bluuebunny/crossref_metadata_2025_split huggingface dataset:
A jolt to the system: ram pressure on low-mass galaxies in simulations of the Local Group
Authors: Samuel Jenna , Pardasani Bhavya , Wetzel Andrew , Santistevan Isaiah , Boylan-Kolchin Michael , Moreno Jorge , Faucher-Giguère Claude-André 
Published: August 2023

ABSTRACT
Low-mass galaxies are highly susceptible to environmental effects that can efficiently quench star formation. We explore the role of ram pressure in quenching low-mass galaxies ($M_{*}\sim 10^{5}{-}10^{9}\, \rm {M}_{\odot }$) within 2 Mpc of Milky Way (MW) hosts using the FIRE-2 simulations. Ram pressure is highly variable across different environments, within individual MW haloes, and for individual low-mass galaxies over time. The impulsiveness of ram pressure – the maximum ram pressure scaled to the integrated ram pressure prior to quenching – correlates with whether a galaxy is quiescent or star forming. The time-scale between maximum ram pressure and quenching is anticorrelated with impulsiveness, such that high impulsiveness corresponds to quenching time-scales &lt;1 Gyr. Galaxies in low-mass groups ($M_\mathrm{*,host}10^{7}{-}10^{9}\, \rm {M}_{\odot }$) outside of MW haloes experience typical ram pressure only slightly lower than ram pressure on MW satellites, helping to explain effective quenching via group preprocessing. Ram pressure on MW satellites rises sharply with decreasing distance to the host, and, at a fixed physical distance, more recent pericentre passages are typically associated with higher ram pressure because of greater gas density in the inner host halo at late times. Furthermore, the ram pressure and gas density in the inner regions of Local Group-like paired host haloes are higher at small angles off the host galaxy disc compared to isolated hosts. The quiescent fraction of satellites within these low-latitude regions is also elevated in the simulations and observations, signaling possible anisotropic quenching via ram pressure around MW-mass hosts.
Multimessenger parameter inference of gravitational-wave and electromagnetic observations of white dwarf binaries
Authors: Johnson Peyton T , Coughlin Michael W , Hamilton Ashlie , Bustamante-Rosell María José , Ashton Gregory , Corey Samuel , Kupfer Thomas , Littenberg Tyson B , Reed Draco , Zimmerman Aaron 
Published: August 2023

ABSTRACT
The upcoming Laser Interferometer Space Antenna (LISA) will detect a large gravitational-wave foreground of Galactic white dwarf binaries. These sources are exceptional for their probable detection at electromagnetic wavelengths, some long before LISA flies. Studies in both gravitational and electromagnetic waves will yield strong constraints on system parameters not achievable through measurements of one messenger alone. In this work, we present a Bayesian inference pipeline and simulation suite in which we study potential constraints on binaries in a variety of configurations. We show how using LISA detections and parameter estimation can significantly improve constraints on system parameters when used as a prior for the electromagnetic analyses. We also provide rules of thumb for how current measurements will benefit from LISA measurements in the future.
Implementation of Hepatitis B Screening Into Routine Antenatal Care to Prevent Mother-to-Child Transmission in Rural Western Uganda
Authors: Thahir Sahal , Muhindo Enid , Turigye Brian , Kabagambe Kenneth , Thompson Peyton , Mulogo Edgar M , Boyce Ross M 
Published: August 2023

Abstract
In rural Uganda where birth dose vaccination for hepatitis B is not routine, we implemented a pilot program for preventing mother-to-child transmission that effectively identified women with high-risk hepatitis B virus (HBV) infection and started antiviral treatment during pregnancy. Further work is required to enhance antiviral adherence through delivery to ensure effective prevention of vertical HBV transmission.
Veridicalism and Scepticism
Authors: Avnur Yuval 
Published: August 2023

Abstract
According to veridicalism, your beliefs about the existence of ordinary objects are typically true, and can constitute knowledge, even if you are in some global sceptical scenario. Even if you are a victim of Descartes’ demon, you can still know that there are tables, for example. Accordingly, even if you don’t know whether you are in some such scenario, you still know that there are tables. This refutes the standard sceptical argument. But does it solve the sceptical problem posed by that argument? I argue that it does not, because we do not know substantively more about the external world according to veridicalism than we do according to the sceptical argument. Rather, veridicalism merely reformulates what little knowledge we have. I then draw some general conclusions about the nature of the sceptical problem, the formulation of the standard argument, and the significance of this for some other, non-veridicalist strategies.
Grandparenting during pandemic times: pros and cons for mental health
Authors: Vigezzi Giacomo Pietro , Bertuccio Paola , Amerio Andrea , Bottini Gabriella , Gandola Martina , Cavalieri d’Oro Luca , Iacoviello Licia , Stuckler David , Signorelli Carlo , Zucchi Alberto , Gallus Silvano , Odone Anna ,   Lost in Lombardia Project Investigators, Amerio A , Amore M , Bertuccio P , Bonaccio M , Bosetti C , Cavalieri d’Oro L , Ciampichini R , De Sena R , Gallus S , Gianfagna F , Ghislandi S , Ghulam A , Iacoviello L , Jarach C M , Lugo A , Mosconi G , Odone A , Rognoni M , Serafini G , Scala M , Signorelli C , Stival C , Stuckler D , Vigezzi G P , Wang Y , Zucchi A 
Published: August 2023

Abstract

Background
The COVID-19 pandemic and associated lockdown measures posed an unprecedented challenge to the crucial role of grandparenting in family-oriented cultures, such as Italy. Reduced contact with grandchildren during this period potentially threatened grandparents’ mental health and well-being.

Methods
We analysed data from the LOckdown and lifeSTyles in Lombardia cross-sectional study conducted in November 2020. The study included a representative sample of 4400 older adults from Lombardy, Italy, of which 1289 provided childcare to their grandchildren.

Results
A decrease in self-reported grandparenting was associated with an increased likelihood of experiencing depressive symptoms among grandparents (OR 1.50, 95% CI 1.01–2.24). Conversely, an increase in grandparenting was linked to poorer sleep quality (OR 11.67, 95% CI 5.88–23.17) and reduced sleep quantity (OR 2.53, 95% CI 1.45–4.41).

Conclusions
Despite the barriers posed by the pandemic, grandparenting played a beneficial role in maintaining the mental health and well-being of older adults. However, it is crucial to recognise specific vulnerabilities, such as gender, feelings of hopelessness and overcrowding, which can have detrimental effects during and beyond emergency situations. Careful attention to these factors is essential for developing targeted support systems and interventions aimed at safeguarding the mental health of older adults and enhancing their resilience in crises.
A millimetre-wave superconducting hyper-spectral device
Authors: Chowdhury U , Calvo M , Goupy J , Levy-Bertrand F , Monfardini A 
Published: August 2023

Abstract
Millimetre-wave observations represent an important tool for cosmology studies. The line intensity mapping technique has been proposed to map in three dimensions the specific intensity due to line (e.g. [C ii] and CO) emission, e.g. from the primordial galaxies, as a function of redshift. Hyper-spectral integrated devices have the potential to replace the current Fourier transform, or the planned Fabry–Perot-based instruments operating at millimetre and sub-millimetre wavelengths. The aim is to perform hyper-spectral mapping, with a spectral resolution R = λ/Δλ = 100–1000, over large, i.e. thousands of beams, instantaneous patches of the sky. The innovative integrated device that we have developed allows avoiding moving parts, complicated and/or dispersive optics, or tunable filters to be operated at cryogenic temperatures. The prototype hyper-spectral focal plane is sensitive in the 75- to 90-GHz range and contains 19 horns for 16 spectral-imaging channels, each selecting a frequency band of about 0.1 GHz. For each channel a conical horn antenna, coupled to a planar superconducting resonant absorber made of thin aluminium, collects the radiation. A capacitively coupled titanium–aluminium bi-layer Lumped Element Kinetic Inductance Detector is then in charge of dissipating and sensing the supercurrent established in the resonant absorber. The prototype is fabricated with only two photolithography steps over a commercial mono-crystalline sapphire substrate. It exhibits a spectral resolution R = λ/Δλ ≈ 800. The optical noise equivalent power of the best channels is in the observational relevant $4\cdot 10^{-17} W/\sqrt{Hz}$ range. The average sensitivity of all the channels is around $1\cdot 10^{-16} W/\sqrt{Hz}$. The device, as expected from three-dimensional simulations, is polarization-sensitive, paving the way to spectro-polarimetry measurements over very large instantaneous field of views.
Renal relapse in children and adolescents with childhood-onset lupus nephritis: a 20-year study
Authors: Chan Eugene Yu-hin , Yap Desmond Yat-hin , Wong Wilfred Hing-sang , Wong Sze-wa , Lin Kyle Ying-kit , Hui Felix Yan-wai , Li Jennifer Yee-ming , Lam Sophia Suet-ying , Wong Jennie Kit-yee , Lai Fiona Fung-yee , Ho Tsz-wai , Tong Pak-chiu , Lai Wai-ming , Chan Tak Mao , Ma Alison Lap-tak 
Published: August 2023

Abstract

Objectives
There is little data on renal relapse in childhood-onset LN (cLN). We investigate the incidence, predictive factors and outcomes related to renal relapse.

Methods
We conducted a retrospective cohort study of all cLN diagnosed at ≤18 years between 2001–2021 to investigate the incidence and outcomes related to renal relapse.

Results
Ninety-five Chinese cLN patients (91% proliferative LN) were included. Induction immunosuppression was prednisolone and CYC [n = 36 (38%)] or MMF [n = 33 (35%)]. Maintenance immunosuppression was prednisolone and MMF [n = 53 (54%)] or AZA [n = 29 (31%)]. The rates of complete remission/partial remission (CR/PR) at 12 months were 78.9%/7.4%. Seventy renal relapses occurred in 39 patients over a follow-up of 10.2 years (s.d. 5.9) (0.07 episode/patient-year). Relapse-free survival was 94.7, 86.0, 80.1, 71.2, 68.3, 50.3 and 44.5% at 1, 2, 3, 4, 5, 10 and 20 years, respectively. Multivariate analysis showed that LN diagnosis &lt;13.1 years [adjusted hazard ratio (HRadj) 2.59 995% CI 1.27, 5.29), P = 0.01], AZA maintenance [HRadj 2.20 (95% CI 1.01, 4.79), P = 0.05], PR [HRadj 3.9 (95% CI 1.03, 9.19), P = 0.01] and non-remission [HRadj 3.08 (95% CI 1.35, 11.3), P = 0.04] at 12 months were predictive of renal relapse. Renal relapse was significantly associated with advanced chronic kidney disease (stages 3–5) and end-stage kidney disease (17.9% vs 1.8%, P &lt; 0.01). Furthermore, patients with renal relapse showed an increased incidence of infections (30.8% vs 10.7%, P = 0.02), osteopenia (38.5% vs 17.9%, P = 0.04) and hypertension (30.8% vs 7.1%, P &lt; 0.01).

Conclusion
Renal relapse is common among cLN, especially among young patients, and is associated with an increased incidence of morbidity and mortality. Attaining CR and the use of MMF appear to decrease the incidence of renal relapse.
Openness to Experience is associated with neural and performance measures of memory in older adults
Authors: Stolz Christopher , Bulla Ariane , Soch Joram , Schott Björn H , Richter Anni 
Published: August 2023

AbstractAge-related decline in episodic memory performance is a well-replicated finding across numerous studies. Recent studies focusing on aging and individual differences found that the Big Five personality trait Openness to Experience (hereafter: Openness) is associated with better episodic memory performance in older adults, but the associated neural mechanisms are largely unclear. Here, we investigated the relationship between Openness and memory network function in a sample of 352 participants (143 older adults, 50–80 years; 209 young adults, 18–35 years). Participants underwent functional magnetic resonance imaging (fMRI) during a visual memory encoding task. Functional memory brain–network integrity was assessed using the similarity of activations during memory encoding (SAME) scores, which reflect the similarity of a participant’s memory network activity compared to prototypical fMRI activity patterns of young adults. Openness was assessed using the NEO Five-Factor Inventory. Older vs young adults showed lower memory performance and higher deviation of fMRI activity patterns (i.e. lower SAME scores). Specifically in older adults, high Openness was associated with better memory performance, and mediation analysis showed that this relationship was partially mediated by higher SAME scores. Our results suggest that trait Openness may constitute a protective factor in cognitive aging by better preservation of the brain’s memory network.
Latent Cumulative Disadvantage: US Immigrants’ Reversed Economic Assimilation in Later Life
Authors: Ye Leafia Z 
Published: August 2023

Abstract
One of the most salient findings in research on immigration has been that immigrants experience substantial economic mobility as they accumulate more years in the host-society labor force and eventually approach earnings parity with their native-born counterparts. However, we do not know whether this progress is sustained in retirement. In this paper, I develop a framework of Latent Cumulative (Dis)advantage and hypothesize that even as immigrants are approaching parity with the native-born in terms of current earnings, they accumulate disadvantages in lifetime earnings, job benefits, and retirement planning that eventually lead them to have growing disadvantages in income in later life. Drawing on decades of longitudinal data from the Health and Retirement Study, I find that while foreign- and native-born men in the United States both experience a decline in income after age 50, the decline is much more substantial among foreign-born men. As a result, immigrant men’s economic assimilation is reversed in later life. I find evidence that this phenomenon is driven mainly by immigrants’ lower lifetime earnings and cumulative exposure to worse job benefits. Given that the foreign-born elderly population in the United States is projected to quadruple by 2050, findings from this paper have important implications for long-term policy planning.
Production and Limbal Lineage Commitment of Aniridia Patient-Derived Induced Pluripotent Stem Cells
Authors: Ilmarinen Tanja , Vattulainen Meri , Kandhavelu Jeyalakshmi , Bremond-Gignac Dominique , Aberdam Daniel , Skottman Heli 
Published: August 2023

Abstract
Congenital aniridia is caused by heterozygous mutations on the PAX6 gene leading to reduced amount of PAX6 protein (haploinsufficiency), abnormal eye development, and aniridia-associated keratopathy (AAK). This progressive corneal opacification resembles late-onset limbal stem cell (LSC) deficiency, leading to disrupted corneal epithelial renewal. The factors leading to AAK are not known and defects in native LSC differentiation and/or features leading to ocular surface dysfunction like inflammation and loss of innervation could contribute to development of AAK. Here, we produced induced pluripotent stem cells (hiPSC) from 3 AAK patients and examined whether PAX6 haploinsufficiency affects LSC lineage commitment. During LSC differentiation, characterization of the AAK lines showed lowered PAX6 expression as compared to wild type (WT) controls and expression peak of PAX6 during early phase of differentiation was detected only in the WT hiPSC lines. Whether it reflects developmental regulation remains to be studied further. Nevertheless, the AAK-hiPSCs successfully differentiated toward LSC lineage, in line with the presence of LSCs in young patients before cell loss later in life. In addition, patient-specific LSCs showed similar wound healing capacity as WT cells. However, extensive batch-related variation in the LSC marker expression and wound healing efficacy was detected without clear correlation to AAK. As development and maintenance of corneal epithelium involves an interplay between LSCs and their environment, the AAK-hiPSCs generated here can be further used to study the crosstalk between LSCs and limbal niche including, eg, corneal immune cells, stroma cells, and neurons.
Family-based pediatric weight management interventions in US primary care settings targeting children ages 6–12 years old: A systematic review guided by the RE-AIM framework
Authors: Yudkin Joshua S , Koym Kelsey , Hamad Yasmin , Malthaner Lauren Q , Burgess Rebecca Meredith , Ortiz Leslie N , Dhurjati Nalini , Mitha Sharmin , Calvi Gabriela , Hill Kristina , Brownell Mckenna , Wei Elena , Swartz Kyle , Atem Folefac D , Galeener Carol A , Messiah Sarah E , Barlow Sarah E , Allicock Marlyn A 
Published: August 2023

AbstractObesity is a pandemic that disproportionately affects children from vulnerable populations in the USA. Current treatment approaches in primary care settings in the USA have been reported to be insufficient at managing pediatric obesity, primarily due to implementation challenges for healthcare systems and barriers for families. While the literature has examined the efficacy of pediatric obesity interventions focused on internal validity, it lacks sufficient reporting and analysis of external validity necessary for successful translation to primary care settings. We conducted a systematic review of the primary-care-setting literature from January 2007 to March 2020 on family-based pediatric weight management interventions in both English and/or Spanish for children ages 6–12 years in the USA using the Reach, Efficacy/Effectiveness, Adoption, Implementation, Maintenance (RE-AIM) framework. A literature search, using PRISMA guidelines, was conducted in January 2022 using the following electronic databases: Medline Ovid, Embase, and Cochrane Library. 22 270 records were screened, and 376 articles were reviewed in full. 184 studies were included. The most commonly reported dimensions of the RE-AIM framework were Reach (65%), Efficacy/Effectiveness (64%), and Adoption (64%), while Implementation (47%) and Maintenance (42%) were less often reported. The prevalence of reporting RE-AIM construct indicators ranged greatly, from 1% to 100%. This systematic review underscores the need for more focus on external validity to guide the development, implementation, and dissemination of future pediatric obesity interventions based in primary care settings. It also suggests conducting additional research on sustainable financing for pediatric obesity interventions.
An integrated approach for early in vitro seizure prediction utilizing hiPSC neurons and human ion channel assays
Authors: Rockley Kimberly , Roberts Ruth , Jennings Hannah , Jones Karen , Davis Myrtle , Levesque Paul , Morton Michael 
Published: August 2023

Abstract
Seizure liability remains a significant cause of attrition throughout drug development. Advances in stem cell biology coupled with an increased understanding of the role of ion channels in seizure offer an opportunity for a new paradigm in screening. We assessed the activity of 15 pro-seizurogenic compounds (7 CNS active therapies, 4 GABA receptor antagonists, and 4 other reported seizurogenic compounds) using automated electrophysiology against a panel of 14 ion channels (Nav1.1, Nav1.2, Nav1.6, Kv7.2/7.3, Kv7.3/7.5, Kv1.1, Kv4.2, KCa4.1, Kv2.1, Kv3.1, KCa1.1, GABA α1β2γ2, nicotinic α4β2, NMDA 1/2A). These were selected based on linkage to seizure in genetic/pharmacological studies. Fourteen compounds demonstrated at least one “hit” against the seizure panel and 11 compounds inhibited 2 or more ion channels. Next, we assessed the impact of the 15 compounds on electrical signaling using human-induced pluripotent stem cell neurons in microelectrode array (MEA). The CNS active therapies (amoxapine, bupropion, chlorpromazine, clozapine, diphenhydramine, paroxetine, quetiapine) all caused characteristic changes to electrical activity in key parameters indicative of seizure such as network burst frequency and duration. The GABA antagonist picrotoxin increased all parameters, but the antibiotics amoxicillin and enoxacin only showed minimal changes. Acetaminophen, included as a negative control, caused no changes in any of the parameters assessed. Overall, pro-seizurogenic compounds showed a distinct fingerprint in the ion channel/MEA panel. These studies highlight the potential utility of an integrated in vitro approach for early seizure prediction to provide mechanistic information and to support optimal drug design in early development, saving time and resources.
Carvedilol impairs bile acid homeostasis in mice: implication for nonalcoholic steatohepatitis
Authors: Lastuvkova Hana , Nova Zuzana , Hroch Milos , Alaei Faradonbeh Fatemeh , Schreiberova Jolana , Mokry Jaroslav , Faistova Hana , Stefela Alzbeta , Dusek Jan , Kucera Otto , Hyspler Radomír , Dohnalkova Ester , Bayer Rachel L , Hirsova Petra , Pavek Petr , Micuda Stanislav 
Published: August 2023

Abstract
Carvedilol is a widely used beta-adrenoreceptor antagonist for multiple cardiovascular indications; however, it may induce cholestasis in patients, but the mechanism for this effect is unclear. Carvedilol also prevents the development of various forms of experimental liver injury, but its effect on nonalcoholic steatohepatitis (NASH) is largely unknown. In this study, we determined the effect of carvedilol (10 mg/kg/day p.o.) on bile formation and bile acid (BA) turnover in male C57BL/6 mice consuming either a chow diet or a western-type NASH-inducing diet. BAs were profiled by liquid chromatography-mass spectrometry and BA-related enzymes, transporters, and regulators were evaluated by western blot analysis and qRT-PCR. In chow diet-fed mice, carvedilol increased plasma concentrations of BAs resulting from reduced BA uptake to hepatocytes via Ntcp transporter downregulation. Inhibition of the β-adrenoreceptor-cAMP-Epac1-Ntcp pathway by carvedilol may be the post-transcriptional mechanism underlying this effect. In contrast, carvedilol did not worsen the deterioration of BA homeostasis accompanying NASH; however, it shifted the spectra of BAs toward more hydrophilic and less toxic α-muricholic and hyocholic acids. This positive effect of carvedilol was associated with a significant attenuation of liver steatosis, inflammation, and fibrosis in NASH mice. In conclusion, our results indicate that carvedilol may increase BAs in plasma by modifying their liver transport. In addition, carvedilol provided significant hepatoprotection in a NASH murine model without worsening BA accumulation. These data suggest beneficial effects of carvedilol in patients at high risk for developing NASH.
CD30 in Cutaneous Pathology
Authors: Fernandez-Flores Angel , Cassarino David 
Published: August 2023

Abstract:
The discovery of CD30 as a diagnostic marker was essential in the identification of not only some lymphomas but also many other solid tumors and benign reactive conditions. Many CD30+ cutaneous disorders and tumors have been categorized since the identification of the marker. With the design of targeted therapies against CD30+ tumoral cells, the interest in CD30 determination was not only diagnostic but also mainly therapeutic. In this article, we explore the historical aspects of the discovery of CD30 and examine the main CD30-related cutaneous pathology, susceptible of anti-CD30 modern treatments.