bluuebunny/crossref_metadata_2025_split huggingface dataset:
Resveratrol and Dulaglutide ameliorate adiposity and liver dysfunction in rats with diet-induced metabolic syndrome: Role of SIRT-1 / adipokines / PPARγ and IGF-1
Authors: Shamardl Hanan Abdel Moneam A. , Ibrahim Noha A. , Merzeban Dina H. , Elamir Azza M. , Golam Rehab M. , Elsayed Asmaa M. 
Published: March 2023

Abstract

Background
Adiposity and non-alcoholic fatty liver disease (NAFLD) are common characteristics of metabolic syndrome (MS). Understanding the underlying pathogenesis is crucial for the development of new remedies. Resveratrol controls obesity and glycemic disorders in patients with MS.

Objectives
This study aimed to evaluate the effect of resveratrol and dulaglutide on adipose tissues and liver in rats with MS, declaring their possible mechanisms.

Methods
Rats allocated as Control, MS (induced by a high fat/ high sucrose diet for eight weeks), MS + Resveratrol (30 mg/kg/day orally), and MS + Dulaglutide (0.6 mg/kg twice weekly SC); drugs administration was in the last four weeks. Serum biochemical measurements were done. Liver and visceral fat were processed for biochemistry, histopathology, and immunohistochemistry.

Results
MS results demonstrated significantly increased systolic and diastolic blood pressure, anthropometric measurements, serum levels of alanine aminotransferase (ALT), glycemic indices, and lipids with decreased HDL-C. Tissue levels of leptin, malondialdehyde (MDA), and TNF-α reactivity significantly increased. Expression of adiponectin, PPARγ, and insulin growth factor-1 (IGF-1) decreased. Also, Western blotting mRNA gene expression of liver SIRT-1 was down-regulated. Resveratrol and dulaglutide significantly and effectively reversed MS complexity, ameliorating all findings, particularly NAFLD and adiposity-induced inflammation. Resveratrol significantly appears superior to dulaglutide regarding the effects on hemodynamics, lipids, adipokines, IGF-1 levels, and adipocyte size. Parallel, dulaglutide has more influence on glycemic control.

Conclusion
Protective effects of the drugs may be through correlations between SIRT-1/adipokines/IGF-1 and PPARγ, improving the cross-talk between insulin resistance, obesity markers, liver dysfunction, and TNF-α. Promising multi-beneficial therapies of resveratrol or dulaglutide in MS are recommended clinically for this purpose.

Graphical Abstract
Showing the Experimental Design
Interventions to Reduce Exposure to Synthetic Phenols and Phthalates from Dietary Intake and Personal Care Products: a Scoping Review
Authors: Yang Tiffany C. , Jovanovic Nicolas , Chong Felisha , Worcester Meegan , Sakhi Amrit K. , Thomsen Cathrine , Garlantézec Ronan , Chevrier Cécile , Jensen Génon , Cingotti Natacha , Casas Maribel , McEachan Rosemary RC , Vrijheid Martine , Philippat Claire 
Published: March 2023

Abstract
Purpose of Review
A scoping review was conducted to identify interventions that successfully alter biomarker concentrations of phenols, glycol ethers, and phthalates resulting from dietary intake and personal care product (PCPs) use.

Recent Findings
Twenty-six interventions in populations ranging from children to older adults were identified; 11 actively removed or replaced products, 9 provided products containing the chemicals being studied, and 6 were education-only based interventions. Twelve interventions manipulated only dietary intake with a focus on bisphenol A (BPA) and phthalates, 8 studies intervened only on PCPs use and focused on a wider range of chemicals including BPA, phthalates, triclosan, parabens, and ultraviolet absorbers, while 6 studies intervened on both diet and PCPs and focused on phthalates, parabens, and BPA and its alternatives. No studies assessed glycol ethers. All but five studies reported results in the expected direction, with interventions removing potential sources of exposures lowering EDC concentrations and interventions providing exposures increasing EDC concentrations. Short interventions lasting a few days were successful. Barriers to intervention success included participant compliance and unintentional contamination of products.

Summary
The identified interventions were generally successful but illustrated the influence of participant motivation, compliance, ease of intervention adherence, and the difficulty of fully removing exposures due their ubiquity and the difficulties of identifying “safer” replacement products. Policy which reduces or removes EDC in manufacturing and processing across multiple sectors, rather than individual behavior change, may have the greatest impact on population exposure.
An instance-based deep transfer learning method for quality identification of Longjing tea from multiple geographical origins
Authors: Zhang Cheng , Wang Jin , Yan Ting , Lu Xiaohui , Lu Guodong , Tang Xiaolin , Huang Bincheng 
Published: March 2023

AbstractFor practitioners, it is very crucial to realize accurate and automatic vision-based quality identification of Longjing tea. Due to the high similarity between classes, the classification accuracy of traditional image processing combined with machine learning algorithm is not satisfactory. High-performance deep learning methods require large amounts of annotated data, but collecting and labeling massive amounts of data is very time consuming and monotonous. To gain as much useful knowledge as possible from related tasks, an instance-based deep transfer learning method for the quality identification of Longjing tea is proposed. The method mainly consists of two steps: (i) The MobileNet V2 model is trained using the hybrid training dataset containing all labeled samples from source and target domains. The trained MobileNet V2 model is used as a feature extractor, and (ii) the extracted features are input into the proposed multiclass TrAdaBoost algorithm for training and identification. Longjing tea images from three geographical origins, West Lake, Qiantang, and Yuezhou, are collected, and the tea from each geographical origin contains four grades. The Longjing tea from West Lake is regarded as the source domain, which contains more labeled samples. The Longjing tea from the other two geographical origins contains only limited labeled samples, which are regarded as the target domain. Comparative experimental results show that the method with the best performance is the MobileNet V2 feature extractor trained with a hybrid training dataset combined with multiclass TrAdaBoost with linear support vector machine (SVM). The overall Longjing tea quality identification accuracy is 93.6% and 91.5% on the two target domain datasets, respectively. The proposed method can achieve accurate quality identification of Longjing tea with limited samples. It can provide some heuristics for designing image-based tea quality identification systems.
p-adic vertex operator algebras
Authors: Franc Cameron , Mason Geoffrey 
Published: March 2023

AbstractWe postulate axioms for a chiral half of a nonarchimedean 2-dimensional bosonic conformal field theory, that is, a vertex operator algebra in which a p-adic Banach space replaces the traditional Hilbert space. We study some consequences of our axioms leading to the construction of various examples, including p-adic commutative Banach rings and p-adic versions of the Virasoro, Heisenberg, and the Moonshine module vertex operator algebras. Serre p-adic modular forms occur naturally in some of these examples as limits of classical 1-point functions.
50 Jahre „Unterrichtswissenschaft – Zeitschrift für Lernforschung“ – Jubiläumsheft I
Authors: Gräsel Cornelia , Hardy Ilonca , Hertel Silke , Kleickmann Thilo , Moser Opitz Elisabeth , Neumann Knut , Praetorius Anna-Katharina , Renkl Alexander , Wirth Joachim 
Published: March 2023

ZusammenfassungDie Unterrichtswissenschaft feiert ein Jubiläum – sie erscheint im Jahr 2023 seit 50 Jahren. Dieser Beitrag ist die Einführung für das Jubiläumsheft (Heft 1, 2023). Er stellt zunächst die Gründung der Zeitschrift dar. Anhand der Protokolle der Herausgebersitzungen wird skizziert, wie sich die „Unterrichtswissenschaft“ als Zeitschrift der empirischen Lehr-Lernforschung entwickelt hat und welche Herausforderungen dabei zu bewältigen waren. Abschließend werden die bisherigen Überlegungen der derzeitigen Herausgeber*innen für die Entwicklung der Zeitschrift und der Lehr-Lern-Forschung vorgestellt.
Synthesis, structure, morphology, magnetism, and magnetocaloric-effect studies of (La1−xPrx)0.7Sr0.3MnO3 nanocrystalline perovskites
Authors: Al-Shahumi Turkiya M. , Al-Omari Imaddin A. , Al-Harthi Salim H. , Myint Myo Tay Zar 
Published: March 2023

AbstractSingle-Phase (La1–xPrx)0.7Sr0.3MnO3 (x = 0.0, 0.2, 0.4, 0.6, 0.8, and 1.0) perovskites were synthesized by the sol–gel method followed by sintering at 700 °C for 5 h. Samples with x = 0.0–0.4 are found to crystallize into rhombohedral structure (R-3c space group) while the ones with x = 0.6–1.0 crystallize into orthorhombic structure (Pbnm space group). The average particle size of the samples was in the range of 21–44 nm. All samples exhibit a ferromagnetic to paramagnetic second-order magnetic phase transition at Curie temperature, which is found to decrease linearly with increasing the Pr concentration. The magnetic coercivity was found to be small (~ 10 Oe) for all the samples, at T < TC. The experimental effective paramagnetic moment (µeff) is found to increase with increasing x from 3.99 µB (x = 0.0) to 5.05 µB (x = 1.0). The magnitude of the maximum magnetic entropy change (−ΔSM)max. and the relative cooling power (RCP) for the samples having orthorhombic structure increases as x increases reaching a maximum value of 4.67 J/kg.K and 574 J/kg at ΔµoH = 9 T for x = 1.0. While the ones with the rhombohedral structure have the maximum values of (−ΔSM)max. and RCP of 4.63 J/kg.K and 472 J/kg at ΔµoH = 9 T are for x = 0.2. The large values of (−ΔSM)max. and RCP (at room temperature (RT)) and the wider temperature range of −ΔSM for the sample with x = 0.6 suggests that this compound may be considered as magnetic refrigerant material at RT, and the other compounds can be candidates in the vicinity of RT.
The Cardiovascular Profile Score in Patients with Non-immune Hydrops Fetalis and Cardiac Anomalies — a Pilot Study
Authors: Dionysopoulou Anna , Pirih Etienne , Macchiella Doris , Fruth Anja , Jahn-Eimermacher Antje , Kampmann Christoff , Mildenberger Eva , Whybra Catharina 
Published: March 2023

AbstractThe purpose of this paper is to explore whether the cardiovascular profile score (CVPS) correlates with fetal outcome in patients with non-immune hydrops fetalis (NIHF) and cardiac anomalies. In this retrospective study, we included fetuses with NIHF and the suspicion of a cardiac anomaly in prenatal ultrasound. The CVPS was calculated using information obtained by fetal echocardiographic examination. Feto-neonatal mortality (FNM) was defined as intrauterine fetal demise or death in the first 6 months of life. We reviewed 98 patients, who were referred to the Department of Obstetrics and Gynecology of the Johannes Gutenberg University in Mainz with the diagnosis of NIHF between January 2007 and March 2021. By eighteen of them, the suspicion of a cardiac anomaly was raised. After exclusion of six pregnancies (one termination of pregnancy and five because of incomplete data), 12 cases were left for analysis. Mean gestational age at which the CVPS was calculated was 29 + 2 weeks. Two fetuses died in utero. Of the remaining ten hydropic fetuses, three newborns died in the neonatal period, and seven survived after a 6-month surveillance period. Median CVPS of all fetuses was 6 points. Surviving fetuses showed statistically significantly higher CVPS values (median 8 points) than fetuses with FNM (median 5 points, p value = 0.009). Our results point towards a positive association between CVPS and fetal outcome in fetuses with NIHF and cardiac anomalies. The CVPS appears to be a useful marker in the assessment of heart failure in utero.
Graphical Abstract
Update zur medikamentösen Therapie der Colitis ulcerosa
Authors: El Hadad Jasmina , Schreiner Philipp , Greuter Thomas 
Published: March 2023

ZusammenfassungDas Armamentarium an Therapeutika zur Behandlung der Colitis ulcerosa (CU) wird laufend erweitert. Die Biologika-Klasse dürfte in Kürze um die selektiven Anti-IL23 anwachsen. Selektive JAK-1-Inhibitoren stehen ebenfalls kurz vor der Zulassung. Zudem ist mit dem S1P-Agonisten Ozanimod seit Herbst 2022 das zweite orale „small molecule“ auf dem Markt. Für die etablierten Biologika sind zahlreiche günstigere Biosimilars verfügbar, und die subkutanen Formen von Infliximab und Vedolizumab werden die intravenöse Therapie über kurz oder lang wohl ganz verdrängen. Der/die klinisch tätige Gastroenterologe/-in, zusammen mit dem/der Patienten/-in, steht vor der schwierigen Herausforderung, wo und wie die neuen Präparate, die einander bislang in der Indikationsstellung nicht überlegen sind, im Therapiealgorithmus zu positionieren sind. Publizierte und laufende Head-to-head-Vergleiche werden in diesem Entscheidungsprozess helfen. Nutzen und Nebenwirkungen einer Therapie sowie patientenspezifische Präferenzen (Applikationsform) sind gegeneinander abzuwägen, dies insbesondere, solange noch keine spezifischen Tests vorliegen, welche das Therapieansprechen voraussagen. Schliesslich könnten Kombinationsformen verschiedener Biologika in Zukunft zu höheren Ansprechraten führen (wie die Kombinationstherapie des Anti-TNF Golimumab und des selektiven Anti-IL23 Guselkumab in der Phase-2a-VEGA-Studie), wobei dies in laufenden und geplanten Studien zu zeigen ist.
The Archer and the Shield-Bearing Warrior
Authors: Loendorf Lawrence L. , Steelman Karen L. , Castañeda Amanda M. 
Published: March 2023

AbstractAt the Painted Coulee site (24JT86), pictographs depicting both atlatl and bow technology are present. We utilized plasma oxidation followed by accelerator mass spectrometry to directly radiocarbon date the organic material in two paint samples. A red painting of an anthropomorph with a shield and a possible atlatl in conflict with a fleeing person holding a bow was dated to 1790 ± 50 RCYBP (cal AD 120–390). Another red anthropomorph wearing snowshoes and holding a bow was dated to 1710 ± 45 RCYBP (cal AD 240–425). Radiocarbon dates for underlying oxalate minerals provided maximum ages for the paintings that are consistent with the direct ages. This early example of Plains Biographic rock art is significant because it illustrates a scene between a Late Archaic shield-bearing warrior with a possible atlatl and an anthropomorph with a bow and arrow at a time when bows first came into use on the Northwestern Plains.
Advances in data availability to constrain and evaluate frontal ablation of ice-dynamical models of Greenland's tidewater peripheral glaciers
Authors: Recinos Beatriz , Maussion Fabien , Marzeion Ben 
Published: March 2023

AbstractWe revise and evaluate frontal ablation fluxes obtained by the Open Global Glacier Model (OGGM) for Greenland's tidewater peripheral glaciers de-coupled from the ice sheet. By making use of new region-wide ice thickness and solid ice discharge data, we re-evaluate model performance and suggest future research directions to improve the ice thickness estimation of glacier models. OGGM is unable to predict individual tidewater glacier dynamics well if it has to rely only on surface mass balance estimates and the assumption of a closed budget to constrain the calving parameterization. Velocity observations are essential to constrain the model and estimate the dynamic mass loss of Greenland's tidewater peripheral glaciers.
Falsehoods, Foreign Interference, and Compelled Speech in Singapore
Authors: Chng Kenny 
Published: March 2023

AbstractOnline misinformation endangers the infrastructure of fact essential to public discourse and presents an even greater threat where it is being utilised as a weapon by hostile state actors. In recognition of these dangers, Singapore has implemented legal measures to combat online misinformation, enacting in quick succession the Protection from Online Falsehoods and Manipulation Act (POFMA) and the Foreign Interference (Countermeasures) Act (FICA). These statutes open up novel frontiers of development for Singapore's free speech jurisprudence. Indeed, these statutes confer upon government authorities the power to compel the authors of certain material to display notices stating that the material contains falsehoods or originated from a hostile information campaign. Yet, should one accept that the constitutional right to freedom of speech extends to the freedom not to speak, the compulsion of such expressions may well be unconstitutional under Singapore's free speech guarantee. This article will study the theoretical justifications for a prohibition against compelled speech to evaluate whether Singapore free speech jurisprudence ought to recognise such a prohibition, propose a doctrinal framework to analyse compelled expressions by reference to US, UK, and Canadian jurisprudence, and critically assess how the POFMA and FICA would fare under such a doctrine.
Intimate Exposure: A Feminist Phenomenology of Sexual Experience and Sexual Suppression
Authors: Hoff Shannon 
Published: March 2023

AbstractAccounts of sexual experience, sexual oppression, and sexual violation, if they are not to lend support to the problems they are invoked to address, require the foundation of a phenomenological description of the character of experience. Relying on Maurice Merleau-Ponty, I aim to provide this foundation, arguing that sexual experience is a domain not of detached, individual autonomy but of intrinsic susceptibility and exposure to the world. My description of sexual experience is intended to reveal the immanent norms that sexuality projects and thereby to critique ways of inhabiting experience that disavow what is revealed in that description. The first section discerns three ambiguities that characterize our experience in Merleau-Ponty's notion of “flesh”: that between materiality and meaning, self and others, and self and world. The second section offers a phenomenology of sexual experience based on these ambiguities. The third section, on sexual oppression and suppression, identifies two stereotypical ways in which they are evaded: what I call the stances of “withdrawal from” and “control of” sexuality as flesh. Finally, the fourth section reveals the shortcomings of the legal-juridical domain in navigating our status as flesh, and warns against the proliferation of its terms, specifically the norm of consent.
Using clinical decision support to improve urine testing and antibiotic utilization
Authors: Yarrington Michael E. , Reynolds Staci S. , Dunkerson Tray , McClellan Fabienne , Polage Christopher R. , Moehring Rebekah W. , Smith Becky A. , Seidelman Jessica L. , Lewis Sarah S. , Advani Sonali D. 
Published: March 2023

AbstractObjective:Urine cultures collected from catheterized patients have a high likelihood of false-positive results due to colonization. We examined the impact of a clinical decision support (CDS) tool that includes catheter information on test utilization and patient-level outcomes.Methods:This before-and-after intervention study was conducted at 3 hospitals in North Carolina. In March 2021, a CDS tool was incorporated into urine-culture order entry in the electronic health record, providing education about indications for culture and suggesting catheter removal or exchange prior to specimen collection for catheters present >7 days. We used an interrupted time-series analysis with Poisson regression to evaluate the impact of CDS implementation on utilization of urinalyses and urine cultures, antibiotic use, and other outcomes during the pre- and postintervention periods.Results:The CDS tool was prompted in 38,361 instances of urine cultures ordered in all patients, including 2,133 catheterized patients during the postintervention study period. There was significant decrease in urine culture orders (1.4% decrease per month; P < .001) and antibiotic use for UTI indications (2.3% decrease per month; P = .006), but there was no significant decline in CAUTI rates in the postintervention period. Clinicians opted for urinary catheter removal in 183 (8.5%) instances. Evaluation of the safety reporting system revealed no apparent increase in safety events related to catheter removal or reinsertion.Conclusion:CDS tools can aid in optimizing urine culture collection practices and can serve as a reminder for removal or exchange of long-term indwelling urinary catheters at the time of urine-culture collection.
Large hospital-wide outbreak of Paenibacillus spp pseudobacteremia associated with contaminated nonsterile gloves
Authors: Sorio Guilherme Geraldo Lovato , Arns Beatriz , Kawski Cristiane Tejada da Silva , Gleit Patricia Machado , Flores Gabriela Pereira , Martins Erik Menezes , Gorges Muriel , Klafke Renata Dortzbacher Feil , Alves Marcelle Duarte , Magagnin Cibele Massotti , Sampaio Jorge Luiz Mello , Zavascki Alexandre Prehn 
Published: March 2023

AbstractWe report a large, hospital-wide outbreak of pseudobacteremia by Paenibacillus spp. In total, 139 patients presented at least 1 positive blood culture during a 13-month period. Microbiological experiments indicated that contaminated nonsterile gloves were associated with the pseudobacteremia episodes. The outbreak was resolved by discontinuing the use of the involved brand.
Physical Violence and Social Tension in the Atacama Desert: Osteobiography of a Woman from the Tarapacá 40 Formative Period Cemetery
Authors: Herrera-Soto María José , González-Ramírez Andrea , Díaz Pablo , Pacheco Aryel , Retamal Rodrigo , Sáez Arturo , Santana-Sagredo Francisca , Uribe Mauricio 
Published: March 2023

AbstractPhysical violence and social conflict have been widely studied in the ancient societies of the Andes. However, studies about violence are scarce for the Formative period of northern Chile (1000 BC–AD 900). Evidence from these investigations is generally interpreted as interpersonal violence, whose protagonists are mostly men. Here, we present the case of an adult female recovered from the Tarapacá 40 cemetery (Tarapacá region, Chile) displaying lesions suggestive of trauma. We reconstruct her life and death in the context of this era's social and political conditions. Results of our bioanthropological characterization, cranial trauma analysis, carbon and nitrogen isotope analysis, and recording of the funerary offerings suggest she was a local member of the Formative community buried in the Tarapacá 40 cemetery and that she suffered intentional lethal lesions. Her death is unusual because there are no previous bioarchaeological records of lethal violence against women in the Tarapacá region. The osteobiography of this woman reflects a context characterized by an increase in inequality and social complexity, whereby physical violence could be used as a mechanism of internal regulation and exercise of power during the Formative period.