bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of the effects of dexmedetomidine and remifentanil in sedation, analgesia, and vital signs in patients undergoing stereotactic brain biopsy: a single-blind control trial
Authors: Behnaz Faranak , Asgari Sogol , Bazgir Narges , Kordjazi Mohammadsmaeil , Sezari Parisa 
Published: May 2023

Abstract
Background: stereotactic frame-based brain biopsy is a minimally invasive neurosurgical procedure. Dexmedetomidine, an alpha-2 adrenergic agonist decreases heart rate, blood pressure, and stress response. Remifentanil is a short-acting opioid receptor agonist. In this study, we aim to compare the effects of dexmedetomidine and remifentanil on sedation, hemodynamic alterations, analgesia, and recovery profile of patients who underwent stereotactic brain biopsy.
Method: a single-blind clinical trial was conducted. Forty patients with American society of anesthesiology(ASA) class II were included. Initially, local anesthesia was administered and stereotactic frames were installed, then patients were transferred for magnetic resonance imaging (MRI) evaluations. Afterward, patients were randomly divided into two groups: The R group which received remifentanil, and the D group which received dexmedetomidine. Blood pressure, oxygen saturation, heart rate, and Ramsay sedation scale (RSS) of all included cases were recorded throughout the operation. After transferring to the post-anesthesia care unit (PACU), the visual analog score (VAS) and the amount of consumed morphine by each patient were measured.
The statistical analysis was conducted using SPSS version 22. Descriptive analysis, analysis of variance (ANOVA), and independent t-test were performed. A P-value less than 0.05 was considered to be statistically significant.
Results: forty consecutive patients consisting of 22 males and 18 females were included. Patients were randomly divided into two equal groups. After conducting statistical analysis, it was revealed that RSS was higher in the R group. Indicating a higher level of sedation. Heart rate, systolic blood pressure, and diastolic blood pressure were all higher in the D group. Furthermore, the VAS and consumed morphine were lower in the D group.
Conclusion: The RSS was higher in the R group, indicating a higher level of sedation in patients who received remifentanil. All recorded vital signs were higher in the D group. implicating that the vital signs were more stable during the operation in patients who received dexmedetomidine.
In addition, the VAS and dose of consumed morphine in PACU were lower in the D group.
Trial registration: the current study was registered in The Iranian registry clinical trial (code =IRCT20210415050983N2).
Global Sensitivity Analysis and Uncertainty Quantification for Design Parameters of Shallow Geothermal Systems
Authors: Richter Simon , Lubashevsky Katrin , Randow Jakob , Henker Steve , Bucher Anke 
Published: May 2023

Abstract
To improve the design process of geothermal systems, it is important to know which design parameters particularly affect the performance of the system. This article presents investigations on design parameters for borehole heat exchangers in the shallow subsurface. The study is based on numerical simulations with a double U-tube borehole heat exchanger and approximated models obtained using machine learning. As a result of the global sensitivity analysis, relevant parameters are identified and their respective influence on the performance of a borehole heat exchanger is compared. For example, according to this analysis, the three parameters with the highest sensitivity are: the initial temperature, the heat demand and the share of the borehole heat exchanger that is surrounded by groundwater flow. Finally, the effects of uncertainties in the parameters identified as relevant for the design of a borehole heat exchanger are considered in an uncertainty quantification for a fictitious site. Uncertainties for regulatory compliance with respect to temperature limits as well as a large probability of oversizing the system were identified for the considered example. The results of the exemplary uncertainty quantification indicate that it has the potential to be a useful tool for planning practice.
Unleashing the Power of Mother Nature: Investigating the Memory- Boosting Properties of Luteolin in Male Rats with Scopolamine-Induced Amnesia
Authors: Amini Niloufar , Chegini Azin , Zarrabian Shahram , Chegini Hamidreza 
Published: May 2023

Abstract

Background The present study aimed to determine the effect of luteolin on the performance of memory and learning in scopolamine-induced Alzheimer in male rats using a Y-shaped maze.Result The mean of spatial memory score declined in the scopolamine group with no change in the motor activity. In addition, luteolin prevented the decline in spatial memory with no alterations in the motor activity.Conclusion Luteolin prevented the scopolamine-induced declines of learning and memory in male rats.
The effects of etidronate on brain CALCIfications in FAhr’s DiseasE or syndrome: rationale and design of the randomised, placebo-controlled, double-blind CALCIFADE trial
Authors: Snijders Birgitta MG , Mathijssen Gini , Peters Mike JL , Emmelot-Vonk Marielle H , de Jong Pim A , Bakker Susan , Crommelin Heleen A , Ruigrok Ynte M , Brilstra Eva H , Schepers Vera PM , Spiering Wilko , Valen Evelien van , Koek Huiberdina L 
Published: May 2023

Abstract
Background Fahr’s disease and syndrome are rare disorders leading to calcification of the small arteries in the basal ganglia of the brain, resulting in a wide range of symptoms comprising cognitive decline, movement disorders and neuropsychiatric symptoms. No disease-modifying therapies are available. Studies have shown the potential of treatment of ectopic vascular calcifications with bisphosphonates. This paper describes the rationale and design of the CALCIFADE trial which evaluates the effects of etidronate in patients with Fahr’s disease or syndrome.Methods The CALCIFADE trial is a randomised, placebo-controlled, double-blind trial which evaluates the effects of etidronate 20 mg/kg during 12 months follow-up in patients aged ≥ 18 years with Fahr’s disease or syndrome. Etidronate and placebo will be administered in capsules daily for two weeks on followed by ten weeks off. The study will be conducted at the outpatient clinic of the University Medical Center Utrecht, The Netherlands. The primary endpoint is the change in cognitive functioning after 12 months of treatment. Secondary endpoints are the change in mobility, neuropsychiatric symptoms, volume of brain calcifications, dependence in activities of daily living, and quality of life.Results Patient recruitment started in April 2023. Results are expected in 2026 and will be disseminated through peer-reviewed journals as well as presentations at national and international conferences.Conclusions Fahr’s disease and syndrome are slowly progressive disorders with a negative impact on a variety of health outcomes. Etidronate might be a new promising treatment for patients with Fahr’s disease or syndrome.Trial registration ClinicalTrials.gov, NCT05662111. Registered 22 December 2022, https://clinicaltrials.gov/ct2/show/NCT01585402.
Structural differences between the closely related RNA helicases, UAP56 and URH49 fashions distinct functional apo-complexes
Authors: Masuda Seiji , Fujita Ken-ichi , Ito Misa , Irie Midori , Harada Kotaro , Fujiwara Naoko , Ikeda Yuya , Yoshioka Hanae , Yamazaki Tomohiro , Kojima Masaki , Mikami Bunzo , Mayeda Akila 
Published: May 2023

Abstract
Messenger RNA export is a regulated pathway that control gene expression and specific physiological events. In humans, closely related RNA helicases, UAP56 and URH49 shape selective mRNA export pathways through distinct apo-complex formation and remodeling to similar ATP-complex to achieve precise gene regulation. The difference in apo-complex is the key to functional divergence. However, the profile of the apo-complex formed by URH49 (named apo-AREX complex) and why UAP56 and URH49 exhibit distinct complex formation remain unknown. Here, we investigated unidentified apo-AREX components. RUVBL1, RUVBL2, ILF2, ILF3, and HNRNPM were physically and functionally associated with URH49, indicating the key components of the apo-AREX complex. Integrating analysis of crystal structure and complex formation of UAP56/URH49 chimera mutants demonstrated that their structural features contribute to respective complex formation. This study provides insights into the specific function of two helicases and into how two helicases diverged from a single ancestral gene, Sub2.
Science Teachers’ Perceptions of Social Media Platforms: An Exploration of Educational Instagram Pages
Authors: Doğru M. Said , Yüzbaşıoğlu Fatih 
Published: May 2023

Abstract

Instagram is one of the most widely used social media platforms around the world. It is not only a platform for users who want to spend time on social media, but also a platform where educators come together. This study aims to examine the views of science teachers on educational Instagram accounts. The sample was composed of 972 secondary science teachers and the data were collected through an online survey. The findings obtained from the online survey revealed the types of Instagram pages the participants valued the most, the criteria they used to select them, and the features they liked and disliked on these pages. The findings indicate that the participants generally benefit from Instagram in sharing resources related to science, communicating with their colleagues, following current information about their field of science, and contributing to their professional development. In addition, some of the features disliked by the participants about Instagram included late responses from administrators, off-topic posts and comments on the pages, and some limitations imposed by the platform. Overall, most of the participants find science-related Instagram pages valuable because they think that these pages increase their field-specific competencies. In conclusion, Instagram pages can be considered as a platform that can contribute to the professional development of science teachers specifically, and all teachers in general.
Integrating genome-wide association and expression quantitative trait loci (eQTL) analyses identifies genes affecting fertility in cattle and suggests a common set of genes regulating fertility in mammals
Authors: Forutan Mehrnush , Engle Bailey , Chamberlain Amanda , Ross Elizabeth , Nguyen Loan , D’Occhio Michael , Snr Alf Collins , Kho Elise , Fordyce Geoffry , Speight Shannon , Goddard Michael , Hayes Ben 
Published: May 2023

Abstract

Most genetic variants associated with fertility in mammals fall in non-coding regions of the genome and it is unclear how these variants affect fertility. Here we used genome-wide association (GWAS) summary statistics for heifer puberty (pubertal or not at 600 days) from 27,707 cattle; multi-trait GWAS signals from 2,119 cattle for four fertility traits, including days to calving, age at first calving, heifer pregnancy status, and foetus age in weeks; and expression quantitative trait locus (eQTL) for whole blood from 489 cattle, to identify 87 putatively functional genes affecting cattle fertility. Our analysis revealed a significant overlap between the set of cattle and human fertility-related genes. This finding implies the existence of a shared pool of genes that regulate fertility in mammals. These findings have important implications for the development of novel approaches to improve fertility in cattle and potentially in other mammals as well.
PPM1G dephosphorylates eIF4E to reduce selective mRNA translation.
Authors: Sonenberg Nahum , Wang Peng , Li Zixian , Kim Sunghoon , Huang Hao , Choi Jung-Hyun , Xu Haijin , yang chutong , Snape Abby , Bermudez Sara , Boivin Marie-Noëlle , Ferry Nicolas , Sood Rapita , Sharma Vijendra , Ryan Joel , Park Morag , Karamchandani Jason , Nagar Bhushan 
Published: May 2023

Abstract
The mRNA 5’cap-binding eukaryotic translation initiation factor 4E (eIF4E) plays a major role in control of mRNA translation in health and disease. One mechanism of regulation of eIF4E activity is via phosphorylation of eIF4E by MNK kinases, which promotes the translation of a subset of mRNAs encoding pro-tumorigenic and pro-inflammatory proteins. Work on eIF4E phosphatases has been paltry. Here, we show that PPM1G is the phosphatase that dephosphorylates eIF4E. We describe the binding motif in PPM1G that shares an eIF4E binding site with eIF4G and 4E-binding proteins (4E-BPs). We show that PPM1G is a nucleocytoplasmic shuttling protein that dephosphorylates eIF4E in the cytoplasm. We demonstrate that PPM1G inhibits cell proliferation and the phospho-eIF4E-dependent synthesis of several proteins involved in cell proliferation, survival, and inflammatory response.
Usefulness of fat-containing agents in research: an initial study of approximate bone fat content for magnetic resonance imaging
Authors: Takatsu Yasuo , Ohnishi Hiroshi , Tateyama Tomoko , Nohara Yuriko , Yamamura Kenichiro , Yabe Kunihiro , Miyati Tosiaki 
Published: May 2023

Abstract
Purpose To investigate the usefulness of commercially available fat-containing agents in magnetic resonance imaging (MRI) based on bone mineral measurement.Methods The proximal femurs obtained from 14 volunteers were analyzed by 0.3T MRI with a fat-containing nutrient solution (based on soybean oil, 10% and 20%), 100% soybean oil and saline as reference substances. Fat content was estimated based on the relationship between the intensities of the signals of the reference substances. Since this was an approximate value, it was set as the estimated fat fraction based on signal intensity (SIeFF, %). The SIeFF values of the femoral bone marrow, including the femoral head, neck, shaft, and trochanter area, were measured. Reference substances were set as close as possible to the outside of both proximal femurs. MRI data were compared in terms of bone mineral content (BMC) and bone mineral density (BMD) by dual-energy X-ray absorptiometry (DXA) in the proximal femur. MRI and DXA data were obtained on the same day.Results According to Pearson’s correlation coefficient, the SIeFF and total BMC and BMD data revealed strong and moderate inverse correlations in the femoral head (r < − 0.74) and other sites (r = − 0.66 to − 0.45), respectively.Conclusion Commercially available fat-containing agents may be useful in estimating the bone marrow fat content for bone mineral measurement by MRI. SIeFF and BMC and BMD showed a strong inverse correlation in the femoral head. Nevertheless, a more thorough study is warranted before this method can be used as an alternative to DXA.
Transfer Learning with CNNs for Efficient Prostate Cancer and BPH Detection in Transrectal Ultrasound Images
Authors: Huang Te-Li , Lu Nan-Han , Huang Yung-Hui , Twan Wen-Hung , Yeh Li-Ren , Liu Kuo-Ying , Chen Tai-Been 
Published: May 2023

Abstract
Purpose Early detection of prostate cancer (PCa) and benign prostatic hyperplasia (BPH) is crucial for maintaining the health and well-being of aging male populations. This study aims to evaluate the performance of transfer learning with convolutional neural networks (CNNs) for efficient classification of PCa and BPH in transrectal ultrasound (TRUS) images.Methods A retrospective experimental design was employed in this study, with 1,380 TRUS images for PCa and 1,530 for BPH. Seven state-of-the-art deep learning (DL) methods were employed as classifiers with transfer learning applied to popular CNN architectures. Performance indices, including sensitivity, specificity, accuracy, positive predictive value (PPV), negative predictive value (NPV), Kappa value, and Hindex (Youden's index), were used to assess the feasibility and efficacy of the CNN methods.Results The CNN methods with transfer learning demonstrated a high classification performance for TRUS images, with all accuracy, specificity, sensitivity, PPV, NPV, Kappa, and Hindex values surpassing 0.9400. The optimal accuracy, sensitivity, and specificity reached 0.9987, 0.9980, and 0.9980, respectively, as evaluated using two-fold cross-validation.Conclusion The investigated CNN methods with transfer learning showcased their efficiency and ability for the classification of PCa and BPH in TRUS images. Notably, the EfficientNetV2 with transfer learning displayed a high degree of effectiveness in distinguishing between PCa and BPH, making it a promising tool for future diagnostic applications.
Exposure therapy under psilocybin for general anxiety disorder and claustrophobia
Authors: THORENS Gabriel , PENZENSTADLER louise , FURTADO Leonice CAPRISTANO DE CARVALHO , SERAGNOLI Federico , ROTHEN Stephane , MABILAIS Cedric , ZULLINO Daniele 
Published: May 2023

Abstract
Case report of a patient with GAD and claustrophobia who underwent exposure therapy using psilocybin-assisted psychotherapy. The patient had failed to respond to conventional psychotherapeutic treatment. After three sessions of psilocybin-assisted psychotherapy, the patient experienced a reduction in anxiety and fear associated with closed spaces, elevators, and planes. The protocol included both an imaginary exposure exercise and a classic exposure therapy in an elevator during the psilocybin-assisted psychotherapy. the patient experienced a significant improvement in his score on the Beck Depression Inventory-II (BDI-II), the State-Trait Anxiety Inventory (STAI), and the Fear Questionnaire before and after therapy. He reported a generalization of the treatment effects, feeling more relaxed and having a greater willingness to confront fearful situations. He also described a shift in his perception of fearful stimuli, which may be explained as the development of new memory representations and a major disconfirmatory experience.
Enterprise risk management implementation challenges in the Zimbabwean medical laboratory industry
Authors: Vhanda Donald , Chinowaita Frank , Chinowaita Kudzai , Vhanda Reynold , Nherera Brenda , Dzinamarira Tafadzwa , Chitungo Itai James Blessing 
Published: May 2023

Abstract
Background.
Of late there has been increasing interest in risk management (RM) across the world due to the global financial crisis’s impact on the world economy and also the changing business environment characterized by threats from economic, political, natural and technical resources. Health care organizations including medical laboratories are environments characterised by high management complexity and they are subject to a constant exposure to risks. The objective of the study was to investigate the ERM implementation challenges in the Zimbabwe medical laboratories sector.
Methodology.
A cross-sectional survey through 41 self-administered questionnaires and interviews with medical laboratory staff from the 6 main medical laboratories in Zimbabwe.
Results.
The main challenges identified in the study included increased workload, staffing, organisational structures, timeliness of information, inadequate information technology support and insufficient financial support in ERM.
Conclusion.
The findings of this study give a critical insight into the key elements that need to be tackled as a starting point for a successful implementation of ERM in the medical laboratory sector in Zimbabwe. ERM is still a new approach in the sector and needs further research.
Divergently Access N-center 5,6,7-Perifused Cycle
Authors: Li Baosheng , Han Jingpeng , Yang Yongjian , Gong Yingjian , Tang Xuan , Tian Yi 
Published: May 2023

Abstract
Nitrogen-containing heterocycles are the key components in many pharmaceuticals and functional materials. In this study, we reported a transition metal-catalyzed high-order reaction sequence for synthesizing a structurally unique N-center 5,6,7-perifused cycle (NCPC). The key characteristics included the formation of a seven-membered ring by the 8π electrocyclization of various alkenes and aromatic heterocycles as π-components, in which metal carbene species generated that further induced the cleavage of the α-C-H or -C-C bond. Specifically, the latter could react with various nucleophilic reagents containing -O, -S, -N, and -C. The stereo-controlled late-stage modification of some complicated pharmaceuticals indicated the versatility of this protocol.
The effect of pelvicalyceal anatomy on reaching the lower calyx and comparison between reusable and single-use flexible ureteroscopes
Authors: Taguchi Makoto , Yasuda Kaneki , Kinoshita Hidefumi 
Published: May 2023

Abstract
Objective: To investigate reaching the lower calyx during flexible ureteroscopic lithotripsy (URSL) using flexible ureteroscopes (including single-use scopes (LithoVue) and reusable scopes (P5 and P7)) and examine the risk factors of pelvicalyceal anatomy on reaching the lower calyx with active deflection.
Methods: We performed a retrospective review of prospectively collected data for 162 patients who underwent URSL at our hospital. URSL was performed using 1.5 Fr basket and two laser fibers (200 μ and 365 μ). We measured the infundibular length (IL), infundibular width, infundibulopelvic angle, infundibular distance (ID), and infundibular angle (IDA) and recorded the success rate of reaching the lower calyx by four methods (channel free, 1.5 Fr basket, 200 μ laser, and 365 μ laser).
Results: When using the 365 μ laser, the success rates for reaching the lower calyx significantly differed: 84.3% (LithoVue), 55.1% (P5), and 60.5% (P7). Multivariate analysis revealed that the following significant factors affect the success of reaching the lower calyx with active deflection: using LithoVue, IDA, IL, and ID. The cut-off points of the receiver operating characteristic curve of IDA and IL were 30 degrees and 22.4 mm, respectively.
Conclusion: The type of scopes and pelvicalyceal anatomy strongly affect the success rate of reaching the lower calyx. If the IDA is sharp or the IL is long, flexible ureteroscopes may not reach the lower calyx with active deflection.
Detection of primary paleomagnetic remanence carriers in zircon crystals using high-resolution X-ray ptycho-tomography
Authors: Kupp Venkata Sree Charan , Ball Matthew , Batey Darren , Dodds Kathryn , Cipiccia Silvia , Wanelik Kaz , Fu Roger , Rau Christoph , Harrison Richard 
Published: May 2023

Abstract
We present the first application of X-ray ptycho-tomography to perform high-resolution, non-destructive, three-dimensional (3D) imaging of magnetic inclusions in paleomagnetically relevant materials (zircon crystals from the Bishop Tuff ignimbrite). Correlative microscopy using quantum diamond magnetic microscopy combined with X-ray fluorescence mapping was used to locate regions containing Fe-bearing magnetic remanence carriers. Ptycho-tomographic reconstructions with voxel sizes 85 nm and 21 nm were achievable across a field-of-view > 80 µm; voxel sizes as small as 5 nm were achievable over a limited field-of-view using local ptycho-tomography. Magnetite particles 300 nm in size were clearly resolved. We estimate that particles as small as 100 nm – approaching single-domain threshold for magnetite – could be resolvable using this “dual-mode” methodology. Our combined magnetic and tomography results support the presence of primary magnetic inclusions in relatively young and pristine zircon crystals, majority of which are in the optimal size range for carrying strong and stable paleomagnetic signals.