bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Bayesian approach for analyzing crop yield response data with limited treatments
Authors: Cho Whoi , Lambert Dayton M. , Brorsen B. Wade , Maples Chellie H. , Fornah Alimamy , Raun William R. 
Published: April 2023

AbstractThis paper proposes a Bayesian multilevel modeling approach to incorporate response parameters from published studies into crop yield response estimation procedures when nonlimiting or limiting treatment levels are omitted or limited in agronomic experiments. Such circumstances may be encountered when data are from farmer‐led research, which may use nonstandardized experimental designs. The paper's focus is on maize yield response to nitrogen fertilizer, but the procedure is flexible enough to accommodate other factors that could affect crop yield response. A proof‐of‐concept Monte Carlo (MC) exercise supplements an empirical application. The MC simulation investigates the small sample properties of the proposed procedure. The empirical example uses field trial data for a maize planter experiment under different nitrogen (N) fertilizer rates. The planter trial compared mechanical planting methods to methods used in developing countries with limited access to mechanized planter technology. Some experiments had no check plots and all experiments lacked nonlimiting fertilizer rates. Linear and quadratic response functions with plateaus are used in the MC simulation and empirical application. MC results suggest that estimates were closest to true parameter values when priors for optimal N rates from published sources were used.
Healthy home food environments of pregnant Black women are shaped by food outlet access and participation in nutrition assistance programs
Authors: Nicholas Khristopher M. , Thompson Amanda L. , Wasser Heather M. , Bentley Margaret E. 
Published: April 2023

AbstractObjectivesImproving access to healthy food in Black communities is imperative to combat intergenerational health disparities. Pregnant Black women represent an especially vulnerable population to multiple (and overlapping) sources of socioeconomic and political disenfranchisement and thus for whom maternal nutrition is crucial. This study aimed to (1) define household food environment types, (2) determine whether the distribution of community food outlets is associated with these household food environment types, and (3) determine whether the community‐household food environment relationship differs by maternal education or participation in nutrition assistance programs.MethodsCross‐sectional data for pregnant Black women in North Carolina (n = 429) come from the Mothers & Others study, an obesity‐prevention randomized control trial, with linked spatial data on all community food outlets (n = 6312) in the study area in 2015. Factor analysis was used to define household food environment types. These factor scores were regressed on access metrics to community food outlets. Adjusted linear regressions tested interaction by maternal education and nutrition assistance programs.ResultsFour household food environment types were defined: Factor 1 (fresh fruits and vegetables (F/V), low snack), Factor 2 (canned F/V, sweet drinks), Factor 3 (dried/frozen F/V, candy), and Factor 4 (low F/V, soda). Having more convenience stores within 0.25 miles was associated with higher Factor 4 scores. No food outlets were associated with higher Factor 1 scores overall. However, SNAP or WIC participating households saw higher Factor 1 scores with increased access to supermarkets, convenience stores, and dollar stores.ConclusionsNutrition assistance programs play an important role as buffers against unhealthy community food environments which influence household food environments and maternal nutrition.
High‐fat diet and oral infection induced type 2 diabetes and obesity development under different genetic backgrounds
Authors: Lone Iqbal M. , Nun Nadav Ben , Ghnaim Aya , Schaefer Arne S. , Houri‐Haddad Yael , Iraqi Fuad A. 
Published: April 2023

AbstractBackgroundType 2 diabetes (T2D) is an adult‐onset and obese form of diabetes caused by an interplay between genetic, epigenetic, and environmental components. Here, we have assessed a cohort of 11 genetically different collaborative cross (CC) mouse lines comprised of both sexes for T2D and obesity developments in response to oral infection and high‐fat diet (HFD) challenges.MethodsMice were fed with either the HFD or the standard chow diet (control group) for 12 weeks starting at the age of 8 weeks. At week 5 of the experiment, half of the mice of each diet group were infected with Porphyromonas gingivalis and Fusobacterium nucleatum bacteria strains. Throughout the 12‐week experimental period, body weight (BW) was recorded biweekly, and intraperitoneal glucose tolerance tests were performed at weeks 6 and 12 of the experiment to evaluate the glucose tolerance status of mice.ResultsStatistical analysis has shown the significance of phenotypic variations between the CC lines, which have different genetic backgrounds and sex effects in different experimental groups. The heritability of the studied phenotypes was estimated and ranged between 0.45 and 0.85. We applied machine learning methods to make an early call for T2D and its prognosis. The results showed that classification with random forest could reach the highest accuracy classification (ACC = 0.91) when all the attributes were used.ConclusionUsing sex, diet, infection status, initial BW, and area under the curve (AUC) at week 6, we could classify the final phenotypes/outcomes at the end stage of the experiment (at 12 weeks).
Molecule Saturation Boosts Acetylene Semihydrogenation Activity and Selectivity on a Core‐Shell Ruthenium@Palladium Catalyst
Authors: Zhu Chuwei , Xu Wenlong , Liu Fang , Luo Jie , Lu Junling , Li Wei‐Xue 
Published: April 2023

AbstractIncreasing selectivity without the expense of activity is desired but challenging in heterogeneous catalysis. By revealing the molecule saturation and adsorption sensitivity on overlayer thickness, strain, and coordination of Pd‐based catalysts from first‐principles calculations, we designed a stable Pd monolayer (ML) catalyst on a Ru terrace to boost both activity and selectivity of acetylene semihydrogenation. The least saturated molecule is most sensitive to the change in catalyst electronic and geometric properties. By simultaneously compressing the Pd ML and exposing the high coordination sites, the adsorption of more saturated ethylene is considerably weakened to facilitate the desorption for high selectivity. The even stronger weakening to the least saturated acetylene drives its hydrogenation such that it is more exothermic, thereby boosting the activity. Tailoring the molecule saturation and its sensitivity to structure and composition provides a tool for rational design of efficient catalysts.
Modulation of Uptake and Reactivity of Nitrogen Dioxide in Metal‐Organic Framework Materials
Authors: Wang Zi , Sheveleva Alena M. , Lee Daniel , Chen Yinlin , Iuga Dinu , Franks W. Trent , Ma Yujie , Li Jiangnan , Li Lei , Cheng Yongqiang , Daemen Luke L. , Days Sarah J. , Ramirez‐Cuesta Anibal J. , Han Bing , Eggeman Alexander S. , McInnes Eric J. L. , Tuna Floriana , Yang Sihai , Schröder Martin 
Published: April 2023

AbstractWe report the modulation of reactivity of nitrogen dioxide (NO2) in a charged metal–organic framework (MOF) material, MFM‐305‐CH3 in which unbound N‐centres are methylated and the cationic charge counter‐balanced by Cl− ions in the pores. Uptake of NO2 into MFM‐305‐CH3 leads to reaction between NO2 and Cl− to give nitrosyl chloride (NOCl) and NO3− anions. A high dynamic uptake of 6.58 mmol g−1 at 298 K is observed for MFM‐305‐CH3 as measured using a flow of 500 ppm NO2 in He. In contrast, the analogous neutral material, MFM‐305, shows a much lower uptake of 2.38 mmol g−1. The binding domains and reactivity of adsorbed NO2 molecules within MFM‐305‐CH3 and MFM‐305 have been probed using in situ synchrotron X‐ray diffraction, inelastic neutron scattering and by electron paramagnetic resonance, high‐field solid‐state nuclear magnetic resonance and UV/Vis spectroscopies. The design of charged porous sorbents provides a new platform to control the reactivity of corrosive air pollutants.
Reconstruction of Metal Ions Extracted from Coal Gangue to Synthesize Cost‐effective Adsorbent for Highly Efficient Removal of Pollutants
Authors: Zhao Wen‐ting , Zhang Huan , Feng Ke , Wang Tian‐yang , Han Lei , Xing Hai‐feng , Huang Fei , Wang Wen‐bo 
Published: April 2023

AbstractAn emerging “one stone, three birds” strategy was proposed to realize the value‐added disposal of solid waste coal gangue (CG), the synthesis of superb adsorbent and the efficient decontamination of pollutants (i. e., dyes, heavy metals). In this process, the metal ions extrated from calcined coal gangue (CCG) was reconstituted by a one‐step hydrothermal process to yield porous polymetallic silicate adsorbent (named HECCGA8h). The adsorbent has a high adsorption capacity of 270.27 and 185.53 mg/g for methylene blue (MB) and Cd(II), respectively. In the actual waters, the removal rate of MB by this adsorbent reaches 99.8% (in Yangtze River water) and 99.42% (in Seawater), and the removal rate of Cd(II) reaches 99.11% (in Yangtze River water) and 92.52% (in Seawater), respectively. Thermokinetic analysis showed that the adsorption of MB by HECCGA8h is spontaneous and endothermic with increased entropy, and the adsorption of Cd(II) is spontaneous and exothermic. The adsorption of MB is mainly driven by synergism of hydrogen bond, electrostatic attraction and ion exchange, and the adsorption of Cd(II) is mainly driven by the complexation and ion exchange between the surface group of the adsorbent and Cd(II). This research provides a new way for the realization of “treating waste with waste”.
Neudefinition und Messung der Grenzschichtdicke an einer angeströmten Fläche – Ermittlung thermodynamischer und aerodynamischer Größen hieraus
Authors: Mayer Erhard , Norrefeldt Victor 
Published: April 2023

AbstractIn dieser Publikation werden die theoretische Grundlage sowie eine Messeinrichtung beschrieben, um den konvektiven Wärmeübergangskoeffizienten sowie die Scherspannung an einer angeströmten Wand zu messen. Hierzu misst das Convective Heattransfer Meter (CHM) den Temperaturabfall innerhalb der Strömungsgrenzschicht.Für exponentiell ablaufende zeitliche Prozesse ist die Zeitkonstante τ definiert als diejenige Zeitspanne, nach welcher eine Größe A(t) auf das 1/e‐fache des Ursprungswerts abgefallen ist, mit der Euler‐Zahl e = 2,718… Analog hierzu wird in diesem Beitrag für räumliche Prozesse mit exponentieller Annäherung anstelle der Zeitkonstanten τ die Grenzschichtdicke d vorgeschlagen. Ein solcher Prozess liegt im viskosen Grenzschichtbereich einer angeströmten Wand vor. Dabei erfährt die parallel zur Wandoberfläche verlaufende Strömung U(y) aufgrund der Viskosität der Luft und der Reibung der Wandoberfläche eine Abbremsung bis hin zur Haftbedingung an der Wandoberfläche. Die neu definierte Grenzschichtdicke d ist jener Abstand von der Wand y = d, für den gilt, dass die lokale Strömungsgeschwindigkeit U(y=d) auf das (1–e–1)‐fache der makroskopischen Strömungsgeschwindigkeit U(y=∞) angestiegen ist.Im Unterschied zur oft verwendeten Grenzschichtdicke δ, für die die Schwelle definitionsgemäß bei 99 % von U(y=∞) liegt, bietet die Neudefinition der Grenzschichtdicke d Vorteile hinsichtlich deren Messbarkeit sowie der Ermittlung der konvektiven Wärmeübertragung und der Ermittlung der Scherspannung an angeströmten Körpern.
The influence of lifestyle changes (diet, exercise and stress reduction) on prostate cancer tumour biology and patient outcomes: A systematic review
Authors: Dovey Zach , Horowitz Amir , Waingankar Nikhil 
Published: April 2023

AbstractBackgroundThe mostly indolent natural history of prostate cancer (PCa) provides an opportunity for men to explore the benefits of lifestyle interventions. Current evidence suggests appropriate changes in lifestyle including diet, physical activity (PA) and stress reduction with or without dietary supplements may improve both disease outcomes and patient's mental health.ObjectiveThis article aims to review the current evidence on the benefits of all lifestyle programmes for PCa patients including those aimed at reducing obesity and stress, explore their affect on tumour biology and highlight any biomarkers that have clinical utility.Evidence acquisitionEvidence was obtained from PubMed and Web of Science using keywords for each section on the affects of lifestyle interventions on (a) mental health, (b) disease outcomes and (c) biomarkers in PCa patients. PRISMA guidelines were used to gather the evidence for these three sections (15, 44 and 16 publications, respectively).Evidence synthesisFor lifestyle studies focused on mental health, 10/15 demonstrated a positive influence, although for those programmes focused on PA it was 7/8. Similarly for oncological outcomes, 26/44 studies demonstrated a positive influence, although when PA was included or the primary focus, it was 11/13. Complete blood count (CBC)‐derived inflammatory biomarkers show promise, as do inflammatory cytokines; however, a deeper understanding of their molecular biology in relation to PCa oncogenesis is required (16 studies reviewed).ConclusionsMaking PCa‐specific recommendations on lifestyle interventions is difficult on the current evidence. Nevertheless, notwithstanding the heterogeneity of patient populations and interventions, the evidence that dietary changes and PA may improve both mental health and oncological outcomes is compelling, especially for moderate to vigorous PA. The results for dietary supplements are inconsistent, and although some biomarkers show promise, significantly more research is required before they have clinical utility.
A tale of two genomes: What drives mitonuclear discordance in asexual lineages of a freshwater snail?
Authors: Neiman Maurine , Sharbrough Joel 
Published: April 2023

AbstractWe use genomic information to tell us stories of evolutionary origins. But what does it mean when different genomes report wildly different accounts of lineage history? This genomic “discordance” can be a consequence of a fascinating suite of natural history and evolutionary phenomena, from the different inheritance mechanisms of nuclear versus cytoplasmic (mitochondrial and plastid) genomes to hybridization and introgression to horizontal transfer. Here, we explore how we can use these distinct genomic stories to provide new insights into the maintenance of sexual reproduction, one of the most important unanswered questions in biology. We focus on the strikingly distinct nuclear versus mitochondrial versions of the story surrounding the origin and maintenance of asexual lineages in Potamopyrgus antipodarum, a New Zealand freshwater snail. While key questions remain unresolved, these data inspire multiple testable hypotheses that can be powerfully applied across a broad range of taxa toward a deeper understanding of the causes and consequences of mitonuclear discordance, the maintenance of sex, and the origin of new asexual lineages.
A closed, autologous bioprocess optimized for TCR‐T cell therapies
Authors: Liu Yijun , Zah Eugenia , Arbelaez Carlos , Kim Haejin , Gros Edwige , Buck Ranelle , Cox Kayley , Kim Sungeun , Kopp Martina , Henckels Kathryn , Stevens Jennitte 
Published: April 2023

AbstractAutologous cell therapy has proven to be an effective treatment for hematological malignancies. Cell therapies for solid tumors are on the horizon, however the high cost and complexity of manufacturing these therapies remain a challenge. Routinely used open steps to transfer cells and reagents through unit operations further burden the workflow reducing efficiency and increasing the chance for human error. Here we describe a fully closed, autologous bioprocess generating engineered TCR‐T cells. This bioprocess yielded 5–12 × 10e9 TCR‐expressing T cells, transduced at low multiplicity of infections, within 7–10 days, and cells exhibited an enriched memory T‐cell phenotype and enhanced metabolic fitness. It was demonstrated that activating, transducing, and expanding leukapheresed cells in a bioreactor without any T‐cell or peripheral blood mononuclear cell enrichment steps had a high level of T‐cell purity (~97%). Several critical process parameters of the bioreactor, including culturing at a high cell density (7e6 cells/mL), adjusting rocking agitations during phases of scale‐up, lowering glycolysis through the addition of 2‐deoxy‐
d‐glucose, and modulating interleukin‐2 levels, were investigated on their roles in regulating transduction efficiency, cell growth, and T‐cell fitness such as T‐cell memory phenotype and resistance to activation‐induced cell death. The bioprocess described herein supports scale‐out feasibility by enabling the processing of multiple patients' batches in parallel within a Grade C cleanroom.
Cycling performance of silicon‐carbon composite anodes enhanced through phosphate surface treatment
Authors: Gobena Hana T. , Lai Samson Y. , Koposov Alexey Y. , Maehlen Jan P. , Ghamouss Fouad , Lemordant Daniel 
Published: April 2023

AbstractSilicon (Si)‐based anodes have long been viewed as the next promising solution to improve the performance of modern lithium‐ion batteries. However, the poor cycling stability of Si‐based anodes impedes their application and calls for solutions for further improvements. In the present work, the incorporation of phosphate groups on the surface of an amorphous Si‐carbon composite (a‐Si/C) has been achieved by a hydrothermal reaction using phosphoric acid and sodium dihydrogen phosphate at pH = 2. Different levels of the surface P‐doping have been realized using reaction times (2, 4, and 8 h) at two different phosphate concentrations. The presence of phosphate groups on the particle's surface has been confirmed by energy‐dispersive X‐ray, infrared, and Raman spectroscopy. The cycling stability of the P‐treated a‐Si/C composites has been significantly improved when using lithium bis(trifluoromethanesulfonyl)imide as a salt in ether‐based solvents mixture compared to a conventional electrolyte for Si‐based anodes (LiPF6 in carbonate‐based solvents). Coulombic efficiencies as high as 99% have been reached after five charge/discharge cycles for almost all phosphate‐treated materials. The 4 h P‐treated a‐Si/C composite electrode exhibits the best reversible capacity of 1598 mAh g−1 after 200 cycles demonstrated in half‐cells using an ether‐based electrolyte.
Study on the Adsorption of Cr3+ by Peanut Shell: Adsorption Kinetics, Thermodynamics, and Isotherm Properties
Authors: Li Xiao‐Dong , Zhai Qing‐Zhou 
Published: April 2023

AbstractThe pollution of heavy metals in soil to the environment is becoming more and more serious, resulting in the reduction of crop production and the occurrence of medical accidents. In order to remove heavy metal ions from soil and reduce the harm of heavy metals to the environment, modified peanut shell was used to adsorb Cr3+ in this article. The effects of different adsorption conditions on the adsorption rate and adsorption capacity of Cr3+ on ZnCl2 modified peanut shell were studied, the best adsorption conditions were explored, and the relationship of kinetics, thermodynamics and adsorption isotherm properties of adsorption process were explored. The results showed that the optimum adsorption pH value, dosage, initial concentration, adsorption temperature and contact time of ZnCl2 modified peanut shell were 2.5, 2.5 g/L, 75 μg/mL, 25 °C and 40 min, respectively. The prepared materials were characterized and analyzed by scanning electron microscope (SEM) and X‐ray diffraction (XRD) analyzer. It was concluded that the modified peanut shell had a good adsorption capacity to Cr3+. The kinetic study showed that the adsorption process of Cr3+ on peanut shell modified by zinc chloride was in accordance with the quasi‐second‐order kinetic model. The adsorption process belonged to exothermic reaction and belonged to spontaneous reaction process. In summary, it is proved that zinc chloride modified peanut shell can efficiently adsorb Cr3+, which can be used for the treatment of heavy metal wastes in industry, which is beneficial to environmental protection and avoid heavy metal pollution.
Contributions of Chemical Content and Biological Activity to Plant Taxonomy Based on the FourAlliumL. Taxa (Sect.Cupanioscordum‐ Amaryllidaceae)
Authors: Ekşi Bona Gülnur , Akalın Çiftçi Gülşen , Demirci Betül , Münevver Pınar Nur , Acar Şahin Aydan , Koçyiğit Mine , Bona Mehmet , Mine Gençler Özkan Ayşe 
Published: April 2023

AbstractGarlic and onions are used as food and for medicinal purposes worldwide.AlliumL. species are rich in bioactive organosulphur compounds that exhibit many biological activities like anticancer, antimicrobial, antihypertensive, antidiabetic activities. In this study, macro‐ and micromorphological characteristics of fourAlliumtaxa were examined and the results suggested thatA. callimischonsubsp.haemostictumwas the outgroup to sect.Cupanioscordum. Also, for the genusAllium, which is a taxonomically difficult genus, the hypothesis that chemical content and bioactivity can also be used taxonomically in addition to micro and macromorphological characters has been questioned. The bulb extract was analyzed to determine their volatile compositions and anticancer activities against human breast cancer, human cervical cancer, and rat glioma cells for the first time in the literature. To detect the volatiles, the Head Space‐Solid Phase Micro Extraction method was used followed by Gas Chromatography‐Mass Spectrometry. The main compounds were found as dimethyl disulfide that (36.9 %, 63.8 %, 81.9 %, 12.2 %) and methyl (methylthio)‐methyl disulfide (10.8 %, 6.9 %, 14.9 %, 60.0 %) forA. peroninianum,A. hirtovaginatumandA. callidyction, respectively. Additionally, methyl‐trans‐propenyl disulfide is detected forA. peroniniaum(36 %). As a result, all extracts have shown significant efficacy against MCF‐7 cells depending on applied concentrations. The treatment of MCF‐7 cells for 24 h with 10, 50, 200, or 400 μg/mL ethanolic bulb extract of fourAlliumspecies resulted in DNA synthesis inhibition. Survival rates forA. peroninianumwas 51.3 %, 49.7 %, 42.2 %, 42.0 %, forA. callimischonsubsp. haemostictum62.5 %, 63.0 %, 23.2 %, 22 %, forA. hirtovaginatum52.9 %, 42.2 %, 42.4 %, 39.9 %, forA. callidyction51.8 %, 43.2 %, 39.1 %, 31.3 %, for cisplatin 59.6 %, 59.9 %, 50,9 %, 48.2 %, respectively. Moreover, taxonomic evaluation according to biochemical compounds and bioactivities is almost in agreement with that made according to micro and macromorphological characters.
Mechanism of the Anti‐Influenza Functions of Guizhi Granules Based on Network Pharmacology, Molecular Docking, and in Vitro Experiments
Authors: Ling Wei , Li Xiang , Liu Xiaoyu , Wu Qian , Wang Weilong , Meng Jin , Sun Baochang , Lv Binbin 
Published: April 2023

AbstractGuizhi granules mainly treat colds and improve overall health. They are widely used in clinical practice, but their protective effect and anti‐inflammatory mechanism against influenza are unclear. In this study, the therapeutic effect of Guizhi granules on influenza was verified in vitro. The active compounds, targets, and cellular pathways of Guizhi granules against influenza were predicted using network pharmacology. The protein‐protein interaction and component‐target networks identified 5 core targets (JUN, TNF‐α, RELA, AKT1, and MAPK1) and components (dihydrocapsaicin, kumatakenin, calycosin, licochalcone A, and berberine). GO and KEGG enrichment analyses revealed the anti‐influenza pathways of Guizhi granules as antiviral and anti‐inflammatory pathways. Molecular docking further verified that the core targets and components have good or strong binding activity. Therefore, the active ingredients, targets, and molecular mechanisms of Guizhi granules involved in influenza treatment were elucidated.