bluuebunny/crossref_metadata_2025_split huggingface dataset:
Noninvasive blood–brain barrier integrity mapping in patients with high‐grade glioma and metastasis by multi–echo time–encoded arterial spin labeling
Authors: Hoffmann Gabriel , Preibisch Christine , Günther Matthias , Mahroo Amnah , van Osch Matthias J. P. , Václavů Lena , Metz Marie‐Christin , Jung Kirsten , Zimmer Claus , Wiestler Benedikt , Kaczmarz Stephan 
Published: January 2025

AbstractPurposeIn brain tumors, disruption of the blood–brain barrier (BBB) indicates malignancy. Clinical assessment is qualitative; quantitative evaluation is feasible using the K2 leakage parameter from dynamic susceptibility contrast MRI. However, contrast agent–based techniques are limited in patients with renal dysfunction and insensitive to subtle impairments. Assessing water transport times across the BBB (Tex) by multi‐echo arterial spin labeling promises to detect BBB impairments noninvasively and potentially more sensitively.We hypothesized that reduced Tex indicates impaired BBB. Furthermore, we assumed higher sensitivity for Tex than dynamic susceptibility contrast–based K2, because arterial spin labeling uses water as a freely diffusible tracer.MethodsWe acquired 3T MRI data from 28 patients with intraparenchymal brain tumors (World Health Organization Grade 3 & 4 gliomas [n = 17] or metastases [n = 11]) and 17 age‐matched healthy controls. The protocol included multi‐echo and single‐echo Hadamard‐encoded arterial spin labeling, dynamic susceptibility contrast, and conventional clinical imaging. Tex was calculated using a T2‐dependent multi‐compartment model.Areas of contrast‐enhancing tissue, edema, and normal‐appearing tissue were automatically segmented, and parameter values were compared across volumes of interest and between patients and healthy controls.ResultsTex was significantly reduced (−20.3%) in contrast‐enhancing tissue compared with normal‐appearing gray matter and correlated well with |K2| (r = −0.347). Compared with healthy controls, Tex was significantly lower in tumor patients' normal‐appearing gray matter (Tex,tumor = 0.141 ± 0.032 s vs. Tex,HC = 0.172 ± 0.036 s) and normal‐appearing white matter (Tex,tumor = 0.116 ± 0.015 vs. Tex,HC = 0.127 ± 0.017 s), whereas |K2| did not differ significantly. Receiver operating characteristic analysis showed a larger area under the curve for Tex (0.784) than K2 (0.604).ConclusionTex is sensitive to pathophysiologically impaired BBB. It agrees with contrast agent–based K2 in contrast‐enhancing tissue and indicates sensitivity to subtle leakage.
Discussing Weight in Real World GP Consultations: A Video Recording Analysis Study
Authors: Norman Kimberley , Giri Neha , Gunatillaka Nilakshi , West Kellie , Ramachandran Divya , Sturgiss Elizabeth 
Published: January 2025

ABSTRACTObjectiveGPs have a complex role in obesity management due to patients' individualized experience of living with obesity, coupled with the challenge to deliver healthcare messages in non‐stigmatizing ways. This study aimed to explore who initiates the topic of weight and how weight was discussed in real‐world GP‐patient consultations.MethodA multi‐disciplinary team, including obesity lived experience experts, undertook a secondary data analysis of 43 Australian video recorded consultations and patient surveys from The Digital Library using descriptive content analysis.Results17/43 consultations included the topic of weight in the discussion. 15 were initiated by the GP and 2 by the patient. 14/17 used a structured approach. All GPs asked for consent to discuss weight or gave patients space to decline the discussion. No overt stigmatizing language was identified. A post‐consultation survey found 15/17 patients (2 unanswered) felt listened to and respected during consultations.ConclusionThis study identified the intricate ways GPs approach weight discussions in consultations. GPs navigated weight discussions in ways that made patients feel respected and listened to and related weight to health concerns relevant to each patient.Practice ImplicationsThe findings in this study can serve as a foundation for establishing education and training resources for GPs and can be utilized as a way of continuing professional development. Any future communication technique resources for GPs should be co‐designed with obesity lived experience experts to ensure appropriateness and avoid potential stigma and harm.
Drilling mechanism of temperature‐sensitive non‐directional UHMWPE fiber composites
Authors: Fu Chaolong , Huang Yuyuan , Jiang Qingrui , Ma Yujie , Hu Shanshan , Zhang Genge 
Published: January 2025

AbstractUltra‐high molecular weight polyethylene (UHMWPE) fiber composites have been widely used in aerospace, construction, and other fields; however, chip winding and poor drilling quality was greatly influenced by the drilling temperature because of the fiber and substrate's inherent temperature sensitivity. Drilling Experiments of nondirectional UHMWPE short fiber composites was conducted with four different drill bits to investigate the drilling mechanism affecting by drill bits types and drilling temperature. A unique chip‐winding mechanism and its relationship with drilling temperature and drilling force was proposed. The results showed that the spindle speed was the key factor affecting the drilling force, drilling temperature, chips morphology and chip‐winding. The polycrystalline diamond (PCD) drill bit was better than the other drill bits in terms of chip removal capacity, hole wall surface quality, and drilling temperature. When the spindle speed was set at 135 m/min, the drilling temperature and quality were the most stable. The melting temperature of the fibers in the drilling process was about 20°C (24%) higher than its real melting point. In addition, when the drilling temperature was lower than the melting point of UHMWPE fiber (90–140°C), the fracture modes of fibers was mainly tensile and extrusion fracture; while fibers melted on hole inner wall to increase the roughness of the hole wall at temperatures above the melting point (140 ~ 175°C).Highlights
The winding mechanism of UHMWPE fiber composites was analyzed for the first time.
The spindle speed and drilling temperature are both determinants of the hole quality.
PCD drill bit achieved better hole quality when drilling UHMWPE fiber composites.
The fiber fracture mechanism under the influence of drilling temperature was analyzed.
Rapid Determination of Crocin‐I in Gardenia Fruits (Gardenia jasminoides Ellis) by Combining Spectral and Image Data Through Hyperspectral Imaging
Authors: Xu Xin‐Yue , Jie Xiao‐Lu , Wu Jia‐Hui , Xia Dan‐Ping , Xu Zhou‐Duan , Luo Zi‐Rui , Fei Fei , Zhou Wei‐Kang , Tao Yi , Kawagishi Hirokazu , Wu Jing , Wang Ping , Feng Pei‐Shi 
Published: January 2025

ABSTRACTIntroductionCrocin‐I, a water‐soluble carotenoid pigment, is an important coloring constituent in gardenia fruit. It has wide application in various industries such as food, medicine, chemical industry, and so on. So the content of crocin‐I plays a key role in evaluating the quality of gardenia.ObjectiveWe assessed crocin‐I content in gardenia with a rapid, nondestructive, and convenient method.MethodThe data of gardenia samples were scanned under a portable visible–near‐infrared (Vis–NIR) hyperspectral imaging (HSI) in the spectral range of 400–1000 nm. Afterward, the spectral data along with image‐related information, encompassing color and texture, were extracted from the HSI. Based on a single information and its fusion at different fusion levels (low‐level, traditional mid‐level fusion, and an improved mid‐level fusion), partial least squares regression (PLSR) prediction models were established and compared.ResultThe results demonstrated the superiority of data fusion, which ingeniously combined spectra and image data. Compared with individual information sources, the traditional mid‐level fusion model showed a robust predictive ability. The correlation coefficient of the prediction set (Rp), the root mean square error of prediction (RMSEP), and the ratios of performance to deviation (RPDP) of the model were 0.901, 0.962, and 2.262, respectively.ConclusionThis study highlights the effectiveness of the data fusion method, showcasing its capacity to significantly enhance the prediction accuracy of crocin‐I content in gardenia through the integration of hyperspectral mapping data. The findings of this research are anticipated to serve as a valuable reference for predicting the active ingredients of other Chinese herbal medicines.
Effect and Mechanism of an ACT‐Based Psychological Resilience Intervention Targeting Students Failing in Postgraduate Entrance Examinations in China: A Randomized Controlled Trial
Authors: Han Jing , Zhao Ziyi , Ren Zhihong 
Published: January 2025

ABSTRACTThe postgraduate entrance examination frenzy is a widespread and intense phenomenon in China. As the number of students who failed the examination surged, the ensuing mental health problems became prominent. This study aimed to evaluate the effectiveness of an online ACT‐based group resilience course, which incorporated the six core components of ACT and integrated elements of Chinese culture, in alleviating psychological distress among students who failed the examination. It also explored the mechanism by which the intervention affected changes in psychological distress. A total of 61 participants were randomly assigned to the intervention group (n = 31) and the control group (n = 30). They attended an 8‐day group course, with 2‐h sessions each day. The study outcomes were psychological distress, resilience, psychological flexibility (PF), and psychological inflexibility (PI). These outcomes were measured at baseline, post‐intervention, and 1‐month follow‐up. Linear mixed models (LMMs) showed significant group × time interactions for all outcome variables, except for stress, which showed a marginally significant interaction. Post hoc analyses revealed significant improvements in depression, resilience, and PF at both post‐intervention and at the 1‐month follow‐up. Additionally, significant reductions in anxiety and a marginally significant reduction in stress were observed at the 1‐month follow‐up. However, no significant reduction was found in PI. The multiple mediation model showed that the intervention improved psychological distress by increasing resilience and PF. These findings suggest that online resilience group intervention is generally effective in enhancing resilience and alleviating psychological distress and is acceptable to students who have failed the postgraduate entrance examination, as evidenced by high participant engagement and satisfaction.
Response of Amblyseius swirskii to deltamethrin
Authors: Benavent‐Albarracín Luis , Pérez‐Hedo Meritxell , Alonso‐Valiente Miquel , Catalán José , Urbaneja Alberto , González‐Cabrera Joel 
Published: January 2025

AbstractBACKGROUNDThe rising demand for environmentally friendly pest control highlights the importance of understanding the interaction between natural enemies and pesticides. Amblyseius swirskii, a predatory mite extensively used in biocontrol, plays a crucial role in managing pest populations in agricultural systems. Integrating this mite with selective pesticide use within integrated pest management (IPM) would significantly advance pest control and may reduce pesticide residues in the environment and agricultural produce.This study characterized the susceptibility of two Amblyseius swirskii colonies to deltamethrin, a widely used pesticide, to assess their potential integration into IPM strategies.RESULTSBoth colonies exhibited significant tolerance to deltamethrin at concentrations higher than the maximum recommended field rate. Our analysis identified mutations in the target site in both populations. The commercial population also showed a contribution of cytochromes P450 to the resistant phenotype. Despite these results, semi‐field trials revealed a significant reduction in mite counts post‐treatment with deltamethrin; various experiments were conducted to understand this discrepancy.CONCLUSIONThis study underscores the need for comprehensive evaluations of pesticide impacts on biological control agents to optimize IPM strategies. Understanding pesticide resistance and field performance dynamics is crucial for developing sustainable pest management practices that ensure environmental resilience and agricultural productivity. © 2025 The Author(s). Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
Spatiotemporal‐Behavior‐Based Neighborhood Interaction Opportunities and Subjective Neighborhood Perception in Mixed‐Housing Neighborhoods: A Case Study of Fuzhou, China
Authors: Tang Yifan , Zhang Xue 
Published: January 2025

ABSTRACTResearch on residential spatial segregation has been increasingly emphasized by urban planners and geographers. This study delves into the long‐debated social effects of mixed‐housing neighborhood policies, focusing on the crucial aspect of social integration among residents. Our empirical research, conducted in Fuzhou, China, involves a comprehensive analysis of residents' spatiotemporal behavior across different housing types. By examining 48‐h activity diaries and socioeconomic questionnaires, and assessing neighborhood spatiotemporal opportunities for socializing, we aim to shed light on the relationship between objective and subjective perspectives of interaction. The influencing factors were revealed based on multiple linear regression modeling. Our findings reveal that residents of affordable housing exhibit higher levels of social interaction opportunities, whereas those in commercial housing demonstrate greater willingness to interact with neighbors. Moreover, residents' spatiotemporal behavior has a greater impact on the results of objective measures of neighborhood interaction opportunities, especially indicators related to shopping activities. In terms of policy recommendations, the study suggests organizing more community activities, improving the built environment, and enriching various consumption spaces around neighborhoods to foster interactions among residents of different housing types.
A Multiple‐Model‐Informed Drug‐Development Approach for Optimal Regimen Selection of an Oncolytic Virus in Combination With Pembrolizumab
Authors: Yamada Akihiro , Choules Mary P. , Brightman Frances A. , Takeshita Shigeru , Nakao Shinsuke , Amino Nobuaki , Nakayama Takeshi , Takeuchi Masato , Komatsu Kanji , Ortega Fernando , Mistry Hitesh , Orrell David , Chassagnole Christophe , Bonate Peter L. 
Published: January 2025

ABSTRACTThe antitumor efficacy of an intratumoral injection of a genetically engineered oncolytic vaccinia virus carrying human IL‐7 and murine IL‐12 genes (hIL‐7/mIL‐12‐VV) was demonstrated in CT26.WT‐bearing mice. In the CT26.WT‐bearing mouse model, the efficacy of the combination of hIL‐7/mIL‐12‐VV plus the anti‐programmed cell death protein (PD)‐1 antibody was determined to be correlated with the timing of administration: greater efficacy was observed when hIL‐7/mIL‐12‐VV was administered before the anti‐PD‐1 agent instead of simultaneous administration. To identify an optimal dosing regimen for first‐in‐human clinical trials, a multiple model‐informed drug‐development (MIDD) approach was used through development of a quantitative systems pharmacology (QSP) model and an agent‐based model (ABM). All models were built and verified using available literature and preclinical study data. Multiple dosing scenarios were explored using virtual populations by altering the interval between hIL‐7/hIL‐12‐VV and pembrolizumab administration. In contrast with observations from preclinical studies, both the QSP and the ABM models demonstrated no antagonistic effect on the dose‐dependent antitumor efficacy of hIL‐7/hIL‐12‐VV by pembrolizumab in simulations of clinical therapy. Based on the MIDD strategy, it was recommended that the highest dose of hIL‐7/hIL‐12‐VV and pembrolizumab should be administered on the same day, but with pembrolizumab administration following hIL‐7/hIL‐12‐VV administration. Multiple different modeling approaches uniquely supported and informed the first‐in‐human clinical trial design by guiding the optimal dose and regimen selection.
Responding to the October 7th Attack: Analyzing Israeli Public Organizations' Crisis Communication and Citizen Engagement on Social Media
Authors: Mabillard Vincent , Zumofen Raphaël , Yavetz Gal , Bronstein Jenny 
Published: January 2025

ABSTRACTFollowing the Hamas attack of October 7, 2023, in Israel, communication instantly became an essential tool for public officials needing to inform and protect the population. This paper analyzes how Facebook was used by Israeli public organizations after the attack, and the impact of social‐media content on citizen engagement in the case of a terrorist attack. Such attacks often involve unpredictable, rapidly evolving situations that require immediate and accurate information dissemination to counteract misinformation and panic. Our analysis helps better understand audiences' reactions based on the contents shared. By identifying engaging messages, public administrations can refine their strategies to efficiently share critical information on social media. Based on comparisons of post content categories, our analysis reveals that while news‐related posts generate more engagement, the opposite applies to reassurance and empowerment. The highest levels of engagement, in absolute terms, are observed when public authorities publish posts about citizen collaboration.
Wide‐Bandgap Cu(In, Ga)S2 Solar Cell: Mitigation of Composition Segregation in High Ga Films for Better Efficiency
Authors: Adeleye Damilola , Sood Mohit , Valluvar Oli Arivazhagan , Törndahl Tobias , Hultqvist Adam , Vanderhaegen Aline , Lanzoni Evandro Martin , Hu Yucheng , Kusch Gunnar , Melchiorre Michele , Redinger Alex , Oliver Rachel A. , Siebentritt Susanne 
Published: January 2025

AbstractCu(In, Ga)S2 demonstrates potential as a top cell material for tandem solar cells. However, achieving high efficiencies has been impeded by open‐circuit voltage (VOC) deficits arising from In‐rich and Ga‐rich composition segregation in the absorber layer. This study presents a significant improvement in the optoelectronic quality of Cu(In, Ga)S2 films through the mitigation of composition segregation in three‐stage co‐evaporated films. By elevating the substrate temperature during the first stage, the intermixing of In and Ga is promoted, leading to reduced Cu(In, Ga)S2 composition segregation. Furthermore, the optimization of Cu‐excess during the second stage minimizes non‐radiative voltage loss. These combined strategies yield quasi‐Fermi level splitting exceeding 1 eV and a record VOC of 981 mV in Cu(In, Ga)S2 devices. Consequently, a champion device achieves an in‐house power conversion efficiency (PCE) of 16.1% (active area) and a certified PCE of 14.8%, highlighting the potential of Cu(In, Ga)S2 as a stable and efficient top‐cell device for tandem photovoltaics.
Facile Design of Highly Stretchable and Conductive Crumpled Graphene/NiS2 Films for Multifunctional Applications
Authors: Weng Kangwei , Jing Qiji , Gao Jindong , Wang Weiguo , Zhang Chen , Wang Jun , Cheng Huanyu , Zhang Cheng 
Published: January 2025

AbstractThe cost‐effective and scalable synthesis and patterning of soft nanomaterial composites with improved electrical conductivity and mechanical stretchability remains challenging in wearable devices. This work reports a scalable, low‐cost fabrication approach to directly create and pattern crumpled porous graphene/NiS2 nanocomposites with high mechanical stretchability and electrical conductivity through laser irradiation combined with electrodeposition and a pre‐strain strategy. With modulated mechanical stretchability and electrical conductivity, the crumpled graphene/NiS2 nanocomposite can be readily patterned into target geometries for application in a standalone stretchable sensing platform. By leveraging the electrical energy harvested from the kinetic motion from wearable triboelectric nanogenerator (TENG) and stored in micro‐supercapacitor arrays (MSCAs) to drive biophysical sensors, the system is demonstrated to monitor human motions, body temperature, and toxic gas in the exposed environment. The material selections, design strategies, and fabrication approaches from this study provide functional nanomaterial composites with tunable properties for future high‐performance bio‐integrated electronics.
Colloidal Synthesis of Na2Fe2(SO4)3 Nanocrystals as the Cathode Toward High‐Rate Capability and High‐Energy Density Sodium‐ion Batteries
Authors: Li Shuhui , Wang Weihuang , Jia Yixin , Xu Huidong , Liu Rui , Wang Zheng , Xie Zicheng , Zhang Lantian , He Rong , Wang Liangbing 
Published: January 2025

AbstractAlluaudite‐type Na2+2xFe2‐x(SO4)3 (NFS) with high theoretical energy density is regarded as the promising cathode of sodium‐ion batteries (SIBs), while practical rate and cyclic performances are still hindered by intrinsic poor conductivity. Here, a facile method is developed, collaborating high‐boiling organic solvents assisted colloidal synthesis (HOS‐CS) with sintering for tailoring Na2Fe2(SO4)3 nanocrystals decorated by conductive carbon network toward high‐rate‐capability cathode of SIBs. Impressively, the as‐prepared Na2Fe2(SO4)3@MC provides 60.6 and 46.9 mAh g−1 of reversible capacities even at ultrahigh rates of 20 and 30 C, respectively, ranking the superior state among the current NFS‐based cathode. More importantly, Na2Fe2(SO4)3@MC achieves 73% of capacity retention at 20 C after 500 cycles, highlighting its potential for application as a fast chargeable cathode. As a bonus, the full‐cell configuration constructed with Na2Fe2(SO4)3@MC cathode and commercial hard carbon (HC) anode delivers 45.6 mAh g−1 at 10 C and 68.3 mAh g−1 of initial capacity with ≈79.4% of retention after 100 cycles at 2 C. Also, Na2Fe2(SO4)3@MC||HC full cell supplies as high as 140 Wh kg−1 of practical energy density. This work offers a novel approach to prepare NFS cathode for SIBs with both high energy density and fast‐charging ability.