bluuebunny/crossref_metadata_2025_split huggingface dataset:
Parameter Identification in Three-phase Induction Motor Aided by Halton-Chaos-$\beta $-PSO Algorithm
Authors: Santana Gisele Alves , Martinez Cristiane A. Pendeza , Goedtel Alessandro , Martinez André Luís M. , Abrao Taufik 
Published: January 2023

Abstract
Evolutionary heuristic algorithms attempt to biologically emulate the adaptive evolutionary nature of living beings via different procedures. This work proposes new mechanisms for improving the performance-complexity tradeoff of the evolutionary Particle Swarm Optimization (PSO) algorithm applied to parameter estimation of a three-phase induction motor problem subject to the operational changing of motor parameters during its operation. The proposed variant, namely the Halton-Chaos-$\beta$-PSO algorithm, resolves the parameter estimation problem faster and with minor errors than the conventional PSO. An analytical-iterative-heuristic variant combining the augmented Lagrangian method (ALM) and PSO (ALPSO) demonstrated good performance-complexity trade-off, particularly under online operation, with instantaneous (on-fly) modification of the motor parameters. Additionally, the ALM combined with a quasi-Newton method and the PSO hybridization with the gravitational search algorithm (PSOGSA) was evaluated. The efficiency and effectiveness of the proposed hybrid analytical-iterative-heuristic methods are corroborated by extensive numerical simulation results, considering heuristic input parameters tuning, which have revealed a remarkable reduction in the error estimation values when the estimation procedure is deployed dynamically in real-time applications.
Volume Deformation and Hydraulic Conductivity Behavior of Sand-Bentonite Mixtures with Fiberglass Additives Under High Temperatures
Authors: GÜNERİ Esra , AKSOY Yeliz YÜKSELEN 
Published: January 2023

Abstract
The performance of energy geo-structures is also dependent on the surrounding soil properties in the presence of high temperatures or thermal cycles. Change in temperature may affect many engineering parameters of soils. Sand-bentonite mixtures or bentonite which are used as a buffer should keep their performance at design level for a long time.
Purpose: In order to improve engineering behavior of soils under high temperatures thermally durable materials can be used. Volume deformation and hydraulic conductivity behavior of 30% bentonite-70% sand mixtures in the presence of fiberglass additives were investigated.
Methods: Consolidation tests were performed at both room and high temperatures (80 °C), hydraulic conductivity tests were started at room temperature and temperature cycle (25-50-80°C) was applied.
Results:Fiberglass increased the amount of compression insignificantly under room temperature, whereas the total compression amount increased remarkably under high temperature. On the other hand, the hydraulic conductivity increased under high temperature with fiberglass additive.
Conclusions: Fiberglass added sand-bentonite mixtures can be used around energy structures as an alternative buffer material with high temperature resistance.
Development of an Individual Index of Social Vulnerability that Predicts Negative Healthcare Events: A Proposed Tool to Address Healthcare Equity in Primary Care Research and Practice
Authors: Haggerty Jeannie , Minotti Simona C. , Bouharaoui Fatima 
Published: January 2023

Abstract
Purpose
Socially disadvantaged patients may lack self-efficacy to navigate a complex health system making them vulnerable to healthcare inequity. We aimed to develop an Index of social vulnerability that predicts increased risk of negative healthcare events (e.g. emergency hospitalization), independent of chronic disease burden. The analysis illustrates the conceptual and practical steps leading to the development of a pragmatic Index of social vulnerability to limited healthcare self-efficacy.
Methods
Using data from a 3-year cohort of 2507 adult primary care patients in Québec (Canada), we applied two complementary structural equation modelling approaches - Partial Least Squares Path Modelling (PLS-PM) and Multiple indicators and Multiple Causes (MIMIC) modelling - to identify a minimal set of social characteristics that could be summed into an Index related to limited healthcare self-efficacy. We then used logistic regression to determine if the Index predicted: hospital emergency department use; hospital admissions; unmet need for care, and others. We privileged parsimony over explanatory capacity in our analytic decisions to make the Index pragmatic for epidemiologic and clinical use.
Results
The Individual Social Vulnerability Index is the weighted sum of five indicators: social support; educational achievement; financial status; limited language proficiency. The Index predicts increased likelihood of all negative healthcare outcomes except unmet need, with a clear threshold at Index ≥ 2. The effect is independent of chronic disease burden.
Conclusion
When social deficits outweigh social assets by two or more (Index ≥ 2), there is an increased risk of negative healthcare events beyond the risk attributable to poor health. The Index is a pragmatic tool to identify a minority of patients who will require additional support to receive equitable healthcare.
Localized cardiac metabolic trajectories and post-infectious metabolic sequelae in experimental Chagas disease
Authors: Liu Zongyuan , Ulrich Rebecca , Kendricks April , Wheeler Kate , Leão Ana Carolina , Pollet Jeroen , Bottazzi Maria Elena , Hotez Peter , Gusovsky Fabian , Jones Kathryn , McCall Laura-Isobel 
Published: January 2023

Abstract
Post-infectious conditions, where clinical symptoms fail to resolve even after pathogen clearance, present major health burdens. However, the mechanisms involved remain poorly understood. In Chagas disease (CD), caused by the parasite Trypanosoma cruzi, antiparasitic agents can clear T. cruzi but late-stage treatment does not improve clinical cardiac outcomes. In this study, we revealed differential metabolic trajectories of cardiac regions during T. cruzi infection, matching sites of clinical symptoms. Incomplete, region-specific, cardiac metabolic restoration was observed in animals treated with the antiparasitic benznidazole, even though parasites were successfully cleared. In contrast, superior metabolic restoration was observed for a combination treatment of reduced-dose benznidazole plus an immunotherapy (Tc24-C4 T. cruzi flagellar protein and TLR4 agonist adjuvant), even though parasite burden reduction was lower. Overall, these results provide a mechanism to explain prior clinical treatment failures in CD and to test novel candidate treatment regimens. More broadly, our results demonstrate a link between persistent metabolic perturbation and post-infectious conditions, with broad implications for our understanding of post-infectious disease sequelae.
Study on ammonia generation from digested sludge by subcritical water treatment
Authors: Kato Takahiro , Kojima K. , Sumikura M. , Kuroiwa Y. 
Published: January 2023

Abstract
Organic sludge has recently attracted attention as a renewable energy source. While the organic matter contained in sludge can be utilized as various renewable energy sources, its nitrogen component has limited use. In this study, subcritical water treatment was conducted to recover ammonia from digested sludge. While ammonia recovered via stripping is limited to soluble components, subcritical water treatment can convert solid components and dissolved organic nitrogen sludge into ammonia. Digested sludge was treated at several reaction temperatures, reaction pressures, treatment times, and oxygen ratios to determine the ammonia generation rate. Among the conditions tested in this study, an ammonium generation rate of 84.0% was obtained at 400 °C, 10 MPa, a treatment time of 5 min, and at an oxygen ratio of 1.2.
Induction of Cancer Cell Death by Apigenin: A Review on Different Cell Death Pathways
Authors: Amini Peyman , Moazamiyanfar Reza , Dakkali Mohammad Sedigh , Jafarzadeh Emad , Ganjizadeh Maryam , Rastegar-Pouyani Nima , Moloudi Kave , Khodamoradi Ehsan , Taeb Shahram , Najafi Masoud 
Published: January 2023

Abstract:Induction of cell death and inhibition of cell proliferation in cancer have been set as some of the main goals in anti-tumor therapy. Cancer cell resistance leads to less efficient cancer therapy, and consequently, to higher doses of anticancer drugs, which may eventually increase the risk of serious side effects in normal tissues. Apigenin, a nature-derived and herbal agent, which has shown anticancer properties in several types of cancer, can induce cell death directly and/or amplify the induction of cell death through other anti-tumor modalities. Although the main mechanism of apigenin in order to induce cell death is apoptosis, other cell death pathways, such as autophagic cell death, senescence, anoikis, necroptosis, and ferroptosis, have been reported to be induced by apigenin. It seems that apigenin enhances apoptosis by inducing anticancer immunity and tumor suppressor genes, like p53 and PTEN, and also by inhibiting STAT3 and NF-κB signaling pathways. Furthermore, it may induce autophagic cell death and ferroptosis by inducing endogenous ROS generation. Stimulation of ROS production and tumor suppressor genes, as well as downregulation of drug-resistance mediators, may induce other mechanisms of cell death, such as senescence, anoikis, and necroptosis. It seems that the induction of each type of cell death is highly dependent on the type of cancer. These modulatory actions of apigenin have been shown to enhance anticancer effects by other agents, such as ionizing radiation and chemotherapy drugs. This review explains how cancer cell death may be induced by apigenin at the cellular and molecular levels.
Anti-anxiety and Hypnotic Effects of Lawsonia inermis Hydroalcoholic Extract
Authors: Pourbagher-Shahri Ali Mohammad , Rakhshandeh Hassan , Sabahi Keyvan , Hosseini Mahmoud , Forouzanfar Fatemeh 
Published: January 2023

Background:
Sleep is a vital biological feature, and insomnia causes maladaptive physical and
psychological functions. The main flaws of current insomnia medications are significant side effects. A
suitable substitute can be herbal products. We aimed to evaluate the anti-anxiety, sleep-inducing, and -
prolonging effects of Lawsonia inermis extract and fractions in mice.

Methods:
Male albino mice were pretreated intraperitoneally (i.p.) with either three doses (40, 80, and
160 mg/kg) of L. inermis extract or n-butanol fraction (NBF), ethyl acetate fraction (EAF), and water
fraction (WF), 30 minutes before i.p. injection of 30 mg/kg pentobarbital. Sleep latency and duration of
sleep were recorded. For anxiolytic activity, elevated plus-maze (EPM) tests were used. Moreover, the
toxicity of the extract was determined in both in vivo and in vitro experiments.

Results:
L. inermis extract (160 mg/kg) significantly reduced sleep latency and increased sleep duration.
EAF at 160 mg/kg decreased sleep latency and increased sleep duration. Flumazenil reversed the hypnotic
effect of L. inermis extract (160 mg/kg). L. inermis extract (80, 160 mg/kg) increased the time spent and
the number of entries in the open arms of EPM. The tested extracts and fractions administration found no
adverse effects on PC12 cell viability. The LD50 was 2.4 g/kg.

Conclusion:
L. inermis extracts exhibit anxiolytic and hypnotic effects, probably modulating the GABAergic
system.
Is it the Time to Move Towards Coronary Computed Tomography
Angiography-Derived Fractional Flow Reserve Guided Percutaneous Coronary
Intervention? The Pros and Cons
Authors: Sharifkazemi Mohammadbagher , Hooshanginezhad Zahra , Zoroufian Arezou , Shamsa Kamran 
Published: January 2023

Abstract:
Coronary artery disease is the leading cause of mortality worldwide. Diagnosis is conventionally
performed by direct visualization of the arteries by invasive coronary angiography
(ICA), which has inherent limitations and risks. Measurement of fractional flow reserve (FFR) has
been suggested for a more accurate assessment of ischemia in the coronary artery with high accuracy
for determining the severity and decision on the necessity of intervention. Nevertheless, invasive
coronary angiography-derived fractional flow reserve (ICA-FFR) is currently used in less than
one-third of clinical practices because of the invasive nature of ICA and the need for additional
equipment and experience, as well as the cost and extra time needed for the procedure. Recent
technical advances have moved towards non-invasive high-quality imaging modalities, such as
magnetic resonance, single-photon emission computed tomography, and coronary computed tomography
(CT) scan; however, none had a definitive modality to confirm hemodynamically significant
coronary artery stenosis. Coronary computed tomography angiography (CCTA) can provide
accurate anatomic and hemodynamic data about the coronary lesion, especially calculating fractional
flow reserve derived from CCTA (CCTA-FFR). Although growing evidence has been published
regarding CCTA-FFR results being comparable to ICA-FFR, CCTA-FFR has not yet replaced
the invasive conventional angiography, pending additional studies to validate the advantages
and disadvantages of each diagnostic method. Furthermore, it has to be identified whether
revascularization of a stenotic lesion is plausible based on CCTA-FFR and if the therapeutic plan
can be determined safely and accurately without confirmation from invasive methods. Therefore,
in the present review, we will outline the pros and cons of using CCTA-FFR vs. ICA-FFR regarding
diagnostic accuracy and treatment decision-making.
A Randomized Controlled Trial of Whole-Body Vibration on Gait Ability and Balance among Older Hemodialysis Patients
Authors: Asahina Yuta , Sakaguchi Yusuke , Kajimoto Sachio , Hattori Koki , Oka Tatsufumi , Kaimori Jun-Ya , Kashihara Naoki , Isaka Yoshitaka 
Published: January 2023

Background
Gait abnormality is a serious problem among hemodialysis patients. Whole-body vibration is a simple exercise that induces sustained muscular contractions through mechanical vibrations. This training improved gait ability in older adults. We aimed to investigate the effect of whole-body vibration on balance and gait ability in older hemodialysis patients.

Methods
We conducted a 12-week, open-label, multicenter, randomized controlled trial of 98 hemodialysis patients, who were aged ≥65 years, from three dialysis centers in Japan. Those who had difficulty walking alone or dementia were excluded. Patients were randomly allocated to the whole-body vibration group or control group. The training was performed for 3 minutes thrice a week on dialysis days. The primary outcome was the Timed Up and Go test. The secondary outcomes were the single-leg stand test and 30-second chair stand test.

Results
The mean (SD) age of the participants was 76 (7) years. The mean (SD) Timed Up and Go test was 12.0 (6.6) and 11.8 (7.0) seconds in the whole-body vibration and control groups, respectively. During the 12-week study period, 6 (12%) of 49 patients in the whole-body vibration group and 3 (6%) of 49 patients in the control group dropped out. In the whole-body vibration group, 42 (86% of the randomly allocated patients) completed the training according to the protocol. The mean (SD) changes in the Timed Up and Go test were −1.1 (4.0) and −1.4 (4.4) seconds in the whole-body vibration and control groups, respectively (change, 0.3 seconds in the whole-body vibration group; 95% confidence interval, −1.4 to 2.0; P=0.71). The changes in the single-leg stand test and 30-second chair stand test did not differ significantly between groups. There were no musculoskeletal adverse events directly related to this training.

Conclusions
Whole-body vibration did not improve balance and gait ability.

Clinical Trial registry name and registration number:
Effect of Whole Body Vibration on Walking Performance in Elderly Hemodialysis Patients NCT04774731.
Tolvaptan for Children and Adolescents with Autosomal Dominant Polycystic Kidney Disease
Authors: Mekahli Djalila , Guay-Woodford Lisa M. , Cadnapaphornchai Melissa A. , Greenbaum Larry A. , Litwin Mieczyslaw , Seeman Tomas , Dandurand Ann , Shi Lily , Sikes Kimberly , Shoaf Susan E. , Schaefer Franz 
Published: January 2023

Background
Tolvaptan slows expansion of kidney volume and kidney function decline in adults with autosomal dominant polycystic kidney disease (ADPKD). Progression during childhood could be treated before irreversible kidney damage occurs, but trial data are lacking. We evaluated the safety and efficacy of tolvaptan in children/adolescents with ADPKD.

Methods
This was the 1-year, randomized, double-blind, portion of a phase 3b, two-part trial being conducted at 20 academic pediatric nephrology centers. Key eligibility criteria were ADPKD and eGFR ≥60 ml/min per 1.73 m2. Participants aged 12–17 years were the target group (group 1, enrollment goal n≥60); participants aged 4–11 years could additionally enroll (group 2, anticipated enrollment approximately 40). Treatments were tolvaptan or placebo titrated by body weight and tolerability. Coprimary end points, change from baseline in spot urine osmolality and specific gravity at week 1, assessed inhibition of antidiuretic hormone activity. The key secondary end point was change in height-adjusted total kidney volume (htTKV) to month 12 in group 1. Additional end points were safety/tolerability and quality of life. Statistical comparisons were exploratory and post hoc.

Results
Among the 91 randomized (group 1, n=66; group 2, n=25), least squares (LS) mean reduction (±SEM) in spot urine osmolality at week 1 was greater with tolvaptan (−390 [28] mOsm/kg) than placebo (−90 [29] mOsm/kg; P<0.001), as was LS mean reduction in specific gravity (−0.009 [0.001] versus −0.002 [0.001]; P<0.001). In group 1, the 12-month htTKV increase was 2.6% with tolvaptan and 5.8% with placebo (P>0.05). For tolvaptan and placebo, respectively, 65% and 16% of subjects experienced aquaretic adverse events, and 2% and 0% experienced hypernatremia. There were no elevated transaminases or drug-induced liver injuries. Four participants discontinued tolvaptan, and three discontinued placebo. Quality-of-life assessments remained stable.

Conclusions
Tolvaptan exhibited pharmacodynamic activity in pediatric ADPKD. Aquaretic effects were manageable, with few discontinuations.

Clinical Trial registry name and registration number:
Safety, Pharmacokinetics, Tolerability and Efficacy of Tolvaptan in Children and Adolescents With ADPKD (Autosomal Dominant Polycystic Kidney Disease) NCT02964273.
Rapid Progression of Focal Segmental Glomerulosclerosis in Patients with High-Risk APOL1 Genotypes
Authors: Kallash Mahmoud , Wang Yujie , Smith Abigail , Trachtman Howard , Gbadegesin Rasheed , Nester Carla , Canetta Pietro , Wang Chen , Hunley Tracy E. , Sperati C. John , Selewski David , Ayoub Isabelle , Srivastava Tarak , Mottl Amy K. , Kopp Jeffrey , Gillespie Brenda , Robinson Bruce , Chen Dhruti , Steinke Julia , Twombley Katherine , Reidy Kimberly , Mucha Krzysztof , Greenbaum Larry A. , Blazius Brooke , Helmuth Margaret , Yonatan Peleg , Parekh Rulan S. , Hogan Susan , Royal Virginie , D'Agati Vivette , Chishti Aftab , Falk Ronald , Gharavi Ali , Holzman Lawrence , Klein Jon , Smoyer William , Kretzler Matthias , Gipson Debbie , Kidd Jason M. ,   on behalf of CureGN*
Published: January 2023

Background
FSGS is a heterogeneous diagnosis with a guarded prognosis. Polymorphisms in the apolipoprotein L1 (APOL1) gene are associated with developing FSGS and faster progression to kidney failure in affected patients. Better understanding the natural history of patients with FSGS and APOL1 risk alleles is essential to improve patient care and support the design and interpretation of interventional studies. The objective of this study was to evaluate the quantitative association between APOL1 and kidney disease progression and the interaction with other clinical and laboratory factors.

Methods
CureGN cohort study participants with biopsy diagnosis of FSGS, regardless of self-identified race, were included. The exposure of interest was two APOL1 risk alleles (high risk) versus zero to one risk alleles (low risk). The primary outcome was eGFR slope categorized as rapid progressor (eGFR slope ≤−5 ml/min per year), intermediate progressor (slope between 0 and −5), or nonprogressor (slope ≥0). Multivariable ordinal logistic and linear regressions were used for adjusted analyses. Missing data were addressed using multiple imputation.

Results
Of 650 participants, 476 (73%) had genetic testing, among whom 87 (18%) were high risk. High-risk participants were more likely to have lower median eGFR (62 [interquartile range, 36–81] versus low-risk participants 76 ml/min per 1.73 m2 [interquartile range, 44–106]; P<0.01). In adjusted analysis, the odds of more rapid progression of eGFR was 2.75 times higher (95% confidence interval, 1.67 to 4.53; P<0.001) in the high-risk versus low-risk groups.

Conclusions
In patients with FSGS, high-risk APOL1 genotype is the predominant factor associated with more rapid loss of kidney function.
Kedudukan Notaris Yang Mengambil Cuti Karena Diangkat Menjadi Anggota Legislatif
Authors: Vigo Putra Astra , Rahmi Elita , Abu Bakar Firdaus 
Published: January 2023

The duty of a notary as a public official is to serve the public concerned. As a servant, of course, a very noble task borne by a Notary. By referring to the UUJN which is actually a regulation that regulates his position, according to the author, it does not violate the law if it overrides the election law regarding concurrent positions. And also no party will be harmed if a Notary who is a member of the DPR applies for leave, in other words it does not stop. Notaries are required to apply for leave, and appoint a substitute Notary as stated in Article 11 paragraph (1-3) of the UUJN if the Notary is elected as a member of the Legislature. Because based on Article 17 letter d of the UUJN, a Notary is prohibited from serving as a state official. Regarding the request for leave due to being appointed as a State Official, the MPP must have received it within a maximum period of 60 (sixty) days from the date the decision as a State Official is stipulated. Before a Notary submits an application for leave, the mechanism in applying for a Notary leave that needs to be done first is to apply for a Leave certificate to the Directorate General of AHU Online. The request for leave must be received by the Regional Supervisory Council, Regional Supervisory Council, or Central Supervisory Council at the latest 30 (thirty) days before the leave is implemented, unless there are other valid reasons.
AbstrakÂ
Tugas Notaris sebagai pejabat umum ialah melayani masyarakat yang berkepentingan. Sebagai pelayan, tentunya sangat mulia tugas yang dipikul oleh Notaris. Dengan mengacu terhadap UUJN yang notabene sebuah peraturan yang mengatur akan jabatannya, menurut penulis tidak melanggar hukum apabila mengesampingkan Undang-undang pemilu soal rangkap jabatan. Dan juga tidak ada pihak yang dirugikan apabila Notaris yang menjadi anggota DPR mengajukan cuti, dengan kata lain tidak berhenti. Notaris wajib mengajukan cuti, dan menunjuk Notaris pengganti seperti yang disebutkandalamPasal 11 ayat (1-3) UUJN apabilaNotaris terpilih menjadi anggota Legislatif. Karena berdasarkan Pasal 17 huruf d UUJN Notaris di larangrangkap jabatan menjadi pejabat negara. Mengenai permohonan cuti karena diangkat menjadi Pejabat Negara harus sudah diterima MPP dalam jangka waktu paling lama 60 (enam puluh) hari sejak tanggal keputusan sebagai Pejabat Negara ditetapkan. Sebelum Notaris mengajukan permohonan cuti, mekanisme dalam pengajuan cuti Notaris yang perlu dilakukan terlebih dahulu ialah mengajukan permohonan sertifikat Cuti kepada Direktorat Jendral AHU Online. Permohonan cuti sudah harus diterima oleh Majelis Pengawas Daerah, Majelis Pengawas Wilayah, atau Majelis Pengawas Pusat dalam jangka waktu paling lambat 30 (tiga puluh) hari sebelum cuti dilaksanakan, kecuali ada alasan lain yang sah.
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