bluuebunny/crossref_metadata_2025_split huggingface dataset:
Flares in Lupus Nephritis: Risk Factors and Strategies for Their Prevention
Authors: Banos Aggelos , Bertsias George 
Published: July 2023

AbstractPurpose of ReviewDiscuss the prognostic significance of kidney flares in patients with lupus nephritis, associated risk factors, and possible preventative strategies.Recent FindingsRecently performed clinical trials and observational cohort studies underscore the high frequency of relapses of kidney disease, following initial response, in patients with proliferative and/or membranous lupus nephritis. Analysis of hard disease outcomes such as progression to chronic kidney disease or end-stage kidney disease, coupled with histological findings from repeat kidney biopsy studies, have drawn attention to the importance of renal function preservation that should be pursued as early as lupus nephritis is diagnosed. In this respect, non-randomized and randomized evidence have suggested a number of factors associated with reduced risk of renal flares such as attaining a very low level of proteinuria (< 700–800 mg/24 h by 12 months), using mycophenolate over azathioprine, adding belimumab to standard therapy, maintaining immunosuppressive/biological treatment for at least 3 to 5 years, and using hydroxychloroquine. Other factors that warrant further clarification include serological activity and the use of repeat kidney biopsy to guide the intensity and duration of treatment in selected cases.SummaryThe results from ongoing innovative studies integrating kidney histological and clinical outcomes, together with an expanding spectrum of therapies in lupus nephritis, are expected to facilitate individual medical care and long-term disease and patient prognosis.
Effect of Household Cooking Treatments on the Stability of β-glucans, Ergosterol, and Phenolic Compounds in White-Button (Agaricus bisporus) and Shiitake (Lentinula edodes) Mushrooms
Authors: Morales Diego , Bal Monika Anna , Figueredo Sara , Soler-Rivas Cristina , Ruiz-Rodríguez Alejandro 
Published: July 2023

AbstractWhite-button (Agaricus bisporus) and shiitake (Lentinula edodes) mushrooms are widely consumed worldwide because of their organoleptic properties but also their bioactive compounds such as β-glucans, ergosterol, and phenolic compounds. Although these mushrooms can be eaten as raw food, they are usually subjected to household cooking treatments, so their effect on the stability of these molecules was evaluated in this work. The results showed that frying reduced β-glucan and ergosterol content but protected mushrooms from the loss of phenolic compounds that were mainly affected by boiling, being this procedure able to increase β-glucans and ergosterol concentrations. It can be concluded that culinary treatments had differential effects depending on the specific molecule, so they should be applied or avoided considering the target compound. Moreover, further research is encouraged to fully understand the mechanisms involved in the content variations and the impact on the biological activity of these mushrooms.
Improvement of Learning and Memory by Elevating Brain D-Aspartate in a Mouse Model of Fragile X Syndrome
Authors: Li Yu-Jiao , Zhang Kun , Sun Ting , Guo Yan-Yan , Yang Qi , Liu Shui-Bing , Wu Yu-Mei , Zhao Ming-Gao 
Published: July 2023

AbstractFragile X syndrome (FXS) is an inherited human mental retardation that arises from expansion of a CGG repeat in the Fmr1 gene, causing loss of the fragile X mental retardation protein (FMRP). It is reported that N-methyl-D-aspartate receptor (NMDAR)-mediated facilitation of long-term potentiation (LTP) and fear memory are impaired in Fmr1 knockout (KO) mice. In this study, biological, pharmacological, and electrophysiological techniques were performed to determine the roles of D-aspartate (D-Asp), a modulator of NMDAR, and its metabolizing enzyme D-aspartate oxidase (DDO) in Fmr1 KO mice. Levels of D-Asp were decreased in the medial prefrontal cortex (mPFC); however, the levels of its metabolizing enzyme DDO were increased. Electrophysiological recordings indicated that oral drinking of D-Asp recovered LTP induction in mPFC from Fmr1 KO mice. Moreover, chronic oral administration of D-Asp reversed behavioral deficits of cognition and locomotor coordination in Fmr1 KO mice. The therapeutic action of D-Asp was partially through regulating functions of NMDARs and mGluR5/mTOR/4E-BP signaling pathways. In conclusion, supplement of D-Asp may benefit for synaptic plasticity and behaviors in Fmr1 KO mice and offer a potential therapeutic strategy for FXS.
A Scenario-based optimization model to design a hub network for covid-19 medical equipment management
Authors: Rahimi Amir , Azadnia Amir Hossein , Aghdam Mohammad Molani , Harsej Fatemeh 
Published: July 2023

AbstractThe provision of medical equipment during pandemics is one of the most crucial issues to be dealt with by health managers. This issue has revealed itself in the context of the COVID-19 outbreak in many hospitals and medical centers. Excessive demand for ventilators has led to a shortage of this equipment in several medical centers. Therefore, planning to manage critical hospital equipment and transfer the equipment between different hospitals in the event of a pandemic can be used as a quick fix. In this paper, a multi-objective optimization model is proposed to deal with the problem of hub network design to manage the distribution of hospital equipment in the face of epidemic diseases such as Covid-19. The objective functions of the model include minimizing transfer costs, minimizing the destructive environmental effects of transportation, and minimizing the delivery time of equipment between hospitals. Since it is difficult to estimate the demand, especially in the conditions of disease outbreaks, this parameter is considered a scenario-based one under uncertain conditions. To evaluate the performance of the proposed model, a case study in the eastern region of Iran is investigated and sensitivity analysis is performed on the model outputs. The sensitivity of the model to changing the cost parameters related to building infrastructure between hubs and also vehicle capacity is analyzed too. The results revealed that the proposed model can produce justified and optimal global solutions and, therefore, can solve real-world problems.
Labyrinthine Bifurcation of the Facial Nerve
Authors: Saro-Buendía Miguel , Mellidez Acosta Raúl , Bancalari Díaz Catalina , Mazón Miguel , de Paula Vernetta Carlos , Armengot Carceller Miguel 
Published: July 2023

AbstractThe labyrinthine bifurcation of the facial nerve is extremely rare. Diverse congenital temporal bone anomalies usually coexist, and a detailed preoperative evaluation is needed to detect them. We report a case of labyrinthine bifurcation of the facial nerve detected on the preoperative evaluation of a patient with congenital aural atresia.
Adverse events of antibody–drug conjugates on the ocular surface in cancer therapy
Authors: Domínguez-Llamas Sandra , Caro-Magdaleno Manuel , Mataix-Albert Beatriz , Avilés-Prieto Javier , Romero-Barranca Isabel , Rodríguez-de-la-Rúa Enrique 
Published: July 2023

AbstractAntibody–drug conjugates consist of a monoclonal antibody attached to a cytotoxic therapeutic molecule by a connector. This association allows a highly specific therapy, which increases their effectiveness and decreases their potential toxicity. This new therapy emerged approximately 20 years ago; since then, numerous combinations have appeared in the field of treatment-related neoplasms as an alternative for patients who do not achieve good results with conventional treatment options. Adverse effects of these drugs on the ocular surface are frequent and varied. Their prevalence ranges from 20 to 90% depending on the drug and administration condition, probably due to multiple receptor-mediated factors or mechanisms not mediated by specific receptors, such as macropinocytosis. These adverse events can greatly limit patients’ comfort; thus, the objectives of this article were, in the first place, to compile the information currently available on different types of adverse effects of antibody–drug conjugates on the ocular surface, including pathophysiology, prevalence, and treatment, and in second place, to contribute to the correct identification and management of these events, which will result in a lower rate of cessation of treatment, which is necessary for the survival of candidate patients.
Personal integrity and faking in the workplace: when competition matters
Authors: Seitl Martin , Manuoglu Elif , Krám Tomáš 
Published: July 2023

AbstractDespite the fact that employee faking or intentional response distortion is a critical concern in many workplace processes, the antecedents of this behavior are poorly understood. Based on signaling theory describing faking behavior as a strategic adaptation to competitive signals, this study examines the influence of personal integrity and perceived competition on faking. An online between-subjects experiment was carried out on a sample of teachers from elementary schools in selected regions of the Czech Republic (N = 470). The experimental group was subjected to competition-inducing instructions during the administration of the Occupational Integrity Scale (OIS) and the Balanced Inventory of Desirable Responding (BIDR-CZ), as an indicator of faking (impression management). Findings provided support for the moderating role of perceived competition on the link between impression management and personal integrity. Those who scored lower in reliability and moral sense (factors of OIS) exposed to competition-inducing instructions scored significantly higher on impression management than respondents in the control group, supporting the critical role of competition manipulation against excessive score inflation. Findings suggested that if organizations are not sure of the level of integrity of employees, they should not utilize competitive cues since individuals with low integrity tend to fake their responses to increase the person-organization fit. The managerial implications of these findings were discussed.
Combination of transjugular intrahepatic portosystemic shunt and antegrade through-the-TIPS coil embolization for bleeding mixed-type ectopic ileal varices
Authors: Michielan Andrea , Vieceli Filippo , Pravadelli Cecilia , Moser Luisa , Agugiaro Flora , Luppi Giacomo , Gatti Francesco Lorenzo , Costa Lorenzo , Rozzanigo Umberto Maria 
Published: July 2023

AbstractA 61-year-old man with alcoholic cirrhosis and a history of severe cholecystitis leading to secondary thrombosis of the recanalized paraumbilical vein was admitted to our hospital for recurrent gastrointestinal bleeding and severe anemia. Capsule endoscopy and CT angiography detected profuse bleeding in the proximal ileum from ectopic ileal varices. Hepatic venous-portal gradient (HVPG) measurement was consistent with severe portal hypertension. Persistent bleeding despite transjugular intrahepatic portosystemic shunt (TIPS) placement required a combined approach with antegrade through-the-TIPS coil embolization of the ileal varices.
Status of the neonatal follow-up system in China: survey and analysis
Authors: Zhou Qi , Cao Yun , Zhang Lan , Erejep Nurya , Xiu Wen-Long , Shi Jing-Yun , Cheng Rui , Zhou Wen-Hao , Lee Shoo K. 
Published: July 2023

AbstractBackgroundThere is little information about neonatal follow-up programs (NFUPs) in China. This study aimed to conduct a survey of hospitals participating in the Chinese Neonatal Network (CHNN) to determine the status of NFUPs, including resources available, criteria for enrollment, neurodevelopmental assessments, and duration of follow-up.MethodsWe conducted a descriptive study using an online survey of all 72 hospitals participating in CHNN in 2020. The survey included 15 questions that were developed based on the current literature and investigators’ knowledge about follow-up practices in China.ResultsSixty-four (89%) of the 72 hospitals responded to the survey, with an even distribution of children’s (31%), maternity (33%) and general (36%) hospitals. All but one (98%) hospital had NFUPs, with 44 (70%) being established after 2010. Eligibility criteria for follow-up were variable, but common criteria included very preterm infants < 32 weeks or < 2000 g birth weight (100%), small for gestational age (97%), hypoxic ischemic encephalopathy (98%) and postsurgery (90%). The average follow-up rate was 70% (range: 7.5%–100%). Only 12% of hospitals followed up with patients for more than 24 months. There was significant variation in neurodevelopmental assessments, follow-up schedule, composition of staff, and clinic facilities and resources. None of the staff had received formal training, and only four hospitals had sent staff to foreign hospitals as observers.ConclusionsThere is significant variation in eligibility criteria, duration of follow-up, types of assessments, staffing, training and facilities available. Coordination and standardization are urgently needed.
Environmental insults and compensative responses: when microbiome meets cancer
Authors: Nagpal Sunil , Mande Sharmila S. 
Published: July 2023

AbstractTumor microenvironment has recently been ascribed a new hallmark—the polymorphic microbiome. Accumulating evidence regarding the tissue specific territories of tumor-microbiome have opened new and interesting avenues. A pertinent question is regarding the functional consequence of the interface between host-microbiome and cancer. Given microbial communities have predominantly been explored through an ecological perspective, it is important that the foundational aspects of ecological stress and the fight to ‘survive and thrive’ are accounted for tumor-micro(b)environment as well. Building on existing evidence and classical microbial ecology, here we attempt to characterize the ecological stresses and the compensative responses of the microorganisms inside the tumor microenvironment. What insults would microbes experience inside the cancer jungle? How would they respond to these insults? How the interplay of stress and microbial quest for survival would influence the fate of tumor? This work asks these questions and tries to describe this underdiscussed ecological interface of the tumor and its microbiota. It is hoped that a larger scientific thought on the importance of microbial competition sensing vis-à-vis tumor-microenvironment would be stimulated.
Granular biomass technology for providing drinking water: microbial versatility and nitrate performance in response to carbon source
Authors: Muñoz-Palazon Barbara , Rodriguez-Sanchez Alejandro , Gonzalez-Lopez Jesus , Rosa-Masegosa Aurora , Gorrasi Susana , Vilchez-Vargas Ramiro , Link Alexander , Gonzalez-Martinez Alejandro 
Published: July 2023

AbstractThe aerobic granular biomass technology was optimized for treating nitrate-polluted groundwater based on the biological denitrification processes in order to provide drinking water. Reactors inoculated with granular biomass were operated at progressively lower C/N rate using acetate and methanol to encourage heterotrophic denitrification, in order to meet the recommended requirements described by European Drinking Water Framework Directive. The granulation and long-term stability of granular biomass under low C/N were successful for all stages, demonstrated compactness of granules and absence of filamentous microorganisms. The nitrate removal was similar in methanol- and acetate-fed reactors, occurring in both cases nitrate removal ratios > 80%, and fact allows the selection of one of both depending groundwater polluted case. Also, feeding reactors with 2 C/N ratio showed nitrate removal values of ≥ 95%, treating highly polluted groundwater (100 mg·L−1). The microbial diversity was higher in the methanol-fed reactor with representative phylotypes as Flavobacterium, Cytophagaceae, NS9 marine group, while species richness was higher in the acetate-fed reactor, which was mainly represented by Flavobacterium genus. Statistical analyses revealed the higher resilience of bacterial population on granules fed with acetate, showing more resistance under drop C/N ratio. Oscillating pollution in groundwater during seasonal periods should be treated using acetate as carbon source for denitrification carried out by granular biomass, while stable pollution concentrations over time allow the use of methanol as a carbon source since the greater microbial diversity allows the elimination of other contaminants present in groundwater.
Experimental and modeling analysis on the performance of 2-mercaptobenzimidazole corrosion inhibitor in hydrochloric acid solution during acidizing in the petroleum industry
Authors: Khormali Azizollah , Ahmadi Soroush 
Published: July 2023

AbstractIn this work, the corrosion inhibition of carbon steel in 1 molar HCl solution was evaluated by experimental and modeling approaches using 2-mercaptobenzimidazole (2-MBI). To this end, an experimental design for the weight loss method using response surface methodology (RSM) was carried out and the corrosion rate (CR) and inhibition efficiency (IE) were determined. The study was completed at various values of temperature, exposure time, and inhibitor concentration to determine the optimal conditions for corrosion prevention. Using experimental data on the corrosion rate and inhibition efficiency of 2-MBI, new models were developed, the significance of which was tested using ANOVA-analysis of variance. The developed RSM-based CR and IE models were highly accurate and reliable, and their P-values were less than 0.0001. The novelty of this study lies in the newly developed model for the evaluation of 2-MBI inhibition performance and its application to high-temperature conditions in the petroleum industry. Besides, the R2-statistics (R2, adjusted-R2, and predicted-R2), adequate precision and diagnostic plots were used as main measures to verify the accuracy and adequacy of both CR and IE models. In addition, it was observed that inhibitor concentration had the most impact on both CR and IE models compared to other parameters due to its largest F-values (561.65 for CR and 535.56 for IE models). Moreover, the results indicated that adding 140–150 ppm of 2-MBI at low-level temperatures of 30–35 °C had the most interaction effect on the performance of the corrosion inhibition process. In this case, the CR was less than 0.9 mm/y and the IE more than 94%, even after a high exposure time of 105 h. Furthermore, numerical optimization of the corrosion inhibition process for 2-MBI showed that the optimum conditions for maximum IE and minimum CR were achieved at a concentration of 115 ppm, temperature of 30.7 °C, and exposure time of 60.4 h. Under these conditions, the efficiency and corrosion rate were 92.76% and 0.53 mm/y, respectively. Finally, the adsorption of 2-MBI on the sample surface was studied at various exposure times and temperatures. In all cases, the adsorption behavior obeyed the Langmuir isotherm. In this case, the Gibbs adsorption free energy varied from − 33 to − 37 kJ/mol, which reflects both physical and chemical adsorption of the corrosion inhibitor at all tested temperatures and test times.
Urethane dimethacrylate-based photopolymerizable resins for stereolithography 3D printing: A physicochemical characterisation and biocompatibility evaluation
Authors: Pitzanti Giulia , Mohylyuk Valentyn , Corduas Francesca , Byrne Niall M. , Coulter Jonathan A. , Lamprou Dimitrios A. 
Published: July 2023

AbstractVat photopolymerisation (VP) three-dimensional printing (3DP) has attracted great attention in many different fields, such as electronics, pharmaceuticals, biomedical devices and tissue engineering. Due to the low availability of biocompatible photocurable resins, its application in the healthcare sector is still limited. In this work, we formulate photocurable resins based on urethane dimethacrylate (UDMA) combined with three different difunctional methacrylic diluents named ethylene glycol dimethacrylate (EGDMA), di(ethylene glycol) dimethacrylate (DEGDMA) or tri(ethylene glycol) dimethacrylate (TEGDMA). The resins were tested for viscosity, thermal behaviour and printability. After printing, the 3D printed specimens were measured with a digital calliper in order to investigate their accuracy to the digital model and tested with FT-IR, TGA and DSC. Their mechanical properties, contact angle, water sorption and biocompatibility were also evaluated. The photopolymerizable formulations investigated in this work achieved promising properties so as to be suitable for tissue engineering and other biomedical applications.
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Green synthesis of SiO2 nanoparticles from Egyptian white sand using submerged and solid-state culture of fungi
Authors: Hasanien Yasmeen A. , Mosleh Mahmoud A. , Abdel-Razek Alaa S. , El-Sayyad Gharieb S. , El-Hakim Elham H. , Borai Emad H. 
Published: July 2023

Abstract
This work aims to successfully produce silica nanoparticles (SNPs) from Egyptian white sand using the fungal bioleaching process as a cost-effective and eco-friendly approach. The impact of fungus cultivation techniques (submerged culture SMC and solid-state culture SSC) on the characteristics of the produced SNPs has been investigated. In addition, the most promising fungal isolates for each culture method were selected and identified by morphological and molecular methods. The biosynthesized SNPs were fully characterized by DLS, FTIR, XRD, SEM, EDX, and HRTEM studies. DLS results showed that Aspergillus niger solid-state culture had developed SNPs with a mean particle size distribution of about 3.6 nm, whereas Penicillium crustosum submerged culture developed SNPs with 50.7 nm. SEM images revealed that the prepared SNPs under SMC and SSC have sphere-shaped particles with smooth surfaces and semi-homogeneous characteristics. Moreover, the HRTEM imaging confirmed the spherical shape with an average size of 3.5 and 28.8 nm for the nanosilica synthesized during solid-state and submerged culture, respectively. Based on the results, we recommended using SSC to produce silica nanoparticles from white sand with a small nano-size, high purity, and better economical production. The scientific advances focused on some particular fungi's capacity to manufacture SNPs with high purity, small size, and techniques that were both economical and environmentally beneficial.

Graphical Abstract