bluuebunny/crossref_metadata_2025_split huggingface dataset:
Changes in Distributed Motor Network Connectivity Correlates With Functional Outcome After Surgical Resection of Brain Tumors
Authors: Yamao Yukihiro , Sawamoto Nobukatsu , Kunieda Takeharu , Inano Rika , Shibata Sumiya , Kikuchi Takayuki , Arakawa Yoshiki , Yoshida Kazumichi , Matsumoto Riki , Ikeda Akio , Takahashi Ryosuke , Fukuyama Hidenao , Miyamoto Susumu 
Published: February 2023

BACKGROUND:
In patients with brain tumors around the motor cortices, deterioration of motor performance may be observed even if the integrity of the cortical output is maintained. Especially, resection of medial premotor area (PM) can cause postoperative deterioration called supplementary motor area syndrome.

OBJECTIVE:
To clarify the neuronal mechanisms underlying postsurgical deterioration with a case-control study.

METHODS:
Twelve patients with brain tumors underwent preoperative and postoperative sessions consisting of motor performance evaluation and 3T-magnetic resonance imaging data acquisition. Based on additional postsurgical motor deficits, 6 patients were classified into “deficit group,” and 6 others were into “no deficit group.” Using resting-state functional magnetic resonance imaging (fMRI), the integrity of functional connectivity was evaluated by placing a seed in the ipsilesional primary motor area (M1). With motor task fMRI, hand and foot representations were identified in the M1 and lateral and medial PMs. Probabilistic tractography assessed anatomic connectivity in the cortico-cortical and corticofugal networks.

RESULTS:
Functional connectivity among M1 and lateral and medial PMs during resting-state fMRI was reduced postoperatively in the deficit group (P < .05, corrected) and preserved in the no deficit group. The deficit was unlikely to be attributable to surgical resection of specific anatomic connectivity. The amplitude of motor-evoked potential was maintained in available cases. These intraoperative observations agree with imaging findings suggesting preserved anatomic connectivity of the estimated corticofugal pathway.

CONCLUSION:
The present findings suggest that supplementary motor area syndrome is caused by disorganization of functional connectivity among cortical motor networks rather than resection of anatomic connectivity of corticofugal pathway.
Controlling Excimer-Origin Circularly Polarized Luminescence of Bipyrenyl-Arginine Peptides by Cyclodextrin in Water
Authors: Imai Yoshitane , Mimura Yuki , Motomura Yuki , Ikemura Ryoya , Shizuma Motohiro , Kitamatsu Mizuki 
Published: February 2023

Abstract
It is important to optimize the photoexcited-state conformation of chiral luminescent molecules to enhance the intensity of circularly polarized luminescence (CPL) and control the direction of CPL rotation. In pyrenyl peptide luminophores, the intensity and sign of CPL is determined by the solvent and intramolecular distance between pyrenyl units in addition to peptide chirality. However, the control of CPL properties in water is difficult, and new methods to control CPL in water are required. In this study, we achieved amplification and control of the sign of excimer-origin CPL by adding γ-cyclodextrin to a flexible bipyrenyl peptide luminophore with two arginine groups in water.
Solving AC Optimal Power Flow with Discrete Decisions to Global Optimality
Authors: Aigner Kevin-Martin , Burlacu Robert , Liers Frauke , Martin Alexander 
Published: February 2023

We present a solution framework for general alternating current optimal power flow (AC OPF) problems that include discrete decisions. The latter occur, for instance, in the context of the curtailment of renewables or the switching of power-generation units and transmission lines. Our approach delivers globally optimal solutions and is provably convergent. We model AC OPF problems with discrete decisions as mixed-integer nonlinear programs (MINLPs). The solution method starts from a known framework that uses piecewise linear relaxations. These relaxations are modeled as mixed-integer linear programs and adaptively refined until some termination criterion is fulfilled. In this work, we extend and complement this approach by problem-specific as well as very general algorithmic enhancements. In particular, these are mixed-integer second order cone programs as well as primal and dual cutting planes. For example, objective and no-good cuts help to compute good feasible solutions in which outer approximation constraints tighten the relaxations. We present extensive numerical results for various AC OPF problems in which discrete decisions play a major role. Even for hard instances with a large proportion of discrete decisions, the method is able to generate high-quality solutions efficiently. Furthermore, we compare our approach with state-of-the-art MINLP solvers. Our method outperforms all other algorithms. History: Accepted by Andrea Lodi, Area Editor for Design & Analysis of Algorithms–Discrete. Funding: This research has been funded by the Federal Ministry of Education and Research of Germany [Grant 05M18WEB]. This research has been performed as part of the Energie Campus Nürnberg and is supported by funding of the Bavarian State Government. The authors thank the Deutsche Forschungsgemeinschaft for support within projects A05, B06, B07, and B10 of the Sonderforschungsbereich/Transregio 154 “Mathematical Modelling, Simulation and Optimization using the Example of Gas Networks.” This work has been supported by the Federal Ministry for Economic Affairs and Energy, Germany [Grant 03El1036A]. Supplemental Material: The online appendix is available at https://doi.org/10.1287/ijoc.2023.1270 .
Biologics for pediatric atopic dermatitis: A protocol of a systematic review and meta-analysis
Authors: Cao Rui , Lu Jiaxing , Chen Zhao 
Published: February 2023

Background
Atopic dermatitis is a chronic pruritic inflammatory skin disease commonly occurring in children. The objective of this study is to evaluate the treatment of pediatric atopic dermatitis with biologics, as they have displayed immense promising results in several recent clinical trials on atopic dermatitis (AD).

Methods
We will conduct an extensive search for RCTs in several databases, including Embase, Cochrane Library, Web of Science, and PubMed, from the inception of the study till 15th May 2022. The primary outcomes will be the proportion of patients with EASI 75/90/100 after 12–16 weeks of treatment. The secondary outcomes will include the Numerical Rating Scale (NRS), Investigator Global Assessment (IGA)0–1, body surface area (BSA), Dermatology Life Quality Index (DLQI) scores, and incidence of adverse reactions. All studies will be screened by two independent researchers. They will assess the risk of bias in the included studies according to the RCTs bias risk evaluation tool in Cochrane System Review Manual 5.1.0. Meta-analysis will be performed using RevMan V.5.3.0 software.

Results
The research results will provide a reference for the clinical application of biological agents in pediatric atopic dermatitis.

Conclusion
We aim to evaluate the efficacy and safety of biologics in pediatric atopic dermatitis cases and provide evidence-based data for easy clinical application.

PROSPERO registration number
CRD42022319052 (https://www.crd.york.ac.uk/PROSPERO/#joinuppage).
A large outbreak of COVID-19 linked to an end of term trip to Menorca (Spain) by secondary school students in summer 2021
Authors: Forcadell-Díez Lluís , Rius Cristina , Salobral Raúl , Sánchez-Valdivia Nacho , Mendioroz Jacobo , Godoy Pere , Badiella Jarque Elisabet , Ferrandiz-Mont David , Moreno Cervera Daniel , Jordan Suriñach Berta , Vilalta-Carrera Alba , Guadalupe-Fernández Víctor , Mateo Basilio Julia , Farràs Tapiol Sergi , Pérez Gloria 
Published: February 2023

Background
An outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) occurred in young people from Catalonia (Spain) who travelled to Menorca (Spain) in summer 2021. This outbreak appeared when governments relaxed Covid-19 preventive measures: the mask usage and the opening of nightlife. It was related to a super-disseminating mass event: Sant Joan festivities in Ciutadella. The aim of this article is to describe an outbreak of COVID-19 in young people aged 17–19 years from Catalonia travelling to Menorca.

Methods
This is an observational study of a COVID-19 outbreak. The study population comprised Catalonian youth aged 17–19 years who travelled to Menorca from 15 June to 10 July. Epidemiological descriptive indicators were obtained. Descriptive and geographical statistics were carried out. Bivariate Moran’s I test was used to identify spatial autocorrelation between the place of residence and deprivation. The outbreak control method was based on identifying and stopping chains of transmission by implementing the test-trace-isolate-quarantine (TTIQ) strategy.

Results
We identified 515 confirmed cases infected in Menorca, 296 (57.5%) in girls and 219 (42.5%) in boys, with a total of 2,280 close contacts. Of them, 245 (10.7%) were confirmed as cases. The cases were diagnosed between 15 June and 10 July. None of the persons with confirmed infection died or required hospitalisation. The attack rate was 27.2%. There was an inverse relationship between deprivation and number of confirmed cases (p<0.005), there were clusters of confirmed cases in the most socioeconomic favoured areas.

Discussion
The outbreak is related with young people from socioeconomic favoured areas who travelled to Menorca in summer 2021. Failure to comply with preventive measures in binge-drinking events and during holidays may have favoured SARS-CoV-2 transmission. The interauthority coordination and establishment of a clear line of leadership allowed continuous communication between institutions, which were key to managing this complex COVID-19 outbreak.
Design Characteristics for Sustainable Pediatric Healthcare Environments: Stakeholder’s Perception
Authors: Babbu Abdul Halim , Haque Mazharul 
Published: February 2023

Background: The therapeutic environments of children and adolescents differ from those of adults, and are complex entities. Though studies have been conducted on the built environments of adult healthcare facilities, the impact of therapeutic environments on the health outcomes of pediatric patients is yet to be explored. Objective: The purpose of this study is to investigate design characteristics for creating a pleasant, comfortable, and child-friendly physical environment in children's healthcare settings. Method: After extracting features that influence pediatric healthcare design from the relevant literature, a survey questionnaire, consisting of 45 items from 14 domains, was conducted. Principal component analysis (PCA) using varimax rotation was used to explore the intrinsic concept in an Indian sample (N= 224). Results: PCA with varimax rotation yielded 4- factors: (1) child-centred design characteristics; (2) indoor ambient environmental quality; (3) positive distraction strategies; and (4) sense of autonomy and control, accounting for 78.14% of the explained variance. A factor loading range of 0.41 to 0.93 was found across the four variables, indicating construct validity, and all the factors were found to be significantly related to each other. Conclusions: This study concludes that the built environment of pediatric healthcare settings impacts patients’ health outcomes and behaviour, with decreased patient stress & anxiety, and better family experience. The findings suggest the need of providing comfort to the children through several rejuvenating elements such as positive distraction strategies, play opportunities, family and peer interaction, child-friendly design, age-associated characteristics, etc. It also suggests various design characteristics that help contribute the positive patient health outcomes.
Keywords: pediatric therapeutic environment, healthcare design, child-friendly design, therapeutic play, family-centred care
Green Economy as a Prerequisite for Sustainable Development: Analysis of International and Ukrainian Experience
Authors: Bondarenko Valerii , Pokynchereda Vitalii , Pidvalna Oksana , Kolesnyk Tetiana , Sokoliuk Serhii 
Published: February 2023

Abstract
The article reflects the approaches to the essential content of the concept of green economy in the context of the implementation of ecologically-oriented production, ensuring the welfare of society and achieving sustainable development goals, the expediency and socio-economic need to transition to a system of management based on the principles of green economy concept, identifies priority activities to ensure an effective and progressive transition to sustainable development and green economy. The key challenges facing the global economy at the present stage are presented, and the possible options for an effective response to such problems through the prism of sustainable development and implementation of the principles of green economy are considered. The experience of countries of the European and Asia-Pacific regions in developing national strategies for transition to a green economy, which are based on ensuring the life of society in harmony with nature, the promotion of natural biodiversity and the growth of human well-being through the promotion of conservation, is analyzed. The organizational and legal aspects of the formation of green economy in Ukraine are considered, the problematic issues of implementation of the ideas and principles of the concept of green economy on the way to ensure progressive development are given. According to the approved strategy of the state ecological policy of Ukraine the directions of development of green economy, providing introduction of the effective financial tools, in particular, green bonds, green crediting, creation of funds of financing of green projects, optimization of green tariffs are offered and proved.
Key words: green economy, sustainable development, globalization, global challenges, rational economic management, social justice.
Working to Answer the Effectiveness of Nutrition in IBD: Still a Ways to Go
Authors: Otley Anthony , Grover Zubin , Moayyedi Paul 
Published: February 2023

Abstract
The Specific Carbohydrate diet (SCD) is an exclusion diet widely popular among patients with IBD, which restricts carbohydrates and processed foods. Two recently concluded controlled studies PRODUCE (Personalized Research on Diet in Ulcerative Colitis (UC) and Crohn's Disease) and DINE-CD (The Diet to Induce Remission in Crohn's disease) confirm efficacy of SCD on symptom control but fail to demonstrate a sustained anti-inflammatory response. These dietary studies are a welcome addition to a poorly understood field of dietary management of IBD, we explore some practical challenges including trial designs, recruitment, and retention in long term dietary intervention studies. Future dietary intervention studies should, therefore, incorporate endoscopic end points to establish a true anti-inflammatory response to elimination diets, preferably with detailed multi-omics analysis to understand mechanism of action.
Asymptomatic Hepatic Leiomyoma in an Immunocompetent Middle-Aged Woman
Authors: Nwankwo Eugene C. , Burton Samuel J. , Brotherton Tim , Carpenter Danielle , Qureshi Kamran 
Published: February 2023

ABSTRACT
Primary hepatic leiomyomas are rare tumors most commonly in immunosuppressed individuals who are coinfected with Epstein-Barr virus (EBV). From our literature review, there have been 50 published cases, of which 24 were immunocompetent individuals and only 5 were negative for EBV infection. We report a case of primary hepatic leiomyomas in an asymptomatic middle-aged woman without a history of immunosuppression or EBV infection.
Metastatic Bronchoalveolar Carcinoma Presenting as Chronic Esophageal Stricture
Authors: Alappan Harish R. , Gwan-Nulla Daniel , Rizzo Kathryn 
Published: February 2023

ABSTRACT
We report a case of chronic esophageal stricture resulting from metastatic bronchoalveolar carcinoma in a patient without a prior diagnosis of malignancy. The diagnosis was made on pathologic examination of the resected specimen after esophagectomy. Further workup subsequently revealed additional sites of metastasis.
Metastatic Hepatocellular Carcinoma Masquerading as Acute Diverticulitis
Authors: Brotherton Tim , Al-Taee Ahmad M. , Carpenter Danielle , Cheesman Antonio R. 
Published: February 2023

ABSTRACT
Colorectal cancer may masquerade as acute diverticulitis. Our case is a 71-year-old man who presented to the emergency department with abdominal pain and was diagnosed with acute diverticulitis. He was ultimately found to have metastatic hepatocellular carcinoma to the colon without any evidence of diverticular disease on colonoscopy. Although the most common malignancy to masquerade as diverticulitis is colorectal cancer, metastatic deposits should also be considered, especially in patients with a history of extracolonic malignancy.
An Unexpected Anemia Hiding a Rare Syndrome With Overlapping Phenotypes
Authors: Dal Buono Arianna , Poliani Laura , Repici Alessandro , Hassan Cesare , Bianchi Paolo 
Published: February 2023

ABSTRACT
Gastric polyposis is a rare endoscopic finding that can imply genetic syndromes predisposing to cancer development. Among the possible conditions associated with gastric polyposis and early onset gastric cancer (younger than 45 years) is juvenile polyposis syndrome. We present a clinical case of early onset gastric cancer associated with a frameshift mutation in the gene SMAD4. Individuals carrying a pathogenic variant of this gene have a high risk of malignant transformation, especially of gastric cancer. Moreover, most of these patients present also with extraintestinal features of the hereditary hemorrhagic telangiectasia, and the first symptom prompting medical evaluation is anemia.
Graft-vs-Host Disease in a Liver Transplant Patient With COVID-19 Infection
Authors: Kiparizoska Sara , Nguyen Veronica , Rangnekar Amol S. 
Published: February 2023

ABSTRACT
Graft-vs-host disease (GVHD) after liver transplant is a rare complication with high mortality outcomes. Because of the rarity of occurrence, there is no standardized consensus for treatment. Early recognition of symptoms and a multidisciplinary approach with input from transplant hepatology and hematology is important to determine a treatment plan and improve outcomes. We present a unique case of a 49-year-old woman who developed GVHD during a coronavirus disease 2019 (COVID-19) infection 3 months after receiving a liver transplant. More data are needed to determine whether COVID-19 infection itself correlates with a risk of developing GVHD.
Tradisi Rabu Wekasan dalam Persepsi Milenial
Authors: Fafi Masiroh  , Rikha Zulia  , Azkia Shofani Aulia  
Published: February 2023

The Rabu Wekasan tradition deal with islamic values because it was made from the assimilation of Javanese and Islamic cultures. The implementation of The Rabu Wekasan tradition gives pro and contra from various circles, this condition impend continuity of the tradition. The cultural action need to be carried out through society participation, especially millennials as the next generation of this country have to save the Rabu Wekasan traditions and rituals. The information about millennial perceptions of The Rabu Wekasan tradition is very important to explore as a reference about the next actions of them in continuity of The Rabu Wekasan tradition. This study aims to tell the history of The Rabu Wekasan tradition and to analyze the perceptions of the Semarang State University Faculty of Social Sciences students as millenials about The Rabu Wekasan tradition. This research was conducted through observation, interviews, questionnaires and literature study. Sources of data collected are reduced, analyzed then concluded. The results show that The Rabu Wekasan tradition have a beginning from the worship of the Javanese people which then developed into a tradition. This is supported by it name which comes from the Javanese language. Millennial perceptions of The Rabu Wekasan tradition are positive, based on 100 students, 91% said that The Rabu Wekasan tradition is important to take care of, 82% felt responsible for take care of, 75% answered that the tradition is useful because it is a local identity and rich in meaning of life.
[Tradisi Rabu Wekasan berkaitan erat dengan nilai-nilai Islam karena lahir dari asimilasi budaya Jawa dan Islam. Tradisi Rabu Wekasan dalam pelaksanaannya menuai pro dan kontra di berbagai kalangan, sehingga mengancam kelestarian tradisi tersebut. Gerakan kultural perlu dilakukan melalui andil masyarakat khususnya milenial sebagai penerus bangsa untuk menjaga tradisi dan ritualnya. Informasi terkait persepsi milenial terhadap Rabu Wekasan sangatlah penting untuk digali dalam rangka menjaga kelestarian tradisi tersebut, dan juga sebagai acuan untuk mengetahui tindakan milenial selanjutnya dalam melestarikan Rabu Wekasan. Penelitian ini bertujuan mengetahui sejarah Rabu Wekasan serta menganalisis persepsi mahasiswa Fakultas Ilmu Sosial (FIS) Universitas Negeri Semarang terhadap Rabu Wekasan. Penelitian dilakukan melalui observasi, wawancara, kuesioner dan studi pustaka. Sumber data yang terkumpul direduksi, dianalisis kemudian ditarik kesimpulan. Hasilnya didapatkan bahwa sejarah Rabu Wekasan berasal dari ibadah yang dilakukan masyarakat Jawa kemudian berkembang menjadi tradisi. Hal tersebut didukung dengan namannya yang berasal dari Bahasa Jawa. Persepsi milenial terhadap Rabu Wekasan merupakan persepsi positif, yang ditunjukkan dari 100 mahasiswa, 91% mengatakan bahwa Rabu Wekasan penting untuk dilestarikan, 82% merasa bertanggung jawab untuk melestarikan, 75% menjawab tradisi tersebut bermanfaat karena merupakan identitas lokal serta kaya akan pembelajaran dan makna hidup.]
Transplant Renal Vein Thrombosis Rescued in a Pediatric Patient Using Suction Thrombectomy
Authors: Batra Anjay , Pallister Zachary , Chung Jayer , Fuller Kelby , O'Mahony Christine , Galván N. Thao 
Published: February 2023

Abstract
Renal vein thrombosis after kidney transplant is a rare but potentially graft-threatening event. As sequelae of this complication can range from brief acute kidney injury to total graft failure, it is necessary to maintain close clinical observation postoperatively. If posttransplant renal vein thrombosis does occur, recanalization may be attempted with mechanical thrombectomy, suction thrombectomy, or explantation and reimplantation of the allograft. This is a novel report of the successful use of suction thrombectomy to treat renal vein thrombosis in a pediatric kidney transplant.
The Democratic Dangers of Central Bank Planning
Authors: Coombs Nathan 
Published: February 2023

Abstract
Eric Monnet makes the case that central banks should introduce welfare-oriented credit policies and suggests legitimating these new powers through the establishment of deliberative credit councils. In this article, I argue that Monnet fails to consider how his model of central bank planning might insulate rather than democratize central banking. With low trust in experts and no society-wide consensus about how best to respond to wicked problems such as climate change, the principal danger is that Monnet’s credit councils may allow political actors to pursue agendas they do not feel they can get past electorates. Indeed, political actors may see shaping central banks’ credit policies as preferable to engaging the contentious fiscal policy domain precisely because the effects of credit policies cannot be easily held to account by voters. I suggest that credit councils are unlikely to provide a democratic channel for redressing these problems because they will inevitably privilege the voices of experts from the financial sector, industry, and (non-)governmental organisations – a de facto epistocracy – over the lay publics subject to their decisions.