bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical Characteristics and Prognostic Factors in H3 K27- altered Diffuse Midline Gliomas: A 64 Cases Retrospective Cohort Analysis
Authors: Zhao Liqian , Song Zibin , Fang Luxiong , Zeng Yu , Han Lei , Zhan Zhengming , Chai Peng , Ji Ke , Chen Ruizhe , He Ziting , Huang Guanglong , Pan Jun , Song Ye 
Published: September 2023

Abstract
Purpose
This study aims to systematically assess patient characteristics, identify clinical factors guiding treatment decisions, and predict the prognosis of H3 K27-altered Diffuse Midline Glioma (DMG/K27M).
Methods
A retrospective review of 64 consecutive DMG/K27M patients was conducted. Patient clinical profiles, treatment approaches, and follow-up data were collected from a Chinese tertiary institution between August 2016 and August 2022. Analysis of overall survival (OS) was conducted using Kaplan–Meier modeling and univariate and multivariate Cox regression analyses to identify prognostic factors.
Results
Among the 64 patients included in the study, the median OS was 9 months. Thalamus was the tumor location for 53.1% (34/64), with 39.1% (25/64) presenting dizziness as their initial symptom. Patients with dizziness were younger (23.04 vs. 30.7 years, p = 0.0328), exhibited larger tumor volume (27.380 vs. 11.680 cm3, p = 0.0359), and displayed extended overall survival (13.00 vs. 8.00 months, p = 0.0017) compared to those without dizziness. In addition, univariate and multivariate analysis showed that tumor location, dizziness, Karnofsky performance status (KPS) score and treatment regimen were prognostic factors for OS (p < 0.05), whereas age was not significantly correlated with OS.
Conclusion
Patients without dizziness as the initial symptom may face a challenging prognosis compared to the dizziness (+) group. Tumor location, dizziness, KPS, and treatment regimen could serve as independent prognostic indicators. These findings contribute novel insights for evidence-based practices in DMG/K27M research.
An Innovative Method of Bracket Positioning using Augmented Reality: A Clinical Insight
Authors: Hegab Seif El-Din , Sharaby Fouad El , Eid Faten , Abd-El-Ghafour Mohamed 
Published: September 2023

Abstract
Background/objectives: Augmented reality (AR) might be a useful concept to change the future of the orthodontic practice. The aim of this article is to introduce a novel method integrating AR to aid in bracket placement with virtually pre-planned positions without a transfer tray.
Methods: For a 30-year-old female patient, bracket positions of the upper model are virtually planned on specialized software, the resulting data is then transferred via a smartphone application, which was used in combination with a VR headset to aid the operator in viewing markers denoting the precise positions of the brackets on the model.
Results: Brackets were successfully transferred using the AR-guided method onto the printed model, simulating the actual process in-vivo.
Conclusions: The proposed method has proven helpful in easily identifying the precise bracket positions, however further clinical testing is underway for validation of accuracy of the transfer method.
Measurement of the Spatiotemporal Disparities in the Equalization Level of Basic Medical and Health Services in China: An Empirical Study Based on Provincial Panel
Authors: Fan Hailong , Wei Haibin 
Published: September 2023

Abstract
Objective This study aims to explore the spatiotemporal disparities in the equalization of basic medical and health services in China, in order to provide reference and guidance for promoting the equalization process of basic medical and health services and ensuring the fair enjoyment of citizens' right to life and health.
Methods Based on the theory of Structure-Process-Outcome(SPO), a comprehensive evaluation index system of equalization level was constructed with 22 core indicators of basic medical and health services, from the three dimensions of medical and health investment, health service utilization, and medical service effectiveness. The Generalized Principal Component Analysis (GPCA) model was used to calculate the equalization level of basic medical and health services in 31 provinces, municipalities, and autonomous regions from 2011 to 2021. Furthermore, the kernel density estimation and Moran’s I model was employed to analyze the correlation and disparity at the spatial level.
Results 1. From a national perspective, the level of equalization of basic medical and health services in China has significantly improved from 2011 to 2021. The mean score of national equalization level increased from -0.605 to 0.174, with an increase of 128.75%. 2. From the perspective of spatiotemporal disparities between regions, the level of equalization shows a spatial distribution pattern of "higher in the east and lower in the west", decreasing from coastal areas to inland and from the east to the west. 3. From the perspective of spatiotemporal disparities within regions, from 2011 to 2021, there has been a certain improvement in the intraregional disparity in the Eastern and Western parts, while the intraregional disparity in the Central and Northeastern parts has further intensified. 4. From the perspective of spatial interconnection among provinces, there is a strong spatial correlation in the level of equalization of basic medical and health services in China. However, the spatial distribution of agglomeration centers and isolated points shows an east-west differentiation trend.
Conclusion From 2011 to 2021, the level of equalization of basic medical and health services in China has significantly improved, but the disparities among regions have become more evident. Disparities among regions have replaced inter-provincial disparities as the main factor influencing the level of equalization of basic medical and health services in China. It is recommended to enhance the spatial balance of the level of equalization of basic medical services in China, based on the fully utilization of spatial correlation and agglomeration among provinces.
Supported Employment, Demographic Covariates, and Adjunctive Vocational Rehabilitation Services as Predictors of Competitive Integrated Employment for Young Adults with Intellectual and Developmental Disabilities: A Hierarchical Logistic Regression Analysis
Authors: Iwanaga Kanako , Wehman Paul , Schall Carol , Avellone Lauren , Chan Fong , Inge Katherine , McDonough Jennifer 
Published: September 2023

Abstract
Purpose
Compelling evidence strongly supports competitive integrated employment (CIE) as a driving force for improving the economic well-being, as well as the physical and mental health, and overall quality of life for individuals with Intellectual and Developmental Disabilities (IDD). However, the employment participation rate for those with IDD remains notably lower than those without IDD. Supported Employment (SE) is evidence based vocational rehabilitation intervention, which offers personalized workplace support necessary for successful performance within CIE settings. This study aims to predict CIE outcome for youth and young adults with IDD by evaluating demographic variables, SE, and adjunctive state vocational rehabilitation agency (SVRA) services.
Methods
This study sample included 67,884 youth and young adults with IDD extracted from the U.S. Department of Education's Rehabilitation Services Administration Case Service Report dataset. Our analytical approach was logistic regression analysis.
Results
The findings indicated that SE had a highly significant association with positive CIE outcomes. Participants who received SE were considerably more likely to achieve CIE compared to those who didn't. Adjunctive SVRA services also played a crucial role, with notable differences in CIE odds between those who received workplace support, job placement assistance, and job search assistance and who didn’t. The final model explained 27% variance in a CIE outcome.
Conclusions
These findings underscore the efficacy of SE in supporting youth and young adults with IDD in achieving CIE. Consequently, this study's insights hold potential to guide vocational rehabilitation professionals in optimizing SE delivery alongside adjunctive SVRA services.
Taurine an ecofriendly bioorganic catalyst for the synthesis of dihydropyrido [2,3-d] pyrimidine and pyrimido[4,5-b]quinoline derivatives under ultrasonication
Authors: Polke Bhavana G. , Bhosle Manisha R. , Bondle Giribala M. 
Published: September 2023

Abstract
Ultrasound-assisted multicomponent reaction in aqueous taurine as an efficient and green method developed for the synthesis of 5-phenyl-5,6-dihydropyrido [2,3-d] pyrimidine-2,4,7(1H,3H,8H)-triones and 5-(phenyl)-8,9-dihydro-8,8-dimethylpyrimido[4,5-b]quinoline-2,4,6(1H,3H,5H,7H,10H)-triones in excellent yields with high purity. In the present work, 2-amino ethane sulfonicacid (Taurine) as green bio-organic catalyst is used for the cyclocondensation of substituted aldehydes, 6-amino uracil and meldrum acid/dimedone in water under ultrasonication. The key benefits of the present methodology are the use of cheap universal solvent water, recyclability of bioorganic catalyst, less reaction time, high yields of the product and avoiding toxic chemicals.
Perception of livestock farmers towards occupational health and hazards in Ibadan, Nigeria
Authors: Busari Ibukun 
Published: September 2023

Abstract
Aim
The National Safety Council categorises the agrifood sector as the industry with the highest death rate per 100,000 workers in 2021. Ibadan, a major hub of livestock and micro-livestock production in Nigeria, has little or no documentation on farmers' perceptions of occupational health and safety.
Methods
A field survey was carried out among 151 livestock producers in Ibadan between July and September 2022, using open- and closed-ended questionnaires. A cross-tabulation was used to quantitatively compare the variables using Pearson’s Chi square to determine the level of significance.
Results
More than 78% of the male farmers agree and/or strongly agree that they could forego a few workplace safety precautions, while 66% strongly disagree that personal safety is important. Prior to this study, 76% and 23.5% of livestock farmers, male and female, respectively, claimed they had not heard about workplace health and safety. On a scale of 0.0 to 4.5, the average perception index score of respondents on occupational safety and health (OSH) revealed that 2.01 indicated that the OSH Act is not useful, 1.88 stated that the OSH Act is ineffective at reducing injuries and illnesses, and 1.72 opined that the OSH Act is not applicable to their job. Close to 100% of the farming population in Ibadan had access to media and smart devices, which could be explored in the dissemination of health and safety information to improve occupational safety and health awareness.
Conclusion
Smart technological channels should be harnessed to disseminate occupational health and safety information to workers in the agrifood sector.
Wildfire worsens population exposure to PM2.5 pollution in the Continental United States
Authors: Zhang Danlu , Wang Wenhao , Xi Yuzhi , Bi Jianzhao , Hang Yun , Zhu Qingyang , Pu Qiang , Chang Howard , Liu Yang 
Published: September 2023

Abstract
As wildfires become more frequent and intense, fire smoke has significantly worsened ambient air quality, posing greater health risks. To better understand the impact of wildfire smoke on air quality, we developed a modeling system to estimate daily PM2.5 concentrations attributed to both fire smoke and non-smoke sources across the Continental U.S. We found that wildfire smoke has the most significant impact on air quality in the West Coast, followed by the Southeastern U.S. Between 2007 and 2018, fire smoke affected daily PM2.5 concentrations at 40% of all regulatory air monitors in EPA's Air Quality System (AQS) for more than one month each year. People residing outside the vicinity of an EPA AQS monitor were subject to 36% more smoke impact days compared to those residing nearby. Lowering the national ambient air quality standard (NAAQS) for annual mean PM2.5 concentrations to between 9 and 10 µg/m3 would result in approximately 29% to 40% of the AQS monitors falling in nonattainment areas without taking into account the contribution from fire smoke. When fire smoke impact is considered, this percentage would rise to 35% to 49%, demonstrating the significant negative impact of wildfires on air quality.
Combined experimental and theoretical approach to improve measurement accuracy of temperature-dependent reflectance of copper
Authors: Mattern Manuel , Kukreja Lalit Mohan , Ostendorf Andreas 
Published: September 2023

Abstract
The low process stability of laser welding of copper with near infrared lasers leads to the requirement of precise input data for process control and meaningful simulations. But at the same time, available datasets of temperature-dependent reflectance or absorptance for near infrared lasers on copper do not show good agreement between the different sources and often do not include the fusion process, which is of crucial importance for realistic laser welding simulations. Additionally, most of the datasets are only calculated. We recently performed temperature-dependent reflectance measurements on copper using a near infrared laser. The measurements revealed a reflectance drift, which is induced by the setup behavior during heating, and the time-dependence of chemical reactions like the redox-reaction as possible error sources. In this study, we performed experiments on laser melting as the fundamental process of laser welding, and we conducted corresponding simulations using our measured reflectance values for oxide-reduced and for untreated copper. We then compared the simulations with the experiments to estimate the accuracy of our reflectance measurements. To provide context, we also conducted the same simulations using reflectance datasets from other authors. In a second step, we corrected our reflectance data with respect to the reflectance drift and adapted the effects of redox reactions to the conditions of our laser melting experiments. Using the resulting reflectance curves, we achieved an improved agreement of simulation results and the experiments over a range of different test cases, without the necessity of correction factors in the simulation model.
Clinical Spectrum of Adult-Onset Still’s Disease in Patients Presenting At A Tertiary Care Hospital in Pakistan: A 16-Year Follow-Up Study
Authors: Riaz Mehmood , Arshad Ainan , Baqir Syed Mujtaba , Isra Ahmed , Karim Zohair 
Published: September 2023

Abstract
Objectives
Adult-onset Still’s Disease (AOSD) is a rare systemic auto-inflammatory disorder with a low incidence rate and limited data. This study aims to lay down the clinical and laboratory spectrum, associated complications, and outcomes of patients who presented to a tertiary care center – in order to identify any regional variation in the presentation and enable physicians to develop a thought process in patients without characteristic features.
Materials and Methods
We reviewed the records of patients from January 2005 - February 2021 who presented with symptoms consistent with AOSD, using the Yamaguchi criteria. The patients’ clinical symptoms, laboratory values, therapeutic management, complications, and outcomes were analysed. Descriptive statistics were produced to illustrate the pattern of the disease.
Results
The mean age of patients was 37.7 years, with a male to female ratio of 1:1. Fever and arthralgia was seen in 90%, a salmon-coloured rash in 60%, and leukocytosis in 80%. 30% presented with a sore throat and recent lymphadenopathy, 40% with hepatomegaly and/or splenomegaly on imaging, 100% with abnormal liver function tests. Steroids were used as first-line treatment. Most patients did not present with common, previously reported, complications of AOSD.
Conclusions
The clinical aspects in this study are, to a large part, comparable to those seen in other parts of the world. Thus, a comprehensive analysis of AOSD would enable physicians to broaden their minds and keep it as a top differential in atypical presentations – enhancing patient care by preventing a delay in diagnosis and initiation of prompt management.
Evaluating the impact of ponds on flood and drought mitigation in the Bagmati River Basin, Nepal
Authors: Gautam Kabita , Corzo Gerald 
Published: September 2023

Abstract

This study investigates the effectiveness of ponds as a nature-based solution (NBS) to concurrently ameliorate flood and drought impacts, emphasizing the need for an integrated response to multi-extreme hydrological events. We incorporate ponds into agricultural landscapes in the Bagmati River Basin of Nepal and assess their performance using the Soil and Water Assessment Tool (SWAT+). Six different scenarios are thoroughly explored to see how these interventions affect the main components of the water balance, such as surface run-off, lateral flow, percolation, and evapotranspiration. The spatial efficiency of the ponds, particularly in their immediate surroundings and downstream areas, has been proven to be a crucial factor in their overall efficacy in attenuating extremes, which increases with the size of the intervention area. Although the effects of ponds on floods and droughts are minor, they could be significantly magnified by a synergistic use of other NBS tactics, such as conservation tillage or soil conservation techniques. Future studies should establish the most appropriate sites and volumes for these interventions, as well as further investigate the possible advantages of several NBS, to optimize flood and drought management in the Bagmati River Basin and other similarly susceptible places.
Potential Determinants Contributing to COVID-19 Vaccine Acceptance and Hesitancy in Taiwan: Rapid Qualitative Mixed Methods Study
Authors: Lin Li-Yin , Lin Chun-Ji , Kuan Chen-I , Chiou Hung-Yi 
Published: September 2023

Background
Although vaccination has been shown to be one of the most important interventions, COVID-19 vaccine hesitancy remains one of the top 10 global public health challenges worldwide.

Objective
The objective of this study is to investigate (1) major determinants of vaccine hesitancy, (2) changes in the determinants of vaccine hesitancy at different time periods, and (3) the potential factors affecting vaccine acceptance.

Methods
This study applied a mixed methods approach to explore the potential determinants contributing to vaccine hesitancy among the Taiwanese population. The quantitative design of this study involved using Google Trends search query data. We chose the search term “疫苗“ (vaccine), selected ”台灣” (Taiwan) as the location, and selected the period between December 18, 2020, and July 31, 2021. The rising keywords related to vaccine acceptance and hesitancy were collected. Based on the responses obtained from the qualitative study and the rising keywords obtained in Google Trends, the 3 most popular keywords related to vaccine hesitancy were identified and used as search queries in Google Trends between December 18, 2020, and July 31, 2021, to generate relative search volumes (RSVs). Lastly, autoregressive integrated moving average modeling was used to forecast the RSVs for the 3 keywords between May 29 and July 31, 2021. The estimated RSVs were compared to the observed RSVs in Google Trends within the same time frame.

Results
The 4 prevailing factors responsible for COVID-19 vaccine acceptance and hesitancy were doubts about the government and manufacturers, side effects, deaths associated with vaccination, and efficacy of vaccination. During the vaccine observation period, “political role” was the overarching consideration leading to vaccine hesitancy. During the peak of the pandemic, side effects, death, and vaccine protection were the main factors contributing to vaccine hesitancy. The popularity of the 3 frequently searched keywords “side effects,” “vaccine associated deaths,” and “vaccine protection” continued to rise throughout the pandemic outbreak. Lastly, the highest Google search queries related to COVID-19 vaccines emerged as “side effects” prior to vaccination, deaths associated with vaccines during the period when single vaccines were available, and “side effects” and “vaccine protection” during the period when multiple vaccines were available.

Conclusions
Investigating the key factors influencing COVID-19 vaccine hesitancy appears to be a fundamental task that needs to be undertaken to ensure effective implementation of COVID-19 vaccination. Google Trends may be used as a complementary infoveillance tool by government agencies for future vaccine policy implementation and communication.
Effect of Individual Virtual Reality Cognitive Training Programs on Cognitive Function and Depression in Middle-Aged Women: Randomized Controlled Trial
Authors: Kim Du-Ri , Moon EunSoo , Shin Myung-Jun , Yang Yeong-Ae , Park Jong-Hwan 
Published: September 2023

Background
Given the increasing incidence of early-onset Alzheimer disease, strategies for early diagnosis and swift treatment interventions are crucial for mitigating cognitive problems in women and middle-aged individuals who face a high risk of cognitive impairment.

Objective
This study aimed to assess the effectiveness of individual cognitive training programs based on virtual reality (VR), a nonpharmacological intervention, on cognitive function and depression in middle-aged women at risk of cognitive impairment. It used VR technology, which has recently been recognized as a promising tool.

Methods
We administered a VR-based cognitive training program for 30 minutes daily, twice a week, for 12 weeks (24 sessions). This study included middle-aged women residing in older adults’ welfare facilities in G-gu, Busan, from May to August 2021. A total of 60 participants were randomly divided into the training (n=30) and control (n=30) groups. Cognitive and depressive functions were assessed using the Korean versions of the Montreal Cognitive Assessment (K-MoCA), Digit Span Test (DST), Korean-Color Word Stroop Test (K-CWST), and Short Form of the Geriatric Depression Scale (SGDS-K) before the intervention. The training group underwent a VR-based cognitive training program, whereas the control group was educated to maintain regular daily activities. The same assessments were performed 12 weeks after treatment.

Results
A comparison of the mean scores before and after K-MoCA in the training group revealed a significant increase from 24.87 (SD 2.62) to 27.50 (SD 1.70; P<.01), indicating substantial cognitive improvement. Similarly, the mean DST forward scores increased significantly from 6.97 (SD 1.10) to 7.90 (SD 1.18; P<.01), suggesting enhanced short-term auditory memory and attention. The mean DST backward scores also showed a significant improvement from 4.10 (SD 0.71) to 4.77 (SD 1.2; P=.01). Notably, the mean SGDS-K scores decreased significantly from 3.97 (SD 2.51) to 2.13 (SD 1.87; P<.01), indicating a reduction in depression within the training group.

Conclusions
The VR-based cognitive training programs significantly enhanced cognitive function and reduced depression in middle-aged women. Consequently, these programs are considered beneficial nonpharmacological cognitive training interventions for middle-aged women at high risk of cognitive impairment.

Trial Registration
UMIN Clinical Trials Registry UMIN000049752; https://tinyurl.com/z5du989z