bluuebunny/crossref_metadata_2025_split huggingface dataset:
Wearable and Implantable Cortisol‐Sensing Electronics for Stress Monitoring
Authors: Ok Jehyung , Park Sumin , Jung Yei Hwan , Kim Tae‐il 
Published: March 2023

AbstractCortisol is a steroid hormone that is released from the body in response to stress. Although a moderate level of cortisol secretion can help the body maintain homeostasis, excessive secretion can cause various diseases, such as depression and anxiety. Conventional methods for cortisol measurement undergo procedures that limit continuous monitoring, typically collecting samples of bodily fluids, followed by separate analysis in a laboratory setting that takes several hours. Thus, recent studies demonstrate wearable, miniaturized sensors integrated with electronic modules that enable wireless real‐time analysis. Here, the primary focus is on wearable and implantable electronic devices that continuously measure cortisol concentration. Diverse types of cortisol‐sensing techniques, such as antibody‐, DNA‐aptamer‐, and molecularly imprinted polymer‐based sensors, as well as wearable and implantable devices that aim to continuously monitor cortisol in a minimally invasive fashion are discussed. In addition to the cortisol monitors that directly measure stress levels, other schemes that indirectly measure stress, such as electrophysiological signals and sweat are also summarized. Finally, the challenges and future directions in stress monitoring and management electronics are reviewed.
Superlattice Nanofilm on a Touchscreen for Photoexcited Bacteria and Virus Killing by Tuning Electronic Defects in the Heterointerface
Authors: Li Jun , Wang Chaofeng , Wu Shuilin , Cui Zhenduo , Zheng Yufeng , Li Zhaoyang , Jiang Hui , Zhu Shengli , Liu Xiangmei 
Published: March 2023

AbstractCurrently, the global COVID‐19 pandemic has significantly increased the public attention toward the spread of pathogenic viruses and bacteria on various high‐frequency touch surfaces. Developing a self‐disinfecting coating on a touchscreen is an urgent and meaningful task. Superlattice materials are among the most promising photocatalysts owing to their efficient charge transfer in abundant heterointerfaces. However, excess electronic defects at the heterointerfaces result in the loss of substantial amounts of photogenerated charge carrier. In this study, a ZnOFe2O3 superlattice nanofilm is designed via atomic layer deposition for photocatalytic bactericidal and virucidal touchscreen. Additionally, electronic defects in the superlattice heterointerface are engineered. Photogenerated electrons and holes will be rapidly separated and transferred into ZnO and Fe2O3 across the heterointerfaces owing to the formation of ZnO, FeO, and ZnFe covalent bonds at the heterointerfaces, where ZnO and Fe2O3 function as electronic donors and receptors, respectively. The high generation capacity of reactive oxygen species results in a high antibacterial and antiviral efficacy (>90%) even against drug‐resistant bacteria and H1N1 viruses under simulated solar or low‐power LED light irradiation. Meanwhile, this superlattice nanofilm on a touchscreen shows excellent light transmission (>90%), abrasion resistance (106 times the round‐trip friction), and biocompatibility.
Single‐Layer Blue Organic Light‐Emitting Diodes With Near‐Unity Internal Quantum Efficiency
Authors: Sachnik Oskar , Li Yungui , Tan Xiao , Michels Jasper J. , Blom Paul W. M. , Wetzelaer Gert‐Jan A. H. 
Published: March 2023

AbstractEfficient organic light‐emitting diodes (OLEDs) commonly comprise a multilayer stack including charge‐transport and charge‐ and exciton‐blocking layers, to confine charge recombination to the emissive layer. Here, a highly simplified single‐layer blue‐emitting OLED is demonstrated based on thermally activated delayed fluorescence with the emitting layer simply sandwiched between ohmic contacts consisting of a polymeric conducting anode and a metal cathode. The single‐layer OLED exhibits an external quantum efficiency of 27.7% with minor roll‐off at high brightness. The internal quantum efficiency approaches unity, demonstrating that highly simplified single‐layer OLEDs without confinement layers can achieve state‐of‐the‐art performance, while greatly reducing the complexity of the design, fabrication, and device analysis.
Photosensitive Dielectric 2D Perovskite Based Photodetector for Dual Wavelength Demultiplexing
Authors: Qiao Bao‐Shi , Wang Su‐Yun , Zhang Zhi‐Hong , Lian Zhen‐Dong , Zheng Zhi‐Yao , Wei Zhi‐Peng , Li Lin , Ng Kar Wei , Wang Shuang‐Peng , Liu Zhi‐Bo 
Published: March 2023

AbstractStacked 2D perovskites provide more possibilities for next generation photodetector with more new features. Compared with its excellent optoelectronic properties, the good dielectric performance of metal halide perovskite rarely comes into notice. Here, a bifunctional perovskite based photovoltaic detector capable of two wavelength demultiplexing is demonstrated. In the Black Phosphorus/Perovskite/MoS2structured photodetector, the comprehensive utilization of the photosensitive and dielectric properties of 2D perovskite allows the device to work in different modes. The device shows normal continuous photoresponse under 405 nm, while it shows a transient spike response to visible light with longer wavelengths. The linear dynamic range, rise/decay time, and self‐powered responsivity under 405 nm can reach 100, 38 µs/50 µs, and 17.7 mA W‐1, respectively. It is demonstrated that the transient spike photocurrent with long wavelength exposure is related to the illumination intensity and can coexist with normal photoresponse. Two waveband‐dependent signals can be identified and used to reflect more information simultaneously. This work provides a new strategy for multispectral detection and demultiplexing, which can be used to improve data transfer rates and encrypted communications. This work mode can inspire more multispectral photodetectors with different stacked 2D materials, especially to the optoelectronic application of the wide bandgap, high dielectric photosensitive materials.
Flexible Acid‐Responsive Polymeric Phosphorescent Microfibers for Tunable Optical Waveguide
Authors: Zhang Hongli , Yang Cui , Zhong Hua , Wang Feng , Zou Gang 
Published: March 2023

AbstractPhosphorescence optical waveguides, flexible ones in particular, are fascinating on account of their fundamental and practical values in photonics and optoelectronics devices. However, the majority of optical waveguides reported so far are fluorescent waveguides, the phosphorescent waveguides, especially ones with both flexibility and stimulus‐response are rarely studied. Herein, one‐dimensional phosphorescent microfibers are developed by employing the flexible polymer as the matrix and the phosphorescent emitter as the transducer for out‐coupled light, and their phosphorescent waveguide attributes are studied in detail. Significantly, benefiting from the non‐covalent clipping of molecular tweezer for Pt(II) triplet emitter, the strong and robust tip emission could be obtained for phosphorescent waveguiding microfiber. Furthermore, the asymmetric propagation of phosphorescent waveguide could be achieved via partly acid treatment, since acid could trigger the guest release accompanied by the emission decline. More interestingly, the phosphorescent microfiber exhibits flexible optical waveguide feature and reversible switching of tip emission. Based on the above, Boolean logic operation is selected to demonstrate the application of tunable tip emission. This study establishes an effective and convenient strategy to realize flexible phosphorescent waveguide with tunable tip emission, which is of fundamental value for designing optical functional elements and manufacturing intelligent flexible photonic devices with promising application potential.
Variability modeling and mapping of soil properties for improved management in Ethiopia
Authors: Tiruneh Gizachew Ayalew , Alemayehu Tiringo Yilak , Meshesha Derege Tsegaye , Adgo Enyew , Tiruneh Gebrehiwot Ayalew , Reichert José Miguel 
Published: March 2023

AbstractManaging soils for improved agricultural production requires information on soil fertility status. Our objective was to map for better soil management in Ethiopia and determine their spatial correlation at a separation distance of 29 m. We collected 82 soil samples (0–20 cm depth) at 560 ha of land and determined pH, Olsen extractable phosphorus (Olsen‐P), and organic carbon (OC). We then interpolated between sample points (ordinary kriging‐OK and distance weighting‐IDW [inverse distance weighting]) to evaluate spatial dependence. Olsen‐P ranged from 2.68–42 mg/kg and exhibited high variability with a coefficient of variation (CV) ≥35%. Conversely, soil pH showed low variability (CV ≤ 15%) and ranging from 4.84 to 6.81. Soil OC content varied from 0.81% to 3.17%. The IDW (R2 = 0.86; RMSE = 0.019) outperformed the OK. The semivariogram results indicate a strong dependence for pH and OC for spherical, exponential, and Gaussian models, while moderately spatially auto correlated for Olsen‐P for all models. The IDW and OK predict the spatial variability of the pH (moderately acidic), Olsen‐P (low), and OC (very low) contents. The soil maps may help to improve soil management alternatives, increase crop productivity, and secure environmental quality.
High‐performance Supercapacitors Enabled by Highly‐porous Date Stone‐derived Activated Carbon and Organic Redox Gel Electrolyte
Authors: Dahiru Shuaibu Abubakar , Saeed Alzahrani Atif , Aziz Md. Abdul 
Published: March 2023

AbstractConstruction of eco‐benign, cost effective, and high‐performance supercapacitors with improved electrolytes and hierarchical porous electrodes is necessary for effective energy storage. In this study, a gel type organic redox electrolyte made of polyvinyl alcohol (PVA)‐H2SO4 and an organic redox molecule, anthraquinone (PVA‐H2SO4‐AQ) was prepared by simple solution casting method, and was used to construct a symmetric supercapacitor (SSC) with a date stone‐derived activated carbon (DSAC) having a high BET surface area (1612 m2/g). The DSAC was synthesized by simple carbonization method followed by activation with potassium hydroxide. The SSC exhibit a high specific capacitance of 126.5 F/g at 0.5 A/g, as well as a high energy density of 17.5 Wh/kg at a power density of 250 W/kg with high capacitance retention (87%) after 1000 GCD cycles. The present research suggests that adding anthraquinone to a PVA‐H2SO4 gel electrolyte improves the performance of the fabricated device significantly as compared to using pristine PVA‐H2SO4 or 1 M H2SO4 electrolytes. The research also presents a promising approach for the development of sustainable and eco‐benign materials for energy storage applications. The use of date stone waste as a precursor material for activated carbon electrodes presents an opportunity for cost‐effective and sustainable energy storage. Overall, the findings of this research have important implications for the future design and fabrication of high‐performance and cost‐effective supercapacitors.
Projections of costs and quality adjusted life years lost due to dementia from 2020 to 2050: A population‐based microsimulation study
Authors: Brück Chiara C. , Wolters Frank J. , Ikram Mohammad Arfan , de Kok Inge M. C. M. 
Published: March 2023

AbstractIntroductionEfficient healthcare planning requires reliable projections of the future increase in costs and quality‐adjusted life years (QALYs) lost due to dementia.MethodsWe used the microsimulation model MISCAN‐Dementia to simulate life histories and dementia occurrence using population‐based Rotterdam Study data and nationwide birth cohort demographics. We estimated costs and QALYs lost in the Netherlands from 2020 to 2050, incorporating literature estimates of cost and utility for patients and caregivers by dementia severity and care setting.ResultsSocietal costs and QALYs lost due to dementia are estimated to double between 2020 and 2050. Costs are incurred predominantly through institutional (34%), formal home (31%), and informal home care (20%). Lost QALYs are mostly due to shortened life expectancy (67%) and, to a lesser extent, quality of life with severe dementia (14%).DiscussionTo limit healthcare costs and quality of life losses due to dementia, interventions are needed that slow symptom progression and reduce care dependency.
Epitope Imprinting of Phospholipids by Oriented Assembly at the Oil/Water Interface for the Selective Recognition of Plasma Membranes
Authors: Zhou Juntao , Cheng Xianhui , Guo Zhanchen , Ali Muhammad Mujahid , Zhang Guiyuan , Tao W. Andy , Hu Lianghai , Liu Zhen 
Published: March 2023

AbstractPhospholipids, as fundamental building blocks of the cell membrane, play important roles for molecule transportation, cell recognition, etc. However, due to the structural diversity and amphipathic nature, there are few methods for the specific recognition of lipids as compared to other biomolecules such as proteins and glycans. Herein, we developed a molecular imprinting strategy for controllable imprinting toward the polar head of phospholipid exposed on the surface of cellular membranes for recognition. Phosphatidylserine, as unique lipid on the outer membrane leaflet of exosome and also hallmark for cell apoptosis, was imprinted with the developed method. The phosphatidylserine imprinted materials showed high efficiency and specific targeting capability not only for apoptotic cell imaging but also for the isolation of exosomes. Collectively, the synthesized molecularly imprinted materials have great potential for selective plasma membrane recognition for targeted drug delivery and biomarker discovery.
One‐Step Calcination Synthesis of Bulk‐Doped Surface‐Modified Ni‐Rich Cathodes with Superlattice for Long‐Cycling Li‐Ion Batteries
Authors: Sun Yongjiang , Wang Changhong , Huang Wenjin , Zhao Genfu , Duan Lingyan , Liu Qing , Wang Shimin , Fraser Adam , Guo Hong , Sun Xueliang 
Published: March 2023

AbstractNickel‐rich (Ni≥90 %) layered cathodes are critical materials for achieving higher‐energy‐density and lower‐cost next‐generation Li‐ion batteries (LIBs). However, their bulk and interface structural instabilities significantly impair their electrochemical performance, thus hindering their widespread adoption in commercial LIBs. Exploiting Ti and Mo diffusion chemistry, we report one‐step calcination to synthesize bulk‐to‐surface modified LiNi0.9Co0.09Mo0.01O2 (NCMo90) featuring a 5 nm Li2TiO3 coating on the surface, a Mo‐rich Li+/Ni2+ superlattice at the sub‐surface, and Ti‐doping in the bulk. Such a multi‐functional structure effectively maintains its structural integrity upon cycling. As a result, such NCMo90 exhibits a high initial capacity of 221 mAh g−1 at 0.1 C, excellent rate performance (184 mAh g−1 at 5 C), and high capacity retention of 94.0 % after 500 cycles. This work opens a new avenue to developing industry‐applicable Ni‐rich cathodes for next‐generation LIBs.
Katalysatorkontrolle über dreifache Stereogenität: Selektive Synthese atropisomerer Sulfone mit stereogenen C−S‐Achsen
Authors: Schmidt Tanno A. , Schumann Stephan , Ostertag Andreas , Sparr Christof 
Published: March 2023

AbstractKatalysatorkontrolle über Stereogenität höherer Ordnung vergrößert den zugänglichen stereochemischen Raum erheblich, aber Methoden zur stereoselektiven Synthese dreifach stereogener Einheiten wurden bisher nicht beschrieben. In diesem Artikel berichten wir über die stereokontrollierte Synthese von dreifach stereogenen Triptycylsulfonen, deren Atropisomerie aus einer C(sp3)−S‐Bindung resultiert. Die katalysatorkontrollierte Oxidation eines stereodynamischen Thioethers in Gegenwart einer chiralen Phosphorsäure erlaubte dabei den selektiven Zugang zu enantiomerenangereicherten Triptycylsulfoxiden. Deren anschließende enantiospezifische und diastereoselektive katalytische Oxidation zu einem dreifach stereogenen Sulfon ermöglichte es so, die stereogene C−S‐Achse zu kontrollieren. Alle drei Stereoisomere wurden mit Enantio‐ und Diastereodivergenz und einer Stereoselektivität von bis zu (−sc) : (+sc) : (ap)=94 : 6 : <1 erhalten.
Acid‐Resistant BODIPY Amino Acids for Peptide‐Based Fluorescence Imaging of GPR54 Receptors in Pancreatic Islets
Authors: Mendive‐Tapia Lorena , Miret‐Casals Laia , Barth Nicole D. , Wang Jinling , de Bray Anne , Beltramo Massimiliano , Robert Vincent , Ampe Christophe , Hodson David J. , Madder Annemieke , Vendrell Marc 
Published: March 2023

AbstractThe G protein‐coupled kisspeptin receptor (GPR54 or KISS1R) is an important mediator in reproduction, metabolism and cancer biology; however, there are limited fluorescent probes or antibodies for direct imaging of these receptors in cells and intact tissues, which can help to interrogate their multiple biological roles. Herein, we describe the rational design and characterization of a new acid‐resistant BODIPY‐based amino acid (Trp‐BODIPY PLUS), and its implementation for solid‐phase synthesis of fluorescent bioactive peptides. Trp‐BODIPY PLUS retains the binding capabilities of both short linear and cyclic peptides and displays notable turn‐on fluorescence emission upon target binding for wash‐free imaging. Finally, we employed Trp‐BODIPY PLUS to prepare some of the first fluorogenic kisspeptin‐based probes and visualized the expression and localization of GPR54 receptors in human cells and in whole mouse pancreatic islets by fluorescence imaging.
Suppressing Universal Cathode Crossover in High‐Energy Lithium Metal Batteries via a Versatile Interlayer Design**
Authors: Xie Chuyi , Zhao Chen , Jeong Heonjae , Li Tianyi , Li Luxi , Xu Wenqian , Yang Zhenzhen , Lin Cong , Liu Qiang , Cheng Lei , Huang Xingkang , Xu Gui‐Liang , Amine Khalil , Chen Guohua 
Published: March 2023

AbstractThe universal cathode crossover such as chemical and oxygen has been significantly overlooked in lithium metal batteries using high‐energy cathodes which leads to severe capacity degradation and raises serious safety concerns. Herein, a versatile and thin (≈25 μm) interlayer composed of multifunctional active sites was developed to simultaneously regulate the Li deposition process and suppress the cathode crossover. The as‐induced dual‐gradient solid‐electrolyte interphase combined with abundant lithiophilic sites enable stable Li stripping/plating process even under high current density of 10 mA cm−2. Moreover, X‐ray photoelectron spectroscopy and synchrotron X‐ray experiments revealed that N‐rich framework and CoZn dual active sites can effectively mitigate the undesired cathode crossover, hence significantly minimizing Li corrosion. Therefore, assembled lithium metal cells using various high‐energy cathode materials including LiNi0.7Mn0.2Co0.1O2, Li1.2Co0.1Mn0.55Ni0.15O2, and sulfur demonstrate significantly improved cycling stability with high cathode loading.
Comparative Efficacy of Secukinumab Versus Tumor Necrosis Factor Inhibitors for the Treatment of Takayasu Arteritis
Authors: Tian Xinping , Li Mengtao , Jiang Nan , Zhao Yang , Li Jing , Zhou Yangzhong , Wang Yahong , Wang Ying , Li Taotao , Yang Yunjiao , Wang Yanhong , Merkel Peter A. , Zeng Xiaofeng 
Published: March 2023

ObjectiveTumor necrosis factor (TNF) alpha and interleukin‐17 (IL‐17) are thought to be involved in the pathogenesis of Takayasu arteritis (TAK), and TNF inhibitors (TNFi) are recommended for the treatment of TAK. The present study was undertaken to investigate the efficacy of secukinumab, an IL‐17A monoclonal antibody, compared to treatment with TNFi.MethodsThis was a prospective, single‐center, open‐label cohort study. Patients with active TAK who did not respond to treatment with glucocorticoids combined with 2 immunosuppressive agents were treated with either secukinumab or TNFi as an add‐on therapy without an increased dosage of glucocorticoids. A complete response was defined as complete resolution of signs and symptoms of active disease, normal values of inflammatory markers, no progression on imaging of involved arteries, and dose of glucocorticoid <15 mg/day. A partial response was similarly defined as a complete response except with an erythrocyte sedimentation rate <40 mm/hour and C‐reactive protein level of <20 mg/liter.ResultsNineteen patients in the secukinumab group and 34 patients in the TNFi group were enrolled. The demographic data and inflammatory markers of the 2 groups were comparable at baseline. Complete response and partial response for patients treated with secukinumab and TNFi were 31.6% and 58.8% (P = 0.057), respectively, at 3 months and 52.6% and 64.7%, respectively, at 6 months (P = 0.389).ConclusionOur findings suggest that secukinumab and TNFi are effective for patients with TAK who do not respond to oral glucocorticoids and conventional immunosuppressive agents, with similar response rates at 3 and 6 months.
image
Photometry and astrometry with JWST‐II: NIRCam distortion correction
Authors: Griggio M. , Nardiello D. , Bedin L. R. 
Published: March 2023

AbstractIn preparation to make the most of our own planned James Webb Space Telescope investigations, we take advantage of publicly available calibration and early‐science observations to independently derive and test a geometric‐distortion solution for NIRCam detectors. Our solution is able to correct the distortion to better than 0.2 mas. Current data indicate that the solution is stable and constant over the investigated filters, temporal coverage, and even over the available filter combinations. We successfully tested our geometric‐distortion solution in three cases: (i) field‐object decontamination of M 92 field; (ii) estimate of internal proper motions of M 92; and (iii) measurement of the internal proper motions of the Large Magellanic Cloud system. To our knowledge, the here‐derived geometric‐distortion solution for NIRCam is the best available and we publicly release it, as many other investigations could potentially benefit from it. Along with our geometric‐distortion solution, we also release a Python tool to convert the raw‐pixels coordinates of each detector into distortion‐free positions, and also to put all the ten detectors of NIRCam into a common reference system.
Muscle stem cells get a new look: Dynamic cellular projections as sensors of the stem cell niche
Authors: Krauss Robert S. , Kann Allison P. 
Published: March 2023

AbstractCellular mechanisms whereby quiescent stem cells sense tissue injury and transition to an activated state are largely unknown. Quiescent skeletal muscle stem cells (MuSCs, also called satellite cells) have elaborate, heterogeneous projections that rapidly retract in response to muscle injury. They may therefore act as direct sensors of their niche environment. Retraction is driven by a Rac‐to‐Rho GTPase activity switch that promotes downstream MuSC activation events. These and other observations lead to several hypotheses: (1) projections are morphologically dynamic at quiescence, providing a surveillance function for muscle damage; (2) quiescent projection dynamics are regulated by the relative balance of Rac and Rho activities promoted by niche‐derived cues; (3) projections, particularly their associated filopodia, sense tissue damage via changes to the biomechanical properties of the niche and/or detection of signaling cues released by damaged myofibers; and (4) the dynamic nature of projections results in a population of MuSCs with heterogeneous functional properties. These concepts may extend to other types of quiescent stem cells, as well as prove useful in translational research settings.