bluuebunny/crossref_metadata_2025_split huggingface dataset:
Research on the Mechanism of Humic Acid Effect on the Strength of Cement-cured Dredged Sludge
Authors: Gong Shunmei , Feng Songbao , Wang Shiquan , Duan Limin , Niu Zhiyong , Xu Qiang , Zhang Qigui , Chen Yuanyuan 
Published: August 2023

Abstract
As an essential component of sludge, soil organic matter is also the most energetic component of the sludge solid phase. However, the organic content of sludge reduces the engineering qualities of cement-cured sludge and restricts the cement curing reaction process. Humic acid (HA) was employed in tests conducted indoors to mimic the organic material naturally present in the waste sludge. The effect of different HA and cement dosages was investigated for the strength of the dredged sludge. The mechanism of the effect of HA on the strength of cement-solidified dredged sludge (CDS) was examined in conjunction with the findings of unconfined compression strength (UCS), scanning electron microscopy (SEM), and X-ray diffraction (XRD). (1)The overall unconfined compressive strength of CDS decreased after the addition of HA. (2) The strength of the HA sludge-cured body exhibits an increasing trend with the increase in cement input. The strength of sludge cured bodies with high HA content can be enhanced by correctly increasing the curing agent. (3) HA acts as a cement retarder, delaying hydration time by adhering to the surface of cement particles to form an adsorption coating. (4) As observed by SEM, the conversion of C-S-H to foil-like is hindered by HA in the silt, and its microscopic morphology changes with the change of HA content, which is manifested by the decrease of CDS intensity on a macroscopic scale.
A tumor microenvironment-based classification of gastric cancer for more effective diagnosis and treatment
Authors: Duda Dan , Dima Simona , Sorop Andrei , Kitahara Shuji , Setia Namrata , Chivu-Economescu Mihaela , Matei Lilia , Herlea Vlad , Pechianu Nicolae , Inomata Takenori , Matsui Aya , Khachatryan Anna , Aoki Shuichi , Lauwers Gregory , Popescu Irinel 
Published: August 2023

Abstract
With approximately one million diagnosed cases and over 700,000 deaths recorded annually, gastric cancer (GC) is the third most common cause of cancer-related deaths worldwide. GC is a heterogeneous tumor. Thus, optimal management requires biomarkers of prognosis, treatment selection, and treatment response. The Cancer Genome Atlas program sub-classified GC into molecular subtypes, providing a framework for treatment personalization using traditional chemotherapies or biologics. Here, we report a comprehensive study of GC vascular and immune tumor microenvironment (TME)-based on stage and molecular subtypes of the disease and their correlation with outcomes. Using tissues and blood circulating biomarkers and a molecular classification, we identified cancer cell and tumor archetypes, which show that the TME evolves with the disease stage and is a major determinant of prognosis. Moreover, our TME-based subtyping strategy allowed the identification of archetype-specific prognostic biomarkers such as CDH1-mutant GC and circulating IL-6 that provided information beyond and independent of TMN staging, MSI status, and consensus molecular subtyping. The results show that integrating molecular subtyping with TME-specific biomarkers could contribute to improved patient prognostication and may provide a basis for treatment stratification, including for contemporary anti-angiogenesis and immunotherapy approaches.
Oral supplementation with melengestrol acetate incorporated in protein-energy blocks II- effect on pregnancy rates of Nellore cows submitted to FTAI and FTET.
Authors: Nogueira Eriklis , Neves Thiago Vieira , Silva Juliana Correa Borges , Vaz Francisco Eduardo Machado , Silva Lucas Gomes da , Oliveira Luiz Orcirio Fialho , Mingoti Gisele Zoccal 
Published: August 2023

Abstract
The study aimed to evaluate the use of Melengestrol acetate (MGA) supplementation in protein-energy blocks on pregnancy rate post-FTAI or post-FTET for multiparous Nellore cows. In trial 1, 863 cows were submitted to FTAI following P4-estradiol protocol. After FTAI, the animals were allocated into three groups: control (n = 301): supplemented with nutritional blocks; MGA13-18 (n = 309): supplementation with same nutritional block added with MGA between the 13th and 18th days after FTAI; MGA6-18 (n = 253): supplementation with same nutritional block added with MGA between the 6th to 18th days after FTAI. In the second trial, 310 embryo recipients’ cows were submitted to the same estrus synchronization protocol and in vitro-produced embryos were transferred 7 days after the estimated estrus day (D0), and divided into two groups: control (n = 149): supplemented with nutritional blocks without the addition of MGA; MGA group (n = 161): supplemented with nutritional blocks added with MGA between 13th and 18th days after D0. In trial 1, the P/AI were similar for MGA13-18 (56.6%: 175/309) and MGA6-18 (57.70%: 146/253) groups, which were higher (P = 0.0273) than the Control (48.5%: 146/301). In trial 2, pregnancy rates weren´t influenced by treatments [Control: 49.33% (74/149); MGA: 54.37% (87/161); P = 0.185]. In conclusion, supplementation with MGA incorporated into nutritional blocks improves P/AI, proving to be a hormonal tool capable of increasing reproductive efficiency in cattle without major changes in animal supplementation management. The supply of MGA after FTET to recipient cows did not increase pregnancy rates.
Childhood Traumatic Cataract in Nigeria; A Multicenter Study: 2017-2021
Authors: Ademola-Popoola Dupe , Muhammad Nasiru , Mayor Atima , Wade Patricia , Ezegwui Ifeoma , Musa Kareem , Ugalahi Mary , Nkanga Elizabeth Dennis , Udeh Nnenma , Ezisi Chinyelu , Okeigbemen Valentina , Dawodu Oseluese , Panshak Tenmang , Okanya Chinenyenwa , Etiowo Nkama , Sule Ademola , Obajolowo Tokunbo , Olusanya Bolutife , Muhammad Hassan 
Published: August 2023

Abstract
Objective: To determine the frequency, demography, etiology and mechanisms of ocular injuries associated with childhood traumatic cataract in Nigeria
Methods: A retrospective multicenter study conducted across ten child eye health tertiary facilities in Nigeria between January 2017 and December 2021. Clinic records of all children aged 0-17 years who had been diagnosed with cataract at the various participating centers were reviewed. Information collected include: biodata, mechanism of injury; laterality, place of injury; object responsible; person responsible; duration before presentation and surgical intervention.
Results: A total of 636 out of 1656 children (38.4%) had traumatic cataracts during the study period. Their mean age was 109.4 ± 45.2 months with a male to female ratio of 2:1. Most injuries were unilateral, two (0.3%) children had bilateral involvement. Only 78(15.3%) children presented within 4 weeks of the injury. Closed globe injuries were responsible for the traumatic cataract in 475(74.7%) children, while open globe injuries were more likely to present within 24 hours (P <0.001). The commonest objects of injury were cane, sticks, plant, wood and play materials. Self-inflicted injuries occurred in about 82(13%) children while 407(64.0%) were caused by close relatives and contacts. The location where trauma occurred was home in 375(59.8%) and school in 107(16.8%) children.
Conclusion: This multicenter study demonstrates that more than one-third of all childhood cataracts in Nigeria are trauma-related and majority are due to closed globe injuries. Public health interventions to reduce the occurrence of ocular trauma and to encourage early presentation after trauma are advocated.
Creativity in undergraduate medical education: Teaching activities during student groups’ idea evaluation process
Authors: Broekhoven Kim van , Uum Martina van , Meijer Paulien , Kroesbergen Evelyn H. , Huck Jojanneke 
Published: August 2023

Abstract
Background: Creativity should be cultivated in medical education to tackle the increasingly complex problems in the medical world; however, despite this need for novelty, students collaborating in groups to solve a medical problem often seek consensus around low-novelty ideas. This study aims to explore the challenges medical student groups face while evaluating and improving creative ideas, and to identify teaching activities that overcome these challenges.
Methods: A qualitative study was conducted using semi-structured interviews with 14 teachers from the ‘innovation project’ at Radboud university medical centre in the Netherlands.
Results: Student groups face challenges in balancing the goals of novelty and usefulness in their search for creative ideas, often selecting either novel ideas that are infeasible or ineffective, or useful ideas that already exist. Furthermore, teachers also identified problematic group dynamics as a challenge in the idea evaluation process. To overcome these challenges, teachers reported using cognitive, affective, metacognitive, and socio-communicative teaching activities.
Conclusions: Medical students may not develop their most creative ideas even when creative solutions are required in the medical context. This study highlights the importance of teaching medical students to skilfully manage the twin goals of novelty and usefulness in their search for creative solutions, while also dealing with group dynamics.
Raynaud’s phenomenon on initiation of Lithium therapy: A Case Report.
Authors: Boland Cailin , Adams Emma , Wong Man Ching , Denihan Cian 
Published: August 2023

Abstract

Lithium Carbonate is an effective treatment for affective disorders, but has a range of side effects. This case report highlights a rare side effect of Raynaud’s phenomenon following initiation of Lithium therapy in a patient with recurrent depressive disorder. He was commenced on Lithium therapy to treat severe treatment resistant depression with psychotic symptoms when alternative treatments trialled were ineffective. He had no other risk factors or known aetiological causes for development of Raynaud’s phenomenon. Symptoms resolved on discontinuation of Lithium and re-emerged on recommencement. Previous case series have shown Lithium effectively treating vasospastic disorders such as cluster headache and Raynaud’s phenomenon. However, a paradoxical reaction to those previously described was induced in this case.
Economic impact of antagonist protocol vs primed progesterone protocol in oocyte donor program A retrospective study
Authors: GONZALO JOSEP , Castelo-Branco Camil , garcia sandra , Devesa Marta , Polyzos Nikolaos 
Published: August 2023

Abstract
Objective: To assess the cost-effectiveness of two ovarian stimulation procedures comparing the use of FSH antagonists with the use of FSH primed progesterone protocol in a oocyte donor program.
Design: Calculation of cost-effectiveness ratios (costs per outcome achieved) from clinical practices using a retrospective cohort single university center study carried out from 2012 to 2021.
Main Outcome Measure(s): Cost-effectiveness ratios as cost per mature oocyte and cost per treatment.
Result(s): According to the economic analysis, ovarian stimulation with FSH antagonist protocol increased the overall cost of the treatment as well as the cost per retrieved and effective oocyte. The cost of gonadotrophins per mature oocyte retrieved was 49.27 ± 17.94 € and the cost of medication per mature oocyte retrieved was 59.26± 28.01 € . In the FSH primed progesterone group, the cost of gonadotrophins per mature oocyte retrieved was 44.67 ± 16.65€ and the cost of medication per mature oocyte retrieved was 44.91 ± 20.86€
Conclusion(s): Cost-effectiveness is a compelling reason for an egg donation program. Progestins can present an effective and less expensive option for egg donation programs in terms of cost.
Association of Physical Activity and Vitamin D Deficiency with Cognitive Impairment in Older Adults: A Population Based Cross-sectional Analysis from NHANES 2011-14
Authors: Guo Jing , Mo Hongfei , Zuo Longfei , Liang Rui , Lyu Quanjun 
Published: August 2023

Abstract
Objectives
The global aging situation is becoming increasingly critical and cognitive impairment in the elderly has become a public health burden of concern. Physical activity (PA) and vitamin D may play a key role in improving cognitive impairment. However, little studies have examined the interaction between these two. The purpose of this study was to assess the association of PA and vitamin D with cognitive impairment in older adults, as well as the interactions of PA and vitamin D.
Materials and Methods
This study was conducted by multi-stage random sampling of elderly people ≥ 60 years old, and a total sample of 2492 (1207 males and 1285 females, mean age of 69.41 ± 6.75 years) with complete data was included in the analysis. PA was assessed by the Global Physical Activity Questionnaire, and < 600 MET-min/wk was used as the division criteria. Serum vitamin D was measured by high-performance liquid chromatography tandem mass spectrometry, and 25-hydroxyvitamin D2/D3 concentration < 20 ng/ml was used as a vitamin D deficiency criterion. Cognitive function was assessed by three subtests: the Consortium to Establish a Registry for Alzheimer’s disease word learning test (CERAD-WL) for immediate and delayed learning, the Animal Fluency Test (AFT) for verbal fluency; and the Digit Symbol Substitution Test (DDST) for information processing speed and switching attention. All three subtests were scored at less than the lowest quartile of the score as a criterion for cognitive impairment. Statistical analysis was performed using SPSS for chi-square test, rank sum test, interaction analysis, subgroup analysis and regression analysis.
Results
Lower level of PA is associated with higher odds of cognitive impairment. (CERAD W-L: OR = 1.596, 95% CI: 1.338–1.905, P < 0.001; AFT: OR = 1.833, 95% CI: 1.534–2.190, P < 0.001; DDST: OR = 1.936, 95% CI: 1.609–2.329, P < 0.001). Vitamin D deficiency has significant effects in AFT (OR = 1.322, 95% CI: 1.103–1.584, P = 0.003) and DDST (OR = 1.619, 95% CI: 1.345–1.948, P < 0.001). After adjusted for covariates, PA and vitamin D have multiplicative interaction on AFT (OR = 0.662, 95% CI: 0.448–0.977, P = 0.038) and DDST (OR = 0.775, 95% CI: 0.363–0.868, P = 0.009). The interaction between PA and vitamin D was not significant in the CERAD W-L (OR = 0.757, 95% CI: 0.508–1.128, P = 0.172).
Conclusions
The results showed that lower level of PA and vitamin D deficiency were associated with higher odds of cognitive impairment in the elderly population and that there was a multiplicative interaction between PA and vitamin D on cognitive function, with a significant effect of vitamin D on cognitive impairment in high PA conditions.
Quantitative gait analysis and prediction usingartificial intelligence for patients with gait disorders
Authors: Chaabane Nawel Ben , Conze Pierre-Henri , Lempereur Mathieu , Quellec Gwenolé , Rémy-Néris Olivier , Brochard Sylvain , Cochener Béatrice , Lamard Mathieu 
Published: August 2023

Abstract
Quantitative Gait Analysis (QGA) is considered as an objective measure of gait performance. In this study, we aim at designingan artificial intelligence that can efficiently predict the progression of gait quality using kinematic data obtained from QGA. Forthis purpose, a gait database collected from 734 patients with gait disorders is used. As the patient walks, kinematic data iscollected during the gait session. This data is processed to generate the Gait Profile Score (GPS) for each gait cycle. Trackingpotential GPS variations enables detecting changes in gait quality. In this regard, our work is driven by predicting such futurevariations. Two approaches were considered: signal-based and image-based. The signal-based one uses raw gait cycles,while the image-based one employs a two-dimensional Fast Fourier Transform (2D FFT) representation of gait cycles. Severalarchitectures were developed, and the obtained Area Under the Curve (AUC) was above 0.72 for both approaches. To the bestof our knowledge, our study is the first to apply neural networks for gait prediction tasks.
Whole genome sequencing provides evidence for Bacillus velezensis SH-1471 as a beneficial rhizosphere bacterium in plants
Authors: Shen Yunxin , Shi Zhufeng , Zhao Jiangyuan , Li Minggang , Wang Nan , Mo Yanfang , Yang Tongyu , Tang Jiacai , Zhou Xudong , Chen Qibin , Yang Peiweng 
Published: August 2023

Abstract
Bacillus spp. is widely used in agriculture due to its diverse biological activities. We isolated a Bacillus velezensis SH-1471 from the rhizosphere soil of healthy tobacco, which has broad-spectrum antagonistic activity against a variety of plant pathogenic fungi such as Fusarium oxysporum, and can be colonized in the rhizosphere of a variety of plants. This study will further explore its mechanism by combining biological and molecular biology methods. B. velezensis SH-1471 contains a ring chromosome of 4181346 bp with a mean G+C content of 46.18%. We identified 14 homologous genes related to biosynthesis of resistant secondary metabolite, and three clusters encoded potential new antibacterial substances. It also contains a large number of genes from colonizing bacteria and genes related to plant bacterial interactions. It also contains genes related to environmental stress, as well as genes related to drug resistance. In addition, we found that there are many metabolites in the strain that can inhibit the growth of pathogens. Therefore, B. velezensis SH-1471 is a potential biological control strain with important application value. The results of this study will help to further study the mechanism of B. velezensis SH-1471 in biological control of plant diseases and promote its application.
Obesity-induced PARIS (ZNF746) accumulation in adipose progenitor cells leads to attenuated mitochondrial biogenesis and impaired adipogenesis
Authors: Hachiya Kazuki , Deguchi Yusuke , Hirata Takuro , Arikawa Tomoya , Fukai Hiroto , Esashi Tatsuhiro , Nagasawa Kota , Mizunoe Yuhei , Nozaki Yuka , Kobayashi Masaki , Higami Yoshikazu 
Published: August 2023

Abstract
White adipose tissue (WAT) is critical for whole-body energy metabolism, and its dysfunction leads to various metabolic disorders. In recent years, many studies have suggested that impaired mitochondria may contribute to the obesity-related decline in adipose tissue function, but the detailed mechanisms remain unclear. To investigate these mechanisms, we carried out a comprehensive analysis of WAT from mice with diet-induced obesity. The transcription factor Parkin interactive substrate (PARIS or ZNF746), which suppresses the expression of peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α), a key regulator of mitochondrial biogenesis, was found to be accumulated in adipose progenitor cells from obese mice. Furthermore, we demonstrated that 3T3-L1 preadipocytes with overexpression of PARIS protein exhibited decreased mitochondrial biogenesis and impaired adipogenesis. Our results suggest that the accumulation of PARIS protein may be a novel component of the pathogenesis of obesity-related dysfunction in WAT.
Volatile aroma and physicochemical characteristics of freeze-dried coconut water using different encapsulating agents
Authors: Tanongkankit Yardfon , Eadmusik Sunee , Detchewa Pakkawat , Budsabun Tanakwan , Panphut Wattana , Jakkranuhwat Nattakan , Rittisak Sriwiang , Nonthanum Panadda , Phungamngoen Chanthima 
Published: August 2023

Abstract

This research studied how different types and concentrations of encapsulating agents impacted freeze-dried coconut water products. Volatile aroma and physicochemical product characteristics were evaluated. The encapsulating agents were maltodextrin 4–8% (w/v), polydextrose 4–8% (w/v) and xanthan gum 0.1–0.3% (w/v). A plate freezer and an air blast freezer were used to pre-freeze the coconut water before drying. Freezing time had no impact on moisture content and water activity. The flavor of coconut water is composed of alkanes, aldehyde, ketones, organic acids and some other flavor substances. Encapsulating agents are the main factors affecting the flavor of coconut water. Optimal conditions for producing dried coconut water were adding polydextrose at a concentration of 8%. Volatile compounds were assessed under different conditions of SPME-GC-MS. The composition of flavor compounds in coconut water is complex and mainly includes esters, aldehydes, and phenols. Results showed that encapsulating agents improved the volatile aroma of dried coconut water products.
Accurate determination of the magnetic axis of a solenoid using measured field data and understanding the beam dynamics
Authors: sinha gautam , Malik Ritesh 
Published: August 2023

Abstract

Fundamental understanding of both the theory and the measurement procedure of a solenoid is the key to execute the project cost effectively and to achieve the desired performance. Attempt is made to understand the beam dynamic of charge particles by considering the conservation of canonical angular momentum of non-zero values. Analytical expression to generate a parallel beam using solenoid is derived. Effect of final beam size on the values of spherical aberration coefficient and focal length of a solenoid is studied using electron trajectories. Practical procedure to tune the above two parameters of a solenoid by simple modification is demonstrated. Mathematical model is derived to accurately determine the axis of a solenoid and the magnetic centre using measured magnetic field data and experimentally demonstrated the validity of the theory. Several solenoids are characterised using the procedure and used in the 9.5 MeV 10 kW electron LINAC which is appropriate for the use of sterilization of medical products and food irradiation.
Association between Total Genotype Score and Muscle Injuries in Top-level Football Players: a pilot study
Authors: Massidda Myosotis , Flore Laura , Cugia Paolo , Piras Francesco , Scorcu Marco , Kikuchi Naoki , Cięszczyk Pawel , Maciejewska-Skrendo Agnieszka , Tocco Filippo , Calò Carla Maria 
Published: August 2023

Abstract
Background. Recently, genetic predisposition to injury has become a popular area of research and the association between a few Single Nucleotide Polymorphisms (SNPs) and the susceptibility to develop musculoskeletal injuries has been shown. This pilot study aimed to investigate the combined effect of common gene polymorphisms previously associated with muscle injuries in Italian soccer players. Results. A total of 64 Italian top soccer players (age 23.1 ± 5.5 years; height 179.3 ± 7.3 cm; weight 73.0 ± 7.9 kg) were genotyped for 4 gene polymorphisms (ACE I/D rs 4341, ACTN-3 R/X rs 1815739, COL5A1 C/T rs 12722, MCT1 A/T rs1049434). Muscle injuries were gathered for 10 years (2009–2019). Buccal swabs were used to obtain genomic DNA, and the PCR method was used to genotype the samples. Logistic regression analyses showed a significant association of all four polymorphisms with muscle injury incidence (P < 0.01), while ACTN3 and COL5A1 polymorphisms were also significantly associated with injury severity (P = 0.042 and P = 0.012, respectively). In addition, the mean total genotype score (TGS) was significantly higher in injured than in non-injured (control) soccer players (injured: 57.5 ± 15.5 vs. non-injured: 36.6 ± 13.7, t = 6.33, P < 0.001) and this was a strong predictor of muscle injury (OR = 2.93, 95% CI: 0.06–0.18, P > 0.001). Conclusions. These data suggest that carrying a high number of "protective" gene variants could influence an individual's susceptibility to developing muscle injuries in soccer. Adapting the training load parameters to the athletes’ genetic profile represents today the new frontier of the methodology of training.