bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical Symptoms, Laboratory Parameters and Long-Term Follow-up in a National DADA2 Cohort
Authors: Andriessen Marie Valérie E. , Legger G. Elizabeth , Bredius Robbert G. M. , van Gijn Marielle E. , Hak A. Elisabeth , Muller Petra C. E. Hissink , Kamphuis Sylvia , Klouwer Femke C. C. , Kuijpers Taco W. , Leavis Helen L. , Nierkens Stefan , Rutgers Abraham , van der Veken Lars T. , van Well Gijs T. J. , Mulders-Manders Catharina M. , van Montfrans Joris M. 
Published: June 2023

AbstractDeficiency of adenosine deaminase-2 (DADA2) is an autosomal recessive autoinflammatory disease with an extremely variable disease presentation. This paper provides a comprehensive overview of the Dutch DADA2 cohort. We performed a retrospective cohort study in 29 ADA2-deficient patients from 23 families with a median age at inclusion of 26 years. All patients had biallelic pathogenic variants in the ADA2 gene. The most common clinical findings included cutaneous involvement (79.3%), (hepato)splenomegaly (70.8%) and recurrent infections (58.6%). Stroke was observed in 41.4% of the patients. The main laboratory abnormalities were hypogammaglobulinemia and various cytopenias. Patients presented most often with a mixed phenotype involving vasculopathy, immunodeficiency and hematologic manifestations (62.1%). In this cohort, malignancies were reported in eight patients (27.6%), of whom five presented with a hematologic malignancy and two with a basal cell carcinoma. Four patients developed hemophagocytic lymphohistiocytosis (HLH) or an HLH-like episode, of whom three passed away during or shortly after the occurrence of HLH. TNF-inhibitors (TNFi) were effective in treating vasculopathy-associated symptoms and preventing stroke, but were hardly effective in the treatment of hematologic manifestations. Three patients underwent hematopoietic cell transplantation and two of them are doing well with complete resolution of DADA2-related symptoms. The overall mortality in this cohort was 17.2%. In conclusion, this cohort describes the clinical, genetic and laboratory findings of 29 Dutch DADA2 patients. We describe the occurrence of HLH as a life-threatening disease complication and report a relatively high incidence of malignancies and mortality.
Approximating the Value of Zero-Sum Differential Games with Linear Payoffs and Dynamics
Authors: Kuipers Jeroen , Schoenmakers Gijs , Staňková Kateřina 
Published: June 2023

AbstractWe consider two-player zero-sum differential games of fixed duration, where the running payoff and the dynamics are both linear in the controls of the players. Such games have a value, which is determined by the unique viscosity solution of a Hamilton–Jacobi-type partial differential equation. Approximation schemes for computing the viscosity solution of Hamilton–Jacobi-type partial differential equations have been proposed that are valid in a more general setting, and such schemes can of course be applied to the problem at hand. However, such approximation schemes have a heavy computational burden. We introduce a discretized and probabilistic version of the differential game, which is straightforward to solve by backward induction, and prove that the solution of the discrete game converges to the viscosity solution of the partial differential equation, as the discretization becomes finer. The method removes part of the computational burden of existing approximation schemes.
Estimation of separable direct and indirect effects in a continuous-time illness-death model
Authors: Breum Marie Skov , Munch Anders , Gerds Thomas A. , Martinussen Torben 
Published: June 2023

AbstractIn this article we study the effect of a baseline exposure on a terminal time-to-event outcome either directly or mediated by the illness state of a continuous-time illness-death process with baseline covariates. We propose a definition of the corresponding direct and indirect effects using the concept of separable (interventionist) effects (Robins and Richardson in Causality and psychopathology: finding the determinants of disorders and their cures, Oxford University Press, 2011; Robins et al. in arXiv:2008.06019, 2021; Stensrud et al. in J Am Stat Assoc 117:175–183, 2022). Our proposal generalizes Martinussen and Stensrud (Biometrics 79:127–139, 2023) who consider similar causal estimands for disentangling the causal treatment effects on the event of interest and competing events in the standard continuous-time competing risk model. Unlike natural direct and indirect effects (Robins and Greenland in Epidemiology 3:143–155, 1992; Pearl in Proceedings of the seventeenth conference on uncertainty in artificial intelligence, Morgan Kaufmann, 2001) which are usually defined through manipulations of the mediator independently of the exposure (so-called cross-world interventions), separable direct and indirect effects are defined through interventions on different components of the exposure that exert their effects through distinct causal mechanisms. This approach allows us to define meaningful mediation targets even though the mediating event is truncated by the terminal event. We present the conditions for identifiability, which include some arguably restrictive structural assumptions on the treatment mechanism, and discuss when such assumptions are valid. The identifying functionals are used to construct plug-in estimators for the separable direct and indirect effects. We also present multiply robust and asymptotically efficient estimators based on the efficient influence functions. We verify the theoretical properties of the estimators in a simulation study, and we demonstrate the use of the estimators using data from a Danish registry study.
Modelling compound flooding: a case study from Jakarta, Indonesia
Authors: Bennett William G. , Karunarathna Harshinie , Xuan Yunqing , Kusuma Muhammad S. B. , Farid Mohammad , Kuntoro Arno A. , Rahayu Harkunti P. , Kombaitan Benedictus , Septiadi Deni , Kesuma Tri N. A. , Haigh Richard , Amaratunga Dilanthi 
Published: June 2023

AbstractThe paper investigates compound flooding from waves, sea surge and river flow in northern Jakarta, Indonesia, which is a global hotspot of flooding, by combining process-based coastal and river models. The coastal hydrodynamic modelling of Jakarta Bay in Indonesia shows that coastal storms can lead to a substantial increase in sea water level due to wind and wave setup in the nearshore areas, including Muara Angke river inlet. The compound flood hazard from a range of flood scenarios was simulated and analysed. The results reveal that low-lying areas around the river inlet are prone to flooding even during regular, low-intensity storm events, while rarer storms caused extensive floods. Floods were not caused by direct overwashing of sea defences but by overspill of the banks of the river inlet due to high sea water level caused by wind set up, wave setup, and sea surge obstructing the drainage of the river and elevating its water level during storms. We also found that the sea level rise combined with rapid land subsidence will inundate the existing coastal flood defences during storms in future. The majority of the city will be below mean sea level by 2100. The overflow of existing coastal defences will lead to extensive flooding in northern, western, and eastern Jakarta unless the defences are upgraded to keep up with future sea level rise.
Leadership and international collaboration on COVID-19 research: reducing the North–South divide?
Authors: Carvalho Danilo Silva , Felipe Lucas Lopes , Albuquerque Priscila Costa , Zicker Fabio , Fonseca Bruna de Paula 
Published: June 2023

AbstractThe COVID-19 pandemic triggered unprecedented scientific efforts worldwide and launched several initiatives to promote international cooperation. Because international scientific collaborations between high-income countries (HICs) and low- and middle-income countries (LMICs) are not always balanced, analyzing research leadership helps to understand the global dynamics of knowledge production during COVID-19. In this study, we focused on HIC–LMIC collaborations on COVID-19 research in 469,937 scientific publications during the first 2 years of the pandemic (2020–2021). Co-authorship and authors’ affiliation were used to identify international collaborations, according to country income level. The leadership analysis considered the countries of the first and last authors of publications. The results show that (i) most publications with international collaborations (49.3%) involved researchers from HICs and LMICs; (ii) collaborative research between HICs and LMICs addressed relevant public health needs; (iii) HIC–LMIC collaborations were primarily led by researchers from the United States, China, the United Kingdom, and India; (iv) most HIC–LMIC publications (44%) had shared leadership, with research interests linked to national expertise and global interests. This study contributes to the analysis of research collaborations on COVID-19 and sheds light on North–South relations in the production and dissemination of scientific knowledge.
Co-interaction of nitrofuran antibiotics and the saponin-rich extract on gram-negative bacteria and colon epithelial cells
Authors: Grzywaczyk Adam , Smułek Wojciech , Olejnik Anna , Guzik Urszula , Nowak Agnieszka , Kaczorek Ewa 
Published: June 2023

AbstractLarge-scale use of nitrofurans is associated with a number of risks related to a growing resistance to these compounds and the toxic effects following from their increasing presence in wastewater and the environment. The aim of the study was to investigate an impact of natural surfactant, saponins from Sapindus mukorossi, on antimicrobial properties of nitrofuran antibiotics. Measurements of bacterial metabolic activity indicated a synergistic bactericidal effect in samples with nitrofurantoin or furazolidone, to which saponins were added. Their addition led to more than 50% greater reduction in viable cells than in the samples without saponins. On the other hand, no toxic effect against human colon epithelial cell was observed. It was found that exposure to antibiotics and surfactants caused the cell membranes to be dominated by branched fatty acids. Moreover, the presence of saponins reduced the hydrophobicity of the cell surface making them almost completely hydrophilic. The results have confirmed a high affinity of saponins to the cells of Pseudomonas strains. Their beneficial synergistic effect on the action of antibiotics from the nitrofuran group was also demonstrated. This result opens promising prospects for the use of saponins from S. mukorossi as an adjuvant to reduce the emission of antibiotics into the environment.
A multimodal domestic service robot interaction system for people with declined abilities to express themselves
Authors: Qin Chaolong , Song Aiguo , Wei Linhu , Zhao Yu 
Published: June 2023

AbstractDriven by the shortage of qualified nurses and the increasing average age of the population, the ambient assisted living style using intelligent service robots and smart home systems has become an excellent choice to free up caregiver time and energy and provide users with a sense of independence. However, users’ unique environments and differences in abilities to express themselves through different interaction modalities make intention recognition and interaction between user and service system very difficult, limiting the use of these new nursing technologies. This paper presents a multimodal domestic service robot interaction system and proposes a multimodal fusion algorithm for intention recognition to deal with these problems. The impacts of short-term and long-term changes were taken into account. Implemented interaction modalities include touch, voice, myoelectricity gesture, visual gesture, and haptics. Users could freely choose one or more modalities through which to express themselves. Virtual games and virtual activities of independent living were designed for pre-training and evaluating users’ abilities to use different interaction modalities in their unique environments. A domestic service robot interaction system was built, on which a set of experiments were carried out to test the system’s stability and intention recognition ability in different scenarios. The experiment results show that the system is stable and effective and can adapt to different scenarios. In addition, the intention recognition rate in the experiments was 93.62%. Older adults could master the system quickly and use it to provide some assistance for their independent living.
Gesundheitsförderung und Prävention durch Gesundheitscoaches in der Routineversorgung – eine qualitative Interviewstudie mit Ärztinnen und Ärzten
Authors: Waibl Paula J. , Rothenhäusler Lena , Nöfer Eberhard , Meissner Karin 
Published: June 2023

Zusammenfassung
Hintergrund
Gesundheitsförderung und Prävention leisten wichtige Beiträge zur Vorbeugung von Krankheiten und Linderung von Krankheitsverläufen. Die Beratung von Patientinnen und Patienten zur Lebensführung erfordert Zeit, die in der medizinischen Routineversorgung häufig nicht ausreichend zur Verfügung steht. Einen möglichen Ansatzpunkt, um Maßnahmen der Prävention und Gesundheitsförderung stärker in die Routineversorgung zu integrieren, stellt die Einbindung eines Gesundheitscoaches dar. Die vorliegende qualitative Studie hatte zum Ziel, das Anforderungsprofil, den Bedarf und die Potenziale dieses noch nicht etablierten Berufsbilds aus ärztlicher Sicht zu untersuchen.

Methode
Mithilfe von halbstrukturierten, leitfadengestützten Interviews wurden 19 Ärztinnen und Ärzte aus dem stationären und ambulanten Setting zum möglichen Berufsbild des Gesundheitscoachs befragt. Die Interviews wurden aufgenommen, transkribiert und mittels qualitativer Inhaltsanalyse nach Mayring ausgewertet.

Ergebnisse
Die befragten Ärztinnen und Ärzte sprachen sich deutlich für den Einbezug von Gesundheitscoaches in die Routineversorgung von Patientinnen und Patienten aus. An das Berufsbild wurden verschiedene fachliche, persönliche, soziale, methodische und formale Anforderungen gestellt, die in einer akademisch fundierten Ausbildung vermittelt werden sollten. Die Potenziale eines Gesundheitscoachs wurden auf der Ebene der Patientinnen und Patienten, des Gesundheitssystems, der Kliniken und Praxen, der Ärztinnen und Ärzte und der zukünftigen Gesundheitscoaches selbst gesehen und reichten von besserer Gesundheitsförderung und verminderten Kosten bis hin zur Entlastung des ärztlichen Personals.

Schlussfolgerung
Der aus Sicht der Befragten vorhandene Bedarf an Gesundheitscoaches und die ermittelten Potenziale unterstreichen die Bedeutung der Integration dieses neuen Berufsbilds in die ärztliche Versorgung. Vor der Umsetzung sind weitere Studien notwendig, z. B. hinsichtlich der Finanzierbarkeit und des tatsächlichen Nutzens eines Gesundheitscoaches für Patientinnen und Patienten und für das Gesundheitssystem.
Retrospective analysis of operative time and time to discharge for laparoscopic vs robotic approaches to appendectomy and cholecystectomy
Authors: Rifai Ahmad Oussama , Rembetski Emily M. , Stutts Larry Collins , Mazurek Zachary D. , Yeh Jenifer L. , Rifai Kareem , Bear Ryan A. , Maquiera Alexander J. , Rydell David J. 
Published: June 2023

AbstractRobotic-assisted appendectomies and cholecystectomies are believed to increase cost compared to the gold standard laparoscopic approach. Two equally qualified surgeons performed both approaches over 2 years to evaluate intraoperative duration, time to discharge, conversion to open procedure, and readmission within 30 days. 110 laparoscopic, 81 robotic-assisted appendectomies; and 105 laparoscopic and 165 robotic-assisted cholecystectomies were performed. Intraoperative time; laparoscopic appendectomy was 1.402 vs 1.3615 h for robotic-assisted (P value = 0.304); laparoscopic cholecystectomy was 1.692 vs 1.634 h for robotic-assisted (P value = 0.196). Time to discharge, was 38.26 for laparoscopic vs 28.349 h for robotic-assisted appendectomy (P value = 0.010), and 35.95 for laparoscopic vs 28.46 h for robotic-assisted cholecystectomy (P value = 0.002). Intraoperative conversion to open; only laparoscopic procedures were converted, one appendectomy and nine cholecystectomies. None in the robotic-assisted procedures. Readmissions, none in the appendectomy group and three in the cholecystectomy group. One laparoscopic and two robotic-assisted cholecystectomy patients were readmitted. Intraoperative times for robotic appendectomy and cholecystectomy were not longer than laparoscopic approach. Robotic approach shortened the time to discharge and the likelihood for conversion to open procedure.
Assessment of Right Ventricular Function—a State of the Art
Authors: Hameed Abdul , Condliffe Robin , Swift Andrew J. , Alabed Samer , Kiely David G. , Charalampopoulos Athanasios 
Published: June 2023

Abstract
Purpose of Review
The right ventricle (RV) has a complex geometry and physiology which is distinct from the left. RV dysfunction and failure can be the aftermath of volume- and/or pressure-loading conditions, as well as myocardial and pericardial diseases.

Recent Findings
Echocardiography, magnetic resonance imaging and right heart catheterisation can assess RV function by using several qualitative and quantitative parameters. In pulmonary hypertension (PH) in particular, RV function can be impaired and is related to survival.

Summary
An accurate assessment of RV function is crucial for the early diagnosis and management of these patients. This review focuses on the different modalities and indices used for the evaluation of RV function with an emphasis on PH.
Pluripotent Stem Cell-derived Dopaminergic Neurons for Studying Developmental Neurotoxicity
Authors: Kreutz Anna , Hu Guang , Tokar Erik 
Published: June 2023

Abstract
With the vast number of chemicals in commerce, higher throughput strategies are needed to inform risk assessment. The field of toxicology is therefore moving away from traditional in vivo guideline studies towards in vitro new approach methodologies. There has been a great push for such a shift in the field of developmental neurotoxicity, where there is a particular lack of data. A battery of in vitro new approach methodologies has thus been developed to help fill this gap. Included in this battery are assays for numerous processes critical to neurodevelopment, such as proliferation, migration, and synaptogenesis. The current battery of developmental neurotoxicity new approach methodologies still lacks recapitulation of several critical neurodevelopmental processes, including development of neuronal subtypes. With their pluripotency, alongside other advantages, pluripotent stem cells (PSCs) are uniquely suited to address questions of developmental neurotoxicity, as they can recapitulate the different stages of human in vivo neurodevelopment. Among the various neuronal subtypes, development of dopaminergic neurons (DA) is perhaps the best understood and several approaches exist to differentiate PSCs into DA. Herein we review these approaches and propose utilizing PSCs for screening of the impact of environmental chemicals on development of DA. Related techniques and gaps in knowledge are also addressed.
Graphical Abstract
Socio-economic status moderates the relationship between values and subjective well-being among Chinese college students
Authors: Lan Lili , Wang Xiaofeng 
Published: June 2023

AbstractPersonal values and socioeconomic status (SES) both influence adolescents’ subjective well-being, yet there is still a need to explore whether differences in values and SES have different impacts on one’s subjective well-being (SWB). This study examined the moderation effect of SES in the relationship between two values (self-improvement and collective responsibility) and SBW. A sample comprising 600 Chinese college students (23.40% boys, mean age = 21.21, SD = 1.56) were measured twice over the course of one year using the Chinese Adolescent Values Questionnaire and the Subjective Well-Being Questionnaire. Results showed that self-improvement value may promote SWB of students with a low SES, but this result was not seen in the students with a high SES. Meanwhile, collective responsibility value may promote SWB in students with a low SES, while it may reduce SWB in students with a high SES. Our findings suggested that self-improvement and collective responsibility values can help low SES students access resources and support, helping them overcome unfavorable situations. However, a different picture was shown for students with a high SES. In contrast to the low-SES students, these two values seemed to restrict the growth of students with a high SES, hampering their pursuit of their own goals and interests, which may ultimately diminish their SWB.
Wer leidet in der Sozialen Arbeit an Erschöpfung?
Authors: Hollederer Alfons 
Published: June 2023

ZusammenfassungNach der internationalen Studienlage weisen Sozialarbeitende ein hohes berufsspezifisches Risiko für die Entwicklung von Disstress, Erschöpfung und Burnout auf. Gemäß dem Modell der Arbeitsanforderungen und -ressourcen (JD-R) führen hohe oder schlechte Arbeitsanforderungen zu Erschöpfung. In Deutschland besteht ein Forschungsdefizit zur Gesundheit von Sozialarbeitenden. Ziel der Untersuchung ist es, innerhalb der Sozialen Arbeit gefährdete Personengruppen unter Berücksichtigung von berufsspezifischen Einflussfaktoren zu identifizieren. Datenbasis der Sekundäranalyse ist die repräsentative BIBB/BAuA-Erwerbstätigenbefragung 2018, die als eine randomisierte Stichprobe der Erwerbsbevölkerung in Deutschland gezogen wurde. 341 der 20.012 Befragten übten zum Erhebungszeitpunkt eine berufliche Tätigkeit als Sozialarbeitende aus. Von den Sozialarbeitenden berichteten 25 % ein häufiges Auftreten sowohl einer emotionalen Erschöpfung als auch einer körperlichen Erschöpfung in den letzten 12 Monaten während der Arbeit. Der Anteil übertrifft signifikant den Durchschnittswert von 17 % bei den anderen Berufen. Logistische Regressionsanalysen zielten innerhalb der Sozialarbeitenden auf das Auftreten von emotionaler und körperlicher Erschöpfung in den letzten 12 Monaten. In die multivariate Betrachtung wurden soziodemografische Merkmale sowie Arbeitsanforderungen und -ressourcen als Prädiktoren einbezogen. Als stärkste Prädiktorvariable stellte sich die häufige emotionale Arbeitsanforderung heraus. Bei Sozialarbeitenden, die sich berufsbedingt gehäuft in emotional belastenden Situationen befanden, ist die Wahrscheinlichkeit emotionaler und körperlicher Erschöpfung um mehr als das Dreifache gesteigert (OR = 3,19). Als sehr wichtiger Protektivfaktor wird die häufige Vereinbarkeit von Arbeitszeitplanung und Familie identifiziert (OR = 0,34). Dagegen steigerte eine höhere Arbeitsintensität die Wahrscheinlichkeit des Vorkommens emotionaler und körperlicher Erschöpfung signifikant (OR = 1,39). Die Sekundäranalyse der BIBB/BAuA-Erwerbstätigenbefragung 2018 ergibt bei den Sozialarbeitenden ambivalente Resultate zu Arbeitsressourcen sowie berufsspezifischen Risiken und zeigt Präventionspotenzial auf.