bluuebunny/crossref_metadata_2025_split huggingface dataset:
The biomarkers discovery of hyperuricemia and gout: proteomics and metabolomics
Authors: Wu Xinghong , You Chongge 
Published: January 2023

Background
Hyperuricemia and gout are a group of disorders of purine metabolism. In recent years, the incidence of hyperuricemia and gout has been increasing, which is a severe threat to people’s health. Several studies on hyperuricemia and gout in proteomics and metabolomics have been conducted recently. Some literature has identified biomarkers that distinguish asymptomatic hyperuricemia from acute gout or remission of gout. We summarize the physiological processes in which these biomarkers may be involved and their role in disease progression.

Methodology
We used professional databases including PubMed, Web of Science to conduct the literature review. This review addresses the current landscape of hyperuricemia and gout biomarkers with a focus on proteomics and metabolomics.

Results
Proteomic methods are used to identify differentially expressed proteins to find specific biomarkers. These findings may be suggestive for the diagnosis and treatment of hyperuricemia and gout to explore the disease pathogenesis. The identified biomarkers may be mediators of the link between hyperuricemia, gout and kidney disease, metabolic syndrome, diabetes and hypertriglyceridemia. Metabolomics reveals the main influential pathways through small molecule metabolites, such as amino acid metabolism, lipid metabolism, or other characteristic metabolic pathways. These studies have contributed to the discovery of Chinese medicine. Some traditional Chinese medicine compounds can improve the metabolic disorders of the disease.

Conclusions
We suggest some possible relationships of potential biomarkers with inflammatory episodes, complement activation, and metabolic pathways. These biomarkers are able to distinguish between different stages of disease development. However, there are relatively few proteomic as well as metabolomic studies on hyperuricemia and gout, and some experiments are only primary screening tests, which need further in-depth study.
Evaluating the effect of the incidence angle of ALOS-2 PALSAR-2 on detecting aquaculture facilities for sustainable use of coastal space and resources
Authors: Murata Hiroki , Fujii Toyonobu , Yonezawa Chinatsu 
Published: January 2023

Background
Driven by the growing world population, aquaculture plays a key role in meeting the increasing demand for food. However, aquaculture facilities in Japan are widely installed in coastal waters where natural disasters, such as typhoons and tsunamis, might wash these facilities away, thereby interfering with maritime navigation safety. Therefore, it is imperative to efficiently monitor the state of aquaculture facilities daily, particularly after a disaster in real time. To this end, several new space-borne L-band synthetic aperture radars (SARs) continue to be launched now and in the future, whose utilizations are expected to increase nationally and internationally. An example is the Japan Aerospace Exploration Agency, currently operating a SAR that can be operated day and night, and even under cloudy conditions, called ALOS-2 PALSAR-2.

Methods
Based on the above facts, this study evaluated the effect of the incidence angle of ALOS-2 PALSAR-2 HH single-polarization data, using 3 m spatial resolution, on aquaculture raft detection. As the study site, we selected Ago Bay, located on the Pacific coast of Mie Prefecture in central Japan since the Nankai Trough Megathrust Earthquake and tsunamis have been predicted to occur in the future around this area. Then, we analyzed the sigma zero (backscattering coefficient) of aquaculture rafts and their surrounding sea surfaces, including the relationships between satellite orbits and aquaculture raft directions.

Results
Investigations revealed that the optimum incidence angle for detecting aquaculture rafts in this study was 33.8°–45.1°. Differences in the sigma zero values existed between the ascending and descending orbits. However, the incidence angles differed on the orbits. Then, differences in the median sigma zero values across a range of incidence angles were evaluated under the descending orbit. In addition, when the directions of the aquaculture rafts were closely perpendicular to the satellite orbit, aquaculture rafts tended to show the highest values of sigma zero due to Bragg resonance scattering. Hence, this knowledge may allow for the rapid detection of aquaculture rafts during an emergency without going on-site.
The Influence of the Invasive Plant Taraxacum officinale (FH Wigg) on Soil Characteristics
Authors: Ezekiel Anietie G. , Umoh Omodot T. , Nwachukwu Adanma R. , Oghenekevwe Augustine O. , Uyoh Victoria E. 
Published: January 2023

The study which was aimed at detecting the effects of the properties of Taraxacum officinale on the characteristics of the soils was carried out in a garden in Use Offot Community in Uyo, Akwa Ibom state using the purposive sampling method. The samples were collected at a depth of 0-30 cm from different points in the study area, and were bulked into one composite sample. Standard procedures were adopted in the analyses of the soil sample and the results of the analysis of the sample showed that the soil with Taraxacum officinale had a neutral soil pH (7.055) as against the control soil which had a slightly acidic pH (6.72). The organic carbon, total nitrogen and available phosphorus contents were 0.78 %, 0.04 %, and 87.04 mg/kg respectively. The average cation exchange capacity (3.25 cmol/kg) was low; also the soil texture of the samples were identified as loamy sand. These values revealed that Taraxacum officinale had effects on the physicochemical properties of the soil it grew on.
Association of Nursing Home Exposure to Hurricane-Related Inundation With Emergency Preparedness
Authors: Festa Natalia , Throgmorton Kaitlin F. , Heaphy Nora , Canavan Maureen , Gill Thomas M. 
Published: January 2023

ImportanceWhether US nursing homes are well prepared for exposure to hurricane-related inundation is uncertain.ObjectivesTo estimate the prevalence of nursing homes exposed to hurricane-related inundation and evaluate whether exposed facilities are more likely to meet Centers for Medicare &amp;amp; Medicaid Services (CMS) emergency preparedness standards.Design, Setting, and ParticipantsThis cross-sectional study included CMS-certified nursing homes in Coastal Atlantic and Gulf Coast states from January 1, 2017, to December 31, 2019. The prevalence of facilities exposed to at least 2 feet of hurricane-related inundation used models from the National Hurricane Center across coastal areas overseen by 5 CMS regional offices: New England, New York metropolitan area, Mid-Atlantic region, Southeast and Eastern Gulf Coast, and Western Gulf Coast. Critical emergency preparedness deficiencies cited during CMS life safety code inspections were identified.Main Outcomes and MeasuresThe analysis used generalized estimating equations with binomial and negative binomial distributions to evaluate associations between exposure status and the presence and number of critical emergency preparedness deficiencies. Regionally stratified associations (odds ratios [ORs]) and rate ratios [RRs]) with 95% CIs, adjusted for state-level fixed effects and nursing home characteristics, were reported.ResultsOf 5914 nursing homes, 617 (10.4%) were at risk of inundation exposure, and 1763 (29.8%) had a critical emergency preparedness deficiency. Exposed facilities were less likely to be rural, were larger, and had similar CMS health inspection, quality, and staffing ratings compared with unexposed facilities. Exposure was positively associated with the presence and number of emergency preparedness deficiencies for the nursing homes within the Mid-Atlantic region (adjusted OR, 1.91 [95% CI, 1.15-3.20]; adjusted RR, 2.51 [95% CI, 1.41-4.47]). Conversely, exposure was negatively associated with the number of emergency preparedness deficiencies among facilities within the Western Gulf Coast (aRR, 0.55 [95% CI, 0.36-0.86]). The associations for the number of emergency preparedness deficiencies remained after correction for multiple comparisons.Conclusions and RelevanceThe findings of this cross-sectional study suggest that the association between exposure to hurricane-related inundation and nursing home emergency preparedness differs considerably across the Coastal Atlantic and Gulf regulatory regions. These findings further suggest that there may be opportunities to reduce regional heterogeneity and improve the alignment of nursing home emergency preparedness with surrounding environmental risks.
Guilt assessment after retracted voluntary and coerced‐compliant confessions in combination with exculpatory or ambiguous evidence
Authors: Schneider Teresa , Sauerland Melanie 
Published: January 2023

AbstractWe investigated how voluntary confessions, coerced‐compliant confessions, and no‐confessions influenced guilt assessments in combination with other exculpatory or ambiguous evidence. In three experiments (total N = 808), participants studied case information and provided guilt assessments. As expected, in Experiment 1 and 2a, (i) voluntary confessions to protect a family member elicited stronger guilt attributions than no‐confessions and (ii) ambiguous evidence led to stronger guilt attributions than exculpatory evidence. In Experiment 2b, voluntary confessions to protect a group‐member (but not to protect a family‐member) elicited stronger guilt attributions than no‐confessions. Exculpatory eyewitness evidence elicited stronger guilt attributions than exculpatory DNA evidence and participants assigned more weight to exculpatory DNA than eyewitness evidence. Participants were able to discount coerced‐compliant confessions when they received information about the interrogations (Experiments 2a/b), but did not consistently consider risk factors for (voluntary) false confessions outside the interrogation room when assessing guilt.
Baseline Glucocorticoid‐Related Toxicity Scores in Giant Cell Arteritis: A Post Hoc Analysis of the GiACTA Trial
Authors: Patel Naomi J. , Fu Xiaoqing , Zhang Yuqing , Stone John H. 
Published: January 2023

ObjectiveGiant cell arteritis (GCA) requires treatment with high‐dose, long‐term glucocorticoids (GCs). A score assessing and quantifying patients’ baseline GC‐related toxicity may be important to risk stratification and therapeutic decision‐making in patients initiating immunosuppression.MethodsWe analyzed patients with GCA enrolled in the Tocilizumab in Giant Cell Arteritis (GiACTA) trial. Baseline GC‐related toxicity scores for 12 domains were derived from the Glucocorticoid Toxicity Index using baseline medications, medical history, vital signs, and laboratory values. The 12 domains examined were body mass index, glucose tolerance, blood pressure, lipid metabolism, bone and/or tendon, GC myopathy, skin toxicity, neuropsychiatric effects, infection, ocular toxicity, gastrointestinal injury, and adrenal function. Potential scores ranged from 0 to 538. We compared differences between those with newly diagnosed versus relapsing disease at baseline.ResultsA total of 250 patients were included (75% female, mean age 69 years). The mean ± SD baseline GC‐related toxicity score among all patients was 111.3 ± 53.2. The domains that contributed most to the overall scores were blood pressure (24.0% of the overall score), followed by glucose tolerance (22.6%) and neuropsychiatric effects (15.9%). Baseline GC‐related toxicity scores were higher in patients with relapsing disease compared with those with newly diagnosed disease (mean of 122.5 vs. 98.9; P < 0.001). The body mass index and neuropsychiatric domain scores were significantly higher in patients with relapsing disease.ConclusionThis approach to the assessment of baseline GC‐related toxicity distinguished patients with relapsing GCA from those with newly diagnosed disease. Baseline GC‐related toxicity scores may be useful in therapeutic decision‐making for patients beginning immunosuppressive treatment.
CuSCN Modified Back Contacts for High Performance CZTSSe Solar Cells
Authors: Ji Yixiong , Zhao Xiangyun , Pan Yining , Su Zhenghua , Lin Jinhong , Akinoglu Eser Metin , Xu Yang , Zhang Heyou , Zhao Pengjun , Dong Yue , Wei Xingzhan , Liu Fangyang , Mulvaney Paul 
Published: January 2023

AbstractOptimization of the back contact interface is crucial for improving the performance of Cu2ZnSnS4 (CZTS) thin film solar cells. In this paper, self‐depleted CuSCN is deployed as an intermediate layer at the Mo/CZTS interface to improve the quality of the back contact. This CuSCN layer, obtained via aqueous solution processing, reduces the thickness of Mo(S,Se)2 and eliminates multi‐layer crystallization of the absorber by suppressing the undesirable reaction between Mo and Se during the selenization process. By regulating the selenium infiltration into the CZTS precursor films during the selenization process, highly crystalline, single‐layer Cu2ZnSn(S,Se)4 (CZTSSe) absorber layers are realized. The single‐layer CZTSSe absorber exhibits reduced carrier recombination, enhanced carrier density and increased work function. The improved back contact and absorber layer enables 11.1% power‐conversion‐efficiency to be achieved.
Outcomes after allogeneic hematopoietic cell transplant in patients diagnosed with blast phase of myeloproliferative neoplasms: A retrospective study from the Chronic Malignancies Working Party of the European Society for Blood and Marrow Transplantation
Authors: Ortí Guillermo , Gras Luuk , Zinger Nienke , Finazzi Maria Chiara , Sockel Katja , Robin Marie , Forcade Edouard , Avenoso Daniele , Kröger Nicolaus , Finke Jürgen , Radujkovic Aleksandar , Hunault‐Berger Mathilde , Schroyens Wilfried , Zuckerman Tsila , Bourhis Jean Henri , Chalandon Yves , Bloor Adrian , Schots Rik , de Wreede Liesbeth C. , Drozd‐Sokolowska Joana , Raj Kavita , Polverelli Nicola , Czerw Tomasz , Hernández‐Boluda Juan Carlos , McLornan Donal , Yakoub‐Agha Ibrahim 
Published: January 2023

AbstractAllogeneic hematopoietic cell transplant (allo‐HCT) provides the only potential route to long‐term remission in patients diagnosed with blast phase transformation of myeloproliferative neoplasm (BP‐MPN). We report on a large, retrospective European Society for Blood and Marrow Transplantation registry‐based study of BP‐MPN patients undergoing allo‐HCT. BP‐MPN patients undergoing first allo‐HCT between 2005 and 2019 were included. A total of 663 patients were included. With a median follow‐up of 62 months, the estimated 3‐year overall survival (OS) was 36% (95% confidence interval [CI], 32–36). Factors associated with lower OS were Karnofsky Performance Score (KPS) <90 (hazard ratio [HR] 1.65, p < .001) and active disease at allo‐HCT (HR 1.45, p < .001), whereas patients undergoing allo‐HCT more recently associated with a higher OS (HR 0.96, p = .008). In a selected patient's population, the 3‐year OS of patients undergoing allo‐HCT in complete response (CR) and with a KPS ≥90 was 60%. KPS < 90 (HR 1.4, p = .001) and active disease (HR 1.44, p = .0004) were associated with a lower progression‐free survival (PFS). Conversely, most recent allo‐HCT associated with a higher PFS (HR 0.96, p = .008). Active disease at allo‐HCT (HR 1.34, p = .03) was associated with a higher cumulative incidence of relapse (RI) and allo‐HCT in earlier calendar years (HR 0.96, p = .02) associated with a lower RI. Last, KPS < 90 (HR 1.91, p < .001), active disease (HR 1.74, p = .003) and allo‐HCT from mismatched related donors were associated with a higher non‐relapse mortality (HR 2.66, p = .003). In this large series of BP‐MPN patients, about one third were alive at 3 years after transplantation. Patients undergoing allo‐HCT in the more recent era, with a KPS ≥90 and in CR at transplant had a better prognosis.
Association of ABO mismatch with the outcomes of allogeneic hematopoietic cell transplantation for acute leukemia
Authors: Guru Murthy Guru Subramanian , Logan Brent R. , Bo‐Subait Stephanie , Beitinjaneh Amer , Devine Steven , Farhadfar Nosha , Gowda Lohith , Hashmi Shahrukh , Lazarus Hillard , Nathan Sunita , Sharma Akshay , Yared Jean A. , Stefanski Heather E. , Pulsipher Michael A. , Hsu Jack W. , Switzer Galen E. , Panch Sandhya R. , Shaw Bronwen E. 
Published: January 2023

AbstractAllogeneic hematopoietic cell transplantation (allo‐HCT) is a potentially curative treatment for acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL). While many factors influence the outcomes of allo‐HCT, the independent impact of donor–recipient ABO mismatching remains unclear. Using the Center for International Blood and Marrow Transplant Research (CIBMTR) database, we identified patients aged ≥18 years with AML or ALL who underwent allo‐HCT between 2008 and 2018. Our objectives were to analyze the outcomes of allo‐HCT based on the donor–recipient ABO status (match, minor mismatch, major mismatch, bidirectional mismatch). Among 4946 eligible patients, 2741 patients (55.4%) were ABO matched, 1030 patients (20.8%) had a minor ABO mismatch, 899 patients (18.1%) had a major ABO mismatch, and 276 patients (5.6%) had a bidirectional ABO mismatch. In multivariable analyses, compared to ABO matched allo‐HCT, the presence of a major ABO mismatch was associated with worse overall survival (HR 1.16, 95% CI 1.05–1.29; p = 0.005), inferior platelet engraftment (HR 0.83, 95% CI 0.77–0.90; p < 0.001), and higher primary graft failure (HR 1.60, 95% CI 1.12–2.30, p = 0.01). Relapse, acute graft versus host disease (GVHD) grades III‐IV and chronic GVHD were not significantly associated with ABO status. While donor age was not significantly associated with outcomes, older recipient age was associated with worse survival and non‐relapse mortality. Our study demonstrates that donor–recipient ABO status is independently associated with survival and other post‐transplantation outcomes in acute leukemia. This underscores the importance of considering the ABO status in donor selection algorithms and its impact in acute leukemia.
Sequence analyses of relapsed or refractory diffuse large B‐cell lymphomas unravel three genetic subgroups of patients and the GNA13 mutant as poor prognostic biomarker, results of LNH‐EP1 study
Authors: Michot Jean‐Marie , Quivoron Cyril , Sarkozy Clémentine , Danu Alina , Lazarovici Julien , Saleh Khalil , El‐Dakdouki Yolla , Goldschmidt Vincent , Bigenwald Camille , Dragani Matteo , Bahleda Rastislav , Baldini Capucine , Arfi‐Rouche Julia , Martin‐Romano Patricia , Tselikas Lambros , Gazzah Anas , Hollebecque Antoine , Lacroix Ludovic , Ghez David , Vergé Veronique , Marzac Christophe , Cotteret Sophie , Rahali Wassila , Soria Jean‐Charles , Massard Christophe , Bernard Olivier A. , Dartigues Peggy , Camara‐Clayette Valérie , Ribrag Vincent 
Published: January 2023

AbstractAdvances in molecular profiling of newly diagnosed diffuse large B‐cell lymphoma (DLBCL) have recently refine genetic subgroups. Genetic subgroups remain undetermined at the time of relapse or refractory (RR) disease. This study aims to decipher genetic subgroups and search for prognostic molecular biomarkers in patients with RR‐DLBCL. From 2015 to 2021, targeted next‐generation sequencing analyses of germline‐matched tumor samples and fresh tissue from RR‐DLBCL patients were performed. Unsupervised clustering of somatic mutations was performed and correlations with patient outcome were sought. A number of 120 patients with RR‐DLBCL were included in LNH‐EP1 study and a molecular tumor landscape was successfully analyzed in 87% of patients (104/120 tumor samples). The median age was 67.5 years (range 27.4–87.4), median number of previous treatments was 2 (range 1–9). The most frequently mutated genes were TP53 (n = 53 mutations; 42% of samples), CREBBP (n = 39; 32%), BCL2 (n = 86; 31%), KMT2D (n = 39; 28%) and PIM1 (n = 54; 22%). Unsupervised clustering separated three genetic subgroups entitled BST (enriched in BCL2, SOCS1, and TNFRSF14 mutations); TKS (enriched in TP53, KMT2D, and STAT6 mutations); and PCM (enriched in PIM1, CD79B, and MYD88 mutations). Median overall survival (OS) was 11.0 (95% confidence interval [CI]: 8.1–12.6) months. OS was not significantly different between the three genetic subgroups. GNA13 mutant was significantly associated with an increased risk of death (hazard ratio: 6.6 [95% CI: 2.1–20.6]; p = .0011) and shorter OS (p = .0340). At the time of relapse or refractory disease, three genetic subgroups of DLBCL patients were delineated, which could help advance precision molecular medicine programs.
Intranasal fentanyl and discharge from the emergency department among children with sickle cell disease and vaso‐occlusive pain: A multicenter pediatric emergency medicine perspective
Authors: Rees Chris A. , Brousseau David C. , Ahmad Fahd A. , Bennett Jonathan , Bhatt Seema , Bogie Amanda , Brown Kathleen M. , Casper T. Charles , Chapman Laura L. , Chumpitazi Corrie E. , Cohen Daniel M. , Dampier Carlton , Ellison Angela M. , Grasemann Hartmut , Hatabah Dunia , Hickey Robert W. , Hsu Lewis L. , Bakshi Nitya , Leibovich Sara , Patil Prabhumallikarjun , Powell Elizabeth C. , Richards Rachel , Sarnaik Syana , Weiner Debra L. , Morris Claudia R. ,   the SCD Arginine Study Group and PECARN
Published: January 2023

AbstractChildren with sickle cell disease (SCD) commonly experience vaso‐occlusive pain episodes (VOE) due to sickling of erythrocytes, which often requires care in the emergency department. Our objective was to assess the use and impact of intranasal fentanyl for the treatment of children with SCD‐VOE on discharge from the emergency department in a multicenter study. We conducted a cross‐sectional study at 20 academic pediatric emergency departments in the United States and Canada. We used logistic regression to test bivariable and multivariable associations between the outcome of discharge from the emergency department and candidate variables theoretically associated with discharge. The study included 400 patients; 215 (54%) were female. The median age was 14.6 (interquartile range 9.8, 17.6) years. Nineteen percent (n = 75) received intranasal fentanyl in the emergency department. Children who received intranasal fentanyl had nearly nine‐fold greater adjusted odds of discharge from the emergency department compared to those who did not (adjusted odds ratio 8.99, 95% CI 2.81–30.56, p < .001). The rapid onset of action and ease of delivery without intravenous access offered by intranasal fentanyl make it a feasible initial parenteral analgesic in the treatment of children with SCD presenting with VOE in the acute‐care setting. Further study is needed to determine potential causality of the association between intranasal fentanyl and discharge from the emergency department observed in this multicenter study.