bluuebunny/crossref_metadata_2025_split huggingface dataset:
Frequency of Cardiac Arrhythmias in Hypertensive Patients
Authors: Tariq Muhammad Naeem , Samore Naseer Ahmed , Rashid Muhammad Humayoun , Aziz Sohail , Chaudhery Ghoza , Ali Jahanzab , Azad Naseem , Noeman Ahmad , Yamin Bukhari Syeda Neelam , Chaudhry Azhar Ali 
Published: December 2022

Objective: To determine the frequency of cardiac arrhythmias in hypertensive patients.
Study Design: Analytical Cross -sectional study.
Place & Duration of Study: Tertiary Cardiac Center, Lahore Pakistan from Jan 2021 to Dec2021.
Methodology: Two hundred patients (males and females), age between 20-80 years, suffering from hypertensive disease (Blood Pressure ≥ 140/90mmHg), one year before were assessed in the study. After that ECG was done according to International standards. Then patients undergone 24 hour Holter monitoring test. Presence of cardiac arrhythmia was confirmed by the interpretation of 12 lead ECG and 24 hour Holter report. All the data was noted. Patients with cardiac arrhythmias were treated in consultation from the Electrophysiology (EP) department of the hospital. By using the SPSS version 26, the statistical data was tabulated, analyzed and interpreted.
Results: The mean age was calculated to be 58.64±7.74 years. In this study the males were 148(74%) while 52(26%) were females. The mean duration of hypertension was found to be 5.09±1.56 years. Cardiac arrhythmias were noted in 22(11%) cases. Out of 22 cases of cardiac arrhythmias, 02(1%) patients had premature atrial contractions, 02(1%) had atrial flutter, 04(2%) had premature ventricular contractions and 14(7%) had atrial fibrillation. Cardiac arrhythmias were significantly higher in patients above 40 years of age (p<0.05). There was no difference in both genders as well as duration of hypertension has unremarkable effect on cardiac arrhythmias (p>0.05).
Conclusion: The research study concluded that in hypertensive patients, the cardiac arrhythmias frequency is low but its value is not unremarkable.
Frequency of In-Stent Restenosis among Different 2nd/3rd Drug Eluting Stents in Patients Presenting with ACS/Angina at Trtiary Cradiac Care Centre
Authors: Ghaffar Shakir , Rehman Waheed-Ur- , Khan Alam , Abbasi Muhammad Amad , Ali Sajjad , Tariq Muhammad Naeem , Arif Zeeshan , Shahzad Syed Khurram , Kamran Javeria 
Published: December 2022

Objective: Primary objective was to determine the frequency of in-stent restenosis (ISR) among second/third generation drug eluting stents (DES), diagnosed angiographically in cardiac catheterization laboratory either in emergency settings or elective stage procedure and to determine the risk factors precipitating ISR.
Study Design: Analytical Cross-sectional study.
Place and Duration of the study: Tertiary Cardiac Care Center of Rawalpindi Pakistan, from Nov 2021 to Apr 2022.
Methodology: After hospital ethical committee approval, medical data of consecutive patients were analyzed. Clinical and bio data were obtained followed by admission. Risk factors for atherosclerosis obtained along with baseline investigations and echocardiogram obtained to calculate ejection fraction. Classified interventional cardiologists analyzed angiographic images and confirmed the presence of ISR. Details of previous angioplasty and type of stent were documented.
Results: Out of total 137 patients, 98(72%) were males and 39(28%) females. 94(68%) patients were diabetic, 102(72%) were hypertensive, 72(52%) had dyslipidemia, 56(40%) were smokers, and 32(23.35%) strong family history of CHD. After coronary angiography we found that frequency of ISR was 32(23%) in patients who had Xlimus sirolimus stent, 34(24.8%) patients had Xience (everolimus eluting stent), 33(24%) had Ultimaster (sirolimus eluting stent), 38(27%) had Biomatrix stent with p-value=0.25.
Conclusion: The clinical presentation of ISR is usually with angina in all new generation DES. There was no statistically significant difference in terms of ISR among second/3rd generation DES. DES ISR not only depends upon the type of DES used but also depends upon multiple patient ...
Effect of Post Dilatation on TIMI Flow in Patients Undergoing Primary Percutaneous Coronary Intervention
Authors: Abbasi Muhammad Amad , Samore Naseer Ahmad , Ali Khurshid , Rehman Waheed-Ur- , Shafique Hafiz Muhammad , Jokhio Abdul Rehman , Tariq Muhammad Naeem , Sana Ayesha , Kamran Javeria , Qureshi Sanam 
Published: December 2022

Objective: To evaluate the impact of post dilatation performed with Non- Compliant Balloon on Angiographical outcome (that is TIMI flow grade) in patients who underwent the primary percutaneous coronary intervention.
Study Design: Retrospective cross-sectional study.
Place and Duration of Study: At Tertiary Cardiac Care Center, Rawalpindi Pakistan from Nov 2020 to Apr 2021.
Methodology: The retrospective data of the all the patients with STEMI was assessed via non-probability consecutive sampling technique and analyzed statistically. The study participants were classified into two categories based on whether they underwent post-dilatation or not, i.e., Category-I: patients who underwent post-dilatation with NC balloon and Category-II: patients who did not undergo post-dilatation. The primary study end-point was post-dilatation TIMI flow grade. Continuous study variables were expressed as Mean±S.D and categorical variables as frequencies and percentages. Chi square test was applied to find the association between study variables by keeping 95% CI and 5 % margin of error. p-value <0.05 was considered statistically significant.
Results: The study included (n=410) eligible patients in total. Majority were males (n=303; 73.9%), 217 (52.9 %) patients underwent PD procedure. TIMI flow grade did not differ significantly between the two study categories (p-value > 0.05). Postprocedural success rate was 81.3% for patients with PD.
Conclusion: The current study illustrates that PD does not adversely affect the final angiographic outcomes when performed after primary angioplasty.
Comparison of Amiodarone with Combined Doses of Magnesium Sulphate and Lidocaine for Prevention of Ventricular Fibrillation Following Coronary Clamp Release During Coronary Artery Bypass Graft Surgery
Authors: Akram Muhammad Adnan , Naseer Mehwish , Fayaz Fakher-e- , Khurshid Hana , Ali Nasir , Chaudhry Imtiaz Ahmed 
Published: December 2022

Objective: To compare the effects of amiodarone with effects of combined doses of magnesium sulphate and lidocaine for prevention of ventricular fibrillation following coronary clamp release during (coronary artery bypass grafting) CABG.
Study Design: Comparative cross sectional study.
Place and Duration of Study: Army Cardiac Centre, Lahore Pakistan, from Jun 2021 to Dec 2021.
Methodology: One hundred patients who reported at Army Cardiac Centre Lahore, Pakistan for coronary artery bypass grafting surgery, were involved in comparative study. Patients satisfying the inclusion criteria were allocated into the LM(Lidocaine Magnesium) and A (Amiodarone) groups. Following aortic cross clamp release, the incidence of ventricular fibrillation (VF) and other arrhythmias was calculated in first 30 minutes and up to 24 hours later. The ionotropic agent used was epinephrine at a rate of 0.05 to 0.1 micrograms/kg/minute. Within 15 minutes of anesthetic induction and 15 minutes after the CPB pump was removed, hemodynamic parameters were assessed and recorded.
Results: Arrhythmias within 30 minutes and up to 24 hours after aortic cross clamp ACC release in A and LM group were compared. The difference between two groups, having arrhythmias and no arrhythmias was statistically insignificant (p≥0.050) except VF up to 24 hours after ACC release. The highest voltage for defibrillation was used in Group-A n=20 (40.0%) and n=27 (54.0%) in L.M group, (p=0.004). The average electrical defibrillations in group-A was less than that of group L.M,(p=0.000). While, the use of ionotropic agent was almost equal in both the groups, (p=0.975).
Conclusion: Overall, the amiodarone group had a decreased incidence of VF when the ACC was released, while the difference was not statistically significant.
Adjunctive use of Ketorolac for Postoperative Pain Management in Elective Cardiac Surgery Patients: A Randomized Control Trial
Authors: Muzaffar Maaida , Khuwaja Amin M. , Ahmed Aftab , Iqtdar Rabia , Chohan Haris Tariq , Siddiqi Rashad 
Published: December 2022

Objective: To compare between the efficacy of Ketorolac and Paracetamol in the management of post-operative pain following elective cardiac surgery.
Study Design: Randomized (single-blind) Control Trial (RCT NCT05361824.)
Place and Duration of Study: This study was conducted in the Surgical Intensive Care Unit (SICU) at the National Institute of Cardiovascular Diseases Hospital, Karachi Pakistan, From 1st Jan to 30th Jun 2021.
Methodology: Randomization of 60 patients undergoing elective cardiac surgery into either Paracetamol (30 control patients) or Ketorolac (30 treatment patients) was done.In addition, to a low dose, short duration background infusion of Nalbuphine, the control group was administered. Injection Paracetamol 1gm every six-hours. Whereas the treatment group was administered injection Ketorolac 30mg every eight-hours. Assessment of pain was done at 6, 12, 18 and 24 hours post-extubation, using a Visual analog scale (VAS). For the purpose of this study, a score of 4 or less was taken as a cut-off for adequate pain control.
Results: VAS score was significantly lower in Ketorolac group as compared to the Paracetamol group at all four-time points with an average rating of 3.2±1.9 vs. 5.3±1.7; p<0.001, 3.5±1.5 vs. 5±1.7; p<0.001, 3.3±1 vs. 5.0±1.4; p<0.001, and 3.0±1.4 vs. 4.3±1.6; p<0.001 at 6, 12, 18, and 24 hours respectively. The total dose of Nalbuphine administered (infusion + bolus doses) over 48 hours post-operatively was 15.3±5.2 vs 25.7±6.8 ml; p<0.001 in the Ketorolac and Paracetamol groups, respectively.
Conclusion: The use of Ketorolac in conjunction with Nalbuphine gives better control over post-operative pain in elective cardiac surgeries than Paracetamol and Nalbuphine.
Incidence and Predictors of Postoperative Atrial Fibrillation after Coronary Artery Bypass Grafting Surgery
Authors: Siddiqeh Musfireh , Khan Imran , Fayaz Fakhar-e- , Hasan Kirmani Syed Muzaffar , Hamshary Mustafa El , . Wahidullah , Khan Zahid M , Javaid Rehana 
Published: December 2022

Objective: To study the incidence of postoperative atrial fibrillation (POAF) and its predictors after coronary artery bypass grafting (CABG) in an Asian cohort.
Study Design: Cross sectional study.
Place and Duration of Study: The study was conducted at the department of Cardiothoracic Surgery, Almana Hospital, Al Khobar, Saudi Arabia, which is a tertiary care hospital. The study duration was form Oct 2019 to Dec 2021.
Methodology: All the male and female consecutive patients with coronary artery disease undergoing coronary artery bypass grafting (CABG) were included in the study. All the surgeries were performed through median sternotomy using cardiopulmonary bypass. Patients with emergency CABG, off pump CABG and those undergoing multiple procedures were excluded from the study. A total of 220 consecutive patients were included in the study. Patients were followed in the perioperative period. Various variables were recorded on a preformed proforma. Patients were divided into two groups, those who had atrial fibrillation (AF) and those who did not have AF. Data was analyzed using SPPS version 23 (SPSS, Inc., Chicago,IL).
Results: The mean age of the patients was 51.50±11 years in the AF group and 49.38±9 years in the no AF group. The incidence of atrial fibrillation postoperatively in our cohort was (n=52, 25%). There was no statistically significant difference between the groups with respect to hypertension and diabetes (p=0.408 and p=0.054) respectively).
Conclusion: In spite of a younger population, the incidence of AF in our cohort undergoing CABG is comparable to the international literature. Lack of preoperative β-blockers, statins and low ejection fraction are predictors of new onset POAF.
Spectrum of Grown up Congenital Heart (GUCH) at Armed Forces Institute of Cardiology/ National Institute of Heart Diease: 10 years Experience
Authors: Akbar Hajira , Nawaid Mohammad Amir , Muzaffar Tabassum , Imtiaz Sana , Ansari Asma 
Published: December 2022

Objective: To determine the spectrum of Grown up Congenital Heart (GUCH) at Armed Forces Institute of Cardiology/National Institute of Heart Dieases.
Study Design: Descriptive cross sectional study.
Place and Duration of Study: Paediatric Cardiac Surgery and Obstetric department of Armed Force Institute of Cardiology/National Institute of Heart Diease, Rawalpindi Pakistan, from 2011 to 2021.
Methodology: It was a descriptive cross sectional study conducted at Paediatric Cardiology, Paediatric Cardiac Surgery and Obstetric department of AFIC/NIHD. After taking informed consent, a total of 1344 patients fulfilling inclusion and exclusion criteria with non probability consecutive sampling were enrolled in study from 2011 to 2021. Diagnosis, transthoracic echocardiography findings, procedural details (cardiac catheterization/cardiac surgery/obstetrical intervention) and outcome of all patients were noted.
Results: Out of 1344 patients, 700 patients had cardiac catheterization. Among patients who underwent cardiac cath, 304(43%)were males and 396(56.6%) were females. 279(39%) diagnostic and 421(61%) cardiac interventional procedures were done.Most common procedure done was ASD device closure in 227(32%) patients. Complications were seen in 29(4%) patients and mortality in 3(0.4%) patients. There were a total of 188 patients who underwent congenital cardiac surgery. Out of patients who underwent congenital cardiac surgery procedures, 96(51%) were male and 92(49%) were female patients. Major complications were observed in 51(25%) patients and the mortality was 11(5%).There were total of 456 patients in obstetrics department. Out of 456 patients, 54(11%) were with congenital cardiac lesions .The most common defect was VSD 27(6%)patients and dilated cardiomyopathy (DCM) 27(6%) patients followed by ASD and TOF. The maternal and fetal mortality was12(2.7%) and 22(5.5%) respectively.
Conclusion:With immense advancement in diagnosis and management of congenital cardiac diseases, a significant number of patients remain undiagnosed and untreated till the time they present as GUCH. Most common presentation is ASD which is mostly manageable by transcatheter intervention, however late presentation carries a risk of complications like pulmonary hypertension.
A Caminho de Yauyos, uma campanha eleitoral em segundo plano
Authors: Radomsky Guilherme F. W. 
Published: December 2022

Quem sai de Lima, Peru, pela estrada Panamericana sentido sul, vislumbra uma paisagem que margeia o frio oceano Pacífico de um lado, enquanto se avolumam os pálidos morros esbranquiçados de outro. Não raro se aparecem favelas e moradias populares à vista, subindo as íngremes encostas peladas e num relance de pensamento não sabemos como as casas permanecem em pé na areia em declive. A paisagem se torna dramática também porque as casinhas são vistas contrapostas às praias de veraneio dos limeños de classe média alta com suas chamativas mansões de temporada.Ao se chegar em San Vicente de Cañete para subir a serra próxima da capital peruana, o verde dos vales começa a se pronunciar e os rios que correm para o mar são ladeados por colinas. Neste ponto do trajeto que um estranho plano de fundo prendeu minha atenção e originou a narrativa aqui exposta.Parte desse recorrido no fim de dezembro de 2010 era guiado por imagens recorrentes: passando por cidades e vilas chegando até o espaço rural, que nos dá impressão de remoto, a campanha visual de Keiko Fujimori (filha do ex-mandatário do país vizinho) para presidência do Peru em 2011 quase não dá trégua.Durante o trajeto, nas situações menos esperadas, “Fuerza Keiko” estava lá, sempre em segundo plano. Asia, Lunahuana, Zuñiga, Catahuasi, Capillucas e outras pequenas localidades no caminho de Yauyos, nosso destino. Eventualmente só “K” nos relembra da política partidária nos lugares recônditos. Procissão, festa, desfile, trabalho de pastoreio, uma efervescência de acontecimentos, e a campanha eleitoral do partido de direita Força Popular acompanhava o percurso. Curiosamente, num golpe de captura Che Guevara se intromete, mostrando que as forças políticas se chocam até nos detalhes. Foi nesse “acidente”, um olhar que escaneia lentamente as imagens feita no passado, que me deparei mais propriamente com o que Benjamin (1985) denominou de inconsciente óptico, especialmente considerando o tempo que se interpõe neste caso entre o registro das fotografias em campo e a reflexão (Leal, 2013).Na época que as fotografias foram realizadas, havia a sensação de que tudo era movente e transitório, menos as pinturas de Keiko no fundo. No aparelho de captura técnica acionado aqui e ali (Flusser, 2011), o que esvanece e permanece (Soulages, 2010) parecem entrar em conflito nas imagens. Mas as próprias imagens já indicavam uma possível novidade que se tornaria velha logo. Nem Keiko venceu esse pleito, altamente conflitivo e litigioso no Peru como tem sido nas últimas décadas, nem desistiu da candidatura nas eleições seguintes, ficando estas pinturas logo apagadas, talvez substituídas por outras, e pouco propensas a chamar a atenção dos que vivem nessas terras, nem a despertar qualquer sentimento de mudança social por meio da política. A vida seguiu com festas, procissões, desfiles, pastoreios.
Polymorphism of prolactin (PRL) gene exon 5 and its association with egg production in IPB-D1 chickens
Authors: Rohmah Lailatul , Darwati Sri , Ulupi Niken , Khaerunnisa Isyana , Sumantri Cece 
Published: December 2022

Abstract. The prolactin (PRL) gene regulates the egg production and incubation in laying chickens. Local chickens' reproductive systems will disrupt as a result of the incubation period activity, and they will lay fewer eggs. This study aimed to determine the prolactin gene polymorphism in IPB-D1 hens and its relationship to egg production. The polymorphism of the exon 5 prolactin gene was examined on 112 samples of the IPB-D1 chicken DNA collection from the Division of Animal Genetics and Breeding, Faculty of Animal Sciences, IPB University. By performing the phenol–chloroform method, the genomic DNA was obtained. A polymerase chain reaction (PCR) product with a size of 557 bp was produced as a result of the DNA amplification. Three single-nucleotide sequences were discovered. Three single-nucleotide polymorphisms (SNPs), g.7835A > G, g.7886A > T, and g.8052T > C, were found in exon 5 of the PRL gene. Each mutation was polymorphic and in Hardy–Weinberg equilibrium. The point mutation g.8052T > C significantly impacted the egg production of IPB-D1 chickens, according to the SNP association analysis on egg production, and may serve as a marker to enhance the selection for the features of egg production in IPB-D1 chickens.
Nitrogen isotopes reveal a particulate-matter-driven biogeochemical reactor in a temperate estuary
Authors: Dähnke Kirstin , Sanders Tina , Voynova Yoana , Wankel Scott D. 
Published: December 2022

Abstract. Estuaries and rivers are important biogeochemical
reactors that act to modify the loads and composition of nutrients in the
coastal zone. In a case study during July 2013, we sampled an 80 km transect
along the Elbe Estuary under low-oxygen conditions. To better elucidate
specific mechanisms of estuarine nitrogen processing, we tracked the
evolution of the stable isotopic composition of nitrate, nitrite,
particulate matter, and ammonium through the water column. This approach
allowed assessment of the in situ isotope effects of ammonium and nitrite
oxidation and of remineralization at the reach scale. The isotope effects of
nitrite oxidation and ammonium oxidation were consistent with pure-culture
assessments. We found that the nitrogen budget of the Elbe Estuary is
governed by settling, resuspension, and remineralization of particulate
matter, and we further used our stable isotope data to evaluate sources and
sinks of nitrogen in the Elbe Estuary via an isotope mass-balance
approach. We find that the reactivity of particulate matter, through its
remineralization in the estuary, is the main control on the isotope dynamics of
inorganic nitrogen species. Moreover, while underscoring this role of
particulate matter delivery and reactivity, the isotope mass balance also
indicated additional sinks of reactive nitrogen, such as possible
denitrification of water column nitrate in the intensively dredged and deep
Hamburg Harbor region.
Upwelled plankton community modulates surface bloom succession and nutrient availability in a natural plankton assemblage
Authors: Paul Allanah Joy , Bach Lennart Thomas , Arístegui Javier , von der Esch Elisabeth , Hernández-Hernández Nauzet , Piiparinen Jonna , Ramajo Laura , Spilling Kristian , Riebesell Ulf 
Published: December 2022

Abstract. Upwelling of nutrient-rich waters into the sunlit surface
layer of the ocean supports high primary productivity in eastern boundary
upwelling systems (EBUSs). However, subsurface waters contain not only
macronutrients (N, P, Si) but also micronutrients, organic matter and seed
microbial communities that may modify the response to macronutrient inputs
via upwelling. These additional factors are often neglected when
investigating upwelling impacts on surface ocean productivity. Here, we
investigated how different components of upwelled water (macronutrients,
organic nutrients and seed communities) drive the response of surface plankton
communities to upwelling in the Peruvian coastal zone. Results from our
short-term (10 d) study show that the most influential drivers in
upwelled deep water are (1) the ratio of inorganic nutrients
(NOx : PO43-) and (2) the microbial community present that can
seed heterogeneity in phytoplankton succession and modify the stoichiometry of
residual inorganic nutrients after phytoplankton blooms. Hence, this study
suggests that phytoplankton succession after upwelling is modified by
factors other than the physical supply of inorganic nutrients. This would
likely affect trophic transfer and overall productivity in these highly
fertile marine ecosystems.
A global dataset of daily maximum and minimum near-surface air temperature at 1 km resolution over land (2003–2020)
Authors: Zhang Tao , Zhou Yuyu , Zhao Kaiguang , Zhu Zhengyuan , Chen Gang , Hu Jia , Wang Li 
Published: December 2022

Abstract. Near-surface air temperature (Ta) is a key variable in global climate
studies. A global gridded dataset of daily maximum and minimum Ta (Tmax⁡ and Tmin⁡) is particularly valuable and critically needed in
the scientific and policy communities but is still not available. In this paper, we developed a global dataset of daily Tmax⁡ and Tmin⁡
at 1 km resolution over land across 50∘ S–79∘ N from 2003 to 2020 through the combined use of ground-station-based
Ta measurements and satellite observations (i.e., digital elevation model and land surface temperature) via a state-of-the-art
statistical method named Spatially Varying Coefficient Models with Sign Preservation (SVCM-SP). The root mean square errors in our estimates ranged
from 1.20 to 2.44 ∘C for Tmax⁡ and 1.69 to 2.39 ∘C for Tmin⁡. We found that the accuracies were affected
primarily by land cover types, elevation ranges, and climate backgrounds. Our dataset correctly represents a negative relationship between
Ta and elevation and a positive relationship between Ta and land surface temperature; it captured spatial and temporal
patterns of Ta realistically. This global 1 km gridded daily Tmax⁡ and Tmin⁡ dataset is the first of its kind, and we
expect it to be of great value to global studies such as the urban heat island phenomenon, hydrological modeling, and epidemic forecasting. The data have
been published by Iowa State University at https://doi.org/10.25380/iastate.c.6005185 (Zhang and Zhou, 2022).