bluuebunny/crossref_metadata_2025_split huggingface dataset:
Capabilities required of the conventional project delivery (CPD) approach in producing quality design documentation: the Ghanaian construction industry perspective
Authors: Agbaxode Peter Dodzi Kwasi , Saghatforoush Ehsan , Dlamini Sitsabo 
Published: September 2023

Purpose
The conventional project delivery (CPD) approach has been reported in the literature as the most widely used project delivery method in the construction industry globally compared to other delivery methods. However, researchers and practitioners have argued that the approach, specifically during the production of design documentation under the CPD, lacks certain capabilities that ensure quality and enhance project delivery. Therefore, this study aims to use the Ghanaian construction industry to identify the capabilities required of the CPD in practice, particularly during the production of design documentation.

Design/methodology/approach
The study design follows a pragmatist philosophy and uses mixed methods based on a deductive approach. Data collection involved a questionnaire survey, followed by semi-structured interviews. Quantitative data analysis used descriptive and inferential statistics, whereas qualitative data analysis used content analysis with the assistance of IBM SPSS and QSR Nvivo 12 Pro.

Findings
Findings indicate that there should be incentives for producing good design documentation quality; mandatory coordination of design documentation; improving collaboration among designers; and allowing contractors to make input during the design stage.

Practical implications
The results indicate the need for the identified capabilities to be introduced in the CPD approach to improve design documentation quality.

Originality/value
This study offers a significant insight into the specific capabilities that are required of the CPD approach in practice particularly, in the production of design documentation
The impact of brand value co-creation on perceived CSR authenticity and brand equity
Authors: Muniz Fernanda , Guzmán Francisco 
Published: September 2023

Purpose
In response to the rise of socially conscious consumers, brands have been taking a strategic approach to corporate social responsibility (CSR) to drive brand equity. Nevertheless, merely engaging in CSR is not enough to have a positive impact on the value consumers give to a brand. The success of a CSR program depends on its consumers’ perceived authenticity. Therefore, this study aims to investigate how the perception of CSR authenticity, and consequently brand equity, can be enhanced by leveraging brand value co-creation.

Design/methodology/approach
The study uses a mixed-method approach to test its hypotheses. Study 1 collects survey data from a national representative sample in the USA, which is analyzed using structural equation modeling. Study 2 collects experimental data from a public university’s research pool, also in the USA, which is analyzed using ANOVA and mediation analysis.

Findings
This study demonstrates that when consumers believe that a brand is co-creative – i.e. consumers are allowed to participate in the creation of value – they will likely perceive the brand’s CSR program as more authentic, which in turn will positively affect brand equity.

Originality/value
The findings of this study offer implications for academics and brand managers interested on how to effectively leverage CSR for brand building. Specifically, it demonstrates that embracing CSR alone may not be sufficient to enhance brand equity and that brand managers should consider leveraging co-creation to strengthen perceptions of CSR authenticity.
Politics, the Constitution and the Independence Movement in Scotland since Devolution
Authors: Petrie Malcolm 
Published: September 2023

AbstractThis article explores the course of Scottish politics since the establishment of the devolved parliament in 1999. It begins by considering the political roots of devolution before assessing the extent to which the electoral successes of the Scottish National Party (SNP) at the 2007 and 2011 devolved elections indicated a rise in support for Scottish independence. The focus then shifts to the political consequences of the 2014 independence referendum, in particular the relationship between the ‘Yes’ campaign and the SNP, as well as the changing social composition of the SNP's electoral support. The article concludes by examining the attempts of the SNP, and the wider independence movement, to secure a second independence referendum before reviewing recent political developments in Scotland.
The three constituencies of the state: why the state has lost unifying energy
Authors: King Desmond , Le Galès Patrick 
Published: September 2023

AbstractWe address resurgent populism by examining structural processes of state transformation in the UK, the US and France. Scholars stress the ‘unifying energy of the state’, a set of institutions and policies capable of limiting inequalities and defending legal regimes. One characteristic of modern Western statehood were packages of policies designed to integrate social groups and territories in part by ensuring common standards of provision and social citizenship across the nation state. This echoes James Scott's critical analysis of the modernist project of the state (1998). This ‘unifying energy’ had different origins including nationalist movements, combatting external influence or powers, war, and preparing citizens for the rigours of industrialization. Overcoming class differences and territorial differences (including cultural, social and economic differences) was a major source of mobilization to feed this ‘unifying energy of the state’ in France, Italy or Spain for instance. Political and cultural identities are related in significant part to respective nation states. We argue that this ‘unifying energy’ was an essential component of statehood in Europe and in the US. It is now largely lost. We explain why and the significance of its displacement.
Evaluating a health system‐wide opioid disposal intervention distributing home‐disposal bags
Authors: Huang Lyen C. , Bleicher Josh , Torre Michael , Johnson Jordan E. , Presson Angela , Millar Morgan M. , Gordon Adam J. , Brooke Benjamin S. , Kaphingst Kimberly A. , Harris Alex H. S. 
Published: September 2023

AbstractObjectiveTo evaluate a health system‐wide intervention distributing free home‐disposal bags to surgery patients prescribed opioids.Data Sources and Study SettingWe collected patient surveys and electronic medical record data at an academic health system.Study DesignWe conducted a prospective observational study. The bags were primarily distributed at pharmacies, though pharmacists delivered bags to some patients. The primary outcome was disposal of leftover opioids (effectiveness). Secondary outcomes were patient willingness to dispose and factors associated with disposal (effectiveness), recalling receipt of the bag (reach), and recalling receipt of bags and disposal over time (maintenance). We used a modified Poisson regression to evaluate the relative risk of disposal. Inverse probability of treatment weighting, based on propensity scores, was used to account for differences between survey responders and non‐responders and reduce nonresponse bias.Data Collection/Extraction MethodsFrom August 2020 to May 2021, we surveyed patients 2 weeks after discharge (allowing for home opioid use). Eligibility criteria were age ≥18, English being primary language, valid email address, hospitalization ≤30 days, discharge home, and an opioid prescription sent to a system pharmacy.Principal FindingsWe identified 5134 patients with 2174 completing the survey (response rate 42.3%). Among respondents, 1375 (63.8%) recalled receiving the disposal bag. Among 1075 respondents with leftover opioids, 284 (26.4%) disposed, 552 (51.3%) planned to dispose, 79 (7.4%) did not plan to dispose, 69 (6.4%) had undecided, and 91 (8.5%) had not considered disposal. Recalling receipt of the bag (incidence rate ratio [IRR] 1.25, 95% confidence interval [CI] 1.13–1.37) was positively associated with disposal. Patients who used opioids in the last year were less likely to dispose (IRR 0.82, 95% CI 0.73–0.93). Disposal rates remained stable over the study period while recalling receipt of bags trended up.ConclusionsA pragmatic implementation of a disposal intervention resulted in lower disposal rates than prior trials.
Amazon is coming to town: Sequential information revelation in the housing market
Authors: Chen Yifan , Wilkoff Sean , Yoshida Jiro 
Published: September 2023

AbstractThis study demonstrates that the housing market can incorporate information quickly instead of slowly over time, using Amazon's gradual revelation of its new headquarters locations in Virginia and New York. Spatial difference‐in‐differences analysis shows that housing prices near the Virginia headquarters exhibit premia months before the decision, while price premia for New York reach before the decision but disappear upon cancellation. The absence of significant effects on transaction volume, construction, or price premia for other finalist cities rules out the possibility of speculation. Overall, this study provides a counterpoint to the commonly held belief that the real estate market is always slow to respond to information about future demand shocks.
Deciphering the cellular heterogeneity of the insect brain with single‐cell RNA sequencing
Authors: Wang Xiaofei , Zhai Yifan , Zheng Hao 
Published: September 2023

AbstractInsects show highly complicated adaptive and sophisticated behaviors, including spatial orientation skills, learning ability, and social interaction. These behaviors are controlled by the insect brain, the central part of the nervous system. The tiny insect brain consists of millions of highly differentiated and interconnected cells forming a complex network. Decades of research has gone into an understanding of which parts of the insect brain possess particular behaviors, but exactly how they modulate these functional consequences needs to be clarified. Detailed description of the brain and behavior is required to decipher the complexity of cell types, as well as their connectivity and function. Single‐cell RNA‐sequencing (scRNA‐seq) has emerged recently as a breakthrough technology to understand the transcriptome at cellular resolution. With scRNA‐seq, it is possible to uncover the cellular heterogeneity of brain cells and elucidate their specific functions and state. In this review, we first review the basic structure of insect brains and the links to insect behaviors mainly focusing on learning and memory. Then the scRNA applications on insect brains are introduced by representative studies. Single‐cell RNA‐seq has allowed researchers to classify cell subpopulations within different insect brain regions, pinpoint single‐cell developmental trajectories, and identify gene regulatory networks. These developments empower the advances in neuroscience and shed light on the intricate problems in understanding insect brain functions and behaviors.
Natural human Bet v 1‐specific IgG antibodies recognize non‐conformational epitopes whereas IgE reacts with conformational epitopes
Authors: Brazhnikov Georgii , Smolnikov Evgenii , Litovkina Alla , Jiang Tianchi , Shatilov Artem , Tulaeva Inna , Tulaev Mikhail , Karaulov Alexander , Poroshina Alina , Zhernov Yury , Focke‐Tejkl Margarete , Weber Milena , Akinfenwa Oluwatoyin , Elisyutina Olga , Andreev Sergey , Shilovskiy Igor , Shershakova Nadezhda , Smirnov Valeriy , Fedenko Elena , Lepeshkova Tatiana Sergeevna , Beltyukov Evgeny Cronidovich , Naumova Veronika Victorovna , Kundi Michael , Khaitov Musa , Wiedermann Ursula , Valenta Rudolf , Campana Raffaela 
Published: September 2023

AbstractBackgroundThe nature of epitopes on Bet v 1 recognized by natural IgG antibodies of birch pollen allergic patients and birch pollen‐exposed but non‐sensitized subjects has not been studied in detail.ObjectiveTo investigate IgE and IgG recognition of Bet v 1 and to study the effects of natural Bet v 1‐specific IgG antibodies on IgE recognition of Bet v 1 and Bet v 1‐induced basophil activation.MethodsSera from birch pollen allergic patients (BPA, n = 76), allergic patients without birch pollen allergy (NBPA, n = 40) and non‐allergic individuals (NA, n = 48) were tested for IgE, IgG as well as IgG1 and IgG4 reactivity to folded recombinant Bet v 1, two unfolded recombinant Bet v 1 fragments comprising the N‐terminal (F1) and C‐terminal half of Bet v 1 (F2) and unfolded peptides spanning the corresponding sequences of Bet v 1 and the apple allergen Mal d 1 by ELISA or micro‐array analysis. The ability of Bet v 1‐specific serum antibodies from non‐allergic subjects to inhibit allergic patients IgE or IgG binding to rBet v 1 or to unfolded Bet v 1‐derivatives was assessed by competition ELISAs. Furthermore, the ability of serum antibodies from allergic and non‐allergic subjects to modulate Bet v 1‐induced basophil activation was investigated using rat basophilic leukaemia cells expressing the human FcεRI which had been loaded with IgE from BPA patients.ResultsIgE antibodies from BPA patients react almost exclusively with conformational epitopes whereas IgG, IgG1 and IgG4 antibodies from BPA, NBPA and NA subjects recognize mainly unfolded and sequential epitopes. IgG competition studies show that IgG specific for unfolded/sequential Bet v 1 epitopes is not inhibited by folded Bet v 1 and hence the latter seem to represent cryptic epitopes. IgG reactivity to Bet v 1 peptides did not correlate with IgG reactivity to the corresponding Mal d 1 peptides and therefore does not seem to be a result of primary sensitization to PR10 allergen‐containing food. Natural Bet v 1‐specific IgG antibodies inhibited IgE binding to Bet v 1 only poorly and could even enhance Bet v 1‐specific basophil activation.ConclusionIgE and IgG antibodies from BPA patients and birch pollen‐exposed non‐sensitized subjects recognize different epitopes. These findings explain why natural allergen‐specific IgG do not protect against allergic symptoms and suggest that allergen‐specific IgE and IgG have different clonal origin.
Balancing the ventricular outputs of pulsatile total artificial hearts
Authors: Gülcher Oskar J. , Vis Annemijn , Peirlinck Mathias , Kluin Jolanda 
Published: September 2023

AbstractBackgroundMaintaining balanced left and right cardiac outputs in a total artificial heart (TAH) is challenging due to the need for continuous adaptation to changing hemodynamic conditions. Proper balance in ventricular outputs of the left and right ventricles requires a preload‐sensitive response and mechanisms to address the higher volumetric efficiency of the right ventricle.MethodsThis review provides a comprehensive overview of various methods used to balance left and right ventricular outputs in pulsatile total artificial hearts, categorized based on their actuation mechanism.ResultsReported strategies include incorporating compliant materials and/or air cushions inside the ventricles, employing active control mechanisms to regulate ventricular filling state, and utilizing various shunts (such as hydraulic or intra‐atrial shunts). Furthermore, reducing right ventricular stroke volume compared to the left often serves to balance the ventricular outputs. Individually controlled actuation of both ventricles in a pulsatile TAH seems to be the simplest and most effective way to achieve proper preload sensitivity and left–right output balance. Pneumatically actuated TAHs have the advantage to respond passively to preload changes.ConclusionTherefore, a pneumatic TAH that comprises two individually actuated ventricles appears to be a more desirable option—both in terms of simplicity and efficacy—to respond to changing hemodynamic conditions.
Ocular and systemic associations and heritability of retinal arterial wall‐to‐lumen ratios in a twin cohort
Authors: Carstensen Christopher Voigt , Bjerager Jakob , Belmouhand Mohamed , Eckmann‐Hansen Christina , Rothenbuehler Simon P. , Dabbah Sami , Dalgård Christine , Laigaard Poul , Larsen Michael 
Published: September 2023

AbstractPurposeTo investigate ocular and systemic factors associated with the retinal arterial wall‐to‐lumen ratio (WLR) and to determine the relative contribution of genetic and environmental variation to WLR in healthy adults.MethodsThis cross‐sectional twin study included 78 monozygotic and 67 dizygotic same‐sex twin pairs aged 58.4 ± 9.8 (mean ± SD) years. Lumen diameter (LD) and outer diameter (OD) of a superotemporal retinal artery were measured using adaptive optics fundus photography, and the WLR was calculated. Linear mixed model regression analysis of associations with WLR comprised the descriptive variables ocular axial length (AL), intraocular pressure (IOP), height, weight, body mass index (BMI), smoking, blood pressure, high density (HDL), low density (LDL) and very low density (VLDL) lipoproteins, total cholesterol and triglycerides. The relative influence of genes and environment on WLR was calculated through polygenetic modelling.ResultsIncreasing age and arterial blood pressure were associated with a higher WLR, while increasing retinal artery OD and ocular AL were associated with a lower WLR. Sex, smoking status, BMI, IOP, cholesterol levels or triglycerides had no detectable impact on the WLR. Broad‐sense heritability of WLR was 21% (95% CI: 1–41%), while environmental factors accounted for the remaining 79% of the interindividual variance (95% CI: 59–99%).ConclusionRetinal artery wall thickness was closely linked to increasing age and higher arterial blood pressure, the latter being mediated by the environment over genes.
Visual function in Norwegian children aged 5–13 years with prenatal exposure to opioid maintenance therapy: A case–control study
Authors: Aslaksen Anne Kathinka , Vikesdal Gro Horgen , Voie Marit Torbergsen , Rowlands Megan , Skranes Jon , Haugen Olav H. 
Published: September 2023

AbstractPurposeTo assess various aspects of visual function in school children prenatally exposed to opioid maintenance therapy (OMT) and to explore possible outcome differences between prenatal methadone and buprenorphine exposure.MethodsIn a cross‐sectional case–control study, 63 children aged 5–13 years with prenatal OMT exposure were compared with 63 age‐ and gender‐matched, non‐exposed controls regarding important visual parameters, such as visual acuity, orthoptic status, refractive state, colour vision, and visual field.ResultsThe OMT‐exposed children had significantly poorer visual acuity, both for the best eye, the worst eye and binocularly. Two children had mild visual impairment. Manifest strabismus was more frequent in the OMT group, 30%, vs. 4.8% in the control group. The most frequent types of strabismus were accommodative esotropia and intermittent exotropia. Manifest nystagmus was present in 10 (16%) of the exposed children compared to one among the non‐exposed children. The accommodative amplitude was decreased in the OMT group compared to the controls. After adjusting for polydrug exposure and SGA (small‐for‐gestational‐age), the between‐group differences in visual acuity, strabismus, and nystagmus remained. The methadone‐exposed children had poorer visual acuity, increased frequency of strabismus and a higher percentage of nystagmus, hypermetropia and astigmatism compared to the buprenorphine‐exposed children.ConclusionsSchool‐age children exposed to methadone or buprenorphine in utero had a higher prevalence of strabismus and nystagmus, and a lower visual acuity and accommodation amplitude. Buprenorphine exposure was associated with more favourable results than methadone exposure on most visual outcome measures and should be the preferred substance in OMT.
Letter: Causal relationship between aspirin and the risk of hepatocellular carcinoma remains unproven
Authors: Wu Jia‐Lin , Luo Jun‐Yang , Deng Xin‐Yi , Jiang Zai‐Bo 
Published: September 2023

LINKED CONTENTThis article is linked to Lee et al paper. To view this article, visit https://doi.org/10.1111/apt.17643
Regression-Based Multiple Treatment Effect Estimation under Covariate-Adaptive Randomization
Authors: Gu Yujia , Liu Hanzhong , Ma Wei 
Published: September 2023

Abstract
Covariate-adaptive randomization methods are widely used in clinical trials to balance baseline covariates. Recent studies have shown the validity of using regression-based estimators for treatment effects without imposing functional form requirements on the true data generation model. These studies have had limitations in certain scenarios; for example, in the case of multiple treatment groups, these studies did not consider additional covariates or assumed that the allocation ratios were the same across strata. To address these limitations, we develop a stratum-common estimator and a stratum-specific estimator under multiple treatments. We derive the asymptotic behaviors of these estimators and propose consistent nonparametric estimators for asymptotic variances. To determine their efficiency, we compare the estimators with the stratified difference-in-means estimator as the benchmark. We find that the stratum-specific estimator guarantees efficiency gains, regardless of whether the allocation ratios across strata are the same or different. Our conclusions were also validated by simulation studies and a real clinical trial example.
Exploring examinees' responses to constructed response items with a supervised topic model
Authors: Kim Seohyun , Lu Zhenqiu , Cohen Allan S. 
Published: September 2023

AbstractTextual data are increasingly common in test data as many assessments include constructed response (CR) items as indicators of participants' understanding. The development of techniques based on natural language processing has made it possible for researchers to rapidly analyse large sets of textual data. One family of statistical techniques for this purpose are probabilistic topic models. Topic modelling is a technique for detecting the latent topic structure in a collection of documents and has been widely used to analyse texts in a variety of areas. The detected topics can reveal primary themes in the documents, and the relative use of topics can be useful in investigating the variability of the documents. Supervised latent Dirichlet allocation (SLDA) is a popular topic model in that family that jointly models textual data and paired responses such as could occur with participants' textual answers to CR items and their rubric‐based scores. SLDA has an assumption of a homogeneous relationship between textual data and paired responses across all documents. This approach, while useful for some purposes, may not be satisfied for situations in which a population has subgroups that have different relationships. In this study, we introduce a new supervised topic model that incorporates finite‐mixture modelling into the SLDA. This new model can detect latent groups of participants that have different relationships between their textual responses and associated scores. The model is illustrated with an example from an analysis of a set of textual responses and paired scores from a middle grades assessment of science inquiry knowledge. A simulation study is presented to investigate the performance of the proposed model under practical testing conditions.