bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transplante de pâncreas e rim simultâneo com enxerto renal proveniente de doador vivo
Authors: Caravatto Pedro Paulo de Paris , Dumarco Rodrigo Blanco , Rocha Paulo Gouveia , Miranda Marcelo Perosa de , Miranda Marcelo Perosa de , Genzini Tércio , Gullo Neto Salvador 
Published: March 2023

O transplante de pâncreas e rim simultâneo (TPRS) assumiu na última década, importante papel no tratamento dos pacientes diabéticos insulino-dependentes com doença renal em fase terminal. A melhora nos resultados obtidos com esta terapia tornou a indicação deste procedimento mais freqüente, acarretando aumento na lista de receptores e, consequentemente, maior tempo de espera pelo transplante. Com o intuito de reduzir o tempo de espera em lista e associar os benefícios imunológicos e técnicos do transplante realizado com doador-vivo relacionado, alguns centros mundiais passaram a indicar o TPRS com o emprego de enxerto renal proveniente de doador-vivo relacionado. Apresentamos a seguir, o primeiro caso realizado no país desta modalidade de transplante de pâncreas.
Análise da preservação do miocárdio após administração de N-2 mercaptopropionilglicina em modelo experimental de isquemia e reperfusão em cães
Authors: Ketzer Bernardo Mazzini , Feldman Andre , Grabarz Rony , Abuhab Abrão , Gun Carlos , Luca Fabio Augusto de , Abdo Emílio 
Published: March 2023

As doenças cardiovasculares representam a principal causa de morbi-mortalidade da atualidade, sendo a doença arterial coronariana seu maior expoente. Novos conhecimentosfisiopatológicos indicam outros mecanismos para injúria miocárdica, ainda pouco estudados. O objetivo desse trabalho é analisar o efeito da N2-Mercaptopropionilglicina (N2-MPG) como agente protetor do miocárdio durante a isquemia/reperfusão, com base na preservação da área denecrose. Foram utilizados 16 cães alocados em dois grupos de oito cães cada: Grupo I (N2-MPG) e Grupo II (controle). Após a reprodução experimental de infarto agudo do miocárdio, os corações foram corados (TTC/Azul de Evans) e pesados para análise da preservação do miocárdio. Os resultados, em relação à preservação da área de necrose, foram: Grupo I (73,14%) e Grupo II (49,98%) através do método de Mann-Whitney. A redução da área de necrose obtida neste estudo apresentou diferença estatística significativa entre os grupos mostrando uma reduçãomédia de 23,16%, concluindo-se que a N2-MPG possui efeito protetor durante a isquemia/reperfusão do miocárdio.
Breve história da estereotaxia
Authors: Teixeira Manoel Jacobsen , Fonoff Erich 
Published: March 2023

Este é um artigo ilustrativo sobre o desenvolvimento dos aparelhos estereotáxicos desde os modelos aplicados a pesquisa anatômicas em animais até os dias de hoje. Houveuma evolução extraordinária com simplificação dos aparelhos para aumentar a praticidade dos procedimentos, no entanto manteve-se o conceito inicial da localização milimétricatridimensional no encéfalo. Os referenciais deixaram de ser as proeminências ósseas cranianas e passaram a ser estruturas encefálicas que podiam ser correlacionadas aos atlas encefálicos, aumentando a precisão dos procedimentos. Atualmente técnicas de neuroimagem como a tomografia computadorizada ou a ressonância magnética trazem características tridimensionais do encéfalo de cada indivíduo e podem ser fundidas aos atlas conformacionais com auxílio da computação gráfica, aumentando a segurança e a melhoria dos resultados de forma menos invasiva.
Ontogenetic changes in sagitta otoliths of whitemouth croaker Micropogonias furnieri (Acanthuriformes: Sciaenidae) and its implication in acoustic communication
Authors: Verocai José E. , Lombarte Antoni , Norbis Walter 
Published: March 2023

Abstract
The otoliths of teleosts are part of the inner ear. They are related to the balance system and are also mechanical components of sound transmission, responsible for hearing in fish. Their morphology is determined by the function they perform and is also influenced by environmental factors. In this context, our goal was to: analyse the possible morphological changes of sagitta otoliths of Micropogonias furnieri (Desmarest, 1823) during its ontogeny, based on six biometric indexes. We analysed 162 sagittae otoliths of Micropogonias furnieri collected in the Rio de la Plata estuary. The variation of the indexes was associated with the different size groups. Rectangularity and aspect ratio [otolith length/total fish length (OL/TL) and sulcus area/otolith area (SA/OA)] were the indexes that contributed the most to the discriminant function. Biometric index differences were related to diverse juvenile environments. The observed shift in the SA/OA relationship could be attributable to a need to respond to a change in the perception of sound (pulse and frequency) experienced by individuals larger than 20 cm that begin to frequent the same areas as spawning adults. In this sense, the ontogenetic morphological change of sagitta otoliths plays an important role in perception and acoustic communication for this species.
Do academic students overestimate marine litter pollution? A threat analysis using plover birds as a target in a Mediterranean site
Authors: Giovacchini Pietro , Russo Roberta , Anselmi Giuseppe , Battisti Corrado , Marsili Letizia 
Published: March 2023

Abstract
Marine litter is known to pose a threat to biodiversity. In this work, we wanted to verify if marine litter was overestimated as a threat by academic students when compared to other threats acting on a specific conservation target, a coastal bird of conservation concern, breeding on Mediterranean coastal dunes (Kentish Plover, Charadrius alexandrinus) in a site of central Italy (Maremma Regional Park, Tuscany). To test this hypothesis, before conducting any direct local survey (a priori), a panel of academic students in Ecotoxicology and Environmental Sustainability (Second cycle degree; Siena University) collected indirect information on a set of threats (trampling, coastal erosion, marine litter, presence of dogs and illegal plant collection), known as impacting on the target, assigning a score (from 1: low to 4: high) to two selected threat regime attributes (extent and intensity), and obtaining a magnitude score based the judgment only on general information communicated by park operators. After a field survey on the plover’s breeding site, students were newly assigned a posteriori scores (‘after’ phase). The before-after comparison showed that no threat showed a significant difference in scores, except for marine litter, which was significantly a priori overestimated. Although marine litter is known to threatened plover birds, it has been significantly overestimated at the local level suggesting a prejudice in student evaluation. This biased overestimation could be due to the high media exposure of the marine litter as a threat, making it charismatic, affecting the a priori judgment.
Russian Translations of Foreign Military Books in the 17th Century
Authors: Rusakovskiy Oleg 
Published: March 2023

Abstract
The article explores the role of military treatises and manuals as objects and factors in cultural and technology transfer from Western Europe to Russia in the 17th century in a comparative perspective. Listing the treatises on military tactics, organization and technology, translated for the needs of the Russian monarchs before the radical Westernizing reforms under Tsar Peter I started in 1700, the article analyses how these texts were perceived by their Russian readers and how they might have contributed to the military change in Eastern Europe. It defines the Russian military culture of the age as an elite culture, centred around the ruler’s person. The article also contextualizes the history of translated military books within knowledge transfer, in particular the transfer of Early Modern scientific ideas in Russia, as these books provided an attractive insight into European science and technology, not available for the Russian elite from other sources.
mHealth intervention delivered in general practice to increase physical activity and reduce sedentary behaviour of patients with prediabetes and type 2 diabetes (ENERGISED): rationale and study protocol for a pragmatic randomised controlled trial
Authors: Vetrovsky Tomas , Kral Norbert , Pfeiferova Marketa , Kuhnova Jitka , Novak Jan , Wahlich Charlotte , Jaklova Andrea , Jurkova Katerina , Janek Michael , Omcirk Dan , Capek Vaclav , Maes Iris , Steffl Michal , Ussher Michael , Tufano James J. , Elavsky Steriani , Van Dyck Delfien , Cimler Richard , Yates Tom , Harris Tess , Seifert Bohumil 
Published: March 2023

Abstract
Background
The growing number of patients with type 2 diabetes and prediabetes is a major public health concern. Physical activity is a cornerstone of diabetes management and may prevent its onset in prediabetes patients. Despite this, many patients with (pre)diabetes remain physically inactive. Primary care physicians are well-situated to deliver interventions to increase their patients' physical activity levels. However, effective and sustainable physical activity interventions for (pre)diabetes patients that can be translated into routine primary care are lacking.

Methods
We describe the rationale and protocol for a 12-month pragmatic, multicentre, randomised, controlled trial assessing the effectiveness of an mHealth intervention delivered in general practice to increase physical activity and reduce sedentary behaviour of patients with prediabetes and type 2 diabetes (ENERGISED). Twenty-one general practices will recruit 340 patients with (pre)diabetes during routine health check-ups. Patients allocated to the active control arm will receive a Fitbit activity tracker to self-monitor their daily steps and try to achieve the recommended step goal. Patients allocated to the intervention arm will additionally receive the mHealth intervention, including the delivery of several text messages per week, with some of them delivered just in time, based on data continuously collected by the Fitbit tracker. The trial consists of two phases, each lasting six months: the lead-in phase, when the mHealth intervention will be supported with human phone counselling, and the maintenance phase, when the intervention will be fully automated. The primary outcome, average ambulatory activity (steps/day) measured by a wrist-worn accelerometer, will be assessed at the end of the maintenance phase at 12 months.

Discussion
The trial has several strengths, such as the choice of active control to isolate the net effect of the intervention beyond simple self-monitoring with an activity tracker, broad eligibility criteria allowing for the inclusion of patients without a smartphone, procedures to minimise selection bias, and involvement of a relatively large number of general practices. These design choices contribute to the trial’s pragmatic character and ensure that the intervention, if effective, can be translated into routine primary care practice, allowing important public health benefits.

Trial registration
ClinicalTrials.gov (NCT05351359, 28/04/2022).
“I’ve kept going” – a multisite repeated cross-sectional study of healthcare workers’ pride in personal performance during the COVID-19 pandemic
Authors: Bondjers Kristina , Lingaas Ingebjørg , Stensland Synne , Atar Dan , Zwart John-Anker , Wøien Hilde , Dyb Grete 
Published: March 2023

Abstract
Background
For healthcare workers, working through a pandemic may include both challenges, such as coping with increased demands and a lack of control, and rewards, such as experiencing a sense of achievement and meaningfulness. In this study, we explore the accomplishments healthcare workers themselves are proud of achieving at work, in order to elucidate the positive aspects of working through a pandemic.

Methods
In June 2020 (T1), December 2020 (T2), and May 2021 (T3), healthcare workers (n = 1,996) at four Norwegian hospitals participated in a web-based survey assessing job strain, psychological health, and support during the pandemic. The survey included the open-ended question “During the past two weeks, what have you been feeling proud of achieving at work?”. Responses (1,046) to this item were analyzed using conventional content analysis, which resulted in 13 subthemes under 6 themes.

Results
For some, pride was found in their professional identity and dedication to their work. Others took pride in specific achievements, such as juggling their own needs (e.g., health, private life) with those of the workplace, contributing to cohesion and collaboration, their ability to learn and adjust, in being a useful resource at work, and in their efforts towards developing the organization and workplace.

Implications
The current findings shed light on what healthcare workers feel proud of achieving in their day-to-day work. Assessment of these factors provides insight on both positive and negative aspects of working clinically during a pandemic, and highlights specific targets for building sustainable and rewarding work environments for healthcare workers.
Unfolding alignment – How top management work to align demand and capacity: an ethnographic study of resilience in a Swedish healthcare region
Authors: Svensson Ingrid , von Knorring Mia , Hagerman Heidi , Fagerström Cecilia , Ekstedt Mirjam , Smeds Alenius Lisa 
Published: March 2023

Abstract
Background
Resilient healthcare organizations maintain critical functions and high-quality care under varying conditions. While previous research has focused on the activities of frontline healthcare professionals working at the “sharp end” of care, less attention has been paid to managers at the top management level. More knowledge is needed to fully understand how the managers align demand and capacity at the “blunt end” of care. Therefore, this study aimed to explore how top managers work to align demand and capacity in a healthcare region in Sweden.

Methods
Observations of management team meetings, interviews, and conversations were conducted with top managers responsible for healthcare in one of Sweden’s 21 regions. Data collection used an ethnographic approach. Data were analyzed using qualitative reflexive thematic analysis.

Results
The data showed how alignment work was done through active reflection that built on past experiences and on structures built into the organization at the same time as taking future potential outcomes and consequences into account. In addition to collaborative, preventive, supportive, and contextualizing work, which was conducted in the present, a general approach permeated the organization, which enabled connecting actions, i.e., different forms of alignment work, occurring at different points in time, and connecting different types of knowledge across organizational borders and stakeholders.

Conclusion
This study explored how top managers work to align demand and capacity in a healthcare region in Sweden. It was shown how four categories of work; collaborative, preventive, supportive and contextualization work, together with a general approach; focusing on opportunities, building on a stable past and taking a reflective stance, constitute alignment in practice. More; the alignment work was done in the here and now, with both the past and future in mind. The ability to take action to benefit the whole is a possibility and a responsibility for top management. In the region studied, this was done by aligning demands with capacity based on past experiences and focusing on the available opportunities to connect knowledge needed within and across organizational borders.
Critical care pharmacy workforce: a 2020 re-evaluation of the UK deployment and characteristics
Authors: Borthwick Mark , Barton Greg , Ioannides Christopher P. , Forrest Ruth , Graham-Clarke Emma , Hanks Fraser , James Christie , Kean David , Sapsford David , Timmins Alan , Tomlin Mark , Warburton John , Bourne Richard S. 
Published: March 2023

Abstract
Introduction
Critical care pharmacists improve the quality and efficiency of medication therapy whilst reducing treatment costs where they are available. UK critical care pharmacist deployment was described in 2015, highlighting a deficit in numbers, experience level, and critical care access to pharmacy services over the 7-day week. Since then, national workforce standards have been emphasised, quality indicators published, and service commissioning documents produced, reinforced by care quality assessments. Whether these initiatives have resulted in further development of the UK critical care pharmacy workforce is unknown. This evaluation provides a 2020 status update.

Methods
The 2015 electronic data entry tool was updated and circulated for completion by UK critical care pharmacists. The tool captured workforce data disposition as it was just prior to the COVID-19 pandemic, at critical care unit level.

Main findings
Data were received for 334 critical care units from 203 organisations (96% of UK critical care units). Overall, 98.2% of UK critical care units had specific clinical pharmacist time dedicated to the unit. The median weekday pharmacist input to each level 3 equivalent bed was 0.066 (0.043–0.088) whole time equivalents, a significant increase from the median position in 2015 (+ 0.021, p < 0.0001). Despite this progress, pharmacist availability remains below national minimum standards (0.1/level 3 equivalent bed). Most units (71.9%) had access to prescribing pharmacists. Geographical variation in pharmacist staffing levels were evident, and weekend services remain extremely limited.

Conclusions
Availability of clinical pharmacists in UK adult critical care units is improving. However, national standards are not routinely met despite widely publicised quality indicators, commissioning specifications, and assessments. Additional measures are needed to address persistent deficits and realise gains in organisational and patient-level outcomes. These measures must include promotion of cross-professional collaborative working, adjusted funding models, and a nationally recognised training pathway for critical care pharmacists.
Machine Learning Models Using Routinely Collected Clinical Data Offer Robust and Interpretable Predictions of 90-Day Unplanned Acute Care Use for Cancer Immunotherapy Patients
Authors: Lu Sheng-Chieh , Knafl Mark , Turin Anastasia , Offodile Anaeze C. , Ravi Vinod , Sidey-Gibbons Chris 
Published: March 2023

PURPOSE Clinical management of patients receiving immune checkpoint inhibitors (ICIs) could be informed using accurate predictive tools to identify patients at risk of short-term acute care utilization (ACU). We used routinely collected data to develop and assess machine learning (ML) algorithms to predict unplanned ACU within 90 days of ICI treatment initiation. METHODS We used aggregated electronic health record data from 7,960 patients receiving ICI treatments to train and assess eight ML algorithms. We developed the models using pre–SARS-COV-19 COVID-19 data generated between January 2016 and February 2020. We validated our algorithms using data collected between March 2020 and June 2022 (peri–COVID-19 sample). We assessed performance using area under the receiver operating characteristic curves (AUROC), sensitivity, specificity, and calibration plots. We derived intuitive explanations of predictions using variable importance and Shapley additive explanation analyses. We assessed the marginal performance of ML models compared with that of univariate and multivariate logistic regression (LR) models. RESULTS Most algorithms significantly outperformed the univariate and multivariate LR models. The extreme gradient boosting trees (XGBT) algorithm demonstrated the best overall performance (AUROC, 0.70; sensitivity, 0.53; specificity, 0.74) on the peri–COVID-19 sample. The algorithm performance was stable across both pre– and peri–COVID-19 samples, as well as ICI regimen and cancer groups. Type of ICI agents, oxygen saturation, diastolic blood pressure, albumin level, platelet count, immature granulocytes, absolute monocyte, chloride level, red cell distribution width, and alcohol intake were the top 10 key predictors used by the XGBT algorithm. CONCLUSION Machine learning algorithms trained using routinely collected data outperformed traditional statistical models when predicting 90-day ACU. The XGBT algorithm has the potential to identify high–ACU risk patients and enable preventive interventions to avoid ACU.
Accelerated abdominal lipid depletion from pesticide treatment alters honey bee pollen foraging strategy, but not onset, in worker honey bees
Authors: Elizabeth Deeter Megan , Snyder Lucy A. , Meador Charlotte , Corby-Harris Vanessa 
Published: March 2023

ABSTRACT
Honey bee abdominal lipids decline with age, a change thought to be associated with the onset of foraging behavior. Stressors, such as pesticides, may accelerate this decline by mobilizing internal lipid to facilitate the stress response. Whether bees with stressor-induced accelerated lipid loss vary from controls in both the onset of foraging and nutritional quality of collected pollen is not fully understood. We asked whether stressors affect foraging behavior through the depletion of abdominal lipid, and whether stress-induced lipid depletion causes bees to forage earlier and for fattier pollen. We tested this by treating newly emerged bees with one of two pesticides, pyriproxyfen (a juvenile hormone analog) and spirodiclofen (a fatty acid synthesis disruptor), that may affect energy homeostasis in non-target insects. Bees fed these pesticides were returned to hives to observe the onset of foraging behavior. We also sampled foraging bees to assay both abdominal lipids and dietary lipid content of their corbicular pollen. Initially, spirodiclofen-treated bees had significantly more abdominal lipids, but these declined faster compared with controls. These bees also collected less, yet more lipid-rich, pollen. Our results suggest that bees with accelerated lipid decline rely on dietary lipid content and must collect fattier pollen to compensate. Pyriproxyfen treatment reduced the age at first forage but did not affect abdominal or collected pollen lipid levels, suggesting that accelerated fat body depletion is not a prerequisite for precocious foraging.
Sequential Adversarial Anomaly Detection for One-Class Event Data
Authors: Zhu Shixiang , Yuchi Henry Shaowu , Zhang Minghe , Xie Yao 
Published: March 2023

We consider the sequential anomaly detection problem in the one-class setting when only the anomalous sequences are available and propose an adversarial sequential detector by solving a minimax problem to find an optimal detector against the worst-case sequences from a generator. The generator captures the dependence in sequential events using the marked point process model. The detector sequentially evaluates the likelihood of a test sequence and compares it with a time-varying threshold, also learned from data through the minimax problem. We demonstrate our proposed method’s good performance using numerical experiments on simulations and proprietary large-scale credit card fraud data sets. The proposed method can generally apply to detecting anomalous sequences. History: W. Nick Street served as the senior editor for this article. Funding: This work is partially supported by the National Science Foundation [Grants CAREER CCF-1650913, DMS-1938106, and DMS-1830210] and grant support from Macy’s Technology. Data Ethics & Reproducibility Note: The code capsule is available on Code Ocean at https://doi.org/10.24433/CO.2329910.v1 and in the e-Companion to this article (available at https://doi.org/10.1287/ijds.2023.0026 ).