bluuebunny/crossref_metadata_2025_split huggingface dataset:
Error performance analysis for chaotic pulse width position modulation in free space optical communication system
Authors: Narang Ghanishtha , Aggarwal Mona , Kaushal Hemani , Ahuja Swaran 
Published: September 2023

Abstract
In this paper, a pulse time modulation method called chaotic pulse width position modulation (CPWPM) is studied for free space optical communication system. This is a digital modulation technique that combines pulse position modulation and pulse width modulation with chaos. In this scheme, the binary information is carried by both the position and width of the pulses, which are modulated by a chaotic signal. Hence, on a single pulse, two bits of information are encoded, which results in higher bit rates, better privacy, and larger effective bandwidth as compared to chaotic pulse position modulation (CPPM) and chaotic pulse width modulation (CPWM) techniques. Probability of error is investigated for different FSO scenarios, i.e., varying turbulence conditions and link lengths for CPWPM scheme. Finally, the performance of CPWPM-FSO system is compared with a commonly used differential chaos shift keying (DCSK) scheme. CPWPM-FSO system shows comparable results as DCSK-FSO system (for probability of error, P

e
= 10−4 average signal-to-noise ratio (SNR) required for DCSK and CPWPM scheme is 40 dB and 41 dB, respectively, for same length and system conditions), while data rate is doubled in latter, and this verifies the validity of using CPWPM in FSO communication system.
Reduction of PAPR in OTFS signal using airy special function
Authors: Bitra Hanumantharao , Anusha Chillapalli , Pradhan Nrusingha Charan 
Published: September 2023

Abstract
Orthogonal time frequency space (OTFS) is a new two dimensional modulation technique that use the delay-Doppler domain. Despite the fact that OTFS can handle time varying channels and high Doppler scenarios, it has a high Peak-to-Average Power Ratio (PAPR). In this study, we developed an airy-based companding technique for the OTFS signal to address this issue. The airy function is a particular function that is commonly used in optics. We evaluate the proposed airy based companded OTFS with various companding techniques in order to assess its performance. Simulations signify that the proposed airy based companding outperforms the rooting companding, and μ − law companding in terms of both PAPR and instantaneous to average power ratio (IAPR).
Effect of temperature and rolling direction on the formability of CP2 and Ti-6Al-4V titanium materials
Authors: Gökmen Şaban , Ertan Rukiye , Özgül Hande Güler 
Published: September 2023

Abstract
Pure (CP2) and alloyed titanium (Ti-6Al-4V) have an important place in biomedical and aerospace applications due to their low density and high strength properties. In this study, the effect of the formability of CP2 and Ti-6Al-4V titanium alloy at different temperatures on mechanical properties and microstructure was investigated. The hot forming process was carried out by pressing 1 mm sheet titanium plates at different temperatures on the U profile mold. Specimens along the rolling direction and perpendicular to the rolling direction were taken from the bottom the formed U-plates. Afterward, tensile tests, microhardness measurements, and changes in microstructure were examined, respectively. As a result, at high temperatures and in different rolling directions, significant changes in microstructure and mechanical properties were observed. It was determined that the best forming temperature of CP2 and Ti-6Al-4V materials along the rolling direction was 500 °C, white it is 400° for perpendicular to the rolling direction was 400 °C.
From the Traditionalists to GenZ: conceptualizing intergenerational communication and media preferences in the USA
Authors: Gao May Hongmei 
Published: September 2023

Abstract

Purpose
This paper categorizes the seven generations of people living in the USA with a 15-year per generation matrix. This paper presents the communication styles of five generations active as employees and consumers in the USA today: the Traditionalists, Baby Boomers, Generation X, Millennials (GenY), and GenZ. This paper provides strategies for more efficient intergenerational communication.

Design/methodology/approach
This paper is the result of a multi-method qualitative research that crystallizes data from in-depth interviews with ten entrepreneurs in global business and participant observation as a college professor for GenY and GenZ students.

Findings
Organizations need to consider adopting generation specific social media apps for two-way communication. This paper unveils the communication preferences of five generations currently active in the workforce and marketplace in the USA: The Traditionalists, Baby Boomers, Generation X, Millennials (GenY), and GenZ.

Practical implications
For the sustainability of any organization, it is critical to study the communication preferences of the five generations active in the workforce and marketplace in the USA today. In order to achieve intergenerational communication efficiency, companies/organizations need to (1) Conceptualize intergenerational communication as a form of intercultural communication; (2) Craft clear “vision statements;” (3) Communicate with simple language to all generations; (4) Engage in two-way communication via mass media and social media.

Theoretical and social implications
The ongoing digital transformation has a dramatic impact on organizational communication in the USA. Applying the “Speech Code Theory” and “News Find Me” perspective, this research proposes viewing intergenerational communication as intercultural communication. Companies and organizations face challenges with managing, incorporating, and engaging with five generations of employees and customers who grew up in different economic eras, impacted by different technologies and media.

Originality/value
This is the first academic study that synthesizes communication preferences of five generations active in the workforce and marketplace in the USA. This multi-method approach incorporates first hand data from in-depth interviews with ten global business leaders from the generations of Traditionalist, Baby Boomers, and Generation X, as well as participant observation as a professor in the USA for students in GenY (Millennials) and GenZ generations.
A rare FBXO25–SEPT14 fusion in a patient with chronic myeloid leukemia treatment to tyrosine kinase inhibitors: a case report
Authors: Liao Yun , Liu Jiayue , Wei Mengyu , Chen Rongrong , Chen Xiaomin , Zhong Haoshu , Liu Yang , Xiong Hao , Huang Chunlan 
Published: September 2023

Abstract

Objectives
Exploring the pathogenesis of resistance to tyrosine kinase inhibitors in patients with chronic myeloid leukemia.

Case presentation
This case report describes a rare fusion of FBXO25 and SEPT14 genes in a 58-year-old male patient with chronic myeloid leukemia. The patient had been treated with tyrosine kinase inhibitors for one year. After 6 months of imatinib treatment, the patient's symptoms improved significantly and the complete blood count returned to normal, but the optimal ratio of BCR::ABL transcripts to ABL transcripts is greater than 10 % indicating treatment failure. Then we switched to a second generation TKIs to continue treatment, During the Flumatinib treatment period, the patient developed severe bone marrow suppression and exhibited additional cytogenetic abnormalities involving chromosome aberration: 47, XY,+8[5]/47, idem, inv(Y)(p11.2q11.23)[15]. By adjusting the drug dose and elevating blood cells, the patient’s BCR::ABL P210/ABL was 2.56 % after six months of Flumatinib treatment. The patient’s BCR::ABL P210/ABL consistently remained above 1 % throughout the treatment, and additional cytogenetic abnormalities were present. Next-generation sequencing revealed the recombination of exon 4 of the FBXO25 and exon 10 of the SEPT14, and this mutation has not been previously reported.

Conclusions
Our findings suggest that the FBXO25-SEPT14 fusion may be associated with tyrosine kinase inhibitors resistance in chronic myeloid leukemia.
On Class and Elitism in Archaeology
Authors: Ribeiro Artur , Giamakis Christos 
Published: September 2023

Abstract
While archaeology is certainly a politically conscious discipline, with various members involved in political and activist movements, especially focusing on gender and race issues, little has been said, discussed, or done with regards to class and elitism. In fact, it seems that since the advent of postmodernity in the 1970s, class and elitism have become moot topics. The aim of this article is to reflect upon class-based discrimination and elitism in archaeology, first by tracing the changes they have undergone, especially during late capitalist times, and how class has become sublimated to fit the neoliberal agenda; second, the article focuses on several issues concerning class and elitism in the university context in general, and in archaeology in particular, and how these serve as barriers to those less wealthy and fortunate; third, this work highlights how these issues concerning class and elitism in archaeology then affect scientific discourse on one hand, which has become more technologically advanced, and consequently more expensive, and archaeological theory on the other, which in its hectic search for novelty has lost its capacity to truly contribute anything new to our understanding of past and present societies.
Conceptualizations and evaluations of (im)politeness in Syrian Arabic
Authors: Hodeib Christina 
Published: September 2023

Abstract
This paper explores (im)politeness conceptualizations and evaluations and the moral foundations of lay notions of (im)politeness in Syrian Arabic. The data were collected using an online questionnaire which was administered to 88 native speaking participants. The results show that participants consider politeness and impoliteness as polar opposites; both are viewed as (in)consideration for others, chiefly conveyed through (dis)respect, and upholding/violating appropriate behaviors, respectively. Moreover, the results show that notions of hierarchical respect, face, equity rights, reciprocity, and attending to others’ needs are central in motivating participants’ views of (im)politeness. These notions are rooted in the moral foundations of authority/respect, fairness/reciprocity, and harm/care. Additionally, interesting findings emerge in that politeness in Syrian Arabic appears to be more of a relational phenomenon, based on morality, which is in line with contemporary views on politeness, than a rational and strategic behavior, as theorized in classical approaches.
From the source to the sea − A regional study of Bronze Age depositions from eastern Funen, Denmark
Authors: Frost Lise , Refshauge Beck Malene 
Published: September 2023

Abstract
Depositions from the South Scandinavian Bronze Age are traditionally associated with a landscape context that is restricted to division into field and bog finds. This obscures the important role of water as a location factor for depositions and the variation in the choice of deposition sites is not immediately clear. The starting point of the article is a period V multi-type deposition from Hedegyden near Nyborg, where an excavation has demonstrated that the deposition was placed at a spring. Together with more than 300 other Bronze Age depositions from the East Funen region in Denmark, relationships between the period’s depositions and the locations where they were placed in the landscape are examined chronologically and geographically, as well as within three partially overlapping water themes: in relation to springs – or places where water flows out, along watercourses and on the coast. In this study, especially the finds from springs should be highlighted, as a previously under-illuminated element of the Bronze Age wetland tradition.
A Final Bronze Age hoard from Cierpice, Poland: new evidence for the use and deposition of a horse bridle in the region
Authors: Gackowski Jacek , Kowalski Łukasz , Garbacz-Klempka Aldona , Rembisz-Lubiejewska Anna , Noryśkiewicz Agnieszka , Kamiński Dariusz , Podgórski Andrzej , Szczepańska Grażyna , Molewski Paweł , Sosnowski Mateusz , Kołyszko Marek , Kozicka Magdalena , Sokół Albin 
Published: September 2023

Zusammenfassung
Im Herbst 2020 entdeckte eine Gruppe von Detektorgängern auf einer bewaldeten Düne in der Nähe des Dorfes Cierpice in Nordzentralpolen 150 Bronzefunde. Der Fund umfasst Backenstücke, Phalerae, Rassel- und Terretringe sowie Zügelmanschetten mit Drahtgliedern, die einst Teil eines Pferdezaumzeugs aus der Endbronzezeit waren. Die Zaumzeugteile wurden zusammen mit einem Tüllenbeil in Pflanzenfasern eingewickelt und dann sorgfältig in einen organischen Beutel gelegt, der verrottet war. In diesem Artikel werden die Ergebnisse der archäologischen, metallographischen und paläobotanischen Untersuchungen des Hortes vorgestellt und diskutiert, unterstützt durch andere archäologisch dokumentierte Daten. Diese werden mit den Mustern der Bewegung und des Verbrauchs von Metallwaren im heutigen Polen während der Lausitzer Periode und dem weiteren Kontext der nordeuropäischen Bronzezeit in Beziehung gesetzt.
A new alkaloid from Portulaca oleracea L. with its anti-inflammatory activity
Authors: Yao Junjie , Wang Lina , Liu Peishan , Song Mingyang , Tian Jiayin , He Fan , Ying Xixiang 
Published: September 2023

Abstract
A new isoindole alkaloid, 6-hydroxy-2-(4′′′-hydroxy-3′′′-methoxyphenethyl)-4-(4′-hydroxy-3′-methoxyphenyl)-7-methoxy-1H-benzo[f]isoindole-1,3(2H)-dione, named oleraisoindole B was isolated from Portulaca oleracea L., its structure was elucidated using NMR and UHPLC-ESI-Q-TOF/MS spectroscopic methods, and presented anti-inflammatory activity at 5 μM.
Genetic Reduction of Insulin Signaling Mitigates Amyloid-β Deposition by Promoting Expression of Extracellular Matrix Proteins in the Brain
Authors: Sano Toshiharu , Ochiai Toshitaka , Nagayama Takeru , Nakamura Ayaka , Kubota Naoto , Kadowaki Takashi , Wakabayashi Tomoko , Iwatsubo Takeshi 
Published: September 2023

The insulin/IGF-1 signaling (IIS) regulates a wide range of biological processes, including aging and lifespan, and has also been implicated in the pathogenesis of Alzheimer's disease (AD). We and others have reported that reduced signaling by genetic ablation of the molecules involved in IIS (e.g., insulin receptor substrate 2 [IRS-2]) markedly mitigates amyloid plaque formation in the brains of mouse models of AD, although the molecular underpinnings of the amelioration remain unsolved. Here, we revealed, by a transcriptomic analysis of the male murine cerebral cortices, that the expression of genes encoding extracellular matrix (ECM) was significantly upregulated by the loss of IRS-2. Insulin signaling activity negatively regulated the phosphorylation of Smad2 and Smad3 in the brain, and suppressed TGF-β/Smad-dependent expression of a subset of ECM genes in brain-derived cells. The ECM proteins inhibited Aβ fibril formationin vitro, and IRS-2 deficiency suppressed the aggregation process of Aβ in the brains of male APP transgenic mice as revealed by injection of aggregation seedsin vivo. Our results propose a novel mechanism in AD pathophysiology whereby IIS modifies Aβ aggregation and amyloid pathology by altering the expression of ECM genes in the brain.SIGNIFICANCE STATEMENTThe insulin/IGF-1 signaling (IIS) has been recognized as a regulator of aging, a leading risk factor for the onset of Alzheimer's disease (AD). In AD mouse models, genetic deletion of key IIS molecules markedly reduces the amyloid plaque formation in the brain, although the molecular underpinnings of this amelioration remain elusive. We found that the deficiency of insulin receptor substrate 2 leads to an increase in the expression of various extracellular matrices (ECMs) in the brain, potentially through TGF-β/Smad signaling. Furthermore, some of those ECMs exhibited the potential to inhibit amyloid plaque accumulation by disrupting the formation of Aβ fibrils. This study presents a novel mechanism by which IIS regulates Aβ accumulation, which may involve altered brain ECM expression.
Layer 5 Intratelencephalic Neurons in the Motor Cortex Stably Encode Skilled Movement
Authors: Shinotsuka Takanori , Tanaka Yasuhiro R. , Terada Shin-Ichiro , Hatano Natsuki , Matsuzaki Masanori 
Published: September 2023

The primary motor cortex (M1) and the dorsal striatum play a critical role in motor learning and the retention of learned behaviors. Motor representations of corticostriatal ensembles emerge during motor learning. In the coordinated reorganization of M1 and the dorsal striatum for motor learning, layer 5a (L5a) which connects M1 to the ipsilateral and contralateral dorsal striatum, should be a key layer. Although M1 L5a neurons represent movement-related activity in the late stage of learning, it is unclear whether the activity is retained as a memory engram. Here, usingTlx3-Cremale transgenic mice, we conducted two-photon calcium imaging of striatum-projecting L5a intratelencephalic (IT) neurons in forelimb M1 during late sessions of a self-initiated lever-pull task and in sessions after 6 d of nontraining following the late sessions. We found that trained male animals exhibited stable motor performance before and after the nontraining days. At the same time, we found that M1 L5a IT neurons strongly represented the well-learned forelimb movement but not uninstructed orofacial movements. A subset of M1 L5a IT neurons consistently coded the well-learned forelimb movement before and after the nontraining days. Inactivation of M1 IT neurons after learning impaired task performance when the lever was made heavier or when the target range of the pull distance was narrowed. These results suggest that a subset of M1 L5a IT neurons continuously represent skilled movement after learning and serve to fine-tune the kinematics of well-learned movement.SIGNIFICANCE STATEMENTMotor memory persists even when it is not used for a while. IT neurons in L5a of the M1 gradually come to represent skilled forelimb movements during motor learning. However, it remains to be determined whether these changes persist over a long period and how these neurons contribute to skilled movements. Here, we show that a subset of M1 L5a IT neurons retain information for skilled forelimb movements even after nontraining days. Furthermore, suppressing the activity of these neurons during skilled forelimb movements impaired behavioral stability and adaptability. Our results suggest the importance of M1 L5a IT neurons for tuning skilled forelimb movements over a long period.
Regulation of NLGN3 and the Synaptic Rho-GEF Signaling Pathway by CDK5
Authors: Jeong Jaehoon , Han Wenyan , Hong Eunhye , Pandey Saurabh , Li Yan , Lu Wei , Roche Katherine W. 
Published: September 2023

Neuroligins (NLGNs) are postsynaptic cell adhesion molecules that are involved in synapse assembly and function. The NLGN gene family consists of 5 genes (NLGN1-3,4X, and4Y). NLGN3 forms heterodimers with other NLGNs and is expressed at both excitatory and inhibitory synapses, although the distinct role at different synapses is not fully understood. Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine/threonine kinase that targets various neuronal substrates to impact neuronal migration, neurite outgrowth, synaptic transmission, and plasticity. Both NLGNs and their presynaptic binding partners neurexins are highly associated with neurodevelopmental disorders. The NLGN3 gene is on the X chromosome and variants in NLGN3 have been linked to the pathophysiology in neurodevelopmental disorders. To better understand the endogenous modulation of NLGN3, we generated an HA-tagged knock-in mouse. We found that Cdk5 associates with NLGN3in vivoand phosphorylates NLGN3 on serine 725 (S725) in the knock-in mouse of either sex. The phosphorylation affects the NLGN3 association with Kalirin-7, a postsynaptic guanine nucleotide exchange factors for Rho GTPase family proteins. We further observed that the phosphorylation modulates NLGN3 surface expression and NLGN3-mediated synaptic currents in cultured rat neurons. Thus, we characterized NLGN3 as a novel Cdk5 substrate and revealed the functional consequences of NLGN3 S725 phosphorylation in neurons. Our study provides a novel molecular mechanism underlying Cdk5-mediated regulation of postsynaptic cell adhesion molecules.SIGNIFICANCE STATEMENTNLGN3 is involved in synapse assembly and function at both excitatory and inhibitory synapses and has been associated with the pathophysiology of neurodevelopmental disorders. Cdk5 has brain-specific activity and is involved in neuronal transmission, synapse function, and plasticity. Here, we characterize NLGN3 as a Cdk5 substrate for the first time and show that Cdk5-mediated phosphorylation regulates NLGN3 function. We demonstrate that NLGN3 S725 is a Cdk5 phosphorylation site, and reveal that the site is important for NLGN3 association with Kalirin-7, NLGN3 surface expression, and NLGN3-mediated synaptic transmission.
Involucramiento de las Estudiantes y los Estudiantes en el Proceso Educativo
Authors: Arguedas Negrini Irma 
Published: September 2023

En este trabajo se expone lo que es el involucramiento en el proceso educativo y su relación con la permanencia en secundaria y el bienestar de la población adolescente. Se describen los tres tipos de involucramiento que se han identificado (conductual, emocional y cognitivo) y las condiciones contextuales para favorecerlos. Se especifican factores institucionales y prácticas educativas que promueven el involucramiento, enfatizando en la importancia de la transmisión de altas expectativas acompañadas de los apoyos requeridos para el logro de las metas de la totalidad del estudiantado.Descriptores: involucramiento, permanencia en secundaria, desarrollo saludable, igualdad de oportunidades, adolescencia. Male and Female Student Involvement in the Educative ProcessThis paper discusses student engagement and how it relates to school completion and adolescents’ well-being. Three types of student engagement (behavioral, emotional, and cognitive) are described, as well as the environmental conditions that promote them. School factors and educational practices that favor engagement are mentioned, emphasizing on the importance of high expectations accompanied by the supports needed for goal attainment of all students.Keywords: Engagement, school completion, healthy development, equal opportunities, adolescence.