bluuebunny/crossref_metadata_2025_split huggingface dataset:
Groundwater characterization of the eastern Minesing Wetlands in support of the endangered Hine’s emerald dragonfly (Somatochlora hineana)
Authors: Spoelstra John , Post Ryan 
Published: March 2023

AbstractThe Minesing Wetlands contain Canada’s only known population of Hine’s emerald dragonfly (HED), a species listed as endangered since 2011. The HED relies on groundwater discharge areas to complete its life cycle and therefore the population is potentially sensitive to changes in groundwater. The goals of this study were to, (1) characterize groundwater discharge to the eastern portion of the Minesing Wetlands, which corresponds to the HED habitat, (2) document any significant changes in groundwater chemistry since a 1998 study, and (3) establish a comprehensive baseline water quality data set to facilitate future comparisons. Consistent with HED habitats in the USA, the chemistry of Minesing Wetlands groundwater was dominated by calcium and bicarbonate. Low groundwater chloride and nitrate concentrations indicated minimal impact from activities such as road salt application and fertilizer use. Nitrate was generally only found at the wetland margin where groundwater springs emerged from the base of the uplands. The dominant form of inorganic nitrogen in wetland groundwater was ammonium (max = 1.5 mg N/L), and soluble reactive phosphorus concentrations were also relatively high (8 to 122 µg/L). The most consistent change in wetland groundwater chemistry between the 1998 study and samples collected in 2015–2017 was that chloride concentrations in 10 of 23 wells increased over time, however the maximum mean well chloride (11.6 mg/L) remained well below the guideline for the protection of aquatic life (120 mg/L). To preserve HED habitat, potential impacts to groundwater need to be considered during land use planning for the recharge area.
Dual-Band Millimeter Wave 2 × 2 MIMO Slot Antenna with Low Mutual Coupling for 5G Networks
Authors: Ali Wael A. E. , Ibrahim Ahmed A. , Ahmed Ashraf E. 
Published: March 2023

AbstractA dual-band 28/38 GHz multiple-input multiple-output (MIMO) two elements antenna for the next 5G network is proposed in this paper. The single element is composed of a slot monopole antenna loaded with stub and a small crescent with an entire size of 15 × 15 mm2. The two elements are added to compose the suggested configuration. One of the antennas is printed on the upper layer while the other is located on it's back of the substrate to improve the coupling between elements without using any decoupling structures. The innovative antenna of dual-band works at 28/38 GHz and is achieved by adjusting the stub length and the crescent radius. The introduced MIMO antenna system has been experimented and the results have the same compatible trace with the simulated outcomes. The proposed two ports MIMO achieved a reasonable gain that reaches 5.7 and 6.9 dBi in the 28/38 GHz bands, respectively. The proposed MIMO antenna performance is also analyzed and achieved the envelope correlation coefficient, a diversity gain, and channel capacity Loss of about 10–4, 10 dB, and less than 0.3 bit/s/Hz, respectively over the 28/38 GHz bands. Finally, from the simulated and measured outcomes, it can be confirmed that the suggested MIMO antenna system can be applied to 5G wireless telecommunication applications.
Embryonic Development of Pediculus humanus capitis: Morphological Update and Proposal of New External Markers for the Differentiation Between Early, Medium, and Late Eggs
Authors: Álvarez-Fernández Blanca E. , Valero M. Adela , Nogueda-Torres Benjamín , Morales-Suárez-Varela M. María 
Published: March 2023

Abstract
Background and Objectives
The head louse Pediculus humanus capitis is a cosmopolitan ectoparasite that causes pediculosis. In the study of human lice, little research focuses on embryonic development. Currently, external markers of embryonic development represent a new approach in the evaluation of ovicidal drugs. The objective of this work was to update the morphology of embryonic development and propose novel external markers to differentiate between early, medium, or late P. h. capitis eggs.

Methods
Using stereoscopic light microscopy, we describe the morphological characteristics of P. h. capitis eggs with a special focus on embryonic development.

Results
The morphological analysis of the eggs revealed the presence of an operculum with ten aeropyles, although no micropyles were observed. For the first time, the presence of defective eggs that were non-viable due to the apparent absence of yolk granules was documented. The early eggs presented yolk granules and developing germ bands, while the medium eggs presented an embryonic rudiment and the outlines of the eyes and limbs. In late eggs, the head with eyes and antennae, the thorax with three pairs of legs, and the abdomen with six pairs of spiracles were observed as formed structures. At the end of this stage, the embryos acquired the morphology of the nymph I stage.

Conclusion
We propose novel biomarkers (e.g., the presence of spiracles and antennae, the proportion of the egg occupied by the embryo) to facilitate the differentiation between the developmental stages. The updated morphological characteristics of P. h. capitis eggs facilitate the standardization of toxicological tests in the quest for ovicidal drugs.
Daily combined measurement of platelet count and presepsin concentration can predict in-hospital death of patients with severe coronavirus disease 2019 (COVID-19)
Authors: Ishikura Hiroyasu , Maruyama Junichi , Nakashio Maiko , Hoshino Kota , Morimoto Shinichi , Izutani Yoshito , Noake Junta , Yamagaito Takahiro , Yoshida Maho , Kitamura Taisuke , Nakamura Yoshihiko 
Published: March 2023

AbstractThe purpose of this study was to classify patients with severe COVID-19 into more detailed risk groups using coagulation/fibrinolysis, inflammation/immune response, and alveolar/myocardial damage biomarkers, as well as to identify prognostic markers for these patients. These biomarkers were measured every day for eight intensive care unit days in 54 adult patients with severe COVID-19. The patients were classified into survivor (n = 40) and non-survivor (n = 14) groups. Univariate and multivariate analyses showed that the combined measurement of platelet count and presepsin concentrations may be the most valuable for predicting in-hospital death, and receiver operating characteristic curve analysis further confirmed this result (area under the curve = 0.832). Patients were consequently classified into three groups (high-, medium-, and low-risk) on the basis of their cutoff values (platelet count 53 × 103/µL, presepsin 714 pg/mL). The Kaplan–Meier curve for 90-day survival by each group showed that the 90-day mortality rate significantly increased as risk level increased (P < 0.01 by the log-rank test). Daily combined measurement of platelet count and presepsin concentration may be useful for predicting in-hospital death and classifying patients with severe COVID-19 into more detailed risk groups.
Leading teams while exhausted: Perspectives from healthcare epidemiology and beyond
Authors: Mullin Rebecca A. , Hota Susy S. , Bearman Gonzalo 
Published: March 2023

Abstract
Mental fatigue and burnout are concerns for healthcare organizations, but their effects on leaders have not been thoroughly studied. Infectious diseases teams and leaders are at risk for mental fatigue and burnout due to the increased demands from the coronavirus disease 2019 (COVID-19) pandemic, additive effects of severe acute respiratory coronavirus virus 2 (SARS-CoV-2) (omicron) and δ (delta) variant surges, and unique pre-existing pressures. No single intervention can reduce stress and burnout in healthcare workers. Work-hour limitations may have the biggest impact in physician burnout mitigation. Institutional and individual programs focused on mindfulness may improve well-being in the workplace. Leading during times of stress requires a multimodal approach and an understanding of goals and priorities. Greater awareness of burnout and fatigue across the healthcare spectrum and continued research are required to advance healthcare worker well-being.
Intersectoral and multisectoral approaches to enable recovery for people with severe mental illness in low- and middle-income countries: A scoping review
Authors: J. van Rensburg André , Brooke-Sumner Carrie 
Published: March 2023

Abstract
The needs of people with severe mental illness are complex and require a range of services embedded in well-coordinated systems of care to enable recovery, promote well-being and optimise social integration. The concept of recovery is strongly rooted in the centrality of multi and intersectoral systems of care, and, while multi and -intersectoral dimensions of mental health systems have been highlighted in analyses focusing on high-income regions, little has been elaborated in terms of these approaches in the recovery of people with severe mental illness (SMI) in low- and middle-income countries (LMICs). The aim of this review was to identify and describe multi and intersectoral approaches underpinning community-based SMI recovery interventions in LMICs. A scoping review was carried out following the following steps: (1) Objectives for the review were developed and refined; (2) A systematic search of databases (EbscoHost, PubMed, Google Scholar) and previous reviews were undertaken from 2012 to 2022, where relevant papers were identified; (3) Papers with a focus on SMI and recovery, a specific description of an intervention, located in LMICs, with explicit linkages between sectors, and published in English, were selected for inclusion; (4) Data were extracted and charted and (5) Findings were analysed and reported thematically. Thirty-six papers were included for analysis, from 18 countries, including qualitative studies, trials, desktop and secondary data reviews and case studies. Examples of multi- and intersectoral action included collaboration between healthcare and community support systems, collaboration in providing supported housing and supportive community spaces for recovery, and linkages between biomedical and social spheres of care. Barriers included the dominance of mental health professions in delivering care, community-based stigmatising attitudes towards SMI. Multi- and intersectoral collaboration for SMI recovery requires investments in financing, education and coordination by a governing body.
Evaluation of tumour necrosis factor alpha-stimulated gene-6 and fibroblast growth factor-2 levels in patients diagnosed with multi-system inflammatory syndrome in children
Authors: Tasci Onur , Dogan Kubra 
Published: March 2023

AbstractInvestigations are still ongoing about the pathophysiology of multi-system inflammatory syndrome in children, which can progress with serious morbidity and mortality after COVID-19 infection. In this study, we aimed to investigate whether fibroblast growth factor-2 and tumour necrosis factor alpha-stimulated gene-6 levels play a role in the diagnosis of the disease and on cardiac involvement. Twenty-three patients (11 girls, 12 boys) and 26 healthy controls (10 girls, 16 boys) were included in the study. The mean age of the patient and control group was 8.45 ± 2.43 and 10.73 ± 4.27 years, respectively. There was no difference between the fibroblast growth factor-2 and tumour necrosis factor alpha-stimulated gene-6 levels of the patient and control groups. When the patients with myocardial involvement in the patient group were compared with the patients without myocardial involvement in terms of fibroblast growth factor-2 and tumour necrosis factor alpha-stimulated gene-6 levels, no difference was found between these groups. The correlation of fibroblast growth factor-2 and tumour necrosis factor alpha-stimulated gene-6 levels with other laboratory parameters was investigated in the patient group. Fibroblast growth factor-2 was moderately inversely correlated with white blood cell count (r = -0.541, p = 0.008), absolute neutrophil count (r = −0.502, p = 0.015) and C-reactive protein (r = −0.528, p = 0.010). Fibroblast growth factor-2 was strongly inversely correlated with erythrocyte sedimentation rate (r = −0.694, p =<0.001). Our data show that fibroblast growth factor-2 and tumour necrosis factor alpha stimulated gene-6 do not provide sufficient information about diagnosis and cardiac involvement in multi-system inflammatory syndrome in children.
Paleocene‐Eocene High‐Pressure Carbonation of Western Alps Serpentinites: Positive Feedback Between Deformation and CO2‐CH4 Fluid Ingression Responsible for Slab Slicing?
Authors: Herviou Clément , Bonnet Guillaume 
Published: March 2023

AbstractMeter‐ to hectometer‐size horizons of carbonate‐bearing talcschists are found along or near the contacts between the different Liguro‐Piemont subduction slices. Through mineral and bulk‐rock geochemistry, fluid inclusion analyses, and titanite U‐Pb geochronology, this study shows that these horizons formed by the transformation of serpentinites, at conditions close to peak burial, due to fluid infiltration sourced from surrounding sediments. These rocks containing large amounts of carbonates and high concentrations of fluid‐mobile elements may be significant for carbon cycling and contribute to the composition of arc magmas once the main constitutive assemblage destabilizes at high‐pressure and high‐temperature conditions. Following fluid infiltration, the formation of talc likely controlled strain localization in these horizons, enhancing in turn the ingression of external fluids and creating a positive feedback loop between deformation and fluid infiltration. We suggest that these rocks may have acted as major rheological weaknesses responsible for material offscraping from the downgoing plate.
Glacier Surface Heatwaves Over the Tibetan Plateau
Authors: Chen Wenfeng , Yao Tandong , Zhang Guoqing , Woolway R. Iestyn , Yang Wei , Xu Fenglin , Zhou Tao 
Published: March 2023

AbstractThe Tibetan Plateau (TP) has warmed at a rate twice the global average and presents unique warming patterns in surface temperature changes. However, key characteristics of glacier surface heatwave duration and intensity over the TP during the present extreme warming period are still unknown. In this study, we show that surface temperatures in glacial regions of the TP (0.37 ± 0.10°C per decade) have increased faster than those in non‐glacial areas (0.29 ± 0.05°C per decade) between 2001 and 2020. Moreover, the duration (5.3 ± 3.2 days per decade) and cumulative intensity (24.9 ± 16.3 days °C per decade) of glacier surface heatwaves have increased significantly during autumn. Our results demonstrate an elevation dependence to these key warming characteristics, which we also suggest are associated with extreme glacier mass loss. Here, we highlight potential threats to the sustainability of glacier water resources and increasing risk of glacier related hazards at the “roof of the world.”
Constraining the Varied Response of Northern Hemisphere Winter Circulation Waviness to Climate Change
Authors: Nie Yu , Chen Gang , Lu Jian , Zhou Wenyu , Zhang Yang 
Published: March 2023

AbstractWhile a large latitudinal displacement of the westerly jet brings about disproportionate socioeconomic impacts over Northern Hemisphere midlatitude continents, it is not well understood as to whether the winter circulation will become wavier or less in response to climate change. Here, using observations and large ensembles of climate models, we show that changes in atmospheric waviness can be estimated from the optimal structures of the westerly jet for wavier circulation, which are obtained from an advection‐diffusion model. Thus, the changes in westerly jet structure in climate models under climate change provide a physical constraint on changes in atmospheric waviness, indicating that the North Atlantic wave activity will experience a robust decline in a warmer climate, while future North Pacific wave activity is obscured by model uncertainty rather than internal variability. These findings highlight the changes to jet stream structure as a constraint for regional circulation waviness in a changing climate.
Seasonal West‐East Seesaw of M2 Internal Tides From the Luzon Strait
Authors: Zhao Zhongxiang , Qiu Bo 
Published: March 2023

AbstractSatellite altimetry sea surface height (SSH) measurements from 1993 to 2017 are used to investigate the seasonal variability of mode‐1 M2 internal tides from the Luzon Strait. The 25 years of SSH data are divided into four seasonal subsets, from which four seasonal internal tide models are constructed following the same mapping procedure. Climatological seasonal hydrography in the World Ocean Atlas 2013 is used to calculate two seasonally variable parameters required in the mapping procedure: Wavelength and the transfer function from the SSH amplitude to depth‐integrated energy flux. The M2 internal tides from the Luzon Strait are extracted using propagation direction determined in plane wave analysis. The satellite results show that the westward and eastward M2 internal tides both demonstrate significant seasonal variation. The westward and eastward internal tides seesaw seasonally: The westward internal tides strengthen (weaken) in summer and fall (winter and spring); while the eastward internal tides strengthen (weaken) in winter and spring (summer and fall). We suggest that the seasonal seesaw is mainly determined by ocean stratification and the Kuroshio Current; however, further studies are needed to quantify their relative contributions.
Capturing High‐Resolution Air Pollution Features Using the Multi‐Scale Infrastructure for Chemistry and Aerosols Version 0 (MUSICAv0) Global Modeling System
Authors: Tang Wenfu , Pfister Gabriele G. , Kumar Rajesh , Barth Mary , Edwards David P. , Emmons Louisa K. , Tilmes Simone 
Published: March 2023

AbstractThe Multi‐Scale Infrastructure for Chemistry and Aerosols (MUSICA) enables the study of atmospheric chemistry and aerosols at global to local scales. MUSICA version 0 (MUSICAv0) is a configuration of the Community Earth System Model (CESM) with regional refinement (RR). We compared the regional scale spatial and temporal variabilities of air pollutants simulated by this newly developed multiscale model and a widely used regional model—WRF‐Chem (the Weather Research and Forecasting model coupled with Chemistry). The O3 and PM2.5 mean biases of the two WRF‐Chem simulations over the U.S. are 5–9 ppb and −3 μg/m3 during August and September 2020. The MUSICAv0 simulation has larger O3 mean bias (11 ppb) but smaller PM2.5 mean bias (−1 μg/m3) compared to the two WRF‐Chem simulations. As indicated by spatial and temporal statistical measures, the variability in meteorological parameters (temperature, precipitation), and ozone and PM2.5 are similar across a range of temporal and spatial scales in MUSICAv0 and WRF‐Chem. We demonstrate the new capability of the global MUSICAv0 at regional scale through two examples—(a) plumes from western U.S. fires that passed through the domain boundary of WRF‐Chem and were transported back into the domain and impacted air quality on the eastern U.S.; and (b) impact of stratospheric intrusion on the troposphere.
CAFrgDB: a database for cancer-associated fibroblasts related genes and their functions in cancer
Authors: Yuan Qiang , Chu Yi , Li Xiaoyu , Shi Yunshu , Chen Yingying , Zhao Jimin , Lu Jing , Liu Kangdong , Guo Yaping 
Published: March 2023

AbstractAs one of the most essential components of the tumor microenvironment (TME), cancer-associated fibroblasts (CAFs) interact extensively with cancer cells and other stromal cells to remodel TME and participate in the pathogenesis of cancer, which earmarked themselves as new promising targets for cancer therapy. Numerous studies have highlighted the heterogeneity and versatility of CAFs in most cancer types. Thus, the identification and appropriate use of CAF-related genes (CAFGenes) in the context of specific cancer types will provide critical insights into disease mechanisms and CAF-related therapeutic targets. In this study, we collected and curated 5421 CAFGenes identified from small- or large-scale experiments, encompassing 4982 responsors that directly or indirectly participate in cancer malignant behaviors managed by CAFs, 1069 secretions that are secreted by CAFs and 281 regulators that contribute in modulating CAFs in human and mouse, which covered 24 cancer types. For these human CAFGenes, we performed gene expression and prognostic marker-based analyses across 24 cancer types using TCGA data. Furthermore, we provided annotations for CAF-associated proteins by integrating the knowledge of protein-protein interaction(s), drug-target relations and basic annotations, from 9 public databases. CAFrgDB (CAF related Gene DataBase) is free for academic research at http://caf.zbiolab.cn and we anticipate CAFrgDB can be a useful resource for further study of CAFs.
Rab32 promotes glioblastoma migration and invasion via regulation of ERK/Drp1-mediated mitochondrial fission
Authors: Chen Pin , Lu Yanbing , He Binfeng , Xie Tao , Yan Chaolong , Liu Tengfei , Wu Silin , Yeh Yuyang , Li Zeyang , Huang Wei , Zhang Xiaobiao 
Published: March 2023

AbstractThe highly widespread and infiltrative nature of glioblastoma multiforme (GBM) makes complete surgical resection hard, causing high recurrence rate and poor patients’ prognosis. However, the mechanism underlying GBM migration and invasion is still unclear. In this study, we investigated the role of a Ras-related protein Rab32 on GBM and uncovered its underlying molecular and subcellular mechanisms that contributed to GBM aggressiveness. The correlation of Rab32 expression with patient prognosis and tumor grade was investigated by public dataset analysis and clinical specimen validation. The effect of Rab32 on migration and invasion of GBM had been evaluated using wound healing assay, cell invasion assay, as well as protein analysis upon Rab32 manipulations. Mitochondrial dynamics of cells upon Rab32 alterations were detected by immunofluorescence staining and western blotting. Both the subcutaneous and intracranial xenograft tumor model were utilized to evaluate the effect of Rab32 on GBM in vivo. The expression level of Rab32 is significantly elevated in the GBM, especially in the most malignant mesenchymal subtype, and is positively correlated with tumor pathological grade and poor prognosis. Knockdown of Rab32 attenuated the capability of GBM’s migration and invasion. It also suppressed the expression levels of invasion-related proteins (MMP2 and MMP9) as well as mesenchymal transition markers (N-cadherin, vimentin). Interestingly, Rab32 transported Drp1 to mitochondrial from the cytoplasm and modulated mitochondrial fission in an ERK1/2 signaling-dependent manner. Furthermore, silencing of Rab32 in vivo suppressed tumor malignancy via ERK/Drp1 axis. Rab32 regulates ERK1/2/Drp1-dependent mitochondrial fission and causes mesenchymal transition, promoting migration and invasion of GBM. It serves as a novel therapeutic target for GBM, especially for the most malignant mesenchymal subtype.