bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genus Knema: An Extensive Review on Traditional Uses, Phytochemistry,
and Pharmacology
Authors: Hop Nguyen Quang , Son Ninh The 
Published: February 2023

Background:
Knema (the Myristicaceae family) is a large genus of small-medium trees
found in Southeast Asia, Africa, and Australia. Historical records dealt with the uses of Knema
species as medicinal plants against various diseases, especially cancer remedies, or their application
as tonic agents in Asian communities

Objective:
The aim of this review is to provide the most current knowledge on the traditional uses,
chemical profiles, as well as pharmacological values of Knema plants.

Methods:
Through electronic search, the literature materials on Knema plants were acquired from
scholarly journals, books, and internationally recognized scientific databases, such as PubMed,
ScienceDirect, Sci-Finder, Web of Science, and Google Scholar. All full-text articles and abstracts
on Knema were screened. Genus Knema, traditional use, phytochemistry, and pharmacology were
the first selective keywords to search for references.

Results:
Since the 1970s, more than 185 metabolites have been isolated from Knema plants and
structurally elucidated. Among them, phenolic lipids, flavonoids, and lignans are the principal
metabolites. Crude extracts, fractions, and isolated compounds of Knema species possess a wide
variety of pharmacological properties, such as antioxidative, antidiabetic, antimicrobial, antiinflammatory,
antimalarial, neuroprotective, and hepatoprotective activities, but cytotoxicity is the
most striking feature. Phenolic lipids containing long alkyl side chains and polar hydroxyl or acyl
groups are found as the most active molecules in cytotoxic assays.

Conclusion:
Further studies on phytochemistry and pharmacological activities, toxicological assessments,
pharmacological mechanisms, and pharmacokinetics are urgently needed.
Therapeutic Monoclonal Antibodies for Non-Hodgkin Lymphoma: A
Literature Review
Authors: Fallahi Mohammad Sadegh , Zerangian Nasibeh , Ghorbani Atousa , Erabi Gisou , Shirali Melika , Shabani Elaheh , Rommasi Foad , Najafabadi Mahsa Mohammadi , Karbasi Shima , Toutounchian Samaneh , Ahangar-Sirous Ramin , Motaghy Ava , Heidari Mahsa , Deravi Niloofar 
Published: February 2023

Abstract:
Non-Hodgkin lymphoma (NHL) occurs in the lymphatic system because of lymphocytes tumor. This type of tumor has a high death rate among patients. In recent years, a lot of progress has been made based on understanding its exact biology; several treatment methods have been developed. Many patients are cured by a combination of different chemotherapies, despite their toxic effects. In recent years, despite various studies on monoclonal antibodies for non-Hodgkin lymphoma, there have been no narrative articles in this field. Therefore, combining monoclonal antibodies with chemotherapy is successful as they reduce the toxic side effects of chemotherapies. These antibodies can target specif-ic cellular pathways of the immune system leading to limitation of cancer progression. In this article, various types of monoclonal antibodies, their underlying mechanisms of action, as well as their effects on patients with different phases and types of Non-Hodgkin lymphoma have been reviewed for a better understanding.
Exposure to Pornography and Adolescent Sexual Behavior: Systematic Review
Authors: Pathmendra Pranujan , Raggatt Michelle , Lim Megan SC , Marino Jennifer L , Skinner S Rachel 
Published: February 2023

Background
Formative experiences in adolescence lay the foundation for healthy and pleasurable romantic and sexual relationships. Exposure to pornography may affect these experiences.

Objective
We aimed to synthesize evidence published in the past decade on the relationship between exposure to pornography and sexual behavior (earlier age of first sex [<16 years], condomless sex, past-year multiple partners [>1], lifetime multiple partners [>1], group sex, sexual aggression including forced sex, paid sex, teenage pregnancy, and history of sexually transmitted infection) in adolescents aged between 10 and 19 years.

Methods
We identified 19 eligible studies by searching MEDLINE, PsycINFO, Cochrane, CINAHL, Embase, and Web of Science databases from January 2010 to November 2022.

Results
Out of 8 studies that assessed earlier age of first sex, 5 studies, including 1 longitudinal study, found a statistically significant association with exposure to pornography. Given that most studies were cross-sectional or had substantial limitations, causal inference could not be made. Also, exposure to pornography was not measured consistently. The evidence was conflicting or insufficient to draw any conclusions regarding other outcomes.

Conclusions
More quantitative research is needed to elucidate the association between pornography exposure and sexual behavior, and sex education should adopt evidence-based approaches to minimize the potential harms from pornography.

Trial Registration
PROSPERO International Prospective Register of Systematic Reviews CRD42021227390; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=227390
Inclusion of Participants with CKD and Other Kidney-Related Considerations during Clinical Drug Development
Authors: Butrovich Morgan A. , Reaves Allison C. , Heyward Jamie , Moore Thomas J. , Alexander G. Caleb , Inker Lesley A. , Nolin Thomas D. 
Published: February 2023

Background
The US Food and Drug Administration has prioritized efforts to expand availability of therapies, including anticancer agents, for patients with CKD. US Food and Drug Administration Guidance recommends inclusion of study participants with CKD in clinical trials, improving pharmacokinetic characterization in people with decreased GFR, and using contemporary GFR assessment methods during drug development. We performed a landscape analysis of anticancer agents approved from 2015 to 2019 to evaluate inclusion of study participants with CKD and GFR assessment methods used during drug development and subsequent translation to kidney-related safety and dosing data in product labeling.

Methods
Oncology drugs approved from 2015 to 2019 and associated pivotal trials were identified. We evaluated inclusion of study participants with CKD in pivotal trials and pharmacokinetic analyses, investigated GFR assessment methods used for pivotal trial eligibility and renal pharmacokinetic analyses, and identified kidney-related adverse drug event and dosing information.

Results
A total of 55 drugs and 74 pivotal trials were included. Of the pivotal trials, 95% contained kidney-related eligibility criteria, including 68% with GFR-based eligibility. The median lower limit of GFR required for inclusion was 45 ml/min or ml/min per 1.73 m2. Pharmacokinetic analyses were performed in CKD stages 4–5 and hemodialysis for only 29% and 6% of drugs, respectively. Estimated creatinine clearance was used in over 60% and 80% of pivotal trials and pharmacokinetic analyses, respectively. Reporting of kidney-related adverse drug events was highly variable. Product labeling for 49% of drugs contained no kidney dosing information.

Conclusions
Study participants with CKD continue to be excluded from anticancer drug development, and GFR estimation in pivotal trials and renal pharmacokinetic analyses remains imprecise and heterogeneous. Furthermore, kidney-related safety and dosing information is scarcely and inconsistently presented.
Pengembangan Potensi Usaha Masyarakat Untuk Mewujudkan Kemandirian Ekonomi Melalui Transformasi Digital di Desa Sambirata, Kecamatan Cilongok, Kabupaten Banyumas
Authors: Rina Mudjiyanti  , Naelati Tubastuvi  , Rezky Pramurindra  , Sulistyani Budiningsih  , Aji Mukhlis Prasetyo 
Published: February 2023

Program pengabdian masyarakat dengan judul Pengembangan Potensi Usaha Masyarakat Untuk Mewujudkan Kemandirian Ekonomi Melalui Transformasi Digital, bertujuan untuk meningkatkan skala usaha BUMDes dan Karang Taruna Desa Sambirata dalam menghadapi tantangan dan peluang usaha di era digital. Permasalahan yang dihadapi oleh mitra adalah, keterbatasan akses internet di desa Sambirata. Kedua terbatasnya saluran distribusi pemasaran, karena minimnya pengetahuan tentang digital marketing dan minimnya pengetahuan tentang marketplace sebagai platform bisnis online. Ketiga, pengembangan usaha melalui peningkatan kemampuan usaha secara digital. Keempat, peningkatan kemampuan pemasaran digital melalui aplikasi e-commerce. Manfaat yang diperoleh pelaku usaha BUMDes dan Karang Taruna adalah pertama, pemerataan akses internet, kedua peningkatkan literasi digital, ketiga peningkatan kemampuan pengelolaan usaha secara digital dan keempat peningkatan kemampuan pengemasan produk dan pemasaran digital. Perlu adanya effort dan strategi bisnis untuk menyakinkan pelaku usaha dalam menghadapi ketidakpastian masa depan. Kegiatan pengabdian masyarakat mampu meningkatkan skala usaha (scale-up) pelaku ekonomi Desa. Melalui BUMDes dan Karang Taruna, pelaku usaha Desa mulai bertransformasi digital memanfaatkan teknologi dalam pemasaran produk. Google my business digunakan BUMDes Ngudi Makmur sebagai salah satu strategi digital marketing untuk meningkatkan aksesibilitas dan konektivitas dengan masyarakat. Masyarakat semakin mudah untuk memperoleh informasi mengenai produk Kapulaga sebagai komoditi unggulan Desa Sambirata. Hal ini didukung dengan pemerataan akses internet di area Desa Sambirata. Aplikasi e-commerce melalui pasarsambirata.com mampu meningkatkan daya saing produk usaha Desa. Melalui BUMDes dan Karang Taruna, pelaku usaha Desa dapat mempromosikan dan bertransaksi secara online dengan konsumen. Hal ini tentunya dapat meningkatkan pendapatan usaha sehingga diharapkan kemandirian ekonomi desa dapat terwujud.
EFEITO DA REMUNERAÇÃO COMO INCENTIVO GERENCIAL AO RISCO E AGRESSIVIDADE TRIBUTÁRIA NO BRASIL
Authors: Mamede Junior Eony , Vianna Brugni Talles , Soares Monte-Mor Danilo , Xavier Beiruth Aziz 
Published: February 2023

Objetivo: O objetivo desta pesquisa foi investigar o efeito da remuneração como incentivo gerencial ao risco, medido por intermédio da estrutura de remunerações dos executivos, sobre a agressividade tributária no Brasil, no período de 2010 a 2021.
Método / abordagem: Foi proposto um modelo em regressão linear com dados em painel e efeito fixo de tempo e setor. Dentre as diversas medidas utilizadas na literatura internacional e nacional, utilizou-se nesta pesquisa quatro delas: a ETR, Cash ETR, ETR corrente e BTD. Contudo, no Brasil, dada a abrangência e importância dos tributos indiretos na carga tributária, é possível que a medida taxa de tributação representada na DVA possa representar melhor a agressividade tributária no Brasil. Analisou-se também se o cenário econômico pós-impeachment representou incentivos para as empresas em termos de agressividade tributária.
Principais resultados: Destaque para a captura da agressividade tributária pelas métricas taxas de tributações sobre o valor adicionado.
Contribuições metodológicas / sociais / gerenciais: O fato de o país ora estar diante de um governo com viés mais liberal (e ora diante de um viés contrário), pode representar fundamentos para os achados, isto é, maior (menor) agressividade tributária. Assim sendo, uma contribuição social é que o efeito do incentivo gerencial ao risco relacionada com agressividade tributária pode reduzir a capacidade do governo em investir em bens públicos, conforme menciona a Teoria das Finanças Públicas. A contribuição gerencial deriva do fato de que maior incentivo a remuneração conduz a maior agressividade tributária, e, que talvez seja necessário maiores mecanismos de controles internos.
Originalidade / relevância: O estudo se justifica na medida que, em uma visão neoliberal, pode evidenciar que essa forma de governo pode induzir as empresas a maior agressividade tributária, principalmente quando a empresa remunera melhor seus gestores para correr mais riscos. A originalidade surge do fato de usar a tributação da DVA para análise do incentivo a remuneração.
Risk indentification on superheater pipeline boiler of 600 MW power plants using a risk based inspection (RBI) method
Authors: Rahman Okky Helja Octora Syahida , Pratama Fikri Wahyu , Siradj Eddy S 
Published: February 2023

Steam power plants are the most efficient type of power generation and can make a significant contribution to the demand for electricity resources. Steam power plants, in general, utilize energy derived from seawater to be process into steam in boilers so that often many pipe failures have occurred due to thinning due to corrosion caused by inappropriate water quality in small units and difficult to detect continuously. In general, inspection planning related to pipe thinning in steam power plants shows a minimal trend compared to inspections in the oil & gas industry. Moreover, it has no basic policy as to how inspection intervals and piping methods will be carry out. In this study, it carried out with the aim of conducting a risk assessment of boiler pipe failure so that it can provide a more optimal overview of the inspection plan. Analysis using Risk Based Inspection (RBI) will be used as a research reference to create the most effective and efficient inspection system as to minimize the impact and expenses cost in pipeline maintenance. After RBI assessment, the inspection plan for superheater pipeline on boiler line will be held every 2 years.
Improving Integrity in Research and Higher Education: An Indonesian Perspective [Meningkatkan Integritas Dalam Riset dan Pendidikan Tinggi: Sebuah Perspektif Indonesia]
Authors: Kozok Ulrich , Siaputra Ide Bagus 
Published: February 2023

Students and lecturers have challenges in publishing the results of their researches and studies as a requirement for graduation, promotion, or performance evaluation for institutions. This can bring up a variety of behaviors in producing scientific papers, ranging from those that should be emulated, questioned, doubtful, to being considered violations. The Indonesian government has issued regulations on academic integrity in producing scientific papers, but there are still new challenges such as misinformation and the use of artificial intelligence. Therefore, there is a need for indicators received together about the level of reasonableness in producing scientific work. This indicator must be relevant globally and accommodative to the local context. To strive for this, it is important to strive for dialogue between the academic community and the government to review publication policies and ensure that the regulations are effective and adaptive to the times and technological progress.

Mahasiswa dan dosen memiliki tantangan dalam mempublikasikan hasil penelitian dan studi mereka sebagai syarat kelulusan, kenaikan jabatan, atau evaluasi kinerja bagi lembaga. Hal ini dapat memunculkan beragam perilaku dalam menghasilkan karya ilmiah, mulai dari yang patut dicontoh, dipertanyakan, meragukan, hingga dianggap pelanggaran. Pemerintah Indonesia sudah menerbitkan peraturan tentang integritas akademik dalam menghasilkan karya ilmiah, namun masih ada tantangan baru seperti misinformasi dan penggunaan kecerdasan buatan. Maka dari itu, perlu ada indikator yang diterima bersama tentang tingkat kewajaran dalam menghasilkan karya ilmiah. Indikator ini harus relevan secara global dan akomodatif dengan konteks lokal. Untuk mengupayakan hal tersebut, penting untuk mengupayakan dialog antara sivitas akademika dan pemerintah untuk meninjau kembali kebijakan publikasi dan memastikan bahwa peraturan tersebut efektif dan adaptif terhadap perkembangan zaman dan kemajuan teknologi.
La mejora de la enseñanza y el aprendizaje en la universidad
Authors: Porlán Ariza Rafael 
Published: February 2023

Se presenta la reseña de tres obras cuyo nexo radica en cómo la Universidad de Sevilla ha venido aplicando durante 9 años el Programa FIDOP (Formación, Innovación e Investigación Docente del Profesorado) (https://institucional.us.es/fidopus/), orientado hacia una enseñanza centrada en el estudiante y el aprendizaje y basado en Ciclos de Mejora en el Aula.
Stent embolization in stented segment: a diagnostic challenge
Authors: Shroff Jenish , Lalani Kanhai , Parikh Pankti 
Published: February 2023

Abstract
Stent dislodgement during angioplasty is a rare but potentially fatal complication if not properly managed. We described a case of an elderly man who had previously undergone coronary angioplasty and now presented with an inferior wall myocardial infarction and required emergency angioplasty. Because of the loss of antegrade flow during the procedure, the proximal lesion was stented first. Undeployed stent was dislodged into proximal stent during distal stent deployment through proximal stent. This complication was addressed by crushing the undeployed stent and deploying another stent to secure the crushed stent to the arterial wall. Postprocedure patient was stable and discharged after 2 days. An operator should be aware of this risk as well as possible bailout options.
Analogous Mode Implementation of State Space Based Control of Buck Converter
Authors: Cucoș Diana-Elena , Neacșu Dorin O. 
Published: February 2023

Abstract
The new requirements for point-of-load converters include the dynamic behavior, leading to the need for improvements in the control system for the conventional buck converter. Usually, the regulator design, in order to secure stability at parameter or mode variation, aims a zero steady-state error and a phase margin over 60 degrees. The design based on Venable’s K-factor method (Venable, 1983) helps achieve this topic. A more modern control design method based on State Space is used progressively on digital platforms. This paper extends the merits of the State Space based design procedure with an analogous mode implementation.
The Biological Monitoring as a Source of Information on Environmental Pollution with Heavy Metals
Authors: Wacławek Maria , Świsłowski Paweł , Rajfur Małgorzata 
Published: February 2023

Abstract
The influence of environmental pollution on living organisms has been known for a long time, but it was not until the second half of the twentieth century that methodical studies on the influence of anthropopressure on changes in ecosystems began. Living organisms began to be used as biological indicators of environmental pollution. Cyclical and quantitative studies of pollutant concentrations in bioaccumulators have become the basis of modern biological monitoring (biomonitoring) of environmental pollution. Biomonitoring studies are carried out with the passive method (passive biomonitoring), in which living organisms occurring in their natural environment are analysed, and with active methods (active biomonitoring), in which, for example, plants living in the environment with low pollution are transferred and displayed in more polluted ecosystems e.g. heavy metals. The analysis of trace elements, including heavy metals accumulated in algae, mosses and lichens used in biological monitoring provides a lot of information on, among others concentration and origin of pollutants and the directions of their spread. Biomonitoring is used to assess the level of contamination of selected ecosystems, as well as the impact of individual emitters on the environment. An important element in determining the concentrations of trace elements in biological material used in biomonitoring is the proper planning of the experiment, taking into account, among others: methods of collecting or exposing samples, selection of analytical methods and methods of evaluation and interpretation of results. The aim of the presented long-term research, conducted by the Research Team of the Institute of Biology of the University of Opole, was to show that analytical techniques using biota samples can provide reliable data on the past, present and future state of the environment. However, it should be remembered that in order for the results of biomonitoring studies to be reliable and comparable, the applied research methodologies should be consistent and repeatable. In the presented research, Palmaria palmata and Spirogyra sp. algae, Pleurozium schreberi mosses, Hypogymnia physodes and bark of deciduous trees were used. In samples of biological material by the method of atomic absorption spectrometry, the concentrations of heavy metals, including Ni, Cu, Zn, Cd and Pb, were determined. On the basis of the conducted research, it was unequivocally stated that the biomonitoring methods are a good complement to the classic methods of environmental quality assessment. The analysis of the elements accumulated in the biological material provides us with information about the quality of the examined ecosystems, the introduced pollutants and their potential sources. This information allows for the introduction of effective measures to improve the quality of the environment.
Environmental Emissions Dispersion Modelling, Principles and Algorithms; Cross-Border CZ-PL Course for Master’s Students
Authors: Štěpánek Vladimír , Kříž Jan , Hyšplerová Lidmila , Keder Josef , Ziembik Zbigniew , Lyčka Antonín 
Published: February 2023

Abstract
Regular mathematical modelling of the dispersion of emissions from large sources is required by law in all EU countries. It is also used in risk analysis to predict releases of toxic substances from various technologies, from volcanic activity and possibly also terrorist acts. However, there is a shortage of experts in this very specific and demanding profession in the labour market in most EU countries. In a collaboration between academicians from neighbouring University of Hradec Králové and University of Opole and experts from important ecological companies of both regions we designed and verified as a part of a four-year pedagogical project supported by the EU a comprehensive education system in mathematical modelling of emission dispersion with exchange field trips and internships of students during cross-border Polish-Czech university education. The paper consists of two separate parts. The first part is focused on implementation of innovative lesson “Principles, algorithms, and differences of environmental dispersion emissions models”, used on both sides of Polish-Czech border region. An example of the use of the educational package of the Gaussian plume model with PC Templates, who was modified in cooperation between teachers from both cross-border universities and experts from professional companies is presented here too. Our four-year experience with student motivational field trips to professional companies in both border regions and exchange one-month professional internships for interested students to two Czech professional companies, where students learn to work with to the Gaussian plume model and one Polish professional company, where students are introduced to the Gaussian puff model is also discussed. The following separate second part will be focused on the innovative lesson of multivariate statistical methods of environmental data analysis, which are required for processing materials for modern mathematical modelling of the dispersion of emissions in practice. The target users of this two-part innovative courses are students of the MSc degree in Physical Measurement and Modelling at the University of Hradec Králové and students of the MSc degree in environmental studies at the University of Opole. However, it is also open to other Czech and foreign students and professionals.