bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pre-analytical long-term stability of neopterin and neurofilament light in stored cerebrospinal fluid samples
Authors: Rosadas Carolina , Taylor Graham P. 
Published: January 2023

Abstract

Objectives
The aim of this study was to evaluate the impact of long-term sample storage on the concentrations of neopterin and neurofilament light (Nfl) in cerebrospinal fluid (CSF) samples. These are useful markers of neuroinflammation and neuronal damage and have been applied as biomarkers for several neurological diseases. However, different pre-analytical variables have potential to influence results.

Methods
Twenty-one CSF samples donated by patients with HTLV-1-associated myelopathy (HAM) and stored for up to 11 years at −80 °C were retested after three-years for neopterin (n=10) and Nfl (n=11) by ELISA.

Results
There was a strong correlation between the paired results (r>0.98, p<0.0001). Neopterin concentrations (nmol/L) ranged from 12.4 to 64 initially and from 11.5 to 64.4 when retested, with means (SD) of 30 (18.4) 1st test and 33 (19.1) 2nd test. Nfl concentrations (pg/mL) ranged from 79.9 to 3,733 initially and from 86.3 to 3,332, when retested with means (SD) of 1,138 (1,272) 1st test and 1,009 (1,114) at re-test.

Conclusions
Storing CSF samples at −80 °C appears not to impact the quantification of neopterin and Nfl allowing confidence in the reporting of archived samples.
C-reactive protein interacts with amphotericin B liposomes and its potential clinical consequences
Authors: Delanghe Joris R. , Himpe Jonas , Boelens Jerina , Benoit Dominique , Gadeyne Bram , Speeckaert Marijn M. , Verbeke Frederick 
Published: January 2023

Abstract

Objectives
Amphotericin B (AmB) is the gold standard for treating invasive fungal infections. New liposomal-containing AmB formulations have been developed to improve efficacy and tolerability. Serum/plasma C-reactive protein (CRP) values are widely used for monitoring infections and inflammation. CRP shows a high affinity to phosphocholine and it aggregates structures bearing this ligand, e.g. phosphocholine-containing liposomes. Therefore, we studied the interaction between CRP and phosphocholine-containing liposomal AmB preparations in vivo and in vitro.

Methods
CRP was prepared by affinity chromatography. Liposomal AmB (L-AmB, AmBisome®) was spiked (final concentrations of L-AmB: 150 mg/L) to CRP-containing serum (final CRP concentration: 300 mg/L). Following the addition of L-AmB, complex formation was monitored turbidimetrically. The size of CRP-L-AmB complexes was assessed using gel filtration. CRP was monitored in patients receiving either L-Amb or AmB lipid complex (ABLC).

Results
Following addition of L-AmB to CRP-containing plasma, turbidimetry showed an increase in absorbance. These results were confirmed by gel permeation chromatography. Similarly, in vivo effects were observed following intravenous administration of AmBisome®: a decline in CRP values was observed. In patients receiving L-Amb, decline of CRP concentration was faster than in patients receiving ABLC.

Conclusions

In vitro experiments are suggestive of a complexation between CRP and liposomes in plasma. Interpretation of CRP values following administration of AmBisome® might be impaired due to this complexation. In vivo formation of complexes between liposomes and CRP might contribute, or even lead, to intravascular microembolisation. Similar effects have been described following the administration of Intralipid® and other phosphocholine-containing liposomes.
Export Cutoff Productivity, Uncertainty and Duration of Waiting for Exporting
Authors: Duan Lianjie 
Published: January 2023

Abstract
Using China’s transaction-level trade data and firm-level production data during 2000–2006, this study first estimates the duration of Chinese industrial enterprises’ waiting for exporting. The results show that the average duration of waiting for exporting is 4.7 years and the median is 5 years. Besides, the hazard rate of export entry has the prominent positive duration dependence. Then, this study uses Cox proportional hazard model to analyse the impact of export cutoff productivity on the duration of waiting for exporting. The result indicates that the rise in the productivity threshold will significantly prolong the duration of waiting for exporting, and this conclusion is supported by a variety of robustness tests. In addition, the estimation result of hazard ratio shows that every 1% increase in productivity threshold will lead to a 0.1261% decrease in hazard rate of enterprises’ export entry. Moreover, the heterogeneity test indicates that the effect of export cutoff productivity on duration of enterprises’ waiting for exporting has the significant ownership and industry heterogeneity, but does not have the destination heterogeneity. Further, this study finds that China’s accession to the World Trade Organisation helps to weaken the threshold effect of export cutoff productivity on the duration of Chinese enterprises’ waiting for exporting, while the rise in the uncertainty will aggravate this effect. This study indicates that it should be the focus of government to actively promote the establishment of bilateral and multilateral free trade zones, to create a stable business environment for enterprises and to reduce the market uncertainty.
Fabrication of magnesium oxide nanoparticles using Eucalyptus tereticornis seed extract and their characterisation
Authors: Bhatt Khushboo , Agrawal Sonalika , Jain Vikas Kumar , Khan Fahmida 
Published: January 2023

Abstract
The green approach is a simple and efficient method for generating metal oxide nanoparticles. Magnesium oxide nanoparticles gained prominence due to their unique biodegradation, microbe growth inhibition, and non-toxicity properties. The seed extract of Eucalyptus tereticornis was used to make magnesium oxide nanoparticles in this research. Using X-ray diffraction data, the average crystallite size of nanoparticles is estimated to be about 10 nm. Face-centered cubic structured magnesium oxide nanoparticles have a spherical surface morphology, as seen in transmission electron microscopy and scanning electron microscopy images. Fourier transform infra-red spectra are used to identify functional groups involved in the stabilization and reduction of precursor salt. Magnesium oxide nanoparticles are employed for a variety of applications including temperature dehydrating agents, high-grade ceramic materials, optoelectronic fields, and bio-medical studies such as antibacterial and antimicrobial.
Energy production in one-qubit quantum Agrawal machines
Authors: Fernández Julio J. 
Published: January 2023

AbstractWe obtain the power and Ω-function of one-qubit Agrawal quantum heat engines solving the Lindbland equation and using the tools of Finite Time Thermodynamics. We prove that these two thermodynamic functions have their maximum values for efficiencies different to zero and the Carnot efficiency. Finally, analyzing the high temperature limit of AQHEs we discover the range of temperatures for which the quantum behaviour is valid.
Controlling surface waves with temporal discontinuities of metasurfaces
Authors: Wang Xuchen , Mirmoosa Mohammad S. , Tretyakov Sergei A. 
Published: January 2023

Abstract
Static reactive metasurfaces allow excitation and propagation of surface waves. In this paper, we theoretically elucidate how surface-wave propagation along a reactive boundary is affected by temporal discontinuities of effective parameters characterizing the boundary. First, we show that by switching the value of the surface reactance, the velocity of surface waves is fully controlled, and the power of reflected and transmitted surface waves can be amplified. Second, we indicate that when a boundary supporting waves with transverse-electric polarization is switched to the one allowing only transverse-magnetic polarization, the propagating surface wave is “frozen” and converted to a static magnetic-field distribution. Moreover, efficiently, these fields can be “melted”, restoring propagating surface waves when the boundary is switched back to the initial state. Finally, we demonstrate that temporal jumps of the boundary reactance couple free-space propagating waves to the surface wave, in an analogy to a spatial prism. All these intriguing phenomena enabled by temporal discontinuities of effective properties of reactive metasurfaces open up interesting possibilities for the generation and control of surface waves.
Increase in Mortality Rates of African-American Women Following Mandatory Arrest Laws: A Study in Unintended Effects
Authors: Ozel Sinan 
Published: January 2023

Abstract
From the late 1970s into the 1990s, 20 states in the USA passed’ mandatory arrest laws’, designed to curb domestic violence, by requiring the responding officer to arrest the offender. I show that these laws led to an increase in the mortality rates of African-American women. The increase takes place approximately four years after the law was passed and loses its statistical significance as time passes. I infer from these results that mandatory arrest laws had unintended consequences for the victims whose partners were arrested, but that these unintended consequences impacted the victims only in the few years following the law. I conclude that increased awareness of the law and offender deterrence eventually mitigates these unintended consequences. I propose a potential explanation for the increase in mortality rates, and make a policy recommendation that offenders and victims be informed about the law change if such a change is to be made.
The Effects of Acute Resistance Exercise on Memory, Processing Speed, and Mood State After a Cognitive Challenge
Authors: Venezia Andrew C. , Barney Patrick , Spagnoli Daniela , Greco-Hiranaka Cannon , Piepmeier Aaron T. , Smith J. Carson , Weiss Lauren R. 
Published: January 2023

Abstract
Venezia, AC, Barney, P, Spagnoli, D, Greco-Hiranaka, C, Piepmeier, AT, Smith, JC, and Weiss, LR. The effects of acute resistance exercise on memory, processing speed, and mood state after a cognitive challenge. J Strength Cond Res 37(9): 1738–1745, 2023—Acute moderate-to-vigorous-intensity aerobic exercise has been shown to improve learning and memory, but the effectiveness of acute high-intensity resistance exercise for improving memory is not fully understood. Like acute aerobic exercise, acute resistance exercise increases arousal and circulating catecholamines, mechanisms suggested to mediate the memory-enhancing effects of acute exercise. Furthermore, although acute exercise has been shown to benefit mood state, it is unknown if high-intensity resistance exercise positively influences mood state after a cognitive challenge. In this within-subjects design, subjects (18- to 25-year-old men) completed an approximately 40-minute session of resistance exercise or seated rest. Immediately after, the Automated Neuropsychological Assessment Metrics (ANAM) Code Substitution (CS)-Learning, CS-Immediate Recognition, and CS-Delayed Recognition tasks were completed, followed by the ANAM Mood Scale. There were no significant effects of exercise on recognition memory; however, CS-Learning (attention and processing speed) was better after resistance exercise (p = 0.03). After the cognitive challenge, restlessness (p < 0.001), vigor (p = 0.03), and depression (p = 0.047) scores were higher after resistance exercise compared with rest; however, after false discovery rate correction, only restlessness remained significantly different between sessions (q = 0.002), whereas vigor (q = 0.09) and depression (q = 0.09) did not. These results suggest that an acute bout of resistance exercise improves attention and processing speed, although it does not improve recognition memory and has mixed effects on mood state in college-aged men.
TORC1 phosphorylates and inhibits the ribosome preservation factor Stm1 to activate dormant ribosomes
Authors: Shetty Sunil , Hofstetter Jon , Battaglioni Stefania , Ritz Danilo , Hall Michael N 
Published: January 2023

AbstractTarget of rapamycin complex 1 (TORC1) promotes biogenesis and inhibits the degradation of ribosomes in response to nutrient availability. To ensure a basal supply of ribosomes, cells are known to preserve a small pool of dormant ribosomes under nutrient‐limited conditions. However, the regulation of these dormant ribosomes is poorly characterized. Here, we show that upon inhibition of yeast TORC1 by rapamycin or nitrogen starvation, the ribosome preservation factor Stm1 mediates the formation of nontranslating, dormant 80S ribosomes. Furthermore, Stm1‐bound 80S ribosomes are protected from proteasomal degradation. Upon nutrient replenishment, TORC1 directly phosphorylates and inhibits Stm1 to reactivate translation. Finally, we find that SERBP1, a mammalian ortholog of Stm1, is likewise required for the formation of dormant 80S ribosomes upon mTORC1 inhibition in mammalian cells. These data suggest that TORC1 regulates ribosomal dormancy in an evolutionarily conserved manner by directly targeting a ribosome preservation factor.
Lack of the human choline transporter‐like protein SLC44A2 causes hearing impairment and a rare red blood phenotype
Authors: Koehl Bérengère , Vrignaud Cédric , Mikdar Mahmoud , Nair Thankam S , Yang Lucy , Landry Seyve , Laiguillon Guy , Giroux‐Lathuile Claudine , Anselme‐Martin Sophie , El Kenz Hanane , Hermine Olivier , Mohandas Narla , Cartron Jean Pierre , Colin Yves , Detante Olivier , Marlu Raphaël , Le Van Kim Caroline , Carey Thomas E , Azouzi Slim , Peyrard Thierry 
Published: January 2023

AbstractBlood phenotypes are defined by the presence or absence of specific blood group antigens at the red blood cell (RBC) surface, due to genetic polymorphisms among individuals. The recent development of genomic and proteomic approaches enabled the characterization of several enigmatic antigens. The choline transporter‐like protein CTL2 encoded by the SLC44A2 gene plays an important role in platelet aggregation and neutrophil activation. By investigating alloantibodies to a high‐prevalence antigen of unknown specificity, found in patients with a rare blood type, we showed that SLC44A2 is also expressed in RBCs and carries a new blood group system. Furthermore, we identified three siblings homozygous for a large deletion in SLC44A2, resulting in complete SLC44A2 deficiency. Interestingly, the first‐ever reported SLC44A2‐deficient individuals suffer from progressive hearing impairment, recurrent arterial aneurysms, and epilepsy. Furthermore, SLC44A2null individuals showed no significant platelet aggregation changes and do not suffer from any apparent hematological disorders. Overall, our findings confirm the function of SLC44A2 in hearing preservation and provide new insights into the possible role of this protein in maintaining cerebrovascular homeostasis.
Eksistensi Syaikh Ahmad Surkati sebagai Tokoh Pembaharuan Islam di Indonesia 1914-1943
Authors: Rusli Rusli , Desmaniar Desmaniar , Nofenchi Sindy Yeindra 
Published: January 2023

Permasalahan pokok dalam penelitian ini adalah Pembaharuan Islam yang dibawa Syaikh Ahmad Surkati di Indonesia 1914-1943. Penelitian ini bertujuan untuk mengetahui: (1) Syaikh Ahmad Surkati tidak diterima oleh Jamiat Khair, (2) Syaikh Ahmad Surkati diterima dengan baik oleh Kolonial Belanda, (3) Pemikiran Pembaharuan Syaikh Ahmad Surkati dan Pandangan Tokoh Pembaharuan Islam di Indonesia. Hasil penelitian ini menunjukkan bahwa Pertama, Syaikh Ahmad Surkati tidak diterima oleh Jamiat Khair karena memiliki pemikiran tentang Fatwa Solo yang isinya memperbolehkan wanita keturunan nabi menikah dengan laki-laki bukan keturunan nabi karena menurutnya tidak ada beda antara orang Arab dengan pribumi. Kedua, Syaikh Ahmad Surkati diterima dengan baik oleh Belanda karena pada ketika itu diterapkan masa politik etis (Politik Balas Budi) pada saat itu keturunan Arab memiliki pangkat yang tinggi sehingga bisa mengajar di Indonesia dan Syaikh Ahmad Surkati juga bisa berbahasa Melayu dan memiliki sertifikat tertinggi guru agama di Istanbul. Ketiga: pemikiran pembaharuan Syaikh Ahmad Surkati dan pandangan tokoh pembaharuan Islam di Indonesia. Pemikiranya yaitu pernikahan wanita syarifah (wanita keturunan nabi) dengan pria keturunan non alawiyah (bukan keturunan nabi), ijtihad dan taqlid kemudian menziarahi makam dan bertawasul kepada nabi serta pandangan tokoh pembaharuan Islam tentang ia adalah datang dari Buya Hamka yang mengatakan dialah yang teguh pendirian dan memiliki ilmu yang luas.
Pengembangan Kompetensi Guru Sejarah dalam Memanfaatkan Media Pembelajaran Berbasis Teknologi Informasi dan Komunikasi (TIK) pada Satuan Pendidikan Tingkat SMA
Authors: Dwiminjawati Neneng , Sermal Sermal 
Published: January 2023

Penelitian ini menggunakan metode library research atau studi pustaka dengan langkah-langkah: Pertama jenis penelitian library research, penulis menggunakan teknik pengumpulan data dengan mengadakan studi penelaahan terhadap buku-buku, literatur-literatur, catatan-catatan dan laporan-laporan yang ada hubunganya dengan masalah yang akan dipecahkan. Kedua langkah riset kepustakaan, dengan cara menyiapkan perlengkapan dan menyusun bibliografi kerja. Ketiga, pedekatan hermeunitika yakni penafsiran sumber dan filsafat yakini gagasan dan ide sesuai kebenaran data yang ada. Keempat teknik pengumpulan data, yakni dengan dokumentasi seperti buku, jurnal dan lainnya. Kelima analisis dan interprestasi data yakni mengambil kesimpulan dan memberikan makna terhadap data. Hasil penelitian ini menunjukkan bahwa, pengembangan kompetensi guru sejarah terhadap kompetensi pedagogik dan kompetensi professional dalam pemanfaatan media TIK dapat dengan pemanfaatan pengunaan media berbasis Tekonologi Informasi Dan Komunikasi (TIK), seperti terdiri dari teknologi komputer, teknologi multimedia, teknologi jaringan komputer. Serta media teknologi yang terdiri dari, Electronic Mail / E-mail adres, Mailling List, Audio Kaset, vidio, Microsoft Powerpoint, E-Learning, Computer Based Intruction (CBI) serta Ditance Learning. Sedangkan analisis keterpaduan kompetensi guru sejarah dengan program yang ada oleh pemerintah, pemerintah mengeluarkan program untuk mendukung kompetensi guru sejarah melalui program Uji Kompetensi Guru (UKG), program peningkatan kualifikasi guru, program penyetaraan dan sertfikasi, program pelatihan terintegrasi berbasis kompetensi, program supervise pendidikan, Program Musyawarah Guru Mata Pelajaran (MGMP), symposium guru dan sebagainya.
Efektivitas Penggunaan Metode Peer Tutoring dalam Mengatasi Kesulitan Belajar Sejarah pada Kelas XI di MA Hasanah Islamic Boarding School
Authors: Fajri Suryadi , Lisa Ekrisna , Sermal Sermal 
Published: January 2023

Penelitian ini bertujuan untuk mengetahui sejauh mana keefektifan penggunaan Metode Peer Tutoring dalam mengatasi kesulitan belajar Sejarah Pada Kelas XI di MA PK Hasanah Islamic Boarding school. Jenis penelitian yang dilaksanakan adalah Penelitian Kualitatif Deskriptif. Subyek penelitian ini adalah Kepala Madrasah, Guru Pengampu Mata pelajaran Sejarah, dan siswa Kelas XI MA PK Hasanah. Teknik pengumpulan data pada penelitian ini yaitu dengan wawancara, observasi dan studi dokementasi. Hasil dari penelitian setelah di analisa menunjukkan bahwa penggunaan Metode Peer Tutoring dinilai efektif untuk mengatasi masalah kesulitan belajar Sejarah siswa Kelas XI MA PK Hasanah karena telah memenuhi beberapa syarat belajar yang efektif diantaranya adalah bisa mengantarkan siswa mencapai tujuan mata pelajaran serta bisa membuat siswa lebih atraktif pada saat pembelajaran Sejarah berlangsung di Kelas XI MA PK Hasanah Islamic Boarding School.
Will Demographic Changes Affect Monetary Policy with Interest Rate Shocks in Indonesia?
Authors: Qori'ah Ciplis Gema , Sugiyanto Catur , Hardi Amirullah Setya 
Published: January 2023

Changes in the demographic structure and its impact on the economy are becoming interesting issues in almost all countries in the world, including Indonesia. Until 2030, the working age group dominates almost 60 percent of the total population in Indonesia. This phenomenon is a valuable asset which should be used optimally. Moderate adjustment of interest rate policy is an effort applied by Bank Indonesia to maximize the access to credit and public savings. Therefore, this study aims to determine the effect of demographic aspects and the real sector on the effectiveness of monetary policy in the presence of interest rate shocks. This study employed time series data with a time period of 1987Q1 – 2020Q4 in Indonesia. The analysis was performed by using time varying parameter-vector autoregressive (TVP-VAR) and fully modified-ordinary least square (FM-OLS). The results revealed that the population and the elderly population aspects had significant positive effects on the monetary policy, while the variable of productive age and the number of dependence aspects has significant negative effects. The relationship between the real sector and the monetary policy has a different relationship, such as a positive relationship between the savings and technology variables and the domestic credit variable which has a significant negative relationship with the monetary policy.
APPLICATION OF GAMIFICATION IN ETHNIC EXCELLENCE-BASED CHARACTER EDUCATION PROGRAMS
Authors: Lasambouw Carolina M , Nuryati Neneng , Sutjiredjeki Ediana , Farid N. Moh. , Sumeru Sumeru , Yuliawati Sri N , Hodijah Ade 
Published: January 2023

This paper describes how the game is a tool to support the strengthening of character education for its users. In implementing the Independent Learning Education, Merdeka Campus, Bandung State Polytechnic, collaborated with the industry to apply gamification to the concept of character education and the nation's cultural values. Some of the objectives of this gamification activity are: (a) Getting the ethnic group’s information; (b) Providing users inspiration to develop themselves; (c) Growing a better direction mindset. The game developed is a web-based application (online gamification), so as many students/students and lecturers as possible can use the game to support strengthening character education and the nation's cultural values. The manual version of the video game content (prototype) is available, namely the 2021 research output containing Pancasila character content based on ethnic excellence. The elements of educational content in online gamification contain the results of identifying the prominent characters of 10 ethnic groups in Indonesia with the largest population (Dayak, Madura, Jawa, Sunda, Baduy, Batak, Banjar, Minahasa, Betawi, Minang). This study used three approaches which are Qualitative-Explorative, Qualitative-Descriptive, and Evaluation. The method used to know how gamification was implemented in character education and the nation's cultural values. It is hoped that gamification can integrate into the learning process for compulsory national subjects. Thus, students can become users and a market for the gamification industry.