bluuebunny/crossref_metadata_2025_split huggingface dataset:
A simulation of the impacts of machine learning to combine psychometric employee selection system predictors on performance prediction, adverse impact, and number of dropped predictors
Authors: Landers Richard N. , Auer Elena M. , Dunk Lily , Langer Markus , Tran Khue N. 
Published: March 2023

AbstractWe compare modern machine learning (MML) techniques to ordinary least squares (OLS) regression on out‐of‐sample (OOS) operational validity, adverse impact, and dropped predictor counts within a common selection scenario: the prediction of job performance from a battery of diverse psychometrically‐validated tests. In total, scores from 1.2 billion validation study participants were simulated to describe outcomes across 31,752 combinations selection system design and scoring decisions. The most consistently valuable improvement from adopting MML over traditional regression was from dropping predictors rather than by improving prediction. On average, MML improved prediction of performance from psychometric scale composites only when the ratio of sample size to scale count was less than approximately 3, although algorithm choice, predictor count, and selection ratio affected outcomes as well. We also simulated the effects of design choices when combining item scores, which showed consistent, superior predictive accuracy for several MML algorithms, especially elastic net and random forest, over traditional regression. Given these results, we suggest the potential of machine learning for employee selection is unlikely to be realized in selection systems focusing on the combination of scale composites from previously validated psychometric tests. Instead, it will be realized in unconventional design scenarios, such as the use of individual items to make multiple trait inferences, or with novel data formats like text, image, audio, video, and behavioral traces. We therefore recommend researchers focus on the potential value of MML in future selection contexts rather than continuing to focus on the current value of MML in current selection contexts.
Design paths of federal intergovernmental cooperation
Authors: Montfort Simon , Fischer Manuel , Hollway James , Jager Nicolas W. 
Published: March 2023

AbstractActors rarely approach institutional design choices with a blank slate but are influenced by design choices made at earlier stages. How does institutional design evolve over time and are there specific paths to deepening cooperation? We investigate the institutional design paths of subnational cooperation that are chosen to address increasingly complex and interconnected policy problems. We theorize that besides the substantive problem, earlier choices matter to explain what institutional design mechanism is chosen; that is, the design of existing institutions between two subnational governance units, called substates, influences the design of subsequent institutions. Using a semi‐parametric Cox proportional hazards model, we show that the design paths of subnational cooperation in the Swiss water governance sector correlate with earlier design choices. Our results indicate that not all cooperation is self‐reinforcing and path‐dependent, but they show which specific design choices are more likely to follow each other in repeated formal federal intergovernmental cooperation.
Full‐length EFOP3 and EFOP4 proteins are essential for pollen intine development in Arabidopsis thaliana
Authors: Chen Xinlong , Zhang Yingying , Yin Wuzhong , Wei Gang , Xu Hailing , Ma Lu , Tian Weijiang , Yang Guang , Li Yunfeng , Wu Renhong , Zhang Ting , Wang Nan , He Guanghua 
Published: March 2023

SUMMARYPollen development is critical to plant reproduction, but the underlying regulatory molecular mechanisms have not been fully elucidated. The Arabidopsis (Arabidopsis thaliana) EFR3 OF PLANT 3 (EFOP3) and EFR3 OF PLANT 4 (EFOP4) genes encode members of the Armadillo (ARM) repeat superfamily that play key roles in pollen development. Herein, we demonstrate that EFOP3 and EFOP4 are co‐expressed in pollen at anther stages 10–12, but loss‐of‐function of both EFOP3 and EFOP4 leads to male gametophyte sterility, irregular intine, and shriveled pollen grains at anther stage 12. We further established that full‐length EFOP3 and EFOP4 specifically localize to the plasma membrane, and the integrity of these proteins is essential for pollen development. We observed uneven intine, less organized cellulose and reduced pectin content in mutant pollen compared with the wild‐type. These, together with the misexpression of several genes related to cell wall metabolism in efop3−/− efop4+/− mutants, suggest that EFOP3 and EFOP4 may indirectly regulate the expression of these genes to affect intine formation, thus controlling Arabidopsis pollen fertility in a functionally redundant manner. Moreover, transcriptome analysis showed that the absence of EFOP3 and EFOP4 function affects multiple pollen development pathways. These results enhance our understanding of EFOPs proteins and their role in pollen development.
Imaging features of benign synovial inflammation affecting the long digital extensor tendon sheath in a dog
Authors: Scharf Alexandra , Husbands Brian D. , Tremolada Giovanni , Hostnik Eric T. 
Published: March 2023

AbstractA dog was evaluated for right pelvic limb lameness. Computed tomography and magnetic resonance imaging revealed an irregular, contrast‐enhancing mass extending along the proximolateral right tibia, involving the long digital extensor tendon (LDET) ± cranial tibialis muscle. Pulmonary nodules, nonspecific hepatomegaly, and splenic nodules were also present. The primary differential diagnosis was soft tissue neoplasia. Surgical biopsy with histopathology revealed benign, chronic inflammation, and fibrosis. Idiopathic synovial inflammation should be included as a differential diagnosis for dogs with this combination of clinical and imaging characteristics.
Seed germination of common and endangered arable weed species is differently affected by the herbicide metazachlor and its transformation products
Authors: García Andrés , Eichberg Carsten , Wendell Anne‐Kathrin , Pfeifer Simon , Ludewig Kristin , Donath Tobias W. , Ulrich Uta 
Published: March 2023

AbstractHigh inputs of herbicides have caused the decline of arable weed species, which formerly evolved under less intensively managed crop lands. Arable weed species have adapted their germination strategies to respond to unfavourable periods. However, species considered endangered have more specific germination requirements. The herbicide metazachlor (MZ), in its formulated form Butisan®, is used for the control of annual and dicotyledonous weeds and degrades in the soil into two major transformation products (TPs): metazachlor oxalic acid (MZ‐OA) and metazachlor ethane sulphonic acid (MZ‐ESA). These TPs are often found in higher concentrations compared to MZ. We tested the effect of MZ and its TP on seed germination of four common and three endangered arable weed species present in Central Europe by setting up multi‐factorial climate chamber experimental designs. We chose concentrations imitating field conditions and according to previously reported fraction occurrences in the topsoil. We assessed germination by measuring germination percentage, mean germination time and synchrony of germination. All germination variables were affected with increasing concentrations of MZ. Both, common and endangered species showed a decrease in germination percentage under the highest concentration of MZ. MZ and MZ‐OA increased the synchronicity of endangered species, while both TPs decreased mean germination time of endangered species. Common species showed less significant differences when compared to the control and also had a less synchronised and longer germination time compared to endangered species. The observed response of common species to both MZ and TPs may be convenient in the face of short term unfavourable environmental conditions, such as those found in intensively managed arable lands. Our results highlight that the species‐specific response of arable weeds to herbicides will further increase the dominance of common over rare arable weed species.
Comparison of carotid endarterectomy and repeated carotid angioplasty and stenting for in-stent restenosis (CERCAS trial): a randomised study
Authors: Hrbáč Tomáš , Fiedler Jiří , Procházka Václav , Jonszta Tomáš , Roubec Martin , Pakizer David , Václavík Daniel , Netuka David , Heryán Tomáš , Školoudík David 
Published: March 2023

Background and aimIn-stent restenosis (ISR) belongs to an infrequent but potentially serious complication after carotid angioplasty and stenting in patients with severe carotid stenosis. Some of these patients might be contraindicated to repeat percutaneous transluminal angioplasty with or without stenting (rePTA/S). The purpose of the study is to compare the safety and effectiveness of carotid endarterectomy with stent removal (CEASR) and rePTA/S in patients with carotid ISR.MethodsConsecutive patients with carotid ISR (≥80%) were randomly allocated to the CEASR or rePTA/S group. The incidence of restenosis after intervention, stroke, transient ischaemic attack myocardial infarction and death 30 days and 1 year after intervention and restenosis 1 year after intervention between patients in CEASR and rePTA/S groups were statistically evaluated.ResultsA total of 31 patients were included in the study; 14 patients (9 males; mean age 66.3±6.6 years) were allocated to CEASR and 17 patients (10 males; mean age 68.8±5.6 years) to the rePTA/S group. The implanted stent in carotid restenosis was successfully removed in all patients in the CEASR group. No clinical vascular event was recorded periproceduraly, 30 days and 1 year after intervention in both groups. Only one patient in the CEASR group had asymptomatic occlusion of the intervened carotid artery within 30 days and one patient died in the rePTA/S group within 1 year after intervention. Restenosis after intervention was significantly greater in the rePTA/S group (mean 20.9%) than in the CEASR group (mean 0%, p=0.04), but all stenoses were <50%. Incidence of 1-year restenosis that was ≥70% did not differ between the rePTA/S and CEASR groups (4 vs 1 patient; p=0.233).ConclusionCEASR seems to be effective and save procedures for patients with carotid ISR and might be considered as a treatment option.Trial registration numberNCT05390983.
Indirect dark-matter detection with MadDM v3.2 – Lines and Loops
Authors: Arina Chiara , Heisig Jan , Maltoni Fabio , Massaro Daniele , Mattelaer Olivier 
Published: March 2023

AbstractAutomated tools for the computation of particle physics’ processes have become the backbone of phenomenological studies beyond the standard model. Here, we present MadDM v3.2. This release enables the fully automated computation of loop-induced dark-matter annihilation processes, relevant for indirect detection observables. Special emphasis lies on the annihilation into $$\gamma X$$

γ
X

, where $$X=\gamma , Z, h$$

X
=
γ
,
Z
,
h

or any new particle even under the dark symmetry. These processes lead to the sharp spectral feature of monochromatic gamma lines – a smoking-gun signature of dark matter in our Galaxy. MadDM provides the predictions for the respective fluxes near-Earth and derives constraints from the gamma-ray line searches by Fermi-LAT and HESS. As an application, we discuss the implications for the viable parameter space of a top-philic t-channel mediator model and the inert doublet model.
Large B-cell Lymphomas of Immune-Privileged Sites Relapse via Parallel Clonal Evolution from a Common Progenitor B Cell
Authors: Los-de Vries G. Tjitske , Stathi Phylicia , Rutkens Ryanne , Hijmering Nathalie J. , Luijks Jeroen A.C.W. , Groenen Patricia J.T.A. , de Jong Daphne , Ylstra Bauke , Roemer Margaretha G.M. 
Published: March 2023

Abstract

Large B-cell lymphoma of immune-privileged sites (LBCL-IP) arise in immune sanctuaries including the testis and central nervous system (CNS). After initially reaching complete response, relapses occur in almost 50% of patients, typically at other immune-privileged sites. Resolution of the clonal relationships and evolutionary patterns of LBCL-IP is required to understand the unique clinical behavior. We collected a unique set of 33 primary–relapse LBCL-IP sample pairs and performed next-generation sequencing for copy number, mutation, translocation, and immunoglobulin clonality analysis. All LBCL-IP sample pairs were clonally related, and both tumors developed from a common progenitor cell (CPC) with MYD88 and TBL1XR1 mutations and/or BCL6 translocations in 30/33 cases, indicating that these are early genetic events. This was succeeded by intermediate genetic events including shared, as well as unique alterations in targets of aberrant somatic hypermutation (aSHM), CD79B mutations, and 9p21.3/CDKN2A loss. Genetic alterations in genes involved in immune escape (HLA, CD274/PDCD1LG2) were predominantly unique in primary and relapse samples and thus considered late genetic events. Together, this study indicates that primary and relapsed LBCL-IP follow an early parallel evolutionary pattern where the CPC contains genetic alterations that support prolonged survival/proliferation and retention in a memory B-cell state, followed by germinal center reentry, aSHM and immune escape.

Significance:
Genomic analyses reveal that primary and relapse LBCL-IP originate from a common progenitor cell with a small set of genetic alterations, followed by extensive parallel diversification, elucidating the clonal evolution of LBCL-IP.
Terminally Exhausted CD8+ T Cells Resistant to PD-1 Blockade Promote Generation and Maintenance of Aggressive Cancer Stem Cells
Authors: Chakravarti Mohona , Dhar Sukanya , Bera Saurav , Sinha Abhipsa , Roy Kamalika , Sarkar Anirban , Dasgupta Shayani , Bhuniya Avishek , Saha Akata , Das Juhina , Banerjee Saptak , Vernekar Manisha , Pal Chiranjib , Alam Neyaz , Datta Dipak , Baral Rathindranath , Bose Anamika 
Published: March 2023

AbstractHeterogeneity within the tumor-infiltrating lymphocytes (TIL) population limits immunotherapeutic efficacy against cancer. Between two subpopulations of exhausted CD8+ TILs (progenitor-exhausted; TPEX, terminally exhausted; TTEX), TTEX cells remain unresponsive to anti–programmed cell death protein 1(PD-1) therapy. Deciphering whether and how PD-1–resistant TTEX cells engage in tumor promotion could improve the response to immunotherapy. Here, we report that TTEX cells actively participate in tumor progression by modulating cancer stem cells (CSC). TTEX cells strongly correlated with elevated CSC frequency in poorly immune-infiltrated (CD8+ TIL low) advanced human breast and ovarian carcinomas. TTEX directly upregulated CSC frequency in vitro, which was not affected by anti–PD-1 treatment. The TTEX-influenced CSCs were highly clonogenic and exhibited a multidrug-resistant phenotype, overexpressing drug efflux pumps like ABCC1 and ABCB1. These CSCs were highly invasive, displaying increased invadopodia development and elevated cofilin, CXCR4, and matrix metalloproteinase 7 (MMP7) expression. The invasive properties along with epithelial–mesenchymal plasticity of TTEX-educated CSCs increased metastasis in vivo. TTEX increased cell surface levels and activation of VEGFR2 in CSCs, and silencing or inhibition of VEGFR2 reversed the CSC-stimulatory effects of TTEX. LAMP3 and NRP1 on the surface of TTEX stimulated VEGFR2 in CSCs to promote aggressiveness. Cumulatively, these findings suggest that screening patients with carcinoma for both CD8+ TILs and TTEX frequency prior to anti–PD-1 therapy could improve patient outcomes. In addition, targeting the LAMP3/NRP1–VEGFR2 axis could be a therapeutic strategy in advanced patients with carcinoma with limited CD8+ T-cell infiltration and high TTEX frequency.Significance:Cross-talk with TTEX CD8+ T cells mediated by the VEGFR2 axis induces aggressive properties in cancer stem cells to promote tumor progression.
A Phase II Study of Epacadostat and Pembrolizumab in Patients with Advanced Sarcoma
Authors: Kelly Ciara M. , Qin Li-Xuan , Whiting Karissa A. , Richards Allison L. , Avutu Viswatej , Chan Jason E. , Chi Ping , Dickson Mark A. , Gounder Mrinal M. , Keohan Mary Louise , Movva Sujana , Nacev Benjamin A. , Rosenbaum Evan , Adamson Travis , Singer Samuel , Bartlett Edmund K. , Crago Aimee M. , Yoon Sam S. , Hwang Sinchun , Erinjeri Joseph P. , Antonescu Cristina R. , Tap William D. , D'Angelo Sandra P. 
Published: March 2023

Abstract

Purpose:
Epacadostat, an indole 2,3 dioxygenase 1 (IDO1) inhibitor, proposed to shift the tumor microenvironment toward an immune-stimulated state, showed early promise in melanoma but has not been studied in sarcoma. This study combined epacadostat with pembrolizumab, which has modest activity in select sarcoma subtypes.

Patients and Methods:
This phase II study enrolled patients with advanced sarcoma into five cohorts including (i) undifferentiated pleomorphic sarcoma (UPS)/myxofibrosarcoma, (ii) liposarcoma (LPS), (iii) leiomyosarcoma (LMS), (iv) vascular sarcoma, including angiosarcoma and epithelioid hemangioendothelioma (EHE), and (v) other subtypes. Patients received epacadostat 100 mg twice daily plus pembrolizumab at 200 mg/dose every 3 weeks. The primary endpoint was best objective response rate (ORR), defined as complete response (CR) and partial response (PR), at 24 weeks by RECIST v.1.1.

Results:
Thirty patients were enrolled [60% male; median age 54 years (range, 24–78)]. The best ORR at 24 weeks was 3.3% [PR, n = 1 (leiomyosarcoma); two-sided 95% CI, 0.1%–17.2%]. The median PFS was 7.6 weeks (two-sided 95% CI, 6.9–26.7). Treatment was well tolerated. Grade 3 treatment-related adverse events occurred in 23% (n = 7) of patients. In paired pre- and post-treatment tumor samples, no association was found between treatment and PD-L1 or IDO1 tumor expression or IDO-pathway–related gene expression by RNA sequencing. No significant changes in serum tryptophan or kynurenine levels were observed after baseline.

Conclusions:
Combination epacadostat and pembrolizumab was well tolerated and showed limited antitumor activity in sarcoma. Correlative analyses suggested that inadequate IDO1 inhibition was achieved.
Simulation and optimization of hydrogen consumption in a fuel cell/battery hybrid vehicle
Authors: Touileb Rachid , Abbou Ahmed 
Published: March 2023

This paper presents a physics-based mathematical model for a fuel cell hybrid vehicle system. The performance design of fuel cell hybrid electric vehicles (FCHEVs) is an area of interest in transportation applications. FCHEV is a combination of a proton exchange membrane fuel cell (PEMFC), with a battery and associated DC/DC and DC/AC converters. Suitable batteries are used in FCHEV acts as a backup system with efficient energy management. The battery is designed for fast power transfer during transient response and constant performance without hydrogen. The power management schemes discussed are consistent with the most common modern power management techniques used in fuel cell vehicle applications, including: the state engine control strategies, rule-based fuzzy logic strategies, classical proportional integral control strategies, frequency fuzzy logic decoupling/control minimization strategies. Therefore, we tested and evaluated the reliability of the model using the MATLAB/Simulink environment, with mixed results.
Quando as Marias falam: assessorias de imprensa no debate sobre a violência contra mulheres em Mato Grosso do Sul
Authors: Panziera Tathiane Espíndola , Miguel Katarini Giroldo 
Published: March 2023

Nossa pesquisa analisa a influência das assessorias de imprensa de órgãos voltados às políticas públicas para mulheres em Mato Grosso do Sul no debate sobre violência de gênero. Cruzamos os materiais divulgados pelas assessorias entre março e novembro de 2019 com as publicações dos principais jornais do estado para entender o quanto e como esses temas eram abordados. A partir do clipping e da auditoria de imagem, debatemos o espaço explorado e trazemos sugestões que ampliariam a participação das “Marias” na cobertura midiática.
Poststroke Intravenous Transplantation of Human Mesenchymal Stem Cells Improves Brain Repair Dynamics and Functional Outcomes in Aged Mice
Authors: Zhang Wenting , Pu Hongjian , Hu Xiaoming , Shi Yejie , Leak Rehana K. , Anne Stetler R. , Ye Qing , Lyu Junxuan , Zhang Feng , Wechsler Lawrence R. , Chen Jun 
Published: March 2023

Background:
Stroke is the primary cause of chronic disability in the elderly, as there are no neurorestorative treatments for those who do not qualify for recanalization therapy. Experimental evidence in stroke animals suggests that transplantation of bone marrow–derived human mesenchymal stem cells (hMSCs) holds promise, but hMSC transplantation has not been systematically tested in aged animals. We tested the hypothesis that poststroke hMSC transplantation improves stroke recovery in aged mice by promoting brain repair.

Methods:

Permanent focal cerebral ischemia was induced in 20-month-old C57BL/6 male mice by distal middle cerebral artery occlusion. Bone marrow–derived hMSCs were expanded in vitro and then administrated intravenously into mice (1×10
6
cells in PBS) 24 hours after distal middle cerebral artery occlusion. Sensorimotor and cognitive functions, brain atrophy, and brain repair processes (neurogenesis, angiogenesis, oligodendrogenesis) were assessed for up to 56 days after stroke.

Results:
Poststroke hMSC transplantation did not mitigate brain atrophy or improve neuronal survival at 56 days after distal middle cerebral artery occlusion. However, hMSC-treated mice displayed superior neurobehavioral performances in the open field, rotarod, adhesive removal, novel object, and Morris water maze tests compared with PBS-treated controls. hMSCs promoted white matter integrity and enhanced angiogenesis and oligodendrogenesis—but not neurogenesis—in the stroke brain. Positive correlations between neurobehavioral performance and brain repair profiles or white matter integrity were observed in stroke mice.

Conclusions:
Poststroke hMSC transplantation improves long-term stroke recovery in aged mice, likely via mechanisms involving enhanced microvascular regeneration and white matter restoration.
Scry, the Beloved Country: Sinofuturist Forecasting and Accelerationist Aesthetics
Authors: Conn Virginia L. 
Published: March 2023

Sinofuturism has emerged within the last 5 years as a compelling label for a wide variety of artistic and literary practices that posit China as “the future” and the future as “Chinese.” Yet this term remains broadly undertheorized outside of accelerationist spheres, where it is often taken as a self-evident truism. In this piece, I explore how—despite its many and varied instantiations—sinofuturist approaches broadly share a preoccupation with temporal surveillance that reinterprets the past as a precondition of an inevitable future, thereby enrolling viewers/readers in the creation of such a future. This practice has a longer history than the term itself presupposes, although the contemporary reimagining of sinofuturist characteristics as part of a globalized, self-defining network is almost entirely a result of engagement with internet technologies. Sinofuturism, despite its short history, carries deterministic paths (and assumptions) in its representations that constrain the potential for plural futures.