bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nanostructured Lipid Carrier of Cinacalcet HCl: Formulation, BBD Enabled Optimization, Pharmacokinetic and In-Vitro Cytotoxicity Study
Authors: Nayak Sabita , Sruti Jammula , Patra Chinam Niranjan , Jena Goutam Kumar , Panigrahi Kanhu Charan , Kumar Nandika Khirod 
Published: March 2023

Background:
Cinacalcet hydrochloride (CINH) is a BCS class IV drug. It is mainly used for the treatment of chronic renal disease and parathyroid cancer. It exhibits poor oral bioavailabil-ity of less than 25%.

Objectives:
The main objective is to improve the bioavailability of CINH by formulating the nanostructure lipid carrier (NLC).

Methods:
In this research, glyceryl monostearate (GMS), labrasol, and tween 20 were the main ex-cipients selected for the formulation of NLC. Hot high-speed homogenization and ultra-sonication method was used for the NLC formulation of CINH. The characterization of the NLCs was done as per standard procedures. Optimization of the formulated NLC was carried out by applying Box-Behnken Design (BBD) with the help of the Design Expert software. The pharmacokinetic study was conducted to determine the improvement in the bioavailability of the CINH. The cytotoxicity study was performed by using the MTT assay method to know the cell viability.

Results:
The optimized NLC formulation exhibited high drug content with a particle size of less than 200nm. A pharmacokinetic study showed 4 fold increase in oral bioavailability for the opti-mized NLC in comparison to the aqueous suspension of CINH. Minimum viability was determined as 94%, which indicates the safety of the incubated formulations.

Conclusion:
NLC formulation has the potential to improve oral bioavailability with high drug load-ing and cell viability for CINH.
An Update on the Anti-diabetic Functions of Genistein: A Soybean (Glycine max (L.) Merr.) Isoflavone
Authors: Sharifinejad Niusha , Hooshyar Matin , Ramezankhah Mohammad , Shamsehkohan Amirreza , Saie Rezvan , Sahebjam Mina , Aleebrahim-Dehkordi Elahe , Orandi Shirin , Faraji Ali , Deravi Niloofar 
Published: March 2023

Abstract:Type 2 diabetes mellitus (T2DM) is a developing worldwide issue. Traditionally, different plants have been used throughout history to lower blood glucose and improve the impact of diabetes. Also, today, many natural products have been introduced to lower blood glucose in T2DM patients. The beneficial effects of genistein, the most essential and abundant isoflavone of soybean (Glycine max (L.) Merr.), on blood glucose and other metabolic indicators, as well as diabetesrelated complications, have been widely investigated. In the current narrative review, through a thorough search from "2013-2020” in “PubMed", "Scopus", “ResearchGate”, “Google Scholar”, and "Web of Science" databases, we have retrieved, reviewed, and summarized all clinical trials, as well as in vitro and in vivo studies on the anti-diabetic potential of genistein.
Factors that affect feeding infants with HIV mothers
Authors: Kasim Nurhayati , Kurniati Nurul 
Published: March 2023

HIV is a virus that damages the immune system and weakens the body's ability to fight infections and diseases, HIV mothers have a very important role in baby growth and development, one way to improve the degree of health of the baby is by breastfeeding the babies. Breastfeeding a baby with HIV mothers can be done if the mother has received ARV therapy, but until now feeding by HIV mothers is still controversial. Purpose: to examine the factors that affect feeding babies with HIV mothers. Method: the method used is scoping review. Scoping reviews are used to surface literature and to obtain information about research activities related to the topic under study and identify problems in the research area to be studied, create a framework by identifying research questions through P EO, and identify relevant learning through Google Scholar, Pubmed, and Science Direct, selecting study articles with the Prisma Flow Chart, mapping charting data and drawing the flow of article search, compiling, summarizing and reporting results and discussions using qualitative methods,,,
A Rare Case: Adenocarcinoma Bronchogenic Dextra Std IVB on Gefitinib (15 months) accompanied by Decreased Visual Acuity, Bilateral Sensorineural Deafness and Psychiatric Disorders with No Radiological Evidence of Brain Metastasis
Authors: Ensang Timuda Caesar , Dwi Pratiwi Suryanti , Rahmawati Dessika , Yudhantara Dearisa , Erawati Dini , Indrasworo Dyah , Prayitnaningsih Seskoati 
Published: March 2023

Background: Leptomeningeal disease occurs in 3-5% of patients with lung cancer, mainly adenocarcinoma subtype. Adenocarcinoma is the most common histological finding in Asian women.
Case: A 51-year-old woman with right-sided bronchogenic adenocarcinoma T4N3M1c Std IVB mutation(+) developed decreased vision, severe bilateral sensorineural deafness and psychiatric disorders after receiving Gefitinib 15 months. There was no evidence of brain metastasis from brain MRI. From evaluation of chest CT-scan, we found the disease was progressive and no Mutation Detected from ctDNA, so Gefitinib was discontinued.
Conclusion: We found some difficulties in evaluating side effects of therapy and disease progression due to patient's condition in the form of decreased total vision, severe sensorineural deafness, and psychiatric disorders. However, because no radiological evidence of brain metastases was found, we suspect this patient suffered from leptomeningeal disease.
Keywords: Lung Cancer, Adenocarcinoma, Gefitinib, Leptomeningeal Disease
Das formas embrionárias às formas complexas do discurso: movimentos linguístico-enunciativos da criança na aquisição da língua materna (From embryonic forms to complex forms of discourse: the child’s linguistic-enunciative operations during ...)
Authors: Silva Carmem Luci da Costa , Diedrich Marlete Sandra 
Published: March 2023

Este artigo objetiva responder à seguinte questão investigativa: como a criança, na aurora de sua vida, instancia, via movimentos linguístico-enunciativos, formas embrionárias e como, em sua história na linguagem, insere formas complexas do discurso, caso das narrativas, nas relações enunciativas com o outro? Para tanto, ancorado na Teoria da Linguagem de Émile Benveniste, o presente estudo investiga fatos de linguagem de uma criança acompanhada em coletas naturalísticas e longitudinais nas seguintes faixas etárias: 2 meses e 12 dias; 7 meses e 29 dias; 3 anos e 8 meses. Os resultados da análise apontam que, na constituição da história de enunciações da criança, os sentidos produzidos, na relação com outros, promovem o deslocamento da criança de formas embrionárias para formas complexas do discurso. Nesse deslocamento, enredam-se aspectos de ordem social e de ordem individual, reveladores da instauração da criança nos dois modos de ser língua: como sistema e como discurso.
Ideologia em O Capital e A Ideologia Alemã
Authors: Monfardini Rodrigo Delpupo 
Published: March 2023

O objetivo do artigo é defender a existência de um conceito de ideologia em O Capital de Marx. A hipótese é que, como ideologia em Marx e Engels é uma forma de conhecimento (ou forma de consciência) socialmente difundida que estabelece uma hierarquia de valores e orienta a ação dos indivíduos, pode-se defender a existência de um conceito de ideologia também na crítica da economia política realizada por Marx. Isso porque, como a realidade social gera um conjunto de necessidades entre as quais estão incluídas as ideias, qualquer conjunto de crenças afirmativo de determinada realidade pode ser considerado uma ideologia.
Deep Q-Learning based resource allocation and load balancing in a mobile edge system serving different types of user requests
Authors: Yıldız Önem , Sokullu Radosveta Ivanova 
Published: March 2023

AbstractWith the expansion of the communicative and perceptual capabilities of mobile devices in recent years, the number of complex and high computational applications has also increased rendering traditional methods of traffic management and resource allocation quite insufficient. Recently, mobile edge computing (MEC) has emerged as a new viable solution to these problems. It can provide additional computing features at the edge of the network and allow alleviation of the resource limit of mobile devices while increasing the performance for critical applications especially in terms of latency. In this work, we addressed the issue of reducing the service delay by choosing the optimal path in the MEC network, which consists of multiple MEC servers that has different capabilities, applying network load balancing where multiple requests need to be handled simultaneously and routing selection based on a deep- Q network (DQN) algorithm. A novel traffic control and resource allocation method is proposed based on deep Q-learning (DQL) which allows reducing the end-to-end delay in cellular networks and in the mobile edge network. Real life traffic scenarios with various types of user requests are considered and a novel DQL resource allocation scheme which adaptively assigns computing and network resources is proposed. The algorithm optimizes traffic distribution between servers reducing the total service time and balancing the use of available resources under varying environmental conditions.
Comparing the Impact of Brand and User-Generated Video Content on Online Shoppers’ Purchasing Intentions
Authors: ISRAFILZADE Khalil , BAGHIROVA Sakina 
Published: March 2023

Abstract
Social media enables users to share their purchase experiences. Nevertheless, video content marketing tactics enable companies to influence the attitudes of online shoppers to increase their purchase intentions. The paper solves the research problem of using video content marketing to differentiate between brand and user-generated videos to increase positive customer purchasing intention in the case of Instagram. It aims to find the differences between brand and user-generated videos, which determine online shoppers’ positive purchase intention toward e-commerce on Instagram. Two online questionnaires were distributed to participants, and comparisons were made between related factors. The findings suggest that content marketing on Instagram is vital in driving consumer attitudes and purchase intentions. Consumers are not driven by a certain content marketing approach if the content is of a certain level of complexity. As a result, user-generated videos have become an essential Instagram strategy; brand videos, on the other hand, are less effective.
Scoping out the Common-Sense Perspective on Meaningful Work: Theory, Data and Implications for Human Resource Management and Development
Authors: TOMMASI Francesco , SARTORI Riccardo , CESCHI Andrea 
Published: March 2023

Abstract

Background/Purpose: Meaningful work is a topic of relevant interest to management and organizational scholars. The study of meaningful work has been heavily characterized by theories from different disciplines, yet the common-sense perspective is often overlooked, i.e., a non-academic perspective of meaningful work. The paper presents a qualitative study on how non-academics define meaningful work.

Methods: Adopting the lens of Aristotelian logic, the paper presents a methodological-theoretical approach to explore how non-academics define human resource management concepts. We asked 194 workers to propose ultimate definitions of the concept of meaningful work. The questions were submitted via a short survey collecting demographics.

Results: The analysis of the collected definitions led to the proposition of an intensive definition of meaningful work according to which meaningful work is a positive experience associated with a sense of competence, the presence of positive relation with others, significance and purpose of work. Yet, there must be good reasons to experience work as meaningful as the environment may contain barriers to the presence of meaningfulness.

Conclusion: Methodologically, the paper advances a novel approach to the study of human resource management and development concepts. Theoretically, the study proposes a novel perspective of meaningful work prioritizing concerns on the common-sense.
Philo of Alexandria and the Epistle to the Hebrews on the Concept of the Spiritualization of the Cult
Authors: Botica Aurelian 
Published: March 2023

AbstractThe Epistle to the Hebrews contains one of the most unique Greek lexicology and syntax of all the New Testament writings. Behind syntax, however, there lies a very profound theological vision on topics such as Christ, Temple, holiness, perseverance and salvation. Studying Hebrews against the background of Graeco-Roman culture, the source that most contemporary scholars mention as being closest to the world of Hebrews in this context is Philo of Alexandria. Not only on philological grounds, but also in matters of methods of interpreting the Old Testament cult and in theology, Hebrews and Philo share a very common background. Analyzing the Epistle to the Hebrews comparatively, we are bound to ask whether or not comparsions such as these are warranted. In the following study we will state the state of the problem and then will examine the two sources that seem to have served as a source of inspiration for the author of Hebrews: the Old Testament and Philo of Alexandria. We will focus exclusively on the issues of the method of allegory and the spiritualization/reinterpretation of Old Testament cultic entities, since both Philo and Hebrews are characterized by these concerns. In essence, we will want to know who or what served as the most plausible source of inspiration for the author of Hebrews in the particular area of the reinterpretation of the Old Testament cult.
Automated Finite Element Solution of Diffusion Models for Image Denoising
Authors: BOUFALA ABDERRAZZAK , KALMOUN EL MOSTAFA 
Published: March 2023

AbstractWe present in this paper a numerical solution of a generalized diffusion-based image denoising model, using the finite element computing platform FEniCS. The generalized model contains as special cases three classical denoising techniques: linear isotropic diffusion, total variation, and Perona-Malik method. The numerical simulation using four classical grayscale images demonstrates the superior performance of the finite element method over the finite difference method in terms of both the denoising quality and the computational work.
On the Construction of Short Addition-Subtraction Chains and their Applications
Authors: Ngom Moussa , Tall Amadou 
Published: March 2023

Abstract
The problem of computing xn
effciently, such that x and n are known to be very interesting, specially when n is very large. In order to find effcient methods to solve this problem, addition chains have been much studied, and generalized to addition-subtraction chains. These various chains have been useful in finding effcient exponentiation algorithms. In this paper, we present a new method to recover all existing exponentiation algorithms. It will be applied to design a new fast exponentiation method.
Some Important Edible Wild Plants of Türkiye and Their Use in Culinary
Authors: Pehlivan Tuba 
Published: March 2023

Although concepts such as global climate crisis and global warming, which are frequently used with the industrial revolution, did not make people very nervous before, countries and scientists have begun to think more about this issue today. Recently, with this climate crisis, another crisis deepened by Covid-19, wars and economic problems has been brought to the agenda: The Global Food Crisis. The possibility that people's economic and ecological conditions cannot reach enough and always the same amount of food is becoming increasingly unsettling. With these conditions, it is foreseen that people will include edible herbs in their natural habitats in their menus, as they did in the countryside from time immemorial. There are different studies on natural edible herbs in different disciplines, but there are very few studies evaluating these herbs from a gastronomic point of view. Studies such as the dissemination of traditional knowledge about natural edible herbs and the preparation of recipes for foods and beverages made with these plants are studies that can also find response in fields such as economy, sociology, tourism, health and agriculture. Carrying out all these studies in combination can also contribute to healty and gastronomy-themed tourism. For this reason, in our study, studies on natural edible herbs in Türkiye were compiled and evaluated in a way to cover ancient times and today and different disciplines. As a result of the evaluation, natural edible plants that came to the fore in previous studies and our study were determined and information about the food parts of these plants, their usage areas and usage patterns were given.
Faktor Yang Berhubungan Dengan Keluhan Nyeri Otot Rangka Pada Pemulung Di Lingkungan TPST RDF Kabupaten Cilacap
Authors: Poppi Nastasia Yunita Dewi  , Sofia Rakhmawati Nita , Kartika Estri , Hariyanto Saputro Didit 
Published: March 2023

Keluhan nyeri otot rangka merupakan serangkaian sakit atau cedera yang terjadi pada otot, tendon, tulang, ligamen, sendi, dan saraf mulai dari tingkat sangat ringan sampai sangat sakit yang disebut dengan Muskuloskeletal disorders (MSD). Keluhan nyeri otot rangka ini disebabkan oleh aktivitas dengan tingkat pengulangan yang tinggi dengan cara kerja yang tidak ergonomis. Penelitian ini bertujuan untuk mengetahui hubungan antara jenis kelamin, masa kerja, dan berat beban dengan keluhan nyeri otot rangka pada pemulung. Penelitian ini merupakan penelitian observasional analitik dengan metode pendekatan cross sectional. Hasil penelitian ini menunjukkan bahwa jenis kelamin paling banyak adalah perempuan sebesar 76,7%, masa kerja pemulung ? 5 tahun sebesar 77,1%, berat beban yang berisiko sebesar 10,5% dan keluhan nyeri otot rangka sebesar 63,2%. Analisis uji chi square test menunjukkan terdapat hubungan antara jenis kelamin (p: 0,026), masa kerja (p: 0,006), berat beban (p: 0,001) dengan keluhan nyeri otot rangka pada pemulung di TPST RDF Kabupaten Cilacap. Pemulung diharapkan tidak mengangkut beban sampah yang berlebihan, mengatur jam istirahat, dan menerapkan konsumsi gizi seimbang.
MITIGATE TYPE II AGENCY CONFLICT THROUGH GOOD CORPORATE GOVERNANCE AND DISCLOSURE QUALITY
Authors: Jatiningrum Citrawati , Fauzi Fauzi , Utami Bernaditha H.S , Kassim Aza Azlina Md 
Published: March 2023

Empirical evidence on type II conflicts between controlling shareholders versus minority shareholders has not been extensively explored. This study gives new evidence on the agency conflict in a scenario of highly concentrated ownership. This study aims to examine the effect of Good Corporate Governance mechanism with quality of disclosure on concentrated ownership context The sample were drawn from companies listed on the Indonesia Stock Exchange (IDX). The data were analyzed with panel data regression. The results shows that CG mechanisms negatively effects with DQ. However, looking at each individual variable, the study reveals that the audit committee and independence of audit committee are not significant. A possible reason is that companies' audit committee members have lack of accounting expertise and independence. These findings shed light on the concept of good CG enhances incentives for good DQ under highly concentrated ownership. It the effectiveness of CG mechanisms is likely to supplement regulation to protect investor rights and may prove to be useful for standard-setters as an important way to reduce agency conflicts.
Building a microcycle program for skiers using the kinesioplasty method
Authors: Gavriliuк V. , Boyko V. , Chaplygin V. , Zhyvollovych S. 
Published: March 2023

In the scientific and methodological literature, a great deal of respect was attached to the preparation of the kinesioplasty method during the folding of the training microcycles during the preparation to the final stage, or a series of starts on the singing stage during the final preparation.
At the statistics, there is an injection of a special-preparatory complex of rights for athletes using the kinesioplasty method with training of statodynamic stamina of athletes. Doslіdzhuvavsya infusion of this method on the rational budovu training process, scho to increase the functional capacity of the organs and systems of the body of the lizhniks and the full complex of mechanisms that are responsible for adaptation.
The kinesioplasty method was aimed at eliminating the athlete's physiological immaturity, regulating involuntary, spontaneous, micro-kinetic processes and their synchronization with consciously ordered structures in the direction of physiological optimality of pathological or newly formed functional systems in this sport. This helps to increase the degrees of freedom in the joints, and the athlete himself consistently gets the opportunity to implement systematic training motor activity.
Studies of the scientific and methodological literature in skiing indicate that upon reaching a high level of sports fitness, maximum indicators of internal inter-component correlations appear in athletes, and after the end of the competition period, they very quickly fall to levels lower than in the preparatory period.
Thus, in training races, it is important to take into account and develop special specific states of the body's functional systems of skiers.
Our research has shown that a significant contribution to the performance of skiers' sports activities is made by the translational system, the ability to maintain body balance through dynamic stabilization in relation to the gravity vector. The ability to maintain balance during the race determines the final result.
The study was conducted during September-December 2022 at the base of the children's and youth sports school of Skoliv OTG of the Lviv region. (n=16) participated in the study. During the research, the own method of kinesioplasty was introduced into the training microcycle, which was implemented by candidate of pedagogical sciences, associate professor V. Gavriliuк.