bluuebunny/crossref_metadata_2025_split huggingface dataset:
Employee's performance and Kaizen events' success: does supervisor behaviour play a moderating role?
Authors: Kharub Manjeet , Gupta Himanshu , Rana Sudhir , McDermott Olivia 
Published: January 2023

PurposeThe study's goal was to identify the factors contributing to the practical completion of Kaizen events (KEs). The effect of the work-study man's characteristics, the supervisor's conduct and the autonomy of the Kaizen team are analysed in this study.Design/methodology/approachData were collected from 249 respondents working in the manufacturing sector in India, mainly those who had been involved in Kaizen projects. Three-step procedures, namely, exploratory factor analysis, confirmatory factor analysis and partial least squares, have been applied to test the research hypotheses through structural equational modelling.FindingsThe exploratory factor analysis extracted in-role performance, creative performance and human aspect as latent variables explaining work-study man's performance (eigenvalue = 1). The study's findings indicate that the performance of work-study man (in-role, creative and human) and supervisors' conduct is directly related to the success of KEs. It was shown that supervisors might influence the outcomes of KEs only by moderating the human aspects. Additionally, the degree of autonomy of the Kaizen team was found having a significant positive relationship with the success of KEs.Practical implicationsThe current study suggests that in-role and creative performance are prime assets of a work-study man. At the same time, the human aspect is a delicate issue that can affect the supervisor's behaviour. Therefore, the study implies that work-study men have the tactics and abilities to work with other co-workers to make a Kaizen project successful.Originality/valueAlthough the significance of Kaizen projects has been widely emphasised, past research has failed to establish what factors contribute to the success of Kaizen efforts. Similarly, the supervisor's critical role has been highlighted several times. However, it is unclear how their conduct influences the relationship between work-study man's performance and the effectiveness of Kaizen projects. This study contributes significantly to organisational culture and human resource management by answering these questions.
Beveridge at Eighty: Learning the Right Lessons
Authors: Kelly Gavin , Pearce Nick 
Published: January 2023

AbstractThe eightieth anniversary of the Beveridge inquiry is a timely moment to consider how the landmark report is used within contemporary UK politics. Calls for a ‘new Beveridge’ reflect a desire for a rupture with the past and the creation of a radical new welfare consensus. But this reflects a misunderstanding: Beveridge's approach was organic in nature, building on decades of experimentation, politically contested rather than consensual, and intellectually pluralist rather than moored to a single ideological worldview. The real insight Beveridge offers us today flows not from his substantive agenda—which was rooted in a particular set of historic circumstances—but as an approach to securing social reform. Successful welfare advances over the last generation have drawn on these ‘Beveridgean instincts’. Rather than calling for a new twenty‐first century blueprint to be handed down from above, reformers should build on experimentation and successful incremental change, from within the UK and abroad.
Venous chambers in clinical use for hemodialysis have limited capacity to eliminate microbubbles from entering the return bloodline: An in vitro study
Authors: Jonsson Per , Stegmayr Christofer , Stegmayr Bernd , Forsberg Ulf 
Published: January 2023

AbstractBackgroundDuring hemodialysis (HD), blood passes through an extracorporeal circuit (ECC). To prevent air administration to the patient, a venous chamber (chamber) is located before the blood return. Microbubbles (MBs) may pass through the chamber and end up as microemboli in organs such as the brain and heart.This in vitro study investigated the efficacy of various chambers in MB removal.Materials and MethodsThe in vitro recirculated setting of an ECC included an FX10 dialyzer, a dextran‐albumin solution to mimic blood viscosity and chambers with different flow characteristics in clinical use (Baxter: AK98 and Artis, Fresenius: 5008 and 6008) and preclinical test (Embody: Emboless®). A Gampt BCC200 device measured the presence and size of MBs (20–500 μm). Percentage change of MBs was calculated: ΔMB% = 100*(outlet–inlet)/inlet for each size of MB. Blood pump speed (Qb) was 200 (Qb200) or 300 (Qb300) ml/minute. Wilcoxon paired test determined differences.ResultsWith Qb200 median ΔMB% reduction was: Emboless −58%, AK98 −24%, Fresenius 5008 −23%, Artis −8%, and Fresenius 6008 ± 0%. With Qb300 ΔMB% was: Emboless −36%, AK98 ± 0%, Fresenius 5008 ± 0%, Artis +25%, and Fresenius 6008 + 21%. The Emboless was superior to all other chambers with Qb200 and Qb300 (p < 0.001). Further, the Emboless with Qb300 still eliminated more MBs than all other chambers with Qb200 (p ≤ 0.003).ConclusionThe results from the present study indicate that flow characteristics of the chamber and the Qb are important factors to limiting exposure of MB to the return bloodline. The Emboless chamber reduced MBs more effective than those chambers in clinical use investigated.
Gastric glomus tumor resection using laparoscopic endoscopic cooperative surgery: A case report
Authors: Iijima Yasuhiro , Tokumaru Shigeo , Kitazawa Masato , Nakamura Satoshi , Koyama Makoto , Yamamoto Yuta , Ehara Takehito , Hondo Nao , Miyazaki Satoru , Soejima Yuji 
Published: January 2023

AbstractGastric glomus tumors are rare submucosal mesenchymal neoplasms that are difficult to diagnose preoperatively. We present a case of a 60‐year‐old woman who was diagnosed with a gastric glomus tumor using endoscopic ultrasonography‐guided fine‐needle aspiration biopsy. The tumor was successfully resected with laparoscopic endoscopic cooperative surgery (LECS). LECS could be an effective method for the resection of gastric glomus tumors.
Median 4‐year outcomes of salvage irreversible electroporation for localized radio‐recurrent prostate cancer
Authors: Geboers Bart , Scheltema Matthijs J. , Blazevski Alexandar , Katelaris Athos , Doan Paul , Ali Imran , Agrawal Shikha , Barreto Daniela , Matthews Jayne , Haynes Anne‐Maree , Delprado Warick , Shnier Ron , Thompson James E. , Stricker Phillip D. 
Published: January 2023

ObjectivesTo evaluate the safety, and short to mid‐term oncological and quality‐of‐life (QoL) outcomes of focal irreversible electroporation (IRE) for radio‐recurrent prostate cancer (PCa) at a median follow‐up of 4 years.Patients and MethodsThis was a single‐centre series of men with biopsy‐proven radio‐recurrent PCa treated with IRE between December 2013 and February 2022, with a minimum follow‐up of 6 months. Follow‐up included magnetic resonance imaging at 6 months, and standard transperineal saturation template biopsies at 12 months. Further biopsies were guided by suspicion on serial imaging or prostate‐specific antigen (PSA) levels. Validated questionnaires were used to measure functional outcomes. Significant local recurrence was defined as any International Society of Urological Pathology (ISUP) score ≥ 2 on biopsies. Progression‐free survival was defined as no signs of local or systemic disease on either imaging or template biopsies, or according to the Phoenix criteria for biochemical recurrence.ResultsFinal analysis was performed on 74 men with radio‐recurrent PCa (median age 69 years, median PSA level 5.4 ng/mL, 76% ISUP score 2/3). The median (range) follow‐up was 48 (27–68) months. One rectal fistula occurred, and eight patients developed urethral sloughing that resolved with transurethral resection. Among patients who returned questionnaires (30/74, 41%), 93% (28/30) had preserved urinary continence and 23% (7/30) had sustained erectile function at 12‐month follow‐up. Local control was achieved in 57 patients (77%), who needed no further treatment. Biopsy diagnosed 41(55%) patients received follow up template biopsies, in‐field recurrences occurred in 7% (3/41), and out‐field recurrences occurred in 15% of patients (6/41). The metastasis‐free survival rate was 91% (67/74), with a median (interquartile range) time to metastases of 8 (5–27) months. The Kaplan–Meier estimated 5‐year progression‐free survival rate was 60%.ConclusionsThese short‐ to mid‐term safety, oncological and QoL outcome data endorse results from smaller series and show the ability of salvage focal IRE to safely achieve oncological control in patients with radio‐recurrent PCa.
Tetrandrine inhibits migration and invasion of BGC‐823 and MKN‐45 cells by regulating PI3K/AKT/mTOR signaling pathway
Authors: Xue Wanli , Sun Rui , Hao Zheng , Xing Zhenzhen , Cheng Hongjie , Shao Lei 
Published: January 2023

AbstractTetrandrine (Tet), a traditional Chinese herbal medicine extract, exhibits anti‐cancer effect on many types of cancer. Nonetheless, the action mechanism of Tet in gastric cancer (GC) is still largely unclear. In the current study, proliferation, invasion, and migration of the BGC‐823 and MKN‐45 cells were effectively suppressed by Tet treatment in a dose‐dependent manner. Moreover, Tet suppressed expression of the proliferation‐associated protein PCNA, the interstitial cell phenotype N‐cadherin, and the extracellular matrix‐associated MMP‐2 and MMP‐9 in BGC‐823 and MKN‐45 cells in a dose‐dependent manner. PI3K/AKT/mTOR, a cancer promoting signaling, was inactivated by Tet in a dose‐dependent manner in BGC‐823 and MKN‐45 cells. Furthermore, our results demonstrated that the inhibition of Tet to PCNA, N‐cadherin, MMP‐2, and MMP‐9 expression was partly rescuedby AKT inhibitor or mTOR inhibitor. In animal experiments, tumor growth was inhibited by Tet administration in a dose‐dependent manner. In conclusion, the current data indicated that Tet had a critical effect on inhibiting BGC‐823 and MKN‐45 cells proliferation, migration, invasion, and tumor growth via regulating PI3K/AKT/mTOR signaling pathway, suggesting that Tet might be a potential treatment for GC.
Comparison of 4D computed tomography and F‐18 fluorocholine PET for localisation of parathyroid lesions in primary hyperparathyroidism: A systematic review and meta‐analysis
Authors: Patel Dhrumil Deveshkumar , Bhattacharjee Samiksha , Pandey Avaneesh Kumar , Kopp Chirag Rajkumar , Ashwathanarayana Abhiram G. , Patel Himani Vinayak , Barnabas Rohit , Bhadada Sanjay Kumar , Dodamani Manjunath Havalappa 
Published: January 2023

AbstractMinimally invasive parathyroidectomy (MIP) is the standard of care for primary hyperparathyroidism (PHPT). Four dimensional computed tomography(4DCT) and F‐18 Fluorocholine positron emission tomography/computed tomography (FCH PET/CT) localize adenomas accurately to perform MIP. We aimed to conduct a systematic review and metanalysis to evaluate the diagnostic performance of 4DCT and FCH PET/CT scan for quadrant wise localisation in PHPT patients and to do head‐to‐head comparison between these two modalities.Design, Patients and Measurement After searching through PubMed and EMBASE databases, 46 studies (using histology as a gold standard) of 4DCT and FCH PET/CT were included.ResultsTotal number of patients included were 1651 and 952 for 4DCT scan (studies n = 26) and FCH PET/CT scan (studies n = 24) respectively. In per patient analysis, FCH PET/CT and 4DCT had pooled sensitivities of 92% (88−94) and 85% (73−92) respectively and in per lesion analysis, 90% (86−93) and 79% (71−84), respectively. In the subgroup with negative conventional imaging/persistent PHPT, FCH PET/CT had comparable sensitivity to 4DCT (84% [74−90] vs. 72% [46−88]). As per patient wise analysis, FCH PET/CT had better detection rates than 4DCT ([92.4 vs. 76.85], odds ratio −3.89 [1.6−9.36] p = .0024) in the subpopulation where both FCH PET/CT and 4DCT were reported.ConclusionBoth 4DCT and FCH PET/CT scan performed well in newly diagnosed patients, patients with persistent disease and in those with inconclusive conventional imaging results. FCH PET/CT scan had a higher pooled sensitivity than 4DCT in detecting patients with PHPT in head to head comparison.
Novel variants in ACTL7A and PLCZ1 are associated with male infertility and total fertilization failure
Authors: Zhao Shuai , Cui Ying , Guo Shunli , Liu Boyang , Bian Yuehong , Zhao Shigang , Chen Zijiang , Zhao Han 
Published: January 2023

AbstractTotal fertilization failure (TFF), which refers to fertilization failure in all mature oocytes, accounting for 5%–10% of in vitro fertilization (IVF) cycles and 1%–3% of intracytoplasmic sperm injection (ICSI) cycles in human. In this study, we recruited three unrelated primary infertile men with repeated cycles of TFF and performed whole‐exome sequencing to identify the potential pathogenic variants. We identified homozygous or compound‐heterozygous variants of paternal‐effect genes ACTL7A and PLCZ1 that followed a Mendelian recessive inheritance pattern. Novel homozygous nonsense variant in ACTL7A [c.C146G: p.S49*] was identified in case 1, who came from a consanguineous family. Ultrastructural observation of ACTL7A‐mutated spermatozoa by transmission electron microscopy (TEM) indicated that apparent increased thickness of perinuclear matrix and the acrosome was detached from the nuclear envelop. Besides, two novel compound‐heterozygous variants in PLCZ1 were identified in case 2 [c.1174+3A>C:p.?; c.A1274G:p.N425S] and case 3 [c.136‐1G>C:p.?; c.G1358A:p.G453D]. Mutated spermatozoa from case 2 with reduced expression of PLCZ1 showed apparent acrosome detachment by TEM analysis. And ICSI with assisted oocyte activation (ICSI‐AOA) treatment can partly rescue the TFF. Taken together, our findings revealed that novel biallelic variants in the paternal‐effect genes ACTL7A and PLCZ1 were associated with human TFF, which expanding the spectrum of genetic causes and facilitating the genetic diagnosis of male infertility with TFF.
Connecting research and practice to enhance the evolutionary potential of species under climate change
Authors: Thompson Laura M. , Thurman Lindsey L. , Cook Carly N. , Beever Erik A. , Sgrò Carla M. , Battles Andrew , Botero Carlos A. , Gross John E. , Hall Kimberly R. , Hendry Andrew P. , Hoffmann Ary A. , Hoving Christopher , LeDee Olivia E. , Mengelt Claudia , Nicotra Adrienne B. , Niver Robyn A. , Pérez‐Jvostov Felipe , Quiñones Rebecca M. , Schuurman Gregor W. , Schwartz Michael K. , Szymanski Jennifer , Whiteley Andrew 
Published: January 2023

AbstractResource managers have rarely accounted for evolutionary dynamics in the design or implementation of climate change adaptation strategies. We brought the research and management communities together to identify challenges and opportunities for applying evidence from evolutionary science to support on‐the‐ground actions intended to enhance species' evolutionary potential. We amalgamated input from natural‐resource practitioners and interdisciplinary scientists to identify information needs, current knowledge that can fill those needs, and future avenues for research. Three focal areas that can guide engagement include: (1) recognizing when to act, (2) understanding the feasibility of assessing evolutionary potential, and (3) identifying best management practices. Although researchers commonly propose using molecular methods to estimate genetic diversity and gene flow as key indicators of evolutionary potential, we offer guidance on several additional attributes (and their proxies) that may also guide decision‐making, particularly in the absence of genetic data. Finally, we outline existing decision‐making frameworks that can help managers compare alternative strategies for supporting evolutionary potential, with the goal of increasing the effective use of evolutionary information, particularly for species of conservation concern. We caution, however, that arguing over nuance can generate confusion; instead, dedicating increased focus on a decision‐relevant evidence base may better lend itself to climate adaptation actions.
Gut microbiota dysbiosis in Parkinson disease: A systematic review and pooled analysis
Authors: Kleine Bardenhorst Sven , Cereda Emanuele , Severgnini Marco , Barichella Michela , Pezzoli Gianni , Keshavarzian Ali , Desideri Alessandro , Pietrucci Daniele , Aho Velma T. E. , Scheperjans Filip , Hildebrand Falk , Weis Severin , Egert Markus , Karch André , Vital Marius , Rübsamen Nicole 
Published: January 2023

AbstractBackground and purposeThe role of the gut microbiome in the pathogenesis of Parkinson disease (PD) is under intense investigation, and the results presented are still very heterogeneous. These discrepancies arise not only from the highly heterogeneous pathology of PD, but also from widely varying methodologies at all stages of the workflow, from sampling to final statistical analysis. The aim of the present work is to harmonize the workflow across studies to reduce the methodological heterogeneity and to perform a pooled analysis to account for other sources of heterogeneity.MethodsWe performed a systematic review to identify studies comparing the gut microbiota of PD patients to healthy controls. A workflow was designed to harmonize processing across all studies from bioinformatics processing to final statistical analysis using a Bayesian random‐effects meta‐analysis based on individual patient‐level data.ResultsThe results show that harmonizing workflows minimizes differences between statistical methods and reveals only a small set of taxa being associated with the pathogenesis of PD. Increased shares of the genera Akkermansia and Bifidobacterium and decreased shares of the genera Roseburia and Faecalibacterium were most characteristic for PD‐associated microbiota.ConclusionsOur study summarizes evidence that reduced levels of butyrate‐producing taxa in combination with possible degradation of the mucus layer by Akkermansia may promote intestinal inflammation and reduced permeability of the gut mucosal layer. This may allow potentially pathogenic metabolites to transit and enter the enteric nervous system.
From facts and political objectives to legal bases and legal provisions: Incremental European integration in the criminal law field
Authors: Franssen Nicholas , Weyembergh Anne 
Published: January 2023

AbstractThis contribution intends to show that normative foundations, in the sense of foundations prescribing norms or expressing prescriptions, have been rather limited in determining or defining the legal bases, legal provisions and their evolution in EU criminal law. EU primary and secondary law in penal matters has indeed been adopted mainly in reaction to the need to adjust to reality, to face challenges, react to facts, incidents and threats and to implement overwhelmingly political objectives, which themselves follow most of the time from the said factual or operational needs resulting from practice. This thus calls for an assessment of the advantages and risks of the relatively decisive role of external factors on the development of criminal justice in the EU.
Women and girls with haemophilia: A retrospective cohort study in China
Authors: Zhang Wenhui , Li Kuixing , Poon Man‐Chiu , Zhang Xinsheng , Wu Jingsheng , Zhao Xielan , Zhou Min , Wang Xuefeng , Zhang Mei , Xu Weiqun , Yang Linhua , Huang Meijuan , Jin Chenghao , Wang Xiaomin , Zhang Donglei , Chen Lingling , Liu Wei , Zhang Lei , Xue Feng , Yang Renchi 
Published: January 2023

AbstractIntroductionWomen and girls with haemophilia (WGH) may have spontaneous/traumatic bleeding similar to that in males with haemophilia, and in addition excessive bleeding during menstruation and delivery.AimTo characterize WGH in China and provide guidance for better management.MethodsWe retrospectively analysed the characteristics of WGH registered in the Haemophilia Treatment Center Collaborative Network of China (HTCCNC) Registry, including demographics, diagnosis and treatment, bleeding characteristics, obstetrical and gynaecological experiences, and surgical history.ResultsA total of 61 females had confirmed haemophilia. Diagnosis and treatment were typically delayed, longer in mild haemophilia than in severe and moderate. The most frequently reported bleeding manifestations were haemarthrosis in severe and moderate patients, and cutaneous bleeding in mild patients. Among 45 postmenarcheal WGH, 21 (46.7%) had history of heavy menstrual bleeding, but only three received treatments. Prenatal diagnosis and management of perinatal haemorrhage were inadequate. Of 34 deliveries in 30 women, nine deliveries were complicated by postpartum haemorrhage, and 22 offspring carried mutations causing haemophilia. Forty‐four surgical procedures were performed in 29 patients. Those procedures receiving preoperative coagulation factors coverage were significantly less likely to have excessive bleeding than those who did not (P = .003).ConclusionThis is the first and largest study describing WGH in China. There are currently deficiencies in the identification, diagnosis, and management of these patients. Improving health insurance policies, establishing haemophilia centres, and multidisciplinary teams for bleeding and perinatal or perioperative management will help reduce morbidity and mortality.
Vulvar squamous cell carcinoma arising on human papillomavirus‐independent precursors mimicking high‐grade squamous intra‐epithelial lesion: a distinct and highly recurrent subtype of vulvar cancer
Authors: Carreras‐Dieguez Núria , Saco Adela , del Pino Marta , Pumarola Clàudia , del Campo Ricardo López , Manzotti Carolina , Garcia Adriana , Marimon Lorena , Diaz‐Mercedes Sherley , Fuste Pere , Rodrigo‐Calvo Maria Teresa , Vega Naiara , Torné Aureli , Rakislova Natalia 
Published: January 2023

AimsEach category of vulvar squamous cell carcinoma (VSCC), human papillomavirus (HPV)‐associated and HPV‐independent, arises on a specific intra‐epithelial precursor: high‐grade squamous intra‐epithelial lesions (HSIL) and differentiated vulvar intra‐epithelial neoplasia (dVIN), respectively. However, a subset of HPV‐independent VSCC arises on an intra‐epithelial precursor closely mimicking HSIL. We aimed to explore the clinicopathological features of the HPV‐independent tumours with HSIL‐like lesions and compare them with HPV‐independent VSCC with dVIN and HPV‐associated tumours with HSIL.Methods and resultsWe retrospectively identified 105 cases of surgically treated VSCC with adjacent intra‐epithelial precursors. The cases were classified into three groups based on the HPV status and the adjacent precursor identified: (i) HPV‐associated VSCC with HSIL (n = 26), (ii) HPV‐independent VSCC with dVIN lesions (n = 54) and (iii) HPV‐independent VSCC with HSIL‐like lesions (n = 25). We analysed the histological and clinical features including the recurrence‐free survival and disease‐specific survival in the three groups. Patients with HPV‐independent VSCC with HSIL‐like lesions and with dVIN were older than patients with HPV‐associated VSCC (76 and 77 versus 66 years, respectively, P < 0.001). HPV‐independent VSCC with HSIL‐like lesions recurred more frequently [hazard ratio (HR) = 3.87; P < 0.001] than HPV‐independent VSCC with dVIN (HR = 2.27; P = 0.1) and HPV‐associated VSCC (HR = 1). In the multivariate analysis, HPV‐independent VSCC with HSIL‐like lesions remained significant for recurrence. No differences in disease‐specific survival were observed between the three groups.ConclusionsEven though VSCC with HSIL‐like lesions are not associated with higher mortality, they are more likely to recur and might benefit from more intensive treatment strategies and closer surveillance after treatment.