bluuebunny/crossref_metadata_2025_split huggingface dataset:
Editorial: similar risk of hepatocellular carcinoma in chronic hepatitis B patients treated with tenofovir or entecavir—new clues from Europe. Authors' reply
Authors: Pol Stanislas , Luzivika Nzinga Clovis , Fontaine Hélène , Carrat Fabrice ,   the French ANRS CO22 Hepather cohort
Published: September 2023

LINKED CONTENTThis article is linked to Pol et al and Lampertico & Papatheodoridis papers. To view these articles, visit https://doi.org/10.1111/apt.16197 and https://doi.org/10.1111/apt.16238
Editorial: proton pump inhibitor use in cirrhosis—a piece of the puzzle. Authors' reply
Authors: Rocco Alba , Compare Debora , Sgamato Costantino , Coccoli Pietro , Nardone Gerardo 
Published: September 2023

LINKED CONTENTThis article is linked to Rocco et al and Celsa & Cammà papers. To view these articles, visit https://doi.org/10.1111/apt.16239 and https://doi.org/10.1111/apt.16250
Editorial: time trends in colectomy rates for ulcerative colitis in England—mixed methods brings mixed messages? Authors' reply
Authors: Worley Guy , Faiz Omar 
Published: September 2023

LINKED CONTENTThis article is linked to Worley et al and Bodger papers. To view these articles, visit https://doi.org/10.1111/apt.16202 and https://doi.org/10.1111/apt.16243
Incremental value of HBcrAg to classify 1582 HBeAg‐negative individuals in chronic infection without liver disease or hepatitis
Authors: Brunetto Maurizia R. , Carey Ivana , Maasoumy Benjamin , Marcos‐Fosch Cristina , Boonstra André , Caviglia Gian Paolo , Loglio Alessandro , Cavallone Daniela , Scholtes Caroline , Ricco Gabriele , Smedile Antonina , Riveiro‐Barciela Mar , van Bömmel Florian , van der Eijk Annemiek , Zoulim Fabien , Berg Thomas , Cornberg Markus , Lampertico Pietro , Agarwal Kosh , Buti Maria 
Published: September 2023

SummaryBackgroundAn accurate, single‐point differential diagnosis between HBeAg‐negative infection (ENI) and chronic hepatitis B (CHB) is an unmet need.AimsTo assess the diagnostic value of the new hepatitis B core‐related antigen (HBcrAg) assay.MethodsA retrospective anonymised data analysis was performed in a multicentre European (nine centres and six countries) cohort of 1582 consecutive HBsAg‐positive/HBeAg‐negative subjects classified according to EASL guidelines as: 550‐CHB, 710‐ENI and 322‐GZ (grey‐zone, HBV‐DNA <20 000 IU/mL).ResultsMean age was 44 (±13.2 y), 59% were men; HBV genotypes were 15% A, 2% B, 2% C, 45% D, 9% E, 1% F and 26% unknown. Median HBV‐DNA serum levels were 2.2 (1.5‐2.7), 3.5 (3.2‐3.8) and 5.6 (4.8‐6.6) logIU/mL in ENI, GZ and CHB, P < 0.0001. HBsAg serum levels (HBsAgsl) were comparable in CHB and GZ, but lower in ENI (2.9 [2.1‐3.6] logIU/mL), P < 0.0001. HBcrAg serum levels (HBcrAgsl) were <3 logU/mL in 90.7% (644/710) ENI, 75.2% (242/322) GZ and 4.7% (26/550) CHB (P < 0.0001). Median HBcrAgsl were 4.8 (3.9‐5.7), 2.5 (2.0‐2.9) and 2.0 (2.0‐2.5) logU/mL in CHB, GZ and ENI, (P < 0.0001). ROC‐AUCs for HBcrAg and HBsAg were 0.968 (95% CI, 0.958‐0.977) and 0.732 (95% CI, 0.704‐0.760) respectively. The optimal HBcrAgsl cut‐off to distinguish CHB from ENI was 3.14 logU/mL (95% CI, 3.02‐3.25, 91% SE, 93% SP and 92.4% DA). HBcrAgsl were associated with HBV genotypes (P < 0.001, one‐way ANOVA) but using genotype‐specific cut‐offs, HBcrAg DA remained unchanged with overlapping 95% CI.ConclusionThe HBcrAg assay showed high diagnostic performance in the accurate single‐point identification of patients with HBeAg‐negative CHB, independently of HBV genotype. This should prompt future prospective studies to confirm its diagnostic role in clinical practice.
Tranexamic acid for acute gastrointestinal bleeding: updated after the HALT‐IT trial
Authors: Chang Chun‐Yu , Huang Huai‐Kuan , Chen Yu‐Long , Wu Meng‐Yu 
Published: September 2023

LINKED CONTENTThis article is linked to Twum‐Barimah et al paper. To view this article, visit https://doi.org/10.1111/apt.15761
Letter: improved parsimony of genetic risk scores for coeliac disease through refined HLA modelling
Authors: Erlichster Michael , Bedo Justin , Skafidas Efstratios , Kwan Patrick , Kowalczyk Adam , Goudey Benjamin 
Published: September 2023

LINKED CONTENTThis article is linked to Sharp et al paper. To view this article, visit https://doi.org/10.1111/apt.15826
Chronic opioid use is associated with early biologic discontinuation in inflammatory bowel disease
Authors: Rhudy Christian , Perry Courtney L. , Singleton Michael , Talbert Jeffery , Barrett Terrence A. 
Published: September 2023

SummaryBackgroundChronic opioid use is associated with poorer clinical outcomes in inflammatory bowel disease.AimsTo investigate an association between chronic opioid use and persistence with biologic agents in management of inflammatory bowel disease.MethodsA total of 16 624 patients diagnosed with inflammatory bowel disease and receiving a first‐time biologic prescription from 2011 to 2016 were identified retrospectively from the Truven MarketScan Database. A cohort of 1768 patients were identified as chronic opioid users utilising outpatient prescription claims. Utilisation patterns of biologic therapies were assessed from inpatient administration and outpatient claims data, including persistence calculations. Information on healthcare utilisation and common comorbidities was also collected. A Cox regression model was constructed to assess the hazard of chronic opioid use on early discontinuation of biologic therapy controlling for disease severity.ResultsA mean 1.5 different biologic agents were utilised by inflammatory bowel disease patients with chronic opioid use (vs 1.37 in the comparator group; P < 0.0001). A lower proportion of the chronic opioid use cohort persisted on biologic therapies to the end of the study period (16.2% vs 33.5% P < 0.0001). Inflammatory bowel disease patients with chronic opioid use utilised more healthcare resources and had a higher rate of comorbidities than the reference cohort. Patients with chronic opioid use were 23% more likely (hazard ratio 1.23; 95% CI [1.16‐1.31]) to be non‐persistent with biologic therapy while accounting for relevant markers of disease acuity.ConclusionsChronic opioid use is associated with increased hazard of biologic discontinuation in inflammatory bowel disease. Symptoms of opioid withdrawal may mimic IBD flares thereby leading providers to inappropriately switch biologic therapies and compromise disease control.
Letter: elobixibatting for the long run
Authors: Tobi Martin , Talwar Harvinder , McVicker Benita 
Published: September 2023

LINKED CONTENTThis article is linked to Khanna & Camilleri papers. To view these articles, visithttps://doi.org/10.1111/apt.16143andhttps://doi.org/10.1111/apt.16290
Letter: SARS‐CoV‐2 infection in two IBD patients treated with dual targeted therapy
Authors: Privitera Giuseppe , Pugliese Daniela , Scaldaferri Franco , Armuzzi Alessandro 
Published: September 2023

LINKED CONTENTThis article is linked to Al‐Ani et al papers. To view these articles, visit https://doi.org/10.1111/apt.15779 and https://doi.org/10.1111/apt.16297
Letter: serum hepatitis B virus DNA and risk of hepatocellular carcinoma in patients with chronic hepatitis B—authors' reply
Authors: Kim Gi‐Ae , Lim Young‐Suk 
Published: September 2023

LINKED CONTENTThis article is linked to Kim et al and Huang et al papers. To view these articles, visitc https://doi.org/10.1111/apt.15725 and https://doi.org/10.1111/apt.16264
Editorial: incorporating liver stiffness to risk scores for HCC in patients with chronic hepatitis B treated with oral antivirals: ready to use or not?
Authors: Yang Hwai‐I , Hsu Yao‐Chun 
Published: September 2023

LINKED CONTENTThis article is linked to Chon et al paper. To view this article, visit https://doi.org/10.1111/apt.16267
Letter: elobixibatting for the long run—authors’ reply
Authors: Khanna Lehar , Camilleri Michael 
Published: September 2023

LINKED CONTENTThis article is linked to Khanna & Camilleri and Tobi et al papers. To view these articles, visit https://doi.org/10.1111/apt.16143 and https://doi.org/10.1111/apt.16270
Development and validation of an automated microfluidic perfusion platform for parallelized screening of compounds in vitro
Authors: Brugnoli Francesca R. , Holy Marion , Niello Marco , Maier Julian , Hanreich Marcus , Menzel Mario , Haberler Matthias , Zulus Niklas , Pickl Thomas , Ivanova Christa , Muiznieks Lisa D. , Garlan Benjamin , Sitte Harald H. 
Published: September 2023

AbstractMonoamine transporters are of great interest for their role in the physiological activity of the body and their link to mental and behavioural disorders. Currently, static well‐plate assays or manual perfusion systems are used to characterize the interaction of psychostimulants, antidepressants and drugs of abuse with the transporters but still suffer from significant drawbacks caused by lack of automation, for example, low reproducibility, non‐comparability of results. An automated microfluidic platform was developed to address the need for more standardized procedures for cell‐based assays. An automated system was used to control and drive the simultaneous perfusion of 12 channels on a microfluidic chip, establishing a more standardized protocol to perform release assays to study monoamine transporter‐mediated substrate efflux. D‐Amphetamine, GBR12909 (norepinephrine transporter) andp‐chloroamphetamine, paroxetine (serotonin transporter) were used as control compounds to validate the system. The platform was able to produce the expected releasing (D‐Amphetamine,p‐chloroamphetamine) or inhibiting (GBR12909, paroxetine) profiles for the two transporters. The reduction of manual operation and introduction of automated flow control enabled the implementation of stronger standardized protocols and the possibility of obtaining higher throughput by increasing parallelization.
A qualitative study assessing the barriers and facilitators to physical activity in adults with hearing loss
Authors: Goodwin Maria V. , Hogervorst Eef , Maidment David W. 
Published: September 2023

AbstractObjectivesGrowing epidemiological evidence has shown hearing loss is associated with physical inactivity. Currently, there is a dearth in evidence investigating why this occurs. This study aimed to investigate the barriers and facilitators to physical activity in middle‐aged and older adults with hearing loss.DesignIndividual semi‐structured qualitative interviews.MethodsA phenomenological approach was taken. Ten adults (≥40 years) were interviewed via videoconferencing. The interview schedule was underpinned by the capability, opportunity, motivation and behaviour (COM‐B) model. Reflexive thematic analysis was used to generate themes, which were subsequently mapped onto the COM‐B model and behaviour change wheel.ResultsNine hearing loss specific themes were generated, which included the following barriers to physical activity: mental fatigue, interaction with the environment (acoustically challenging environments, difficulties with hearing aids when physically active) and social interactions (perceived stigma). Environmental modifications (digital capabilities of hearing aids), social support (hearing loss‐only groups) and hearing loss self‐efficacy were reported to facilitate physical activity.ConclusionsMiddle‐aged and older adults with hearing loss experience hearing‐specific barriers to physical activity, which has a deleterious impact on their overall health and well‐being. Interventions and public health programmes need to be tailored to account for these additional barriers. Further research is necessary to test potential behaviour change techniques.
Red blood cell endothelial nitric oxide synthase: A major player in regulating cardiovascular health
Authors: LoBue Anthea , Heuser Sophia K. , Lindemann Marla , Li Junjie , Rahman Masudur , Kelm Malte , Stegbauer Johannes , Cortese‐Krott Miriam M. 
Published: September 2023

AbstractRed blood cells (RBCs) have traditionally been seen as simple carriers of gases and nutrients in the body. One important non‐canonical function of RBCs in the cardiovascular system is the regulation of nitric oxide (NO) metabolism. It has been shown that RBCs can scavenge NO, transport NO metabolites and produce NO in hypoxic conditions, thereby inducing hypoxic vasodilation. RBCs also express endothelial nitric oxide synthase (eNOS). However, the physiological significance of RBC eNOS has been controversial for many years. This review article provides a comprehensive overview of the experimental research on RBC eNOS signalling in vivo. The data show that RBC eNOS signalling modulates intracellular NO production and NO–haem levels, as well as participating in extracellular paracrine NO metabolite signalling, which contributes to regulating peripheral vascular resistance, blood pressure and cardioprotection. Additionally, this article explores the molecular mechanisms of sytemic regulation mediated by RBC eNOS and the implications of RBC eNOS in cardiovascular health and disease.
Identification and differentiation of vertical movement through morphological changes and stratigraphic imprint: Two distinct uplifting mechanisms in the upper Calabrian accretionary wedge, western Ionian Sea
Authors: Pandolpho Bruna T. , Urlaub Morelia , Berndt Christian , Bialas Jörg 
Published: September 2023

AbstractThe seafloor morphology reflects both past and on‐going sedimentary, oceanographic and tectonic processes. Vertical movement is one of the drivers responsible for reshaping the seafloor through forming steep flanks that decrease slope stability, favour landslides, change current paths, form minibasins and control the sediment deposition, distribution and geometry. Here, we make use of these interactions to derive vertical movements and constrain the active tectonic processes at the western termination of the upper Calabrian accretionary wedge from the integrated analysis of bathymetric, backscatter, surface attributes and high‐resolution reflection seismic data. Within this area, we identify two types of deformational features and mechanisms that affect the depositional, erosional and tectonic processes at different scales. These include the deviation of channels, landslide scars, mass transport deposits (MTDs), separated drifts, sediment waves, lineaments and offset seafloor structures. The first type (long‐wavelength uplift) is an uplifted 22‐km‐wide region, in which seismic onlap relationships and the dip of deep reflectors suggest long‐lasting but slow tectonic uplift affecting sedimentation, and the second type (short‐wavelength uplift) includes three narrow elongated structures and one circular dome encircling the first region of uplift. We interpret that the first type of uplift feature was caused by tectonic deformation, while the second type is interpreted as formed by the fast uplift, tilting and faulting of modern sediments caused by diapirism due to rapid sedimentation in response to the first tectonically driven uplift. The study provides insight into the complex interaction of tectonic and sedimentary processes in the upper Calabrian accretionary wedge.
A novel cyclic peptide library immobilized on gel‐type beads focusing on rapid construction and characterization for comprehensive drug discovery
Authors: Sasaki Toru , Kasama Takeshi , Nokihara Kiyoshi 
Published: September 2023

AbstractMedium sized molecules such as peptides and macrocycles have recently drawn much attention as potent sources of medicinal lead compounds, whereas the possibility of obtaining a practical drug from them remains limited. The present paper describes a concept of discovering novel medicinal targets or binding modes as well as lead compounds by the one‐peptide‐on‐one‐bead (OPOB) technology for comprehensive screening. The difficulty and problems in conventional drug discovery methods that generally deal with one predetermined target are considered. The building blocks used for the present libraries were selected based on previous results in development of peptidic drugs. Each constituent has the common structure of cyclic form prepared by disulfide of cysteinyl residues or thioether linkages, additionally a methionine residue was inserted for the site‐specific rapid cleavage by cyanogen bromide to liberate the immobilized peptides allowing reliable characterization by MALDI‐TOF‐MS/MS without LC‐purification. Thus, a high throughput construction method for cyclic peptide libraries as well as characterization of single bead are proposed for drug discovery.
Long term results of video‐assisted anal fistula treatment for complex anal fistula: another shattered dream?
Authors: La Torre Marco , Goglia Marta , Micarelli Alessandro , Fiori Enrico , D'Andrea Vito , Grossi Ugo , Tierno Simone Maria , Tomassini Federico , Gallo Gaetano 
Published: September 2023

AbstractAimComplex anal fistula represents a burden for patients, and its management is a challenge for surgeons. Video‐assisted anal fistula treatment (VAAFT) is one sphincter‐sparing technique. However, data on its long‐term effectiveness are scant. We aimed to explore the outcomes of VAAFT in a retrospective cohort of patients referred to a tertiary centre.MethodConsecutive adult patients with a minimum of 2 years’ follow‐up after VAAFT were reviewed. Patients were followed up to 5 years postoperatively. Failure was defined as incomplete healing of the external orifice(s) during the first 6 months. Recurrence was defined as new radiologically and/or clinically confirmed onset of the fistula after primary healing. A generalized linear model was fitted to evaluate the association between failure and sociodemographic characteristics. Predictors of recurrence were determined in a subgroup analysis of patients found to be free from disease at 6 months postoperatively.ResultsOverall, 106 patients (70% male; mean age 41 years) were reviewed. Of these 86% had a previous seton placement. Fistulas were either high trans‐sphincteric (74%), suprasphincteric (12%) or extrasphincteric (13%). Eight (7%) patients experienced postoperative complications, none of which required reintervention. Mean follow‐up was 53 ± 13.2 months. VAAFT failed in 14 (13%) patients. The overall recurrence rate ranged from 29% at 1 year to 63% at 5 years. Multiple external orifices, suprasphincteric fistula, younger age, previous surgery and higher complexity of the fistulous tract were independent risk factors for recurrence.ConclusionVAAFT is a safe sphincter‐sparing technique. The initially high success rate decreases over time and relates to a higher degree of complexity.
A Stearns–Noechel colour prediction model reconstructed from gridded colour solid of nine primary colours and its application
Authors: Sun Xianqiang , Xue Yuan , Xue Jingli , Jin Guang 
Published: September 2023

AbstractA full gamut colour solid model consisting of three lightness planes, 18 colour mixing units and 360 grid points is constructed from nine primary coloured fibres: red (R), yellow (Y), green (G), cyan (C), blue (B), magenta (M), dark grey (O1), medium grey (O2) and light grey (O3). Subsequently, the 213 coloured yarns and fabrics containing different lightness, hue and saturation were prepared according to the mixing ratio parameters in the colour solid. The Stearns–Noechel colour prediction algorithm, which predicts reflectance using coloured fibre mixing ratios, was improved and applied according to the requirements of colour prediction; and the Stearns–Noechel proportion prediction algorithm, which predicts coloured fibre mixing ratios by reflectance, was refined and employed in accordance with the demands of proportion prediction. Then, the 12 additional coloured fabrics were fabricated and their corresponding measurement data were used on the algorithm for validating its forecasting capabilities. The final experimental results reveal that the maximum colour difference for colour prediction is 5.5, the minimum is 1.7, and the average is 3.7; the maximum colour difference for proportion prediction is 3.3, the minimum is 0.3, and the average is 1.6. Therefore, this approach is promising to improve the colour reproduction issues encountered in the processing of three‐channel computer numerical control (CNC) spinning.
Flemish equine veterinarians' perceptions on the use of and client communication about complementary and alternative veterinary medicine
Authors: Keller Pia , Hudders Liselot , Decloedt Annelies 
Published: September 2023

AbstractBackgroundComplementary and alternative veterinary medicine (CAVM) is increasingly popular in horses. As CAVM usage could have risks, client–veterinarian communication about CAVM is crucial.ObjectivesEvaluating equine veterinarians' attitude towards CAVM, their CAVM usage and veterinarian–client communication about CAVM.Study designCross‐sectional study.MethodA telephone survey was conducted among equine veterinarians providing ambulatory care on a daily or weekly basis. The first section of the survey included questions about the veterinarians' attitude towards CAVM and their CAVM usage. The second section focused on veterinary–client communication about CAVM.ResultsWhen herbs are included as CAVM modality, 83% of the participants applied CAVM. Nighty‐eight percent had already communicated with horse owners about CAVM and 81% agreed to be open to talk about CAVM. However, 95% agreed that sometimes CAVM usage takes place without disclosure to the veterinarian. The majority of participants communicated about CAVM on a weekly (40%) or daily (22%) basis, most often in person during consultations (99%) or via phone (32%). The median percentage of conversations about CAVM initiated by the owner was 50% (range 50%–80%). When the veterinarian initiated the conversation, this was usually by mentioning it as a treatment option, mostly in addition to conventional treatments. Some participants directly asked about CAVM use in the information‐gathering phase.Main limitationsA convenience sample was used due to lack of data on the number of equine veterinarians in Flanders. Potential favourability bias with higher participation of veterinarians interested in CAVM.ConclusionEquine veterinarians generally had a positive attitude towards CAVM use, although this depended on the specific modality. Veterinarian–client communication about CAVM occurs frequently in ambulatory care. An open dialogue with horse owners about CAVM is important to provide information about CAVM and thus enable them to make informed decisions concerning CAVM usage, together with their veterinarian.
Emotion regulation of the family therapist
Authors: Rober Peter 
Published: September 2023

AbstractOutcome research highlights the importance of the therapeutic alliance for the outcome of therapy. Meta‐analyses suggest that in family therapy, the therapeutic alliance is even more important than in individual therapy. In family therapy, however, the alliance is more complex than in individual therapy. Through empathy, authenticity and hopefulness the therapist can contribute to an effective alliance. Sometimes during the session, a therapist may experience strong emotions that are in tension with his/her therapeutic aspirations of empathetic listening, authenticity and hopefulness. A therapist might experience boredom instead of curiosity, irritation instead of acceptance, shame instead of authenticity. There is need for some kind of emotion regulation to protect the alliance. Furthermore, as some authors suggest, the therapist's emotions – even the emotions that are first glance seem harmful to the alliance – may also be useful for the therapist. Several case stories illustrate the different ways in which family therapists can deal with their emotions in the session.