bluuebunny/crossref_metadata_2025_split huggingface dataset:
StereoselectiveC‐Aryl Glycosylation by Catalytic Cross‐Coupling of Heteroaryl Glycosyl Sulfones
Authors: Wang Quanquan , Lee Boon Chong , Song NingXi , Koh Ming Joo 
Published: March 2023

AbstractStereoselectiveC‐glycosylation reactions are increasingly gaining attention in carbohydrate chemistry because they enable glycosyl precursors, readily accessible as anomeric mixtures, to converge to a single diastereomeric product. However, controlling the stereochemical outcome through transition‐metal catalysis remains challenging, and methods that leverage bench‐stable heteroaryl glycosyl sulfone donors to facilitate glycosylation are rare. Herein, we show two complementary nonprecious metal catalytic systems, based on iron or nickel, which are capable of promoting efficient C−C coupling between heteroaryl glycosyl sulfones and aromatic nucleophiles or electrophiles through distinct mechanisms and modes of activation. DiverseC‐aryl glycosides were secured with excellent selectivity, scope, and functional‐group compatibility, and reliable access to both α and β isomers was possible for key sugar residues.
Study of Intermolecular Reconfiguration of Flexible COF‐5 Film and Its Ultra‐high Chemiresistive Humidity Sensitivity
Authors: Mei Aohan , Chen Wen , Yang Zifan , Zhou Min , Jin Wei , Yang Shuang , Chen Keqiang , Liu Yueli 
Published: March 2023

AbstractRecently, abundant active materials are developed to achieve the wearable detection of human body humidity. However, the limited response signal and sensitivity restrict further application due to their moderate affinity to water. Herein, we propose a flexible COF‐5 film synthesized by a brief vapor‐assisted method at room temperature. Intermediates are calculated by DFT simulation to investigate the interaction between COF‐5 and water. The adsorption and desorption of water molecule result in a reversible deformation of COF layers while creating new conductive path by π–π stacking. The as‐prepared COF‐5 films are applied to the flexible humidity sensors, exhibiting a resistance change in 4 orders of magnitude with remarkable linear relation between log function of resistance and relative humidity (RH) in 11 %–98 % RH range. Applications including respiratory monitoring and non‐contact switch are tested, providing a promising prospect for the detection of human body humidity.
Sulfonyl‐PYBOX Ligands Enable Kinetic Resolution of α‐Tertiary Azides by CuAAC
Authors: Gong Yi , Wang Cai , Zhou Feng , Liao Kui , Wang Xi‐Yu , Sun Ying , Zhang Yan‐Xue , Tu Zhi , Wang Xin , Zhou Jian 
Published: March 2023

AbstractWe report the first highly selective kinetic resolution of racemic α‐chiral azides via Cu‐catalyzed azide‐alkyne cycloaddition (CuAAC). Newly developed pyridine‐bisoxazoline (PYBOX) ligands, bearing a C4 sulfonyl group, enable effective kinetic resolution of racemic azides derived from privileged scaffolds such as indanone, cyclopentenone, and oxindole, and their asymmetric CuAAC to afford α‐tertiary 1,2,3‐triazoles with high to excellent ee values. DFT calculations and control experiments reveal that the C4 sulfonyl group decreases the Lewis basicity of the ligand and increases the electrophilicity of the copper center for better recognition of azides, and functions as a shielding group to make the chiral pocket of the catalyst more effective.
Rationally Modulating the Functions of Ni3Sn2‐NiSnOx Nanocomposite Electrocatalysts towards Enhanced Hydrogen Evolution Reaction
Authors: Wang Xiaomei , Long Guifa , Liu Bo , Li Zelong , Gao Wensheng , Zhang Pengfei , Zhang Hong , Zhou Xia , Duan Ruizhi , Hu Wei , Li Can 
Published: March 2023

AbstractIdentifying electrocatalysts with functions of easy dissociation of water, rapid transformation of hydroxyl and facile hydrogen‐hydrogen bond formation are indispensable while challenge for realizing efficient alkaline hydrogen evolution reaction (HER). Herein, we presented the design of Ni3Sn2‐NiSnOx nanocomposites towards addressing this challenge. We showed that Ni3Sn2 possessed ideal hydrogen adsorption and low hydroxyl adsorption abilities and NiSnOx facilitated water dissociation and hydroxyl transfer process, respectively. Consequently, the fine‐tuned interplay of the two functional parts realized the mutual coordination among the multiple functions and led to significantly boosted HER kinetics. Current densities of 10 and 1000 mA cm−2 were obtained at overpotentials of 14 and 165 mV on the optimized catalyst. This work highlights the significance of considering intrinsic interactions between active sites and all pertinent intermediates on obtaining promising electrocatalysts.
Superior anti‐smudge and flame retardancy of polydimethylsiloxane composite coating with phosphorus modified CO0.5Ni0.5Fe2O4
Authors: Yang Lei , Chen Yuese , Zhang Ting , Fu Heqing 
Published: March 2023

AbstractIn this work, the CO0.5Ni0.5Fe2O4 nanoparticles modified by phosphoric acid and NCO groups were prepared as flame‐retardants and cross‐linking centers. After modification, the dispersibility and flame‐retardant properties of the nanoparticles were effectively improved. On this basis, a kind of two‐component polyester‐based anti‐smudge and flame retardant hybrid coating in situ polymerization was prepared by using dihydroxy mono‐terminated PDMS to provide low surface energy, dipentaerythritol (Di‐PE) as a charring agent to provide sufficient cross‐linking sites. Water, ink, pump oil, and cooking oil could slide off the coated surface without leaving any traces. These novel hybrid coatings exhibit excellent anti‐graffiti properties and corrosion resistance even with 2 wt% PDMS and 3 wt% modified nanoparticles content. Moreover, Si, P, and CO0.5Ni0.5Fe2O4 all resulted in the formation of a char protective layer during burning. The thermal properties and flame retardant properties of the hybrid coatings were significantly improved. The peak heat release rate (PHRR) curves and the smoke production rate (PSPR) of hybrid coatings (3 wt% modified CO0.5Ni0.5Fe2O4) decreased by 44.2%, 55.7%, respectively, compared with pure composites. Besides, the hybrid coatings can be applied to a variety of substrates, including glass, steel, and fabric.
Stones, stories and ceremonies: A Gamilaraay, Arrernte, Luritja, Pitjantatjarra, Yankuntjatjarra perspective
Authors: Brennan Wayne , Wickman Sam Jupparula 
Published: March 2023

ABSTRACTCylcons are common in Australia, reported in early accounts (e.g., by Etheridge, McCarthy) as spiritually important for Aboriginal people, but where are the Indigenous perspectives on these important stones? Here we provide two stories about our engagement with these objects and then look at an archaeological excavation that allowed culture and science to come together helping us to interpret these stones.
Circular RNA hsa_circ_0000690 as a potential biomarker for diagnosis and prognosis of intracranial aneurysm: Closely relating to the volume of hemorrhage
Authors: Huang Yanming , Cao Huimin , Qi Xiaolong , Guan Celin , Que Shuanglin 
Published: March 2023

AbstractPurposeThis study aimed to explore circular RNA (circRNA) hsa_circ_0000690 as a potential biomarker for diagnosis and prognosis of intracranial aneurysm (IA) and its relationship with clinical factors and complications of IA.Material/methods216 IA patients admitted to the neurosurgery department of our hospital from January 2019 to December 2020 were selected as the experimental group, and 186 healthy volunteers were selected as the control group. The expression of hsa_circ_0000690 in peripheral blood was detected by quantitative real‐time PCR, and its diagnostic value was assessed by receiver operating characteristic curve. Relationship between hsa_circ_0000690 and clinical factors of IA was assessed by chi‐square test. Nonparametric test was used in univariate analysis, and regression analysis was used in multivariate analysis. Multivariate Cox proportional hazards regression analysis was used to analyze the survival time.ResultsCircRNA hsa_circ_0000690 of IA patients was relatively lower than that in the control group (p < .001). The AUC of hsa_circ_0000690 was 0.752, the specificity was 0.780, and sensitivity was 0.620, with diagnostic threshold of 0.0449. In addition, hsa_circ_0000690 expression was correlated with Glasgow Coma Scale, the volume of subarachnoid hemorrhage, modified Fisher scale, Hunt–Hess levels and surgical type. For hydrocephalus and delayed cerebral ischemia, hsa_circ_0000690 was significant in univariate analysis, but nonsignificant in multivariate analysis. For prognosis, hsa_circ_0000690 was significantly associated with modified Rankin Scales after surgery for 3 months, but not associated with survival time.ConclusionsThe expression of hsa_circ_0000690 can act as a diagnostic marker for IA and predict the prognosis of 3 months after operation and is closely related to the volume of hemorrhage.
Environmental, social, and governance risks and environmentally sensitive competitive strategies: A case study of a multinational logistics company
Authors: Gündoğdu Hakan Gökhan , Aytekin Ahmet , Toptancı Şura , Korucuk Selçuk , Karamaşa Çağlar 
Published: March 2023

AbstractGlobal climate change continues to have a negative impact on many sectors, particularly supply chains and logistics. Companies are progressively incorporating environmentally friendly practices into their strategies to tackle this global problem. Accordingly, the increase in environmental, social, and governance (ESG) risks has increased the importance of sustainable corporate governance. As a result, companies tend to place more emphasis on ESG initiatives. The study aims to analyze the importance levels of ESG criteria and to select the most ideal environmentally sensitive competitive strategy for multinational logistics companies. For this purpose, a set of criteria and alternatives for the businesses in the context of the related problem was defined, and a decision model was proposed to handle problems, which include uncertain information. In this context, q‐rung orthopair fuzzy (q‐ROF) weighted average technique was used for weighting the criteria and q‐ROF‐evaluation based on distance from average solution (q‐ROF‐EDAS) method was utilized for prioritizing the strategies. As a result, “greenhouse gas emissions” was identified as the most important criterion, while “eco‐efficiency” was selected as the best option for environmentally conscious competitive strategies.
Anatomical proposal for hyaluronic acid filler injection in subzygomatic arch depression: A dual‐plane injection technique
Authors: Yi Kyu‐Ho , Oh Wook , Kim Hyoung Moon , Ahn Hyo‐Sang , Hu Hyewon , Kim Hee‐Jin 
Published: March 2023

AbstractA subzygomatic arch depression creates a bulky face outline. To smoothen these depressions and correct facial contours, hyaluronic acid filler injection methods are frequently used. However, the complexity of the subzygomatic region make it difficult for practitioners to effectively volume the region. The conventional injection of single layer injection has limitations of lack in volume addition and unwanted undulations and spreading. The anatomical factors were reviewed with ultrasonography, three‐dimensional photogrammetric analysis, and cadaver dissection. In this anatomical study, the present knowledge on localizing filler injection with a more precisely demarcated dual‐plane injection was suggested. This study presents novel anatomical findings related to the injection of hyaluronic acid filler injection in the subzygomatic arch depression.
The role of viruses in cancer development versus cancer therapy: An oncological perspective
Authors: Javid Hossein , Sharbaf Mashhad Alireza , Yazdani Shaghayegh , Akbari Oryani Mahsa , Akbari Sanaz , Rezagholinejad Nastaran , Tajaldini Mahboubeh , Karimi‐Shahri Mehdi 
Published: March 2023

AbstractDespite great medical advances, oncological research is still looking for novel therapeutic approaches due to the limitation of conventional therapeutic agents. Virotherapy is one of these new emerging therapeutic approaches that attract attention with their widespread applications. Virotherapy use lives oncolytic viruses or genetically engineered viruses that selectively infect the tumor cells, replicate, and disrupt the cancerous cells that also induce their anticancer activity by stimulating the host antitumor immune response. Moreover, viruses are widely used as target delivery vectors for specifically delivering different genes, therapeutic agents, and immune‐stimulating agents. In addition to having antitumor activity by themselves in combination with conventional therapeutic agents like immune therapy and chemotherapy, Virotherapy agents also elicit promising outcomes. Therefore, in addition to their promising result in monotherapy use, virotherapy agents can also be used in combination with conventional cancer therapy, epigenetic modulators, and even microRNAs without any cross‐resistance, which allows the patient not to be deprived of her routine medicine. Still, this combination therapy reduces the adverse effect of the conventional therapies. All together suggest that virotherapy agents as novel potential agents in the field of cancer therapy.
Clinical implications and molecular features of tertiary lymphoid structures in stage I lung adenocarcinoma
Authors: Xu Xuejun , Gao Yifeng , Duan Shanzhou , Ding Qifeng , Wang Xiaofan , Dai Xiaoxiao , Zhang Yongsheng , Chen Yongbing , Chen Donglai 
Published: March 2023

AbstractAimsWe investigated the clinical implications and molecular features of TLS in stage I lung adenocarcinoma (LUAD).MethodsWe retrospectively reviewed the clinicopathological characteristics of 540 patients with p‐stage I LUAD. Logistic regression analysis was applied to determining the relationships between clinicopathological features and the presence of TLS. TLS‐associated immune infiltration pattern and signature genes were characterized using the transcriptomic profiles of 511 LUADs from The Cancer Genome Atlas (TCGA) database.ResultsThe presence of TLS was associated with a higher pT stage, low‐ and middle‐grade patterns, and the absence of tumor spreading through air spaces (STAS) and subsolid nodules. Multivariate Cox regression analysis identified that the presence of TLS was associated with favorable overall survival (OS) (p < 0.001) and recurrence‐free survival (RFS) (p < 0.001). Subgroup analysis showed that the most favorable OS (p < 0.001) and RFS (p < 0.001) favored the TLS + PD‐1‐ subgroup. The presence of TLS was characterized by abundance in antitumor immunocytes including activated CD8+ T and B cells as well as dentritic cells in TCGA cohort.ConclusionThe presence of TLS was an independent favorable factor for patients with stage I LUAD. The presence TLS was featured by special immune profiles which might aid oncologists in determining personalized adjuvant treatment.
The impact of dialectical behaviour therapy training on therapists in Singapore: A mixed‐methods study
Authors: Tan Michelle Yan Ling , Saw Young Ern , Keng Shian‐Ling , Lim Denise Su Hui 
Published: March 2023

AbstractBackgroundWhile dialectical behaviour therapy (DBT) has much empirical support for treating borderline personality disorder (BPD) and other conditions, little research has examined the dissemination of DBT in Southeast Asia.AimsThis study evaluated training outcomes following a 5‐day intensive DBT training programme in a group of psychologists in Singapore, who were in the process of implementing DBT as part of the training's objectives.MethodologyA mixed‐methods design was employed. Fourteen psychologists from a public psychiatric hospital in Singapore were recruited. Seven self‐selected into DBT training, and the remaining were matched controls who were not attending the training programme. The latter served as a nonrandomised control group. Prior to and 3 months after training, all participants completed measures of stigma towards BPD patients, burnout and therapeutic alliance. DBT training participants additionally attended a focus group discussion assessing their experiences and challenges implementing DBT in Singapore's context.FindingsQuantitative analyses using mixed ANOVA showed that, compared with controls, DBT‐trained participants demonstrated significantly greater increases in acceptance towards BPD patients. No between‐group differences were found on changes in burnout or therapy alliance with patients. Analyses of qualitative data using thematic analysis revealed that DBT training impacted the way participants conceptualised and delivered therapy for BPD patients, and highlighted several challenges in implementing DBT in the local hospital context.ConclusionThe findings demonstrate the potential of DBT training in improving clinicians' attitudes towards BPD patients and support a need for policymakers to prepare organisations for DBT implementation to ensure programme sustainability.
Three‐year clinical outcomes of the novel sirolimus‐eluting bioresorbable scaffold for the treatment of de novo coronary artery disease: A prospective patient‐level pooled analysis of NeoVas trials
Authors: Wang Xiaozeng , Li Yang , Fu Guosheng , Xu Bo , Zhou Yujie , Su Xi , Liu Huiliang , Zhang Zheng , Yu Bo , Tao Ling , Zheng Qun , Li Lang , Xu Kai , Han Yaling ,   the NeoVas OPC Investigators
Published: March 2023

AbstractObjectivesWe aimed to evaluate the long‐term outcomes of the novel NeoVas sirolimus‐eluting bioresorbable scaffold (BRS) for the treatment of de novo coronary artery disease.BackgroundThe long‐term safety and efficacy of the novel NeoVas BRS are still needed to be elucidated.MethodsA total of 1103 patients with de novo native coronary lesions for coronary stenting were enrolled. The primary endpoint of target lesion failure (TLF) was defined as a composite of cardiac death (CD), target vessel myocardial infarction (TV‐MI), or ischemia‐driven‐target lesion revascularization (ID‐TLR).ResultsA three‐year clinical follow‐up period was available for 1,091 (98.9%) patients. The cumulative TLF rate was 7.2% with 0.8% for CD, 2.6% for TV‐MI, and 5.1% for ID‐TLR. Additionally, 128 (11.8%) patient‐oriented composite endpoint and 11 definite/probable stent thromboses (1.0%) were recorded.ConclusionsThe extended outcomes of the NeoVas objective performance criterion trial demonstrated a promising 3‐year efficacy and safety of the NeoVas BRS in low‐risk patients with low complexity in terms of lesions and comorbidities.
Organocatalytic Assembly Based on Aromatic Donor–Acceptor Interactions for the Asymmetric Aldol Reaction on Water
Authors: Meso Garrett , Gregorich David , Waite Aya Jane , Smith Sam , Liu Linang , Cortez Jacob , Harris Ender , Baluyut Rev Derek , Correa Natalia , Liang Jian , Liu Yu 
Published: March 2023

AbstractAromatic donor modified prolinamide and aromatic acceptor modified thiourea were synthesized. They self‐assembled into a cooperative organocatalytic system through the aromatic donor‐acceptor interaction and catalyzed aldol reactions in high yields and stereoselectivity on water. The aromatic donor‐acceptor interaction was confirmed by mass spectrum, UV‐vis titraition and 1H‐NMR titration experiments.
Modeling of Solar Photocatalytic Degradation of Rhodamine B Dye by TiO2 Nanoparticles Using an Artificial Neural Network
Authors: Reddy P. Swapna , Das Susmita 
Published: March 2023

AbstractAn artificial neural network (ANN) model was developed for the photocatalytic degradation of rhodamine B by TiO2 nanoparticles synthesized by the electrochemical method, under direct sunlight irradiation. The four inputs are: irradiation time, initial dye concentration, pH of the initial solution, and catalyst loading. The ANN model with 20 hidden neurons and with R2 of 0.999 shows minimum values of the performance metrics of 0.169, 2.020, 1.531, and 0.215 for the mean square error, the root mean square error, the mean absolute error, and the mean absolute percentage error, respectively. The optimized ANN configuration of 4‐20‐1 shows a good fit with the experimental data. The result shows that the sunlight irradiation time has the main impact on rhodamine B degradation at ∼55 %.
Taming the Lewis Superacid Al(ORF)3 (RF=C(CF3)3): DFT Guided Identification of the “Stable yet Reactive” Adduct SiPr2→Al(ORF)3; Its Use as ORF‐ Abstractor from a “Ni‐ORF” complex
Authors: Petit Julien , Babinot Julien , Saffon‐Merceron Nathalie , Magna Lionel , Mézailles Nicolas 
Published: March 2023

AbstractA DFT study of several L→Al(ORF)3 (L=Lewis bases) adducts allowed the identification of (iPr2S)→Al(ORF)3 1‐SiPr2 as a “stable yet reactive” adduct. 1‐SiPr2 was shown to act as a masked Lewis superacid able to release Al(ORF)3 under mild conditions. It could be used to abstract a ORF− ligand from (bipyMe2)Ni(ORF)2 (bipyMe2 : 6,6’‐dimethyl‐2,2’‐dipyridyl) and generate the nickel alkoxide complex [(bipyMe2)Ni(ORF)(iPr2S)]+[(RFO)3Al−F−Al(ORF)3]− 5. Ligand exchange of iPr2S by Ph3P yielded [(bipyMe2)Ni(ORF)(PPh3)]+[(RFO)3Al−F−Al(ORF)3]− 6.
Regulation of the Oxidase Mimetic Activity of Ceria Nanoparticles by Buffer Composition
Authors: Wu Yonghui , Yang Lu , Wu Qianqian , Liu Qingshan , Zou Ling , Yang Xiaochao , Tang Keyong 
Published: March 2023

AbstractCeria nanoparticles (CNPs) are important typical nanozymes with multiple enzyme mimetic activities, which could facilitate the oxidation of organic dyes in acidic conditions, because of the oxidase mimetic activity. Usually, the regulation of oxidase mimetic activity is focused on the adjustment of the structure, morphology, composition, surface, and other factors of nanozymes. However, the influence of the surrounding environment is not considered, which is very important during the reaction process. In this work, the oxidase mimetic activity of CNPs in buffer solutions including citric acid, acetic acid and glycine buffer solutions was investigated, with the results that carboxyl group in buffer solution could adsorb the CNPs on the surface to promote the oxidase mimetic activity. Due to the chelation with the cerium ion, the enhancement is more significant by molecules with polycarboxylic groups, and the enhancement is more efficient by carboxyl molecules in buffer solution, compared with the modification of the carboxyl groups on the surface, because of easier operation and smaller steric hindrance. From the viewpoint of increasing the oxidase mimetic activity of CNPs, the work is expected to provide references for the selection of the reaction systems to optimize the oxidase mimetic activity in bio‐detection applications.
Studies on Structural Changes of Modified MWCNTs: Material for Electrochemical Monitoring of Antiviral Drug in Human Serum Samples
Authors: Kaur Randeep , Bhardwaj Geetika , Singh Narinder , Kaur Navneet 
Published: March 2023

AbstractThe development of a universal approach for precisely tuning the electrochemical characteristics of conducting carbon nanotubes for tracking harmful agents in the human body with high selectivity and sensitivity remains a challenge. Herein, we describe a simplistic, versatile, and general approach to the construction of functionalized electrochemical material. The design of electrochemical material consists of (i) modification of multiwalled carbon nanotubes (MWCNT) with dipodal naphthyl‐based dipodal urea (KR‐1) through non‐covalent functionalization (KR‐1@MWCNT) which enhances the dispersibility of MWCNT and hence conductivity, (ii) complexation of KR‐1@MWCNT with Hg2+ accelerate the electron transfer in the material which amplify the detection response of functionalized material (i. e., Hg/KR‐1@MWCNT) towards various thymidine analogues. Further, the application of functionalized electrochemical material (Hg/KR‐1@MWCNT) achieves real‐time electrochemical monitoring of harmful antiviral drug 5‐iodo‐2’‐iododeoxyuridine (IUdR) levels in human serum for the first time.