bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influence of extent and age at corpus callosotomy on seizure outcomes. A single center experience
Authors: Chourasia Nitish , Stone Scellig S. D. , Tsuboyama Melissa , Madsen Joseph R. , Ryan Morgan , Zhang Bo , Libenson Mark H. , Bolton Jeffrey , Harini Chellamani 
Published: August 2023

AbstractCorpus callosotomy (CC) is a palliative treatment for drop seizures in patients with drug‐resistant nonlocalizable epilepsy. We compared drop seizure outcomes between patients undergoing anterior CC versus complete CC and examined factors impacting outcomes for drop seizures including age at CC and duration of epilepsy. A retrospective review of patients who underwent CC between 2003 and 2022 with a minimum of 6 months postsurgical follow‐up was included. Outcome measure for drop seizures included seizure reduction ≥50% from baseline as well as elimination of drop seizures. Thirty‐eight patients were included. Overall, ≥50% reduction in drop seizures occurred in nearly 70% (23 out of 33) patients with complete elimination in 58% (19 out of 33). Compared with anterior CC (n = 13), patients undergoing complete CC (n = 25) had increased likelihood of ≥50% reduction (p = 0.006) or elimination (p = 0.024) of drop seizures. Regression analysis showed that complete CC was the primary predictor for improved drop seizure outcomes (elimination, p = 0.014 or ≥50% reduction, p = 0.006), while age at CC and duration of epilepsy did not impact the outcomes. Compared to anterior CC, complete CC was significantly more likely to lead to improvement/freedom from drop seizures. Age at CC or duration of epilepsy did not influence drop seizure outcomes.
Therapeutic drug monitoring in adolescents with anorexia nervosa for safe treatment with adjunct olanzapine
Authors: Karwautz Andreas , Zeiler Michael , Schwarzenberg Julia , Mairhofer Dunja , Mitterer Michaela , Truttmann Stefanie , Philipp Julia , Koubek Doris , Glüder Maria , Wagner Gudrun , Malcher Anouk , Schöfbeck Gabriele , Laczkovics Clarissa , Rock Hans W. , Zanko Annika , Imgart Hartmut , Banaschewski Tobias , Fleischhaker Christian , Correll Christoph U. , Wewetzer Christoph , Walitza Susanne , Taurines Regina , Fekete Stefanie , Romanos Marcel , Egberts Karin , Gerlach Manfred 
Published: August 2023

AbstractObjectiveMedication is commonly used in anorexia nervosa (AN) despite largely missing high grade evidence. Olanzapine (OLZ) is the best‐evidenced substance used off‐label in this group, with conflicting outcome regarding BMI, clinical and safety parameters. Therefore, it is important to strictly assure quality of treatment with OLZ in AN by using ‘Therapeutic Drug Monitoring’ according to AGNP‐guidelines, including serum levels and adverse drug reactions (ADRs) to support safety for adolescents with AN and attempt to generate an initial age‐ and disorder‐specific therapeutic reference range.MethodSixty‐five adolescents with AN (aged 10–18) treated with OLZ (98% female; 97.5% AN‐restricting‐type) were prospectively observed, ADRs reported, and correlations between dosage and serum levels measured at trough level were calculated, a preliminary therapeutic range defined.ResultsMean dosage of OLZ was 8.15 (SD: 2.91) mg and 0.19 (SD: 0.07) mg/kg respectively, average concentration was 26.57 (SD: 13.46) ng/mL. Correlation between daily dosage/dosage per kg and serum level was 0.72 (**p < 0.001)/0.65 (**p < 0.001), respectively. ADRs with impairment were rare (6.3%). 75% improved clinically (CGI). BMI increased significantly by 1.5 kg/m2 (t = 10.6, p < 0.001). A preliminary therapeutic reference range is 11.9 and 39.9 ng/mL.ConclusionsOLZ in the hands of specialists is a well‐tolerated and safe treatment adjunct for adolescents with AN.
The formation and evolution of Al‐rich protoliths in the southern Ribeira belt, Brazil: Insights from remnants of a Precambrian paleoweathering surface
Authors: Santos Larissa da Rocha , Fedalto Guilherme , Bahniuk Anelize Manuela , Casapula Inaiara , Oliveira Franciele , Cury Leonardo Fadel 
Published: August 2023

AbstractBauxitic clays, clayey bauxites and bauxites are residual products formed from the weathering of aluminosilicate‐rich parent rocks under wet and warm conditions. These deposits show a complex interplay between remobilisation of pre‐existing kaolinitic soils and depositional micro‐environments.In the southern Ribeira belt, Brazil, a paleoweathering surface developed on the continental shelf of the Capiru Group passive margin strata and on its basement/source rocks. This weathering cycle gave rise to a paleosol profile on the continental domain and a karstic paleotopography on the emerged carbonate shelf. The surface and karstic nets were later caped and filled with Al‐rich materials, typical of remobilised soils, bauxitic clays, clayey bauxites and pods of karst‐type bauxites.The age of the disconformity is Pre‐Brazilian/Pan‐African, implying a Neoproterozoic age for the weathering surface. In this study, we investigate the relationship among disconformities, paleosols and karst topography to better understand the stratigraphic control, chemical composition and mineralogy of the Al‐rich materials. We interpret this horizon as the remnants of a (meta‐)paleoweathering surface that can serve as a valuable key bed for stratigraphic correlation and paleogeographic reconstructions.We propose that the triggering process for the genesis of the paleosol profiles, bauxitic material and bauxite pods was a coupled mechanism between favourable climate and uplift along the northern margin of the Curitiba–Angola craton, creating a karstic topography that allowed the down‐plain transport of Al‐rich materials. In a later stage, these deposits were metamorphosed, developing a series of Al silicates in unusual paragenesis, typical of Al‐rich protoliths.The presence of these paragenesis, along with the recognition of the disconformity–paleoweathering surface pair, could be a useful tool to understand the paleoenvironmental and paleogeographic evolution of highly deformed terrains.
Patterns of vegetation expansion during dune stabilization at the decadal scale
Authors: Gao Jinjuan , Kennedy David M. , McSweeney Sarah 
Published: August 2023

AbstractThere is a global stabilization of coastal dunes, during which, the trajectory of vegetation expansion was rarely studied and, thus, still remains unclear. In this study, patterns and driving factors of vegetation expansion during dune stabilization were examined in three coastal dunefields in Victoria, Australia. Results show that the trajectory of vegetation expansion is fundamentally determined by dunefield topography. At the dunefield scale, vegetation colonization can take place at different parts in dunefield, including (1) the landward margins, where the ecosystem is frequently dominated by woody species and the soil is more mature with higher nutrients and water content; (2) the interdune depressions, where is usually dominated by lower elevations and shelters; and (3) the seaward deflation basins and plains, where vegetation shows a more discontinuous and patchy distribution. At the individual dune scale, vegetation usually expands vertically from the dune toe towards the upper dune slope at both the lee side and stoss face of dunes/dune ridges. The deflation basins are more likely to be free of vegetation establishment. Pre‐existing vegetation also plays a critical role in dune re‐vegetation, and subsequent vegetation expansion takes place around the vegetation patches, more usually towards the downwind direction, probably because it can provide seeds for subsequent vegetation spread. Once established, it can also change the micro‐climates by providing shelter, increasing the surface roughness and changing the wind regimes. More importantly, existing vegetation can form a ‘fertility island’ with higher nutrients, organic matter and water‐holding capacity. Conceptual models depicting the trajectory of vegetation expansion were also generalized. This research provides an original perspective and innovative insight into the patterns and driving factors of vegetation expansion during dune stabilization, under the background of global coastal ‘greening’, which could be helpful to identify opportunities for management interventions.
Plaque vicinity as a hotspot of microglial turnover in a mouse model of Alzheimer's disease
Authors: Olmedillas Maria , Brawek Bianca , Li Kaizhen , Richter Cris , Garaschuk Olga 
Published: August 2023

AbstractMicroglia, the major immune cells of the brain, are functionally heterogeneous but in vivo functional properties of these cells are rarely studied at single‐cell resolution. By using microRNA‐9 regulated viral vectors for multicolor labeling and longitudinal in vivo monitoring of individual microglia, we followed their fate in the cortex of healthy adult mice and at the onset of amyloidosis in a mouse model of Alzheimer's disease. In wild‐type mice, microglia were rather mobile (16% of the cells migrated at least once in 10–20 days) but had a low turnover as documented by low division and death rates. Half of the migratory events were tightly associated with blood vessels. Surprisingly, basic migration properties of microglia (i.e., fraction of migrating cells, saltatory migration pattern, speed of migration, translocation distance, and strong association with blood vessels) were preserved in amyloid‐depositing brains, despite amyloid plaques becoming the major destination of migration. Besides, amyloid deposition significantly increased microglial division and death rates. Moreover, the plaque vicinity became a hotspot of microglial turnover, harboring 33% of all migration, 70% of death and 54% of division events.
A new one‐stop interdisciplinary cognitive clinic model tackles rural health inequality and halves the time to diagnosis: Benchmarked against a national dementia registry
Authors: Alty Jane , Lawler Katherine , Salmon Katharine , McDonald Scott , Stuart Kimberley , Cleary Alison , Ma Jak , Rudd Kaylee , Wang Xinyi , Chiranakorn‐Costa Sigourney , Collins Jessica , Merl Helga , Lin Xiaoping , Vickers James C. 
Published: August 2023

AbstractObjectivesUnequal access to cognitive assessments is a major barrier to timely diagnosis, especially for those living in rural or remote areas. ‘One‐stop’ cognitive clinic models are a proposed solution, but few such clinics exist. We evaluate the implementation of a new one‐stop State‐wide clinic model in Tasmania, Australia, where 27% of people live in rural/remote areas.MethodsA novel single‐visit protocol has been developed, comprising interdisciplinary medical and cognitive assessments, research participation, consensus diagnosis and management plan. A cross‐sectional evaluation was undertaken using the RE‐AIM (reach, effectiveness, adoption, implementation, maintenance) framework and results benchmarked against the national Australian Dementia Network Registry.ResultsOver the first 52 consecutive weekly clinics: Reach: 130 adults were assessed (mean age [SD] 70.12 years [10.31]; 59.2% female) with 40 (36.8%) from rural/remote areas. Effectiveness: 98.5% (128/130) received a same‐day diagnosis: 30.1% (n = 40) Subjective Cognitive Decline, 35.4% (46) Mild Cognitive Impairment, 33.1% (43) dementia and one case inconclusive. Adoption: 22.9% (156) of General Practitioners referred patients. Implementation: Nearly all ‘ideal’ diagnostic clinical practices were met and >90% of surveyed patients reported ‘good/very good’ clinic experience. The wait from referral to diagnosis was 2 months shorter than other national Registry clinics (78 vs. 133 days).ConclusionsThis ‘one‐stop’ model provides an interdisciplinary consensus cognitive diagnosis quickly and is well accepted; this may reduce health inequities especially for people living in rural/remote areas. This cognitive clinic model may be of relevance to other centres worldwide and also provides a rich data source for research studies.
Single‐unit unrelated cord blood transplantation versus HLA‐matched sibling transplantation in adults with advanced myelodysplastic syndrome: A registry‐based study from the adult MDS working group of the Japanese society for transplantation and cellular therapy
Authors: Konuma Takaaki , Itonaga Hidehiro , Shimomura Yoshimitsu , Fujioka Machiko , Aoki Kazunari , Uchida Naoyuki , Onizuka Makoto , Jinguji Atsushi , Tanaka Masatsugu , Ueda Yasunori , Katayama Yuta , Sawa Masashi , Tanaka Haruyuki , Nakamae Hirohisa , Kawakita Toshiro , Maruyama Yumiko , Takahashi Satoshi , Ishimaru Fumihiko , Kanda Junya , Ichinohe Tatsuo , Atsuta Yoshiko 
Published: August 2023

AbstractAllogeneic hematopoietic stem cell transplantation (HCT) remains the only potential curative therapeutic modality for advanced myelodysplastic syndrome (MDS). Within HCT, the advancement of cord blood transplantation (CBT) procedures has resulted in a drastic expansion of CBT as a donor source for MDS. However, data comparing matched sibling donors (MSDs) HCT with CBT for advanced MDS, which was defined as refractory anemia with an excess of blasts (RAEB)‐1 and RAEB‐2 according to the World Health Organization classification at the time of HCT, have not been explored. We retrospectively compared survival and other posttransplant outcomes in 999 adult patients with advanced MDS after receiving allogeneic HCT in Japan between 2011 and 2020, using either MSD (n = 331) or single‐unit unrelated cord blood (UCB) (n = 668). In the multivariate analysis, there were no significant differences in overall survival (hazard ratio [HR], 1.10; 95% confidence interval [CI], 0.90–1.34; P = 0.347), disease‐free survival (HR, 1.01; 95% CI, 0.84–1.23; P = 0.845), relapse (HR, 0.88; 95% CI, 0.68–1.15; P = 0.370), or non‐relapse mortality (HR, 1.15; 95% CI, 0.87–1.50; P = 0.310) between MSD recipients and UCB recipients. UCB was significantly associated with lower neutrophil (HR, 0.28; 95% CI, 0.24–0.33; P < 0.001) and lower platelet (HR, 0.29; 95% CI, 0.23–0.36; P < 0.001) recovery compared to MSD. UCB was significantly associated with a lower incidence of chronic graft‐versus‐host disease (GVHD) (HR, 0.57; 95% CI, 0.44–0.75; P < 0.001) and extensive chronic GVHD (HR, 0.46; 95% CI, 0.32–0.67; P < 0.001) compared to MSD. Similar results were observed after adjusting for differences between MSD and UCB recipients by propensity score matching analysis. Our study demonstrated that single CBT and MSD HCT had similar survival outcomes for adult patients with advanced MDS despite the lower hematopoietic recovery in CBT recipients and higher chronic GVHD in MSD recipients.
Stakeholders' expectations of precision medicine: A qualitative study to identify areas of (mis)alignment
Authors: Knott Tanya , Creeden James , Horbach Benjamin , Rauch‐Zumbrägel Maximiliane , Vat Lidewij , Harnik Helena , Maravic Zorana 
Published: August 2023

AbstractBackground and AimsTo sustainably address challenges in implementing precision medicine (PM), coordinated efforts of different stakeholders are required. Understanding their expectations represents a first key step toward aligning on future actions and strategies. Here, we aimed to explore the expectations of different stakeholders from themselves and each other regarding PM.MethodsThis collaborative qualitative study was initiated by the global multistakeholder consortium From Testing to Targeted Treatments (FT3). Structured interviews were conducted with participants from five stakeholder groups: patients/patient advocates, healthcare providers (HCPs), researchers, policymakers/regulators/payers and industry representatives. A broad reach across geography, roles, experiences, and disease areas was sought. Results were analyzed by grounded theory methodology.ResultsAll stakeholders stated that optimal implementation of PM can only be achieved through collaboration; industry representatives were the biggest promoters of collaboration. Stakeholders agreed that PM should be implemented focusing on the patient's best interest; HCPs were seen as important gatekeepers for PM by interacting directly with patients, and policymakers/payers were perceived as the most important drivers of access to PM. Areas of misalignment included the role of industry in clinical trial design and in access to PM (perceived as important by patients, HCPs and policymakers but not by industry representatives), and the stakeholders responsible for elaborating guidelines on PM use (patients indicated policymakers, while researchers indicated themselves). Priorities for optimal PM implementation and suggested actions included the need for enhancing high‐level policy focus, improving genomic literacy, optimizing the health technology assessment for PM, advocating for equitable access, promoting collaboration between industry and other stakeholder groups and development of reliable research standards.ConclusionStakeholder expectations revealed in this study suggested that no stakeholder group can drive change on its own; a global, multistakeholder collaborative approach that brings together current programs and best practices to support universal access to PM is needed.
Prevalence of body dysmorphic disorder in rhinoplasty candidates: A systematic review and meta‐analysis
Authors: Nabavizadeh Sara S. , Naseri Reyhaneh , Sadeghi Erfan , Afshari Aylar , Dehdari Ebrahimi Niloofar , Sadeghi Alireza 
Published: August 2023

AbstractBackgroundBody dysmorphic disorder (BDD) is a prevalent mental disorder, particularly in those seeking plastic surgery, leading to unnecessary surgeries and postsurgical dissatisfaction. Among the plastic surgeries, rhinoplasty is the most commonly sought, yet the data on prevalence of BDD among the candidates of rhinoplasty is limited. Therefore, this systematic review and meta‐analysis aimed to estimate the prevalence of BDD in rhinoplasty candidates.MethodsThe online libraries of Web of Science, PubMed, Cochrane Library, ProQuest, Research Square, Scopus, and Google Scholar were searched up to August 2022. Statistical analyses were performed using STATA software (v. 16). The heterogeneity was determined using the I2 statistic, and an overall estimated analysis was conducted. Subgroup analyses were performed on study year, age, gender, World Health Organization regional classification, sociodemographic index, country, sample size, and employed diagnostic tool. A meta‐regression analysis was performed to identify potential sources of heterogeneity.ResultsOut of 12,999 studies assessed, 18, with a combined sample size of 2132 individuals, met our criteria and were included in the study. The pooled prevalence of BDD was 32.7% (95% CI: 23.6−41.7; I2 = 96.45%). Subgroup analyses revealed the studies that were conducted in the European region (42.8%), with a sample size of ≥100 (40.2%), utilized the BDD modification of the Y‐BOCS (BDD‐YBOCS) diagnostic method (47.3%), and with a quality score of ≥6 (34.2%) demonstrated higher prevalence of BDD. The meta‐regression analysis identified a higher prevalence in the BDD‐YBOCS diagnostic method than in the BDD questionnaire (β: 0.23; 95% CI: 0.04−0.43; p = 0.022).ConclusionsThe prevalence of BDD is high in those seeking rhinoplasty. Clinicians should be aware of BDD symptoms to prevent unnecessary surgery and dissatisfaction. Public awareness through the media and access to affordable medical services should also be provided.
Examining the relationship between depression and medication adherence among elderlies suffering from cardiovascular disease referring to the clinics affiliated with Kermanshah University of Medical Sciences: A cross‐sectional study
Authors: Brimavandi Mina , Abbasi Parvin , Khaledi‐Paveh Behnam , Salari Nader 
Published: August 2023

AbstractBackgroundIn recent years, around 30% of all mortalities worldwide has been related to cardiovascular disease (CVD). The most important predictor solution of cardiovascular events is enhancing medication adherence. Meanwhile, the main reason behind development of physical disorders among the elderly is depression. In this regard, the present research was performed to determine the relationship between depression and medication adherence among the elderly suffering from CVD.MethodsA cross‐sectional study was done via an analytical approach on 188 elderlies fulfilling the inclusion criteria. The participants were chosen through convenience nonrandomized sampling from March to July 2022. The data were collected through demographic and healthcare information form plus Madanloo chronic disease medication adherence and geriatric depression scale. The analysis of the data was done by SPSS 26 plus Stata 14.2.ResultsThe mean depression score was 5.6(4.3) and the mean score of medication adherence in the elderlies was 168.03(23.85). The prevalence of depression was higher in women than in men (p = 0.015), and the elderlies differing from heart failure reported the minimum extent of medication adherence. The findings obtained from analysis of variance showed that age, level of education, and monthly level of income were among the effective demographic factors in the extent of depression and medication adherence (p < 0.05). Meanwhile, 26% of changes in medication adherence can be attributed to depression. Further, the results of the multiple linear regression model reported that depression, age, and polypharmacy are among the predictors of medication adherence.Discussion and ConclusionA weak to moderate relationship existed between depression and medication adherence among these elderlies. Given the growing elderly population, the importance of depression, and lack of medication adherence in incidence of CVD events, it is recommended to train the healthcare team to monitor the elderly regarding depression symptoms.
CCA repair or ECA ligation—Which middle cerebral artery occlusion is better in the reperfusion mouse model?
Authors: Hu Yue , Yang Zhen‐Hong , Yan Feng , Huang Shuang‐Feng , Wang Rong‐Liang , Han Zi‐Ping , Fan Jun‐Fen , Zheng Yang‐Min , Liu Ping , Luo Yu‐Min , Li Si‐Jie 
Published: August 2023

AbstractA reliable animal model is essential for ischemic stroke research. The implications of the external carotid artery (ECA) transection or common carotid artery (CCA) ligation have been described. Thus, a modified animal model, the CCA‐repair model, has been established, and studies have shown that the CCA‐repair model has potential advantages over the CCA‐ligation model. However, whether the CCA‐repair model is superior to the ECA‐ligation model remains unclear. Sixty male C57BL/6 mice were randomly assigned to establish the CCA‐repair (n = 34) or ECA‐ligation (n = 26) models. Cerebral blood flow before middle cerebral artery occlusion (MCAO), immediately after MCAO and reperfusion were monitored and the operation duration, postoperative body weight, and food intake within 7 days, and the number of intraoperative and postoperative deaths within 7 days were recorded in the two models. Modified neurological severity scores and Bederson (0–5) scores were used to evaluate postoperative neurological function deficits on Days 1/3/5/7. 2,3,5‐Triphenyltetrazolium chloride staining was used to quantify lesion volume on Day 7 after the operation. We found the establishment of the CCA‐repair model required a longer total operation duration (p = 0.0175), especially the operation duration of reperfusion (p < 0.0001). However, there was no significant difference in body weight and food intake development, lesion volume and intragroup variability, neurological function deficits, mortality, and survival probability between the two groups. The CCA‐repair model has no significant advantage over the ECA‐ligation model. The ECA‐ligation model is still a better choice for focal cerebral ischemia.