bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimization of production process scheduling at Mataram Convection using the Campbell-Dudek and Smith method and the Ho and Chang method
Authors: Yunus Muhammad Ahladi , Marwan Marwan , Alfian Muhammad Rijal 
Published: April 2023

Konveksi Mataram (Djagoan Kaos dan Seragam) is one of the industries engaged in the manufacture of various types of clothing models with fabric as the basic material. So far, the scheduling method used by the company is the First Come First Serve method, in which the completion of production is based on order-to-order data. In this case, with high order intensity, companies often experience difficulties in completing orders according to a predetermined pick-up time. The problems experienced by the company were caused by the production process scheduling that was not optimal. Based on the problems encountered, the purpose of this research is to obtain the optimal scheduling sequence by determining the smallest makespan (minimum total completion time) of the application of the method to the production process. The methods used in this study are the Campbell-Dudek and Smith method and the Ho and Chang method and from these two methods, it is known that the smallest production process is optimal. Based on the results of calculations using the Campbell-Dudek and Smith method, the optimal scheduling sequence with the smallest makespan is 39163 minutes or the production process will be completed in 73 working days. While the results of calculations using the Ho and Chang method obtained the optimal scheduling sequence with the smallest makespan of 38660.50 minutes or the production process will be completed in 72 working days. From the makespans of the two methods, the Ho and Chang method is superior to the Campbell-Dudek and Smith method with a difference of 502.50 minutes or about 1 working day, whereas when compared to the company's initial method, namely First Serve First Come with a makespan of 43025.50 minutes, the HC method can make completion time efficient with a difference of 4365 minutes or about 8 working days.
Keywords: Campbell-Dudek and Smith methods, first come first serve, Ho and Chang, makespan, production schedulingMSC2020: 90B30
Life Insurance Performance Characteristics
Authors: Raja Bouzouita  
Published: April 2023

This study examines the different factors that affect the profitability of the U.S. life insurance industry. Using a panel data from 1997 to 2013 for all U.S. life insurance companies, I find that company specific variables and macroeconomic indicators are statistically significant determinants of financial performance. Most notably, the statistical analysis shows that efficiency and market share are important determinants of life insurers’ profitability in addition to growth in GDP and interest rate. There is support for the profit persistency hypothesis that previous profitability significantly affects current performance of life insurance companies. Robustness tests by insurer’s organization type provide consistent results.
Assessing the Change in Operative Treatment Rates for Acute Midshaft Clavicle Fractures
Authors: Sepehri Aresh , Guy Pierre , Roffey Darren M. , O’Brien Peter J. , Broekhuyse Henry M. , Lefaivre Kelly A. 
Published: April 2023

Background:
In 2007, a randomized controlled trial (RCT) by the Canadian Orthopaedic Trauma Society (COTS) demonstrated better functional outcomes and a lower proportion of patients who developed malunion or nonunion following operative, compared with nonoperative, treatment of midshaft clavicle fractures. The primary aim of the present study was to compare the proportion of midshaft clavicle fractures treated operatively prior to and following the publication of the COTS RCT. An additional exploratory aim was to assess whether the proportion of midshaft clavicle fractures that were treated with surgery for malunion or nonunion decreased.

Methods:
This retrospective cohort analysis used population-level administrative health data on the residents of British Columbia, Canada. Cases were identified by International Classification of Diseases, Ninth Revision (ICD-9) diagnostic codes and procedure fee codes. Adult patients (≥18 years) with closed middle-third clavicle fractures between 1997 and 2018 were included. Multivariable logistic regression modeling compared the proportion of clavicle fractures treated operatively before and after January 1, 2007, controlling for patient factors. The Pearson chi-square test compared the proportion of fractures treated operatively for malunion or nonunion in the cohorts.

Results:
A total of 52,916 patients were included (mean age, 47.5 years; 65.6% male). More clavicle fractures were treated operatively from 2007 onward: 6.9% compared with 2.2% prior to 2007 (odds ratio [OR] = 3.35, 95% confidence interval [CI] = 3.03 to 3.70, p < 0.001). Male sex, moderate-to-high income, and younger age were associated with a greater proportion of operative fixation. The rate of surgery for clavicle malunion or nonunion also increased over this time period (to 4.1% from 3.4%, OR = 1.26, 95% CI = 1.15 to 1.38, p < 0.001).

Conclusions:
We found a significant change in surgeon practice regarding operative management of clavicle fractures following the publication of a Level-I RCT. With limited high-quality trials comparing operative and nonoperative management, it is important that clinicians, health-care institutions, and health-authority administrations determine what steps can be taken to increase responsiveness to new clinical studies and evidence-based guidelines.

Level of Evidence:
Prognostic Level III. See Instructions for Authors for a complete description of levels of evidence.
High-intensity functional training modulates oxidative stress and improves physical performance in adolescent male soccer players: A randomized controlled trial
Authors: Niknam Alireza , Gaeini Abbasali , Hamidvand Amin , Jahromi Maryam Koushkie , Oviedo Guillermo Ruben , Kordi Mohammadreza , Safarpour Farzaneh 
Published: April 2023

Abstract
Regular exercise training can decrease oxidative stress (OS) and up-regulate antioxidant functions in adult population. However, limited data exists considering OS responses in the pediatric population. The aim of this study was to investigate the effect of high-intensity functional training (HIFT) on the OS and performance in adolescent soccer players. In this randomized controlled trial, 20 adolescent soccer players (male, well-trained) were randomly divided into high intensity functional training (HIFT, n=10) and moderate intensity soccer technical training (MITT, n=10) groups. HIFT and MITT was performed for 8 weeks (3 days/week). Baseline OS biomarkers (MDA, 8-OHDG, H2O2, GPx and CAT) and physical performance (VO2peak, vertical jump height (VJH) and maximal explosive power (MEP)) were assessed before and after the intervention. Repeated measure mixed ANOVA (2×2) with a significance level of P<0.05 was used to determine differences between and within subjects. The main effect of interaction was significant for VO2peak, VJH and MEP (P<0.05). The main effect of interaction was not significant for CAT, 8-OHDG, GPx, H2O2 and MDA (P>0.05). Following intervention, VO2peak and VJH performance in the HIFT were significantly higher than MITT (P<0.05). MDA and H2O2 in the HIFT decreased significantly (P<0.05), but no significant changes were observed in the MITT (P>0.05). CAT activity decreased significantly (P<0.05), while GPx activity increased significantly (P<0.05) in both groups. 8-OHDG did not show significant changes in both groups (P>0.05). 8 weeks of HIFT did not cause greater OS compared to MITT, while could improve physical performance parameters.
Trial registration: The present study was a randomized controlled trial (registration number: IRCT20190530043762N1, 25/09/2019, Iran)
Thyroid dysfunction induced by anti-PD-1 therapy is associated with a better progression-free survival in patients with advanced carcinoma
Authors: Lu Yiran , Li Qingchen , Xu Lusi , Sun Ying , Zheng Yanqing , Wang Yanchao , Liu Ying , Zhang Rui , Liao Lin , Dong Jianjun 
Published: April 2023

Abstract
Purpose
Immune checkpoint inhibitors are associated with immune-related adverse events. Thyroid dysfunction during anti-programmed cell death 1(anti-PD-1) therapy remains to be fully characterized and mechanism underlying this complication and effects on patient prognosis remain unclear.
Methods
Patients with advanced carcinoma treated with anti-PD-1 therapy were evaluated for thyroid function at baseline and after treatment initiation from August 2020 to March 2022. Seventy-three patients were finally included in the study.
Results
Among these patients, 19 (26.03%) developed thyroid dysfunction after receiving anti-PD-1 therapy. Primary hypothyroidism and thyrotoxicosis were the most common clinical manifestation. Anti-PD-1 induced thyroid dysfunction occurred 63 (26-131) days after administration, thyrotoxicosis appeared earlier than primary hypothyroidism. In Kaplan–Meier survival analysis, the progression-free survival (PFS) of the thyroid dysfunction group was better than that of the non-thyroid dysfunction group (227 (95% confidence interval (CI): 50.85-403.15) days vs 164 (95% CI: 77.76-250.24) days, p=0.026). Male patients had better PFS than female patients (213 (95% CI: 157.74-268.26) days vs 74 (95% CI: 41.23-106.77) days, p=0.031). In cox proportional hazards regression model, anti-PD-1 induced thyroid dysfunction remained an independent predictor of better PFS (Hazard ratio (HR)=0.339(0.136-0.848), p=0.021).
Conclusion
Thyroid dysfunction is a common immune-related adverse events in advanced cancer patients treated with anti-PD-1 therapy and predicts a better prognosis. This study was retrospectively registered with Trial ClinicalTrials.gov (NCT05593744) on October 25, 2022.
The human pathome shows sex and tissue specific aging patterns
Authors: Scheibye-Knudsen Morten , Ezra Michael Ben , Garbrecht Jonas , Rasmussen Nasya , Heckenbach Indra , Petr Michael , Bakula Daniela , Mortensen Laust 
Published: April 2023

Abstract
Little is known about tissue specific changes that occur with aging in humans. Using the description of 33 million histological samples we extract thousands of age- and mortality-associated features from text narratives that we call The Human Pathome (pathoage.com). Notably, we can determine when pathological aging starts at the organism and tissue level, indicating a sexual dimorphism with females aging earlier but slower and males aging later but faster. We employ unsupervised topic-modelling to identify terms and themes that predict age and mortality. As a proof of principle, we cross reference these terms in PubMed to identify nintedanib as a potential aging intervention and show that nintedanib reduces markers of cellular senescence, reduces pro-fibrotic gene pathways in senescent cells and extends the lifespan of fruit flies. Our findings pave the way for expanded exploitation of population datasets towards discovery of novel aging interventions.
Antibody-antibiotic conjugate targeted therapy for orthopedic implant-associated intracellular S. aureus infections
Authors: qin leilei , Hu Ning , Zhang Yanhao , Yang Jianye , Zhao Liqun , Zhang Xiaokai , Yang Yun , Zhang Jinyong , Zou Yinshuang , Wei Keyu , Zhao Chen , Chen Li , Li Yujian , Chen Cheng , Chen Hong , Zeng Hao , Huang Wei , Zou Quanming 
Published: April 2023

Abstract
Background The treatment of orthopedic implant-associated infections, especially those caused by S. aureus, is extremely difficult. The ability of S. aureus to enter cells provides a means for it to evade antibiotics and immune responses during infection, and explains the clinical failure after antibiotic treatment. Therefore, it is critical to identify the host cell type of implant-associated intracellular S. aureus infections and to develop a strategy for highly targeted delivery of antibiotics to the host cells.Methods We introduced an antibody-antibiotic conjugate (AAC) for targeted elimination of intracellular S. aureus. The antibody component of AAC consisted of A human monoclonal antibody (M0662) against the surface antigen Staphylococcal protein A (SpA) of S. aureus. This antibody and vancomycin are conjugated by a cathepsin-sensitive linker, which cleaves in the proteolytic environment of intracellular phagolysosomes, thereby allowing vancomycin to perform its bactericidal action. We then tested the effect of AAC on intracellular S. aureus clearance by in vitro cell experiments and a mice implant infection model.Results In the implant infection model, AAC significantly improved the bactericidal effect of vancomycin. Scanning electron microscopy showed that the application of AAC effectively blocked the formation of bacterial biofilm without obvious toxicity to the host. Further histochemical and micro-CT analysis showed that AAC effectively reversed the imbalance between osteoblasts and osteoclasts and reduced bone loss around the knee joint under infection.Conclusions The application of AAC can effectively avoid the infection spread and recurrence caused by Staphylococcus aureus intracellular infection, which has the application prospect of clinical treatment of orthopedic implant infection.
Climate Change Related Litigation in Indonesia: The Dawn of a New Beginning?
Authors: Sulistiawati Linda Yanti 
Published: April 2023

Abstract

This study found that in Indonesia, 112 climate change related litigation cases have been brought to court between 2010 and 2020. This includes all cases using ‘climate change’ as key words in their main claim, argument, evidence, expert witness’ argument, and judgments. Climate change has been cited at all levels (District, Appellate, and Supreme Court) of criminal, and civil law. These cases are regarded as incidental climate change related litigations. This study opines that these cases are important in the development of climate change litigation in Indonesia as they opened a discussion of climate change issues in the Indonesian courts. Thus, this study identifies relevant criminal and civil climate change related litigation cases between 2010 and 2020 in Indonesia, and examines what factors drive climate change related litigation there.
Establishment of a prediction model of ferroptosis-related genes for overall survival risk in hepatocellular carcinoma and bioinformatic analysis of the novel gene FLT3
Authors: Cui Dapeng , Li Ming , Fu Runjia , Sun Zhongshuai , Li Zhao , Guo Wei , Fei Jiandong 
Published: April 2023

Abstract

Objective: Hepatocellular carcinoma (HCC) is a malignant tumor caused by malignant transformation of cells in the liver. It is the most common type of chronic liver cancer in adults. Ferroptosis has been found to play a key role in many tumor suppressions, but its prognostic value and key factors in hepatocellular carcinoma need to be further explored.Methods: We downloaded the RNAseq data and corresponding clinical information of HCC patients from TCGA database and ICGC database. The differential expression analysis and survival analysis of ferroptosis-related genes in tumor and normal tissues were carried out by R software. Univariate and multivariable cox regression analysis and the least absolute shrinkage and selection operator (LASSO) regression algorithm were used to build a overall survival (OS) risk prediction model for HCC in TCGA cohort, which was verified in ICGC cohort. The “immunedeconv” and "GSVA" packages were used to explore the important roles of single genes in HCC.Results: We successfully built a prediction model of 12 ferroptosis-related genes for overall survival risk in HCC, and confirmed the validity of the prediction model in the ICGC cohort. In addition, FLT3 gene was significantly associated with multiple pathways such as HCC tumor inflammation, Apoptosis, inflammatory response, and PI3K-AKT-mTOR.Conclusions: Ferroptosis plays a key role in the prognosis and treatment of primary HCC, and the prediction model of 12 ferroptosis-related genes for OS risk in HCC has significant effects. The ferroptosis-related gene FLT3, as a key immune-related factor, may become a new prognostic biomarker and a potential target for the treatment of HCC.
WITHDRAWN: Are Egyptian Students' Entrepreneurial Behaviours Affected by University Ecosystems?
Authors: Ead Hamed , Elbadry Abdullah M. M. 
Published: April 2023

Abstract
This study investigates the impact of university ecosystems on the entrepreneurial behaviours of Egyptian students. The research is based on a survey of 151 students from public and private higher education institutions in Egypt, using a standard questionnaire comprising ten items and demographic questions. Our findings reveal that entrepreneurship education has a positive influence on the entrepreneurial aspirations of students, as they become more willing to pursue entrepreneurship in the future. Furthermore, we examine the role of the academic environment in shaping the relationship between entrepreneurship training and the entrepreneurial motivations of students. This research builds upon the work of Ead et al. (1–6), which examined the entrepreneurship program being taught to university students in Egypt and the factors that contribute to their willingness to engage with it. The results of this study can provide valuable insights for decision-makers, faculty members, and professionals in Egyptian universities, helping them to understand the impact of university ecosystems on the entrepreneurial behaviours of students. Moreover, this study contributes to the existing empirical research on the benefits of entrepreneurship education in the context of Egyptian higher education institutions, offering a nuanced understanding of how university ecosystems can drive or impede student entrepreneurship.
The Effects of Sensory Integration Interventions on Automatic Reinforcement Behaviors in Children with Autism Spectrum Disorders: A Single Subject Study
Authors: Pi Yueming , Ma Ying , Wang Tingzhao 
Published: April 2023

Abstract
Background Identifying successful interventions for children with persistent behaviors maintained by automatic reinforcement is quite challenging.Methods This study analyzed the effects of interventions based on sensory integration (SI) on the automatic reinforcement behavior of two preschool boys with Autism Spectrum Disorders(ASD). First, we performed a functional analysis to determine whether the challenging behaviors were maintained by automatic reinforcement. Next, two sensory integration intervention assessments were used to identify the sensory disorders of the participants’ automatic reinforcement behaviors. Finally, this study implemented a sensory integration-based intervention and an adopted A-B-A-B design to verify the effectiveness of the intervention.Results The functional analysis results revealed that the participants’ target behaviors were maintained through automatic reinforcement. The findings suggested that the sensory integration-based intervention, which was designed depending on the results of the functional analysis and sensory integration assessments, positively affected the levels of automatic reinforcement behavior.Conclusions This study demonstrated that an intervention strategy based on the sensory integration theory had considerable effects on the automatic reinforcement behaviors of two preschool children.In the future, parents and professional therapists could apply this model for improving sensory integration disorders in children with ASD.
Three-dimensional finite element analysis of the influence of different surgical methods on the stress of meniscus and patellofemoral joint in the treatment of episodic patellar dislocation
Authors: Biao Xu , Tan Lu 
Published: April 2023

Abstract
BACKGROUND: At present, there are many surgical methods for the treatment of episodic patellar dislocation, and it is still unclear which surgical method can provide appropriate meniscus and patellofemoral joint stress.
OBJECTIVE: To explore the influence of different surgical methods simulating episodic patellar dislocation in three-dimensional finite element software on the stress of knee meniscus and patellofemoral joint surface under different flexion conditions.
METHODS: Acquire the knee joint CT and MRI of patients with episodic patellar dislocation and import them into Mimics and Geomagic to extract the model, then use Soildworks to complete the 0 °, 30 °, 60 °, 90 ° and 120 °buckling construction of the model, for each model, medial patellofemoral ligament reconstruction, medial retinaculum plication, lateral retinaculum release, medial patellofemoral ligament combined with medial patellotibial ligament reconstruction, medial patellofemoral ligament reconstruction combined with lateral retinaculum release be operation respectively.Finally, the model is imported into the mechanical software Ansys for biomechanical analysis, and the stress results of knee meniscus and patellofemoral joint surface are output.
RESULTS : The medial patellofemoral ligament combined with medial patellotibial ligament reconstruction has the smallest meniscus stress compared with other methods. The medial patellofemoral ligament combined with medial patellotibial ligament reconstruction and the medial patellofemoral ligament reconstruction combined with the lateral retinaculum release have smaller stress on the patellofemoral joint surface compared with the other three methods.
CONCLUSION :The medial patellofemoral ligament combined with medial patellotibial ligament reconstruction can provide well patellofemoral contact stress and meniscus stress, effectively restore the stability of the knee joint, and delay the purpose of joint and cartilage degeneration.Medial patellofemoral ligament reconstruction combined with lateral retinaculum release can also provide better patellofemoral joint stress, but the meniscus stress is slightly higher, so we should be alert to the complications related to the meniscus after surgery.Due to the high stress between patellofemoral joints and meniscus, the medial patellofemoral ligament reconstruction should prevent the risk of redislocation and the high incidence of patellofemoral osteoarthritis.
Revealing the nano-scale mechanisms of the limited non-basal plasticity in magnesium
Authors: Oh Sang Ho , Jeong Jiwon , Xie Zhuocheng , Alfreider Markus , Korte-Kerzel Sandra , Kiener Daniel , Guénolé Julien 
Published: April 2023

Abstract
⟨c+a⟩ dislocations are considered as the primary defects limiting the ductility of magnesium. It is argued that in small magnesium crystals the glide of such dislocations can be activated to accommodate plastic strain at high flow stress levels that are rarely achieved in the bulk. Here, we report ⟨c+a⟩ dislocation-mediated small-scale plasticity of c-axis oriented submicrometer-sized magnesium pillars observed by in situ transmission electron microscopy compression tests. After mobile ⟨c+a⟩ dislocations accommodate the initial plasticity of pillars, interactions between dislocations develop local dislocation entanglements, thereby preventing consecutive dislocation glide and surface annihilation. Supported by atomistic simulations, this increased pinning and multiplication is attributed to the formation of basal I1 and I2 stacking faults, induced by interaction of glissile pyramidal II dislocations, which serve as anchor points for dislocation sources. The ensuing plastic strain is accommodated via dislocation avalanches caused by simultaneous activation of multiple dislocation sources at increasing stress levels, forming a dislocation forest of ⟨c+a⟩ dislocations in the confined volume. This observation distinctly differs to common small-scale plasticity associated with a dislocation starved or exhausted state and provides a new concept towards plasticity and work hardening in bulk Mg.