bluuebunny/crossref_metadata_2025_split huggingface dataset:
What does the future look like for kelp when facing multiple stressors?
Authors: Wear Brigitte , O'Connor Nessa E. , Schmid Matthias J. , Jackson Michelle C. 
Published: June 2023

AbstractAs primary producers and ecosystem engineers, kelp (generally Order Laminariales) are ecologically important, and their decline could have far‐reaching consequences. Kelp are valuable in forming habitats for fish and invertebrates and are crucial for adaptation to climate change by creating coastal defenses and in providing key functions, such as carbon sequestration and food provision. Kelp are threatened by multiple stressors, such as climate change, over‐harvesting of predators, and pollution. In this opinion paper, we discuss how these stressors may interact to affect kelp, and how this varies under different contexts. We argue that more research that bridges kelp conservation and multiple stressor theory is needed and outline key questions that should be addressed as a priority. For instance, it is important to understand how previous exposure (either to earlier generations or life stages) determines responses to emerging stressors, and how responses in kelp scale up to alter food webs and ecosystem functioning. By increasing the temporal and biological complexity of kelp research in this way, we will improve our understanding allowing better predictions. This research is essential for the effective conservation and potential restoration of kelp in our rapidly changing world.
Long‐term community shifts driven by local extinction of an iconic foundation species following an extreme marine heatwave
Authors: Montie Shinae , Thomsen Mads S. 
Published: June 2023

AbstractGradual ocean warming combined with stronger marine heatwaves (MHWs) can reduce abundances of foundation species that control community structures, biodiversity, and ecosystem functioning. However, few studies have documented long‐term succession trajectories following the more extreme events that cause localized extinctions of foundation species. Here, we documented long‐term successional changes to marine benthic communities in Pile Bay, New Zealand, following the Tasman 2017/18 MHW, which caused localized extinctions of dominant southern bull kelp (Durvillaea sp.). Six years on, multiscale annual and seasonal surveys show no sign of Durvillaea recolonization. Instead, the invasive annual kelp (Undaria pinnatifida), rapidly colonized areas previously dominated by Durvillaea, followed by large changes to the understory community, as Durvillaea holdfasts and encrusting coralline algae were replaced by coralline turf. Between 3 and 6 years after the total loss of Durvillaea, smaller native fucoids colonized in high densities. Although Undaria initially colonized plots throughout Durvillaea's tidal range, later in the succession Undaria only retained dominance in the lower intertidal zone and only in spring. Ultimately, the tidal zone was slowly replaced by alternative foundation species, composed of different canopy‐forming brown seaweeds that dominated different intertidal elevations, resulting in a net increase in canopy and understory diversity. This study is a rare example of long‐term effects following an extreme MHW that caused extinctions of a locally dominant canopy‐former, but these events and their associated dramatic changes to community structures and biodiversity are expected to become increasingly common as MHWs continue to increase in strength, frequency, and duration.
The impact of fingolimod on Treg function in brain ischaemia
Authors: Malone Kyle , Shearer Jennifer A. , Waeber Christian , Moore Anne C. 
Published: June 2023

AbstractFingolimod has generally shown neuroprotective effects in stroke models. Here, we tested the hypothesis that fingolimod modulates T‐cell cytokine production towards a regulatory phenotype. Second, we investigated how fingolimod altered the Treg suppressive function and the sensitivity of effector T cells to regulation. Mice that had underwent the permanent electrocoagulation of the left middle cerebral artery received saline or fingolimod (0.5 mg/kg) daily for 10‐days post‐ischaemia. Fingolimod improved neurobehavioural recovery compared to saline control and increased Treg frequency in the periphery and brain. Tregs from fingolimod‐treated animals had a higher expression of CCR8. Fingolimod increased the frequencies of CD4+IL‐10+, CD4+ IFN‐γ+ and CD4+IL‐10+IFN‐γ+ cells in spleen and blood, and CD4+ IL‐17+ cells in the spleen, with only minor effects on CD8+ T‐cell cytokine production. Treg from post–ischaemic mice had reduced suppressive function compared to Treg from non‐ischaemic mice. Fingolimod treatment rescued this function against saline‐treated but not fingolimod‐treated CD4+ effector T cells. In conclusion, fingolimod seems to improve the suppressive function of Treg post‐stroke while also increasing the resistance of CD4+ effector cells to this suppression. Fingolimod's capacity to increase both effector and regulatory functions may explain the lack of consistent improvement in functional recovery in experimental brain ischaemia.
Molecular versus Silica‐Supported Iridium Water Oxidation Catalysts
Authors: Trotta Caterina , Menendez Rodriguez Gabriel , Tensi Leonardo , Yakimov Alexander V. , Rocchigiani Luca , Donnadio Anna , Zuccaccia Cristiano , Copéret Christophe , Macchioni Alceo 
Published: June 2023

AbstractA stringent comparison between two pairs of molecular/immobilized water oxidation catalysts ([Cp*Ir(Me‐pica)Cl], 1, versus 1_SiO2, Me‐pica=κ2‐N‐methyl‐picolinamide; [Cp*Ir(pysa)NO3], 2, versus 2_SiO2, pysa=κ2‐pyridine‐2‐sulfonamide]) reveals distinctive catalytic trends. While the molecular compound 1 exhibits a substantial higher activity than the analogous immobilized system 1_SiO2, under all the experimental conditions explored, the contrary is found with 2 that is far less active than its immobilized counterpart 2_SiO2. This is explained by the unique tendency of 2 to form dimeric complexes [Cp*Ir‐(κ2‐μ2‐Hpysa)(κ2‐μ2‐pysa)IrCp*], 2 a, in phosphate buffered solution at pH 7, and [Cp*Ir‐(κ2‐μ2‐Hpysa)2IrCp*], 2 b, in water. 2 a and 2 b have been completely characterized in solution by multinuclear and multidimensional NMR spectroscopy. They have been also isolated as single crystals and their structure in solid state determined by X‐Ray diffractometry. 2 a and 2 b appear to be off‐cycle species, whose formation is detrimental for water oxidation activity, as indicated by the observation of a long induction period when 2 a is used as catalytic precursor. In addition, TOF versus ΔE (E−E0=−RT/nF ln([IO4−]/[IO3−]) trends for the first two runs do not overlap for catalyst 2 and TOFmax is remarkably higher in the second run upon the addition of fresh NaIO4. In the immobilized system 2_SiO2 the detrimental associative processes are likely inhibited leading to an activity higher than that of 2.
Synthesis, Structures, and Luminescent Properties of Chloride and Nitrate LnIIIComplexes Coordinated by tris(Pyrazolyl)methane
Authors: Lyubov Dmitry M. , Mahrova Tatyana V. , Cherkasov Anton V. , Fukin Georgy K. , Fedorov Yury V. , Trifonov Alexander A. 
Published: June 2023

AbstractWe report the synthesis of Ln3+nitrate [Ln(Tpm)(NO3)3] ⋅ MeCN (Ln=Yb (1Yb), Eu (1Eu)) and chloride [Yb(Tpm)Cl3] ⋅ 2MeCN (2Yb), [Eu(Tpm)Cl2(μ‐Cl)]2(2Eu) complexes coordinated by neutral tripodal tris(3,5‐dimethylpyrazolyl)methane (Tpm). The crystal structures of1Lnand2Lnwere established by single crystal X‐ray diffraction, while for1Ybhigh resolution experiment was performed. Nitrate complexes1Lnare isomorphous and both adopt mononuclear structure. Chloride2Ybis monomeric, while Eu3+analogue2Euadopts a binuclear structure due to two μ2‐bridging chloride ligands. The typical lanthanide luminescence was observed for europium complexes (1Euand2Eu) as well as for terbium and dysprosium analogues ([Ln(Tpm)(NO3)3] ⋅ MeCN, Ln=Tb (1Tb), Dy (1Dy); [Ln(Tpm)Cl3] ⋅ 2MeCN, Ln=Tb (2Tb), Dy (2Dy)).
PCCP‐Catalyzed Synthesis of Tetrasubstituted Allenes Bearing Heteroaromatic Sulfenyl Group**
Authors: Kamlar Martin , Císařová Ivana , Veselý Jan 
Published: June 2023

AbstractWe report a Brønsted acid‐catalyzed synthesis of tetrasubstituted allenyl compounds decorated with heterocyclic sulfenyl group. The reaction proceeds readily from available propargylic alcohols in the presence of pentacarboxycyclopenatadienes (PCCPs) as organocatalysts. The developed strategy provides tetrasubstituted allene derivatives in high yields (from 55 to 98 %) and under mild reaction conditions.
Lactobacillus salivarius and Lactobacillus gasseri supplementation reduces stress‐induced sugar craving in mice
Authors: Nicol Marion , Lahaye Emilie , El Mehdi Mouna , do Rego Jean‐Luc , do Rego Jean‐Claude , Fetissov Serguei O. 
Published: June 2023

AbstractObjectiveIncreased intake of sweets or sugar craving may occur in response to chronic stress representing a risk factor for development of eating disorders and obesity. However, no safe treatment of stress‐induced sugar craving is available. In this study we analysed effects of two Lactobacillus strains on food and sucrose intake in mice before and during their exposure to a chronic mild stress (CMS).Research Methods & ProceduresC57Bl6 mice were gavaged daily for 27 days with a mix of L. salivarius (LS) LS7892 and L. gasseri (LG) LG6410 strains or with 0.9% NaCl as a control. Following 10 days of gavage, mice were individually placed into the Modular Phenotypic cages, and after 7 days of acclimation were exposed to a CMS model for 10 days. Food, water and 2% sucrose intakes as well as meal pattern were monitored. Anxiety and depressive‐like behaviour were analysed by standard tests.ResultsExposure of mice to CMS was accompanied by increased size of sucrose intake in the control group likely reflecting the stress‐induced sugar craving. A consistent, about 20% lower total sucrose intake, was observed in the Lactobacilli‐treated group during stress which was mainly due to a reduced number of intakes. Lactobacilli treatment also modified the meal pattern before and during the CMS, showing a decrease of meal number and an increase of meal size with a tendency of reduced total daily food intake. Mild anti‐depressive behavioural effects of the Lactobacilli mix were also present.ConclusionSupplementation of mice with LS LS7892 and LG LG6410 decreases sugar consumption suggesting a potential utility of these strains against stress‐induced sugar craving.
Comparison of regmed and BayesNetty for exploring causal models with many variables
Authors: Howey Richard , Cordell Heather J. 
Published: June 2023

AbstractHere we compare a recently proposed method and software package, regmed, with our own previously developed package, BayesNetty, designed to allow exploratory analysis of complex causal relationships between biological variables. We find that
regmed generally has poorer recall but much better precision than BayesNetty. This is perhaps not too surprising as
regmed is specifically designed for use with high‐dimensional data. BayesNetty is found to be more sensitive to the resulting multiple testing problem encountered in these circumstances. However, as
regmed is not designed to handle missing data, its performance is severely affected when missing data is present, whereas the performance of BayesNetty is only slightly affected. The performance of
regmed can be rescued in this situation by first using BayesNetty to impute the missing data, and then applying
regmed to the resulting “filled‐in” data set.
Prevalence and correlates of high‐dose opioid use among survivors of head and neck cancer
Authors: Nugent Shannon M. , Slatore Christopher G. , Winchell Kara , Handley Robert , Clayburgh Daniel , Chandra Ravi , Hooker Elizabeth R. , Knight Sara J. , Morasco Benjamin J. 
Published: June 2023

AbstractBackgroundWe characterized prescription opioid medication use up to 2 years following the head and neck cancer (HNC) diagnosis and examined associations with moderate or high daily opioid prescription dose.MethodsUsing administrative data from Veterans Health Administration, we conducted a retrospective cohort analysis of 5522 Veterans treated for cancers of the upper aerodigestive tract between 2012 and 2019. Data included cancer diagnosis and treatments, pain severity, prescription opioid characteristics, demographics, and other clinical factors.ResultsTwo years post‐HNC, 7.8% (n = 428) were receiving moderate or high‐dose opioid therapy. Patients with at least moderate pain (18%, n = 996) had 2.48 times higher odds (95% CI = 1.94–3.09, p < 0.001) to be prescribed a moderate opioid dose or higher at 2 years post diagnosis.ConclusionsSurvivors of HNC with at least moderate pain were at elevated risk of continued use of moderate and high dose opioids.
Multiple memory systems for efficient temporal order memory
Authors: Jafarpour Anna , Lin Jack J. , Knight Robert T. , Buffalo Elizabeth A. 
Published: June 2023

AbstractWe report distinct contributions of multiple memory systems to the retrieval of the temporal order of events. The neural dynamics related to the retrieval of movie scenes revealed that recalling the temporal order of close events elevates hippocampal theta power, like that observed for recalling close spatial relationships. In contrast, recalling far events increases beta power in the orbitofrontal cortex, reflecting recall based on the overall movie structure.
Go with the flow: An experimental analysis with tubing alternative with irrigation
Authors: Hyland Scott S. , DeGenova Daniel T. , Taylor Benjamin C. , Scheschuk Joseph P. 
Published: June 2023

AbstractBackground and AimsLiterature regarding alternative tubing for fluid delivery in irrigation and debridement procedures is lacking. The purpose of this study was to compare three different apparatuses with varying quantities of irrigation fluid to assess efficiency of administration and evaluate overall time for fluid administration.MethodsThis model was designed to compare available methods of gravity irrigation used in practice. Fluid flow time was measured for three types of tubing: single‐lumen cystoscopy tubing, Y‐type double‐lumen cystoscopy tubing, and nonconductive suction tubing. Irrigation times were assessed for varying volumes of 3, 6, and 9 L to investigate the relationship between bag changes and irrigation time. Bag changes were not conducted for the 3 L trial, but were for 6 and 9 L trials. Dimensions of cystoscopy tubing consisted of 4.95 mm internal diameter and 2.1 m length in both single‐lumen and Y‐type double‐lumen apparatus. Nonconduction suction tubing dimensions were 6.0 mm internal diameter and standard 3.7 m in length.ResultsThe mean flow time for suction tubing was significantly faster than the cystoscopy tubing for the 3 and 9 L trials (p < 0.001). At 6 L, flow time for the suction tubing and the double lumen cystoscopy tubing were similar, 264 versus 260 s, respectively. At 9 L, the mean flow time for the suction tubing was 80 s faster (410 vs. 491 s) compared with single‐lumen cystoscopy and was nearly 30 s faster compared with Y‐type cystoscopy tubing.ConclusionThe results of this study provide insight into a faster, widely available, and cost‐efficient alternative to commonly used cystoscopy tubing.
Factors influencing mobile banking adoption in India: The role of government support as a mediator
Authors: Saxena Noopur , Gera Navneet , Taneja Mayur 
Published: June 2023

AbstractThis study aims to objectively examine the factors influencing mobile banking adoption in India. There has been a model put forth that is founded on the unified theory of acceptance and use of technology and technology readiness. Data was collected from 536 mobile banking users. The primary determinants influencing mobile banking adoption were assessed using structural equation modeling. The study's conclusions indicate that the most significant predictors of behavioral intention to use mobile banking are factors such as performance expectancy, effort expectancy, social influence, optimism, and innovativeness. The relationship between users' behavioral intentions and adoption of mobile banking is partially mediated by government support. With the help of this study, mobile banking service providers in urban India will be better able to develop new services or modify current ones to boost the adoption of mobile banking.
US Departments of Pharmacy practice single terminal‐degree tenure‐track scholarly activity
Authors: Chao Darin , Zhu Julia , Tak Casey , Kim Kibum , Henkels Rebecca , Munger Mark A. 
Published: June 2023

AbstractIntroductionBibliometric analysis of publications is a valuable tool for quantification of academic productivity and impact. United States (US) Departments of pharmacy practice scholarship by tenure‐track (DPP‐TT) faculty is vital for future evolution of the field.ObjectivesTo quantify journal and faculty metrics based on scholarly activity among US DPP‐TT faculty over a 10‐year period.MethodsA search of PubMed was performed of single terminal‐degree DPP‐TT faculty from January 01, 2010 to 31 December, 2019. DPP‐TT faculty housed in DPP were determined through online published faculty rosters in American Association Colleges of Pharmacy rosters or college/school internet sites. For each DPP‐TT faculty publication, the journal name, journal impact factor (JIF), and number of citations were collected. DPP‐TT faculty members' Hirsch index (h‐index) and National Institutes of Health iCite weighted relative citation ratio (RCR) value were determined. Descriptive statistics and analysis of variance were used to compare data across demographic strata.ResultsOne hundred and thirty‐seven institutions employed 1805 single terminal‐degree pharmacy practice faculty that produced 12 670 (7.0 ± 16.3/10 years/faculty member) publications. The number of citations/publications was (mean ± standard deviation [SD]) 24.7 ± 80.8 cited most frequently in medicine, pharmacy education, and drug therapy journals with a JIF of 4.7 ± 11.5. Individual faculty members' h‐index was 6.5 ± 8.9 with a mean iCite weighted RCR of 22.1 ± 65.3. Individual metrics increased with academic rank progression (p < 0.0001).ConclusionThese national single terminal‐degree DPP‐TT faculty metrics are similar to other healthcare professions, including publishing in high‐quality medicine, pharmacy education, and drug therapy journals.
Blockade of P2X7 receptor‐mediated purinergic signaling with A438079 protects against LPS‐induced liver injury in rats
Authors: Kara Adem , Ozkanlar Seckin 
Published: June 2023

AbstractThe study aimed to investigate the hepatoprotective effects of purinergic receptor (P2X7R) antagonism by A438079 in liver damage. An experimental model of inflammation was performed by intraperitoneal (i.p.) lipopolysaccharide (LPS) administration in the rat. The groups were Control, A438079, dimethyl sulfoxide (DMSO), LPS, LPS + DMSO, and LPS + A438079. Following LPS (8 mg/kg) injection, A438079 (15 mg/kg) and DMSO (0.1 mL) were administrated (i.p) in the study groups. The blood and the liver tissues were removed for histological, biochemical, and western blot analyses. In the biochemical analysis, serum aspartate transaminase (AST) and alanine transaminase (ALT) concentrations, the tissue glutathione (GSH) level, and superoxide dismutase (SOD) activity dramatically decreased and malondialdehyde (MDA) level increased in the LPS and LPS + DMSO groups compared to the LPS + A438079 group. In the histological analysis, severe sinusoidal dilatation, necrotic hepatocytes, and inflammatory cell infiltration were observed in the LPS and LPS + DMSO groups while these effects were lessened in the LPS + A438079 group. The relative protein expression levels of P2X7R, Nf‐kB‐p65, IL‐6, and Caspase‐3 were significantly higher in the LPS and the LPS + DMSO groups than in the LPS + A438079 group. On the other hand, these protein expressions were considerably lower in the Control, A438079, and DMSO groups compared to the LPS + A438079 group. In addition, Bcl‐2 protein expression was significantly lower in the LPS and the LPS + DMSO groups and higher in the LPS + A438079 group compared to the other groups. The protective effect of A438079 against LPS‐induced hepatic inflammation may be related to P2X7R antagonism, inflammatory mediators, and apoptotic cell death.
Detection of triclosan using 2‐domain hemoglobin promoter of Daphnia magna
Authors: Yu Jaeyoung , Shin Hwa‐Yoon , Vu Le Quynh Anh , Kim Yang‐Hoon , Min Jiho 
Published: June 2023

AbstractTriclosan has been widely used as an antimicrobial agent. However, triclosan was found to cause toxicity, including muscle contraction disturbances, carcinogenesis, and endocrine disorders. In addition, it was found to affect central nervous system function adversely and even have ototoxic effects. Conventional methods for detecting such triclosan can be performed easily. However, the conventional detection methods are inadequate in precisely reflecting the impact of toxic substances on stressed organisms. Therefore, a test model for the toxic environment at the molecular level through the organism is needed. From that point of view, Daphnia magna is being used as a ubiquitous model. D. magna has the advantages of easy cultivation, a short lifespan and high reproductive capacity, and high sensitivity to chemicals. Therefore, the protein expression pattern of D. magna that appear in response to chemicals can be utilized as biomarkers for detecting specific chemicals. In this study, we characterized the proteomic response of D. magna following triclosan exposure via two‐dimensional (2D) gel electrophoresis. As a result, we confirmed that triclosan exposure completely suppressed D. magna 2‐domain hemoglobin protein and evaluated this protein as a biomarker for triclosan detection. We constructed the HeLa cells in which the GFP gene was controlled by D. magna 2‐domain hemoglobin promoter, which under normal conditions, expressed GFP, but upon triclosan exposure, suppressed GFP expression. Consequently, we consider that the HeLa cells containing the pBABE‐HBF3‐GFP plasmid developed in this study can be used as novel biomarkers for triclosan detection.
The validity of a therapeutic invigoration task in avolitional schizophrenia outpatients
Authors: Dlagnekova Antonia , Van Staden Werdie 
Published: June 2023

AbstractBackground and ObjectivesAvolition is associated with much morbidity and functional impairment in schizophrenia patients. Vigor may be taken as, in part, the inverse of avolition, but it has not been investigated as a therapeutic pursuit before. To this end, a therapeutic invigoration task was developed drawing on cognitive‐behavioral and guided imagery therapies. This study investigated the validity and reliability of a therapeutic invigoration task in avolitional residual phase schizophrenia outpatients.MethodsIn a proof‐of‐concept quasi‐experimental one‐group sequentially repeated pretest/posttest study design, patients (n = 76) participated in a structured invigoration task that was repeated after 1 month (n = 70).ResultsPatients' vigor during the preceding 7 days measured on the Vigor Assessment Scale increased highly significantly in anticipation of the subsequent 7 days on both occasions with respectively very large (Cohen's δ with Hedges' correction [δ] = 1.46) and large (δ = 1.04) effect sizes. The anticipated vigor after the first occasion was partially consummated during the subsequent month in that vigor during the 7 days preceding the second occasion was lower than participants had anticipated but still significantly higher than at baseline (p < 0.001; δ = 0.70). Repeating the task a month later, together with homework, had a cumulative effect as indicated by a very large effect size (δ = 1.61).ConclusionResults suggest that the invigoration task did what it was supposed do, and did so consistently, in patients with avolitional residual schizophrenia. These results warrant a subsequent randomized controlled trial to establish the efficacy of the invigoration task.