bluuebunny/crossref_metadata_2025_split huggingface dataset:
Estimating and managing broad risk of chronic wasting disease spillover among cervid species
Authors: Mysterud Atle , Solberg Erling J. , Meisingset Erling L. , Panzacchi Manuela , Rauset Geir Rune , Strand Olav , Van Moorter Bram , Rolandsen Christer M. , Rivrud Inger Maren 
Published: September 2023

AbstractThe management of infectious wildlife diseases often involves tackling pathogens that infect multiple host species. Chronic wasting disease (CWD) is a prion disease that can infect most cervid species. CWD was detected in reindeer (Rangifer tarandus) in Norway in 2016. Sympatric populations of red deer (Cervus elaphus) and moose (Alces alces) are at immediate risk. However, the estimation of spillover risk across species and implementation of multispecies management policies are rarely addressed for wildlife. Here, we estimated the broad risk of CWD spillover from reindeer to red deer and moose by quantifying the probability of co‐occurrence based on both (1) population density and (2) habitat niche overlap from GPS data of all three species in Nordfjella, Norway. We describe the practical challenges faced when aiming to reduce the risk of spillover through a marked reduction in the population densities of moose and red deer using recreational hunters. This involves setting the population and harvest aims with uncertain information and how to achieve them. The niche overlap between reindeer and both moose and red deer was low overall but occurred seasonally. Migratory red deer had a moderate niche overlap with the CWD‐infected reindeer population during the calving period, whereas moose had a moderate niche overlap during both calving and winter. Incorporating both habitat overlap and the population densities of the respective species into the quantification of co‐occurrence allowed for more spatially targeted risk maps. An initial aim of a 50% reduction in abundance for the Nordfjella region was set, but only a moderate population decrease of less than 20% from 2016 to 2021 was achieved. Proactive management in the form of marked population reduction is invasive and unpopular when involving species of high societal value, and targeting efforts to zones with a high risk of spillover to limit adverse impacts and achieve wider societal acceptance is important.
Quality control of camellia oil based on HPLC fingerprinting techniques combined with chemometric methods for triglycerides
Authors: Mo Luyan , Qian Junqing , Li Qian , Huang Aomei , Guo Hui 
Published: September 2023

AbstractTriglycerides (TAGs) play an important role in the physiological function of vegetable oils. Camellia oil has a variety of good physiological functions. Therefore, a qualitative and quantitative method for the determination of TAGs in camellia oil by high‐performance liquid chromatography‐diode array detector/electro spray ionization mass spectrometry was developed. The 16 TAGs that separated were identified and quantified by peak‐area normalization. In addition, the major TAGs in camellia oil were OOO (25.25%), OLO (20.72%), POL (9.23%), OLL (8.22%), and OOP (8.22%). Moreover, the content of oleic acid in camellia oil was 81.74%. Using fingerprint techniques, 15 common peaks in 12 samples were selected as characteristic peaks to evaluate the differences in the composition of camellia oil samples. In addition, the samples were further classified by chemometric methods. It is shown that the camellia oil samples with high similarity from two cities in the main producing areas of Zhejiang province could be further classified according to the planting areas by the combination of chromatographic fingerprints and chemometric methods.
Leveraging technology adoption to navigate the 4IR towards a future‐ready business: A systematic literature review
Authors: Kruger Sean , Steyn Adriana A. 
Published: September 2023

AbstractThe purpose of this study was to analyze technology adoption constructs that are instrumental for organizations to effectively utilize emerging technologies, enabling them to navigate the complexities and opportunities presented by the fourth industrial revolution (4IR). To achieve this a descriptive research approach was used, guided by a systematic review of literature from 2016 to 2022. Among the 4037 studies initially identified, only 69 were deemed relevant. Meta‐synthesis was then used to systematically identify, categorize, and quantify fundamental constructs inherent in the models from the relevant literature. As a result of this process, 406 constructs were identified across six thematic categories. These were subsequently integrated to develop a conceptual model that can be used to coordinate strategies to harness the potential of the 4IR towards a future‐ready business. Findings show that the role of technology adoption remains pertinent in the ever‐digitized world in which businesses operate and certain constructs are key to explain, support, and predict enterprise‐wide adoption in the 4IR paradigm. Future studies can expand and test the model to promote digital fluency required by business constituents, noting differences across sectors.
Physicochemical characterization, biodistribution, and bio‐effects of fluorescent carbon dots from roasted Spanish mackerel
Authors: Cui Guoxin , Li Jiaqi , Li Jiaxuan , Wang Haitao , Tan Mingqian 
Published: September 2023

AbstractNanoparticles with small sizes formed in the process of food thermal treatment have gained substantial attention due to their safety uncertainty and latent risks to human health. Herein, the physicochemical features of fluorescent carbon dots (CDs) from roasted Spanish mackerel were studied, it was found that the size distribution, fluorescence properties, surface groups, and formation process of CDs were highly dependent on the roasting time of Spanish mackerel. The interaction of CDs with digestive proteases resulted in the structural change and activity inhibition of proteases. When the concentration of CDs was 120 μg mL−1, the enzyme activity of pepsin and trypsin was reduced from 100% to 75.95% and 78.5%, respectively. The CDs caused static fluorescence quenching of pepsin and trypsin as confirmed by the fluorescence analysis. After oral administration, CDs can be transported to the main organs through the blood. The cytotoxicity assessment revealed that the cell viability decreased with the prolonging of roasting time. The CDs roasted at 230°C for 40 min showed a significant hemolytic effect even at a low concentration of 0.5 mg mL−1. Moreover, the cellular uptake level and pathway of CDs were significantly affected by blood protein adsorption. This study helps to evaluate the in vivo biodistribution, the interaction with proteases during gastrointestinal digestion, and the cellular uptake of CDs after transport through the blood, providing a theoretical basis for revealing the potential effects of foodborne nanoparticles.
The in vivo and in vitro protein quality of three hemp protein sources
Authors: Nosworthy Matthew G. , Franczyk Adam , Neufeld Jason , House James D. 
Published: September 2023

AbstractIn this work, the protein quality of defatted hemp hearts and protein‐enriched hemp fractions was determined. Protein quality was assessed using a rodent bioassay to evaluate growth and protein digestibility, while amino acid composition was determined via HPLC. A method for determining in vitro protein digestibility was compared to in vivo methodology and used to generate an in vitro protein quality score. The true protein digestibility of hemp protein 2, a hemp protein concentrate, was significantly lower than that of either defatted hemp hearts or hemp protein 1, a hemp protein concentrate (p < .05). While there was no relationship between the in vivo and in vitro measurements of protein digestibility (R2 = .293, p = .459), there was a significant correlation between the protein digestibility‐corrected amino acid score (PDCAAS) determined in vivo and in vitro PDCAAS (R2 = .989, p = .005). The protein efficiency ratio of hemp protein 1 was significantly lower than that of either defatted hemp hearts or hemp protein 2 (p < .05). These data highlight the nutritional capacity of hemp protein sources while also demonstrating the relationship between in vivo and in vitro methods for determining protein quality.
Quaternary sediment datasets for spatial distribution and accumulation on the Yarlung Tsangpo River Basin based on remote sensing and field on‐site measurements
Authors: Bai Yalige , Lin Zhipeng , Han Zhongpeng , Wang Xinhang , Wang Chengshan 
Published: September 2023

AbstractQuaternary unconsolidated sediments are pronouncedly widespread features on the planetary surface, documenting significant geological signals of earth surface processes, climate change and biogeochemical cycles. The extensive unconsolidated deposits play a vital role in natural hazards and Anthropogenic activities, especially in alpine regions where massive unconsolidated materials are produced. However, the spatial distribution and total volume of unconsolidated sediments across the Yarlung Tsangpo River Basin (YTRB) remain largely unknown due to the limitation of traditional field surveys and on‐site measurements as well as the complex landscape in the remote area. This study presents the datasets for the systematic distribution and spatial accumulation of unconsolidated sediments across the Yarlung Tsangpo River Basin, southern Tibet. Combining remotely sensed data with numerous field investigations, an integrated method based on image processing and kriging interpolation‐pixel integration was performed to semi‐automatically classify and quantify the unconsolidated sediments. Eleven categories of sediments were mapped and their total accumulation is estimated at approximately 4.97 × 1011 t. Ultimately, 17 groups of classification and thickness maps were derived, revealing the distribution and volume of unconsolidated and Quaternary sediments. The datasets fill the gaps in comprehensive investigations of unconsolidated sediments for YTRB, and provide a fundamental database to support the scientific understanding of potential linkages between the distribution of unconsolidated sediments with environmental changes and human activities.
Prevalence and determinants of resistant hypertension in the delta region of Egypt: A prospective observational study
Authors: Elbarbary Mohammed , Shoeib Osama , El‐saied Shaimaa B. , Atlm Ramy M. , Alkassas Amr 
Published: September 2023

AbstractBackground and AimsHypertension (HTN) is a leading cause of morbidity and mortality affecting about 30%–40% of the adult population in developed countries. Fewer data were published about the prevalence, sociodemographics, and clinical characteristics of the resistant hypertensive population in Egypt. Hence, our aim is to focus the attention on these determinants especially in the delta region of Egypt.MethodsData belonging to patients visiting our HTN clinic in the Cardiovascular Department, Tanta University Hospital, Gharbeyah Governorate, Egypt, were collected over 12 months, between January 1, 2022, and 31 December 31, 2022, and then carefully analyzed.ResultsWe found that the prevalence of resistant hypertension (RHTN) in the delta region of Egypt was 18%. We noted more RHTN cases in older age, that is, mean ± Std. was 51.5 ± 13.24 and 62.1 ± 7.56 for non‐RHTN and RHTN, respectively. Also, the prevalence was higher in women representing about 54.4% of cases. Sixty‐two percent of the patients with RH were obese (mean ± Std. of body mass index was 30.7 ± 5.36 in HTN and 47.7 ± 30.3 in RHTN groups with p value <0.001). We found a significant relationship between chronic kidney disease, diabetes, and RHTN.ConclusionControl of HTN among the Egyptian population in the delta region was unsatisfactory and higher than rates published globally. RH was more obvious in women, elderly, obese population, and diabetic and chronic kidney disease patients. Excessive use of nonsteroidal anti‐inflammatory drugs, smoking, and high salt intake were clearly observed.
Chiral supramolecular nanomaterials: From chirality transfer and amplification to regulation and applications
Authors: Chen Wenrui , Li Boran , Gao Guanbin , Sun Taolei 
Published: September 2023

AbstractChirality is an omnipresent structural feature found in nature. The transfer and amplification of chirality are widely recognized phenomena. In appropriate solvents, chiral molecules can self‐assemble into diverse chiral supramolecular nanomaterials with unique properties. In the past two decades, there has been a growing number of reported chiral supramolecular nanomaterials. Significant advancements have been made in the transfer and amplification of chirality within these materials, as well as their regulation and applications. Therefore, it is essential to summarize the progress made in this field. Here we present a comprehensive overview of the latest advancements in chiral supramolecular nanomaterials, ranging from chirality transfer and amplification to regulation and applications. This review aims to deepen our understanding of the fundamental origins of inherent chirality in the chiral supramolecular nanomaterials, while also providing a reference for expanding their potential applications.
Exploring the Sequence Space of Antimicrobial Peptide Dendrimers
Authors: Cai Xingguang , Capecchi Alice , Olcay Basak , Orsi Markus , Javor Sacha , Reymond Jean‐Louis 
Published: September 2023

AbstractThere is an urgent need to develop new antibacterial agents against multidrug resistant bacteria. Herein we report our investigation of antimicrobial peptide dendrimers (AMPDs) active against Gram‐negative bacteria, whose sequences were designed using a genetic algorithm optimizing molecular similarity to the previously reported AMPD T7 with sequence (KL)8(KKL)4(KKLL)2KKKL. Our computational approach selected analogues unlikely to emerge from a systematic study, including AMPD X66 with a non‐conservative Leu→Glu mutation at the dendrimer core which proved compatible with antibacterial effects. Circular dichroism showed that this AMPD is α‐helical. Molecular dynamics suggest that its α‐helical structure is stabilized by an intramolecular salt bridge involving the core glutamate side chain and a lysine side chain in the dendrimer branches. More substantial variations at the dendrimer core were also tolerated such as the installation of the dianionic pegylated fatty acid side chain of the drug semaglutide potentially useful for in vivo studies.
Prevention and elimination efforts of HIV/AIDS caused by sexual violence against women in the Democratic Republic of the Congo: An editorial
Authors: Ciswaka Henoch , Oduoye Malik Olatunde , Masimango Gaston , Bavurhe Rodrigue Fikiri , Bulondo Daniel , Biamba Chrispin , Kibukila Fabrice , Feza Pamela , Akilimali Aymar , Nyakio Olivier 
Published: September 2023

SynopsisHIV is a major public health problem in the Democratic Republic of the Congo due to its high incidence and prevalence and its continuing spread.
Association between anti‐endothelial antigen antibodies and allograft rejection in kidney transplantation
Authors: Lee Hyun Ji , Shin Kyung‐Hwa , Kim Il Young , Choi Byung Hyun , Kim Hyung‐Hoi 
Published: September 2023

AbstractBackgroundEndothelial cells are vital in the transplant immune system as semiprofessional antigen‐presenting cells. Few studies have investigated the importance of anti‐endothelin subtype A receptor (ETAR) antibodies in kidney transplantation. Here, we aimed to analyze the association between anti‐angiotensin II type I receptor (AT1R) and anti‐ETAR antibodies and the association between the presence of anti‐endothelial antibodies and the risk of allograft rejection in kidney transplantation.MethodsIn total, 252 patients who underwent kidney transplantation were enrolled in this study. Antibodies for human leukocyte antigens (HLAs) and non‐HLAs were analyzed immediately before transplantation. Patients were categorized based on the occurrence of antibody‐mediated rejection (AMR) or T‐cell‐mediated rejection (TCMR) by 2017 Banff classification. All p‐values were two‐tailed, and statistical significance was set at p < 0.05.ResultsPatients with anti‐AT1R antibodies had a 3.49‐fold higher risk of TCMR than those without anti‐AT1R antibodies. Patients with anti‐ETAR antibodies had a 5.84‐fold higher risk of AMR than those without anti‐ETAR antibodies. The hazard ratio of AMR in patients with both HLA DSAs and anti‐ETAR antibodies, relative to patients without anti‐ETAR antibodies and HLA DSAs, was 32.85 (95% CI = 1.82–592.91).ConclusionOur findings indicated that anti‐ETAR antibodies are associated with AMR, and patients with both anti‐ETAR antibodies and de novo HLA DSAs were at a high risk of AMR.
Garetosmab in Fibrodysplasia Ossificans Progressiva: Clinical Pharmacology Results from the Phase 2 LUMINA‐1 Trial
Authors: Wang Yuhuan , Nguyen Jenny‐Hoa , de Ruiter Ruben D. , Mendell Jeanne , Srinivasan Dushyanth , Davis John D. , Eekhoff E. Marelise W. 
Published: September 2023

AbstractHere, we report the clinical pharmacology data from LUMINA‐1 (NCT03188666), a Phase 2 trial that evaluated garetosmab (a monoclonal antibody against activin A) in patients with fibrodysplasia ossificans progressiva. Forty‐four patients were randomly assigned to intravenous 10 mg/kg of garetosmab or placebo every 4 weeks in a double‐blind 28‐week treatment period, followed by a 28‐week open‐label treatment period with garetosmab, and subsequent open‐label extension. Serum samples were obtained to assess pharmacokinetics (PK), immunogenicity, and bone morphogenetic protein 9 (BMP9). Comparative exposure–response analyses for efficacy and safety were performed with trough concentrations (Ctrough) of garetosmab prior to dosing. Steady‐state PK was reached 12‐16 weeks after the first dose of garetosmab, with mean (standard deviation) Ctrough of 105 ± 30.8 mg/L. Immunogenicity assessments showed anti‐garetosmab antibody formation in 1 patient (1/43; 2.3%); titers were low, and did not affect PK or clinical efficacy. Median concentrations of BMP9 in serum were approximately 40 pg/mL at baseline. There were no meaningful differences in PK or BMP9 concentration–time profiles between patients who did and did not experience epistaxis or death. The comparative exposure–response analyses demonstrated no association between Ctrough and efficacy or safety. PK findings were consistent with prior data in healthy volunteers and were typical for a monoclonal antibody administered at doses sufficient to saturate target‐mediated clearance. There were no trends that suggested patients with higher serum exposures to garetosmab were more likely to experience a reduction in heterotopic ossification or adverse events. Garetosmab is being further evaluated in the Phase 3 OPTIMA trial.
Pregnancy outcome in Refsum disease: Affected fetuses and children born to an affected mother
Authors: Dubot Patricia , Astudillo Léonardo , Touati Guy , Baruteau Julien , Broué Pierre , Roche Sandrine , Sabourdy Frédérique , Levade Thierry 
Published: September 2023

AbstractWe describe the case of a young woman, from a consanguineous family, affected by adult Refsum disease (ARD, OMIM#266500). ARD is a rare peroxisomal autosomal recessive disease due to deficient alpha‐oxidation of phytanic acid (PA), a branched‐chain fatty acid. The accumulation of PA in organs is thought to be responsible for disease symptoms. The patient presented only bilateral shortening of metatarsals and has been treated with a low‐PA diet. She is homoallelic for the c.135‐2A > G mutation of PHYH, and she married her first cousin carrying the same mutation. She was pregnant seven times and had two homozygous girls. Due to a potential exacerbation of the disease during the third trimester of pregnancy, her weight and plasma PA levels were monitored. No specific events were noticed for the mother during the pregnancies and postpartum periods. This case also raised the question of potential exposure to PA (and its subsequent toxicity) of a homozygous fetus in a homozygous mother. Despite modestly elevated plasma concentrations of PA at birth (<30 μmol/L), the two affected girls did not present any specific sign of ARD and have so far developed normally. As only a few determinations of plasma PA levels in the mother could be performed during pregnancies, showing mild elevations (<350 μmol/L), it remains difficult to conclude as to a possible transplacental crossing of PA.
Impaired fat oxidation during exercise in multiple acyl‐CoA dehydrogenase deficiency
Authors: Madsen Karen L. , Preisler Nicolai , Buch Astrid E. , Stemmerik Mads G. , Laforêt Pascal , Vissing John 
Published: September 2023

AbstractWe investigated the in vivo skeletal muscle metabolism in patients with multiple acyl‐CoA dehydrogenase deficiency (MADD) during exercise, and the effect of a glucose infusion. Two adults with MADD on riboflavin and l‐carnitine treatment and 10 healthy controls performed an incremental exercise test measuring maximal oxidative capacity (VO2max) and a submaximal exercise test (≤1 hour) on a cycle ergometer. During submaximal exercise, we studied fat and carbohydrate oxidation, using stable isotope tracer methodology and indirect calorimetry. On another day, the patients repeated the submaximal exercise receiving a 10% glucose infusion. The patients had a lower VO2max than controls and stopped the submaximal exercise test at 51 and 58 minutes due to muscle pain and exhaustion. The exercise‐induced increase in total fatty acid oxidation was blunted in the patients (7.1 and 1.1 vs 12 ± 4 μmol × kg−1 × min−1 in the healthy controls), but total carbohydrate oxidation was higher (67 and 63 vs 25 ± 11 μmol × kg−1 × min−1 in controls). With glucose infusion, muscle pain decreased and average heart rate during exercise dropped in both patients from 124 to 119 bpm and 138 to 119 bpm. We demonstrate that exercise intolerance in MADD‐patients relates to an inability to increase fat oxidation appropriately during exercise, which is compensated partially by an increase in carbohydrate metabolism.
Hyperornithinemia‐hyperammonemia‐homocitrullinuria syndrome in pregnancy: Considerations for management and review of the literature
Authors: Ho Bernice , MacKenzie Jennifer , Walia Jagdeep , Geraghty Michael , Smith Graeme , Nedvidek Julie , Guerin Andrea 
Published: September 2023

AbstractHyperornithinemia‐hyperammonemia‐homocitrullinuria (HHH) syndrome is a rare metabolic autosomal recessive urea cycle disorder. Only about 100 patients have been reported in the literature. As the population survives into reproductive years, pregnancy management becomes a new challenge for this clinicians. To our knowledge, there are less than three patients with successful pregnancies and deliveries found in the literature with no specific consensus on management or recommendations for HHH syndrome. We reviewed the current literature regarding pregnancy outcomes, combine it with our experience managing a patient through two successful pregnancies and identify a new concern of fetal intrauterine growth restriction. From this, recommendations for pregnancy management are made, including a detailed protocol for clinicians to use for disease management at delivery and in the post‐partum period.