bluuebunny/crossref_metadata_2025_split huggingface dataset:
Circadian Rest–Activity Rhythms, Delirium Risk, and Progression to Dementia
Authors: Gao Lei , Li Peng , Gaykova Nicole , Zheng Xi , Gao Chenlu , Lane Jacqueline M. , Saxena Richa , Scheer Frank A. J. L. , Rutter Martin K. , Akeju Oluwaseun , Hu Kun 
Published: February 2023

ObjectiveDelirium is a complex neurocognitive syndrome suspected to be bidirectionally linked to dementia. Circadian rhythm disturbances likely contribute to dementia pathogenesis, but whether these disturbances are related to delirium risk and progression to all‐cause dementia is unknown.MethodsWe analyzed continuous actigraphy data from 53,417 middle‐aged or older UK Biobank participants during a median 5 years of follow‐up. Four measures were used to characterize the 24‐hour daily rest–activity rhythms (RARs): normalized amplitude, acrophase representing the peak activity time, interdaily stability, and intradaily variability (IV) for fragmentation of the rhythm. Cox proportional hazards models examined whether RARs predicted incident delirium (n = 551) and progression to dementia (n = 61).ResultsSuppressed 24‐hour amplitude, lowest (Q1) versus highest (Q4) quartile (hazard ratio [HR]Q1 vs Q4= 1.94, 95% confidence interval [CI] = 1.53–2.46,p < 0.001), and more fragmented (higher IV: HRQ4 vs Q1= 1.49, 95% CI = 1.18–1.88,p < 0.001) rhythms predicted higher delirium risk, after adjusting for age, sex, education, cognitive performance, sleep duration/disturbances, and comorbidities. In those free from dementia, each hour of delayed acrophase was associated with delirium risk (HR = 1.13, 95% CI = 1.04–1.23,p = 0.003). Suppressed 24‐hour amplitude was associated with increased risk of progression from delirium to new onset dementia (HR = 1.31, 95% CI = 1.03–1.67,p = 0.03 for each 1‐standard deviation decrease).InterpretationTwenty‐four‐hour daily RAR suppression, fragmentation, and potentially delayed acrophase were associated with delirium risk. Subsequent progression to dementia was more likely in delirium cases with suppressed rhythms. The presence of RAR disturbances before delirium and prior to progression to dementia suggests that these disturbances may predict higher risk and be involved in early disease pathogenesis. ANN NEUROL 2023;93:1145–1157
Incidence of Orofacial Manifestations of Juvenile Idiopathic Arthritis From Diagnosis to Adult Care Transition: A Population‐Based Cohort Study
Authors: Glerup Mia , Tagkli Aikaterini , Küseler Annelise , Christensen Anne E. , Verna Carlalberta , Bilgrau Anders E. , Nørholt Sven Erik , Herlin Troels , Pedersen Thomas K. , Stoustrup Peter 
Published: February 2023

ObjectiveTo estimate the cumulative incidences of orofacial conditions related to temporomandibular joint (TMJ) juvenile idiopathic arthritis (JIA) between diagnosis in childhood to transition into adult care, and to identify features in JIA associated with TMJ involvement.MethodsA population‐based cohort analysis was conducted of patients with JIA involving longitudinal data on orofacial health from 2000 to 2018. Regardless of TMJ status, the patients were referred to the Regional Specialist Craniofacial Clinic of Western Denmark for routine orofacial examinations. Data collection included information about disease‐specific background characteristics, TMJ involvement, JIA‐induced dentofacial deformity, and orofacial symptoms and dysfunction.ResultsA total of 613 patients were followed up with a mean clinical TMJ observation time of 4.0 years. From JIA onset to transition into adult care, the cumulative incidence of patients with JIA involvement of the TMJ was 30.1%. Furthermore, 20.6% of the cohort had developed arthritis‐induced dentofacial deformity. A substantial proportion of the cohort experienced several events with orofacial symptoms (23.5%) and dentofacial dysfunction (52%). Young age at diagnosis (<9 years), female gender, and antinuclear antibody positivity were significantly associated with TMJ involvement.ConclusionOrofacial signs and symptoms were frequent findings in children and adolescents with JIA. TMJ involvement was seen in 30.1% of the cohort; and 20.6% of the total cohort developed JIA‐related dentofacial deformity before transition into adult care. This is the first population‐based study in the era of available biologic treatments to document these frequent orofacial complications in children with JIA.
Flexible Gel Polymer Electrolytes Based on Carboxymethyl Cellulose Blended with Polyvinyl Alcohol or Polyacrylic Acid for Zinc‐Air Batteries
Authors: García‐Gaitán Estibaliz , Frattini Domenico , Ruiz de Larramendi Idoia , Martínez‐Ibáñez María , González Daniel , Armand Michel , Ortiz‐Vitoriano Nagore 
Published: February 2023

AbstractFlexible zinc‐air batteries are based on gel polymer electrolytes (GPE), soft, semi‐solid components devoted to liquid electrolyte retention, ion conduction, and mechanical stability. Many synthetic polymers, and their blends, have been used in early works due to the good compromise between ionic conductivity, electrolyte retention, and mechanical resistance. Naturally occurring biopolymers are a great alternative to increase the sustainability of GPE, but present properties are not sufficient. In this work, the blending of carboxymethyl cellulose (CMC) with polyvinyl alcohol (PVA) or polyacrylic acid (PAA) is studied together with synthesis, cross‐linking, and liquid electrolyte embedding method. The CMC : PAA (1 : 2) composite, with ex‐situ gel embedding of 8 M KOH electrolyte achieved ionic conductivity of 0.231 S cm−1 at room temperature, high liquid electrolyte uptake and retention, providing a 78 % of zinc utilization and 443.19 Wh kg−1 as energy density for assembled primary zinc‐air battery. The CMC : PAA and CMC : PVA also showed unexpected self‐healing behavior activated by re‐wetting with liquid KOH solution and drying.
The sublingual branch of the lingual nerve: Anatomical study and suggestion for a new terminology
Authors: Iwanaga Joe , Jackson Neal , Toriumi Taku , Kageyama Ikuo , Reina Francisco , Carrera Ana , Fukino Keiko , Kitagawa Norio , Tubbs R. Shane 
Published: February 2023

AbstractThe lingual nerve carries somatosensory fibers from the anterior two‐thirds of tongue. The parasympathetic preganglionic fibers arising from the chorda tympani also travel with the lingual nerve in the infratemporal fossa to synapse in the submandibular ganglion to innervate the sublingual gland. However, only a few studies have investigated the specific nerve that innervates the sublingual gland and surrounding tissue i.e., the so‐called sublingual nerve. Therefore, this study aimed to clarify the anatomy and definition of the sublingual nerves. Thirty sides from formalin fixed cadaveric hemiheads underwent microsurgical dissection of the sublingual nerves. The sublingual nerves were found on all sides and categorized into three branches, i.e., branches to the sublingual gland, branches to the mucosa of the floor of the mouth, and gingival branches. Additionally, branches to the sublingual gland were subcategorized into types I and II based on the origin of the sublingual nerve. We suggest that the lingual nerve branches should be categorized into five branches, i.e., branches to the isthmus of the fauces, sublingual nerves, lingual branches, posterior branch to the submandibular ganglion, and branches to the sublingual ganglion.
Peripheral lymphocytes and lactate dehydrogenase correlate with response and survival in head and neck cancers treated with immune checkpoint inhibitors
Authors: Pan Cassie , Wu Qian Vicky , Voutsinas Jenna , Houlton Jeffrey J. , Barber Brittany , Rizvi Zain H. , Marchiano Emily , Futran Neal , Laramore George E. , Liao Jay J. , Parvathaneni Upendra , Martins Renato G. , Fromm Jonathan R. , Rodriguez Cristina P. 
Published: February 2023

AbstractBackgroundLittle is known regarding associations between peripheral blood biomarkers (PBBMs) and survival, response, and toxicity in recurrent/metastatic head and neck squamous cell carcinomas (R/M HNSCC) treated with immune checkpoint inhibitors (ICIs).MethodsIn this single‐institution retrospective cohort study, a dataset of patients with R/M HNSCC treated with ICIs between 08/2012–03/2021 was established, including demographic and clinicopathologic characteristics. Pretreatment PBBMs were collected and evaluated for associations with grade ≥3 adverse events (G ≥ 3AE) by CTCAEv5, objective response (ORR) by RECIST 1.1, overall survival (OS), and progression‐free survival (PFS). Multivariable models for each outcome were created using elastic net variable selection.ResultsOur study included 186 patients, with 51 (27%) demonstrating complete or partial response to immunotherapy. Multivariable models adjusted for ECOG performance status (PS), p16, and smoking demonstrated that pretreatment higher LDH and absolute neutrophils, as well as lower percent lymphocytes correlated with worse OS and PFS. Higher LDH and lower % lymphocytes also correlated with worse ORR.ConclusionsIn the largest study to date examining PBBMs in ICI‐treated R/M HNSCCs, our variable selection method revealed PBBMs prognostic for survival and response to immunotherapy. These biomarkers warrant further investigation in a prospective study along with validation with CPS biomarker.
Role of tumor microenvironment in cancer progression and therapeutic strategy
Authors: Wang Qingjing , Shao Xueting , Zhang Yuxuan , Zhu Miaojin , Wang Frederick X. C. , Mu Jianjian , Li Jiaxuan , Yao Hangping , Chen Keda 
Published: February 2023

AbstractCancer is now considered a tumor microenvironment (TME) disease, although it was originally thought to be a cell and gene expression disorder. Over the past 20 years, significant advances have been made in understanding the complexity of the TME and its impact on responses to various anticancer therapies, including immunotherapies. Cancer immunotherapy can recognize and kill cancer cells by regulating the body's immune system. It has achieved good therapeutic effects in various solid tumors and hematological malignancies. Recently, blocking of programmed death‐1 (PD‐1), programmed death‐1 ligand‐1 (PD‐L1), and programmed death Ligand‐2 (PD‐L2), the construction of antigen chimeric T cells (CAR‐T) and tumor vaccines have become popular immunotherapies Tumorigenesis, progression, and metastasis are closely related to TME. Therefore, we review the characteristics of various cells and molecules in the TME, the interaction between PD‐1 and TME, and promising cancer immunotherapy therapeutics.
Modeling and Control of Beer Fermentation for Optimal Flavor and Performance
Authors: Yerolla Raju , Nekkanti Sri Harsha , Pullanikkattil Suhailam , Besta Chandra Shekar 
Published: February 2023

AbstractBeer has been consumed for millennia and fermentation is crucial to the brewing process. The process requires bacteria, yeast, and carbohydrates. The temperature has the most significant influence on the beer quality as the fermentation temperature affects the fruitiness and acidity. In this work, a growth and a taste model are built for the beer fermentation process. The dynamic model simulation findings are compared and validated with industry data reported in the literature. The temperature must be regulated to maintain the consistency and flavor of the beer. The dynamic model determines the optimal controller settings for maximizing energy efficiency. To get the optimal taste profile, the proportional‐integral/proportional‐integral‐derivative controller is used to obtain optimal temperature control.
Recent Progress in Co3O4‐Based Nanomaterials for Supercapacitors
Authors: Lu Congcong , Liu Lingran , Yang Yu , Ma Yunping , Luo Qiao , Zhu Maiyong 
Published: February 2023

AbstractSupercapacitors which have been widely used in portable electronics and hybrid electric vehicles are considered to be fascinating energy storage devices owing to their higher energy density than traditional capacitors and higher power density than batteries. The performance of supercapacitors is much dependent on the properties of the used electrode materials, and much effort has been devoted to exploring high‐performance electrodes. During the past decade, cobalt‐based materials, especially Co3O4 and its composites, have been regarded as prominent electrode materials for supercapacitors in view of their relatively low cost, high theoretical specific capacitance, non‐toxicity, and excellent electrochemical activity. In this review, we attempt to provide some basic insights into the rational design of Co3O4 based materials/composites and their capacitive properties for supercapacitors. The electrochemical advantages of Co3O4 as a supercapacitor material are summarized, and many examples are illustrated. The remaining challenges in exploration of Co3O4‐based materials as efficient electrodes for supercapacitors are also discussed and the future research directions are offered.
Love's a dance you learn as you go: Evidence for interpersonal complementarity during romantic conflict and its association with relationship outcomes
Authors: Slotter Erica B. , Markey Patrick M. , Audigier Alexis , Dashineau Samantha C. , Finkel Eli J. , Luchies Laura B. 
Published: February 2023

AbstractHigh‐quality romantic bonds benefit people. Extant literature has explored many individual and relational factors that contribute to high‐quality relationships, yet research on how moment‐to‐moment behaviours predict quality is still in the nascent stages. The current study explored interpersonal complementarity on warmth and dominance as one index of moment‐to‐moment interaction dynamics in romantic relationships. The sample included 180 couples (360 individuals), examined at 10‐s intervals, over the course of an 8‐min conflict discussion. Analysis confirmed the predicted pattern of complementarity such that people adjusted their behaviours in response to their partner's behaviour, engaging in similar levels of warmth and opposite levels of dominance (Hypothesis 1). Additionally, results revealed that relationship length was logarithmically related to dominance complementarity, whereas it was not significantly related to warmth complementarity (Hypothesis 2). Finally, dominance and warmth complementarity were differentially associated with numerous relational constructs (Hypothesis 3a/3b).
Bio‐Graphene Sensors for Monitoring Moisture Levels in Wood and Ambient Environment
Authors: Mulla Mohammad Yusuf , Isacsson Patrik , Dobryden Illia , Beni Valerio , Östmark Emma , Håkansson Karl , Edberg Jesper 
Published: February 2023

AbstractWood is an inherently hygroscopic material which tends to absorb moisture from its surrounding. Moisture in wood is a determining factor for the quality of wood being employed in construction, since it causes weakening, deformation, rotting, and ultimately leading to failure of the structures resulting in costs to the economy, the environment, and to the safety of residents. Therefore, monitoring moisture in wood during the construction phase and after construction is vital for the future of smart and sustainable buildings. Employing bio‐based materials for the construction of electronics is one way to mitigate the environmental impact of such electronics. Herein, a bio‐graphene sensor for monitoring the moisture inside and around wooden surfaces is fabricated using laser‐induced graphitization of a lignin‐based ink precursor. The bio‐graphene sensors are used to measure humidity in the range of 10% up to 90% at 25 °C. Using laser induced graphitization, conductor resistivity of 18.6 Ω sq−1 is obtained for spruce wood and 57.1 Ω sq−1 for pine wood. The sensitivity of sensors fabricated on spruce and pine wood is 2.6 and 0.74 MΩ per % RH. Surface morphology and degree of graphitization are investigated using scanning electron microscopy, Raman spectroscopy, and thermogravimetric analysis methods.
Maternity care provision for women living with female genital mutilation/cutting: A qualitative study from a high asylum‐seeking dispersal context in the UK
Authors: Turner Jessica , Tancred Tara 
Published: February 2023

AbstractObjectiveTo explore the perspectives of midwives and obstetrician/gynaecologists providing maternity care to women living with female genital mutilation/cutting (FGM/C) in a high asylum‐seeker dispersal area in the North West of England.MethodsWe carried out a qualitative study in four hospitals providing maternal health services within the North West of England, with the highest population of asylum‐seeking individuals (many from high‐prevalence FGM/C countries) in the UK. Participants included 13 practicing midwives and an obstetrician/gynaecologist. In‐depth interviews were conducted with study participants. Data collection and analysis were carried out concurrently until theoretical saturation was reached. Data were analysed thematically to generate three key overarching themes.ResultsThere is a disconnect between Home Office dispersal policy and healthcare policy. Participants indicated that there was inconsistent identification or disclosure of FGM/C, constraining appropriate follow‐up and care prior to labour and childbirth. All participants noted existing safeguarding policies and protocols, which were seen by most as being important to protect female dependants, but potentially detrimental to the patient‐provider relationship and to the woman's care. Unique challenges around accessing and maintaining continuity of care for asylum‐seeking women due to dispersal schemes were indicated. All participants highlighted a lack of specialised training for FGM/C to support provision of clinically appropriate and culturally sensitive care.ConclusionsThere is a clear need for harmony between health and social policy as well as specialised training that centres holistic wellbeing for the woman living with FGM/C, particularly where there are increased numbers of asylum‐seeking women from high‐prevalence FGM/C countries.
Self‐care for coronavirus disease through electronic health technologies: A scoping review
Authors: Asadi Farkhondeh , Rahimi Fatemeh , Ghaderkhany Shady , Almasi Sohrab 
Published: February 2023

AbstractBackground and AimsConsidering the rapid spread and transmission of COVID‐19 and its high mortality rate, self‐care practices are of special importance during this pandemic to prevent and control the spread of the virus. In this regard, electronic health systems can play a major role in improving self‐care practices related to coronavirus disease. This study aimed to review the electronic health technologies used in each of the constituent elements of the self‐care (self‐care maintenance, self‐care monitoring, and self‐care management) during the COVID‐19 pandemic.MethodsThis scoping review was conducted based on Arksey and O'Malley's framework. In this study, the specific keywords related to “electronic health,” “self‐care,” and “COVID‐19” were searched on PubMed, Web of Science, Scopus, and Google.ResultsOf the 47 articles reviewed, most articles (27 articles) were about self‐care monitoring and aimed to monitor the vital signs of patients. The results showed that the use of electronic health tools mainly focuses on training in the control and prevention of coronavirus disease during this pandemic, in the field of self‐care maintenance, and medication management, communication, and consultation with healthcare providers, in the field of self‐care management. Moreover, the most commonly used electronic health technologies were mobile web applications, smart vital signs monitoring devices, and social networks, respectively.ConclusionThe study findings suggested that the use of electronic health technologies, such as mobile web applications and social networks, can effectively improve self‐care practices for coronavirus disease. In addition, such technologies can be applied by health policymakers and disease control and prevention centers to better manage the COVID‐19 pandemic.
Cell membrane biomimetic nanomedicines for cancer phototherapy
Authors: Chen Min , Sun Yun , Liu Huiyu 
Published: February 2023

AbstractPhototherapy, mainly including photothermal therapy (PTT) and photodynamic therapy (PDT), can kill cancer cells by generating heat or reactive oxygen species, which has the advantages of being minimally invasive, high efficiency, and low toxicity. However, traditional phototherapeutic agents face challenges such as poor tumor targeting, susceptibility to passive immune clearance, and suboptimal biocompatibility, which limit their clinical application. Recently, cell membrane biomimetic technology endows phototherapeutic agents with unique biological functions, such as promoted immune escape, prolonged in vivo circulation time, improved biocompatibility, and enhanced anti‐tumor efficacy. In addition, phototherapy mediated by cancer cell membrane (CCM) or immune cell membrane‐modified phototherapeutic agents can promote broad anti‐tumor immunity. In this review, we deeply analyze the mechanisms of PTT and PDT, systematically discuss the synthesis strategies and biological functions of cell membrane biomimetic nanomaterials, and focus on the progress of phototherapy based on biomimetic nanomaterials and synergistic therapies such as chemotherapy, radiotherapy, immunotherapy, and sonodynamic therapy. Finally, we address the opportunities and future prospects of biomimetic nanomaterials in the field of cancer phototherapy. This comprehensive review is expected to provide insights into promoting the clinical translation of biomimetic phototherapeutic agents.
Thirty years of partnerships to achieve sustainable irrigation through Shepparton Irrigation Region Land and Water Management Plan
Authors: Walters Carl , Bruce Kelvin , McFarlane Megan 
Published: February 2023

AbstractThe Shepparton Irrigation Region (SIR) is an environmentally and economically significant area in northern Victoria of Australia covering 500,000 ha. The 1990–2020 Shepparton Irrigation Region Land and Water Management Plan (SIRLWMP) was developed in the late 1980s due to community alarm around increasing salinity and groundwater tables. The regional community (with the support of government, farmers and technical experts) started implementing the plan in 1990. The plan was unique and innovative in Australia in its approach to taking a long‐term view of environmental sustainability. A long‐term and adaptive partnership approach across all levels was vital because environmental problems did not always become apparent in the short term. All of the partners involved in the plan learned to persist and adapt their approach to build resilience in the socio‐economic systems. The SIRLWMP has enabled many serious challenges to be successfully navigated and adapted to including extreme climate events, changing land use and community demographics. Each of these challenges required the ongoing collaboration of many partners to continuously improve the direction and achievements of the SIRLWMP. A 2020 review of the achievements of the 30 years of implementation showed the quantifiable breadth and depth of achievements against the plan's goals. However, there is still more work to do, and the SIRLWMP continues beyond 2020 in a challenging environment. It is expected that partners would continue to work together and continue to talk through difficult issues—because this is how real change happens.