bluuebunny/crossref_metadata_2025_split huggingface dataset:
Feasibility and safety of Stanford A aortic dissection complete endovascular repair system in a porcine model
Authors: Peng Yucheng , Lin Wenhui , Lou Deda , Luo Songyuan , Li Bo , Su Mingcheng , Liu Jitao , Tang Yue , Luo Jianfang 
Published: February 2023

Abstract
Background:Acute type A aortic dissection (ATAAD) is a catastrophic disease with high morbidity and mortality. Although open surgery is still the gold standard for the treatment of ATAAD, some patients, with advanced age and multiple comorbidities, can only receive medical management alone. Nowadays, thoracic aortic endovascular repair (TEVAR) provides a potential treatment option for the patient with ATAAD, but traditional stent grafts (SGs), which are not designed for the ATAAD, are inapplicable to the unique anatomy of the aortic arch. Therefore, we innovatively created the BRIDGE system (Chuangxin Medical, Shenzhen, China), a complete endovascular reconstruction system designed to treat ATAAD. This study aimed to evaluate the feasibility and safety of the novel Stanford A aortic dissection complete endovascular reconstruction system in a porcine model.
Method: The BRIDGE system consists of the type A stent system and the type C stent system. Between November 2020 and March 2021, three white swine were utilized in the study. The BRIDGE system was deployed via the transcatheter approach under angiographic guidance. The swine(n = 3) treated with our system were evaluated using angiography before sacrifice 1-month after implantation, which was followed by gross specimen evaluation and histological examination of harvested tissues.
Result: The acute procedure success rate was 100% (3/3). The immediate post-procedural angiography showed that both type A SGs and type C SGs were deployed in satisfactory locations, with patency of the supra-aortic trunk and no endoleak. The cumulative mortality of 30-day was 0% without any adverse events. No device migration or leakage was observed angiographically, before sacrifice. The gross observation confirmed a type A SG covered part of the entry of anonyma. Favorable endothelialization, no thrombogenesis, and slight inflammatory infiltration of the tissues around the device were confirmed by microscopic examinations in all pigs.
Conclusion: It was feasible and secure to use Stanford A aortic dissection complete endovascular reconstruction system to implement a transcatheter endovascular repair in a porcine model. With this novel system, treating acute type A aortic dissection may be more efficient and secure in human.
Humate increases nitrogen fertiliser efficiency and reduced N leaching
Authors: Espie Peter Ross 
Published: February 2023

AbstractOne of the world’s greatest challenges is achieving sustainable food security without environmental damage. The projected increase in world population and will require use of nitrogen fertilisers for food production although excess agricultural N is a major contributor to climate change and ecosystem degradation. Southern Humate is a low-cost natural organic biostimulant that can beneficially alter soil microbiome function and plant productivity. We present evidence from a 5-year field study showing that adding humate to urea, global the most widely used N fertiliser, significantly altered soil microbiome composition, increased grassland production by 13.1% and significantly decreasing topsoil N leaching by 61.4% compared with urea. The increase in N fertiliser efficiency and reduction in negative environmental impact could contribute towards development of ecologically sustainable agriculture.
Effect of Active and Passive Stretching on Symptoms in Stable COPD: A Systematic Review and Meta-Analysis
Authors: Tian Rujin , Qiao Zhengtong , Zhou Ziliang , Zhang Jiazhen , Sa Siyue , Liu Kai 
Published: February 2023

Abstract
Background:
Chronic obstructive pulmonary disease (COPD) is a chronic lung disease with high mortality and disability rate. It caused the progressive airflow obstruction along with the change of relevant soft tissue. Stretching could lengthen the shorten respiratory muscle and increase its flexibility.
Objectives:
To investigate the effectiveness of stretching on the COPD patients.
Methods:
The PRISMA guideline was used to perform the review. We searched on six online databases (Web of Science, PubMed, Embase, Cochrane Library, CNKI and Wanfang Database) from inception until March 2022. The quality of the studies was appraised by PEDro scale. The pooled effect sizes of exercise capability, lung function parameters, dyspnea, psychological status and quality of life were reported.
Result: Of 422 studies, 11 studies (424 participants) met the inclusion criteria. The overall effect size of the 6MWT showed statistical difference between stretching group and the control group (P<0.00001). Among the lung function parameters, only respiratory rate (RR) and expiratory time (Te) showed superior statistical effect. The data about the psychological state, dyspnea and quality of life were too scant to conclude.
Conclusion: Stretching seemed to have strong effectiveness on improving the exercise capacity, and the breathing temporal parameters could be changed through stretching.
The risk factors of developing acute acalculous cholecystitis concomitant with EBV hepatitis in pediatric population
Authors: Kong Khai-Lun , Chen I-Lun , Huang Fu-Chen 
Published: February 2023

Abstract
Background
Acute acalculous cholecystitis (AAC) is the most common form of acute cholecystitis in the pediatric population and some cases could have fatal complications. Epstein-Barr virus (EBV) is by far the most knowledgeable viral agent implicated in the pathogenesis of AAC in recent years. Thus, the risk factors in the development of AAC were favorably determined in the settings of EBV hepatitis.
Methods
Patients below 18 years of age, who had been admitted to Kaohsiung Chang Gung Memorial Hospital and were diagnosed with AAC concomitant with EBV hepatitis between January 2012 and March 2021, were retrospectively analyzed in our study. Our analyses comprised of risk factors including gestational age, age, gender, body weight, history of abdominal surgery, body temperature, duration of fever and hospitalization, clinical presentation, blood test parameters, sonographic findings, and medication.
Results
The results showed that the mean duration of fever, the presence of ascites, and increased atypical lymphocytes were statistically significant in patients with AAC, symbolizing a more severe disease burden as compared to those without AAC. The presence of ascites in sonographic findings and atypical lymphocytosis over 6.25% may be the two most significant predictive factors of developing AAC in children with EBV hepatitis.
Conclusions
Our study concluded that children with EBV-related AAC have presented with longer duration of fever, ascites, and atypical lymphocytosis over 6.25%. Further observation and close follow-ups may be suggested in high-risk children to prevent the occurrence of complications that require an emergent operation.
Elevated expression of CXCL3 in colon cancer promotes malignant behaviors of tumor cells in an ERK-dependent manner
Authors: Cheng Yao , Yang Xinyan , Liang Lichun , Xin Hua , Dong Xinyu , Li Weidong , Li Jie , Guo Xiaoli , Li Yue , Zhang Chunbin , Wang Weiqun 
Published: February 2023

Abstract
Background: CXCL3 is a member of CXC-type chemokine family that is identified as a major regulator in immune and inflammation responses. Recently, numerous evidence indicated that CXCL3 is broadly expressed in various human tumor types, and it is also known to play a critical role in mediating tumor development and progression. However, the expression profile of CXCL3 and the exact molecular mechanism behind the role of CXCL3 in colon adenocarcinoma (COAD) has not been fully elucidated.
Methods: The expression and clinical significance of CXCL3 mRNA and protein in the tissues from COAD patients were estimated using bioinformatics and immunohistochemistry assays. The expression and roles of exogenous administration or overexpression of CXCL3 in HT-29 and SW480 COAD cells were determined using ELISA, CCK-8 and Transwell assays. Mechanically, CXCL3-induced malignant behaviors were elucidated using western blotting assay and ERk1/2 inhibitor PD98059.
Results: TCGA-COAD data analysis revealed that CXCL3 mRNA is highly expressed and has high clinical diagnostic accuracy in COAD. Increased expression of CXCL3 mRNA was associated with patient’s clinical stage, race, gender, age, histological subtype, nodal mestastasis and TP53 mutation status. Similarly, immunohistochemistry assay also exhibited that CXCL3 protein in COAD tissues was significantly up-regulated. Gene expression associated assay implied that CXCL1 and CXCL2 were markedly correlated with CXCL3 in COAD. PPI analysis revealed that CCNB1, MAD2L1, H2AFZ and CXCL2 may be the important molecules involved in CXCL3-related tumor biology. GSEA analysis revealed that CXCL3 was mainly enriched in the cell cycle, DNA replication, NOD-like receptors, NOTCH and TGF-β Signal pathways. In vitro, exogenous administration or overexpression of CXCL3 resulted in increased malignant behaviors of HT-29 and SW480 cells, and overexpression of CXCL3 affected the expression of genes related to extracellular signal regulated kinase (ERK) pathway, including ERK1/2, p-ERK, Bcl-2, Bax and Cyclin D1. In addition, CXCL3-induced malignant behaviors in HT-29 and SW480 cells were obviously attenuated following treatment with ERK inhibitor PD98059.
Conclusion: CXCL3 is upregulated in COAD and plays a crucial role in the control of malignant behaviors of tumor cells, which indicated its involvement in the pathogenesis of COAD.
The value of heart rate variability in predicting long-term poorer outcome in patients undergoing coronary artery bypasses grafting and referring intensive care unit: a prospective cohort study
Authors: Mehrabanian Mohammad Javad , Firoozabadi Mehdi Dehghani , Nooralishahi Behrang , Mortazian Meysam , Kachoueian Naser 
Published: February 2023

Abstract
Background
Heart rate variability (HRV) plays an important role in predicting poor prognosis after acute myocardial infarction, but whether this parameter is able to predict long-term adverse outcomes following revascularization procedures is still not clear. We investigated the value of HRV in predicting post-procedural adverse outcome (mortality and major adverse cardiovascular event or MACE) in patients undergoing coronary artery bypass grafting (CABG) surgery and referred to intensive care unit.
Methods
This prospective cohort study was performed on 258 consecutive patients underwent elective isolated CABG. All patients required intensive care unit referring before discharge from the hospital. All patients were planned for a 3-week cardiac rehabilitation program with a 24-hour electrocardiogram Holter monitoring. HRV was analyzed by computer and over-read manually. Within a follow-up period ranged 1 to 3 years, the patients were asked by phone for long-term outcome including death and MACE (including myocardial infarction, reoperation, or brain stroke).
Results
overall, 4.3% of patients died due to cardiovascular events and 15.1% suffered from long-term MACE. Comparing HRV indicators between non-survived and survived subgroups showed significantly lower mean RR, lower mean SDNN, lower LF and lower HF in former group. However, the comparison of HRV between the subgroups with and without long-term MACE showed no difference in HRV indicators between the two groups. Using Cox proportional hazard analysis, lowering HRV (SDNN) could effectively predict long-term death in patients underwent CABG.
Conclusion
Lower postoperative HRV can effectively predict long-term death after CABG in patients admitted to intensive care unit.
WITHDRAWN: Clinical course and ophthalmologic findings in idiopathic intracranial hypertension and pregnancy: a retrospective cohort study
Authors: Knoche Theresia , Danyel Leon Alexander , Varlet Lisa Justine , Haffner Paula , Alzureiqi Mohammad Salim , Kowski Alexander , Gaus Verena 
Published: February 2023

Abstract
Background:
Idiopathic intracranial hypertension (IIH) has its highest prevalence among women of childbearing age. Therefore, it inevitably coincides with pregnancy. Because of physiological maternal changes during pregnancy and because of limited safety data on the available pharmaceuticals, concerns regarding a potential worsening of the disease during pregnancy arise. The literature background is limited to few retrospective studies. The aim of this study was to explore the impact of pregnancy on the visual outcome and on the management of pregnant women with IIH.
Methods
In this cohort study, IIH patients with documented pregnancies were retrospectively identified by medical database screening. The diagnosis of IIH was based on the revised Friedman criteria. Patient records were reviewed for IIH clinical features, treatment strategy and adherence to therapy. The visual acuity, visual field defects and the grade of papilledema at baseline and after pregnancy were compared. Complications over the course of pregnancy and during delivery were recorded.
Results
The database screening identified 16 IIH patients (26.8 ± 5.7 years, median = 27 years) with 19 documented pregnancies. The clinical presentation of IIH during pregnancy was similar to that of non-pregnant IIH patients with visual disturbances in 100% and headaches in 94.8% of patients. When comparing the overall visual acuity and the visual field mean deviation at baseline and at follow-up, no significant differences were found. The visual acuity at baseline in women who were diagnosed with IIH during pregnancy was significantly lower than in women who had been diagnosed with IIH prior to conception but improved at the time of follow-up. Papilledema grading improved after pregnancy. The adherence to therapy was low with 68.8% of patients discontinuing therapy.
Conclusions
Pregnancy did not lead to lasting visual impairment in our cohort of IIH patients, although many patients discontinued therapy during pregnancy. Further prospective studies are necessary to improve the medical care for IIH patients in pregnancy.
Transforming planning and policy making processes - working differently at the intersections of climate, equity, and decolonization challenges
Authors: Cole Lindsay , Low Maggie 
Published: February 2023

Abstract
Cities are facing increasing pressures to address complex challenges of climate change, equity, and reconciliation with Indigenous Peoples as intersecting issues, and innovation into planning and policy making processes is urgently needed to achieve this. It is no longer good enough to work on these challenges discreetly, or solely within the dominant, western colonial paradigm and practices of governance. There are ongoing harms being caused by climate work that does not embed justice, and there are missed opportunities for synergies across these domains as they have the same systemic root causes. Cities must adapt and transform the processes and practices of planning and policy making in order to work at these problematic roots. Drawing on an empirical study, this article describes how social innovation, systemic design, and decolonizing practices can shape a different approach to planning and policy making processes when working at the intersections of climate, equity, and decolonization.
Direct RNA sequencing coupled with adaptive sampling enriches RNAs of interest in the transcriptome
Authors: Wan Yue , Yang Lin , Wang Jia Xu , Tham Cheng-Yong , de Sessions Paola Florez , Cheng Anthony 
Published: February 2023

Abstract
Abundant cellular transcripts occupy most of the sequencing reads in the transcriptome, making it challenging to assay for low abundant transcripts. Here, we utilize the adaptive sampling function of Oxford Nanopore sequencing to selectively deplete and enrich RNAs of interest without biochemical manipulation before sequencing. Adaptive sampling performed on a pool of in vitro transcribed RNAs resulted in a 3.2-4.6-fold increase in transcripts of interest in the accept-read pool. Enriching and depleting different proportions of the candida albicans transcriptome also resulted in a 3-fold enrichment in the accepted-read pool and an 10% increase in the number of reads, with longer transcripts being more efficiently depleted. Depleting all currently annotated candida albicans transcripts revealed 26 new transcripts and isoforms, 17 of which are antisense to existing transcripts. Further improvements in the adaptive sampling of RNAs will allow the technology to be widely applied to study RNA(s) of interest in diverse transcriptomes.
Impact of Tobacco, Marijuana, and Alcohol use on Overall Survival in Recurrent Metastatic head and neck Cancer Patients Treated with Immune Checkpoint Inhibitors
Authors: Alsavaf Mohammad Bilal , Issa Majd , Klamer Brett G , Husain Marium , Dibs Khaled , Pan Xueliang , Grecula John C , Old Matthew O , Konieczkowski David , Mitchell Darrion L , Baliga Sujith , Carrau Ricardo L , Rocco James W , Bonomi Marcelo , Blakaj Dukagjin M. , Bhateja Priyanka 
Published: February 2023

Abstract
Background:
The response rates to immune checkpoint inhibitors (ICI) remain low (13-20%) in metastatic head and neck cancer patients and better understanding of factors predictive of response to these agents is urgently needed. Here we explore the impact of smoking status, marijuana use and alcohol on treatment outcomes in recurrent-metastatic (R/M) head and neck squamous cell carcinoma (HNSCC) treated with ICI.
Methods:
We performed a retrospective analysis of 201 R/M HNSCC patients treated with ICI between January 15th 2016 and April 9th 2020 at a single institution.

Results:
Gender: 154 male (77%), 47 female (23%). Median age 61 (IQR: 55-68). ICI drug: pembrolizumab 100 (50%), nivolumab 91 (45%), nivolumab+ipilimumab 10 (5%). Line of therapy: first: 98 (49%), second and beyond: 103 (51%). Tumor site: oropharynx 84 (42%), oral cavity 45 (22%), larynx 26 (13%), other sites 46 (23%). p16 tumor status: negative 132 (66%), positive 69 (34%). Smoking status: former 111 (55%), never 54 (27%), current 36 (18%), median pack-year 18 (IQR: 0-37). Alcohol use: yes 110 (55%), no 91 (54%). Marijuana use: yes 47 (23%), no 154 (77%). Overall response rate: 36 (18%). Median OS: 12 months (95% CI: 9.4-14.8). Tobacco: former (HR: 0.75, 95% CI: 0.50, 1.11), current (HR: 0.58, 95% CI: 0.33, 1.02). Marijuana: yes (HR: 0.93, 95% CI: 0.58, 1.49). Alcohol: yes (HR: 1.04, 95% CI: 0.72, 1.49).
Conclusion:
In our cohort, smoking status, marijuana use and alcohol consumption did not have a statistically significant impact on OS in patients with R/M HNSCC treated with ICI.
Trial registration: retrospectively registered.
Comparison of body composition in different dialysis states of end-stage renal disease and analysis of influencing factors
Authors: Li Yuxin , Sun Juan , Wu Hong , Liu Jun , Tang Shiqi , Ouyang Qin , Peng Xinyue , Wang Jianwen 
Published: February 2023

Abstract
Objective:To compare the differences in body composition in end-stage renal disease patients.
Methods:General data, biochemical data, and body composition indexes were collected to compare the differences in body composition indexes in ND, PD, and HD states. Spearman’s correlation and multiple linear stepwise regression analyses were performed to investigate the factors influencing the dependent variables.
Results: (1) Skeletal muscle index and phase angle were higher in the PD group than in the HD group (p < 0.05); total body water was lower in the PD and HD groups than in the CKD5-ND group (p < 0.05). (2) In the CKD5-ND and PD groups, the influencing factors of PHA were age, albumin, and prealbumin.
Conclusion: The patients with this central abdominal dialysis were better than those with HD in terms of nutrition and inflammation. PHA may be used to evaluate the nutritional status of patients with CKD5-ND and PD.
Age-associated risk of sarcopenia, falls and fractures: results of Ukrainian cohort study
Authors: Grygorieva Nataliia , Musiienko Anna , Bystrytska Maryna 
Published: February 2023

Abstract
Background
Nowadays, it is well-known that sarcopenia increases the risk of falls and fractures, and therefore, requires correction in order to improve the quality and duration of life of elderly people. Most of the early performed studies were conducted among community-dwelling subjects without stratification by ethnicity. This research aimed to study the age-related changes in the sarcopenia risk, falls, and fractures in Ukrainian women in the late reproductive and postmenopausal periods.
Materials and Methods
In the one-center cohort study we examined 573 females aged from 40 to 89 years old. For the analysis, the subjects were grouped by age decades and presence of high sarcopenia risk (HSR). The sarcopenia risk was measured by Strength, assistance with walking, rising from a chair, climbing stairs, and falls (SARC-F) questionnaire, the risk of falls using the Desmond Fall Risk Questionnaire, 10-year probability of major osteoporotic and hip fractures was assessed by Fracture Risk Assessment Tool, and daily activity – according to the Instrumental Activities of Daily Living scale. Also, we measured the hand grip strength and performed a five-repetition sit-to-stand test.
Results
The frequency of HSR increased with age from 1.5% in the 40-49-year-old group to 73.7% in the subjects over 80 years old, as well as fracture and fall risks (p ˂ 0.00001 for both indices) that were related to decreasing of independence in subjects everyday life. Also, we revealed age-dependent loss of muscle strength according to the hand grip and the five-repetition sit-to-stand test. After the adjustment of the subjects by age we found that the females with HSR had a higher risk of falls, a lower level of independence, and increased frequency and risk of osteoporotic fractures.
Conclusion
Women with HSR have a higher risk of falls, fractures, and more limitations in daily living activities independently from age and body mass index. These findings request comprehensive management of older women with attention to various parameters for the increase of independence and quality of life.