bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical Features, Genetic Findings, and Risk Stratification in Arrhythmogenic Right Ventricular Cardiomyopathy: Data From a Brazilian Cohort
Authors: Quintella Sangiorgi Olivetti Natália , Sacilotto Luciana , Wulkan Fanny , D’Arezzo Pessente Gabrielle , Lombardi Peres de Carvalho Mariana , Moleta Danilo , Tessariol Hachul Denise , Veronese Pedro , Hardy Carina , Pisani Cristiano , Wu Tan Chen , Vieira Marcelo Luiz Campos , de França Lucas Arraes , de Souza Freitas Matheus , Rochitte Carlos Eduardo , Bueno Sávia Christina , Bastos Lovisi Vitor , Krieger José Eduardo , Scanavacca Maurício , da Costa Pereira Alexandre , da Costa Darrieux Francisco 
Published: January 2023

Background:
Arrhythmogenic right ventricular cardiomyopathy (ARVC), a rare inherited disease, causes ventricular tachycardia, sudden cardiac death, and heart failure (HF). We investigated ARVC clinical features, genetic findings, natural history, and the occurrence of life-threatening arrhythmic events (LTAEs), HF death, or heart transplantation (HF-death/HTx) to identify risk factors.

Methods:
The clinical course of 111 consecutive patients with definite ARVC, predictors of LTAE, HF-death/HTx, and combined events were analyzed in the entire cohort and in a subgroup of 40 patients without sustained ventricular arrhythmia before diagnosis.

Results:

The 5-year cumulative probability of LTAE was 30% and HF-death/HTx was 10%. Predictors of HF-death/HTx were reduced right ventricle ejection fraction (HR: 0.93;
P
=0.010), HF symptoms (HR: 4.37;
P
=0.010), epsilon wave (HR: 4.99;
P
=0.015), and number of leads with low QRS voltage (HR: 1.28;
P
=0.001). Each additional lead with low QRS voltage increased the risk of HF-death/HTx by 28%. Predictors of LTAE were prior syncope (HR: 1.81;
P
=0.040), number of leads with T wave inversion (HR: 1.17;
P
=0.039), low QRS voltage (HR: 1.12;
P
=0.021), younger age (HR: 0.97;
P
=0.006), and prior ventricular arrhythmia/ventricular fibrillation (HR: 2.45;
P
=0.012). Each additional lead with low QRS voltage increased the risk of LTAE by 17%. In patients without ventricular arrhythmia before clinical diagnosis of ARVC, the number of leads with low QRS voltage (HR: 1.68;
P
=0.023) was independently associated with HF-death/HTx.

Conclusions:
Our study demonstrated the characteristics of a specific cohort with a high prevalence of arrhythmic burden at presentation, male predominance, younger age and HF severe outcomes. Our main results suggest that the presence and extension of low QRS voltage can be a risk predictor for HF-death/HTx in ARVC patients, regardless of the arrhythmic risk. This study can contribute to the global ARVC risk stratification, adding new insights to the international current scientific knowledge.
Angiotensin II Type 1 Receptor Blocker Prevents Abdominal Aortic Aneurysm Progression in Osteoprotegerin‐Deficient Mice via Upregulation of Angiotensin (1–7)
Authors: Karasaki Kohei , Kokubo Hiroki , Bumdelger Batmunkh , Kaji Nobuchika , Sakai Chiemi , Ishida Mari , Yoshizumi Masao 
Published: January 2023

Background
Angiotensin II type 1 receptor blockers (ARBs) have been shown to limit the growth of abdominal aortic aneurysm (AAA), but their efficacy is controversial. This study aimed to investigate the molecular mechanism underlying the protective effect of ARBs against AAA progression.

Methods and Results

Olmesartan, an ARB, was administered to wild‐type and
osteoprotegerin
‐knockout (
Opg
‐KO) mice starting 2 weeks before direct application of CaCl
2
to aortas to induce AAA. The protective effect of olmesartan against AAA in wild‐type and
Opg
‐KO mice was compared at 6 weeks after AAA induction. Olmesartan prevented AAA progression in
Opg
‐KO mice, including excessive aortic dilatation and collapse of tunica media, but not in wild‐type mice. Deficiency of the
Opg
gene is known to cause excessive activation of the tumor necrosis factor–related apoptosis‐inducing ligand–induced c‐Jun N‐terminal kinase/matrix metalloproteinase 9 pathway, resulting in prolonged AAA progression. Olmesartan attenuated the upregulation of phosphorylated c‐Jun N‐terminal kinase and matrix metalloproteinase 9 expression in the aortic wall of
Opg
‐KO mice. In cultured vascular smooth muscle cells, tumor necrosis factor–related apoptosis‐inducing ligand–induced c‐Jun N‐terminal kinase phosphorylation and matrix metalloproteinase 9 expression were inhibited by angiotensin (1–7), the circulating levels of which are increased by ARBs. Furthermore, administering an angiotensin (1–7) antagonist to
Opg
‐KO mice diminished the protective effect of olmesartan against AAA progression.

Conclusions

Olmesartan prevented AAA progression in
Opg‐
KO mice by upregulating angiotensin (1–7), suggesting that angiotensin (1–7) may be a key factor that mediates the protective effect of ARBs.
Gender and Working Roles in Television Commercials: A Comparison between Japanese and Thai Television Commercials
Authors: Pongsapitaksanti Piya 
Published: January 2023

Abstract
The research objective is to examine the similarities and differences of gender and working roles in Japanese and Thai television commercials. The research methodology focuses on content analysis. Seven hundred and sixty advertisements shown during 2016 in Japan and Thailand were analyzed. As a result, this comparative content analysis suggests a possible reversal from traditional patterns in the literature. Though the proportion of working women in Thailand is higher than the proportion in Japan, the proportions of working women in Japanese and Thai television commercials are insignificantly different. Moreover, this research result reveals the new appearance of non-stereotypical gender images in terms of the type of gender and working roles in commercials in these two Asian nations. These research findings support the supposition of a decrease in gender stereotyping in advertisements and suggest progress in stereotyped portrayals in advertising.
India’s GST Paradigm and the Trajectory of Fiscal Federalism: An Analysis with Special Reference to Kerala
Authors: Joseph K. J. , Kumary L. Anitha 
Published: January 2023

Since the design and implementation of GST is often perceived as a difficult task, especially in developing countries with federal constitutional structures, the introduction of GST in India in 2017 has been considered a great achievement. Against this background, this article explored the characteristics of India’s GST paradigm from a fiscal federal perspective, its implementation and the tax performance of States under GST. The Indianized GST paradigm, built on the edifice of GST Council and three key pillars of revenue neutrality, tax sharing between the Centre and the States and the provision for GST compensation, has been designed towards fostering cooperative federalism. Our analysis revealed that the revenue neutrality has not been ensured and there were also issues with tax sharing and GST compensation. Both the edifice and the pillars of GST, therefore, were fraught with fault lines in both the design and implementation. Tax effort of the States did not increase indicating that GST has not been helpful in improving the revenue position of the States. Although India’s GST paradigm was destined to foster cooperative federalism the outcomes appear to lead us towards coercive federalism. JEL Codes: H71, H73, H77
Prolactin in headache and migraine: A systematic review of clinical studies
Authors: Al-Karagholi Mohammad Al-Mahdi , Kalatharan Veberka , Ghanizada Hashmat , Gram Christian , Dussor Gregory , Ashina Messoud 
Published: January 2023

Objective To systemically review clinical studies investigating the role of prolactin and its receptors in headache and migraine. Background Migraine prevalence is more common in women compared to men. As prolactin is a crucial regulator of the hypothalamus-pituitary-gonadal axis, prolactin and its receptors might contribute to signaling mechanisms underlying migraine. Methods In this systematic review, we searched PubMed and EMBASE with the terms: prolactin, hyperprolactinemia, macroprolactinemia, hypoprolactinemia, migraine, headache, head pain and trigeminal pain pathway for clinical studies investigating prolactin signaling in headache and migraine. Two reviewers independently screened 841 articles for population, intervention, comparison, outcome, and study design. Studies were restricted to the English language and were excluded if they had a nonexperimental methodology. Results Nineteen clinical studies met the inclusion criteria and were included in the qualitative and quantitative analysis. The main findings were that serum prolactin levels were found to be higher in individuals with migraine compared to healthy controls, and prolactinomas (prolactin-secreting pituitary adenomas) were correlated with higher incidence of headache in otherwise healthy individuals and migraine attacks in individuals with migraine. Conclusion Considerable evidence suggests a key role of prolactin and its receptors in migraine pathophysiology. Further randomized and placebo-controlled clinical studies targeting prolactin signaling are needed to further clarify influences of prolactin in migraine attack initiation.
High serum leptin and adiponectin levels as biomarkers of disease progression in Egyptian patients with active systemic lupus erythematosus
Authors: Kamel Shaimaa M , Abdel Azeem (Abd Elazeem) Mervat E (Mervat I ) , Mohamed Rabab A , Kamel Mahmoud M , Abdel Aleem (Abdelaleem) Enas A 
Published: January 2023

Objectives: Leptin and adiponectin are adipose-derived immune modulators (adipokines) that may contribute to SLE pathology and symptoms. This study aimed to evaluate the associations of serum adiponectin and leptin with clinical manifestations and disease activity in SLE patients. Methods: This is a case control study, where 70 SLE patients and 50 age- and sex-matched healthy controls were enrolled from the Rheumatology and Rehabilitation Department of Beni-Suef University Hospital from June 2020 till April 2022. The SLE disease activity index (SLEDAI) and Systemic Lupus International Collaborative clinics/America Collage of Rheumatology damage index were used to assess disease severity. Laboratory parameters including erythrocyte sedimentation rate (ESR) and serum concentrations of antinuclear antibody (ANA), anti-double stranded DNA, complement 3 and 4, lipids, and C-reactive protein (CRP) were measured and compared between SLE and control groups. Serum adiponectin and leptin were also measured by enzyme-linked immunosorbent assays (ELISA). Results: Compared to healthy controls, SLE patients exhibited significantly greater serum leptin (21.1 vs 3.9 ng/mL, p < 0.001) and adiponectin (18.1 vs 4.8 ng/mL, p < 0.001), and both values were positively correlated with SLEDAI scores ( p = 0.048 and 0.042). Higher serum leptin was significantly associated with lupus nephritis (LN) ( p = 0.048) as well as greater body mass index ( p = 0.010), ESR ( p = 0.002), serum CRP ( p = 0.003), total cholesterol ( p = 0.013), and uric acid ( p = 0.002), while higher adiponectin was significantly associated with LN ( p = 0.046). Conclusion: Serum leptin and adiponectin levels are associated with the clinical and pathological manifestations of SLE, suggesting direct involvement in disease progression and utility as diagnostic biomarkers and therapeutic targets.
Methods and Ethics in Qualitative Research Exploring Young Children’s Voice: A Systematic Review
Authors: Sun Yihan , Blewitt Claire , Edwards Susan , Fraser Alexandra , Newman Shannon , Cornelius Julia , Skouteris Helen 
Published: January 2023

Young children have rights; they are agents and active constructors of their social worlds. Despite well-established theoretical foundations, the ‘methods’ and ‘ethics’ of qualitative research to elicit young children’s voice require further exploration to ensure young children are central to our research endeavors. This systematic review examined studies that sought to capture young children’s (3–6 years) voice in Early Childhood Education and Care settings. Fifty-eight studies met the inclusion criteria. Interview was found to be the most common strategy; this is often coupled with other child-friendly methods. Findings suggest that young children are increasingly listened to; however, there appears to be a need to further promote children’s agency and the inclusion of assent-seeking as an ongoing process. Gaps in methods supporting the inclusion of children with additional needs and Indigenous children are also evident. In addition, advancing non-permanent methods of meaning making to support children’s participation appears ripe for methodological innovation.
Perioperative therapeutic antibiotics are beneficial to prevent exacerbation of limb-associated infection after bypass surgery in patients with critical limb-threatening ischemia and foot infection score of ≥1
Authors: Matsubara Yutaka , Kawanami Shogo , Kinoshita Go , Kurose Shun , Shinichiro Yoshino , Morisaki Koichi , Furuyama Tadashi , Yoshizumi Tomoharu 
Published: January 2023

Objective Postoperative limb infection is associated with a poor prognosis and a low amputation-free survival rate after surgical revascularization in patients with critical limb-threatening ischemia. The Global Vascular Guidelines 2019 recommend antibiotic therapy for patients with deep space foot infection or wet gangrene; however, no study is cited as evidence for this recommendation. The present study was performed to offer new evidence supporting the use of perioperative therapeutic antibiotics in patients with critical limb-threatening ischemia (CLTI) undergoing surgical revascularization. Methods This single-center retrospective study was performed in Kyushu University Hospital and involved patients with CLTI who underwent surgical revascularization from 2003 to 2021. Ampicillin/sulbactam and cefazolin were defined as preventive antibiotics, and other types were defined as therapeutic antibiotics. Postoperative limb-associated infection was defined as an increased foot infection (fI) score in the Wound, Ischemia, and foot Infection (WIfI) classification system after surgical revascularization. The association between perioperative antibiotic therapy and postoperative limb-associated infection was assessed. Results Among 286 limbs of 263 patients with CLTI, 27 (9%) limbs developed postoperative limb-associated infection after surgical revascularization. The fI scores were significantly higher in the patients with than without postoperative limb-associated infection (1.0 ± 0.2 vs 0.4 ± 0.1, respectively; p = 0.0033), indicating that an fI score of ≥1 was a risk factor for postoperative limb-associated infection. Perioperative therapeutic antibiotics significantly reduced the incidence of postoperative limb-associated infection compared with preventive antibiotics (0.0% vs. 44.8%, respectively; p = 0.0028) in the patients with CLTI who had an fI score of ≥1 after bypass surgery, although perioperative therapeutic antibiotics were not effective for patients with an fI score of 0. Conclusion Perioperative therapeutic antibiotics for patients with an fI score of ≥1 are beneficial for reducing the incidence of postoperative limb-associated infection after surgical revascularization.
Examining the Impact of Polygenic Risk Information in Primary Care
Authors: Pacyna Joel E. , Ennis Jackson S. , Kullo Iftikhar J. , Sharp Richard R. 
Published: January 2023

Background: Polygenic risk testing examines variation across multiple genes to estimate a risk score for a particular disease, including risk scores for many common, chronic health conditions. Although polygenic risk information (PRI) may be a promising tool for enhancing preventive counseling and facilitating early identification of disease, its potential impact on primary-care encounters and disease prevention efforts has not been well characterized. Methods: We conducted in-depth, semi-structured interviews of patients to assess their understandings of PRI and their beliefs about its relevance to disease prevention. Results: We completed interviews with 19 participants. Participants described enthusiasm for the generation of PRI and recognized its utility for disease prevention. Participants also described the value of PRI as limited if not corroborated by non-genetic risk factors. Finally, participants noted that PRI, by itself, would be insufficient as a trigger for initiating many preventive interventions. Conclusion: PRI has the potential to become an important tool in primary care. However, patient views about PRI as well as the complexities of disease prevention in the primary care context may limit the impact of PRI on disease prevention.
Chloroplast genome sequence of triploid Toxicodendron vernicifluum and comparative analyses with other lacquer chloroplast genomes
Authors: Zong Dan , Qiao Zhensheng , Zhou Jintao , Li Peiling , Gan Peihua , Ren Meirong , He Chengzhong 
Published: January 2023

AbstractBackgroundToxicodendron vernicifluum, belonging to the family Anacardiaceae, is an important commercial arbor species, which can provide us with the raw lacquer, an excellent adhesive and painting material used to make lacquer ware. Compared with diploid, triploid lacquer tree has a higher yield of raw lacquer and stronger resistance to stress.TriploidT. vernicifluumwas a newly discovered natural triploid lacquer tree. However, the taxonomy of triploidT. vernicifluumhas remained uncertain. Here, we sequenced and analyzed the complete chloroplast (cp) genome of triploidT. vernicifluumand compared it with related species ofToxicodendrongenus based on chloroplast genome and SSR markers.ResultsThe plastome of triploidT. vernicifluumis 158,221 bp in length, including a pair of inverted repeats (IRs) of 26,462 bp, separated by a large single-copy region of 86,951 bp and a small single-copy region of 18,346 bp. In total, 132 genes including 87 protein-coding genes, 37 tRNA genes and 8 rRNA genes were identified in the triploidT. vernicifluum. Among these, 16 genes were duplicated in the IR regions, 14 genes contain one intron, while three genes contain two introns. After nucleotide substitutions, seven small inversions were analyzed in the chloroplast genomes, eight hotspot regions were found, which could be useful molecular genetic markers for future population genetics. Phylogenetic analyses showed that triploidT. vernicifluumwas a sister toT. vernicifluumcv. Dahongpao andT. vernicifluumcv. Hongpigaobachi. Moreover, phylogenetic clustering based on the SSR markers showed that all the samples of triploidT. vernicifluum,T. vernicifluumcv. Dahongpao andT. vernicifluumcv. Hongpigaobachi in one group, while the samples ofT. vernicifluumandT. succedaneumin another group, which is consistent with the cp genome and morphological analysis.ConclusionsThe current genomic datasets provide pivotal genetic resources to determine the phylogenetic relationships, variety identification, breeding and resource exploitation, and future genetic diversity-related studies ofT. vernicifluum.
Reliability of bioreactance and pulse power analysis in measuring cardiac index during cytoreductive abdominal surgery with hyperthermic intraperitoneal chemotherapy (HIPEC)
Authors: Ylikauma Laura Anneli , Tuovila Mari Johanna , Ohtonen Pasi Petteri , Erkinaro Tiina Maria , Vakkala Merja Annika , Takala Heikki Timo , Liisanantti Janne Henrik , Kaakinen Timo Ilari 
Published: January 2023

Abstract
Purpose
Various malignancies with peritoneal carcinomatosis are treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC). The hemodynamic instability resulting from fluid balance alterations during the procedure necessitates reliable hemodynamic monitoring. The aim of the study was to compare the accuracy, precision and trending ability of two less invasive hemodynamic monitors, bioreactance-based Starling SV and pulse power device LiDCOrapid with bolus thermodilution technique with pulmonary artery catheter in the setting of cytoreductive surgery with HIPEC.

Methods
Thirty-one patients scheduled for cytoreductive surgery were recruited. Twenty-three of them proceeded to HIPEC and were included to the study. Altogether 439 and 430 intraoperative bolus thermodilution injections were compared to simultaneous cardiac index readings obtained with Starling SV and LiDCOrapid, respectively. Bland-Altman method, four-quadrant plots and error grids were used to assess the agreement of the devices.

Results
Comparing Starling SV with bolus thermodilution, the bias was acceptable (0.13 l min− 1 m− 2, 95% CI 0.05 to 0.20), but the limits of agreement were wide (− 1.55 to 1.71 l min− 1 m− 2) and the percentage error was high (60.0%). Comparing LiDCOrapid with bolus thermodilution, the bias was acceptable (− 0.26 l min− 1 m− 2, 95% CI − 0.34 to − 0.18), but the limits of agreement were wide (− 1.99 to 1.39 l min− 1 m− 2) and the percentage error was high (57.1%). Trending ability was inadequate with both devices.

Conclusion
Starling SV and LiDCOrapid were not interchangeable with bolus thermodilution technique limiting their usefulness in the setting of cytoreductive surgery with HIPEC.
Exploring barriers to dementia screening and management services by general practitioners in China: a qualitative study using the COM-B model
Authors: Gong Ni , Yang Dan , Zou Jianfeng , He Qianyu , Hu Lei , Chen Weiju , Liao Jing 
Published: January 2023

AbstractBackgroundDementia has become a global public health problem, and general practitioners (GPs) play a key role in diagnosing and managing dementia. However, in Chinese primary care settings, dementia is underdiagnosed and inefficiently managed, and dementia screening and management services provided by GPs are suboptimal. The reasons underlying this gap are poorly understood. This study aimed to determine the barriers that hinder GPs from actively promoting dementia screening and management, and thereby provide insights for the successful promotion of dementia screening and management services in primary care.MethodsPurposive sampling was used. And focus groups and in-depth interviews were conducted face-to-face among GPs from community health service centers (CHSCs) in South China. Thematic analysis was used to identify barriers to screening and managing dementia and map them to the Capability/Opportunity/Motivation-Behavior model (COM-B model).ResultsFifty-two GPs were included. The COM-B model found nine barriers to implementing dementia screening and management services in primary healthcare: (1) poor capability: lack of systematic knowledge of dementia and inadequate dementia screening skills; (2) little opportunity: unclear pathways for referral, insufficient time for dementia screening and management, lack of dementia-specific leaders, and no guarantee of services continuity; (3) low motivation: outside of GP scope, worries associated with dementia stigma rooted in culture beliefs, and insufficient financial incentives.ConclusionsOur study concluded that GPs were not yet ready to provide dementia screening and management services due to poor capability related to knowledge and skills of dementia, little opportunity associated with an unsupportive working environment, and low motivation due to unclear duty and social pressure. Accordingly, systematic implementation strategies should be taken, including standardized dementia training programs, standardized community-based dementia guidelines, expansion of primary care workforces, development of dedicated leaders, and the eradication of stigma attached to dementia to promote dementia screening and management services in primary care.