bluuebunny/crossref_metadata_2025_split huggingface dataset:
A new method and application of groundwater prediction along the direction of tunnel excavation in karst strata
Authors: Lou Guochong , Song Yang , Man Lingcong , Sun Zhitao 
Published: July 2023

Abstract

Tunnel construction in karst strata with abundant water causes changes in the surrounding groundwater environment, which can easily trigger geological disasters such as mud and water inrush. How to accurately predict the groundwater ahead of tunnel excavation face is a highly challenging problem. In order to improve the detection accuracy of groundwater during the construction of a deep buried tunnel, the transmission and reflection process of seismic waves at the interface and the relationship between the reflection coefficient and seismic wave signal have been analyzed on the basis of a two-phase medium theory in this paper. The expression of seismic wave stress–response relationship associated with the instantaneous amplitude and instantaneous phase and frequency is established. Then the relationship between seismic wave attributes and groundwater seepage potential energy is derived by combining the fluid mechanics theory, which is used as the basis for the determination and identification of groundwater volume and classified, and a new technology of an advanced detection of groundwater by seismic waves is established. This method has been applied to the Zhanghuai Railway in China and quantitatively predicted the karst water and caves in the Tianqiaoshan Tunnel before excavation. The engineering test proves the reliability and advancement of this technology.
Analysis of sampling strategies for pulse loads of SARS-CoV-2: implications for wastewater-based epidemiology
Authors: König Albert Wilhelm , Ariano Sarah Sydney , Joksimovic Darko 
Published: July 2023

Abstract

A faecal transport model was applied to a 11.3 km2 wastewater servicing area in Toronto, Ontario, Canada to explore the role that different wastewater sampling campaigns have on estimating the prevalence of SARS-CoV-2 in a population of 60,000. A stochastic wastewater and water quality model was used to evaluate the effectiveness of 11 sampling campaigns during periods of high and low COVID-19 infection among the population, tested using virtual sampling during dry-weather flow. The virtual sampling campaigns were based on the most common automatic sampler programming capabilities and widely used wastewater-based epidemiology (WBE) sampling campaigns reported in the literature. Sampling campaigns differ in weighting method (time, volume, or flow-weighted sampling), sample count, collection period, or sample time. Results suggest that grab samples should be avoided and/or that sampling campaigns with the greatest sample counts and durations are the most robust at capturing COVID-19 infection among the population. Most surprisingly, changes to the weighting method were negligible indicating that a greater number of samples, and larger sample volumes are preferred. This work suggests that investment in flow monitoring equipment for flow- or volume-weighted sampling will not improve WBE results, and that standard time based sampling is sufficient.
SNHG3/miR-330-5p/HSD11B1 Alleviates Myocardial Ischemia-reperfusion
Injury by Regulating the ERK/p38 Signaling Pathway
Authors: Bai Xiaochuan , Zhang Jie , Yang Heyun , Linghu Keqiang , Xu Min 
Published: July 2023

Background:
Studies have found that microRNAs (miRNAs) participate in the pathogenesis
of myocardial ischemia-reperfusion injury (MIRI). miR-330-5p alleviated cerebral IR injury
and regulated myocardial damage. However, the mechanism of the effect of miR-330-5p on MIRI
needs to be further studied.

Objective:
The study aimed to explore the role and mechanism of miR-330-5p in MIRI.

Methods:
The oxygen-glucose deprivation reperfusion (OGD/R) model was constructed in cardiomyocytes
to simulate MIRI in vitro. QRT-PCR was used for the detection of gene expression.
ELISA was used for evaluation of the levels of aldehyde dehydrogenase 2 family member (ALDH2),
4-hydroxynonenal (4-HNE), and malondialdehyde (MDA). Flow cytometry was used to evaluate
apoptosis. Western blot was employed for protein determination. Bioinformatic analysis was
performed for predicting the targets of miR-330-5p.

Results:
miR-330-5p was found to be down-regulated in MIRI-induced cardiomyocytes (Model
group). miR-330-5p mimic enhanced ALDH2 activity, inhibited apoptosis, and suppressed 4-HNE
and MDA of MIRI-induced cardiomyocytes. miR-330-5p inhibited ERK expression while increasing
the p38 expression. Bioinformatic analysis showed hydroxysteroid 11-beta dehydrogenase 1
(HSD11B1) to be a target of miR-330-5p. HSD11B1 expression was inhibited by miR-330-5p mimic
while increased by miR-330-5p inhibitor in MIRI-induced cardiomyocytes. HSD11B1 overexpression
reversed the effect of miR-330-5p on ALDH2, 4-HNE, MDA, apoptosis, and ERK/p38
signaling pathway. Furthermore, lncRNA small nucleolar RNA host gene 3 (SNHG3) was the upstream
lncRNA of miR-330-5p. SNHG3 decreased miR-330-5p expression and increased HSD11B1
expression.

Conclusion:
SNHG3/miR-330-5p alleviated MIRI in vitro by targeting HSD11B1 to regulate the
ERK/p38 signaling pathway.
Cinnamaldehyde as a Promising Dietary Phytochemical Against Metabolic
Syndrome: A Systematic Review
Authors: Khaafi Mohaddeseh , Tayarani-Najaran Zahra , Javadi Behjat 
Published: July 2023

Background:
Metabolic syndrome (METS) is a set of unhealthy medical conditions
considered essential health problems today. Cinnamaldehyde (CA) is the major phytochemical
present in the essential oil of cinnamon and possesses antioxidant, anti-inflammatory, hypoglycemic,
and antihyperlipidemic activities.

Aim:
We aim to systematically review the effects of CA in preventing and attenuating METS
components. Moreover, the cellular and molecular mechanisms of actions of CA, its pharmacokinetics
features, and potential structure-activity relationship (SAR) were also surveyed.

Methods:
PubMed, Science Direct, Scopus, and Google Scholar were searched to retrieve the relevant
papers.

Results:
CA possesses various anti-METS activities, including anti-inflammatory, antioxidant,
antidiabetic, antidyslipidemia, antiobesity, and antihypertensive properties. Various molecular
mechanisms such as stimulating pancreatic insulin release, exerting an insulinotropic effect, lowering
lipid peroxidation as well as pancreatic islet oxidant and inflammatory toxicity, increasing
the activities of pancreatic antioxidant enzymes, suppressing pro-inflammatory cytokines production,
regulating the molecular signaling pathways of the PPAR-γ and AMPK in preadipocytes and
preventing adipocyte differentiation and adipogenesis are involved in these activities.

Conclusions:
CA would effectively hinder METS; however, no robust clinical data supporting
these effects in humans is currently available. Accordingly, conducting clinical trials to evaluate
the efficacy, safe dosage, pharmacokinetics characteristics, and possible unwanted effects of CA
in humans would be of great importance.
Linc01116 Silencing Inhibits the Proliferation and Invasion,
Promotes Apoptosis of Chordoma Cells via Regulating the
Expression of Mir-9-5p/PKG1
Authors: Liu Junqi , Qi Yan , Hou Siyuan , Zhang Siyuan , Wang Zhenlin 
Published: July 2023

Background:
Long intergenic non-protein coding RNA 1116 (LINC01116)
plays a carcinogenic role in a variety of cancers. The study aims to investigate the roles
of LINC01116 and hsa-miR-9-5p (miR-9-5p) and fathom their interaction in chordoma.

Methods:
The predicted binding sites between miR-9-5p with LINC01116 and
phosphoglycerate kinase 1 (PGK1) by starBase were confirmed through dual-luciferase
reporter assay. The behaviors of chordoma cells undergoing transfection with
siLINC01116 or miR-9-5p inhibitor were determined by Cell Counting Kit-8 (CCK-8),
colony formation, Transwell, and flow cytometry assays. The glucose consumption,
lactate production, and adenosine triphosphate (ATP) production of chordoma cells were
examined with specific kits. Quantitative real-time polymerase chain reaction (qRT-PCR)
and Western blot were performed to determine relevant gene expressions in chordoma
cells.

Results:
Silencing of LINC01116 facilitated the apoptosis and expressions of Bcl-2-
associated X (Bax), cleaved caspase-3 (C caspase-3) and miR-9-5p while repressing
the cell cycle, viability, proliferation, invasion, glucose consumption, lactate production,
ATP production, and expressions of PGK1 and Bcl-2. Meanwhile, LINC01116 sponged
miR-9-5p, which could target PGK1. Moreover, the miR-9-5p inhibitor acted contrarily
and reversed the role of siLINC01116 in chordoma cells. Besides, LINC01116
downregulation facilitated apoptosis and attenuated the proliferation and invasion of
chordoma cells as well as PGK1 expression by upregulating miR-9-5p expression.

Conclusion:
LINC01116/miR-9-5p plays a regulatory role in the progression of
chordoma cells and is a potential biomarker for chordoma.
The Metabolic Basis for Nervous System Dysfunction in Alzheimer’s
Disease, Parkinson’s Disease, and Huntington’s Disease
Authors: Maiese Kenneth 
Published: July 2023

Abstract:
Disorders of metabolism affect multiple systems throughout the body but may have the
greatest impact on both central and peripheral nervous systems. Currently available treatments and
behavior changes for disorders that include diabetes mellitus (DM) and nervous system diseases
are limited and cannot reverse the disease burden. Greater access to healthcare and a longer
lifespan have led to an increased prevalence of metabolic and neurodegenerative disorders. In light
of these challenges, innovative studies into the underlying disease pathways offer new treatment
perspectives for Alzheimer’s Disease, Parkinson’s Disease, and Huntington’s Disease. Metabolic
disorders are intimately tied to neurodegenerative diseases and can lead to debilitating outcomes,
such as multi-nervous system disease, susceptibility to viral pathogens, and long-term cognitive
disability. Novel strategies that can robustly address metabolic disease and neurodegenerative disorders
involve a careful consideration of cellular metabolism, programmed cell death pathways,
the mechanistic target of rapamycin (mTOR) and its associated pathways of mTOR Complex 1
(mTORC1), mTOR Complex 2 (mTORC2), AMP-activated protein kinase (AMPK), growth factor
signaling, and underlying risk factors such as the apolipoprotein E (APOE-ε4) gene. Yet, these
complex pathways necessitate comprehensive understanding to achieve clinical outcomes that target
disease susceptibility, onset, and progression.
Degradation of LDPE Using the Winogradsky Column Containing Otteri
Dumpsite Soil: Prediction of Mechanism and Metabolites Determination
Authors: Sridharan Rajalakshmi , Sivamurugan Vajiravelu , Kumar P. Senthil , K. Veena Gayathri , Rangasamy Gayathri 
Published: July 2023

Background of the Research:
Plastic pollution has taken over the world. Toxicity of the plastics
and other pollutants is enhanced due to the formation of microplastics and nano-plastics that attract
Persistent Organic Pollutants (POPs). The need for the treatment of plastic waste in the current scenario
led to the rise of various treatment processes. Biodegradation, an eco-friendly approach to eliminate plastics
urged to discover plastic-utilizing bacteria and plastic-eating worms. Bacterial degradation of plastics
has been extensively studied utilizing the entire microbial community. Hence, the current research focuses
on the biodegradation of Low-Density polyethylene (LDPE) using Winogradsky Column constructed
using dump yard soil. LDPE degradation was determined using FTIR and GC-MS analysis, which is used
to analyze the degradation mechanism of LDPE.

Methods:
Sample Collection and Column Construction: The soil samples collected from the Chennai
dump yard were used to construct Winogradsky columns. The column with LDPE and enrichment
sources is used to study LDPE degradation.

Analysis of LDPE Degradation:
The LDPE sheet after incubation was washed with surfactant and ethanol.
The dried sheet was analyzed for weight loss and the metabolites were identified using GC-MS analysis.
The GC-MS chromatogram was used to determine the pattern of degradation by the microbial community
in the dump yard soil.

Results:
The mass spectral analysis of GC peaks has been carried out using the electron ionization method,
and ions were detected using positive ions scanning mode. The GC peaks appeared at 22.532 and 23.117 min
in the control LDPE sheet, which was found to be nonadecane and octacosane, whereas, in the treated LDPE
sheet, the GC peaks appeared at 22.467 and 23.062 min. The fragmentation pattern indicates the loss of m/z
14, which confirms the loss of methylene (-CH2-) fragments in alkyl chains. The difference in retention time
could be correlated with the increase of CH2 in the alkyl chain length and molecular weight. Higher molecular
weight alkanes, such as C16, C18, and C20 above appeared at higher retention times. The presence of
longer alkyl chains indicates the LDPE polymer chains. The treated LDPE sample has been analyzed, and
the fragmentation pattern indicates the presence of aliphatic chains of C16 or C18.

Conclusion:
The current study provides an efficient method to utilize the microbial community as a
whole to degrade LDPE. The degradation mechanism of LDPE was determined using GC-MS analysis.
The high molecular weight polymeric chain was degraded to small chains, and the formation of alcohol
indicates the occurrence of terminal oxidation. Hence, this confirms the degradation of LDPE by the microbiome
present in the dump yard soil.
Erythema Multiforme Reactions Following Pfizer/BioNTech (Tozinameran)
Vaccination: Two Case-Reports with Positive Rechallenge and Review of
the Literature
Authors: Charfi Ons , Lakhoua Ghozlane , Berrim Khouloud , Kastalli Sarrah , Badri Talel , Aouinti Imen , Daghfous Riadh , Zaiem Ahmed , Aidli Sihem EL 
Published: July 2023

Aim:
Pfizer/BioNTech (BNT162b2) is a COVID-19 vaccine with a reassuring safety
profile. The main adverse reactions are mild local reactions. Cutaneous reactions are generally
minor. The most common cutaneous reaction reported was a local injection-site reaction.

Case Study:
Here we present 2 cases of erythema multiform (EM) following BNT162b2 vaccination
with positive rechallenge. The 1st case was about a 51-year-old woman who developed 5 days
after the 1st dose of the mRNA Pfizer/BioNTech (BNT162b2) a macular, erythematous, roundshaped
lesions on the hands, knees and soles. She experienced a positive rechallenge one month
later.

:
In the 2nd case, a 55-year-old man presented 6 days following the 2nd shot of the mRNA Pfizer/
BioNTech (BNT162b2), targetoid eruption on the upper and lower members. The patient reported
that he had the same skin lesions in ankles and soles few days following the 1st shot of the same
vaccine.

Conclusion:
Few cases of EM following COVID-19 vaccination were reported in the literature and
positive rechallenge in only one case. Rechallenge was not performed in most cases.

:
Our two cases are particular because of the positive rechallenge in both patients. This is the gold
standard to confirm that the vaccine was the culprit agent in inducing EM.
A Mini Review on the Application of Chitosan Composites for the
Adsorption of Fluoride from Aqueous Solution
Authors: Sutherland Clint , Chittoo Beverly , Islam Abdel 
Published: July 2023

Background:
Exploration into the development of cost-effective and eco-friendly adsor-bents for the removal of fluoride continues to be unabated. The modification of chitosan through the development of composites and derivatives has shown great promise over the past decade. These modifications aim to overcome the limitation of chitosan, such as separability and adsorption capacity.

Objectives:
The objective of this study is to review various modifications to chitosan for defluorida-tion, the resulting adsorption capacities, operational parameters that appreciably influence the full-scale application of adsorption systems and, where reported, the mechanisms that influenced the ad-sorption process.

Results and Discussion:
Among the adsorbents reviewed, most of the processes were best modelled by the Langmuir isotherm and the pseudo-second order model. Chitosan composites were able to achieve significantly higher F- adsorption capacities and compared well to other adsorbents in the literature. Gamma degraded chitosan-Fe(III) beads, 10%-Lanthanum-incorporated chitosan beads and neodymium-modified chitosan were found to easily achieve the WHO drinking water limit of 1.5 mg/L. In all instances, the reactions were spontaneous and endothermic. Fluoride adsorption was shown to increase from the acidic region to near neutral pH followed by a decrease into the al-kaline range.

Conclusion:
The presence of competing ions is a major operational parameter for full-scale adsorp-tion applications. The presence of carbonate and bicarbonate ions has been a consistent hindrance in reported studies. Thus, future investigations are warranted in this area.
Development and Testing of a Mobile App to Collect Social Determinants of Health Data in Cancer Settings: Interview Study
Authors: Oyedele Natasha K , Lansey Dina G , Chiew Calvin , Chan Cupid , Quon Harry , Dean Lorraine T 
Published: July 2023

Background
Social determinants of health (SDOH) such as lack of basic resources, housing, transportation, and social isolation play an important role for patients on the cancer care continuum. Health systems’ current technological solutions for identifying and managing patients’ SDOH data largely focus on information recorded in the electronic health record by providers, which is often inaccessible to patients to contribute to or modify.

Objective
We developed and tested a patient-centric SDOH screening tool designed for use on patients’ personal mobile phone that preserves patient privacy and confidentiality, collects information about the unmet social needs of patients with cancer, and communicates them to the provider.

Methods
We interviewed 22 patients with cancer, oncologists, and social workers associated with a US-based comprehensive cancer center to better understand how patients’ SDOH information is collected and reported. After triangulating data obtained from thematic analysis of interviews, an environmental scan, and a literature search of validated tools to collect SDOH data, we developed an SDOH screening tool mobile app and conducted a pilot study of 16 dyadic pairs of patients and cancer care team members at the same cancer center. We collected patient SDOH data using 36 survey items covering 7 SDOH domains and used validated scales and follow-up interviews to assess the app’s usability and acceptability among patients and cancer care team members.

Results
Formative interviews with patients and care team members revealed that transportation, financial challenges, food insecurity, and low health literacy were common SDOH challenges and that a mobile app that collected those data, shared those data with care team members, and offered supportive resources could be useful and valuable. In the pilot study, 25% (4/16) of app-using patients reported having at least one of the abovementioned social needs; the most common social need was social isolation (7/16, 44%). Patients rated the mobile app as easy to use, accurately capturing their SDOH, and preserving their privacy but suggested that the app could be more helpful by connecting patients to actual resources. Providers reported high acceptability and usability of the app.

Conclusions
Use of a brief, patient-centric, mobile app–based SDOH screening tool can effectively capture SDOH of patients with cancer for care team members in a way that preserves patient privacy and that is acceptable and usable for patients and care team members. However, only collecting SDOH information is not sufficient; usefulness can be increased by connecting patients directly to resources to address their unmet social needs.
Sociology as a Theory of Conflict
Authors: Kumankov A. D. 
Published: July 2023

Журнальный номер о конфликте как социальном феномене не может дать исчерпывающего теоретического и эмпирического исследования конфликта. Мы ставили перед собой цель дать обзор значимых новейших теорий конфликта и отрефлексировать некоторые аспекты современной социальной практики. Результаты этой работы мы предлагаем вашему вниманию.
Nilai Kesederhanaan Abdul Rozak Fachruddin sebagai Tauladan Bagi Generasi Z Dan Post Gen Z
Authors: Saputra Erwin , Purnomo Budi , Wahyuni Anny 
Published: July 2023

Abdul Rozaq Fachruddin adalah tokoh yang dapat kita sematkan sebagai tauladan dalam menjalani kehidupan. Pak A.R. mempunyai sifat dan sikap menjadi manusia yang seutuhnya. Menjali hidup dengan kesederhanaan menjadi kunci pribadi manusia yang tidak dibebani dengan keduniawian. Pak A.R. mencontohkan bahwa materi dunia bukan jembatan menuju kehidupan yang bersahaja. Dakwah kultural yang dilakukan oleh A.R. Fachruddin menjadi kunci penerimaan di tengah masyarakat. Tujuan dari penelitian ini adalah memberikan gambaran keadaan tokoh A.R. Fachruddin yang menjalani kehidupannya dengan kesederhanaan. Kondisi tersebut patut dicontoh oleh generasi Z (lahir tahun 1997-2012) maupun generasi Post Gen Z (Kelahiran 2013 ke atas). Data dikumpulkan melalui pendekatan kualitatif dan metode Sejarah. Kajian ini melihat generasi yang akan menjadi pemimpin di kemudian hari ini sebagai regenerasi generasi sebelumnya patut meneladani pribadi AR Fachruddin ini. Adapun kesederhanaan yang harus dicontoh antara lain: (1) pribadi yang entengan, (2) gemar bederma, (3) sederhana, supel, dan ikhlas, (4) bersahaja, jujur, dan toleran.
KAJIAN PROSES ISLAMISASI DI NUSANTARA (STUDI ANALISIS MASJID AL – MUBAROK DI DESA KACANGAN KECAMATAN BERBEK, KABUPATEN NGANJUK)
Authors: Enda Tita Nur , Listanti Yurisda , Sukma M Mochamad , Wiratama Nara Setya 
Published: July 2023

Penelitian ini dilatarbelakangi oleh banyaknya media penyebaran Islam di Nusantara, dan proses islamisasi yang terjadi di wilayah Kabupaten Nganjuk dengan keberadaan masjid Al-Mubarok. Didirikan pada tahun 1831 Masehi oleh K.R.T Sosrokoesoemo I atau lebih di kenal dengan Kanjeng Jimat. Tujuan dari penelitian ini guna mengetahui sejarah berdirinya Masjid Al-Mubarok, dan Struktur bangunan Masjid Al-Mubarok. Penelitian ini menggunakan metode deskriptif kualitatif dengan cara mendeskripsikan, menganalisis, dan membandingkan informasi dari hasil pengamatan keadaan dilapangan dengan kajian pustaka dari sumber resmi lainnya. Hasil dari penelitian ini yaitu Masjid Al-Mubarok sebagai masjid tertua sekaligus bangunan bersejarah di wilayah Kabupaten Nganjuk yang menjadi media Islamisasi di wilayah Kabupaten Nganjuk. Berdasarkan hasil tersebut dapat disimpulkan pengaruh Islam di Kabupaten Nganjuk berkembang sangat pesat, mengubah mayoritas kepercayaan masyarkat Kabupaten Nganjuk dari Hindu-Buddha menuju Islam sejak berdirinya masjid Al-Mubarok.
PENANAMAN NILAI-NILAI NASIONALISME SISWA MELALUI PEMBELAJARAN SEJARAH DARI PERISTIWA PERTEMPURAN 10 NOVEMBER DI SURABAYA
Authors: Muwafiq Ahmad 
Published: July 2023

Tulisan ini membahas mengenai nilai-nilai nasionalisme yang dapat diambil dan diterapkan kepada siswa melalui pembelajaran sejarah dari peristiwa pertempuran 10 November di surabaya. Penelitian ini bertujuan untuk mengidentifikasi nilai-nilai apa saja yang dapat diambil dan diterapkan kepada siswa dari peristiwa pertempuran 10 November di surabaya dan bagaimana cara menerapkannya melalui pembelajaran sejarah disekolah. Pendekatan penelitian yang digunakan dalam Penelitian ini adalah pendekatan kualitatif, pendekatan kualitatif dan jenis penelitian dalam penelitian ini adalah penelitian pustaka atau library research. Hasil dari penelitian ini menunjukan bahwa nilai-nilai yang dapat diambil dan diterapkan kepada siswa dari peristiwa pertempuran 10 November di surabaya antara lain: cinta tanah air, jujur, bekerja keras, peduli, tanggung jawab, peduli lingkungan, rasa ingin tahu, semangat kebangsaan, rela berkorban, mandiri, demokratis, disiplin, jujur, dan religius.