bluuebunny/crossref_metadata_2025_split huggingface dataset:
Systemic lupus erythematosus flare during SARS‐CoV‐2 infection: Report of 3 cases presented during the fourth wave of the pandemic in Colombia
Authors: Naranjo‐Millán Julián Alberto , Bedoya‐Joaqui Vanessa , Cañas Carlos A. 
Published: March 2023

AbstractBackgroundThe severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) virus has become a worldwide pandemic since first discovered in 2019. Systemic lupus erythematosus (SLE) flare has been reported in the post‐infectious period. In Colombia, the fourth pandemic wave started at the beginning of 2022 when we observed flare of 3 SLE patients during active infection.Case presentationWe describe 3 patients with inactive SLE, who presented coronavirus disease 2019 and severe flare in early 2022, 2 patients with nephritis and 1 with severe thrombocytopenia. All patients had increase of antinuclear and anti‐DNA antibody titers and complement consumption.ConclusionsThree cases with SLE flare concomitant with active SARS‐CoV‐2 infection were different from others reported earlier in the pandemic with post‐infectious flare.
What type of rainforest burnt in the South East Queensland's 2019/20 bushfires and how might this impact biodiversity
Authors: Thorley James , Srivastava Sanjeev Kumar , Shapcott Alison 
Published: March 2023

AbstractBushfires burnt over 18 million hectares across Australia's east coast, including rainforests, over the spring and summer 2019/2020 period. Rainforest harbours a large percentage of Australia's biodiversity and does not usually burn and therefore understanding the extent and biodiversity implications was a priority. The National Indicative Aggregated Fire Extent Dataset (NIAFED) combined with detailed regional ecosystem (RE) mapping was used to estimate the perimeter and area of each of the burnt rainforest types within South East Queensland (SEQ). Previous biodiversity estimates for each rainforest regional ecosystem type combined with remnant ecosystem mapping data then enabled an assessment of the potential biodiversity impacts of the fires for SEQ rainforest. We found that 12% of the rainforest estate in SEQ was within the burn footprint (29 031 ha) including parts of the UNESCO World Heritage Gondwana Rainforests of Australia. Fifty per cent of the total remnant area of the Endangered rainforest type, semi‐evergreen vine thicket on Mesozoic to Proterozoic igneous rocks (RE: 12.12.17) was potentially burnt. This rainforest type has high diversity. Burn severity analysis found that the rainforest primarily burnt with low severity, however, there were patches of high severity. Accuracy assessment of severity mapping resulted in a weak correlation (0.57) due to the underestimation of ground fires in rainforest. As expected, we found rainforest‐suppressed fires. However, in contrast to expectations, we found the wettest rainforest types and putative past refugia burnt more than other rainforest types. These results suggest that given drought conditions any rainforest could burn, and we can expect that the area of rainforest will contract if both incidences of drought and wildfires increase due to climate change.
Unmet mental health need and subsequent substance use in individuals with a history of depression: Are there differences between metro and nonmetro areas?
Authors: Danek Robin , Blackburn Justin , Greene Marion , Mazurenko Olena , Menachemi Nir 
Published: March 2023

AbstractBackground and ObjectivesMore than nine million U.S. adults have a co‐occurring mental health and substance use disorder. The self‐medication hypothesis suggests that individuals with unmet need may alleviate the symptoms of their mental illness by using alcohol or drugs. We examine the relationship between unmet mental health need and subsequent substance use among individuals with a history of depression as well as differences in metro and nonmetro areas.MethodsWe used repeated cross‐sectional data from the National Survey on Drug Use and Health (NSDUH), 2015–2018 after identifying individuals with depression in the past year (n = 12,211). We used logistic regressions with interaction terms to examine the association between unmet need for mental health care and substance use by geographic location.ResultsUnmet mental health need was associated with increased use of marijuana (odds ratio [OR] = 1.32, 95% confidence interval [CI]: 1.08–1.64), illicit drugs (OR = 1.75, 95% CI: 1.19–2.58), and prescription drugs (OR = 1.89, 95% CI: 1.19–3.00) among individuals with depression, which did not vary by geographic location. Unmet need was not associated with increased heavy alcohol drinking (OR = 0.87, 95% CI: 0.60–1.26).Discussion and ConclusionsNo differences in substance usage between metro and nonmetro populations were observed for those with an unmet need for mental health care. We found support for the self‐medication hypothesis among individuals with depression with respect to alcohol.Scientific SignificanceWe examine whether individuals with depression and unmet care needs are more likely to self‐medicate with substances including prescription drugs. Due to higher unmeet needs in nonmetro areas, we examine whether the likelihood of self‐medication differs in metro and nonmetro areas.
Occupancy and abundance of a West African mangabey species (Cercocebus atysAudebert, 1797) in forest patch habitat
Authors: Laity Kellie , Conway April , Hernandez Sonia M. , Carroll John P. , Ejigu Dessalegn 
Published: March 2023

AbstractSooty mangabeys are Old World primates from the Upper Guinea Rainforests of West Africa. They suffer from habitat degradation due to deforestation and hunting for the bush‐meat trade. Tiwai Island and adjacent small islands are a small protected area surrounded by the Moa River that is known for its high diversity of primate species. We evaluated the occupancy and abundance of sooty mangabeys on Tiwai Island and the surrounding islands using camera traps during 2008–2011. Over two seasons, we obtained a naïve occupancy rate of 0.77 for Tiwai Island but only 0.19 for surrounding smaller islands. We used Abundance‐Induced Heterogeneity Model and Royle Repeated Count Model to estimate the abundance of 326 ± 92 (SE) and 530 ± 102 (SE) individuals of sooty mangabeys respectively. Based on these occurrences, sooty mangabeys usually appeared in riparian, mature and young secondary forests. Activity patterns of sooty mangabeys based on circadian patterns of detections confirmed that they were diurnal with several activity peaks during the daylight hours. The results of this study suggest that a viable population of sooty mangabeys still inhabits Tiwai Island and its vicinity, but that their core population is primarily limited to the Tiwai Island reserve. Thus, there is a need to protect the island and its adjacent habitats to ensure the conservation of sooty mangabeys in particular and other primate species in general.
Cardiac output and regional‐cerebral‐oxygen‐saturation in preterm neonates during immediate postnatal transition: An observational study
Authors: Pfurtscheller Daniel , Wolfsberger Christina H. , Höller Nina , Schwaberger Bernhard , Mileder Lukas P. , Baik‐Schneditz Nariae , Urlesberger Berndt , Schmölzer Georg M. , Pichler Gerhard 
Published: March 2023

AbstractAimTo examine potential correlations between cardiac output (CO) with cerebral‐regional‐oxygen‐saturation (crSO2) and cerebral‐fractional‐tissue‐oxygen‐extraction (cFTOE) during immediate foetal‐to‐neonatal transition in term and preterm neonates with and without respiratory support.MethodsPost hoc analyses of secondary outcome parameters of prospective observational studies were performed. We included neonates with cerebral near‐infrared‐spectroscopy (NIRS) monitoring and an oscillometric blood pressure measurement at minute 15 after birth. Heart rate (HR) and arterial oxygen saturation (SpO2) were monitored. CO was calculated with Liljestrand and Zander formula and correlated with crSO2 and cFTOE.ResultsSeventy‐nine preterm neonates and 207 term neonates with NIRS measurements and calculated CO were included. In 59 preterm neonates (mean gestational age (GA): 29.4 ± 3.7 weeks) with respiratory support, CO correlated significantly positively with crSO2 and significantly negatively with cFTOE. In 20 preterm neonates (GA 34.9 ± 1.3 weeks) without respiratory support and in 207 term neonates with and without respiratory support, CO correlated neither with crSO2 nor with cFTOE.ConclusionIn compromised preterm neonates with lower gestational age and in need of respiratory support, CO was associated with crSO2 and cFTOE, whereas in stable preterm neonates with higher gestational age as well as in term neonates with and without respiratory support, no associations were observed.
Building connections through play: Influences on children's connected talk with peers
Authors: Goodacre Emily J. , Fink Elian , Ramchandani Paul , Gibson Jenny L. 
Published: March 2023

AbstractEffective reciprocal communication is a vital component in forming and maintaining social relationships. Peer social play may provide a particularly important context for communicative skill development, as sophisticated negotiation and exchange are required to coordinate play. We focus on connectedness, a property of conversation referring to the topical relation between speakers' turns, to understand how partners coordinate ideas to build a shared play experience. The present study uses a longitudinal secondary analysis approach to drive forward our understanding of the individual and shared influences that contribute to connectedness during peer social play. Using data from a three‐wave, longitudinal study of children's play and social relationships during the first 3 years of school in the United Kingdom (https://osf.io/3p4q8/), we coded connectedness from transcripts of video observations of 148 children playing in pairs at wave three (mean age 6.79 years) and model individual differences in language ability, theory of mind, and emotion comprehension from all three waves as potential predictors of connectedness. Our results show substantial dyadic effects on connectedness, but individual differences in socio‐cognitive measures were not significant predictors of connectedness. These findings indicate the importance of dyadic and partner effects in children's social interactions and implicate the dyad as an essential focus for future research.
Event‐related potential and behavioural evidence of goal‐based expectations for consistent actions among group members
Authors: Yin Jun , Zhou Dan , Ai Danfeng , Sun Hongli , Duan Jipeng , Sun Zhongqiang , Guo Xiuyan 
Published: March 2023

AbstractPlaceholder TextAbstractPeople expect group members to act consistently. However, because actions are organized hierarchically, incorporating deep‐level goals and shallow‐level movements, it remains unclear what level of action is expected to be consistent among group members. We determined that these two levels of action representations can be dissociated in object‐directed actions and measured the late positive potential (LPP), which indicates expectation. We found that participants identified a new agent's actions more quickly when this agent pursued a consistent goal while moving in a manner inconsistent with group members than when this agent pursued an inconsistent goal while moving in the same manner as group members. Moreover, this facilitation effect disappeared when the new agent was from a different group, revealing goal‐based expectations for consistent actions among group members. The LPP amplitude during the action‐expectation phase was greater for agents from the same group than for agents from a different group, suggesting that people implicitly generate clearer action expectations for group members than for other individuals. Additionally, the behavioural facilitation effect was observed when the goal of actions was clearly identifiable (i.e. performing rational actions to reach an external target) rather than when there was no clear association between actions and external targets (i.e. performing irrational actions). The LPP amplitude during the action‐expectation phase was greater after observing rational actions than after observing irrational actions performed by two agents from the same group, and the expectation‐related increase in LPP predicted the behavioural measurements of the facilitation effect. Hence, the behavioural and event‐related potential evidence suggest that people implicitly expect group members to behave consistently according to goals rather than movements per se.
Muscle pathology of antisynthetase syndrome according to antibody subtypes
Authors: Tanboon Jantima , Inoue Michio , Hirakawa Shinya , Tachimori Hisateru , Hayashi Shinichiro , Noguchi Satoru , Okiyama Naoko , Fujimoto Manabu , Suzuki Shigeaki , Nishino Ichizo 
Published: March 2023

AbstractIdentification of antisynthetase syndrome (ASS) could be challenging due to inaccessibility and technical difficulty of the serology test for the less common non‐Jo‐1 antibodies. This study aimed to describe ASS antibody‐specific myopathology and evaluate the diagnostic utility of myofiber HLA‐DR expression. We reviewed 212 ASS muscle biopsies and compared myopathologic features among subtypes. Additionally, we compared their HLA‐DR staining pattern with 602 non‐ASS myositis and 140 genetically confirmed myopathies known to have an inflammatory component. We used t‐test and Fisher's exact for comparisons and used sensitivity, specificity, positive and negative predictive values to assess the utility of HLA‐DR expression for ASS diagnosis. RNAseq performed from a subset of myositis cases and histologically normal muscle biopsies was used to evaluate interferon (IFN)‐signaling pathway‐related genes. Anti‐OJ ASS showed prominent myopathology with higher scores in muscle fiber (4.6 ± 2.0 vs. 2.8 ± 1.8, p = 0.001) and inflammatory domains (6.8 ± 3.2 vs. 4.5 ± 2.9, p = 0.006) than non‐OJ ASS. HLA‐DR expression and IFN‐γ‐related genes upregulation were prominent in ASS and inclusion body myositis (IBM). When dermatomyositis and IBM were excluded, HLA‐DR expression was 95.4% specific and 61.2% sensitive for ASS with a positive predictive value of 85.9% and a negative predictive value of 84.2%; perifascicular HLA‐DR pattern is common in anti‐Jo‐1 ASS than non‐Jo‐1 ASS (63.1% vs. 5.1%, p < 0.0001). In the appropriate clinicopathological context, myofiber HLA‐DR expression help support ASS diagnosis. The presence of HLA‐DR expression suggests involvement of IFN‐γ in the pathogenesis of ASS, though the detailed mechanisms have yet to be elucidated.
MicroRNA‐128 suppresses tau phosphorylation and reduces amyloid‐beta accumulation by inhibiting the expression of GSK3β, APPBP2, and mTOR in Alzheimer's disease
Authors: Li Siwen , Poon Chi Him , Zhang Zhigang , Yue Ming , Chen Ruijun , Zhang Yalun , Hossain Md. Farhad , Pan Yining , Zhao Jun , Rong Lei , Chu Leung Wing , Shea Yat Fung , Rogaeva Ekaterina , Tu Jie , St George‐Hyslop Peter , Lim Lee Wei , Song You‐Qiang 
Published: March 2023

AbstractIntroduction and AimsAlzheimer's disease (AD) is characterized by the abnormal accumulation of hyperphosphorylated tau proteins and amyloid‐beta (Aβ) peptides. Recent studies have shown that many microRNAs (miRNAs) are dysregulated in AD, and modulation of these miRNAs can influence the development of tau and Aβ pathology. The brain‐specific miRNA miR‐128, encoded by MIR128‐1 and MIR128‐2, is important for brain development and dysregulated in AD. In this study, the role of miR‐128 in tau and Aβ pathology as well as the regulatory mechanism underlying its dysregulation were investigated.MethodsThe effect of miR‐128 on tau phosphorylation and Aβ accumulation was examined in AD cellular models through miR‐128 overexpression and inhibition. The therapeutic potential of miR‐128 in AD mouse model was assessed by comparing phenotypes of 5XFAD mice administered with miR‐128‐expressing AAVs with 5XFAD mice administered with control AAVs. Phenotypes examined included behavior, plaque load, and protein expression. The regulatory factor of miR‐128 transcription was identified through luciferase reporter assay and validated by siRNA knockdown and ChIP analysis.ResultsBoth gain‐of‐function and loss‐of‐function studies in AD cellular models reveal that miR‐128 represses tau phosphorylation and Aβ secretion. Subsequent investigations show that miR‐128 directly inhibits the expression of tau phosphorylation kinase GSK3β and Aβ modulators APPBP2 and mTOR. Upregulation of miR‐128 in the hippocampus of 5XFAD mice ameliorates learning and memory impairments, decreases plaque deposition, and enhances autophagic flux. We further demonstrated that C/EBPα transactivates MIR128‐1 transcription, while both C/EBPα and miR‐128 expression are inhibited by Aβ.ConclusionOur findings suggest that miR‐128 suppresses AD pathogenesis, and could be a promising therapeutic target for AD. We also find a possible mechanism underlying the dysregulation of miR‐128 in AD, in which Aβ reduces miR‐128 expression by inhibiting C/EBPα.
Comparison of two distinct needle tip positions in pulsed radiofrequency for herpes zoster‐related pain
Authors: Li Shao‐jun , Feng Dan 
Published: March 2023

AbstractBackgroundHerpes zoster (HZ)‐related pain, characterized by chronic and persistent pain with a dermatomal distribution, is a relatively common complication of HZ. Pulsed radiofrequency (PRF) can effectively relieve HZ‐related pain. There is no study on the effect of the needle tip position in patients with HZ for PRF treatment. This prospective study was conducted to compare two distinct needle tip positions in PRF for HZ‐related pain.MethodsSeventy‐one patients suffering from HZ‐related pain were enrolled in this study. According to the dorsal root ganglion (DRG) position and needle tip position, patients were randomly allocated to the IP group (group inside of the pedicle, n = 36) and OP group (group outside of the pedicle, n = 35). Quality of life and pain control were evaluated with the visual analog scale (VAS) and activities of daily living questionnaires (including 7 items: general activity, mood, walking ability, normal work, relations with other people, sleep, and enjoyment of life), which were administered before therapy and at intervals of 1, 7, 30, and 90 days after therapy.ResultsBefore therapy, the mean pain score was found to be 6.03 ± 0.45 in the IP group and 6.00 ± 0.65 in the OP group (p = 0.555). No significant differences were found when the two groups were compared at 1 and 7 days after therapy (p > 0.05). But, the pain score was significantly lower in the IP group at 30 days (1.78 ± 1.31 vs. 2.77 ± 1.31, p = 0.006) and 90 days of follow‐up (1.29 ± 1.19 vs. 2.15 ± 1.74, p = 0.041). Significant differences between the two groups in terms of general activity (2.39 ± 0.87 vs. 2.86 ± 0.77, p = 0.035), mood (1.97 ± 1.65 vs. 2.86 ± 1.50, p = 0.021), relations with other people (1.94 ± 0.92 vs. 2.51 ± 1.22, p = 0.037), sleep (1.64 ± 1.44 vs. 2.97 ± 1.44, p < 0.001), and enjoyment of life (1.58 ± 1.11 vs. 2.43 ± 1.33, p = 0.004) were detected after the 30‐day follow‐up. In addition, scores for the activities of daily living were significantly lower in the IP group than that in the OP group at 90 days after therapy (p < 0.05).ConclusionThe needle tip position had an influence on the PRF treatment in patients with HZ‐related pain. Positioning the needle tip in the area between the medial and lateral edges of adjacent pedicles offered good pain relief and improved quality of life in HZ patients.
Serotonergic modulation of local network processing in V1 mirrors previously reported signatures of local network modulation by spatial attention
Authors: Patel Aashay M. , Kawaguchi Katsuhisa , Seillier Lenka , Nienborg Hendrikje 
Published: March 2023

AbstractSensory processing is influenced by neuromodulators such as serotonin, thought to relay behavioural state. Recent work has shown that the modulatory effect of serotonin itself differs with the animal's behavioural state. In primates, including humans, the serotonin system is anatomically important in the primary visual cortex (V1). We previously reported that in awake fixating macaques, serotonin reduces the spiking activity by decreasing response gain in V1. But the effect of serotonin on the local network is unknown. Here, we simultaneously recorded single‐unit activity and local field potentials (LFPs) while iontophoretically applying serotonin in V1 of alert monkeys fixating on a video screen for juice rewards. The reduction in spiking response we observed previously is the opposite of the known increase of spiking activity with spatial attention. Conversely, in the local network (LFP), the application of serotonin resulted in changes mirroring the local network effects of previous reports in macaques directing spatial attention to the receptive field. It reduced the LFP power and the spike–field coherence, and the LFP became less predictive of spiking activity, consistent with reduced functional connectivity. We speculate that together, these effects may reflect the sensory side of a serotonergic contribution to quiet vigilance: The lower gain reduces the salience of stimuli to suppress an orienting reflex to novel stimuli, whereas at the network level, visual processing is in a state comparable to that of spatial attention.
An empirical analysis of linguistic styles in new work services: The case of Fiverr.com
Authors: Brunzel Johannes 
Published: March 2023

AbstractCurrent online marketplaces, characterized by a high number of sellers and the velocity of offerings, make service differentiation difficult for sellers. One particularly promising avenue for sellers (in this study: individuals) beyond classical demand‐side approaches (i.e., prices) is to employ linguistic descriptions of their offerings. Yet, it remains mostly unclear what constitutes “successful” linguistic strategies. To elaborate on this, the current paper mines more than 2000 unique service offerings on Fiverr.com, a leading online marketplace for freelance services. By distinguishing between different service categories (i.e., hedonic and utilitarian services) and other characteristics of individual sellers (e.g., the origin of a seller), the paper analyzes the linguistic service descriptions via the Linguistic Inquirer and Word Counts (LIWC) and provides an empirical taxonomy of linguistic styles among individuals. Although the paper is novel and explorative, a few interesting insights can be obtained. First, there are significant linguistic differences in how sellers describe their service offerings depending on the service category (hedonic/utilitarian). Second, linguistic proxies of complexity, namely, words per sentence, six‐letter words, and the overall word count (i.e., increasing informational content) as well as signals of analytical language, appear to be a beneficial strategy for sellers. Third, a linguistic strategy aimed at matching (congruence) of service categories (hedonic/utilitarian) and linguistic styles (analytical/emotional) appears to be beneficial. The results have important implications for creating linguistic strategies in online marketplaces focused on services on the supply side.