bluuebunny/crossref_metadata_2025_split huggingface dataset:
An updated profile of the bovine acute phase response following an intravenous lipopolysaccharide challenge
Authors: Smock Taylor M , Rand Broadway P , Burdick Sanchez Nicole C , Carroll Jeffery A , Theurer Miles E , Hales Kristin E 
Published: April 2023

Abstract
The objective was to provide an updated profile of the bovine acute-phase response to include recent advancements in technologies and expanded hematological, cytokine, and serum chemistry variables. Beef steers (n = 32; body weight [BW] = 251 ± 19.5 kg) were fitted with indwelling jugular catheters 1 d before lipopolysaccharide (LPS; 0.25 µg LPS/kg BW from Escherichia coli O111:B4) administration to facilitate serial blood collection. Rectal temperature was measured using indwelling probes, and ocular temperature was measured using infrared thermal imaging. Blood samples were collected for subsequent analysis of serum chemistry, hematology, and cytokine concentrations. Pearson correlation of rectal temperature and ocular infrared temperature was 0.61 (P &lt; 0.01) and the Spearman correlation coefficient was 0.56 (P &lt; 0.01). Interactions of hour × method were observed for ocular and rectal measurements of body temperature in response to endotoxin exposure. Maximum observed temperature was 39.6 °C at 2.5 h for both rectal and ocular measurements. Body temperature differed by method at hours 0.5, 2.5, 4.5, 7.5, 12.5, 36.5, and 47.5 (P &lt; 0.01), but were not different otherwise. All variables of serum chemistry and complete blood count were influenced by LPS administration, except creatinine, serum glucose, and percent basophils (P ≤ 0.02). Alanine aminotransferase and alkaline phosphatase peaked at hour 2 relative to LPS administration, returned to baseline at hour 12 and continued to decrease below the baseline value at hour 48 (P &lt; 0.01). Total protein concentration decreased 3% in response to LPS (P = 0.01). Total white blood cell count decreased 75% after LPS administration at hour 1 (P &lt; 0.01). Lymphocyte count recovered to baseline at hour 6; sooner than neutrophil count at hour 36. Serum cortisol concentration increased 294% relative to baseline at hour 1 followed by a sustained decrease and return to normal concentration at hour 4 (P &lt; 0.01). Additionally, circulating cytokine concentrations changed with time in response to the LPS challenge, excluding aFGF, bFGF, IGF-1, IL-2, IL-4, MCP-1, and ANG-1 (P ≤ 0.08). Maximum observed concentration of TNF-α at hour 1 was 117% greater than the pre-challenge value (P &lt; 0.01). Data presented herein add to existing works to understand the endocrine and immune responses of beef steers administered exogenous LPS, and incorporate recent technologies, additional biomarkers, and an expanded cytokine profile that can be used as referential data in future research.
The EU’s International Relations in the Practice of Criticizing the Human Rights Record of Russia
Authors: Jusufi Islam 
Published: April 2023

Abstract
The European Union’s international relations are organized into a series of practices that regulate its relationships with the third states, including with Russia. The primary practice is that of ‘criticizing’ the human rights record of Russia, and this represents a major part of the EU’s engagement with Russia. This article analyses the practice of EU criticism of Russia regarding its implementation of human rights norms and values as a case which helps define the role of human rights in EU-Russia relations. It proposes that the EU’s transformative power over Russia has been minimal. It further argues that the success of the practice of criticizing human rights records has been limited to the institutionalization of EU-Russia cooperation in this area.
Algebraic logic for the negation fragment of classical logic
Authors: González Luciano J 
Published: April 2023

Abstract
The general aim of this article is to study the negation fragment of classical logic within the framework of contemporary (Abstract) Algebraic Logic. More precisely, we shall find the three classes of algebras that are canonically associated with a logic in Algebraic Logic, i.e. we find the classes $\textrm{Alg}^*$, $\textrm{Alg}$ and the intrinsic variety of the negation fragment of classical logic. In order to achieve this, firstly, we propose a Hilbert-style axiomatization for this fragment. Then, we characterize the reduced matrix models and the full generalized matrix models of this logic. Also, we classify the negation fragment in the Leibniz and Frege hierarchies.
Carbon monoxide ices – a semicentennial review and update for crystalline CO along with the first IR spectrum and band strength for amorphous CO
Authors: Gerakines Perry A , Materese Christopher K , Hudson Reggie L 
Published: April 2023

ABSTRACT
The intrinsic intensity (band strength) of the fundamental vibrational band of crystalline carbon monoxide (CO) was first determined 50 yr ago, but those pioneering measurements have seldom been revisited despite CO's importance in interstellar and Solar System chemistry and CO's abundance and distribution in extraterrestrial environments. On the semicentennial of those first measurements, which remain in wide use among observational and laboratory astrochemists, we have reexamined those infrared (IR) band-strength determinations, including the density and refractive index data on which they rest, and find that the published results rest on a mere two data points. Here we use new laboratory data to identify and address errors and concerns in that original work from a half-century ago, plus a result from nearly 100 yr ago. We report new IR intensities for crystalline CO's fundamental IR band over a range of temperatures and resolutions for the first time, finding that there is not a single unique band strength that applies to all conditions. Optical constants have been calculated, including a set at a higher resolution than in the literature. We also present the first direct IR intensity measurements of the fundamentals of solid 13C16O, 12C17O, and 12C18O. Finally, the first IR transmission spectrum of amorphous CO is presented along with a band-strength estimate. All results are for temperatures below 30 K, and so are relevant to studies of solid CO in the outer Solar System and the interstellar medium.
VLBI Astrometry of radio stars to link radio and optical celestial reference frames. I. HD 199178 & AR Lacertae
Authors: Chen Wen , Zhang Bo , Zhang Jingdong , Yang Jun , Xu Shuangjing , Sun Yan , Mai Xiaofeng , Shu Fengchun , Wang Min 
Published: April 2023

ABSTRACT
To accurately link the radio and optical Celestial Reference Frames (CRFs) at optical bright end, i.e. with GaiaG-band magnitude $\lesssim$13, increasing number and improving sky distribution of radio stars with accurate astrometric parameters from both Very Long Baseline Interferometry (VLBI) and Gaia measurements are mandatory. We selected two radio stars HD 199178 and AR Lacertae as the target for a pilot program for the frame link, using the Very Long Baseline Array at 15 GHz at six epochs spanning about 1 yr, to measure their astrometric parameters. The measured parallax of HD 199178 is 8.949 ± 0.059 mas and the proper motion is μαcos δ = 26.393 ± 0.093 and μδ = −0.950 ± 0.083 mas yr−1, while the parallax of AR Lac is 23.459 ± 0.094 mas and the proper motion is μαcos δ = −51.906 ± 0.138 and μδ = 46.732 ± 0.131 mas yr−1. Our VLBI measured astrometric parameters have accuracies about 4–5 times better than the corresponding historic VLBI measurements and comparable accuracies with those from Gaia, validating the feasibility of frame link using radio stars. With the updated astrometric parameters for these two stars, there is a ∼25 per cent reduction of the uncertainties on the Y-axis for both orientation and spin parameters.
On the evolution of the size of Lyman alpha haloes across cosmic time: no change in the circumgalactic gas distribution when probed by line emission
Authors: Runnholm Axel , Hayes Matthew J , Lin Yu-Heng , Melinder Jens , Scarlata Claudia , Adamo Angela , Augustin Ramona , Bik Arjan , Blaizot Jérémy , Cannon John M , Cantalupo Sebastiano , Garel Thibault , Gronke Max , Herenz Edmund C , Leclercq Floriane , Östlin Göran , Peroux Celine , Rasekh Armin , Rutkowski Michael J , Verhamme Anne , Wisotzki Lutz 
Published: April 2023

ABSTRACT
Lyman α (Lyα) is now routinely used as a tool for studying high-redshift galaxies, and its resonant nature means it can trace neutral hydrogen around star-forming galaxies. Integral field spectrograph measurements of high-redshift Lyα emitters indicate that significant extended Lyα halo emission is ubiquitous around such objects. We present a sample of redshift 0.23 to 0.31 galaxies observed with the Hubble Space Telescope selected to match the star formation properties of high-z samples while optimizing the observations for detection of low surface brightness Lyα emission. The Lyα escape fractions range between 0.7 and 37 per cent, and we detect extended Lyα emission around six out of seven targets. We find Lyα halo to UV scale length ratios around 6:1, which is marginally lower than high-redshift observations, and halo flux fractions between 60 and 85 per cent – consistent with high-redshift observations – when using comparable methods. However, our targets show additional extended stellar UV emission: we parametrize this with a new double exponential model. We find that this parametrization does not strongly affect the observed Lyα halo fractions. We find that deeper Hα data would be required to firmly determine the origin of Lyα halo emission; however, there are indications that Hα is more extended than the central FUV profile, potentially indicating conditions favourable for the escape of ionizing radiation. We discuss our results in the context of high-redshift galaxies, cosmological simulations, evolutionary studies of the circumgalactic medium in emission, and the emission of ionizing radiation.
Two Forms of Sexual Dimorphism in Gene Expression inDrosophila melanogaster: Their Coincidence and Evolutionary Genetics
Authors: Singh Amardeep , Agrawal Aneil F 
Published: April 2023

AbstractPhenotypic sexual dimorphism can be mediated by sex differences in gene expression. We examine two forms of sexual dimorphism in gene expression in Drosophila melanogaster: 1) sex-biased gene expression (SBGE) in which the sexes differ in the amount a gene is expressed and 2) sexual dimorphism in isoform usage, that is, sex-specific splicing (SSS). In whole body (but not the head) expression, we find a negative association between SBGE and SSS, possibly suggesting that these are alternate routes to resolving sexual antagonistic selection. Next, we evaluate whether expression dimorphism contributes to the heterogeneity among genes in rmf, the intersexual genetic correlation in body expression that constrains the extent to which a gene's expression can evolve independently between the sexes. We find lower rmf values for genes with than without SSS. We find higher rmf values for male- than female-biased genes (except genes with extreme male bias), even though male-biased genes are known to have greater evolutionary divergence in expression. Finally, we examine population genetic patterns in relation to SBGE and SSS because genes with expression dimorphism have likely experienced a history of sex differences in selection. SSS is associated with reduced values of Tajima's D and elevated direction of selection (DoS) values, suggestive of higher rates of adaptive evolution. Though DoS is highly elevated for genes with extreme male bias, DoS otherwise tends to decline from female-biased to unbiased to male-biased genes. Collectively, the results indicate that SBGE and SSS are differentially distributed across the genome and are associated with different forms of selection.
The Risk Mitigation Decision-Making Model for Music Therapy Services During the Covid-19 Pandemic
Authors: Morgan Rachelle , Knott David 
Published: April 2023

Abstract
When the Covid-19 pandemic began, music therapists moved quickly to adapt services across many clinical settings. Many music therapists shifted their service delivery model to telepractice. Music therapists also worked to adapt in-person services to integrate the emerging risk mitigation strategies required or recommended by various public health bodies and healthcare organizations. When public health circumstances are changing rapidly, how do music therapists make decisions regarding service delivery and risk mitigation, while balancing the requirements of public health directives and organization policies? Considering evidence-based practice and ethical thinking, we propose a risk mitigation decision-making model for providing clinical music therapy services during the Covid-19 pandemic. We consider the intersection of public health guidelines and orders, service delivery options (i.e. telepractice), and risk mitigation strategies for in-person services. Case studies follow, as well as discussion of how to use this model in future public health crises.
Effects of gluten on dyspeptic symptoms: a systematic review and meta-analysis of clinical trials
Authors: Hosseinian Seyedeh-Zeynab , Haghighatdoost Fahimeh , Hajihashemi Parisa , Adibi Peyman 
Published: April 2023

Abstract

Context
Research on the effects of gluten on dyspeptic symptoms has shown conflicting results.

Objective
The aim of this systematic review and meta-analysis of clinical trials was to assess the effects of gluten on dyspeptic symptoms.

Data Sources
A systematic search of the PubMed, ISI Web of Science, Scopus, Cochrane, and Embase online databases was performed up to May 2022.

Data Extraction
Randomized controlled trials (RCTs) and non-RCTs that examined the impact of a gluten-free diet, a low-gluten diet, or a gluten challenge on dyspeptic symptoms, including early satiety, epigastric pain, bloating, and nausea, were selected independently by 2 authors. The GRADE (Grading of Recommendations Assessment, Development, and Evaluation) framework was used to assess the certainty of the evidence. Results were pooled using a random-effects model and expressed as weighted mean differences (WMDs) and 95%CIs.

Data Analysis
Of the 7641 citations retrieved, 27 articles (18 RCTs and 9 non-RCTs) were included in the systematic review. Of those, 5 RCTs were eligible for the meta-analysis. The pooled results indicated that gluten challenge significantly increased the severity of bloating (WMD = 0.67; 95%CI, 0.37–0.97; I2 = 81.8%; n = 6), early satiety (WMD = 0.91; 95%CI, 0.58–1.23; I2 = 27.2%; n = 5), and epigastric pain (WMD = 0.46; 95%CI, 0.17–0.75; I2 = 65.8%; n = 6). However, the effect of gluten challenge on the severity of nausea (WMD = 0.13; 95%CI, −0.17 to 0.43; I2 = 0.0%, n = 5) was nonsignificant.

Conclusion
Gluten challenge significantly worsened dyspeptic symptoms, including bloating, early satiety, and epigastric pain, but did not affect nausea. These findings suggest that gluten restriction could be efficient in reducing dyspeptic symptoms. Well-designed large RCTs recruiting homogenous groups of patients with functional dyspepsia are needed to clarify the effectiveness of gluten restriction on dyspeptic symptoms.
Physical Therapist Management of Glenohumeral Joint Osteoarthritis: A Clinical Practice Guideline from the American Physical Therapy Association
Authors: Michener Lori A , Heitzman Jill , Abbruzzese Laurel D , Bondoc Salvador L , Bowne Kristin , Henning Phillip Troy , Kosakowski Heidi , Leggin Brian G , Lucado Ann M , Seitz Amee L 
Published: April 2023

Abstract
A clinical practice guideline on glenohumeral joint osteoarthritis was developed by an American Physical Therapy Association volunteer guideline development group that consisted of physical therapists, an occupational therapist, and a physician. The guideline was based on systematic reviews of current scientific and clinical information and accepted approaches for physical therapist management of glenohumeral joint osteoarthritis.
This clinical practice guideline is available in Spanish and Chinese; see Supplementary Appendix 8 for Spanish Translation and Supplementary Appendix 9 for Chinese Translation.
Evidence in support of the bone marrow as the primary lesion in axial spondyloarthritis
Authors: Maksymowych Walter P. 
Published: April 2023

Purpose of review
Over the past several decades, the concept that the primary lesion accounting for the development of axSpA is an enthesopathy has been widely accepted. However, the hallmark abnormality of axSpA occurs in the sacroiliac joint at the interface of cartilage and bone at a location remote from any anatomical enthesis. Both imaging and histopathological data from the sacroiliac joint point to immunopathogenetic events in the bone marrow as being of primary importance. Here, we discuss new developments in our understanding of immune events in the bone marrow relevant to axSpA that reinforce the need for a change in our conceptual paradigm for the pathogenesis of axSpA.

Recent findings
Human spinal enthesis samples contain myeloperoxidase-expressing cells, a marker of neutrophils, and mucosal-associated invariant T cells in the perientheseal bone marrow, which may be activated by stromal cells and circulating microbial products to express IL-17A and IL-17F and tumor necrosis factor (TNF). Evaluation of transcriptomes of monocytes from patients with axSpA demonstrates a lipopolysaccharide/TNF signature characterized by the expression of genes associated with granulocytopoietic bone marrow cells. This neutrophil-like phenotype is more evident in established and more severe axSpA and may be activated by microbial products from the gut. A similar expansion of granulocyte-monocyte progenitor-driven hematopoiesis occurs in the SKG mouse driven by granulocyte-macrophage colony-stimulating factor. Mesenchymal stem cells (MSCs) from ankylosing spondylitis patients are more likely to exhibit osteogenic differentiation than MSCs from healthy donors, which may be mediated by the formation of specific clusters of transcriptional factors, super enhancers, regulated by axSpA-associated single nucleotide polymorphisms located mostly in noncoding regions. TNF-α may enhance directional migration of AS-MSC compared with MSC from healthy controls from the bone marrow to entheseal soft tissue, which is mediated by increased expression of engulfment and cell motility protein 1 (ELMO1). TNF and IL-17A display differential effects on adipogenesis and osteogenesis of MSC in perientheseal bone marrow and soft tissue.

Summary
Bone marrow has the capacity to undergo rapid adaptation in terms of cell composition, differentiation, and immune function, resulting in inflammation and osteogenesis in axSpA.
Research progress of metabolomics in psoriasis
Authors: Guo Lan , Jin Hongzhong 
Published: April 2023

Abstract
Psoriasis is a chronic inflammatory skin disease with significant physical and psychological burdens. The interplay between the innate and adaptive immune systems is thought to contribute to the pathogenesis; however, the details of the pathogenesis remain unclear. In addition, reliable biomarkers for diagnosis, assessment of disease activity, and monitoring of therapeutic response are limited. Metabolomics is an emerging science that can be used to identify and analyze low molecular weight molecules in biological systems. During the past decade, metabolomics has been widely used in psoriasis research, and substantial progress has been made. This review summarizes and discusses studies that applied metabolomics to psoriatic disease. These studies have identified dysregulation of amino acids, carnitines, fatty acids, lipids, and carbohydrates in psoriasis. The results from these studies have advanced our understanding of: (1) the molecular mechanisms of psoriasis pathogenesis; (2) diagnosis of psoriasis and assessment of disease activity; (3) the mechanism of treatment and how to monitor treatment response; and (4) the link between psoriasis and comorbid diseases. We discuss common research strategies and progress in the application of metabolomics to psoriasis, as well as emerging trends and future directions.
Reverse effect of Semaphorin-3F on rituximab resistance in diffuse large B-cell lymphoma via the Hippo pathway
Authors: Li Qiong , Ma Naya , Li Xinlei , Yang Chao , Zhang Wei , Xiong Jingkang , Zhu Lidan , Li Jiali , Wen Qin , Gao Lei , Yang Cheng , Rao Lingyi , Gao Li , Zhang Xi , Rao Jun 
Published: April 2023

Abstract

Background:
Exploring the underlying mechanism of rituximab resistance is critical to improve the outcomes of patients with diffuse large B-cell lymphoma (DLBCL). Here, we tried to identify the effects of the axon guidance factor semaphorin-3F (SEMA3F) on rituximab resistance as well as its therapeutic value in DLBCL.

Methods:
The effects of SEMA3F on the treatment response to rituximab were investigated by gain- or loss-of-function experiments. The role of the Hippo pathway in SEMA3F-mediated activity was explored. A xenograft mouse model generated by SEMA3F knockdown in cells was used to evaluate rituximab sensitivity and combined therapeutic effects. The prognostic value of SEMA3F and TAZ (WW domain-containing transcription regulator protein 1) was examined in the Gene Expression Omnibus (GEO) database and human DLBCL specimens.

Results:
We found that loss of SEMA3F was related to a poor prognosis in patients who received rituximab-based immunochemotherapy instead of chemotherapy regimen. Knockdown of SEMA3F significantly repressed the expression of CD20 and reduced the proapoptotic activity and complement-dependent cytotoxicity (CDC) activity induced by rituximab. We further demonstrated that the Hippo pathway was involved in the SEMA3F-mediated regulation of CD20. Knockdown of SEMA3F expression induced the nuclear accumulation of TAZ and inhibited CD20 transcriptional levels via direct binding of the transcription factor TEAD2 and the CD20 promoter. Moreover, in patients with DLBCL, SEMA3F expression was negatively correlated with TAZ, and patients with SEMA3F lowTAZ high had a limited benefit from a rituximab-based strategy. Specifically, treatment of DLBCL cells with rituximab and a YAP/TAZ inhibitor showed promising therapeutic effects in vitro and in vivo.

Conclusion:
Our study thus defined a previously unknown mechanism of SEMA3F-mediated rituximab resistance through TAZ activation in DLBCL and identified potential therapeutic targets in patients.