bluuebunny/crossref_metadata_2025_split huggingface dataset:
Novel Aminocoumarin Dye for Sustainable Polyester Fabric Dyeing: Synthesis and Performance Evaluation
Authors: Akyıldız Sinem Hazal , Özdemir Mücahit , Özkan Beyza Nur , Güler Eray Metin , Gültekin Cenkkut , Yalçın Bahattin 
Published: May 2023

Abstract

The textile sector is regarded as one of the most environmentally damaging industries in the world. There are several factors that contribute to the unsustainability of textiles and clothing, including the use of hazardous chemicals, high water and energy consumption, generation of solid and gaseous waste, consumption of fuel for transportation to remote locations, and use of non-biodegradable packaging materials. Moreover, it is estimated that textile treatments such as dyeing and finishing are responsible for 20% of all water pollution. Especially textile dyes can pose significant harm to the environment and human health. Disperse dyeing of polyester requires large quantities of chemicals. Additionally, some disperse dyes contain hazardous chemicals that can cause skin irritation and respiratory problems in workers and consumers. In this study, we synthesized 7-ethylamino-3-acetylcoumarin dye using the Knoevenagel reaction, and the dyeing process of polyester fabric with the novel type of this coumarin dye was applied. The structural and chemical analyses were performed using micro-FTIR, FTIR, NMR, UV-Vis spectroscopy, and cell viability. The evaluation of the coloured fabric's fastness against washing, rubbing, and an artificial light source representative of natural daylight (D65) were also carried out using standard methods. It was found that the best result came from dyeing polyester with coumarin in an acidic condition for 45 minutes and then washing it reductively. The study provides valuable insights into the development of new dyes with improved properties and their application to fabric dyeing, which can contribute to the sustainability and environmental impact of the textile industry.
Evaluator’s alignment as an important indicator of reliability of assessment procedure for recognizing the good practice in public health: piloting newly developed criteria.
Authors: Vinko Matej , Lesnik Tina , Krnel Sandra Radoš 
Published: May 2023

Abstract
Background
The Slovenian “Criteria for assessing public health interventions for the purpose of identifying and selecting good practices” is a tool designed to identify and select good practices in public health. Public health professionals used the criteria to evaluate interventions and assign scores based on three levels: Exclusion, Core, and Additional Criteria. The assessment took place from 2021 to 2022. The individual scores were compiled and a panel discussion was held to reach a final score. The interrater agreement was measured using percent overall agreement and Fleiss’s kappa coefficient.
Results
The study aimed to test the consistency of the criteria, and despite being the first time the criteria were used, a moderate interrater agreement was achieved. The lowest agreement was observed for the effectiveness and efficiency sub-criteria group. Challenges identified with the scoring process were due to the descriptive 1 to 5 scale and the varying specificity of the criteria. The results showed that studying consistency between evaluators can highlight areas for improvement or adjustment in assessment criteria and enhance the quality of the assessment instrument.
Conclusions
This study aimed to evaluate the efficacy of the Slovenian “Criteria for assessing public health interventions for the purpose of identifying and selecting good practices”, which was found to offer valuable insights for various stakeholders. To enhance the quality of best practice assessments, the study suggests exploring opportunities for involving policy makers in the assessment process. Such collaboration between researchers, practitioners, and decision-makers can lead to significant improvements in the production and application of public health research.
Estimating program coverage in the treatment of acute malnutrition using population-based cluster survey methods: Results from surveys in five countries in the Horn, Sahel, and the African Great Lakes regions
Authors: Heymsfield Grace , Radin Elizabeth , Biotteau Marie , Kangas Suvi , Ndumi Assumpta , Tausanovitch Zachary , Tesfai Casie , Kiema Léonard , OUEDRAOGO Wenldasida Thomas , Mamoudou Badou Seni , Issa Mahamat Garba , Bangali Lievin , Ngboloko Marie Christine Atende Wa , Chaïbou Balki , Maman Maman Bachirou , Mahdi Mukhtar Sirat , Mohamud Farhan Momahed , Leidman Eva , Bilukha Oleg 
Published: May 2023

Abstract

Background Despite their utility for program planning, acute malnutrition treatment coverage estimates at the national and sub-national levels are rarely available. Prior work has identified methodological concerns with current approaches.Methods We estimated the point prevalence and treatment coverage of acute malnutrition in 14 districts (or similar subnational areas) across 5 high-burden countries in Africa using representative cluster-based population survey methods, and compared these estimates to those derived from administrative data and other direct methods where available. We also aimed to assess information about risk factors for malnourished children by coverage status.Results The point estimate of coverage suggests that < 20% of eligible children with severe acute malnutrition (SAM) were enrolled in treatment in eleven administrative areas. We found that in some contexts, coverage estimates derived using administrative data are useful, while in others, they are not – and that their accuracy can vary by month and year. By comparison, coverage estimates from other direct methods were overestimated and/or outdated, and practitioners tended to overestimate coverage. Coverage did not differ significantly by sex or age of the child but did vary by mid-upper arm circumference (MUAC) at assessment. Measured SAM coverage did not correlate either with measured SAM prevalence or with expected coverage estimated a priori by program staff.Conclusions Our findings suggest that in the assessed high-burden countries, many more children are eligible for treatment than are enrolled. We present this methodology as an alternative to existing primary methods and a complement to coverage estimates from routine program and population data.
Mass photometry: A powerful tool for carbohydrates-proteins conjugation monitoring and glycoconjugates molecular mass determination
Authors: Wu Di , Xu Peng , Kelly Meagan , Ryan Edward T. , Kováč Pavol , Piszczek Grzegorz 
Published: May 2023

Abstract
Glycoconjugate vaccines are important additions to the existing means for prevention of diseases caused by bacterial and viral pathogens. Conjugating carbohydrates to proteins is a crucial step in the development of these vaccines. Traditional mass spectrometry techniques, such as MALDI-TOF and SELDI-TOF, have limitations in detecting glycoconjugates with high molecular masses. Mass photometry (MP) is a single-molecule technique that has been recently developed, which allows mass measurements of individual molecules and generates mass distributions based on hundreds to thousands of these measurements. In this study, we evaluated the performance of MP in monitoring carbohydrate-protein conjugation reactions and characterization of conjugates. Three different glycoconjugates were prepared from carrier protein BSA, and one from a large protein complex, a virus capsid with 3.74 MDa molecular mass. The masses measured by MP were consistent with those obtained by SELDI-TOF-MS and SEC-MALS. The conjugation of BSA dimer to carbohydrate antigen was also successfully characterized. This study shows that the MP technique is a promising alternative to methods developed earlier for monitoring glycoconjugation reactions and characterization of glycoconjugates. It measures intact molecules in solution and it is highly accurate over a wide mass range. MP requires only a very small amount of sample and has no specific buffer constraints. Other MP advantages include minimal cost of consumables and rapid data collection and analysis. Its advantages over other methods make it a valuable tool for researchers in the glycoconjugation field.
The bidirectional regulation mechanism of NMMO concentration change on cellulose dissolution and regeneration
Authors: Deng Zikang , Zhou Guohui , Fang Timing , Fang Kuanjun , Liu Xiaomin 
Published: May 2023

Abstract
The dissolution and regeneration process of cellulose molecules in NMMO aqueous solution was studied by molecular dynamics (MD) simulation.
The effect of the concentration of NMMO aqueous solution on the structure of cellulose was discussed. During the simulation process, the aggregation structure of cellulose molecules changed significantly, and experienced the dissolution process and regeneration process. During the dissolution of cellulose, the NMMO aqueous solution penetrates into the cellulose bundle from the cellulose O2-H2-O6 direction. NMMO around O6, O3 and O2 plays a vital role in the dissolution of cellulose. NMMO destroys the hydrogen bonds between the intra-chains of cellulose, thus making cellulose dissolved in the solvent. During the regeneration process, the concentration of NMMO aqueous solution decreased, and water molecules around the acetal oxygen atom increased, which destroyed the hydrogen bond between NMMO and cellulose, and made the cellulose single chain form aggregates. Although it eventually aggregated into cellulose bunches structure, the hydrogen bond of regenerated cellulose lacked regularity, which affected the stability of the regenerated cellulose structure.
The importance of social oocyte cryopreservation in supporting local municipalities
Authors: Ohno Motoharu , Kikuchi Iwaho , Kagawa Noriko , Shinozaki Ikumi , Shirosaki Yuka , Ichiyama Takuhiko , Makino Shintaro , Yoshida Koyo 
Published: May 2023

Abstract
Purpose To examine the impact of social oocyte cryopreservation on local communities.Methods A prospective study was conducted on city-dwelling women < 35 years old attending monthly seminars on oocyte retrieval/cryopreservation to whom the study concept was explained. Egg collection and storage management costs were free for three years after the project completed, and subsequent actual storage costs were borne by the individuals. After oocyte retrieval, we conducted a questionnaire on oocyte cryopreservation and administrative assistance.Results Of the 62 seminar participants, 2 became pregnant naturally without oocyte retrieval. Oocytes were retrieved in 34 women (average age: 32.8 years, number of oocytes obtained: 8.3), among whom four subsequently became pregnant and gave birth through natural pregnancy or artificial insemination, and one became pregnant and gave birth using frozen oocytes. In a follow-up questionnaire of 34 subjects, all responded that they were glad to have oocyte cryopreservation, but 23 subjects (67.6%) answered that they could not perform cryopreservation without financial assistance. Twenty-five patients (73.5%) wanted to try to conceive without using frozen oocytes as a post-cryopreservation plan.Conclusions Egg cryopreservation and associated workshops may be useful not as a countermeasure against the declining birthrate but for the expansion of women’s reproductive options.
A follow-up study on factors affecting the rehabilitation of patients with hypothyroidism in different selenium environments
Authors: Wang Si , Chen Ping , He Yayi , Wei Jing , Tian Li , Wu Yajun , Lv Hongjun , Peng Xiaogang , Zhang Xingru , Shi Bingyin , Wu Qian 
Published: May 2023

Abstract
Background Hypothyroidism is a key manifestation of autoimmune thyroid disease (AITD). Our previous research has found that low selenium (Se) status was linked to an elevated prevalence and incidence of thyroid diseases. We hypothesized that Se status may also influence the restoration of thyroid function. Thus, our study aims to investigate the factors affecting the recovery of thyroid function in patients with (sub-)clinical hypothyroidism, with a specific focus on Se status.Methods We conducted a 6-year prospective cohort study comparing different Se concentration regions. Demographic and disease data were collected from 1190 subjects (549 Se-adequate and 641 Se-deficient), who successfully completed the follow-up study in 2019. Additionally, urinary iodine (I) levels, thyroid function, and serum and nail Se levels were measured. We used logistic regression to investigate the relationship between Se deficiency and thyroid function recovery.Results Two counties were similar in sex, smoking status. The recovery rate of thyroid function was significantly higher in Se-deficient counties (46.0% vs. 30.6%, P = 0.008). In multivariate analysis, our results show that female sex [OR (95%CI) = 1.977 (1.279–3.055), P = 0.002] and increasing age [OR (95%CI) = 1.027 (1.007–1.047), P = 0.007] were associated with the recovery rate. Additionally, our study revealed that while the Se status was significant in univariate analysis, this association appeared to fade in multivariate analysis.Conclusions Female sex and increasing age have unfavorable effects on the recovery of thyroid function in patients with (sub-)clinical hypothyroidism who are over 30 years old.
The triglyceride-glucose index is a predictor for cardiovascular and all-cause mortality in CVD patients with diabetes or pre-diabetes: results from the NHANES database prospective cohort study
Authors: Zhang Qin , Jiao Xiaojuan , Shen Yunfeng 
Published: May 2023

Abstract
Background: The association between the triglyceride-glucose (TyG) index and mortality in cardiovascular disease (CVD) patients with diabetes or pre-diabetes remains unclear. Therefore, the aim of this study was to explore the relationship between baseline TyG index and all-cause and cardiovascular (CV) mortality among American adults with CVD who have diabetes or pre-diabetes.
Methods: This study enrolled 1072 American adults with cardiovascular disease (CVD) and either diabetes or pre-diabetes, who participated in the National Health and Nutrition Examination Survey (2001-2018). Mortality outcomes were determined by linking to National Death Index (NDI) records up to December 31, 2019. The relationship between baseline TyG index and mortality in these patients was analyzed using Cox proportional hazards model and two-piecewise Cox proportional hazards model to explore potential nonlinear associations.
Results:During 7541 person-years of follow-up, a total of 334 all-cause deaths and 112 CVD-related deaths were recorded. The two-piecewise linear regression analysis revealed a U-shaped association between the baseline TyG index and all-cause and CVD mortality in CVD patients with diabetes or pre-diabetes. Specifically, a baseline TyG index lower than the threshold values (TyG index < 9.07 in all-cause mortality and < 8.92 in CVD mortality) was found to be negatively associated with mortality, with a hazard ratio (HR) of 0.48 (95% CI=0.28-0.83) for all-cause mortality and 0.43 (95% CI=0.08-1.41) for CVD mortality. In contrast, a baseline TyG index higher than the threshold values (TyG index > 9.07 in all-cause mortality and > 8.92 in CVD mortality) was positively associated with mortality, with a HR of 1.41 (95% CI=1.01-1.97) for all-cause mortality and 2.12 (95% CI=1.36-3.32) for CVD mortality.
Conclusions: A U-shaped association was observed between the baseline TyG index with CVD and all-cause mortality in CVD patients with diabetes or pre-diabetes in a American population. The thresholds of 8.92 and 9.07 for CVD and all-cause mortality, respectively.
Systematic evaluation and meta-analysis of the effectiveness of Chinese patent medicines in combination with western medicines in the treatment of irritable bowel syndrome
Authors: guo Yajing , Li Ting , Lu Qiongqiong , He Yuxi , Wu Yue , Yang Xiaojun 
Published: May 2023

Abstract
Aim A meta-analysis was used to evaluate the effectiveness of Chinese patent medicines in combination with western medicines in the treatment of irritable bowel syndrome.Methods CNKI, Wanfang Academic Journal Full Text Database, VIP, Pubmed, Embase, Web of science, Cochrane Library databases were searched for clinical studies on the treatment of irritable bowel syndrome with Chinese patent medicines published from the date of establishment to March 15, 2023, and the data were strictly screened and tthe data were extracted and evaluated, and the data were analysed and collated using RevMan 5.4 and stata16 software.Results The final 21 RCTs, including 14 proprietary Chinese medicines, all orally administered, were included in a total of 2007 patients. The results of the Meta-analysis showed that the combination of Chinese patent medicines with Western medicines improved the overall clinical effectiveness (OR = 3.81, 95% CI [2.84–5.12], P < 0.00001); significantly improved abdominal pain scores (MD=- 0.66, 95% CI [-0.93, -0.40], P < 0.00001); improved stool trait scores (MD = -0.48, 95% CI [-0.59, -0.37], P < 0.00001); improved IBS-SSS scores (MD = -44.36, 95% CI [-53.64, -35.08], P < 0.00001); improved IBS-QOL positive (MD = 10.27, 95% CI [3.50, 17.04], P = 0.003 < 0.05) and negative scores (MD=-7.91, 95% CI [-15.62, -0.02], P = 0.04 < 0.05); improved HAMA scores (MD=-3.37, 95% CI [-6.49, -0.24], P = 0.03); but no statistical difference in improving HAMD scores (MD=-2.83, 95% CI [-5.74,0.08], P = 0.06 > 0.05).Conclusion: Chinese patent medicine combined with western medicine is more effective than single western medicine in the treatment of different types of irritable bowel syndrome.
Unsupervised brain MRI image registration based on 3D hybrid ViT and convolutional U-net
Authors: Wang Junyao , Liu Feng , Shu Shi , Tao Guowei , Zhou Fu 
Published: May 2023

Abstract
During a patient's disease progression, MRIs scaned in different times need to be registered before and after. However, the location and structure of tissue inside the human body may change with the growth of illnesses, interfering with the physician's ability to quickly diagnose the progression of the disease. To reach this goal, we proposed a 3D hybrid ViT and convolutional U-net for brain MRI image registration, which achieved a higher dice score than ViT-V-Net and VoxelMorph. In the meantime, we have had an idea of a novel loss function for gray image registration called grad-loss, which concentrates on the difference and gradient at each voxel of the MRI image. Quantitative and qualitative comparison results demonstrate that our model outperforms the previous ViT-based and convolution-based networks and achieved a better dice score of 79.7% in OASIS dataset.
Low-Dose Brain Radiation: Lowering hyperphosphorylated-Tau without Increasing DNA Damage or Oncogenic Activation
Authors: Iacono Diego , Murphy Erin , Stimpson Cheryl , Perl Daniel , Day Regina 
Published: May 2023

Abstract
Brain radiation has been medically used to alter the metabolism of cancerous cells and induce their elimination. Rarely, though, brain radiation has been used to interfere with the pathomechanisms of non-cancerous brain disorders, especially neurodegenerative disorders.
Data from low-dose radiation (LDR) on swine brains demonstrated reduced levels of phosphorylated-tau (CP13) and amyloid precursor protein (APP) in radiated (RAD) vs. sham (SH) animals. Phosphorylated-tau and APP are involved in Alzheimer’s disease (AD) pathogenesis.
We determined if the expression levels of hyperphosphorylated-tau, 3R-tau, 4R-tau, synaptic, intraneuronal damage, and DNA damage/oncogenic activation markers were altered in RAD vs. SH swine brains.
Quantitative analyses demonstrated reduced levels of AT8 and 3R-tau in hippocampus (H) and striatum (Str), increased levels of synaptophysin and PSD-95 in frontal cortex (FCtx), and reduced levels of NF-L in cerebellum (CRB) of RAD vs. SH swine. DNA damage and oncogene activation marker levels did not differ between RAD and SH animals, except for histone-H3 (increased in FCtx and CRB, decreased in Str), and p53 (reduced in FCtx, Str, H and CRB).
These findings confirm the region-based effects of sLDR on proteins normally expressed in larger mammalian brains and support the potential applicability of LDR to beneficially interfere against neurodegenerative mechanisms.
Exploring the molecular mechanism of Licorice rose beverage anti-melasma based on network pharmacology, molecular docking technology and in vivo and in vitro experimental verification
Authors: Zhai Dan , Hu Yi , Liu Li , Wang Zhuxian , Liang Peiyi , Jiang CuiPing , Li Hui , Zeng Quanfu , Chen Hongkai , Wu Yufan , Guo Yinglin , Yi Yankui , Shen Chunyan , Zhu Hongxia , Liu Qiang 
Published: May 2023

Abstract
Melasma is a pigmentation disease with refractory and high recurrence risk. Therefore, finding effective treatment has become the focus of research. The aim of this study was to reveal the mechanism of Licorice rose beverage (LRB) in treating melasma from the perspective of network pharmacology and in vitro and in vivo experimental techniques. Network pharmacological studies have shown that Isolicoflavonol, quercetin, kaempferol are the main active components of anti-melasma and TYR is the main target. Molecular docking studies have shown that these compounds have a good affinity for these targets. In vitro tyrosinase inhibition experiments showed that LRB could significantly inhibit tyrosinase activity. In vivo studies showed that LRB could significantly improve skin damage and skin pigmentation, reduce the activities of serum and skin tyrosinase in model mice, increase the activity of SOD in serum, and reduce the content of MDA in mice, showing a good effect of anti-melasma. In conclusion, these findings reveal the molecular mechanism of LRB in treating melasma and provided the scientific basis for this product's development and clinical application.
The technique of arsenic elimination from contaminated soil with enhanced conditions by electro-kinetic remediation
Authors: Hawal Laith Hamdan , Al-Sulttani Ali Omran 
Published: May 2023

Abstract
Remediation of arsenic-contaminated soil by the technique of electro-kinetic using various enhanced conditions is the thrust of this study. Many tests were performed with different operating conditions such as the electrodes solution (tap water) with a variable pH at (2, 5, and 8). Cyclodextrin (10% hydroxypropyl-beta-cyclodextrin or HPCD) has been used as an activating agent that helps enhance this process of soil arsenic clean-up. Agricultural wastes (pomegranate peels) were used after treating them as an adsorbent to impede the return of pollutants to the soil as a result of reverse osmosis. The obtained results after the remediation completion indicated that the best elimination capacity was 72% at a pH of 2. This indicates that the elimination capacity increases with decreasing pH of the electrodes solution. Mixing the HPCD solution with soil as an enhanced solution increased the solubility and desorption of arsenic from the soil. Then, arsenic-containing HPCD micelles readily moved to the cathode electrode by electro osmotic flow, and the elimination capacity increased (84%). It was concluded that pomegranate peels are a good adsorbent for arsenic returning to the soil during the treatment process as a result of reverse osmosis. Hence, the application of this material in this research gave a perfect impression of its use as an inexpensive, environmentally friendly adsorbent and an alternative to commercial absorbents.