bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anti-viral and Anti-inflammatory Isoflavonoids from Ukrainian Iris aphylla Rhizomes: Structure-Activity Relationship Coupled with ChemGPS-NP Analysis
Authors: Mykhailenko Olha , Hsieh Chung-Fan , El-Shazly Mohamed , Nikishin Alexander , Kovalyov Vladimir , Shynkarenko Pavlo , Ivanauskas Liudas , Chen Bing-Hung , Horng Jim-Tong , Hwang Tsong-Long , Georgiyants Victoriya , Korinek Michal 
Published: March 2023

AbstractDried Iris rhizomes have been used in Chinese and European traditional medicine for the treatment of various diseases such as bacterial infections, cancer, and inflammation, as well
as for being astringent, laxative, and diuretic agents. Eighteen phenolic compounds including some rare secondary metabolites, such as irisolidone, kikkalidone, irigenin, irisolone,
germanaism B, kaempferol, and xanthone mangiferin, were isolated for the first time from Iris aphylla rhizomes. The hydroethanolic Iris aphylla extract and some of its isolated
constituents showed protective effects against influenza H1N1 and enterovirus D68 and anti-inflammatory activity in human neutrophils. The promising anti-influenza effect of apigenin
(13, almost 100% inhibition at 50 µM), kaempferol (14, 92%), and quercetin (15, 48%) were further confirmed by neuraminidase inhibitory assay. Irisolidone (1,
almost 100% inhibition at 50 µM), kikkalidone (5, 93%), and kaempferol (14, 83%) showed promising anti-enterovirus D68 activity in vitro. The identified compounds were
plotted using ChemGPS-NP to correlate the observed activity of the isolated phenolic compounds with the in-house database of anti-influenza and anti-enterovirus agents. Our results indicated
that the hydroethanolic Iris aphylla extract and Iris phenolics hold the potential to be developed for the management of seasonal pandemics of influenza and enterovirus
infections.
Posterior Segment Involvement in Infantile Nephropathic Cystinosis – A Review
Authors: Keidel Leonie Franziska , Schworm Benedikt , Hohenfellner Katharina , Kruse Franziska , Priglinger Siegfried , Luft Nikolaus , Priglinger Claudia 
Published: March 2023

AbstractCystinosis is a rare lysosomal storage disease with a prevalence of 1 : 100 000 – 1 : 200 000 cases. It is caused by biallelic mutations in the CTNS gene, which encodes cystinosin, that
transport cystine out of the lysosomes. Due to its dysfunction, cystine crystals accumulate in the lysosomes and ultimately cause apoptosis of the cell. Since cystinosin is ubiquitously
present in the body, cystine crystals are deposited in every body structure and lead to the dysfunction of various organ systems in the course of time. Cystine crystals deposited in the
cornea are a clinical hallmark of the disease, while there is less awareness of concomitant posterior segment alterations. Symmetrical pigment epithelial mottling and patches of
depigmentation frequently start in the periphery and progress towards the posterior pole and can be encountered upon fundus biomicroscopy. Spectral-domain optical coherence tomography
(SD-OCT) is an elegant tool for visualizing chorioretinal cystine crystals at the posterior pole. An SD-OCT-based clinical grading of the severity of the chorioretinal manifestation can
potentially be applied as a biomarker for systemic disease status and for monitoring oral therapy adherence in the future. Along with previous histological examinations, it may also give
information about the location of cystine crystals in the choroid and retina. This review aims to increase the awareness of vision-threatening retinal and choroidal changes in cystinosis and
the concomitant findings in SD-OCT.
Germline Mutations Landscape in a Cohort of the State of Minas Gerais, Brazil, in Patients Who Underwent Genetic Counseling for Gynecological and Breast Cancer
Authors: Carvalho Camila Martins de , Braga Letícia da Conceição , Silva Luciana Maria , Chami Anisse Marques , Silva Filho Agnaldo Lopes da 
Published: March 2023

Abstract
Objective The present study evaluated the profile of germline mutations present in patients who underwent genetic counseling for risk assessment for breast cancer (BC), ovarian cancer (OC), and endometrial cancer (EC) with a possible hereditary pattern.
Methods Medical records of 382 patients who underwent genetic counseling after signing an informed consent form were analyzed. A total of 55.76% of patients (213/382) were symptomatic (personal history of cancer), and 44.24% (169/382) were asymptomatic (absence of the disease). The variables analyzed were age, sex, place of birth, personal or family history of BC, OC, EC, as well as other types of cancer associated with hereditary syndromes. The Human Genome Variation Society (HGVS) nomenclature guidelines were used to name the variants, and their biological significance was determined by comparing 11 databases.
Results We identified 53 distinct mutations: 29 pathogenic variants, 13 variants of undetermined significance (VUS), and 11 benign. The most frequent mutations were BRCA1 c.470_471delCT, BRCA1 c.4675 + 1G > T, and BRCA2 c.2T> G. Furthermore, 21 variants appear to have been described for the first time in Brazil. In addition to BRCA1/2 mutations, variants in other genes related to hereditary syndromes that predispose to gynecological cancers were found.
Conclusion This study allowed a deeper understanding of the main mutations identified in families in the state of Minas Gerais and demonstrates the need to assess the family history of non-gynecological cancer for risk assessment of BC, OC, and EC. Moreover, it is an effort that contributes to population studies to evaluate the cancer risk mutation profile in Brazil.
Quality of Life and Depression Conditions of Women with Gestational Diabetes during Pregnancy and Postpartum Period
Authors: Doğan Reyhan Aydin , Beji Nezihe Kizilkaya 
Published: March 2023

Abstract
Objective The study was conducted to determine the quality of life and depression of women with gestational diabetes during pregnancy and the postpartum period.
Methods 100 pregnant women with gestational diabetes and 100 healthy pregnant women were included in the present study. Data were obtained from pregnant women in their third trimester who agreed to take part in the study. The data was collected during the third trimester and six to eight weeks after the baby was born. The data were obtained by socio-demographic characteristics form, postpartum data collection form, the MOS 36 Item Short Form Health Survey and Center for Epidemiologic Studies Depression Scale (CESD).
Results The mean age of pregnant women with gestational diabetes in the study was the same as the average age of healthy pregnant women. The CESD score of pregnant women with gestational diabetes was 26,77 ± 4,85 while the corresponding score was 25,19 ± 4,43 for healthy women. Additionally, the score in the postpartum period was 32.47 ± 5.94 for pregnant women with gestational diabetes and 35.47 ± 8.33 for healthy pregnant women. CESD scores were found to be higher than the cut-off score of 16 in both groups, and the mean scores increased during the postpartum period.
Conclusion During the postpartum period, the quality of life of pregnant women with gestational diabetes was affected more negatively than healthy pregnant women. Depressive symptoms of women with both gestational diabetes and healthy pregnancy were found to be high in pregnancy and postpartum periods.
Simultaneously achieving high performance of thermal stability and power consumption via doping yttrium in Sn15Sb85 thin film
Authors: Xu Shengqing , Wu Weihua , Gu Han , Zhou Xiaochen , Zhu Xiaoqin , Zhai Jiwei , Song Sannian , Song Zhitang 
Published: March 2023

Abstract
The effects of yttrium dopants on the phase change behavior and microstructure of Sn15Sb85 films have been systematically investigated. The yttrium-doped Sn15Sb85 film has the higher phase transition temperature, ten year data retention ability and crystallization activation energy, which represent a great improvement in thermal stability and data retention. X-ray diffraction, transmission electron microscopy and x-ray photoelectron spectroscopy reveal that the amorphous Sn and Y components restrict the grain growth and decrease the grain size. Raman mode typically associated with Sb is altered when the substance crystallized. Atomic force microscopy results show that the surface morphology of the doped films becomes smoother. T-shaped phase change storage cells based on yttrium-doped Sn15Sb85 films exhibit the lower power consumption. The results demonstrate that the crystallization characteristics of Sn15Sb85 film can be tuned and optimized through the yttrium dopant for the excellent performances of phase change memory.
Traveling wave solutions of a class of multi-species non-cooperative reaction–diffusion systems
*
Authors: Ai Shangbing , Du Yihong , Jiao Yujuan , Peng Rui 
Published: March 2023

Abstract
In this paper we establish a sharp existence result on weak traveling wave solutions for a general class of multi-species reaction–diffusion systems. Moreover, the minimal speed of the traveling waves is explicitly determined. Such a weak traveling wave solution connects the predator-free equilibrium point E
0 at

x
=
−
∞

but needs not to connect the coexistence equilibrium

E
∗

at

x
=
∞

. We apply this result to three important non-cooperative systems: the classical diffusive SIS system for the spread of infectious disease, a predator–prey system with age structure and a generalised Lotka–Volterra predator–prey system of one predator species feeding on n prey species, and prove with the aid of Lyapunov functions and the LaSalle invariance principle that their weak traveling wave solutions are actually traveling wave solutions that connect

E
∗

at

x
=
∞

. For the SIS system and the generalised Lotka–Volterra predator–prey system, we develop additional techniques to establish the boundedness of their weak traveling wave solutions before applying the LaSalle’s invariance principle.
Absence of magnetic interactions in Ni–Nb ferromagnet–superconductor bilayers
Authors: Satchell Nathan , Quarterman P , Borchers J A , Burnell Gavin , Birge Norman O 
Published: March 2023

AbstractStudies of ferromagnet-superconductor hybrid systems have uncovered magnetic interactions between the competing electronic orderings. The electromagnetic (EM) proximity effect predicts the formation of a spontaneous vector potential inside a superconductor placed in proximity to a ferromagnet. In this work, we use a Nb superconducting layer and Ni ferromagnetic layer to test for such magnetic interactions. We use the complementary, but independent, techniques of polarized neutron reflectometry and detection Josephson junctions to probe the magnetic response inside the superconducting layer at close to zero applied field. In this condition, Meissner screening is negligible, so our measurements examine only additional magnetic and screening contributions from proximity effects. We report the absence of any signals originating from EM proximity effect in zero applied field. Our observations indicate that either EM proximity effect is below the detection resolution of both of our experiments or may indicate a new phenomenon that requires extension of current theory. From our measurements, we estimate a limit of the size of the zero field EM proximity effect in our Ni–Nb samples to be ±0.27 mT.
Be optical lattice clocks with the fractional Stark shift up to the level of 10−19
Authors: Wu Lei , Wang Xia , Wang Ting , Jiang Jun , Dong Chenzhong 
Published: March 2023

Abstract
The energy levels and electric dipole (

E
1

) matrix elements of the ground state and low-lying excited states of Be atoms are calculated using the relativistic configuration interaction plus core polarization (RCICP) method. The static and dynamic

E
1

, magnetic dipole (

M
1

) and electric quadrupole (

E
2

) polarizabilities as well as the hyperpolarizabilities of the

2

s
2

1

S
0

and

2
s
2
p

3

P
0

states are determined. Two magic wavelengths, 300.03 and 252.28 nm, of

2

s
2

1

S
0

→
2
s
2
p

3

P
0

clock transition are found. Then, the multipolar and nonlinear Stark shifts of the clock transition at the magic wavelength are discussed in detail. We find that when the laser intensity I is in the range of 14.3–15.9 kW cm−2 and the detuning δ (the frequency detuning of the lattice laser frequency relative to the magic frequency) is in the range of 40.7–40.9 MHz, the fractional Stark shifts of the clock transition are less than 1.0 × 10−18. While, when I is in the range of 15.01–15.46 kW cm−2 and δ is in the range of 40.73–40.76 MHz, the fractional Stark shifts are lower than 1.0 × 10−19.
Spatially-resolved dynamic sampling of different phasic magnetic resonances of nanoparticle ensembles in a magnetotactic bacterium Magnetospirillum magnetotacticum
Authors: Feggeler Thomas , Lill Johanna , Günzing Damian , Meckenstock Ralf , Spoddig Detlef , Efremova Maria V , Wintz Sebastian , Weigand Markus , Zingsem Benjamin W , Farle Michael , Wende Heiko , Ollefs Katharina J , Ohldag Hendrik 
Published: March 2023

Abstract
Nanoscaled magnetic particle ensembles are promising building blocks for realizing magnon based binary logic. Element-specific real-space monitoring of magnetic resonance modes with sampling rates in the GHz regime is imperative for the experimental verification of future complex magnonic devices. Here we present the observation of different phasic magnetic resonance modes using the element-specific technique of time-resolved scanning transmission x-ray microscopy within a chain of dipolarly coupled Fe3O4 nanoparticles (40–50 nm particle size) inside a single cell of a magnetotactic bacterium Magnetospirillum magnetotacticum. The particles are probed with 25 nm resolution at the Fe L3 x-ray absorption edge in response to a microwave excitation of 4.07 GHz. A plethora of resonance modes is observed within multiple particle segments oscillating in- and out-of-phase, well resembled by micromagnetic simulations.
Shaping effects on the geodesic acoustic mode in tokamaks
Authors: Chen Zhe , Ren Haijun 
Published: March 2023

Abstract
The geodesic acoustic mode (GAM) is investigated with gyro-kinetic equations in Miller local equilibrium model for shaped tokamak plasmas with an arbitrary elongation κ and a finite triangularity δ. In particular, the effects of triangularity on GAM frequency and damping rate are analyzed both analytically and numerically. The asymptotic analytical and exact numerical results both show that the frequency almost linearly increases with the triangularity but increases relatively more slowly for a negative δ, which agree well with the TCV observation on the trend. The analytical results clearly claim that the triangularity effect strength is dependent on the inverse aspect ratio

ϵ

and Shafranov shift gradient

Δ

′

, while the numerical results indicate that the safety factor q also has a significant impact on the triangularity effects. In addition, the damping rate increases rapidly with triangularity when q is not too large and then saturates when δ is above about 0.3.
Shell-Model Study of Nuclear Weak Rates relevant to Astrophysical Processes in Stars
Authors: Suzuki IToshio , Shimizu Noritaka , Tsunoda Yusuke , Otsuka Takaharu , Nomoto Kenichi 
Published: March 2023

AbstractNew shell-model Hamiltonians which can successfully describe spin responses in nuclei are used to evaluate nuclear weak rates in stellar environments. The e-capture andβ-decay rates for the nuclear pair with31Mg-31Al, in the island of inversion, which have been pointed out to be important for the cooling of neutron star crusts, are studied by shell-model calculations with the effective interaction insd-pfshell obtained by the extended Kuo-Krenciglowa (EKK) method. The weak rates induced by the Gamow-Teller transitions between the low-lying states in the nuclear pair lead to a nuclear Urca process. The spin-dipole strengths and e-capture rates for78Ni are evaluated by shell-model with fullpf-sdgshells including up to 5p-5h excitations outside filling configurations of78Ni. The e-capture rates obtained are compared with RPA calculations and the effective rate formula. Weak rates for the second-forbidden transition in20Ne are evaluated by the multipole expansion method of Walecka as well as the Behrens-Bühring method within sd-shell. Difference in the rates between the two methods is found to be rather small as far as the conserved-vector-current (CVC) relation is satisfied. Possible important contributions of the forbidden transition to the heating of the ONeMg core by double e-captures on20Ne in a late stage of the evolution of the core and implications on the final fate of the core, whether core-collapse or thermonuclear explosion, are discussed.
Conjectured Hole States (7Be, 19F) and p-h states (8Be) of the CSM
Authors: Gai Moshe 
Published: March 2023

Abstract
The remarkable success of the Algebraic Cluster Model (ACM) to describe the N=Z even-even light nuclei, 8Be, 12C, 16O and 20Ne, and the neighbouring nuclei with one particle added, 9Be, 9B, 13C, 21Ne and 21Na, using the Cluster Shell Model (CSM), lead us to consider the phenomenology of data on conjectured hole states of the CSM in 7Be and 19F, and conjectured high lying particle-hole states (p-h) in 8Be.
We propose the first application of the Cluster Shell Model (CSM) of Della Rocca and Iachello to conjectured p-h states in 8Be. We demonstrate a few essential phenomenological features of the CSM in 8Be: 1) All predicted conjectured p-h states of the CSM, and only the predicted p-h states, are observed near thresholds and up to 19.5 MeV in 8Be. 2) The states are observed in the predicted order, with positive parity states below negative parity states. 3) Some of the conjectured p-h states are already known to have the predicted rotational structure of the deformed p-h states. 4) The rotational structures observed at high excitations in the conjectured p-h bands in 8Be, resemble the ground state bands of 8Be, 9Be and 9B, with similar moment of inertia.
Based on these observations we contemplate new measurements of the spectroscopy of 8Be at energies above 19.5 MeV, where our knowledge of states in 8Be is incomplete. We examine the observed B(M1)s and B(E2)s in these nuclei and contemplate a measurement of the B(E2) of the iso-baric Analog transition in 8Li.
Research on Intrinsic and Environmental Conditions Hazard Analysis Methods for Civil Aircraft
Authors: Yu Jie 
Published: March 2023

Abstract
SAE ARP 4761 stipulates that an area safety analysis must be performed in every area of the aircraft to ensure the safety requirements of the equipment. The study proposes the Intrinsic Hazard Analysis and environmental conditions hazard analysis methods to identify potential neighboring hazard sources, assess the weakness of the area, and solve the problem of incomplete input of area safety analysis. The IEHA analysis method has been verified and applied in the actual type of work, which plays the role of systematic and comprehensive identification of hazard sources and discovery of potential risks, and has practical engineering application for the development of domestic large aircraft. It provides a good theoretical basis and technical reserve for establishing the method and process of civil aircraft safety design verification.
Research on Cutting Parameters Database Based on Spacecraft Product Characteristics
Authors: Liu Hanliang , Yang Kai , Zhao Wei , Hu Xingping , Feng Changxi , Wu Di , Diao Zhenkuan , Qiao Kun , Wu Fei 
Published: March 2023

Abstract
Cutting parameters affect the production and processing efficiency and the quality of products. The characteristics of single-piece and small-batch production of spacecraft products result in a large number of cutting parameters. Due to the lack of centralized management methods, cutting parameters in the production site are not unified, which seriously affects the processing efficiency and quality of products. In response to a large number of cutting parameters and the lack of centralized management, the production resource library is completed by establishing a spacecraft product feature pedigree. Taking the product characteristics as the carrier, the production resources as the optional factors, and the forces in the cutting process as the evaluation criteria, the whole life management mechanism of cutting parameters is established to unify the cutting parameters in the production process and complete the establishment of the cutting parameter database. The interface between the programming platform and the cutting parameters library is developed for a low reuse rate of cutting parameters. With typical features as the carrier, the cutting parameters are packaged and transmitted to the programming platform to provide reliable cutting parameters for feature automatic programming, which improves the reuse rate of cutting parameters and simplifies the numerical control programming operation. The results show that the reuse times of cutting parameters are more than 8000 times, effectively ensuring the machining efficiency and quality consistency of products.
Numerical Investigation of Cooling Characteristics of a Double-sided Composite Impeller with a New Micro Gas Turbine
Authors: Huang Jiaxin , Zhang Cheng , Long Yongqiang 
Published: March 2023

Abstract
In order to achieve a micro gas turbine engine with higher thermal cycle parameters and higher aerodynamic performance, a double-sided composite impeller has been designed innovatively based on structures combined, thermal cycle process integration, and existing impingement cooling technology with the help of additive manufacturing technology, which is expected to increase the turbine inlet temperature and break the material limit. The double-sided composite impeller is numerically simulated by the method of gas-thermal coupling. The results showed that: First, compared with the turbine without cooling, the maximum turbine wall temperature and average turbine wall temperature of the turbine with impingement cooling technology decreased by more than 166.33K and 213.79K, respectively, and the minimum cooling efficiency and the average cooling efficiency of the turbine with impingement cooling technology increased by more than 34.32% and 46.8% respectively. Second, the physical property differences of nickel alloy materials in the same category have no obvious influence on the cooling characteristics of turbines. Finally, for GH4220 material, the turbine inlet temperature can be increased by more than 520K when the turbine material is kept in a stable working temperature range. This study opens the way for the higher turbine inlet temperature or the use of low-cost, lightweight materials such as titanium alloys.
Kinematic Analysis of 5-axis CNC Laser Processing Machine Based on GSN Control Card
Authors: Sun Yingjie , Yao Kun , Yuan Minghai , Mao Kefu 
Published: March 2023

Abstract
The five axis CNC laser machining machine is widely used in the processing industry with high efficiency and precision and other advantages. Based on the basic principle of kinematics theory on the multi-body system, this paper describes the homogeneous coordinate transformation law of the five-axis laser machining machine tool based on GSN control card, and analyzes the solution of the motion trajectory and converts it into the incremental data of the position of each axis in the coordinate system of the machine tool, which solves the correctness, universality and automation of the numerical control system. It provides a powerful help for the five axis CNC laser machining machine based on GSN control card.