bluuebunny/crossref_metadata_2025_split huggingface dataset:
Strategi Music Director Radio Elgangga 100,3Fm Bekasi Dalam Mempertahankan Minat Pendengar
Authors: Prasetyo Dwiki Haris , Fikry Yasser 
Published: March 2023

Penelitian ini dilakukan untuk mengetahui strategi seorang Music Director Radio Elgangga dalam mempertahankan minat pendengar. Dalam penelitian ini, peneliti menggunakan pendekatan penelitian kualitatif dan Teknik pengumpulan data untuk penelitian ini menggunakandilakukan dengan wawancara yang mendalam. Wawancara dilakukan dengan 3 informan yaitu Music Director sebagai key informan, Produser sebagai informan 1 (satu) dan Penyiar sebagai informan 2 (dua). Hasil dari penelitian ini menunjukan bahwa pentingnya sebuah strategi yang dilakukan oleh music director terhadap mempertahankan minat pendengarnya. Dengan memutarkan lagu lagu yang hits yang disukai oleh pendengarnya serta menerima dan memutarkan lagu dari requestan dari pendengar adalah salah satu strategi yang dimiliki oleh music director radio Elgangga.Kata Kunci : Strategi Music Director, Radio Elgangga, Mempertahankan Minat Pendengar
Pengaruh Influencer Media Sosial terhadap Brand Image Erigo
Authors: Pantouw Dominique Theodora Virginia , Kurnia Kurnia 
Published: March 2023

Public Relations menggunakan media sosial sebagai salah satu strategi komunikasi. Dalam penelitian ini, dibahas secara spesifik tentang strategi komunikasi Public Relations yang melibatkan peran Influencer Media Sosial dalam mengoptimalkan keberhasilan komunikasinya dalam meningkatkan Brand Image. Penelitian ini memiliki tujuan untuk meneliti pengaruh penggunaan InfluencerMedia Sosial terhadap Brand Image melalui studi kasus pada Brand Fashion Lokal Erigo. Metode yang digunakan dalam penelitian ini adalah pendekatan kuantitatif dengan menggunakan Teknik Sampling jenis Convenience Sampling. Populasi penelitian adalah konsumen Erigo dengan kriteria konsumen Erigo yang memiliki media sosial dan menggunakannya secara aktif juga mengikuti akun media sosial Instagram Erigo. Ditetapkan jumlah responden menggunakan rumus Lemeshow sebanyak 100 sampel. Data dikumpulkan dengan menggunakan survei online dan dianalisis menggunakan metode Partial Least Square (PLS). Hasil penelitian ini menunjukan bahwa Influencer Media Sosial berpengaruh positif terhadap Brand Image. Hasil penelitian juga menunjukan bahwa dengan mengoptimalkan Influencer Media Sosial sebagai sarana komunikasi yang memiliki Visibility, Credibility, Attractiveness, dan Power akan meningkatkan Brand Image. Berdasarkan temuan tersebut maka Local Clothing Brand Erigo harus tetap memaksimalkan strategi komunikasi media sosial dengan melibatkan Influencer Media Sosial yang mempunyai nilai Visibility, Credibility, Attractiveness, dan Power untuk memperkuat Brand Image-nya sebagai Global Clothing Brand yang dapat bersaing dengan Global Clothing Brand lainnya.
Medición de parámetros de signos vitales para emisión de alertas móviles
Authors: Torres-Pardo Ingrid Durley , Guzmán-Luna Jaime A. , Barros-Ligan Carlo Mario , Gutiérrez-López Juan Pablo 
Published: March 2023

Una preocupación en las personas, consiste en cómo conocer su inmediato estado de salud. Un indicador clave para ello, lo reportan los parámetros de signos vitales: temperatura, frecuencia cardíaca y oxigenación; Los dispositivos wearables, permiten ese monitoreo mediante conexión con un móvil; sin embargo, muchos usuarios desconocen o no logran la interpretación adecuada de tales reportes. Por esta razón, además de monitorear automáticamente los signos vitales (en periodos determinados de tiempo), el objetivo del sistema propuesto, consiste en emitir alertas que se envían automáticamente, no solo al usuario del dispositivo, sino también a un acompañante mediante mensaje de texto, cada vez que alguno de estos parámetros se encuentra fuera del rango normal permitido. Esto se logra con un modelo de categorización de usuarios soportado por un sistema de reglas que describe los rangos normales, estableciendo criterios para emitir las alertas. El beneficio principal del sistema propuesto, es tener información específica y en tiempo real, de un parámetro corporal permitiendo advertir un estado alterado de salud, insumo importante, para tomar decisiones médicas.
Abstract, one of the main concerns of people, is how to know their immediate state of health. A key indicator for this is reported by vital signs parameters such as temperature, heart rate and oxygenation; The wearable devices, allow such monitoring by connecting to a cell phone; however, many users are unaware or fail to achieve the proper interpretation of such reports. For this reason, in addition to monitoring vital signs, the objective of this proposed system is to issue alerts that are sent automatically, not only to the user of the device, but also to a companion via text message whenever any of these parameters is outside the normal allowed range. This is achieved with a user categorization model supported by a system of rules that describes the normal allowed ranges, establishing criteria for issuing alerts. The main benefit of the proposed system is to have specific information in real time, of a body parameter that allows warning of an altered state of health, which is useful as information for making medical decisions.
Influencia del método de secado (horno con convección vs horno microondas), sobre la composición nutricional de diferentes forrajes
Authors: Gutiérrez-León Francisco , Artos-García Richard Bladimir , Portilla-Narvaez Arnulfo Rigoberto 
Published: March 2023

La alimentación es el costo más importante en la producción animal. El objetivo de esta investigación fue comparar los métodos de secado en diferentes forrajes para la obtención de materia seca, horno con convección de aire (HC) y horno microondas (HM), y su efecto sobre la composición nutricional de cada forraje. Se estudiaron seis forrajes comúnmente utilizados en la producción animal: maíz duro amarillo (MA) (Zea mays), pasta de soya (PS) (Glycine max L.), rechazo de verde (RV) (Musa × paradisiaca), ensilaje de maíz (EM) , alfalfa (AL) (Medicago sativa) y raigrás perenne (RP) (Lolium perenne). Se analizaron 40 muestras de cada forraje, cada forraje fue secado en HC, así como en HM y se estimó el contenido de materia seca (MS), luego se le realizó un análisis bromatológico; Proteína bruta (Pb), extracto etéreo (EE), fibra bruta (Fb) y cenizas. Se utilizaron un análisis de varianza y prueba de Tukey (p<0.05) para determinar diferencias entre medias. Los resultados demuestran que existen diferencias (p<0.05) en el contenido de (MS), siendo el HM quien alcanza un mayor nivel de MS en MA, PS, RV y AL, el RP tuvo valores más altos con el HC mientras que en el EM el contenido de MS no varía con los métodos de secado. Los métodos de secado tuvieron incidencia en la composición química de los forrajes, así por ejemplo de los 6 forrajes analizados en la Pb se observó diferencias en 5, Fb en 3, EE en 1 y cenizas en 4.
Livestock feeding is the most important cost in animal production. The objective of this research is to compare the drying methods on different forages for obtaining dried matter, convection oven (CO) and microwave oven (MO), and the effect of each method on the nutritional composition of each forage. Six types of forages, commonly used in animal production, were studied: yellow hard corn (YC) (Zea mays), soybean paste (SP) (Glycine max L.), banana reject (BR) (Musa × paradisiaca), corn silage (CS), alfalfa (AL) (Medicago sativa) and perenial ryegrass (PR) (Lolium perenne). 40 samples of each forage were analized, each forage was dried using CO and MO, and the dried matter content was estimated, then a bromatological analysis was done. Crude protein (Cp), ethereal extract (EE), crude fiber (Cf) and ashes. A variance analysis and tukey test (p<0.05) were used to determine differences between means. Results show that differences (p<0.05) exist in the content of DM, being that MO reaches the highest level of DM in YC, SP, BR and AL, the PR had higher values with the CO while in the CS the content of DM does not vary with the drying methods. The drying methods had incidence on the chemical composition of forages, for example of the six forages analized in the Cp differences were observed in 5, Cf in 3, EE in 1 and ashes in 4.
A co-delivery system based on chlorin e6-loaded ROS-sensitive polymeric prodrug with self-amplified drug release to enhance the efficacy of combination therapy for breast tumor cells
Authors: Wang Cui , Yang Xiaoqing , Qiu Haibao , Huang Kexin , Xu Qin , Zhou Bin , Zhang Lulu , Zhou Man , Yi Xiaoqing 
Published: March 2023

Background: Recently, various combination therapies for tumors have garnered popularity because of their synergistic effects in improving therapeutic efficacy and reducing side effects. However, incomplete intracellular drug release and a single method of combining drugs are inadequate to achieve the desired therapeutic effect.Methods: A reactive oxygen species (ROS)-sensitive co-delivery micelle (Ce6@PTP/DP). It was a photosensitizer and a ROS-sensitive paclitaxel (PTX) prodrug for synergistic chemo-photodynamic therapy. Micelles size and surface potential were measured. In vitro drug release, cytotoxicity and apoptosis were investigated.Results: Ce6@PTP/DP prodrug micelles exhibited good colloidal stability and biocompatibility, high PTX and Ce6 loading contents of 21.7% and 7.38%, respectively. Upon light irradiation, Ce6@PTP/DP micelles endocytosed by tumor cells can generate sufficient ROS, not only leading to photodynamic therapy and the inhibition of tumor cell proliferation, but also triggering locoregional PTX release by cleaving the thioketal (TK) bridged bond between PTX and methoxyl poly (ethylene glycol). Furthermore, compared with single drug-loaded micelles, the light-triggered Ce6@PTP/DP micelles exhibited self-amplified drug release and significantly greater inhibition of HeLa cell growth.Conclusion: The results support that PTX and Ce6 in Ce6@PTP/DP micelles exhibited synergistic effects on cell-growth inhibition. Thus, Ce6@PTP/DP micelles represent an alternative for realizing synergistic chemo-photodynamic therapy.
Chilean institutional policies and multi-level agents: Challenges from the COVID-19 pandemic and carbon footprint
Authors: Bergamini Kay , Ojeda Carolina G. , Gutiérrez Patricia , Salazar Gonzalo , Curillán Christian 
Published: March 2023

IntroductionAs a result of the increasing number of multilateral agreements that Chile has signed, different sectors of consumption have become sources of emissions. In this context attempts to implement guidelines to address this issue have been made. Nevertheless, international policies such as sustainable development goals (SDG) 11–12 often generate dissonance in national and local administrations and have been approached by different instruments to reduce the effects of emissions, mostly focused on the private industrial sector.MethodsThis article focuses on four of the most polluted cities in south-central Chile (Coronel, Temuco, Valdivia, and Osorno). Key agents (ministries, regional government, municipalities, and civil society) from three levels of policy development were selected at three scales (national, regional, and local) and interviewed considering three thematic axes: knowledge of carbon footprint areas (housing, heating, food, mobility, and energy), institutional governance, and adaptive changes due to COVID-19.ResultsThe results show that in Chile, there is a multiscale climate governance led by the Ministry of the Environment (national level), followed by the regional and local levels. Citizens are then left with few capacities, which is negatively viewed. In relation to the carbon footprint and COVID-19, it can be observed that the topic of energy was more addressed at the national and regional levels. Food and energy, followed by heating and then mobility were addressed at the communal level and in civil society.DiscussionDecision-making strategies and policies were discussed in this paper.
Grades 7–12 teachers' perception of computational thinking for mathematics and technology
Authors: Humble Niklas , Mozelius Peter 
Published: March 2023

IntroductionAn ongoing trend on a global scale is the integration of computer science and programming in K-12 education. The integration has been motivated by the needs of the present and future labor market but also by the assumption that skills related to computer science and programming are valuable for citizens to navigate an increasingly digitalized society. Computational thinking (CT) is a concept that aims to define and summarize skills associated with programming and computer science and has received wide recognition within research and education. But how do the teachers perceive this concept, and how do they relate it to their own teaching and learning activities? This study aims to investigate and discuss teachers' perceptions of CT in grades 7–12 mathematics and technology.MethodsData have been collected from essay assignments in three instances of a professional development course on fundamental programming for grades 7–12 teachers in mathematics and technology. In the essays, the teachers reflect on CT in relation to mathematics and technology and teaching and learning activities in these subjects. With a theoretical framework for CT, the collected data have been analyzed with a directed content analysis approach to identify categories of interests for CT in relation to grades 7–12 mathematics and technology.ResultsThe results of the study show that the teachers perceive both opportunities and challenges in applying the CT concept in their teaching and learning activities. For example, it can strengthen the subjects through new practices and reinforce old practices, but it could be too complex and perceived as difficult by some students. Furthermore, many of the teachers perceive CT not only to be relevant for mathematics and technology but also for learning in general.DiscussionThe conclusion of the study is that CT has the potential to enhance teaching and learning activities in mathematics, technology, and other STEM subjects. If this should be successful, CT must not be involved too abstractly or too superficially. This study contributes to the discussion on CT in K-12 education, adding the teachers' perspective. The findings of this study can be used by teachers and other stakeholders in the design of classroom activities that apply the CT concept.
Relationship between bone mineral density and hyperuricemia in obesity: A cross-sectional study
Authors: Zhang Yi , Tan Min , Liu Boyu , Zeng Manxia , Zhou You , Zhang Mengru , Wang Yikai , Wu Jing , Wang Min 
Published: March 2023

BackgroundObesity is an increasingly severe global public health issue. This study aims to estimate the cross-sectional association between bone mineral density (BMD) and hyperuricemia (HU) in obesity.MethodA total of 275 obese subjects (126 men and 149 women) participated in this cross-sectional study. Obesity was diagnosed as body mass index (BMI) ≥28 kg/m2, whereas HU was defined as the blood uric acid level of 416 μmol/L in men and 360 μmol/L in women. The BMD of the lumbar spine and right hip was measured by dual-energy X-ray absorptiometry (DXA). The multivariable logistic regressions were employed to examine the relationship between BMD and HU in obesity, with the adjustment of gender, age, fasting blood glucose, fasting insulin, homeostasis model assessment of insulin resistance (HOMA-IR), cholesterol, triglycerides, low-density lipoprotein, high-density lipoprotein, creatinine, blood urea nitrogen, high-sensitivity C-reactive protein (hs-CRP), cigarette smoking, and alcohol drinking status.ResultThe overall prevalence of HU was 66.9% in this obese population. The mean age and BMI of this population were 27.9 ± 9.9 years and 35.2 ± 5.2 kg/m2, respectively. The multivariable-adjusted OR (the highest vs. lowest BMD quartile) demonstrated a negative relationship between BMD and HU in total (OR = 0.415, 95%CI: 0.182–0.946; p = 0.036), L1 (OR = 0.305, 95%CI: 0.127–0.730; p = 0.008), L2 (OR = 0.405, 95%CI: 0.177–0.925; p = 0.032), and L3 (OR = 0.368, 95%CI: 0.159–0.851; p = 0.020) lumbar vertebrae. In the subgroup analysis for the male population, the BMD was also negatively associated with HU in total (OR = 0.077, 95%CI: 0.014–0.427; p = 0.003), L1 (OR = 0.019, 95%CI: 0.002–0.206; p = 0.001), L2 (OR = 0.161, 95%CI: 0.034–0.767; p = 0.022), L3 (OR = 0.186, 95%CI: 0.041–0.858; p = 0.031), and L4 (OR = 0.231, 95%CI: 0.056–0.948; p = 0.042) lumbar vertebrae. However, such findings did not exist in women. In addition, there was no significant relationship between hip BMD and HU in obesity.ConclusionOur results showed that the lumbar BMD was negatively associated with HU in obesity. However, such findings only existed in men, rather than women. In addition, no significant relationship between hip BMD and HU existed in obesity. Due to the limited sample size and nature of the cross-sectional design, further large prospective studies are still needed to clarify the issues.
The regulatory effects of p53 on the typical and atypical ferroptosis in the pathogenesis of osteosarcoma: A systematic review
Authors: Wang Linfeng , Pan Su 
Published: March 2023

Study background: As a rare condition, osteosarcoma affects approximately 3% of all cancer patients. Its exact pathogenesis remains largely unclear. The role of p53 in up- and down-regulating atypical and typical ferroptosis in osteosarcoma remains unclear. The primary objective of the present study is investigating the role of p53 in regulating typical and atypical ferroptosis in osteosarcoma.Methods: The Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) and the Patient, Intervention, Comparison, Outcome, and Studies (PICOS) protocol were used in the initial search. The literature search was performed in six electronic databases, including EMBASE, Cochrane library of trials, Web of Science, PubMed, Google Scholar, and Scopus Review, using keywords connected by Boolean operators. We focused on studies that adequately defined patient profiles described by PICOS.Results and discussion: We found that p53 played fundamental up- and down-regulatory roles in typical and atypical ferroptosis, resulting in either advancement or suppression of tumorigenesis, respectively. Direct and indirect activation or inactivation of p53 downregulated its regulatory roles in ferroptosis in osteosarcoma. Enhanced tumorigenesis was attributed to the expression of genes associated with osteosarcoma development. Modulation of target genes and protein interactions, especially SLC7A11, resulted in enhanced tumorigenesis.Conclusion: Typical and atypical ferroptosis in osteosarcoma were regulatory functions of p53. The activation of MDM2 inactivated p53, leading to the downregulation of atypical ferroptosis, whereas activation of p53 upregulated typical ferroptosis. Further studies should be performed on the regulatory roles of p53 to unmask its possible clinical applications in the management of osteosarcoma.
Utilization of a novel 3D radiologic scoring method to define therapeutic response and surgical candidacy
Authors: Rahmanuddin Syed , Von Hoff Daniel D. , Chaudhry Ammar , Guidaben Danielle , Khan Marjaan , Boswell William , Cridebring Derek , Brase Jordyn , Fong Yuman , Motarjem Pejman , Borazanci Erkut 
Published: March 2023

PurposeNeoadjuvant therapy and surgical resection can improve the survival rate of patients who receive a diagnosis of pancreatic cancer and shows to be potentially curative. The aim of this study is to define a novel CT perfusion analytical method by observing the treatment response of pancreatic cancer patients in a neoadjuvant-treated population to determine surgical candidacy.Experimental designThis prospective study involved 22 adult patients with pancreatic ductal adenocarcinoma (PDAC). Participants received neoadjuvant therapy (paricalcitol, paclitaxel protein-bound, cisplatin, and gemcitabine) for up to 6 months. The study examined differences in density between the arterial and venous phases of CT scans using a mathematical analysis called the Marley equation. The data was used to assess treatment responses and determined whether a patient can become a surgical candidate. The consideration for surgical candidacy was defined by Dr. Rahmanuddin, termed the “R” score and graphically depicted as the “R” Clock. The R score determined the number of tumor-linked blood vessels. Any vessel associated with tumor involvement received a score of 1. Patients who received a score of 5 or less were eligible for surgery. 3D Tumor volumetric analyses were performed using GE AW 3D software to assess the treatment response associated with tumor perfusion.ResultsVisual differences in vascular involvement between baseline and final imaging were associated with a higher likelihood of proceeding to surgery. After administration of the neoadjuvant therapy, 81% of patients (18 of 22) received an R score of 5 or less, deeming all of them eligible for surgery. A total of 59% of patients (13 of 22) proceeded with the surgery. Changes in arterial and venous perfusion reflected tumor aggressiveness as defined by the Marley equation.ConclusionCT vessel perfusion using the R score and Marley Equation might be helpful in defining the surgical candidacy of PDAC patients when used in conjunction with 3D tumor volumetric quantification. The parameters defined by the R score determined higher perfusion scores as having greater vascular growth, and patients with tumor involvement of more than six vessels were deemed surgically unresectable. The Marley equation demonstrated tumor aggression via changes in arterial and venous perfusion. Additional studies are needed to further validate these methodologies and assess their clinical utility.
Runoff from upstream changes the structure and energy flow of food web in estuary
Authors: Yi Yujun , Zhao Fanxuan , Liu Qi , Song Jie 
Published: March 2023

IntroductionSediment and nutrients flow into estuary with runoff, and then influence the estuary ecosystem. Much work has been done for investigating the response of water quality and species group (eg. phytoplankton or zooplankton) to the runoff from upstream, while few research has been taken to evaluate the response of the whole ecosystem.MethodsFood webs of different seasons and regions were established based on stable isotope analysis and Bayesian mixing model. The influences of upstream runoff and sediment transport on the estuarine food webs were analyzed.ResultsFood web in estuary had highly spatial-temporal variability. The stable isotope values of organisms were higher on the northern shore than that on the southern shore. The area with high-turbidity freshwater inflow nurtured more terrestrial- organic- matter (TOM) relying species. And the contribution of TOM to food web was higher in flood season than that in non-flood season. The trophic levels of major consumers in the non-flood season were generally higher than that in the flood season. Significant differences in the average TP of species between two shores appeared during the non-flood season (P &lt; 0.05). Expect for the C value, all of the topological indexes of food webs on the northern shore were higher than those on the southern shore, and they were higher in the flood period.DiscussionThe input and diffusion of sediment and nutrients carried by runoff led to the changes in the dietary structure of estuarine organisms and the decrease in trophic levels of major consumers. At the same time, flow pulse with high sediment also aggravated the spatial differences of the structure of food webs. The higher contribution of TOM to consumers increased the link density of food web on the southern shore, making it a more robust system. However, the high diversity of food sources and aquatic species made the food web more complex on the northern shore.