bluuebunny/crossref_metadata_2025_split huggingface dataset:
Non-osteopenic Bone Pathology After Allo-hematopoietic Stem Cell Transplantation in Patients with Inborn Errors of Immunity
Authors: Golwala Zainab M. , Bhat Nikita Gireesh , Xu-Bayford Jinhua , Stankova Tanja , Adams Stuart , Morris Emma C. , Qasim Waseem , Booth Claire , Worth Austen , Kusters Maaike A. , Elfeky Reem 
Published: March 2023

Abstract
Purpose
There is a lack of data on post-HSCT non-osteopenic bone pathology specifically for children with inborn errors of immunity (IEI). We collected data on non-osteopenic bone pathology in children with IEI post-HSCT over two decades in a large tertiary pediatric immunology center.

Methods
Descriptive study with data analysis of bone pathology in allo-HSCT for IEI was performed between 1/1/2000 to 31/12/2018 including patients alive at follow-up to July 2022. Records were analyzed for bone pathology and risk factors. Exclusion criteria included isolated reduced bone density, fractures, and skeletal anomalies due to underlying IEI and short stature without other bone pathology. Bone pathologies were divided into 5 categories: bone tumors; skeletal dysplasia; avascular necrosis; evolving bone deformities; slipped upper femoral epiphysis.

Results
A total of 429 children received HSCT between 2000 and 2018; 340 are alive at last assessment. Non-osteopenic bone pathology was observed post-HSCT in 9.4% of patients (32/340, mean 7.8 years post-HSCT). Eleven patients (34%) had > 1 category of bone pathology. Seventeen patients (17/32; 53%) presented with bilateral bone pathology. The majority of patients received treosulfan-based conditioning (26/32; 81.2%). Totally, 65.6% (21/32) of patients had a history of prolonged steroid use (> 6 months). Pain was the presenting symptom in 66% of patients, and surgical intervention was required in 43.7%. The highest incidence of bone pathologies was seen in Wiskott-Aldrich syndrome (WAS) (n = 8/34; 23.5%) followed by hemophagocytic lymphohistiocytosis patients (n = 3/16; 18.8%).

Conclusion
Non-osteopenic bone pathology in long-term survivors of allo-HSCT for IEI is not rare. Most patients did not present with complaints until at least 5 years post-HSCT highlighting the need for ongoing bone health assessment for patients with IEI. Children presenting with stunted growth and bone pathology post-HSCT should undergo skeletal survey to rule out development of post-HSCT skeletal dysplasia. Increased rates and complexity of bone pathology were seen amongst patients with Wiskott-Aldrich syndrome.
Housing adequacy in an informal built environment: case studies from Ahmedabad
Authors: Marnane Kali , Greenop Kelly 
Published: March 2023

AbstractInformal settlement is a spatial manifestation of inequality, in that people turn to informal solutions for housing when formal ones are out of reach, usually because of financial constraints but also other factors such as social exclusion. However very little is known about the architectural and urban forms that constitute informal settlements, and thus how this inequality manifests spatially, and what specifically is inadequate in these settlements is not currently well understood. We use the framework of the United Nations Right to Adequate Housing as a benchmark to determine whether housing is contributing to inequality through one or more failures of adequacy, in which case we define these as being inequitable housing. We analyse the architecture of four cases within three informal settlements in Ahmedabad, Gujarat state, India, to examine how these urban forms both reflect and/or remedy multi-scalar urban housing inequalities. Four key physical spaces are found to be important: the dwelling’s site, resident’s control over dwelling design and construction, the design of the dwelling threshold, and the characteristics of shared open spaces. In the right combination, the quality of these physical spaces in informal settlements can contribute to informal settlement residents achieving housing adequacy. A better understanding of the built environment of informal settlements can enable designers and planners to harness the potential of informal settlement environments that are assets of the urban poor, create a context that stops informal settlements becoming ‘slum-like’ and help construct pathways towards urban equality.
Impacts of anthropogenic pressures on underwater light conditions and diatom functional group distributions in mountain lakes
Authors: Atti Sanna , Rantala Marttiina V. , Lami Andrea , Meyer-Jacob Carsten , Smol John P. , Weckström Jan , Nevalainen Liisa 
Published: March 2023

AbstractUnderwater light availability and exposure of ultraviolet radiation (UV) in mountain lakes is mainly controlled by dissolved organic matter and ice cover. However, both of these factors are affected by climate warming and other anthropogenic pressures. Still, little is known of the impacts of long-term fluctuations in underwater light conditions onto functional distribution of diatoms, species sensitive to changes in climate and UV penetration in mountain lakes. Two mountain lakes in the Italian Alps were analysed using paleolimnological approaches to investigate impacts of anthropogenic pressures (e.g., climate warming, acidification) on underwater light availability, exposure to UV and diatom functional group distributions, focusing on the post-industrial era. Contemporary diatom communities were collected from the main habitats in the shallow, high irradiance littoral zones of these lakes and geochemical proxies describing the development of lake-water transparency and carbon dynamics were analyzed from the sediment cores covering the time period from ca. 1400 CE to present. The geochemical data indicate that cultural acidification decreased lake-water organic carbon concentrations in both lakes, which suggests increased light availability and UV exposure during the past century. The responses of the studied lakes to anthropogenic pressures varied, as the lake situated at a lower altitude with a larger catchment showed only a few biotic changes indicating higher resilience, whereas the lake situated at higher altitude showed distinct changes in its ecological status. In this alpine lake, almost 30% of the diatom functional groups shifted from benthic to planktic during the post-industrial era. The role of increased light availability and UV exposure as a driver of diatom functional group distributions could not be unambiguously separated, and such diatom assemblage changes have been shown in many regions and most closely linked to a warming climate. However, low guild functional groups, prevalent also in the contemporary samples from the shallow littoral zone, dominated the diatom communities throughout the studied period, suggesting high tolerance to UV radiation.
Religious and Medical Pluralism Among Traditional Healers in Johannesburg, South Africa
Authors: Galvin Michael , Chiwaye Lesley , Moolla Aneesa 
Published: March 2023

AbstractReligion and spirituality are powerful social forces in contemporary South Africa. Traditional Health Practitioners (THPs) are commonly consulted for both spiritual and medical ailments as a first line of care. Many studies have assessed African traditional health seeking behaviors but few have examined beliefs, practices, and behaviors of THPs themselves. This study sought to explore spiritual worldviews among South African THPs. Semi-structured in-depth interviews were conducted with 18 THPs in Johannesburg, South Africa between January and May, 2022. Interviews were transcribed and translated into English. Data were managed using NVivo 12 software and thematically analyzed. The majority of THPs interviewed indicated that initiation as a THP was almost always preceded by a sickness accompanied by dreams/visions that represented an “ancestral calling” to become a healer. Most THPs also trained as both sangomas—who healed according to traditional beliefs—and prophets—who healed according to Christian beliefs. This reflects a syncretic relationship between traditional African beliefs and Christianity. However, not all churches are accepting of traditional beliefs and subsequently these THPs are members only at non-Pentecostal AIC churches who blend both African and Christian practices. Similar to these forms of religious pluralism melding Christianity and traditional beliefs, many THPs also often practice medical pluralism, mixing Western treatments with traditional practices/medicines. THPs are able to adapt elements of Western and African beliefs into healing practices that span multiple religious and medical fields. Thus, collaborative and decentralized healthcare services may be highly acceptable among such a pluralistic community.
Relative effects of urbanisation, deforestation, and agricultural development on mosquito communities
Authors: Perrin Antoine , Schaffner Francis , Christe Philippe , Glaizot Olivier 
Published: March 2023

AbstractContextDespite numerous studies that showed negative effects of landscape anthropisation on species abundance and diversity, the relative effects of urbanisation, deforestation, and agricultural development as well as the spatial extent at which they act are much less studied. This is particularly the case for mosquitoes, which are the most important arthropods affecting human health.ObjectivesWe determined the scale of effect of these three landscape anthropisation components on mosquito abundance and diversity. We then assessed which landscape variables had the most effect as well as their independent positive or negative effects.MethodsWe used mosquito data collected by Schaffner and Mathis (2013) in 16 sampling sites in Switzerland. We measured forest, urban and agricultural amounts in 485 concentric landscapes (from 150 to 5000 m radius) around each sampling site. We then identified the spatial extent at which each landscape metric best predicted abundance and diversity of mosquito species and compared the effect size of each landscape component on each response variable.ResultsIn Switzerland, urbanisation and deforestation have a greater influence on mosquito diversity than agricultural development, and do not act at the same scale. Conversely, the scale of effect on mosquito abundance is relatively similar across the different landscape anthropisation components or across mosquito species, except forCulex pipiens. However, the effect size of each landscape component varies according to mosquito species.ConclusionThe scale of management must be selected according to the conservation concern. In addition, a multi-scale approach is recommended for effective mosquito community management.
Prognostic significance of the genetic variant of lymphotoxin alpha (p.Thr60Asn) in egyptian patients with advanced hepatocellular carcinoma
Authors: Alhelf Maha , Shoaib Rasha M. S. , Elsaid Afaf , Bastawy Nermeen , Elbeltagy Nanis S. , Salem Eman T. , Refaat Sherif , Abuelnadar Eman H. 
Published: March 2023

Abstract
Background
Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide in terms of mortality, and susceptibility is attributed to genetic, lifestyle, and environmental factors. Lymphotoxin alpha (LTA) has a crucial role in communicating the lymphocytes with stromal cells and provoking cytotoxic effects on the cancer cells. There are no reports on the contribution of the LTA (c.179 C>A; p.Thr60Asn; rs1041981) gene polymorphism to HCC susceptibility. The main aim of this study is to investigate the association of LTA (c.179 C>A; p.Thr60Asn; rs1041981) variant with the HCC risk in the Egyptian population.

Methods
This case-control study included 317 participants (111 HCC patients, and 206 healthy controls). The LTA (c.179 C>A; p.Thr60Asn; rs1041981) polymorphism was assessed by tetra-primer amplification refractory mutation system polymerase chain reaction (T-ARMS-PCR) technique.

Results
The frequencies of the dominant and recessive models (CA + AA; AA) of the LTA (c.179 C>A; p.Thr60Asn; rs1041981) variant were statistically significant among HCC patients in comparison to controls (p = 0.01; p = 0.007; respectively). The A-allele of LTA (c.179 C>A; p.Thr60Asn; rs1041981) variant was statistically significant in HCC patients in comparison to controls (p ˂ 0.001).

Conclusion
The LTA (c.179 C>A; p.Thr60Asn; rs1041981) polymorphism was independently associated with an increased risk for hepatocellular carcinoma in the Egyptian population.
3D Static Modeling and CO2 Static Storage Estimation of the Hydrocarbon-Depleted Charis Reservoir, Bredasdorp Basin, South Africa
Authors: Afolayan Blessing Ayotomiwa , Mackay Eric , Opuwari Mimonitu 
Published: March 2023

AbstractAn essential greenhouse gas effect mitigation technology is carbon capture, utilization and storage, with carbon dioxide (CO2) injection into underground geological formations as a core of carbon sequestration. Developing a robust 3D static model of the formation of interest for CO2 storage is paramount to deduce its facies changes and petrophysical properties. This study investigates a depleted oilfield reservoir within the Bredasdorp Basin, offshore South Africa. It is a sandstone reservoir with effective porosity mean of 13.92% and dominant permeability values of 100–560 mD (1 mD = 9.869233 × 10–16 m2). The petrophysical properties are facies controlled, as the southwestern area with siltstone and shale facies has reduced porosity and permeability. The volume of shale model shows that the reservoir is composed of clean sands, and water saturation is 10–90%, hence suitable for CO2 storage based on petrophysical characteristics. Static storage capacity of the reservoir as virgin aquifer and virgin oilfield estimates sequestration of 0.71 Mt (million tons) and 1.62 Mt of CO2, respectively. Sensitivity studies showed reservoir depletion at bubble point pressure increased storage capacity more than twice the depletion at initial reservoir pressure. Reservoir pressure below bubble point with the presence of gas cap also increased storage capacity markedly.
A Novel Vision Transformer Model for Skin Cancer Classification
Authors: Yang Guang , Luo Suhuai , Greer Peter 
Published: March 2023

AbstractSkin cancer can be fatal if it is found to be malignant. Modern diagnosis of skin cancer heavily relies on visual inspection through clinical screening, dermoscopy, or histopathological examinations. However, due to similarity among cancer types, it is usually challenging to identify the type of skin cancer, especially at its early stages. Deep learning techniques have been developed over the last few years and have achieved success in helping to improve the accuracy of diagnosis and classification. However, the latest deep learning algorithms still do not provide ideal classification accuracy. To further improve the performance of classification accuracy, this paper presents a novel method of classifying skin cancer in clinical skin images. The method consists of four blocks. First, class rebalancing is applied to the images of seven skin cancer types for better classification performance. Second, an image is preprocessed by being split into patches of the same size and then flattened into a series of tokens. Third, a transformer encoder is used to process the flattened patches. The transformer encoder consists of N identical layers with each layer containing two sublayers. Sublayer one is a multihead self-attention unit, and sublayer two is a fully connected feed-forward network unit. For each of the two sublayers, a normalization operation is applied to its input, and a residual connection of its input and its output is calculated. Finally, a classification block is implemented after the transformer encoder. The block consists of a flattened layer and a dense layer with batch normalization. Transfer learning is implemented to build the whole network, where the ImageNet dataset is used to pretrain the network and the HAM10000 dataset is used to fine-tune the network. Experiments have shown that the method has achieved a classification accuracy of 94.1%, outperforming the current state-of-the-art model IRv2 with soft attention on the same training and testing datasets. On the Edinburgh DERMOFIT dataset also, the method has better performance compared with baseline models.
Comparison of Cognitive Intervention Strategies for Individuals With Alzheimer’s Disease: A Systematic Review and Network Meta-analysis
Authors: Xiang Chunchen , Zhang Yumei 
Published: March 2023

AbstractAccumulating evidence has shown the effectiveness of cognitive interventions, which can be divided into cognitive training (CT), cognitive stimulation (CS), cognitive rehabilitation (CR), and combined interventions (i.e., cognitive interventions combined with other non-pharmacological interventions such as physical exercise), in individuals with Alzheimer’s disease (AD). However, the effectiveness of cognitive interventions varies greatly among studies and more comprehensive studies are required. We aimed to evaluate whether the current evidence shows that cognitive interventions are effective at improving cognition, neuropsychiatric symptoms, depression, quality of life, and basic activities of daily living among individuals with possible or probable AD. Randomized controlled trials of all types of cognitive intervention were identified for inclusion in pairwise and network meta-analyses. There was a moderate and statistically significant post-intervention improvement in global cognition among individuals with AD for all types of cognitive intervention compared to control interventions (39 studies, g = 0.43, 95% CI: 0.28 to 0.58, p < 0.01; Q = 102.27, df = 38, p < 0.01; I2 = 61.97%, τ2 = 0.13). Regarding the specific types of cognitive intervention, combined interventions had the highest surface under the cumulative ranking curve (SUCRA) value (90.7%), followed by CT (67.8%), CS (53.4%), and lastly CR (28.9%). Significant effects of cognitive interventions were also found for working memory, verbal memory, verbal fluency, confrontation naming, attention, neuropsychiatric symptoms, basic activities of daily living, and quality of life.
Optical strain sensor with dual fibre Bragg grating topology
Authors: Palmowski Jacek , Barczak Kamil , Kubicka Natalia , Gołek Franek , Benson Luke , Maciak Erwin , Pustelny Tadeusz , Phang Sendy , Benson Trevor , Bereś-Pawlik Elżbieta 
Published: March 2023

AbstractThe paper presents the design, operation, and proof of principle realisation and validation of a relatively cheap fibre optic strain sensor based on two fibre Bragg grating (FBG) elements with different spectral responses. Its performance is compared with the measurement capabilities of a FBG-based sensor that uses an optical interrogator.
Exploring options for increasing maize yields and grain Zn concentrations in sub-Saharan Africa
Authors: Breure Mirjam S. , Njoroge Samuel , Pasley Heather R. , Hoffland Ellis 
Published: March 2023

Abstract
Background
Increasing zinc (Zn) concentrations in maize grains could contribute to alleviating widespread human Zn deficiency in sub-Saharan Africa (SSA). However, trade-offs between grain Zn concentrations and maize yields have been observed.

Scope
Using data from researcher-managed, on-farm and on-station field trials in Kenya, Zambia and Zimbabwe, we aimed (i) to confirm whether this trade-off is found in current farming systems in SSA and (ii) to explore whether genotypic and management options, relevant for the African context, can increase both yields and grain Zn concentrations across several environments.

Results
An overall negative, but weak relation between maize yields and grain Zn concentrations was found. High yields and high grain Zn concentrations did not co-occur. The negative relation between grain Zn concentrations and yields cannot be bypassed by selecting one of the commercially available varieties used in this study. Nitrogen application increased yields, but had contrasting effects on grain Zn concentrations depending on variety and site. Grain Zn concentrations were positively related with soil organic carbon and P and K availability.

Conclusions
Attaining grain Zn concentrations above the HarvestPlus target of 38 mg kg−1, considered adequate for reducing human Zn deficiency, with current commercially available maize varieties and presented management options, is not possible without compromising yield levels. Increasing soil organic matter content and balanced application of N, P and K fertilisers could increase grain Zn concentrations. These practices likely will also increase yields and could be a viable option to bypass the trade-off between maize yields and grain Zn concentrations.
Integrated Morphological, Physiological and Molecular Analysis of the Drought Response in Cultivated and Wild Prunus L. Subgenera Cerasus Species
Authors: Jalili Sara , Arzani Kazem , Prudencio Angela S. , Salazar Juan A. , Martínez-García Pedro J. , Bouzari Naser , Martínez-Gómez Pedro 
Published: March 2023

AbstractKnowledge about the genetic potential of wild Prunus species is important for recognizing gene pools in germplasm and developing effective strategies for germplasm conservation and breeding. In this study, cultivated sweet cherry (Prunus avium L.) and relative wild Cereus subgenus genotypes belonging to P. microcarpa Boiss and P. incana (Pall.) Batsch. species were assayed in controlled drought conditions performing an integrated morphological, physiological, genomic and transcriptomic analysis of the stress response. These analyses were performed under well-watered and water-deficient conditions analysing morphology of leaves, gas exchange parameters and chlorophyll content differently affected by drought, especially under long-term water deficiency. From a genomic point of view, these genotypes were characterized using simple sequence repeat (SSR) markers. Finally, in the analysis of the transcriptional responses, drought tolerance candidate genes were analysed by quantitative PCR (qPCR). From a morphological point of view, P. microcarpa showed less leaf area, height and diameter in comparison to P. incana and mainly P. avium. The highest rate of photosynthesis in genotypes differently was observed in the control treatment and the lowest rate viewed during stress. The analysed genes showed different responses to drought in the genotypes, and more detailed analysis techniques to explain the molecular mechanisms of drought tolerance are needed in these genotypes. Our results provide a significant contribution to the understanding of how P. incana and P. microcarpa respond to drought stress, which may help to explain molecular and physiological mechanisms associated with the response to the drought of cherries. Additionally, these results show that wild cherries can be considered as a genetic source of drought resistance in breeding programs.