bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reaching Populations at Risk for HIV Through Targeted Facebook Advertisements: Cost-Consequence Analysis
Authors: Hanna John J , Saleh Sameh N , Lehmann Christoph U , Nijhawan Ank E , Medford Richard J 
Published: January 2023

Background
An undiagnosed HIV infection remains a public health challenge. In the digital era, social media and digital health communication have been widely used to accelerate research, improve consumer health, and facilitate public health interventions including HIV prevention.

Objective
We aimed to evaluate and compare the projected cost and efficacy of different simulated Facebook (FB) advertisement (ad) approaches targeting at-risk populations for HIV based on new HIV diagnosis rates by age group and geographic region in the United States.

Methods
We used the FB ad platform to simulate (without actually launching) an automatically placed video ad for a 10-day duration targeting at-risk populations for HIV. We compared the estimated total ad audience, daily reach, daily clicks, and cost. We tested ads for the age group of 13 to 24 years (in which undiagnosed HIV is most prevalent), other age groups, US geographic regions and states, and different campaign budgets. We then estimated the ad cost per new HIV diagnosis based on HIV positivity rates and the average health care industry conversion rate.

Results
On April 20, 2021, the potential reach of targeted ads to at-risk populations for HIV in the United States was approximately 16 million for all age groups and 3.3 million for age group 13 to 24 years, with the highest potential reach in California, Texas, Florida, and New York. When using different FB ad budgets, the daily reach and daily clicks per US dollar followed a cumulative distribution curve of an exponential function. Using multiple US $10 ten-day ads, the cost per every new HIV diagnosis ranged from US $13.09 to US $37.82, with an average cost of US $19.45. In contrast, a 1-time national ad had a cost of US $72.76 to US $452.25 per new HIV diagnosis (mean US $166.79). The estimated cost per new HIV diagnosis ranged from US $13.96 to US $55.10 for all age groups (highest potential reach and lowest cost in the age groups 20-29 and 30-39 years) and from US $12.55 to US $24.67 for all US regions (with the highest potential reach of 6.2 million and the lowest cost per new HIV diagnosis at US $12.55 in the US South).

Conclusions
Targeted personalized FB ads are a potential means to encourage at-risk populations for HIV to be tested, especially those aged 20 to 39 years in the US South, where the disease burden and potential reach on FB are high and the ad cost per new HIV diagnosis is low. Considering the cost efficiency of ads, the combined cost of multiple low-cost ads may be more economical than a single high-cost ad, suggesting that local FB ads could be more cost-effective than a single large-budget national FB ad.
Increasing Engagement in the Electronic Framingham Heart Study: Factorial Randomized Controlled Trial
Authors: Trinquart Ludovic , Liu Chunyu , McManus David D , Nowak Christopher , Lin Honghuang , Spartano Nicole L , Borrelli Belinda , Benjamin Emelia J , Murabito Joanne M 
Published: January 2023

Background
Smartphone apps and mobile health devices offer innovative ways to collect longitudinal cardiovascular data. Randomized evidence regarding effective strategies to maintain longitudinal engagement is limited.

Objective
This study aimed to evaluate smartphone messaging interventions on remote transmission of blood pressure (BP) and heart rate (HR) data.

Methods
We conducted a 2 × 2 × 2 factorial blinded randomized trial with randomization implemented centrally to ensure allocation concealment. We invited participants from the Electronic Framingham Heart Study (eFHS), an e-cohort embedded in the FHS, and asked participants to measure their BP (Withings digital cuff) weekly and wear their smartwatch daily. We assessed 3 weekly notification strategies to promote adherence: personalized versus standard; weekend versus weekday; and morning versus evening. Personalized notifications included the participant’s name and were tailored to whether or not data from the prior week were transmitted to the research team. Intervention notification messages were delivered weekly automatically via the eFHS app. We assessed if participants transmitted at least one BP or HR measurement within 7 days of each notification after randomization. Outcomes were adherence to BP and HR transmission at 3 months (primary) and 6 months (secondary).

Results
Of the 791 FHS participants, 655 (82.8%) were eligible and randomized (mean age 53, SD 9 years; 392/655, 59.8% women; 596/655, 91% White). For the personalized versus standard notifications, 38.9% (126/324) versus 28.8% (94/327) participants sent BP data at 3 months (difference=10.1%, 95% CI 2.9%-17.4%; P=.006), but no significant differences were observed for HR data transmission (212/324, 65.4% vs 209/327, 63.9%; P=.69). Personalized notifications were associated with increased BP and HR data transmission versus standard at 6 months (BP: 107/291, 36.8% vs 66/295, 22.4%; difference=14.4%, 95% CI 7.1- 21.7%; P<.001; HR: 186/281, 66.2% vs 158/281, 56.2%; difference=10%, 95% CI 2%-18%; P=.02). For BP and HR primary or secondary outcomes, there was no evidence of differences in data transmission for notifications sent on weekend versus weekday or morning versus evening.

Conclusions
Personalized notifications increased longitudinal adherence to BP and HR transmission from mobile and digital devices among eFHS participants. Our results suggest that personalized messaging is a powerful tool to promote adherence to mobile health systems in cardiovascular research.

Trial Registration
ClinicalTrials.gov NCT03516019; https://clinicaltrials.gov/ct2/show/NCT03516019
Editorial
Authors: Izquierdo Barrera Martha Lucía 
Published: January 2023

Nos complace presentar a nuestros lectores y público en general el primer número del volumen 17 de la Revista Miradas - 2022 de la Facultad de Ciencias de la Educación de la Universidad Tecnológica de Pereira.
En esta edición continuamos trabajando en el posicionamiento de la revista tanto en el ámbito local, nacional e internacional.
Este número de 2022 trae cinco artículos que muestran resultados de investigación, revisión y reflexión alrededor de categorías como la educación, la comunicación y la cultura a través de temas como las políticas públicas como las TIC y la formación universitaria, Covid-19, prácticas pedagógicas, primera infancia, empleo, pronombres, derecho penal y lavado de dinero.
La lectura inicia con el primer trabajo titulado “Las TIC en la formación universitaria durante la pandemia COVID-19: Perspectivas de estudiantes de Comunicación en el Perú”, es un trabajo resultado de investigación en el cual se habla de la implementación de las TIC en los procesos de formación virtual a causa de la pandemía por Covid-19 en Perú.
El segundo artículo titulado “Resignificación de las prácticas pedagógicas: la reflexión docente y su implicación con la primera infancia” es un trabajo resultado de investigación donde se asume el análisis, resignificación y reflexión generada desde la práctica pedagógica docente al proceso de enseñanza y aprendizaje de niños y niñas de primera infancia según las políticas públicas de educación emitidas por el Ministerio de Educación Nacional MEN para el territorio colombiano.
Continuando con este ejercicio de presentación, el tercer artículo titulado “Precarización de las condiciones del empleo en Ciudad Juárez, Chihuahua, México 2021” y hace aprte de los resultados de investigación El objetivo central fue el caracterizar las condiciones laborales de la población ocupada en Ciudad Juárez, Chihuahua, México a través de la creación de un Índice de Precariedad del Empleo (IPE) que represente de manera resumida la precarización del empleo por sexo y grupo de edad.
Así mismo, el cuarto artículo titulado “El uso de los pronombres de tratamiento tú, usted y vos en el departamento del Quindío”, hace parte de los resultado de una investigaciónesta titulada “Tratamiento pronominal en el Quindío”, el objetivo principal de esta investigación fue analizar el uso de los pronombres de tratamiento en este departamento a través de encuestas a personas cuyas edades oscilaron entre los 12 y 70 años.
En este punto, se da un giro temático, el quinto artículo titulado “Derecho penal del enemigo para combatir el delito de lavado de dinero en México” que es resultado de investigación del fenómeno delictivo del lavado de dinero en México, se sanciona conforme a ordenamientos jurídicos tanto internacionales como nacionales.

Esperamos que esta publicación sea del agrado de nuestros lectores.
Dra. Martha Lucía Izquierdo Barrera
Directora Revista miradas
Relación entre supervisión o monitoreo, empatía y comportamiento agresivo en adolescentes escolarizados de Bogotá
Authors: Guevara Marín Ivon Paola , Arango Diago Tatiana , Monroy Cano Katherine Paola 
Published: January 2023

El propósito de esta investigación consistió en analizar la relación entre la supervisión o monitoreo, la empatía y el comportamiento agresivo –verbal y físico– en adolescentes escolarizados de Bogotá. El estudio es de tipo descriptivo-correlacional de corte trasversal.
La muestra estuvo conformada por 324 adolescentes escolarizados en la ciudad de Bogotá, con edades comprendidas entre los 11 a 18 años: 158 adolescentes de sexo femenino (48,76 %) y 166 de sexo masculino (51,24 %).
Los resultados mostraron que la divulgación o comunicación espontánea de las actividades de los adolescentes hacia la madre se relaciona de manera inversa con el comportamiento agresivo, específicamente la agresión física en adolescentes de sexo masculino. Así mismo, se encontró que la empatía es la variable predictora con mayor peso en la aparición de la agresión física en adolescentes de sexo masculino; mientras que las variables independientes: comunicación abierta de papá, control parental de papá y empatía logran explicar el 24,6 % de la variabilidad de la agresión verbal en adolescentes mujeres.
Loss of Hematopoietic Cell–Derived Oncostatin M Worsens Diet-Induced Dysmetabolism in Mice
Authors: Albiero Mattia , Ciciliot Stefano , Rodella Anna , Migliozzi Ludovica , Amendolagine Francesco Ivan , Boscaro Carlotta , Zuccolotto Gaia , Rosato Antonio , Fadini Gian Paolo 
Published: January 2023

Innate immune cells infiltrate growing adipose tissue and propagate inflammatory clues to metabolically distant tissues, thereby promoting glucose intolerance and insulin resistance. Cytokines of the IL-6 family and gp130 ligands are among such signals. The role played by oncostatin M (OSM) in the metabolic consequences of overfeeding is debated, at least in part, because prior studies did not distinguish OSM sources and dynamics. Here, we explored the role of OSM in metabolic responses and used bone marrow transplantation to test the hypothesis that hematopoietic cells are major contributors to the metabolic effects of OSM. We show that OSM is required to adapt during the development of obesity because OSM concentrations are dynamically modulated during high-fat diet (HFD) and Osm−/− mice displayed early-onset glucose intolerance, impaired muscle glucose uptake, and worsened liver inflammation and damage. We found that OSM is mostly produced by blood cells and deletion of OSM in hematopoietic cells phenocopied glucose intolerance of whole-body Osm−/− mice fed a HFD and recapitulated liver damage with increased aminotransferase levels. We thus uncovered that modulation of OSM is involved in the metabolic response to overfeeding and that hematopoietic cell–derived OSM can regulate metabolism, likely via multiple effects in different tissues.ARTICLE HIGHLIGHTS
Inflammatory Cell Infiltration Into Islets Without PD-L1 Expression Is Associated With the Development of Immune Checkpoint Inhibitor–Related Type 1 Diabetes in Genetically Susceptible Patients
Authors: Kawata Satoshi , Kozawa Junji , Yoneda Sho , Fujita Yukari , Kashiwagi-Takayama Risa , Kimura Takekazu , Hosokawa Yoshiya , Baden Megu Y. , Uno Sae , Uenaka Rikako , Namai Kazuyuki , Koh Yoko , Tomimaru Yoshito , Hirata Haruhiko , Uemura Motohide , Nojima Satoshi , Morii Eiichi , Eguchi Hidetoshi , Imagawa Akihisa , Shimomura Iichiro 
Published: January 2023

Immune checkpoint inhibitors (ICIs) could cause type 1 diabetes (T1D). However, the underlying mechanism remains unclear. We immunohistochemically analyzed pancreatic specimens from three individuals with ICI-related T1D, and their histopathological data were compared those from three patients who had received ICI therapy but did not develop T1D (non-T1D) and seven normal glucose-tolerant subjects as control subjects. All ICI-related T1D patients had susceptible HLA haplotypes. In ICI-related T1D, the β-cell area decreased and the α-cell area increased compared with non-T1D and control subjects. The number of CD3-positive cells around islets increased in ICI-related T1D and non-T1D compared with control subjects, while the number of CD68-positive cells around islets increased in ICI-related T1D compared with non-T1D and control subjects. The expression ratios of programmed death-ligand 1 (PD-L1) on islets decreased in non-T1D and almost completely disappeared in ICI-related T1D, while PD-L1 expression was observed in most cells of pancreatic islets in control subjects. This study, therefore, indicates that ICI therapy itself could reduce PD-L1 expression on islets in all subjects, which may be related to β-cell vulnerability. In addition, we showed that absence of PD-L1 expression on β-cells, genetic susceptibility, and infiltration of macrophages as well as T lymphocytes around islets might be responsible for T1D onset.ARTICLE HIGHLIGHTS
Predictive Value of C-Peptide Measures for Clinical Outcomes of β-Cell Replacement Therapy in Type 1 Diabetes: Report From the Collaborative Islet Transplant Registry (CITR)
Authors: Baidal David A. , Ballou Cassandra M. , Rickels Michael R. , Berney Thierry , Pattou Francois , Payne Elizabeth H. , Barton Franca B. , Alejandro Rodolfo ,   CITR Investigators
Published: January 2023

OBJECTIVETo determine C-peptide measures and levels associated with positive glycemic control outcomes following islet transplant (ITx) in type 1 diabetes.RESEARCH DESIGN AND METHODSWe evaluated Collaborative Islet Transplant Registry (CITR) islet-alone recipients with pretransplant C-peptide &lt;0.1 nmol/L and mean follow-up of 4.6 ± 1.1 years (n = 677). Receiver operating characteristic area under the curve (ROC-AUC) was used to evaluate the predictive value of fasting and stimulated glucose and C-peptide measures for seven primary outcomes: 1) absence of severe hypoglycemic events (ASHEs); 2) HbA1c &lt;7.0%; 3) HbA1c &lt;7.0% and ASHEs; 4) HbA1c ≤6.5%; 5) HbA1c ≤6.5% and ASHEs; 6) insulin independence; and 7) ASHEs, HbA1c ≤6.5%, and insulin independence (the optimal outcome). Measures with the highest ROC-AUC were selected for determination of optimal cut points.RESULTSFasting C-peptide was highly predictive for ASHE (ROC-AUC 0.906; optimal cut point 0.070 nmol/L) and the optimal outcome (ROC-AUC 0.845; optimal cut point 0.33 nmol/L). Mixed-meal tolerance test (MMTT)–stimulated C-peptide-to-glucose ratio (CPGR) outperformed both fasting and stimulated C-peptide for all outcomes except ASHE. The optimal cut point for the optimal outcome was 0.12 nmol/mmol for MMTT-stimulated CPGR and 0.97 nmol/L for MMTT-stimulated C-peptide.CONCLUSIONSFasting C-peptide reliably predicts ITx primary outcomes. MMTT-stimulated CPGR provides marginally better prediction for composite ITx outcomes, including insulin independence. In the absence of an MMTT, a fasting C-peptide ≥0.33 nmol/L is a reassuring measure of optimal islet graft function. C-peptide targets represent excellent and easily determinable means to predict glycemic control outcomes after ITx and should be considered as potential goals of β-cell replacement.
Optimization of Albuminuria-Lowering Treatment in Diabetes by Crossover Rotation to Four Different Drug Classes: A Randomized Crossover Trial
Authors: Curovic Viktor Rotbain , Jongs Niels , Kroonen Marjolein Y.A.M. , Zobel Emilie H. , Hansen Tine W. , Sen Taha , Laverman Gozewijn D. , Kooy Adriaan , Persson Frederik , Rossing Peter , Heerspink Hiddo J.L. 
Published: January 2023

OBJECTIVERenin–angiotensin system (RAS) inhibitors decrease the urinary albumin to creatinine ratio (UACR) but are ineffective in up to 40% of patients. We hypothesized that rotation through different drug classes overcomes RAS inhibitor resistance and tested this in a randomized crossover trial.RESEARCH DESIGN AND METHODSWe assigned 26 adults with type 1 diabetes and 37 with type 2 diabetes and UACR between 30 and 500 mg/g and estimated glomerular filtration rate &gt;45 mL/min/1.73 m2 to 4-week treatment periods with telmisartan 80 mg, empagliflozin 10 mg, linagliptin 5 mg, and baricitinib 2 mg in random order, separated by 4-week washout periods. Each participant was then re-exposed for 4 weeks to the drug that induced that individual’s largest UACR reduction. Primary outcome was the difference in UACR response to the best-performing drug during the confirmation period versus UACR response to the other three drugs.RESULTSThere was substantial variation in the best-performing drug. Telmisartan was best performing for 33 participants (52%), empagliflozin and linagliptin in 11 (17%), and baricitinib in 8 participants (13%). The individuals’ best-performing drug changed UACR from baseline during the first and confirmatory exposures by a mean of −39.6% (95% CI −44.8, −33.8; P &lt; 0.001) and −22.4% (95% CI −29.7, −12.5; P &lt; 0.001), respectively. The Pearson correlation for first versus confirmatory exposure was 0.39 (P = 0.017). The mean change in UACR with the other three drugs was +1.6% (95% CI −4.3%, 8.0%; P = 0.593 versus baseline; difference versus individuals’ best-performing drug at confirmation, 30.9% [95% CI 18.0, 45.3]; P &lt; 0.001).CONCLUSIONSWe demonstrated a large and reproducible variation in participants’ responses to different UACR-lowering drug classes. These data support systematic rotation through different drug classes to overcome therapy resistance to RAS inhibition.
O Ensino de Geometria Plana na perspectiva do Programa Etnomatemática em uma escola quilombola: possibilidades e desafios
Authors: Santos Hélio Rodrigues dos , Lima Paulo Vinícius Pereira de , Moreira Geraldo Eustáquio 
Published: January 2023

O estudo tem como objetivo geral apresentar os resultados de atividades de ensino e aprendizagem em geometria plana, na perspectiva do Programa Etnomatemática, realizadas em uma escola quilombola. Especificamente, buscamos refletir sobre o ensino de geometria plana na perspectiva da Etnomatemática; realizar atividades pedagógicas de geometria na perspectiva do Programa e identificar as contribuições das atividades pedagógicas aplicadas, aliadas à realidade quilombola. A atividade foi desenvolvida em três momentos: inicialmente, com conceitos (leitura, identificação e compreensão de figuras planas); posteriormente foi a observação (imagens na natureza, em casa e em outros espaços) e o terceiro momento foi de interação pedagógica (confecções, discussões e classificações das figuras planas). A atividade foi realizada na comunidade quilombola Kalunga Ema, com alunos dos 5° e 6° anos do Ensino Fundamental. O estudo é de abordagem qualitativa e para a coleta de dados utilizamos a observação participante e a análise descritiva. Após a identificação e conceituação, foi realizada a construção de materiais didáticos com os estudantes. Evidenciou-se que muitos estudantes tinham dificuldades em identificar e conceituar itens elementares da geometria plana, bem como resolver questões, ainda que simples e/ou aliadas ao próprio cotidiano. Após a atividade com a proposta realizada e a avaliação oral, constatou-se que a maioria dos estudantes conseguiu identificar e compreender conceitos da geometria plana; as atividades realizadas geraram maior interação e contribuiu na relação professor-estudante; o desenvolvimento de novas metodologias contribui significativamente na formação continuada de professores que ensinam Matemática; a construção de materiais didáticos com o protagonismo dos estudantes revelou-se significativa, e por final, o conjunto de atividades possibilitou os estudantes a relacionarem a geometria plana ao cotidiano quilombola e aplicar em pequenas atividades da comunidade, tais como hortas, currais e nas relações de trabalho, evidenciando o êxito esperado.
Profession : sémioticiens. I. Options et perspectives en 2022
Authors: Demuru Paolo , Sedda Franciscu , Landowski Eric 
Published: January 2023

Au cours de l’automne 2022, les trois sémioticiens susnommés, proches en esprit bien que le plus souvent éloignés dans l’espace, ont entrepris de formuler à l’attention des lecteurs d’</em>Acta Semiotica<em>, sous la forme d’une conversation par e-mail, quelques-unes de leurs options relatives à l’esprit dans lequels ils mènent leur recherche et leur enseignement. Le tour d’horizon qui suit constitue la première partie de ce dialogue. La seconde, consacrée plus spécialement aux apports à attendre d’autres courants sémiotiques ou d’autres disciplines, sera publiée dans le prochain numéro.
Les trois intervenants ont l’habitude de s’écrire chacun dans sa propre langue. Depuis toujours, c’est l’usage entre sémioticiens. Cette diversité a été respectée dans ce qui suit, considérant qu’on peut difficilement être linguiste ou sémioticien sans lire indifféremment les cinq principales langues utilisées dans cette revue parce qu’elles font partie de celles dans lesquelles notre discipline s’est construite et se développe aujourd’hui.
A review of horses sent to slaughter for human consumption: impact of horsemeat consumption, residual banned drugs, and public health risks
Authors: Weber Klaus , Kearley Michael E. , Marini Ann M. , Pressman Peter , Hayes A. Wallace 
Published: January 2023

ABSTRACT
Nearly all of the American horses exported to Mexico and Canada are slaughtered for human consumption, and their meat is either exported around the world or consumed locally. Previous work showed that 18 Thoroughbred racehorses purchased by rescues that would have otherwise been sold for export for the sole purpose of slaughter to produce meat for human consumption were administered phenylbutazone. We report the number of American horses exported to Canada and Mexico from 2016 to 2021, the presence of contaminated horsemeat from Canadian slaughterhouses, and the human use and idiosyncratic effects of veterinary phenylbutazone and side effects of clenbuterol, 2 of the drugs that were found in contaminated Canadian horsemeat. The number of live American horses exported to Canada declined precipitously from 2016 to 2017, and a second decline occurred in 2020. All food-producing animals are under strict regulatory control to prevent animals administered banned drugs to enter the food chain. A major principle of this program is zero tolerance for banned drugs and testing for compliance. No regulatory process is in place to remove horses administered banned drugs such as phenylbutazone. The efficacy lasts for more than 24 hours as a result of the irreversible binding to cyclooxygenase, slow elimination, and long elimination half-life of its metabolite oxyphenbutazone. High or frequent doses of phenylbutazone result in disproportionately increased plasma concentrations, which result in the residual presence in tissues. It is this fact that underlies the ban of this drug in food-producing animals. No human clinical surveillance program is in place to monitor individuals on the possible short- and long-term consequences of banned drugs in contaminated horsemeat. If the United States is unable to put in place a regulatory program to remove horses administered banned drugs as exists for all food-producing animals, the exportation of American horses across both borders for the sole purpose of slaughter for human consumption must end.