bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unveiling the Critical Role of Ion Coordination Configuration of Ether Electrolytes for High Voltage Lithium Metal Batteries
Authors: Chen Shunqiang , Fan JiaJia , Cui Zhuangzhuang , Tan Lijiang , Ruan Digen , Zhao Xin , Jiang Jinyu , Jiao Shuhong , Ren Xiaodi 
Published: April 2023

AbstractAlbeit ethers are favorable electrolyte solvents for lithium (Li) metal anode, their inferior oxidation stability (<4.0 V vs. Li/Li+) is problematic for high‐voltage cathodes. Studies of ether electrolytes have been focusing on the archetype glyme structure with ethylene oxide moieties. Herein, we unveil the crucial effect of ion coordination configuration on oxidation stability by varying the ether backbone structure. The designed 1,3‐dimethoxypropane (DMP, C3) forms a unique six‐membered chelating complex with Li+, whose stronger solvating ability suppresses oxidation side reactions. In addition, the favored hydrogen transfer reaction between C3 and anion induces a dramatic enrichment of LiF (a total atomic ratio of 76.7 %) on the cathode surface. As a result, the C3‐based electrolyte enables greatly improved cycling of nickel‐rich cathodes under 4.7 V. This study offers fundamental insights into rational electrolyte design for developing high‐energy‐density batteries.
Tuning the Electronic Properties of Platinum in Hybrid‐Nanoparticle Assemblies for use in Hydrogen Evolution Reaction
Authors: Yang Ling , Grzeschik Roland , Jiang Ping , Yu Linfeng , Hu Cejun , Du Aoxuan , Schlücker Sebastian , Xie Wei 
Published: April 2023

AbstractPlatinum is the best electrocatalyst for the hydrogen evolution reaction (HER). Here, we demonstrate that by contact electrification of Pt nanoparticle satellites on a gold or silver core, the Fermi level of Pt can be tuned. The electronic properties of Pt in such hybrid nanocatalysts were experimentally characterized by X‐ray photoelectron spectroscopy (XPS) and surface‐enhanced Raman scattering (SERS) with the probe molecule 2,6‐dimethyl phenyl isocyanide (2,6‐DMPI). Our experimental findings are corroborated by a hybridization model and density functional theory (DFT) calculations. Finally, we demonstrate that tuning of the Fermi level of Pt results in reduced or increased overpotentials in water splitting.
Utilizing Cationic Vacancies and Spontaneous Polarization on Cathode to Enhance Zinc‐Ion Storage and Inhibit Dendrite Growth in Zinc‐Ion Batteries
Authors: Bai Liqi , Hu Zihan , Hu Cheng , Zhang Songge , Ying Yiran , Zhang Yingge , Li Lu , Zhang Hanfang , Li Nan , Shi Shanshan , Liu Shuo , Hao Lin , Liu Tongyao , Huang Hongwei , Huang Haitao , Zhang Yihe 
Published: April 2023

AbstractHigh energy density and intrinsic safety are the central pursuits in developing rechargeable Zinc‐ion batteries (ZIBs). The capacity and stability of nickel cobalt oxide (NCO) cathode are unsatisfactory because of its semiconductor character. Herein, we propose a built‐in electric field (BEF) approach by synergizing cationic vacancies and ferroelectric spontaneous polarization on cathode side to facilitate electron adsorption and suppress zinc dendrite growth on the anode side. Concretely, NCO with cationic vacancies was constructed to expand lattice spacing for enhanced zinc‐ion storage. Heterojunction with BEF leads to the Heterojunction//Zn cell exhibiting a capacity of 170.3 mAh g−1 at 400 mA g−1 and delivering a competitive capacity retention of 83.3 % over 3000 cycles at 2 A g−1. We conclude the role of spontaneous polarization in suppressing zinc dendrite growth dynamics, which is conducive to developing high‐capacity and high‐safety batteries via tailoring defective materials with ferroelectric polarization on the cathode.
Dual Photochemical H‐Atom Transfer and Cobalt Catalysis for the Desaturative Synthesis of Phenols from Cyclohexanones
Authors: Caldora Henry P. , Zhang Zhenhua , Tilby Michael J. , Turner Oliver , Leonori Daniele 
Published: April 2023

AbstractPhenols are integral aromatic molecules widely encountered in the structure of natural products and routinely utilised for the synthesis of high‐value materials. Accessing highly substituted derivatives can often be difficult, especially when their functionalization pattern does not match the intrinsic reactivity leveraged by electrophilic aromatic substitution (SEAr) chemistry. Here, we provide an alternative and mechanistically distinct approach for phenol synthesis using saturated cyclohexanone precursors. This process operates at ambient temperature, under simple purple light irradiation, and features a dual catalytic manifold carrying four sequential H‐atom transfer processes.
Design of Multicomponent Peptide Fibrils with Ordered and Programmable Compositional Patterns
Authors: Cheng Dan , Chen Xin , Zhang Weijia , Guo Pan , Xue Wenhui , Xia Junfan , Wu Siyu , Shi Junhui , Ma Dan , Zuo Xiaobing , Jiang Bin , Li Shaowei , Xia Ningshao , Jiang Yunbao , Conticello Vincent P. , Jiang Tao 
Published: April 2023

AbstractAdvanced applications of biomacromolecular assemblies require a stringent degree of control over molecular arrangement, which is a challenge to current synthetic methods. Here we used a neighbor‐controlled patterning strategy to build multicomponent peptide fibrils with an unprecedented capacity to manipulate local composition and peptide positions. Eight peptides were designed to have regulable nearest neighbors upon co‐assembly, which, by simulation, afforded 412 different patterns within fibrils, with varied compositions and/or peptide positions. The fibrils with six prescribed patterns were experimentally constructed with high accuracy. The controlled patterning also applies to functionalities appended to the peptides, as exemplified by arranging carbohydrate ligands at nanoscale precision for protein recognition. This study offers a route to molecular editing of inner structures of peptide assemblies, prefiguring the uniqueness and richness of patterning‐based material design.
Modification of ZSM‐5 zeolite nanoparticles by graphene oxide to improve anticorrosion properties of polyurethane coating
Authors: Darabinajand Bahman , Mirmohseni Abdolreza , Niaei Aligholi 
Published: April 2023

AbstractPolyurethane coatings are a good option for the protection of various structures due to their unique properties. In order to improve their barrier performance against corrosive species, various nanoparticles have been embedded into polymer coating. In this project, the ZSM‐5 zeolite nanoparticles are modified with graphene oxide. Field emission scanning electron microscopy and Fourier transform infrared spectroscopy are used for characterizing unmodified and GO‐modified ZSM‐5 zeolites. The effect of ZSM‐5 zeolite and ZSM‐5 zeolite modified with GO addition on the anticorrosion properties of polyurethane (PU) coating is evaluated by electrochemical impedance spectroscopy, Tafel polarization, and Pull‐off tests. Modification of ZSM‐5 zeolite with GO has greatly influenced the anticorrosion properties of zeolite nanoparticles in polyurethane coatings. Among various PU coatings, the PU/ZSM‐5‐GO coating on mild steel shows the best protective properties (highest Rct and lowest icorr) against active corrosive species.
Impact of cost of solid biofuels on the viability of their application to generate process heat in Mexico: a case study
Authors: Durán M. D. , Jiménez J. , García M. , Mora E. G. , Weber B. 
Published: April 2023

AbstractThis study determines the cost of producing different biofuels such as wood chips and pellets. It evaluates the factors that determine the cost of solid biofuels (SBFs), such as raw material, location, and transportation cost. The analysis is carried out with two different raw materials, sawdust, forest residue and pruning, and takes into account three different locations: Durango, State of Mexico, and Jalisco. The production cost in USD per GJ is determined. This cost is compared with the cost of generating the same amount of energy using fuel oil to evaluate the circumstances under which the application of solid biofuel would be feasible. An elementary CO2 emissions analysis of transportation has also been developed to compare these emissions with those of the fuel oil currently used to evaluate the feasibility from an environmental point of view. Transportation largely determines the cost of production and the feasibility of applying solid biofuel. Some indications about the maximum distances that the SBF can be transported to its final use are provided. © 2023 Society of Industrial Chemistry and John Wiley & Sons Ltd.
Leicht bauen mit Beton – ausgewählte Forschungsarbeiten des ILEK – Teil 2: Strukturleichtbau
Authors: Blandini Lucio , Kovaleva Daria , Haufe Carl Niklas , Nething Christoph , Nigl David , Nitzlader Markus , Smirnova Maiia , Strahm Benedikt , Bosch Matthias , Funaro Daniele , Nistler Maximilian 
Published: April 2023

AbstractSeit mehr als 20 Jahren setzt sich das Institut für Leichtbau Entwerfen und Konstruieren in interdisziplinären Forschungsvorhaben mit dem vermeintlichen Paradoxon „Leicht bauen mit Beton“ auseinander. In einem zweiteiligen Beitrag werden nun Auszüge aus der aktuellen Forschung hierzu vorgestellt. Während im ersten Teil dieses Aufsatzes der Fokus auf den Materialleichtbau gelegt wird, behandelt der zweite Teil den Strukturleichtbau mit dem Schwerpunkt auf Entwurfs‐ und Herstellungsansätzen für ressourceneffiziente, nachhaltige Betonstrukturen. Dazu zählen insbesondere neuere Untersuchungen zum Tragverhalten und zur Vorspannung von Bauteilen aus Gradientenbeton. Neben der Minimierung des Bauteilgewichts wird auch aufgezeigt, wie der ökologische Fußabdruck durch wiederverwendbare Betonsegmente weiter reduziert werden kann. Ansätze zur abfallfreien Herstellung von ressourcenschonenden filigranen Komponenten mittels additiver Fertigungsverfahren werden am Beispiel von 3D‐gedruckten Sandschalungen und Biobeton aufgezeigt. Über den klassischen Leichtbau hinaus werden abschließend Potenziale für weitere Materialeinsparungen durch adaptive Betonbauteile vorgestellt.
Monte Carlo sensitivity analysis for unmeasured confounding in dynamic treatment regimes
Authors: Rose Eric J. , Moodie Erica E. M. , Shortreed Susan M. 
Published: April 2023

AbstractData‐driven methods for personalizing treatment assignment have garnered much attention from clinicians and researchers. Dynamic treatment regimes formalize this through a sequence of decision rules that map individual patient characteristics to a recommended treatment. Observational studies are commonly used for estimating dynamic treatment regimes due to the potentially prohibitive costs of conducting sequential multiple assignment randomized trials. However, estimating a dynamic treatment regime from observational data can lead to bias in the estimated regime due to unmeasured confounding. Sensitivity analyses are useful for assessing how robust the conclusions of the study are to a potential unmeasured confounder. A Monte Carlo sensitivity analysis is a probabilistic approach that involves positing and sampling from distributions for the parameters governing the bias. We propose a method for performing a Monte Carlo sensitivity analysis of the bias due to unmeasured confounding in the estimation of dynamic treatment regimes. We demonstrate the performance of the proposed procedure with a simulation study and apply it to an observational study examining tailoring the use of antidepressant medication for reducing symptoms of depression using data from Kaiser Permanente Washington.
The impact of a story on learning ketone body metabolism
Authors: Romero‐Zambrano Génesis , Valdivieso‐Rivera Fernando , Almeida José Rafael 
Published: April 2023

AbstractBiochemistry is a core subject in the cross‐disciplinary training on Biotechnology engineering courses. Metabolic pathways teaching has traditionally integrated hands‐on laboratory experiences and traditional lectures, which detail a large number of reactions at a molecular level, their enzymes and regulation. The current scenario of Covid‐19 outbreak have motivated the development of complementary tools that expand the horizon of metabolism teaching. In this study, we employed a story‐based methodology to strengthen the metabolic pathways learning and to measure students' perception. Specifically, a peer‐reviewed tale describing the ketone body metabolism was used during five semesters as a didactic strategy to teach this biochemical process. A questionnaire assessed the students' understanding and acceptance of the methodology (n = 83). Our findings showed that a high proportion of students (83.13%) were able to relate the story to the topics studied in the classroom (ketogenesis and ketolysis). On the other hand, they were satisfied and suggested that such methodology is effective and fun. In summary, most of the survey responses related to acceptance of story‐based strategy ranged from 72% to 97%. Collectively, these results indicated that the story is appropriate to decomplex pathways, becoming a simple tool for driving motivation, learning and engagement of students. The narrative represents a bridge to connect the intriguing series of chemical reactions involved in the anabolism and degradation of 3‐hydroxybutyrate (3‐OHB), acetoacetate, and acetone with previously learned knowledge, emotions, and key concepts. In conclusion, the tale was useful to decode ketone body‐related pathways and making metabolism learning more interesting and easier.
Development of simultaneous quantitative analytical method for metabolites of hexosamine biosynthesis pathway in lung cancer cells using ultra‐high‐performance liquid chromatography‐tandem mass spectrometry
Authors: Seo Yerim , Chung Eun Kyoung , Jung Byung Hwa 
Published: April 2023

AbstractThe hexosamine biosynthesis pathway (HBP) is a glucose metabolism pathway that produces uridine diphosphate N‐acetyl glucosamine (UDP‐GlcNAc). Substantial changes in HBP, including elevated HBP flux and UDP‐GlcNAc levels, are associated with cancer pathogenesis. Particularly, cancer cells expressing oncogenic Kirsten rat sarcoma virus (KRAS) are highly dependent on HBP for growth and survival. To differentiate between HBP metabolites in KRAS wild‐type (WT) and mutant (MT) lung cancer cells, a simultaneous quantitative method for analyzing seven HPB metabolites was developed using ultra‐high‐performance liquid chromatography‐tandem mass spectrometry. A simple method without complicated preparation steps, such as derivatization or isotope labeling, was optimized for the simultaneous analysis of highly hydrophilic HBP metabolites, and the developed method was successfully verified. The intra‐ and inter‐day coefficients of variation were less than 15% for all HBP metabolites, and the recovery was 89.67–114.5%. All results of the validation list were in accordance with ICM M10 guidelines. Through this method, HBP metabolites in lung cancer cells were accurately quantified, and it was confirmed that all HBP metabolites were upregulated in KRAS MT cells compared with KRAS WT lung cancer cells. We expect that this will be a useful tool for metabolic research on cancer and for the development of new drugs for cancer treatment.
Alveolar rhabdomyosarcoma has superior response rates to vinorelbine compared to embryonal rhabdomyosarcoma in patients with relapsed/refractory disease: A meta‐analysis
Authors: Allen‐Rhoades Wendy , Lupo Philip J. , Scheurer Michael E. , Chi Yueh‐Yun , Kuttesch John F. , Venkatramani Rajkumar , Meyer William H. , Mascarenhas Leo 
Published: April 2023

AbstractBackgroundPatients with alveolar rhabdomyosarcoma (ARMS) have inferior outcomes compared to patients with embryonal rhabdomyosarcoma (ERMS) and more effective chemotherapy options are needed for these patients. Vinorelbine is a semisynthetic vinca alkaloid that has clinical activity in relapsed rhabdomyosarcoma (RMS) when used alone or in combination with cyclophosphamide.AimsThe goal of our study was to evaluate whether RMS histology subtype influences response rate to vinorelbine alone or in combination.Materials & MethodsFive Phase 2 trials that enrolled RMS patients were included in the meta‐analysis. Two studies evaluated vinorelbine alone, two studies evaluated vinorelbine in combination with low dose oral cyclophosphamide, and one study evaluated vinorelbine and intravenous cyclophosphamide in combination with temsirolimus or bevacizumab. All RMS patients had relapsed or refractory disease and had received at least one prior therapy. Response was reported according to RECIST1.1 and was defined as a complete or partial response. Response data was obtained from published results or from trial principal investigator. RMS NOS patients were grouped with ERMS patients for this analysis. Summary estimates comparing differences between ARMS and ERMS response rates were generated using a random‐effects model to account for heterogeneity among the studies.ResultsOne hundred fifty‐six enrolled patients evaluable for response were included in the meta‐analysis, 85 ARMS, 64 ERMS and 7 RMS‐NOS. The combined effect generated from the random‐effects model demonstrated a 41% increase (p = 0.001, 95% CI; 0.21–0.60) in response to vinorelbine as a single agent or in combination in patients with ARMS compared to patients with ERMS. There was no significant difference in the rate of progressive disease between patients with ARMS compared to ERMS (p = 0.1, 95%CI; −0.26–0.02).DiscussionVinorelbine is an active agent for the treatment of relapsed or refractory RMS and a meta‐analysis of Phase 2 studies shows that radiographic responses in patients with ARMS were significantly higher than ERMS or RMS‐NOS.ConclusionThese data support further investigation of vinorelbine in newly diagnosed patients with RMS particularly those with alveolar histology.
Cancer‐Specific health equity metrics in the United States of America: A scoping review
Authors: Starkweather Angela , Cohen Bevin , Gray Tamryn F. , Linder Lauri , Zanville Noah 
Published: April 2023

AbstractHealth disparities in cancer care persist, and in some cases are growing, despite decades of research aimed at achieving equal outcomes for all Americans. There is growing consensus that reducing disparities will require a shift from aiming to provide care that is equal, to aiming to provide care that is equitable. The current landscape of metrics and interventions that move beyond equality (i.e., care provided equally to all patients) and towards equity (i.e., care provided variably and justly such that patients achieve equal outcomes) have not been characterized. Thus, the aim of this scoping literature review was to identify cancer‐specific health equity metrics and interventions, and to explore current gaps in the field. Following PRISMA guidelines, PubMed, CINAHL, PsycInfo, and Scopus were searched for studies published in English between 2012 and 2022 that implemented a metric to identify or an intervention to address cancer care inequities in the United States. The search returned 36,724 unique articles, of which 40 articles (1%) included an intervention to advance health equity. Metrics included timeliness of screening and treatment, receipt of goal‐concordant care, and survival. The vast majority of articles were cross‐sectional or cohort studies that described health disparities using one or more outcome metrics. Gaps identified included research on receipt of guideline‐concordant care, interventions addressing multiple levels of structural and social determinants of health, inclusion of children and families, and patient‐reported outcomes or other sources of data that could help inform interventions to advance equity.
Incidence of pneumonitis following the use of different anaplastic lymphoma kinase tyrosine kinase inhibitor regimens: An updated systematic review and meta‐analysis
Authors: Qie Wenting , Zhao Qian , Yang Linlin , Zou Bing , Duan Yanan , Yao YueYuan , Wang Linlin 
Published: April 2023

AbstractObjectivesAnaplastic lymphoma kinase tyrosine kinase inhibitors (ALK TKIs) have shown remarkable clinical activity in patients with non‐small‐cell lung cancer (NSCLC). However, pneumonitis is a serious side effect of ALK TKIs in NSCLC patients. In this meta‐analysis, we aimed to determine the incidence of ALK‐TKI‐associated pneumonitis.Materials and MethodsWe searched electronic databases to identify relevant studies published until August 2022. The incidence of pneumonitis was calculated using a fixed‐effects model when no substantial heterogeneity was observed. Otherwise, a random‐effects model was used. Subgroup analyses of different treatment groups were performed. Statistical analyses were conducted using STATA 17.0.ResultsTwenty‐six clinical trials involving 4752 patients were eligible for analysis. All‐grade pneumonitis incidence was 2.92% (95% confidence interval [CI]: 1.79%–4.27%), high‐grade (Grade 3–4) pneumonitis incidence was 1.42% (95% CI: 0.84%–2.12%) and Grade 5 pneumonitis incidence was 0.09% (95% CI: 0.00%–0.28%). The subgroup analysis showed that brigatinib was associated with the highest incidence of both all‐grade and high‐grade pneumonitis (7.09% and 3.06%, respectively). ALK TKI treatment after chemotherapy was associated with a higher incidence of all‐grade and high‐grade pneumonitis than first‐line ALK TKI treatment (7.73% vs. 2.26% and 3.64% vs. 1.26%, respectively). Cohorts from Japanese trials had a higher incidence of all‐grade and high‐grade pneumonitis.ConclusionOur study provides precise data on the incidence of pneumonitis in patients receiving treatment with ALK TKIs. Overall, ALK TKIs have tolerable pulmonary toxicity. Early pneumonitis identification and treatment are required to prevent further deterioration in patients receiving treatment with brigatinib and in those who received prior chemotherapy, particularly in the Japanese population.
PCSK9 inhibitor attenuates atherosclerosis by regulating SNHG16/EZH2/TRAF5‐mediated VSMC proliferation, migration, and foam cell formation
Authors: Liu Yan , Zhao Yueyan , Feng Panyang , Jiang Haijie 
Published: April 2023

AbstractProprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor has been demonstrated to exert a great cardioprotection in cardiometabolic impairments, including atherosclerosis. However, its underlying mechanism remains not fully understood. This study focuses on uncovering the actions of PCSK9 inhibitor on the connection between atherosclerosis and vascular smooth muscle cell (VSMC) behaviors. qRT‐PCR was utilized to detect the expression of SNHG16. Proliferation and migration of VSMC were characterized by Cell Counting Kit‐8 and wound healing assays. The intracellular lipids and foam cell formation were assessed by Oil Red O staining, fluorescence image, and cholesterol quantification kit. Atherosclerosis in vivo was evaluated by imaging the atherosclerotic lesions, hematoxylin‐eosin staining, Oil Red O staining and Masson staining. The interaction between SNHG16 with EZH2 and histone H3 lysine 27 trimethylation (H3K27me3) were investigated by fluorescence in situ hybridization, RNA immunoprecipitation, and chromatin immunoprecipitation assays. A ApoE−/− mice model was used to validate the role of PCSK9 inhibitor and SNHG16 for atherosclerosis. The protective regulation of PCSK9 inhibitor was observed both in high‐fat diet (HFD)‐fed mice and oxidized low‐density lipoprotein (ox‐LDL)‐treated VSMC, as manifested in the decreased the atherosclerotic lesions in vivo, as well as the weakened cell proliferation, migration, and formation of foam cells in vitro. SNHG16 was identified to be a downstream effector of PCSK9 inhibitor‐mediated biological functions, of which knockdown also significantly ox‐LDL‐treated VSMC proliferation, migration, and foam cell formation abilities. SNHG16 epigenetically suppressed TRAF5 via recruiting EZH2. Silencing of TRAF5 abolished the protective effects of SNHG16 knockdown on the pathogenesis of atherosclerosis. Collectively, PCSK9 inhibitor attenuated atherosclerosis by regulating SNHG16/EZH2/TRAF5 axis to impair the proliferation, migration, and foam cell formation of VSMC.