bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effects of macro‐algae supplementation on serum lipid, glycaemic control and anthropometric indices: A systematic review and meta‐analysis of clinical trials
Authors: Rezaei Shahla , Doaei Saeid , Tabrizi Reza , Ghobadi Saeed , Zare Morteza , Gholamalizadeh Maryam , Mazloom Zohreh 
Published: July 2023

AbstractIntroductionMacro‐algae products have been shown to ameliorate the metabolic disorders state. Thus, highlighting their function as supplementary therapeutic agents can be a novel strategy for clinical therapies. This systematic review and meta‐analysis of clinical trials aimed to summarize the effect of macro‐algae consumption on serum lipid profile, glycaemic control and anthropometric factors.MethodsIn this systematic review and meta‐analysis, a comprehensive search was performed for relevant studies published up to May 2023. The Cochran's Q test and I‐square (I2) tests were used to evaluate heterogeneity across the included studies. The meta‐analysis was conducted using random‐effects model (DerSimonian and Laird), and weighted mean difference (WMD) was considered as the pooled effect size.ResultsOut of 8602 papers in the initial screening, eight clinical trials with a total of 438 participants were included into this meta‐analysis. The results indicated that macro‐algae supplementation significantly decreased serum levels of total cholesterol (TC) (WMD = −6.7 mg/dL; 95% CI: −12.59, −0.80; item = 0.026) and low‐density lipoprotein cholesterol (LDL‐c) (WMD = −8.25 mg/dL; 95% CI: −15.38, −1.12; p‐value = .023). There was an increase in level of high‐density lipoprotein cholesterol (HDL‐c) (WMD = 0.48 mg/dL; 95% CI: −2.05, 3.01; p‐value = .71) which was not statistically significant. Macro‐algae supplementation reduced body mass index (BMI) (WMD = −0.28 kg/m2; 95% CI: −0.96, 0.41; p‐value = .426), weight (WMD = −0.39 kg; 95% CI: −3.6, 2.83; p‐value = .81), waist circumference (WC) (WMD = −0.52 cm; 95% CI: −2.71, 1.66; p‐value = .64), fasting blood sugar (FBS) (WMD = −1.95 mg/dL; 95% CI: −5.19, 1.28; p‐value = .24) and HbA1c (WMD = −0.02%; 95% CI: −0.14, 0.09; p‐value = .66) in intervention group.ConclusionsThis meta‐analysis indicated that macro‐algae supplementation significantly decreased TC and LDL‐c level. It can also increase HDL‐c level and reduce anthropometric indices and glycaemic control factors.
Coordinated planning of the distribution system and regional energy network in the presence of responsive loads
Authors: Dehghani Sanij Mohammad , Mirzaei Ahmad , Anvari‐Moghaddam Amjad 
Published: July 2023

AbstractReducing loss and providing a secure power supply for customers have always been the main goal of distribution systems planners. Recently, the development of competitive electricity markets and responsive loads participation in such markets together with the integration of regional energy networks (RENs) have resulted in creating some challenges for RENs' owners to increase operating efficiency, and reduce investment costs. In this paper, to overcome these problems, a new modeling for coordinated planning of distribution networks and RENs in the presence of responsive loads is proposed and to achieve the optimal solution of the problem, the genetic algorithm is used. Operation uncertainties due to the installation of wind turbines and photovoltaic resources in RENs are considered. The probability‐tree method is used to generate and model operation scenarios and their variable production, respectively. To validate and confirm the efficiency of the proposed model, numerical studies were applied on a 25‐bus Institute of Electrical and Electronics Engineers standard distribution network, including two RENs equipped with responsive loads. The results show the fact that the flexibility of the demand side in the electrical sector due to the activity of responsive loads causes to increase in the installation capacity of energy resources and storages.
Children's Oncology Group 2023 blueprint: Nursing discipline
Authors: Zupanec Sue , Herriage Teresa , Landier Wendy ,   the COG Nursing Discipline
Published: July 2023

AbstractIn contrast to other Children's Oncology Group (COG) committees, the COG nursing discipline is unique in that it provides the infrastructure necessary for nurses to support COG clinical trials and implements a research agenda aimed at scientific discovery. This hybrid focus of the discipline reflects the varied roles and expertise within pediatric oncology clinical trials nursing that encompass clinical care, leadership, and research. Nurses are broadly represented across COG disease, domain, and administrative committees, and are assigned to all clinically focused protocols. Equally important is the provision of clinical trials‐specific education and training for nurses caring for patients on COG trials. Nurses involved in the discipline's evidence‐based practice initiative have published a wide array of systematic reviews on topics of clinical importance to the discipline. Nurses also develop and lead research studies within COG, including stand‐alone studies and aims embedded in disease/ treatment trials. Additionally, the nursing discipline is charged with responsibility for developing patient/family educational resources within COG. Looking to the future, the nursing discipline will continue to support COG clinical trials through a multifaceted approach, with a particular focus on patient‐reported outcomes and health equity/disparities, and development of interventions to better understand and address illness‐related distress in children with cancer.
Curcumin inhibits esophageal squamous cell carcinoma progression through down‐regulating the circNRIP1/miR‐532‐3p/AKT pathway
Authors: Luo Tianxia , Guan Hongya , Liu Jia , Wang Jiang , Zhang Yueli 
Published: July 2023

AbstractCurcumin shows an anti‐cancer role in many kinds of tumors. However, the mechanism of its anti‐tumor function in esophageal squamous cell carcinoma (ESCC) remains largely unknown. Herein, we explored the therapeutic potential of curcumin for esophageal cancer. Curcumin could time‐ and dose‐dependently inhibit ESCC cells activity. Additionally, ESCC cells exposed to 20 μM of curcumin exhibited significantly decreased proliferative and invasive capacities, as well as enhanced cell apoptosis. ESCC tissues and cells exhibited significantly increased circNRIP1 expression when compared to their counterparts. circNRIP1 knockdown markedly impaired cell proliferation, clone formation, cell migration and invasion but promoted apoptosis. Exposure to 10–20 μM of curcumin inhibited circNRIP1 expression, however, overexpression of circNRIP1 could significantly restored the biological characteristics that were inhibited by curcumin exposure in vivo and in vitro. circNRIP1 promoted the malignancy of ESCC by combining miR‐532‐3p, and downstream AKT3. Curcumin inhibited AKT phosphorylation by up‐regulating miR‐532‐3p expression, thereby inhibiting the activation of the AKT pathway. In summary, curcumin is a potent inhibitor of ESCC growth, which can be achieved through the regulation of the circNRIP1/miR‐532‐3p/AKT pathway. This research may provide new mechanisms for curcumin to inhibit the malignant development of ESCC.
The Quality in 3D Acquisition of Cultural Heritage Assets: Challenges and Risks
Authors: Chatzistamatis Stamatis , E.Tsekouras George , Anagnostopoulos Christos-Nikolaos 
Published: July 2023

AbstractCultural heritage is an integral part of history and in order to better preserve, manage and highlight our cultural heritage it is necessary to first proceed to digitize and document it. Geometric documentation of a cultural heritage asset is the process of collecting, processing, rendering, and recording data to determine the location and actual form, shape, and size of a monument in three-dimensional space at a given time. This chapter presents the modern methods and technologies for the 3D acquisition of cultural heritage assets and discusses the related challenges and risks. Moreover, we are presenting the possible quality aspects observed in the fieldwork that arise from the equipment, the environmental conditions that prevail during the surveying, the object itself, the personnel expertise and the stakeholder conditions.
How to Measure Quality Models? Digitization into Informative Models Re-use
Authors: Brumana R. 
Published: July 2023

Abstract3D models from passive muted subjects, often used in the books and in preservation design reports as powerful images dense of contents, have nowadays the opportunity to become 'live gears’ leveraging knowledge, interpretation, and management into preservation objectives till to better-informed fruition. To this aim, we need to build up reliable and re-usable 3D Quality models. How to shift from a 3D model toward a 3D quality model?This contribution intends to focus on the parameters defining a 3D Quality model catching the heritage complexity with its components in a holistic methodological and practical vision. A radar chart has been used to manage all the parameters. First of all, Geometry describes a quality model: parameters for data acquisition, on-site surveying, and model processing to obtain 2D-3D Geometry quality are defined. The concept of scale associated with measurable parameters defining the Grade of Accuracy is proposed and applied to the surveying and to the 3D models. 3D models can be considered tools to decode the complexity of cultural heritage made by the different transformations across the centuries, anthropic-natural hazards, climate change threats and events (such as earthquakes, fires, wars). Thus, Geometry is not enough to describe such complexity; it represents the first step. Materials and Construction technologies analysis is the second pillar qualifying a quality model. The connection with the indirect data source (i.e., historical reports and archives documents), is the third pillar to be reconnected to the Geometry and Material analysis in the quality definition. HBIM represents a multidisciplinary environment to convey the information related to geometry and models. Furtherly, several parameters are identified to describe the quality of informative models, as in the case of Object Libraries and Building archeology progressively feeding such models. BIM Level of Developments (phases) and Level of Geometry (contents, not scale!) have been adapted to the HBIM, introducing digitization, surveying, and HBIM modeling into the preservation process. Finally, a quality model is defined by the capability to be re-used circulating Information and Models among the end-users as in the case of informed VR/AR through CDE and XR platforms.
UV-polymerizable methacrylated gelatin (GelMA)-based hydrogel containing tannic acids for wound healing
Authors: do Nascimento Marismar F. , de Oliveira Clauberto R. , Cardoso Juliana C. , Bordignon Natalia C. T. , Gondak Rogério , Severino Patrícia , Souto Eliana B. , de Albuquerque Júnior Ricardo L. C. 
Published: July 2023

AbstractGelatin-based photopolymerizable methacrylate hydrogel (GelMA) is a promising biomaterial for in situ drug delivery, while aqueous extract of Punica granatum (AEPG) peel fruit rich in gallic acid and ellagic acid is used to improve wound healing. The aim of this study was to develop and analyze the healing properties of GelMA containing AEPG, gallic acid, or ellagic acid in a rodent model. GelMA hydrogels containing 5% AEPG (GelMA-PG), 1.6% gallic acid (GelMA-GA), or 2.1% ellagic acid (GelMA-EA) were produced and their mechanical properties, enzymatic degradation, and thermogravimetric profile determined. Wound closure rates, healing histological grading, and immunohistochemical counts of myofibroblasts were assessed over time. The swelling of hydrogels varied between 50 and 90%, and GelMA exhibited a higher swelling than the other groups. The GPG samples showed higher compression and Young’s moduli than GelMA, GGA, and GAE. All samples degraded around 95% in 48 h. GPG and GGA significantly accelerated wound closure, improved collagenization, increased histological grading, and hastened myofibroblast differentiation in comparison to the control, GelMA, and GEA. GelMA containing AEPG (GPG) improved wound healing, and although gallic acid is the major responsible for such biological activity, a potential synergic effect played by other polyphenols present in the extract is evident.
Graphical Abstract
Impact of migration on diabetes burden: audit in the metropolitan area of Bologna, Italy
Authors: Marchesini G. , Gibertoni D. , Giansante C. , Perlangeli V. , Grilli R. , Scudeller L. , Descovich C. , Pandolfi P. 
Published: July 2023

Abstract
Purpose
To investigate the impact of diabetes in immigrants on the Italian healthcare system, as well as their compliance with standard protocols of control and treatment.

Methods
The prevalence of immigrants with diabetes living in the metropolitan area of Bologna (about 1 million inhabitants) in 2019 was investigated using a database containing all subjects in active follow-up for diabetes, based on antidiabetic drug use, disease-specific copayment exemption, ICD-9 codes, continuous care in diabetes units. Country of origin was derived from fiscal code.

Results
The overall prevalence of diabetes (n = 53,941; 51.8% males, median age 64) was 6.1% in both Italy-born and immigrant cohorts. Immigrant prevalence was 12.4%, moderately higher than that observed in the total population (12.2%). Diabetes risk was increased in the whole immigrant cohort (odds ratio (OR) 1.74; 95% Confidence Interval (CI) 1.69–1.79). Among cases with incident diabetes, the proportion of immigrants (median age, 49 vs. 65 in Italy-born individuals) increased progressively from 11.7% to 26.5% from 2011 to 2019 (males, 8.9–21.0%; females, 14.9–32.8%) in all age groups, particularly in young adults, but also in older subjects. Metabolic control was lower in immigrants, as was adherence to shared diagnostic and therapeutic protocols, without systematic differences in antidiabetic drug use, but much lower use of drugs for comorbid conditions.

Conclusions
The population with diabetes in the metropolitan area of Bologna is rapidly changing. Quality improvement initiatives are needed to reduce the burden for the universalistic Italian health care system generated by the rapidly-growing high-risk immigrant population.
Density-Dependent Pore Water Pressure Evolution in a Simplified Cyclic Shear Test
Authors: Baćić Božana , Herle Ivo 
Published: July 2023

AbstractWhen specimens of different sands are produced using the same preparation method and sheared under the same conditions (consolidation stress, loading, etc.), while simultaneously keeping the drainage closed, the resulting tendencies of these sands regarding the PWP build-up will be different. This research paper presents a simplified cyclic shear test, which is used to evaluate the accumulation of PWP in sands under defined specimen preparation procedure and testing conditions. In the proposed experiment, a comparison of different sands with this respect is easily achieved. The principle of this experimental method is based on the evolution of the PWP during cyclic shearing of a water-saturated sand sample. Undrained conditions during the experiment allow for the evolution of the PWP, which is quantified by the rate of the PWP build-up. The duration of a single cyclic shear test, including specimen preparation, is approximately 30 min. The evaluation of the rate of the PWP build-up for different densities resulted in an exponential dependence of the PWP build-up on the variation of the relative density. The results confirmed a higher generation of PWP in a fine sand compared to a coarse sand. A comparison with the results of undrained cyclic triaxial tests in the case of eight different sands demonstrated a good agreement between both experimental methods. The basis for the comparison was the density-dependent evolution of PWP in these methods. The presented method delivers a value (index) that quantifies the PWP build-up in sands under the defined testing conditions.
The influence of substituting dietary peptide-bound with free amino acids on nitrogen metabolism and acid–base balance of broiler chickens depends on asparagine and glutamine supply
Authors: Ibrahim Ahmad , Kenéz Ákos , Rodehutscord Markus , Siegert Wolfgang 
Published: July 2023

AbstractReducing dietary crude protein (CP) concentration while maintaining adequate amino acid (AA) supply by free AA inclusion can contribute to attenuate the negative environmental effects of animal farming. This study investigated upper limits of dietary free AA inclusions without undesirable effects including the dependence on asparagine (Asn) and glutamine (Gln) supply. Ten broilers were allocated to sixty-three metabolism units each and offered nine experimental diets from day (d) 7–21 (n 7). One diet (167 g CP/kg) contained 80 g soya protein isolate (SPI)/kg. In the other diets, 25, 50, 75 and 100 % of the digestible AA from SPI were substituted with free AA. Digestible Asn+aspartic acid (Asp) and Gln+glutamic acid (Glu) were substituted with Asp/Glu or 50/50 mixes of Asp/Asn and Glu/Gln, respectively. Total excreta were collected from d 11–14 and from d 18–21. Growth and nitrogen accretion were unaffected by 25 and 50 % substitution without and with free Asn/Gln, respectively, but decreased at higher substitution (P ≤ 0·024). Circulating concentrations of Asp, Glu and Gln were unaffected by treatment, while Asn decreased at substitution higher than 50 % when Asn/Gln were not provided (P ≤ 0·005). Blood gas analysis on d 21 indicated a compensated metabolic acidosis at substitution higher than 50 and 75 % without and with free Asn/Gln, respectively (P ≤ 0·017). Results suggest that adding Asn/Gln increased an upper limit for proportion of dietary free AA from 10 to 19 % of dietary CP and enabled higher free AA inclusion without affecting the acid–base balance.
Redefining attrition in multiple myeloma (MM): a Canadian Myeloma Research Group (CMRG) analysis
Authors: McCurdy Arleigh , Mian Hira , LeBlanc Richard , Jimenez-Zepeda Victor H. , Su Jiandong , Masih-Khan Esther , Visram Alissa , Louzada Martha , Song Kevin , White Darrell , Sebag Michael , Stakiw Julie , Reiman Anthony , Aslam Muhammad , Bergstrom Debra , Kotb Rami , Kaedbey Rayan , Gul Engin , Reece Donna , Venner Christopher P. 
Published: July 2023

AbstractWhile most patients diagnosed with multiple myeloma (MM) receive initial therapy, reported attrition rates are high. Understanding attrition rates and characteristics of patients not receiving subsequent therapy is useful for MM stakeholders. We performed an analysis of attrition rates in a large disease-specific database of patients with newly diagnosed MM who received at least one line of therapy between Jan 1/10-Dec 31/20. Attrition was defined as failure to receive a subsequent line of therapy despite progression of MM or due to death. A total of 5548 patients were identified, 3111 autologous stem cell transplant (ASCT) patients and 2437 non-ASCT. In the ASCT cohort, the attrition rate was 7% after line 1, 12% after line 2, and 23% after line 3. In non-ASCT patients, the attrition rate was 19% after line 1, 26% after line 2, and 40% after line 3. Death was the dominant contributor to attrition across all cohorts, with a minority of patients alive with progressive disease in the absence of further therapy at each line. Multivariable analysis identified older age, shorter time to progression, and inferior response as independent risk factors for attrition. Our data show that attrition rates increase with each line of therapy and are higher in non-ASCT patients but are appreciably lower than previously reported. This study supports a revision of the previous definition of attrition, demonstrating that most patients who do not receive subsequent therapy are either continuing their current therapy and/or are in remission off-treatment rather than being irreversibly lost to attrition.
Local colonisations and extinctions of European birds are poorly explained by changes in climate suitability
Authors: Howard Christine , Marjakangas Emma-Liina , Morán-Ordóñez Alejandra , Milanesi Pietro , Abuladze Aleksandre , Aghababyan Karen , Ajder Vitalie , Arkumarev Volen , Balmer Dawn E. , Bauer Hans-Günther , Beale Colin M. , Bino Taulant , Boyla Kerem Ali , Burfield Ian J. , Burke Brian , Caffrey Brian , Chodkiewicz Tomasz , Del Moral Juan Carlos , Mazal Vlatka Dumbovic , Fernández Néstor , Fornasari Lorenzo , Gerlach Bettina , Godinho Carlos , Herrando Sergi , Ieronymidou Christina , Johnston Alison , Jovicevic Mihailo , Kalyakin Mikhail , Keller Verena , Knaus Peter , Kotrošan Dražen , Kuzmenko Tatiana , Leitão Domingos , Lindström Åke , Maxhuni Qenan , Mihelič Tomaž , Mikuska Tibor , Molina Blas , Nagy Károly , Noble David , Øien Ingar Jostein , Paquet Jean-Yves , Pladevall Clara , Portolou Danae , Radišić Dimitrije , Rajkov Saša , Rajković Draženko Z. , Raudonikis Liutauras , Sattler Thomas , Saveljić Darko , Shimmings Paul , Sjenicic Jovica , Šťastný Karel , Stoychev Stoycho , Strus Iurii , Sudfeldt Christoph , Sultanov Elchin , Szép Tibor , Teufelbauer Norbert , Uzunova Danka , van Turnhout Chris A. M. , Velevski Metodija , Vikstrøm Thomas , Vintchevski Alexandre , Voltzit Olga , Voříšek Petr , Wilk Tomasz , Zurell Damaris , Brotons Lluís , Lehikoinen Aleksi , Willis Stephen G. 
Published: July 2023

AbstractClimate change has been associated with both latitudinal and elevational shifts in species’ ranges. The extent, however, to which climate change has driven recent range shifts alongside other putative drivers remains uncertain. Here, we use the changing distributions of 378 European breeding bird species over 30 years to explore the putative drivers of recent range dynamics, considering the effects of climate, land cover, other environmental variables, and species’ traits on the probability of local colonisation and extinction. On average, species shifted their ranges by 2.4 km/year. These shifts, however, were significantly different from expectations due to changing climate and land cover. We found that local colonisation and extinction events were influenced primarily by initial climate conditions and by species’ range traits. By contrast, changes in climate suitability over the period were less important. This highlights the limitations of using only climate and land cover when projecting future changes in species’ ranges and emphasises the need for integrative, multi-predictor approaches for more robust forecasting.
Order–disorder and ionic conductivity in calcium nitride-hydride
Authors: Irvine G. J. , Smith Ronald I. , Jones M. O. , Irvine J. T. S. 
Published: July 2023

AbstractRecently nitrogen-hydrogen compounds have successfully been applied as co-catalysts for mild conditions ammonia synthesis. Ca2NH was shown to act as a H2 sink during reaction, with H atoms from its lattice being incorporated into the NH3(g) product. Thus the ionic transport and diffusion properties of the N–H co-catalyst are fundamentally important to understanding and developing such syntheses. Here we show hydride ion conduction in these materials. Two distinct calcium nitride-hydride Ca2NH phases, prepared via different synthetic paths are found to show dramatically different properties. One phase (β) shows fast hydride ionic conduction properties (0.08 S/cm at 600 °C), on a par with the best binary ionic hydrides and 10 times higher than CaH2, whilst the other (α) is 100 times less conductive. An in situ combined analysis techniques reveals that the effective β-phase conducts ions via a vacancy-mediated phenomenon in which the charge carrier concentration is dependent on the ion concentration in the secondary site and by extension the vacancy concentration in the main site.