bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reproduction patterns among classical Hodgkin lymphoma survivors treated with BEACOPP and ABVD in Sweden, Denmark and Norway—A population‐based matched cohort study
Authors: Entrop Joshua P. , Weibull Caroline E. , Smedby Karin E. , Jakobsen Lasse H. , Øvlisen Andreas K. , Molin Daniel , Glimelius Ingrid , Marklund Anna , Holte Harald , Fosså Alexander , Smeland Knut B. , El‐Galaly Tarec C. , Eloranta Sandra 
Published: April 2023

AbstractChildbirth rates in classical Hodgkin lymphoma (cHL) survivors have historically been reduced compared to the general population. Understanding if contemporary treatment protocols are associated with reduced fertility is crucial as treatment guidelines shift toward more liberal use of intensive chemotherapy. We identified 2834 individuals aged 18‐40 years with cHL in Swedish and Danish lymphoma registers, and in the clinical database at Oslo University Hospital diagnosed 1995‐2018, who were linked to national medical birth registers. Cox regression adjusted for stage, performance status, year, and age at diagnosis was used to estimate hazard ratios (HRs) and 95% confidence intervals (CI) contrasting time to first childbirth by treatment groups (ABVD, 2‐4 BEACOPP, 6‐8 BEACOPP) up to 10 years after diagnosis. Overall, 74.8% of patients were treated with ABVD, 3.1% with 2‐4 BEACOPP and 11.2% with 6‐8 BEACOPP. Adjusted HRs comparing childbirth rates in individuals treated with 6‐8 BEACOPP, and 2‐4 BEACOPP to ABVD were 0.53 (CI: 0.36‐0.77) and 0.33 (CI: 0.12‐0.91) for males, and 0.91 (CI: 0.61‐1.34) and 0.38 (CI: 0.12‐1.21) for females. Cumulative incidence of childbirths after 10 years was 19.8% (CI: 14.5%‐27.0%) for males and 34.3% (CI: 25.8%‐45.6%) for females treated with 6‐8 BEACOPP. Proportions of children born after assisted reproductive technique (ART) treatments were 77.4% (CI: 60.2‐88.6%) for males following 6‐8 BEACOPP, and <11% for females. Among ABVD treated patients the corresponding proportions were 12.2% (CI: 8.5%‐17.3%) and 10.6% (CI: 7.4%‐14.9%). BEACOPP treatment is associated with decreased childbirth rates compared to ABVD in male, but not female, cHL patients, despite widespread access to ART in the Nordics.
Impacts of disrespectful care and abusive care practices in maternity units and potential interventions to improve the quality of care in low‐ and middle‐income countries: A narrative review
Authors: Amathullah Ahamad Salman , Rishard Mohamed , Walpita Yasaswi 
Published: April 2023

AbstractThis review article explored the impacts of disrespectful care and abusive care practices and the potential interventions to eliminate those practices. Respectful maternity care is a fundamental right for all women. It ensures that women are able to exercise their rights in maternity care. However, research studies have shown the recent prevalence of poor‐quality care for women in maternity units in low‐ and middle‐income countries. The literature on this topic was searched on PubMed, Medline, Google Scholar, Cochrane, Science Direct/ Elsevier, and SCOPUS. A total of 24 qualitative and quantitative research articles were included. Thematic analysis was conducted by using the six steps. Impacts are coded on topics including psychological impacts due to disrespectful and abusive care practices, impact on the care process, normalization of the absence of care, suppression of knowledge regarding the labor process, and poor obstetric outcomes. Interventions are coded on topics including programs for health professionals to improve care, education and empowerment programs targeting the women and community, enacting policies and guidelines regarding disrespectful and abusive care practices and improving the facilities in the healthcare system. The majority of the evidenced‐based interventions were multi‐component and tailored to the needs of a particular setting. More research evidence is needed to inform the healthcare authorities and policymakers to transform these potential interventions into practice. Future research should clearly document the effectiveness of various combinations of interventions, feasibility, cost‐effectiveness, and outcomes.
Intrapartum ultrasound for fetal head asynclitism: Is it possible to establish a degree of asynclitism to correlate to delivery outcome?
Authors: Birol Ilter Pinar , Yassa Murat , Timur Hakan , Dogan Ozan , Tekin Arzu Bilge , Haydar Ahmad , Gulumser Cagri , Tug Niyazi , Malvasi Antonio , Tinelli Andrea 
Published: April 2023

AbstractObjectiveTo investigate the role of intrapartum ultrasound (IU) in the diagnosis of asynclitism and the importance of asynclitism degree in labor outcomes.MethodThis prospective cohort study included 41 low‐risk pregnant women with fetus in singleton‐vertex. The IU assessment to diagnose asynclitism was performed during labor at two specific steps, including the suspicion and/or diagnosis of labor arrest. The “four‐chamber view” and “squint sign without nose” were classified as marked/severe asynclitism. The “midline deviation” and “squint sign with nose” findings were classified as moderate asynclitism. Obstetric outcomes and maternal‐fetal complications were compared with the degree of asynclitism.ResultsSevere and moderate asynclitism was seen in 17 (41.7%), 10 (58.8%) and seven (41.2%) women, respectively. All pregnant women diagnosed with asynclitism delivered by vacuum extraction (VE) or cesarean section (CS). CS was performed in nine patients with asynclitism (52.9%). The difference between asynclitism type and VE/CS ratios was statistically significant (P = 0.039). Four fetuses with squint sign without nose delivered by VE. A significant correlation was seen between the presence of squint without nose sign and second−/third‐degree perineal injury.ConclusionSevere asynclitism is associated with increasing operative birth and maternal‐fetal complications. Detection of asynclitism degree by IU could be useful, alerting the obstetrics team to possible perinatal problems during delivery.
A case of testicular cancer with retroperitoneal lymph node metastasis of teratoma with somatic‐type malignancy 18 years after initial treatment
Authors: Yamashita Maiko , Sakai Takanari , Yamashita Shinichi , Fujishima Fumiyoshi , Goto Takuro , Sato Takuma , Kawasaki Yoshihide , Kawamorita Naoki , Tanaka Takaki , Ito Akihiro 
Published: April 2023

IntroductionIn testicular cancer, late relapse of teratoma with somatic‐type malignancy is rare and associated with a poor survival. A case of retroperitoneal lymph node metastasis of teratoma with somatic‐type malignancy 18 years after initial treatment for testicular cancer is reported.Case presentationA 46‐year‐old man had a 15‐mm‐sized mass in the para‐aortic region 18 years after initial treatment for testicular cancer, without elevated serum alfa‐fetoprotein or human chorionic gonadotropin levels. Laparoscopic retroperitoneal lymph node dissection was performed. The pathological findings showed teratoma with somatic‐type malignancy, and the findings of primary testicular cancer reported a yolk sac tumor, not teratoma.ConclusionLate relapse of teratoma with somatic‐type malignancy was resected by laparoscopic retroperitoneal lymph node dissection. Therefore, long‐term follow‐up should be considered if patients with small retroperitoneal masses did not undergo retroperitoneal lymph node dissection, and early detection and surgical resection for relapse might be effective.
“Every day do something that won't compute”: Student perceptions of daily poetry practice
Authors: Davis Megan 
Published: April 2023

AbstractThis article considers high school students' relationship to poetry through a small‐scale qualitative study guided by the question: what happens to student perceptions of poetry when class begins each day with a poem? As a former teacher and current teacher educator, I conducted a series of interviews with a small group of my former students regarding their experiences with poetry throughout their K‐12 education and with hearing a poem each day in their high school English Language Arts classroom. I sought to explore the dimensions and possibilities of non‐analytical literacy practices in addition to student perceptions of poetry as they relate to schooling contexts more broadly.
Evaluation of in vitro cytotoxic and genotoxic effects of the 3‐(3,4‐dihydroxyphenyl)‐8‐hydroxycoumarin
Authors: dos Santos Silva Edvannia , Matos Maria João , Maistro Edson Luis 
Published: April 2023

AbstractA wide variety of natural and synthetic coumarins present therapeutic potential. Therefore, the assessment of their safety for humans is essential. 3‐(3,4‐Dihydroxyphenyl)‐8‐hydroxycoumarin is a coumarin derivative with antioxidant properties, among other biological activities. The aim of this study is to evaluate the cytotoxic and genotoxic potential of this molecule on peripheral blood mononuclear cells (PBMC) and human hepatocellular carcinoma cells (HepG2/C3A). The results obtained for the cytotoxicity assays, evaluated by the trypan blue staining assay, using concentrations between 0.1 and 20 μg/mL, showed that there is no decrease in cell viability for both cell lines. The MTT assay showed a significant decrease in the viability of HepG2/C3A cells at the highest concentrations tested, after 48 h, for all the tested concentrations, after 72 h of exposure. Regarding the genotoxic assays, the data obtained by the comet assay and the micronucleus test, up to the tested concentration of 10 μg/mL, do not show significant DNA damage and/or chromosomal mutations, for both cell lines. However, at the highest tested concentration of 20 μg/mL, a small but significant genotoxic effect was observed in PBMC. In view of the observed results, it can be concluded that the 3‐(3,4‐dihydroxyphenyl)‐8‐hydroxycoumarin, up to a concentration of 10 μg/mL, does not present genotoxic effects in human cells with and without liver enzymes metabolism. Additional studies with higher concentrations of this molecule need to be performed to address its complete biosafety.
Coordination of noble gases by alkali‐metal‐like superatom cationBe3B+
Authors: Yashmin Farnaz , Mazumder Lakhya J. , Sharma Rohan , Sharma Pankaz K. 
Published: April 2023

AbstractQuantum chemical calculations were carried out to investigate the noble gas binding ability of Be3B+cluster. Calculations reveal that heavier noble gas atoms (ArXe) form stable complexes with this cluster. Detailed bonding analyses reveal that the noble gas atoms act as donor fragment in the formation of Ng → Be donor–acceptor bonds. Three noble gas atoms can consecutively form bonds with the Be atom of the Be3B+cluster.
Assessment of fetal pulmonary artery Doppler indices in pregnant women with rheumatoid arthritis and ankylosing spondylitis
Authors: Menekse Beser Dilek , Oluklu Deniz , Uyan Hendem Derya , Yildirim Muradiye , Serbetci Hakkı , Kara Ozgur , Sahin Dilek 
Published: April 2023

AbstractPurposeTo investigate fetal pulmonary artery Doppler parameters in pregnant women with rheumatoid arthritis (RA) and ankylosing spondylitis (AS).MethodsThis case–control study included 24 pregnant women diagnosed with 13 AS and 11 RA and 48 healthy pregnant women at 29–30 weeks of gestation. The demographic and clinical features were recorded, including disease type and duration, attacks during pregnancy, and medications. Pulmonary artery acceleration time (AT), ejection time (ET), and pulmonary artery acceleration time to ejection time (PATET) ratio were measured by manual trace with spectral Doppler ultrasound.ResultsA shorter pulmonary AT and lower PATET ratio were found in the case group (34.8 ± 2.3, p < 0.001, 0.18 ± 0.02, p < 0.001, respectively). When comparing the groups that had an attack during pregnancy and had not, there were no significant differences in the pulmonary artery indices. We also demonstrated a moderate correlation between maternal disease years and the PATET ratio (r = −0.562, p = 0.004).ConclusionThis is the first study to evaluate the effect of RA and AS on fetal pulmonary indices. Maternal inflammation might affect pulmonary development and circulation. Fetal pulmonary Doppler indices can be used to obtain further information about neonatal respiratory morbidities in rheumatological disorders.
Biochar addition reduces non‐CO2 greenhouse gas emissions during composting of human excreta and cattle manure
Authors: Castro‐Herrera Daniela , Prost Katharina , Kim Dong‐Gill , Yimer Fantaw , Tadesse Menfese , Gebrehiwot Mersha , Brüggemann Nicolas 
Published: April 2023

AbstractEcological sanitation combined with thermophilic composting is a viable option to transform human excreta into a stabilized, pathogen‐free, and nutrient‐rich fertilizer. In combination with suitable bulking materials such as sawdust and straw, and additives such as biochar, this could also be a suitable waste management strategy for reducing greenhouse gas (GHG) emissions. In this study, we conducted a 143‐days thermophilic composting of human excreta or cattle manure together with teff straw, organic waste, and biochar to investigate the effect that biochar has on GHG (CO2, N2O, and CH4) and NH3 emissions. The composting was performed in wooden boxes (1.5 × 1.5 × 1.4 m3), GHG were measured by using a portable FTIR gas analyzer and NH3 was sampled as ammonium in an H2SO4 trap. We found that the addition of biochar significantly reduced CH4 emissions by 91% in the cattle manure compost, and N2O emissions by 56%−57% in both humanure and cattle manure composts. Overall, non‐CO2 GHG emissions were reduced by 51%−71%. In contrast, we did not observe a significant biochar effect on CO2 and NH3 emissions. Previous data already showed that it is possible to sanitize human fecal material when using this composting method. Our results suggest that thermophilic composting with biochar addition is a safe and cost‐effective waste management practice for producing a nutrient‐rich fertilizer from human excreta, while reducing GHG emissions at the same time.
Anoikis‐related signature in liver hepatocellular carcinoma defines the YBX1/SPP1 axis by machine learning strategies and valid experiments
Authors: Ma Ying , She Xingguo , Zhao Jie , Liu Shu , Li Cai , Wang Qiang 
Published: April 2023

AbstractBackgroundLiver hepatocellular carcinoma (LIHC) remains a malignant malignancy with a low cure rate. Anoikis is a newly recognized cancer hallmark. However, an Anoikis‐related model has not been clarified in LIHC.MethodsThe Anoikis‐related score in the present study was created using Survival Random Forest and least absolute shrinkage and selection operator (LASSO) machine learning algorithms. Anoikis‐related scores with respect to mutation analysis, immunological analysis, function annotation, and medication prediction were all thoroughly investigated.ResultsThe Anoikis‐related score accurately predicted the patients' immunological activity, altered genes, and medication sensitivity. SPP1 immunological analysis, function annotation, medication prediction, and immunotherapy prediction were systematically investigated. SPP1 may effectively predict the outcomes of immunotherapy. SPP1 was revealed to be a mediator of LIHC cell proliferation and migration. A putative axis in LIHC was YBX1/SPP1.ConclusionsClinical care and the treatment plan for patients with LIHC were anticipated to benefit significantly from the established Anoikis‐related score.
Talcott Parsons on building personality system theory via psychoanalysis
Authors: Treviño A. Javier 
Published: April 2023

AbstractThis article examines Talcott Parsons's efforts at building the theory of personality system as a special case of his general theory of action and places those efforts in historical context. I demonstrate how, during the middle decades of the twentieth century, Parsons employed elements of classic Freudian thought to advance a new appreciation of the personality system and its relations to other action systems. I begin with an overview of the reception of psychoanalysis at the Boston Psychoanalytic Society and Institute, the Massachusetts General Hospital, and the Harvard Department of Social Relations, showing how Parsons's thinking on the personality system cannot be understood apart from his association with these three institutions. I then turn to how Parsons endeavored to integrate his particular brand of sociology with his own interpretation of Freud's writings to explain how the personality system functions and develops. I conclude by showing that while Parsons's involvements with psychoanalysis became more intermittent after the mid‐1950s, to the end of his life he remained steadfast in his enthusiasm for Freud's theory of personality. In short, Parsons always believed that for sociological theory to progress, it needed to engage with psychoanalysis.
Reflections on the use of patient records: Privacy, ethics, and reparations in the history of psychiatry
Authors: Sadowsky Jonathan , Smith Kylie 
Published: April 2023

AbstractOne of the most common questions we get asked as historians of psychiatry is “do you have access to patient records?” Why are people so fascinated with the psychiatric patient record? Do people assume they are or should be available? Does access to the patient record actually tell us anything new about the history of psychiatry? And if we did have them, what can, or should we do with them? In the push to both decolonize and personalize the history of psychiatry, as well as make some kind of account or reparation for past mistakes, how can we proceed in an ethical manner that respects the privacy of people in the past who never imagined their intensely personal psychiatric encounter as subject for future historians? In this paper, we want to think through some of the issues that we deal with as white historians of psychiatry especially at the intersection of privacy, ethics, and racism. We present our thoughts as a conversation, structured around questions we have posed for ourselves, and building on discussions we have had together over the past few years. We hope that they act as a catalyst for further discussion in the field.
[EMIM]AlCl4‐ionic liquid catalyzed mechanochemically assisted synthesis of 3,4‐dihydropyrimidin‐2‐(1H)‐one and thione derivatives
Authors: Popatkar Bhushan B. , Sasane Nitin A. , Meshram Gangadhar A. 
Published: April 2023

Abstract[EMIM]AlCl4 (1‐ethyl‐3‐methylimidazolium tetrachloroaluminate) ionic liquid catalyzed mechanochemically assisted methodology for the Biginelli reaction has been developed successfully. One‐pot, multicomponent reaction between ethyl/methyl acetoacetate, urea/thiourea, and various aromatic/aliphatic and heterocyclic aldehydes in presence of catalytic amount of [EMIM]AlCl4 under grinding conditions in ethanol affords 3,4‐dihydropyrimidin‐2‐(1H)‐one and its thione derivatives. Short reaction time, inclusion of eco‐friendly solvent, moderate to high yield of the product, and operational simplicity are some of the noteworthy features of this protocol. In consequence, the described procedure finds an alternative way to existing methods for the synthesis of the titled compounds.
LSW‐Net: Lightweight Deep Neural Network Based on Small‐World properties for Spine MR Image Segmentation
Authors: He Siyuan , Li Qi , Li Xianda , Zhang Mengchao 
Published: April 2023

BackgroundSegmenting spinal tissues from MR images is important for automatic image analysis. Deep neural network‐based segmentation methods are efficient, yet have high computational costs.PurposeTo design a lightweight model based on small‐world properties (LSW‐Net) to segment spinal MR images, suitable for low‐computing‐power embedded devices.Study TypeRetrospective.PopulationA total of 386 subjects (2948 images) from two independent sources. Dataset I: 214 subjects/779 images, all for disk degeneration screening, 147 had disk degeneration, 52 had herniated disc. Dataset II: 172 subjects/2169 images, 142 patients with vertebral degeneration, 163 patients with disc degeneration. 70% images in each dataset for training, 20% for validation, and 10% for testing.Field Strength/SequenceT1‐ and T2‐weighted turbo spin echo sequences at 3 T.AssessmentSegmentation performance of LSW‐Net was compared with four mainstream (including U‐net and U‐net++) and five lightweight models using five radiologists' manual segmentations (vertebrae, disks, spinal fluid) as reference standard. LSW‐Net was also deployed on NVIDIA Jetson nano to compare the pixels number in segmented vertebrae and disks.Statistical TestsAll models were evaluated with accuracy, precision, Dice similarity coefficient (DSC), and area under the receiver operating characteristic (AUC). Pixel numbers segmented by LSW‐Net on the embedded device were compared with manual segmentation using paired t‐tests, with P < 0.05 indicating significance.ResultsLSW‐Net had 98.5% fewer parameters than U‐net but achieved similar accuracy in both datasets (dataset I: DSC 0.84 vs. 0.87, AUC 0.92 vs. 0.94; dataset II: DSC 0.82 vs. 0.82, AUC 0.88 vs. 0.88). LSW‐Net showed no significant differences in pixel numbers for vertebrae (dataset I: 5893.49 vs. 5752.61, P = 0.21; dataset II: 5073.42 vs. 5137.12, P = 0.56) and disks (dataset I: 1513.07 vs. 1535.69, P = 0.42; dataset II: 1049.74 vs. 1087.88, P = 0.24) segmentation on an embedded device compared to manual segmentation.Data ConclusionProposed LSW‐Net achieves high accuracy with fewer parameters than U‐net and can be deployed on embedded device, facilitating wider application.Evidence Level2.Technical Efficacy1.
Smart Design of Sensor‐Coated Surgical Sutures for Bacterial Infection Monitoring
Authors: Fontana‐Escartín Adrián , Hauadi Karima El , Lanzalaco Sonia , Pérez‐Madrigal Maria M. , Armelin Elaine , Turon Pau , Alemán Carlos 
Published: April 2023

AbstractVirtually, all implantable medical devices are susceptible to infection. As the main healthcare issue concerning implantable devices is the elevated risk of infection, different strategies based on the coating or functionalization of biomedical devices with antiseptic agents or antibiotics are proposed. In this work, an alternative approach is presented, which consists of the functionalization of implantable medical devices with sensors capable of detecting infection at very early stages through continuous monitoring of the bacteria metabolism. This approach, which is implemented in surgical sutures as a representative case of implantable devices susceptible to bacteria colonization, is expected to minimize the risk of worsening the patient's clinical condition. More specifically, non‐absorbable polypropylene/polyethylene (PP/PE) surgical sutures are functionalized with conducting polymers using a combination of low‐pressure oxygen plasma, chemical oxidative polymerization, and anodic polymerization, to detect metabolites coming from bacteria respiration. Functionalized suture yarns are used for real‐time monitoring of bacteria growth, demonstrating the potential of this strategy to fight against infections.