bluuebunny/crossref_metadata_2025_split huggingface dataset:
Experiencing China’s Intangible Cultural Heritage in Role-playing Games: Comparative Studies between MMORPGs and Larps
Authors: Liu Yuqiao 
Published: September 2023

In recent years, considerable attention has been devoted to preserving intangible cultural heritage (ICH) through games. From a combined game studies and heritage studies perspective, role-playing games (RPGs) have a unique advantage in that they immerse the player in a character to experience and understand the basics of culture in an engaging way. Among different types of role-playing games, live-action role-playing (larp) and massively multiplayer online role-playing games (MMORPGs) have a great potential to promote the learning of intangible cultural expressions and traditions that make them available to a wider public. In China, MMORPGs have had a positive impact on preserving China’s intangible heritage in virtual space and larps, specifically in the form of Jubensha, are also playing an important role in the same way.
The purpose of this study is to delve into how the ICH of China is being represented in MMORPGs and larps as an educational tool. With that target in mind, a close reading of selected MMORPG games -- A Dream of Jianghu and Justice Online -- and a larp game -- The Secret of the Gauze Lantern -- was conducted. The goals of this research are to understand what cultural experiences are integrated in those role-playing games to introduce Chinese ICH and explore the main differences between them in representing those intangible cultural elements. After analyzing these RPGs in-depth, I argue that both MMORPGs and larps show potential to safeguard the intangible cultural heritage of China; while MMORPGs present national-level intangible elements from different regions of China, Jubensha as a kind of larp focuses more on the indigenous traditions and customs of small-scale local areas.
Locating Method for Pick-up and Drop-off Spots for Shared Autonomous Vehicle-based Mobility Services
Authors: Silva Dahlen , Csiszár Csaba 
Published: September 2023

To provide safety to users and not disturb traffic flow, autonomous vehicles in shared on-demand mobility services cannot stop everywhere; thus, pick-up and drop-off (PUDO) spots must be dedicated or established for them. Our research objective is to propose a method to locate the PUDO spots for shared autonomous vehicle-based mobility services as this topic has been barely studied. The number of required PUDO spots is calculated, and the location is chosen considering the urban environment, walking radius, vehicle occupancy, and time for boarding and alighting among other parameters. Different from some methods applied to shared mobility, we consider the existing infrastructure (e.g., parking spaces) as potential locations for PUDO spots. The method is applied to a study case, demonstrating the applicability and providing the main findings: (i) the required number of PUDO spots decreases if willingness to walk increases; (ii) with a 3-min walking radius, 83% of curbside parking spaces can be repurposed, and 100% is reached with a 10-min walking radius; (iii) the minimum of 55% of curbside parking spaces can be repurposed with 10-min walking radius and without locating PUDO spots in private parking. Using our method, cities can determine the quantity of PUDO spots and their locations, being prepared in advance for the required changes in the existing infrastructure as well as the freed-up space to be repurposed.
A Systematic Review of Treatments for Mild Traumatic Brain Injury in Adults
Authors: Price James 
Published: September 2023

Context: Up to 15% of concussed patients experience persistent symptoms and functional impairment following injury. This is often related to headaches, dizziness, imbalance, and visual disturbances.
Objectives: To perform a systematic review of the evidence for interventions used to manage postconcussion symptoms in working-aged adults falling within the headache-migraine, ocular, and vestibular postconcussion symptom cluster subtypes.
Methods: A literature search was performed according to the PRISMA statement. PubMed, OVID, Cochrane Central, PEDro, OSTEMED, and the grey literature checklist were searched from the dates of creation of each database through December 29, 2020. The outcome measures were compared by generating the standardized mean difference (SMD) with 95% confidence intervals. GRADE (Grading of Recommendations, Assessment, Development and Evaluation) was used to rate the overall quality of the evidence.
Results: The literature search identified 496 candidate studies. After removing duplicates, 352 studies remained. The titles and abstracts of the remaining studies were screened for eligibility and 343 studies were excluded. The full text of the remaining nine studies was assessed for eligibility and risk of bias. None of these studies was excluded. This left nine studies for qualitative and quantitative analysis.
Conclusions: Moderate-quality evidence suggests 4 interventions show promise for treating adults with headache-migraine, ocular, and vestibular postconcussion subtype symptoms.
Uji Efektivitas Antibakteri Daun Tanaman Nusa Indah (Mussaenda pubescens ait. f ) Terhadap Bakteri Staphylococcus aureus ( Rosenbach )
Authors: Dwi Utari Priscilla , Darwis Welly , Sariyanti Mardhatillah 
Published: September 2023

Latar Belakang: penyakit infeksi sering dijumpai pada wilayah dengan cuaca panas, basah, serta status ekonomi yang rendah. Salah satu bakteri yang menyebabkan infeksis ialah Staphylococcus aureus. Antibioik eritromisin yang digunakan untuk mengobati infeksi memiliki berbagai efek samping. Pemanfaatan tanaman obat merupakan salah satu alternatif untuk mengatasi masalah tersebut. Daun tanaman nusa indah merupakan salah satu tanaman yang mempunyai banyak manfaat, salah satunya sebagai antibakteri. Penggunaan daun tersebut dengan cara menumbuk daun dan ditempelkan di bagain kulit yang terinfeksi, namun belum dilatar belakangi studi ilmiah.
Metode: Ekstraksi daun tanaman nusa indah sebelumnya dilakukan pengujian fitokima. Selanjutnya, dilakukan dengan metode maserasi menggunakan pelarut etanol 95% dan dilarutkan dengan akuades. Hasil ekstraksi kemudian dilakukan Uji Minimal Inhibitory Concentration (MIC). Setelah dilakukan uji MIC kemudian dilakukan pengujian efektivitas. Parameter yang digunakan ialah besarnya zona hambat yang terbentuk disekitar kertas cakram, dan Kontrol positif yang digunakan adalah larutan antibiotik Eritromisin 50 µg/ml untuk bakteri Staphylococcus aureus.
Hasil: Hasil pengujian fitokimia didapatkan metabolit sekunder positif ialah flavonoid, tanin, saponin, dan steroid. Hasil pengujian MIC didapatkan bahwa ekstrak daun tanaman nusa indah memiliki kemampuan sebagai antibakteri terhadap bakteri Staphylococcus aures. Dari analisis statistik pengujian ANOVA ekstrak daun tanaman nusa indah dalam menghambat bakteri Staphylococcus aureus memiliki nilai Fhitung > Ftabel dengan nilai α = 0,05 dan kemudian diuji lanjut dengan menggunakan uji Duncan dan didapatkan zona hambat yang efektif dalam menghambat Staphylococcus aureus yaitu pada konsentrasi 75% (E5).
Kesimpulan: Ekstrak daun tanaman nusa indah ( Mussaenda pubescens ait.f ) memiliki daya hambat terhadap pertumbuhn bakteri Staphylococcus aureus.
HUBUNGAN PERSEPSI MAHASISWA TERHADAP LINGKUNGAN PEMBELAJARAN DENGAN PRESTASI BELAJAR DI FAKULTAS KEDOKTERAN DAN ILMU KESEHATAN UNIVERSITAS BENGKULU
Authors: Woromboni Sarah , Ambarsarie Riry , Lestari Novriantika 
Published: September 2023

Latar Belakang : Hasil ujian atau prestasi akademik yang cenderung rendah dapat dipengaruhi oleh metode pembelajaran yang kurang tepat. Dalam rangka membantu mahasiswa mencapai tujuan pembelajaran maka institusi atau para pendidik dapat mengkombinasikan berbagai metode mengajar yang dapat merangsang mahasiswa terlibat aktif dalam pembelajaran. Evaluasi lingkungan pembelajaran dengan menggunakan kuesioner DREEM penting untuk peningkatan sarana dan pra sarana. Tujuan dari penelitian ini untuk mengetahui adanya hubungan persepsi lingkungan belajar dengan prestasi belajar pada mahasiswa di FKIK UNIB.
Metode : Penelitian ini menggunakan metode penelitian deskriptif-analitik dengan pendekatan studi cross sectional. Sampel penelitian adalah 177 orang mahasiswa angkatan 2017, 2018 dan 2019 yang aktif mengikuti kuliah di FKIK UNIB. Pengambilan sampel dilakukan dengan teknik total sampling menggunakan kuesioner Dundee Ready Educational Environment Measure (DREEM) dan data sekunder prestasi belajar berupa IPK didapat dari pihak akademik FK UNIB. Analisis Data menggunakan metode uji Pearson.
Hasil : Penelitian ini menunjukkan bahwa 138 (78,4 % ) mahasiswa di FKIK UNIB memiliki persepsi yang cenderung positif dengan performa akademik yang sedang. Persentase skor untuk persepsi akademik 21,89 (68,4%) secara signifikan lebih tinggi dari pada persepsi lingkungan sosial 16,42 (58,6%). Tidak terdapat hubungan yang signifikan antara persepsi lingkungan belajar dengan prestasi belajar dengan nilai uji p= 0,270 (p>0,5).
Kesimpulan: Penelitian menyimpulkan bahwa persepsi mahasiswa terhadap lingkungan belajar adalah positif. Namun masih ada beberapa area yang bermasalah sehingga perlu perhatian dan pertimbangan.
Kata Kunci : DREEM, Persepsi, Lingkungan Belajar, Prestasi Belajar
PERAN TINGKAT AKTIVITAS FISIK DALAM MEMPENGARUHI MASSA LEMAK VISCERAL PADA PASIEN DIABETES MELITUS TIPE 2: SUATU TINJAUAN KEPUSTAKAAN SISTEMATIK
Authors: Gracia Stevany , Ambarsarie Riry , Febrianti Ety 
Published: September 2023

Latar Belakang: Diabetes melitus (DM) merupakan penyakit gangguan metabolik akibat adanya kelainan pada proses sekresi insulin, kerja insulin, ataupun keduanya sehingga tubuh mengalami hiperglikemia kronis. Insulin dihubungkan dengan massa lemak viseral. Massa lemak viseral berkontribusi terhadap inflamasi, aterosklerosis, dislipidemia, dan hipertensi. Kurangnya aktivitas fisik pada pasien DM tipe 2 menyebabkan peningkatan risiko komplikasi. Penelitian ini bertujuan untuk mengeksplorasi peran aktivitas fisik terhadap massa lemak visceral pada pasien DM tipe 2.
Metode: Pencarian tinjauan bersumber pada PubMed dan Cochrane dengan kriteria dipublikasikan pada 2010-2020. Pengumpulan dan analisis data dilakukan dengan mengadopsi konsep Cook dan West. Penilaian kualitas kepustakaan dilakukan menggunakan tools The Central for Evidence-Based Medicine develops (CEBM). Hasil: Dari total 8.279 kepustakaan yang didapatkan, terdapat sebelas kepustakaan yang masuk ke dalam kriteria inklusi dan eksklusi. Sepuluh dari sebelas kepustakaan membahas pengaruh aktivitas fisik terhadap massa lemak visceral. Lima diantaranya menyatakan bahwa aktivitas fisik dengan intensitas sedang 3-5 kali dalam seminggu berpengaruh dalam penurunan massa lemak visceral pada pasien DM tipe 2. Sepuluh dari sebelas kepustakaan menggambarkan rerata massa lemak visceral pada pasien DM tipe 2. Mayoritas pengukuran massa lemak visceral dilakukan dengan menggunakan CT.
Kesimpulan: Aktivitas fisik intensitas sedang secara signifikan berperan dalam menurunkan massa lemak visceral, mengontrol kadar gula darah, dan memperbaiki sensitivitas insulin pada pasien DM tipe 2.
Kata Kunci: Aktivitas fisik, Diabetes Melitus tipe 2, Massa Lemak Visceral
PENYELESAIAN PERSELISIHAN HUBUNGAN INDUSTRIAL DILUAR PENGADILAN MELALUI ARBITRASE
Authors: Anwar Jumadi , Santoso Imam Budi 
Published: September 2023

Arbitration provides a procedure or process for resolving disputes peacefully and out of court. Arbitration opportunities for the sustainability of industrial relations in Indonesia are minimal things that will be implemented by all disputing parties because the community prioritizes settlement in terms of winning or losing through court settlements. It is very important that there are ways to support this arbitration as an option for resolving industrial disputes so that it is of interest to the public. The research method used in this study is a normative juridical research method with a descriptive approach, with the aim of providing direction and finding logical realistics by looking at library materials or other information using primary and secondary data. The results obtained from the conclusion of this discussion are the knowledge of the mechanism of arbitration in the settlement of disputes in the field of industrial relations and the advantages and disadvantages of arbitration in resolving problems in the field of industrial relations.
Keywords: Arbitration, Industry, Disputes.
A A REVIEW OF LEGAL CERTAINTY ON THE APPOINTMENT OF REGIONAL HEADS AND DEPUTY REGIONAL HEADS
Authors: Ananta Nur Averos Aulia 
Published: September 2023

Abstract
Regional governments are led by a head of the region who is assisted by a deputy head of the region. The head of the region has the authority as stipulated in the Regional Government Law. However, there are conditions where the head of the region cannot carry out their duties and authorities, namely when the head of the region resigns temporarily or permanently. This study will discuss the mechanism for filling vacant positions in the event of the absence of the head and deputy head of the region. The problem is that there are two positions responsible for filling the vacancy, but each of them does not have a complete regulation regarding the mechanism, requirements, and accountability. This condition creates legal uncertainty. Using normative juridical research methods, it is known that each of them does not have a complete regulation regarding the mechanism, requirements, and accountability. This condition creates legal uncertainty.
Keywords: head of region; delegation of authority; legal uncertainty.
Abstrak
Pemerintah daerah dipimpin oleh kepala daerah yang dibantu oleh seorang wakil kepala daerah. Kepala daerah memiliki wewenang sebagaimana yang tertulis dalam UU Pemerintahan Daerah. Namun, terdapat kondisi di mana kepala daerah tidak bisa menjalankan wewenang dan tugasnya yakni ketika kepala daerah berhenti sementara atau berhenti tetap. Penelitian ini akan membahas bagaimana mekanisme pengisian jabatan apabila terjadi kekosongan jabatan kepala daerah dan wakil kepala daerah. Permasalahannya adalah terdapat dua jabatan yang bertugas mengisi kekosongan jabatan tersebut. Dengan menggunakan metode penelitian yuridis normatif, diketahui bahwa masing-masing diantaranya belum memiliki peraturan yang lengkap terkait mekanisme, syarat, hingga pertanggungjawaban. Kondisi ini menimbulkan ketidakpastian hukum.
Kata kunci: kepala daerah; pendelegasian wewenang; ketidakpastian hukum.
PROBLEMATIKA HUKUM ATAS PERJANJIAN KERJA SAMA ANTARA BANK DENGAN NOTARIS DI INDONESIA: PERSPEKTIF TEORI KEADILAN BERMARTABAT
Authors: Amah Charles Njuka 
Published: September 2023

The legal problems of cooperation agreements between Banks and Notaries in Indonesia are actions or acts that injure human dignity. Notaries have a dominant position over their clients, so they have the potential to side with certain banks or developers. Even though notaries have a prohibition according to the Notary Code of Ethics Article 4 paragraph (4), the obligation to act impartially Article 16 paragraph (1) letter (a) UUJN. This research is a normative juridical research using statutory approach (Statute Approach) and Conceptual Approach. The results of the study found that the notary could potentially be negligent in respecting human dignity by having a cooperation agreement or becoming a bank partner or any other refined terminology, as if that could be justified, even though it is not in accordance with the values ​​or legal principles and values ​​of the Indonesian people. So that if there are actions that are inappropriate among notaries which are then not oriented towards fulfilling human dignity and have the potential for a dispute to occur which can harm other parties, then dignified justice can be a reference in making decisions, both by the Indonesian Notary Association Organization, the Honorary Council Notary and court.
Keywords: Notary Public servant; Dominant; and Dignified Justice.
Macaristan ve Polonya demokrasilerindeki gerilemenin siyasi kurumlar ve uluslararası aktörler çerçevesinde değerlendirilmesi
Authors: KÜÇÜKŞAHİN Muhammed Emre 
Published: September 2023

Günümüzde pek çok ülke insan hakları, hukukun üstünlüğü, serbest ve adil seçimler ve çoğulculuk gibi demokratik değerleri kısıtlayan yasal ve idari girişimlerde bulunmaktadır. Bu bağlamda demokrasi uzun yıllardır küresel anlamda gerileme içindedir. Bu durum demokratik gerilemenin ampirik olarak tespit edilmesini ve nedenlerinin araştırılmasını teşvik etmektedir.
Avrupa Birliği demokratik değerleri Birlik içinde yasal norm olarak kabul etmesine rağmen birden fazla üyesi hakkında demokratik gerileme içinde oldukları yönünde tartışmalar yürütülmektedir. Söz konusu üyelerden ikisi Macaristan ve Polonya olup iki ülkede hem Birlik içinde hem de uluslararası alanda anti demokratik uygulamaları nedeniyle eleştirilmektedir.
Bu çalışmada da Macaristan ve Polonya’nın demokratik gerileme içinde oldukları ampirik veriler ile ortaya konulmakta ve bunun nedenleri siyasal kurumlar ve uluslararası faktörler çerçevesinde açıklanmaktadır.
Cigarette smoke restricts the ability of mesenchymal cells to support lung epithelial organoid formation
Authors: Khedoe P. P. S. J. , van Schadewijk W. A. A. M. , Schwiening M. , Ng-Blichfeldt J. P. , Marciniak S. J. , Stolk J. , Gosens R. , Hiemstra P. S. 
Published: September 2023

Adequate lung epithelial repair relies on supportive interactions within the epithelial niche, including interactions with WNT-responsive fibroblasts. In fibroblasts from patients with chronic obstructive pulmonary disease (COPD) or upon in vitro cigarette smoke exposure, Wnt/β-catenin signalling is distorted, which may affect interactions between epithelial cells and fibroblasts resulting in inadequate lung repair. We hypothesized that cigarette smoke (CS), the main risk factor for COPD, interferes with Wnt/β-catenin signalling in fibroblasts through induction of cellular stress responses, including oxidative- and endoplasmic reticulum (ER) stress, and thereby alters epithelial repair support potential. Therefore, we assessed the effect of CS-exposure and the ER stress inducer Thapsigargin (Tg) on Wnt/β-catenin signalling activation in MRC-5 fibroblasts, and on their ability to support lung epithelial organoid formation. Exposure of MRC-5 cells for 15 min with 5 AU/mL CS extract (CSE), and subsequent 6 h incubation induced oxidative stress (HMOX1). Whereas stimulation with 100 nM Tg increased markers of both the integrated stress response (ISR - GADD34/PPP1R15A, CHOP) and the unfolded protein response (UPR - XBP1spl, GADD34/PPP1R15A, CHOP and HSPA5/BIP), CSE only induced GADD34/PPP1R15A expression. Strikingly, although treatment of MRC-5 cells with the Wnt activator CHIR99021 upregulated the Wnt/β-catenin target gene AXIN2, this response was diminished upon CSE or Tg pre-exposure, which was confirmed using a Wnt-reporter. Furthermore, pre-exposure of MRC-5 cells to CSE or Tg, restricted their ability to support organoid formation upon co-culture with murine pulmonary EpCam+ cells in Matrigel at day 14. This restriction was alleviated by pre-treatment with CHIR99021. We conclude that exposure of MRC-5 cells to CSE increases oxidative stress, GADD34/PPP1R15A expression and impairs their ability to support organoid formation. This inhibitory effect may be restored by activating the Wnt/β-catenin signalling pathway.
Diagnostic yield of genetic testing in a multinational heterogeneous cohort of 2088 DCM patients
Authors: Heliö Krista , Cicerchia Marcos , Hathaway Julie , Tommiska Johanna , Huusko Johanna , Saarinen Inka , Koskinen Lotta , Muona Mikko , Kytölä Ville , Djupsjöbacka Janica , Gentile Massimiliano , Salmenperä Pertteli , Alastalo Tero-Pekka , Steinberg Christian , Heliö Tiina , Paananen Jussi , Myllykangas Samuel , Koskenvuo Juha 
Published: September 2023

BackgroundFamilial dilated cardiomyopathy (DCM) causes heart failure and may lead to heart transplantation. DCM is typically a monogenic disorder with autosomal dominant inheritance. Currently disease-causing variants have been reported in over 60 genes that encode proteins in sarcomeres, nuclear lamina, desmosomes, cytoskeleton, and mitochondria. Over half of the patients undergoing comprehensive genetic testing are left without a molecular diagnosis even when patient selection follows strict DCM criteria.Methods and resultsThis study was a retrospective review of patients referred for genetic testing at Blueprint Genetics due to suspected inherited DCM. Next generation sequencing panels included 23–316 genes associated with cardiomyopathies and other monogenic cardiac diseases. Variants were considered diagnostic if classified as pathogenic (P) or likely pathogenic (LP). Of the 2,088 patients 514 (24.6%) obtained a molecular diagnosis; 534 LP/P variants were observed across 45 genes, 2.7% (14/514) had two diagnostic variants in dominant genes. Nine copy number variants were identified: two multigene and seven intragenic. Diagnostic variants were observed most often in TTN (45.3%), DSP (6.7%), LMNA (6.7%), and MYH7 (5.2%). Clinical characteristics independently associated with molecular diagnosis were: a lower age at diagnosis, family history of DCM, paroxysmal atrial fibrillation, absence of left bundle branch block, and the presence of an implantable cardioverter-defibrillator.ConclusionsPanel testing provides good diagnostic yield in patients with clinically suspected DCM. Causative variants were identified in 45 genes. In minority, two diagnostic variants were observed in dominant genes. Our results support the use of genetic panels in clinical settings in DCM patients with suspected genetic etiology.
Obesity accelerates endothelial-to-mesenchymal transition in adipose tissues of mice and humans
Authors: Chavkin Nicholas W. , Vippa Tanvi , Jung Changhee , McDonnell Stephanie , Hirschi Karen K. , Gokce Noyan , Walsh Kenneth 
Published: September 2023

IntroductionVascular dysfunction and chronic inflammation are characteristics of obesity-induced adipose tissue dysfunction. Proinflammatory cytokines can drive an endothelial-to-mesenchymal transition (EndoMT), where endothelial cells undergo a phenotypic switch to mesenchymal-like cells that are pro-inflammatory and pro-fibrotic. In this study, we sought to determine whether obesity can promote EndoMT in adipose tissue.MethodsMice in which endothelial cells are lineage-traced with eYFP were fed a high-fat/high-sucrose (HF/HS) or Control diet for 13, 26, and 52 weeks, and EndoMT was assessed in adipose tissue depots as percentage of CD45−CD31−Acta2+ mesenchymal-like cells that were eYFP +. EndoMT was also assessed in human adipose endothelial cells through cell culture assays and by the analysis of single cell RNA sequencing datasets obtained from the visceral adipose tissues of obese individuals.ResultsQuantification by flow cytometry showed that mice fed a HF/HS diet display a time-dependent increase in EndoMT over Control diet in subcutaneous adipose tissue (+3.0%, +2.6-fold at 13 weeks; +10.6%, +3.2-fold at 26 weeks; +11.8%, +2.9-fold at 52 weeks) and visceral adipose tissue (+5.5%, +2.3-fold at 13 weeks; +20.7%, +4.3-fold at 26 weeks; +25.7%, +4.8-fold at 52 weeks). Transcriptomic analysis revealed that EndoMT cells in visceral adipose tissue have enriched expression of genes associated with inflammatory and TGFβ signaling pathways. Human adipose-derived microvascular endothelial cells cultured with TGF-β1, IFN-γ, and TNF-α exhibited a similar upregulation of EndoMT markers and induction of inflammatory response pathways. Analysis of single cell RNA sequencing datasets from visceral adipose tissue of obese patients revealed a nascent EndoMT sub-cluster of endothelial cells with reduced PECAM1 and increased ACTA2 expression, which was also enriched for inflammatory signaling genes and other genes associated with EndoMT.DiscussionThese experimental and clinical findings show that chronic obesity can accelerate EndoMT in adipose tissue. We speculate that EndoMT is a feature of adipose tissue dysfunction that contributes to local inflammation and the systemic metabolic effects of obesity..