bluuebunny/crossref_metadata_2025_split huggingface dataset:
Helicobacter pylori multiplex serology and risk of non-cardia and cardia gastric cancer: a case-cohort study and meta-analysis
Authors: Yao Pang , Kartsonaki Christiana , Butt Julia , Jeske Rima , de Martel Catherine , Plummer Martyn , Guo Yu , Clark Sarah , Walters Robin G , Chen Yiping , Avery Daniel , Lv Jun , Yu Canqing , Wang Hao , Hill Michael , Peto Richard , Li Liming , Waterboer Tim , Chen Zhengming , Millwood Iona Y , Yang Ling 
Published: March 2023

Abstract

Background
Helicobacter pylori infection is a major cause of non-cardia gastric cancer (NCGC), but uncertainty remains about the associations between sero-positivity to different H. pylori antigens and risk of NCGC and cardia gastric cancer (CGC) in different populations.

Methods
A case-cohort study in China included ∼500 each of incident NCGC and CGC cases and ∼2000 subcohort participants. Sero-positivity to 12 H. pylori antigens was measured in baseline plasma samples using a multiplex assay. Hazard ratios (HRs) of NCGC and CGC for each marker were estimated using Cox regression. These were further meta-analysed with studies using same assay.

Results
In the subcohort, sero-positivity for 12 H. pylori antigens varied from 11.4% (HpaA) to 70.8% (CagA). Overall, 10 antigens showed significant associations with risk of NCGC (adjusted HRs: 1.33 to 4.15), and four antigens with CGC (HRs: 1.50 to 2.34). After simultaneous adjustment for other antigens, positive associations remained significant for NCGC (CagA, HP1564, HP0305) and CGC (CagA, HP1564, HyuA). Compared with CagA sero-positive only individuals, those who were positive for all three antigens had an adjusted HR of 5.59 (95% CI 4.68–6.66) for NCGC and 2.17 (95% CI 1.54–3.05) for CGC. In the meta-analysis of NCGC, the pooled relative risk for CagA was 2.96 (95% CI 2.58–3.41) [Europeans: 5.32 (95% CI 4.05–6.99); Asians: 2.41 (95% CI 2.05–2.83); Pheterogeneity&lt;0.0001]. Similar pronounced population differences were also evident for GroEL, HP1564, HcpC and HP0305. In meta-analyses of CGC, two antigens (CagA, HP1564) were significantly associated with a higher risk in Asians but not Europeans.

Conclusions
Sero-positivity to several H. pylori antigens was significantly associated with an increased risk of NCGC and CGC, with varying effects between Asian and European populations.
Extensive Evaluation of a Method for Quantitative Measurement of Aflatoxins B1 and M1 in Animal Urine Using High-Performance Liquid Chromatography with Fluorescence Detection
Authors: Du Xiangwei , Schrunk Dwayne E , Imerman Paula M , Tahara John , Tkachenko Andriy , Guag Jake , Reimschuessel Renate , Rumbeiha Wilson K 
Published: March 2023

Abstract

Background
Aflatoxins (AFs) are common feed contaminants and are one of the common causes of toxin-related pet food poisoning and recalls.

Objective
Currently, there are no validated methods for the detection and quantitation of AFs in biological matrices to diagnose AF exposure in live animals. Following a successful intra-laboratory method development to quantify AFB1 and AFM1 in animal urine by HPLC with fluorescence detection (HPLC–FLD), the present study was conducted to extensively evaluate the method performance in an unbiased manner using blinded samples.

Methods
The evaluation included two stages. First, the performance was verified in the method-originating laboratory in a single-laboratory blinded method test (BMT-S) trial followed by a multi-laboratory blinded method test (BMT-M) trial.

Results
In both trials, accuracy, repeatability, and reproducibility were satisfactory confirming the relatively good ruggedness and robustness of the method and ensuring that it will perform as expected if used by other laboratories in the future.

Conclusions
We extensively evaluated the performance of a quantitative method to detect AFB1 and AFM1 in animal urine by HPLC-FLD by two different laboratories in two separate BMT-S and BMT-M trials. Both BMT results demonstrated the satisfactory accuracy and precision of the method. It is now available to be adopted by other diagnostic laboratories for purposes of diagnosing AF intoxication in animals.

Highlights
A simple urine-based diagnostic test method using HPLC–FLD that originated in a single laboratory now has passed a multi-laboratory evaluation and is now available to be shared with other diagnostic laboratories for purposes of diagnosing AF intoxication in animals so better treatment can be rendered.
Effectiveness of proton beam therapy for liver oligometastatic recurrence in patients with postoperative esophagus cancer
Authors: Yamaguchi Hisashi , Kato Takahiro , Honda Michitaka , Hamada Koichi , Seto Ichiro , Tominaga Takuya , Takagawa Yoshiaki , Takayama Kanako , Suzuki Motohisa , Kikuchi Yasuhiro , Teranishi Yasushi , Murakami Masao 
Published: March 2023

AbstractThere are several reports of hepatic resection for postoperative hepatic metastatic recurrence of esophageal cancer. However, it is unclear whether surgery is the best local treatment for liver metastases. Thus, this study aimed to retrospectively analyze proton beam therapy (PBT) for postoperative liver metastatic recurrence of esophageal cancer without extrahepatic lesions and examine outcomes and adverse events. This single-center historical cohort study selected patients who underwent PBT at our proton therapy center between 2012 and 2018. The patients were selected based on the following criteria: primary esophagus carcinoma was resection and metachronous liver oligometastasis recurrence without extrahepatic tumors and no more than three liver metastases. This study included seven males with a median age of 66 (range, 58–78) years, and 15 lesions were included in the study. The median tumor size was 22.6 (7–55.3) mm. The most frequent dose was 72.6 Gy relative biological effect (RBE)/22 fractions (fr) for four lesions and 64 Gy (RBE)/8 fr for four lesions. The median survival time was 35.5 (13.2–119.4) months. The 1-, 2- and 3-year overall survival (OS) rates were 100%, 57.1% and 42.9%, respectively. The median progression-free survival (PFS) time was 8.7 (1.2–44.1) months. The 1-, 2- and 3-year PFS rates were 28.6%. The 1-, 2- and 3-year local control (LC) rates were 100%. No grade ≥4 radiation-induced adverse events (AEs) were observed. We conclude that PBT can be considered an alternative to hepatic resection for recurrent liver metastases postoperative esophageal cancer.
Odds ratios as a measure of disproportionate treatment: application to jury venires
Authors: Kadane Joseph B 
Published: March 2023

AbstractOdds ratios have several advantages over other methods of measuring the degree of under-representation of cognizable classes of potential jurors. In particular, its advantage over comparative disparity is that it does not measure the extent of under-representation of some groups against an aggregate that includes the very group in question. Odds ratios in jury analysis are directly interpretable as the factor by which one’s probability of being on the jury is advanced or diminished by membership in a specified group.
The B & V light curves for recurrent nova T CrB from 1842–2022, the unique pre- and post-eruption high-states, the complex period changes, and the upcoming eruption in 2025.5 ± 1.3
Authors: Schaefer Bradley E 
Published: March 2023

ABSTRACT
T CrB is one of the most-famous and brightest novae known, and is a recurrent nova with prior eruptions in 1866 and 1946 that peak at V = 2.0. I have constructed light curves spanning 1842–2022 with 213 730 magnitudes, where the B and V magnitudes are fully corrected to the Johnson system. These light curves first reveal a unique complex high-state (with 20× higher accretion rate than the normal low-state) stretching from −10 to +9 yr after eruption, punctuated with a deep pre-eruption dip (apparently from dust formation in a slow mass ejection) and a unique enigmatic secondary eruption (with 10 per cent of the energy of the primary eruption), with the light curves identical for the 1866 and 1946 eruptions. Starting in 2015, T CrB entered the high-state, like in 1936, so a third eruption in upcoming years has been widely anticipated. With the pre-1946 light curve as a template, I predict a date of 2025.5 ± 1.3 for the upcoming eruption, with the primary uncertainty arising from a possible lengthening of the pre-eruption high-state. I use the large-amplitude ellipsoidal modulation to track the orbital phase of the binary from 1867–2022. I measure that the orbital period increased abruptly by +0.185 ± 0.056 d across the 1946 eruption, the 1947–2022 years had a steady period decrease of (−8.9 ± 1.6) × 10−6 d-per-day, and the 1867–1946 years had a steady period change consistent with zero, at (+1.75 ± 4.5) × 10−6 d-per-day. These large period changes cannot be explained by any published mechanism.
Symmetric control of sister chromatid cohesion establishment
Authors: Zhang Jiaxin , Li Lili , Miao Yu , Liu Xiaojing , Sun Haitao , Jiang Meiqian , Li Xiaoli , Li Zhen , Liu Cong , Liu Baohua , Xu Xingzhi , Cao Qinhong , Hou Wenya , Chen Chunlai , Lou Huiqiang 
Published: March 2023

Abstract
Besides entrapping sister chromatids, cohesin drives other high-order chromosomal structural dynamics like looping, compartmentalization and condensation. ESCO2 acetylates a subset of cohesin so that cohesion must be established and only be established between nascent sister chromatids. How this process is precisely achieved remains unknown. Here, we report that GSK3 family kinases provide higher hierarchical control through an ESCO2 regulator, CRL4MMS22L. GSK3s phosphorylate Thr105 in MMS22L, resulting in homo-dimerization of CRL4MMS22L and ESCO2 during S phase as evidenced by single-molecule spectroscopy and several biochemical approaches. A single phospho-mimicking mutation on MMS22L (T105D) is sufficient to mediate their dimerization and rescue the cohesion defects caused by GSK3 or MMS22L depletion, whereas non-phosphorylable T105A exerts dominant-negative effects even in wildtype cells. Through cell fractionation and time-course measurements, we show that GSK3s facilitate the timely chromatin association of MMS22L and ESCO2 and subsequently SMC3 acetylation. The necessity of ESCO2 dimerization implicates symmetric control of cohesion establishment in eukaryotes.
Parliament’s Constitution: Legislative Disruption of Implied Repeal
Authors: Hameed Asif 
Published: March 2023

Abstract
UK constitutional law establishes priority rules governing the relations among legal sources. According to the implied repeal rule, a later statute is preferred to and repeals an earlier statute where the two cannot stand together. There is a vast literature testing the rule’s application in future-facing scenarios: whether Parliament in enacting legislation is capable of legally binding its successors. This article instead adopts a backward-facing perspective, focusing on past enactments. I examine Parliament’s legislative power to disrupt how implied repeal applies to earlier, inconsistent statutes. This sheds light on Parliament’s capacity to shape the constitution’s architecture—here, by rearranging priority relations among existing statutes. I juxtapose the technique against the doctrine of constitutional statutes, and also address the implications for the doctrine of parliamentary sovereignty. Nor is the technique simply of academic interest. A backward-facing reprioritising regime has already been established in the legislation governing UK withdrawal from the EU. Lastly, the argument may be generalised to encompass other legislatures that also enjoy powers to disrupt the implied repeal rule normally operating among past statutes.
Genome-wide profiling of rice Double-stranded RNA-Binding Protein 1–associated RNAs by targeted RNA editing
Authors: Yin Shuai , Chen Yuedan , Chen Yache , Xiong Lizhong , Xie Kabin 
Published: March 2023

Abstract
RNA-binding proteins (RBPs) play essential roles in regulating gene expression. However, the RNA ligands of RBPs are poorly understood in plants, not least due to the lack of efficient tools for genome-wide identification of RBP-bound RNAs. An RBP-fused adenosine deaminase acting on RNA (ADAR) can edit RBP-bound RNAs, which allows efficient identification of RNA ligands of RBPs in vivo. Here, we report the RNA editing activities of the ADAR deaminase domain (ADARdd) in plants. Protoplast experiments indicated that RBP-ADARdd fusions efficiently edited adenosines within 41 nucleotides (nt) of their binding sites. We then engineered ADARdd to profile the RNA ligands of rice (Oryza sativa) Double-stranded RNA-Binding Protein 1 (OsDRB1). Overexpressing the OsDRB1-ADARdd fusion protein in rice introduced thousands of A-to-G and T-to-C RNA‒DNA variants (RDVs). We developed a stringent bioinformatic approach to identify A-to-I RNA edits from RDVs, which removed 99.7% to 100% of background single-nucleotide variants in RNA-seq data. This pipeline identified a total of 1,798 high-confidence RNA editing (HiCE) sites, which marked 799 transcripts as OsDRB1-binding RNAs, from the leaf and root samples of OsDRB1-ADARdd–overexpressing plants. These HiCE sites were predominantly located in repetitive elements, 3′-UTRs, and introns. Small RNA sequencing also identified 191 A-to-I RNA edits in miRNAs and other sRNAs, confirming that OsDRB1 is involved in sRNA biogenesis or function. Our study presents a valuable tool for genome-wide profiling of RNA ligands of RBPs in plants and provides a global view of OsDRB1-binding RNAs.
The Overnight Drift
Authors: Boyarchenko Nina , Larsen Lars C , Whelan Paul 
Published: March 2023

Abstract
This paper documents that U.S. equity returns are large and positive during the opening hours of European markets. These returns are pervasive and highly economically and statistically significant. Consistent with models of inventory risk, we demonstrate a strong relationship with order imbalances at the close of the preceding U.S. trading day. Rationalizing unconditionally positive “overnight drift” returns, we uncover an asymmetric reaction to demand shocks: market sell-offs generate robust positive overnight reversals, while reversals following market rallies are much more modest. We argue that demand shock asymmetry can arise in inventory management models with time-varying market maker risk-bearing capacity.
Authors have furnished an Internet Appendix, which is available on the Oxford University Press Web site next to the link to the final published paper online.
Coenzyme Q10 treatment and diazinon exposure in parental male rats: effects of the exposure on their neonatal brains
Authors: Chali Sima Ebadi Naft , Khanbabaei Ramzan , Juybari Abbas Ali Dehpour , Fatahi Esmail , Kalai Roya Bisheh 
Published: March 2023

Abstract
Prenatal acute and chronic exposure to organophosphorus pesticides may evoke physical and behavioral impairments in offspring development. However, the mechanism of antioxidant consumption repair to cure these impairments remains unclear. This study aimed to investigate the protective effects of COQ10 against DZN toxicity by measuring Malondialdehyde (MDA) level, superoxide dismutase (SOD) activity, the expression of MH2A, DNMT1, H2AZ, and HDAC3, and the histopathology in the brain of neonatal Wistar albino rats whose male parents were exposed to DZN and COQ10. The results showed that COQ10 could significantly decrease MDA level, histopathological alteration, and expression of DNMT1 and HDAC3 in the neonatal brain (P &lt; 0.05). Also, an increase in SOD activity and expression of MH2A and H2AZ were observed in the neonatal brain of this group (P &lt; 0.05). These investigations suggest that COQ10 can reduce the effects of DZN on neuronal oxidative stress and its damage to the neonatal brain.
Is it a good choice for physeal distraction osteogenesis to treat CPT patients with tibial shortening?
Authors: Liu Yaoxi , Tan Qian , Liu Kun , Yang Ge , Zhu Guanghui , Wu Jiangyan , Mei Haibo 
Published: March 2023

Objective
The purpose of this study was to evaluate the healing index and complications of distraction osteogenesis through the physis in children with Congenital pseudarthrosis of the tibia (CPT) using Ilizarov external fixation device.

Methods
Nine children with CPT who underwent distraction osteogenesis through the physis surgery with an Ilizarov external fixation device between June 2018 and August 2020 were included in the study. The average follow-up time was 36.1 months. X-ray examination was performed 1 month after physis lengthening, and the callus quality was evaluated using the Li classification. Any complications and the quality of the callus after tibial lengthening were followed up.

Results
The average age at the time of operation was 9.4 years, and the average follow-up time was 36.1  months. The average lengthening length of children with CPT was 6.6 cm. The incidence of good callus morphology was 100%, and the healing index was 51.1 d/cm. The average fixation time of the external fixation device was 316 days. Needle tract infection occurred in one case, ankle stiffness occurred in one case, ankle plantar flexion 20° deformity occurred in one case, angular deformity of the tibial lengthening segment occurred in one case (7°) and limited movement of knee joint occurred in one case (0–20°–70°).

Conclusion
The osteogenic quality of the patients of distraction osteogenesis through the physis with tibial shortening and small diameter of the proximal tibia is good, which provides a choice of operation for the children with CPT.
Vitreous Cortex Remnants Removal With Beveled Vitrectomy Probe During Vitrectomy For Primary Rhegmatogenous Retinal Detachment
Authors: Hwang Sung Ha , Lee Dae Yeong , Nam Dong Heun 
Published: March 2023

Purpose:
To introduce a new surgical technique with a beveled vitrectomy probe for the removal of peripheral vitreous cortex remnants (VCR) in primary rhegmatogenous retinal detachment (RRD).

Methods:
This study was a retrospective case series. From September 2019 to June 2022, 54 patients with complete or partial posterior vitreous detachment who underwent vitrectomy for primary RRD by a single surgeon were enrolled.

Results:
After staining the vitreous with triamcinolone acetonide, the presence of VCR was assessed in detail. If VCR were present, the macular VCR were removed using surgical forceps, and then, a free flap of peripheral VCR was used as a handle for removing peripheral VCR using the beveled vitrectomy probe. Of the total patients, the presence of VCR was confirmed in 16 patients (29.6%). There were no intraoperative or postoperative complications, except for retinal redetachment caused by proliferative vitreoretinopathy, that occurred in only one eye (1.9%).

Conclusion:
Using a beveled vitrectomy probe was a practical solution for removing VCR during RRD vitrectomy because additional instruments were not needed and risk of iatrogenic retinal damage was low.
PREMATURE EMULSIFICATION OF SILICONE OIL AFTER RETINAL DETACHMENT REPAIR IN THE SETTING OF HIGH-INTENSITY EXERCISE
Authors: Cobbs Lucy V. , Soares Rebecca Russ , Spirn Marc , Mehta Sonia 
Published: March 2023

Purpose:
To describe a rare case of silicone oil emulsification that occurred only three months postoperatively. We discuss the implications for postoperative counseling.

Methods:
Retrospective chart review of a single patient.

Results:
Thirty-nine-year-old woman who presented with a right eye macula-on retinal detachment that was repaired with scleral buckle, vitrectomy, and silicone oil tamponade. Her course was complicated by extensive silicone oil emulsification within 3 months postoperatively, most likely because of shear forces induced by her daily CrossFit exercise regimen.

Conclusion:
Typical postoperative precautions after a retinal detachment repair include no heavy lifting or strenuous activity for one week. These restrictions may need to be more stringent and long-term for patients with silicone oil to prevent early emulsification.
Transient visual disturbances are associated with disability and suicide risk in patients with migraine without aura
Authors: Tsao Yu-Chien , Wang Yen-Feng , Fuh Jong-Ling , Chen Wei-Ta , Lai Kuan-Lin , Liu Hung-Yu , Wang Shuu-Jiun , Chen Shih-Pin 
Published: March 2023

Background:
To investigate the characteristics and clinical correlates of transient visual disturbances (TVDs) in patients with migraine without aura (MO). Patients with MO frequently report TVDs, which differ from typical visual aura, but the clinical significance of these TVDs has not been determined.

Methods:
Patients with MO who attended our headache clinics were enrolled. Structured questionnaires were used to acquire data on participants’ headache profiles, disability, comorbidities, and lifetime suicidal ideation and suicide attempts. A semistructured visual phenomenon questionnaire was used to characterize TVDs. Headache specialists interviewed the participants for diagnosis and the verification of questionnaire responses.

Results:
Patients with MO (n = 7200; female/male ratio = 3.56, mean age 40.1 ± 13.4 years) were divided into two groups based on the presence (n = 2488) or absence (n = 4712) of TVDs. Patients with TVDs had more headache-related disability, psychiatric comorbidities, and photophobia than did those without TVDs. Suicidal ideation and suicide attempts were more common among patients with than among those without TVDs [ideation: odds ratio (OR) = 1.92, 95% confidence interval (CI) 1.71-2.15, p < 0.001; suicide attempt: OR = 2.23, 95% CI 1.80-2.75, p < 0.001].

Conclusion:
The presence of TVDs may imply greater migraine-related disability, photophobia, and suicidal ideation/suicide attempt risk in patients with MO.
The coagulome of oral squamous cell carcinoma: examining the role and regulation of coagulation in oral cancers using a systems approach
Authors: Racine Floriane , Soudet Simon , Sevestre Marie-Antoinette , Galmiche Antoine , Saidak Zuzana 
Published: March 2023

Purpose of review
Solid tumors often establish a locally hypercoagulant state that promotes vascular complications, such as venous thromboembolism (VTE). Oral squamous cell carcinoma (OSCC) is associated with a broad range of hemostatic complications. Although VTE rarely occurs in ambulatory patients with OSCC, the coagulation cascade is typically activated by surgical resection and local hemorrhage. We present the recent progress in the understanding of the role and regulation of coagulation in OSCC.

Recent findings
Application of systems biology, using bulk tumor and single cell genomic analyses, unveiled the landscape of the tumor coagulome. Of all tumor types, OSCC express the highest mRNA levels of F3 and PLAU, the genes that encode the tissue factor (TF) and urokinase-type plasminogen activator (uPA), the key regulators of coagulation and fibrinolysis, respectively. It also brought to light the intimate and reciprocal regulation between coagulation/fibrinolysis and the tumor microenvironment (TME).

Summary
OSCC have a specific coagulome, with consequences that likely extend beyond the vascular risk. We discuss the attractive possibility that biomarkers of the coagulation cascade might reflect some important characteristics of the TME, offering new opportunities to better understand the impact of surgical procedures, better predict their oncological outcome and improve current therapeutic approaches.