bluuebunny/crossref_metadata_2025_split huggingface dataset:
In situ Injectable Tetra‐PEG Hydrogel Bioadhesive for Sutureless Repair of Gastrointestinal Perforation†
Authors: Li Shurong , Xian Yiwen , He Gang , Chen Luyuan , Chen Zhihui , Hong Yonglong , Zhang Chong , Wu Decheng 
Published: July 2023

Comprehensive SummaryHydrogel bioadhesives represent promising and efficient alternatives to sutures or staples for gastrointestinal (GI) perforation management. However, several concerns remain for the existing bioadhesives including slow and/or weak adhesive, poor mechanical strength, low biocompatibility, and poor biodegradability, which largely limit their clinical application in GI perforation repair. In this work, we introduce an in situ injectable Tetra‐PEG hydrogel bioadhesive (SS) composed of tetra‐armed poly(ethylene glycol) amine (Tetra‐PEG‐NH2) and tetra‐armed poly(ethylene glycol) succinimidyl succinate (Tetra‐PEG‐SS) for the sutureless repair of GI defects. The SS hydrogel exhibits rapid gelation behavior and high burst pressure and is capable of providing instant robust adhesion and fluid‐tight sealing in the ex vivo porcine intestinal and gastric models. Importantly, the succinyl ester linkers in the SS hydrogel endow the bioadhesive with suitable in vivo degradability to match the new GI tissue formation. The in vivo evaluation in the rat GI injured model further demonstrates the successful sutureless sealing and repair of the intestine and stomach by the SS hydrogel with the advantages of neglectable postsurgical adhesion, suppressed inflammation, and enhanced angiogenesis. Together, our results support potential clinical applications of the SS bioadhesive for the high‐efficient repair of GI perforation.
Different electrophysiological characteristics of cavo‐tricuspid isthmus dependent atrial flutter guided by robotic magnetic navigation in patients with and without prior cardiac surgery
Authors: Luo Qingzhi , Xie Yun , Bao Yangyang , Wei Yue , Lin Changjian , Zhang Ning , Ling Tianyou , Chen Kang , Pan Wenqi , Wu Liqun , Jin Qi 
Published: July 2023

AbstractBackgroudCavo‐ tricuspid isthmus dependent atrial flutter (CTI‐ AFL) is a common atrial arrhythmia in patients with prior cardiac surgery (postsurgical AFL) and without prior cardiac surgery (nonsurgical AFL). However, there is only limited data regarding the eletrophysiological differences between the CTI‐ AFL in the postsurgical patients and the nonsurgical patients.HypothesisWe aimed to investigate the differences in clinical and electrophysiological characteristics between the postsurgical group and nonsurgical group and to evaluate the acute and long‐term outcomes after ablation guided by robotic magnetic navigation (RMN) in both the groups. Methods Fourty‐two consecutive patients with nonsurgical AFL and 21 with postsurgical AFL were retrospectively analyzed in our center. Electrocardiographic (ECG) analysis and three‐dimensional electrophysiological study were performed in all the patients.ResultsThe results revealed that only 55.6% of postsurgical patients with proven counterclockwise (CCW) AFL presented with a typical ECG suggesting this mechanism. In contrast, 86.1% of nonsurgical patients demonstrated a typical ECG pattern for CCW AFL. In addition, we employed a reverse “U‐curve” to facilitate radiofrequency delivery when ablating near the inferior vena cava ostium in the present study. Compared with the nonsurgical group, electroanatomical mapping showed the mean AFL cycle length was significantly longer (253.3 ± 40.4 vs. 234.1 ± 24.2 ms, p = 0.03) and the right atrium volume was larger (114.8 ± 26.0 vs. 97.5 ± 19.1 mL, p = 0.004) in the postsurgical group. Additionally, the procedural time (75.9 ± 21.3 vs. 61.6 ± 26.6 minutes, p = 0.03) and ablation time (53.0 ± 21.4 vs. 36.7 ± 25.6 minutes, p = 0.02) are much longer in the postsurgical group. However, the navigation index in the postsurgical group was significantly smaller (0.35 ± 0.08 vs. 0.43 ± 0.13, p = 0.01). Moreover, the acute and long‐term success rates were comparable between the two groups.ConclusionsCatheter ablation of CTI‐AFL with and without prior cardiac surgery guided by RMN are associated with high acute and long‐term success rates, despite the procedural and ablation times are much longer in the postsurgical patients. However, ECG characteristics of the tachycardia may be misleading as they are more often atypical in patients after cardiac surgery.
Secular trends of health care resource utilization and costs between Brugada syndrome and congenital long QT syndrome: A territory‐wide study
Authors: Lee Sharen , Chung Cheuk To Skylar , Radford Danny , Chou Oscar Hou In , Lee Teddy Tai Loy , Ng Zita Man Wai , Roever Leonardo , Rajan Rajesh , Bazoukis George , Letsas Konstantinos P. , Zeng Shaoying , Liu Fang Zhou , Wong Wing Tak , Liu Tong , Tse Gary 
Published: July 2023

AbstractBackgroundHealth care resource utilization (HCRU) and costs are important metrics of health care burden, but they have rarely been explored in the setting of cardiac ion channelopathies.HypothesisThis study tested the hypothesis that attendance‐related HCRUs and costs differed between patients with Brugada syndrome (BrS) and congenital long QT syndrome (LQTS).MethodsThis was a retrospective cohort study of consecutive BrS and LQTS patients at public hospitals or clinics in Hong Kong, China. HCRUs and costs (in USD) for Accident and Emergency (A&E), inpatient, general outpatient and specialist outpatient attendances were analyzed between 2001 and 2019 at the cohort level. Comparisons were made using incidence rate ratios (IRRs [95% confidence intervals]).ResultsOver the 19‐year period, 516 BrS (median age of initial presentation: 51 [interquartile range: 38−61] years, 92% male) and 134 LQTS (median age of initial presentation: 21 [9−44] years, 32% male) patients were included. Compared to LQTS patients, BrS patients had lower total costs (2 008 126 [2 007 622−2 008 629] vs. 2 343 864 [2 342 828−2 344 900]; IRR: 0.857 [0.855−0.858]), higher costs for A&E attendances (83 113 [83 048−83 177] vs. 70 604 [70 487−70 721]; IRR: 1.177 [1.165−1.189]) and general outpatient services (2,176 [2,166−2,187] vs. 921 [908−935]; IRR: 2.363 [2.187−2.552]), but lower costs for inpatient stay (1 391 624 [1 391 359−1 391 889] vs. 1 713 742 [1 713 166−1 714 319]; IRR: 0.812 [0.810−0.814]) and lower costs for specialist outpatient services (531 213 [531 049−531 376] vs. 558 597 [558268−558926]; IRR: 0.951 [0.947−0.9550]).ConclusionsOverall, BrS patients consume 14% less health care resources compared to LQTS patients in terms of attendance costs. BrS patients require more A&E and general outpatient services, but less inpatient and specialist outpatient services than LQTS patients.
Social isolation and social connectedness among young adult cancer survivors: A systematic review
Authors: Fox Rina S. , Armstrong Grace E. , Gaumond Julia S. , Vigoureux Taylor F. D. , Miller Corinne H. , Sanford Stacy D. , Salsman John M. , Katsanis Emmanuel , Badger Terry A. , Reed Damon R. , Gonzalez Brian D. , Jim Heather S. L. , Warner Echo L. , Victorson David E. , Oswald Laura B. 
Published: July 2023

AbstractBackgroundSocial isolation and connectedness are social determinants of health that have demonstrated effects on cancer‐related outcomes. These constructs have been systematically evaluated among pediatric and older adult cancer populations. In this review, the authors evaluated the prevalence, correlates, and psychosocial implications of social isolation and connectedness among young adult (YA) cancer survivors aged 18–39 years.MethodsPeer‐reviewed articles published in English before June 2021 were identified from database searches and included articles' reference lists according to PRISMA (Preferred Reporting Items for Systematic Reviews and Meta‐Analyses) guidelines. Included articles described studies that assessed social isolation and/or connectedness among YA cancer survivors.ResultsIn total, 5094 unique records were identified; 4143 were excluded after title/abstract screening, and 907 were excluded after full‐text review. Forty‐four articles were included. Few studies used validated measures or directly assessed social isolation or connectedness. Social isolation was similarly prevalent among YAs and older cancer survivors and noncancer populations. Demographic, clinical, and behavioral risk and protective factors for social isolation were identified. Social isolation was related to worse psychological well‐being, whereas social connectedness was often, but not always, related to better psychological well‐being.ConclusionsThis growing literature underscores the relevance of social isolation and connectedness as important health determinants among YA cancer survivors. The identified risk and protective factors can identify YAs who especially may benefit from screening for social isolation. Future studies are needed that directly, reliably, and validly evaluate social isolation and connectedness to inform the development of interventions to decrease isolation and increase connectedness.
Characterization of neurotransmitter inhibition for seven cathinones by a proprietary fluorescent dye method
Authors: Persson Mattias , Vikingsson Svante , Kronstrand Robert , Green Henrik 
Published: July 2023

AbstractMany new psychoactive substances (NPS) are stimulants, and information about their potency and abuse potential is often lacking. To start addressing this need, a method measuring the inhibition of the dopamine, serotonin, and norepinephrine transporters (DAT, SERT, and NET) by stimulant drugs was developed. The use of a proprietary fluorescent dye mixture and three cell lines (CHO‐K1, HEK 293, and MDCK), each expressing a single transporter, allowed for a semiautomated, one‐pot determination of inhibition in a 384‐well format. The method was validated using well characterized stimulants, including cocaine, amphetamine, 3,4‐methylenedioxymethamphetamine (MDMA), α‐PVP, and fluoxetine and performed similarly to other methods. Seven synthetic cathinones all showed highest potency for DAT inhibition, followed by NET and SERT. The rank potency for DAT inhibition IC50 (nM) was MPHP (4.53) > 4Cl‐α‐PVP (8.05) > 3F‐α‐PVP (12.7) > α‐PiHP (13.4) > N‐ethylpentylone (16.9) > N‐ethylhexedrone (44.5) > 4‐methylpentedrone (261). All but 4‐methylpentedrone were more potent than amphetamine (257) and cocaine (111). The DAT/SERT inhibition ratio for the cathinones was in the range from 5.02 for 4‐methylpentedrone to >3730 for α‐PiHP, compared to 1.64 for cocaine and >4030 for α‐PVP. All seven substances had inhibition profiles similar to those of potent stimulants with high abuse potential.
Cerium(IV) Nitrate Complexes With Bidentate Phosphine Oxides
Authors: Coles Simon J. , Cooper Simon , Klooster Wim T. , McCormick Mc Pherson Laura J , Platt Andrew W. G. 
Published: July 2023

AbstractThe reactions between ceric ammonium nitrate, (NH4)2Ce(NO3)6, (CAN) and the bidentate phosphine oxides, 4,5‐bis(diphenylphosphine oxide)‐9,9‐dimethylxanthene (L1), oxydi‐2,1‐phenylene bis(diphenylphosphine dioxide) (L2), 1,2‐bis(diphenylphosphino)ethane dioxide (L3) and 1,4‐bis(diphenylphosphino)butane dioxide, L4 have been investigated. The crystal structures of the molecular Ce(NO3)4L1 (1), and ionic [Ce(NO3)3L32][NO3]⋅CHCl3 (3), [Ce(NO3)3L32][NO3] (4) and the polymeric [Ce(NO3)3L41.5] [NO3] (5) and the cerium(III) complex [Ce(NO3)2L12][NO3] (2) are reported. The thermal stability of the complexes has been examined by thermogravimetry with the gaseous decomposition products analysed by infrared spectroscopy. Evolution of CO2 is found for both Ce(III) and Ce(IV) complexes with the later also forming NO2. The formation of the complexes in solution has been studied by 31P NMR spectroscopy and further complexes [Ce(NO3)3L12]+[NO3]− and [Ce(NO3)2L13]2+2[NO3]− identified in CD3CN solution. The complex (1) exists as a single molecular species in solution and is stable in dichloromethane whilst (3) decomposes on standing in both CD2Cl2 and CD3CN to Ce(III) containing species. Complexes of L2 have been identified by solution 31P NMR spectroscopy and these decompose in solution to give Ce(NO3)3L22. This study represents the first structural characterisations of Ce(IV) complexes with bidentate phosphine oxides.
Insights into coconut oil's anti‐obesity potential: In vitro modulation of lipidic accumulation, adipolysis, and immune response
Authors: Machado Manuela , Rodriguez‐Alcalá Luís M. , Pintado Manuela , Gomes Ana Maria 
Published: July 2023

AbstractThe purpose of this work was to evaluate coconut oil's effect on lipid metabolism‐related diseases and immune response using in vitro models. The coconut oil doses were selected according to the results of the safety evaluation performed through genotoxicity and cytotoxicity tests. Then its capacity to modulate obesity‐related metabolism was evaluated by measuring adipolysis in 3T3‐L1 differentiated adipocytes and hepatic lipid accumulation in hepatocytes (Hep G2). The immunomodulatory activity was evaluated using Caco‐2 cells and quantifying pro‐inflammatory cytokines’ production (IL‐6, IL‐8, and TNF‐α). Coconut oil, mainly comprised of medium‐chain fatty acids (>60% of total fatty acids), showed a high antioxidant capacity (125.76 ± 11.63 µM trolox equivalent/mL). The results showed that coconut oil was capable of reducing 68% of the lipid accumulation in hepatocytes and 42% in adipocytes. It was also capable of modulating the immune response in IL‐1β Caco‐2 stimulated cells, reducing IL‐6 secretion (22% in the presence of 10 mg/mL of coconut oil and by 19% when 15 mg/mL) and TNF‐α secretion (90% and 42% in the presence of 15 or 10 mg/mL of coconut oil, respectively). In short, coconut oil shows great potential for the development of functional foods and nutraceuticals targeting lipid metabolism‐related diseases.Practical applications: This study describes the impact of organic virgin coconut oil on obesity‐related metabolism and immune response. Despite the high content of saturated fatty acids, this vegetable oil has several beneficial effects in the obesity context by the reduction of lipid accumulation.Coconut oil can reduce lipid accumulation in hepatocytes and adipocytes.Coconut oil is capable of modulating the immune response in gut cells.
Concomitant use of dupilumab with glucocorticoid in bullous pemphigoid reduces disease severity: A preliminary study
Authors: Hu Lingyu , Huang Ruiting , Jiang Fuqiong , You Shuqiong , Wu Qian 
Published: July 2023

AbstractObjectiveTo retrospectively analyze the efficacy and safety of dupilumab in the treatment of bullous pemphigoid.MethodsFrom October 2020 to October 2022, the medical records of patients with bullous pemphigoid who were treated with dupilumab in our department were collected retrospectively to analyze the therapeutic effect and changes in laboratory indexes.ResultsThe records of a total of 11 patients with bullous pemphigoid who were treated with dupilumab was reviewed. Within 2 weeks of the treatment, 10 (90.9%) of the 11 patients had complete or substantial control of the disease. The BPDAI scores of the patients decreased from baseline 113 (62, 181) to 37 (6, 130) at 2 weeks (p = .001) and 4 (0, 37) at 12 weeks after treatment (p < .001). In the 11 patients treated with dupilumab, the relief time of pruritus was 0–3 days (0.5, 7) days, and the pruritus was significantly alleviated after 2 weeks (t = 15.925, p < .001). The DLQI score decreased from (25.5 ± 2.5) before treatment, to (11.8 ± 4.4) at 2 weeks (t = 10.764, p < .001) and (2.1 ± 1.9) at 12 weeks (t = 30.038, p < .001). The patients had high eosinophil counts, high serum IgE levels, low serum total protein levels, and abnormal blood coagulation function. The aforementioned indicators gradually returned to normal after treatment. No adverse reactions occurred during the treatment.ConclusionDupilumab can effectively control the condition of bullous pemphigoid, efficiently relieve pruritus symptoms, and is relatively safe.
Systemic lupus erythematosus with diffuse splenic calcification: A case report
Authors: Su Shanshan , Zhong Huohu 
Published: July 2023

AbstractObjectiveSystemic lupus erythematosus (SLE) is a systemic autoimmune disease with the main clinical characteristics of multisystem and multiorgan involvement of the whole body. It is commonly seen in skin mucosa, skeletal muscle, and the respiratory system while rarely involving the spleen. In this case, we present a young female patient with SLE with the symptom of progressing splenic calcification.MethodsA 21–year–old female patient was admitted to our hospital in 2012 with complaints of “fever, abdominal pain, diarrhea, and knee pain”, and then was diagnosed with systemic lupus erythematosus combined with lupus nephritis. The first ultrasound examination was normal in 2012. However, when she returned to the hospital in 2016, she was found to have multiple calcifications in her spleen. After discharge, the patient was treated with commonly used immunosuppressive drugs and was followed up regularly for symptoms of multiple calcifications in the spleen.ResultsSubsequent follow–up over a long period revealed a progressive development of multiple calcifications in the spleen, with a progressive increase in the size and number of calcified foci over time.ConclusionWhen a patient is found to have diffuse splenic calcification on ultrasound, care should be taken to differentiate SLE with multiple splenic calcifications from sarcoidosis, tuberculosis, brucellosis, and rheumatoid arthritis in conjunction with a medical history and relevant laboratory tests.
Using interest rates to predict economic growth: Are corporate bonds better?
Authors: McMillan David G. 
Published: July 2023

AbstractWe consider whether government bonds, through the term structure, or corporate bonds, through the default yield, provide predictive power for output, consumption and investment growth in the United States. Such predictive power will allow policy‐makers to use the information as a leading indicator for macroeconomic performance and will improve our understanding of the links between real and financial markets. Full sample results suggest that both interest rate series exhibit predictive power for each of the macroeconomic growth series. Time‐variation in the predictive coefficient reveals the waning influence of the term structure and the rising influence of the default yield. Forecast results, which are obtained from a rolling window approach, likewise suggest both series have information content for macroeconomic conditions, but there is a change in their relative strengths. These results may arise as interest rates have declined since the highs of the early to mid‐1980s thus reducing the information content of government yields, whereas corporate bonds respond more to investor views of macroeconomic risk, which affects a firm's ability to repay its debt. Furthermore, short‐term rates are largely held unprecedently low since the dotcom crash.
Risk factors for pelvic organ prolapse recurrence following colpocleisis: A meta‐analysis
Authors: Nahshon Chen , Karmakar Debjyoti , Abramov Yoram , Kugelman Nir , Lavie Ofer , Zilberlicht Ariel 
Published: July 2023

AbstractBackgroundStudies aimed to assess risk factors for pelvic organ prolapse (POP) recurrence following colpocleisis with nonconclusive results.ObjectiveTo investigate risk factors for POP recurrence following colpocleisis.Search StrategyMEDLINE, PUBMED, Embase, Web of Science, and Cochrane databases were systematically searched.Selection CriteriaExperimental and non‐experimental studies investigating POP recurrence following colpocleisis.Data Collection and AnalysisWe assessed the association between preoperative and postoperative physical examination findings, demographics and medical history, and the risk of recurrence following colpocleisis.Main ResultsA total of 954 studies were identified, of which five studies comprising 2978 patients were eligible for analysis. Both preoperative and postoperative genital hiatus length were significantly longer in the recurrence group (mean difference [MD] 0.48, 95% confidence interval [CI] 0.01–0.94, P = 0.04, I2 = 0% and MD 1.15, 95% CI 0.50–1.81, P = 0.005, I2 = 0%; respectively). Preoperative total vaginal length (TVL) did not differ between groups (MD 0.05, 95% CI –0.40 to 0.50, P = 0.83, I2 = 6%), postoperative TVL was found significantly longer in the recurrence group (MD 0.07, 95% CI –0.03 to 1.38, P = 0.04, I2 = 68%). Both preoperative and postoperative perineal body did not differ between groups. Women with a previous POP surgery were more likely to experience recurrence following colpocleisis (relative risk 2.09, 95% CI 1.18–3.69, P = 0.01, I2 = 0%). Patient's age and previous hysterectomy did not affect recurrence rates.ConclusionWider preoperative and postoperative genital hiatus as well as longer post‐operative TVL and previous POP surgery were associated with a higher risk for recurrence following colpocleisis, highlighting the importance of appropriate patient selection and surgical technique in minimizing this risk.
Umbilical cord cysts: Classification, diagnosis, prognosis, and pregnancy recommendations
Authors: Chen Huiling , Jia Mingzhu , Yang Shuqi , Zou Juan , Xiao Xue 
Published: July 2023

AbstractUmbilical cord cysts (UCCs)—cysts located in the umbilical cord that are derived from an abnormal embryonic development process—are typically an incidental discovery during prenatal ultrasound. It can be described as either a pseudocyst or a true UCC, which results from focal edema or degeneration of Wharton jelly or the remnants of embryonic development, respectively. Due to the relative rarity of the UCC, the clinical guidance of UCCs is not yet available. Herein, the aim of this paper is to discuss the classification, diagnosis, prognosis, and clinical management of UCCs through a literature review, in order to improve the understanding of UCCs among clinical obstetricians and pediatricians.
Humanized disulfide‐stabilized diabody against fibroblast growth factor‐2 inhibits PD‐L1 expression and epithelial‐mesenchymal transition in hepatoma cells through STAT3
Authors: Sun Huamin , Song Xinran , Li Cunjie , Li Qing , Liu Shifeng , Deng Ning 
Published: July 2023

AbstractFibroblast growth factor 2 (FGF2) plays an important role in tumor angiogenesis. Humanized disulfide‐stable double‐chain antibody against fibroblast growth factor‐2 (anti‐FGF2 ds‐Diabody) is a small molecule antibody with good tissue permeability and low immunogenicity, which has potential in tumor‐targeted therapy. This study intended to investigate the effect of anti‐FGF2 ds‐Diabody on the migration and expression of programmed death‐ligand1 (PD‐L1) in hepatocellular carcinoma (HCC) cells. The anti‐FGF2 ds‐Diabody was expressed under methanol induction and purified with Ni2+‐affinity chromatography. Anti‐FGF2 ds‐Diabody significantly inhibited cell viability and proliferation in SK‐Hep1 and HepG2 cells as confirmed by CCK‐8 assays and colony formation assays. Western blot assays indicated that the proliferation of SK‐Hep1 and HepG2 cells was inhibited by anti‐FGF2 ds‐Diabody through inhibiting the phosphorylation activation of AKT and MAPK. The results of transwell and western blot assays showed that the migration and invasion of SK‐Hep1 and HepG2 cells were suppressed by anti‐FGF2 ds‐Diabody by affecting the epithelial‐mesenchymal transition (EMT) process. Meanwhile, anti‐FGF2 ds‐Diabody inhibited the expression of PD‐L1, and STAT3 participated in this process. Analysis of RT‐PCR and Western blot suggested that fibroblast growth factor receptor 4 inhibitor 1 (FGFR4‐IN‐1) suppressed the expression of PD‐L1, while STAT3 overexpression reversed this inhibitory effect. In addition, overexpression of STAT3 promoted migration and invasion and restored the suppressive effect of anti‐FGF2 ds‐Diabody on EMT. In conclusion, anti‐FGF2 ds‐Diabody could inhibit the expression of PD‐L1 and EMT of hepatoma cells through FGF2/FGFR4/STAT3 axis. These results suggested that anti‐FGF2 ds‐Diabody has potential clinical application in inhibiting metastasis and immune escape of hepatocellular carcinoma.