bluuebunny/crossref_metadata_2025_split huggingface dataset:
PS-C30-4: ASSOCIATION OF ASSISTED REPRODUCTIVE TECHNOLOGIES WITH ARTERIAL HYPERTENSION DURING NEWBORN
Authors: Furusawa Yuri , Iwashima Satoru , Uchiyama Hiroki , Ishikawa Takamichi 
Published: January 2023

In Japan, infertility treatment including assisted reproductive technologies < ART> has become common recently, accounting for 7% of ART newborns in all births. Recently, ART has been reported to induce premature vascular aging in apparently healthy children. It is unknown whether the onset of premature vascular aging begins in the newborn period. Our study was to determine whether an increased risk of premature vascular aging is associated with ART.
The study population comprised 63 newborns < median gestational age<GA> 39 weeks, and median birth weight <BW> 3050g>in the assisted conception <AC> group and 279 newborns <GA 39 weeks, BW 3030g> in the spontaneous conception <SC> group. The AC group was treated as follows: 29 patients with in vitro fertilization, or with intracytoplasmic sperm injection with ovulation-inducing agents <ART group>, 34 with artificial insemination, and others. After confirming the closing of the patent ductus artery using echocardiography, newborns measured their peripheral systolic <sys> and diastolic <dia> blood pressure <BP> values. BP measurements of newborns were performed in the left or right legs in the relaxed supine position with basically a natural sedation. At the median age of one day after birth, comparing sys and dia BP with AC and SC group, sys BP 69 and 40mmHg vs 68 and 41mmHg, there were no significant. Similarly, in the ART group, sys and dia BP was 68 and 40mmHg, with no significant differences. However, there were significant differences between maternal age, SC, AC, and ART groups, with the median of 31years, 35years, and 37years <p value less than 0.001>.
We found no evidence of increased risk of premature vascular aging with ART for infertility treatment during the newborn period. Older maternity may alter affect childhood health and development. In addition, in vitro or extrauterine fertilization exposes gamete and embryo to variable physical and hormonal environments before implantation. Exposure is brief in fresh fertilizations and more prolonged in a gamete or embryo cryopreservation, and such epigenetic modifications of the environment may have downstream effects on the vascular system. The future of precision medicine guided approaches should incorporate emerging clinical factors, such as the history of ART conception in a growing proportion of the population.
PS-C30-7: THE ASSOCIATION BETWEEN INSULIN RESISTANCE AND DECLINE IN ORGAN FUNCTION IN NON-OBESE JAPANESE INDIVIDUALS
Authors: Kaneko Kenji , Hirota Ryoko Shimizu , Makino Kanako , Nagasaka Tomoaki , Kojima Daiki , Takaishi Hiromasa , Yoshino Jun , Itoh Hiroshi 
Published: January 2023

Background:
Obesity-induced insulin resistance is a critical metabolic abnormality involved in the decline in various organ functions, which likely contributes to the development of serious diseases, such as type 2 diabetes, hypertension, and cardiovascular disease. However, little information is available on the association between insulin resistance and organ function in non-obese people. The major purpose of this study was to investigate the relationship between insulin resistance (estimated by the homeostasis model assessment for insulin resistance, HOMA-IR) and selected indicators of organ-specific functions in non-obese individuals.

Materials and Methods:
We analyzed data obtained from non-obese (body mass index [BMI], 18.5 to < 25 kg/m2), non-diabetic 3546 Japanese individuals (2034 men and 1512 women) who received health checkups in 2018 at Keio University Hospital. Individuals were divided into quartiles according to their HOMA-IR values. Multiple regression analysis was performed to further investigate the relationship between HOMA-IR values and organ parameters after adjustment for covariates, such as age, gender, and BMI.

Results:
Those with HOMA-IR in the highest quartile had a higher incidence of metabolic syndrome, hypertension, stroke, and chronic kidney disease. There were significant stepwise (P < 0.05) increases in metabolic syndrome indicators (BMI, visceral adipose tissue area, triglyceride, uric acid), liver enzymes (AST, ALT, γGTP, ChE), systemic inflammatory markers (white blood cell count, CRP), systolic and diastolic blood pressure, and ocular pressure, from the first quartile to fourth quartile of HOMA-IR, whereas there were stepwise decreases in HDL-C and parameters of renal function (eGFR) and pulmonary function (forced expiratory volume, vital capacity). Multiple regression analyses revealed that HOMA-IR values were significantly (P < 0.05) associated with these parameters expect eGFR even after adjusting for covariates.

Conclusion:
Our results suggest that insulin resistance is associated with decline in the function of multiple organs in non-obese, non-diabetic Japanese individuals. Further studies are required to establish cause and effect in this relationship.
PS-C30-13: GESTATIONAL HYPERTENSION AND PERIPARTUM CARDIOMYOPATHY: EPIDEMIOLOGICAL, CLINICAL AND EVOLUTIONARY PROFILE IN THE REFERENCE HOSPITALS OF YAOUNDE
Authors: Christian Ngongang Ouankou , Paturelle Jonte Mbianda Klod , Liliane Mfeukeu Kuate , Raoul Simeni Njonnou Sylvain , Ariane Owona Ngandebe Amalia , Raspail Founou Zangue Carrel , Debozard Ouankou Merimee , Patrick Menanga Alain 
Published: January 2023

Background:
Peripartum cardiomyopathy (PPCM) is a primary dilated cardiomyopathy responsible for congestive heart failure that occurs in the last two months of pregnancy or during the first five months of postpartum. It is a rare pathology with unknown etiologies. Nevertheless, several etiopathogenic factors such as an history of gestational hypertension, black race, multiparity and poverty have been incriminated. However, the epidemiological and clinical data on peripartum cardiomyopathy are little known in Cameroon, thus justifying our descriptive study.

Methodology:
We carried out a prospective descriptive study over a period of six months. It was conducted in six reference hospitals in Yaounde. The study population was made of pregnant women with dyspnoea and women who had given birth with dyspnoea. Were included all pregnant or postpartum women (from the 32nd WA to the 5th months of postpartum) who had a LVEF < 45% and/or a SF < 30% associated or not with left ventricle dilation. They were placed on treatment with a follow-up over 3 months, where they had a second cardiac ultrasound to highlight the evolutionary profile.

Results:
We enrolled 10 patients from 26 women who were pregnant or had given birth and presented with dyspnoea within 6 months. The average age was 25.9 ± 4.9 years (range: 16–33 years). The average parity was 1.6 ± 1.17 (extreme 0–3). Multiparas were the most represented. The history of gestational hypertension was the main predisposing factor found (50%); followed by multiparity (30%), the notion of twin pregnancy and advanced maternal age (20%). Heart failure was the clinical expression in 60% of cases. Sinus tachycardia was constant; followed by signs of left ventricular hypertrophy and repolarization disorders on ECG assessment. The echocardiographic pattern depicted a hypokinetic dilated cardiomyopathy (mean LVEDD 61.2 ± 8.6 mm) with an average systolic function of 27.1 ± 10.6%. The main complications were acute pulmonary edema (60%), thromboembolic events including pulmonary embolism (10%), ischemic stroke (10%) and one death (10%). The treatment mostly based on the use of diuretics, ACE inhibitors, beta-blockers, Aldactone (1/3 of the patients) without forgetting the anticoagulation made with Rivaroxaban(n = 4) for some and aspirin (n = 6); and bromocriptine (initiated in 3 patients).

Conclusion:
PPCM is a cause of heart failure during pregnancy. It primarily arises during the postpartum period regardless of maternal age. It is a serious disease due to its (important morbi-mortality rate) and its complications, both hemodynamic and thromboembolic.\
PS-C30-14: A CASE OF PREECLAMPSIA DIAGNOSED BY RENAL BIOPSY
Authors: Koshida Takeo , Suzuki Hitoshi , Iwasaki Masako , Umezawa Yukako , Yoshida Maiko , Hamaguchi Sho , Fukuda Hiromitsu , Takahara Hisatsugu , Tomita Shigeki , Suzuki Yusuke 
Published: January 2023

Preeclampsia is a complicat ion of pregnancy. With preeclampsia, the patients show high blood pressure and high levels of proteinuria. Preeclampsia usually begins after 20 weeks of pregnancy in women whose blood pressure had previously been in the standard range. If the patients left untreated, preeclampsia can lead to serious complications for both the mother and baby. Meanwhile, focal segmental glomerulosclerosis (FSGS) is also need to be discriminated in pregnant women with massive proteinuria.
A 32-year-old woman has not been recognized hypertension, and has never been pointed out any urinary abnormality in a medical checkup. Her blood pressure gradually increased at 30 weeks of gestation. At 34 weeks gestation, blood pressure was 180/108 mmHg with medication, and she was detected proteinuria. Even after delivery, massive proteinuria (13.7 mg/gCr) was detected without microscopic hematuria. Then, renal biopsy was performed for definitive diagnosis. Histological findings showed focal endotheliosis of the glomeruli and double contour in which are the typical histological findings for preeclampsia.
High levels of proteinuria after delivery is important index for medical treatment. Present case was diagnosed as preeclampsia by renal biopsy resulted in keep antihypertensive treatment without any immunosuppressant. The histological implication on our clinical management of preeclampsia may be profound for understanding of strict control of blood pressure during perinatal period.
PS-C31-8: UNCONTROLLED HYPERTENSION AND ITS ASSOCIATED FACTORS AT PRIMARY HEALTH CARE FACILITIES IN MAPUTO CITY, MOZAMBIQUE
Authors: Tualufo Sheila Uamba , Tembe Esselina , Jessen Neusa , Govo Velario , Lunet Nuno , Damasceno Albertino Moura 
Published: January 2023

Objective:
the main objective of this study was to estimate the prevalence of uncontrolled hypertension in patients being followed up at primary health care facilities of Maputo City, and to identify factors associated to poor blood pressure control.

Design and Methods:
a cross-sectional study was conducted from September to December 2021 in nine primary health care facilities randomly selected in Maputo City. Five hundred consecutive hypertensive patients aged 18 years or older, on medical therapy and being followed up for more than six months who consented to participate were enrolled. Data was collected through face-to-face interviews, review of medical records and anthropometric and blood pressure measurements to the participants. Three blood pressure measurements were taken in the same arm, with two minutes of interval. The mean of the last two readings was considered for analysis. Uncontrolled hypertension was defined as blood pressure ≧ 140/90 mmHg. Therapeutic inertia was defined as non-increase in antihypertensive therapy after two or more follow-up consultations in patients with a blood pressure ≧ 140/90 mmHg. Hill Bone scale was used to assess adherence to antihypertensive therapy. Data analysis was performed using SPSS 22. Logistic regression was performed to estimate age- and education-adjusted Odds Ratios (OR) and 95% confidence intervals (95%CI) for uncontrolled hypertension. A p-value less than 0.05 was considered significant.

Results:
among the 500 participants, 385 (77%) were female, the mean age was 59.7 years [standard deviation (SD) ± 10.4] and the mean duration of hypertension was 8.9 years (SD ± 8.2). Most participants had primary education 300 (60%).
The prevalence of uncontrolled hypertension was 73.2%. It was more common in patients 60 years or older compared to younger patients (adjusted OR 2.42; 95%CI: 1.30–4.52); among patients without formal education compared to those with higher levels (adjusted OR 0.45, 95%CI: 0.22–0.92, for secondary or higher education); in patients that referred difficulties in having access to the antihypertensive medication (adjusted OR 1.76, 95%CI 1.16 -2.69) and when therapeutic inertia was found (adjusted OR 2.53, 95%CI 1.10–5.86).

Conclusions:
uncontrolled hypertension is an important problem in primary health care in Maputo City and is associated to advanced age, lower levels of education, difficulty to access anti-hypertensive medication and therapeutic inertia. Training of health professionals and greater availability of anti-hypertensive medication in primary health care centers could improve blood pressure control.
PS-C33-3: THE EFFECT OF AGE AND HYPERTENSION ON PODOMETRICS IN DIFFERENT CORTICAL ZONES OF THE HUMAN KIDNEY
Authors: Haruhara Kotaro , Kanzaki Go , Sasaki Takaya , Hatanaka Saeko , Okabayashi Yusuke , Shimizu Akira , Tsuboi Nobuo , Yokoo Takashi 
Published: January 2023

Objective:
Podocyte loss and resultant nephron loss are common processes in the progression of glomerulosclerosis and CKD. Aging and hypertension are the main causes of benign nephrosclerosis, which is histologically characterized by concomitant appearances of glomerular collapse and enlargement. Glomerular hypertrophy and glomerulosclerosis often preferentially occur in specific cortical zones of the kidney, possibly due to the difference in kidney artery perfusion. However, it is unknown if podometrics, such as podocyte number per glomerulus, podocyte density and podocyte volume, differ among different cortical zones in the human kidneys. The aim of the present study is to determine the effect of aging and hypertension on podometrics in different cortical zones of the human kidneys.

Design and method:
Autopsy kidneys from 50 Japanese adults without apparent glomerular disease were cross-sectionally analyzed. Podometrics in different cortical zones (superficial/middle/juxtamedullary) were estimated on a single section using a model-based stereology.

Results:
Median age was 68 years and median eGFR was 73.5 mL/min/1.73m2. Hypertension was identified in 21 (42%) subjects. While podocyte number per glomerulus was similar in the three zones, superficial glomeruli were the smallest and had the highest podocyte density and smallest podocytes. Increasing age and hypertension were associated with lower podocyte number, with age mostly affecting superficial glomeruli, and hypertension mostly affecting juxtamedullary glomeruli. There was no significant interaction between age and hypertension (Figure). Neither podocyte density, podocyte volume nor volume density of podocytes in glomeruli was associated with age or hypertension.

Conclusions:
Podometric changes, especially decreased podocyte number per glomerulus, may also contribute to the development and different distribution of glomerular morphological phenotypes in aging and hypertension-related benign nephrosclerosis.
PS-C33-7: TRUE RESISTANT HYPERTENSION IN A TERTIARY HYPERTENSION CLINIC IN SAUDI ARABIA
Authors: Mahmud Azra , Alahaideb Ruba , Alhabdan Nawaf Abdul Aziz , Alkhdri Mohammad Hamad 
Published: January 2023

Objective:
Resistant hypertension(RH), defined as office blood pressure (BP) above goal despite the use of more than three anti-hypertensives (one ideally being a diuretic) or BP that requires more than four agents to achieve control, has received more attention with increased efforts to improve BP control rates and the emergence of device-based therapies. Based on this definition of RH, the prevalence rates vary around 15–30% worldwide. However, there is paucity of data on RH, particularly true RH in the Middle-East.
The aim of this study was to explore the prevalence, clinical characteristics and choice of anti-hypertensives in a Saudi RH population.

Design & Methods:
We analysed retrospectively clinic and ambulatory BP monitory (ABPM) data in Saudi patients between January 2016 to June 2018. Office HTN was defined as greater than 140 systolic or greater than 90 diastolic, mm Hg. HTN was confirmed using one of the following ABPM cut-offs; 24-hr greater than 130/80 or daytime greater than 135/85, mm Hg. Results were analysed using JMP version 13, p less than 0.05 considered significant.

Results:
The mean age of the population(n = 540) was 54 ± 15 years, 40% female. The overall prevalence of RH was 47% in our cohort, of which 35% was true RH. The patients with RH were older; 62 ± 13 vs. 50.5 ± 14 years with no significant gender difference. RH was associated with diabetes (OR = 6.2, CI%, 3–12); CAD(OR = 3.3, CI%, 2–5); history of coronary revascularization(CABG/PCI) (OR = 3, CI%, 2–5); CKD(OR = 5.7, CI%, 3–12) and heart failure(OR = 1.9, CI%, 1–3). The average number of anti-hypertensives was 4.2 ± 1 in RH compared with 1.1 ± 1 in control group. Only a third of the patients were prescribed spironolactone in the RH group with some 10% on an alpha blocker.

Conclusions:
To the best of our knowledge, this is the first study in the Middle-East to establish the prevalence of true RH using ABPM. With a high prevalence rate, our cohort of RH is complex with high number of co-morbidities, sub optimal prescription rates of spironolactone or alpha-blockers, representing a therapeutic challenge.
PS-C34-13: LATE NIGHT EATING OR CIRCADIAN DISRUPTION COULD BE MORE DANGEROUS THAN OUR THINK FOR PATIENTS OF DIABETES WITH HYPERTENSION
Authors: Naz Qulsoom , Siddiqui Kauser Usman , Verma Narsingh , Mahdi Abbas Ali , Anjum Baby 
Published: January 2023

Background:
Our bodies function optimally when we align our eating & sleeping patterns with our circadian rhythms, the innate 24-hour cycles that tell our bodies when to wake up, when to eat and when to fall asleep. Chronically disrupting this rhythm by eating late night meals & sleep could be a recipe for Hypertension, CVD, and metabolic trouble.

Aim & Objective:
The aim of this study is to investigate whether there was a relationship between morningness(MC) (110n) intermediate(IC) (100n) & eveningness chronotype(EC) (35n) in T2DM.

Methods:
A total of 245 subjects age 18 to 60 years were recruited in Clinical OPD of General Medicine, KGMU. We have tested FBG & PP level, lipid profile HbA1c, Insulin, Leptin and Cortisol level, 48 hours ABPM.

Result:
When we compared these 3 groups, Significant Different parameters found in FBG (P = 0.01) Postprandial (P = 0.03) HbA1c (P = 0.001) TG (P = 0.0001), Total Cholesterol (P = 0.01) & VLDL (P = 0.005). It also shows the complete inversion of the cortisol level (0.003). Insulin, IL-1 beta & IL-6 also show significant change in late night eating T2DM Patients. Systolic / Diastolic readings of ABPM shows significant change between MC and IC (0.005) but not b/w EC & IC (0.007). And for reliability of sleep by actigraphy shows MC (6:15 + 1:35) & EC (8:18 + 1:23) take complete sleep but IC total sleep hours (5:10 + 1:05) are very less. Disruption of Rev Erb & Ror alpha gene expression is also a risk factor for Cardio metabolic Diseases in T2DM Patients.

Conclusion:
Eveniningness & Intermediate Type Patients are more likely to have late night eaters & are associated with greater risk of Metabolic Disorders like Blood Pressure Variability, Dyslipidemia, T2DM & CVD.
PS-C35-3: EFFECT OF BMI REDUCTION ON BLOOD PRESSURE CHANGES IN OVERWEIGHT PATIENT: A SYSTEMATIC REVIEW AND META-ANALYSIS
Authors: Yang Shijie , Zhou Zhanyang , Miao Huanhuan , Zhang Yuqing 
Published: January 2023

Objective:
To determine quantitative differences between weight loss and changes in clinic blood pressure (BP) in overweight patient, a systematic review and meta-analysis of randomised trials was performed.

Design and method:
A systematic literature search was conducted to identify relevant studies in the PubMed, Embase and Scopus databases up to April 2022. Only studies with English language were included. Studies were considered for inclusion if they met the following criteria: (1) included comparison clinical BP between weight loss; (2) the mean values and standard deviations (SD) of clinical BP and BMI were reported respectively; (3)all patients have a BMI ≧ 25 kg/m2. The certainty of evidence was used the GRADE approach. All statistical analyses were performed using Revman 5.

Results:
Twenty-four studies, for a total of 2614 patients were included in this meta-analysis. The clinic systolic blood pressure (SBP) and diastolic blood pressure (DBP) were significantly reduced by 7.04 mmHg (95% CI, 5.04–9.03) and 4.40 mmHg (95% CI, 3.17–5.62) after a mean body mass index (BMI) reduction of 2.42 Kg/m2. The BP reductions were much larger in patients with a BMI decrease ≧ 3 kg/m2 than in patient with less BMI decrease, both for SBP [10.32 mmHg (95% CI, 6.15–14.49)] vs. [5.79 mmHg (95% CI, 3.19–8.39)] and DBP [7.48 mmHg (95% CI, 4.50–10.47)] vs [3.93 mmHg (95% CI, 2.15–5.70)]. The BP reductions were also much larger in patients with a baseline BMI ≧ 30 kg/m2 than in patients with a lower BMI, both for SBP [8.90 mmHg (95% CI, 5.97–11.83) vs. 5.25 mmHg (95% CI, 2.19–8.31)] and DBP [6.02 mmHg (95% CI, 3.89–8.14) vs. 3.82 mmHg (95% CI, 1.78–5.86)]. Furthermore, the SBP and DBP reductions in patients with medical interventions (ie drugs and surgeries) were 9.22 mmHg (95% CI, 6.36–12.08) and 6.11 mmHg (95% CI, 3.29–8.92) respectively, which were larger than patients with lifestyle interventions both for SBP [4.69 mmHg (95% CI, 2.81–6.57)] and DBP [3.82 mmHg (95% CI, 2.22–5.43)].

Conclusions:
The significant reduction of clinic BP followed the weight loss, and this phenomenon could be more notable after medical intervention and a larger weight loss.
PS-C35-7: THE TIME TREND OF INFORMATION SEEKING BEHAVIOR ABOUT SALT REDUCTION IN JAPAN
Authors: Suzuki Takahiro , Mizuno Atsushi 
Published: January 2023

Objective:
When considering hypertension management, salt reduction is the most important lifestyle modification for cardiovascular prevention, especially in Japanese who still consume a significant amount of salt. For achieving a goal for salt reduction, the Japanese Society of Hypertension collaborated with stakeholders including business sectors and the government. However, the public awareness and interest about salt reduction has not been fully evaluated. In this study, by using Google trend, we retrospectively evaluated time trend of information seeking behavior about salt reduction in Japan.

Design and method:
We searched Google Trends for search terms relating to salt reduction. First, we searched “salt reduction” and filtered the top seven related searches to obtain relative search volumes (RSVs) for the period January 1, 2004, to December 31, 2021, in Japan. Correlation coefficient and regression coefficient were estimated to evaluate the time trend of seeking behavior about salt reduction. The contribution of related searches to the main search for “salt reduction” are also calculated in each month to evaluate the seasonal peak of the contribution to the “salt reduction”.

Results:
Both RSVs for salt reduction with ant without filtering top seven related searches significantly increased from 2004 to 2021 (13.8 ± 9.3 to 70.8 ± 10.9, r = 0.92, p-value < 0.001 and 8 ± 7.1 to 49.2 ± 3.5, r = 0.93, p-value < 0.01, respectively). Regression coefficients indicated that RSVs increased 0.0091 (95% CI, 0.0085–0.0097, p < 0.001) per year for salt reduction and 0.0065 (95% CI, 0.0061–0.0069, p < 0.001) per year for salt reduction filtered related searches (Figure A). Among related search results, search for “salt component”, “soy sauce” and “soy sauce” contributed to 9.9 ± 3.2%, 5.8 ± 2.0%, and 3.9 ± 5.5% of total RSVs for salt reduction. Of note, pickled plum explained all RSV for salt reduction in 18.0 ± 9.2% in June, which peaked in 41% in 2021 (Figure B).

Conclusion:
RSVs from Google trends apparently indicated increasing pattern of information seeking behaviors for salt reduction. Related searches might provide us insights when people search for salt reduction, which could be useful for future effective interventions for awareness of salt reduction.