bluuebunny/crossref_metadata_2025_split huggingface dataset:
Integrated and Bifunctional Bilayer 3D Printing Scaffold for Osteochondral Defect Repair
Authors: Li Cairong , Zhang Wei , Nie Yangyi , Jiang Dongchun , Jia Jingyi , Zhang Wenjing , Li Long , Yao Zhenyu , Qin Ling , Lai Yuxiao 
Published: March 2023

AbstractBioinspired scaffolds with two distinct regions resembling stratified anatomical architecture provide potential strategies for osteochondral defect repair and are studied in preclinical animals. However, delamination of the two layers often causes tissue disjunction between the regenerated cartilage and subchondral bone, leading to few commercially available clinical applications. This study develops an integrated poly(ε‐caprolactone) (PCL)‐based scaffold for repairing osteochondral defects. An extracellular matrix (ECM)‐incorporated 3D printing composite scaffold (ECM/PCL) coated with ECM hydrogel (E‐co‐E/PCL) is fabricated as the upper layer, and magnesium oxide nanoparticles coated with polydopamine (MgO@PDA)‐incorporated composite scaffold (MD/PCL) is fabricated using 3D printing as the bottom layer. The physicochemical and mechanical properties of the bilayer scaffold meet the requirements in designing and fabricating the osteochondral scaffold, especially a strong interface possessed between the two layers. By in vitro study, the integrated scaffold stimulates proliferation, chondrogenic differentiation, and osteogenic differentiation of human bone mesenchymal stem cells. Moreover, the integrated bilayer scaffold exhibits well repair ability to facilitate simultaneous regeneration of cartilage and subchondral bone after implanting into the osteochondral defect in rats. In addition, cartilage “tidemarks” completely regenerated after 12 weeks of implantation of the bilayer scaffold, which indicates no tissue disjunctions formed between the regenerated cartilage and subchondral bone.
YAP‐Suppressive Nanodrug Crosslinked Self‐Immunoregulatory Polysaccharide Injectable Hydrogel for Attenuating Cardiac Fibrosis to Treat Myocardial Infarction
Authors: Sun Yage , Zhang Xiaoping , Wu Tengling , Zhang Zhuodan , Yang Rong , Liu Wenguang 
Published: March 2023

AbstractThe cardiac fibrosis caused by excessive deposition of collagen and the fibro‐inflammatory cascade reaction severely impedes the cardiac regenerative efficiency after myocardial infarction (MI) so that the onefold treating target is far from satisfying therapeutic efficacy. Herein, a yes‐associated protein (YAP)‐suppressive nanodrug‐crosslinked self‐immunoregulatory polysaccharide injectable hydrogel is fabricated for the first time. To this end, cationic liposomes loading YAP inhibitor verteporfin (Lipo‐VP) is prepared and coated with oxidized fucoidan (OFu), a unique anti‐inflammation polysaccharide, to form anti‐fibrotic and immunoregulatory nanodrug (OFu‐Lipo‐VP). The coated fucoidan itself acts as a reactive oxygen species (ROS) scavenger and inflammation regulator, thus facilitating angiogenesis function by eliciting endogenous vascular endothelial growth factor secretion of macrophages. Then an injectable hydrogel (termed as OFu‐Lipo‐VP‐PGA) is formed through addition reaction between the aldehyde groups of OFu‐Lipo‐VP and the thiol groups of thiol‐modified poly(γ‐glutamic acid) (PGA‐SH), where the thiol groups can also aid in eliminating ROS. The acute MI models are established and the infarcted male rats are treated with this injectable OFu‐Lipo‐VP‐PGA hydrogel after MI. The outcomes at 28 days post‐surgery indicate efficient restoration of cardiac functions and attenuation of cardiac fibrosis. This study opens up a new possibility for MI treatment with immunoregulatory and antifibrotic injectable polysaccharide‐based hydrogel.
Carbazole‐Based Anion Ionic Water‐Soluble Two‐Photon Initiator for Achieving 3D Hydrogel Structures
Authors: Bin Fan‐Chun , Guo Min , Li Teng , Zheng Yong‐Chao , Dong Xian‐Zi , Liu Jie , Jin Feng , Zheng Mei‐Ling 
Published: March 2023

Abstract3D hydrogel structures fabricated by two‐photon polymerization (TPP) have become attractive in biomedical fields. Generally, conventional organic solvents are toxic and the residues left in the fabricated 3D structures are harmful to cells. Hence, anion ionic carbazole‐based water‐soluble two‐photon initiator (TPI) 3,6‐bis[2‐(1‐methylpyridinium)vinyl]‐9‐methylcarbazole ditosylate (BT) is proposed to construct arbitrary 3D hydrogel structures. Cucurbit[7]uril (CB7) and BT form a host‐guest complex (CB7/BT) with a binding ratio of 1:1, which further improves the water solubility, biocompatibility and nonlinear absorption property of TPI. A water‐soluble photoresist consisting of photoinitiator CB7/BT and monomer poly(ethylene glycol) diacrylate is prepared to explore the TPP fabrication capacity. The electron paramagnetic resonance measurement shows that CB7/BT initiates photopolymerization by alkyl radicals. The laser threshold power of the photoresist is 6.3 mW and the feature size is 127 nm in TPP at 780 nm. The initiator with p‐toluenesulfonate anion exhibits higher binding energy, larger two‐photon absorption cross‐section and two‐photon fabrication resolution compared with the previous work using iodide as an anion, indicating a promising way to improve the fabrication capacity of water‐soluble TPI through changing the anion ionic group. The proposed strategy will provide high potential for the further application in the biomedical field.
Strain‐Sensitive Flexible Magnetoelectric Ceramic Nanocomposites
Authors: Kim Minsoo , Kim Donghoon , Aktas Buse , Choi Hongsoo , Puigmartí‐Luis Josep , Nelson Bradley J. , Pané Salvador , Chen Xiang‐Zhong 
Published: March 2023

AbstractMagnetoelectric (ME) oxide materials can convert magnetic input into electric output and vice versa, making them excellent candidates for advanced sensing, data storage, and communication. However, their application has been limited to rigid devices due to their brittle nature. Here, flexible ME oxide composite (BaTiO3/CoFe2O4) thin film nanostructures with distinct ME coupling coefficients are reported. In contrast to rigid bulk counterparts, these ceramic nanostructures display a flexible behavior after being released from the substrate, and can be transferred onto a stretchable substrate such as polydimethylsiloxane. These ceramic films possess high ME coefficients due to minimized clamping effect and preferred crystalline orientation, and exhibit reversibly tunable ME coupling via mechanical stretching thanks to their large elasticity (>4%). It is believed that the study can open up new avenues for integrating ceramic ME composites into micro‐/nanoelectromechanical system and soft robotic devices.
Effect of physical activity intervention on cognitive function in China: A cluster randomized trial
Authors: Li Nanyan , Deng Qian , Yang Qingyuan , Wang Yufei , Hu Julinling , Zhao Xing , Zhou Junmin 
Published: March 2023

AbstractINTRODUCTIONCurrent randomized trial evidence on the effect of physical activity (PA) intervention on cognitive function is scarce and mainly found in well‐educated populations, limiting its generalizability. Furthermore, the modification effect of education levels remains understudied. We conducted a cluster randomized trial to evaluate the effects of PA intervention on cognitive function in a general older population, and whether education modifies such effects.METHODSEight villages were randomized to the intervention (four villages, n = 240) or the control (four villages, n = 271). The intervention group received an 8‐week multilevel PA intervention based on a socio‐ecological model, while the control did not. The intervention has been condensed to three levels with activities occurring at the individual (telephone counseling, printed material, and training sessions), interpersonal (peer group), and community levels (group sharing and coaching). The primary outcome was changes in global cognition (overall cognitive function) measured by the Telephone Interview for Cognitive Status (TICS‐10) at 12‐month follow‐up. Repeated measurements were modeled using the linear mixed model, which assumed that the missing values were missing at random.RESULTSThe mean age was 70.94 years (standard deviation 5.71) and 55.6% were women. Compared to the control, the orientation improved from baseline at 12‐month follow‐up (0.24 points [95% confidence interval (CI), 0.03 to 0.46 points; P = 0.03]). Stratified analysis showed that the global cognition and orientation improved at 12‐month follow‐up among illiterate participants in the intervention (for global cognition, mean difference, 0.57 points [95% CI, 0.03 to 1.10], P = 0.04; for orientation, mean difference, 0.31 points [95% CI, 0.04 to 0.58], P = 0.03).DISCUSSIONThese results confirm the improvements in orientation in older adults, as well as in global cognition and orientation in the illiterate at 12‐month follow‐up.
The bioelectrical properties of bone tissue
Authors: Heng Boon Chin , Bai Yunyang , Li Xiaochan , Meng Yanze , Lu Yanhui , Zhang Xuehui , Deng Xuliang 
Published: March 2023

AbstractUnderstanding the bioelectrical properties of bone tissue is key to developing new treatment strategies for bone diseases and injuries, as well as improving the design and fabrication of scaffold implants for bone tissue engineering. The bioelectrical properties of bone tissue can be attributed to the interaction of its various cell lineages (osteocyte, osteoblast and osteoclast) with the surrounding extracellular matrix, in the presence of various biomechanical stimuli arising from routine physical activities; and is best described as a combination and overlap of dielectric, piezoelectric, pyroelectric and ferroelectric properties, together with streaming potential and electro‐osmosis. There is close interdependence and interaction of the various electroactive and electrosensitive components of bone tissue, including cell membrane potential, voltage‐gated ion channels, intracellular signaling pathways, and cell surface receptors, together with various matrix components such as collagen, hydroxyapatite, proteoglycans and glycosaminoglycans. It is the remarkably complex web of interactive cross‐talk between the organic and non‐organic components of bone that define its electrophysiological properties, which in turn exerts a profound influence on its metabolism, homeostasis and regeneration in health and disease. This has spurred increasing interest in application of electroactive scaffolds in bone tissue engineering, to recapitulate the natural electrophysiological microenvironment of healthy bone tissue to facilitate bone defect repair.
Auroral oval reconstruction for historical geomagnetic storms in the 18th and 19th century
Authors: Wagner D. , Neuhäuser R. , Arlt R. 
Published: March 2023

AbstractThe investigation of extreme space weather events can yield important information about the solar activity. Here, we present the reconstruction of the auroral oval position and size based on Bayesian inference for nine historical geomagnetic storms between 1716 and 1882, including the Carrington event in 1859, by using ground‐based observations, which enables us to derive the Kp index for historical events for the first time. The results for the latter show a very high level of geomagnetic disturbance (8.2 Kp 8.7, −929 nT Dst −1327 nT). Furthermore, we were able to derive the position of the pole in corrected geomagnetic coordinates, where especially the longitude is in good agreement with the position derived from the gufm1 model (Jackson et al., 2000). For the eight other historical storms, the Kp and Dst indices have been calculated here for the first time. In all cases, a very high Kp index was derived. The only exception is the geomagnetic storm from March 1716, which is, with a Kp index of , comparable with the St. Patrick's Day storm in 2015.
Building blockchain‐driven dynamic capabilities for developing circular supply chain: Rethinking the role of sensing, seizing, and reconfiguring
Authors: Quayson Matthew , Bai Chunguang , Sun Lihua , Sarkis Joseph 
Published: March 2023

AbstractGlobally, firms face increasing pressure to efficiently utilize resources and minimize costs and may do so through sustainable supply chains and circular economy practices. Emerging technologies, such as blockchain, to enable a circular economy have become a new industrial paradigm. However, firms require building dynamic capabilities through blockchain, which can be key to realizing circular economy model. This study introduces a framework for building blockchain‐driven dynamic capabilities for a circular supply chain. We further use the Decision Making Trial and Evaluation Laboratory (DEMATEL) method to evaluate three major dynamic capabilities and 18 sub‐dynamic capabilities and their interrelationships. The mining industry in Ghana sets the stage for this analysis. The study results show that although blockchain‐driven sensing dynamic capability, seizing dynamic capability, and reconfiguring dynamic capability are crucial for developing a circular supply chain, they do not strictly follow a sequence and overlap. We highlight various cause–effect relationships, providing insights into the role of sensing, seizing, and reconfiguring dynamic capabilities. That information is important to firms, stakeholders, and partners to draft an appropriate strategy to build blockchain‐driven dynamic capabilities for developing a circular supply chain.
Electrocatalytic Oxidative Coupling of Methane on NiFe Exsolved Perovskite Anode: Effect of Water
Authors: Kim Jaesung , Ferree Matthew , Gunduz Seval , Millet Jean‐Marc M. , Aouine Mimoun , Co Anne C. , Ozkan Umit S. 
Published: March 2023

AbstractOxidative coupling of methane (OCM) can be performed electrocatalytically by utilizing solid oxide cells, which provide a readily controlled oxygen supply through dense electrolytes. La0.7Sr0.2Ni0.2Fe0.8O3 (LSNF) perovskite is an effective anode for OCM. Its surface characteristics and electrocatalytic activity can be improved by reduction and the resultant exsolution of bimetallic NiFe nanoparticles from its bulk. X‐ray diffraction (XRD) and environmental transmission electron microscopy proved that the evolution of hetero‐phases under reducing environment resulted in bimetallic NiFe nanoparticles being formed on the surface. A 36 % improvement in C2+ hydrocarbon production rate was achieved due to the reduction of LSNF with the exsolved NiFe nanoparticles. Co‐feeding of H2O enhanced selective conversion of CH4 resulting in the production rate of C2+ hydrocarbons being increased by 56 %. Analysis of impedance spectra and in‐situ DRIFTS under a CH4+H2O atmosphere provided an understanding for the enhancement on the electrocatalytic OCM.
Parallel streams of raphe VGLUT3‐positive inputs target the dorsal and ventral hippocampus in each hemisphere
Authors: Fortin‐Houde Justine , Henderson Fiona , Dumas Sylvie , Ducharme Guillaume , Amilhon Bénédicte 
Published: March 2023

AbstractThe hippocampus (HP) receives neurochemically diverse inputs from the raphe nuclei, including glutamatergic axons characterized by the expression of the vesicular glutamate transporter type 3 (VGLUT3). These raphe‐HP VGLUT3 projections have been suggested to play a critical role in HP functions, yet a complete anatomical overview of raphe VGLUT3 projections to the forebrain, and in particular to the HP, is lacking. Using anterograde viral tracing, we describe largely nonoverlapping VGLUT3‐positive projections from the dorsal raphe (DR) and median raphe (MnR) to the forebrain, with the HP receiving inputs from the MnR. A limited subset of forebrain regions such as the amygdaloid complex, claustrum, and hypothalamus receives projections from both the DR and MnR that remain largely segregated. This highly complementary anatomical pattern suggests contrasting roles for DR and MnR VGLUT3 neurons. To further analyze the topography of VGLUT3 raphe projections to the HP, we used retrograde tracing and found that HP‐projecting VGLUT3‐positive neurons (VGLUT3HP) distribute over several raphe subregions (including the MnR, paramedian raphe, and B9 cell group) and lack co‐expression of serotonergic markers. Strikingly, double retrograde tracing experiments unraveled two parallel streams of VGLUT3‐positive projections targeting the dorsal and ventral poles of the HP. These results demonstrate highly organized and segregated VGLUT3‐positive projections to the HP, suggesting independent modulation of HP functions such as spatial memory and emotion‐related behavior.
Study on the influence of water injection pressure on water absorption process and water injection effect of coal
Authors: Wang Lin , Chen Xiangjun , Wang Dezhang , An Fenghua 
Published: March 2023

AbstractRock burst disasters can be reduced and prevented with the help of coal dust water injection. In this study, the high‐pressure water injection device is used to examine how the water absorption rate changes over time under various water injection pressures. The results reveal that the water absorption rate of coal samples increases quickly initially before slowing down with water absorption time. Its change can be described using the Langmuir equation. In addition, the Langmuir equation is utilized to demonstrate how water injection pressure affects the maximum water absorption of coal samples. The effects of experimental findings and numerical analysis are investigated on water injection pressure. The breadth and extent of coal bodies with increased moisture are continuously expanding at the same water injection pressure and water injection time. The water absorption of coal close to the borehole remains relatively unchanged with an increase in water injection pressure, but the water absorption range of coal in the vicinity increases. Therefore, raising the water injection pressure and duration will improve the effective range of water injection. © 2023 Society of Chemical Industry and John Wiley & Sons, Ltd.
Projections of hippocampal CA2 pyramidal neurons: Distinct innervation patterns of CA2 compared to CA3 in rodents
Authors: Shinohara Yoshiaki , Kohara Keigo 
Published: March 2023

AbstractThe hippocampus is a center for spatial and episodic memory formation in rodents. Understanding the composition of subregions and circuitry maps of the hippocampus is essential for elucidating the mechanism of memory formation and recall. For decades, the trisynaptic circuit (entorhinal cortex layer II—dentate gyrus — CA3—CA1) has been considered the neural network substrate responsible for learning and memory. Recently, CA2 has emerged as an important area in the hippocampal circuitry, with distinct functions from those of CA3. In this article, we review the historical definition of the hippocampal area CA2 and the differential projection patterns between CA2 and CA3 pyramidal neurons. We provide a concise and comprehensive map of CA2 outputs by comparing (1) ipsi versus contra projections, (2) septal versus temporal projections, and (3) lamellar structures of CA2 and CA3 pyramidal neurons.
A systematic review to identify the challenges to achieving effective patient flow in public hospitals
Authors: Manning Larissa , Islam Md. Shahidul 
Published: March 2023

AbstractThis systematic review aims to uncover the challenges related to patient flow from a whole public hospital perspective and identify strategies to overcome these challenges. A search in Medline, Emcare and PubMed was conducted and 24 articles published in English, from 2015 to 2020, were selected in relation to patient flow challenges and strategies. Analysis of the articles was completed using a thematic approach to identify common themes in relation to the area of focus. Strategies from the literature were then aligned with the challenges to inform areas of potential improvement in relation to patient flow. The themes generated included Teamwork, Collaboration and Communication; Public Hospitals as complex systems; Timely discharge; Policy, Process and Decision‐making; and Resources‐capacity and demand. The key finding is that a whole system approach is required to improve patient flow in public hospitals. When effective patient flow is achieved, demand and capacity are matched, increasing patient access to the health service and enabling the resources required to provide high quality patient care. The findings will create a better understanding of improving patient flow in public hospitals.
Long‐term and seasonal variation of open‐surface water bodies in the Yellow River Basin during 1990–2020
Authors: Jiao Chentai , Wang Shuai , Song Shuang , Fu Bojie 
Published: March 2023

AbstractOpen‐surface water bodies are essential terrestrial water sources and ecosystem service providers, and their evaluation is necessary for effective water management. In this study, 36 000 Landsat images of the Yellow River Basin (YRB) were collected, and a multiple index (Modified Normalized Difference Water Index, Normalized Difference Vegetation Index and Enhanced Vegetation Index, i.e. MNDWI, NDVI and EVI) method was used to identify open‐surface water bodies in the flood and dry seasons during 1990–2020. Our results showed that during these 30 years, YRB surface waters were characterized by spatial and seasonal heterogeneities. The open‐surface water coverage in the upper and middle reaches of the YRB was 8.74‰ and 4.24‰, respectively, less than the average coverage in the whole YRB of 9.45‰. Surface water area was significant larger in flood seasons than in dry seasons, while during 1990–2020, the surface water area increased by 27.5% in the flood season and by 58.9% in the dry season, reaching 7239.2 km2 (flood season) and 6654.8 km2 (dry season) in 2020. Meanwhile the seasonal variation has decreased. Climate factors (winter temperature and summer precipitation) positively correlated with open‐surface water only in the source region of the YRB. In other regions, anthropic factors (e.g. water conservation projects) strongly affected open‐surface water bodies by increasing their spatial area overall and decreasing seasonal differences in their coverage.
Self‐report measure of parental reflective functioning: A study of reliability and validity across three samples of varying clinical risk
Authors: Carlone Christina , Milan Stephanie , Decoste Cindy , Borelli Jessica L. , McMahon Thomas J. , Suchman Nancy E. 
Published: March 2023

AbstractThe Parental Reflective Functioning Questionnaire (PRFQ) provides an efficient way to measure a parent's capacity to recognize their child's mental states and to understand the relationship between underlying mental states and behavior. To date, limited work evaluates its psychometric properties beyond initial validation studies. Here we examined the reliability and validity of the PRFQ in three samples of varying clinical risk (e.g., community sample, previous mental health diagnosis, substance use disorder diagnosis). Across samples, the majority (e.g., 75%–78%) of mothers identified as White; all mothers were from the USA. We compared the PRFQ to task‐based measures of mentalization, the Parent Development Interview (PDI), and measures of the parent‐child relationship. The PRFQ was a reliable measure across samples, and it was associated in theoretically consistent ways with task‐based measures of mentalization. Parental RF across the PDI and PRFQ were not highly correlated in a sample of mothers with substance use disorders. Existing RF measures may be tapping into a different component of the broader construct of parental reflective functioning (PRF). The PRFQ was further validated by demonstrating relationships with parent‐report measures of the parent‐child relationship. Taken together, these findings provide additional support for the reliability and validity of the PRFQ.