bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Numerical Study of the Effect of Magnetic field in the Entrance region of a Couette flow in a Duct Filled with Porous Material under the Local Thermal Non-Equilibrium
Authors: Bhargavi D. , Gupta Nitish , Narayana P. A. Lakshmi 
Published: March 2023

Abstract
The effect of the magnetic field on Couette flow in a porous-filled duct under local thermal non-equilibrium (LTNE) is examined in the present analysis. The bottom plate is moving and experiencing isoflux boundary conditions, whereas the top plate is stationary and adiabatic. The porous region's unidirectional flow fits the Darcy Brinkman (DB) model. The investigations further quantify the impact of the thermal conductivity ratio (κ), Hartmann number (MH), and Biot number (BiH), on heat transfer enhancement. For the coupled energy equations, a successive accelerated replacement (SAR) method is used to generate numerical solutions. The present investigation gives the temperatures in the solid and, the fluid phases in dimensionless form, dimensionless temperature based on the bulk mean temperature and, the local Nusselt number profiles. In the Couette flow model, the magnetic field influences the temperature field in both phases. Additionally, for each Hartmann number, the temperature of the solid phase is greater than that of the fluid phase, validating LTNE. For the thermal field, the fully developed condition is validated in the LTNE model. This study is primarily concerned with modeling high-performance matrix heat exchangers.
Identification of Immune Microenvironment Changes, Immune-Related Pathways and Genes in Male Androgenetic Alopecia
Authors: Xiong Hongdi , Tang Lulu , Chen Haiju , Wu Yi , Li Wenyu , Wen Sijian , Lin Youkun 
Published: March 2023

Abstract
Although Androgenetic Alopecia (AGA) is classified as a non-inflammatory alopecia, histological evidence of microinflammation has long been recognized. However, the changes in the immune microenvironment, the immune-related pathway and the expression of Immune-related genes (IRGs) involved in AGA remain unclear. The microarray gene expression data (GSE36169) from patients with male AGA were analyzed. Gene Set Enrichment Analysis (GSEA) among statistically changed genes was done. KEGG and GO analyses among differentially expressed genes (DEGs) were performed. DEGs were screened to identify IRGs based on the ImmPort database. The cytohubba-MCC plugin of Cytoscape was applied to screen hub immune genes. The infiltration levels of 28 immune cells were quantified adopting single-sample GSEA (ssGSEA) algorithm. The microarray gene expression data (GSE90594) of male AGA was analyzed to validate hub IRGs genes and differential infiltrated immune cells. The ssGSEA revealed γδT cell, central memory CD8+ T cell, mast cell, immature B cell, activated CD8+ T cell, effector memory CD4+ T cell, eosinophil and neutrophil were significantly increased infiltration in the bald scalp. GSEA showed statistically changed genes were most enriched in immune related pathways, including innate immune system, adaptive immune system, cytokine signaling, interferon-γ signaling, interferon signaling and interleukins signaling. The four hub IRGs, including MMP9, PTPRC, BMP2 and THBS1, were enriched in the pathways of allograft rejection, coagulation and interferon-γ response. In summary, we proposed that the increase in γδ T cells, central memory CD8+ T cells, activated CD8+ T cell as well as the infiltration of mast cells contributed to immune microenvironment changes in male AGA. The 4 hub IRGs may be involved in the development and progression of hair loss in male AGA through interferon-γ signal pathways.
A random 2D walk of a submerged free-floating disc in a convective layer
Authors: Frick Peter , Popova Elena , Sukhanovskii Andrei , Vasiliev Andrei 
Published: March 2023

Abstract

Free motions of a thermally insulating disc submerged in a liquid layer heated from below are studied experimentally. The disc is fixed at a certain height from the bottom of the convective cell, but can move freely in horizontal directions. Blocking of vertical motion and heat flux leads to the appearance of large-scale vortices, which in turn, drags the disk. The interplay of the large-scale circulation and the disk produces complex two-dimensional disk motions. The disc dynamics is mainly determined by large-scale modes: toroidal vortex with descending fluid in the center and large-scale vortices along each coordinate, existing on the background of intense, but relatively short-lived small-scale convective cells. The wandering disk forms a cold spot above itself, which affects large-scale circulation but has little effect on cell convection at scales on the order of the layer thickness, which provide the main heat transport and dominate the upper part of the layer. Despite the essentially three-dimensional flow structure, which is fundamentally different from that of the convective flow in an elongated tank with one-dimensional disk motions, the travels along each coordinate look similar to one-dimensional motions.
Deformation failure characteristics and control measures of a shallow loess tunnel in water-rich strata
Authors: Lei Hao , Tang Kunjie , Zhao Kai , Liu Yuhang , Liu Tong 
Published: March 2023

Abstract
With the acceleration of tunnel construction, it is inevitable to cross the collapsible loess region. The engineering properties of loess are very poor in the water-rich environment. Additionally, if the buried depth is shallow, the load bearing capacity is further weakened, which can increase the difficulty of tunnel construction. Therefore, this paper provides a case study on the Pangwan Tunnel based on a geological survey, numerical simulation, and on-site monitoring. The failure characteristics of the studied area under the original support scheme are analyzed in detail, and the extreme deformation mechanism is discussed combining the geological conditions and surrounding rock properties. The results show that there are five main reasons resulting in the extreme deformation of the Pangwan Tunnel, which are: abundant groundwater, low strength of surrounding rock, disintegration of loess after water immersion, depth of tunnel is shallow, and unreasonable original support scheme with low bearing capacity. Then, the corresponding countermeasures are proposed, which are advance drainage, large arch foot and foot-lock bolt, sealing tunnel face and grouting timely, as well as advance pipe shed and small pipe grouting. Finally, from the feedbacks of numerical analysis and field application results, extreme deformation of the Pangwan Tunnel is effectively controlled. This work can provide some helpful guidance for similar projects.
Topical hydrogen peroxide solution 40%in the treatment of genital warts
Authors: Mohamed Hassan Abou Khodair , Aboelwafa Hany Othman , Saleh Fatma Hassan 
Published: March 2023

Abstract
Background; The visible result of a human papillomavirus (HPV) infection caused by one or more of the roughly 100 known strains is genital warts. The most prevalent STD in the world is HPV, and infections with it are strongly linked to major morbidity and death. Numerous malignancies and lesions of the mucosa and epithelium are caused by HPV. Women under the age of 25 are most typically affected by HPV infections,
Aim and objectives; to evaluate the efficacy and safety of topical hydrogen peroxide solution 40% in treatment of genital warts,
Subjects and methods; this study was a randomized controlled trial that was conducted on 52 patients attending the Dermatology outpatient clinic at Damietta Faculty of Medicine, Al-Azhar University. The selected subjects were divided into 26 patients treated with topical H2O2 as Hydrogen peroxide group and 26 patients treated with saline as control group.
Result; There is statistically significant positive correlation between Size of wart after ttt and number of wart after ttt. There is statistically significant reduction in the number of warts with decrease its number after ttt. However, there is no statistically significant correlation between the size and number of warts after ttt with other clinical variables,
Conclusion; One possible course of therapy for genital warts may be hydrogen peroxide solution, particularly the 40% concentration. As a novel topical therapy for genital warts, it is very efficient, secure, affordable, and simple to apply,
Measurement of Shear Strength of Unsaturated Gypseous Soil with Different Degrees of Saturation by Triaxial Test
Authors: Abood Ahmed , Fattah Mohammed , Al-Adili Aqeel 
Published: March 2023

AbstractThe purpose of the present work is to assess the suitability of unsaturated gypseous soil as subgrade layer for carrying machines foundations. An extensive laboratory testing program was carried out to study the geotechnical properties and the behavior of unsaturated gypseous soil. Gypseous soil samples were brought from a region in Tikrit city in Salah Al-Dean governorate, north of Baghdad. The tests include physical tests such as moisture content, specific gravity, classification tests, relative density, compaction's Proctor, and consolidated undrained triaxial test. Chemical tests were also carried out. The specimen was prepared by using vacuum pump and suction operation (the value of the suction operation ranges -20 kPa approximately), where this method using to the granular soil suction operation such as sandy gypseous soil to pull void air spaces out of the soil until the soil grains of holds together. Therefore, once the sample former is removed the suction will stop the sample from collapsing. Then, triaxial test was carried out on the gypseous soil. The tests were performed for samples at 35% relative of density for the natural, unsaturated, and fully saturated gypseous soil at degrees of saturation (30%, 60%, and 80%). It was found that increasing the moisture of the gypseous soil at all degrees of saturation causes a decrease in the angle of internal friction for both the total and effective stresses (ϕ, and ϕ'), where the decrease ranged between (25.5° - 5.0°) in relation to the total stresses, and (27.5° - 5.5°) in relation to the effective stresses. While the soil cohesion for both of the total and effective stresses (c, and c') increased with the increase of gypseous soil moisture up to the saturation degree (60%), this leads to an increase in shear strength of the soils. Then a gradual decrease was observed at the saturation degrees (80%, and 100%), respectively. Thus, this leads to a decrease in shear strength of the soil, which ranged from (12.5 - 9.5) kPa for the total stresses, and between (11.5 - 9.0) kPa for the effective stresses, respectively.
Kinome-wide synthetic lethal screen identifies PANK4 as modulator of resistance in glioblastoma
Authors: Vella Viviana , Ditsiou Angeliki , Chalari Anna , Eravci Murat , Wooler Sarah K , Gagliano Teresa , Bani Cecilia , Kerschbamer Emanuela , Pearl Frances M.G. , Lopez Gianluca , Peng Ling , Stebbing Justin , Klinakis Apostolos , Giamas Georgios , Xu Bin , Zhang Yongchang 
Published: March 2023

Abstract
Temozolomide (TMZ) represents the cornerstone of therapy for glioblastoma (GBM). However, acquisition of resistance limits its therapeutic potential and therefore poses the need to identify new therapeutic combinations that could improve treatment outcomes. Despite the human kinome has proved to be an undisputable source of druggable targets, our knowledge remains confined to a limited fraction of it, with a multitude of under-investigated proteins yet to be characterised. Using a kinome-wide RNAi screen, we found that abrogation of pantothenate kinase 4 (PANK4) enhances the antiproliferative effects of TMZ in GBM in vitro. Further validation of our top-hit across various TMZ-resistant GBM cell models, patient-derived GBM cell lines and tissue samples, as well as in vivo studies, corroborated the potential translational significance of our findings. We showed that PANK4 expression is induced during TMZ treatment, and its expression is associated with a worse clinical outcome. Using a Tandem Mass Tag (TMT)-based quantitative proteomic approach, a comprehensive global protein dynamics analysis was undertaken to identify key response signatures upon PANK4 knockdown, in the presence or absence of TMZ. We revealed that silencing of PANK4 leads to a marked downregulation of a subset of proteins involved in cellular detoxification. More specifically, as cells undergo genotoxic stress during TMZ exposure, PANK4 depletion represents a synthetic vulnerability, focal point that can lead to critical cellular damage, accumulation of toxic metabolites, and subsequent cell death. Taken together, we unveil a previously unreported role for PANK4 in mediating therapeutic resistance to TMZ in GBM.
CORRELATION BETWEEN FOOTWEAR SUITABILITY, FEAR OF FALLING AND PHYSICAL ACTIVITY IN THE THIRD TRIMESTER
Authors: KEPENEK VAROL Büşra , ODABAŞI Didar , DOĞAN Birsen Ezgi , GÜLENER Gülsüm , SELÇUK Ayşenur , YAZICI-GÜLAY Meltem , AKSOY Hüseyin 
Published: March 2023

Purpose: Pregnancy is a time in which the biomechanics of the body changes due to intense physiological and physical changes, especially in the third trimester, when an increase in falls and a decrease in physical activity may occur. The aim of this study is to investigate the relationship between the suitability of footwear used by pregnant women, fear of falling, and physical activity in third trimester of pregnancy.
Methods: One hundred twenty-three pregnant women aged between 18-40 years with a gestational age of 28 weeks and above were included the study. The Footwear Assessment Score was used to assess the suitability of the footwear. The fear of falling of the participants was measured using the Falls Efficacy Scale-International, and the physical activity level was measured using the short form of the International Physical Activity Questionnaire.
Results: A low negative correlation (r=-0.215;p
Improved monthly runoff time series prediction using the SOA–SVM model based on ICEEMDAN–WD decomposition
Authors: Xu Dong-mei , Wang Xiang , Wang Wen-chuan , Chau Kwok-wing , Zang Hong-fei 
Published: March 2023

Abstract
In runoff prediction, the prediction accuracy is often affected by the non-linear and non-stationary characteristics of the runoff series. In this study, a coupled forecasting model is proposed that decomposes the original runoff series by an improved complete ensemble Empirical Mode Decomposition (EMD) (ICEEMDAN) combined with a wavelet decomposition (WD) and then forecasts the monthly runoff using a support vector machine (SVM) optimized by the seagull optimization algorithm (SOA). In this method, a series of Intrinsic Mode Function (IMF) and a Residual (Res) are obtained by decomposing the original runoff series with ICEEMDAN. The WD method is used to perform quadratic decomposition of high-frequency components decomposed by the ICEEMDAN method to make the runoff series as smooth as possible. Then the decomposed components are input into the SOA-SVM model for prediction. Finally, the prediction results of each component are superimposed and reconstructed to obtain the final monthly runoff prediction results. RMSE, Mean Absolute Percentage Error (MAPE), Nash-Sutcliffe Efficiency Coefficient (NSEC), and R are selected to evaluate the prediction results and the model is compared with SOA-SVM model, EMD-SOA-SVM model and CEEMDAN-SOA-SVM model other models. The proposed model is applied to the monthly runoff forecast of the Hongjiadu and Manwan Reservoirs. When compared with other benchmarking models, the ICEEMDAN-WD-SOA-SVM model attains the smallest Root Mean Square Error (RMSE) and MAPE and the largest NSEC and R. The ICEEMDAN-WD-SOA-SVM model has the best prediction effect, the highest prediction accuracy, and the lowest prediction error.
Synthesis of activated carbon from banana peels for dye removal of an aqueous solution in textile industries: optimization, kinetics, and isotherm aspects
Authors: Nadew Talbachew Tadesse , Keana Mestawot , Sisay Tsegaye , Getye Belay , Habtu Nigus Gabbiye 
Published: March 2023

Abstract
Treatment of harmful chemicals using materials at our disposal is the way forward. This study activated bio-adsorbent from waste banana for dye removal from an aqueous solution. The banana peel was activated both thermally and chemically with a preliminary study of a 0.5−2.5 M sulfuric acid concentration, and 50−90 °C of temperature for 1−5 h activation time. Activation at 1.5 M acid concentration, 70 °C for 3 h showed a promising efficacy of about 90% of removing dye. Activated banana peel was characterized using proximate analysis, BET, TGA, SEM, XRD, and FTIR. BET results showed activated banana peel to be porous material with a surface area of 432 m2/g. The adsorption capacity of the adsorbent with different variables range (adsorption time 20−140 min, pH 1.0−7.0, adsorbent dose 1−4 g/L and initial dye concentration 20−80 mg/L) was tested based on a preliminary study. The adsorption process was optimized numerically and the results were; adsorption time 60 min, pH 3, adsorbent dose 2 g/L and initial dye concentration 40 mg/L. The pseudo-second-order kinetics model and Langmuir isotherm model were the best fit to describe the adsorption process.
Occurrence and risk assessment of PAHs from athletic fields under typical rainfall events
Authors: Zhang Xiaoran , Gu Yuyang , Wang Yinrui , Liu Junfeng , Jiang Yucheng , Tian Yiran , Zhang Ziyang , Tan Chaohong , Wang Yu , Li Haiyan , Hu Yuansheng 
Published: March 2023

Abstract

Six polycyclic aromatic hydrocarbons (PAHs) including naphthalene (Nap), fluorene (Flu), phenanthrene (Phe), fluoranthene (Fla), pyrene (Pyr), and chrysene (Chr) were detected in runoff from five athletic fields during three rainfall events. The event mean concentration (EMC) of ∑6PAHs ranged from 3.96 to 23.23 μg/L, which was much higher than the EMC in urban traffic area runoff. Except for Nap, the PAH concentrations followed in the order of artificial turf &gt; badminton court &gt; basketball court &gt; plastic runway &gt; optennis court. The surface characteristics of the athletic fields, such as the composition of materials and roughness, played an essential role in the release of PAHs. ∑6PAHs concentration during the 2nd rainfall event (July 22nd) was the highest among the three rainfall events, indicating that high rainfall intensity facilitated the PAHs release. PAHs during three rainfall events showed little first flush effect except for the artificial turf during the 2nd (22nd July) and 3rd (29th July) rainfall events. The first flush effect could be affected by rainfall characters, PAH properties, and surface characteristics of athletic fields. Ecological risk assessment showed that PAHs in runoff corresponded to moderate-to-high risk, while health risk assessment showed that PAHs could pose a potential carcinogenic danger to human health via dermal contact.
Physicochemical Characterization of Silver Sulfadiazine in Polymeric Wound
Dressings
Authors: de Melo Demis Ferreira , Guedes Gabryella Garcia , de Carvalho Moreira Lívia Maria Coelho , Oshiro-Júnior João Augusto , de Lima Damasceno Bolívar Ponciano Goulart 
Published: March 2023

Abstract:
The insertion of topical antimicrobials in wound treatment represented an important role in patient
management. Among these agents, silver sulfadiazine (AgSD), introduced in the therapy of wounds and burns
in the 1960s, is considered the gold standard in treatment due to its mechanism of action, in addition to its proven
efficacy and safety. The association of AgSD with polymers for the development of curative formulations
has been reported. The evaluation of the physical-chemical properties of these systems with the aid of analytical
techniques of characterization is essential for the determination of their activities, besides allowing the detection
of possible incompatibilities between AgSD and polymers. Thus, this review presents the main techniques of
physicochemical characterization used in the evaluation of systems containing AgSD with curative purposes in
order to provide parameters to ensure the efficacy and safety of these new therapeutic options. Microscopic,
thermoanalytical, and spectroscopic techniques, for example, provide information on system properties such as
surface chemical composition, crystallinity, morphology, and thermal stability of curative formulations containing
AgSD. These techniques are important in the selection of the most appropriate techniques during the development
of a polymeric curative system containing AgSD, in addition to providing information for cost reduction
of a possible scale-up and the establishment of methodologies for quality control of these systems to ensure
their efficacy and safety.
Significance of Vitamin Supplementation in Reducing the Severity of
COVID-19
Authors: Aiges Myia , Ramana Kota V. 
Published: March 2023

Abstract:
Coronavirus disease-19 (COVID-19), a serious pandemic due to the SARS-CoV-2 virus
infection, caused significant lockdowns, healthcare shortages, and deaths worldwide. The infection
leads to an uncontrolled systemic inflammatory response causing severe respiratory distress and
multiple-organ failure. Quick development of several vaccines efficiently controlled the spread of
COVID-19. However, the rise of various new subvariants of COVID-19 demonstrated some concerns
over the efficacy of existing vaccines. Currently, better vaccines to control these variants are
still under development as several new subvariants of COVID-19, such as omicron BA-4, BA-5, and
BF-7 are still impacting the world. Few antiviral treatments have been shown to control COVID-19
symptoms. Further, control of COVID-19 symptoms has been explored with many natural and synthetic
adjuvant compounds in hopes of treating the deadly and contagious disease. Vitamins have
been shown to modulate the immune system, function as antioxidants, and reduce the inflammatory
response. Recent studies have investigated the potential role of vitamins, specifically vitamins A, B,
C, D, and E, in reducing the immune and inflammatory responses and severity of the complication.
In this brief article, we discussed our current understanding of the role of vitamins in controlling
COVID-19 symptoms and their potential use as adjuvant therapy.
Elevation of LEM Domain Containing 1 Predicts Poor
Prognosis of NSCLC Patients and Triggers Malignant Stemness
and Invasion of NSCLC Cells by Stimulating PI3K/AKT Pathway
Authors: Li Li , Zhang Pei 
Published: March 2023

Background:
Non-small cell lung cancer (NSCLC) is a leading cause of
cancer-related death globally. LEM domain containing 1 (LEMD1) function has been
identified in several cancers but not in NSCLC.

Objective:
This study aimed to investigate the LEMD1 function in NSCLC.

Methods:
NSCLC tissues were obtained from 66 patients, and LEMD1 expressions
were measured using quantitative real-time PCR, immunohistochemical assay, and
Western blot. Overall survival of NSCLC patients was estimated by the Kaplan-Meier
method. Meanwhile, LEMD1 function and mechanism were assessed using Cell Counting
Kit-8, 5-Ethynyl-2′-deoxyuridine analysis, Transwell, Sphere formation assay, and
flow cytometry. Furthermore, LEMD1 function in vivo was evaluated by establishing a
xenograft tumor model, hematoxylin-eosin staining, and immunohistochemical assay.

Results:
LEMD1 was highly expressed in NSCLC tissues and was interrelated to tumor
differentiation, TNM stage, and lymph node metastasis of patients. Overall survival
of NSCLC patients with high LEMD1 was found to be lower than that of patients
with low LEMD1. Functionally, interference with LEMD1 restrained NSCLC cell proliferation,
invasion, and stemness characteristics. Mechanistically, LEMD1 facilitated the
malignant phenotype of NSCLC, and 740 Y-P reversed this impact, prompting that
LEMD1 aggravated NSCLC by activating PI3K/AKT pathway. Furthermore, LEMD1
knockdown hindered NSCLC proliferation in vivo.

Conclusion:
LEMD1 accelerated NSCLC cell proliferation, invasion, and stemness
characteristics via activating PI3K/AKT pathway.