bluuebunny/crossref_metadata_2025_split huggingface dataset:
MR textural features (RADIOMICS) for predicting response to treatment in patients with intracranial tuberculoma: A retrospective cross-sectional study
Authors: Muhammad Awais , Khan Shahmeer , Muhammad Wasay , Muhammad Azeemuddin , Shoukat Ayesha , Khan Hafsa 
Published: March 2023

Background and objective:
MR based radiomics can potentially response to treatment in intracranial tuberculoma, but very scarce literature is available in this regard. The purpose of this study was to determine whether MR based radiomic features can be used to predict response to antituberculosis (AT) treatment.
Methods:
Data of patients with intracranial tuberculomas who underwent MR imaging and AT treatment at our institution during the last 10 years was analyzed. In each case follow-up imaging performed at 6 months post initiation of treatment was reviewed to establish response to treatment. The textural analysis was performed by two consultant neuroradiologists, using open-source software (Lifex) with FLAIR coronal image after contrast administration from pretreatment MRI study radiomic analysis.
Results:
Twenty-four patients with mean age 33.8 years were included in the study. Sixteen patients were in the treatment responsive group while eight patients were in the treatment resistant group. Thirty-eight radiomic parameters were extracted for each patient. There was a significant difference in three out of 38 parameters (histogram skewness, GLCM correlation and NGLDM Coarseness) in patients amongst the two groups. Logistic regression model was developed using these parameters which accurately predicted 83.3% of the cases according to the response to the AT treatment (χ2=11.517, p=0.003). ROC curve analysis was performed using histogram skewness which showed acceptable discrimination (p=0.037 and 95% CI =0.577-0.954) for predicting the response to treatment.
Conclusion:
MR textural parameters (histogram skewness, GLCM correlation and NGLDM Coarseness) may be used as imaging biomarkers to predict response to treatment in patients with intracranial tuberculoma.
Anti-NMDA Receptor Encephalitis presenting with severe episodic hypertension: a case report
Authors: Arshad Tehreem , Hussain Musarrat , Yousafzai Abdul Wahab , Ahmad Arsalan 
Published: March 2023

Anti-N-methyl-D-aspartate receptor (Anti-NMDAR) encephalitis is one of the most commonly emerging autoimmune encephalitis in children and young adults in recent years. Clinical manifestations range from prodromal symptoms to seizures, movement disorder, psychiatric manifestations, cognitive/speech impairment, and autonomic dysfunction. Our case presented with initial symptoms of severe episodic hypertension, sweating, agitation, and tachycardia. She received early care for pheochromocytoma and panic disorder in Qatar, but there was no relief. Three weeks later, she presented in our emergency room with seizures, cognitive/speech impairment, and orofacial dyskinesia. Electroencephalography EEG revealed right hemispheric delta activity and cerebrospinal fluid CSF anti-NMDA Receptor IgG was positive. Magnetic resonance imaging MRI brain and CSF studies were normal. She was treated symptomatically for hypertension and psychiatric manifestations. She received high dosage pulse intravenous methylprednisolone, followed by intravenous immunoglobulin, which significantly alleviated her cognitive, neuropsychiatric, and autonomic features. Severe Hypertension is an uncommon presentation of Anti- NMDAR encephalitis. Early recognition and prompt management improves prognosis and long term sequelae.
Pediatric stroke: a review
Authors: Sultan Tipu 
Published: March 2023

Background & Objectives:
Pediatric stroke is a focal neurological deficit lasting more than 24 hours because of stenosis, occlusion or rupture of cerebral blood vessels. Variable etiological factors are involved ranging from cardiac, haematological, infectious, immune mediated to arteriopathies which is emerging as most important cause of arterial ischemic stroke in children. In this review article we will discuss paediatric stroke with its epidemiology, etiological factors in particular arteriopathies, diagnostic modalities, management protocols and outcome.
Methods:
We searched stroke in Pubmed and found 15315 articles, narrowed down to stroke in children (3814) and selected 45 articles for review.
Review:
Stroke in children is defined as a focal neurological deficit that persists for more than 24 hours and is caused by stenosis, occlusion or rupture of cerebral blood vessels. Stroke may be arterial, venous or because of occlusion of venous sinuses. Arterial strokes may be ischemic, haemorrhagic or ischemic-haemorrhagic.
About half of strokes in children are of arterial ischemic strokes in contrast to adults where about 80-85% strokes are of arterial ischemic strokes. Stroke in children is comparable to brain tumors and is one of top ten common causes of death in children.
Arterial ischemic stroke in children has significant risk of mortality and morbidity leading to functional disability of patient along with financial burden over family and society. In one study it was estimated that 10-25% of children with stroke die, 25% have recurrence and about 66% of children have neurological deficit after recovery from acute illness or have future epilepsy, behaviour disorder or learning disabilities.
Early recognition and prompt treatment of paediatric stroke can reduce mortality, morbidity and in return can reduce both social and financial burden over society.
Conclusion:
In this review article we will discuss paediatric strokes, epidemiology, risk factors, differential diagnosis, investigations, management protocols, preventive measures and outcome.
Clinical spectrum, risk factors and electrophysiologic aspect of radial nerve injury
Authors: Kanwal Arfah , Safia Bano  , Ullah Ubaid , Ahsan Numan  
Published: March 2023

Background and objective:
Radial nerve is injured due to a variety of reasons. The objective of this study was to determine the clinical spectrum, risk factors and electrophysiologic aspect of radial nerve injury presenting to a tertiary care hospital in Lahore.
Methods:
This descriptive prospective cross-sectional study was conducted at department of Neurology, Mayo hospital Lahore from July 2022 to December 2022 and comprised patients with isolated radial nerve injury on the basis of history and clinical examination regardless of their gender, above 15 years of age. NCS/EMG was done on a Japanese machine Nihon Kohden by an expert as per recommended protocol for electrodiagnostic evaluation of a suspected radial nerve injury and interpreted by consultant neurologist.
Results:
Of 75 patients, 52(69.3%) were males and 23(30.7%) were females. The most common etiology turned out to be misplaced intramuscular injection in 45(60%) of the patients. The site of lesion in most cases was in the spiral groove in 36 (40%) of the patient. Most of the patients i.e. 71(94.7%) had a wrist drop. Evidence of reinnervation was present in 30(40%) of patients.
Conclusion:
Most cases of radial nerve injury presented with a wrist drop in which the commonest etiology was misplaced intramuscular injection. The site of lesion in most cases turned out to at the level of spiral groove, and the nature of lesion was primarily axonal loss followed by secondary demyelination.
Effects of sub maximal aerobic exercise training versus flexibility exercises among young – polycystic ovarian syndrome
Authors: Prabha Sathya , Theras Sheirly Maria L. , Suresh Aswathi 
Published: March 2023

Background. Women of reproductive age suffer from an endocrine disorder called Polycystic Ovarian Syndromes (PCOS). It is basically related to metabolic disorders along with reproductive dysfunction. About 50-70% of women having PCOS suffer from Insulin Resistance (IR) which causes metabolic syndrome, dyslipidemia, hypertension, along with intolerance of glucose. Another harmful effect that occurred by PCOS is Hyperinsulinemia. Aim. This research is performed to contrast the effects of Sub Maximal Aerobic training (AE) Training with the Flexibility Exercises amongst Young – PCOS Population. Methods-24 PCOS diagnosed women were chosen. Centred on convenience sampling ‘12’ were on the AE group and the remaining 10 were on the flexibility group. Before and the end of the study, ‘22’ samples were screened with the homeostasis models assessment (HOMA) (Insulin), Ferriman-gallwey score, along with BMI. 3-5 times per week, AE of running or jogging was rendered to one group and flexibility exercises were rendered to the other group for 8 weeks and also audio-visual material used for reference. Results and conclusion. In the AE group, a small variation in the Insulin Resistance (IR) (p value = 0.0435) can well be seen as of the outcomes' comparison. There is a considerable post-test difference in betwixt groups of HOMA-IR. Thus, to improve insulin sensitivity resistance, PA is recommended among the PCOS population.
Một số cập nhật trong chẩn đoán viêm nội tâm mạc nhiễm khuẩn
Authors: PGS.TS.Hồ Huỳnh Quang Trí -  
Published: March 2023

MỞ ĐẦU
Năm 1885, GS. William Osler, một trong những người đặt nền tảng cho y học hiện đại, đã phát biểu như sau: “Ít có bệnh nào về mặt chẩn đoán gây nhiều khó khăn như viêm nội tâm mạc nhiễm khuẩn (VNTMNK), những khó khăn mà trong nhiều trường hợp là không thể khắc phục được. Nhiều thầy thuốc giỏi không sợ mất uy tín khi nhìn nhận rằng ở một nửa trong số bệnh nhân VNTMNK mà họ đã khám, chẩn đoán chỉ được xác định sau khi bệnh nhân chết”. Câu nói này phản ánh những khó khăn lớn trong việc chẩn đoán VNTMNK ở thời điểm đó. Hiện nay y học đã đạt rất nhiều tiến bộ, tuy nhiên chẩn đoán VNTMNK trong nhiều trường hợp cũng vẫn còn là một thách thức đối với thầy thuốc. Kể từ khi được công bố năm 2000, tiêu chuẩn Duke cải biên đã được các hội chuyên khoa khuyến cáo dùng để chẩn đoán VNTMNK (bảng 1) [1]. Dù được công nhận là bộ tiêu chuẩn tốt nhất từ trước đến nay để chẩn đoán VNTMNK, tiêu chuẩn Duke cải biên cũng chỉ có độ nhạy 70-79% [2,3]. Độ nhạy không cao này có liên quan với một số yếu tố, trong đó phải kể đến tỷ lệ cấy máu âm tính tương đối cao và những hạn chế của siêu âm tim thông thường. Trong thời gian gần đây đã có nhiều cải tiến quan trọng trong các kỹ thuật chẩn đoán hình ảnh tim mạch và vi sinh được ứng dụng vào việc xác định chẩn đoán VNTMNK cũng như xác định vi khuẩn gây bệnh.
Đánh giá hiệu quả kỹ thuật Crush tối thiểu trong can thiệp tổn thương chia đôi động mạch vành
Authors: Hồ Văn Phước  , Huỳnh Hữu Năm  , Nguyễn Trần An  , Lê Ngọc Tuấn Anh  
Published: March 2023

Mục tiêu: Đánh giá hiệu quả của kỹ thuật Crush tối thiểu trong can thiệp tổn thương chia đôi động mạch vành.
Đối tượng và phương pháp nghiên cứu: bao gồm 32 bệnh nhân, chẩn đoán tổn thương vị trí chia đôi động mạch vành, được can thiệp bằng kỹ thuật Crush tối thiểu tại Khoa Tim mạch can thiệp – Bệnh viện Đà Nẵng, thời gian từ tháng 3/2020 - 9/2020. Thành công về mặt kỹ thuật được định nghĩa khi thực hiện được tất cả các bước của kỹ thuật Crush tối thiểu và không có biến chứng. Tái khám sau 2 tháng, đánh giá biến cố tim mạch chính (tử vong do mọi nguyên nhân, nhồi máu cơ tim, cần tái thông lại động mạch vành, đột quỵ và nhập viện vì suy tim), mức độ đau ngực theo phân độ đau ngực của Hội Tim mạch Canada và mức độ suy tim theo phân độ suy tim của Hội Tim New York.
Kết quả: Tỷ lệ thành công về mặt kỹ thuật là 90,6%. Có 9,4% không thành công do không đưa bóng vào lại nhánh bên để thực hiện bước nong bóng đồng thời. Không ghi nhận tai biến trong quá trình can thiệp. Theo dõi 2 tháng sau can thiệp động mạch vành, tỷ lệ đau ngực và suy tim giảm rõ so với trước can thiệp. Không ghi nhận trường hợp nào có biến cố tim mạch chính.
Kết luận: Kỹ thuật Crush tối thiểu là kỹ thuật an toàn, giúp cải thiện triệu chứng đau ngực và suy tim cho bệnh nhân có tổn thương vị trí chia đôi động mạch vành.
Từ khóa: Can thiệp động mạch vành, tổn thương chia đôi động mạch vành, kỹ thuật Crush tối thiểu.
Risk Factors Affecting the Length of Improvement of Nutritional Status in Children with Congenital Heart Disease and Malnutrition
Authors: Aufie Athiyatul , Putra Sukman Tulus , Karyanti Mulya Rahma , Devaera Yoga 
Published: March 2023

Background: To date, limited data are available regarding the factors that contribute to the delay of improvement in nutritional status as well as data regarding the optimal duration to improve malnutrition among children with congenital heart disease (CHD). Such data are important for pediatricians to fully optimize the nutritional status for those children prior to surgical procedure This study aims to identify those aforementioned factors in hope for better surgical outcome and quality of life of children with CHD.
Methods: This is a descriptive analytic study using retrospective cohort design to identify the factors that contribute to the delay of improvement in nutritional status among children with CHD. Variables such as the type of CHD, classification of CHD complexity, pulmonary hypertension, heart failure, corrective surgery, the route of nutrition access, pneumonia, diarrhea, special diets and patients undergoing routine control at the nutrition outpatient clinic were evaluated in this study.
Results: A total of 216 children with a diagnosis of CHD and weight-for-length z-score under -1 SD were included in this study. Based on multivariate analysis, there were two significant risk factors, which were the occurrence of diarrhea and consulting at nutrition outpatient clinic. The improvement in nutritional status in children with CHD who did not have diarrhea was faster than those with diarrhea (HR 1.94; 95% CI 1.10 – 3.47) (p value <0.025). Improvement in nutritional status of those children that underwent control at the nutrition outpatient clinic was faster than those who did not (HR 1.87; 95% CI 1.20 – 2.92) (p value <0.006).
Conclusion: Risk factors that significantly lengthen the duration of improvement in the nutritional status of CHD patients were the incidence of diarrhea and those who did not undergo control at the nutrition outpatient clinic.
SOSIALISASI IMPLEMENTASI KURIKULUM MERDEKA BERDASARKAN PENGENALAN PLATFORM MERDEKA MENGAJAR
Authors: Anita Debora Simangunsong  , Marthin Fransisco Manihuruk  , Golda Novatrasio Sauduran  , Sahat Taruli Siahaan  , Lastri  Lastri  
Published: March 2023

Guru- guru di SD Negeri 064020 Medan memiliki kendala kurangnya pengetahuan tentang penerapan kurikulum merdeka. Solusi alternatif terhadap permasalahan yang dihadapi guru-guru di SD Negeri 064020 Medan, setelah dilakukannya sosialisasi pengetahuan tentang implementasi kurikulum merdeka berdasarkan pengenalan platform merdeka mengajar diharapkan dapat meningkatkan pengetahuan serta dapat menerapkan kurikulum merdeka di sekolah tersebut dengan mensosialisasikan kepada guru-guru SD Negeri 064020 Medan. Setelah sosialisasi dilakukan kepada guru-guru SD Negeri 064020 Medan maka tim pengusul akan melakukan evaluasi dengan cara memberikan tugas dan angket kepada guru-guru di SD Negeri 064020 Medan untuk diisi apakah hasil dari sosialisasi sudah memenuhi solusi yang diharapkan dari masalah guru-guru SD negeri 064020 Medan.
Pengaruh Customer Satisfaction dan Customer Trust Terhadap Customer Loyalty Pada Rumah Sakit X Di Gading Serpong Tangerang
Authors: Ade Yusup  , M. Rachman Mulyandi  
Published: March 2023

Tingginga kebutuhan masyarakat terhadap pelayanan kesehatan disambut baik oleh swasta. Terdapat 63% Rumah sakit di Indonesia di milii oleh swasta. Di Tangerang terdapat 15 Rumah sakit swasta tipe B yang satu dengan lainnya bersaing dalam melakukan kegiatan bisnis untuk mendapatkan pelanggan baru, tetapi juga meningkatkan loyalitas pelanggan lama atau customer loyalty. Penelitian ini bertujuan untuk mengetahui customer satisfaction, customer trust, dan customer loyalty. Selain itu juga untuk mengetahui pengaruh kepuasan pelanggan terhadap loyalitas pelanggan, pengaruh kepercayaan pelanggan terhadap loyalitas pelanggan, dan pengaruh kepuasan pelanggan dan kepercayaan pelanggan terhadap loyalitas pelanggan di rumah sakit X Gading Serpong Tangerang. Penelitian ini menggunakan pendekatan deskriptif kuantitatif. Populasi penelitian ini adalah pasien rumah sakit X Gading Serpong Tangerang yang berjumlah 120 orang. Sedangkan jumlah sampel dalam penelitian ini adalah 90 pasien. Hasil penelitian menunjukkan bahwa customer satisfaction, customer trust, dan customer loyalty masing-masing pasien termasuk dalam kategori “Baik”. Dari hasil perhitungan korelasi diketahui bahwa secara parsial variabel customer satisfaction, customer trust berpengaruh positif dan signifikan terhadap customer loyalty pasien Rumah sakit X di Gading Serpong Tangerang. Hasil uji F menunjukkan bahwa customer satisfaction (X1) dan customer trust (X2) secara simultan berpengaruh positif dan signifikan terhadap variabel customer loyalty (Y) dengan nilai F hitung (46,673) > F tabel (3,10).
Pengaruh Penerapan Prinsip Non-diskriminasi Gender terhadap Pengembangan Karir dan Kepuasan Kerja di Perusahaan Penyedia Layanan Jalan Tol (Studi Kasus pada PT. Jasa Marga (Persero)
Authors: Cynthia Vanessa Djodjobo  , Rut Gloria Anugrah  , Langga Lagandhy  
Published: March 2023

Beberapa fenomena yang terjadi di dunia kerja menurut Data European Commision, World Bank dan Badan Pusat Statistik mengenai data distribusi jabatan manajer menurut jenis kelamin menunjukkan hasil yang sama yaitu persentase perempuan menduduki posisi manajerial lebih rendah dari laki-laki. Hal ini mengindikasikan keterbatasan peluang untuk mengembangkan karir di tempat kerja bagi pekerja perempuan. Berdasarkan data tersebut, diskriminasi gender berkorelasi dengan pengembangan karir yang selanjutnya menjadi salah satu faktor penentu kepuasan kerja pekerja. Penelitian ini bertujuan untuk mengetahui pengaruh Penerapan prinsip non-diskriminasi gender dan pengembangan karir terhadap kepuasan kerja di perusahaan penyedia layanan jalan tol (PT. Jasa Marga (Persero)). Penelitian ini menggunakan pendekatan kuantitatif dengan studi deskriptif dan klausul. Data yang diperoleh merupakan hasil pengisian kuesioner dari 45 sampel yang merupakan karyawan PT. Jasa Marga Kantor Regional Jakarta dengan menggunakan teknik random sampling. Hasil penelitian menunjukkan bahwa penerapan prinsip non-diskriminasi gender tidak berpengaruh terhadap kepuasan kerja, pengembangan karir berpengaruh positif terhadap kepuasan kerja, penerapan prinsip non-diskriminasi gender dan pengembangan karir secara simultan berpengaruh positif terhadap kepuasan kerja. Penelitian berikutnya diharapkan dapat mengkaji lebih dalam bagaimana pengaruh dari sub variabel untuk variabel penerapan prinsip non-diskriminasi gender dan pengembangan karir terhadap kepuasan kerja.
PENGEMBANGAN LEMBAR KERJA PESERTA DIDIK ELEKTRONIK (E-LKPD) PADA MATERI TEKS NEGOSIASI SISWA KELAS X SMAN 1 SAROLANGUN
Authors: Weny Septiani  , Amril Amir  
Published: March 2023

Penelitian ini bertujuan untuk mendeskripsikan bagaimana perancangan model E-LKPD berbasis discovery learning, bagaimana mengembangkan E-LKPD berbasis discovery learning, dan menganalisis kelayakan E-LKPD berbasis discovery learning pada materi teks negosiasi untuk dikembangkan SMA Negeri 1 Sarolangun. Jenis penelitian ini adalah penelitian pengembangan yang mengadopsi pengembangan 4D (Define, Design, Developmet, Disseminate) dengan modifikasi, tanpa tahap disseminate (penyebaran). Langkah penelitian dan pengembangan tersebut yaitu Identifikasi dan analisis masalah, perancangan, pengembangan, dan validasi produk. Instrument penelitian berupa lembar wawancara guru, angket analisis kebutuhan siswa, lembar validasi ahli materi, ahli media yang dianalisis menggunakan skala likert. Hasil penelitian menunjukkan bahwa: (1) telah dirancang E-LKPD berbasis discovery learning dengan pengembangan pada aspek materi teks negosiasi, (2) setelah dilakukan perancangan maka selanjutnya dikembangkan E-LKPD berbasis discovery learning pada materi teks negosiasi melalui palatform liveworksheets, (3) kelayakan pengembangan E-LKPD berbasis discovery learning yang dinilai oleh ahli materi berada pada kategori sangat valid (91,2%) atau dinyatakan layak untuk digunakan dan menurut ahli media E-LKPD yang dikembangkan berada dalam kategori valid (87,5%) atau dinyatakan layak digunakan. Dengan demikian dapat disimpulkan bahwa E-LKPD berbasis discovery learning dapat digunakan dalam proses pembelajaran di SMA
Selling the American People
Authors: McGuigan Lee 
Published: March 2023

How marketers learned to dream of optimization and speak in the idiom of management science well before the widespread use of the Internet.
Algorithms, data extraction, digital marketers monetizing "eyeballs": these all seem like such recent features of our lives. And yet, Lee McGuigan tells us in this eye-opening book, digital advertising was well underway before the widespread use of the Internet. Explaining how marketers have brandished the tools of automation and management science to exploit new profit opportunities, Selling the American People traces data-driven surveillance all the way back to the 1950s, when the computerization of the advertising business began to blend science, technology, and calculative cultures in an ideology of optimization. With that ideology came adtech, a major infrastructure of digital capitalism.
To help make sense of today's attention merchants and choice architects, McGuigan explores a few key questions: How did technical experts working at the intersection of data processing and management sciences come to command the center of gravity in the advertising and media industries? How did their ambition to remake marketing through mathematical optimization shape and reflect developments in digital technology? In short, where did adtech come from, and how did data-driven marketing come to mediate the daily encounters of people, products, and public spheres? His answers show how the advertising industry's efforts to bend information technologies toward its dream of efficiency and rational management helped to make "surveillance capitalism" one of the defining experiences of public life.
Sewer of Progress
Authors: McCulligh Cindy 
Published: March 2023

A creative and comprehensive exploration of the institutional forces undermining the management of environments critical to public health.
For almost two decades, the citizens of western Mexico have called for a cleanup of the Santiago River, a water source so polluted it emanates an overwhelming acidic stench. Toxic clouds of foam lift off the river in a strong wind. In Sewer of Progress, Cindy McCulligh examines why industrial dumping continues in the Santiago despite the corporate embrace of social responsibility and regulatory frameworks intended to mitigate environmental damage. The fault, she finds, lies in a disingenuous discourse of progress and development that privileges capitalist growth over the health and well-being of ecosystems.
Rooted in research on institutional behavior and corporate business practices, Sewer of Progress exposes a type of regulatory greenwashing that allows authorities to deflect accusations of environmental dumping while “regulated” dumping continues in an environment of legal certainty. For transnational corporations, this type of simulation allows companies to take advantage of double standards in environmental regulations while presenting themselves as socially responsible and green global actors. Through this inversion, the Santiago and other rivers in Mexico have become sewers for urban and industrial waste. Institutionalized corruption, a concept McCulligh introduces in the book, is the main culprit, a system that permits and normalizes environmental degradation, specifically in the creation and enforcement of a regulatory framework for wastewater discharge that prioritizes private interests over the common good.
Through a research paradigm based in institutional ethnography and political ecology, Sewer of Progress provides a critical, in-depth look at the power relations subverting the role of the state in environmental regulation and the maintenance of public health.