bluuebunny/crossref_metadata_2025_split huggingface dataset:
Visuo‐spatial processing is linked to cortical glutamate dynamics in Parkinson's disease — a 7‐T functional magnetic resonance spectroscopy study
Authors: Ophey Anja , Farrher Ezequiel , Pagel Nora , Seger Aline , Doppler Christopher E. J. , Shah N. Jon , Kalbe Elke , Fink Gereon R. , Sommerauer Michael 
Published: April 2023

AbstractBackground and purposeCognitive decline is a frequent and debilitating non‐motor symptom for patients with Parkinson's disease (PD). Metabolic alterations in the occipital cortex during visual processing may serve as a biomarker for cognitive decline in patients with PD.MethodsSixteen patients with PD (Unified Parkinson's Disease Rating Scale Part 3, OFF, 38.69 ± 17.25) and 10 age‐ and sex‐matched healthy controls (HC) underwent 7‐T functional magnetic resonance spectroscopy (MRS) utilizing a visual checkerboard stimulation. Glutamate metabolite levels during rest versus stimulation were compared. Furthermore, correlates of the functional MRS response with performance in visuo‐cognitive tests were investigated.ResultsNo differences in static MRS between patients with PD and HC were detected, but a dynamic glutamate response was observed in functional MRS in HC upon visual stimulation, which was blunted in patients with PD (F1,22 = 7.13, p = 0.014;  = 0.245). A diminished glutamate response correlated with poorer performance in the Benton Judgment of Line Orientation test in PD (r = −0.57, p = 0.020).ConclusionsOur results indicate that functional MRS captures even subtle differences in neural processing linked to the behavioral performance, which would have been missed by conventional, static MRS. Functional MRS thus represents a promising tool for studying molecular alterations at high sensitivity. Its prognostic potential should be evaluated in longitudinal studies, prospectively contributing to earlier diagnosis and individual treatment decisions.
The acceptability and preliminary effectiveness of a brief, online parenting program: Expanding access to Evidence‐Based parenting intervention content
Authors: Holtrop Kendal , Casaburo Gianna , Hickman Tanner , Yzaguirre Melissa M. , Young Deja 
Published: April 2023

AbstractParenting interventions are a promising means for preventing and treating a variety of child behavior and conduct problems; yet, many families lack access to such services. Online parenting programs offer an opportunity to mitigate many barriers to intervention access by extending service delivery options. The purpose of the present study was to evaluate the acceptability and preliminary effectiveness of a brief, online parenting program. We developed a new online parenting program based on foundational content from the evidence‐based GenerationPMTO intervention and used a mixed‐methods, single‐arm open trial (pre–post) design to perform a preliminary evaluation. The combined results from the quantitative and qualitative data provide initial support for the acceptability and preliminary effectiveness of the online program, based on participant self‐report data from program completers. Participants indicated high levels of acceptability for the program topics and videos. They also reported statistically significant improvements from baseline to 4 weeks postintervention in parental efficacy, parenting practices, and child behavior problems. The qualitative data corroborated and expanded these findings. We go on to discuss important accessibility and sustainability considerations addressed by this online parenting program as well as to suggest implications for intervention research and mental health practice.
FTY‐720 alleviates diabetes‐induced liver injury by inhibiting oxidative stress and inflammation
Authors: Ye Huijing , Sun Mengyao , Jin Zijie , Yuan Yan , Weng Hongbo 
Published: April 2023

AbstractWe aimed to investigate the protective effect of FTY‐720 on liver injury and explore its potential mechanism in diabetic mice. The diabetic mouse model was induced with streptozotocin and FTY‐720 was administered for 12 weeks. We assayed biocharacters and liver function and used histopathology staining to evaluate the protective effects of FTY‐720 against diabetic liver injury. Levels of oxidative stress and inflammation in the liver were observed. mRNA and protein levels of essential enzymes for glucose metabolism were quantified in the liver and the protein expression of TLR4, HIF1α and NF‐κB was determined. In vivo results revealed that FTY‐720 significantly lowered blood glucose and lipids and improved liver function and alleviated liver fibrosis in diabetic mice. FTY‐720 reduced oxidative stress and inflammation, with the increased catalase activity and reduced levels of malondialdehyde, myeloperoxidase, IL‐1β, IL‐6, TNF‐α, TGF‐β, and MCP1. Furthermore, FTY‐720 modulated glucose metabolism in liver and elevated the ATP production, showing the promotion of glycogenesis and glycolysis and inhibition of gluconeogenesis. Moreover, FTY‐720 inhibited the expression of TLR4 and HIF1α, contributing to restoration of liver function. In conclusion, FTY‐720 ameliorates diabetes‐induced liver injury and improves glucose homeostasis by inhibiting oxidative stress and inflammation and may be a promise drug for treatment of liver disease.
Advances in the phytochemical screening and biological potential of propolis
Authors: de Almeida‐Junior Silvio , Ferraz Matheus Vitor Ferreira , de Oliveira Alex Roberto , Maniglia Fabíola Pansani , Bastos Jairo Kenupp , Furtado Ricardo Andrade 
Published: April 2023

AbstractPropolis is a natural resinous product collected from different parts of plants by bees and mixed with their salivary secretions. The occurrence of more than 180 different chemotypes has flavonoids, phenolic acids, esters, and phenolic aldehydes, as well as balsamic resins, beeswax, pollen, and essential and aromatic oils, among others. Its biological potential documented throughout the world justifies the need, from time to time, to organize reviews on the subject, with the intention of gathering and informing about the update on propolis. In this review (CRD42020212971), phytochemical advances, in vitro, in vivo, and clinical biological assays of pharmacological interest are showcased. The focus of this work is to present propolis clinical safety assays, antitumor, analgesic, antioxidant, anti‐inflammatory, and antimicrobial activities. This literature review highlights propolis' promising biological activity, as it also suggests that studies associating propolis with nanotechnology should be further explored for enhanced bioprocessing applications.
Global variations and controlling factors of anammox rates
Authors: Yao Yanzhong , Han Bingbing , Liu Bin , Wang Yini , Su Xiaoxuan , Ma Lihua , Zhang Tong , Niu Shuli , Chen Xinping , Li Zhaolei 
Published: April 2023

AbstractSoil anammox is an environmentally friendly way to eliminate reactive nitrogen (N) without generating nitrous oxide. Nevertheless, the current earth system models have not incorporated the anammox due to the lack of parameters in anammox rates on a global scale, limiting the accurate projection for N cycling. A global synthesis with 1212 observations from 89 peer‐reviewed papers showed that the average anammox rate was 1.60 ± 0.17 nmol N g−1 h−1 in terrestrial ecosystems, with significant variations across different ecosystems. Wetlands exhibited the highest rate (2.17 ± 0.31 nmol N g−1 h−1), followed by croplands at 1.02 ± 0.09 nmol N g−1 h−1. The lowest anammox rates were observed in forests and grasslands. The anammox rates were positively correlated with the mean annual temperature, mean annual precipitation, soil moisture, organic carbon (C), total N, as well as nitrite and ammonium concentrations, but negatively with the soil C:N ratio. Structural equation models revealed that the geographical variations in anammox rates were primarily influenced by the N contents (such as nitrite and ammonium) and abundance of anammox bacteria, which collectively accounted for 42% of the observed variance. Furthermore, the abundance of anammox bacteria was well simulated by the mean annual precipitation, soil moisture, and ammonium concentrations, and 51% variance of the anammox bacteria was accounted for. The key controlling factors for soil anammox rates differed from ecosystem type, for example, organic C, total N, and ammonium contents in croplands, versus soil C:N ratio and nitrite concentrations in wetlands. The controlling factors in soil anammox rate identified by this study are useful to construct an accurate anammox module for N cycling in earth system models.
The significance of feminist infrastructure: #MeToo in the construction industry and the green industry in Sweden
Authors: Hansson Karin , Ganetz Hillevi , Sveningsson Malin 
Published: April 2023

AbstractTo better understand the interplay between digital activism and feminist infrastructure, this study investigates #MeToo activism in the Swedish construction industry and green industry. Both are industries in transition characterized by a dissonance between formal incentives, that encourage women and others to work in environments previously dominated by white men, and the informal power structures hosting a toxic masculinity. Based on media texts and interviews with key persons from the industries, the article situates #MeToo in a local context and shows how it was embedded in a supportive social, cultural, and technical infrastructure. In both industries, at the time of #MeToo this feminist infrastructure was already in place consisting of: an awareness of the problem of sexual harassment and abuse, knowledge of feminist explanatory models, established feminist online networks, and a supportive feminist culture, which together with widespread digital and feminist literacy became instrumental in the organization of the movement. Social media connected activists and created a critical mass by supporting the uniting of conflicting identity positions around shared differences. The established feminist infrastructure meant that the #MeToo activism, by articulating a widespread affective dissonance, pushed open doors that were already half open and forced them wide. This can explain some of the movement's success in Sweden.
Determinants of using online mode of teaching: Evidence from higher educational institutions
Authors: Bag Sudin , Sinha Abhijit , Aich Payel 
Published: April 2023

AbstractThe investigation looks at the intention of teachers in higher educational institutions towards online teaching–learning methods using the extended unified theory of acceptance and use of technology. In the aftermath of Covid‐19, the education sector was in shambles, and it was impossible to continue with the traditional offline form, which forced a sudden transition to the online mode of teaching and learning. Thus, it is immensely important to identify the various factors that determine the intention to use the online teaching method by the facilitators of higher education. The present contributions have failed to provide a complete framework towards technological adaptation in higher learning. The approach taken by the researchers is a holistic one as it considers concrete aspects not considered in the previous literature. For this purpose, responses are collected from 240 faculty members of higher education institutions using the online survey method with the help of a structured research questionnaire. The scale of the items was adopted from the existing literature and modified to fit the research objectives. After testing for the outliers and reliability, 231 samples are finally considered. The partial least square structural equation modelling method is employed to test and validate the proposed model. Results of the study show that performance expectation, self‐efficacy, social influence and facilitating conditions have a significant influence on the teachers’ intention towards the use of the online teaching–learning method, which leads to the actual use of this ICT‐based teaching–learning method. In addition, the study highlights that the age of teachers has a negative but significant influence on the intention to use, and discipline has a positive effect. Nevertheless, the institutional level has a negative and significant influence on teachers’ actual use of online teaching–learning methods. The findings can help to design strategies for teaching–learning in recent times.
RETRACTED: Knee and hip arthroplasty joint surgical site wound infection in end‐stage renal disease subjects who underwent dialysis or a kidney transplant: A meta‐analysis
Authors: Luo Yankun , Gong Junfeng , Yang Shuyuan 
Published: April 2023

AbstractA meta‐analysis study to assess the knee and hip arthroplasty joint surgical site wound infection (SSWI) in end‐stage renal disease (ESRD) subjects who underwent dialysis or a kidney transplant (KT). A comprehensive literature examination till February 2023 was implemented and 1046 linked studies were appraised. The picked studies contained 5 471 898 subjects with total joint arthroplasty (TJA) at the baseline, 13 049 of them were haemodialysis or renal transplant, and 5 458 849 were control. Odds ratio (OR) in addition to 95% confidence intervals (CIs) were used to calculate the consequence of knee and hip arthroplasty SSWI in ESRD subjects who underwent dialysis or a KT by the dichotomous and continuous styles and a fixed or random model. Haemodialysis or renal transplant had a significantly higher postoperative SSWI (OR, 2.13; 95% CI, 1.73–2.62, P < .001) compared with control in TJA subjects. However, no significant difference was observed between haemodialysis and renal transplant in postoperative SSWI (OR, 0.93; 95% CI, 0.16–5.54, P = .94) and between haemodialysis or renal transplant and control in prosthetic joint infection (OR, 1.07; 95% CI, 0.25–4.55, P = .93) in TJA subjects. Haemodialysis had a significantly higher prosthetic joint infection (OR, 1.92; 95% CI, 1.21–3.03, P = .005) compared with renal transplant in TJA subjects. Haemodialysis or renal transplant had a significantly higher postoperative SSWI in TJA subjects. Also, haemodialysis had a significantly higher prosthetic joint infection compared with renal transplant in TJA subjects. Although precautions should be taken when commerce with the consequences because a low number of selected studies was picked for certain comparisons in this meta‐analysis.
Instrumental learning and behavioral persistence in children with attention‐deficit/hyperactivity‐disorder: does reinforcement frequency matter?
Authors: Hulsbosch An‐Katrien , Beckers Tom , De Meyer Hasse , Danckaerts Marina , Van Liefferinge Dagmar , Tripp Gail , Van der Oord Saskia 
Published: April 2023

BackgroundProminent theoretical accounts of attention‐deficit/hyperactivity‐disorder (ADHD) hypothesize that reinforcement learning deficits underlie symptoms of ADHD. The Dynamic Developmental Theory and the Dopamine Transfer Deficit hypothesis assume impairments in both the acquisition and extinction of behavior, especially when learning occurs under partial (non‐continuous) reinforcement, and subsequently the Partial Reinforcement Extinction Effect (PREE). Few studies have evaluated instrumental learning in ADHD and the results are inconsistent. The current study investigates instrumental learning under partial and continuous reinforcement schedules and subsequent behavioral persistence when reinforcement is withheld (extinction) in children with and without ADHD.MethodsLarge well‐defined samples of children with ADHD (n = 93) and typically developing (TD) children (n = 73) completed a simple instrumental learning task. The children completed acquisition under continuous (100%) or partial (20%) reinforcement, followed by a 4‐min extinction phase. Two‐way (diagnosis by condition) ANOVAs evaluated responses needed to reach the learning criterion during acquisition, and target and total responses during extinction.ResultsChildren with ADHD required more trials to reach criterion compared to TD children under both continuous and partial reinforcement. After partial reinforcement, children with ADHD executed fewer target responses during extinction than TD children. Children with ADHD executed more responses than TD children during extinction, irrespective of learning condition.ConclusionsThe findings demonstrate general difficulties in instrumental learning in ADHD, that is, slower learning irrespective of reinforcement schedule. They also show faster extinction following learning under partial reinforcement in those with ADHD, that is, a diminished PREE. Children with ADHD executed more responses during extinction. Results are theoretically important, with clinical implications for understanding and managing learning difficulties in those with ADHD, as they suggest poorer reinforcement learning and lower behavioral persistence.
Independent risk factors of rapid glomerular filtration rate decline in patients with type 2 diabetes with preserved kidney function and normoalbuminuria: A multicenter cohort study
Authors: Hirano Daishi , Unoki‐Kubota Hiroyuki , Imasawa Toshiyuki , Yamamoto‐Honda Ritsuko , Kajio Hiroshi , Yamashita Shigeo , Fukazawa Yuka , Seki Naoto , Noda Mitsuhiko , Kaburagi Yasushi 
Published: April 2023

AbstractAims/IntroductionResearch on the incidence and underlying mechanisms of rapid renal function decline in patients with type 2 diabetes mellitus with preserved renal function and normoalbuminuria is limited. This study aimed to investigate the involvement of hemoglobin level as a risk factor for rapid decliners among patients with type 2 diabetes with preserved renal function and normoalbuminuria.Materials and MethodsThis was a retrospective observational study of 242 patients with type 2 diabetes with a baseline estimated glomerular filtration rate of ≥60 mL/min/1.73 m2 and normoalbuminuria (<30 mg/gCr), followed up for >1 year. The annual rate of estimated glomerular filtration rate decline during the follow‐up period was calculated using least square regression analysis; rapid decliners defined at ≥3.3%/year. Risk factors associated with rapid decliners were identified using a logistic regression analysis of variables previously identified as risk factors of rapid decliners.ResultsThe median follow‐up period was 6.7 years, and 34 patients showed rapid decliners. On multivariate analysis, lower baseline hemoglobin level was a risk factor of rapid decliners (odds ratio 0.69, 95% confidence interval 0.47–0.99; P = 0.045). Furthermore, the baseline hemoglobin levels were correlated positively with iron and ferritin levels, implying that an impaired iron metabolism might cause lower hemoglobin levels in rapid decliners.ConclusionsIn patients with type 2 diabetes with preserved renal function and normoalbuminuria, lower hemoglobin levels were a risk factor for rapid decliners, where disturbed iron metabolism might precede the development of diabetic kidney disease.
Molecular identification and first morphological description of theColoradosnapperLutjanus colorado(Perciformes: Lutjanidae) larvae
Authors: Domínguez‐Contreras José Francisco , Jiménez‐Rosenberg Sylvia Patricia Adelheid , Reguera‐Rouzaud Nicole , Sánchez‐Velasco Laura , Díaz‐Viloria Noé 
Published: April 2023

AbstractThis research study obtained the first morphological description of the Colorado snapper (Lutjanus colorado) larvae assisted by DNA barcoding as a molecular identification tool. Sixteen Lutjanidae larvae were separated from zooplankton samples and selected for this study. A fragment of the mitochondrial gene cytochrome oxidase subunit I (COI) of 658 bp was used in the analyses of intra‐ and interspecific genetic divergences; a neighbour‐joining tree (NJ) of K2P distances was performed with reference sequences of 15 Lutjanidae species from the Northeastern Tropical Pacific. Genetic divergences and the NJ tree identified 16 larvae asL. colorado. Morphological investigations of larvae at different developmental stages were performed; similarities and differences are discussed in comparison to four species described previously for the Northeastern Pacific. Pigmentation patterns were the best diagnostic features, particularly the caudal melanophores, at least up to 12.4 mm body length.
A Randomized Controlled Clinical Trial of Prenatal Oral Hygiene Education in Pregnancy‐Associated Gingivitis
Authors: Geurs Nicolaas C. , Jeffcoat Marjorie K. , Tanna Nipul , Geisinger Maria L. , Parry Samuel , Biggio Joseph R. , Doyle Matthew J. , Grender Julie M. , Gerlach Robert W. , Reddy Michael S. 
Published: April 2023

IntroductionResearch shows there is a significant increase in gingival inflammation during pregnancy. This study was conducted to determine if an oral health intervention (OHI), including oral hygiene education delivered by nurse‐led staff and an advanced over‐the‐counter (OTC) oral home care regimen, improved gingival inflammation in pregnant women with moderate‐to‐severe gingivitis compared with a standard oral hygiene control group.MethodsThis was a multicenter, randomized, controlled, single‐masked, parallel group clinical trial conducted in obstetrics clinics of 2 medical centers. A total of 750 pregnant women between 8 and 24 weeks of pregnancy with at least 20 natural teeth and moderate‐to‐severe gingivitis (>30 intraoral bleeding sites) were enrolled. Participants were randomized to either the OHI group, which included oral hygiene instructions supplemented with an educational video and advanced OTC antibacterial/mechanical oral hygiene products, or the control group receiving oral hygiene instructions and standard products. Both groups received oral hygiene instructions from nurse‐led staff. Experienced, masked examiners measured whole mouth gingival index (GI) and periodontal probing depths (PDs) at baseline and months 1, 2, and 3.ResultsParticipants enrolled in this study presented with moderate‐to‐severe gingivitis at baseline. Both the OHI and control groups exhibited significant reductions in GI (P < .001) and PD (P < .03) from baseline that persisted throughout the study period. The OHI group exhibited modest, yet statistically greater, reductions in GI (P ≤ .044) compared with the control at all time points. The reduction in PD directionally favored the OHI group, but between‐group differences were small (<0.03 mm) and not statistically significant (P > .18).DiscussionSignificant gingivitis was prevalent among participants in this study and identifies an opportunity to improve gingival health during pregnancy by providing oral health education during the course of prenatal care when coupled with an advanced OTC oral hygiene regimen.