bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quality of Family Planning Services and Associated Factors Among Reproductive Age Women Attending Family Planning Unit at Public Health Facilities in Dire Dawa, Eastern Ethiopia, 2021
Authors: Abera Legesse , Ejigu Ezira , Hailu Mickiale , Tadesse Daniel , Omer Abdu 
Published: December 2022

Abstract
Introduction: Improving the quality of care has been a necessary goal for family planning programs worldwide. Even though extensive work has been done, the contraceptive prevalence rate is still low (41% in Ethiopia, 30.5% in Dire Dawa) and the unmet need for contraception is high (26%) in Ethiopia. Moreover, quality of care in family planning services has an important role in increasing coverage of services and program sustainability.
Objective: To assess quality of family planning services and associated factors among reproductive age women attending family planning unit in public health facilities in Dire Dawa, Eastern Ethiopia, 2021.
Methods:A facility-based cross-sectional study was conducted among reproductive-age women attending a family planning unit in Dire Dawa, Eastern Ethiopia, from September 1-30/2021. A total of 576 clients were selected by systematic random sampling and interviewed using a pre-tested structured questionnaire. SPSS version 24 was used to analyze the data, which included descriptive statistics, binary and multivariate logistic regression analyses. To determine the presence of an association between dependent and independent variables, AOR, P-value 0.05, and 95% CI were used.
Results: A total of 576 clients participated in the study and provided a response rate of 99%. The overall satisfaction of clients with family planning services was 79.0%. Client education, facility opening hours, maintaining privacy, demonstrating how to use the method, and discussing with husbands are significantly associated with client satisfaction.
Conclusion and recommendation: This study revealed that more than one-fifth of the clients were unsatisfied with the service they received. Clients’ education, facility opening hour, maintained privacy, discussion with husband, and demonstration of how to use the methods were associated with client satisfaction. Health providers should consistently utilize information, education, and communication materials during consultation sessions.
A new equation of four infinite series and sums by using a generalized recurrence relation
Authors: Louiz Akram 
Published: December 2022

Abstract
Motivated by the fundamental presence of mathematics in all engineering and scientific fields, I made this
mathematical article in order to answer many of my personal questions which are also not answered questions
in mathematics. This is a mathematical article that proves a usefulrecurrence relation that is very useful for
mathematics demonstrations. The article proves also that four infinite series are equivalent. Hence, this article
opens new opportunities to demonstrate and develop new mathematical findings and observations. The demonstrated
formulas of this article can also be very useful for all the fields that apply mathematics and especially
infinite series and sums.
Update of global maps of Alisov’s climate classification
Authors: Shimabukuro Ryu , Tomita Tomohiko , Fukui Ken-ichi 
Published: December 2022

Abstract
Alisov’s climate classification was proposed in 1954, and it focuses on the January–July changes in large-scale air mass zones and their fronts. In this study, data clustering by machine learning was applied to global reanalysis data to quantitatively and objectively determine air mass zones, which were then used to classify the global climate. The differences in air mass zones between two half-year seasons were used to determine climatic zones, which were then subdivided into continental or maritime climatic regions or according to east–west climatic differences. This study renews Alisov’s climate classification for the first time in almost 70 years and applies data-driven machine learning to establishing a standard for genetic climate classification.
Prevalence of and relevant factors for depression and anxiety symptoms among pregnant women on the eastern seaboard of China in the post-COVID-19 era
Authors: Yang Haidong , Pan Yangyang , Chen Wanming , Yang Xu , Liu Bin , Yuan Nian , Zhang Xiaobin 
Published: December 2022

Abstract
Background
Antenatal depression and anxiety symptoms may have negative consequences for both mothers and offspring, and upward trends in the prevalence of these symptoms were especially apparent during the COVID-19 epidemic. The purpose of this study was to evaluate the prevalence of and relevant factors influencing depressive and anxiety symptoms in Chinese pregnant women in the post-COVID-19 era.
Methods
We conducted an online survey of 1,963 pregnant women in Jiangsu Province, using a cross-sectional design, and collected their general demographic data. The nine-item Patient Health Questionnaire 9 (PHQ-9) was used to evaluate depression symptoms, and the seven-item Generalized Anxiety Disorder 7 (GAD-7) was used to measure anxiety symptoms.
Results
The prevalence of reported antenatal depressive symptoms, anxiety symptoms, and depression combined with anxiety symptoms was 25.2%, 27.9%, and 18.6%, respectively. Of the respondents, prevalence of moderate to severe depression, anxiety, and combined symptoms was 7.9%, 7.7%, and 4.7%, respectively. Binary logistic regression analysis demonstrated that age, low level of education, rural area, unemployment, pregnancy complications, poor marital relationship, and fair household income were positively association with both depressive and anxiety symptoms (all P < 0.05). The proportion of women reporting anxiety symptoms in the third trimester was 1.895-fold higher than in first trimester. Parity was not a relevant factor for depression and anxiety symptoms (all P > 0.05).
Conclusions
In the post-COVID-19 era, the prevalence of depression and anxiety symptoms in pregnant women was higher than expected, and it is vital to establish hospital, community, and family psychological health screening systems based on relevant factors and enhance early preventive measures.
Melanin-like polydopamine nanoparticles mediating anti-inflammatory and rescuing synaptic loss for inflammatory depression therapy
Authors: Zhu Tingting , Wang He , Gu Hanwen , Ju Lingsha , Wu Xinmiao , Pan Weitong , Zhao Mingming , Yang Jianjun , Liu Panmiao 
Published: December 2022

Abstract
Inflammatory depression is closely related to the activation of the immune system in the peripheral and central nervous system (CNS). Due to the lack of drugs, the treatment of inflammatory depression has been an urgent problem to be solved. According to the anti-oxidative and anti-inflammatory properties, melanin-like polydopamine nanoparticles (PDA NPs), may have a good therapeutic effect on the inflammatory depression. Hence, we investigated the therapeutic effect of PDA NPs on lipopolysaccharide (LPS)-induced inflammatory depression in this study. The PDA NPs with diameter of ~250 nm were prepared by the simplest one-step synthesis method. Applying these PDA NPs to the LPS-induced inflammatory depression mice model confirmed that PDA NPs significantly reversed the depression behavior of mice. Further exploration found that, therapeutic effects of PDA NPs were attributed to their antagonism to the peripheral inflammation induced by LPS. More importantly, PDA NPs also crossed the blood-brain barrier to reach the CNS, and inhibited microglial activation via the TLR4/NF-κB signaling pathway, restoring neuronal synapse loss, which consequently attenuated depression-like behaviors induced by LPS. The PDA NPs were also confirmed to show good biocompatibility both in vivo and in vitro. Our study therefore provided the great promise of PDA NPs as a biocompatible nano-drug in rescuing inflammatory depression.
Funding for the Construction of "Double First-Class" Universities in China Research on Core Performance Objectives and Indicator Setting
Authors: Si Chen 
Published: December 2022

Abstract
The performance evaluation of "double first-class" construction funds of colleges and universities in China reflects not only the necessary requirement of implementing comprehensive budget performance management, but also the realistic demand of colleges and universities to achieve their development goals. Performance objectives and indicator setting are the core and key to the full implementation of budget performance management. The framework of the core performance objectives and index system of the "double first-class" construction projects will be constructed in this study from the characteristics of the "double first-class" construction projects of Chinese universities. To realize this purpose, various performance evaluation tools such as Balanced Scorecard (BSC), Key Performance Indicators (KPI), etc. will be applied. Furthermore, we will take the process of formulating the performance indicators for the "double first-class" construction funds of university B as an example to verify the scientificity and operability of the constructed performance evaluation index system framework.
Association between childhood trauma, cognition, and psychosocial function in a large sample of partially or fully remitted patients with bipolar disorder and healthy participants
Authors: Miskowiak Kamilla Woznica , Hansen Katrine Bang , Mariegaard Johanna , Kessing Lars Vedel 
Published: December 2022

Abstract
Background: Childhood trauma (CT) are frequently reported by patients with bipolar disorder (BD), but it is unclear whether and how CT contribute to patients’ cognitive and psychosocial impairments. We aimed to examine the impact of CT on cognition and psychosocial functioning in a large sample of 345 patients with BD and 183 healthy control participants (HC) using the Childhood Trauma Questionnaire, neurocognitive tests and ratings of mood symptoms and functioning.
Results: Patients showed broad cognitive impairments across memory, attention and executive function and functional disability despite being in partial or full remission and had higher levels of CT than HC. Higher levels of CT correlated with impairments across almost all cognitive domains and lower psychosocial functioning across BD patients and HC. Of these, the associations between CT and poorer working memory and lower psychosocial functioning, respectively, prevailed after adjusting for clinical and demographical variables. Diagnosis of BD and estimated verbal intelligence did not moderate these associations. Analysis of CT sub-categories showed that working memory impairments were related particularly to childhood physical and emotional abuse, while psychosocial difficulties were related to physical and emotional neglect.
Conclusions: CT may have negative implications for working memory and psychosocial functioning across both BD and healthy populations. If the findings are replicated, this would suggest that early interventions that reduce the frequency of CT in vulnerable families may aid children’s cognitive and psychosocial development.
Grow Newtonian rigid inertia into parameter repetitiveness memory equivalent bio-inertia by gravitationally degenerating eigenstates on a surface tension region for growth turnover selection inheritance
Authors: Lai Yi Yu 
Published: December 2022

Abstract
Note: Please see pdf for full abstract with equations.
Inversion energy is parameter-against-gravity-internal-fluctuation, the non-simultaneousness in correlated internal fluctuations is quantizing time. Modified Newtonian Laws are, first: 𝑑/𝑑𝑥 cosx =−𝑠𝑖𝑛𝑥, 𝑑/𝑑𝑥 sinx = 𝑐𝑜𝑠𝑥; second: 𝐹⃗=𝑚∙𝑎⃗+|𝑚𝑔⃗∫𝑡𝑔𝜃⋅𝑑𝜃 ⟩↿⇂ third: Wavelength =2/𝑛 L, frequency = n𝑓0. Bio-systems are topological spaces that can process input objects into inversion energy for entropy-control by repetitiveness memory, the capability of equivalent procured inversion energy with memorized trigonometric repetitiveness by quantizing time is bio-inertia. Evolution grows the trigonometric folding equivalent capacity of a topological space. Schrödinger equation has only quantized energy but hasn’t quantized time thus inducing quantum collapse, we then write down equation 𝑯̂𝜓=𝑬𝜓 + Σn|cos(1/𝑛 𝑥)⟩ to grow eigenstates on certain surface tension regions to procure quantizing time for lifespan. Originating from elastic quantum scale differences between Planck regions and surface tension regions, bio quantum duality grows in vivo cross folded-surface tension region flow. Life relies on trigonometric negentropy procured from elastic entropy generation ground condensates and physically inherit by bio quantum growth turnover selection.
Toxic chromium in water and the effects on the human body: a systematic review
Authors: Georgaki Maria-Nefeli , Charalambous Marianna 
Published: December 2022

Abstract
Both in developed and developing countries, there is a growing concern about the dangerous hexavalent chromium, in the consumption of drinking water. Hexavalent chromium is recognized to have a negative impact on the human body, both in the short and long term. The purpose of this study is to evaluate the relationship between hexavalent chromium in water and its impact on human health. A systematic review of the international literature is applied, according to the instructions of PRISMA protocol, in the databases PubMed and Scopus, for the years 2005–2022. The systematic literature review was conducted using inclusion and exclusion criteria, and appropriate keywords for exposure and outcome. A total of 18 studies met all inclusion criteria. Most research concludes that hexavalent chromium is a risk factor for humans, as opposed to trivalent chromium who is a protective factor. A study indicates the consumption of drinking water with high concentrations of hexavalent chromium, as a protective factor for human life, while eight of the total studies suggest hexavalent chromium as a potential risk factor. It is necessary to clarify the origin, the mode of action, and the negative impact has on human health, to create appropriate preventive and intervention measures.
Hydrogeochemical investigation and groundwater quality assessment toward ‘smart city planning in a coastal aquifer, India
Authors: Biswas George , Arshad Mohd , Saba Naseem Us , Arora Tanvi , Ahmed Shakeel 
Published: December 2022

Abstract
This paper aims to understand the general background of groundwater quality that must be considered for the 'smart city' planning of Surat city. Twenty-Six water samples collected from bore wells of the city were analyzed. The results showed that water is alkaline, as pH varies from 7.6 to 9.2. The concentration of Cl− and Na+ are correlated with EC. The highest levels of Cl− and Na+ are found near the coastal region (predominantly northwestern); Piper trilinear diagram shows 52% of samples are Na-HCO3− type and 48% NaCl type. WQI shows that most samples are potable for drinking, but a few samples from the western part are not suitable for drinking. SAR, Na%, and PI results show that most samples are suitable for irrigation. The corrosivity index indicates that 50% of samples have a CR &gt; 1(unsafe zone), and the rest are within the safe limit. The relationship of WQI with different water quality parameters revealed that groundwater quality has deteriorated in the city's western part, which may be due to seawater intrusion in the aquifer. This work gives a basic idea of groundwater quality, which will help make Surat a smart city.
Sensoriamento remoto aplicado ao monitoramento de macrófitas no reservatório de Santa Cruz – Apodi/RN
Authors: Feitosa Alex Pinheiro 
Published: December 2022

Este trabalho objetivou avaliar a distribuição espacial e temporal por meio de técnicas de sensoriamento remoto e a quantificação da existência de macrófitas aquáticas no espelho d’água na barragem de Santa Cruz no Rio Grande do Norte, nos anos de 2015, 2016 e 2017. O estudo foi desenvolvido no período de baixa pluviosidade, por meio do uso técnicas de geoprocessamento, mais especificamente do NDVI (Normalized Difference Vegetation Index) e classificação supervisionada Minimum Distance (Distância Mínima). Para elaboração dos mapas e gráficos, foram realizadas as seguintes ações: seleção das imagens do satélite LANDSAT-8/OLI, calibração radiométrica, correção atmosférica, reprojeção, definição do limite, recorte da área, NDVI e classificação supervisionada. Os produtos obtidos através da classificação supervisionada, subsidiada pelos mapas de NDVI, indicaram para um aumento de 32 % na área ocupada por macrófitas aquáticas de 2015 e 2016, enquanto que foi observada uma diminuição de 38 % entre os anos de 2016 e 2017.
Programas Performativos Pandêmicos como registro e continuidade dos processos de criação em dança durante a pandemia
Authors: Gasparini Igor 
Published: December 2022

Como artista da dança, diretor do T.F.Style Cia de Dança, este texto surge a partir das experiências artísticas desenvolvidas pelo núcleo desde 2002 e que, nos últimos anos, desdobrou-se no aprofundamento da pesquisa corpo-cidade e de outras possibilidades de mediação obra-público. Em 2020, com a interrupção das ações presenciais, o núcleo teve de encontrar outras formas de continuar a pesquisa em andamento, dividindo suas ações entre grupo de estudos, vivências práticas pela tela e realização de programas performativos, com objetivo de reforçar os ELOs à distância. Se, por um lado, o isolamento social impediu que os artistas continuassem a pesquisa de corpo a corpo, abriu possibilidades de investigação de outras relações com o espaço: o espaço-casa e o espaço-tela. E a pesquisa de corpo em 360º encontrou outros desafios nas telas bidimensionais. Neste momento de isolamento social, são muitas as incertezas para nós artistas da cena. Como cultivar a presença mediada pela tela? Ainda é possível realizar as “artes vivas” em meio a tantas mortes? Como manter os ELOs e a pesquisa em dança neste período de isolamento? Como a experiência de cidade em um contexto pós-pandêmico também transforma nosso fazer? Em março de 2020, quando decidimos pela continuidade dos encontros dessa outra forma, sugeri ao grupo o texto “Programas Performativos: o corpo em experiência”, de Eleonora Fabião, primeiramente, para leitura e discussão, mas que também pudesse estimular a realização de protocolos de criação. Essa iniciativa permaneceu viva ao longo de todo o ano de 2020 e, inspirados pela artista e pesquisadora, surge o blog Programas Performativos Pandêmicos pelo anseio de tornar público parte desses protocolos realizados ao longo da pandemia, além de demarcar historicamente o momento atual e registrar os processos de criação do núcleo durante a pandemia da COVID-19.
Identification of Novel Zika Virus Inhibitors: A Screening using Thiosemicarbazones
and Thiazoles Templates
Authors: de Moraes Gomes Paulo André Teixeira , Barros Freitas Luiz Alberto , Pessoa Siqueira Luciana Rabelo , da Conceição Juliana Maria , dos Santos Ignes Regina , Pinto Aline Ferreira , de Melo Silva Vanessa Gouveia , Nunes Janine Siqueira , de Oliveira Cardoso Marcos Veríssimo , Pena Lindomar José , Lima Leite Ana Cristina 
Published: December 2022

Background:
Zika virus (ZIKV) remains an important cause of congenital infection, fetal microcephaly, and Guillain-Barré syndrome in the population. In 2016, WHO declared a cluster of microcephaly cases and other neurological disorders reported as a global public health emergency in Brazil. There is still no specific treatment for Zika virus fever, only palliative care. Therefore, there is a need for new therapies against this disease. According to the literature, thiosemicarbazone, phthalimide and thiazole are privileged structures with several biological activities, including antiviral activity against various viruses.

Objective:
Based on this, this work presents an antiviral screening using previously synthesized compounds derived from thiosemicarbazone, phthalimide, and thiazole as new hits active against ZIKV.

Methods:
After synthesis and characterization, all compounds were submitted to Cytotoxicity by MTT and Antiviral activity against ZIKV assays.

Results:
Compounds 63, 64, 65, and 73 exhibited major reductions in the ZIKV title from this evaluation. Compounds 63 (99.74%), 64 (99.77%), 65 (99.92%), and 73 (99.21%) showed a higher inhibition than the standard 6MMPr (98.74%) at the CC20 dose. These results revealed new chemical entities with anti-ZIKV activity.

Conclusion:
These derivatives are promising candidates for further assays. In addition, the current approach brings a new privileged scaffolding, which may drive future drug discovery for ZIKV.
Exploring the Multitarget Potential of Iridoids: Advances and Applications
Authors: Chawla Pooja A. , Grover Parul , Mehta Lovekesh , Malhotra Anjleena , Kapoor Garima , Nagarajan Kandasamy , Kumar Parvin , Chawla Viney 
Published: December 2022

Abstract:
Iridoids are secondary plant metabolites that are multitarget compounds active against various diseases. Iridoids are structurally classified into iridoid glycosides and non-glycosidic iri-doids according to the presence or absence of intramolecular glycosidic bonds; additionally, iridoid glycosides can be further subdivided into carbocyclic iridoids and secoiridoids. These monoterpe-noids belong to the cyclopentan[c]-pyran system, which has a wide range of biological activities, including antiviral, anticancer, antiplasmodial, neuroprotective, anti-thrombolytic, antitrypanoso-mal, antidiabetic, hepatoprotective, anti-oxidant, antihyperlipidemic and anti-inflammatory proper-ties. The basic chemical structure of iridoids in plants (the iridoid ring scaffold) is biosynthesized in plants by the enzyme iridoid synthase using 8-oxogeranial as a substrate. With advances in phyto-chemical research, many iridoid compounds with novel structure and outstanding activity have been identified in recent years. Biologically active iridoid derivatives have been found in a variety of plant families, including Plantaginaceae, Rubiaceae, Verbenaceae, and Scrophulariaceae. Iridoids have the potential of modulating many biological events in various diseases. This review highlights the multitarget potential of iridoids and includes a compilation of recent publications on the phar-macology of iridoids. Several in vitro and in vivo models used, along with the results, are also in-cluded in the paper. This paper's systematic summary was created by searching for relevant iridoid material on websites such as Google Scholar, PubMed, SciFinder Scholar, Science Direct, and oth-ers.The compilation will provide the researchers with a thorough understanding of iridoid and its congeners, which will further help in designing a large number of potential compounds with a strong impact on curing various diseases.