bluuebunny/crossref_metadata_2025_split huggingface dataset:
Myocardial revascularization failure among patients requiring cardiac catheterization and secondary revascularization in contemporary clinical practice: Results of the REVASEC multicenter registry
Authors: Salinas Pablo , García‐Camarero Tamara , Jimenez‐Kockar Marcelo , Regueiro Ander , García‐Blas Sergio , Gomez‐Menchero Antonio E. , Ojeda Soledad , Vilchez‐Tschischke Jean Paul , Amat‐Santos Ignacio , Díez‐Gil Jose Luis , Rondán Juan , Lozano Ruiz‐Poveda Fernando , de Miguel Castro Antonio , Manzano Maria C. , Pascual‐Tejerina Virginia , Cruz‐González Ignacio , García Perez‐Velasco Javier , Fernández‐Diaz Jose A. , Escaned Javier ,   REVASEC working group (collaborators)
Published: August 2023

AbstractBackgroundMyocardial revascularization failure (MRF) and Secondary revascularization (SR) are contemporary interventional cardiology challenges.AimTo investigate the characteristics, management, and prognosis of patients with myocardial revascularization failure (MRF) and need for secondary revascularization (SR) in contemporary practice.MethodsThe REVASEC study is a prospective registry (NCT03349385), which recruited patients with prior revascularization referred for coronary angiography at 19 centers. The primary endpoint is a patient‐oriented composite (POCE) at 1 year, including death, myocardial infarction, or repeat revascularization.ResultsA total of 869 patients previously revascularized by percutaneous intervention (83%) or surgery (17%) were recruited. MRF was found in 83.7% (41.1% stent/graft failure, 32.1% progression of coronary disease, and 10.5% residual disease). SR was performed in 70.1%, preferably by percutaneous intervention (95%). The POCE rate at 1 year was 14% in the overall cohort, with 6.4% all‐cause death. In the multivariate analysis, lower POCE rates were found in the groups without MRF (9.4%) and with disease progression (11%) compared with graft/stent failure (17%) and residual disease (18%), hazard ratio 0.67 (95% confidence interval: 0.45–0.99), p = 0.043. At 1 year, the SR group had less chronic persistent angina (19% vs. 34%, p < 0.001), but a higher rate of repeat revascularization (9% vs. 2.9%, p < 0.001).ConclusionMRF was found in 84% of patients with prior revascularization referred for coronary angiography. Stent/graft failure and residual coronary disease were associated with a worse prognosis. SR provided better symptom control at the expense of a higher rate of new revascularization
Cooperative Bimetallic Co−Mn Catalyst: Exploiting Metallo‐Organic and Hydrogen Bonded Interactions for Rechargeable C‐/N‐Alkylation
Authors: Shivaji Padmor Manohar , Vishwakarma Palak , Tothadi Srinu , Pratihar Sanjay 
Published: August 2023

AbstractDespite the progress on cobalt and manganese catalyzed C−C and C−N bond‐forming methodologies, the associated catalyst reusability remains with some unresolved issue, which needs to be addressed. Disclosed herein, a flexible multidentate proton‐responsive ligand (L) bearing 2,6‐bis(1H‐benzo[d]imidazol‐2‐yl)pyridine (BBP), 6‐(1H‐benzo[d]imidazol‐2‐yl)picolinic acid (BPA), and benzene‐1,2‐diamine (BDA) for Co/Mn‐based mono‐ and bi‐metallic supramolecular materials for C‐/N‐alkylation of alcohols. The flexible binding sites and different hydrogen bond donor‐acceptor fragments of L brings the rigidity and self‐assembling to ordered crystalline supramolecular materials, which prevented the coordinatively saturated active sites and thus providing much higher reaction efficiency and selectivity, which is highly unlikely in the case of comparable individual components. The easy synthesis, efficient reactivity and selectivity through cooperativity, broad substrate scope, and efficient recycling via recharging of metals make the catalyst and the protocol economical and sustainable. Importantly, the design strategy based on metallo‐organic hydrogen bonded coordination assembly has the potential to contribute to the development of supramolecular materials for various advanced catalytic applications.
Construction of Rings via Metal‐Catalyzed C−H Annulation with Unsymmetrical Internal Alkynes: Selectivity and Applications
Authors: Zhang Qiaoya , Chen Ci , Liu Bairong , Liu Yuan , Gao Yang , Chen Qian , Huo Yanping , Li Xianwei 
Published: August 2023

AbstractSelective and concise construction of ring systems that are ubiquitous skeletons across chemistry, drugs and materials, is indispensable for human life. Of note, directed C−H annulation with alkynes for the expedient delivery of ring systems holds great importance, featuring step‐ and atom‐economy, mild conditions, and broad substrate scope. However, regioselectivity issues remained when using unsymmetrical alkynes for the directed C−H annulation. Herein, we summarized recent achievements towards solving this problem by developing directing groups, metal catalysts, and alkynes with versatile and traceless functionality that ensure the overall regioselectivity, enantioselectivity, efficiency, and synthetic application. We hope this concept will promote the further development of the precise construction of functional molecules using C−H annulation with unsymmetrical alkynes.
Optimizing the Disinfection Inactivation Efficiency in Wastewater Treatment: A Computational Fluid Dynamics Investigation of a Full‐Scale Ozonation Contactor
Authors: Elaissaoui Elmeliani Mohamed El Amine , Aguedal Hakim , Iddou Abdelkader , Alaoui Chakib , Benaissa Brahim , Belhadj Mohamed El Amine , Nguyen The-Anh , Sun Meng , Terashima Mitsuharu 
Published: August 2023

AbstractThe inactivation kinetics of total coliforms to increase the pathogenic removal efficiency in a full‐scale ozonation contactor in a wastewater treatment plant in Algeria is investigated. An enhanced ozone contactor design is proposed and 3D multiphase computational fluid dynamics simulations were conducted to optimize the operating parameters, including flow rates, ozone concentrations considering the treatment performance, and total operating cost. The existing design has several limitations, including poor mass‐transfer efficiency and uneven distribution of dissolved ozone. To address these issues, the optimized design includes new injection‐point settings and an increased number of diffusers. The optimized design achieved a significant improvement in mass transfer efficiency. The ozone treatment effectively reduced the total coliform counts in the wastewater samples compared to the existing design. The Chick‐Watson model predicted inactivation kinetics, with a reduction of up to 99.997 %. The practical implications of this research can significantly improve the inactivation kinetics of ozone treatments.
Biomass Simulation: Orange and Eucalyptus Waste as a Source of Essential Oils Using Solar Energy
Authors: Armenta Gálvez Jesús Manuel , Ayala Bautista José Ramón , Coronado Ortega Marcos Alberto , Montero Alpírez Gisela , Montes Núñez Daniela Guadalupe Lucía , Sagaste Bernal Carlos Alfonso 
Published: August 2023

AbstractOrange processing and wood production industries generate wastes in the form of orange peel and eucalyptus leaves. These residues can be valorized as feedstocks to produce essential oils. Therefore, a simultaneous orange peel and eucalyptus leaves essential oil extraction process integrating solar energy was simulated. Biomass and essential oils were simulated by using equivalence models. The coupling of solar collectors allowed the extraction of eucalyptus essential oil, with a saving of 10 % in the total energy load.
Switchable Selectivity in the Annulation of o‐Trifluoroacetylanilines and Activated Terminal Alkynes Based on Transition Metal and Phosphine Catalysis
Authors: Mitrofanov Alexander Yu. , Murashkina Arina V. , Lyssenko Konstantin A. , Beletskaya Irina P. 
Published: August 2023

AbstractIn this work, we have developed selective methods for the synthesis of quinoline‐2‐carboxylates and quinoline‐3‐carboxylates as well as (indolin‐2‐ylidene)acetates through copper‐, silver‐, or phosphine‐catalyzed reaction of propiolates with 2′‐amino‐2,2,2‐trifluoroacetophenones. The approaches proposed ensure synthesis of substituted quinoline carboxylates and (indolin‐2‐ylidene)acetates in good yields. Introduction of alkynones into the reaction with 2′‐amino‐2,2,2‐trifluoroacetophenones gives acyl substituted derivatives in good yields.
Mit Licht zu grünem Wasserstoff
Authors: Tausch Michael W. , Schneidewind Jacob 
Published: August 2023

ZusammenfassungGrüner Wasserstoff ist ein Hauptakteur in der Energiewende. Während im öffentlichen Diskurs der Fokus auf grünem Wasserstoff liegt, der via Photovoltaik oder Windenergie und Wasserelektrolyse produziert wird, informiert dieser Beitrag über den aktuellen Stand bei der Erforschung der direkten Wasserspaltung mit Licht. Dabei wird eingegangen auf die grundlegenden Konzepte und Prozesse in der Wasserspaltung, bisherige Umsetzungen sowie aktuelle Herausforderungen, um diese Technologie in die Anwendung zu bringen. Um die noch anstehenden Herausforderungen zu überwinden ist auch die Einbindung dieser Thematik in den Chemieunterricht notwendig. Es wird auf Experimente, digitale Medien, und Lehrkonzepte, die dafür entwickelt wurden, hingewiesen.
Contrast tests for groups of functional data
Authors: Do Quyen , Du Pang 
Published: August 2023

AbstractFunctional analysis of variance (ANOVA) models are often used to compare groups of functional data. Similar to the traditional ANOVA model, a common follow‐up procedure to the rejection of the functional ANOVA null hypothesis is to perform functional linear contrast tests to identify which groups have different mean functions. Most existing functional contrast tests assume independent functional observations within each group. In this article, we introduce a new functional linear contrast test procedure that accounts for possible time dependency among functional group members. The test statistic and its normalized version, based on the Karhunen–Loève decomposition of the covariance function and a weak convergence result of the error processes, follow respectively a mixture chi‐squared and a chi‐squared distribution. An extensive simulation study is conducted to compare the empirical performance of the existing and new contrast tests. We also present two applications of these contrast tests to a weather study and a battery‐life study. We provide software implementation and example data in the Supplementary Material.
Robust joint modelling of sparsely observed paired functional data
Authors: Zhou Huiya , Yan Xiaomeng , Zhou Lan 
Published: August 2023

AbstractA reduced‐rank mixed‐effects model is developed for robust modelling of sparsely observed paired functional data. In this model, the curves for each functional variable are summarized using a few functional principal components, and the association of the two functional variables is modelled through the association of the principal component scores. A multivariate‐scale mixture of normal distributions is used to model the principal component scores and the measurement errors in order to handle outlying observations and achieve robust inference. The mean functions and principal component functions are modelled using splines, and roughness penalties are applied to avoid overfitting. An EM algorithm is developed for computation of model fitting and prediction. A simulation study shows that the proposed method outperforms an existing method, which is not designed for robust estimation. The effectiveness of the proposed method is illustrated through an application of fitting multiband light curves of Type Ia supernovae.
A systematic review of the applicability of emergency department assessment of chest pain score‐accelerated diagnostic protocol for risk stratification of patients with chest pain
Authors: Wang Minghu , Hu Zhiwei , Miao Lihui , Shi Manman , Gao Qiang 
Published: August 2023

AbstractThe emergency department assessment of chest pain score‐accelerated diagnostic protocol (EDACS‐ADP) are commonly used for risk stratification in undifferentiated patients with acute chest pain. This systematic review aimed to investigate EDACS‐ADP for risk stratification of emergency department (ED) patients with chest pain. The PubMed, Web of Science, Medline, Cochrane Library, China National Knowledge Infrastructure, and Wanfang databases were searched for related studies without restrictions on the publication year. The Quality Assessment of Diagnostic Accuracy Studies 2 tool was used to assess the risk of bias, and Stata 16.0 was used to determine the combined sensitivity, specificity, positive diagnostic likelihood ratio (DLR), and negative DLR. Twelve studies comprising 14 290 patients were identified. Of these, 7537 (52.74%) patients were considered low risk, and 67 (0.89%) had major adverse cardiovascular events (MACE), including myocardial infarction, stroke, and cardiovascular death within 30 days of the patients' ED presentation. EDACS‐ADP showed a combined sensitivity of 0.97 (95% confidence interval [CI]: 0.95−0.99); specificity, 0.58 (0.53−0.63); positive DLR, 2.34 (2.08−2.63); negative DLR, 0.04 (0.02−0.09); diagnostic odds ratio, 53.11 (26.45−106.63); and summary receiver operating characteristic area under the curve, 0.83 (0.79−0.86). Despite the large statistical heterogeneity of the results, EDACS‐ADP identified a considerable number of low‐risk patients for early discharge, with a specificity >50% and an incidence of MACE within 30‐days of patients' ED presentation <1%. Thus, it is a useful tool with a potential for clinical application.
Anion exchange material based on polyvinylchloride and urea for the removal of chromium(vi) ions from aqueous solutions
Authors: Bekchanov Davronbek , Mukhamediev Mukhtarjan , Babojonova Gulbakhor , Lieberzeit Peter , Su Xintai 
Published: August 2023

AbstractIn this study, an anion exchange material obtained by chemically modifying granulated polyvinyl chloride with urea was examined. To study the structural morphology of the anion exchanger, polymer PVC‐based anion exchange resin second type (PPE‐2), we applied different characterization techniques including X‐ray diffraction (XRD), Fourier‐transform infrared (FTIR), scanning electron microscopy (SEM), and water vapor adsorption analysis. Moreover, PPE‐2 was used to remove hexavalent chromium ions from aqueous media. A pseudo‐second order model was used to describe sorption kinetics as well as the adsorption mechanism. The Langmuir isotherm and the pseudo‐second order kinetic model led to the most consistent results in describing ion removal from solution. In the case of hexavalent chromium ions, the maximum adsorption capacity was 148.4 mg g−1. The Dubinin‐Radushkevich (D‐R) free energy of adsorption (ED) was >16 kJ mol−1, which indicates chemical interaction between the ion exchange material and Cr(VI) ions. The Gibbs energy ΔG, enthalpy ΔH, and entropy ΔS changes during binding showed that the sorption process is spontaneous and involves chemical sorption through endothermic ion exchange reactions. In addition, the results demonstrate that the anion exchanger (PPE‐2) very efficiently removed hexavalent chromium ions from industrial wastewater.
New era for myelofibrosis treatment with novel agents beyond Janus kinase‐inhibitor monotherapy: Focus on clinical development of BCL‐XL/BCL‐2 inhibition with navitoclax
Authors: Pemmaraju Naveen , Garcia Jacqueline S. , Perkins Andrew , Harb Jason G. , Souers Andrew J. , Werner Michael E. , Brown Christopher M. , Passamonti Francesco 
Published: August 2023

AbstractMyelofibrosis is a heterogeneous myeloproliferative neoplasm characterized by chronic inflammation, progressive bone marrow failure, and hepatosplenic extramedullary hematopoiesis. Treatments like Janus kinase inhibitor monotherapy (e.g., ruxolitinib) provide significant spleen and symptom relief but demonstrate limited ability to lead to a durable disease modification. There is an urgent unmet medical need for treatments with a novel mechanism of action that can modify the underlying pathophysiology and affect the disease course of myelofibrosis. This review highlights the role of B‐cell lymphoma (BCL) protein BCL‐extra large (BCL‐XL) in disease pathogenesis and the potential role that navitoclax, a BCL‐extra large/BCL‐2 inhibitor, may have in myelofibrosis treatment.
Disparities in testicular cancer incidence, mortality, and place of death trends from 1999 to 2020: A comprehensive cohort study
Authors: Gold Beck O. , Ghosh Anushka , Goldberg Saveli I. , Chino Fumiko , Efstathiou Jason A. , Kamran Sophia C. 
Published: August 2023

AbstractBackgroundTesticular cancer (TC) mortality rates have decreased over time, however it is unclear whether these improvements are consistent across all communities.AimsThe aim of this study was to analyze trends in TC incidence, mortality, and place of death (PoD) in the United States between 1999–2020 and identify disparities across race, ethnicity, and geographic location.Methods and ResultsThis cross‐sectional study used CDC WONDER and NAACCR, to calculate age‐adjusted rates of TC incidence and mortality, respectively. PoD data for individuals who died of TC were collected from CDC WONDER. Using Joinpoint analysis, longitudinal mortality trends were evaluated by age, race, ethnicity, US census region, and urbanization category. TC stage (localized vs metastatic) trends were also evaluated. Univariate and multivariate regression analysis identified demographic disparities for PoD. A total of 8,456 patients died of TC from 1999–2020. Average annual percent change (AAPC) of testicular cancer‐specific mortality (TCSM) remained largely stable (AAPC, 0.4; 95% CI −0.2 to 0.9; p = 0.215). Men ages 25–29 experienced a significant increase in TCSM (AAPC, 1.3, p = 0.003), consistent with increased metastatic testicular cancer‐specific incidence (TCSI) trend for this age group (AAPC, 1.6; p < 0.01). Mortality increased for Hispanic men (AAPC, 1.7, p < 0.001), with increased metastatic TCSI (AAPC, 2.5; p < 0.001). Finally, younger (<45), single, and Hispanic or Black men were more likely to die in medical facilities (all p < 0.001). The retrospective study design is a limitation.ConclusionSignificant increases in metastatic TC were found for Hispanic men and men aged 25–29 potentially driving increasing testicular cancer specific mortality in these groups. Evidence of racial and ethnic differences in place of death may also highlight treatment disparities.
Facile Formation of Sulfurized Nanorod‐Like ZnO/Zn(OH)2 and Hierarchical Flower‐Like γ‐Zn(OH)2/ϵ‐Zn(OH)2 from a Green Synthesis and Application as Luminescent Solar Concentrator
Authors: Rodrigues Aline Varella , Onishi Bruno Seiki Domingos , Ribeiro Sidney José Lima 
Published: August 2023

AbstractThis research endeavors to overcome the significant challenge of developing materials that simultaneously possess photostability and photosensitivity to UV‐visible irradiation. Sulfurized nanorod (NR)‐like ZnO/Zn(OH)2 and hierarchical flower‐like γ‐Zn(OH)2/ϵ‐Zn(OH)2 were identified from XRD diffraction patterns and Raman vibrational modes. The sulfurized material, observed by FEG‐SEM and TEM, showed diameters ranging from 10 and 40 nm and lengths exceeding 200 nm. The S2− ions intercalated Zn2+, modulating NRs to dumbbell‐like microrods. SAED and HRTEM illustrated the atomic structure in (101) crystal plane. Its direct band gap of 3.0 eV was attributed to the oxygen vacancies, which also contribute to the deep‐level emissions at 422 and 485 nm. BET indicated specific surface area of 4.4 m2 g−1 and pore size as mesoporosity, which are higher compared to the non‐sulfurized analogue. These findings were consistent with the observed photocurrent, photostability and photoluminescence (PL), further supporting the suitability of sulfurized NR‐like ZnO/Zn(OH)2 as a promising candidate for Luminescent solar concentrators (LSC)‐photovoltaic (PV) system.
Voltage‐ and Power‐Conversion Performance of Bi‐functional ZrO2 : Er3+/ Yb3+ Assisted and Co‐sensitized Dye Sensitized Solar Cells for Internet of Things Applications
Authors: Meenakshamma Ambapuram , Mounika Parnapalli Muni , Gurulakshmi Maddala , Susmitha Kalvapalli , Haranath D. , Goswami Lalit , Gupta Govind , Someshwar Pola , Raghavender Mitty 
Published: August 2023

AbstractGiant power conversion efficiency is achieved by using bifunction ZrO2 : Er3+/Yb3+assisted co‐sensitised dye‐sensitized solar cells. The evolution of the crystalline structure and its microstructure are examined by X‐ray diffraction, scanning electron microscopy studies. The bi‐functional behaviour of ZrO2 : Er3+/Yb3+ as upconversion, light scattering is confirmed by emission and diffused reflectance studies. The bi‐function ZrO2 : Er3+/Yb3+ (pH=3) assisted photoanode is co‐sensitized by use of N719 dye, squaraine SPSQ2 dye and is sandwiched with Platinum based counter electrode. The fabricated DSSC exhibited a giant power conversion efficiency of 12.35 % with VOC of 0.71 V, JSC of 27.06 mA/cm2, FF of 0.63. The results, which motivated the development of a small DSSC module, gave 6.21 % and is used to drive a tiny electronic motor in indoor and outdoor lighting conditions. Small‐area DSSCs connected in series have found that a VOC of 4.52 V is sufficient to power up Internet of Things (IoT) devices.
GQD@NiFe‐LDH Nanosheets for Photocatalytic Activity towards Textile Dye Degradation via Lattice Contraction
Authors: Jena Manasi , Mallick Sagar , Rath Ashutosh , Dalai Manas Kumar , Das Dipti P. 
Published: August 2023

AbstractThe functionalized NiFe‐LDH with photosensitized GQDs were synthesized through the hydrothermal route by differing the amount of GQDs solution and studied its efficacy towards the mineralization of textile dyes under visible light. The synthesized samples were characterized by XRD, FESEM, HRTEM, DRUV‐Vis, RAMAN, XPS, and BET. The combined effect of the hexagonal carbon lattice in GQD and open layered porous structure of NiFe‐LDH nanosheets results in the contraction of the lattice. Different reactive and conventional dyes were taken as representative dyes to evaluate the activity of the as‐synthesized photocatalysts. The enhanced electron absorption/donor effect between GQDs and NiFe‐LDH, and the growth of oxygen‐bridged Ni/Fe−C moieties enable the composite to exhibit better photocatalytic activity. Both photocatalytic activity and characterization results confirmed that the GQD@NiFe‐LDH nanocomposite heterostructure synthesized at 160 °C by taking 10 mL of GQDs aqueous solution named GNFLDH10 has a higher degree of crystallinity and has the best photocatalytic efficiency compared to other reported visible light catalysts. Specifically, the above optimized GQD@NiFe‐LDH photocatalyst is capable of photo‐mineralizing 50 ppm of Reactive Green in 20 min, Reactive Red in 20 min, and Congo Red in 25 min respectively following a direct Z‐scheme mechanism with substantial reusability.
Government institutions and persistent communal conflicts in Nigeria
Authors: Fatai Adeleke Gbadebo , Olufemi Lawal Musediq , Olubunmi Lanre‐Babalola Folake , Oluwakemi Akinpelu Temitope 
Published: August 2023

AbstractAgainst the backdrop of scholarship on the internal causes of conflicts, this study examined how government institutions externally fuel persistent communal conflicts (PCC) in Nigeria. With multiple methods and triangulation of sampling techniques, we examined 12 pairs of warring communities, 4464 respondents, and 18 key interviewees. The causes of PCC were misapplication of constitutional/legal instruments and biased enforcement administration that favored one community over the other. Through matrix correlation, institutions like constitution and legal mechanisms, peace‐building mechanisms, and the enforcement agents' roles fuelled PCC among the warring communities. This correlation has a negative relationship that led to the people's loss of confidence in the umpires, vengeance, jungle justice and intolerance among the warring communities. We concluded that these institutional lapses created a class of disadvantaged and aggressive victims who have become intolerant of other communities. There is a need to sanitize governmental institutions to treat communal disputes with justice and fairness.