bluuebunny/crossref_metadata_2025_split huggingface dataset:
Necessity of artificial intelligence techniques for power quality issues in electric vehicles
Authors: Kuruvilla Vidhya , Kumar Pandiyan Venkatesh 
Published: September 2023

<p>World transportation is in an electrified mass transitional phase due to the predominant features such as a greener environment, fewer maintenance requirements, improved reliability and energy management efficiency compared to conventional transportation. Numerous difficulties have emerged since electric vehicle sales hit record highs, including how electrified transportation works with the grid. Emerging innovations and technological advances in the field of artificial intelligence have led to the development of enhanced controllers for electric vehicle penetration with the grid. This work includes information on the integration of artificial intelligence strategies used for the mitigation of power quality issues. By merging artificial intelligence techniques into the grid, users can achieve efficient energy use and beneficial power interactions between the grid and electric vehicles. To assess the network's practicality, this research develops a charging model that uses a Tasmanian Devil optimization (TDO) algorithm based on MATLAB software. According to research, TDO improves the waveform quality by reducing the THD with better performance and achieves efficient power transfer between the grid and EVs.</p>
Development and Phenotype of Heart Failure in Long‐Term Survivors of Childhood Cancer: The CVSS Study
Authors: Göbel Sebastian , Wingerter Arthur , Prochaska Jürgen H. , Schulz Andreas , Neu Marie A. , Henninger Nicole , Spix Claudia , Beutel Manfred , Lackner Karl , Münzel Thomas , Lam Carolyn S. , Merzenich Hiltrud , Faber Jörg , Wild Philipp S. 
Published: September 2023

Background
The CVSS (Cardiac and Vascular Late Sequelae in Long‐Term Survivors of Childhood Cancer) study aimed to investigate the prevalence of different stages of heart failure (HF) in childhood cancer survivors (CCSs) compared with the general population.

Methods and Results

A total of 1002 CCSs (age range, 23–48 years) diagnosed with neoplasia before an age of 15 years underwent a comprehensive cardiovascular screening. An age‐ and sex‐matched sample from the population‐based GHS (Gutenberg Health Study) served as a comparison group. Although prevalence of HF was significantly higher in CCSs, prevalence of different HF stages varied strongly by specific tumor history. Compared with the population, the prevalence ratio was 2.6 (95% CI, 2.4–2.8) for HF stage A and 4.6 (95% CI, 4.1–5.1) for the composite of HF stage B to D in an age‐ and sex‐adjusted Poisson regression model. Multivariable linear regression, adjusting for tumor entities, age, sex, and cardiovascular risk factors, revealed a lower left ventricular ejection fraction in patients with history of bone tumors (
β,
−4.30 [95% CI, −5.70 to −2.80]), soft tissue sarcoma (
β,
−1.60 [95% CI, −2.90 to −0.30]), and renal tumors (
β,
−1.60 [95% CI, −2.80 to −0.29]) compared with the population. The same model for the diastolic marker, ratio of the peak early diastolic filling velocity/lateral mitral annular early diastolic velocity, showed an association only with cardiovascular risk factors but not with tumor entities.

Conclusions
The prevalence of HF stage A to D was significantly higher among long‐term CCSs compared with the population and varied strongly by tumor entity. Systolic dysfunction was primarily associated with tumor entities, whereas diastolic dysfunction was associated with a higher burden of cardiovascular risk factors in CCSs.
Leben im Verborgenen
Authors: Varga Simon 
Published: September 2023

Abstract
This article focusses on an examination of Epicurus’ understanding of self-sufficiency, which is only marginally addressed within research. But many traditions suggest paying more attention to the concept of self-sufficiency. The scarcity of available sources must be regarded as problematic; therefore here an attempt is made to reconstruct this concept. The thesis is that Epicurus discusses human striving for self-sufficiency in two different ways and thus more comprehensively than previously assumed: extrinsic (physical or external autarky) and intrinsic (psychic or internal autarky). As so often, Epicurus is not talking about a theory, but about an immediate practice: human striving for self-sufficiency, an indispensable prerequisite for ataraxia, is made possible by living (hiddenly) in the garden in friendship—far from the politics of the polis. These connections lead to the conclusion that the individual self-sufficiency of the human being does not aim at ‘not needing anybody else anymore’, but requires a form of community that should allow the human being the greatest possible freedom within the framework of the Epicurean teachings.
Valerius Maximus on Exceptional Honours—and the Augustan Principate (V. Max. 8.15)
Authors: Westphal Heiko 
Published: September 2023

Abstract
In chapter 8.15 of his Facta et dicta memorabilia, the Tiberian author Valerius Maximus offers his readers a series of historical exempla which depict the grant of extraordinary honours to deserving individuals. Surprisingly, however, Valerius explains that he has no intention of engaging with any of the honours granted to the imperial family. While, so far, Valerius’ claim has not been called into question by modern scholars, this paper seeks to draw attention to the fact that the exemplary material collected by him shows clear parallels to a number of very specific honours granted to Octavian/Augustus. Although it is true that Valerius does not include the members of the domus Augusta among his exemplars in 8.15, the extraordinary honours he chooses to discuss are to be seen as clear precedents of honours granted to Octavian/Augustus and thus also serve to vindicate the creation of the Principate.
Reading Skillfully
Authors: Mulroy Travis 
Published: September 2023

Abstract
This paper examines Socrates’ problematic analogy of reading big and little letters in Book 2 of Plato’s Republic. The examination highlights a significant grammatical detail, which has been generally overlooked in contemporary Platonic scholarship: Socrates refers to the justice of the city as ‘doing one’s own thing’ (τὸ αὑτοῦ πράττων), in the singular, but the justice of the individual as ‘doing one’s own things’ (τὰ αὑτοῦ πράττων), in the plural. In terms of Socrates’ analogy, the big and little letters of justice are not, in fact, the same. Ultimately, the paper argues that Socrates’ analogy of reading big and little letters is intentionally problematic, intended to draw attention to this literal difference between the justice of the city and the justice of the individual. The paper concludes with a discussion of a few immediate implications of this grammatical detail for interpreting the argument of Plato’s Republic.
Rubens and his landscapes: Reflections on the notion of ‘otium’
Authors: Kleinert Corina 
Published: September 2023

This essay sheds light on Peter Paul Rubens’ intentions or possible underlying reasons for the ‘organic’ growth of his landscape paintings by analysing the fundamental contemporary notion of ‘otium’ (fruitful repose). Understood as contemplative leisure encouraging artistic and intellectual endeavour in accordance with Cicero’s advocacy of ‘otium cum dignitate’, it was deeply rooted in the classical writings of Horace, Virgil and Pliny the Younger. Ample research has shown that life in early modern Europe was tempered by the conceptual force of ‘otium’ and its opposite form, ‘negotium’. However, Rubens’ response to this dyad, and especially the effect it had on the creation of his landscapes, has only been addressed superficially.
By teasing out the strands of ‘otium’ and ‘otium ruris’ (fruitful repose in the countryside), the author indicates multiple ways in which the topos of retreat played a notable part in Rubens’ poetic response to nature and landscape, to the aesthetic appreciation of the countryside in real life and in painting. Exploring both places and spaces present in the notions of ‘otium’ and ‘otium ruris’ in Rubens’ day not only consolidates our understanding of the personal dimension of landscapes, but it also sheds new light on the artist’s attentiveness and receptiveness to and his ongoing preoccupation with many of his large compositions in the 1630s.
Although Rubens did not follow the idea of ‘otium’ programmatically, exploring it as a form of contemplative leisure nonetheless offers a key to understand the productive energy, artistic invention, and unique evolution of many of his landscapes. The examination of the important, but hitherto neglected landscape Return from the fields (c.1635-1638) at the Palazzo Pitti in Florence not only provides new insights to the painting’s intriguing genesis, it also demonstrates that Rubens’ landscapes may have provided a growing space of ‘otium ruris’ – for their creator and beholders alike.
External validation of deep learning-based automated detection algorithm for chest radiograph: practical issues in outpatient clinic
Authors: Lee Da Eul , Chae Kum Ju , Jin Gong Yong , Park Seung Yong , Jeong Jae Seok , Ahn Su Yeon 
Published: September 2023

Background There have been no reports on diagnostic performance of deep learning-based automated detection (DLAD) for thoracic diseases in real-world outpatient clinic. Purpose To validate DLAD for use at an outpatient clinic and analyze the interpretation time for chest radiographs. Material and Methods This is a retrospective single-center study. From 18 January 2021 to 18 February 2021, 205 chest radiographs with DLAD and paired chest CT from 205 individuals (107 men and 98 women; mean ± SD age: 63 ± 8 years) from an outpatient clinic were analyzed for external validation and observer performance. Two radiologists independently reviewed the chest radiographs by referring to the paired chest CT and made reference standards. Two pulmonologists and two thoracic radiologists participated in observer performance tests, and the total amount of time taken during the test was measured. Results The performance of DLAD (area under the receiver operating characteristic curve [AUC] = 0.920) was significantly higher than that of pulmonologists (AUC = 0.756) and radiologists (AUC = 0.782) without assistance of DLAD. With help of DLAD, the AUCs were significantly higher for both groups (pulmonologists AUC = 0.853; radiologists AUC = 0.854). A greater than 50% decrease in mean interpretation time was observed in the pulmonologist group with assistance of DLAD compared to mean reading time without aid of DLAD (from 67 s per case to 30 s per case). No significant difference was observed in the radiologist group (from 61 s per case to 61 s per case). Conclusion DLAD demonstrated good performance in interpreting chest radiographs of patients at an outpatient clinic, and was especially helpful for pulmonologists in improving performance.
Factors influence the dignity of burns patients: A cross-sectional study
Authors: Deng YunYun , Yao YiMing , Wang Chang , Tan HuiYi 
Published: September 2023

Background There is a high incidence of burns in China and the sequelae of post-burn scar growth, disfigurement, and other body image disorders can cause serious psychological distress to burns patients, and negatively affecting the patient’s dignity. However, there is limited knowledge relating to the dignity of burns patients. Aim To investigate the factors that affect dignity in burns patients. Design Cross-sectional study. Participants and research context We recruited 323 burn patients from the burn unit of a tertiary care hospital. The Patient Dignity Scale, Burn Specific Health Scale-Brief, Hospital Anxiety and Depression Scale were used to assess burn patients’ dignity, quality of life, anxiety, and depression, respectively. 18 sociodemographic variables were included in the questionnaire. Ethical considerations Before the data were collected, the study protocol was reviewed and approved by the Ethics Committee of the Guangzhou Red Cross Hospital of Jinan University (Reference: 2022-149-02) and all patients provided and signed informed consent forms. Findings This study included 323 burns patients; of these, 26 (8%) had a mild loss of dignity, 94 (29.1%) had a moderate loss of dignity, 125 (38.7%) had a severe loss of dignity, and 78 (24.1%) had a very severe loss of dignity. The main factors that influence the loss of dignity in burns patients, including the department in which the patient was treated after their burns, gender, the clinical stage of the burn, quality-of-life, depression, resident medical insurance, the cause of the burn, and the burn site. Conclusions In most cases, the loss of dignity after burn injury is serious. Clinical health care professionals can provide personalized whole-life dignity care for patients by considering the factors that affect the dignity of burns patients, developing targeted dignity management programs, and implementing individualized interventions to maintain dignity, thus helping burns injury patients return to social life and work.
Bioinformatics, Molecular Docking Simulation and in vitro Experiments Reveal the Bioactive Compounds and Mechanism of Coptis chinensis Franch. Against Colorectal Adenocarcinoma
Authors: Liu Xin , Huang Xu-ying , Liu Zhong , Liu Li , Tu Han 
Published: September 2023

Background Coptis chinensis Franch. (CCF) is a Traditional Chinese medicine known for its good anti-cancer effects. However, the bioactive compounds and mechanisms underlying its anti-colorectal adenocarcinoma (COAD) remains unclear. Objectives This study aims to reveal the bioactive compounds and mechanism of CCF against COAD by utilizing bioinformatics, molecular docking simulation and in vitro experiments. Materials and Methods Bioactive compounds and candidate targets of CCF against COAD were collected using the Traditional Chinese Medicine Systems Pharmacology Database, Analysis Platform (TCMSP), Gene Expression Omnibus (GEO), Gene Cards, and SwissTargetPrediction databases, respectively. The Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were performed using the DAVID (v2022q3) database. The “Compounds-Targets-Pathways” (C-T-P) and “Protein-Protein Interaction” (PPI) networks were constructed using Cytoscape (v3.8.0) to identify the hub targets. AutoDock Vina (v1.2.0), UNLCAN, TCGA, MTT, plate cloning, and quantitative real-time PCR (qPCR) assays were used to confirm the results. Results The “C-T-P” and “PPI” networks revealed three hub targets: checkpoint kinase 1 (CHEK1), polo like kinase 1 (PLK1), and aurora kinase B (AURKB). Molecular docking simulation results showed that berberine, a candidate bioactive compound of CCF, had high affinity with the hub targets, comparable to that of positive drugs. Both CCF ethanol extracts and berberine significantly down-regulated CHEK1, PLK1, and AURKB, inhibited proliferation and promoted apoptosis of HCT-116 cells. Conclusion To summarize, CCF inhibits COAD by down-regulating CHEK1, PLK1, and AURKB, with berberine as its primary bioactive compound.
Effectiveness of ‘Relapse Prevention Therapy’ on High-Risk Situations for Alcohol Use Among Alcohol Dependents
Authors: Sharma Anu , Das Karobi , Sharma Sunita , Ghosh Abhishek 
Published: September 2023

Introduction: Alcohol dependence is a major health concern. It is a progressive and fatal condition influenced by various factors such as heredity, psychology, and environment. There are intrapersonal, interpersonal, and social high-risk situations associated with relapse. Aim: To assess the effectiveness of “relapse prevention therapy” on high-risk situations for alcohol use among alcohol dependents. Methods: A preexperimental design was used. The study was registered with Central Trial Registry of India (CTRI). Total 32 patients from Drug De-addiction and Treatment Centre Out Patient Department (OPD), Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, were selected by using the purposive sampling technique. The tools used for data collection were sociodemographic datasheet cum clinical datasheet of the patient and inventory of drug-taking situations (IDTS-8). Patients received three sessions of relapse prevention therapy. Follow-up was done after eight weeks of relapse prevention therapy. Data was analyzed by both per-protocol analysis and worst-case analysis. Results: All three sessions were completed by 71.9% participants. Participants reported unpleasant emotions as the most frequent cause of their drinking. It was found that there was a significant reduction in alcohol consumption because of high-risk situations ( P =< .05) in both the analysis. Conclusion: Relapse prevention therapy was effective in dealing with high-risk situations for alcohol use.
Effectiveness of Conventional Mirror Therapy on Functional Improvement of Upper Extremities in Patients with Stroke: A Prospective Interventional Study
Authors: D. Lekshmy , Dhandapani Manju , Gupta S. K. , Khurana Dheeraj 
Published: September 2023

Background Stroke is the one of leading causes of death, and paralytic upper extremity (hemiparesis) is a common effect of stroke. The mirror therapy is considered to be an effective therapy to improve muscle strength of upper extremities and activity of daily living of patients with hemiparesis in stroke. Objective To assess the effectiveness of conventional mirror therapy on muscle strength and the activities of daily living in patients of stroke with hemiparesis. Methodology Using total enumeration sampling technique, a prospective interventional study was conducted on 40 patients of stroke receiving conventional mirror therapy in Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh from July to September 2019. Ethical clearance was obtained, and informed written consent was taken from patients. Data was collected by using interview schedule, which comprised of two parts, (a) socio demographic profile and (b) clinical profile, which were collected at the time of enrollment. Functional outcome, that is, muscle strength was assessed by using Wolf Motor Function Scale and Box and Block Test, and activities of daily living were assessed by using Functional Independent Measure at the time of enrolment (baseline). After enrollment of the patients mirror therapy demonstration, pamphlets were given to the patients and follow-ups were done on the first month and third month after interventions. Results There was significant improvement in muscle strength based on Wolf Motor Function Scale (P < .001) and Box and Block Test (P < .001), and in activity of daily living based on Functional Independent Measure (P < .001) from baseline to third month after discharge. Conclusion Conventional mirror therapy is one of the most effective therapies for improving the muscle strength and activity of daily living after stroke in case of hemiparesis.
A Comparative Study to Assess the Mental Health Problems, Quality of Life, Work Ability and Social Adjustments Among OST and Non-OST Drug Users in Chandigarh
Authors: Kumar Pardeep , Sharma Sunita , Saini Sushma Kumari , Mittal Sandeep , Gupta Vanita 
Published: September 2023

Introduction: Injectable drug use is a cause of disease burden and a contributor to blood-borne virus transmission and health-related problems. It is one of the serious problems of our country. The best suitable strategy of treatment for opioid dependence is ‘opioid substitution therapy’ (OST). It is beneficial for the injectable drug users (IDUs) in reduction in the behaviour of injecting and opioid use, which helps in reducing criminal activities, domestic violence, enhancing ties within the family and improving productivity. Objective: To assess the mental health problems, quality of life, work ability and social adjustability among OST and non-OST IDUs. Materials and Methods: The descriptive study was conducted among 100 male IDUs (50 in the OST group and 50 in the non-OST group), registered with the two selected non-governmental organizations (NGOs) of Chandigarh selected by using the consecutive sampling technique. The OST group was contacted during their visit to the centre for receiving the daily dose of OST, while the non-OST group was contacted during their visit to the NGO centres for getting fresh syringes in exchange with used syringes under the syringe exchange programme. The data were collected by interviewing the study subjects by using the interview schedule comprising of the (a) socio-demographic profile, (b) health problems, (c) substance-use-related problems scale, (d) work ability and social adjustability scale, (e) the depression, anxiety and stress scale-21 and (f) World Health Organization Quality-of-Life BREF (WHOQOL BREF) Scale. All the tools were standardized and available in the open domain. Results: The study subjects were in the age group of 18–58 years with the mean age of 27.52 ± 6.67 years. Significantly lesser problems in the OST group study participants related to health, occupation, finance, legal, family, marital and social status were reported than those in the non-OST group participants ( t-test, p < 0.01). A significantly higher percentage of the study participants in the non-OST group had depression, anxiety and stress than that in the OST group. Quality of life of IDUs in the OST group was significantly better than that of IDUs in the non-OST group, as per the WHOQOL BREF Scale (Mann–Whitney U test, p < 0.05). Conclusion: IDUs on OST therapy (OST group) were having lesser problems in the area of health (physical and mental), occupational, financial, legal, family, marital, social and better quality of life than those in the non-OST group.
Sleep Quality Among Patients with Myocardial Infarction
Authors: Suryavanshi M. , Shruti  , Sharma Y. P. 
Published: September 2023

Background: Good sleep is vital for a healthy heart. Studies showed that short sleep duration contributes to the development of myocardial infarction (MI). ST-segment elevated myocardial infarction (STEMI) in comparison to non-ST-segment elevated myocardial infarction (NSTEMI) is considered a dangerous health condition. Sleep qualities among patients with NSTEMI and those with STEMI are less clear in the available literature. So, the author undertook this study. Objective: To assess and compare the sleep quality among patients with STEMI and those with NSTEMI in cardiology units of a tertiary care hospital, Chandigarh. Methodology: The research design was descriptive and the approach used was the quantitative approach. A total of 100 patients were chosen by using the consecutive sampling technique. The interview technique was used to collect data with the help of the interview schedule comprised of socio-demographic profile sheets, clinical profile sheets and the Pittsburgh Sleep Quality Index (to assess the sleep quality). Results: The data revealed that more than 76% of patients were diagnosed with STEMI, whereas less than 24% of patients were diagnosed with NSTEMI. A significantly higher percentage of patients suffering from NSTEMI (40%) reported very good subjective sleep quality than those suffering from STEMI (12%) ( p < 0.05). However, no statistically significant difference was seen in the sleep quality and sleep duration between patients with NSTEMI and those with STEMI as assessed by the Global Sleep Quality Index ( p > 0.05). Conclusion: Each patient, irrespective of their type of MI, reported sleep difficulty. Patients with NSTEMI showed comparatively better sleep quality and sleep duration than those with STEMI. More efforts are required to improve the sleep qualities of patients with both NSTEMI and STEMI for the prevention of secondary cardiovascular events.