bluuebunny/crossref_metadata_2025_split huggingface dataset:
A novel inhibitor of the mitochondrial respiratory complex I with uncoupling properties exerts potent antitumor activity
Authors: Cordier-Bussat Martine , ASSI Alaa AL , POSTY Solène , Lamarche Frédéric , CHEBEL Amel , Guitton Jérôme , PRUDENT Renaud , LAFANECHERE Laurence , GIRAUD Stéphane , DALLEMAGNE Patrick , Suzanne Peggy , GENESTIER Laurent , Castets Marie , Fontaine Eric , Billaud Marc 
Published: July 2023

Abstract

Cancer cells are highly reliant on bioenergetic processes to support their growth and survival. Disrupting these metabolic pathways, notably by targeting the electron transport chain complexes (ETC-I to V) in the mitochondrial bioenergetic hub, has become an attractive therapeutic strategy. As a result, the pursuit of identifying clinically effective new inhibitors of the respiratory chain with minimized adverse effects stands as a significant objective. Here, we characterize a first in class OXPHOS inhibitor compound called MS-L6, which behaves as an inhibitor of ETC-I, combining inhibition of NADH oxidation and decoupling effect. MS-L6 is effective on both intact and fragmented mitochondrial membranes, indicating that its efficacy does not rely on its accumulation within the mitochondria. MS-L6 reduces ATP synthesis and induces a metabolic shift with increased glucose consumption and lactate production in cancer cell lines, while having minimal effects on primary hepatocytes. Its dose-dependently inhibits cell proliferation or induces cell death in a wide range of cancer cell lines, including B-cell and T-cell lymphoma, as well as pediatric sarcoma. Furthermore, ectopic expression of Saccharomyces cerevisiae NADH-dehydrogenase NDI1 partially restores the viability of lymphoma B cells treated with MS-L6, demonstrating that inhibition of NADH oxidation is key for its antitumoral activity. Finally, MS-L6 administration induces a robust inhibition of lymphoma tumor growth in two murine xenograft models, without significant toxicity. Therefore, our data unveil MS-L6 as an inhibitor of oxidative phosphorylation (OXPHOS), with an unexpected dual mechanism of action on the respiratory chain. Additionally, MS-L6 demonstrates potent antitumoral properties in preclinical models, positioning it as the pioneering member of a promising new drug class to be assessed for cancer therapy.
Covid-19 Progress in Patients With Familial Mediterranean Fever
Authors: Demir Bilgehan , karahan doğu 
Published: July 2023

Abstract
Background
Familial Mediterranean Fever (FMF) is a genetic auto-inflammatory disease. Mutations in the MEFV gene cause inappropriate immune system triggering, leading to inflammatory episodes in the peritoneum, pleura, and joints. In the severe COVID-19 picture, the hyperimmune response and inflammatory process develop and the clinic worsens. The FMF disease, the drugs used for its treatment, and the situation that different genetic mutations will display in the course of COVID-19 arouse interest.
Methods
In this study, common and different points in COVID-19 follow-up processes were evaluated by online questionnaire method according to different gene mutations in 158 FMF patients who had gene analysis. Participants were asked 21 questions and the data provided were compared between FMF MEFV gene mutations
Results
104 out of 158 cases did not get COVID-19. 8 of 54 cases who get COVID-19 were hospitalized. No statistically significant difference was found between gene mutations when evaluated and compared in terms of susceptibility to COVID-19, vaccination status and presence of additional chronic diseases.
Conclusion
The present study provides guidance on the role of FMF genetic mutations in the course of COVID-19. Our study may suggest that FMF MEFV gene mutations do not have a protective role against COVID-19. The results also suggest that, as an inverse effect, MEFV gene mutations do not increase the risk of hyper-immune response and SARS, which play a role in the severe course of COVID-19.
Psychrophiles to Control Ice-Water Phase Changes in Frost-Susceptible Soils
Authors: Rahman Rashed , Bheemasetti Tejo V. , Govil Tanvi , Sani Rajesh 
Published: July 2023

Abstract
The phase changes of soil water or porous media have a crucial influence on the performance of natural and man-made infrastructures in cold regions. Several treatment methods to mitigate the effects of frost action have been studied earlier, but traditional methods often rely on chemicals, physical techniques, and the reuse of waste materials, which often have limitations. However, certain organisms produce ice-binding proteins (IBPs) or antifreeze proteins (AFPs) to adapt to low temperatures, which can inhibit ice crystal growth by lowering the freezing point and preventing ice crystallization without the need for external intervention. This study explores the potential of three psychrophilic microbes: Sporosarcina psychrophile, Sporosarcina globispora, and Polaromonas hydrogenivorans, to induce non-equilibrium freezing point depression and thermal hysteresis in order to control ice lens growth in frost-susceptible soils. The growth profiles of the microbes, the concentration of released proteins in the extracellular solution, and the thermal properties of the protein-mixed soils are monitored at an interval of three days. The controlled soil showed a freezing point of -4.59 0C and thermal hysteresis of 4.62 0C, whereas protein-treated soil showed a maximum freezing point depression of -8.54 0C and thermal hysteresis of 7.71 0C. Interestingly, except for the controlled sample, all the protein-treated soil samples were thawed at a negative temperature (minimum recorded at -0.85 0C). Further analysis showed that the treated soils compared to porous media mixed soil freeze (1.25 0C vs. 0.51 0C) and thaw (2.75 0C vs. 1.72 0C) at extensive temperature gap. Overall, this study presents a novel bio-mediated approach using psychrophilic microbes to control ice formation in frost-susceptible soils.
Tumor-resident microbiota contributes to colorectal cancer liver metastasis by lactylation and immune modulation
Authors: Lu Ling , Gu Jian , Xu Xiaozhang , Yue Lei , Zhu Xiaowen , Chen Qiuyang , Gao Ji , Takashi Maruyama , Zhao Wenhu , Zhao Bo , Zhang Yue , Zhou Jinren , Liang Yuan , Pan Yufeng , Li Xiangyu , Shao Qing , Li Yu , Wang Yiming , Xu Zibo , Qian Qufei , Huang Tianning , Qian Xiaofeng 
Published: July 2023

Abstract
The role of tumor-resident microbiota in modulating tumor immunity remains unclear. Here, we discovered an abundance of intra-tumoral bacteria, such us E.coli, residing and resulting in Colorectal cancer liver metastasis (CRLM). E.coli enhanced lactate production, which mediated M2 macrophage polarization by suppressing nuclear factor-κB -gene binding (NF-κB) signaling through retinoic acid-inducible gene 1 (RIG-I) lactylation. Lactylation of RIG-I suppressed recruitment of NF-κB to the Nlrp3 promoter in macrophages, thereby reducing its transcription. This loss of Nlrp3 affected the antitumor activities of regulatory T cells (Tregs) and CD8+ T cells. Small-molecule compound screening identified a RIG-I lactylation inhibitor that suppressed M2 polarization and sensitized CRLM to 5-fluorouracil (5-FU). Our findings suggest that tumor-resident microbiota may be a potential target for preventing and treating CRLM.
Multiple Applications of a Novel Fluorescence Probe with Large Stokes Shift and Sensitivity for Rapid H2S Detection
Authors: Hong Laixin , Sun Le , Li Cong , Zhang Ronglan , Zhao Jianshe 
Published: July 2023

Abstract
Herein, a novel fluorescence probe Fla-DNP based on flavonol has been designed and synthesized for rapid, specific detection of H2S. With the addition of H2S, Fla-DNP triggered thiolysis and released Fla displaying the “turn-on” NIR fluorescence response at 566 nm, which is consistent with the reaction site predicted by calculating Electrostatic potential and ADCH charges. As an easily available H2S probe, Fla-DNP has the advantages of high selectivity, anti-interference, low detection limit (0.834 µM), short response time (6 min), and large Stokes shift (124 nm). The sensing mechanism of H2S was determined by HRMS analysis and DFT calculation. Moreover, Fla-DNP can detect H2S in environmental water samples with good recovery rates of 89.6%-102.0% and be made into fluorescence test strips to track the H2S produced during foodstuff spoilage to determine the freshness. Meanwhile, the probe exhibits good biocompatibility and can not only be available used for H2S detection in living cells but be further designed as an H2S-activated CO photoreleaser, based on which to develop its potential as an anti-cancer drug.
In Silico Analysis of SOS Family in Areca palm (Areca catechu. L)
Authors: alam Osama , asmat sobia 
Published: July 2023

Abstract
The salt-overly sensitive ( SOS) gene is a signaling gene that helps plants to respond to high salinity stress. It is activated when cells are exposed to high levels of sodium ions, and it leads to a number of changes in gene expression that help the plant cope with high salinity stress. However, The SOS gene in Arecha palm has not been studied, despite being present in various plant species. We have identified 10 members of the AcatSOS family of genes, which are dispersed randomly over 5 chromosomes in the genome of Areca catechu. Using the phylogenetic analysis of 10 AcatSOS genes and two additional species rice and Arabidopsis—the tree is divided into 5 subfamilies: Group 1, Group 2, Group 3, Group 4 and Group 5. Each gene in the AcatSOS family was identified on its physiochemical properties. The plastid and vacuole contain most of the localization signals. Furthermore, there were numerous cis-acting areas and light-responsive elements in the promoter sequences of the AcatSOS genes. After the Areca palm genome was sequenced, segmental and tendom duplications were discovered, providing evidence of a major driving force in the evolution of the AcatSOS gene family. Areca palms share numerous genes, in terms of orthologous relationships, with other monocotyledonous plants because of their evolutionary affinity and related heritage. The development of the leaf, endocarp, and epicarp is regulated by the AcatSOS genes, according to circular heat. AcatSOS-4, AcatSOS-6 and AcatSOS-8 are highly regulated in plants. Genome-wide characterization of the SOS gene expression patterns has revealed that the expression of these genes is regulated in a complex manner. It is influenced by several factors, including the level of salinity stress, the developmental stage of the plant, and the tissue type.
Petrogenesis and Tectonic Evolution of the Kahnouj Ophiolitic Complex (SE Iran): Constraints from geochemistry and Sr-Nd-Pb isotope composition
Authors: Siani Majid Ghasemi , Mehrabi Behzad , Yang Huai-Jen , Neubauer Franz , Huang Kuo-Fang , Liu Yung-Hsin 
Published: July 2023

Abstract
Based on new Sr-Nd-Pb isotope-compositional and lithogeochemical data combined with previously published data of the Kahnouj ophiolite, we propose a tectonic model for the Kahnouj ophiolitic complex. The Kahnouj ophiolitic complex is the largest ophiolite of the Makran zone and consists of isotropic and layered gabbros with ultramafic lenses at the bottom and sheeted dikes, and basalts and pelagic limestones on the top. A cyclic succession of isotropic and layered gabbros indicates a distinct differentiation trend of early clinopyroxene crystallization followed by hornblende. Crystal fractionation and partial melting processes are also inferred by Nd isotopic and whole-rock geochemical data (e.g., fractionation recorded by the Al2O3/TiO2 versus Ti/1000 diagram). Geochemically, the gabbros are subalkaline and show tholeiitic features. The εNd values of + 7 to + 7.6 and initial 87Sr/86Sr ratios of 0.70352 to 0.70377 indicate a mid-ocean ridge mantle source for the gabbroic rocks. The whole rock geochemistry of the layered and isotropic gabbros suggest that they formed in a back-arc basin setting and represent MOR- to supra-subduction type ophiolites in the Neotethys Ocean during Jurassic to Early Cretaceous (156 to 121 Ma).
Blood Pressure Measurements for Diagnosing Hypertension in Primary Care: Room for Improvement
Authors: Voorbrood V.M.I. , de Schepper E.I.T. , Bohnen A.M. , Ruiterkamp M.F.E. , Bindels P. J.E. , Rijnbeek P.R. 
Published: July 2023

Abstract
Background
In the adult population, about 50% have hypertension, a risk factor for cardiovascular disease and subsequent premature death. Little is known about the quality of the methods used to diagnose hypertension in primary care.
Objectives
The objective was to assess the completeness of the method of systolic blood pressure measurements that were used to diagnose patients with new-onset hypertension and to assess the correct interpretation of the blood pressure level.
Methods
A population-based cohort study using electronic medical records of patients in primary care aged between 40 and 70 years with a new-onset of hypertension in the years 2012, 2016, 2019, and 2020. A visual chart review of the electronic medical records was used to assess the methods employed to diagnose hypertension in a random sample of 500 patients. The blood pressure measurement method was considered complete if three or more valid office blood pressure measurements (OBPM) were performed, or home-based blood pressure measurements (HBPM), the office- based 30-minute method (OBP30), or 24-hour ambulatory blood pressure measurements (24H-ABPM) were used.
Results
In all study years, OBPM was the most frequently used method to diagnose new-onset hypertension in patients. The OBP-30 method was used in 0.4% (2012), 4.2% (2016), 10.6% (2019), and 9.8% (2020) of patients respectively, 24H-ABPM in 16.0%, 22.2%, 17.2%, and 19.0% of patients and HBPM measurements in 5.4%, 8.4%, 7.6%, and 7.8% of patients, respectively. A diagnosis of hypertension based on only one or two office measurements occurred in 85.2% (2012), 87.9% (2016), 94.4% (2019), and 96.8% (2020) of all patients with OBPM. In cases of incomplete measurement and incorrect interpretation, medication was still started in 64% of cases in 2012, 56% (2016), 60% (2019), and 73% (2020).
Conclusion
OBPM is still the most often used method to diagnose hypertension in primary care. The diagnosis was often incomplete or misinterpreted using incorrect cut-off levels. A small improvement occurred between 2012 and 2016 but no further progress was seen in 2019 or 2020. If hypertension is inappropriately diagnosed, it may result in under treatment or in prolonged, unnecessary treatment of patients. There is room for improvement.
The linear convergence rate of the linearized version of alternating direction method of multipliers for convex optimization with three separable functions
Authors: Li Meishu , Lu Zhenrong , Ma Yang 
Published: July 2023

Abstract
The linearized alternating direction methods of multipliers (L-ADMM) for solving convex minimization problems with two separable blocks in the objective functions is efficient. And its extended version (\(m \geqslant 3\)) is convergent under some mild conditions. Recently, The L-ADMM inspires much attention in analyzing its theoretical convergence rate. However, the research on its convergence rate is still in its infancy. In this paper, we consider the convergence rate of L-ADMM when solving the convex optimization problems that the subdifferentials of the underlying functions are piecewise linear multifunctions. Based on the error bound, we establish the linear convergence rate.
Extrauterine Growth Restriction and Catch-up Growth Following NICU Discharge: a Tale of two Standards
Authors: Olgun Lena , Weintraub Andrea , Green Robert 
Published: July 2023

Abstract
Objectives:
To assess extrauterine growth restriction (EUGR) after neonatal intensive care unit (NICU) discharge and identify factors associated with catch-up growth (CUG) and neurodevelopmental outcomes at age 2.
Study Design:
Growth parameters at birth, 36 weeks postmenstrual age (PMA), and two neurodevelopmental follow-up visits were reviewed retrospectively. EUGR was assessed using Fenton and Intergrowth-21 standards. Factors associated with outpatient growth and neurodevelopmental outcomes at age 2 were evaluated using logistic and linear regression.
Results:
369 infants comprised the cohort. EUGR prevalence was 14.9% for Intergrowth-21 vs. 56.4% for Fenton (p < 0.001). There was a significant decrease in weight z-score from birth-36 weeks PMA. Weight z-scores returned to birth values by the 2nd clinic visit. Formula-fed infants had faster CUG. Higher Bayley-III at age 2 were associated with human milk feeding.
Conclusions:
Fewer infants were EUGR using Intergrowth-21. CUG with return to birth weight z-score was seen. Human milk feeding positively impacted Bayley-III scores, despite slower CUG.
MTMR7 suppresses the phenotypic switching of vascular smooth muscle cell and vascular intimal hyperplasia after injury via regulating p62/mTORC1-mediated glucose metabolism
Authors: Sun Xiongshan , Yang Yao , Zhao Weiwei , Wang Mingliang , Chen Yingmei , Wang Jia , Yang Dachun , Yang Yongjian 
Published: July 2023

Abstract

Myotubularin-related protein 7 (MTMR7) suppresses the proliferation in various of cell types and is also associated with vascular stenosis-related disease. However, whether MTMR7 regulates the vascular smooth muscle cell (VSMC) and vascular intimal hyperplasia remains unclear. We aimed at exploring the role of MTMR7 in the phenotypic switching of VSMC and vascular intimal hyperplasia after injury. MTMR7 expression was significantly downregulated in injured artery. Compared to wild type (WT) mice, Mtmr7-transgenic (Mtmr7-Tg) mice showed reduced intima/media ratio, decreased percentage of Ki-67-positive cells within neointima, and increased Calponin expression in injured artery. Upregulating MTMR7 by Len-Mtmr7 transfection inhibited platelet derived growth factor (PDGF)-BB-induced proliferation, migration of VSMCs and reversed the decrease in expression of Calponin and SM-MHC. Microarray, single cell sequence, and other bioinformatics analysis revealed that MTMR7 is highly related to glucose metabolism and mammalian target of rapamycin complex 1 (mTORC1). Further experiments confirmed that MTMR7 markedly repressed glycolysis and mTORC1 activity in PDGF-BB-challenged VSMC. Restoring mTORC1 activity abolished MTMR7-mediated suppression of glycolysis, phenotypic shift in VSMC and protection against vascular intimal hyperplasia. Furthermore, upregulating MTMR7 led to dephosphorylation and dissociation of p62 from mTORC1. External expression of p62 also abrogated the inhibitory effects of MTMR7 on glycolysis and phenotypic switching in PDGF-BB-stimulated VSMC. Our study demonstrates that MTMR7 inhibits injury-induced vascular intimal hyperplasia and phenotypic switching of VSMC. Mechanistically, the beneficial effects of MTMR7 are conducted via suppressing p62/mTORC1-mediated glycolysis.
Probe-based confocal laser endomicroscopy for real-time evaluation of colorectal liver metastasis in resected surgical specimens
Authors: Takao Mikiya , Kawaguchi Yoshikuni , Matsumura Masaru , Kazami Yusuke , Tanimoto Meguri , Abe Satoru , Maki Harufumi , Ishizawa Takeaki , Arita Junichi , Akamatsu Nobuhisa , Kaneko Junichi , Kokudo Norihiro , Hasegawa Kiyoshi 
Published: July 2023

Abstract
Background
Probe-based confocal laser endomicroscopy (pCLE) enables real-time examination of tissue structure. This study investigated pCLE with or without fluorescein sodium for the intraoperative diagnosis of colorectal liver metastasis (CLM) and detection of surgical margins.
Methods
Thirty-four specimens of CLM and adjacent noncancerous tissue were obtained from 21 patients and examined by pCLE between May 2017 and March 2018. Images were obtained both without and with fluorescein sodium applied to the cut surface and compared with hematoxylin and eosin-stained tissue. Fluorescence intensity (FI) was measured by luminance-analysis software.
Results
Without external fluorophores, pCLE visualized 91.2% of CLM tissues as an irregular structure with low autofluorescence and 90.5% of noncancerous liver tissues as a regular structure with high autofluorescence. The median FI was significantly lower in cancer than in benign tissue in patients without chemotherapy [70.4 (51.6–110) vs. 48.3 (39.0–59.4), p = 0.002] and with chemotherapy [67.9 (54.6–89.2) vs. 48.6 (28.8–82.1), p < 0.001]. The border was clearly visible; pCLE with fluorescein sodium clearly showed their morphologies.
Conclusion
Real-time pCLE distinguished CLM and noncancerous tissue by differences in structure and FI regardless of prehepatectomy chemotherapy. Fluorescein spray facilitated clear visualization of differences in the morphology.
Efficient stereo matching using the weighted polygon window and the HSV color space
Authors: Guan Haijiao , Xiaoye Wang , An Aimin , Lei Ye , Wang Runmin 
Published: July 2023

Abstract

To solve the problem of low matching accuracy of existing binocular stereo vision in discontinuous disparity and low texture area, a robust stereo matching method is proposed in this paper, including improved Census transform and improved AD algorithm. The improvements of the Census transform are twofold: Firstly, a method that uses the Euclidean distance between pixels to formulate Hamming distance weights is proposed better to reflect the influence of surrounding pixels on the center pixel; Secondly, a new alternative algorithm for the center pixel is proposed to effectively reduce the problem of over-reliance of the result on the center pixel in the traditional Census transform. In addition, AD cost volume is calculated in the HSV color space and combined with the Census cost volume obtained using the improved Census transform. The result is aggregated by Weighted Guided Filter and then the cost is optimized by multi-step post-processing. The experimental results show that the proposed algorithm in this paper can effectively reduce the mismatching rate, the disparity map obtained has less noise, and the matching effect is better under different illumination and noise conditions.
Optimal parameter of the SOR-like iteration method for solving absolute value equations
Authors: Chen Cairong , Huang Bo , Yu Dongmei , Han Deren 
Published: July 2023

Abstract
The SOR-like iteration method for solvingthe system of absolute value equations~(AVE) of finding a vector $x$ such that $Ax - |x| - b = 0$ with $\nu = \|A^{-1}\|_2 < 1$ is investigated. The convergence conditions of the SOR-like iteration method proposed by Ke and Ma ([{\em Appl. Math. Comput.}, 311:195--202, 2017]) are revisited and a new proof is given, which exhibits some insights in determining the convergent region and the optimal iteration parameter. Along this line, the optimal parameter which minimizes $\|T_\nu(\omega)\|_2$ with$$T_\nu(\omega) = \left(\begin{array}{cc} |1-\omega| & \omega^2\nu \\ |1-\omega| & |1-\omega| +\omega^2\nu \end{array}\right)$$and the approximate optimal parameter which minimizes an upper bound of $\|T_\nu(\omega)\|_2$are explored. The optimal and approximate optimal parameters are iteration-independent and the bigger value of $\nu$ is, the smaller convergent region of the iteration parameter $\omega$ is. Numerical results are presented to demonstrate that the SOR-like iteration method with the optimal parameter is superior to that with the approximate optimal parameter proposed by Guo, Wu and Li ([{\em Appl. Math. Lett.}, 97:107--113, 2019]).