Immunogenicity of a 2-Dose Regimen of Moderna mRNA Beta/Omicron BA.1 Bivalent Variant Vaccine Boost in a Randomized Clinical Trial
Authors: Rouphael Nadine G , Branche Angela R , Diemert David J , Falsey Ann R , Losada Cecilia , Baden Lindsey R , Frey Sharon E , Whitaker Jennifer A , Little Susan J , Kamidani Satoshi , Walter Emmanuel B , Novak Richard M , Rupp Richard , Jackson Lisa A , Babu Tara M , Kottkamp Angelica C , Luetkemeyer Anne F , Immergluck Lilly C , Presti Rachel M , Bäcker Martín , Winokur Patricia L , Mahgoub Siham M , Goepfert Paul A , Fusco Dahlene N , Atmar Robert L , Posavad Christine M , Netzl Antonia , Smith Derek J , Telu Kalyani , Mu Jinjian , McQuarrie Lisa J , Makowski Mat , Makhene Mamodikoe K , Crandon Sonja , Montefiori David C , Roberts Paul C , Beigel John H ,   for the Coronavirus Variant Immunologic Landscape Trial (COVAIL) Study Team, Diemert David J , Malkin Elissa , Bethony Jeffrey M , Desrosiers Aimee , Siegel Marc , Branche Angela R , Falsey Ann R , Walsh Edward , Kingsley Patrick , Peasley Michael , Rouphael Nadine G , Losada Cecilia , Graciaa Daniel S , Samaha Hady , Rebolledo Paulina A , Wiley Zanthia , Baden Lindsey R , Sherman Amy C , Walsh Stephen R , Tong Alexandra , Rooks Rebecca , Frey Sharon E , Abate Getahun , Oikonomopoulou Zacharoula , Hoft Daniel F , Graham Irene , Whitaker Jennifer A , El Sahly Hana M , Keitel Wendy A , Healy C Mary , Atmar Robert L , Little Susan J , Martin Thomas C S , Carter Nicole , Hendrickx Steven , Anderson Evan J , Rostad Christina A , Kamidani Satoshi , Peters Etza , Walter Emmanuel B , Smith Michael J , Moody M Anthony , Schmader Kenneth E , Novak Richard M , Ladner Benjamin G , Wendrow Andrea , Herrick Jessica , Rupp Richard , Porterfield Laura , Jackson Lisa A , Dunstan Maya , Lau Rebecca , Carste Barbara , Babu Tara M , Wald Anna , Krause Taylor , Hauge Kirsten , Kottkamp Angelica C , Mulligan Mark J , Davis Tamia , Engelson Celia , Soma Vijaya , Luetkemeyer Anne F , Harris Chloe , Lopez Azquena Munoz , Immergluck Lilly C , Johnson Erica , Chan Austin , Presti Rachel M , O’Halloran Jane A , Thompson Ryley M , Bäcker Martín , Fleming Andrew B , Joseph Sajumon , Winokur Patricia L , Meier Jeffery , Stapleton Jack , Mahgoub Siham M , Maxwell Celia , Shami Sarah , Goepfert Paul A , Fusco Dahlene N , Drouin Arnaud C , Numbi Florice K , Lyke Kirsten E , Stephens David S , Neuzil Kathleen M , Farley Monica M , Marrazzo Jeanne , Young Sidnee Paschal , Lennox Jeffery , Atmar Robert L , McNeil Linda , Brown Elizabeth , Posavad Christine M , Meagher Megan A , McElrath Julie , Gale Mike , Abebe Kuleni , Makowski Mat , Hill Heather , Albert Jim , Baughman Holly , McQuarrie Lisa , Telu Kalyani , Mu Jinjian , McQuarrie Lisa J , Lewis Teri C , Giebeig Lisa A , Engel Theresa M , Griffith Caleb J , McDonald Wendi L , Burkey Alissa E , Hoopengardner Lisa B , Linton Jessica E , Gettinger Nikki L , Montefiori David C , Eaton Amanda , Smith Derek J , Netzl Antonia , Wilks Samuel H , Türeli Sina , Makhene Mamodikoe , Elsafy Mohamed , Pikaart-Tautges Rhonda , Arega Janice , Hoang Binh , Curtin Dan , Koo Hyung , Sindall Elisa , Crandon Sonja , DeGrace Marciela M , Post Diane J , Nayak Seema U , Roberts Paul C , Beigel John H 
Published: August 2023

Abstract
We compared the serologic responses of 1 dose versus 2 doses of a variant vaccine (Moderna mRNA-1273 Beta/Omicron BA.1 bivalent vaccine) in adults. A 2-dose boosting regimen with a variant vaccine did not increase the magnitude or the durability of the serological responses compared to a single variant vaccine boost.