bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improving ergonomics for the bedside assistant in robotic colorectal surgery
Authors: Wong Shing Wai , Ang Zhen Hao , Crowe Philip 
Published: January 2023

Abstract
The aim of the study was to document when significant bedside assistant (BA) and robotic arm collisions occurred during robotic colorectal surgery (RCS). An observational study of 10 consecutive RCS cases, from May 2022 to September 2022, was performed. Situations when there was significant collision between BA arm and robotic arm (to cause inadvertent movement of the assistant instrument) were documented. The assistant port was randomly placed to the right or the left side of the camera port. Situations which led to detrimental BA ergonomics include dissection at the most peripheral working field, proximity of the target (mesenteric vessels), small bowel retraction, placement of the assistant port in the medial position (on the left side of the camera port), during intra-corporeal suturing and robotic stapler use. The robotic console surgeon can predictably identify and avoid situations when injury to the BA may occur.
Exploring Factors That Contribute to Nursing Students’ Willingness to Report Peer Academic Integrity Violations
Authors: Stevenson Shannon Morris , Flannigan Kathryn , Willey Amanda , Kaur Tresa 
Published: January 2023

Abstract

AIM
The aim of the study was to examine and describe student perceptions of severity of violations, faculty support, and support for program improvement strategies related to willingness to report peer violations.

BACKGROUND
Peer reporting is important when students witness dishonest behaviors. To foster academic integrity, exploration of the willingness to report is needed.

METHOD
Using McCabe’s Academic Integrity Survey-Modified for Nursing Students, 442 baccalaureate students were surveyed.

RESULTS
The more students felt faculty supported related policies, the more willing students were to report (rs
= .298, α = .05). The more students understood what was considered a violation, the more willing they were to report (rs
= .485, α = .05). The more students believed program-wide strategies could prevent violations, the more willing they were to report (rs
= .231, α = .05).

CONCLUSION
Education that helps define academic integrity can contribute to nursing students’ willingness to report peer violations. Faculty support of policies and program-wide strategies contribute.
Pilot Implementation of a Health Equity Checklist to Improve the Identification of Equity-Related Adverse Events
Authors: Fan Linda L. , Sheth Sangini S. , Pettker Christian M. 
Published: January 2023

(Abstracted from Obstet Gynecol 2022;140:667–673)
In assessing the occurrence of an unexpected medical adverse event following pharmaceutical, medical, or surgical treatment, the causal or contributory roles played by bias, systemic racism, and social determinants of health should be investigated. Up to 80% of clinical outcomes are estimated to be driven by social determinants including the environments in which patients live, work, learn, worship, and play.
Clinical Consensus Statement: Vaginal Energy-Based Devices
Authors: Alshiek Jonia , Garcia Bobby , Minassian Vatche , Iglesia Cheryl B. , Clark Amanda , Sokol Eric R. , Murphy Miles , Malik Shazia A. , Kimble Alexis , Shobeiri S. Abbas 
Published: January 2023

(Abstracted from Urogynecology 2022;28:633–648)
The US Food and Drug Administration (FDA) announced a July 2018 public warning for using energy-based devices (EBDs) for performing vaginal cosmetic procedures or vaginal rejuvenation, based on both the imprecision of the term “vaginal rejuvenation” and the lack of FDA approval of the use of any devices such as lasers for any specific gynecologic indication. Some health care providers subspecializing in female reconstructive surgery and pelvic medicine deliver patient services via the EBDs discussed in the FDA Safety Communication.
Compound heterozygosity for novel von Willebrand factor genetic variants associated with von Willebrand disease in two Chinese patients
Authors: Wang Yaqin , Wang Xiong , Lu Yanjun , Zhang Ai , Yu Wen , Hu Qun , Liu Aiguo , Huang Jin-feng 
Published: January 2023

Background
Von Willebrand factor (VWF) encodes a secreted glycoprotein involved in primary hemostasis. Genetic mutations in this gene leading to either quantitation or qualitative defects of VWF, result in von Willebrand disease (VWD), an inherited bleeding disorder.

Methods
In this study, two families with VWD were recruited and submitted to a series of clinical and genetic examinations. prothrombin time, activated partial thromboplastin time, thrombin time, factor VIII coagulant activity (FVIII:C), VWF antigen (VWF:Ag), VWF ristocetin cofactor (VWF:RCo) tests were measured in peripheral blood. F8, F9, and VWF genes were sequenced using next-generation sequencing, and Sanger sequencing was used as a validation method.

Results
Both families had a child suffered spontaneous bleeding. Patient 1 showed normal VWF:Ag, severely decreased FVIII:C and VWF:RCo. Patient 2 showed severely decreased FVIII:C, VWF:Ag, and VWF:RCo. Compound heterozygous mutations of VWF gene were identified in both patients. Patient 1 had a novel deletion variant c.1910_1932del (p.Gly637AlafsTer5) and a missense variant c.605G>A (p.Arg202Gln). Patient 2 had a novel missense variant c.4817T>A (p.Met1606Lys) and a novel missense variant c.5983C>T (p.Pro1995Ser).

Conclusions
We described clinical and molecular features of VWD caused by compound heterozygous mutations in two Chinese patients. Our results expand the variation spectrum of the VWF gene and deepen the understanding of the relationship between the genotype and clinical characteristics of VWD.
The Use of Tenofovir Disoproxil Fumarate and Tenofovir Alafenamide for Preventing Vertical Transmission of Hepatitis B
Authors: Zhu Lin , Park Jaimie , Deng You , Pan Calvin Q. 
Published: January 2023

Background:
Mother-to-child transmission (MTCT) of hepatitis B virus may occur in highly viremic mothers despite the infants receiving appropriate immunoprophylaxis. We aimed to review tenofovir disoproxil fumarate (TDF) and tenofovir alafenamide (TAF) data for preventing MTCT.

Methods and Data Selection:
We performed a systematic review between January 1, 2015 and December 31, 2021 on PUBMED, EMBASE, Cochrane, CNKI, and Wanfang databases. Data was extracted from randomized controlled trials or cohort studies in English or Chinese. The outcomes of interest included the efficacy and safety of TDF versus TAF or TDF/TAF versus placebo for preventing MTCT (PROSPERO registration: CRD42021256656).

Results:
Data from forty-three studies (13 randomized controlled trials, 30 nonrandomized studies) were included in the review. All infants in the studies received appropriate immunoprophylaxis. Among 3656 highly viremic mothers treated with TDF, hepatitis B virus DNA suppression to the levels <200,000 IU/mL at delivery was achieved in 34% to 100% of mothers. MTCT rates were 0 to 5% and 2 to 83% in mothers treated with TDF and in those who received no treatment, respectively. Congenital malformation rates were 0 to 2.1% in the TDF groups, which did not differ from the nontreated groups. Similar findings were reported in 4 studies that enrolled 326 mothers for maternal TAF therapy, resulting in 0% of MTCT and 0% infant malformation. All studies observed that TDF or TAF maternal therapy reduced MTCT rates significantly without safety concerns when compared with untreated groups, except for 1 RCT that failed the therapeutic endpoint.

Conclusions:
TDF is well established for preventing MTCT in highly viremic mothers, whereas TAF may become an option as data emerges.
A Systematic Literature Review of Hispanic Adults’ Experiences With the Emergency Medical Services System in the United States Between 2000 and 2021
Authors: Melgoza Esmeralda , Cardenas Valeria , Enguídanos Susan , Vargas Bustamante Arturo , Beltrán-Sánchez Hiram 
Published: January 2023

Objective:
This systematic literature review presents an overview of studies that assess the experiences of Hispanic adults with (1) activation of emergency medical services (EMS); (2) on-scene care provided by EMS personnel; (3) mode of transport (EMS vs. non-EMS) to an emergency department (ED); and (4) experiences with EMS before and during the COVID-19 pandemic.

Methods:
A bibliographic database search was conducted to identify relevant studies on Ovid MEDLINE (PubMed), Web of Science, EMBASE, and CINAHL. Quantitative, mixed methods, and qualitative studies published in English or Spanish were included if they discussed Hispanic adults’ experiences with EMS in the US between January 1, 2000 and December 31, 2021. The Hawker and colleagues quality assessment instrument was used to evaluate the quality of studies.

Results:
Of the 43 included studies, 13 examined EMS activation, 13 assessed on-scene care, 22 discussed the mode of transport to an ED, and 4 described Hispanic adults’ experiences with EMS during the COVID-19 pandemic. Hispanics were less likely to activate EMS (N=7), less likely to receive certain types of on-scene care (N=6), and less likely to use EMS as the mode of transport to an ED (N=13), compared with non-Hispanic Whites. During the early COVID-19 pandemic period (March to May 2020), EMS use decreased by 26.5% compared with the same months during the previous 4 years.

Conclusions:
The contribution of this study is its attention to Hispanic adults’ experiences with the different phases of the US EMS system.
Correlations between glucose metabolism of bone marrow on 18F-fluoro-D-glucose PET/computed tomography and hematopoietic cell populations in autoimmune diseases
Authors: Zhang Tong , Zhang Jifeng , Wang Hongjia , Li Ping 
Published: January 2023

Purpose
This study aims to investigate which hematopoieticcell populations, clinical factors, and laboratory values are associated with FDG uptake in bone marrow (BM) on FDG PET/CT in patients with autoimmune diseases.

Methods
Forty-six patients with autoimmune disease who underwent FDG PET/CT and BM aspiration (BMA) between 2017 and 2022 were enrolled. The max and mean standard uptake values (SUVmax and SUVmean, SUVs) of FDG in BM, liver, and spleen were measured, and the bone marrow-to-liver SUVs ratios (BLRmax and BLRmean, BLRs) and spleen-to-liver SUVs ratios (SLRmax and SLRmean, SLRs) were calculated. BMA and clinical and laboratory parameters were collected and evaluated for association with BLRs and SLRs.

Results
The patients were divided into the Grade II group (20; 43.5%) and Grade III groups (26; 56.5%) according to hemopoietic activity. The BLRmax (P = 0.021), proportion of granulocytes (P = 0.011), metamyelocytes (P = 0.009), myelocytes (P = 0.024), and monocytes (P = 0.037) in BM were significantly higher in the Grade II group. Multivariate (stepwise) linear regression analyses showed that the proportion of granulocytes in BM was the strongest and only independent factor (P < 0.0001) associated with BLRmax with an adjusted R
2 of 0.431 in model 1. In model 2, ferritin (P = 0.018), CRP (P = 0.025), and the proportion of metamyelocytes (P = 0.043) in BM were correlated with BLRmax with an adjusted R
2 of 0.414.

Conclusion
The FDG uptake in BM is associated with hemopoietic activity and is regulated by hyperplastic granulocytes, particularly immature metamyelocytes, in patients with autoimmune diseases. Glucose metabolism in the BM correlates with the severity of systemic inflammation.
Borderline Personality Disorder
Authors: Restek-Petrovic Branka , Grah Majda , Ivezic Ena , Handl Hrvoje , Milovac Zeljko , Bahun Ivana , Mayer Nina , Vrbek Petra 
Published: January 2023

Abstract
The aim of this study was to compare the effectiveness of two treatment modalities for patients diagnosed with borderline personality disorder (BPD). A total of 100 psychiatric patients diagnosed with BPD participated in this study. Among them, 50 patients were outpatients who attended the Reason and Emotion (RIO) program, and the remaining 50 were inpatients who were treated on psychotherapeutic ward at the same hospital. All the participants filled out the following battery of tests when entering the program/psychotherapy ward and 3 months later: Rosenberg's Self-Esteem Scale, Tennessee Self-Concept Scale (2nd ed), Barratt Impulsiveness Scale, The COPE Inventory, and the WHOQOL-BREF scale. The results showed significant positive effects of both treatment modalities on patients' self-esteem, different domains of self-concept, impulsivity, and different domains of subjective quality of life. No significant changes were observed in terms of coping strategies. Thus, the results speak in favor of the outpatient RIO program, which is more cost-effective than the inpatient ward treatment.
Use of the Endometrial Receptivity Array to Guide Personalized Embryo Transfer After a Failed Transfer Attempt Was Associated With a Lower Cumulative and Per Transfer Live Birth Rate During Donor and Autologous Cycles
Authors: Cozzolino Mauro , Diáz-Gimeno Patricia , Pellicer Antonio , Garrido Nicolas 
Published: January 2023

(Abstracted from Fertil Steril 2022;118(4):724–736)
Although preimplantation genetic testing for aneuploidy increases the likelihood of live birth per embryo transfer in in vitro fertilization, a euploid embryo does not guarantee success. Endometrial factors including timing transfer during the “implantation window” contribute to the likelihood of achieving pregnancy.
Therapeutic Drug Monitoring of Lacosamide: Is 10 to 20 mg/L a Suitable Reference Range for Patients With Epilepsy?
Authors: Otero Torres Sara , Juvany Roig Roser , Falip Centellas Mercè , Casellas Gibert Miriam , Estopiñá Antolí Mónica , Rigo Bonnin Raül , Sala-Padro Jacint Xavier , Jódar Massanés Ramón 
Published: January 2023

Objectives
The reference range for lacosamide (LCM) has been updated from 1 to 10 mg/L to 10 to 20 mg/L. Historically, LCM range was defined from trough-level measurements, but the newer ranges were obtained from peak-level measurements. The purpose of the study was to evaluate the relationship between LCM plasma levels higher than 10 mg/L and the incidence of adverse effects.

Methods
This was a single-center, retrospective, observational study of adult outpatients with epilepsy who were prescribed LCM and had LCM serum concentrations (LCM-SCs) >10 mg/L on drug-fasting samples, measured from June 2017 to December 2020.

Results
A total of 55 LCM-SC samples corresponding to 44 patients (25 women [57%]) were analyzed. The median age was 47 (39–61) years. The median LCM-SC was 13.4 (11.2–17.8) mg/L. Adverse effects were reported in 18 patients (41%). Forty-eight percent (21 of 44) of patients required an LCM dose reduction, with a mean LCM-SC of 16.0 (13.2–18.1) mg/L, whereas, in the remaining patients (23 of 44), LCM dose was not modified, with a mean LCM-SC of 12.2 (10.7–14.2) mg/L (P = 0.0244). Forty-one percent (18 of 44) of patients reported adverse effects related to LCM, with a mean LCM-SC of 15.6 (12.7–18.4) mg/L, whereas, in the remaining patients (26 of 44), adverse effects did not occur, with a mean LCM-SC of 12.6 (10.7–16.5) mg/L (P = 0.0495).

Conclusions
The 10 to 20 mg/L reference range clearly increases toxicity in patients treated with LCM. Adjusting the reference range upper limit to 12 mg/L with a routine therapeutic drug monitoring program is suggested, to achieve a reasonable probability of efficacy and decrease toxicity.
Development of a Suicide Prevention Life Gatekeeper Training Program in China: A Delphi study
Authors: Cai Chengxi , Yin Chen , Tong Yongsheng , Qu Diyang , Ding Yunzhi , Ren Daixi , Chen Peiyu , Yin Yi , An Jing , Chen Runsen 
Published: January 2023

AbstractIntroductionYouth suicide has been a pressing public mental health concern in China, yet there is a lack of localised gatekeeper intervention programs developed for Chinese schools. Life Gatekeeper was the first systematically developed gatekeeper program which aimed to equip teachers and parents with knowledge, skills, and ability to identify and intervene students at high risk of suicide. This study aimed to achieve expert consensus on the content of this program.MethodsThe Delphi method was used to elicit consensus on statements essential to include in the training program. In the form of scoring existing statements and responding to open-ended questions, experts have the opportunity to evaluate the content, delivery form, feasibility, and overall feeling of the initial training program. Two Delphi rounds were conducted among Chinese panel members with diversified professional backgrounds in suicide research and practice. Statements were accepted for inclusion in the adjusted training program if they were endorsed by at least 80% of the panel.ResultsConsensus was achieved on 201 statements out of 207 statements for inclusion in the adapted guidelines for the gatekeeper programme, with 151 from the original questionnaire, and 50 generated from the comments of the panel members. These endorsed statements were used to develop the Life Gatekeeper training program.ConclusionThis Delphi study provided an evidence base in developing of the first gatekeeper training program in China. We hope that the current study could pave the way for more evidence based suicide prevention programs in China. Further study is warranted to evaluate the effectiveness of the Life Gatekeeper training program.
Awareness of cervical cancer and screening in Benin and Cameroon: analysis of the Demographic and Health Survey (DHS)
Authors: Olajide Nike , Jani Bhautesh Dinesh , Niedzwiedz Claire L , Johnman Cathy , Robb Kathryn A. 
Published: January 2023

AbstractCervical cancer incidence and mortality are high in Africa. We assessed cervical cancer and screening awareness in two West African countries.We used data from the Demographic and Health Survey (DHS) in Benin (DHS 2017-2018) and Cameroon (DHS 2018). Women (n=21322) aged 15-49 were interviewed on awareness of cervical cancer and cervical cancer screening. Descriptive statistics and logistic regression analysis were used.Awareness of cervical cancer was low among women in Cameroon (46.1%) and very low in Benin (9.5%). Among those aware of cervical cancer, 51.4% in Benin and 59.7% in Cameroon were also aware of cervical screening. In the adjusted analysis, women in Cameroon aged 45+ had the highest awareness odds of both cervical cancer (adjusted odds ratio-aOR 2.91, [2.36-3.60]) and screening (aOR 1.75, [1.33-2.29]). In Benin, women aged 45+ had the highest cervical cancer awareness (aOR 1.89 [1.23-2.91]) while screening awareness was highest in women aged 25-34 years (aOR 1.98, [1.20-3.27]). Women with higher education were six to nine times more aware of cervical cancer and three to four times more aware of cervical screening than women with no education in Benin and Cameroon respectively. Additionally, cervical cancer awareness was approximately four times higher in the richest wealth quintile in Cameroon. In Benin, the odds of awareness of cervical cancer were increased with daily internet use (aOR 3.61, [2.45-5.32]) and radio listening once a week (aOR 1.73 [1.04-2.88]) compared to no internet and no radio listening respectively. In Cameroon, both awareness of cervical cancer and screening increased with daily internet use (aOR 1.95 [1.61-2.35]) and (aOR 1.35 [1.10-1.67]) respectively.There is a need to increase awareness of cervical cancer and screening in Benin and Cameroon and likely among other West African countries. The internet and radio appear to be important potentially effective means for raising awareness.
Structure of pre-miR-31 reveals an active role in Dicer processing
Authors: Ma Sicong , Kotar Anita , Grote Scott , Rouskin Silvi , Keane Sarah C. 
Published: January 2023

AbstractAs an essential post-transcriptional regulator of gene expression, microRNA (miR) levels must be strictly maintained. The biogenesis of many, but not all, miRs is mediated by trans-acting protein partners through a variety of mechanisms, including remodeling of the RNA structure. miR-31 functions as an oncogene in numerous cancers and interestingly, its biogenesis is not known to be regulated by protein binding partners. Therefore, the intrinsic structural properties of pre-miR-31 can provide a mechanism by which its biogenesis is regulated. We determined the solution structure of the precursor element of miR-31 (pre-miR-31) to investigate the role of distinct structural elements in regulating Dicer processing. We found that the presence or absence of mismatches within the helical stem do not strongly influence Dicer processing of the pre-miR. However, both the apical loop size and structure at the Dicing site are key elements for discrimination by Dicer. Interestingly, our NMR-derived structure reveals the presence of a triplet of base pairs that link the Dicer cleavage site and the apical loop. Mutational analysis in this region suggests that the stability of the junction region strongly influence both Dicer binding and processing. Our results enrich our understanding of the active role that RNA structure plays in regulating Dicer processing which has direct implications for control of gene expression.
Macrophage activation drives ovarian failure and masculinization
Authors: Bravo Paloma , Liu Yulong , Draper Bruce W. , Marlow Florence L. 
Published: January 2023

AbstractIn humans, premature ovarian insufficiency (POI) is caused by autoimmunity and genetic factors, such as mutation of BMP15, a key ovarian determining gene. The cellular mechanisms associated with ovarian failure caused by BMP15 mutation and immune contributions to the disorder are not understood. BMP15’s role in ovarian follicle development is conserved in vertebrates, including zebrafish. Using zebrafish, we established a causal link between macrophage activation and ovarian failure. We identified a germline-somatic gonadal cell-macrophage axis underlying ovarian atresia. Germline loss of Bmp15 triggers this axis that single-cell RNA sequencing and genetic analyses indicate involves activation of ovarian somatic cells that express conserved macrophage-activating ligands. Genetic ablation of macrophages blocks premature oocyte loss. Thus, the axis identified here represents potential therapeutic targets to preserve female fertility.One-Sentence SummarySex reversal due to Bmp15 deficiency requires macrophage activation by Csf1a, which is expressed by specialized pre-follicle cells in zebrafish.