bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of phytoconstituents of Triticum aestivum grass extracts on nutritional attributes, antioxidant, and antimicrobial activities against food pathogens with molecular in silico investigation
Authors: Kaviya Mohandass , Balamuralikrishnan Balasubramanian , Sangeetha Thangavelu , Senthilkumar Natchiappan , Malaisamy Arunkumar , Sivasamy Murugasamy , Poorni Loganathan , Pushparaj Karthika , Arun Meyyazhagan , Anand Arumugam Vijaya 
Published: April 2023

AbstractThe plant‐based medicine and diet is gaining importance in recent days. The consumption of Triticum aestivum grass in the form of juice and tablets is increasing among common people. The present study elaborates on the nutritional, antioxidant, and antimicrobial potential of a nongenetically modified type of T. aestivum grass, along with the evidence of molecular docking studies. The T. aestivum grass extracts like decoction, aqueous, ethanol, and chloroform were subjected to preliminary phytochemical tests, quantitative estimation, antioxidant analysis, and antimicrobial activity determination. The ethanolic extract that had good antioxidant and antimicrobial potential was subjected to gas column–mass spectroscopy (GC–MS) analysis and the compounds identified were docked against the antioxidant and antimicrobial receptors. The decoction and aqueous extracts performed well in preliminary qualitative tests with the presence of most of the phytochemicals tested. The decoction, aqueous, and ethanolic extracts possessed good concentrations of the phytochemicals. The decoction had about 210.83 ± 9.16 and 154.16 ± 0.33 mg/g of carbohydrates and proteins, respectively, while the aqueous extract had about 10.91 ± 0.08 mg/g of amino acids and the ethanolic extract had about 52.5 ± 1.4 mg/g of phenolic content, which were the highest concentration of the phytochemicals observed among the extracts. Along with phytochemical potential, good antioxidant potential in the DPPH and ABTS by decoction as well as ethanolic extract with nearly 40 and 90% inhibition, respectively, and in FRAP by aqueous extract with maximum OD value. The ethanolic extract exhibited the best inhibition potential against the Staphylococcus aureus about 28 ± 1 mm, Pseudomonas aeruginosa with 20 ± 2 mm, Bacillus cereus at 20 ± 1 mm by the ethanolic extract at 200 μg concentration, and Aspergillus fumigatus and A. niger at 15 ± 0 mm by the aqueous extract at 200 μg concentration. The GC–MS analysis revealed the presence of terpenoids, alkaloids, and phenols, which on docking had highest binding capacity toward the antioxidant and antimicrobial receptors.
Comprehensive commodity price forecasting framework using text mining methods
Authors: An Wuyue , Wang Lin , Zhang Dongfeng 
Published: April 2023

AbstractExploiting advanced and appropriate methods to construct high‐quality features from different types of data becomes crucial in agricultural futures price forecasting. Thus, this study develops a comprehensive commodity price forecasting framework using text mining methods. First, the modal features of the price series are extracted using the proposed Integrated‐EEMD‐VMD‐SE method, and dynamic topic sentiment features are constructed from Weibo texts using the proposed dynamic topic model joint sentiment analysis method. Second, combined with statistical variables, lag order selection and feature selection are performed on these comprehensive factors. Finally, 12 comparative prediction models are designed based on random forest (RF), long short‐term memory (LSTM), and multilayer perceptron (MLP), and empirical analysis is carried out on two cases of pork prices and soybean futures prices. The experimental results show that the proposed prediction framework has high prediction accuracy, and the mean absolute percentage error (MAPE) values are 1.00 and 0.92, respectively. The constructed time series modal features and dynamic topic sentiment features can significantly improve the performance of the prediction model.
Lymph node ratio‐based prognostic model for risk stratification and individualized adjuvant therapy for postoperative major salivary duct carcinoma
Authors: Zhang Di , Li Lixi 
Published: April 2023

AbstractBackgroundTo investigate the value of lymph node ratio (LNR) for postoperative major salivary duct carcinoma (MSDC) and to establish a model for prognosis assessment and treatment optimization.MethodsData of MSDC were retrieved in public database, and prognostic factors were identified by univariate and multivariate analyses. A nomogram and risk stratification system were constructed.ResultsFour hundred and eleven eligible patients were included (training cohort vs. validation cohort: 287: 124). LNR ≥0.09 was associated with worse overall survival (OS). Age at diagnosis, sex, T stage, and LNR were identified as prognostic factors and integrated into nomogram. Low‐risk patients were found to have better OS than high‐risk patients. Furthermore, postoperative radiotherapy (PORT) significantly improved OS in the high‐risk subgroup, but chemotherapy did not confer a long‐term survival benefit.ConclusionsA nomogram model integrating LNR could better assess postoperative prognosis and risk stratification in MSDC, and identify patients who might benefit from PORT to avoid overtreatment.
Influences of increasing water release of the Three Gorges Reservoir during dry season on water regimes of downstream lake
Authors: Li Xianghu , Ye Xuchun , Yao Jing , Lin Yaling , Xu Chengyu , Yuan Canyu 
Published: April 2023

AbstractThe severe and frequent drought in Poyang Lake, the largest freshwater lake in China, has seriously affected the local water resources security and wetland ecological security. Especially, the impoundment of the Three Gorges Reservoir (TGR) in the Yangtze River further aggravated the drought in lake. To explore the approaches to alleviate drought in Poyang Lake, this study simulated and quantified the influences of increasing water release of the TGR during the dry periods on water regimes of Poyang Lake, including the lake water level, duration of low water, flow velocity, flow field of lake, as well as potential suitable habitat area of migratory birds, based on a hydrodynamic model. Major results showed that the increase of water release of the TGR raised the lake water level, especially in the northern lake area, with the average lake level increase of 0.2–1.08 m and the lowest lake level increase of 0.16–0.68 m. Meanwhile, the duration of low water was significantly shortened, from 127 days to 87–116 days (threshold lake level of 12.0 m) at Xingzi station. In addition, the hydrodynamic simulations revealed that the increasing water release of the TGR reduced the lake flow velocity and discharge of Poyang Lake, which decreased the outflow of lake by 1.66–17.87 × 108 m3, accounting for about 0.47%–5.11% of the total outflow in the dry season. Finally, the potential suitable habitat area with 0.2–0.6 m water depth increased by 1.7–27.9 km2 in December–February, and showed a significant expansion trend in the central area of Poyang Lake. Outcomes of the study are useful for understanding the influences of water release of the TGR on water regimes of downstream lakes, and can provide valuable references for mitigating lake droughts in complex river–lake system.
Time to move beyond surgical classification systems for endometriosis
Authors: Hernández Cardona María Isabel , Ajewole Christana , Lewis Hannah , Carrillo Jorge F. , Castellanos Mario E. , Barish Stefanie , Villegas Echeverri Juan Diego , Lamvu Georgine 
Published: April 2023

AbstractEndometriosis is a common condition associated with chronic pelvic pain and infertility. Its pathogenesis is poorly understood, diagnosis relies on laparoscopy, and staging is based on extent of disease. Unfortunately, the current staging systems do not correlate well with pain severity and impact, nor do they predict prognosis, i.e., treatment success and recurrence of disease. In this article, we discuss the strengths and limitations of current staging systems and propose modifications that will enable better classification systems to be developed in the future.
Household food waste trending upwards in the United States: Insights from a National Tracking Survey
Authors: Li Ran , Shu Yiheng , Bender Kathryn E. , Roe Brian E. 
Published: April 2023

AbstractThree successive administrations have supported the United States' 2015 goal to reduce food waste. Households waste more food than other supply chain segments, however, few data sources are available to track US households' progress toward this goal. We provide insights from the first four waves of a novel national survey designed to track such waste. We find a 280% year‐over‐year increase in self‐reported waste between early 2021 and early 2022, which militates against national goal achievement. We find households wasted more food during weeks they dined out and that sample households dined out significantly more in 2022 than in 2021.
Pharmacist‐led dosing reduces tacrolimus intrapatient variability in lung transplant recipients
Authors: Yang Anita , McKnight Roxanne , Prom Alyson , Byrne Megan , Evans Rickey A. , Doligalski Christina T. 
Published: April 2023

AbstractIntrapatient variability (IPV) of tacrolimus has become a marker for predicting transplant outcomes, though minimal data exists regarding strategies to improve tacrolimus IPV. Following the implementation of comprehensive outpatient clinical pharmacy services, the impact of a dedicated lung transplant pharmacist on 1‐year tacrolimus variability and clinical outcomes in lung transplant recipients (LTRs) were investigated. A retrospective study of two LTR cohorts was conducted at a single‐center institution. Cohort 1 included LTRs from January 1, 2015 to December 31, 2017 with tacrolimus dose adjustments made by physicians or nurse practitioners, and were seen by a pharmacist on an ad hoc basis. Cohort 2 included LTRs from January 1, 2018 to December 31, 2019 with tacrolimus adjustments made solely by a pharmacist who saw them at each routine visit with the multidisciplinary team for the first year post‐transplant. The primary outcome assessed tacrolimus variability by the coefficient of variation 12 months post‐transplant. Secondary outcomes assessed post‐transplant hospital readmissions, acute cellular rejection (ACR), donor‐specific antibodies (DSA), and mortality at 12 months post‐transplant. No protocol changes occurred during the study period. Chi‐squared and t‐tests analyses were utilized. Sixty‐three LTRs were included, 39 patients in Cohort 1 and 24 in Cohort 2 with no significant differences between cohorts. At 1‐year post‐transplant, Cohort 2 had lower median tacrolimus variability (35.7% vs. 30.3%, p = 0.02) and more patients had a tacrolimus variability <30% (20.5% vs. 45.8%, p = 0.03). There were no differences in readmission rates, ACR, DSA, or mortality 12 months post‐transplant. Based on this single‐center limited cohort study, the integration of a dedicated ambulatory transplant pharmacist improved tacrolimus variability 1 year following lung transplant. Further studies are needed to assess long‐term morbidity and mortality rates.
Modulating pentenoate‐functionalized hyaluronic acid hydrogel network properties for meniscal fibrochondrocyte mechanotransduction
Authors: Burkey Kyley , Castillo Kayla , Elrod Philip , Suekuni Murilo T. , Aikman Elizabeth , Gehrke Stevin , Allgeier Alan , Robinson Jennifer L. 
Published: April 2023

AbstractKnee meniscus tears are one of the most common musculoskeletal injuries. While meniscus replacements using allografts or biomaterial‐based scaffolds are available, these treatments rarely result in integrated, functional tissue. Understanding mechanotransducive signaling cues that promote a meniscal cell regenerative phenotype is critical to developing therapies that promote tissue regeneration rather than fibrosis after injury. The purpose of this study was to develop a hyaluronic acid (HA) hydrogel system with tunable crosslinked network properties by modulating the degree of substitution (DoS) of reactive‐ene groups to investigate mechanotransducive cues received by meniscal fibrochondrocytes (MFCs) from their microenvironment. A thiol‐ene step‐growth polymerization crosslinking mechanism was employed using pentenoate‐functionalized hyaluronic acid (PHA) and dithiothreitol to achieve tunability of the chemical crosslinks and resulting network properties. Increased crosslink density, reduced swelling, and increased compressive modulus (60–1020 kPa) were observed with increasing DoS. Osmotic deswelling effects were apparent in PBS and DMEM+ compared to water; swelling ratios and compressive moduli were decreased in the ionic buffers. Frequency sweep studies showed storage and loss moduli of hydrogels at 1 Hz approach reported meniscus values and showed increasing viscous response with increasing DoS. The degradation rate increased with decreasing DoS. Lastly, modulating PHA hydrogel surface modulus resulted in control of MFC morphology, suggesting relatively soft hydrogels (E = 60 ± 35 kPa) promote more inner meniscus phenotype compared to rigid hydrogels (E = 610 ± 66 kPa). Overall, these results highlight the use of ‐ene DoS modulation in PHA hydrogels to tune crosslink density and physical properties to understand mechanotransduction mechanisms required to promote meniscus regeneration.
Perspectives of Indian dental residents on novel online practical examination during COVID‐19: A cross‐sectional study
Authors: Sajjan Girija S. , Praveen Dalavai , Gadde Praveen , Sajjan Suresh , Swamy Shivakumara , Chaitanya Penmatsa , Ramesh Konathala S. V. , Pulidindi Anil Kumar 
Published: April 2023

AbstractPurposeThis cross‐sectional study aimed to assess the graduating dental residents’ perspectives on the online clinical examination format.MethodsThe questionnaire used to assess the perspectives was developed via a focus group discussion and was validated for face and content validity, readability testing, and pilot testing for the online version. This self‐administered, online questionnaire integrated 15 Likert‐scale‐based multiple choice questions and one open‐ended question. It was distributed to the residents across 16 dental schools after the clinical examination was completed. The perspectives regarding examination preparation, the ability to transition to online mode, and the performance in the examination were assessed. Descriptive statistical analysis (counts and percentages) was performed.ResultsA total of 256 subjects participated in the study by returning the online survey. In the preparation phase, 70.7% (n = 181) residents reported anxiety and 56.1% (n = 144) reported stress. During the examinations, only 13.6% (n = 35) of the participants reported difficulty with internet speed. The majority, 64.6% (n = 165) of the participants reported that the absence of an external examiner face‐to‐face reduced anxiety. The compiled answers to the open‐ended question revealed that residents expressed inconvenience in digitizing the academic logbooks and clinical work. The poor quality of sound and images affected the display of skills.ConclusionsThe study revealed a moderate level of acceptance for the novel online practical examination method. The residents reported stress before and during the examination due to the sudden transition to an online examination. The online practical examination with modifications might be a viable alternative to the in‐person clinical examination.
Public perspective on medications to delay Alzheimer's disease symptoms
Authors: Rich Matthew B. , Blout Zawatsky Carrie L. , Botta Joseph J. , Christensen Kurt D. 
Published: April 2023

AbstractDisease‐modifying treatments for Alzheimer's disease are emerging. Our research examined how personal risk for AD may influence intentions to ask for medications to delay symptoms of AD, and how the availability of such medications impacts interest in AD‐related genetic testing. Invitations to a web‐based survey were posted on social media sites. Respondents were sequentially assigned to imagine that they had a 5%, 15%, or 35% chance of developing AD. They were then provided a hypothetical scenario describing a medication that delayed AD symptoms. After reporting intentions to ask for the medication, respondents were asked about their interest in genetic testing to predict AD risk. Data from 310 individuals were analyzed. Intentions to ask for a preventative medication were greater for respondents presented AD risks of 35% compared to risks of 15% and 5% (86% vs. 66% vs. 62%, respectively, p < 0.001). The proportion who would ask for genetic susceptibility testing increased from 58% to 79% when respondents were told to imagine that a medication that delayed AD symptoms existed (p < 0.001). Findings suggest that individuals who know they have an increased risk for AD are more likely pursue medications to delay onset of disease symptoms, and the availability of AD‐delaying treatments will increase interest in associated genetic testing. Findings provide insight about who will pursue emerging preventative medications, including individuals for whom the medications may be inappropriate, and the impact on genetic test utilization.
Association between human genetic variants affecting the host NK cell response and the development of herpes simplex virus type 1 encephalitis
Authors: Graninger Marianne , Vietzen Hannes , Puchhammer‐Stöckl Elisabeth 
Published: April 2023

AbstractHerpes simplex virus encephalitis (HSE) is a rare complication of herpes simplex virus type 1 (HSV‐1) infection or reactivation. It is so far unclear why only few patients develop HSE. As natural killer (NK) cells provide an important defense against HSV‐1, we investigated whether there is an association between distinct human genetic variants associated with the host NK cell response and HSE. Forty‐nine adult patients with confirmed HSE and 247 matched controls were analyzed for the distribution of the following genotypes: CD16A (FcγRIIIA) V/F and IGHG1 G1m3/17, both influencing antibody‐dependent cellular cytotoxicity; HLA‐E*0101/*0103, associated with NK cell activation; and SLFN13 rs9916629C/T associated with NK cell response. Homozygous HLA‐E*0101:0101 and HLA‐E*0103:0103 variants as well as the rs9916629CC genotype were overrepresented in HSE patients compared to controls (p ≤ 0.001). Notably, cooccurrence of the homozygous HLA‐E*0101 and rs9916629CC genotypes was present in 19% of patients but totally absent in controls (p ≤ 0.0001). Distribution of CD16A and IGHG1 variants did not differ between patients and controls. Our data show that the rare combination of HLA‐E*0101:0101 and rs9916629CC is significantly associated with HSE. Possibly, these genetic variations could be useful as clinical markers predicting HSE prognosis and helping to adapt the treatment of HSE in the individual patient.
Thermal behavior of modern and archeological enamel and dentin by in situ temperature‐dependent Raman spectroscopy
Authors: Kiseleva Daria , Pankrushina Elizaveta 
Published: April 2023

AbstractTeeth and bones are important bioarchives, which can be altered because of diagenesis or burning (cooking, funerary cremations, and fires). Though heating and diagenesis are different processes, an experimental heating of modern bioapatite reproduces in a short time effects similar to diagenetic processes occurring over geological time. The thermal behavior of modern and archeological human enamel and dentin using the in situ thermo‐Raman spectroscopy at 83–873 K was investigated to assess the structural changes in organic and mineral components of a tooth and their interrelationship. The ν1(PO4) vibrational mode in apatite is the most anharmonic and responsible for the reaction of the structure to external influences. The γiP isobaric Grüneisen parameters for archeological (0.41) and modern (0.24) enamel are different from those for fluor‐ (0.17) and chlorapatite (0.17), which indicates a stronger reaction of PO bonds in bioapatite PO4 tetrahedra to temperature changes as compared with geologic samples. The anomalies of the thermal dependences of the ν1(PO4) peak position and
(T) autocorrelation function are caused by the combined effect of different factors such as breaking of hydroxyl and hydrogen bonds, the loss of adsorbed and structural water, collagen denaturation, organic phase combustion, and removal and relocation of B‐ and A‐type carbonate ions. The thermal (273, 313, 341, and 363 K) and cold (~160 K) denaturation of collagen is reflected in the ν1(PO4) and
(T) dependences. The
(T) differences between modern and archeological dentin and enamel are contingent on bioapatite composition (proportions of adsorbed and structural water, hydroxyl and carbonate ions, and trace elements as well as different types of organic matter — low‐molecular noncollagen compounds and high‐molecular collagen). The results obtained contribute to the knowledge about the thermal transformations of the mineral and organic phases of modern and archeological tooth tissues and allow their structural alterations to be evaluated.
Serum infliximab levels and clinical response in hidradenitis suppurativa
Authors: Benassaia Erwin , Bouaziz Jean‐David , Jachiet Marie , Cordoliani Florence , Saussine Anne , Lepelletier Clemence , Goldwirt Lauriane , Cassius Charles , de Masson Adèle , Bagot Martine , Bachelez Hervé , Assan Florence 
Published: April 2023

AbstractBackgroundInfliximab (IFX) is a chimeric immunoglobulin G‐1κ monoclonal antibody that neutralises the biologic activity of tumour necrosis factor‐α, and has shown efficacy (off‐label) for the treatment of severe hidradenitis suppurativa (HS). The relationship between clinical response and IFX pharmacokinetics (PK) in HS is currently unknown.ObjectivesTo investigate the relationship between the trough serum concentration of IFX (TSI) and the clinical response to IFX in moderate‐to‐severe HS between 12th and 24th week (W12–W24) after IFX treatment onset.MethodsWe conducted a retrospective, monocentric study in a French dermatology tertiary care centre (Saint‐Louis hospital, Paris) between January 2013 and January 2022. Adult patients treated with IFX for moderate‐to‐severe HS were included if (i) they had at least one IFX serum dosage during follow‐up, and (ii) they had a measurable Hidradenitis Suppurativa Clinical Response (HiSCR) score between the 12th and 24th week (W12–W24). Patients received IFX infusions every 4, 6 or 8 weeks at 5, 7.5 or 10 mg/kg of body weight dosages.ResultsTwenty‐two patients (48.9%; median age: 36 [31–43] years; 7 [31.8%] female) who had at least one IFX serum dosage between W12–W24 were enroled. The median TSI between W12 and W24 was significantly higher in the responding group compared to the nonresponding group of patients: 14.8 (12.1–15.7) versus 1.6 (0.8–3.5) µg/mL, respectively (p = 0.01). Using receiver operating characteristics (ROC) analysis curve, a TSI threshold of 7 µg/mL at W12–W24 showed sensitivity and specificity of 0.75 and 0.94, respectively.ConclusionsThis study supports some degree of correlation between clinical response and TSI in HS, and paves the way for prospective studies investigating correlations between PK, immunogenicity and clinical response in severe HS patients receiving IFX.