bluuebunny/crossref_metadata_2025_split huggingface dataset:
Correlated Excitonic Signatures in a Nanoscale van der Waals Antiferromagnet
Authors: Htoon Han , Chandrasekaran Vigneshwaran , DeLaney Christopher , Parobek David , Lane Christopher , Zhu Jian-Xin , Li Xiangzhi , Zhao Huan , Trinh Cong , Campbell Marshall , Jones Andrew , Schneider Matthew , Watt John , Pettes Michael , Ivanov Sergei , Piryatinski Andrei , Dunlap David 
Published: May 2023

Abstract
Composite quasi-particles with emergent functionalities in spintronic and quantum information science can be realized in correlated materials due to entangled charge, spin, orbital, and lattice degrees of freedom.1-3 Here we show that by reducing the lateral dimension of correlated antiferromagnet NiPS3 flakes to tens of nanometers, we can switch-off the bulk spin-orbit entangled exciton in the near-infrared (1.47 eV)4-6 and activate visible-range (1.8 – 2.2 eV) transitions with charge-transfer character. These ultra-sharp lines (<120 meV at 4.2 K) share the spin-correlated nature of the bulk exciton by displaying a Néel temperature dependent linear polarization. Furthermore, exciton photoluminescence lineshape analysis reveals a polaronic character via coupling with at-least 3 phonon modes and a comb-like Stark effect through discretization of charges in each layer. These findings augment the knowledge on the many-body nature of excitonic quasi-particles in correlated antiferromagnets and also establish the nanoscale platform as promising for maturing integrated magneto-optic devices.
Double Positive of Anti-contactin-1 Antibody and Anti-ganglioside Antibodies related Chronic Inflammatory Demyelinating Polyradiculoneuropathy: a Case Report
Authors: Zhao Min , Chen Guixian , Li Xiaojun , Chen Haoxuan , Lou Zhenzhen , Ouyang Huiying , Zhan Yibo , Du Chenghao , Zhao Yuanqi , Qin Lulu 
Published: May 2023

Abstract
Background：Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is a crippling sickness that worsens over time. Contactin-1(CNTN1) antibody-related CIDP was rare and exhibited distinct clinical symptoms such as a later onset, subacute onset of weakness, sensory ataxia, and tremors. The mechanism of the unusual symptoms remained unknown. So far, no instance of anti-CNTN1 antibody-positive CIDP with anti-ganglioside antibodies (aGAAb) has been reported.
Case Presentation: We reported a rare case of anti-CNTN1 antibodies and aGAAb linked CIDP with two episodes. In the first episode, a 45-year-old woman was admitted to our hospital with primary complaint of arm numbness, weakness, and oedema in the lower limb. The physician considered the diagnosis of CIDP after clinical examination. Patient’s symptoms improved after taking prednisolone. Eleven years later, the symptoms were numbness and weakness in all four limbs, accompanied by tremors, which had rapidly deteriorated for nearly 3 years. The protein concentration in CSF was 1344 mg /L, and the white blood cells count was 5 × 106 /L. The serum CNTN1 antibody was positive, with a titer of 1:1000+. Anti-GT1a and anti-GQ1b antibodies in serum were shown to be double positive. There were no evident abnormalities in the brain MRI, brachial plexus, or lumbosacral MRI. Neurophysiological examination indicated that the electrophysiological shift was worse than previously. At the time, she was diagnosed with CIDP caused by the anti-contactin-1 autoantibody and double-positive anti-ganglioside antibodies. Numbness and weakness in the lower extremities were somewhat relieved after plasmapheresis therapy. However, she could still not walk without assistance two weeks after being discharged from hospital.
Conclusion：We presented a rare case of double positive of anti-CNTN1 antibody and aGAAb associated CIDP. The mechanism of tremors in patients with positive CNTN1 antibodies, as well as the relationship between aGAAb and CIDP, should be studied further.
Association of lncRNA EIF3J-AS1 with target gene IGFB3 polymorphisms in susceptibility of gastric cancer
Authors: Pan Huiwen , Xu Jia , Tang Weifeng , Zhu Jingfeng , Long Tao , Fang Zhijie , Chen Shuchen , chen Keping 
Published: May 2023

Abstract
LncRNA EIF3J-AS1 has shown to play an important regulatory role in a variety of tumor tissues, IGFB3 Gene is the target gene of LncRNA EIF3J-AS1, experimental studies shows that IGFB3 gene risk typing is associated with an increased risk of gastric cancer susceptibility of gastric cancer(GC),the relationship between LncRNA EIF3J-AS1 target IGFB3 Gene polymorphisms expression in GC patients is related. Methods: A case-controlled study was conducted, including 490 primary gastric cancers and 1476 normal controls. Targetscan, miRanda and other software are used to target and predict the genes and mirnas that lncRNA can bind to, and the expression correlation analysis is conducted, so as to construct the ceRNA network and speculate its regulation of gastric cancer expression. The target gene IGFB3 fragment was amplified in blood samples using PCR. Genotyping was performed using the snapshot method. Results: This rearch shows a signal pathway LncRNA EIF3J-AS1-IGFBP3, in IGFBP3 gene variants GA and GA + AA models, castric cancer can be decreased when in male subgroup and ≥ 61 years old subgroup, but during smoking and alcohol groups, gastic cancer risk is encreased. IGFBP3 gene is regulated by LncRNA EIF3J-AS1-miRNAs-IGFBP3 network, which could provide a potential drug target biomarker.
Reduced metabolic capacity of the gut microbiota associates with host growth in broiler chickens
Authors: Marcos Sofia , Odriozola Iñaki , Eisenhofer Raphael , Aizpurua Ostaizka , Tarradas Joan , Martin Garazi , Estonba Andone , Gilbert M Thomas P , Kale Varsha , Baldi Germana , Finn Robert , Mak Sarah , Alberdi Antton 
Published: May 2023

Abstract
Understanding the development of functional attributes of host-associated microbial communities is essential for developing novel microbe-based solutions for sustainable animal production. We applied multi-omics to 388 broiler chicken caecal samples to characterise and model the functional dynamics of 822 bacterial strains. Although microbial community diversity metrics increased with chicken age as expected, the overall metabolic capacity and activity of the microbiota exhibited an unexpected decrease. This drop occurred due to the spread of non-culturable clades with small genomes and low metabolic capacities, including RF39, RF32, and UBA1242. The intensity of this decrease was associated with animal growth, whereby chickens with higher abundances of low-capacity bacteria exhibited higher body weights. This previously unreported link between metabolic capacity of microbes and animal body weight suggests a relevant role of non-culturable bacteria with reduced-genomes for host biology, and opens new avenues in the search for microbe-based solutions to improve sustainability of animal production.
Targeted metabolomics analysis of the branched-chain amino acids of adolescent obesity: a development of nomogram in girls
Authors: Tao Junmin , Cheng Yuan , Zhang Kangshuai , Liu Yang , Huo Yingxiang , Li Xiaofeng , Chen Xin 
Published: May 2023

Abstract
Background
Targeted metabolomics analysis was applied to explore the association of BCAAs and adolescent obesity, developed and validated a nomogram model to predict the adolescent obesity risk.
Methods
104 adolescents aged 16–17 years were included. Liquid chromatography coupled with mass spectrometry was performed to measure BCAAs levels. Body mass index (BMI), waist circumference and waist-to-height ratio (WHtR) were used to measure obesity. Univariate logistic regression was performed to estimate obesity related factors, restricted cubic spline was used to test the potential non-linear relationship between obesity and BCAAs. The risk nomogram based on multivariate logistic regression analysis was developed and validated.
Results
After adjusting for obesity related factors, only val showed a significant non-linear association with BMI in girls (P = 0.012). Val, age, systolic blood pressure, high-density lipoprotein cholesterol, urea, uric acid and apolipoprotein A1 were extracted to develop the nomogram model, the area under the receiver operating characteristic curve was 0.900. Hosmer-Lemeshow test showed a high goodness-for-fit, and decision curve analysis showed that the nomogram has good clinical utility.
Conclusions
BCAAs levels in adolescents were sex-dependent. The validated nomogram model can provide guidance for clinical decision-making and val can used as an essential biomarker to predict early obesity in girls.
The impact of COVID-19 pandemic on outcomes of women with breast cancer recurrence
Authors: Mühlmann Lindson , Pimentel Franklin Fernandes , Tiezzi Daniel Guimarães , Carrara Hélio Humberto Angotti , de Andrade Jurandyr Moreira , Reis Francisco Jose Candido dos 
Published: May 2023

Abstract
Purpose
The COVID-19 pandemic has impacted the management of several diseases. Our goal was to assess the outcomes of women diagnosed with relapsed breast cancer during the pandemic period.
Methods
We evaluated a cohort of 187 women with breast cancer recurrence out of a total of 2,891 patients diagnosed with breast cancer between January 2011 and March 2022.
Results
At the time of recurrence diagnosis, 116 patients (62%) had distant metastasis and 71 (38%) had local recurrence. Of the women with initial local recurrence, 28% (35) died, while 72% (91) of the women with distant recurrence died. The pandemic group showed a significant decrease in overall survival (OS) compared to the pre-pandemic group (median 9 months versus 22 months, respectively; HR: 1.92; 95% CI: 1.19–3.12).
Conclusion
The pandemic had a negative impact on the survival of patients with breast cancer recurrence.
Vermistabilization: a sustainable strategy for the bioconversion and detoxification of textile industry sludge
Authors: Selvam Ramu , Bankole Paul Olusegun , PhD  , Sadasivam Senthil Kumar 
Published: May 2023

Abstract
Vermistabilization of the textile industrial sludge (TS) was carried out on a pilot scale with the help of the earthworm Eudrilus eugeniae. TS was mixed with cow dung (CD) in a ratio of 1:1 and thereafter subjected to vermicomposting for 90 days. Earthworms’ weights increased significantly by 55% in the feed mixture within 45 days of inoculation. Physicochemical parameters significantly reduced during vermicomposting (pH, EC, TDS, TOC, and NH3-N) whereas TKN, TP, TK were found to be significantly elevated in the final product. Except for Mn and Zn, the addition of amendments increased earthworm activity, which greatly reduced the content of heavy metals (Al, As, Cd, Cu, Pb, Ni, Cr, Mo, and Hg). Germination index (100%) of Brassica nigra was recorded in the feed mixture. The shoot and root length ranged from 2.26 and 4.36 after 90 days. Genotoxicity analysis revealed a 9.45–10.40% reduction in aberration frequencies of vermistabilized extracts in comparison with control (extracts of TS and CD only). The present study concluded that the deployment of vermistabilized extracts looks promising as a sustainable waste disposal management technology.
DUSP1 regulates the induction of Staphylococcus aureus-mediated apoptosis in THP-1 macrophage cells
Authors: Liu Zhanyou , Dai Fan , Zhang Xuyang , Zhang Dongtao , Li Zhiying , Li Wu 
Published: May 2023

Abstract
Staphylococcus aureus (S. aureus) is a major human pathogen that causes apoptosis of immune cells during infections. The rate of apoptosis influences the severity and outcome of the disease, which can be fatal for infections including sepsis and septicemia. Dual specificity phosphatase-1 (DUSP1) is a negative regulator of MAPK signaling pathways in the host innate immune response, but its role in S. aureus-induced apoptosis remains unexplored. We used western blotting and immunofluorescence assays to show that S. aureus infection induced DUSP1 expression and promoted apoptosis in THP-1 cells. Knockdown of DUSP1 using an siRNA construct promoted the expression of key pro-apoptotic proteins, including cleaved-caspase3, cleaved-PARP1, cleaved-caspase9, cytochrome c and bax, whereas it inhibited the expression of key apoptosis inhibitory proteins bcl-2 and bcl-XL. These results were validated by flow cytometry. In addition, knockdown of DUSP1 promoted the accumulation of reactive oxygen species in S. aureus-induced macrophages, and mechanistically, knockdown of DUSP1 promoted the phosphorylation of target molecules in the MAPK signaling pathway, thereby promoting apoptosis in S. aureus-infected THP-1 macrophages. These data support a regulatory role for DUSP1 in S. aureus-mediated apoptosis and we suggest that DUSP1 be investigated as an anti-apoptotic therapeutic target.
The simulation training program of laparoscopic enteroenteric anastomosis on a 3D- printed model and the effect of left-hand dexterity training on this training
Authors: Zhu Zhihao , Mao Jinlei , Chen Hao , Cao Lidong , Xia Jianfu , Yang Jin , Wang Zhifei 
Published: May 2023

Abstract
Background In surgery, most right-handed people don't have enough left-hand dexterity. We would like to utilize a convenient way to improve left-hand dexterity and study whether it could enhance the effectiveness of surgical training.
Methods Four residents were randomly divided into two groups. The subjects in the study group were required to use the left-hand computer mouse for 15 minutes every day for 30 days. The hand dexterity of all subjects was tested through the O’Conner Tweezer Dexterity Test and their performance of enteroenteric anastomosis on a specific 3D printed model was recorded and evaluated by Objective Structured Assessment of Technical Skill and Specific Rating Scales every time they train.
Results The average time for the left-handed test in the experimental group and control group was from 518.5s to 343s and from 531s to 444.5s respectively. There was a statistically significant difference in left-hand dexterity between the two groups (P=0.015).
The average performance score of the experimental group and control group improved from 25.5 to 42 and from 24.5 to 31.5 respectively. There was a statistically significant difference in training performance between the two groups in the 4th (P=0.014) and 5th (P=0.008) tests.
A figure about left-hand dexterity score and operation performance scores (Learning curve) was made. A table and a figure about the operation details in training were made.
Conclusion Regular surgical training on 3D printed models can improve suture performance while improving left-hand dexterity with a left-handed mouse can speed up the process and shorten the learning curve.
Climate warming contributes to the record-shattering 2022 Pakistan rainfall
Authors: Ting Mingfang , Biasutti Michela , You Yujia 
Published: May 2023

Abstract

A sequence of torrential rainstorms pounded Pakistan in the summer of 2022, shattering records by massive margins (7 sigma). The severe socioeconomic damages underscore the urgency of identifying its dynamic drivers and relationship with human-induced climate change. Here, we find that the downpours were primarily initiated by the synoptic low-pressure systems, whose intensity and longevity far exceeded their counterparts in history as fueled by a historically-high cross-equatorial moisture transport over the Arabian Sea. The moisture transport has been trending upward since the 1960s and, in 2022, along with the anomalous easterly moisture influx caused by the combination of La Niña and negative Indian Ocean Dipole events, created a corridor of heavy rainfall extending from central India toward southern Pakistan. While it is not yet established whether the observed trend of the cross-equatorial moisture transport has exceeded natural variability, model-based analysis confirms that it is consistent with the fingerprint of anthropogenic climate warming and will raise the likelihood of such rare events substantially in the coming decades.
Impact of Cold Plasma on Structural, Morphological, and Dielectrical Characteristics of Nanocomposites (PVA/PAA/Ag) Films
Authors: Obeid Zahraa Hasson , Rabee Bahaa H. 
Published: May 2023

Abstract

A nanocomposites of (PVA/PAA/Ag) was prepared by casting method in different concentration of the nanomaterial (Ag) represented by (0, 2, 4, 6, and 8( wt.%. The structural, morphological, and electrical characteristic were studied. The optical microscope (OM) proved the Ag NPs create a continuous network within the blend and the formation of pits and grooves, which indicates sufficient energy in the Ar plasma gas to extract this substance which noted at (PVA/PAA/8wt.% Ag) nanocomposites. The FTIR spectrum of the functional collections existing in polymer nanocomposite systems were established, and changes in shifting and transmittance were observed as a effect of the adding of Ag NPs. The (PVA/PAA/Ag) nanocomposites films have a homogenous and coherent surface morphology, as revealed by SEM. Argon plasma species on the (PVA/PAA) surface provide a progressive impression, which leads to a diverse morphology. Dielectric constant, dielectric loss, and alternating current (A.C) electrical conductivity of (PVA/PAA/Ag) nanocomposites are found to rise with rising concentrations of Ag NPs, while decreasing with increasing frequency. Plasma interaction with the molecular structure of these nanocomposites results in increased values for the dielectric constant, dielectric loss, and alternating current (A.C.) electrical conductivity following irradiation. Finally, the results demonstrated that cold plasma's impact on nanocomposites could produce materials with broad applications in nanodevices for cutting-edge electronics.
Molecular evaluation and genetic diversity of bovine tick-borne pathogens in southern Malawi
Authors: Xuan Xuenan , Chikufenji Boniface , Galon Eloiza May , Chatanga Elisha , Kamanga Nathan , Mohanta Uday Kumar , Ma Zhuowei , Hayashida Kyoko 
Published: May 2023

Abstract
Purpose: Tick-borne disease (TBD) prevention and control is dependent on a thorough understanding of disease vectors and pathogens. In Malawi, there is little information on molecular investigations of cattle tick-borne pathogens (TBPs). This study aimed to detect TBPs infecting cattle in southern Malawi which has the highest cattle population in Malawi.
Materials and Methods: A total of 220 apparently healthy cattle blood samples were collected in 6 southern Malawi districts. Detection of TBPs was done using polymerase chain reaction (PCR) tests with species-specific primers.
Results: A 72.3% overall infection rate (159/220) was recorded, with Anaplasma marginale (51/220, 23.2%), A. bovis (21/220, 9.6%), A. phagocytophilum (49/220, 22.3%), Babesia bigemina (76/220, 34.5%), B. bovis (16/220, 7.3%), B. naoakii(6/220, 2.7%), Theileria parva (34/220, 15.5%), T. mutans, (9/220, 4.1%), and T. taurotragi (49/220, 22.3%) as the detected pathogens.
Conclusion: The study reports B. naoakii, and B. bovis for the first time in cattle from Malawi. The study provides essential information on the distribution of TBDs and for carrying out potential control efforts in Malawi.
Identification of NK cell to predict prognosis in extensive-stage small cell lung cancer patients treated with immunotherapy plus chemotherapy
Authors: Cui Yanan , Zhao Peiyan , Li Shuang , Cheng Ying , Ren Xiubao 
Published: May 2023

Abstract
Background
Although the combination of immunotherapy and chemotherapy has emerged as a new standard for the first-line treatment of extensive-stage small cell lung cancer (ES-SCLC), there remains a dearth of prognostic markers of this novel therapeutic approach. In this study, we aimed to evaluate the efficacy of immunotherapy plus chemotherapy in patients with ES-SCLC and explore the potential prognostic markers.
Methods
Pathologically confirmed ES-SCLC patients receiving immunotherapy plus chemotherapy as the first-line treatment were enrolled between July 2020 and August 2022 in this retrospective study. The natural killer (NK) cells in peripheral blood was collected at sequential time points. Kaplan-Meier method and log-rank test were utilized to calculate progression-free survival (PFS) and overall survival (OS). The prognostic value of the percentage of NK cells was evaluated by Cox proportional hazards regression analyses.
Results
A total of 33 patients with ES-SCLC treated with immunotherapy plus platinum-etoposide were included for the analysis. At the time of data cutoff, the median PFS was 5.6 months and the median OS was 13.9 months. It was found that the percentage of NK cells at baseline was an independent factor of PFS(HR 0.142; 95% CI, 0.053–0.377; P＜0.001), and the difference between NK cell percentage at the time of optimal efficacy and baseline was an independent predictor factor of OS(HR 0.375; 95% CI, 0.169–0.832; P = 0.016).
Conclusions
The study demonstrated that NK cells in peripheral blood could be used as a novel and convenient biomarker to predict the prognosis of patients with ES-SCLC treated with immunotherapy plus chemotherapy,which has significant implications for informing treatment decisions.
Diffusion Tensor Imaging helps identify shunt-responsive Normal Pressure Hydrocephalus patients amongst probable iNPH cohort
Authors: Sedlák Vojtěch , Bubeníková Adéla , Skalický Petr , Vlasák Aleš , Whitley Helen , Netuka David , Beneš Vladimír , Beneš Vladimír , Bradáč Ondřej 
Published: May 2023

Abstract
Objectives
The aim of this study was to investigate whether white matter changes as measured by Diffusion Tensor Imaging (DTI) can help differentiate shunt-responsive idiopathic normal pressure hydrocephalus (iNPH) patients from patients with other causes of gait disturbances and/or cognitive decline with ventriculomegaly whose clinical symptoms do not improve significantly after cerebrospinal fluid derivation (non-iNPH).
Methods
Between 2017 and 2022, 85 patients with probable iNPH underwent prospective preoperative magnetic resonance imaging (MRI) and comprehensive clinical workup. Patients with clinical symptoms of iNPH, positive result on lumbar infusion test and gait improvement after 120-hour lumbar drainage were diagnosed with iNPH and underwent shunt-placement surgery. Fractional anisotropy (FA) and mean diffusivity (MD) values for individual regions of interest were extracted from preoperative MRI, using the TBSS pipeline of FSL toolkit. These FA and MD values were then compared to results of clinical workup and established diagnosis of iNPH. An identical MRI protocol was performed on 13 age- and sex-matched healthy volunteers.
Results
Statistically significant differences in FA values of several white matter structures were found not only between iNPH patients and healthy controls, but also between iNPH and non-iNPH patients. ROI that showed best diagnostic ability when differentiating iNPH amongst probable iNPH cohort was uncinate fasciculus, with AUC of 0.74 (p < 0.001).
Conclusion
DTI methods of white matter analysis using standardised methods of ROI extraction can help in differentiation of iNPH patients not only from healthy patients, but also from patients with other causes of gait disturbances with cognitive decline and ventriculomegaly.