bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pan-Cancer Analysis Revealed ITM2A as a Predictive Biomarker of Prognosis and Immunotherapy for Kidney Renal Clear Cell Carcinoma
Authors: Zhang Hui , Fang Jin , Ruan Rongwei , Yu Jiangping , Wang Shi 
Published: August 2023

Abstract
Immunotherapies including the use of immune-checkpoint inhibitors or adoptive cellular transfer have revolutionized the efficacy of various malignancies. However, the identification of potential markers in pan-cancer and the underlying molecular mechanisms in the tumor microenvironment (TME) remain unclear. We evaluated the association of potential T-cell driver genes (TDGs) reported previously with pan-cancer and identified ITM2A was under-expressed in multiple cancers, suggesting a worse prognosis in Acute Myeloid Leukemia (LAML), Skin Cutaneous Melanoma (SKCM), Liver hepatocellular carcinoma (LIHC), Kidney renal clear cell carcinoma (KIRC), and Pancreatic adenocarcinoma (PAAD). Results of the single-cell analysis showed that ITM2A was significantly concentrated in T cells. Patients with low ITM2A had a worse prognosis, higher tumor stage, and grade, which could be an independent prognostic risk factor in KIRC. The abnormal regulation of ITM2A in KIRC was confirmed by immunohistochemistry. Further research suggested that ITM2A was positively correlated with immunomodulators, TIICs, immune checkpoints, TMB, and immune score in KIRC. The aberrant expression of ITM2A could predict the immunotherapy response of ICB in KIRC. In conclusion, as a driver gene of T cells, ITM2A may be a potential prognostic and immunological characteristic for KIRC.
Design of 3D printing osteotomy block for foot based on triply periodic minimal surface
Authors: Xie Haiqiong , Xie Haitao , Xu Wei , Yang Baiyin , Huang Chen , Liao Dongfa , Cui Lin , Xie Meiming 
Published: August 2023

Abstract
Introduction: The advantages of triply periodic minimal surfaces (TPMS) lie in their smooth surface and connected hFole height, while the overall structure is precisely controlled by implicit functions. This study was to explore the application of this method in designing and modeling porous structures for 3D printing of foot osteotomy blocks.
Methods: The TPMS for designing porous structures of G (Gyroid) and D (Diamond) structures was determined using Matlab R2020a based on implicit functions. Porous samples were prepared through EBM technology, and mechanical performance data were obtained by conducting mechanical testing on the samples. Comparative analysis was performed to identify the optimal porous structure for designing a bone block implant, and subsequently, the shaping design of the porous osteotomy block was completed based on the determined structure.
Results: The relative density exhibits a negative correlation with the variable parameters, and as the relative density decreased in a porous structure, its volume fraction also decreased. The optimal t values for the porous G and D structures were 0.61, 0.92, 1.22 and 0.49, 0.76, 1 respectively, corresponding to relative densities of 30%, 20%, and 10%. The G structure demonstrated a progressive collapse damage mechanism from bottom to top layer by layer, while the D structure exhibit a shear failure zone at a 45° angle which was not conducive to energy absorption and was more susceptible to brittle fracture compared to the G structure. In terms of stress-strain curve repeatability for porous samples with a unit size of 1.5 mm, the G structure showed strong consistency while there was significant deviation in samples with D structure. Among samples with the same unit size, those with a relative density of 30% in G structure possessed higher mechanical strength as well as larger elastic modulus compared to others. Although samples with a relative density of 20% did not exhibit as high mechanical strength as mentioned above counterparts did have lower elastic modulus and larger porosity rate instead. The designed foot osteotomy blocks can adjust aperture size and porosity rate of beam-like structures by modifying function parameters using aforementioned methods.
Conclusion: The foot osteotomy block's porous structure based on TPMS design, exhibits characteristics such as porosity, smoothness, and connectivity. This makes it an excellent method for preparing 3D printed specimens of foot osteotomy blocks.
Genetic Variability Analysis of Elite Sorghum (Sorghum Bicolor (L) Moench) Genotypes Under Dry Lowland Areas of Ethiopia
Authors: Begna Temesgen 
Published: August 2023

Abstract
Narrow genetic base and lack of potential drought resistant sorghum genotypes are the major limiting factors for sorghum yield improvement under moisture stress areas. Therefore, the experiment was conducted to quantify the genetic variation available among sorghum genotypes for drought tolerance. A total of 42 sorghum genotypes were evaluated using alpha lattice experimental design with two replications at Mieso and Kobo during the cropping season of 2019. The combined analyses of variance revealed the presence of substantial genetic variation among sorghum genotypes for all the studied traits. Among the traits with high genotypic coefficient of variation and heritability estimate, plant height, panicle exersion and panicle yield were linked with higher values of genetic advance as percentage of mean, reflecting the variability of these traits is controlled by additive gene action. The high heritability and genetic advance as percent of mean were obtained for plant height (95.63 and 45.39%), 1000 seed weight (77.98 and 23.86%), panicle exertion (74.87 and 51.88%), and panicle yield (65.43 and 37.32%) in the same order. The maximum grain yield was obtained from a hybrid 4x14 (6.32 tha− 1) followed by hybrid 8x15(5.92 tha− 1), 1x15 (5.88 tha− 1), 13x14 (5.78 tha− 1) and 6x15 (5.57 tha− 1) with the average value of 5.00 tha− 1 which had higher mean value than the mean of the parents and the check (ESH-4). In general, this study showed the existence of genetic variability in sorghum genotypes for different traits grown under moisture stress condition, providing opportunity to select several promising genotypes with key traits to drought tolerance.
An Ultra-wideband Antenna for Future mm-Wave Applications
Authors: Masood Asad , Nizam-Uddin N. 
Published: August 2023

Abstract
This paper introduces a planar ultra-wideband microstrip antenna tailored for millimeter-wave applications. The antenna effectively spans a considerable frequency range from 33.4 to 89.4 GHz. According to simulations, the antenna achieves a peak radiation efficiency of 88 percent, accompanied by a maximum gain of 7 dBi. The antenna design boasts a return loss that remains consistently below -10 dB. The antenna's architecture employs two vertical stubs, strategically employed to regulate the accessible bandwidth. Through optimization of the antenna structure, an impressive bandwidth of 56 GHz can be attained at maximum. The outcomes of the study indicate that the proposed antenna is excellently suited for various millimeter-wave applications, including Ka-band utilization (33.4-36 GHz), 5G cellular communication (33.4-39 GHz), IEEE 802.11ad high-speed wireless systems at 60 GHz, as well as the 57-66 GHz spectrum designated for IEEE 802.15 wireless personal area networks (WPANs).
Flexible Job shop Scheduling with the Parallelized Cuckoo Search Optimisation algorithm
Authors: Gupta Swati 
Published: August 2023

Abstract

A well-known combinatorial optimization problem known as the Flexible Job Shop Scheduling Problem (FJSP) often arises in engineering The complexity of the problem is complicated by the number of calculations required to find the optimal answer. In this work, we propose to use a parallel version of the Cuckoo Optimization Algorithm (COA) to solve the FJSP. Because parrots often lay their eggs in other birds’ nests, COA is a meta-heuristic optimization strategy. To increase speed, the proposed parallelized COA algorithm uses OpenMP to divide the computing workload among multiple processors. Benchmark examples taken from the literature are used to evaluate the performance of the proposed algorithm. The results show that, in terms of solution quality and computation time, the proposed method outperforms the current state-of-the-art methods
Sustainable commodity sourcing requires measuring and governing land use change at multiple scales
Authors: zu Ermgassen Erasmus , Renier Cécile , Carvalho Tomás , Garcia Andrea , Meyfroidt Patrick 
Published: August 2023

Abstract

Agricultural expansion is the driver of more than 90% of deforestation across the tropics, a major contributor to global greenhouse gas emissions. Thankfully, a number of new initiatives are emerging to both tackle deforestation and include it within the greenhouse gas emissions reporting of major importers and food companies. In May 2023, for example, the European Union approved a landmark due-diligence regulation on imported deforestation, and the World Business Council on Sustainable Development (WBCSD) is currently developing a harmonized approach for calculating scope 3 (i.e. supply chain) emissions, which includes emissions from deforestation and other land use change. These initiatives are critically important because they are agenda-setting, defining for years-to-come what success looks like for governments’ and companies’ efforts to reduce deforestation and carbon emissions.
Unfortunately, we believe that both these initiatives are making a fundamental yet avoidable mistake which risks undermining their effectiveness in addressing deforestation. Namely, both initiatives monitor compliance and success exclusively at the farm-scale. In this Opinions article, we pull together insights from the literature on land systems science and supply chain governance, and newly published data from Brazil from the Mapbiomas initiative, to make the case that in order to be successful, these initiatives must monitor compliance and success across multiple scales simultaneously, from farms to landscapes and administrative units.
Phenotyping wild potatoes (Solanum Sect. Petota) for photosynthesis associated traits under heat stress.
Authors: Bashir Ikram , Nicolao Rodrigo , Barros Willian Silva , Haerter Janni André , de Brito Giovani Greigh , Castro Caroline Marques , Heiden Gustavo 
Published: August 2023

Abstract

Heat stress is one of the major factors reducing potato yield by limiting the plant photosynthesis activity, production and partitioning of assimilates to the sink. Potato wild relatives (Solanum sect. Petota) are a natural reservoir of valuable traits for abiotic stress resistance. However, it is necessary to assess the response of wild potato genotypes based on physiological features such as gas exchange, chlorophyll index and chlorophyll fluorescence that are promising candidates to improve crop photosynthesis under adverse conditions. Multivariate approaches on two factor experimental design were used to select the best performing genotypes for most important traits influencing the photosynthetic activity under control and heat stress treatments. The most important traits to be focused on are net photosynthetic rates, transpiration rates, and stomatal conductance along with effective photochemical yield of PSII, Coefficient of photochemical yield of PSII, electron transport rate and Fv/Fm ratio which are highly associated with heat stress conditions. Solanum commersonii accessions (BGB003, BGB009) are more likely to be tolerant to heat stress, followed by S. tuberosum 2x (BGB091, BGB093) and S. chacoense (BGB101). The assessment of wild accessions for photosynthetic traits under heat stress is a reliable way to discriminate the most promising sources of abiotic stress resistance even though they have unreliable tuber traits for the breeding of the potato crop.
‘TESTAMENTUM PESTIS TEMPORE CONDITUM’
Authors: Sobczyk Marek 
Published: August 2023

Niniejszy artykuł poświęcony jest szczególnej formie testamentu uznanej w konstytucji Dioklecjana i Maksymiana w 290 r. (C. 6,23,8), nazywanej tradycyjnie testamentum pestis tempore conditum. Była to złagodzona co do wymogów forma testamentu, stosowana jedynie w czasie zarazy i mająca na względzie niebezpieczeństwo zarażenia się i związaną z tym obawę świadków testamentowych oraz dotykające testatora trudności w sporządzeniu testamentu. Uwagi na jej temat poprzedzam syntetyczną prezentacją zwyczajnych form testamentu znanych prawu rzymskiego, gdyż analizowana forma szczególna była tylko złagodzoną postacią zwyczajnej.
Stawiam dwa zasadnicze problemy: w jakich okolicznościach testamentum pestis tempore conditum było dopuszczalne i na czym polegało odstępstwo od zwyczajnej formy testamentu. Analizie poddaję terminy casus maior, morbo oppresso, morbo oppressos i iungi atque sociari. Niestety zwięzła treść reskryptu uniemożliwia precyzyjną i jednoznaczną odpowiedź na powyższe pytania.
W mojej ocenie testamentum pestis tempore conditum było stosowane, gdy dotknięty chorobą zakaźną testator sporządzał testament, przebywając w miejscowości, w której panowała zaraza o takim rozmiarach, które pozwalały uznać ją za siłę wyższą. Nie wystarczał tu zaś stan epidemii jako taki ani też choroba potencjalnego świadka testamentu, jeżeli testator pozostawał zdrowy. Złagodzenie wymogów formalnych testamentu polegało na tym, że świadkowie nie musieli składać swych pieczęci w bliskim kontakcie z chorym testatorem, jednakże czynność ta musiała odbyć się w obecności testatora, choć w pewnym dystansie od niego. Nie przekonują mnie zaś propozycje wykładni zakładające brak jakiejkolwiek styczności testatora ze świadkami podczas czynności sporządzania testamentu, zwłaszcza przyjmujące, że świadkowie składali swoje pieczęcie pod nieobecność testatora.
JURYŚCI JAKO KONSULTANCI WŁADZ W ŚREDNIOWIECZNYCH KOMUNACH WŁOSKICH
Authors: Szymańska Aleksandra 
Published: August 2023

Przedmiotem artykułu jest rola, jaką pełnili prawnicy w średniowiecznych miastach Italii, ich aktywność zawodowa oraz polityczna. Szczególny nacisk został położony na ich działalność interpretacyjną, doradczą oraz sporządzanie consilia dla urzędników komunalnych. Juryści wydawali oficjalne opinie prawne zarówno w sprawach sądowych administracyjnych, jak i politycznych. Ich porady były wykorzystywane do rozwiązywania problemów wynikających między innymi ze sprzecznych przepisów prawa statutowego oraz z ciągłych ich zmian, będących skutkiem rywalizacji pomiędzy instytucjami.
Novel Invasive Methods as the Third Pillar for the Treatment of Essential
Uncontrolled Hypertension
Authors: Tsioufis Panagiotis-Anastasios , Theofilis Panagiotis , Vlachakis Panayotis K. , Dimitriadis Kyriakos , Tousoulis Dimitris , Tsioufis Konstantinos 
Published: August 2023

Abstract:
Pharmacologic therapies remain the treatment of choice for patients with essential hypertension, as
endorsed by international guidelines. However, several cases warrant additional modalities, such as invasive antihypertensive
therapeutics. The major target of these interventions is the modulation of the sympathetic nervous
system, which is a common pathophysiologic mechanism in essential hypertension. In this narrative review,
we elaborate on the role of invasive antihypertensive treatments with a focus on renal denervation, stressing
their potential as well as the drawbacks that prevent their widespread implementation in everyday clinical
practice. In the field of renal denervation, several trials have shown significant and sustained reductions in the
level of office and ambulatory blood pressure, regardless of the type of energy that was used (radiofrequency or
ultrasound). Critically, renal denervation is considered a safe intervention, as evidenced by follow-up data from
large clinical trials. Baroreflex activation therapy may result in enhanced parasympathetic nervous system activation,
thus lowering blood pressure levels. Along the same lines, carotid body ablation could also produce a
significant antihypertensive effect, which has not been tested in appropriately designed randomized trials. Moreover,
cardiac neuromodulation therapy could prove efficacious by altering the duration of the atrioventricular interval
in order to regulate the preload of the left ventricle and, therefore, lower blood pressure.
The Effect of Coronavirus Pandemic on the Treatment of Gynecological
and Breast Cancers
Authors: Momenimovahed Zohre , Allahqoli Leila , Salehiniya Hamid 
Published: August 2023

Introduction:
During the COVID-19 pandemic, various groups, including women with cancer, were affected as a high-risk group in terms of disease diagnosis and treatment. Despite the importance of therapeutic changes in cancers, such as breast and gynecological cancer, there is no comprehensive study in this regard that also refers to the coronavirus. The need for a deep understanding of the impact of coronavirus on the treatment plan of this group of patients caused the researcher to design and implement this study that aims to investigate the treatment challenge among cancer patients during the COVID-19 pandemic.

Materials and methods:
To answer the study question, a comprehensive search was carried out in databases, such as PubMed, Web of Science Core Collection, and Scopus, using keywords, including cancer, gynecologic cancer, breast cancer, treatment, delay, and modification. Full-texted, English language and original articles were included in this study.

Results:
In total, 27 articles were selected for the study. The findings of this study revealed that COVID-19 greatly affects the treatment of gynecology and breast cancer. These patients experience delay or modification of cancer treatment. Increased time between diagnosis and treatment, delay, change or cancellation of surgery and change in treatment plan are the most important changes in cancer treatment during the COVID-19 pandemic.

Conclusion:
The COVID-19 pandemic has had a significant impact on various aspects of gynecology and breast cancer care worldwide. In the current pandemic, there has been a significant delay in the diagnosis and treatment of gynecological and breast cancer, which, due to its higher morbidity and mortality, has made the condition more difficult for cancer patients and treatment teams.
Evaluation of Expression Profile of Patients with Acute Myeloid Leukemia
in Response to Azacitidine with Biological System Approach
Authors: Hejab Rasta , Rahimi Hamzeh , Abedinlou Hamid , Ghoraeian Pegah 
Published: August 2023

Background:
Acute myeloid leukemia (AML) is a prevalent type of leukemia that is associat-ed with high rates of chemoresistance, including resistance to Azacitidine (AZA). Understanding the mo-lecular mechanisms of chemoresistance can lead to the development of novel therapeutic approaches. In this study, we aimed to identify dysregulated miRNAs and their target genes involved in chemoresistance to AZA in AML patients.

Methods:
and Findings: We analyzed expression profiles from two GEO datasets (GSE16625 and GSE77750) using the "Limma" package in R. We identified 29 differentially expressed miRNAs between AML patients treated with AZA and healthy individuals. MultiMiR package of R was used to predict tar-get genes of identified miRNAs, and functional enrichment analysis was performed using FunRich soft-ware. Protein-protein interaction networks were constructed using STRING and visualized using Cyto-scape. MiR-582 and miR-597 were the most up- and down-regulated miRNAs, respectively. Functional enrichment analysis revealed that metal ion binding, regulation of translation, and proteoglycan syndecan-mediated signaling events were the most enriched pathways. The tumor necrosis factor (TNF) gene was identified as a hub gene in the protein-protein interaction network.

Discussion:
Our study identified dysregulated miRNAs and their target genes in response to AZA treat-ment in AML patients. These findings provide insights into the molecular mechanisms of chemo-resistance and suggest potential therapeutic targets for the treatment of AML.

Conclusion:
Further experimental validation of the identified miRNAs and their targets is warranted.
Anatomical Structure and Histochemical Study Male Strobilus of Melinjo (Gnetum gnemon L.)
Authors: Eka Damayanti Wenni , Susanti Siti 
Published: August 2023

Melinjo (Gnetum gnemon L.) is a plant from the Gymnospermae has many benefit, one of them is the melinjo male strobilus which is used as a vegetable. In melinjo plants there are various kinds of secondary metabolite compounds, especially the organs of leaves, seeds and seed coats, so that apart from being used as food ingredient it can be used as traditional medicine. This study aims to determine the anatomical structure and content of secondary metabolites in melinjo male strobilus. Observations of anatomical structures were made using paraffin methods, and observations of secondary metabolite content used histochemical tests using reagents on slices of fresh preparations then observed with a light microscope and were documented using OptiLab. The results of the observations revealed that anatomical structure of the nodes and internodes at the base, middle, and tip does not revealed that there was structural differences that composed of epidermal tissue, parenchyma tissue, and vascular bundle with xylem and phloem, but there were differences in size that are getting smaller from the base to tip. The structure of the male flowers revealed that there were structural differences with differentiation from the tip to the base of the anther with increasingly size of the cells epidermal tissue, degradation of parenchyma tissue at the middle layer and tapetum, and pollen have been formed. Histochemical test at melinjo male strobilus contained secondary metabolites such as phenolics, terpenoids, flavonoids, alkaloids, and tannins.
Allometric model for height estimation of Alnus acuminata Kunth in agroecological zones of the high Andean tropics
Authors: Bacca-Acosta Pedro Pablo , Obando-Enriquez Bayron Giovanny , Lerma-Lasso Jose Libardo , Ortega-Cepeda María Camila , Palacio Manfred Ricardo , Zuluaga-Peláez John Jairo 
Published: August 2023

The complexity in the management of field tools for recording dasometric information has led to the use of allometric equations that save time, work, and costs allowing the estimation of variables that are difficult to record, such as total height (TH). The objective of this research was to develop an allometric equation for the species Alnus acuminata in order to calculate TH from the diameter at breast height (DBH). At the Obonuco-AGROSAVIA Research Center in Pasto (Nariño), dasometric information was recorded for 75 months for 200 even-aged trees. Four models were evaluated: linear, polynomial, Mixed linear (random effect per tree age), and Mixed linear (random effect per tree). For the selection of the best model, the criteria were used with the lowest values ​​of Akaike (AIC) and Bayesian (BIC). The information was analyzed using the "Nonlinear Mixed-Effects Models" package, R software. The results revealed that A. acuminata had an 81% survival; the TH average was 7.4 ± 1.3 m; and the average DBH was 9.51 ± 2.23cm. The average annual increase of DBH was 1.5 cm year-1, and the TH was 1.18 m∙ per year-1. The mixed linear model confirmed the assumptions of normality, independence, and homogeneity of variances in addition of having good criteria in its predictive performance and efficiency through the equation TH=2.07+0.35*DBH+0.95*Age. This research contributes to the management of native species of the high tropics by designing an equation for the first vegetative growth phases of A. acuminata in high mountain agroecological zones.