bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adverse events associated with anti-IL-17 agents for psoriasis and psoriatic arthritis: a systematic scoping review
Authors: Wang Jiao , Wang Chunxiao , Liu Liu , Hong Seokgyeong , Ru Yi , Sun Xiaoying , Chen Jiale , Zhang Miao , Lin Naixuan , Li Bin , Li Xin 
Published: January 2023

BackgroundAnti-interleukin (IL)-17 biological agents (BAs) have significant efficacy in the treatment of psoriasis and psoriatic arthritis; however, adverse events (AEs) are common, and their safety has not been systematically evaluated.ObjectivesThe purpose of this systematic review and meta-analysis was to summarize the number and corresponding rates of AEs caused by anti-IL-17 BAs in patients with psoriasis and psoriatic arthritis to improve clinical decision-making regarding their use.MethodsPubMed, Embase, Cochrane Library, and Web of Science databases were independently searched by three authors for articles on the treatment of psoriasis with anti-IL-17 BAs that were published before March 1, 2022, and included at least one AE. Dichotomous variables and 95% confidence intervals (CI) were analyzed using R software (version 4.1.3) and the Meta and Metafor software packages. Funnel plots and meta-regression were used to test for the risk of bias, I2 was used to assess the magnitude of heterogeneity, and subgroup analysis was used to reduce heterogeneity.ResultsA total of 57 studies involving 28,424 patients with psoriasis treated with anti-IL-17 BAs were included in the meta-analysis. Subgroup analysis showed that anti-IL-17A (73.48%) and anti-IL-17A/F (73.12%) BAs were more likely to cause AEs than anti-IL-17R BAs (65.66%). The incidence of AEs was as high as 72.70% with treatment durations longer than one year, and long-term use of medication had the potential to lead to mental disorders. Infection (33.16%), nasopharyngitis (13.74%), and injection site reactions (8.28%) were the most common AEs. Anti-IL-17 BAs were most likely to cause type α (33.52%) AEs. Type δ AEs (1.01%) were rarely observed.ConclusionsAnti-IL-17 BAs used for the treatment of psoriasis and psoriatic arthritis caused a series of AEs, but the symptoms were generally mild.
Metabolomics for biomarker discovery in schistosomiasis: A systematic scoping review
Authors: Midzi Herald , Vengesai Arthur , Muleya Victor , Kasambala Maritha , Mduluza-Jokonya Tariro Lavender , Chipako Isaac , Siamayuwa Clayton Edmore , Mutapi Francisca , Naicker Thajasvarie , Mduluza Takafira 
Published: January 2023

BackgroundMetabolomic based approaches are essential tools in the discovery of unique biomarkers for infectious diseases via high-throughput global assessment of metabolites and metabolite pathway dysregulation. This in-turn allows the development of diagnostic tools and provision of therapeutics. In this review, we aimed to give an overview of metabolite biomarkers and metabolic pathway alterations during Schistosoma haematobium and Schistosoma mansoni infections.MethodsWe conducted the review by systematically searching electronic databases and grey literature to identify relevant metabolomics studies on schistosomiasis. Arksey and O’Malley methodology for conducting systematic scoping reviews was applied. A narrative summary of results was conducted following the Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for scoping review guidelines.ResultsTwelve articles included in the review identified 127 metabolites, whose concentrations were considerably altered during S. mansoni and S. haematobium infections. The metabolites were assigned to metabolic pathways involved in energy (34.6%), gut microbial (11.0%), amino acid (25.2%), nucleic acids (6.3%), immune proteins (8.7%) hormones (2.4%) and structural proteins/lipids (11.8%). Energy related metabolic pathways were the most affected during schistosome infections with metabolites such as succinate, citrate, aconitate and fumarate of the tricarbocylic acid cycle being significantly altered in organ, serum and plasma samples. Amino acid metabolism was also impacted during schistosome infections as phenylacetylglycine, alanine, taurine, 2-oxoisocaproate and 2-oxoisovalerate emerged as potent biomarkers. Elevated structural proteins such as actin, collagen and keratin concentrations were identified as biomarkers of liver fibrosis, a common pathological feature in chronic schistosomiasis infections. Hippurate was a major metabolite biomarker in the gut microbial related pathway.ConclusionsThe analysis of the literature revealed that energy related metabolic pathways are considerably altered during S. mansoni and S. haematobium infections. Therefore, their metabolites may provide biomarkers for diagnosis and prognosis in addition to providing therapeutics for parasitic infections. This scoping review has identified a need to replicate more schistosomiasis metabolomic studies in humans to complement animal-model based studies.
A novel prognostic model related to oxidative stress for treatment prediction in lung adenocarcinoma
Authors: Peng Haijun , Li Xiaoqing , Luan Yanchao , Wang Changjing , Wang Wei 
Published: January 2023

BackgroundThe prognostic model based on oxidative stress for lung adenocarcinoma (LUAD) remains unclear.MethodsThe information of LUAD patients were acquired from TCGA dataset. We also collected two external datasets from GEO for verification. Oxidative stress-related genes (ORGs) were extracted from Genecards. We performed machine learning algorithms, including Univariate Cox regression, Random Survival Forest, and Least Absolute Shrinkage and Selection Operator (Lasso) analyses on the ORGs to build the OS-score and OS-signature. We drew the Kaplan-Meier and time-dependent receiver operating characteristic curve (ROC) to evaluate the efficacy of the OS-signature in predicting the prognosis of LUAD. We used GISTIC 2.0 and maftool algorithms to explore Genomic mutation of OS-signature. To analyze characteristic of tumor infiltrating immune cells, ESTIMATE, TIMER2.0, MCPcounter and ssGSEA algorithms were applied, thus evaluating the immunotherapeutic strategies. Chemotherapeutics sensitivity analysis was based on pRRophetic package. Finally, PCR assays was also used to detect the expression values of related genes in the OS-signature in cell lines.ResultsTen ORGs with prognostic value and the OS-signature containing three prognostic ORGs were identified. The significantly better prognosis of LUAD patients was observed in LUAD patients. The efficiency and accuracy of OS-signature in predicting prognosis for LUAD patients was confirmed by survival ROC curves and two external validation data sets. It was clearly observed that patients with high OS-scores had lower immunomodulators levels (with a few exceptions), stromal score, immune score, ESTIMATE score and infiltrating immune cell populations. On the contrary, patients with higher OS-scores were more likely to have higher tumor purity. PCR assays showed that, MRPL44 and CYCS were significantly higher expressed in LUAD cell lines, while CAT was significantly lower expressed.ConclusionThe novel oxidative stress-related model we identified could be used for prognosis and treatment prediction in lung adenocarcinoma.
The optimal regional irradiation volume for breast cancer patients: A comprehensive systematic review and network meta-analysis of published studies
Authors: Qi Wei-Xiang , Cao Lu , Xu Cheng , Cai Gang , Chen Jiayi 
Published: January 2023

BackgroundCurrently, the optimal adjuvant regional nodal irradiation (RNI) volume for breast cancer (BC) remained controversial. We aimed to define the optimal RNI treatment volume for BC by using a comprehensive network meta-analysis (NMA) of published studies.Materials and methodsPubMed, Embase, Medline, and Cochrane Central Register of Controlled Trials were searched from database inception to 30 May 2022. Studies assessing different adjuvant RNI volumes for BC were eligible for inclusion. The primary outcome was overall survival (OS), and secondary outcome was disease-free survival (DFS) and distant-metastasis-free survival (DMFS).ResultsA total of 29,640 BC patients from twenty studies were included. The pooled hazard ratio demonstrated that internal mammary node irradiation (IMNI) in BC patients significantly improved OS giving HR (hazard ratio) of 0.87 (95%CI: 0.83–0.91, p&lt;0.001), DFS with HR of 0.78 (95%CI: 0.68–0.90, p&lt;0.01), and DMFS with HR of 0.87 (95%CI: 0.79–0.97, p&lt;0.01) when compared to controls. Sub-group analysis indicated that RNI with IMNI significantly improved OS (HR 0.87, 95%CI: 0.81–0.93, p&lt;0.01), DFS (HR 0.65, 95%CI: 0.56–0.77, p&lt;0.01), and DMFS (HR 0.90, 95%CI: 0.82–0.98, p=0.02) when compared to RNI without IMNI. NMA showed that CW/WB (chest wall/whole breast) + RNI with IMNI significantly improved DFS (HR 0.93, 95%CI: 0.86–1.00) and DMFS (HR 0.90, 95%CI: 0.81–0.99), but not for OS (HR 0.93, 95%CI: 0.84–1.03) when compared to CW/WB alone. Based on the analysis of the treatment ranking, CW/WB+RNI with IMNI appeared as the best treatment approach for BC patients.ConclusionsOur pooled results demonstrated that RNI with IMNI yielded a significant survival advantage for BC patients. NMA showed that CW/WB+RNI with IMNI was the optimal radiation volume for BC patients.
Monoparametric high-resolution diffusion weighted MRI as a possible first step in an MRI-directed diagnostic pathway for men with suspicion of prostate cancer
Authors: Reijnen Jeroen Sebastiaan , Ryg Una , Marthinsen Jon B. , Schönhardt Irina , Seierstad Therese , Hole Knut H. 
Published: January 2023

PurposeTo explore if a high-resolution diffusion weighted MRI sequence (DWI-only) could be used as a first step in an MRI-directed diagnostic pathway.MethodsProspective single center study that between December 2017 and August 2018 included 129 consecutive patients with suspicion of prostate cancer into a PI-RADS-based MRI-directed diagnostic pathway. All patients had multiparametric MRI (mpMRI). Based on only the transversal high-resolution DWI images two consultant radiologists prospectively categorized the findings as positive, equivocal, or negative for clinically significant cancer. The radiologists then interpreted the mpMRI and assigned a PI-RADS score. A third independent reader retrospectively categorized the DWI-only exams without access to the mpMRI. The interpretations of DWI-only were compared to the PI-RADS classification from mpMRI and the histopathology from the biopsies. Non-biopsied patients were followed in a safety net monitoring for 56 months.ResultsBased on DWI-only, 29 (22.5%) of the exams were categorized as negative, 38 (29.5%) as equivocal and 62 (48.1%) as positive. Of the 56 patients with PI-RADS 4-5 at mpMRI, 55 were also categorized as positive at DWI-only. All patients diagnosed with clinically significant cancer were identified using DWI-only. 56 months of safety net monitoring did not reveal any clinically significant cancers among patients with exams categorized as negative or equivocal. There was high inter-reader agreement on positive findings, but less agreement on negative and equivocal findings.ConclusionsIn this concept study, the monoparametric DWI-only identified all patients with clinically significant cancer in a mpMRI-directed diagnostic pathway.
Preoperative prognostic prediction for stage I lung adenocarcinomas: Impact of the computed tomography features associated with the new histological grading system
Authors: Liang Min , Tang Wei , Tan Fengwei , Zeng Hui , Guo Changyuan , Feng Feiyue , Wu Ning 
Published: January 2023

ObjectivesThis study aimed to identify the computed tomography (CT) features associated with the new International Association for the Study of Lung Cancer (IASLC) three-tiered grading system to improve the preoperative prediction of disease-free survival of stage I lung adenocarcinoma patients.MethodsThe study included 379 patients. Ordinal logistic regression analysis was used to identify the independent predictors of IASLC grades. The first multivariate Cox regression model (Model 1) was based on the significant factors from the univariate analysis. The second multivariate model (Model 2) excluded the histologic grade and based only on preoperative factors.ResultsLarger consolidation tumor ratio (OR=2.15, P&lt;.001), whole tumor size (OR=1.74, P=.002), and higher CT value (OR=3.77, P=.001) were independent predictors of higher IASLC grade. Sixty patients experienced recurrences after 70.4 months of follow-up. Model 1 consisted of age (HR:1.05, P=.003), clinical T stage (HR:2.32, P&lt;.001), histologic grade (HR:4.31, P&lt;.001), and burrs sign (HR:5.96, P&lt;.001). Model 2 consisted of age (HR,1.04; P=.015), clinical T stage (HR:2.49, P&lt;.001), consolidation tumor ratio (HR:2.49, P=.016), whole tumor size (HR:2.81, P=.022), and the burrs sign (HR:4.55, P=.002). Model 1 had the best prognostic predictive performance, followed by Model 2, clinical T stage, and histologic grade.ConclusionCTR (cut-off values of &lt;25% and ≥75%) and whole tumor size (cut-off value of 17 mm) could stratify patients into different prognosis and be used as preoperative surrogates for the IASLC grading system. Integrating these CT features with clinical T staging can improve the preoperative prognostic prediction for stage I lung adenocarcinoma patients.
A CT-based radiomics approach to predict immediate response of radiofrequency ablation in colorectal cancer lung metastases
Authors: Huang Haozhe , Zheng Dezhong , Chen Hong , Chen Chao , Wang Ying , Xu Lichao , Wang Yaohui , He Xinhong , Yang Yuanyuan , Li Wentao 
Published: January 2023

ObjectivesTo objectively and accurately assess the immediate efficacy of radiofrequency ablation (RFA) on colorectal cancer (CRC) lung metastases, the novel multimodal data fusion model based on radiomics features and clinical variables was developed.MethodsThis case-control single-center retrospective study included 479 lung metastases treated with RFA in 198 CRC patients. Clinical and radiological data before and intraoperative computed tomography (CT) scans were retrieved. The relative radiomics features were extracted from pre- and immediate post-RFA CT scans by maximum relevance and minimum redundancy algorithm (MRMRA). The Gaussian mixture model (GMM) was used to divide the data of the training dataset and testing dataset. In the process of modeling in the training set, radiomics model, clinical model and fusion model were built based on a random forest classifier. Finally, verification was carried out on an independent test dataset. The receiver operating characteristic curves (ROC) were drawn based on the obtained predicted scores, and the corresponding area under ROC curve (AUC), accuracy, sensitivity, and specificity were calculated and compared.ResultsAmong the 479 pulmonary metastases, 379 had complete response (CR) ablation and 100 had incomplete response ablation. Three hundred eighty-six lesions were selected to construct a training dataset and 93 lesions to construct a testing dataset. The multivariate logistic regression analysis revealed cancer antigen 19-9 (CA19-9, p&lt;0.001) and the location of the metastases (p&lt; 0.05) as independent risk factors. Significant correlations were observed between complete ablation and 9 radiomics features. The best prediction performance was achieved with the proposed multimodal data fusion model integrating radiomic features and clinical variables with the highest accuracy (82.6%), AUC value (0.921), sensitivity (80.3%), and specificity (81.4%).ConclusionThis novel multimodal data fusion model was demonstrated efficient for immediate efficacy evaluation after RFA for CRC lung metastases, which could benefit necessary complementary treatment.
Resolution Revolution—Seeing the Molecules of Life With Electron Cryomicroscopy
Authors: Segev Noa , Henderson Richard 
Published: January 2023

This article is based on an interview between the two authors.Structural biology is a field that seeks to find the structures of all the components that make up living things—from molecules that exist in humans and other animals, through molecules present in tiny microorganisms, to the molecules that make up plants. To determine these structures, structural biologists use sophisticated imaging techniques that are becoming more and more accurate at “seeing”, or determining the structure of smaller and more diverse molecules. Electron cryomicroscopy is one very advanced and powerful imaging technique. In this technique, electrons are sent through frozen specimens to determine the structures of single molecules, at magnifications that are enough to see atoms. These images are taking us one step further toward understanding the structure and function of the basic building blocks of life. In this article, we will tell you about the developments that led to what is called “the resolution revolution” in electron cryomicroscopy, which Dr. Henderson was part of and that eventually allowed him to share the Nobel Prize in Chemistry in 2017.
FACILITATE: A real-world, multicenter, prospective study investigating the utility of a rapid, fully automated real-time PCR assay versus local reference methods for detecting epidermal growth factor receptor variants in NSCLC
Authors: Behnke Anke , Cayre Anne , De Maglio Giovanna , Giannini Giuseppe , Habran Lionel , Tarsitano Marina , Chetta Massimiliano , Cappellen David , Lespagnol Alexandra , Le Naoures Cecile , Massazza Gabriella , Destro Annarita , Bonzheim Irina , Rau Achim , Battmann Achim , Kah Bettina , Watkin Emmanuel , Hummel Michael 
Published: January 2023

Accurate testing for epidermal growth factor receptor (EGFR) variants is essential for informing treatment decisions in non-small cell lung cancer (NSCLC). Automated diagnostic workflows may allow more streamlined initiation of targeted treatments, where appropriate, while comprehensive variant analysis is ongoing. FACILITATE, a real-world, prospective, multicenter, European study, evaluated performance and analytical turnaround time of the Idylla™ EGFR Mutation Test compared with local reference methods. Sixteen sites obtained formalin-fixed paraffin-embedded biopsy samples with ≥ 10% neoplastic cells from patients with NSCLC. Consecutive 5 μm sections from patient samples were tested for clinically relevant NSCLC-associated EGFR variants using the Idylla™ EGFR Mutation Test and local reference methods; performance (concordance) and analytical turnaround time were compared. Between January 2019 and November 2020, 1,474 parallel analyses were conducted. Overall percentage agreement was 97.7% [n = 1,418; 95% confidence interval (CI): 96.8–98.3], positive agreement, 87.4% (n = 182; 95% CI: 81.8–91.4) and negative agreement, 99.2% (n = 1,236; 95% CI: 98.5–99.6). There were 38 (2.6%) discordant cases. Ninety percent of results were returned with an analytical turnaround time of within 1 week using the Idylla™ EGFR Mutation Test versus ∼22 days using reference methods. The Idylla™ EGFR Mutation Test performed well versus local methods and had shorter analytical turnaround time. The Idylla™ EGFR Mutation Test can thus support application of personalized medicine in NSCLC.
Intentional Measures to Achieve a Child's Mental Health
Authors: Mubark Allafi Mathayel , Ali S’aadh Amjad 
Published: January 2023

Objectives: The study aims to clarify the concept of mental health from an Islamic perspective, explaining the meaning of intentional measures, and the importance of the child’s mental health in accordance with the purposes of sharia, and clarify the treatments developed by the purposes of sharia in order to support the mental health of children.
Methods: The study is based on two approaches; the inductive approach: by extrapolating and following the legal purposes in the rulings related to the child and enhancing his/her mental health, and the analytical approach: analysis of the legal texts of the Qur’an and sunnah, in addition, the branches of jurisprudence.
Results: The necessary legitimate purposes have a direct role in supporting children’s mental health, that the three approaches to mental health: preventive, developmental, and curative, are consistent with the purposes of legitimacy in several places, and that the preventive approach meets the legal rulings based on preserving the necessities to preserve existence, while the therapeutic approach meets the legal rulings that work to preserve the necessities from the side of nothingness, and the Islamic approach achieves the fulfillment of the four health aspects: spiritual, psychological, social and biological.
Conclusions: The necessity of paying attention to the provisions of the child’s mental health, study and application, by adding relevant educational material to Islamic education courses in schools, and setting up mandatory educational courses for those who are about to marry, aiming to raise awareness of the child’s mental health from a legal perspective.
Yield improvement in fabrication of a molecular-gap atomic switch by eliminating potential leakage current paths
Authors: Ishijima Haruki , Hasegawa Tsuyoshi 
Published: January 2023

Abstract
A molecular-gap atomic switch is one of the emerging devices that works as a synaptic device. It shows good enough performance such as analog resistance change over five orders of magnitude. However, low yield in device fabrication due to short-circuit of as-fabricated devices has been a big issue. In this study, we Investigated the causes of the low yield and found several possible leakage current paths in unexpected routes. A new device structure and fabrication processes that eliminate the potential leakage paths were proposed. Operating characteristics were evaluated at each step in the improvement, and finally yield in the device fabrication was improved from 10% to 80%.
Analisa Pengukuran Kinerja Green Supply Chain pada Sektor Usaha Kecil
Authors: Septivani Nike 
Published: January 2023

Rantai pasok (supply chain) adalah suatu jaringan fasilitas dan saluran distribusi yang meliputi pengadaan dari bahan baku, produksi, perakitan dan pengiriman produk atau pelayanan kepada pelanggan. Seiring dengan berkembangnya industri, pemerintah gencar dalam menerapkan peraturan yang menyangkut tentang pemeliharaan lingkungan.
GSC (green supply chain) merupakan konsep rantai pasok yang mempertimbangkan lingkungan. Pengukuran kinerja dalam GSC menjadi hal yang penting untuk menilai pelaksanaan dan capaian dari suatu desain green. Melalui pengukuran kinerja GSC, suatu organisasi atau perusahaan dapat mengambil keputusan mengenai kesesuaian dan kelanjutan strategi yang digunakan, juga menjadi dasar perlu tidaknya dilakukan penggantian strategi. Tujuan dari penelitian ini antara lain untuk mengetahui penerapan GSC pada beberapa sektor usaha dan untuk memahami hal – hal apa saja yang ada di dalam komponen GSC sehingga sektor usaha tetap sustain. Penelitian dilakukan pada pertengahan tahun 2022 di sektor produksi tempe daerah Bogor. Teknik analisis untuk melakukan pengukuran kinerja green supply chain menggunakan metode deskriptif, analytical hierarchy process (AHP). Penyusunan laporan penelitian dilengkapi dengan metode kepustakaan dan melakukan wawancara dengan responden. Hasil dari penelitian ini antara lain: Pertama penerapan GSC dengan menentukan 4 perspektif yaitu green procurement, green manufacture, green distribution, reverse logistics beserta tujuan dari masing – masing perspektif dan hasil dari keempat perspektif tersebut konsisten dengan kinerja produksi dan Kedua, proses perbaikan yang harus dilakukan oleh sektor usaha yang diamati berdasarkan hasil pengukuran tidak diperlukan namun perlu dipertimbangkan apabila permintaan produksi dari konsumen lebih banyak dari sebelumnya.