bluuebunny/crossref_metadata_2025_split huggingface dataset:
A gamepad-like nucleic acid testing device for rapid detection of SARS-CoV-2 via visible nested RPA amplification
Authors: Bai Jingwei , Liu Ce , Lin Baobao , Yuan Guohua , Geng Zhi , Zhao Zhe , Wang Jiacheng , Shao Jingyu , Wang Zhenqi , Xu Yang , Yang Xujuan , Liu Chang , Feng Yingmei , Fan Xin , Wang Jing , Ren Lili , Xiao Yan , Wang Conghui , Shen Guang , Yang Yi , Zhao Chao , Li Yinqing , Liu Peng 
Published: August 2023

Abstract

Nucleic acid tests are essential for the accurate diagnosis and control of infectious diseases. However, current assays are not easily scalable for a large population, due to the requirement of laboratory settings or special equipment. Here, we developed an integrated box for instant nucleic acid screening (BINAS) which fully integrates nucleic acid release, amplification, and results visualization for self-service standalone test. Importantly, operation of BINAS runs on a novel gamepad-like interface, which allows deployment of BINAS in home settings and operation by users without any prior professional training. Performance of BINAS is empowered by a RNA extraction-free sample inactivation process and a newly developed Nest-RPA chemistry and exhibits sensitivity comparable to RT-qPCR with high specificity for SARS-Cov-2 RNA in a reaction time of 30 minutes directly from fresh swab sample to results. These innovations make BINAS a novel platform for a convenient, accurate, and deployable point-of-care testing scheme.
Low 210Pb background groundwater discharge still need to be considered for small-scale bay: a case study of Dongshan Bay
Authors: Zhou Wenqing , Wang Hao , Zhong Qiangqiang , Shao Yi , Zhou Da , Yu Xueqing 
Published: August 2023

Abstract
Groundwater quality is receiving more and more attention due to the increasing human-impact on earth environment. Due to theirs extremely toxic chemical properties, the 210Po and 210Pb activities in drinking groundwater are needed to be monitored, besides some previous studies have reported extremely high levels of natural 210Po (up to 10,000 Bq/m3), 226Ra and 222Rn isotopes. This study aims to evaluate the groundwater quality of a typical agricultural-industrial bay (Dongshan Bay) in the Taiwan Strait from radiological point of view and provide background data of naturally occurring radionuclides (226Ra and its daughter nuclides) before the construction of Zhangzhou Nuclear Power Plant, and further to discuss the relationships between 226Ra and its daughter radionuclides (222Rn, 210Pb and 210Po) and their geochemical behaviors in groundwater environment of this important coastal zone of Taiwan Strait. 210Po, 210Pb, 222Rn and 226Ra activities in 12 selected wells surrounding the bay were measured and theirs activities ranged from 0.09 ± 0.01 to 1.09 ± 0.14 Bq/m3, from 0.41 ± 0.03 to 6.28 ± 0.25 Bq/m3 and from 1180 ± 530 to 177000 ± 2200 Bq/m3, and from 2.43±0.28 to 93.7±0.9 Bq/m3, respectively. No abnormally high 210Po and 210Pb activities were detected for the investigated 12 wells surrounding the Dongshan Bay. The evaluated results show that the potential radiation doses of 226Ra and its daughters are much lower than the recommended reference dose level (RDL) of 200-800 μSv/a. Strong positive correlations between 210Pb and 210Po and between 222Rn and 210Pb activities were observed in the Dongshan Bay coastal zone groundwater, which indicates that the origins of 210Pb and 210Po in groundwater are strongly controlled by decay of the parent radionuclides 222Rn and 210Pb, respectively. We observed large deficiencies of 210Po relative to 210Pb and 210Pb relative to 222Rn occurred in the Dongshan Bay coastal zone groundwaters, which supported that 210Po and 210Pb were strongly scavenged due to their geochemical properties (particle affinity) in the groundwater-aquifer system. Among all relevant water bodies (river water, groundwater, seawater, and rainwater) in Dongshan Bay, the activity concentrations of 210Pb and 210Po in groundwater were the highest except for rainwater. However, submarine groundwater discharge (SGD) is a possible pathway that transfer radionuclides (like 210Pb) from land to nearshore marine environment. By constraining all the 210Pb’s sources in Dongshan Bay, we found groundwater discharge was the most important 210Pb source in this bay during dry season (December, 2020). Therefore, no matter in normal state or nuclear accident emergency state, more attention should be paid to the groundwater discharge of radionuclides into the ocean.
Underreporting of implementation strategies and barriers in physical activity interventions for young people at risk of problematic substance use: A brief report
Authors: Klamert Lisa , Craike Melinda , Bedi Gillinder , Kidd Susan , Pascoe Michaela , Parker Alexandra 
Published: August 2023

Abstract

Background: Several studies have assessed whether physical activity interventions can reduce substance use in young people at risk of problematic substance use. This report identifies and describes the reporting of implementation characteristics within published studies of physical activity interventions for young people at risk of problematic substance use and provides recommendations for future reporting.
Methods: Reported implementation strategies (including intervention manualization), barriers, implementation fidelity, and personnel acceptance were extracted from studies of physical activity interventions for young people aged 12-15 years at risk of problematic substance use that were included in a previous systematic review of intervention efficacy.
Results: Implementation strategies were reported in less than half of the included studies (42.9%), implementation barriers in only 10.7% of studies, intervention fidelity in 21.4%, and personnel acceptance in a single study (3.6%).
Conclusions: Results indicate insufficient reporting of implementation strategies, barriers, fidelity, and personnel acceptance. Consideration of implementation characteristics is essential for implementing physical activity interventions in practice. Inadequate or limited reporting of these characteristics may contribute to delayed uptake and adoption of evidence-based interventions in clinical practice. Recommendations to improve reporting of implementation information include: integrating standards for reporting implementation characteristics into existing reporting guidelines, developing an international taxonomy of implementation strategies, and upskilling intervention researchers in the fundamentals of implementation science.
Cost-utility analysis of azithromycin to assist in the prevention of acute cesarean section infection in a Chinese population
Authors: Liu Maobai , You Caicong , Zhang Jiahao , Lei Iianying , Zeng Xiaoling , Chen Ling , Li Na 
Published: August 2023

Abstract
OBJECTIVE
The infection rate of cesarean delivery in China is 7 to 20 times higher than that of vaginal delivery, and the infection rate of nonelective cesarean delivery may be even higher. Therefore, this study aimed to conduct a cost-utility analysis of cefazolin combined with azithromycin versus cefazolin alone for the prevention of nonelective cesarean infection from a society-wide perspective in China, taking into account maternal outcomes of current cesarean deliveries as well as potential pregnancies.
METHODS
A decision tree model was constructed using TreeAge Pro 2022 to simulate the total cost and lifetime health outcomes of pregnant women in China under two infection prophylaxis regimens. Epidemiological, quality-of-life and cost parameters were obtained from various sources, including published literature, publicly available documents from the Fujian Provincial Bureau of Medical Security, data from www.yaozh.com, and information from the China Bureau of Statistics. The discount rate has been established at 5% annually. The acceptable cost-utility threshold was established at three times China's GDP per capita in 2022.
RESULTS
An analysis of 800,000 nonelective cesarean deliveries during labor or after rupture of membranes in China estimated that the use of cefazolin combined with azithromycin reduced the incidence of endometritis by 18,400 cases, wound infections by 33,500 cases, sepsis by 24 cases, prevented a rupture of the uterus by 342 cases, hysterectomy by 24 cases, and maternal deaths by 3 cases, compared to the use of cefazolin prophylaxis alone. The baseline analysis indicates that the combination of cefazolin and azithromycin resulted in an increase of 0.00157 quality-adjusted life years and a cost reduction of $769.14, making it the superior regimen. The results of the sensitivity analysis confirmed the robustness of the baseline analysis.
Conclusion
The prophylactic use of cefazolin combined with azithromycin may result in better cost-effectiveness and health outcomes than cefazolin alone for Chinese pregnant women undergoing nonelective cesarean delivery.
Efficient Population-based Colorectal Cancer Screening in Shenzhen: A Microsimulation Modelling study
Authors: Zhu Minmin , Zhong Xuan , Liao Tong , Peng Xiaolin , Lei Lin , Peng Ji , Cao Yong 
Published: August 2023

Abstract
Background
Colorectal cancer (CRC) is a global health issue with noticeable high incidence and mortality. Microsimulation models offer a time-efficient method to dynamically analyze multiply intervention strategies. The study aimed to identify the efficient population-based CRC screening strategies for Shenzhen city.
Methods
A microsimulation model named CMOST was used to simulate CRC screening among one million population without migration in Shenzhen, with two CRC developing pathways and participation rates in real world. Questionnaire-based risk assessment models, fecal immunochemical test (FIT), and Risk-stratification model (RS model) as initial screening were simulated, followed by diagnostic colonoscopy. Several start-ages (40, 45, 50 years), stop-ages (70, 75, 80 years), and intervals (annal, biennial, triennial) for each screening strategy were assessed. The efficiency of CRC screening was analyzed by Data Envelopment Analysis method.
Results
The screening strategies reduced CRC incidence by 14–27 cases (30.1–58.4%) and mortality by 11–21 deaths (33.1–63.0%), yielded 121–283 life-years gained (LYG), while required 860 to 5868 colonoscopies per 1000 individual. Among the total of 135 screening strategies, 23 were estimated efficient. Most of the efficient screening strategies were those starting at age 40 years (17 out of 23 strategies) and stopping at age 70 (also 17 out of 23 strategies). The estimated efficiency ratios of efficient screening starting at age 40 were closed to those starting at age 45 and the estimated increase in LYG from extending screening beyond age 70 years was small in comparison with the increase in colonoscopies. The efficiency ratios increased with shorter intervals. For triennial screening from age 40 to 70, the colonoscopies per LYG increased progressively for FIT (6.7), Asia Pacific Colorectal Screening score (8.3) and RS model (13.8).
Conclusion
This study suggests that CRC screening performs from ages 40 to 70 years for average risk population in Shenzhen, and triennial FIT is an optimal strategy.
Mobile learning facilitates health schools’ students’ information and learning needs
Authors: AlMuhaissen Suha , Hamad Faten , Urquhart Christine , Tarawneh Ruba Tahsin , Asaad Muzdalifa , Abu-Ajamieh Mays 
Published: August 2023

Abstract

Purpose;The aim of this research was to investigate the attitudes towards m-learning among medical students in Jordan, and their perceptions about the advantages and disadvantages of m-learning compared to the status quo (mostly face-to-face learning). It also aimed at exploring how m-learning might support information and learning needs during clinical placements in Jordan.Methodology;This research used the quantitative research design. Data were collected using a web-based cross-sectional descriptive questionnaire using Google forms. The questionnaire was administered to 703 students from the five medical schools at the University of Jordan and 690 students completed the questionnaire (response rate of 98.2%).Findings;Students confirmed that they use mobile devices to support their learning, mainly using their smartphones. Their use of mobile devices for learning was not well advanced, and most preferred face to face learning. There were some differences among the groups of health students, indicating that m-learning habits vary according to existing teaching methods, the type of content required and the particular benefits that m-learning might offer. Also, medicine students appeared to have more diverse information needs and use mobile devices for a variety of learning related activities. Policymakers and educators need to plan carefully and take an organizational approach to ensure that m-learning complements face-to-face learning, effectively and efficiently. Students and staff should be involved in the design of interactive mobile learning materials and tools.Originality;n Jordan, Medical education in the University remains traditional, with lecture-based learning supplemented by labs and simulation tools. Several research studies have used technology acceptance models, including, variously, TAM, UTAUT, and TRA (Theory of Reasoned Action) to investigate the factors affecting intentions to use m-learning among higher education students, however, there was no detailed study of medical students’ attitudes exists.Practical implication; The results of this research will help policymakers and educators plan infrastructure and curricula for medical education in Jordan, using m-learning to meet the needs of an increased student cohort.
Study and design of corrugated cardboard trays with micro-waves by Experimental Analysis (EA) and Finite Element Methods (FEM)
Authors: Russo Franco Maria Di , Desole Maria Pia , Gisario Annamaria , Aversa Clizia , Barletta Massimiliano 
Published: August 2023

Abstract
The purpose of the work is to study by experimental analysis and finite element methods the mechanical response of a packaging, consisting of a corrugated cardboard container, used for the transport of fruit and vegetables. During the container design, three different configurations were selected which differ both in the choice of liner and in the type of wave. In particular, the type E, F and N microwaves were chosen. They are characterized by a lower amplitude than the high and medium waves commonly used in corrugated cardboard packaging, making it possible to reduce material consumption and, consequently, costs. In the initial phase of the study, experimental tests were performed to evaluate the mechanical strength of the liners. In addition, Edge Compression Tests (ECT) were performed to determine the stacking resistance of the structure. The break-in resistance of the structures was analyzed using a test conducted according to an internal standard, called Strength Packaging Test (SPT). Subsequently, a parametric study was set up with the finite element method for the simulation of the mechanical behavior of the three structures, using the homogenization technique. The comparison between the maximum total deformations, measured experimentally and calculated numerically, has highlighted the need to introduce corrective coefficients to improve the homogenization of the wave structure. In this way, it was possible to improve the matching of the results obtained on the structures simulated by the homogenization technique and those obtained on the corresponding real structures.
Systematic optimization of culture conditions and evaluation of in vitro Circulating tumor cell clusters
Authors: Chen Wenxing , Zou Jueyao , Chen Qiong , Pan Yanhong , He Yong , Zhao Han , Yang Gejun , Wei Zhonghong , Yu Suyun , Zhao Yang , Lu Yin 
Published: August 2023

Abstract
Circulating tumor cell (CTC) clusters runs a critical role in carcinoma metastasis. However, the rarity of CTC clusters and the limitations of capture techniques have blocked research progress. In vitro CTC clusters model can help us further understand the biological properties of CTC clusters and their clinical significance. It is worth noting that the biological variability of in vitro CTC clusters model due to different culture conditions has a non-negligible impact on the experimental results. Therefore, it is necessary to examine the biological similarity of in vitro CTC cluster models with clinical CTC clusters. Here, we optimized the culture method for the in vitro CTC cluster model based on the physiological environment of CTC in the circulatory system, and more importantly, we emphasized the importance of evaluating the in vitro CTC cluster models with reference to the biological characteristics of reported real CTC clusters, and assessed the similarity of the in vitro CTC clusters model, providing a reliable method for the study of CTC clusters.
Innovative surgical techniques of scleral buckling: scleral buckling with wide-angled endoillumination and intraocular irrigation assisted subretinal fluid drainage for Rhegmatogenous retinal detachment
Authors: Zhou Jinqiong , Li Qian , Zhang Xifang , Teng Teng , Lu Zixing , Tian Bei 
Published: August 2023

Abstract
Background: Scleral buckling surgery is still the preferred treatment option for some cases. However, there are still some deficiencies in its illuminating system and surgical procedures, especially for cases of children or adolescents with sticky vitreous accompanied by amount of subretinal fluid accumulation or large retinal tears, as well as cases with intraocular lens implantation or cases where the pupil should not be dilated during surgery. This study aimed to evaluate the modified surgical technique and outcomes of wide-angled endoillumination-assisted scleral buckling (SB) with intraocular irrigation during the procedure of subretinal fluid drainage for rhegmatogenous retinal detachment(RRDs).
Methods: A series of 9 eyes of 9 consecutive patients with RRD who underwent the modified SB were included in this study. SB was performed under the wild-field noncontact lens attachend to lumera microcopewith a 25-gauge endoillumination probe. Intraocular irrigation was performed under an supranormal intraocular pressure to facilitates the external drainage of subretinal fluid under the direct visualization until complete retinal reattachment.
Results: 8 patients underwent successful primary retinal detachment repair without any intraoperative or post-operative complications. In the other case, although the retina was reattached after the first operation, the retinal hole valve was further pulled due to the vitreous continuous contraction. One month after the operation, the retinal hole opened again, and retinal detachment progressed. Vitrectomy was performed.
Conclusions: Wide-angled endoillumination and intraocular irrigation assisted scleral buckling surgery for RRDs, can provide good anatomical and functional outcomes with great advantages and low complication rate.
Energy Efficient Photonic Memory Based on Electrically Programmable Embedded III-V/Si Memristors: Switches and Filters
Authors: Cheung Stanley , Tossoun Bassem , Yuan Yuan , Peng Yiwei , Hu Yingtao , Kurczveil Geza , Liang Di , Beausoleil Ray 
Published: August 2023

Abstract
We demonstrate non-volatile optical functionality by embedding multi-layer HfO2/Al2O3 memristors with III-V/Si photonics. The wafer-bonded III-V/Si memristor facilitates non-volatile optical functionality for a variety of devices such as Mach-Zehnder Interferometers (MZIs), and (de-)interleaver filters. The MZI optical memristor exhibits non-volatile optical phase shifts > π (ΔngIII-V/Si = 2.70 × 10-3) with ~ 30 dB extinction ratio while consuming 0 electrical power consumption in a true “set-and-forget” operation. We demonstrate 6 non-volatile states with each state capable of 4 Gbps modulation. III-V/Si (de-)interleavers were also demonstrated to exhibit memristive non-volatile passband transformation with full set/reset states. Time duration tests were performed on all devices and indicated non-volatility up to 24 hours and most likely beyond. To the best of our knowledge, we have demonstrated for the first time, non-volatile III-V/Si optical memristors with the largest electric-field driven phase shifts and reconfigurable filters with the lowest power consumption.
Estimating Gravitational Redshift in Galaxy Clusters and Voids Using Hernquist and Tophat Density Profiles
Authors: Wekesa Sheillah Nekesa , Wamalwa Dismas Simiyu 
Published: August 2023

Abstract
Cosmic voids happen to occupy most under dense regions of the universe. They can, therefore, be used to test our theories of structure formation and cosmology. By assuming a density profile and using it to obtain the gravitational potential, the gravitational redshift is computed.The effect is compared in two profiles of clusters and voids. From the computations, the gravitational redshift in clusters is higher than that in voids, implying that if the effect is to be considered in voids, a larger survey is required. The radii used are 20Mpc and 1Mpc for voids and clusters respectively.
Keywords: gravitational redshift, hernquist, tophat, voids, clusters, galaxies
Towards one health for dog-mediated human rabies elimination in Bangladesh: Achieving zero by 30
Authors: Ghosh Sumon , Hasan Mohammad , Nath Nirmalendu , Haider Najmul , Jones Daleniece Higgins , Islam Md. , Rahaman M. Mujibur , Mursalin Hasan , Mahmud Nadim , Kamruzzaman Md. , Rabby Md. Fazlay , Kar Shotabdi , Ullah Sayed Mohammed , Shah Md. Rashed , Jahan Afsana , Rana Md. Sohel , Chowdhury Sukanta , Uddin Md. Jamal , Sunil Thankam , Ahmed Be-Nazir , Siddiqui Umme , Kaisar S. M. Golam , Islam Md. Nazmul 
Published: August 2023

Abstract
Background: Bangladesh is making progress toward achieving zero human dog-mediated rabies deaths by 2030, a global goal set in 2015.
Methods: Drawing from multiple datasets, including patient immunization record books and mass dog vaccination (MDV) databases, we conducted a comprehensive analysis between the years 2011 to 2023 to understand the effectiveness of rabies control programmes and predict human rabies cases in Bangladesh by 2030 using time-series forecasting models. We also compared rabies virus sequences in Bangladesh and other South Asian countries from GenBank.
Findings: The human-to-dog ratio in Bangladesh was 85.83 (95% CI 74.63, 97.03), with an average dog population density of 11.51 dogs/km2 (95% CI 10.09, 12.92). The mass dog vaccination (MDV) campaign has resulted in the vaccination of 81.46% (95% CI: 80.54-82.37) of the estimated 3,030,662 dogs in the country. A decreasing trend from predicted and observed human rabies cases was identified, and it is projected that Bangladesh will have zero human rabies cases by 2030 if the current trend persists. The phylogenetic analysis shows that rabies viruses in Bangladesh belong to the Arctic-like-1 group, which differs from those in Bhutan despite sharing a common ancestor.
Interpretation: Bangladesh's One Health approach demonstrated that an increase in MDV and ARV resulted in a decline in the relative risk of human rabies cases, indicating that eliminating dog-mediated human rabies could be achievable.