bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of a diverse set of standard short forms based on the EORTC CAT Core item banks
Authors: Petersen Morten Aa. , Vachon Hugo , Groenvold Mogens ,   the European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Group
Published: March 2023

Abstract
Purpose
The European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Group has developed item banks covering the 14 domains of the EORTC QLQ-C30 quality of life questionnaire. These allow for dynamic assessment and for forming population/study specific static short forms. To simplify selection of relevant short forms, we here present a portfolio of standard short forms with measurement properties optimized for different populations.

Methods
For each domain, a brief and a long version were constructed for each of three populations having mild, moderate, and severe symptoms, respectively. The most informative items were prioritised while also taking content into consideration. All short forms included at least one QLQ-C30 item. The measurement precision/power of the short forms was compared to the corresponding QLQ-C30 scales using simulations.

Results
In total, 84 short forms were constructed. The brief versions included 3–5 items each, the long versions 5–9 items. Estimated sample size savings using the suggested short forms while maintaining the same power as with the QLQ-C30 ranged 3–50% across domains with median savings of 19% (brief versions) and 28% (long versions), respectively.

Conclusion
The suggested short forms allow for simple selection of items particularly relevant for patients with mild, moderate, or severe symptoms, respectively. They facilitate the use of smaller samples without loss of power compared to the QLQ-C30 scales. The suggested short forms may be used as they are or adapted to the specific aims of individual studies/settings.
The Method of Observation in Science Education: Characteristic Dimensions from an Educational Perspective
Authors: Kraus Simon F. 
Published: March 2023

AbstractObservation is widely regarded as a fundamental way of studying nature. However, due to its complexity, proposing a comprehensive characterization is challenging. Observation is a method of studying nature that can be divided into several dimensions. Each of these dimensions can be presented as a pair of terms, which are elaborated in this paper based on the epistemological, philosophical, and educational literature. In addition, the dimensions can be assigned to two levels, which can be used to group the individual dimensions. This epistemological perspective on the method is enriched by historical examples from different periods in physics and astronomy to substantiate and illustrate the classifications. The aim of the paper is to provide an overview of the epistemological features of the method in terms of these dimensions, which may be helpful for discussions in teacher training courses.
A Critique of Existential Loneliness
Authors: Gallagher Shaun 
Published: March 2023

AbstractAfter a brief review of different definitions and types of loneliness I offer an analysis of the concept of existential loneliness and its philosophical background. In contrast to the interpersonal aspects of other types of loneliness, existential loneliness has been characterized as an intrapersonal default state of incommunicability or profound aloneness, part of or based on a fundamental ontological or transcendental structure in human existence. There are both conceptual and practical issues with the notion of existential loneliness, with implications for psychotherapy. I offer a critical approach, and argue that there is no good philosophical basis for this conception of existential loneliness, and that although loneliness can be existential in some respect, it typically manifests itself in interpersonal contexts, and should not be considered a fundamental ontological structure of human existence.
Efficient adsorption of cesium cations and chromate anions by one-step process using surfactant-modified zeolite
Authors: Hamoud Moustafa A. , Abo-Zahra Shereen F. , Attia Mohamed A. , Someda Hanan H. , Mahmoud Mamdoh R. 
Published: March 2023

Abstract
Natural zeolite is organically modified with the surfactant cetyltrimethylammonium bromide (CTAB) and employed as a dual-function material for simultaneous adsorption of Cs+ cations and HCrO4− anions from aqueous solutions. Unmodified and modified zeolites are characterized by Fourier transform infrared (FTIR), dynamic light scattering (DLS), nitrogen adsorption–desorption isotherms, and X-ray diffraction (XRD). The results showed that CTAB-zeolite had the efficiency to simultaneously adsorb the concerned species in the pH range 2.5–4.2. The kinetic data showed that 90 and 300 min for Cs(I) and Cr(VI), respectively, were sufficient to attain equilibrium and the data are well-fitted by the double-exponential kinetic model. Of the studied adsorption isotherm models, Redlich-Peterson was the best one for describing the equilibrium adsorption isotherms. Values of ∆H°, ∆S°, and ∆G° for the present adsorption processes are estimated. CTAB-zeolite exhibited adsorption capacities of 0.713 and 1.216 mmol/g for Cs(I) and Cr(VI), respectively, which are comparable with the data reported in the literature. The adsorption mechanism of the concerned (radio)toxicants is proposed.
Microstructural Evolution of Ni-SiC Composites Manufactured by Spark Plasma Sintering
Authors: Chmielewski Marcin , Zybała Rafał , Strojny-Nędza Agata , Piątkowska Anna , Dobrowolski Artur , Jagiełło Jakub , Diduszko Ryszard , Bazarnik Piotr , Nosewicz Szymon 
Published: March 2023

Abstract
The presented paper concerns the technological aspects of the interface evolution in the nickel-silicon carbide composite during the sintering process. The goal of our investigation was to analyse the material changes occurring due to the violent reaction between nickel and silicon carbide at elevated temperatures. The nickel matrix composite with 20 vol pct SiC particles as the reinforcing phase was fabricated by the spark plasma sintering technique. The sintering tests were conducted with variable process conditions (temperature, time, and pressure). It was revealed that the strong interaction between the individual components and the scale of the observed changes depends on the sintering parameters. To identify the microstructural evolution, scanning electron microscopy, energy dispersive spectroscopy, transmission electron microscopy, X-ray diffraction, and Raman spectroscopy were used. The silicon carbide decomposition process progresses with the extension of the sintering time. As the final product of the observed reaction, new phases from the Ni-Si system and free carbon were detected. The step-by-step materials evolution allowed us to reveal the course of the reaction and the creation of the new structure, especially in the reaction zone. The detailed analysis of the SiC decomposition and formation of new components was the main achievement of the presented paper.
Genetic Testing in Familial Hypercholesterolemia: Is It for Everyone?
Authors: Medeiros A. M. , Bourbon M. 
Published: March 2023

Abstract
Purpose of Review
Lipid measurements and genetic testing are the main diagnostic tools for FH screening that are available in many countries. A lipid profile is widely accessible, and genetic testing, although available worldwide, in some countries is only performed in a research context. Still FH is diagnosed late, showing lack of early screening programs worldwide.

Recent Findings
Pediatric screening of FH was recently recognized by the European Commission Public Health Best Practice Portal as one on the best practices in non-communicable disease prevention. The early diagnosis of FH and the lowering of LDL-C values over lifespan can reduce the risk of coronary artery disease and offer health and socioeconomic gains.

Summary
Current knowledge about FH shows that early detection through appropriate screening needs to become a priority in healthcare systems worldwide. Governmental programs for FH identification should be implemented to unify the diagnosis and increase patient identification.
A multimodal sentiment analysis system for recognizing person aggressiveness in pain based on textual and visual information
Authors: Ghosh Anay , Dhara Bibhas Chandra , Pero Chiara , Umer Saiyed 
Published: March 2023

AbstractThis article proposes a multimodal sentiment analysis system for recognizing a person’s aggressiveness in pain. The implementation has been divided into five components. The first three steps are related to a text-based sentiment analysis system to perform classification tasks such as predicting the classes into non-aggressive, covertly aggressive, and overtly aggressive classes. The remaining two components are related to an image-based sentiment analysis system. A deep learning-based approach has been employed to do feature learning and predict the three types of pain classes. An aggression dataset for the text-based system and the UNBC-McMaster database for an image-based system has been employed, respectively. Experimental results have been compared with the state-of-the-art methods, showing the superiority of the proposed approach. Finally, the scores due to text-based and image-based sentiment analysis systems are fused to obtain the performance for the proposed multimodal sentiment analysis system.
Effects of a preseason triphasic resistance training program on athletic performance in elite volleyball players—an observational study
Authors: Rebelo André , Pereira João R. , Valente-dos-Santos João 
Published: March 2023

AbstractVolleyball is a sport that requires high levels of maximal strength, reactive strength, and power at the elite level. Various training methods exist to maximize these physical qualities. The purpose of the triphasic training method is to maximize sport performance by enhancing all three muscle actions to create a strong link between eccentric, isometric, and concentric phases. The purpose of this study is to assess the impact of a 6-week (three times per week) triphasic resistance training program during the preseason period in professional male volleyball athletes. Fourteen male elite volleyball players (mean [± standard deviation] age: 28.88 ± 5.59 years; height: 192 ± 10 cm; body mass: 88.00 ± 14.54 kg) completed several body composition assessments and physical tests. Squat jump performance (p = 0.02, d = 0.27, 3.16%) and both lower (p < 0.001, d = 0.71, 16.56%) and upper body (p = 0.002, d = 0.45, 7.98%) maximal strength significantly increased from pre to post intervention. Strength and conditioning professionals should consider this type of training if they seek to improve maximal strength and concentric power. However, if the goals are to improve reactive strength and change-of-direction speed, then coaches must shift towards a power-type training to improve these stretch-shortening cycle activities.
Estrogen-dependent activation of NCOA3 couples with p300 and NF-κB to mediate antiapoptotic genes in ER-positive breast cancer cells
Authors: Wang Jun , Zhou Zhiyong 
Published: March 2023

AbstractCircumvention of apoptosis by the elevation of antiapoptotic proteins is an important cause of carcinogenesis. The induction of antiapoptotic genes, including B-cell CLL/lymphoma 2 (BCL2), BCL2 related protein A1 (BCL2A1), BCL2 like 1 (BCL2L1), BCL2L2, and myeloid cell leukemia 1 (MCL1), has been observed in multiple cancers, including breast cancer. However, the underlying mechanisms of their overexpression are still being investigated. Here, we revealed that BCL2, BCL2A1, BCL2L2, and MCL1 but not BCL2L1 were overexpressed in estrogen receptor (ER)-positive breast cancer cells and clinical biopsies. Stimulation with estrogen in ER-positive cell lines resulted in a dose-dependent increase in BCL2, BCL2A1, BCL2L2, and MCL1 mRNA levels. Molecular investigation revealed that nuclear factor kappa B (NF-κB) recruited histone acetyltransferase p300 and nuclear receptor coactivator 3 (NCOA3) to form a transcriptional complex. This complex docked the promoters of BCL2, BCL2A1, BCL2L2, and MCL1 and activated their expression. Interestingly, estrogen exposure dose-dependently activated NCOA3. Depletion of the NCOA3-p300-NF-κB components or blockage of NCOA3 function with inhibitors (gossypol and bufalin) in ER-positive cells suppressed BCL2, BCL2A1, BCL2L2, and MCL1 expression, while also decreasing cell viability, colony formation, cell invasion, and tumor growth. Collectively, our results demonstrate an upstream signaling that activates four antiapoptotic genes in ER-positive breast cancer cells. Importantly, our results also imply that targeting NCOA3 or blocking the assembly of the NCOA3-p300-NF-κB complex may be promising therapeutic strategies for treating ER-positive breast cancer.
Hydrogeochemical studies of groundwater in semi-arid areas of northern Ethiopia using geospatial methods and multivariate statistical analysis techniques
Authors: Hailu Haftay , Haftu Solomon 
Published: March 2023

AbstractThe present study focused on evaluating the groundwater hydrogeochemical of shallow aquifers in the semi-arid areas of northern Ethiopia, using geospatial modelling and multivariate statistical techniques. Physico-chemical parameters, including pH, major ions, electrical conductivity (EC), total dissolved solids (TDS), total hardness (TH), pollution index (PI) and other parameters, from 22 samples have been used to assess water quality, sources of various ions, water types and factors controlling groundwater chemistry. Results showed that the spatial distribution of major ions, EC, TDS, TH and PI values in these samples significantly differ from one location to another due to geological variations and anthropogenic activities of the area. The quality of most groundwater is generally unfit for drinking due to their PI, EC, TH, calcium, potassium, total iron and bicarbonate (HCO3−) values that found to be above the permissible limits of WHO and Ethiopian standards. The parameters like sodium percentage, sodium adsorption ratio (SAR), residual sodium bicarbonate, permeability index, magnesium hazard and Kelly’s ratio revealed good quality of groundwater for irrigation utilization, whereas EC of irrigation water (ECiw), combined effects of ECiw − SAR and bicarbonate hazard values indicated that majority of groundwater are not suitable for irrigation use. Piper trilinear diagram classified majority of samples under temporary hardness with Ca–Mg–HCO3 type. Further, Gibbs diagram reveals that water–rock interaction is the major hydrogeochemical processes governing the water chemistry of the study area. Therefore, it is recommended to perform a constant water quality checking program and improvement of tangible management practices for sustainable utilization of groundwater resources.
Structural Design for Roll-Formed Aluminium Alloy Perforated Channels Subjected to Interior-Two-Flange Web Crippling: Experimental Tests, Numerical Simulation, and Neural Network
Authors: Fang Zhiyuan , Roy Krishanu , Lim James B. P. 
Published: March 2023

AbstractThis study analyses the interior-two-flange (ITF) web crippling strength of roll-formed aluminum alloy lipped channels (RA channels) with web holes employing experimental testing, numerical modeling, and deep neural network (i.e., Deep belief Network, DBN). A total of 30 experimental tests on web crippling behavior were carried out, with the results utilized to validate a finite element (FE) model, developed in this study. The experimental results were compared to the data produced by the validated FE model, which was then used to train the DBN model. The results of the DBN prediction were shown to be around 5% more conservative than the FE results. In order to evaluate the effects of associated factors on the ITF web crippling strength of RA channels, a comprehensive parametric study was conducted using the DBN. The design guidelines that are currently available in the American Iron and Steel Institute (AISI 2016), the Australian and New Zealand Standards (AS/NZS 1997; AS/NZS (2018)), and the Eurocode (CEN 2007) were found to be unreliable while determining the ITF web crippling strength of RA channels. The DBN's predictions developed new formulae for calculating the web crippling strength reduction factors. After conducting a reliability study, it was found that the developed strength reduction factor equations are reliable when calculating the ITF web crippling strength of such perforated roll-formed aluminium alloy channels.
Laparoscopic antireflux surgery for refractory gastroesophageal reflux disease: long-term clinical outcomes
Authors: Ugliono Elettra , Rebecchi Fabrizio , Mantova Serena , Osella Giulia , Mansour Ahmed Mohammed Farid Mahmoud Hamdy , Morino Mario 
Published: March 2023

AbstractPersistent symptoms despite adequate Proton Pump Inhibitors (PPI) treatment are described in up to 40% of patients with Gastroesophageal Reflux Disease (GERD). The efficacy of Laparoscopic Antireflux Surgery (LARS) in PPI non-responder patients is still unclear. This observational study aims to report the long-term clinical outcomes and predictors of dissatisfaction in a cohort of refractory GERD patients submitted to LARS. Patients with preoperative refractory symptoms and objective GERD evidence submitted to LARS between 2008 and 2016 were included in the study. Primary endpoint was overall satisfaction with the procedure, secondary endpoints were long-term GERD symptom relief and endoscopic findings. Univariate and multivariate analyses were performed to compare satisfied and dissatisfied patients, in order to identify preoperative predictors of dissatisfaction. A total of 73 refractory GERD patients who underwent LARS were included in the study. At a mean follow-up of 91.2 ± 30.5 months, the satisfaction rate was 86.3%, with a statistically significant reduction in typical and atypical GERD symptoms. Causes of dissatisfaction were severe heartburn (6.8%), gas bloat syndrome (2.8%), and persistent dysphagia (4.1%). Multivariate analysis showed that a number of Total Distal Reflux Episodes (TDRE) > 75 was a predictive factor of long-term dissatisfaction after LARS while a partial response to PPI was a protective factor against dissatisfaction. LARS guarantees a high level of long-term satisfaction for selected refractory GERD patients. An abnormal TDRE at 24 h-multichannel intraluminal impedance-pH monitoring and the lack of response to preoperative PPI were predictors of long-term dissatisfaction.
Emotions and Automation in a High-Tech Workplace: a Commentary
Authors: Umbrello Steven 
Published: March 2023

Abstract
In a recent article, Madelaine Ley evaluates the future of work, specifically robotised workplaces, via the lens of care ethics. Like many proponents of care ethics, Ley draws on the approach and its emphasis on relationality to understand ethical action necessary for worker wellbeing. Her paper aims to fill a research gap by shifting away from the traditional contexts in which care ethics is employed, i.e., health and care contexts and instead appropriates the approach to tackle the sociotechnicity of robotics and how caring should be integrated into non-traditional contexts. This paper comments on that of Ley’s, making the case that the author does, in fact, achieve this end while still leaving areas of potential future research open to buttressing the approach she presents.
Considerations for Contraceptive Use Among Patients with Migraines
Authors: Lyall Melinda , de Oliveira Bella Ribeiro , Mody Sheila K. 
Published: March 2023

Abstract
Purpose of Review
There is an overlap in the populations of patients who suffer from migraine headaches and patients who seek contraception. The purpose of this review is to present recent studies on contraception among patients with migraines and provide clinical recommendations.

Recent Findings
Migraine with aura and combined hormonal contraceptive (CHC) use are associated with increased ischemic stroke risk. The use of CHCs in patients with migraine with aura produces a higher risk of ischemic stroke than either factor individually; therefore, CHC is contraindicated in this population by certain guidelines. However, recent studies suggest that oral contraceptive may reduce migraine days, pain scores, and migraine medication use.

Summary
Certain guidelines recommend against use of CHCs in patients with migraine with aura. CHC use is acceptable among patient with migraines without aura. In patients with menstrual-related migraines, there may be benefit from continuous use of oral contraceptives. Further studies are needed on migraine and specific formulations of CHC, if the frequency of migraines with aura impacts ischemic stroke risk and the impact of oral and non-oral contraceptives on menstrual headaches.
Wear mechanism and debris analysis of PEEK as an alternative to CoCrMo in the femoral component of total knee replacement
Authors: Zhang Xinyue , Zhang Tao , Chen Kai , Xu Handong , Feng Cunao , Zhang Dekun 
Published: March 2023

AbstractThe polyetheretherketone (PEEK)-highly cross-linked polyethylene (XLPE), all-polymer knee prosthesis has excellent prospects for replacing the traditional metal/ceramic-polyethylene joint prosthesis, improving the service life of the joint prosthesis and the quality of patients’ life. The long-term wear mechanism of PEEK-XLPE knee joint prosthesis is comprehensively evaluated from wear amount, wear morphology, and wear debris compared to that of CoCrMo-XLPE joint prosthesis. After 5 million cycles ofin vitrowear, the wear loss of XLPE in PEEK-XLPE (30.9±3.2 mg) is lower than that of XLPE in CoCrMo-XLPE (32.1±3.1 mg). Compared to the XLPE in CoCrMo-XLPE, the plastic deformation of XLPE in PEEK-XLPE is more severe in the early stage, and the adhesive peeling and adhesion are lighter in the later stage. The size distribution of XLPE wear debris in PEEK-XLPE is relatively dispersed, which in CoCrMo-XLPE is relatively concentrated. Wear debris is mainly flake and block debris, and the wear mechanism of XLPE was abrasive wear. The wear volume per unit area of PEEK femoral condyle (10.45×105µm3/mm2) is higher than that of CoCrMo (8.32×105µm3/mm2). The PEEK surface is mainly furrows and adhesions, while the CoCrMo surface is mainly furrows and corrosion spots. The PEEK wear debris is mainly in flakes and blocks, and the CoCrMo wear debris is mainly in the shape of rods and blocks. The wear mechanism of PEEK is abrasive wear and adhesion, and that of CoCrMo is abrasive wear and corrosion.