bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of Stock Investment Decisions through Price Earnings Ratio (A Case Study on Construction Service Companies)
Authors: Alfarago Dio , Bakhtiyar Luthfi Aziz 
Published: May 2023

The objective of this study is to analyze investment decisions using the Price Earnings Ratio (P/E Ratio) approach. The sample companies for this study are construction service companies that are listed on the Indonesia Stock Exchange in 2021. This study combines descriptive and quantitative methods. The results indicated that PT. Waskita Karya Tbk., PT. Wijaya Karya Tbk., PT. Adhi Karya Tbk., and PT. Pembangunan Perumahan Tbk. are sequentially the company with the highest investment priority. This priority scale can be taken into account by investors when making investments.
Optimization of Government Communication Department of Tourism, Youth And Sports of Maros Regency in Rammang – Rammang Tourism Village Development in Bontoa District
Authors: Rezki Pratama Putra Andi , Zelfia Zelfia , Muliadi Muliadi 
Published: May 2023

The purpose of this study was to examine the optimization of Communication Department of Tourism, Youth and sports as well as inhibiting and supporting factors in the development of Tourism Village. This study uses the method of quality description, with information in this study as many as eight (8) people, data collection techniques through observation, interviews and documentation.
The development of Rammang – Rammang Tourism Village is to build image and cooperation by doing development to the tourism management community through training on improving human resources capacity to improve the welfare and prosperity of the community in managing a directed Tourism Village. The supporting and inhibiting factors are in the management of Rammang-Rammang tourism development as a geological park or geo park Maros-Pangkep, because Rammang-Rammang is the 2nd largest karst mountain area in the world.
Single Parent Family Communication Patterns in Girls' Self-Concepts in Wajo District, Makassar City
Authors: Nurul Aulia Ihsanie , Muttaqin Mustari Andi , Idris Muhammad 
Published: May 2023

The purpose of this study was to determine the pattern of family communication in the development of the self-concept of girls (single parent) in Wajo District, Makassar City and to determine the pattern of development (Single Parent) in developing the self-concept of girls with their families in order to establish good communication. This research uses descriptive analysis qualitative research method. This study intends to describe the description of single parents in developing their daughter's self-concept through family communication patterns to guide and provide support to daughters. The selected informants include people who are selected on the basis of certain criteria. This research was conducted by collecting data through observation, interviews, and documentation. This research was conducted for one month and located in Wajo District, Makassar City.
The results of this study indicate that the pattern of family communication in developing the self- concept of single mother girls by using communication patterns is given through interpersonal communication where parents are communicators and the efforts given by single parents to girls are generated from experiences that have been passed and communication with parents make the nature, behavior, emotional, and social can be positive or negative. The form of communication used by single mothers in developing their daughter's self- concept uses interpersonal communication in the form of direction, teachings, guidance, experience and word of mouth motivation. The guidance provided is maximal enough to develop the child's self-concept as a guide in the future.
Is Allergic Rhinitis Associated With Enuresis Nocturna In Childhood ?
Authors: YASAR Adem , YILMAZ Özge , YUKSEL H 
Published: May 2023

Introduction
Allergic rhinitis is the most common form of non-infectious rhinitis and is manifested with the symptoms of nasal congestion, sneezing, nasal discharge, and itching. Primary enuresis nocturna is involuntary urination while asleep after five years, at which bladder control usually begins. Our objective was to evaluate the relationship between allergic rhinitis and primary enuresis nocturna in childhood in this research.
Methods:
We included 300 children with allergic rhinitis and 300 control cases between the age of 5 and 17 years. With allergic rhinitis cases, age, gender, body mass index percentile, other allergic disorders, allergic rhinitis diagnosis age, allergic rhinitis severity and distribution, presence of primary enuresis nocturna, and presence of primary enuresis nocturna in the family were recorded. Subjects with disorders causing enuresis were excluded from the study.
Results:
The mean age in the allergic rhinitis and control groups was 9,6±3,4 vs. 10,0±3,1 years, respectively (p=0,15). There was no statistical difference between the two groups in terms of gender, age, body mass index percentile, and primary enuresis nocturna presence in the family (p=0.29, p=0.15, p=0.46, p=0.17; respectively). Primary enuresis nocturna was significantly higher in allergic rhinitis cases (p=0.02). Primary enuresis nocturna was significantly higher in boys than in girls (p=0.007). There is a significant difference in age and gender between those with and without primary enuresis nocturna in allergic rhinitis groups (p=0,001, p=0.01, respectively).
Conclusion:
We conclude that as allergic rhinitis increases the incidence of primary enuresis nocturna and worsens the quality of life, its treatment should not be neglected.
Turkish Adaptation of Nursing Students Competence Instrument
Authors: ÇAKAR Merve , AÇIL Ayşegül , İLASLAN Nagihan , YILDIRIM ŞİŞMAN Nuriye 
Published: May 2023

Objective: The study was conducted to examine the validity and reliability of the Nursing Students Competence Instrument, which was developed in order to evaluate the competences of nursing students, for the Turkish society.
Methods: This methodological study was conducted with the participation of 224 third and fourth-year nursing students studying at a state university in Turkey. Identifying Information Form and Nursing Students Competence Instrument were used for data collection. In order to determine the validity of the scale, linguistic content validity analysis and confirmatory factor analysis were performed. In order to identify the reliability of the scale, test-retest and Cronbach’s alpha analysis were used.
Results: In line with the validity and reliability analyses of the scale, it was determined that the model was compatible according to fit indices of confirmatory factor analysis (X2/sd= 2.42, RMSEA= 0.08, SRMR= 0.07). The Cronbach’s alpha coefficient of the scale was determined to be 0.96, and the Cronbach’s alpha coefficients of the subscales varied between 0.92 and 0.94.
Conclusion: It was determined that the Turkish adaptation of the “Nursing Students Competence Instrument” was a valid and reliable scale for measuring the competence levels of nursing students. It is recommended to administer the scale to larger samples and to plan interorganizational comparative studies in order to identify nursing students’ competences.
Turkish Adaptation of Patient Nurse Trust Scale: A Validity and Reliability Study
Authors: OKUROĞLU Gülten , COŞKUNER POTUR Dilek , AFŞAR Füsun 
Published: May 2023

Objective: This study aims to adapt the Patient-Nurse Trust Scale to Turkish and perform validity and reliability analyses.
Methods: This study has been conducted as methodological. It was conducted between February 2021 and June 2021 in a training and research hospital in Istanbul, Turkey. The study was completed with 311 participants. Introductory Information Form, Patient-Nurse Trust Scale, and Trust in Nurses Scale were used for data collection. In addition to descriptive statistics, language validity, content validity, construct validity, criterionrelated validity, discrimination, internal consistency reliability, two-half test reliability, and item analysis methods were used to determine the scale’s psychometric properties.
Results: As a result of factor analysis, it was determined that the scale showed a single factor structure, and explained 66.63% of the total variance. Item factor load values were found to vary between .74 and .88. The ratio of the chi-square value to the degrees of freedom (397.496/112) was found to be 3.549. It was found that RMSEA= .09, GFI= .86, IFI= .93, NFI= .91, CFI= .93, and RFI= .87. It was found that the correlations of all items varied between .71 and .87. The Chronbach’s alpha value for the whole scale was calculated as .97. As a result of parallel test analysis, it was determined that there was a significant positive correlation between both scales (r= .301; p= .000).
Conclusion: The exploratory factor analysis and confirmatory factor analysis results of the Turkish version of the scale are acceptable, and their reliability indexes are high.
Accuracy of Dental and Chronological Age Estimation in A Sample Turkish Caucasion Children:Comparison of Demirjian’s and Willems Methods
Authors: İZGİ Elif , NAMDAR PEKİNER Filiz Mediha 
Published: May 2023

Objective: The purpose of this study is to apply Demirjian’s and Willems’ methodologies and to define whether there are any discrepancies in
predicting dental age versus chronological age in a sample Turkish Caucasian children.
Methods: A total of 150 Turkish Caucasian children with known chronological age and gender were chosen. The chronological age was determined by subtracting the date of birth from the date of the radiograph, and it was expressed as a number with two decimal places. Each age group was determined to have a minimum sample size of 12 and a maximum sample size of 27. All panoramic radiographs were scored according to the criteria of Demirjian’s and Willems methodologies with Onyx Ceph 3.1.54 software.
Results: The dental ages of the cases ranged from 4.82 to 15.66 years calculated by the Demirjian’s method, with an average of 9.47±2.27 years, while the Willems method of the cases ranged from 4.13 to 14.34 years calculated by the Demirjian’s method, with an average of 8.87±2.24 years. According to Demirjian’s method, in the developmental evaluation of dental age, 45.3% of boys were found to have a statistically higher chronological age than girls (p.05).
Conclusion: The Willems method was shown to be more accurate in determining dental age in Turkish children. Further studies on large population groups and diverse ethnicities are required to increase the reliability and repeatability of the results.
Postgraduate Dental Students’ Knowledge Levels Toward Medication-Related Osteonecrosis of the Jaws
Authors: ASLAN Elif , ŞENER Elif , ÖNEM Erinc , MERT Ali , ÇANKAYA Hülya 
Published: May 2023

Objective: Objective: Medication-related osteonecrosis of the jaws (MRONJ), is often described as a side-effect of bisphosphonates within the dental school curriculum. However, as highlighted in the current literature, some antiresorptive and antiangiogenic drugs may also cause MRONJ. This study aimed to investigate the awareness and knowledge of post-graduate dental students (PDSs) from different specialty/doctoral programs towards MRONJ.
Methods: An electronic questionnaire containing 28 questions in 3 different sections focusing on demographic characteristics, general information, and clinical attitude, was prepared. Two-thousand PDSs from 27 universities were invited to participate in the survey in December 2021. The obtained data were evaluated statistically using descriptive statistics and the Chi-Square test (p=.05).
Results: The response rate of the survey was 10%. The number of PDSs showed a homogeneous distribution for each specialty, whereas the number of women participants was higher than that of men (p.05). PDSs had higher rates of correct answers to general information questions about antiresorptive drugs than for antiangiogenic drugs. 92% of participants stated that they obtained their knowledge about MRONJ from their undergraduate education.
Conclusion: The findings of this study reveal the necessity of updating the dental school curriculum in line with the current literature on MRONJ, as well as including more postgraduate courses on MRONJ during the specialty/doctoral education period.
Gut microbiota and type 1 diabetes: a two-sample bidirectional Mendelian randomization study
Authors: Luo Manjun , Sun Mengting , Wang Tingting , Zhang Senmao , Song Xinli , Liu Xiaoying , Wei Jianhui , Chen Qian , Zhong Taowei , Qin Jiabi 
Published: May 2023

ObjectiveThe real causal relationship between human gut microbiota and T1D remains unclear and difficult to establish. Herein, we adopted a two-sample bidirectional mendelian randomization (MR) study to evaluate the causality between gut microbiota and T1D.MethodsWe leveraged publicly available genome-wide association study (GWAS) summary data to perform MR analysis. The gut microbiota-related GWAS data from 18,340 individuals from the international consortium MiBioGen were used. The summary statistic data for T1D (n = 264,137) were obtained from the latest release from the FinnGen consortium as the outcome of interest. The selection of instrumental variables conformed strictly to a series of preset inclusion and exclusion criteria. MR-Egger, weighted median, inverse variance weighted (IVW), and weighted mode methods were used to assess the causal association. The Cochran’s Q test, MR-Egger intercept test, and leave-one-out analysis were conducted to identify heterogeneity and pleiotropy.ResultsAt the phylum level, only Bacteroidetes was indicated to have causality on T1D (OR = 1.24, 95% CI = 1.01-1.53, P = 0.044) in the IVW analysis. When it comes to their subcategories, Bacteroidia class (OR = 1.28, 95% CI = 1.06-1.53, P = 0.009, PFDR = 0.085), Bacteroidales order (OR = 1.28, 95% CI = 1.06-1.53, P = 0.009, PFDR = 0.085), and Eubacterium eligens group genus (OR = 0.64, 95% CI = 0.50-0.81, P = 2.84×10-4, PFDR = 0.031) were observed to have a causal relationship with T1D in the IVW analysis. No heterogeneity and pleiotropy were detected.ConclusionsThe present study reports that Bacteroidetes phylum, Bacteroidia class, and Bacteroidales order causally increase T1D risk, whereas Eubacterium eligens group genus, which belongs to the Firmicutes phylum, causally decreases T1D risk. Nevertheless, future studies are warranted to dissect the underlying mechanisms of specific bacterial taxa’s role in the pathophysiology of T1D.
Zero echo time MRI improved detection of erosions and sclerosis in the sacroiliac joint in comparison with LAVA-flex
Authors: Lin Churong , Liu Dong , Wen Huiquan , Liu Budian , Tu Liudan , Gu Jieruo 
Published: May 2023

BackgroundT1-weighted spoiled 3D Gradient Recalled Echo pulse sequences, exemplified by Liver Acquisition with Volume Acceleration-flexible MRI (LAVA-Flex), are currently the preferred MR sequence for detecting erosions of the sacroiliac joint (SIJ). However, zero echo time MRI (ZTE) is recently reported to provide excellent visualization of the cortical bone.PurposeTo directly compare the diagnostic accuracy of ZTE and LAVA-Flex in the detection of structural lesions of the SIJ, including erosions, sclerosis and joint space changes.Materials and methodsTwo readers independently reviewed the ldCT, ZTE and LAVA-Flex images of 53 patients diagnosed as axSpA and scored the erosions, sclerosis and joint space changes. Sensitivity, specificity and Cohen’s kappa (κ) of ZTE and LAVA-Flex were calculated, while McNemar’s test was employed to compare the two sequences for the positivity of detecting the structural lesions.ResultsAnalysis of diagnostic accuracy showed a higher sensitivity of ZTE in comparison with LAVA-Flex in the depiction of erosions (92.5% vs 81.5%, p&lt;0.001), especially first-degree erosions (p&lt;0.001) and second-degree erosions (p&lt;0.001), as well as sclerosis (90.6% vs 71.2%, p&lt;0.001), but not joint space changes (95.2% vs 93.8%, p=0.332). Agreement with ldCT was also higher in ZTE in the detection of erosions than LAVA-Flex as indicated by the κ values (0.73 vs 0.47), as well as in the detection of sclerosis (0.92 vs 0.22).ConclusionWith ldCT as the reference standard, ZTE could improve diagnostic accuracy of erosions and sclerosis of the SIJ in patients suspected of axSpA, in comparison with LAVA-Flex.
Neuro-PASC is characterized by enhanced CD4+ and diminished CD8+ T cell responses to SARS-CoV-2 Nucleocapsid protein
Authors: Visvabharathy Lavanya , Hanson Barbara A. , Orban Zachary S. , Lim Patrick H. , Palacio Nicole M. , Jimenez Millenia , Clark Jeffrey R. , Graham Edith L. , Liotta Eric M. , Tachas George , Penaloza-MacMaster Pablo , Koralnik Igor J. 
Published: May 2023

IntroductionMany people with long COVID symptoms suffer from debilitating neurologic post-acute sequelae of SARS-CoV-2 infection (Neuro-PASC). Although symptoms of Neuro-PASC are widely documented, it is still unclear whether PASC symptoms impact virus-specific immune responses. Therefore, we examined T cell and antibody responses to SARS-CoV-2 Nucleocapsid protein to identify activation signatures distinguishing Neuro-PASC patients from healthy COVID convalescents.ResultsWe report that Neuro-PASC patients exhibit distinct immunological signatures composed of elevated CD4+ T cell responses and diminished CD8+ memory T cell activation toward the C-terminal region of SARS-CoV-2 Nucleocapsid protein when examined both functionally and using TCR sequencing. CD8+ T cell production of IL-6 correlated with increased plasma IL-6 levels as well as heightened severity of neurologic symptoms, including pain. Elevated plasma immunoregulatory and reduced pro-inflammatory and antiviral response signatures were evident in Neuro-PASC patients compared with COVID convalescent controls without lasting symptoms, correlating with worse neurocognitive dysfunction.DiscussionWe conclude that these data provide new insight into the impact of virus-specific cellular immunity on the pathogenesis of long COVID and pave the way for the rational design of predictive biomarkers and therapeutic interventions.
T cell receptor and B cell receptor exhibit unique signatures in tumor and adjacent non-tumor tissues of hepatocellular carcinoma
Authors: Xie Shi , Yan Rong , Zheng Anqi , Shi Mengfen , Tang Longqing , Li Xueying , Liu Jiabang , Gan Yifan , Wang Yu , Jiang Deke , Liu Li , Wu Hongkai , Wang Zhanhui 
Published: May 2023

BackgroundThe tumor microenvironment in hepatocellular carcinoma (HCC) is complicated. Tumor-infiltrating T and B cells play a pivotal role in anti-tumor immunity. T cell receptor (TCR) and B cell receptor (BCR) features may reflect the disease-associated antigen response.MethodsBy combining bulk TCR/BCR-sequencing, RNA-sequencing, whole exome-sequencing, and human leukocyte antigen-sequencing, we examined the immune repertoire (IR) features of tumor and adjacent non-tumor tissues obtained from 64 HCC patients.ResultsHigh IR heterogeneity with weak similarity was discovered between tumor and non-tumor tissues. Higher BCR diversity, richness, and somatic hypermutation (SHM) were found in non-tumor tissues, while TCRα and TCRβ diversity and richness were comparable or higher in tumor. Additionally, lower immune infiltration was found in tumor than non-tumor tissues; the microenvironment in tumor appeared to keep stably inhibited and changed slightly with tumor progression. Moreover, BCR SHM was stronger, whereas TCR/BCR diversity declined with HCC progression. Importantly, we found that higher IR evenness in tumor and lower TCR richness in non-tumor tissues indicated better survival in HCC patients. Collectively, the results revealed that TCR and BCR exhibited distinct features in tumor and non-tumor tissues.ConclusionsWe demonstrated that IR features vary between different tissues of HCC. IR features may represent a biomarker for the diagnosis and treatment of HCC patients, providing references for subsequent immunotherapy research and strategy selection.
Cost-effectiveness analysis of toripalimab plus chemotherapy versus chemotherapy alone for advanced non-small cell lung cancer in China
Authors: Zhang Mengdie , Xu Kai , Lin Yingtao , Zhou Chongchong , Bao Yuwen , Zhang Lingli , Li Xin 
Published: May 2023

BackgroundToripalimab is the first domestic anti-tumor programmed death 1 antibody marketed in China. The CHOICE-01 trial (identifier: NCT 03856411) demonstrated that toripalimab plus chemotherapy can significantly improve the clinical outcomes of advanced non-small cell lung cancer (NSCLC) patients. However, whether it is cost-effective remains unknown. Given the high cost of combination therapy, a cost-effectiveness analysis of toripalimab plus chemotherapy (TC) versus chemotherapy alone (PC) for the first-line treatment of patients with advanced NSCLC is required.MethodsA partitioned survival model was adopted to predict the course of disease in advanced NSCLC patients on TC or PC from the perspective of the Chinese healthcare system over a 10-year horizon. The survival data were obtained from the CHOICE-01 clinical trial. Cost and utility values were obtained from local hospitals and kinds of literature. Based on these parameters, the incremental cost-effectiveness ratio (ICER) of TC vs. PC was measured, and one-way sensitivity analyses, probabilistic sensitivity analyses (PSA), and scenario analyses were performed to assess the robustness of the model.ResultsIn the base case, TC was associated with an incremental cost of $18510 and an incremental quality-adjusted life year (QALY) of 0.57 compared with PC, resulting in an ICER of $32237/QALY which was lower than the willingness to pay (WTP) threshold ($37654/QALY), TC was cost-effective. The health utility value of progression-free survival, the price of toripalimab, and the cost of best supportive care were factors that significantly influenced the ICER, but no change in any of them could change the model result. TC showed a 90% probability of being a cost-effective option at a WTP threshold of $37,654/QALY. In the 20 and 30-year time horizons, the results remained unchanged and TC remained cost-effective when the second-line treatment was switched to docetaxel.ConclusionAt a WTP threshold of $37,654 per QALY, TC was cost-effective compared to PC for patients with advanced NSCLC in China.