bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of the risk of burnout and its associated factors in healthcare professionals during the COVID-19 pandemic: A prospective cohort study
Authors: Silva Rebeca R. C. , Menezes Rodrigo C. , Garcia Stefania L. , Pustilnik Hugo N. , Ferreira Isabella B. B. , Aguiar Kaique V. C. S. , Filgueiras Filho Nivaldo M. , Araújo-Pereira Mariana , Andrade Bruno B. 
Published: January 2023

IntroductionThe COVID-19 pandemic resulted in tremendous physical and psychological pressure on healthcare professionals, especially on those working in intensive care units (ICUs) and Emergency Departments (EDs). The present study intended to characterize the profile of these professionals which is associated with burnout and determine the potential predictors of such condition.MethodsA Prospective cohort study was carried out in a tertiary hospital between March 2020 and March 2021, in Salvador, Brazil. A standardized and validated version of the Oldenburg Burnout inventory (OLBI) was applied to assess risk of burnout together with data forms designed to collect information on sociodemographic characteristics and religious beliefs. ICU and ED healthcare professionals were evaluated during off-hours at two distinct periods of the COVID-19 pandemic, in 2020 and in 2021. Differences in the results obtained from each study participant between the timepoints were compared. A binary logistic regression analysis was performed to identify the predictors of burnout development independent of other confounding factors.ResultsSeventy-seven healthcare professionals with a median age of 33 (interquartile range [IQR]: 31–37.5) years and predominantly female (72.7%; n = 56) were enrolled. There were 62 professionals at risk of developing burnout through the OLBI. Those had a median age of 33 (IQR: 31–37) and female predominance (71%, n = 44). Disengagement and burnout were the only features which frequencies significantly changed over time, with increasing detection at the latest timepoint. Alcohol consumption was found to be an important risk factor for burnout development [adjusted odds ratio (aOR): 10.8 (95% CI: 1.8–64.2)]. Importantly, working in the ICU [aOR: 0.04 (95%CI: 0.01–0.32)] and the habit of praying daily [aOR: 0.07 (95%CI: 0.01–0.41)] were characteristics linked to reduced odds of burnout.DiscussionDisengagement substantially increased during the COVID-19 pandemic in healthcare professionals. Alcohol consumption favors the onset of burnout whereas habit of praying daily and working in the ICU are protective against such outcome. Institutional policies aimed at minimizing etilism may positively impact mental health of these professionals.
The risk assessment of relapse among newly enrolled participants in methadone maintenance treatment: A group-LASSO based Bayesian network study
Authors: Tang Xijia , Fan Chaonan , Wang Chijie , Wang Wenjuan , Chen Zouxiang , Xu Chaofan , Ling Li 
Published: January 2023

BackgroundRelapse is a great barrier to improving the effectiveness of methadone maintenance treatment (MMT). Participants with different treatment durations could vary in their compliance with MMT, which may lead to different levels of relapse risk. This study aims to identify the risk factors for relapse and assess the relapse risk of MMT participants of different treatment durations.MethodThis retrospective study used data collected from seven MMT clinics in Guangdong Province, China, from January 2010 to April 2017. Newly enrolled participants who received 6 (n = 903) and 12 (n = 710) months of consecutive treatment with complete data were included. We selected significant risk factors for relapse through the group lasso regression and then incorporated them into Bayesian networks to reveal relationships between factors and predict the relapse risk.ResultsThe results showed that participants who received 6-month treatment had a lower relapse rate (32.0%) than those of 12-month treatment (39.0%, P &lt; 0.05). Factors including personal living status and daily methadone dose were only influential to those who received the 6-month treatment. However, age, age at the initial drug use, HIV infection status, sexual behaviors, and continuous treatment days were common factors of both durations. The highest relapse risk for those after the 6-month treatment was inferred as 66.7% while that of the 12-month treatment was 83.3%. Farmers and those who have high accessibility to MMT services may require additional attention.ConclusionIt is necessary to implement targeted interventions and education based on the treatment durations of participants to decrease the relapse rate. Meanwhile, those about HIV/sexually transmitted infection prevention and anti-narcotics should be held in the whole process.
Repair of rotator cuff tears in patients aged 75 years and older: Does it make sense? A systematic review
Authors: Meng Chenyang , Jiang Boyong , Liu Ming , Kang Fujia , Kong Lingyue , Zhang Ting , Wang Caixia , Wang Jingjuan , Han Changxu , Ren Yizhong 
Published: January 2023

BackgroundRotator cuff injuries are common, and morbidity increases with age. The asymptomatic full-thickness tear rate is 40% in the over 75-year-old population.PurposeThis study aimed to systematically review the literature on the outcomes of rotator cuff repair among &gt;75 years old patients.Study designSystematic review.MethodsA systematic review of the literature was performed following the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. A literature search was performed in the electronic databases of PubMed, Medline, Embase, and The Cochrane Library. Studies in English evaluating repair of full-thickness rotator cuff tears in patients aged &gt;75 years were included.ResultsSix studies were reviewed, including 311 patients (313 shoulders) treated with arthroscopic and/or open rotator cuff repair. Sixty-one patients were lost to follow-up, leaving 252 shoulders with outcome data. Patients in this age group demonstrated a significant improvement in the clinical and functional scores after rotator cuff repair, with a high satisfaction rate. The mean American Shoulder and Elbow Surgeons scores improved from 43.8 (range, 42.0–45.5) preoperatively to 85.3 (range, 84.0 to 86.5) postoperatively, and the mean Constant scores improved from 45.4 (range, 34.7–55.5) to 78.6 (range, 67.0–91.6). Pain, evaluated in all studies by the visual analog scale for pain, showed a significant improvement at the last follow-up compared with the mean preoperative score. Furthermore, range of motion and return to daily activities and sports gained marked improvements.ConclusionRotator cuff repair in patients aged &gt;75 years could achieve high clinical success rates with good outcomes and pain relief. Although patients in this age group are at a high risk of retear, rotator cuff repair may offer a good option with significant functional and clinical improvement.
Public-private partnership to rapidly strengthen and scale COVID-19 response in Western Kenya
Authors: van Duijn Shannen , Barsosio Hellen C. , Omollo Mevis , Milimo Emmanuel , Akoth Isdorah , Aroka Robert , de Sanctis Teresa , K'Oloo Alloys , June Micah J. , Houben Nathalie , Wilming Charlotte , Otieno Kephas , Kariuki Simon , Onsongo Simon , Odhiambo Albert , Ganda Gregory , Rinke de Wit Tobias F. 
Published: January 2023

IntroductionIn Africa almost half of healthcare services are delivered through private sector providers. These are often underused in national public health responses. To support and accelerate the public sector's COVID-19 response, we facilitated recruitment of additional private sector capacity by initiating a public-private partnership (PPP) in Kisumu County, Kenya. In this manuscript we demonstrate this PPP's performance.MethodsCOVID-19 diagnostic testing formed the basis for a PPP between Kenyan Medical Research Institute (KEMRI), Department of Health Kisumu County, PharmAccess Foundation, and local faith-based and private healthcare facilities: COVID-Dx. First phase COVID-Dx was implemented from June 01, 2020, to March 31, 2021 in Kisumu County, Kenya. Trained laboratory technologists in participating healthcare facilities collected nasopharyngeal and oropharyngeal samples from patients meeting the Kenyan MoH COVID-19 case definition. Healthcare workers in participating facilities collected patient clinical data using a digitized MoH COVID-19 Case Identification Form. We shared aggregated results from these data via (semi-) live dashboards with all relevant stakeholders through their mobile phones and tablets. Statistical analyses were performed using Stata 16 to inform project processes.ResultsNine private facilities participated in the project. A patient trajectory was developed from case identification to result reporting, all steps supported by a semi-real time digital dashboard. A total of 4,324 PCR tests for SARS-CoV-2 were added to the public response, identifying 425 positives, accounting for 16% of all COVID-19 tests performed in the County over the given time-period. Geo-mapped and time-tagged information on incident cases was depicted on Google maps through PowerBI-dashboards and fed back to policymakers for informed rapid decision making. Preferential COVID-19 testing was performed on health workers at risk, with 1,009 tests performed (up to 43% of all County health workforce).ConclusionWe demonstrate feasibility of rapidly increasing the public health sector COVID-19 response through coordinated private sector efforts in an African setting. Our PPP intervention in Kisumu, Kenya was based on a joint testing strategy and demonstrated that semi-real time digitalization of patient trajectories can gain significant efficiencies, linking public and private healthcare efforts, increasing transparency, support better quality health services and informing policy makers to target interventions.
Escaping negative moods and concentration problems play bridge roles in the symptom network of problematic smartphone use and depression
Authors: Wei Xinyi , An Fei , Liu Chang , Li Kuiliang , Wu Lin , Ren Lei , Liu Xufeng 
Published: January 2023

BackgroundProblematic smartphone use (PSU) has become an issue of great concern in the age of smartphones. PSU is associated with emotional problems, one of which is depression, as shown by empirical studies. However, previous studies have been limited in that they have focused solely on the total score for symptoms of PSU and depression while ignoring the symptomatic heterogeneity of these two concepts.MethodThis study filled this gap by exploring links between symptoms of PSU and depression among 1,849 university students (59.17% female participants, 17–23 years old). Network analysis was utilized to reveal symptom connections, central symptoms, and bridge symptoms between PSU and depression.Results(1) A total of 17 of 81 symptom connections (about 21%) between PSU and depression existed in the symptom network. For example, “self-control failure” for PSU was positively correlated with “concentration problems” for depression; (2) “recklessly continuing” for PSU and “fatigue” for depression were central symptoms within the PSU symptom network and depression symptom network, respectively; (3) “escaping negative moods” for PSU and “concentration problems” for depression were bridge symptoms. The former was maximumly connected with the depression symptoms and the latter was maximumly connected with the PSU symptoms; and (4) gender had very minimal influence on the network characteristics.ConclusionThe results are in keeping with the central idea of the compensatory internet use theory that excessive smartphone use may be a coping strategy for depressed emotions derived from escaping motivation. Moreover, concentration problems may be a mediator explaining how negative emotions (e.g., depression) cause PSU, which is undefined in current internet use theories. Finally, symptom connections, central symptoms, and bridge symptoms could be potential targets for the prevention and intervention of PSU and depression in young adults.
Quantitative analysis of local microcirculation changes in early osteonecrosis of femoral head: DCE-MRI findings
Authors: Li Pinxue , Xie Congqin , Liu Yubo , Wen Zhentao , Nan Shaokui , Yu Fangyuan 
Published: January 2023

AimThis study aims to quantitatively analyze the changes in local microcirculation in early osteonecrosis of the femoral head (ONFH) by dynamic contrast-enhanced (DCE) MRI and to explore the pathophysiological mechanisms of early ONFH.Patients and MethodsWe selected 49 patients (98 hips) aged 21–59 years who were clinically diagnosed with early ONFH. A total of 77 femoral heads were diagnosed with different degrees of necrosis according to the Association Research Circulation Osseous (ARCO) staging system, and 21 femoral heads were judged to be completely healthy. All patients underwent DCE-MRI scanning. Pseudocolor images and time-signal intensity curves were generated by Tissue 4D processing software. The volume transfer constant (Ktrans), extracellular extravascular space, also known as vascular leakage (Ve), and transfer rate constant (Kep) of healthy and different areas of necrotic femoral heads were measured on perfusion parameter maps. The differences and characteristics of these parameters in healthy and different areas of necrotic femoral heads were analyzed.ResultsThe signal accumulation in healthy femoral heads is lower than that of necrotic femoral heads in pseudocolor images. The time-signal intensity curve of healthy femoral heads is along the horizontal direction, while they all have upward trends for different areas of necrotic femoral heads. The mean value of Ktrans of healthy femoral heads was lower than the integration of necrotic, boundary, and other areas (F = 3.133, P = .036). The Kep value of healthy femoral heads was higher than the integration of lesion areas (F = 6.273, P = .001). The mean Ve value of healthy femoral heads was smaller than that of the lesion areas (F = 3.872, P = .016). The comparisons of parameters between different areas and comparisons among healthy areas and lesion areas showed different results.ConclusionONFH is a complex ischemic lesion caused by changes in local microcirculation. It mainly manifests as increased permeability of the vascular wall, blood stasis in the posterior circulation, high intraosseous pressure in the femoral head, and decreased arterial blood flow. The application of DCE-MRI scanning to quantitatively analyze the visual manifestations of microcirculation after early ONFH is an ideal method to study the microcirculation changes of necrotic femoral heads.
Balloon kyphoplasty as palliative care for painful pathological spinal fracture followed by lung cancer metastasis: A cohort study
Authors: Zhang Jun-xin , Song Zhuo-run , Zou Jun , Ge Jun , Yang Hui-lin 
Published: January 2023

BackgroundPathological spine fractures caused by metastases of lung cancer have brought great suffering to patients. Percutaneous kyphoplasty (PKP) has been considered a preferred alternative for painful spinal metastases. The clinical efficacy and safety of PKP for metastatic spinal lesions are urgently to be evaluated.MethodsA cohort study was conducted on 54 cases with pathologic spine fractures caused by metastasis of lung cancer. The correction of kyphosis was assessed by the Cobb angle. The life dependence and quality of the patients were evaluated by the Barthel Index of activities of daily living (ADL) and the quality-adjusted life year (QALY). Patients' survival was carefully recorded.ResultsPKP significantly corrected the kyphosis compared with conservative treatment. The ratio of moderate dependence after fracture was clearly increased by PKP. QALY indicated a better life quality brought by PKP. However, PKP could not improve the survival rate of patients.ConclusionPKP can be used as an effective palliative care treatment for patients with metastatic pathologic spinal fractures of lung cancer.
Prevalence of bovine viral diarrhea virus in cattle between 2010 and 2021: A global systematic review and meta-analysis
Authors: Su Nuo , Wang Qi , Liu Hong-Ying , Li Lian-Min , Tian Tian , Yin Ji-Ying , Zheng Wei , Ma Qing-Xia , Wang Ting-Ting , Li Ting , Yang Tie-Lin , Li Jian-Ming , Diao Nai-Chao , Shi Kun , Du Rui 
Published: January 2023

BackgroundBovine viral diarrhea is one of the diseases that cause huge economic losses in animal husbandry. Many countries or regions have successively introduced eradication plans, but BVDV still has a high prevalence in the world. This meta-analysis aims to investigate the prevalence and risk factors of BVDV in the world in recent 10 years, and is expected to provide some reference and theoretical basis for BVDV control plans in different regions.MethodRelevant articles published from 2010 to 2021 were mainly retrieved from NCBI, ScienceDirect, Chongqing VIP, Chinese web of knowledge (CNKI), web of science and Wanfang databases.Results128 data were used to analyze the prevalence of BVDV from 2010 to 2021. BVDV antigen prevalence rate is 15.74% (95% CI: 11.35–20.68), antibody prevalence rate is 42.77% (95% CI: 37.01–48.63). In the two databases of antigen and antibody, regions, sampling time, samples, detection methods, species, health status, age, sex, breeding mode, and seasonal subgroups were discussed and analyzed, respectively. In the antigen database, the prevalence of dairy cows in the breed subgroup, ELISA in the detection method subgroup, ear tissue in the sample subgroup, and extensive breeding in the breeding mode were the lowest, with significant differences. In the antibody database, the prevalence rate of dairy cows in the breed subgroup and intensive farming was the highest, with a significant difference. The subgroups in the remaining two databases were not significantly different.ConclusionThis meta-analysis determined the prevalence of BVDV in global cattle herds from 2010 to 2021. The prevalence of BVDV varies from region to region, and the situation is still not optimistic. In daily feeding, we should pay attention to the rigorous and comprehensive management to minimize the spread of virus. The government should enforce BVDV prevention and control, implement control or eradication policies according to local conditions, and adjust the policies in time.
Diet-Independent Positive Effects of a Multi-Species Probiotic on the Growth Performance and Resistance against Vibrio parahaemolyticus in White Leg Shrimp
Authors: Gruber Christina , Bui-Chau-Truc Dan , Kesselring Jutta C. , Nguyen Ngoc Diem , Standen Benedict , Wein Silvia 
Published: January 2023

Probiotic feed additives can support the gut health of shrimp and thereby improve performance, production efficiency and disease resistance. Two experiments in white leg shrimp aimed to investigate the effects of a multi-species probiotic feed supplement (AquaStar®, 3 g/kg feed, Biomin GmbH, Getzersdorf, Austria) in feed formulations with different marine meal levels (32% and 15%) on growth performance and resistance against Vibrio parahaemolyticus. Juvenile shrimp were stocked in a recirculating aquaculture tank system at a density of 20 shrimp/46.8 L and were fed diets with and without the probiotic supplementation for 8 weeks. Afterwards, a bath immersion with V. parahaemolyticus was performed and mortality was observed over a period of 14 days. Independent of the diet formulation, probiotic supplementation significantly improved the survival rate of the shrimp and the specific growth rate while decreasing feed consumption and feed conversion ratio when compared to the control (p ≤ 0.042). After the Vibrio immersion challenge, mortality was significantly decreased by 13.33% with probiotic supplementation in the high marine meal diet experiment (p = 0.042) and numerically decreased by 11.67% in the low marine meal diet experiment (p = 0.133). Overall, the results suggest that the beneficial effects of the probiotic can occur independently of the diet formulation.
Scale-Up of Pigment Production by the Marine-Derived Filamentous Fungus, Talaromyces albobiverticillius 30548, from Shake Flask to Stirred Bioreactor
Authors: Venkatachalam Mekala , Mares Gary , Dufossé Laurent , Fouillaud Mireille 
Published: January 2023

Talaromyces albobiverticillius 30548, a marine-derived fungus, produces Monascus-like azaphilone red/orange pigments which have the potential for various industrial applications. The objective of this study was to scale up pigment production in a 2 L bioreactor with a working volume of 1.3 L media and to compare its biomass growth and pigment production against small volume (500 mL) shake flasks with 200 mL working volume. Additionally, fungal morphology, pigment intensity, fermentation length and duration of pigment production were also compared. Experiments were carried out at laboratory scale in 200 mL shake flasks without controlling pH and oxygen. In parallel, fermentation was performed in a 2 L bioreactor as an initial scale-up to investigate the influence of dissolved oxygen, agitation speed and controlled pH on pigment production and biomass growth of T. albobiverticillius 30548. The highest orange and red pigment production in bioreactor at 24 °C was noticed after 160 h of fermentation (70% pO2) with 25.95 AU 470 nm for orange pigments and 22.79 AU 500 nm for red pigments, at pH set point 5.0. Meanwhile, the fermentation using 200 mL shake flasks effectively produced orange pigments with 22.39 AU 470 nm and red pigments with 14.84 AU 500 nm at 192 h under the same experimental conditions (24 °C, pH 5.0, 150 rpm). Regarding fungal morphology, growth of fungus in the bioreactor was in the form of pellets, whereas in the shake flasks it grew in the form of filaments. From the observed differences in shake flasks and closed bioreactor, it is known that the bioprocess was significantly influenced by dissolved oxygen saturation and agitation speed in scale-up. Thus, oxygen transfer appears to be the rate-limiting factor, which highly influences overall growth and production of pigments in Talaromyces albobiverticillius 30548 liquid culture.
GARUDAMUKHA LAŃCANA SEBAGAI SUMBER IDE PENCIPTAAN MOTIF BATIK TENUN UNTUK BUSANA CASUAL WANITA
Authors: Patras Idzah Risa Merita , Sudarwanto Aan 
Published: January 2023

Garudamukha Lancana merupakan cap atau lambang Kerajaan Kadiri pada masa Pemerintahan Raja Airlangga. Pada karya ini akan diwujudkan dengan teknik tenun ikat menggunakan pewarna indantren dengan teknik pewarnaan tutup celup. Untuk teknik batik tulis menggunakan pewarna remazol dengan teknik colet. Metode yang digunakan dalam perwujudan karya ini yaitu tahap eksplorasi, perancangan dan perwujudan. Luaran karya ini antara lain artikel (jurnal ilmiah), katalog serta karya busana casual wanita dengan judul Karyaning Jiwa Mardika (Kajika), dan menghasilkan motif yang berjudul Garudagni. Motif batik dan tenun disajikan dengan abstraksi objek garudamukha lancana yang menjadi sumber ide penciptaan dengan finishing menggunakan cat akrilik, sehingga menghasilkan karya yang bernilai dan estetis
PEMANFAATAN LIMBAH ANORGANIK
Authors: Ni'mah Ela Ayu , Susila Dwi Agus 
Published: January 2023

Limbah organik merupakan bentuk limbah yang dapat diurai kembali menjadi produk yang bermanfaat, baik secara kesehatan maupun secara ekonomi. Limbah anorganik juga dapat dimanfaatkan menjadi sesuatu yang bermanfaat pula, termasuk menambah pendapatan ekonomi jika dimanfaatkan secara maksimal. Hal ini terkait dengan program pemerintah yang mengangkat isu lingkungan hidup sebagai target pembangunan yang berkelanjutan dan akan bersinergi dengan departemen lainnya. Pada artikel ini menggunakan metode analisis data dua hal yaitu catatan lapangan dan dokumentasi. Diharapkan dua metode ini dapat mengumpulkan data yang efektif, efisien dan tepat sasaran, sehingga tujuan artikel ini dapat tercapai yaitu kemampuan untuk mengelola sampah botol plastik, sampah logam, sampah kain, sisa detergent, limbah pabrik menjadi produk yang kreatif dan bernilai ekonomis. Dengan demikian pengelolaan sampah anorganik ini diharapkan menjadi momentum bagi usia muda untuk mencintai lingkungan dimana ia tinggal sebagai sarana berprestasi dalam upaya peningkatan ekonomi kreatif.