bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clonal expansion of resident memory T cells in peripheral blood of patients with non-small cell lung cancer during immune checkpoint inhibitor treatment
Authors: Kim Hyunsu , Park Sehhoon , Han Kyoung-Yeon , Lee Naeun , Kim Hyemin , Jung Hyun Ae , Sun Jong-Mu , Ahn Jin Seok , Ahn Myung-Ju , Lee Se-Hoon , Park Woong-Yang 
Published: February 2023

BackgroundImmune checkpoint inhibitors (ICIs) are an essential treatment for non-small cell lung cancer (NSCLC). Currently, the tumor-related intrinsic factors in response to ICIs have mostly been elucidated in tissue samples. However, tissue immune status and changes in the immune microenvironment can also be reflected and monitored through peripheral blood.MethodsSingle-cell RNA and T cell receptor (scTCR) sequencing were conducted using peripheral blood mononuclear cells (PBMCs) from 60 patients with stage IV NSCLC. Those samples were prospectively acquired from patients treated with anti-PD(L)-1 therapy for advanced lung cancer. Based on the clinical outcomes, samples were classified as durable clinical benefit (DCB) and non-durable clinical benefit (NCB). The samples constituted paired longitudinal samples, consisting of pre-treatment and on-treatment. Additionally, PBMC samples from 60 healthy donors from the Asian Immune Diversity Atlas project were used as a control.ResultsThe dynamic changes in major cell types between pre-treatment and on-treatment PBMCs were associated with an increase in proliferating T cells and NK cells in both DCB and NCB groups. Among T cell subtypes, effector memory CD8+T cells (CD8+TEM_GZMK_PDCD1) were increased after ICI treatment in both DCB and NCB. From the lineage trajectory analysis, effector memory CD8+T cells resided at the bifurcation point, which has the potential to differentiate into lineages with precursor exhausted CD8+T cells (CD8+TCMcells) assumed to be related to the ICI response. From the scTCR-seq, effector memory CD8+T cells along with T cells recognizing unknown antigen expanded and composed of novel clones skewed toward dysfunctional status, especially in on-treatment samples of the DCB group. The extent of immunophenotype conversion capabilities of the TCR with effector memory CD8+T cells showed remarkable variation in the on-treatment sample in the DCB group.ConclusionA transitioning T cell subtype identified in PBMCs might be related to the prolonged ICI response. From our study, expansion of effector memory CD8+T cells with novel TCRs in PBMCs after ICI treatment could contribute to a better clinical outcome in patients with NSCLC. This proof-of-concept research strengthens the use of non-invasive PBMCs in studying systemic changes of immune reactions related to the ICI treatment.
Risks of mortality and severe coronavirus disease 19 (COVID-19) outcomes in patients with or without systemic lupus erythematosus
Authors: Bruera Sebastian , Lei Xiudong , Zhao Hui , Yazdany Jinoos , Chavez-MacGregor Mariana , Giordano Sharon H , Suarez-Almazor Maria E 
Published: February 2023

ObjectivesWe compared the outcomes of patients with or without systemic lupus erythematosus (SLE) who were diagnosed with coronavirus disease 19 (COVID-19) and evaluated factors within patients with SLE associated with severe outcomes.MethodsThis retrospective cohort study used the deidentified Optum COVID-19 electronic health record dataset to identify patients with COVID-19 from 1/1/2020 to 31/12/2020. Cases with SLE were matched with general controls at a ratio of 1:10 by age, sex, race and ethnicity and COVID-19 diagnosis date. Outcomes included 30-day mortality, mechanical ventilation, hospitalisation and intensive care unit admission. We evaluated the relationship between COVID-19-related outcomes and SLE using multivariable logistic regression. In addition, within SLE cases, we examined factors associated with COVID-19 related outcomes, including disease activity and SLE therapy.ResultsWe included 687 patients matched with 6870 controls. Unadjusted rates of outcomes for patients with SLE were significantly worse than for matched controls including mortality (3.6% vs 1.8%), mechanical ventilation (6% vs 2.5%) and hospitalisation (31% vs 17.7%) (all p<0.001). After multivariable adjustment, patients with SLE had increased risks of mechanical ventilation (OR 1.81, 95% CI 1.16 to 2.82) and hospitalisation (OR 1.32, 95% CI 1.05 to 1.65). Among patients with SLE, severe disease activity was associated with increased risks of mechanical ventilation (OR 5.83, 95% CI 2.60 to 13.07) and hospitalisation (OR 3.97, 95% CI 2.37 to 6.65). Use of glucocorticoids, mycophenolate and tacrolimus before COVID-19 was associated with worse outcomes.ConclusionPatients with SLE had increased risk of severe COVID-19-related outcomes compared with matched controls. Patients with severe SLE disease activity or prior use of corticosteroids experienced worse outcomes.
Logarithmic corrections to O(a) and O($$a^2$$) effects in lattice QCD with Wilson or Ginsparg–Wilson quarks
Authors: Husung Nikolai 
Published: February 2023

AbstractWe derive the asymptotic lattice spacing dependence $$a^n[2b_0\bar{g}^2(1/a)]^{\hat{\Gamma }_i}$$

a
n

[
2

b
0

g

¯

2

(
1
/
a
)

]

Γ
^

i

relevant for spectral quantities of lattice QCD, when using Wilson, $$\textrm{O}(a)$$

O
(
a
)

improved Wilson or Ginsparg–Wilson quarks. We give some examples for the spectra encountered for $$\hat{\Gamma }_i$$

Γ
^

i

including the partially quenched case, mixed actions and using two different discretisations for dynamical quarks. This also includes maximally twisted mass QCD relying on automatic $$\textrm{O}(a)$$

O
(
a
)

improvement. At $$\textrm{O}(a^2)$$

O
(

a
2

)

, all cases considered have $$\min _i\hat{\Gamma }_i\gtrsim -0.3$$

min
i

Γ
^

i

≳
-
0.3

if $$N_{\textrm{f}}\le 4$$

N
f

≤
4

, which ensures that the leading order lattice artifacts are not severely logarithmically enhanced in contrast to the O(3) non-linear sigma model (Balog et al. in Nucl Phys B 824:563–615, 2010; Balog et al. in Phys Lett B 676:188–192, 2009). However, we find a very dense spectrum of these leading powers, which may result in major pile-ups and cancellations. We present in detail the computational strategy employed to obtain the 1-loop anomalous dimensions already used in Husung et al. (Phys Lett B 829:137069, 2022).
Shark evacuation from Mo’orea island in 2002
Authors: Porcher Ila France 
Published: February 2023

Abstract
Reef sharks, including blackfins (Carcharhinus melanopterus) reside in the lagoons and on the outer slopes of the barrier reefs of Mo’orea Island, French Polynesia. In general the lagoons are shallow enough to permit underwater observation, while dive clubs hold shark dives at different sites in the lagoons and in the ocean. Thus, the presence of blackfin sharks especially, and other species at times, is confirmed daily. Between about 21 July and 2 August 2002, all blackfin reef sharks under observation, and possibly some of the other species, left their lagoon and ocean ranges and disappeared from human view, a unique evacuation for which no explanation was found. The event suggests an unknown pattern or influence at work which was perceived by sharks, but was not apparent to those investigating.
Prediction of Intermonth Modes of Winter Air Temperature over China
Authors: Yang Hongqing , Fan Ke , Dai Haixia 
Published: February 2023

Abstract
The features and causes of the leading intermonth modes of winter surface air temperature anomalies (SATA) over China are investigated, and associated prediction models are developed. The first three intermonth modes of winter SATA over China are obtained by extended empirical orthogonal function (i.e., EEOF1–3) analysis. The results show that EEOF1 represents consistent variations in the whole winter, with a variance contribution of 32.3%, whereas EEOF2 and EEOF3 show spatiotemporally inconsistent changes, and their variance contributions are 16.9% and 12.5%, respectively. EEOF2 has out-of-phase variations between December and January–February, and EEOF3 exhibits a temporal warm–cold alternating pattern, with spatially reversing changes over northwestern and southern China. However, the Climate Forecast System, version 2 (CFSv2) presents a limited prediction skill for winter SATA over China and their intermonth modes. Further investigations indicate that the September sea ice over the Barents–Laptev Seas, the November snow cover over western Europe and East Asia, and the November northern Atlantic sea surface temperature can be, respectively, adopted to develop prediction schemes for the consistent mode (EEOF1 scheme) and two inconsistent modes (EEOF2 and EEOF3 schemes) based on specific mechanisms. These schemes show effective performances in predicting both individual modes and the reconstruction field of SATA over China. The temporal correlation coefficients (TCCs) between cross-validation results and observations are 0.48, 0.51, and 0.31 for the EEOF1–3 modes, respectively (the 90% confidence level is 0.27). For the reconstruction field, the TCCs are 0.40, 0.27, and 0.45 in December, January, and February, respectively, which are much higher than those of the CFSv2 outputs (0.23, −0.16, and −0.09).
Apixaban for Extended Thromboprophylaxis After Oncologic Resection: Outcomes and Cost Analysis
Authors: Kelly Kathrine , Blanck Lauren M. , Lim Kelvin , Norman Alexa , Roberto Charlaine V. , Assifi M. Mura , Wright G. Paul , Chung Mathew 
Published: February 2023

Background Patients undergoing oncologic resection are at risk of developing venous thromboembolism (VTE), and this can lead to increased morbidity and hospital costs. Low-molecular weight heparin (LMWH) is recommended as extended thromboprophylaxis (ETP) in high-risk patients and has been shown to reduce rates of VTE. Methods This is a retrospective review of consecutive patients undergoing resection for oncologic indications at a single institution from May 2016 to May 2019. This study evaluated the use of apixaban as ETP at discharge. The primary outcomes were deep vein thrombosis (DVT), pulmonary embolism (PE), or mesenteric/portal venous thromboembolism at 30, 60, and 90 days postoperatively. Results A total of 600 patients were included; 449 patients received no ETP, and 151 patients received apixaban. PE occurred in 1.1, 1.6, and 2.3% of patients without ETP and 0, 0, and .7% of patients in the apixaban group (at 30, 60, and 90 days; P = .338, P = .201, and P = .306, respectively). DVT occurred in 1.8, 2.1, and 2.8% of patients without ETP and 0, 0, and 1.4% in the apixaban group ( P = .211, P = .121, and P = .535, respectively). The total cost, including ETP and readmission for VTE, per patient was US $5.51 more in the apixaban group. Conclusion Apixaban therapy for ETP did not produce a statistically significant reduction in VTE events in our patients. Future studies should include more patients in a prospective multicenter trial.
Preparing low-Density microcellular polystyrene foam by in-Situ fibrillated PTFE and supramolecular nucleator TMC-300 in the presence of sc-CO2
Authors: Li Zhuolun , Wang Xiangdong , Wang Yaqiao , Chen Shihong 
Published: February 2023

A method using in-situ fibrillated polytetrafluoroethylene (PTFE) and octamethylenedicarboxylicdibenzoylhydrazide (TMC-300) supramolecular nucleator was presented to prepare low density polystyrene foams. This study used a torque rheometer in the molten compound preparation of PS/fibrillated-PTFE/TMC-300 composites. Scanning electron microscopy showed in-situ fibrillated polytetrafluoroethylene in Polystyrene melt and a nanofiber network with high aspect ratio. The formation of nanometer-sized fiber networks improved the melt viscoelasticity of matrices which promoted cell nucleation. As the results demonstrated, low-density foams with 11 μm average cell size were obtained using Polystyrene. The self-assembly nucleating agent TMC-300 was then introduced to the composite materials. TMC-300 and polytetrafluoroethylene as a composite cell nucleating agent were used in Polystyrene foams. Meanwhile, their nucleating efficiency was investigated. TMC-300 completed self-assembly in Polystyrene and served as composite nucleating agent in combination with polytetrafluoroethylene. Compared with the sample PS/PTFE-0.5, the average cell size of the sample PS/PTFE-0.5/TMC-2 had a reduction rate of 28.16% from 12.18 μm to 8.75 μm. The cell density increased by an order of magnitude. The composite nucleating agent was successful in controlling Polystyrene foam cell morphology, thus leading to the preparation of low-density Polystyrene microporous foams.
The Differential Relation of Emotional, Physical, and Sexual Abuse Histories to Antidepressant Treatment Remission and Persistence of Anhedonia in Major Depression: A CAN-BIND-1 Report
Authors: Harkness Kate L. , Chakrabarty Trisha , Rizvi Sakina J. , Mazurka Raegan , Quilty Lena , Uher Rudolf , Milev Roumen V. , Frey Benicio N. , Parikh Sagar V. , Foster Jane A. , Rotzinger Susan , Kennedy Sidney H. , Lam Raymond W. 
Published: February 2023

Objective Childhood maltreatment is a potent enviromarker of risk for poor response to antidepressant medication (ADM). However, childhood maltreatment is a heterogeneous construct that includes distinct exposures that have distinct neurobiological and psychological correlates. The purpose of the current study is to examine the differential associations of emotional, physical, and sexual maltreatment to ADM outcome and to examine the unique role of anhedonia in driving poor response in patients with specific maltreatment histories. Methods In a multicentre clinical trial of major depression, 164 individuals were assessed for childhood emotional, physical, and sexual maltreatment with a contextual interview with independent, standardized ratings. All individuals received 8 weeks of escitalopram, with nonresponders subsequently also receiving augmentation with aripiprazole, with outcomes measured with depression rating scales and an anhedonia scale. Results Greater severity of emotional maltreatment perpetrated by the mother was a significant and direct predictor of lower odds of week 16 remission (odds ratio [OR] = 1.68, P = 0.02). In contrast, the relations of paternal-perpetrated emotional maltreatment and physical maltreatment to week 16 remission were indirect, mediated through greater severity of anhedonia at week 8. Conclusions We identify emotional maltreatment as a specific early exposure that places patients at the greatest risk for nonremission following pharmacological treatment. Further, we suggest that anhedonia is a key symptom domain driving nonremission in patients with particular maltreatment histories.
Silencing lncRNA HCG18 regulates GPX4-inhibited ferroptosis by adsorbing miR-450b-5p to avert sorafenib resistance in hepatocellular carcinoma
Authors: Li Xiaoming , Li Yunhui , Lian Peilong , lv Qigang , Liu Fangfeng 
Published: February 2023

Ferroptosis is potential to relieve drug resistance in hepatocellular carcinoma (HCC). Glutathione peroxidase 4 (GPX4) is a critical modulator of ferroptosis. This study discussed the mechanism of GPX4-inhibited ferroptosis in sorafenib resistance in HCC. HCG18 in HCC cells was detected. Sorafenib resistant (SR) cell line Huh7-SR cells were treated with sorafenib (0, 2.5, 5, 7.5, 10 μM). After silencing HCG18 in Huh7-SR cells, cell activity, proliferation and apoptosis were detected. The levels of iron, the concentration of MDA, GSH and lipid reactive oxygen species (ROS) were measured to evaluate the ferroptosis. The downstream mechanism of HCG18 was predicted and verified. Huh7-SR cells were infected with lentivirus sh-HCG18 to establish xenograft tumor model. HCG18 was elevated in HCC cells and associated with sorafenib resistance. Silencing HCG18 inhibited cell proliferation, promoted apoptosis, and impaired sorafenib resistance. Ferroptosis was inhibited in Huh7-SR cells, while silencing HCG18 inhibited sorafenib resistance by promoting ferroptosis. GPX4 overexpression averted the promotion of sh-HCG18 on ferroptosis, thereby reducing sorafenib resistance. HCG18 sponged miR-450b-5p to regulate GPX4. Collectively, Silencing HCG18 inhibits GPX4 by binding to miR-450b-5p, promotes GPX4-inhibited ferroptosis, and averts sorafenib resistance in HCC.
Widespread vitiligo and poliosis following ipilimumab–nivolumab combination therapy
Authors: Nemovi Khashayar , Jamali Arsia , Matinpour Keyan , Dasanu Constantin A 
Published: February 2023

Introduction Combined immune checkpoint inhibitor therapy has been successfully used in the treatment of several malignancies. Adverse effects with the combination therapy may be more severe than the ones seen with single immune checkpoint inhibitors. Case presentation We report a unique case of a 59-year-old man of dark skin complexion who underwent treatment with intravenous ipilimumab–nivolumab every 3 weeks for metastatic malignant melanoma. After three cycles of this therapy, he developed extensive skin depigmentation that within 6 weeks, affected nearly the entire skin surface, along with progressive poliosis. Management and outcome Ipilimumab–nivolumab therapy was subsequently discontinued due to grade 3 enterocolitis requiring high-dose steroids and intravenous infliximab. About six months later, imaging studies showed a relapse of malignant melanoma. At that juncture, vitiligo affected the total body surface area, resembling albinism, along with near-total poliosis and significant photosensitivity. Pembrolizumab was tried but had to be stopped after three cycles due to the reoccurrence of grade 3 enterocolitis. Progression of malignant melanoma with new brain, lung, liver, subcutaneous, and colonic metastases led to the patient's demise. Conclusion We report a unique case of severe vitiligo and poliosis that involved total body surface area in a Caucasian man with dark complexion, resembling albinism. Further studies are warranted to evaluate the severity of dermatologic side effects with combination immune checkpoint inhibitor therapy.
The Biological Processes of Ferroptosis Involved in Pathogenesis of COVID-19 and Core Ferroptoic Genes Related With the Occurrence and Severity of This Disease
Authors: Zhang Zhengzhong , Pang Tingting , Qi Min , Sun Gengyun 
Published: February 2023

Background: A worldwide outbreak of coronavirus disease 2019 (COVID-19) has resulted in millions of deaths. Ferroptosis is a form of iron-dependent cell death which is characterized by accumulation of lipid peroxides on cellular membranes, and is related with many physiological and pathophysiological processes of diseases such as cancer, inflammation and infection. However, the role of ferroptosis in COVID-19 has few been studied. Material and Method: Based on the RNA-seq data of 100 COVID-19 cases and 26 Non-COVID-19 cases from GSE157103, we identified ferroptosis related differentially expressed genes (FRDEGs, adj. P-value < .05) using the “Deseq2” R package. By using the “clusterProfiler” R package, we performed Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment. Next, a protein-protein interaction (PPI) network of FRDEGs was constructed and top 30 hub genes were selected by cytoHubba in Cytoscape. Subsequently, we established a prediction model for COVID-19 by utilizing univariate logistic regression and the least absolute shrinkage and selection operator (LASSO) regression. Based on core FRDEGs, COVID-19 patients were identified as two clusters using the “ConsenesusClusterPlus” R package. Finally, the miRNA-mRNA network was built by Targetscan online database and visualized by Cytoscape software. Results: A total of 119 FRDEGs were identified and the GO and KEGG enrichment analyses showed the most important biologic processes are oxidative stress response, MAPK and PI3K-AKT signaling pathway. The top 30 hub genes were selected, and finally, 7 core FRDEGs (JUN, MAPK8, VEGFA, CAV1, XBP1, HMOX1, and HSPB1) were found to be associated with the occurrence of COVID-19. Next, the two patterns of COVID-19 patients had constructed and the cluster A patients were likely to be more severe. Conclusion: Our study suggested that ferroptosis was involved in the pathogenesis of COVID-19 disease and the functions of core FRDEGs may become a new research aspect of this disease.
Cognition in patients with neuromyelitis optica spectrum disorders: A prospective multicentre study of 217 patients (CogniNMO-Study)
Authors: Hümmert Martin W , Stern Carlotta , Paul Friedemann , Duchow Ankelien , Bellmann-Strobl Judith , Ayzenberg Ilya , Schwake Carolin , Kleiter Ingo , Hellwig Kerstin , Jarius Sven , Wildemann Brigitte , Senel Makbule , Berthele Achim , Giglhuber Katrin , Luessi Felix , Grothe Matthias , Klotz Luisa , Schülke Rasmus , Gingele Stefan , Faiss Jürgen H , Walter Annette , Warnke Clemens , Then Bergh Florian , Aktas Orhan , Ringelstein Marius , Stellmann Jan-Patrick , Häußler Vivien , Havla Joachim , Pellkofer Hannah , Kümpfel Tania , Kopp Bruno , Trebst Corinna 
Published: February 2023

Background: There is limited and inconsistent information on the prevalence of cognitive impairment in neuromyelitis optica spectrum disorders (NMOSD). Objective: To assess cognitive performance and changes over time in NMOSD. Methods: This study included data from 217 aquaporin-4-IgG-seropositive (80%) and double-seronegative NMOSD patients. Cognitive functions measured by Symbol Digit Modalities Test (SDMT), Paced Auditory Serial-Addition Task (PASAT), and/or Multiple Sclerosis Inventory Cognition (MuSIC) were standardized against normative data ( N = 157). Intraindividual cognitive performance at 1- and 2-year follow-up was analyzed. Cognitive test scores were correlated with demographic and clinical variables and assessed with a multiple linear regression model. Results: NMOSD patients were impaired in SDMT ( p = 0.007), MuSIC semantic fluency ( p < 0.001), and MuSIC congruent speed ( p < 0.001). No significant cognitive deterioration was found at follow-up. SDMT scores were related to motor and visual disability ( pBon < 0.05). No differences were found between aquaporin-4-IgG-seropositive and double-seronegative NMOSD. Conclusions: A subset of NMOSD patients shows impairment in visual processing speed and in semantic fluency regardless of serostatus, without noticeable changes during a 2-year observation period. Neuropsychological measurements should be adapted to physical and visual disabilities.
Parental income gradients in child and adolescent mortality: Norwegian trends over half a century
Authors: Evensen Miriam , Klitkou Søren Toksvig , Tollånes Mette Christophersen , Júlíusson Pétur Benedikt , Kravdal Øystein 
Published: February 2023

Background: Child mortality has declined rapidly over the last century in many high-income countries. However, little is known about the socio-economic differences in this decline and whether these vary across causes of death. Methods: We used register data that included all Norwegian births between 1968 and 2010 (2.1 million), and we analysed how all-cause and cause-specific child (0–4 years) and adolescent (5–20 years) mortality rates vary with relative parental income the year before the birth. Results: Child and adolescent all-cause mortality decreased with increasing parental relative income within all birth cohorts. Among children aged 0–4 years, the socio-economic gradient in all-cause mortality and in mortality due to external causes, sudden infant deaths and perinatal factors declined over the period, while there was no systematic decline in mortality from congenital malformations. Among children aged 5–20 years, the gradient did not weaken similarly, although there were indications of declines in the socio-economic gradient related to all-cause deaths and deaths because of suicides and other external causes. While the absolute differences in mortality declined over time, the relative differences remained stable. Conclusions: Although children of low-income parents still have elevated mortality, there has been a large reduction in child mortality in all socio-economic groups across 50 years for all causes combined and most of the groups of specific causes of death.