bluuebunny/crossref_metadata_2025_split huggingface dataset:
Is sacral neuromodulation effective and safe in pregnancy? A systematic review
Authors: Salehi‐Pourmehr Hanieh , Atayi Morteza , Mahdavi Nasim , Aletaha Reza , Kashtkar Mahsa , Sharifimoghadam Soroush , Hassanzadeh Robab , Hajebrahimi Sakineh 
Published: June 2023

AbstractObjectiveWe systematically assessed all available evidence on the efficacy and safety of sacral neuromodulation (SNM) in pregnancy.MethodsOn September 2022, a thorough search was done on Ovid, PubMed, Scopus, ProQuest, Web of Science, and The Cochrane Library. We chose studies that included pregnant women who had SNM previously. Two authors independently evaluated the quality of the study using a standardized tool of JBI. Studies were given a risk of bias rating of low, moderate, or high. Given the descriptive nature of this study, we utilized descriptive statistics to report demographic and clinical features. For continuous variables, we used mean and standard deviation, and for dichotomous data, we used frequencies and percentages.ResultsOut of 991 abstracts screened, only 14 studies met our inclusion criteria and were included in the review. Overall, the quality of the evidence available from the literature is low based on the design of the included studies. Fifty‐eight women, including 72 pregnancies, had SNM. The indication of SNM implantation was filling phase disorders in 18 cases (30.5%), voiding dysfunction in 35 women (59.3%), IC/BPS in two cases (3.5%), and fecal incontinence. In 38 pregnancies (58.5%), the SNM status was ON during pregnancy. Forty‐nine cases delivered a full‐term baby (75.4%), 12 cases had pre‐term labor (18.5%), two miscarriages, and two postterm pregnancies happened. The most complications in patients with devices were urinary tract infection in 15 women (23.8%), urinary retention in six patients (9.5%), and pyelonephritis in two cases (3.2%). The findings revealed that when the device was deactivated, 11 cases out of the 23 patients (47.8%) had full‐term pregnancies, while in ON status, 35 out of the 38 pregnant women (92.1%) had full‐term pregnancies. Nine preterm labors in OFF (39.1%), and two in ON status (5.3%) were recorded. The results revealed that this difference was statistically significant (p = 0.002), and those who turned SNM of them off had more preterm labor. Although the studies reported all neonates had a healthy status, two children had chronic motor tic problems and a pilonidal sinus in a case with an active SNM in pregnancy. However, there was no association between the SNM status and pregnancy or neonatal complications (p = 0.057).ConclusionSNM activation in pregnancy seems safe and effective. The choice of whether to activate or deactivate SNM should be made on an individual basis given the current SNM evidence.
A novel whale optimization smith predictor based on feedforward compensation for controlling wave rotor refrigeration process
Authors: Li Qi , Yang Menghan , Ba Wei , Wang Fan , Hu Xiaopeng 
Published: June 2023

AbstractAiming at the difficulty of temperature control and disturbance rejection control in wave rotor refrigeration process (WRRP), a novel whale optimization two‐degree‐of‐freedom (2DOF) Smith predictor based on feedforward compensation method (WO‐2DOFSP‐FC) is proposed. Firstly, the obtained test data of the WRRP are used for system identification and the approximate second‐order model with time‐delay is obtained by using the suboptimal reduction algorithm. This procedure also yields a first‐order model of the disturbance. Then, the whale optimization 2DOF Smith predictor based on feedforward compensation (2DOFSP‐FC) method is proposed. This proposed method improves the 2DOFSP and introduces feedforward compensation control to reduce the influence of the measurable disturbance on the temperature control system. In addition, the Whale Optimization Algorithm (WOA) is proposed to optimally tune the 2DOFSP‐FC controller parameters. Finally, the simulation results show that the proposed WO‐2DOFSP‐FC method can make the controlled system have good characteristics of both set value tracking and disturbance rejection.
Elective Neck Dissection for cT1‐4 N0M0 Head and Neck Verrucous Carcinoma
Authors: Patel Aman M. , Vedula Sudeepti , Haleem Afash , Choudhry Hassaam S. , Tseng Christopher C. , Park Richard Chan Woo 
Published: June 2023

AbstractObjectiveTo investigate the survival benefit of elective neck dissection (END) over neck observation in cT1‐4 N0M0 head and neck verrucous carcinoma (HNVC).Study DesignRetrospective cohort study.SettingThe 2006 to 2017 National Cancer Database.MethodsPatients with surgically resected cT1‐4 N0M0 HNVC were selected. Linear, binary logistic, Kaplan‐Meier, and Cox proportional hazards regression models were utilized.ResultsOf 1015 patients satisfying inclusion criteria, 223 (22.0%) underwent END. The majority of patients were male (55.4%) and white (91.0%) with disease of the oral cavity (67.6%) classified as low grade (90.0%) and cT1‐2 (81.8%). The minority of ENDs (4.0%) detected occult nodal metastases. The rate of END increased from 2006 to 2017 for both cT1‐2 (16.3% vs 22.0%, p = .126, R2 = 0.405) and cT3‐4 (41.7% vs 70.0%, p = .424, R2 = 0.232) disease but these trends were not statistically significant. Independent predictors of undergoing END included treatment at an academic facility (adjusted odds ratio [aOR]: 1.75, 95% confidence interval [CI]: 1.19‐2.55), cT3‐4 disease (aOR: 3.31, 95% CI: 2.16‐5.07), and tumor diameter (aOR: 1.09, 95% CI: 1.01‐1.19) (p < 0.05). The 5‐year overall survival (OS) of patients treated with and without END was 71.3% and 70.6%, respectively (p = .661). END did not significantly reduce the 5‐year hazard of death (adjusted hazard ratio: 1.25, 95% CI: 0.91‐1.71, p = .172). END did not significantly improve 5‐year OS in univariate and multivariate analyses stratified by several patient, facility, tumor, and treatment characteristics.ConclusionEND does not confer an appreciable survival benefit in HNVC, even after stratifying univariate and multivariate analyses by several patient, facility, tumor, and treatment characteristics.Level of EvidenceLevel 4.
Is fat‐free mass‐based gentamicin dosing regimen preferable than whole‐body weight in neonates?
Authors: Sridharan Kannan , Al Jufairi Muna , Al Ansari Eman , Alsadah Lulwa , Wasel Howra 
Published: June 2023

ABSTRACTImportanceBody fluid dynamics and renal maturation status vary during the neonatal period. We hypothesized that differences in peak and trough gentamicin concentrations could be expected.ObjectiveTo predict the peak and trough gentamicin concentrations in critically ill neonates and to predict the changes in the predicted peak plasma concentrations of gentamicin following fat‐free mass dosing.MethodsCritically ill neonates that received gentamicin and have gentamicin concentration measured were recruited. Fat mass was estimated using skinfold thicknesses. Changes in the peak plasma concentrations (Cmax) using whole‐body weight (estimated using the current dosing regimen) and predicted concentrations following the fat‐free mass‐based dosing were the outcome measures.ResultsEighty‐nine critically ill neonates were recruited. Sub‐therapeutic Cmax was estimated using the current dosing regimen in 32.6%, and 22.5% neonates following the first and second doses of gentamicin. Preterm neonates had significantly higher fat mass compared to term neonates. All except one had Cmax above 12 μg/ml after the first dose and all had after the second gentamicin dose following the predicted fat‐free mass‐based gentamicin dosing. The recommended doses are as follows: extreme preterm: 7.95 mg/kg every 48 h; very preterm: 7.30 mg/kg every 36–48 h; late preterm: 5.90 mg/kg every 36–48 h; and term neonates at 5.10 mg/kg every 24 h.InterpretationFat‐free mass dosing may be considered for obtaining optimal therapeutic effects in the neonatal population.
Potential application of spectral indices for olive water status assessment in (semi‐)arid regions: A case study in Khuzestan Province, Iran
Authors: Asgari Azimeh , Hooshmand Abdolrahim , Broumand‐Nasab Saeed , Zivdar Shohreh 
Published: June 2023

AbstractSpectral indices can be used as fast and non‐destructive indicators of plant water status or stress. It is the objective of the present study to evaluate the feasibility of using several spectral indices including water index (WI) and normalized spectral water indices 1–5 (NWI 1–5) to estimate water status in olive trees in arid regions in Iran. The experimental treatments involved two olive cultivars (Koroneiki and T2) and four irrigation regimes (irrigated with 100%, 85%, 70%, and 55% estimated crop evapotranspiration [ETc]). The results obtained showed that olive trees subjected to the different irrigation regimes of 85%, 70%, and 55% ETc experienced soil water content (SWC) deficits by 4.5%, 12%, and 20.5% that of the control, respectively. Significant differences were observed among the treatments with respect to measured relative water content (RWC), SWC, and the spectral indices of WI and NWI 1–5. The normalized spectral indices combining NIR and NIR wavelengths were found more effective in tracking changes in RWC and SWC than those that combine NIR and VIS or VIS and VIS wavelengths, respectively. Spectral indices were closely and significantly associated with RWC () and SWC (). Among all the spectral indices investigated, NWI‐2 showed the least consistent associations with RWC (ranging from 4–15% lower than the other indices examined) and SWC (ranging from 1–23% lower than the others). Based on the pooled data on spectral indices, RWC, and SWC collected during the study period, WI, NWI‐1, NWI‐4, and NWI‐5 showed stronger correlations with RWC and SWC than did NWI‐3 and NWI‐2. In conclusion, the spectral indices of WI and NWI 1–5 measured at the leaf level are found useful as fast and non‐destructive estimators of plant water stress in arid regions.
Caring for dependent children impacts practical and emotional problems and need for support, but not perceived distress among cancer patients
Authors: Fugmann Dominik , Richter Peter , Karger André , Ernstmann Nicole , Hönig Klaus , Bergelt Corinna , Faller Hermann , Maatouk Imad , Hornemann Beate , Stein Barbara , Teufel Martin , Goerling Ute , Erim Yesim , Geiser Franziska , Albus Christian , Senf Bianca , Wickert Martin , Weis Joachim 
Published: June 2023

AbstractObjectiveMore than one in 10 cancer patients care for dependent children. It is unclear whether this status makes a difference in terms of the distress and associated problems they experience, or whether it is linked to differences in the need for or utilization of psychosocial support.MethodsSecondary analysis of a cross‐sectional German study in National Comprehensive Cancer Centers using self‐report standardized questionnaires administered to inpatients. Patients living with dependent children (n = 161) were matched by age and sex with a subsample of 161 cancer patients not living with dependent children. The resulting sample was tested for between‐group differences in Distress Thermometer (DT) scores and the corresponding DT Problem List. Additionally, between‐group differences in measures of the need for and utilization of psychosocial support were examined.ResultsMore than 50% of all patients suffered from clinically relevant distress. Patients living with dependent children reported significantly more practical (p < 0.001, η2p = 0.04), family (p < 0.001, η2p = 0.03), and emotional problems (p < 0.001, η2p = 0.01). Although reporting a greater need for psychological support, parents with cancer were not found to more frequently utilize any type of psychosocial support.ConclusionsThe specific problems and needs of parents with cancer who care for dependent children are currently not sufficiently addressed in the clinical care pathways. All families should be helped to establish open and honest communication as well as understand the available support systems and what they can provide. Tailored interventions should be implemented for highly distressed families.
Patients with cystic fibrosis who could not receive the CFTR modulator treatment: What did they lose in 1 year?
Authors: Uytun Salih , Cinel Güzin , Eryılmaz Polat Sanem , Özkan Tabakçı Satı , Kiper Nural , Yalçın Ebru , Ademhan Tural Dilber , Özsezen Beste , Şen Velat , Selimoğlu Şen Hadice , Ufuk Altıntaş Derya , Çokuğraş Haluk , Kılınç Ayşe Ayzıt , Başkan Azer Kılıç , Yazan Hakan , Çollak Abdulhamit , Uzuner Selçuk , Ünal Gökçen , Yılmaz Aslı İmran , Çağlar Hanife Tuğçe , Damadoğlu Ebru , Irmak İlim , Demir Esen , Kartal Öztürk Gökçen , Bingöl Ayşen , Başaran Erdem , Sapan Nihat , Canıtez Yakup , Tana Aslan Ayşe , Asfuroğlu Pelin , Harmancı Koray , Köse Mehmet , Hangül Melih , Özdemir Ali , Çobanoğlu Nazan , Özcan Gizem , Keskin Özlem , Yüksel Hasan , Özdoğan Şebnem , Topal Erdem , Çaltepe Gönül , Can Demet , Korkmaz Ekren Pervin , Kılıç Mehmet , Emiralioğlu Nagehan , Şişmanlar Eyüboğlu Tuğba , Pekcan Sevgi , Çakır Erkan , Özçelik Uğur , Doğru Deniz 
Published: June 2023

AbstractBackgroundCystic fibrosis (CF) is an autosomal recessive disorder caused by CF transmembrane conductance regulator (CFTR) genetic variants. CFTR modulators improve pulmonary function and reduce respiratory infections in CF. This study investigated the clinical and laboratory follow‐up parameters over 1 year in patients with CF who could not receive this treatment.MethodsThis retrospective cohort study included 2018 and 2019 CF patient data from the CF registry of Turkey. Demographic and clinical characteristics of 294 patients were assessed, who had modulator treatment indications in 2018 but could not reach the treatment.ResultsIn 2019, patients younger than 18 years had significantly lower BMI z‐scores than in 2018. During the 1‐year follow‐up, forced expiratory volumes (FEV1) and FEV1 z‐scores a trend toward a decrease. In 2019, chronic Staphylococcus aureus colonization, inhaled antipseudomonal antibiotic use for more than 3 months, oral nutritional supplement requirements, and oxygen support need increased.ConclusionsPatients who had indications for modulator treatments but were unable to obtain them worsened even after a year of follow‐up. This study emphasized the importance of using modulator treatments for patients with CF in our country, as well as in many countries worldwide.
Valosin‐containing protein (VCP/p97) is prognostically unfavorable in pediatric AML, and negatively correlates with unfolded protein response proteins IRE1 and GRP78: A report from the Children's Oncology Group
Authors: Hoff Fieke W. , Qiu Yihua , Brown Brandon D. , Gerbing Robert B. , Leonti Amanda R. , Ries Rhonda E. , Gamis Alan S. , Aplenc Richard , Kolb Edward Anders , Alonzo Todd A. , Meshinchi Soheil , Jenkins Gaye N. , Horton Terzah M. , Kornblau Steven M. 
Published: June 2023

AbstractPurposeThe endoplasmic reticulum (ER) is the major site of protein synthesis and folding in the cell. ER‐associated degradation (ERAD) and unfolded protein response (UPR) are the main mechanisms of ER‐mediated cell stress adaptation. Targeting the cell stress response is a promising therapeutic approach in acute myeloid leukemia (AML).Experimental DesignProtein expression levels of valosin‐containing protein (VCP), a chief element of ERAD, were measured in peripheral blood samples from in 483 pediatric AML patients using reverse phase protein array methodology. Patients participated in the Children's Oncology Group AAML1031 phase 3 clinical trial that randomized patients to standard chemotherapy (cytarabine (Ara‐C), daunorubicin, and etoposide [ADE]) versus ADE plus bortezomib (ADE+BTZ).ResultsLow‐VCP expression was significantly associated with favorable 5‐year overall survival (OS) rate compared to middle‐high‐VCP expression (81% versus 63%, p < 0.001), independent of additional bortezomib treatment. Multivariable Cox regression analysis identified VCP as independent predictor of clinical outcome. UPR proteins IRE1 and GRP78 had significant negative correlation with VCP. Five‐year OS in patients characterized by low‐VCP, moderately high‐IRE1 and high‐GRP78 improved after treatment with ADE+BTZ versus ADE (66% versus 88%, p = 0.026).Conclusion and Clinical RelevanceOur findings suggest the potential of the protein VCP as biomarker in prognostication prediction in pediatric AML.
Termite cuticular extracts improve acceptance of bait for controlling invasive Asian needle ants, Brachyponera chinensis
Authors: Buczkowski Grzegorz 
Published: June 2023

AbstractBACKGROUNDThe Asian needle ant, Brachyponera chinensis, is an invasive ant currently spreading in urban and natural habitats throughout the eastern United States. Recent studies have documented the negative impact of B. chinensis on native ecosystems and human health, yet effective control strategies are lacking. Control difficulties are, in part, due to the unique biology of B. chinensis, which is a predatory ant and a termite specialist. Given that subterranean termites are an important nutritional resource for B. chinensis, the current study evaluated the potential of termite cuticular extract to improve the target‐specificity and efficacy of commercial bait used for B. chinensis control.RESULTSThe efficacy of bait augmented with termite cuticular extracts was evaluated in laboratory and field trials. In laboratory assays, B. chinensis colonies were offered granular bait treated with termite cuticular extract. Results demonstrated that the acceptance of commercial bait is significantly increased by the addition of termite cuticular extract or synthetic (Z)‐9‐pentacosene, a major component of termite cuticular extract. Foraging activity of Asian needle ants was significantly greater on baits augmented with termite cuticular extract or (Z)‐9‐pentacosene relative to standard bait. Furthermore, bait augmented with termite cuticular extract worked substantially faster relative to standard bait. To evaluate population effects, field studies were conducted in forested areas invaded by B. chinensis. Bait treated with termite cuticular extract scattered on the forest floor provided rapid control of B. chinensis and ant densities throughout the treated plots declined by 98% within 14 days.CONCLUSIONThe incorporation of termite cuticular extracts and individual cuticular hydrocarbons such as (Z)‐9‐pentacosene into traditional baits used for B. chinensis control may offer a novel tool to manage this increasingly problematic invasive ant. © 2023 The Author. Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
Therapeutic prospects of naturally occurring p38 MAPK inhibitors tanshinone IIA and pinocembrin for the treatment of SARS‐CoV‐2‐induced CNS complications
Authors: Valipour Mehdi 
Published: June 2023

AbstractP38 mitogen‐activated protein kinase (p38 MAPK) signaling pathway is closely related to severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) replication and hyperinflammatory responses in coronavirus disease 2019 (COVID‐19). Therefore, blood–brain barrier‐penetrating p38 MAPK inhibitors have good potential for the treatment of central nervous system (CNS) complications of COVID‐19. The aim of the present study is the characterization of the therapeutic potential of tanshinone IIA and pinocembrin for the treatment of CNS complications of COVID‐19. Studies published in high‐quality journals indexed in databases Scopus, Web of Science, PubMed, and so forth were used to review the therapeutic capabilities of selected compounds. In continuation of our previous efforts to identify agents with favorable activity/toxicity profiles for the treatment of COVID‐19, tanshinone IIA and pinocembrin were identified with a high ability to penetrate the CNS. Considering the nature of the study, no specific time frame was determined for the selection of studies, but the focus was strongly on studies published after the emergence of COVID‐19. By describing the association of COVID‐19‐induced CNS disorders with p38 MAPK pathway disruption, this study concludes that tanshinone IIA and pinocembrin have great potential for better treatment of these complications. The inclusion of these compounds in the drug regimen of COVID‐19 patients requires confirmation of their effectiveness through the conduction of high‐quality clinical trials.
Mixed Mycobacterium kansasii and Mycobacterium smegmatis infection in an adult‐onset immunodeficiency patient with anti‐interferon‐γ autoantibodies
Authors: Chou Yun‐Tse , Liao Wei‐An , Kuo Chin‐Wei 
Published: June 2023

AbstractAnti‐interferon‐gamma autoantibody (AIGA) is a rare adult‐onset immunodeficiency disease that increases the risk of occult infection. Nontuberculous mycobacteria (NTM) infections represent a diverse group of species and subspecies, and mixed infections with two or more NTM species have been reported. However, there is no consensus on the optimal antibiotics or immune modulator treatments for mixed NTM infections in AIGA patients. Here, we present the case of a 40‐year‐old female who initially presented with suspected lung cancer with obstructive pneumonitis. Tissue samples obtained through bronchoscopy, endoscopy, and bone marrow biopsy revealed disseminated mycobacterium infection. PCR‐based testing confirmed a mixed pulmonary infection with Mycobacterium kansasii and Mycobacterium smegmatis, as well as M. kansasii bacteremia. The patient received 12 months of anti‐NTM medications for M. kansasii, and the symptoms improved. Additionally, the images showed resolution after 6 months, even without the need for immune modulator treatment.
Molten‐Salt Electrochemical Deoxidation Synthesis of Platinum‐Neodymium Nanoalloy Catalysts for Oxygen Reduction Reaction
Authors: Fan Chenming , Li Guomin , Gu Jingjiu , Wang Qiang , Li Shenggang , Li Bing 
Published: June 2023

AbstractPlatinum‐rare earth metal (Pt‐RE) nanoalloys are regarded as a potential high performance oxygen reduction reaction (ORR) catalyst. However, wet chemical synthesis of the nanoalloys is a crucial challenge because of the extremely high oxygen affinity of RE elements and the significantly different standard reduction potentials between Pt and RE. Here, this paper presents a molten‐salt electrochemical synthetic strategy for the compositional‐controlled preparation of platinum‐neodymium (Pt‐Nd) nanoalloy catalysts. Carbon‐supported platinum‐neodymium (PtxNd/C) nanoalloys, with distinct compositions of Pt5Nd and Pt2Nd, are obtained through molten‐salt electrochemical deoxidation of platinum and neodymium oxide (Pt‐Nd2O3) precursors supported on carbon. The PtxNd/C nanoalloys, especially the Pt5Nd/C exhibit a mass activity of 0.40 A mg−1Pt and a specific activity of 1.41 mA cm−2Pt at 0.9 V versus RHE, which are 3.1 and 7.1 times higher, respectively, than that of commercial Pt/C catalyst. More significantly, the Pt5Nd/C catalyst is remarkably stable after undergoing 20 000 accelerated durability cycles. Furthermore, the density‐functional‐theory (DFT) calculations confirm that the ORR catalytic performance of PtxNd/C nanoalloys is enhanced by compressive strain effect of Pt overlayer, causing a suitable weakened binding energies of O* and .