bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quantum Lenoir engine in the presence of minimal length
Authors: Sukamto Heru , Yuwana Lila , Purwanto Agus 
Published: January 2023

Abstract
The effect of minimal length for quantum heat engine systems is proposed. We use a system of trapped Fermi particles in an infinite potential well. The thermodynamic cycle chosen is the reversible Lenoir cycle. We use both a single particle case and a multiparticle case. The result is that the minimum length increases the efficiency of the engine if the width of the potential well is infinitely small, and the maximum value is obtained when the width of the potential well is close to zero.
A coupled fractional-order system with fluctuating frequency and its application in bearing fault diagnosis
Authors: He Lifang , Liu Xiaoman , Jiang Zhongjun 
Published: January 2023

Abstract
In this paper, a coupled fractional-order system with fluctuating frequency driven by different periodic signals under various damping strength is investigated. Firstly, based on the Shapiro-Loginov formula and Laplace transform method, the expressions for the output amplitude gain (OAG) of the two subsystems are derived and the resonant behaviors of particles are analyzed. The OAG exhibits various resonance behaviors in response to variations in system parameters, input signals and dichotomous noise, including parameter-induced stochastic resonance, bona-fide resonance and stochastic resonance. Especially, the average behavior of the two output signals is synchronized when two subsystems’ input signals and damping strengths are equal, which is verified in the numerical simulation. Finally, the proposed system is applied to the bearing fault diagnosis to evaluate its engineering application value. The results prove that the system is effective in diagnosing fault signals and has excellent performance.
3D silicon detectors for neutron imaging applications
Authors: Povoli M. , Kok A. , Koybasi O. , Getz M. , O’Neill G. , Roehrich D. , Monakhov E. , Pedersen H. , Birch J. , Choolakkal A.H. , Kanaki K. , Lai C.-C. , Hall-Wilton R. , Slavicek T. , Llamas Jansa I. 
Published: January 2023

Abstract
Neutron detection is of great importance in many fields spanning from scientific research, to nuclear science, and to medical application. The development of silicon-based neutron detectors with enhanced neutron detection efficiency can offer several advantages such as spatial resolution, enhanced dynamic range and background discrimination. In this work, increased detection efficiency is pursued by fabricating high aspect ratio 3D micro-structures filled with neutron converting materials (B4C) on planar silicon detectors. An in-depth feasibility study was carried out in all aspects of the sensor fabrication technology. Passivation of the etched structures was studied in detail, to ensure good electrical performance. The conformal deposition of B4C with a newly developed process showed excellent results. Preliminary electrical characterisation of the completed devices is promising, and detectors have been mounted on dedicated boards in view of the upcoming tests with neutrons.
Strengthening Farmer Organization for Smallholder Farmers
Authors: Mustikaningrum Dhina 
Published: January 2023

Abstract
One of Smallholder farmers face various obstacles in developing their farming business including access to capital one of the efforts to answer the challenge is to strengthen farmer organizations. In Tuban, there is a HIPPA or Water User Farmers Association that is able to provide capital for farmers and contribute to Village Income. This study aims to analyze strategies to strengthen HIPPA Sekar Padi in Bandungrejo Village to increase capital loans for farmer and village income. The method used in this study is SWOT analysis based on the results of processing organizational documents and in-depth interviews with HIPPA administrators and farmers. The main strategy to strengthen HIPPA to contribute to village income and provide capital for farmers is reduce fuel and electricity consumption and ensure that the Tuban Regency Government accelerates the construction of flood prevention infrastructure. Through changing the electricity tariff class from business to industry, HIPPA can contribute 35-45 million rupiah to village income in dry season and more than 100 million rupiah to increase capital for famers. In the rainy season, HIPPA relies heavily on government policies to control floods. By increasing capital for farmers, it is hoped that it can help farmer access production facilities. By additional village income, the village government can build basic infrastructure and increasing social funds, so that the welfare of the smallholder farmers as part of SDG’s indicator can be improved.
Growth and fruit yield of sponge gourd (Luffa acutangulaL.) as influenced by combination of plant spacing and chicken manure
Authors: Fahreza A R , Aini N 
Published: January 2023

Abstract
This study aims to determine the growth and yield of sponge gourd (Luffa acutangula L.) by adjusting the spacing and doses of chicken manure. A field experiment was conducted at experimental station of Brawijaya University, Malang Regency, East Java. This study used a Randomized Block Design (RBD) with one combination factor. The treatment combination is plant spacing + chicken manure doses, which consist of: P0 = 60 x 50 cm + 4 t ha−1, P1 = 40 x 50 cm + 4 t ha−1, P2 = 60 x 50 cm + 6 t ha−1, P3 = 40 x 50 cm + 6 t ha−1, P4 = 60 x 50 cm + 8 t ha−1, P5 = 40 x 50 cm + 8 t ha−1. Obsevation variables are number of Leaves, plant length, leaf area, fruit weight per fruit and fruit weight per plant, number of fruits, and yield of fruit. The results showed that the treatment with a spacing of 40 × 50 cm + 8 t ha−1 chicken manure significant increasing the growth and fruit yield of sponge gourd. However, the fruit weight per plant with a spacing of 60 × 50 cm + 8 t ha−1 chicken manure had a higher value than the treatment with a spacing of 40 × 50 cm + 8 t ha−1 chicken manure. R/C ratio of all treatments are more than one. The treatment with a spacing of 40 × 50 cm + 8 t ha−1 chicken manure is not only feasible to cultivate, but can also be used for sustainable agriculture.
Study of antibiosis of Streptomyces sp. from the land of shallot plants as biological agents of Fusariumsp. cause of Twisted diseases (Moler)
Authors: Suryaminarsih Penta , Mujoko Tri , Gusriyan K , Wijayanti Fitri , Mohammad Salmah 
Published: January 2023

Abstract
The use of bio pesticides and organic pesticides from secondary metabolic filtrate of APH microorganisms is one of the food and horticulture cultivation technology packages which are the basis for this research objective. The research objective was to explore, isolate and identify of Streptomyces sp. in the land of shallot plants (Abm) and the antibiosis against the pathogens Fusariumsp cause of Moler shallot plant in vitro. Observer of Quality and quantity characteristics of secondary metabolites as antibiosis, The results showed that Streptomyces sp from land of shallot plant (Abm) isolates producing little antibiosis less able to inhibit the development of the pathogens Fusariumsp cause of Moler shallot plant in vitro. The identification of Actinomycetes spp. based on the morphology characteristic showed that Actinomycetes isolates are closely related with Streptomyces sp.
Efficient matter-wave lensing of ultracold atomic mixtures
Authors: Meister Matthias , Roura Albert 
Published: January 2023

Abstract
Mixtures of ultracold quantum gases are at the heart of high-precision quantum tests of the weak equivalence principle, where extremely low expansion rates have to be reached with matter-wave lensing techniques. We propose to simplify this challenging atom-source preparation by employing magic laser wavelengths for the optical lensing potentials, which guarantee that all atomic species follow identical trajectories and experience common expansion dynamics. In this way, the relative shape of the mixture is conserved during the entire evolution while cutting in half the number of required lensing pulses compared to standard approaches.
Exploring the limits of ultracold atoms in space
Authors: Thompson R J , Aveline D C , Chiow Sheng-Wey , Elliott E R , Kellogg J R , Kohel J M , Sbroscia M S , Schneider C , Williams J R , Lundblad N , Sackett C A , Stamper-Kurn D , Woerner L 
Published: January 2023

Abstract
Existing space-based cold atom experiments have demonstrated the utility of microgravity for improvements in observation times and for minimizing the expansion energy and rate of a freely evolving coherent matter wave. In this paper we explore the potential for space-based experiments to extend the limits of ultracold atoms utilizing not just microgravity, but also other aspects of the space environment such as exceptionally good vacuums and extremely cold temperatures. The tantalizing possibility that such experiments may one day be able to probe physics of quantum objects with masses approaching the Planck mass is discussed.
Temperature-assisted microstructure development for TiB2 reinforced Cu matrix composite
Authors: Murmu Uttam Kumar , Ghosh Abhishek , Ghosh Manojit 
Published: January 2023

Abstract
The current research demonstrates the fabrication and characterization of TiB2-reinforced (10%) Cu matrix composite through a powder metallurgy route. The composites have been prepared by hot compaction (200 °C and 500 °C) of Cu and TiB2 powders subsequent to mechanical milling in a high-energy planetary mill. The influence of temperature on the microstructure, hardness, and mechanical properties of the composites was investigated. The development of clean and well-connected interfaces between matrix and reinforcement is revealed by scanning electron microscopy (SEM). X-ray diffraction (XRD) revealed the absence of intermetallic compounds during the entire tenure of the ball milling and consolidation process. Differential scanning calorimetry (DSC) analysis displayed the possibility of oxide formation with the gases trapped inside the pores of the compacts that could not be ignored. The kinetics of the formation of Cu2O phases with associated activation energies at various temperatures were calculated using Johnson-Mehl-Avramani (JMA) equation. The values of activation energy (Q) were 405.14, 573.74, and 705.69 (KJ mol−1) for sintering at 500 °C, 200 °C, and RT, respectively. This indicates the formation of endothermic peaks at a lower temperature for samples with higher consolidation temperatures. A uniform distribution of hardness on the cross-section ensured proper load spread and an accurate selection of the H (height)/D (diameter) ratio during compaction. Increasing hardness with higher consolidation temperature might sound aberrated from the traditional understanding of softening with temperature through grain growth. A hardness value of 158.5 Hv at a higher consolidation temperature (500 °C) achieved through a reduction of porosity by removing entrapped gases with temperature outweighs the softening effect.
The stochastic nature of power-grid frequency in South Africa
Authors: Rydin Gorjão Leonardo , Maritz Jacques 
Published: January 2023

Abstract
In this work, we explore two mechanisms that explain non-Gaussian behaviour of power-grid frequency recordings in the South African grid. We make use of a Fokker–Planck approach to power-grid frequency that yields a direct relation between common model parameters such as inertia, damping, and noise amplitude and non-parametric estimations of the same directly from power-grid frequency recordings. We propose two explanations for the non-Gaussian leptokurtic distributions in South Africa: the first based on multiplicative noise in power-grid frequency recordings, which we observe in South Africa; the second based on the well-known scheduled and unscheduled load shedding and rolling blackouts that beset South Africa. For the first we derive an analytic expression of the effects of multiplicative noise that permits the estimation of all statistical moments—and discuss drawbacks in comparison with the data; for the second we employ a simple numerical analysis with a modular power grid of South Africa. Both options help understand the statistics of power-grid frequency in South Africa—particularly the presence of heavy tails.
Plasmid-free CRISPR/Cas9 genome editing inSaccharomyces cerevisiae
Authors: Nishimura Akira , Tanahashi Ryoya , Oi Tomoki , Kan Kyoyuki , Takagi Hiroshi 
Published: January 2023

ABSTRACTThe current CRISPR/Cas9 systems in the yeast Saccharomyces cerevisiae cannot be considered a non-genetic modification technology because it requires the introduction of Cas9 and sgRNA into yeast cells using plasmid expression systems. Our present study showed that the yeast genome can be edited without plasmid expression systems by using a commercially available protein transfection reagent and chemically modified sgRNAs.
Confirm Not Command: Examining Fraudsters’ Use of Language to Compel Victim Compliance in Their Own Exploitation
Authors: Carter Elisabeth 
Published: January 2023

Abstract
Using discourse analysis to examine exchanges between fraudsters and victims in telephone-mediated frauds, this research examines the interactional techniques used by perpetrators of fraud to gain and maintain compliance from their victims, without causing them alarm. It reveals how compliance is secured and maintained in a process of establishing the relationship, grooming the victim and setting expectations of follow-through. Reimagining traditional understandings of fraud victimization and vulnerability, this work exposes how social and interactional norms are replicated and manipulated by fraudsters in order to compel individuals to be drawn into participating in an alternate, exploitative reality that is indistinguishable from safety; quashing a victim’s ability to recognize the situation as harmful and rendering any motivation to escape as nonsensical. In doing so, this paper questions the efficacy of public fraud protection guidance strategies and delivers evidence for the need to change the present approach to understanding and tackling fraud victimization and complicity.
314 Injection site reactions from an integrated analysis of phase 2 and phase 3 clinical trials of lebrikizumab treatment in moderate-to-severe atopic dermatitis
Authors: Gooderham Melinda , Shi Vivian Y , Wollenberg Andreas , Thyssen Jacob P , Torres Tiago , Gil Esther Garcia , Bardolet Laia , Natalie Chitra R , Atwater Amber R , Zhao Fangyi , Blauvelt Andrew 
Published: January 2023

Abstract
Lebrikizumab is an injectable, IgG4 monoclonal antibody that selectively binds to interleukin-13 with high affinity. Injection-site reactions (ISRs) are localized adverse events in the immediate site of administration of a drug and are common with injectable therapies. This analysis reports ISRs in patients from eight lebrikizumab (LEB) clinical trials in atopic dermatitis. To report ISRs in patients with moderate-to-severe atopic dermatitis treated with LEB, from an integrated safety analysis of phase 2 and 3 LEB clinical trials. These data sets include adolescents and adult patients who received at least one dose of LEB from a total of eight atopic dermatitis clinical trials, including four 16-week placebo-controlled clinical trials. Eight trials consist of: ADvocate1, ADvocate2, ADhere, ADore, ADjoin (ongoing), ARBAN, TREBLE and Phase 2b study. Treatment duration ranged from a single dose to 100 weeks. ISRs were defined using the preferred terms from the Medical Dictionary for Regulatory Activities high-level term, injection site reactions, excluding terms related to joints. This analysis includes ISRs frequencies in patients treated with LEB compared to placebo (ALL PC week 0–16), and all patients who received any dose of LEB (ALL LEB), and reports ISRs type, exposure adjusted incidence rates (EAIR) per 100 patient-years, the timing of ISRs occurrence, and ISRs leading to discontinuation. In the ALL PC week 0–16 analysis, 2.6% (n = 20/783, EAIR 9.0) of patients in the LEB group reported ISRs vs. 1.5% (n = 6/404 EAIR 5.4) in the placebo group. Injection site pain (n = 7, 0.9%) and injection site erythema (n = 7, 0.9%) were the most frequent reactions reported in the LEB group. Most ISRs were mild or moderate, with only 1 (0.1%) severe event. In the ALL LEB analysis, 3.1% of patients reported ISRs (n = 53/1720, EAIR 3.3). Injection site pain (n = 16, 0.9%) and injection site erythema (n = 12, 0.7%) were the most frequent reactions. Almost all reports were mild or moderate, with 3 (0.2%) severe. The incidence of ISRs did not increase with a longer duration of LEB exposure. The majority of ISRs were reported between weeks 0 and 16 (n = 38, 2.2%). The frequency of ISRs from week 16 to 32 was 1.0% (n = 15), from week 32 to 48 was 0.4% (n = 4) and from week 48 to 64 was 0.2% (n = 2). Treatment discontinuation due to ISRs occurred in a few patients (n = 5, 0.3%). Overall, a low proportion of patients reported ISRs (&lt;3%) with a numerically higher frequency of LEB-treated patients who reported ISRs compared to placebo (1.5%). Most events were mild or moderate in severity, did not lead to treatment discontinuation, occurred within the first 16 weeks of treatment, and ISRs incidence did not increase with a longer duration of exposure.
334 Baseline demographics and family disease history in patients with atopic dermatitis: an update from the GLOBOSTAD registry
Authors: Calzavara-Pinton Piergiacomo , Čelakovská Jarmila , Lapeere Hilde , Holzer Gregor , Al-Ahmad Mona , Chu Chia-Yu , Wu Jiangming , Ardeleanu Marius , Bosman Kwinten 
Published: January 2023

Abstract
The efficacy and safety of dupilumab have been reported previously based on data from controlled clinical trials. The GLOBOSTAD study extends the scope of these trials by providing real-world data. This analysis reports baseline demographics and family disease history in patients with atopic dermatitis (AD) who received treatment with dupilumab in a real-world setting. This 5-year, international, multicentre, non-interventional study (GLOBOSTAD; NCT03992417) included patients ≥12 years old with moderate-to-severe AD (Investigator’s Global Assessment score ≥3) who received dupilumab treatment based on country-specific prescribing criteria. Data reported are for the population at baseline (N = 952; data cut-off: March 2022) in 22 countries. In the 952 patients included at baseline, mean (standard deviation) age at AD onset was 11.1 (16.0) years. Male patients represented 57.8% of patients and White patients 65.2%. The majority of patients were enrolled from Italy (17.2%), Japan (12.4%) and Spain (11.3%). Family history of type 2 inflammatory conditions (number of patients [%]) was prevalent, including AD (364 [38.2%]), asthma (238 [25%]), allergic rhinitis (219 [23%]), food allergies (74 [7.8%]), recurrent or chronic urticaria (31 [3.3%]), nasal polyposis (21 [2.2%]), eosinophilic esophagitis (11 [1.2%]) and other atopic/allergic conditions (39 [4.1%]). Most cases of type 2 inflammatory conditions were reported in first-degree relatives. Most patients enrolled in the GLOBOSTAD study developed AD during pre-adolescence. Family history of select type 2 inflammatory conditions, including AD, asthma and allergic rhinitis, was present in a moderate proportion of patients.
347 The real-world burden of atopic dermatitis: MEASURE-AD multicountry study results from Brazil, Mexico and Argentina
Authors: Jardim Criado Roberta Fachini , Rodrigues Tatiane , de Campos Lucila , Cestari Tania , Maspero Jorge , Luna Paula Carolina , Angles María Valeria , Antila Martti 
Published: January 2023

Abstract
The burden of atopic dermatitis (AD), a chronic, relapsing inflammatory skin disease, increases with disease severity and is associated with multiple flares per year over many years. We characterized the real-world burden of disease, including flares, in patients with AD enrolled in MEASURE-AD from Latin America. Patients (aged ≥12 years) with physician-confirmed AD receiving or eligible for systemic therapy were enrolled in MEASURE-AD between December 2019 and June 2020. Patient characteristics, treatments and outcomes were recorded during a single office visit. Primary outcome measures included worst itch within the past 24 h (Worst Pruritus Numerical Rating Scale [WP-NRS]) and quality of life (QoL; Dermatology Life Quality Index [DLQI] and cDLQI). Among secondary outcomes, the frequency and duration of disease flares within the last 6 months were assessed. Herein result from the Latin American (Brazil, Mexico and Argentina) population (N = 180; adults (≥18 years), n = 157; adolescents, n = 23). Analyses were based on observed data; only descriptive statistics were presented. The mean (SD) age was 33.8 (17.0) years, 52.2% were males and all patients were receiving AD treatment, including 65.6% receiving systemic therapy alone or in combination. Severe pruritus (WP-NRS ≥7) was reported by 54.4% of patients (adults, 57.3%; adolescents, 34.8%). A very or extremely large effect on QoL (DLQI or cDLQI ≥11) was reported among 50.0% of patients ≥16 years and 42.9% of patients 12–15 years. Over the previous 6 months, 0, 1–2, 3–4, 5–6 and &gt;6 flares were reported by 8.3%, 27.2%, 31.1%, 11.7% and 15.6% of patients, respectively. On average, flares lasted 15.2 days (adults, 15.9 days; adolescents, 11.1 days). Although all patients received treatment and two-thirds received systemic therapies, severity scores and impact on QoL and itch were extremely high, suggesting that AD is not adequately controlled in all patients.
Incorrectly Generated RSA Keys: How I Learned To Stop Worrying And Recover Lost Plaintexts
Authors: Shumow Daniel 
Published: January 2023

Abstract
When generating primes $p$ and $q$ for an RSA key, the algorithm specifies that if $p-1$ and $q-1$ must be relatively prime to the public exponent $e$. If this is not done, then the decryption exponent is not well defined. However, what if a software bug allows the generation of public parameters $N$ and $e$ of an RSA key with this property and then it is subsequently used for encryption? Though this may seem like a purely academic question, a software bug in a preview release of the Windows 10 operating system makes this question of more than purely theoretical. Without a well defined decryption exponent, plaintexts encrypted to such keys will be undecryptable thus potentially losing user data, a serious software defect. Though the decryption exponent is no longer well defined, it is in fact possible to recover the a small number of potential plaintexts, if the prime factors $p$ and $q$ of the public modulus $N$ are known. This paper presents an analysis of what steps fail in the RSA algorithm and derives a plaintext recovery algorithm. The runtime of this algorithm is $O(e)$ making it practical to use, and it has been implemented in python.
Transcatheter repair of massive primary mitral regurgitation: beyond the reach of the guidelines
Authors: Eerdekens Rob , Bouwmeester Sjoerd , Zimmermann Frederik M , Brueren Guus R G , Tonino Pim A L 
Published: January 2023

AbstractA 58-year-old male with prior history of mechanical aortic valve replacement (AVR) in 2009 for severe symptomatic aortic regurgitation in a bicuspid aortic valve, and since 2013 a new-onset severe asymptomatic primary mitral regurgitation (MR) due to prolapse of the anterior mitral valve leaflet (AMVL) presented himself with acute heart failure. Based on current guidelines recommendations, this patient was not eligible for transcutaneous mitral valve edge-to-edge repair (TEER), as well he was found as too high risk for conventional mitral valve repair. However, as a last resort TEER was undertaken with an unconventional strategy, which resulted in resolution of the MR and improvement of clinical, biochemical findings.