bluuebunny/crossref_metadata_2025_split huggingface dataset:
Serum Anti-Müllerian Hormone Is an Effective Indicator of Antral Follicle Counts but Not Primordial Follicle Counts
Authors: Zhou Yiran , Scott Kate L , Quin Eilish , Pankhurst Michael W 
Published: June 2023

Abstract
Serum anti-Müllerian hormone (AMH) is a biomarker for predicting antral follicle counts but there is no clear consensus on whether AMH is indicative of primordial follicle counts in humans. Mice were used as a model species in this study to obtain accurate follicle counts across the reproductive phase of life. Serum AMH was measured in 62 female C57Bl6/J mice aged 25 to 401 days. Primordial and primary follicles were determined by stereological counts and all secondary and antral follicles were counted in serial histological sections. Serum AMH was most strongly correlated with small- and medium-sized antral follicles. Immunohistochemistry and stepwise multiple regression confirmed that these follicle development stages are the key determinants of serum AMH, with little contribution from other stages. Primordial follicles were not found to have strong correlations with serum AMH or antral follicle counts, particularly in younger females, but the strength of the association appeared to increase with age. This result is likely attributed to high interindividual variation in primordial follicle activation and preantral follicle survival rates. Recent large studies in human populations have shown similar results but the primary limitation of these studies was that primordial follicle counts were determined from ovarian cortical biopsies, where regional variation in follicle distribution may affect the quality of the data. In the present study, whole ovaries were surveyed, eliminating this limitation. The findings indicate that primordial follicle counts are not closely related with either serum AMH or antral follicle counts in females in the early phase of the reproductive phase of life.
Art2 mediates selective endocytosis of methionine transporters during adaptation to sphingolipid depletion
Authors: Hepowit Nathaniel L. , Moon Bradley , Ebert Adam C. , Dickson Robert C. , MacGurn Jason A. 
Published: June 2023

ABSTRACT2
Accumulating evidence in several model organisms indicates that reduced sphingolipid biosynthesis promotes longevity, although underlying mechanisms remain unclear. In yeast, sphingolipid depletion induces a state resembling amino acid restriction, which we hypothesized might be due to altered stability of amino acid transporters at the plasma membrane. To test this, we measured surface abundance for a diverse panel of membrane proteins in the presence of myriocin, a sphingolipid biosynthesis inhibitor, in Saccharomyces cerevisiae. Unexpectedly, we found that surface levels of most proteins examined were either unaffected or increased during myriocin treatment, consistent with an observed decrease in bulk endocytosis. In contrast, sphingolipid depletion triggered selective endocytosis of the methionine transporter Mup1. Unlike methionine-induced Mup1 endocytosis, myriocin triggered Mup1 endocytosis that required the Rsp5 adaptor Art2, C-terminal lysine residues of Mup1 and the formation of K63-linked ubiquitin polymers. These findings reveal cellular adaptation to sphingolipid depletion by ubiquitin-mediated remodeling of nutrient transporter composition at the cell surface.
Public management reform under the dome of accruals (Presidential Decree 54/2018): Investigation of the effects on the financial information and the audit of the General Government entities
Authors: Goumas Spyridon , Karastogiannis Pavlos 
Published: June 2023

Presidential Decree 54/2018 legislated the introduction of accrual basis accounting from 1/1/2023 to all entities of the General Government of Greece in accordance with the European System of Accounts 2010. We study the effect of accrual basis accounting under the 54/2018 on financial information and audit of entities, as well as the transition process. The research was conducted using the qualitative method, the structured interview protocol was the data collection tool and the participants were the employees of the Third Department of the General Government Accounting Plan. We find that there will be objective information of the entity's financial position and performance, depreciation, provisions, impairments and fair value of assets. Transparency and accountability are strengthened, audits are facilitated to establish useful sound financial management, there is a central control of public finances and the phenomena of corruption and financing of public officials will be reduced. The job of the audit mechanisms is strengthened, audits become more effective and the way available resources are managed is more precisely controlled. Major difficulties during the transition are the lack of personnel and an appropriate accounting information system, and in combination with the covid-19 pandemic, it was noted that the transition cannot be implemented on 1/1/2023 and for that reason our results suggest an extension to 2025 for the transition, proposal which was implemented on July 30, 2022 with Law 4964/2022.

EL Classifications: H83, P41, M48.
Key words: Accrual Accounting, Accounting Reform, General Government, Accountability, Audit.
The Macroeconomic and Social imbalances in the Eurozone in the period of Economic Crisis (2008 - 2014)
Authors: Tamourantzis Asimakis 
Published: June 2023

This paper attempts to shed light on the economic and social effects of the economic crisis among Member States of the Eurozone in the period 2008-2014 emphasizing the imperative revision of the framework of the Stability and Growth Pact. Particular emphasis is given to the growing Macroeconomic and Social imbalances between Euro (€) North and Euro (€) South, which had posed a threat to the economic viability and social cohesion in the Eurozone.

JEL Classification: D63, E02, E60, E62, H30
Key words: Eurozone crisis, Economic Inequality, Macroeconomic Imbalances, Social Imbalances, Stability and Growth Pact
Proposal for an Information System of the Greek Tourism Satellite Account
Authors: Diakomihalis Mihail , Pappas Theodoros 
Published: June 2023

This paper gives a first look at the innovative Tourism Satellite Account (TSA) information system, which includes all the functions and procedures of updating the chain of TSA Tables, starting from data entry, storage and management of data, updating of TSA Tables, after the necessary statistical analysis, and finally the possibility of capturing the economic results of tourism activity in an economy.
The methodology applied allows the connection of the tables and the export of reliable and timely results. The proposed information system aims not only to improve the efficiency of tourism data management but also to facilitate their collection and ultimately the functionality and usefulness of TSAs.
The results expected from the proposed implementation will provide academics, professionals and tourism policy makers with new perspectives on the evaluation and improvement of tourism and on regional and national economic development (Wu, Liu, and Song, 2018). The TSA is integrated into the general information System of National Accounts (SNA).
The development of the Online Analytical Processing (OLAP) Tourism Satellite Account model, named “OLAP- TSA-Model”, for integrating the data from the SNA Tables after the necessary processing and consideration of tourism data sources in the TSA tables, their transition from one TSA table to the next, to seamlessly complete them and reveal the values of the economy attributed to the tourism activity of a country, are the subject of research of this paper.

Keywords: System of National Accounts, Tourism Satellite Account, Information System, Tourism, Greece.

Jel: E290, L830, O100, R150
Oficjalne wizyty państwowe w Toruniu w latach 1920-1939
Authors: Grzebieniak Anna 
Published: June 2023

W artykule opisano okoliczności oraz przebieg wizyt w Toruniu osób zajmujących najwyższe stanowiska we władzach państwowych i wojskowych odrodzonej Rzeczypospolitej. Przyjęte ramy czasowe obejmują okres od roku 1920, w którym wojsko polskie przejmuje Toruń z rąk niemieckich w konsekwencji postanowień traktatu wersalskiego, do wybuchu II wojny światowej w 1939 r. W opisie zdarzeń wykorzystano materiały z prasy ukazującej się w regionie oraz informacje pozyskane w trakcie studiów nad materiałami archiwalnymi pozyskanymi w trakcie kwerend odbytych w Archiwum Państwowym w Toruniu oraz Bydgoszczy.
¿Son los plazos de garantía un límite a la exigencia de durabilidad de un bien?
Authors: Isler Soto Érika 
Published: June 2023

El trabajo analiza comparativamente si es posible considerar que los plazos de extinción de las prerrogativas derivadas de las garantías de conformidad, excluyen otro estándar de durabilidad mayor. Al respecto se distinguen tres situaciones. Una primera solución prohíbe la obsolescencia programada. Otras legislaciones, sin sancionar la obsolescencia, contemplan otros deberes que trascienden el plazo de las garantías (repuestos, información). Finalmente, en una tercera situación, se omite una referencia explícita acerca de la vigencia de plazos mayores. No obstante, ello no excluye su procedencia, si se los derivan del principio de consumo sustentable o del interés general o público.
Rhabdomyosarcoma of the nasal cavity: a case report
Authors: Huang Meiying , Deng Bifan 
Published: June 2023

Introduction: Rhabdomyosarcoma is a high-grade malignant neoplasm with skeletal muscle differentiation; a common soft tissue sarcoma in children but considered one of the rarest in adults. Case description: We report a case of 35-year-old male with a chronic productive cough and haemoptysis for five days. A CT scan of the nasopharynx revealed a blocked left maxillary and ethmoid sinus with bone destruction. These findings raised a suspicion of a tumour, and trans-nasal endoscopic sinus surgery was performed. Discussion: Nasal rhabdomyosarcoma is a rare adult malignant tumour. Most patients have lymphatic metastasis or skull base tumour infiltration at the time of the initial diagnosis and treatment, which poses a challenge to the diagnosis and management. Conclusion: Nasal acinar rhabdomyosarcoma, one of the histopathological types of rhabdomyosarcoma, has rapid disease progression and high mortality. Therefore, the treatment of rhabdomyosarcoma requires a combination of surgery, chemotherapy, radiotherapy, and immunotherapy to work together to achieve the best care for the patient.
Investigation on low-loss hollow-core anti-resonant terahertz fiber
Authors: Li Lin , Lin Dongfeng , Meng Fanchao , Zhao Yiming , Cui Yiping , Cao Yin , Liu Hongwei , Mu Hongqian , Niu Yingli , He Jingwen , Liang Sheng 
Published: June 2023

In this work, a hollow-core anti-resonant terahertz (THz) fiber with elliptical cladding and nested tubes is proposed and fabricated. It is an effective way to reduce the loss of THz waves by transmitting them in an air core and breaking the material absorption. After parameter optimization of the initial structure, multiple transmission windows exist in the 0.2–0.8 THz band, where confinement loss is as low as 3.47×10−3cm−1 at 0.8 THz. At 0.2–0.7 THz, confinement losses lie between 10−3 and 10−2cm−1. The 3D printed samples are characterized by a THz time-domain spectroscopy system. Experimental results showed that the designed fiber structure transmits loss coefficients up to 10−2cm−1 in the 0.2–0.8 THz band (the minimum value is located at 0.46 THz, corresponding to a loss coefficient of 0.0284cm−1). The experiments show that the designed THz fiber achieves a good transmission effect.
Simulation study of an x-ray sub-picosecond resolution detection system based on time-domain amplification
Authors: Wang Gang , Liu Yiheng , Yan Xin , Gao Guilong , Wang Tao , Li Lili , Zhao Yuetong , Zhao Jinbo , He Kai , Tian Jinshou 
Published: June 2023

This study proposes what we believe to be a novel x-ray detection
system that achieves a temporal resolution of 930 fs with
photorefractive and four-wave mixing effects. The system comprises two
parts: a signal-conversion system and signal-acquisition system. The
signal-conversion system is based on the photorefractive effect, which
converts x-ray evolution into the variation of infrared interference
intensity. The signal-conversion sensor consists of ultra-fast
response LT-GaAs and a high-resolution interference cavity, achieving
a resolution of 767 fs. The signal-acquisition system
consists of a time-domain amplification system based on four-wave
mixing and a high-resolution signal-recording system with a resolution
of 21 ps, providing a temporal resolution of 525 fs.
Teaching Staff Attitude Towards Using Augmented Reality as a Pedagogical Tool During Covid 19 Pandemic Crisis Period
Authors: Alqahtani Ebtisam 
Published: June 2023

Advanced digital technology has given rise to modern visual tools known as Augmented Reality (AR). AR integrates virtual information into the real environment, and recent studies have demonstrated its potential to enhance teaching and learning practices in higher education. However, while university learners have become increasingly adept at utilizing technology to support their learning, many faculty members have been slower to embrace technology for enhancing their teaching practices. This study aims to investigate the attitudes of academic staff towards adopting Augmented Reality Technologies (ARTs) in higher education. Additionally, it seeks to determine whether there are any differences in attitudes based on age, utilizing the Technology Acceptance Model (TAM) as a theoretical framework. A survey was conducted, and a total of (851) usable responses were received from participants. The study results reveal that most faculty members have a positive attitude towards using AR as a pedagogical tool in teaching and learning, particularly to support students remotely during crisis periods. Additional results indicate that the response to crises factor strongly influences academic staff attitude towards AR. Moreover, the attitude factor strongly influences academic staff members' intention to use AR in the future. Additionally, the results show that there are no differences between the teaching staff and their age regarding their attitude. The paper concludes with some recommendations.
Vaginal metastasis from breast cancer: A case report
Authors: Yan Yunbo , Guo Tianjiao , Zhang Minmei , Cui Guozhong 
Published: June 2023

Abstract
Breast cancer is one of the most common malignancies in women. However, cases of vaginal metastases of breast cancer are rarely reported in China and abroad. The main clinical symptom of vaginal metastases of breast cancer is vaginal bleeding. This article aims to provide a reference for the diagnosis and clinical management of vaginal metastases from breast cancer. This article describes in detail the management of a 50-year-old woman with vaginal metastases from breast cancer, who was admitted to the hospital with persistent vaginal bleeding without apparent causes. Persistent vaginal bleeding was found after two and a half years when her breast cancer surgery was performed. After comprehensive evaluation, vaginal mass resection was performed. Postoperative histopathology confirmed that the vaginal mass was breast cancer metastasis. The patient was treated with local radiotherapy and three cycles of eribulin and bevacizumab after the vaginal mass was removed. A reexamination of computed tomography showed that the chest wall metastases were less extensive than before. Orbital metastases were also reduced in size, which was revealed by the physical examination. The patient had since failed to return to hospital on time for a regular treatment due to personal reasons. After 9 months of follow-up, the patient died of multiple metastases. The diagnosis of vaginal masses is based on pathological examination, and systemic treatment should be the mainstay when extensive metastases are presented.
Quasilinear class of noncoercive parabolic problems with Hardy potential and L1-data
Authors: Ahmedatt Taghi , Hajji Youssef , Hjiaj Hassane 
Published: June 2023

Abstract
In this article, we study the following noncoercive quasilinear parabolic problem

∂
u

∂
t

−

div

a

(

x
,
t
,
u
,

∇

u

)

+
ν

∣
u
∣

s
−
1

u
=
λ

∣
u
∣

p
−
2

u

∣
x
∣

p

+
f

in

Q

T

,

u
=
0

on

Σ

T

,

u

(

x
,
0

)

=

u

0

in

Ω
,

\left\{\begin{array}{ll}\frac{\partial u}{\partial t}-\hspace{0.1em}\text{div}\hspace{0.1em}a\left(x,t,u,\nabla u)+\nu {| u| }^{s-1}u=\lambda \frac{{| u| }^{p-2}u}{{| x| }^{p}}+f& \hspace{0.1em}\text{in}\hspace{0.1em}\hspace{0.33em}{Q}_{T},\\ u=0& \hspace{0.1em}\text{on}\hspace{0.1em}\hspace{0.33em}{\Sigma }_{T},\\ u\left(x,0)={u}_{0}& \hspace{0.1em}\text{in}\hspace{0.1em}\hspace{0.33em}\Omega ,\end{array}\right.

with

f
∈

L

1

(

Q

T

)

f\in {L}^{1}\left({Q}_{T})

and

u

0

∈

L

1

(

Ω

)

{u}_{0}\in {L}^{1}\left(\Omega )

and show the existence of entropy solutions for this noncoercive parabolic problem with Hardy potential and L1-data.
Evaluation of pyruvate kinase and oxidative stress parameters in differentiation between transudate and exudate in pleural liquids
Authors: Dumanlı Ahmet , Günay Ersin , Aydın Suphi , Çilekar Şule , Gencer Adem , Kurbaseviç Emira , Öz Gürhan , Çelik Sefa , Balcı Aydın , Özcan Mehmet , Karadağ Müjgan Ercan 
Published: June 2023

Abstract

Objectives
We aimed to investigate the usability of pleural pyruvate kinase (PK), total antioxidant status (TAS), and total oxidant status (TOS) as an alternative to Light’s criteria in exudate-transudate differentiation.

Methods
This prospective study was conducted among 84 patients (42 transudates and 42 exudates) with pleural effusion. The levels of PK, TAS, and TOS were measured by using ELISA kits, and the ROC analysis was used to evaluate the diagnostic efficiency.

Results
PK (p=0.001), TAS (p=0.027), and TOS (p=0.002) levels in pleural fluids were found to be significantly higher in the exudate group. The cut-off values for PK, TAS, and TOS were 10.64 U/L, 13.54 mmol trolox equivalent/L, and 13.88 μmol H2O2 equivalent/L, respectively. While the sensitivity values were 97.62 % for PK, 66.67 % for TAS, and 64.29 % for TOS, the specificity values were 80.95 % for PK, 52.38 % for TAS, and 57.14 % for TOS.

Conclusions
PK levels in pleural effusion can be useful in suspected cases to differentiate between exudate and transudate in addition to Light’s criteria. However, pleural TOS and TAS parameters could not be as sensitive and specific as Light’s criteria.
The clinical characteristics of acute cerebral infarction patients with thalassemia in a tropic area in China
Authors: Liu Liyuan , Ben Xinyu , Li Chang , Liu Jiaqi , Ma Lin , Liao Xiaoping , Zou Qin , Li Qifu 
Published: June 2023

Abstract
This study aimed to explore the clinical characteristics of acute cerebral infarction (ACI) patients with thalassemia through the analysis of clinical data. Adult patients with ACI who were admitted to the First Affiliated Hospital of Hainan Medical College, the Second Affiliated Hospital of Hainan Medical College, Hainan Provincial People’s Hospital, and the Department of Neurology of Haikou People’s Hospital from January 2008 to December 2018 were enrolled. According to the eligibility criteria, 183 ACI patients were examined, of whom there were 33 cases with thalassemia, 50 cases with iron-deficiency anemia (IDA), and 100 non-anemic cases. Laboratory data, including platelet count, homocysteine count, and hemoglobin level, were collected. Besides, the results of auxiliary examinations, such as brain magnetic resonance imaging or computed tomography, carotid ultrasound, electrocardiogram, and cardiac color ultrasound, were collected. Baseline clinical data (e.g., history of smoking and drinking) were acquired. The clinical characteristics were compared and analyzed among the three groups. There were more female ACI patients with thalassemia than male ones. Furthermore, lesions in the thalassemia and IDA groups were mainly located in the region from the corona radiata and the centrum semiovale, in which multiple small infarcts were dominant. In the non-anemia group, patients’ lesions were mainly found in the basal ganglia area, and single small infarcts had the highest proportion.
Sprachdatenbasierte Modellierung von Wissensnetzen in der mittelalterlichen Romania (ALMA): Projektskizze
Authors: Prifti Elton , Schweickard Wolfgang , Selig Maria , Tittel Sabine 
Published: June 2023

Abstract
We present ALMA, a new research project aimed at investigating the interaction between language and knowledge practices from AD 1100 to 1500. Our primary question is how Medieval Italian, French, Occitan, Catalan, and Spanish developed into languages of knowledge and scholarship (German Wissen(schafts)sprachen) in permanent opposition to and exchange with the predominant Latin (but also with Arab, Greek, and Hebrew). Focusing on two domains, medicine and law, the project combines linguistics, text philology, and the history of science with the Digital Humanities and ontology engineering. ALMA will create two multi-lingual, domain-specific text corpora by integrating text editions of hitherto unedited manuscripts and incunabula, and digitized printed editions. Our corpus-linguistic exploration of the ALMA corpora will provide the basis for lexical-semantic studies that analyze emerging knowledge networks and the depth of their linguistic representations. We hypothesize that language evolution and the development of more complex linguistic structures will allow for measuring the impact of knowledge practices on medieval vernacular languages. We will trace the dissemination of lexical material across languages, language varieties, cultural spaces, and periods. This will enable us to follow specific vernacular communication channels. We will use cutting-edge technologies to compile, publish, and share our findings, and to model them in the form of historicized ontologies and Linked Data. Our onomasiological, ontology-driven approach will result in the creation of domain models that can be re-used within the Semantic Web. This has great potential to be relevant for researchers from different disciplines.