bluuebunny/crossref_metadata_2025_split huggingface dataset:
Telomere and mitochondria mediated the association between dietary inflammatory index and mild cognitive impairment: A prospective cohort study
Authors: Liu Qian , Li Zhenshu , Huang Ling , Zhou Dezheng , Fu Jingzhu , Duan Huilian , Wang Zehao , Yang Tong , Zhao Jing , Li Wen , Liu Huan , Ma Fei , Sun Changqing , Wang Guangshun , Du Yue , Zhang Meilin , Chen Yongjie , Huang Guowei 
Published: January 2023

Abstract
Background
Diet and chronic inflammation might play a major role in the pathogenesis of mild cognitive impairment (MCI). In addition, peripheral blood leukocyte telomere length (LTL) and mitochondrial DNA copy number (mtDNAcn) might mediate the relationship between inflammation and MCI risk. The purpose of the present study is to evaluate whether inflammatory potential of diet assessed by dietary inflammatory index (DII), chronic inflammation, peripheral blood LTL, and mtDNAcn were associated with the risk of MCI.

Results
A population-based cohort study was conducted with a total of 2944 participants. During a median follow-up of 2 years, 438 (14.90%) individuals were new-onset MCI. After adjustment, a higher score of DII (hazard ratio [HR]: 1.056, 95% CI: 1.005, 1.109), a higher log systemic immune inflammation index (SII) (HR: 1.333, 95% CI: 1.089, 1.633) and log system inflammation response index (SIRI) (HR: 1.487, 95% CI: 1.024, 2.161) predicted elevated risk of MCI. An increased mtDNAcn (HR: 0.843, 95% CI: 0.712, 0.997), but not LTL, predicted a decreased risk of MCI. Negative associations of log SII with LTL (β:-0.359, 95% CI: -0.445, -0.273) and mtDNAcn (β:-0.048, 95% CI: -0.090, -0.006) were found. Additionally, negative associations of log SIRI with LTL (β: -0.035, 95% CI: -0.052, -0.017) and mtDNAcn (β:-0.136, 95% CI: -0.216, -0.056) were also found. Path analysis suggested that SIRI, LTL, and mtDNAcn, in series, have mediation roles in the association between DII score and MCI risk.

Conclusions
Higher DII, SII, and SIRI might predict a greater risk of MCI, while a longer LTL and an increased mtDNAcn were linked to a reduced risk of MCI among the older population. LTL and mtDNAcn could play mediation roles in the association between DII and MCI risk.
Putative adverse outcome pathways for silver nanoparticle toxicity on mammalian male reproductive system: a literature review
Authors: Kose Ozge , Mantecca Paride , Costa Anna , Carrière Marie 
Published: January 2023

Abstract
Background
Adverse outcome pathways (AOPs) are conceptual frameworks that organize knowledge about biological interactions and toxicity mechanisms. They present a sequence of events commencing with initial interaction(s) of a stressor, which defines the perturbation in a biological system (molecular initiating event, MIE), and a dependent series of key events (KEs), ending with an adverse outcome (AO). AOPs have recently become the subject of intense studies in a view to better understand the mechanisms of nanomaterial (NM) toxicity. Silver nanoparticles (Ag NPs) are one of the most explored nanostructures and are extensively used in various application. This, in turn, has increased the potential for interactions of Ag NPs with environments, and toxicity to human health. The aim of this study was to construct a putative AOPs (pAOP) related to reproductive toxicity of Ag NPs, in order to lay the groundwork for a better comprehension of mechanisms affecting both undesired toxicity (against human cell) and expected toxicity (against microorganisms).

Methods
PubMed and Scopus were systematically searched for peer-reviewed studies examining reproductive toxicity potential of Ag NPs. The quality of selected studies was assessed through ToxRTool. Eventually, forty-eight studies published between 2005 and 2022 were selected to identify the mechanisms of Ag NPs impact on reproductive function in human male. The biological endpoints, measurements, and results were extracted from these studies. Where possible, endpoints were assigned to a potential KE and an AO using expert judgment. Then, KEs were classified at each major level of biological organization.

Results
We identified the impairment of intracellular SH-containing biomolecules, which are major cellular antioxidants, as a putative MIE, with subsequent KEs defined as ROS accumulation, mitochondrial damage, DNA damage and lipid peroxidation, apoptosis, reduced production of reproductive hormones and reduced quality of sperm. These successive KEs may result in impaired male fertility (AO).

Conclusion
This research recapitulates and schematically represents complex literature data gathered from different biological levels and propose a pAOP related to the reproductive toxicity induced by AgNPs. The development of AOPs specific to NMs should be encouraged in order to provide new insights to gain a better understanding of NP toxicity.
Spatial and Texture Analysis of Root System distribution with Earth mover’s Distance (STARSEED)
Authors: Peeples Joshua , Xu Weihuang , Gloaguen Romain , Rowland Diane , Zare Alina , Brym Zachary 
Published: January 2023

AbstractPurposeRoot system architectures are complex and challenging to characterize effectively for agronomic and ecological discovery.MethodsWe propose a new method, Spatial and Texture Analysis of Root SystEm distribution with Earth mover’s Distance (STARSEED), for comparing root system distributions that incorporates spatial information through a novel application of the Earth Mover’s Distance (EMD).ResultsWe illustrate that the approach captures the response of sesame root systems for different genotypes and soil moisture levels. STARSEED provides quantitative and visual insights into changes that occur in root architectures across experimental treatments.ConclusionSTARSEED can be generalized to other plants and provides insight into root system architecture development and response to varying growth conditions not captured by existing root architecture metrics and models. The code and data for our experiments are publicly available:https://github.com/GatorSense/STARSEED.
Comparing external fixators and intramedullary nailing for treating open tibia fractures: a meta-analysis of randomized controlled trials
Authors: Liu Jun , Xie Lifeng , Liu Li , Gao Guicheng , Zhou Ping , Chu Dejun , Qiu Dewei , Tao Jun 
Published: January 2023

Abstract
Background
External fixators (EFs) and intramedullary nailing (IMN) are two effective methods for open tibial fractures. However, both methods have advantages and disadvantages, and the optimal surgical approach remains controversial. Thus, we performed a meta-analysis of randomized controlled trials (RCTs) to compare EF with IMN to evaluate their efficacy and safety.

Methods
A systematic study of the literature was conducted in relevant studies published in PubMed, Embase, the Cochrane Library, Web of Science, CNKI, CBM, Wanfang and Weipu from database inception to April 2022. All eligible literature was critically appraised for methodological quality via the Cochrane's collaboration tool. The primary outcome measurements included postoperative superficial infection, postoperative deep infection, union time, delayed union, malunion, nonunion, and hardware failure.

Results
Nine RCTs involving 733 cases were included in the current meta-analysis. The pooled results suggested that cases in the IMN group had a significantly lower postoperative superficial infection rate [risk ratio (RR) = 2.84; 95% confidence interval (CI) = 1.83 to 4.39; P < 0.00001)] and malunion rate (RR = 3.05; 95% CI = 2.06 to 4.52; P < 0.00001) versus EF, but IMN had a significantly higher hardware failure occurrence versus EF (RR = 0.38; 95% CI = 0.17 to 0.83; P = 0.02). There were no significant differences in the postoperative deep infection rate, union time, delayed union rate or nonunion rate between the two groups (p > 0.05).

Conclusions
Compared to EF, IMN had a significantly lower risk of postoperative superficial infection and malunion in patients with open tibial fractures. Meanwhile, IMN did not prolong the union time and increased the risk of the deep infection rate, delayed union rate and nonunion rate but had a higher hardware failure rate. The reanalysis of union time showed that it was significantly shorter in the IMN group than in the EF group after excluding the study with significant heterogeneity during sensitivity analysis. Therefore, IMN is recommended as a preferred method of fracture fixation for patients with open tibial fractures, but more attention should be given to the problem of hardware failure.
Efficacy and safety of tranexamic acid in posterior lumbar interbody fusion: a meta-analysis of randomized controlled trials
Authors: Luan Haopeng , Liu Kai , Peng Cong , Tian Qi , Song Xinghua 
Published: January 2023

Abstract
Objective
To evaluate the efficacy and safety of tranexamic acid (TXA) in hemostasis in patients undergoing posterior lumbar interbody fusion (PLIF) by meta-analysis.

Methods
This study was registered on the International Prospective Register of Systematic Reviews (PROSPERO) (ID: CRD42022354812). The databases PubMed, Cochrane Library, Web of Science, and Embase were searched for randomized controlled trial (RCT) papers on the use of TXA in patients with PLIF from database establishment to August 2022. Two researchers screened the literature, extracted data, evaluated the risk of bias of the included studies, recorded the authors, sample size, type of study design, and TXA dose of each study, and extracted the intraoperative blood loss, number of blood transfusions, total blood loss, drainage volume, operation time, and incidence of deep venous thrombosis in each study. Meta-analysis was performed using RevMan 5.4 software provided by Cochrane Library.

Results
A total of 14 RCTs with a total of 1681 patients were included in this study, including 836 patients in the TXA group and 845 patients in the control group. The intraoperative blood loss [mean difference (MD) = − 125.97, 95% confidence interval (CI) (− 138.56, − 113.37), P < 0.0001] and less total blood loss [MD = − 204.28, 95% CI (− 227.38, − 181.18), P < 0.00001] in TXA group were lower than the control group. Statistical significance was also observed in postoperative drainage volume [MD = − 115.03, 95% CI (− 123.89, − 106.17), P < 0.00001], operation time [MD = − 8.10, 95% CI (− 14.49, − 1.71), P = 0.01], and blood transfusion rate [odds ratio (OR) = 0.30, 95% CI (0.23, 0.39), P < 0.00001]. However, there was no statistical difference observed in the incidence of deep venous thrombosis [OR = 0.83, 95% CI (0.56, 1.21), P = 0.33].

Conclusion
The application of TXA in PLIF can reduce intraoperative blood loss, total blood loss, drainage volume, the incidence of transfusion events, and operation time without increasing the risk of deep venous thrombosis.
SIGIRR-caspase-8 signaling mediates endothelial apoptosis in Kawasaki disease
Authors: Wen Zhengwang , Xia Yuhan , Zhang Yingying , He Yuxi , Niu Chao , Wu Rongzhou , Zhang Chunxiang , Jia Chang , Rong Xing , Chu Maoping 
Published: January 2023

Abstract
Background
Kawasaki disease (KD) is a kind of vasculitis with unidentified etiology. Given that the current diagnosis and therapeutic strategy of KD are mainly dependent on clinical experiences, further research to explore its pathological mechanisms is warranted.

Methods
Enzyme linked immunosorbent assay (ELISA) was used to measure the serum levels of SIGIRR, TLR4 and caspase-8. Western blotting was applied to determine protein levels, and flow cytometry was utilized to analyze cell apoptosis. Hematoxylin eosin (HE) staining and TUNEL staining were respectively used to observe coronary artery inflammation and DNA fragmentation.

Results
In this study, we found the level of SIGIRR was downregulated in KD serum and KD serum-treated endothelial cells. However, the level of caspase-8 was increased in serum from KD patients compared with healthy control (HC). Therefore, we hypothesized that SIGIRR-caspase-8 signaling may play an essential role in KD pathophysiology. In vitro experiments demonstrated that endothelial cell apoptosis in the setting of KD was associated with caspase-8 activation, and SIGIRR overexpression alleviated endothelial cell apoptosis via inhibiting caspase-8 activation. These findings were also recapitulated in the Candida albicans cell wall extracts (CAWS)-induced KD mouse model.

Conclusion
Our data suggest that endothelial cell apoptosis mediated by SIGIRR-caspase-8 signaling plays a crucial role in coronary endothelial damage, providing potential targets to treat KD.
Levels and correlates of risk factor control in diabetes mellitus –ELSA-Brasil
Authors: Chwal Bruna Cristine , dos Reis Rodrigo Citton Padilha , Schmidt Maria Inês , Duncan Bruce B. , Barreto Sandhi Maria , Griep Rosane Harter 
Published: January 2023

Abstract
Background
Control of glucose, blood pressure, cholesterol, and smoking improves the prognosis of individuals with diabetes mellitus. Our objective was to assess the level of control of these risk factors in Brazilian adults with known diabetes and evaluate correlates of target achievement.

Methods
Cross-sectional sample of the Brazilian Longitudinal Study of Adult Health, composed of participants reporting a previous diagnosis of diabetes or the use oof antidiabetic medication. We measured glycated hemoglobin (HbA1c) and LDL-cholesterol at a central laboratory and blood pressure following standardized protocols. We defined HbA1c  < 7% as glucose control (target A); blood pressure  < 140/90 mmHg (or  < 130/80 mmHg in high cardiovascular risk) as blood pressure control (target B), and LDL-c  < 100 mg/dl (or  < 70 mg/dl in high risk) as lipid control (target C), according to the 2022 American Diabetes Association guidelines.

Results
Among 2062 individuals with diabetes, 1364 (66.1%) reached target A, 1596 (77.4%) target B, and 1086 (52.7%) target C; only 590 (28.6%) achieved all three targets. When also considering a non-smoking target, those achieving all targets dropped to 555 (26.9%). Women (PR = 1.13; 95%CI 1.07–1.20), those aged  ≥ 74 (PR = 1.20; 95%CI 1.08–1.34), and those with greater per capita income (e.g., greatest income PR = 1.26; 95%CI 1.10–1.45) were more likely to reach glucose control. Those black (PR = 0.91; 95%CI 0.83–1.00) or with a longer duration of diabetes (e.g., ≥ 10 years PR = 0.43; 95%CI 0.39–0.47) were less likely. Women (PR = 1.05; 95%CI 1.00–1.11) and those with private health insurance (PR = 1.15; 95%CI 1.07–1.23) were more likely to achieve two or more ABC targets; and those black (PR = 0.86; 95%CI 0.79–0.94) and with a longer duration of diabetes (e.g., > 10 years since diabetes diagnosis, PR = 0.68; 95%CI 0.63–0.73) less likely.

Conclusion
Control of ABC targets was poor, notably for LDL-c and especially when considering combined control. Indicators of a disadvantaged social situation were associated with less frequent control.
Quantitative versions of the two-dimensional Gaussian product inequalities
Authors: Hu Ze-Chun , Zhao Han , Zhou Qian-Qian 
Published: January 2023

AbstractThe Gaussian product-inequality (GPI) conjecture is one of the most famous inequalities associated with Gaussian distributions and has attracted much attention. In this note, we investigate the quantitative versions of the two-dimensional Gaussian product inequalities. For any centered, nondegenerate, and two-dimensional Gaussian random vector$(X_{1}, X_{2})$(X1,X2)with$E[X_{1}^{2}]=E[X_{2}^{2}]=1$E[X12]=E[X22]=1and the correlation coefficientρ, we prove that for any real numbers$\alpha _{1}, \alpha _{2}\in (-1,0)$α1,α2∈(−1,0)or$\alpha _{1}, \alpha _{2}\in (0,\infty )$α1,α2∈(0,∞), it holds that$$ {\mathbf{E}}\bigl[ \vert X_{1} \vert ^{\alpha _{1}} \vert X_{2} \vert ^{\alpha _{2}}\bigr]-{\mathbf{E}}\bigl[ \vert X_{1} \vert ^{ \alpha _{1}}\bigr]{\mathbf{E}}\bigl[ \vert X_{2} \vert ^{\alpha _{2}}\bigr]\ge f(\alpha _{1}, \alpha _{2}, \rho )\ge 0, $$E[|X1|α1|X2|α2]−E[|X1|α1]E[|X2|α2]≥f(α1,α2,ρ)≥0,where the function$f(\alpha _{1}, \alpha _{2}, \rho )$f(α1,α2,ρ)will be given explicitly by the Gamma function and is positive when$\rho \neq 0$ρ≠0. When$-1<\alpha _{1}<0$−1<α1<0and$\alpha _{2}>0$α2>0, Russell and Sun (Statist. Probab. Lett. 191:109656, 2022) proved the “opposite Gaussian product inequality”, of which we will also give a quantitative version. These quantitative inequalities are derived by employing the hypergeometric functions and the generalized hypergeometric functions.
Effect of regulatory cell death on the occurrence and development of head and neck squamous cell carcinoma
Authors: Xue Yuting , Jiang Xuejiao , Wang Junrong , Zong Yuxuan , Yuan Zhennan , Miao Susheng , Mao Xionghui 
Published: January 2023

AbstractHead and neck cancer is a malignant tumour with a high mortality rate characterized by late diagnosis, high recurrence and metastasis rates, and poor prognosis. Head and neck squamous cell carcinoma (HNSCC) is the most common type of head and neck cancer. Various factors are involved in the occurrence and development of HNSCC, including external inflammatory stimuli and oncogenic viral infections. In recent years, studies on the regulation of cell death have provided new insights into the biology and therapeutic response of HNSCC, such as apoptosis, necroptosis, pyroptosis, autophagy, ferroptosis, and recently the newly discovered cuproptosis. We explored how various cell deaths act as a unique defence mechanism against cancer emergence and how they can be exploited to inhibit tumorigenesis and progression, thus introducing regulatory cell death (RCD) as a novel strategy for tumour therapy. In contrast to accidental cell death, RCD is controlled by specific signal transduction pathways, including TP53 signalling, KRAS signalling, NOTCH signalling, hypoxia signalling, and metabolic reprogramming. In this review, we describe the molecular mechanisms of nonapoptotic RCD and its relationship to HNSCC and discuss the crosstalk between relevant signalling pathways in HNSCC cells. We also highlight novel approaches to tumour elimination through RCD.
Brazilian Portuguese version and content validity of the Strengthening and Stretching for Rheumatoid Arthritis of the Hand (SARAH)
Authors: Castro Rayane Quintão , Barros Lívia Vilela , de Carvalho Pedro Henrique Berbert , Fonseca Diogo Simões , Miyamoto Samira Tatiyama , Coelho Cristina Martins , Machado Germano Luís Rocha , Forechi Ludimila 
Published: January 2023

Abstract
Introduction
The Strengthening and Stretching for Rheumatoid Arthritis of the Hand (SARAH) program is a personalized, progressive 12-week exercise program for people with hand problems due to rheumatoid arthritis (RA). Patients are provided with two guidance documents, the ‘Patient Exercise Booklet’ and the ‘Personal Exercise Guide’, to continue the exercises independently at home.

Objective
This study aimed to translate and culturally adapt the SARAH protocol into Brazilian Portuguese and validate its content.

Methods
The guidance documents ‘Patient Exercise Booklet’ and ‘Personal Exercise Guide’ of the SARAH program were translated and culturally adapted to Brazilian Portuguese. The content validity was obtained by calculating the content validity index (CVI).

Results
The Brazilian version of the SARAH protocol reached semantic, idiomatic, conceptual, and cultural equivalences. The CVI was greater than 0.8, corresponding to a satisfactory index. The verbal comprehension was 4.9, showing good verbal comprehension of the target population.

Conclusion
The Brazilian Portuguese version of the SARAH protocol is available to Brazilian people with compromised hands due to RA with satisfactory content validity.
Optimum generation scheduling incorporating wind energy using HHO–IGWO algorithm
Authors: Dhawale Dinesh , Kamboj Vikram Kumar , Anand Priyanka 
Published: January 2023

AbstractRecently, renewable energy participation is gaining importance in the existing power system. However, the large penetration of these renewable energy sources into the existing power system network may cause an imbalance in supply and demand response. Unit commitment is the decision-making process in which generating units are turned ON and OFF at the hourly interval as per the load demand under certain constraints to provide economic scheduling. Thus, an advanced intelligent approach is needed to cope with this combined unit commitment problem with a large penetration of intermittent sources. This paper offers the solution to optimal scheduling by implementing the hybrid Harris Hawks optimizer algorithm (HHO–IGWO). Standard IEEE systems with 10-, 19-, 20-, and 40 units are simulated. Further, to test the feasibility and effectiveness of the proposed method, a comparative analysis for a 10-, 20-, and 40-unit system has also been performed with penetration. The comparative analysis reveals that proposed is more efficient in tackling unit commitment problem in the presence of wind as renewable energy source.
Enhancing image resolution of confocal fluorescence microscopy with deep learning
Authors: Huang Boyi , Li Jia , Yao Bowen , Yang Zhigang , Lam Edmund Y. , Zhang Jia , Yan Wei , Qu Junle 
Published: January 2023

AbstractSuper-resolution optical imaging is crucial to the study of cellular processes. Current super-resolution fluorescence microscopy is restricted by the need of special fluorophores or sophisticated optical systems, or long acquisition and computational times. In this work, we present a deep-learning-based super-resolution technique of confocal microscopy. We devise a two-channel attention network (TCAN), which takes advantage of both spatial representations and frequency contents to learn a more precise mapping from low-resolution images to high-resolution ones. This scheme is robust against changes in the pixel size and the imaging setup, enabling the optimal model to generalize to different fluorescence microscopy modalities unseen in the training set. Our algorithm is validated on diverse biological structures and dual-color confocal images of actin-microtubules, improving the resolution from ~ 230 nm to ~ 110 nm. Last but not least, we demonstrate live-cell super-resolution imaging by revealing the detailed structures and dynamic instability of microtubules.
Phase analysis of signals using frequency-dependent attenuation for measurements of seismic waves
Authors: Zeng Hu , Yeh Hen-Geul , Zou Guan-Gui , Gong Fei , Peng Su-Ping , She Jia-Sheng , Zhao Tai-Lang 
Published: January 2023

Attenuation refers to any decrease in the power of a propagated signal through a medium. Attenuation measurement techniques include ultrasonic, resonance bar, and stress-strain methods. The stress-strain method measures elastic and viscoelastic properties in the seismic frequency range. The signals received via attenuation measurement systems using the stress-strain method can be considerably weak. Moreover, the noise in these signals causes errors when estimating the signal phase-angle difference between the sample signal and probe signal, thereby reducing system precision and measurement accuracy. Accurate measurements of such phase differences are essential to the measurement of attenuation. A seismic-wave attenuation with frequency-dependent measurement based on the stress-strain method and digital signal processing techniques has been performed. The system estimates the attenuation of a rock by measuring the phase shift in the stress-strain cycle. As a preprocessing method, the finite impulse response band-pass filters are designed to eliminate the influence of noise and direct current offset while ensuring that the phase difference of the measured signal remains unchanged. Three methods for phase difference estimation, i.e., crosscorrelation, fast Fourier transform (FFT), and Hilbert transform are compared, for different signal-to-noise ratios, sampling frequencies, data sample lengths, and true phase differences. The results find that the phase difference estimation based on FFT is the best among all three methods and can effectively improve the precision of the experimental results. Simulation and measurement results further indicate that the attenuation measurement system achieves stable and reliable attenuation measurements in the range of 3–2000 Hz.