bluuebunny/crossref_metadata_2025_split huggingface dataset:
Input reduction for nonlinear thermal surface loads
Authors: Rother Stephan , Beitelschmidt Michael 
Published: February 2023

AbstractA multiplicity of simulations is required to optimize systems with thermal transient processes in the presence of uncertain parameters. That is why model order reduction is applied to minimize the numerical effort. The consideration of heat radiation and convection with parameter-dependent heat transfer coefficients results in a nonlinear system with many inputs as these loads are distributed over the whole surface limiting the attainable reduced dimension. Therefore, a new input reduction method is presented approximating the input matrix based on load vector snapshots using singular value decomposition. Afterward, standard reduction methods like the Krylov subspace method or balanced truncation can be applied. Compared to proper orthogonal decomposition, the number of training simulations decreases significantly and the reduced-order model provides a high accuracy within a broad parameter range. In a second step, the discrete empirical interpolation method is used to limit the evaluation of the nonlinearity to a few degrees of freedom and proper orthogonal decomposition allows the fast adaptation of the emissivity. As a result, the reduced system becomes independent of the original dimensions and the computation time is reduced drastically. This approach enables an optimal method combination depending on the number of simulations performed with the reduced model.
KRAS codon 12 mutations characterize a subset of de novo proliferating “metaplastic” Warthin tumors
Authors: Agaimy Abbas , Mantsopoulos Konstantinos , Iro Heinrich , Stoehr Robert 
Published: February 2023

AbstractWarthin tumor (WT; synonym: cystadenolymphoma) represents one of the most frequent salivary gland tumors with a frequency equaling or even outnumbering that of pleomorphic adenomas in some series. Histologically, the tumor displays tall columnar oncocytic cells, arranged into two cell-thick layers lining variably cystic glands within an organoid lymphoid stroma. Tumors with exuberant squamous metaplasia in response to FNA-induced or other types of tissue injury/infarction have been referred to as “metaplastic WTs.” However, the same terminology was used for tumors with variable mucinous cell and solid or stratified epidermoid proliferations (occasionally mimicking mucoepidermoid carcinoma), although the “metaplasia concept” has never been proven for the latter. We herein investigated 22 WTs showing prominent mucoepidermoid-like or solid oncocytoma-like proliferations without prior FNA or histological evidence of infarction/ trauma using the TruSight Tumor 15 gene panel and KRAS pyrosequencing. As a control, we tested 11 conventional WTs. No statistically significant differences were observed between the two subcohorts regarding patient’s age and tumor size. Six of 22 (27%) proliferating/ metaplastic WTs revealed oncogenic KRAS mutations clustering at codon 12 (exon 2), while all conventional tumors lacked these mutations. Our findings are in line with a neoplastic nature of the epidermoid/ mucoepidermoid proliferations in non-injured “metaplastic” Warthin tumors. We propose the descriptive term “de novo proliferating Warthin tumor” for this variant to distinguish it from infarcted/inflamed genuine metaplastic Warthin tumor.
Schmerztherapie in der deutschen spezialisierten ambulanten Palliativversorgung
Authors: Volberg Christian , Corzilius Julien , Maul Julian , Morin Astrid , Gschnell Martin 
Published: February 2023

Zusammenfassung
Hintergrund
Mithilfe der spezialisierten ambulanten Palliativversorgung (SAPV) können in Deutschland schwersterkrankte und sterbende Patienten im häuslichen Umfeld bis zum Lebensende adäquat versorgt werden. Es gibt für die Schmerztherapie jedoch keine einheitlichen Standards oder Vorgaben, wie diese am besten durchgeführt werden sollte.

Ziel der Arbeit
Diese Arbeit dient der Grundlagenforschung im Bereich der Versorgungsforschung. Es soll dargestellt werden, welche Möglichkeiten (Einsatz verschiedener Berufsgruppen, Medikamente, alternativmedizinische Behandlungen etc.) die einzelnen SAPV-Teams für die Schmerztherapie nutzen, um daraus ableiten zu können, welche Strukturen als besonders effektiv angesehen werden können.

Material und Methodik
Diese Querschnittsstudie wurde im Mai 2021 durchgeführt. Alle auf der Homepage der Deutschen Gesellschaft für Palliativmedizin (DGP) gelisteten SAPV-Teams (n = 307) wurden postalisch angeschrieben und um Teilnahme gebeten. Insgesamt antworteten 175 (57 %) Teams auf die Anfrage und konnten in die Auswertung eingeschlossen werden. Es wurde eine rein deskriptive Datenauswertung durchgeführt.

Ergebnisse
Die Schmerztherapie in der deutschen ambulanten Versorgung palliativer Patienten basiert auf unterschiedlichen Bausteinen. Alle gängigen Schmerzmedikamente werden eingesetzt, vor allem aber Metamizol (99,4 %) als Nichtopioidanalgetikum, Morphin (98,3 %) aus der Reihe der Opiate und Pregabalin (96,6 %) als Koanalgetikum. Bei nichtbeherrschbaren Schmerzen führen 22,5 % der SAPV-Teams regelhaft eine palliative Sedierung zur Symptomlinderung durch.

Diskussion
Diese Erhebung gibt als erste dieser Art einen generellen Überblick über die eingesetzten Verfahren zur Schmerztherapie in der ambulanten palliativmedizinischen Versorgung. Im Vergleich mit internationalen Studien stellt sich die Frage, ob eventuell einheitliche Therapieschemata und eine Reduktion der zur Verfügung stehenden Medikamente in den einzelnen SAPV-Teams zu einer Verbesserung der Patientenversorgung führen könnten.
Comparable efficacy and safety of COVID-19 vaccines for patients receiving tegafur–uracil as postoperative adjuvant chemotherapy
Authors: Nishikubo Megumi , Tanaka Yugo , Mitsui Suguru , Doi Takefumi , Hokka Daisuke , Hojo Wataru , Sakai Hironori , Funakoshi Yohei , Yakushijin Kimikazu , Ohji Goh , Minami Hironobu , Maniwa Yoshimasa 
Published: February 2023

Abstract
Purpose
Many effective vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been developed, but a weaker response in individuals undergoing anticancer treatment has been reported. This study evaluates the immunogenic status and safety of SARS-CoV-2 vaccines for patients with non-small-cell lung cancer (NSCLC), receiving tegafur–uracil (UFT) as postoperative adjuvant chemotherapy.

Methods
The subjects of this prospective study were 40 patients who underwent surgery for NSCLC and received SARS-CoV-2 vaccines postoperatively. We compared the antibody titers of SARS-CoV-2 vaccines and the adverse events between patients who received adjuvant UFT and patients who did not.

Results
The mean anti-S1 IgG titers were not significantly different between the UFT and without-UFT groups (mean optimal density, 0.194 vs. 0.205; P = 0.76). Multivariate analysis identified the period after the second vaccination as an independent predictor of anti-S1 IgG titer (P = 0.049), but not the UFT status (with or without-UFT treatment; P = 0.47). The prevalence of adverse events did not differ significantly between the groups, and no severe adverse events occurred.

Conclusions
The efficacy and safety of the SARS-CoV-2 vaccines for NSCLC patients who received postoperative adjuvant UFT chemotherapy were comparable to those for NSCLC patients who did not receive postoperative adjuvant UFT chemotherapy.

Clinical trial registration
This study was registered with the University Hospital Medical Information Network (UMIN) in Japan (UMIN000047380).
Trustworthy agent-based simulation: the case for domain-specific modelling languages
Authors: Zschaler Steffen , Polack Fiona A. C. 
Published: February 2023

AbstractSimulation is a key tool for researching complex system behaviour. Agent-based simulation has been applied across domains, such as biology, health, economics and urban sciences. However, engineering robust, efficient, maintainable, and reliable agent-based simulations is challenging. We present a vision for engineering agent simulations comprising a family of domain-specific modelling languages (DSMLs) that integrates core software engineering, validation and simulation experimentation. We relate the vision to examples of principled simulation, to show how the DSMLs would improve robustness, efficiency, and maintainability of simulations. Focusing on how to demonstrate the fitness for purpose of a simulator, the envisaged approach supports bi-directional transparency and traceability between the original domain understanding to the implementation, interpretation of results and evaluation of hypotheses.
Cross-language font style transfer
Authors: Li Chenhao , Taniguchi Yuta , Lu Min , Konomi Shin’ichi , Nagahara Hajime 
Published: February 2023

AbstractIn this paper, we propose a cross-language font style transfer system that can synthesize a new font by observing only a few samples from another language. Automatic font synthesis is a challenging task and has attracted much research interest. Most previous works addressed this problem by transferring the style of the given subset to the content of unseen ones. Nevertheless, they only focused on the font style transfer in the same language. In many cases, we need to learn font style from one language and then apply it to other languages. Existing methods make this difficult to accomplish because of the abstraction of style and language differences. To address this problem, we specifically designed the network into a multi-level attention form to capture both local and global features of the font style. To validate the generative ability of our model, we constructed an experimental font dataset of 847 fonts, each containing English and Chinese characters with the same style. Results show that our model generates 80.3% of users’ preferred images compared with state-of-the-art models.
Conservation at the edge: connectivity and opportunities from non-protected coral reefs close to a National Park in the Colombian Caribbean
Authors: Rodríguez Laura , Acosta Alberto , González-Zapata Fanny L. , Gómez-Corrales Matías , Marrugo Milena , Alvarado-Ch. Elvira M. , Dueñas Luisa F. , Andrade Julio , Gutierrez-Cala Lina , Sánchez Juan A. 
Published: February 2023

AbstractConfronting a sustained coral reef conservation crisis, we need new opportunities to rethink how to protect areas successfully and efficiently in the face of a changing world. We studied the benthic community, including foraminifera, fish community, and genetic connectivity (SSRs and SNPs) of main reef-building corals, Orbicella faveolata and Agaricia undata, along a Non-Protected Area (NPA) reef tract in Barú peninsula, including some isolated banks, near Cartagena and the National Natural Park Corales del Rosario y San Bernando (NNP CRySB), Colombia. The fringing reef track is homogeneous in benthic components, including algae, sponges, and foraminifera between all the studied sites, while corals exhibited differences between sites and depth ranges. Many reef sites sustain between 42.8 and 53% coral cover, which are among the highest recorded in this region, even higher than the nearby NNP. A total of 82 fish species were found, and the Foram Index-FI varies between 2 and 2.5, showing environmental conditions marginal for reef growth. The Barú NPA reef system can be considered spatial refugia under climate change and Anthropocene conditions, including resilient reefs at the mouth of Cartagena Bay (Magdalena River), a place of increased stressing factors. The admixture between NPA and NNP populations, the high coral cover in the NPA, the fish density and composition, the uniqueness of the diapiric banks, and the disturbance resistance are major arguments to protect this reef tract. We suggest designing a co-management scheme to ensure species connectivity, avoid further degradation, and involve different stakeholders.
Isolation and evaluation of Bacillus subtilis RSS-1 as a potential biocontrol agent against Sclerotinia sclerotiorum on oilseed rape
Authors: Cao Shun , Jiang Bingxin , Yang Guogen , Pan Guangxue , Pan Yuemin , Chen Fangxin , Gao Zhimou , Dai Yuli 
Published: February 2023

Abstract
Sclerotinia stem rot caused by Sclerotinia sclerotiorum is one of the most important diseases of oilseed rape in the world. Because of the absence of resistant varieties and the disadvantages of chemical control, application of antifungal microbes has become an eco-friendly and effective measure to control this disease. In this study, Bacillus subtilis strain RSS-1, isolated from soil samples, was identified based on morphological, physiological and biochemical tests, and DNA gyrase subunit A (gyrA), gyrB, DNA-directed RNA polymerase subunit beta (rpoB) and rpoC gene sequence analysis. It significantly inhibited mycelial growth and sclerotial production of S. sclerotiorum in vitro. In greenhouse experiments, all three tested concentrations (106, 107, 108 cfu mL−1) of cell fermentation broth and culture filtrate significantly reduced the severity of sclerotinia stem rot on oilseed rape (P < 0.05). RSS-1 was more effective at reducing disease severity when applied 24 h before inoculation with S. sclerotiorum than at 24 h post inoculation, suggesting that RSS-1 should be applied as a prophylactic rather than a curative biological agent. Colonization tests indicated that the population density of RSS-1 on rapeseed leaves significantly decreased (P < 0.05) over 6 days. However, RSS-1 could stably colonize in rhizospheric soil of rapeseed over 30 days. Challenge inoculation tests showed that RSS-1 significantly inhibited the activities of polygalacturonase and cellulase and accumulation of oxalic acid during the S. sclerotiorum infection. These results suggest that RSS-1 was a potential biological agent for controlling sclerotinia stem rot caused by S. sclerotiorum on oilseed rape.
Diverging or converging to a green world? Impact of green growth measures on countries’ economic performance
Authors: Ferreira João J. , Lopes João M. , Gomes Sofia , Dias Claudia 
Published: February 2023

AbstractGreen growth has emerged in recent years to respond to environmental problems caused by climate change and the scarcity of resources. However, today’s green growth involves environmental, social and financial dimensions. In this context, many countries are currently seeking green growth for their economic development through the efficient use of their resources. This study aims to assess the impact of green growth performance on the economic development of countries. A quantitative approach was applied to a sample of 172 countries worldwide, and the formulated hypotheses were tested through multiple linear regressions estimated by the ordinary least squares method. The economic development of countries was measured by the Human Development Index (HDI) and measures the sustainability performance of countries by the Green Growth Index (GGI). The results of this study demonstrate that (i) the measures of green growth performance have a positive impact on the economic development of high-income, upper-middle-income, and lower-middle-income economies, (ii) in poorer economies, less is the contribution of green growth to economic development, mainly because they neglecting the social dimension despite the numerous existing projects in these economies for greater inclusion and (iii) green economic opportunities (green investment, green trade, green employment and green innovation) do not influence green economic development in all analysed economies. Consequently, suggestions were made for policymakers from different groups of countries to increase and accelerate their sustainable green growth. Literature on economic development and green growth is still scarce, especially at the empirical level, and few studies use the 2020 GGI data. In addition, this study also uses recent rankings of world economies to categorize the economic development of countries.
An Exploratory Study to Understand Nonprofit Organizations’ Crisis Leadership Competencies: A Portuguese Analysis on COVID-19
Authors: Esteves Salete , Santos Lara , Lopes Luisa 
Published: February 2023

AbstractThe purpose of this study is to investigate the factors that affect the Nonprofit Organization’s (NPO) competencies and leadership in a crisis situation, specifically in the Portuguese NPOs during COVID-19. Adopting an interdisciplinary perspective, this article integrates crisis management literature with leadership literature. Highlighting the leadership perspective of both intermediate employees (technical director) and top management (executive director), this research aims to advance knowledge on the main organizational leadership competencies that NPOs need to have to better cope with crises. One hundred and seventy-four (174) NPOs representatives voluntarily participated in the study which involved a survey questionnaire based on a five-point Likert scale for 23 items included in the questionnaire. Principal component analysis using varimax rotation was applied to reduce the number of variables. Reliability tests were performed to assess the items included in the questionnaire. Tests included test-retest reliability, Cronbach alpha, and split-half reliability coefficients. Results show that the most important factors that improve the capability of a NPO to cope with a crisis are: respond to all stakeholders through accountability, plan based on identification of vulnerabilities, and build a foundation of trust through communication. Additionally, it is possible to suggest that staff and top management perceive crisis and leadership competencies differently. It is possible to conclude, that these factors can be used as important lines of action to structure the sustainable development and planning of NPOs’ strategies of other similar crisis to come in the future. Findings, the implications of this work, and avenues for future NPOs crisis management and leadership research are addressed.
Facing Reciprocity: How Photos and Avatars Promote Interaction in Micro-communities
Authors: Teubner Timm , Camacho Sonia 
Published: February 2023

AbstractOnline platforms facilitate the formation of micro-communities on the Internet by enabling exchange between locally dispersed individuals. Since all interactions are mediated through the online platform, user representation plays a critical role for such communities. Grounded in Social Exchange Theory, we report results of a behavioral experiment on the role of user profile photos and avatars for the emergence of network structures over time. While overall network value increases slightly, the underlying structures of exchange shift systematically from many weak ties to fewer but significantly stronger reciprocal exchange relations. Interestingly, despite representing users in a highly abstracted way, avatars yield outcomes comparable to those when using actual photographs. We discuss theoretical and practical implications of how online platforms can leverage social cues such as profile photos and avatars to manage and support micro-communities.
Unpacking resilience in higher education: investigating twenty-first-century shifts in universities’ academic cores
Authors: Young Mitchell , Pinheiro Rómulo , Avramovic Aleksandar 
Published: February 2023

Abstract
The political, social, and institutional environments in which contemporary universities operate have changed rather dramatically over the past two decades in ways that threaten the resilience of the academic core, both in its ability to map knowledge comprehensively and also to maintain a balance between the branches of the humanities, social sciences, and natural sciences. This paper traces historical changes (2003–2019) in the academic core of two “flagship” research-intensive universities located in Northern Europe. The results show that some branches of the academic core are undergoing dynamic processes of program churn that make them resilient. Furthermore, the data show that this resilience is enabled in large part by bridging different branches of knowledge by establishing what we term interbranch programs. In addition to the abovementioned findings, the paper links ongoing discussions regarding change in HE systems and institutions to the literature on organizational resilience, and it advances insights for a possible future theory of how adaptation plays out in the academic core over time.
Do Children Matter to the Household Debt Burden?
Authors: Kowalski Ryszard , Strzelecka Agnieszka , Wałęga Agnieszka , Wałęga Grzegorz 
Published: February 2023

AbstractIn this paper, we assess the scale of indebtedness of households with children and investigate the impact of having children on the likelihood of falling into excessive debt. Using the unique dataset on indebted households in Poland, we employ two indicators to identify over-indebtedness: debt service-to-income ratio (DSTI) and subjective debt burden (SB). Applying two different debt measures allows encompassing both the economic and psychological dimensions of debt burden. In addition, we divide households into two groups: young (with a reference person aged under 35) and middle-aged and older adults (aged 35+). We find that the number of children increases the monthly debt repayments and reduces the likelihood of over-indebtedness, both according to DSTI and SB, for middle-aged and older adult households. There is no evidence for the influence of children on the over-indebtedness of young families. Our results suggest that for this age group of households, the other variables related to their economic situation and debt structures may explain the likelihood of over-indebtedness better than the presence of children.
Awareness of Infectious Disease Screening During Early Pregnancy and Knowledge About its Vertical Transmission in Japan: A Report from the Pregnant Women Health Initiative
Authors: Odagami Mizuha , Iwata Akiko , Kubota Kazumi , Kurasawa Kentaro , Okuda Mika , Aoki Shigeru , Hirabuki Tomoo , Tujie Tomoko , Saji Haruya , Hasegawa Tetsuya , Kobayashi Natsuko , Ueda Yutaka , Ishioka Shinichi , Enomoto Takayuki , Tsuji Makoto , Shigeta Hiroyuki , Koike Kumi , Tanaka Hiroaki , Tsukinaga Rie , Hasegawa Yoshimi , Numazaki Reiko , Ota Hajime , Kase Hiroaki , Ishikawa Hiroshi , Saito Yoshihiro , Yamawaki Takaharu , Miyagi Etsuko 
Published: February 2023

Abstract
Objectives
We aimed to clarify the accuracy of pregnant women’s knowledge and understanding regarding infectious disease screening in early pregnancy and clarify the roles that should be played by health care providers in promoting the health of pregnant women and their children.

Methods
A cross-sectional questionnaire survey was conducted in 25 hospitals across Japan from May 2018 to September 2019. We compared the agreement rates regarding screening results for hepatitis B virus (HBV), hepatitis C virus (HCV), syphilis, human T-cell leukemia virus-1 (HTLV-1), and cervical cytology in the medical records and understanding of their results by pregnant women. We then investigated whether participants had knowledge regarding the risk of mother-to child transmission in these diseases and factors associated with their knowledge.

Results
We enrolled 2,838 respondents in this study. The rates of agreement for HBV and cervical cancer screening related to human papillomavirus infection were “substantial,” those for syphilis was “moderate,” and those for HCV and HTLV-1 were “fair,” according to the Kappa coefficient. The rate of knowledge regarding mother-to-child transmission of syphilis was highest (37.0%); this rate for the other items was approximately 30%. Increased knowledge was associated with higher educational level and higher annual income.

Conclusions for Practice
Pregnant women in Japan had generally good levels of understanding regarding their results in early-pregnancy infectious disease screening. However, they had insufficient knowledge regarding mother-to-child transmission of these diseases. Health care providers should raise awareness in infectious disease prevention among pregnant women and the general public, providing appropriate measures and implementing effective perinatal checkups and follow-ups for infectious diseases.