bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analisis shooting dan passing terhadap akurasi tendangan pada tim U-19 Sheyfa Futsal Academy Kendal
Authors: Mahendra Bangkit Yusril , Irawan Fajar Awang , Prastiwi Tania Arlita Safitri , Trans Minh Nghia Le 
Published: February 2023

Tujuan dari penelitian ini yaitu untuk mengetahui hasil analisis shooting dan passing terhadap akurasi tendangan pada tim U-19 Sheyfa Futsal Academy Kendal. Seluruh pemain U-19 putra Sheyfa Futsal Academy menjadi populasi dan sampel pada penelitian ini. Metode penelitian yang digunakan berupa Pilot Study karena hanya dilakukan pada satu pertandingan saja. Data diperoleh dengan cara melakukan analisis pada pertandingan trofeo yang dilaksanakan pada tanggal 22 Maret 2022 menggunakan scoresheet pada setiap pertandingan selama 2x20 menit. Data kemudian dianalisis menggunakan Microsoft Excel 2013 untuk diperoleh rata-rata dan persentase. Hasil penelitian menunjukkan bahwa shooting pemain kategori cukup sebesar 40% dengan total pemain pada kategori ini sebanyak 8 orang. Sedangkan 12 pemain lain berada pada kategori baik dengan persentase sebesar 60%. Tingkat keakuratan passing yang dihasilkan oleh sampel, yang berada pada kategori baik sebesar 45% dengan jumlah pemain sebanyak 9 orang. Sampel yang berhasil melakukan passing dengan kategori sangat baik berjumlah 11 orang dengan hasil persentase sebesar 55%. Peneletian yang akan datang, diharapkan dapat menggunakan sampel yang jumlahnya lebih besar serta membahas terkait hal-hal yang mempengaruhi tingkat akurasi Â passing dan shooting.Â Â Â Analysis of shooting and passing on kick accuracy in the U-19 Sheyfa Futsal Academy Kendal teamAbstract: The purpose of this study was to determine the results of shooting and passing on kick accuracy on the u-19 team at Sheyfa Futsal Academy Kendal. All male U-19 players of Sheyfa Futsal Academy became the population and sample in this study. The research method used is descriptive quantitative. The data was obtained by analyzing the Trofeo match, which was held on March 22, 2022, using a scoresheet in each match for 2x20 minutes. The data was then analyzed using Microsoft Excel 2013 to obtain the average and percentage. The results showed that the shooting category of players was sufficient by 40%, with a total of 8 players in this category. While the other 12 players are in the good category with a percentage of 60%. The level of accuracy passing produced by the sample, which is in the good category, is 45% with a total of 9 players. The sample who succeeded in passing in the very good category was 11 people with a percentage result of 55%. Future research is expected to be able to discuss matters that affect the level of accuracy of passing and shooting.
Tuning Database Pada Sistem Penerimaan Mahasiswa Baru Menggunakan Optimasi Query dan Indexing
Authors: Deska Amat , Akbar Ipal , Samidi - 
Published: February 2023

Dalam pengoperasian database MaraiaDB diperlukan aplikasi berupa server localhost yang memiliki response waktu untuk menjalankan sebuah query agar dapat mendapatkan waktu yang efisiensi. Pada penelitian ini mengukur perfoma query dalam bentuk SELECT pada database MariaDB yang sudah di install pada komputer atau laptop dengan menggunakan aplikasi yang bernama Xammp dengan jumlah record data kurang lebih sebanyak 12.000 data, tapi pada penelitian ini hanya memakai sekitar 5000 data. Data tersebut nantinya akan dilakukan optimasi query dan indexing. Permasalahan yang terjadi adalah lamanya proses pengambilan data yang membutuhkan waktu sehingga membutuhkan suatu cara agar dapat mempercepat proses pengambilan data. Metode optimasi database yang difokuskan pada pengujian ini adalah dengan melakukan perbandingan dari berbagai efektivitas sub query serta penggunaan indexing pada tabel. Pada Query yang diuji adalah fungsi yang bernama LEFT JOIN, WHERE, ON, GROUP BY, ORDER BY dan DML (Data Manipulation Language), yaitu QUERY SELECT yang akan di lakukan pada aplikasi Xammp. Pada penelitian ini hasil yang di harapkan berupa pengambilan data yang akan menjadi lebih cepat atau efisien untuk meningkatkan kinerja pada database setelah melakukan Optimasi SQL Query dan Table Indexing.
RANCANG BANGUN SISTEM INFORMASI E-MARKETING PADA PT PULAU CAHAYA TERANG
Authors: Tukino Tukino 
Published: February 2023

Current technological developments are increasing, one of which is the development of the internet that is very fast, many companies are starting to offer their products through the internet to maximize their profits, so that competition between companies is getting tighter. PT Pulau Cahaya Terang is one company that manufactures and sells various types of spring beds and equipment in the city of Batam. The sales system is by the way consumers come directly to the company, contact by telephone, or the company offers products directly through salesmen, the system Used is less effective now, becaUse consumers find it difficult to get the latest information and making an order quickly. For this reason, it is necessary to create a web-based sales information system at PT Pulau Cahaya Terang so that consumers can easily access product information and can also directly order and pay for products through the website. The method Used is the SDLC Waterfall model which consists of needs analysis, design, programming code, testing, implementation and maintenance. The results of this research are a website-based sales information system that makes it easier for consumers to obtain information and order products, and save employee costs and time
Exploration and verification of COVID-19-related hub genes in liver physiological and pathological regeneration
Authors: Shi Jihang , Li Guangya , Yuan Xiandun , Wang Yafei , Gong Ming , Li Chonghui , Ge Xinlan , Lu Shichun 
Published: February 2023

Objectives An acute injury is often accompanied by tissue regeneration. In this process, epithelial cells show a tendency of cell proliferation under the induction of injury stress, inflammatory factors, and other factors, accompanied by a temporary decline of cellular function. Regulating this regenerative process and avoiding chronic injury is a concern of regenerative medicine. The severe coronavirus disease 2019 (COVID-19) has posed a significant threat to people’s health caused by the coronavirus. Acute liver failure (ALF) is a clinical syndrome resulting from rapid liver dysfunction with a fatal outcome. We hope to analyze the two diseases together to find a way for acute failure treatment.Methods COVID-19 dataset (GSE180226) and ALF dataset (GSE38941) were downloaded from the Gene Expression Omnibus (GEO) database, and the “Deseq2” package and “limma” package were used to identify differentially expressed genes (DEGs). Common DEGs were used for hub genes exploration, Protein-Protein Interaction (PPI) network construction, Gene Ontology (GO) functional enrichment, and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment. The real-time reverse transcriptase-polymerase chain reaction (RT-qPCR) was used to verify the role of hub genes in liver regeneration during in vitro expansion of liver cells and a CCl4-induced ALF mice model.Results: The common gene analysis of the COVID-19 and ALF databases revealed 15 hub genes from 418 common DEGs. These hub genes, including CDC20, were related to cell proliferation and mitosis regulation, reflecting the consistent tissue regeneration change after the injury. Furthermore, hub genes were verified in vitro expansion of liver cells and in vivo ALF model. On this basis, the potential therapeutic small molecule of ALF was found by targeting the hub gene CDC20.Conclusion We have identified hub genes for epithelial cell regeneration under acute injury conditions and explored a new small molecule Apcin for liver function maintenance and ALF treatment. These findings may provide new approaches and ideas for treating COVID-19 patients with ALF.
Repeated and multiple fecal microbiota transplantations plus partial enteral nutrition as the first-line treatment in active pediatric Crohn’s disease
Authors: Zou Biao , Liu Shengxuan , Li Xuesong , He Jiayi , Dong Chen , Ruan Mengling , Huang Zhihua , Shu Sainan 
Published: February 2023

BackgroundMost studies have reported fecal microbiota transplantation (FMT) as an effective secondary option for Crohn’s disease (CD). However, there is little data on FMT as a first-line treatment for CD. In our study we explore the rates of clinical and endoscopic remission and mucosal healing after FMT plus partial enteral nutrition (PEN), as a first-line treatment for active CD in children.MethodsWe retrospectively enrolled pediatric CD patients who underwent PEN or PEN plus FMT treatment at diagnosis from November 2016 to July 2019 at the Pediatric Department, Tongji Hospital. The two groups were defined as FMT group (repeated and multiple doses of FMT plus PEN) or PEN group (PEN alone). All the patients received PEN intervention. At baseline and week 8- 10, the FMT group was administered multiple doses of FMT to help induce and maintain remission. All patients were evaluated at week 8- 10 and 18-22 via clinical and relevant laboratory parameters and endoscopic results. The clinical and endoscopic remission and mucosal healing rates were compared between the two groups at different time points after the therapy.ResultsTwenty-five newly diagnosed active CD patients were included in the study, containing 7 females and 18 males with a median age of 11. 1 ± 2.3 years. 13 and 12 patients were assigned to the PEN and FMT groups, respectively. At week 8-10, clinical remission was obtained in 83.3% and 53.8% of the FMT and PEN groups, respectively (p=0.202). The endoscopic remission rates were 72.7% for FMT and 25.0% for PEN (p=0.039), whereas the mucosal healing rates were 27.2% for FMT and 0% for PEN (p=0.093). At week 18-22, clinical remission was achieved in 72.7% and 20.0% of patients in the FMT and PEN groups, respectively (p=0.03). Theendoscopic remission rates were 66.6% and 12.5% in the FMT and PEN groups, respectively (p=0.05), whereas the mucosal healing rates were 55.5% and 0% in FMT and PEN groups, respectively (p=0.029).ConclusionThis study demonstrate that FMT plus PEN can be used as a first-line treatment for active CD in children.
SMS-text messaging for collecting outcome measures after acute stroke
Authors: DiCarlo Julie A. , Erler Kimberly S. , Petrilli Marina , Emerson Kristi , Gochyyev Perman , Schwamm Lee H. , Lin David J. 
Published: February 2023

IntroductionTraditional methods for obtaining outcomes for patients after acute stroke are resource-intensive. This study aimed to examine the feasibility, reliability, cost, and acceptability of collecting outcomes after acute stroke with a short message service (SMS)-text messaging program.MethodsPatients were enrolled in an SMS-text messaging program at acute stroke hospitalization discharge. Participants were prompted to complete assessments including the modified Rankin scale (mRS) and Patient-Reported Outcomes Measurement (PROM) Information System Global-10 at 30, 60, and 90 days postdischarge via SMS-text. Agreement and cost of SMS-text data collection were compared to those obtained from traditional follow-up methods (via phone or in the clinic). Participant satisfaction was surveyed upon program conclusion.ResultsOf the 350 patients who agreed to receive SMS texts, 40.5% responded to one or more assessments. Assessment responders were more likely to have English listed as their preferred language (p = 0.009), have a shorter length of hospital stay (p = 0.01), lower NIH stroke scale upon admission (p &lt; 0.001), and be discharged home (p &lt; 0.001) as compared to nonresponders. Weighted Cohen’s kappa revealed that the agreement between SMS texting and traditional methods was almost perfect for dichotomized (good vs. poor) (κ = 0.8) and ordinal levels of the mRS score (κ = 0.8). Polychoric correlations revealed a significant association for PROM scores (ρ = 0.4, p &lt; 0.01 and ρ = 0.4, p &lt; 0.01). A cost equation showed that gathering outcomes via SMS texting would be less costly than phone follow-up for cohorts with more than 181 patients. Nearly all participants (91%) found the program acceptable and not burdensome (94%), and most (53%) felt it was helpful. Poststroke outcome data collection via SMS texting is feasible, reliable, low-cost, and acceptable. Reliability was higher for functional outcomes as compared to PROMs.ConclusionsWhile further validation is required, our findings suggest that SMS texting is a feasible method for gathering outcomes after stroke at scale to evaluate the efficacy of acute stroke treatments.
Effect of feedback through dynamic assessment on EFL field-dependent and field-independent learners’ speaking skill development
Authors: Kafipour Reza , Khoshnood Ali 
Published: February 2023

IntroductionTesting and assessment tools evaluate students’ performance in a foreign language. Moreover, the ultimate goal of tests is to reinforce learning and motivate students. At the same time, instructors can gather information about learners’ current level of knowledge through assessment to revise and enhance their teaching. This study aimed to investigate the effect of Dynamic Assessment on Iranian English as a Foreign Language (EFL) learners’ speaking skills by considering language learners’ cognitive styles (field dependence and field independence).MethodsFor this purpose, 60 Iranian intermediate-level EFL female learners were selected through convenience sampling from three language institutes with similar teaching methods in Shiraz, Iran. The current study has a quasi-experimental design since randomization was impossible. First, the authors used the Nelson Proficiency test and interview to determine the participants’ proficiency level and speaking ability, respectively. Next, they took the group embedded figures test (GEFT) to determine the participants’ type of cognitive style (field dependence or field independence). Next, the participants were randomly assigned to two experimental (FD and FI learners with the dynamic assessment) and two control groups. Paired and independent-sample t-test were applied to analyze the data.Results and discussionResults revealed that although dynamic assessment was effective for both experimental groups, the Field-dependent group with dynamic assessment outperformed the other. Thus, it can be concluded that in addition to the dynamic assessment, language learners’ cognitive style can also play a vital role in increasing the assessment effectiveness. This type of assessment attracts instructors’ attention to learners’ potential to help the language learners gradually improve their performance. In addition, language institutes can introduce this new way of assessment in their advertisements and attract more students, leading to higher income and publicity for them.
Determination of ecological flow thresholds for rainfall-recharging rivers based on multiple hydrological methods
Authors: Yu Jiandong , Yu Shouchao , Zhang Hengjia , Wang Zeyi , Zhou Chenli , Chen Xietian 
Published: February 2023

Given the threats to the regional river ecological flow, including the sharp increase in per capita water demand, the increase in the number of hydraulic engineering, and the strong seasonal runoff of rainfall recharge channels, we clarified the appropriate ecological flow thresholds for the middle reaches of Bailong River of northwest China. Based on the monthly runoff data in the Wudu Hydrological Station of Bailong River from 1990 to 2020, seven suitable hydrological methods were used to couple the estimation of the ecological flow in the middle reaches of Bailong River, which were tested by runoff satisfaction level analysis, using quadratic fit and 95% confidence interval to determine the monthly ecological flow and threshold of the river in the study area. The results by using the single hydrological methods showed that the calculation results from the monthly minimum ecological runoff calculation method, the improved RVA method, the Tennant method, and the DC method were four better estimation methods, which had a satisfaction level of more than 90% in the whole year. The improved RVA method and the Tennant method were more suitable for the diversion power station whose main task aimed at power generation. Although the economic benefits of hydropower stations were better when the improved RVA method was used to calculate ecological flow, the calculation results from the improved RVA method were tested and analyzed by the Tennant method, which were extremely poor from November to April in the following year, and could not meet the minimum ecological water requirements for the biological community in the river channel. While the other five methods all meet this requirement. We suggest that the minimum ecological flow in the middle reaches of the Bailong River maintained at 27.28 m3⁄s, and the maximum retained at 116.33 m3⁄s. The calculation results were in line with the dynamics of runoff in the study area, which could improve the accuracy of water ecological protection. The calculation results of this study could be used for the middle reaches of the Bailong River and may provide a reference for follow-up ecological restoration research and management in similar ecological zones.
A combination of HLA-DP α and β chain polymorphisms paired with a SNP in the DPB1 3’ UTR region, denoting expression levels, are associated with atopic dermatitis
Authors: Margolis David J. , Duke Jamie L. , Mitra Nandita , Berna Ronald A. , Hoffstad Ole J. , Wasserman Jenna R. , Dinou Amalia , Damianos Georgios , Kotsopoulou Ioanna , Tairis Nikolaos , Ferriola Deborah A. , Mosbruger Timothy L. , Hayeck Tristan J. , Yan Albert C. , Monos Dimitri S. 
Published: February 2023

Introduction: Components of the immune response have previously been associated with the pathophysiology of atopic dermatitis (AD), specifically the Human Leukocyte Antigen (HLA) Class II region via genome-wide association studies, however the exact elements have not been identified.Methods: This study examines the genetic variation of HLA Class II genes using next generation sequencing (NGS) and evaluates the resultant amino acids, with particular attention on binding site residues, for associations with AD. The Genetics of AD cohort was used to evaluate HLA Class II allelic variation on 464 subjects with AD and 384 controls.Results: Statistically significant associations with HLA-DP α and β alleles and specific amino acids were found, some conferring susceptibility to AD and others with a protective effect. Evaluation of polymorphic residues in DP binding pockets revealed the critical role of P1 and P6 (P1: α31M + (β84G or β84V) [protection]; α31Q + β84D [susceptibility] and P6: α11A + β11G [protection]) and were replicated with a national cohort of children consisting of 424 AD subjects. Independently, AD susceptibility-associated residues were associated with the G polymorphism of SNP rs9277534 in the 3’ UTR of the HLA-DPB1 gene, denoting higher expression of these HLA-DP alleles, while protection-associated residues were associated with the A polymorphism, denoting lower expression.Discussion: These findings lay the foundation for evaluating non-self-antigens suspected to be associated with AD as they potentially interact with particular HLA Class II subcomponents, forming a complex involved in the pathophysiology of AD. It is possible that a combination of structural HLA-DP components and levels of expression of these components contribute to AD pathophysiology.
Public perceptions and attitudes of the national project of bio-big data: A nationwide survey in the Republic of Korea
Authors: Yang Ji Hyun , Kim Hannah , Lee Ilhak 
Published: February 2023

Background: The National Project of Bio-Big Data (NPBBD) is a South Korean bio-big data collection project, expected to include health, genomic, and lifelog data of one million Koreans. The Ethical, Legal, and Social Implications study is a parallel study active since 2020. As part of the study, a public survey was conducted to evaluate public attitudes towards engagement schemes, such as public committees and web portals for communication between the public and researchers.Methods: An online survey was conducted from March 3–9, 2021, using structured questionnaires addressed to 1,000 adults aged 20–59 years.Results: Several respondents reported a positive attitude towards participation (43.6% “somewhat,” 14.3% “definitely”), whereas approximately one-third (36.5%) reported a neutral attitude. Positive factors that may affect the willingness of the respondents to participate included receiving health information (25.1%), contributing to research on cancer and rare diseases (21.9%), and advancing personalized medicine (21.5%). Conversely, negative factors were mainly associated with concerns regarding the risk of data leakage (22.8%), discrimination (21.1%), lack of information (13.5%), possibility of knowing the risk of being diagnosed with an incurable diseases (12.5%), and possibility of using data in industry (11.3%). In terms of project governance, respondents tended to recognize the importance of public participation in incorporating public opinion into the project design.Conclusion: These results have implications for the participant recruitment process, public engagement strategies, and the scope of user (academics/industry, domestic/overseas) accessibility to the database.
Potential diagnostic markers and therapeutic targets for rheumatoid arthritis with comorbid depression based on bioinformatics analysis
Authors: Zhou Tao-tao , Sun Ji-jia , Tang Li-dong , Yuan Ying , Wang Jian-ying , Zhang Lei 
Published: February 2023

BackgroundRheumatoid arthritis (RA) and depression are prevalent diseases that have a negative impact on the quality of life and place a significant economic burden on society. There is increasing evidence that the two diseases are closely related, which could make the disease outcomes worse. In this study, we aimed to identify diagnostic markers and analyzed the therapeutic potential of key genes.MethodsWe assessed the differentially expressed genes (DEGs) specific for RA and Major depressive disorder (MDD) and used weighted gene co-expression network analysis (WGCNA) to identify co-expressed gene modules by obtaining the Gene expression profile data from Gene Expression Omnibus (GEO) database. By using the STRING database, a protein–protein interaction (PPI) network constructed and identified key genes. We also employed two types of machine learning techniques to derive diagnostic markers, which were assessed for their association with immune cells and potential therapeutic effects. Molecular docking and in vitro experiments were used to validate these analytical results.ResultsIn total, 48 DEGs were identified in RA with comorbid MDD. The PPI network was combined with WGCNA to identify 26 key genes of RA with comorbid MDD. Machine learning-based methods indicated that RA combined with MDD is likely related to six diagnostic markers: AURKA, BTN3A2, CXCL10, ERAP2, MARCO, and PLA2G7. CXCL10 and MARCO are closely associated with diverse immune cells in RA. However, apart from PLA2G7, the expression levels of the other five genes were associated with the composition of the majority of immune cells in MDD. Molecular docking and in vitro studies have revealed that Aucubin (AU) exerts the therapeutic effect through the downregulation of CXCL10 and BTN3A2 gene expression in PC12 cells.ConclusionOur study indicates that six diagnostic markers were the basis of the comorbidity mechanism of RA and MDD and may also be potential therapeutic targets. Further mechanistic studies of the pathogenesis and treatment of RA and MDD may be able to identify new targets using these shared pathways.