bluuebunny/crossref_metadata_2025_split huggingface dataset:
The urge to breed early: Similar responses to environmental conditions in short‐ and long‐distance migrants during spring migration
Authors: Rüppel Georg , Hüppop Ommo , Schmaljohann Heiko , Brust Vera 
Published: July 2023

AbstractBirds migrating different distances experience different temporal, energetic, physiological, and physical constraints throughout migration, which is reflected in their migration strategy. Consequently, we predict different behavioral decisions to similar environmental cues between short‐ and long‐distance migrants, which has been documented for autumn migration. Here, we focus on the question whether trade‐off decisions regarding departure, routing, and landing when alternating between migratory endurance flights and stopovers also differ during spring migration. As early arrivals at the breeding grounds should be ultimately favored regardless of migration distance, selection may favor more similar behavioral decisions in spring than in autumn. We radio‐tagged short‐ and long‐distance migratory songbirds at stopover sites along the German North Sea coast during spring and automatically tracked their migratory behavior using a large‐scale network of receiver stations. Once departed, birds could either cross the sea or detour along the coast. We corrected for spatially biased detection data, using a hierarchical multistate model to assess how birds respond to variation in environmental conditions in their day‐to‐day departure decisions and route selection. The day‐to‐day departure probability was higher in long‐distance migrants independently of the routing decision. Irrespective of migration distance, all species more likely departed under light winds and rainless conditions, while the influence of air pressure change and relative humidity was species‐specific. By accounting for detection probabilities, we estimated that about half of all individuals of each species crossed the sea but did not find differences between short‐ and long‐distance migrants. Offshore flights were more likely when winds blew offshore and began earlier within the night compared with onshore flights. Our results suggest that selection more similarly affects birds of different migration distances in spring than in autumn. These findings put the focus toward how ultimate mechanisms may shape departure and routing decisions differently between migration seasons.
Is personality and its association with energetics sex‐specific in yellow‐necked mice Apodemus flavicollis?
Authors: Strijker Beau N. , Iwińska Karolina , van der Zalm Bram , Zub Karol , Boratyński Jan S. 
Published: July 2023

AbstractFor the last two decades, behavioral physiologists aimed to explain a plausible covariation between energetics and personality, predicted by the “pace‐of‐life syndrome” (POLS) hypothesis. However, the results of these attempts are mixed with no definitive answer as to which of the two most acknowledged models “performance” or “allocation” predicts covariation between consistent among‐individual variation in metabolism and repeatable behavior (animal personality). The general conclusion is that the association between personality and energetics is rather context‐dependent. Life‐history, behavior, and physiology as well as its plausible covariation can be considered a part of sexual dimorphism. However, up to now, only a few studies demonstrated a sex‐specific correlation between metabolism and personality. Therefore, we tested the relationships between physiological and personality traits in a single population of yellow‐necked mice Apodemus flavicollis in the context of a plausible between‐sexes difference in this covariation. We hypothesized that the performance model will explain proactive behavior in males and the allocation model will apply to females. Behavioral traits were determined using the latency of risk‐taking and the open field tests, whereas the basal metabolic rates (BMR) was measured using indirect calorimetry. We have found a positive correlation between body mass‐adjusted BMR and repeatable proactive behavior in male mice, which can support the performance model. However, the females were rather consistent mainly in avoidance of risk‐taking that did not correlate with BMR, suggesting essential differences in personality between sexes. Most likely, the lack of convincing association between energetics and personality traits at the population level is caused by a different selection acting on the life histories of males and females. This may only result in weak support for the predictions of the POLS hypothesis when assuming that only a single model explaining the link between physiology and behavior operates in males and females. Thus, there is a need to consider the differences between sexes in behavioral studies to evaluate this hypothesis.
Diversification processes in Gerp's mouse lemur demonstrate the importance of rivers and altitude as biogeographic barriers in Madagascar's humid rainforests
Authors: van Elst Tobias , Schüßler Dominik , Rakotondravony Romule , Rovanirina Valisoa S. T. , Veillet Anne , Hohenlohe Paul A. , Ratsimbazafy Jonah H. , Rasoloarison Rodin M. , Rasoloharijaona Solofonirina , Randrianambinina Blanchard , Ramilison Miarisoa L. , Yoder Anne D. , Louis Edward E. , Radespiel Ute 
Published: July 2023

AbstractMadagascar exhibits exceptionally high levels of biodiversity and endemism. Models to explain the diversification and distribution of species in Madagascar stress the importance of historical variability in climate conditions which may have led to the formation of geographic barriers by changing water and habitat availability. The relative importance of these models for the diversification of the various forest‐adapted taxa of Madagascar has yet to be understood. Here, we reconstructed the phylogeographic history of Gerp's mouse lemur (Microcebus gerpi) to identify relevant mechanisms and drivers of diversification in Madagascar's humid rainforests. We used restriction site associated DNA (RAD) markers and applied population genomic and coalescent‐based techniques to estimate genetic diversity, population structure, gene flow and divergence times among M. gerpi populations and its two sister species M. jollyae and M. marohita. Genomic results were complemented with ecological niche models to better understand the relative barrier function of rivers and altitude. We show that M. gerpi diversified during the late Pleistocene. The inferred ecological niche, patterns of gene flow and genetic differentiation in M. gerpi suggest that the potential for rivers to act as biogeographic barriers depended on both size and elevation of headwaters. Populations on opposite sides of the largest river in the area with headwaters that extend far into the highlands show particularly high genetic differentiation, whereas rivers with lower elevation headwaters have weaker barrier functions, indicated by higher migration rates and admixture. We conclude that M. gerpi likely diversified through repeated cycles of dispersal punctuated by isolation to refugia as a result of paleoclimatic fluctuations during the Pleistocene. We argue that this diversification scenario serves as a model of diversification for other rainforest taxa that are similarly limited by geographic factors. In addition, we highlight conservation implications for this critically endangered species, which faces extreme habitat loss and fragmentation.
Emerging Anticancer Therapeutic Modalities Brought by Gold Complexes: Overview and Perspectives
Authors: Salmain Michèle , Bertrand Benoît 
Published: July 2023

AbstractThe medicinal chemistry of gold has experienced an exponential development since the 2000s. For long, the mechanisms of action of gold complexes have been limited to direct coordination of the gold ion or supramolecular interactions of the whole gold complex with biomolecules. In the recent years, other modes of action of gold‐based drug candidates have emerged. Herein, we review these new modalities, including photo‐induced cytotoxicity, selective protein modification and in cellulo catalysis.
C−H Functionalization of Aldehydes and Ketones with Transient Directing Groups: Recent Developments
Authors: Amistadi‐Revol Hugo , Liu Shanshan , Prévost Sébastien 
Published: July 2023

AbstractIn order to directly functionalize C−H bonds of complex molecules and, in particular, to control the regioselectivity of the reaction, a wide range of directing groups has been used. However, these directing groups need to be installed and removed for further applications, which may limit the use of C−H activation in synthesis. Concerning aldehydes and ketones, a transient directing group strategy has recently emerged to overcome this drawback. The addition of an additive, in general an amine, allowed the in situ formation of the real directing group to achieve C−H activation. This review presents the latest developments in the field over the period 2020–2023.
Evaluation of Toxicity and Genotoxicity of Concrete Cast with Steel Slags Using Higher Terrestrial Plants
Authors: Alias Carlotta , Piovani Giovanna , Benassi Laura , Abbà Alessandro , Sorlini Sabrina , Gelatti Umberto , Zerbini Ilaria , Feretti Donatella 
Published: July 2023

Abstract
The potential impact of concrete mixtures containing steel slag (SS) as a partial replacement of natural aggregates (NA) on the terrestrial ecosystem was assessed using a battery of plant-based bioassays. Leaching tests were conducted on four concrete mixtures and one mixture containing only NA (reference concrete). Leachates were tested for phytotoxicity using seeds of Lepidium sativum, Cucumis sativus, and Allium cepa. Emerging seedlings of L. sativum and A. cepa were used to assess DNA damage (comet test). The genotoxicity of the leachates was also analyzed with bulbs of A. cepa using the comet and chromosome aberration tests. None of the samples caused phytotoxic effects. On the contrary, almost all the samples supported the seedlings; and two leachates, one from the SS-containing concrete and the other from the reference concrete, promoted the growth of C. sativus and A. cepa. The DNA damage of L. sativum and A. cepa seedlings was significantly increased only by the reference concrete sample. In contrast, the DNA damage in A. cepa bulbs was significantly enhanced by the reference concrete but also by that of a concrete sample with SS. Furthermore, all leachates caused an increase in chromosomal aberrations in A. cepa bulbs. Despite some genotoxic effects of the concrete on plant cells, the partial replacement of SS does not seem to make the concrete more hazardous than the reference concrete, suggesting the potential use of SS as a reliable recycled material. Environ Toxicol Chem 2023;42:2193–2200. © 2023 The Authors. Environmental Toxicology and Chemistry published by Wiley Periodicals LLC on behalf of SETAC.
Chronic Exposure to Environmentally Relevant Concentrations of Imidacloprid Impact Survival and Ecologically Relevant Behaviors of Fathead Minnow Larvae
Authors: Jeninga Anya J. , Wallace Zion , Victoria Shayla , Harrahy Elisabeth , King-Heiden Tisha C. 
Published: July 2023

Abstract
Imidacloprid (IM) has emerged as a contaminant of concern in several areas within the United States due to its frequent detection in aquatic ecosystems and its pseudo-persistence, which pose potential risks to nontarget species. We evaluated the sublethal toxicity of IM to fathead minnow larvae following chronic exposure beginning just after fertilization. Our in silico analysis and in vivo bioassays suggest that IM has a low binding affinity for the vertebrate nicotinate acetylcholine receptor (nAChR), as expected. However, chronic exposure to ≥0.16 µg IM/L reduced survival by 10%, and exposure to ≥18 µg IM/L reduced survival by approximately 20%–40%. Surviving fish exposed to ≥0.16 µg IM/L showed reduced growth, altered embryonic motor activity, and premature hatching. Furthermore, a significant proportion of fish exposed to ≥0.16 µg IM/L were slower to respond to vibrational stimuli and slower to swim away, indicating that chronic exposure to IM has the potential to impair the ability of larvae to escape predation. The adverse health effects we observed indicate that chronic exposure to environmentally relevant concentrations of IM may elicit sublethal responses that culminate in a significant increase in mortality during early life stages, ultimately translating to reduced recruitment in wild fish populations. Environ Toxicol Chem 2023;42:2184–2192. © 2023 SETAC
Abstract
“Potential for chronic exposure to imidacloprid to adversely affect fish larvae.”
Quantifying phosphorus fertilizer distribution and the contribution of fertilizer and soil legacy phosphorus to phosphorus uptake by maize – A 32P‐labelling study
Authors: Zheng Dongfang , Yuan Huimin , Yang Guojiang , Feng Gu , Rengel Zed , Shen Jianbo 
Published: July 2023

AbstractThe availability of phosphorus (P) fertilizer applied to soil can diminish rapidly because of the complex soil P immobilization processes. However, the quantitative distribution of fertilizer P in the soil P fractions is not fully understood. Here, two experiments were conducted in a greenhouse using 32P‐labelled KH2PO4 to (i) quantify the distribution of P fertilizer in soil fractions, microorganisms and maize shoots grown in contrasting soils; (ii) characterize the effect of planting maize on soil P fractions and (iii) determine the amount of plant P derived from fertilizer vs. soil. Depending on the soil type, 74.1%–84.1% of the labelled P was retained in the soil, 11.4%–14.5% was found in maize shoots and 0.7%–4.5% was present in microorganisms. Distribution of applied P in the soil P fractions was dependent on soil type, with most P present as NaOH‐Pi and residual‐P in the Red soil, and as HCl‐P in the Fluvo‐aquic soil. Root‐mediated processes were involved in mobilisation of residual‐P in all three soils, with significant depletion of NaOH‐Pi in the Red soil, NaOH‐Pi and HCl‐P in the Black soil, and HCl‐P in the Fluvo‐aquic soil. The plant P derived from fertilizer and soil increased with increasing P addition rates in all three soils. In the soils with low‐P availability, fertilizer contributed more P to plants than soil, whereas in the initially high‐P soil, the opposite occurred. In conclusion, the partitioning of fertilizer P to various soil P fractions is dependent on the soil type, and the contribution of P derived from fertilizer to maize P uptake was related inversely to the soil legacy P.
Evaluation of the therapeutic effect of Descurainia sophia (L.) Webb ex Prantl seed extract on hyperthyroidism: A double‐blind placebo‐controlled pilot clinical trial
Authors: Farzameh Fatemeh , Azadbakht Mohammad , Kashi Zahra , Asgarirad Hossein , Salehifar Ebrahim , Mirzaee Fatemeh , Davoodi Ali , Amirkhanloo Shervin 
Published: July 2023

AbstractThe seeds of Descurainia sophia (L.) Webb ex Prantl contain goitrogenic glucosinolates, such as gluconapin (3‐butenyl glucosinolate). Because of the important role of iodine in the synthesis of thyroid hormones and the inhibitory activity of D. sophia on iodine uptake by the thyroid gland, this study aimed to determine the effects of D. sophia syrup on clinical and biochemical variables of thyrotoxicosis in hyperthyroid patients. In this randomized, double‐blind trial, 10 newly diagnosed hyperthyroid female patients were randomly assigned to treatment with (1) methimazole (MMI) plus D. sophia capsules (350 mg/d) or (2) MMI plus placebo capsules. The primary outcomes were clinical and biochemical manifestations of hyperthyroidism after 60 days. Serum levels of FT3 and FT4 significantly decreased (5.9 ± 2.5 vs. 9.4 ± 5.9 and 29.1 ± 3.1 vs. 31.77 ± 3.7, respectively) and the serum thyroid‐stimulating hormone (TSH) concentration significantly increased in the D. sophia group contrasted to the placebo group (4.7 ± 0.1 vs. 0.05 ± 0.02). Significant improvement in the thyrotoxicosis clinical symptoms was reported in the D. sophia group contrasted to the placebo group (p < .05). D. sophia can suppress plasma levels of FT3 and FT4 and may be useful as adjunctive therapy for hyperthyroidism.
Mango ginger (Curcuma amada Roxb.) may alleviate the effect of high‐fat diet/streptozotocin‐induced diabetes by activation of the GSK‐3β/Fyn/Nrf2 pathway
Authors: Yazici Emrah , Sahin Emre , Sahin Nurhan , Tuzcu Mehmet , Sahin Kazim , Orhan Cemal 
Published: July 2023

AbstractMango ginger (MG) exhibits antioxidant, anti‐inflammatory, and antihyperglycemic effects; however, the exact mechanism of action of MG extract in relation to its antidiabetic properties remains unclear. To investigate the potential antidiabetic effect of MG extract, we used a high‐fat diet (HFD)/low‐dose streptozotocin (STZ)‐induced type 2 diabetic rat model. A total of 28 male Wistar rats were randomly divided into four groups: (i) Control, (ii) MG (50 mg/kg/day of MG extract), (iii) HFD + STZ (40 mg/kg i.p.), and (iv) HFD + STZ + MG. Following a 12‐week administration of MG extract, significant reductions were observed in serum glucose, insulin, free fatty acid, cholesterol, and triglyceride levels in diabetic rats (p < .0001 for all). MG extract supplementation led to an increase in the total antioxidant capacity of the serum and a decrease in malondialdehyde (MDA) levels in both the serum and liver (p < .0001). Furthermore, hepatocellular fat accumulation was partially attenuated in the HFD + STZ + MG group. Notably, MG extract inhibited glycogen synthase kinase‐3β (GSK‐3β) in the liver (p < .01) and downregulated Fyn expression, resulting in elevated nuclear factor erythroid 2–related factor 2 (Nrf2) activity in the HFD + STZ + MG group compared to the HFD + STZ group (p < .05). The increased activity of Nrf2 in the HFD + STZ + MG group likely promoted the upregulation of heme oxygenase 1 (HO‐1) in the liver (p < .0001). In conclusion, MG extract may exert antidiabetic effects by augmenting the antioxidant defense system through the regulation of GSK‐3β/Fyn/Nrf2 in a rat model of type 2 diabetes.
Work with me or work for me: The effect of brand roles depends on implicit theories of self‐change
Authors: Rai Dipankar , Lin Chien‐Wei (Wilson) , Yang Chun‐Ming , Saint Clair Julian K. 
Published: July 2023

AbstractConsumer‐brand relationships are important predictors of consumption, but the psychology surrounding the different roles brands occupy within these relationships is not fully understood. Three experiments and one field study investigate how preferences for two of these brand roles, partner and servant, depend on consumers' implicit theories of self‐change. Counter to what prior literature might suggest, findings show that consumers who believe that self‐traits are relatively malleable (incremental theorists) and fixed (entity theorists) prefer partner and servant brands, respectively. Results demonstrate that a partner brand signals an equal effort by both the consumer and the brand, whereas a servant brand signals less effort by the consumer and more effort by the brand. The relatively greater consumer effort signals by partner (vs. servant) brands align with the effort beliefs associated with consumers' implicit theories, thereby mediating preferences. Findings are demonstrated across different product categories and samples (Taiwan and US). The focus on dyadic effort signals of brand roles in consumer‐brand relationships, and the resulting interactive effect with implicit theories, provide novel contributions to theory and practice.
Do single‐case experimental designs lead to randomised controlled trials of cognitive behavioural therapy interventions for adolescent anxiety and related disorders recommended in the National Institute of Clinical Excellence guidelines? A systematic review
Authors: Cawthorne Tom , Käll Anton , Bennett Sophie , Baker Elena , Cheung Emily , Shafran Roz 
Published: July 2023

AbstractBackgroundAlthough Cognitive Behavioural Therapy (CBT) is effective for 60% of adolescents with anxiety disorders, only 36% are in remission post‐intervention. This indicates that more effective treatments are needed which should be reflected in the NICE guidelines. We hypothesised that Single‐case experimental designs (SCEDs) may provide a framework for accelerating the development of novel interventions. The primary purpose of this review was to investigate whether SCEDs are currently followed by randomised controlled trials (RCTs) of CBT intervention for adolescent anxiety disorders named in the NICE guidelines. The secondary objective was to investigate whether using SCEDs prior to RCTs could be a helpful approach.MethodFor the primary search of SCEDs five databases were used (PsycINFO, PubMed, PsycArticles, Web of Science and ProQuest). Nineteen articles met eligibility criteria including a total of 107 participants. For the secondary search of RCTs named in the NICE guidelines for adolescent anxiety disorders 53 articles met inclusion criteria and were included in the systematic review.ResultsThe 19 SCED studies included in the review were conducted with participants with a diverse range of anxiety disorders and across a range of CBT formats. Two of the SCEDs were followed by RCTs, but neither of these were named in the NICE guidelines for anxiety disorders. All of the SCEDs identified were rated as low quality with none meeting the criteria for the highest or second highest quality rating. From the secondary searches, none of the RCTs named in the NICE guide were preceded by SCEDs.ConclusionsIt was concluded that currently SCEDs were not followed by RCTs of CBT interventions named in the NICE guidelines for adolescent anxiety disorders. However, it was suggested that SCEDs may provide an important framework for the development of more effective interventions for adolescents with anxiety.
How did the landscape of student belonging shift during COVID‐19?
Authors: Misra Shruti , Kardam Neha , VanAntwerp Jennifer , Wilson Denise 
Published: July 2023

AbstractBackgroundBelonging is a fundamental human motivation associated with a wide range of positive psychological, educational, social, and job outcomes. Frequent and predominantly conflict‐free interactions within a stable, relational framework of caring are required to facilitate belonging.PurposeThe goal of this study was to understand if and how emergency remote teaching (ERT) used during the COVID‐19 pandemic changed the ways in which instructional support and interactions were linked to belonging among engineering students.Methodology/ApproachThis study used survey data from a cross‐sectional dataset at a single large institution comprised of sophomore to senior‐level students (n = 1485) enrolled in engineering courses between 2016 and 2021. Hierarchical linear modeling (HLM) was used to study relationships among instructional support, instructor interactions, and belonging.Findings/ConclusionsHLM models of ERT and traditional learning differed dramatically. In traditional classroom learning, race, interactions with faculty and teaching assistants (TAs), and instructional support were important factors in belonging. In ERT, certain motivations to study engineering (altruism, desire to build things) had nuanced associations with belonging, while race and interactions with faculty and TAs became largely irrelevant. Most concerning, faculty interactions in traditional learning were negatively associated with belonging.ImplicationsRather than returning to pre‐pandemic traditional learning, a hybrid model that offers a more level playing field for marginalized students to find belonging in the classroom is recommended. In developing such models, faculty must take special care to avoid having a potentially negative impact on student belonging.