bluuebunny/crossref_metadata_2025_split huggingface dataset:
ANALISIS KINERJA SIMPANG EMPAT TAK BERSINYAL (STUDI KASUS: SIMPANG EMPAT JL. PARIK PUTUIH)
Authors: Azwar Gunawan , Masril Masril , Kurniawan Deddy 
Published: June 2023

Bukittinggi merupakan sebuah kota di Provinsi Sumatera Barat yang disebut kota wisata. Bertambahnya pertumbuhan kendaraan berimbas pada jumlah volume lalu lintas melebihi kapasitas ruas jalan yang ada, dampaknya yaitu terjadinya konflik arus lalu lintas pada suatu jaringan jalan.Persimpangan yang mengalami konflik adalah simpang Jl. Parik Putuih yang merupakan simpang tak bersinyal berlengan empat. Simpang Jl. Parik Putuih terletak di perbatasan Kota Bukittinggi dengan Kabupaten Agam yang merupakan Jl. Lintas Sumatera atau Jl. Raya Batusangkar. Ruas jalan ini merupakan jalan keluar masuk lalu lintas dari dan menuju Kota Bukittinggi.Kesibukan lalu lintas ini sering terjadi pada ruas jalan dan persimpangan jalan, terutama pada pagi hari, siang hari dan sore hari dimana pelajar, mahasiswa, pekerja, pedagang, serta wisatawan menuju ketempat tujuannya atau menuju ke tempat aktivitasnya, dengan kata lain saat aktivitas pemakai jalan sangat tinggi, yang akan memperlambat pergerakan kendaraan.Penelitian menggunakan metode kuantitatif yaitu melakukan survey di lapangan. Yang mana dilakukan selama 3 hari kerja. Hasil yang didapatkan jam puncak kendaraan ramai yaitu pada hari Sabtu yang memiliki derajat kejenuhanya DS = 3,71 dengan hambatan samping tinggi dan mengalami tundaan rata-rata dijalan utama -1,76, dijalan simpang -2,75. Peluang antriannya juga tinggi yaitu 855,86% sampai 2730,14%. Kata kunci : Arus Lalu Lintas, Derajat Kejenuhan, Hambatan Samping, Simpang Tak Bersinyal, Tundaan, Peluang Antrian.
ANALISA STABILITAS TRANSIEN PADA JARINGAN DISTRIBUSI RADIAL IEEE 33 BUS TERHUBUNG DENGAN PLTMH PADA KONDISI OPERASI TERPISAH (ISLANDING OPERATION)
Authors: Febiola Shinta , Yulisman Yulisman , Yamashika Herris 
Published: June 2023

Kebutuhan akan energi listrik terus meningkat seiring dengan perkembangan teknologi dan pertambahan penduduk dan perkembangan beban yang terus meningkat. Salah satu cara untuk menjaga ketersediaan energi listrik yang mampu mengakomodasi perkembangan beban tanpa menambah kapasitas pembangkit utama adalah dengan menempatkan Distributed Generation (DG). Metode yang digunakan pada penelitian ini dengan menggunakan pembangkit tersebar PLTMH dalam menganalisa stabilitas transien pada jaringan distribusi radial IEEE 33 bus. Hasil yang paling baik dari beberapa simulasi yaitu pada penambahan 2 pembangkit tersebar pada bus 16 dan 27 yaitu semua nilai tegangan bus dalam keadaan normal dan mengurangi rugi-rugi daya totalnya menjadi 80,2 kw. Kata kunci : DG, Stabilitas Transien, Aliran Distribusi
TINJAUAN PERENCANAAN STRUKTUR ATAS KANTOR DINAS SOSIAL KOTA BUKITTINGGI
Authors: Sabnoveta Rezza Sabnoveta , Masril Masril , Kurniawan Deddy 
Published: June 2023

Banyaknya bangunan yang runtuh diakibatkan oleh kemampuan suatu struktur yang tidak mampu menahan beban yang bekerja, membuat kerugian harta benda dan bahkan jiwa yang tidak sedikit. Oleh karena itu dalam merencanakan rancangan suatu struktur bangunan harus benar-benar penuh ketelitian, perhitungan yang matang serta sesuai persyaratan-persyaratan dengan acuan Standar Nasional Indonesia (Peraturan Pembebanan Indonesia untuk Gedung dan Bangunan SNI-1727-2013). Penelitian ini bertujuan untuk merencanakan dimensi elemen struktur, perhitungan tulangan struktur. Adapun data-data elemen struktur yang digunakan adalah dari hasil desain pendahuluan (Preliminery Design). Dalam analisisnya dibantu program ETABS dengan pemilihan sistem struktur sistem jaringan (Grid System). Berdasarkan hasil perhitungan Preliminery design diperoleh data untuk penggunaan struktur atas lantai 1 sampai dengan lantai 3 dimana didapat penampang kolom induk ukuran 50x65 cm, balok induk ukuran 30x50 cm, balok anak ukuran 20x30 cm. Perencanaan pelat lantai dan juga dak beton yang dilakukan dengan Preliminery design didapatkan tebal 12 cm. Kata Kunci : Preliminery design, analisis ETABS, perhitungan tulangan.
ANALISIS FAKTOR PENYEBAB KECELAKAAN LALU LINTAS (STUDI KASUS: JALAN SIDANG TANGAH KM12, KECAMATAN MATUR KABUPATEN AGAM)
Authors: Yanti Rahma , Kurniawan Dedi 
Published: June 2023

Tingkat mobilitas yang tinggi menyebabkan meningkatnya kebutuhan terhadap sarana transportasi yang ekonomis dan yang dapat dihandalkan. Pada jalan Sidang Tangah KM 12 Kecamatan Matur Kabupaten Agam dapat kita jumpai kerusakan badan jalan yang cukup parah yaitu tidak ratanya permukaan jalan dan jalan berlubang sehingga sering terjadi kecelakaan. Menurut data dari Polres Agam, diperoleh informasi bahwa dalam lima tahun terakhir terjadi kecelakaan yang mengakibatkan kerugian harta benda sampai kehilangan nyawa. Dengan kondisi tersebut diperlukan upaya untuk mengetahui faktor faktor penyebab terjadinya kecelakaan lalu lintas dan upaya penanganan untuk mengurangi peristiwa kecelakaan. Langkah awal yang dilakukan adalah pencarian data primer yang dilakukan survey lapangan untuk mengetahui penyebab kecelakaan. Data sekunder didapat dari Polres Agam yaitu data jumlah kecelakaan tahun 2017-2021. Dari hasil analisis faktor-faktor penyebab kecelakaan diperoleh faktor manusia dalam kategori tertinggi dengan persentase rata-rata 56%. Dan dari hasil korelasi didapat jumlah korban yang diakibatkan oleh faktor manusia berkorelasi sangat kuat dengan nilai korelasi (r) 0.913, Dari hasil korelasi faktor kendaraan didapat nilai interpretasinya kuat yaitu (r) 0,612, Dari hasil korelasi faktor jalan didapat nilai interpretasinya kuat yaitu (r) 0,645, Dari hasil korelasi faktor lingkungan didapat nilai interpretasinya kuat yaitu (r) 0,667. Saran dari penelitian ini adalah dilakukan penanganan dan kesadaran manusia sebagai pengemudi maupun pejalan kaki perlu ditingkatkan. Kata kunci: kecelakaan lalu lintas, faktor kecelakaan dan korelasi
ANALISIS TINGKAT PELAYANAN ANGKUTAN KOTA PT TRANEX GPM RUTE BUKITTINGGI – PADANG
Authors: Lestary Desy , Ishak Ishak , Bastian Elfania 
Published: June 2023

Bukittinggi is one of the cities in West Sumatra and has the second largest economy in West Sumatra, Indonesia. Considering the growth and development of the city of Padang, most people use public transportation for trade, work and tourism. The population in this study were users of public transportation between cities on the Bukittinggi - Padang route. City transportation PT Tranex Graha Perkasa Mandiri has 8 fleets with executive class buses equipped with air conditioning, the number of passenger seats is 16 people with a sample of 97 respondents. The purpose of this study was to determine the performance of public transportation PT Tranex Graha Perkasa Mandiri and determine the level of service. Sampling technique is done by sampling technique. Data was collected by means of a questionnaire. 80% of the respondents surveyed the security conditions in the vehicle are safe or there are no disturbances, both criminal and passenger safety, while 20% of respondents stated that it was not safe. 55% of inter-city public transport vehicle passengers on the Bukittinggi - Padang route who were interviewed stated that the vehicle they were traveling in was moderate, while 30% said it was good and 15% said it was bad. Based on the results of the analysis, it is concluded that the waiting time for PT Tranex Graha Perkasa Mandiri is 60 minutes, which according to service standards is less and the waiting time is 30 minutes less in service standards. Keywords : City Transport, Bukittinggi, service, transportation
PERENCANAAN JALUR KHUSUS SEPEDA DI JALAN SAMUDERA KAWASAN WISATA PANTAI PADANG
Authors: Apriatul Hakki Aldi , Ishak Ishak , Dewi Selpa 
Published: June 2023

Bersepeda merupakan suatu kegiatan yang banyak di gemari oleh masyarakat, terutama masyarakat kota Padang, yang mana kota Padang merupakan kota yang memiliki dataran landai dan banyak terdapat pantai disisi jalan. Hal tersebut membuat kegiatan bersepeda di kawasan wisata pantai Padang banyak diminati oleh masyarakat. Namun kegiatan bersepeda di kawasan wisata pantai Padang masih bergabung dengan kendaraan bermotor lainnya sehingga menimbulkan kurang aman dan nyaman bagi pengendara sepeda. Pada hari Sabtu dan Minggu. Berdasarkan hasil survei geometrik dan survei lalu lintas yang dilakukan untuk rencana jalur khusus sepeda di Jalan Samudera pada kawasan wisata pantai Padang, hasilnya mendukung untuk direalisasikan, dengan volume lalu lintas tertinggi 1093,2 skr/jam di ruas kiri dan 1036 skr/jam di ruas kanan, dan di dapat nilai kapasitas jalan sebelum ada jalur sepeda 3082,147skr/jam dengan nilai Level Of Service B. Rencana jalur sepeda akan dibuat di badan jalan dengan lebar 1.5 m untuk satu lajur. Dengan nilai kapasitas setelah ada jalur sepeda 2739,686 skr/jam dan didapat nilai Level Of Service B. Kata Kunci: sepeda,kapasitas jalan
PERENCANAAN SALURAN IRIGASI SEKUNDER D.I KAUMAN KECAMATAN RAO SELATAN KABUPATEN PASAMAN
Authors: Harianto Harianto , Eka Priana Surya , Susanti Yusman Ana 
Published: June 2023

An Agrarian Country is an Indonesian country so it is reasonable if the main priority in the national agenda is centered on agriculture. In addition, the growth of population and industry is increasing. Therefore, it is necessary to improve the canals whose working function is decreasing. This Kauman Irrigation Area irrigates an area of 250 Ha of paddy fields. The source of water in the Kauman Irrigation District comes from the Batang river. Batang Lansat Kadap Irrigation Area is ± 45 km from Lubuk Sikaping city center. In Irrigation Network Planning, a design analysis must be done that includes rainfall analysis, discharge calculation, and channel dimensions. So that the irrigation system can be interpreted as an effort to provide maximum water supply. The main discharge of the planned channel is 3.24 m3/d, and the Max Debit is 2.44. The top dimension is 0.8, the bottom width is 0.6 and the height is 0.8. It can hold water when there is high rainfall. By improving the irrigation canals and providing enough water according to the needs, in planning, the dimensions of the canals are obtained through the process of rainfall by using the harpes method and the gumbel method. Keywords: food self-sufficiency, discharge, channel dimensions
IMPLEMENTASI BUILDING INFORMATION MODELING (BIM) PADA GEDUNG RUMAH QUR’AN UWAIS AL QARNI MENDALO JAMBI
Authors: Revi Ahmad , Ishak Ishak , Herista Febrimen 
Published: June 2023

Abstrak: Building information modelling (BIM) merupakan teknologi pada bidang AEC (Architecture, Engineerin and Construction) yang mensimulasikan seluruh informasi di dalam pembangunan ke dalam model 3 Dimensi. Penerapan BIM di Indonesia telah diterapkan oleh sejumlah sektor besar industri konstruksi, Bagaimana pemodelan dan hasil dari schedule Architectur, Structural dan Electrical dari Software OpenBuildings Designer Bab ini mencakup metode pengumpulan data dan menyajikan diagram alir untuk mempersiapkan tugas akhir,Data Sekunder,Teknik Pengumpulan Data, StudiDokumen, Metode penelitian ini menggunakan sistem building information modeling. Langkah-langkah analisis yang diambil untuk melaksanakan uraian di atas sesuai dengan metode yang ditetapkan openbuildings designer menghasilkan 3D dimensi model, beserta schedule dari arsitectural,strucural,dan electrical, Kesimpulan yang saya dapat dari penelitian yang berjudul Implementasi building information modeling pada Gedung Rumah Qur’an Uwais Al Qarni Mendalo Jambi adalah : 1. Openbuildings designer dapat di gunakan untuk memastikan bahwa keputusan desain yang di buat memiliki dampak yang baik di masa depan melalui perubahan dan stabilitas. 2. Openbuildings designer dapat menghasilkan schedule dari pemodelan Architectur, structural dan Electrical.Kata kunci : Building Information Modeling (BIM), OpenBuildings Designer, pemodelan Architectural, pemodelan Struktural, pemodelan Electrical
Kajian Awal Kekerabatan Bahasa Remun dan Iban Undop
Authors: Norahim Norazuna , Bandan Claudia Vica 
Published: June 2023

ABSTRAK

Bahasa Remun sering menarik minat pengkaji untuk meneliti aspek bahasanya kerana ciri linguistiknya yang agak berbeza daripada dialek-dialek Iban lain di Sarawak. Malah, ada pengkaji beranggapan varian Iban Remun ini berstatus “bahasa tersendiri” dan tidak menganggapnya sebagai dialek bahasa Iban. Justeru, kajian ini bertujuan untuk menentukan tahap hubungan kekerabatan di antara bahasa Remun dengan varian Iban lain di Sarawak khususnya bahasa Iban Undop. Selain kaedah leksikostatistik iaitu perbandingan kosa kata asas bagi menentukan peratusan kognat di antara kedua-dua varian ini, kajian ini juga membuat perbandingan kosa kata tambahan dan ciri fonologi. Hasil kajian mendapati tahap peratusan kata berkognat di antara varian-varian ini ialah 94.7%. Ini bermakna bahasa Iban Remun dan Iban Undop mempunyai hubungan dialektal. Data kajian turut menunjukkan banyak persamaan dari segi inventori fonem dan lingkungan kehadiran fonem dalam kata. Berdasarkan perbandingan kosa kata tambahan pula, didapati banyak perbezaan di antara varian-varian ini yang boleh menjejaskan kesalingfahaman di antara penutur mereka. Kajian ini juga menyarankan perlu dijalankan kajian susulan yang menyelusuri sejarah penyebaran dialek bahasa Iban di Sarawak serta perbandingan lebih terperinci bahasa Remun dengan varian Ibanik di Kalimantan.
Kata kunci: Borneo, Ibanik, kekerabatan bahasa, leksikostatistik, Remun
Advantages of FDM and gamma irradiation to manufacture personalized medical devices for airway obstructions
Authors: Aráoz Beatriz , Bellía-Munzón Gastón , Bousquet Juan I. , Hermida Élida B. 
Published: June 2023

In the early childhood population, congenital airway conditions like bronchomalacia (BM) can pose a life-threatening threat. A breakthrough technology called additive manufacturing, or 3D printing, makes it feasible to create a biomedical device that aids in the treatment of airway obstruction. This article describes how a polycaprolactone (PCL) splint for the upper airways can be created using the fusion deposition technique (FDM) and sterilized using gamma radiation. It is presented as a simple, accessible, and cost-reduced alternative that complements other techniques using more expensive and sophisticated printing methods. Thermomechanical and morphological analysis proved that FDM and sterilizing by gamma irradiation are both appropriate methods for producing splints to treat life-threatening airway blockages. Additionally, the 3D-printed splints’ effectiveness in treating a young patient with BM that was life-threatening was assessed by medical professionals. In this regard, the case report of a patient with 34 months of follow-up is presented. Splints manufactured by this affordable 3D printing method successfully surpass breathing arrest in life-threatening airway obstruction in pediatric patients. The success of this procedure represents a fundamental contribution to the treatment of the population in countries where access to expensive and complex technologies is not available.
Gene-repaired iPS cells as novel approach for patient with osteogenesis imperfecta
Authors: Fus-Kujawa Agnieszka , Mendrek Barbara , Bajdak-Rusinek Karolina , Diak Natalia , Strzelec Karolina , Gutmajster Ewa , Janelt Kamil , Kowalczuk Agnieszka , Trybus Anna , Rozwadowska Patrycja , Wojakowski Wojciech , Gawron Katarzyna , Sieroń Aleksander L. 
Published: June 2023

Introduction: The benefits of patient’s specific cell/gene therapy have been reported in relation to numerous genetic related disorders including osteogenesis imperfecta (OI). In osteogenesis imperfecta particularly also a drug therapy based on the administration of bisphosphonates partially helped to ease the symptoms.Methods: In this controlled trial, fibroblasts derived from patient diagnosed with OI type II have been successfully reprogrammed into induced Pluripotent Stem cells (iPSCs) using Yamanaka factors. Those cells were subjected to repair mutations found in the COL1A1 gene using homologous recombination (HR) approach facilitated with star polymer (STAR) as a carrier of the genetic material.Results: Delivery of the correct linear DNA fragment to the osteogenesis imperfecta patient’s cells resulted in the repair of the DNA mutation with an 84% success rate. IPSCs showed 87% viability after STAR treatment and 82% with its polyplex.Discussion: The use of novel polymer Poly[N,N-Dimethylaminoethyl Methacrylate-co-Hydroxyl-Bearing Oligo(Ethylene Glycol) Methacrylate] Arms (P(DMAEMA-co-OEGMA-OH) with star-like structure has been shown as an efficient tool for nucleic acids delivery into cells (Funded by National Science Centre, Contract No. UMO-2020/37/N/NZ2/01125).
Engineering the methylotrophic yeast Ogataea polymorpha for lactate production from methanol
Authors: Wefelmeier Katrin , Schmitz Simone , Haut Anna Maria , Otten Johannes , Jülich Tobias , Blank Lars Mathias 
Published: June 2023

Introduction: Lactate has gained increasing attention as a platform chemical, particularly for the production of the bioplastic poly-lactic acid (PLA). While current microbial lactate production processes primarily rely on the use of sugars as carbon sources, it is possible to envision a future where lactate can be produced from sustainable, non-food substrates. Methanol could be such a potential substrate, as it can be produced by (electro)chemical hydrogenation from CO2.Methods: In this study, the use of the methylotrophic yeast Ogataea polymorpha as a host organism for lactate production from methanol was explored. To enable lactate production in Ogataea polymorpha, four different lactate dehydrogenases were expressed under the control of the methanol-inducible MOX promoter. The L-lactate dehydrogenase of Lactobacillus helveticus performed well in the yeast, and the lactate production of this engineered strain could additionally be improved by conducting methanol fed-batch experiments in shake flasks. Further, the impact of different nitrogen sources and the resulting pH levels on production was examined more closely. In order to increase methanol assimilation of the lactate-producing strain, an adaptive laboratory evolution experiment was performed.Results and Discussion: The growth rate of the lactate-producing strain on methanol was increased by 55%, while at the same time lactate production was preserved. The highest lactate titer of 3.8 g/L in this study was obtained by cultivating this evolved strain in a methanol fed-batch experiment in shake flasks with urea as nitrogen source. This study provides a proof of principle that Ogataea polymorpha is a suitable host organism for the production of lactate using methanol as carbon source. In addition, it offers guidance for the engineering of methylotrophic organisms that produce platform chemicals from CO2-derived substrates. With reduced land use, this technology will promote the development of a sustainable industrial biotechnology in the future.
CCL2 promotes osteogenesis by facilitating macrophage migration during acute inflammation
Authors: Toya Masakazu , Zhang Ning , Tsubosaka Masanori , Kushioka Junichi , Gao Qi , Li Xueping , Chow Simon Kwoon-Ho , Goodman Stuart B. 
Published: June 2023

Novel minimally invasive strategies are needed to obtain robust bone healing in complex fractures and bone defects in the elderly population. Local cell therapy is one potential option for future treatment. Mesenchymal stromal cells (MSCs) are not only involved in osteogenesis but also help direct the recruitment of macrophages during bone regeneration via MSC-macrophage crosstalk. The C-C motif chemokine ligand 2 (CCL2) is an inflammatory chemokine that is associated with the migration of macrophages and MSCs during inflammation. This study investigated the use of CCL2 as a therapeutic target for local cell therapy. MSCs and macrophages were isolated from 10 to 12 week-old BALB/c male mice. Genetically modified CCL2 over-expressing MSCs were produced using murine CCL2-secreting pCDH-CMV-mCCL2-copGFP expressing lentivirus vector. Osteogenic differentiation assays were performed using MSCs with or without macrophages in co-culture. Cell migration assays were also performed. MSCs transfected with murine CCL2-secreting pCDH-CMV-mCCL2-copGFP expressing lentivirus vector showed higher levels of CCL2 secretion compared to unaltered MSCs (p &lt; 0.05). Genetic manipulation did not affect cell proliferation. CCL2 did not affect the osteogenic ability of MSCs alone. However, acute (1 day) but not sustained (7 days) stimulation with CCL2 increased the alizarin red-positive area when MSCs were co-cultured with macrophages (p &lt; 0.001). Both recombinant CCL2 (p &lt; 0.05) and CCL2 released from MSCs (p &lt; 0.05) facilitated macrophage migration. We demonstrated that acute CCL2 stimulation promoted subsequent osteogenesis in co-culture of MSCs and macrophages. Acute CCL2 stimulation potentially facilitates osteogenesis during the acute inflammatory phase of bone healing by directing local macrophage migration, fostering macrophage-MSC crosstalk, and subsequently, by activating or licensing of MSCs by macrophage pro-inflammatory cytokines. The combination of CCL2, MSCs, and macrophages could be a potential strategy for local cell therapy in compromised bone healing.
Infertility and cortisol: a systematic review
Authors: Karunyam Bheena Vyshali , Abdul Karim Abdul Kadir , Naina Mohamed Isa , Ugusman Azizah , Mohamed Wael M. Y. , Faizal Ahmad Mohd , Abu Muhammad Azrai , Kumar Jaya 
Published: June 2023

IntroductionStress and infertility form a complex relationship. In line with this, various stress-related biological markers have been investigated in infertility.MethodsThis systematic review was performed using PRISMA guidelines (i) to report whether cortisol is highly present in infertile patients compared to fertile control; (ii) to report whether there is any significant difference in the cortisol level in infertile subjects that conceive and those that didn’t at the end of assisted reproduction treatments. Original articles involving human (male and female) as subjects were extracted from four electronic databases, including the list of references from the published papers. Sixteen original full-length articles involving male (4), female (11), and both genders (1) were included.ResultsFindings from studies that compared the cortisol level between infertile and fertile subjects indicate that (i) Male: three studies reported elevated cortisol level in infertile patients and one found no significant difference; (ii) Female: four studies reported increased cortisol level in infertile subjects and three studies found no significant difference. Findings from studies that measured the cortisol level from infertile patients that conceived and those that didn’t indicate that (i) Male: one study reported no significant difference; (ii) Female: one study reported elevated cortisol in infertile patients that conceived, whereas two studies reported increased cortisol in infertile patients that was unable to conceive. Five studies found no significant difference between the groups.DiscussionIn the present review we only included the cortisol value that was measured prior to stimulation or IVF treatment or during natural or spontaneous cycles, despite this, there are still variations in the sampling period, assessment techniques and patients’ characteristics. Hence, at present, we are still unable to conclude that cortisol is significantly elevated in infertile patients. We warrant future studies to standardize the time of biological sample collection and other limitations that were addressed in the review to negate the unwanted influencing factors.