bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transfer multiscale adaptive convolutional neural network for few-shot and cross-domain bearing fault diagnosis
Authors: Li Fan , Wang Liping , Wang Decheng , Wu Jun , Zhao Hongjun 
Published: August 2023

Abstract
Bearing intelligent fault diagnosis has been researched comprehensively in recent years. However, the scarcity of labeled training samples and various working conditions seriously hinder the widespread application of deep learning based fault diagnosis methods. To address this problem, we propose a transfer multiscale adaptive convolutional neural network (TMACNN), which significantly enhances the performance of deep learning based methods on few-shot and cross-domain bearing fault diagnosis in terms of network architecture and transfer strategy. On the one hand, we design a novel multiscale adaptive convolutional neural network (MACNN) framework that effectively improves the feature extraction and generalization abilities for bearing fault diagnosis by introducing mega-scale convolutions and continuous stacked multiscale convolutions. On the other hand, we propose an innovative transfer strategy for the MACNN that freezes the six stacked multiscale convolutional feature extraction units and fine-tunes the mega-scale convolution unit and the classifier, which are more suitable for few-shot transfer learning. In experiments on the CWRU dataset and Paderborn dataset, our proposed TMACNN outperforms various advanced baseline models for few-shot and cross-domain bearing fault diagnosis.
Prescriptive maintenance for complex products with digital twin considering production planning and resource constraints
Authors: Mao Haoyang , Liu Zhenyu , Qiu Chan , Huang Yu , Tan Jianrong 
Published: August 2023

Abstract
Maintenance is a critical aspect of complex products through entire life cycle, often requiring coordination of production planning and available resources, while previous studies appear to have rarely addressed. With this in mind, this paper presents a prescriptive maintenance framework based on digital twins (DTs) for reducing operational risk and maintenance costs of complex equipment clusters. Virtual entities are firstly constructed for each single asset in multiple dimensions, which use real-time or historical sensing data collected from the physical entities to predict the corresponding remaining useful life (RUL). Then such RUL information is incorporated into a stochastic programming model with chance constraints to enable dynamic decision making. In particular, a risk-based optimization model is formulated to take full account of the physical distances between facilities and production gaps. Further, a dual-sense pyramidal transformer model is proposed to sense important details of data in both time and space while capturing temporal dependencies at different scales. Compared to existing data-driven approaches, the proposed DT-based alternative achieves dynamic real-time interaction between physical and virtual units driven by both models and data, while virtual verification based on high-fidelity models ensures high reliability of maintenance decisions, which has also been validated in an aero-engine maintenance case study.
A new strategy to prepare high-performance copper azide film for micro-initiator
Authors: Wang Shuang , Yang Li , Ren Xiaoting , Tong Wenchao , Li Wei , Li Haojie , Huo Junda 
Published: August 2023

Abstract
Copper azide (CA) has gradually become the chosen priming agent for microexplosive devices as a lead-free green priming agent. However, charge loading is challenging due to its high electrostatic sensitivity, severely limiting its practical application. In this study, copper hydroxide particles were evenly coated on the surface of carbon fiber using electrospinning and quick hot-pressing, and CA-based composites with uniform load were created using the in situ azide technique while keeping good film characteristics. The produced CA-HP film has an electroostatic sensitivity of 3.8 mJ, which is much higher than the raw material of 0.05 mJ. The flame sensitivity has also been increased from 45 to 51 cm, and the use safety has been considerably enhanced. Furthermore, hot-pressed CA-HP films can improve the film’s qualities, such as easy cutting and processing into the required shape, compatibility with MEMS processes, and the ability to successfully detonate secondary explosives with only 1 mg. This novel coupling technology expands the possibilities for developing high-safety primers for micro-initiator.
Compact and ordered swarms of unmanned aerial vehicles in cluttered environments
Authors: Xiong Hui , Ding Yaozu , Liu Jinzhen 
Published: August 2023

Abstract
The globally coordinated motion produced by the classical swarm model is typically generated by simple local interactions at the individual level. Despite the success of these models in interpretation, they cannot guarantee compact and ordered collective motion when applied to the cooperation of unmanned aerial vehicle (UAV) swarms in cluttered environments. Inspired by the behavioral characteristics of biological swarms, a distributed self-organized Reynolds (SOR) swarm model of UAVs is proposed. In this model, a social term is designed to keep the swarm in a collision-free, compact, and ordered collective motion, an obstacle avoidance term is introduced to make the UAV avoid obstacles with a smooth trajectory, and a migration term is added to make the UAV fly in a desired direction. All the behavioral rules for agent interactions are designed with as simple a potential function as possible. And the genetic algorithm is used to optimize the parameters of the model. To evaluate the collective performance, we introduce different metrics such as (a) order, (b) safety, (c) inter-agent distance error, (d) speed range. Through the comparative simulation with the current advanced bio-inspired compact and Vasarhelyi swarm models, the proposed approach can guide the UAV swarm to pass through the dense obstacle environment in a safe and ordered manner as a compact group, and has adaptability to different obstacle densities.
Assessing decadal variability of subseasonal forecasts of opportunity using explainable AI
Authors: Arcodia Marybeth C , Barnes Elizabeth A , Mayer Kirsten J , Lee Jiwoo , Ordonez Ana , Ahn Min-Seop 
Published: August 2023

Abstract
Identifying predictable states of the climate system allows for enhanced prediction skill on the generally low-skill subseasonal timescale via forecasts with higher confidence and accuracy, known as forecasts of opportunity. This study takes a neural network approach to explore decadal variability of subseasonal predictability, particularly during forecasts of opportunity. Specifically, this work quantifies subseasonal prediction skill provided by the tropics within the Community Earth System Model Version 2 (CESM2) Large Ensemble and assesses how this skill evolves on decadal timescales. Utilizing the networks’ confidence and explainable artificial intelligence, physically meaningful sources of predictability associated with periods of enhanced skill are identified. Using these networks, we find that tropically-driven subseasonal predictability varies on decadal timescales during forecasts of opportunity. Further, we investigate the drivers of the low frequency modulation of the tropical-extratropical teleconnection and discuss the implications. Analysis is extended to ECMWF Reanalysis v5 data, revealing that the relationships learned within the CESM2-Large Ensemble holds in modern reanalysis data. These results indicate that the neural networks are capable of identifying predictable decadal states of the climate system within CESM2 that are useful for making confident, accurate subseasonal precipitation predictions in the real world.
Morphologically hypervariable species hinder our knowledge of biodiversity: Daustinia montana (Convolvulaceae) as a case study
Authors: Alencar Juliana , Rodrigues Maciel Jefferson , Teresa Buril Maria 
Published: August 2023

Abstract
Cryptic species continue to intrigue taxonomists over time and hamper biodiversity knowledge. An example of what would be considered a cryptic species is Daustinia montana (Convolvulaceae). Its wide leaf morphology plasticity has led to multiple interpretations and contrasting classifications: from a monotypic to a six-taxa hypothesis. For this work, we tested six taxonomic hypotheses, including an explicit test of a monotypic approach, under a robust statistical analysis, using univariate and multivariate methods. Besides that, we performed a niche analysis to verify the niche occupation of the populations recognized here as possible species. Forty-eight micro and macromorphological characters (qualitative and quantitative) from individuals of 16 populations of D. montana were evaluated. The taxonomic hypothesis that recognizes eight distinct species has the highest support as they also have non-overlapping niches. We conclude that the number of species in Daustinia may be greater than its current circumscription. We also highlight the importance of an integrative systematic approach in the study of biodiversity. This research represents a first step in the specific delimitations of the genus and can also serve as a model to study taxa with wide morphological variability.
Withdrawal and Re-treatment with Filgotinib in Ulcerative Colitis: Post Hoc Analyses of the Phase 2b/3 SELECTION and SELECTIONLTE Studies
Authors: Vermeire Séverine , Feagan Brian G , Peyrin-Biroulet Laurent , Oortwijn Alessandra , Faes Margaux , de Haas Angela , Rogler Gerhard 
Published: August 2023

Abstract

Background and Aims
Maintenance treatment for ulcerative colitis may be discontinued for multiple reasons. This post hoc analysis assessed the efficacy and safety of re-treatment with filgotinib, an oral, once-daily, Janus kinase 1 preferential inhibitor, in the phase 2b/3 SELECTION trial and its long-term extension [LTE] study in ulcerative colitis.

Methods
Partial Mayo Clinic Score [pMCS] response and remission were evaluated in patients who received induction with filgotinib 200 mg [FIL200] or 100 mg [FIL100], were randomized to treatment withdrawal [placebo] during maintenance, and following disease worsening, were re-treated with open-label FIL200 in the LTE study. Factors were evaluated for association with pMCS remission at LTE week 12, and safety outcomes were reported.

Results
Analyses included 86 patients [FIL200: n = 51; FIL100: n = 35]. Median time to disease worsening following treatment withdrawal was 15.1 weeks (95% confidence interval [CI]: 9.1–18.7) for FIL200-induced patients and 9.6 weeks [95% CI: 6.3–12.0] for FIL100-induced patients. Three-quarters [75%] of patients achieved a pMCS response within 4–5 weeks of re-treatment in both groups. At LTE week 48, pMCS remission was achieved by 45.1% and 51.4% of FIL200- and FIL100-induced patients, respectively. Factors independently associated with restoring efficacy included no concomitant use of corticosteroids at induction baseline, and high albumin levels, pMCS remission, and endoscopic score at maintenance baseline. No new safety signals were reported among re-treated patients.

Conclusions
In induction responders, re-treatment with FIL200 following temporary withdrawal from therapy restores response and/or remission in the majority of patients within 12 weeks. Re-treatment is well-tolerated. ClinicalTrials.gov identifiers: NCT02914522, NCT02914535
Endocrine morbidity in neurofibromatosis 1: a nationwide, register-based cohort study
Authors: Kenborg Line , Ebbehoj Andreas , Ejerskov Cecilie , Handrup Mette Møller , Østergaard John R , Hove Hanne , Doser Karoline , Krøyer Anja , Mulvihill John J , Winther Jeanette F , Stochholm Kirstine 
Published: August 2023

Abstract

Objective
Previous studies have found that neurofibromatosis 1 (NF1) is associated with an increased risk for endocrine disorders, but no comprehensive overview of the risk for specific endocrine disorders has been published. We assessed endocrine morbidity in individuals with NF1 from information on hospital admissions, surgery for endocrine disorders, and relevant medication.

Design
A nationwide population registry-based cohort study.

Methods
We identified 2467 individuals with NF1 diagnosed between 1977 and 2013 from the Danish National Patient Register and the RAREDIS database and 20 132 randomly sampled age- and sex-matched population comparisons. Information on endocrine diseases was identified using registrations of discharge diagnoses, surgery, and medication prescriptions. The rates of endocrine disorders in individuals with NF1 were compared with those in the comparison cohort in Cox proportional hazard models.

Results
Individuals with NF1 had a higher rate than the comparison group of any endocrine discharge diagnosis (hazard ratio [HR] 1.72, 95% confidence interval [CI]: 1.58-1.87), endocrine-related surgery (2.03, 1.39-2.96), and prescribed medications (1.32, 1.23-1.42). Increased HRs were observed for diseases and surgical operations of several glands, including pheochromocytoma, and for osteoporosis, and osteoporotic fractures. Decreased rates were observed with drugs for type 2 diabetes. Women with NF1 had higher HRs for surgery of the ovaries, uterus, and sterilization, but lower rates of surgeries of cervix and prescriptions for birth control pills.

Conclusions
Neurofibromatosis 1 is associated with a variety of endocrine disorders, surgery, and medication related to endocrine disease. Awareness of endocrine morbidity is important in the clinical follow-up of individuals with NF1.
Emergency out-of-hours catheter ablation for ventricular arrhythmia storm: a UK and Australian experience
Authors: Bennett Richard G , Turnbull Samual , Sood Ashish , Aung Myat , Duncan Edward , Barman Palash , Thomas Glyn , Nisbet Ashley M , Kumar Saurabh 
Published: August 2023

Abstract

Aims
There are limited data on emergency catheter ablation (CA) for ventricular arrhythmia (VA) storm. We describe the feasibility and safety of performing emergency CA in an out-of-hours setting for VA storm refractory to medical therapy at 2 tertiary hospitals.

Methods and results
Twenty-five consecutive patients underwent out-of-hours (5pm–8am [weekday] or Friday 5pm–Monday 8am [weekend]) CA for VA storm refractory to anti-arrhythmic drugs and sedation. Baseline and procedural characteristics along with outcomes were compared to 91 consecutive patients undergoing weekday daytime-hours (8am-5pm) CA for VA storm. More patients undergoing out-of-hours CA had a left ventricular ejection fraction ≤35% (68% vs. 42%, P = 0.022), chronic kidney disease (60% vs. 20%, P &lt; 0.001), and presented following a resuscitated out-of-hospital cardiac arrest (56% vs. 5%, P &lt; 0.001), compared to the daytime-hours group. During median follow-up (377 [interquartile range 138-826] days), both groups experienced similar survival free from recurrent VA and VA storm. Survival free from cardiac transplant and/or mortality was lower in the out-of-hours group (44% vs. 81%, P = 0.007), but out-of-hours CA was not independently associated with increased cardiac transplant and/or mortality (hazard ratio 1.34, 95% confidence interval 0.61-2.96, P = 0.47). Of the 11 patients in the out-of-hours group who survived follow-up, VA-free survival was 91% and VA storm-free survival was 100% at 1-year after CA.

Conclusion
Out-of-hours CA may occasionally be required to control VA storm and can be safe and efficacious in this scenario. During follow-up, cardiac transplant and/or mortality is common but undergoing out-of-hours CA was not predictive of this composite endpoint.
The relationship of fatty acids to ischaemic heart disease and lifespan in men and women using Mendelian randomization
Authors: Schooling C Mary , Kwok Man Ki , Zhao Jie V 
Published: August 2023

AbstractBackgroundObservationally, polyunsaturated fatty acids (PUFAs) have health benefits compared with saturated fatty acids (SFAs); randomized controlled trials suggest fewer benefits. We used uni- and multi-variable Mendelian randomization to assess the association of major fatty acids and their sub-species with ischaemic heart disease (IHD) overall and sex-specifically and with lifespan sex-specifically, given differing lifespan by sex.MethodsWe obtained strong (P &lt;5x10-8), independent (r2&lt;0.001) genetic predictors of fatty acids from genome-wide association studies (GWAS) in a random subset of 114 999 UK Biobank participants. We applied these genetic predictors to the Cardiogram IHD GWAS (cases = 60 801, controls = 123 504) and to the Finngen consortium GWAS (cases = 31 640, controls = 187 152) for replication and to the UK Biobank for sex-specific IHD and for lifespan based on parental attained age (fathers = 415 311, mothers = 412 937). We used sensitivity analysis and assessed sex differences where applicable.ResultsPUFAs were associated with IHD [odds ratio 1.23, 95% confidence interval (CI) 1.05 to 1.44] and lifespan in men (-0.76 years, 95% CI -1.34 to -0.17) but not women (0.20, 95% CI -0.32 to 0.70). Findings were similar for omega-6 fatty acids and linoleic acid. Independent associations of SFAs, mono-unsaturated fatty acids or omega-3 fatty acids with IHD overall or lifespan in men and women were limited.ConclusionsPUFAs, via specific subspecies, may contribute to disparities in lifespan by sex. Sex-specific dietary advice might be a start towards personalized public health and addressing inequities.
COVID-19 Vaccination Among Patients Receiving Maintenance Renal Replacement Therapy: Immune Response, Real-World Effectiveness, and Implications for the Future
Authors: Rouphael Nadine , Bausch-Jurken Mary 
Published: August 2023

Abstract
Chronic kidney disease affects more than 800 million people worldwide and often progresses to end-stage renal disease, which requires maintenance dialysis. Patients receiving dialysis are at higher risk for severe respiratory infections, including SARS-CoV-2 (the causative agent of COVID-19). In addition, many patients who receive dialysis also receive immunosuppressive treatments for conditions such as systemic vasculitis, systemic lupus erythematosus, or malignancies. Many studies have shown that while mRNA COVID-19 vaccines induce some level of immune response in patients receiving dialysis, the magnitude of response is often lower than that of healthy individuals, and responses rapidly wane. Importantly, the risk of COVID-19–related hospitalization and mortality for patients receiving dialysis is 4- to 8-fold higher compared with the general population. In this article, we summarize recent immunogenicity and real-world outcomes of COVID-19 mRNA vaccination among patients receiving dialysis, with a focus on the 3-dose extended primary series and additional (fourth) doses.
COVID-19 Vaccination in Patients With Cancer and Patients Receiving HSCT or CAR-T Therapy: Immune Response, Real-World Effectiveness, and Implications for the Future
Authors: Hall Victoria G , Teh Benjamin W 
Published: August 2023

AbstractPatients with cancer demonstrate an increased vulnerability for infection and severe disease by SARS-CoV-2, the causative agent of COVID-19. Risk factors for severe COVID-19 include comorbidities, uncontrolled disease, and current line of treatment. Although COVID-19 vaccines have afforded some level of protection against infection and severe disease among patients with solid tumors and hematologic malignancies, decreased immunogenicity and real-world effectiveness have been observed among this population compared with healthy individuals. Characterizing and understanding the immune response to increasing doses or differing schedules of COVID-19 vaccines among patients with cancer is important to inform clinical and public health practices. In this article, we review SARS-CoV-2 susceptibility and immune responses to COVID-19 vaccination in patients with solid tumors, hematologic malignancies, and those receiving hematopoietic stem cell transplant or chimeric-antigen receptor T-cell therapy.
Acinetobacter oleivorans IRS14 alleviates cold stress in wheat by regulating physiological and biochemical factors
Authors: Ali Ashif , Dindhoria Kiran , Kumar Rakshak 
Published: August 2023

Abstract

Aims
Climate change is responsible for extreme cold winters, causing a significant loss in crop yield and productivity due to chilling stress. This study aims to investigate the potential of psychrotrophic plant growth-promoting rhizobacteria (PGPR) strain to promote wheat growth under cold stress and explore the adaptive responses of wheat.

Methods and results
Wheat seeds and seedlings were inoculated with the psychrotrophic strain IRS14 and the plants were cultivated for five weeks at 6°C ± 2°C. The genetic, biochemical, physiological, and molecular analysis of the bacterium and plant was done to evaluate the effect of the PGPR strain in alleviating chilling stress. IRS14 possesses antioxidant activity and produced multiple phytohormones, which enhanced seed germination (∼50%) and plant growth (∼50%) during chilling stress.

Conclusions
Here, we reported that the application of IRS14 helps to regulate the biochemical and metabolic pathways in wheat plants. It alleviates chilling stress and increases plant growth rate and biomass. Strain IRS14 in wheat effectively increased chlorophyll content, antioxidants, carotenoid, proline, and endogenous phytohormones compared with untreated wheat.
Standardized ileal digestibility of amino acids in extruded full-fat soybean fed to non-gestating, gestating, and lactating sows
Authors: Wang Ya , Wang Ke , Zou Xiangyang , Jiang Xuemei , Zhuo Yong , Che Lianqiang , Wu De 
Published: August 2023

Abstract
This study was conducted to determine and compare the apparent ileal digestibility and standardized ileal digestibility (SID) of crude protein (CP) and amino acids (AA) in extruded full-fat soybean (EFSB) fed to nongestating, midgestating, late-gestating, and lactating sows. Six EFSB samples were collected from different sources. Fourteen nongestating sows (Landrace × Yorkshire; parity 3 to 5) were fitted with a T-cannula at the distal ileum. After recovery, sows were assigned to a replicated 7 × 3 incomplete Latin square design. The diets included a nitrogen-free (NF) diet and six experimental diets (EFSB 1 to 6). Eight midgestating sows (Landrace × Yorkshire; parity 3; day 48 of gestation), eight late-gestating sows (Landrace × Yorkshire; parity 3; day 90 of gestation), and eight lactating sows (Landrace × Yorkshire; parity 3; day 6 of lactation) were all assigned to four dietary treatments in a repeated 4 × 3 incomplete Latin square design. The diets included a NF diet and three experimental diets (EFSB 4 to 6). Results showed that there were significant differences in the AID and SID of CP and other AA in nongestating sows (P &lt; 0.05), the AID and SID values of EFSB 1 to 3 were higher than those of EFSB 4 to 6, and the value of EFSB 5 was the lowest. For midgestating sows, there were differences in the AID of methionine (EFSB 5 had a lower value than EFSB 4 and 6) (P &lt; 0.01). For late-gestating sows, only the AID of methionine (EFSB 5 had a lower value than EFSB 4 and 6), tryptophan (EFSB 5 had a higher value than EFSB 4 and 6), and proline (EFSB 5 had a higher value than EFSB 4) was different (P &lt; 0.05), and the SID of methionine (EFSB 4 had a higher value than EFSB 5) and tryptophan (EFSB 5 had a higher value than EFSB 4 and 6) was different (P &lt; 0.05). The SID of histidine and valine was greater in lactation than in nongestation (P = 0.045 and P = 0.02, respectively). The SID of isoleucine was greater in lactation than in nongestation and gestation (P &lt; 0.01). The SID of methionine in nongestation was lower than in gestation and lactation (P &lt; 0.01). The SID of cysteine was the lowest in midgestation (P = 0.045), and the SID of proline was greater in midgestation than in lactation and nongestation (P &lt; 0.01). In conclusion, the AA ileal digestibility of six EFSB samples from different sources was different, and the ileal digestibility of CP and most AA was not affected by the physiological stage of sows.