bluuebunny/crossref_metadata_2025_split huggingface dataset:
AVPCD: a plant-derived medicine database of antiviral phytochemicals for cancer, Covid-19, malaria and HIV
Authors: Ullah Shahid , Rahman Wajeeha , Ullah Farhan , Ullah Anees , Ahmad Gulzar , Ijaz Muhammad , Ullah Hameed , Zheng Zilong , Gao Tianshun 
Published: August 2023

Abstract
Serious illnesses caused by viruses are becoming the world’s most critical public health issues and lead millions of deaths each year in the world. Thousands of studies confirmed that the plant-derived medicines could play positive therapeutic effects on the patients with viral diseases. Since thousands of antiviral phytochemicals have been identified as lifesaving drugs in medical research, a comprehensive database is highly desirable to integrate the medicinal plants with their different medicinal properties. Therefore, we provided a friendly antiviral phytochemical database AVPCD covering 2537 antiviral phytochemicals from 383 medicinal compounds and 319 different families with annotation of their scientific, family and common names, along with the parts used, disease information, active compounds, links of relevant articles for COVID-19, cancer, HIV and malaria. Furthermore, each compound in AVPCD was annotated with its 2D and 3D structure, molecular formula, molecular weight, isomeric SMILES, InChI, InChI Key and IUPAC name and 21 other properties. Each compound was annotated with more than 20 properties. Specifically, a scoring method was designed to measure the confidence of each phytochemical for the viral diseases. In addition, we constructed a user-friendly platform with several powerful modules for searching and browsing the details of all phytochemicals. We believe this database will facilitate global researchers, drug developers and health practitioners in obtaining useful information against viral diseases.
Transcriptomic Profiling and Cellular Composition of Creeping Fat in Crohn’s disease
Authors: Kim Kyuwon , Park Sojung , Lee Yoonho , Baek Jiwon , Kim Yongjae , Hwang Sung Wook , Lee Jong Lyul , Park Sang Hyoung , Yang Suk-Kyun , Han Buhm , Song Kyuyoung , Yoon Yong Sik , Lee Ho-Su , Ye Byong Duk 
Published: August 2023

Abstract

Background and Aims
Creeping fat [CF] is a poorly understood feature of Crohn’s disease [CD], characterized by the wrapping of mesenteric adipose tissue [MAT] around the inflamed intestine. The aim of this study was to investigate the transcriptional profile and compositional features of CF.

Methods
We collected 59 MAT samples: 23 paired samples from patients with CD (CF [CD-CF] and MAT around the uninflamed intestine [CD-MAT]) and 13 MAT samples from non-CD patients [Con-MAT]. Differentially expressed gene [DEG], functional pathway, cell deconvolution, and gene co-expression network analyses were performed.

Results
By comparing three different MAT samples, we identified a total of 529 DEGs [|log2FoldChange| &gt; 1.5; false discovery rate &lt; 0.05]. Of these, 323 genes showed an incremental pattern from Con-MAT to CD-MAT, and to CD-CF, while 105 genes displayed a decremental pattern. Genes with an incremental pattern were related to immune cell responses, including B- and T-cell activation, while genes with a decremental pattern were involved in cell trafficking and migration. Cell deconvolution analysis revealed significant changes in cellular composition between the CD-CF and Con-MAT groups, with increased proportions of B-cells/plasma cells [p = 1.16 × 10−4], T-cells [p = 3.66 × 10−3], and mononuclear phagocytes [p = 3.53 × 10−2] in the CD-CF group. In contrast, only the B-cell/plasma cell component showed a significant increase [p = 1.62 × 10−2] in the CD-MAT group compared to Con-MAT.

Conclusion
The distinct transcriptional profiles and altered cellular components of each MAT found in our study provide insight into the mechanisms behind CF and highlight its possible role in the pathogenesis of CD.
Adult Kawasaki disease: a rare and challenging diagnosis—a case report
Authors: O’ Connor Timothy , McNally Cora , Kennedy Mark W 
Published: August 2023

Abstract

Background
Kawasaki disease (KD) is an acute systemic vasculitis which predominantly occurs in childhood but rarely in adulthood. Diagnosis relies on the presence of typical clinical features; however, patients may present atypically, increasing the challenge of timely diagnosis for physicians.

Case summary
We report a case of a 40-year-old male presenting with persistent fever, rash, and unilateral neck swelling. Initial investigations were suggestive of necrotizing lymphadenitis, with a presumed infective aetiology. However, extensive microbiology and immunological investigations remained negative. Cardiac injury was evident with elevated troponin T and NT-proBNP; however, left ventricular systolic function was normal. After 4 days, clinical features consistent with KD were noted and the results of a lymph node biopsy supported this diagnosis. Despite timely treatment with intravenous immunoglobulins (IVIG) and high-dose aspirin, follow-up computed tomography (CT) coronary angiography demonstrated two sequential aneurysms (max 6 mm) in the right coronary artery, plus one small subtle aneurysm in the proximal left anterior descending artery (4 mm).

Discussion
Diagnosis of adult KD remains challenging, as symptoms often present sequentially over time rather than simultaneously and many of the clinical features necessary for diagnosis share commonality with other infectious disease processes.
Follow-up optical coherence tomography to evaluate circumflex ostium after fenestration of left main Papyrus covered stent: a case report
Authors: Maznyczka Annette , Arockiam Sacchin , Bulluck Heerajnarain , Mozid Abdul 
Published: August 2023

Abstract

Background
Left main (LM) perforations necessitating a covered stent risk sacrificing the side branch. The lost side branch can be promptly recovered by fenestration of the covered stent, using a stiff wire. However, it is unclear whether subsequent balloon angioplasty of the recovered side branch ostium is sufficient to preserve side branch patency. We report the longer-term patency of the circumflex (LCx) ostium after LM covered stenting.

Case summary
A 78-year-old lady, with stable angina, presented for elective angiography. Percutaneous coronary intervention of the left anterior descending (LAD) artery to LM was complicated by a distal LM perforation. A covered stent across the LM sealed the perforation but resulted in acute occlusion of the LCx. The LCx was rescued by fenestration of the covered stent with a stiff wire, followed by balloon angioplasty to the LCx ostium. At follow-up, the angina had resolved. However, follow-up angiography demonstrated a new severe stenosis at the LCx ostium, with remnants of the polyurethane membrane seen protruding into the LCx ostium on optical coherence tomography. Therefore, the LCx ostium was stented, using the reverse Culotte technique.

Conclusion
This case demonstrates that stenting the LCx ostium should be considered after covered stent implantation from LM to LAD, because balloon angioplasty of the LCx ostium may not provide a durable result in this scenario.
Simple bailout technique using a snare catheter for wire withdrawal during balloon-expandable transcatheter aortic valve implantation: a case report
Authors: Tsuda Masaki , Egami Yasuyuki , Kawanami Shodai , Nishino Masami 
Published: August 2023

Abstract

Background
In transcatheter aortic valve implantation (TAVI) using a SAPIEN3 balloon-expandable valve (S3), wire withdrawal from the left ventricle (LV) during the procedure before deployment can induce vascular injury in the access site or require surgical treatment when an S3 removal is attempted. We present a successful case of bailout from this situation safely with a minimally invasive technique using a 6-F snare catheter (SC).

Case summary
An 86-year-old woman with severe aortic stenosis underwent trans-femoral TAVI using an S3 under conscious sedation. After a pre-shaped wire was inserted into the LV from the right femoral artery, the LV wire was accidentally withdrawn completely from the LV before deployment. Wire re-insertion using a soft straight wire through the tip lumen of the S3 was hindered because the wire orientation was uncontrollable. Hence, we used a 6-F SC to control the wire direction by changing the orientation of the S3. Catching the tip of the S3 with an SC at the ascending aorta enabled us to control the wire direction, and wire re-insertion in the LV with the soft wire was successful. Furthermore, the SC worked well in advancing the S3 through the aortic valve to enhance co-axiality without aortic root injury. The S3 was successfully advanced through the aortic valve and implanted at an optimal position without complications.

Discussion
Our simple technique using a 6-F SC is technically effective, feasible, and minimally invasive and can be an option for bailout from accidental LV wire withdrawal during balloon-expandable valve TAVI.
End-stage heart failure in congenitally corrected transposition of the great arteries: a multicentre study
Authors: van Dissel Alexandra C , Opotowsky Alexander R , Burchill Luke J , Aboulhosn Jamil , Grewal Jasmine , Lubert Adam M , Antonova Petra , Shah Sangeeta , Cotts Timothy , John Anitha S , Kay William Aaron , DeZorzi Christopher , Magalski Anthony , Han Frank , Baker David , Kay Joseph , Yeung Elizabeth , Vonder Muhll Isabelle , Pylypchuk Stephen , Kuo Marissa C , Nicolarsen Jeremy , Sarubbi Berardo , Fusco Flavia , Jameson Susan M , Cramer Jonathan , Gupta Tripti , Gallego Pastora , O’Donnell Clare , Hannah Jane , Dellborg Mikael , Kauling Robert M , Ginde Salil , Krieger Eric V , Rodriguez Fred , Dehghani Payam , Kutty Shelby , Wong Joshua , Wilson William M , Rodriguez-Monserrate Carla P , Roos-Hesselink Jolien , Celermajer David S , Khairy Paul , Broberg Craig S 
Published: August 2023

Abstract

Background and Aims
For patients with congenitally corrected transposition of the great arteries (ccTGA), factors associated with progression to end-stage congestive heart failure (CHF) remain largely unclear.

Methods
This multicentre, retrospective cohort study included adults with ccTGA seen at a congenital heart disease centre. Clinical data from initial and most recent visits were obtained. The composite primary outcome was mechanical circulatory support, heart transplantation, or death.

Results
From 558 patients (48% female, age at first visit 36 ± 14.2 years, median follow-up 8.7 years), the event rate of the primary outcome was 15.4 per 1000 person-years (11 mechanical circulatory support implantations, 12 transplantations, and 52 deaths). Patients experiencing the primary outcome were older and more likely to have a history of atrial arrhythmia. The primary outcome was highest in those with both moderate/severe right ventricular (RV) dysfunction and tricuspid regurgitation (n = 110, 31 events) and uncommon in those with mild/less RV dysfunction and tricuspid regurgitation (n = 181, 13 events, P &lt; .001). Outcomes were not different based on anatomic complexity and history of tricuspid valve surgery or of subpulmonic obstruction. New CHF admission or ventricular arrhythmia was associated with the primary outcome. Individuals who underwent childhood surgery had more adverse outcomes than age- and sex-matched controls. Multivariable Cox regression analysis identified older age, prior CHF admission, and severe RV dysfunction as independent predictors for the primary outcome.

Conclusions
Patients with ccTGA have variable deterioration to end-stage heart failure or death over time, commonly between their fifth and sixth decades. Predictors include arrhythmic and CHF events and severe RV dysfunction but not anatomy or need for tricuspid valve surgery.
First isolation of a probiotic candidate Enterococcus mundtii from Herniaria glabra L. and evaluation of its wound healing activity
Authors: Fidan Aysenur , Ugras Serpil 
Published: August 2023

Abstract
In this study focused on probiotic properties of bacterium isolated from Herniaria glabra L. is a medicinal plant. The bacterium was isolated from H. glabra, and it was identified using the molecular method as Enterococcus mundtii AF-1 strain. Antibiotic sensitivity tests showed that AF-1 strain was sensitive to streptomycin, tobramycin, gentamicin, imipenem, erythromycin, and ciprofloxacin. The strain exhibited γ-haemolytic activity. These results show that the strain can be considered safe. The AF-1 strain showed inhibitory activity against some pathogens, including Bacillus subtilis, Klebsiella pneumoniae, and Yersinia pseudotuberculosis. Additionally, AF-1 strain exhibited high tolerance to low pH, pepsin, pancreatin, and bile salts. These properties showed that the strain may survival under the gastrointestinal conditions. The strain showed 40% DPPH free radical scavenging activity. The autoaggregation rate of the strain was 72.46% and the strain exhibited the high coaggregation rate (70.77% with Escherichia coli, and 63.78% with Listeria monocytogenesis). AF-1 strain showed 38.10% adhesion towards n-hexane, and 47.62% adhesion toward chloroform. It has been found to have moderate hydrophobicity. These results demonstrated the beneficial colonization ability of the strain in the gut. Furthermore, it was observed that living cells of AF-1 strain showed healing activity in the artificial wound area. Result of studies, it is seen that AF-1 strain might be excellent a probiotic candidate.
Electric shock causes a fleeing-like persistent behavioral response in the nematode Caenorhabditis elegans
Authors: Tee Ling Fei , Young Jared J , Maruyama Keisuke , Kimura Sota , Suzuki Ryoga , Endo Yuto , Kimura Koutarou D 
Published: August 2023

Abstract
Behavioral persistency reflects internal brain states, which are the foundations of multiple brain functions. However, experimental paradigms enabling genetic analyses of behavioral persistency and its associated brain functions have been limited. Here, we report novel persistent behavioral responses caused by electric stimuli in the nematode Caenorhabditis elegans. When the animals on bacterial food are stimulated by alternating current, their movement speed suddenly increases 2- to 3-fold, persisting for more than 1 minute even after a 5-second stimulation. Genetic analyses reveal that voltage-gated channels in the neurons are required for the response, possibly as the sensors, and neuropeptide signaling regulates the duration of the persistent response. Additional behavioral analyses implicate that the animal's response to electric shock is scalable and has a negative valence. These properties, along with persistence, have been recently regarded as essential features of emotion, suggesting that C. elegans response to electric shock may reflect a form of emotion, akin to fear.
Two disulfide-reducing pathways are required for the maturation of plastid c-type cytochromes in Chlamydomonas reinhardtii
Authors: Das Ankita , Subrahmanian Nitya , Gabilly Stéphane T , Andrianova Ekaterina P , Zhulin Igor B , Motohashi Ken , Hamel Patrice Paul 
Published: August 2023

Abstract
In plastids, conversion of light energy into ATP relies on cytochrome f, a key electron carrier with a heme covalently attached to a CXXCH motif. Covalent heme attachment requires reduction of the disulfide-bonded CXXCH by CCS5 and CCS4. CCS5 receives electrons from the oxidoreductase CCDA, while CCS4 is a protein of unknown function. In Chlamydomonas reinhardtii, loss of CCS4 or CCS5 yields a partial cytochrome f assembly defect. Here, we report that the ccs4ccs5 double mutant displays a synthetic photosynthetic defect characterized by a complete loss of holocytochrome f assembly. This defect is chemically corrected by reducing agents, confirming the placement of CCS4 and CCS5 in a reducing pathway. CCS4-like proteins occur in the green lineage, and we show that HCF153, a distant ortholog from Arabidopsis thaliana, can substitute for Chlamydomonas CCS4. Dominant suppressor mutations mapping to the CCS4 gene were identified in photosynthetic revertants of the ccs4ccs5 mutants. The suppressor mutations yield changes in the stroma-facing domain of CCS4 that restore holocytochrome f assembly above the residual levels detected in ccs5. Because the CCDA protein accumulation is decreased specifically in the ccs4 mutant, we hypothesize the suppressor mutations enhance the supply of reducing power through CCDA in the absence of CCS5. We discuss the operation of a CCS5-dependent and a CCS5-independent pathway controlling the redox status of the heme-binding cysteines of apocytochrome f.
The Relationship of Neighborhood Disadvantage, Biological Aging, and Psychosocial Risk and Resilience Factors in Heart Failure Incidence Among Black Persons: A Moderated Mediation Analysis
Authors: Bey Ganga S , Pike James R , Zannas Anthony S , Xiao Qian , Yu Bing , Shah Amil M , Palta Priya 
Published: August 2023

Abstract

Objectives
Deprived living environments contribute to greater heart failure (HF) risk among non-Hispanic Black persons, who disproportionately occupy disadvantaged neighborhoods. The mechanisms for these effects are not fully explicated, partially attributable to an insufficient understanding of the individual factors that contribute additional risk or resilience to the impact of neighborhood disadvantage on health. The objective of this study was, therefore, to clarify the complex pathways over which such exposures act to facilitate more targeted, effective interventions. Given the evidence for a mediating role of biological age and a moderating role of individual psychosocial characteristics in the neighborhood disadvantage–HF link, we tested a moderated mediation mechanism.

Methods
Using multilevel causal moderated mediation models, we prospectively examined whether the association of neighborhood disadvantage with incident HF mediated through accelerated biological aging, captured by the GrimAge epigenetic clock, is moderated by hypothesized psychosocial risk (negative affect) and resilience (optimism) factors.

Results
Among a sample of 1,448 Black participants in the shared Jackson Heart Study–Atherosclerosis Risk in Communities cohort (mean age 64.3 years), 334 adjudicated incident hospitalized HF events occurred over a median follow-up of 18 years. In models adjusted for age and sex, the indirect (GrimAge-mediated) effect of neighborhood disadvantage was moderated by psychosocial risk such that for every standard deviation increase in negative affect the hazards of HF was 1.18 (95% confidence interval = 1.05, 1.36). No moderated mediation effect was detected for optimism.

Discussion
Findings support the necessity for multilevel interventions simultaneously addressing neighborhood and individual psychosocial risk in the reduction of HF among Black persons.
Route 66: Mutations of the internal market explored through the prism of citation networks
Authors: Šadl Urška , López Zurita Lucía , Piccolo Sebastiano 
Published: August 2023

Abstract
The article rethinks the mutation of the internal market, charting its metamorphosis from a free trade area to a maze of common policies. It examines the case law of the European Court of Justice from a novel, structural perspective which uses community detection techniques to shed new light on this amply theorized process. The analysis reveals an irreversible shift in the method of integration, from a de-regulatory removal of national rules obstructing free movement (liberalization) to a re-regulatory adoption of common rules and standards promoting free movement (harmonization). The shift, which occurred between 2007 and 2010, signals a new rationale of integration and a reprioritization of the European Union’s economic and non-economic objectives. Finally, the article questions whether said shift calls for a new authorization of Europe to regulate.
Efficacy of catheter cleaning methods using intravenous indwelling catheter, 10% silver nitrate solution and a monofilament nylon thread for deeply progressed superficial driveline infections: case series
Authors: Kunioka Shingo , Watanabe Takuya , Mochizuki Hiroki , Nakaya Takako , Hori Yumiko , Miyoshi Eri , Konishi Nobuaki , Arizono Ayaka , Kitahata Nana , Hada Tasuku , Shimojima Masaya , Tsukamoto Yasumasa , Seguchi Osamu , Kamiya Hiroyuki , Tonai Kohei , Tadokoro Naoki , Kainuma Satoshi , Fukushima Satsuki , Fujita Tomoyuki , Fukushima Norihide 
Published: August 2023

Abstract
Driveline infection (DLI) is treated by local irrigation via driveline exit site (DLES) and surgical debridement is considered in patients with deep DLI. We describe three cases of deeply progressed superficial DLI that were considered to require surgical debridement but could be treated with a unique catheter cleaning method using intravenous indwelling catheter, a cotton swab with 10% silver nitrate solution and a monofilament nylon thread. Case 1 was a 60-y-old man with ischemic cardiomyopathy with left ventricular assist device implantation 2 y before. Daily bedside debridement with 10% silver nitrate solution was performed via the DLES. Case 2 was a 43-y-old man with ischemic cardiomyopathy who had recurrent DLI with methicillin-resistant Staphylococcus aureus, and case 3 was a 49-y-old woman with hypertrophic cardiomyopathy, who also showed improvement in their DLI with Pseudomonas aeruginosa. These cleaning methods may be useful for the deeply progressed superficial DLI.
Neonatal inguinal hernias containing the uterus: a case report on changes in uterine position
Authors: Muta Yuki , Odaka Akio , Inoue Seiichiro , Takeuchi Yuta , Beck Yoshifumi 
Published: August 2023

Abstract
A female newborn weighing 542 g and delivered at 27 weeks gestation presented with bilateral inguinal hernias while in the neonatal intensive care unit. Ultrasonography confirmed herniation of the uterus into the right inguinal hernia without signs of incarceration. Due to the absence of complications, she was discharged and scheduled for follow-up at the outpatient clinic. At 11 months of age, a subsequent ultrasonography showed only omental herniation, with no evidence of uterine prolapse. When she reached 1 year of age, a laparoscopic percutaneous extraperitoneal closure procedure was performed. During the surgery, it was observed that the uterus and fallopian tubes were located near the hernia orifice, but no clear prolapse was detected. The procedure concluded safely with successful high ligation. It has noted that in cases of uterine prolapse hernias, the uterus tends to recede as the child grows, which supports the decision to delay surgery for improved safety.
Calibrating SPI-ACS/INTEGRAL for gamma-ray bursts and re-estimating energetics of GRB/GW 190425 in gamma-ray range
Authors: Minaev P Yu , Pozanenko A S 
Published: August 2023

ABSTRACT
SPI-ACS/INTEGRAL is one of the most sensitive orbital gamma-ray detectors in energy range above 80 keV. Since 2002 it registered several thousands of gamma-ray bursts (GRBs), including the bursts associated with LIGO-Virgo gravitational wave events GW 170817 and GW 190425. No dedicated in-flight calibrations were performed for SPI-ACS/INTEGRAL, complicating estimation of spectral and energetic characteristics of an event. Using data of GBM/Fermi we perform cross-calibration of SPI-ACS/INTEGRAL, based on 1032 bright GRBs registered by both experiments. We find the conversion factor between instrumental counts from SPI-ACS and energy units from GBM to be dependent on hardness of GRB spectrum (defined as the characteristic energy value, Ep) and on location of a source in spacecraft-based coordinate system. We determine the corresponding analytical model to calculate the conversion factor and estimate its accuracy empirically. Sensitivity of SPI-ACS/INTEGRAL to detect gamma-ray transients is also investigated. Using the calibration we re-estimate energetics of GRB/GW 190425, detected by SPI-ACS/INTEGRAL alone. We constrain possible range of the characteristic energy Ep and isotropic equivalent of total energy, emitted in gamma-rays Eiso for GRB 190425, using the Ep, i–Eiso (Amati) correlation. The calibration model could be applied to any transients with energy spectrum, analogous to GRBs.