bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evidence of nerve agent VX exposure in rat plasma by detection of albumin-adducts in vitro and in vivo
Authors: Kranawetvogl Tamara , Kranawetvogl Andreas , Scheidegger Lisa , Wille Timo , Steinritz Dirk , Worek Franz , Thiermann Horst , John Harald 
Published: June 2023

AbstractVX is a highly toxic organophosphorus nerve agent that reacts with a variety of endogenous proteins such as serum albumin under formation of adducts that can be targeted by analytical methods for biomedical verification of exposure. Albumin is phosphonylated by the ethyl methylphosphonic acid moiety (EMP) of VX at various tyrosine residues. Additionally, the released leaving group of VX, 2-(diisopropylamino)ethanethiol (DPAET), may react with cysteine residues in diverse proteins. We developed and validated a microbore liquid chromatography-electrospray ionization high-resolution tandem mass spectrometry (µLC-ESI MS/HR MS) method enabling simultaneous detection of three albumin-derived biomarkers for the analysis of rat plasma. After pronase-catalyzed cleavage of rat plasma proteins single phosphonylated tyrosine residues (Tyr-EMP), the Cys34(-DPAET)Pro dipeptide as well as the rat-specific LeuProCys448(-DPAET) tripeptide were obtained. The time-dependent adduct formation in rat plasma was investigated in vitro and biomarker formation during proteolysis was optimized. Biomarkers were shown to be stable for a minimum of four freeze-and-thaw cycles and for at least 24 h in the autosampler at 15 °C thus making the adducts highly suited for bioanalysis. Cys34(-DPAET)Pro was superior compared to the other serum biomarkers considering the limit of identification and stability in plasma at 37 °C. For the first time, Cys34(-DPAET)Pro was detected in in vivo specimens showing a time-dependent concentration increase after subcutaneous exposure of rats underlining the benefit of the dipeptide disulfide biomarker for sensitive analysis.
Generalized Hasimoto-type surfaces of null growth in Minkowski 3-space
Authors: Qian Jinhua , Li Yawen , Fu Xueshan 
Published: June 2023

AbstractIn this article, the idea of the generalized Hasimoto-type surfaces are put forward based on the interaction between vortex filaments. Meanwhie, the surface of null growth is proposed by evolving a null curve as dictated direction and growth velocity in Minkowski 3-space. The conditions and geometric forms of the generalized Hasimoto-type surfaces of null growth are investigated. Last but not least, several typical examples are presented to characterize such surface growth and the corresponding perturbations explicitly.
Comparison of edoxaban and enoxaparin in a rat model of AlCl3-induced thrombosis of the superior sagittal sinus
Authors: Hachenberger M. , Yeniguen M. , Suenner L. , Hinchliffe D. , Mueller C. , Wietelmann A. , Gerriets T. , Tschernatsch M. , Juenemann M. , Gerner S. T. , Doeppner T. R. , Huttner H. B. , Braun T. 
Published: June 2023

Abstract
Cerebral sinus venous thrombosis (CSVT) is an uncommon disease that is usually treated with anticoagulation (heparin, low-molecular heparin, or vitamin K-antagonists). We compared treatment with edoxaban, an oral factor Xa-antagonist, that has not been approved in patients with CSVT, with enoxaparin, a well-established therapy, in a rat model of CSVT. Fifty male Wistar rats were randomized into 5 groups (10 animals each) and subjected to aluminum chloride (AlCl3)-induced thrombosis of the superior sagittal sinus (SSS) or sham procedure. Animals with thrombosis of the SSS were treated with edoxaban, enoxaparin, or placebo. Diagnostic workup included neurological examination, MRI imaging, MR-flow measurements of the SSS, and immunohistochemical staining. Neurological examination revealed no differences between treatment groups. Seven days after initial thrombosis, flow in the SSS was lower in the active treatment group as compared to sham-operated animals (p < 0.05). Flow in the SSS in the active treatment groups (edoxaban 1 h prior to thrombosis: 0.16 cm/s ± 0.06 cm/s; edoxaban 6 h after thrombosis: 0.13 cm/s ± 0.05 cm/s; enoxaparin: 0.13 cm/s ± 0.04 cm/s; placebo: 0.07 cm/s ± 0.02 cm/s) was higher as compared to placebo (p < 0.05), but there were no differences between the active treatment groups (p > 0.05). Immunohistochemical staining showed no differences in the actively treated animals. Edoxaban proved to be similar to enoxaparin in a model of experimental AlCl3-induced CSVT.
Age-related prevalence and imaging characteristics of the superior acetabular roof notch in children, adolescents, and young adults
Authors: Dietrich Tobias Johannes , Vaeth Desiree , Wildermuth Simon , Waelti Stephan , Leschka Sebastian , Graf Nicole , Fischer Tim 
Published: June 2023

Abstract
Objective
To determine the age-related prevalence and imaging characteristics of the superior acetabular roof notch (SARN) on hip MRI and radiographs in a young study population.

Materials and methods
Retrospective analysis of 304 MRI examinations and corresponding available radiographs of patients between the ages of 4 and 24 years. Two observers classified SARN with fluid-like findings on MRI as type-1, whereas SARN with fat-like findings on MRI were classified as type-2. Sensitivity and specificity of radiographic SARN findings were determined using MRI as the reference standard. Logistic regression models were used to assess the age-related prevalence on MRI.

Results
Twelve patients (3.9%) had fluid-like SARN type-1, 27 patients (8.9%) had fat-like SARN type-2, while 265 patients (87.2%) had no SARN on MRI. The odds ratio (OR) for age (years) with respect to the presence of a fluid-like SARN type-1 on MRI was 0.79 (95% CI: 0.70–0.89), meaning that with each year, the likelihood for SARN type-1 decreased by 21% (p < 0.001). The OR for age with respect to the presence of a fat-like SARN type-2 on MRI was 1.14 (95% CI: 1.02–1.27) (p = 0.017). The diagnostic sensitivity for detecting a SARN on radiographs compared to MRI as the reference standard was between 0.75 and 0.83 and the corresponding specificity was between 0.85 and 0.89 for both observers.

Conclusion
SARN is a common finding on MRI and radiographs. The present data suggest that SARN undergoes an age-related imaging characteristic from a fluid-like appearance to a fat-like appearance on MRI during adolescence.
Enhanced Recovery After Surgery (ERAS) Pathways for Aesthetic Breast Surgery: A Prospective Cohort Study on Patient-Reported Outcomes
Authors: Stahl Stéphane , Santos Stahl Adelana , Feng You-Shan , Estler Arne , Buiculescu Florian , Seabra Robalo Gomes Jorge Ana Cristina 
Published: June 2023

Abstract
Background
Patients’ expectations of an anticipated timeline of recovery and fear of anesthesia in aesthetic breast surgery have not been studied.

Objective
This study aims to assess patient anxiety, expectations, and satisfaction after Enhanced Recovery after Surgery (ERAS) pathways for aesthetic breast surgery and the progress of postoperative recovery.

Materials and methods
All consecutive patients who underwent aesthetic breast surgery between April 2021 and August 2022 were included in this single-center prospective cohort study. The ERAS protocol consists of more than 20 individual measures in the pre-, intra-, and postoperative period. Epidemiological data, expectations, and recovery were systematically assessed with standardized self-assessment questionnaires, including the International Pain Outcome Questionnaire (IPO), the BREAST-Q or BODY-Q, and data collection forms.

Results
In total, 48 patients with a median of 30 years of age were included. Patients returned to most daily activities within 5 days. Eighty-eight percent of patients were able to accomplish daily activities sooner than expected. The time of return to normal daily activities was similar across all procedure types. There was no statistically significant difference regarding postoperative satisfaction between patients who recovered slower (12%) and patients who recovered as fast or faster (88%) than anticipated (p=0.180). Patients reporting fear of anesthesia in the form of conscious sedation significantly diminished from 17 to 4% postoperatively (p<0.001).

Conclusion
Enhanced Recovery after Surgery (ERAS) pathways for aesthetic breast surgery are associated with rapid recovery and high patient satisfaction. This survey study provides valuable insight into patients’ concerns and perspectives that may be implemented in patient education and consultations to improve patient satisfaction following aesthetic treatments.

Level of Evidence IV
This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.
Parental perceptions and experiences of care in the surgical neonatal intensive care unit
Authors: Lam Jennifer Y. , Howlett Alexandra , Stephen Lori M. , Brindle Mary E. 
Published: June 2023

Abstract
Background
Parents endure significant stress when their newborns require surgery while in the neonatal intensive care unit (NICU). Our study aims to explore the surgical NICU experience from the parents’ perspective and identify areas that may improve this experience. A secondary objective was to integrate their feedback to refine the implementation strategy of the neonatal enhanced recovery after surgery (ERAS®) guideline.

Methods
In December 2019, five surgical NICU parents participated in a focus group. Conversation surrounded parents’ perspectives and experiences of the surgical NICU. Inductive analysis was performed to identify data, themes, and concepts that emerged from the discussion.

Results
Participants identified four major interrelated themes that impacted the surgical parents’ NICU experience. These themes include (1) parental state, both physical and emotional, (2) the altered parental caregiver role which necessitates identifying alternative meaningful parental experiences, (3) the care team dynamic, incorporating consistency and effective communication, and (4) the discharge process which may be significantly eased through graduated, hands-on training.

Conclusion
Key elements of the neonatal ERAS® guideline address major themes and stressors identified by parents. The parental perspective may help clinicians appreciate the parent surgical NICU experience and assist in improving family-centered care to surgical infants and their families.
Importance of interdisciplinarity in modern oncology: results of a national intergroup survey of the Young Oncologists United (YOU)
Authors: Mäurer Matthias , Staudacher Jonas , Meyer Robert , Mäurer Irina , Lazaridis Lazaros , Müther Michael , Huber Tobias , Sommer Nils P. , Fleischmann Daniel F. , Käsmann Lukas , Ziegler Sonia , Kropf-Sanchen Cornelia , Wikert Julia , Pietzner Klaus , Holzgreve Adrien , Nestler Tim , Siech Carolin , Sturm Max-Johann , Sulzer Sabrina , Heinrich Kathrin , Stahler Arndt ,   on behalf of the Young Oncologists United (YOU)
Published: June 2023

Abstract
Purpose
Modern, personalized treatment concepts in oncology require an interdisciplinary and multiprofessional collaboration. In addition to its relevance in patient care, interdisciplinary collaboration is also becoming increasingly important in clinical research as well as medical education and resident training in oncology.

Methods
Between November 2021 and March 2022, an online survey was conducted among German early career research groups, represented by Young Oncologists United (YOU). The aim was to identify the status and need for interdisciplinarity at clinic, educational, and research levels.

Results
A total of 294 participants completed the questionnaire in full. 90.7% of the respondents fully or predominantly agreed with the statement that interdisciplinary work plays a major role in their daily clinical work. 78.9% wished for more interdisciplinary collaboration. Of the 49.7% of participants who have never participated in an interdisciplinary research project, 80.1% said they would like to participate in such a study project in the future. Lack of time resources, too much organizational effort, and possible political conflicts between institutions were identified as factors that make practical implementation difficult. 74.1% declared their willingness to become active in an oncology early career research group.

Conclusion
Interdisciplinary collaboration has become increasingly important in oncology. Networks that span different disciplines could help to promote interdisciplinary research projects among young scientists and improve exchange in professional practice and education with the implication of improved patient care.
The relative importance of abiotic and biotic environmental conditions for taxonomic, phylogenetic, and functional diversity of spiders across spatial scales
Authors: Måsviken Johannes , Dalén Love , Norén Karin , Dalerum Fredrik 
Published: June 2023

AbstractBoth abiotic and biotic conditions may be important for biodiversity. However, their relative importance may vary among different diversity dimensions as well as across spatial scales. Spiders (Araneae) offer an ecologically relevant system for evaluating variation in the relative strength abiotic and biotic biodiversity regulation. We quantified the relative importance of abiotic and biotic conditions for three diversity dimensions of spider communities quantified across two spatial scales. Spiders were surveyed along elevation gradients in northern Sweden. We focused our analysis on geomorphological and climatic conditions as well as vegetation characteristics, and quantified the relative importance of these conditions for the taxonomic, phylogenetic, and functional diversity of spider communities sampled across one intermediate (500 m) and one local (25 m) scale. There were stronger relationships among diversity dimensions at the local than the intermediate scale. There were also variation in the relative influence of abiotic and biotic conditions among diversity dimensions, but this variation was not consistent across spatial scales. Across both spatial scales, vegetation was related to all diversity dimensions whereas climate was important for phylogenetic and functional diversity. Our study does not fully support stronger abiotic regulation at coarser scales, and conversely stronger abiotic regulation at more local scales. Instead, our results indicate that community assembly is shaped by interactions between abiotic constrains in species distributions and biotic conditions, and that such interactions may be both scale and context dependent.
The correlation between serum uric acid and diabetic kidney disease in adult-onset type 1 diabetes patients in China
Authors: Jiang Jun , Zhou Xiaowan , Lan Lei , Weng Jianping , Ren Wei 
Published: June 2023

Abstract
Background/aim
To assess the correlation between serum uric acid (UA) level and diabetic kidney disease among adult-onset Type 1 diabetes mellitus (T1DM) patients in China.

Methods
A total of 184 patients with adult-onset T1DM between January 2014 and December 2016 were recruited, with demographics and medical data collected. Comparisons were performed between according to different serum UA gender-specific quartiles. Relationship between serum UA level with urinary ACR and eGFR was also assessed.

Results
Median urinary ACR and eGFR were 21.55 [10.79, 45.02] mg/g and 113.86 [88.43, 143.61] ml/min/1.73 m2, respectively. The median UA was 257.4 (208.2–334.8) μmol/L. Participants with higher serum UA levels had higher urinary ACR and lower eGFR than those with lower UA (P < 0.05). Higher serum UA level was significantly associated with higher urinary ACR in Spearman's correlational analysis (P = 0.006) and multiple stepwise regression analysis (P = 0.013). The association between serum UA and urinary ACR was not linear, but showed a curve correlation, which also showed in the sensitivity analysis. Serum UA in the upper gender-specific quartile, was associated with lower eGFR (P < 0.001) and showed an independent negative correlation with eGFR in multiple stepwise regression analysis (P < 0.001).

Conclusions
The serum UA level was negatively correlated with eGFR and had a curve correlation with urinary ACR in adult-onset T1DM patients of China.
SARS-CoV-2 and the nervous system: current perspectives
Authors: Pattanaik Amrita , Bhandarkar B Sushma , Lodha Lonika , Marate Srilatha 
Published: June 2023

AbstractSARS-CoV-2 infection frequently causes neurological impairment in both adults and children. Recent publications have described significant aspects of the viral pathophysiology associated with neurological dysfunction. In theory, neurological manifestations following SARS-CoV-2 infection may be caused directly by the effects of the virus infecting the brain or indirectly by the local and systemic immune responses against the virus. Neurological manifestations can occur during the acute phase as well as in the post-acute phase of the infection. In this review, we discuss recent literature describing the association of nervous system disorders with COVID-19.
Ciao AI: the Italian adaptation and validation of the Chatbot Usability Scale
Authors: Borsci Simone , Prati Elisa , Malizia Alessio , Schmettow Martin , Chamberlain Alan , Federici Stefano 
Published: June 2023

AbstractChatbot-based tools are becoming pervasive in multiple domains from commercial websites to rehabilitation applications. Only recently, an eleven-item satisfaction inventory was developed (the ChatBot Usability Scale, BUS-11) to help designers in the assessment process of their systems. The BUS-11 has been validated in multiple contexts and languages, i.e., English, German, Dutch, and Spanish. This scale forms a solid platform enabling designers to rapidly assess chatbots both during and after the design process. The present work aims to adapt and validate the BUS-11 inventory in Italian. A total of 1360 questionnaires were collected which related to a total of 10 Italian chatbot-based systems using the BUS-11 inventory and also using the lite version of the Usability Metrics for User eXperience for convergent validity purposes. The Italian version of the BUS-11 was adapted in terms of the wording of one item, and a Multi-Group Confirmatory Factorial Analysis was performed to establish the factorial structure of the scale and compare the effects of the wording adaptation. Results indicate that the adapted Italian version of the scale matches the expected factorial structure of the original scale. The Italian BUS-11 is highly reliable (Cronbach alpha: 0.921), and it correlates to other measures of satisfaction (e.g., UMUX-Lite, τb = 0.67; p < .001) by also offering specific insights regarding the chatbots’ characteristics. The Italian BUS-11 can be confidently used by chatbot designers to assess the satisfaction of their users during formative or summative tests.
Adapting to sea level rise: participatory, solution-oriented policy tools in vulnerable Mediterranean areas
Authors: Loizidou Xenia I. , L. Orthodoxou Demetra , I. Loizides Michael , Petsa Demetra , Anzidei Marco 
Published: June 2023

AbstractThe coasts of the Mediterranean basin are exposed to the ongoing effects of climate change and anthropogenic pressure. Low elevated coastal plains, river deltas, lagoons and reclamation areas are experiencing beach retreat, coastal erosion and marine flooding. This makes them particularly vulnerable to sea level rise (SLR), which is expected to increase up to 1 m by 2100 AD, according to the projections of the Intergovernmental Panel on Climate Change. In this study, selected stakeholders from four Mediterranean coastal areas that are highly vulnerable to the impacts of SLR have been engaged through a structured participatory process for the development of solution-oriented, case-specific and site-specific Policy Tools to address SLR. The developed Policy Tools for the Venice Lagoon, the Metaponto reclamation area and the Basento river mouth, in Italy, the Ebro River Delta in Spain, and the coastal plain of Chalastra, near the Axios River Delta, in Greece, contain relevant, effective and implementable actions stemming from stakeholder interaction and consensus building. The interconnected stakeholder engagement steps employed in this study identified relevant issues that should be considered when defining SLR adaptation policies to bridge knowledge and perception gaps, facilitate knowledge exchange and foster social learning through structured science communication on SLR. This participatory stakeholder process can lay the foundations for more extensive participation in public processes through which the resulting Policy Tools can materialise into collectively accepted, concrete actions to help vulnerable areas adapt to the expected SLR and consequent coastal hazards by the end of this century.
A Novel Warning Identification Framework for Risk-Informed Anomaly Detection
Authors: Spahic Rialda , Hepsø Vidar , Lundteigen Mary Ann 
Published: June 2023

Abstract
Cyber-physical systems are taking on a permanent role in the industry, such as in oil and gas or mining. These systems are expected to perform increasingly autonomous tasks in complex settings removing human operators from remote and potentially hazardous environments. High autonomy necessitates a more extensive use of artificial intelligence methods, such as anomaly detection, to identify unusual occurrences in the monitored environment. The absence of data characterizing potentially hazardous events leads to disruptive noise displayed as false alarms, a common anomaly detection issue for hazard identification applications. Contrastingly, disregarding the false alarms can result in the opposite effect, causing loss of early indications of hazardous occurrences. Existing research introduces simulating and extrapolating less represented data to expand the information on hazards and semi-supervise the methods or by introducing thresholds and rule-based methods to balance noise and meaningful information, necessitating intensive computing resources. This research proposes a novel Warning Identification Framework that evaluates risk analysis objectives and applies them to discern between true and false warnings identified by anomaly detection. We demonstrate the results by analyzing three seismic hazard assessment methods for identifying seismic tremors and comparing the outcomes to anomalies found using the unsupervised anomaly detection method. The demonstrated approach shows great potential in enhancing the reliability and transparency of anomaly detection outcomes and, thus, supporting the operational decision-making process of a cyber-physical system.