bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tissue and Circulating MicroRNA-31, MicroRNA-200b, and MicroRNA-200c Reflects Disease Activity in Crohn‘s Disease Patients: Results from the BIOMIR Study
Authors: Tocia Cristina , Dumitru Andrei , Mateescu Bogdan , Negreanu Lucian , State Monica , Cozaru Georgeta Camelia , Mitroi Anca Florentina , Brinzan Costel , Popescu Razvan , Leopa Nicoleta , Iordache Miorita Melina , Manea Mihaela , Matei Elena , Dumitru Eugen , Alexandrescu Luana 
Published: March 2023

Background and Aims: MicroRNAs (miR) have altered expression in multiple autoimmune disorders including inflammatory bowel disease. The aim of the study was to assess the tissue and circulating miR-31, miR-200b, and miR-200c expression levels as potential biomarkers for intestinal disease activity in patients with Crohn’s disease (CD).
Methods: The study included 45 patients with histopathological confirmed CD and active disease (defined as fecal calprotectin >50 μg/g and Simple Endoscopic Score (SES) of CD >3), and 21 subjects as controls for the validation cohort. Demographic and clinical data, biomarkers (fecal calprotectin), endoscopy data, the expression levels of miR-31, miR-200b, and miR-200c in tissue and serum were assessed (by RT-PCR). Receiver operating characteristic analysis was performed to assess the miR-31, miR-200b, and miR-200c expression levels as potential biomarkers for active CD.
Results: Mean fecal calprotectin was 1540±890 μg/g. Mean SES-CD was 8.9±4.2. Tissue and circulating miR- 31 were significantly correlated with fecal calprotectin (r=0.81, r=0.83, p<0.01) and with SES-CD (r=0.82, r=0.79, p<0.01). The expression level of miR-31 was significantly upregulated in CD tissue cases compared to the control tissue samples (6.24±1.57 vs. 3.70±1.44; p <0.01). Similarly, serum miR-31 expression levels in CD patients were significantly upregulated compared to the control serum samples (0.78±0.42 vs. -2.07±1.00; p<0.01). The expression levels of tissue miR-200b and miR-200c were significantly upregulated in CD tissue cases compared to the control tissue samples (-5.25±0.93 vs. -4.69±0.80, p=0.03 for miR-200b, and -0.86±0.96 vs. 0.39±0.66, p<0.01 for miR-200c). Similarly, serum miR-200b and miR-200c expression levels in CD patients were significantly upregulated compared to the control serum samples (p < 0.05). Receiver operating characteristic analysis revealed that the expression levels of the selected miRNAs could help to discriminate active CD patients from healthy controls with very good specificity and sensitivity.
Conclusions: Tissue and circulating miR-31, miR-200b, and miR-200c reflect disease activity in CD patients and can be used as biomarkers for active disease.
Applications of Artificial Intelligence in the Automatic Diagnosis of Focal Liver Lesions: A Systematic Review
Authors: Popa Stefan Lucian , Grad Simona , Chiarioni Giuseppe , Masier Annalisa , Peserico Giulia , Brata Vlad Dumitru , Dumitrascu Dinu Iuliu , Fantin Alberto 
Published: March 2023

Background and Aims: Focal liver lesions (FLLs) are defined as abnormal solid or liquid masses differentiated from normal liver, frequently being clinically asymptomatic. The aim of this systematic review is to provide a comprehensive overview of current artificial intelligence (AI) applications, deep learning systems and convolutional neural networks, capable of performing a completely automated diagnosis of FLLs.
Methods: We searched PubMed, Cochrane Library, EMBASE, and WILEY databases using predefined keywords. Articles were screened for relevant publications about AI applications capable of automated diagnosis of FLLs. The search terms included: (focal liver lesions OR FLLs OR hepatic focal lesions OR liver focal lesions OR liver tumor OR hepatic tumor) AND (artificial intelligence OR machine learning OR neural networks OR deep learning OR automated diagnosis OR ultrasound OR US OR computer scan OR CT OR magnetic resonance imaging OR MRI OR computer-aided diagnosis OR automated computer tomography OR automated magnetic imaging).
Results: Our search identified a total of 32 articles analyzing complete automated imagistic diagnosis of FLLs, out of which 14 studies analyzing liver ultrasound images, 8 studies analyzing computer tomography images and 10 studies analyzing images obtained from magnetic resonance imaging.
Conclusions: We found significant evidence demonstrating that implementing a complete automated system for FLLs diagnosis using AI-based applications is currently feasible. Various automated AI-based applications have been analyzed. However, there is no clear evidence about the superiority of any of the systems.
A structural, optical and electrical comparison between physical vapour deposition and slot-die deposition of Al:ZnO (AZO)
Authors: Matheson Ewan D. , Xu Xinya , Qu Yongtao , Zoppi Guillaume , Barrioz Vincent , Beattie Neil S. 
Published: March 2023

AbstractAluminium-doped zinc oxide (AZO) is a potential low-cost alternative to indium tin oxide (ITO) for application in optoelectronic devices as a transparent conducting thin film. Typically, AZO thin films are deposited using expensive, high vacuum equipment with high energy cost and materials wastage. In this study, slot-die coating was used as an inexpensive alternative to vacuum deposition to form AZO nanoparticle thin films under ambient laboratory conditions. The films were characterised structurally, optically and electrically and compared with a commercially obtained AZO film fabricated using physical vapour deposition (PVD). Structural characterisation of the nanoparticle film shows uniform coverage across the substrate with increased crystal quality following annealing in Ar up to 500 $$^{\circ }$$

∘

C. The optical properties of the nanoparticle film exhibit a wider band gap than the PVD film, while the high density of grain boundary defects between the nanoparticles inhibits sheet conductivity.
Graphical abstract
Effect of foliar treatment with chitosan on phenolic composition of ῾Fetească neagră’ grapes and wines
Authors: ARTEM Victoria , ANTOCE Arina O. , GEANA Elisabeta I. , RANCA Aurora 
Published: March 2023

The objective of this study was to determine the influence of chitosan treatments, applied in vineyard for plan protection, on the phenolic quality of grapes. The study was conducted for two consecutive years (2020-2021) in the wine center of Murfatlar, Romania, on ‘Fetească neagră’, an ancient but well-known indigenous Romanian grape variety for red wines. Chitosan is meant to offer an alternative for the classic treatment with Bordeaux mixture (BM), which represented the control variant. A combination treatment with half dose of chitosan and half dose of BM was also applied and evaluated. Chemical composition at harvest time was evaluated by measuring the content of sugar, total acidity, pH, total anthocyanin potential (ApH1), anthocyanins extractable at wine pH (ApH3.2), total polyphenol index, skin tannins, seed tannins and seeds maturity. In wines the colour parameters were determined by spectrophotometry and individual phenolic compounds by UHPLC-HRMS. In grapes, accumulation of anthocyanins increased with the total dose of chitosan applied in the vineyard, with higher values in 2020 when temperatures were higher and the rainfall values were typical for the region. Accumulation of tannins in grape skins followed a similar trend. In wine, chitosan determined a significant 72% increase in colour intensity in 2020. Among the individual phenols gallic acid was predominant, with higher values in the rainier year (2021) and significant increases determined by chitosan treatment (especially in 2021 when it increased by 97% as compared to BM treatment). Catechin and epicatechin recorded important increases in the less favourable year (2021), with confirmed increases in both years elicited by the chitosan. Quercetin and myricetin were not influenced by the chitosan treatment, but their increase was correlated with higher temperatures and inversely correlated to the amount of rainfall. Trans-resveratrol ranged between 4.3-8.0 mg L-1 in 2020 and 5.0-6.5 mg L-1 in 2021, with an important increase determined by the chitosan treatment in 2020 (89% increase compared to BM treatment).
Summary of the implementation of the 12 years of hearing screening programs among first and sixth graders attending the primary schools in Warsaw
Authors: Skarżyński Piotr , Skarżyński Henryk , Świerniak Weronika , Czajka Natalia , Kochanek Krzysztof 
Published: March 2023

WstępMasowe badania przesiewowe słuchu u dzieci oparte są na koncepcji profilaktyki wtórnej. W uznaniu znaczenia wczesnej identyfikacji i interwencji u dzieci z wrodzonymi lub wcześnie nabytymi (tj. w okresie noworodkowym) zaburzeniami słuchu, na całym świecie wprowadzono liczne programy badań przesiewowych słuchu wśród noworodków. W Polsce brak jest kontynuacji tego typu programów dla dzieci w wieku szkolnym. Natomiast Instytut Fizjologii i Patologii Słuchu na zlecenie Biura Polityki Zdrowotnej Urzędu m.st. Warszawy był realizatorem programów badań przesiewowych słuchu wśród uczniów klas I i VI na terenie Warszawy. W pracy podsumowano 12 lat realizacji programów badań przesiewowych słuchu wśród uczniów rozpoczynających oraz kończących naukę w szkołach podstawowych na terenie Warszawy. Celem programów było wykrycie zaburzeń słuchu, zwiększenie świadomości wśród rodziców oraz w środowisku szkolnym w zakresie wczesnego wykrywania zaburzeń słuchu oraz możliwości wczesnej diagnostyki i terapii.Materiał i metodyUczestnikami badania było 162 193 uczniów z klas I i VI uczęszczających do warszawskich szkół podstawowych. Wyznaczono próg słyszenia na przewodnictwo powietrzne dla częstotliwości 0,5–8 kHz. Badania przesiewowe słuchu wykonano przy użyciu Platformy Badań Zmysłów.WynikiNieprawidłowy wynik badania przesiewowego stwierdzono u 13,3% badanych dzieci. Większość ubytków słuchu, tj. 67,7%, była jednostronna.WnioskiWłaściwie prowadzone działania profilaktyczne w zakresie zaburzeń słuchu wraz z edukacją zdrowotną i promocją zdrowia prowadzą w dłuższej perspektywie do minimalizowania zjawiska niepełnosprawności, a tym samym do poprawy stanu zdrowia ludności, zmniejszenia liczby osób z trwałym inwalidztwem z powodu wad słuchu oraz obniżenia kosztów leczenia. Wykorzystanie technologii informatycznych do bieżącej kontroli parametrów wpływających na jakość wykonywanych badań, przy zapewnieniu optymalnych warunków akustycznych i stosowania się do zalecanych procedur, pozwala znacząco ograniczyć liczbę wyników fałszywie
dodatnich i fałszywie ujemnych. Połączenie audiometru przesiewowego z centralnym systemem zarządzania jest optymalnym modelem w masowych badaniach przesiewowych słuchu.
Rain-fed agriculture in the steppe and forest-steppe zone of the Ural River basin and the adaptation of agricultural technologies to changing moisture availability as a way to preserve surface water resources
Authors: Gulyanov Yu. A. , Chibilev A. A. 
Published: March 2023

Aim. The aim of the research was to determine the relationship of winter wheat grain yields with meteorological parameters, the determination of the dynamics and current level and the selection and scientific justification of adaptive agricultural technologies.Material and Methods. Retrospective analysis was undertaken of meteorological conditions and gross winter wheat harvests by standard methods of correlation and regression analysis. The strength of the connection between the data of individual arrays was determined, as well as the identification of joint variation of productive and factorial features by pairwise comparison of their time series.Results. Six joint variations of time series of productive (gross grain harvest) and factorial features (hydrothermal conditions of vegetation periods and structural indicators of crops) with medium and high closeness of correlation, expressed in the form of multiple regression equations, were revealed.Conclusion. The results of the studies indicate a close direct relationship between gross grain harvest and yield from the harvesting area (r = 0.79), which in turn is inversely dependent (to an average degree) on the sum of the active air temperatures of the entire period from sowing to harvesting (r = 0.64). Из осадков различных периодов вегетации преимущественное прямое влияние на урожайность зерна оказывают осадки холодного периода года (r = 0.49) и всего активного периода вегетации от начала парования до уборки (r = 0.39). Of the precipitation of different periods of vegetation, the predominant direct effect on grain yield is exerted by precipitation during the cold period of the year (r = 0.49) and the entire active period of vegetation from the beginning of fallow to harvest (r = 0.39). The effect of amounts of precipitation for certain short periods of vegetation is much lower. Under current conditions, the stability of winter wheat grain production will be determined by the adaptability of agricultural technologies to the increasing aridity of the climate, which significantly worsens the moisture supply of plants.
Most recent composition of the ornithofauna of the Middle Irtysh region, Russia
Authors: Marhaev A. G. , Soloviev S. A. , Soloviev F. S. , Alekseev A. Yu. 
Published: March 2023

Aim. The work was to compile a list of bird species and their status in the forest-steppe and steppe of the Middle Irtysh region at the present time and to analyse their potential ability in terms of the transmission of influenza viruses that pose a danger to humans and farm animals.Materials and Methods. The study of avifauna and their status in the forest-steppe and steppe of the Middle Irtysh region has been conducted by us from 1973 to the present. The analysis of literary sources has been carried out since the time of P.S. Pallas's travels in the region in 1871. In addition, information on the wetlands of the Irtysh region which is freely available on the Internet was used.Results. At the beginning of the 20th century, about 200 species of birds were recorded in the vicinity of Omsk, 125 of them being breeding species. At present about 150 species of birds have been recorded in Omsk and its environs. Of the 290 bird species of the Middle Irtysh region, 48 species (16.6%) belong among the natural hosts of influenza A viruses. Of these, at least 40 species are migratory and 25 species nest there. In addition to the prinicipal influenza virus host species, the list of birds of the Middle Irtysh region includes several species of scavengers and predators, as well as synanthropic bird species. These species may share habitat or food resources with the main host species of influenza viruses. Influenza A viruses can be transmitted between species either by direct or indirect contact through mechanical propagation or contamination of nutritional resources.Conclusion. As the 3 largest bird migratory flyways run through the Middle Irtysh region where there is a significant number of wetlands, the prerequisites are created for a mass simultaneous accumulation of different populations and species of migratory birds carrying viruses and, accordingly, a high probability of exchanging viral genomes with each other and their further spread to new regions.
Factors associated with oral health relatedquality of life in preschoolers from an Andean community
Authors: Huamán Mendoza Aldrin A. , Pinedo Tellez Karen S. , Rodrigues de Almeida Silva Carla , Tello Guerrero Yvette G. , Calle Lopez Patricia , García Rupaya Carmen R. , Valdez Jurado Freddy R. 
Published: March 2023

Objetivo: Analizar el estado de salud bucal y su relación con la calidad de vida de los preescolares de una comunidad andina y vulnerable del Perú. Material y Métodos: El estudio observacional, correlacional y transversal se realizó en una muestra de 120 niños de 3 a 5 años. La caries de la primera infancia se determinó mediante el índice ceod. También se consideró la presencia y el tipo de maloclusión. El cuestionario Early Childhood Oral Health Impact Scale (ECOHIS) midió la calidad de vida relacionada con la salud bucal. Los factores y variables orales se analizaron de manera univariada y bivariada. Se realizó un análisis de correlación de Spearman y regresión lineal para identificar los factores y en qué medida explicaban la puntuación del cuestionario. Resultados: El análisis de regresión lineal múltiple por el método de mínimos cuadrados solo incluyó como significativa (p <0,05) la contribución de ceod para explicar la puntuación del cuestionario, dejando de lado variables como el sexo, la edad, la maloclusión y el índice de higiene bucal simplificado. El modelo de regresión estimado fue Puntuación del Cuestionario = 11,67 + 0,79*ceod, donde la puntuación del cuestionario aumentó en 0,79 por cada unidad ganada de ceod, y la variabilidad de las puntuaciones obtenidas se explica por el ceod en un R2 = 30% (p<0,001). Conclusiones: Existe un impacto de la caries dental en la calidad de vida de los preescolares de uma comunidade andina del Perú y sus familias.
Factors Affecting Burnout and Turnover Intention of Nurse at Academic Hospitals in Covid 19 Pandemic
Authors: Mafula Dluha , Retno Martani Hersinta , Widyawati Widyawati 
Published: March 2023

Introduction: The COVID-19 has caused an increase in workload that affects the physical and psychological health of nurses. Moreover, the ongoing increase of workload can trigger work fatigue and declining work motivation. The purpose of this research is to identify factors which influence burnout and turnover intention of nurses working in a academic hospital during the COVID-19 pandemic.
Method: This research is non-experimental explanation survey research with cross sectional approach which involved 186 respondents who are chosen using convenience sampling. The independent variables are demographic factors while the dependent variables are burnout and turnover intention. Instrument used is a questionnaire related burnout and turnover intention which is based on a reference of earlier research. Data analysis used is multiple regression and logistic with p value ≤ 0,05.
Result: Indicators influencing burnout were age (Coeff: -0.017; p=0.017), family dependents (Coeff: -0.799; p=0.011), and workshop on COVID-19 management (Coeff: 0.869; p=0.017). Indicators influencing turnover intention were family dependents (Coeff: -0,647; p=0.014), marital status (Coeff: 1.589; p=0.000), adjustment and arrangement of work schedule for COVID-19 service (Coeff: 0,901; p=0.033), and workshop on COVID-19 management (Coeff: 0,901; p=0.020).
Conclusion: The research shows that turnover intention on nurses working in a academic hospital during the COVID-19 pandemic is mostly on moderate level, as well as with burnout. Health institutions must focus on applying strategies to reduce a nurse workload which include infection prevention action, personal protective equipment (PPE), regular workshops on current COVID-19 management, incentive allotment punctuality and flexible work schedule arrangement.
Pengembangan Media Pembelajaran Pull Out Photo Box Sebagai Upaya Peningkatan Pemerolehan dan Pembelajaran Bahasa Bagi Anak Berkebutuhan Khusus (ABK) Pada Sekolah Inklusi Tingkat Dasar
Authors: Wisnu Wardana Muhammad Aditya , Febriana Noerzada , Krida Karina Yiyin , Mulyono Slamet , Sasmito Edy 
Published: March 2023

Proses pemerolehan dan pembelajaran bahasa bagi penyandang tunarunggu di sekolah inklusi perlu dilakukan sebagai upaya menjamin pendidikan peserta didik yang belajar pada kelas inklusi. Pada saat ini Indonesia juga telah mempunyai UU tentang kesetaraan disabilitas di berbagai fasilitas publik dan tempat, yaitu pada Undang-Undang Nomor 8 tahun 2016. Salah satu sekolah inklusi di Indonesia adalah SDN 3 Kepanjenlor Kota Blitar. Tujuan dari pengembangan media pembelajaran pull out photo box adalah salah satu upaya peningkatan pemerolehan dan pembelajaran bahasa bagi anak berkebutuhan khusus (ABK) pada sekolah inklusi tingkat dasar. Pengembangan media pembelajaran pull out photo box dilakukan dalam 4 tahapan yaitu (1) tahap define (pendefinisian); (2) tahap design (perancangan); (3) tahap development (pengembangan); (4) dan tahap testing (percobaan). Penelitian ini dilakukan dengan mengambil sampel dari pendidik dan peserta didik di SDN 3 Kepanjenlor Kota Blitar Provinsi Jawa Timur dengan mengajukan pertanyaan kepada salah satu guru pendidik bahasa melalui media zoom meeting dan siswa melalui google form untuk mengetahui pemahaman serta kepuasan dalam menggunakan media pembelajaran pull out photo box dalam pembelajaran bahasa. Hasil yang diperoleh pada penelitian tersebut didapatkan sebuah kesimpulan yang memuaskan dalam menggunakan media pembelajaran pull out photo box di kelas inklusi tingkat dasar yaitu siswa mampu memahami materi pembelajaran bahasa serta tertarik dan aktif untuk mengikuti pembelajaran dengan menggunakan media pembelajaran tersebut.
Kata-kata kunci: Media Pembelajaran, Sekolah Inklusi, Pembelajaran, Pendidikan
Evaluasi Program Pendidikan Pengembangan Spesialisasi Bintara Dasar Intelijen (Densus 88 AT)
Authors: Mahany Yusdan Ibnuza , Suryadi Suryadi , Sutomo Sugiarto 
Published: March 2023

Penelitian ini bertujuan untuk mengetahui dampak program Dikbangspes bagi peserta didik dan instansi tempat peserta didik bekerja, melalui pendekatan pendekatan kualitatif yang berupaya untuk mengungkapkan secara deskriptif terhadap evaluasi program sehingga memperoleh data yang objektif untuk menilai ketercapaian program Dikbangspes Bintara Dasar Intelijen (Densus 88 AT). data dan informasi berupa hasil wawancara, kuisoner, studi dokumentasi, analisis dokumen tentang program Pendidikan Pengembangan Spesialisasi Bintara dasar intelijen (Densus 88 AT) Di Pusdik Intelkam Lemdiklat Polri akan diolah dan disajikan secara deskriptif dengan melakukan analisis menggunakan prosedur berdasarkan 4 (empat) tahapan evaluasi Kirkpatrick program yang meliputi evaluasi: reaksi, pembelajaran, perilaku, dan hasil. Tahap Evaluasi Reaksi (Reaction) : Pada komponen kurikulum, secara umum peserta menyatakan kepuasan dengan kurikulum Dikbangspes ini.. Perlu adanya integrasi antara teori dengan praktik. Hasil evaluasi reaksi (reaction) dari peserta Dikbangspes secara umum dinyatakan telah memenuhi kriteria ketercapaian evaluasi program program Dikbangspes membawa perubahan perilaku bagi pesertanya. Evaluasi atas hasil (result) evaluasi atas hasil (result) Dikbangspes telah memenuhi kriteria penelitian. Implikasi dari penelitian ini perlu Mengevaluasi pengelolaan Dikbangspes untuk masa mendatang (2) Mengevaluasi secara berkala setiap perkembangan peserta didik baik dalam aspek kognitif, afektif, psikomotorik, fisik maupun psikologis peserta. Di era pandemi ini hal tersebut sangat penting karena sisi psikologis tentu akan berdampak pada penyerapan materi pembelajaran Dikbangspes
First experimental tests on the prototype of a capacitive oil level sensor for aeronautical applications
Authors: Attivissimo Filippo , Adamo Francesco , De Palma Luisa , Lotano Daniel , Di Nisio Attilio 
Published: March 2023

In this paper, the design, the prototyping, and the first experimental tests of a Capacitive Oil Level Sensor (CLS) intended for aeronautical applications are described. Due to potentially high vibrational stresses and the presence of high electromagnetic interferences (EMI), the working conditions on aircraft can be considered quite harsh. Hence, both the sensing part and the conditioning circuit should meet strict constraints. For this reason, in the design phase, great attention has been paid also to the mechanical characteristics of the probes. All the design aspects are exposed and the main advantages concerning alternative level sensing techniques are discussed and the preliminary experimental results of sensitivity, linearity, hysteresis, and settling time tests are presented and commented.