bluuebunny/crossref_metadata_2025_split huggingface dataset:
Empathy Expression in Interpreted and Noninterpreted Care Conferences of Seriously Ill Children
Authors: Olszewski Aleksandra E. , Bogetz Jori , Mercer Amanda , Bradford Miranda C. , Scott Maya , Fields Blanca , Williams Kelli , Rosenberg Abby R. , Trowbridge Amy 
Published: February 2023

BACKGROUND AND OBJECTIVES
Clinician empathy is associated with improved communication and clinical outcomes. We hypothesized that, when clinicians express empathy, families are more likely to deepen discussions, and that clinicians express less empathy in care conferences with language interpretation.

METHODS
Prospective, mixed methods cohort study of English and interpreted audio-recorded transcripts of care conferences for pediatric patients with serious illness hospitalized at a single urban, quaternary medical institution between January 2018 and January 2021. Directed content analysis identified empathic opportunities, clinician empathetic statements or missed opportunities, and family responses. Clinician empathic statements were “buried” if immediately followed by more clinician medical talk. Descriptive analyses summarized demographics and codes. χ2 analyses summarized differences among language interpretation and family responses.

RESULTS
Twenty-nine patient–family dyads participated. Twenty-two (81%) family members were female. Eleven (39%) used language interpretation (8 Spanish, 2 Vietnamese, 1 Somali). Families created 210 empathic opportunities. Clinicians responded with unburied empathy 80 times (38%, no differences for English versus interpreted care conferences, P = .88). When clinicians buried empathy or missed empathic opportunities, families responded with alliance (agreement, gratitude, or emotional deepening) 14% and 15% of the time, respectively. When clinicians responded with unburied empathy, families responded with alliance 83% of the time (P &lt; .01).

CONCLUSIONS
Our study suggests that clinician empathic expression does not differ when language interpretation is used in pediatric care conferences. Clinicians often miss opportunities to express empathy, or they bury it by medical talk. Although unburied empathy created opportunities for relationship-building and family-sharing, buried empathy negatively impacted these domains similarly to no empathic expression.
Detección con feromonas de Duponchelia fovealis Zeller en fincas freseras de Costa Rica
Authors: Gonzalez-Fuentes Francisco , Rodríguez-Chinchilla Carlos , Arroyo-Vargas Abelardo Jesús , González-Herrera Allan 
Published: February 2023

Introducción. Duponchelia fovealis Z. es una plaga en la producción de cultivos en el continente europeo y en Estados Unidos. Ha sido detectada en producción fresera en Brasil, México y en una finca en el Cantón de Vásquez de Coronado, en San José, Costa Rica. Objetivo. Determinar la presencia y distribución de Duponchelia fovealis Z. en fincas freseras de Costa Rica. Materiales y métodos. Durante las épocas secas del 2020-2021 y 2021-2022, trampas cebadas con la feromona de D. fovealis fueron colocadas en la finca del reporte inicial en Vásquez de Coronado y en otras seis fincas localizadas en las principales regiones freseras de Costa Rica: La Cima de Dota, Llano Grande, Poás y Vara Blanca. Resultados. El monitoreo demostró que las poblaciones más altas estuvieron establecidas en la finca de Vásquez de Coronado, mientras que se obtuvieron capturas ocasionales en fincas como en La Cima de Dota en San José y dos en Llano Grande de Cartago. Conclusiones. Se determinó la presencia de D. fovealis Z. en Costa Rica, con distribución limitada. Ante esto se sugiere un análisis de riesgo de la plaga y la implementación de medidas que disminuyan la dispersión del insecto.
Hybrid MDA-ANFIS approach based control of grid connected solar system with nine level inverter wind energy conversion
Authors: Apparao A. , Chandra Sekhar G. 
Published: February 2023

AbstractA hybrid approach is proposed in this paper to achieve the load power requirement for grid connected hybrid photovoltaic wind system. The proposed approach is the combined execution of both the Modified Dragonfly Algorithm (MDA) and Adaptive Neuro-Fuzzy Interference System (ANFIS), hence it is called MDA-ANFIS. ANFIS approach is improved by the MDA approach to minimize the error functions. The main aim of the proposed approach is satisfying the load power requirement and obtains the maximum energy from the hybrid wind solar system. Through the modelling of operating modes of generation units, the proposed approach determines the switching states of the inverter. The MDA approach is utilized to generate the dataset and the data set is processed by ANFIS, which creates the control signal. By using the proposed approach, it was possible to minimize the system parameter radiation, external disturbances as well as optimally fulfill the load demand. The proposed method is activated in MATLAB/Simulink platform, and its performance is compared with existing methods.
Feedback‐based self‐learning in large‐scale conversational AI agents
Authors: Ponnusamy Pragaash , Ghias Alireza Roshan , Yi Yi , Yao Benjamin , Guo Chenlei , Sarikaya Ruhi 
Published: February 2023

AbstractToday, most of the large‐scale conversational AI agents such as Alexa, Siri, or Google Assistant are built using manually annotated data to train the different components of the system including automatic speech recognition (ASR), natural language understanding (NLU), and entity resolution (ER). Typically, the accuracy of the machine learning models in these components are improved by manually transcribing and annotating data. As the scope of these systems increase to cover more scenarios and domains, manual annotation to improve the accuracy of these components becomes prohibitively costly and time consuming. In this paper, we propose a system that leverages customer/system interaction feedback signals to automate learning without any manual annotation. Users of these systems tend to modify a previous query in hopes of fixing an error in the previous turn to get the right results. These reformulations, which are often preceded by defective experiences caused by either errors in ASR, NLU, ER, or the application. In some cases, users may not properly formulate their requests (e.g., providing partial title of a song), but gleaning across a wider pool of users and sessions reveals the underlying recurrent patterns. Our proposed self‐learning system automatically detects the errors, generates reformulations, and deploys fixes to the runtime system to correct different types of errors occurring in different components of the system. In particular, we propose leveraging an absorbing Markov Chain model as a collaborative filtering mechanism in a novel attempt to mine these patterns, and coupling it with a guardrail rewrite selection mechanism that reactively evaluates these fixes using feedback friction data. We show that our approach is highly scalable, and able to learn reformulations that reduce Alexa‐user errors by pooling anonymized data across millions of customers. The proposed self‐learning system achieves a win‐loss ratio of 11.8 and effectively reduces the defect rate by more than 30 percent on utterance level reformulations in our production A/B tests. To the best of our knowledge, this is the first self‐learning large‐scale conversational AI system in production.
Utility of High Flow Nasal Oxygen versus Non-Invasive Ventilation in Severe Covid-19 Pneumonia: Retrospective Comparative Analysis and Assessment in Present Scenario Patients
Authors: Panse Neha Amey , Patil Kalyani Nilesh 
Published: February 2023

Background: The pandemic of COVID-19 since its beginning has created havoc all-round the globe. The role of oxygen therapy remains constant. Various modalities have been studied for oxygen delivery to hypoxic patients but high flow nasal oxygen (HFNO) has lately gained importance in terms of non-invasive oxygen delivery, easy administration and great improvement in patient’s recovery. We conducted this retrospective analysis with the primary objective of looking for the proportion of patients who were successfully weaned off of HFNO or non-invasive ventilation (NIV) and the secondary aim was to look for duration of hospital stay and its effect on clinical recovery based on laboratory parameters.
Methods: All patients, positive for COVID-19 infection by real-time reverse transcriptase polymerase chain reaction (RTPCR) were admitted to covid ICU or ward with oxygen requirement and were treated with either NIV or HFNO were enrolled for the study. Patients were grouped under H group (HFNO) or N group (NIV). Daily ABG readings, chest x-ray, respiratory rate, hemodynamic parameters and urine output were noted on 12 hourly intervals. Any changes in above parameters along with need for intubation were assessed.
Results: Patients from both the groups showed significant improvement in their oxygen saturation by the fifth day of their treatment. Fourteen patients from the NIV group and 10 from the HFNO group had saturation >90% by Day 5. Of those who presented with saturation of <85%, 2 out of 5 in the NIV group (40%) and 1 of the 2 patients in the HFNO group (50%) showed improvement in their oxygen saturation. The P/F was statistically comparable (p 0.928) in both groups. The levels of bio markers, and the improvement was comparable and correlated with clinical improvement as well.
Conclusion: We conclude that though HFNO is accepted better than NIV, the improvement in the respiratory status of the patient was comparable with both the treatment modalities and hence we do not recommend use of HFNO, especially in a situation of gross deficit of oxygen availability as compared to the exponential rise in the demand.
Investigação em omnichannel
Authors: DE CARVALHO GUILHERME JULIANI 
Published: February 2023

O omnichannel tem se mostrado como uma forte estratégia para fazer a integração dos diferentes canais do negócio, prezando pela melhoria na qualidade do atendimento e dos serviços ou produtos que a empresa oferece, a fim de melhorar a imagem de marca e cativar mais clientes. Neste contexto os objetivos desta revisão são: (i) elaborar uma linha do tempo sistemática sobre as publicações ao longo dos dez anos da existência do omnichannel mapeando o foco das pesquisas; (ii) destacar as mais recentes discussões sobre omnichannel e (iii) identificar a lacuna das pesquisas na relação entre omnichannel e consumidores (iv) sugerir caminhos para pesquisas futuras. Para tanto foi desenvolvida uma análise sistemática com identificação dos artigos mais citados na base de dados Scopus considerando as palavras-chave ‘omnichannel’, ‘omnichannel retail’ e ‘omnichannel retailing’. Este trabalho identifica a evolução da discussão do assunto ao longo dos anos e aponta como estudos mais recentes a experiência positiva do consumidor e a tomada de decisão em estratégia omnichannel. Entre os resultados nota-se um crescimento significativo das publicações sobre o tema nos últimos três anos e a maioria dos estudos são de origem estadunidense. Percebe-se, também, que a literatura sobre omnichannel ainda é muito esporádica, dispersa e fragmentada entre Journals, autores e linhas de pesquisa. Uma exaustiva literatura sobre a integração e gestão dos canais utilizados pelas organizações é encontrada, porém, conclui-se, que existe uma lacuna na literatura que estude a visão dos consumidores de forma mais aprofundada, destacando a percepção dos riscos envolvidos no omnichannel.
Przygotowanie Krakowa do obrony przed atakiem armii arcyksięcia Maksymiliana Habsburga w roku 1587
Authors: Zinkiewicz Jacek 
Published: February 2023

Do najważniejszych momentów w dziejach Rzeczypospolitej Obojga Narodów należą wydarzenia z 1587 r. – czas bezkrólewia po śmierci Stefana Batorego i wybór nowego władcy. Miały one fundamentalne znaczenie dla polskiej polityki wewnętrznej, a przede wszystkim międzynarodowej. Gdy zgromadzona w Warszawie szlachta w sierpniu 1587 r. dokonała podwójnej elekcji, rozpoczął się wyścig Zygmunta Wazy i Maksymiliana Habsburga o koronę królewską. Kraków jako stolica kraju odegrał w tych wydarzeniach kluczową rolę.
Rachunki miejskie oraz liczne źródła, głównie narracyjne, ilustrują przebieg przygotowań Krakowa do obrony murów i odparcia austriackiego pretendenta do tronu. Rozproszone informacje wykazują pewną prawidłowość. Na przykład można zaobserwować wzmożoną aktywność, zwłaszcza wokół bram, które odgrywały kluczową rolę w systemie obronnym miasta.
Niniejszy artykuł podejmuje próbę spojrzenia na problem złożonych i żmudnych przygotowań miasta do jego obrony. Dotychczasowa historiografia nie ukazywała omawianych wydarzeń z punktu widzenia zaplecza logistycznego i technicznego. Dzięki dostępnym źródłom, możemy poznać sposoby funkcjonowania rzemiosła obronnego, począwszy od stosowanych narzędzi pracy – przez architekturę obronną – aż po strategię.
Does Using a Mindfulness App Reduce Anxiety and Worry? A Randomized-Controlled Trial
Authors: Abbott Deah , Lack Caleb W. , Anderson Page 
Published: February 2023

Objectives:the availability of smartphone-based mindfulness training applications (apps) may circumvent many barriers to receiving in-person help, but little controlled research has been conducted on them. This study sought to evaluate the effectiveness of a widely used ­mindfulness training app, Headspace, at reducing anxiety and worry.Methods:this study used a randomized-controlled design to examine the app using a 3 (Time; baseline, 4 weeks, 8 weeks) × 2 (Access; immediate, delayed for 4 weeks) design. Participants who reported moderate to high anxiety or worry were randomly assigned to receive ­either ­immediate access or delayed access to the app. For null hypothesis significance testing (NHST), analyses of variance were used to test the hypotheses that app access for 4 and 8 weeks would reduce anxiety and worry as compared to waitlist or baseline and that app access for 8 weeks would reduce anxiety and worry as compared to 4 weeks. Bayes estimates were used to ­determine the level of evidence for the hypothesis that app access reduces anxiety and worry.Results:four weeks of app access significantly reduced anxiety symptoms, as did 8 weeks, but NHST indicated there were no significant difference between 4 and 8 weeks of access. We failed to reject the null for the analysis of variance on worry, but Bayesian estimates indicated substantial evidence for the hypothesis that the mindfulness training app reduces worry.Conclusions:this research shows that using Headspace can reduce anxiety and worry, but that there does not appear to be a consistent dose relation.
STING-triggered CNS inflammation in human neurodegenerative diseases
Authors: Ferecskó Alex S. , Smallwood Miranda J. , Moore Adrian , Liddle Corin , Newcombe Jia , Holley Janet , Whatmore Jacqueline , Gutowski Nicholas J. , Eggleton Paul 
Published: February 2023

Abstract
Background: Some neurodegenerative diseases have an element of neuroinflammation that is triggered by viral nucleic acids, resulting in the generation of type I interferons. In the cGAS-STING pathway, microbial and host-derived DNA bind and activate the DNA sensor cGAS, the resulting cyclic dinucleotide, 2’3-cGAMP binds to a critical adaptor protein, stimulator of interferon genes (STING), which leads to activation of downstream pathway components. However, there is limited work demonstrating the activation of the cGAS- STING pathway in human neurodegenerative diseases.
Methods: Post-mortem CNS tissue from donors with multiple sclerosis (n=4), Alzheimer's diseases (n=6) and Parkinson's disease (n=3), amyotrophic lateral sclerosis (n=3) and non-neurodegenerative controls (n=11) were screened by immunohistochemistry for STING and relevant protein aggregates (e.g., amyloid-b, a-synuclein, TDP-43). Human brain endothelial cells were cultured and stimulated with the STING agonist palmitic acid (1-400µM) and assessed for mitochondrial stress (release of mitochondrial DNA into cytosol, increased oxygen consumption), and downstream regulator factors, TBK-1/pIRF3 and inflammatory biomarkers interferon-β release and changes ICAM-1 integrin expression.
Results: In neurodegenerative brain, elevated STING protein was observed mainly in brain endothelial cells and neurons compared to non-neurodegenerative control tissues where STING protein staining was weaker in comparison. Interestingly, higher STING presence was associated with toxic protein aggregates. (e.g., in neurons). Similarly high STING protein levels were observed within acute demyelinating lesions in multiple sclerosis subjects. To understand non-microbial/metabolic stress activation of the cGAS-STING pathway, brain endothelial cells were treated with palmitic acid. This evoked mitochondrial respiratory stress up to a ~2.5-fold increase in cellular oxygen consumption. Palmitic acid induced a statistically significant increase in cytosolic DNA leakage from endothelial cell mitochondria (Mander’s coefficient; P <0.05) and a significant increase in TBK-1, phosphorylated transcription factor IFN regulatory factor 3, cGAS, cell surface ICAM. In addition, a dose response in secretion of interferon-b was observed but failed to reach statistical significance.
Conclusions: The histological evidence show that the common cGAS-STING pathway appears to be activated in endothelial and neural cells in all four neurodegenerative diseases examined. Together with the in vitro data suggest that the STING pathway might be activated via perturbation of mitochondrial stress and DNA leakage resulting in downstream neuroinflammation hence this pathway may be a target for future STING therapeutics.
The effectiveness of interventions used to improve general health check uptake by the older adult population: a systematic review and meta-analysis
Authors: Lau Wing Yan , Lian Jinxiao , Yap Maurice 
Published: February 2023

Abstract
As the population ages, promoting good health maintenance practices has become an important strategy in many health systems. Regular general health checks detect common diseases and empower older adults to monitor their physical health. Yet the service uptake rate is low. Previous reviews have identified intervention methods to improve the uptake rate, but the overall effectiveness of these interventions remains unclear. This review aims to determine the overall effectiveness of the interventions used to improve general health check uptake and identify the behavior change techniques used in these interventions. Literature searches were conducted in four electronic databases in August 2020 and updated in May 2021. Six randomized controlled trials were included in this review. Seven intervention types were identified, including enhanced invitation letters, telephone invitation, question-behavior-effect questionnaire, financial incentive, leaflet, pre-notification, and SMS reminder. Overall, the interventions are effective, with an odds ratio of 1.21, and a 95% confidence interval between 1.09–1.33. Fifteen behavior change techniques were identified using the Behaviour Change Technique Taxonomy (v1). The findings suggest that the current interventions implemented in invitation methods are effective in improving the general health check uptake rate, but there are still opportunities to further improve the uptake rate by considering other intervention types. Future studies could consider how other intervention types could be implemented alone or with the enhanced invitation methods to maximize the service uptake rate. The systematic review protocol is registered on PROSPERO (ref: CRD42021221041).
ZFHX3 acts as a tumor suppressor in prostate cancer by targeting FTO-mediated m6A demethylation
Authors: Hu Qingxia , yin junling , zhao sijie , wang yibo , Yan Keqiang , huang shuhong 
Published: February 2023

Abstract

Zinc-finger homeobox 3 (ZFHX3, also known as ATBF1) suppresses prostatic tumorigenesis; ZFHX3 is frequently found to have numerous deletions when found in human prostate cancer (PCa). However, the underlying molecular function of ZFHX3 during prostatic tumorigenesis is not well understood. N6-methyladenosine (m6A) modification in RNA plays a critical role in the development of cancers; however, the relationship between ZFHX3 and m6A modification is largely unknown in PCa. In this study, we found that ZFHX3 knockdown decreased total m6A levels through enhancing the transcriptional activity of FTO in PCa cells. Importantly, FTO inhibition suppressed cell proliferation and rescued the promoting function of ZFHX3 knockdown on cell proliferation. Through transcriptome sequencing and Me-RIP sequencing, we revealed that E2F2 and CDKN2C were the direct targets of FTO-mediated m6A modification and identified the role of E2F2 and CDKN2C in cell cycle arrest in FTO-depleted cells. Interestingly, ZFHX3 expression was in return regulated by FTO in m6A-dependent way. In vivo, we verified that FTO was upregulated and ZFHX3 was decreased in PCa patients and that a high level of ZFHX3 is indispensable for low FTO expression and is correlated with better patient survival. These findings establish a novel crosstalk mechanism between ZFHX3 and FTO in prostatic tumorigenesis.
Comparison of the Effectiveness of Family-Focused Therapy and Social Cognition and Interaction Training in Preventing the Relapse of Bipolar Disorder and Improving the Patient’s Interpersonal Relationships and Components Related to Social Functioning: Randomized Clinical Trial
Authors: Tabas Maryam Yousefi , Momeni Fereshte , Bakhshani Nour Mohammad , Pourshahbaz Abbas , Rezaei Omid , Bagajan Kaveh Qaderi 
Published: February 2023

Abstract

Background:Bipolar disorder type I (BD-I) is characterized by periodic mood swings, including mania and depression. Family stress and cognitive defects are among the important factors in the relapse of this disorder. The present study aimed to investigate the effectiveness of family-focused therapy (FFT) and social cognitive and interaction training (SCIT) in preventing BD-I relapse and improving the patient’s interpersonal relationships and components related to social functioning.Methods:This quasi-experimental study had a controlled, pretest-posttest, and three-month follow-up design. Sixty patients with BD-I, hospitalized in Zahedan Psychiatric Hospital (Zahedan, Iran), as well as one of their primary caregivers, were selected purposefully based on the inclusion criteria and randomly assigned to three groups. A total of 56 individuals completed all the study questionnaires until the follow-up. The SCIT group (consisting of only patients) and the FFT group (consisting of patients with a primary caregiver) each participated in 15 sessions of group interventions. The research tools were completed before the intervention, after the first session of the intervention, after the intervention, and in the follow-up.Results:The present results showed that the SCIT and FFT could equally improve relapse prevention and promote social functioning and its components, except for the component of interpersonal relationships, where SCIT was more effective than FFT in the posttest (β=3,P=0.034) and follow-up (β=5.043,P=0.001).Conclusion:According to the present results, since FFT is an evidence-based treatment for BD-I patients, SCIT can be used along with this intervention, as simultaneous attention to environmental factors and social cognitive defects can provide an opportunity to improve the social functioning of patients with BD-I, especially their interpersonal relationships.