bluuebunny/crossref_metadata_2025_split huggingface dataset:
Encouraging brisk walking with the free Active10 app in postnatal women who had a hypertensive pregnancy: “Just Walk It” feasibility study
Authors: Razai Mohammad S. , Trinder Bonnie , Perry Alice , Cauldwell Matthew , Reid Fiona , Oakeshott Pippa 
Published: February 2023

Objective
To explore the feasibility of a future trial to investigate whether encouraging use of the free NHS smartphone app Active10 increases brisk walking and reduces blood pressure (BP) in postnatal mothers who had hypertensive disorders of pregnancy (HDP).

Design
3-month feasibility study.

Setting
London maternity unit.

Population
21 women with HDP.

Methods
At recruitment we recorded initial (booking) clinic BP and asked participants to complete a questionnaire. Two months after delivery all participants were sent (by post/email/WhatsApp) a “Just Walk It” leaflet encouraging them to download the Active10 app and walk briskly for at least 10 minutes/day. This was backed by a telephone call after 2-weeks. Assessments were repeated 3-months later, and included telephone interviews about the acceptability and use of Active10.

Main outcome measures
Were recruitment rate, follow-up rate and acceptability/use of Active10.

Results
Of 28 women approached, 21 (75%, 95% CI 55.1–89.3%) agreed to participate. Age range was 21–46 years and five (24%) self-identified as black ethnicity. One woman dropped out of the study, and one became ill. The remaining participants (90%, 19/21, 95% CI 69.6–98.8%) were followed up after 3-months. Ninety-five percent (18/19) downloaded the Active10 app and 74% (14/19) continued using it at 3-months, averaging 27-minutes brisk walking/day according to Active10 weekly screenshots. Comments included: “Brilliant app”, “Really motivates me”. Mean BP was 130/81mmHg at booking and 124/80mmHg at 3-months follow-up.

Conclusions
The Active10 app was acceptable to postnatal women after HDP and may have increased minutes of brisk walking. A future trial could explore whether this simple, low-cost intervention could reduce long-term BP in this vulnerable group.
Cholangioscope-Guided Electrohydraulic Lithotripsy as a Rescue Technique for an Impacted Dormia Basket With Large Common Bile Duct Stone
Authors: Syed Imran Ali , Hanif Muhammad Farooq , Malik Ahmad Karim , Aujla Usman Iqbal 
Published: February 2023

ABSTRACT
Impaction of Dormia basket while extracting common bile duct (CBD) stones during endoscopic retrograde cholangiopancreatography is a well-known but relatively rare complication. Its management could be very challenging and may require percutaneous, endoscopic, or major surgical intervention. In this study, we present a case of a 65-year-old man with a history of obstructive jaundice secondary to a large CBD stone. For stone extraction, mechanical lithotripsy with a Dormia basket was attempted resulting in its entrapment within CBD. Subsequently, the entrapped basket and large stone were retrieved using a novel technique of cholangioscope-guided electrohydraulic lithotripsy with excellent clinical outcomes.
Chronic Inflammatory Demyelinating Polyneuropathy After Therapy With Infliximab Biosimilar
Authors: Larson Jessica , Twohig Patrick , Hutchins Kathryn 
Published: February 2023

ABSTRACT
Tumor necrosis factor-α inhibitors are monoclonal antibodies that are commonly used in the treatment of inflammatory bowel disease. A rare side effect of these biological agents is chronic inflammatory demyelinating polyneuropathy, which is a debilitating disease characterized by weakness, sensory dysfunction, and diminished or absent reflexes. We present the first reported case of chronic inflammatory demyelinating polyneuropathy after treatment with the tumor necrosis factor-α inhibitor biosimilar, infliximab-dyyp (Inflectra).
Implementation of the Congklak Traditional Game in Madrasah Ibtidaiyah and Elementary School
Authors: Yantoro Yantoro , Kurniawan Dwi Agus , Silvia Ninda 
Published: February 2023

This study aims to find out how the response and character of the curiosity and love for the homeland of students in SD and MI with the application of the traditional game Congklak in the learning process. The research method used was a mixed method with a sequential explanatory model, with a sample of 60 students from both schools obtained by random sampling. Researchers used questionnaires to collect data and interviews as support. The data analysis used is descriptive analysis and hypothesis testing using the T-test. From the application of the traditional game of congklak, significant results are obtained that there are differences in the results of SD Negeri and MI Negeri. However, the response as well as the students' curiosity and love for the homeland from the application of the traditional game of congklak were in the good category.
Studying the effect of embedded length strength of concrete and diameter of anchor on shear performance between old and new concrete
Authors: Yousef Rana F. , Muteb Haitham H. , Ibrahim Ayoob A. 
Published: February 2023

Abstract
This article illustrates the specifications required to accurately design, specify, and install embedded anchor bolts between old and new concrete composite specimens for concrete repair or reinforcing of collapse concrete a research hotspot. The concrete slabs are facing a major challenge with deterioration, especially for reinforcement corrosion caused mainly by severe cycles of various chemical attacks. In this research, the impact of using contact plates between composite specimens was investigated by testing grouped specimens, thereby the models were divided into two groups, which tested under static load. The findings of a series of tests conducted to evaluate the structural behavior of shear connections (by pushout test) by including many parameters; the diameter (8, 12 and 16 mm), bounding between different compressive strength should be changed [normal concert (NC) mixes , ultra-high performance fiber concrete (UHPFC), and self-compacting mortar (SCM)]. Also, the embedded length of bolts was varied from 70, 130, to 190 mm. These parameters were studied individually in two groups. The first group was without contact plate and the second group was with contact plate. Experimental findings were obtained and reported, including the failure modes, maximum resistance, slippage capacity, and load–slip characteristic responses of the connections. Based on the obtained data, a relationship between the studied parameters was investigated. Experimental findings showed that the ultimate strength of rough surface specimens (without contact plate) was about 31% greater than that of smooth surface specimens (with contact plate), and obviously, all pushout specimens failed due to stud shank failure.
The second PI(3,5)P2 binding site in the S0 helix of KCNQ1 stabilizes PIP2-at the primary PI1 site with potential consequences on intermediate-to-open state transition
Authors: Dellin Maurice , Rohrbeck Ina , Asrani Purva , Schreiber Julian A. , Ritter Nadine , Glorius Frank , Wünsch Bernhard , Budde Thomas , Temme Louisa , Strünker Timo , Stallmeyer Birgit , Tüttelmann Frank , Meuth Sven G. , Spehr Marc , Matschke Johann , Steinbicker Andrea , Gatsogiannis Christos , Stoll Raphael , Strutz-Seebohm Nathalie , Seebohm Guiscard 
Published: February 2023

Abstract
The Phosphatidylinositol 3-phosphate 5-kinase Type III PIKfyve is the main source for selectively generated phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2), a known regulator of membrane protein trafficking. PI(3,5)P2 facilitates the cardiac KCNQ1/KCNE1 channel plasma membrane abundance and therewith increases the macroscopic current amplitude. Functional-physical interaction of PI(3,5)P2 with membrane proteins and its structural impact is not sufficiently understood. This study aimed to identify molecular interaction sites and stimulatory mechanisms of the KCNQ1/KCNE1 channel via the PIKfyve-PI(3,5)P2 axis. Mutational scanning at the intracellular membrane leaflet and nuclear magnetic resonance (NMR) spectroscopy identified two PI(3,5)P2 binding sites, the known PIP2 site PS1 and the newly identified N-terminal α–helix S0 as relevant for functional PIKfyve effects. Cd2+ coordination to engineered cysteines and molecular modeling suggest that repositioning of S0 stabilizes the channel s open state, an effect strictly dependent on parallel binding of PI(3,5)P2 to both sites.
A comparative study on structural, magnetic and optical properties of rare earth ions substituted Bi1−x

R

x
FeO3 (R: Ce3+, Sm3+ and Dy3+) nanoparticles
Authors: Kumar Manoj 
Published: February 2023

Abstract
A comparative study on the manifestation of rare earth ions substitution induced alteration in structure, magnetic and optical properties of BiFeO3 nanoparticles was done. Sol-gel technique was employed to synthesize Bi1−x

R

x
FeO3 (x = 0.05 and 0.10; R: Ce3+, Sm3+ and Dy3+) nanoparticles. X-ray diffraction patterns and Raman spectra analysis confirmed substitution driven structural phase transformation from distorted rhombohedral structure to orthorhombic structure for x = 0.10 samples. The enhanced magnetic properties with weak ferromagnetic behaviour were observed with increasing concentration of rare earth ions in BiFeO3 nanoparticles. The improved magnetic characteristics are attributed to many factors such as the uncompensated surface spins in nanoparticles, breaking of spin cycloid with R
3+ ions substitution and super exchange interaction between R
3+ and Fe3+ ions. The maximum magnetization values of 1.77 emu g−1, 1.87 emu g−1 and 5.5 emu g−1 were observed for x = 0.10 samples with Ce3+, Sm3+ and Dy3+ substitution, respectively. The magnetization increased with increasing difference in ionic radii of host Bi3+ (1.17 Å) ion and dopant Ce3+ (1.14 Å), Sm3+ (1.08 Å) and Dy3+ (1.03 Å) ions. UV–Visible diffuse reflectance spectra showed a sharp absorption in visible region and energy band gap values variation in the range 2.2 eV–2.33 eV.
Improving mechanical properties of additive manufactured AZ31 by mechanical rolling
Authors: Veerasamy Senthilvelan , Sankaran Rameshbabu , Sutrave Atul C. 
Published: February 2023

Abstract
The mechanical performance of AZ31, a popular aerospace structural material, manufactured using CMT-WAAM was studied in this paper. A wall of 70 × 200 × 4 mm was built by layer-by-layer deposition of 4 mm thick beads. The influence of rolling along the direction of welding on hardness, tensile strength and residual stress was investigated and compared with the control build fabricated using “synergic” parameters recommended by Fronius, Austria. The specimens extracted from the AM (Additive Manufacturing) built walls were subjected to cross-section reduction up to 22.5% compared to control specimens. The rolled specimens displayed up to 10% increase in the tensile strength values compared to control specimens and a generally lower elongation value. A similar trend was observed in the hardness examination as well. A peak hardness of 77 HV0.5 was observed in the specimen subjected to 22.17% reduction. The rolled samples exhibit a 14.32% reduction in residual stresses.
Spin-controlled photonics via temporal anisotropy
Authors: Rizza Carlo , Castaldi Giuseppe , Galdi Vincenzo 
Published: February 2023

Abstract
Temporal metamaterials, based on time-varying constitutive properties, offer new exciting possibilities for advanced field manipulations. In this study, we explore the capabilities of anisotropic temporal slabs, which rely on abrupt changes in time from isotropic to anisotropic response (and vice versa). Our findings show that these platforms can effectively manipulate the wave-spin dimension, allowing for a range of intriguing spin-controlled photonic operations. We demonstrate these capabilities through examples of spin-dependent analog computing and spin–orbit interaction effects for vortex generation. These results provide new insights into the field of temporal metamaterials, and suggest potential applications in communications, optical processing and quantum technologies.
Network meta-analysis on alcohol-mediated modulation of Alzheimer’s disease in the diseases of inflammation including COVID-19
Authors: Bishir Muhammed , Rengifo Tatiana , Huang Wenfei , Kim Ryan J. , Chidambaram Saravana Babu , Chang Sulie L. 
Published: February 2023

Abstract

Objectives
Cross sectional surveys have reported that alcohol consumption has skyrocketed during the COVID-19 pandemic. Chronic alcohol use triggers systemic inflammation which leads to neuroinflammation and neurodegeneration. In the present study, we hypothesize that alcohol consumption and cytokine elevation during inflammatory conditions synergistically increase amyloid-beta precursor protein (APP) expression and worsens Alzheimer’s disease (AD) pathology.

Methods
QIAGEN Ingenuity Pathway Analysis (IPA) was employed to conduct network meta-analysis on the molecular mechanisms underlying ethanol (EtOH) influence on APP expression and AD in inflammatory conditions including COVID-19, inflammation of respiratory system, organ, absolute anatomical region, body cavity, joint, respiratory system component, gastrointestinal tract, large intestine, liver, central nerve system, and lung. IPA tools were utilized to identify the molecules associated with EtOH, inflammatory conditions and the common molecules between them.

Results
Simulation activity of EtOH, mimicking exposure to alcohol, upregulated the APP expression and augmented AD pathology in all inflammatory conditions including COVID-19. Our studies identified six molecules including ADORA2A, Cytokine, IFN-gamma, IL1-beta, Immunoglobulin and TNF, which concurrently contribute to increased APP expression and AD progression upon EtOH simulation in all diseases studied.

Conclusions
The present study has revealed molecular mechanisms underlying alcohol augmentation of AD in COVID-19 and other diseases of inflammation.
Deceiving oneself into faith?
Authors: Neuber Simone 
Published: February 2023

Abstract
“Follow the way by which they began; by acting as if they believed, taking the holy water, having masses said, etc.” The well-known lines from Pascal’s much-discussed fragment “infini rien” have been much commented on. In this context, the keyword self-deception comes up surprisingly often, partly as a criticism of Pascal’s presumed strategy, partly in an attempt to make these lines fruitful for the current discussion on self-deception. I remind the latter attempts to consider an important condition for the success of the “regimen”, which becomes clear when one reflects on the internal characterisation of Pascal’s interlocutor. For if we take into account the kind of self-knowledge we must ascribe to her, we cannot regard her as someone whom acting-as-if naturally leads to faith, but as someone who has already been touched by the grace of God.
The emergence of monumental architecture in Atlantic Europe: a fortified fifth-millennium BC enclosure in western France
Authors: Ard Vincent , Onfray Marylise , Aoustin David , Bouchet Éric , Bruniaux Guillaume , Dandurand Grégory , Daniel François , Dufraisse Alexa , Granai Salomé , Laurent Antoine , Legrand Victor , Lévêque François , Lüth Friedrich , Mathé Vivien , Mora Pascal , Vitté Hélène 
Published: February 2023

AbstractThe earliest monumentality in Western Europe is associated with megalithic structures, but where did the builders of these monuments live? Here, the authors focus on west-central France, one of the earliest centres of megalithic building in Atlantic Europe, commencing in the mid fifth millennium BC. They report on an enclosure at Le Peu (Charente), dated to the Middle Neolithic (c. 4400 BC), and defined by a ditch with two ‘crab claw’ entrances and a double timber palisade flanked by two timber structures—possibly defensive bastions. Inside, timber buildings—currently the earliest known in the region—were possibly home to the builders of the nearby Tusson long mounds.
Neuro-Immune Modulation of Cholinergic Signaling in an Addiction Vulnerability Trait
Authors: Carmon Hanna , Haley Evan C. , Parikh Vinay , Tronson Natalie C. , Sarter Martin 
Published: February 2023

AbstractSign-tracking (ST) describes the propensity to approach and contact a Pavlovian reward cue. By contrast, goal-trackers (GTs) respond to such a cue by retrieving the reward. These behaviors index the presence of opponent cognitive-motivational traits, with STs exhibiting attentional control deficits, behavior dominated by incentive motivational processes, and vulnerability for addictive drug taking. Attentional control deficits in STs were previously attributed to attenuated cholinergic signaling, resulting from deficient translocation of intracellular choline transporters (CHTs) into synaptosomal plasma membrane. Here, we investigated a posttranslational modification of CHTs, poly-ubiquitination, and tested the hypothesis that elevated cytokine signaling in STs contributes to CHT modification. We demonstrated that intracellular CHTs, but not plasma membrane CHTs, are highly ubiquitinated in male and female sign-tracking rats when compared with GTs. Moreover, levels of cytokines measured in cortex and striatum, but not spleen, were higher in STs than in GTs. Activation of the innate immune system by systemic administration of the bacterial endotoxin lipopolysaccharide (LPS) elevated ubiquitinated CHT levels in cortex and striatum of GTs only, suggesting ceiling effects in STs. In spleen, LPS increased levels of most cytokines in both phenotypes. In cortex, LPS particularly robustly increased levels of the chemokines CCL2 and CXCL10. Phenotype-specific increases were restricted to GTs, again suggesting ceiling effects in STs. These results indicate that interactions between elevated brain immune modulator signaling and CHT regulation are essential components of the neuronal underpinnings of the addiction vulnerability trait indexed by sign-tracking.
Interaction between Theta Phase and Spike Timing-Dependent Plasticity Simulates Theta-Induced Memory Effects
Authors: Wang Danying , Parish George , Shapiro Kimron L. , Hanslmayr Simon 
Published: February 2023

AbstractRodent studies suggest that spike timing relative to hippocampal theta activity determines whether potentiation or depression of synapses arise. Such changes also depend on spike timing between presynaptic and postsynaptic neurons, known as spike timing-dependent plasticity (STDP). STDP, together with theta phase-dependent learning, has inspired several computational models of learning and memory. However, evidence to elucidate how these mechanisms directly link to human episodic memory is lacking. In a computational model, we modulate long-term potentiation (LTP) and long-term depression (LTD) of STDP, by opposing phases of a simulated theta rhythm. We fit parameters to a hippocampal cell culture study in which LTP and LTD were observed to occur in opposing phases of a theta rhythm. Further, we modulated two inputs by cosine waves with 0° and asynchronous phase offsets and replicate key findings in human episodic memory. Learning advantage was found for the in-phase condition, compared with the out-of-phase conditions, and was specific to theta-modulated inputs. Importantly, simulations with and without each mechanism suggest that both STDP and theta phase-dependent plasticity are necessary to replicate the findings. Together, the results indicate a role for circuit-level mechanisms, which bridge the gap between slice preparation studies and human memory.
Involvement of GABAergic Interneuron Subtypes in 4-Aminopyridine-Induced Seizure-Like Events in Mouse Entorhinal Cortexin Vitro
Authors: Scalmani Paolo , Paterra Rosina , Mantegazza Massimo , Avoli Massimo , de Curtis Marco 
Published: February 2023

Single-unit recordings performed in temporal lobe epilepsy patients and in models of temporal lobe seizures have shown that interneurons are active at focal seizure onset. We performed simultaneous patch-clamp and field potential recordings in entorhinal cortex slices of GAD65 and GAD67 C57BL/6J male mice that express green fluorescent protein in GABAergic neurons to analyze the activity of specific interneuron (IN) subpopulations during acute seizure-like events (SLEs) induced by 4-aminopyridine (4-AP; 100 μm). IN subtypes were identified as parvalbuminergic (INPV,n= 17), cholecystokinergic (INCCK),n= 13], and somatostatinergic (INSOM,n= 15), according to neurophysiological features and single-cell digital PCR. INPVand INCCKdischarged at the start of 4-AP-induced SLEs characterized by either low-voltage fast or hyper-synchronous onset pattern. In both SLE onset types, INSOMfired earliest before SLEs, followed by INPVand INCCKdischarges. Pyramidal neurons became active with variable delays after SLE onset. Depolarizing block was observed in ∼50% of cells in each INs subgroup, and it was longer in IN (∼4 s) than in pyramidal neurons (<1 s). As SLE evolved, all IN subtypes generated action potential bursts synchronous with the field potential events leading to SLE termination. High-frequency firing throughout the SLE occurred in one-third of INPVand INSOM. We conclude that entorhinal cortex INs are very active at the onset and during the progression of SLEs induced by 4-AP. These results support earlierin vivoandin vivoevidence and suggest that INs have a preferential role in focal seizure initiation and development.SIGNIFICANCE STATEMENTFocal seizures are believed to result from enhanced excitation. Nevertheless, we and others demonstrated that cortical GABAergic networks may initiate focal seizures. Here, we analyzed for the first time the role of different IN subtypes in seizures generated by 4-aminopyridine in the mouse entorhinal cortex slices. We found that in thisin vitrofocal seizure model, all IN types contribute to seizure initiation and that INs precede firing of principal cells. This evidence is in agreement with the active role of GABAergic networks in seizure generation.
Pericyte stem cells induce Ly6G+ cell accumulation and immunotherapy resistance in pancreatic cancer
Authors: Wu Zhichong , Thierry Kevin , Bachy Sophie , Zhang Xinyi , Gamradt Pia , Hernandez‐Vargas Hector , Mikaelian Ivan , Tonon Laurie , Pommier Roxanne , Zhao Yajie , Bertolino Philippe , Hennino Ana 
Published: February 2023

AbstractWe report the identification of a cell population that shares pericyte, stromal and stemness features, does not harbor the KrasG12D mutation and drives tumoral growth in vitro and in vivo. We term these cells pericyte stem cells (PeSCs) and define them as CD45−EPCAM−CD29+CD106+CD24+CD44+ cells. We perform studies with p48‐Cre;KrasG12D (KC), pdx1‐Cre;KrasG12D;Ink4a/Arffl/fl (KIC) and pdx1‐Cre;KrasG12D;p53R172H (KPC) and tumor tissues from PDAC and chronic pancreatitis patients. We also perform single‐cell RNAseq analysis and reveal a unique signature of PeSC. Under steady‐state conditions, PeSCs are barely detectable in the pancreas but present in the neoplastic microenvironment both in humans and mice. The coinjection of PeSCs and tumor epithelial cells leads to increased tumor growth, differentiation of Ly6G+ myeloid‐derived suppressor cells, and a decreased amount of F4/80+ macrophages and CD11c+ dendritic cells. This population induces resistance to anti‐PD‐1 immunotherapy when coinjected with epithelial tumor cells. Our data reveal the existence of a cell population that instructs immunosuppressive myeloid cell responses to bypass PD‐1 targeting and thus suggest potential new approaches for overcoming resistance to immunotherapy in clinical settings.