bluuebunny/crossref_metadata_2025_split huggingface dataset:
Invar Effect in the Wide and Higher Temperature Range by Coherent Coupling in Fe‐Based Alloy
Authors: Cui Jin , Sun Ying , Shi Kewen , Deng Sihao , Ma Tianyu , Du Yi , Zhang Jialin , Cheng Ningyan , Yuan Xiuliang , He Lunhua , Li Bing , Li Xiaolong , Chen Shuangming , Gu Yueliang , Wang Cong 
Published: September 2023

AbstractInvar alloys with zero thermal expansion (ZTE), isotropy, high operation temperature, and wide temperature range are of great significance in fields such as aerospace and modern industry. However, it is difficult to simultaneously meet the above characteristics in one material. The traditional methods like element or vacancies doping would increase the operation temperature but at the expense of ZTE behavior. Here, by the coherent coupling between two cubic phases, the isotropic ZTE metallic material with the higher cut‐off temperature (560 K) and a wide operation temperature range (ΔT = 200 K) is obtained in Fe2.75Co0.25PtB0.25. The operation temperature range is much higher than that of commercial Fe0.65Ni0.35 Invar alloy and meets the applications at elevated temperatures. High‐angle annular dark field images and synchrotron X‐ray diffraction prove that by the coherent interfacial coupling between the A1 and its coherent L12 nanodomains, the original negative thermal expansion or positive thermal expansion performances for them can be changed into the same ZTE performances. This thermal expansion regulation strategy realized by coherent coupling will lead to an innovative and significant revolution for ZTE design and promote its development and application.
Exploring the Potential of Nanogels: From Drug Carriers to Radiopharmaceutical Agents
Authors: Kubeil Manja , Suzuki Yota , Casulli Maria Antonietta , Kamal Rozy , Hashimoto Takeshi , Bachmann Michael , Hayashita Takashi , Stephan Holger 
Published: September 2023

AbstractNanogels open up access to a wide range of applications and offer among others hopeful approaches for use in the field of biomedicine. This review provides a brief overview of current developments of nanogels in general, particularly in the fields of drug delivery, therapeutic applications, tissue engineering, and sensor systems. Specifically, cyclodextrin (CD)‐based nanogels are important because they have exceptional complexation properties and are highly biocompatible. Nanogels as a whole and CD‐based nanogels in particular can be customized in a wide range of sizes and equipped with a desired surface charge as well as containing additional molecules inside and outside, such as dyes, solubility‐mediating groups or even biological vector molecules for pharmaceutical targeting. Currently, biological investigations are mainly carried out in vitro, but more and more in vivo applications are gaining importance. Modern molecular imaging methods are increasingly being used for the latter. Due to an extremely high sensitivity and the possibility of obtaining quantitative data on pharmacokinetic and pharmacodynamic properties, nuclear methods such as single photon emission computed tomography (SPECT) and positron emission tomography (PET) using radiolabeled compounds are particularly suitable here. The use of radiolabeled nanogels for imaging, but also for therapy, is being discussed.
Intermediates Regulation via Electron‐Deficient Cu Sites for Selective Nitrate‐to‐Ammonia Electroreduction
Authors: Gu Zhengxiang , Zhang Yechuan , Wei Xuelian , Duan Zhenyu , Gong Qiyong , Luo Kui 
Published: September 2023

AbstractAmmonia (NH3), known as one of the fundamental raw materials for manufacturing commodities such as chemical fertilizers, dyes, ammunitions, pharmaceuticals, and textiles, exhibits a high hydrogen storage capacity of ≈17.75%. Electrochemical nitrate reduction (NO3RR) to valuable ammonia at ambient conditions is a promising strategy to facilitate the artificial nitrogen cycle. Herein, copper‐doped cobalt selenide nanosheets with selenium vacancies are reported as a robust and highly efficient electrocatalyst for the reduction of nitrate to ammonia, exhibiting a maximum Faradaic efficiency of ≈93.5% and an ammonia yield rate of 2360 µg h−1 cm−2 at −0.60 V versus reversible hydrogen electrode. The in situ spectroscopical and theoretical study demonstrates that the incorporation of Cu dopants and Se vacancies into cobalt selenide efficiently enhances the electron transfer from Cu to Co atoms via the bridging Se atoms, forming the electron‐deficient structure at Cu sites to accelerate NO3− dissociation and stabilize the *NO2 intermediates, eventually achieving selective catalysis in the entire NO3RR process to produce ammonia efficiently.
Architecture of Vanadium‐Based MXene Dysregulating Tumor Redox Homeostasis for Amplified Nanozyme Catalytic/Photothermal Therapy
Authors: Zhao Ruoxi , Zhu Yanlin , Feng Lili , Liu Bin , Hu Yaoyu , Zhu Haixia , Zhao Zhiyu , Ding He , Gai Shili , Yang Piaoping 
Published: September 2023

AbstractTaking the significance of the special microenvironment for tumor cell survival into account, disrupting tumor redox homeostasis is highly prospective for improving therapeutic efficacy. Herein, a multifunctional 2D vanadium‐based MXene nanoplatform, V4C3/atovaquone@bovine albumin (V4C3/ATO@BSA, abbreviated as VAB) has been elaborately constructed for ATO‐enhanced nanozyme catalytic/photothermal therapy. The redox homeostasis within the tumor cells is eventually disrupted, showing a remarkable anti‐tumor effect. The VAB nanoplatform with mixed vanadium valence states can induce a cascade of catalyzed reactions in the tumor microenvironment, generating plenty of reactive oxygen species (ROS) with effective glutathione consumption to amplify oxidative stress. Meanwhile, the stable and strong photothermal effect of VAB under near‐infrared irradiation not only causes the necrosis of tumor cells, but also improves its peroxidase‐like activity. In addition, the release of ATO can effectively alleviate endogenous oxygen consumption to limit triphosadenine formation and inhibit mitochondrial respiration. As a result, the expression of heat shock proteins is effectively suppressed to overcome thermoresistance and the production of ROS can be further promoted due to mitochondrial injury. Moreover, VAB also presents high photoacoustic and photothermal imaging performances. In brief, the multifunctional nanoplatform can provide ATO‐enhanced nanozyme catalytic/photothermal therapy with broadening the biomedical applications of vanadium‐based MXene.
In Situ Spectroscopic Detection of Large‐Scale Reorientations of Transmembrane Helices During Influenza A M2 Channel Opening**
Authors: Paschke Ronja Rabea , Mohr Swantje , Lange Sascha , Lange Adam , Kozuch Jacek 
Published: September 2023

AbstractViroporins are small ion channels in membranes of enveloped viruses that play key roles during viral life cycles. To use viroporins as drug targets against viral infection requires in‐depth mechanistic understanding and, with that, methods that enable investigations under in situ conditions. Here, we apply surface‐enhanced infrared absorption (SEIRA) spectroscopy to Influenza A M2 reconstituted within a solid‐supported membrane, to shed light on the mechanics of its viroporin function. M2 is a paradigm of pH‐activated proton channels and controls the proton flux into the viral interior during viral infection. We use SEIRA to track the large‐scale reorientation of M2’s transmembrane α‐helices in situ during pH‐activated channel opening. We quantify this event as a helical tilt from 26° to 40° by correlating the experimental results with solid‐state nuclear magnetic resonance‐informed computational spectroscopy. This mechanical motion is impeded upon addition of the inhibitor rimantadine, giving a direct spectroscopic marker to test antiviral activity. The presented approach provides a spectroscopic tool to quantify large‐scale structural changes and to track the function and inhibition of the growing number of viroporins from pathogenic viruses in future studies.
Crystal structure, optical properties, mobility, and photoelectric performance of [PEA]3[Bi2I9]
Authors: Wang Xueze , Li Mengqing , Cao Wenhuan , Li Wenhui , Gao Huidan , Zhang Qingfu , Zhou Huawei , Zhang Xianxi 
Published: September 2023

Lead halide‐based salts exhibit good photoelectric properties; however, the use, leakage, and recovery of toxic lead require careful consideration. Therefore, developing a lead‐free optoelectronic material conveniently and quickly is very important. Moreover, there is relatively little research on the salts of bismuth halides. In this study, we synthesized [PEA]3[Bi2I9] single crystals (SC) by volatilizing N,N‐dimethylformamide (DMF) solvent at 70°C. The crystal system and spatial group of [PEA]3[Bi2I9] are monoclinic and P21/n, respectively. The Tauc plot reveals the optical band gap of the [PEA]3[Bi2I9] SC at 2.048 eV. The carrier mobility of [PEA]3[Bi2I9] SC is 47.4 cm2 V−1 s−1. Steady‐state fluorescence and time‐resolved fluorescence spectrum indicate that there are four fluorescence peaks and about 7 μs lifetime, respectively. The photodetector based on [PEA]3[Bi2I9] SC under different voltages (0.5, 1, 1.5, 2, and 2.5 V) exhibits stability and regularity with turning‐on/off of the light. In addition, thermogravimetric analysis (TGA) tests indicate that [PEA]3[Bi2I9] SC has considerable thermal stability at temperatures up to 260°C, showing promise for becoming a high temperature resistant and nontoxic sensor with good application prospects.
Using epoxy/acid stoichiometry to rationally tune the thermomechanical and reprocessing properties of epoxy vitrimers
Authors: Sheng Jie , Geng Tie , Jiang Lin , Wu Haihong , Li Jiquan , Huang Zhengqiang , You Jing , Guo Yonggang 
Published: September 2023

AbstractEpoxy vitrimers immerged as an appealing alternative to traditional plastics. However, high loading of catalyst and harsh processing conditions are prerequisites to fully exploit the vitrimer properties. In this work, stoichiometric ratio, an often neglected factor, was utilized to further accelerate the rate of dynamic transesterification. Epoxy vitrimers with four epoxy/acid stoichiometries (60:30, 40:30, 30:30, and 24:30) were prepared to comparatively analyze their network structures, thermomechanical properties, and reprocessing properties. It was found that the off‐stoichiometry epoxy vitrimers have almost the similar excellent thermal stability as epoxy thermosets. Vitrimers with excess epoxy showed increased tensile strength (from 26.3 to 42.7 MPa) and decreased elongation at the break (from 5.5% to 1.7%). Meanwhile, excess epoxy induced abundant of hydroxy groups in the vitrimers, imparting satisfactory repairability, reformability, and recyclability. Specifically, epoxy/acid (60:30) repaired 94% in 10 min at 180°C, and maintained over 93% mechanical properties after reforming and recycling. However, simply increasing the epoxy content will compromise the structural integrity of the network, simultaneously resulting in reduced toughness of epoxy vitrimers. These findings demonstrated that epoxy/acid stoichiometry can be a powerful tool to develop epoxy vitrimers with both excellent thermomechanical and reprocessing properties.
“Bulgaria on three seas!”: An example of regression as a defense mechanism experienced by a large‐group in a response to its national inferiority complex
Authors: Nikolova Yana 
Published: September 2023

Abstract“Bulgaria on three seas” is a commonly used phrase in Bulgaria. It is used on national celebration days, around government election days, in populist campaigns, on TV shows, on social media, at folkloric concerts and gatherings and in simple everyday conversations. The phrase signifies a specific golden century of Bulgarian history characterized by the fact that Bulgaria reaches the Black, White and Adriatic seas. Today, the phrase is regularly used by Bulgarians when they talk about their country. This glorious time is also used as part of the political and public rhetoric where ideology has nationalistic character. It is present during political public debates about the country's reactions to both its past and its future. The phrase “Bulgaria on three seas” lifts the national spirit during moments of struggle. And all that raises questions about why Bulgarians constantly refer to this part of their history and what this regressive behavior demonstrates. This article aims to provide a psychological explanation, combining the concepts of regression (going back to the past), denial of the present and national inferiority complex (perceived helplessness and weakness) in order to analyze how a nation could respond to its own feelings of national group inferiority. It explains how regression is a response to one's own feelings of inferiority and it contributes to the studies of large‐group psychology established by Vamik Volkan by offering an alternative explanation. The work demonstrates that regression is the Bulgarian way of dealing with its own inferiority complexes when in denial about what is happening in the present. This takes place when group identity (or an aspect of it) is questioned. The article also provides a pathway to further exploration of how other nations deal with similar experiences.
Establishing pathogen log reduction value targets for direct potable reuse in the United States
Authors: Gerrity Daniel , Crank Katherine , Steinle‐Darling Eva , Pecson Brian M. 
Published: September 2023

AbstractCommunities are now turning to potable reuse to augment their water supply portfolios in response to increasing demand and climate uncertainty. One barrier to broader implementation is a lack of regulations for direct potable reuse (DPR) in some locations. An incomplete understanding of the foundation of existing DPR frameworks may be contributing to this barrier. The objective of this study was to use a publicly available quantitative microbial risk assessment (QMRA) tool—DPRisk—to explain the basis behind California's existing indirect potable reuse regulations, California's draft DPR regulations, and an Expert Panel's response to those draft regulations. Then, leveraging a robust raw wastewater pathogen dataset from the literature, DPRisk was used to justify two alternatives: one based on maximum simulated pathogen concentrations and the other based on 97.4th percentile concentrations. The latter represents an effort to seek equivalency between “raw wastewater” (i.e., California) and “treated effluent” (i.e., Texas) approaches. Using justified QMRA assumptions, the baseline log reduction value (LRV) targets were determined to be 15/11/11 (maximum) or 13/10/10 (97.4th percentile) for viruses, Giardia, and Cryptosporidium. Additionally, instead of augmenting the baseline LRVs to account for undetected treatment process failures, tolerances for off‐specification conditions (e.g., up to 3 logs for 3–12 days per year) were characterized. With this foundational knowledge, stakeholders can better understand and adopt these frameworks or use DPRisk to establish a new framework that better addresses their unique constraints, including considerations for preferred treatment paradigms and capital and operational costs.
Integrated network pharmacology and metabolomics analyses of the mechanism underlying the efficacy of Ma‐Mu‐Ran Antidiarrheal Capsules against dextran sulfate sodium–induced ulcerative colitis
Authors: Huang Hailing , Duan Bailu , Zheng Sili , Ye Yan , Zhang Dongning , Huang Zhuang , Wang Shanshan , Zhang Fengyun , Huang Ping , Huang Fang , Han Lintao 
Published: September 2023

AbstractThe current study utilizes a comprehensive network pharmacology and metabolomics analysis to investigate the mechanism of action of Ma‐Mu‐Ran Antidiarrheal Capsules (MMRAC) for the treatment of ulcerative colitis (UC). In this study, we established a mouse model of UC using dextran sulfate sodium. Colonic tissues were collected from mice and then subjected to hematoxylin and eosin staining, as well as histopathological analysis, to assess the therapeutic effect of MMRAC. Furthermore, we assessed the mechanisms through which MMRAC combats UC by employing integrated metabolomics and network pharmacology strategies. Lastly, we validated the key targets identified through western blot and molecular docking. An integrated network of metabolomics and network pharmacology was constructed using Cytoscape to identify eight endogenous metabolites involved in the therapeutic action of MMRAC on UC. Further comprehensive analyses were focused on four key targets and their associated core metabolites and pathways. The results of western blot and molecular docking demonstrated that MMRAC could modulate key targets and their expression levels. The cumulative results indicated that MMRAC restored intestinal function in UC, reduced inflammatory responses, and alleviated oxidative stress by influencing the methionine and cysteine metabolic pathways, as well as the urea cycle. In addition, it had an impact on arginine, proline, glutamate, aspartate, and asparagine metabolic pathways and their associated targets.
Immunohistochemical expression of NRF2 is correlated with the magnitude of inflammation and fibrosis in chronic liver disease
Authors: To Keii , Okada Kosuke , Watahiki Takahisa , Suzuki Hideo , Tsuchiya Kiichiro , Tokushige Katsutoshi , Yamamoto Masakazu , Ariizumi Shun‐ichi , Shoda Junichi 
Published: September 2023

AbstractBackgroundThe nuclear factor E2‐related factor 2–Kelch‐like Ech‐associated protein (NRF2–KEAP1) pathway is a major cellular defense mechanism against oxidative stress. However, the role of NRF2–KEAP1 signaling in the development of chronic liver disease remains unclear.MethodsClinical liver specimens from 50 hepatocellular carcinoma (HCC) developed from non‐alcoholic steatohepatitis (NASH), 49 HCCs developed from chronic viral hepatitis C (CHc), and 48 liver metastases of colorectal cancer (CRC) from both tumorous and non‐tumorous areas were collected during hepatic resection surgery. They were evaluated by immunohistochemical analyses of hematoxylin–eosin, Masson's trichrome, NRF2, and KEAP1, and compared with clinicopathological information.ResultsHepatic inflammation and fibrosis were more severe in the low‐intensity NRF2 group than in the high‐intensity NRF2 group both between CRC and NASH (Low vs. High: inflammation; p = 0.003, fibrosis; p = 0.014), and between CRC and CHc (Low vs. High: inflammation; p = 0.031, fibrosis; p = 0.011), which could indicate that NRF2 expression in cytosol of hepatocytes was inversely correlated with liver inflammation and fibrosis in non‐tumorous areas. The dense staining of NRF2 in the nuclei of non‐tumor hepatocytes positively correlated with liver inflammation (CRC and NASH; R = 0.451, p < 0.001, CRC and CHc; R = 0.502, p < 0.001) and fibrosis (CRC and NASH; R = 0.566, p < 0.001, CRC and CHc; R = 0.548, p < 0.001) in both NASH and CHc, and was inversely correlated with hepatic spare ability features such as platelet count (R = −0.253, p = 0.002) and prothrombin time (R = −0.206, p = 0.012). However, KEAP1 expression was not correlated with NRF2 expression levels and nuclear staining intensity.ConclusionsNuclear translocation of NRF2 was correlated with the magnitude of liver inflammation and fibrosis in chronic liver disease. These results suggest that NRF2 plays a protective role in the development of chronic liver diseases such as NASH and CHc.
Comparison of the slow‐pull and aspiration methods of endobronchial ultrasound‐guided transbronchial needle aspiration for next‐generation sequencing‐compatible tissue collection in non‐small cell lung cancer
Authors: Kajita Yukihito , Teranishi Shuhei , Sawazumi Tomoe , Watanabe Haruka , Nagaoka Satoshi , Tanaka Anna , Suzukawa Yuichirou , Motobayashi Yuto , Hirose Tomofumi , Maeda Chihiro , Seki Kenichi , Tashiro Ken , Kobayashi Nobuaki , Yamamoto Masaki , Kudo Makoto , Inayama Yoshiaki , Kaneko Takeshi 
Published: September 2023

AbstractBackgroundPersonalized treatment for non‐small cell lung cancer (NSCLC) has advanced rapidly, and elucidating the genetic changes that trigger this disease is crucial for appropriate treatment selection. Both slow‐pull and aspiration methods of endobronchial ultrasound‐guided transbronchial needle aspiration (EBUS‐TBNA) are accepted methods for collecting samples suitable for next‐generation sequencing (NGS) to examine driver gene mutations and translocations in NSCLC. Here, we aimed to determine which of these two methods is superior for obtaining higher‐quality samples from patients with NSCLC.MethodsSeventy‐one patients diagnosed with NSCLC via EBUS‐TBNA using the slow‐pull or aspiration (20‐mL negative pressure) methods between July 2019 and September 2022 were included. A total of 203 tissue samples from the 71 patients were fixed in formalin, embedded in paraffin, and mounted on slides. The presence of tissue cores, degree of blood contamination, and number of tumor cells were compared between the groups. The success rate of NGS, using Oncomine Dx Target Test Multi‐CDx, was also compared between the groups.ResultsThe slow‐pull method was associated with a higher yield of tissue cores, lower degree of blood contamination, and higher number of tumor cells than the aspiration method. The success rate of the NGS was also significantly higher for the slow‐pull group (95%) than for the aspiration group (68%).ConclusionOverall, these findings suggest that the slow‐pull method is a superior technique for EBUS‐TBNA to obtain high‐quality tissue samples for NGS. The slow‐pull method may contribute to the identification of driver gene mutations and translocations and facilitate personalized treatment of NSCLC.
Heterogeneous group path planning algorithm based on data and mechanism model
Authors: Li Chaochao , Wu Qiong 
Published: September 2023

AbstractIt is a challenging task to find a feasible path from the start to the end for heterogeneous group and avoid collision between dynamic agents and static obstacles. The existing methods are usually applicable to static simple scenes or the type of scenes including a single kind of agents, and it is difficult to meet the high dynamic heterogeneous group movements. To address the above issues, we propose a hybrid driven heterogeneous group path planning method based on data and mechanism model. Data and mechanism model are combined to drive movements of heterogeneous groups. The experimental results show that our method can describe movements of heterogeneous groups more realistically and solve the collision avoidance of heterogeneous groups well. We quantitatively evaluate our method using metrics such as the number of inflection points and the average turning angle. Average turning angle has decreased by 59.50% on average over prior methods. Number of inflection points has decreased by 69.19% on average over prior methods.
Novel approach to stenting the left anterior descending coronary artery through a retrograde approach via the left internal mammary artery graft in a patient with occlusion of the coronary ostium from a prior aortic valve replacement
Authors: Soud Mohamad , Feit Frederick , Rao Sunil , Bangalore Sripal 
Published: September 2023

AbstractTotal occlusion of both coronary ostia is a rare and potentially life‐threatening complication following surgical aortic valve replacement. This report presents a case of a patient with known total occlusion of both coronary artery ostia following combined coronary artery bypass graft surgery and aortic valve replacement who underwent successful percutaneous coronary intervention through a retrograde approach.
Parasitic mature cystic ovarian teratoma: A rare case of autoimplantation of a twisted dermoid cyst
Authors: Shrestha Suraj , Adhikari Sugat , Yadav Chandra Narayan , Poddar Elisha , Bhatta Shekhar , Sapkota Surendra , Khadayat Ramesh , Neupane Garima , Kunwar Simin , Regmi Pradeep Raj 
Published: September 2023

Key Clinical MessageExtragonadal parasitic dermoid cysts are rare. Diagnosis of such extragonadal parasitic teratoma is often done intraoperatively during surgical exploration of abdominal mass.