bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of exosomal microRNA panel as diagnostic and prognostic biomarker for small cell lung cancer
Authors: Kim Dong Ha , Park Hyojeong , Choi Yun Jung , Im Kyungtaek , Lee Chae Won , Kim Da-Som , Pack Chan-Gi , Kim Hyun-Yi , Choi Chang-Min , Lee Jae Cheol , Ji Wonjun , Rho Jin Kyung 
Published: September 2023

Abstract
Background
Small cell lung cancer (SCLC) has an exceptionally poor prognosis; as most of the cases are initially diagnosed as extensive disease with hematogenous metastasis. Therefore, the early diagnosis of SCLC is very important and may improve its prognosis.

Methods
To investigate the feasibility of early diagnosis of SCLC, we examined exosomal microRNAs (miRNAs) present in serum obtained from patients with SCLC. First, exosomes were isolated in serum from patients with SCLC and healthy individuals and were characterized using particle size and protein markers. Additionally, miRNA array was performed to define SCLC-specific exosomal miRNAs. Second, the obtained miRNAs were further validated employing a large cohort. Finally, the ability to diagnose SCLC was estimated by area under the curve (AUC), and intracellular mRNA change patterns were verified through validated miRNAs.

Results
From the miRNA array results, we selected 51-miRNAs based on p-values and top 10 differentially expressed genes, and 25-miRNAs were validated using quantitative reverse transcription-polymerase chain reaction. The 25-miRNAs were further validated employing a large cohort. Among them, 7-miRNAs showed significant differences. Furthermore, 6-miRNAs (miR-3565, miR-3124-5p, miR-200b-3p, miR-6515, miR-3126-3p and miR-9-5p) were up-regulated and 1-miRNA (miR-92b-5p) was down-regulated. The AUC value of each miRNA sets between 0.64 and 0.76, however the combined application of 3-miRNAs (miR-200b-3p, miR-3124-5p and miR-92b-5p) remarkably improved the diagnostic value (AUC = 0.93). Gene ontology analysis revealed that the 3-miRNA panel is linked to various oncogene pathways and nervous system development. When the 3-miRNAs were introduced to cells, the resulting changes in total mRNA expression strongly indicated the presence of lung diseases, including lung cancer. In addition, the 3-miRNA panel was significantly associated with a poorer prognosis, although individual miRNAs have not been validated as prognostic markers.

Conclusion
Our study identified SCLC-specific exosomal miRNAs, and the 3-miRNAs panel (miR-200b-3p, miR-3124-5p and miR-92b-5p) may serve as a diagnostic and prognostic marker for SCLC.

Graphical abstract
The timing of drain removal in parotidectomies: Outcomes of removal at 4 h post-operatively and a Canadian survey of practice patterns
Authors: Liu Alice Q. , Butskiy Oleksandr , Cheung Veronique Wan Fook , Anderson Donald W. 
Published: September 2023

Background The post-operative management of parotidectomies is highly provider dependent. No guidelines are currently available for timing of parotid drain removal. This study aimed to assess: (1) outcomes and complications after early drain removal (< 4 h, post-operative day [POD] 0) versus late drain removal (POD ≥ 1); (2) current Canadian provider practices. Methods A single surgeons ten-year parotidectomy practice was reviewed, spanning his practice change from routine POD ≥ 1 drain removal to POD 0 removal, with extraction of patient demographic, disease, and complication variables. An anonymous, cross-sectional survey on parotid drain practices was distributed to Canadian Society of Otolaryngology-Head and Neck Surgery members. Descriptive statistics, Wilcoxon Rank Sum, and unpaired student's t-tests were calculated. Results In total, 526 patients were included and 44.7% (235/526) had drains removed POD 0. There was no significant difference in hematoma or seroma rates between the POD 0 and POD ≥ 1 drain removal cohorts. The national survey on parotid drain management had 176 responses. The majority (67.9%) reported routinely using drains after parotidectomy and 62.8% reported using a drain output based criteria for removal. The most common cut-off output was 30 ml in 24 h (range 5–70 ml). Conclusion There was no difference in hematoma or seroma rates for patients with parotid drains removed on POD 0 versus POD ≥ 1. Our national survey found significant variation in Canadian parotidectomy drain removal practices, which may be an area that can be further assessed to minimize hospital resources and improve patient care. Graphic abstract
Education on quality assurance and assessment in teaching quality of high school instructors
Authors: Chen Lei , Mohamed Mokhtar Mazlin 
Published: September 2023

AbstractResearch on language teaching quality has certainly stood out enough to be noticed as the momentum higher school teaching change proceeds to extend and develop. The way to further developing language teaching quality is to further develop teaching quality, and educator assessment is a significant instrument for doing as such. Accordingly, school administration necessitates the turn of events and refinement of a framework for assessing language teaching quality. Thus, hybrid learning technique for assessing the teaching quality of high school instructors should be created. We present an interesting model for assessing the quality of homeroom teaching involving artificial intelligence innovation in high schools, which depends on better hereditary calculations and neural networks. The fundamental thought is to utilize higher request factual elements (skewness, change, second and kurtosis), even vulnerability, Improved Independent Component Analysis (IICA), Holo-entropy based highlights to remove the underlying loads and limits of gathered data. The teaching quality assessment results were enhanced by further developing the neural network’s forecast accuracy and intermingling speed, bringing about a more down to earth plot for assessing high school language teaching quality. We have led simulation investigations and comparative analysis utilizing the Bi-directional Long Short Term Memory (Bi-LSTM) and Convolutional Neural Network (ConvNet/CNN) models. Then, an education quality assessment framework is laid out by hybrid optimizing model parameters which is Seagull Optimization Algorithm (SOA) and Red Colobuses Monkey (RCM).
Intensified extraction of anthocyanins from Berberis vulgaris L. by pulsed electric field, vacuum-cold plasma, and enzymatic pretreatments: modeling and optimization
Authors: Dara Arash , Feizy Javad , Naji-Tabasi Sara , Fooladi Ebrahim , Rafe Ali 
Published: September 2023

Abstract
Background
Berberis vulgaris L. is a valuable source of natural antioxidants, polyphenols, and anthocyanins compounds. Advanced extraction methods can increase extraction efficiency. This study investigated the efficiency of pulsed electric field, vacuum-cold plasma, and enzymatic pretreatment for anthocyanins extraction of Berberis vulgaris L.

Results
Total polyphenols (TP), total anthocyanin (TA), and physicochemical properties of Berberis vulgaris L. were investigated. The pulsed electric field at three levels of electric intensity (3000, 5000, and 7000 V/cm) and three pulse numbers (50, 75, and 100) were applied. 7000 V/cm with the pulse number of 100 was the best condition for anthocyanin extraction (amounts of anthocyanin and polyphenol extraction were 260.28 mg/L and 462.75 mg/L, respectively). The vacuum-cold plasma was carried out at the power of 60, 70, and 80 w at different times (1, 3, and 5 min). The optimum conditions for vacuum-cold plasma were 80 w for 5 min, and anthocyanin and polyphenol amounts were 256.32 mg/L and 433.71 mg/L, respectively. The optimal conditions of enzymatic pretreatment for the maximum yield were 1.5% enzyme concentration at 60 °C (the values of extracted anthocyanin and polyphenol were 279.64 mg/L and 484.93 mg/L, respectively).

Conclusions
Different extractionpretreatments demonstrated that the enzymatic pretreatment resulted in the highest extraction of anthocyanins and polyphenols from Berberis vulgaris L. Therefore, pectinase can act as a potential assisted extraction for the extraction process.

Graphical Abstract
The prevalence and multilevel analysis of minimum dietary diversity intake and its determinants among 6–23 months old infants in The Gambia: further analysis of the Gambian demographic and health survey data
Authors: Terefe Bewuketu , Jembere Mahlet Moges , Assimamaw Nega Tezera 
Published: September 2023

Abstract
Background
Poor infant and young child feeding (IYCF) practices are a significant issue both globally and in developing nations, and they have a significant role in undernutrition, healthy growth, and development, particularly in the first 2 years of life. Improving children's general health and wellbeing requires recognizing and decreasing preventable drivers of malnutrition. Hence, this study aimed to assess the prevalence and possible determinants of minimum dietary diversity among 6–23 months old babies in the Gambia.

Methods
Data from the 2019–2020 Gambia demographic and health survey were used. The study included a total of 2100 weighted 6–23 months old children. To identify characteristics significantly linked with minimum dietary diversity among infants, a multilevel fixed-effect analysis approach was used. After adjusting other confounding variables, variables with a p value of 0.25 were incorporated into a multivariable multilevel regression analysis to determine associated variables. An adjusted odds ratio with a 95% confidence interval was then applied.

Results
Only 22.22% (95% CI 18.55, 21.99) of infants had received the minimum dietary diversity. Mothers, who had mass media exposure (aOR = 2.71, CI = (1.02, 6.21), wealthier (aOR = 1.70, CI = 1.02, 2.85), child age of (aOR = 4.14, CI = 2.98, 5.76), and (aOR = 4.97, CI = 3.54, 6.98), have shown a positive statistical association with the outcome variable, respectively. Regarding regions mothers who came from Kanifing (aOR = 0.49, CI = 0.25, 0.94), Janjanbureh (aOR = 0.38, CI = 0.18, 0.82), and Basse (aOR = 0.51, CI = 0.26, 0.99) had showed less likelihood odds to provide the minimum dietary diversity (MDD) for their babies compared to Banjul local government area, respectively.

Conclusion
The World Health Organization dietary evaluation tool suggests that the MDD value be extremely low, even though it might be slightly higher than the numbers for some nations. The country may need to take drastic measures to tackle child malnutrition.
Fault location of untransposed double-circuit transmission lines based on an improved Karrenbauer matrix and the QPSO algorithm
Authors: Tang Minan , Lu Hang , Li Bin 
Published: September 2023

AbstractSome double-circuit transmission lines are untransposed, which results in complex coupling relations between the parameters of the transmission lines. If the traditional modal transformation matrix is directly used to decouple the parameters, it can lead to large errors in the decoupled modal parameter, errors which will be amplified in the fault location equation. Consequently, it makes the fault location results of the untransposed double-circuit transmission lines less accurate. Therefore, a new modal transformation method is needed to decouple the parameter matrix of untransposed double-circuit transmission lines and realize the fault location according to the decoupled modal parameter. By improving the basis of the Karrenbauer matrix, a modal transformation matrix suitable for decoupling parameters of untransposed double-circuit transmission lines is obtained. To address the difficulties in solving the fault location equation of untransposed double-circuit transmission lines, a new fault location method based on an improved Karrenbauer matrix and the quantum-behaved particle swarm optimization (QPSO) algorithm is proposed. Firstly, the line parameter matrix is decomposed into identical and inverse sequence components using the identical-inverse sequence component transformation. The Karrenbauer matrix is then transformed to obtain the improved Karrenbauer matrix for untransposed double-circuit transmission lines and applied to identical and inverse sequence components to solve the decoupled modal parameter. Secondly, based on the principle that voltage magnitudes at both ends are equal, the fault location equation is expressed using sequence components at each end, and the QPSO algorithm is introduced to solve the equation. Finally, the feasibility and accuracy of the proposed method are verified by PSCAD simulation. The simulation results fully demonstrate that the innovative improvement on the basis of the traditional modal transformation matrix in this paper can realize the modal transformation of the complex coupling parameters of the untransposed double-circuit transmission lines. It causes almost no errors in the decoupling process. The QPSO algorithm can also solve the fault location equation more accurately. The new fault location method can realize the accurate fault location of untransposed double-circuit transmission lines.
Health-related quality of life of Adolescent and Young Adult Cancer Survivors before and during the COVID-19 pandemic: longitudinal improvements on social functioning and fatigue
Authors: Vlooswijk Carla , Janssen Silvie H. M. , van de Poll-Franse Lonneke V. , Bijlsma Rhodé , Kaal Suzanne E. J. , Kerst J. Martijn , Tromp Jacqueline M. , Bos Monique E. M. M. , Lalisang Roy I. , Nuver Janine , Kouwenhoven Mathilde C. M. , van der Graaf Winette T. A. , Husson Olga 
Published: September 2023

AbstractThe health-related quality of life (HRQoL) among long-term Adolescent and Young Adult Cancer Survivors (AYACS) and an age- and sex-matched normative population was examined. Although the HRQoL of AYACS was worse compared to the normative population before and during the COVID-19 pandemic, the scores of AYACS improved over time in contrast to the normative population. Presumably, AYACS are used to adjusting their lives to stressful life events. Furthermore, the lockdown may have been beneficial for AYACS who face difficulties fully participating in society due to the impact of cancer. AYACS who encounter HRQoL issues could benefit from support interventions to empower them and build resilience.
Absence seizures in lesion-related epilepsy
Authors: Sun Xiaoqin , Wang Miao , He Zeng , Liu Lihong , Shi Xianjun , Zhang Chunqing , An Ning , Yang Meihua , Wu Zhifeng , Wang Ruodan , Wang Li , Wang Zhongke , Yang Hui , Yang Xiaolin , Liu Shiyong 
Published: September 2023

Abstract
Background
In the new International League Against Epilepsy (ILAE) classification of seizure types, generalized seizures such as absence seizures (ASs) may originate from a focal point and rapidly spread to the bilaterally distributed brain network. Increasing evidence from animal and clinical studies has indicated that focal changes may occur prior to ASs; however, the relationship of ASs with epileptogenic lesions remains unclear.

Methods
We retrospectively collected and analyzed the clinical, imaging, and electrophysiological data of 16 patients who had ASs and structural lesions with seizure-free outcomes after lesion resection.

Results
In semiology analysis, nine patients displayed focal onset; only two patients showed simple ASs, and seizure types other than ASs were observed in the remaining patients. On ictal electroencephalography (EEG), four patients showed bilateral synchronous symmetric 3 Hz generalized spike-wave discharges (GSWDs), and the remaining patients showed bilateral 1.5–2.5 Hz GSWDs. Moreover, most patients (13/16, 81.3%) exhibited focal features in addition to ASs, while interictal EEG was the same in 12 patients. Furthermore, on stereoelectroencephalogram (SEEG), 2/5 patients showed focal discharges before bilateral burst GSWDs. Additionally, all patients had structural lesions on imaging. In four typical AS patients, the lesions were located in deep brain regions. Notably, in 9 patients (9/16, 56%), the lesions were located in the posterior cortex. All patients underwent lesion resection and had seizure-free outcomes during follow-up, and intelligence quotient (IQ) also improved by 10.71 ± 3.90 one year after surgery.

Conclusions
Patients with lesion-related epilepsy may present with ASs that have a focal onset and are associated with good surgical outcomes.
Long-term follow-up of CT-guided percutaneous radiofrequency ablation of T1 renal cell carcinoma
Authors: Fouda Mohamed Elsayed Ahmed Abdou , Ghoneim Mahitab Mohamed Rashad , Settein Magdy Elsayed Mohamed , Tantawy Mohamed Salah Ibrahim , El-Diasty Tarek Abdelmoneim 
Published: September 2023

Abstract
Background
Radiofrequency ablation (RFA) has an established role in effective treatment of renal cell carcinomas (RCCs), as most of RCCs are diagnosed incidentally in early stages. Long-term follow-up is however important to consolidate the technique. Most of the literature contains series of short-term follow-ups of periods shorter than 2 years. This study in hand demonstrates the results of longer-term follow-up than the previously published series.

Results
Data analysis of 31 patient records involved in this study demonstrated the high clinical efficacy of RFA for long term, 12-year follow-up, by following the absence of tumor recurrences, as shown on regular interval contrast enhanced computed tomography (CT) and or magnetic resonance imaging (MRI).

Conclusions
RFA continues to prove its competent role in treating RCCs on longer-term follow-ups; the smaller the size of a tumor and the more peripheral the tumor is, the more effective the therapy. Even in larger early stages tumors, repeating the ablative sessions results in complete ablation without the need for more invasive surgical interventions.
Type B Insulin Resistance Syndrome: A Rare Cause of Hypoglycemia
Authors: Bhat Salman Zahoor , Lim Sooyoung , Sidhaye Aniket , Hamrahian Amir H 
Published: September 2023

Abstract
We describe a case of a Black female patient with a history of type 2 diabetes mellitus and systemic lupus erythematosus, who had a subacute onset of severe hypoglycemia that persisted after cessation of insulin therapy. Biochemical testing revealed hyperinsulinemic hypoglycemia, normal serum triglycerides, and high-normal serum adiponectin levels. Abdominal imaging demonstrated an 11-mm cystic pancreatic lesion. Her clinical history and biochemical test results raised suspicion for type B insulin resistance syndrome (TBIRS), which was confirmed on anti-insulin receptor antibody testing. The patient's hypoglycemia was managed with dietary modification therapy and continuous glucose monitoring. The severity and frequency of hypoglycemic episodes decreased spontaneously. We describe TBIRS and its uncommon hypoglycemic presentation, analyze factors that put TBIRS among the differential diagnosis, and discuss the treatment of TBIRS-associated hypoglycemia.
Afro-Asian Antagonism and the Long Korean War
Authors: Abe Kodai 
Published: September 2023

AbstractAmerican racial politics during the long Korean War formed what this essay terms Afro-Asian antagonism, a racial hate between African Americans and Asians (and Asian Americans). When the Truman administration issued Executive Order 9981 and proclaimed its commitment to military racial integration in 1948, two years before the outbreak of the Korean War, it seemed to signal a significant step of racial progress. Black servicemen who enlisted in the “liberalized” military, however, were strategically deployed to represent American national violence, especially to the eyes of Asians who were internalizing antiblack racism imported from the United States through the military apparatus. In the face of decolonization and an upsurge in civil rights movements, this article argues, the executive order molded Black Korean War veterans into an instrument to abort Afro-Asian connections while promoting racial liberalism to a global audience. The Korean War inaugurated the American Cold War racial formation that endures into the twenty-first century. Contrasting two Korean War novels written by Asian American and African American authors—Nora Okja Keller’s Fox Girl (2002) and Toni Morrison’s Home (2012)—this article traces how Afro-Asian orphans and a Black veteran internalize and challenge the Afro-Asian antagonisms of the long Korean War.
Polycomb safeguards imaginal disc specification through control of the Vestigial–Scalloped complex
Authors: Brown Haley E. , Weasner Brandon P. , Weasner Bonnie M. , Kumar Justin P. 
Published: September 2023

ABSTRACT
A fundamental goal of developmental biology is to understand how cell and tissue fates are specified. The imaginal discs of Drosophila are excellent model systems for addressing this paradigm as their fate can be redirected when discs regenerate after injury or when key selector genes are misregulated. Here, we show that when Polycomb expression is reduced, the wing selector gene vestigial is ectopically activated. This leads to the inappropriate formation of the Vestigial–Scalloped complex, which forces the eye to transform into a wing. We further demonstrate that disrupting this complex does not simply block wing formation or restore eye development. Instead, immunohistochemistry and high-throughput genomic analysis show that the eye-antennal disc unexpectedly undergoes hyperplastic growth with multiple domains being organized into other imaginal discs and tissues. These findings provide insight into the complex developmental landscape that tissues must navigate before adopting their final fate.
Genetic Predisposition, Sedentary Behavior, and Incident Coronary Artery Disease: A Prospective Chinese Cohort Study
Authors: HU CHUNYU , HUANG KEYONG , CAI CAN , LIU FANGCHAO , LI JIANXIN , HU DONGSHENG , ZHAO YINGXIN , LIU XIAOQING , CAO JIE , CHEN SHUFENG , LI HONGFAN , YU LING , LI YING , SHEN CHONG , HUANG JIANFENG , GU DONGFENG , LU XIANGFENG 
Published: September 2023

ABSTRACT

Purpose
Whether the association of sedentary behaviors with coronary artery disease (CAD) can be influenced by genetic susceptibility remains unclear. We aimed to investigate the joint and interplay effects between genetic risk and sedentary time (ST) and to further explore the extent to which the risk for CAD can be counteracted by reducing ST in different genetic groups.

Methods
This prospective cohort study included 39,164 Chinese adults without CAD history. Genetic susceptibility was quantified by a predefined polygenic risk score (PRS) with 540 genetic variants, and daily ST was assessed by questionnaire. We analyzed the modification effect of genetic risk on the association of ST with CAD using the Cox proportional hazards models.

Results
During a median follow-up of 11.60 yr, 1156 CAD events were documented. Higher ST and PRS were separately related to elevated CAD risk. Significant additive interaction was also observed (relative excess risk due to interaction: 0.77; 95% confidence interval [CI] = 0.27–1.28). Compared with participants with low genetic risk and low ST (<6 h·d−1), those with high genetic risk and high ST (≥10 h·d−1) had the highest CAD risk, with the hazard ratio (HR) and 95% CI of 4.22 (2.65–6.71). When stratified by genetic risks, participants with high ST had gradient increment of CAD risks across low, intermediate, and high genetic risk groups, with HR (95% CI) values of 1.21 (0.61–2.40), 1.57 (1.14–2.16), and 2.15 (1.40–3.31), respectively. For the absolute risk reduction, individuals with high genetic risk achieved the greatest benefit from low ST (P
trend = 0.024).

Conclusions
Genetic susceptibility may synergistically interact with ST to increase CAD risk. Reducing ST could attenuate the CAD risk, especially among individuals with high genetic risk.