bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of the outcomes of three different cross‐linking protocols for treatment of paediatric keratoconus: A multicentre randomized controlled trial
Authors: Iqbal Mohammed , Gad Ahmed , Kotb Ahmed , Abdelhalim Mahmoud 
Published: May 2023

AbstractPurposeTo analyse long‐term outcomes of standard cross‐linking (SCXL), accelerated cross‐linking (ACXL) and transepithelial cross‐linking (TCXL) in the treatment of progressive paediatric keratoconus regarding stability, safety and efficacy.MethodsThis prospective multicentre randomized controlled trial included 97 eyes of 97 paediatric patients with stages I–III ABCD keratoconus grading system, who were randomized into three groups; SCXL group (control group, n = 32; 3 mW/cm2 × 30 min/5.4 J/cm2), ACXL (n = 33; 18 mW/cm2 × 5 min/5.4 J/cm2) and TCXL (n = 32; 18 mW/cm2 × 5 min/5.4 J/cm2). Subjective refraction, uncorrected and corrected visual acuity, keratometry and pachymetry measurements using corneal topography were recorded preoperatively and 1, 2 and 3 years postoperatively.ResultsSCXL group exhibited significant successive improvements in the mean visual, refractive and keratometric parameters throughout the entire postoperative 3 years while ACXL group exhibited significant improvements in visual and keratometric parameters in the first postoperative year that remained stable in second and third postoperative years. TCXL group exhibited significant progressive deterioration in all mean parameters compared to SCXL and ACXL (p < 0.0001). Both SCXL and ACXL revealed final 100% success rate with good stability while TCXL revealed final 22% failure rate with keratoconus progression (p < 0.0001).ConclusionSCXL and ACXL were comparable in halting keratoconus progression and achieved good stability and safety; however, SCXL was more efficient than ACXL as it yielded greater significant postoperative mean visual, refractive and keratometric improvements achieving smoother corneal remodelling. Both SCXL and ACXL were much superior to TCXL. SCXL is the best CXL treatment option for paediatric keratoconus while ACXL is a good and effective alternative.
Exploring the effect of socially responsible human resource management on employee resilience: The role of basic psychological needs and collectivism
Authors: Shao Dan‐Ping , Peng Yun , Ji Yang 
Published: May 2023

AbstractResilience has become a topic of renewed interest due to the frequent difficulties encountered by organisations and individuals in the present turbulent world. It is widely recognised that HRM practices play a crucial role in stimulating employee resilience. However, only few studies have explored the role of socially responsible human resource management (SRHRM) in enhancing employee resilience. Accordingly, our study aims to address this research gap by utilising self‐determination theory to develop a theoretical model clarifying the effect of SRHRM on employee resilience, focusing on the mediating role of basic psychological needs. Furthermore, we identify collectivism as a critical moderating factor in the relation between SRHRM and employee resilience. For this purpose, data were collected from 355 employees in central China in three waves. Results revealed that SRHRM can enhance employee resilience by fulfilling basic psychological needs. Moreover, the results indicated that collectivism strengthens the indirect relation between SRHRM and employee resilience through the fulfilment of basic psychological needs.
Biases and distribution patterns in hard‐bodied microscopic animals (Acari: Halacaridae): Size does not matter, but generalism and sampling effort do
Authors: Rubio‐López Iñigo , Pardos Fernando , Fontaneto Diego , Martínez Alejandro , García‐Gómez Guillermo 
Published: May 2023

AbstractAimThe interplay between distribution ranges, species traits and sampling and taxonomic biases remains elusive amongst microscopic animals. This ignorance obscures our understanding of the diversity patterns of a major component of biodiversity. Here, we used marine Halacaridae to explore whether differences between marine provinces can explain their distribution patterns or if differential sampling efforts across regions prevent any macroecological inference. Furthermore, we test if certain functional traits influence their distribution patterns.LocationEurope.ResultsWhereas geographical variables provided a better explanation for differences in species composition, sampling effort and distance from marine biological stations accounted for the majority of differences in European Halacaridae richness. Species occurring in more habitats showed broader geographical ranges and accumulated more records. Species traits like generalism affected the distribution of halacarid species.Main ConclusionsWe propose that the sampling effort of halacarid mites in Europe might be explained by two different cognitive biases: the convenience of selecting certain sampling localities compared to others and the tendency of zoologists to scrutinise habitats where their target organisms are more common.
Trends in incidence of ischaemic stroke in people with and without diabetes in Ireland 2005–2015
Authors: Bambury Niamh , O'Neill Kate , Buckley Claire M. , Kearney Patricia M. 
Published: May 2023

AbstractAimsWe aim to describe the epidemiology of ischaemic stroke and in‐hospital mortality associated with stroke among men and women with and without diabetes from 2005 to 2015.MethodsSecondary data analysis of national hospital discharge data from the Hospital Inpatient Enquiry database. Stroke incidence and in‐hospital mortality rates in people with and without diabetes were calculated. Poisson regression models were used to estimate the incidence rate ratio (IRR) and assess trends over time.ResultsThe age‐adjusted incidence of stroke was twice as high in people with diabetes compared to those without diabetes (men IRR 2.0 [95% CI 1.95–2.06] and women IRR 2.2 [95% CI 2.12–2.27]). The incidence of ischaemic stroke decreased by an average 1.7% per year in men with diabetes and 3.3% per year in women with diabetes. In people without diabetes, the average annual reduction was smaller (0.2% per year in men and 1% per year in women). In‐hospital mortality associated with admission with ischaemic stroke was approximately twice as high in those with diabetes compared to those without diabetes among men [IRR 1.81 (1.67–1.97)] and women [IRR 2 (95% CI 1.84–2.18)].ConclusionDespite decreases in incidence of ischaemic stroke and associated in‐hospital mortality, there remains a twofold increased risk of ischaemic stroke and mortality in people with diabetes. Therefore, priority must be given to management of risk factors for ischaemic stroke in people with diabetes as well as continued development of targeted stroke prevention strategies.
Confocal microscopy and optical coherence tomography of inflammatory skin diseases in hairs and pilosebaceous units: A systematic review
Authors: Al‐Chaer Rami Nabil , Bouazzi Dorra , Jemec Gregor , Mogensen Mette 
Published: May 2023

AbstractCommon skin disorders such as acne vulgaris, rosacea and folliculitis are bothersome prevalent inflammatory diseases of hair follicles that can easily be investigated bedside using optical coherence tomography (OCT) and reflectance confocal microscopy (RCM) with micrometre resolution, opening a novel era for high‐resolution hair follicle diagnostics and quantitative treatment evaluation. EMBASE, PubMed and Web of Science were searched until 5 January 2023 to identify all studies imaging hair follicle characteristics by RCM and OCT for diagnosis and monitoring of treatment in hair follicle‐based skin disorders. This study followed PRISMA guidelines. After inclusion of articles, methodological quality was assessed using the QUADAS‐2 critical appraisal checklist. Thirty‐nine in vivo studies (33 RCM and 12 OCT studies) were included. The studies focused on acne vulgaris, rosacea, alopecia areata, hidradenitis suppurativa, folliculitis, folliculitis decalvans, lichen planopilaris, discoid lupus erythemasus, frontal fibrosing alopecia and keratosis pilaris. Inter‐ and perifollicular morphology including number of demodex mites, hyperkeratinization, inflammation and vascular morphology could be assessed by RCM and OCT in all included skin disorders. Methodological study quality was low, and interstudy outcome variability was high. Quality assessment showed high or unclear risk of bias in 36 studies. Both RCM and OCT visualize quantitative features as size, shape, content and abnormalities of hair follicles, and have potential to support clinical diagnosis and evaluate treatment effects. However, larger studies with better methodological quality are needed to implement RCM and OCT directly into clinical practice.
Normal glymphatic system function in patients with new daily persistent headache using diffusion tensor image analysis along the perivascular space
Authors: Zhang Xue , Wang Wei , Zhang Xueyan , Bai Xiaoyan , Yuan Ziyu , Zhang Peng , Bai Ruiliang , Jiao Bingjie , Zhang Yingkui , Li Zhiye , Tang Hefei , Zhang Yaqing , Yu Xueying , Wang Yonggang , Sui Binbin 
Published: May 2023

AbstractObjectivesTo investigate the glymphatic function in patients with new daily persistent headache (NDPH) using the diffusion tensor image analysis along the perivascular space (DTI‐ALPS) method.BackgroundNDPH, a rare and treatment‐refractory primary headache disorder, is poorly understood. There is limited evidence to suggest that headaches are associated with glymphatic dysfunction. Thus far, no studies have evaluated glymphatic function in patients with NDPH.MethodsIn this cross‐sectional study conducted in the Headache Center of Beijing Tiantan Hospital, patients with NDPH and healthy controls were enrolled. All participants underwent brain magnetic resonance imaging examinations. Clinical characteristics and neuropsychological evaluation were examined in patients with NDPH. ALPS indexes for both hemispheres were measured to determine the glymphatic system function in patients with NDPH and healthy controls.ResultsIn total, 27 patients with NDPH (14 males, 13 females; age [mean ± standard deviation (SD)]: 36.6 ± 20.6) and 33 healthy controls (15 males, 18 females; age [mean ± SD]: 36.0 ± 10.8) were included in the analysis. No significant differences between groups were observed in the left ALPS index (1.583 ± 0.182 vs. 1.586 ± 0.175, mean difference = 0.003, 95% confidence interval [CI] of difference = −0.089 to 0.096,p = 0.942), or right ALPS index (1.578 ± 0.230 vs. 1.559 ± 0.206, mean difference = −0.027, 95% CI of difference = −0.132 to 0.094,p = 0.738). Additionally, ALPS indexes were not correlated with clinical characteristics or neuropsychiatric scores.ConclusionNo glymphatic dysfunction was detected in patients with NDPH by means of the ALPS method. Additional studies with larger samples are needed to confirm these preliminary findings and improve the understanding of glymphatic function in NDPH.
Giant juvenile fibroadenomas with and without prominent pseudoangiomatous stromal hyperplasia (PASH)‐like change: clinicopathological and molecular characteristics
Authors: Jorns Julie M , Farooq Ayesha , Puzyrenko Andrii , Jarzembowski Jason , Thike Aye Aye , Nasir Nur Diyana Md , Ng Cedric Chuan Young , Liu Wei , Lee Jing Yi , Lim Abner Herbert , Guan Peiyong , Teh Bin Tean , Tan Puay Hoon 
Published: May 2023

AimsJuvenile fibroadenomas (JFA) are biphasic fibroepithelial lesions (FEL) usually occurring in adolescent female patients. Giant (G) JFA, like other FEL, may exhibit prominent pseudoangiomatous stromal hyperplasia (PASH)‐like change. We sought to determine clinicopathological and molecular characteristics of GJFA with and without PASH.Methods and resultsArchives were searched for cases of GJFA (1985–2020). All were stained for androgen receptor (AR), beta‐catenin, CD34 and progesterone receptor (PR). Cases were sequenced using a custom 16‐gene panel – MED12 (exons 1 and 2), TERT promoter (–124C>T and –146Ctable>T), SETD2, KMT2D, RARA (exons 5–9), FLNA, NF1, PIK3CA (exons 10, 11 and 21), EGFR, RB1, BCOR, TP53, PTEN, ERBB4, IGF1R and MAP3K1. Twenty‐seven GJFA from 21 female patients aged 10.1–25.2 years were identified. Size ranged from 5.2 to 21 cm. Two patients had multiple, bilateral and later recurrent GJFA. Thirteen (48%) cases showed prominent PASH‐like stroma. All were positive for stromal CD34, negative for AR and beta‐catenin and one case showed focal PR expression. Sequencing showed MAP3K1 and SETD2 mutations in 17 samples, with KMT2D, TP53 and BCOR aberrations in 10 (45%), 10 (45%) and seven (32%) cases, respectively. Tumours with a PASH‐like pattern had higher prevalence of SETD2 (P = 0.004) and TP53 (P = 0.029) mutations, while those without PASH had more RB1 mutations (P = 0.043). MED12 mutation was identified in one case. TERT promoter mutation was observed in four (18%), including two recurrences.ConclusionsGene mutations along more advanced phases of the proposed FEL pathogenetic pathway in GJFA are unusual, and suggest a mechanism for more aggressive growth in these tumours.
Missed opportunities: saving lives through organ donation following voluntary assisted dying
Authors: Ray Robert , Martin Dominique 
Published: May 2023

AbstractOrgan donation after voluntary assisted dying (VAD) in Australia may potentially increase organ transplant rates. Despite significant international experience with donation after VAD, there has been little discussion of this in Australia. We review potential ethical and practical concerns relating to donation after VAD and advocate action to establish programmes in Australia that ensure safe, ethical and effective donation after VAD.
Perilesional injections of human platelet lysate versus platelet poor plasma for the treatment of diabetic foot ulcers: A double‐blinded prospective clinical trial
Authors: Alhawari Hussam , Jafar Hanan , Al Soudi Mohammad , Ameereh Lena Abu , Fawaris Maram , Saleh Mohanad , Aladwan Safwan , Younes Nidal , Awidi Abdalla 
Published: May 2023

AbstractDiabetic foot ulcer (DFU) is a major cause of morbidity, non‐traumatic lower limb amputation in diabetic patients and a high‐cost burden on the healthcare system. New therapeutic products are increasingly tested. Platelet‐rich plasma (PRP) and human platelet lysate (hPL) are reported to be useful. This trial was conducted to test whether the healing effect of hPL in chronic DFU was due to plasma or platelet lysates in a prospective double‐blind design. Autologous PRP was obtained from citrated blood, lysed, and used as drug 1 (active product). The platelet‐poor plasma (PPP) was used as a drug 2 (placebo). Ten patients were enrolled in arm 1 and 9 in arm 2. The drugs were injected perilesionally every 2 weeks for a total of sixinjections. Adverse events were recorded until Week 14. The DFUs were scored per the Texas and Wegner systems. No patient showed any major adverse events. Some reported local pain post‐injection. Wound healing was achieved in the hPL group in 9/10 of patients at a mean of 35.1 days. In the PPP group, no patient had healed by Day 84. The difference was statistically significant at P < 0.00001. We conclude that autologous hPL is safe and highly effective in healing chronic DFU and is superior to autologous PPP.
Effects of magnesium on the structure of aluminoborosilicate glasses: NMR assessment of interatomic potentials models for molecular dynamics
Authors: Bertani Marco , Bisbrouck Nicolas , Delaye Jean‐Marc , Angeli Frédéric , Pedone Alfonso , Charpentier Thibault 
Published: May 2023

AbstractClassical molecular dynamics simulations have been used to investigate the structural role of Mg and its effect when it is incorporated in sodium aluminoborosilicate glasses. The simulations have been performed using three interatomic potentials; one is based on the rigid ionic model parameterized by Wang et al. (2018) and two slightly different parameterization of the core–shell model provided by Stevensson et al. (2018) and Pedone et al. (2020) The accuracies of these models have been assessed by detailed structural analysis and comparing the simulated nuclear magnetic resonance (NMR) spectra for spin active nuclei (29Si, 27Al, 11B, 17O, 25Mg, and 23Na) with the experimental counterparts collected in a previous work. Our simulations reveal that the core–shell parameterizations provide better structural models. In fact, they better reproduce the NMR spectra of all the investigated nuclei and give better agreement with known experimental data. Magnesium is found to be five coordinated on average with distances with oxygen in between a network modifier (like Na) and an intermediate network formed (like Al). It prefers to lay closer to three‐coordinated B atoms, forming B–NBO bonds, with respect to Si and especially Al. This can explain the formation of AlO5 and AlO6 units in the investigated Na‐free glass, together with a Si clusterization.
The peak‐shift method for the description of structural relaxation in glassy materials: a critical review
Authors: Svoboda Roman 
Published: May 2023

AbstractNowadays, the glass transition kinetics is most commonly described in terms of the Tool–Narayanaswamy–Moynihan (TNM) model. Evaluation of one of the most prominent features of the structural relaxation motions—the relaxation nonlinearity—was traditionally done using the peak‐shift (PS) method. This paper introduces, for the first time, extensive testing of the PS method by means of theoretical simulations for all practically observable types of structural relaxation behavior and all types of glassy/amorphous materials (tested range of the glass transition temperatures: −55 to 1000°C; tested range of the relaxation activation energies: 300–1300 kJ⋅mol−1). For the majority of types of structural relaxation behavior, the PS method tends to slightly overestimate the value of the TNM nonlinearity parameter x (by ∼ 0.05–0.10). In the specific cases of the highly linear behavior (↑ x) combined with a broad distribution of relaxation times, the PS method systematically vastly underestimates the value of x. A new, improved temperature program was proposed for the PS method, eliminating the major intrinsic drawback of the originally proposed version of the PS methodology. In addition, based on the comparison between the theoretically simulated and real‐life experimental data, a new approach (based on the characteristic PS dependence shape) was introduced to estimate the width of the relaxation times distribution.
Effect of weight loss on blood pressure changes in overweight patients: A systematic review and meta‐analysis
Authors: Yang Shijie , Zhou Zhanyang , Miao Huanhuan , Zhang Yuqing 
Published: May 2023

AbstractTo determine quantitative differences between weight loss and changes in clinic blood pressure (BP) and ambulatory BP in patients with obesity or overweight, the authors performed a meta‐analysis. PubMed, Embase, and Scopus databases were searched up to June 2022. Studies that compared clinic or ambulatory BP with weight loss were included. A random effect model was applied to pool the differences between clinic BP and ambulatory BP. Thirty‐five studies, for a total of 3219 patients were included in this meta‐analysis. The clinic systolic blood pressure (SBP) and diastolic blood pressure (DBP) were significantly reduced by 5.79 mmHg (95% CI, 3.54–8.05) and 3.36 mmHg (95% CI, 1.93–4.75) after a mean body mass index (BMI) reduction of 2.27 kg/m2, and the SBP and DBP were significantly reduced by 6.65 mmHg (95% CI, 5.16–8.14) and 3.63 mmHg (95% CI, 2.03–5.24) after a mean BMI reduction of 4.12 kg/m2. The BP reductions were much larger in patients with a BMI decrease ≥3 kg/m2 than in patients with less BMI decrease, both for clinic SBP [8.54 mmHg (95% CI, 4.62–12.47)] versus [3.83 mmHg (95% CI, 1.22–6.45)] and clinic DBP [3.45 mmHg (95% CI, 1.59–5.30)] versus [3.15 mmHg (95% CI, 1.21–5.10)]. The significant reduction of the clinic and ambulatory BP followed the weight loss, and this phenomenon could be more notable after medical intervention and a larger weight loss.
A prospective study of the relative contribution of adolescent peer support quantity and quality to depressive symptoms
Authors: Letkiewicz Allison M. , Li Lilian Y. , Hoffman Lija M.K. , Shankman Stewart A. 
Published: May 2023

BackgroundDuring adolescence, peer support has an increasingly important role in identity formation and well‐being. Prior research has identified that lack of social support from peers in adolescence is a potent risk factor for depression. Two ways that social support has been operationalized is by the number of one's friends (i.e., ‘quantity’) and perception of one's network (i.e., ‘quality’). Typically, these aspects of peer support are assessed separately.MethodsUsing data from the National Longitudinal Study of Adolescent to Adult Health (N = 3,857), this study sought to test whether (1) adolescent depression relates to having fewer friends versus lower quality friendships, (2) these aspects of adolescent peer support prospectively predict depression in adulthood, (3) gender moderates the effects of peer support on depression, and (4) these aspects of peer support buffer the effects of stressful life events on depression.ResultsPeer support quality uniquely predicted depression in adolescence and adulthood among both males and females. The effect of peer support quality on depressive symptoms, however, was greater for females than males. By contrast, peer support quantity did not uniquely predict depression for males or females.ConclusionsQualitative aspects of adolescent peer support uniquely contribute to mental health not only in adolescence, but in adulthood as well. Potential processes through which peer support relates to depression are discussed, as well as implications for treatment.
Evaluation of an electronic medical record−based Paediatric Nutrition Screening Tool
Authors: Hilbrands Julia , Feuling Mary Beth , Szabo Aniko , Teng Bi Q. , Burgess Chandler , Clark Brittani , Crouse Jennifer , Fortin Heather , Heisler Becky , Karls Catherine , Lampone Olivia , Matschull Lauren , Seyfert Marissa , Smith Amber , Goday Praveen S. 
Published: May 2023

AbstractBackgroundNutrition screening is recommended to identify children at risk for malnutrition. A unique screening tool was developed based on American Society for Parenteral and Enteral Nutrition (ASPEN) recommendations and embedded in the electronic medical record to assess for nutrition risk.MethodsThe components of the tool included the Paediatric Nutrition Screening Tool (PNST) and other elements recommended by ASPEN. To evaluate the screening tool, retrospective data were analysed on all patients admitted to acute care units of Children's Wisconsin in 2019. Data collected included nutrition screen results, diagnosis and nutrition status. All patients who received at least one full nutrition assessment by a registered dietitian (RD) were included in analysis.ResultsOne thousand five hundred seventy‐five patients were included in analysis. The following screen elements were significantly associated with a diagnosis of malnutrition: any positive screen (p < 0.001), >2 food allergies (p = 0.009), intubation (p < 0.001), parenteral nutrition (p = 0.005), RD‐identified risk (p < 0.001), positive risk per the PNST (p < 0.001), BMI‐for‐age or weight‐for‐length z‐score (p < 0.001), intake <50% for 3 days (p = 0.012) and NPO > 3 days (p = 0.009). The current screen had a sensitivity of 93.9%, specificity of 20.3%, positive predictive value (PPV) of 30.9% and negative predictive value (NPV) of 89.8%. This is compared with the PNST which had a sensitivity of 32%, specificity of 94.2%, PPV of 71% and NPV of 75.8% in this study population.ConclusionThis unique screening tool is useful for predicting nutrition risk and has a greater sensitivity than the PNST alone.