bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phytochemical profiling, antioxidant activities, enzymatic activities and insecticidal potential of aqueous extracts of four plants on the larvae of Helicoverpa armigera (Lepidoptera: Noctuidae), the main pest of cotton plant in Ivory Coast
Authors: Bini Kouadio Kra Norbert , Kobenan Koffi Christophe , Kouakou Malanno , Kouadio Ibrahime Sinan , Zengin Gokhan , Jekő József , Cziáky Zoltán , Danho Mathias , Ochou Ochou Germain 
Published: April 2023

AbstractIn the context of climate change, the Ivorian cotton industry is facing with the loss of sensitivity of pests (Helicoverpa armigera) and the appearance of new so‐called emerging insects. Faced with this situation, cotton producers tend to use insecticide products in high doses, in excess of the norm. However, the misuse of chemical products poses many health risks. Therefore, to limit the use of chemicals, aqueous extracts of local plants with insecticidal properties were examined in the laboratory and in the field. Four local plant species were selected [Anacardium occidentale (Anarcardier); Azadirachta indica (Neem); Hyptis suaveolens (Hyptis) and Tephrosia vogelii (Tephrosia)]. After determining the chemical profiles of the four extracts by high performance liquid chromatography (HPLC)‐mass spectrometry, their inhibitory activities were assessed in cholinesterase and tyrosinase. The sensitivity of Helicoverpa armigera larvae was evaluated by ingesting the aqueous extracts at several concentrations ranging from 2% to 64% in an artificial nutrient substrate. Then, the mortality rates of the larvae during 72 h were evaluated and the lethal concentrations were determined. The results of chemical analyses (HPLC) showed that the richest aqueous extract in phytochemicals with 54 elements detected was that of cashew (A. occidentale). T. vogelii, A. indica and H. suaveolens presented 44, 45, and 39 chemical compounds, respectively. In addition, the total phenolic content was higher in A. occidentale (110.67 mg gallic acid equivalents/g) followed by A. indica (42.43 mg gallic acid equivalents/g). The highest antioxidant ability was observed with the aqueous extract of cashew (A. occidentale). Anti‐enzymatic activities such as acetylcholinesterase, butyrylcholinesterase and tyrosinase inhibition were most pronounced in A. occidentale (2.35 ± 0.02 mg galanthamine equivalent/g, 3.77 ± 0.01 mg galanthamine equivalent/g and 71.28 ± 0.07 mg kojic acid equivalent/g, respectively). The most toxic aqueous extract for H. armigera larvae was that of cashew with a lethal concentration LC50 = 11.68%. Moreover, the principal component analysis performed showed that the insecticidal activity is strongly correlated with the antioxidant and enzymatic activities of the aqueous extracts. Then, the hierarchical ascending classification showed cashew as the best plant. For the sustainability of cotton production, it would be necessary to limit the use of chemical‐synthetic insecticides through the use of plant extracts, especially from cashew leaves.
Efficacy and Safety of Lenabasum, a Cannabinoid Type 2 Receptor Agonist, in a Phase 3 Randomized Trial in Diffuse Cutaneous Systemic Sclerosis
Authors: Spiera Robert , Kuwana Masataka , Khanna Dinesh , Hummers Laura , Frech Tracy M. , Stevens Wendy , Matucci‐Cerinic Marco , Kafaja Suzanne , Distler Oliver , Jun Jae‐Bum , Levy Yair , Leszcyzński Piotr , Gordon Jessica , Steen Virginia , Lee Eun Bong , Jankowski Tomasz , Litinsky Irena , Chung Lorina , Hsu Vivien , Mayes Maureen , Sandorfi Nora , Simms Robert W. , Finzel Stephanie , de Vries‐Bouwstra Jeska , Constantine Scott , Dgetluck Nancy , Dinh Quinn , Bloom Bradley J. , Furst Daniel E. , White Barbara , Denton Christopher P. ,   the RESOLVE‐1 Study Group
Published: April 2023

ObjectiveThis phase 3 study was undertaken to investigate the efficacy and safety of lenabasum, a cannabinoid type 2 receptor agonist, in patients with diffuse cutaneous systemic sclerosis (dcSSc).MethodsA multinational double‐blind study was conducted in 365 dcSSc patients who were randomized and dosed 1:1:1 with lenabasum 20 mg, lenabasum 5 mg, or placebo, each twice daily and added to background treatments, including immunosuppressive therapies (IST).ResultsThe primary end point, the American College of Rheumatology combined response index in dcSSc (CRISS) at week 52 for lenabasum 20 mg twice a day versus placebo, was not met, with CRISS score of 0.888 versus 0.887 (P = 0.4972, using mixed models repeated measures [MMRM]). The change in the modified Rodnan skin thickness score (MRSS) at week 52 for lenabasum 20 mg twice a day versus placebo was −6.7 versus −8.1 (P = 0.1183, using MMRM). Prespecified analyses showed higher CRISS scores, greater improvement in MRSS, and lower decline in forced vital capacity in patients on background mycophenolate and those who were taking IST for ≤1 year. No deaths or excess in serious or severe adverse events related to lenabasum were observed.ConclusionA benefit of lenabasum in dcSSc was not demonstrated. Most patients were treated with background IST, and treatment with mycophenolate mofetil in particular was associated with better outcomes. These findings support the use of IST in the treatment of dcSSc and highlight the challenge of demonstrating a treatment effect when investigational treatment is added to standard of care IST. These findings have relevance to trial design in SSc, as well as to clinical care.
Fault detection and prediction scheme for nonlinear stochastic distribution systems
Authors: Zhang Chang , Yao Lina , Sun Yuancheng , Qin Jifeng 
Published: April 2023

AbstractModel‐based fault detection technique has a broad range of applications because of the small change to the system when the system state is known to be available and the low cost. For nonlinear stochastic distribution systems containing uncertain disturbance term, a model‐based fault detection and failure time prediction scheme is proposed in this paper, and observers are designed to detect whether the incipient fault has occurred in the system. The residual is obtained by comparing the output of the actual system with the output of the observer. When the residual exceeds the threshold value obtained by derivation, it is determined that the fault has occurred in the system. The fault size can then be estimated in real time and used to determine the time to failure (TTF) or the remaining useful life of the system. The TTF of the system is obtained by comparing the magnitude of the current system fault with the fault threshold. Finally, the feasibility of the presented fault detection scheme is proved by the Lyapunov stability theory and the validity of the scheme is proved by computer simulation.
Evaluation of sequential dosing of potassium permanganate for microcystin‐LR removal
Authors: Hurd Maycee , MacKay Allison A. , Laszakovits Juliana R. 
Published: April 2023

AbstractPermanganate can be scavenged by dissolved organic matter (DOM), which decreases microcystin (MC) removal efficiency, and permanganate attack on cyanobacterial cells can damage cells, resulting in the release of additional MCs. Here, the impact of sequential permanganate doses on MC‐LR removal in the presence of two DOM isolates (terrestrial‐ and algal‐derived) was examined. Although sequential permanganate dosing reduced the competition for permanganate from each DOM isolate, the overall MC removal efficiency was not as high when multiple smaller doses of permanganate were applied compared to one single dose. Potassium permanganate was not observed to lyse Microcystis cells up to 10 mg L−1. Sequential permanganate dosing did not alter the extent of lysis observed for a model bacterium. Mathematical simulations of permanganate oxidation in the presence of DOM suggested that sequential dosing would be most beneficial for enhancing MC‐LR removal when a small portion of highly reactive DOM exists.
Synthesis of nanostructured silica particles for controlled release of ascorbic acid: Microstructure features and in vitro scratch wound assay
Authors: Alhadhrami Nahlah A. , Alatawi Raedah A. S. 
Published: April 2023

AbstractTo date, the long term stability of ascorbic acid (AA) under physiological conditions represents a major issue for wound healing and tissue regeneration applications. In this study, ascorbyl phosphate (AP) was loaded into silica nanoparticles (SiNPs) through a simple one step procedure, in which spherical shaped porous SiNPs were obtained via hydrolysis/condensation of tetraethylorthosilicate (TEOS) in the presence of bicarbonate salt and ammonia. The as‐prepared SiNPs were characterized by scanning electron microscope (SEM), transmission electron microscope (TEM), and Fourier Transformer Infrared Spectrophotometer (FTIR). Incorporation of bicarbonate salt resulted in the formation of spherical SiNPs with an average diameter of 460 ± 89 nm, while further increase of bicarbonate salt led to the formation of silica sheet‐like structures. The AP‐loaded SiNPs exhibited high loading efficiency from 92.3‐ 81.5%, according to AP content and sustained release over 3 days. According to cell viability assay, the obtained AP‐enriched SiNPS showed no toxicity and supportive effect to the proliferation of human skin fibroblast cells (HSF) at a concentration less than 200 µg mL−1. Moreover, it was observed that the wound closure percentage (%) after 24 h was also shown to increase to 74.1 ± 3.1% for 20AP‐loaded SiNPs compared to control samples (50.1 ± 1.8%). The obtained results clearly demonstrated that the developed SiNPs formulation exhibits optimal microstructure features to maintain a sustained release of ascorbic acid AA at wound bed for the healing of skin tissue, including acute and chronic wounds.
Chemical profiling and quantitative analysis on the aqueous extract of Pimpinella anisum fruit by liquid chromatography‐tandem mass spectrometry
Authors: Yang Jing , Cheng Shuohan , Yao Lan , Talifu Ainiwaer , Saimaiti Refuhati , Matnur Yusup , Zhang Chen , Chen Yanhua , Zhou Wenbin , Abliz Zeper 
Published: April 2023

AbstractAnise fruit (Aniseed) has been used for many years as a traditional medicine in various countries throughout the world; however, the chemical material basis of Aniseed water extract (AWE) has not been examined in detail, limiting our understanding of its pharmacological mechanism and methods for practical quality control. A high‐efficiency and high‐sensitivity LC‐triple time‐of‐flight tandem mass spectrometry (MS/MS) analysis method using data processing method combined with product ion and neutral loss filtering for systematic screening and identification of the constituents of AWE was established. A quantitative method was established by using LC–MS/MS with multiple reaction monitoring for 10 min to determine the concentration of 17 representative constituents. A total of 89 compounds were discovered in AWE, of which 31 were confirmed by the reference standards, while 24 were found in Aniseed for the first time. The qualification analysis results showed that chlorogenic acids and luteolin derivatives were the major compounds. The linearity, sensitivity, precision, stability, repeatability, and accuracy of the method were verified, which demonstrated that the method could meet the requirements for quantification. This work contributes to a better understanding of the chemical material basis of Aniseed and assists in the development of effective analytical methods for natural medicines.
NUMERICAL ANALYSIS OF EARLY AGE MOVEMENT IN GROUTED CONNECTIONS
Authors: Henneberg J. , Schaumann P. 
Published: April 2023

AbstractGrouted connections (GC) of offshore structures are susceptible to wave loading and current directly after grouting. Early age movement (EAM) during the curing process can affect the material properties and the interface quality between the grout and the steel structure. Such effects were observed in laboratory tests performed at the Leibniz University Hannover. Generally, EAM can be characterised by high shear rates and identified as a damage mechanism. In this contribution, the authors present a numerical approach that transfers the observed damage mechanism into an ultimate strength analyses of the GCs. For this purpose, EAM simulations and laboratory tests with fluid grout material are combined to determine areas of high shear rates, which mainly affect the grout properties. With an element‐based adjustment approach, the material law of each element is adjusted according to the level of shear rate. The adjusted finite element model is analysed on its maximum axial load resistance.
Clusterization‐Triggered Room Temperature Phosphorescence Supramolecular Assembly with Extraordinary Stimulus‐responsive Features from Nonaromatic Amino Acids
Authors: Zhang Peng , Zhang Shenjie , Yang Jing , Li Peng , Li Huanrong 
Published: April 2023

AbstractAchieving stimulus‐responsive performance in room‐temperature phosphorescence (RTP) materials especially systems without classic conjugated groups is attractive and important but remains a great challenge. Herein we propose a universal approach to construct colors‐tunable RTP supramolecular co‐assemblies (AC@amino acid) with excitation wavelength‐dependent properties through co‐assembly of functional aminoclay (AC) and nonconjugated amino acid using environmentally friendly strategy. Experimental and theoretical results successfully disclose that the RTP feature is attributable to space conjugation through effective space electronic communications among different π and n (lone pair) electrons of amino acid molecules and the effective stabilization of their triplet state by AC. Meanwhile, their colors‐tunable performances are mainly owing to the co‐existence of clusters with different aggregates degree through recrystallization of amino acid taking AC as a template. Importantly, AC@amino acid exhibit sensitive stimulus response features towards water, yet their RTP performance can be maintained in other solvents, such as ethanol (EtOH). By virtue of this unique feature, multilevel information encryption application were demonstrated. This work provides a unique insight and more deep understanding on designing novel RTP systems without classic conjugated groups. Importantly, their extraordinary stimulus‐responsive performances endow these RTP systems with a highly promising potential for intelligent information encryption applications.
Simultaneous co‐overexpression of Saccharomyces cerevisiae septins Cdc3 and Cdc10 drives pervasive, phospholipid‐, and tag‐dependent plasma membrane localization
Authors: Benson Aleyna , McMurray Michael 
Published: April 2023

AbstractSeptin proteins contribute to many eukaryotic processes involving cellular membranes. In the budding yeast Saccharomyces cerevisiae, septin hetero‐oligomers interact with the plasma membrane (PM) almost exclusively at the future site of cytokinesis. While multiple mechanisms of membrane recruitment have been identified, including direct interactions with specific phospholipids and curvature‐sensitive interactions via amphipathic helices, these do not fully explain why yeast septins do not localize all over the inner leaflet of the PM. While engineering an inducible split‐yellow fluorescent protein (YFP) system to measure the kinetics of yeast septin complex assembly, we found that ectopic co‐overexpression of two tagged septins, Cdc3 and Cdc10, resulted in nearly uniform PM localization, as well as perturbation of endogenous septin function. Septin localization and function in gametogenesis were also perturbed. PM localization required the C‐terminal YFP fragment fused to the C terminus of Cdc3, the septin‐associated kinases Cla4 and Gin4, and phosphotidylinositol‐4,5‐bis‐phosphate (PI[4,5]P2), but not the putative PI(4,5)P2‐binding residues in Cdc3. Endogenous Cdc10 was recruited to the PM, likely contributing to the functional interference. PM‐localized septins did not exchange with the cytosolic pool, indicative of stable polymers. These findings provide new clues as to what normally restricts septin localization to specific membranes.
A hybrid multicategory framework for generating automated trading systems
Authors: Kumar Deepak , Sahoo Kartik , Thakur Manoj 
Published: April 2023

AbstractThis work proposes a framework for producing automatic trading systems that suggest making trading decisions in financial markets. The trading systems thus generated utilize multicategory classifiers. A collection of important technical indicators are considered as input features for the underlying multicategory classifiers. The proposed trading systems also have an option to use random forest (RF) algorithms for feature selection. The trading range breakout strategy is used to train the proposed trading systems thus generating “BUY/SELL/WAIT” trading signals on daily open prices. The performances of the proposed trading systems are evaluated over five future indices. Empirical findings suggest that the day trading systems based on the proposed multicategory SVM classifiers along with the RF technique outperform the day trading systems built using the multicategory classifiers taken from the literature. The trading range breakout strategy‐based systems are found to be superior to the traditional BUY‐HOLD strategy and that of RF‐PSVM (BUY/SELL) based strategy.
Acylglycine Analysis by Ultra‐Performance Liquid Chromatography‐Tandem Mass Spectrometry (UPLC‐MS/MS)
Authors: Hobert Judith A. , Guymon Rebecca , Yuzyuk Tatiana , Pasquali Marzia 
Published: April 2023

AbstractQuantitative analysis of urine acylglycines has shown to be a highly sensitive and specific method with proven clinical utility for the diagnosis of several inherited metabolic disorders including: medium chain acyl‐CoA dehydrogenase deficiency, multiple acyl‐CoA dehydrogenase deficiency, short chain acyl‐CoA dehydrogenase deficiency, 3‐methylcrotonyl‐CoA carboxylase deficiency, 2‐methylbutyryl‐CoA dehydrogenase deficiency, isovaleric acidemia, propionic academia, and isobutyryl‐CoA dehydrogenase deficiency. Here, a method that is currently performed using ultra‐performance liquid chromatography/tandem mass spectrometry (UPLC‐MS/MS) is described. © 2023 Wiley Periodicals LLC.Basic Protocol: Urinary acylglycine analysis by UPLC‐MS/MSSupport Protocol 1: Quality control preparationSupport Protocol 2: Internal standard (ISTD) preparationSupport Protocol 3: Standard (STD)/calibrator preparation
Sliding mode pulse‐width modulation of five‐leg converter for grid‐connected permanent magnet synchronous generator wind turbine
Authors: Bounadja Mohamed , Belmadani Bachir 
Published: April 2023

SummaryThis paper presents sliding mode pulse‐width modulation (SMPWM) for current‐controlled five‐leg converter (FLC) in wind energy system. The proposed topology substitutes at once two three‐phase converters, classified as back‐to‐back (BTB), by sharing one leg between the permanent magnet synchronous generator (PMSG) and power grid. To overcome the coupling of the two sides, the control of common leg is introduced. SMPWM methodology is designed using system dynamic model and surface decoupling approach to make system tracking desired references. The reference currents are selected to perform control requirements of PMSG wind turbine. The phase currents are controlled simultaneously during normal operation and in the event of unbalanced grid voltages. Different operating conditions are tested under wind variations including a turbulence component. The main objectives are to achieve balanced and sinusoidal currents, as well as smooth active and reactive powers injected into the grid. Simulation results show that FLC can act as BTB converters and demonstrate the effectiveness of the proposed control scheme.
Recent development of urinary biomarkers for bladder cancer diagnosis and monitoring
Authors: Zeng Yuchen , Wang Anqi , Lv Wei , Wang Qingqing , Jiang Shiqi , Pan Xiaoguang , Wang Fei , Yang Huanming , Bolund Lars , Lin Chunhua , Han Peng , Luo Yonglun 
Published: April 2023

AbstractUrine‐based liquid biopsy has emerged as a non‐invasive and effective tool for early screening and diagnosis of bladder cancer. This review provides a comprehensive overview of the current urine‐based biomarkers and methods for the detection and monitoring of bladder cancer. We focus on biomarkers including tumour DNAs, proteins, microbiome, tumour RNAs, long non‐coding RNAs, transfer RNA‐derived fragments, messenger RNAs, microRNAs, circular RNAs, exosomes and extrachromosomal circular DNA.
Marmots do not drink coffee: Human urine contributions to the nitrogen budget of a popular national park destination
Authors: Baron Jill S. , Weinmann Tim , Acharya Varun Kirk , Charlton Caitlin , Nydick Koren R. , Esser Scott 
Published: April 2023

AbstractReactive nitrogen (Nr) concentrations are higher than expected for mountain lakes in Rocky Mountain National Park, and for many years, high Nr concentrations have been attributed to atmospheric Nr deposition from regional and more distant emission sources, including combustion of fossil fuels and agricultural activities. Here, we estimated the contribution from a very local source, that of human urine, related to intensive use by visitors in Loch Vale Watershed (LVWS). Not only does urine convey hormones, pharmaceuticals, antibiotic‐resistant bacteria, and antibiotic‐resistant genes to the environment, but it also contributes Nr, which contributes to loss of biodiversity and eutrophication. Using caffeine as a specific marker for human urine, we compared the calculated maximum potential input of urine with that from wet atmospheric Nr deposition. The maximum potential input is a worst‐case scenario. Nearly 30,000 and 45,000 people hiked the 4.0 km to the Loch, the lowest lake in LVWS, in June–September 2019 and 2020, respectively. Informal trails and informal latrine sites were mapped, and the contribution of human urine was calculated based on several assumptions, including that each visitor voided their bladder on the ground once per visit somewhere in Loch Vale. The resulting Nr input from urine in Loch Vale for the summer months of June through September was 0.02 kg Nr ha−1, and prorated to a full year, the 2019 potential contribution of human waste was 0.06 kg ha−1 year−1. These values are compared with June–September 1.2 kg Nr ha−1 from wet atmospheric deposition or annual measured 2019 deposition of 2.5 kg Nr ha−1 year−1, to indicate a contribution of 2% Nr to the waters of Loch Vale from local human urine. Most Nr in this alpine and subalpine watershed is still attributable to emissions and subsequent wet atmospheric deposition, but a 2% contribution from human waste is not insignificant. In the very broadest sense, our results document an ecological disturbance from an unprecedented level of human activity in a protected and designated wilderness area. Local solutions to this local problem could include greater outreach to visitors of public lands about the consequences of their activities and installation of latrines.