bluuebunny/crossref_metadata_2025_split huggingface dataset:
The role of effortful control in mitigating negative consequences associated with emerging adult drinking
Authors: Paige Katie J. , Shaw Rachael J. , Colder Craig R. 
Published: February 2023

AbstractBackgroundIdentifying factors that protect against alcohol‐related negative consequences associated with emerging adult drinking is a critical public health issue. It has been proposed that high levels of self‐regulation moderate risks associated with drinking, decreasing alcohol‐related negative consequences. Past research testing this possibility is limited by a lack of advanced methodology for testing moderation and failure to consider facets of self‐regulation. This study addressed these limitations.MethodsThree hundred fifty‐four community emerging adults (56% female; predominantly non‐Hispanic Caucasian (83%) or African American (9%)) were assessed annually for 3 years. Moderational hypotheses were tested using multilevel models and the Johnson‐Neyman technique was used to examine simple slopes. Data were organized such that repeated measures (level 1) were nested within participants (level 2) to test cross‐sectional associations. Self‐regulation was operationalized as effortful control and its facets (attentional, inhibitory, and activation control).ResultsWe found evidence of moderation. The association between alcohol use during a heavy drinking week and consequences weakened as effortful control increased. This pattern was supported for two facets (attentional and activation control), but not for inhibitory control. Regions of significance results revealed that this protective effect was only evident at very high levels of self‐regulation.ConclusionsThe results provide some evidence that very high levels of attentional and activation control protect against alcohol‐related negative consequences associated with drinking. Emerging adults who are very high in attentional and activation control are likely better able to control their attention and engage in goal‐directed behavior, like leaving a party at a reasonable hour, or attending school and/or work when experiencing the punishing effects of a hangover. Results emphasize the importance of distinguishing facets of self‐regulation when testing self‐regulation models.
From natural language to accounting entries using a natural language processing method
Authors: Chen Yasheng , Huang Xian , Wu Zhuojun 
Published: February 2023

AbstractBookkeeping is crucial in both accounting and auditing. However, a substantial quantity of accounting information initially recorded using unstructured natural language, which restricts the efficiency and accuracy of bookkeeping. In this study, we exploit proprietary transaction data from three firms to demonstrate the capacity of a word embedding approach based on a neural network model (i.e., Word2vec) for processing transaction‐related natural language and automating bookkeeping practice. Our study contributes to accounting practice and literature by demonstrating a practical application of Word2vec to the construction of an automated bookkeeping system.
Advertising and general dental practice: how compliant are practice websites in Australia with legal requirements?
Authors: Jensen ED , Sethi S , Poirier BF , Meade MJ 
Published: February 2023

ABSTRACTBackgroundThe Australian Health Practitioner Regulation Agency (AHPRA) requires general dental practitioners (GDPs) to agree to regulatory advertising guidelines on initial registration and annual renewal. The aim of this study was to determine the compliance of GDPs websites to these requirements.MethodsA representative sample of GDPs websites from each state and territory in Australia was based on the total AHPRA registrant distribution. Assessment of compliance was used across five domains consisting of 17 criteria related to AHPRA's advertising of regulated health services guidelines, as well as section 133 of the National Law. Inter‐rater reliability was estimated using Fleiss's Kappa.ResultsOne hundred and ninety‐two GDPs websites were reviewed with 85% non‐compliant with at least one of the legal and regulatory requirements relating to advertising. Of these websites, 52% displayed false and misleading information, 12.8% had offers and inducement without clear terms and conditions, 11.5% used written testimonials, 33.9% created unrealistic expectation of benefit and 39.6% encouraged indiscriminate and unnecessary use of health services.ConclusionsMore than 85% of GDP websites in Australia did not comply with legal and regulatory requirements related to advertising. A multi‐stakeholder approach involving AHPRA, professional dental bodies and dental registrants is necessary to improve compliance.
Efficacy of different irrigation agitation systems in the removal of root canal sealers from artificial standardised grooves
Authors: Düzgün Salih , Topçuoğlu Hüseyin Sinan , Kahraman Ömür , Eminsoy Ayşe Tuğba 
Published: February 2023

AbstractThe present study aims to assess the efficacy of different irrigation agitation systems in removing calcium silicate‐based sealers from artificial standardised apical grooves. After the root canal instrumentation of 96 teeth, artificial apical grooves were created in half of each root. The samples were divided into two main groups according to the sealer type (AH Plus Jet [APJ] and Sure‐Seal Root™ [SSR]) (n = 48). The root halves were then reassembled and divided into four experimental groups based on the final irrigation technique used: Conventional Syringe Irrigation (CSI), Ultrasonic Irrigant Agitation (UIA), Sonic Agitation (SA) and Manual Dynamic Agitation (MDA). The roots were then dissembled to assess the amount of root canal sealer. UIA significantly removed more of SSR sealer than CSI, MDA and SA while there was no statistical difference between CSI, MDA, SA and UIA groups in the APJ group. None of the irrigation agitation systems used had completely removed the APJ and SSR sealers. However, UIA was more effective in removing SSR sealer from the standardised apical groove than were CSI, MDA and SA.
Gene‐edited or genetically modified food? The impacts of risk and ambiguity on Chinese consumers' willingness to pay
Authors: Ding Yulian , Yu Jianyu , Sun Yangyang , Nayga Rodolfo M. , Liu Yunyun 
Published: February 2023

AbstractThis study investigates consumer preferences for newly introduced gene‐edited (GE) food. We focus on how risk and ambiguity aversion affect consumers’ willingness to pay (WTP) to avoid genetically modified (GM) food or GE food and whether the impacts of risk and ambiguity aversion differ between GM and GE food. We collected the data in 2020 through a nationwide online survey in China. The multiple price list method is used to estimate the premiums that consumers are willing to pay for conventional rice to avoid GM/GE rice. Our results show that Chinese urban consumers are more concerned about the health, environmental, and ethical impacts of genetic modification than gene editing technology. They are willing to pay lower premiums when the alternative is GE rice than when it is GM rice. We further find that both risk aversion and ambiguity aversion have significant negative impacts on respondents’ WTP for food derived from gene technologies, with ambiguity aversion being more influential than risk aversion for both GM and GE rice. However, there is no significant difference in how risk aversion and ambiguity aversion affect the respondents’ WTP to avoid GM or GE rice.
The effects of the invasive species, Lantana camara, on regeneration of an African rainforest
Authors: Barahukwa Anke , Chapman Colin A. , Namaganda Mary , Eilu Gerald , Omeja Patrick A. , Lawes Michael J. 
Published: February 2023

AbstractInvasive plants adversely affect native communities by altering ecosystem function and disrupting natural regeneration. We investigate the effect of invasive Lantana camara L. (Verbenaceae) on forest regeneration in Kibale National Park, Uganda. We appraise the efficacy of cutting and uprooting Lantana for promoting native tree recruitment. Sample plots comprised three types: (i) currently invaded by Lantana; (ii) cleared of Lantana and now managed; and (iii) forest reference plots uninvaded by Lantana. Tree species numbering 51, 19 shrubs, and 17 herb species were identified. Lantana reduced tree, shrub, and herb cover and diversity, and suppressed tree regeneration. The short‐term management of Lantana did not promote tree establishment. The tree community in cleared areas was not converging on uninvaded adjacent forest. Lantana is known to allelopathically suppress tree seedling establishment, but even at sites cleared of Lantana, tree species recruitment was poor. While insufficient time may have passed for tree recruitment, we argue that an increase in shrub and herb cover and diversity arrested forest tree regeneration. Sustained follow‐up clearing of dense secondary shrubs and herbs and resprouted L. camara in cleared areas is key to ensuring long‐term recovery of the forest tree community.
Bacterial resistance to commonly prescribed antibiotics was rare among children hospitalised for clinical dysentery
Authors: Goldshtein Regina , Sharon Nechama , Yana Moshe , Rubinstein Uri , Amir Achiya Z. 
Published: February 2023

AbstractAimTemporal changes in common pathogens that cause clinical dysentery have been described in Europe. We aimed to describe the distribution of pathogens and their antibiotic resistance in hospitalised Israeli children.MethodsThis study retrospectively studied children hospitalised for clinical dysentery, with or without a positive stool culture, from 1 January 2016 to 31 December 2019.ResultsWe diagnosed 137 patients (65% males), with clinical dysentery at a median age of 3.7 (interquartile range 1.5–8.2) years. Stools were cultured in 135 patients (99%), and the results were positive in 101 (76%). These comprised Campylobacter (44%), Shigella sonnei (27%), non‐typhoid Salmonella (18%) and enteropathogenic Escherichia coli (12%). Only one of the 44 Campylobacter cultures was resistant to erythromycin and one of the 12 enteropathogenic Escherichia coli cultures was resistant to ceftriaxone. None of the Salmonella and Shigella cultures were resistant to ceftriaxone or erythromycin. We did not find any pathogens that were associated with a typical clinical presentation or laboratory results on admission.ConclusionThe most common pathogen was Campylobacter, in line with recent European trends. Bacterial resistance for commonly prescribed antibiotics was rare, and these findings support the current European recommendations.
Evaluation of the effect of ritlecitinib on the pharmacokinetics of caffeine in healthy participants
Authors: Liu Jian , Solan Rohit , Wolk Robert , Plotka Anna , O'Gorman Melissa T. , Winton Jennifer A. , Kaplan Julia , Purohit Vivek S. 
Published: February 2023

AimsThis clinical study was conducted to evaluate the impact of ritlecitinib on the pharmacokinetics of caffeine, a cytochrome P450 1A2 (CYP1A2) substrate.MethodsIn this single‐centre, single‐arm, open‐label, fixed‐sequence study, healthy participants received a single 100‐mg dose of caffeine on 2 separate occasions: on Day 1 of Period 1 as monotherapy and on Day 8 of Period 2 after oral administration of ritlecitinib 200 mg once daily for 8 days. Serial blood samples were collected and analysed using a validated liquid chromatography–mass spectrometry assay. Pharmacokinetic parameters were estimated by using a noncompartmental method. Safety was monitored by physical examination, vital signs, electrocardiograms and laboratory assessments.ResultsTwelve participants were enrolled and completed the study. Coadministration of caffeine 100 mg in the presence of steady‐state levels of ritlecitinib (200 mg once daily) increased caffeine exposure compared with caffeine given alone. Area under the curve to infinity and maximum concentration of caffeine increased by approximately 165 and 10%, respectively, when coadministered with ritlecitinib. The ratios of the adjusted geometric means (90% confidence interval) for caffeine area under the curve to infinity and maximum concentration were 265.14% (234.12–300.26%) and 109.74% (103.90–15.91%), respectively, when caffeine was coadministered with steady‐state ritlecitinib (test) compared with its administration alone (reference). Multiple doses of ritlecitinib when coadministered with a single dose of caffeine were generally safe and well tolerated in healthy participants.ConclusionRitlecitinib is a moderate inhibitor of CYP1A2 and can increase systemic exposures of CYP1A2 substrates.
Individualized Causal Discovery with Latent Trajectory Embedded Bayesian Networks
Authors: Zhou Fangting , He Kejun , Ni Yang 
Published: February 2023

AbstractBayesian networks have been widely used to generate causal hypotheses from multivariate data. Despite their popularity, the vast majority of existing causal discovery approaches make the strong assumption of a (partially) homogeneous sampling scheme. However, such assumption can be seriously violated, causing significant biases when the underlying population is inherently heterogeneous. To this end, we propose a novel causal Bayesian network model, termed BN-LTE, that embeds heterogeneous samples onto a low-dimensional manifold and builds Bayesian networks conditional on the embedding. This new framework allows for more precise network inference by improving the estimation resolution from the population level to the observation level. Moreover, while causal Bayesian networks are in general not identifiable with purely observational, cross-sectional data due to Markov equivalence, with the blessing of causal effect heterogeneity, we prove that the proposed BN-LTE is uniquely identifiable under relatively mild assumptions. Through extensive experiments, we demonstrate the superior performance of BN-LTE in causal structure learning as well as inferring observation-specific gene regulatory networks from observational data.
Greater expectations or less sugar‐coating? Perceptual underpinnings of constructive patriotism
Authors: Sekerdej Maciej , Rupar Mirjana , Jamróz‐Dolińska Katarzyna , Kołeczek Maryna 
Published: February 2023

AbstractIn order to clarify the perceptual underpinnings of critical national attachment, we examined the links between constructive (critical) and conventional patriotism, and evaluations of the actual and ideal representations of the country. Across four studies conducted on US and Polish samples (total N = 3457), perception of a discrepancy between the actual and the ideal representations of the country was positively linked to constructive but negatively to conventional patriotism. Moreover, constructive patriotism was linked positively and conventional patriotism negatively with being critical of the actual functioning of the country. However, both constructive and conventional patriotisms were positively linked with the height of expectations of how the country should function. Additionally, we showed that discrepancy may motivate constructive patriots to be civically engaged (Study 4). Overall, the findings suggest that the difference between constructive and conventional patriots lies principally in how they evaluate the actual state of the country rather than in the degree to which they set high expectations or standards for the country.
Decellularised spinal cord matrix manipulates glial niche into repairing phase via serglycin‐mediated signalling pathway
Authors: Zhang Sheng , Zhai Man , Xu Yiwei , Han Jiandong , Chen Jiaxin , Xiong Yucui , Pan Shihua , Wang Qizheng , Yu Chunlai , Rao Zilong , Sun Qi , Sui Yufei , Fan Ke , Li Heying , Guo Wenjing , Liu Cuicui , Bai Ying , Zhou Jing , Quan Daping , Zhang Xiao 
Published: February 2023

AbstractAstrocytes are the most abundant and widespread glial cells in the central nervous system. The heterogeneity of astrocytes plays an essential role in spinal cord injury (SCI) repair. Decellularised spinal cord matrix (DSCM) is advantageous for repairing SCI, but little is known regarding the exact mechanisms and niche alterations. Here, we investigated the DSCM regulatory mechanism of glial niche in the neuro‐glial‐vascular unit using single‐cell RNA sequencing. Our single cell sequencing, molecular and biochemical experiments validated that DSCM facilitated the differentiation of neural progenitor cells through increasing the number of immature astrocytes. Upregulation of mesenchyme‐related genes, which maintained astrocyte immaturity, causing insensitivity to inflammatory stimuli. Subsequently, we identified serglycin (SRGN) as a functional component of DSCM, which involves inducing CD44–AKT signalling to trigger human spinal cord‐derived primary astrocytes (hspASCs) proliferation and upregulation of genes related to epithelial–mesenchymal transition, thus impeding astrocyte maturation. Finally, we verified that SRGN‐COLI and DSCM had similar functions in the human primary cell co‐culture system to mimic the glia niche. In conclusion, our work revealed that DSCM reverted astrocyte maturation and altered the glia niche into the repairing phase through the SRGN‐mediated signalling pathway.
Letting Tourette's be: The importance of understanding lived experience in research and the clinic
Authors: Bervoets Jo , Beljaars Diana , De Jaegher Hanne 
Published: February 2023

AbstractThe most common clinical research question regarding Tourette syndrome focuses on tic reduction, which follows from classical ‘lack of inhibition’ models. Rooted in views about brain deficits, this model suggests that with higher severity and frequency, tics are necessarily disruptive and should therefore be inhibited. However, emerging calls from people with lived experience of Tourette syndrome suggest that this is too narrow a definition. This narrative literature review analyses issues with brain deficit views and qualitative research on tic context and feelings of compulsion. The results suggest the need for a more positive and encompassing theoretical and ethical position on Tourette's. The article puts forward an enactive analytical approach of ‘letting be’, that is, approaching a phenomenon without forcing preconceived reference structures onto it. We suggest using the identity‐first term ‘Tourettic’. Prioritizing the perspective of the ‘Tourettic patient’, it urges attentiveness to the everyday issues diagnosed people encounter and how these are embedded in further life. This approach highlights the strong relationship between the Tourettic persons' felt impairment, their adoption of an outsider's perspective, and feeling under constant scrutiny. It suggests that this felt impairment of tics can be reduced by creating a physical and social environment in which the person is ‘let be’ but not ‘let go of’.What this paper adds

Its theoretical position allows a more holistic view of Tourette's, integrating tics with oft‐overlooked complex compulsions.
The ‘letting be’ position also allows us to view why the presentation of Tourette's is likely to vary with gender and age of onset.
‘Letting be’ is a promising approach to improve a clinical understanding of Tourettic well‐being over and above tic severity and frequency.
It integrates quantitative research on Tourette syndrome in the neurosciences with qualitative neurodiversity literature in the medical humanities.
It integrates ethical frameworks as developed in enactive philosophy with the conceptualization and treatment of tics and compulsions.
Effectiveness of educational and behavioural interventions for reducing fear of hypoglycaemia among adults with type 1 diabetes: Systematic review and meta‐analyses
Authors: Chatwin Hannah , Broadley Melanie , de Galan Bastiaan , Bazelmans Ellen , Speight Jane , Pouwer Frans , Nefs Giesje 
Published: February 2023

AbstractAimsTo summarize and critically appraise evidence regarding the effectiveness of educational and/or behavioural interventions in reducing fear of hypoglycaemia among adults with type 1 diabetes.MethodsSystematic searches of medical and psychology databases were conducted. Risk‐of‐bias was assessed using the Joanna Briggs Institute Critical Appraisal Tools. Data were synthesized using random‐effects meta‐analyses for randomized controlled trials (RCTs) and narrative synthesis for observational studies.ResultsFive RCTs (N = 682) and seven observational studies (N = 1519) met the inclusion criteria, reporting on behavioural, structured education and cognitive‐behavioural therapy (CBT) interventions. Most studies assessed fear of hypoglycaemia using the Hypoglycaemia Fear Survey Worry (HFS‐W) and Behaviour (HFS‐B) subscales. Mean fear of hypoglycaemia at baseline was relatively low across studies. Meta‐analyses showed a significant effect of interventions on HFS‐W (SMD = −0.17, p = 0.032) but not on HFS‐B scores (SMD = −0.34, p = 0.113). Across RCTs, Blood Glucose Awareness Training (BGAT) had the largest effect on HFS‐W and HFS‐B scores, and one CBT‐based program was as effective as BGAT in reducing HFS‐B scores. Observational studies showed that Dose Adjustment for Normal Eating (DAFNE) was associated with significant fear of hypoglycaemia reductions.ConclusionsCurrent evidence suggests that educational and behavioural interventions can reduce fear of hypoglycaemia. However, no study to date has examined these interventions among people with high fear of hypoglycaemia.
Insight into the causality between basal metabolic rate and endometrial and ovarian cancers: Analysis utilizing systematic Mendelian randomization and genetic association data from over 331,000 UK biobank participants
Authors: Zhang Haifeng , Qiu Junlan , Meng Fang , Shu Xiaochen 
Published: February 2023

AbstractBackgroundObservational studies have demonstrated that basal metabolic rate (BMR) is associated with the risk of endometrial cancer (EC) and ovarian cancer (OC). However, it is unclear whether these associations reflect a causal relationship.ObjectiveTo reveal the causality between BMR and EC and OC, we performed the first comprehensive two‐sample Mendelian randomization (MR) analyses.MethodsGenetic variants were used as proxies of BMR. GWAS summary statistics of BMR, EC and OC were obtained from the UK Biobank Consortium, Endometrial Cancer Association Consortium and Ovarian Cancer Association Consortium respectively. The inverse variance weighted method was employed as the main approach for MR analysis. A series of sensitivity analyses were implemented to validate the robustness and reliability of the results.ResultsBMR was significantly related to an increased risk of EC (ORSD = 1.49; 95% CI: 1.29–1.72; p‐Value < .001) and OC (ORSD = 1.21; 95% CI: 1.08–1.35; p‐Value < .001). Furthermore, the stratified analysis indicated that BMR was positively associated with endometrioid endometrial cancer (EEC) (ORSD = 1.45; 95% CI, 1.23–1.70; p‐Value < .001), clear cell ovarian cancer(CCOC) (ORSD = 1.89; 95% CI:1.35–2.64; p‐Value < .001) and endometrioid ovarian cancer risk (EOC) (ORSD = 1.45; 95% CI: 1.12–1.88; p‐Value = .005). However, there were no significant associations of BMR with invasive mucinous ovarian cancer (IMOC), high‐grade serous ovarian cancer (HGSOC) and low‐grade serous ovarian cancer (LGSOC). The robustness of the above results was further verified in sensitivity analyses.ConclusionThe MR study provided etiological evidence for the positive association of BMR with the risk of EC, EEC, OC, CCOC and EOC. But this study did not provide enough evidence suggesting the causal associations of BMR with IMOC, HGSOC and LGSOC.