bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Panoramic View of Morphological Spectrum of Male Breast Lesions at a Tertiary Care Hospital in South India
Authors: Mittal Salony , Shefali Goyal , Saumya Mittal , Hema Kini , Deepa Adiga 
Published: January 2023

Abstract
Background:
Though male breast lesions are infrequently studied and documented, a wide variety of lesions afflict it. Conditions and entities that affect the female breast also occur in the male breast. However, lobular lesions are seldom seen in male breasts because of absence of terminal differentiation induced by progesterone. So far, there have been very few studies on the spectrum of male breast lesions and most of them are done either on aspiration smears or on biopsies. Therefore, in the present study, we aimed to analyse the spectrum of different types of male breast lesions at our tertiary care centre both on aspiration cytology smears and histological specimens as well as biopsies.
Objectives:
To study the spectrum of male breast lesions encountered in histopathology and cytology lab.
Study Design:
Data on male breast lesions between 2010 to 2015 were retrieved from the records of Kasturba Medical College, Mangalore. The cytological and histological features were studied and the number of benign and malignant cases recorded. Cytohistologic correlation, wherever available was done. Immunohistochemistry was studied in malignancies wherever available.
Results:
Out of 7700 breast lumps retrieved, 120 (1.55%) male breast lesions were identified. Of these, 54 were diagnosed by FNAC and 76 lesions on surgical specimens. On FNAC, 49 were benign and 5 malignant. The 76 cases diagnosed on histology had 70 benign and 6 malignant lesions. The benign lesions were gynecomastia, inflammatory masses, fibroadenoma and intraductal papillomas. Malignant lesions included infiltrating ductal carcinoma (NOS), papillary and metastatic carcinoma with 60% showing ER positivity. Ten of these cases had both cytology and histology.
Conclusion:
While gynaecomastia and invasive ductal cancer were the commonest lesions encountered in the male breast, there were other rarer benign and malignant lesions.
Calibration of the local magnitude scale (Ml )for Central Southern Africa
Authors: Shumba Blessing T , Midzi Vunganayi , Manzunzu Brassnavy , Maritinkole Joseph R 
Published: January 2023

Abstract
The Central Southern Africa is an area of moderate seismic activity generally caused by the presence of the East Africa Rift System. To improve the quantification of seismicity in this region, we propose a local magnitude scale (Ml, based on the original Richter definition to be used by the Zimbabwe and Botswana national networks. The magnitude scale is developed using 854 seismic events that occurred between 1997 - 2000 and 2013 - 2018. These events were recorded by 61 broadband seismic stations located in Botswana, Zimbabwe, and South Africa. We evaluated 6128 traces of zero to peak maximum amplitude, recorded on the horizontal channel from simulated Wood-Anderson seismograms. All 6128 maximum amplitude measurements were inverted simultaneously to determine the attenuation constants. The resultant Ml is defined as Ml = logA+0.80log(R)+0.00086R-1.37 ± S in which A is ground displacement amplitude determined from instrument corrected synthetic Wood-Anderson seismograms in nanometres, R is the epicentral distance (km), and S is the station correction. Station corrections were determined for all stations during the regression analysis resulting in values ranging between -0.44 to + 0.31. The range in station corrections suggests a strong influence of local site effects on the amplitude of the seismic signal. Without station correction, the overall standard deviation of the magnitude residuals using our magnitude relation is 0.32 with a variance of 0.10, while using station corrections, the standard deviation and variance improved to 0.17 and 0.02 respectively. There is 80% reduction in variance when our relation is used together with station corrections. A comparison of our local magnitude relation with published $mb}$ relationships for Southern Africa shows that these two magnitude scales are almost equivalent. The Ml equation for Central Southern Africa derived in this study has good correlation with mb values reported by the ISC and NEIC and attains systematically lower magnitude values than the South African relationship.
Sub-zero milling of Ti-6Al-4V – Impact of the cutting parameters on the resulting forces, tool wear, and surface quality
Authors: Gutzeit Kevin , Bulun Georgis , Stelzer Gerhard , Kirsch Benjamin , Seewig Jörg , Aurich Jan C. 
Published: January 2023

Abstract
Due to an excellent ratio of high strength and low density, Ti-6Al-4V is suitable for many industrial applications, especially in the aerospace industry. However, Ti-6Al-4V is also characterized as a hard to-cut material. This is mainly attributed to its very low thermal conductivity and high chemical reactivity, especially at elevated temperatures. Machining Ti-6Al-4V leads to high cutting temperatures and thermal loads of the tools within the cutting zone. This enhances a rapidly progressing, thermo-chemical induced tool wear reducing tool life and productivity. To enhance the cutting performance, suitable cooling strategies are a necessity to reduce the thermal load and hence to improve the machinability of Ti-6Al-4V. A novel, highly efficient cooling approach is to apply sub-zero metalworking fluids (MWF) at liquid state but at supply temperatures well below 0°C. These sub-zero MWF inhibit high cooling effects due to their low supply temperature in superposition with a beneficial wetting behavior. Within this paper, the application of a sub-zero cooling strategy is investigated and compared to a cryogenic CO2 cooling. The performance of both cooling strategies is analyzed when milling Ti-6Al-4V by systematically varying the cutting parameters and the milling strategy. The milling process is described on the basis of the occurring forces, the resulting wear and the surface quality. The results show that the sub-zero cooling outperforms the cryogenic CO2 cooling, especially at elevated cutting parameters and unfavorable cutting conditions. Less tool wear and an overall better surface quality are observed for sub-zero milling when being compared to cryogenic milling.
A Comprehensive Multiomics Analysis Identified POLQ as a Promising Prognostic Biomarker in Pan-Cancer
Authors: Yang Fanchun , Wu Yuliang , Huang Wei , Luo Ning , Liu Shupeng , Cheng Zhongping 
Published: January 2023

Abstract
Background
DNA polymerase (POLQ) is a unique A-family polymerase that is correlated with homologous recombination and plays a vital role in maintaining the stability of the genome. Tumor immune microenvironment (TIME) plays an important role in the occurrence and development of tumor. POLQ is associated with TIME and a poor prognosis. However, the roles of POLQ in human cancers are still unclear. Hence, studying POLQ maybe provide a new strategy for tumor-immune therapy.
Methods
The mRNA expression data and clinical information of cancer were downloaded from TCGA and GTEx. We explored the prognosis, mutation, copy number variation (CNV) and single nucleotide variations (SNV), microsatellite instability (MSI), tumor mutational burden (TMB), mismatch repair (MMR) gene mutation levels and DNA methyltransferase expression, immune infiltration, enrichment analysis and pathway, and drug sensitivity analysis via Kaplan-Meier curves, cBioPortal, GSCA, TCGA, TIMER, The LinkedOmics database and Multiomics Data.
Results
POLQ expression was associated with adverse outcomes in uterine corpus endometrial carcinoma (UCEC), kidney renal papillary cell carcinoma (KIRP) and liver hepatocellular carcinoma (LIHC) patients. Additionally, our study revealed that genomic alteration of POLQ was associated with tumorigenesis in multiple tumors and POLQ was correlated with MSI, TMB, MMR gene mutation and DNA methyltransferase expression. POLQ expression was positively correlated with the infiltration of immune cells including B cells, CD4+ T cells, CD8+ T cells, neutrophils, macrophages, and dendritic cells, especially in kidney renal clear cell carcinoma (KIRC), thyroid carcinoma (THCA). And POLQ expression was positively correlated with the immune score and immune checkpoint in KIRC and THCA. In particular, POLQ can increase the resistance to drug, especially to PAPR inhibitors.
Conclusion
POLQ could be a novel biomarker and a potential target for immune-related therapy in pan-cancer.
The activation of AIM2/Caspase-1/GSDMD pathway contributes to pyroptosis of keratinocytes in Stevens-Johnson syndrome/toxic epidermal necrolysis
Authors: Yang Lu , Shou Yanhong , Li Feng , Du Juan , Zhu Xiao-hua , Wang Shang-shang , Xie Lin , Zhou Li-juan , Zhou Jia-qing , Yang Yong-sheng , Xu Jinhua 
Published: January 2023

Abstract
Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN) are severe cutaneous adverse drug reactions, rare but life-threatening, characterized by massive keratinocyte death and development of a systemic inflammatory response. Pyroptosis is a lytic form of pro-inflammatory programmed necrotic cell death which participates in the pathogenesis of various inflammatory diseases, it depends on activation of inflammasomes such as NLRP3/NALP1/AIM2/NLRC4 and inflammatory caspases (caspase 1/4/5), subsequently it is executed by pore-forming protein of the gasdermin family, resulting in releases of inflammatory cytokines such as IL-1β, IL-18. However, does pyroptotic machinery exist in the SJS/TEN remains open. In our study, we present evidence for the involvement and mechanism of pyroptosis in SJS/TEN keratinocytes. Inflammatory cytokines TNF-α and IFN-γ participating in keratinocyte pyroptosis through strengthening of cytoplasmic dsDNA/AIM2/Caspase-1/GSDMD pathway were identified in vivo and in vitro. Further, we observed that all of the four small molecular pyroptosis inhibitors including Z-YVAD-FMK，dimethyl fumarate (DMF), necrosulfonamide (NSA) and disulfiram caused a significant inhibition of pyroptosis in human primary keratinocytes, and significantly downregulated the release of pyroptosis-related inflammatory cytokines IL-1β and IL-18. These discoveries expand our understanding of the pathogenesis of SJS/TEN and it is hoped that this could facilitate the development of new therapeutics for the treatment of SJS/TEN patients with activated pyroptosis in keratinocytes.
Divergent epigenetic responses to birth asphyxia in severe mental disorders
Authors: Wortinger Laura , Stavrum Anne-Kristin , Shadrin Alexey , Szabo Attila , Rukke Sondre Høeg , Nerland Stener , Smelror Runar , Jørgensen Kjetil , Barth Claudia , Andreou Dimitrios , Weibell Melissa , Djurovic Srdjan , Andreassen Ole , Thoresen Marianne , Ursini Gianluca , Agartz Ingrid , Hellard Stephanie Le 
Published: January 2023

Abstract

Epigenetic modifications influenced by environmental exposures are molecular sources of phenotypic heterogeneity found in schizophrenia and bipolar disorder and may contribute to shared etiopathogenetic mechanisms of these two disorders. Newborns who experienced birth asphyxia have suffered reduced oxygen delivery to the brain around the time of birth, which increases the risk of later psychiatric diagnosis. This study aimed to investigate DNA methylation in blood cells for associations with a history of birth asphyxia, a neurologically harmful condition occurring within the biological environment of birth. We utilized prospective data from the Medical Birth Registry of Norway to identify incidents of birth asphyxia in 643 individuals with schizophrenia or bipolar disorder and 676 healthy controls. We performed an epigenome wide association study to distinguish differentially methylated positions associated with birth asphyxia. We found an interaction between methylation and exposure to birth asphyxia on case–control status, wherein having a history of birth asphyxia was associated with an increase of methylation in healthy controls and a decrease of methylation in patients on 4 regions of DNA important for brain development and function. The differentially methylated regions were observed in genes involved in oligodendrocyte survival and axonal myelination and functional recovery(LINGO3); assembly, maturation and maintenance of the brain (BLCAP;NNATandNANOS2) and axonal transport processes and neural plasticity (SLC2A14). These findings are consistent with the notion that an opposite epigenetic response to birth asphyxia, in patients compared with controls, may contribute to molecular mechanisms of risk for schizophrenia and bipolar disorder.
Erector spinae muscle area and the ratio of the computed tomography values of the liver and spleen are associated with frailty in older patients with diabetes: A cross-sectional study
Authors: Sato Motoya , Tamura Yoshiaki , Murao Yuji , Yorikawa Fumino , Katsumata Yuu , Watanabe So , Zen Shugo , Kodera Remi , Oba Kazuhito , Toyoshima Kenji , Chiba Yuko , Araki Atsushi 
Published: January 2023

Abstract
Background
Older patients with diabetes mellitus are more susceptible to frailty. Although some imaging markers of appendicular skeletal muscle mass obtained using dual-energy X-ray absorptiometry or computed tomography (CT) imaging can reflect frailty status, the association between imaging indices obtained by abdominal CT scans and frailty in older inpatients has not been reported.
Methods
A total of 151 older inpatients with diabetes mellitus (median age, 79 years; men, 42%) who underwent abdominal CT scans close to the admission were studied to examine the associations between abdominal CT indices and frailty. We used two frailty definitions: the modified Cardiovascular Health Study (mCHS) criteria and Kihon Checklist (KCL) criteria. Using the imaging analysis software SYNAPSE VINCENT®, we compared the areas of four truncal muscles (erector spinae, iliopsoas, rectus abdominis, and abdominal oblique muscles) and the ratio of the CT values of the liver and spleen (L/S) between frail and non-frail patients. The muscle areas that showed the strongest associations with frailty were also investigated in relation to grip strength and walking speed. Finally, we performed multivariate binominal logistic regression analysis to assess the independent associations of muscle areas and L/S with the prevalence of frailty.
Results
The prevalence of frailty defined by the mCHS and KCL criteria was 55% and 52%, respectively. The area of the erector spinae muscle was most significantly associated with frailty, and was significantly smaller in mCHS-defined frail patients of both sexes and in men with KCL-defined frailty. The erector spinae muscle area was also positively correlated with grip strength and walking speed. In contrast, the L/S ratio was higher in men with KCL-defined frailty. Multivariate logistic regression analyses revealed that the area of the erector spinae muscle was independently associated with mCHS-defined frailty in women, and the L/S ratio was associated with KCL-defined frailty in men.
Conclusions
The erector spinae muscle area and low liver fat could be indices of frailty in older patients with diabetes.
Effect of Square Dance Exercise on Middle-aged and Older Women With Persistent Postural-Perceptual Dizziness (PPPD)
Authors: tang Bo , jiang wei , zhang chuang , tan hong , luo minghua , he yuqin , yu xiaojun 
Published: January 2023

Abstract
Background: Persistent postural-perceptual dizziness (PPPD) is a disorder of vestibular dysfunction in which chronic dizziness leads to limitations in daily life. Although pharmacology, vestibular rehabilitation, and cognitive behavioral therapy have been suggested to have some efficacy, they have certain limitations. Some patients with PPPD report that square dance can effectively relieve the symptoms of dizziness and instability, and their mood also improves. However, to date, there has been no research about the effect of square dance Exercise on people of PPPD，not to mention the middle-aged and older women who are more interested in square dance.
Objective: To evaluate the effects of square dance on the subjective sensations of dizziness, balance enhancement, anxiety, and depressive symptom regulation in middle-aged and older women with PPPD.
Materials and Methods: In this trial, a total of 124 patients diagnosed with PPPD were enrolled, among whom 64 were randomly assigned to square dance training as the experimental group (EG), and the other 60 cases were the control group (CG) without square dance training. To evaluate the effect of square dancing on middle-aged and elderly women with PPPD, data from the Dizziness Handicap Inventory (DHI), Hospital Anxiety and Depression Scale (HADS), Active-specific Balance Confidence Scale (ABC), and Vestibular Disorder Activities of Daily Living Scale (VADL) were collected and compared at the beginning and at three and six months of the trial.
Results: Before the trial, there were no significant differences between the EG and CG. Compared with baseline measures, DHI, HADS, ABC, and VADL scores improved as the experiment progressed, and the improvements were more pronounced in the EG.
Conclusion: Square dance has a positive impact on the subjective sensation of dizziness, balance enhancement, anxiety, and depressive symptom regulation in middle-aged and older women with PPPD.
FDG-PET/CT for lymph node staging in bladder cancer treated with radical cystectomy
Authors: Pihl Vilhelm , Markus Maria , Abrahamsson Johan , Bläckberg Mats , Hagberg Oskar , Kollberg Petter , Simoulis Athanasios , Trägårdh Elin , Liedberg Fredrik 
Published: January 2023

AbstractBackground18F-Flourodeoxyglucose positron emission combined with computed tomography (FDG-PET/CT) has been proposed to improve preoperative staging in patients with bladder cancer subjected to radical cystectomy (RC). Objective Our aim was to assess the accuracy of FDG-PET/CT for lymph node staging compared to lymph node status in the surgical lymphadenectomy specimen obtained at RC, and to explore potential factors associated with false positive FDG-PET/CT results. Design, setting and participants Consecutive patients with bladder cancer undergoing RC with extended lymph node dissection between 2011 and 2019 without preoperative chemotherapy in a tertial referral cystectomy unit were included in the study. Outcome measurements and statistical analyses Sensitivity, specificity, positive and negative predictive values, and likelihood ratios were calculated. Potential factors investigated for association with false positive FDG-PET/CT were; bacteriuria within four weeks prior to FDG-PET/CT, Bacillus Calmette-Guerin (BCG) treatment within 12 months prior to FDG-PET/CT and transurethral resection of bladder tumor (TURB) within four weeks prior to FDG-PET/CT. Results Among 159 patients included for analysis, 46 (29%) were clinically node positive according to FDG-PET/CT. The sensitivity and specificity for detection of lymph node metastasis were 50% and 82%, respectively, and the corresponding positive predictive and negative predictive values were 59% and 76%. Positive and negative likelihood ratios were 2.8 and 0.6, respectively. No association were found between bacteriuria, previous BCG treatment or TURB within 28 days and false positive FDG-PET/CT results. Conclusions Preoperative FDG-PET/CT prior to RC had a clinically meaningful high specificity (82%) but lower sensitivity (50%) for detection of lymph node metastases compared to lymph node status in an extended pelvic lymphadenectomy template. We could not identify any factors associated with false positive FDG-PET/CT outcomes.
Indoor Positioning Design Based on HCC in the Background of Mobile Edge ComputingIndoor Positioning Design Based on HCC in the Background of Mobile Edge Computing
Authors: Ge Tai 
Published: January 2023

Abstract
In the subject of human-centered computing (HCC), achieving accurate location in an indoor setting is a crucial research problem and a hotspot for research. In comparison to WiFi, GPS, and Bluetooth location technologies, the radio frequency identification (RFID) technology obviously has benefits. However, the fixed path loss coefficient in the indoor positioning algorithm based on RFID cannot accurately reflect the complex and mutable properties of inside settings, leading to significant indoor positioning mistakes and sluggish speeds. This research suggests an indoor positioning system based on Edge Computing (EC) to improve the precision and responsiveness of indoor positioning. First, the indoor signal strength is calculated using RFID. Next, the output is sent to a neural network, which outputs the path loss coefficient. Finally, the EC is used to create a more effective indoor positioning system design. According to experiments, the suggested method can more correctly reflect inside environment signal changes and increase indoor location accuracy. This solution effectively satisfies the requirements for indoor real-time positioning even after being deployed to EC.
Relationship between Determinant Factors of Tooth Decay and Filling in Indonesia (Mapping Determinant Factors using Geographic Information System)
Authors: Lestari Ayu Asri , Darwita Risqa Rina , Adiatman Melissa , Rahardjo Anton , Ramadhani Atik , Bramantoro Taufan 
Published: January 2023

AbstractBackground One of the goals of Indonesia's participation in sustainable development goals to improve its health status. Efforts made to achieve health improvement are increasing the availability of healthcare facilities so people can easily access and get treatment for dental and oral health. This study aimed to determine the relationship between sociodemographic and healthcare services factors that affect tooth decay and filling in Indonesia. Methods A cross-sectional study using secondary data from Basic Health Research 2018 as classified based on WHO age as much 14.031 subjects are sociodemographic factors, utilization of dental visits, total decay, and filling. Health Facility Research 2019 data using 17.741 healthcare facilities. The number of dentists as much as 22.926 data through the Indonesia Medical Council on December 2021. These variables were tested statistically and mapped using QGIS. Results Mann-Whitney test showed a significant difference (p < 0,05) between the female sex, living in the urban area towards tooth decay and filling. Kruskal-Wallis test showed a significant difference (p < 0,05) between groups of informal, formal workers with unemployment, educational level in 35–44 years group between no school and elementary-high school with diploma 3-college and group of 65 + years between all groups, and also frequency utilization towards tooth decay and tooth filling had significant statistics. Spearman test showed a correlation statistically (p < 0,05) between the number and ratio of healthcare facilities and dentists towards tooth decay and filling. Conclusion In this study, there is a relationship between sociodemographic factors and healthcare services that affect tooth decay and filling. Efforts to equitable distribution of healthcare facilities and dentists, as well as an intervention to increase utilization by looking at all aspects of sociodemographic characteristics.