bluuebunny/crossref_metadata_2025_split huggingface dataset:
From Eligibility to Diagnosis: Candidacy and the Complex Journey of Cerebral Palsy Diagnosis Within Primary Care.
Authors: Baggaley Jessica Jeanette Evelyn , Seiboth Charlotte , Rapley Tim , Basu Anna 
Published: September 2023

Abstract
Background: Cerebral Palsy (CP) is an umbrella term for a group of permanent postural and movement conditions caused by non-progressive damage to the developing brain. Infants not identified with risk factors for CP at around the time of birth on average receive referral from primary care after the two years of age limit for early therapy. Candidacy, a seven-step dynamic theory, describes how individuals negotiate their eligibility for medical attention with themselves, others, and health services. This study aims to explore the CP diagnostic journey for community identified infants using the concept of candidacy.
Methods: Data was combined from two studies: an online survey of caregivers of children with CP about their earliest concerns and diagnosis journeys (n=255), and a series of interviews to support the development of a new tool to facilitate earlier identification of infants with emerging motor difficulties (11 parents, 11 health care professionals [HCPs]). A framework thematic analysis was used with a semantic, critical realist approach. An initial analysis was framed by the Andersen Model of Total Patient delay, and then conceptualised using Candidacy.
Results: Participants had difficulties identifying whether their child needed medical attention, prompting online searches, and seeking advice from family and friends. HCP adjudications led to immediate or delayed referral, in which families continued their searches and reappearing at services until a referral was made. Once referred, families faced poor operating conditions, such as long waiting times. After learning the diagnosis criteria, participants began making requests and navigated to private services when denied. Participants felt that more information on infant development from a reliable source is needed to support new parents in raising their concerns to aid earlier identification.
Conclusion: Participants identified personal lack of infant development knowledge as being the limiting factor to earlier referral. Further research is needed to develop materials relevant for the UK and to understand GP perspectives regarding provision of such materials.
Numerical and experimental investigations of flow separation control through a linear compressor cascade
Authors: EL-Sheikh Mohamed , Elbatsh Hesham , Zanoun Elsayed , Attia Ali 
Published: September 2023

Abstract
Modern large-scale gas turbines are equipped with high-pressure ratio compressors to increase engine work and its overall efficiency. Flow separation and energy losses are also two interrelated phenomenon associated with changes in compressor loading level and performance. This paper examines therefore the control of flow separation using a passive-control technique. An arced divergent-convergent slot grooved from the blade pressure side to its suction side was adopted to control flow separation, reducing the losses through a linear compressor cascade. The spanwise location of the slot was selected based on CFD simulations where the corner separation was predicted. The slot height in the spanwise direction was selected to be 8% of the blade height at the end-wall side. The present work was performed experimentally and numerically at an inlet Reynolds number, \({R}_{ec}=\rho {V}_{\infty }C/\mu =2.98\times {10}^{5}\), covering a wide range of incidence angles from \(+{6}^{^\circ } \text{t}\text{o}-{6}^{^\circ }\). The experimental work was carried out using a linear cascade test section consisting of six NACA 65 − 009 blade profiles integrated into a low-speed wind tunnel. A five-hole pressure probe system was used to obtain main flow parameters. Numerically, four turbulence models, including Spalart-Allmaras (S-A) model, Realizable (R k-ε) model, Shear-Stress Transport (SST k-ω) model, and Reynolds Stress model (RSM) were tested to predict the velocity and pressure fields. Good agreement between the experimental measurements and the numerical results, which were obtained using the RSM turbulence model in terms of velocity profiles and total pressure downstream of blades. It was observed also that the use of the arced-slotted blades for positive incident angles was more effective in reducing the separation than the negative and zero incident angles, approaching a maximum value of 33% for \({6}^{^\circ }\) with enhanced blade loading reaching 17.6%. It is to be concluded that, the use of arced slotted blade improves the compressor performance specially for positive incident angles.
RETRACTED: Safety and tolerability of STP1 (PDE 3,4 inhibitor and NKCC1 inhibitor), in a subgroup of ASD patients (ASD-Phen1)
Authors: Gomez-mancilla Baltazar , Erickson Craig A , Pedapati Ernest , Painbeni Eric , Bonfils Gregory , Schmitt Lauren M. , Sachs Hannah , Will Meredith , DeStafano Lisa , Westerkamp Grace , De Souza Adriano , Pohl Oliver , Laufer Offir , Issachar Gil , Hyvelin Jean-Marc , Durham Lynn A. 
Published: September 2023

Abstract
The authors have requested that this preprint be removed from Research Square.
The Implementation of Sustainable Practices in achieving sustainability Goals in Middle Eastern Universities
Authors: Ugbaja Solomon Chukwuemeka 
Published: September 2023

Abstract
The aim of this study is to assess the implementation of sustainability practices in Middle Eastern universities. The primary research question focuses on how universities are integrating sustainability practices, particularly in relation to the CORE system, which includes Curriculum, Operations, Research, and Engagement. The research methodology primarily involves content analysis of the UI GreenMetric ranking and universities' websites of selected universities in the Middle East, based on the UI GreenMetric Sustainable University assessment and ranking index, to observe their sustainability practices. The UI GreenMetric ranking is chosen because it takes into account the Operations, Curriculum, Research, and Engagements of universities, encompassing indicators such as Setting and Infrastructure, Energy and Climate Change, Waste, Water, Transportation, and Education. This comprehensive approach covers all three dimensions of sustainability (Environment, Economy, and Society), whereas other indexeslike GASU, AASHE: STAR, ESM and others, often focus mainly on operational Eco-efficiency. The sample for the study is selected from the top 224 sustainable universities ranked by the UI GreenMetric. The total population observed and evaluated consists of the top 29 Sustainability-focused Universities in the Middle East for the years 2021 and 2022, according to the UI GreenMetric sustainable ranking. Observations from the study indicate that the universities under review prioritize sustainability as part of their objectives and have developed plans, policies, and strategies to implement some of their sustainability goals, particularly concerning their management practices. However, the findings suggest that the universities should enhance their efforts in the Operational Eco-efficiency aspect of the CORE system, including areas like setting and infrastructure, energy and climate change, waste reduction/recycling, water conservation, and transportation. Additionally, the Education aspect, which covers Curriculum, Research, and Engagement, shows that all the studied universities perform above average, but they should invest further effort in this area, given its crucial role in educating students and society about sustainability.
Radical nephrectomy for a giant chromophobe renal cell carcinoma diagnosed &gt; 17 years previously: A case report and literature review
Authors: Lan Jianhua , Lan Dong , Yuan Wenqiang , Ying Qiao , He Jiahong , Gu Yonglin 
Published: September 2023

Abstract
Early diagnosis of renal cell carcinoma relies on imaging tests such as ultrasound, computed tomography, or magnetic resonance imaging. Since surgery is associated with a favorable prognosis, the standard treatment for clinically limited renal cell carcinoma remains surgical resection. Among asymptomatic patients with localized renal cell carcinoma, a small number refuse surgical treatment and survive. We report a case involving a 59-year-old female who underwent difficult radical nephrectomy 17 years after being diagnosed with malignant tumors due to primary renal cell carcinoma.
Mycogenic Synthesis of gold nanoparticles mediated by the endophytic fungi Colletotrichum gloeosporioides, with special reference to In Vitro and In Silico studies
Authors: Rajasekar Arvindganth , Govindarajan Kathiravan , Deivasigamani Priyadharsini 
Published: September 2023

Abstract
The Mycogenic prospects of gold nanoparticles (AuNPs) using endophytic fungi C. gloeosporioides was evaluated. The AuNPs were confirmed and characterized by using UV –Vis spectroscopy with the shape and size of the nanoparticles ranging from 0.5 to 1 nm, depending on Scanning and Transmission microscopy. In addition, spot the capping factor responsible for the reduction of gold ions and the stabilization of nanoparticles prepared FTIR. The X-ray diffraction corresponds to the intense peaks at 2θ values recorded. The GCMS analysis studies showed the presence of active compounds Heptadecanoic acid, 16-methyl,-methyl ester AuNPs exhibited. In vitro anticancer activity against breast cancer cell line
MCF-7 with different concentrations such as 100, 50, 25, 12.5, 6.25, 3, 3.125, 1.562 and 0.781 μg/ml were treated. The cell viability in the percentage of the respective concentration was about 15.33 to 77.90. The synthesize synthesized mycogenic associated nanoparticles derived active major compound Heptadecanoic acid, 16-methyl,-methyl ester ligand was indicate good activity against BRCA 1 and HER 2 breast cancer cell line protein receptor. The present investigation reports it gives a clear role in the therapeutic and biocatalytic contribution of synthesized mycogenic gold nanoparticles.
Trends in visits to a 24-hour walk-in crisis mental health centre during the COVID-19 pandemic
Authors: Lemoine Jocelyne , Jiang Depeng , Vakil Tanvi , Bolton James , Hensel Jennifer 
Published: September 2023

Abstract

Objective:Visit rates were examined at a 24-hour mental health crisis centre in Manitoba, Canada that offered in-person and virtual crisis assessments in a stepped care model during the COVID-19 pandemic.
Methods: All visits from the three years prior to the pandemic until September 28, 2022 were retrieved from the electronic patient record. Mean weekly visits had the pandemic not occurred were predicted with an autoregressive integrated moving average model and compared with observed rates.
Results: Visit rates remained lower than predicted throughout the observation period, with the total number of visits reduced by an average of 34.1 per week (p <.001) at the onset of the pandemic (first wave), and that gap narrowing to an average of 18.9 visits per week (p=0.001) during the fourth wave. Thirteen percent of pandemic visits were virtual; highest during the first wave of the pandemic (average of 34.1% of visits per week) and decreased to an average of 5.6% of visits per week during the last measured period.
Conclusion: Further investigation is necessary to better understand this sustained pattern of reduced service utilization as we move beyond the pandemic.
Right Ventricular Dyssynchrony for the Prediction of Prognosis in Patients with Systemic Lupus Erythematosus-Aaociated Pulmonary Arterial Hypertension: A Study with Two-Dimensional Speckle Tracking
Authors: Tan Xiao-Lan , Deng Yan , Lan Wei-Fang , Dai Ping , Hu Jie , Lan Jing 
Published: September 2023

Abstract
Purpose
Pulmonary arterial hypertension (PAH) is a common complication of systemic lupus erythematosus (SLE), and PAH can cause right ventricle (RV) remodel and dyssynchrony. The aim of this study was to explore the value of RV dyssynchrony in predicting adverse clinical events in patients with systemic lupus erythematosus-aaociated pulmonary arterial hypertension (SLE-PAH) using two-dimensional speckle tracking echocardiography (2D-STE).
Methods
A total of 53 patients with SLE-PAH were assigned to an adverse clinical event group and a non-adverse clinical event group. The dyssynchrony of the RV (RV-SD6) was evaluated by 2D-STE. The clinical data of all participants were collected, and routine cardiac function parameters were measured by two-dimensional echocardiography, and analyzed for their correlation with RV-SD6. The predictive value of RV-SD6 in clinical adverse event was evaluated.
Results
RV-SD6 was negatively correlated with RV-FLS, RV-FAC, and TAPSE (r=-0.788, r=-0.363 and r=-0.325, respectively, all P < 0.01), while the correlation with RV-FLS was the strongest. linear regression analysis showed that RV-FLS was an independent risk factor for RV-SD6 (β=-1.40, 95% CI -1.65 ~ -1.14, P < 0.001). Cox regression analysis showed that RV-SD6 was independently associated with clinical adverse events (HR = 1.03, 95% CI 1 ~ 1.06, P < 0.05). RV-SD6 was highly discriminative in predicting clinical adverse events (AUC = 0.764), at a cutoff of 51.10 ms with a sensitivity of 83.3% and specificity of 68.3%.
Conclusion
RV-FLS was negatively correlated with RV-SD6 and was an independent risk factor for it. RV-SD6 can serve as an indicator for predicting the occurrence of adverse clinical events in SLE-PAH patients, with high sensitivity and specificity.
Is India’s reluctance to join the Belt and Road Initiative a missing opportunity? Synthetic Control Method Analysis.
Authors: Elish Eman , Ahmed Hossam Eldien 
Published: September 2023

Abstract

Eight years have passed since the launch of the Belt and Road Initiative (BRI) in 2013 which was put into action in 2014. Since then, a series of research papers have categorized their findings in relation to the initiative’s aims, targets, and estimations of possible outcomes. This research intends to measure the impact of India’s resilience to join this initiative on its net foreign direct investment by comparing its trajectory to the trajectory of the same outcome for a counterfactual unit of comparison from countries that have joined the initiative. The method that will be employed is the Synthetic control method (SCM) for a panel of 27 countries between 1990 to 2021. The empirical results show that the net Foreign Direct Investment FDI trajectory for India during the eight years from 2014 to 2021 has fallen compared to synthetic India constructed from BRI member countries. This research study is distinctive from other empirical contributions by using an inventive technique of SCM, which is a new experimental method to assess actual outcomes rather than predicting them, as in other conventional regression models. Moreover, the economic aspect of accessing the BRI has rarely been investigated, since most studies have qualitatively focused on the political aspect of the initiative. The results can assist in decision-making for India and other countries considering membership in this millennium initiative.
A Walk on Entrepreneurial Path: A Journey of Young Entrepreneurs
Authors: Sait Sofia Ahmed , Kasmir Mrs Lekha 
Published: September 2023

Abstract
The study "A Walk on the Entrepreneurial Path: A Study Showcasing Young Entrepreneurs" looks at the factors that affect young entrepreneurs' motivation. The study found that financial gain and professional autonomy are the two most significant motivators, followed by creativity, hardest work, and making a beneficial impact. Important internal management problems, such as a lack of expertise and knowledge, time management, marketing and sales, burnout and stress, and external environmental problems, such as financial, competitive, legal, and regulatory challenges, were also noted by the study. The study emphasizes the significance of access to capital, mentorship and networks, as well as recognition and assistance for young entrepreneurs, in order to overcome these difficulties. Furthermore, the report contends that adaptability and creativity, accessibility to tools and resources, and assistance from governments and policies may all help young entrepreneurs succeed and have a beneficial impact in the cutthroat economic environment. Overall, the study emphasizes the chances young entrepreneurs have to overcome obstacles and be successful in their business endeavors.
Parameters estimation and curves analysis for faults evaluation of a degraded photovoltaic module
Authors: AYANG ALBERT , Goron Deli , Mbakop Fabrice Kwefeu , . Yaouba , Saad Mohamad 
Published: September 2023

Abstract
In the present work, a fault evaluation method for photovoltaic arrays based on fault parameters identification and curves analysis is proposed for diagnosing the state of photovoltaic generators. An overview of the components, the modelling of the photovoltaic generator and the meaning of the parameters is established for relating parameters to photovoltaic components and environmental conditions. The analysis and investigation of the relationship between the maximum power points and the parameters variations are performed. Investigation on how degradations and failure on photovoltaic systems can affect parameters, is established. In this context, the methodology for diagnosing and monitoring defects based on photovoltaic estimated parameters is developed; the optimization technique maximum likelihood, is used for extracting health and faults parameters from the measured curves of the photovoltaic array. From residual vectors, the parameters which vary more are the series resistance, the shunt resistor, and the current of photon. The maximum power also changes and decreases from its reference value. The validation results prove deviations on parameters, which means that there are degradations and failures on the ARCO Solar M75 array after 20 years of outdoors operation. So, at the end of this analysis, it is recommended to act on the PV system through junction box, cell edges, wiring, busbars, and connectors.
A human cadaveric model for venous air embolism tool development
Authors: Robinson Nathaniel L. , Marcellino Chris , Johnston Matt , Abcejo Arnoley S. 
Published: September 2023

Abstract

Purpose
A human cadaveric model combining standard lung protective mechanical ventilation and modified cardiac bypass techniques was developed to allow investigation into automated modes of detection of venous air emboli (VAE) prior to in vivo human or animal investigations.
Methods
In this study, in order to create an artificial cardiopulmonary circuit in a cadaver that could mimic VAE physiology, the direction of flow was reversed from conventional cardiac bypass. Saline was circulated in isolation through the heart and lungs as opposed to the peripheral organs by placing the venous cannula into the aorta and the arterial cannula into the inferior vena cava with selective ligation of other vessels.
Results
Mechanical ventilation and this reversed cardiac bypass scheme allowed preliminary detection of VAE independently but not in concert in our current simulation scheme due to pulmonary edema in the cadaver. A limited dissection approach was used initially followed by a radical exposure of the great vessels, and both proved feasible in terms of air signal detection. We used electrical impendence as a preliminary tool to validate detection in this cadaveric model however we theorize that it would work for echocardiographic, intravenous ultrasound or other novel modalities as well.
Conclusion
A cadaveric model allows monitoring technology development with reduced use of animal and conventional human testing.
A Lightweight Log-Monitoring-Based Mitigation Tool Against WLAN Attacks
Authors: Saifan Ramzi , Radi Mohammad , Al-Dabbagh Hamsa , Mansour Badr 
Published: September 2023

Abstract
Wireless network attacks are some of the most common network security threats dealt with on a daily basis. Their ease of execution and effectiveness make them commonplace within most public networks. The goal of this paper is to develop a tool which provides defenses against these attacks, one which can also generate the attacks to test its own effectiveness in defending against them. The research involved the design, testing, and implementation of an attack/defense tool, one which benefits from a user-friendly user interface that greatly simplifies the testing process. The attacks were generated using existing tools, linked to one central interface. The defense methodology was script-based and created entirely from scratch. It was also linked to a single interface which continuously monitored logs. The results showed that the proposed defenses to the studied wireless attacks were effective at mitigation, or outright prevention. They were also more lightweight than existing solutions, making them more appealing for less powerful hardware.
Middle East Nurses Turnover Intention and Its Correlates Amid the Covid-19 Pandemic; A Systematic Review
Authors: Kunjavara Jibin , Alomari Albara Mohammad Ali , Mannethodi Kamaruddeen , Hassan Nesiya , Singh Kalpana , Joy George Vellaramcheril , Lenjawi Badriya Al 
Published: September 2023

Abstract
Global nursing scarcity was more evident during COVID-19. This study investigated the rates and contributing factors of turnover intention in the middle east through meta-analysis. Medline EMCARE, Cochrane, CINAHL, EMBASE, Ovid, Psych Info, PubMed, Science Direct, Scopus, and Web of Science databases searched, Protocol PROSPERO Registration Number was CRD42022337686. The turnover intention rate was 42.3% [CI:40%, 44.6%]. Working environment, stress, deployment to Covid, fear of infection, long working hours, shift duties, and lack of social support were the major contributing factors.
WITHDRAWN: Multi-omics predicts risk factors for kidney disease associated with RNA modification
Authors: Liu Xinran , Zhu Sai , Liu Xueqi , Luo Xiaomei , Wang Yikai , Chen Chaoyi , Jiang Ling , Wu Yonggui 
Published: September 2023

Abstract
Background
More and more evidence suggests that RNA modification play significant roles in kidney and may be ideal targets of kidney diseases. However, the specific mechanisms of RNA modification in the pathogenesis of kidney diseases remain unclear. Genome-wide association study (GWAS) have identified lots of genetic loci for kidney function and RNA modification. The identification and exploration of the functions of kidney function associated with RNAm-SNPs can help us to explore comprehensive understanding of the underlying mechanism of kidney disease and find potential therapeutic targets.
Methods
First, we examined the association of RNAm-SNPs with kidney function. Secondly, we performed eQTL and pQTL analyses to explore the function of these identified RNAm-SNPs. Finally, we evaluated the causality between RNAm-SNPs associated gene expression and circulating protein and kidney function by using mendelian randomization analysis and Bayesian colocalization test (coloc).
Results
370 RNAm-SNPs related to m6A, m1A, A-to-I, m5C, m7G and m5U modifications were identified. All of them was significantly associated with kidney function. Most of these RNAm-SNPs (60.27%) showed cis-eQTL effects in kidney tissues or in blood cells, while 78 RNAm-SNPs (21.08%) showed cis-pQTL effects in plasma. In addition, we demonstrate a causal association of some RNAm-SNPs associated gene expression and circulating protein with the risk for kidney function. Notably, we demonstrate a causal association of the gene expression in blood and plasma protein of ITIH4 with the risk for kidney function.
Conclusions
The study found the associations between RNAm-SNPs and kidney function. These SNPs can regulate gene expression and protein levels by RNA modification, eventually leading to kidney dysfunction. Our study provided direct evidences that connect the genetic risk of kidney disease to RNA modification and the new idea for potential therapeutic targets of prevention and treatment of kidney disease.