bluuebunny/crossref_metadata_2025_split huggingface dataset:
Signal timing at an isolated intersection under mixed traffic environment with self‐organizing connected and automated vehicles
Authors: Ma Chengyuan , Yu Chunhui , Zhang Cheng , Yang Xiaoguang 
Published: December 2022

AbstractThis study provides a signal timing model for isolated intersections under the mixed traffic environment consisting of connected and human‐driven vehicles (CHVs) and connected and automated vehicles (CAVs). Different from existing studies, CAVs are not controlled by traffic controllers and conduct trajectory planning themselves, which are called self‐organizing CAVs (SOCAVs). The specific trajectory planning strategies of SOCAVs are not accessible to traffic controllers either. The signal optimization problem is formulated as a mixed integer linear programming (MILP) model for total vehicle delay minimization. The states of SOCAVs and CHVs passing the stop bar are predicted without prior information of the trajectory planning strategies of SOCAVs. SOCAVs can lead approaching platoons to pass the intersection effectively, and such “leading effects” of SOCAVs are utilized. Phase sequence and duration are optimized with the “structure‐free” phasing scheme. A parallel particle swarm optimization algorithm with a grouping strategy is designed to solve the optimization model at a reduced scale for computational efficiency. Numerical studies validate that (1) the proposed algorithm significantly outperforms the benchmark method, which directly solves the proposed MILP model using the solver Gurobi 9.0, under medium and high traffic demand; and (2) the proposed model significantly outperforms fixed‐time and vehicle‐actuated signal control in terms of vehicle delay and throughput. Sensitivity analysis shows that the SOCAV penetration rate of 30% is sufficient to guarantee satisfactory performance of the proposed signal timing model.
Displacement measurement of large structures using nonoverlapping field of view multi‐camera systems under six degrees of freedom ego‐motion
Authors: Yu Qifeng , Yin Yihe , Zhang Yueqiang , Chen Wenjun , Hu Biao , Liu Xiaolin 
Published: December 2022

AbstractIn this work, a non‐overlapping field of view (FOV) multi‐camera system (MCS) has been proposed to realize the motion self‐compensation, which can be flexibly arranged according to the field situation. The challenges of ensuring a complete fixed measurement platform owing to the self‐weight, unexpected collisions, and adjacent engineering constructions have been addressed in this study. MCS can be fixed on an unstable platform and employ two or more correcting cameras, without an overlapping FOV, to measure and compensate the six degrees of freedom (6‐DOF) ego‐motion of the platform, with high accuracy. The numerical simulation results show that, under the same configuration conditions, the 6‐DOF motion estimation accuracy of the proposed method is better than that of the Perspective‐n‐Points methods, especially for the estimation accuracy of the out‐of‐plane motion and the roll motion of the camera. The field demonstration has been performed on a suspension bridge, and the results demonstrate that the deflection measurements provided by the proposed MCS are consistent with those provided by the Robotic Total Station. The proposed MCS, which is not restrained by a strictly stable platform, proves to be an effective method to compensate for the errors induced by the platform ego‐motion, and it can meet the requirements of the displacement measurement of large structures needing high precision.
High ambient temperature impacts on flowering time in Brassica napus through both H2A.Z‐dependent and independent mechanisms
Authors: Abelenda José A. , Trabanco Noemí , del Olmo Iván , Pozas Jenifer , Martín‐Trillo María del Mar , Gómez‐Garrido Jessica , Esteve‐Codina Anna , Pernas Mónica , Jarillo José A. , Piñeiro Manuel 
Published: December 2022

AbstractKnowledge concerning the integration of genetic pathways mediating the responses to environmental cues controlling flowering initiation in crops is scarce. Here, we reveal the diversity in oilseed rape (OSR) flowering response to high ambient temperature. Using a set of different spring OSR varieties, we found a consistent flowering delay at elevated temperatures. Remarkably, one of the varieties assayed exhibited the opposite behaviour. Several FT‐like paralogs are plausible candidates to be part of the florigen in OSR. We revealed that BnaFTA2 plays a major role in temperature‐dependent flowering initiation. Analysis of the H2A.Z histone variant occupancy at this locus in different Brassica napus varieties produced contrasting results, suggesting the involvement of additional molecular mechanisms in BnaFTA2 repression at high ambient temperature. Moreover, BnARP6 RNAi plants showed little accumulation of H2A.Z at high temperature while maintaining temperature sensitivity and delayed flowering. Furthermore, we found that H3K4me3 present in BnaFTA2 under inductive flowering conditions is reduced at high temperature, suggesting a role for this hallmark of transcriptionally active chromatin in the OSR flowering response to warming. Our work emphasises the plasticity of flowering responses in B. napus and offers venues to optimise this process in crop species grown under suboptimal environmental conditions.
Effects of motor pacing on frontal‐hemodynamic responses during continuous upper‐limb and whole‐body movements
Authors: Guérin Ségolène M. R. , Vincent Marion A. , Delevoye‐Turrell Yvonne N. 
Published: December 2022

AbstractAdvances in timing research advocate for the existence of two timing mechanisms (automatic vs. controlled) that are related to the level of cognitive control intervening for motor behavior regulation. In the present study, we used the functional near‐infrared spectroscopy (fNIRS) cutting‐edge technique to examine the hypothesis that prefrontal inhibitory control is needed to perform slow motor activities. Participants were asked to perform a sensorimotor‐synchronization task at various paces (i.e., slow, close‐to‐spontaneous, fast). We contrasted upper‐limb circle drawing to a more naturalistic behavior that required whole‐body movements (i.e., steady‐state walking). Results indicated that whole‐body movements led to greater brain oxygenation over the motor regions when compared with upper‐limb activities. The effect of motor pace was found in the walking task only, with more bilateral orbitofrontal and left dorsolateral activation at slow versus fast pace. Exploratory analyses revealed a positive correlation between the activation of the orbitofrontal and motor areas for the close‐to‐spontaneous pace in both tasks. Overall, results support the key role of prefrontal cognitive control in the production of slow whole‐body movements. In addition, our findings confirm that upper‐limb (laboratory‐based) tasks might not be representative of those engaged during everyday‐life motor behaviors. The fNIRS technique may be a valuable tool to decipher the neurocognitive mechanisms underlying naturalistic, adaptive motor behaviors.
MUC5B rs35705950 minor allele associates with older age and better survival in idiopathic pulmonary fibrosis
Authors: van der Vis Joanne J. , Prasse Antje , Renzoni Elisabetta A. , Stock Carmel J. W. , Caliskan Canay , Maher Toby M. , Bonella Francesco , Borie Raphael , Crestani Bruno , Petrek Martin , Wuyts Wim A. , Wind Anne E. , Molyneaux Philip L. , Grutters Jan C. , van Moorsel Coline H. M. 
Published: December 2022

AbstractBackground and ObjectiveThe minor T‐allele of the MUC5B promoter polymorphism rs35705950 is strongly associated with idiopathic pulmonary fibrosis (IPF). However, conflicting results have been reported on the relationship between the MUC5B minor allele and survival and it is unknown whether a specific subgroup of IPF patients might benefit from MUC5B minor allele carriage. We investigated the association between MUC5B rs35705950, survival and patient characteristics in a real‐world population of European IPF patients.MethodsIn this retrospective study, 1751 patients with IPF from 8 European centres were included. MUC5B rs35705950 genotype, demographics, clinical characteristics at diagnosis and survival data were analysed.ResultsIn a multi‐variate Cox proportional hazard model the MUC5B minor allele was a significant independent predictor of survival when adjusted for age, sex, high resolution computed tomography pattern, smoking behaviour and pulmonary function tests in IPF. MUC5B minor allele carriers were significantly older at diagnosis (p = 0.001). The percentage of MUC5B minor allele carriers increased significantly with age from 44% in patients aged <56 year, to 63% in patients aged >75. In IPF patients aged <56, the MUC5B minor allele was not associated with survival. In IPF patients aged ≥56, survival was significantly better for MUC5B minor allele carriers (45 months [CI: 42–49]) compared to non‐carriers (29 months [CI: 26–33]; p = 4 × 10−12).ConclusionMUC5B minor allele carriage associates with a better median transplant‐free survival of 16 months in the European IPF population aged over 56 years. MUC5B genotype status might aid disease prognostication in clinical management of IPF patients.
Smartphone use, off‐farm employment, and women's decision‐making power: Evidence from rural China
Authors: Zheng Hongyun , Zhou Yuwen , Rahut Dil Bahadur 
Published: December 2022

AbstractEmpowering women is an important goal of the United Nations' Sustainable Development Goals, and studies have proposed various strategies to achieve this goal. However, few have examined the role of smartphone use in empowering women in decision‐making and its mechanism. Therefore, this study analyzes how smartphone use affects women's decision‐making power and explores whether this influence is due to women's off‐farm employment mechanisms. For this purpose, the study uses the survey data of 1110 households in rural China and the endogenous treatment regression model for analysis. The control function approach addresses the selection bias of off‐farm employment. The results show that smartphone use significantly increases women's decision‐making power, partially channeled through increasing women's off‐farm employment. The mechanism effect is robust to using both binary and intensive measurements of off‐farm employment. Therefore, a policy to improve access to internet facilities and smartphone use could improve women's decision‐making power through employment in the off‐farm sector.
Novel cell culture system for monitoring cells during continuous and variable negative‐pressure wound therapy
Authors: Yamashiro Toshifumi , Kushibiki Toshihiro , Mayumi Yoshine , Tsuchiya Masato , Ishihara Miya , Azuma Ryuichi 
Published: December 2022

AbstractBackgroundAlthough the clinical efficacy of negative‐pressure wound therapy (NPWT) is well known, many of its molecular biological mechanisms remain unresolved, mainly due to the difficulty and paucity of relevant in vitro studies. We attempted to develop an in vitro cell culture system capable of real‐time monitoring of cells during NPWT treatment.Materials and methodsA novel negative‐pressure cell culture system was developed by combining an inverted microscope, a stage‐top incubator, a sealed metal chamber for cell culture, and an NPWT treatment device. Human keratinocytes, PSVK‐1, were divided into ambient pressure (AP), continuous negative‐pressure (NPc), and intermittent negative‐pressure (NPi) groups and cultured for 24 h with scratch assay using our real‐time monitoring system and device. Pressure inside the device, medium evaporation rate, and the residual wound area were compared across the groups.ResultsPressure in the device was maintained at almost the same value as set in all groups. Medium evaporation rate was significantly higher in the NPi group than in the other two groups; however, it had negligible effect on cell culture. Residual wound area after 9 h evaluated by the scratch assay was significantly smaller in the NPc and NPi groups than in the AP group.ConclusionWe developed a negative‐pressure cell culture device that enables negative‐pressure cell culture under conditions similar to those used in clinical practice and is able to monitor cells under NPWT. Further experiments using this device would provide high‐quality molecular biological evidence for NPWT.
Mapping the food environment: The reliability of volunteered geographical information and institutional data sources in France
Authors: Vonthron Simon , Perrin Coline , Soulard Christophe‐Toussaint 
Published: December 2022

AbstractThe obesity epidemic and inequalities in access to food are prompting increasing numbers of food environment studies, which rely on secondary data sources for mapping. This article assesses the reliability of the two main food outlet data sources in France: the volunteered geographical information (VGI) collaborative map OpenStreetMap (OSM) and the national business register Sirene. Their information on food outlets was assessed through ground‐truthing in the city‐region of Montpellier. Sensitivity, positive predictive value, and concordance were computed for each database. We analyzed the socio‐spatial variability of these measures according to households' income level. The sensitivity of Sirene is good and that of OSM moderate, while the opposite holds for positive predictive value, and the concordance of both OSM and Sirene is fair. Sirene provides more reliable data on deprived neighborhoods and OSM on wealthy neighborhoods. Caution is recommended regarding the classifications on which they are based, the time required to update the institutional database, and socially influenced contributions to VGI.
Transcriptional changes in human palate and skin healing
Authors: Leonardo Trevor R. , Chen Lin , Schrementi Megan E. , Shi Junhe , Marucha Phillip T. , Glass Kimberly , DiPietro Luisa A. 
Published: December 2022

AbstractMost human tissue injuries lead to the formation of a fibrous scar and result in the loss of functional tissue. One adult tissue that exhibits a more regenerative response to injury with minimal scarring is the oral mucosa. We generated a microarray gene expression dataset to examine the response to injury in human palate and skin excisional biopsies spanning the first 7 days after wounding. Differential expression analyses were performed in each tissue to identify genes overexpressed or underexpressed over time when compared to baseline unwounded tissue gene expression levels. To attribute biological processes of interest to these gene expression changes, gene set enrichment analysis was used to identify core gene sets that are enriched over the time‐course of the wound healing process with respect to unwounded tissue. This analysis identified gene sets uniquely enriched in either palate or skin wounds and gene sets that are enriched in both tissues in at least one time point after injury. Finally, a cell type enrichment analysis was performed to better understand the cell type distribution in these tissues and how it changes over the time course of wound healing. This work provides a source of human wound gene expression data that includes two tissue types with distinct regenerative and scarring phenotypes.
Numerical Investigation on Natural Convection in Inclined Channels Partially Filled With Asymmetrically Heated Metal Foam
Authors: Andreozzi Assunta , Buonomo Bernardo , Jaluria Yogesh , Manca Oronzio 
Published: December 2022

Abstract
A numerical study on natural convection in an inclined channel partially filled with open metal foam is investigated in two-dimensional laminar and incompressible and steady-state condition. The upper wall is heated at uniform heat flux, and the lower wall is adiabatic. The governing equations for the metal foam are written assuming the Brinkman–Forchheimer-extended Darcy model and the local thermal equilibrium (LTE) hypothesis. The inclination angle with respect to the horizontal direction ranges between 0 deg and 90 deg. The metal foam structure is homogenous and isotropic and the thermophysical properties are assumed constant with the temperature. The main aim of the present study is to analyze the effect of inclination angle, pore density, and porosity to improve the knowledge on the thermal behaviors of natural convection in partially filled channel with metal foam. Moreover, this study aims to evaluate the possible improvement with respect to the clean inclined channel. Results are presented in terms of velocity and temperature fields, and both temperature and velocity profiles at different significant sections are shown, to obtain a description of the natural convection inside the inclined channel. Finally, average Nusselt number values are evaluated. The presence of metal foam affects the fluid flow in the channel with different motion behaviors. The heat transfer rate increases with the increase in inclination angle, and the average Nusselt number shows different trends for lower and higher Rayleigh numbers, Ra. A significant enhancement is detected for the higher Ra and it depends on the porosity and pore density.
Fasted Sprint Interval Training Results in Some Beneficial Skeletal Muscle Metabolic, but Similar Metabolomic and Performance Adaptations Compared With Carbohydrate-Fed Training in Recreationally Active Male
Authors: Aird Tom P. , Farquharson Andrew J. , Bermingham Kate M. , O’Sullivan Aifric , Drew Janice E. , Carson Brian P. 
Published: December 2022

Endurance training in fasted conditions (FAST) induces favorable skeletal muscle metabolic adaptations compared with carbohydrate feeding (CHO), manifesting in improved exercise performance over time. Sprint interval training (SIT) is a potent metabolic stimulus, however nutritional strategies to optimize adaptations to SIT are poorly characterized. Here we investigated the efficacy of FAST versus CHO SIT (4–6 × 30-s Wingate sprints interspersed with 4-min rest) on muscle metabolic, serum metabolome and exercise performance adaptations in a double-blind parallel group design in recreationally active males. Following acute SIT, we observed exercise-induced increases in pan-acetylation and several genes associated with mitochondrial biogenesis, fatty acid oxidation, and NAD+-biosynthesis, along with favorable regulation of PDK4 (p = .004), NAMPT (p = .0013), and NNMT (p = .001) in FAST. Following 3 weeks of SIT, NRF2 (p = .029) was favorably regulated in FAST, with augmented pan-acetylation in CHO but not FAST (p = .033). SIT induced increases in maximal citrate synthase activity were evident with no effect of nutrition, while 3-hydroxyacyl-CoA dehydrogenase activity did not change. Despite no difference in the overall serum metabolome, training-induced changes in C3:1 (p = .013) and C4:1 (p = .010) which increased in FAST, and C16:1 (p = .046) and glutamine (p = .021) which increased in CHO, were different between groups. Training-induced increases in anaerobic (p = .898) and aerobic power (p = .249) were not influenced by nutrition. These findings suggest some beneficial muscle metabolic adaptations are evident in FAST versus CHO SIT following acute exercise and 3 weeks of SIT. However, this stimulus did not manifest in differential exercise performance adaptations.
The Role of Integrated Approach in the Determination of Nanoparticle Sizes in Dispersions
Authors: Kuznetsova E. V. , Kuznetsov N. M. , Kalinin K. T. , Lebedev-Stepanov P. V. , Novikov A. A. , Chvalun S. N. 
Published: December 2022

Abstract
Aqueous dispersions of gold and silver nanoparticles (NPs) stabilized with sodium citrate, as well as polymeric NPs based on poly(lactide-co-glycolide) (70 : 30 mol %) stabilized with poly(vinyl alcohol) have been obtained. The sizes of NPs have been determined by transmission electron microscopy (TEM), dynamic light scattering (DLS), and analytical ultracentrifugation (AUC). It has been shown that the diameter of both metallic and polymeric particles measured by TEM is significantly lower than their hydrodynamic diameter Dh determined by DLS. Moreover, it has been found that the Dh value obtained for the studied particles from DLS distributions is overestimated compared to that determined by AUC, because the AUC method is less sensitive to the particle size polydispersity and the presence of large objects in a dispersion.
Status of cognitive frailty in elderly patients with chronic kidney disease and construction of a risk prediction model: a cross-sectional study
Authors: Luo Baolin , Luo Zebing , Zhang Xiaoyun , Xu Meiwan , Shi Chujun 
Published: December 2022

ObjectiveTo investigate the risk factors of cognitive frailty in elderly patients with chronic kidney disease (CKD), and to establish an artificial neural network (ANN) model.DesignA cross-sectional design.SettingTwo tertiary hospitals in southern China.Participants425 elderly patients aged ≥60 years with CKD.MethodsData were collected via questionnaire investigation, anthropometric measurements, laboratory tests and electronic medical records. The 425 samples were randomly divided into a training set, test set and validation set at a ratio of 5:3:2. Variables were screened by univariate and multivariate logistic regression analyses, then an ANN model was constructed. The accuracy, specificity, sensitivity, receiver operating characteristic (ROC) curve and area under the ROC curve (AUC) were used to evaluate the predictive power of the model.ResultsBarthel Index (BI) score, albumin, education level, 15-item Geriatric Depression Scale score and Social Support Rating Scale score were the factors influencing the occurrence of cognitive frailty (p<0.05). Among them, BI score was the most important factor determining cognitive frailty, with an importance index of 0.30. The accuracy, specificity and sensitivity of the ANN model were 86.36%, 88.61% and 80.65%, respectively, and the AUC of the constructed ANN model was 0.913.ConclusionThe ANN model constructed in this study has good predictive ability, and can provide a reference tool for clinical nursing staff in the early prediction of cognitive frailty in a high-risk population.