bluuebunny/crossref_metadata_2025_split huggingface dataset:
The construction, reliability, and evidence of validity of a scale to measure new technologies by Spanish psychologist
Authors: Ramos-Álvarez Rodolfo , Sánchez-Martín Milagrosa , Rodríguez-Ruiz Mª-Mercedes , Fausor Rocío 
Published: June 2023

In this study we present the construction and analysis of a questionnaire for analyze the use of new technologies (NNTT) by psychology professionals, based on a sample of 1759 psychologists.). The final version composed by 36 items was generated from a bibliographic review on the new technologies applied to psychology. Exploratory factor analysis of selected items based on a randomized sample (n = 853) indicated the presence of five factors related to 1.- Online storage; 2.- Use of basic office and internet tools; 3.- Communication routes with the patient; 4.- Basic and advanced knowledge of programming and evaluation languages; 5.- Psychological interventions through NNTT. Validity of the 5-factor structure was supported by confirmatory factor analysis carried out with the remaining sample (n = 906). The results of reliability (internal consistency) and validity were adequate. Significant differences are found by sex, men obtain higher scores in both factor 1 and 3. The developed questionnaire is a valid and reliable instrument to measure the proposed construct.
En este estudio presentamos la construcción y análisis de un cuestionario para medir el uso de las nuevas tecnologías (NNTT) por los profesionales de la psicología, basándonos en una muestra de 1759 psicólogos y psicólogas. El conjunto de 36 ítems fue generado a partir de una revisión bibliográfica sobre las nuevas tecnologías aplicadas a la psicología. El análisis factorial exploratorio de los ítems seleccionados, basado en la muestra aleatorizada (n = 853), indicó la presencia de 5 factores: 1.- Almacenamiento online; 2.- Uso de herramientas básicas de ofimática e internet; 3.- Vías de comunicación con el paciente; 4.- Conocimiento básico y avanzado de lenguajes de programación y evaluación; 5.- Intervención psicológica mediante NNTT. La validez de la estructura fue apoyada por el análisis factorial confirmatorio efectuado con la muestra restante (n = 906). Los resultados sobre fiabilidad de la escala (consistencia interna) fueron adecuados. Se encuentran diferencias significativas por sexo, los hombres obtienen mayor puntuación tanto en el factor 1 como en el 3. El cuestionario desarrollado es un instrumento válido y fiable para medir el constructo planteado.
Revisiting the Ambivalent Sexism Inventory’s Adolescent and Brief Versions: Problems, solutions, and considerations
Authors: Juarros-Basterretxea Joel , Ocampo Nadia Yazmin , Rojas-Solis José Luis , Rodríguez-Díaz Francisco Javier , García-Cueto Eduardo 
Published: June 2023

The Ambivalent Sexism Inventory (ASI) has been widely used in applied research and sometimes modified versions have been proposed. The current research aimed to test the factor validity and reliability of the ASI for adolescents (ASI-A) and Brief ASI (B-ASI) versions in the adolescent population. Two analogue samples of Mexican secondary students (Study 1: n1 = 975; Study 2: n2 = 1020) composed the sample. The ASI-A showed that the two-dimension model omitting items 1 to 4 is the most recommendable model and it presents an acceptable fitting to the data (Study 1). The B-ASI bidimensional model showed an appropriate fitting to the data and no modifications were required (Study 2). The ASI-A is a valid measure of ambivalent sexism when some of its items are omitted, but the demonstrated validity of the original items in the adolescent population supports that there was no theoretical or empirical reason for developing a specific version for adolescents of the ASI.
El inventario de sexismo ambivalente (ASI) es frecuentemente utilizado en la investigación aplicada, lo que ha llevado a que en ocasiones se propongan versiones modificadas del mismo. La presente investigación tuvo por objetivo evaluar la validez factorial y la fiabilidad de la versión para adolescentes (ASI-A) y la versión breve (B-ASI) de este inventario en población adolescente. Se utilizaron los datos de dos muestras análogas de estudiantes de secundaria de México (estudio 1: n1 = 975; estudio 2: n2 = 1020). El modelo de dos dimensiones omitiendo los ítems 1 a 4 resultó ser el más recomendable en el caso del ASI-A presentando un ajuste aceptable (estudio 1). El modelo bidimensional también result ser el más apropiado en el caso del B-ASI al obtener un ajuste adecuado a los datos sin requerir ninguna modificación (estudio 2). El ASI-A es un instrumento de medida válido cuando algunos de los ítems son omitidos, pero la demostrada validez de la versión original de la escala incluso en población adolescente cuestiona la pertinencia teórica y empírica para desarrollar una versión específica para adolescentes.
Intake of Fruits and Vegetables as Self Prescribed Weight Reducing and DASH Diets among Obese-Hypertensive Individuals Attending Irrua Specialist Teaching Hospital Irrua, Edo State, Nigeria
Authors: Babangida Peter M. , Ofili Charles , Peters Esegbue , Nwose Ezekiel U. 
Published: June 2023

Background: Five servings of fruits and vegetables each day, along with relatively unprocessed whole grains or legumes with each meal, are essential for reducing the risk of obesity, hypertension and other related non communicable diseases. While being low or relatively low in calories, fruits and vegetables include a large amount of dietary fiber and a range of micronutrients, antioxidants and phytochemicals which are all essential for health.
Aims: To investigate the intake of fruits and vegetables as self prescribed weight reducing and DASH (Dietary Approach to Stop Hypertension) diets among obese - hypertensive individuals attending Irrua Specialist Teaching Hospital Irrua, Edo State.
Methods: A descriptive cross sectional study design was used with a sample size of 440 obese hypertensive individuals (with body mass index of = or > 30Kg/m2 and blood pressure of = or > 140/90mmHg). Questionnaires, personal interviews and anthropometric measurements were used to collect data using purposive sampling technique. Data collected were analyzed using Statistical Package for the Social Sciences (IBM SPSS) 22 Version.
Results: A total of 440 respondents were used in the study and data were elicited from all of this number giving a 100% response rate. A total of 242 (55.0%) and 215 (48.9%) of the respondents consumed fruits and vegetables only one to two days per week with only 36 (8.2%) and 26 (5.9%) consuming fruits and vegetables every day.
Conclusion: It can be concluded based on the key findings of this study that there is statistically significant mean difference in fruits and vegetables consumption amongst obese - hypertensive individuals attending Irrua Specialist Teaching Hospital, Edo State, Nigeria (p<0.05).
Biosimilars for the Treatment of Psoriasis
Authors: Phan Duc Binh , Elyoussfi Sarah , Stevenson Michael , Lunt Mark , Warren Richard B. , Yiu Zenas Z. N. 
Published: May 2023

ImportanceBiosimilars have the potential to reduce costs for the management of moderate-to-severe psoriasis compared with originators. However, the extrapolation of evidence enables the approval of a biosimilar for use in indications held by the originator without directly being studied in clinical trials. Thus, biosimilars can be approved for psoriasis based on extrapolated evidence from other diseases. The availability of evidence for the effectiveness and safety of biosimilars for the treatment of psoriasis is therefore unclear.ObjectiveTo compare the efficacy/effectiveness and safety of biosimilars with originator biologics for the treatment of patients with psoriasis.Evidence ReviewMEDLINE, EMBASE, Cochrane Library, ClinicalTrials.gov, and The European Union Clinical Trials Register were searched in August 2022. Eligible studies were appraised using the Cochrane Risk of Bias 2 and ROBINS-I tools. All analyses were conducted from September 2022 to November 2022.FindingsFourteen trials (10 adalimumab, 2 etanercept, 1 infliximab, and 1 ustekinumab) and 3 cohort studies (1 adalimumab, 1 etanercept, 1 infliximab and etanercept) were included. Twelve trials compared biosimilars with originators in originator-naive patients (starters), and 11 trials compared switching from originator to biosimilar (switchers) with continuous originator treatments. There was no clinically or statistically significant difference in rates of achieving 75% improvement in Psoriasis Area and Severity Index scores and risks of adverse events (AEs) at week 16 and week 52 between the comparators. Two cohort studies showed no difference in effectiveness and safety outcomes between originators and biosimilars, whereas 1 study reported more AEs in patients who switched to biosimilars of adalimumab at 12 months. Three trials showed low risk of bias, whereas 11 trials had moderate risk of bias. All cohort studies had moderate to high risk of bias.Conclusions and RelevanceIn this systematic review, there was no clinically or statistically significant difference in the efficacy and safety between biosimilars and originators for the treatment of patients with psoriasis. Most of the available evidence was based on randomized clinical trials, although high-quality real-world evidence was lacking. Future studies are needed to examine the long-term effectiveness and safety of biosimilars for the treatment of patients with psoriasis.
Weekly Adaptive Radiotherapy vs Standard Intensity-Modulated Radiotherapy for Improving Salivary Function in Patients With Head and Neck Cancer
Authors: Castelli Joël , Thariat Juliette , Benezery Karen , Hasbini Ali , Gery Bernard , Berger Antoine , Liem Xavier , Guihard Sébastien , Chapet Sophie , Thureau Sébastien , Auberdiac Pierre , Pommier Pascal , Ruffier Amandine , Perrier Lionel , Devillers Anne , Campillo-Gimenez Boris , de Crevoisier Renaud 
Published: June 2023

ImportanceXerostomia is a major toxic effect associated with intensity-modulated radiotherapy (IMRT) for oropharyngeal cancers.ObjectiveTo assess whether adaptive radiotherapy (ART) improves salivary function compared with IMRT in patients with head and neck cancer.Design, Setting, and ParticipantsThis phase 3 randomized clinical trial was conducted in 11 French centers. Patients aged 18 to 75 years with stage III-IVB squamous cell oropharyngeal cancer treated with chemoradiotherapy were enrolled between July 5, 2013, and October 1, 2018. Data were analyzed from November 2021 to May 2022.InterventionsThe patients were randomly assigned (1:1) to receive standard IMRT (without replanning) or ART (systematic weekly replanning).Main Outcomes and MeasuresThe primary end point was the frequency of xerostomia, measured by stimulating salivary flow with paraffin. Secondary end points included salivary gland excretory function measured using technetium-99m pertechnetate scintigraphy, patient-reported outcomes (Eisbruch xerostomia-specific questionnaire and the MD Anderson Symptom Inventory for Head and Neck Cancer questionnaire), early and late toxic effects, disease control, and overall and cancer-specific survival.ResultsA total of 132 patients were randomized, and after 1 exclusion in the ART arm, 131 were analyzed: 66 in the ART arm (mean [SD] age at inclusion, 60 [8] years; 57 [86.4%] male) and 65 in the standard IMRT arm (mean [SD] age at inclusion, 60 [8] years; 57 [87.7%] male). The median follow-up was 26.4 months (IQR, 1.2-31.3 months). The mean (SD) salivary flow (paraffin) at 12 months was 630 (450) mg/min in the ART arm and 584 (464) mg/min in the standard arm (P = .64). The mean (SD) excretory function of the parotid gland at 12 months, measured by scintigraphy, improved in the ART arm (48% [17%]) compared with the standard arm (41% [17%]) (P = .02). The 2-year-overall survival was 76.9% (95% CI, 64.7%-85.4%) in both arms.Conclusions and RelevanceThis randomized clinical trial did not demonstrate a benefit of ART in decreasing xerostomia compared with standard IMRT. No significant differences were found in secondary end points except for parotid gland excretory function, as assessed by scintigraphy, or in survival rates.Trial RegistrationClinicalTrials.gov Identifier: NCT01874587
Bibliometric Analysis of Ophthalmic Journals
Authors: Nichols Jason J. , Morgan Philip B. , Jones Lyndon W. , Efron Nathan 
Published: June 2023

ImportanceThe primary vehicle for reporting and testing advances in eye care is refereed ophthalmic journals, which can be characterized using targeted bibliometric analyses.ObjectiveTo identify all ophthalmic journals and evaluate citation metrics relating to articles, journals, authors, institutions, and countries published therein.Design and SettingA bibliometric analysis was undertaken of all ophthalmic journals included in the Scopus database (Elsevier). The search was restricted to all article types published in ophthalmic journals in English from inception through November 18, 2022. After excluding general medical journals, journals published in a language other than English, and spurious titles unrelated to the ophthalmic field, the Scopus database was found to list 335 ophthalmic journal titles that have published 471 184 articles, constituting the data set for this analysis. The 20 most highly cited articles were identified. Rank-order lists by article count were assembled for journals, authors, institutions, and countries.Main Outcomes and MeasuresAn h-index for ophthalmic journal articles was derived from citations and article counts for each constituent of each category.ResultsThe h-index for ophthalmic journal articles was determined to be 494. The journal with the highest h-index was Ophthalmology (h-index, 297). The journal with the greatest number of articles was American Journal of Ophthalmology (38 441 articles). The most highly cited article was by Quigley and Broman, 2006 (5147 citations), concerning the epidemiology of glaucoma. The author with the highest h-index for ophthalmic journal articles was Ronald Klein, MD (h-index, 126), and the most prolific was Carol L. Shields, MD (1400 articles). Johns Hopkins University (h-index, 215) was the institution with the highest h-index for ophthalmic journal articles, and Harvard University was the most prolific (10 071 articles). The United States was the nation with the highest h-index for ophthalmic journal articles (h-index, 444) and was the most prolific (180 017 articles).Conclusions and RelevanceIn this study, the most highly cited articles published in ophthalmic journals were revealed, as well as the leading journals, authors, institutions, and countries. While excluding ophthalmology articles in general medical journals, this investigation affords a means of identifying highly cited authors, institutions, and countries which individuals or institutions can use as a guide regarding contributions to the field.
Epigenome‐wide DNA methylation analysis of myasthenia gravis
Authors: Lin Jingjing , Tao Linshuang , Deng Lu , Zhou Ruyi , Lou Shuyue , Chen Songfang , Chen Xuanyu , Lu Chunxing , Li Peijun , Hu Beilei 
Published: May 2023

Myasthenia gravis (MG) is a common neuromuscular junction disorder and autoimmune disease mediated by several antibodies. Several studies have shown that genetic factors play an important role in MG pathogenesis. To gain insight into the epigenetic factors affecting MG, we report here genome‐scale DNA methylation profiles of MG. DNA was extracted from eight MG patients and four healthy controls for genome‐wide DNA methylation analysis using the Illumina HumanMethylation 850K BeadChip. Verification of pyrosequencing was conducted based on differential methylation positions. Subsequently, C2C12 and HT22 cell lines (derived from mouse) were treated with demethylation drugs. Transcribed mRNA of the screened differential genes was detected using quantitative real‐time PCR. The control and MG group were compared, and two key probe positions were selected. The corresponding genes were CAMK1D and CREB5 (P < 0.05). Similarly, the myasthenic crisis (MC) and non‐MC group were compared and four key probe positions were selected. The corresponding genes were SAV1, STK3, YAP1, and WWTR1 (P < 0.05). Subsequently, pyrosequencing was performed for verification, revealing that hypomethylation of CAMK1D was significantly different between the MG and control group (P < 0.001). Moreover, transcription of CREB5, PKD, YAP1, and STK3 genes in the C2C12 cells was downregulated (P < 0.05) after drug treatment, but only YAP1 mRNA was downregulated in HT22 cells (P < 0.05). This is the first study to investigate genome‐scale DNA methylation profiles of MG using 850 K BeadChip. The identified molecular markers of methylation may aid in the prevention, diagnosis, treatment, and prognosis of MG.
In Situ Co‐transformation of Reduced Graphene Oxide Embedded in Laser‐Induced Graphene and Full‐Range On‐Body Strain Sensor
Authors: Yoon Hyosang , Lee Kyoungryul , Shin Hanho , Jeong Seongeun , Lee Yi Jae , Yang Sungwook , Lee Soo Hyun 
Published: June 2023

AbstractOn‐body strain information provides various indicators such as heart rate, physiological pulse, voice waveform, respiratory rate, and body motion status. Recent advances in wearable strain sensors using nanomaterials have significantly enhanced sensor performance with regard to sensitivity, detectable range, and response time. However, it is still challenging to obtain all types of body strain information, from small vibrations to joint movements, using one type of sensor. Herein, a full‐range on‐body strain (FROS) sensor covering ultrasmall‐to‐large strains such as vocal vibration and joint movement is reported. To achieve an ultrawide detectable range, reduced graphene oxide (rGO)‐embedded laser‐induced graphene (LIG) is synthesized by laser engraving on a graphene oxide (GO)‐embedded polyimide (PI) complex film. An rGO‐LIG homostructure based on sp2‐carbons is photothermally reconstructed from the GO‐PI heterostructure in a complex film by in situ co‐transformation and then transferred to an elastomer substrate. The fabricated FROS sensor successfully performs on‐body strain monitoring of various indicators, such as physiological pulse, vocal sound waveform, and body movement, as well as American sign language translation. Furthermore, it is believed that this rGO‐LIG homostructure‐based material synthesized by in situ co‐transformation can potentially provide novel functionalities in fields such as wearable electronics, humanoid, soft robotics, and intelligent prosthetics.
Autonomous Self‐Sustained Liquid Crystal Actuators Enabling Active Photonic Applications
Authors: Zheng Ren , Ma Lingling , Feng Wei , Pan Jintao , Wang Zeyu , Chen Zhaoxian , Zhang Yiheng , Li Chaoyi , Chen Peng , Bisoyi Hari Krishna , Li Bingxiang , Li Quan , Lu Yanqing 
Published: May 2023

AbstractAdvances in biomimicry have led to the rise of advanced robotics, posing promising revolutions across a variety of fields. Programmable self‐sustained actuation in nature, such as human's heart beating, bird's wingbeats, and penguin's waddling, are intriguing and inspiring but challenging for device innovation, which hinders the emergence of autonomous self‐feedback applications, especially in optics and photonics. Herein, the design, fabrication, and operation of crosslinked liquid crystal actuators are described that combine the programming of microstructures and the engineering of macroscopic shape morphing for active optics and photonics. The actuators consist of twisted nematic liquid crystal molecules with both elastic and optical anisotropies, resulting in large bending deformations in response to heat. Programmable bending motions and self‐sustained waddling oscillations are demonstrated, further contributing to the achievements of dynamic 2D beam steering and self‐sustained light field modulation. It is envisioned that these actuators with self‐sustained performances without requiring turning the stimulus on‐off will find applications in autonomous active optical systems, photonic applications, as well as self‐governing robotics with the core feature of thermo‐mechanical‐optical transduction.
Modeling of Void‐Mediated Cracking and Lithium Penetration in All‐Solid‐State Batteries
Authors: Wang Wei , Wang Jiaxuan , Lin Chen , Ruan Haihui 
Published: June 2023

AbstractAll‐solid‐state batteries (ASSBs) are expected to have an exceptional energy density and safety owing to the possibilities of direct usage of lithium as an anode and the suppression of dendrites by a solid‐state electrolyte (SSE). However, recent experiments unveil discharging‐induced voids in lithium‐SSE interfaces and charging‐induced cracks in SSE, wherein lithium penetration occurs. To avoid such cell failures, a theoretical model rendering high‐credibility simulations is needed to assist ASSB designs. Herein, such a model coupling the electrochemical processes and mechanical responses of an ASSB are proposed, in which the kinetics of voids and cracks are the key ingredients. Numerical simulations based on the model reveal that void growth is the result of stripping with disparate diffusivity in the surface layer and the bulk of lithium. They bring about the non‐uniform distribution of Li+ during electroplating, a damage zone near the interface, SSE cracking, and then lithium plating in the cracks. It is noted that the cracks and lithium dendrites revealed by the simulations are very similar to those observed in in situ experiments and that a high stack pressure cannot inhibit cracking and lithium penetration. Instead, suitable lateral compressive stresses can prevent SSE from cracking and therefore inhibit lithium dendrites.
Defining Integrin Tension Required for Chemotaxis of Metastatic Breast Cancer Cells in Confinement
Authors: Kim Young , Tram Le Thi Hong , Kim Kyung Ah , Kim Byoung Choul 
Published: May 2023

AbstractCancer metastasis is affected by chemical factors and physical cues. From cell adhesion to migration, mechanical tension applied to integrin expresses on the cell membrane and physical confinement significantly regulates cancer cell behaviors. Despite the physical interplay between integrins in cells and ligands in the tumor microenvironment, quantitative analysis of integrin tension during cancer cell migration in microconfined spaces remains elusive owing to the limited experimental tools. Herein, a platform termed microconfinement tension gauge tether to monitor spatial integrin tension with single‐molecule precision by analyzing the epithelial‐growth‐factor‐induced chemotaxis of metastatic human breast cancer cells in microfluidic channels is developed. The results reveal that the metastatic cancer cells exert the strongest integrin tension in the range of 54–100 pN at the leading edges of cells during chemokinetic migration on a planar surface, while the cells exert the strongest integrin tension exceeding 100 pN at the cell rear when entering microconfinement. Further analysis demonstrates that cells undergo mesenchymal migration under high integrin tension and less confinement, which is converted to amoeboid migration under low integrin tension or high confinement. In summary, the results identify a basic mechanism underlying the mechanical interactions between integrin tension and microenvironment that determines cancer invasion and metastasis.