bluuebunny/crossref_metadata_2025_split huggingface dataset:
$(H_{p}-L_{p})$-Type inequalities for subsequences of Nörlund means of Walsh–Fourier series
Authors: Baramidze David , Persson Lars-Erik , Tangrand Kristoffer , Tephnadze George 
Published: April 2023

AbstractWe investigate the subsequence $\{t_{2^{n}}f \}$
{

t

2
n

f
}
of Nörlund means with respect to the Walsh system generated by nonincreasing and convex sequences. In particular, we prove that a large class of such summability methods are not bounded from the martingale Hardy spaces $H_{p}$

H
p

to the space $\mathit{weak-}L_{p} $

w
e
a
k
−

L
p

for $0< p<1/(1+\alpha ) $
0
<
p
<
1
/
(
1
+
α
)
, where $0<\alpha <1$
0
<
α
<
1
. Moreover, some new related inequalities are derived. As applications, some well-known and new results are pointed out for well-known summability methods, especially for Nörlund logarithmic means and Cesàro means.
Melatonin promotes the development of the secondary hair follicles by regulating circMPP5
Authors: Diao Xiaogao , Yao Lingyun , Duan Tao , Qin Jiaxin , He Liwen , Zhang Wei 
Published: April 2023

Abstract
Background
The quality and yield of cashmere fibre are closely related to the differentiation and development of secondary hair follicles in the skin of cashmere goats. The higher the density of secondary hair follicles, the higher the quality and yield of cashmere from the fleece. Development of secondary hair follicles commences in the embryonic stage of life and is completed 6 months after birth. Preliminary experimental results from our laboratory showed that melatonin (MT) treatment of goat kids after their birth could increase the density of secondary hair follicles and, thus, improve the subsequent yield and quality of cashmere. These changes in the secondary hair follicles resulted from increases in levels of antioxidant and expression of anti-apoptotic protein, and from a reduction in apoptosis. The present study was conducted to explore the molecular mechanism of MT-induced secondary hair follicle differentiation and development by using whole-genome analysis.

Results
MT had no adverse effect on the growth performance of cashmere kids but significantly improved the character of the secondary hair follicles and the quality of cashmere, and this dominant effect continued to the second year. Melatonin promotes the proliferation of secondary hair follicle cells at an early age. The formation of secondary hair follicles in the MT group was earlier than that in the control group in the second year. The genome-wide data results involved KEGG analysis of 1044 DEmRNAs, 91 DElncRNAs, 1054 DEcircRNAs, and 61 DEmiRNAs which revealed that the mitogen-activated protein kinase (MAPK) signaling pathway is involved in the development of secondary hair follicles, with key genes (FGF2, FGF21, FGFR3, MAPK3 (ERK1)) being up-regulated and expressed. We also found that the circMPP5 could sponged miR-211 and regulate the expression of MAPK3.

Conclusions
We conclude that MT achieves its effects by regulating the MAPK pathway through the circMPP5 sponged the miR-211, regulating the expression of MAPK3, to induce the differentiation and proliferation of secondary hair follicle cells.
In addition there is up-regulation of expression of the anti-apoptotic protein causing reduced apoptosis of hair follicle cells. Collectively, these events increase the numbers of secondary hair follicles, thus improving the production of cashmere from these goats.
Potential roles of the rectum keystone microbiota in modulating the microbial community and growth performance in goat model
Authors: Wang Dangdang , Tang Guangfu , Zhao Lichao , Wang Mengya , Chen Luyu , Zhao Congcong , Liang Ziqi , Chen Jie , Cao Yangchun , Yao Junhu 
Published: April 2023

Abstract
Background
Ruminal microbiota in early life plays critical roles in the life-time health and productivity of ruminant animals. However, understanding of the relationship between gut microbiota and ruminant phenotypes is very limited. Here, the relationship between the rectum microbiota, their primary metabolites, and growth rate of a total of 76 young dairy goats (6-month-old) were analyzed, and then 10 goats with the highest or lowest growth rates respectively were further compared for the differences in the rectum microbiota, metabolites, and animal’s immune parameters, to investigate the potential mechanisms by which the rectum microbiota contributes to the health and growth rate.

Results
The analysis of Spearman correlation and microbial co-occurrence network indicated that some keystone rectum microbiota, including unclassified Prevotellaceae, Faecalibacterium and Succinivibrio, were the key modulators to shape the rectum microbiota and closely correlated with the rectum SCFA production and serum IgG, which contribute to the health and growth rate of young goats. In addition, random forest machine learning analysis suggested that six bacterial taxa in feces could be used as potential biomarkers for differentiating high or low growth rate goats, with 98.3% accuracy of prediction. Moreover, the rectum microbiota played more important roles in gut fermentation in early life (6-month-old) than in adulthood stage (19-month-old) of goats.

Conclusion
We concluded that the rectum microbiota was associated with the health and growth rate of young goats, and can be a focus on the design of the early-life gut microbial intervention.
“A calf cannot fail to pick a colour from its mother”: intergenerational transmission of trauma and its effect on reconciliation among post-genocide Rwandan youth
Authors: Kagoyire Marie Grace , Kangabe Jeannette , Ingabire Marie Chantal 
Published: April 2023

Abstract
Background
More than one million Rwandans were killed over a span of one hundred days during the 1994 genocide against the Tutsis. Many adult survivors were severely traumatized by the events, and young people, including those who were born after the genocide, have experienced similar genocide-related trauma. Building on a growing body of research on the generational transmission of trauma, our study addressed the following questions: (1) what are the possible mechanisms of trauma transmission from older generation to post-genocide Rwandan youth, and (2) what are the effects of intergenerational trauma on reconciliation processes in Rwanda.

Methods
A qualitative study was conducted in Rwanda among youth born after the genocide, with parents who survived the 1994 genocide against the Tutsis and among mental health and peace-building professionals. Individual interviews (IDIs) included 19 post-genocide descendants of survivors and six focus group discussions (FGDs) were conducted with 36 genocide survivor parents residing in Rwanda’s Eastern Province. Ten IDIs were also conducted with mental health and peace-building professionals in the capital city of Kigali. Respondents were recruited through five local organisations that work closely with survivors and their descendants. An inductive thematic analysis approach was used to analyse the data.

Results
Findings from this study suggest that the trauma experienced by genocide survivor parents is perceived by Rwandan youth, mental health and peace-building professionals, and survivor parents themselves to be transmitted from parent to child through human biology mechanisms, social patterns of silence and disclosure of genocide experiences, and children’s and youth’s everyday contact with a traumatized parent. Genocide-related trauma among survivor parents is seen as often being triggered by both life at home and the annual genocide commemoration events. Additionally, when transmitted to genocide survivor descendants, such trauma is understood to negatively affect their psychological and social well-being. Intergenerational trauma among youth with genocide survivor parents limits their involvement in post-genocide reconciliation processes. Findings specifically show that some youth avoid reconciliation with a perpetrator’s family due to mistrust as well as fear of re-traumatizing their own parents.
Psychometric properties of the Greek Version of the Traumatic Event Scale (TES) (Version A) among low-risk pregnant women
Authors: Varela Pinelopi , Lykeridou Aikaterini , Zervas Ioannis , Deltsidou Anna 
Published: April 2023

AbstractBackgroundThe Traumatic Event Scale (TES) is one of the most often used instruments for the assessment of the Posttraumatic Stress Disorder (PTSD) symptomatology during pregnancy which is linked with adverse effects. The aim of the study was to assess the psychometric properties of the TES (version A) in a sample of Greek pregnant women.MethodsTwo hundred one low risk pregnant women in their second or third trimester were invited to participate in the study. Participants completed a number of questionnaires including the Greek versions of TES-A, State-Trait Anxiety Inventory (STAI), Coping Orientations to Problems Experienced (Brief COPE), Perceived Stress Scale (PSS-10) and Edinburgh Postnatal Depression Scale (EPDS). Confirmatory factor analysis (CFA) was conducted in order to test how well the already TES-A five-factor model fits the data from Greece.ResultsParticipants’ average age was 34.2 years (SD = 4.3 years). Through CFA the already five-factor structure of the TES-A (Anticipation of trauma, Intrusion, Avoidance, Resignation, Hyperstimulation) was applied to our sample. All five factors were significantly and positively correlated with each other. All Cronbach’s alpha were over 0.7, indicating acceptable reliability of the factors. Relatively convergent validity, all factors of the Greek version of the TES-A were significantly associated with stress, anxiety, depression and coping strategies.ConclusionThe Greek version of TES-A is detected to be a valid and reliable instrument of prenatal Posttraumatic Stress Disorder (PTSD) symptomatology among low-risk Greek pregnant women.
New “iPARKO” finger extensor facilitation training device for chronic hemiplegic hand after stroke: development and verification of its effectiveness in healthy individuals
Authors: Nakamura Ai , Peichen Zhou , Morita Yoshifumi , Tanabe Hirofumi 
Published: April 2023

AbstractAfter stroke, hemiplegic individuals have difficulty opening their hands by themselves due to paralysis. A finger extensor facilitation technique was therefore developed to increase the activity of the extensor muscle in hemiplegic individuals who cannot open their paralyzed hands by themselves. In our previous study, we created a training device prototype called the “PARKO”, that imitates the finger extensor facilitation technique; however, the activity of the extensor muscle using the device was much smaller than that of the finger extensor facilitation technique. In this study, we developed a new finger extensor facilitation training device, the “iPARKO”, to increase the activity of the extensor muscle during active training. We thus improved the structure of the PARKO device—including a modified method to apply force to the fingertips—and attached force sensors to the device to monitor these forces. To verify the effectiveness of the iPARKO device, we conducted active training using the device in healthy individuals. Comparing the results of the muscle activities between the PARKO and iPARKO devices among three healthy participants demonstrated that the iPARKO device increased the mean activity of the extensor muscle by 43.8%. Furthermore, the activity of the extensor muscle in two healthy individuals while moving the hand forward with the iPARKO device was 84% and 96% of the maximal voluntary contraction during the hand-opening motion without the iPARKO device.
Children's attitudes towards aging people-validation of an instrument
Authors: Fernandes Carla Sílvia Neves da Nova , Moreira Teresa , Galvão Joana 
Published: April 2023

Abstract
Purpose
It is essential to develop and improve instruments that measure and assess children's attitudes towards the elderly. Despite the degree of questions related to this topic, no tools validated for the Portuguese population on the subject were found in the literature. Consequently, this study aimed to translate and validate a scale designed to assess children’s attitudes towards the elderly (Todaro Scale) for the Portuguese population.

Design and methods
The method recommended by the literature for psychometric validation and evaluation of instruments was followed. In the conception of the study, the following stages were followed: translation of the ‘‘Todaro Scale’’, translation and back-translation by an independent translator, validation by an expert panel, pre-test and validation of the questionnaire, and testing the scale measurement properties. The convenience sample comprised 60 children between the ages of 4 and 6, of Portuguese nationality and residents of Portugal.

Results
The results obtained in the reliability and validity tests reveal a good internal consistency. The 14 items of the scale, and after the use of principal component analysis, there were grouped into five dimensions: social participation, personality characteristics; Health and Safety, physical and instrumental; cognitive and social appreciation.

Conclusions
The psychometric study confirms that the ‘‘Galvão Scale: children’s attitudes towards the elderly’’ includes the essential indicators and dimensions to ensure an adequate assessment of children’s attitudes towards the elderly. Practice implications: we believe this research could become an indispensable contribution to analysing, monitoring, and intervening to demystify existing ageing stereotypes.
The phylogenetic relationship among two species of genus Nebo (Scorpiones: Diplocentridae) from Saudi Arabia and Middle East
Authors: Alqahtani Abdulaziz R. , Alotaibi Noura J. , Aly Hamdy , Badry Ahmed 
Published: April 2023

Abstract
Background
The genus Nebo has been identified as a medically important scorpion species distributed across Arabia and the Middle East. However, its taxonomic status remains unclear.

Aim
The molecular phylogeny of two Nebo species from Saudi Arabia and comparative sequences from Palestine is presented based on the mitochondrial cytochrome oxidase subunit I (COI) gene.

Methodology
Scorpion specimens were collected from two different localities, mainly the Southern part of Saudi Arabia. Then, DNA was extracted, amplified using invertebrate universal primers, and sequenced to identify the COI gene. The obtained sequences were analyzed, and phylogenetic trees based on maximum parsimony, neighbor-joining, and Bayesian inference were constructed.

Results
The inferred phylogeny indicates the monophyletic status of the family Diplocentridae and its subfamily Nebinae and Diplocentrinae. Also, the phylogenetic analyses support the existence of interspecific and intraspecific variations among/ within Nebo hierichonticus and Nebo yemenensis which may indicate distinct species.

Conclusion
Further morphological studies with additional specimens from the Arabian Peninsula may reveal possible undiscovered and cryptic species.
Patients as research partners in preference studies: learnings from IMI-PREFER
Authors: Smith Meredith Y. , Janssens Rosanne , Jimenez-Moreno A. Cecilia , Cleemput Irina , Muller Mireille , Oliveri Serena , Simons Gwenda , Strammiello Valentina , Huys Isabelle , Falahee Marie 
Published: April 2023

Abstract
Background
There is growing recognition of the importance of patient and public stakeholder involvement (PPI) in patient preference research. However, limited evidence exists regarding the impact, barriers and enablers of PPI in preference studies. The Innovative Medicines Initiative (IMI)-PREFER project conducted a series of preference case studies which incorporated PPI.

Objective
To describe: (1) how PPI was operationalized in the PREFER case studies, (2) the impact of PPI, and (3) factors that served to impede and facilitate PPI.

Methods
We reviewed the PREFER final study reports to determine how patient partners were involved. We conducted a thematic framework analysis to characterize the impact of PPI and then administered a questionnaire to the PREFER study leads to identify barriers and facilitators to effective PPI.

Results
Eight PREFER case studies involved patients as research partners. Patient partners were involved in activities spanning all phases of the patient preference research process, including in study design, conduct and dissemination. However, the type and degree of patient partner involvement varied considerably. Positive impacts of PPI included improvements in the: (1) quality of the research and research process; (2) patient partner empowerment; (3) study transparency and dissemination of results; (4) research ethics, and (5) trust and respect between the research team and the patient community. Of the 13 barriers identified, the 3 most frequently reported were inadequate resources, insufficient time to fully involve patient partners, and uncertainty regarding how to operationalize the role of ‘patient partner. Among the 12 facilitators identified, the two most frequently cited were (1) having a clearly stated purpose for involving patients as research partners; and (2) having multiple patient partners involved in the study.

Conclusion
PPI had many positive impacts on the PREFER studies. Preference study leads with prior PPI experience reported a greater number of positive impacts than those with no such experience. In light of the numerous barriers identified, multi-faceted implementation strategies should be considered to support adoption, integration and sustainment of PPI within preference research. Additional case studies of patient partner involvement in preference research are needed as well to inform best practices in this area.
Association of C-reactive protein with histological, elastographic, and sonographic indices of non-alcoholic fatty liver disease in individuals with severe obesity
Authors: Jamialahmadi Tannaz , Bo Simona , Abbasifard Mitra , Sathyapalan Thozhukat , Jangjoo Ali , Moallem Seyed Adel , Almahmeed Wael , Ashari Sorour , Johnston Thomas P. , Sahebkar Amirhossein 
Published: April 2023

Abstract
Background
Inflammation is critical in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). hs-CRP, an inflammatory marker, is considered one of the prognostic predictors of hepatic damage progression in NAFLD in some studies.

Methods
We assessed the concordance of hs-CRP concentrations and liver steatosis, steatohepatitis, and fibrosis based on elastography, sonography and liver biopsy findings in patients with severe obesity undergoing bariatric surgery.

Results
Among 90 patients, 56.7% showed steatohepatitis and 8.9% severe fibrosis. Hs-CRP were significantly associated with liver histology in an adjusted regression model (OR 1.155, 95% CI 1.029–1.297, p = 0.014; OR 1.155, 1.029–1.297, p = 0.014; OR 1.130, 1.017–1.257, p = 0.024 for steatosis, steatohepatitis, and fibrosis, respectively). The ROC curve, a cutoff of hs-CRP = 7 mg/L, showed a reasonable specificity (76%) for detecting biopsy-proven fibrosis and steatosis.

Conclusion
hs-CRP was associated with any degree of histologically diagnosed liver damage, and it had a reasonable specificity for predicting biopsy-proven steatosis and fibrosis in obese individuals. Further studies are needed to identify non-invasive biomarkers that could predict NALFD progression due to the relevant health risks linked to liver fibrosis.
Detection of false data injection attacks on power systems using graph edge-conditioned convolutional networks
Authors: Chen Bairen , Wu Q. H. , Li Mengshi , Xiahou Kaishun 
Published: April 2023

AbstractState estimation plays a vital role in the stable operation of modern power systems, but it is vulnerable to cyber attacks. False data injection attacks (FDIA), one of the most common cyber attacks, can tamper with measurement data and bypass the bad data detection (BDD) mechanism, leading to incorrect results of power system state estimation (PSSE). This paper presents a detection framework of FDIA for PSSE based on graph edge-conditioned convolutional networks (GECCN), which use topology information, node features and edge features. Through deep graph architecture, the correlation of sample data is effectively mined to establish the mapping relationship between the estimated values of measurements and the actual states of power systems. In addition, the edge-conditioned convolution operation allows processing data sets with different graph structures. Case studies are undertaken on the IEEE 14-bus system under different attack intensities and degrees to evaluate the performance of GECCN. Simulation results show that GECCN has better detection performance than convolutional neural networks, deep neural networks and support vector machine. Moreover, the satisfactory detection performance obtained with the data sets of the IEEE 14-bus, 30-bus and 118-bus systems verifies the effective scalability of GECCN.
Role of osteoprotegerin rs3102735 gene polymorphism in acute ischemic stroke patients
Authors: Monir Dina , Osama Ahmed , Saad Alaa Eldin , Negm Mohamed , Abd El-Razek Reda 
Published: April 2023

Abstract
Background
Ischemic stroke ranks third among leading causes of death and disability. Both endothelial and vascular smooth muscle cells generate osteoprotegerin (OPG). Ischemic stroke and its severity may be enhanced by the OPG rs3102735 gene polymorphism. Our research aims to investigate OPG rs3102735 gene polymorphism role in ischemic stroke risk and to assess its association with stroke severity at presentation and degree of vascular stenosis and evaluate its potential as a predictor of stroke severity. Fifty people with acute ischemic stroke as well as fifty controls were studied. The NIHSS and ASPECTS were utilized to evaluate stroke severity and the infarction size, respectively. All subjects underwent extracranial carotid duplex study and molecular assessment for genotyping of OPG rs3102735) gene polymorphism.

Results
Stroke patients had markedly higher concentrations of OPG in the plasma than controls (311.60 ± 109.48 versus 240.20 ± 75.96 mmol/ml, p = 0.001). The optimal plasma OPG cutoff value for the predicting the occurrence of stroke was determined to be > 250 mmol/ml, the 95% confidence interval (CI) was (0.625–0.843), sensitivity was 68% and specificity was 72%. Ischemic stroke had a significantly different genotype distribution for the OPG rs3102735 gene polymorphism than did controls (36 CC, 13 CT, and 1 TT) versus (28 CC, 15 CT, and 7 TT) respectively. Stroke patients had a significantly greater CC + CT genotype than controls did (P = 0.041), also they had a higher propensity for carrying the C allele than the T allele (P = 0.017). Carotid intima medium thickness and the NIHSS both had positive correlations with OPG serum level (r = 0.39, p = 0.02 and r = 0.4, p = 0.02, respectively), whereas ASPECTS had an inversed correlation (r = − 0.65, p = 0.001).

Conclusions
The current study shows that as an independent risk factor, increased plasma OPG level, may participate in the atherothrombotic ischemic stroke pathophysiology, in addition, genetic variants in the OPG gene (rs3102735) are a separate risk factor for large artery atherosclerosis and plasma OPG level can serve as a biomarker to determine the severity of a stroke.