bluuebunny/crossref_metadata_2025_split huggingface dataset:
Single‐cell sequencing of entorhinal cortex reveals widespread disruption of neuropeptide networks in Alzheimer's disease
Authors: Li Manci , Larsen Peter A. 
Published: February 2023

AbstractINTRODUCTIONAbnormalities of neuropeptides (NPs) that play important roles in modulating neuronal activities are commonly observed in Alzheimer's disease (AD). We hypothesize that NP network disruption is widespread in AD brains.METHODSSingle‐cell transcriptomic data from the entorhinal cortex (EC) were used to investigate the NP network disruption in AD. Bulk RNA‐sequencing data generated from the temporal cortex by independent groups and machine learning were employed to identify key NPs involved in AD. The relationship between aging and AD‐associated NP (ADNP) expression was studied using GTEx data.RESULTSThe proportion of cells expressing NPs but not their receptors decreased significantly in AD. Neurons expressing higher level and greater diversity of NPs were disproportionately absent in AD. Increased age coincides with decreased ADNP expression in the hippocampus.DISCUSSIONNP network disruption is widespread in AD EC. Neurons expressing more NPs may be selectively vulnerable to AD. Decreased expression of NPs participates in early AD pathogenesis. We predict that the NP network can be harnessed for treatment and/or early diagnosis of AD.
Association between carotid intima‐media thickness and cognitive decline differs by race
Authors: Ferreira Naomi Vidal , Bertola Laiss , Santos Itamar S. , Goulart Alessandra C. , Bittencourt Marcio S. , Barreto Sandhi Maria , Giatti Luana , Caramelli Paulo , Pereira Alexandre , Lotufo Paulo Andrade , Bensenor Isabela M. , Suemoto Claudia Kimie 
Published: February 2023

AbstractINTRODUCTIONCommon carotid intima‐media thickness (cIMT) is a marker of subclinical atherosclerosis and is associated with cognitive decline. Although carotid atherosclerosis is more frequent in White than in Black participants, little is known whether race modifies the association between cIMT and cognitive decline.METHODSIn this longitudinal analysis of the ELSA‐Brasil, we assessed cIMT using ultrasound and cognitive performance using different domain tests. We used linear mixed models, interaction analysis, and race stratified analyses.RESULTSBaseline high IMT values were associated with memory (p < 0.001), verbal fluency (p < 0.001), TMT‐B (p < 0.001)), and global cognitive decline (p < 0.001). Race was an effect modifier in the association between IMT and global cognitive decline (0.043), with stronger association in White (p < 0.001) than in Black (p = 0.009) participants.DISCUSSIONBaseline IMT was associated with global and domain‐specific cognitive decline and race modified this relationship, with stronger associations in White participants.Highlights
Carotid intima‐media thickness (cIMT) was associated with cognitive decline.
cIMT and cognitive decline association was stronger in White than in Black participants.
We used inverse probability weighting to address attrition bias.
Factors Influencing Perioperative Nurse Turnover: A Classic Grounded Theory Study
Authors: Mayes Carole G. , Cochran Karen 
Published: February 2023

ABSTRACTPerioperative nurse turnover rates range from 12% to 18.8%, and approximately 75% of perioperative managers reported at least one vacancy in 2021. Perioperative leaders are challenged to mitigate nurse turnover effectively because factors contributing to a nurse's decision to leave their job are not well defined. The purpose of this qualitative study using classic grounded theory was to explore perioperative nurses’ turnover decision‐making processes. We used social media to recruit participants and then conducted 26 interviews to collect data. We completed comparative analysis of the data and developed the Perioperative Nurse Turnover Decision‐Making Theory, which describes the influence of the dimensions of perioperative nurse well‐being (ie, physical and emotional well‐being, career development, work‐life balance, compensation, workplace culture) on their decision to leave an OR position. Perioperative leaders should consider the nurses’ decision‐making process when developing and implementing interventions aimed at reducing turnover.
Automating Perioperative Inventory Management: A Quality Improvement Project
Authors: Rocchio Betty Jo , Chipps Esther , Gorsuch Penelope , Wills Celia E. 
Published: February 2023

ABSTRACTPreference cards are a foundation for perioperative inventory management processes; however, they can add to nurses’ perceived workload, introduce variability into supply management processes, and increase costs. The purpose of this quality improvement project was to implement an automated perioperative inventory management system to decrease nurses’ workload and increase their efficiency. Goals included improving preference card accuracy, decreasing add‐on supplies, and decreasing the supply costs for each procedure. Using a preintervention‐postintervention survey design, the project team evaluated the outcomes of workload, preference card accuracy, add‐on supplies, and procedural cost. Nurses’ perception of workload decreased in the supply management processes and cost of supplies categories and increased in the documenting supply use category. A four‐month 7.7% improvement in preference card accuracy reduced the average procedure supply cost by $86.72 for each procedure and saved the hospital $260,467. The number of add‐on supplies was reduced by 4,177 for a 20% reduction.
Chemical combination of nano‐silica and alkaline lignin for property enhancement of polylactic acid‐based composite films
Authors: Gong Yue , Fu Lingying , Ou Zhiqiang , Zhou Qi , Rao Xin , Wang Songbin , Huo Chunqing , Du Xueyu 
Published: February 2023

AbstractAs a key byproduct from alkaline pulping industry, alkaline lignin (AL) exhibits tremendous potentials for the development of high‐value‐added biomaterials, ascribed to its renewability and unique polymeric structure. In this study, the alkaline lignin was first oxidized and then modified with aminated nano‐silica. After further hydrophobic modification with a silane coupling agent, a novel lignin‐based filler was finally prepared and applied for property enhancement of PLA‐based composite films. As revealed from SEM results that, a uniformed state of filler distribution could be achieved if the filler content is no more than 1%. Under this condition, the thermal stability of composite film could be effectively improved, as well as the enhancement of tensile strength (50.7 MPa) and Young's modulus (2847 MPa). Notably, the composite films also exhibit selective resistance against UV lights rather than visible lights, especially at higher filler content.
The ear of the Sima de los Huesos hominins (Atapuerca, Spain)
Authors: Conde‐Valverde Mercedes , Martínez Ignacio , Quam Rolf , Arsuaga Juan Luis 
Published: February 2023

AbstractPrevious studies on the morphology of the inner ear (semicircular canals and cochlea) in the Sima de los Huesos hominin sample have provided important results on the evolution of these structures in the Neandertal lineage. Similarly, studies of the anatomy of the external and middle ear cavities of the Sima de los Huesos hominins have also provided important data on the auditory capacities of this European Middle Pleistocene population. The present contribution provides unpublished data on three new middle ear variables from the Sima de los Huesos fossils and compares these data with values from samples of Pan troglodytes, Homo neanderthalensis and Homo sapiens. The results of this analysis are combined with those obtained in previous studies to characterize the anatomy of the outer, middle and inner ear in the Sima de los Huesos fossils, as well as to establish the order of appearance of the features that characterize Neandertal ears. As in other cranial structures, the ear region in the Sima de los Huesos show a mosaic evolutionary pattern that includes primitive traits, others shared exclusively with Neandertals, and others that are specific to the Sima de los Huesos hominins. Neandertals and Sima de los Huesos hominins share two exclusive features of the middle ear that are among the first characteristics of the Neandertal lineage: a long tympanic cavity and a large entrance and exit of the mastoid antrum. Along with these traits, the Sima de los Huesos hominins present two specialized features: large volumes of the tympanic cavity and the mastoid antrum. Finally, the middle ear of the Neandertals is characterized by the presence of small angles between the tympanic axis and the plane of the oval window.
Resurrecting the power in the stones, developing a modern narrative of the agency and sentience of powerful stones, and recreating shared knowledge encounters at Gummingurru and its associated site architecture
Authors: Thomas E. Jaydeyn , Ross Annie , Bauwens Shannon , Bauwens Conrad 
Published: February 2023

ABSTRACTPrior to European settlement, the Gummingurru stone arrangement was a place of man‐making and knowledge sharing for Aboriginal people from across vast areas of what is now southern Queensland and northern New South Wales, Australia. One of the most powerful sites of ritual and exchange en‐route to the Bunya Mountains, Gummingurru was the place at which boys became adults, were assigned “yurees” (totems), and given Law to inform their roles in society for the rest of their lives. We argue that the stones themselves had agentive power in the creation of men. European invasion brought access to Gummingurru to a temporary end. The site lay dormant for many generations until it was returned to the Jarowair clan of the Wakka Wakka Nation in 2008. Since this time, the Gummingurru stone arrangement and its associated site architecture have been resurrected through the combination of applied archaeological and ethnohistorical research and Aboriginal knowledge. Today Gummingurru is at the centre of a major cultural revival on the Darling Downs. It is the locus of the development of Aboriginal control of reconciliation activities and the establishment of a power‐base for the management of both the Gummingurru and Bunya Mountains landscapes, with the stones themselves acting to control the process.
Research on the application of the blended BOPPPS based on an online and offline mixed teaching model in the course of fermentation engineering in applied universities
Authors: Li Siqiang , Liu Quanlan , Guo Shuang , Li Yun , Chen Fujia , Wang Chunhong , Wang Mingcheng , Liu Junhe , Liu Xianli , Wang Duanhao , Li Enzhong 
Published: February 2023

AbstractThis study aimed to investigate the teaching effect of the blended BOPPPS based on an online and offline mixed teaching model (“B + BOPPPS”) in the course of fermentation engineering in applied universities. The participants were 142 undergraduates majoring from the course of fermentation engineering in Food Science and Engineering in 2019 and 2020 in Huanghuai University, Zhumadian city, Henan province, China. The students in the control group (68 students) were taught in 2019, and the students in the experimental group (74 students) were taught in 2020. The traditional teaching method and “B + BOPPPS” were implemented, respectively. The teaching effect was evaluated using the questionnaire survey of course satisfaction and theoretical knowledge test. The results showed that the scores of the theoretical knowledge test in the experimental group adopting “B + BOPPPS” were significantly higher than those in the control group, and the difference was statistically significant (p < 0.01). The students had a good evaluation of the “B + BOPPPS” in many aspects, which included achieving learning goals, providing in‐depth understanding of knowledge points, stimulating interest in learning, training in the ability to analyze and think about problems, and so on. The results suggested that “B + BOPPPS” could stimulate students' interest in learning and improve their subjective initiative. They could also improve students' ability to master and apply knowledge, which was conducive to improving the theoretical teaching quality of the course of fermentation engineering.
Corporate waste disclosure, risk‐taking and foreign ownership: Evidence from Indonesia
Authors: Wulansari Winda , Adhariani Desi 
Published: February 2023

AbstractThe role of corporations in waste management can reflect the superior performance in innovation and the risk a company is willing to take to engage in the circular economy. The superior performance of corporate waste management can be reflected in the corporate disclosure as a media of accountability and transparency. This research investigates the association between waste disclosure and corporate risk‐taking and the moderating role of foreign ownership in companies in Indonesia as an emerging country struggling to find an effective solution toward environmental problems, including waste. The observation was performed on non‐financial companies listed on the Indonesian Stock Exchange for the period 2018–2021. Panel regression was used to find the answers to the research questions of the direct and moderate associations among corporate waste disclosure, risk‐taking and foreign ownership. The results show that waste disclosure encourages increased corporate risk‐taking, which means that companies that disclose waste are companies with good accountability and environmental performance and tend to take risks that can increase value. Foreign ownership was not found to statistically strengthen the relationship between waste disclosure and corporate risk‐taking, which is different from the expectation that improving the transparency of waste information can attract a greater inflow of foreign investor resources. This brings implication that investors need to increase attention to the issue of corporate waste management and put pressure on companies to provide information on corporate waste performance for investment decision‐making. Furthermore, the results of the study also found that waste disclosure in Indonesia is still low compared to the international disclosure standard. This research contributes to the sustainability accounting literature in developing countries by outlining the role of waste disclosure.
Bridging the valley of death in the EU renewable energy sector: Toward a new energy policy
Authors: Muscio Alessandro , Simonelli Felice , Vu Hien 
Published: February 2023

AbstractThe European Union (EU) has committed to becoming a global leader in renewable energy. Reaching this target implies fostering innovation activity to maximize the competitiveness of the European renewable industry. By relying on a case study approach based on a small number of in‐depth interviews with selected stakeholders, this paper illustrates one of the main factors hindering technological development in the renewable energy sector in Europe. More specifically, the paper focuses on the so‐called “valley of death,” which traps promising technologies in a “limbo.” While ready to be deployed from a technical standpoint, these technologies are not cost competitive and, paradoxically, only their widespread commercialization would allow to drive their cost down. The paper also identifies a mix of policy solutions that can effectively support the competitiveness of the EU renewable energy industry. While more public funding to deploy promising renewable energy technologies is certainly needed, EU policymaker should also improve synergies between EU funding programs at all stages of the research and innovation process. In addition, introducing an EU risk insurance and guarantee fund would ultimately allow to reduce deployment costs and boost commercialization of new technologies.
Screening for DAX1/EWS‐FLI1 functional inhibitors identified dihydroorotate dehydrogenase as a therapeutic target for Ewing's sarcoma
Authors: Watanabe Miwa , Kosaka Hiromichi , Sugawara Masamori , Maemoto Michihiro , Ono Yoko , Uemori Takeshi , Shizu Ryota , Yoshinari Kouichi 
Published: February 2023

AbstractObjectiveEWS‐FLI1 is the most common oncogenic fusion protein in Ewing's sarcoma family tumors (ESFTs). DAX1, an orphan member of the nuclear receptor superfamily, is up‐regulated by EWS‐FLI1 and plays a key role in the transformed phenotype of ESFTs.MethodsTo discover a functional inhibitor of DAX1 and EWS‐FLI1, we screened small‐molecular inhibitors using a DAX1 reporter assay system.ResultsK‐234 and its derivatives, which were dihydroorotate dehydrogenase (DHODH) inhibitors, showed inhibitory effects in the reporter assay. K‐234 inhibited the growth of Ewing's sarcoma with various fusion types, and K‐234 derivatives altered the expression of EWS‐FLI1‐regulated genes. The DAX1 expression had no effect on the growth inhibitory effect of the K‐234 derivatives, while DHODH overexpression or uridine treatment attenuated their inhibitory effects, suggesting that inhibition by K‐234 derivatives occurs through DHODH inhibition. An in vivo study showed that a K‐234 derivative clearly inhibited tumor growth in an Ewing's sarcoma xenograft mouse model.ConclusionTaken together, the present results suggest that DHODH inhibitors can inhibit the function of DAX1/EWS‐FLI1 in ESFTs and might be a therapeutic agent with potent anti‐tumor activity for Ewing's sarcoma patients.
Metal Complexes in Cancer Treatment: Journey So Far
Authors: Kumar Singh Ankit , Kumar Adarsh , Singh Harshwardhan , Sonawane Pankaj , Pathak Prateek , Grishina Maria , Pal Yadav Jagat , Verma Amita , Kumar Pradeep 
Published: February 2023

AbstractMetal complexes in cancer therapy have attracted much interest mainly because metals exhibit unique characteristics, such as redox activity, metal‐ligand interaction, structure and bonding, Lewis acid properties etc. In 1965, Barnett Rosenberg serendipitously discovered the metal‐based compound cisplatin, an outstanding breakthrough in the history of metal‐based anticancer complexes and led to a new area of anticancer drug discovery. Many metal‐based compounds have been studied for their potential anticancer properties. Some of these compounds have FDA approval for clinical use, while others are now undergoing clinical trials for cancer therapy and detection. In the present study, we have highlighted the primary mode of action of metallic complexes and all FDA‐approved/under clinical trial drugs with reference to cancer treatment. This review also focuses on recent progress on metal‐based complexes such as platinum, ruthenium, iron, etc. with potential anticancer activities.
Free‐radical propagation rate coefficients
Authors: Buback Michael 
Published: February 2023

AbstractThe pulsed laser polymerization‐size‐exclusion chromatography (PLP‐SEC) technique has become the International Union of Pure and Applied Chemistry (IUPAC)‐recommended method for the accurate determination of propagation rate coefficients, kp, for radical polymerization. The fundamental insight provided by Heuts, Gilbert, and Radom into the relevance of transition state dynamics allows for an adequate understanding of the dependence of kp on radical chain length, solvent environment, and monomer conversion. The associated entropic effects are particularly pronounced in aqueous solution, but are also found in less polar media and with non‐polar monomers. Moreover, these arguments are applicable towards the interpretation of copolymerization reactivity ratios. The addition of sodium hydroxide to aqueous solutions of (meth)acrylic acid yields partially and even fully ionized systems with clearly reduced kp, which indicates the action of repulsive forces between the equally charged monomer and radical species. Increasing the concentration of monomer as well as the addition of salts may reverse this effect and increase kp due to counterion activity.
Single Modification at the N‐Terminus of Norvancomycin to Combat Drug‐Resistant Gram‐Positive Bacteria
Authors: Guan Dongliang , Chen Feifei , Shi Wei , Lan Lefu , Huang Wei 
Published: February 2023

AbstractIn the arsenal of glycopeptide antibiotics, norvancomycin, which differs from vancomycin by a single methyl group, has received much less attention. Facing the risks of serious antibiotic resistance and even the collapse of last‐line defenses, we designed and synthesized 40 novel norvancomycin derivatives to combat the threat. 32 compounds are single N‐terminally modified derivatives generated through simple and efficient methods. Diversity at the N‐terminus was greatly enriched, mainly by lipophilic attachment and strategies for the introduction of lipo‐sulfonium moieties for extensive structure–activity relationship analysis. The first incorporation of a sulfonium moiety into the norvancomycin structure gave rise to compounds that exhibited 4‐ to 2048‐fold higher activity against vancomycin‐resistant bacteria VISA and VRE. This N‐terminal modification for norvancomycin provides an alternatively useful and promising strategy to restore the antibacterial activity of glycopeptide antibiotics against resistant bacteria, highlighting the same importance of the N‐terminal site as well as the vancosamine position, which is worth further study and development.
Double BAC and Triple BAC: A Systematic Analysis of the Disinfectant Properties of Multicationic Derivatives of Benzalkonium Chloride (BAC)
Authors: Toles Zachary E. A. , Wu Alice , Sanchez Christian A. , Michaud Marina E. , Thierer Laura M. , Wuest William M. , Minbiole Kevin P. C. 
Published: February 2023

AbstractOver the past decades, the shortcomings of established quaternary ammonium disinfectants have become increasingly clear. Although benzalkonium chloride (BAC) has enjoyed nearly a century of significantly protecting human health through surgical preparation, home use, and industrial applications, increasing levels of bacterial resistance have rendered it decreasingly effective. In light of more recent efforts that have informed us that multicationic amphiphilic disinfectants show both higher activity as well as diminished susceptibility to resistance, we embarked on the preparation of 27 multicationic QACs in an attempt to clearly document structure‐activity relationships of next‐generation BAC structures. Select biscationic BAC derivatives demonstrate single‐digit micromolar activity against all seven bacteria tested and MIC values of 2‐ to 32‐fold better than BAC. Particularly notable is the improvement against the more concerning bacteria like Acinetobacter baumannii and Pseudomonas aeruginosa, which pose a modern threat to legacy disinfectants like BAC. With simple synthetic paths, consistently high yields (averaging ∼80 %), and strong biological activity, potent structures with clear SAR trends and strong therapeutic indices have been established.