bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hepatitis C prevalence and elimination planning in Pakistan, a bottom‐up approach accounting for provincial variation
Authors: Mooneyhan Ellen , Qureshi Huma , Mahmood Hassan , Tariq Muhammad , Maqbool Nabeel Ahmed , Anwar Masood , Aslam Mujahid , Azam Farooq , Blach Sarah , Khan Aamir Ghafoor , Hamid Saeed , Hussain Tanweer , Akhter Mohammad Khalil , Khan Ambreen , Khan Uzma , Khowaja Saira , Mahmood Khalid , Mazhar Samra , Nawaz Ahmad , Rose Ayub , Ghorezai Gul Sabeen Azam , Shah Sabeen , Sarwar Syeda Zahida , Razavi Homie 
Published: January 2023

AbstractIn Pakistan, substantial changes to hepatitis C virus (HCV) programming and treatment have occurred since the 2008 nationwide serosurvey estimated a 4.8% anti‐HCV prevalence. In the absence of an updated national study, this analysis uses provincial data to estimate a national prevalence and the interventions needed to achieve elimination. Using a Delphi process, epidemiologic HCV data for the four provinces of Pakistan (accounting for 97% of the population) were reviewed with 21 subject‐matter experts in Pakistan. Province‐level estimates were inputted into a mathematical model to estimate the national HCV disease burden in the absence of intervention (Base), and if the World Health Organization (WHO) elimination targets are achieved by 2030 (80% reduction in new infections, 90% diagnosis coverage, 80% treatment coverage, and 65% reduction in mortality: WHO Elimination). An estimated 9,746,000 (7,573,000–10,006,000) Pakistanis were living with viraemic HCV as of January 1, 2021; a viraemic prevalence of 4.3% (3.3–4.4). WHO Elimination would require an annual average of 18.8 million screens, 1.1 million treatments, and 46,700 new infections prevented anually between 2022 and 2030. Elimination would reduce total infections by 7,045,000, save 152,000 lives and prevent 104,000 incident cases of hepatocellular carcinoma from 2015 to 2030. Blood surveys, programmatic data, and expert panel input uncovered more HCV infections and lower treatment numbers in the provinces than estimated using national extrapolations, demonstrating the benefits of a bottom‐up approach. Screening and treatment must increase 20 times and 5 times, respectively, to curb the HCV epidemic in Pakistan and achieve elimination by 2030.
Vancomycin use for haemodialysis patients—Development of a new dosing protocol
Authors: Ho Enya , Gleeson Sarah , Roberts Sarah , Bondesio Kristen , Salmon Andrew 
Published: January 2023

AbstractAimTo develop a dosing and monitoring protocol to achieve therapeutic vancomycin levels on intermittent haemodialysis.MethodsWe identified 15 vancomycin treatment courses received by patients on intermittent haemodialysis at a district health board in Auckland, New Zealand. Demographic, biochemical and clinical parameters were gathered from their health records. We subsequently devised and implemented a new vancomycin protocol consisting of weight‐based loading dose, and subsequent dose titration according to same‐day measured pre‐dialysis levels. We then re‐audited 16 vancomycin treatment courses to assess the performance of the protocol.ResultsA significantly higher proportion of vancomycin levels were within the target range (15–20 mg/L) following the implementation of protocol, from 23% to 46% (p < .005). Additionally, a greater proportion of treatment courses had >50% of pre‐dialysis levels within the target range, rising from 13% to 56% (p < .01). In the pre‐protocol group, 19 out of 117 doses of vancomycin were withheld during treatment, compared to 1 out of 118 doses in the post‐protocol group. A total of 62% of total maintenance doses were administered in adherence to protocol. Length of hospital stay and number of positive blood cultures while on treatment were reduced.ConclusionsOur initial audit revealed deficiencies in our clinical practice in the absence of a local vancomycin protocol for patients receiving intermittent haemodialysis. Following the implementation of our novel protocol, there was an improvement in therapeutic levels and fewer doses were withheld. Our sample size was too small to allow for interpretation of clinical outcome data.
Risk factors for persistent fever in children with infectious mononucleosis
Authors: Zhou Jiwei , Cao Jie , Deng Boyin 
Published: January 2023

AbstractBackgroundFever is a common symptom in children with infectious mononucleosis (IM). However, the significance of the duration of a fever is poorly understood. This study aimed to analyze the risk factors for persistent fever in children with IM.MethodsPatients diagnosed with IM (aged <18 years; except those with concomitant hematological malignancies or tumor diseases) in a high‐volume academic hospital in 2019 were reviewed from a prospectively maintained database. Children with transient fever (≤7 days) were compared with those with persistent fever (>7 days). The risk factors for persistent fever in children with IM were examined using binary logistic regression. Furthermore, the predictive ability of these risk factors was assessed and presented using a receiver operating characteristic (ROC) curve.ResultsOf the 184 children included in this study, 131 (71.96%) belonged to the transient fever group and 53 (28.04%) belonged to the persistent fever group (median age: 49 and 64 months, respectively; p = 0.093). Statistical significance was observed in hepatomegaly, alanine aminotransferase level, blood triglyceride level, and blood Epstein–Barr virus polymerase chain reaction (EBV‐PCR) copy number (all p < 0.05). Binary logistic regression revealed that high blood triglyceride level was the risk factor for persistent fever in children with IM. High blood triglyceride level predicted persistent fever duration with an area under the ROC curve of 0.73 and an optimal cutoff value of 1.315 mmol/L.ConclusionHigh blood triglyceride level was the risk factor for persistent fever in children with IM. Thus, children with elevated levels of blood triglycerides need additional care. To diagnose IM, a blood EBV‐PCR is more useful than a throat‐swab EBV‐PCR.
Inoculum and disease dynamics of citrus greasy spot caused by Zasmidium citri‐griseum in sweet orange in Panama
Authors: Aguilera‐Cogley Vidal , Sedano Elena , Vicent Antonio 
Published: January 2023

AbstractCitrus greasy spot, caused by Zasmidium citri‐griseum, is a disease characterized by inducing premature defoliation and a reduction in yield in different citrus species. Greasy spot is the most prevalent fungal disease in sweet orange in Panama. Nevertheless, no epidemiological information is available. In this study, the dynamics of the defoliation, inoculum production, airborne inoculum and infection periods of Z. citri‐griseum and their associations with environmental conditions were determined in Panama. The period from December to April was characterized by greater defoliation of trees, with the greatest amount of leaf litter being produced in January and February. The number of days until total leaf decomposition (DLD) was related to the number of rainy days >1 mm (NRD), accumulated rainfall (AR) and average relative humidity (ARH). The number of ascospores released from leaf litter (ASCL) was related to DLD, NRD, AR and average temperature (AT). The greatest amounts of airborne ascospores (AASC) of Z. citri‐griseum occurred during April and May, when the rainy season begins in Panama. Similarly, the highest incidence (INC) of greasy spot in the trap plants coincided with the months of the greatest availability of airborne ascospores. However, infections were also recorded during other times of the year. The AASC or INC data were fitted to Bayesian models including meteorological variables and an autoregressive temporal component, the latter being the most influential. The results obtained in this study will allow the development of more efficient and sustainable fungicide programmes for greasy spot control in Panama.
“The chug is coming through!” “There's two chuggas!”: A longitudinal study of the social function of imitation in children's play with siblings and friends
Authors: Howe Nina , Paine Amy L. , Leach Jamie , Magazin Elena , Gilmore Victoria , DeHart Ganie 
Published: January 2023

AbstractImitation is argued to have an important affiliative function in social relationships. However, children's tendency to imitate different play partners during naturalistic play and associations with social understanding have been overlooked. We investigated the frequency and context of imitation in a longitudinal study of 65 focal children (T1: M age = 56.4 months, SD = 5.71) during play with their older or younger sibling and a friend in two separate play sessions. Children were observed again approximately 3 years later (T2: n = 46, M age = 94.6 months; SD = 6.6). We coded focal children's verbal and nonverbal imitation of their play partner, their partner's response to being imitated, the context in which imitation occurred (e.g., pretense), and the focal child's social understanding (i.e., mental state references). Verbal imitation occurred more often than nonverbal imitation and was used most often during the contexts of play negotiations and pretense. Although focal children's imitation of both their siblings and friends increased significantly over time, children imitated friends more than siblings at T1. All play partners responded positively (i.e., smiling, laughing) most often to being imitated. Associations between focal child imitation and mental state talk with friends at T2 approached significance. Our findings provide a deeper understanding of the nature of imitation during children's play interactions and support assertions that imitation is a process whereby children build affiliation, mutuality, and shared meanings in their relationships.
Developmental changes in mothers’ perception of knowledge, solicitation, and child disclosure during middle childhood
Authors: Desmarais Cloé , Poulin François 
Published: January 2023

AbstractParents can actively seek knowledge (solicitation) or receive information provided willingly by the child (disclosure). In adolescence, disclosure is the main source of parental knowledge, but its importance may take root earlier in the course of development. We examined: 1) the factor structure of an instrument adapted for middle childhood measuring maternal perception of knowledge, solicitation, and children's self‐disclosure; 2) changes in these dimensions over middle childhood; and 3) the respective contribution of solicitation and disclosure to parental knowledge. The mothers of 793 elementary school students (61.5% boys, 80.2% Canadian‐born) completed a questionnaire annually from Grades 1 to 4. Multilevel confirmatory factor analysis confirmed the instrument's structure at all time points. Growth curve analyses showed that mothers’ perception of knowledge slightly declined from Grades 1 to 4. With respect to mothers’ perceived parental solicitation and child disclosure, gender interactions emerged. Solicitation declined for girls but remained stable for boys, while disclosure declined for girls but increased for boys over time. In addition, mothers' perception ofdisclosure and solicitation are both main sources of maternal knowledge regardless of age and gender in middle childhood.
Knowledge, skills or social mobility? Citizens' perceptions of the purpose of education
Authors: Busemeyer Marius R. , Guillaud Elvire 
Published: January 2023

AbstractThis article explores individual views of the purpose of education. Most existing research focuses on attitudes and policy preferences; while these types of perceptions have so far been largely overlooked due to a lack of data. Our analysis of original survey data in eight Western European countries shows that personal socioeconomic factors and ideological predispositions shape these individual opinions. Individuals with higher levels of education and income are more likely to view education as aimed at expanding knowledge as goal by itself, and less likely to view it as a tool to promote intergenerational social mobility. Left‐leaning individuals are also more likely to regard education as a goal by itself, and less likely to view it as conferring useful labour market skills for the younger generation. Finally, we investigate the relationship between these different views and individual preferences for social policies. Our results show that the perception of education as promoting intergenerational mobility is strongly associated with support for passive transfers, while the perception of education as conferring marketable skills increases support for workfare policies. Social investment policies, because they are widely supported in the population, are not linked to specific views on education.
Soil fertility in indigenous swidden fields and fallows in northern Amazonia, Brazil
Authors: de Pinho Rachel Camargo , Pequeno Pedro Aurélio Costa Lima , Alfaia Sonia Sena , Barbosa Reinaldo Imbrozio , Lincoln Noa Kekuewa 
Published: January 2023

AbstractIn the northern Brazilian Amazon, indigenous peoples who inhabit the savannas of Roraima, plant their crop fields in frequently managed “forest islands” using a rotating “slash‐and‐burn” system. The system advocates long‐term sustainability, but population growth and threats to indigenous lands have led to shorter rotations and greater frequency of use of forest island areas. Our objective was to examine soil texture and fertility (0–20 cm in depth) in indigenous crop fields (roças) and fallow lands (capoeiras, secondary forests), generating recommendations that may help to optimize traditional soil management. Results indicated that roça sites are less acidic than capoeira sites, which was expected as ashes produced by burning are alkalizing, but acidity did not increase again after 8 months of cultivation, and pH was high in all sites (>6). The general increase in nutrients expected in roças compared with capoeiras did not occur. The expected decrease of soil fertility after first months of cultivation did not happen, nor the increase of soil fertility according to fallow length. Overall, soil texture proved to be the main determinant of fertility. The unexpected results suggest that the edaphic processes resulting from the traditional indigenous cultivations, practised for centuries or millennia in this region, likely contributed to the current stabilization of soil acidity and fertility. The stable moderate fertility and stable high pH observed in all sites are advantages for production in slash‐and‐burn systems in this region, and this is especially important for more pressured areas, where agroecological practices could improve soil use and management. Although not determinant for soil fertility recovery at the studied depth (0–20 cm), the fallow period (growth of capoeiras) is still important for recovery of environmental and social functions of forest islands.
Serum thymidine kinase 1 activity as a prognostic biomarker in dogs with chemotherapy‐treated diffuse large B‐cell lymphoma
Authors: Zaidi Bushra , Mukhopadhyay Abhijit , Ramos‐Vara José A. , Dhawan Deepika , Ruple Audrey , Childress Michael O. 
Published: January 2023

AbstractDiffuse large B‐cell lymphoma (DLBCL) is frequently treated with chemotherapy incorporating cyclophosphamide, doxorubicin, vincristine and prednisone (CHOP), which induces remission in 80% to 95% of cases. However, not all dogs derive meaningful benefit from CHOP, and prognostic factors for dogs with DLBCL are poorly defined. Serum thymidine kinase 1 (TK1) activity, a marker of tumour cell proliferation, has shown promising initial results as a prognostic biomarker in dogs with multicentric lymphomas. The purpose of this study was to determine if baseline serum TK1 activity is associated with clinical outcome in dogs with CHOP‐treated DLBCL. Baseline serum TK1 activity was measured in banked sera from 98 dogs with CHOP‐treated DLBCL using a commercially available ELISA kit. Data on other potential prognostic factors were abstracted retrospectively from electronic medical records. Multivariable statistical methods were used to identify associations between TK1 and other potential prognostic factors with progression‐free survival (PFS) and attainment of complete remission. TK1 activity at baseline was not associated with PFS (p = .299) or attainment of complete remission (p = .910) following CHOP chemotherapy. Of the other prognostic factors analysed, only purebred (vs. mixed breed) status (HR 8.81, 95% CI 1.68–46.30, p = .010), attainment of complete (vs. partial) remission (HR 0.09, 95% CI 0.02–0.49, p = .006), and baseline serum C‐reactive protein concentration (HR 1.19, 95% CI 1.07–1.32, p = .001) were independently associated with PFS. Based on these findings, baseline serum TK1 activity does not appear to be a useful prognostic biomarker in dogs with CHOP‐treated DLBCL.
Design Synthesis of Structural Systems as a Markov Decision Process Solved With Deep Reinforcement Learning
Authors: Ororbia Maximilian E. , Warn Gordon P. 
Published: January 2023

Abstract
Recently, it was demonstrated that the design synthesis of truss structures can be modeled as a Markov decision process (MDP) and solved using a tabular reinforcement learning method. In this setting, each state corresponds to a specific design configuration represented as a finite graph. However, when the structural design domain is relatively large, and depending on the constraints, the dimensionality of the state space becomes quite large rendering tabular reinforcement learning algorithms inefficient. Hence, in this study, the design synthesis MDP framework is significantly extended to solve structural design problems with large state spaces, by integrating deep reinforcement learning (DRL) into the general MDP framework. This is beneficial because with DRL, a deep neural network can be used to approximate the state-action value function, such that the network has much fewer parameters than the cardinality of the state space. This parameterization relies upon a problem relevant set of features and reward function. Thus, for this extended DRL design synthesis (DRLDS) framework, a compact set of features and a reward function are devised that are suitable for structural design problems where structural configurations are represented as finite graphs. Through the application of seven different structural design synthesis examples, the DRLDS framework is demonstrated to be capable of adeptly learning optimal policies that synthesize high, if not the highest, performing design solutions more frequently. The DRLDS framework does this with fewer finite element model evaluations than other considered alternative methods, further demonstrating the effectiveness of the developed set of features and reward function.
Influence of Matrix Material on Impact Properties of Chopped Carbon Fiber-Thermoplastic Composites Made Using FDM/FFF
Authors: Patterson Albert E. , Hasanov Seymur , Vajipeyajula Bhaskar 
Published: January 2023

Abstract
A major applications of thermoplastic additive manufacturing (typically completed using the fused deposition modeling or fused filament fabrication (FDM/FFF) process) is in the production of polymer matrix composites. Several different reinforcing materials have been proposed and studied, a common one of which is chopped carbon fibers (CCF). Most of the published research on the properties and effect of the CCF reinforcement has relied upon a poly(lactic acid) (PLA) matrix, as it has a low and stable melting temperature, low cost, and mixes readily with particulate or chopped reinforcing materials. For commercially available CCF filament for FDM/FFF, the typical fiber content is around 15–25% by volume, with the remainder being the thermoplastic matrix. To better explore the influence of the matrix material on the properties of these materials, this study compares the IZOD impact properties of standard CCF PLA with CCF-reinforced materials using polyamide/nylon (PA), polycarbonate (PC), acrylonitrile butadiene styrene (ABS), and polyethylene terephthalate glycol (PETG) matrices. All cases were printed at full (100%) density. For each material, samples of 5 mm thickness were tested in the Type A (notch in tension) and Type E (notch in compression) configurations. Two print orientations (flat and horizontal) and two raster angles (0–90° and ±45°) were considered for each combination. As required by ASTM D256, the tests were replicated five times each. The results are compared with the major literature for CCF reinforced PLA, as well as benchmark tests using injection molded samples and non-CCF PLA, PA, PC, ABS, and PETG processed by FDM/FFF.
Effects of Printing Parameters on Geometrical and Mechanical Properties of 3D-Printed High-Performance Thermoplastics, Toward the Digitalization of Power Transformers
Authors: Dutra Thiago Assis , Costa Catarina , Matos João R. , Oliveira Bruna F. , Oliveira Luís Miguel , Coutinho Cristiano Pereira 
Published: January 2023

Abstract
Traditionally, cellulosic materials have been applied in power transformers due to their good electrical insulation and oil absorption, although their hygroscopic characteristics consequently lead to time-consuming processes. Viewing to circumvent these limitations, the Additive Manufacturing of high-performance thermoplastics has been investigated as an alternative solution for solid insulation. In this context, the present work investigates the effect of process parameters on the geometrical and mechanical properties of 3D-printed Polyetheretherketone (PEEK) and Polyetherimide (PEI). To this end, the residual stresses and distortions are numerically computed considering different ranges of extrusion temperatures, printing speeds, and layer heights. Then, resulting elastic properties are predicted using the Asymptotic Homogenization technique. For that, two unit cells representing the microstructures found for the PEEK and PEI are adopted. From the obtained results, it was verified that lower layer heights and printing speeds, as well as higher extrusion temperatures, resulted in higher residual stresses. In contrast, higher layer heights, higher extrusion temperatures, and lower printing speeds resulted in higher distortions for both materials. In regards to the design of components, the obtained results provide useful data for both preliminary and critical analyses, potentially saving time and reducing waste of materials in future investigations involving 3D-printed high-performance thermoplastics.