bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dyke-Davidoff-Masson Syndrome (DDMS) in Adult: A Rare Case in Rural Area
Authors: Pramanasari Indra 
Published: February 2023

Highlight:

Dyke-Davidoff-Masson syndrome (DDMS) is an uncommon neurological disease defined as cerebral hemiatrophy with a contralateral motor deficit, facial asymmetry, and seizures.
The proper diagnosis and early causative treatment significantly improve the outcome of thee disease.

ABSTRACT
Introduction: Dyke-Davidoff-Masson syndrome (DDMS) could be a rare neurological disorder characterized by cerebral hemiatrophy and an engine shortfall on the contralateral side of the body. Furthermore, facial asymmetry and seizures are common symptoms. Classic imaging findings in individuals with DDMS are ventriculomegaly, cerebral hypoplasia, paranasal sinus hyperpneumatization, and compensatory osseous broadening. The relationship between symptoms and imaging findings is used to determine DDMS. Case: A 46-year-old female patient arrived at the hospital with an inability to speak three days before admission, refused to eat or drink, and had a fever. She also had a slanted mouth and right-sided hemiparesis with a history of seizures. A firm boundary consolidation on the right pericardium was found on the chest X-ray, suggesting pulmonary TB. On a non-contrast head CT scan, thickening of the left hemicalvaria was found, accompanied by a widening of the left frontal-ethmoidal sinus, hyperpneumatization of the left mastoid air cell, and left cerebral hemiatrophy, all accompanied by left lateral ventricular dilatation. Conclusion: The proper diagnosis and early causative treatment significantly improve the outcome of the disease.
Dendritic Cells as Adjuvant Therapy to Decrease Mortality for Glioblastoma Patients: Meta-Analysis
Authors: Rahmaditta Allyssa , Monica Ervin 
Published: February 2023

Highlight:

Dendritic cells (DC) are one type of immune therapy that is being explored to improve treatment effectiveness in glioblastoma multiforme (GBM).
DC was predicted to improve survival rates in GBM patients within 3 years.
Effects of DC in the fifth year need to be explored to prove their. effectiveness in increasing the GBM survival rate.

ABSTRACT
Introduction: Glioblastoma multiforme (GBM) is a primary neoplasm of the central nervous system with a low survival rate, requiring more effective treatment to improve long-term survival. Dendritic cell (DC) therapy is expected to reduce tumor progressivity. Obective: The purpose of this meta-analysis was to analyze the administration of DC in reducing mortality in GBM patients. Methods: A systematic literature search was conducted using the PRISMA method through the Embase database, PubMed, and the Cochrane Controlled Trials Register for relevant studies between giving DC to GBM patients with conventional therapy on the number of living patients compared to controls. Article quality was assessed using the Newcastle-Ottawa Scale and statistically analyzed using RevMan 5.4. Results: Of the 14 articles, the rates of reduction in the probability of death during the first three years after initiation of therapy were 26%, 36%, and 38%, respectively [1st-y HR: 0.74 (0.57-0.95), I2: 15%, p=0.02; 2nd-y HR: 0.64 (0.51-0.81), I2: 14%, p=0.0002; 3rd-y HR: 0.62 (0.48-0.81), I2: 0%, p=0.0004]. However, there was no difference after 5 years [HR 0.81 (0.62-1.06), I2: 0%, p=0.13]. Conclusion: The DC vaccine reduces the likelihood of death in the early years of therapy but has not been proven for long-term therapy.
Hemorrhagic Wallenberg Syndrome Accompanied by Horner Syndrome at Young Age
Authors: I Imran , Fadhila Lailatul 
Published: February 2023

Highlight:

Wallenberg syndrome caused by medulla oblongata hemorrhage with good functional outcome.
Wallenberg syndrome is accompanied by Horner's syndrome, which occurs at a young age.
In patients with Wallenberg syndrom, conservative management and medical rehabilitation are used.

ABSTRACT
Introduction: Wallenberg syndrome is a rare syndrome involving the medulla oblongata, an uncommon hemorrhage site. It is also known as lateral medullary syndrome or posterior inferior cerebellar artery syndrome. Wallenberg syndrome has several symptoms that can be divided into vestibulo-cerebellar, bulbar, autonomic, sensory, and atypical. Case: A 27-year-old man came to the emergency unit complaining of dizziness and swinging, as well as a left eyelid that did not open completely, a lack of sweat on the left side of the face, a hoarse voice, swallowing disturbances, hiccups, decreased hearing in the left ear, and a lack of sensation on the left side of the face and the right side of the body. The patient tended to fall to the left and was unsteady when standing. Physical examination revealed Horner syndrome, bidirectional nystagmus, left dysdiadochokinesia, and left ataxia. A CT scan of the head showed a left-sided medulla oblongata hemorrhage. The patient was given conservative therapy, feeding through a nasogastric tube, and medical rehabilitation. A repeat CT scan of the head was done one week later, and it was discovered that the hemorrhage in the medulla oblongata had begun to absorb. Conclusion: Wallenberg syndrome, with a manifestation of hemorrhagic stroke in the medulla oblongata, can occur at a young age with various clinical symptoms. The diagnosis of Wallenberg syndrome is made based on clinical symptoms and imaging findings. Conservative therapy using medicines and medical rehabilitation can provide a speedy recovery. An incorrect diagnosis is a major hazard to patient safety and can have serious consequences, including permanent disability or death.
Diffusion Weighted Imaging (DWI) Classification and Apparent Diffusion Coefficient (ADC) Value Tendency Based on Cerebral Glioma Grading in Patients at Dr. Soetomo General Academic Hospital in 2016-2020
Authors: Kurniawan Komang Wahyu , Utomo Sri Andreani , Wahyuhadi Joni 
Published: February 2023

Highlight:

Many studies conclude that the prognosis of gliomas can be determined using the DWI sequence and ADC value on MRI
The correlation between DWI and ADC values with glioma grading is related to tumor cellularity, nuclear-cytoplasmic ratio, and extracellular space, which affect the movement of water molecules.

ABSTRACT
Introduction: Glioma grading is crucial to know its prognosis. Magnetic resonance imaging (MRI) is used as a preoperative examination that contains diffusion-weighted imaging (DWI) sequences confirmed by an apparent diffusion coefficient (ADC) value that helps assess tissue based on water diffusion. Objective: To prove the relationship between DWI and ADC values with cerebral glioma grading in patients at Dr. Soetomo General Academic Hospital in 2016—2020. Methods: This retrospective study collected medical records and MRI files in DICOM (Digital Imaging and Communications in Medicine) format. Gender, age, tumor histopathology, and glioma grading were collected. DWI and ADC values were obtained using the RadiAnt DICOM Viewer application. The data were analyzed using descriptive and analytical statistics. The chi-square test was used to analyze the relationship of DWI with glioma grading, and the spearman rank test was used to analyze the relationship of ADC value with glioma grading. Results: The majority of 35 patients were male (54.3%), aged 31–40 years old (22.9%), and the most common histopathology was glioblastoma (37.1%), WHO grade IV. On DWI, most low-grade glioma (LGG) patients showed unrestricted diffusion, and most high-grade glioma (HGG) patients showed restricted diffusion. The ADC value of HGG was lower than the ADC value of LGG. Statistical tests showed a relationship between DWI and glioma grading (p<0.05) and a relationship between the ADC value and glioma grading (p<0.05). Conclusion: There was a relationship between DWI and ADC with glioma grading in Dr. Soetomo General Academic Hospital patients for the period 2016—2020
Life Cycle impacts assessment of two gold extraction systems in Colombia: Open-pit and alluvial mining
Authors: Londoño Natalia Cano , Capaz Rafael Silva , Hasenstab Christian , Velásquez Héctor I. , McIntyre Neil R. , Corder Glen D. , Posada John A. 
Published: February 2023

Abstract
Purpose

Gold mining has historically and significantly contributed to the Colombian economy. Gold extraction in Colombia is mainly done through two techniques: open-pit and alluvial mining. In this study, the environmental impacts of both these mining systems were analyzed using the Life Cycle Assessment (LCA) framework, including identification of the system components that contribute most to impacts.

Methods

Inventory data were obtained for two medium-scale mines1 in Colombia, one representing the open pit method and the other the alluvial method. Environmental impacts were classified and characterized by mid-point impact categories and further aggregated into end-point indicators through the ReCiPe (v. 1.11) methodology, which uses a hierarchist perspective.

Results

Results for end-point indicators show that the open-pit mining presents higher values in the Human Health damage category, influenced primarily by tailings and by the excavation process. For the alluvial mining, the overall impacts were an order of magnitude lower, with Ecosystem Quality as the most significant contributor due to the stripping of soil and vegetation. In the case of mid-point indicators, freshwater and marine ecotoxicity contribute the most to open-pit mining, while for alluvial mining, metal depletion and natural land transformation contribute the most. Climate change is also a significant impact category for alluvial and open-pit mining.

Conclusions

The is a substantial difference in environmental impacts between the two mining systems: the quantified total environmental impact was 1.0 x 1004 points for the open-pit mine and 2.4 x 1003 points for the alluvial mine. Since these mines represent specific Colombian operational conditions, this conclusion cannot be confidently extended to other operational contexts while. For example, results in other cases may depend on the local geological features and natural environment conditions. Knowing the critical mining supply chain stages for environmental performance will allow the decision-makers to provide the tools for more sustainable extraction and production.
1 The Colombian mining classification lies on small, medium, and big scale based on the number of hectares granted in the mining concession: small (≤150 ha), medium (≥150 ha, ≤5000 ha), big (≥ 5000 ha, ≤10000) or according with the volume of the maximum annual mining production small (≤250000 m3/year), medium (≥250000 m3/year, ≤1300000 m3/year), big (1300000≥m3/year), and not on the number of workers (Código de Minas, Ley 685 DE 2001, 2001)
Long-term Physical Activity Decreased the Risk of New-onset Hypertension in Type 2 Diabetes Mellitus Patients with Pre-hypertension: A Retrospective Cohort Study
Authors: Zhou Jianmei , Lv Xiaoling , Zhou Rongfang , Wang Bozhong , Wu Qing 
Published: February 2023

Abstract
Purpose This study was aimed to determine the impact of long-term physical activity (PA) on the risk of new-onset hypertension in type 2 diabetes mellitus (T2DM) patients with pre-hypertension.
Methods A total of 268 T2DM patients with pre-hypertension were recruited between January and December 2015, and followed them up until December 2020. All patients were took PA self-assessment. Demographic, clinical, laboratory, radiologic, treatments, complications, lifestyle and clinical outcomes data were extracted from electronic medical records or collected through a structured interview.
Results During 5 year follow-up, the prevalence of new-onset hypertension was significantly lower in PA group (15.5% vs 35.4%, p<0.01) when compared to the physical inactivity (PIA) group. Logistic regression analysis showed that PA (OR 0.337, 95%CI 0.168 to 0.677, p<0.01), body mass index (BMI) (OR 1.138, 95%CI 1.019 to 1.272, p<0.05) and glycosylated hemoglobin (HbA1C) (OR 1.206, 95%CI 1.006 to 1.446, p<0.05) were associated to the prevalence of new-onset hypertension in pre-hypertensive T2DM patients. Subgroup analysis found that for those overweight and poorly controlled pre-hypertensive T2DM patients, long-term PA were less likely to develop hypertension (overweight: OR 0.187, 95%CI 0.063 to 0.558, p<0.01; glycaemic glucose poor controlled: OR 0.349, 95%CI 0.138 to 0.880, p<0.05).
Conclusion These results suggested that long-term PA might be an important protective factor for new-onset hypertension in overweight and poor blood glycaemic controlled pre-hypertensive T2DM patients.
Trial registration at https://www.medicalresearch.org.cn/login (MR-33-22-021256, 30/11/2022)
Maternal Age at Childbirth and the Risk of Attention-Deficit/Hyperactivity Disorder and Learning Disability in Offspring
Authors: Gao Ling , Li Songtao , Yue Yulin , Long Guangfeng 
Published: February 2023

Abstract
Background: Studies have shown that young maternal age at childbirth can increase the risk of attention-deficit/hyperactivity disorder (ADHD) in offspring, but a study of the U.S. population has not been reported. Moreover, there is no reported research on young and advanced maternal age at childbirth and whether it can contribute to the risk of learning disability (LD) in offspring.
Methods: This study evaluated the association between young and advanced maternal age at childbirth and offspring risk of ADHD and LD in the U.S. population. Using data from 8,098 participants included in the National Health and Nutrition Examination Survey (NHANES) conducted in 1999–2004, we analyzed the association between maternal age at childbirth and ADHD and LD risk in offspring. Oddsratios (ORs) and 95% confidence intervals (CIs) for maternal age at childbirth in association with ADHD and LD risk in offspring were estimated using multivariate logistic regression models after adjustment for age, sex, race, body massindex (BMI), poverty income ratio, smoking status during pregnancy, and NHANES cycle. Restricted cubic spline (RCS) models were used to evaluate potential nonlinear relationships. Sensitivity analyses were performed to ensure the reliability of the results.
Results: Among all participants, the offspring of subjects with a maternal age at childbirth of 18–24 years had an increased risk of ADHD (OR=1.34, 95% CI: 1.01, 1.79) and LD (OR=1.36, 95% CI: 1.06, 1.79) or either ADHD or LD (OR=1.48, 95% CI: 1.20, 1.81). Additionally, compared with subjects with a maternal age at childbirth of 25–29 years, subjects with a maternal age at childbirth of 35–39 years had lower odds of having offspring with ADHD (OR=0.60, 95% CI: 0.36, 1.00) and higher odds of having offspring with LD (OR=1.34, 95% CI: 1.01, 1.78). The relationship between maternal age at childbirth and LD risk presented a U-shaped curve.
Conclusions: These results provide epidemiological evidence showing that young and advanced maternal age at childbirth are associated with ADHD and LD risk.
Economically viable electrocatalytic ethylene production with high yield and selectivity
Authors: Zhao Bo-Hang , Chen Fanpeng , Wang Mengke , Cheng Chuanqi , Wu Yongmeng , Liu Cuibo , Yu Yifu , Zhang Bin 
Published: February 2023

Abstract
Electrocatalytic semihydrogenation of acetylene provides a clean pathway to produce ethylene (C2H4), one of the most widely used petrochemical feedstocks, but its performance is still well below that of the thermocatalytic route, leaving its practical feasibility questionable. Here our techno-economic analysis shows that this process becomes profitable if the Faraday efficiency (FE) exceeds 85% at a current density of 0.2 A cm−2. As a result, we design a Cu nanoparticle catalyst with coordinatively unsaturated sites to steer the reaction towards these targets. Remarkably, our electrocatalyst synthesized on gas diffusion layer-coated carbon paper enables a high C2H4 yield rate of 70.15 mmol mg−1 h−1 and a FE of 97.7% at an industrially relevant current density of 0.5 A cm−2. Combined characterizations and calculations reveal that such performance can be attributed to a favorable combination of a higher energy barrier for coupling of active hydrogen atoms (H*) and weak absorption of *C2H4. The former serves to suppress the competitive hydrogen evolution reaction, whereas the latter avoids overhydrogenation and C-C coupling. Further life cycle assessment evidences the economic feasibility and sustainability of the process. Our work suggests a way towards rational design and manipulation of nanocatalysts that could find wider and greener catalytic applications.
Carbonic anhydrase IX inhibitor S4 triggers immunogenic cell death in glioma cells via endoplasmic reticulum stress pathway
Authors: Cui Jing , Xu Huizhe , Shi Ji , Fang Kun , Liu Jia , Liu Feng , Chen Yi , Liang Haiyang , Zhang Ye , Piao Haozhe 
Published: February 2023

Abstract
Background Immunogenic cell death (ICD), which releases danger-associated molecular patterns (DAMP) that induce potent anticancer immune response, has emerged as a key component of therapy-induced anti-tumor immunity. The aim of this work was to analyze whether the carbonic anhydrase IX inhibitor S4 can elicit ICD in glioma cells.
Methods The effects of S4 on glioma cell growth were evaluated using the CCK-8, clonogenic and sphere assays. Glioma cell apoptosis was determined by flow cytometry. Surface-exposed calreticulin (CRT) was inspected by confocal imaging. The supernatants of S4-treated cells were concentrated for the determination of HMGB1and HSP70/90 expression by immunoblotting. RNA-seq was performed to compare gene expression profiles between S4-treated and control cells. Pharmacological inhibition of apoptosis, autophagy, necroptosis and endoplasmic reticulum (ER) stress was achieved by inhibitors. In vivo effects of S4 were evaluated in glioma xenografts. Immunohistochemistry (IHC) was performed to stain Ki67 and CRT.
Results S4 significantly decreased the viability of glioma cells and induced apoptosis and autophagy. Moreover, S4 triggered CRT exposure and the release of HMGB1 and HSP70/90. Inhibition of either apoptosis or autophagy significantly reversed S4-induced release of DAMP molecules. RNA-seq analysis indicated that the ER stress pathway was deregulated upon exposure to S4. Both PERK-eIF2α and IRE1α- XBP1 axis were activated in S4-treated cells. Furthermore, pharmacological inhibition of PERK significantly suppressed S4-triggered ICD markers and autophagy. In glioma xerografts, S4 significantly reduced tumor growth.
Conclusions Altogether, these findings suggest S4 as a novel ICD inducer in glioma and might have implications for S4-based immunotherapy.
SSD with Multi-scale feature Fusion and Attention mechanism
Authors: Zeng Zhigao , Dong Lijun , Liu Qiang , Zhu Wenqiu , Zhu Yanhui , Meng Chen 
Published: February 2023

Abstract
In the Internet of Things, image acquisition equipment is very important, which will generate lots of invalid data when monitoring in real time. Analyzing the data collected from the terminal directly by edge calculation can remove invalid frames and improve the accuracy of system detection. SSD algorithm model is relatively light and fast detection speed. However, SSD algorithms don't take full advantage of both shallow and deep information, a multiscale feature fusion attention mechanism structure based on SSD algorithm was proposed in this paper, which combines the idea of multiscale feature fusion and attention mechanism. Improve the feature information expression ability by fusing adjacent feature layers for each detection layer. Then, add the attention mechanism to to improve the algorithm's attention to the feature map channels. The results of the experiment show that the optimized model detection accuracy is improved, which will greatly improve the reliability of edge calculation.
Single versus double blastocyst transfer in first and second frozen-thawed embryo transfer cycle in advance-aged women: a two-center retrospective cohort study
Authors: Zhou Yuxi , Ji Hui , Zhang Mianqiu , Zhang Juanjuan , Li Xin , Zhang Junqiang , Ling Xiufeng , Chen Li , Zhao Chun 
Published: February 2023

Abstract
Background
The present evidence is deficient for the trade-offs between the pros and cons of single blastocyst transfer (SBT) versus double blastocyst transfer (DBT) in frozen-thawed embryo transfer cycles for women in advanced reproductive age, especially in the second cycle. The current study aimed to investigate the impact of transferred blastocyst numbers on pregnancy outcomes in the first and second embryo transfer for women ≥ 35 years.
Methods
This was a retrospective cohort study including 1284 frozen-thawed blastocyst transfer (FBT) cycles from two reproductive centers. We analyzed the pregnancy outcomes after SBT and DBT in the first and second FBT cycles. Moreover, stratified analysis was conducted by maternal age.
Results
In the first FBT cycle, the LBR was higher in DBT group than that in the SBT group [52.3% vs. 33.9%; adjusted odds ratio (aOR), 1.65; 95% confidence interval (CI), 1.26–2.15, P < 0.001]. However, the LBR of the DBT group showed no remarkable difference compared with that of the SBT group in the second cycle of FBT (44.3% vs. 33.3%; aOR, 1.30; 95% CI, 0.81–2.08; P = 0.271). Furthermore, stratified analysis by age showed a higher LBR for the DBT group than the SBT group in patients aged 38–42 years (43.1% vs. 33.9%; aOR, 2.27; 95% CI, 1.05–4.90; P = 0.036).
Conclusions
The present study demonstrated that the SBT regimen is the best choice for both, the first and second frozen-thawed embryo transfer cycles, for women aged 35–37 years. Additionally, the DBT regimen is still recommended to achieve a high LBR in women aged 38–42 years in the second FBT cycle. These findings may be beneficial for deciding the embryo transfer regimens in women of advanced reproductive age.
Quality assessment of the Topo-Iberia CGPS stations and data quality's effects on ionosphere-free phase residuals
Authors: García-Armenteros Juan Antonio 
Published: February 2023

Abstract
GPS data from Topo-Iberia network spanning a period of almost 12 years (2008–2020) have been analyzed. Data quality information for all 26 Topo-Iberia stations is provided for the first time complementing the Spanish Geological Survey’s storage work. Analyses of data based on quality indicators obtained with TEQC have been carried out. Guidelines and data quality information from IGS stations have been taken as quality references. The results show that the Topo-Iberia stations have better or equal quality than more than half of IGS stations. The stations ALJI, EPCU, and TIOU stand out as the worst stations, and on the contrary FUEN, PALM, PILA, and TRIA meet the guidelines to become an IGS station. The relationship between GPS data quality and their GAMIT- and GipsyX-derived ionospheric-free phase residuals has also been studied, and the results reveal an inversely proportional relationship. It has been found that the stations showing an increase in elevation of the horizon line, also show an increase in cycle slips and multipath, are among the poorest quality stations, and among those with the highest root-mean-square of phase residuals. Moreover, the evolution of vegetation around the antenna should be considered as it could cause the progressive loss of quality, not complying with the IGS standards. The quality assessment carried out shows that the Topo-Iberia stations are appropriate for geodetic purposes, but a permanent monitoring would be necessary to avoid the least possible loss of data and quality.