bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimal thermal conditions for corals extend poleward with oceanic warming
Authors: Landry Yuan Félix , Yamakita Takehisa , Bonebrake Timothy C. , McIlroy Shelby E. 
Published: August 2023

AbstractAimThe capacity for poleward range expansions beyond the tropics in corals hinges on ecophysiological constraints and resulting responses to climatic variability. We aimed to determine how future warming will affect coral habitat suitability at the poleward range edges of these foundational species in the Northwest Pacific.LocationNorthwest Pacific.MethodsWe generated models integrating thermal physiological constraints of corals adapted to extreme seasonality in Hong Kong, specifically the minimum annual temperature and the proportion of time annually spent at seasonal extremes. With these models, we projected habitat suitability for five coral species under current and future climatic conditions across the Northwest Pacific.ResultsClimate model projections reveal an easing of thermal constraints on the leading‐edge of coral ecophysiological limits with an expansion of thermally suitable habitat poleward by 2°–7° in latitude depending on the coral species and model considered. We also highlight a potential divergence of present and future thermal regimes that may lead to a mismatch in suitability for corals currently inhabiting high latitude reefs.Main ConclusionsUnderstanding the thermal constraints on coral distributions and defining the potential range of corals under climate change is critical for adaptive management that focuses on coral conservation and ensuring ecosystem function of existing subtropical and temperate ecosystems.
Cardiovascular efficacy and safety of antidiabetic agents: A network meta‐analysis of randomized controlled trials
Authors: Sohn Minji , Frias Juan P. , Lim Soo 
Published: August 2023

AbstractAimAn important characteristic of glucose‐lowering therapies (GLTs) is their ability to prevent cardiovascular complications. We aimed to investigate the cardiorenal efficacy and general safety of GLTs.Materials and MethodsMulticentre, randomized, clinical trials that included over 100 participants comparing antidiabetic agents with a placebo or a different antidiabetic agent and reporting major adverse cardiovascular events (MACEs), or primarily reporting heart failure, were searched in the PubMed, Embase and Cochrane databases. Data were extracted independently for random‐effects network meta‐analyses to calculate the hazard ratio estimates.ResultsForty‐three trials that compared nine types of GLTs were included in the present analysis. The risk of three‐point MACE was reduced in the presence of glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs), sodium‐glucose cotransporter‐2 inhibitors (SGLT‐2is) and thiazolidinedione therapy compared with the placebo, dipeptidyl peptidase‐4 inhibitors, or insulin therapy. GLP‐1 RAs were favourable for cardiovascular and renal outcomes. SGLT‐2is reduced renal outcomes by ~40%, which was superior to other GLTs. Thiazolidinedione therapy increased the risks of hospitalization for heart failure and had no benefits on mortality. Adverse events leading to drug discontinuation were higher with GLP‐1 RAs and thiazolidinediones than placebo.ConclusionsGLP‐1 RAs, SGLT‐2is and thiazolidinediones reduced three‐point MACE compared with other GLTs. Each drug class had unique advantages and disadvantages.
Sports injuries and game stakes: Concussions in the National Football League
Authors: Courty Pascal , Cisyk Jeffrey 
Published: August 2023

AbstractThe National Football League's regular‐season games are not of equal importance: some games loom larger than others for determining a team's chance to qualify for the playoffs. We develop an incentive‐based measure of the impact of winning a game on a team's qualification probability to study the relationship between stakes and injuries. We find teams are 24 percentage points more likely to suffer concussions in games where a win secures one team a playoff berth. This is the first evidence to support the risk‐escalation hypothesis that injuries increase with a competition's stakes. We then discuss implications for sports injury prevention.
Patients with PSA below 0.2 ng/mL at 8 years post high‐dose‐rate brachytherapy have an extremely low risk of subsequent recurrence
Authors: Nakazono Minoru , Urabe Fumihiko , Iwatani Kosuke , Imai Yu , Tashiro Kojiro , Honda Mariko , Koike Yusuke , Shimomura Tatsuya , Sato Shun , Takahashi Hiroyuki , Miki Kenta , Aoki Manabu , Kimura Takahiro 
Published: August 2023

ObjectivesWe have analyzed the long‐term follow‐up data of patients with prostate cancer (PCa) who underwent high‐dose‐rate brachytherapy (HDR–BT) and external beam radiotherapy (EBRT) combined with long‐term androgen deprivation therapy (ADT). The objective was to determine the optimal time for cessation of PSA monitoring after HDR–BT.MethodsWe included 309 patients with clinical stage T1c‐T4 N0–1 M0 PCa who received HDR‐BT and EBRT combined with long‐term ADT between 2005 and 2018. We stratified the patients based on their prostate‐specific antigen (PSA) levels and identified the factors associated with biochemical recurrence (BCR) and clinical progression (CP).ResultsThe median follow‐up duration was 98 months (range: 31–207 months). Among the 306 patients, 76 developed BCR and 47 developed CP subsequently. We found that the PSA levels at 3, 5, and 8 years significantly correlated with the oncological outcomes of brachytherapy. No patient with a PSA level ≤ 0.2 ng/mL at 8 years later developed BCR or CP.ConclusionOur long‐term data suggest that in the presence of a PSA level ≤ 0.2 ng/mL at 8 years later, PSA monitoring may be safely discontinued due to the extremely low risk of subsequent oncological events. The data presented in this study will assist clinicians in determining the optimal management strategy for patients with PCa following HDR–BT and EBRT combined with long‐term ADT.
Internet research of utilization of social media in patients with urological disease and their families in Japan
Authors: Wada Naoki , Takagi Haruka , Tekeuchi Keigo , Morishita Shun , Makino Shogo , Ohtani Miyu , Kobayashi Shin , Hori Jun‐ichi , Kitta Takeya , Kakizaki Hidehiro 
Published: August 2023

ObjectivesTo survey the utilization of social media (SoMe) in patients with urological disease and their families.MethodsAmong the panel members registered in NEO Marketing Inc. (Tokyo, Japan), 300 people who or whose families were visiting the urological department regularly were included. Study subjects were randomly chosen and surveyed using the questionnaire over the internet.ResultsThis study included 203 (68%) males and 97 (32%) females. The mean age was 62 (21–85) in males and 49 (22–75) in females. One hundred and ten subjects (37%) had no account for any SoMe. The account holders of YouTube, Twitter, Facebook, Instagram, and TikTok were 119 (40%), 117 (39%), 101 (34%), 90 (30%), and 33 (11%), respectively. The proportions of account holders were different depending on gender, age, and platforms. Frequent viewers on YouTube, Twitter, Facebook, Instagram, and TikTok were 100 (84%), 89 (76%), 63 (62%), 66 (73%), and 24 (73%), respectively. Of 190 who had accounts for any SoMes, 64 (34%) found any information about urological diseases of themselves or their families. Among the all subjects, 162 (54%) thought that they would like to view the medical contents on SoMes submitted by medical societies.ConclusionsPatients with urological disease and their families in Japan occasionally utilize SoMe to obtain information on their diseases and prefer professional medical information on SoMe. The gender and age of SoMe users and the optimal platform should be considered when posting medical information on SoMe.
Biogeographic barriers and historic climate shape the phylogeography and demography of the common gartersnake
Authors: Jones Leonard N. , Leaché Adam D. , Burbrink Frank T. 
Published: August 2023

AbstractAimCurrent distributions of widespread North American (NA) species have been shaped by Pleistocene glacial cycles, latitudinal temperature gradients, sharp longitudinal habitat transitions and the vicariant effects of major mountain and river systems that subdivide the continent. Within these transcontinental species, genetic diversity patterns might not conform to established biogeographic breaks compared to more spatially restricted taxa due to intrinsic differences or spatiotemporal differences. In this study, we highlight the effects of these extrinsic variables on genetic structuring by investigating the phylogeographic history of a widespread generalist squamate found throughout NA.LocationNorth America.TaxonCommon gartersnake, Thamnophis sirtalis.MethodsWe evaluate the effects of major river basins and the forest‐grassland transition into the Interior Plains on genetic structure patterns using phylogenetic, spatially informed population structure and demographic analyses of single nucleotide polymorphism data and address range expansion history with ecological niche modelling using locality and historic climate data.ResultsWe identify four phylogeographic lineages with varying degrees of connectivity between them. We find discordant population structure patterns between sex‐linked and autosomal loci with respect to the relationship between the central NA lineage relative to coastal lineages. We find support for southeast Pleistocene refugia where recent secondary contact occurred during the Last Glacial Maximum and evidence for both northern and southern refugia in western NA.Main ConclusionOur results provide strong evidence for a Pliocene origin for T. sirtalis in central‐southeastern NA preceding its rapid expansion across the continent prior to middle Pleistocene climate‐mediated lineage formation. We implicate major riverine networks within the Mississippi watershed in likely repeated westward expansion events across the Interior Plains. Finally, we corroborate prior conclusions that phenotypic differences between subspecies do not reflect shared evolutionary history and note that the degree of separation between inferred lineages warrants further investigation before any taxonomic revisions are proposed.
Parents' experiences with interprofessional collaboration in neonatal pain management: A descriptive qualitative study
Authors: Mäki‐Asiala Mariaana , Axelin Anna , Pölkki Tarja 
Published: August 2023

AbstractAimTo describe parents' experiences with interprofessional collaboration (IPC) in neonatal pain management.BackgroundNeonatal care should be based on IPC, and non‐pharmacological pain‐relieving methods are recommended to be used primarily that enables parental participation. However, there is a lack of knowledge about pain management on IPC from the parent's viewpoint.DesignA descriptive qualitative study.MethodThe research involved a purposive sample of parents (n = 16) whose infant had been treated at a neonatal intensive care unit in Finland. Interviews were conducted with participants from all over Finland who were recruited through the national association for premature infants. Parents discussed their experiences during semi‐structured interviews which were guided by the subareas of IPC, partnership, cooperation and coordination. The data were analysed using deductive‐inductive content analysis. The reporting of results followed COREQ guidelines.ResultsBased on the parent's experiences the partnership involved themes of understanding the neonatal pain management context, being able to influence the pain management, and feeling valued. Cooperation included themes of identifying different roles and equality. Coordination was described through the sharing of knowledge, skills and expertise, as well as feeling supported by professionals.ConclusionParental involvement on IPC should be developed through interventions that involve training around pain assessment and non‐pharmacological pain‐relief methods.Relevance for clinical practiceProfessionals involved in neonatal care should act in a goal‐oriented and unified manner to promote a culture of care that allows for active parental participation.No patient or public contributionThe research has been carried out in accordance with good scientific practice. Only the research team has been involved in the design, conduct, analysis and drafting of the manuscript.
A Study of the Conceptual Structure of Growth Mindsets and Their Impact on Self‐Improvement Motivation
Authors: Takehashi Hiroki , Toyosawa Junko , Shimai Satoshi , Yananose Maki 
Published: August 2023

AbstractThis study examined the conceptual structure and motivational effects of growth mindsets based on the perspective of character strengths. An internet survey was conducted with 1,000 workers (500 males and 500 females; age range 20–59 years, M = 40.1 years, SD = 10.7 years). Participants were presented with 25 strengths (i.e., intelligence and 24 character strengths) and were asked to rate their perceived competence, growth mindset, and improvement intention for each strength. The exploratory factor analyses on perceived competence, growth mindset, and improvement intention identified five common factors: wisdom, willpower, temperance, transcendence, and groupness. Moreover, regression analyses indicated that a growth mindset was more strongly related to improvement intention than perceived competence. Furthermore, regression analyses found domain‐specific effects of growth mindsets on improvement intention. Thus, the intention to improve a particular strength was more closely related to that particular growth mindset than to other growth mindsets. The theoretical and educational implications are aired in the discussion section.
Sustainability‐related transgressions in global supply chains: When do legitimacy spillovers hurt buying firms the most?
Authors: Mateska Ivana , Busse Christian , Kach Andrew P. , Wagner Stephan M. 
Published: August 2023

AbstractIn a globalized world, buying firms increasingly face criticism regarding sustainability‐related transgressions in their supply chains, yet scholarship concerning whether such negative press has any bottom‐line effects has only just begun emerging. This study develops and tests theory on the relationship between reported supplier sustainability incidents and the associated stock price impact for the buying firm. An event study comprising 1699 events related to 374 buying firms supports our hypothesis that media coverage of environmental, social, or governance‐related transgressions in the supply chain results in decreased market capitalization for the buying firm. A subsequent regression analysis indicates that the influence potential of information intermediaries, the country‐level sustainability risk of the supplier, and the industry‐level sustainability risk of the buying firm all affect the magnitude of the investors' reaction. Conversely, the severity of the incident does not predict the magnitude of the stock price reaction.
Species diversity and detection of pathogens in phlebotomine sand flies collected from forest management areas of Quintana Roo, Mexico
Authors: Martínez‐Burgos Maribel , Lozano‐Sardaneta Yokomi N. , Rodríguez‐Rojas Jorge J. , Gómez‐Rivera Ángel S. , Canto‐Mis Karla L. , Flores‐Escobar Eduardo , Mis‐Ávila Pedro C. , Correa‐Morales Fabián , Becker Ingeborg 
Published: August 2023

AbstractSand flies have expanded their areas of distribution, thereby increasing the risk of pathogen transmission in non‐endemic areas. To establish efficient prevention and control strategies for the transmission of vector‐borne pathogens, it is important to understand seasonal dynamics of their vectors. In Mexico, there are several areas where the contact between sand flies, hosts and reservoirs favours the transmission of the pathogen. We compared sand fly communities in a forest management area and a conserved area in Noh‐Bec, Quintana Roo, Mexico. The analysis included species diversity, activity peaks and molecular detection of pathogens. Sand flies were collected from November to December 2021 and April to May 2022, during 84 night‐traps. The conserved area showed higher numbers and greater species heterogeneity of sand flies as compared with the other sites. The β‐diversity analysis revealed that sites disturbed by logging (S1, S2, S3) had greater similarity (90%) in their sand fly species composition than a conserved area (S4) (similarity = 36%). Although none of the specimens were infected with Leishmania, we detected Wolbachia (19.4%) in all four sites, as well as Bartonella (3.25%) only in the disturbed sites. Further studies on the dynamics of sand fly populations and their association with pathogens are necessary.
Diversity and biogeography of plant phyllosphere bacteria are governed by latitude‐dependent mechanisms
Authors: Wang Zihui , Jiang Yuan , Zhang Minhua , Chu Chengjin , Chen Yongfa , Fang Shuai , Jin Guangze , Jiang Mingxi , Lian Ju‐Yu , Li Yanpeng , Liu Yu , Ma Keping , Mi Xiangcheng , Qiao Xiujuan , Wang Xihua , Wang Xugao , Xu Han , Ye Wanhui , Zhu Li , Zhu Yan , He Fangliang , Kembel Steven W. 
Published: August 2023

Summary

Predicting and managing the structure and function of plant microbiomes requires quantitative understanding of community assembly and predictive models of spatial distributions at broad geographic scales.

Here, we quantified the relative contribution of abiotic and biotic factors to the assembly of phyllosphere bacterial communities, and developed spatial distribution models for keystone bacterial taxa along a latitudinal gradient, by analyzing 16S rRNA gene sequences from 1453 leaf samples taken from 329 plant species in China.

We demonstrated a latitudinal gradient in phyllosphere bacterial diversity and community composition, which was mostly explained by climate and host plant factors. We found that host‐related factors were increasingly important in explaining bacterial assembly at higher latitudes while nonhost factors including abiotic environments, spatial proximity and plant neighbors were more important at lower latitudes. We further showed that local plant–bacteria associations were interconnected by hub bacteria taxa to form metacommunity‐level networks, and the spatial distribution of these hub taxa was controlled by hosts and spatial factors with varying importance across latitudes.

For the first time, we documented a latitude‐dependent importance in the driving factors of phyllosphere bacteria assembly and distribution, serving as a baseline for predicting future changes in plant phyllosphere microbiomes under global change and human activities.
The impact of import competition from China on firm‐level productivity growth in the European Union*
Authors: Friesenbichler Klaus S. , Kügler Agnes , Reinstaller Andreas 
Published: August 2023

AbstractWe re‐examined the impact of rising imports from China on intra‐firm productivity growth in the European Union during the period 2005–16. In contrast to previous studies, we found that an increasing share of Chinese imports in total imports has slowed productivity growth over the observation period. This unfolded especially after the 2008/09 financial crisis and was more pronounced for firms with lower productivity growth. On average, the net effect of China's increasing import intensity on productivity growth has been negative for firms in the European Union since 2010. At the beginning of the sample, firms growing at the median rate experienced a modest growth‐enhancing effect of 0.02 percentage points, which turned slightly negative at −0.06 percentage points in the last observation year. The effect was muted for high‐growth multinational firms, which experienced a productivity growth premium from Chinese import competition at higher growth rates. Compared with the United States, the negative impact of Chinese import competition on the performance of EU firms is visible with a time lag.
REGULATOR OF FLOWERING AND STRESS manipulates stomatal density and size in Brachypodium
Authors: Ying Sheng , Scheible Wolf‐Rüdiger 
Published: August 2023

AbstractStomata are crucial for gas exchange and water evaporation, and environmental stimuli influence their density (SD) and size (SS). Although genes and mechanisms underlying stomatal development have been elucidated, stress‐responsive regulators of SD and SS are less well‐known. Previous studies have shown that the stress‐inducible Brachypodium RFS (REGULATOR OF FLOWERING AND STRESS, BdRFS) gene affects heading time and enhances drought tolerance by reducing leaf water loss. Here, we report that overexpression lines (OXs) of BdRFS have reduced SD and increased SS, regardless of soil water status. Furthermore, biomass and plant water content of OXs were significantly increased compared to wild type. CRISPR/Cas9‐mediated BdRFS knockout mutant (KO) exhibited the opposite stomatal characteristics and biomass changes. Reverse transcription‐quantitative polymerase chain reaction analysis revealed that expression of BdICE1 was reversely altered in OXs and KO, pointing to a potential cause for the observed changes in stomatal phenotypes. Stomatal and transcriptional changes were not observed in the Arabidopsis rfs double mutant. Taken together, RFS is a novel regulator of SD and SS and is a promising candidate for genetic engineering of climate‐resilient crops.
Relationship between sarcopenic obesity and cognitive function in patients with mild to moderate Alzheimer's disease
Authors: Weng Xiao‐fen , Liu Shan‐wen , Li Meng , Zhang Yu , Zhang Ying‐chun , Liu Chun‐feng , Zhu Jiang‐tao , Hu Hua 
Published: August 2023

BackgroundPrevious research has linked sarcopenic obesity (SO) to cognitive function; however, the relationship between cognitive performance and SO Alzheimer's disease (AD) patients remains unclear. This study aimed to investigate their relationship in AD patients.MethodsOne hundred and twenty mild to moderate AD patients and 56 normal controls were recruited. According to sarcopenia or obesity status, AD patients were classified into subgroups: normal, obesity, sarcopenia, and SO. Body composition, demographics, and sarcopenia parameters were assessed. Cognitive performance was evaluated using neuropsychological scales.ResultsAmong the 176 participants, the prevalence of SO in the moderate AD group was higher than in the normal control group. The moderate AD group had the lowest appendicular skeletal muscle mass index (ASMI) and the highest percentage of body fat (PBF). Hypertension and diabetes were more prevalent in the SO group than in the normal group among the subgroups. The sarcopenia and SO groups exhibited worse global cognitive function compared to the normal and obesity groups. Partial correlation analysis revealed that ASMI, PBF, and visceral fat area were associated with multiple cognitive domains scores. In logistic regression analysis, after adjusting for confounders, obesity was not found to be associated with AD. However, sarcopenia (odds ratio (OR) = 5.35, 95% CI: 1.27–22.46) and SO (OR = 5.84, 95% CI: 1.26–27.11) were identified as independent risk factors for AD.ConclusionsSO was associated with cognitive dysfunction in AD patients. Moreover, the impact of SO on cognitive decline was greater than that of sarcopenia. Early identification and intervention for SO may have a positive effect on the occurrence and progression of AD.