bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of acute high-intensity interval training and Tabata training on inhibitory control and cortical activation in young adults
Authors: Shao Xueyun , He Longfei , Liu Yangyang , Fu Yang 
Published: September 2023

IntroductionPhysical exercise not only benefits peoples’ health, but also improves their cognitive function. Although growing evidence suggests that high-intensity interval training (HIIT) is a time-efficient exercise regime that can improve inhibitory control performance by enhancing cortical activation in the prefrontal cortex, less is known about how Tabata training, a subset of HIIT that requires no equipment or facilities to perform, affects inhibitory control and cortical activation in young adults. Therefore, we aimed to reveal the effect of an acute bout of HIIT and Tabata training on inhibitory control and attempted to identify its potential neural substrates.MethodsForty-two young adults (mean age: 19.36 ± 1.36 years; 21 females) performed the Stroop task and Simon task before and after acute HIIT, Tabata training, or a control session, and cortical hemodynamic changes in the prefrontal area were monitored by functional near-infrared spectroscopy (fNIRS) during the tasks. Both HIIT and Tabata interventions lasted for a total of 12 min. The HIIT participants performed ergometer cycling at their 80% maximal aerobic power at 90–100 rpm, and the Tabata participants performed a total of 8 intense activities, such as jumping jacks, high knees, and butt kickers, without using equipment or facilities, keeping the heart rate at 80–95% of their maximum heart rate. Participants in the control group watched a sport video while sedentary. Cognitive tasks data and fNIRS data were analyzed by repeated-measures three-way ANOVA.Results and discussionOur results indicated that both the HIIT and Tabata groups exhibited reduced reaction times after the intervention, and there were alterations in activation patterns in the dorsolateral and ventrolateral prefrontal cortices.
Clinical predictors of NEDA-3 one year after diagnosis of pediatric multiple sclerosis: an exploratory single-center study
Authors: Palavra Filipe , Silva Diogo , Fernandes Catarina , Faustino Ricardo , Vasconcelos Mónica , Pereira Cristina , Costa Carmen , Ribeiro Joana Afonso , Amaral Joana , Robalo Conceição 
Published: September 2023

IntroductionMultiple sclerosis (MS) is an inflammatory and demyelinating disorder of central nervous system that can be diagnosed in pediatric age (&lt;18 years) in 3–5% of the cases. This early onset is associated with higher relapse rates and earlier progression to neurological disability. By using NEDA-3 (No Evidence of Disease Activity-3) criteria, we aimed to identify clinical predictors associated with absence of disease activity and control of disease progression 12 months after the diagnosis, in a cohort of pediatric-onset MS (POMS) patients regularly followed-up in our center.MethodsWe analyzed demographic, clinical, laboratorial and imaging variables of patients with POMS identified in our center, between 2010 and 2021, in two moments: at the diagnosis and 12 months after it. Statistical tests were applied to compare the distribution of those variables between groups defined by NEDA-3 status and by each one of its three variable components.ResultsWe included 27 patients in the study (18 female), with a mean age of 14.8 years (± 2.8), being all diagnosed with relapsing–remitting MS and with a median score of 1.5 at the Expanded Disability Status Scale (EDSS). The use of natalizumab (p = 0.017) and the negativity for anti-EBV IgG antibodies (p = 0.018) at diagnosis were associated with a higher achievement of NEDA-3 status 12 months after, in our cohort. Prescribed treatment was also associated with statistically significant differences in the “absence of MRI activity” component of NEDA-3 (p = 0.006): patients under treatment with natalizumab had a higher probability of achieving this status, and the opposite was observed in glatiramer acetate-treated children.Discussion and conclusionOur exploratory results underline the pivotal importance that an early and more effective therapeutical approach may have in the control of disease activity, in POMS. Additionally, they also seem to suggest that the presence of anti-EBV antibodies is not innocent, as it can be related to a less favorable evolution of the disease, even at a very early stage. Further studies are needed to confirm the applicability of these variables as prognostic and personalized tools in this clinical setting.
Role of micronutrients in the modulation of immune system and platelet activating factor in patients with COVID-19; a narrative review
Authors: Doaei Saeid , Mardi Afrouz , Zare Maryam 
Published: September 2023

BackgroundDietary micronutrients may play important roles in the improvement of the immune responses against SARS-CoV-2. This study aimed to assess the effect of micronutrients on platelet activating factor (PAF) and immunity with a special focus on the coronavirus disease 2019 (COVID-19).MethodsAll paper published in English on the effects of micronutrients including fat soluble vitamins, water soluble vitamins, and minerals on PAF, immunity, and COVID-19 were collected from online valid databases.ResultsVitamin A may modulate the expression of PAF-receptor gene in patients with COVID-19. Vitamin D may modulate inflammatory response through influencing PAF pathway. Vitamin E may improve COVID-19 related heart injuries by exert anti-PAF activities. Vitamin C status may have PAF related anti-inflammatory and micro-thrombotic effects in SARS-CoV-2 patients. Furthermore, some trace elements such as copper, selenium, and iron may have key roles in strengthens immunity by inactivate PAF acetyl hydrolase.ConclusionThis narrative review study highlighted the importance of micronutrients in the improvement of immune function through modulation of PAF in patients with COVID-19. Further longitudinal studies are warranted.
Evaluation of right ventricular longitudinal strain in pediatric patients with pulmonary hypertension by two-dimensional speckle-tracking echocardiography
Authors: Liu Qianjun , Hu Yuan , Chen Wenjuan , Yao Taoyue , Li Wenfeng , Xiao Zhenghui , Liu Jinqiao , Xiao Yunbin 
Published: September 2023

ObjectivesWe aimed to investigate the association between right ventricular longitudinal strain measured by two-dimensional speckle-tracking echocardiography (2D-STE) and right heart catheterization data in pediatric patients with pulmonary hypertension (PH).MethodsTwo groups were evaluated, each consisting of 58 patients. Group 1, patients with PH; Group 2, normal matched controls. Data were collected from 58 patients with PH who underwent invasive hemodynamic evaluation. Standard transthoracic echocardiographic assessment was performed in all patients under the same circumstances. All patients underwent 2D-STE, and off-line analysis generated right ventricle longitudinal strain (RVLS) and right ventricular free wall strain (RVFW) and collected echocardiographic conventional parameters of right ventricular function, including the control group. The relationship between invasive characteristics and right ventricular function parameters was analyzed.ResultsIn all, 58 PH patients were included in our study. The mean pulmonary artery pressure (mPAP) and pulmonary vascular resistance (PVR) were strongly correlated with right ventricular free wall strain (RVFW) and right ventricular longitudinal strain (RVLS), moderately correlated with the right ventricle myocardial performance index (Tei index), weakly correlated with the transverse diameter of the right ventricle (RV) and the transverse diameter of the right atrium (RA), and moderately negatively correlated with right ventricular fractional area change (RVFAC). In terms of segments of the right ventricular free wall, the basal segment had the highest correlation coefficient with mPAP and PVR (r = 0.413, 0.523, 0.578, r = 0.421, 0.533, 0.575, p &lt; 0.05, respectively). Tricuspid annular plane systolic excursion (TAPSE), main pulmonary artery diameter (MPA), peak systolic velocity of the right ventricle (RV-S’), and RA area parameters were not associated with mPAP and PVR (p &gt; 0.05).ConclusionsRight ventricular longitudinal strain is a reliable indicator to evaluate right ventricular function in pediatric patients with PH. It can provide valuable reference information for the clinical judgment of the status and severity of the disease in children.
Patient reported preferences for sleep interventions among women receiving buprenorphine for opioid use disorder
Authors: Eglovitch Michelle , Parlier-Ahmad Anna Beth , Legge Catherine , Chithranjan Sajanee , Kolli Saisriya , Violante Stephanie , Dzierzewski Joseph M. , Huhn Andrew Stephen , Wilkerson Allison , Martin Caitlin Eileen 
Published: September 2023

AimAmong individuals receiving medication for OUD (MOUD), insomnia is highly prevalent and increases the risk for negative OUD outcomes. However, little is known about MOUD patient-reported preferences for insomnia treatments among women with OUD. This mixed-methods study explored acceptability of and patient preferences for sleep interventions among women in OUD treatment.MethodsThis is an analysis from an ongoing cross-sectional survey and interview study investigating the relationship between sleep and OUD recovery. The parent study is actively enrolling non-pregnant women between 18–45 years stabilized on buprenorphine from an outpatient program. Participants complete measures including the Insomnia Severity Index (ISI), with scores of ≥10 identifying clinically significant insomnia symptoms. A sub-sample who met this threshold completed semi-structured interviews. Descriptive statistics were generated for survey responses, and applied thematic analysis was used for interview data.ResultsParticipants selected for the qualitative interview (n = 11) highlighted prior positive and negative experiences with sleep treatments, challenges with employing non-pharmacological sleep strategies, and preferences for both medical and behavioral sleep interventions while in recovery. Women emphasized the need for flexibility of sleep therapy sessions to align with ongoing social determinants (e.g., caregiving responsibilities) as well as for sleep medications without sedating effects nor risk of dependency.ConclusionsMany women receiving MOUD have concomitant insomnia symptoms, and desire availability of both pharmacologic and behavioral sleep interventions within the OUD treatment setting. Qualitative findings underscore the need for evidence-based sleep interventions that account for the unique socioenvironmental factors that may impact strategy implementation in this population.
Influence of job satisfaction on SRH and happiness among Korean disabled workers: findings from the panel survey of employment for the disabled 2016–2018
Authors: Lee Young Lim , Yang Jeong Min , Kim Jae-Hyun 
Published: September 2023

BackgroundAn understanding of the economic life activities of persons with disabilities (PWD) is important. Their ability to perform tasks and an increase in their income are more likely to yield an improvement in their Self-Rated Health (SRH) and happiness. However, there is still a lack of understanding of the specific associations among PWD in South Korea. Thus, this study conducted a longitudinal analysis of the association between job satisfaction and SRH, happiness among the Korean PWD.MethodsAfter excluding missing values, data on 1,637 participants at baseline (1st wave) were analyzed using the chi-square test, t-test, Analysis of Variance (ANOVA) and generalized estimating equation (GEE) model for data from 1st to 3rd Panel Survey of Employment for the Disabled (PSED). All analyses were conducted using the SAS statistical software package, version 9.4.ResultsCompared to very high job satisfaction group, low job satisfaction group was more likely to experience negative SRH [odds ratio (OR): 3.497, value of p: &lt;0.0001] and experience low happiness (B: −0.291, value of p: &lt;0.0001). Furthermore, in terms of the overall satisfaction with current job among the PWD, compared to the ‘very satisfied’ group, ‘very unsatisfied’ group had higher negative SRH (OR: 5.158, value of p: 0.003) and lower happiness (B: −0.327, value of p: &lt;0.0001).ConclusionThis study suggests that increasing job satisfaction of PWD possibly leads to decreased negative SRH and to increased happiness, resulting in better SRH and happiness. Furthermore, it suggests the establishment of systemic, policy-oriented measures to enhance the employment opportunities for disabled individuals in Korea and create an inclusive working environment that aligns with their respective job responsibilities.
Using participatory action research to empower district hospital staff to deliver quality-assured essential surgery to rural populations in Malawi, Zambia, and Tanzania
Authors: Pittalis Chiara , Drury Grace , Mwapasa Gerald , Borgstein Eric , Cheelo Mweene , Kachimba John , Juma Adinan , Chilonga Kondo , Cahill Niamh , Brugha Ruairi , Lavy Chris , Gajewski Jakub 
Published: September 2023

BackgroundIn 2017 the SURG-Africa project set out to institute a surgical, obstetric, trauma and anesthesia (SOTA) care capacity-building intervention focused on non-specialist providers at district hospitals in Zambia, Malawi and Tanzania. The aim was to scale up quality-assured SOTA care for rural populations. This paper reports the process of developing the intervention and our experience of initial implementation, using a participatory approach.MethodsParticipatory Action Research workshops were held in the 3 countries in July–October 2017 and in October 2018–July 2019, involving representatives of key local stakeholder groups: district hospital (DH) surgical teams and administrators, referral hospital SOTA specialists, professional associations and local authorities. Through semi-structured discussions, qualitative data were collected on participants’ perceptions and experiences of barriers to the provision of SOTA care at district level, and on the training and supervision needs of district surgical teams. Data were compared for themes across countries and across surgical team cadres.ResultsAll groups reported a lack of in-service training to develop essential skills to manage common SOTA cases; use and care of equipment; essential anesthesia care including resuscitation skills; and infection prevention and control. Very few district surgical teams had access to supervision. SOTA providers at DHs reported a demand for more feedback on referrals. Participants prioritized training needs that could be addressed through regular in-service training and supervision visits from referral hospital specialists to DHs. These data were used by participants in an action-planning cycle to develop site-specific training plans for each research site.ConclusionThe inclusive, participatory approach to stakeholder involvement in SOTA system strengthening employed by this study supported the design of a locally relevant and contextualized intervention. This study provides lessons on how to rebalance power dynamics in Global Surgery, through giving a voice to district surgical teams.
Proposals of guidance values for surface contamination by antineoplastic drugs based on long term monitoring in Czech and Slovak hospitals and pharmacies
Authors: Bláhová Lucie , Bláha Luěek , Doležalová Lenka , Kuta Jan , Hojdarová Tereza 
Published: September 2023

IntroductionThe exposures to hazardous antineoplastic drugs (AD) represent serious risks for health care personnel but the exposure limits are not commonly established because of the no-threshold effects (genotoxic action, carcinogenicity) of many ADs. In this study, we discussed and derived practically applicable technical guidance values (TGV) suitable for management of AD risks.MethodsThe long-term monitoring of surface contamination by eight ADs was performed in pharmacies and hospitals in the Czech Republic and Slovak Republic in 2008–2021; in total 2,223 unique samples were collected repeatedly in 48 facilities. AD contamination was studied by LC-MS/MS for cyclophosphamide, ifosfamide, methotrexate, irinotecan, paclitaxel, 5-fluorouracil and gemcitabine and by ICP-MS for total Pt as a marker of platinum-based ADs.ResultsThe study highlighted importance of exposure biomarkers like 5-fluorouracil and especially carcinogenic and persistent cyclophosphamide, which should be by default included in monitoring along with other ADs. Highly contaminated spots like interiors of laminar biological safety cabinets represent a specific issue, where monitoring of contamination does not bring much added value, and prevention of staff and separated cleaning procedures should be priority. Rooms and surfaces in health care facilities that should be virtually free of ADs (e.g., offices, kitchenettes, daily rooms) were contaminated with lower frequency and concentrations but any contamination in these areas should be carefully examined.Discussion and conclusionsFor all other working places, i.e., majority of areas in pharmacies and hospitals, where ADs are being prepared, packaged, stored, transported, or administered to patients, the study proposes a generic TGV of 100 pg/cm2. The analysis of long-term monitoring data of multiple ADs showed that the exceedance of one TGV can serve as an indicator and trigger for improvement of working practices contributing thus to minimizing of unintended exposures and creating a safe work environment.
Bibliometric study on artistic swimming
Authors: Rincón Ane Begoñe , Trinidad Alfonso , López-Valenciano Alejandro 
Published: September 2023

IntroductionThe objective of this paper is to study the research trends in the sport modality of artistic swimming and to analyse the scientific production regarding this sport.MethodsTwo hundred and twenty articles related to the theme were selected after a search in the PubMed, SPORTDiscus and Web of Science databases and some additional records, using the theme “synchronised swimming OR artistic swimming” up to December 2022. The variables scrutinized were the following: (1) title, (2) discipline, (3) type, (4) sample size and (5) sporting level.ResultsThe results indicate that (1) 53.6% of the artistic swimming articles were case studies, (2) 23.2% talked about physiology, (3) 32.7% had a sample of 11–50 participants, and (4) 30.9% of the sample was elite/international swimmers.DiscussionOver the years there has been a considerable increase in studies on artistic swimming; the topics of greatest interest in artistic swimming have been physiology, sports performance and injuries. Even so, it seems that for the moment artistic swimming has little impact, probably due to its status as a minority sport and it having limited social and economic impact.
Human Alcohol-Microbiota Mice have Increased Susceptibility to Bacterial Pneumonia
Authors: Cunningham Kelly C. , Smith Deandra R. , Villageliú Daniel N. , Ellis Christi M. , Ramer-Tait Amanda E. , Price Jeffrey D. , Wyatt Todd A. , Knoell Daren L. , Samuelson Mystera M. , Molina Patricia E. , Welsh David A. , Samuelson Derrick R. 
Published: September 2023

Preclinical studies have shown that chronic alcohol abuse leads to alterations in the gastrointestinal microbiota that are associated with behavior changes, physiological alterations, and immunological effects. However, such studies have been limited in their ability to evaluate the direct effects of alcohol-associated dysbiosis. To address this, we developed a humanized alcohol-microbiota mouse model to systematically evaluate the immunological effects of chronic alcohol abuse mediated by intestinal dysbiosis. Germ-free mice were colonized with human fecal microbiota from individuals with high and low Alcohol Use Disorders Identification Test (AUDIT) scores and bred to produce human alcohol-associated microbiota or human control-microbiota F1 progenies. F1 offspring colonized with fecal microbiota from individuals with high AUDIT scores had increased susceptibility to Klebsiella pneumoniae and Streptococcus pneumoniae pneumonia, as determined by increased mortality rates, pulmonary bacterial burden, and post-infection lung damage. These findings highlight the importance of considering both the direct effects of alcohol and alcohol-induced dysbiosis when investigating the mechanisms behind alcohol-related disorders and treatment strategies.
The Effects of Dipeptidyl Peptidase-4 Inhibitors on Kidney Function in Advanced CKD
Authors: İSLAM Mahmud , GENÇ Ahmed Cihad 
Published: September 2023

Objective: This study aimed to investigate the effects of DPP-4 inhibitors on kidney function in type 2 diabetes mellitus patients with stages 3-5 chronic kidney disease, focusing on estimated glomerular filtration rate and proteinuria.
Methods: This is a retrospective case-control design, and data were collected from a single hospital's software and the Turkish Ministry of Health's National Data Tracking System. Diabetic patients with T2DM and CKD stages 3-5 were included, with dipeptidyl peptidase-4 inhibitor users (n=118) and non-users (n=48) forming the intervention and control groups, respectively. Baseline demographics, clinical characteristics, and outcomes were compared between groups.
Results: At baseline, both groups demonstrated similar age, gender distribution, body mass index, and eGFR. Over a 12-month follow-up, while slight improvements in eGFR were observed in the intervention group and minor reductions in the control group, these changes did not reach statistical significance (p>0.05). Proteinuria showed a stable trend in the intervention group, whereas a significant increase was noted in the control group (p=0.035). Age significantly correlated with eGFR (p
PENGARUH RASIO L/D ANTARA LAPISAN MORTAR GEOPOLIMER BERBAHAN DASAR FLY ASH TERHADAP KUAT TEKAN BETON DENGAN SEAWATER CURING
Authors: Nastiti Syahidah Fani 
Published: September 2023

ABSTRAK
The performance and durability of concrete in construction is essential to maintain the sustainability and protection of the material. Particularly in construction in marine environments, the attack of aggressive chemical compounds can affect concrete and accelerate deterioration. This research aims to improve the performance and durability of concrete in construction in marine environments by using additional protection methods such as Surface Applied Protection. One of the materials used is geopolymer mortar that uses fly ash as a base material. This study shows that geopolymer mortar contributes positively to the compressive strength and durability of concrete. The thickness of the geopolymer mortar layer affected the mechanical properties of the concrete, and 4 cm thick gave the highest compressive strength results. The addition of geopolymer mortar needs to be adjusted to the compressive strength of the concrete and pay attention to the layer thickness for optimal results.

Kata kunci: repair material, marine environment, L/D ratio, geopolymer mortar, compressive strength