bluuebunny/crossref_metadata_2025_split huggingface dataset:
New strategies for an old problem - Oral vaccines research
Authors: Norton Elizabeth B 
Published: January 2025

New strategies for an old problem - Oral vaccines research
Despite their advantages, oral vaccines encounter several challenges. Professor Elizabeth Norton from Tulane University discusses how her team is addressing these issues and their research on developing and testing dmLT and saponin combination adjuvants. The gut is home to a remarkable concentration of the body’s immune cells, particularly antibody-secreting plasma cells. It serves as a critical site for interactions with microbes, exposure to pathogens, and maintaining overall health. Globally, several human vaccines leverage oral delivery routes due to their ability to stimulate mucosal immunity and suitability for mass immunization campaigns. (1) Notable licensed oral vaccines include live-attenuated vaccines for polio, rotavirus, Salmonella typhi, and adenovirus, as well as whole-inactivated vaccines for cholera. These vaccines offer additional benefits, such as eliminating the need for syringes and needles. This is particularly valuable in resource-limited settings, where needle reuse can lead to accidental transmission of bloodborne infections like HIV and hepatitis, and it also mitigates needle-related aversion among individuals.
Forging unity: Interagency collaboration in hybrid warfare
Authors: Mattingsdal Jostein 
Published: January 2025

Forging unity: Interagency collaboration in hybrid warfare
Jostein Mattingsdal explores leadership’s critical role in maximizing interagency collaboration’s effectiveness in hybrid warfare scenarios. Hybrid warfare challenges traditional security paradigms by blurring the distinctions between war and peace, combatants and non-combatants, and military and civilian domains. (1) It can be conducted by both state and non-state actors to achieve strategic objectives and manifests in various forms. It can include disinformation campaigns designed to erode public trust, subversion tactics aimed at destabilizing nations, and overt combat actions disrupting national sovereignty. Addressing these threats requires a coordinated response that harnesses the operational capabilities of different agencies. (2) However, conventional mindsets among key leaders can hinder this essential collaboration, emphasizing the need for a shift toward embracing the cross-sectoral advantages of collaborative efforts.
Philosophy: Environmental risk policy and public law
Authors: Gillroy John Martin 
Published: January 2025

Philosophy: Environmental risk policy and public law
John Martin Gillroy is Professor of Philosophy, Law & Public Policy at Lehigh University. Here, he navigates philosophy with a special focus on environmental risk within the realms of policy and public law. Human beings constantly look for assurances against uncertainty. Scientific data provides assurance, but it only examines the surface ‘facts’ of the causal world. Religion provides assurance, but it requires a belief in and allegiance to a particular definition of God. Philosophy is a hedge against uncertainty that is more essential than science. It does not require a single theological belief and gives one access to a range of systematic, logical arguments for applying practical reason to choices in an uncertain world.
Cell biology research: The mystery of cholesterol homeostasis
Authors: Ueda Kazumitsu 
Published: January 2025

Cell biology research: The mystery of cholesterol homeostasis
Kazumitsu Ueda, PhD from Kyoto University, WPI-iCeMS, unveils the mystery of cholesterol homeostasis in this cell biology research focus. Cholesterol is a crucial component of the plasma membrane (PM) that surrounds every human cell, helping to maintain a distinct intracellular environment from the external one. While some cholesterol in the body is obtained from daily food, it is synthesised in all body cells, and cellular cholesterol concentration is highly regulated. However, cholesterol has gained a bad reputation for harming health. In this article, the physiological role of cholesterol will be reconsidered.
Molecular Insights: Gene Expression in HCC and Testicular Cancer among ALD Patients.
Authors: Fatima Hooriya , Maqbool Humayoun Huma , Ahmad Husna , Sheikh Nadeem 
Published: January 2025

Background: Alcohol-associated liver disease (ALD) leads to anomalies of hepatocellular carcinoma (HCC), and steatohepatitis. Though tremendous efforts have been made during the past 2 decades, ALD pathogenesis remains obscure. Currently, computational data analysis related to the residues of ALD patients is not widely emphasized, so most attention is needed on differentially expressed genes associated with HCC.
Methodology: A comparison between GSM4194985 (Healthy) and GSM4194987 (ALD) was conducted through the GEO database with the accession ID GSE141100 in the form of Raw RNA counts. IDEP analyzed data through bicluster heatmaps for upregulated and downregulated genes for potential effects of ALD on the patients followed by pathway analysis through Reactome.
Results: The study revealed the downregulated expression of KCNK15 alongside the upregulation of MLXIPL and ART4 owing to ALD discerning their progression in HCC. As KCNK15 and MLXIPL both are involved in metabolism, their pathway analysis alleged the dysregulation of ion and insulin homeostasis respectively could lead to the progression of HCC. ADH1B downregulation raises the possibility of poor alcohol metabolism, which exacerbates liver damage. Dysregulation of MLXIPL, KCNK15, and ART4 may accelerate the development of HCC. Furthermore, this study suggests that impaired spermatogenesis in ALD patients is associated with overexpression of C5orf58, KCNE1, and AKAP3.
Conclusion: This study reveals the inclination of developing HCC in ALD patients based on the differential expression of KCNK15, MLXIPL, and ART4 genes and liver toxicity by ADH1B. The upregulation of C5orf58, KCNE1, and AKAP3 may lead to the defective spermatogenesis that may contribute to the development of testicular cancer owing to the upregulation of C5orf58, KCNE1, and AKAP3 in spermatogenesis.
Pengaruh Medan Magnet Elektromagnetik ELF 750 µT Terhadap Ketahanan Tempe
Authors: Sasikirana Berlian Nur , Putri Diana Ragilia , Astanafa Delania Sylva , Putri Elsa Ananda , Zakkiyah Halwa Fathimah , Nur I Meylan Aisyatun , Elizah Nur , Yushardi Yushardi , Arimukti Dyah Arum 
Published: January 2025

Tujuan dari penelitian ini adalah untuk mengetahui bagaimana pengaruh medan magnet elektromagnetik ELF terhadap ketahanan tempe. Medan elektromagnetik (ELF) adalah sejenis radiasi non-pengion karena spektrum gelombang elektromagnetiknya memiliki frekuensi di bawah 300 Hz. Salah satu manfaat dari gelombang ELF yaitu dapat dimanfaatkan untuk mengawetkan bahan pangan. Bahan pangan yang sering dijumpai, kerap memiliki daya tahan atau masa simpan yang terbatas, gelombang ELF ini dapat dimanfaatkan untuk menambah daya tahan atau masa simpan bahan makanan seperti tempe. Beberapa Hasil penelitian menunjukkan bahwa paparan medan magnet ELF dapat meningkatkan pertumbuhan bakteri tertentu, yang berperan penting dalam proses fermentasi makanan seperti tempe. Pada penelitian kali ini kita menggunakan metode eksperimen laboratorium yang merupakan metode penelitian dengan tujuan menjelaskan hubungan antara sebab dan akibat dari satu variabel dengan variabel yang lain. Hasil dari penelitian menunjukkan bahwa dengan pemberian paparan medan magnet ELF, kualitas fermentasi meningkat, memperpanjang masa simpan, dan menjaga stabilitas kualitas tempe, sehingga teknologi ini memiliki potensi besar untuk diterapkan secara luas dalam industri pangan.
Noemia, Paulina e as poéticas nos tempos
Authors: Vergueiro Filho Carlos Eduardo Pinto 
Published: January 2025

Este artigo visa construir uma relação entre duas escritoras moçambicanas a partir dos textos presentes em Sangue Negro (2018), de Noemia de Sousa, e Niketche : Uma história de poligamia (2022), de Paulina Chiziane. Algumas categorias de análise foram elencadas para realizar a comparação: oralidades nos textos a partir das culturas endógenas; vozes poéticas, bem como a posição da narradora na ficção; experiência e contaminações do real no texto ficcional. O objetivo do artigo é dissertar sobre as permanências e mudanças na literatura moçambicana de autoria feminina em tempos históricos que vão do colonial ao pós-independência. O que aproxima as duas escritoras que viveram épocas diferentes? É possível uma aproximação da linguagem (ritmo, figuras, imagens, pontuações e outras) e das tópicas (lugar do feminino, liberdade, opressão, mundo do trabalho e outras) levantadas em seus respectivos textos? Como eles dialogam com os momentos históricos vividos pelas autoras e a formação da literatura moçambicana ao longo desse período? O texto será iniciado com um conjunto de questões para buscar possibilidades de contato visando a aproximação deles, bem como a integração com leitores de língua portuguesa. Por fim, nas considerações finais serão colocadas algumas hipóteses conclusivas, assim como alternativas investigativas posteriores que podem ser desdobradas.
Raízes e Ressonâncias a estética literária de Alice Goretti Pina na Literatura Contemporânea de São Tomé e Príncipe
Authors: Alves Roberta Maria Ferreira 
Published: January 2025

Alice Goretti de Pina é uma escritora de São Tomé e Príncipe, cuja obra se caracteriza pela profunda conexão com as raízes culturais e tradições de seu país. Nascida como a oitava filha de Alice e Protásio, Goretti Pina desenvolveu desde cedo um interesse pela literatura, que se consolidou ao longo dos anos e a levou a se tornar uma voz importante da cena literária são-tomense. Sua produção literária é variada, abrangendo desde narrativas ficcionais, poesia e literatura infantil. Em suas obras, é comum encontrar uma abordagem intimista e poética da condição humana, frequentemente permeada por temas como a identidade, a cultura e a preservação das tradições de São Tomé e Príncipe. Goretti Pina é reconhecida por sua habilidade em equilibrar a preservação da herança cultural são-tomense com uma abordagem inovadora e contemporânea, que busca dialogar com um mundo cada vez mais globalizado sem perder de vista suas origens.
Testimonios de Transformación
Authors: Casillas Alcalá María Teresa 
Published: January 2025

Este volumen especial rinde un homenaje a la visión y al gran esfuerzo del Dr. Julián Gascón Mercado, un hombre íntegro y sensible a las necesidades de los nayaritas. Estaba seguro que la educación es una herramienta poderosa para transformar la vida de las personas y que la creación de una universidad en el Estado de Nayarit, significaba que los jóvenes no tendrían qué abandonar a su estado natal para buscar una educación superior de calidad.
ANALYSIS OF THE LABORATORY'S INTERNAL CONTROL
Authors: Дягилева Дарья Андреевна 
Published: January 2025

В данной работе осуществляется изучение аспектов, связанных с организацией внутреннего контроля в лабораториях, включая ключевые функции и принципы эффективности таких процедур. Рассматриваются фундаментальные понятия управления качеством внутреннего контроля лаборатории, подчеркивается важность обоснованного внедрения проверок
This paper examines aspects related to the organization of internal control in laboratories, including key functions and principles of effectiveness of such procedures. The fundamental concepts of quality management of the laboratory's internal control are considered, and the importance of sound implementation of inspections is emphasized
NEW FORMS OF EXISTENCE: A PHILOSOPHICAL UNDERSTANDING OF DIGITAL IMMORTALITY AND ITS CONSEQUENCES
Authors: Сметана Владимир Васильевич 
Published: January 2025

Данная статья посвящена философскому исследованию новых форм существования, которые могут возникнуть в результате развития цифровых технологий, в частности, в контексте цифрового бессмертия и трансгуманизма. В работе анализируются философские аспекты виртуальной реальности, искусственного интеллекта и трансгуманизма, а также их влияние на понимание человека, реальности и будущего. Особое внимание уделяется онтологическим и эпистемологическим вопросам, связанным с виртуальной реальностью и гипотезой симуляции. Рассматривается проблема различения реальности и симуляции, а также философские импликации возможности того, что наш мир является компьютерной симуляцией. В контексте искусственного интеллекта (ИИ) анализируются проблемы сознания, идентичности и гибридных форм жизни. Рассматриваются этические и экзистенциальные вызовы, связанные с интеграцией человеческого сознания с искусственным интеллектом, а также перспективы развития ИИ и его влияние на человечество. Статья представляет собой междисциплинарное исследование, объединяющее философию, этику, футурологию и философию технологий. Она вносит вклад в развитие философии сознания, онтологии, этики и философии технологий, а также способствует осмыслению перспектив человечества в эпоху цифровых технологий и развития искусственного интеллекта
This article is devoted to the philosophical study of new forms of existence that may arise as a result of the development of digital technologies, in particular, in the context of digital immortality and transhumanism. The work analyzes the philosophical aspects of virtual reality, artificial intelligence and transhumanism, as well as their impact on the understanding of man, reality and the future. Particular attention is paid to the ontological and epistemological issues related to virtual reality and the simulation hypothesis. The problem of distinguishing reality from simulation is considered, as well as the philosophical implications of the possibility that our world is a computer simulation. In the context of artificial intelligence (AI), the problems of consciousness, identity and hybrid forms of life are analyzed. Ethical and existential challenges associated with the integration of human consciousness with artificial intelligence are considered, as well as the prospects for the development of AI and its impact on humanity. The article is an interdisciplinary study that combines philosophy, ethics, futurology and the philosophy of technology. It contributes to the development of the philosophy of consciousness, ontology, ethics and philosophy of technology, and also helps to understand the prospects of humanity in the era of digital technologies and the development of artificial intelligence
IMPORTANCE OF THE LABORATORY PRODUCTION CONTROL PROGRAM FOR IDENTIFICATION OF THE SAFETY LEVEL
Authors: Дягилева Дарья Андреевна 
Published: January 2025

В статье изучено значение идентификации уровня опасности процессов и объектов в соответствии с программой производственного контроля. Исследовано функционирование лабораторной деятельности с полным соблюдением установленных мер, методик и структуры в рамках макрообразующего процесса, состоящего из отдельных подпроцедур со специфическими входными/выходными параметрами, ресурсным обеспечением и алгоритмами управления
The article studies the importance of identifying the hazard level of processes and objects in accordance with the production control program. The functioning of laboratory activities with full compliance with established measures, methods and structure within the framework of the macro-forming process, consisting of individual subprocedures with specific input/output parameters, resource provision and control algorithms, is studied
GENERAL ONTOLOGICAL GROUNDS OF MATERIAL OBJECTS OF THE SURROUNDING WORLD
Authors: Карпин Владимир Александрович , Шувалова Ольга Ивановна 
Published: January 2025

В основании любых научных исследований должна лежать общенаучная картина мира, которая характеризуется историческим динамизмом. Основой научного знания всегда считалось открытие различных законов. Но для полноценного теоретического знания этого уровня оказалось явно недостаточно. Важнейшим этапом является построение некоторых общих предположений, так называемых принципов, исходя из которых необходимо вывести все вытекающие отсюда следствия. Общими онтологическими основаниями современной теоретической науки являются фундаментальные философские принципы и принципы универсального эволюционизма, объединяющие в единое целое идеи системного и эволюционного подходов
Any scientific research should be based on a general scientific picture of the world, which is characterized by historical dynamism. The discovery of various laws has always been considered the basis of scientific knowledge. But this level was clearly not enough for a full-fledged theoretical knowledge. The most important stage is the construction of some general assumptions, the so-called principles, based on which it is necessary to deduce all the consequences that follow from this. The general ontological foundations of modern theoretical science are the fundamental philosophical principles and principles of universal evolutionism, combining the ideas of systemic and evolutionary approaches into a single whole
PURE CULİNARY PHRASEOLOGY
Authors: Мамедзаде Алмаз Темур кызы 
Published: January 2025

В языкознании фразеологизмы объединяются в тематические группы в разных областях в зависимости от содержания, выраженного в них словами. Фразеологизмы, связанные с поварской профессией азербайджанского языка, входят в группу фразеологизмов, сформированных на основе определенных профессиональных сфер. Помимо кулинарной фразеологии здесь приведены и другие профессиональные группы фразеологизмов и примеры, существующие в языке. Кулинарная фразеология делится на исконно кулинарную фразеологию и кулинарную фразеологию используемой совместно с другими по содержанию. Подчеркивается, что кулинарная фразеология выражает семантику, связанную с питанием. Актуальностью и научной новизной темы является вопрос изучения фразеологии по тематическим группам, что является одной из проблем фразеологии азербайджанского языка, ожидающей точного исследования. Четко обозначены названия нескольких групп профессий, охваченных профессиональной фразеологией, среди них широко обсуждается кулинарная фразеология
Linguistics, phraseological units are combined in thematic groups in different areas depending on the content expressed by the words in them. Phraseology related to the cooking profession of the Azerbaijani language is part of a group of phraseological units formed on the basis of a certain field of profession. In addition to culinary phraseology, other professional- specialty phraseology groups and examples that exist in the language are given here. Culinary phraseology is divided into pure culinary phraseology and culinary phraseology used together with other groups. It is emphasized that culinary phraseology namely conveys the semantics of nutrition. The topic of relevance and scientific novelty is the issue of studying phraseology in thematic groups, which is one of the problems of language phraseology that awaits precise research. He clearly outlined the names of several groups of professions covered by professional phraseology, among them culinary phraseology is widely discussed
ФИЗИЧЕСКАЯ КУЛЬТУРА И СПОРТ В СИСТЕМЕ ФОРМИРОВАНИЯ ЛИЧНОСТИ СТУДЕНЧЕСКОЙ МОЛОДЕЖИ
Authors: Легова Екатерина Сергеевна 
Published: January 2025

В статье рассмотрена роль физической культуры и спорта в формировании основных качеств и свойств личности. Установлено, что занятия физическими упражнениями, спортом, если они педагогически правильно организованы, дают возможность существенно и целенаправленно влиять на формирование гармонично развитой личности
The article examines the role of physical culture and sports in the formation of basic qualities and personality traits. It has been established that physical exercises and sports, if they are pedagogically properly organized, make it possible to significantly and purposefully influence the formation of a harmoniously developed personality
АНАЛИЗ РЕЗУЛЬТАТОВ ДИАГНОСТИЧЕСКОГО ТЕСТИРОВАНИЯ ПО ОСНОВАМ БЕЗОПАСНОСТИ ЖИЗНЕДЕЯТЕЛЬНОСТИ ПЕРВОКУРСНИКОВ ЕСТЕСТВЕННО-ГЕОГРАФИЧЕСКОГО ФАКУЛЬТЕТА ТУВГУ
Authors: Доржу Урана Валериевна 
Published: January 2025

В статье даны результаты диагностического тестирования студентов-первокурсников, поступивших в 2024 -2025 уч.г. на естественно-географический факультет Тувинского государственного университета. В результате выявлено, что уровень знаний студентов первого курса по дисциплине «Основы безопасности жизнедеятельности», полученных на базе среднего общего образования, низкий
The article presents the results of diagnostic testing of first-year students enrolled in the 2024-2025 academic year at the Faculty of Natural Geography of Tuvan State University. As a result, it was revealed that the level of knowledge of first-year students in the discipline "Fundamentals of life safety", obtained on the basis of secondary general education, is low
Generative Artificial Intelligence in Anatomic Pathology
Authors: Brodsky Victor , Ullah Ehsan , Bychkov Andrey , Song Andrew H. , Walk Eric E. , Louis Peter , Rasool Ghulam , Singh Rajendra S. , Mahmood Faisal , Bui Marilyn M. , Parwani Anil V. 
Published: January 2025

Context.—
Generative artificial intelligence (AI) has emerged as a transformative force in various fields, including anatomic pathology, where it offers the potential to significantly enhance diagnostic accuracy, workflow efficiency, and research capabilities.

Objective.—
To explore the applications, benefits, and challenges of generative AI in anatomic pathology, with a focus on its impact on diagnostic processes, workflow efficiency, education, and research.

Data Sources.—
A comprehensive review of current literature and recent advancements in the application of generative AI within anatomic pathology, categorized into unimodal and multimodal applications, and evaluated for clinical utility, ethical considerations, and future potential.

Conclusions.—
Generative AI demonstrates significant promise in various domains of anatomic pathology, including diagnostic accuracy enhanced through AI-driven image analysis, virtual staining, and synthetic data generation; workflow efficiency, with potential for improvement by automating routine tasks, quality control, and reflex testing; education and research, facilitated by AI-generated educational content, synthetic histology images, and advanced data analysis methods; and clinical integration, with preliminary surveys indicating cautious optimism for nondiagnostic AI tasks and growing engagement in academic settings. Ethical and practical challenges require being addressed by rigorous validation, prompt engineering, federated learning, and synthetic data generation to help ensure trustworthy, reliable, and unbiased AI applications. Generative AI can potentially revolutionize anatomic pathology, enhancing diagnostic accuracy, improving workflow efficiency, and advancing education and research. Successful integration into clinical practice will require continued interdisciplinary collaboration, careful validation, and adherence to ethical standards to ensure the benefits of AI are realized while maintaining the highest standards of patient care.