bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dynamic Activation of Ga Sites by Pt Dopant in Low‐Temperature Liquid‐Metal Catalysts
Authors: Lambie Stephanie , Steenbergen Krista G. , Gaston Nicola 
Published: February 2023

AbstractLiquid GaPt catalysts with Pt concentrations as low as 1×10−4 atomic % have recently been identified as highly active for the oxidation of methanol and pyrogallol under mild reaction conditions. However, almost nothing is known about how liquid state catalysts support these significant improvements in activity. Here, ab initio molecular dynamics simulations are employed to examine GaPt catalysts in isolation and interacting with adsorbates. We find that persistent geometric features can exist in the liquid state, given the correct environment. We postulate that the Pt dopant may not be limited to direct involvement in catalysis of reactions, but rather that its presence can also enable Ga atoms to become catalytically active.
Post‐Assembly Modification of Homochiral Titanium–Organic Cages for Recognition and Separation of Molecular Isomers
Authors: Chen Guang‐Hui , He Yan‐Ping , Yu Yinghua , Lv Hong , Li Shangda , Wang Fei , Gu Zhi‐Gang , Zhang Jian 
Published: February 2023

AbstractA chiral metal–organic cage (MOC) was extended and fixed into a porous framework using a post‐assembly modification strategy, which made it easier to study the host–guest chemistry of the solid‐state MOC using a single‐crystal diffraction technique. Anionic Ti4L6 (L=embonate) cage can be used as a 4‐connecting crystal engineering tecton, and its optical resolution was achieved, thus homochiral ΔΔΔΔ‐ and ΛΛΛΛ‐[Ti4L6] cages were obtained. Accordingly, a pair of homochiral cage‐based microporous frameworks (PTC‐236(Δ) and PTC‐236(Λ)) were easily prepared by a post‐assembly reaction. PTC‐236 has rich recognition sites provided by the Ti4L6 moieties, chiral channels and high framework stability, affording a single‐crystal‐to‐single‐crystal transformation for guest structure analyses. Thus it was successfully utilized for the recognition and separation of isomeric molecules. This study provides a new approach for the orderly combination of well‐defined MOCs into functional porous frameworks.
Tricrilactones A–H, Potent Antiosteoporosis Macrolides with Distinctive Ring Skeletons fromTrichocladium crispatum, an Alpine Moss‐Associated Fungus
Authors: Han Wen‐Bo , Zhai Yi‐Jie , Zhang Rong , Gong Xu‐Shun , Li Jia‐Qian , Xu Gong , Lei Xinxiang , Du Liangcheng , Gao Jin‐Ming 
Published: February 2023

AbstractTricrilactones A–H (1–8), a new family of oligomeric 10‐membered macrolides featuring collectively five unique ring skeletons, were isolated from a hitherto unexplored fungus,Trichocladium crispatum. Compounds1and7contain two unconventional bridged (aza)tricyclic core skeletons,2,3,5, and6share an undescribed tetracyclic 9/5/6/6 ring system,4bears an uncommon 9/5/6/10/3‐fused pentacyclic architecture, and8is a dimer bridged by an unexpected C−C linkage. Their structures, including absolute configurations, were elucidated by spectroscopic analysis, quantum chemical calculations, and X‐ray diffraction analysis. Importantly, the absolute configuration of the highly flexible side chain of1was resolved by the asymmetric synthesis of its four stereoisomers. The intermediate‐trapping and isotope labeling experiments facilitated the proposal of the biosynthetic pathway for these macrolides. In addition, their antiosteoporosis effects were evaluated in vivo (zebrafish).
Manipulating Host‐Guest Charge Transfer of a Water‐Soluble Double‐Cavity Cyclophane for NIR‐II Photothermal Therapy
Authors: Li Ran , Yang Fei , Zhang Liying , Li Mengzhen , Wang Guo , Wang Weizhi , Xu Yanqing , Wei Wei 
Published: February 2023

AbstractWater‐soluble small organic photothermal agents (PTAs) over NIR‐II biowindow (1000–1350 nm) are highly desirable, but the rarity greatly limits their applications. Based on a water‐soluble double‐cavity cyclophane GBox‐44+, we report a class of host–guest charge transfer (CT) complexes as structurally uniform PTAs for NIR‐II photothermal therapy. As a result of its high electron‐deficiency, GBox‐44+ can bind different electron‐rich planar guests with a 1 : 2 host/guest stoichiometry to readily tune the CT absorption band that extends to the NIR‐II region. When using a diaminofluorene guest substituted with an oligoethylene glycol chain, the host–guest system realized both good biocompatibility and enhanced photothermal conversion at 1064 nm, and was then exploited as a high‐efficiency NIR‐II PTA for cancer cell and bacterial ablation. This work broadens the potential applications of host–guest cyclophane systems and provides a new access to bio‐friendly NIR‐II photoabsorbers with well‐defined structures.
An Electrochemical Nanosensor for Monitoring the Dynamics of Intracellular H2O2 Upon NADH Treatment
Authors: Zhang Shuai , Qin Hancheng , Cheng Shuwen , Zhang Yue , Gao Nan , Zhang Meining 
Published: February 2023

AbstractReactive oxygen species (ROS)‐based therapeutic strategies play an important role in cancer treatment. However, in situ, real‐time and quantitative analysis of intracellular ROS in cancer treatment for drug screening is still a challenge. Herein we report one selective hydrogen peroxide (H2O2) electrochemical nanosensor, which is prepared by electrodeposition of Prussian blue (PB) and polyethylenedioxythiophene (PEDOT) onto carbon fiber nanoelectrode. With the nanosensor, we find that the level of intracellular H2O2 increases with NADH treatment and that increase is dose‐dependent to the concentration of NADH. High‐dose of NADH (above 10 mM) can induce cell death and intratumoral injection of NADH is validated for inhibiting tumor growth in mice. This study highlights the potential of electrochemical nanosensor for tracking and understanding the role of H2O2 in screening new anticancer drug.
Noncovalent self‐assembled supramolecular aggregate decorated nickel‐aluminum layered double hydroxides nanosheets for reinforcing the flame retardancy of PLA
Authors: Wang Kunyan , Jiang Yuqi , Lv Changjin , Chi Qianhui , Guo Yuhua , Tang Peisong , Pan Guoxiang , Guo Qipeng 
Published: February 2023

AbstractIn this work, an environmentally friendly and energy‐saving strategy to decorate Ni‐Al layered double hydroxides nanosheets (LDHs@PN) has been utilized to boost their flame retardancy and dispersion in the polymer. This proposed strategy was implemented through noncovalent self‐assembly supramolecular aggregate of phytic acid (PA) and 1,4‐bis(3‐aminoethyl) piperazine (AEP) onto NiAl‐LDHs surface in water without any organic solvent. The target product LDHs@PN was investigated by different characterization techniques. It was found that LDHs@PN was successfully fabricated possessing hydrophobic surfaces. In contrast, the surface of LDHs@PN became rough and exhibited a fluffy structure. Meanwhile, Ni, Al, P and N were homogeneously distributed on the surface of LDHs@PN. Significantly, after introducing LDHs@PN into biobased polylactic acid (PLA) via melting‐blending, the thermal stability of composites was improved compared to that of pure PLA and LDHs@PN promotes the formation of composite residual carbon. In addition, the PLA/LDHs@PN composite with 20 wt% loadings reached V‐0 rating in the UL‐94 test and achieved 30.1% limiting oxygen index value, indicating LDHs@PN significantly increased the flame retardant performance of the PLA. The flame retardant mechanism of LDHs@PN in the PLA matrix was analyzed. This facile, low‐cost and eco‐friendly decorating strategy is promising for industrial production.
Rate‐dependent mechanical response of polypropylene nonwovens
Authors: Elamin Mohammed , Pankow Mark 
Published: February 2023

AbstractMost nonwoven products are subjected to a variety of loading rates ranging from low‐speed quasi‐static loads to high‐speed dynamic loads during their life cycles. Understanding their response to a wide range of loading rates is critical to proper usage and effects how rapidly one can process them. In this work quasi‐static to high strain rate experiments (10−3 to 100 to 400 strain/s) are investigated. The results from analyzing the rate‐dependent properties show an increase in the strength and modulus accompanied by a reduced strain to failure in nonwovens as the strain rate increases. Higher basis weight samples showed more prominent rate‐dependent properties across all loading rates and fiber orientations. Ductile to brittle transition in the material failure mechanisms were observed. The specimens with rectangular and circular bonding patterns show higher strain localization than the specimens with the diamond bonding pattern due to the higher fiber reorientation. The rate dependent response at higher loading rates does not follow the typical rate dependent models of Johnson–Cook and Cowper–Symonds. This is a vital understanding as the material greatly stiffens up at higher rates and has a much lower strain to failure than one would expect.
Elevated Levels of Interferon‐α Act Directly on B Cells to Breach Multiple Tolerance Mechanisms Promoting Autoantibody Production
Authors: Ferri Dario M. , Nassar Carol , Manion Kieran P. , Kim Michael , Baglaenko Yuriy , Muñoz‐Grajales Carolina , Wither Joan E. 
Published: February 2023

ObjectiveElevated levels of serum interferon‐α (IFNα) and the disruption of B cell tolerance are central to systemic lupus erythematosus (SLE) immunopathogenesis; however, the relationship between these 2 processes remains unclear. The purpose of this study was to investigate the impact of elevated IFNα levels on B cell tolerance mechanisms in vivo and determine whether any changes observed were due to the direct effect of IFNα on B cells.MethodsTwo classical mouse models of B cell tolerance were used in conjunction with an adenoviral vector encoding IFNα to mimic the sustained elevations of IFNα seen in SLE. The role of B cell IFNα signaling, T cells, and Myd88 signaling was determined using B cell–specific IFNα receptor–knockout, CD4+ T cell–depleted, or Myd88‐knockout mice, respectively. Flow cytometry, enzyme‐linked immunosorbent assay, real‐time quantitative polymerase chain reaction, and cell cultures were used to study the effects of elevated IFNα on the immunologic phenotype.ResultsElevation of serum IFNα disrupts multiple B cell tolerance mechanisms and leads to autoantibody production. This disruption was dependent upon B cell expression of IFNα receptor. Many of the IFNα‐mediated alterations also required the presence of CD4+ T cells as well as Myd88, suggesting that IFNα acts directly on B cells to modify their response to Myd88 signaling and their ability to interact with T cells.ConclusionThe results provide evidence that elevated IFNα levels act directly on B cells to facilitate autoantibody production and further highlight the importance of IFN signaling as a potential therapeutic target in SLE.image
The environment and climate change as a primary stakeholder for accommodation suppliers: Stakeholder engagement for Koh Tao and Koh Phi Phi, Thailand
Authors: Hess Janto S. , Kelman Ilan , Dodds Rachel 
Published: February 2023

AbstractThis study investigates the potential recognition and engagement of the natural environment as an important factor in strategic investment decisions by accommodation suppliers in a small island context. The investigation, based on empirical data from two Thai islands, Koh Tao and Koh Phi Phi, contributes to the debate if the environment, by focusing on climate change, can be identified as a primary stakeholder for accommodation suppliers. The findings show that strategic investment decisions are influenced by impacts commonly associated with climate change, although a conscious recognition of climate change as a strategic stakeholder or important factor in strategic investment decisions could not be confirmed. Conversely, the element of unconsciousness in the process of recognising climate change in investment decisions sparks questions regarding the degree to which the recognition of business stakeholders requires being a conscious process and if the focus on investments could be another element for stakeholder identification frameworks for businesses.
Polystyrene Resins: Versatile and Economical Support for Heterogeneous Nanocatalysts in Sustainable Organic Reactions**
Authors: Sharma Anuj S. , Sharma Vinay S. , Yadav Priyanka , Kaur Harjinder , Varma Rajender S. 
Published: February 2023

AbstractRecent developments in heterogeneous nanocatalysis have illustrated the great strides metal nanoparticles (NPs) have made due to their several significant features. However, the major lingering challenge has been their deactivation in organic reactions by migration‐coalescence largely due to their high surface energy. In this context, various supports materials have been designed to overcome the stability issues for metal NPs. Furthermore, the activity and selectivity could be simultaneously enhanced by taking advantage of the synergy between the metal NPs and the support material, like abundantly available inexpensive polystyrene resins (PSR). Herein, the recent developments on PSR‐supported catalysts are deliberated for assorted organic reactions conducted under sustainable conditions. The salient advantageous attributes of nanocatalyst‐adorned PSR are discussed in terms of their activity, recyclability, stability and selectivity for various organic transformations. Further, the enduring challenges associated with the PSR‐supported nanocatalysts and future perspectives for further developments are explicated.
Mitochondria‐Targeted Gene Silencing Facilitated by Mito‐CPDs
Authors: Lang Wenjie , Tan Wei , Zhou Bizhong , Zhuang Yuli , Zhang Bei , Jiang Linye , Yao Shao Q. , Ge Jingyan 
Published: February 2023

AbstractMitochondrial DNA (mtDNA) plays an essential role in maintaining normal cellular activities. Its heteroplasmic mutations are known to cause various genetic diseases. Current genetic engineering strategies, such as those based on RNA interference (RNAi) and antisense technology, are difficult to genetically alter mtDNA, however, due to the inability of highly negatively charged oligonucleotides to translocate across the double‐membrane mitochondria. We report herein a universal mitochondria‐targeted gene‐delivery approach by using cell‐penetrating poly(disulfide)s (CPDs). Novel CPD‐based mitochondrial transporters, named Mito‐CPDs, were synthesized by using triphenylphosphonium (TPP)‐fused propagating monomers containing either disulfide or diselenide backbones. Upon spontaneous complex formation with an oligonucleotide (single‐ or double‐stranded), the resulting nanoscale Mito‐CPD@Oligo exhibited excellent properties in common biological media. While the intracellular gene‐delivery efficiency of these Mito‐CPDs was comparable to that of commercial transfection agents, their unique mitochondria‐localized properties enabled effective release of the loaded cargo inside these organelles. Subsequent mitochondrial delivery of siRNA and antisense oligonucleotides against suitable mtDNA‐encoded proteins showed successful down‐regulation of target protein expression, leading to profound effects on mitochondrial functions. Mito‐CPDs thus provide a useful tool for future investigations of mitochondrial biology and treatment of mitochondria‐related diseases.
Water‐Induced Single‐Crystal to Single‐Crystal Transformation of Ionic Hydrogen‐Bonded Organic Frameworks with Enhanced Proton Conductivity
Authors: Chen Xu‐Yong , Cao Li‐Hui , Yang Yan , Bai Xiang‐Tian , Zhao Fang , Cao Xiao‐Jie , Huang Ming‐Feng , Gao Yi‐Da , Yang Dan 
Published: February 2023

AbstractTwo ionic hydrogen‐bonded organic frameworks (iHOF‐10, iHOF‐11) were prepared using 1,1′‐diamino‐4,4′‐bipyridine diiodide (Dbpy ⋅ 2I) and tetrakis(4‐sulfophenyl)ethylene (H4TPE). With increasing RH and temperature, water molecules induce single crystal to single crystal (SCSC) transformation of iHOF‐10, resulting in the formation of iHOF‐11. At 90 °C, 98 % RH, the proton conductivity of iHOF‐11 (7.03×10−3 S cm−1) is 2.09 times higher than iHOF‐10 (3.37×10−3 S cm−1). At 50 °C, 98 % RH, iHOF‐11 (9.49×10−4 S cm−1) is 19.06 times higher than iHOF‐10 (4.98×10−5 S cm−1). The proton conductivity shows water molecules enter the crystal and induce crystal transformation and reorganization of the hydrogen bonding structure, thus increasing the proton conductivity and stability.
Tyrosine‐Conjugation Method for Evaluating BACE1 Activity Based on Silver Nanoparticles/Metal–Organic Framework Composites as Electrochemical Tags
Authors: Zhou Yanli , Huang Zihan , Liu Jiaxiang , Dong Hui , Zhang Yintang , Xu Maotian , Bi Yanfeng 
Published: February 2023

AbstractBeta‐site secretase (BACE1) catalyzes the cleavage of amyloid precursor protein (APP), which process ultimately lead to plaque deposition in the brain of Alzheimer's disease (AD). Thus, accurate monitor of BACE1 activity is essential to screen inhibitors for AD treatment. This study develops a sensitive electrochemical assay for probing BACE1 activity based on silver nanoparticles (AgNPs) and tyrosine conjugation as tags and a marking method, respectively. An APP segment is firstly immobilized on aminated microplate reactor. Cytosine (C) rich sequence‐templated AgNPs/Zr‐based metal–organic framework (MOF) composite is modified by phenol groups, and then the prepared tag (ph‐AgNPs@MOF) is captured in microplate surface by the conjugation reaction of phenolic groups between tyrosine and tag. After cleavage by BACE1, the solution containing ph‐AgNPs@MOF tags is transferred to the screen‐printed graphene electrode (SPGE) surface for voltammetric detection of AgNP signal. This sensitive detection for BACE1 provided an excellent linear relationship between 1 to 200 pM with a detection limit of 0.8 pM. Furthermore, this electrochemical assay is successfully applied for screening of BACE1 inhibitors. This strategy is also verified to be used for evaluation of BACE1 in serum samples.
PROTOCOL: An evidence and gap map of studies of implementation issues for interventions for those affected by and at risk of homelessness in high‐income countries
Authors: Singh Sabina , Fitzpatrick Suzanne , Lakshminarayanan Monisha , Saran Ashrita , Wood Jenny , Yang Ting , White Howard 
Published: February 2023

AbstractThis is the protocol for a Campbell systematic review. The objectives are as follows. The proposed evidence and gap map will present relevant process evaluations and other studies of barriers and facilitators, both qualitative and quantitative, for eligible homelessness interventions to highlight the issues arising in the implementation of these interventions. Specifically, the objectives of the map are to: (i) develop a clear taxonomy of interventions and implementation issues (e.g., barriers and facilitators—factors which works as barriers to hinder successful implementation of policies and programmes and factors which facilitate the intervention and therefore support its implementation) related to homelessness in high‐income countries; (ii) map available systematic reviews and primary studies of the implementation issues of interventions for those experiencing homelessness and those at risk of homelessness, with an overview provided in a summary report; (iii) provide a searchable database of included studies accessible to research users via CHI website.
The predictive value of Tp−Te interval, Tp−Te/QT ratio, and QRS‐T angle of idiopathic ventricular tachycardia in patients with ventricular premature beats
Authors: Zhu Wei , Huang Xingmei , Mei Lili , Zhi Liting , Jiang Shili , Jin Jianling , Zou Cao 
Published: February 2023

AbstractBackgroundIdentify idiopathic ventricular tachycardia in patients with ventricular premature beats was required to have effectively treatment.HypothesisThe aim of this study is to investigate the predictive value of Tp−Te interval, Tp−Te/QT ratio, and QRS‐T angle of idiopathic ventricular tachycardia in patients with idiopathic ventricular premature beats.MethodsOne hundred and seventy‐eight patients who had undergone premature ventricular complex/ventricular tachycardia (PVC/VT) ablation between January 1, 2020 and August 30, 2022 constituted our study population as ventricular arrhythmia group. Seventy‐five healthy people were selected as control group. Patients with no episode of VT were classified as PVC group, while with any episode of VT that has the same morphology with PVC were classified as PVC with VT group. Patients in PVC with VT group were divided into two groups: nonsustained VT group (duration of any episode of VT below 30 s) and sustained VT group (duration of any episode of VT over 30 s). Tp–Te interval, Tp–Te/QT ratio and QRS‐T angle were compared in groups.ResultsTp–Te interval, Tp–Te/QT ratio and patients with increased QRS‐T angle in PVC with VT group were higher or more than those in PVC group (p < .001). The value of combined diagnosis of these indexes was higher. Tp–Te interval was longer in the sustained VT group compared to the nonsustained VT group (p = .009).ConclusionTp–Te interval, Tp–Te/QT ratio, and QRS‐T angle may have a predictive value of presence of idiopathic VT in patients with premature beats and the combined prediction of these indexes is more valuable. Tp–Te interval maybe helpful for prediction of sustained idiopathic VT.
Ethnic disparities in childhood leukemia survival by border residence: A Texas population‐based analysis
Authors: Castellanos Maria I. , Oluyomi Abiodun O. , Chambers Tiffany M. , Gramatges Maria M. , Winestone Lena E. , Lupo Philip J. , Scheurer Michael E. 
Published: February 2023

AbstractBackgroundThe US–Mexico border is a medically underserved region where survival disparities have been observed in adults diagnosed and treated for various malignancies. Studies examining survival disparities among children living in this region and diagnosed with cancer are lacking. The objective of this study was to evaluate the impact of border residence on survival among children with acute lymphoblastic leukemia (ALL), acute myeloid leukemia (AML), and living near the Texas–Mexico border at the time of their diagnosis. The authors hypothesized that this group experiences inferior survival compared with patients with childhood leukemia living in nonborder areas.MethodsThe authors conducted a retrospective survival analysis leveraging data from the Texas Cancer Registry. The study included patients aged birth to 19 years who were diagnosed with ALL or AML between 1995 and 2017. Cox proportional hazards models were used to evaluate the factors associated with the risk of death. Overall survival estimates were calculated using Kaplan–Meier methods.ResultsDuring the study period, there were 6002 children diagnosed with ALL and 1279 diagnosed with AML. Inferior 5‐year overall survival was observed among children with ALL living along the border region compared with those living in nonborder areas (77.5% vs. 85.8%). In adjusted models, children with ALL living along the border experienced a 30% increased hazard of death versus children living in nonborder areas. In contrast, for children with AML, survival estimates did not vary by border versus nonborder residence.ConclusionsLiving along the border was associated with inferior survival among children with ALL, but not among children with AML. Additional studies are urgently needed to identify the factors driving these disparities to effectively design multilevel interventions and influence state and national cancer control programs.