bluuebunny/crossref_metadata_2025_split huggingface dataset:
Temporal modelling of long-term heavy metal concentrations in aquatic ecosystems
Authors: Bushra Basmah , Bazneh Leyla , Deka Lipika , Wood Paul J. , McGowan Suzanne , Das Diganta B. 
Published: June 2023

Abstract

This paper examines a series of connected and isolated lakes in the UK as a model system with historic episodes of heavy metal contamination. A 9-year hydrometeorological dataset for the sites was identified to analyse the legacy of heavy metal concentrations within the selected lakes based on physico-chemical and hydrometeorological parameters, and a comparison of the complementary methods of multiple regression, time series analysis, and artificial neural network (ANN). The results highlight the importance of the quality of historic datasets without which analyses such as those presented in this research paper cannot be undertaken. The results also indicate that the ANNs developed were more realistic than the other methodologies (regression and time series analysis) considered. The ANNs provided a higher correlation coefficient and a lower mean squared error when compared to the regression models. However, quality assurance and pre-processing of the data were challenging and were addressed by transforming the relevant dataset and interpolating the missing values. The selection and application of the most appropriate temporal modelling technique, which relies on the quality of available dataset, is crucial for the management of legacy contaminated sites to guide successful mitigation measures to avoid significant environmental and human health implications.
Novel Approach for the Synthesis of 2, 5-disubstituted 1, 3, 4-thiadiazoles
from Benzothiohydrazides and Ethylbenzimidate
Authors: S Shobha , Kemparajegowda  , Girimanchanaika Swamy Savvemala , Swarup Hassan A. , Mantelingu Kempegowda 
Published: June 2023

Abstract:
In the current study, a simple and reliable technique for the synthesis of 2,5-disubstituted
1,3,4-thiadiazoles from ethylbenzimidate and benzothiohydrazides were devised. This protocol goes
via a base-mediated nucleophilic addition elimination process, followed by intramolecular rearrangement.
Our method utilizes commonly accessible and non-toxic substrates and a simple workup procedure
to produce high to exceptional yields (70-91%) of 2,5-diphenyl 1,3,4-thiadiazoles derivatives
with a wide range of substitutions. We present a simple procedure for the synthesis of 1, 3, 4-
thiadiazole using ethylbenzimidate and benzothiohydrazides in the presence of Et3N in DMSO solvent
as affordable and easily accessible starting materials to create derivatives under ambient conditions.
Metal-based Ionic Liquids and Solid-loaded Catalysts in Fuel Oil Desulfurization:
A Review
Authors: Niu Anqi , Xu Hang , Yuan Qinlin , Wu Fengmin , Wei Xuefeng 
Published: June 2023

Abstract:
Metal-based ionic liquids (MILs) have the advantages of designability, efficiency, stability,
and regenerative cycle and can efficiently convert thiophene and its derivatives, which are important
for the production of "ultra-low sulfur" oils. This paper provides an overview of the research progress
of MILs in the field of fuel desulfurization, focusing on the current status of MILs and solid-loaded
MILs catalysts in extractive desulfurization, oxidative desulfurization, extraction-catalyzed oxidative
desulfurization, and catalytic-adsorption desulfurization processes. For MILs, the anion and cation
can be altered by design so as to impart specific functions. Loading is one of the effective ways to solidify
MILs, and the combination of MILs with different carriers can not only reduce the usage while
ensuring the catalytic activity but also improve the reusability of the catalyst. The combination of
MILs with specially structured carriers also allows solution-free adsorption and removal of oxidation
products. Compared with conventional MILs, polymetallic-based ionic liquids (PMILs) exhibit ultrahigh
catalytic activity and are one of the most promising materials available, but are still in their infancy
in the field of fuel catalysis, and researchers are needed to enrich the gap in this field. Finally,
some problems faced by various types of MILs are pointed out in order to design new functional
MILs catalysts with better properties in the future and promote the further development of MILs in
the field of fuel catalysis.
Development of a Suitable HPLC Method for the Analysis of Impurities in
Clorprenaline and Bromhexine Capsules and Identification of Unknown
Impurities by 2D LC-Q-TOF MS
Authors: Shi Yunfeng , Lin Liqin , Yao Qi , Ren Xiaojuan , Zhang Fengmei 
Published: June 2023

Background:
Impurities may reduce antibacterial activity and affect clinical efficacy,
However, there has been no report on the impurity of clorprenaline and bromhexine capsules.

Objective:
In order to determine the impurities in compound clorprenaline and bromhexine capsules.

Methods:
A new stability-indicating HPLC method was established. A Boston Green ODS column
was used, and the UV detection was 225nm.

Results:
The established method was highly specific, sensitive, accurate, and suitable for routine
quality control of clorprenaline and bromhexine capsules. The structures of unknown impurities
were characterized by the MS/MS data.

Conclusion:
These results provide a sufficient basis for our subsequent study on the safety of
Compound Clorprenaline and Bromhexine Capsules and also provide ideas for the impurity research
of other compound preparations.
A Routine over the Counter Phenylephrine Causing Rarer Drug Eruption
as Adverse Drug Reaction - A Case Report
Authors: Yella Sree Sudha Tanguturi , Krishna Sasanka Kota Sesha Brahma Sri , Singh Harminder , Meena Bhumika 
Published: June 2023

Background:
Phenylephrine is a sympathomimetic, which means it acts analogous to
adrenaline. Phenylephrine can be taken orally to treat nasal congestion symptoms. It is also frequently
mixed with other medicines in products meant to relieve cough and cold symptoms. Given
the widespread usage of phenylephrine, related drug eruptions appear to be uncommon.

Case Presentation:
Here we discuss a case of a 19-year-old female patient who reported to our
hospital with blebs on the skin throughout her legs and torso. The drug eruption or adverse drug
response was linked with itching, had a slow beginning, and progressed. Her medical history indicated
that she had been taking phenylephrine 10 mg orally twice a day. On the sixth day, she experienced
an adverse medication response caused by the medicine phenylephrine. Phenylephrine was
stopped immediately and the other medications, such as levocetirizine, montelukast, and nasal
spray, were continued. The patient was told not to use phenylephrine, either alone or in combination
with FDCs. There are no other complaints. As a result, the patient was diagnosed with phenylephrine-
induced eruption.

Conclusion:
We present this case to highlight the importance of inspiring a pharmacovigilance
mindset among all clinicians providing care as a routine alert drug, phenylephrine-induced drug eruption.
Parametric Analysis of Indium Gallium Arsenide Wafer-based Thin Body
(5 nm) Double-gate MOSFETs for Hybrid RF Applications
Authors: Paramasivam Pattunnarajam , Gowthaman Naveenbalaji , Srivastava Viranjay. M. 
Published: June 2023

Introduction:
The electrical behavior of a high-performance Indium Gallium Arsenide (In-
GaAs) wafer-based n-type Double-Gate (DG) MOSFET with a gate length (LG1= LG2) of 2 nm was analyzed.
The relationship of channel length, gate length, top and bottom gate oxide layer thickness, a gate
oxide material, and the rectangular wafer with upgraded structural characteristics and the parameters,
such as switch current ratio (ION/IOFF) and transconductance (Gm) was analyzed for hybrid RF applications.

Methods:
This work was carried out at 300 K utilizing a Non-Equilibrium Green Function (NEGF)
mechanism for the proposed DG MOSFET architecture with La2O3 (EOT=1 nm) as gate dielectric oxide
and source-drain device length (LSD) of 45 nm. It resulted in a maximum drain current (IDmax) of 4.52
mA, where the drain-source voltage (VDS) varied between 0 V and 0.5 V at the fixed gate to source
voltage (VGS) = 0.5 V. The ON current(ION), leakage current (IOFF), and (ION/IOFF) switching current ratios
of 1.56 mA, 8.49Í10-6 μA, and 18.3Í107 μA were obtained when the gate to source voltage (VGS)
varied between 0 and 0.5 V at fixed drain-source voltage (VDS)=0.5V.

Results:
Results: The simulated result showed the values of maximum current density (Jmax), one and twodimensional
electron density (N1D and N2D), electron mobility (μn), transconductance (Gm), and Subthreshold
Slope (SS) are 52.4 μA/m2, 3.6107 cm-1, 11.361012 cm-2, 1417 cm2V-1S-1, 3140 μS/μm,
and 178 mV/dec, respectively.

:
The Fermi-Dirac statistics were employed to limit the charge distribution of holes and electrons at a
semiconductor-insulator interface. The flat-band voltage (VFB) of - 0.45 V for the fixed threshold voltage
greatly impacted the breakdown voltage. The results were obtained by applying carriers to the
channels with the (001) axis perpendicular to the gate oxide. The sub-band energy profile and electron
density were well implemented and derived using the Non-Equilibrium Green’s Function (NEGF) formalism.
Further, a few advantages of the proposed heterostructure-based DG MOSFET structure over
the other structures were observed.

Conclusion:
This proposed patent design, with a reduction in the leakage current characteristics, is
mainly suitable for advanced Silicon-based solid-state CMOS devices, Microelectronics, Nanotechnologies,
and future-generation device applications.
Micellar Effect on the Oxidation of Anisaldehyde by Quinolinium
Dichromate in Aqueous Acidic Media: A Kinetic Study
Authors: Yadav Manju Bala , Meena Manju , Meena Bharat Singh , Meena Kamini 
Published: June 2023

Aims:
Oxidation of p-anisaldehyde by Quinolinium dichromate (QDC) in the
aqueous acetic acid medium in the presence of sulphuric acid using surfactants.

Background:
The oxidation studies of anisaldehyde is very important as the oxidized
products are used as a synthetic intermediate for the preparation of a variety of drugs.
Quinolinium dichromate (QDC) has emerged as a very useful and versatile oxidant.
Micellar medium enhances the reaction rate.

Objective:
1. To study the kinetics of the reaction, which includes the determination of
order, rate, and activation parameters. 2. Spectral characterization of QDC by NMR and
the kinetic study of the reaction mechanism is done through UV – A visible
spectrophotometer. 3. Solvent effect for the oxidation of anisaldehyde by QDC. 4.
Determination of critical micelle concentration (CMC) of used surfactants (CTAB and
SDS).

Methods:
The reactions were followed at constant temperature and were followed by
monitoring the UV – Visible spectrophotometer (Double Beam – 2203) in a quartz cuvette
of 1 cm path length by following the absorbance decay of Cr (VI) at 440 nm.

Result:
KINETIC RESULTS: 1. The reaction follows first-order dependence on panisaldehyde
and QDC. 2. The reaction is found to be acid-catalysed. A plot of log [k]
versus log [H+] was found to be a straight line with a slope of 1.07. EFFECT OF
SOLVENT: The rate of reaction increases with the increase in acetic acid proportion in the
medium, which suggests that the reactions were of the ion–dipole type. MICELLAR
EFFECT: 1. Experimental results demonstrated that anionic surfactant SDS catalysed and
accelerated the study more effectively than CTAB, which is a cationic surfactant, and the
rate of reaction increases with an increase in the concentration of the SDS while in the case
of CTAB, the rate decreases with an increase in its concentration. 2. CMC values of CTAB
and SDS were 3.9 mM and 8.2 mM, respectively.

Conclusion:
The value of negative ΔS (entropy of activation) and positive ΔH (enthalpy of
activation) suggests the formation of more ordered activated complexes, and the transition
state is highly solvated. SPECTROSCOPIC ANALYSIS 1.NMR characterisation of
synthesised QDC shows a resemblance with pure QDC. 2. Effect of oxidant QDC, panisaldehyde
and acid was studied by considering the spectra of the reaction mixture and
varying their concentration.
A New Effective Strategy for User Association in Heterogeneous Networks
Authors: Aziz Layla , El Gourari Abdelali , Achki Samira 
Published: June 2023

Introduction:
Heterogeneous networks (HetNet) represent a promising technology that satisfies
the needs of mobile users. However, several problems have influenced the performance of wireless
communication, such as the maximization of energy efficiency and the problem of interferences
due to the uncontrolled association of the user equipment (UE).

Methods:
Solving the problem of maximizing energy efficiency has captured the attention of several
researchers. In this work, we propose an effective user association based on K-nearest Neighbors
(KNN) approach considering a large dataset. The major novelty of this work is that the supervised
learning perspective is applied to a dataset regrouped from an optimal user association, where the
most valuable parameters are considered.

Results:
Additionally, it allows for mitigating the problem of interferences using individual user association.
Simulation results have proven the efficiency of the proposed methodology.

Conclusion:
The suggested results have outperformed the two works in terms of accuracy, where the
proposed method presents a better accuracy of 95%.
Metronidazole Induced Cutaneous Adverse Drug Reaction- A Systematic
Review of Descriptive Studies
Authors: Taj Shifa , Zuber Mohammed , Hanumanthaiah Vidhyashree Ballagere , Venkataraman Rajesh , Puttegowda Sathish Kumar , Afrid Syed , Kiran Sai 
Published: June 2023

Background:
A substantial number of research studies on metronidazole-related cutaneous
symptoms have recently been published. Our objective was to identify and evaluate descriptive studies
that described metronidazole-related skin manifestations, therapeutic interventions, and consequences.

Methods:
A comprehensive literature search was carried out in the PubMed, Scopus, and grey literature
databases from inception to April 2022 without any constraints, as well as a snowball search in
Google and a search in Google Scholar. Descriptive articles describing metronidazole-related cutaneous
manifestations were considered for the review. Two distinct reviewers carried out the research selection,
data extraction, and quality assessment; any discrepancies were resolved by consensus with
the third reviewer.

Results:
About 24 out of 4648 descriptive studies, including 26 patients (20 Female patients and 6
male patients), were included in this review. The included studies comprised a range of ages from 16
to 78 years old. Metronidazole was indicated for the treatment of bacterial vaginosis, trichomoniasis,
sepsis, anti-infection therapy, perforated appendicitis, rosacea, vaginal discharge, dysentery, acne
rosacea, trichomonal vaginitis, lichen planus, liver abscess, facial rosacea, intestinal amoebiasis, and
gingivitis. Fixed drug eruption was the most common skin manifestation which was reported in 7 cases
included in this review. Cutaneous manifestations were ameliorated by cessation of the offending
drug and by apportioning antihistamines, topical steroids, parenteral corticosteroids, emollients, and
topical moisturizers.

Conclusion:
Clinicians and healthcare professionals should be cognizant of the potential cutaneous
adverse drug reactions (CADRs) induced by metronidazole to mitigate fatal circumstances. The management
of the CADRs appears to respond effectively with immediate drug discontinuation and supportive
therapy.

Prospero No:
CRD42021259364
LA IMPORTANCIA DEL LIDERAZGO EN LAS INSTITUCIONES
Authors: Miño Razo Jhon 
Published: June 2023

Un desafío de la gestión de los recursos humanos en toda organización es analizar las prácticas de liderazgo. Considerando que una de las tareas más difíciles de un líder es el manejo del elemento humano, ya que en él se conjugan un sin número de aristas, las cuales debe considerar el líder a fin de conseguir la armonía en el trabajo, un trabajo en equipo y sobre todo la entrega a los objetivos de la organización. Este escrito tiene por objetivo, orientar dicho análisis desde el enfoque de las organizaciones, considerando los comportamientos y actitudes necesarias para ejercer el liderazgo de manera efectiva, cimentados en valores y principios. De igual forma explora de manera general los tipos de liderazgo que se consideran más importantes o que se presentan con mayor frecuencia, pero que tienen un impacto en las organizaciones, sus aplicaciones de acuerdo con las características de la organización, mostrando de forma breve sus connotaciones e impacto en la dinámica organizacional.
Así mismo los valores capitales que se considera que debería poseer una persona que quiere ejercer el liderazgo principalmente en las organizaciones militares, en las cuales la jerarquía y la disciplina podrían verse amenazadas ante la falta de liderazgo.
The right to transplantation as a personal non-property right
Authors: Zborivskyi Y.-A. 
Published: June 2023

The article examines the concept of personal non-property benefits and their place in civil law, emphasizing the importance of personal non-property rights as absolute rights. In particular, the author analyzes the right to transplantation in the context of the exercise of personal non-property rights, examines its legal, medical and ethical aspects, and highlights the problems associated with its implementation.
Attention is drawn to the relationship between the right to transplantation and other human rights, such as the right to life, the right to medical care, and the right to health care. The article also examines the criteria that organs and anatomical materials must meet in terms of suitability for transplantation. The author analyzes the legal regime of organs and anatomical materials that can be separated from the human body and thus act as independent transplantation objects. The author emphasizes the importance of determining the list of objects that can be used as donor organs for transplantation in order to ensure the proper realization of the personal non-property right to life and health care.
The author examines the concept of informed consent of the donor and the recipient and the importance of this legal category in transplantation relations. The author outlines the key elements of informed consent, including completeness, comprehensiveness and accessibility of information, as well as voluntariness of consent. The author points out the role of healthcare professionals and their ethical and legal responsibility in ensuring that informed consent is obtained and that complete and accurate information is provided to the participants of these relationships throughout the transplantation process. The article highlights the potential negative consequences of breach of the duty to obtain informed consent, concealment or failure to provide medical information, ranging from invalidation of a contract for the provision of medical services to criminal liability.
The author analyzes the legislative acts regulating the right to transplantation, in particular, the provisions of the Civil Code of Ukraine and the Law of Ukraine «On the Application of Transplantation of Anatomical Materials a Human Being».
The administrative-procedural component of banning a political party in Ukraine
Authors: Kolesnikova M. , Shein D. 
Published: June 2023

The article is devoted to the study of the issue of the administrative-procedural component of the ban on political parties in Ukraine. The full-scale invasion of Russia became the point of extremum for intensifying measures to ensure the state and national security of Ukraine, including by disabling the activities of pro-Russian political forces. The practice of banning the functioning and activities of political parties is one of the mechanisms for protecting sovereignty and traditionally belongs to the toolkit of militant democracy.
It was emphasized that the legal basis of the procedure for banning political parties was formed relatively recently and under the influence of martial law (Law of Ukraine No. 2243-IX dated 03.05.2022 «On Amendments to Certain Legislative Acts of Ukraine Regarding the Banning of Political Parties»).
It is summarized that due to the great political and social significance that administrative cases on the banning of a political party belong to the jurisdiction of the appellate administrative court in the appellate district, which includes the city of Kyiv.
It was established that currently the legal nature of the procedure under consideration remains ambiguous in many respects, in particular, in terms of the grounds for opening proceedings and filing an administrative lawsuit to ban a political party, as well as the mechanisms of judicial review and the powers of the court when deciding such a case (regarding the ban and transfer of party property owned by the state). Administrative proceedings regarding the banning of a political party are specific and characterized by a number of various differences compared to the general principles of administrative proceedings in court. Prohibition of a political party during a court proceeding is a public process with the mandatory involvement of the Verkhovna Rada of Ukraine and the Ministry of Justice of Ukraine in the legalization of this administrative proceeding.
Administrative and legal forms of ensuring public safety and public order by the state military administrations of Ukraine under the conditions of the legal regime of martial law
Authors: Melnyk S. 
Published: June 2023

The article singles out and discloses the content of the seven main administrative and legal forms of activity of the military administrations of Ukraine regarding the provision of public safety and public order in the conditions of the legal regime of martial law. Attention is focused on the debatable understanding of the categories "public safety" and "public order".
It has been proven that military administrations solve a number of tasks in the field of ensuring public safety and public order. The practical difficulty of their implementation lies in the fact that they involve the simultaneous implementation of a complex of executive-administrative power measures. These actions are covered by the concept of "administrative-legal form". Based on the generalization of the provisions of the current legislation of Ukraine on the legal regime of martial law, the content of such forms as: general organizational activity, implementation of administrative-regime work, organization of administrative-pass regime, implementation of administrative-social work, implementation of administrative-mobilization measures, implementation of administrative and security activities, organization and implementation of information and generalization work within the framework of the implementation of measures to ensure public safety and public order.
It was noted that over the past year, Ukraine has accumulated some experience in the implementation of executive powers by military administrations, including in the sector of ensuring public safety and order. Thanks to this, the scientific community received a significant boost for critical understanding of the regulatory support of the mentioned processes. In particular, we believe that the legislative definition of public safety and public order needs to be further improved in terms of their differentiation as two related but substantively different categories. Thanks to this, the national system of military management receives the prerequisites for increasing its own potential in terms of fulfilling the tasks and functions assigned by the law.