bluuebunny/crossref_metadata_2025_split huggingface dataset:
A insegurança alimentar pela voz de adolescentes participantes do Programa Bolsa Família
Authors: Serenini Milena , Carvalho Vieira Kelly , Maciente Souza Camila , Poblacion Ana , De Aguiar Toloni Maysa Helena , De Aguiar Carrazedo Taddei José Augusto 
Published: August 2023

O trabalho busca conhecer a percepção de adolescentes, participantes do Programa Bolsa Família (PBF), sobre insegurança alimentar (IA). Trata-se de estudo de abordagem qualitativa. O corpus consiste em entrevistas com dez adolescentes e seus responsáveis. Os resultados foram analisados por meio da técnica de análise de conteúdo. Foram estabelecidas quatro categorias de análise: “A fome não é só a vontade de comer”; “O fantasma da fome”; “Um por todos e todos por um”; “Estamos seguros?” De maneira geral, os adolescentes percebem que a quantidade e variedade de alimentos mudam durante o mês e que o acesso a alimentos como frutas e carne é difícil. A preocupação com a possibilidade de o alimento faltar está presente na fala de todos os adolescentes entrevistados e se intensifica entre aqueles que vivenciaram a experiência de fome na infância. Em função disso, os adolescentes desenvolvem estratégias para o alívio da IA, para si mesmos e para suas famílias. No entanto, as responsáveis pelos adolescentes não consideram que seus filhos realmente se preocupam com a possibilidade de faltar alimentos no domicílio. Observou-se que os adolescentes percebem a situação de insegurança alimentar no domicílio e são capazes de responder de forma autônoma sobre essa situação.
Price Volatility Analysis On Indonesian Palm Oil Commodities By Model Arch/Garch
Authors: Windirah Nola , Novanda Ridha Rizki 
Published: August 2023

Abstract
Uncertainty in price movements will cause producers to find it difficult to make decisions at the time of production. One of the agricultural commodities in Indonesia that is currently the center of attention is oil palm. Agricultural Research and Development stated that Indonesian palm oil has developed into an important part of the world by occupying the first position as a producer of palm oil. The last five years have shown that palm oil price movements are quite volatile. The weakest conditions occurred in the middle of 2019 when the price of palm oil is at US$ 0.5/kg. Meanwhile, the strongest condition occurred in early 2014 at US$ 1/kg. Mistakes in making business decisions resulting from uncertain price movements will cause the potential of Indonesian palm oil in the world to decline. Through the ARCH/GARCH method, the description of price movements in Indonesian Palm Oil will be known, so that it will be easier for producers in preparing future business plans. The results showed that the ARCH (1) model was able to describe the volatility of CPO prices that occurred in Indonesia, where the forecast for CPO price volatility will be smaller in the following year. The results of this study indicate that CPO prices will be more stable and have a good impact on the CPO industry in Indonesia. These findings can be used as a basis for determining Indonesia's CPO production policy.
Keywords: ARCH/GARCH, Plam Oil, Volatility
The Effect of Snail Mucus (Achatina Fulica) on The Degree of Kidney Interstitial Fibrosis In Lupus Nephritis Mice Model
Authors: Nurudhin Arief , Adnan Zainal Arifin , Werdiningsih Yulyani , Prabowo Nurhasan Agung , Rabbani Fathina Nisa 
Published: August 2023

<p class="AbstractNormal"><strong>Introduction</strong><strong><span lang="EN-US">:</span></strong><strong></strong><span lang="IN">cytotoxic drugs dominate SLE therapy, so new therapies with minimum side effects are needed. Snail (Achatina Fulica) mucus contains two types of protein; heparan and acharan sulfate. The snail mucus has significant potential benefits, but its use in lupus nephritis has never been examined.</span></p><p class="AbstractNormal"><strong>Methods</strong><strong><span lang="EN-US">:</span></strong><strong></strong><span lang="IN">This research used an experimental model. It used mice for the experiment. The mice were divided into five groups: control, untreated lupus, standard therapy (methylprednisolone), snail mucus therapy, and a combination of standard therapy and snail mucus. Renal histology was examined at the end of the fifth month. Data were analyzed using the Shapiro-Wilk, ANOVA, and Tukey Post Hoc tests.</span></p><p class="AbstractNormal"><strong>Result</strong><strong><span lang="EN-US">s: </span></strong><span lang="EN-US">The level of interstitial fibrosis between the standard therapy group and the snail mucus group showed an MD value of -0.13 with a p-value of 1.00, meaning there is no significant difference between the level of interstitial fibrosis in the two groups. The comparison between the standard therapy group and the combination of the standard therapy group showed an MD value of 0.64 with a p-value of 0.992, which means that the combination of standard therapy tends to decrease the level of interstitial fibrosis. </span><strong><span lang="EN-US"> </span></strong></p><p class="AbstractNormal"><strong>Conclusion</strong><strong><span lang="EN-US">: </span></strong><span lang="EN-US">The administration of snail mucus in combination with standard therapy affects the decrease in the level of interstitial fibrosis in mice model lupus.</span></p>
Implementasi Nilai Toleransi dalam Pembelajaran Sejarah di SMA
Authors: Hadi Santosa Firdaus , Syafira Hana , Olivia Devi , Almaesaroh Siti 
Published: August 2023

This article aims to reveal how the value of tolerance is implemented in learning history in high school. The research method used in this research is a qualitative research method with a case study approach. The core informants in this study were history teachers and students at Dharma Karya Jakarta High School which was conducted from April to September 2021. Based on the results of the study it was found that the value of tolerance in history learning was carried out by incorporating tolerance values as a form of multicultural education, values-Multicultural values help students understand controversial material so that they can take positive lessons from a historical event. The conclusion of this study is that the value of tolerance should be applied in learning history, related to the importance of the value of tolerance in strengthening the value of
the unity of the multicultural Indonesian society.

Artikel ini bertujuan untuk mengungkapkan bagaimana nilai toleransi diimplemetasikan dalam pembelajaran sejarah di SMA. Metode penelitian yang digunakan dalam penelitian adalah metode penelitian kualitatif dengan pendekatan studi kasus. Informan inti dalam penelitian ini adalah guru mata pelajaran sejarah dan siswa di SMA Dharma Karya Jakarta yang dilakukan mulai bulan April-September 2021. Berdasarkan hasil penelitian ditemukan bahwa nilai toleransi dalam pembelajaran sejarah dilakukan dengan cara memasukkan nilai-nilai toleransi sebagai wujud pendidikan multikultur, nilai-nilai multikultural membantu siswa dalam memahami materi kontroversial, sehingga dapat mengambil pembelajaran positif dari suatu peristiwa sejarah. Kesimpulannya dalam penelitian ini adalah nilai toleransi seharusnya diterapkan dalam pembelajaran sejarah, berkaitan dengan pentingnya nilai toleransi dalam memperkuat nilai persatuan masyarakat Indonesia yang multikultur.
Enabling Hydrogen Production from Shale Oil Reservoirs: An Experimental Study Using Microwave-Assisted Catalytic Heating
Authors: Yan K. , An B. , Yuan Q. 
Published: August 2023

Abstract
Transforming hydrocarbon resources to a clean, low-cost hydrogen (H2) supplier is a promising, albeit technically difficult, pathway towards decarbonizing fossil fuels by petroleum industry. A novel approach recently proposed is the microwave/electromagnetic-assisted catalytic heating technology for in-situ hydrogen generation and extraction directly from petroleum reservoirs. Here we further evaluate the potential of shale oil for H2 generation in the presence of shale rocks under microwave irradiation. A series of lab-scale experiments are conducted for shale oil conversion to hydrogen in Mancos shale rock samples without artificial catalysts. The real-time variations of measured temperature of rock samples, gas flow rate, and concentration of hydrogen and other generated gases are monitored. We find that the pure shale rocks can be heated up to over 600 °C without any promoter at an input power of 1.5 kW during microwave heating. A sudden increase of measured temperature of the Mancos shale is monitored at a temperature below 300 °C during microwave irradiation, referred to as "temperature soaring" (TS) phenomenon. Once TS phenomenon happens, the shale rock can be easily heated at a much lower microwave power. Furthermore, minerals in shale rocks have a significant natural catalytic effect on shale oil conversion to H2. A concentration of 1% hydrogen starts to be monitored in generated gases from shale oil at a measured temperature of 253-421 °C in the presence of Mancos rocks, much lower than the sample with 100% quartz at 523 °C. The highest H2 production rate and H2 concentration are 178 sccm and 77 mol.% from the conversion of 0.4 g shale oil, respectively. Additionally, long-range well-ordered carbon is commonly found in the shale rocks after microwave heating experiments.
Challenges for Repurposing Oil and Gas Wells for Geothermal Applications
Authors: Santos L. , Taleghani A. Dahi 
Published: August 2023

Abstract
This work provides insights into the technical and economic viability of repurposing oil and gas wells for geothermal energy production for direct heating. The potential benefits, especially for areas that are highly dependent on fossil fuels for heating, and challenges of this approach are assessed while technical, market, and policy barriers for future developments are identified. Repurposing oil and gas wells to geothermal energy requires a multidisciplinary approach that involves expertise in geology, engineering, and regulatory affairs. A thorough analysis of data on the physical, technical, economic, and environmental aspects of repurposing oil and gas wells for geothermal energy is conducted, including well logs, geologic maps, temperature and flow rate measurements, cost estimates, and environmental impact assessments. In addition, a numerical simulation is run to evaluate efficiency and power output from open-loop and closed-loop geothermal systems. The data analysis combined with numerical simulation will help determine the feasibility and potential benefits of this approach. Compared to geothermal reservoirs, the low temperature of oil and gas reservoirs often limits their potential for power generation development. However, the results demonstrate that with careful consideration of site selection, engineering, and environmental factors, repurposing oil and gas wells for geothermal community heating can be a cost-effective way to utilize existing infrastructure for renewable energy development. Even considering workover costs to ensure wellbore integrity, the approach is less costly than drilling and completing new wells. Other measures to improve efficiency include the use of high thermal conductivity materials and proper reservoir management to ensure heat is being extracted sustainably. While open-loop geothermal system resulted in higher temperatures, closed-loop avoids uncertainties in the rock properties and can be easily implemented. Factors such as the depth and location of the well, the geology of the surrounding area, and the available technology and infrastructure all play a role in determining the actual heat output from a repurposed geothermal well from oil and gas. Repurposing oil and gas wells to geothermal energy for community heating represents an innovative and sustainable approach to energy generation that makes use of existing resources and infrastructure in a new and beneficial way.
RETRACTED: Effect of Morphologic Changes in the Posterior Glenoid Rim on Rotator Cuff Impingement in Baseball Players
Authors: Takahashi Makoto , Mutsuzaki Hirotaka , Iwamoto Koji , Monma Masahiko , Mizukami Masafumi 
Published: August 2023

Abstract

The authors have requested that this preprint be removed from Research Square.
A novel scaffold of icariin/porous magnesium alloy repaired knee cartilage defect in rat by Wnt/β-catenin signaling pathway
Authors: Zhang Mengwei , Jia Gaozhi , Weng Jian , Zhu Yuanchao , Lin Jianjin , Yang Qi , Fang Chongzhou , Zeng Hui , Yuan Guangyin , Yang Jun , Yu Fei 
Published: August 2023

Abstract
Cartilage defects caused by joint diseases are difficult to treat clinically. Tissue engineering materials provide a new means to promote the repair of cartilage defects. The purpose of this study is to design a novel scaffold of porous magnesium alloy loaded with icariin and sustained release, in order to explore the effect and possible mechanism of this scaffold in repairing SD rat knee articular cartilage defect. We constructed a novel type of icariin/porous magnesium alloy scaffold, observed the structure of the scaffold by electron microscope, detected the drug release of icariin in the scaffold and the biological safety, and established an animal model of cartilage defect in the femoral intercondylar fossa of the knee joint in rats, the scaffold was placed in the defect. After 12 weeks of repair, the rat knee articular cartilage repair was evaluated by gross specimens and micro-CT,and HE, Safranin O-fast green, and toluidine blue staining combined with modified Mankin's score. The protein expressions of Wnt/β-catenin signaling pathway-related factors (β-catenin, Wnt5a, Wnt1, sFRP1) and chondrogenic differentiation-related factors (Sox9, Aggrecan, Col2α1) were detected by immunohistochemical staining. We found that the novel scaffold of icariin/porous magnesium alloy can release icariin slowly and has biosafety in rats. Compared with other groups, icariin/porous magnesium alloy can significantly promote the repair of cartilage defects and the expressions of β-catenin, Wnt5a, Wnt1, Sox9, Aggrecan, and Col2α1 (P<0.05). This novel scaffold can promote the repair of rat knee cartilage defects, and this process may be achieved by activating the Wnt/β-catenin signaling pathway.
Fabrication and testing of crop waste Ceiba Pentandra Shell Powder reinforced biodegradable composite films
Authors: M Kaliraj , P Narayanasamy , B Balavairavan , P Balasundar 
Published: August 2023

Abstract
Ceiba Pentandra Shell Powder (CPSP) bio waste is chosen as a bio filler combined with Polyvinyl Alcohol (PVA) as a matrix to make biofilms to increase the exploitation of bio waste materials and reduce the use of plastic materials. The fabricated biofilms endured the structural, thermal, microstructural, mechanical, UV barrier, opacity, water absorption, and soil burial properties. FTIR plots indicated no significant chemical reaction or formation of new functional groups during an interaction between PVA and CPSP. XRD diffractograms represented the crystallinity index (35.3, 38.6, 42.3, 46.4 and 48.5%) and crystalline size (18.14, 20.89, 23.23, 24.87and 26.34 nm) of biofilms increased with CPSP loading (5–25 wt. %). The PVA/CPSP films are thermally stable up to 322 ℃. The peak highs of AFM images showed that the films surface roughness gradually increased from 94.75 nm (5 wt. % CPSP) to 320.17 nm (25 wt. % CPSP). The FESEM micrographs clarify the homogenous distribution of CPSP materials in the PVA matrix. Tensile strength and tensile modulus are noticeably increased by 26.32% and 37.92%, respectively, due to the loading of CPSP from 5 wt. % to 20 wt. % in the PVA matrix. The PVA/CPSP films outperform than pure PVA films in UV shielding (350–450 nm). The 59% of weight loss of films was estimated during 60 days of burial time. Overall, PVA/ CPSP (5–25 wt. %) films are biodegradable and have promising applications as good packaging material.
iTRAQ-based proteomic study discovered LAMP2 related to HIV-1 latency
Authors: Yin Lin , Wang Qimin , Liu Siyuan , Chen Jun , Zhang Yujiao , Lu Lingqing , Lu Hongzhou , Song Zhigang , Zhang Lijun 
Published: August 2023

AbstractTo identify potential biomarkers related to HIV latency on the cell surface, a subcellular proteomic study was performed using an HIV-1 latency cell line (U1 (HIV-1-integrated U937 cell line)) and a control (U937). Differentially expressed proteins were analyzed using bioinformatics, followed by western blotting and multiple reaction monitoring of cell lines and/or resting CD4 + T cells from patients. The relationship between a differentially expressed protein (lysosome-associated membrane glycoprotein 2) and HIV-1 reactivation (by panobinostat) or a lysosomotropic agent (hydroxychloroquine) was studied. Totally, 110 differentially expressed proteins were identified in U1 cells compared with U937 cells. Bioinformatics analysis suggested that the immune response and phagosomes were associated with the altered proteins. LAMP2, leukocyte surface antigen CD47, CD55 and ITGA6 were downregulated in HIV-1 latent cells. LAMP2 was downregulated in enriched resting CD4 + T cells from patients infected with HIV. LAMP2 can be upregulated after HIV-1 reactivation and hydroxychloroquine stimulation. Our results indicated that the endosomal/lysosomal pathway was involved in HIV latency in macrophage cell lines. LAMP2 down-modulation was associated with HIV latency, and the re-expression of LAMP2 accompanied the viral latency/productive infection transition. This study offers new clues for understanding the mechanism of HIV-1 latency and the eradication of HIV reservoirs.
Assessment of the Optimal Generation Period and Size of Human iPSC-Derived Cardiac Organoids for Cardiotoxicity Drug Testing
Authors: Lee Sang Woo , Song MyeongJin , Woo Dong-Hun , Jeong Gi Seok 
Published: August 2023

Abstract
Background
Human-induced pluripotent stem cell-derived cardiac organoids (hiPSC-COs) have emerged as valuable tools for cardiotoxicity drug screening, given their ability to recapitulate in vivo cardiac tissue functions and facilitate rapid assessment of drug stability to prevent toxicity. However, the lack of established criteria for the differentiation period and size during the generation of functional hiPSC-COs can introduce low accuracy in drug screening responses results. Hence, it is crucial to establish appropriate criteria for the generation period and size of hiPSC-COs to ensure reliable cardiotoxicity drug screening.
Methods
In this study, we generated different-sized hiPSC-COs in two types of microwell arrays through a one-stop generation method. The two-sized hiPSC-COs were continuously monitored until a stable cardiac beating rate was confirmed during the differentiation period. We evaluated and compared the functionality such as calcium transients at the selected differentiation day that showed a stable beating rate with a specific focus on determining the minimal differentiation period required for generating functional hiPSC-COs. A physiological test was conducted to verify the reactivity to the drug in hiPSC-COs according to the differentiation period and size. Subsequently, we conducted a cardiotoxicity drug screening test using compounds known to induce in vivo heart failure. Finally, characterization was analyzed by immunostaining assay to compare and confirm the phenotype of the two-sized hiPSC-COs at the selected differentiation period.
Results
During the differentiation period to generate hiPSC-COs, we identified the time point at which the smaller organoids among the two sizes of hiPSC-COs began to show a stable beating rate, which was an optimal period to lead to meaningful response results to cardiotoxicity drugs. Moreover, large organoids confirmed that cardiac properties disappeared as the differentiation period progressed, suggesting insight into the size limitation on the generation of hiPSC-COs for cardiotoxicity testing. Furthermore, an additional analysis method was proposed for subtle reactions that are difficult to confirm solely using the beating rate analysis in drug response testing.
Conclusion
We expect that these findings may contribute to the field of drug development by ensuring significant drug response results and enhancing the reliability of cardiotoxicity testing using hiPSC-COs.
The Impact of the COVID-19 Lockdown on Lifestyles and Serum Indicators in the Working Population
Authors: Lin Binwu , Huang Weilan 
Published: August 2023

Abstract
Background
The coronavirus disease 2019 (COVID-19) outbreak that started in China in late December 2019 compelled China to enact sanitary regulations and social segregation policies. Approximately 1.4 billion Chinese people experienced lockdowns, had to work remotely and homeschool their children, and had difficulties adjusting to stressful events and quarantine. Due to the lack of information on the effects of lockdown on health status, this study examined how changes in dietary practices, physical activity, and serum markers were affected by COVID-19 lockdowns in the working population.
Methods
An observational retrospective study was conducted, and office workers who underwent two routine physical examinations prior to and following the initial lockdown were included. The sample was classified into four categories based on sex and body mass index (BMI). Medical examination reports provided data on height, weight, and serum biochemical indices. The health risk assessment questionnaire collected demographic and lifestyle information, including physical activity, smoking and drinking.
Results
A total of 533 respondents aged 22 to 60 participated in this study. After the lockdown, BMI increased in all normal BMI groups (all p < 0.0001). Increases in serum aspartate aminotransferase (AST), serum alanine transaminase (ALT), gamma-glutamyl transferase (GGT), total cholesterol, low-density lipoprotein (LDL) and serum glucose levels were found in the normal BMI groups (all p < 0.05). We also detected a significant drop in serum uric acid (UA) levels in all BMI groups (all p < 0.05). PA decreased significantly during lockdown in the normal BMI subgroups (z=-4.453, p < 0.001) but remained the same in the high BMI subgroups (z=-1.07, p = 0.285). The results showed that smoking and drinking decreased during quarantine (smoking, z=-4.796, p < 0.00001 in normal BMI groups, z=-2.163, p < 0.00001 in high BMI groups; drinking, z=-5.667, p < 0.00001 in normal BMI groups, z=-2.668, p < 0.00001 in high BMI groups).
Conclusion
This study showed that lockdowns had a significant impact on office workers’ lifestyles and serum markers, especially in normal BMI groups. Additional research is needed to comprehend how individual workers’ health-related behaviors—such as nutrition and other serum markers—changed over time during lockdown.