bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stress-related reduction of hippocampal subfield volumes in major depressive disorder: A 7-Tesla study
Authors: Alper Judy , Feng Rui , Verma Gaurav , Rutter Sarah , Huang Kuang-han , Xie Long , Yushkevich Paul , Jacob Yael , Brown Stephanie , Kautz Marin , Schneider Molly , Lin Hung-Mo , Fleysher Lazar , Delman Bradley N. , Hof Patrick R. , Murrough James W. , Balchandani Priti 
Published: February 2023

BackgroundMajor depressive disorder (MDD) is a prevalent health problem with complex pathophysiology that is not clearly understood. Prior work has implicated the hippocampus in MDD, but how hippocampal subfields influence or are affected by MDD requires further characterization with high-resolution data. This will help ascertain the accuracy and reproducibility of previous subfield findings in depression as well as correlate subfield volumes with MDD symptom scores. The objective of this study was to assess volumetric differences in hippocampal subfields between MDD patients globally and healthy controls (HC) as well as between a subset of treatment-resistant depression (TRD) patients and HC using automatic segmentation of hippocampal subfields (ASHS) software and ultra-high field MRI.MethodsThirty-five MDD patients and 28 HC underwent imaging using 7-Tesla MRI. ASHS software was applied to the imaging data to perform automated hippocampal segmentation and provide volumetrics for analysis. An exploratory analysis was also performed on associations between symptom scores for diagnostic testing and hippocampal subfield volumes.ResultsCompared to HC, MDD and TRD patients showed reduced right-hemisphere CA2/3 subfield volume (p = 0.01, η2 = 0.31 and p = 0.3, η2 = 0.44, respectively). Additionally, negative associations were found between subfield volumes and life-stressor checklist scores, including left CA1 (p = 0.041, f2 = 0.419), left CA4/DG (p = 0.010, f2 = 0.584), right subiculum total (p = 0.038, f2 = 0.354), left hippocampus total (p = 0.015, f2 = 0.134), and right hippocampus total (p = 0.034, f2 = 0.110). Caution should be exercised in interpreting these results due to the small sample size and low power.ConclusionDetermining biomarkers for MDD and TRD pathophysiology through segmentation on high-resolution MRI data and understanding the effects of stress on these regions can enable better assessment of biological response to treatment selection and may elucidate the underlying mechanisms of depression.
Prevalence of neuropsychiatric disorders in patients with systemic lupus erythematosus in Pakistan: A systematic review and meta-analysis
Authors: Khan Muhammad Imran , Qureshi Humera , Akhtar Sohail , Bae Suk Joo , Hassan Fazal 
Published: February 2023

IntroductionBy conducting a systematic review and meta-analysis, we investigated the prevalence of neuropsychiatric (NP) symptoms among systemic lupus erythematosus (SLE) patients in Pakistan.MethodsIn this review work, three electronic databases (Web of Science, MEDLINE, and Google Scholar) and local databases were screened for 20 years from 1 January 2002 to 30 September 2022, to identify the articles evaluating the prevalence of NP symptoms in SLE patients in Pakistan. We performed a random-effects meta-analysis to estimate the prevalence of NPSLE. Statistical heterogeneity was measured by the I2 index, and subgroup meta-analyses were used to access the statistical heterogeneity. Furthermore, meta-regression models were used to examine the associations between prevalence estimates and study characteristics of interest. Three independent authors reviewed existing studies, extracted data, and rated the qualities of selected studies. This review was registered on PROSPERO (Registration no. CRD42022361798).ResultsThirteen studies met the inclusion criteria out of the 322 studies with a total of 2,003 SLE patients for this systematic review and meta-analysis. The prevalence of NP disorders in SLE patients was estimated to be 30.42% (95% CI:18.26–44.11%), with cognitive dysfunction being the most common (31.51%; 95% CI:1.28–76.27%), followed by headache (10.22%; 95% CI: 0.00–33.43%), seizures (5.96%; 95% CI: 3.80–8.53%), psychosis (3.64%; 95% CI: 2.38–5.13%), and neuropathy is the least common (0.86%; 95% CI: 0.00–2.74%). The heterogeneity between studies was significant (p &lt; 0.01). The pooled prevalence of NP disorders among SLE patients was found highest in Punjab (41.21%) and lowest in Sindh (17.60%).ConclusionFindings from this study revealed that SLE patients have a high prevalence of NP disorders. The most common symptoms were cognitive dysfunctions, headaches, seizures, psychosis, and neuropathy. Clinicians can manage these potentially deadly and disabling diseases more effectively if they understand the incidence of each NP symptom in SLE patients. NP symptoms among SLE patients are at their peak in Pakistan; policymakers should devise preventive strategies to curb the disease.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record. php?RecordID=361798, identifier CRD42022361798.
Idealistic, realistic, and unrealistic expectations of pharmacological treatment in persons with type 2 diabetes in primary care
Authors: Salinas Martínez Ana María , Juárez Montes Angélica Gabriela , Ramírez Morado Yesenia , Cordero Franco Hid Felizardo , Guzmán de la Garza Francisco Javier , Hernández Oyervides Luis Carlos , Núñez Rocha Georgina Mayela 
Published: February 2023

IntroductionInformation on treatment expectations in diabetes is scarce for Mexican and Latino populations. We determined idealistic, realistic, and unrealistic expectations for metformin, insulin, and glyburide in primary care. We also explored the association between sociodemographic attributes, time since diagnosis, and expectations.MethodsThis was a cross-sectional study conducted during 2020–2022 in governmental primary care centers. We consecutively included persons with type 2 diabetes aged 30–70 years under pharmacological medication (n = 907). Questions were developed using information relevant to expectation constructs. Data were collected by interview. We used descriptive statistics, a test of the difference between two proportions, and multivariate ordinal logistic regression.ResultsA high percentage of participants would like to have fewer daily pills/injections or the option of temporarily stopping their medication. Realistic expectations ranged from 47% to 70%, and unrealistic expectations from 31 to 65%. More insulin users wished they could take a temporary break (p &lt; 0.05) or would like to be able to change the route of administration (p &lt; 0.001) than metformin users. More persons with diabetes on insulin expected realistic expectations compared to those on metformin or glyburide (p ≤ 0.01). Being able to interrupt medication upon reaching the glucose goal was higher in combined therapy users (p &lt; 0.001).ConclusionTime since diagnosis, place of residence, sex, and diabetes education were factors associated to expectations. Management of expectations must be reinforced in primary care persons with type 2 diabetes undergoing pharmacological medication.
Acute phase proteins levels in horses, after a single carbohydrate overload, associated with cecal alkalinization
Authors: Peixoto Rabelo Isabela , Barroco de Paula Vanessa , Carvalho Bustamante Caio , Santana André Marcos , Gomes da Silva Daniela , Baldassi Amanda Cristina , Canola Paulo Aléscio , Araújo Valadão Carlos Augusto 
Published: February 2023

IntroductionHorses submitted to carbohydrate overload can develop laminitis due to changes in cecal pH and microbiota, followed by an increase in transmural absorption of luminal content, including bacterial toxins. In response to acute injury there is hepatic overproduction of several proteins known as acute phase proteins (APP). Few studies have evaluated protein fractionation to characterize the inflammatory response in acute laminitis. The aim of this study was to test the viability of an experimental model to induce acute laminitis, using a single carbohydrate overload, and the influence of a buffering solution on the development of the disease; also, study the kinetics of APP during acute laminitis, as well as the correlation between these proteins and clinical signs associated to this syndrome.MethodsTen healthy horses were divided in a factorial and randomized way into four groups (n= 5): control group (CG), starch group (SG), buffer group (BG), and starch C buffer group (SBG). They were evaluated at seven times (T0h, T4h, T8h, T12h, T24h, T48h, and T72h), which included clinical evaluation and blood sample collection. Total serum protein and albumin concentrations were determined by colorimetry and the other APP by polyacrylamide gel electrophoresis containing sodium dodecyl sulfate and commercial ELISA kits. Data were analyzed by two-way ANOVA, followed by Tukey's test (p&lt; 0.05). The correlation between clinical signs and APP were verified using the Pearson's correlation coefficient.Results and discussion40% of the animals from SG and 60% from SBG developed clinical laminitis. A single administration of buffer solution was not able to prevent clinical signs of laminitis. There was no difference between groups on total serum protein, albumin, serum amyloid A and C-reactive protein concentrations (p&gt; 0.05). Transferrin, considered a negative APP, showed a positive response pattern in SG and SBG. Ceruloplasmin had a positive correlation with Obel grade, heart rate on animals from SGB and number of steps on horses submitted to starch overload (SG and SBG). Ceruloplasmin, α-1-antitrypsin and haptoglobin concentrations increased in SBG, suggesting an inflammatory response in animals of this group. Changes in clinical parameters were also more evident in the SBG, corroborating the protein fractionation findings.
Evaluación e intervención paliativa del dolor mixto en las personas con síndrome demencial avanzado
Authors: Maroto-Martínez Melania , Acuña-Aguilar Carlos , Roselló-Araya Marlene 
Published: February 2023

Objetivos: establecer la evaluación e intervención paliativa del dolor mixto en las personas con síndrome demencial avanzado, mediante el análisis de las escalas validadas e identificando las medidas farmacológicas y no farmacológicas basadas en estas escalas. Metodología: estudio descriptivo tipo revisión narrativa. La extracción de datos se obtuvo por medio de una revisión exhaustiva de artículos científicos seleccionados según el nivel de evidencia. Se utilizaron los motores de búsqueda Pubmed, Cochrane Library, Scielo, ELSEVIER, Revista Médica Británica, Biomed Central-Editorial científica británica. Se incluyeron artículos que relacionaran los temas de personas adultas con síndrome demencial y síndrome demencial avanzado y dolor, publicados en inglés y español, entre el 2006 y el 2022. Se excluyeron artículos que trataran de personas menores de edad con déficits cognitivos y de adultos con dolor mixto sin déficits cognitivos. Se utilizaron los siguientes descriptores: pain AND dementia, palliative care AND advanced dementia, dementia OR severe cognitive impairment, pain assessment AND scales. Se incluyen 26 artículos, entre los cuales se encontraron estudios de metaanálisis y revisión sistemática de ensayos clínicos aleatorizados para un 38,4%; revisión sistemática con homogeneidad de estudios de cohortes un 11,5%; estudios observacionales analíticos de cohortes y estudios observacionales descriptivos un 38,4%, y revisiones narrativas un 11,5%. Resultados y conclusiones: se determinó que las escalas validadas para la evaluación del dolor mixto en personas con síndrome demencial avanzado son principalmente PAINAD-Sp, escala de Abbey, MOBID-2, Mahoney, PADE y PACSLAC-2. Respecto a los tratamientos farmacológicos, el paracetamol, opioides, antiinflamatorios no esteroideos y neuromoduladores son los más usados. En las terapias no farmacológicas se recomienda la musicoterapia, sin embargo, las pruebas son escazas. En general, la evidencia debe seguir desarrollándose, a fin de que los futuros estudios clínicos se lleven a cabo con muestras más grandes y homogéneas.
La espiritualidad desde la mirada de Terapia Ocupacional en el contexto de los Cuidados Paliativos
Authors: Mondelo Carla 
Published: February 2023

Los Cuidados Paliativos, al igual que la Terapia Ocupacional, proponen una mirada holística de la persona, incluyendo las dimensiones: física, emocional, social y espiritual. La espiritualidad se encuentra íntimamente unida a la participación en ocupaciones significativas. La ocupación se convierte en un medio para la expresión de ésta. En el artículo se efectúa un recorrido por el concepto de espiritualidad y la intervención desde la Terapia Ocupacional. La evidencia de las necesidades espirituales no atendidas manifiesta una limitación en la atención integral de los equipos en Cuidados Paliativos. Se exponen seis cualidades esenciales para la atención de la espiritualidad en los profesionales de la salud que pueden ser tenidas en cuenta desde un modelo paliativo centrado en la persona. Asimismo, se propone un enfoque de atención centrado en la persona y en la ocupación. De este modo, se pretende exponer la importancia de la espiritualidad, como un determinante para la salud y el bienestar de las personas, y un modo de expresión a partir de la participación en ocupaciones significativas, favoreciendo el afrontamiento y la adaptación a la situación de enfermedad en personas y familias que asisten a Cuidados Paliativos.
Efecto de la edad sobre la velocidad de la onda de pulso y el deterioro cognitivo
Authors: Morales-Matamoros Orlando 
Published: February 2023

La población adulta mayor en el mundo ha ido en aumento con los años y en el caso de Costa Rica, pasó del 5% en el año 2000 al 10% en el año 2020; con ello mayor número de enfermedades asociadas al envejecimiento son evidentes, entre ellas las patologías demenciales. Una alternativa de valoración del deterioro cognitivo es la medición de la velocidad de la onda de pulso (VOP). Muchos factores alteran este parámetro: la edad, hipertensión, diabetes o enfermedades cardiacas. Sin embargo, los estudios de investigación y las revisiones de metaanálisis relacionan la VOP con desórdenes cognitivos asociados con el envejecimiento. Aunque esta no es una prueba diagnóstica definitiva, es importante seguir sus cambios en el tiempo y de esta forma determinar correlaciones con el estado cognitivo de los pacientes. La relación entre la VOP y el deterioro cognitivo todavía requiere investigación, pero hasta el momento es claro que es un factor asociado con la declinación de habilidades mentales o estados demenciales en personas adultas mayores. Sin embargo, debe tomarse en cuenta que otros factores de origen genéticos y estilos de vida pueden estar involucrados. Debido a que la medición de la VOP es una sencilla prueba no invasiva a través de equipo de medición clínica sencillo, es conveniente que las instituciones que tratan pacientes de edad avanzada realicen mediciones rutinarias y sistemáticas de este parámetro. Esto permitiría conocer un factor asociado a la condición cognitiva del paciente, la evolución del padecimiento o los beneficios terapéuticos de sus tratamientos.
Saberes tradicionais e Educação Ambiental no Brasil: possibilidades e desafios
Authors: Carvalho Frederico Mendes de 
Published: February 2023

Este texto, construído a partir de uma entrevista com a makota Cássia Kidoialê, relevante liderança da Comunidade Kilombola Manzo Ngunzo Kaiango, situada na periferia de Belo Horizonte, no bairro Santa Efigênia - que milita na valorização dos saberes tradicionais e a importância de se considerar tais conhecimentos na articulação das diversas políticas públicas - reflete sobre as possibilidades e desafios presentes na necessária articulação entre os saberes tradicionais e a ciência ocidental no processo de Educação Ambiental. O artigo é composto por três partes e na primeira farei uma breve conceituação de Educação Ambiental e os marcos legais que a constituíram no Brasil e no mundo. Na segunda, discutirei o apagamento histórico dos saberes tradicionais e sua desconsideração na construção da Educação Ambiental e por fim, apontarei possibilidades de articulação dos saberes afro-brasileiros e indígenas com a Educação Ambiental na constituição de um modelo diverso, inclusivo e amplo. O texto traz pistas de como se implementar a Educação Ambiental incorporando saberes dos povos afro-brasileiros e indígenas, e o quanto isso é importante para a cidadania, uma vez que reitera o caráter multiétnico, complexo e plural presente na formação da sociedade brasileira contemporânea.
VALIDITAS PERANGKAT PEMBELAJARAN BERBASIS STEAM MATERI STRUKTUR DAN FUNGSI JARINGAN TUMBUHAN UNTUK MENINGKATKAN PENGUASAAN KONSEP
Authors: Sabara Anita , Yusuf Frida Maryati , Ahmad Jusna 
Published: February 2023

Penelitian ini adalah Penelitian pengembangan yang bertujuan untuk mendeskripsikan validitas perangkat pembelajaran berbasis STEAM berupa RPP, LKPD dan Tes Penguasaan konsep pada materi struktur dan fungsi jaringan pada tumbuhan di SMPN 1 Kwandang dan SMPN 2 Kwandang. Hasil penelitian menunjukkan kualitas produk yang dihasilkan berdasarkan kevalidan RPP memenuhi kriteria sangat valid dengan nilai rata-rata dari validator 96 % , LKPD memenuhi kriteria sangat valid dengan nilai rata-rata dari validator 97 % dan tes penguasaan konsep memenuhi kriteria sangat valid dengan nilai rata-rata 97 %. Berdasarkan hasil penelitian dapat disimpulkan bahwa perangkat pembelajaran berbasis STEAM pada materi struktur dan fungsi jaringan pada tumbuhan memenuhi kriteria valid untuk meningkatkan penguasaan konsep peserta didik
UJI VALIDITAS PERANGKAT PEMBELAJARAN MODEL KETERPADUAN TIPE CONNECTED BERORIENTASI STUDI KASUS PADA MATERI PENCEMARAN LINGKUNGAN UNTUK MENUNJUKKAN KEMAMPUAN BERPIKIR PESERTA DIDIK
Authors: Maruni Mulyadi , Latjompoh Masra , Yusuf Frida Maryati 
Published: February 2023

Penelitian ini adalah Penelitian pengembangan yang bertujuan untuk mendeskripsikan validitas perangkat pembelajaran model keterpaduan tipe connected berorientasi studi kasus sehingga dapat digunakan dalam proses pembelajaran untuk menunjukkan kemampuan berpikir peserta didik. Penelitian pengembangan ini dirancang dengan mengikuti tahap-tahap model pengembangan Research Development dengan rancangan uji coba One-Group Pretest-Posttest Design. Hasil penelitian menunjukkan kualitas produk yang dihasilkan berdasarkan kevalidan RPP memenuhi kriteria sangat valid dengan nilai rata-rata dari validator sebesar 89,02%, LKPD memenuhi kriteria sangat valid dari validator dengan rata-rata nilai sebesar 87,76% dan THB (Tes Hasil Belajar) memenuhi kriteria sangat valid dengan nilai rata-rata sebesar 90%. Berdasarkan hasil penelitian dapat disimpulkan bahwa perangkat pembelajaran model keterpaduan tipe connected berorientasi studi kasus pada materi pencemaran lingkungan memenuhi kritera sangat valid untuk menunjukkan kemampuan berpikir peserta didik dan dapat digunakan dalam proses pembelajaran
UJI VALIDITAS PENGEMBANGAN PERANGKAT PEMBELAJARAN MENGGUNAKAN MODEL PEMBELAJARAN PROBLEM SOLVING MATERI PEWARISAN SIFAT UNTUK MELATIH KETERAMPILAN BERPIKIR KRITIS
Authors: Latif Dahlan , Yusuf Frida Maryati , Dama Lilan 
Published: February 2023

Penelitian ini adalah Penelitian pengembangan yang bertujuan untuk mendeskripsikan validitas perangkat pembelajaran menggunakan model pembelajaran problem solving berupa RPP, LKPD dan Tes Berpikir Kritis menggunakan model pembelajaran problem solving materi pewarisan sifat di SMPN 3 Satu Atap Tilamuta. Hasil penelitian menunjukkan kualitas produk yang dihasilkan berdasarkan kevalidan RPP memenuhi kriteria sangat valid dan valid dengan nilai rata-rata dari validator berkisar antara 80 sampai dengan 100%, LKPD memenuhi kriteria sangat valid dan valid dari validator berkisar antara 80 sampai dengan 100% dan tes berpikir kritis memenuhi kriteria sangat valid dan valid dengan nilai rata-rata berkisar antara 80 sampai dengan 100%. Berdasarkan hasil penelitian dapat disimpulkan bahwa perangkat pembelajaran menggunakan model pembelajaran problem solving materi pewarisan sifat memenuhi kriteria valid untuk melatih keterampilan berpikir kritis peserta didik
Feminización de las prácticas de cuidados en discapacidad.
Authors: Furno Laura Yamile , Roncoli Verónica Celeste , Agüero Mirian Leticia 
Published: February 2023

En el presente trabajo reflexionamos sobre las prácticas de cuidados que se brindan a personas con discapacidad usuarias del Instituto Nacional de Rehabilitación Psicofísica del Sur Dr. Juan O. Tesone. Las analizamos desde una perspectiva situada, en clave de complejidad, interpelándolas como actividades del ámbito público, no sólo reservadas al espacio privado-familiar. Las mismas son desempeñadas en su mayoría por mujeres del núcleo familiar -rol históricamente naturalizado e invisibilizado- cuyo entramado requiere de miradas intersectoriales, problematizando también la responsabilidad de toda la sociedad y el Estado. Invitamos a desnaturalizar el cuidado como lo propio de las mujeres, teniendo en cuenta que las personas en situación de discapacidad requieren cuidados complejos y de larga data. Realizamos un análisis cuali cuantitativo de las prácticas de cuidado en la población que recibe atención en dicho instituto bajo las modalidades de internación y rehabilitación en domicilio. Consideramos necesario reflexionar sobre el rol que tenemos les profesionales de equipos de salud en rehabilitación, la sociedad y el Estado para que el sistema de cuidados sea un derecho en plena vigencia.
Defect suppression of a perovskite film with In2O3 quantum dots for improved solar cell performance
Authors: Zhou Dianli , Yang Genjie , Li Jiawen , Pan Jun 
Published: February 2023

Abstract
Solution-processable indium oxide quantum dots (In2O3) were introduced into a MAPbI3 film to solve the problem of low MAPbI3 film quality caused by inherent defects. Compared with the MAPbI3 film, the MAPbI3:In2O3 film exhibited an optimized time-resolved photoluminescence component ratio and improved carrier dissociation and transport efficiency. When the MAPbI3:In2O3 film was used to fabricate solar cells instead of the MAPbI3 film, the fill factor enhanced from 76.32% to 80.63%, the short circuit current density increased from 20.18 mA cm−2 to 21.32 mA cm−2, and the power conversion efficiency improved from 13.96% to 16.18% in the standard AM 1.5 illuminated condition, respectively.
EKSPLORASI TEKNIK LEKAPAN PADA BUSANA PESTA DENGAN SUMBER IDE RUMAH BOLON DAN BUNGA ANGGREK TIEN
Authors: Bella Dita , Wiana Winwin 
Published: February 2023

Indonesia is known as a country with abundant wealth, including the wealth of traditional houses and flora. Traditional houses and flora are part of the natural wealth and culture of Indonesia, including a system of tools and living equipment and technology. The traditional house of Bolon is a work of cultural heritage that still exists today, as a residence for kings and has a philosophy and noble meaning contained in every corner of the building. Tien orchid (Cymbidium hartinahianium) is an endemic plant of North Sumatera,which lives in groups and was first discovered in 1976. As a source of archipelago ideas from the North Sumatera region, the traditional house of Bolon and the Tien Orchid flower can represent a symbol of the natural and cultural wealth of the people of North Sumatera, is one of the largest provinces in Indonesia. The curved design of the party dress that will be made is inspired by the shape of Bolon traditional house and Tien Orchid flower. The materials used for the curls are Ulos Sadum woven cloth, embroidery threand, pearls, and organza ribbon flowers. The method used is Project Based Learning (PBL). The result of this exploration study are aimed at preserving Indonesia’s natural and cultural wealth which is starting to become extinct and forgetten, through making a amatching and beautiful party dress.

Key words: Lekapan technique, Rumah Bolon, Tien Orchid