bluuebunny/crossref_metadata_2025_split huggingface dataset:
The flax in the “Flora’s image” in the Ariadne House (Pompeian area, Italy) as a symbol of feminine in a wedding sacred to the afterlife
Authors: Caneva G. , Bourmaud A. , Bellini A. , Melelli A. 
Published: July 2023

AbstractIn ancient time, life elements, like plants and animals, and unanimated forces of nature were usually associated with specific meanings related to deities and sacred rituals. In Roman archeology, the strong symbolic value of plants represented in wall paintings and artifacts was proved by several contributions, but this topic is often neglected. In this paper, for the first time, an interpretation is proposed for the plant represented in one of the most iconic paintings in Pompeii, the so-called “Flora” in Ariadne’s house. Here, the analyzed plant is picked by a girl turned away and holding a floral cornucopia, and it plays a relevant role in the scene. Through the analysis of its morphological elements, and comparing them with other ancient representations, we suggest its identification as flax (Linum usitatissimum L.). Flax was an economically and culturally very important plant, widely represented in objects and paintings in the Mesopotamian and Egyptian area. We also suggest that the meaning behind the choice of depict flax was also related to its classical attribution as a symbol of fertility and afterlife as well as linked to the “feminine” sphere. This interpretation, together with other elements of the images, strengthens the already proposed interpretation of the yellow-dressed girl a wife, which is let to go this life for an afterlife, in the figure of Persephone.
Graphical abstract
RIPK1 is aberrantly expressed in multiple B-cell cancers and implicated in the underlying pathogenesis
Authors: Wu Baoyu , Li Jingyu , Wang Han , Liu Jianguo , Li Jiayong , Sun Fang , Feng Dong chuan 
Published: July 2023

AbstractAccording to the latest epidemiology of the US, B-cell cancers account for > 3% of all new cancer cases and > 80% of non-Hodgkin lymphomas. However, the disease-modifying small molecular drug suitable for most B-cell cancers is still lacking. RIPK1 (receptor-interacting serine/threonine-protein kinase 1) has been observed to be dysregulated and implicated in the pathogenesis of multiple solid cancers, of which, however, the roles in blood cancers are quite unclear. In our study, to identify multi-function targets for B-cell cancer treatment, we reanalyzed a public transcriptomic dataset from the database of Gene Expression Omnibus, which includes CD19+ B-cell populations from 6 normal donors and patients of 5 CLL, 10 FL, and 8 DLBCL. After overlapping three groups (CLL vs. normal, FL vs. normal, and DLBCL vs. normal) of differentially expressed genes (DEGs), we obtained 69 common DEGs, of which 3 were validated by real-time quantitative PCR, including RIPK3, IGSF3, TGFBI. Interestingly, we found that the loss function of RIPK1 significantly increases the proliferation and viability of GM12878 cells (a normal human B lymphocyte cell line). Consistently, overexpression of RIPK1 in TMD8 and U2932 cells effectively inhibited cell proliferation and growth. More importantly, modifying RIPK1 kinase activity by a small molecule (such as necrostain-1, HOIPIN-1, etc.) alters the cell growth status of B-cell lymphoma, showing that RIPK1 exhibits anti-tumor activity in the context of B-cell lymphoma. Taken together, we consider that RIPK1 may be a potential target in the clinical application of B-cell lymphoma (including CLL, DLBCL, and FL) treatment.
Erwerb von sozialer und emotionaler Kompetenz im Bachelorstudium der Sozialen Arbeit: Eine explorative Annäherung
Authors: Schliermann Rainer , Rock Jasmin , Schroll-Decker Irmgard 
Published: July 2023

ZusammenfassungStudiengänge Sozialer Arbeit zielen auf die Ausbildung sozialpädagogischer Professionalität. In den Modulhandbüchern wird neben der Fachkompetenz die Förderung sozialer (und emotionaler) Kompetenzen als Lernziel adressiert. Ob sich letztere durch die gängigen formellen Lernsettings und der integrierten Praxisphase(n) entwickeln lassen, bleibt unklar. Die Studie analysiert anhand von 264 validierten Fragebögen, inwiefern formelle Lernsettings einer Hochschule für angewandte Wissenschaften (HAW) mit der Förderung sozialer und emotionaler Kompetenzen einhergehen. Es lassen sich kaum statistisch signifikante Effekte nachweisen. Da die formellen Lernsettings kaum Einfluss auf die Entwicklung der genannten Kompetenzen haben, sind Implikationen für veränderte formelle Lernarrangements zu diskutieren.
Clinicopathological and prognostic significance of PD-L1 and TIM-3 expression in medullary thyroid carcinoma: a retrospective immunohistochemistry study
Authors: Wusiman D. , Guo L. , Li L. , Zhang X. , Zhao X. , An Z. , Huang Z. , Zhang Y. , Li Z. , Ying J. , Wei M. , Li W. , An C. 
Published: July 2023

Abstract
Purpose
Expression of the programmed death-ligand 1 (PD-L1) and T-cell immunoglobulin and mucin-domain containing-3 (TIM-3) in medullary thyroid carcinoma (MTC) has been controversial and rarely reported.

Methods
Surgical specimens of 190 MTC patients who had initial curative-intent surgery were collected. Immunohistochemistry of PD-L1 and TIM-3 was performed using 22C3 pharmDx (Dako, Carpinteria, CA) and anti-TIM-3 (1:500, ab241332, Abcam). Stained slides were scored using a combined positive score (CPS) with a cutoff of ≥ 1. We established correlations between PD-L1 expression, TIM-3 expression, clinicopathological, and survival data.

Results
13 cases (13/190, 6.84%) were positive for PD-L1 expression, and 42 cases (42/154, 27.27%) for TIM-3 expression. PD-L1 expression was correlated to TIM-3 expression (P = 0.002), but was not related to overall survival (OS) or progression-free survival (PFS). TIM-3 expression was correlated to perineural invasion (P = 0.040). Multivariate Cox analysis showed that lymphovascular invasion (LVI) was independently associated with OS. And tumor size, LVI, and lymph node metastases were significantly associated with PFS. Furthermore, the multivariate logistic analysis showed multifocal status, LVI, pathological T stage and lymph node metastasis were independent risk factors for biochemical recurrence/persistent disease.

Conclusions
We demonstrated that PD-L1 and TIM-3 expression were not frequent in MTC and were not associated with survival prognosis. Our results should be considered when clinical trials of PD-L1 or TIM-3 blockades are implemented.
Augmented reality applications for mathematical creativity: a systematic review
Authors: Hidajat Flavia Aurelia 
Published: July 2023

AbstractAugmented reality (AR) applications are often studied in education. However, little literature has systematically reviewed the applications of AR for mathematical creativity. This paper aims to analyze the research trends comprehensively and systematically on 66 articles from 2015 to 2023. Based on the NCTM Principles and Standards guidelines, trends in the application of AR in mathematics education can be analyzed into six themes: equity, mathematics curriculum, mathematics teaching, learning, assessment, and mathematics technology. The results of the study show that (1) AR for mathematical creativity has implications for improving students' cognitive performance; problem-solving process; self-potential; social skills, and self-ability of students; (2) the most dominant features in developing AR applications for mathematical creativity are the Unity3D tool and Vuforia; (3) AR has a positive impact on equity for improving the quality of teaching and learning, supporting the educational curriculum; improve the teaching and learning of mathematics; effective evaluation and technology development in the learning process; (4) AR as a creative learning media; AR helps creative collaboration between students; and able to improve students' creative thinking skills. The results of a systematic review of AR applications for mathematical creativity can help educators and the development of future educational research.
Coronavirus disease 2019 (COVID-19) universal admission screening in patients and companions in Taiwan from May 2021 to June 2022: A nationwide multicenter study
Authors: Wu Hao-Hsin , Su Chiu-Hsia , Chien Li-Jung , Tseng Shu-Hui , Chang Shan-Chwen 
Published: July 2023

AbstractObjective:Universal admission screening and follow-up symptom-based testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may play critical roles in controlling nosocomial transmission. We describe the performance of test strategies for inpatients and their companions during various disease incidences in Taiwan.Design:Retrospective population-based cohort study.Setting:The study was conducted across 476 hospitals in Taiwan.Methods:The data for both testing strategies by reverse transcription-polymerase chain reaction for SARS-CoV-2 in newly admitted patients and their companions during May 2021—June 2022 were extracted and analyzed.Results:The positivity rate of universal admission screening was 0.76% (14,640 of 1,928,676) for patients and 0.37% (5,372 of 1,438,944) for companions. The weekly community incidences of period 1 (May 2021–June 2021), period 2 (July 2021–March 2022), and period 3 (April 2022–June 2022) were 6.57, 0.27, and 1,261, respectively, per 100,000 population. The positivity rates of universal admission screening for patients and companions (4.39% and 2.18%) in period 3 were higher than those in periods 1 (0.29% and 0.04%) and 2 (0.03% and 0.003%) (all P < .01). Among the 22,201 confirmed cases, 9.86% were identified by symptom-based testing. The costs and potential savings of universal admission screening for patients and companions achieved a breakeven point when the test strategy was implemented in a period with weekly community incidences of 27 and 358 per 100,000 population, respectively.Conclusions:Universal admission screening and follow-up symptom-based testing is important for reducing nosocomial transmission. Implementing universal admission screening at an appropriate time would balance the benefits with costs and potential unintended harms.
Scandinavian entry points to social medicine and postcolonial health: Karl Evang and Halfdan Mahler in India
Authors: Engh Sunniva , Brimnes Niels 
Published: July 2023

AbstractOur contributions examine the Norwegian Karl Evang's (1901-1981) and the Dane Halfdan Mahler's (1923-2016) participation in international health co-operation facilitated by the World Health Organization (WHO) in India in the 1950s. While Evang’s was a hectic, but relatively short visit as part of a WHO visiting team of medical scientists in 1953, Mahler’s spanned the entire decade on assignments as WHO medical officer to tuberculosis control projects. Mahler’s name should be familiar to researchers of international health as the Director-General of the WHO 1973-88, and for his promotion of primary health care through the 1978 Alma-Ata Declaration. Evang, Norway’s Director of Health 1938-72, was also a key figure in international health in the mid-twentieth century as one of the original instigators of the WHO, and a participant in much of its early work.A core theme is the place of social medicine, both in Evang’s and Mahler’s work, and within the WHO and its navigation of complex postcolonial settings in the 1950s. Investigating cross-regional encounters and circulations of social medicine ideas between Evang and Mahler and their Indian interlocutors as well as international WHO staff members, we ask what the role of social medicine was in international health in the early post-war period. Researchers have found that social medicine had its heyday during the 1930s and 1940s, and that a technology-focused, vertical approach became dominant soon after the war. In contrast, we suggest that continued circulation of social medical ideas points towards a more complicated picture.
Switching: Cultural fluency sustains and cultural disfluency disrupts thinking fast
Authors: Oyserman Daphna 
Published: July 2023

Abstract
Culture-as-situated cognition theory provides insight into the system 1 monitoring algorithm. Culture provides people with an organizing framework, facilitating predictions, focusing attention, and providing experiential signals of certainty and uncertainty as system 1 inputs. When culture-based signals convey that something is amiss, system 2 reasoning is triggered and engaged when resources allow; otherwise, system 1 reasoning dominates.
Gradient-based parameter calibration of an anisotropic interaction model for pedestrian dynamics
Authors: Turarov Zhomart , Totzeck Claudia 
Published: July 2023

AbstractWe propose an extension of the anisotropic interaction model which allows for collision avoidance in pairwise interactions by a rotation of forces (Totzeck (2020) Kinet. Relat. Models13(6), 1219–1242.) by including the agents’ body size. The influence of the body size on the self-organisation of the agents in channel and crossing scenarios as well as the fundamental diagram is studied. Since the model is stated as a coupled system of ordinary differential equations, we are able to give a rigorous well-posedness analysis. Then we state a parameter calibration problem that involves data from real experiments. We prove the existence of a minimiser and derive the corresponding first-order optimality conditions. With the help of these conditions, we propose a gradient descent algorithm based on mini-batches of the data set. We employ the proposed algorithm to fit the parameter of the collision avoidance and the strength parameters of the interaction forces to given real data from experiments. The results underpin the feasibility of the method.
East Indian misfortunes: the Fraser brothers and the early Raj
Authors: Minault Gail 
Published: July 2023

AbstractNothing in William Fraser's life in India is better known than his leaving of it. In March 1835, after 30 years in India, Fraser, then the East India Company's chief representative in Delhi, was gunned down by an assassin. The story of Fraser's murder is well covered in history. However, far more of Fraser's life in India—and that of his brothers—is discernible through their letters home to their family in Reelig, outside Inverness in Scotland.The Frasers sent five sons to India: William, his older brother James, and their three younger siblings, Edward, Alexander, and George. Only James ultimately returned home. If service in the East India Company in the time of Clive had offered the chance of making a killing, so too was it possible to die young of disease or in battle. By the early nineteenth century, after a series of Company reforms, it was no longer as possible to make a huge fortune in India, though early death was still a probability. Nevertheless, salaries were respectable, and one could live well and maybe even send money home. There is a great deal more than these material considerations in the Frasers’ correspondence. Among the topics covered are the brothers’ impressions of India, descriptions of travel and working life, their professional and social interactions with the British and Indians, and reflections on the contemporary state of medical care. This article will discuss the lives and travails of the Fraser brothers as exemplars of their generation of East India Company officialdom.
External Behavior of a Logic Program and Verification of Refactoring
Authors: FANDINNO JORGE , HANSEN ZACHARY , LIERLER YULIYA , LIFSCHITZ VLADIMIR , TEMPLE NATHAN 
Published: July 2023

AbstractRefactoring is modifying a program without changing its external behavior. In this paper, we make the concept of external behavior precise for a simple answer set programming language. Then we describe a proof assistant for the task of verifying that refactoring a program in that language is performed correctly.
Revisiting the Origins of the Power‐Law Analysis for the Assessment of Concentration‐Discharge Relationships
Authors: Wymore Adam S. , Larsen William , Kincaid Dustin W. , Underwood Kristen L. , Fazekas Hannah M. , McDowell William H. , Murray Desneiges S. , Shogren Arial J. , Speir Shannon L. , Webster Alex J. 
Published: July 2023

AbstractConcentration‐discharge (C‐Q) relationships are frequently used to understand the controls on material export from watersheds. These analyses often use a log‐log power‐law function (C = aQb) to determine the relationship between C and Q. Use of the power‐law in C‐Q analyses dates to two seminal papers by Francis Hall (1970, https://doi.org/10.1029/WR006i003p00845) and Francis Hall (1971, https://doi.org/10.1029/WR007i003p00591), where he compared six increasingly complex hydrological models, concluding the power‐law had the greatest explanatory power. Hall's analyses and conclusions, however, were based on a limited data set, with assumptions regarding water volume and storage, and used simple model selection criteria. While the power‐law is applied widely, it has not been rigorously tested and evaluated in over 50 years. We reexamined Hall's original models across time scales using 8 years of high‐frequency and weekly specific conductance data and evaluated model performance using more sophisticated model selection criteria. While we found the power‐law analysis remains one of the best performing models, other models performed equally as well including the log‐linear functional form. Model performance was similar at the sub‐daily to weekly scale but varied with sampling method. More complex models performed poorly relative to simpler models and tended to underpredict concentration at flow extremes due to constraints in fitting model parameters to the observed data. While we conclude, based on the data analyzed here, that the power‐law remains a suitable model for C‐Q analyses, opportunities exist to refine and differentiate among C‐Q models based on underlying assumptions of data distribution, recession analyses, and for applying models to reactive solutes.
Primary sclerosing cholangitis (PSC) and inflammatory bowel disease (IBD): a condition exemplifying the crosstalk of the gut–liver axis
Authors: Kim You Sun , Hurley Edward H. , Park Yoojeong , Ko Sungjin 
Published: July 2023

AbstractThe close relationship between primary sclerosing cholangitis (PSC) and inflammatory bowel disease (IBD) provides a good opportunity to comprehend the gut–liver axis. The gut and the liver have reciprocal interactions, including how gut inflammation influences the liver through immune cells and the microbiota and how the microbiota in the gut modifies bile acids, which are produced and secreted from the liver. PSC-IBD shows distinct clinical findings from classical IBD. In addition, a distinct genetic predisposition and unique microbiota composition suggest that PSC-IBD is an independent disease entity. Understanding the pathogenesis of PSC-IBD helps to develop novel and effective therapeutic agents. Given the high risk of malignancies associated with PSC-IBD, it is critical to identify patients at high risk and implement appropriate surveillance and monitoring strategies. In this review, we provide an overview of PSC-IBD, which exemplifies the gut–liver axis.
Evidence and reporting standards in N-of-1 medical studies: a systematic review
Authors: Natesan Batley Prathiba , McClure Erica B. , Brewer Brandy , Contractor Ateka A. , Batley Nicholas John , Hedges Larry Vernon , Chin Stephanie 
Published: July 2023

AbstractN-of-1 trials, a special case of Single Case Experimental Designs (SCEDs), are prominent in clinical medical research and specifically psychiatry due to the growing significance of precision/personalized medicine. It is imperative that these clinical trials be conducted, and their data analyzed, using the highest standards to guard against threats to validity. This systematic review examined publications of medical N-of-1 trials to examine whether they meet (a) the evidence standards and (b) the criteria for demonstrating evidence of a relation between an independent and an outcome variable per the What Works Clearinghouse (WWC) standards for SCEDs. We also examined the appropriateness of the data analytic techniques in the special context of N-of-1 designs. We searched for empirical journal articles that used N-of-1 design and published between 2013 and 2022 in PubMed and Web of Science. Protocols or methodological papers and studies that did not manipulate a medical condition were excluded. We reviewed 115 articles; 4 (3.48%) articles met all WWC evidence standards. Most (99.1%) failed to report an appropriate design-comparable effect size; neither did they report a confidence/credible interval, and 47.9% reported neither the raw data rendering meta-analysis impossible. Most (83.8%) ignored autocorrelation and did not meet distributional assumptions (65.8%). These methodological problems could lead to significantly inaccurate effect sizes. It is necessary to implement stricter guidelines for the clinical conduct and analyses of medical N-of-1 trials. Reporting neither raw data nor design-comparable effect sizes renders meta-analysis impossible and is antithetical to the spirit of open science.
Chromatin regulators in the TBX1 network confer risk for conotruncal heart defects in 22q11.2DS
Authors: Zhao Yingjie , Wang Yujue , Shi Lijie , McDonald-McGinn Donna M. , Crowley T. Blaine , McGinn Daniel E. , Tran Oanh T. , Miller Daniella , Lin Jhih-Rong , Zackai Elaine , Johnston H. Richard , Chow Eva W. C. , Vorstman Jacob A. S. , Vingerhoets Claudia , van Amelsvoort Therese , Gothelf Doron , Swillen Ann , Breckpot Jeroen , Vermeesch Joris R. , Eliez Stephan , Schneider Maude , van den Bree Marianne B. M. , Owen Michael J. , Kates Wendy R. , Repetto Gabriela M. , Shashi Vandana , Schoch Kelly , Bearden Carrie E. , Digilio M. Cristina , Unolt Marta , Putotto Carolina , Marino Bruno , Pontillo Maria , Armando Marco , Vicari Stefano , Angkustsiri Kathleen , Campbell Linda , Busa Tiffany , Heine-Suñer Damian , Murphy Kieran C. , Murphy Declan , García-Miñaúr Sixto , Fernández Luis ,   International 22q11.2 Brain and Behavior Consortium (IBBC), Busa Tiffany , Zhang Zhengdong D. , Goldmuntz Elizabeth , Gur Raquel E. , Emanuel Beverly S. , Zheng Deyou , Marshall Christian R. , Bassett Anne S. , Wang Tao , Morrow Bernice E. 
Published: July 2023

AbstractCongenital heart disease (CHD) affecting the conotruncal region of the heart, occurs in 40–50% of patients with 22q11.2 deletion syndrome (22q11.2DS). This syndrome is a rare disorder with relative genetic homogeneity that can facilitate identification of genetic modifiers. Haploinsufficiency of TBX1, encoding a T-box transcription factor, is one of the main genes responsible for the etiology of the syndrome. We suggest that genetic modifiers of conotruncal defects in patients with 22q11.2DS may be in the TBX1 gene network. To identify genetic modifiers, we analyzed rare, predicted damaging variants in whole genome sequence of 456 cases with conotruncal defects and 537 controls, with 22q11.2DS. We then performed gene set approaches and identified chromatin regulatory genes as modifiers. Chromatin genes with recurrent damaging variants include EP400, KAT6A, KMT2C, KMT2D, NSD1, CHD7 and PHF21A. In total, we identified 37 chromatin regulatory genes, that may increase risk for conotruncal heart defects in 8.5% of 22q11.2DS cases. Many of these genes were identified as risk factors for sporadic CHD in the general population. These genes are co-expressed in cardiac progenitor cells with TBX1, suggesting that they may be in the same genetic network. The genes KAT6A, KMT2C, CHD7 and EZH2, have been previously shown to genetically interact with TBX1 in mouse models. Our findings indicate that disturbance of chromatin regulatory genes impact the TBX1 gene network serving as genetic modifiers of 22q11.2DS and sporadic CHD, suggesting that there are some shared mechanisms involving the TBX1 gene network in the etiology of CHD.