bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analyzing the changing trend of corneal biomechanical properties under different influencing factors in T2DM patients
Authors: Li Tao , Lin Zhiwu , Tang Juan , Li Ying , Liu Xingde , Li Biao , Wu Xiaoli , Fang Qilin , Dai Chuanqiang , Lv Jing , Liu Guogang 
Published: April 2023

Abstract
Objective To analyze the changing trend of corneal hysteresis (CH) and corneal resistance factor (CRF) values under different influencing factors in T2DM patients.Purpose All patients underwent the ophthalmoscopy and fundus nuorescein angiography(FFA). A total of 650 patients with T2DM visited The First People’s Hospital of Ziyang from February 2022 to March 2023 were included. Logistic linear regression analysis was used to evaluate the independent risk factors of gender, age, course of T2DM, hypertension, smoking, drinking, BMI, systolic blood pressure(SBP) and diastolic blood pressure(DBP), fasting blood glucose(FBG), cholesterol(TC), triglycerides(TG), high-density lipoprotein cholesterol(HDL-C), low-density lipoprotein cholesterol (LDL-C) and hemoglobin (Hb)A1c related with T2DM. At the same time, according to the course of T2DM, FBG, DR stage, HbA1c (%) and other different pathological changes, the CH and CRF values were measured by the ocular response analyzer (ORA), and the change trend of their values was analyzed.Results In this study, we discovered that the course of T2DM, smoking history, BMI, FBG, DR, HbA1c, TC, TG, LDL-C were common risk factors for T2DM, while HDL-C was a protective factor, with statistically significant differences (P < 0.05). With the prolongation of T2DM, the increase of FBG, and the accumulation of HbA1C, the values of CH and CRF gradually decreased, especially in HbA1c (%) > 12, the values of CH (1.85 ± 0.33)mmHg and CRF(1.28 ± 0.69)mmHg decreased the most. Compared with the Non-DR group, the CH and CRF values gradually decreased in the mild-NPDR, moderate-NPDR, severe-NPDR and PDR groups, with the lowest CH and CRF values in the PDR group. Analysis of variance between groups showed statistically significant differences in CH and CRF values (P < 0.05).Conclusion In patients with T2DM, early measurement of corneal biomechanical properties by ORA so as to evaluate the change trend of CH and CRF values in different situations will help to identify and prevent diabetic keratopathy as soon as possible.
A comprehensive preimplantation genetic testing approach for SEA-type α-thalassemia by fluorescent Gap-polymerase chain reaction combined with haplotype analysis
Authors: Wang Jing , Ma Yuanlin , Guo Jing , Li Rong , Zhou Canquan , Xu Yanwen 
Published: April 2023

Abstract
Purpose This study aims to evaluate the feasibility and necessity of using fluorescence Gap-polymerase chain reaction (PCR) combined with haplotype analysis in preimplantation genetic testing (PGT) for SEA-type α-thalassemia.Methods Twenty-six PGT biopsy cycles were performed in 25 families from June 2021 to February 2022. All couples were carriers of the SEA-type α-thalassemia. Fluorescent Gap-PCR was employed for fragment deletion detection. Subsequently, according to the PCR results, reference embryos were identified to establish haplotype using single nucleotide polymorphic (SNP) array, while aneuploidy was screened simultaneously. In the cases that PCR results were inconsistent with the haplotype results, the reasons were investigated, either by re-test of the biopsied samples or re-biopsy of the embryo.Results Among 172 embryos, 162 had a consistent result tested by both methods, leading to a consistency rate of 94.2%. Ten embryos had inconsistent results, which were mainly due to chromosome 16 aneuploidy (n = 7), allele drop-out (ADO) in Gap-PCR (n = 2), or incorrectly haplotype due to poor sample amplification quality (n = 1). Clinical pregnancy rate of each frozen-thawed embryo transfer (FET) was 57.7% (15/26). Six families underwent prenatal diagnosis, which confirmed the PGT results.Conclusions Fluorescent Gap-PCR combined with haplotype analysis is feasible and necessary for SEA-type α-thalassemia PGT.
Evaluation of medicaments and final irrigating strategies on resin cement penetration and the bond strength of prefabricated fiber posts in oval-shaped root canals
Authors: Dewi Anat , Sastraruji Thanapat , Piangsuk Tarin , Louwakul Phumisak 
Published: April 2023

Abstract
Objectives: The purpose of this study was to evaluate the effect of different medicaments and root canal irrigation technique on dentinal tubule penetration of the resin cement and push-out bond strength of fiber post cemented with self-adhesiveresin cement.
Materials and Methods: Ninety mandibular premolars were mechanically instrumented until the apical size matches ISO 40. The specimens were divided into three groups based on medicaments; control (no medication), calcium hydroxide (CH), and triple antibiotic paste (TAP). The medicated groups were subdivided into 4 groups according to final irrigation techniques including conventional needle irrigation (CNI), sonic (SI), ultrasonic (PUI), and XP-endo finisher (XP). The specimens were cemented with RelyX U200 self-adhesive resin cement and were cross-sectioned to observe dentinal tubule penetration using confocal laser scanning microscope and perform push-out bond strength tests. The statistical evaluation was performed using One-Way ANOVA and Duncan’s post hoc test.
Results: The CNI group showed significantly lower levels of penetrated resin cement and bond strength compared to the control group in both CH and TAP groups (p < 0.05). No significant differences were observed when ultrasonic and XP-endo finisher were used for root canal irrigation (p > 0.05).
Conclusions: Medicaments can decrease the bond strength and penetration of resin cement into the dentinal tubules. Using agitated irrigation methods during final irrigation can enhance the cement adhesion and penetration.
Clinical Relevance: Agitated irrigation methods such as PUI and XP can improve resin cement adhesion after medication.
Changes in the femoral trochlear induced with estradiol exposure, an experimental study on rats
Authors: Wu Yu , Zhou Jin , Li Yanjun , Yu Hetong , Li Weifeng , Guo Pengfei , Han Zitao , Guo Lan , Ma Zhanbei 
Published: April 2023

Abstract
Background: It is well known that estrogen is closely related to bone and joint tissue. Findings indicate that estradiol, injected during pregnancy, passes through the placental barrier and reaches the fetuses in utero where it exerts its action. Since trochlea appears well established in the prenatal period, however, whether trochlear dysplasia is related to estradiol exposure has not been confirmed, and the pathological process of estradiol exposure-induced trochlear dysplasia remains unclear. This study aimed to establish an estradiol exposure animal model in fetuses and to analyze the morphology of the femoral trochlear in neonatal rats.
Methods: 30 pregnant Wistar rats provided by the local Animal Center
were assigned randomly into 3 groups, a high dose estradiol injection group, a low dose estradiol injection group and a blank control group. The pregnant rats in high dose group were intramuscular injected with estradiol benzoate, 200 μg/kg body weight, intramuscularly injected until the neonatal rats were born, and low dose group with 100 μg/kg body weight. Gross, cross-sectional observation and histological staining measurement of the rat offspring were conducted to evaluate the morphological changes of the femoral trochlea.
Results: The incidence of trochlear dysplasia increased with the concentration of estradiol injection. Neonatal rats in the high dose group had the high prevalence of trochlea dysplasia (53 of 60), followed by low dose of trochlea dysplasia (49 of 60). Gross and cross-sectional observation showed a shallower trochlea groove in two groups with estradiol injection. Histological staining measurement indicated that the trochlear sulcus angle and trochlear sulcus depth were significantly different between the two groups with estradiol injection and the blank control group at 0,5 and 10 days after birth.
Conclusion: In this study, estradiol exposure in fetuses had an adverse effect on intrauterine development and could induce trochlear dysplasia in rat offspring. In addition, this study also showed that the higher concentration of estradiol injection in pregnant rats, the more incidence of trochlear dysplasia in rat offspring.
Cluster Analysis Revealed Antibiotics with the Highest Efficacy Against Bacteria Isolated from Patients with Infectious and Inflammatory Diseases of the Soft Tissues of the Facial Area
Authors: Faustova Mariia , Nazarchuk Oleksandr , Loban' Galina , Ananieva Maiia , Chumak Yuliia , Lokes Kateryna , Avetikov Davyd 
Published: April 2023

Abstract
Incorrect prescription of antibiotics in dental surgery leads to acquisition of drug resistance by microorganisms. The aim of the given study was to conduct a retrospective cluster analysis of antibacterial drugs according to their efficacy against bacteria isolated from patients with infectious inflammatory diseases of the facial soft tissue. The cross-sectional study involved 351 patients who were treated for in the department of maxillofacial surgery during 2019-2022. According to the results of cluster analysis, clinical isolates of S. aureus isolated from foci of infectious and inflammatory diseases of the facial soft tissue retain sensitivity to moxifloxacin, vancomycin, ciprofloxacin, levofloxacin, norfloxacin and cefoxitin. Coagulase-negative Staphylococcus spp. are most sensitive to norfloxacin, erythromycin, benzylpenicillin, kanamycin, clindamycin, gentamicin and azithromycin, and Enterococcus ssp. to norfloxacin and tigecycline. The genus Kocuria and viridans streptococci group isolates retained a stable sensitivity only to vancomycin in a retrospective analysis.
Snakins: Antimicrobial potential and prospects of genetic engineering for enhanced disease resistance in plants
Authors: Iqbal Aneela , Khan Raham Sher 
Published: April 2023

Abstract
Snakins of the Snakin/GASA family are short sequenced peptides consisting of three different regions: a C-terminal GASA domain, an N-terminal signal sequence and a variable region. The GASA domain is comprised of 12 conserved cysteine ​​residues responsible for the structural stability of the peptide. Snakins are playing a variety of roles in response to various biotic stresses such as bacterial, fungal, and nematodes infections and abiotic stress like water scarcity, saline condition, and ROS. These properties make snakins very effective biotechnological tools for possible therapeutic and agricultural applications. This review was attempted to highlight and summarize the antifungal and antibacterial potential of snakins, also emphasizing their sequence characteristics, distributions, expression patterns and biological activities. In addition, further details of transgene expression in various plant species for enhanced fungal and bacterial resistance is also discussed, with special emphasis on their potential applications in crop protection and combating plant pathogens.
Findings of a Videofluoroscopic Swallowing Study in Patients with Dysphagia
Authors: Cui Qingjia , Wei Bing , He Yuan , Zhang Qian , Jia Weiwei , Wang Haiying , Xi Jianing , Dai Xin 
Published: April 2023

Abstract
Swallowing examination is crucial in patients with dysphagia. We aimed to compare qualitative and quantitative videofluoroscopic swallowing study (VFSS) results to provide reference for standardizing quantitative parameters. In total, 117 patients with dysphagia were included, 38 with Parkinson's disease and 39 and 40 in convalescence following cerebral hemorrhage and infarction. VFSS was both qualitatively and quantitatively analyzed. Oral transit time differed between oral motor function grades (P < 0.001), swallowing reaction times differed between swallowing reaction duration grades (P < 0.001), and soft palate lift duration differed between the soft palate lift grades (P < 0.001). Superior hyoid bone movement (P < 0.001), anterior hyoid bone movement (P < 0.001), hyoid pause time (P < 0.001), and hyoid movement duration (P = 0.032) differed between the hyoid laryngeal complex movement grades, as did the pharyngeal cavity transit time among the cricopharyngeal muscle opening duration grades (P < 0.001). The laryngeal vestibule closure duration differed among the glottic closure grades (P < 0.001). No statistically significant difference in upper esophageal sphincter opening diameter (P = 0.682) or duration (P = 0.682) among the cyclopharyngeal muscle opening duration grades. The pharyngeal area at rest did not significantly differ among the different vallecular residue (P = 0.202) and pyriform sinus residue (P = 0.116) grades. The quantitative results positively correlated with qualitative. Further optimization of parameters is recommended.
Comparison of Global Decolonization Efficacy with Mupirocin Nasal Drop and Chlorhexidine Mouthwash in Acute Leukemia Patients: Randomized Clinical Trial
Authors: Ghaffary Saba , Javidnia Aref , Beheshtirouy Samineh , Sadeghi Javid , Akbari Aliakbar Movassaghpour , Hamishehkar Hamed , Sarbakhsh Parvin , Sanaat Zohreh , Nikanfar Alireza , Esfahani Ali , Chavoshi Seyed Hadi , Nejati Babak , Raeisi Mortaza , Gholami Nasrin 
Published: April 2023

Abstract
Purpose
Neutropenic fever remains a major complication in acute leukemia. Decolonization is assumed as a promising intervention for eradicating causative agents of infection
Methods
In this randomized clinical trial, 96 patients with acute leukemia were assigned randomly to mupirocin nasal drop 2% (n = 32), chlorhexidine mouthwash 0.2% (n = 33), and control group (n = 31). In control group patients did not receive any medication for decolonization. All patients received treatment for 5 days (2 days prior to chemotherapy until 3 days after chemotherapy). Pharynx and nasal swabs were taken prior to the intervention and at the end of decolonization period in all groups. Antibiotic susceptibility testing was performed by the disc diffusion method in order to identify bacterial isolates.
Results
Bacterial recovery of both nasal and pharynx swabs was observed after global decolonization with mupirocin nasal drop. Decolonization with mupirocin significantly eradicated Coagulase-negative staphylococci (CONS) in both nasal and pharynx swabs (p-value = 0.000). Moreover, mupirocin decreased pseudomonas aeruginosa and methicillin-resistant Staphylococcus aureus (MRSA) species. Chlorhexidine mouthwash significantly eradicated CONS in pharynx swabs (p-value = 0.000). In addition, both decolonization strategies decreased both antibiotic use and frequency of fever in leukemic patients.
Conclusion
Global decolonization with mupirocin nasal drop not only eradicates both nasal and pharynx microorganisms, but also reduces antibiotic requirement and frequency of fever in patients with acute leukemia.
The protocol of the present study was approved on December 2016 (registry number: IRCT20160310026998N6).
Diurnal shelf waves in the area of the South Kuril Islands from the TOPEX/Poseidon satellite altimetry data
Authors: Shevchenko Georgy , Tsoi Alexander 
Published: April 2023

Abstract
The existence zones of diurnal shelf waves near the South Kuril Islands were determined based on the analysis of small-scale amplitude and phase variations of diurnal O1 and K1 tidal waves estimated from along-track TOPEX/Poseidon altimetry data. The amplitudes and phases of the these waves were revealed not only along the original tracks (1992–2002), but also along those shifted by half the intertrack distance (2002–2005). This made it possible to more accurately determine the zone of existence of diurnal shelf waves. It was found that these waves, existing in the form of baroclinic coastal trapped modes, strongly influence tidal motions on the oceanic shelf of Urup and Iturup islands. Two wavelengths fit in this section of the shelf (one pair of quasi-stationary eddies is localized on the shelf of Urup Island and the second one on the shelf of Iturup Island). This is an unexpected and interesting result; barotropic shelf modes usually form one pair of eddies (for example, on the northeaster shelf of Sakhalin Island, on the northern shelf of Hokkaido Island and on the oceanic shelf of the North Kuril Islands). We found that the zone of influence of both K1 and O1 tidal waves starting from Chirpoi Island, which means that shelf waves are generated as a result of the diffraction of a large-scale Kelvin tidal wave on the deep Bussol Strait. The existence of lower frequency O1 tidal shelf wave was found not only on the shelf of Urup and Iturup islands, but also on the shelf of Shikotan Island, which is consistent with the earlier results of Yefimov and Rabinovich (1980). Diurnal shelf waves cause significant increase of O1 and K1 amplitudes on the coast of Iturup Island (especially in its southern part) and Urup Island in comparison with the open ocean and produce strong diurnal tidal currents in these regions, as it follows from the direct instrumental. Baroclinic diurnal shelf (coastal trapped) waves are also the reason of vertical movements, forcing water temperature variations at sufficiently great depths, which can have a significant impact on the living conditions of benthic communities.
Smart Manufacturing: Enhancing Efficiency and Quality with Intelligent Computers
Authors: Ihar yeuseyenka 
Published: April 2023

Abstract
CIM is a manufacturing approach that provides a complete automation process to manufacturing industries for efficient and quality production. During the production process, all of the 2 operations are controlled by computers and distributed through a centralized server. The various 3 processes involved in a CIM include prototype designing, product manufacturing, and many complex 4 operations from a single bolt to heavy vehicular engines. CIM combines applications and technologies like CAD, CAM, robotics, manufacturing resource planning, and enterprise management solutions. It can also be considered an integration of all enterprise operations with a common data repository. There exist integrated manufacturing systems, and various approaches are explained in this research article step by step. The issues and challenges exist with the current framework are highlighted, and the solution is provided. The novelty of the proposed research is the use of industry 4.0 technology technologies for simulating industrial processes (overlaying virtual 2D and 3D images on real objects and using holograms to display the HMI (Human Machinery Interface) and virtual equipment. The proposed development methodology allows the integration of Mixed Reality (holograms) with the IoT/SCADA systems. It provides the user with remote control and monitoring of training equipment worldwide through HMIs, including surveillance cameras and holographic dashboards. Apart from 15 graphical and tabular ways of measured and calculated data representation, interactive 3D visualization and animation of training equipment elements are supported. The main purpose of this research paper is to explore the application of intelligent CIM and identify the issues related to CIM. Moreover, the use and integration of intelligent tools and their impact are explored in this research article which 19 can provide the option to the industries manager to choose the best tools and CIM technologies for wider applications.
Unusual Homogenous Dual Permeation Feeding In Squeeze Casting To Produce Quality Composites for Marine Applications
Authors: PANDIAN C. K. ARVINDA , MANIVANNAN A. , BALAMURUGAN R. , Sasikumar R 
Published: April 2023

Abstract
This research effort seeks to examine corrosion, tribological, and mechanical properties of Enhanced Composites made of Aluminium Matrix produced using a new blended dual permeation feeding in squeeze casting route. Squeeze casting's key problems are conglomeration and non-uniform diffusion of reinforcing particles that also ultimately resulted in poor quality composites. This could hinder the composite's effectiveness on key target properties. To mitigate this, an innovative blended feeding was initially attempted to accomplish homogenous distribution, which was successful with subsequent attempts. To produce improved aluminium composite materials with different volume fractions (0%, 3%, 6%, and 9%), AA 6061 was used as the metal matrix and Nano molybdenum disulfide (MoS2) as the reinforcement companion. The high-quality composites have been manufactured for identification using various tests like SEM, EDAX, and Salt Spray.
Prognostic factors of disease-free survival in patients with breast cancer
Authors: Chen Chia-Chi , Tang Wei-Hua , Wu Cheng-Ching , Lee Thung-Lip , Tsai I-Ting , Hsuan Chin-Feng , Hung Wei-Chin , Chung Fu-Mei , Lee Yau-Jiunn , Yu Teng-Hung , Wei Ching-Ting 
Published: April 2023

AbstractBackgroundBreast cancer is the second most common malignancy globally and a leading cause of cancer death in women. Analysis of factors related to disease-free survival (DFS) has improved understanding of the disease and characteristics related to recurrence. The aim of this study was to investigate the predictors of DFS in patients with breast cancer to enable the identification of patients at high risk who may benefit from prevention interventions.MethodsWe retrospectively analyzed 559 women with breast cancer who underwent treatment between 2004 and 2022. The study endpoint was DFS (including local recurrence, regional recurrence, secondary breast cancer, or death from any cause). Baseline tumor-related characteristics, treatment-related characteristics, sociodemographic and biochemical data were analyzed using Cox proportional hazards analysis and receiving operating characteristic curves. The median DFS was 45 months (range, 2 to 225 months).ResultsBreast cancer recurred in 86 patients (15.4%). Regression analysis showed that age, body mass index, surgery type, T3-T4 clinical tumor stage, tumor grade 3, American Joint Committee on Cancer (AJCC) stage III, Ki67 ≥ 14%, estrogen receptor-negative, progesterone receptor-negative, chemotherapy, carcinoembryonic antigen, CA153, red cell distribution width (RDW)-standard deviation (SD), aspartate aminotransferase, estimated glomerular filtration rate, albumin, hemoglobin, RDW-coefficient of variation, and platelet, white blood cell, neutrophil and monocyte count were associated with DFS. Multivariate Cox regression analysis showed that AJCC stage III, Ki67 ≥ 14%, albumin, platelet, and RDW-SD were independently associated with DFS. Furthermore, Kaplan-Meier analysis showed that albumin ≤ 4.1 g/dl, platelet ≥ 253 10^3/µl, RDW-SD ≥ 44 fL were significantly reduced DFS in patients with breast cancer.ConclusionsIn addition to the traditional prognostic factors such as AJCC stage III and Ki67 ≥ 14%, preoperative a cutoff albumin value of ≤ 4.1 g/dl, a cutoff platelet value of ≥ 253 10^3/µl, and a cutoff RDW-SD value of ≥ 44 fL could significantly predict DFS in patients with breast cancer.