bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genomic history of coastal societies from eastern South America
Authors: Ferraz Tiago , Suarez Villagran Ximena , Nägele Kathrin , Radzevičiūtė Rita , Barbosa Lemes Renan , Salazar-García Domingo C. , Wesolowski Verônica , Lopes Alves Marcony , Bastos Murilo , Rapp Py-Daniel Anne , Pinto Lima Helena , Mendes Cardoso Jéssica , Estevam Renata , Liryo Andersen , Guimarães Geovan M. , Figuti Levy , Eggers Sabine , Plens Cláudia R. , Azevedo Erler Dionne Miranda , Valadares Costa Henrique Antônio , da Silva Erler Igor , Koole Edward , Henriques Gilmar , Solari Ana , Martin Gabriela , Serafim Monteiro da Silva Sérgio Francisco , Kipnis Renato , Müller Letícia Morgana , Ferreira Mariane , Carvalho Resende Janine , Chim Eliane , da Silva Carlos Augusto , Borella Ana Claudia , Tomé Tiago , Müller Plumm Gomes Lisiane , Barros Fonseca Diego , Santos da Rosa Cassia , de Moura Saldanha João Darcy , Costa Leite Lúcio , Cunha Claudia M. S. , Viana Sibeli Aparecida , Ozorio Almeida Fernando , Klokler Daniela , Fernandes Henry Luydy Abraham , Talamo Sahra , DeBlasis Paulo , Mendonça de Souza Sheila , de Paula Moraes Claide , Elias Oliveira Rodrigo , Hünemeier Tábita , Strauss André , Posth Cosimo 
Published: July 2023

AbstractSambaqui (shellmound) societies are among the most intriguing archaeological phenomena in pre-colonial South America, extending from approximately 8,000 to 1,000 years before present (yr bp) across 3,000 km on the Atlantic coast. However, little is known about their connection to early Holocene hunter-gatherers, how this may have contributed to different historical pathways and the processes through which late Holocene ceramists came to rule the coast shortly before European contact. To contribute to our understanding of the population history of indigenous societies on the eastern coast of South America, we produced genome-wide data from 34 ancient individuals as early as 10,000 yr bp from four different regions in Brazil. Early Holocene hunter-gatherers were found to lack shared genetic drift among themselves and with later populations from eastern South America, suggesting that they derived from a common radiation and did not contribute substantially to later coastal groups. Our analyses show genetic heterogeneity among contemporaneous Sambaqui groups from the southeastern and southern Brazilian coast, contrary to the similarity expressed in the archaeological record. The complex history of intercultural contact between inland horticulturists and coastal populations becomes genetically evident during the final horizon of Sambaqui societies, from around 2,200 yr bp, corroborating evidence of cultural change.
On-chip label-free cell classification based directly on off-axis holograms and spatial-frequency-invariant deep learning
Authors: Dudaie Matan , Barnea Itay , Nissim Noga , Shaked Natan T. 
Published: July 2023

AbstractWe present a rapid label-free imaging flow cytometry and cell classification approach based directly on raw digital holograms. Off-axis holography enables real-time acquisition of cells during rapid flow. However, classification of the cells typically requires reconstruction of their quantitative phase profiles, which is time-consuming. Here, we present a new approach for label-free classification of individual cells based directly on the raw off-axis holographic images, each of which contains the complete complex wavefront (amplitude and quantitative phase profiles) of the cell. To obtain this, we built a convolutional neural network, which is invariant to the spatial frequencies and directions of the interference fringes of the off-axis holograms. We demonstrate the effectiveness of this approach using four types of cancer cells. This approach has the potential to significantly improve both speed and robustness of imaging flow cytometry, enabling real-time label-free classification of individual cells.
Enhancing catalytic activity of gold nanoparticles in a standard redox reaction by investigating the impact of AuNPs size, temperature and reductant concentrations
Authors: Bano Attia , Dawood Asadullah , Rida  , Saira Farhat , Malik Abdul , Alkholief Musaed , Ahmad Hijaz , Khan Muhammad Asad , Ahmad Zubair , Bazighifan Omar 
Published: July 2023

AbstractIn this work, the catalytic activity of three different sizes of gold nano particles (AuNPs) (12, 30, and 45 nm) synthesized by the citrate reduction process studied in the conventional redox reaction of K3Fe (CN6)−3 to K4Fe (CN6)−4 using NaBH4(reductant) at four different temperatures (5 °C, 10 °C, 15 °C, and 20 °C) and measured by UV–visible spectrophotometry. Comparative kinetic analysis of different sizes of AuNPs including rate constant, activation energy, Entropy values and Frequency of collisions are reported for the first time. Transmission electron microscopy analysis is employed to investigate morphology and particle size. Spherical nanoparticles of size 12, 30, and 45 nm were observed. The UV–visible spectra were recorded at regular intervals, and it was seen that the peak of K3Fe (CN6)−3 decreased gradually with time, at the same time surface plasmon resonance of AuNPs remained constant. As reaction catalysts, AuNPs maintain their optical density which shows their stability during the course of reaction. The kinetic parameters i.e., rate constant, and activation energy (k, t1/2, Ea) were determined for three distinct sizes of gold nanoparticles (AuNPs) using the reductant at various concentrations. The value of k increases by increasing reductant concentration. This rise was significant for the small AuNPs. Increasing gold nanoparticle size (12, 30, 45 nm) decreased rate constant. As the size of AuNPs decreased the Ea reduced as well, i.e. 17.325 k cal mol−1 for 12 nm, 19 k cal mol−1 for 30 nm and 21 k cal mol−1 for 45 nm AuNPs. For 50 mM of NaBH4, k for 45 nm AuNPs is 0.10728 s−1, but for 12 nm AuNPs, the value of k is 0.145 s−1, indicating that the 12 nm AuNPs have the greatest rate constant values. The rate of reaction rises with an increase in reductant concentration and temperature, but this increase is significant in the case of small-sized nanoparticles, i.e., 12 nm, which have a high surface area and low Ea. Besides being a model redox reaction, the reduction of K3Fe (CN6)−3 to K4Fe (CN6)−4 has industrial use in making fertilizers and paint industry, anti-coating agent in colour photography, in dot etching and in amperometric biosensors.
The comparative perspective of phytochemistry and biological properties of the Apiaceae family plants
Authors: Hamidian Mohammad , Salehi Amin , Naghiha Reza , Dehnavi Mohsen Movahhedi , Castangia Ines , Mirfathi Maryamossadat Nejad 
Published: July 2023

AbstractDespite the availability of numerous reports on the discovery of medicinal plant compounds and their properties, one may encounter contradictory results released by these reports at the level of plant families and even within species. To establish an accurate perspective of the Apiaceae family, this study examined the fruit essential oil and methanolic extract of wild and common species of this family. According to the measurement of the antioxidant property in the methanolic extract of the fruits using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) method, Ferula gummosa, Pimpinella anisum and Cuminum cyminum have high power in inhibiting free radicals. However, Bunium persicum had the strongest DPPH radicals inhibitory potential among all essential oils. The results of antimicrobial tests and their classification analysis showed that C. cyminum and B. persicum fruit essential oil with a high amount of cuminaldehyde had the most antibacterial properties. At the same time, the antifungal properties of H. persicum essential oil (rich in aliphatic ester) were stronger than those of the all the studied plants. Also, the essential oils of F. gummosa and Kelussia odoratissima had favourable antimicrobial properties compared to other studied plants. The investigation of the bacterial structure by scanning electron microscope confirmed the effect of the applied essential oils dose and their antibacterial potential. In general, for the first time, this paper determined the biological values of the fruit essential oil of some wild plants, such as K. odoratissima and H. persicum. Besides, in vitro examination and the mathematical models provided a suitable classification, which makes a comprehensive view in terms of the properties of the Apiaceae family.
Temporal relationships between BMI and obesity-related predictors of cardiometabolic and breast cancer risk in a longitudinal cohort
Authors: Xu Bin , Lv Liang , Chen Xin , Li Xingyue , Zhao Xunying , Yang Huifang , Feng Wanting , Jiang Xia , Li Jiayuan 
Published: July 2023

AbstractProspective inter-relationships among biomarkers were unexplored, which may provide mechanistic insights into diseases. We investigated the longitudinal associations of BMI change with trajectories of biomarkers related to cardiometabolic or breast cancer risk. A longitudinal study was conducted among 444 healthy women between 2019 to 2021. Cross‑lagged path analysis was used to examine the temporal relationships among BMI, cardiometabolic risk score (CRS), and obesity‑related proteins score (OPS) of breast cancer. Linear mixed-effect models were applied to investigate associations of time-varying BMI with biomarker-based risk score trajectories. Baseline BMI was associated with subsequent change of breast cancer predictors (P = 0.03), and baseline CRS were positively associated with OPS change (P < 0.001) but not vice versa. After fully adjustment of confounders, we found a 0.058 (95%CI = 0.009–0.107, P = 0.020) units increase of CRS and a 1.021 (95%CI = 0.041–1.995, P = 0.040) units increase of OPS as BMI increased 1 kg/m2 per year in postmenopausal women. OPS increased 0.784 (95%CI = 0.053–1.512, P = 0.035) units as CRS increased 1 unit per year. However, among premenopausal women, BMI only significantly affected CRS (β = 0.057, 95%CI = 0.007 to 0.107, P = 0.025). No significant change of OPS with time-varying CRS was found. Higher increase rates of BMI were associated with worse trajectories of biomarker-based risk of cardiometabolic and breast cancer. The longitudinal impact of CRS on OPS is unidirectional. Recommendations such as weight control for the reduction of cardiometabolic risk factors may benefit breast cancer prevention, especially in postmenopausal women.
Design, synthesis, in vitro, and in silico evaluations of benzo[d]imidazole-amide-1,2,3-triazole-N-arylacetamide hybrids as new antidiabetic agents targeting α-glucosidase
Authors: Yousefnejad Faeze , Mohammadi-Moghadam-Goozali Mahyar , Sayahi Mohammad Hosein , Halimi Mohammad , Moazzam Ali , Mohammadi-Khanaposhtani Maryam , Mojtabavi Somayeh , Asadi Mehdi , Faramarzi Mohammad Ali , Larijani Bagher , Amanlou Massoud , Mahdavi Mohammad 
Published: July 2023

Abstractα-Glucosidase as a carbohydrate-hydrolase enzyme is a crucial therapeutic target for type 2 diabetes. In this work, benzo[d]imidazole-amide containing 1,2,3-triazole-N-arylacetamide derivatives 8a–n were synthesized and evaluated for their inhibitory activity against α-glucosidase. In vitro α-glucosidase inhibition assay demonstrated that more than half of the title compounds with IC50 values in the range of 49.0–668.5 μM were more potent than standard inhibitor acarbose (IC50 = 750.0 µM). The most promising inhibitor was N-2-methylphenylacetamid derivative 8c. Kinetic study revealed that compound 8c (Ki = 40.0 µM) is a competitive inhibitor against α-glucosidase. Significantly, molecular docking and molecular dynamics studies on the most potent compound showed that this compound with a proper binding energy interacted with important amino acids of the α-glucosidase active site. Study on cytotoxicity of the most potent compounds 8c, 8e, and 8g demonstrated that these compounds did not show cytotoxic activity against the cancer and normal cell lines MCF-7 and HDF, respectively. Furthermore, the ADMET study predicted that compound 8c is likely to be orally active and non-cytotoxic.
Failure characteristics and conditions of rock-coal combination structure with weak layer under dynamic and static stresses
Authors: Fan Yufeng , Xiao Xiaochun , Xu Jun , Ding Xin , Wang Aiwen , Wang Beifang , Lei Yun 
Published: July 2023

AbstractTo comprehensively understand the mechanical response of a rock-coal combination structure containing a weak layer, a series of laboratory static loading and impact loading experiments were conducted. The results showed that under static load, the sliding process of the rock coal structure was relatively slow, and fragments can be observed. Under the action of horizontal impact loading, the whole coal stratum slipped out rapidly, and the process lasted only 0.05 s. Under the horizontal and axial impact loads, the coal stratum remained stable first, and then it slipped out as a whole under the action of static load. Additionally, a sliding instability criterion of a rock coal structure containing a weak layer was established based on theoretical analysis. The key parameter P value was checked through a numerical simulation experiment. It was found that the value was linearly related to the mechanical properties of the weak layer and overburden stress, and the experimental results coincided with the theoretical results. Finally, the relationship between sliding rockburst and strain rockburst was discussed, and these results can provide an important scientific basis for the prevention and control of dynamic disasters in deep mining.
A diverse ancestrally-matched reference panel increases genotype imputation accuracy in a underrepresented population
Authors: Mauleekoonphairoj John , Tongsima Sissades , Khongphatthanayothin Apichai , Jurgens Sean J. , Zimmerman Dominic S. , Sutjaporn Boosamas , Wandee Pharawee , Bezzina Connie R. , Nademanee Koonlawee , Poovorawan Yong 
Published: July 2023

AbstractVariant imputation, a common practice in genome-wide association studies, relies on reference panels to infer unobserved genotypes. Multiple public reference panels are currently available with variations in size, sequencing depth, and represented populations. Currently, limited data exist regarding the performance of public reference panels when used in an imputation of populations underrepresented in the reference panel. Here, we compare the performance of various public reference panels: 1000 Genomes Project, Haplotype Reference Consortium, GenomeAsia 100 K, and the recent Trans-Omics for Precision Medicine (TOPMed) program, when used in an imputation of samples from the Thai population. Genotype yields were assessed, and imputation accuracies were examined by comparison with high-depth whole genome sequencing data of the same sample. We found that imputation using the TOPMed panel yielded the largest number of variants (~ 271 million). Despite being the smallest in size, GenomeAsia 100 K achieved the best imputation accuracy with a median genotype concordance rate of 0.97. For rare variants, GenomeAsia 100 K also offered the best accuracy, although rare variants were less accurately imputable than common variants (30.3% reduction in concordance rates). The high accuracy observed when using GenomeAsia 100 K is likely attributable to the diverse representation of populations genetically similar to the study cohort emphasizing the benefits of sequencing populations classically underrepresented in human genomics.
Serum and supplemental vitamin D levels and insulin resistance in T2DM populations: a meta-analysis and systematic review
Authors: Lei Xingxing , Zhou Qian , Wang Yanmei , Fu Shunlian , Li Zinan , Chen Qiu 
Published: July 2023

AbstractObservational studies have shown a negative correlation between Vitamin D level and the likelihood of developing insulin resistance (IR) and/or diabetes over time, yet evidence remains inconsistent. In this meta-analysis and systematic review, we strive to define the potential association between serum or supplemental Vitamin D Levels and insulin resistance respectively, as well as the contribution of Vitamin D to type 2 diabetes, and to summarize the biologic plausibility of Vitamin D. Four databases (PubMed, Embase, Cochrane Library, and Web of Science) were searched for this Systematic Literature Review (SLR) to find appropriate observational studies and clinical trials published in English through to July 2022. EndNote (version X9) is used to manage the literature search results. We calculated Standard Mean Differences (SMDs) and Risk Ratios (RRs) with their 95% Confidence Intervals (CIs), separately, for continuous and dichotomous outcomes. The correlation coefficients were normalized to z values through Fisher’s z-transformation to calculate the relevant statistics. Meta-analyses were carried out for all comparisons, based on a random-effects pooling model. Data analysis was performed using RevMan (version 5.3) and STATA (version 15.1). All statistical tests were two-sided, with P < 0.05 were regarded as significant. In our current meta-analysis, there are 18 RCTs and 20 observational studies including 1243 and 11,063 participants respectively. In the overall analysis, the diabetic with Vitamin D supplement treatment group showed significantly improve serum insulin (SMD =  − 0.265, 95% CI − 0.394 to − 0.136, P < 0.05), glucose (SMD =  − 0.17, 95% CI − 0.301to − 0.039, P < 0.05) and HOMA-IR (SMD =  − 0.441, 95% CI − 0.582 to − 0.3, P < 0.05) compared with the routine treatment group. Correlation analysis results showed that all three outcomes were significantly correlated in a negative manner with raised Vitamin D (insulin: r =  − 0.08 95% =  − 0.12 to − 0.04; glucose: r =  − 0.06 95% =  − 0.11 to − 0.01; HOMA-IR: r =  − 0.08 95% =  − 0.09 to − 0.06). Results of overall analysis proved that vitamin D has shown significant effect on regulates insulin resistance, and there is a significant inverse association between serum Vitamin D level and IR. Vitamin D supplementation is expected to be integrated into conventional medical approaches to prevent type 2 diabetes and to mitigate the burden of diabetes for individuals and society.PROSPERO registration number: CRD42022348295.
Two optimized novel potential formulas and numerical algorithms for $$m\times n$$ cobweb and fan resistor networks
Authors: Zhao Wenjie , Zheng Yanpeng , Jiang Xiaoyu , Jiang Zhaolin 
Published: July 2023

AbstractThe research of resistive network will become the basis of many fields. At present, many exact potential formulas of some complex resistor networks have been obtained. Computer numerical simulation is the trend of computing, but written calculation will limit the time and scale. In this paper, the potential formulas of a $$m\times n$$

m
×
n

scale cobweb resistor network and fan resistor network are optimized. Chebyshev polynomial of the second class and the absolute value function are used to express the novel potential formulas of the resistor network, and described in detail the derivation process of the explicit formula. Considering the influence of parameters on the potential formulas, several idiosyncratic potential formulas are proposed, and the corresponding three-dimensional dynamic images are drawn. Two numerical algorithms of the computing potential are presented by using the mathematical model and DST-VI. Finally, the efficiency of calculating potential by different methods are compared. The advantages of new potential formulas and numerical algorithms by the calculation efficiency of the three methods are shown. The optimized potential formulas and the presented numerical algorithms provide a powerful tool for the field of science and engineering.
Myocardial deformation imaging by 2D speckle tracking echocardiography for assessment of diastolic dysfunction in murine cardiopathology
Authors: Daniels L. J. , Macindoe C. , Koutsifeli P. , Annandale M. , James S. L. , Watson L. E. , Coffey S. , Raaijmakers A. J. A. , Weeks K. L. , Bell J. R. , Janssens J. V. , Curl C. L. , Delbridge L. M. D. , Mellor Kimberley M. 
Published: July 2023

AbstractDiastolic dysfunction is increasingly identified as a key, early onset subclinical condition characterizing cardiopathologies of rising prevalence, including diabetic heart disease and heart failure with preserved ejection fraction (HFpEF). Diastolic dysfunction characterization has important prognostic value in management of disease outcomes. Validated tools for in vivo monitoring of diastolic function in rodent models of diabetes are required for progress in pre-clinical cardiology studies. 2D speckle tracking echocardiography has emerged as a powerful tool for evaluating cardiac wall deformation throughout the cardiac cycle. The aim of this study was to examine the applicability of 2D speckle tracking echocardiography for comprehensive global and regional assessment of diastolic function in a pre-clinical murine model of cardio-metabolic disease. Type 2 diabetes (T2D) was induced in C57Bl/6 male mice using a high fat high sugar dietary intervention for 20 weeks. Significant impairment in left ventricle peak diastolic strain rate was evident in longitudinal, radial and circumferential planes in T2D mice. Peak diastolic velocity was similarly impaired in the longitudinal and radial planes. Regional analysis of longitudinal peak diastolic strain rate revealed that the anterior free left ventricular wall is particularly susceptible to T2D-induced diastolic dysfunction. These findings provide a significant advance on characterization of diastolic dysfunction in a pre-clinical mouse model of cardiopathology and offer a comprehensive suite of benchmark values for future pre-clinical cardiology studies.
Kaempferol-loaded bioactive glass-based scaffold for bone tissue engineering: in vitro and in vivo evaluation
Authors: Ranjbar Faezeh Esmaeili , Farzad-Mohajeri Saeed , Samani Saeed , Saremi Jamileh , Khademi Rahele , Dehghan Mohammad Mehdi , Azami Mahmoud 
Published: July 2023

AbstractDue to the increasing prevalence of bone disorders among people especially in average age, the future of treatments for osseous abnormalities has been illuminated by scaffold-based bone tissue engineering. In this study, in vitro and in vivo properties of 58S bioactive glass-based scaffolds for bone tissue engineering (bare (B.SC), Zein-coated (C.SC), and Zein-coated containing Kaempferol (KC.SC)) were evaluated. This is a follow-up study on our previously published paper, where we synthesized 58S bioactive glass-based scaffolds coated with Kaempferol-loaded Zein biopolymer, and characterized from mostly engineering points of view to find the optimum composition. For this aim, in vitro assessments were done to evaluate the osteogenic capacity and biological features of the scaffolds. In the in vivo section, all types of scaffolds with/without bone marrow-derived stem cells (BMSC) were implanted into rat calvaria bone defects, and potential of bone healing was assessed using imaging, staining, and histomorphometric analyses. It was shown that, Zein-coating covered surface cracks leading to better mechanical properties without negative effect on bioactivity and cell attachment. Also, BMSC differentiation proved that the presence of Kaempferol caused higher calcium deposition, increased alkaline phosphatase activity, bone-specific gene upregulation in vitro. Further, in vivo study confirmed positive effect of BMSC-loaded KC.SC on significant new bone formation resulting in complete bone regeneration. Combining physical properties of coated scaffolds with the osteogenic effect of Kaempferol and BMSCs could represent a new strategy for bone regeneration and provide a more effective approach to repairing critical-sized bone defects.