bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analisis Respons Stres Oksidatif, Antioksidan, dan Adaptasi Fisiologis Jaringan Otak Pasca Induksi Hipoksia Hipobarik Intermiten Pada Tikus Spraque Dowley
Authors: Wardaya Wardaya , Khoirunnisa Marjani , Sukmayadi Asep Edi 
Published: January 2023

Penurunan konsentrasi oksigen dapat terjadi pada kondisi fisiologis tubuh maupun patologis. Hipoksia merupakan salah satu faktor yang berkontribusi dalam patomekanisme serangan jantung, stroke, hipertensi pulmonal dan penyakit-penyakit lain yang dapat menyebabkan kematian. Dasar ilmiah dari latihan hipoksia hipobarik intermiten pada Hypobaric chamber training ini, terutama mengenai manfaatnya, hingga saat ini masih belum banyak dipublikasikan. Tujuan penelitian ini adalah untuk menganalisis respons stres oksidatif, antioksidan, dan adaptasi fisiologis jaringan otak pasca induksi hipoksia hipobarik intermiten pada tikus Spraque dowley. Penelitian ini merupakan penelitian eksperimental in vivo dengan menggunakan hewan coba. Kegiatan penelitian ini dilaksanakan selama 5 (lima) bulan yaitu mulai bulan Agustus sampai dengan Desember. Tempat kegiatan penelitian di
Laboratorium Aerofisiologi Lakespra Saryanto dan Laboratorium Biokimia Biomolekuler FKUI Salemba. Penelitian yang telah dilakukan menunjukkan bahwa pada pemeriksaan kadar MDA pada otak tikus didapatkan hasil peningkatan kadar MDA pada kelompok hari ke-21 yaitu tikus yang mengalami tiga kali pemaparan hipoksia hipobarik walaupun tidak bermakna, sedangkan pada kelompok tikus yang mendapat paparan ulang hipoksia hipobarik (kelompok hari ke-7, 14 dan 28), didapatkan kadar MDA yang lebih rendah secara signifikan dibandingkan kontrol (p<0,005).
Perbandingan Metode Triase Modifikasi Empat Tingkat Dengan Triase Lima Tingkat Emergency Severity Index (ESI) Berdasarkan Tingkat Akurasi di RSUD Cibabat
Authors: Minggawati Zustantria Agustin , Faried Achmad , Priambodo Ayu Prawesti 
Published: January 2023

Keputusan triase harus tepat, akurat dan cepat karena akan mengancam keselamatan pasien. Sistem triase saat ini berbeda-beda. Sistem triase yang dianjurkan yaitu triase lima tingkat Emergency Severity Index (ESI) yang lebih akurat, mudah dipahami, mudah diaplikasi, mengurangi subjektifitas, dan sederhana dalam penggunaanya. RSUD Cibabat menggunakan triase empat tingkat modifikasi ATS yang belum dievaluasi tingkat keakuratannya. Tujuan penelitian ini yaitu mengetahui perbandingan metode triase empat tingkat modifikasi ATS dan metode triase lima tingkat ESI berdasarkan tingkat akurasi. Triase merupakan pemilahan, pengelompokkan pasien berdasarkan tingkat kegawatannya. Design penelitian yaitu cross over quasi eksperimental dengan 38 kegiatan triase baik kelompok kontrol dan kelompok intervensi dan 15 perawat yang melakukannya. Hasil penelitian menunjukkan bahwa triase ESI kategori expected triage 76,3%, under triase 13,2%, over triage 10,5%. Pada triase empat tingkat modifikasi ATS, expected triage 73,7 %, under triase 18,4%, over triage 7,9%. Hasil uji statistik, triase empat tingkat modifikasi ATS dengan triase lima tingkat ESI tidak terdapat perbedaan tingkat akurasi yang signifikan dengan nilai p-0,488. Namun jika ditelaah lebih lanjut ESI lebih akurat dalam memberikan keputusan expected triage. Adapun saran diberikan kepada RSUD Cibabat, dapat menggunakan triase ESI sebagai alternatif pilihan pengkajian triase karena akurat, sederhana, mudah digunakan.
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No es oro todo lo que reluce: precariedad y sobrecualificación en el mercado de trabajo de los doctores
Authors: Pablo Hernando Susana 
Published: January 2023

Los doctores son considerados actores claves en la actual economía del conocimiento debido a que disponen de conocimientos altamente especializados y de competencias estratégicas que facilitan los procesos de transferencia de conocimiento entre las organizaciones de los sistemas de innovación. Sin embargo, algunos estudios alertan de las dificultades que experimentan los doctores de algunas áreas para acceder a puestos de trabajo permanentes acordes a su nivel de cualificación y a sus expectativas salariales.
El objetivo de este trabajo es describir el mercado de trabajo de los doctores en España, para determinar el alcance de los problemas de precariedad laboral y de sobrecualificación en cada área de conocimiento. Este trabajo analiza los datos de la Encuesta de Inserción Laboral de los Titulados Universitarios 2019 del Instituto Nacional de Estadística.
Los resultados muestran que el título de doctor no ofrece protección contra el problema de inestabilidad del mercado laboral español, especialmente en el área de ciencias. Este título tampoco constituye necesariamente un pasaporte de acceso a empleos cualificados.
On the issue of classification of inspection and search equipment
Authors: Baumtrog Viktor Etmontovich 
Published: January 2023

The subject of the study is the classification of inspection and search equipment. The object of research in the work is the tactical and technical characteristics of various samples of inspection and search equipment, the features of its design, the principles of operation of the devices. The paper discusses such classifiers as the type of the detected object, the design features of the product, the specifics of the impact on the surrounding space, the physical principle of operation. The author pays special attention to the search, formulation and discussion of classification features that allow us to fully characterize not only the purpose and design of a specific inspection or search technical means, but also the principle of operation, in order to form a single conceptual apparatus in the subject area. The main results of the study are a comprehensive consideration of the classification of inspection and search equipment, the formulation of the names of groups of inspection and search equipment, based on its principle of operation. Within the framework of individual groups, an additional division of equipment into subgroups is proposed, which allows even more accurately characterizing its capabilities. The novelty of the research also lies in the discussion of the advantages and disadvantages of classifying signs of inspection and search equipment, in the proposal of a classification scheme based on the physical principles of the devices. For a more complete understanding of the developed classification, the author provides examples of search and inspection devices of different types according to the developed criteria.
Multimodal brain age estimates relate to Alzheimer disease biomarkers and cognition in early stages: a cross-sectional observational study
Authors: Millar Peter R , Gordon Brian A , Luckett Patrick H , Benzinger Tammie LS , Cruchaga Carlos , Fagan Anne M , Hassenstab Jason J , Perrin Richard J , Schindler Suzanne E , Allegri Ricardo F , Day Gregory S , Farlow Martin R , Mori Hiroshi , Nübling Georg ,   The Dominantly Inherited Alzheimer Network, Bateman Randall J , Morris John C , Ances Beau M 
Published: January 2023

Background:Estimates of ‘brain-predicted age’ quantify apparent brain age compared to normative trajectories of neuroimaging features. The brain age gap (BAG) between predicted and chronological age is elevated in symptomatic Alzheimer disease (AD) but has not been well explored in presymptomatic AD. Prior studies have typically modeled BAG with structural MRI, but more recently other modalities, including functional connectivity (FC) and multimodal MRI, have been explored.Methods:We trained three models to predict age from FC, structural (S), or multimodal MRI (S+FC) in 390 amyloid-negative cognitively normal (CN/A−) participants (18–89 years old). In independent samples of 144 CN/A−, 154 CN/A+, and 154 cognitively impaired (CI; CDR > 0) participants, we tested relationships between BAG and AD biomarkers of amyloid and tau, as well as a global cognitive composite.Results:All models predicted age in the control training set, with the multimodal model outperforming the unimodal models. All three BAG estimates were significantly elevated in CI compared to controls. FC-BAG was significantly reduced in CN/A+ participants compared to CN/A−. In CI participants only, elevated S-BAG and S+FC BAG were associated with more advanced AD pathology and lower cognitive performance.Conclusions:Both FC-BAG and S-BAG are elevated in CI participants. However, FC and structural MRI also capture complementary signals. Specifically, FC-BAG may capture a unique biphasic response to presymptomatic AD pathology, while S-BAG may capture pathological progression and cognitive decline in the symptomatic stage. A multimodal age-prediction model improves sensitivity to healthy age differences.Funding:This work was supported by the National Institutes of Health (P01-AG026276, P01- AG03991, P30-AG066444, 5-R01-AG052550, 5-R01-AG057680, 1-R01-AG067505, 1S10RR022984-01A1, and U19-AG032438), the BrightFocus Foundation (A2022014F), and the Alzheimer’s Association (SG-20-690363-DIAN).
Depletion of PSMD14 suppresses bladder cancer proliferation by regulating GPX4
Authors: Jia Changxin , Zhang Xin , Qu Tingting , Wu Xiuyun , Li Yu , Zhao Yang , Sun Lijiang , Wang Qing 
Published: January 2023

Objective
The aim of this study was to investigate the role of deubiquitinase (DUB) 26S proteasome non-ATPase regulatory subunit 14 (PSMD14) in patients with bladder cancer.

Methods
From 2016 to 2018, 181 patients diagnosed with primary bladder cancer at the Affiliated Hospital of Qingdao University were recruited. The expression of PSMD14 in bladder cancer tissues was tested by immunochemistry. The association between PSMD14 expression and clinical and pathological data and outcomes of bladder cancer patients was determined. Overexpression and knockdown cells were constructed to evaluate the effects of PSMD14 on proliferation of bladder cancer cells.

Results
Our results showed that PSMD14 was significantly overexpressed in bladder cancer tissues compared to adjacent non-tumor tissues (76.24% vs 23.76%, P = 0.02). The expression of PSMD14 was significantly higher in patients with larger tumor diameters (85.14% vs 70.09%, P = 0.019) and patients with a family history of cancer (92.16% vs 70.00%, P = 0.002). Patients with high expression of PSMD14 had poor disease-free survival (DFS) (HR = 2.89, 95% CI [1.247–6.711], P = 0.013). Gain and loss of function experiments demonstrated that PSMD14 deficiency inhibited bladder cancer cell proliferation. Additionally, depletion of PSMD14 suppressed bladder cancer cell growth via down-regulation of GPX4, and the promotion of PSMD14-induced cell growth was observably reversed by the GPX4 inhibitor RSL3.

Conclusion
We determined that PSMD14 is highly expressed in bladder cancer tissues, and that PSMD14 expression correlated with poor disease-free survival. Depletion of PSMD14 could inhibit the proliferation of bladder cancer cells through the downregulation of GPX4. Therefore, PSMD14 may be an effective target for the treatment of bladder cancer.
A Comparative Study between Covid-19 Positive versus Suspected Patients: A Single-Center Study in Bangladesh
Authors: Hossain Monir , Ansari M. A. Jalil , Mollah Mujibul Haque , Msaum Md. , Islam Serajul 
Published: January 2023

Background: The novel coronavirus disease or Covid-19 was first identified in Wuhan, China, which quickly involved majority of the countries across the world. Because of its high rate of mortality-morbidity and the similarities in signs and symptoms of pneumonia, it is very important to acquire proper knowledge to differ Covid-19 suspected and positive cases.
Aim of the Study: The aim of this study was to compare the demographic and clinical findings between Covid-19 positive and suspected patients.
Methods: This comparative observational study was conducted in the Department of Medicine, Shahabuddin Medical College Hospital, Gulshan, Dhaka, Bangladesh, during the period from November 2020 to March 2022. In total 126 suspected Covid-19 patients were included as the study subjects for this study. After confirming 16 Covid-19 positive cases from total 126 participants by RT-PCR tests, the demographic and clinical features of those positive cases were compared with previously found findings (When total participants were defined as suspected) of total participants. A predesigned questioner was used in data collection. All data were collected, processed and analyzed by using MS Office and SPSS version 23 programs as per need.
Results: In this study, in comparing the demographic findings like age, gender as well as body-weights of Covid-19 suspected and positive group patients, we did not find any significant correlation. But in comparing the electrolytes: Na+, K+ and Cl- between the groups, we found extremely significant correlation between Covid-19 suspected and positive groups where the P values were found as <0.0001, 0.002 and 0.0002 respectively. In this study, as more frequent comorbidities, HTN and DM were observed in both the groups (>10%).
Conclusion: It is very difficult to confirm Covid-19 cases from suspected cases by demographic and/or clinical investigation without RT-PCR tests. Electrolyte assessment may play an important role in detecting Covid-19 cases.
Analysis of a Sabin-Strain Inactivated Poliovirus Vaccine Response to a Circulating Type 2 Vaccine-Derived Poliovirus Event in Sichuan Province, China 2019-2021
Authors: Yang Hong , Qi Qi , Zhang Yong , Wen Ning , Cao Lei , Liu Yu , Fan Chunxiang , Yan Dongmei , Zhu Xiaoping , Hao Lixin , Zhu Shuangli , Ma Qianli , Liu Jiajie , Ma Chao , Nan Lei , Chen Yong , Ma Xiaozhen , Chen Na , Deng Kun , Shao Ge , Ding Xianxiang , An Zhijie , Rodewald Lance E. , Li Xiaolei , Wang Dongyan , Zhu Hui , Wang Huaqing , Feng Zijian , Xu Wenbo , Zhou Jiushun , Yin Zundong ,   China cVDPV2 Response Experts Group, Yang Weizhong , Li Qun , Luo Huiming , Xu Aiqiang , Fang Fang 
Published: January 2023

ImportanceThe Sabin-strain inactivated poliovirus vaccine (IPV) may be a tool for polio outbreak response in certain situations.ObjectiveTo investigate the response to a type 2 vaccine-derived poliovirus (VDPV2) outbreak.Design, Setting, and ParticipantsThis case series was conducted in China after a VDPV2 was detected in stool specimens from a child with acute flaccid paralysis (AFP) in Sichuan Province in 2019, 3 years after the global withdrawal of live, attenuated type 2 oral poliovirus vaccine (OPV). Investigation followed National Health Commission and World Health Organization guidance and included searching hospitals for unreported AFP cases; testing stool specimens from the child, his contacts, and local children; enhanced environmental surveillance for VDPV2s in wastewater; and measuring vaccination coverage. Sabin-strain IPV campaigns were conducted in a wide geographic area.Main Outcomes and MeasuresAny VDPV2 detection after completion of the supplementary immunization activities.ResultsA 28-nucleotide-change VDPV2 was isolated from a young boy. Three VDPV2s were detected in healthy children; 2 were contacts of the original child, and none had paralysis. A search of 31 million hospital records found 10 unreported AFP cases; none were polio. No type 2 polioviruses were found in wastewater. Prior to the event, polio vaccine coverage was 65% among children younger than 5 years. Sabin-strain IPV campaigns reached more than 97% of targeted children, administering 1.4 million doses. No transmission source was identified. More than 1 year of enhanced poliovirus environmental and AFP surveillance detected no additional VDPVs.Conclusions and RelevanceThese findings suggest that the circulating VPDV2 outbreak in 2019 was associated with low vaccine coverage. An investigation discovered 3 infected but otherwise healthy children and no evidence of the virus in wastewater. Following Sabin-strain IPV–only campaigns expanding from county to prefecture, the poliovirus was not detected, and the outbreak response was considered by an expert panel and the World Health Organization to have been successful. This success suggests that the Sabin-strain IPV may be a useful tool for responding to circulating VDPV2 outbreaks when high-quality supplementary immunization activities can be conducted and carefully monitored in settings with good sanitation.
Femtosecond Laser 4D Printing of Light‐Driven Intelligent Micromachines
Authors: Deng Chunsan , Liu Yuncheng , Fan Xuhao , Jiao Binzhang , Zhang Zexu , Zhang Mingduo , Chen Fayu , Gao Hui , Deng Leimin , Xiong Wei 
Published: January 2023

AbstractIntelligent micromachines that respond to external light stimuli have a broad range of potential applications, such as microbots, biomedicine, and adaptive optics. However, artificial light‐driven intelligent micromachines with a low actuation threshold, rapid responsiveness, and designable and precise 3D transformation capability remain unachievable to date. Here, a single‐material and one‐step 4D printing strategy are proposed to enable the nanomanufacturing of agile and low‐threshold light‐driven 3D micromachines with programmable shape‐morphing characteristics. The as‐developed carbon nanotube‐doped composite hydrogel simultaneously enhanced the light absorption, thermal conductivity, and mechanical modulus of the crosslinked network, thus significantly increasing the light sensitivity and response speed of micromachines. Moreover, the structural design and assembly of asymmetric microscale mechanical metamaterial unit cells enable the highly efficient additive nanomanufacturing of 3D shape‐morphable micromachines with large dynamic modulation and spatiotemporal controllability. Using this strategy, the world's smallest artificial beating heart with programmable light‐stimulus responsiveness for the cardiac cycle is successfully printed. This 4D printing method paves the way for the construction of multifunctional intelligent micromachines for bionics, drug delivery, integrated microsystems, and other fields.
High‐Entropy Enhanced Microwave Attenuation in Titanate Perovskites
Authors: Zhao Biao , Yan Zhikai , Du Yiqian , Rao Longjun , Chen Guanyu , Wu Yuyang , Yang Liting , Zhang Jincang , Wu Limin , Zhang David Wei , Che Renchao 
Published: January 2023

AbstractHigh‐entropy oxides (HEOs), which incorporate multiple‐principal cations into single‐phase crystals and interact with diverse metal ions, extend the border for available compositions and unprecedented properties. Herein, a high‐entropy‐stabilized (Ca0.2Sr0.2Ba0.2La0.2Pb0.2)TiO3 perovskite is reported, and the effective absorption bandwidth (90% absorption) improves almost two times than that of BaTiO3. The results demonstrate that the regulation of entropy configuration can yield significant grain boundaries, oxygen defects, and an ultradense distorted lattice. These characteristics give rise to strong interfacial and defect‐induced polarizations, thus synergistically contributing to the dielectric attenuation performance. Moreover, the large strains derived from the strong lattice distortions in the high‐entropy perovskite offer varied transport for electron carriers. The high‐entropy‐enhanced positive/negative charges accumulation around grain boundaries and strain‐concentrated location, quantitatively validated by electron holography, results in unusual dielectric polarization loss. This study opens up an effective avenue for designing strong microwave absorption materials to satisfy the increasingly demanding requirements of advanced and integrated electronics. This work also offers a paradigm for improving other interesting properties for HEOs through entropy engineering.
Evaporated Self‐Assembled Monolayer Hole Transport Layers: Lossless Interfaces in p‐i‐n Perovskite Solar Cells
Authors: Farag Ahmed , Feeney Thomas , Hossain Ihteaz M. , Schackmar Fabian , Fassl Paul , Küster Kathrin , Bäuerle Rainer , Ruiz‐Preciado Marco A. , Hentschel Mario , Ritzer David B. , Diercks Alexander , Li Yang , Nejand Bahram Abdollahi , Laufer Felix , Singh Roja , Starke Ulrich , Paetzold Ulrich W. 
Published: January 2023

AbstractEngineering of the interface between perovskite absorber thin films and charge transport layers has fueled the development of perovskite solar cells (PSCs) over the past decade. For p‐i‐n PSCs, the development and adoption of hole transport layers utilizing self‐assembled monolayers (SAM‐HTLs) based on carbazole functional groups with phosphonic acid anchoring groups has enabled almost lossless contacts, minimizing interfacial recombination to advance power conversion efficiency in single‐junction and tandem solar cells. However, so far these materials have been deposited exclusively via solution‐based methods. Here, for the first time, vacuum‐based evaporation of the most common carbazole‐based SAM‐HTLs (2PACz, MeO‐2PACz, and Me‐4PACz) is reported. X‐ray photoelectron spectroscopy and infrared spectroscopy demonstrate no observable chemical differences in the evaporated SAMs compared to solution‐processed counterparts. Consequently, the near lossless interfacial properties are either preserved or even slightly improved as demonstrated via photoluminescence measurements and an enhancement in open‐circuit voltage. Strikingly, applying evaporated SAM‐HTLs to complete PSCs demonstrates comparable performance to their solution‐processed counterparts. Furthermore, vacuum deposition is found to improve perovskite wetting and fabrication yield on previously non‐ideal materials (namely Me‐4PACz) and to display conformal and high‐quality coating of micrometer‐sized textured surfaces, improving the versatility of these materials without sacrificing their beneficial properties.
Chronic myeloid leukemia without major molecular response after 2 years of treatment with tyrosine kinase inhibitor
Authors: Bidikian Aram , Jabbour Elias , Issa Ghayas C. , Short Nicholas J. , Sasaki Koji , Kantarjian Hagop 
Published: January 2023

AbstractAchieving major molecular response (MMR) with BCR::ABL1 tyrosine kinase inhibitors (TKIs) is associated with lower chances of progression to advanced phase disease and higher chances of treatment‐free remission (TFR) in patients with chronic myeloid leukemia (CML). Failure to achieve this molecular milestone after 1 year has been highlighted as “suboptimal” or “warning” sign of treatment failure in CML guidelines and recommendations and implied to predict a poor long‐term outcome. In this analysis, we report the long‐term outcome of 131 patients who did not achieve MMR within the first 2 years of TKI therapy. Patients who achieved a major cytogenetic response (MCyR; roughly equivalent to BCR::ABL1 transcript levels on the International Scale [IS] <10%) had good long‐term overall survival (OS) (10‐year OS of 88%) and CML‐related overall survival (CML‐OS) (10‐year CML‐OS of 95%). The achievement of MCyR within the first 2 years of treatment predicted a better OS (HR = 0.43, p = .03). The value of MMR was even less pronounced among patients aged 60 years or older at diagnosis, in whom mortality was primarily due to comorbidities unrelated to CML (10‐year OS of 55% vs. 10‐year CML‐OS of 100%). In conclusion, achievement of MCyR within 2 years is a reasonable milestone in CML, and these patients can still have good outcomes even when MMR is not achieved.