bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigation of Clostridium butyricum on atopic dermatitis based on gut microbiota and TLR4/MyD88/ NF-κB signaling pathway
Authors: Yang Xiaojing , Zhao Qian , Wang Xing , Zhang Yiming , Ma Jingyue , Liu Yuanjun , Wang Huiping 
Published: January 2025

Background Probiotics, as common regulators of the gut microbiota, have been used in research to alleviate clinical symptoms of atopic dermatitis (AD). Objective Our research team has previously identified a potential relieving effect of Clostridium butyricum on the treatment of AD, but the specific mechanism of how Clostridium butyricum alleviates AD has not yet been confirmed. Methods In this study, we explored the relieving effect of Clostridium butyricum on AD through in vivo and in vitro experiments. AD mice induced by 2,4-dinitrofluorobenzene (DNFB) were orally administered with 1 × 108 CFU of Clostridium butyricum for three consecutive weeks. Results Oral administration of Clostridium butyricum reduced ear swelling, alleviated back skin lesions, decreased mast cell and inflammatory cell infiltration, and regulated the levels of inflammation-related cytokines. Clostridium butyricum activated the intestinal immune system through the TLR4/MyD88/NF-κB signaling pathway, suppressed the expression of inflammatory factors IL-10 and IL-13, and protected the damaged intestinal mucosa. Conclusion Clostridium butyricum administration improved the diversity and abundance of the gut microbiota, enhanced the functionality of the immune system, and protected the epidermal barrier.
Exparel and Outpatient Alveolar Bone Grafting: A Feasibility Study
Authors: Muller John N. , Perez Rivera Lucas R. , Staffenberg David A. , Flores Roberto L. 
Published: January 2025

Objectives To examine the feasibility of outpatient alveolar bone grafting (ABG) using Exparel (bupivacaine liposome injectable suspension) for donor site analgesia. Design Retrospective, observational study. Setting Single institution, 39-month retrospective review. Patients/Participants In total, 21 patients with cleft alveolus were included in this study. Intervention In autologous outpatient ABG procedures using a mixed open harvest and Acumed trephine method to retrieve corticocancellous bone from the iliac crest, Exparel was injected in the donor site fascia. Main Outcome Measurements Postoperative data including length of stay, post anesthesia care unit narcotics delivered, and maximum pain scores were recorded. Successful outcomes were assessed by exploring 30-day complications, 30-day emergency department visits, 30-day readmissions, and ambulation at follow-up. Results The average hospital length of stay was 360.8 min. Four patients required overnight stay secondary to pain. The average doses of pain medications administered postoperatively were 198.4 mg acetaminophen, 9.3 mg ketorolac, 3.0 µg fentanyl, and 1.5 mg oxycodone. No patient reported 30-day complications secondary to donor site pain, 30-day emergency department visits, or 30-day readmissions, and there was only one case of wound dehiscence. All patients exhibited proper ambulation at follow-up and healed well from ABG. Conclusions The use of Exparel for donor site analgesia in outpatient ABG procedures using corticocancellous grafts can result in adequate pain management and ambulation without an increased risk of complications and readmissions.
Paramagnetic rim lesion formation is predicted by the initial gadolinium-enhancing lesion diameter
Authors: Al Gburi Mustafa , Mazzola Maria , Absinta Martina , Gaitán María I , Reich Daniel S , Dundamadappa Sathish K , Hemond Christopher C 
Published: January 2025

Background: Paramagnetic rim lesions (PRLs) are a magnetic resonance imaging (MRI) marker of compartmentalized intraparenchymal inflammation. Objectives: The primary objective was to investigate clinical, demographic, and MRI factors that may be predictive of the future formation of PRL. Methods: This is a retrospective analysis of longitudinal data. Patients were included if they had ⩾1 gadolinium-enhancing lesion on any historical MRI and follow-up scan(s) ⩾6 months afterward on a standardized 3T MRI using the filtered phase component of a susceptibility-sensitive sequence (“SWAN”). Regression and machine-learning models were used to identify the predictive ability of demographic, clinical, immunological, treatment-related, and MRI predictors of PRL formation. Results: A total of 64 patients having 229 contrast-enhancing lesions (CELs) were included. Among all predictors, the diameter of the initial enhancing lesion was the most influential for determining subsequent PRL formation; every millimeter increase in diameter increased the risk of PRL formation by 44%. Other factors did not contribute additional information; the administration of steroids was not associated with any effect. Conclusions: The long-axis diameter of a CEL is the best translational predictor of subsequent PRL formation at follow-up. This measure holds promise as a method to identify patients at high risk of chronic active lesion formation during the acute inflammatory window.
The cyclicity of reborrowing and the ping-pong effect: The case of Arabic–Hebrew–Arabic ṣabāba/sababa ‘ok’
Authors: Bardenstein Ruti , Ben-Barry Faten 
Published: January 2025

Aims and objectives: The nature of the effect of language contact has been a source for extensive investigation in the linguistic field. More specifically, the case of reborrowing, that is, the shift from language A to language B and then cyclically back to language A, often involving a change in meaning and/or form, has been a source for extensive interest. In this paper, we examined the word ṣabāba/sababa ‘o.k’ as a case study of reborrowing from Classical Arabic into Israeli Hebrew and then back to Spoken Palestinian Arabic. We show that while language contact does motivate and affect change, it does not necessarily take part in internal changes exhibited in the target language itself, but can, in turn, later be exhibited back in the original language or one of its dialects. In addition, as language-contact change operates according to more general principles of linguistic change, such as grammaticalization, we shall demonstrate both intra- and inter-language changes. Methodology and data: We used the Lisān al-ʿArab (لسان العرب, ‘Tongue of Arabs’) dictionary for the etymological investigation in Arabic,1 the corpus of the Quran for historical Arabic data, scripts and poems from the Mamluk Arabic period for the Middle Ages’ Arabic data,2 and for contemporary spoken Arabic, we used a corpus of 100 random WhatsApp messages of Israeli Arab Bedouin students (such usage exists in all Palestinian Arabic dialects). For the Hebrew data, we used the Israeli Historical Jpress Corpus3 and the Hebrew Historical Maagarim corpus;4 and finally, for contemporary Hebrew data, we used 100 random examples from the hetenten corpus.5 Analysis: We found a reborrowing ‘ping pong effect’, from classical Arabic to 20th-century Hebrew, and in the contemporary 21st century back to Spoken Palestinian Arabic. We also found a phonetic change from Classical Arabic ṣabāba صَباَبة to Contemporary Arabic sababa صبابا. A similar phonetic change occurred in Hebrew, from sabaaba סבאבה to sababa סבבה. Thus, this was not a diachronic shift from Classical Arabic to Spoken Arabic, but rather the classical Arabic word was borrowed into Hebrew and then, in a ‘ping-pong’ reborrowing shift, went back to spoken Arabic. This process involved mechanisms of metonymy, bridging contexts, and lexicalization. Conclusions: While language contact does motivate and affect change, it does not necessarily occur through internal changes exhibited in the target language itself but rather can be transferred back, in a cyclical fashion, to the original language. These results focused on a bilingual community, shedding additional light on the nature of linguistic processes of reborrowing and language contact.
Clinical Outcomes and Financial Impact of a POEM Program at a Rural Tertiary Medical Center: Our First five Years
Authors: Bethea Joseph , Peine Brandon , Fleming Tyler , Mendes Jesse , Olatidoye Olajide , Allman Robert , Oliver Aundrea , Iannettoni Mark , Speicher James , Anciano Carlos 
Published: January 2025

Objective: The purpose of this study was to assess the 5-year impact of a per oral endoscopic myotomy (POEM) program on both clinical and financial outcomes for our hospital system and the rural community we serve. Methods: We evaluated the clinical and financial outcomes of all patients who underwent POEM for achalasia. Patients were also contacted by phone to complete the Gastroesophageal Reflux Disease-Health Related Quality of Life (GERD-HRQL) questionnaire postoperatively. Financial data for all robot-assisted laparoscopic Heller myotomy patients from our institution during the same period were also obtained for cost comparison. Results: A total of 107 patients underwent POEM in the first 5 years following program implementation, with a mean age of 61.4 ± 17.9 years. There were 75 patients (70%) who participated in the GERD-HRQL survey at a mean follow-up of 84 weeks (range, 6 to 244 weeks). There were 88.2% of respondents who reported no or minimal dysphagia symptoms, and 93.4% of respondents reported no or minimal reflux symptoms. On postoperative upper endoscopy, 19.1% of patients had esophagitis. Implementation of the POEM program resulted in a substantial increase in case volume, growing from 5 myotomy cases per year to 24 myotomy cases per year after 2017. Cost analysis demonstrated a significantly lower index encounter cost for POEM compared with robot-assisted laparoscopic Heller myotomy of approximately $6,000. Conclusions: This study demonstrates the effectiveness and positive financial impact for both our community and hospital system following implementation of a POEM program at a tertiary medical center serving a large, rural population.
The “CUPCAKE” technique (coiled underlying pseudoaneurysm contained by a woven endobridge device) for treating intracranial aneurysms with atypical morphology
Authors: Vainauskaite Viktorija , Ren Yifan , Nasra Mohamed , Pavlin-Premrl Davor , Protto Sara , Siasat Paul , Khabaza Ali , Jhamb Ashu , Barras Christen , Gan Calvin , Motyer Ronan , Smith Paul , Moore Justin , Russell Jeremy , Slater Lee-Anne , Chandra Ronil , Brooks Mark , Chong Winston , Maingard Julian , Asadi Hamed 
Published: January 2025

Background Intrasaccular flow diversion using the woven endobridge device (WEB; MicroVention, Aliso Viejo, CA, USA) for the treatment of intracranial aneurysms has demonstrated large scale safety and efficacy. However, limitations arise from its structural configuration, restricting its application to specific aneurysm sizes and shapes. Technique Overview We introduce the CUPCAKE technique, a combination of conventional coiling followed by WEB intrasaccular flow disruption in select cases of atypical aneurysms with technically challenging morphology not typically treatable by WEB alone. Materials and Methods A retrospective analysis of a prospectively-maintained dataset from three Australian neurovascular tertiary referral centers, identifying patients treated with the CUPCAKE technique between April 2018 and September 2023. Evaluation of patient and aneurysm characteristics, procedure parameters, complications, radiological and clinical outcomes at follow-up was performed. Results The CUPCAKE technique was used for the treatment of 22 intracranial aneurysms of total 169 treated with WEB. Overall successful immediate flow stagnation was observed in 95.5% ( n = 21) of aneurysms with no cases of perforation or intraoperative hemorrhage. Imaging confirmed thromboembolic complications occurred in two patients, one patient had persistent flow requiring re-treatment during initial admission. Follow-up imaging demonstrated 88.2% complete aneurysm conclusion with no delayed aneurysm expansion or rupture. Conclusion Synergistic use of conventional coiling with WEB intrasaccular flow disruption presents a viable solution for technically difficult aneurysm treatment. In our series, 13% of all patients treated with WEB received CUPCAKE treatment, resulting in high technical success and no increase in thromboembolic complications with the union of two methods.
Efficacy of the Optilume paclitaxel drug-coated balloon after urethroplasty: short-term results from a multicenter study
Authors: VanDyke Maia , Joshi Eshan , Ceballos Brian , Baumgarten Adam , Matz Ethan , Graham Kayla S. , McKibben Maxim J. , Imam Ahmad , Wiegand Lucas , Franzen Bryce , Hudak Steven 
Published: January 2025

Background: The Optilume® paclitaxel drug-coated balloon (DCB) is a relatively new-to-market alternative in the management of male anterior urethral stricture disease. The pivotal trial excluded patients with a history of urethroplasty, although these strictures may be amenable to endoscopic management. Therefore, we sought to assess the efficacy of the DCB in the management of recurrent strictures following urethroplasty. Methods: A retrospective, multi-institutional review of male patients undergoing DCB dilation from 1/1/2022 to 11/1/2023 by five surgeons at four institutions was performed. Patients were stratified by history of urethroplasty; demographics, stricture characteristics, and outcomes (surgical success, time to recurrence). Success was defined as freedom from re-intervention in patients with at least 3 months of follow-up. Results: Among the 122 cases assessed, 33 (27.0%) had previously undergone urethroplasty. Patients in the urethroplasty group were younger than those in the control group (51.6 vs 58.8 years, p = 0.022). The two groups were otherwise similar with regard to background characteristics and comorbidities. Patients in both groups had similar stricture characteristics with short bulbar strictures being the most common. When compared to the control group, those with a history of prior urethroplasty had a greater median number of interventions prior to DCB treatment (3 vs 1, p < 0.001). Postoperative cystoscopy was performed in 37 cases, with similar patency rates between groups ( p > 0.999). Early success rates were similarly high in both groups (80.0% post-urethroplasty vs 88.9% control, p = 0.338), although follow-up was limited to a median of 3.5 months in the urethroplasty group and 2.9 months in the control group ( p = 0.069). Conclusion: Despite a greater number of prior surgical interventions, patients with a history of urethroplasty achieve similarly high success rates after treatment with DCB compared to those without a history of urethroplasty.
The effect of polygenic risk score on PD risk and phenotype in LRRK2 G2019S and GBA1 carriers
Authors: Goldstein Orly , Shani Shachar , Gana-Weisz Mali , Elkoshi Nadav , Casey Fergal , Sun Yu H , Chandratre Khyati , Cedarbaum Jesse M , Blauwendraat Cornelis , Bar-Shira Anat , Thaler Avner , Gurevich Tanya , Mirelman Anat , Giladi Nir , Orr-Urtreger Avi , Alcalay Roy N 
Published: January 2025

Background While LRRK2 and GBA1 variants are associated with Parkinson's disease (PD), most carriers will not develop the disease. Objective To test if polygenic risk score (PRS) modifies disease risk and phenotypes in LRRK2 G2019S carriers, GBA1 carriers, and non-carriers (NC). Methods We genotyped 786 participants using Illumina's NeuroBooster-array (NBA) and sequenced the genome of 244, all of Ashkenazi ancestry (AJ), and calculated PRS to test its effects on clinically- and biologically-defined disease risk and phenotypes (n = 715). Among LRRK2 G2019S PD, we tested PRS association with α-synuclein seed-amplification-assay (n = 11). We used the PPMI and AMP-PD databases as validation cohorts. Results In clinically-defined PD, PRS significantly modified disease risk in GBA1 carriers and in NC ( p = 0.033 and p < 0.0001, respectively), and demonstrated a trend in LRRK2 G2019S carriers ( p = 0.054), with similar effect sizes (OR = 1.55, 1.62, and 1.49, respectively). PRS association with PD risk in LRRK2 was primarily driven by the rs7938782-A risk allele, replicated in AMP-PD (268 AJs LRRK2 G2019S carriers). PRS and age-at-onset were negatively correlated in NC ( p < 0.0001). NBA GBA1 genotype calls failed at GBA1 L483P and c.115 + 1G > A mutations. False negative call rate of 10.2% was observed for the imputed GBA1 N409S carriers. Conclusions PRS contributes to PD risk across different genotypes. The genetic and epigenetic role of rs7938782 in LRRK2 PD risk should be further explored. Future PRS models should be tailored to specific genotypes to better understand penetrance and phenotypes. Furthermore, models predicting PD defined biologically rather than clinically may further identify genetic risk factors for synucleinopathies.
Assessing static balance control improvement following cataract surgery using a smartphone
Authors: Azevedo Lorrana de Souza , Feitosa Newton Quintino , Santos Enzo Gabriel Rocha , Alvarez Márcio Augusto Moraes , Norat Lucciano Augusto Ximenes , Botelho Gabriel Izan Santos , Belgamo Anderson , Pinto Gustavo Henrique Lima , Santana Castro Ketlin Jaqueline , Callegari Bianca , Costa e Silva Anselmo de Athayde , Salomão Raílson Cruz , Cabral André dos Santos , Rosa Alexandre Antônio Marques , Souza Givago Silva 
Published: January 2025

Introduction Cataract remains a prevalent cause of visual impairment among the elderly, significantly increasing the risk of falls due to compromised visual function. Cataract removal surgery has been established as a means to enhance visual acuity and balance control. The advent of novel technologies, such as accelerometers integrated into smartphones, provides an opportunity to assess static balance control. We compared static balance measurements obtained from accelerometer built-in smartphones before and after cataract removal surgery. Methods Our sample comprised 29 individuals diagnosed with bilateral cataracts scheduled for cataract removal surgery. We evaluated participants’ visual acuity and recorded their body oscillations using the smartphone's embedded accelerometer during static balance maintenance, both with eyes open and closed, before and after surgery. We compared quantitative parameters of static balance evaluation at both time points. Results A significant improvement in visual acuity following cataract removal surgery was observed. Moreover, under open-eye conditions, all quantitative parameters of static balance evaluation exhibited significant improvement, with only one parameter showing improvement under closed-eye conditions. Conclusion Inertial sensors integrated into smartphones serve as practical tools for monitoring changes in static balance control resulting from cataracts, as well as for evaluating balance recovery after lens extraction surgery.
Use of Cervical Approach for Insertion of the Impella 5.5 Ventricular Assist Device (Abiomed) in Pediatric Patients: Cohort Study
Authors: Absi Mohammed , Gienapp Andrew J. , Buyukgoz Cihangir , Sathanandam Shyam , Boston Umar 
Published: January 2025

Background Impella 5.5 ventricular assist device (VAD) insertion is typically done via the axillary artery or directly through the aorta; however, an axillary artery must be ≥6 mm in diameter, which excludes many pediatric patients who do not meet this criterion. The innominate artery is a larger vessel that can better accommodate the Impella VAD in pediatric patients. Outcomes of this technique were compared with other pediatric patients undergoing the standard axillary artery cannulation. Methods The Heart Center at Le Bonheur Children's Hospital recently adopted the trans-innominate cervical approach for insertion of the Impella 5.5 VAD. We performed a retrospective cohort study comparing these cases to data collected from cases using an axillary approach found in the Advanced Cardiac Therapies Improving Outcomes Network database. Comparisons between preoperative characteristics, postoperative course, adverse events, anticoagulation, and clinical outcomes for these two groups were analyzed. Results Thirty-nine patients were implanted via the axillary approach; seven patients were implanted via the transinnominate cervical approach at our institution. Patients inserted via the trans-innominate approach had fewer days on the device (median, 8 [range, 3-24]), postimplant intensive care unit days (16 [3-24]), and hospital length of stay (14 [3-28]) compared with axillary insertion patients (12.5 [6.75-29.2], 58.5 [12.5-43.5], and 32 [19.7-83.5], respectively). Trans-innominate patients had fewer adverse events than axillary patients. Conclusions Trans-innominate cervical approach for insertion of the Impella 5.5 VAD is safe with low rates of adverse events in pediatric patients. As miniaturization of VAD therapy continues to evolve, this technique may provide greater application of these devices for even smaller children.
Structural reversal of disc cupping measured in Bruch’s membrane opening-based OCT morphometry after PRESERFLO microshunt implantation for open-angle glaucoma
Authors: Lüke Jan Niklas , Popp Constantin , Gietzelt Caroline , Steinberg Florian , Lüke Vincent , Lappa Alexandra , Dietlein Thomas , Enders Philip 
Published: January 2025

Abstract

Background/ Aims
To analyze the longitudinal change in Bruch’s membrane opening minimal rim width (BMO-MRW) and peripapillary retinal nerve fiber layer (pRNFL) thickness using optical coherence tomography (OCT) after implantation of a PRESERFLO® microshunt for surgical glaucoma management in adult glaucoma patients.

Methods
Retrospective data analysis of 59 eyes of 59 participants undergoing implantation of a PRESERFLO microshunt between 2019 and 2022 at a tertiary center for glaucoma management. Surgical management included primary temporary occlusion of the glaucoma shunt to prevent early hypotony. Pre- and post-operative OCT examinations of the optic nerve head (ONH) and intraocular pressure (IOP) were assessed. Longitudinal change in morphometric spectral domain OCT parameters of the ONH was correlated to change in IOP.

Results
BMO-MRW increased significantly between baseline (BL) and follow-up (FU) within the first three months after surgery (BL = 171.15 ± 66.80 μm; FU = 180.78 ± 70.394 μm; p = 0.034). For the same postoperative period, the mean preoperative IOP of 24.97 ± 7.22mmHg was lowered after surgery to 13.70 ± 5.09 mmHg. Eighteen months after surgery, there was no significant change in BMO-MRW compared to baseline (BL = 169.83 ± 52.69 μm; FU = 164.98 ± 55.85 μm; p = 0.271), while mean IOP was 13.08 ± 4.48 mmHg. A decrease in IOP correlated significantly with a change in BMO-MRW (r = 0.453, p < 0.05) three months after surgery. Peripapillary RNFL thickness was unchanged in follow-up after three months (p > 0.16) and significantly decreased in later follow-up (p = 0.009).

Conclusion
PRESERFLO® microshunt implantation with primary temporary occlusion leads to a significant transient increase in BMO-MRW. This phenomenon is also known as structural reversal of disc cupping (SRDC). The effect seems to be less pronounced and of shorter duration when compared to previous data after trabeculectomy with comparable pre- and postoperative IOP levels.