bluuebunny/crossref_metadata_2025_split huggingface dataset:
Real-time, random-access organ screening for carbapenem-resistant Enterobacterales (CRE) reduces CRE- associated, donor-derived infection mortality in recipients
Authors: Zhou Wen-Yong , Shen Lei , Shi Jian-Xin , Gao Xing-Hui , Yang Jun , Fu Shi-Jie , Pan Xu-Feng , Zhu Min-Fang , Zhang Shen , Zhang Chong , Li Feng , Zhang Hai , Yao Feng , Tenover Fred C. , Tang Yi-Wei , Fang Wen-Tao 
Published: May 2023

Abstract
Purpose: Donor-derived infection (DDI) has become an important factor affecting the prognosis of lung transplantation patients. The risks versus benefits of using donor organs infected with multidrug-resistant organisms (MDRO), especially carbapenem-resistant Enterobacterales (CRE), are frequently debated. Traditional microbial culture and antimicrobial susceptibility testing at present fail to meet the needs of quick CRE determination for donor lung before acquisition. In this study, we explored a novel accurate screening method by using Xpert® Carba-R assay for CRE in donor lungs in a real-time manner to reduce CRE-associated DDI mortality.
Methods: This study was registered on chictr.org.cn (ChiCTR2100053687) on November, 2021. In the Xpert Carba-R screening group, donor lungs were screened for CRE infection by Xpert Carba-R test on bronchoalveolar lavage fluid (BALF) before acquisition. If the result was negative, donor lung acquisition and subsequent lung transplantation were performed. In the control group, the recipients underwent lung transplants without Xpert Carba-R screening. The incidence and mortality of CRE-associated DDI were collected and contrasted between the two groups.
Results: Multivariate analysis showed that CRE-related death due to DDI within 60 days was significantly lower in the Xpert Carba-R screening group than that in the control group (OR = 0.049, 95% CI = 0.003-0.736, p = 0.029).
Conclusion: Real-time CRE screening of donor lungs before transplantation at the point of care by the Xpert Carba-R helps clinicians formulate lung transplantation strategies quickly and reduces the risk of subsequent CRE infection improving the prognosis of lung transplantation.
Survival Impact of Immediate Complete Lymph Node Dissection for Chinese Acral and Cutaneous Melanoma with Micrometastasis in Sentinel Nodes: A Retrospective Study
Authors: Zhong Jingqin , Zou Zijian , Hu Tu , Sun Wei , Wang Chunmeng , Yan Wangjun , Luo Zhiguo , Liu Xin , Xu Yu , Chen Yong 
Published: May 2023

Abstract
Background Sentinel node biopsy (SNB) has become a critical part of standard surgical treatment for melanoma with no metastatic evidence. According to MSLT-II and DeCOG-SLT trials, for patients with positive sentinel nodes, immediate complete lymph node dissection (CLND) didn’t bring further benefit for patients’ survival. Argument remains among Chinese population with domination of acral subtypes whether CLND can be omitted. This study aims to investigate the impact of immediate CLND for SN positivity on relapse-free survival (RFS) in Chinese melanoma patients.Material and Methods Patients with acral or cutaneous melanoma of clinical stage I-II receiving SNB procedure and then detected with nodal micrometastasis were retrospectively identified at Fudan University Cancer Center (FUSCC) from January 2017 to December 2021. Clinicopathologic features and prognostic factors for RFS were analyzed.Results Among 381 patients who received SNB in the last five years, 130 (34%) cases with positive SN micrometastasis detected were identified in our study. 99 patients underwent immediate CLND while the other patients received observation alone. Among patients received CLND, the NSN positive rate was 22.2%. There were slightly less N1 stage in the CLND group compared to the non-CLND group, although the difference didn’t reach statistical significance (P = 0.075). There was no significant difference in RFS between the two groups (P = 0.184).Conclusions Immediate CLND didn’t bring further RFS benefit after an observation for Chinese melanoma with SN micrometastasis in real clinical practice, even for patients with acral subtype or more tumor burden such as thick Breslow invasion and ulceration.
Bibliometric Analysis of Trends in Stem Cell Therapy for Hip Osteoarthritis from 1990 to 2023
Authors: Qiu Binsong , Bi Qing 
Published: May 2023

Abstract
Background The rapid growth in the prevalence of hip osteoarthritis, in conjunction with the worldwide increase in the average age of the population, has attracted the interest of many researchers. Our objective was to identify research trends in stem cell therapy for hip osteoarthritis and to evaluate the most-reviewed high-quality scientific articles related to stem cells.Methods All stem cell therapy for hip osteoarthritis publications were retrieved from the Web of Science Core Collection database. We analyzed all publications by years of publication in this field, country, institution, total citations, and journal. Publication performance was assessed by numerous bibliometric criteria, like VOSviewer, to discover topic trends in the research landscape. At the same time, the 100 stem cell articles with the most citations were extracted and analyzed.Results A total of 1099 publications associated with stem cell therapy for hip osteoarthritis were included between 1990 and 2023. Globally, the country with the most published articles on stem cell treatment for hip osteoarthritis is the United States, with 713. Helsinki University had the most publications of any institution (n = 48). The journal "Osteoarthritis and Cartilage" has published 54 publications with a total of 3090 citations.Conclusion This study represents the latest bibliometric analysis of stem cell therapy for hip osteoarthritis. The main objective is to highlight present and prospective research hotspots for clinicians and researchers in the field.
Self-management support (SMS) in primary care practice: a qualitative focus group study of care professionals’ experiences
Authors: Timmermans Lotte , Boeykens Dagje , Sirimsi Muhammed Mustafa , De Vriendt Patricia , Decat Peter , Hecke Ann Van , Vermandere Mieke , Schoenmakers Birgitte , de Velde Dominique Van , Foulon Veerle 
Published: May 2023

Abstract
Background: To support self-management of chronically ill persons, innovative approaches of care practice are being developed. Unfortunately, many self-management supporting interventions struggle to achieve reliable and consistent improvements at various levels (patient, provider and healthcare system level). One possible strategy to facilitate translating theory into practice, is to consider the healthcare professionals’ perspective prior to the development of new interventions. An exploration of their knowledge and opinion about barriers and facilitators is necessary before employing any self-management support (SMS) intervention. Therefore, our study aims to explore care professionals’ perspectives about SMS within the Flemish primary care setting.
Methods: This study used a qualitative study design to examine SMS in primary care setting. Five focus groups were conducted, grouped into three waves. Participants were healthcare professionals in Flanders representing different disciplines and settings. A maximum variation purposive sampling was used to recruit participants. For the data analysis, the framework of thematic networks by Attride-Stirling was applied.
Results: A total of 34 healthcare professionals participated. Three global themes related to SMS were derived from the thematic analysis: (1) Characteristics, (2) Support strategies, (3) Barriers and facilitators. SMS was characterised as a collaboration-based and person-centred approach. A variety of supporting strategies were mentioned by the focus group participants. Most strategies consisted of informing and educating patients. Complementary to individual strategies, collaborative strategies were deemed necessary to support self-management. Regarding barriers and facilitators, different patient-related factors were identified. Additionally, competencies of healthcare providers and external factors seem to hinder the implementation of SMS in practice.
Conclusions: This focus group study highlights the importance of a collaborative, person-centred approach to SMS in the context of chronic diseases. Our findings point to the need for interventions that raise awareness and address barriers associated with SMS. Since generic SMS does not exist, the road to success is a growth process in which support must be adapted to the individual patient.
Ibrutinib plus fludarabine, cyclophosphamide and rituximab (iFCR) as initial treatment in chronic lymphocytic leukemia/ small lymphocytic leukemia with or without TP53 aberrations: A prospective real-world study in Chinese cohort
Authors: ZHU Hua-Yuan , Miao Yi , Sha Yeqin , Xia Yi , Qin Shu-Chao , Jiang Rui , Dai Luomengjia , Shen Hui , Qiu Tonglu , Wu Wei , Qiu Jingyan , Yang Yilian , Ding Chong-Yang , Wu Yujie , Fan Lei , Xu Wei , Li Jianyong 
Published: May 2023

Abstract
Time-limited treatment strategies in first line treatment of chronic lymphocytic leukemia/small lymphocytic leukemia (CLL/SLL) were comprehensively explored. Thirty-four previously untreated, young fit CLL/SLL patients who initiated iFCR regimen between January 2019 and Match 2021 were included in our cohort. iFCR were administered every 28-day cycle, with a maximum of six cycles. Patients who achieved complete remission or complete remission with incomplete recovery (CR/CRi) and bone marrow (BM) undetectable minimal residual disease (uMRD) 2 years after iFCR initiation were feasible to discontinue ibrutinib maintenance. 61.8% (21/34) patients had IGHV unmutated status and 17.6% (6/34) patients had TP53 mutation and/or del(17p). CR/CRi rate was 35.3% (12/34) and BM uMRD rate was 41.2% (14/34) after three cycles of iFCR, and increased to 55.9% (19/34) after eight cycles. The best response of CR/CRi rate and BM uMRD rate were both 73.5% (25/34). With the median follow-up of 33 months, the 3-year PFS and OS rate was 80.0% and 95.5%, respectively. CR/CRi rate and BM uMRD rate was comparable between patients with IGHV mutated and unmutated status without TP53 aberrations, while all patients with TP53 aberrations failed to achieve sustainable CR/CRi or BM uMRD. The most common hematological adverse events were neutropenia (25/34, 73.5%) and thrombocytopenia (24/34, 70.6%) and the most common non-hematological adverse events were nausea (21/34, 61.8%), fatigue (16/34, 47.1%) and vomiting (15/34, 44.1%). The iFCR regimen could achieve high response rate and proportion of uMRD as initial treatment for young fit CLL/SLL patient absence of TP53 aberration with acceptable overall tolerability.
Open set domain adaptive method based on energy separation strategy
Authors: Chai Hao , Wang Shengsheng , Long Sifan , Hao ZhiWei , Li Yiyang 
Published: May 2023

Abstract
Open Set Domain Adaptation (OSDA) aims to reduce the variation across domains while distinguishing between known samples and unknown samples. However, existing OSDA methods are based on deep neural network classifiers to separate unknown samples, which leads the network to produce overconfident predictions and fails to establish the boundary between the known and the unknown. We propose an Energy-based Open Set Domain Adaptation method (EOS). Specifically, EOS is a new two-stage approach of separation followed by alignment. We use an energy-based anomaly detection strategy as a separation method for unknown samples, transforming the traditional K-way classification task into a K+1-dimensional classifier that uses an additional dimension to model the uncertainty of Out-of-distribution (OOD) samples. Then, we use a coarse-to-fine separation method to continuously adjust the separation results and add the exact separation results as weights in the alignment process, weighing their importance to the feature distribution alignment. In the alignment phase we also optimize our separation network module at the same time, so that the module can be better adapted with invariant features. We have done experiments on the standard ground Office-31, Office-Home, and VisDA-2017 benchmarks, and the results show that our approach outperforms our competitors in most cases.
Agaricus Subrufescens Ameliorates Ovarian Dysfunction and Regulates Altered Biochemical Parameters in Rats with Letrozole Induced Polycystic Ovarian Syndrome
Authors: Bukke Sarad Pawar Naik , PATHANGE Bharghava Bhushan Rao , KARUMANCHI Srikanth Kumar , MARRI Jalaiah , BOYINA Revathi , MANCHIKALAPATI Kavya , Bhargavi MANCHIKALAPATI , ODOMA Saidi , BELLO Hussaini 
Published: May 2023

Abstract
Objective To examine the impact of an ethonolic extract of Agaricus subrufescens on rat models of Polycystic Ovarian Syndrome (PCOS) produced by letrozole.Methods Thirty female Wistar rats were split into five six-rat groups. Negative controls received 1 mL of 0.5% carboxy methylcellulose (CMC). Other groups received letrozole (1 mg/kg) for 21 days to induce PCOS. Positive control animals were slaughtered on day 22. The test and standard groups received treatment from the 22nd to the 36th day. The test group received Agaricus subrufescens ethanoic extract (200 mg/kg, 400 mg/kg, p.o.) and the standard group clomiphene citrate (1 mg/kg). Estimated blood glucose, total cholesterol, triglycerides, and hormonal changes like increased testosterone, oestrogen, and decreased progesterone with menstrual irregularity confirmed by vaginal smears and histopathological ovary changes in polycystic ovarian disease control.Results Agaricus subrufescens reduced blood glucose, testosterone, anovulation, and menstrual irregularity. All therapies markedly corrected SGOT and SGPT levels. Letrozole-induced PCOS rats had elevated urea and creatinine. This study suggests that Agaricus subrufescens therapy protects renal function by lowering serum urea and creatinine. In letrozole-induced PCOS rats, suppressing hepatic synthesis, increasing ovarian follicle immaturity, and boosting androgen discharges increase liver and ovary weight. Endocrine organ weight decreased in all treatment groups. PCOS control histopathology indicated more cysts and theca lutein cells. PCOS control rats had more cysts than treatment groups.Conclusion Oral letrozole produced polycystic ovarian disease in this research. It showed elevated blood glucose, total cholesterol, triglycerides, and hormonal changes like increased testosterone and oestrogen and decreased progesterone with menstrual irregularity confirmed by vaginal smears and histopathological changes in the ovary of polycystic ovarian disease control. Blood glucose, total cholesterol, and testosterone levels dropped in Agaricus subrufescens treatment groups.
HSFO: Hunter Sail Fish Optimizer enabled deep learning for single document abstractive summarization based on semantic role labelling for Telugu text
Authors: Aluri Lakshmi , D Latha 
Published: May 2023

Abstract
Accessing information from online has become difficult problem due to the internet's explosive rise in textual resources. User’s frequently sought for topic summaries from multiple sources to satisfy their informational demands. Single document abstractive summarization is significant role in Natural Language Processing (NLP) aiming to generate concise summary of source text from single document. Method of producing natural language summaries from text, keeping key points of the input document as such is a challenging task. In this research, hybrid optimization algorithm, namely proposed Hunter Sail Fish Optimizer (HSFO) is used leading to abstractive summarization. Here, acquired document is allowed for Semantic Role Labeling (SRL), at which Stanza tool is used for extraction of Predicate Argument Structures (PAS). Next to SRL, optimized features are generated by computation of semantic similarity using Wave-Hedges metrics. Moreover, semantic feature clustering of PAS is performed using Bayesian Fuzzy Clustering (BFC). Then, feature score is generated by utilization of HSFO for parameter selection, leading to abstractive summarization by Long Short-Term Memory-Convolutional Neural Network (LSTM-CNN). Here, HSFO is devised by combining Hunter-Prey Optimizer (HPO) and Sail Fish Optimizer (SFO). The dataset used in this work is Telugu dataset, from which text document in the sentence form is acquired. Finally, performance of HSFO_LSTM-CNN is analyzed by using four performance measures, precision, recall, F-measure, and Rouge, which shows superior values of precision as 0.887, recall as 0.925, F-measure as 0.906, and rouge as 0.815.
Telerehabilitation in patients with recent hospitalisation due to Acute Decompensated Heart Failure: protocol for the Tele-ADHF randomised controlled trial
Authors: Leunen Mayke M.C.J. van , De Lathauwer Ignace , Verstappen Cindy C.A.G. , Visser-Stevelink Dianne M.G. , Brouwers Rutger W.M. , Herkert Cyrille , Tio René A. , Spee Ruud F. , Lu Yuan , Kemps Hareld M.C. 
Published: May 2023

Abstract
Background Cardiac rehabilitation in patients with chronic heart failure (CHF) has favourable effects on exercise capacity, the risk at hospital (re-)admission and quality of life. Although cardiac rehabilitation is generally recommended it is still under-utilised in daily clinical practice, particularly in frail elderly patients after hospital admission, mainly due to low referral and patient-related barriers. Cardiac telerehabilitation (CTR) has the potential to partially solve these barriers. The purpose of this study is to evaluate the effects of CTR as compared to standard remote care after hospital admission on physical functional capacity in CHF patients.Methods In this randomised controlled trial, 64 CHF patients will be recruited during hospitalisation for acute decompensated heart failure, and randomised to CTR combined with remote patient management (RPM) or RPM alone (1:1). All participants will start with RPM after hospital discharge for early detection of deterioration, and will be up titrated to optimal medical therapy before being randomised. CTR will start after randomisation and consists of an 18-week multidisciplinary programme with exercise training by physical and occupational therapists, supported by a (remote) technology-assisted dietary intervention and mental health guiding by a physiologist. The training programme consists of three centre-based and two home-based video exercise training sessions followed by weekly video coaching. The mental health and dietary programme are executed using individual and group video sessions. A wrist-worn device enables remote coaching by the physical therapist. The web application is used for promoting self-management by the following modules: 1) goal setting, 2) progress tracking, 3) education, and 4) video and chat communication. The primary outcome measure is physical functional capacity evaluated by the Short Physical Performance Battery (SPPB) score. Secondary outcome measures include frailty scoring, recovery after submaximal exercise, subjective health status, compliance and acceptance to the rehabilitation programme, and readmission rate.Discussion The Tele-ADHF trial is the first prospective randomised controlled trial designed for evaluating the effects of a comprehensive combined RPM and CTR programme in recently hospitalised CHF patients. We hypothesize that this intervention has superior effects on physical functional capacity than RPM alone.Trial registration: Netherlands Trial Registry (NTR) NL9619, registered 21 July 2021.
Potential Erosion Mapping Using Machine Learning Methods (Case Study: Rud-e-Faryab Basin, Bushehr Province, Iran)
Authors: Damaneh Javad Momeni , Safdari Ali Akbar , Azarnejad Nazanin , Ghorbani Majid , Panahi Fatemeh , Loppi Stefano 
Published: May 2023

Abstract
Purpose.
The requirement of soil erosion management is to provide appropriate solutions which can be obtained by recognizing the state of soil erosion. The purpose of the study is to model the potential erosion using 10 environmental variables and 10 models in BIOMOD-2 package in R software and to evaluate the stability of the model in order to be aware of the sensitivity of erosion in Rud-e-Faryab basin in Bushehr province.
Methods. In addition, the location of five dominant erosions of the basin was recorded using GPS. These events were classified into two groups of training and validation with a ratio of 70 to 30. In order to evaluate the stability, the BIOMOD-2 package model was repeated 10 times. The efficiency of the model was evaluated using ROC, KAPPA and TSS.
Results. According to stability results, the best models are determined as GLM model with the accuracy of above 70% in low-rated waterway erosion, RF model with the accuracy of above 80% in medium-rated waterway erosion, ANN and SRE models with 100% accuracy in medium-rated rill erosion, MARS model with accuracy above 60% in high-rated rill erosion and GLM model with accuracy above 80% in medium-rated stream bank erosion according to all three validation parameters.
Conclusion. These results indicate high agreement with studies which have used the vector machine models as an effective tool in preparing the potential erosion map of watersheds. In general, it can be said that vector machine methods are a helpful new approach for land use planning and erosion risk management.
Modelling the degradation of acidic and alkaline printing paper
Authors: Tétreault Jean , Vedoy Diogenes , Bégin Paul , Sabrina Paris Lacombe , Dupont Anne-Laurence 
Published: May 2023

Abstract
There has always been an interest in the professional communities of libraries, archives and conservation science to find ways of estimating the rate of degradation of paper under archival conservation conditions. Previously we reported a number of considerations for developing a kinetic degradation model based on Whatman no.1 paper. In the present research, this model was extended to 10 different papers and validated. Various physical and chemical properties of acidic, neutral, and alkaline papers were measured, such as the degree of polymerization (DP), tensile strength, equilibrium moisture content (EMC), and pH, as well as alkaline reserve when applicable. The activation energy (Ea) based on DP of cellulose and zero-span tensile strength were determined. Ea and pH had the most significant influence on the simulated decay of paper. Papers with a high Ea (> 120 kJ mol-1), alkaline such as those containing at least 2% CaCO3, and acidic –but good printing quality papers made of bleached chemical pulp– were found the most durable in ambient conditions. Papers with a lower Ea (< 110 kJ mol-1) such as lignocellulosic papers containing significant amount of mechanical pulp were much less stable over time. Whatman filter papers, used as models of pure cellulosic papers, were found to have low Ea despite the good quality cotton fibers. A generic isoperm equation based on Ea was developed to predict the changes in the state of papers under various climatic conditions, and was applicable independently of the pH of the paper. The model developed allows a better quantification of the deterioration rate of printing papers such as those that are currently, and will be in the future, found in our archival collections.