bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy of combined disinfection with a nitric oxide donor in controlling biofilm formation on the reverse osmosis water pathway for hemodialysis
Authors: Tange Yoshihiro , Murata Ayane , Yoshitake Shigenori 
Published: September 2023

Abstract
The water treatment system for hemodialysis (HD) is used to treat multiple patients requiring HD simultaneously. This system requires a large amount of purified reverse osmosis (RO) water. However, a major drawback of this method is the formation of biofilms in dialysate pathways. The purpose of this study was to investigate the efficacy of NOC 18, a nitric oxide (NO) donor that can be used at neutral pH, in disinfecting the RO water pathway. Silicone tubes were obtained from the terminal sites of two different HD units. The biofilm coverage and mean biofilm thickness on the tube lumen were evaluated by scanning electron microscopy. The results demonstrated that treatment with NOC 18 alone and in conjunction with sodium hypochlorite reduced biofilm coverage and mean biofilm thickness. Thus, NO donor is a potential disinfectant that enhances bacterial dispersion from biofilms formed on the silicone tube lumen and reduces biofilm coverage and thickness on the RO water pathway at neutral pH. Furthermore, combined disinfection with the NO donor and sodium hypochlorite might enhance biofilmremoval efficacy in clinical practice.
Elucidating Anti-aging and Antioxidant Activity of Hydnocarpus anthelmintica
on Skin Aging and Cosmeceutical Potentials: In Silico and
In Vitro Study
Authors: Kim Minjee , Lee Eunji , Kim Young Bong 
Published: September 2023

Introduction::
Hydnocarpus anthelmintica (HA) has been traditionally used for treating
leprosy and is known for its antioxidant and anti-inflammatory activities. The aim of this study was
to investigate the active compounds and targets of HA extracts, involved in oxidative stress and
skin aging. The active compounds and targets of HA extracts were identified using network pharmacology.

Method::
The pathway study was conducted using the Kyoto Encyclopedia of Genes and Genomes
(KEGG) database. HA semen was measured for its in-vitro antioxidant activity using 2,2-diphenyl-
1-picrylhydrazyl (DPPH) assay and anti-aging activities using collagenase, elastase, and tyrosinase
assays. A total of 21 intersecting core targets were identified from 8 compounds, 51 action targets,
and 1810 skin aging and oxidative stress-associated target genes.

Result::
A compound-target network was constructed, and 3 compounds (luteolin, beta-carotene
and genkwanin), and 4 hub genes (TP53, HSP90AA1, JUN, and MAPK1) were identified. The
KEGG pathway study revealed that the compounds were correlated with PI3K-Akt, p53, HIF-1,
and MAPK signaling.

Conclusion::
The results of in-vitro experiments showed the effect of HA extract on oxidative
stress reduction and collagenase inhibition. We discovered two main active compounds, luteolin
and β-carotene, that may be involved in p53 and MAPK signaling, and showed HA extract activity
against oxidative stress and collagenase.
Acyclic Aldehydo Sugars: 1,3-dimethyl-4,5-diamino Uracil as Recoverable
Carbonyl Protecting Group
Authors: Fuentes-Rios D. , Doña M. , López-Romero J.M. , Rico R. 
Published: September 2023

Abstract:
1,3-dimethyl-4,5-diaminouracil has been used as an efficient protecting group for the carbonyl
moiety in sugars by the formation of the imine group. The protection reaction is carried out under
mild conditions, the yields are quantitative in most of the cases, and the protecting group is completely
recovered and reused. After per-acetylation, deprotection is accomplished at room temperature with
aqueous formic acid to produce acyclic acetylated sugars in good global yield.
Tube-first Technique as a Conduit for Easy and Fast Nasal Fiberoptic Intubation
Authors: Shoukry Aktham Adel Ihsan , Sharaf Amr Gabber Sayed 
Published: September 2023

Background:
Classical nasal fiberoptic bronchoscope intubation may be a challenging and lengthy procedure with a 1-10% failure rate.

Objectives:
This study aimed to compare among patients with difficult airway intubation undergoing general anesthesia, the safety, and efficacy of Tube-First (TF) nasal fiberoptic bronchoscope intubation against the Classic (CL) procedure.

Methods:
This single-blinded, parallel-group, randomized trial enrolled 40 adult patients with known difficult airways and scheduled for surgery under general anesthesia. The patients were randomly allocated into two (n=20 each) patient groups. In the CL group, the endotracheal tube and fiberoptic bronchoscope were inserted together through the nostril; in the TF group, the endotracheal tube insertion preceded the fiberoptic bronchoscope. In both groups, the bronchoscope was used to visualize the vocal cords and removed after ensuring the endotracheal tube position. The primary (efficacy) outcomes were the time elapsing from the bronchoscope insertion and visualizing the vocal cords (T1) and the time elapsing from the bronchoscope advancing initiation to its removal (T2). The secondary (safety) outcomes included oxygen saturation and hemodynamic parameters during the procedure.

Results:
The TF group showed a significant T1 and T2 mean reduction compared to those of the CL group (37.15 ± 3.87 and 64.25 ± 8.28 vs. 55.05±4.52 and 88.25±5.49 seconds, respectively; p < 0.0001). The oxygen saturation was comparable in both groups with no desaturation (SpO2 < 90%) cases. The heart rate and mean arterial blood pressure changes were significantly lower in the TF group compared to the CL group.

Conclusion:

Among patients with difficult airway intubation undergoing general anesthesia, we found the Tube-First intubation approach was quicker and safer compared to the classical intubation technique.
Autoimmune Hepatitis in People Living with HIV: A Case Series and Review of Literature
Authors: Laurenda Obeng , Anneka Patel , Giovanni Villa , Adele Mourad , Max Whibley , Yvonne Gilleece , Sumita Verma 
Published: September 2023

Background:
Autoimmune immune disorders are rare in people living with human immunodeficiency virus (HIV), especially autoimmune-related liver disease. Additionally, diagnosis is challenging as there can be multiple reasons for abnormal liver tests in people living with HIV. Since autoimmune hepatitis responds well to immunosuppression and delaying treatment can be detrimental, its diagnosis and treatment must not be delayed or missed. To increase awareness amongst clinicians, thus ensuring prompt diagnosis and treatment, we present three patients with autoimmune hepatitis in the context of people living with HIV.

Case Presentation:
Three individuals aged between 47-63 years (two females and one male) present with significant transaminitis (alanine aminotransferase 5-10 x upper limit of normal), with two out of the three being autoantibody-positive with an elevated IgG. In all three individuals, a liver biopsy was consistent with autoimmune hepatitis and, in addition, showed advanced hepatic fibrosis/cirrhosis. All individuals presented following immune reconstitution. There was a good response to immunosuppression with a reduction in hepatic fibrosis. All are currently in clinical and biochemical remission.

Conclusion:
Autoimmune hepatitis, though rare, must be considered in the differential diagnosis of abnormal liver tests in people living with human immunodeficiency virus. There should be a low threshold to perform a liver biopsy, which can be diagnostic in the right clinical setting. A prompt institution of immunosuppression is warranted to induce remission and attenuate hepatic fibrosis. However, long-term management and outcomes, including the duration of immunosuppression, remain unclear.
PENINGKATAN KETERSEDIAAN FISIK DAN WAKTU RATA-RATA ANTARA KEGAGALAN UNIT KOMATSU PC2000-8 PADA PT. UNITED TRACTORS, TBK DENGAN METODE FMEA
Authors: Rustanto Rustanto , Pratama Aditya Tirta , Febrianto Anggi , Syafutra Firdaus Agung , Septianugraha Willian , Walfitri Badai Merdeka 
Published: September 2023

The era of heavy equipment industry in Indonesia was begun in the mid-1990s, by the first heavy equipment company, PT. United Tractors Tbk. This company have started heavy equipment sales and rental throughout Indonesia, which the well-known heavy equipment is the Hydraulic Excavator. It is used to excavate, rotate, move, load, mobilize and demobilize objects. Since the excavator was always used in the site’s daily operation, the number of failures is high, then the rate of excavator’s physical availability is below the requirement standard. The purpose of this study is to analyze the physical availability of the Komatsu Excavator Komatsu PC2000-8 by reducing the failure on the Boom Attachment by using the FMEA method. In order to obtain the optimum design and conditions as heavy machine, the analytical study was utilized for increasing physical availability on Hydraulic Excavators. According to the estimation of the analytical study, it was found that the highest physical availability of the PC2000-8 Hydraulic Excavator was at 98.4%, with the MTBF (Mean Time Before Failure) was at 269 hours.
ANALYSIS OF CORROSION RATE AND REMAINING LIFE OF STEEL ON PIPELINES AT PKS PTPN 1 TANJUNG SEUMANTOH
Authors: Zulfri Muhammad , Rachman Nazaruddin Abdul , Isra Muhammad 
Published: September 2023

Corrosion is a major cause of early failure in palm oil mill infrastructure in Aceh, Indonesia. Therefore, the aim of this study is to analyze the corrosion rate of steel used in the palm oil mill industry and determine the remaining life of the steel. Round bars and plates made of steel were used as exposure samples. This sample was cleaned of impurities and ground with sandpaper to obtain a 600 grating, then washed with clean water and rinsed with strong liquid, then presented to the climate at the PTPN 1 Tanjung Seumantoh palm oil mill so that it could see the rate of steel erosion due to corrosion. For exposure, steel specimens are placed on racks, and weight measurements are taken once a month to determine corrosion rate values using the ASTM G50 standard. In addition, steel thickness measurements were also carried out in 2021 and 2022 to calculate the corrosion rate using the Standard API 570 standard. Research results of the remaining life of the pipe on the wall tube is about 32 years. the remaining life for the generating pipe is about 29 years, and the remaining life for the heater pipe is about 11 years. from the calculation results obtained the longest remaining life is obtained on the wall pipe while the shortest remaining life of the pipe is found in the heater pipe because the pipe is always heated.
Ruins in the Expanded Field
Authors: Romm Jake 
Published: September 2023

This paper applies the Klein Group form used by Rosalind Krauss in her essay, "Sculpture in the Expanded Field", to the field of ruins. The opposition utilized to create the ruin Klein Group is the opposition between vanished and intact. The paper proceeds by classifying and discussing each of the possibilities opened up by the expanded field: ruins (not-vanished ; not-intact), consecrated sites (vanished ; not-vanished), ruin-reproduction (vanished ; intact), and finally the "necroaesthetical ruin" (intact ; not-intact). The expanded field and the political and aesthetic implications thereof are discussed primarily in conversation with Paolo Virno's "Deja Vu and the End of History," as well as Achille Mbembe's "Necropolitics" and Andreas Huyssen's "Nostalgia for Ruins.”
A Response to “Critical Naturalism: a Manifesto” or Manifesto, Teleology, Transgressing Social Constructionism, and the Insistence of the Human
Authors: Kempen Aldo 
Published: September 2023

The prior issue of Krisis (42:1) published Critical Naturalism: A Manifesto, with the aim to instigate a debate of the issues raised in this manifesto – the necessary re-thinking of the role (and the concept) of nature in critical theory in relation to questions of ecology, health, and inequality. Since Krisis considers itself a place for philosophical debates that take contemporary struggles as starting point, it issued an open call and solicited responses to the manifesto. This is one of the sixteen selected responses, which augment, specify, or question the assumptions and arguments of the manifesto.
Anthropocene Self-Consciousness: Response to “Critical Naturalism: A Manifesto”
Authors: Bernstein Jay 
Published: September 2023

The prior issue of Krisis (42:1) published Critical Naturalism: A Manifesto, with the aim to instigate a debate of the issues raised in this manifesto – the necessary re-thinking of the role (and the concept) of nature in critical theory in relation to questions of ecology, health, and inequality. Since Krisis considers itself a place for philosophical debates that take contemporary struggles as starting point, it issued an open call and solicited responses to the manifesto. This is one of the sixteen selected responses, which augment, specify, or question the assumptions and arguments of the manifesto.
How Critical is "Second Nature"? A Diagnosis and an Antidote
Authors: Carré Louis 
Published: September 2023

The prior issue of Krisis (42:1) published Critical Naturalism: A Manifesto, with the aim to instigate a debate of the issues raised in this manifesto – the necessary re-thinking of the role (and the concept) of nature in critical theory in relation to questions of ecology, health, and inequality. Since Krisis considers itself a place for philosophical debates that take contemporary struggles as starting point, it issued an open call and solicited responses to the manifesto. This is one of the sixteen selected responses, which augment, specify, or question the assumptions and arguments of the manifesto.
The Absolute Contradiction of Self-Determination
Authors: Sandnes Haukedal Rasmus 
Published: September 2023

The prior issue of Krisis (42:1) published Critical Naturalism: A Manifesto, with the aim to instigate a debate of the issues raised in this manifesto – the necessary re-thinking of the role (and the concept) of nature in critical theory in relation to questions of ecology, health, and inequality. Since Krisis considers itself a place for philosophical debates that take contemporary struggles as starting point, it issued an open call and solicited responses to the manifesto. This is one of the sixteen selected responses, which augment, specify, or question the assumptions and arguments of the manifesto.
Usefulness of the Montreal Cognitive Assessment in Older Adults With Type 1 Diabetes
Authors: Choe James , Kudrna Rachel , Fonseca Luciana Mascarenhas , Chaytor Naomi S. 
Published: September 2023

Objective
Older adults with type 1 diabetes are at high risk for cognitive impairment, yet the usefulness of common cognitive screening instruments has not been evaluated in this population.

Methods
A total of 201 adults ≥60 years of age with type 1 diabetes completed a battery of neuropsychological measures and the Montreal Cognitive Assessment (MoCA). Receiver operating characteristic (ROC) curves and Youden indices were used to evaluate overall screening test performance and to select an optimal MoCA cutoff score for detecting low cognitive performance, as defined as two or more neuropsychological test performances ≥1.5 SD below demographically corrected normative data.

Results
The ROC area under the curve (AUC) was 0.745 (P &lt; 0.001). The publisher-recommended cutoff score of &lt;26 resulted in sensitivity of 60.4% and specificity of 71.4%, whereas a cutoff score of &lt;27 resulted in sensitivity of 75.0% and specificity of 61.0%. The Youden indices for these cutoff scores were 0.318 and 0.360, respectively. Minimally acceptable sensitivity (i.e., &gt;0.80) was obtained when using a cutoff score of &lt;28, whereas &gt;0.80 specificity was obtained with a cutoff score of &lt;25.

Conclusions
The MoCA has modest overall performance (AUC 0.745) as a cognitive screening instrument in older adults with type 1 diabetes. The standard cutoff score of &lt;26/30 may not adequately detect individuals with neuropsychological testing–defined abnormal cognition. The optimal MoCA cutoff score (based on the Youden index) was &lt;27/30. A score of &lt;28 resulted in acceptable sensitivity but was accompanied by low specificity (42%). Future studies with a more diverse population are needed to confirm these findings.
Using Community Engagement Methods to Guide Study Protocol Decisions for School-Aged Children With Type 1 Diabetes
Authors: Abadula Fayo , Jordan Lori C. , LeStourgeon Lauren , Jaser Sarah S. 
Published: September 2023

Introduction
Many challenges exist in developing multisite protocols for newly diagnosed children with type 1 diabetes. Our research team engaged community members to increase the likelihood of study success during a planning grant for a longitudinal study aimed at understanding risk and protective factors for neurocognitive function in school-aged children newly diagnosed with type 1 diabetes.

Methods
Two methods were used to obtain caregiver input into study protocol decisions. The first was a survey given to caregivers of children with diabetes (n = 21) about which aspects of the study protocol would make families more or less likely to participate. The second was a Community Engagement (CE) Studio to obtain recommendations from a diverse group of caregivers of children with diabetes (n = 7) on key aspects of recruitment and enrollment.

Results
Results from both the survey and the CE Studio indicated that caregivers were interested and willing to participate in a longitudinal study of this nature. Both methods resulted in similar preferences for the type and amount of compensation, convenient study visits, flexible scheduling options, and receipt of neurocognitive test results. Recommendations from the CE Studio included additional strategies to minimize participant burden and enhance communication around study participation.

Conclusion
Both the feasibility survey and the CE Studio were useful mechanisms to obtain caregiver input during the study’s planning and design phase. Uniquely, the CE Studio approach offers researchers the ability to gain valuable community member input with minimal staff effort.
Involvement and use of European Metrology Programme for Innovation and Research EMPIR in the Czech Metrology Institute – a positive example of the use of European cooperation
Authors: Tesar Jiri , Safarikova Pstroszova Marketa , Weberova Karolina , Mucha Jaroslav 
Published: September 2023

The Czech Metrology Institute (CMI) has been the national metrology institute of the Czech Republic since 1993. The significant development of the CMI's fundamental metrology departments and the gradual growth of the CMI's scientific and research capacities are linked to its successful participation in the European Metrology Research Programme (EMRP) and the European Metrology Programme for Innovation and Research (EMPIR). In total, 28 countries have participated in the EMPIR Programme, with Switzerland, Norway, Serbia, Bosnia and Herzegovina, Turkey and the UK in addition to the EU Member States. The necessary organisational and administrative background for the realisation of the EMPIR Programme was provided by EURAMET e.V., a European Regional Metrology Organisation operated as a non-profit association under German law. The most important benefit of the Programme for the CMI and the Czech Republic is the successful implementation of the research results of individual EMPIR projects. Within the framework of this implementation of the EMPIR results in the CMI, 6 new state measurement standards of the Czech Republic have already been established and another 4 are in the stage of preparation for announcement. Furthermore, 23 new or significantly modified measurement methods have been developed based on the results within the CMI and are now provided as a service by the CMI. Finally, participation in the EMPIR projects has been used to train 42 new CMI scientists in various fields of measurement. If to add to this the use of the results of the former EMRP Programme, it can be concluded that the development of metrology at the CMI over the last 10 years has been strongly conditioned by successful participation in European Metrology Programmes and the ability of the CMI to subsequently apply the results of individual projects to its laboratory practice.
Development of the methodology of energy and environmental safety of Ukraine based on own geothermics
Authors: Starodub Y.P. , Karpenko V.M. , Havrys A.P. , Behen D.A. 
Published: September 2023

The article presents an idea of the project that defines the development of a geothermal power plant methodology based on a single isolated well. It is planned to develop a technical and economic rationale and geological and geophysical aspects of the development of geothermal energy and to obtain data on deposits of geothermal water in the deep.
Extraction of heat from hot rocks at the pits is to be carried out using a special energy carrier, construction of the operating column, and circulation mode.
To create a model in the project, a well is needed with a depth of 4,702 m, temperature at the bottom of 130 °С, an unperforated casing string with a diameter of 245 mm to a depth of 4,500 m, and no formation fluids.
The transfer and transformation of the energy carrier by the working body into electric and hydrogen energy is maintained by ORC (Organic Rankine Cycle).
The development of the methodology includes two stages:
The first stage of the project involves legal preparation at the local and state levels for the use of the land plot and technical means of the drilled well and obtaining licenses and permits for the implementation of the project. It is planned to develop a technical and economic feasibility study for the construction of a geothermal electric station that will generate electricity and hydrogen energy for consumers.
The second stage of the project involves the technical preparation of the well for its use as part of a geothermal power station. Remediation of the well to a depth of 4,500 m is foreseen, as well as the implementation of industrial geophysical studies of the technical condition of the unperforated casing string; conducting preliminary geothermal studies on the stability and thermal productivity of hot rocks.
The authors intend to use results in the oil-and-gas industry, which has deep wells that have completed their purpose for hydrocarbon extraction, as well as in the nuclear, metallurgical, chemical, and many other fields.