bluuebunny/crossref_metadata_2025_split huggingface dataset:
An N6-methyladenosine-Related Classification Predicts Prognosis and Response to Immunotherapy in Prostate cancer
Authors: Zhu Yaru , Ren Zhen , Shen Jianliang , Chen Xi , Zi Tong , Qin Xin , Zhao Yan , Li Haopeng , Wu Qiang , Wu Gang , Wang Licheng 
Published: March 2023

Abstract
The m6A modification is a methylation of the adenosine N6 position, is a kind of reversible post-transcriptional modification of RNA. Moreover, this process has been shown to be associated with multiple tumor progression. Prostate cancer is the second most common cancer in men after lung cancer, and is closely related to m6A. However, previous studies were often limited to a few m6A related genes, and failed to fully understand the relationship between prostate cancer and m6A.Therefore, we used the CIBERSORT and ESTIMATE algorithms to define three m6A clusters based on the expression of m6A-related genes in 1099 PC patients. Subsequently, we identified three different m6A gene clusters based on the overlap of differentially expressed genes (DEGs) within the m6A clusters. In addition, by principal component analysis (PCA) was performed to calculate the m6A scores. The results showed that patients with high m6A scores had longer survival time and those with low scores had shorter survival time. Furthermore, the m6A score was negatively correlated with the tumor mutation burden (TMB) value of PC. Patients with higher m6A scores showed clinical benefit and advantage of immunotherapy, indicating that the m6A score is an accurate and valid predictor to assess the effect of immunotherapy. Overall, our study presents a new method for reference that can provide guidance for current immunotherapy and predict patient prognosis to help physicians make judgments about patient disease and treatment modalities, and can guide current research on immunotherapy strategies for PC.
Water Level Recognition on Resource-Constrained Equipment using Pruned YOLOv5 and Template Matching
Authors: Cai Zhaohui , Qiu Run , Liu Shubo , Chang Zhuoqing , Tu Guoqing 
Published: March 2023

Abstract
This paper proposes a novel water level recognition method for detecting and recognizing water level rulers (WLR) using limited resources of the PX30 hardware development board. Our approach focuses on optimizing network efficiency, recognition speed, and accuracy. Specifically, we use the You Only Look Once Version 5 (YOLOv5) algorithm for object detection, and use the EagleEye algorithm to prune and optimize the model, so as to reduce the number of parameters and computation, and make the model more suitable for running on resource-constrained devices. Though our proposed pruned YOLOv5n@0.6 decrease 2.1% in mean average precision (mAP@0.5) but reduces the number of parameters and computation by 42% and 40%, respectively, compared to the YOLOv5n algorithm. To recognize the water level height, we apply the multi-template matching method to identify the reading number of the water level scale and the equal-ratio method to calculate the water level height. Our method achieves an average RED of 1.26 cm and RER of 5.8% on WLRD with only average 1.16s time cost per image on PX30. The experimental results show that the proposed method has high accuracy and calculation speed and is suitable for computing equipment with limited resources.
Exploring the electrochemical performance of Ferrous Nickel Pyrophosphate Thin Film Electrodes for Potential Supercapatior Applications
Authors: Nivetha S. , Prabahar S. , Karunakaran R. T. , Ganth M. Narendhera , Boobalan T. , Dhinesh S. 
Published: March 2023

Abstract
The present work deals with the preparation of ferrous nickel pyrophosphate (Fe2Ni2P2O7) thin films via a facile approach namely chemical bath deposition. X-ray diffraction analysis evinces that the prepared Fe2Ni2P2O7 thin films are of monoclinic structure and crystallinity is improved by increase in Fe concentration with a preferential orientation along the (111) direction. The surface morphology analysis reveal the microsphere like morphology and uniform anchoring of Fe2 on Ni2P2O7 thin film surface, which is favorable for good charge transfer between the electrode and electrolyte interface. Electrochemical analysis shows that, the Fe2Ni2P2O7 film electrode offers a specific capacitance of 501 F/g with excellent electrochemical and cyclic stability. The capacitive and diffusive contributions to the total capacity of the electrode are studied by employing Trasatti and Dunn’s model. Further, the obtained value of ‘b’ in the modified power law ranges from 0.66 to 0.69 confirming both the capacitive and diffusive charge storage mechanism in the electrodes under study. The features and hybrid nature in storage property of Fe2Ni2P2O7 electrodes are unique and highlights them as promising candidates for energy storage application.
Relationship between dyadic coping and self-management in patients with chronic heart failure
Authors: Shi Yingmei , Tang Zhihong , Wang Jing , Liu Leilei , Qi Donghong , Liu Annuo 
Published: March 2023

Abstract
Background and objective
Whether the level of self-management with dyadic coping in chronic heart failure (CHF) patients remains unclear. We investigate the longitudinal changes and correlations between dyadic coping and self-management in patients with CHF.
Methods
In this study, 106 pairs of chronic heart failure patients and spouses treated in the Department of Cardiology of the Hefei First People's Hospital were selected as study subjects between September 2020 and September 2021. The dyadic coping scale and self-management scale were used for the follow-up survey to analyze the changes and correlation between patients' self-management ability and dyadic coping.
Results
We followed 106 patients (19 patients lost) CHF for one year, whose overall self-management ability showed a significant decreasing trend. Male patients displayed lower self-management ability than that of female patients, especially at 6 months and 12 months of follow-up (P<0.05). All patients and spouses showed similar decreasing trend in stress communication scores, cooperation scores, and negative coping scores, but the decreasing trend were more pronounced for male patients. There was a significant positive correlation between female patients' self-management ability and dyadic coping was observed at admission, 6 months and 12 months after discharge (P<0.05). While there was no significant correlation between self-management ability and dyadic coping in male patients at admission and 12 months of discharge (P>0.05), a significant correlation was monitored at 6 months of discharge (P<0.05). There was a significant positive correlation between self-management ability and dyadic coping of spouses in male patients (P<0.05).
Conclusion
Via elevating the dyadic coping level of patients' spouses, especially male spouses, the self-management ability of patients can be improved. The aforementioned findings provide a foundation for the future clinical nursing interventions to improve the life quality of CHF patients.
Measuring hospital technical efficiency with data envelopment analysis, application to 20 Paris public university hospitals
Authors: Hadji Brahim , Degoulet Patrice 
Published: March 2023

Abstract
Objective
The purpose of this study is the investigation of the variation in hospitals' TE scores using Data Envelopment Analysis (DEA) method, when changing output unit measures. Associations between input and output variables are additionally tested using structural equation modelling (SEM) tools.
Methods
The study is based on two DEA models on data extracted from 20 university teaching Paris hospitals for the period 2009–2017. In the first model (M1), hospital resources are considered as input indicators and hospitals' activities as hospital productivity outputs. In the second model (M2) the hospitals' financial outcomes are used as outputs while keeping the same inputs.
Results
A clear difference in TE efficiency results is observed between the M1 and M2 model, mainly some hospitals are technically efficient when using hospitals' activities variables as outputs and inefficient when using hospitals' financial outcomes and vice versa. SEM analysis show that the inpatient revenue is predicted by the number of staffed beds, the number of medical staff but not the number of nurses or nonmedical nonnursing staff. The number of inpatient days is impacted by the number of outpatient visits, in addition to the number of staffed beds and the number of training medical staff.
Conclusion
In the aim to give the right decision-making aid, as a tool to help hospitals' decision-makers, separate analysis using activity and financial outcomes should be performed and analyzed in the context of the underlying health financing system.
Structural Form and Conceptual Design of Novel Truss-Arch Bridge with 1000 m Scale
Authors: Xie Xiaoli , Song Huilan , Yu Zecheng 
Published: March 2023

Abstract
The main span of conventional arch bridges is difficult to reach 1000 m due to the sharp decline of mechanical properties (e.g., structural stiffness, natural frequency and stability). In order to overcome this limitation, the structural form and conceptual design of a novel truss-arch bridge with 1000 m scale was proposed. Firstly, a novel truss-arch bridge was presented based on the structural form of conventional deck arch bridges by introducing auxiliary arch and substituting columns for triangular network consisting of web members. The mechanical rationalities of this structural form were clarified. Then, a conceptual design of new truss-arch bridge with a span of 960 m are performed and the main components (e.g., main/auxiliary arch, triangular truss network and main beam) are designed. Finally, the structural responses of new truss-arch bridge were numerically investigated based on finite element analysis (FEA) by comparing with conventional deck arch bridges. The numerical analysis demonstrates shows that the proposed bridge combines the complementary strength of both arch and truss structures. As compared to conventional deck arch bridge, the stress, stiffness and stability of the proposed bridge have greatly improved and meet the requirements of the design codes. Quantifications show that the stress and displacement are reduced by 10% and 15%, while the stability and natural frequency are increased by 35% and 24%. The conceptual design of the proposed bridge can provide an alternative solution for the construction of super-long span bridges.
Energy Efficient Adaptive Power Transmission for Free Space Optical
Authors: Hamouda Yousef E. M. 
Published: March 2023

Abstract
The Free Space Optical (FSO) is a wireless optical system that has many advantages such as low installation time, low installation cost, flexible deployment, high data rate, high data security, and unlicensed spectrum usage. However, FSO links degrade with bad weather conditions including rain, fog, and snow. In this paper, Energy Efficient Adaptive Power Transmission (EEAP) system is proposed to adaptively adjust the required minimum transmission power, based on the distance between the transmitter and receiver under real weather conditions data in Gaza Strip. The required transmission power is minimum transmission power at the transmitter that guarantees a received Signal to Noise (SNR) at the receiver of predefined minimum value. If the required transmission power exceeds the transmission capability of the receiver, EEAP performs a decision making of classifying the FSO link as unviable. In case of unavailable FSO channel, other communication systems such as Radio Frequency (RF) and optical fibre is employed for transmission. In addition, the effect of weather conditions in Gaza Strip in the FSO channel is analysed in this paper. Simulation results show that compared with other fixed transmission power schemes, the proposed EEAP scheme improves the energy efficiency of the transmitter and the link availability of FSO links.
Surgical results and quality of life after a single-stage posterior transpedicular approach for circumferential epidural decompression in patients with thoracolumbar spine metastasis
Authors: Niu Jianfang , Zhao Zhiqing , Wang Jichuan , Yan Taiqiang , Guo Wei , Yang Rongli , Tang Xiaodong 
Published: March 2023

Abstract
Objective: The primary aim of this study was to evaluate the effect of palliative surgery using posterior transpedicular approach (PTA) with posterior instrumentation on pain response and quality of life (QoL) in patients with metastatic thoracic and lumbar tumors.
Methods:From 2018 to 2019, 39 patients with metastatic thoracic and/or lumbar spine tumors were prospectively enrolled to measure the reduction in pain and the changes in QoL after surgical decompression with posterior instrumentation via PTA. The patient group was composed of 27 men and 12 women with a mean age of 60 years (range, 28-92 years). Pain response was measured using the VAS and neurologic status was evaluated using Frankel grades. QoL was assessed with use of the EORCT QLQ-BM22 questionnaire before surgery (baseline) and at one, three, six, and twelve months after surgery. The survival times of all the patients were also collected.
Results: The VAS score was reduced from 7.10 preoperatively to 3.10 postoperatively (P＜0.05). All the patients with pain showed either an improvement or a similar pain level after surgery. Postoperatively, 19 patients showed improvement neurologic deficits; 7 cases improved from Frankel grade C to D, 5 cases from grade C to E, and 7 cases from grade D to E. Although 20 (51.3%) of the 39 patients remained in the same Frankel grade postoperatively, most improved clinically. The quality of life improvement of the patients was also evident after treatment. Paired-samples T test examination of the postoperative scores showed a significant improvement in terms of pain location, pain severity and performance status (P＜0.01). Compared with the preoperative score, the one month postoperative score of functional interference was significantly improved (63.6 vs. 34.5, P＜0.01). There were no significant changes in social or psychological functioning. Three patients experienced cerebrospinal fluid leakage postoperatively, and they were all successfully managed by lying flat without the pillow. One patients experienced rod breakage, at 10 months after suegery. All the patients were alive at 3 months; however, 7 patients died within 3-6 months, and another 9 patients died from the disease within 6-12 months.
Conclusions: The present feasibility study found that the application of the PTA for decompression and fusion in patients with spinal metastases is beneficial for achieving prompt and sustained pain relief, reducing neurologic deficits and improving functional outcomes, health utilities, and HRQoL.
Knowledge Mapping of Immune checkpoint inhibitor-related Pneumonitis: A Bibliometric Analysis (2011–2022)
Authors: Cao Kefei , Wang Yulong , Qin Qin 
Published: March 2023

AbstractBackground Immune checkpoint inhibitors (ICIs) are widely used in various tumor patients at present. Although the application of them demonstrates remarkable efficacy, ICIs can also result in some immune-related adverse events (irAEs) involving almost all the organs of the body, among which ICI-related pneumonitis (ICIP) is one main area of concerns. However, there has been no bibliometric analysis in this field so far. This study is designed to provide the basics of the knowledge framework and research frontiers about ICIP through bibliometrics. Method To learn more about ICIs development, publications from 2011 to 2022 were retrieved from Web of Science Core Collection (WoSCC) database. Microsoft Office Excel 2021 was used to conduct quantitative analysis of publication. Meanwhile, VOSviewers, CiteSpace and R package “bibliometrix” were used to perform bibliometric data analysis. Results 746 articles from 53 countries headed by United states and China were included. The University of Texas MD Anderson Cancer Center, Johns Hopkins University, Dana-Farber Cancer Institute, Memorial Sloan Kettering Cancer Center and Harvard Medical School were the main research institutions. Frontiers in Oncology was the most popular journal in this field, and Journal of Clinical Oncology was the most frequently cited journal. These publications came from 5251 authors among whom Naidoo Jarushka, Hodi F Stephen and Nishino Mizuki had the most publications and Brahmer Julie R was the highest co-cited author. “Risk factors”, “efficacy”, “management”, and “radiological features” were the primary keywords of research hotspots and frontiers. Conclusion This is the first bibliometric study that comprehensively illustrates the development trends of ICIP, identifying recent hot directions and providing a reference for scholars studying this field.
Learning curve of intracorporeal anastomosis in laparoscopic colectomy for right side colon cancer: a cumulative sum analysis
Authors: Ishizaki Tetsuo , Mazaki Junichi , Kasahara Kenta , Tago Tomoya , Udo Ryutaro , Nagakawa Yuichi 
Published: March 2023

Abstract
Purpose: Recently, laparoscopic colectomy with intracorporeal anastomosis for colon cancer has gained popularity due to evolution of the laparoscopic linear stapler device and improved techniques from laparoscopic surgeons. However, there are technical difficulties associated with intracorporeal anastomosis. To clarify the number of cases that are required for laparoscopic surgeons to master the technique of intracorporeal anastomosis in right side colon cancer.
Methods:In this retrospective single-center study, 51 consecutive patients who underwent intracorporeal overlap anastomosis, between July 2018 and March 2020, by one laparoscopic surgeon were selected. Clinicopathological and perioperative data were obtained from our database. The learning curves of intracorporeal anastomosis time (IAT) was created using the cumulative sum (CUSUM) method.
Results: The CUSUM score for IAT increased as the number of operative cases progressed, up to the 20th case (Phase 1), after which it started to decrease (Phase 2). Compared to the initial learning phase (Phase 1), the master phase (Phase 2) had a significantly faster IAT (p < 0.001), significantly decreased incidence of organ/space surgical site infection (p = 0.009), and significantly decreased postoperative hospital stay (p = 0.021).
Conclusion:In our study, 20 cases were required for a laparoscopic surgeon to achieve expertise when conducting intracorporeal anastomosis in laparoscopic colectomy for right side colon cancer. It was suggested that proficiency in intracorporeal anastomosis may contribute to a reduction in the incidence of organ/space surgical site infections and postoperative hospital stay.
Distribution and abundance of Aedes aegypti and Aedes albopictus (Diptera: Culicidae) in Benin, West Africa
Authors: Padonou Germain Gil , Konkon Alphonse Keller , Salako Albert Sourou , Zoungbédji David Mahouton , Ossé Razaki , Sovi Arthur , Azondekon Roseric , Sidick Aboubakar , Ahouandjinou Juvénal Minassou , Adoha Constantin Jesukèdè , Sominahouin André Aimé , Tokponnon Filemon , Akinro Bruno , Sina Haziz , Baba-Moussa Lamine , Akogbeto Martin 
Published: March 2023

Abstract
Background
Updated information on the distribution and abundance of Aedes aegypti and Aedes albopictus is crucial to prepare African countries like Benin for possible arbovirus outbreaks. This study aims to evaluate the geographical distribution, the abundance, and the biting behaviors of these two vectors in Benin.
Methods
Three sampling techniques (Human Landing Catch (HLC), Larval sampling, and Ovitrapping) were used to collect both immature and adult stages of Aedes spp in 23 communes located along the North-South and East-West transect of Benin. Adult Aedes mosquitoes were collected indoors and outdoors using HLC. Mosquito eggs, larvae, and pupae were collected from containers and ovitraps and morphologically identified, then confirmed by Polymerase Chain Reaction (PCR).
Results
Overall, 12,428 adult specimens of Aedes spp, out of which 76.53% (n = 9508) and 19.32% (n = 2400) were morphologically identified as Ae. aegypti, and Ae. albopictus respectively. Geographically, Ae. aegypti was encountered across the North South transect unlike Ae. albopictus which was only encountered in the southern part of the country, with a strong preponderance in Avrankou and Ifangni. Furthermore, exophagic behaviors were observed in both vectors.
Conclusion
This updated distribution of Aedes mosquitoes in Benin will help to accurately identify areas at risk of arboviruses, to better plan future vector control interventions.
The Psychological Indicators of Success in Ultrarunning - A Review of the Current Psychological Predictors in Ultrarunning
Authors: Thornton Owen R. , Ly Sophia , Colón Isabella , Cole Hunter , Li Wenjun 
Published: March 2023

Abstract
Ultrarunning has grown over 345% in the last ten years alone. During these events, which typically last between 6 hours and multiple days, athletes of varying experience and ability must cope with the psychological means of endurance while managing intense emotions and fatigue. Despite rapid growth in the sport, research on ultrarunners psychology has yet to be performed. No review has analyzed the psychological advantages indicating success in ultra-running. This review summarizes the current literature on the psychological indicators of ultrarunning success. Four databases were electronically searched between December 1, 2022, and January 1, 2023, to help coaches, physicians, sports therapists, athletes, and everyday people understand how to cope with and overcome psychological challenges amidst life and racing while identifying research gaps. Successful ultramarathoners had higher levels of self-efficacy, mental toughness, emotional intelligence, and lower mood variability. These findings suggest that having cognitive strategies to maintain mood stability and a common total mood disturbance may be vital to success in ultra-running. Although existing literature investigates ultra-athletes’ mindsets, further research, specifically on psychological traits of success in endurance sports, is warranted to gain greater depth on each psychological indicator that constructs successful ultrarunners' great mindset.
Impact of Environmental Degradation and Climate Change on Water Quality in North Karoun Basin (Iran)
Authors: Saberi Bijan , Rahimi Dariush , Dastjerdi Javad Khoshhal 
Published: March 2023

Abstract
Drought, climate change, floods, human activities, land use change and salt domes lead to a decrease in surface water quality.KNB is one of the primary sources of drinking and irrigation water. The results of 2828 water sample analyses between 1991–2019 reveal that the concentration of chemical elements in the surface water of the NKB is subject to seasonal changes, and there exists a direct relation between precipitation and discharge and the concentration of these effluents’ elements. Erosion of karst formations, chemical fertilizers, deforestation, and dissolution of salt domes contribute to the primary sources of water pollution in NKB. An increase in precipitation and discharge leads to an increase in the concentration of chemical pollutants. Climate change in RCP4.5 and RCP8.5 scenarios reveal that due to an increase in maximum daily precipitation at the end of winter (March) and beginning of spring (April) in the subsequent decades and the occurrence of severe floods, the erosion of Karst and agricultural lands, dissolution of chemical fertilizers and further dissolution of salt domes increase the concentration of chemical pollutants in KNB and lead to a water quality decline.