bluuebunny/crossref_metadata_2025_split huggingface dataset:
Liposomal AntagomiR‐155‐5p Restores Anti‐Inflammatory Macrophages and Improves Arthritis in Preclinical Models of Rheumatoid Arthritis
Authors: Paoletti Audrey , Ly Bineta , Cailleau Catherine , Gao Fan , de Ponfilly‐Sotier Marie Péan , Pascaud Juliette , Rivière Elodie , Yang Luxin , Nwosu Lilian , Elmesmari Aziza , Reynaud Franceline , Hita Magali , Paterson David , Reboud Julien , Fay Francois , Nocturne Gaetane , Tsapis Nicolas , McInnes Iain B. , Kurowska‐Stolarska Mariola , Fattal Elias , Mariette Xavier 
Published: August 2023

ObjectiveWe previously reported an increased expression of microRNA‐155 (miR‐155) in the blood monocytes of patients with rheumatoid arthritis (RA) that could be responsible for impaired monocyte polarization to anti‐inflammatory M2‐like macrophages. In this study, we employed two preclinical models of RA, collagen‐induced arthritis and K/BxN serum transfer arthritis, to examine the therapeutic potential of antagomiR‐155‐5p entrapped within PEGylated (polyethylene glycol [PEG]) liposomes in resolution of arthritis and repolarization of monocytes towards the anti‐inflammatory M2 phenotype.MethodsAntagomiR‐155‐5p or antagomiR‐control were encapsulated in PEG liposomes of 100 nm in size and −10 mV in zeta potential with high antagomiR loading efficiency (above 80%). Mice were injected intravenously with 1.5 nmol/100 μL PEG liposomes containing antagomiR‐155‐5p or control after the induction of arthritis.ResultsWe demonstrated the biodistribution of fluorescently tagged PEG liposomes to inflamed joints one hour after the injection of fluorescently tagged PEG liposomes, as well as the liver's subsequent accumulation after 48 hours, indicative of hepatic clearance, in mice with arthritis. The injection of PEG liposomes containing antagomiR‐155‐5p decreased arthritis score and paw swelling compared with PEG liposomes containing antagomiR‐control or the systemic delivery of free antagomiR‐155‐5p. Moreover, treatment with PEG liposomes containing antagomiR‐155‐5p led to the restoration of bone marrow monocyte defects in anti‐inflammatory macrophage differentiation without any significant functional change in other immune cells, including splenic B and T cells.ConclusionThe injection of antagomiR‐155‐5p encapsulated in PEG liposomes allows the delivery of small RNA to monocytes and macrophages and reduces joint inflammation in murine models of RA, providing a promising strategy in human disease.image
Why does school socio‐economic composition matter to adolescents’ academic performance? Role of classroom climate and school resources
Authors: Chzhen Yekaterina , Leesch Julia 
Published: August 2023

AbstractA growing literature has documented the importance of school socio‐economic status (SES) composition to children's academic performance, but the channels through which school SES affects individual achievement remain poorly understood. We investigate differences in 15‐year‐old children's reading performance across schools with different levels of mean SES composition in six European countries where children are sorted into different academic and vocational tracks after the age of 15. This study contributes to the literature on the role of school SES composition for students’ academic achievement by examining the extent to which individual student SES and academic aspirations, classroom climate and school resources account for school SES differences. Multilevel regression analyses of reading literacy scores from PISA 2018 indicate sizeable effects of school SES composition on reading achievement in each of the six countries, even after accounting for student SES. By limiting the analysis to students who had not yet been tracked based on their academic record or aspirations, we can better focus on the link between school SES composition and educational achievement. Our main finding is that school SES composition differences are more than a function of students’ own SES, as they also reflect classroom discipline, teaching practices, peer educational aspirations, and to a lesser extent, school resources.
Insights into product and process related challenges of lentiviral vector bioprocessing
Authors: Perry Christopher , Mujahid Noor , Takeuchi Yasu , Rayat Andrea C. M. E. 
Published: August 2023

AbstractLentiviral vectors (LVs) are used in advanced therapies to transduce recipient cells for long term gene expression for therapeutic benefit. The vector is commonly pseudotyped with alternative viral envelope proteins to improve tropism and is selected for enhanced functional titers. However, their impact on manufacturing and the success of individual bioprocessing unit operations is seldom demonstrated. To the best of our knowledge, this is the first study on the processability of different Lentiviral vector pseudotypes. In this work, we compared three envelope proteins commonly pseudotyped with LVs across manufacturing conditions such as temperature and pump flow and across steps common to downstream processing. We have shown impact of filter membrane chemistry on vector recoveries with differing envelopes during clarification and observed complete vector robustness in high shear manufacturing environments using ultra scale‐down technologies. The impact of shear during membrane filtration in a tangential flow filtration‐mimic showed the benefit of employing higher shear rates, than currently used in LV production, to increase vector recovery. Likewise, optimized anion exchange chromatography purification in monolith format was determined. The results contradict a common perception that lentiviral vectors are susceptible to shear or high salt concentration (up to 1.7 M). This highlights the prospects of improving LV recovery by evaluating manufacturing conditions that contribute to vector losses for specific production systems.
Synthesis and solubility properties of amine‐functionalized fulleropyrrolidines in organic solvents
Authors: Lim Suk Hyun , Cho Dae Won 
Published: August 2023

AbstractIn this study, we prepared amine‐functionalized fullerene derivatives by using methylene blue (MB)‐sensitized photoaddition reactions of fullerene C60 with a variety of α‐silyl group containing N‐alkylglycinates through 1,3‐dipolar cycloaddition reactions of in situ formed azomethine ylide, derived from glycinates, to fullerene C60 and examined their solubility properties in several organic solvents. The results showed that although it was hard to find a clear correlation between the solvent solubility of and N‐substituents of fullereopyrrolidines, the solubility of functionalized fullerene derivatives in organic solvents such as toluene, CHCl3, CH2Cl2, and tetrahydrofuran (THF) was much higher than that of C60 and in addition, the solubility properties of fullereopyrrolidines can be manipulated by incorporating diverse organic moieties into fullerene surface.
Dissipation kinetics, residue determination and consumer risk assessment of acephate on green pea by gas chromatography–electron capture detector
Authors: Jan Ishrat , Dar Alamgir A. , Mukhtar Malik , Shah Mehraj D. , Wani Ashraf A. , Dar Shahnawaz R. , Dar Irshad H. , Sofi Javid A. 
Published: August 2023

AbstractThe present study on “acephate persistence on green pea” was conducted in SKUAST‐Kashmir. The study aimed to determine the persistence, dissipation kinetics and waiting period of acephate on green pea. Acephate was sprayed at 75% soluble powder (SP) at 560 g a.i.ha−1 at the fruiting stage followed by another application at a 10 day interval. A rapid and accurate method (quick, easy, cheap, effective, rugged and safe, QuEChERS) was used for extraction and the residue was determined by gas chromatography–electron capture detection on a CPSIL‐8CB capillary column (0.25um film thickness, 0.25 mm i.d, 30 m length). At the fortification levels of 0.05, 0.1 and 0.5 mg kg−1, the percentage recovery of acephate on green pea was found in the range of 71–107%. The initial deposit of green pea was estimated to be 0.37 mg kg−1. At the indicated dose, the residue of acephate on green pea dissipated below the limit of quantification of 0.05 mg kg−1 after 10 days. Acephate degradation was quick in green pea, with a half‐life of 4.07 days. For safe eating of green peas, a 10 day waiting period is recommended. The gas chromatography–electron capture detection technique was validated by following the SANTE standards.
The effects of green brand image on brand loyalty: The case of mainstream fast food brands
Authors: Watson Anna , Perrigot Rozenn , Dada Olufunmilola (Lola) 
Published: August 2023

AbstractWhile a number of studies have explored consumer attitudes and behaviors towards green brands, the importance of green brand image for mainstream brands is less well understood. This study seeks to explore if the green image of mainstream fast food brands influences consumer loyalty and how their attitudes towards and knowledge of environmental issues may affect perceptions of the environmental performance of fast food brands. Using data gathered from a convenience sample of 2001 Gen Y and Gen Z consumers in France, our study establishes a critical linkage between consumers' environmental values and brand loyalty by including green brand image as a mediator. Further, by exploring mainstream brands, rather than brands that are positioned primarily on green attributes, we find that the mediating effect of green brand image may be dependent on the brand positioning.
Thermodynamic Analysis of Membrane Separation‐Enhanced Co‐Hydrogenation of CO2/CO to Ethanol
Authors: Chen Jian , Fu Weijie , Liu Shuilian , He Yiming , Mebrahtu Chalachew , Zhou Qiaoqiao , Zhang Yuting , Wang Xuerui , Chen Huanhao , Zeng Feng , Gu Xuehong 
Published: August 2023

AbstractCo‐hydrogenation of CO2/CO to produce ethanol presents an important way to utilize carbon‐neutralized biomass resources through gasification. By applying a water‐permselective membrane reactor, water, the byproduct of CO2/CO hydrogenation to ethanol, can be removed. Thus, ethanol formation can be promoted thermodynamically. Accordingly, herein, the thermodynamics of ethanol synthesis by CO2, CO, CO2/CO hydrogenation was investigated, as well as the promoting effects of water removal under various temperatures and pressures by Aspen Plus. It is found that, at medium reaction temperature (e.g., 250 °C), medium pressure (e.g., 10–50 bar), and medium CO fraction (e.g., 0.1–0.5) together with 1‐stage water removal, a CO2/CO equilibrium conversion higher than 80 % can be obtained.
A Direct Route to Tetrahydropyridazine Derivatives via DMAP‐Catalyzed [4+2] Annulation of Allenoates with Arylazosulfones
Authors: Ji Xin , Li Ziyang , Zhang Jinfeng , Zhang Yicheng , Meng Ling‐Guo 
Published: August 2023

Comprehensive SummaryHerein, a DMAP‐catalyzed [4+2] annulation of α‐substituted allenoates with arylazosulfones is reported, which affords facile access to tetrahydropyridazine derivative in synthetically useful yields. This reaction features mild conditions and good functional group tolerance. Moreover, the resultant products can be readily transformed into pyridazin‐3‐one derivatives in the presence of DDQ.
LVAD therapy as a catalyst to heart failure remission and myocardial recovery
Authors: Hamad Eman A. , Byku Mirnela , Larson Sharon B. , Billia Filio 
Published: August 2023

AbstractThe management of chronic heart failure over the past decade has witnessed tremendous strides in medical optimization and device therapy including the use of left ventricular assist devices (LVAD). What we once thought of as irreversible damage to the myocardium is now demonstrating signs of reverse remodeling and recovery. Myocardial recovery on the structural, molecular, and hemodynamic level is necessary for sufficient recovery to withstand explant and achieve sustained recovery post‐LVAD. Guideline‐directed medical therapy and unloading have been shown to aid in recovery with the potential to successfully explant the LVAD. This review will summarize medical optimization, assessment for recovery, explant methodologies and outcomes post‐recovery with explant of durable LVAD.
Molybdenum‐Mediated Insertion of Ketones into the P−P bond of cyclo‐(P5Ph5) and Formation of Trinuclear Molybdenum Complexes
Authors: Gorbachuk Elena , Grell Toni , Khayarov Khasan , Buzyurova Daina , Ziganshin Marat , Mukhametzyanov Timur , Lapuk Semen , Hey‐Hawkins Evamarie , Sinyashin Oleg , Yakhvarov Dmitry 
Published: August 2023

AbstractThe reaction of cyclopentaphosphine cyclo‐(P5Ph5) (1) with ketones (acetone and cyclooctanone) in the presence of [Mo(CO)4(cod)] (cod=cycloocta‐1,5‐diene) led to air‐stable trinuclear complexes in which the bis‐phosphanido ligands (PPh−PPh−PPh−PPh−CMe2O−PPh)2− (complex 2) and (PPh−PPh−PPh−PPh−C(CH2)7O−PPh)2− (complex 3) bridge a Mo(CO)3−Mo(CO)3 unit. This extends the reaction of 1 with transition metal carbonyl complexes to further substrates and represents the first examples of insertion of carbonyl compounds into the P−P bond of cyclic oligophosphorus compounds. Complexes 2 and 3 have been characterized by 31P NMR spectroscopy and single crystal X‐ray diffraction. Furthermore, the thermal properties of the obtained complexes have been studied by differential scanning calorimetry (DSC) and fast scanning calorimetry (FSC).
Identification of key genes promoting stamen formation induced by silver nitrate in gynoecious melon
Authors: Dai Dongyang , Kexin Chen , Liu Yujing , Wang Jiayao , Ji Peng , Sheng Yunyan 
Published: August 2023

AbstractThe gynoecious melon shows a high degree of hybrid seed production advantage, and exploitation of this property could improve both seed production and breeding, as well as reduce labor costs in melon production. The mechanism responsible the formation of hermaphroditic flowers by exogenous AgNO3 spraying is unclear. In the present study, the gynoecious inbred melon line WI998 was treated with AgNO3 solution to produce hermaphrodite flowers. Seedlings were investigated at the two, three, four, and five true‐leaf stages, and the AgNO3 concentrations were 150, 300, 450, and 600 mg/L. We found that the optimum spray concentration of AgNO3 was 450 mg/L with an optimum application time at the four true leave‐leaf stage. Transcriptome sequencing was performed on four‐true‐leaf stage samples sprayed with 450 mg/L AgNO3 and water control to identify differentially expressed genes (DEGs). Twenty‐seven DEGs were identified and one, Cucumis melo epidermal pattern factor‐like protein 4 (CmEPFL4), was involved in stamen development gene. Phenotypic analysis showed that CmEPFL4 played a key role in stamen induction, and heterologous expression of CmEPFL4 was found to interfere with stamen development and reduce the amount of pollen produced. Overall, the results demonstrated the importance of CmEPFL4 in AgNO3‐induced hermaphroditic flower production and provide insight into AgNO3 induction of stamen formation in the melon.
Collective bulk excitations in the QGP: From the weakly non‐ideal case to the strong correlation limit
Authors: Baiseitov K. , Blaschke D. , Ramazanov T. S. 
Published: August 2023

AbstractCollective bulk excitation propagating in the medium of a quark‐gluon plasma are studied. The quark‐gluon plasma medium is described with two different models to investigate the effect of binary collisions and shear viscosity to account for damping and non‐ideality. To find the dispersion relation the longitudinal dielectric functions of the quark‐gluon plasma are used within quantum hydrodynamics and transport equation approaches. The results were obtained numerically by finding the roots of the dispersion relations. Both models are compared with the hard thermal loop approximation as the ideal case for both models.
Viral escape from NK‐cell‐mediated immunosurveillance: A lesson for cancer immunotherapy?
Authors: Momayyezi Pouria , Bilev Eleni , Ljunggren Hans‐Gustaf , Hammer Quirin 
Published: August 2023

AbstractNatural killer (NK) cells are innate lymphocytes that participate in immune responses against virus‐infected cells and tumors. As a countermeasure, viruses and tumors employ strategies to evade NK‐cell‐mediated immunosurveillance. In this review, we examine immune evasion strategies employed by viruses, focusing on examples from human CMV and severe acute respiratory syndrome coronavirus 2. We explore selected viral evasion mechanisms categorized into three classes: (1) providing ligands for the inhibitory receptor NKG2A, (2) downregulating ligands for the activating receptor NKG2D, and (3) inducing the immunosuppressive cytokine transforming growth factor (TGF)‐β. For each class, we draw parallels between immune evasion by viruses and tumors, reviewing potential opportunities for overcoming evasion in cancer therapy. We suggest that in‐depth investigations of host–pathogen interactions between viruses and NK cells will not only deepen our understanding of viral immune evasion but also shed light on how NK cells counter such evasion attempts. Thus, due to the parallels of immune evasion by viruses and tumors, we propose that insights gained from antiviral NK‐cell responses may serve as valuable lessons that can be leveraged for designing future cancer immunotherapies.
Highly Efficient Electrochemical Nitrate and Nitrogen Reduction to Ammonia under Ambient Conditions on Electrodeposited Cu‐Nanosphere Electrode
Authors: Truong Giang Binh , Duong Hung Tuan , Vu Loi Duc , Hoang Thao Thi Huong 
Published: August 2023

AbstractThe electrochemical reduction reaction of nitrogenous species such as NO3− (NO3RR) and N2 (NRR) is a promising strategy for producing ammonia under ambient conditions. However, low activity and poor selectivity of both NO3RR and NRR remain the biggest problem of all current electrocatalysts. In this work, we fabricated Cu‐nanosphere film with a high surface area and dominant with a Cu(200) facet by simple electrodeposition method. The Cu‐nanosphere film exhibits high electrocatalytic activity for NO3RR and NRR to ammonia under ambient conditions. In the nitrate environment, the Cu‐nanosphere electrode reduced NO3− to yield NH3 at a rate of 5.2 mg/h cm2, with a Faradaic efficiency of 85 % at −1.3 V. In the N2‐saturated environment, the Cu‐nanosphere electrode reduced N2 to yield NH3 with the highest yield rate of 16.2 μg/h cm2 at −0.5 V, and the highest NH3 Faradaic efficiency of 41.6 % at −0.4 V. Furthermore, the Cu‐nanosphere exhibits excellent stability with the NH3 yield rate, and the Faradaic efficiency remains stable after 10 consecutive cycles. Such high levels of NH3 yield, selectivity, and stability at low applied potential are among the best values currently reported in the literature.
Look me in the eyes! A preliminary study on eye‐contact in adolescents with anorexia nervosa
Authors: Nuding Laura , Lukas Linda , Platt Belinda , Schulte‐Körne Gerd , Sfärlea Anca 
Published: August 2023

AbstractObjectiveAnorexia nervosa (AN) is often associated with impairments in the socio‐emotional domain. Avoidance of eye‐contact may underlie some of these difficulties and has been found in adults with AN in several studies. This study aimed to clarify whether adolescents with AN also show reduced eye‐contact when viewing social stimuli, that is, faces.MethodsIn this cross‐sectional study, girls aged 12–18 years with AN (n = 38) were compared with a clinical (girls with depression and/or anxiety disorders; n = 30) and a healthy (n = 36) control group. Eye‐contact was operationalised as maintenance of visual attention to the eye‐area of faces showing different emotional expressions (happy, angry, afraid, sad, neutral), recorded via eye‐tracking.ResultsContrary to our expectations, we did not find adolescents with AN to dwell less on the eye‐area than control groups; instead, we found preliminary evidence for increased attention to the eye‐area in the AN group compared to the healthy control group.ConclusionsThe results suggest that reduced eye‐contact found in adult AN samples is not (yet) present in adolescents with AN but may develop with the prolonged duration of the disorder. However, replication and longitudinal studies are needed to confirm this assumption.
Dementia care navigation: A systematic review on different service types and their prevalence
Authors: Giebel Clarissa , Reilly Siobhan , Gabbay Mark , Dickinson Julie , Tetlow Hilary , Hogan Hayley , Griffiths Alys , Cooper Claudia 
Published: August 2023

AbstractBackgroundDementia Care Navigators (DCNs) are professionals without clinical training, who provide individualised emotional and practical support to people living with dementia, working alongside clinical services. Navigator services have been implemented but the service offered vary without a consistent overview provided. The aim of this narrative systematic review was to describe and compare existing service formats, and to synthesise evidence regarding their implementation and impacts.MethodsThe review was registered on PROSPERO [CRD42021292518]. Three electronic databases were searched and included studies reported on a DCN service, defined as a service in which non‐clinically trained workers provide personalised advice and support to people with dementia and/or carers in the community. Two independent reviewers screened abstracts and titles and read through full papers for inclusion. Risk of bias was assessed using the Standard Quality Assessment QualSyst.ResultsWe included 14 papers reporting on six studies. All services were US‐based and only varied by integration and training provided. Studies reported different degrees of impact on service utilisation and on symptoms and mental well‐being of people with dementia and their carers, with too little evidence to draw substantial/meaningful conclusions and studies employing different outcome measures. One study evidenced greater impacts on people with more advanced dementia compared to earlier stages.ConclusionsDCN services have the potential to effectively provide non‐clinical support to people with dementia and carers from the point of diagnosis. Further research from countries other than the USA, focusing on the impact on social care and social support service access and utilisation, and utilising similar established outcome measures are required.
Cumulative risk assessment for combinations of environmental and psychosocial stressors: A systematic review
Authors: Tong Ruipeng , Zhang Boling 
Published: August 2023

Abstract
With the growing awareness of stressors, cumulative risk assessment (CRA) has been proposed as a potential method to evaluate possible additive and synergistic effects of multiple stressors on human health, thus informing environmental regulation and protecting public health. However, CRA is still in its exploratory stage due to the lack of generally accepted quantitative approaches. It is an ideal time to summarize the existing progress to guide future research. To this end, a systematic review of the literature on CRA issues dealing with combinations of environmental and psychosocial stressors was conducted in this study. Using typology and bibliometric analysis, the body of knowledge, hot topics, and research gaps in this field were characterized. It was found that research topics and objectives mainly focus on qualitative analysis and community settings; more attention should be paid to the development of quantitative approaches and the inclusion of occupational settings. Further, the roles of air pollution and vulnerability factors in CRA have attracted the most attention. This study concludes with views on future prospects to promote theoretical and practical development in this field; specifically, CRA is a multifaceted topic that requires substantial collaborations with various stakeholders and substantial knowledge from multidisciplinary fields. This study presents an overall review as well as research directions worth investigating in this field, which provides a historical reference for future study. Integr Environ Assess Manag 2024;20:602–615. © 2023 SETAC