bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative study on the degradation of phenol by a high-voltage pulsed discharge above a liquid surface and under a liquid surface
Authors: ZHAO Quanfa , WU Haixia , SHEN Wang , HAN Xiao , ZHENG Bin , FAN Jiawei 
Published: April 2023

Abstract
The degradation of phenol by pulsed discharge plasma above a liquid surface (APDP) and under a liquid surface (UPDP) was compared. The effects of discharge voltage, discharge distance, initial solution conductivity and initial pH on the removal of phenol were studied. It was concluded that the removal of phenol increases with increasing discharge voltage and with decreasing discharge distance in both APDP and UPDP systems. An increase in the initial solution’s conductivity has a positive effect in the APDP system but a negative effect in the UPDP system. In addition, alkaline conditions are conducive to the degradation of phenol in the APDP system, while acidic conditions are conducive in the UPDP system. Free radical quenching experiments revealed that ·O−
2 has an important influence on the degradation of phenol in the APDP system, while ·OH plays a key role in the UPDP system. This paper verifies the differences in the two discharge methods in terms of phenol removal.
Probability of continued local-scale warming and extreme events during and after decarbonization
Authors: Diffenbaugh Noah S , Barnes Elizabeth A , Keys Patrick W 
Published: April 2023

Abstract
Although achieving net-zero emissions is very likely to stabilize the long-term global temperature, the possibility of continued warming and extreme events could cause those efforts to be perceived as a failure if there is an expectation that stabilizing global temperature will also stabilize local and regional climate. Leveraging decarbonization scenarios from multiple global climate models, we find that much of the world faces >30% probability of decadal warming after net-zero CO2 emissions are achieved, with most areas exhibiting sustained probability of extreme hot and wet events. Further, substantial fractions of the global population and gross domestic product could experience post-net-zero warming, including hundreds of millions of people and trillions of dollars in the United States, China and India during the decade following net-zero. This likelihood suggests that some of the most populous, wealthy, and powerful regions may experience climatic conditions that could be perceived—at least in the near-term—to indicate that climate stabilization policies have failed, highlighting the importance of adaptation for ensuring that communities are prepared for the climate variations that will inevitably occur during and after decarbonization.
Origin, importance, and predictive limits of internal climate variability
Authors: Lehner Flavio , Deser Clara 
Published: April 2023

Abstract
Adaptation to climate change has now become a necessity for many regions. Yet, adaptation planning at regional scales over the next few decades is challenging given the contingencies originating from a combination of different sources of climate projection uncertainty, chief among them internal variability. Here, we review the causes and consequences of internal climate variability, how it can be quantified and accounted for in uncertainty assessments, and what research questions remain most pertinent to better understand its predictive limits and consequences for science and society. This perspective argues for putting internal variability into the spotlight of climate adaptation science and intensifying collaborations between the climate modeling and application communities.
The Perceived Stress Scale as a Measure of Stress: Decomposing Score Variance in Longitudinal Behavioral Medicine Studies
Authors: Harris Kristie M , Gaffey Allison E , Schwartz Joseph E , Krantz David S , Burg Matthew M 
Published: April 2023

Abstract

Background
The Perceived Stress Scale (PSS) is a widely used measure designed to assess perceptions of recent stress. However, it is unclear to what extent the construct assessed by the PSS represents factors that are stable versus variable within individuals, and how these components might vary over time.

Purpose
Determine the degree to which variability in repeated PSS assessments is attributable to between-person versus within-person variance in two different studies and populations.

Methods
Secondary analyses utilized data from two studies with up to 13 PSS assessments: An observational study of 127 patients with heart failure followed over 39 months (Study 1), and an experimental study of 73 younger, healthy adults followed over 12 months (Study 2). Multilevel linear mixed modeling was used to estimate sources of variance in the PSS total and subscale scores across assessments.

Results
Between-person variance accounted for a large proportion of the total variance in PSS total scores in Study 1 (42.3%) and Study 2 (51.1%); within-person variance comprised the remainder. Between-person variance was higher for shorter assessment periods (e.g., 1 week), and was comparable when examining only the first 12 months of assessments in each study (52.9% vs. 51.1%).

Conclusions
Within two samples differing in age and health status, between-person variance accounted for approximately half of the total variation in PSS scores over time. While within-person variance was observed, the construct assessed by the PSS may substantially reflect a more stable characteristic of how an individual perceives stressful life circumstances than previously appreciated.
Association Between Body Mass Index and Nonspecific Recurrent Low Back Pain in Over 600,000 Healthy Young Adults
Authors: Nitecki Maya , Shapiro Galina , Orr Omri , Levitin Ehud , Sharshevsky Hadasa , Tzur Dorit , Twig Gilad , Shapira Shachar 
Published: April 2023

Abstract
An association between body mass index (BMI; weight (kg)/height (m)2) and low back pain (LBP) has long been debated, but inconsistent measurements of BMI and varying definitions of LBP have produced conflicting findings. We explored this association using measured BMI and physician documentation of recurrent LBP among healthy young adults. Data were extracted from the Israel Defense Forces electronic medical record system. All Israeli citizens with compulsory military service during January 2008–March 2019 were included (n = 705,840). Exclusion criteria were spine deformities, disc pathologies, spinal surgeries, arthropathies, connective tissue diseases, pain syndromes, low bone density disorders, cancers, and psychiatric illnesses. LBP was defined as electronic medical record system documentation of 1) 2 medical visits at least 6 weeks apart with a diagnosis of LBP or “LBP with radiation” or 2) 1 medical visit resulting in referral to an orthopedic surgeon. Logistic regression models were used to explore the association between BMI category and LBP; 619,969 (87.8%) individuals (mean age = 18.9 (standard deviation, 0.97) years; 56.9% male) were included. LBP prevalence was 9.2% (n = 56,918) and higher among males (9.7%) than females (8.5%). Overweight (odds ratio = 1.123, 95% confidence interval: 1.096, 1.151) and obesity (odds ratio = 1.137, 95% confidence interval: 1.096, 1.179) were associated with LBP. The association remained significant after accounting for various sociodemographic factors. Maintaining a healthy BMI may aid in the prevention of LBP in young adults.
Bias Due to Within-Subject Exposure Dependency With or Without Bias Due to Lack of Pairwise Exchangeability When Exposure Is Chronic in Case-Crossover and Case–Time-Control Studies: A Simulation Study
Authors: Kubota Kiyoshi , Kelly Thu-Lan 
Published: April 2023

Abstract
The case-crossover study design has been proposed as a suitable design for use when a brief exposure causes a transient change in risk of an acute-onset disease. In pharmacoepidemiology, the condition of “brief exposure” is rarely satisfied because medication use is often chronic or successive, which may result in bias due to within-subject exposure dependency. Here we describe a simulation of a case-crossover study conducted within a cohort, where patients successively used a drug for 60 or more days and the rate ratio for the outcome occurrence was 4.0. Standard conditional logistic regression for the analysis produced overestimated odds ratios ranging up to 7.8. This bias due to within-subject exposure dependency from chronic use can be removed by the Mantel-Haenszel method or by our recently proposed weighting method. We also show that when some patients are censored after switching to another drug, a lack of pairwise exchangeability causes bias which is similar to bias due to an exposure time trend. This bias can be removed by using the case–time-control study design. We show that bias due to within-subject exposure dependency and lack of pairwise exchangeability occur independently and can occur separately or simultaneously, and we demonstrate how to detect and remove them.
Bumetanide induces post-traumatic microglia–interneuron contact to promote neurogenesis and recovery
Authors: Tessier Marine , Garcia Marta Saez , Goubert Emmanuelle , Blasco Edith , Consumi Amandine , Dehapiot Benoit , Tian Li , Molinari Florence , Laurin Jerome , Guillemot François , Hübner Christian A , Pellegrino Christophe , Rivera Claudio 
Published: April 2023

Abstract
Although the Na-K-Cl cotransporter (NKCC1) inhibitor bumetanide has prominent positive effects on the pathophysiology of many neurological disorders, the mechanism of action is obscure. Attention paid to elucidating the role of Nkcc1 has mainly been focused on neurons, but recent single cell mRNA sequencing analysis has demonstrated that the major cellular populations expressing NKCC1 in the cortex are non-neuronal.
We used a combination of conditional transgenic animals, in vivo electrophysiology, two-photon imaging, cognitive behavioural tests and flow cytometry to investigate the role of Nkcc1 inhibition by bumetanide in a mouse model of controlled cortical impact (CCI).
Here, we found that bumetanide rescues parvalbumin-positive interneurons by increasing interneuron-microglia contacts shortly after injury. The longitudinal phenotypic changes in microglia were significantly modified by bumetanide, including an increase in the expression of microglial-derived BDNF. These effects were accompanied by the prevention of CCI-induced decrease in hippocampal neurogenesis. Treatment with bumetanide during the first week post-CCI resulted in significant recovery of working and episodic memory as well as changes in theta band oscillations 1 month later.
These results disclose a novel mechanism for the neuroprotective action of bumetanide mediated by an acceleration of microglial activation dynamics that leads to an increase in parvalbumin interneuron survival following CCI, possibly resulting from increased microglial BDNF expression and contact with interneurons. Salvage of interneurons may normalize ambient GABA, resulting in the preservation of adult neurogenesis processes as well as contributing to bumetanide-mediated improvement of cognitive performance.
Epsin2, a novel target for multiple system atrophy therapy via α-synuclein/FABP7 propagation
Authors: Cheng An , Kawahata Ichiro , Wang Yifei , Jia Wenbin , Wang Haoyang , Sekimori Tomoki , Chen Yi , Suzuki Hiroyoshi , Takeda Atsushi , Stefanova Nadia , Finkelstein David I , Ma Wenbo , Chen Min , Sasaki Takuya , Fukunaga Kohji 
Published: April 2023

Abstract
Multiple system atrophy (MSA) is a neurodegenerative disease characterized by the accumulation of misfolded α-synuclein (αSyn) and myelin disruption. However, the mechanism underlying αSyn accumulation in MSA brains remains unclear. Here, we aimed to identify epsin-2 as a potential regulator of αSyn propagation in MSA brains.
In the MSA mouse model, PLP-hαSyn mice, and FABP7/αSyn hetero-aggregate-injected mice, we initially discovered that fatty acid-binding protein 7 (FABP7) is related to MSA development and forms hetero-aggregates with αSyn, which exhibit stronger toxicity than αSyn aggregates. Moreover, the injected FABP7/αSyn hetero-aggregates in mice selectively accumulated only in oligodendrocytes and Purkinje neurons, causing cerebellar dysfunction.
Furthermore, bioinformatic analyses of whole blood from MSA patients and FABP7 knockdown mice revealed that epsin-2, a protein expressed in both oligodendrocytes and Purkinje cells, could potentially regulate FABP7/αSyn hetero-aggregate propagation via clathrin-dependent endocytosis.
Lastly, adeno-associated virus type 5-dependent epsin-2 knockdown mice exhibited decreased levels of αSyn aggregate accumulation in Purkinje neurons and oligodendrocytes, as well as improved myelin levels and Purkinje neuron function in the cerebellum and motor performance. These findings suggest that epsin-2 plays a significant role in αSyn accumulation in MSA, and we propose epsin-2 as a novel therapeutic target for MSA.
Epidemiology of Pulmonary and Extrapulmonary Nontuberculous Mycobacteria Infections at 4 US Emerging Infections Program Sites: A 6-Month Pilot
Authors: Grigg Cheri , Jackson Kelly A , Barter Devra , Czaja Christopher A , Johnston Helen , Lynfield Ruth , Vagnone Paula Snippes , Tourdot Laura , Spina Nancy , Dumyati Ghinwa , Cassidy P Maureen , Pierce Rebecca , Henkle Emily , Prevots D Rebecca , Salfinger Max , Winthrop Kevin L , Toney Nadege Charles , Magill Shelley S 
Published: April 2023

Abstract

Background
Nontuberculous mycobacteria (NTM) cause pulmonary (PNTM) and extrapulmonary (ENTM) disease. Infections are difficult to diagnose and treat, and exposures occur in healthcare and community settings. In the United States, NTM epidemiology has been described largely through analyses of microbiology data from health departments, electronic health records, and administrative data. We describe findings from a multisite pilot of active, laboratory- and population-based NTM surveillance.

Methods
The Centers for Disease Control and Prevention’s Emerging Infections Program conducted NTM surveillance at 4 sites (Colorado, 5 counties; Minnesota, 2 counties; New York, 2 counties; and Oregon, 3 counties [PNTM] and statewide [ENTM]) from 1 October 2019 through 31 March 2020. PNTM cases were defined using published microbiologic criteria. ENTM cases required NTM isolation from a nonpulmonary specimen, excluding stool and rectal swabs. Patient data were collected via medical record review.

Results
Overall, 299 NTM cases were reported (PNTM: 231, 77%); Mycobacterium avium complex was the most common species group. Annualized prevalence was 7.5/100 000 population (PNTM: 6.1/100 000; ENTM: 1.4/100 000). Most patients had signs or symptoms in the 14 days before positive specimen collection (ENTM: 62, 91.2%; PNTM: 201, 87.0%). Of PNTM cases, 145 (62.8%) were female and 168 (72.7%) had underlying chronic lung disease. Among ENTM cases, 29 (42.6%) were female, 21 (30.9%) did not have documented underlying conditions, and 26 (38.2%) had infection at the site of a medical device or procedure.

Conclusions
Active, population-based NTM surveillance will provide data for monitoring the burden of disease and characterize affected populations to inform interventions.
Menger or Marx? The political ontology of cryptocurrency
Authors: Rector Tully , Allen Jason Grant 
Published: April 2023

Abstract
One of the perennial fault-lines in monetary theory is that between commodity and credit theories of money. The emergence of alternative payment systems based on blockchain and distributed ledger technologies, of which Bitcoin is the most prominent example, has raised a host of important questions in relation to this debate. This article considers two. The first is ontological: Are Bitcoin and similar ‘cryptocurrencies’ best conceived of as money? The second is political: Do these money candidates represent an emancipatory development over state-backed fiat currency? The ontological question, we will argue, invites the political one. If it is the case, as Chartalists maintain, that (i) for some X to be money it must have certain properties which can only be imparted by political authority (broadly understood) and if (ii) political authority ought to be subject to public control, then attempts by private actors to usurp a social ‘money function’ cannot count as legitimate political developments. We will argue in support of this position. This discussion is limited to Bitcoin, though its implications generalize for relevantly similar cryptocurrencies. Our method involves considering, first, claims made by Bitcoin’s defenders about its status as money, and what accounts for that status. While these claims are often thought to extend Mengerite or generally Austrian lines of economic argument, they resonate more with Marx’s theory of monetary value. Moreover, a close assessment of that theory’s defects yields specific normative conclusions that potentially undermine the notion that Bitcoin constitutes a valid means of resisting state monetary authority.
Exchange liquidity and redemption liquidity
Authors: Culham James 
Published: April 2023

Abstract
Disagreements over the nature of money and consequent confusions regarding liquidity contribute to difficulties integrating monetary theory into the theory of value. For example, an abundance of market liquidity is assumed in asset pricing, whereas a scarcity of monetary liquidity is deemed necessary for consumer price-level determinacy. This paper builds on the insights gained from the evolution of finance to introduce a distinction between exchange liquidity and redemption liquidity as a means of resolving this conceptual dissonance. Both exchange and redemption liquidity can be conceptualised as types of financial option differing in the exercise mechanism offered to the option holder by the option-writer.
Association of Antibiotic Use with Durability of Biologic Agents in Inflammatory Bowel Disease: a Report from the epi-IIRN
Authors: Gorelik Yuri , Ghersin Itai , Shlon Deema , Friss Chagit , Lujan Rona , Loewenberg Weisband Yiska , Greenfeld Shira , Kariv Revital , Ledderman Natan , Matz Eran , Dotan Iris , Bar-Yoseph Haggai , Chowers Yehuda , Turner Dan 
Published: April 2023

AbstractBackgroundDifferent antibiotic classes were reported to have variable effects on immunogenicity towards anti-tumour necrosis factor [TNF] agents. However, the impact of antibiotic administration on biologic treatment durability was not investigated. We aimed to assess the association between antibiotic treatment and persistence of different classes of biologic therapy in inflammatory bowel disease [IBD] patients.MethodsData from the epi-IIRN, a nationwide registry of all Israeli IBD patients were analysed. All patients who filled a prescription of either infliximab, adalimumab, vedolizumab, or ustekinumab, were included. Treatment cessation was defined as drug discontinuation of at least 6 months. Macrolides, cephalosporins, fluoroquinolones, and penicillins with beta-lactamase inhibitors were selected as primary exposure variables. Survival analysis was performed using marginal structural models for each drug separately.ResultsIn all 13 513 IBD patients, with a total of 39 600 patient-years, were included. Significant differences of overall treatment persistence were demonstrated, with highest persistence rates for ustekinumab and the lowest for infliximab treatment. Macrolides were found to be significantly associated with reduced risk of infliximab cessation (adjusted hazard ratio [aHR] 0.72, 95% CI 0.62-0.89]. Fluoroquinolones and cephalosporins were associated with an elevated risk of adalimumab treatment cessation [aHR 1.33, 95% CI 1.22-1.46; and aHR 1.20, 95% CI 1.08-1.34, respectively]. No significant effects of the studied antibiotics were observed in ustekinumab and vedolizumab users.ConclusionsSpecific antibiotic classes are associated with duration of anti-TNF treatment, but not with durability of vedolizumab or ustekinumab treatments. Further research is required to study the effect of specific antibiotics on response to biologics.
Insect wood borers on commercial North American tree species growing in China: review of Chinese peer-review and grey literature
Authors: Dong Yiyi , Gao Jie , Hulcr Jiri 
Published: April 2023

AbstractInvasive insect wood borers are a threat to global forests and tree-related industries as they can damage trees and spread plant pathogens. Reports of damages by wood borers on plants that were planted overseas may facilitate the identification of potential invaders and speed up risk assessment. However, much of this information remains unavailable to the international plant protection community due to language barriers, lack of digitization, or limited circulation of regional literature. Here, we investigated reports of wood borers on 7 important North American commercial tree species planted in China (Carya illinoinensis, Liquidambar styraciflua, Pinus elliottii, Pinus taeda, Quercus texana, Quercus rubra, and Quercus virginiana) in peer-reviewed as well as “grey” (nonpeer-reviewed) Chinese literature. A total of 60 unique wood borer records were found, yielding reports of 4 orders, 39 genera, and 44 species of insect wood borers. Among Coleoptera, longhorned beetles (Cerambycidae) were the most commonly reported colonizers of North American trees in China. Chinese peer-reviewed reports of pests on alien plants are a valuable tool to survey for potential wood-boring invaders of North America, and wherever North American trees are planted and have the potential to encounter Asian invasive insects. Digitization and dissemination of non-English literature are essential for contemporary risk assessment. On the other hand, the nonpeer reviewed “grey” literature, primarily agency reports and student theses, provided only 5% of the records; many incidental observations were unreliable.
Cardiac toxicity of chemotherapy for breast cancer: do angiotensin-converting enzyme inhibitors and beta blockers protect?
Authors: Bisceglia Irma , Mistrulli Raffaella , Cartoni Domenico , Matera Sabrina , Petrolati Sandro , Canale Maria Laura 
Published: April 2023

Abstract
Cardiotoxicity is a relatively frequent and potentially serious side effect of anticancer treatments, particularly anthracyclines and trastuzumab, widely used in the treatment of breast cancer. The increase in cancer survivors has generated a growing interest in the prevention of cardiotoxicity. Although early studies suggested an overall benefit on cardiac function with the use of ACE inhibitors (ACEIs) and beta blockers (BBs), more recent randomized trials have demonstrated little or no effect of pharmacological interventions. Even the various meta-analyses conducted in this area have provided weak results in favour of cardioprotective therapies for which the benefit would not always justify the risk of developing side effects. Given the incompleteness of the evidence, there is no clear consensus on which patients should initiate cardioprotective therapy. As recommended in the new guidelines of the European Society of Cardiology, risk stratification before treatment is crucial to identify high-risk patients who would benefit most from the use of cardioprotective therapy. Randomized trials are currently underway to evaluate other therapeutic strategies such as sacubitril/valsartan, and the possibility of using gliflozins in the future cannot be excluded. However, rigorous control and treatment of risk factors remain the primary focus in the management of these patients.