bluuebunny/crossref_metadata_2025_split huggingface dataset:
Selecting sustainable approach for remediation of PFOA contaminated soils: AHP decision-making
Authors: Soltanian Mehdi , Salmak Saba , Baghdadi Majid , gitipour Saeid , Ramandi Hamed Lamei 
Published: June 2023

Abstract
Perfluorooctanoic acid (PFOA), which is an emerging persistent organic and one of the most commonly used PFAS, has a wide range of applications in industrial and production processes, and humans can regularly be exposed to it, so remediation of PFOA-contaminated soil is of great importance. This research presents the importance of PFOA soil pollution, soil remediation related technologies, their mechanisms and the order of remediation priority for three different hypothetical scenarios. Our comprehensive literature review shows that while some remediation methods have shown positive results, some, such as ultrasound, are ineffective in terrestrial ecosystems. Despite the fact that generally, the selection of a practical and compelling soil remediation technique depends on site assessments, our investigation and analysis by implementing an analytical hierarchy process and considering remediation time, environmental impacts, ecological impact, soil disturbance, post management, etc. as criteria, leads to the solidification/stabilization, oxidation, electrokinetic, phytoremediation and bioremediation as the most feasible and promising approaches for remediation of PFOA contaminated sites in our three suggested scenarios, but with different preferences. On the other hand, negative aspects of the electron beam, pulsed corona, and ball milling have placed them at the bottom of our selection list for field scale remediation.
Acetylcholine Hydrolytic Activity of Fibrillated β-Amyloid (1-40) Peptide
Authors: Sanchis Ivan , Spinelli Roque , Siano Alvaro 
Published: June 2023

Abstract
Alzheimer's disease is characterized by the presence of senile plaques composed of β-amyloid peptide (Aβ) aggregates with toxic effects that are still not fully understood. Recently, it was discovered that Aβ(1-42) fibrils possess catalytic activity on acetylcholine hydrolysis. Catalytic amyloids are an emerging and exciting field of research. In this study, we examined the catalytic activity of the fibrils formed by Aβ(1-40), the most abundant Aβ variant, on acetylcholine hydrolysis. Our findings reveal that Aβ(1-40) fibrils exhibit moderate catalytic activity, indicating that natural peptide aggregates could serve as biocatalysts and provide new insights into the potential role of Aβ in neurological disorders.
Comprehensive bioinformatics analysis identifies specific female genetics for HCM with a higher cardiovascular risk
Authors: Kuang Hongyu , Liu Guangliang , Chen Yunlin , Long Yuxiang , Yin Yuehui 
Published: June 2023

Abstract
Background
The study was conducted to identify specific gene expressions and mostly associated mechanisms of sex differences in hypertrophic cardiomyopathy (HCM).
Methods and results The differential expressed genes (DEGs) and biological functions were analyzed. Furthermore, LASSO model, combined with SVM-RFE feature was applied for core genes. GO terms and gene set enrichment analysis (GSEA) were conducted. Core genes and related mechanisms were verified in male to tell the sex differences in genetics. There revealed seven core genes, i.e., ZFP36, CEBPD, S100A9, CDC42EP4, RASD1, S1PR3,and MYH6, with a significant decrease in HCM females. GSEA indicated there existed signaling pathways including fatty acid β-oxidation, tricarboxylic acid cycle enzyme complex, autophagy, and ribosome pathways involved in low expressions of these genes in female-specific HCM. Also, core gene expressions were verified in male-specific HCM, indicating more reduction of RASD1 and MYH6 in HCM females than males. As to autophagy-related signatures, expression levels of NAMPT decreased significantly in HCM women, with sex differences, meanwhile there presented a significantly positive correlation between NAMPT with RASD1 (R=0.557, p<0.001) orMYH6(R=0.516, p<0.001).
Conclusions
The comprehensive bioinformatic analyses indicated that low RASD1/MYH6/NAMPT expressions in cardiac tissues of females were closely related to HCM with a higher risk of cardiovascular events.
Are the Food Additives, Safe or Harmful? - A Review
Authors: Praveen Kumar  , Anita  , Neha Joshi  
Published: June 2023

In the previous century, it was common to add embalming fluid to milk to stop curdling. Once Dr. Wiley of FDA said he found was that eating borax "will create disturbances of appetite, digestion and health" 3.0f. embalming fluid, he said: "The addition of formaldehyde to food tends to derange metabolism." The FDA's Website provides a list of approved additives, which companies can legally include in food products. The length of this list is enormous - there are over a thousand different additives. Unfortunately; the list does not include a description of the possible side effects associated with these additives.[1]
Asrugdhara - A treatment approach through traditional Rasa Chikitsa and Ekamoolika Prayoga
Authors: Meenu Swaminath  , R.S Hiremath  
Published: June 2023

Introduction: To make the Ayurvedic physician more aware of menorrhagia and how they can serve a role in their patient’s care and education since women make up 60% of the population seeking ayurvedic natural care. In Ayurvedic classics, Menorrhagia is termed as Asrugdhara, means excessive discharge of blood per vaginum. Backache, pain in lower abdomen and weakness are also present in this disease. Materials & Method: A review of the ancient literature on menorrhagia was conducted. Items that were retrieved were synthesized and interpreted in order to give the best information to practise with easy way. Discussion: Most of the information available relative to menorrhagia is medically oriented. In this article included the role of Rasa preparations and easily available Ekamoolika Prayoga that can be practised in house hold level. Conclusion: Along with the proper knowledge of the disease and diagnosis, the ayurvedic treatment helps to cure the Asrugdhara in all age group of women. The patients have to be made aware the importance of following various regimen and easy traditional Ekamulika Prayogas to get the maximum result.
Role of Ahara in prevention of Life Style Disorders w.s.r. to Ashtavidha Ahara Visheshayatana
Authors: Sen Anil Kumar , Lajwanti Keswani  , Rajesh Kumar Malviya  , Salil Kumar Jain  , Parvati Kharadi  , Poonam Nagle  
Published: June 2023

Ayurveda is the foremost life science and describes ways to prevent lifestyle disorders. Ayurveda is the world's ancient health care system. Lifestyle disorders are due to Poor life-style which includes; poor diet, poor eating habits, lack of exercise, Smoking, excess alcohol, poor sleep, stress due to heavy workload and increased consumption of unhealthy food. Ahara Dravyas can be considered under the category Dravyabhuta Aushadhi. So, the dietetic rules can be considered as Upaya or Adravyabhuta Aushadhi for Vikaraprasamana. The eight factors of diet responsible for health and diseases are described as “Ahara Vidhi Vishesha Ayatanani”. Ahara is considered as Mahabhaishajya (the superior medicine). Various life style disorders and numerous diseases occur due to faulty dietary habits which may be prevented by proper Ahara and eating habits. Ayurveda insists that Ahara should be chosen in accordance to the Prakriti or constitution of individual. The diet is regarded as Brahman as it holds such supreme importance. “Annam Brahmeti Vyajaanat”. In general terms food includes all the edible substances. The original source of living beings and their strength, complexion and Ojas is diet which consists of Six Rasas and those again depend on substances.
The Overall Anxiety Severity and Impairment Scale as an Outcome Measure in Internet-Delivered Cognitive Behavioral Therapy for Anxiety Disorders: Observational Study
Authors: Karpov Boris , Lipsanen Jari Olavi , Ritola Ville , Rosenström Tom , Saarni Suoma , Pihlaja Satu , Stenberg Jan-Henry , Laizane Paula , Joffe Grigori 
Published: June 2023

Background
Internet-delivered cognitive behavioral therapy (iCBT) is effective in the treatment of anxiety disorders. iCBT clinical trials use relatively long and time-consuming disorder-specific rather than transdiagnostic anxiety measurements. Overall Anxiety Severity and Impairment Scale (OASIS) is a brief self-report scale that could offer a universal, easy-to-use anxiety measurement option in disorder-specific and transdiagnostic iCBT programs.

Objective
We aimed to investigate relationships between OASIS and disorder-specific instruments in iCBT. We expected these relationships to be positive.

Methods
We investigated patients in original nationwide iCBT programs for generalized anxiety disorder (GAD), obsessive-compulsive disorder, panic disorder, and social anxiety disorder, which were administered by Helsinki University Hospital, Finland. In each program, anxiety symptoms were measured using both disorder-specific scales (the 7-item Generalized Anxiety Disorder scale, Penn State Worry Questionnaire, revised Obsessive-Compulsive Inventory, Panic Disorder Severity Scale, and Social Phobia Inventory) and by OASIS. A general linear model for repeated measures (mixed models) and interaction analysis were used for investigating the changes and relationships in the mean scores of OASIS and disorder-specific scales from the first session to the last one.

Results
The main effect of linear mixed models indicated a distinct positive association between OASIS and disorder-specific scale scores. Interaction analysis demonstrated relatively stable associations between OASIS and the revised Obsessive-Compulsive Inventory (F822.9=0.09; 95% CI 0.090-0.277; P=.32), and OASIS and the Panic Disorder Severity Scale (F596.6=–0.02; 95% CI –0.108 to –0.065; P=.63) from first the session to the last one, while the 7-item Generalized Anxiety Disorder scale (F4345.8=–0.06; 95% CI –0.109 to –0.017; P=.007), Penn State Worry Questionnaire (F4270.8=–0.52; 95% CI –0.620 to –0.437; P<.001), and Social Phobia Inventory (F862.1=–0.39; 95% CI –0.596 to –0.187; P<.001) interrelated with OASIS more strongly at the last session than at the first one.

Conclusions
OASIS demonstrates clear and relatively stable associations with disorder-specific symptom measures. Thus, OASIS might serve as an outcome measurement instrument for disorder-specific and plausibly transdiagnostic iCBT programs for anxiety disorders in regular clinical practice.
Feasibility of a Career Development Intervention for Veterans in Vocational Rehabilitation: Protocol for a Pilot Randomized Controlled Trial
Authors: Stevenson Brian , Teravainen Taina , Kathawalla Ummul Kiram , Singer Margo , Wilkins Sarah , Mueller Lisa , Kelly Megan , Ellison Marsha , Shirk Steven D , Bakken Shana , Blustein David 
Published: June 2023

Background
Veterans with psychiatric disorders want additional career development services to support their recovery and pursuit of meaningful employment. However, no career counseling programs have been designed for this specific population. We developed the Purposeful Pathways intervention to fill this need.

Objective
This study protocol aims to (1) evaluate the feasibility and acceptability of the Purposeful Pathways intervention for veterans living with psychiatric disorders and (2) explore preliminary clinical outcome data.

Methods
A total of 50 veterans who are participating in transitional work vocational rehabilitation services at a Veterans Affairs hospital will be randomized to either treatment as usual or the augmented treatment condition (treatment as usual plus Purposeful Pathways). Feasibility will be assessed via recruitment rates, clinician fidelity to treatment, retention rates, and acceptability of randomization procedures. Acceptability will be assessed via client satisfaction at treatment termination using quantitative and qualitative data collection. Preliminary clinical and vocational outcomes will be assessed at baseline, 6 weeks, 12 weeks (treatment termination), and a 3-month follow-up via quantitative measures assessing vocational functioning, vocational process, and mental and physical functioning.

Results
This pilot randomized controlled trial is beginning recruitment in June 2023 and is expected to continue through November 2025. Data collection is expected to be completed by February 2026, with full data analysis completed by March 2026.

Conclusions
Findings from this study will provide information on the feasibility and acceptability of the Purposeful Pathways intervention, as well as secondary outcomes related to vocational functioning, vocational process, and mental and physical functioning.

Trial Registration
ClinicalTrials.gov NCT04698967; https://clinicaltrials.gov/ct2/show/NCT04698967

International Registered Report Identifier (IRRID)
PRR1-10.2196/47986
APPLICATION OF TIME SERIES CLUSTER ANALYSIS IN CLUSTERING THE CENTRAL JAVA PROVINCE BASED ON THE POVERTY DEPTH INDEX
Authors: Dien Rizqiana Zulfanita 
Published: June 2023

Poverty is a problem that continues to be faced, especially in developing countries such as Indonesia. Poverty is included in one of the Sustainable Development Goals (SDGs) programs, which is related to hunger and health. The time series data can be clustered based on the characteristics of the time series data and adjusted to the time series pattern. The choice of distance and method used must be adjusted to the dynamic structure of time series data. The purpose of this research is to cluster districts/cities in Central Java Province based on the poverty depth index value from 2017 to 2022. The variable that used in this research is the Poverty Depth Index of 35 districts in Central Java Province from 2017 to 2022. This research used cluster time series with DTW similarity measurment. Based on theDTW and cophenetic coefficient correlation value using three linkage methods, the average linkage method has the highest cophenetic coefficient correlation value of 0.8017988. Testing the quality of clusters using the silhouette coefficient using DTW distance and average linkage method and 2 clusters are included in the good cluster category with a silhouette coefficient value of 0.60. The resulting clusters using the DTW distance and average linkage method are cluster 1 consisting of 25 districts / cities and cluster 2 consisting of 10 districts.
Does Auditor Resilience Mitigate the Effects of Multiple Team Memberships on Quality Threatening Behaviors?
Authors: Zhang D. James , Veltrop Dennis B. , Hooghiemstra Reggy B. H. , Rink Floor 
Published: June 2023

SUMMARY
Audit firms rely on audit teams where memberships are frequently shared, shifted, and dissolved. In practice, this means that many auditors are part of multiple engagement teams for a given period of time. This paper examines why and when such multiple team memberships (MTMs) may lead auditors to engage in audit quality-threatening behaviors. We analyze data from a survey of 202 auditors—ranging from assistants to partners—working at Dutch audit firms. Our findings demonstrate that serving on MTMs can undermine auditor learning and in so doing leads auditors to engage in audit quality-threatening behaviors. Analyses show that less resilient auditors—those who are less able to bounce back from experienced difficulties—appear most susceptible to these deleterious effects. In addition, exploratory analyses suggest that the negative effect of serving on many MTMs appears to be more pronounced for field-level auditors than for management-level auditors.
More than Making Copies: Survey Evidence on the Work of Novice Auditors
Authors: Saunders K. Kelli , Keune Marsha B. , Hawkins Erin M. 
Published: June 2023

SUMMARY
The auditing landscape has changed dramatically in the last 20 years due to new standards, improved technology, internal shared services centers, and more. These institutional advances have altered the responsibilities of novice auditors. However, our knowledge of novice auditor task responsibilities and experiences has not been systematically updated in the 21st century. This study provides empirical evidence on the tasks and experiences of novice auditors by reporting survey responses from 104 audit interns, more than 30 intern supervisors, and 89 staff auditors. Our results shed light on the evolution of the roles of novice auditors by documenting the significant number and variety of tasks that they perform, as well as the interpersonal interactions, formal training, and other activities they commonly experience.
Data Availbility: Please contact the authors.
Tech Dump: Segment Analysis for a Social Enterprise
Authors: Grimm Stephanie D. 
Published: June 2023

ABSTRACT
Tech Dump is a social enterprise that operates an e-waste recycling business to support its mission of providing employment opportunities and job training for individuals with barriers to employment. Tumbling commodity prices have negatively impacted Tech Dump’s revenue, profits, and cash reserves. The weakened financial position has led the Tech Dump’s board of directors to question Tech Dump’s ability to meet its job training mission and commitment to sustainability with its current business model. Students are required to analyze segment contribution statements for the recycling and reuse segments and to discuss how the organization’s revenues, costs, and decisions are influenced by Tech Dump’s status as a social enterprise.
<strong>Unmasking Barriers in the Delivery of Preconception Counseling and Contraception Provision for Patients With Type 1 or Type 2 Diabetes</strong>
Authors: A. Abushamat Layla , Sayres Lauren , Jeffers Rebecca , Nielsen Chloe , A. Barbour Linda , Zaman Adnin 
Published: June 2023

<p> </p>
<p>Suboptimal glycemic control among women with type 1 or type 2 diabetes before conception and during the early part of pregnancy is a powerful risk factor for fetal anomalies, macrosomia, and stillbirth. Major congenital anomalies occur in up to 25–30% of infants of women with type 1 or type 2 diabetes (1). Hyperglycemia during fetal organogenesis (5–8 weeks after the last menstrual period) is a considerable teratogen, and, consequentially, the risk of fetal anomalies related to preexisting maternal diabetes can be reduced to background risk when glycemic control is at goal.</p>
Career Adabtability And Work Engagement In Gojek Driver
Authors: Ramadhan Feptiono Fitrah , Prahara Sowanya ardi 
Published: June 2023

The current research aims to examine the relationship between career adaptability and work engagement. The subjects in this study were 74 people who had the characteristics of a Gojek driver in Yogyakarta, who had worked for at least one year. How to take the subject using purposive sampling method. The data analysis technique used is the product moment correlation from Karl Pearson. Based on the results of data analysis obtained correlation coefficient (R) of 0.737 with p = 0,000 (p <0.05). These results show that there is a significant positive relationship between career adaptability with work engagement. This research increase work engagement by increasing and building an adabtability career, so that optimal performance can be created both from within and for the achievement of organizational or company goals.
PENGEMBANGAN MEDIA SPACE BOOK BERBASIS QR CODE MATERI TATA SURYA DENGAN PENGUATAN KARAKTER GEMAR MEMBACA PADA KELAS VI SEKOLAH DASAR
Authors: Fitriyan Zahra , Prasasti Pinkan Amita Tri , Agustianti Teguh Linda 
Published: July 2023

Learning media are tools used to deliver and clarify the material at once stimulate and motivate students to learn in order to achieve the learning process. The aim of research and development are to produce a valid, pratical, and interesting space book based on QR Code with the character of likes to read for learning solar system 6th grade elementary school 03 Candimulyo Madiun as media. The method was used research and development method of Dick & Carey. The results of the material expert is 90,6%, media expert 96,4%, and user 100%. Students respon of small scale test 100% and the character likes to read after used space book 92,2%. And then, students respon of large scale test 92,3% and the character likes to read 86,9%. Based on the results analysis of space book based on QR Code very suitable for learning solar system.
PENERAPAN PELAYANAN PUBLIK BERBASIS E-GOVERNANCE PADA ERA REVOLUSI INDUSTRI 4.0
Authors: Prihartono Djakit , Tuti Retnowati WD 
Published: June 2023

Penerapan pelayanan publik berbasis e-governance pada era revolusi industri 4.0 penting dilakukan untuk meningkatkan kualitas pelayanan publik secara efektif dan efisien. Hal ini dilakukan karena banyaknya permasalahan pelayanan publik yang tidak dapat diselesaikan seperti pelayanan publik kurang responsive, kurang informatif, kurang koordinasi dan lain sebagainya. Tujuan penelitian untuk mengetahui penerapan pelayanan publik berbasis e-governance pada era revolusi industri 4.0, manfaat penerapan dan hambatannya. Metode penelitian menggunakan pendekatan kualitatif dengan studi pustaka. Teknik pengumpulan data melalui studi pustaka yang berasal dari jurnal, artikel, prosiding dan lain sebagainya. Teknik analisis data yakni yaitu pengumpulan data, pengolahan data, penyajian data dan penarikan kesimpulan. Hasil penelitian menunjukkan bahwa penerapan pelayanan publik berbasis e-governance pada era revolusi industri 4.0 harus berdasarkan beberapa indikator diantaranya support, capacity dan value. Manfaat penerapan pelayanan publik berbasis e-governance pada era revolusi industri 4.0 yakni dapat meningkatkan efektivitas efisiensi dan mengurangi biaya, meningkatkan pelayanan, meningkatkan partisipasi masyarakat, meningkatkan transparansi dan mengurangi korupsi. Penerapan pelayanan publik berbasis e-governance pada era revolusi industri 4.0 tentunya memiliki beberapa hambatan diantaranya tangible, intangible dan very intangible.

Kata Kunci: Pelayanan Publik, E-governance, Revolusi Industri 4.0
Pola Penggunaan Obat pada Disabilitas Tunanetra: Kajian Naratif
Authors: Putri Dwi Resicha Adna , Dhamanti Inge 
Published: June 2023

Penggunaan obat merupakan salah satu kesulitan yang dialami oleh disabilitas tunanetra dalam meningkatkan kualitas kesehatannya. Tujuan penulisan artikel ini adalah untuk mengetahui pola penggunaan obat di kalangan penyandang disabilitas tunanetra. Metode yang digunakan dalam penulisan artikel ini adalah literature review. Pencarian artikel dilakukan melalui Google Scholar dan PubMed dengan kata kunci berupa medication problems, drug use, dan visual impairments. Jumlah artikel yang berhasil dikumpulkan sebanyak 292 artikel, namun hanya empat artikel yang termasuk dalam kriteria inklusi. Hasil penelitian menunjukkan bahwa terdapat dua pola penggunaan obat utama yang digunakan oleh disabilitas tunanetra, yaitu mengandalkan bantuan orang lain dengan penglihatan normal dan menerima obat sendiri. Kedua pola ini memberikan bentuk bantuan yang berbeda bagi disabilitas tunanetra untuk dapat menggunakan obat dengan cara yang benar.

The use of drugs is one of the difficulties experienced by the visually impaired in improving the quality of their health. The purpose of this review article is to find out the pattern of drug use among blind people with disabilities. The method used in writing this article is a literature review. Article searches were conducted through Google Scholar and PubMed with keywords such as medication problems, drug use, and visual impairments. The total number of articles found was 292, but only four articles met the inclusion criteria. The results showed that there were two main patterns of drug use for blind people, namely, relying on the help of others with normal vision and receiving the drug itself. These two patterns provide different forms of assistance for the visually impaired to use drugs in the right way.