bluuebunny/crossref_metadata_2025_split huggingface dataset:
SURGICAL RIB FRACTURE FIXATION IN THE NORTH OF SCOTLAND: EARLY OPERATIVE INTERVENTION IMPROVES OUTCOMES
Authors: Dixon J. E. , Rankin I. A. , Diston N. , Goffin J. , Stevenson I. 
Published: March 2023

This study aimed to assess the outcomes of patients with complex rib fractures undergoing operative or non-operative management at our center over a six-year time period.Retrospective analysis was performed to identify all patients with complex rib fractures at our center from May 2016 to September 2022. Outcome measures included mechanical ventilation, tracheostomy, pneumonia, and mortality at one year.388 patients with complex rib fractures were identified. 37 (10%) patients fulfilled criteria for surgical management and underwent rib fracture fixation; 351 patients were managed non-operatively with anaesthetic block or analgesia alone. The fixation group had a significantly higher proportion of patients with flail chest (30 (81%) vs 94 (27%), p<0.001) and were significantly more likely to require ICU admission (30 (81%) vs. 16 (5%), p<0.001) than the non-operative group. At one year follow-up, no significant differences were seen for mortality between these groups (1 (3%) vs. 27 (7%), p=0.276).Of the surgical management group, those that underwent fixation <72 hours post injury were significantly less likely to develop pneumonia than those who were delayed >72 hours (2 (18%) vs 15 (58%), p=0.038), with downward trends noted for ICU length of stay (6 vs 10 days, p=0.140) and duration of mechanical ventilation (5 vs 8 days, p=0.177); no significant differences were seen for tracheostomy (3 vs. 5, p=0.588) or mortality (0 vs 1, p=0.856).Surgical fixation of complex rib fractures improves outcomes in selected patient groups. Early surgical fixation led to reduced rates of pneumonia and may improve other outcome measures.
Estrategia de competitividad turística de la República Dominicana
Authors: Villareal René , Van der Horst Andrés 
Published: March 2023

El turismo es la actividad económica más importante de República Dominicana que bien puede – como ha sido la experiencia exitosa de otros destinos turísticos- ampliar sus efectos positivos a una mayor equidad en la distribución del ingreso y desde luego a disminuir la pobreza.Dado que el turismo es el motor indiscutible del crecimiento económico y, sobre todo, una fuente importante de empleo con amplio impacto en las comunidades locales puede y debe contribuir a mejorar la calidad de vida de la población más pobre del país a través de su integración al desarrollo turístico.La estrategia general del modelo para avanzar hacia una nueva etapa del desarrollo turístico competitivo y sustentable se detalla en el Plan Nacional de Competitividad Sistemática de República Dominicana (PNCS-RD), el cual fue presentado por el Presidente Dr. Leonel Fernández el 21 de marzo de 2007. En este artículo se presenta un panorama de la estrategia general sugerida para diversificar el modelo de desarrollo turística de la República Dominicana.
De smart city a smart destination. El caso de tres ciudades canadienses
Authors: Khomsi Mohamed Reda , Bédard Bedard François 
Published: March 2023

Varias ciudades en el mundo se autoproclaman “inteligentes” integrando, en diferentes grados las nuevas tecnologías en las diferentes esferas de la ciudad. Sin embargo, a pesar de esta efervescencia alrededor de la ciudad inteligente, el concepto requiere más conceptualización por parte de los investigadores. Esto es aún más importante cuando llega el momento de distinguir entre una ciudad inteligente y un destino inteligente. La relación entre estos dos conceptos no es clara y la transición de ciudad inteligente a destino inteligente no es automática. Esta situación se explica por el hecho que las características intrínsecas de sus respectivas poblaciones objetivo, tanto de los ciudadanos como de los turistas son diferentes. En este orden, este artículo compara tres ciudades Canadienses de la provincia de Quebec, con el objetivo de demostrar que la realización de un proyecto de destino inteligente, requiere la adaptación de las estructuras de gobierno, la participación de todos los interesados y particularmente en turismo.
Optimization and characterization of toroidal foci for super-resolution fluorescence microscopy: tutorial
Authors: Lopez Lucía F. , Masullo Luciano A. , Szalai Alan M. , Edorna Florencia , Choque Florencia D. , Caprile Fernando , Stefani Fernando D. 
Published: March 2023

Single-molecule localization microscopy (SMLM) has become an essential tool to investigate phenomena at the nanoscale. Among the different SMLM approaches, methods that interrogate the molecular position with an intensity minimum, such as minimal emission fluxes (MINFLUX) or the more recent raster scanning a minimum of light (RASTMIN), stand out for reaching true molecular resolution. To implement these methods, the phase of the excitation beam needs to be modulated to obtain a focus with a central minimum, i.e., a so-called toroidal or doughnut-shaped focus. In this tutorial, we explain the basis and experimental tricks to generate and optimize such beams, particularly in raster-scanning microscopes.
The efficacy and safety of sodium nitroprusside in the treatment of schizophrenia: Protocol for an updated systematic review and meta-analysis
Authors: Fei Xinxing , Wang Shiqi , Li Jiyang , Wang Jianxiong , Gao Yaqian , Hu Yue 
Published: March 2023

Background
Schizophrenia is a chronic persistent disease with high recurrence rate and high disability rate in the field of psychiatry. Sodium nitroprusside is a nitric oxide (NO) donor and considered a promising new compound for the treatment of schizophrenia. New high-quality clinical trials of sodium nitroprusside in the treatment of schizophrenia have been published in recent years. It is necessary to re-conduct the meta-analysis after the inclusion of these new clinical trials. Our study will conduct a systematic review and meta-analysis of the relevant literature in this field, so as to lay an evidence-based medicine foundation for the efficacy of sodium nitroprusside in the treatment of schizophrenia.

Methods and analysis
Randomized controlled trials (RCTs) of sodium nitroprusside in the treatment of schizophrenia were searched through English databases (PubMed, Web of Science, Embase, and Cochrane Library) and Chinese databases (China Biology Medicine disc, VIP, WanFang Data, and CNKI). The extracted data will be inputted into Review Manager 5.3 for Meta-analysis. The included literature will be assessed for bias risk according to the bias risk assessment tools in the Cochrane Handbook for Systematic Reviews of Interventions. Funnel plots will be used to assess possible publication bias. Heterogeneity is tested by I2 and χ2 tests, and the existence of heterogeneity is defined as I2 ≥50% and P ≤0.1. If heterogeneity exists, the random-effect model will be used, and sensitivity analysis or subgroup analysis will be performed to further determine the source of heterogeneity.

Prospero registration number
CRD42022341681.
Hybrid, High-Dose Dual and Bismuth Quadruple Therapies for First-Line Treatment of Helicobacter pylori Infection in Taiwan: A Multicenter, Open-Label, Randomized Trial
Authors: Hsu Ping-I , Chen Kuan-Yang , Tai Wei-Chen , Yang Jyh-Chin , Tsay Feng-Woei , Liu Yu-Hwa , Chen Chien-Lin , Lee Chia-Long , Yeh Hong-Zen , Kuo Chao-Hung , Chuah Seng-Kee , Lee Hsi-Chang , Shie Chang-Bih , Shiu Sz-Iuan , Kao John Y. , Yamaoka Yoshio , Graham David Y. , Wu Deng-Chyang ,   On behalf of the Taiwan Acid-related Disease (TARD) Study Group
Published: March 2023

INTRODUCTION:
The study aimed to compare the efficacies and safety of 14-day hybrid therapy, 14-day high-dose dual therapy, and 10-day bismuth quadruple therapy in the first-line treatment of Helicobacter pylori infections.

METHODS:
In this multicenter, open-label, randomized trial, we recruited adult H. pylori-infected patients from 9 centers in Taiwan. Subjects were randomly assigned (1:1:1) to 14-day hybrid therapy, 14-day high-dose dual therapy, or 10-day bismuth quadruple therapy. Eradication status was determined by the 13C-urea breath test. The primary outcome was the eradication rate of H. pylori assessed in the intention-to-treat population.

RESULTS:
Between August 1, 2018, and December 2021, 918 patients were randomly assigned in this study. The intention-to-treat eradication rates were 91.5% (280/306; 95% confidence interval [CI] 88.4%–94.6%) for 14-day hybrid therapy, 83.3% (255/306; 95% CI 87.8%–95.0%) for 14-day high-dose dual therapy, and 90.2% (276/306; 95% CI 87.8%–95.0%) for 10-day bismuth quadruple therapy. Both hybrid therapy (difference 8.2%; 95% CI 4.5%–11.9%; P = 0.002) and bismuth quadruple therapy (difference 6.9%; 95% CI 1.6%–12.2%; P = 0.012) were superior to high-dose dual therapy and were similar to one another. The frequency of adverse events was 27% (81/303) with 14-day hybrid therapy, 13% (40/305) with 14-day high-dose dual therapy, and 32% (96/303) with 10-day bismuth quadruple therapy. Patients receiving high-dose dual therapy had the fewest adverse events (both P < 0.001).

DISCUSSION:
Fourteen-day hybrid therapy and 10-day bismuth quadruple therapy are more effective than 14-day high-dose dual therapy in the first-line treatment of H. pylori infection in Taiwan. However, high-dose dual therapy has fewer adverse effects than hybrid bismuth quadruple therapies.
CS-iCCA, A New Clinically Based Staging System for Intrahepatic Cholangiocarcinoma: Establishment and External Validation
Authors: Lozada Maria E. , Zhang Ning , Jin Weidong , Wongjarupong Nicha , Yang Ju Dong , Voss Molly M. , Prasai Kritika , Amakye Dominic O. , Harmsen William S. , Chaudhary Sushant , Bathe Oliver F. , Borad Mitesh J. , Patel Tushar C. , Gores Gregory J. , Therneau Terry M. , Roberts Lewis R. 
Published: March 2023

INTRODUCTION:
Intrahepatic cholangiocarcinoma (iCCA) is a primary liver malignancy with poor prognosis. Current prognostic methods are most accurate for patients with surgically resectable disease. However, a significant proportion of patients with iCCA are not surgical candidates. We aimed to develop a generalizable staging system based on clinical variables to determine prognosis of all patients with iCCA.

METHODS:
The derivation cohort included 436 patients with iCCA seen between 2000 and 2011. For external validation, 249 patients with iCCA seen from 2000 to 2014 were enrolled. Survival analysis was performed to identify prognostic predictors. All-cause mortality was the primary end point.

RESULTS:
Eastern Cooperative Oncology Group status, tumor number, tumor size, metastasis, albumin, and carbohydrate antigen 19-9 were incorporated into a 4-stage algorithm. Kaplan-Meier estimates for 1-year survival were 87.1% (95% confidence interval [CI] 76.1–99.7), 72.7% (95% CI 63.4–83.4), 48.0% (95% CI 41.2–56.0), and 16% (95% CI 11–23.5), respectively, for stages I, II, III, and IV. Univariate analysis yielded significant differences in risk of death for stages II (hazard ratio [HR] 1.71; 95% CI 1.0–2.8), III (HR 3.32; 95% CI 2.07–5.31), and IV (HR 7.44; 95% CI 4.61–12.01) compared with stage I (reference). Concordance indices showed the new staging system was superior to the TNM staging for predicting mortality in the derivation cohort, P < 0.0001. In the validation cohort, however, the difference between the 2 staging systems was not significant.

DISCUSSION:
The proposed independently validated staging system uses nonhistopathologic data to successfully stratify patients into 4 stages. This staging system has better prognostic accuracy compared with the TNM staging and can assist physicians and patients in treatment of iCCA.
Fano fourfolds having a prime divisor of Picard number 1
Authors: Secci Saverio Andrea 
Published: March 2023

Abstract
We prove a classification result for smooth complex Fano fourfolds of Picard number 3 having a prime divisor of Picard number 1, after a characterisation result in arbitrary dimension by Casagrande and Druel [5]. These varieties are obtained by blowing-up a ℙ1-bundle over a smooth Fano variety of Picard number 1 along a codimension 2 subvariety. We study in detail the case of dimension 4, and show that they form 28 families. We compute the main numerical invariants, determine the base locus of the anticanonical system, and study their deformations to give an upper bound to the dimension of the base of the Kuranishi family of a general member.
Enhanced sensitive phase alpha plane scheme against high resistance ground faults
Authors: Gangolu Suryanarayana , Sarangi Saumendra 
Published: March 2023

AbstractPhase-based Alpha (α) Plane Relaying (APR) scheme has numerous advantages over the Current Differential Relay (CDR) for transmission line protection. Since the large Restraining Region (RR) in the APR makes high security against CT saturation, channel delay, line charging current and synchronization error. However, the APR loses its sensitivity for high resistance ground faults, especially single line to ground faults under outfeed conditions. Also, losing its dependability under close-in low resistance three-phase faults. Thereby, the sequence-based APR provides enhanced sensitivity with the cost of computational burden and complexity. Hence, in this paper, the concept of the average value (IAvg) of both end instantaneous currents is used as an auxiliary logic. In which, the polarity ofIAvgis incorporated as an add-on logic to the conventional APR to confirm high resistance internal faults. Thereby, the requirement of sequence components can be avoided (negative and zero). To validate the proposed auxiliary logic, it is tested for the WSCC (Western System Coordinating Council) 9-bus, 110 kV, 50 Hz. System. The simulated results under various fault cases found authenticated results. In addition, the comparative assessment and validation with real-world data reveal the enhanced sensitivity of the proposed logic under high-resistance ground faults.
A gap-filling algorithm selection strategy for GRACE and GRACE Follow-On time series based on hydrological signal characteristics of the individual river basins
Authors: Karimi Hamed , Iran-Pour Siavash , Amiri-Simkooei Alireza , Babadi Masoud 
Published: March 2023

Abstract
Gravity recovery and climate experiment (GRACE) and GRACE Follow-On (GRACE-FO) are Earth’s gravity satellite missions with hydrological monitoring applications. However, caused by measuring instrumental problems, there are several temporal missing values in the dataset of the two missions where a long gap between the mission dataset also exists. Recent studies utilized different gap-filling methodologies to fill those data gaps. In this article, we employ a variety of singular spectrum analysis (SSA) algorithms as well as the least squares-harmonic estimation (LS-HE) approach for the data gap-filling. These methods are implemented on six hydrological basins, where the performance of the algorithms is validated for different artificial gap scenarios. Our results indicate that each hydrological basin has its special behaviour. LS-HE outperforms the other algorithms in half of the basins, whereas in the other half, SSA provides a better performance. This highlights the importance of different factors affecting the deterministic signals and stochastic characteristics of climatological time series. To fill the missing values of such time series, it is therefore required to investigate the time series behaviour on their time-invariant and time-varying characteristics before processing the series.
HeterozygousDab1Null Mutation Disrupts Neocortical and Hippocampal Development
Authors: Honda Takao , Hirota Yuki , Nakajima Kazunori 
Published: March 2023

AbstractLoss-of-function mutations in Reelin and DAB1 signaling pathways disrupt proper neuronal positioning in the cerebral neocortex and hippocampus, but the underlying molecular mechanisms remain elusive. Here, we report that heterozygousyotarimice harboring a single autosomal recessiveyotarimutation ofDab1exhibited a thinner neocortical layer 1 than wild-type mice on postnatal day (P)7. However, a birth-dating study suggested that this reduction was not caused by failure of neuronal migration.In uteroelectroporation-mediated sparse labeling revealed that the superficial layer neurons of heterozygousyotarimice tended to elongate their apical dendrites within layer 2 than within layer 1. In addition, the CA1 pyramidal cell layer in the caudo-dorsal hippocampus was abnormally split in heterozygousyotarimice, and a birth-dating study revealed that this splitting was caused mainly by migration failure of late-born pyramidal neurons. Adeno-associated virus (AAV)-mediated sparse labeling further showed that many pyramidal cells within the split cell had misoriented apical dendrites. These results suggest that regulation of neuronal migration and positioning by Reelin-DAB1 signaling pathways has unique dependencies onDab1gene dosage in different brain regions.
Változások és újítások a Minnesota Multiphasic Personality Inventory-2 (MMPI-2) pszichodiagnosztikai tesztben
Authors: Girasek Hunor , Soós Alexandra , Janicsák Henrietta , Dudás Dóra , Reinhardt Melinda 
Published: March 2023

BevezetésA Minnesota Multiphasic Inventory (MMPI) Magyarországon az 1970-es évek óta használatos pszichodiagnosztikai mérőeszköz, melynek második kiadása (MMPI-2) 1989-ben jelent meg a nemzetközi használatban, Magyarországon pedig 2009-ben készült el az adaptációja.CélkitűzésJelen tanulmány célja, hogy bemutassa az MMPI-2-ben megjelent változásokat, újításokat és a teszt előnyeit a korábbi változatához képest.KövetkeztetésekA téma-összefoglaló tanulmány rávilágít, hogy az MMPI-2 kifejlesztése nemcsak új normatív mintát, de nyelvi-stilisztikai megújulást is hozott. Ezenfelül a korábbi Validitási és Klinikai skálák mellett olyan új skálák is megjelentek, mint az Újrastrukturált klinikai skálák, a Tartalmi skálák és a személyiségpszichopatológia mérésére alkalmas PSY-5 skálák. Megtörtént továbbá a Kiegészítő skálák revíziója, illetve új Kiegészítő skálák bevezetése és új Validitási skálák kifejlesztése is.KonklúzióA változtatások részletes számbavétele rámutat arra, hogy az MMPI újrasztenderdizálása során kialakított MMPI-2 jóval átfogóbb, egyben differenciáltabb értelmezést kínál a különböző mentális zavarok és pszichopatológiai jelenségek megértése szempontjából, mint az eredeti változat. Kitekintésként pedig ismertetésre kerül a nemzetközi gyakorlatba már bevezetett két új MMPI-fejlesztés, az MMPI-2-Resturctured Form (MMPI-2-RF) és az MMPI-3 is.
A hybrid DMO-RERNN based UPFC controller for transient stability analysis in grid connected wind-diesel-PV hybrid system
Authors: Thanigaivel K. , Ramesh S. , Karunanithi K. 
Published: March 2023

AbstractIn this paper, a novel hybrid technique is proposed for transient stability analysis on grid connected Wind-Diesel-PV hybrid system. The proposed hybrid methodology is combination of the dwarf mongoose optimization algorithm (DMO) and the recalling enhanced recurrent neural network (RERNN) named DMO-RERNN. The main purpose of this work is to consider various elements on hybrid system for the analysis of transient stability according to different conditions. The voltage profile of hybrid system is enhanced using the proposed unified power flow controller (UPFC), which also has higher performance improving transient performance compared to the conventional ANN, PI and fuzzy-sliding mode controller. Considering the proposed technique, DMO is used to find the optimal global solution for the fault predicted by the RERNN approach. The proposed system is executed on MATLAB work platform; its performance with existing systems is analyzed. The result proves that the proposed hybrid technique based UPFC controller provides better results compared with other existing technique. The efficiency of the PI is 82.136, ANN is 77, Fuzzy Sliding Mode is 65.097% and proposed technique is 97.99038%.
Opportunities for the materials research community to support the development of the H2 economy
Authors: Ku Anthony Y. , Kocs Elizabeth A. , Afzal Shaik , Ewan Mitch , Glenn Jennifer R. , Toma Francesca , Vickers James , Weeks Brian , White Ashley A. 
Published: March 2023

AbstractThe goal of decarbonizing global energy systems by 2050 is a challenge of unprecedented scope and ambition. Hydrogen has been identified as an important enabler for this effort, but its precise role in the energy transition and future energy system remains unclear. The MRS Focus on Sustainability subcommittee sponsored a panel discussion on the roles of and materials needs associated with hydrogen in the energy transition. This commentary summarizes key elements from the panel discussion and addresses how the materials research community can engage more deeply with the H2 energy transition. The topics include inventing new materials with improved properties for advanced technologies, but also supporting the growth of a robust manufacturing base, improving materials corrosion mitigation, helping to de-risk supply chains, and training qualified workers across the industrial ecosystem to reinforce a culture of safety and support the evolution of commercial processes and business models.

Graphical abstract
Unsur Lokal Nusantara dalam Syarah Hadis: Studi Kitab Tarjamah Bulughul Maram Karya Ahmad Hassan
Authors: Bisri Kasan , Soebahar Moh. Erfan , Ulama’i A. Hassan Asy’ari 
Published: March 2023

Hadith commentary (sharḥ) is the result of dynamic ijtihad which has a dialectical relation with the socio-historical conditions of the commentator (shāriḥ). This paper aims to examine the existence of social dialectics and the interrelated subjectivity of authorship in hadith commentary, namely Tarjamah Bulughul Maram Ibnu Hajar al-Asqalani Terjemahan Beserta Keterangannya written by Ahmad Hassan. It discusses two issues: 1) on the motivation of Ahmad Hassan’s authorship in writing the book Tarjamah Bulughul Maram; 2) on the local values ​​which are manifested in the book. By using descriptive-analytical method and interpretive approach, this paper argues two conclusions. First, the background of the authorship of the hadith commentary is inseparable from Hassan’s response to social conditions that require explanations of the Bulūgh al-Marām. In addition, he also interested in disseminating the notion of Islamic renewal through his work. Second, local elements of the archipelago which are manifested in his commentary book, including: local language, appreciation of local treasures, response to local traditions, and legal provisions.

Syarah hadis merupakan hasil ijtihad yang dinamis dan selalu memiliki hubungan dialektis dengan kondisi sosio-historis penulisnya (shāriḥ). Tulisan ini hendak menunjukan eksistensi dialektika sosial dan subjektivitas kepengarangan yang saling bertautan. Dengan menjadikan Tarjamah Bulughul Maram Ibnu Hajar al-Asqalani Terjemahan Beserta Keterangannya yang ditulis oleh Ahmad Hassan sebagai objek kajian, artikel ini hendak mendiskusikan dua hal, yaitu: 1) tentang motivasi kepengarangan Ahmad Hassan dalam menulis kitab Tarjamah Bulughul Maram? 2) tentang nilai-nilai lokal yang termanifestasikan dalam kitab syarah tersebut. Dengan menggunakan metode deskriptif-analitis dan pendekatan interpretatif, tulisan ini menemukan dua kesimpulan. Pertama, latar kepengarangan syarah hadis tersebut tidak terlepas dari respon Hassan terhadap kondisi sosial yang membutuhkan penjelasan atas kitab Bulūgh al-Marām. Selain itu, Hassan juga memiliki kepentingan untuk mendiseminasikan paham pembaharuan Islam melalui karyanya tersebut. Kedua, unsur lokal Nusantara yang termanifestasikan dalam kitab syarah tersebut, di antaranya: bahasa lokal, apresiasi khazanah lokal, respon terhadap tradisi lokal, dan ketentuan hukum.