessary for innumerable different experiments. We present protocols for the extraction of DNA from both fresh samples and formalin‐fixed tissue. Methods for extracting DNA have been standardized and streamlined over the past couple of decades and many extraction kits are available for a reasonable cost. In addition, many of the extraction procedures can also be automated for even higher throughput sample preparation. © 2023 The Authors. Current Protocols published by Wiley Periodicals LLC.Basic Protocol 1: DNA isolation from whole blood, tissue, and cultured cellsAlternate Protocol: DNA extraction using automated machinesBasic Protocol 2: DNA isolation from saliva and buccal swabsBasic Protocol 3: DNA isolation from formalin‐fixed, paraffin‐embedded tissue
Identification of solvent retention capacity quantitative trait loci by combined linkage and association mapping in wheat (Triticum aestivum L.)
Authors: Xiao‐ling Jiang , Hong‐min Li , Yu‐ling An , Ji‐shun Zhao , Yan‐yan Geng , Xiao‐jun Li , Qing‐yun Guan , Mei‐ling Yan , Ji‐chun Tian , Jian‐sheng Chen 
Published: July 2023

AbstractSolvent retention capacity (SRC) is an important tool for assessing wheat quality by estimating the biochemical characteristics of flour components. Although it has been widely used in wheat breeding programs, its genetic architecture is still poorly understood. Hence, the objective of this study was to find quantitative trait loci (QTLs) associated with four SRC traits, namely sucrose SRC, sodium carbonate SRC, water SRC and lactic acid SRC, in a recombinant inbred line population consisting of 173 lines descended from Shannong 01–35/Gaocheng 9411 and an association panel of 205 wheat varieties. The 90K single nucleotide polymorphism array was used to genotype both populations. SRC was primarily influenced by genotype, with broad‐sense heritability (H2) ranging from 59.72% to 80.76%. Linkage mapping revealed seven major QTLs on chromosomes 1B, 4B, 5B, and 6B. Among them, QSc1B.6‐27 was repeatedly identified in two different environments, with a 14.7% phenotypic variance explained value. Additionally, 24 significant QTLs, consisting of 57 marker‐trait associations, were identified using association mapping across four environments. Nineteen of them explained more than 10.0% of the phenotypic variance, with QSU6A.141 explaining the most (20.1%). Two common chromosomal regions were discovered when combining the two mapping populations. These regions were located between IACX5803 and BS00067000_51 on chromosome 1B and between IACX557 and CAP11_c3631_75 on chromosome 4B, respectively. In addition, four candidate genes associated with wheat SRC were identified. These findings shed light on the complex genetic mechanisms underlying wheat SRC and may help to genetically enhance wheat quality.
Is breakfast consumption detrimental, unnecessary, or an opportunity for health promotion? A review of cardiometabolic outcomes and functional food choices
Authors: Santos Heitor O. , Tinsley Grant M. 
Published: July 2023

AbstractBreakfast consumption is generally considered a health‐promoting habit for cardiometabolism, particularly with regard to chrononutrition. Glucose uptake is enhanced by proper insulin secretion triggered by the pancreatic clock, averting metabolic dysregulation related to insulin resistance. Breakfast skipping, in turn, is often considered a behaviour detrimental to health, in part due to putative inverse metabolic actions compared to breakfast consumption, such that breakfast skipping may promote circadian desynchrony. However, most ill health concerns about breakfast skipping are inferred from observational research, and recent well‐controlled randomized clinical trials have shown benefits of breakfast skipping for cardiovascular risk factors. Accordingly, this review describes the effects of breakfast consumption versus breakfast skipping on cardiovascular risk factors (blood pressure and glycaemic and lipid indices). In addition, the view of breakfast consumption as an opportunity for functional food ingestion is considered to provide further insights into decision‐making practice. Collectively, both breakfast consumption and breakfast skipping can be considered viable habits, but they depend on individual preferences, planning, and the specific foods being consumed or omitted. When consumed, breakfast should consist primarily of functional foods typical for this meal (e.g., eggs, dairy products, nuts, fruits, whole grains, coffee, tea, etc.). While breakfast consumption aligns with chrononutrition principles, breakfast skipping can contribute to a calorie deficit over time, which has the potential for widespread cardiometabolic benefits for patients with overweight/obesity. The concepts and practical considerations discussed in the present review may aid health care personnel in personalising breakfast consumption recommendations for diverse patient populations.