bluuebunny/crossref_metadata_2025_split huggingface dataset:
EFFECTIVENESS OF CASIRIVIMAB-IMDEVIMAB AND SOTROVIMAB MONOCLONAL ANTIBODY TREATMENT AMONG HIGH-RISK PATIENTS WITH SARS-CoV-2 INFECTION: A REAL-WORLD EXPERIENCE
Authors: Murugapandian Sangeetha , Gungor Ahmet B. , Al-Obaidi Mohanad , Thajudeen Bijin , Wong Ryan C. , Mansour Iyad , Zangeneh Tirdad T. , Johnson Katherine M. , Low-Adegbija Nicole E. , Alam Ruhaniyah , Gonzalez-Negrete Elvira , Sandıkçı Burhaneddin , Gupta Gaurav , Bedrick Edward J. , Saridogan Turcin , Mendoza Katherine , Tanriover Bekir 
Published: December 2022

ABSTRACTBACKGROUNDSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can evade neutralizing antibodies, raising concerns about the effectiveness of anti-spike monoclonal antibodies (mAb).METHODSThis study reports a retrospective data analysis in Banner Health Care System. Out of 109,788 adult patients who tested positive for COVID-19, the study cohort was split into patients who received Casirivimab-Imdevimab (Cas-Imd) (N=10,836; Delta-predominant period 6/2021-11/2021) and Sotrovimab (N=998; Omicron-predominant period 12/2021-1/2022) mAb compared to propensity-matched control groups (N=10,836 and N=998), respectively. Index date was the date of mAb administration or the date of positive COVID-19 testing. The primary and secondary outcomes were the incidence of composite outcome (all-cause hospitalization and/or mortality) and ICU admission at 30-days following index date, respectively.RESULTSCompared to the propensity-matched untreated control cohort, the Cas-Imd mAb reduced the composite outcome (from 7.5% to 3.7%; difference: -3.8% [95% CI: (-4.4%, -3.2%)], p <0.01) regardless of their vaccination status, while Sotrovimab mAb did not (5.0% vs. 3.8%; difference: -1.2% [95% CI: (-3.1%, 0.7%)], p =0.22). In terms of the secondary outcome, similarly Cas-Imd mAb decreased ICU admission during the first hospitalization (from 1.5% to 0.5%; difference: -1.0% [95% CI: (-1.3%, -0.7%)], p <0.01) compared to the control group, whereas Sotrovimab mAb did not (0.9% vs. 0.6%; difference: -0.3% [95% CI: (-1.2%, 0.6%)], p =0.61). Comparing the periods, the Omicron-predominant period was associated with lower composite outcome than that during the Delta-predominant period.CONCLUSIONSCas-Imd mAb was effective against the SARS-CoV-2 Delta variant, however sotrovimab lacked efficacy in patients with SARS-CoV-2 Omicron-predominant period.Key PointsThis retrospective propensity matched analysis showed that treatment with Cas-Imd mAb was effective against the SARS-CoV-2 Delta variant to reduce the all-cause hospitalization and mortality within 30 days, by contrast sotrovimab mAb utilization lacked the efficacy against SARS-CoV-2 Omicron variant.
Techniques for Developing Reliable Machine Learning Classifiers Applied to Understanding and Predicting Protein:Protein Interaction Hot Spots
Authors: Chen Jiaxing , Kuhn Leslie A. , Raschka Sebastian 
Published: December 2022

AbstractWith machine learning now transforming the sciences, successful prediction of biological structure or activity is mainly limited by the extent and quality of data available for training, the astute choice of features for prediction, and thorough assessment of the robustness of prediction on a variety of new cases. Here we address these issues while developing and sharing protocols to build a robust dataset and rigorously compare several predictive classifiers using the opensource Python machine learning library, scikit-learn. We show how to evaluate whether enough data has been used for training and whether the classifier has been overfit to training data. The most telling experiment is 500-fold repartitioning of the training and test sets, followed by prediction, which gives a good indication of whether a classifier performs consistently well on different datasets. An intuitive method is used to quantify which features are most important for correct prediction.The resulting well-trained classifier,hotspotter, can robustly predict the small subset of amino acid residues on the surface of a protein that are energetically most important for binding a protein partner: the interaction hot spots.Hotspotterhas been trained and tested here on a curated dataset assembled from 1,046 non-redundant alanine scanning mutation sites with experimentally measured change in binding free energy values from 97 different protein complexes; this dataset is available to download. The accessible surface area of the wild-type residue at a given site and its degree of evolutionary conservation proved the most important features to identify hot spots. A variant classifier was trained and validated for proteins where only the amino acid sequence is available, augmented by secondary structure assignment. This version ofhotspotterrequiring fewer features is almost as robust as the structure-based classifier. Application to the ACE2 receptor, which mediates COVID-19 virus entry into human cells, identified the critical hot spot triad of ACE2 residues at the center of the small interface with the CoV-2 spike protein.Hotspotterresults can be used to guide the strategic design of protein interfaces and ligands and also to identify likely interfacial residues for protein:protein docking.
Coproduction in evaluating a dual diagnosis tool with youth in a residential mental health service
Authors: Kroes Simon , Myers Kevan , McLoughlan Grace , O'Connor Sarah , Keily Erin , Petrakis Melissa 
Published: December 2022

Purpose
The purpose of this study was to utilise a lived experience (LE) informed/co-designed approach to explore the service-user experience of using the reasons for use package (RFUP) within a youth residential rehabilitation mental health setting.

Design/methodology/approach
LE researchers (those who have lived through mental illness or distress), Master of social work students, a community of mental health service manager, community of mental health researchers, dual diagnosis service researchers and university-based researchers collaborated on the project. The study used an exploratory, qualitative approach of semi-structured interviews to invite young people's experiences of the resource. The research team conducted a collaborative thematic analysis drawing on the range of perspectives.

Findings
Through five interviews with young people, key themes identified included: client factors and extra-therapeutic events, relationship factors, technique/model factors/delivery and outcomes/things noticed.

Practical implications
The RFUP was a useful clinical tool with the young people in this pilot as it improved awareness of reasons for drug use and impact on mental health, service user to staff relationship, quality of the resource, mode of delivery and participant self-knowledge.

Originality/value
Young people valued the supportive role that the RFUP played in facilitating positive relationships with their workers.
Food discourse: ethics and aesthetics on Instagram
Authors: Irimiás Anna Rita , Volo Serena 
Published: December 2022

PurposeThe aim of the study is threefold: understanding the interconnections amongst visual and verbal multimodal communication strategies used in food discourse; identifying the themes of celebrity chef's food discourse with respect to pro-environmental behaviour; and providing a methodological framework to visually analyse food-themed videos.Design/methodology/approachThis study uses mise-en-scène and critical discourse and multimodal analyses to gain insights on food discourse from 20 videos shared by a Michelin starred chef on social media platforms.FindingsResults show that a pro-environmental cooking philosophy challenges the normative discourse on food and educates general audiences and foodies alike. Mise-en-scène and discourse analyses of Instagram visual content reveal that leftovers are central to the ethical message and are intertwined – through the aesthetic of the videos-with concepts of inclusivity, diversity and nourishment.Practical implicationsChefs, and restaurants, are encouraged to recognise their responsibility as role models, thus able to influence the societal production of food discourse.Originality/valueThe findings provide new insights into the role of a celebrity chef in promoting sustainable food preparation and consumption.
Plagiarism conundrum in Kenyan universities: an impediment to quality research
Authors: Nakitare Joel , Otike Fredrick 
Published: December 2022

Purpose
Plagiarism has been on the rise, mainly because of increased access to the internet and digital sources. To combat the threat of plagiarism, various universities have implemented countermeasures such as capacity building, anti-plagiarism policies and the purchase of anti-plagiarism software. In Kenya, there appears to be a lack of cohesion among universities in combating plagiarism, a situation that threatens teaching, learning and research if not addressed adequately. This paper aims to review and identify anti-plagiarism practices in Kenyan universities; it further proposed various best practices and policy actions that ought to be adopted to win the fight and the misperception of plagiarism.

Design/methodology/approach
This study adopted a mixed-method approach by surveying the librarians and interviewing the graduate school directors or deans to establish the strength and challenges in implementing plagiarism measures in the universities in Kenya. Before collecting data, the researcher checked the reliability of the tools by pretesting and readjusting the tools based on input from the participants.

Findings
This study established that most universities in Kenya appreciate the fact that plagiarism negatively affects the quality of teaching, learning and research. However, despite the fact that there is goodwill in the effort to combat plagiarism, there were no unified mechanisms, strategies and implementation policies in solving plagiarism issues among universities in Kenya. Different universities have adopted different strategies in terms of policy, software and capacity. Further, it was noted that the well-established/funded universities had clear stipulated mechanisms as opposed to the ill-funded universities with limited funding and budget.

Practical implications
This research provides an opportunity for universities to make an informed choice about the policies, required capacity and software to tackle plagiarism. The findings from the study will be used to improve the quality of academic writing and standardize procedures on plagiarism by proposing policy actions needed to maximize the benefits of the investments in this venture. This study recommends a collaborations approach among universities in the fight against plagiarism. Because the Kenya Library and Information Services Consortium already supports many university cooperation, they ought to take the initiative in formulating policy, choosing the appropriate software to use and developing the necessary ability in the battle against plagiarism.

Originality/value
To the best of the authors’ knowledge, this study is the first effort to evaluate the anti-plagiarism strategies being applied in different universities in Kenya. This study demonstrates the gaps and variations in university strategies in combating academic plagiarism. The findings can be applied to improve academic communication and indeed the quality of research output at other universities in Kenya and beyond.
Conceptual cost estimation of highway bid items – A systematic literature review
Authors: Awuku Bright , Asa Eric , Baffoe-Twum Edmund , Essegbey Adikie 
Published: December 2022

PurposeChallenges associated with ensuring the accuracy and reliability of cost estimation of highway construction bid items are of significant interest to state highway transportation agencies. Even with the existing research undertaken on the subject, the problem of inaccurate estimation of highway bid items still exists. This paper aims to assess the accuracy of the cost estimation methods employed in the selected studies to provide insights into how well they perform empirically. Additionally, this research seeks to identify, synthesize and assess the impact of the factors affecting highway unit prices because they affect the total cost of highway construction costs.Design/methodology/approachThis paper systematically searched, selected and reviewed 105 papers from Scopus, Google Scholar, American Society of Civil Engineers (ASCE), Transportation Research Board (TRB) and Science Direct (SD) on conceptual cost estimation of highway bid items. This study used content and nonparametric statistical analyses to determine research trends, identify, categorize the factors influencing highway unit prices and assess the combined performance of conceptual cost prediction models.FindingsFindings from the trend analysis showed that between 1983 and 2019 North America, Asia, Europe and the Middle East contributed the most to improving highway cost estimation research. Aggregating the quantitative results and weighting the findings using each study's sample size revealed that the average error between the actual and the estimated project costs of Monte-Carlo simulation models (5.49%) performed better compared to the Bayesian model (5.95%), support vector machines (6.03%), case-based reasoning (11.69%), artificial neural networks (12.62%) and regression models (13.96%). This paper identified 41 factors and was grouped into three categories, namely: (1) factors relating to project characteristics; (2) organizational factors and (3) estimate factors based on the common classification used in the selected papers. The mean ranking analysis showed that most of the selected papers used project-specific factors more when estimating highway construction bid items than the other factors.Originality/valueThis paper contributes to the body of knowledge by analyzing and comparing the performance of highway cost estimation models, identifying and categorizing a comprehensive list of cost drivers to stimulate future studies in improving highway construction cost estimates.
Effect of innovative practices on the growth of quantity surveying firms in Nigeria
Authors: Famakin Ibukun Oluwadara , Moyanga Dorcas Titilayo , Agboola Ajoke Aminat 
Published: December 2022

Purpose
Although the overall impacts of innovation and innovative practices have been emphasized in recent years, the effect on the growth of firms in Nigeria have not been proven. Therefore, this study aims to investigate the effect of innovative practices on the growth of quantity surveying firms (QSFs) in Nigeria.

Design/methodology/approach
The study adopted the quantitative correlational research design in which a well-structured questionnaire was used to collect data from QSFs in South-West, Nigeria. The data were analyzed using descriptive statistics and multiple regression analysis to investigate the effect of innovative practices on the growth of QSFs.

Findings
The study reveals that there is a significant increase in the growth indices used for assessing QSFs, while all the innovation variables were found to be reliable. Based on the result of multiple regression analysis, the relationships were identified as follows: quantity surveying (QS) software influenced the size growth of QSFs; QS software and services affected client growth and profit growth; and all innovation practices impacted asset growth of QSFs.

Practical implications
Although the use of software tools has been found to negatively affect the size of QSFs and other growth indices, there is need for them to embrace innovative software applications for more quality service delivery. In addition, QSFs should formulate strategic objectives that will guide them in taking informed decisions for diversification.

Originality/value
The outcome of this study provides information and direction for innovation practices required to bring about the growth of QSFs.
The influence of lean thinking on philanthropic organisations' disaster response processes
Authors: Mogotsi Keratiloe , Saruchera Fanny 
Published: December 2022

PurposeThis paper aims to reveal the philanthropy landscape processes for dealing with disasters and examine the influence of lean thinking in managing philanthropy for disasters. It sought to leverage continuous improvement and maximise disaster response and humanitarian logistics efficiency.Design/methodology/approachA sequential quantitative, qualitative research methods strategy was utilised involving data collection with literary analysis and two sets of online surveys with 212 NGO staff members in Malawi, Mozambique, South Africa and Zimbabwe. In addition, in-depth key informant interviews were conducted with 23 staff members at various management levels from these countries.FindingsThe study found that lean thinking had a positive, statistically valid influence at a 95% confidence level. Community incorporation, government support and collaboration with other philanthropic organisations were critical success factors. When lean thinking tools were applied (any tools), philanthropic organisations experienced waste reduction and value addition, where waste reduction accounted for 67% variation, and value-addition accounted for 58%, respectively. These were the same benefits experienced in other industries, thus, justifying lean thinking's applicability in the non-profit sector. Lean was most helpful about the communication and duplication of efforts challenges humanitarian or philanthropic organisations face when responding to a disaster.Practical implicationsThe study equips leaders and philanthropic organisations with suggestions to manage and respond to disasters in a lean and effective manner. The study helps philanthropy leaders rethink their funding and response models to pursue lean policies catering to humanitarian organisations and the communities they serve.Originality/valueThe study closes significant gaps in the literature and practice by adopting a multi-sectoral lens that borrows from business and manufacturing tools into a non-profit context. It enables documentation of processes and logistical management by philanthropy organisations for continuous improvement and elimination of waste to ensure efficiency in the philanthropic role of alleviating the impact of disasters. The study also affirms the need for philanthropic organisations to incorporate community feedback, use lean tools to collaborate with other responding organisations and work closely with the local authorities to fulfil the government's supportive role: the primary source and executor in disaster response.
Does shared leadership always work? A state-of-the-art review and future prospects
Authors: Chen Wei , Zhang Jun-Hui 
Published: December 2022

PurposeThe purpose of this study is to sort out the potential dark sides of shared leadership so as to promote a more comprehensive and balanced views of the impact of shared leadership and provide directions for future research.Design/methodology/approachThrough extensive database and manual searches, 766 literature records were obtained. After three rounds of literature screening, 17 studies were retained. On this basis, the 17 studies were coded and analyzed.FindingsFrom the perspectives of individual motivation, hierarchical functionalism and leadership role configuration, the existing studies have explored the negative impacts of shared leadership on team members, formal team leaders and the overall work teams. Specifically, for team members, shared leadership may cause negative consequences like power struggle, role stress and knowledge hiding. For formal team leaders, shared leadership may cause negative consequences like psychological territorial loss, leadership motivation declines and the dualistic paradox of self and group. For the overall work teams, shared leadership may cause negative consequences like team performance inhibition, low decision-making efficiency, team responsibility dispersion and team creativity decline. Meanwhile, contextual factors play a key role in determining the effects of shared leadership.Originality/valueThrough a systematic review of the negative impact of shared leadership, this study responds to the research calls for exploring the dark sides of shared leadership, provides the academic community with a more comprehensive and balanced view of the impact of shared leadership and identifies several directions for future research.
How hospital top managers reason about the central leadership task of balancing quality of patient care, economy and professionals’ engagement: an interview study
Authors: Bååthe Fredrik , von Knorring Mia , Isaksson-Rø Karin 
Published: December 2022

Purpose
This study aims to deepen the understanding of how top managers reason about handling the relationships between quality of patient care, economy and professionals’ engagement.

Design/methodology/approach
Qualitative design. Individual in-depth interviews with all members of the executive management team at an emergency hospital in Norway were analysed using reflexive thematic method.

Findings
The top managers had the intention to balance between quality of patient care, economy and professionals’ engagement. This became increasingly difficult in times of high internal or external pressures. Then top management acted as if economy was the most important focus.

Practical implications
For health-care top managers to lead the pursuit towards increased sustainability in health care, there is a need to balance between quality of patient care, economy and professionals’ engagement. This study shows that this balancing act is not an anomaly top-managers can eradicate. Instead, they need to recognize, accept and deliberately act with that in mind, which can create virtuous development spirals where managers and health-professional communicate and collaborate, benefitting quality of patient care, economy and professionals’ engagement. However, this study builds on a limited number of participants. More research is needed.

Originality/value
Sustainable health care needs to balance quality of patient care and economy while at the same time ensure professionals’ engagement. Even though this is a central leadership task for managers at all levels, there is limited knowledge about how top managers reason about this.
Lived experiences of successful women entrepreneurs (SMEs) in Iran: a feminist phenomenological study
Authors: Sadrnabavi Fatemeh , Daneshvar Hanieh 
Published: December 2022

Purpose
This study aims to investigate the entrepreneurial actions of successful Iranian women entrepreneurs. It is an attempt to find the roots, motivations, challenges and strategies of successful actions of these women, despite the unequal and masculine structure of the society.

Design/methodology/approach
This research was conducted through the theoretical framework of poststructuralist feminism and the qualitative method. By purposive sampling, the researchers selected 10 women entrepreneurs living in Khorasan Razavi province for in-depth interviews. These women have created many jobs based on local potential and become recognized as top entrepreneurs. The narratives of these women were analyzed phenomenologically.

Findings
The actions of these women are fertilized under the influence of family background and early socialization and in the combination of internal motivations and external stimuli. These women resist social barriers such as widespread patriarchy, gender division of labor in society and complex bureaucratic processes through the “strategic cycle” resulting from the interaction of “reliance on intertwined social networks,” “social entrepreneurship,” “gradual formation of social capital” and “reliance on local potentials.”

Social implications
The strategies to overcome gender inequalities at the micro (family) and macro (society) levels introduced in this research can inspire women entrepreneurs who seek success in their businesses.

Originality/value
To the best of the authors’ knowledge, this is the first qualitative research that, by studying the actions of successful Iranian women entrepreneurs, describes how they overcome structural inequalities and their success strategies.