bluuebunny/crossref_metadata_2025_split huggingface dataset:
Small telescopes being effective: MAGIC or not?
Authors: Afanasiev Victor L , Malygin Eugene A , Shablovinskaya Elena S , Uklein Roman I , Amirkhanyan Vladimir R , Perepelitsyn Alexander E , Afanasieva Irina V 
Published: September 2023

Abstract
The paper describes the MAGIC multimode focal reducer (Monitoring of Active Galaxies by Investigation of their Cores), commissioned on the 1-m Zeiss-1000 telescope of the Special Astrophysical Observatory of the Russian Academy of Sciences in 2020 September. Three observational modes are currently realized: photometry, polarimetry, and long-slit spectroscopy. Reducing the focal length makes it possible to obtain a sufficiently large field of view for photometry and a large slit height for spectroscopy of ∼12′ , as well as a large field of view for polarimetry with a quadrupole Wollaston prism of ∼6${_{.}^{\prime}}$4. This feature makes the complex study of extended nebulae and galaxies efficient. The MAGIC capabilities are presented in examples of observations of various astronomical objects. The spectral mode in the range of 4000–7200 ÅÅ provides the spectral resolution R ∼ 1000; for a starlike target up to 14 mag in medium-band filters with a seeing of 1″ for 20 min of total exposure, the photometry accuracy is better than 0.01 mag and the polarization accuracy is better than 0.6 per cent. Especially for the new focal reducer, an offset guide and a position angle rotation system were implemented. The results of the modernization of the baffle system in the optical scheme of the telescope for the suppression of scattered light are also described.
Metabolic disturbance and transcriptomic changes induced by methyl triclosan in human hepatocyte L02 cells
Authors: An Jing , Yi Yuting , Jiang Jingjing , Yao Weiwei , Ren Guofa , Shang Yu 
Published: September 2023

Abstract
Purpose: Methyl triclosan (MTCS) is one of the biomethylated by-products of triclosan (TCS). With the increasing use of TCS, the adverse effects of MTCS have attracted extensive attention in recent years. The purpose of this study was to investigate the cytotoxicity of MTCS and to explore the underlining mechanism using human hepatocyte L02 cells as in vitro model. Results: The cytotoxicity results revealed that MTCS could inhibit cell viability, disturb the ratio of reduced glutathione (GSH) and oxidized glutathione (GSSG), and reduce the mitochondrial membrane potential (MMP) in a dose-dependent manner. In addition, MTCS exposure significantly promoted the cellular metabolic process, including enhanced conversion of glucose to lactic acid, and elevated content of intracellular triglyceride (TG) and total cholesterol (TC). RNA-sequencing and bioinformatics analysis indicated disorder of glucose and lipid metabolism was significantly induced after MTCS exposure. Protein-protein interaction network analysis and node identification suggested that Serine hydroxy methyltransferase 2 (SHMT2), Methylenetetrahydrofolate dehydrogenase 2 (MTHFD2), Asparagine synthetase (ASNS) and Phosphoglycerate dehydrogenase (PHGDH) are potential molecular markers of metabolism imbalance induced by MTCS. Conclusion: These results demonstrated that oxidative stress and metabolism dysregulation might be involved in the cytotoxicity of MTCS in L02 cells.
Real-World Utilization of an Intrauterine, Vacuum-Induced, Hemorrhage-Control Device
Authors: Goffman Dena , Rood Kara M. , Bianco Angela , Biggio Joseph R. , Dietz Paul , Drake Kelly , Heilman Erica , Hopkins Maeve , De Four Jones Monique , Katz Tyler , Martin Courtney , Prasad Mona , Smid Marcela C. , Wine Kathryn D. , Ryan Robert , Yong Candice , Carney Patricia I. , Simhan Hyagriv N. 
Published: September 2023

OBJECTIVE:
To assess the real-world effectiveness and safety of a U.S. Food and Drug Administration (FDA)–cleared intrauterine vacuum-induced-hemorrhage control device for postpartum hemorrhage (PPH) management.

METHODS:
Sixteen centers in the United States participated in this observational, postmarket registry medical record review (October 2020 through March 2022). The primary effectiveness outcome was treatment success, defined as bleeding control after insertion with no treatment escalation or bleeding recurrence. Additional outcomes included blood loss, time to device insertion, indwelling time, bleeding recurrence, and time to bleeding control. Treatment success and severe maternal morbidity measures (transfusion of 4 or more units of red blood cell, intensive care unit admission, and hysterectomy) were evaluated by blood loss before insertion. To assess safety, serious adverse events (SAEs) and adverse device effects were collected. All outcomes were summarized by mode of delivery; treatment success was summarized by bleeding cause (all causes, any atony, isolated atony, nonatony).

RESULTS:
In total, 800 individuals (530 vaginal births, 270 cesarean births) were treated with the device; 94.3% had uterine atony (alone or in combination with other causes). Median total blood loss at device insertion was 1,050 mL in vaginal births and 1,600 mL in cesarean births. Across all bleeding causes, the treatment success rate was 92.5% for vaginal births and was 83.7% for cesarean births (95.8% [n=307] and 88.2% [n=220], respectively, in isolated atony). Median indwelling time was 3.1 hours and 4.6 hours, respectively. In vaginal births, 14 SAEs were reported among 13 individuals (2.5%). In cesarean births, 22 SAEs were reported among 21 individuals (7.8%). Three (0.4%) SAEs were deemed possibly related to the device or procedure. No uterine perforations or deaths were reported.

CONCLUSION:
For both vaginal and cesarean births in real-world settings, rapid and effective bleeding control was achieved with an FDA-cleared intrauterine vacuum-induced hemorrhage-control device. The safety profile was consistent with that observed in the registrational trial (NCT02883673), and SAEs or adverse device effects were of the nature and severity expected in the setting of PPH. This device is an important new tool for managing a life-threatening condition, and timely utilization may help to improve obstetric hemorrhage outcomes.

CLINICAL TRIAL REGISTRATION:

ClinicalTrials.gov, NCT04995887.
Society of Critical Care Medicine Clinical Practice Guidelines for Rapid Sequence Intubation in the Critically Ill Adult Patient
Authors: Acquisto Nicole M. , Mosier Jarrod M. , Bittner Edward A. , Patanwala Asad E. , Hirsch Karen G. , Hargwood Pamela , Oropello John M. , Bodkin Ryan P. , Groth Christine M. , Kaucher Kevin A. , Slampak-Cindric Angela A. , Manno Edward M. , Mayer Stephen A. , Peterson Lars-Kristofer N. , Fulmer Jeremy , Galton Christopher , Bleck Thomas P. , Chase Karin , Heffner Alan C. , Gunnerson Kyle J. , Boling Bryan , Murray Michael J. 
Published: September 2023

RATIONALE:
Controversies and practice variations exist related to the pharmacologic and nonpharmacologic management of the airway during rapid sequence intubation (RSI).

OBJECTIVES:
To develop evidence-based recommendations on pharmacologic and nonpharmacologic topics related to RSI.

DESIGN:
A guideline panel of 20 Society of Critical Care Medicine members with experience with RSI and emergency airway management met virtually at least monthly from the panel’s inception in 2018 through 2020 and face-to-face at the 2020 Critical Care Congress. The guideline panel included pharmacists, physicians, a nurse practitioner, and a respiratory therapist with experience in emergency medicine, critical care medicine, anesthesiology, and prehospital medicine; consultation with a methodologist and librarian was available. A formal conflict of interest policy was followed and enforced throughout the guidelines-development process.

METHODS:
Panelists created Population, Intervention, Comparison, and Outcome (PICO) questions and voted to select the most clinically relevant questions for inclusion in the guideline. Each question was assigned to a pair of panelists, who refined the PICO wording and reviewed the best available evidence using predetermined search terms. The Grading of Recommendations, Assessment, Development, and Evaluations (GRADE) framework was used throughout and recommendations of “strong” or “conditional” were made for each PICO question based on quality of evidence and panel consensus. Recommendations were provided when evidence was actionable; suggestions, when evidence was equivocal; and best practice statements, when the benefits of the intervention outweighed the risks, but direct evidence to support the intervention did not exist.

RESULTS:
From the original 35 proposed PICO questions, 10 were selected. The RSI guideline panel issued one recommendation (strong, low-quality evidence), seven suggestions (all conditional recommendations with moderate-, low-, or very low-quality evidence), and two best practice statements. The panel made two suggestions for a single PICO question and did not make any suggestions for one PICO question due to lack of evidence.

CONCLUSIONS:
Using GRADE principles, the interdisciplinary panel found substantial agreement with respect to the evidence supporting recommendations for RSI. The panel also identified literature gaps that might be addressed by future research.
Factors Associated with Treatment Outcome Satisfaction Six Months after Upper Blepharoplasty: A Large Cohort Study
Authors: Luong Kim Phi , Vissers Lieke C. M. , Domela Nieuwenhuis Ileen , Hazenkamp Lisa S. , Hummelink Stefan , Slijper Harm P. , Ulrich Dietmar J. O. 
Published: September 2023

Background:
Upper blepharoplasty is the most popular facial cosmetic surgery. Although there are a variety of reasons to undergo this procedure, all patients expect an optimal cosmetic result. However, little is known about the factors that influence satisfaction with treatment outcome.

Objectives:
We assessed to what extent patient characteristics, clinician-rated and postsurgical outcome measures, and patient-reported satisfaction with facial appearance and quality-of-life are associated with patient-reported satisfaction with treatment outcome after a primary upper blepharoplasty.

Methods:
This study was performed in 583 patients with an upper blepharoplasty between 2016 and 2021. The primary outcome was satisfaction with treatment outcome 6 months postoperatively using the FACE-Q. Determinants were baseline patient characteristics (demographics), preoperative and postoperative clinician-rated and surgical outcome measures, and preoperative and postoperative FACE-Q appearance and quality-of-life scales. Hierarchical linear regression analysis was used to determine how much of the variance in satisfaction with outcome could be explained by these groups of determinants.

Results:
A total of 63% of the variance could be explained by the five groups of determinants of which 8% was explained by the baseline patient characteristics and clinician-rated and patient-reported outcomes together, another 8% by the postoperative clinician-rated outcomes, and the remaining 47% by the postoperative patient-reported outcomes.

Conclusions:
Patient characteristics, clinician-rated outcome measures, and baseline FACE-Q appearance and quality-of-life scores were of limited value in explaining satisfaction with treatment outcome. However, the postoperative FACE-Q appearance scale and the decision to undergo a blepharoplasty were strongly associated with satisfaction with treatment outcome.
In vivo CRISPR screen identifies LTN1 as a novel tumor suppressor ubiquitinating insulin–like growth factor 2 mRNA–binding protein 1 in hepatocellular carcinoma
Authors: Peng Rui , Cao Jun , Zhang Chi , Zhou Jie , Su Bing-Bing , Tu Dao-Yuan , Jiang Guo-Qing , Jin Sheng-Jie , Xu Ya-Ping , Bai Dou-Sheng 
Published: September 2023

Background and Aims:
Hepatocellular carcinoma (HCC) is a frequent and aggressive kind of cancer. Although E3 ligases play important roles in HCC development, several E3 ligases remain unknown.

Approach and Results:
Through in vivo CRISPR knockout (KO) screens targeting related E3 ligase genes in HCC nude mice models, we discovered LTN1 as a novel tumor suppressor in HCC. Co-IP paired with 2D-LC-MS/MS and subsequent western blotting in HCC cells were used to identify the interactome of LTN1. Compared to matched normal tissues, the expression of LTN1 was decreased in human HCC tissues (ANT) (157/209). Clinically, patients with HCC who expressed low levels of LTN1 had a poor prognosis. Forced expression of LTN1 decreased cell growth in vitro and in vivo, whereas knockdown of LTN1 increased cell growth. Mechanistically, elevated LTN1 expression inhibited HCC cell growth by ubiquitinating and destabilizing the IGF2BP1 protein, which inhibited the c-Myc and IGF-1R signaling pathways. There was a negative correlation between the LTN1 protein expression and the IGF2BP1 protein expression in HCC tissues (R2=0.2799, P=0.0165).

Conclusions:
LTN1 may be a crucial tumor suppressor for determining the prognosis and a possible therapeutic target since it inhibits the proliferation of HCC cells by ubiquitinating IGF2BP1.
Knockdown of CXCL1 improves ACLF by reducing neutrophil recruitment to attenuate ROS production and hepatocyte apoptosis
Authors: Tang Shima , Zhang Junlei , Zhang Lingjian , Zhao Yalei , Xiao Lanlan , Zhang Fen , Li Qian , Yang Ya , Liu Qiuhong , Xu Jinxian , Li Lanjuan 
Published: September 2023

Background:
Acute-on-chronic liver failure (ACLF) is an acute decompensated syndrome based on chronic liver disease, while neutrophil recruitment is the most critical early step. C-X-C motif chemokine ligand 1 (CXCL1), a cytokine that recruits neutrophils, was significantly upregulated in both ACLF mice and patients with ACLF. This present study aims to explore the role of CXCL1 in the pathogenesis of ACLF.

Methods:
We established an ACLF mouse model induced by carbon tetrachloride, lipopolysaccharide, and D-galactosamine, and used adeno-associated virus to achieve overexpression and knockdown of Cxcl1. We employed mass cytometry, flow cytometry, multiplex cytokine and chemokine analysis, Western blot, and reactive oxygen species (ROS) detection in mice blood and liver. ACLF patients (n = 10) and healthy controls (n = 5) were included, and their liver samples were stained using multiplex immunohistochemistry techniques.

Results:
CXCL1 was significantly elevated in both ACLF mice and patients. CXCL1 recruits neutrophils by binding to the C-X-C motif chemokine receptor 2 on the surface of neutrophils, affects ACLF prognosis by generating ROS and mitochondrial depolarization and modulating caspase3-related apoptotic pathways. We found that the knockdown of CXCL1 attenuated the infiltration of neutrophils in the mouse liver, reduced the expression of inflammatory cytokines, and also significantly downregulated ROS production and caspase3-related hepatocyte apoptosis, thereby ameliorating the liver injury of ACLF.

Conclusions:
CXCL1 is a core player in the mobilization of neutrophils in ACLF, and the knockdown of Cxcl1 improves neutrophil infiltration, reduces ROS levels, and reduces hepatocyte apoptosis, thereby attenuating inflammation and liver injury in ACLF. Our results revealed a previously unknown link between CXCL1-induced neutrophil recruitment and ACLF, providing evidencing for potential therapies targeting ACLF.
Ten-year longitudinal morphological changes in dome-shaped maculas in highly myopic eyes
Authors: Hsu Cherng-Ru , Igarashi-Yokoi Tae , Liang I-Chia , Ohno-Matsui Kyoko 
Published: September 2023

Abstract

Purpose:
To determine the longitudinal changes in the morphologic features of dome-shaped macula (DSMs) in highly myopic eyes.

Methods:
Patients with a DSM and high myopia (spherical equivalent <-8 diopters [D] or axial length ≥26.5 mm) were retrospectively studied. The medical records, optical coherence tomographic (OCT) images, and ultra-widefield OCT images were analyzed.

Results:
A total of 113 eyes of 82 patients were studied with a mean follow-up of 122.32 ± 6.36 months. During the follow-up, the mean dome height was significantly increased from 181.51 ± 105.55 to 209.85 ± 130.84 μm (P<0.001). There was also a significant increase in the axial length (30.83 ± 1.82 to 31.16 ± 1.86 mm; P<0.001). Subgroup analyses showed that the dome height increased more than 50 μm in 78 (69%) eyes, decreased in 23 (20%) eyes, and was stable in 12 (11%) eyes. The change in the axial lengths was significantly greater in the increased dome height group than in the decreased and stable dome height groups (P=0.042). Multivariable analysis showed that the greater axial length change (OR, 8.73; P=0.017) and horizontal type DSM (OR, 4.14; P=0.026) were significantly associated with the increase in the dome height.

Conclusion:
The direction of change in the DSM height varies and 69% of the eyes had an increase in height while 20% of the eyes had a decrease in height. The variations in the dome height may result from the difference between the deepening of the peri-dome scleral excavation and the changes of the axial length.
Working Status of First-Time Postpartum Mothers and Telomere Length—A 1-Year Prospective Study
Authors: Houminer-Klepar Nourit , Bord Shiran , Epel Elissa , Lin Jue , Sultan Linoy , Baron-Epel Orna 
Published: September 2023

Objective
Transitioning to motherhood can create work family conflicts affecting mothers’ health. Although employment is generally associated with longer telomeres, this may diminish during the early years of child-rearing. This study aimed to assess the impact of work reentry on telomere length (TL) among first-time mothers.

Methods
In this 1-year prospective study, a total of 103 first-time postpartum mothers participated from two medical institutions in Northern Israel; they completed validated questionnaires, reported their current working status, and provided dried blood spots measuring TL.

Results
We found that working status significantly predicted change in TL and was negatively correlated with change in TL over time (β = −0.245; 95% confidence interval, −0.169, −0.018; P = 0.016).

Conclusions
Identifying ideal timing of work reentry is recommended for first-time postpartum mother’s optimal health and TL.
Epidemiology of Work-Related Traumatic Brain Injury and COVID-19 Pandemic Lockdown Consequences: Experience in a Reference Center in Chile
Authors: Wimmer Del Solar Jonathan , Rojas-Líbano Daniel , Bastías Barra Pablo , Cisternas Vera Constanza , Chávez Martel Paulina , Rozas Vidal Juan Pablo , Rodríguez Ibáñez Pamela , Fontecilla Villalobos Estefanía 
Published: September 2023

Introduction
Work-related traumatic brain injury is a frequent cause of chronic morbidity, mortality, and high treatment costs. Its causes are highly environmentally determined and were affected by COVID-19 pandemic lockdowns.

Objective
We aimed to describe traumatic brain injury (TBI) epidemiology in working population and evaluate its modifications during the COVID-19 pandemic.

Methods
We performed a 2-year retrospective epidemiological analysis of TBI patients hospitalized in a tertiary work-related hospital before and during the COVID-19 pandemic.

Results
In the prepandemic period, TBI patients were predominantly men, with a bimodal age distribution. Crash accidents were the leading work-related traumatic brain injury cause. During COVID-19 pandemic lockdowns, there was a positive correlation between street traffic and TBI rate, presenting increased motor crash accidents as a cause of TBI.

Conclusions
These results are relevant for planning and focalization of resources for TBI prevention.
Effect of Subsensory Vibration on Postural Control of Healthy Elderly and Subjects with Simulated Reduced Plantar Feet Sensation: A Randomized Crossover Controlled Trial
Authors: Aboutorabi Atefeh , Arazpour Mokhtar , Hadadi Mohamad , Veiskarami Masoumeh 
Published: September 2023

Abstract

Introduction
Postural instability is considered a normal result of aging and is caused by some diseases such as neuropathy.

Aim
The purpose of the present study was to analyze and compare the effect of subthreshold vibration that was applied to the plantar surface of feet on balance control of healthy elderly and young subjects with simulated decreased plantar feet sensation.

Methods
Twenty-four subjects (12 elderly persons and 12 young persons with decreased plantar feet sensation) were included in this randomized, double-blinded crossover study. Participants were divided into two intervention groups: 1) orthopedic shoe with vibration mechanism on; and 2) orthopedic shoe with vibration off. Primary outcomes were center of pressure (COP) parameters including mean velocity, phase plane portrait, standard deviation (SD) of amplitude, and SD of velocity. Secondary outcomes were Berg Balance Scale (BBS) score and timed up and go test (TUG). The standing balance was tested with different conditions: eye opened/closed and foam/rigid surface. General linear mixed models tests were used for statistical analysis. The level of statistical significance was set at 0.05 for all analyses.

Discussion
This study showed very large effect sizes (partial η2 > 0.2) with application of vibration as compared with vibration off for COP parameters with greater effects in condition with more baseline fluctuations. There was significant change in BBS test (Cohen d, 0.6; confidence interval [CI], −0.215 to −1.421). The time on TUG test was decreased and approached significance (P = 0.06).

Conclusions
The immediate effect of the study showed that subthreshold vibration can improve static and dynamic balance in healthy elderly people and people with decreased plantar feet sensation. However, long-term studies are needed to establish the clinical value of the subthreshold vibration on balance control.

Clinical Relevance
Subthreshold vibration applied to the feet soles via custom-made shoes can reduce the postural sway in subjects with decreased feet sensation. By conducting more studies with conclusive results in the field of vibration effectiveness in the elderly, we can hope to reduce the rate of falls in the elderly.
Racial Disparities in Utilization of Emergency Medical Services and Related Impact on Poststroke Disability
Authors: Wu Yuqi , Xirasagar Sudha , Nan Zixiao , Heidari Khosrow , Sen Souvik 
Published: September 2023

Background:
Prompt seeking of emergency medical services (EMS) assistance at stroke onset is critical to minimize poststroke disability.

Objective:
The aim was to study how racial differences in EMS decision-relevant factors and EMS use impact stroke care and disability outcomes.

Design:
A prospective observational study.

Participants:
A total of 1168 acute ischemic stroke patients discharged from April 2016 to October 2017 at a safety net hospital were included; 108 patients were surveyed before discharge.

Measures:
(1) Prehospital delay: EMS use, timely hospital arrival; (2) Stroke care: alteplase receipt and inpatient rehab; (3) Outcomes: Functional improvement at discharge (admission minus discharge scores on National Institutes of Health Stroke Scale), 90-day modified Rankin Scale; (4) EMS decision-relevant factors: Stroke symptom knowledge, source of knowledge, unfavorable past EMS/care experiences, and financial barriers to EMS use.

Results:
Despite more Black patients using EMS than Whites/Asians (56% vs. 48%, P=0.003), their timely hospital arrival was 30% less likely. Adjusted for stroke severity, receipt of alteplase, and inpatient rehab were similar, but Black patients fared worse on functional improvement at discharge (among severe strokes, 2.4 National Institutes of Health Stroke Scale points less improvement, P<0.01), and on functional normalcy at 90 days (modified Rankin Scale score 0–1 being 60% less likely across severity categories) (P<0.01). Fewer Black patients knew any stroke symptoms before the stroke (72% vs. 87%, P=0.03), and fewer learned about stroke from providers (P=0.01). Financial barriers and provider mistrust were similar.

Conclusions:
Black patients had less knowledge of stroke symptoms, more care-seeking delay, and poorer outcomes. Including stroke education as a standard of chronic disease care may mitigate stroke outcome disparities.