bluuebunny/crossref_metadata_2025_split huggingface dataset:
Single‐cell RNA sequencing identifies macrophage signatures correlated with clinical features and tumour microenvironment in meningiomas
Authors: Zhang Xiaowei 
Published: July 2023

AbstractBackgroundMeningiomas are common primary brain tumours, with macrophages playing a crucial role in their development and progression. This study aims to identify module genes correlated with meningioma‐associated macrophages and analyse their correlation with clinical features and immune infiltration.MethodsWe analysed single‐cell RNA sequencing (scRNA‐seq) data from two paired meningioma and normal meninges to identify meningioma‐associated macrophages. High‐dimensional weighted gene co‐expression network analysis (hdWGCNA) was employed to identify module genes linked to these macrophages, followed by functional enrichment and pseudotime trajectory analyses. A machine learning‐based model using the module genes was developed to predict tumour grades. Finally, meningiomas were classified into two molecular subtypes based on the module genes, followed by a comparison of clinical characteristics and immune cell infiltration.ResultsMeningiomas exhibited a significantly higher proportion of macrophages than normal meninges, including novel macrophage clusters referred to as meningioma‐associated macrophages. The hdWGCNA analysis of macrophages within meningiomas unveiled 12 distinct modules, with the blue, black, and turquoise modules closely correlated with the meningioma‐associated macrophages. Hub genes within these modules were enriched in immune regulation, cellular communication, and metabolism pathways. Machine learning analysis identified 13 module genes (RSBN1, TIPRL, ATIC, SPP1, MALSU1, CDK1, MGP, DDIT3, SUPT16H, NFKBIA, SRSF5, ATXN2L, and UBB) strongly correlated with meningioma grade and constructed a predictive model with high accuracy and robustness. Based on the module genes, meningiomas were classified into two subtypes with distinct clinical and tumour microenvironment characteristics.ConclusionsOur findings provide insights into the molecular characteristics underlying macrophage infiltration in meningiomas. The molecular signatures of macrophages demonstrate correlations with clinical features and immune cell infiltration in meningiomas.
Radial distribution of giant exoplanets at Solar System scales
Authors: Lagrange A.-M. , Philipot F. , Rubini P. , Meunier N. , Kiefer F. , Kervella P. , Delorme P. , Beust H. 
Published: July 2023

Aims. Giant planets play a major role in multiple planetary systems. Knowing their demographics is important to test their overall impact on the formation of planetary systems. It is also important to test their formation processes. Recently, three radial velocity (RV) surveys have established radial distributions of giant planets. All show a steep increase up to 1–3 au, and two suggest a decrease beyond that.
Methods. We aim to understand the limitations associated with the characterization of long-period giant RV planets, and to estimate their impact on the radial distribution of these planets.
Results. We revisit the results obtained by two major surveys that derived such radial distributions, using the RV data available at the time of the surveys as well as, whenever possible, new data.
Conclusions. We show that the radial distributions published beyond (5–8 au) are not secure. More precisely, the decrease in the radial distribution beyond the peak at 1–3 au is not confirmed.
Use of endoscopic submucosal dissection or full-thickness resection device to treat residual colorectal neoplasia after endoscopic resection: a multicenter historical cohort study
Authors: Yzet Clara , Le Baleur Yann , Albouys Jérémie , Jacques Jérémie , Doumbe-Mandengue Paul , Barret Maximilien , Abou Ali Einas , Schaefer Marion , Chevaux Jean-Baptiste , Leblanc Sarah , Lepillez Vincent , Privat Jocelyn , Degand Thibault , Wallenhorst Timothée , Rivory Jérôme , Chaput Ulriikka , Berger Arthur , Aziz Karim , Rahmi Gabriel , Coron Emmanuel , Kull Eric , Caillo Ludovic , Vanbiervliet Geoffroy , Koch Stéphane , Subtil Fabien , Pioche Mathieu 
Published: August 2023

Introduction Residual colorectal neoplasia (RCN) after previous endoscopic mucosal resection is a frequent challenge. Different management techniques are feasible including endoscopic full-thickness resection using the full-thickness resection device (FTRD) system and endoscopic submucosal dissection (ESD). We aimed to compare the efficacy and safety of these two techniques for the treatment of such lesions.
Methods All consecutive patients with RCN treated either using the FTRD or by ESD were retrospectively included in this multicenter study. The primary outcome was the R0 resection rate, defined as an en bloc resection with histologically tumor-free lateral and deep margins.
Results 275 patients (median age 70 years; 160 men) who underwent 177 ESD and 98 FTRD procedures for RCN were included. R0 resection was achieved in 83.3 % and 77.6 % for ESD and FTRD, respectively (P = 0.25). Lesions treated by ESD were however larger than those treated by FTRD (P < 0.001). The R0 rates for lesions of 20–30 mm were 83.9 % and 57.1 % in the ESD and FTRD groups, respectively, and for lesions of 30–40 mm were 93.6 % and 33.3 %, respectively. On multivariable analysis, ESD procedures were associated with statistically higher en bloc and R0 resection rates after adjustment for lesion size (P = 0.02 and P < 0.001, respectively). The adverse event rate was higher in the ESD group (16.3 % vs. 5.1 %), mostly owing to intraoperative perforations.
Conclusion ESD is effective in achieving R0 resection for RCN whatever the size and location of the lesions. When residual lesions are smaller than 20 mm, the FTRD is an effective alternative.
Characterization and Usefulness of Clot-Fibrinolysis Waveform Analysis in Critical Care Patients with Enhanced or Suppressed Fibrinolysis
Authors: Tsuchida Takumi , Hayakawa Mineji , Kumano Osamu 
Published: August 2023

Introduction Recently, clot-fibrinolysis waveform analysis (CFWA), which is a coagulation and fibrinolysis global assay based on assessing the activated partial thromboplastin time with tissue-type plasminogen activator, was developed. This study aimed to investigate the characteristics of CFWA using plasma samples from patients in the critical care unit.
Materials and Methods The fibrinolysis times using CFWA were measured in 298 plasma samples. These samples were divided into three groups based on the reference interval (RI) of fibrinolysis time using CFWA: shortened group, less than RI; within group, within RI; prolonged group, more than RI. The coagulation and fibrinolysis markers, including D-dimer, plasmin–α2 plasmin inhibitor complex (PIC), fibrin monomer complex (FMC), plasmin–α2 plasmin inhibitor (α2-PI), plasminogen (Plg), and fibrinogen (Fbg) were analyzed and compared among the three groups.
Results The FMC level decreased in the order of shortened, within, and prolonged groups, and the decrease was statistically significant among all three group pairs. The opposite tendency was observed for Fbg and fibrinolysis-related markers of α2-PI and Plg, and significant differences were recognized in all pair comparisons except for between within and prolonged groups in Plg. The mean values of the fibrinolysis markers D-dimer and PIC in all three groups were higher than the cut-off values, and the PIC value differed significantly between the within and prolonged groups.
Conclusion The fibrinolysis reaction was detected in all three groups, but the status differed. CFWA has the potential to reflect the fibrinolysis status in one global assay.
A Novel Risk Prediction Score for Clinically Significant Bleeding in Patients Anticoagulated for Venous Thromboembolism with Active Cancer
Authors: Cohen Alexander T. , Wallenhorst Christopher , Choudhuri Satarupa , Nassar Ayman , Pollock Kevin G. , Martinez Carlos 
Published: August 2023

Background Cancer-associated venous thromboembolism (Ca-VTE) treatment with anticoagulation is associated with bleeding complications and there are limited data on risk factors. Current models do not provide accurate bleeding risk prediction.
Methods UK Clinical Practice Research Datalink data (2008–2020) were used to generate a cohort of patients with anticoagulant initiation for first Ca-VTE. Patients were observed up to 180 days for significant bleeding including major bleeding and clinically relevant nonmajor bleeding requiring hospitalization (CRNMB-H). A scoring scheme was developed from sub-distribution hazard ratios, and its discrimination (expressed by the C-statistic) estimated from cross-validation.
Results A total of 15,749 patients with Ca-VTE and anticoagulant treatment were included. In total, 537 significant bleeding events, 161 major bleeds, and 376 CRNMB-H were identified after adjudicated review in 4,914 person-years of observation. Incidence rates of 3.3 and 7.7 per 100 person-years were noted for major bleeding and CRNMB-H. Independent predictors of significant bleeding included cancer of the bladder, central nervous system, cervix, kidney, melanoma, prostate and upper gastrointestinal tract, metastases, minor surgery, minor trauma, and history of major bleeding or CRNMB (before or after the Ca-VTE diagnosis). Patients recognized as low, medium, and high risk (30.4, 56.8, and 1.7% of the population, respectively) had a 6-month significant bleeding incidence rate of 5.1, 19.0, and 56.5 per 100 person-years, respectively. Overall C-statistic for significant bleeding was 0.70 (95% confidence interval: 0.65–0.75), and 0.76 (0.68–0.84) and 0.67 (0.61–0.73) for major bleeding and for CRNMB-H, respectively.
Conclusion This risk score may identify patients at risk of significant bleeding, while also helping to determine treatment duration.
Protective Effect and Mechanism of Autophagy in Endothelial Cell Injury Induced by Hyperoxia
Authors: Zhu Xiaodan , He Shasha , Zhang Rong , Kang Lan , Lei Xiaoping , Dong Wenbin 
Published: July 2023

Objective Bronchopulmonary dysplasia is a chronic lung disease in premature infants with alveolar simplification and pulmonary vascular development disorder as the main pathological feature and hyperoxia as the main etiology. Autophagy is a highly conserved cytological behavior of self-degrading cellular components and is accompanied by oxidative stress. Studies have reported that autophagy is regulated by FOXO1 posttranslational modification. However, whether autophagy can be involved in the regulation of endothelial cell injury induced by hyperoxia and its mechanism are still unclear.
Study Design We have activated and inhibited autophagy in human umbilical vein endothelial cells under hyperoxia and verified the role of autophagy in endothelial cell-related functions from both positive and negative aspects.
Results Our research showed that the expression level of autophagy-related proteins decreased, accompanied by decreased cell migration ability and tube formation ability and increased cell reactive oxygen species level and cell permeability under hyperoxia conditions. Using an autophagy agonist alleviated hyperoxia-induced changes and played a protective role. However, inhibition of autophagy aggravated the cell damage induced by hyperoxia. Moreover, the decrease in autophagy proteins was accompanied by the upregulation of FOXO1 phosphorylation and acetylation.
Conclusion We concluded that autophagy was a protective mechanism against endothelial cell injury caused by hyperoxia. Autophagy might participate in this process by coregulating posttranslational modifications of FOXO1.
Key Points
Virtues and shortcomings of guidance and tutoring in higher education: a longitudinal study of the TIMONEL Project
Authors: Pantoja-Vallejo Antonio , Martín-Romera Ana , Pueyo-Villa Silvia , Berrios-Aguayo Beatriz 
Published: July 2023

AbstractThis research is established within the framework of Project TIMONEL, developing in three phases under a concurrent mixed research model. The ultimate goal was to create a Web Recommendation System (RS) to complete the tutorial and guidance work of university professors. Both qualitative and quantitative data are collected from a large sample of students and professors from different European universities on the needs and situation of guidance practice (phase 1). In addition, certain cases are investigated and the reasons, knowledge, feelings and good practices in guidance and tutoring are explored, in order to identify opportunities for improvement and elements that enable the design of the RS (phase 2). The data collected in the first and second phases of project development were used to finally build a SR capable of receiving feedback from user contributions (phase 3). Finally, the SR was evaluated, proving to be a tool of great use for university students and faculty.
Heat capacity changes associated with G-quadruplex unfolding
Authors: Garabet Arees , Liu Lutan , Chalikian Tigran V. 
Published: August 2023

G-quadruplexes are four-stranded DNA structures that have been found in the cell and are thought to act as elements of control in genomic events. The measurements of the thermodynamic stability, ΔG, of G-quadruplexes shed light on the molecular forces involved in the stabilization of these structures. In thermodynamic studies, the differential heat capacity, ΔCP, of the folded and unfolded states of a G-quadruplex is a fundamental property that describes the temperature dependences of the differential enthalpy, ΔH, entropy, ΔS, and free energy, ΔG. Despite its recognized importance, the ΔCP of G-quadruplex unfolding has not been measured directly. Here, we use differential scanning calorimetry to evaluate changes in heat capacity, ΔCP, accompanying the unfolding transitions of G-quadruplexes formed by modified DNA sequences from the promoter regions of the c-MYC, VEGF, and Bcl-2 oncogenes. The average value of ΔCP is 0.49 ± 0.12 kcal mol−1 K−1. Our analysis revealed that disregarding ΔCP leads to significant errors in extrapolated values of the differential enthalpy, ΔH, and entropy, ΔS, of the folded and unfolded DNA conformations. Although the compensation between ΔH and ΔS weakens the effect of ΔCP on the differential free energy, ΔG, neglecting ΔCP may still result in relative errors in ΔG extrapolated to room temperature as great as 140%. We emphasize the importance of proper consideration of the effect of ΔCP in conformational studies of guanine-rich DNA molecules.
Recent advances on low-Co and Co-free high entropy layered oxide cathodes for lithium-ion batteries
Authors: Yu Binkai , Wang Yuqiu , Li Jiaqi , Jin Yuqin , Liang Zixin , Zhou Limin , Chen Mingzhe 
Published: August 2023

Abstract
As the price of the precious metal cobalt continues to rise, there is an urgent need for a cobalt-free or low-cobalt electrode material to reduce the cost of lithium-ion batteries, which are widely used commercially, while maintaining their performance as much as possible. With the introduction of the new concept of high entropy (HE) materials into the battery field, low cobalt and cobalt free HE novel lithium-ion batteries have attracted great attention. It possesses important research value to use HE materials to reduce the use of cobalt metal in electrode materials. In this perspective, the comparison between the new cathode materials of low cobalt and cobalt-free HE lithium-ion battery and traditional cathode materials and the latest progress in maintaining structural stability and conductivity are introduced. It is believed that low cobalt and cobalt-free and HE layered oxides can be used to replace the function of cobalt in the cathode materials of lithium-ion batteries. Finally, the future research directions and the synthesis method of HE cathode materials for lithium-ion batteries are also discussed.
Novel synthetic approach of 2D-metal–organic frameworks (MOF) for wastewater treatment
Authors: Nath Nibedita , Chakroborty Subhendu , Pal Kaushik , Barik Arundhati , Soren Siba 
Published: August 2023

Abstract
In addition to their adjustable functionality, structural tunability, and compositional tunability, metal–organic frameworks (MOFs), often known as MOFs, are a distinct form of crystalline porous material. When reduced to two dimensions, ultrathin layers of MOF retain more of its fantastic external features, which is beneficial for a variety of technological applications. Due to their ultrathin atomic-level thickness, easily modifiable structure, and huge surface area, 2D MOF nanosheets and nanocomposites have been the subject of significant research. MOFs are considered intriguing materials for removing toxic contaminants among the novel technologies taken into account in water remediation processes because they exhibit numerous qualities that make them advantageous in water treatment: large surface area, easily functionalizable cavities, a few stable in water, large-scale synthesis, etc Nowadays, water pollution is a rising environmental concern that must be addressed. Due to their special qualities, which include chemical activities, a variety of functionalities, excellent stability, and the ability to be modified for the detection or adsorption of particular molecules, MOFs are widely used in detecting and removing contaminants from water. This review explores most recent wastewater treatment advancements (WWT) using the 2D MOFs mechanism.
Barometric characterization of a draining container
Authors: Salinas Isabel , Muñoz-Pérez Francisco M , Castro-Palacio Juan C , Velazquez Luisberis , Monsoriu Juan A 
Published: August 2023

Abstract
A characterization of a draining container is performed by measuring the pressure change at its bottom while the container drains through a small orifice. The Physics model is based on the continuity equation and Bernoulli’s principle. The pressure is measured with the barometer of the smartphone which is placed inside a hermetically sealed bag and laid at the bottom of the container. The expected theoretical relationship between the pressure at the bottom of the container and time was observed. The value for the coefficient of discharge is also estimated. The results of a survey applied to students and teachers at secondary school level indicate that the use of the pressure sensor of the smartphones helped the students to understand the basic concepts of hydrostatics and hydrodynamics at the same time their motivation for physics was increased.
A review on transport characteristics and bio-sensing applications of silicene
Authors: Ghosal Supriya , Bandyopadhyay Arka , Chowdhury Suman , Jana Debnarayan 
Published: August 2023

Abstract
Silicene, a silicon counterpart of graphene, has been predicted to possess Dirac fermions. The effective spin–orbit interaction in silicene is quite significant compared to graphene; as a result, buckled silicene exhibits a finite band gap of a few meV at the Dirac point. This band gap can be further tailored by applying in plane strain, an external electric field, chemical functionalization and defects. This special feature allows silicene and its various derivatives as potential candidates for device applications. In this topical review, we would like to explore the transport features of the pristine silicene and its possible nano derivatives. As a part of it, Thermoelectric properties as well as several routes for thermoelectric enhancement in silicene are investigated. Besides, the recent progress in biosensing applications of silicene and its hetero-structures will be highlighted. We hope the results obtained from recent experimental and theoretical studies in silicene will setup a benchmark in diverse applications such as in spintronics, bio-sensing and opto-electronic devices.
Constraining study of circular orbits and accretion disk around nonlinear electrodynamics black hole
Authors: Ditta A. , Mustafa G. , Abbas G. , Atamurotov Farruh , Jusufi Kimet 
Published: August 2023

Abstract
The very latest observation of M87 supermassive black hole (BH) by the Event Horizon Telescope (EHT) provides the accretion onto BHs is an interesting study in the theory of gravity. We study the geodesics structure and accretion near a nonlinear electrodynamics BH in strong and weak field approximations. These approximations provide the disc-like structure under the geodesic motion and accretion around the BH. Near the equatorial plane, we provide some new reasons to make circular orbits and accretion of test particles around the BH. Then we investigate perturbations, the critical speed of the fluid and the mass accretion rate of particles around the central object. The physical validity of this study shows that the parameter β and Q play an important role in the circular orbits and the mass accretion rate in strong and weak field approximations.
JWST MIRI Flight Performance: Detector Effects and Data Reduction Algorithms
Authors: Morrison Jane E. , Dicken Daniel , Argyriou Ioannis , Ressler Michael E. , Gordon Karl D. , Regan Michael W. , Cracraft Misty , Rieke George H. , Engesser Michael , Alberts Stacey , Alvarez-Marquez Javier , Colbert James W. , Fox Ori D. , Gasman Danny , Law David R. , Garcia Marin Macarena , Gáspár András , Guillard Pierre , Kendrew Sarah , Labiano A. , Laine Seppo , Noriega-Crespo A. , Shivaei Irene , Sloan G. C. 
Published: August 2023

Abstract
The detectors in the Mid-Infrared Instrument (MIRI) of the James Webb Space Telescope (JWST) are arsenic-doped silicon impurity band conduction (Si:As IBC) devices and are direct descendants of the Spitzer IRAC long wavelength arrays (channels 3 and 4). With appropriate data processing, they can provide excellent performance. In this paper we discuss the various non-ideal behaviors of these detectors that need to be addressed to realize their potential. We have developed a set of algorithms toward this goal, building on experience with previous similar detector arrays. The MIRI-specific stage 1 pipeline algorithms, of a three stage JWST calibration pipeline, were developed using pre-flight tests on the flight detectors and flight spares and have been refined using flight data. This paper describes these algorithms, which are included in the first stage of the JWST Calibration Pipeline for the MIRI instrument.