bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identifying behavioural barriers and facilitators to engaging men in a community-based lifestyle intervention to improve physical and mental health and well-being
Authors: Bell Oliver J. , Flynn Darren , Clifford Tom , West Daniel , Stevenson Emma , Avery Leah 
Published: March 2023

AbstractBackgroundThere are few community-based lifestyle interventions designed to target physical and mental health of men. We conducted a qualitative focus group study with men to explore their perceived barriers and facilitators to uptake and engagement with interventions designed to improve their physical and mental health and wellbeing.MethodsA volunteer sampling approach (advertisements posted on a premier league football club’s social media) was used to recruit men aged 28 to 65 years who were interested in improving their physical and/or mental health and wellbeing. Focus group discussions were conducted at a local premier league football club to 1) explore men’s perceived barriers and facilitators to uptake of community-based interventions; 2) identify health issues considered important to address; 3) obtain participant views on how to best engage men in community-based interventions; and 4) use the findings to inform the development of a multibehavioural complex community-based intervention (called ‘The 12thMan’).ResultsSix focus group discussions were conducted (duration 27 to 57 min) involving 25 participants (median age 41 years, IQR = 21 years). Thematic analyses generated seven themes: ‘Lifestyle behaviours for both mental health and physical health’; ‘work pressures are barriers to engaging with lifestyle behaviour change’; previous injuries are barriers to engagement in physical activity and exercise’; personal and peer group relationships impact on lifestyle behaviour change’; relationships between body image and self-confidence on mastery of skills for physical activity and exercise’; building motivation and personalised goal setting’; and ‘credible individuals increase uptake and continued engagement with lifestyle behaviour change’.ConclusionsFindings suggest that a multibehavioural community-based lifestyle intervention designed for men should promote parity of esteem between physical and mental health. It should also acknowledge individual needs and preferences, emotions in the context of goal setting and planning, and be delivered by a knowledgeable and credible professional. The findings will inform the development of a multibehavioural complex community-based intervention (‘The 12thMan’).
Interaction of the Zika virus with the cytoplasmic dynein-1
Authors: Zavala-Vargas Dan Israel , Visoso-Carbajal Giovani , Cedillo-Barrón Leticia , Filisola-Villaseñor Jessica Georgina , Rosales-Ramirez Romel , Ludert Juan E. , Morales-Ríos Edgar 
Published: March 2023

AbstractZika virus (ZIKV) infection is a major public health threat, making the study of its biology a matter of great importance. By analyzing the viral–host protein interactions, new drug targets may be proposed. In this work, we showed that human cytoplasmic dynein-1 (Dyn) interacts with the envelope protein (E) of ZIKV. Biochemical evidence indicates that the E protein and the dimerization domain of the heavy chain of Dyn binds directly without dynactin or any cargo adaptor. Analysis of this interactions in infected Vero cells by proximity ligation assay suggest that the E–Dyn interaction is dynamic and finely tuned along the replication cycle. Altogether, our results suggest new steps in the replication cycle of the ZIKV for virion transport and indicate a suitable molecular target to modulate infection by ZIKV.
Evaluation of quality of life in lung cancer patients receiving radiation and Viscum album L.: a real-world data study
Authors: Schad Friedemann , Steinmann Diana , Oei Shiao Li , Thronicke Anja , Grah Christian 
Published: March 2023

Abstract
Background
Lung cancer (LC) is associated with high mortality and poor quality of life (QoL). The disease as well as oncological treatments such as radiation and chemotherapy with adverse effects can impair the QoL of patients. Add-on treatment with extracts of Viscum album L. (white-berry European mistletoe, VA) has been shown to be feasible and safe and to improve the QoL of cancer patients. The aim of this study was to analyze the changes in QoL of LC patients being treated with radiation according to oncological guidelines and add-on VA treatment in a real-world setting.

Methods
A real-world data study was conducted using registry data. Self-reported QoL was assessed by the evaluation of the European Organization of Research and Treatment Health-Related Quality of Life Core Questionnaire scale (EORTC QLQ-C30). Adjusted multivariate linear regression analyses were performed to analyze factors associated with changes in QoL at 12 months.

Results
A total of 112 primary LC patients (all stages, 92% non-small-cell lung cancer, median age 70 (ICR: 63–75)), answered the questionnaires at first diagnosis and 12 months later. Assessment of 12 months changes in QoL revealed significant improvement of 27 points for pain (p = 0.006) and 17 points for nausea/vomiting (p = 0.005) in patients who received combined radiation and VA. In addition, significant improvements of 15 to 21 points for role (p = 0.03), physical (p = 0.02), cognitive (p = 0.04), and social functioning (p = 0.04) were observed in guideline treated patients receiving no radiation but add-on VA.

Conclusions
Add-on VA therapy reveals supportive effects for the QoL of LC patients. Particularly in combination with radiation a significant reduction in pain and nausea/ vomiting has been observed.
Trial registration The study received ethics approval and was retrospectively registered (DRKS00013335 on 27/11/2017).
Association between serum S100A11 levels and glucose metabolism in diabetic process
Authors: Wu Yao , Wu Shaobo , Li Fang , Zeng Ting , Luo Xiaohe 
Published: March 2023

Abstract
Background
Diabetes mellitus (DM) is a prevalent non-communicable metabolic disease, and S100A11 is a newly identified gene closely related to metabolism. The association of S100A11 with diabetes is unclear. This study aimed to assess the relationship between S100A11 and markers of glucose metabolism in patients with different glucose tolerance and gender.

Methods
This study included 97 participants. Baseline data were obtained, and the serum levels of S100A11 and metabolic markers (glycated hemoglobin [HbA1c], insulin release test, and oral glucose tolerance test) were measured. Linear and nonlinear correlations between serum S100A11 levels and HOMA-IR, HOMA of β, HbA1c, insulin sensitivity index (ISI), corrected insulin response (CIR), and oral disposition index (DIo) were analyzed. The expression of S100A11 was also detected in mice.

Results
Serum S100A11 levels increased in patients with impaired glucose tolerance (IGT) of both genders. S100A11 mRNA and protein expression increased in obese mice. There were nonlinear correlations between S10011 levels and CIR, FPI, HOMA-IR, whole-body ISI in the IGT group. S100A11 was nonlinearly correlated with HOMA-IR, hepatic ISI, FPG, FPI, and HbA1c in the DM group. In the male group, S100A11 was linearly correlated with HOMA-IR and nonlinearly correlated with DIo (derived from hepatic ISI) and HbA1c. In the female population, S100A11 was nonlinearly correlated with CIR.

Conclusions
Serum S100A11 levels were highly expressed in patients with IGT and in the liver of obese mice. In addition, there were linear and nonlinear correlations between S100A11 and markers of glucose metabolism, demonstrating that S100A11 has a role in diabetes.
Trial registration ChiCTR1900026990
Influence of muscle volume on jumping performance in healthy male and female youth and young adults
Authors: Bchini Souhail , Hammami Nadhir , Selmi Taoufik , Zalleg Dalenda , Bouassida Anissa 
Published: March 2023

Abstract
Background
Sex differences that appear throughout puberty have a substantial impact on the training process. It remains unclear what effect these sex differences should have on how training programs are planned and performed and what objectives should be established for boys and girls of different ages. This study aimed to investigate the relationship between vertical jump performance and muscle volume based on age and sex.

Methods
One hundred eighty healthy males (n = 90) and females (n = 90) performed three different types of vertical jumps (VJ): squat jump (SJ), counter movement jump (CMJ), and counter movement jump with arms (CMJ with arms). We used the anthropometric method to measure muscle volume.

Results
Muscle volume differed across age groups. There were significant effects of age, sex, and their interaction on the SJ, CMJ, and CMJ with arms heights. From the age of 14–15, males exhibited better performances than females, and large effect sizes became apparent in the SJ (d = 1.09, P = 0.04), CMJ (d = 2.18; P = 0.001) and CMJ with arms (d = 1.94; P = 0.004). For the 20–22-year-old age group, there was a significant difference in VJ performance between males and females. Extremely large effect sizes became apparent in the SJ (d = 4.44; P = 0.001), CMJ (d = 4.12; P = 0.001) and CMJ with arms (d = 5.16; P = 0.001). When performances were normalized to the lower limb length, these differences persisted. After normalization to muscle volume, males exhibited better performance when compared to females. This difference persisted only for the 20–22-year-old group on the SJ (p = 0.005), CMJ (p = 0.022) and CMJ with arms (p = 0.016). Among male participants, muscle volume was significantly correlated with SJ (r = 0.70; p < 0.01), CMJ (r = 0.70; p < 0.01) and CMJ with arms (r = 0.55; p < 0.01).

Conclusions
The results indicate that muscle volume may be one of the major determining factors in sex differences in vertical jumping performance.
Rectal shedding of monkeypox virus in a patient coinfected with Chlamydia trachomatis and Neisseria gonorrhoeae: a case report
Authors: Desgranges Florian , Glampedakis Emmanouil , Christinet Vanessa , Encarnação Sara , Fernandes Cândida , Greub Gilbert , Opota Onya , Cavassini Matthias 
Published: March 2023

Abstract
Background
Infection by the monkeypox virus classically causes a cutaneous rash that is preceded by fever and lymph node swelling, as well as other nonspecific systemic symptoms. A recent outbreak occurred and spread in Europe and other regions, especially among patients who declare themselves as men who have sex with men. Current reports have shown that cutaneous lesions may be limited to the anogenital area. We report on a case of proctitis caused by monkeypox virus, without visible typical lesions of this virus.

Case presentation
A 29-year-old Caucasian male presented with a monkeypox virus proctitis that recurred after treatment for a documented Neisseria gonorrhoeae and Chlamydia trachomatis coinfection, likely acquired at the same time. The proctitis was preceded by fever and a swollen inguinal lymph node, and was associated with a hemorrhoid. The monkeypox virus polymerase chain reaction of a rectal swab documented high viral loads, although no typical lesion was visible. After resolution of the rectitis, the patient developed a single dermatome herpes zoster, despite the absence of usual risk factors. The patient evolved well without further specific treatment.

Conclusion
This case shows that monkeypox virus can be responsible for proctitis, without any typical lesion, along with the important rectal shedding of the virus. It raises the concern of contagion during anal intercourse through body fluids and gives further credit that monkeypox virus can be a sexually transmitted infection. This should prompt routine rectal screening in patients with proctitis accompanied by fever and swollen lymph nodes, and in patients who have a history of unprotected receptive anal sex, even in presence of other sexually transmitted infections, and especially during a monkeypox virus outbreak. The potential link between monkeypox virus infection and shingles warrants further investigations.
Research on alleviating nonlinear problem by data feature extraction and fusion based on DFT-spread
Authors: Li Yupeng , Li Lei , Zhang Yichao , Zhang Mingzhu , Wu Du , Li Qianqian , Wang Xiaocheng , Ding Xiaoming 
Published: March 2023

AbstractCoherent optical orthogonal frequency division multiplexing (CO-OFDM) system is susceptible to nonlinear effects because of its intrinsic high peak-to-average ratio (PAPR). In this paper, two methods based on discrete Fourier transform spread (DFT-S) are introduced to improve the nonlinear tolerance of CO-OFDM system by extracting and fusing data features, which extract the features of communication data and perform feature fusion to get the important significance of the data. The first one is based on the 2-ary amplitude shift keying (2-ASK) modulation and the Hermitian symmetry of DFT, and the other one is based on the advantages of selective mapping algorithm and characteristics of data subcarrier mapping mode which has a significant impact on PAPR. Simulation results show that compared with the traditional CO-OFDM and DFT-S CO-OFDM systems, the improved methods have better performance in terms of PAPR and BER.
Evaluation of visual food stimuli paradigms on healthy adolescents for future use in fMRI studies in anorexia nervosa
Authors: Dąbkowska-Mika Agnieszka , Steiger Ruth , Gander Manuela , Haid-Stecher Nina , Fuchs Martin , Sevecke Kathrin , Gizewski Elke Ruth 
Published: March 2023

Abstract
Background
Mostly, visual food stimuli paradigms for functional Magnetic Resonance Imaging are used in studies of eating disorders. However, the optimal contrasts and presentation modes are still under discussion. Therefore, we aimed to create and analyse a visual stimulation paradigm with defined contrast.

Methods
In this prospective study, a block-design fMRI paradigm with conditions of randomly altering blocks of high- and low-calorie food images and images of fixation cross was established. Food pictures were rated in advance by a group of patients diagnosed with anorexia nervosa to address the dedicated perception of patients with eating disorders. To optimize the scanning procedure and fMRI contrasts we have analysed neural activity differences between high-calorie stimuli versus baseline (H vs. X), low-calorie stimuli versus baseline (L vs. X) and high- versus low-calorie stimuli (H vs. L).

Results
By employing the developed paradigm, we were able to obtain results comparable to other studies and analysed them with different contrasts. Implementation of the contrast H versus X led to increased blood-oxygen-level-dependent signal (BOLD) mainly in unspecific areas, such as the visual cortex, the Broca´s area, bilaterally in the premotor cortex and the supplementary motor area, but also in thalami, insulae, the right dorsolateral prefrontal cortex, the left amygdala, the left putamen (p < .05). When applying the contrast L versus X, an enhancement of the BOLD signal was detected similarly within the visual area, the right temporal pole, the right precentral gyrus, Broca´s area, left insula, left hippocampus, the left parahippocampal gyrus, bilaterally premotor cortex and thalami (p < .05). Comparison of brain reactions regarding visual stimuli (high- versus low-calorie food), assumed to be more relevant in eating disorders, resulted in bilateral enhancement of the BOLD signal in primary, secondary and associative visual cortex (including fusiform gyri), as well as angular gyri (p < .05).

Conclusions
A carefully designed paradigm, based on the subject’s characteristics, can increase the reliability of the fMRI study, and may reveal specific brain activations elicited by this custom-built stimuli. However, a putative disadvantage of implementing the contrast of high- versus low-calorie stimuli might be the omission of some interesting outcomes due to lower statistical power.
Trial registration NCT02980120.
Cultural policies and urban transitions green politics, democracy in the time of the pandemic
Authors: Négrier Emmanuel 
Published: March 2023

AbstractUrban and Cultural transition refers to several levels, with the environmental one occupying the minds. This transition raises the question of a new politicization of culture, of which cities are the theater. We will illustrate this point in the first part. In the second part, we will discuss this first point by posing the hypothesis that the politicization of culture is not a cyclical but a structural phenomenon, and that it includes certain peculiarities that must be taken into account at the time of urban transition. On the other hand, there is a transition resulting from the pandemic situation that the world has endured for the past 2 years. It is no less crucial for cultural policies, and has already obvious implications for the relationship that polity has with cultural policies. This is the third point we will address.
Applications and prospects of cryo-EM in drug discovery
Authors: Zhu Kong-Fu , Yuan Chuang , Du Yong-Ming , Sun Kai-Lei , Zhang Xiao-Kang , Vogel Horst , Jia Xu-Dong , Gao Yuan-Zhu , Zhang Qin-Fen , Wang Da-Ping , Zhang Hua-Wei 
Published: March 2023

AbstractDrug discovery is a crucial part of human healthcare and has dramatically benefited human lifespan and life quality in recent centuries, however, it is usually time- and effort-consuming. Structural biology has been demonstrated as a powerful tool to accelerate drug development. Among different techniques, cryo-electron microscopy (cryo-EM) is emerging as the mainstream of structure determination of biomacromolecules in the past decade and has received increasing attention from the pharmaceutical industry. Although cryo-EM still has limitations in resolution, speed and throughput, a growing number of innovative drugs are being developed with the help of cryo-EM. Here, we aim to provide an overview of how cryo-EM techniques are applied to facilitate drug discovery. The development and typical workflow of cryo-EM technique will be briefly introduced, followed by its specific applications in structure-based drug design, fragment-based drug discovery, proteolysis targeting chimeras, antibody drug development and drug repurposing. Besides cryo-EM, drug discovery innovation usually involves other state-of-the-art techniques such as artificial intelligence (AI), which is increasingly active in diverse areas. The combination of cryo-EM and AI provides an opportunity to minimize limitations of cryo-EM such as automation, throughput and interpretation of medium-resolution maps, and tends to be the new direction of future development of cryo-EM. The rapid development of cryo-EM will make it as an indispensable part of modern drug discovery.
The relationship of the prevalence and severity of restless legs syndrome in primary Sjögren syndrome with insomnia status, anxiety, depression, and neuropathic pain
Authors: Aksoy Meliha Kasapoğlu , Ayar Koray , Yeşil Büşra , Hattatoğlu Tülay Dilara 
Published: March 2023

Abstract
Background and aims
In this study, we aimed to compare the prevalence of restless legs syndrome (RLS) between primary Sjögren syndrome (PSS) patients and the healthy population and investigate the relationships between RLS and insomnia status, anxiety, depression, neuropathic pain, and lower extremity pain. Our case-control study, included 55 patients aged 18–65 who were diagnosed with PSS based on the 2016 ACR/EULAR criteria and 60 healthy controls aged 18–65. The pain levels of the participants were evaluated using the pain DETECT Questionnaire, the lower-extremity visual analog scale, and an algometer, all participants were screened for fibromyalgia syndrome, and their psychiatric parameters were evaluated with the Beck Depression Inventory and the Beck Anxiety Inventory. Insomnia status was assessed using the Insomnia Severity Index. The cases in the PSS group with and without restless legs syndrome were compared.

Results
While the rate of RLS in the PSS group was 26.7%, that in the control group was found as 9%, and the difference between the two groups was significant (p < 0.05). The severity of RLS in the PSS group was found to be significantly higher in comparison to that in the control group (p < 0.05). The PSS group had significantly higher lower-extremity pain, fibromyalgia, insomnia, depression, anxiety, and pain scores, as well as a significantly higher mean number of painful points, than the control group (p > 0.05). In the results of the multivariate regression analysis, depression and insomnia scores were identified as independent predictors for the presence of RLS in PSS cases (p < 0.05).

Conclusions
We found the prevalence and severity of restless legs syndrome higher in the primary Sjögren syndrome patients compared to the healthy participants in the control group. We identified depression and insomnia as independent predictors of the presence of restless legs syndrome in primary Sjögren syndrome cases.
Integrative Scoring System for Survival Prediction in Patients With Locally Advanced Nasopharyngeal Carcinoma: A Retrospective Multicenter Study
Authors: Zhang Bin , Luo Chun , Zhang Xiao , Hou Jing , Liu Shuyi , Gao Mingyong , Zhang Lu , Jin Zhe , Chen Qiuying , Yu Xiaoping , Zhang Shuixing 
Published: March 2023

PURPOSETumor stage is crucial for prognostic evaluation and therapeutic decisions in locally advanced nasopharyngeal carcinoma (NPC) but is imprecise. We aimed to propose a new prognostic system by integrating quantitative imaging features and clinical factors.MATERIALS AND METHODSThis retrospective study included 1,319 patients with stage III-IVa NPC between April 1, 2010, and July 31, 2019, who underwent pretherapy magnetic resonance imaging (MRI) and received concurrent chemoradiotherapy with or without induction chemotherapy. The hand-crafted and deep-learned features were extracted from MRI for each patient. After feature selection, the clinical score, radiomic score, deep score, and integrative scores were constructed via Cox regression analysis. The scores were validated in two external cohorts. The predictive accuracy and discrimination were measured by the area under the curve (AUC) and risk group stratification. The end points were progression-free survival (PFS), overall survival (OS), and distant metastasis-free survival (DMFS).RESULTSBoth radiomics and deep learning were complementary to clinical variables (age, T stage, and N stage; all P < .05). The clinical-deep score was superior or equivalent to clinical-radiomic score, whereas it was noninferior to clinical-radiomic-deep score (all P > .05). These findings were also verified in the evaluation of OS and DMFS. The clinical-deep score yielded an AUC of 0.713 (95% CI, 0.697 to 0.729) and 0.712 (95% CI, 0.693 to 0.731) in the two external validation cohorts for predicting PFS with good calibration. This scoring system could stratify patients into high- and low-risk groups with distinct survivals (all P < .05).CONCLUSIONWe established and validated a prognostic system integrating clinical data and deep learning to provide an individual prediction of survival for patients with locally advanced NPC, which might inform clinicians in treatment decision making.