bluuebunny/crossref_metadata_2025_split huggingface dataset:
Freedom, moral responsibility, and the failure of universal defeat
Authors: Latham Andrew J. , Tierney Hannah , Varga Somogy 
Published: August 2023

AbstractProponents of manipulation arguments against compatibilism hold that manipulation scope (how many agents are manipulated) and manipulation type (whether the manipulator intends that an agent perform a particular action) donotimpact judgments about free will and moral responsibility. Many opponents of manipulation arguments agree that manipulation scope has no impact but hold that manipulation type does. Recent work by Latham and Tierney (2022, 2023) found that people's judgments were sensitive to manipulation scope: people judged that an agent waslessfree and responsible when a manipulation was existential (impacting at least one but not all agents) than when the manipulation was universal (impacting every agent). This study examines people's judgements about existential and universal manipulation cases that involve both intentional and non‐intentional outcomes. We found that manipulation scope also affects people's free will and responsibility judgments in manipulation cases involving both intentional and non‐intentional outcomes. Interestingly, we also found that manipulation type influences the effect that manipulation scope has on people's free will judgments but not their moral responsibility judgments, which indicates that people's free will and responsibility judgments can come apart. This puts pressure on the prevalent assumption that judgments about free will and moral responsibility are conceptually bound together.
Ameliorative effect of chitosan nanoparticles in capacitation media on post‐thawing in vitro fertilizing ability of bovine spermatozoa
Authors: Mahmoud Mona , Abd‐Allah Saber M. , Abdel‐Halim Bakar R. , Khalil Abdeltawab A.Y. 
Published: August 2023

AbstractThis study aimed to investigate the effect of supplementation of chitosan nanoparticles (CSNPs) on the capacitation of bovine spermatozoa during the in vitro fertilization process. Hyperactivated motility (HAM) and acrosome reaction (AR) of sperm cells as well as in vitro fertilization and cleavage rates are the main parameters used to estimate the effect of CSNPs on bovine spermatozoa's fertilizing ability. In this study, three different concentrations of CSNPs (10, 20 and 100 μg/mL) were prepared and characterized. Motile spermatozoa were separated from frozen–thawed semen by a swim‐up technique and capacitated in Sperm‐TALP medium supplemented with heparin only without CSNPs treatment (positive control), heparin + 10 μg/mL CSNPs, heparin + 20 μg/mL CSNPs, heparin + 100 μg/mL CSNPs and the last one served as a negative control tube which supplemented with 10 μg/mL CSNPs without adding heparin. Sperm cells were incubated for 90 min at 39°C in a 5% CO2 incubator and evaluated every 30 min at intervals. Cumulus oophorus complex (COCs) were matured in a 5% CO2 incubator at 39°C and inseminated in vitro with frozen–thawed bull sperm of the above concentrations. The inseminated oocytes were incubated at 39°C in a 5% CO2 incubator for 24 h and then examined for evidence of fertilization. The results of this investigation showed that HAM and AR were best affected by CSNPs at a concentration of 20 μg/mL during an incubation time of 60 min. As time went on, the overall proportion of spermatozoa with progressive motility (PM) decreased across all groups, and a substantially lower value was found at the dose mentioned above. Additionally, the impact of sperm treated with CSNPs on fertilization rate was assessed. The outcomes demonstrated that in comparison to the other concentrations (10 and 100 μg/mL), the positive control and the negative control, the proportion of fertilized oocytes was significantly higher in the CSNPs concentration (20 μg/mL). In conclusion, it could be inferred from this investigation that CSNPs support sperm functions during IVF and can be used for biomedical interventions in bovine spermatozoa. Additionally, a high IVF rate was achieved by using sperm treated with CSNPs as CSNPs enhance sperm capacitation and acrosome reaction.
Rogue waves arising on the standing periodic waves in the Ablowitz–Ladik equation
Authors: Chen Jinbing , Pelinovsky Dmitry E. 
Published: August 2023

AbstractWe study the standing periodic waves in the semidiscrete integrable system modeled by the Ablowitz–Ladik (AL) equation. We have related the stability spectrum to the Lax spectrum by separating the variables and by finding the characteristic polynomial for the standing periodic waves. We have also obtained rogue waves on the background of the modulationally unstable standing periodic waves by using the end points of spectral bands and the corresponding eigenfunctions. The magnification factors for the rogue waves have been computed analytically and compared with their continuous counterparts. The main novelty of this work is that we explore a nonstandard linear Lax system, which is different from the standard Lax representation of the AL equation.
Test–retest reliability of ski‐specific aerobic, sprint, and neuromuscular performance tests in highly trained cross‐country skiers
Authors: Bucher Elias , Millet Grégoire P. , Wehrlin Jon P. , Steiner Thomas 
Published: August 2023

AbstractPurposeLaboratory tests are commonly performed by cross‐country (XC) skiers due to the challenges of obtaining reliable performance indicators on snow. However, only a few studies have reported reliability data for ski‐specific test protocols. Therefore, this study examined the test–retest reliability of ski‐specific aerobic, sprint, and neuromuscular performance tests.MethodsThirty‐nine highly trained XC skiers (26 men and 13 women, age: 22 ± 4 years, V̇O2max: 70.1 ± 4.5 and 58.8 ± 4.4 mL·kg−1·min−1, respectively) performed two test trials within 6 days of a diagonal V̇O2max test, n = 27; skating graded exercise test to assess the second lactate threshold (LT2), n = 27; 24‐min double poling time trial (24‐min DP, n = 25), double poling sprint test (SprintDP1, n = 27), and 1‐min self‐paced skating sprint test (Sprint1‐min, n = 26) using roller skis on a treadmill, and an upper‐body strength test (UB‐ST, n = 27) to assess peak power (Ppeak) with light, medium, and heavy loads. For each test, the coefficient of variation (CV), intraclass correlation coefficient (ICC), and minimal detectable change (MDC) were calculated.ResultsV̇O2max demonstrated good‐to‐excellent reliability (CV = 1.4%; ICC = 0.99; MDC = 112 mL·min−1), whereas moderate‐to‐excellent reliability was found for LT2 (CV = 3.1%; ICC = 0.95). Performance during 24‐min DP, SprintDP1, and Sprint1‐min showed good‐to‐excellent reliability (CV = 1.0%–2.3%; ICC = 0.96–0.99). Absolute reliability for UB‐ST Ppeak was poor (CV = 4.9%–7.8%), while relative reliability was excellent (ICC = 0.93–0.97) across the loads.ConclusionIn highly trained XC skiers, sport‐specific aerobic and sprint performance tests demonstrated high test–retest reliability, while neuromuscular performance for the upper body was less reliable. Using the presented protocols, practitioners can assess within‐ and between‐season changes in relevant performance indicators.
Heterogeneous trade agreements and adverse implications of restrictive rules of origin: Evidence from apparel trade
Authors: Abreha Kaleb , Robertson Raymond 
Published: August 2023

AbstractWe revisit the heterogeneous effects of regional trade agreements (RTAs) using a PPML gravity model and comparing apparel and total trade. Apparel, as a politically sensitive sector, has specialised, unusually restrictive rules of origin (RoOs) clauses that vary considerably across RTAs. Our RTA estimates have a significantly higher variance for apparel trade than total trade. We also find that the sizes of the RTA estimates for apparel trade are significantly and negatively correlated with the restrictiveness of RoOs. Additionally, assessing temporary exceptions to the apparel RoOs in US trade agreements, we find that ending the temporary exceptions is associated with less apparel trade. We further illustrate how RTAs can be effective development policy instruments to promote economic development in developing countries. For example, updating the RoOs in the Dominican Republic‐Central America Free Trade Agreement can create jobs and significantly reduce Central American emigration.
Descriptive analysis of haemangiosarcoma occurrence in dogs enrolled in the Golden Retriever lifetime study
Authors: Hillman Alison , Swafford Brenna , Delavenne Camille , Fieten Hille , Boerkamp Kim , Tietje Kathy 
Published: August 2023

AbstractHaemangiosarcoma is a relatively common malignant tumour in dogs, and one of the primary outcomes of interest for the Golden Retriever Lifetime Study. This study collects longitudinal data and samples from a cohort of golden retrievers, with the aim of identification of nutritional, genetic, environmental, lifestyle and reproductive risk factors for cancers and other important diseases in dogs. This analysis describes the accumulating data and samples, which are available for use by researchers to fulfil the study's objectives. As of September 2022, 233/3044 dogs enrolled in the study had been diagnosed with haemangiosarcoma (7.65%), with an incidence rate of 1.10 cases per 100 dog‐years. Visceral haemangiosarcoma was the most common, affecting 211/3044 study dogs (6.9%). One hundred and twenty eight visceral haemangiosarcoma diagnoses specified the presence of splenic tumours (60.7%) and 119 specified the presence of cardiac tumours (56.4%). The probability of remaining without a haemangiosarcoma diagnosis declined from 100% from approximately 4 years of age, to a 12 year probability of 91.1% in intact females (95% CI 84.4%–98.3%), 60.7% in neutered females (95% CI 41.6%–88.6%), 72.9% in intact males (95% CI 62.9%–84.6%) and 70.0% in neutered males (95% CI 53.4%–92.0%). The 1 year survival probability for visceral haemangiosarcoma was 1.42% (95% CI 0.37%–5.47%); for cutaneous haemangiosarcoma, it was 84.6% (95% CI 67.1%–99.99%). The accumulated data and samples are a considerable resource for further investigation of canine haemangiosarcoma and have a potential role in translational medicine.
The fallacy of functional nomenclature in the kingdom of biological multifunctionality: physiological and evolutionary considerations on ion channels
Authors: Munaron Luca , Chinigò Giorgia , Scarpellino Giorgia , Ruffinatti Federico Alessandro 
Published: August 2023

AbstractLiving organisms are multiscale complex systems that have evolved high degrees of multifunctionality and redundancy in the structure–function relationship. A number of factors, only in part determined genetically, affect the jobs of proteins. The overall structural organization confers unique molecular properties that provide the potential to perform a pattern of activities, some of which are co‐opted by specific environments. The variety of multifunctional proteins is expanding, but most cases are handled individually and according to the still dominant ‘one structure–one function’ approach, which relies on the attribution of canonical names typically referring to the first task identified for a given protein. The present topical review focuses on the multifunctionality of ion channels as a paradigmatic example. Mounting evidence reports the ability of many ion channels (including members of voltage‐dependent, ligand‐gated and transient receptor potential families) to exert biological effects independently of their ion conductivity. ‘Functionally based’ nomenclature (the practice of naming a protein or family of proteins based on a single purpose) is a conceptual bias for three main reasons: (i) it increases the amount of ambiguity, deceiving our understanding of the multiple contributions of biomolecules that is the heart of the complexity; (ii) it is in stark contrast to protein evolution dynamics, largely based on multidomain arrangement; and (iii) it overlooks the crucial role played by the microenvironment in adjusting the actions of cell structures and in tuning protein isoform diversity to accomplish adaptational requirements. Biological information in protein physiology is distributed among different entwined layers working as the primary ‘locus’ of natural selection and of evolutionary constraints.
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Compression Characteristics of Liquid Ring Compressors With Fixed and Freely Rotating Casings
Authors: Acarer Sercan , Gürbüz M. Tayyip , Cukurel Beni 
Published: August 2023

Abstract
Liquid ring compressors (LRC) are used for a wide range of compression and vacuum applications, including corrosive or flammable gases for which other compression technologies may not be feasible. The presence of a surrounding liquid ring may offer the possibility of polytropic compression due to incremental heat loss to the liquid. This aspect may play a critical role in compression (and expansion) processes of heat engine cycles toward approaching the targeted Carnot efficiencies. To date, published research addressing the physical phenomena behind LRC is highly limited. Experimentally studying these machines will result in a demonstration of aggregate performance. In order to improve our understanding of LRC with and without freely rotating casings and to be able to analyze the complex inner workings, a numerical approach using computational fluid dynamics (CFD) tools, supported by available experimental data for validation purposes, has been established. Physical parameters such as water–air interface, temperature, pressure, entropy production, vorticity, and shear strain rate are presented for a baseline geometry taken from the open literature. Finally, temperature-entropy paths and isothermal and isentropic efficiencies are presented. The significant performance gain from the freely rotating casing is highlighted. Detailed results present insights into work addition processes of such machines.
Thermoelastohydrodynamic Mixed Lubrication of Combined Rod Seals Operating at High Pressures and Speeds: Mathematical Modeling and Numerical Analysis
Authors: Wang Bingqing , Li Xiaoxuan , Peng Xudong , Li Yuntang , Chen Yuan , Jin Jie 
Published: August 2023

Abstract
Thermoelastohydrodynamic (TEHD) mixed lubrication characteristics of a step-combined rod seal under high-pressure and high-speed conditions are analyzed in this article. A novel TEHD mixed lubrication model for combined rod seals is innovatively established from the perspective of “seal-film-rod” system for the first time. Parameterized studies are conducted to evaluate the thermal effect on seal behavior with the comparison of isothermal elastohydrodynamic (EHD) lubrication analysis. Numerical results show that the interface friction heat is quite remarkable and mainly concentrated on the sealing lip, especially in high pressure and speed cases. With the increasing sealed pressure or rod speed, the temperature rise becomes more obvious and has a more significant impact on the sealing performance. The excessively rising temperature will even exceed the melting point of the sealing material, causing thermal damage.
High-quality genomes of
Paenibacillus
spp. RC334 and RC343, isolated from a long-term forest soil warming experiment
Authors: Kitzmiller Claire E. , Tran Wyatt C. , Sullivan Brendan , Cortez Florencia , Choudoir Mallory , Simoes Rachel , Dayarathne Nipuni , DeAngelis Kristen M. 
Published: August 2023

ABSTRACT

Paenibacillus
spp. RC334 and RC343 were isolated from heated soil in a long-term soil warming experiment. Both genomes were 5.98 Mb and assembled as a single contig. We describe the assembly and annotation of the two high-quality draft genomes for these isolates here.
Mycobacteriophage Rita: a cluster F1 phage discovered in North Easton, Massachusetts
Authors: Fakhri Anna M. , Warner Marcie H. , DeGiorgis Joseph A. , Cornely Kathleen 
Published: August 2023

ABSTRACT

Mycobacteriophage Rita infects
Mycobacterium smegmatis
mc
2
155 and was isolated from a soil sample collected in North Easton, Massachusetts. Assigned to cluster F1 based on sequence similarity to other phages in the same cluster, Rita has a 58,771 bp genome and encodes 104 genes. Rita is 98% similar to phage Bipolar.
Supramolecular Strategy for the Design of Nanocarriers for Drugs and Natural Bioactives: Current State of the Art (A Review)
Authors: Zakharova L. Ya. , Maganova F. I. , Sinyashin K. O. , Gaynanova G. A. , Mirgorodskaya A. B. , Vasilieva E. A. , Sinyashin O. G. 
Published: August 2023

AbstractThe review focuses on the lipid based nanocarriers, with special attention paid to natural bioactive payloads. First, micelles and microemulsions are considered as very attractive colloidal nanocontainers that allow for marked improving the solubility of hydrophobic bioactives. Further, liposomal vehicles are reviewed, with both advantages and limitations discussed. Literature assay covers up-to-date information of about last three to five years, although brief background is given on the pioneer works addressing the liposomes and their evolution from bench to bedside. Final part of the review is devoted to the modern modifications of vesicular nanocarriers which can be adapted to specific administration way due to improved targeting properties, permeability, mucoadhesiveness and possibility to cross biological barriers. Therein, such kinds of nanocarriers as transfersomes, niosomes, ethosomes, chitosomes are evaluated; and separate sections focus on the natural based formulations, i.e., phytosomes and invasomes.
Predictors of harsh parenting practices and inter-partner conflict during the COVID-19 pandemic in Ontario, Canada: a cross-sectional analysis from the Ontario Parent Survey
Authors: Joshi Divya , Aschner Amir , Atkinson Leslie , Halili-Sychangco Daniella , Duku Eric , Puffer Eve S , Rieder Amber , Tonmyr Lil , Gonzalez Andrea 
Published: August 2023

ObjectivesGuided by the bioecological model, the purpose of this study was to examine the associations of (1) individual level factors (sociodemographic, health behaviour and mental health), (2) family (micro) level COVID-19 experiences (difficulty with household management, managing child mood and behaviour, and pandemic-related positive experiences) and (3) community (macro) level factors (residential instability, ethnic concentration, material deprivation and dependency, an indicator of age and labour force) with harsh parenting practices and inter-partner conflict during the early lockdown of the COVID-19 pandemic in Ontario, Canada.DesignA cross-sectional analysis of data from the Ontario Parent Survey.SettingA convenience sample of 7451 caregivers living in Ontario, Canada, at the time of baseline data collection (May–June 2020).ParticipantsCaregivers aged 18 years and older with children 17 years or younger.Outcome measuresParenting practices over the past 2 months was assessed using a published modification of the Parenting Scale. The frequency of inter-partner conflict over the past month was assessed using the Marital Conflict scale.ResultsIndividual (sociodemographic factors, alcohol use, and higher depressive and anxiety symptoms) and family (difficulties with managing the household and child mood and behaviour) level factors were positively associated with inter-partner conflict and harsh parenting practices. Having fewer positive experiences (eg, performing activities with children), and economic adversity at the family level were positively associated with inter-partner conflict but inversely associated with harsh parenting. At the community level, residential instability was negatively associated with harsh parenting practices.ConclusionsIndividual and family level factors were associated with harsh parenting and inter-partner conflict. The associations of fewer positive experiences and economic hardship with harsh parenting practices may be more complex than initially thought. Efforts that raise awareness and address caregiver mental health concerns are needed as part of the pandemic response to promote positive inter-partner and parent-child interactions.
Efficacy of a medical grade honey formulation (L-Mesitran) in comparison with fluconazole in the treatment of women with recurrent vulvovaginal candidiasis: protocol for a randomised controlled trial (HONEY STUDY)
Authors: van Riel Senna J J M , Lardenoije Céline M J G , Wassen Martine M L H , van Kuijk Sander M J , Cremers Niels A J 
Published: August 2023

IntroductionRecurrent vulvovaginal candidiasis (RVVC) affects up to 9% of women worldwide. This amount is expected to increase due to lifestyle changes, increased fungal resistance and biofilm formation. Treatment options are limited and in 57% of the cases, relapses occur within 12 months after starting fluconazole therapy (golden standard). The pathogenesis of RVVC is multifactorial and includes fungal biology, the vaginal microenvironment and the immune system. Fluconazole is antimicrobial and effective in inducing short-term remission but a long-term cure is hard to achieve. Medical grade honey (MGH) has antimicrobial, protective, antioxidative and immunomodulatory activity and may therefore be a good alternative treatment. This study aims to investigate the clinical cure rate and long-term efficacy of MGH compared with fluconazole in patients with RVVC.Methods and analysisThis study is a multicentre, randomised controlled trial (Maastricht University Medical Centre+ and Zuyderland Medical Centre). A total of 252 eligible women will be randomly assigned to the fluconazole group (control) or the MGH group (L-Mesitran, treatment). The primary objective is to investigate the mycological cure rate after 1 month assessed through a vaginal culture. Secondary objectives are the clinical cure rate regarding symptoms, the prophylactic activity after 6 months of maintenance therapy and the number of relapses within 12 months. Moreover, information about side effects, discomfort and quality of life will be collected with the use of questionnaires.Ethics and disseminationEthical approval from the Medical Ethics Review Committee of the academic hospital Maastricht/University Maastricht has been obtained (NL 73974.068.21, V.7 on 8 February 2022). Additional approval was obtained from the Ethics Committee of the Zuyderland Medical Centre Heerlen (Z2021141 on 4 March 2022). The first patient was randomised on 22 August 2022. Results will be made available to researchers and healthcare professionals via conferences, meetings and peer-reviewed international publications.Trial registration numberNCT05367089.