bluuebunny/crossref_metadata_2025_split huggingface dataset:
Digital Technologies in Supportive Head and Neck Cancer Care: A Promise?
Authors: Verdonck-de Leeuw Irma M. , Leemans C. René , Holtmaat Karen C. J. M. , Jansen Femke 
Published: March 2023

AbstractThis paper addresses the role of digital technologies as part of supportive cancer care, which is of relevance considering the ongoing shortage in healthcare services and the increasing incidence and survival rates in head and neck cancer. Research and development following a participatory design approach helps to deliver patient-centered, effective and efficient applications ready to be used either as adjunctive, guided or fully automated technology. Implementation and upscaling of evidence-based digital technologies in routine cancer care remains a challenge.
DNA Repair Mechanisms as a New Target in Head and Neck Cancer
Authors: Harrington Kevin J. , Hak Charleen M. L. Chan Wah , Rullan Antonio , Patin Emmanuel 
Published: March 2023

AbstractUntil recently, radiotherapy was viewed solely from a tumour cell-autonomous perspective, whereby successful therapy resulted from inflicting breaks in nuclear DNA above an unspecified threshold that exceeded the tumour cell’s capacity for repair. Greater understanding of the importance of non-tumour cell-autonomous, immunological aspects of radiation-induced cell death in the context of the tumour micro-environment (TME) has altered this rather narrow perception. We now know that clinical responses to radiotherapy are inextricably linked to the immune system: loco-regional radiotherapy can trigger abscopal, immune-mediated responses at distant unirradiated sites (albeit rarely), while patients who are pathologically or iatrogenically immunosuppressed may derive less benefit from radiotherapy. The intrinsic biology of individual tumours, their associated microenvironments, and the physical characteristics of the delivered radiation, can all influence the immunogenicity of radiotherapy. By understanding and modulating cross-talk between molecular responses to radiation-induced DNA damage, associated mechanisms of cell death and subsequent innate and adaptive immune responses, we may be able to improve clinical outcomes of radiotherapy.In this chapter, the focus will be on mechanisms of DNA damage repair and how tumours exploit alterations in these to enhance their survival. However, tumour cell-intrinsic aberrations in DNA repair can render tumour cells vulnerable to the effects of radiotherapy and this may be enhanced further by rational use of targeted DNA damage-response inhibitors. In particular, we will focus on how disordered DNA repair and its pharmacological modulation through ataxia telangiectasia and Rad3-related kinase inhibition can lead to radiation-induced immunostimulation and how this can be exploited further in the clinic through the use of specific immunotherapies, such as immune checkpoint blockers. As part of the discussion, specific mechanisms of radiation-induced cell death will be discussed, with emphasis on mechanisms of triggering immunologically visible, pro-inflammatory modes of cell death.
Face Support, Soil Conditioning and Material Transport in Earth-Pressure-Balance and Hydro Shield Machines
Authors: Schößer Britta , Lavasan Arash Alimardani , Baille Wiebke , Barciaga Thomas , Freimann Sascha , Galli Mario , Kube Sebastian , Mianji Peyman , Saberi Poria , Schröer Marius , Thewes Markus , Vogel Andreas , Zhao Chenyang , Zizka Zdenek 
Published: March 2023

AbstractThe excavation process in mechanised tunnelling consists of various technical components whose interaction enables safe tunnel driving. In reference to the existing geological and hydrogeological conditions, different types of face support principles are applied. In case of fine-grained cohesive soils, the face support is provided by Earth Pressure Balanced (EPB) machines, while the Slurry Shield (SLS) technology is adapted in medium-grained to coarse grained non-cohesive soils even under high groundwater pressure. For both machine techniques, the support medium (the excavated and conditioned soil (EPB) or the bentonite suspension (SLS)) needs to be adapted for the specific application. Within this chapter, the theoretical, experimental and numerical developments and results are presented concerning the fundamentals of face support in EPB and SLS tunnelling including the rheology of the support medium, the material transport and mixing process of the excavated soil and the added conditioning agent in the excavation chamber of an EPB shield machine as well as the constitutive models for investigations of the near field interactions between surrounding soil and advancing shield machine.
Real-Time Simulation for Steering the Tunnel Construction Process
Authors: Cao Ba Trung , Heußner Lukas , Jodehl Annika , Obel Markus , Salloum Yara , Freitag Steffen , König Markus , Mark Peter , Meschke Günther , Thewes Markus 
Published: March 2023

AbstractCurrently, in mechanized tunneling, the steering of tunnel boring machines (TBM) in practice is mainly decided based on engineering expert knowledge and recorded monitoring data. In this chapter, a new concept of exploiting the advantages of simulation models to support the steering phase is presented, which allows optimizing the construction process. With the aim to support the steering decision during tunnel construction by means of real-time simulations, predictive simulation models are established in the initial planning phase of a tunnel project. The models are then capable of being continuously updated with monitoring data during the construction. The chapter focuses on explaining models for real-time predictions of logistics processes and tunneling induced settlements as well as the risk of building damage in more details. Additionally, application examples, which are practical-oriented, are also presented to illustrate the applicability of the proposed concept.
Visceral and Tegumentary Leishmaniasis
Authors: Osuolale Olayinka 
Published: March 2023

AbstractVisceral and tegumentary leishmaniasis are neglected tropical diseases caused by the protozoan parasite Leishmania. In this chapter, we discuss the causative organisms and the different clinical manifestations, their global and endemic distribution, and methods of vector and human-to-human transmission. We also explore current drug treatment regimens for both diseases and present a brief introduction to vaccine development.
Vaccines for Canine Leishmaniasis
Authors: Coelho Eduardo A. F. , Christodoulides Myron 
Published: March 2023

AbstractVisceral leishmaniasis is a zoonotic disease in many countries and dogs are considered the main domestic reservoir of Leishmania parasites, and the presence of infected animals represents a potential risk for human disease. In this chapter, we review the state-of-the-art of canine visceral leishmaniasis (CanL) vaccines, discussing the properties and problems associated with the few currently licensed and discontinued vaccines and looking forward to the development of new, more effective vaccines. Reducing the incidence of CanL through vaccination will improve canine health and welfare and contribute to preventing human VL.
Birth Registration, Legal Identity and Impacts on Migration in ASEAN
Authors: Petcharamesree Sriprapha 
Published: March 2023

AbstractBirth registration and legal identity are rights enshrined by international human rights treaties. It is widely recognised that legal identity, through birth registration and issuing documentation, is one of the most important steps to establish access to other fundamental rights, and therefore facilitates the inclusion and well-being of all people in the country. Although all member states of ASEAN recognise such a right, still millions remain unregistered. This chapter will assess why States in the region, which are supposed to be inclusive, still exclude some specific groups from obtaining legal identity, therefore sentencing them to ‘civil death’. This legal invisibility exacerbates ‘irregular migration’ in that it deprives people without legal status and legal identity from access to other rights essential for a minimum acceptable standard of living. Due to this denial of basic human rights, many decide to take the uncertain journey of migration.
Zur empirischen Rekonstruktion leiblicher Praxis
Authors: Antony Alexander 
Published: March 2023

ZusammenfassungDas Kapitel begründet und diskutiert das forschungspraktische Vorgehen der empirischen Studie. Neben der Frage danach, durch welche zentralen forschungspraktischen Operationen sich ein ethnographisches Vorgehen auszeichnet (3.1) und wie sich „Theorie“ und „Empirie“ zueinander verhalten (3.2), sind es insbesondere die Herausforderungen, die sich hinsichtlich einer empirischen Rekonstruktion der Aneignung und Transformation leiblicher Verhaltensschemata ergeben, die im Mittelpunkt stehen. Dies mündet in den Vorschlag, eine ethnographische Binnenperspektive, in Form einer aktiven Teilnahme am Geschehen (3.3), mit einer technisch unterstützten Draufsicht, in Form von synchronen Audio- und Videoaufnahmen, zu kombinieren (3.4.1). Zudem wird die hier verfolgte Verbindung von Diskurs- und Praxisanalyse näher beschrieben (3.4.1). Schließlich werden die Datengrundlage und das methodische Vorgehen erläutert (3.5).
Diskursive Wissensordnungen der sozialen Welt der Atemarbeit
Authors: Antony Alexander 
Published: March 2023

ZusammenfassungDieses erste empirische Kapitel behandelt die diskursive Wissensarbeit der Atemarbeit-Anbieter*innen, die einen zentralen Bestandteil der sozialen Welt der Atemarbeit darstellt. Als wesentlich für einen solchen Fokus erweist sich die Annahme, dass sozialweltspezifische Praktiken nicht bloß ausgeführt werden, sondern dass auch über sie kommuniziert wird. Nach einer Erläuterung des Konzepts der sozialen Welten und einer kurzen Beschreibung des Prozesses der Feldkonstitution erfolgt in einem ersten Schritt eine empirisch-rekonstruktive Charakterisierung der Atemarbeit (4.1). Im Anschluss wird danach gefragt, wie der Verein atman als zentraler ‚Akteur‘ der sozialen Welt der Atemarbeit diskursiv konstruiert wird (4.2). Die Zielsetzung besteht darin, ein Verständnis davon zu gewinnen, wie eine zentrale – sich als autoritativ inszenierende – Instanz der sozialen Welt der Atemarbeit ihr Tun definiert und dieses – und sich selbst – zu legitimieren versucht. Danach wird nach der Beschaffenheit der Wissensdomäne der Atemarbeit gefragt: Welchen Logiken folgt die diskursive Konstruktion atemarbeitsspezifischer Wissensobjekte (4.3)? Wie zu zeigen sein wird, wird das Atmen der Atemarbeit nicht lediglich als biochemischer Stoffwechselvorgang, sondern als eine zu kultivierende Technik des Körpers begriffen. Schließlich wird, basierend auf einer Analyse von Websites von Atemarbeit-Anbieter*innen, gezeigt, wie Klient*innen angesprochen und interessiert gemacht werden (sollen) (4.4).
(Inter-)Agieren an den Rändern des Kommunikativen: Die Interaktionsordnung der Atemarbeit
Authors: Antony Alexander 
Published: March 2023

ZusammenfassungDas Kapitel rekonstruiert in einem ersten Schritt – das Thema des vorangehenden Kapitels fortführend und vertiefend –, wie den Klient*innen die praktischen und normativen Anforderungen der Atemarbeit zunächst sprachlich vermittelt werden (6.1). Deutlich wird hierbei: Die Atemarbeit zielt auf eine auf Dauer gestellte und nach ‚innen‘ gerichtete Form des Wahrnehmens. Der nächste Abschnitt (6.2) beschäftigt sich mit den Besonderheiten atemarbeitsspezifischer Interaktion. Hierbei sind drei Charakteristika bzw. Einschränkungen auszumachen: Die Atemarbeit verfährt erstens in kommunikativer Hinsicht primär unidirektional. Das heißt, die Atemlehrer*innen geben Anweisungen, die Klient*innen versuchen, diese umzusetzen. Die Atemarbeit stellt zweitens eine vergleichsweise schweigsame und bewegungsarme Praktik dar. Schließlich besteht drittens – und dies erweist sich für ein Verständnis der Atemarbeit als wesentlich – die zentrale klient*innenseitige Herausforderung vor allem darin, die sprachlichen Instruktionen in deren leibliche Praxis zu übersetzen. Der letzte Abschnitt (6.3) widmet sich ausführlich diesen Schnittstellen zwischen Sprache und Leiblichkeit. Er geht der Frage nach, wie diese beschaffen sein können und welche praktischen Implikationen sich daraus für das Tun der Klient*innen ergeben.
Vocabulary Changes in the Arab, Turk, and Persian Bilingual Societies in Northeastern Iran
Authors: Mostafavi Pooneh , Akhlaghi Faryar , Asadpour Hiwa 
Published: March 2023

AbstractThis study investigates borrowability of basic vocabularies such as kinship terms, body parts, and natural and weather terms in nine bilingual villages in Northeastern Iran. The surveyed villages serve as a rich bilingual area for linguistic and societal change. Speakers in these villages speak at least one or more languages including Turkish, Turkmen (Turkic), Balochi (Indo-Iranian), and Arabic (Semitic). These languages are widely spoken in the Gulf area in countries such as Iraq, Kuwait, Bahrain, Qatar, Afghanistan, and other neighboring regions. Therefore, it can be a benchmark for further similar studies. The corpus is extracted from the database of Iran Language Atlas (ILA) which include questionnaire data and interviews in different genders, ages, and educational backgrounds. The results show deep basic lexical changes in the speech communities.
Innovation, Technology Transfer, and Endogenous Growth in the GCC Countries
Authors: Akkas Erhan , Altiparmak Suleyman Orhun 
Published: March 2023

AbstractThis chapter investigates the economic changes of the GCC countries within the framework of the nature of economic diversification by analyzing innovation performance indices, economic freedom indices, and doing business indicators. This paper shows that the GCC states’ economic strategies are still limited in their ability to affect economic performance so that their economies are still heavily dependent on natural resources. Thus, this study stresses the need for GCC countries to develop technology- and innovation-based private sectors aside from hydrocarbons in accordance with the endogenous growth theory. This research recommends that each GCC state should support investments in the private sector, which can contribute to the development of innovation and technology.
Yemen, the Wound that Still Bleeds in the Gulf and Beyond
Authors: Foyth Joel 
Published: March 2023

AbstractThis chapter addresses the causes and reasons for continuation of Yemeni civil war. In 2011, Yemenis mobilized to demand the departure of President Abdullah Saleh and the establishment of a better society. After thirty years in power, Saleh signed his resignation and began a political transition that was initially promising. This chapter argues that the absence of real change and the complexity of Yemeni society undermined the process, leading to civil conflict. In addition, the turbulent Yemeni reality was intertwined with dark regional geopolitics, marked by sectarianism and competition between Saudi Arabia, Iran, and United Arab Emirates. This chapter suggests that the war eventually turned into a brutal fight, which has been qualified as The century’s worst humanitarian crisis.
Social Justice Under COVID-19: A Comparative Study of Health and Socioeconomic Policy Responses in the Arab Mashreq and the Arab Gulf
Authors: Aref Ahmed 
Published: March 2023

AbstractThis chapter provides a critical overview on the patterns of health and socioeconomic policy responses in the Arab Mashreq and the GCC countries, from a social justice perspective. The social stratification and inheriting inequality in the Arab Mashreq affected the policy response, by favoring the economic support to big businesses, and depriving the poor from accessing quality health care, which shaped a class-based recovery. However, this disparity in the GCC policy responses in the health sector did not exist, since high-quality health care was provided to all. Moreover, the economic support was comprehensive and did not exclude small and medium-sized enterprises. However, the labor policy response undermined the social justice in the GCC pandemic response. Austerity measures were significantly directed toward the expatriate workers by reducing their numbers or cutting salaries and benefits. The chapter provides contextual analysis to draw a full picture of the structural factors that represent pressing determinants shaping different typologies of policy response in both regions.
ASEAN and the Death Penalty: Theoretical and Legal Views and a Pathway to Abolition
Authors: Petcharamesree Sriprapha , Boonlong Raine , Breen Danthong 
Published: March 2023

AbstractThis concluding chapter reviews how retentionist countries often seek to justify their use of capital punishment by relying on punishment theories that draw a distinction between the infliction of just punishment and arbitrary and unjust violence by the State. It also examines how the continuing use of capital punishment in Southeast Asian countries has been explained by some experts to reflect the distinctive Asian perception of human rights, being one that oversees the prevalence of community rights over individual rights, thus reinforcing the desideratum of the State to accentuate stringent punishment for offenders who are viewed as rebelling against the regiments of State control.There has been an undeniable worldwide decline in retention over the last forty years. This chapter, therefore, asks why, despite this inexorable global trend and the universal recognition of human rights, do most ASEAN States cling to retentionist principles and policies? Moving beyond traditional theories on criminal justice, particularly retribution and utilitarianism, this chapter attempts to conceptually unpack the factors used to justify the retention of the death penalty in the region. It concludes that the death penalty situation in the eight ASEAN countries remains rather static and the record somehow reveals a very mixed reality, reflecting the absence of any shared policy on the death penalty among AMS other than the proviso, ‘in accordance with law’. Some observations and recommendations are then made for Member States to consider possible steps towards the abolition of the death penalty.
Traversing Learning and Leading Collaboration: Stepping Towards New Power Values During Turbulent and In-Between Times
Authors: Smith Catherine , Selkrig Mark , Dulfer Nicky , Harrison Matthew , Cochrane Thomas , McKernan Amy , Pollard Vikki , Rasche Jeni 
Published: March 2023

AbstractIn this chapter, we consider how perspectives about leadership, debates related to higher education, health promotion principles, and frameworks of new and old power informed our work as a group of disparate academic and professional staff who were identified to establish a’Digital Taskforce’ (DT) during the global pandemic. The role of the DT was to support teaching staff in Melbourne Graduate School of Education as it moved rapidly to remote and online teaching. By exploring aspects of our work together within the ecologies of policy, systems, groups, and individuals, we identify key elements of responding and bringing about change as a group of leaders during that turbulent time. Through our collaborative narrative, we also ponder how facets of our work may inform emergent ideas about the scholarship of teaching and learning and the possibilities for rethinking higher education.
Reaching for Reconciliation in Digital Spaces
Authors: Toscano Maurizio , Galatis Aristidis , Smith Catherine 
Published: March 2023

AbstractThis multi-voiced and polyphonic chapter discusses the usefulness of discomfort in contestation in digital pedagogies when working for reconciliation in colonised geographies. To do so, we outline the complexities of teaching in digital spaces during the pandemic, and the imperative to honour the first peoples and custodians of the country from which we are teaching. We consider the global and local considerations of movements like #blacklivesmatter, and how the affordances of pedagogies like Communities of Inquiry provide possibilities for embracing the discomforts of whiteness in virtual spaces and providing opportunities for authentic connection in digital teaching and learning.
Molecular Crystal Calculation Prospects for Structural Phase Transitions
Authors: Nakayama Naofumi , Goto Hitoshi 
Published: March 2023

AbstractTo establish the theory of soft crystals, computational chemistry must be applied to analyze the structural phase transitions of molecular crystals and develop new methodologies. The accuracy of first-principles calculations for molecular crystals has rapidly improved over the last decade with the contribution of the Cambridge Crystallographic Data Centre blind test, which predicts the crystal structure from the structural formula. However, it is often difficult to apply first-principles calculations to large molecular crystals, such as typical soft crystals, because of the computational cost. In this chapter, we review the applicability of crystal force field calculations as an alternative method for theoretically analyzing molecular crystals. We also introduce some examples of our previous collaborations and discuss the promising methodologies to elucidate the soft crystal phenomena.
Vapochromic Soft Crystals Constructed with Metal Complexes
Authors: Kato Masako 
Published: March 2023

AbstractVapochromism, a phenomenon in which the color or luminescence color of a substance changes in response to gaseous molecules, has potential for developing sensor materials to detect harmful substances in the environment. In addition, vapochromism is scientifically interesting for the direct visualization of interactions between gases and solids. The crystals of metal complexes involve diverse and flexible electronic interactions, such as metal–metal and metal–ligand interactions. It is expected that slight structural changes in such crystals will lead to distinct color or emission color changes, thus achieving highly sensitive and selective vapochromic responses. Consequently, highly ordered and flexible response systems (i.e., soft crystals) can be constructed. This chapter introduces the interesting and attractive features of vapor-responsive soft crystals by discussing platinum complexes that show color and luminescence changes in dilute vapor atmospheres while maintaining an ordered structure, nickel(II) complexes that change magnetic properties in conjunction with a color change, and copper(I) complexes that change luminescence color in response to N-heteroaromatic vapors.
Droplet-mediated long-range interfacial correlations. Exact field theory for entropic repulsion effects
Authors: Squarcini Alessio , Tinti Antonio 
Published: March 2023

Abstract
We consider near-critical two-dimensional statistical systems at phase coexistence on the half plane with boundary conditions leading to the formation of a droplet separating coexisting phases. General low-energy properties of two-dimensional field theories are used in order to find exact analytic results for one- and two-point correlation functions of both the energy density and order parameter fields. The subleading finite-size corrections are also computed and interpreted within an exact probabilistic picture in which interfacial fluctuations are characterized by the probability density of a Brownian excursion. The explicit analysis of the closed-form expression for order parameter correlations reveals the long-ranged character of interfacial correlations and their confinement within the interfacial region. The analysis of correlations is then carried out in momentum space through the notion of interface structure factor, which we extend to the case of systems bounded by a flat wall. The presence of the wall and its associated entropic repulsion leads to a specific term in the interface structure factor which we identify.