bluuebunny/crossref_metadata_2025_split huggingface dataset:
Autour du monument Leclerc à Douala
Authors: Nyobe Pascal Ndjock 
Published: January 2025

La construction d’une barrière de protection autour d’une statue coloniale peut-elle participer à sa patrimonialisation ? Question centrale que se pose tout observateur averti au pied du monument dédié au Général Leclerc à Douala et « incarcéré » depuis 2015. Inauguré en 1949, et présenté comme le symbole d’une collaboration réussie entre la France et ses colonies au moment de son édification, le monument va être aussitôt intégré dans l’histoire, la géographie et le paysage de la ville. Les tumultes et la violence qu’a traversés le pays peu avant et au lendemain des indépendances ne remirent pas en cause sa présence, alors même que dans de nombreux pays africains, les indépendances ont donné lieu au renversement tous azimuts des éléments commémoratifs hérités de la colonisation. C’est donc avec quelque surprise que l’on découvre un matin de 2001 les premières traces de contestation de la présence de cette statue dans l’espace public (graffitis, tentatives de déboulonnement). Symbole du rejet de la présence des traces coloniales (monuments, odonymie) dans l’espace public, elle est le théâtre ces dernières années des cérémonies de l’Armistice du 11 novembre 1918 et de la Victoire du 8 mai 1945 organisée par le Consulat général de France. En analysant les documents d’archives, les articles de presses et les enquêtes orales effectuées à Douala, il nous est possible de situer le contexte d’édification de la statue et les enjeux contemporains dont elle est porteuse.
Micronucleus counts correlating with male infertility: a clinical analysis of chromosomal abnormalities and reproductive parameters
Authors: Zhang Shun-Han , Xie Ying-Jun , Qiu Wen-Jun , Pan Qian-Ying , Chen Li-Hao , Wu Jian-Feng , Huang Si-Qi , Wang Ding , Sun Xiao-Fang 
Published: January 2025

Abstract
Investigating the correlation between micronucleus formation and male infertility has the potential to improve clinical diagnosis and deepen our understanding of pathological progression. Our study enrolled 2252 male patients whose semen was analyzed from March 2023 to July 2023. Their clinical data, including semen parameters and age, were also collected. Genetic analysis was used to determine whether the sex chromosome involved in male infertility was abnormal (including the increase, deletion, and translocation of the X and Y chromosomes), and subsequent semen analysis was conducted for clinical grouping purposes. The participants were categorized into five groups: normozoospermia, asthenozoospermia, oligozoospermia, oligoasthenozoospermia, and azoospermia. Patients were randomly selected for further study; 41 patients with normozoospermia were included in the control group and 117 patients with non-normozoospermia were included in the study group according to the proportions of all enrolled patients. Cytokinesis-block micronucleus (CBMN) screening was conducted through peripheral blood. Statistical analysis was used to determine the differences in micronuclei (MNi) among the groups and the relationships between MNi and clinical data. There was a significant increase in MNi in infertile men, including those with azoospermia, compared with normozoospermic patients, but there was no significant difference between the genetic and nongenetic groups in azoospermic men. The presence of MNi was associated with sperm concentration, progressive sperm motility, immotile spermatozoa, malformed spermatozoa, total sperm count, and total sperm motility. This study underscores the potential utility of MNi as a diagnostic tool and highlights the need for further research to elucidate the underlying mechanisms of male infertility.
Effects of glutathione on oocyte and embryo development in in vitro fertilization
Authors: Sonjaya Herry , Damayanti Erni , Iskandar Hikmayani , Baco Sudirman , Hasbi Hasbi , Mujnisa Andi , Prahesti Kusumandari Indah , Khasanah Aulia Uswa Noor , Firmiaty Sri , Nurhidayah Asma’ul Fitriana , Kaiin Ekayanti Mulyawati , Samsudewa Daud , Pala Rukman , Pamungkas Fitra Aji , Herdis Herdis 
Published: January 2025

Objective:
To evaluate the effect of glutathione (GSH) supplementation in maturation and adaptation media on oocyte development, embryo quality, and oocyte viability after vitrification.

Methods:
The GSH concentrations were classified into four groups (0, 0.5, 1.0, and 1.5 mM) which were added to the maturation medium. The maturation process was conducted in vitro for 24 h. Following maturation, oocytes were fertilized with Bali bull semen for 5-6 h and then cultured for 48 h. The morphological quality of ocytes matured with GSH addition and the vitrification method used was evaluated. Parameters assessed included maturation rate, fertilization rate, embryo development, post-vitrification oocyte morphology, and quality of post-vitrification oocytes with GSH added to the adaptation medium.

Results:
The addition of GSH to the maturation medium significantly improved oocyte quality and embryo development (P<0.05). Specifically, adding 1.5 mM GSH increased the percentage of oocytes reaching metaphase II from 57.6% without GSH oocytes to 79.0% with 1.5 mM GSH, two-pronuclei fertilization from 47.0% to 72.7%, embryo development from 37.1% to 57.2%, morula formation from 14.6% to 33.7%, and blastocyst formation from 8.1% to 23.8%. Additionally, the survival rate of oocytes post-vitrification increased to 75% with GSH supplementation.

Conclusions:
The addition of 0.5-1.5 mM of GSH to the maturation and adaptation media significantly enhanced the metaphase II stage, fertilization rates, cleavage rates, and the survival of oocytes after vitrification. Among the concentrations of 1.5 mM was the most effective in increasing oocyte development and maintaining oocytes viability post-vitrification.
Connecting the Dots: NLRP3 Inflammasome as a Key Mediator in the Intersection of Depression and Cardiovascular Disease – A Narrative Review
Authors: Jahromi Ghazaleh Ghaffaripour , Rezaei Nima 
Published: January 2025

Abstract
Cardiovascular diseases (CVDs) are the leading cause of mortality worldwide and frequently coexist with depressive disorders. The consequence of their concurrence is the exacerbation of both conditions. Numerous studies seek to understand the pathophysiological connection between this mental disorder and CVDs, and theories such as autonomic dysfunction, endocrine dysregulation, platelet dysfunction, and inflammation have been suggested. However, in this review, we propose that these theories are all related and that etiology of both diseases can be explained by the involvement of the nucleotide-binding oligomerization domain-, leucine-rich repeat-, and pyrin domain-containing protein 3 (NLRP3) inflammasome-mediated inflammation. To elucidate, we investigate the inflammasome contribution to the central nervous system (CNS), the vasculature, the heart, and the autonomic nervous system. We presented evidence of neurotransmitter imbalances, hypothalamic pituitary adrenal axis dysregulation, microglial activation, and inflammatory damage to the CNS. We put forward the research on NLRP3 activation showing vascular damage that could alter the brain blood barrier, cause endothelial dysfunction, alter lipid metabolism, hypertension, atherosclerosis, aneurisms, and hypercoagulable states. Similarly, we explore its involvement in the development of heart failure, cardiac remodeling, myocardial infarction, cardiac arrythmias, and hyperactive tuning of the sympathetic response.
Cardiovascular Benefits of Dance as a Unique Form of Exercise: A Literature Review
Authors: Tatavarthy Manvita , Oktay Ahmet Afşin 
Published: January 2025

Abstract
Physical activity has well-known benefits in improving multiple risk factors that lead to cardiovascular disease. Dance is a unique form of exercise that is often accessible and modifiable according to the individual’s cultural background and physical abilities. It can increase physical activity levels by creating social engagement. Limited data from intervention studies with small sample sizes and short duration or follow-up suggested that routine participation in dance can improve agility and balance, leading to decreased rates of immobility and depression, which may act as an independent risk factor for cardiovascular disease. It may also assist with blood pressure control in patients with hypertension. Moreover, dance training may improve cardiorespiratory symptoms in individuals with or without heart failure. Studies also suggested that culturally sensitive dance programs may enhance participation and retention of physical activity in various ethnic groups and women. Future research is needed to understand better the potential long-term cardiovascular benefits of dance training and the feasibility of implementing these programs to improve cardiovascular health in special populations.
Association of diabetes mellitus with long-term prognosis after ablation therapy for patients with hepatocellular carcinoma: A single-center cohort study
Authors: Wang Neng , Shen Qiang , Zhou Ping-Sheng , Wang Ming-Da , Zhang Jing-Lei , Sheng Yue-Hong , Qian Guo-Jun 
Published: January 2025

ABSTRACT

Background:
This study investigated the clinical efficacy and prognostic factors of ablative treatment in hepatocellular carcinoma (HCC) patients with and without diabetes mellitus (DM).

Methods:
Retrospective data were collected from HCC patients who underwent ablation between January 2016 and December 2019. The baseline clinicopathological characteristics and long-term outcomes, such as overall survival (OS) and recurrence-free survival (RFS), were compared between those with and without DM. Predictive factors associated with survival and recurrence were identified through univariable and multivariable Cox regression analyses.

Results:
Of the 3528 patients enrolled in the study, 588 (16.7%) had concurrent DM. The 1-, 3-, and 5-year RFS rates in patients with DM (73.8%, 33.7%, and 5.8%, respectively) were significantly (P < 0.001) lower than those in the non-DM patients (70.4%, 37.6%, and 18.6%, respectively). Likewise, significant differences (P < 0.001) in the 1-, 3-, and 5-year OS rates were observed between the DM (99.9%, 78.1%, and 29.1%, respectively) and non-DM (99.9%, 85.9%, and 54.3%, respectively) patients. Multivariable Cox regression analysis identified DM as an independent risk factor for OS [hazard ratio (HR), 1.982; P < 0.001] and RFS (HR, 1.175; P = 0.002).

Conclusion:
Patients with DM exhibited a poorer oncological prognosis than those without DM following ablation for HCC. DM was identified as an independent factor influencing the prognosis of HCC patients after curative ablation. Thus, active therapies targeting DM might enhance oncological outcomes and facilitate individualized treatment decisions.
Elevated CA19-9 within the normal range suggests poorer prognosis in stage II CRC: A retrospective analysis of a large sample in a single center
Authors: Zhang Ruoxin , Chen Fan , Weng Junyong , Ye Zilan , Li Xinxiang 
Published: January 2025

ABSTRACT

Objective:
Carbohydrate antigen 19-9 (CA19-9) and carcinoembryonic antigen (CEA) serve as pivotal tumor markers in colorectal cancer (CRC). However, uncertainty persists regarding the prognostic significance of the two tumor markers when falling within the normal range. We attempt to compare the prognostic differences of tumor markers at different levels within the reference range.

Methods:
This retrospective study scrutinized 2,167 cases of stage II CRC verified by pathology after surgery at the Fudan University Shanghai Cancer Center. Using R software to calculate the optimal critical value to compare the clinical and pathological characteristics and prognosis of different levels of tumor markers. The survival and regression modeling strategies packages of R software drew the nomograms.

Results:
Utilizing R software, the optimal critical value of CA19-9 was determined as 12.12 U/mL and that of CEA as 1.89 U/mL. Kaplan-Meier survival analysis unveiled that, within the normal range, higher levels of CEA were linked to poorer overall survival (OS) [HR = 1.829 (1.280, 2.989), P = 0.0033] and disease-free survival (DFS) [HR = 1.472 (1.114, 1.944), P = 0.0444]. Similarly, heightened levels of CA19-9 also indicated inferior OS [HR = 1.750 (1.203, 2.455), P = 0.0076] and DFS [HR = 1.361 (1.098, 1.686), P = 0.0049]. Furthermore, multivariate analysis identified CA19-9 as an independent risk factor for OS (HR = 1.49,95% CI: 1.086–2.045, P = 0.014) and DFS (HR = 1.327,95% CI: 1.070–1.647, P = 0.01), while the impact of CEA on OS and DFS was not statistically significant. A nomogram constructed based on the Cox regression model can effectively evaluate the prognosis of CRC patients.

Conclusion:
Although within the normal range, elevated CA19-9 was associated with an inferior prognosis, chemotherapy decisions of different intensities can be adjusted based on nomograms. This work will contribute to standardizing the diagnosis and treatment of stage II CRC and provide clinicians with essential insights for chemotherapy decisions.
The role of fecal microbiota transplantation in the treatment of acute graft-versus-host disease
Authors: Guo Zhi , He Mingxin , Shao Liang , Li Yue , Xiang Xiaochen , Wang Qiang 
Published: January 2025

ABSTRACT
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is one of the most important methods for treating a wide range of hematologic malignancies and bone marrow failure diseases. However, graft-versus-host disease (GVHD), a major complication associated with this method, can seriously affect the survival and quality of life of patients. Acute GVHD (aGVHD) occurs within 100 days after transplantation, and gastrointestinal aGVHD (GI-aGVHD) is one of the leading causes of nonrecurrent death after allo-HSCT. In recent years, fecal microbiota transplantation (FMT) has been attempted as an emerging treatment method for various diseases, including aGVHD after HSCT. Studies have shown encouraging preliminary clinical results after the application of FMT in aGVHD, particularly steroid-resistant aGVHD. Additionally, several studies have demonstrated that the gut microbiota plays an important immunomodulatory role in the pathogenesis of GVHD. Consensus guidelines recommend FMT as a secondary option for the treatment of aGVHD. This article aims to review FMT treatment for GI-aGVHD after allo-HSCT.
Clinical features and prognosis analysis of stage III/IV patients with lung cancer after treatment with toripalimab: A real-world retrospective
Authors: Wang Chenlin , Liang Ning , Qiao Lili , Wu Ya’nan , Zhang Jiandong , Zhang Yan 
Published: January 2025

ABSTRACT

Aim:
Toripalimab is the first antitumor programmed cell death protein 1 (PD-1) antibody approved in China. For better patient management, it is important to understand the real-world outcomes of toripalimab in treating patients with lung cancer in the real world outside of clinical trials to improve patient care.

Methods:
We retrospectively examined the clinical data of 80 patients with lung cancer who received the PD-1 inhibitor (toripalimab). The Chi-square test was performed to identify clinical factors associated with the advancement of the disease. Multivariate Cox regression analysis was used to screen prognostic variables linked to real-world progression-free survival (PFS) and overall survival (OS). OS and PFS were calculated using the Kaplan-Meier method, and the comparisons were determined using the log-rank test, and continuous and categorical variables were explained using median and percentage, respectively.

Result:
The median OS of the estimated 80 patients was 15.85 months (95% confidence interval [CI]: 14.103–17.949 months), and the estimated PFS was 5.650 months (95% CI: 7.226–11.264 months). The longer OS and PFS correlate with the patient’s staging and number of treatment lines. The PD-1 drug gave stage III patients a significantly longer PFS and OS compared to stage IV patients (PFS: 14.65 vs. 6.68, P = 0.004; OS: 21.1 vs. 13.7, P = 0.003). First- or second-line immunotherapy patients have significantly longer PFS and OS than third- or fourth-line (PFS: 6.4 vs. 3.6, P = 0.009; OS: 20.0 vs. 10.5, P = 0.003). In patients with stage IV (n = 60) with extensive metastasis, the site of metastasis is mostly 1–3 sites after receiving toripalimab. The duration of PD-1 inhibitor OS in progressive patients (n = 56) was significantly prolonged (P = 0.038).

Conclusion:
For patients with lung cancer, toripalimab can considerably extend PFS and OS in the first or second line and in stage III. PD-1 inhibitors are administered to patients with stage IV extensively metastatic lung cancer, which indicates an oligometastatic progression pattern, primarily in 1–3 locations, who are treated with PD-1 inhibitors. Continuing toripalimab beyond disease progression significantly prolonged OS.
Apatinib and trastuzumab-based chemotherapy for heavily treated primary trastuzumab-resistant metastatic breast cancer
Authors: Chen Xuelian , Huang Jiayi , Xie Xiaofeng , Chen Liping , Lan Xiaofeng , Song Lin , Bai Xue , Du Caiwen 
Published: January 2025

ABSTRACT

Background:
The low incidence and poor prognosis primary trastuzumab resistance (PTR) in HER2-positive breast cancer has limited research into possible treatments. Thus, it remains unclear whether this group of patients could benefit from nontargeting HER2 antiangiogenic therapy.

Patients and Methods:
We collected the medical data for HER2-positive patients with PTR who received apatinib 250 mg and trastuzumab-based chemotherapy (ATBC) between March 18, 2017, and March 31, 2022. All patients had progressed on ≥2 anti-HER2 treatments, including trastuzumab and small molecular tyrosine kinase inhibitors. We evaluated tumor response and safety profiles to ATBC over a median follow-up time of 34.5 months.

Results:
A total of 198 consecutively HER2-positive metastatic breast cancer patients were reviewed; 20 were PTR and received ATBC. The clinical benefit rate of the total cohort was 55.0%. No patient showed a complete response. The median PFS and overall survival (OS) of the entire cohort was 5.7 months (95% CI 2.9–8.5) and 24.6 months (95% CI 6.9–42.4), respectively. The estimated 2-year survival rate was 46.7% (95% CI 38.4–81.6%). The most common nonhematologic adverse events were hypertension (70.0%), hand-foot skin reaction (55.0%), proteinuria (40.0%), and cardiovascular decrease of LVEF (20.0%). No new toxicities were observed.

Conclusion:
ATBC had favorable effects for PTR breast cancer patients in later line treatment. The toxicity of the triple-combination regimen was tolerable; thus, further research should focus on identifying PTR patients who could benefit from ATBC.
Body Mass Index’s Role in Determining Maximum Mouth Opening Using the Three-Finger Index in People of Aligarh city, Uttar Pradesh
Authors: Verma Pradhuman , Verma Kanika Gupta , Das Abhinaba , Najmuddin Mohammed , Khan Naseebia , Ahmed Muzammil Moin 
Published: January 2025

Background:
Mouth opening is significant for diagnosing many clinical conditions. Therefore, it becomes essential to establish normal maximum mouth opening (MMO).

Aim:
To study role of BMI while evaluating MMO using three-finger index.

Materials and Method:
A total of 500 subjects between 20 and 60 years were considered. Thorough clinical examination was done. Subjects satisfying inclusion criteria, height (H) and weight (W) were recorded, and BMI was calculated as W/H2. Group I included under-weight (18.5 and less) subjects, Group II: normal (18.5 to 24.9), Group III: over-weight (25–29.9), and Group IV: subjects with obesity (≥30), based on BMI. Inter-incisal MMO and combined three-finger (index, middle and ring finger) width of both hands were also measured for each subject. To avoid bias, measurements were taken twice by same observer and mean was considered.

Result:
Maximum subjects were found in Group II and minimum in Group I. MMO was noted highest in Group III with significantly higher values in males. Both hand fingers’ width was noted maximum in Group IV again with significantly higher values among males. Statistically significant correlation (P < 0.05) was found between three-finger width and MMO in all groups.

Conclusion:
BMI while measuring three-finger width of hands was found to be significantly correlated with MMO in Aligarh population and may be a significant indicator of MMO.
Brief Pain Inventory and McGill Pain Questionnaire in Assessing the Patients with Temporomandibular Joint Disorders – A Cross-Sectional Study
Authors: Selvam Keerthana , Kumar J Anand , Lakshmi Suman J. , Balasubramanian Senthil Kumar 
Published: January 2025

Background:
The temporomandibular joint, where the mandible articulates with the skull, is renowned for its complexity. Temporomandibular disorders (TMDs) are the second most prevalent musculoskeletal affliction, causing pain and disability, underscoring their impact on well-being.

Objective:
To assess the efficacy of the Brief Pain Inventory and McGill Pain Questionnaire in TMD pain evaluation.

Material and Methods:
This study included 100 patients diagnosed with TMD who were asked to complete two questionnaires: the Brief Pain Inventory and the McGill Pain Questionnaire; the responses provided by the patients were collected and subjected to statistical analysis.

Results:
Among a cohort of 100 patients, the mean values for the duration and intensity of pain associated with TMD using Brief Pain Inventory manifested statistical significance, underscored by a P value of 0.001. The mean values of the Pain Rating Index and Present Pain Intensity, as determined through the McGill Pain Questionnaire across the study population, exhibited statistical significance, registering a P value of 0.001.

Conclusion:
The Brief Pain Inventory is most useful when compared with the McGill pain questionnaire in assessing the pain in patients with TMD.
A Rare Case Report of Multisystem Langerhans Cell Histiocytosis in a Young Adult
Authors: Malhotra Kajal , Vohra Puneeta , Arya Varun , Yadav Anuradha 
Published: January 2025

Abstract
This is a rare case report of a young adult with oral manifestations of Langerhans cell histiocytosis (LCH). The initial symptom was localized severe bone loss in the mandible. Subsequently, thorough investigations led to a definitive diagnosis of multisystem LCH, a very rare histiocytic neoplasia. The relevance of more recent imaging modalities in the timely diagnosis and treatment of these uncommon lesions is also highlighted in our case study.
Morphometry of the Bicipital Groove Revisited: A Radiographic Study
Authors: Alslehat Ruba Ahmad , Alshatarat Amjad T. , Samara Osama A. , Badran Darwish H. 
Published: January 2025

Abstract

Background:
With increased prevalence of proximal humeral fractures, providing a precise assessment of different measurements for the bicipital groove and testing the gender differences on the same side bicipital groove in addition between different sides on the same gender become mandatory.

Methodology:
Three hundred and ten shoulder magnetic resonance imaging scans were used in this study, these scans obtained from January 2020 to December 2021. These images include; 155 for males and the same number for females, 190 for the right side in addition 120 for the left side. Statistical Package for Social Science (SPSS) were used to analyze the data, independent t-test was conducted, P < 0.05 was decided to be statistically significant.

Results:
There was significant difference (P < 0.05) between different genders in terms of depth and width of bicipital groove, distance between greater and lesser tubercles. In addition, significant difference found between different sides in terms of depth of intertubercular groove and the distance between tubercles.

Conclusion:
As a result of variations among different population, obtaining an accurate morphometry of proximal humerus has become important to mimic the anatomy of the proximal humerus. Moreover, the difference between the intertubercular groove among different genders could be helpful in forensic medicine.