bluuebunny/crossref_metadata_2025_split huggingface dataset:
Training primary care staff in delivering the primary care consultation remotely: a systematic review
Authors: Parsons Jo , Salman Bilal , Leach Helen , Watson Eleanor , Atherton Helen 
Published: August 2023

BackgroundRemote consultation is widely used in primary care, and its use has increased greatly since the onset of the COVID-19 pandemic. Despite this, primary care clinicians lack formal training in delivering remote consultation. There is a need to understand how training might best be delivered, and what evidence there is to support this.AimTo summarise existing published literature about training primary care staff in conducting primary care consultation remotely, to outline which models of training may be effective, and to identify unanswered questions for future research.Design & settingSystematic review of English language studies in primary care included in Medline (Ovid), Cochrane Database, PubMed, Embase (Ovid), Web of Science, and CINAHL from 2010–2021; and in Google results from 2010–2022.MethodDatabases were searched using a predefined search strategy. Title, abstract, and full-text screening was conducted to identify eligible studies for inclusion in the review. The quality of included studies was assessed, and findings were synthesised to answer the research questions.ResultsWe included 10 studies. Seven examined training on remote consultation with trainee GPs or residents, and three examined training on remote consultation with qualified primary care clinicians. Training described led to positive change overall, including increased confidence and self-efficacy in delivering remote consultations. Furthermore, trainees reported increased use of remote consultation, increased efficiency, and increased engagement from patients. Studies where training involved workshops or didactic learning alongside experiential learning resulted in more positive feelings and more confidence about how technology could aid consultations.ConclusionThere is limited evidence on training primary care staff in conducting remote consultation. Available evidence indicates that training has a positive impact on the ability of clinicians and staff to deliver remote consultation.
Ancient Anchors showing Maritime History (Based on Tamil University Museum Evidence)
Authors: Raja A 
Published: August 2023

Anchors made of stone, wood or metal played a significant role in marine history. They have been used as protection material for ships in ports and as a means of establishing maritime relations with other countries. A variety of anchors used in passenger ships, cargo ships, and warships around the world have been discovered by marine researchers. Stone anchors were initially introduced in India and iron anchors after the arrival of the Europeans. Since then iron anchors have been developed and used in various parts of India. Ancient stone anchors and later iron anchors have been found especially on the east coast of Tamil Nadu. Such anchors are a testament to man’s maritime ability and knowledge in ancient times. Such anchors are on display at the Tamil University Museum, Thanjavur. In that sense this article describes the maritime technique and maritime history that the Tamils knew for commercial purposes in ancient times.
Arulmigu Ulagudaiya Amman Mulaippari Thiruvizha
Authors: Vimala Rani M , Rethineswari M 
Published: August 2023

Sivagangai District, Manamadurai Union of Periyakottai Village, The Presiding deity Arulmigu Ulagudaiya Amman Mulaippari Festival, is held by the Vellala community of Periyakottai.People of Periyakottai start preparation work for Mulaippari by collectingresidence tax. Then Dung collection, Sprouts collection, Sprouts soaking, Sprouts propagation process takes place in Mulaippari growing method. They conduct fun events like Kummi and Oyilattam during Mulaippari. Fasting for eight days and Picking Karagam up during the festival is not only an expression of devotion but also a basis of faith. The event of Mulaippari Thawing in Silamba River emphasizes the use of natural fertilizers for agriculture.
Life Problems of Diaspora: Introducing the Innovation of ‘Siam Death Train’...
Authors: Anantharajan G 
Published: August 2023

People have migrated throughout human history. It seems that the reasons for this migration have changed over time. Based on that, there have been successive migrations such as the Sangam migrations due to education, war and trade and the arrival of religious preachers. But literary works describing the problems faced by migrant Tamils in the workplace due to slavery and poverty and unemployment during the colonial period are rarely found. Notable among them is the novel ‘Siam Death Train’ which depicts the plight of Tamils taken for work. This novel changes it in the Tamil literature which only knows the migration of Eelam Tamils and highlights that Tamils migrated before the migration of Eelam Tamils and faced various problems and crises.
THE QUALITY OF MUSCLE TISSUE OF HEIFERS OF DIFFERENT GENOTYPES
Authors: Косилов В.И. , Миронова И.В. , Долженкова Г.М. , Хабибуллин И.М. , Алексеев О.В. 
Published: August 2023

В статье приводятся морфометрические показатели и выход мышечной ткани туши тёлок чёрно-пёстрой породы и её помесей первого и второго поколений с голштинами. При убое в 18 месяцев установлено, что чистопородные тёлки чёрно-пёстрой породы уступали помесным сверстницам по глубине длиннейшей мышцы спины на 3–9 мм (7,69–23,08%), её ширине – на 4–7 мм (5,06–8,86%), площади на поперечном разрезе – на 3,81–10,03 см2 (12,70–33,42%). В свою очередь помеси второго поколения превосходили помесей первого поколения по голштинам на 6 мм (14,29%), 3 мм (3,61%) и 6,22 см2 (18,39%) соответственно. Преимущество помесей над чистопородными сверстницами по массе мышечной ткани туши составляло 9,82–14,90 кг (6,48–9,83%), выходу мышечной ткани на 1 кг костей – 0,16–0,20 кг (4,11–5,14%), выходу мышечной ткани на 100 кг предубойной живой массы – 0,68–0,93 кг (1,72–2,35%). Причём лидирующее положение по этим показателям занимали помеси второго поколения. По соотношению мышечной и жировой ткани и соотношению жировой и мышечной туши существенных межгрупповых различий не отмечалось.
The article provides morphometric indicators and the yield of muscular tissue of the carcass of Black-and-White heifers and its crossbreeds of the first and second generations with Holsteins. When slaughtered at 18 months, it was established that Black-and-White heifers were inferior to crossbreed herdmates in depth of the longest muscle of the back by 3–9 mm (7.69–23.08%), its width – by 4–7 mm (5.06–8.86%), area on a cross-section – by 3.81–10.03 cm2 (12.70–33.42%). In turn, the second generation crossbreeds exceeded the first generation crossbreeds in Holstein by 6 mm (14.29%), 3 mm (3.61%) and 6.22 cm2 (18.39%), respectively. The advantage of crossbreeds over purebred herdmates in terms of carcass muscle tissue weight was 9.82–14.90 kg (6.48–9.83%), muscle tissue yield per 1 kg of bones was 0.16–0.20 kg (4.11–5.14%), muscle tissue yield per 100 kg of pre-slaughter live weight was 0.68–0.93 kg (1.72–2.35%). Moreover, the second generation crossbreeds occupied the leading position in these indicators. There were no significant intergroup differences by the ratio of muscle and adipose tissue.
Pengaruh Brand Experience, Affective Commitment , dan Brand Trust terhadap Brand Loyality pada Konsumen Cafe Ngopi Jo Manado
Authors: Kasiha Wisdom N. T. , Lumanauw Bode , Raintung Michael Ch. 
Published: August 2023

Penelitian ini bertujuan untuk mengetahuiPengaruh Brand Experience, Affective Commitment dan Brand Trust terhadap Brand Loyalty. Metode analisis yang digunakan adalah regresi linier berganda. Hasil penelitian menunjukan secara simultan brand experience, affective commitment dan brand trust berpengaruh signifikan terhadapbrand loyality, namun secara parsial affective commitmenttidak berpengaruh positif dan signifikan terhadap brandloyality. Untuk Ngopijo di Manado agar lebihmemperhatikan terkait faktor-faktor Brand Experience,Affective Commitmen, dan Brand trust yang ada sehingga dapat membuat konsumen menjadi lebih loyalterhadap brand yang mereka gunakan.
Kata Kunci: Brand experience, affective commitment, brandtrust, brand loyality
ANALISIS PENGARUH POTONGAN HARGA, CITRA MEREK, DAN KEPERCAYAAN PELANGGAN TERHADAP KEPUTUSAN PEMBELIAN DI ALFAMIDI KEC. TOBELO TENGAH
Authors: Simange Cimilivia , Tawas Hendra Novie , Roring Ferdy 
Published: August 2023

Persaingan semakin ketat akan membuat para pelaku bisnis menjadi lebih bersemangat dalam memberikan pelayanan yang baik terhadap konsumen, bertujuan untuk memberikan rasa puas terhadap pelanggan dan dapat memiliki daya saing dibandingkan kompetitor kualitas pelayananlah yang menjadi poin utama dalam menjalankan bisnis ritel saat ini. Penelitian ini bertujuan untuk menganalisi pengaruh Potongan Harga, Citra Merek dan Kepercayaan Pelanggan terhadap keputusan pembelian di Alfamidi Kec. Tobelo Tengah. Metode yang digunakan dalam penelitian ini adalah metode penelitian kuantitatif. Teknik pengunpulan data yang digunakan dalam penelitian berdasarkan kuesioner (angket). Dan untuk sampel yang digunakan dalam penelitian ini berjumlah 100 Responden melalui rumus Slovin Teknik analisis data menggunakan analias linear berganda dan uji t dan f dengan bantuan program SPSS versi 25. Hasil penelitian ini menunjukkan potongan harga tidak berpengaruh dan tidak signifikan terhadap keputusan pembelian, namun citra merek berpengaruh positif dan signifikan terhadap keputusan pembelian, begitu halnya dengan kepercayaan pelannggan berpengaruh positif dan signifikan terhadap keputusan, Ketiga variabel yaitu Potongan Harga , Citra Merek dan Keperyaan Pelanggan secara parsial dan simultan atau bersama-sama dapat memberikan pengaruh positif dan signifikan terhadap keputusan pembelian pada Alfamidi Kec. Tabelo Tengah.

Kata Kunci: potongan harga, citra merek, kepercayaan pelanggan, keputusan pembelian
PENINGKATAN PEMAHAMAN KONSEP MELALUI MODEL THINK PAIR SHARE DENGAN MEDIA KAREN (KARTU PERUBAHAN ENERGI)
Authors: Fadhaliva Maulida , Sekar Dwi Ardianti  , Much Arsyad Fardani  
Published: August 2023

Tujuan penelitian ini adalah untuk mendeskripsikan peningkatan pemahaman konsep siswa dalam penerapan model Think Pair Share menggunakan media KAREN (Kartu Perubahan Energi). Metode yang digunakan dalam peelitian ini adalah penelitian tindakan kelas. Teknik pengumpulan data dalam penelitian ini meliputi teknik wawancara, observasi, dokumentasi dan tes. Sedangkan teknik analisis data yang digunakan yaitu data kuantitatif dan data kualitatif. Hasil dari penelitian ini yaitu tingkat pemahaman konsep siswa pada tahap pra siklus memperoleh nilai rata-rata 71,46 dengan ketuntasan klasikal sebesar 38,46% (5 siswa). Kemudian pada siklus I memperoleh nilai rata-rata 65,23 dengan persentase ketuntasan klasikal 46,15%. Dari tahap pra siklus ke siklus I mengalami peningkatan sebesar 7,69%. Penelitian ini kemudian dilanjutkan pada siklus II, tingkat pemahaman konsep siswa pada siklus II memperoleh nilai rata-rata 80,92 dengan persentase ketuntasan klasikal 76,92%. Pada tahap siklus I ke siklus II telah mengalami peningkatan yang signifikan yaitu sebesar 30,77%. Hasil penelitian ini menunjukkan bahwa penerapan Think Pair Share menggunakan media KAREN (Kartu Perubahan Energi) dapat meningkatkan keterampilan mengajar dan pemahaman konsep guru pada siswa kelas IV SDN 3 Padurenan.
PEMANFAATAN BAHAN ALAM PADA MATA PEMBELAJARAN SBDP SEBAGI MEDIA BERKARYA KOLASE DI SD NEGERI 1 PARITTIGA
Authors: Robert Budi Laksana  , Negi  , Treny Hera  
Published: August 2023

ABSTRAC
The purpose of this study was to describe the use of natural materials in SBdP learning subjects as a medium for creating collages at SD Negeri 1 Parittiga. The method used in this research is descriptive qualitative with data analysis techniques. Where the data collected will be re-analyzed, the purpose of the analysis is to find out the use of natural materials used as a medium for making class IV B collage art which can be seen from the results of the collage art that has been made by students. In this study, data collection techniques used interviews, observation, and documentation. Utilization of this natural material can be used as a medium for making collage art seen from the skills of students attaching natural materials to seashells, student creativity and the form of collages that students make so that they can produce interesting collage art. This is evidenced by the results of student learning included in the good category in achieving KKM.
Keywords: Natural materials, Collage, Learning Outcomes.

ABSTRAK

Tujuan penelitian ini untuk mendeskripsikan pemanfaatan bahan alam pada mata pembelajaraan SBdP sebagai media berkarya kolase di SD Negeri 1 Parittiga. Metode yang digunakan dalam penelitian ini adalah deskriptif kualitatif dengan teknik analisis data. Dimana data yang di kumpulkan akan di analisis kembali, tujuan dari analisis tersebut adalah untuk mengetahui pemanfaatan bahan alam yang di gunakan sebagai media membuat karya seni kolase kelas IV B yang dapat di lihat dari hasil karya seni kolase yang telah di buat oleh siswa. Pada penelitian ini teknik pengumpulan data menggunakan wawancara, observasi, dan dokumentasi. Pemanfaatan bahan alam ini dapat di gunakan sebagai salah satu media untuk membuat karya seni kolase dilihat dari keterampilan siswa menempelkan bahan alam cangkang kerang, kreativitas siswa dan bentuk kolase yang siswa buat sehingga dapat menghasilkan karya seni kolase yang menarik. Hal ini dibuktikan dari hasil belajar siswa masuk dalam kategori baik dalam mencapai KKM.
Kata Kunci : Bahan alam, Kolase, Hasil belajar.
ANALISIS KESULITAN BELAJAR PESERTA DIDIK DENGAN KEMAMPUAN LITERASI RENDAH (Studi kasus kesulitan belajar akademik di kelas V SDN Cibaregbeg Semester Gasal Tahun Ajaran 2021/2022)
Authors: Yunira Putri Pangestu  
Published: August 2023

This research uses case study research with a qualitative approach. The purpose of this study was to determine the learning difficulties of students with low literacy skills at SDN Cibaregbeg, Sukabumi Regency in 2021/2022. The subject studied in this study was one of the students in the fifth grade at SDN Cibaregbeg, Sukabumi Regency. Data collection and data recording were carried out through procedures such as observation, interviews, and documentation. The data analysis technique used in this study is the data reduction, data presentation, and verification (conclusion) stages. To obtain the results of the study which looked at the learning difficulties of students with low literacy skills at SDN Cibaregbeg, the researchers used credibility, transferability, dependability, and confirmability tests which showed that the factors causing learning difficulties in students with low literacy skills were internal and external factors. Students do not have good learning motivation and have low interest in reading so that students experience learning difficulties, especially in learning to read. Efforts that can be made to deal with the problem of learning difficulties is to encourage students to study regularly both at home and at school. Another thing that can be done is to motivate students not to forget the benefits of learning by providing interesting learning.
Standardized Uptake Value (SUVmax) in Organ Confined Prostate Cancer in 68-Ga-PSMA PET-CT Scan and its Correlation with Prostate Specific Antigen level and Gleason Score
Authors: Ali Haider , Rashid-ul- Amin Syed , Hai Abdul 
Published: August 2023

Introduction: A positron emission tomography (PET) scan and a computed tomography (CT) scan is an integral part of oncological imaging, and other modalities like magnetic resonance imaging, CT or bone scintigraphy have some limitations in staging the workup of prostate carcinoma. Combined with tissue-specific markers like PSMA (prostate-specific membrane antigen), positron emitter-based functional imaging results have improved. Our study aimed to determine the Standardized Uptake Value (SUVmax) in prostate adenocarcinoma that is confined to the organ in Ga-68-PSMA PET-CT scans and how it correlates with prostate-specific antigen (PSA) levels and Gleason Score (GS). Materials and Methods: This cross-sectional study was conducted at SIUT (Sindh Institute of Urology and Transplantation), Karachi, and includes subjects referred for a Ga68-PSMA PET-CT scan from September 2017 to January 2022. Histopathologic-proven adenocarcinoma prostate patients with organ-confined disease and PSA levels obtained within six weeks before the PSMA-PET-CT scan were included in the study. PET-CT images were semi-quantitatively analyzed by measuring SUVmax, and the result was interpreted using statistical software SPSS version 22.0. Results: A total of 154 patients were analyzed. The mean age of patients was 66.57 ± 8.86 years. The GS of all patients ranges from 6 to 10. The mean and median PSA levels were 32.33 ng/ml (range: 0.004-306.00) and 14.20 ng/ml, respectively. The mean SUVmax of all prostatic lesions was 14.67±12.58, and the median value was 10.76. SUVmax was higher in patients with a PSA level of more than ten than those with a <10. The correlation of SUVmax with PSA and GS showed a significant correlation. Conclusion: The SUVmax of organ-confined prostate cancer correlates well with PSA level, and GS Median SUVmax and PSA directly relate to GS.
Fresh, hardened and durability properties of sodium carbonate-activated Algerian slag exposed to sulfate and acid attacks
Authors: Kahlouche R. , Badaoui A. , Criado M. 
Published: August 2023

This paper investigates the use of Na2CO3 as an alkaline activator on the durability of the alkali-activated slag (AAS) mortar toward sulfates and acids. The behavior of this binder in these aggressive environments is compared to those of slags activated with Na2SiO3 and NaOH. In addition, the setting times, workabilities, mechanical properties and drying shrinkage were evaluated. The AAS had superior workabilities, faster setting times and higher shrinkage rates than the Portland cement (PC). Increases in the activator dosages had positive effects on the mechanical strengths of the materials. Na2SiO3 was the best activator in terms of strength development, but it led to much higher shrinkage. The AAS showed less expansion and lower weight losses than the PC when exposed to sulfate and acids, respectively. The Na2CO3-AAS exhibited less shrinkage and higher resistance to sulfuric acid than the other activators, but the mechanical strength seen at early ages was low.
Discovery and characterization of cross-reactive single-domain antibodies targeting key virulence factors of Salmonella and Shigella
Authors: Ochoa Mark Anthony , Schmidt Hayden R 
Published: August 2023

Abstract

Study Objective
Here, we utilize a nanobody yeast display library to identify nanobodies that target virulence factors in Shigella spp. and Salmonella enterica typhimurium and determine if these nanobodies (Nbs) can inhibit host cell invasion in vitro.

Brief Statement of Methods
Using a synthetic yeast display library containing camelid Nbs with randomized CDR loops, we selected for binders to select Enterobacteriaceae virulence proteins, including IpaD/SipD, IcsA, and IcsP by MACS and FACS. Lead Nbs were cloned and expressed as monomeric VHH domains or Nb-Fc fusions. ELISA and flow cytometry surface staining was used to estimate affinity, and functional activity was assayed via a host cell invasion assay with Shigella flexneri, Shigella sonnei, and Salmonella enterica typhimurium.

Summary of Results
Several high affinity Nbs were isolated with specificity for the targe proteins, and a subset of these could bind whole bacterial cells. Lead Nbs were binned into epitopes by competitive binding assays. The efficacy of Nbs against specific epitopes of specific virulence proteins in invasion assays were directly compared.

Statement of Conclusions
A direct comparison of high-affinity Nb binders against various epitopes of IpaD/SipD, IcsA, and IcsP reveals that only a subset of epitopes are accessible on whole bacteria and able to inhibit bacterial invasion. These results will inform the development of virulence factor-based vaccines or other immunotherapies.
Wellcome Trust (REISTANT Consortium)
Fishing for novel dengue broadly neutralizing antibodies
Authors: Lowman Kelsey Elizabeth , Johnston Tim , Aogo Rosemary A , Thiono Devina , Mpingabo Patrick , Henry Amy R , Robert-Torres Jesmine , Estrada Luis , Lima Noemia Santana , de Silva Aravinda M , Douek Daniel , Katzelnick Leah 
Published: August 2023

Abstract
Due to a patent filing, the content of this abstract is not available to be shared at this time. The abstract will be shared at the poster session.
This work was supported by the Intramural Research Program of the National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health.
Development of a potent and infection-resistant anti-HIV CAR-T cells therapy
Authors: Lou Yaoxian , He Xiuting , Li Guangming , Su Lishan 
Published: August 2023

Abstract
Acquired immune deficiency syndrome (AIDS) caused by HIV infection is a serious global public health issue. The current combined antiretroviral therapy (ART) effectively controls HIV replication but fails to eliminate HIV reservoir cells, which allows a persistent viral infection. HIV-specific chimeric antigen receptor (CAR) T-cells have been designed to eliminate HIV-infected cells. The broad anti-viral activity, resistance to HIV infection and immune suppressive microenvironment determine a successful CAR-T therapy for HIV infection. In this study, we developed a potent CD4-based CAR-T cell with herpes virus entry mediator (HVEM) costimulatory domain. We intruded a S60C mutation in CD4 extracellular domain, which mediates a higher binding affinity to HIV envelope glycoprotein gp120 while preventes gp41-induced fusion between viral envelope and cell membrane. We demonstrated that CD4-based CAR-T cells bearing this 2C mutation were resistant to HIV infection. In addition, the HVEM costimulatory domain (CSD) mediated a superior effector T cell function than CD28 or 4-1BB-derived CSD did in CAR-T cells, showed by either cytotoxicity effect or cytokines response in contact with the HIV Envelope-transduced K562 cells in vitro. Furthermore, HVEM-CAR-T showed a better therapeutic efficacy than CD28 or 4-1BB CAR-T in humanized mouse model in vivo. Overall, we designed and developed a potent infection-resistant anti-HIV CAR-T cell by incorporating a mutant CD4 extracellular domain and HVEM-derived CSD.