bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of 8-Oxo-1,N6-Ethenoadenine Derivatives on the Activity of RNA Polymerases from SARS-CoV-2 and Escherichia coli
Authors: Petushkov Ivan V. , Aralov Andrey V. , Ivanov Igor A. , Baranov Mikhail S. , Zatsepin Timofey S. , Kulbachinskiy Andrey V. 
Published: January 2025

Abstract
Bacterial and viral RNA polymerases are promising targets for the development of new transcription inhibitors. One of the potential blockers of RNA synthesis is 7,8-dihydro-8-oxo-1,N
6-ethenoadenine (oxo-εA), a synthetic compound that combines two adenine modifications: 8-oxoadenine and 1,N
6-ethenoadenine. In this study, we synthesized oxo-εA triphosphate (oxo-εATP) and showed that it could be incorporated by the RNA-dependent RNA polymerase of SARS-CoV-2 into synthesized RNA opposite template residues A and G in the presence of Mn2+ ions. Escherichia coli RNA polymerase incorporated oxo-εATP opposite A residues in the template DNA strand. The presence of oxo-εA instead of adenine in the template DNA strand completely stopped transcription at the modified nucleotide. At the same time, oxo-εATP did not suppress RNA synthesis by both RNA polymerases in the presence of unmodified nucleotides. Therefore, the oxo-εA modification significantly disrupts nucleotide base pairing during RNA synthesis by RNA polymerases of different classes, and the corresponding nucleotide derivatives cannot be used as potential antiviral or antibacterial transcription inhibitors.
Survey of interactive evolutionary decomposition-based multiobjective optimization methods
Authors: Lárraga Giomara , Miettinen Kaisa 
Published: January 2025

Abstract
Interactive methods support decision-makers in finding the most preferred solution for multiobjective optimization problems, where multiple conflicting objective functions must be optimized simultaneously. These methods let a decision-maker provide preference information iteratively during the solution process to find solutions of interest, allowing them to learn about the trade-offs in the problem and the feasibility of the preferences. Several interactive evolutionary multiobjective optimization methods have been proposed in the literature. In the evolutionary computation community, the so-called decomposition-basedmethods have been increasingly popular because of their good performance in problems with many objective functions. They decompose the multiobjective optimization problem into multiple sub-problems to be solved collaboratively. Various interactive versions of decomposition-based methods have been proposed. However, most of them do not consider the desirable properties of real interactive solution processes, such as avoiding imposing a high cognitive burden on the decision-maker, allowing them to decide when to interact with the method, and supporting them in selecting a final solution. This paper reviews interactive evolutionary decomposition-based multiobjective optimization methods and different methodologies utilized to incorporate interactivity in them. Additionally, desirable properties of interactive decomposition-based multiobjective evolutionary optimization methods are identified, aiming to make them easier to be applied in real-world problems.
An observational study of socioeconomic disparities in psychiatry consultation uptake in Australia, using routinely collected national data from 2015 to 2022
Authors: Meehan Edward , Yeatman Thomas , Shawyer Frances , Rajit Darren , Lakra Vinay , Meadows Graham , Enticott Joanne 
Published: January 2025

Background: The COVID-19 pandemic was associated with increased psychological distress and psychiatric service usage in Australia. Previous research into the first few months of the pandemic found severe inequality in telehealth psychiatry but no change in inequality for psychiatry service usage overall. However, it is unknown how inequality evolved over the remainder of the pandemic, as extended lockdowns continued in major Australian cities. Aims: To understand how socioeconomic inequality in psychiatric consultations changed during the COVID-19 pandemic, using new data from 2020 to 2022. Methods: We analysed routinely collected national Medicare data, provided to us as service counts per Statistical Area 3 (SA3) region by financial year from 2015 to 2016 to 2021 to 2022. We calculated daily rates of psychiatry attendances per 100,000 working age adults within each SA3 region, and we evaluated inequality in the distribution of consults using concentration indices and curves based on the Index of Relative Socio-economic Disadvantage (IRSD). Results: We analysed 7 years of Medicare data from 321 SA3 regions. The national consultation rate increased in 2020 to 2021 from 45.16 to 50.17, and then decreased slightly in 2021 to 22 to 48.65. Inequality as measured by concentration indices rose from 0.169 in 2020 to 2021 to 0.177 in 2021 to 2022. Consultation rates in the most disadvantaged IRSD quintile decreased by 15.9% in 2021 to 2022 compared to smaller decreases of between 1% and 4% in the top 4 quintiles. Conclusion: Our study shows that inequality in mental health service provision increased in the second year of the COVID-19 pandemic to the highest level seen in the 7 years of data we analysed. Individuals within the most disadvantaged IRSD quintile experienced a significant and disproportionate decline in service rates. Close monitoring and more granular data are needed to understand the drivers behind this inequity and its current status, and to inform interventions to improve it.
Factors Associated With FDA-Approved Quit Medication Use Among a Sample of Adult Tobacco Users in a County in Central California
Authors: Manalili Nicola , Merzon Jenelle , Alber Julia , Lent Adrienne 
Published: January 2025

Purpose To examine associations between identified factors to accessing Food and Drug Administration-approved quit medication (FDAQM) and use among a sample of tobacco users. Design Cross-sectional, online survey. Setting County in Central California. Subjects Current adult tobacco users (n = 76). Measures Demographics self-reported likelihood of quitting in the next month, contacting a healthcare provider about quitting, time since last healthcare visit, provider asking about tobacco/nicotine use, provider advice to quit, provider FDAQM prescription and FDAQM use in the past year. Analysis Logistic regression. Results Those with a higher likelihood of quitting had a lower odds of FDAQM use (OR = 0.15, 95% CI = 0.03, 0.73) while those who had contacted a healthcare provider had a higher odds (OR = 15.39, 95% CI = 2.72, 87.05). Conclusion While the sample was limited, this research provides evidence in an understudied tobacco cessation area. More work is needed to understand the generalizability of these results and develop interventions that address these factors.
Baseline Participant Characteristics are Associated With Engagement in a Movement-Based RCT for Chronic Low-Back Pain
Authors: Garnsey Camille L. , Gnall Katherine E. , Emrich Mariel , Park Crystal L. , Starkweather Angela R. , Xu Wanli , Groessl Erik J. , Huedo-Medina Tania B. 
Published: January 2025

Purpose Examine whether baseline participant characteristics predict engagement in a movement-based RCT for chronic low back pain (CLBP). Design Longitudinal study within an RCT. Setting Online. Subjects 138 individuals with CLBP (18-79 years). Intervention Participants were randomized to a 12-week intervention of twice-weekly synchronous online yoga OR stretching/strengthening classes, and received 20-min pre-recorded home videos to complete daily. Measures Baseline questionnaires assessed sociodemographic, psychosocial, and pain factors (100% response rate). Engagement was operationalized as minutes of class attended + minutes of home videos completed. Results Bivariate correlations were computed between baseline variables and engagement. Three multivariate negative binomial generalized linear models (GLMs) were constructed to simultaneously examine predictors of engagement in the domains of sociodemographic, psychosocial, and pain-related factors. Greater engagement was significantly associated with greater baseline age, educational attainment, energy, and emotional well-being, and less emotion regulation difficulties, cannabis use problems, and pain interference (|rs| = .19-.33). In the domain specific GLMs, education (B = .491, P = .017) and cannabis use problems (B = −.048, P = .027) were the only significant predictors in the sociodemographic and psychosocial models, respectively. Neither pain interference nor pain severity were significant in the pain model. Conclusion Factors identified can inform strategies to increase engagement in movement-based CLBP interventions, potentially improving research validity and outcomes. Limitations include lack of racial diversity and not testing how engagement fluctuates throughout the intervention.
Living in Historically Redlined Neighborhoods and the Cognitive Function of Black and White Adults
Authors: Fisk Calley E. , Ailshire Jennifer A. , Walsemann Katrina M. 
Published: January 2025

Objectives We determined if living in historically redlined neighborhoods was associated with level and change in cognitive functioning and if this association differed for Black and White older adults. Methods We linked the Health and Retirement Study 1998–2018 data to redlining scores from the Historic Redlining Indicator data. Our sample included adults aged 50 years and older (24,230 respondents, 129,618 person-period observations). Using three-level linear mixed models, we estimated the relationship between living in historically redlined neighborhoods on level and change in cognitive functioning for pooled and race-stratified samples. Results Residents of historically redlined “Declining” and “Hazardous” neighborhoods had lower cognitive functioning scores compared to residents of “Best/Desirable” neighborhoods. Among Black adults, living in “Hazardous” neighborhoods was associated with slower declines in cognitive functioning compared to living in “Best/Desirable” neighborhoods. Discussion Historical redlining is associated with older adults’ cognitive functioning, underscoring the importance of sociohistorical context for the neighborhood–cognition relationship.
Pre-alignment of fibroblasts induced by micropatterning and cyclic stretching techniques accelerates wound healing
Authors: Toyohara Ryota , Lan Yanan , Chen Yu , Yoriki Takaya , Ohashi Toshiro 
Published: January 2025

Background Wound healing proceeds through a complex collaborative process. It has been shown that during the intermediate phase of the wound healing process, fibroblasts migrate into wound area and contract to contribute to the closure of the wound area. Moreover, previous studies have shown that fibroblast alignment was observed on the mature stage of wound scar. These studies clearly indicate that fibroblasts play a critical role in wound healing process, however, the whole mechanism of wound healing remains still unclear. Objective Fibroblasts are pre-aligned to evaluate the effect of cell alignment on cell migration rate. Methods The cell alignment was accomplished by PDMS microstamping with fibronectin and application of cyclic stretching. Wound was created by physical scratching and then the wound closure rate was measured. Results The pre-aligned cells perpendicular to the direction of scratched wound exhibited significantly higher migration rate, compared to non-aligned control cells. Moreover, pre-aligned cells with thick actin filaments by cyclic stretching migrated faster than those with less development of actin filament structures by microstamping. Conclusion The wound closure can be accelerated by the adequate alignment of fibroblasts as well as the development of actin filament structures.
Online interest in ADHD predicts ADHD medication prescriptions in Australia from 2004 to 2023: A time-series analysis revealing COVID-19-related acceleration
Authors: Sy-Cherng Woon Luke , Smith David , Alllison Stephen , Looi Jeffrey CL , Bastiampillai Tarun 
Published: January 2025

Objective Attention-deficit hyperactivity disorder (ADHD) medication prescriptions in Australia have grown sharply in recent years. We examined the association between online interest in ADHD and prescriptions. Methods Monthly Pharmaceutical Benefits Scheme (PBS) and Repatriation PBS (RPBS) Item Reports of ADHD prescriptions and Australian ADHD-related Google Trends (GT) data (2004–2023) were sourced. We modelled the lagged effect of GT on ADHD medication prescriptions, using an autoregressive moving average model with autoregressive conditional heteroskedasticity, adjusting for COVID-19 lockdown effects. Results were compared to a model of GT for pain-related searches and PBS/RPBS opioid prescriptions, and counterfactual alternatives: (1) ADHD-related GT and opioid prescriptions and (2) pain-related GT and ADHD prescriptions. We descriptively analysed additional ADHD-related online news data. Results Annual prescriptions doubled from 1,424,904 in 2020 to 3,112,072 in 2023. ADHD medication prescriptions and ADHD-related GT considerably increased since the COVID-19 pandemic. GT had a statistically significant positive lagged association with ADHD prescriptions. Comparator models did not show statistically significant associations between GT and prescriptions. Online news data supported recently increased public interest in ADHD. Conclusions ADHD-related online interest predicts increased ADHD prescriptions, which was accentuated during the pandemic. Studies are needed to evaluate causal pathways, health information quality and sociodemographic determinants.
Modified superior capsule reconstruction using the peroneus longus for irreparable massive rotator-cuff tears: A cadaveric study
Authors: Wang Kehao , Ning Rende , Fang Run , Chen Guang , Li Hongyan , Peng Cheng 
Published: January 2025

Background:  Irreparable massive rotator cuff tears (IMRCTs) present substantial treatment challenges, highlighting the necessity of making effective treatments available. Objective:  To evaluate the biomechanical characteristics of a modified procedure of superior capsule reconstruction (mSCR) employing the autologous peroneus longus tendon for the treatment of irreparable massive rotator-cuff tears (IMRCTs), encompassing the entire supraspinatus tendon and 50% of the infraspinatus tendon. Methods:  Seven cadaveric specimens were tested at 0°, 30°, and 60° glenohumeral abduction under the following three conditions: (1) intact, (2) IMRCT, and (3) mSCR using the autologous peroneus longus tendon. Humeral rotational range of motion (ROM), superior translation of the humeral head, and subacromial contact pressure were measured. Repeated-measures ANOVA was followed by Tukey's post hoc test to perform statistical analyses. Results:  At all the abduction angles, superior translation of the humeral head and subacromial contact pressure were higher in the IMRCT group than in the intact group but were significantly lower in the mSCR group than in the IMRCT group. All these differences were statistically significant ( P < 0.05). Conclusion:  The mSCR procedure can reduce the superior translation of the humeral head and subacromial contact pressure without limiting humeral ROM in IMRCTs. Utilizing mSCR with the peroneus longus tendon may serve as a therapeutic approach for IMRCTs.
Task-oriented robotic rehabilitation for back mobility and functioning in a post-intensive care unit obese patient: A case report
Authors: Lippi Lorenzo , de Sire Alessandro , Pizzorno Marco , Turco Alessio , Ariatti Sarah , Curci Claudio , Ammendolia Antonio , Invernizzi Marco 
Published: January 2025

Background Intensive care unit (ICU) acquired weakness is a detrimental condition characterized by muscle weakness, difficulty in weaning from mechanical ventilation, impaired mobility, and functional limitations, severely affecting overall quality of life. Obese patients face additional challenges due to obesity-related factors that exacerbate the negative effects of immobilization. Rehabilitation interventions have emerged as a crucial component of post-ICU care, but the rehabilitation management of obese patients remains challenging. Objective to present the impact of implementing Walker View 3.0 SCX technology in post-intensive care unit rehabilitation of obese patient. Methods A 69-year-old Caucasian man with a BMI of 44.8 kg/m2 was referred to the Cardiopulmonary Rehabilitation Unit at Alessandria Hospital, Italy, following an ICU admission for pneumonia. After a comprehensive multidisciplinary evaluation, the patient underwent an intensive rehabilitation program including physical exercises and a personalized dietary plan. A task-oriented robotic rehabilitation was added, utilizing the Walker View 3.0 SCX, for 30 min/day, 5 days/week. The robotic rehabilitation program focused on sit-to-stand mobility with weight support initially and progressed to a weight-supported robotic treadmill. Results The patient showed clear improvements in physical function, muscle strength, and independence in activity of daily living (Barthel Index improved from 15 to 70, De Morton Mobility Index improved from 8 to 39, Medical Research Council Strength improved from 17 to 40, Functional Ambulation Classification score improved from 0 to 3, Handgrip Strength Test improved from 8.8 kg to 39.4 kg). Managed by a single physiotherapist, this approach showed positive results in enhancing functional outcomes, with potential benefits in reducing operator time and assistance costs. Conclusions Integrating task-oriented robotic rehabilitation with Walker View 3.0 SCX showed promising outcomes for obese patients post-ICU. Personalized interventions with weight-bearing capabilities and real-time feedback optimized post-ICU care, enhancing functional outcomes, and potentially reducing operator time and assistance costs. Further research with larger samples is needed to validate the broader applicability and cost-effectiveness of robotic rehabilitation technologies in obese patients with ICU-acquired weakness.
Influence of Social Media in Multidisciplinary Cleft Care in Indonesia
Authors: Bangun Kristaninta , Tania Vika , Kreshanti Prasetyanugraheni , Halim Jessica 
Published: January 2025

Social media has played a pivotal role in relaying healthcare-related information, especially in efforts to improve cleft management. Cleft management involves a multidisciplinary team throughout the years of comprehensive intervention, from birth to adulthood. To investigate the behaviors of parents and patients with clefts regarding social media use in improving cleft-related outcomes, knowledge, and awareness. This questionnaire-based descriptive study was conducted online and involved both closed- and short-ended questions. Parents and patients with cleft lip and palate provided consent to participate in the study. Patient demographics, history, and timing of cleft treatment, barriers to care, and social media use were explored. Fifty-six participants were enrolled in this study. The mean ages of the mothers and fathers of children with cleft were 34 (range, 24-57) and 36 (range, 26-59) years, respectively, and more than one-half were university graduates. WhatsApp, Instagram, and YouTube were used by 100%, 89%, and 89% of parents, respectively, 82% of whom were part of a cleft community group. Seventy-two percent underwent labioplasty, and 75% underwent palatoplasty at the ideal time. Parents exhibited low perceived barriers to care, with 33% and 37% reporting limitations on knowledge and accommodation, respectively. Social media is the key to bridging the gap between the large number of cases and facility limitations and specialized human resources. Cleft centers should integrate combined platforms ( WhatsApp, YouTube, and Instagram) for marketing and education purposes. Social media and community groups facilitate sharing, engagement, and empowerment of patients and caregivers to improve cleft-related outcomes.
Coronal Plane Alignment of the Medial Column in Isolated Hallux Valgus, Isolated Flatfoot, and Combined Hallux Valgus-Flatfoot
Authors: Lalevee Matthieu , Beaudet Philippe , Saffarini Mo , Agu Chinyelum , Van Rooij Floris , Barbachan Mansur Nacime Salomao , Carvalho Kepler , Dibbern Kevin , de Cesar Netto Cesar 
Published: January 2025

Background: To provide improved treatment for hallux valgus (HV), we sought to understand more about the pathophysiologic connection between flatfoot deformity and HV by comparing coronal plane alignment of the medial column of the foot for patients with isolated HV, isolated flatfoot, and combined HV-flatfoot vs controls. Methods: This study retrospectively assessed a consecutive series of 33 patients with combined symptomatic and radiographic HV and flatfoot, 33 isolated symptomatic HV, 33 isolated symptomatic flatfoot, and 33 controls. The medial column alignment was assessed in the coronal plane using 3-dimensional weightbearing computed tomography (WBCT); rotation was measured for the navicular, medial cuneiform, and first metatarsal (M1). The position of the first naviculocuneiform (NC) and tarsometatarsal (TMT) joints were determined. Results: M1 intrinsic pronation was significantly greater in patients with combined HV-flatfoot (-12.0 ± 7.0 degrees; P < .001), isolated HV (−12.1 ± 6.6 degrees; P < .001), and isolated flatfoot (–11.8 ± 8.5 degrees; P < .001), compared with control patients (−19.4 ± 6.7 degrees). TMT was significantly more pronated in patients with combined HV-flatfoot (30.9 ± 6.2 degrees) compared with isolated flatfoot (25.3 ± 9.3 degrees; P = .007), and control (25.9 ± 5.2 degrees; P = .005), as it was in patients with isolated HV (33.2 ± 8.2 degrees) compared with isolated flatfoot ( P < .001), and control ( P < .001). NC was significantly more supinated in patients with combined HV-flatfoot (−23.7 ± 3.9 degrees) compared to isolated flatfoot (−18.0 ± 9.8 degrees; P = .001), and control (−18.0 ± 4.5 degrees; P < .001), as it was for patients with isolated HV (−24.8 ± 7.1 degrees) compared with isolated flatfoot ( P = .003), and control ( P < .001). Conclusion: In our study, we found that patients with isolated HV, isolated flatfoot, or combined HV-flatfoot presented a similar increase in M1 intrinsic pronation of approximately 7.5 degrees, compared with controls. Moreover, patients with isolated HV or combined HV-flatfoot had greater TMT pronation and NC supination, compared with patients with isolated flatfoot and controls.