bluuebunny/crossref_metadata_2025_split huggingface dataset:
Electrocoagulation process for the decolorization of wastewater containing Reactive Red 195 and CFD simulation of the hydrodynamic in a continuous-flow single-channel reactor
Authors: Lamhar Raowia , Kambuyi Toussaint Ntambwe , Zmirli Zakia , Aguelmous Anas , Bejjany Bouchra , Digua Khalid , Dani Adil 
Published: May 2023

Abstract

The highly colored textile effluents require efficient treatment before being released into the environment. In this study, a continuous-flow single-channel reactor operating in closed- circuit was used to apply electrocoagulation for the treatment of synthetic textile wastewater. First, the characterization of the hydrodynamic within the reactor is evaluated by Computational Fluid Dynamics simulation using the k-ε turbulence model (Comsol Multiphysics®). Apart from a non-uniform distribution of the velocities inside the reactor, no particular anomaly was observed. Second, the decolorization efficiency was examined under various current intensities, electrolysis times, and initial dye concentrations. By operating under a current intensity of 100 mA instead of 50 mA, the required electrolysis time to achieve a decolorization efficiency of 80% decreased by 40%, while the specific electrode consumption remained slightly unchanged at about 0.19 kg Al·kg−1. At a current intensity of 100 mA and an electrolysis time of 26 min, and the increase in the initial dye concentration from 10 to 50 mg·L−1 the decolorization efficiency decreased remarkably while the specific electrode consumption was kept constant at about 0.15 kg Al·kg−1 dye removed. The knowledge obtained through this study can be used for the transposition from batch to continuous mode.
Boron bio-mining by high boron-tolerant native microalgae in Turkey and boron toxicity in the aquatic environment
Authors: Taştan Burcu Ertit , Bakir Bahtiyar , Dönmez Gönül 
Published: May 2023

Abstract

Boron (B) is one of the most important trace elements. Turkey has the largest B reserves in the world with 3 billion tons of B. Therefore, the toxicity of B is more important in Turkey. In this study, effective B removal was provided by different types of microalgae and then B recovery in culture media by bio-mining was detected. The water of Lake Mogan in Gölbaşı/Ankara/Turkey was used as the microalgae culture medium as a cost-reducing factor. The effects of light, temperature, NaNO3 and K2HPO4 stresses on B removal were determined. The highest B removal was 17.19% at 25 μmol/m2s light intensity and 25 °C for Phormidium animale in Lake Mogan culture medium. Boron removal of Scenedesmus sp. was 36.42% at 25 μmol/m2s light intensity, at 25 °C, at 1.5 g/L NaNO3 and 40 mg/L K2HPO4 concentrations in BG11 medium on the 15th day. The chl (a + b) concentration of Scenedesmus sp. was 1.63 μg/mL at 75 μmol/m2s light intensity and the chl (a) concentration of P. animale was 2.01 μg/mL at 25 μmol/m2s light intensity. Considering all parameters, Scenedesmus sp. and P. animale are recommended as effective biomaterials for the B removal process.
Expression and Prognostic Role of PANK1 in Glioma
Authors: Zhao Zhiming , Xu Xu , Ma Shijing , Li Li 
Published: May 2023

Background:
Malignant gliomas are the most common type of primary malignant brain
tumors. Pantothenate kinase 1 (PANK1) mRNA is highly expressed in several metabolic processes,
implying that PANK1 plays a potential role in metabolic programming in cancers. However, the
role of PANK1 in glioma has not been fully explored.

Methods:
Public datasets (The Cancer Genome Atlas (TCGA), Chinese Glioma Genome Atlas
(CGGA), Gravendeel and Rembrandt) and validation cohort were used to explore the expression of
PANK1 in glioma tissues. Kaplan–Meier and Cox regression analyses were used to explore the relationship
between PANK1 and prognosis in glioma. Cell proliferation and invasion were determined
using Cell Counting Kit-8 (CCK8) and transwell invasion in vitro assays.

Results:
Analysis using the four public datasets and the validation cohort showed that PANK1 expression
was significantly downregulated in glioma tissues compared with non-tumor tissues
(P<0.01). PANK1 expression was negatively correlated with World Health Organization (WHO)
grade, 1p/19q non-codeletion and isocitric dehydrogenase 1/2 (IDH1/2) wildtype. Furthermore,
high expression of PANK1 was correlated with significantly better prognosis of glioma patients
compared to patients with low expression of PANK1 (all P<0.01 in the four datasets). Besides,
both lower-grade glioma (LGG) and glioblastoma multiform (GBM) patients with high expression
of PANK1 had a significantly better prognosis than those with low expression of PANK1 in
TCGA, Gravendeel and Rembrandt datasets (all P <0.01). Multivariate Cox regression analysis revealed
that low PANK1 expression was an independent risk factor associated with a worse prognosis
of glioma patients. Moreover, overexpression of PANK1 significantly inhibited the proliferation
and invasion of U87 and U251 cells.

Conclusion:
PANK1 expression is downregulated in glioma tissues and is a novel prognostic
biomarker in glioma patients
Mechanisms of Er Chen Tang on Treating Asthma Explored by Network
Pharmacology and Experimental Verification
Authors: Ren Yuzhe , Zhang Haijing , Yu Zhou , Yang Xiangzheng , Jiang Deyou 
Published: May 2023

Objective:
The aim of this study is to explore the active ingredients of ECT and their
targets for asthma and investigate the potential mechanism of ECT on asthma.

Methods:
Firstly, the active ingredients and target of ECT were screened for BATMAN and
TCMSP, and functional analysis was done via DAVID. Then, the animal model was induced by
ovalbumin (OVA) and aluminum hydroxide. Eosinophil (EOS) counts, EOS active substance Eosinophilic
cationic protein (ECP) and eotaxin levels were detected following the instruction. Pathological
changes in lung tissue were examined by H&E staining and transmission electron microscopy.
Interleukin (IL-4, IL-10, IL-13, TNF-α), TIgE and IgE levels in bronchoalveolar lavage fluid
(BALF) were measured by ELISA. Finally, the protein expression of the TGF-β / STAT3 pathway
to lung tissue was detected by Western Blot.

Results:
A total of 450 compounds and 526 target genes were retrieved in Er Chen Tang. Functional
analysis indicated that its treatment of asthma was associated with inflammatory factors and
fibrosis. In the animal experiment, the results showed that ECT significantly regulated inflammatory
cytokine (IL-4, IL-10, IL-13, TNF-α) levels in (P<0.05, P<0.01, reduced EOS number (P<0.05)
and also ECP and Eotaxin levels in the blood (P<0.05) in BALF and/or plasma. Bronchial tissue
injury was obviously improved on ECT treatment. Associated proteins in TGF-β / STAT3 pathway
were significantly regulated by ECT (P<0.05).

Conclusion:
This study originally provided evidence that the Er Chen Tang was effective in the
treatment of asthma symptoms, and its underlying mechanism might be the regulation of inflammatory
factor secretion and the TGF-β/STAT3 signaling pathway.
The cGAS-STING Pathway: A Ubiquitous Checkpoint Perturbing Myocardial
Attributes
Authors: Wan Xueqi , Tian Jinfan , Hao Peng , Zhang Jing , Zhou Yuquan , Ge Changjiang , Song Xiantao 
Published: May 2023

Abstract:
As an innate immune route of defense against microbial infringement, cyclic guanosine
monophosphate (GMP)–adenosine monophosphate (AMP) synthase (cGAS)- stimulator of interferon
genes (STING) signaling does not simply participate in amplifying inflammatory responses via releasing
type-I interferon (IFN) or enhance the expression of pro-inflammatory genes, but also interplays
with multifarious pathophysiological activities, such as autophagy, apoptosis, pyroptosis, ferroptosis,
and senescence in a broad repertoire of cells like endothelial cells, macrophages and cardiomyocyte.
Thus, the cGAS-STING pathway is closely linked with aberrant heart morphologically and functionally
via these mechanisms. The past few decades have witnessed an increased interest in the exact relationship
between the activation of the cGAS-STING pathway and the initiation or development of certain
cardiovascular diseases (CVD). A group of scholars has gradually investigated the perturbation of myocardium
affected by the overactivation or suppression of the cGAS-STING. This review focuses on how
the cGAS-STING pathway interweaves with other pathways and creates a pattern of dysfunction associated
with cardiac muscle. This sets treatments targeting the cGAS-STING pathway apart from traditional
therapeutics for cardiomyopathy and achieves better clinical value.
Promoting Oncolytic Vector Replication with Switches that Detect Ubiquitous
Mutations
Authors: Renteln Michael A. 
Published: May 2023

Abstract:
Most existing cancer therapies negatively affect normal tissue as well as cancerous tissue.
A potentially effective strategy for treating cancer that precludes off-target damage and could be an
option for most patients would involve targeting one or more mutations that are ubiquitous in the
given patient’s tumor(s). To effect this strategy, one would employ multi-region sequencing of a patient’s primary tumor and metastases to seek out mutations that are shared between all or at least
most regions. Once the target or targets are known, one would ideally rapidly generate a molecular
switch for at least one of said ubiquitous mutations that can distinguish the mutated DNA, RNA, or
protein from the wild-type version and subsequently trigger a therapeutic response. I propose that
the therapeutic response involve the replication of an oncolytic virus or intracellular bacterium, as
any mutation can theoretically be detected by a vector that enters the cell - and automatic propagation could be very helpful. Moreover, the mutation “signal” can be easily enhanced through transcriptional and translational (if the target is an intracellular protein) enhancement. Importantly, RNA
may make the best target for the molecular switches in terms of amplification of the signal and ease
of targeting.
Current Expansion of Silver and Gold Nanomaterials towards Cancer
Theranostics: Development of Therapeutics
Authors: Gupta Pawan , Mishra Kritigya , Mittal Amit Kumar , Handa Neha , Paul Manash K. 
Published: May 2023

Abstract:
Nanomaterial-based therapeutics is an emerging tool for the treatment of numerous
types of cancer. Various types of polymeric, lipid and inorganic nanoparticles (NPs) result in a
wider series of applications in cancer diagnosis and therapeutics. The NPs properties are due to
high surface area to volume ratio, surface plasmon resonance, absorption in the visible spectrum
and light scattering. These unique characteristics of NPs arise due to their optical surface properties
for conjugation/surface modification and smaller size. In cancer therapeutics, NPs based
products are used as a biomarker for early detection/diagnosis of tumours, drug nano-conjugates
for the delivery of chemotherapeutic drugs to the tumour-specific site, chemo-protective agents,
etc.

:
Furthermore, other advantages of NPs are biocompatibility, lesser toxicity, enhanced permeability
and retention effect, higher stability, and specific targeting with a selective accumulation of nano
drugs in the tissue of the tumour. The selective targeting of NPs to tumour tissue is possible by
adding surface-active targeting agents i.e., antibodies. The selective transport of drug NPs conjugates
to the cancer cells is increased and extravagated due to permeable vasculature from endothelial
cells gap while failing the transport of drug NPs conjugates in normal cells. This review emphasizes
metallic NPs, including silver NPs (AgNPs) and gold NPs (AuNPs), which are extensively
reconnoitered in various applications in cellular targeting, imaging, drug delivery, DNA-NPs
conjugates for biosensor/point of care devices development, photothermal/photodynamic therapy,
protein-protein interaction, etc. In addition, this review discussed different synthetic methods of
AgNPs and AuNPs and characterization methods. Furthermore, it highlighted the different properties
and applications of AgNPs and AuNPs in cancer theranostics.
Germacrone, A Novel and Safe Anticancer Agent from Genus Curcuma: A Review of
its Mechanism
Authors: Lou Guanhua , Huang Yan , Wang Yu , Chen Shiyun , Liu Chang , Li Ying , Feng Jianan 
Published: May 2023

Abstract:
Germacrone, a kind of natural sesquiterpenoid compound, has been reported to exhibit many pharmacological properties, especially the anticancer effect. Many in vitro experiments have been performed on various cancer cell
lines, trying to explore their anticancer mechanism. Aiming at investigating the anticancer effect of germacrone, this
article reviews the extant information on existing literature about germacrone-related studies. The anticancer mechanisms and clinical usages of germacrone are summarized. Literature databases (such as PubMed and CNKI) are used to
search the current studies and experimental research about the anticancer effect information of germacrone. Anticancer
mechanism of germacrone includes cell cycle arrest inducing, programmed cell death (apoptosis, autophagy, pyroptosis
and ferroptosis) inducing, and estrogen-related genes mediating. Structural modification and analogue design are worthy of further study in the future
HEALTH AND HYGIENE RELATED PROBLEMS AMONG SLUM WOMEN
Authors: Shukla Ratna 
Published: May 2023

Slums are the areas of substandard housing conditions within a city .The United Nations defines the slum as ... a building, group of buildings or area characterized by overcrowding, deterioration, unsanitary conditions or absence of facilities or amenities which, because of these conditions or any of them in danger, the health, the safety or morals of its inhabitants or the community. Various terms such as 'blighted area', 'deteriorated areas', ' marginal areas', 'transitional areas', 'substandard settlement', 'provisional settlement', 'squatter settlement', 'overnight settlement', 'urban villages' etc. are very loosely used to denote slums.
It has been found by number of researchers that due to poor economic and educational status, awareness regarding health and hygiene is found to be very poor among slum dwellers. Slums are very prone to unhygienic and unhealthy conditions because of their socio-ecological settings. Slum areas have been the breeding grounds of epidemics such as cholera, jaundice, hepatic disorder. Infectious diseases like tuberculosis, chest disease like asthma, lung cancer due to excessive use of tobacco, alcohol and spirit are very common. Abject poverty, social and economic deprivations, lack of essential food and nutrients and the unhygienic and contaminated water force them to live on the mercy of nature than on human resources. The water borne diseases like amoebiasis, helmenthiasis, diarrhoea, dysentery, viral hepatitis, and typhoid are very much common among them. Eighty to ninety percent of the slum inhabitants have no access to human waste disposal facilities. These conditions render the surroundings polluted and un conducive for human habitation resulting in environmental degradation. These slum dwellers are also not aware of small family norms. The size of their family is very large. Child marriages are prevalent among them.
In spite of hard work by the women in slum, their condition is very bad. They have very low literacy rate and their economic condition is also not good. Most of the slum women get married at the age of 13 to 15 years. But the condition of unmarried girls is also far from satisfactory. They are treated as an unpaid worker who helps in cooking food, cleaning utensils and looking up their young brothers and sisters when the parents go to their work.	Socially, these women's are very much deprived and engaged in anti-social work and are the easy victim of unhealthy physical as well as social environment.
The Role of Metabolic Dysfunction–Associated Fatty Liver Disease in Developing Chronic Kidney Disease: Longitudinal Cohort Study
Authors: Wei Suosu , Song Jian , Xie Yujie , Huang Junzhang , Yang Jianrong 
Published: May 2023

Background
The association between metabolic dysfunction–associated fatty liver disease (MAFLD) and chronic kidney disease (CKD) is unclear.

Objective
This longitudinal cohort study aimed to test whether MAFLD plays an important role in the development of CKD.

Methods
This cohort study included 41,246 participants who had undergone 3 or more health examinations from 2008 to 2015 at the People’s Hospital of Guangxi Zhuang Autonomous Region, China. Participants were categorized into 2 groups according to whether they presented with or without MAFLD. The occurrence of new-onset CKD was stated as either an estimated glomerular filtration rate of <60 mL/min per 1.73 m2 or a higher level of albuminuria during their follow-up appointment. The association between MAFLD and CKD was evaluated using a Cox regression method.

Results
Of the 41,246 participants, 11,860 (28.8%) were diagnosed with MAFLD. Over the course of the 14-year follow-up (median 10.0 years), 5347 (13%) participants experienced a new incident of CKD (135.73 per 10,000 person-years). MAFLD was discovered as an important risk factor for new incidents of CKD (hazard ratio 1.18, 95% CI 1.11-1.26) by using the multivariable Cox proportional hazard regression model. When stratified by gender, the adjusted hazard ratio for the incidence of CKD in men and women with MAFLD were 1.16 (95% CI 1.07-1.26) and 1.32 (95% CI 1.18-1.48), respectively. According to the subgroup analysis results, after adjusting for confounding factors, the MAFLD-related CKD risk was greater in men aged <60 years (Pinteraction=.001) and in those with combined dyslipidemia (Pinteraction=.02), but this relationship was not found in women (all Pinteraction>.05).

Conclusions
MAFLD plays an important role in the development of new incidents of CKD in the long run.

Trial Registration
Chinese Clinical Trial Registry ChiCTR2200058543; https://www.chictr.org.cn/showproj.html?proj=153109
Patient Perceptions of e-Visits: Qualitative Study of Older Adults to Inform Health System Implementation
Authors: Judson Timothy J , Subash Meera , Harrison James D , Yeager Jan , Williams Aimée M , Grouse Carrie K , Byron Maria 
Published: May 2023

BackgroundElectronic visits (e-visits) are billable, asynchronous patient-initiated messages that require at least five minutes of medical decision-making by a provider. Unequal use of patient portal tools like e-visits by certain patient populations may worsen health disparities. To date, no study has attempted to qualitatively assess perceptions of e-visits in older adults.ObjectiveIn this qualitative study, we aimed to understand patient perceptions of e-visits, including their perceived utility, barriers to use, and care implications, with a focus on vulnerable patient groups.MethodsWe conducted a qualitative study using in-depth structured individual interviews with patients from diverse backgrounds to assess their knowledge and perceptions surrounding e-visits as compared with unbilled portal messages and other visit types. We used content analysis to analyze interview data.ResultsWe conducted 20 interviews, all in adults older than 65 years. We identified 4 overarching coding categories or themes. First, participants were generally accepting of the concept of e-visits and willing to try them. Second, nearly two-thirds of the participants voiced a preference for synchronous communication. Third, participants had specific concerns about the name “e-visit” and when to choose this type of visit in the patient portal. Fourth, some participants indicated discomfort using or accessing technology for e-visits. Financial barriers to the use of e-visits was not a common theme.ConclusionsOur findings suggest that older adults are generally accepting of the concept of e-visits, but uptake may be limited due to their preference for synchronous communication. We identified several opportunities to improve e-visit implementation.
Facilitadores y barreras de la transferencia de conocimiento entre sociedades cooperativas
Authors: Montoya Herrera Mariana , Rivera González Ángel Eustorgio 
Published: May 2023

La transferencia de conocimiento es una práctica que puede llevar a cabo cualquier tipo de organización, sin embargo, para su aprovechamiento requiere realizarse de manera organizada y sistematizada. El objetivo de este documento radica en identificar los facilitadores y las barreras para la transferencia de conocimiento inter organizacional a través del diseño y aplicación de un plan de actividades que permitieron hacer un seguimiento en la práctica con cuatro sociedades cooperativas de la Ciudad de México. La metodología aplicada fue cualitativa, basada en la observación participante y la aplicación de entrevistas semi estructuradas. La información se trabajó a través del análisis de contenido mediante la identificación de palabras claves y ejes temáticos. Esto permitió contrastar la teoría acerca los facilitadores y barreras de la misma. Entre los resultados más significativos se encontró que las sociedades cooperativas observadas requieren construir o consolidar una cultura organizacional que comprenda y favorezca la transferencia de conocimiento, para ser consecuentes con un valor organizativo propio como lo es la cooperación entre cooperativas; así como para lograr alianzas estratégicas, innovación e incluso replantearse el significado del conocimiento y del aprovechamiento de los recursos intangibles.
Методология профессиональной трансформации сферы жилищно-коммунального хозяйства
Authors: Чернышов Леонид Николаевич , Нелюбов Артем Валерьевич 
Published: May 2023

В статье представлены предпосылки трансформации кадрового потенциала предприятий ЖКХ, обусловленные организационно-­техническими и технологическими изменениями в отрасли, связанными с насыщением объектов капитального строительства современным высокотехнологичным оборудованием и интеллектуальными системами.
В этих условиях эволюция профессий происходит значительно быстрее. Требования к работнику смещаются из области исполнения функциональных обязанностей на достижение конечного результата, который показывает человек или которого он стремится достичь.
Современный рынок труда потребует от работников руководствоваться новой концепцией, основанной на принципах «образование на протяжении всей жизни». Одной профессии на всю жизнь больше не будет — придется постоянно адаптироваться к изменениям на рынке труда. Умение работника предприятия адаптироваться под потребности рынка труда и расширять свои компетенции становится важнее специальности.
Современные технологии, оборудование и методы контроля и управления становятся достоянием объектов ЖКХ в процессе их создания или обновления (модернизации, реконструкции, капитального ремонта), которые осуществляются и финансируются в соответствии с федеральными, региональными, муниципальными или корпоративными планами и программами на основании утвержденных проектов.
В свою очередь, внедрение интеллектуальных технологий в ЖКХ приводит не только к появлению новых и утрате невос­требованных отраслевых профессий, но и к появлению «гибридных» профессий, которые могут включать сочетание разно­образных, традиционно «не сочетающихся» умений и навыков.
«Ключом» к решению проблемы адаптации существующих квалификаций на рынке труда к требованиям, которые диктует технологическая революция, является реализация направлений Национальной системы квалификаций, основные элементы которой, — это внедрение профессиональных стандартов в сферу труда и образования.