bluuebunny/crossref_metadata_2025_split huggingface dataset:
Video2Flink: real-time video partitioning in Apache Flink and the cloud
Authors: Kastrinakis Dimitrios , Petrakis Euripides G. M. 
Published: April 2023

AbstractVideo2Flink is a distributed highly scalable video processing system for bounded (i.e., stored) or unbounded (i.e., continuous) and real-time video streams with the same efficiency. It shows how complicated video processing tasks can be expressed and executed as pipelined data flows on Apache Flink, an open-source stream processing platform. Video2Flink uses Apache Kafka to facilitate the machine-to-machine (m2m) communication between the video production and the video processing system that runs on Apache Flink. Features that make the combination of Apache Kafka and Apache Flink a desirable solution to the problem of video processing are the ease of customization, portability, scalability, and fault tolerance. The application is deployed on a Flink cluster of worker machines that run on Kubernetes in the Google Cloud Platform. The experimental results support our claims of speed showing excellent speed-up results for all tested video resolutions. The highest (i.e., more than seven times) speed-up was observed with the videos of the highest resolutions and in real time.
Minimal Acceleration for the Multi-dimensional Isentropic Euler Equations
Authors: Westdickenberg Michael 
Published: April 2023

AbstractOn the set of dissipative solutions to the multi-dimensional isentropic Euler equations, we introduce a quasi-order by comparing the acceleration at all time. This quasi-order is continuous with respect to a suitable notion of convergence of dissipative solutions. We establish the existence of minimal elements. Minimizing the acceleration amounts to selecting dissipative solutions that are as close to being a weak solution as possible.
Changes in anthocyanin pigments, trans-resveratrol, and colorimetric characteristics of Fondillón wine and other “Monastrell” wines during the aging period
Authors: Uysal Reyhan Selin , Issa-Issa Hanán , Sendra Esther , Carbonell-Barrachina Ángel A. 
Published: April 2023

AbstractThe studied red wines, which are Fondillón, reserva, crianza, and young, are prepared from exclusive “Monastrell” grapes, and protected under the Alicante Denomination of Origin (Alicante, Spain). The objectives of the present study were (i) to show the effect of aging period on the amount of anthocyanin pigments, trans-resveratrol, and the colorimetric characteristics (color intensity, color density, and tonality) of Fondillón and other Monastrell wines (young, crianza, and reserva) which have different aging periods, and (ii) to propose a new traceability method for the determination of the Fondillón originality. Identification of anthocyanin compounds and determination of trans-resveratrol content were performed using LC–MS/MS. Correlation analysis was performed among anthocyanin compounds and color parameters. A sharp decrease in the anthocyanins content was observed in Fondillón wine. Besides, statistically significant changes were found in all colorimetric parameters between young and Fondillón samples. A significant change from red hue to brick red/yellow hue was observed between the colors of young and Fondillón wines, respectively. A significant decrease in the content of trans-resveratrol was also observed as a result of the aging period of these “Monastrell” wines. In this study, anthocyanin compounds of Fondillón wine were identified for the first time and their effects on the colorimetric parameters of the wine were revealed. Consequently, the authenticity of Fondillón wines can be determined by monitoring of anthocyanin compounds and trans-resveratrol.
Spatial cumulant models enable spatially informed treatment strategies and analysis of local interactions in cancer systems
Authors: Hamis Sara , Somervuo Panu , Ågren J. Arvid , Tadele Dagim Shiferaw , Kesseli Juha , Scott Jacob G. , Nykter Matti , Gerlee Philip , Finkelshtein Dmitri , Ovaskainen Otso 
Published: April 2023

AbstractTheoretical and applied cancer studies that use individual-based models (IBMs) have been limited by the lack of a mathematical formulation that enables rigorous analysis of these models. However, spatial cumulant models (SCMs), which have arisen from theoretical ecology, describe population dynamics generated by a specific family of IBMs, namely spatio-temporal point processes (STPPs). SCMs are spatially resolved population models formulated by a system of differential equations that approximate the dynamics of two STPP-generated summary statistics: first-order spatial cumulants (densities), and second-order spatial cumulants (spatial covariances). We exemplify how SCMs can be used in mathematical oncology by modelling theoretical cancer cell populations comprising interacting growth factor-producing and non-producing cells. To formulate model equations, we use computational tools that enable the generation of STPPs, SCMs and mean-field population models (MFPMs) from user-defined model descriptions (Cornell et al. Nat Commun 10:4716, 2019). To calculate and compare STPP, SCM and MFPM-generated summary statistics, we develop an application-agnostic computational pipeline. Our results demonstrate that SCMs can capture STPP-generated population density dynamics, even when MFPMs fail to do so. From both MFPM and SCM equations, we derive treatment-induced death rates required to achieve non-growing cell populations. When testing these treatment strategies in STPP-generated cell populations, our results demonstrate that SCM-informed strategies outperform MFPM-informed strategies in terms of inhibiting population growths. We thus demonstrate that SCMs provide a new framework in which to study cell-cell interactions, and can be used to describe and perturb STPP-generated cell population dynamics. We, therefore, argue that SCMs can be used to increase IBMs’ applicability in cancer research.
Positive contribution of hydroxytyrosol-enriched wheat bread to HbA1c levels, lipid profile, markers of inflammation and body weight in subjects with overweight/obesity and type 2 diabetes mellitus
Authors: Binou Panagiota , Stergiou Athena , Kosta Ourania , Tentolouris Nikolaos , Karathanos Vaios T. 
Published: April 2023

Abstract
Purpose
The aim of the present study was to assess the impact of the daily consumption of bread enriched with hydroxytyrosol on HbA1c and blood lipid levels, inflammatory markers and weight loss.

Methods
Sixty adults with overweight/obesity and type 2 diabetes mellitus (29 male, 31 female) participated in a 12-week dietary intervention based on the Mediterranean diet and consumed daily 60 g of conventional whole wheat bread (WWB) or whole wheat bread enriched with hydroxytyrosol (HTB). Anthropometric characteristics were measured and venous blood samples were collected at baseline and at the end of the intervention.

Results
Both groups experienced significant weight loss, body fat and waist circumference decrease (p < 0.001). Nonetheless, a greater body fat mass decrease was observed in the HTB group compared to the WWB group (14.4 ± 1.6 vs 10.2 ± 1.1%, p = 0.038). Significant reductions were also reported in fasting glucose, HbA1c and blood pressure in both groups (p < 0.05). Regarding glucose and HbA1c, greater decreases were observed in the intervention group (101.4 ± 19.9 vs. 123.2 ± 43.4 mg/dL, p = 0.015 and 6.0 ± 0.6 vs. 6.4 ± 0.9%, p = 0.093, respectively). At HTB group, significant reductions in blood lipid, insulin, TNF-αand adiponectin levels (p < 0.05) and a marginally significant reduction in leptin levels (p = 0.081) were also reported.

Conclusion
Enrichment of bread with HT resulted in significant body fat mass reduction and positive effects on fasting glucose, insulin and HbA1c levels. It also contributed to reductions in inflammatory markers and blood lipid levels. Incorporation of HT in staple foods, like bread, may improve their nutritional profile and, in terms of a balanced diet, may contribute to the management of chronic diseases.

Trial registration
The study was prospectively registered in clinicaltrials.gov (24th May 2021). ClinicalTrials.gov Identifier: NCT04899791.
Impact of template-based synoptic reporting on completeness of surgical pathology reports
Authors: Schaad Nicole , Berezowska Sabina , Perren Aurel , Hewer Ekkehard 
Published: April 2023

AbstractSynoptic reporting increases completeness and standardization of surgical pathology reports and thereby contributes to an increased quality of clinical cancer care. Nevertheless, its widespread practical implementation remains a challenge, which is in part related to the effort required for setup and maintenance of database structures. This prompted us to assess the effect of a simple template-based, database-free system for synoptic reporting on completeness of surgical pathology reports. For this purpose, we analyzed 200 synoptic reports (100 colon and 100 lung cancer resections each) for completeness as required by the pertinent College of American Pathologists (CAP) protocols and compared these to a control dataset of 200 narrative reports. Introduction of template-based synoptic reporting resulted in improved completeness (98% of mandatory data elements) as compared to narrative reports (77%). Narrative reports showed a high degree of completeness for data elements covered by previously existing dictation templates. In conclusion, template-based synoptic reporting without underlying database structure can be a useful transitory phase in the implementation of synoptic reporting. It can result in a similar degree of completeness as reported in the literature for database solutions and provides other benefits of synoptic reporting while facilitating its implementation.
Creating and validating a scholarly knowledge graph using natural language processing and microtask crowdsourcing
Authors: Oelen Allard , Stocker Markus , Auer Sören 
Published: April 2023

AbstractDue to the growing number of scholarly publications, finding relevant articles becomes increasingly difficult. Scholarly knowledge graphs can be used to organize the scholarly knowledge presented within those publications and represent them in machine-readable formats. Natural language processing (NLP) provides scalable methods to automatically extract knowledge from articles and populate scholarly knowledge graphs. However, NLP extraction is generally not sufficiently accurate and, thus, fails to generate high granularity quality data. In this work, we present TinyGenius, a methodology to validate NLP-extracted scholarly knowledge statements using microtasks performed with crowdsourcing. TinyGenius is employed to populate a paper-centric knowledge graph, using five distinct NLP methods. We extend our previous work of the TinyGenius methodology in various ways. Specifically, we discuss the NLP tasks in more detail and include an explanation of the data model. Moreover, we present a user evaluation where participants validate the generated NLP statements. The results indicate that employing microtasks for statement validation is a promising approach despite the varying participant agreement for different microtasks.
Profile of the multicenter cohort of the German Cancer Consortium’s Clinical Communication Platform
Authors: Maier Daniel , Vehreschild Jörg Janne , Uhl Barbara , Meyer Sandra , Berger-Thürmel Karin , Boerries Melanie , Braren Rickmer , Grünwald Viktor , Hadaschik Boris , Palm Stefan , Singer Susanne , Stuschke Martin , Juárez David , Delpy Pierre , Lambarki Mohamed , Hummel Michael , Engels Cäcilia , Andreas Stefanie , Gökbuget Nicola , Ihrig Kristina , Burock Susen , Keune Dietmar , Eggert Angelika , Keilholz Ulrich , Schulz Hagen , Büttner Daniel , Löck Steffen , Krause Mechthild , Esins Mirko , Ressing Frank , Schuler Martin , Brandts Christian , Brucker Daniel P. , Husmann Gabriele , Oellerich Thomas , Metzger Patrick , Voigt Frederik , Illert Anna L. , Theobald Matthias , Kindler Thomas , Sudhof Ursula , Reckmann Achim , Schwinghammer Felix , Nasseh Daniel , Weichert Wilko , von Bergwelt-Baildon Michael , Bitzer Michael , Malek Nisar , Öner Öznur , Schulze-Osthoff Klaus , Bartels Stefan , Haier Jörg , Ammann Raimund , Schmidt Anja Franziska , Guenther Bernd , Janning Melanie , Kasper Bernd , Loges Sonja , Stilgenbauer Stephan , Kuhn Peter , Tausch Eugen , Runow Silvana , Kerscher Alexander , Neumann Michael , Breu Martin , Lablans Martin , Serve Hubert 
Published: April 2023

AbstractTreatment concepts in oncology are becoming increasingly personalized and diverse. Successively, changes in standards of care mandate continuous monitoring of patient pathways and clinical outcomes based on large, representative real-world data. The German Cancer Consortium’s (DKTK) Clinical Communication Platform (CCP) provides such opportunity. Connecting fourteen university hospital-based cancer centers, the CCP relies on a federated IT-infrastructure sourcing data from facility-based cancer registry units and biobanks. Federated analyses resulted in a cohort of 600,915 patients, out of which 232,991 were incident since 2013 and for which a comprehensive documentation is available. Next to demographic data (i.e., age at diagnosis: 2.0% 0–20 years, 8.3% 21–40 years, 30.9% 41–60 years, 50.1% 61–80 years, 8.8% 81+ years; and gender: 45.2% female, 54.7% male, 0.1% other) and diagnoses (five most frequent tumor origins: 22,523 prostate, 18,409 breast, 15,575 lung, 13,964 skin/malignant melanoma, 9005 brain), the cohort dataset contains information about therapeutic interventions and response assessments and is connected to 287,883 liquid and tissue biosamples. Focusing on diagnoses and therapy-sequences, showcase analyses of diagnosis-specific sub-cohorts (pancreas, larynx, kidney, thyroid gland) demonstrate the analytical opportunities offered by the cohort’s data. Due to its data granularity and size, the cohort is a potential catalyst for translational cancer research. It provides rapid access to comprehensive patient groups and may improve the understanding of the clinical course of various (even rare) malignancies. Therefore, the cohort may serve as a decisions-making tool for clinical trial design and contributes to the evaluation of scientific findings under real-world conditions.
Taylorism on steroids or enabling autonomy? A systematic review of algorithmic management
Authors: Noponen Niilo , Feshchenko Polina , Auvinen Tommi , Luoma-aho Vilma , Abrahamsson Pekka 
Published: April 2023

AbstractThe use of algorithmic management systems is rapidly changing organizational models and practices, as millions of workers in multiple sectors worldwide are managed by computer software. Despite receiving increasing academic interest, little summarizing literature exist on the ways algorithmic systems are used in management. This article aims to fill this gap by systematically reviewing and qualitatively analyzing 172 articles on the topic. Our research contributes to the existent algorithmic management literature in three ways. First, we provide a descriptive overview of algorithmic management as a field of research. Second, we identify and synthesize the discussion on the key concepts of the topic, namely how algorithmic management: (1) simultaneously restrains and enables workers’ autonomy—yet income dependency and other factors force inflexible work practices; (2) creates a complex, digital version of Taylorism; and (3) creates new and changes existing organizational power structures. Third, as our main theoretical contribution, we create the framework of Algorithmic Management Grid that demonstrates the ways in which organizations use algorithmic systems in management. The Algorithmic Management Grid illustrates how, in both novel and traditional organizational models, algorithmic management may be used with emphasis either on controlling or enabling workers. Based on the reviewed literature, we claim that so far, companies have mostly utilized algorithmic systems in a controlling manner, neglecting the technology’s enabling potential in organizing.
Purinergic Tuning of the Tripartite Neuromuscular Synapse
Authors: Sousa-Soares Carlos , Noronha-Matos José Bernardo , Correia-de-Sá Paulo 
Published: April 2023

AbstractThe vertebrate neuromuscular junction (NMJ) is a specialised chemical synapse involved in the transmission of bioelectric signals between a motor neuron and a skeletal muscle fiber, leading to muscle contraction. Typically, the NMJ is a tripartite synapse comprising (a) a presynaptic region represented by the motor nerve ending, (b) a postsynaptic skeletal motor endplate area, and (c) perisynaptic Schwann cells (PSCs) that shield the motor nerve terminal. Increasing evidence points towards the role of PSCs in the maintenance and control of neuromuscular integrity, transmission, and plasticity. Acetylcholine (ACh) is the main neurotransmitter at the vertebrate skeletal NMJ, and its role is fine-tuned by co-released purinergic neuromodulators, like adenosine 5′-triphosphate (ATP) and its metabolite adenosine (ADO). Adenine nucleotides modulate transmitter release and expression of postsynaptic ACh receptors at motor synapses via the activation of P2Y and P2X receptors. Endogenously generated ADO modulates ACh release by acting via co-localised inhibitory A1 and facilitatory A2A receptors on motor nerve terminals, whose tonic activation depends on the neuronal firing pattern and their interplay with cholinergic receptors and neuropeptides. Thus, the concerted action of adenine nucleotides, ADO, and ACh/neuropeptide co-transmitters is paramount to adapting the neuromuscular transmission to the working load under pathological conditions, like Myasthenia gravis. Unravelling these functional complexities prompted us to review our knowledge about the way purines orchestrate neuromuscular transmission and plasticity in light of the tripartite synapse concept, emphasising the often-forgotten role of PSCs in this context.
Physiology-guided PCI versus CABG for left main coronary artery disease: insights from the DEFINE-LM registry
Authors: Warisawa Takayuki , Cook Christopher M. , Kawase Yoshiaki , Howard James P. , Ahmad Yousif , Seligman Henry , Rajkumar Christopher , Toya Takumi , Doi Shunichi , Nakajima Akihiro , Tanigaki Toru , Omori Hiroyuki , Nakayama Masafumi , Vera-Urquiza Rafael , Yuasa Sonoka , Sato Takao , Kikuta Yuetsu , Nishina Hidetaka , Al-Lamee Rasha , Sen Sayan , Lerman Amir , Akashi Yoshihiro J. , Escaned Javier , Matsuo Hitoshi , Davies Justin E. 
Published: April 2023

AbstractThere have been no studies comparing clinical outcomes of physiology-guided revascularization in patients with unprotected left main coronary disease (ULMD) between percutaneous coronary intervention (PCI) vs. coronary artery bypass grafting (CABG). The aim of this study was to assess the long-term clinical outcomes between PCI and CABG of patients with physiologically significant ULMD. From an international multicenter registry of ULMD patients interrogated with instantaneous wave-free ratio (iFR), we analyzed data from 151 patients (85 PCI vs. 66 CABG) who underwent revascularization according to the cutoff value of iFR ≤ 0.89. Propensity score matching was employed to adjust for baseline clinical characteristics. The primary endpoint was a composite of all-cause death, non-fatal myocardial infarction, and ischemia-driven target lesion revascularization. The secondary endpoints were the individual components of the primary endpoint. Mean age was 66.6 (± 9.2) years, 79.2% male. Mean SYNTAX score was 22.6 (± 8.4) and median iFR was 0.83 (IQR 0.74–0.87). After performing propensity score matching analysis, 48 patients treated with CABG were matched to those who underwent PCI. At a median follow-up period of 2.8 years, the primary endpoint occurred in 8.3% in PCI group and 20.8% in CABG group, respectively (HR 3.80; 95% CI 1.04–13.9; p = 0.043). There was no difference in each component of the primary event (p > 0.05 for all). Within the present study, iFR-guided PCI was associated with lower cardiovascular events rate in patients with ULMD and intermediate SYNTAX score, as compared to CABG.
Graphical abstract
State-of-the-art PCI vs. CABG for ULMD. Study design and primary endpoint in patients with physiologically significant ULMD. MACE was defined as the composite of all-cause death, non-fatal myocardial infarction, and target lesion revascularization. The blue line denotes the PCI arm, and the red line denotes the CABG arm. PCI was associated with significantly lower risk of MACE than CABG. CABG: coronary artery bypass grafting; iFR: instantaneous wave-free ratio; MACE: major adverse cardiovascular events; PCI: percutaneous coronary intervention; ULMD: unprotected left main coronary artery disease.
Small extracellular vesicles promote invadopodia activity in glioblastoma cells in a therapy-dependent manner
Authors: Whitehead Clarissa A. , Fang Haoyun , Su Huaqi , Morokoff Andrew P. , Kaye Andrew H. , Hanssen Eric , Nowell Cameron J. , Drummond Katharine J. , Greening David W. , Vella Laura J. , Mantamadiotis Theo , Stylli Stanley S. 
Published: April 2023

Abstract
Purpose
The therapeutic efficacy of radiotherapy/temozolomide treatment for glioblastoma (GBM) is limited by the augmented invasiveness mediated by invadopodia activity of surviving GBM cells. As yet, however the underlying mechanisms remain poorly understood. Due to their ability to transport oncogenic material between cells, small extracellular vesicles (sEVs) have emerged as key mediators of tumour progression. We hypothesize that the sustained growth and invasion of cancer cells depends on bidirectional sEV-mediated cell–cell communication.

Methods
Invadopodia assays and zymography gels were used to examine the invadopodia activity capacity of GBM cells. Differential ultracentrifugation was utilized to isolate sEVs from conditioned medium and proteomic analyses were conducted on both GBM cell lines and their sEVs to determine the cargo present within the sEVs. In addition, the impact of radiotherapy and temozolomide treatment of GBM cells was studied.

Results
We found that GBM cells form active invadopodia and secrete sEVs containing the matrix metalloproteinase MMP-2. Subsequent proteomic studies revealed the presence of an invadopodia-related protein sEV cargo and that sEVs from highly invadopodia active GBM cells (LN229) increase invadopodia activity in sEV recipient GBM cells. We also found that GBM cells displayed increases in invadopodia activity and sEV secretion post radiation/temozolomide treatment. Together, these data reveal a relationship between invadopodia and sEV composition/secretion/uptake in promoting the invasiveness of GBM cells.

Conclusions
Our data indicate that sEVs secreted by GBM cells can facilitate tumour invasion by promoting invadopodia activity in recipient cells, which may be enhanced by treatment with radio-chemotherapy. The transfer of pro-invasive cargos may yield important insights into the functional capacity of sEVs in invadopodia.