bluuebunny/crossref_metadata_2025_split huggingface dataset:
From CO2 to Electricity: Photosynthesis‐Based Functionally Cooperating Mini‐Generator
Authors: Wang Dan , Wang Jiamin , Ming Rui , Liu Chongxian , Tian Pan , Cheng Mengjiao , Xiao Meng , Shi Feng 
Published: April 2023

AbstractRecently, the global warming and climate changes have aroused focus of attentions. Hence, there is an increased demand to capture, utilize, and sequestrate the greenhouse gas, i.e., carbon dioxide (CO2), for promising applications. Functionally cooperating mini‐generators are a kind of self‐propelled smart devices that can harvest environmental energy and convert it to electricity through Faraday's law. But traditional mini‐generators are based on an energy‐consuming process appealing for energy consumption from high‐grade state to low‐grade one. Herein, a mini‐generator based on photosynthesis with CO2 as the fuel is designed. The generator can convert the internal energy of O2 bubbles produced by photosynthesis to electricity. This is an energy conversion from the lowest energy state to the applicable energy. Based on the high‐efficiency photosynthesis of hydrophyte, spontaneously water‐dissolved CO2 can afford to induce regularly cycled surfacing‐diving motion, and the induced electrical output can simultaneously actuate multiple electronic components. Owing to the weather sensitivity of the photosynthesis, the system can be used to monitor weather through reading the changes of output electrical signals. By integrating the artificial smart device with natural plants, this research will promote the applications of miniaturized devices toward green development.
Bacteria‐Targeted Combined with Photothermal/NO Nanoparticles for the Treatment and Diagnosis of MRSA Infection In Vivo
Authors: Lv Kai , Li Guowei , Pan Xiangjun , Liu Luxuan , Chen Ziheng , Zhang Yu , Xu Hao , Ma Dong 
Published: April 2023

AbstractCurrently, undeveloped diagnosis and delayed treatment of bacteria‐infected sites in vivo not only expand the risk of tissue infection but are also a major clinical cause of multiple drug‐resistant bacterial infections. Herein, an efficient nanoplatform for near‐infrared (NIR)‐light‐controlled release and bacteria‐targeted delivery of nitric oxide (NO) combined with photothermal therapy (PTT) is presented. Using maltotriose‐decorated mesoporous polydopamine (MPDA‐Mal) and BNN6, a smart antibacterial (B@MPDA‐Mal) is developed to combine bacterial targeting, gas‐controlled release, and PTT. Utilizing bacteria's unique maltodextrin transport system, B@MPDA‐Mal can accurately distinguish bacterial infection from sterile inflammation and target the bacteria‐infected sites for efficient drug enrichment. Moreover, NIR‐light causes MPDA to generate heat, which not only effectively induces BNN6 to produce NO, but also raises the temperature to harm the bacteria further. NO/photothermal combination therapy effectively eliminates biofilm and drug‐resistant bacteria. The myositis model of methicillin‐resistant Staphylococcus aureus infection is established and indicates that B@MPDA‐Mal can successfully eradicate inflammation and abscesses in mice. Meanwhile, magnetic resonance imaging technology is used to monitor the treatment procedure and healing outcomes. Given the aforementioned advantages, the smart antibacterial nanoplatform B@MPDA‐Mal can be used as a potential therapeutic tool in the biomedical field against drug‐resistant bacterial infections.
Biomimetic Spun Silk Ionotronic Fibers for Intelligent Discrimination of Motions and Tactile Stimuli
Authors: Cao Xinyi , Ye Chao , Cao Leitao , Shan Yicheng , Ren Jing , Ling Shengjie 
Published: April 2023

AbstractInnovation in the ionotronics field has significantly accelerated the development of ultraflexible devices and machines. However, it is still challenging to develop efficient ionotronic‐based fibers with necessary stretchability, resilience, and conductivity due to inherent conflict in producing spinning dopes with both high polymer and ion concentrations and low viscosities. Inspired by the liquid crystalline spinning of animal silk, this study circumvents the inherent tradeoff in other spinning methods by dry spinning a nematic silk microfibril dope solution. The liquid crystalline texture allows the spinning dope to flow through the spinneret and form free‐standing fibers under minimal external forces. The resultant silk‐sourced ionotronic fibers (SSIFs) are highly stretchable, tough, resilient, and fatigue‐resistant. These mechanical advantages ensure a rapid and recoverable electromechanical response of SSIFs to kinematic deformations. Further, the incorporation of SSIFs into core–shell triboelectric nanogenerator fibers provides outstanding stable and sensitive triboelectric response to precisely and sensitively perceive small pressures. Moreover, by implementing a combination of machine learning and Internet of Things techniques, the SSIFs can sort objects made of different materials. With these structural, processing, performance, and functional merits, the SSIFs prepared herein are expected to be applied in human–machine interfaces.
Clearwing‐Inspired Invisible Thin Membrane
Authors: Kang Seong Min , Choi Ji Seong , Hong Jongwoo , Lee Ok Hyeon , Kang Insun 
Published: March 2023

AbstractAdvanced highly transparent films or membranes are required for diverse optical applications, including ophthalmology and the display industry. In general, bioinspired engineering is the most promising technology for obtaining highly transparent surfaces. This study proposes a novel perfluoropolyether (PFPE) highly transparent thin membrane with nanopatterns on both sides of the surface, inspired by the wings (clearwing) of Greta‐oto. PFPE is a superior material for achieving this goal because of its low refractive index and low surface energy. A clearwing‐inspired antireflective membrane (CAM) composed of PFPE is fabricated using a well‐designed polymer replica method. CAM exhibits outstanding optical properties and intriguing demonstrations of invisible trap sensors, both in air and water, with long‐term stability.
Recent Development in Topological Polymer Electrolytes for Rechargeable Lithium Batteries
Authors: Liu Yu , Zeng Qinghui , Li Zhenfeng , Chen Anqi , Guan Jiazhu , Wang Honghao , Wang Shi , Zhang Liaoyun 
Published: March 2023

AbstractSolid polymer electrolytes (SPEs) are still being considered as a candidate to replace liquid electrolytes for high‐safety and flexible lithium batteries due to their superiorities including light‐weight, good flexibility, and shape versatility. However, inefficient ion transportation of linear polymer electrolytes is still the biggest challenge. To improve ion transport capacity, developing novel polymer electrolytes are supposed to be an effective strategy. Nonlinear topological structures such as hyperbranched, star‐shaped, comb‐like, and brush‐like types have highly branched features. Compared with linear polymer electrolytes, topological polymer electrolytes possess more functional groups, lower crystallization, glass transition temperature, and better solubility. Especially, a large number of functional groups are beneficial to dissociation of lithium salt for improving the ion conductivity. Furthermore, topological polymers have strong design ability to meet the requirements of comprehensive performances of SPEs. In this review, the recent development in topological polymer electrolytes is summarized and their design thought is analyzed. Outlooks are also provided for the development of future SPEs. It is expected that this review can raise a strong interest in the structural design of advanced polymer electrolyte, which can give inspirations for future research on novel SPEs and promote the development of next‐generation high‐safety flexible energy storage devices.
The resident experience with psychological safety during interprofessional critical event debriefings
Authors: Hitchner Lily , Yore Mackensie , Burk Charney , Mason Jessica , Sawtelle Vohra Stacy 
Published: April 2023

AbstractObjectivesInterprofessional feedback and teamwork skills training are important in graduate medical education. Critical event debriefing is a unique interprofessional team training opportunity in the emergency department. While potentially educational, these varied, high‐stakes events can threaten psychological safety for learners. This is a qualitative study of emergency medicine resident physicians’ experience of interprofessional feedback during critical event debriefing to characterize factors that impact their psychological safety.MethodsThe authors conduced semistructured interviews with resident physicians who were the physician team leader during a critical event debriefing. Interviews were coded and themes were generated using a general inductive approach and concepts from social ecological theory.ResultsEight residents were interviewed. The findings suggest that cultivating a safe learning environment for residents during debriefings involves the following: (1) allowing space for validating statements, (2) supporting strong interprofessional relationships, (3) providing structured opportunities for interprofessional learning, (4) encouraging attendings to model vulnerability, (5) standardizing the process of debriefing, (6) rejecting unprofessional behavior, and (7) creating the time and space for the process in the workplace.ConclusionsGiven the numerous intrapersonal, interpersonal, and institutional factors at play, educators should be sensitive to times when a resident cannot engage due to unaddressed threats to their psychological safety. Educators can address these threats in real time and over the course of a resident's training to enhance psychological safety and the potential educational impact of critical event debriefing.
The association between dietary patterns, plasma lipid profiles, and inflammatory potential in a vascular dementia cohort
Authors: Dai Jun , Chan Daniel Kam Yin , Chan Richard O. , Hirani Vasant , Xu Ying Hua , Braidy Nady 
Published: April 2023

AbstractBackgroundInflammation and altered lipid dyshomeostasis have been implicated in the pathogenesis of Alzheimer's disease and vascular dementia.ObjectiveTo determine if there are any associations between dietary patterns, plasma lipid profiles, and inflammatory potential in a vascular dementia cohort.MethodsOne hundred fifty participants (36 subjects with Vascular Dementia and 114 healthy controls) from two Australian teaching hospitals completed a cross‐sectional survey examining their dietary and lifestyle patterns. Each participant's diet was further evaluated using the Empirical Dietary Inflammatory Index. Some participants also donated blood samples for lipidomic analysis.ResultsAfter adjusting for age, education, and socioeconomic status, participants with vascular dementia tend to have higher lipid profiles, do less exercise, and engage less frequently in social interaction, educational, or reading activities. They also tend to consume more deep‐fried food and full‐fat dairy compared to control subjects. However, there was no difference in Empirical Dietary Inflammatory Index between the two groups after adjusting for age, education, and socioeconomic status.ConclusionOur findings suggest a graded inverse association between healthy lifestyle factors and vascular dementia.
Use of the Arctic Sun™ 5000 targeted temperature management system to achieve rewarming during a prolonged hypothermic cardiorespiratory arrest
Authors: Grewal A. , Thomas R. 
Published: March 2023

SummaryCardiorespiratory arrest due to severe hypothermia may require prolonged cardiopulmonary resuscitation whilst the patient is rewarmed. There are reported cases of successful resuscitation with good neurological outcomes after prolonged arrests and resuscitation up to 9 h. However, in the majority of these cases, extracorporeal life support was used to maintain perfusion and rewarm the patient. Here, we report a case of successful cardiopulmonary resuscitation lasting 6.5 h, following cardiac arrest secondary to severe hypothermia, with rewarming using an Arctic Sun™ 5000. The Arctic Sun 5000 is a targeted temperature management device which is conventionally used to prevent hyperthermia post‐cardiac arrest. In this report, we discuss the reasons why the device was used in this case and the effects of severe hypothermia on cardiac arrest management. We believe that this is the longest reported successful cardiopulmonary resuscitation in a severely hypothermic patient without the use of extracorporeal life support.
NQO1 regulates expression and alternative splicing of apoptotic genes associated with Alzheimer's disease in PC12 cells
Authors: Du Yingshi , Liu Gejing , Chen Dong , Yang Jinggang , Wang Jing , Sun Yue , Zhang Qian , Liu Yongming 
Published: April 2023

AbstractPurposeAlzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive memory loss and cognitive dysfunction. Quinone oxidoreductase 1 (NQO1) is an antioxidant enzyme that plays an important role in controlling cellular redox state, whose expression is altered in the brain tissues of AD patients. In addition to its traditional antioxidant effects, NQO1 also acts as a multifunctional RNA‐binding protein involved in posttranscriptional regulation. Whether the RNA‐binding activity of NQO1 influences AD pathology has not been investigated yet.MethodsThe RNA‐binding functions of NQO1 in rat pheochromocytoma (PC12) cells were investigated using siRNA knockdown followed by total RNA sequencing. Reverse transcription quantitative polymerase chain reaction was performed to explore the impact of NQO1 on the transcription and alternative splicing of apoptotic genes.ResultsNQO1 knockdown led to a significant increase in cellular apoptosis. Genes involved in certain apoptosis pathways, such as positive regulation of apoptotic processes and mitogen‐activated protein kinase signaling, were under global transcriptional and alternative splicing regulation. NQO1 regulated the transcription of apoptotic genes Cryab, Lgmn, Ngf, Apoe, Brd7, and Stat3, as well as the alternative splicing of apoptotic genes BIN1, Picalm, and Fyn.ConclusionOur findings suggest that NQO1 participates in the pathology of AD by regulating the expression and alternative splicing of the genes involved in apoptosis. These results extend our understanding of NQO1 in apoptotic pathways at the posttranscriptional level in AD.
Prevalence of cancer therapy cardiotoxicity as assessed by imaging procedures: A scoping review
Authors: Cantoni Valeria , Green Roberta , Assante Roberta , D'Antonio Adriana , Maio Francesca , Criscuolo Emanuele , Bologna Roberto , Petretta Mario , Cuocolo Alberto , Acampa Wanda 
Published: March 2023

AbstractBackgroundAdvances in treatment and optimization of chemotherapy protocols have greatly improved survival in cancer patients. Unfortunately, treatment can cause a reduction in left ventricular (LV) ejection fraction (EF) leading to cancer therapy‐related cardiac dysfunction (CTRCD). We conducted a scoping review of published literature in order to identify and summarize the reported prevalence of cardiotoxicity evaluated by noninvasive imaging procedures in a wide‐ranging of patients referred to cancer treatment as chemotherapy and/or radiation therapy.MethodsDifferent databases were checked (PubMed, Embase, and Web of Science) to identify studies published from January 2000 to June 2021. Articles were included if they reported data on LVEF evaluation in oncological patients treated with chemotherapeutic agents and/or radiotherapy, measured by echocardiography and/or nuclear or cardiac magnetic resonance imaging test, providing criteria of CTRCD evaluation such as the specific threshold for LVEF decrease.ResultsFrom 963 citations identified, 46 articles, comprising 6841 patients, met the criteria for the inclusion in the scoping review. The summary prevalence of CTRCD as assessed by imaging procedures in the studies reviewed was 17% (95% confidence interval, 14–20).ConclusionsThe results of our scoping review endorse the recommendations regarding imaging modalities to ensure identification of cardiotoxicity in patients undergoing cancer therapies. However, to improve patient management, more homogeneous CTRCD evaluation studies are required, reporting a detailed clinical assessment of the patient before, during and after treatment.
Cancer incidence after asthma diagnosis: Evidence from a large clinical research network in the United States
Authors: Guo Yi , Bian Jiang , Chen Zhaoyi , Fishe Jennifer N. , Zhang Dongyu , Braithwaite Dejana , George Thomas J. , Shenkman Elizabeth A. , Licht Jonathan D. 
Published: March 2023

AbstractBackgroundPrior studies on the association between asthma and cancer show inconsistent results. This study aimed to generate additional evidence on the association between asthma and cancer, both overall, and by cancer type, in the United States.MethodWe conducted a retrospective cohort study using 2012–2020 electronic health records and claims data in the OneFlorida+ clinical research network. Our study population included a cohort of adult patients with asthma (n = 90,021) and a matching cohort of adult patients without asthma (n = 270,063). We built Cox proportional hazards models to examine the association between asthma diagnosis and subsequent cancer risk.ResultsOur results showed that asthma patients were more likely to develop cancer compared to patients without asthma in multivariable analysis (hazard ratio [HR] = 1.36, 99% confidence interval [CI] = 1.29–1.44). Elevated cancer risk was observed in asthma patients without (HR = 1.60; 99% CI: 1.50–1.71) or with (HR = 1.11; 99% CI: 1.03–1.21) inhaled steroid use. However, in analyses of specific cancer types, cancer risk was elevated for nine of 13 cancers in asthma patients without inhaled steroid use but only for two of 13 cancers in asthma patients with inhaled steroid use, suggesting a protective effect of inhaled steroid use on cancer.ConclusionThis is the first study to report a positive association between asthma and overall cancer risk in the US population. More in‐depth studies using real‐word data are needed to further explore the causal mechanisms of asthma on cancer risk.
Transcatheter versus surgical treatment for isolated superior sinus venosus atrial septal defect
Authors: Brancato Federica , Stephenson Natasha , Rosenthal Eric , Hansen Jan H. , Jones Matthew I. , Qureshi Shakeel , Austin Conal , Speggiorin Simone , Caner Salih , Butera Gianfranco 
Published: April 2023

AbstractBackgroundThe superior sinus venosus atrial septal defect is a congenital communication between the left and right atria. Open surgical approach by patch closure has historically been the only treatment option. Recently, a transcatheter approach has been developed. This study aims to compare the efficacy and safety of surgical and transcatheter approach in treatment of sinus venosus atrial septal defect.MethodsBetween March 2010 and December 2020, 58 patients (median age: 45.4, range 14.8−73.8) underwent either surgical or transcatheter correction of superior sinus venosus atrial septal defect with partial anomalous pulmonary venous drainage.ResultsTwenty‐four patients (median age: 35.4, range 14.8−66.8) underwent surgery while 34 patients (median age: 46.8, range 15.5−73.8) had a transcatheter treatment. During the catheterization era, 41 patients was considered suitable for a transcatheter closure. In 5 patients, surgery was the patient's or referring physician's choice. In 2 cases, the procedure was unsuccessful; the remaining 34 were successfully closed (94.4% of cases). Intensive care unit stay (median of 1 day, range 0.5−4, vs. 0, range 0−2, p < 0.0001) and hospital stay (median 7 days, range 2−15 vs. 2 days, range 1−12, p < 0.0001), were significantly longer in the surgery group. Total early complication rate, consisted on procedural and in‐hospital complication, were higher in the surgical group (62.5% vs. 23.5%; p = 0.005). However, complications in both groups were clinically mild. At follow‐up, a small residual shunt was present in 6 patients (surgery group: 2 pts; catheterization group: 4 pts; p: NS). Imaging studies showed significant improvement of right ventricular size and unobstructed pulmonary venous return in all patients. No late complications occurred at follow‐up.ConclusionsTranscatheter correction of sinus venosus atrial septal defect is effective and safe in selected patients and may be considered as a valid alternative to surgery.
Reactivated herpetic gingivostomatitis with secondary herpes‐associated erythema multiforme and oral candidiasis post‐COVID infection: A case report
Authors: Lee Haeseong , Davoudi Jouliana , Vistoso Anette , Khalifeh Mohammad , Sedghizadeh Parish 
Published: March 2023

AbstractThe presence and reactivation of oral lesions such as herpetic gingivostomatitis, erythema multiforme, and candidiasis in a COVID‐19 recovered patient could be related to COVID‐19s profound role in immune dysregulation or related therapies.
Evaluation of spectral collection strategies for identification of Dalbergia spp. using handheld laser‐induced breakdown spectroscopy
Authors: Celani Caelin P. , McCormick Rachel A. , Speed Amelia M. , Johnston William , Jordan James A. , Coplen Tyler B. , Booksh Karl S. 
Published: March 2023

AbstractThe illegal timber trade has significant impact on the survival of endangered tropical hardwood species like Dalbergia spp. (rosewood), a world‐wide protected genus from the Convention on International Trade in Endangered Species of Wild Fauna and Flora (CITES). Due to increased threat to Dalbergia spp., and lack of action to reduce threats, port of entry analysis methods are required to identify Dalbergia spp. Handheld laser‐induced breakdown spectroscopy (LIBS) has been shown to be capable of identifying species and establishing provenance of Dalbergia spp. and other tropical hardwoods, but analysis methods for this work have yet to be investigated in detail. The present work investigates five well‐known algorithms—partial least squares discriminant analysis (PLS‐DA), classification and regression trees (CART), k‐nearest neighbor (k‐NN), random forest (RF), and support vector machine (SVM)—two training/test set sampling regimes, and data collection at two signal‐to‐noise (S/N) ratios to assess the potential for handheld LIBS analyses. Additionally, imbalanced classes are addressed. For this application, SVM and RF yield near identical results (though RF takes nearly 100 longer to compute), while the S/N ratio has a significant effect on model success assuming all else is equal. It was found that forming a training set with replicate low S/N analyses can perform as well as higher precision training sets for true prediction, even if the predicted samples have low signal to noise! This work confirms handheld LIBS analyzers can provide a viable method for classification of hardwood species, even within the same genus.