bluuebunny/crossref_metadata_2025_split huggingface dataset:
Depression Assessment
Authors: Toukhsati Samia R , Yau Lewis , Yates Rosemary , Catrice Isabelle , Wasser Cory , Young Lynette , Greening Kimberley , Flaks Gabriella , Miller Jenna , Hare David L 
Published: September 2023

Background:
Patients are frequently assisted by proxies, usually a spouse, to complete health and medical surveys, including depression assessments.

Objective:
The objective of this study was to examine whether spousal assessments of patient depression concord with those of the patient.

Materials and Methods:
Consecutive adult cardiac patients attending an outpatient cardiovascular disease clinic accompanied by an adult were enrolled. Patient–spousal pairs independently completed the Cardiac Depression Scale (CDS) on behalf of the patient. Proxies provided demographic and medical history information and also completed the Physical Health Questionnaire.

Results:
A total of 72 patients (males 75%; mean age = 67.18 ± 11.35 years) and 72 spouses (mean age = 65.19 ± 11.49 years) met enrollment and analysis criteria. Most spouses were female (75%). Proxies rated patients significantly higher on the CDS (mean = 93.14 ± 29.33) than did patients of themselves (mean = 87.93 ± 26.79), t(71) = –2.05, P < 0.05. Patient–spousal concordance was low to moderate on the total CDS (concordance correlation coefficient [CCC] = 0.69) and CDS symptoms including mood (CCC = 0.35), anhedonia (CCC = 0.63), anxiety (CCC = 0.71), irritability (CCC = 0.55), hopelessness (CCC = 0.50), cognitive dysfunction (CCC = 0.41), and sleep disturbance (CCC = 0.64).

Conclusions:
These results suggest that spouses have limited insight into patient's psychological status, as self-reported by patients. Proxy assessments should be interpreted with caution and, wherever possible, patients should be encouraged to complete depression assessments on their own.
An in vitro Model for Experimental Evaluation of Sonothrombolysis under Tissue-mimicking Material Conditions
Authors: Drakos Theocharis , Evripidou Georgios , Damianou Christakis 
Published: September 2023

Background:
The mechanical properties of therapeutic ultrasound (US) have attracted scientific interest for thrombolysis enhancement in combination with thrombolytic agents and microbubbles (MBs). The aim of the study was to develop an in vitro model to observe how the effects of sonothrombolysis change in the case where a tissue-mimicking material (TMM) is placed in the path of the US beam before the clot.

Methods:
Fully retracted blood clots were prepared and pulse sonicated for 1 h under various conditions. The system was in a state of real circulating flow with a branch of an open bypass and an occluded tube containing a blood clot, thus mimicking the case of ischemic stroke. The effectiveness of thrombolysis was quantified in milligrams of clots removed. An agar-based TMM was developed around the occluded tube.

Results:
The clot breakdown in a TMM was found to be more pronounced than in water, presumably due to the retention of the acoustic field. A higher level of acoustic power was required to initiate clot lysis (>76 W acoustic power) using only focused US (FUS). The greatest thrombolysis enhancement was observed with the largest chosen pulse duration (PD) and the use of MBs (150 mg clot mass lysis). The synergistic effect of FUS in combination with MBs on the enzymatic fibrinolysis enhanced thrombolysis efficacy by 260% compared to thrombolysis induced using only FUS. A reduction in the degree of clot lysis was detected due to the attenuation factor of the intervening material (30 mg at 1 and 4 ms PD).

Conclusion:

In vitro thrombolytic models including a TMM can provide a more realistic evaluation of new thrombolytic protocols. However, higher acoustic power should be considered to compensate for the attenuation factor. The rate of clot lysis is slow and the clinical use of this method will be challenging.
An Online Educational Module to Improve General Internal Medicine Trainees’ Knowledge and Comfort in Managing Acute Complications of Sickle Cell Disease
Authors: Bhella Sita , Radwi Mansoor , Ward Richard 
Published: September 2023

BACKGROUND:
Sickle cell disease (SCD) is a genetic disorder characterized by hemolytic anemia and vaso-occlusive episodes. Many adults with SCD require hospitalization for the management of acute manifestations. There appears to be a gap in the level of knowledge that general internal medicine (GIM) trainees possess regarding the treatment and management of SCD.

METHODS:
We created an online module that helps medical residents improve their knowledge about SCD. Participants were exposed to different scenarios related to SCD. A pre-and posttests were administered to detect improvement in knowledge and comfort when managing SCD and its acute complications.

RESULTS:
Thirty consecutive GIM residents participated. Of these, 20 completed the demographic survey, 17 completed the pretest, and 10 completed the posttest and usability survey. The median time to complete the module was 68 min. Fifty percent of participants were 1st-year postgraduation from medical school. Forty-five percent stated that they were uncomfortable managing patients with SCD 80% had cared for at least 1–5 patients with SCD. All reported having no SCD lectures in residency. The median pretest score was 12/20 (range, 8–15) and posttest score was 20.5/25 (range, 13–24).

CONCLUSIONS:
Residents agreed that the module was useful, helps understanding about SCD and its complication, and aids with clinical duties. This module demonstrated to be an effective educational tool that can support resident education during their internal medicine. Further strategies will be needed to improve the delivery of online modules to keep residents engaged with the module and attaint full benefit from these activities.
Venous Thromboembolism Risk Assessment among Beta-thalassemia Patients
Authors: Abo-Elwafa Hasnaa A. , Youseff Laila M. , Mahmoud Ramadan A. , Elbadry Mahmoud I. , Tawfeek Ahmed , Aziz Shereen P. 
Published: September 2023

BACKGROUND:
Thromboembolic (TE) disorders are among the most common complications of beta-thalassemia. We designed this cross-sectional study to investigate the state of hypercoagulability and platelet activation in patients with beta-thalassemia.

PATIENTS AND METHODS:
Seventy-five patients diagnosed with beta-thalassemia by hemoglobin electrophoresis were divided into three groups of 25 patients each: Group I (thalassemia trait), Group II (thalassemia intermedia [TI]), and Group III (thalassemia major). In addition, 50 healthy individuals were included as controls. Both patients and control groups were subjected to clinical and laboratory assessment, which included measurement of protein C, anti-thrombin III, D-dimer, CD41, CD42, CD61, and CD62P, and detection of beta-chain mutations.

RESULTS:
Levels of the platelet activation marker CD62P were significantly higher in beta-thalassemia patients (26.28 ± 18.01%) than in controls (4.78 ± 2.27%) (P < 0.001). The D-dimer level was significantly higher in beta-thalassemia patients (348.41 ± 571.01 ng/mL) than in controls (71.6 ± 39.61 ng/mL) (P < 0.001). Protein-C and AT-III levels were significantly lower in beta-thalassemia patients (71.45 ± 13.26%, 78.38 ± 15.32%) in comparison with controls (94.9 ± 13.03%, 96.52 ± 11.01%) (P < 0.001 and P < 0.001, respectively). TE disorders were found in 7/25 (9%) beta-thalassemia patients, especially in older and postsplenectomy patients. TE was most commonly found in beta-TI. Beta-chain mutations were found in all patients with TE disorders, especially compound heterozygous intervening sequence (IVS) (IVS1.6 [T > C]/IVS1.110 [G > A]).

CONCLUSION:
Postsplenectomy teenagers and adults with beta-thalassemia with lower levels of natural anticoagulant in the blood, an increased level of D-dimer, and platelet activator factor had a significantly higher risk for TE than those with childhood beta-thalassemia and the control group. In comparison with other beta-thalassemia patients, TI with beta-chain mutations is more likely to develop TE.
Incidence of Lymphoma Among Adult Patients in the Eastern Province of Saudi Arabia – A Single-center Study
Authors: Al-Ansari Rehab Yusuf , Aljarah Nasser Mohammed , Alofi Ghufran Moaid , Shaigah Faisal Ahmed Abu , Al-Qahtany Faisal Hani , Jebakumar Arulanantham Zechariah , Alsubaie Saad Mohammed , Al-Almaie Saad Mohammed , Qureshi Arifa Jamaluddin 
Published: September 2023

BACKGROUND:
Lymphoma is a cancer of the lymphatic system with two main types, namely Hodgkin lymphoma (HL) and non-HL (NHL). Within these, there are many subtypes. Based on data from the National Cancer Institute, NHL accounts for 4.2% whereas HL accounts for 0.5% of all cancers in the United States. The treatment strategy depends on the type and the stage of the lymphoma. In this study, we are studying the incidence rate of lymphoma in a military-nononcology center for better understanding and recording of the condition.

METHODS:
We conducted an observational, analytical, retrospective study in a tertiary care hospital on 56 patients admitted to the hospital between January 2016 and the end of December 2021, with lymphadenopathy or body mass, who were diagnosed with lymphoma. The modality of diagnosis was tissue histopathology. All data including demographics, details of lymphoma lesions, and laboratory and histopathology results were obtained from health informatics or manual records.

RESULTS:
In this study, we found that 67.9% of the cases were male, with a significantly higher rate among Saudi patients in comparison to non-Saudi (94.6% and 5.3%, respectively). Among Saudi cases, we found that a significantly higher percentage of lymphoma cases were originally from the Eastern and the Southern provinces (47.1% and 35.8%, respectively), and 46.5% of them were living in Dammam at the time of diagnosis. The percentage of NHL was significantly higher than Hodgkin type (80.3% and 19.6%, respectively). The majority of the cases belonged to B-cell NHL (73.2%). Moreover, the incidence rate increased from 2016 to 2021 with an accumulative rate of 25.14 / 100,000 person-years.

CONCLUSION:
Our data indicate that the incidence rate of lymphoma increased in the last 5 years at a tertiary care center. We found evidence for associations between the original province and the rate of the lymphoma. Moreover, the rate of B-cell NHL was significantly higher with superior mortality rate in comparison to other types of lymphoma in our cohort, which supported previous studies in the Kingdom of Saudi Arabia. There was no increase in incidence of lymphoma in our study cohort of military personnel, and it matches the incidence data of other local studies. Further national studies and initiation of lymphoma registry may add a value for future researches.
Myxedema crisis in an adolescent girl, successfully treated by oral thyroxine: A case report
Authors: Tandon Rahul , Kumar Amit , Patel Shradha , Mori Sandip , Thakkar Fenil , Tandon Krutika 
Published: September 2023

Abstract
Myxedema crisis is a condition with high mortality. It affects adults more often than children. Patients present with low blood pressure, low pulse, low body temperature, hypoventilation, and gastrointestinal dysfunction. Here, we present a case report of a teenage girl who was diagnosed with acquired hypothyroidism at the age of 7 years and was effectively treated with oral thyroxine in myxedema crisis.
Coronavirus disease 2019 pneumonia with acute respiratory distress syndrome in a child requiring prolonged mechanical ventilation: A case report
Authors: Sunthwal Shraddha , Lad Sagar , Bafna Sanjay , Kulkarni Rajesh , Lad Preeti , Ahmadi Salma , Ganacharya Raj 
Published: September 2023

Abstract
Coronavirus disease 2019 (COVID-19) infection in children predominantly presents with milder symptoms and is apparently less severe. However, 2% of acute pediatric COVID-19 cases possessed severe manifestations. Here, we describe a case study of a 4-year-old boy suffering from acute COVID-19 infection that presented like an adult ARDS requiring prolonged ventilation and medical course complicated with hospital-acquired infection and thrombosis which is very rarely seen. After 45 days of mechanical ventilation, the child was successfully weaned off from ventilatory support. Notably, analysis of the current literature revealed that this represents the longest reported hospitalization and ventilation period for a child presenting with COVID-19 pneumonia with potential complications. It highlights the importance of allowing sufficient time for clinical interventions to take effect, even when the prognosis appears poor. Hence, treating physicians should be aware of this atypical presentation.
Simplified scoring system to predict outcome in pediatric patients admitted through emergency department from a tertiary care teaching hospital of North India
Authors: Gupta Prakhar , Kumari Anita , Bhatnagar Ruchika , Aggarwal Kanika , Ruby  
Published: September 2023

Abstract

Background:
Estimating the morbidity and mortality in the emergency department (ED) only allows the pediatricians to assess the prognosis of the patient and plan therapies accordingly. This study was conducted to develop and validate a simple scoring system and establish a correlation between clinical parameters and the outcome of the patient.

Subjects and Methods:
Nine parameters, i.e., body temperature, respiratory rate, heart rate, blood pressure (BP), pulse oxygen saturation (SpO2), capillary refill time, level of sensorium, presence of seizure, and random blood sugar level, were documented, at the time of admission. Parameters were assigned a score of “0” if it is normal. An abnormality in the above parameters were indicated by a score ranging from 1 to 3. The primary outcome was assessed in terms of death/survival.

Results:
Out of the total, 57.2% required critical care, and mortality was reported in 14.75% of cases. On univariate analysis, seven clinical parameters were significantly associated with mortality. In multivariate logistic regression analysis, abnormalities in BP, SpO2, and temperature were independent predictors of mortality (P < 0.05). The receiver operating characteristic was 0.798 (95% confidence interval, 0.755–0.836; P < 0.0001) for the outcome of mortality (the predictive ability of score of 79.8%). The patients with scores 1–5, 6–10, and >10 had 4.923, 23.143, and 112.0 higher odds of mortality, respectively.

Conclusions:
This scoring system predicts the severity of illness and outcome with a sensitivity of 71.19% and specificity of 72.14%, respectively, in the ED. Higher scores predict unfavorable outcomes in these children.
IMPLEMENTATION OF E-GOVERNMENT ON THE E-ORDER SYSTEM TO INCREASE MICRO, SMALL, AND MEDIUM ENTERPRISES IN SOUTH JAKARTA
Authors: Asmiyanti Reny 
Published: September 2023

Study this aims for identify and understand urgency management application e-Order or online market for goods and services public for speed up SMEs growth in DKI Jakarta Province. The program aims to increase growth economy and opportunity work for SMESs DKI Jakarta Province with provide marketing online. Website development is one of the political str(web and development strategy e-government national , that is implementation systematic development _ through realistic and measurable steps _ Government website development area is the first from four layers ( web presence , interaction , transaction and transformation / integration ) within stages development Indonesian e-government for possible Indonesian people with easy access information government area and participate in development Indonesian democracy through online media. This study use approach qualitative through interviews and studies library, this showing several thing that is first System application e-Order this is breakthrough innovative BPPBJ (Service Agency Procurement Goods and Services) Government DKI Jakarta Province Second, System Application e-Order is connecting application _ activity purchase SMES products (as supplier) with agency government province in DKI Jakarta.System building e-Order this is form cooperation Among Provincial government DKI Jakarta with citizen. DKI Jakarta residents can participate direct in the development process Technology Industry 4.0 DKI citizens must be IT -based care with IT progress, SMEs can develop marketing and owning quality more product _ fine, however permanent notice factor effective and efficient from use system e-government.
Reaction dynamics of P(4S) + O2(X3Σ−g)  →  O(3P) + PO(X2Π) on a global CHIPR potential energy surface of PO2(X2A1): implications for atmospheric modelling
Authors: Chen Guangan , Qin Zhi , Li Ximing , Liu Linhua 
Published: September 2023

Abstract. The reaction dynamics of P(4S) + O2(X3Σg-) → O(3P) + PO(X2Π) are thought to be important in atmospheric and interstellar chemistry. Based on the state-of-the-art ab initio energy points, we analytically constructed a global potential energy surface (PES) for the ground-state PO2(X2A1) using the combined-hyperbolic-inverse-power-representation (CHIPR) method. A total of 6471 energy points were computed by the multireference configuration interaction method with the Davidson correction and aug-cc-pV5Z basis set. The analytical CHIPR PES reproduces ab initio energies accurately with a root-mean-square deviation of 91.5 cm−1 (or 0.262 kcal mol−1). The strongly bound valence region of the PES has complicated topographical features with multiple potential wells and barriers. The attributes of the important intermediates are carefully validated with our geometry optimization results, as well as previous experimental and computational results. Finally, the reaction probability, integral cross sections, and rate constants for P(4S) + O2(X3Σg-) → O(3P) + PO(X2Π) are calculated using the quasi-classical trajectory and time-dependent wave packet methods. The trends of probability and integral cross section versus the collision energy can be divided into three stages, which are governed by the entrance barriers or exothermicity of the reaction. The rate constant demonstrates strong Arrhenius linear behaviour at relatively low temperatures but deviates from this pattern at high temperatures. The calculated cross sections and rate constants are helpful for modelling the phosphorus chemistry in atmospheric and interstellar media.
Les victimes de la Covid-19 au Burkina Faso et la construction d’une rhétorique de polarisation dans la presse écrite
Authors: SAWADOGO Issaka 
Published: September 2023

The Victims of COVID-19 in Burkina Faso and the Emergence of a Polarizing Discourse in Written Press
ABSTRACT: The objective of this study is to demonstrate the conflict between the victims of covid-19 through their written discours depending on whether these people are socially important or not,(politically or regiously). Through argumentation theory (Amossy 2016 ; Koren and Amossy 2002), it emerges that the discourse of victims of the disease is a polarized discours.
RESUME : L’objectif de la présente étude, c’est à partir des productions des personnes victimes de la covid-19 relayées dans la presse, de rechercher l’aspect polémique du discours selon que ces victimes occupent une position socialement haute (autorités politiques ou religieuses) ou une position socialement moyenne (n’assumant pas d’autorité politique ou religieuse). Dans une approche qui convoque l’analyse de l’argumentation dans le discours (Amossy 2016 ; Koren & Amossy 2002), la présente étude démontre que le discours des patients associe des procédés impliquant divers procédés linguistiques dans une logique de polarisation.
Patient Satisfaction with Same-Day Discharge after Urogynecologic Surgery during the COVID-19 Pandemic
Authors: Alsup Kendall , McElhone Peyton , Henley Barbara , Boyd Walker , Makami Camelia , Roberson Donnyell , Lanzer Jennifer 
Published: September 2023

Background Patient satisfaction with same-day discharge after apical prolapse surgery has not been studied in the setting of the COVID-19 pandemic. Widespread implementation of same-day discharge for urogynecologic procedures has the potential to decrease hospital crowding, cost to patients, and the potential risks of in-patient stays, which are especially important to consider amid an ongoing pandemic. This study aims to investigate patient satisfaction with same-day discharge after minimally invasive urogynecologic surgery for apical vaginal prolapse during the COVID-19 pandemic. Patients and Methods All patients undergoing apical prolapse surgery at a single academic institution during the COVID-19 pandemic from March 2020 to December 2021 were queried using applicable CPT codes. In this observational cohort study, each participant was surveyed by phone. The validated Surgical Satisfaction Questionnaire (SSQ-8) was used to assess general satisfaction with the surgical experience, and additional questions were asked to assess the impact of the COVID-19 pandemic on patient satisfaction. Results One hundred and twenty-six patients met inclusion criteria and 60 patients (47.6%) chose to participate in the study. SSQ-8 scores revealed high overall satisfaction with the surgical experience (34.7 ± 5.7 out of 40). The majority of patients, 43 (71.7%), found that the ongoing COVID-19 pandemic had “no impact” on their surgical satisfaction. Conclusions Same-day discharge after surgery for apical vaginal prolapse is regarded as highly satisfactory and safe by the majority of patients. Overall, the COVID-19 pandemic had no impact on patient satisfaction with same-day discharge after urogynecologic surgery at our institution.
Investigating of Lecturers and Learners Foreign Language Anxiety in E- Learning Interaction
Authors: Sadapotto Andi , T Syamsu , Usman Usman , Darmiani Darmiani , Nadirah Nadirah , . Sam Hermansyah 
Published: September 2023

The objectives of the research are to know the anxiety of the lecturers and the learners foreign language anxiety in E- learning interaction , The subjects of this study were students of muhammadiyah Sidenreng Rappang University consisting 21 students as a sample from fourth semester of English departement and 5 English lecturers of muhammadiyah Sidenreng Rappang University. The qualitative research method was used in this study. Questionnaires and interviews were used to collect data. Based on the results of the questionnaire and interviews with subjects, the factors of students' anxiety in speaking English are classified into three major types of anxiety, namely test anxiety, communicative apprehension, and fear of negative evaluation.
Keywords :Foreign language learner, lecturer ,anxiety, E-Learning