bluuebunny/crossref_metadata_2025_split huggingface dataset:
Contribution of private health services to universal health coverage in low and middle‐income countries: Factors affecting the use of private over public health services in Vietnam
Authors: Nguyen Mai P. , Tariq Amina , Hinchcliff Reece , Luu Hoat N. , Dunne Michael P. 
Published: July 2023

AbstractThe private sector's contribution to Universal health coverage (UHC) has been increasingly recognised by policymakers in low‐ and middle‐income countries. This study aimed to identify service‐provider and consumer‐level factors affecting choice of private over public health services in Vietnam. A concurrent mixed‐method design was adopted. A quantitative phase explored consumers' health service choice by analysing data from a random national sample of 10,354 individuals aged 16 and over. The qualitative phase investigated how private and public providers organise their services to influence consumer choices by conducting interviews with policymakers, hospital and clinic managers, and health practitioners. The combined results demonstrate that at the individual level, absence of any type of health insurance was the factor most closely associated with the use of private services. Private health services were more likely to be used by people from ethnic majority groups compared to ethnic minorities (odds ratio [OR]: 1.6, 95% CI: 1.4–2.0), and by people living in urban compared to rural areas (OR: 1.1, 95% CI: 1.0–1.3). The service providers suggested that consumers opted for private services that were perceived to have poorer quality in the public sector, such as counselling, physical therapy and rehabilitative care. Additional motivational factors include the private sector's more flexible working hours, shorter waiting times, flexible pricing of services, personalised care and better staff behaviour. The findings can inform national health system planning and coordination activities in Vietnam and other countries that aim to harness the attributes of both the public and private sectors to achieve UHC.
Teaching clinicians and nurses to prepare for and present at interdisciplinary meetings through behavioral skills training
Authors: Harper Jill M. , Bird Frank , Wizboski Maria , Steinhauser Haley , Luiselli James K. 
Published: July 2023

AbstractBehavior analysts frequently collaborate with interdisciplinary colleagues to share information and make decisions about client services. This study evaluated the effects of behavioral skills training on preparation for and presentation during interdisciplinary review team meetings by clinicians (n = 4) and nurses (n = 4) at a residential school for students with intellectual and neurodevelopmental disabilities. The primary dependent measure was the percentage of preparation and presentation steps from task‐analyzed behavior checklists that the participants implemented correctly. As evaluated by multiple‐baseline designs, the participants improved their preparation and presentation skills to nearly 100% following behavioral skills training, maintained performance 1 month after the study, and rated training positively. We discuss elements of the training program, practice implications, and research directions.
Low‐dose ketamine improves animals' locomotor activity and decreases brain oxidative stress and inflammation in ammonia‐induced neurotoxicity
Authors: Ommati Mohammad Mehdi , Mobasheri Ali , Niknahad Hossein , Rezaei Mohammad , Alidaee Sepideh , Arjmand Abdollah , Mazloomi Sahra , Abdoli Narges , Sadeghian Issa , Sabouri Samira , Saeed Mohsen , Mousavi Khadijeh , Najibi Asma , Heidari Reza 
Published: July 2023

AbstractAmmonium ion (NH4+) is the major suspected molecule responsible for neurological complications of hepatic encephalopathy (HE). No specific pharmacological action for NH4+‐induced brain injury exists so far. Excitotoxicity is a well‐known phenomenon in the brain of hyperammonemic cases. The hyperactivation of the N‐Methyl‐
d‐aspartate (NMDA) receptors by agents such as glutamate, an NH4+ metabolite, could cause excitotoxicity. Excitotoxicity is connected with events such as oxidative stress and neuroinflammation. Hence, utilizing NMDA receptor antagonists could prevent neurological complications of NH4+ neurotoxicity. In the current study, C57BL6/J mice received acetaminophen (APAP; 800 mg/kg, i.p) to induce HE. Hyperammonemic animals were treated with ketamine (0.25, 0.5, and 1 mg/kg, s.c) as an NMDA receptor antagonist. Animals' brain and plasma levels of NH4+ were dramatically high, and animals' locomotor activities were disturbed. Moreover, several markers of oxidative stress were significantly increased in the brain. A significant increase in brain tissue levels of TNF‐α, IL‐6, and IL‐1β was also detected in hyperammonemic animals. It was found that ketamine significantly normalized animals' locomotor activity, improved biomarkers of oxidative stress, and decreased proinflammatory cytokines. The effects of ketamine on oxidative stress biomarkers and inflammation seem to play a key role in its neuroprotective mechanisms in the current study.
Gastro‐protective effect of l‐arginine against nitric oxide deficiency‐related mucosal injury induced by indomethacin: Does age matter?
Authors: Heeba Gehan H. , Morsy Mohamed A. , Mahmoud Magda E. , Abdel‐latif Rania 
Published: July 2023

AbstractGastric ulcer is a common disease with increased prevalence in the aged population. Aged gastric mucosa has increased susceptibility to injury along with nonsteroidal anti‐inflammatory drugs use due to impaired mucosal defense and decreased vasodilator release. We investigated whether l‐arginine could protect against age‐related gastric ulceration induced by indomethacin. Aged and adult male Wistar rats were administered sole and combined treatment of
l‐arginine and Nω‐nitro‐l‐arginine methyl ester (
l‐NAME) before induction of gastric ulceration by indomethacin. The gastroprotective effect of
l‐arginine was displayed only in adult rats with indomethacin‐induced gastric ulceration, as evidenced by a significant decrease in ulcer index, oxidative stress parameters, and mucosal myeloperoxidase activity along with increased mucosal PGE2 levels. Interestingly, the mucosal gene expressions of NF‐кB, iNOS, and COX‐2 were significantly suppressed by
l‐arginine pretreatment and aggregated upon pretreatment with
l‐NAME in both adult and aged rats treated with indomethacin. In conclusion,
l‐arginine protected the rats' gastric mucosa against indomethacin‐induced gastric ulceration, possibly, at least in part, by enhancement of mucosal nitric oxide/PGE2 content along with suppressing gastric inflammation and oxidative stress. This study supposed that the gastroprotective effect of
l‐arginine depends on aging, and even so, the adoption of a new approach to gastric ulcer treatment for the aged population is warranted.
Gendered time poverty in three developing countries: An intra‐household analysis of children's time use
Authors: Khanna Madhulika , Thomas Milan 
Published: July 2023

AbstractAdvances in data collection and methodology have contributed to the rise of time use as a topic of economic analysis, but much of the research focuses on adults in advanced economies. We document gendered differences in the intra‐household allocation of children's time in Ethiopia, India, and Vietnam based on the Young Lives Longitudinal Study. Using household fixed effects regressions, we document a leisure deficit for girls, highlighting a gender gap that has received less attention. We use the concept of time poverty to further investigate the nature of the leisure deficit, applying a relative time poverty line. A gender gap in the incidence of time poverty emerges at an early age and is spread across the wealth distribution. Our findings relate to the literature on time poverty of women in developing countries and have implications for promoting gender equality under Sustainable Development Goal target 5.4 on unpaid care and domestic work.
USF1‐mediated ALKBH5 stabilizes FLII mRNA in an m6A‐YTHDF2‐dependent manner to repress glycolytic activity in prostate adenocarcinoma
Authors: Fu Dewang , Si Qingyue , Yu Chenxi , Han Zhifu , Zang Li'e 
Published: July 2023

AbstractUpstream‐stimulating factor 1 (USF1) is a ubiquitously expressed transcription factor implicated in multiple cellular processes, including metabolism and proliferation. This study focused on the function of USF1 in glycolysis and the malignant development of prostate adenocarcinoma (PRAD). Bioinformatics predictions suggested that USF1 is poorly expressed in PRAD. The clinical PRAD samples revealed a low level of USF1, which was correlated with an unfavorable prognosis. Artificial upregulation of USF1 significantly repressed glycolytic activity in PRAD cells and reduced cell growth and metastasis in vitro and in vivo. Potential downstream genes of USF1 were probed by integrated bioinformatics analyses. The chromatin immunoprecipitation and luciferase assays indicated that USF1 bound to the α‐ketoglutarate‐dependent dioxygenase alkB homolog 5 (ALKBH5) promoter for transcription activation. Flightless I (FLII) was identified as the gene showing the highest degree of correlation with ALKBH5. As an m6A demethylase, ALKBH5 enhanced FLII mRNA stability by inducing m6A demethylation in an m6A‐YTH N6‐methyladenosine RNA‐binding protein F2 (YTHDF2)‐dependent manner. Either silencing of ALKBH5 or FLII blocked the role of USF1 in PARD cells and restored glycolysis, cell proliferation, and invasion. This study demonstrates that USF1 activates ALKBH5 to stabilize FLII mRNA in an m6A‐YTHDF2‐dependent manner, thereby repressing glycolysis processes and the progression of PRAD.
Phosphatidylserine decarboxylase downregulation in uric acid‑induced hepatic mitochondrial dysfunction and apoptosis
Authors: Liu Ning , Huang Lei , Xu Hu , He Xinyu , He Xueqing , Cao Jun , Xu Wenjun , Wang Yaoxing , Wei Hongquan , Wang Sheng , Zheng Hong , Gao Shan , Xu Youzhi , Lu Wenjie 
Published: July 2023

AbstractThe molecular mechanisms underlying uric acid (UA)‐induced mitochondrial dysfunction and apoptosis have not yet been elucidated. Herein, we investigated underlying mechanisms of UA in the development of mitochondrial dysfunction and apoptosis. We analyzed blood samples of individuals with normal UA levels and patients with hyperuricemia. Results showed that patients with hyperuricemia had significantly elevated levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels, which may indicate liver or mitochondrial damage in patients with hyperuricemia. Subsequently, lipidomic analysis of mouse liver tissue mitochondria and human liver L02 cell mitochondria was performed. Compared with control group levels, high UA increased mitochondrial phosphatidylserine (PS) and decreased mitochondrial phosphatidylethanolamine (PE) levels, whereas the expression of mitochondrial phosphatidylserine decarboxylase (PISD) that mediates PS and PE conversion was downregulated. High UA levels also inhibited signal transducer and activator of transcription 3 （STAT3） phosphorylation as well as mitochondrial respiration, while inducing apoptosis both in vivo and in vitro. Treatment with allopurinol, overexpression of PISD, and lyso‐PE (LPE) administration significantly attenuated the three above‐described effects in vitro. In conclusion, UA may induce mitochondrial dysfunction and apoptosis through mitochondrial PISD downregulation. This study provides a new perspective on liver damage caused by hyperuricemia.
Dystonia Linked to EIF4A2 Haploinsufficiency: A Disorder of Protein Translation Dysfunction
Authors: Harrer Philip , Škorvánek Matej , Kittke Volker , Dzinovic Ivana , Borngräber Friederike , Thomsen Mirja , Mandel Vanessa , Svorenova Tatiana , Ostrozovicova Miriam , Kulcsarova Kristina , Berutti Riccardo , Busch Hauke , Ott Fabian , Kopajtich Robert , Prokisch Holger , Kumar Kishore R. , Mencacci Niccolo E. , Kurian Manju A. , Di Fonzo Alessio , Boesch Sylvia , Kühn Andrea A. , Blümlein Ulrike , Lohmann Katja , Haslinger Bernhard , Weise David , Jech Robert , Winkelmann Juliane , Zech Michael 
Published: July 2023

AbstractBackgroundProtein synthesis is a tightly controlled process, involving a host of translation‐initiation factors and microRNA‐associated repressors. Variants in the translational regulator EIF2AK2 were first linked to neurodevelopmental‐delay phenotypes, followed by their implication in dystonia. Recently, de novo variants in EIF4A2, encoding eukaryotic translation initiation factor 4A isoform 2 (eIF4A2), have been described in pediatric cases with developmental delay and intellectual disability.ObjectiveWe sought to characterize the role of EIF4A2 variants in dystonic conditions.MethodsWe undertook an unbiased search for likely deleterious variants in mutation‐constrained genes among 1100 families studied with dystonia. Independent cohorts were screened for EIF4A2 variants. Western blotting and immunocytochemical studies were performed in patient‐derived fibroblasts.ResultsWe report the discovery of a novel heterozygous EIF4A2 frameshift deletion (c.896_897del) in seven patients from two unrelated families. The disease was characterized by adolescence‐ to adulthood‐onset dystonia with tremor. In patient‐derived fibroblasts, eIF4A2 production amounted to only 50% of the normal quantity. Reduction of eIF4A2 was associated with abnormally increased levels of IMP1, a target of Ccr4‐Not, the complex that interacts with eIF4A2 to mediate microRNA‐dependent translational repression. By complementing the analyses with fibroblasts bearing EIF4A2 biallelic mutations, we established a correlation between IMP1 expression alterations and eIF4A2 functional dosage. Moreover, eIF4A2 and Ccr4‐Not displayed significantly diminished colocalization in dystonia patient cells. Review of international databases identified EIF4A2 deletion variants (c.470_472del, c.1144_1145del) in another two dystonia‐affected pedigrees.ConclusionsOur findings demonstrate that EIF4A2 haploinsufficiency underlies a previously unrecognized dominant dystonia‐tremor syndrome. The data imply that translational deregulation is more broadly linked to both early neurodevelopmental phenotypes and later‐onset dystonic conditions. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
Crosstalk between cancer cells and the nervous system
Authors: Huang Meng , Gong Gu , Deng Yicheng , Long Xinmiao , Long Wenyong , Liu Qing , Zhao Wei , Chen Rufu 
Published: July 2023

AbstractCrosstalk between tumors and the nervous system has emerged as a significant hallmark of human cancer. In the central nervous system, neurons closely interact with tumor cells, promoting the proliferation of glioma and neuroblastoma. Additionally, the peripheral nervous system plays a crucial role in reshaping the tumor microenvironment, modulating angiogenesis, and regulating immune cell function, while also directly promoting tumorigenesis and metastasis. Current research has elucidated some of the specific neural signaling mechanisms involved in this crosstalk, including neurotransmitters, neuropeptides, and growth factors. In this review, we aim to summarize these mechanisms and highlight the latest discoveries in various solid tumors, such as glioma, pancreatic, prostate, and gastrointestinal cancers. By understanding the intricate crosstalk between cancer cells and the nervous system, we can develop more effective and targeted treatments for cancer patients.
A high gain uniplanar end‐fire electrically small antenna with a spilt‐ring resonator loading
Authors: Chen Chunling 
Published: July 2023

AbstractThis letter presents a design of a high gain uniplanar end‐fire electrically small antenna. The design starts from an equivalent antenna of an antenna array with two half‐wavelength dipoles, which consists of two linear strips and produces the end‐fire unidirectional radiation. Two U‐shaped strips are utilized to replace the linear strips, which makes the antenna compact. In addition, a spilt‐ring resonator is loaded to make the realized gain of the electrically small antenna increase by ~2 dB. An antenna prototype is fabricated and measured. The measurements reveal that the proposed antenna has a peak realized gain of 6.02 dBi and a front‐to‐back ratio of 12.71 dB at its resonance frequency of 747.8 MHz. Its size is only 0.254 λ0 × 0.184 λ0 × 0.0037 λ0, and ka = 0.984. The measured realized gain exceeds both the Harrington and Kildal–Best ka‐based upper limits.
Recent progress in Epoxy Nanocomposites: Corrosion, structural, flame retardancy and applications — A comprehensive review
Authors: Zaghloul Moustafa Mahmoud Yousry , Zaghloul Mai Mahmoud Yousry , Fuseini Mohammed 
Published: July 2023

AbstractIn the past few years, epoxy resins utilization has gained much significant recognition from researchers worldwide as a result of its advantages in different sectors such as automotive, aerospace, electronic systems, constructions, and other related fields because of its outstanding mechanical performance, corrosion protection, and dielectric properties. The nanomaterials incorporation into the matrix has been duly examined to be the most productive route to enhance polymer composite's mechanical properties. Despite that, the inherent brittleness, relatively low fracture toughness, cross‐linking ability, poor electrical, and thermal properties of epoxy render it weak to growth and initiation of cracks, limiting its utilization in state‐of‐the‐art structural applications. Especially, epoxy is flammable while releasing a considerable amount of gases and smoke, thus, extending a potential risk to lives. Consequently, several nanofiller materials like graphene (Gr), transition metal dichalcogenides, MXene, and hexagonal boron nitride (h‐BN) produce extensive chances to equip multi‐functional characteristics and then reinforce the epoxy resins for the state‐of‐the‐art application. With this current review, the present literature investigation of epoxy filled with nano‐sized material has been examined thoroughly. Current advances in the approach of integrating nanosized materials in the epoxy matrices have been also introduced. Most significantly, anti‐corrosion, mechanical, and flame‐retardant properties of nanomaterials reinforced epoxy nanocomposites have also been reviewed in particular. Ultimately, the present statuses of the field in addition to the future approach have been considered concerning the usefulness of numerous nanofillers toward reinforcement of epoxy in construction and building materials. The expectation in this extensive review could produce a valuable reference, ingenuity, and guidance for researchers in this area of study.
All organic polymer dielectrics for high‐temperature energy storage from the classification of heat‐resistant insulation grades
Authors: Liang Yujie , Sun Wenjie , Li Tianyu , Chen Yue , Cheng Yonghong , Zhang Lei 
Published: July 2023

AbstractDielectric film capacitors for high‐temperature energy storage applications have shown great potential in modern electronic and electrical systems, such as aircraft, automotive, oil exploration industry, and so on, in which polymers are the preferred materials for dielectric capacitors. This review tries to summarize the recent progress in the field of energy storage based on heat‐resistant all‐organic polymers from the perspective of their operating temperatures. Based on this, a summary of commonly used and latest research on high‐temperature polymers is conducted, and they are classified into different heat‐resistant insulation grades, consequently providing a new perspective for high‐temperature polymers dielectric research, especially on the selection of them under different occasions. Emphasis is placed on the influencing factors of polymer performance and ways to develop high‐temperature polymers. Especially, properties under high temperature including dielectric constant and loss, glass transition temperature, and energy density are summarized, inspiring researchers devoting further efforts in this area. A future prospect in this field is also discussed.
Pediatric Pulmonology 2022 year in review: Rare and diffuse lung disease
Authors: Barber Andrew T. , Liptzin Deborah R. , Gower William A. , Hinds Daniel M. 
Published: July 2023

AbstractThe field of rare and diffuse pediatric lung disease continues to evolve and expand rapidly as clinicians and researchers make advancements in the diagnosis and treatment of children's interstitial and diffuse lung disease, non‐cystic fibrosis bronchiectasis, and primary ciliary dyskinesia. Papers published on these topics in Pediatric Pulmonology and other journals in 2022 describe newly recognized disorders, elucidate disease mechanisms and courses, explore potential biomarkers, and assess novel treatments. In this review, we will discuss these important advancements and place them in the context of existing literature.
ARAS method based on Z‐numbers in FMEA
Authors: Adalı Esra Aytaç , Tuş Ayşegül 
Published: July 2023

AbstractFailure Mode and Effects Analysis (FMEA) is one of the risk assessment methods, and is widely applied to the various areas in real life. The method has two main phases. In the first phase, the potential failure modes of products, processes, systems, and services are determined, whereas in the second phase, the risk assessment and prioritization of these failure modes are made, and preventive and corrective actions are taken to prevent the emergence of failure modes with relatively higher risk. Although the method is widely used over the years, researchers have used FMEA together with different theories and methods to overcome several shortcomings of the method. In this study, a new method, Z‐ARAS (Additive Ratio ASsessment), is proposed on a risk analysis in FMEA to eliminate uncertainty information in decision‐making practice. This method is the modification of ARAS method by integrating with Z‐numbers. Z‐numbers are performed to reflect the reliability of decision makers’ evaluations. A real case covering a cable company's production failures that is adopted from the literature is solved to demonstrate the applicability of the proposed method. A sensitivity analysis is performed, and also a comparative analysis is presented with Z‐MARCOS (Measurement Alternatives and Ranking according to the COmpromise Solution) and Z‐CODAS (COmbinative Distance‐based ASsessment) methods to highlight the effectiveness of Z‐ARAS method. It can be concluded that Z‐ARAS is an alternative method to detect and analyze critical failure modes, and assist decision makers in implementing a reliable preventive strategy.
Case report: Crossed fused renal ectopia with stones: A surgical challenge overcome by robotic surgery
Authors: Chai Jiagui , Ke Changxing 
Published: July 2023

AbstractBackgroundCrossed fused renal ectopia (CFRE) is an extremely rare congenital anomaly of the urinary tract that is prone to stone formation. The surgical treatment of CFRE with stones is challenging due to anatomical abnormalities.Materials and MethodsRight kidney stones were treated by flexible ureteroscopic lithotripsy (FURSL) and left kidney stones were treated by robotic surgery.ResultsThe authors present an unreported case of bilateral renal stones in a patient with CFRE, which was successfully treated by robotic pyelolithotomy combined with FURSL. The procedure was manoeuverable, and the stone‐free rate was satisfactory.ConclusionsCFRE with stones (S‐shaped kidney) present a surgical challenge due to anatomical abnormalities and a high stone burden. The authors recommend robotic pyelolithotomy with or without FURSL as a viable treatment option for stones with similar anatomical abnormalities.