bluuebunny/crossref_metadata_2025_split huggingface dataset:
Promoter methylation levels of RASSF1 and ATIC genes are associated with lung cancer in Iranian patients
Authors: Mashayekhi Mahsa , Asadi Milad , Hashemzadeh Shahriar , Vahedi Amir , Shanehbandi Dariush , Al-Omar Ahmad Faris , Akbari Morteza , Raeisi Mortaza 
Published: December 2022

Abstract

Objectives
Epigenetic alterations like methylation of tumor suppressor genes or oncogenes, in respiratory epithelium have been associated with lung cancer. Hypermethylation of genes promoter is an epigenetic event, and is responsible to tumor suppressor genes inactivation as well as oncogenes activation. This study aimed to assess the role of methylation status in promoter of RASSF1 and ATIC genes their potential implication in the pathogenesis of lung tumor in Iranian patients.

Methods
In this study, we collected 100 tissue samples (50 lung cancer tissues and 50 adjacent non-cancerous lung tissues) from Iranian lung cancer patients. The genomic DNA was extracted, and methylation status of both RASSF1 and ATIC genes was investigated by methylation-sensitive high-resolution melting (MS-HRM) assay technique and Real-Time PCR. Cancer Genome Atlas (TCGA) dataset was also analyzed for further validation of the gene’s methylation.

Results
Methylation of RASSF1 gene promoter was significantly higher in lung tumor tissues. However, promoter methylation levels of ATIC gene was significantly lower in lung tumor tissues. These results were additionally confirmed by TCGA analysis. Promoter methylation of both RASSF1 and ATIC genes was significantly associated with lymph node metastasis, and clinical stage of lung cancer. The receiver operating characteristic (ROC) curve analysis indicated a high accuracy of promoter methylation in these genes as a diagnostic biomarker for lung cancer.

Conclusions
Methylation levels of both RASSF1 and ATIC genes promoters were associated with lung cancer pathogenesis in Iranian population, and may be a suitable biomarker for diagnosis and prognosis of lung cancer in early stage of tumorigenesis.
Adolescent medicine training in postgraduate family medicine education: a scoping review
Authors: Tellier Pierre-Paul , Ataman Rebecca , Zaccagnini Marco , Gore Geneviève , Rodriguez Charo 
Published: December 2022

Abstract

Introduction
Adolescents and young adults require age-appropriate healthcare services delivered by clinicians with expertise in adolescent medicine. However, resident family physicians report a low perceived self-efficacy and under-preparedness to deliver adolescent medical care. We conducted a scoping review to map the breadth and depth of the current evidence about adolescent medicine training for family medicine residents.

Content
We followed Arksey and O’Malley’s framework and searched seven electronic databases and key organizations’ webpages from inception to September 2020. Informed by the CanMEDS-FM, we analyzed the extracted data concerning basic document characteristics, competencies and medical topics using numerical and qualitative content analysis.

Summary
We included 41 peer-reviewed articles and six adolescent health competency frameworks (n=47). Most competencies taught in family medicine programs were organized under the roles of family medicine expert (75%), communicator (11.8%), and professional roles (7.9%). Health advocate and leader were rarely included (1.3%), and never scholar.

Outlook
The omission of multiple competency roles in family medicine resident education on adolescents is insufficient for family physicians to deliver optimal care to adolescents. The combined efforts of family medicine stakeholders to address adolescent medicine competency gaps may positively impact the perceived competence reported by family medicine residents.
Unequal allocation of sample/event sizes with considerations of sampling cost for testing equality, non-inferiority/superiority, and equivalence of two Poisson rates
Authors: Luh Wei-Ming , Guo Jiin-Huarng 
Published: December 2022

Abstract
For non-inferiority/superiority and equivalence tests of two Poisson rates, the determination of the required number of sample sizes has been studied but the studies for the number of events to be observed are very limited. To fill the gap, the present study first is aimed toward determining the number of events to be observed for testing non-inferiority/superiority and equivalence of two Poisson rates, respectively. Also, considering the cost for each event, the second purpose is to apply an exhaustive search to find the unequal but optimal allocation of events for each group such that the budget is minimal for a user-specified power level, or the statistical power is maximal for a user-specified budget. Four R Shiny apps were developed to obtain the number of events needed for each group. A simulation study showed the proposed approach to be valid in terms of Type I error and statistical power. A comparison of the proposed approach with extant methods from various disciplines was performed, and an illustrative example of comparing the adverse reactions to the COVID-19 vaccines was demonstrated. By applying the proposed approach, researchers also can estimate the most economical number of subjects or time intervals after determining the number of events.
Hybrid OCSS/RF system employing wavelength division multiplexing and modulation transmitter diversity
Authors: Sachdeva Shippu , Sindhwani Manoj , Kaur Simarpreet , Kumar Abhishek , Adhikari Manoj Singh 
Published: December 2022

Abstract
Inter-satellite optical free space communication enabling radio frequencies (RF) is prevalent nowadays due to high speed, prolonged reach, and improved security. Inter-channel interference is the predominant performance deteriorating limitation in wavelength division multiplexed (WDM) based optical communication-based satellite systems (OCSS). Therefore, in this work, a hybrid 16 × 40 Gbps OCSS system with 10 GHz RF signals is presented employing transmitter diversity. Further, three different arrangements of NRZ, AMI, and NRZ-AMI are investigated in terms of log bit error rate (BER) and signal-to-noise ratio (SNR) over a 30,000 km link distance. Results revealed that the transmitter diversity-based NRZ-AMI arrangement offered the best performance followed by AMI non-transmitter diversity system. The proposed system is flexible, economical, and easy to realize.
Growing the green city: A cognitive ecostylistic analysis of Third Isaiah’s Jerusalem (Isaiah 55–66)
Authors: Vermeulen Karolien 
Published: December 2022

AbstractIn the ancient world, cities served as physical and conceptual containers to separate a controlled, orderly area from the chaos outside. The depictions of cities in the Hebrew Bible largely underwrite this paradigm. Third Isaiah’s vision of Jerusalem, however, imagines a space that challenges these engrained ideas of the urban. Conducting a cognitive ecostylistic analysis and drawing on insights from Conceptual Metaphor Theory and Text World Theory, this article examines the green city as imagined by Third Isaiah (Isaiah 56–66). Throughout the vision, the prophet creates a new (text-) world defined by urban and natural world-builders, a blend that unites seemingly paradoxical elements. The utopian character of future Jerusalem is downplayed by its grounding in the real world (both the discourse-world and its near-equivalent, the empty text-world in which the prophecy is uttered). Third Isaiah calls for a view of city space that draws on the known, dissolving existing dichotomies and categories. As such, it invites modern readers to rethink not only the biblical Jerusalem but also urban space and its relationship to nature more generally.
A new targetry system for production of zirconium-89 radioisotope with Cyclone-30 cyclotron
Authors: Feizi Shahzad , Fazaeli Yousef , Ashtari Parviz , Shirmardi Seyed Pezhman , Yousefnia Hasan , Aslani Gholamreza 
Published: December 2022

Abstract
In this study, an efficient method for targetry and production of zirconium-89 radioisotope (89Zr) with Cyclone-30 cyclotron was developed. The preparation of a highly pure compressed yttrium oxide target material and design of a target made by copper for better heat transfer was performed. Electrodeposition of target with gold was done to prevent the entry of metallic impurities (copper, zinc and other trace metal elements). Nuclear reaction cross sections for optimization of production with new target and irradiation parameters of the target were evaluated. The prepared 89Zr in the form of [89Zr] Zr-oxalate had high radionuclidic purity (>99.9%) and a low chemical impurity concentration (<0.1 ppm for copper and zinc elements). The yield of 89Zr radioisotope production via the reaction of 89Y(p,n)89Zr was measured to be 77 ± 9.5 MBq/μAh (time of irradiation = 3, the current 20–30 µA). [89Zr] Zr-oxalate specific-activity was in the range 2.319641 × 104–3.479443 × 104 MBq/mmol of Oxalate.
Control mechanism of secondary flow in a turbine cascade with non-axisymmetric endwall profiling under Co-rotating incoming vortex
Authors: Cao Zhiyuan , Wang Chuxuan , Zhao Jiantong , Hao Xinyu , Song Zhigao , Liu Bo 
Published: December 2022

Abstract
Upstream vortex has a significant effect on the secondary flow structure of the downstream turbine in the stage environment. This study investigates the secondary flow structure with non-axisymmetric endwall profiling (NAEW) under the interaction of co-rotating incoming vortex (Vic). A half-delta wing vortex generator is utilized to model Vic. The turbine cascade case which exhibited maximum reduction of the cascade loss with NAEW under no incoming vortex is studied. The mechanism of loss reduction with NAEW under the interaction of Vic is analysed. Vic could decrease the secondary flow near the endwall region by affecting the horseshoe vortex transport in the cascade. However, its loss reduction was lower than the loss increments of Vic itself. The arrival of Vic at the leading edge of the cascade increased the strength of the horseshoe vortex, resulting in a significant increase in loss. Under the interaction of Vic, NAEW decreased the blade loading near endwall region, which resulted in the reduction of cascade loss.
Academic Cheating in Pesantren: How Self Efficacy, Religiosity, and Academic Integrity Predict Academic Cheating
Authors: Lestari Wahidah Iskar , Latifa Rena , Rahmah Muthia 
Published: December 2022

AbstractThis research aims to determine the effect of self-efficacy, religiosity and academic integrity on academic cheating in Pesantren. The population of the research is consisted of students MA. Sample are 332 students and sampling technique is carried out using probability sampling, namely purposive sampling technique. The instrument used were ACS (Academic Cheating Scale), GSE (General Self Efficacy), DUREL (Duke Religion Index), and AIS (Academic Integrity Scale). Data analysis used in this study is multiple linear regression techniques and for the analysis of the construct validity used to measure instrument is Confimatory Factor Analysis CFA. The results of the study show that the effect of the variables of self-efficacy, the dimensions of organizational and dimensions intrinsic to academic cheating which was moderated by academic integrity are significant. Based on the results of the multiple linear regression with academic integrity as the moderator variable, shows that academic integrity has a significant effect or influence on academic cheating and also has a significant influence in moderating one independent variable, namely the organizational dimension to academic cheating. AbstrakPenelitian ini bertujuan untuk mengetahui pengaruh efikasi diri, religiusitas dan integritas akademik terhadap kecurangan akademik di Pesantren. Populasi dalam penelitian ini adalah mahasiswa MA. Sampel berjumlah 332 siswa dan teknik pengambilan sampel dilakukan dengan teknik probability sampling yaitu teknik purposive sampling. Instrumen yang digunakan adalah ACS (Academic Cheating Scale), GSE (General Self Efficacy), DUREL (Duke Religion Index), dan AIS (Academic Integrity Scale). Analisis data yang digunakan dalam penelitian ini adalah teknik regresi linier berganda dan untuk analisis validitas konstruk yang digunakan untuk mengukur instrumen adalah Confimatory Factor Analysis CFA. Hasil penelitian menunjukkan bahwa pengaruh variabel efikasi diri, dimensi organisasi dan dimensi intrinsik terhadap kecurangan akademik yang dimoderatori oleh integritas akademik adalah signifikan. Berdasarkan hasil regresi linier berganda dengan variabel moderator integritas akademik, menunjukkan bahwa integritas akademik berpengaruh atau berpengaruh signifikan terhadap kecurangan akademik dan juga memiliki pengaruh signifikan dalam memoderasi salah satu variabel independen yaitu dimensi organisasi terhadap kecurangan akademik.How to Cite Lestari, W. I., Latifa, R. Rahmah, M. (2022). Academic Cheating in Pesantren: How Self Efficacy, Religiosity, and Academic Integrity Predict Academic Cheating. TARBIYA: Journal of Education in Muslim Society, 9(2), 1-18. doi:10.15408/tjems.v9i1.24701.
Pattern recognition: the effect of exercise performance modes on the effectiveness of teaching the vault to 8-year-old boys
Authors: Rukavytsia Volodymyr , Ivashchenko Olha , Khudolii Oleg , Yermakova Tetiana , Iermakov Sergii 
Published: December 2022

Background and Study Aim. The study purpose was to determine the effect of exercise performance modes on the effectiveness of teaching the vault to 8-year-old boys.
Materials and methods. The study participants were 32 boys aged 8 who were divided into 4 groups of 8 pesons. The children and their parents were informed about all the features of the study and gave their consent to participate in the experiment. The pedagogical experiment investigated the effect of the number of sets (х1), the number of repetitions in a set (х2), and a 60-second rest time on the change in the gain in the level of proficiency of 8-year-old boys in straddle vault over the buck. A method of algorithmic instructions was used in the training. The participants proceeded to the next exercise after three successful attempts.
Results. Statistical analysis of the significance of the discriminant functions showed that the first function explains 81.2% of the data variation and has a high canonical correlation value (r = 0.751). The first function has a high discriminative ability (λ = 0.332, p < 0.021) and can be used to classify the modes of physical exercise performance in the process of formation of motor skills.
Conclusions. The use of multivariate statistics makes it possible to determine the structure of the training program, confirm the effectiveness of the selection of motor tasks, and classify the modes of physical exercise performance during the training process. The best mode of physical exercise performance in teaching the vault to 8-year-old boys is 12 sets of 3 repetitions with a rest time of 60 seconds.
OUTPUT CONTROLLABILITY OF DELAYED CONTROL SYSTEMS IN A LONG TIME HORIZON
Authors: Ananyev Boris I. 
Published: December 2022

In this paper, we consider the output controllability of finite-dimensional control systems governed by a distributed delayed control. For systems with ordinary controls, this problem was investigated earlier. Nevertheless, in many practical and technical problems the control acts with some delay. We give the necessary and sufficient condition for the output controllability. The main goal of our control is to govern the output of the system to some position on a subspace in a given instant, and then keep this output fixed for the remaining times. This property is called the long-time output controllability. For this, sufficient conditions are given. The introduced notions are applied for the investigation of averaged controllability of systems with delayed controls. The general approach for that is to approximate the system by the ordinary ones. Some examples are considered.
ON ONE INEQUALITY OF DIFFERENT METRICS FOR TRIGONOMETRIC POLYNOMIALS
Authors: Arestov Vitalii V. , Deikalova Marina V. 
Published: December 2022

We study the sharp inequality between the uniform norm and \(L^p(0,\pi/2)\)-norm of polynomials in the system \(\mathscr{C}=\{\cos (2k+1)x\}_{k=0}^\infty\) of cosines with odd harmonics. We investigate the limit behavior of the best constant in this inequality with respect to the order \(n\) of polynomials as \(n\to\infty\) and provide a characterization of the extremal polynomial in the inequality for a fixed order of polynomials.
A QUADRUPLE INTEGRAL INVOLVING THE EXPONENTIAL LOGARITHM OF QUOTIENT RADICALS IN TERMS OF THE HURWITZ-LERCH ZETA FUNCTION
Authors: Reynolds Robert , Stauffer Allan 
Published: December 2022

With a possible connection to integrals used in General Relativity, we used our contour integral method to write a closed form solution for a quadruple integral involving exponential functions and logarithm of quotient radicals. Almost all Hurwitz–Lerch Zeta functions have an asymmetrical zero distribution. All the results in this work are new.
АРХАИЗАЦИЯ КАК СОЦИОКУЛЬТУРНЫЙ ФЕНОМЕН СОВРЕМЕННОГО РОССИЙСКОГО ОБЩЕСТВА
Authors: Комиссаров Сергей Николаевич 
Published: December 2022

Целью исследования в представленной статье является социально-философская рефлексия социокультурного феномена архаизации.
Методологию исследования составляет социокультурный подход, позволяющий исследовать архаизацию в пространстве социальных и культурных смыслов. В то же время, обращаясь к отечественной социально-философской мысли изучения архаизации, автор статьи приходит к выводу о необходимости использования системного анализа для рассмотрения данного социокультурного феномена.
Результат исследования состоит в том, что архаизация не является социокультурным феноменом тождественного современности, поскольку оно содержит в себе локальные и региональные интенции. Вместе с тем архаизация характеризуется различными архаическими практиками в социальных, экономических и культурных сферах общества. Также, признавая негативный эффект архаизации для современного российского общества в контексте социальной консолидации, автор статьи делает вывод об ограничивающем использовании архаизации на уровне локальных социокультурных пространств.
Перспектива исследования связана с дальнейшим осмыслением архаизации как схемы социальной и культурной практики в пространстве современного российского общества.
СИСТЕМА РАССЕЛЕНИЯ ЧУВАШСКОЙ РЕСПУБЛИКИ: ЧЕБОКСАРСКАЯ АГЛОМЕРАЦИЯ
Authors: Ситковский Арсений Михайлович 
Published: December 2022

Целью исследования является выявление закономерностей трансформации системы расселения Чувашии с акцентом на Чебоксарскую агломерацию.
Методологическую базу исследования составляют общелогические методы, методы исследования статистики, геоинформационные методы (построение картограмм, изохрон). Источниками данных выступили данные ЕМИСС, Росстата, Чувашстата, краеведческие источники, данные «Всероссийской переписи населения-2010» и оценочные данные о численности населения в населённых пунктах за 2020 год.
Результаты исследования включают обзор социально-экономического положения Чувашской Республики в контексте сопредельных территорий, геоинформационное моделирование системы расселения территории, выделение точек притяжения и зон агломерационного эффекта, анализ структуры расселения, определение границ агломерации двумя методами: декларативным (административным) и экономгеографическим (построения изохрон), определены перечни населённых пунктов и муниципальных образований для обоих случаев, вычислена численность населения агломерации, её динамика с 2010 по 2020 годы, произведены сравнения агломераций, рассчитанных двумя методами, определены основные тенденции трансформации системы расселения Чувашии, угрозы и перспективы.
Перспективы исследования заключаются в использовании полученных материалов в государственном и муниципальном управлении, в том числе при реализации государственной демографической политики в области развития агломераций, реализации «Стратегии пространственного развития Российской Федерации до 2025 года» и Стратегии «Агрессивного развития инфраструктуры».
ТЕМПОРАЛЬНОСТЬ РЕПРЕЗЕНТАТИВНОЙ КУЛЬТУРЫ
Authors: Снежко Галина Евгеньевна 
Published: December 2022

Целью исследования является концепция репрезентативной культуры как основы социологии культуры.
Методологическую базу исследования представляет собой подход, объединяющий смысл и темпоральность, поскольку время — это форма не только объективно протекающих процессов, но и форма, выражающая наши представления о них через память (воспоминание о прошлом), созерцание настоящего и предвосхищение будущего. Устанавливается связь интересов и ценностей человека со временем, которое он отводит на различные действия и активности. В связи с этим исследуются темпоральные характеристики репрезентативной культуры.
Результаты исследования. Полистилизм современной культуры является репрезентацией (осознанной или неосознанной) в жизненных практиках и жизненных стилях ценностных ориентаций на смысловую модальность времени: на настоящее, прошлое или будущее.
Перспективу исследования составляет изучение конкретных инструментов и аспектов, что является, своего рода, отражением тенденций нынешнего времени, которые в ходе развития общества ожидают изменение жизненного стиля в различных социумах.
«ЧЕЛОВЕК ПЕРЕВОПЛОЩАЮЩИЙСЯ» В КОНТЕКСТАХ ЕВРОПЕЙСКОЙ ГУМАНИТАРНОЙ МЫСЛИ
Authors: Бараниченко Наталья Васильевна , Голиусова Ирина Владимировна 
Published: December 2022

Целью исследования является обзор основных теорий и концептов в изучении человека перевоплощающегося, позволяющий выявить ключевую линию, проходящую от описания и само описание в категориях богемы к научным исследованиям.
Результаты исследования. Философско-антропологический фокус исследования коллективного субъекта перформанса эксплицировал базовую дилемму в трактовке игры и перевоплощения, заключающуюся в удвоении реальности и наделении игры статусом вторичности. Пары противоречий серьезное и смешное, естественное и искусственное, реальность и иллюзия закрепляют за человеком перевоплощающимся статус онтологической неполноты, что делает его изучение проблематичным. Возможный выход из указанной дилеммы и реабилитация субъекта перформанса раскрывается в открытии связи игры с концептом жизни (Б. Массуми), а также с концептами сообщества (А. Бадью) и субкультуры. В этом случае человек перевоплощающийся может быть соотнесен с субъектом истины, а также коллективным субъектом и сообществом, возникающим через производство перформанса.
Перспективы исследования. Предлагаемая методологическая и концептуальная связка дает возможность позитивного осмысления как самого феномена игры, так и более полного анализа самого человека перевоплощающегося и актерской субкультуры, взятых в своем феноменальном и деятельностном измерении.
АРТ-ЖУРНАЛИСТИКА В АСПЕКТЕ МЕДИАТИЗАЦИИ КУЛЬТУРЫ: ПРОБЛЕМНАЯ ПАРАДИГМА
Authors: Сорокина Татьяна Евгеньевна 
Published: December 2022

В статье рассматриваются проблемы развития арт-журналистики в условиях медиатизации современного общества.
Цель статьи — определить основные функции арт-журналистики и ее роль в медиатизации искусства и коммуникативных процессов, продуцируемых массмедиа.
Методологическую базу исследования представляет собой комплекс методов: метод наблюдения, индуктивно-дедуктивный метод, метод анализа и синтеза, метод моделирования.
Результаты исследования. В процессе исследования установлены те факторы, которые обусловливают развитие искусства в аспекте медиатизации: массовое тиражирование репродукций, лишающее вещи, окружающие человека, уникальности; изменение дистанции, отделяющей зрителя от арт-объекта, что связано с доступностью информация через интернет; совершенствование технических характеристик медиасредств. Очевидно, что эти же факторы оказывают влияние и на арт-журналистику. Жанровая специфика арт-журналистики характеризуется равноправным положением информационных и аналитических жанров, художественно-публицистические жанры также остаются в ее поле.