bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tailoring Exciton Dynamics in TMDC Heterobilayers in the Quantum Plasmonic Regime
Authors: Rahaman Mahfujur , Kim Gwangwoo , Ma Kyung-Yeol , Song Seunguk , Shin Hyeon Suk , Jariwala Deep 
Published: June 2023

Abstract
Control of excitons in transition metal dichalcogenides (TMDCs) and their heterostructures is fundamentally interesting for tailoring light-matter interactions and exploring their potential applications in high-efficiency optoelectronic and nonlinear photonic devices. While both intra- and interlayer excitons in TMDCs have been heavily studied, their behavior in the quantum tunneling regime, in which the TMDC or its heterostructure is optically excited and concurrently serves as a tunnel junction barrier, remains unexplored. Here, using the degree of freedom of a metallic probe in an atomic force microscope, we investigated both intralayer and interlayer excitons dynamics in TMDC heterobilayers via locally controlled junction current in a finely tuned sub-nanometer tip-sample cavity. Our tip-enhanced photoluminescence measurements reveal a significantly different exciton-quantum plasmon coupling for intralayer and interlayer excitons due to different orientation of the dipoles of the respective e-h pairs. Using a steady-state rate equation fit, we extracted field gradients, radiative and nonradiative relaxation rates for excitons in the quantum tunneling regime with and without junction current. Our results show that tip-induced radiative (nonradiative) relaxation of intralayer (interlayer) excitons becomes dominant in the quantum tunneling regime due to the Purcell effect. These findings have important implications for near-field probing of excitonic materials in the strong-coupling regime.
QTL mapping of human retina DNA methylation identifies 87 gene-epigenome interactions in age-related macular degeneration
Authors: Advani Jayshree , Mehta Puja A. , Hamel Andrew R. , Mahrotra Sudeep , Kiel Christina , Strunz Tobias , Corso-Diaz Ximena , Kwicklis Madeline , Asten Freekje van , Ratnapriya Rinki , Chew Emily Y. , Hernandez Dena G. , Montezuma Sandra R. , Ferrington Deborah A. , Weber Bernhard H. F. , Segrè Ayellet V. , Swaroop Anand 
Published: June 2023

Abstract
DNA methylation (DNAm) provides a crucial epigenetic mark linking genetic variations to environmental influence. We analyzed array-based DNAm profiles of 160 human retinas with co-measured RNA-seq and > 8 million genetic variants, uncovering sites of genetic regulation in cis (37,453 mQTLs and 12,505 eQTLs) and 13,747 eQTMs (DNAm loci affecting gene expression), with over one-third specific to the retina. mQTLs and eQTMs show non-random distribution and enrichment of biological processes related to synapse, mitochondria, and catabolism. Summary data-based Mendelian randomization and colocalization analyses identify 87 target genes where methylation and gene-expression changes likely mediate the genotype effect on age-related macular degeneration (AMD). Integrated pathway analysis reveals epigenetic regulation of immune response and metabolism including the glutathione pathway and glycolysis. Our study thus defines key roles of genetic variations driving methylation changes, prioritizes epigenetic control of gene expression, and suggests frameworks for regulation of AMD pathology by genotype–environment interaction in retina.
A maize phytochrome-interacting factor ZmPIF3 improves salt stress tolerance in transgenic Arabidopsis seedlings
Authors: han zan ping , Liu Haohao , Zhao Xiyong , Zhang Jun , Guo Shulei , Wang Bin , Zhao Linxi , Jin Yunqian , Guo Yiyang , Tian Lei 
Published: June 2023

Abstract
Soil salinization as a kind of natural stress causes soil desertification. High levels of Na+ in the soil will induce the disorder of the internal environment, slow cellular metabolism, and alter the cellular architecture, severely affecting the yield and variety of crops. Maize as a salt-susceptible crop, is always injured by salt stress. So it has a guiding significance for maize breeding to study the molecular mechanism. It has been reported that PIF3 was involved in freezing tolerance, however, the relationship between PIF3 and stress tolerance is little known. In this study, two transcription version of ZmPIF3, ZmPIF3.1 and ZmPIF3.2 was used for the analysis of phenotype, physiology, biochemistry index, and transcriptome analysis. The result showed that ZmPIF3.1 over-expressed transgenic Arabidopsis has better salt tolerance, and displayed better ability to decompose peroxide and membrane damage. Transcriptome analysis showed hormones, Ca2+ signaling, and transcription factors may be associated with salt stress response mediated by ZmPIF3.1. Summarily, this study is the first study to demonstrate that ZmPIF3 can elevate plant salt tolerance, unveiling the new functional role of phytochrome-interacting factors.
A Lagrangian perspective on the carbon and oxygen budget of an oceanic eddy
Authors: Baudena Alberto , Laxenaire Rémi , Catalano Camille , Claustre Hervé , Ioannou Artemis , Leymarie Edouard , Picheral Marc , Poteau Antoine , Speich Sabrina , Stemmann Lars , Kiko Rainer 
Published: June 2023

Abstract
Quantifying the ocean's ability to sequester atmospheric carbon is essential in a climate change context. Measurements of carbon exported to the mesopelagic seldom balance the carbon demand or the oxygen consumption there, suggesting the potential presence of other mechanisms of carbon export. We deployed a BGC Argo float in a cyclone in the Benguela upwelling system for five months in a quasi Lagrangian way, and estimated carbon export and respiration in the eddy via particle imagery with a UVP6. We found that the full eddy core subduction pump, a novel mechanism of particulate carbon export identified here, contributes to one third of the total exported carbon below 450 m (785±355 tons C/day). Moreover, we can balance the carbon supply, carbon demand, and the oxygen consumption if we extrapolate the observed particle size distribution (0.102-16.4 mm) down to 0.025 mm
Study on the characteristics of soil erosion on different land use slopes and its influencing factors in the Loess Hilly and Gully Region
Authors: Gao lei , Wu Ji , Yang Guang , Lu Naijing , Guo Xinyu 
Published: June 2023

Abstract
In order to explore the characteristics and influencing factors of soil and water loss on different land use slopes in the loess hilly and gully region, based on the monitoring data of runoff plots in the soil and water conservation monitoring station of the contract gully small watershed in Dalate Banner, Inner Mongolia from 2018 to 2022, the characteristics of slope runoff and soil loss of natural grassland, artificial grassland, crop land, shrub land, arbor forest land and bare land control group under different rainfall patterns and different slope conditions were analyzed, and the influence of various factors such as rainfall, vegetation and underlying surface on slope erosion was analyzed by path principle. The results showed that : (1) There were significant differences in the response of runoff and erosion to different rainfall types and slopes in runoff plots of different land use types. Compared with bare land, other land use types had obvious runoff and sediment reduction benefits, and the sediment reduction benefits were significantly higher than the runoff reduction benefits. And the soil and water conservation benefits are generally shown as arbor forest land > shrub land > artificial grassland > natural grassland > crop land. (2) Rainfall, vegetation, underlying surface and other influencing factors have a significant impact on slope soil erosion. Rainfall intensity is the most important rainfall index affecting slope runoff. There is a significant positive correlation between runoff and soil loss. Regulating runoff can effectively reduce soil loss. Land use type is the main controlling factor to inhibit slope soil erosion, and it can reduce the impact of various factors on slope erosion by combining with other factors. Through the study of slope erosion characteristics and its influencing factors of different land use, in order to provide a scientific basis for the comprehensive management of soil erosion and the rational allocation of soil and water conservation measures in the loess hilly and gully region.
Prognostic significance of programmed cell death-ligand 1 expression on circulating tumor cells in lung cancers: systematic review and meta-analysis
Authors: Wang Jin , Chen Shuang , Shi Zhigang , Li Yang , Han Lu 
Published: June 2023

Abstract
Background
This meta-analysis aims to investigate the correlation between programmed cell death-ligand 1 (PD-L1) expression on circulating tumor cells (CTCs) and its prognostic significance.
Methods
The authors retrieved literature databases for eligible studies published before January 10, 2023. Hazard ratio (HR) with 95% confidence interval (CI) was used to assess the correlation between PD-L1 expression on CTCs and overall survival (OS) and progression-free survival (PFS).
Results
This study included 10 articles involving 731 patients. The pooled results showed that PD-L1+ CTCs were significantly associated with OS (HR = 1.87, 95% CI 1.02–3.44, P = 0.04) but not with PFS (HR = 1.19, 95% CI 0.77–1.82, p = 0.43). The subgroup analysis demonstrated that PD-L1+ CTCs were associated with worse PFS (HR = 1.19, 95% CI 0.77–1.82, P = 0.03) and OS(HR = 2.05, 95% CI 1.5–2.8, P༜0.01) for patients who received back-line immune checkpoint inhibitors (ICIs) treatment. No significant clinical significance was observed for PFS when considering CTCs enrichment and cutoff. In the immunologic enrichment group, PD-L1+ CTCs were associated with worse OS (HR = 2.48, 95% CI 1.43–4.29, P=0.001). Regarding the PD-L1 detection method and region, PD-L1+ CTCs were associated with worse PFS/OS in the IF and European groups.
Conclusions
The expression of PD-L1 on circulating tumor cells (CTCs) is a promising prognostic marker for lung cancer, particularly in patients who received back line ICIs treatment.
Single cell analysis of epithelial, immune, and stromal signatures and interactions in human ovarian cancer
Authors: Chai Chaochao , Liang Langchao , Wang Wei , Zhao Wandong , Sun Chengcheng , Lin Lin , Li Hanbo , Wang Fei , Luo Yonglun 
Published: June 2023

Abstract
A comprehensive investigation of ovarian cancer development at the single-cell level is crucial for enhancing our understanding of the disease, as well as for the development of better diagnosis and treatments. In this study, we examined over half a million single-cell transcriptome data of 84 ovarian tumor patients across all clinical stages. Through integrative analysis, we identified heterogeneous epithelial-immune-stromal cellular compartments and their interactions in ovarian cancers. The epithelial cells displayed clinical subtype features with functional variance. Notably, we observed a significant increase in distinct T cell subtypes, including Tregs and CD8 + exhausted T cells after stage IC2. Additionally, we discovered antigen-presenting cancer-associated fibroblasts (CAFs), with myofibroblastic CAFs (myCAFs) exhibiting enriched extracellular matrix (ECM) functionality linked to tumor progression at stage IC2. We identified the NECTIN2-TIGIT ligand-receptor pair mediating T cell communication with epithelial, fibroblast, endothelial and other cell types. These findings shed light on the cellular compartments and functional aspects of ovarian cancer, providing insights into the molecular mechanisms underlying stage IC2 and potential therapeutic strategies for the disease.
A case report of Asymptomatic hyperCKemia and literature review
Authors: luo Meng , Huang Xuerong , Wang Wenhui , He Qingjun , Zhou Chunhong , Lin Yingyu , Fan Chunxiao , Pi Jianbin 
Published: June 2023

Abstract
Background: Asymptomatic hyperCKemia is a disease with significant clinical heterogeneity. The European union of Neurology has determined that the creatine kinase value of Asymptomatic hyperCKemia as 1.5 times higher than the upper limit of normal value.
Case presentation: This paper reports a young woman with elevated creatine kinase found by physical examination after in-hospital examination and follow-up, the diagnosis of Asymptomatic hyperCKemia was confirmed.
Conclusion: The pathogenesis of the disease is complex and the etiology is diverse, so the author believes that it is extremely necessary to improve the ability of medical workers to identify and diagnose the disease and avoid missed diagnosis and misdiagnosis as far as possible to improve the prognosis of such patients.
Does Faster Weight Trajectory Lead to Improved Neurodevelopmental Outcomes in ELBW Infants with Bronchopulmonary Dysplasia?
Authors: Carter Emily , Edwards Erika , Jerome Maggie , Litt Jonathan , Munoz Fernando 
Published: June 2023

Abstract
Objective: To examine the relationship between weight trajectory and 2-year neurodevelopmental outcomes for extremely low birthweight (ELBW) infants with BPD.
Study Design:Secondary analysis of infants born from 2010 to 2019. The predictor was BPD severity and the outcome was neurodevelopmental impairment, defined as any Bayley Scales of Infant Development (BSID) III score <70 at 24 months’ corrected age. Repeated measures logistic regression was performed.
Results: There were 5,042 infants included. Faster weight trajectory was significantly associated with a decreased probability of having at least one BSID III score <70 for infants with grade 1-2 BPD (p<0.0001) and an increased probability of having at least one BSID III score <70 for infants with grade 3 BPD (p<0.009). There was no significant association between weight trajectory and BSID III score <70 for infants with grade 0 BPD.
Conclusion: The association between postnatal weight trajectory and neurodevelopmental outcome differs by BPD severity.
Structural Organization of the Retriever-CCC Endosomal Recycling Complex
Authors: Boesch Daniel , Singla Amika , Han Yan , Kramer Daniel , Liu Qi , Suzuki Kohei , Juneja Puneet , Zhao Xuefeng , Long Xin , Medlyn Michael , Billadeau Daniel , Chen Zhe , Chen Baoyu , Burstein Ezra 
Published: June 2023

Abstract
The recycling of membrane proteins from endosomes to the cell surface is vital for cell signaling and survival. Retriever, a trimeric complex of VPS35L, VPS26C and VPS29, together with the CCC complex comprising CCDC22, CCDC93, and COMMD proteins, plays a crucial role in this process. The precise mechanisms underlying Retriever assembly and its interaction with CCC have remained elusive. Here, we present the first high-resolution structure of Retriever determined using cryogenic electron microscopy. The structure reveals a unique assembly mechanism, distinguishing it from its remotely related paralog, Retromer. By combining AlphaFold predictions and biochemical, cellular, and proteomic analyses, we further elucidate the structural organization of the entire Retriever-CCC complex and uncover how cancer-associated mutations disrupt complex formation and impair membrane protein homeostasis. These findings provide a fundamental framework for understanding the biological and pathological implications associated with Retriever-CCC-mediated endosomal recycling.
Protection from Particulate Matter and Infection: Thermal Imaging and Deep Learning-based Fit-checking of Quasi-drug Masks
Authors: Kim Hyunjin , Kim Tong Min , Choi Sae Won , Ko Taehoon 
Published: June 2023

Abstract
Background
Particulate matter and infectious diseases confer serious health risks, particularly in healthcare workers who experience occupational exposure risk. Masks can provide effective protection against such risks, although their efficacy is only as good as their fit. Therefore, a fit test is performed to ensure correct fit of the mask. In this study, we aimed to develop an artificial intelligence system to quickly and easily determine correct mask-wearing in real time using thermal videos that ascertained temperature changes caused by air trapped inside the mask.
Methods
We investigated the effectiveness of deep learning-based identification of the correct way to wear a mask based on thermal videos with five types of masks, which were approved as quasi-drugs by the Korean Ministry of Food and Drug Safety, and four ways of wearing these masks including one proper way and three improper ways. The same conditions were repeated five times, with a total of 100 videos per participant, and 5000 videos were obtained in this study. We used a 3D Convolutional Neural Network (3DCNN) and Convolutional Long Short-Term Memory (ConvLSTM) for data analysis. Both models performed binary and multi-classification to categorize mask-wearing.
Results
3DCNN performed better than ConvLSTM by achieving higher scores in both binary and multi-classification tasks. The AUROC value for multi-classification using 3DCNN was the highest at 0.986 whereas the remaining parameters of accuracy, precision, recall, specificity, and F1-score were all better with the binary classification. All mask types showed AUROC values > 0.9, with KF-AD being the best classified.
Conclusion
This novel approach uses thermal imaging and deep learning techniques to effectively monitor correct mask-wearing and could be useful in high-risk environments, including in healthcare settings. This method can be applied to various mask types, which enables easy generalizability and advantages in public and occupational health and healthcare. Furthermore, integrating this novel technology into other screening methods can improve the safety and well-being of people, including healthcare workers, in various situations.
Vortioxetine alleviates PTSD-like behaviors by regulating ABPs through up-regulating FMRP in the hippocampus of rats exposed to SPS
Authors: Yang Shu-Ting , An Qi , Cao Chen-Feng , Kuang Jia-Qi , Li Miao , Ji Li-Li 
Published: June 2023

Abstract
Posttraumatic stress disorder (PTSD) is a mental disorder that may lead to a series of changes in the central nervous system, including damage to synaptic plasticity, loss of neuronal dendritic spine, increased apoptosis or inflammation. However, the pathogenesis of PTSD is still unclear and there are few efficacious pharmacological treatments for PTSD. In the present study, we found that intraperitoneal injection of vortioxetine could alleviate PTSD-like behaviors including depression-like behavior and fear memory extinction disorder of rats exposed tosingle-prolonged stress (SPS). This effect might be related to the upregulation of FMRP in the hippocampus of SPS rats. Furthermore, vortioxetine could also increase the dendritic spine density and the expression of synapse-related proteins, including PSD95 and synapsin I and Actin-binding proteins (ABPs), such as drebrin1, profilin2 and p-cofilin1 in hippocampal cell of rats exposed to SPS. The results of this study indicated that vortioxetine might alleviate PTSD-like behaviors by regulating neuronal morphology in the hippocampus of rats exposed to SPS through regulating FMRP, which might be related to the regulation of synapse-related proteins and ABPs.
The Apoptotic Effect of The Lycopodium Clavatum Extracts on MCF-7 Human Breast Cancer Cells
Authors: Kucukbagriacik Yusuf , Dastouri Mohammadreza , Yilmaz Humeyra , Altuntas Evrim Gunes 
Published: June 2023

Abstract
Breast cancer is a significant health problem worldwide, and the search for effective treatments is critical. Side effects of cancer treatments such as surgery, radiotherapy, and chemotherapy reduce the patient's standard of living. Recently, natural compounds from plants have gained attention as potential anticancer agents due to their safety, low toxicity, and potential efficacy. Lycopodium Clavatum (LC) is an herb abundant in tropical regions and Europe and is known for its various medicinal properties. In this study, we investigated the cytotoxic and apoptotic effects of LC Water Extract (LC-WE) and LC Ethanol Extract (LC-EE) plant extracts on MCF-7 human breast cancer cells. Our results showed that LC treatment led to a dose and time-dependent cytotoxic effect on MCF-7 cells, indicating its potential as an anticancer agent against human breast cancer. Additionally, we observed that LC treatment activated apoptosis-related proteins, including BAX, Caspase-3, and Caspase-9. These results suggest that LC may induce apoptosis as a mechanism underlying its cytotoxic effect on MCF-7 human breast cancer cells. Previous studies have shown the anti-cancer potential of LC against different types of cancer. However, the anti-cancer effect of LC on human breast cancer cells has not been investigated to date. Therefore, our study provides novel insights into the potential of LC as an anti-cancer agent against breast cancer. Overall, our results highlight the potential of LC as a promising natural compound for breast cancer treatment.
Rotator cuff tears and mid-term shoulder outcomes after intramedullary nail fixation for humeral shaft fracture: a minimum 5-year follow-up study
Authors: Furuhata Ryogo , Tanji Atsushi , Nakamura Soichiro , Urabe Tadahisa 
Published: June 2023

Abstract
Background
Antegrade intramedullary nail fixation for humeral shaft fractures yields satisfactory union rates. However, one concern is damage to the rotator cuff during nail insertion, which may affect long-term outcomes. The effect of rotator cuff lesion on mid- and long-term shoulder outcomes remains unknown. This study aimed to investigate the incidence of rotator cuff tears 5 years or more after intramedullary nailing for humeral shaft fractures, and to determine the impact of postoperative rotator cuff tears on mid-term outcomes.
Methods
We retrospectively identified 22 patients who underwent antegrade intramedullary nail fixation for traumatic humeral shaft fractures and received follow-up for at least 5 years postoperatively. We divided the patients into those without tears and those with partial or complete tears, diagnosed using ultrasonography. We compared the functional and radiological shoulder outcomes between the two groups.
Results
Of 22 patients, nine had partial or complete supraspinatus tears at a mean follow-up of 7.5 years postoperatively. The incidence of acromial spurs was significantly higher in patients with partial or complete tears than in those without tears (P = 0.002). There were no significant differences in age and gender-adjusted Constant score, and American Shoulder and Elbow Surgeon score between the two groups.
Conclusions
Our results showed that 41% of patients developed partial or complete supraspinatus tendon tears in the mid-term. Postoperative rotator cuff tears were significantly associated with the formation of acromial spurs; however, it had no significant effect on shoulder functional outcomes.