bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cluster Analysis Using Principal Component Analysis Method and K-Means to Find Out the Compliance Group of Property Tax
Authors: Pramudita Rully , Rahaningsih Nining , Arum Sekar Puspita , Putri Medina Aprilia , Piseth Sok 
Published: April 2023

Abstract

The village of Kendal has experienced a decline in local income due to the high rate of property tax arrears, with 226 taxpayers (19% of residents) known to have outstanding payments. Additionally, with 1,159 separate residents residing in 10 block areas with varying tax amounts, it has become increasingly difficult for the Village Apparatus to profile taxpayers based on their characteristics. To overcome these problems, a data analysis model based on Machine Learning technology will be developed using the Principal Component Analysis (PCA) Method combined with the K-Means method. The objective of this study is to create a cluster analysis model that can accurately map the characteristics of taxpayers, making it easier for the Village Apparatus to identify and assist residents who need to pay their property tax. This proposed solution will also simplify the reporting process to the central government regarding the estimated regional revenue sourced from property tax.
Pengaruh Senam Aerobik Dan Senam Kebugaran Jasmani Terhadap Kualitas Tidur Lansia
Authors: Sonhaji Sonhaji , Adinatha Ni Nyoman M , Rifwandini Septiana Arsi 
Published: April 2023

ABSTRAK
Latar belakang : Menurut WHO kurang lebih 18% penduduk dunia mengalami gangguan sulit tidur dan meningkat setiap tahunnya. Terdapat 33 orang yang mengatakan sulit tidur atau terbangun dimalam hari, jumlah tidur setiap harinya kurang lebih 3-4 jam perhari. Senam lansia merupakan salah satu contoh aktivitas fisik yang direkomendasikan oleh WHO untuk memperbaiki kualitas tidur lansia. Tujuan : Mengetahui pengaruh senam aerobik dan senam kebugaran jasmani terhadap kualitas tidur lansia. Metode : Jenis penelitian dengan desain Quasi Eksperimental. Sampel penelitian adalah 30 responden dengan teknik total sampling. Pengukuran kualitas tidur menggunakan kuesioner Pittsburgh Sleep Quality Index (PSQI). Distribusi data diuji normalitasnya dengan uji Saphiro-Wilk. Uji hipotesis menggunakan uji Mann-Whitney untuk membandingkan pengaruh senam aerobik dan senam kebugaran jasmani terhadap kualitas tidur lansia. Hasil : Rerata nilai kualitas tidur sesudah senam aerobik sebesar 7.93, sedangkan rerata nilai kualitas tidur sesudah senam kebugara jasmani sebesar 9.67. Hasil uji statistik menunjukkan bahwa perbedaan tersebut bermakna (p = 0.024 < 0.05) Kesimpulan : Ada pengaruh senam aerobik terhadap kualitas tidur dibandingkan dengan senam kebugaran jasmani.
Aplikasi Terapi Dzikir Untuk Menurunkan Kecemasan Pada Pasien Hipertensi di Ruang Penyakit Dalam RSUD Kardinah Kota Tegal
Authors: Nugroho Santoso Tri , Prastiwi Dani , Apriliani Ristiana Putri 
Published: April 2023

Sampai saat ini, Hipertensi masih menjadi masalah kesehatan global dengan angka morbiditas dan mortalitas yang tinggi. Hipertensi akan semakin diperparah dengan perasaan cemas yang dialami oleh penderitanya. Diperlukan adanya suatu intervensi yang efektif untuk menurunkan kecemasan pada pasien Hipertensi. Dari penelitian ini adalah untuk mengetahui pengaruh terapi dzikir terhadap kecemasan pada pasien Hipertensi yang dirawat di RSUD Kardinah Kota Tegal. Penelitian ini berjenis Quasy experiment dengan pre test dan post test with control grup design. Dua puluh orang responden terbagi menjadi kelompok perlakuan dan kelompok kontrol dengan masing-masing 10 responden. Alat ukur yang digunakan adalah DASS 42. Analisis data menggunakan pair t test untuk mengetahui perbedaan rerata kecemasan pasien sebelum dan sesudah perlakuan pada kelompok intervensi dan wilcoxon pada kelompok kontrol. Untuk mengetahui signifikansi perbedaan rerata antara kelompok perlakuan dan kontrol menggunakan uji Mann Whitney. Rerata Kecemasan pada kelompok Intervensi sebelum diberikan terapi dzikir 18.90 dan sesudah diberikan terapi dzikir 10.40, dengan penurunan sebesar 8,5 dan p value: 0,016. Pada kelompok kontrol rerata pretest 16.30 dan posttest 13.10, dengan penurunan sebesar 3,6 dan p value: 0,731. Uji Mann Whitney menunjukkan ada perbedaan rerata signifikan antara kelompok perlakuan dengan kelompok kontrol, dengan p value: 0,00. Terapi Dzikir Berpengaruh Secara Signifikan Untuk Menurunkan Kecemasan Pasien Hipertensi di Ruang Penyakit dalam RSUD kardinah Kota Tegal.
Using a smartphone app in the measurement of posture-related pupil center shift on centration during corneal refractive surgery
Authors: Cheng Wenbo , Li Li , Luo Gang , Wang Yan 
Published: April 2023

Purpose: Pupil center is an important anchor point in corneal refractive surgery, which may affect by body position. This study investigated the feasibility of using a smartphone application in measurement of posture-related pupil center shifts.Methods: Images of undilated eyes were captured for 25 participants (age: 18–38 years) at a distance of 40 cm in four body positions (seated, supine, right lateral, and left lateral) under controlled lighting conditions. During taking images, a smartphone application was used to guide positioning without head rotation and tilt. From the images, the location of the pupil center and pupil diameter with respect to the limbus boundary were measured.Results: According to the data obtained by the smartphone application, pupil center was located slightly nasal and superior to the limbus center in the seated position, and it shifted more nasally and superiorly (p &lt; 0.001, OD 0.54 ± 0.11 mm, OS 0.57 ± 0.14 mm) in the supine position. When body position switched between left and right lateral positions, the pupil centers of both eyes shifted along the direction of gravity (p &lt; 0.05), and no significant shift occurred along the longitudinal axis. Moreover, pupil constriction was observed when the body position changed from seated to supine position (p &lt; 0.001, OD 0.64 ± 0.57 mm, OS 0.63 ± 0.58 mm).Conclusion: Posture-related pupil center shift may be larger than the error tolerance of centration in corneal refractive surgery, which might be difficult to measure by the existing instruments. An accessible application is necessary for evaluating the shift of pupil center and guiding centration during the surgery.
Strontium-doped chromium oxide for RhB reduction and antibacterial activity with evidence of molecular docking analysis
Authors: Ikram Muhammad , Shahzadi Anum , Bilal Muhammad , Haider Ali , Ul-Hamid Anwar , Nabgan Walid , Haider Junaid , Ali Salamat , Medina Francisco , Imran Muhammad 
Published: April 2023

The emergence of multi-drug resistance (MDR) in aquatic pathogens and the presence of cationic dyes are the leading causes of water contamination on a global scale. In this context, nanotechnology holds immense promise for utilizing various nanomaterials with catalytic and antibacterial properties. This study aimed to evaluate the catalytic and bactericidal potential of undoped and Sr-doped Cr2O3 nanostructures (NSs) synthesized through the co-precipitation method. In addition, the morphological, optical, and structural properties of the resultant NSs were also examined. The optical bandgap energy of Cr2O3 has been substantially reduced by Sr doping, as confirmed through extracted values from absorption spectra recorded by UV-Vis studies. The field-emission scanning electron microscopy (FE-SEM) and transmission electron microscopy (TEM) micrographs illustrate that the composition of Cr2O3 primarily consisted of agglomerated, irregularly shaped NSs with a morphology resembling nanoflakes. Moreover, the presence of Sr in the lattice of Cr2O3 increased the roughness of the resulting NSs. The catalytic activity of synthesized NSs was analyzed by their reduction ability of Rhodamine B (RhB) dye in the dark under different pH conditions. Their antibacterial activity was evaluated against MDR Escherichia coli (E. coli). Sr doping increased antibacterial efficiency against MDR E. coli, as indicated by inhibition zone measurements of 10.15 and 11.75 mm at low and high doses, respectively. Furthermore, a molecular docking analysis was conducted to determine the binding interaction pattern between NSs and active sites in the target cell protein. The findings corroborated antimicrobial test results indicating that Sr-Cr2O3 is the most effective inhibitor of FabH and DHFR enzymes.
Possible role of tidal and rotational forcing on bradyseismic crises and volcanic unrest in the Campi Flegrei and Somma-Vesuvius areas
Authors: Lambert S. , Sottili G. 
Published: April 2023

Volcanic unrest at large calderas, led by the complex interaction between the degassing of the shallow magma reservoir and the overlying hydrothermal system, occurs at intervals of 10–100 years. Even if only a minority of bradyseismic crises ends with an eruption, discriminating between pre-eruptive and non-eruptive signals is fundamental for defining levels of alert. Our study explores the possible link between recent episodes of major unrest at the Campi Flegrei caldera, located in the densely inhabited area near the city of Naples (Italy), and the astronomical forcing arising from both lunisolar tides and Earth’s rotation. We analyze seismic data at Mount Vesuvius and Campi Flegrei sites and find significant correlation between the multiyear variation of the seismic energy and the tidal part of the strain, whereas the correlation with the rotational part from polar motion and length-of-day variations is more elusive. The near-zero time-lag between strain and seismicity suggests a rapid response of the seismicity to the excitation. We discuss how our findings are line with previous works evidencing how the decompression of the low-viscosity, mafic magma reservoir results in a rapid release of dissolved volatiles which in turn produces an abrupt acceleration in the Campi Flegrei caldera geochemical and geophysical signals.
A-SATMVSNet: An attention-aware multi-view stereo matching network based on satellite imagery
Authors: Lin Li , Zhang Yuanben , Wang Zongji , Zhang Lili , Liu Xiongfei , Wang Qianqian 
Published: April 2023

Introduction: The stereo matching technology of satellite imagery is an important way to reconstruct real world. Most stereo matching technologies for satellite imagery are based on depth learning. However, the existing depth learning based methods have the problems of holes and matching errors in stereo matching tasks.Methods: In order to improve the effect of satellite image stereo matching results, we propose a satellite image stereo matching network based on attention mechanism (A-SATMVSNet). To solve the problem of insufficient extraction of surface features, a new feature extraction module based on triple dilated convolution with attention module is proposed, which solves the problem of matching holes caused by insufficient extraction of surface features. At the same time, compared with the traditional weighted average method, we design a novel cost-volume method that integrates attention mechanism to reduce the impact of matching errors to improve the accuracy of matching.Results and discussion: Experiments on public multi-view stereo matching dataset based on satellite imagery demonstrate that the proposed method significantly improves the accuracy and outperforms various previous methods. Our source code is available at https://github.com/MVSer/A-SATMVSNet.
Intra-arterial verapamil improves functional outcomes of thrombectomy in a preclinical model of extended hyperglycemic stroke
Authors: Nasoohi Sanaz , Alehossein Parsa , Jorjani Masoumeh , Brown Candice M. , Ishrat Tauheed 
Published: April 2023

The abrupt hyperglycemic reperfusion following thrombectomy has been shown to harm the efficacy of the intervention in stroke patients with large vessel occlusion. Studies of ours and others have shown thioredoxin-interacting protein (TXNIP) is critically involved in hyperglycemic stroke injury. We recently found verapamil ameliorates cerebrovascular toxicity of tissue plasminogen activators in hyperglycemic stroke. The present study aims to answer if verapamil exerts direct neuroprotective effects and alleviates glucose toxicity following thrombectomy in a preclinical model of hyperglycemic stroke. Primary cortical neural (PCN) cultures were exposed to hyperglycemic reperfusion following oxygen-glucose deprivation (OGD), with or without verapamil treatment. In a mouse model of intraluminal stroke, animals were subjected to 4 h middle cerebral artery occlusion (MCAO) and intravenous glucose infusion. Glucose infusion lasted one more hour at reperfusion, along with intra-arterial (i.a.) verapamil infusion. Animals were subjected to sensorimotor function tests and histological analysis of microglial phenotype at 72 h post-stroke. According to our findings, glucose concentrations (2.5–20 mM) directly correlated with TXNIP expression in OGD-exposed PCN cultures. Verapamil (100 nM) effectively improved PCN cell neurite growth and reduced TXNIP expression as well as interaction with NOD-like receptor pyrin domain-containing-3 (NLRP3) inflammasome, as determined by immunoblotting and immunoprecipitation. In our mouse model of extended hyperglycemic MCAO, i.a. verapamil (0.5 mg/kg) could attenuate neurological deficits induced by hyperglycemic stroke. This was associated with reduced microglial pro-inflammatory transition. This finding encourages pertinent studies in hyperglycemic patients undergoing thrombectomy where the robust reperfusion may exacerbate glucose toxicity.
Unravelling the allosteric binding mode of αD-VxXXB at nicotinic acetylcholine receptors
Authors: Ho Thao NT , Abraham Nikita , Lewis Richard J. 
Published: April 2023

αD-conotoxins are 11 kDa homodimers that potently inhibit nicotinic acetylcholine receptors (nAChRs) through a non-competitive (allosteric) mechanism. In this study, we describe the allosteric binding mode of the granulin-like C-terminal (CTD) of VxXXB bound to Lymnea stagnalis acetylcholine binding protein (Ls-AChBP), a soluble homologue of the extracellular ligand-binding domain of nAChRs. This co-crystal complex revealed a novel allosteric binding site for nAChR antagonists outside the C-loop that caps the orthosteric site defined by the nAChR agonist nicotine and the antagonist epibatidine. Mutational and docking studies on Ls-AChBP supported a two-site binding mode for full-length VxXXB, with the first CTD binding site located outside the C-loop as seen in the co-crystal complex, with a second CTD binding site located near the N-terminal end of the adjacent subunit of AChBP. These results provide new structural insight into a novel allosteric mechanism of nAChR inhibition and define the cooperative binding mode of the N-terminal domain linked granulin core domains of αD-conotoxins.
A system theory based digital model for predicting the cumulative fluid balance course in intensive care patients
Authors: Polz Mathias , Bergmoser Katharina , Horn Martin , Schörghuber Michael , Lozanović Jasmina , Rienmüller Theresa , Baumgartner Christian 
Published: April 2023

Background: Surgical interventions can cause severe fluid imbalances in patients undergoing cardiac surgery, affecting length of hospital stay and survival. Therefore, appropriate management of daily fluid goals is a key element of postoperative intensive care in these patients. Because fluid balance is influenced by a complex interplay of patient-, surgery- and intensive care unit (ICU)-specific factors, fluid prediction is difficult and often inaccurate.Methods: A novel system theory based digital model for cumulative fluid balance (CFB) prediction is presented using recorded patient fluid data as the sole parameter source by applying the concept of a transfer function. Using a retrospective dataset of n = 618 cardiac intensive care patients, patient-individual models were created and evaluated. RMSE analyses and error calculations were performed for reasonable combinations of model estimation periods and clinically relevant prediction horizons for CFB.Results: Our models have shown that a clinically relevant time horizon for CFB prediction with the combination of 48 h estimation time and 8–16 h prediction time achieves high accuracy. With an 8-h prediction time, nearly 50% of CFB predictions are within ±0.5 L, and 77% are still within the clinically acceptable range of ±1.0 L.Conclusion: Our study has provided a promising proof of principle and may form the basis for further efforts in the development of computational models for fluid prediction that do not require large datasets for training and validation, as is the case with machine learning or AI-based models. The adaptive transfer function approach allows estimation of CFB course on a dynamically changing patient fluid balance system by simulating the response to the current fluid management regime, providing a useful digital tool for clinicians in daily intensive care.
Trajectories of Healthcare Utilization Among Children and Adolescents With Autism Spectrum Disorder and/or Attention-Deficit/Hyperactivity Disorder in Japan
Authors: Aoki Ai , Niimura Michi , Kato Tsuguhiko , Takehara Kenji , Iida Junzo , Okada Takashi , Kurokami Tsunehiko , Nishimaki Kengo , Ogura Kaeko , Okuno Masakage , Koeda Tatsuya , Igarashi Takashi ,   The Collaborative Working Group
Published: April 2023

BackgroundEarly intervention and prevention of psychiatric comorbidities of children with autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD) are urgent issues. However, the differences in the diagnoses of ASD and ADHD and psychiatric comorbidities associated with age, long-term healthcare utilization trajectories, and its associated diagnostic features have not been fully elucidated in Japan.MethodWe conducted a retrospective observational study using the medical records. Member hospitals of three major consortiums of hospitals providing child and adolescent psychiatric services in Japan were recruited for the study. Children who accessed the psychiatry services of the participating hospitals in April 2015 were followed up for 5 years, and data on their clinical diagnoses, consultation numbers, and hospitalizations were collected. Non-hierarchical clustering was performed using two 10-timepoint longitudinal variables: consultation numbers and hospitalization. Among the major clusters, the differences in the prevalence of ASD, ADHD, comorbid intellectual disability, neurotic disorders, and other psychiatric disorders were assessed.ResultsA total of 44 facilities participated in the study (59.5%), and 1,003 participants were enrolled. Among them, 591 diagnosed with ASD and/or ADHD (58.9%) and 589 without missing data were assessed. The mean age was 10.1 years, and 363 (70.9%) were boys. Compared with the pre-schoolers, the school-aged children and adolescents had fewer ASD, more ADHD, and fewer comorbid intellectual disability diagnoses, as well as more diagnoses of other psychiatric disorders. A total of 309 participants (54.7%) continued consultation for 2 years, and 207 (35.1%) continued for 5 years. Clustering analysis identified three, two, and three major clusters among pre-schoolers, school-aged children, and adolescents, respectively. The largest cluster was characterized by early termination of the consultation and accounted for 55.4, 70.6, and 73.4% of pre-schoolers, school-aged children, and adolescents, respectively. Among the school-aged children, the diagnosis of ADHD was associated with a cluster that required longer periods of consultations. Among the adolescents, comorbid psychiatric disorders other than intellectual disability and neurotic disorders were associated with clusters that required hospitalization.ConclusionContinuous healthcare needs were common and psychiatric comorbidities were associated with complex trajectory among adolescents. The promotion of early intervention and prevention of comorbidities are important.
Rethinking children’s physical activity interventions at school: A new context-specific approach
Authors: Jago Russell , Salway Ruth , House Danielle , Beets Michael , Lubans David Revalds , Woods Catherine , de Vocht Frank 
Published: April 2023

Physical activity is important for children’s health. However, evidence suggests that many children and adults do not meet international physical activity recommendations. Current school-based interventions have had limited effect on physical activity and alternative approaches are needed. Context, which includes school setting, ethos, staff, and sociodemographic factors, is a key and largely ignored contributing factor to school-based physical activity intervention effectiveness, impacting in several interacting ways.ConceptualizationCurrent programs focus on tightly-constructed content that ignores the context in which the program will be delivered, thereby limiting effectiveness. We propose a move away from uniform interventions that maximize internal validity toward a flexible approach that enables schools to tailor content to their specific context.Evaluation designsEvaluation of context-specific interventions should explicitly consider context. This is challenging in cluster randomized controlled trial designs. Thus, alternative designs such as natural experiment and stepped-wedge designs warrant further consideration.Primary outcomeA collective focus on average minutes of moderate-to-vigorous intensity physical activity may not always be the most appropriate choice. A wider range of outcomes may improve children’s physical activity and health in the long-term. In this paper, we argue that greater consideration of school context is key in the design and analysis of school-based physical activity interventions and may help overcome existing limitations in the design of effective interventions and thus progress the field. While this focus on context-specific interventions and evaluation is untested, we hope to stimulate debate of the key issues to improve future physical activity intervention development and implementation.