bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prescribed performance LOS guidance-based dynamic surface path following control of surface vessel with position and heading errors constraint
Authors: Shen Zhipeng , Li Ang , Li Li , Yu Haomiao 
Published: April 2023

AbstractConcentrating on a surface vessel with input saturation, model uncertainties and unknown disturbances, a path following the adaptive backstepping control method based on prescribed performance line-of-sight (PPLOS) guidance is proposed. First, a prescribed performance asymmetric modified barrier Lyapunov function (PPAMBLF) is used to design the PPLOS and the heading controller, which make the path following position and heading errors meet the prescribed performance requirements. Furthermore, the backstepping and dynamic surface technique (DSC) are used to design the path following controller and the adaptive assistant systems are constructed to compensate the influence of input saturation. In addition, neural networks are introduced to approximate model uncertainties, and the adaptive laws are designed to estimate the bounds of the neural network approximation errors and unknown disturbances. According to the Lyapunov stability theory, all signals are semi-globally uniformly ultimately bounded. Finally, a 76$\,{\cdot }\,$2 m supply surface vessel is used for simulation experiments. The experimental results show that although the control inputs are limited, the control system can still converge quickly, and both position and heading errors can be limited to the prescribed performance requirements.
Emotion regulation as a predictor of patterns of change in behavior problems in previously institutionalized youth
Authors: Perry Nicole B. , Donzella Bonny 
Published: April 2023

AbstractLongitudinal trajectories of psychopathology in previously institutionalized (PI) youth were identified and biobehavioral emotion regulation processes were examined as developmental mechanisms that predict these trajectories. Mental health data were collected from PI (N = 132) and nonadopted (NA; N = 175) youth across four time points (participant age ranged from 7- to 21-year-old). Using semiparametric group-based methods, the probability that each individual belonged to a distinct group that followed a specific pattern of behavior across time was estimated. We then tested whether unique aspects of emotion regulation (global, observed, and biological) were differentially associated with membership in externalizing and internalizing trajectory groups using multinomial logistic regression models. Four externalizing trajectories were identified for the PI and NA groups. For PI youth, global, observed, and biological emotion regulation processes were uniquely predictive of more adaptive externalizing trajectories. For NA youth, only parent-reported global emotion regulation was predictive of externalizing patterns. Three internalizing trajectories were identified for PI and NA youth. Generally, only parent-reported global emotion regulation predicted internalizing group membership for both PI and NA youth. Results suggest that biobehavioral emotion regulation processes may be particularly important predictors and potential points of intervention when targeting trajectories of externalizing behaviors in PI children.
Genetic confounding in bullying research: Causal claims revisited
Authors: Vrijen Charlotte , Nolte Ilja M. , Oldehinkel Albertine J. , Veenstra René , Kretschmer Tina 
Published: April 2023

AbstractBullying research has shown repeatedly that victims of bullying have an increased risk for later internalizing problems and bullies have an increased risk for later externalizing problems. Bullying involvement is often, either explicitly or implicitly, presented as part of a causal mechanism for maladjustment. However, genetic vulnerability may confound the reported associations. This study examined to what extent genetic vulnerability can account for the reported associations between bullying involvement (age 11-14) and later internalizing and externalizing problems (age 16), using data from the TRacking Adolescents' Individual Lives Survey (n = 1604). Because polygenic scores capture only a fraction of the total genetic effect, they were extrapolated to the size of single-nucleotide polymorphism and twin heritability estimates to examine genetic confounding while controlling for (hypothetical) polygenic scores that fully capture the genetic effect. Genetic vulnerability for internalizing and externalizing problems confounded, respectively, the association between bullying victimization and later internalizing problems, and the association between bullying perpetration and later externalizing problems. As such, this study showcases a method that can be broadly used to assess the magnitude of genetic confounding. Caution is, however, warranted in interpreting particularly the less straightforward extrapolations of polygenic scores to the size of twin heritability estimates.
Clinical benefits of vortioxetine 20 mg/day in patients with major depressive disorder
Authors: Christensen Michael C. , McIntyre Roger S. , Adair Michael , Florea Ioana , Loft Henrik , Fagiolini Andrea 
Published: April 2023

AbstractBackgroundVortioxetine has demonstrated dose-dependent efficacy in patients with major depressive disorder (MDD), with the greatest effect observed with vortioxetine 20 mg/day. This analysis further explored the clinical relevance of the more rapid and greater improvement in depressive symptoms observed with vortioxetine 20 mg/day vs 10 mg/day.MethodsAnalysis of pooled data from six short-term (8-week), randomized, placebo-controlled, fixed-dose studies of vortioxetine 20 mg/day in patients with MDD (N = 2620). Symptomatic response (≥50% decrease in Montgomery–Åsberg Depression Rating Scale [MADRS] total score), sustained symptomatic response, and remission (MADRS total score ≤10) were assessed by vortioxetine dosage (20 or 10 mg/day).ResultsAfter 8 weeks, 51.4% of patients receiving vortioxetine 20 mg/day had achieved symptomatic response vs 46.0% of those receiving vortioxetine 10 mg/day (P < .05). Significantly more patients achieved symptomatic response vs placebo from week 2 onwards for vortioxetine 20 mg/day and from week 6 onwards for vortioxetine 10 mg/day (both P ≤ .05). Sustained response was achieved from week 4 for 26.0% of patients receiving vortioxetine 20 mg/day vs 19.1% of those receiving vortioxetine 10 mg/day (P < .01), increasing to 36.0% and 29.8%, respectively, over the 8-week treatment period (P < .05). At week 8, 32.0% of patients receiving vortioxetine 20 mg/day were in remission vs 28.2% of those receiving vortioxetine 10 mg/day (P = .09). Rates of adverse events and treatment withdrawal were not increased during the week following vortioxetine dose up-titration to 20 mg/day.ConclusionVortioxetine 20 mg/day provides more rapid and more sustained symptomatic response than vortioxetine 10 mg/day in patients with MDD, without compromising tolerability.
Emergency department presentations with suicide and self-harm ideation: a missed opportunity for intervention?
Authors: Ross E. , Murphy S. , O’Hagan D. , Maguire A. , O’Reilly D. 
Published: April 2023

Abstract

Aims
Suicidal ideation constitutes a central element of most theories of suicide and is the defining facet separating suicide from other causes of death such as accidents. However, despite a high worldwide prevalence, most research has focused on suicidal behaviours, such as completed suicide and suicide attempts, while the greater proportion who experienced ideation, which frequently precedes suicidal behaviour, have received much less attention. This study aims to examine the characteristics of those presenting to EDs with suicidal ideation and quantify the associated risk of suicide and other causes of death.

Methods
Retrospective cohort study was performed based on population-wide health administration data linked to data from the Northern Ireland Registry of Self-Harm and centrally held mortality records from April 2012 to December 2019. Mortality data, coded as suicide, all-external causes and all-cause mortality were analysed using Cox proportional hazards. Additional cause-specific analyses included accidental deaths, deaths from natural causes and drug and alcohol-related causes.

Results
There were 1,662,118 individuals aged over 10 years, of whom 15,267 presented to the ED with ideation during the study period. Individuals with ideation had a 10-fold increased risk of death from suicide (hazard ratio [HRadj] = 10.84, 95% confidence interval [CI] 9.18, 12.80) and from all-external causes (HRadj = 10.65, 95% CI 9.66, 11.74) and a threefold risk of death from all-causes (HRadj = 3.01, 95% CI 2.84, 3.20). Further cause-specific analyses indicated that risk of accidental death (HRadj = 8.24, 95% CI 6.29, 10.81), drug-related (HRadj = 15.17, 95% CI 11.36, 20.26) and alcohol-related (HRadj = 10.57, 95% CI 9.07, 12.31) has also significantly increased. There were few socio-demographic and economic characteristics that would identify which of these patients are most at risk of suicide or other causes of death.

Conclusions
Identifying people with suicidal ideation is recognized to be both important but difficult in practice; this study shows that presentations to EDs with self-harm or suicide ideation represent an important potential intervention point for this hard-to-reach vulnerable population. However, and unlike individuals presenting with self-harm, clinical guidelines for the management and recommended best practice and care of these individuals are lacking. Whilst suicide prevention may be the primary focus of interventions aimed at those experiencing self-harm and suicide ideation, death from other preventable causes, especially substance misuse, should also be a cause of concern.
Colonial Schadenfreude: Mocking Europeans in the Philippines and the Dutch East Indies during the Russo-Japanese War (1904-1905)
Authors: Bayona Jorge 
Published: April 2023

AbstractThe Russo-Japanese War (1904-1905) attracted more than passing interest in the pages ofEl Renacimientoin the Philippines andBintang Hindiain the Dutch East Indies. Both publications featured pieces with editorializing tones that indulged in a significant degree of delight at the spectacle of Russian defeats and humiliations at the hands of the Japanese. This article engages in a close reading of this coverage to insert these instances of colonial schadenfreude into the broader trajectories of shaping communities of readers and nationalist awakenings in both colonies. Filipino nationalists inEl Renacimientodropped clear clues likening Russian aggression against Japan, an archipelagic Asian nation like the Philippines, to that which Filipinos experienced under the Americans, thus engaging in a symbolic displacement of that international event into their own historical present. Mocking Russians was part of a nationalist reading of the war that allowed for delight in the spectacle of White humiliation and the prospects of Japanese aid in anti-colonial struggle. The way the Russo-Japanese War was commented on byBintang Hindialess than ten years before the ‘national awakening’ period was remarkably similar to the reporting inEl Renacimiento. This isomorphism between two different historical contexts allows us to examine the role that mockery of Europeans played in forming a community of readers, nationalism, and the gradual undermining of the ideas of White supremacy on which colonialism was predicated.
Bursty Energetic Electron Precipitation by High‐Order Resonance With Very‐Oblique Whistler‐Mode Waves
Authors: Gan Longzhi , Artemyev Anton , Li Wen , Zhang Xiao‐Jia , Ma Qianli , Mourenas Didier , Angelopoulos Vassilis , Tsai Ethan , Wilkins Colin 
Published: April 2023

AbstractResonant interactions with whistler‐mode waves are one of the most important drivers for rapid energetic electron precipitation. In this letter, we study a conjunction event, where bursts of energetic electron precipitation (50–800 keV) with timescales of several seconds are observed by the twin ELFIN Cubesats at low Earth orbit, while very‐oblique intense whistler‐mode waves are observed by the Time History of Events and Macroscale Interactions during Substorms E satellite at the conjugate magnetic equator. Our observation‐constrained test‐particle simulations reveal that the electron precipitation, particularly above 100 keV, results from high‐order resonant scattering by the very‐oblique whistler‐mode waves. Our study provides the first direct evidence for high‐order resonance driven precipitation, explaining a bursty precipitation event. The results demonstrate that high‐order resonant scattering could be important, not only in long‐term diffusion models, but also in models of short timescale events.
Ocean Barotropic Vorticity Balances: Theory and Application to Numerical Models
Authors: Waldman Robin , Giordani Hervé 
Published: April 2023

AbstractThe barotropic vorticity (BV) balance is fundamental when interpreting the ocean gyre circulation. Here we propose an intercomparison of vorticity equations for the depth‐integrated flow applied to ocean models. We review four distinct variants of the BV balances, each giving access to diagnostic equations for the depth‐integrated ocean circulation, either meridional, across geostrophic contours or its divergence. We then formulate those balances in the Vorticity Balances in NEMO (VoBiN) diagnostic package aimed at the NEMO ocean platform and more generally C‐grid ocean models. We show that spatial discretization of the equations of motion have profound implications for those vorticity balances. Finally, we diagnose the main balances of a global ocean climate simulation. In all vorticity balances, topographic torques arise from interactions of the flow with slanting topography. We identify significant spurious topographic torques related to the model's C‐grid discretizations, and we suggest ways to address them. In the depth‐integrated and BV balances, bottom vortex stretching and bottom pressure torque drive the flow interaction with topography, respectively. Contrary to Sverdrup theory, the wind stress curl, although dominant in the interior Subtropics, becomes a minor player anywhere significant bottom velocities prevail. The geostrophic contour vorticity balance highlights the limits of barotropic models of the ocean circulation through the so‐called JEBAR term. Finally, the transport divergence vorticity balance stresses the limitations of Ekman plus geostrophic dynamics for the mass balance closure in ocean models. This framework should encourage ocean modellers to diagnose more routinely momentum and vorticity equations.
A Spatiotemporal Assessment of Extreme Cold in Northwestern North America Following the Unidentified 1809 CE Volcanic Eruption
Authors: Leland C. , D’Arrigo R. , Davi N. , Anchukaitis K. J. , Andreu‐Hayles L. , Porter T. J. , Galloway T. , Mant M. , Wiles G. , Wilson R. , Beaulieu S. , Oelkers R. , Gaglioti B. V. , Rao M. P. , Reid E. , Nixon T. 
Published: April 2023

AbstractTwo large volcanic eruptions contributed to extreme cold temperatures during the early 1800s, one of the coldest phases of the Little Ice Age. While impacts from the massive 1815 Tambora eruption in Indonesia are relatively well‐documented, much less is known regarding an unidentified volcanic event around 1809. Here, we describe the spatial extent, duration, and magnitude of cold conditions following this eruption in northwestern North America using a high‐resolution network of tree‐ring records that capture past warm‐season temperature variability. Extreme and persistent cold temperatures were centered around the Gulf of Alaska, the adjacent Wrangell‐St Elias Mountains, and the southern Yukon, while cold anomalies diminished with distance from this core region. This distinct spatial pattern of temperature anomalies suggests that a weak Aleutian Low and conditions similar to a negative phase of the Pacific Decadal Oscillation could have contributed to regional cold extremes after the 1809 eruption.
Extending Height Above Nearest Drainage to Model Multiple Fluvial Sources in Flood Inundation Mapping Applications for the U.S. National Water Model
Authors: Aristizabal Fernando , Salas Fernando , Petrochenkov Gregory , Grout Trevor , Avant Brian , Bates Bradford , Spies Ryan , Chadwick Nick , Wills Zachary , Judge Jasmeet 
Published: April 2023

AbstractHeight Above Nearest Drainage (HAND), a drainage normalizing terrain index, is a means able of producing flood inundation maps (FIMs) from the National Water Model (NWM) at large scales and high resolutions using reach‐averaged synthetic rating curves. We highlight here that HAND is limited to producing inundation only when sourced from its nearest flowpath, thus lacks the ability to source inundation from multiple fluvial sources. A version of HAND, known as Generalized Mainstems (GMS), is proposed that discretizes a target stream network into segments of unit Horton‐Strahler stream order known as level paths (LPs). The FIMs associated with each independent LP are then mosaiced together, effectively turning the stream network into discrete groups of homogeneous unit stream order by removing the influence of neighboring tributaries. Improvement in mapping skill is observed by significantly reducing false negatives at river junctions when the inundation extents are compared to FIMs from that of benchmarks. A more marginal reduction in the false alarm rate is also observed due to a shift introduced in the stage‐discharge relationship by increasing the size of the catchments. We observe that the improvement of this method applied at 4%–5% of the entire stream network to 100% of the network is about the same magnitude improvement as going from no drainage order reduction to 4%–5% of the network. This novel contribution is framed in a new open‐source implementation that utilizes the latest combination of hydro‐conditioning techniques to enforce drainage and counter limitations in the input data.
Exploring potential molecular resistance and clonal evolution in advanced HER2-positive gastric cancer under trastuzumab therapy
Authors: Xu Qi , Xu Xiaoqing , Tang Haimeng , Yan Junrong , Li Jingjing , Bao Hua , Wu Xue , Shao Yang , Luo Cong , Wen Haimin , Jin Jianying , Ying Jieer 
Published: April 2023

AbstractHER2-positive gastric cancer (GC) makes up 15–20% of all GC incidences, and targeted therapy with trastuzumab is the standard of treatment. However, the mechanisms of resistance to trastuzumab are still not fully understood and presents a significant challenge in clinical practice. In this study, whole exome sequencing (WES) was performed on paired tumor tissues before trastuzumab treatment (at baseline) and at progressive disease (PD) in 23 GC patients. Clinicopathological and molecular features that may be associated with primary and/or acquired resistance to trastuzumab were identified. Lauren classification of intestinal type was associated with a more prolonged progression-free survival (PFS) than diffuse type (HR = 0.29, P = 0.019). Patients with low tumor mutation burden (TMB) showed significantly worse PFS, while high chromosome instability (CIN) was correlated with prolonged OS (HR = 0.27; P = 0.044). Patients who responded to treatment had a higher CIN than nonresponders, and a positive trend towards increasing CIN was observed as response improved (P = 0.019). In our cohort, the most common genes to acquire mutations are AURKA, MYC, STK11, and LRP6 with four patients each. We also discovered an association between clonal branching pattern and survival, with an extensive clonal branching pattern being more closely related to a shorter PFS than other branching patterns (HR = 4.71; P = 0.008). We identified potential molecular and clinical factors that provide insight regarding potential association to trastuzumab resistance in advanced HER2-positive GC patients.
Strengths, gaps, and future directions on the landscape of ethics-related research for spinal cord injury
Authors: Nuechterlein Anna , Feng Lydia , Yehia Alaa , Illes Judy 
Published: April 2023

AbstractSpinal cord injury (SCI) affects between 250,000–500,000 people globally each year. While the medical aspects of SCI have received considerable attention in the academic literature, discourse pertaining to its ethical implications is more limited. The experience of SCI is shaped by intersecting demographic and identity factors such as gender, race, and culture that necessitate an intersectional and value-based approach to ethics-related research that is properly situated in context. Given this background, we conducted a content analysis of academic studies exploring the perspectives and priorities of individuals with SCI published in peer-reviewed journals in the decade between 2012–2021. Terms pertaining to SCI and ethics were combined in a search of two major publication databases. We documented overall publication patterns, recruitment and research methods, reporting of demographic variables, and ethics-related discourse. Seventy (70) papers met inclusion criteria and were categorized by their major foci. Findings reveal a gap in reporting of participant demographics, particularly with respect to race and ethnicity, geographic background, and household income. We discuss these person-centered themes and gaps that must be closed in the reporting and supporting of SCI research.
Subtypes in addiction and their neurobehavioral profiles across three functional domains
Authors: Drossel Gunner , Brucar Leyla R. , Rawls Eric , Hendrickson Timothy J. , Zilverstand Anna 
Published: April 2023

AbstractRates of return to use in addiction treatment remain high. We argue that the development of improved treatment options will require advanced understanding of individual heterogeneity in Substance Use Disorders (SUDs). We hypothesized that considerable individual differences exist in the three functional domains underlying addiction—approach-related behavior, executive function, and negative emotionality. We included N = 593 participants from the enhanced Nathan Kline Institute-Rockland Sample community sample (ages 18–59, 67% female) that included N = 420 Controls and N = 173 with past SUDs [54% female; N = 75 Alcohol Use Disorder (AUD) only, N = 30 Cannabis Use Disorder (CUD) only, and N = 68 Multiple SUDs]. To test our a priori hypothesis that distinct neuro-behavioral subtypes exist within individuals with past SUDs, we conducted a latent profile analysis with all available phenotypic data as input (74 subscales from 18 measures), and then characterized resting-state brain function for each discovered subtype. Three subtypes with distinct neurobehavioral profiles were recovered (p < 0.05, Cohen’s D: 0.4–2.8): a “Reward type” with higher approach-related behavior (N = 69); a “Cognitive type” with lower executive function (N = 70); and a “Relief type” with high negative emotionality (N = 34). For those in the Reward type, substance use mapped onto resting-state connectivity in the Value/Reward, Ventral-Frontoparietal and Salience networks; for the Cognitive type in the Auditory, Parietal Association, Frontoparietal and Salience networks; and for the Relief type in the Parietal Association, Higher Visual and Salience networks (pFDR < 0.05). Subtypes were equally distributed amongst individuals with different primary SUDs (χ2 = 4.71, p = 0.32) and gender (χ2 = 3.44, p = 0.18). Results support functionally derived subtypes, demonstrating considerable individual heterogeneity in the multi-dimensional impairments in addiction. This confirms the need for mechanism-based subtyping to inform the development of personalized addiction medicine approaches.