bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tilt Angle Filter Effect on Noise Cancelation and Structural Edges Detection in Hydrocarbon Sources in a Gravitational Potential Field
Authors: Hosseini Seyed Aliakbar , Khah Nasser Keshavarz Faraj , Kianoush Pooria , Arjmand Yaser , Ebrahimabadi Arash , Jamshidi Emad 
Published: May 2023

Abstract
Noise cancelation is the process done to remove out-of-range anomalies and make better edge boundaries interpretation. One of the most challenging issues in describing gravitational maps is separating the anomalies related to shallow sources from the deep ones. Furthermore, Existing noise can make it arduous to separate shallow blurred boundaries. In this study in SE Iran, gravitational surveying was carried out in shallow areas from the west of Qeshm to the Hormuz islands in a regular network with a distance of one kilometer. The range of gravitational Bouguer was -297 to -330 mGal. Modeling and determining geometrical parameters revealed five negative anomalies from salt penetration. The residual gravity was computed by deducting gravitational effects related to deep sources from measured gravitational data. Correspondingly, estimating the boundary and edge of the subsurface masses will be better than local filters, and anomalies will be highlighted with more intensity. Furthermore, three major fault systems in the Zagros basin were determined as the primary origin of activity and expansion of Hormuz salt. Sensitivity analysis was employed utilizing analytical signals and maps of tilt angle filtering, which both revealed the same satisfying results of -297 to -330 mGal. In this article, the effect of the tilt angle local phase filter on a synthetic model was accomplished through numerical coding. As a result, Total Horizontal Derivative (THDR) provides location of salt intrusion in Qeshm area; whereas the best image of salt intrusion, in terms of feature edge illumination, presented by Analytical signal of residual gravity map.
Early warning value of urinary oxygen tension monitoring for paediatric intensive care unit sepsis-associated acute kidney injury: a retrospective study
Authors: Mao Haoyun , Xu Lili , Qian Wen , Ma Zhushengying , Wan Sibei , Zhu Xiaodong , Xu Yaya 
Published: May 2023

Abstract

Backgroud To explore whether monitoring of non-invasive urine oxygen tension (PuO2) for 3 consecutive days can reflect renal medulla microcirculation injury early and whether changes in PuO2 (△PuO2) have reliable early diagnostic value for sepsis-associated acute kidney injury (SA-AKI).
Methods Twenty-four patients who were hospitalised for more than 48 h in our hospital and were diagnosed with sepsis were retrospectively divided into non-SA-AKI group and SA-AKI group according to the occurrence of acute kidney injury (AKI). The general and oxygen metabolism data of the two groups were compared. The results of urine analysis (PuO2, PuCO2, and urinary lactic acid) for 3 consecutive days were compared with common clinical kidney injury indices, and a changing trend was observed.
Results In the PICU, a total of 24 patients with sepsis were included (14 males, 58.33%; mean age, 5 years), with 15 cases in the non-SA-AKI group and 9 cases in the SA-AKI group, with incidence of SA-AKI being 37.5%. PuO2 gradually decreased from D0 to D2 in the SA-AKI group; PuCO2 increased naturally. The variation trend of PuO2 was statistically significant in D1-D0, D2-D0, and D2-D1 (P<0.05), and the △PuO2 of D2-D0 (10.83±25.69 vs. -41.13±34.98, P=0.001). The early diagnostic value of PuO2 was significant (AUC=0.885, 95% CI: 0.704–1.000).
Conclusions Three consecutive days of PuO2 monitoring can reflect early renal medullary microcirculation injury, and △PuO2 has early diagnostic value for SA-AKI.
Self-sensing Intelligent Microrobots for Non-Invasive and Wireless Monitoring Systems
Authors: Zhao Jing , Li Zhongyi , Wang Kun , Hou Chaojian , Li Chunyang , Zhang Fanqing , Ren Wu , Dong Lixin 
Published: May 2023

Abstract
Microrobots present great potential and wide applications in in-situ treatment and attract tremendous attention due to their small size and flexible movement. However, functional modification for microrobots became more important for their interaction with the environment, except for precise motion control. Here, we design a novel artificial intelligence (AI) microrobot, which can respond to changes in the external environment without onboard energy supplying and transmit signals wirelessly in real time. The AI microrobot can cooperate with external electromagnetic imaging equipment and enhance the local radiofrequency (RF) magnetic field to achieve a large penetration sensing depth and a high spatial resolution. The working ranges are determined by the structure of the sensor circuit and the corresponding enhancement effect can be modulated by the conductivity and permittivity of the surrounding environment, reaching ~ 560 times at most. Under the control of an external magnetic field, the magnetic tail can actuate the microrobotic agent to move accurately, with great potential to realize in-situ monitoring in different places in a human body in an almost noninvasive fashion, especially around potential diseases, which is of great significance for early disease discovery and accurate diagnosis. In addition, the compatible fabrication process provides an approach to swarms of functional microrobots. The findings highlight the feasibility of the self-sensing AI microrobot for the development of in-situ diagnosis or even treatment according to the sensing signals.
Development of a predictive model for one-year postoperative recovery in patients with lumbar disc herniation based on deep learning and machine learning
Authors: Chen Yan , Lin Fabin , Wang Kaifeng , Chen Feng , Wang Ruxian , Lai Minyun , Chen Chunmei , Wang Rui 
Published: May 2023

AbstractBackgroundThe aim of this study is to develop a predictive model utilizing deep learning and machine learning techniques that will inform clinical decision-making by predicting the one-year postoperative recovery of patients with lumbar disc herniation.MethodsThe clinical data of 273 inpatients who underwent tubular microdiscectomy (TMD) between January 2018 and January 2021 were retrospectively analyzed as variables. The dataset was randomly divided into a training set (n = 191) and a test set (n = 82) using a ten-fold cross-validation technique. Various deep learning and machine learning algorithms including decision trees, random forests, extreme gradient boosting, support vector machines, parsimonious Bayes, K-nearest neighbors, L2-regularized logistic regression, unregularized logistic regression, and neural networks were employed to develop predictive models for the recovery of patients with lumbar disc herniation one year after surgery. The cure rate score of lumbar JOA score one year after TMD was used as an outcome indicator, and the area under the receiver operating characteristic curve (AUC) was selected as the main measure of learner superiority.ResultsThe correlation matrix heat map indicated that there was no need to use data reduction techniques prior to model development. The predictive model employing both machine learning and deep learning algorithms was constructed using 43 collected variables. Among the nine algorithms utilized, the L2-regularized logistic regression algorithm demonstrated the highest value of the area under the receiver operating characteristic curve (AUC).ConclusionsOur study findings demonstrate that the L2-regularized logistic regression algorithm provides superior predictive performance for the recovery of patients with lumbar disc herniation one year after surgery.
Preclinical to Clinical Profile of Curcuma longa as Antidiabetic Therapeutics
Authors: Kaushik Shikha , Masand Neeraj , Iyer Malliga R. , Patil Vaishali M. 
Published: May 2023

Abstract:Natural product substances have historically served as the most significant source of new leads for pharmaceutical development. Presently, drug discovery and development have adopted ra-tional approaches to explore herbal resources for treating lifestyle-related diseases such as diabetes. For the treatment of diabetes, Curcumin longa has been extensively studied for evaluation of its an-tidiabetic potential using various in vivo and in vitro models. Literature resources such as PubMed and Google Scholar have been extensively searched to collect documented studies. Various parts of the plant and extracts have proven antidiabetic effects, namely, anti-hyperglycemic, antioxidant, and anti-inflammatory action, through different mechanisms. It is reported that the plant extract or its phytoconstituents regulate glucose and lipid metabolism. The reported study concluded the diversi-fied antidiabetic role of C. longa and its phytoconstituents and, thus, its potential use as an antidia-betic agent.
Assisted Reproductive Technologies Helping Infertile Couples or Using
Minor Girls in Poverty; Boon or Bane?
Authors: Kulanthaivel Shanmugaraj , Kaliberdenko Vitalii B. , Balasundaram Keerthanaa 
Published: May 2023

Abstract:
According to WHO data, one in every four couples in developing countries is affected by
infertility, and the prevalence remains high year by year. Infertility is considered to be a globally concerned
health issue, which affects millions of people of reproductive age worldwide. Nowadays in our
modern and developing field of medicine, we have different solutions and treatments for almost each
and every disease. Treatment for infertility varies based on the cause, from simple psychological therapy
to some complicated procedures. All these procedures are regulated by World Health Organization
and their own country’s legislation. Each country has uniqueness in their legislation, but almost
all countries mainly focus on ethics, medical outcomes and health of both donor and recipients. However,
in some parts of the world, laws are sometimes over-ruled and not abided properly. One of such
recent incident took part in southern part of India (4 private hospitals in Tamilnadu, and 2 more hospitals
in Andhra Pradesh and Kerala), which made a shocking news for people all over the country. The
minor girl aged 16 years was exploited as egg (oocyte) donor. In the modern world, we are focusing
and researching more and more on female related health problems, but such incidents worry us. We
have a responsibility to prevent from such dreadful incidents in future, since respective governments
and courts proceed the case for veracity and justice. As doctors or medical professionals, we have to
follow our own medical and professional ethics. And as a citizen, all people including doctors and patients
must obey our countries own rules and regulations accordingly. Further we request government
authorities to make procedures and laws to be more strict and highly punishable when violated.
Successful Management of Uterocutaneous Fistula After Cesarean Delivery:
A Case Report
Authors: Yazdi Zahra , Mirzaie Monireh , Yadollahi Parvin , Khalajinia Zohre 
Published: May 2023

Background:
We have, herein, presented a case of an uterocutaneous fistula after cesarian
delivery.

Case Presentation:
A 24-years old female, gravida 3 para 3 with 2 living children, who underwent an
emergency cesarean section about one month before the term due to preterm labor at Hamedan, was
diagnosed with uterocutaneous fistula. Her medical history included 2 previous term cesarean section
deliveries. She reported having fever and chills three weeks after the cesarian delivery. She also developed
nausea, vomiting, and epigastric pain. Abdominal examination revealed a 30×40mm, firm,
and tender mass on the right side of the cesarian section suture without any discharge. She was admitted
with metritis as a primary diagnosis at N.H.F hospital. The performed transvaginal ultrasonography
reported a hetero-echo mass with a diameter of 38×30×37mm with several echogenic foci and
cystic components in the right ovary. After that, an abdominopelvic CT scan was done, and a
30×40mm mass in the right ovary with non-homogeneous due to collection and abnormal density with
local hematoma at the site of the previous cesarian section was reported. Due to suspicion of lesion,
the surgery was performed with the diagnosis of fascia opening and right Tubo-ovarian abscess and
the infectious discharge of the right ovary. Right salpingo-oophorectomy surgery was performed. She
was admitted again with the complaint of infectious discharge from the right side of the suture and erythema
for one month. She also developed generalized abdominal pain. The patient was, thus, diagnosed
with a uterocutaneous fistula and was admitted to the center. She became a trans-abdominal
hysterectomy candidate and underwent surgery.

Conclusion:
One of the important risk factors for the fistula to be formed is an abscess. A few cases
have been reported of post-cesarean uterocutaneous fistula in the literature. Surgical treatment associated with medical therapy can be effective in women with multiple cesarian sections. Any infected dehiscence must be radically operated.
Early markers of Sepsis Cardiomyopathy in Murine Models by Echocardiography
Authors: Nirala Sanjeev , Rui Tan Xue 
Published: May 2023

Background:
Strain echocardiography (SE) is a procedure for analyzing myocardial dysfunction that is known to be less dependent on preload and afterload of heart function. Unlike dimension-based parameters, like ejection fraction (EF) and fractional shortening (FS), SE measures cardiac function by tracking cardiac tissue deformation and anomalies throughout the cardiac cycle. Although SE is proven to locate myocardial ailments in various heart diseases, few studies exist regarding using SE relevant to sepsis pathophysiology.

Objective:
The study aimed to calculate the myocardial strain and strain rates, like longitudianl strain (LS), global radial strain (GRS), and global longitudinal strain (GLS), and to show these to be reduced earlier in cecal ligation and puncture (CLP) and lipopolysaccharide (LPS)-induced sepsis in coordination with an elevation of pro-inflammatory cytokines

Methodology:
Wild-type mice C57BL/6J (WT) were taken in this study and classified as CLP, LPS, and control groups. CLP surgery and LPS injection were given to induce sepsis. Endotoxemic septic shock was induced by intraperitoneal (IP) injection of LPS Escherichia coli.Echocardiography short axis views (SAX), longitudinal strain (LS), global circumferential strain (GCS), and global radial strain (GRS) were measured from the anterior and posterior positions of the septal and lateral walls of the heart. Real-time polymerase chain reaction (RT-PCR) was performed to evaluate post-CLP and LPS to analyze cardiac pro-inflammatory cytokines expressions. Inter- and intra-observer variables were tested by Bland-Altman analyses (BA). All data analysis was performed by GraphPad Prism 6 software. p<0.05 was taken as statistically significant.

Result:
After 48 hours following CLP and LPS-induced sepsis, a significant declination in both longitudinal strain and strain rate (LS and LSR) was identified in the CLP and LPS groups compared to the control group. Strain depression in sepsis was linked with the up-regulation of pro-inflammatory cytokines in RT-PCR analysis.

Conclusion:
In the present study, we found myocardial strain and strain rate parameters, like LS, GRS, and GLS, to be reduced after CLP and LPS-induced sepsis in coordination with the elevation of pro-inflammatory cytokines.
Human Umbilical Cord Mesenchymal Stem Cells Alleviate Rat Knee Osteoarthritis
via Activating Wnt/ β-catenin Signaling Pathway
Authors: Zhou Yue , Zhao Yingjie , Wu Yujiao , Chen Jingyu , Wu Huaxun , Wei Wei , Yan Shangxue 
Published: May 2023

Background:
Osteoarthritis (OA) is a chronic disease characterized by joint cartilage degeneration,
destruction, and osteogenic hyperplasia. Human umbilical cord mesenchymal stem cells (hUCMSCs)
have attracted increasing research interest due to their high clonogenic, proliferative, and migratory
potential, as well as their improved secretion of relevant chondrogenic factors. This study evaluated the
therapeutic potential and underlying mechanism of hUC-MSCs in alleviating pathological symptoms of
OA.

Methods:
For the in vivo study, OA rats were established by the Hulth method to observe the therapeutic
effect of intra-articular injection of hUC-MSCs. X-ray tests, gross observations, and histological and immunohistochemical
assessments were conducted in rats. Levels of interleukin-1 beta (IL-1β), IL-6, matrix
metalloproteinase-13 (MMP-13), and tissue inhibitor matrix metalloproteinase-1 in rats’ synovial fluid
were measured using enzyme-linked immunosorbent assay kits. For the in vitro study, hUC-MSCs and
chondrocytes were cultured to explore the effect and underlying mechanisms of hUC-MSCs on OA.
Apoptosis, proliferation, and glycosaminoglycan (GAG) were measured in the chondrocytes. The relative
expression of aggrecan, COL-2, and SOX-9 mRNA was quantified by real-time polymerase chain reaction.
Expressions of Wnt/β-catenin signaling molecules were measured by Western blot.

Results:
We found that intra-articular injection of hUC-MSCs reduced the combined score, increased the
expression of collagen II, and decreased the expression of MMP-13, IL-1β, and IL-6 in rat knee joints.
Additionally, hUC-MSCs increased the content of GAGs, inhibited chondrocyte apoptosis, and promoted
chondrocyte proliferation. The expression of aggrecan, COL-2, and SOX-9 mRNA in chondrocytes was
promoted by hUC-MSCs via activation of the Wnt/β-catenin signaling pathway.

Conclusion:
Overall, this study demonstrated that hUC-MSCs induce the secretion of some cytokines via
the paracrine function to activate the Wnt/β-catenin signaling pathway to reduce the pathological condition
of OA and maintain the proper expression of cytokines and extracellular matrix proteins.
Dyslipidemia and Cardiovascular Prevention in the Elderly: A Balance
between Benefits and Risks of Statin Treatment in a Specific Population
Authors: Fiore Vincenzo , Barucca Alessandra , Barraco Sonia , Triggiani Domenico , Tragni Daniele , Piazzolla Giuseppina , Triggiani Vincenzo , Carbotta Giovanni , Lisco Giuseppe 
Published: May 2023

Introduction:
Atherosclerotic Cardiovascular Diseases (CVD) are among the most relevant causes of morbidity and mortality worldwide, especially in aged people. Statins are one of the leading pharmacological interventions against atherosclerosis and are widely used to reduce the risk of occur-ring coronary artery diseases and related outcomes in both primary and secondary prevention. The management of chronic diseases is improved considerably over time, leading to an increase in life ex-pectancy despite heavier comorbidity-related burdens in the elderly.

Aims:
The paper focused on the role of statins in the management of atherosclerosis and related burdens in elderly patients.

Results:
Statins are essential in reducing the risk of CVD in secondary and primary prevention, partic-ularly in high-risk individuals. Guidelines encourage using specific algorithms with age-specific cut-offs to assess individual cardiovascular risk irrespective of baseline age, as the expansion of life expec-tancy produces favorable effects of statin treatment in those over 70.

Discussion:
Besides the estimation of baseline CV risk, a specific age-related assessment is also nec-essary before prescribing statin treatment in aged people focusing on frailty, potential pharmacological interactions due to polypharmacotherapy, cognitive impairment, and background chronic comorbidi-ties, such as diabetes mellitus. Before starting statin therapy, an accurate choice of type and dose of statins is needed as potential adverse events are more prevalent with high-dose than low-to-moderate-dose regimens and with lipophile than hydrophile statins (e.g., potential implication on intra-cerebral cholesterol metabolism).

Conclusion:
Despite possible adverse events, elderly patients should receive statins, when appropriate, to avoid the first occurrence of recurrent cardiovascular events and related burdens.
Evaluation of Wound Healing Activity of Statin Impregnated Collagen Scaffold
in Wistar Albino Rats
Authors: Murthy Talasila Gopala Krishna , Chowdary Bodepudi Sudheer 
Published: May 2023

Background:
Wound healing is a dynamic process that is affected by various processes. Medications involved in wound healing can interfere with clot formation, inflammation reduction, and cell proliferation. Collagen is the natural existing compound that has the ability to enhance tissue regeneration. Various drugs used for healing have cons like inhibiting DNA, RNA, or protein synthesis, resulting in decreased fibroplasias and neovascularisation of wounds. Objective: The objective of this work is the formulation of the collagen scaffold impregnated with the Atorvastain using cow urine as solvent.

Methods:
The methodology involves the isolation of the collagen from the bones of the animals by using acetic acid. The obtained collagen was subjected to homogenization and sonification to get a fine powder. To this solvent, Atorvastatin and glycerine were added then it was dried at 60oC for 24 hrs to get the impregnated scaffold. The formulated scaffold was evaluated for wound healing activity by using the excision wound model.

Results:
The result shows that the scaffolds are good in nature and meet all the standards of the standard scaffold. The wound healing activity is assessed by using the excision wound healing model in rats. The results show the significant value of 99 % wound healing activity from the statin-impregnated scaffold. The biological parameters like total collagen, hexosamine, and uronic acid were evaluated and these observations indicated higher values of 4.024 ± 0.069, 304 ± 4.11, and 75.83 ± 1.93 compared with the plain scaffold.

Conclusion:
The optimised formulation exhibited good mechanical strength with better wound healing activity. The percent wound healing activity and antimicrobial activity observed from the collagen scaffold was found to be more significant compared with the scaffolds not containing statins.
Fractional Order Controller For Power Control in AC Islanded PV
Microgrid using Electric Vehicles
Authors: Rafia Anisha Asmy Nazir , Jayaprakash Ramprabhakar 
Published: May 2023

Background:
Microgrids conquer a significant role in the evolution of distributed and
modern grids from the traditional electricity system. However, microgrids with renewable energy
sources connected to them often incur grid instability issues, due to the intermittent nature of these
sources.

Objective:
This work aims to study Microgrids with Electric vehicles as a backup energy source
and maintain the system’s frequency that can overcome this issue.

Methods:
This paper uses an autonomous control algorithm in an islanded ac microgrid to regulate
the active power depending on the irradiation and load scenarios, thereby maintaining the system
frequency and stability. The controller also keeps track of the battery's charge level, keeping it
from overcharging or over-discharging conditions. The PI (Proportional Integral) and Fractional
Order Proportional Integral (FOPI) controllers were compared, with the best controller utilized for
system simulations.

Results:
Simulations are presented with MATLAB/Simulink for an Islanded Photo Voltaic AC microgrid
system with the electric vehicle's battery connected to it as a source of backup energy. The
system's effect is exhibited under varied irradiations and load levels, and the findings demonstrate
the control algorithm's adaptability.

Conclusion:
This work attempts to discover the capability of the control technique to maintaining
the stability of an AC islanded microgrid system under diverse irradiation and load situations, thereby
maintaining the system's frequency and the State of Charge (SoC) of the battery of an electric vehicle
under specified levels.