bluuebunny/crossref_metadata_2025_split huggingface dataset:
Establishing the role of shear wave elastography in differentiating corporal rigidity between vasculogenic versus non-vasculogenic erectile dysfunction patients: a novel diagnostic modality
Authors: Singh Pushpendra , Sharma Aditya Prakash , Chowhan Prabhjyot Singh , Gorsi Ujjwal , mavuduru Ravimohan , lal Anupam , Mete uttam K 
Published: August 2023

Abstract
Background Shear-wave elastography (SWE) is a new modality for evaluation of erectile dysfunction (ED) by assessing the stiffness of tissue. SWE could be an objective tool for assessing penile rigidity during erection and to establish the vascular subtype of ED. In this study we evaluated the SWE values in ED patients in the Indian subpopulation and compare SWE findings between vasculogenic and non-vasculogenic ED patients.Material and Methods 40 patients with clinically diagnosed ED filled out an abridged five-item version of the international index of erectile dysfunction (IIEF-5) questionnaire and underwent SWE as well as pharmacologically induced penile erection (PIPE) test after intracavernosal papaverine injection. SWE values were obtained serially at 5 minutes interval at two locations: Central (cavernosal artery centered circular region) and Peripheral (near the tunica albuginea). SWE values were compared with the ED types based on PIPE test.Results Mean age of patients was 32.48 ± 6.6 years and the median IIEF-5 score was 11(IQR:9–14).IIEF-5 scores had significant inverse correlation with central SWE value in erectile state (p = 0.000, r= -0.536).Median central SWE values were significantly lower in the erectile state as compared to flaccid state in both vascular (8.27 kPa(IQR:6.3–12.5) vs. 23.27 kPa(IQR:15.9–28.6) p = 0.000) and nonvascular(5.50 kPa(IQR:4.4–6.7) vs. 23.85 kPa(IQR:17.8–33.6) p = 0.000) ED patients. Vascular ED patients had significantly higher central SWE value in erectile state than non-vascular ED patients (8.27 KPa (IQR:6.3–12.5) vs. 5.50 KPa (IQR:4.4–6.7) p = 0.001).ROC analysis revealed that the cut off value for central SWE was 5.65 kPa in erectile state with the sensitivity, and specificity for predicting vascular ED being 90.9% and 61.1% respectively. The Area under the curve was 0.816 with a standard error of 0.071 (p = 0.001).Conclusion Central cavernosal shear wave elastography is a good modality to objectively quantify the penile rigidity and can be used to distinguish subtype of erectile dysfunction.
Analysis of Residual Error in Closed Loop Operation of Brushless DC (BLDC) Motor using Novel Neural Network Approach
Authors: Manas Munish , Yadav Ravish , Sharma Shivi , Srivast Abhinav 
Published: August 2023

Abstract
In existing technique for speed regulation of Brushless DC (BLDC) motor, great performance is achieved but only for fixed speed reference, during dynamic change in reference speed the existing techniques fail due to presence of non-linear complex parameter in the system. The proposed novel and simple Multi-Layer Perceptron (MLP) technique is capable of regulating the speed of a BLDC motor, according to dynamically changing reference paths, by minimizing residual error. The MLP, which is a compound of a deep learning artificial neural network, comprises two layers; one which receives speed error data from the traditional PID controller, and another which predicts the output data. Computations are carried out through Gradient Descent for arbitrary hidden layers, in order to reduce the speed error. As the computed output approaches the target, the optimal data for speed regulation is produced. This proposed MLP technique and Advanced Particle Swarm Optimization (APSO) algorithms have been simulated, using ramp, step, and sinusoidal reference speeds under the same platforms.
The effect of an online supportive program on the care burden of parents of children with leukemia
Authors: Sabeghi Hakimeh , Sabzehkar zeinab , Moonaghi Hossein Karimi Moonaghi Karimi , vaghrseyyedin Seyyed Abolfaz , Bagherian Samaneh 
Published: August 2023

Abstract
Purpose:This study aimed to examine the effect of an online supportive program on the care burden of parents of children with leukemia.
Methods: The present study is a quasi-experimental research designed in 2020 on 76 parents of children with leukemia in Mashhad, Iran. The participants in the intervention group attended the supportive program held via WhatsApp messenger for one month(N=38). The participants in the control group received only the hospital routine support(N=38). The collected data were analyzed with SPSS-20 software.
Results: The findings revealed that the mean care burden scores before the intervention did not differ significantly between the two groups (p=0.061). The average parental care burden score in the intervention group before the intervention was 45.63±4.44 which decreased significantly (p<0.015) after the intervention (42.81±5.07). However, the average care burden score before the intervention (43.94±3.17) and after the intervention (45.13±4.50) did not have a statistically significant difference for the participants in the control group. After the completion of the intervention, the care burden decreased significantly in the intervention group compared to the control group (p<0.05).
Conclusions: Regular supportive programs can be developed and implemented for the main caregivers of patients with other chronic diseases and integrated into the health system.
The potential of fungal endophytes isolated from wild rice species for paddy (Oryza sativa L,) health management
Authors: Jena Rupalin , Mukherjee Arup Kumar , Swain Harekrushna , Samanta Soma , Adak Totan 
Published: August 2023

Abstract

Eleven endophytic fungi were isolated and identified from seven wild rice species which were confirmed to be endophytes using endophyte specific marker. Curvularia lunata (NRRI EF-11) and Hypocreals sp (NRRI-EF-8) resulted in better bio control effectivity against 4 different rice pathogens. The same isolate had better growth promotion activities in rice as compared to other isolates. Production of plant growth promoting chemicals namely IAA, IP and prussic acid were studied. Induction of defense was confirmed analyzing the expression of different defense enzymes. interestingly all the endophytes were able to enhance yield. So, these endophytes can be utilized for better management of crop health resulting in higher yield and return.
Clinical concordance evaluation of the causality of sequence variants
Authors: Zhou Peng , He Na , Lin Zhi-Jian , Yan Li-Min , Wang Jie , Bian Wen-Jun , Meng Heng , Shi Yi-Wu , Su Tao , Liu Xiao-Rong , Yi Yong-Hong , Liao Wei-Ping 
Published: August 2023

Abstract
Interpreting the sequence variants is a scientific challenge, as well as realistic task in clinical practice. The pathogenicity of variants depends not only on the damage but also the genetic dependent quantity (GDQ, quantitative genetic function required for normal life) that differs in each gene, but was not considered in previous protocols. We developed a clinical concordance evaluation (CCE) framework to evaluate the pathogenicity/causality of variants by comparing the clinical-genetic feature of a patient with the pathogenic feature of candidate gene, including phenotype specificity, pathogenic genotype, genotype-phenotype (severity) correlation, and inheritance, which are associated with the GDQ. In 337 patients with epilepsy on genetic test, 70 variants were evaluated as pathogenic/likely pathogenic by American College of Medical Genetics and Genomics guideline (ACMG). The CCE identified all these pathogenic/likely pathogenic variants, but excluded the pathogenicity of one variant. The CCE identified additional 13 possible-causative, one likely-causative, and two causative variants, including a causative homozygous variant of MFSD8 associated with ceroid lipofuscinosis, which was evaluated to be uncertain significant by ACMG. The CCE is a framework with individualized criteria on the clinical phenotype of patient and the pathogenic features of individual gene, being potentially a practical protocol for individualized medicine of future.
Prevalence of meeting 24-hour movement guidelines and its associations with health indicators in people with disabilities: A systematic review and meta-analysis
Authors: Huang Jiafu , Li Xuecheng , Li Gen , Haegele Justin A. , Zou Liye , Chen Sitong , Li Chunxiao 
Published: August 2023

Abstract
Background
Meeting the 24-hour movement guidelines (i.e., physical activity, sedentary behavior, sleep) could generate health benefits to people with disabilities. However, no systematic reviews or meta-analyses have examined the prevalence of meeting these guidelines and associations with health indicators in this group. The purpose of this systematic review and meta-analysis was therefore to examine the prevalence of meeting the 24-hour movement guidelines and associations with health indicators among people with disabilities.
Methods
Major databases including PubMed, SPORTDiscus, Web of Science, PsycINFO, Embase, and Scopus were searched for studies published in English from inception to May 31, 2023. Studies reporting on the prevalence of meeting overall 24-hour movement guidelines or each of the 3 guidelines in people with disabilities were included. Meta-analyses with the random-effects model were used to determine the prevalence of meeting overall and individual 24-hour movement guidelines. Qualitative syntheses were employed to describe the associations between meeting the guidelines and health indicators.
Results
Twenty-four cross-sectional studies comprising 77510 participants (41.6% females) with disabilities aged 6–65 years from 8 countries were identified. Overall, 6.97% of the participants with disabilities met all three 24-hour movement guidelines, and 16.65% met none of the guidelines. Children and adolescents with disabilities had significantly lower prevalence of meeting all 3 guidelines (5.10%) than that of adults with disabilities (16.49%; P = 0.006). Participants with sensory impairments had significantly higher overall prevalence (13.89%) than those with neurodevelopmental disorders (4.67%; P = 0.001). The findings of qualitative synthesis generally indicated that people with disabilities who met all 3 guidelines reported better psychosocial health indicators such as social relationship and quality of life (9/9 studies) than those met none or only 1 of the guidelines. There was limited evidence or research for other health indicators (e.g., adiposity).
Conclusion
There is some evidence showing that the prevalence of meeting all three 24-hour movement guidelines in people with disabilities is low, particularly in groups of children and adolescents and neurodevelopmental disorders. Meanwhile, there is preliminary evidence suggesting that meeting all 3 guidelines is associated with better psychosocial health than meeting none of the guidelines. More studies are needed to provide further evidence.
L4-L5 anatomy classification system for lateral lumbar interbody Fusion
Authors: Amaral Rodrigo , Pokorny Gabriel , Alvernia Jorge E. , Pimenta Luiz 
Published: August 2023

Abstract
Introduction: Lateral lumbar interbody fusion (LLIF), developed by Dr. Luiz Pimenta in 2006, allows access to the spinal column through the psoas major muscle. The technique has many advantages, such as reduced bone and muscular tissue damage, indirect decompression, larger implants, and lordosis correction capabilities. However, this technique also has drawbacks, with the most notorious being the risk of spinal pathologies due to indirect injury of the lumbar plexus, but with low rates of persistent injuries. Therefore, several groups have proposed classifications to help identify patients at a greater risk of presenting with neurological deficits. The present work aims to propose a new classification system that relies on the simple observation of easily identifiable key structures to guide lateral L4-L5 LLIF decision-making.
Methods: Patients aged > 18 years who underwent preoperative magnetic resonance imaging (MRI) were included. This came to the office between 2022 and 2023 until 50 quality images were acquired. And excluded as follow Anatomical changes in the vertebral body or major psoas muscles prevent the identification of key structures or poor-quality MRIs. Each anatomy was classified as type I, type II, or type III according to the consensus among the three observers.
Results: Fifty anatomical sites were included in this study. Seventy percent of the L4-L5 anatomy were type I, 18% were type II, and 12% were type III. None of the type 3 L4-L5 anatomies were approached using a lateral technique.
Conclusion: The proposed classification is an easy and simple method for evaluating the feasibility of a lateral approach to–L4-L5.
Atypical presentation of Ramsay Hunt Syndrome (RHS)A case report
Authors: Elamin Abubakr Elmotesim Abdulla , Daoud Mahmoud Hussien Salih , Mohmed Mohmed Hussien Ahmed 
Published: August 2023

Abstract
Background :This case emphasizes the atypical presentation of RHS, in which the rash was
distributed over cervical dermatomes (C3, C4).
Case presentation: A 55-year old Sudanese woman presented with left side mouth deviation and
difficulty in closure of her right eye. Which happened two weeks after the appearance of a vesicular
rash over the right side of her head, ear, down to the right side of her neck as well as submandibular
area, and improved with treatment (acyclovir and prednisolone).
Conclusion: Physicians should be aware of typical and atypical presentations of RHS to facilitate
prompt diagnosis and provide appropriate management. Early intervention with antiviral and
corticosteroid has shown to significantly improve outcomes in these patients.
Legionella detection in wastewater treatment plants with increased risk for Legionella growth and emission
Authors: van den Berg Harold , Lodder Willemijn , Bartels Alvin , Brandsema Petra , Vermeulen Lucie , Lynch Gretta , Euser Sjoerd , de Roda Husman Ana Maria 
Published: August 2023

Abstract

Legionnaires’ disease (LD) is a severe pneumonia mainly caused by the bacterium Legionella pneumophila. Although many environmental sources of LD have been described, the sources of the majority of non-outbreak LD cases have not been identified. In several outbreaks in the Netherlands, wastewater treatment plants (WWTPs) were identified as the most likely source of infection. In this study, four criteria for Legionella growth and emission to air and surface waters were selected based on the literature and a risk matrix was drafted. An inventory was made of all WWTPs and their characteristics in the Netherlands. The risk matrix was applied to identify WWTPs at risk for Legionella growth and emission. Wastewater was collected at WWTPs with moderate to high risk for Legionella growth and emission. In 18% of the sampled WWTPs, Legionella spp. was detected using culture methods. The presented risk matrix can be used to assess the risks of Legionella growth and emission for WWTPs and support surveillance by prioritizing WWTPs. When Legionella is detected in the wastewater, it is recommended to take action to prevent emission to air or discharge on surface waters and, if possible, reduce the Legionella concentration.
Assessment of groundnut (Arachis hypogaea) as a natural coagulant for water treatment
Authors: Kingue Beryl , Njila Roger , Ndongo Barthelemy 
Published: August 2023

Abstract

Natural coagulants can be an alternative solution to minimise the environmental pollution and health risks caused by the use of chemical coagulants. The main objective of this research was to evaluate the performance of groundnut extract for turbidity removal from water. For this, the active coagulant agents were extracted from the deshelled nuts and used in a series of water treatment tests performed at low, medium, and high turbidity levels using synthetic turbid water. The groundnut extract showed good coagulative abilities, close to those of Al2(SO4)3. The best performance was obtained at medium turbidity (150 NTU), where the extract removed 89% of the turbidity using a 500 mg/L dosage. However, it was not as efficient as Al2(SO4)3, whose coagulation was better at every turbidity level. The use of the groundnut extract does not modify the water's pH significantly and the floc size decreases as turbidity increases, although they are bigger than those produced by Al2(SO4)3. Its flocculation and sedimentation processes are also quick (each less than 10 min) and quicker than those with Al2(SO4)3. Hence, the groundnut extract is a viable alternative to chemical coagulants.
Precipitation prediction based on CEEMDAN–VMD–BILSTM combined quadratic decomposition model
Authors: Zhang Xianqi , Shi Jingwen , Chen Haiyang , Xiao Yimeng , Zhang Minghui 
Published: August 2023

Abstract

Accurate prediction of monthly precipitation is crucial for effective regional water resources management and utilization. However, precipitation series are influenced by multiple factors, exhibiting significant ambiguity, chance, and uncertainty. In this research, we propose a combined model that integrates adaptive noise-complete ensemble empirical mode decomposition (CEEMDAN), variational modal decomposition method (VMD), and bidirectional long- and short-term memory (BILSTM) to enhance precipitation prediction. We apply this model to forecast precipitation in Fuzhou City and compare its performance with existing models, including CEEMD–long and short-term memory (LSTM), CEEMD–BILSTM, and CEEMDAN–BILSTM. Our findings demonstrate that the combined CEEMDAN–VMD–BILSTM quadratic decomposition model yields more accurate predictions and captures the real variation in precipitation series with greater fidelity. The model achieves an average relative error of 1.69%, at a lower level, and an average absolute error of 1.32 m, with a Nash–Sutcliffe efficiency coefficient of 0.92. Overall, the proposed quadratic decomposition model exhibits excellent applicability, stability, and superior predictive capabilities in monthly precipitation forecasting.
TiO2/SO42- Solid Superacid: A Rapid, Solventless, Recoverable Nanocatalyst for
Eco-Friendly Synthesis of Piperidin-4-one Oximes
Authors: Nivetha Narayanasamy , Thangamani Arumugam , Raja Pandian Bothi 
Published: August 2023

:
A potent, eco-friendly approach for converting 2,6-arylpiperidin-4-ones into their
corresponding oximes in the presence of hydroxylamine hydrochloride and catalysed by nanosize
sulfated titania (TiO2/SO4
2-) solid superacid was developed. Sol-gel method was employed
to synthesize the catalyst and confirmed standard characterization techniques viz., by
FT-IR, XRD, TEM, SEM, and EDS analysis. After adding 0.05 g of catalyst, the reaction was
carried out under stirring in an oil bath at 130oC for 3-7 min under solvent-free conditions.
This approach has advantages like catalyst recyclability, high yields, shorter reaction time, and
simple work-up. Additionally, the catalyst TiO2/SO4
2- exhibited good stability, recoverability,
and reusability for five consecutive runs without tremendous loss in its catalytic activity. The
compounds 3a-o were characterised by IR, 1H and 13C NMR spectral analysis. The coupling
constant values in NMR results suggested that the compounds 3a-o exhibit chair conformation with equatorial orientations
with all the substituents. This is in agreement with the X-ray crystallography of 3c, confirming that the
chair conformation of =N-OH group is syn to C-5 and anti to benzyl group at C-3 and hence if forms more stable
(E)-configuration of the oxime 3c.
Bile Acids as Signaling Molecules: Role of Ursodeoxycholic Acid in
Cholestatic Liver Disease
Authors: Cifuentes-Silva Eduardo , Cabello-Verrugio Claudio 
Published: August 2023

Abstract:
Ursodeoxycholic acid (UDCA) is a natural substance physiologically produced in the liver.
Initially used to dissolve gallstones, it is now successfully used in treating primary biliary cirrhosis
and as adjuvant therapy for various hepatobiliary cholestatic diseases. However, the mechanisms
underlying its beneficial effects still need to be clarified. Evidence suggests three mechanisms
of action for UDCA that could benefit humans with cholestatic liver disease (CLD): protection
of cholangiocytes against hydrophobic bile acid (BA) cytotoxicity, stimulation of hepatobiliary
excretion, and protection of hepatocytes against BA-induced apoptosis. These mechanisms
may act individually or together to potentiate them. At the molecular level, it has been observed
that UDCA can generate modifications in the transcription and translation of proteins essential in
the transport of BA, correcting the deficit in BA secretion in CLD, in addition to activating signaling
pathways to translocate these transporters to the sites where they should fulfill their function. Inhibition
of BA-induced hepatocyte apoptosis may play a role in CLD, characterized by BA retention
in the hepatocyte. Thus, different mechanisms of action contribute to the improvement after
UDCA administration in CLD. On the other hand, the effects of UDCA on tissues that possess receptors
that may interact with BAs in pathological contexts, such as skeletal muscle, are still unclear.
This work aims to describe the main molecular mechanisms by which UDCA acts in the human
body, emphasizing the interaction in tissues other than the liver.
Physicochemical Stimulus-Responsive Systems Targeted with
Antibody Derivatives
Authors: Mohammadi Rezvan , Ghani Sepideh , Arezumand Roghaye , Farhadi Shohreh , Khazaee-poul Yalda , Kazemi Bahram , Yarian Fatemeh , Noruzi Somaye , Alibakhshi Abbas , Jalili Mahsa , Aghamiri Shahin 
Published: August 2023

:
The application of monoclonal antibodies and antibody fragments with the
advent of recombinant antibody technology has made notable progress in clinical trials
to provide a regulated drug release and extra targeting to the special conditions in the
function site. Modification of antibodies has facilitated using mAbs and antibody
fragments in numerous models of therapeutic and detection utilizations, such as stimuliresponsive
systems. Antibodies and antibody derivatives conjugated with diverse stimuliresponsive
materials have been constructed for drug delivery in response to a wide
range of endogenous (electric, magnetic, light, radiation, ultrasound) and exogenous
(temperature, pH, redox potential, enzymes) stimuli. In this report, we highlighted the
recent progress on antibody-conjugated stimuli-responsive and dual/multi-responsive
systems that affect modern medicine by improving a multitude of diagnostic and
treatment strategies.