bluuebunny/crossref_metadata_2025_split huggingface dataset:
In‐hospital mortality of heparin‐induced thrombocytopenia in end‐stage kidney disease. A retrospective national population‐based cohort study
Authors: Ghimire Calvin , Baral Nischit , Vinjam Tejaswi , Mathews Simi M. , Baral Nisha , Acharya Bandana , Savarapu Pramod K. , Bashyal Krishna , Kunadi Arvind , Mitchell Joshua D. 
Published: December 2022

AbstractAimHeparin induced thrombocytopenia (HIT) and end stage kidney disease (ESKD) are independent conditions associated with increased mortality and morbidity, however, whether ESKD is an independent risk factor for increased mortality in HIT admissions is not well studied. Therefore, we aimed to compare in‐hospital mortality in HIT admissions based on their ESKD status.MethodsThis is a retrospective cohort study of HIT hospitalizations aged 18 and older using the 2016–2019 national inpatient sample (NIS) database.ResultsFrom 2016 to 2019 we had 12 161 admissions for HIT among 28 484 087 total hospitalizations. The annual incidence rate for HIT admissions per 100 000 admissions were: 47, 46, 41.1, and 36.6, respectively (p < .001) in 2016, 2017, 2018, and 2019 respectively. Among HIT admissions, the mean age was 64.3 years, 46.8% were females, 68% were Whites and 16% were Blacks. Black patients have a significantly higher likelihood of in‐hospital mortality than White patients (aOR 1.25; 95% CI: 1.06, 1.48; p = .007). Patients who did not have any insurance or self‐pay had higher mortality compared to Medicare (aOR 1.64; 95% CI: 1.13, 2.38; p = .009). ESKD status was not associated with higher or lower in‐hospital mortality among HIT admissions (aOR 1.002; 95% CI: 0.84, 1.19; p = .981) after adjusting for age, sex, race, and insurance status.ConclusionThere are no higher or lower odds of in‐hospital mortality in the ESKD subgroup in HIT admissions in adults. Decreasing incidence of HIT hospitalizations was seen over the years from 2016 to 2019.
Machine learning models for Neisseria gonorrhoeae antimicrobial susceptibility tests
Authors: Martin Skylar L. , Mortimer Tatum D. , Grad Yonatan H. 
Published: December 2022

AbstractNeisseria gonorrhoeae is an urgent public health threat due to the emergence of antibiotic resistance. As most isolates in the United States are susceptible to at least one antibiotic, rapid molecular antimicrobial susceptibility tests (ASTs) would offer the opportunity to tailor antibiotic therapy, thereby expanding treatment options. With genome sequence and antibiotic resistance phenotype data for nearly 20,000 clinical N. gonorrhoeae isolates now available, there is an opportunity to use statistical methods to develop sequence‐based diagnostics that predict antibiotic susceptibility from genotype. N. gonorrhoeae, therefore, provides a useful example illustrating how to apply machine learning models to aid in the design of sequence‐based ASTs. We present an overview of this framework, which begins with establishing the assay technology, the performance criteria, the population in which the diagnostic will be used, and the clinical goals, and extends to the choices that must be made to arrive at a set of features with the desired properties for predicting susceptibility phenotype from genotype. While we focus on the example of N. gonorrhoeae, the framework generalizes to other organisms for which large‐scale genotype and antibiotic resistance data can be combined to aid in diagnostics development.
The Correlation between Various Shoulder Anatomical Indices on X‐Ray and Subacromial Impingement and Morphology of Rotator Cuff Tears
Authors: Yang Jinsong , Xiang Ming , Li Yiping , Zhang Qing , Dai Fei 
Published: December 2022

ObjectivesRotator cuff injury caused by subacromial impingement presents different morphologies. This study aims to investigate the correlation between various shoulder anatomical indexes on X‐ray with subacromial impingement and morphology of rotator cuff tears to facilitate surgical management.MethodThis retrospective study was carried out between January 2020 and May 2022. Patients who were diagnosed as sub‐acromial impingement associated with rotator cuff tears (without tendon retraction) and received arthroscopic surgery were enrolled in this study. The radiographic indexes of acromial slope (AS), acromial tilt (AT), lateral acromial angle (LAA), acromial Index (AI), and sub‐acromial distance (SAD) were measured on preoperative true AP view and outlet view. The location of rotator cuff tear (anterior, middle, posterior, medial, and lateral) and morphology of tear (horizontal, longitudinal, L‐shaped, and irregular shaped) were evaluated by arthroscopy. Groups were set up due to different tear location and tear morphologies, by comparing the various radiographic indices between each group (one‐way analysis of variance and t‐test), the correlation between radiographic indices and tear characteristics was investigated.ResultsWe analyzed 92 shoulders from 92 patients with a mean age of 57.23 ± 8.45 years. The AS in anterior tear group (29.32 ± 6.91°) was significantly larger than that in middle tear group (18.41 ± 6.13°) (p = 0.000) and posterior tear group (24.01 ± 7.69°) (p = 0.041). The AS in posterior tear group (24.01 ± 7.69°) was significantly larger than that in middle tear group (18.41 ± 6.13°) (p = 0.029). The LAA in middle tear group (67.41 ± 6.54°) was significantly smaller than that in posterior group (72.74 ± 8.78°) (p = 0.046). The AS in longitudinal tear group (26.86 ± 8.41°) was significantly larger than that in horizontal tear group (22.05 ± 9.47°) (p = 0.035) and L‐shaped group (21.56 ± 6.62°) (p = 0.032). The LAA in horizontal group (70.60 ± 6.50°) was significantly larger than that in L‐shaped group (66.39 ± 7.31°) (p = 0.033). The AI in L‐shaped tear group (0.832 ± 0.074) was significantly larger than that in horizontal tear group (0.780 ± 0.084) (p = 0.019) and irregular tear group (0.781 ± 0.068) (p = 0.047).ConclusionAcromion with a larger AS and a smaller LAA tend to cause anterior or posterior rotator cuff tears rather than middle tears in sub‐acromial impingement. Meanwhile acromion with a larger AS tends to cause a longitudinal tear, a larger LAA tends to cause horizontal tears and a larger AI tends to cause L‐shaped tears.
A New Technique of Achilles Tendon Rupture Repaired by Double Transverse Mini‐incision to Avoid Sural Nerve Injury: A Consecutive Retrospective Study
Authors: Xu Lihu , Jin Jiaxin , Liu Zhongcheng , Wu Meng , Peng Bo , Jiang Jin , Liu Guangyao , He Jinwen , White Sylvia , Xia Yayi 
Published: December 2022

ObjectivePercutaneous suture is a classic technique used in Achilles tendon repair. However, the complication rates surrounding the sural nerve remain relatively high. Modified percutaneous repair technology can effectively avoid these complications; however, the surgical procedure is complicated. Hence, the present study was conducted to describe a redesigned repair technique for the Achilles tendon able to avoid sural nerve injury and reduce the complexity of the procedure.MethodsData of patients with acute primary Achilles tendon rupture at our hospital from January 2019 to May 2020 were included. Subjects with expectations for surgical scarring underwent a minimally invasive‐combined percutaneous puncture technique. The surgical time, requirement for conversion to other technologies, and length of postoperative hospitalization were investigated to assess efficacy. The American Orthopedic Foot & Ankle Society (AOFAS) score and the Arner–Lindholm scale (A‐L scale) were used to assess postoperative clinical outcomes (> 24 months). During the 2‐year follow‐up, MRI was performed to observe the healing of the Achilles tendon. In addition, subjective satisfaction with surgical scar healing was recorded.ResultsTwenty consecutive subjects with an average follow‐up of 28.3 ± 4.5 months (range, 24–41) met the inclusion criteria. None of the 20 enrolled patients required a converted surgical approach. The mean surgical time was 26.9 ± 6.47 min (range, 20–44). None of the patients experienced dysesthesia or anesthesia around the sural nerve. No signs of postoperative infections were observed. MRI data showed that the wounds of the Achilles tendon healed completely in all the subjects. The AOFAS score increased from 55.6 ± 11.07 (range, 28–71) preoperatively to 97.8 ± 3.34 (range, 87–100) at the last follow‐up. The A‐L scale showed that 90% of the subjects (n = 18) presented as excellent and 10% of the subjects (n = 2) presented as good, with an excellent/good rate of 100%. Moreover, subjects' satisfaction for surgical scars was 9.1 ± 0.78 (upper limit, 10).ConclusionsThe results indicate that this technique can achieve good postoperative function, a small surgical incision, and high scar satisfaction. In addition, this technique should be widely used in suturing Achilles tendon ruptures.
Rare improperly treated traumatic vertical atlantoaxial dislocation: A case report and literature review
Authors: Zou Qiang , Zhou Zhongjie , Yang Xi , Xiu Peng , Song Yueming , Li Yongning , Li Haibo 
Published: December 2022

BackgroundBecause of the severity and fatal outcome of traumatic vertical atlantoaxial dislocation (AAD), most patients may die in the early post‐traumatic period. The post‐injury management of patients with vertical AAD has been rarely reported. Improper treatment may lead to disastrous outcome and further aggravate the neurologic symptoms.Case PresentationThis report describes the perioperative management and outcome of a rare improperly treated patient with traumatic vertical AAD. The severe pulmonary infection of this patient prevented further surgery for vertical AAD. After placement of a halo vest, combined with effective antibiotic drug treatment, the patient's pulmonary infection was brought under control. The patient underwent atlantoaxial fusion using C1 lateral mass screws and C2 pedicle screws with the assistance of the halo vest. A computed tomography scan at 1 year follow‐up indicated that the bone graft was fused and the patient was able to walk independently.ConclusionSkull traction is contraindicated in patients with traumatic vertical AAD. Application of a halo vest can be used for temporary fixation of the cervical spine and atlantoaxial fixation should be performed to maintain the stability of atlantoaxial articulation.
Policy advocacy of nongovernmental organizations in China: A quasi‐replication of Zhan and Tang (2013, 2016)
Authors: Guo Shihong 
Published: December 2022

AbstractThis study widely replicates the original studies by Zhan and Tang to verify the impact of political opportunities and the resources of organizations on policy advocacy, which uses a much larger sample of nongovernmental organizations (NGOs) who engage with social work. The main findings of the present study are similar to those of the original studies. First, the study finds that the higher the level of government support, the more likely NGOs is to engage in policy advocacy. Second, the NGOs with stronger political connections are more active in policy advocacy. Third, the income of an organization also has a positive effect on policy advocacy. However, the number of full‐time staff, location, and the level of registration of an organization does not have a significant effect on policy advocacy. The study increases the understanding of policy advocacy and the relations between the state and society in China.
“Put a Little Love in Your Heart”: Acceptance of Paternalistic and Ally Political Discourses Both Predict Pro‐Roma Solidarity Intentions Through Moral Inclusion
Authors: Kende Anna , Sam Nariman Hadi , Nyúl Boglárka , Badea Constantina , Lášticová Barbara , Mahfud Yara , Gruev‐Vintila Andreea , Minescu Anca , O'Connor Ashley , Boza Mihaela , Poslon Xenia Daniela , Popper Miroslav , Hadarics Márton 
Published: December 2022

The way politicians talk about minorities institutes the normative context of intergroup relations. We investigated how endorsement of different political discourses predicts donation and collective action intentions by majority members toward the Roma in five European countries. The survey was conducted online using samples demographically similar to the populations of Hungary, Slovakia, Romania, France, and Ireland (N = 5,054). First, results showed that accepting paternalistic discourse versus discourse promoting allyship were not distinguishable; both promoted higher moral inclusion which in turn predicted higher prosocial intentions. Second, donations (i.e., immediate relief) and collective action (i.e., social change action) were driven by identical factors. Third, acceptance of openly hostile political discourse neither predicted moral exclusion, nor lower prosocial intentions. In summary, our research provides important evidence that when it comes to Roma—non‐Roma relations, the previously established distinction between solidarity intentions that aim to solidify status relations versus bring about social change is completely blurred, presumably because of the social context in which any positive message communicates moral inclusion challenging the hostile status quo.
Canonical conformal variables based method for stability of Stokes waves
Authors: Dyachenko S. A. , Semenova A. 
Published: December 2022

AbstractWe study the stability of Stokes waves in an ideal fluid of infinite depth. The perturbations that are either coperiodic with a Stokes wave (superharmonics) or integer multiples of its period (subharmonics) are considered. The eigenvalue problem is formulated using the conformal canonical Hamiltonian variables and admits numerical solution in a matrix‐free manner. We find that the operator matrix of the eigenvalue problem can be factored into a product of two operators: a self‐adjoint operator and an operator inverted analytically. Moreover, the self‐adjoint operator matrix is efficiently inverted by a Krylov‐space‐based method and enjoys spectral accuracy. Application of the operator matrix associated with the eigenvalue problem requires only flops, where N is the number of Fourier modes needed to resolve a Stokes wave. Additionally, due to the matrix‐free approach, storage for the matrix of coefficients is no longer required. The new method is based on the shift‐invert technique, and its application is illustrated in the classic examples of the Benjamin–Feir and the superharmonic instabilities. Simulations confirm numerical results of preceding works and recent theoretical work for the Benjamin–Feir instability (for small amplitude waves), and new results for large amplitude waves are shown.
Older home care clients' experiences of digitalisation: A qualitative study of experiences of the use of robot for medicines management
Authors: Turjamaa Riitta , Vaismoradi Mojtaba , Kangasniemi Mari 
Published: December 2022

AbstractBackgroundHome‐living older people with multiple medications are a key target group for medication robots. However, our understanding of how robots for medicines management work in older people's daily lives is limited.AimThe aim of this study was to describe older home care clients' experiences of the implementation and use of a robot for medicines management at home.DesignA qualitative interview study.MethodsData were collected during spring and autumn 2021 using semi‐structured individual interviews with older home care clients (n = 38). The data were analysed using inductive content analysis.ResultsThe older home care clients had positive experiences with the use of technology for the medication process, but they also faced challenges in their daily life activities. Implementation and use of the robot required open‐mindedness, satisfaction with the implementation, and the opportunity to practice the use of the robot with a nurse. However, the current design and size of the robot for medicines management in home care still need development, given that our research participants did not feel included in the robot development process.ConclusionThe use of digital solutions will increase older people's home care. Therefore, there is a need to deepen our understanding of the implementation and use of digital solutions to prevent digital challenges and to provide a more comprehensive picture of this phenomenon. In addition, research focusing on whether the use of the robot affects medication administration incidents and medication adherence should be conducted to improve the safety of medicines management.
Unraveling the genetics underlying micronutrient signatures of diversity panel present in brown rice through genome–ionome linkages
Authors: Pasion Erstelle A. , Misra Gopal , Kohli Ajay , Sreenivasulu Nese 
Published: December 2022

SUMMARYRice (Oryza sativa) is an important staple crop to address the Hidden Hunger problem not only in Asia but also in Africa where rice is fast becoming an important source of calories. The brown rice (whole grain with bran) is known to be more nutritious due to elevated mineral composition. The genetics underlying brown rice ionome (sum total of such mineral composition) remains largely unexplored. Hence, we conducted a comprehensive study to dissect the genetic architecture of the brown rice ionome. We used genome‐wide association studies, gene set analysis, and targeted association analysis for 12 micronutrients in the brown rice grains. A diverse panel of 300 resequencedindicaaccessions, with more than 1.02 million single nucleotide polymorphisms, was used. We identified 109 candidate genes with 5–20% phenotypic variation explained for the 12 micronutrients and identified epistatic interactions with multiple micronutrients. Pooling all candidate genes per micronutrient exhibited phenotypic variation explained values ranging from 11% to almost 40%. The key donor lines with larger concentrations for most of the micronutrients possessed superior alleles, which were absent in the breeding lines. Through gene regulatory networks we identified enriched functional pathways for central regulators that were detected as key candidate genes through genome‐wide association studies. This study provided important insights on the ionome variations in rice, on the genetic basis of the genome–ionome relationships and on the molecular mechanisms underlying micronutrient signatures.
Inactivation of SARS‐CoV‐2 infectivity in platelet concentrates or plasma following treatment with ultraviolet C light or with methylene blue combined with visible light
Authors: Hobson‐Peters Jody , Amarilla Alberto A. , Rustanti Lina , Marks Denese C. , Roulis Eileen , Khromykh Alexander A. , Modhiran Naphak , Watterson Daniel , Reichenberg Stefan , Tolksdorf Frank , Sumian Chryslain , Seltsam Axel , Gravemann Ute , Faddy Helen M. 
Published: December 2022

AbstractBackgroundSevere acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is unlikely to be a major transfusion‐transmitted pathogen; however, convalescent plasma is a treatment option used in some regions. The risk of transfusion‐transmitted infections can be minimized by implementing Pathogen Inactivation (PI), such as THERAFLEX MB‐plasma and THERAFLEX UV‐Platelets systems. Here we examined the capability of these PI systems to inactivate SARS‐CoV‐2.Study Design and MethodsSARS‐CoV‐2 spiked plasma units were treated using the THERAFLEX MB‐Plasma system in the presence of methylene blue (~0.8 μmol/L; visible light doses: 20, 40, 60, and 120 [standard] J/cm2). SARS‐CoV‐2 spiked platelet concentrates (PCs) were treated using the THERAFLEX UV‐platelets system (UVC doses: 0.05, 0.10, 0.15, and 0.20 [standard] J/cm2). Samples were taken prior to the first and after each illumination dose, and viral infectivity was assessed using an immunoplaque assay.ResultsTreatment of spiked plasma with the THERAFLEX MB‐Plasma system resulted in an average ≥5.03 log10 reduction in SARS‐CoV‐2 infectivity at one third (40 J/cm2) of the standard visible light dose. For the platelet concentrates (PCs), treatment with the THERAFLEX UV‐Platelets system resulted in an average ≥5.18 log10 reduction in SARS‐CoV‐2 infectivity at the standard UVC dose (0.2 J/cm2).ConclusionsSARS‐CoV‐2 infectivity was reduced in plasma and platelets following treatment with the THERAFLEX MB‐Plasma and THERAFLEX UV‐Platelets systems, to the limit of detection, respectively. These PI technologies could therefore be an effective option to reduce the risk of transfusion‐transmitted emerging pathogens.
The impact ofCOVID‐19 on international tourism flows to Italy: Evidence from mobile phone data
Authors: Della Corte Valerio , Doria Claudio , Oddo Giacomo 
Published: December 2022

AbstractThis paper analyses the response to the COVID‐19 pandemic of inbound tourism to Italy looking at variation across countries and provinces. To this end, it uses weekly data on the number of foreign visitors in Italy from January 2019 until February 2021, as provided by a primary mobile telephony operator. We document a very robust negative relation at the province level between the local epidemic situation and the inflow of foreign travellers. Moreover, provinces with a historically higher share in art‐tourism, and those that used to be ‘hotel intensive’ were hit the most during the pandemic, while provinces with a more prevalent orientation to business tourism proved to be more resilient. Entry restrictions with varying degrees of strictness played a key role in explaining cross‐country patterns. After controlling for these restrictions, we observed that the number of travellers that could arrive by private means of transportation decreased proportionally less. Overall, this evidence emphasises that contagion risk considerations played a significant role in shaping international tourism patterns during the pandemic.
On simple and interlaced property of the zeros of two entire functions
Authors: Liu Tao , Wei Guangsheng 
Published: December 2022

AbstractThis paper is concerned with two pairs , of entire functions of ‐type. We give conditions under which the zeros of and are real and interlaced for each . This result is used to deal with the inverse problems for the special transmission eigenvalue problem: with
We prove that, if its characteristic function has only nonreal zeros, then for each , there exists a unique real‐valued function such that the corresponding characteristic function of is .
A note on forward iteration of inner functions
Authors: Ferreira Gustavo R. 
Published: December 2022

AbstractA well‐known problem in holomorphic dynamics is to obtain Denjoy–Wolff‐type results for compositions of self‐maps of the unit disc. Here, we tackle the particular case of inner functions: if are inner functions fixing the origin, we show that a limit function of is either constant or an inner function. For the special case of Blaschke products, we prove a similar result and show, furthermore, that imposing certain conditions on the speed of convergence guarantees convergence of the boundary extensions. We give a counterexample showing that, without these extra conditions, the boundary extensions may diverge at all points of .
Various subgroups of Aut(Cn)${\rm{Aut}}({\mathbb{C}}^{n})$
Authors: Lin Zhangli , Zhou Xiangyu 
Published: December 2022

AbstractIn this paper, using ideas of Andersén and Lempert on the group of holomorphic automorphisms (), we prove that the subgroups in and () generated by different types of ‘shears’ are all distinct, which answer affirmatively to two conjectures posed by Forstnerič.