bluuebunny/crossref_metadata_2025_split huggingface dataset:
Traditional medicinal plants in the treatment of gastrointestinal parasites in humans: A systematic review and meta‐analysis of clinical and experimental evidence
Authors: Ranasinghe Sandamalie , Aspinall Sasha , Beynon Amber , Ash Amanda , Lymbery Alan 
Published: May 2023

AbstractGastrointestinal (GI) parasites cause significant morbidity and mortality worldwide. The use of conventional antiparasitic drugs is often inhibited due to limited availability, side effects or parasite resistance. Medicinal plants can be used as alternatives or adjuncts to current antiparasitic therapies. This systematic review and meta‐analysis aimed to critically synthesise the literature on the efficacy of different plants and plant compounds against common human GI parasites and their toxicity profiles. Searches were conducted from inception to September 2021. Of 5393 screened articles, 162 were included in the qualitative synthesis (159 experimental studies and three randomised control trials [RCTs]), and three articles were included in meta‐analyses. A total of 507 plant species belonging to 126 families were tested against different parasites, and most of these (78.4%) evaluated antiparasitic efficacy in vitro. A total of 91 plant species and 34 compounds were reported as having significant in vitro efficacy against parasites. Only a few plants (n = 57) were evaluated for their toxicity before testing their antiparasitic effects. The meta‐analyses revealed strong evidence of the effectiveness of Lepidium virginicum L. against Entamoeba histolytica with a pooled mean IC50 of 198.63 μg/mL (95% CI 155.54–241.72). We present summary tables and various recommendations to direct future research.
TG‐compound optimal design for bivariate binary responses modelled via Copulas
Authors: Kilany Neveen Mohamed 
Published: May 2023

AbstractUnivariate data has been the focus of optimal design for generalized linear models. It is common practice to conduct experiments with multiple dependent responses that are modelled using regression techniques. To design the experiment for all these responses, one needs a multivariate distribution supporting a previously chosen data model. The T‐optimal criterion is used to discriminate between two competing models. The designs that are optimal for discrimination between two models may be unsuitable for describe the quality of predictions for test data. G‐optimal criterion overcomes this restriction by minimizing the maximum variance of the predicted values. The design of experiments with dependent bivariate binary data is a topic we discuss in this paper. For dependent bivariate binary data, a technique for deriving TG‐optimal experimental designs using Copula is shown. The new compound TG‐criterion satisfy the dual aim to selecting the true model and minimizing the maximum prediction variance. The equivalence theorem is demonstrated and proved for the new compound criterion. A numerical example is presented to show the properties of the new compound criterion for bivariate binary setting and its value in meeting the dual aims.
A case of eosinophilic pneumonia induced by lettuce
Authors: Sekiya Reina , Nagano Tatsuya , Moriyama Tatsuya , Kawaguchi Aki , Fukui Takafumi , Mimura Chihiro , Kimura Yohei , Ohnishi Hisashi , Kotani Yoshikazu , Nishimura Yoshihiro 
Published: May 2023

AbstractA 56‐year‐old female lettuce farmer was admitted to the hospital with a low‐grade fever, worsening cough, and dyspnoea. A blood test revealed eosinophilia and a high serum IgE concentration. The 3‐year follow‐up showed that her total IgE level increased in December, peaked in May, and suddenly decreased in August. This result was consistent with the lettuce harvest season. A chest x‐ray taken on admission showed an infiltrative shadow in the upper lung field. Chest CT revealed patchy ground glass opacity on the upper lung field and thickening of the bronchial wall. The bronchoalveolar lavage fluid contained 8% eosinophils. She was treated with prednisolone, and her symptoms and radiological findings improved. The 37 kDa protein that reacted with the patient's sera was identified by immunoblot analysis.
How do different functional crop groups perform in temperate silvoarable agroforestry systems? A Swiss case study
Authors: den Hond‐Vaccaro Christina , Six Johan , Schöb Christian 
Published: May 2023

AbstractIntroductionAgroforestry systems provide a number of ecosystem services and are frequently considered as a promising diversification strategy for more sustainable and climate resilient primary production. However, most agroforestry field trials compare only one crop type with a control in open field. Additional comparisons between treatments that influence nutrient and water availability are often not looked at, nor are comparisons between crop species.Materials and MethodsTo deepen our understanding of the ecological processes underlying the potential benefits of agroforestry for food production, the present experimental study addresses three environmental factors (shade, fertilisation and irrigation) on three functionally different crop species (field bean, summer barley, summer rapeseed) and a C4‐grass (Echinochloa crus‐galli) in a Swiss agroforestry system. Crop performance (physiological traits, yield) between functional groups was analysed among treatment combinations of shade, fertilisation and irrigation. Physiological traits included measurements of chlorophyll content, stomatal conductance, specific leaf area and plant height.ResultsSummer barley and field bean showed significant yield declines when shaded (−44% and −38%, respectively), similar to summer rapeseed with a significant biomass decline (−35%). Shade significantly increased the occurrence of lodging in barley. Rapeseed in particular performed better when fertilised (+40% biomass).ConclusionThe results allow to estimate the range of potential yield losses in the competitive zone near mature trees for functionally different crop groups. The findings serve as a decision‐support for species selection in temperate European agroforestry systems.
Amine Functionalized Magnetite GO‐MWCNT as an Efficient 3D Hybrid Aerogel for the Remediation of Copper(II) from Wastewater: Box‐Behnken Design Optimization
Authors: Islam Aminul , Fatima Sana 
Published: May 2023

AbstractThis work focuses on the sequestration of Cu(II) from aqueous environment owing to the risks posed to human health. A magnetic hybrid aerogel (mGO‐TETA‐MWCNT) was synthesized by one‐pot self‐assembly of magnetic graphene oxide (mGO) and multiwalled carbon‐nanotubes (MWCNT) post functionalization with triethylenetetramine (TETA) through hydrothermal reduction. The prepared adsorbent was characterized and employed for efficient removal of Cu(II). The aerogel, mGO‐TETA‐MWCNT presented maximum adsorption capacity (Qmax) of 232.22 mg g−1 at Box‐Behnken design optimized conditions: pH 5.6, time 36.7 min, and concentration 999.7 mg L−1. The Brouers‐Sotolongo (BS) isotherm and Fractal‐like pseudo‐second‐order (FLPSO) kinetic model fitted best representing heterogeneity of the hybrid adsorbent. The presence of interferent metal ions(Ni(II), Pb(II), Cd(II), Zn(II)) showed negligible effect on the selective sorption of Cu(II). The prepared adsorbent could be regenerated upto five cycles (>95 % removal) when eluted using 0.5 m HCl. The aerogel was successfully utilized to remove Cu(II) from wastewater, river‐water, and groundwater.
Insights into the Origin and Therapeutic Implications of Benzopyran and Its Derivatives
Authors: Tiwari Ajay Kumar , Singh Man Vir 
Published: May 2023

AbstractBenzopyran derivatives are essential for life and are found abundantly in nature. Benzopyran compounds and their derivatives play an essential role in medicinal chemistry. The alkaloids, flavonoids, tocopherols, and anthocyanins natural products comprise benzopyran's basic structure. Various benzopyran derivatives have been used for therapeutic effects. Benzopyran derivatives can be proficient in various pharmaceutical applications for cellular markers. The basic structure of benzopyran is an efficient class of synthetic products and an emerging attention area of research. Therefore, impactful information on benzopyran and its derivatives has been compiled in the last several years. Recently, the development of novel benzopyran and its applications are contributing to medicines and pharmacy.
Syntheses, Structural Characterization, Optical and Magnetic Properties of a New Polyoxovanadate‐Based Metal‐Organic Polyhedron
Authors: Nguyen My Van , Tran Truong Quang 
Published: May 2023

AbstractA new polyoxovanadate‐based metal‐organic polyhedron, termed V‐MOP‐19, constructed from pentanuclear {V5O9Cl} clusters and 1,4‐naphthalenedicarboxylic acid linkers, was successfully fabricated via the solvothermal method. Structural analysis revealed that V‐MOP‐19 adopts the cubic symmetry featured with an octahedral pore cage of 15.7 Å. Full characterization of V‐MOP‐19 was measured by Fourier transform infrared (FT‐IR), Raman spectroscopy, powder X‐ray diffraction (PXRD), scanning electron microscopy (SEM), energy‐dispersive X‐ray (EDX), transmission electron microscopy (TEM), thermogravimetric and differential scanning calorimetry analysis (TGA‐DSC), N2 sorption isotherm and elemental analysis (EA). The band gap energy of V‐MOP‐19, measured by UV‐Vis diffuse reflectance spectroscopy (UV‐Vis/DRS), is determined to be 2.38 eV. Moreover, the cyclic voltammetry investigation confirms a high correspondence of the band gap value (2.41 eV) with the mentioned UV‐Vis/DRS study. In particular, V‐MOP‐19 exhibits a unique magnetic property with remarkable coercivity and remanent magnetization value. These findings demonstrate that V‐MOP‐19 could be used as a potential candidate in further photocatalytic and magnetic investigations.
Synthesis and Tunable Fluorescence of N,N‐Disubstitute ortho‐Aminostyryl D‐π‐A Chromophores Based on a Hydroxytricyanopyrrole (HTCP) Acceptor
Authors: Fedoseev Sergey V. , Yu. Belikov Mikhail 
Published: May 2023

AbstractThe first representatives of a new group of fluorescent donor‐acceptor chromophores, the key structural fragments of which are an easily modifiable hydroxytricyanopyrrole (HTCP) acceptor and an N,N‐disubstituted ortho‐aminostyryl donor fragment, were synthesized. By changing the substituent on both the donor and acceptor fragments, the possibility of varying the emission maxima in the solid state in the red region in the range of 620–732 nm was achieved. It was shown that the introduction of an alkoxy group into the pyrrole ring of HTCP leads to an increase in the quantum yield (Φc) of solid state emission to 9.5 %. In the liquid phase HTCP‐chromophores fluoresce in the range of 621–639 nm with a relative quantum yield of up to 5.5 % The energy values found for the band gap of HTCP chromophore with ortho‐morpholinostyryl donor fragment were in the range of 2.38–2.41 eV.
A Practical Synthesis of 2‐Arylimino‐2H‐Chromenes via Biocatalytic System in Water
Authors: Ma Jinglin , Li Fengxi , Xu Yuelin , Wang Chunyu , Du Chuang , Wang Zhi , Wang Lei 
Published: May 2023

AbstractA metal‐free, straightforward, non‐hazardous reagent‐added, one‐pot approach for the efficient synthesis of 2‐arylimino‐2H‐chromenes with high yields was developed for the first time in this report through the coupling of salicylaldehydes with β‐ketothioamides, which was catalyzed by lipase in water. This green strategy provides an efficient method to obtain various 2‐arylimino‐2H‐chromenes and enriches the practical application of biocatalysis.
Development of Single Molecule Techniques for Sensing and Manipulation of CRISPR and Polymerase Enzymes
Authors: Chu Josephine , Romero Andres , Taulbee Jeffrey , Aran Kiana 
Published: May 2023

AbstractClustered regularly interspaced short palindromic repeats (CRISPR) and polymerases are powerful enzymes and their diverse applications in genomics, proteomics, and transcriptomics have revolutionized the biotechnology industry today. CRISPR has been widely adopted for genomic editing applications and Polymerases can efficiently amplify genomic transcripts via polymerase chain reaction (PCR). Further investigations into these enzymes can reveal specific details about their mechanisms that greatly expand their use. Single‐molecule techniques are an effective way to probe enzymatic mechanisms because they may resolve intermediary conformations and states with greater detail than ensemble or bulk biosensing techniques. This review discusses various techniques for sensing and manipulation of single biomolecules that can help facilitate and expedite these discoveries. Each platform is categorized as optical, mechanical, or electronic. The methods, operating principles, outputs, and utility of each technique are briefly introduced, followed by a discussion of their applications to monitor and control CRISPR and Polymerases at the single molecule level, and closing with a brief overview of their limitations and future prospects.
Blast resistance of single steel‐concrete composite slabs under contact explosion
Authors: Zhao Chunfeng , Chen Yingjie , Jin Qiang , Wang Jingfeng , Li Xiaojie 
Published: May 2023

AbstractTerrorist attacks or contact explosions could trigger severe damage to structural components or even cause the local or global collapse of the structure in civil engineering and infrastructures. Single‐steel‐concrete (SSC) slabs consist of a concrete core and one steel faceplate combined with shear studs or tie bars that can be applied in resisting explosion or blast load. This paper experimentally and numerically studies the blast performance of the scale SSC specimens under a contact explosion. The damage modes, deflections, and acceleration response of the SSC specimens are obtained and compared by experimental and numerical methods. And then the influences of the explosive, the shear stud length, and the steel plate thickness on the damage modes, acceleration, and displacement response are studied parametrically. It is observed that both of the concrete layers in SSC slabs have crater failure at the impacted surface and steel plates occur local deformation or buckling. No penetrability failure generates in the slabs because of the existence of the steel plate, which can improve the blast resistance and decrease the maximum deflections of the specimens. Finally, an empirical equation is developed to estimate the midspan displacement of the slab using the multivariable regression method (MNRM).
Development of creep and shrinkage prediction models for recycled aggregate concrete
Authors: Rabadia Komal , Aslani Farhad 
Published: May 2023

AbstractStudies have found utilization of recycled aggregate concrete (RAC) for engineering use to be environmentally favorable by preserving natural resources and limiting waste reduction. However, the use of RAC has not been effectively integrated in the industry due to limited research overlying the critical areas of its creep and shrinkage behavior. Hence, this study aims to investigate the natural aggregate concrete creep and shrinkage prediction models and perform recycled concrete aggregate (RCA) replacement level and water absorption modifications to illustrate the presence and behavior of RAC. Comparative analysis was undertaken by establishing comprehensive conventional concrete and RAC experimental databases and investigating several creep and shrinkage prediction models including, ACI 209R‐92, Bazant–Baweja B3, CEB MC 90, GL 2000, MC 2010, and JSCE 2010. The Bazant–Baweja B3 model was found to present the most optimal results by evaluating each conventional model against the RAC databases and performing regression analysis. Hence, the Bazant–Baweja B3 natural aggregate concrete models for creep and shrinkage were then effectively modified to illustrate the presence of RCA replacement level and water absorption. The adjusted models were verified with a set of experimental databases which successfully presented favourable results with coefficient of correlation factors increased from an average of 0.76 to 0.9.
Recent Advances and Future Perspectives of Lead‐Free Halide Perovskites for Photocatalytic CO2 Reduction
Authors: Qi Fei , Pu Yayun , Wu Daofu , Tang Xiaosheng , Huang Qiang 
Published: May 2023

AbstractIt is still challenging to design and develop the state‐of‐the‐art photocatalysts toward CO2 photoreduction. Enormous researchers have focused on the halide perovskites in the photocatalytic field for CO2 photoreduction, due to their excellent optical and physical properties. The toxicity of lead‐based halide perovskites prevents their large‐scale applications in photocatalytic fields. In consequence, lead‐free halide perovskites (LFHPs) without the toxicity become the promising alternatives in the photocatalytic application for CO2 photoreduction. In recent years, the rapid advances of LFHPs have offer new chances for the photocatalytic CO2 reduction of LFHPs. In this review, we summarize not only the structures and properties of A2BX6, A2B(I)B(III)X6, and A3B2X9‐type LFHPs but also their recent progresses on the photocatalytic CO2 reduction. Furthermore, we also point out the opportunities and perspectives to research LFHPs photocatalysts for CO2 photoreduction in the future.
CircKDM1B promotes hepatocellular carcinoma progression through regulating miR‐1322/PRC1 axis
Authors: Yi Mo , Lv Samei , He Yu , Wu Youwei , Zhang Jian , Chen Qian 
Published: May 2023

AbstractBackgroundCircular RNA (circRNA) is considered an important molecular marker for the early diagnosis of tumors and a potential therapeutic target. Herein, we investigated the role and regulatory mechanism of circKDM1B in hepatocellular carcinoma (HCC).MethodsThe expression of circKDM1B, miR‐1322 and Protein regulator of cytokinesis 1 (PRC1) mRNA were determined by quantitative real‐time polymerase chain reaction (qRT‐PCR). Cell counting kit‐8 (CCK8) and 5‐ethynyl‐2′‐deoxyuridine (EdU) staining assays were performed to assess cell proliferation activity. Cell migration and invasion were detected by wound‐healing scratch and transwell assay. Flow cytometry was used to analyze cell apoptosis. The protein levels of PCNA, MMP9, C‐caspase3 and PRC1 were examined using western blot. The binding of circKDM1B and miR‐1322 was verified by dual‐luciferase reporter assay, RNA immunoprecipitation (RIP) and RNA pull down assay.ResultsCircKDM1B was overexpressed in HCC tissues and cells, and its overexpression was related to tumor stage and poor prognosis of HCC patients. Functionally, knockdown of circKDM1B suppressed proliferation, migration, invasion and promoted apoptosis of HCC cells. Mechanistically, circKDM1B functioned as ceRNA of miR‐1322 to upregulate PRC1 in HCC cells. Overexpression of miR‐1322 inhibited proliferation, migration, invasion and facilitated apoptosis of HCC cells, which was partly reversed by PRC1 overexpression. CircKDM1B knockdown impeded HCC tumor growth in vivo.ConclusionCircKDM1B played a critical role in HCC progression by regulating cell proliferation, migration, invasion and apoptosis. CircKDM1B/miR‐1322/PRC1 axis might be a novel therapeutic target of HCC patients.
Inclusion of Vietnamese Americans: Opportunities to understand dementia disparities
Authors: Meyer Oanh L. , Park Van Ta , Kanaya Alka M. , Farias Sarah Tomaszewski , Hinton Ladson , Tiet Quyen Q. , Vuong Quyen , Nguyen Stephanie , Harvey Danielle , Whitmer Rachel A. 
Published: May 2023

AbstractThere is a dearth of research on cognitive aging and dementia in Asian Americans, particularly Vietnamese Americans, who are the fourth largest Asian subgroup in the United States. The National Institutes of Health is mandated to make certain that racially and ethnically diverse populations are included in clinical research. Despite the widespread recognition to ensure that research findings can be generalizable to all groups, there are no estimates of the prevalence or incidence of mild cognitive impairment and Alzheimer's disease and related dementias (ADRD) in Vietnamese Americans, nor do we understand ADRD risk and protective factors in this group. In this article, we posit that studying Vietnamese Americans contributes to a better understanding of ADRD in general and offers unique opportunities for elucidating life course and sociocultural factors that contribute to cognitive aging disparities. That is, the unique context of Vietnamese Americans may provide understanding in terms of within‐group heterogeneity and key factors in ADRD and cognitive aging. Here, we provide a brief history of Vietnamese American immigration and describe the large but often ignored heterogeneity of Asian Americans in the United States, elucidate how early life adversity and stress might influence late‐life cognitive aging, and provide a basis for the role of sociocultural and health factors in the study of Vietnamese cognitive aging disparities. Research with older Vietnamese Americans provides a unique and timely opportunity to more fully delineate the factors that contribute to ADRD disparities for all populations.
Performance of cocultivation of Chlorella vulgaris and four different fungi in biogas slurry purification and biogas upgrading by induction of strigolactone (GR24) and endophytic bacteria
Authors: Ji Yuan , Huang Luanbei , Wang Zhengfang , Xu Jie , Wei Jing , Zhao Yongjun 
Published: May 2023

AbstractThis study aimed to determine the best fungi to form the algal‐bacterial‐fungal symbionts and identify the optimal conditions for the synchronous processing of biogas slurry and biogas. Chlorella vulgaris (C. vulgaris) and endophytic bacteria (S395‐2) isolated from it, and four different fungi (Ganoderma lucidum, Pleurotus ostreatus, Pleurotus geesteranus, and Pleurotus corucopiae) were used to form different symbiotic systems. Four different concentrations of GR24 were added to systems to examine the growth characteristics, the content of chlorophyll a (CHL‐a), the activity of carbonic anhydrase (CA), the photosynthetic performance, the removal of nutrients, and the biogas purification performance. The results suggested that the growth rate, CA, CHL‐a content, and photosynthetic performance of the C. vulgaris‐endophytic bacteria‐Ganoderma lucidum symbionts were higher than the other three symbiotic systems when 10−9 M GR24 was added. The highest nutrients/CO2 removal efficiency 78.36 ± 6.98% for chemical oxygen demand (COD), 81.63 ± 7.35% for total nitrogen (TN), 84.05 ± 7.16% for total phosphorus (TP), and 65.18 ± 6.12% for CO2 was obtained under the above optimal conditions. This approach will provide a theoretical basis for the selection and optimization of the algal‐bacterial‐fungal symbionts for biogas slurry and biogas purification.Practitioner Points
Algae‐bacteria/fungal symbiont presents superior nutrients and CO2 removal capacities.
The maximum CO2 removal efficiency was 65.18 ± 6.12%.
The removal performance was affected by fungi type.