bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of exercise on chronic neck pain and central sensitization: A protocol for a randomized crossover trial
Authors: Chen Kexun Kenneth , Hutchinson Mark Rowland , Rolan Paul , de Zoete Rutger Marinus Johannes 
Published: March 2023

AbstractExercise‐induced hypoalgesia (EIH) has been found to vary widely within individuals with chronic neck pain (NP). Research has suggested that the presence of central sensitization within a subgroup of individuals with chronic NP might be a mediating factor to explain the relationship between exercise and improvements in patient‐reported outcomes. Furthermore, recent work has found that lactate might play a role in the development and maintenance of chronic pain. The immediate effect of a single bout of physical exercise on central sensitization in individuals with chronic NP and the relationship between lactate concentration, central sensitization and pain sensitivity are to be investigated. Eighty adult participants with chronic NP will be recruited for this randomized crossover trial. Outcome measures, including temporal summation, conditioned pain modulation, EIH and lactate concentration, will be assessed before and after low‐ and high‐intensity bicycling exercise. The outcomes of this study will provide new insights into the mechanistic effect of exercise on central sensitization in individuals with chronic NP and have the potential to add important information to the current exercise prescription guidelines for individuals with chronic NP. This study has been approved by the Human Research Ethics Committee, The University of Adelaide (H‐2022‐082) and registered in the Australian New Zealand Clinical Trials Registry (ACTRN12622000642785p).
Quantification of Ureteral Pain Sensation Induced by Kidney Stone
Authors: Liu Yonggang , Liu Shaobao , Li Moxiao , Lu Tian Jian 
Published: March 2023

Abstract
Pain sensation induced by kidney stone (renal calculi) in ureter, a kind of visceral ducts connecting the kidneys and bladder, critically depends upon the relative size of stone to ureter. To quantify such pain sensation, we draw a parallel analogy between the mechanisms underlying skin pain (which can be quantified with a holistic pain model consisting of a modified Hodgkin–Huxley model and gate control theory) and mechanism of ureteral pain to extend the holistic pain model to the stone-blocked ureter. We then perform finite element simulations to obtain key mechanical stresses on the ureter wall exerted by a kidney stone having varying sizes. These stresses are subsequently adopted to calculate the voltage potential of neuron membrane in the holistic pain model and eventually a theoretical framework to quantify the dependence of ureteral pain sensation on stone size is established, for the first time. We demonstrate that ureter pain sensation increases sharply when the diameter of the kidney stone becomes 7.5% to 20% larger than the inner diameter of ureter, peaking at ∼20% larger; however, increasing further the stone diameter leads only to marginally exacerbated pain sensation. Other related effects on ureter pain sensation, such as ureter wall thickness, ureter stiffness, and intra-abdominal pressure (IAP), are evaluated. The results of the present study provide insightful information for urologists to diagnose and treat patients with renal calculi in a more personalized way.
Leveraging Dynamics-Induced Snap-Through Instabilities to Access Giant Deformations in Dielectric Elastomer Membranes
Authors: Cooley Christopher G. , Lowe Robert L. 
Published: March 2023

AbstractAchieving extreme deformations without electrical breakdown has been a longstanding challenge in the dielectric elastomer community. In this paper, we present a novel approach for accessing giant in-plane stretches in circular dielectric elastomer membranes by leveraging nonlinear dynamics, specifically short-duration voltage pulses. These voltage pulses—applied about nominal bias voltages where the large-stretch equilibrium does not experience dielectric breakdown—create transient stretches that, if sufficiently large, cause the membrane to dynamically snap-through to its large-stretch equilibrium. These giant deformations are reversible; pulsed voltage drops can return the membrane from its large-stretch equilibrium to its small-stretch equilibrium. Parametric analyses are used to determine the combinations of pulse amplitude and duration that result in snap-through. Corresponding through-thickness electric fields are shown to be below stretch-dependent dielectric strengths from the literature, suggesting practical feasibility. Unlike other techniques for accessing extreme stretches in dielectric elastomers, the present approach relies on voltage control alone; it therefore does not require altering the external mechanical forces that cause pre-stretch and can be applied without modifying the elastomer’s mechanical compliance. This research demonstrates that carefully designed voltage pulses may permit existing and emerging soft material technologies to access extreme, large-stretch equilibria without dielectric breakdown.
A Comparison Study of Human and Machine-Generated Creativity
Authors: Chen Liuqing , Sun Lingyun , Han Ji 
Published: March 2023

Abstract
Creativity is a fundamental feature of human intelligence. However, achieving creativity is often considered a challenging task, particularly in design. In recent years, using computational machines to support people in creative activities in design, such as idea generation and evaluation, has become a popular research topic. Although there exist many creativity support tools, few of them could produce creative solutions in a direct manner, but produce stimuli instead. DALL·E is currently the most advanced computational model that could generate creative ideas in pictorial formats based on textual descriptions. This study conducts a Turing test, a computational test, and an expert test to evaluate DALL·E’s capability in achieving combinational creativity comparing with human designers. The results reveal that DALL·E could achieve combinational creativity at a similar level to novice designers and indicate the differences between computer and human creativity.
Caught in the act: Diamond growth and destruction in the continental lithosphere
Authors: Howarth Geoffrey H. , Kahle Beth , Janney Philip E. , Kahle Richard , Du Plessis Anton , Richardson Stephen H. , Gurney John J. 
Published: March 2023

Abstract
Diamonds can form within eclogite (remnants of ancient subducted oceanic crust) in the subcontinental lithospheric mantle (SCLM), pieces of which may then be transported to the surface as xenoliths in kimberlites. These diamond-bearing xenoliths offer a rare opportunity to study diamonds in their host lithology. The morphology and surface features of diamonds record evidence of attack by diamond-aggressive melts/fluids, which results in resorption, rounding, and destruction of octahedral growth forms. The location and timing of such diamond-destruction processes remain controversial, and the kimberlite magma itself is often considered to be the primary culprit. We used X-ray computed tomography scanning to present a view of diamond morphology and distribution within 24 diamondiferous eclogites in unprecedented detail. These scans clearly capture diamond growth and destruction that occurred within the SCLM, prior to kimberlite entrainment. We show that euhedral diamonds in these eclogites are predominantly step-faced octahedra. This morphology is preserved even when the diamonds are exposed at the surface of the eclogites, indicating that kimberliteinduced resorption was not significant. Six eclogites contain only rounded diamonds with no distinct crystal faces, and their exposed surfaces on the exterior of the xenoliths are highly irregular, indicating diamond-destruction in the SCLM. In three cases, single xenoliths host both resorbed diamonds and step-faced octahedra, indicating multiple metasomatic events, some of which were diamond-aggressive and others diamond-friendly. These diamondiferous xenoliths provide snapshots of diamond growth and destruction in the SCLM, caught in the act.
Preferences about place of end-of-life care and death of patients with life-threatening illnesses and their families: a protocol for an umbrella review
Authors: Pinto Sara , Lopes Silvia , Bruno de Sousa Andrea , Gomes Barbara 
Published: March 2023

IntroductionFor most of history, the majority of people died at home surrounded by family. However, the global scenario has progressively changed towards hospital death and more recently in some countries back again towards home, with indication that COVID-19 may have further increased the number of home deaths. It is therefore timely to establish the state-of-the-art about people’s preferences for place of end-of-life care and death, to understand the full spectrum of preferences, nuances and commonalities worldwide. This protocol describes the methods for an umbrella review which aims to examine and synthesise the available evidence regarding preferences about place of end-of-life care and death of patients with life-threatening illnesses and their families.Methods and analysisWe will search for relevant systematic reviews (quantitative and/or qualitative) in six databases from inception without language restrictions: PsycINFO, MEDLINE, EMBASE, CINAHL, PROSPERO and Epistemonikos. Following the Joanna Briggs Institute (JBI) methodology for umbrella reviews, eligibility screening, data extraction and quality assessment (using the JBI Critical Appraisal Checklist) will be done by two independent reviewers. We will report the screening process using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses flow diagram. Study double-counting will be reported using the Graphical Representation of Overlap for OVErviews tool. A narrative synthesis will include ‘Summary of Evidence’ tables to address five review questions (distribution of preferences and reasons, influencing variables, place of care vs place of death, changes over time, congruence between preferred and actual places), grading the evidence on each question using Grading of Recommendations Assessment, Development and Evaluation (GRADE) and/or GRADE-Confidence in the Evidence from Reviews of Qualitative research.Ethics and disseminationThis review does not require ethical approval. The results will be presented at conferences and published in a peer-reviewed journal.PROSPERO registration numberCRD42022339983.
Is spatial exposure to heritage associated with visits to heritage and to mental health? A cross-sectional study using data from the UK Household Longitudinal Study (UKHLS)
Authors: Macdonald Laura , Nicholls Natalie , Gallou Eirini , Monckton Linda , Mitchell Richard 
Published: March 2023

ObjectivesExisting research highlights the beneficial nature of heritage engagement for mental health, but engagement varies geographically and socially, and few studies explore spatial exposure (ie, geographic availability) to heritage and heritage visits. Our research questions were ‘does spatial exposure to heritage vary by area income deprivation?’, ‘is spatial exposure to heritage linked to visiting heritage?’ and ‘is spatial exposure to heritage linked to mental health?’. Additionally, we explored whether local heritage is associated with mental health regardless of the presence of green space.DesignData were collected from January 2014 to June 2015 via the UK Household Longitudinal Study (UKHLS) wave 5. Our study is cross-sectional.SettingUKHLS data were either collected via face-to-face interview or online questionnaire.Participants30 431 adults (16+ years) (13 676 males, 16 755 females). Participants geocoded to Lower Super Output Area (LSOA) ‘neighbourhood’ and ‘English Index of Multiple Deprivation’ 2015 income score.Main exposures/outcome measuresLSOA-level heritage exposure and green space exposure (ie, population and area densities); heritage site visit in the past year (outcome, binary: no, yes); mental distress (outcome, General Health Questionnaire-12, binary: less distressed 0–3, more distressed 4+).ResultsHeritage varied by deprivation, the most deprived areas (income quintile (Q)1: 1.8) had fewer sites per 1000 population than the least deprived (Q5: 11.1) (p<0.01). Compared with those with no LSOA-level heritage, those with heritage exposure were more likely to have visited a heritage site in the past year (OR: 1.12 (95% CI 1.03 to 1.22)) (p<0.01). Among those with heritage exposure, visitors to heritage had a lower predicted probability of distress (0.171 (95% CI 0.162 to 0.179)) than non-visitors (0.238 (95% CI 0.225 to 0.252)) (p<0.001).ConclusionsOur research contributes to evidence for the well-being benefits of heritage and is highly relevant to the government’s levelling-up heritage strategy. Our findings can feed into schemes to tackle inequality in heritage exposure to improve both heritage engagement and mental health.
Identification of HPV16 E1 and E2-specific T cells in the oropharyngeal cancer tumor microenvironment
Authors: McInnis Christine , Bhatia Shilpa , Vijaykumar Brinda , Tian Qiaomu , Sun Yanbo , Leistritz-Edwards Del , Quinn Charles T , Uppaluri Ravi , Egloff Ann Marie , Srinivasan Lakshmi , Pregibon Daniel C , Coyle Anthony J , Hanna Glenn J 
Published: March 2023

BackgroundHigh-risk human papillomavirus (HPV) is a primary cause of an increasing number of oropharyngeal squamous cell carcinomas (OPSCCs). The viral etiology of these cancers provides the opportunity for antigen-directed therapies that are restricted in scope compared with cancers without viral components. However, specific virally-encoded epitopes and their corresponding immune responses are not fully defined.MethodsTo understand the OPSCC immune landscape, we conducted a comprehensive single-cell analysis of HPV16+ and HPV33+ primary tumors and metastatic lymph nodes. We used single-cell analysis with encoded peptide-human leukocyte antigen (HLA) tetramers to analyze HPV16+ and HPV33+ OPSCC tumors, characterizing the ex vivo cellular responses to HPV-derived antigens presented in major Class I and Class II HLA alleles.ResultsWe identified robust cytotoxic T-cell responses to HPV16 proteins E1 and E2 that were shared across multiple patients, particularly in HLA-A*01:01 and HLA-B*08:01. Responses to E2 were associated with loss of E2 expression in at least one tumor, indicating the functional capacity of these E2-recognizing T cells and many of these interactions validated in a functional assay. Conversely, cellular responses to E6 and E7 were limited in quantity and cytotoxic capacity, and tumor E6 and E7 expression persisted.ConclusionsThese data highlight antigenicity beyond HPV16 E6 and E7 and nominate candidates for antigen-directed therapies.
Effect of intravenous thrombolysis before endovascular therapy on outcomes in patients with large core infarct
Authors: Anadani Mohammad , Almallouhi Eyad , Maier Ilko , Al Kasab Sami , Jabbour Pascal , Kim Joon-tae , Wolfe Stacey Q , Rai Ansaar , Starke Robert M , Psychogios Marios-Nikos , Samaniego Edgar A , Arthur Adam S , Yoshimura Shinichi , Cuellar Hugo , Howard Brian M , Alawieh Ali , Fragata Isabel , Polifka Adam J , Mascitelli Justin R , Osbun Joshua W , Matouk Charles , Park Min S , Levitt Michael R , Dumont Travis M , Williamson Richard , Spiotta Alejandro M 
Published: March 2023

BackgroundThe safety and efficacy of bridging therapy with intravenous thrombolysis (IVT) and mechanical thrombectomy (MT) in patients with large core infarct has not been sufficiently studied. In this study, we compared the efficacy and safety outcomes between patients who received IVT+MT and those treated with MT alone.MethodsThis is a retrospective analysis of the Stroke Thrombectomy Aneurysm Registry (STAR). Patients with Alberta Stroke Program Early CT Score (ASPECTS) ≤5 treated with MT were included in this study. Patients were divided into two groups based on pre-treatment IVT (IVT, no IVT). Propensity score matched analysis were used to compare outcomes between groups.ResultsA total of 398 patients were included; 113 pairs were generated using propensity score matching analyses. Baseline characteristics were well balanced in the matched cohort. The rate of any intracerebral hemorrhage (ICH) was similar between groups in both the full cohort (41.4% vs 42.3%, P=0.85) and matched cohort (38.55% vs 42.1%, P=0.593). Similarly, the rate of significant ICH was similar between the groups (full cohort: 13.1% vs 16.9%, P=0.306; matched cohort: 15.6% vs 18.95, P=0.52). There was no difference in favorable outcome (90-day modified Rankin Scale 0–2) or successful reperfusion between groups. In an adjusted analysis, IVT was not associated with any of the outcomes.ConclusionPretreatment IVT was not associated with an increased risk of hemorrhage in patients with large core infarct treated with MT. Future studies are needed to assess the safety and efficacy of bridging therapy in patients with large core infarct.
High-grade and low-grade HPV-induced urethral lesions treated by CO2laser under colposcopy
Authors: Aynaud Olivier , Huynh Bernard , Bergeron Christine 
Published: March 2023

ObjectivesThis study is reporting the CO2laser treatment efficiency on urethral lesions caused by human papillomavirus (HPV) and the correlation between the type of lesion high-grade and low-grade on the histology and the HPV genotype(s).MethodsSixty-nine patients (59 men and 10 women) with urethral lesions were screened for HPV genotype(s) by in situ hybridisation and PCR. HPV lesions were biopsied and p16INK4aexpression was tested to confirm urethral high-grade squamous intraepithelial lesions (U HSIL) on the histology prior to CO2laser treatment under colposcopy. The patients were followed up for 12 months.ResultsWe observed urethral low-grade squamous intraepithelial lesions (U LSIL) in 54/69 cases (78.3%) and U HSIL in 7/69 cases (10%) confirmed by p16INK4a staining. Then we looked at the HPV genotype present in each lesion. We observed the following: 31/69 (45%) patients have a unique HPV genotype, with 12/31 (38.7%) of high risk; 21/54 (38.8%) of U LSIL and 1/7 (14%) of U HSIL have HPV low-risk and high-risk coinfections. Efficient treatment with CO2laser under colposcopy was done using a meatal spreader to help visualisation of 20 mm in the distal urethra. We cured 64/69 (92.7%) patients at 3 months with 4/69 (5.7%) meatotomy and persistent 1/67 (1.4%) urethral stricture at 12 months.ConclusionsHSIL was present in the urethra without being able to define specific clinical criteria. Treatment with a CO2laser under colposcopy with a meatus spreader is a simple surgical procedure with high efficiency and few complications that could prevent the risk of HPV-induced carcinoma.
Self-sampling strategies (with/without digital innovations) in populations at risk ofChlamydia trachomatisandNeisseria gonorrhoeae: a systematic review and meta-analyses
Authors: Vialard Fiorella , Anand Apoorva , Leung Soo Cindy , de Waal Anna , McGuire Madison , Carmona Sergio , Fernández-Suárez Marta , Zwerling Alice Anne , Pant Pai Nitika 
Published: March 2023

BackgroundChlamydia trachomatis(CT) andNeisseria gonorrhoeae(GC) resulted in over 200 million new sexually transmitted infections last year. Self-sampling strategies alone or combined with digital innovations (ie, online, mobile or computing technologies supporting self-sampling) could improve screening methods. Evidence on all outcomes has not yet been synthesised, so we conducted a systematic review and meta-analysis to address this limitation.MethodsWe searched three databases (period: 1 January 2000–6 January 2023) for reports on self-sampling for CT/GC testing. Outcomes considered for inclusion were: accuracy, feasibility, patient-centred and impact (ie, changes in linkage to care, first-time testers, uptake, turnaround time or referrals attributable to self-sampling).We used bivariate regression models to meta-analyse accuracy measures from self-sampled CT/GC tests and obtain pooled sensitivity/specificity estimates. We assessed quality with Cochrane Risk of Bias Tool-2, Newcastle–Ottawa Scale and Quality Assessment of Diagnostic Accuracy Studies-2 tool.ResultsWe summarised results from 45 studies reporting self-sampling alone (73.3%; 33 of 45) or combined with digital innovations (26.7%; 12 of 45) conducted in 10 high-income (HICs; n=34) and 8 low/middle-income countries (LMICs; n=11). 95.6% (43 of 45) were observational, while 4.4% (2 of 45) were randomised clinical trials.We noted that pooled sensitivity (n=13) for CT/GC was higher in extragenital self-sampling (>91.6% (86.0%–95.1%)) than in vaginal self-sampling (79.6% (62.1%–90.3%)), while pooled specificity remained high (>99.0% (98.2%–99.5%)).Participants found self-sampling highly acceptable (80.0%–100.0%; n=24), but preference varied (23.1%–83.0%; n=16).Self-sampling reached 51.0%–70.0% (n=3) of first-time testers and resulted in 89.0%–100.0% (n=3) linkages to care. Digital innovations led to 65.0%–92% engagement and 43.8%–57.1% kit return rates (n=3).Quality of studies varied.DiscussionSelf-sampling had mixed sensitivity, reached first-time testers and was accepted with high linkages to care. We recommend self-sampling for CT/GC in HICs but additional evaluations in LMICs. Digital innovations impacted engagement and may reduce disease burden in hard-to-reach populations.PROSPERO registration numberCRD42021262950.
Crowding-out effect of tobacco consumption in Serbia
Authors: Vladisavljevic Marko , Zubović Jovan , Jovanovic Olivera , Đukić Mihailo 
Published: March 2023

BackgroundAlthough smoking prevalence and intensity in Serbia have decreased in recent years, expenditures on tobacco products still represent a significant portion of household budgets. As households have limited resources at their disposal, consuming tobacco means that they spend less on other items such as food, clothing, education and healthcare. This is particularly true for low-income households, for whom the pressure on the household budget is even higher.ObjectivesIn this research we estimate the effect of tobacco consumption on other consumption items in Serbia, which is the first estimation of this type for the countries in Eastern Europe.MethodsWe use microdata from the Household Budget Survey and estimation approach that includes the combination of seemingly unrelated regression and instrumental variables. Besides estimating the overall effect we analyse the differences in effects between low-income, medium-income and high-income households.ResultsExpenditures on tobacco reduce consumption on food, clothing and education and increase the budget shares spent on complementary consumption items such as alcohol, hotels, bars and restaurants. In most cases, the effects are more pronounced for low-income households than for other groups. These results suggest that aside from the negative effects of tobacco consumption on health, it also distorts household consumption structure, while affecting intrahousehold allocation and future health and development of other household members.ConclusionsThe results from this research underline the negative effect that tobacco expenditures have on consumption of other products. The only way for households to decrease expenditures on tobacco is to stop smoking, as the consumption of those who continue smoking changes less than cigarettes prices. To ensure that households stop smoking and instead direct their expenditures towards more productive purposes, the Serbian government should adopt new policies and strengthen enforcement of existing tobacco control measures.