bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Affective Dimension Of Epistemic Injustice
Authors: Zembylas Michalinos 
Published: January 2023

AbstractThis essay focuses on the affective dimension of epistemic injustice — specifically, the affective harms and burdens of epistemic injustice on individuals and groups — and examines how pedagogy may help disrupt the affective injustice that epistemic injustice entails. This theorization facilitates the ability to recognize that affective wrongs are not separate from epistemic wrongs but are instead embedded in them. Here, Michalinos Zembylas brings recent philosophical inquiry on affective injustice into conversation with considerations of epistemic injustice in order to discuss how affect‐related conceptions of epistemic injustice help education scholars to illuminate the entanglement of the epistemic and the affective in the wrongs of testimonial, hermeneutical, and other forms of epistemic injustice. His analysis outlines how some theoretical concepts concerning “affective goods” — including affective freedoms, affective resources, and affective recognition — have important pedagogical implications for the role educators can play in rupturing epistemic‐affective injustices.
Rigidoporus microporus and the white root rot disease of rubber
Authors: Saidi Noor Baity , Al‐Obaidi Jameel R. , Fisol Ahmad Faiz bin Che 
Published: January 2023

AbstractRigidoporus microporus is an economically important plant pathogenic fungus causing particularly severe losses to the rubber industry worldwide. The pathogen is responsible for white root rot (WRR) disease, infecting the host roots via white fibrous mycelia, causing vascular disfunction, and visible symptoms including leaf discolouration and dieback in severely infected trees. The final stage of the disease is characterized by the appearance of basidiocarps at the tree collar. The development of WRR in rubber plantations is dependent on fungal diversity in the soil, pH, temperature, and cation levels. Several ‘‐omics’ approaches have been undertaken to understand how R. microporus functions with the objective, ultimately, to control WRR. Unfortunately, no resistant rubber clone has been identified to date. The disease is managed through physical and chemical methods that are laborious and negatively impact the environment, respectively. Recent developments in research on R. microporus shed light on potential sustainable routes to WRR disease control using beneficial microorganisms and natural compounds. This review discusses the characteristics of R. microporus isolates from different geographical origins, the pathogenicity and virulence mechanisms of the necrotrophic fungal pathogen, factors that influence the development of WRR, recent findings from the multi‐omics studies, and control methods that are available to combat this economically important pathogen.
Power politics and the expansion of US exports, 1879–1938
Authors: Tena‐Junguito Antonio , Restrepo‐Estrada Maria Isabel 
Published: January 2023

AbstractIn this article, we present quantitative evidence for the first time of the effect of US power politics on the expansion of its export market from the late nineteenth century to the eve of the Second World War. Like other empires, US imperial policy was expressed through annexation, gunboat policies, and asymmetrical trade agreements. We find that US exports to territories that became colonies or protectorates and those involved in other US military interventions grew more than three times faster between 1880–5 and 1934–8 than in the rest of the world. Our most relevant contribution to this discussion relies on a new geographically extensive database with information on bilateral trade flows, market size, trade costs, and variables that capture US political and military power. We first estimate a gravity equation to see the relationship between our power politics variables and US exports. Then, we present causal evidence of the role played by the colonies and protectorates in the expansion of US exports through an event study and the estimation of a generalized difference‐in‐differences model.
A retrospective non‐interventional study evaluating the pharmacokinetic interactions between cenobamate and clobazam
Authors: Elakkary Sally , Hagemann Anne , Klimpel Dennis , Bien Christian G. , Brandt Christian 
Published: January 2023

AbstractCenobamate is an antiseizure medication (ASM) approved for the treatment of partial‐onset seizures in adults. As both an inductor and an inhibitor of hepatic enzymes, cenobamate affects the metabolism of other ASMs, among which is clobazam. To our knowledge, the extent of interaction between cenobamate and clobazam and its clinical significance have not been studied yet. In this retrospective study we assessed serum concentrations of clobazam and N‐desmethylclobazam (NCLB)in five patients before and after co‐medication with cenobamate and calculated the percentage increase in concentration‐to‐dose ratio (CDR) of both. We were able to demonstrate that the addition of cenobamate resulted in an increase in serum concentration and consequently in CDR of NCLB in all patients. However this occurred in variable degrees: NCLB concentration showed an increase of 1208 μg/L (CDR145%) in one patient and between 1691 μ/L (CDR 819%) and 3995 μ/L (CDR 1852%) in the other four. This resulted in fatigue, which improved after dose reduction of CLB. Therefore, it is to be concluded that concomitant administration of cenobamate and clobazam can lead to a substantial increase in serum concentrations of NCLB. This can have a positive therapeutic effect on one hand; however, on the other hand, this can lead to unwanted fatigue.
HOXB7 induces STAT3‐mediated transformation and lung metastasis in immortalized mammary gland NMuMG cells
Authors: Azuma Kazushi , Sakamoto Mai , Katayama Shota , Matsui Atsuka , Nakamichi Kazuya , Goshima Naoki , Watanabe Shinya , Nakayama Jun , Semba Kentaro 
Published: January 2023

AbstractThe homeobox family genes are often dysregulated in various cancer types. Particularly HOXB7 amplification and overexpression correlate with poor prognosis in various cancer such as gastric, pancreatic, and lung cancers. Moreover, HOXB7 is known to contribute to cancer progression by promoting epithelial to mesenchymal transition, anticancer drug resistance, and angiogenesis. In this study, we show that HOXB7 is coamplified with ERBB2 in a subset of breast cancer patients and HOXB7 expression correlates with poor prognosis in HER2‐positive breast cancer patients. This clinical observation is supported by the following results—HOXB7 overexpression in an immortalized murine mammary gland epithelial cell line NMuMG induces cellular transformation in vitro, tumorigenesis, and lung metastasis through the activation of JAK‐STAT signaling.
Pre‐clinical evidence of a dual NADPH oxidase 1/4 inhibitor (setanaxib) in liver, kidney and lung fibrosis
Authors: Thannickal Victor J. , Jandeleit‐Dahm Karin , Szyndralewiez Cédric , Török Natalie J. 
Published: January 2023

AbstractFibrosis describes a dysregulated tissue remodelling response to persistent cellular injury and is the final pathological consequence of many chronic diseases that affect the liver, kidney and lung. Nicotinamide adenine dinucleotide phosphate (NADPH)‐oxidase (NOX) enzymes produce reactive oxygen species (ROS) as their primary function. ROS derived from NOX1 and NOX4 are key mediators of liver, kidney and lung fibrosis. Setanaxib (GKT137831) is a first‐in‐class, dual inhibitor of NOX1/4 and is the first NOX inhibitor to progress to clinical trial investigation. The anti‐fibrotic effects of setanaxib in liver, kidney and lung fibrosis are supported by multiple lines of pre‐clinical evidence. However, despite advances in our understanding, the precise roles of NOX1/4 in fibrosis require further investigation. Additionally, there is a translational gap between the pre‐clinical observations of setanaxib to date and the applicability of these to human patients within a clinical setting. This narrative review critically examines the role of NOX1/4 in liver, kidney and lung fibrosis, alongside the available evidence investigating setanaxib as a therapeutic agent in pre‐clinical models of disease. We discuss the potential clinical translatability of this pre‐clinical evidence, which provides rationale to explore NOX1/4 inhibition by setanaxib across various fibrotic pathologies in clinical trials involving human patients.
Effect of intestinal microbiota on liver disease and its related future prospection: From the perspective of intestinal barrier damage and microbial metabolites
Authors: Jiang Nan , Xiao Yuanyuan , Yuan Kefei , Wang Zhen 
Published: January 2023

AbstractLiver diseases contribute notably to the global concern of mortality and disease. Emerging evidence has demonstrated that intestinal microbiota can regulate intestinal barrier function and produce bioactive metabolites. Failure of any aspect of this barrier can result in the translocation of microbes into the blood and a sustained inflammatory response that promotes liver injury, fibrosis, and cirrhosis. Here, we review the mechanisms by that intestinal microbiota regulate the intestinal barrier. The multiple underlying mechanisms of intestinal microbiota in liver disease are elaborated in detail, emphasizing them as the bridge linking the liver with gut microbiota. Thus, we highlight the feasibility of targeting the gut‐liver axis for treating liver diseases.
Supply and Demand Effects of Bank Bailouts: Depositors Need Not Apply and Need Not Run
Authors: BERGER ALLEN N. , LAMERS MARTIEN , ROMAN RALUCA A. , SCHOORS KOEN 
Published: January 2023

AbstractWe address two key issues concerning bank bailout effects on depositor and bank behavior. The first is whether bailouts weaken or strengthen market discipline by depositors through deposit supplies. The second is if bailed‐out banks decrease or increase their deposit demands. These questions can only be adequately addressed by analyzing the effects of bailouts on both deposit quantities and prices. We do so for the Troubled Asset Relief Program (TARP) bailouts. Overall, we find that demand changes empirically dominate supply changes, and suggest significantly reduced deposit demand from bailouts. In some cases, however, supply changes dominate and indicate weakened market discipline.
Acute uterine inversion following an induced abortion
Authors: Swarray‐Deen Alim , Oduro Nana E. , Mensah Teresa A. , Boateng Alex K. , Ansing Caesar A. , Coleman Jerry 
Published: January 2023

AbstractAcute uterine inversion is a rare and potentially life‐threatening obstetric emergency. Its occurrence as a result of a mid‐trimester abortion is an even rarer consequence. We report a case of a 32‐year‐old woman who presented with complete acute uterine inversion and hemorrhagic shock following an incomplete medical abortion at 14 weeks of gestation. Our attempts at non‐operative reversal of the inversion failed. Therefore, we resorted to the manual replacement of the uterus via laparotomy without using surgical instruments or an incision in the cervical ring. The laparotomic manual replacement served as a successful alternative with minimal immediate or long‐term morbidity that may have resulted from trauma and scarring of the uterus.
Sparse hierarchical clustering based on Menopause Rating Scale severity of symptoms collected from perimenopausal and postmenopausal US women in a menopause tablet perceptual efficacy study
Authors: Kuesten Carla , Bi Jian , Zanetti Holiday Durham , Dang Jennifer 
Published: January 2023

AbstractThe sparse hierarchical clustering (SHC) method and the R package “sparcl” are used for consumer segmentation with 247 perimenopausal and postmenopausal US women. The data includes 11 menopause rating scale (MRS) attributes measuring severity of symptoms collected in the first week of a 12‐week extended use menopause tablet perceptual efficacy study. SHC is one of the advanced statistical clustering approaches for high‐dimensional data with potential noise variables. Sparse clustering is an important topic of the actively developing field of statistical learning with sparsity. An advantage of the SHC method is that it simultaneously finds the clusters of subjects and the important clustering variables. It allows clustering the data in low‐dimensional subspaces without dimension reduction of the data before clustering. The SHC method is particularly applicable to consumer segmentation based on high‐dimensional consumer data.Practical ApplicationsSparse hierarchical clustering (SHC) provides advantages in consumer segmentation based on high‐dimensional consumer data with potential noise variables. This advanced clustering method finds the relative importance of attributes in clustering, helping to identify homogeneous clusters and enhance understanding of how consumer responses/needs vary among clusters.
Differences in air displacement plethysmography, bioelectrical impedance analysis and dual‐energy X‐ray absorptiometry for estimating body composition in Chinese children and adolescents
Authors: Huang Yiwen , Wang Xi , Cheng Hong , Dong Hongbo , Shan Xinying , Zhao Xiaoyuan , Wang Xia , Xie Xianghui , Mi Jie 
Published: January 2023

AimThis study aimed to compare body composition (BC) measurements obtained by three widely used BC measuring methods, air displacement plethysmography (ADP), bioelectrical impedance analysis (BIA) and dual‐energy X‐ray absorptiometry (DXA), in Chinese children and adolescents by sex and different BMI categories.MethodsWe used three BC measuring methods to evaluate healthy Chinese children and adolescents aged 5–17 years with BMI categories ranging from underweight to obese. Fat mass (FM, kg), fat mass percentage (FMP, %), fat‐free mass (FFM, kg) and appendicular skeletal muscle mass (ASM, kg) were measured by DXA, BIA and ADP on the same day within 1 h.ResultsA total of 172 Chinese children and adolescents were included in this study. The agreements for FM, FFM and ASM estimated by the three methods were excellent or good at the population level (intraclass correlation coefficient > 0.850, P < 0.05). However, ADP or BIA estimated lower body fat content and higher FFM than DXA (P < 0.001 for all). Moreover, the precise estimates significantly varied across BMI categories. In addition, the limit of agreements was wide, and the differences might not be clinically acceptable at the individual level.ConclusionsBody fat and FFM obtained by the three commonly used methods were highly correlated, but systematically different and influenced by BMI. This study provided a basis for mutual reference of measurements between three widely used methods.
Hot hand or choking under pressure – Evidence from professional basketball
Authors: Jane Wen‐Jhan 
Published: January 2023

AbstractThis paper examines the existence of a hot hand and whether performing in front of a supportive audience creates a psychological pressure, which may impair performance. Using the task of free throwing in basketball competitions involving National Basketball Association (NBA) regular season and playoff games, I find strong evidence of a hot hand and a negative causal effect of the spectators on the probability of a successful shoot. The results support the hot hand fallacy and are in line with the hypothesis of choking under pressure when performing skill‐based tasks. Furthermore, contrary to what would be expected given the evidence in favor of a choking phenomenon, the effect of star players is insignificant. The hot hand effects for stars and non‐stars are the same in direction. Finally, efforts increase the performance, and the influence of hot hands and choking are not different between home and away shootings.
Organochlorine pesticide residues in water, sediments and Nile tilapia (Oreochromis niloticus) of Lake Nakuru, Kenya and implications for its fishery
Authors: Nantongo Mary Florence , Edebe Joseph , Otachi Elick O. , Kipkemboi Julius 
Published: January 2023

AbstractThe present study was conducted to assess the levels of selected organochlorine pesticide (OCP) residues in water, sediments and Nile tilapia, as well as the potential health risks to humans who consume the fish of Lake Nakuru. Nine composite water and nine sediment samples, as well as 30 fish specimens, were collected from five representative sampling sites within Lake Nakuru. The OCPs targeted in the present study included p,p′‐Dichlorodiphenyl dichloroethane (p,p′‐DDD), p,p′‐dichlorodiphenyldichloroethylene (p,p′‐DDE), p,p′‐dichlorodiphenyltrichloroethane (p,p′‐DDT), heptachlor, heptachlor epoxide, α endosulfan (1), β endosulfan (2), endosulfan sulphate, endrin, lindane, aldrin, dieldrin, methoxychlor and hexachlorocyclohexanes (alpha; beta; gamma; delta). Except for aldrin, all 16 OCPs targeted in the present study were detected. The OCP residue levels ranged from below detection limit (BDL) to 7.44 ± 0.66 μg/L, BDL to 6.39 ± 1.10 μg/kg ww and BDL to 319.74 ± 66.94 μg/kg ww in water, sediment and fish samples respectively. Some OCP concentrations exhibited significant differences across the sampling sites (p < .05). The residue level of endosulfan was above the European Union standard, whereas the target hazard quotient of heptachlor epoxide was above 1, therefore being unsafe for human consumption. The present study results indicate that most of organochlorine pesticides though banned in Kenya are still detected in the environment, posing potential long‐term health hazards to humans. Accordingly, environmental monitoring programme and mitigation strategies of reducing pollutant inputs into the lake is recommended, as well as an immediate ban on harvesting and consumption of fish from Lake Nakuru.
Framing the change and changing frames: Tensions in participative strategy development
Authors: Zimmermann Angelika , Kenter Jasper O. 
Published: January 2023

AbstractParticipative strategy development serves to integrate the interests and perspectives of multiple stakeholders involved in today's complex environmental challenges, aiming at a better‐informed strategy for tackling these challenges, increased stakeholder ownership, and more democratic decision making. Prior research has observed inherent tensions between the need for participative strategy to be open to stakeholders' input and the need for closure and guidance. We extend this reasoning using a framing perspective. Our evidence from the development of the England Peat Action Plan suggests that tensions can emerge between the necessary ambiguous initial framing of intended change and the persistence of stakeholders' different framings of this change as well as perceptions of lacking knowledge, guidance, and control. We argue that strategy openness can thereby impede stakeholders' willingness and ability to change and counteract the strategy's aim for major transformation. Interactive spaces help mitigate the tensions and facilitate stakeholders' willingness and ability for change.Related ArticlesBrant, Hanna K., Nathan Myers, and Katherine L. Runge. 2017. “Promotion, Protection, and Entrepreneurship: Stakeholder Participation and Policy Change in the 21st Century Cures Initiative.” Politics & Policy 45(3): 372–404. https://doi.org/10.1111/polp.12201.Bryson, John R., Michael Taylor, and Peter W. Daniels. 2008. “Commercializing ‘Creative’ Expertise: Business and Professional Services and Regional Economic Development in the West Midlands, United Kingdom.” Politics & Policy 36(2): 306–28. https://doi.org/10.1111/j.1747‐1346.2008.00107.x.Falkenström, Erica, and Stefan Svallfors. 2022. “The Knowledge–Management Complex: From Quality Registries to National Knowledge‐Driven Management in Swedish Health Care Governance.” Politics & Policy 50(5): 1053–66. https://doi.org/10.1111/polp.12497.
Minimal invasiveness in nonsurgical periodontal therapy
Authors: Ribeiro Fernanda V. , Mehta Jaimini J. , Monteiro Mabelle F. , Moore Jatinder , Casati Marcio Z. , Nibali Luigi 
Published: January 2023

AbstractPeriodontal treatment is quickly moving towards a philosophy consisting of a less invasive approach. In this context, minimally invasive nonsurgical therapy (MINST) is a promising option. This paper reviews the concepts behind minimal invasiveness in nonsurgical periodontology and reports the state‐of the art evidence for this topic. Instruments used and protocols suggested for these applications are introduced and discussed. The original papers reviewed show probing pocket depth (PPD) reductions and clinical attachment level (CAL) gains ranging from 2 to 4 mm between baseline and 6 months to 5 years posttreatment for intrabony defects and from 1.5 to 3 mm between baseline and 2‐6 months of follow‐up for full‐mouth results. These clinical outcomes are accompanied by statistically significant reductions in radiographic bone defect depth and increases in intrabony defect angles posttreatment. Wound healing mechanisms following MINST are presented, and clinical applications and directions for future research are suggested.
A Novel Data Assimilation-Based Real-Time State Estimation Method for Gas Influx Profiling During Riser Gas Events
Authors: Wei Chen , Tabjula Jagadeeshwar L. , Sharma Jyotsna , Chen Yuanhang 
Published: January 2023

AbstractRiser gas events during offshore drilling operations are hazardous and challenging to control. Therefore, knowledge of the gas influx sizes and distributions in a marine drilling riser is critical for the selection of riser gas handling methods and the estimation of risks of riser gas unloading. An extended Kalman filter-based data assimilation method is developed and evaluated for the real-time estimation of gas influx rates and void fraction distributions in a riser during riser gas handling. Full-scale experiments were conducted in this study for the evaluation of the proposed data assimilation method. An offshore well, which consists of a marine drilling riser and a wellbore below the subsea blowout preventer, was simulated by a 1572-m-deep experimental well. Real-time measurement data, including surface and downhole pressures, pump rates, and liquid outflow rates, were used to estimate the downhole gas influx rates using the Kalman filter. An online calibrated drift-flux model based on data assimilation is used to estimate the distributions of void fractions in the riser over time. The measurement data from a gas flowmeter and the distributed fiber-optic sensing were used to validate the estimation results, and satisfying performance was seen from the presented method. This study proposed a novel data assimilation-based state estimation method by maximizing the use of measurement data of different types from the available managed pressure drilling systems. This method enables the more accurate estimation and prediction of gas behaviors in a riser and helps to facilitate real-time decision-making during riser gas handling.