bluuebunny/crossref_metadata_2025_split huggingface dataset:
Green Chemistry Approach for the Synthesis of Isoxazole Derivatives and
Evaluation of their Anti-epileptic Activity
Authors: Panda Krishna Chandra , Varaha Bera Ravi Kumar Venkata , Sahoo Biswa Mohan , Swain Parijat 
Published: February 2023

Background:
Green strategy involves the design, synthesis, processing, and use of chemical
substances by eliminating the generation of chemical hazards. This approach focuses on atom
economy, use of safer solvents or chemicals, consumption of energy, and decomposition of the chemical
substances to non-toxic materials which are eco-friendly.

Objective:
So, the microwave irradiated heating method is considered a green and sustainable technique
for the development of novel heterocyclic scaffold-like isoxazole derivatives via chalcones.
Isoxazole derivatives play a vital role due to their diverse pharmacological activities such as antibiotic
(Sulfamethoxazole, Cloxacillin, Flucloxacillin, Cycloserine), anti-fungal (Drazoxolon), Antirheumatic
(Leflunomide), antidepressant (Isocarboxazid), antineoplastic (Acivicin), anticonvulsant (Zonisamide),
antipsychotic (Risperidone) and anti-inflammatory drugs (Valdecoxib), etc.

Methods:
The isoxazole derivatives were synthesized with the help of microwave irradiation that follows
green chemistry protocol.

Results:
The titled compounds were subjected to antiepileptic evaluation to determine their therapeutic
potential.

Conclusion:
The use of microwave radiation enhances the rate of the reaction which leads to high selectivity
with improved product yields in comparison with the traditional heating methods. The tested
compounds exhibited promising antiepileptic activity as compared to the standard drug (Phenytoin).
A Review of the Effects of the COVID-19 Pandemic on Children and Adolescents’
Mental Health
Authors: Deborah Omoleye Damilola , Olubukola Abidakun Oluwayemisi , Oluwadamilola Akinje Rachael , Hannah Ademuyiwa Oluwaseun , Mofoluwaso Fasogbon Beatrice 
Published: February 2023

Abstract:
Disaster poses a huge threat to physical health as much as mental health, and COVID-19 is not any different. Understanding that physical and social factors can all contribute to mental health disruptions explains the rising concern of the global community about the impacts of COVID-19 on mental health, especially among the vulnerable, including children and adolescents. It is imperative to explore the diverse impacts of COVID-19 on the paediatric age group, especially to better address its effect and adequately strategize for its resulting conditions. This narrative re-view, therefore, explores literature reports on the effect of the pandemic on the mental health of children and adolescents. As observed in the literature, COVID-19 did not only threaten the physi-cal health of children and adolescents but also their mental health, especially in terms of anxiety, depression, sleep alteration, etc. In this paper, we have discussed interventions, such as adequate sleep, healthy lifestyles, and nutritious foods, to improve paediatric mental health even after the pandemic.
Eating and Mealtime Behaviors in Vietnamese Children with Autism
Spectrum Disorder: A Study Using the Brief Autism Mealtime Behaviors
Inventory
Authors: Ha Nguyen Thanh , Trang Do Thi Hanh , Anh Hoang Khac Tuan , Ha Le Thi Thu 
Published: February 2023

Background:
There has been an increase in the number of children with autism
spectrum disorder (ASD), in whom problems with eating behaviors are often present. The use of
a standardized questionnaire to assess the eating behaviors of children with ASD in Vietnam has
not been paid due attention.

Objective:
This study aims to assess eating behaviors in children with ASD aged 3-11 years using
the Brief Autism Mealtime Behaviors Inventory (BAMBI), thereby providing additional evidence
to inform interventions in ASD children in Vietnam.

Methods:
An online survey using the BAMBI was conducted with parents of 85 children with
ASD and parents of 175 typically developing (TD) children between April 2020 and April 2021.

Results:
The study revealed a higher risk of eating behavior problems among children with ASD
compared to TD children (p < 0.0001). The differences between the two groups were statistically
significant in 17 out of 18 items of the BAMBI. The study results also point out that in autistic
children, the scores of 4/8 behaviors in the “limited variety” group were highest, which exceeded
three points, while none of the behaviors relating to “food refusal” or “features of autism”
reached three points.

Conclusion:
Future studies using direct observations with larger samples are needed to further
investigate eating disorders among children with ASD.
Evaluation of the Possible Relationship between the Curvature and
Horizontal Course of the Inferior Alveolar Canal
Authors: Koca Cansu G. , Çiçek M. Fatih , Sadry Sanaz , Yenidünya Ozan , Kaplan Fatma Akkoca , Erdil Aras 
Published: February 2023

Objectives:
The position of the inferior alveolar canal (IAC) and its course in the mandible
is crucial to prevent complications in oral surgical procedures. Therefore, the present study aims to
predict the course of IAC using landmarks specific to the mandible and to correlate with cone-beam
computed tomography images.

Methods:
On the included panoramic radiographs (n=529), the closest point of the IAC to the inferior
border of the mandible (Q) was determined, and the distances of this point to the mental (Mef) and
mandibular foramen (Maf) were measured in millimeters. To determine the buccolingual course of the
IAC on CBCT images (n=529), the distances from the center of the canal to the buccal and lingual
cortices and between the cortices were measured at the level of the root apices of the first and second
premolars and molars. Also, the positions of the Mef to adjacent premolars and molars were classified.

Results:
The most common position of mental foramen was Type-3 (37.1%). On the coronal plane, it
was also observed that as the Q point approaches the Mef, the IAC is located in the mandible's center
at the second premolar level (p=0.008) and moves away from the midline at the level of the first molar
(p=0.007).

Conclusions:
Based on the results, a correlation was observed between the horizontal course of the IAC
and its proximity to the inferior border of the mandible. Therefore, the curvature of the IAC and its
proximity to the mental foramen should be considered in oral surgeries.
Review on Computer Aided Breast Cancer Detection and Diagnosis using
Machine Learning Methods on Mammogram Image
Authors: Kuttan Girija Ottathenggu , Elayidom Mannathazhathu Sudheep 
Published: February 2023

Abstract:
Machine Learning (ML) plays an essential part in the research area of medical image processing.
The advantages of ML techniques lead to more intelligent, accurate, and automatic computeraided
detection (CAD) systems with improved learning capability. In recent years, deep learning-based
ML approaches developed to improve the diagnostic capabilities of CAD systems. This study reviews
image enhancement, ML and DL methods for breast cancer detection and diagnosis using mammogram
images and provides an overview of these methods. The analysis of different ways of ML and
DL shows that the usages of traditional ML approaches are limited. However, DL techniques have an
excellent future for implementing medical image analysis and improving the ability to exist CAD systems.
Despite the significant advancements in deep learning methods for analyzing medical images to
detect breast cancer, challenges still exist regarding data quality, computational cost, and prediction
accuracy.
Multisystem Sarcoidosis Combined with Sjögren's Syndrome: A Case
Report and Literature Review
Authors: Li Xiaoran , Wu Jing , Ruan Guangan , Chen Yu-Chen 
Published: February 2023

Background:
Sarcoidosis is a systemic non-caseous necrotizing granulomatous disease with
unknown etiology. It can involve multiple organs throughout the body, most commonly affecting lungs
and/or bilateral hilar lymph nodes. Sjögren's syndrome is a multi-system autoimmune disease. The
main clinical symptoms include dry mouth and dry eyes. The combination of the two diseases with the
involvement of multiple systems is very rare, and the final diagnosis is mainly based on the comprehensive
judgment of clinical history, imaging manifestations and pathological examination.

Case presentation:
We report a case of multiple sarcoidosis (lung, hilar, mediastinal, inguinal, liver,
and spleen) with Sjögren syndrome. The patient had a dry mouth, dry eyes, and bilateral parotid gland
enlargement. The first computed tomography (CT) scan of the chest and abdomen showed multiple
nodules in the lungs, multiple enlarged lymph nodes, and low-density shadows in the liver and spleen.
After a one-year interval, the re-examination showed that the lung lesions increased with bead-like
changes, and the lymph nodes shrunk. Through pathological puncture and comprehensive judgment,
considering the coexistence of the two diseases, the patient improved after hormone therapy and was
finally diagnosed.

Conclusion:
Multisystem sarcoidosis combined with Sjögren's syndrome has rarely been reported in
the literature. This case has multiple imaging examinations, pathological data and a follow-up review
after treatment. The dynamic changes in different periods will help us to better understand the situation
of sarcoidosis and explore the connection between the two diseases so as to reduce misdiagnosis.
Iron Chelation and Antioxidant Properties of Withania somnifera
(Ashwagandha) Restore Fertility in Men and Women
Authors: Joshi Ruchira , Yadav Pratik , Bagwe-Parab Siddhi , Tuli Hardeep Singh , Buttar Harpal Singh , Kaur Ginpreet 
Published: February 2023

Abstract:
Withania somnifera (Ashwagandha) is one of the most renowned and revered medicinal
plants in the Indian Ayurvedic system of medicine. Ashwagandha Rasayanas (tonics), capsules, tablets,
and powdered herbs (churna) have been used for curing a wide variety of ailments, including
reproductive problems, and for improving fertility in men and women as well as erectile dysfunction
(ED) in men. Iron accumulation in reproductive organs is caused by excessive dietary intake of iron,
dysregulation of iron transporters, chronic blood transfusions, and hemochromatosis. Iron overload
produces oxidative stress and causes atrophy of ovaries and testes and hypogonadism, which leads to
infertility in men and women. Emerging evidence from preclinical and clinical studies suggests that
excessive iron-induced infertility results from dysfunction of the hypothalamic-pituitary-gonadal axis
and consequently perturbs the secretion of sex hormones (GnRH, FSH, LH, estrogen, progesterone,
and testosterone). The focus of this review is to summarize the pathophysiology of iron-overload
toxicity of reproductive organs and the reversal of male/female infertility and libido with Ashwagandha.
The bioactive ingredients of Ashwagandha appear to restore iron–overload infertility by acting
on iron chelation and capturing iron free radicals (Fe+++) produced by the Fenton reaction. Many synthetic
drugs have been tried for treating iron overload infertility, but the outcome has been inconsistent.
Considering the high cost of these drugs, Ashwagandha may be a safer and more costeffective
phytomedicine to cure iron-overload infertility and enhance libido in humans. Collectively,
the iron chelation and antioxidant effects of Ashwagandha seem to reverse iron-overload infertility in
men and women by improving testicular and ovarian functions.
Design of Solid-contact Ion-selective Electrode with Multiwall-carbon
Nanotubes for Assay of Sulfacetamide in Rabbit Aqueous Humour
Authors: Hassan Said A. , Mahmoud Amr M. , Kamel Mona A. , Abbas Samah S. , Michael Adel M. 
Published: February 2023

Background:
Inclusion of multiwall-carbon nanotubes (MWCNTs) as ion-to-electron transducers
within the ionophore-doped PVC membrane has a great impact on the stability and robustness of
the produced sensor performance compared to conventional liquid-based ISEs.

Objective:
Solid-contact ion selective electrodes (SC-ISEs) were fabricated and optimized for the assay of sulfacetamide sodium in both ophthalmic eye drops and in rabbit aqueous humor.

Methods:
2-hydroxypropyl-β-cyclodextrin (2HP-β-CD) was selected as an ionophore to dope the ionselective
membrane to enhance its selectivity towards sulfacetamide. The performance of multiwall-CNTs
as ion-to-electron transducer was evaluated by comparing MWCNT-based SC-ISE with control sensor
which does not include the MWCNTs. The electrochemical performance characteristics of the proposed
sensors were assessed in accordance with the IUPAC recommendations. A green profile assessment of the
proposed method was performed using Eco-Scale and AGREES metrics.

Results:
Inclusion of MWCNT into the sensing membrane improved the performance of the developed
sensor. The linearity range was (2.5 x 10-4 M - 1.0 x 10-2 M) for both sensors and the LOD was estimated
to be 5.6 x 10-5 M for GCE/ISM(CNT) and 1.5x 10-4 M for control sensor GCE/ISM. The results of green
assessment for both the developed and the official method showed an excellent greenness of the proposed
method.

Conclusion:
The proposed sensor can be applied successfully for the determination of sulfacetamide in eye drops and rabbit aqueous humour.
Neuroprotective Effect of Levetiracetam in Combination with Berberine on Scopolamine Induced-Cognitive Impairment in Mice: A Behavioral and Biochemical Approach
Authors: Singh Anuradha , Dhaneshwar Suneela Sunil , Mazumder Avijit , Kumar Swatantra , Saxena Shailendra Kumar 
Published: February 2023

Background:Presently, only four drugs have been approved by FDA for Alzheimer’s disease (AD). A drug repurposing approach can be fruitful in searching for promising candidates for AD.Objective:The objective of the work was to evaluate the neuroprotective effect of levetiracetam (LEV) in combination with berberine (BER) in scopolamine-induced cognitive impairment in mice by applying a drug repositioning approach owing to their antioxidant potential.Methods:Cognitive impairment was induced in mice by scopolamine. Morris water maze, elevated plus maze, and Y-maze were used to evaluate behavioral parameters. Assays for acetylcholinesterase (AChE), reduced glutathione (GSH), malondialdehyde (MDA), catalase, nitrite, TNF-α, and brain histopathology were performed.Results:The transfer latency time and percentage of spontaneous alternation were significantly reduced and significant alterations in AChE and MDA levels, GSH concentration, and improvement in nitrite and catalase levels were also evidenced after the treatment of mice with a combination of LEV and BER in comparison to independent drugs, standard and disease control groups. The antioxidant defense was also improved and TNF-α levels were significantly reduced by a combination of LEV and BER. Improvement in neuronal damage by restoration of the cytoarchitecture of the brain was also seen in the histopathological study of the brain of treatment groups.Conclusion:The present study has demonstrated that the combination of LEV and BER has significantly improved cognition in mice by lipid peroxidation inhibition, augmentation of endogenous antioxidant enzymes, the decline in TNF- α levels, and AChE activity in the brain when compared to individual drugs, standard and disease control owing to their strong antioxidant and anti-inflammatory potentials.
Impact of COVID-19 on Anxiety and Depression - Biopsychosocial
Factors
Authors: Bertollo Amanda Gollo , Leite Galvan Agatha Carina , Dama Mingoti Maiqueli Eduarda , Dallagnol Claudia , Ignácio Zuleide Maria 
Published: February 2023

Abstract:
Anxiety and depression are prevalent mental disorders around the world. The etiology of
both diseases is multifactorial, involving biological and psychological issues. The COVID-19 pandemic
settled in 2020 and culminated in several changes in the routine of individuals around the world, affecting
mental health. People infected with COVID-19 are at greater risk of developing anxiety and
depression, and individuals previously affected by these disorders have worsened the condition. In addition,
individuals diagnosed with anxiety or depression before being affected by COVID-19 developed
the severe illness at higher rates than individuals without mental disorders. This harmful cycle
involves several mechanisms, including systemic hyper-inflammation and neuroinflammation. Furthermore,
the context of the pandemic and some previous psychosocial factors can aggravate or trigger
anxiety and depression. Disorders are also risks for a more severe picture of COVID-19. This review
discusses research on a scientific basis, which brings evidence on biopsychosocial factors from
COVID-19 and the context of the pandemic involved in anxiety and depression disorders.
Restoration of Altered Oncogenic and Tumor Suppressor microRNA
Expression in Breast Cancer and Colorectal Cancer Cell using Epicatechin
Authors: Kiran Sheetal , Patra Abhilipsa , Verma Poonam , Purkait Suvendu , Chhabra Gaurav , Guttula Praveen Kumar , Ghosh Amit 
Published: February 2023

Background:
MicroRNAs (miRNA) are small non-coding RNAs that regulate the function of mRNA post-transcriptionally in a tissue-specific manner. miRNA expressions are heavily dysregulated in human cancer cells through various mechanisms, including epigenetic changes, karyotype abnormalities, and miRNA biogenesis defects. miRNAs may act as either oncogenes or tumor suppressors under different conditions. Epicatechin is a natural compound found in green tea which possesses antioxidant and antitumor properties.

Objective:
The objective of this study is to investigate the effect of epicatechin treatment on the expression level of several oncogenic and tumor suppressor miRNAs in breast and colorectal cancer cell lines (MCF7 and HT-29) and identify its mechanism of action.

Methods:
The MCF-7 and HT29 cells were treated with epicatechin for 24 hours and untreated cells were considered control cultures. miRNA was isolated and qRT-PCR was used to measure the expression profile changes of different oncogenic and tumor suppressor miRNAs. Furthermore, the mRNA expression profile was also screened at different concentrations of epicatechin.

Results:
Our results showed several-fold changes in miRNAs expression level, which is cell line specific. Also, epicatechin at different concentrations induces biphasic changes in mRNA expression levels in both cell lines.

Conclusion:
Our findings first time demonstrated that epicatechin can reverse the expression of these miRNAs and may trigger the cytostatic effect at a lower concentration.
Greener Approaches Towards 1,4–Benzothiazine Synthesis: Recent Updates
and Outlook
Authors: Bhattacharya Suchandra , Basu Basudeb 
Published: February 2023

Abstract:
Heterocyclic moieties are ubiquitous in nature and the exploration of heterocyclic chemistry
goes centuries back, which have coalesced into the invention of greener methodologies towards
the synthesis of heterocycles of potential uses. Benzothiazine is an important class of heterocyclic
molecule, in which a benzene ring is fused with a six–member N, S containing ring.
Amongst the three possible isomers, 1,4–benzothiazines show a wide spectrum of pharmaceutical
and biological activities like anti–inflammatory, anti–rheumatic, antihypertensive, andantipathogenic
roles. In search of greener protocols,metal–free catalysts, and environmentally benign reaction
conditions, a lot have been unboxed to date, and many other dimensions remain yet to be deciphered.
This minireview is an attempt to classify various sustainable protocols for the synthesis
of 1,4–benzothiazine scaffolds over the last decade based on the reacting components and pathways,
along with the consideration of plausible mechanistic insights and critical analysis.
Intelligent Prediction of Photovoltaic Power Generation Considering
Uncertainty Measurement
Authors: Fan Guo-Feng , Ge Qing-Yi , Ren Si-Jie , Hu Shao-Xiang , Hong Wei-Chiang 
Published: February 2023

Background:
As a renewable energy, solar energy has the advantages of being nonpolluting,
clean, and renewable. With the variability of solar radiation, the complexity of meteorological
factors, and other uncertain changes, how to measure its comprehensive uncertainty is very important.

Objective:
The inherent regularity of the uncertainty behavior of photovoltaic power generation is revealed
by the change process of photovoltaic power generation.

Methods:
Using the empirical wavelet transform (EWT), the uncertainty measurement was studied
from the perspective of social physics, and an optimized intelligent prediction model (PSOBOALSTM)
was proposed based on the uncertainty.

Results:
The intelligent prediction model (PSOBOA-LSTM) has a better prediction effect and higher
accuracy than other models, and reveals the internal mechanism of the photovoltaic power generation
system from the perspective of physics and sociology.

Conclusion:
Using the PSOBOA-LSTM model can better facilitate the power dispatching department
to reasonably arrange conventional power generation, coordinate operations and make maintenance
arrangements based on the predicted photovoltaic power generation, and solve problems arising from
the connection between grid dispatching and photovoltaic power generation forecasting.
Potential Oncotherapeutic Effects of Nutraceuticals against Hepatocellular
Carcinoma: Recent Advancements
Authors: Das Arghadip , Das Supravat , Bhattacharya Sanchari , Sur Debjeet , Bose Samrat , Mukherjee Tilottama 
Published: February 2023

Background:
Worldwide, Hepatocellular carcinoma (HCC) is a frequently diagnosed
cancer, having significant variations in its epidemiology. It ranks as the sixth prevailing neoplasm
and is considered the third leading cause of mortality due to cancer. It accounts for 90% of primary
liver cancers. Till date, an effective prevention or treatment is absent except for liver resection,
chemotherapy and a frequently applied drug -sorafenib. Recently, various plant products and
nutraceuticals are found to be effective in the treatment of HCC. ‘Nutraceuticals’ is a term that
brings into light the two giants of health sciences - nutrient and pharmaceutical. Nutraceuticals
provide medical or health benefits and include prevention or treatment of a disease. These are
generally ‘functional foods’, which are whole, or ‘fortified, enriched and enhanced’ in nutritional
value to satisfy the required amount of essential nutrients and to confer health benefits.

Objective:
This study is based on the recent advancements achieved in the field of HCC treatment
using a variety of emerging nutraceuticals that are effective, solely, or act as an adjuvant in its
treatment. Nutraceuticals such as standardized extracts of ginger, fucoidan, curcumin, proanthocyanidins,
epigallocatechin gallate, apigenin and other nutraceuticals are being studied extensively
for their efficacy against HCC along with their proposed mechanism of action or potential
targets for the treatment or prevention of HCC.