bluuebunny/crossref_metadata_2025_split huggingface dataset:
A spatial contextual immune genetic algorithm to building cartographic displacement
Authors: Liu Yuangang , Zhang Min , Li Shaohua , Yang Shuai , Dong Fang 
Published: May 2023

AbstractIn map generalization, displacement is the most frequently used operator to reduce the proximity conflicts caused by reducing scales or other generalization operations. Building displacement can be formalized as a combinatorial optimization problem, and a heuristic or intelligent search algorithm can be borrowed to obtain the solution. In this way, we can explicitly resolve minimum distance conflicts and control positional accuracy during the displacement. However, maintaining spatial relations and patterns of buildings can be challenging. To address spatial conflicts as well as preserve the significant spatial relations and patterns of buildings, we propose a new spatial contextual displacement algorithm based on an immune genetic algorithm. To preserve important spatial relations and global patterns of map objects and avoid topology errors, displacement safety zones are constructed by overlapping the Voronoi tessellation and buffer areas of the buildings. Additionally, a strategy to shift the buildings in a building group synchronously is used to maintain local building patterns. To demonstrate the effectiveness of our algorithm, two data sets with different building densities were tested. The results indicate that the new algorithm has obvious advantages in preventing topology errors and preserving spatial relations and patterns.
Conspiracy Theory as Individual and Group Behavior: Observations from the Flat Earth International Conference
Authors: Fernbach Philip M. , Bogard Jonathan E. 
Published: May 2023

AbstractConspiratorial thinking has been with humanity for a long time but has recently grown as a source of societal concern and as a subject of research in the cognitive and social sciences. We propose a three‐tiered framework for the study of conspiracy theories: (1) cognitive processes, (2) the individual, and (3) social processes and communities of knowledge. At the level of cognitive processes, we identify explanatory coherence and faulty belief updating as critical ideas. At the level of the community of knowledge, we explore how conspiracy communities facilitate false belief by promoting a contagious sense of understanding, and how community norms catalyze the biased assimilation of evidence. We review recent research on conspiracy theories and explain how conspiratorial thinking emerges from the interaction of individual and group processes. As a case study, we describe observations the first author made while attending the Flat Earth International Conference, a meeting of conspiracy theorists who believe the Earth is flat. Rather than treating conspiracy belief as pathological, we take the perspective that is an extreme outcome of common cognitive processes.
What the Acute Stress Response Suggests about Memory
Authors: Thomas Ayanna K. , Wulff Alia N. 
Published: May 2023

AbstractResearch suggests that stress has immediate and long‐term effects on attention and memory. Rather than disrupting memory formation and consolidation, acute stress has been shown to shift attention processes resulting in a tradeoff between prioritized and nonprioritized information. Both arousal and stress result in cognitive and neurobiological shifts that often support memory formation. When an acute stressor occurs, it can distort immediate attentional focus, increasing processing for high‐priority features while reducing processing for extraneous features. The downstream cognitive consequences for this shift in attention are better memory for some features and poorer memory for others when compared to conditions of low stress. However, individual differences (e.g., sex, age, basal stress response, and stress reactivity) all impact the relationship between the acute stress response and memory. Although acute stress generally benefits memory formation, we suggest that forgetting and later recovery of stressful memories can better be understood by examining factors that influence the subjective experience of stress and stress reactivity.
Constraints on currency market movements – Implications for the RMB exchange rate regime
Authors: Liu Zhiyuan , Wang Peijie 
Published: May 2023

AbstractThis paper reveals the inherent characteristics behind the statistical phenomena of exchange rate interactions and co‐movements, corroborated empirically by exploring a range of currencies with varied degrees of flexibility. It then studies purposely the historical evolution and development prospects of the RMB exchange rate regime. The RMB exchange rate behaviour and statistical patterns are contrasted with the freely floating currencies in this context. Taking up alternative policy positions, the expected developments in RMB characteristics are deliberated, projecting a trajectory for further RMB regime reforms. How the RMB would fulfil the significant role on the global currency market as signified by its position in the SDR basket is contemplated, beyond a conventional policy shift and under the paradigm that the global currency market tends to be tri‐polar.
“In Soccer, We Have the Opportunity to Call Attention to Certain Things”: An Examination of Media Framing of Activism for Human Rights in German Sport
Authors: Kluch Yannick , Frederick Evan L. , Siegfried Nina 
Published: May 2023

The goal of this study was to extend the contemporary athlete activism literature by (a) exploring athlete activism beyond a strictly North American context and (b) examining how athlete activism at an organizational/institutional level (i.e., sport organization) may be framed differently than activist efforts at an individual level (i.e., athlete). By examining two examples of activism in German soccer, we show that the framing of both athlete-enacted and organization-enacted examples of activism highlighted the importance of speaking up when human rights are violated, called for the display of solidarity, and discussed the broader political implications for such protests. Additionally, framing of both examples of activism included voices of criticism regarding the sport organizations governing global sport. As calls for accountability of sport organizations suppressing athlete expression are becoming increasingly common in global sport, this study adds to a shifting focus of activism research targeting the sport institutions that often perpetuate the various injustices individual athletes call attention to.
Point-of-care ultrasound for tuberculosis diagnosis in children: a Médecins Sans Frontières cross-sectional study in Guinea-Bissau
Authors: Moretó-Planas Laura , Sagrado María José , Mahajan Raman , Gallo Jonathan , Biague Evelize , Gonçalves Ramiro , Nuozzi Pablo , Rocaspana Merce , Fonseca Jamila Vieira , Medina Candida , Camará Miguel , Nadimpalli Adi , Alonso Beatriz , Llosa Augusto E , Heuvelings Lotje , Burza Sakib , Molina Israel , Ruby Lisa C , Stratta Erin , Bélard Sabine 
Published: May 2023

ObjectiveDescription of tuberculosis (TB)-focused point-of-care ultrasound (POCUS) findings for children with presumptive TB.DesignCross-sectional study (July 2019 to April 2020).SettingSimão Mendes hospital in Bissau, a setting with high TB, HIV, and malnutrition burdens.ParticipantsPatients aged between 6 months and 15 years with presumptive TB.InterventionsParticipants underwent clinical, laboratory and unblinded clinician-performed POCUS assessments, to assess subpleural nodules (SUNs), lung consolidation, pleural and pericardial effusion, abdominal lymphadenopathy, focal splenic and hepatic lesions and ascites. Presence of any sign prompted a POCUS positive result. Ultrasound images and clips were evaluated by expert reviewers and, in case of discordance, by a second reviewer. Children were categorised as confirmed TB (microbiological diagnosis), unconfirmed TB (clinical diagnosis) or unlikely TB. Ultrasound findings were analysed per TB category and risk factor: HIV co-infection, malnutrition and age.ResultsA total of 139 children were enrolled, with 62 (45%) women and 55 (40%) aged <5 years; 83 (60%) and 59 (42%) were severely malnourished (SAM) and HIV-infected, respectively. TB confirmation occurred in 27 (19%); 62 (45%) had unconfirmed TB and 50 (36%) had unlikely TB. Children with TB were more likely to have POCUS-positive results (93%) compared with children with unlikely TB (34%). Common POCUS signs in patients with TB were: lung consolidation (57%), SUNs (55%) and pleural effusion (30%), and focal splenic lesions (28%). In children with confirmed TB, POCUS sensitivity was 85% (95% CI) (67.5% to 94.1%). In those with unlikely TB, specificity was 66% (95% CI 52.2% to 77.6%). Unlike HIV infection and age, SAM was associated with a higher POCUS-positivity. Cohen’s kappa coefficient for concordance between field and expert reviewers ranged from 0.6 to 0.9.ConclusionsWe found a high prevalence of POCUS signs in children with TB compared with children with unlikely TB. POCUS-positivity was dependent on nutritional status but not on HIV status or age. TB-focused POCUS could potentially play a supportive role in the diagnosis of TB in children.Trial registration numberNCT05364593.
Study protocol for the use of time series forecasting and risk analyses to investigate the effect of the COVID-19 pandemic on hospital admissions associated with new-onset disability and frailty in a national, linked electronic health data setting
Authors: Thomas Seth , Machuel Perrine , Foubert Josephine , Nafilyan Vahe , Bannister Neil , Colvin Helen , Routen Ash , Morriss Richard , Khunti Kamlesh , Farooqi Azhar , Armstrong Natalie , Gray Laura , Gordon Adam 
Published: May 2023

IntroductionOlder people were at particular risk of morbidity and mortality during COVID-19. Consequently, they experienced formal (externally imposed) and informal (self-imposed) periods of social isolation and quarantine. This is hypothesised to have led to physical deconditioning, new-onset disability and frailty. Disability and frailty are not routinely collated at population level but are associated with increased risk of falls and fractures, which result in hospital admissions. First, we will examine incidence of falls and fractures during COVID-19 (January 2020–March 2022), focusing on differences between incidence over time against expected rates based on historical data, to determine whether there is evidence of new-onset disability and frailty. Second, we will examine whether those with reported SARS-CoV-2 were at higher risk of falls and fractures.Methods and analysisThis study uses the Office for National Statistics (ONS) Public Health Data Asset, a linked population-level dataset combining administrative health records with sociodemographic data of the 2011 Census and National Immunisation Management System COVID-19 vaccination data for England. Administrative hospital records will be extracted based on specific fracture-centric International Classification of Diseases-10 codes in years preceding COVID-19 (2011–2020). Historical episode frequency will be used to predict expected admissions during pandemic years using time series modelling, if COVID-19 had not occurred. Those predicted admission figures will be compared with actual admissions to assess changes in hospital admissions due to public health measures comprising the pandemic response. Hospital admissions in prepandemic years will be stratified by age and geographical characteristics and averaged, then compared with pandemic year admissions to assess more granular changes. Risk modelling will assess risk of experiencing a fall, fracture or frail fall and fracture, if they have reported a positive case of COVID-19. The combination of these techniques will provide insight into changes in hospital admissions from the COVID-19 pandemic.Ethics and disseminationThis study has approval from the National Statistician’s Data Ethics Advisory Committee (NSDEC(20)12). Results will be made available to other researchers via academic publication and shared via the ONS website.
Protocol of a multicentre randomised controlled trial assessing transperineal prostate biopsy to reduce infectiouscomplications
Authors: Hu Jim , Zhu Alec , Vickers Andrew , Allaf Mohamad Ezzeddine , Ehdaie Behfar , Schaeffer Anthony , Pavlovich Christian , Ross Ashley E , Green David A , Wang Gerald , Ginzburg Serge , Montgomery Jeffrey S , George Arvin , Graham John N , Ristau Benjamin T , Correa Andres , Shoag Jonathan E , Kowalczyk Keith J , Zhang Tenny R , Schaeffer EM 
Published: May 2023

IntroductionApproximately one million prostate biopsies are performed annually in the USA, and most are performed using a transrectal approach under local anaesthesia. The risk of postbiopsy infection is increasing due to increasing antibiotic resistance of rectal flora. Single-centre studies suggest that a clean, percutaneous transperineal approach to prostate biopsy may have a lower risk of infection. To date, there is no high-level evidence comparing transperineal versus transrectal prostate biopsy. We hypothesise that transperineal versus transrectal prostate biopsy under local anaesthesia has a significantly lower risk of infection, similar pain/discomfort levels and comparable detection of non-low-grade prostate cancer.Methods and analysisWe will perform a multicentre, prospective randomised clinical trial to compare transperineal versus transrectal prostate biopsy for elevated prostate-specific antigen in the first biopsy, prior negative biopsy and active surveillance biopsy setting. Prostate MRI will be performed prior to biopsy, and targeted biopsy will be conducted for suspicious MRI lesions in addition to systematic biopsy (12 cores). Approximately 1700 men will be recruited and randomised in a 1:1 ratio to transperineal versus transrectal biopsy. A streamlined design to collect data and to determine trial eligibility along with the two-stage consent process will be used to facilitate subject recruitment and retention. The primary outcome is postbiopsy infection, and secondary outcomes include other adverse events (bleeding, urinary retention), pain/discomfort/anxiety and critically, detection of non-low-grade (grade group ≥2) prostate cancer.Ethics and disseminationThe Institutional Review Board of the Biomedical Research Alliance of New York approved the research protocol (protocol number #18-02-365, approved 20 April 2020). The results of the trial will be presented at scientific conferences and published in peer-reviewed medical journals.Trial registration numberNCT04815876.
Assessing discrepancies in estimates of road traffic deaths in Brazil
Authors: Bhalla Kavi , Job Soames , Mitra Sudeshna , Harrison James E , Mbugua Leah Watetu , Neki Kazuyuki , Gutierrez Hialy , Balasubramaniyan Ramshankar , Winer Mercer , Vos Theo , Hamilton Erin 
Published: May 2023

IntroductionThe First UN Decade of Action for Road Safety (2011–2020) ended with most low/middle-income countries (LMICs) failing to reduce road traffic deaths. In contrast, Brazil reported a strong decline starting in 2012. However, comparisons with global health statistical estimates suggest that official statistics from Brazil under-report traffic deaths and overestimate declines. Therefore, we sought to assess the quality of official reporting in Brazil and explain discrepancies.MethodsWe obtained national death registration data and classified deaths to road traffic deaths and partially specified causes that could include traffic deaths. We adjusted data for completeness and reattributed partially specified causes proportionately over specified causes. We compared our estimates with reported statistics and estimates from the Global Burden of Disease (GBD)-2019 study and other sources.ResultsWe estimate that road traffic deaths in 2019 exceeded the official figure by 31%, similar to traffic insurance claims (27.5%) but less than GBD-2019 estimates (46%). We estimate that traffic deaths have declined by 25% since 2012, close to the decline estimated by official statistics (27%) but much more than estimated by GBD-2019 (10%). We show that GBD-2019 underestimates the extent of recent improvements because GBD models do not track the trends evident in the underlying data.ConclusionBrazil has made remarkable progress in reducing road traffic deaths in the last decade. A high-level evaluation of what has worked in Brazil could provide important guidance to other LMICs.
An introduction to the chalk aquifers of northern Europe
Authors: West L. J. , Farrell R. P. , Foley A. E. , Howlett P. R. , Massei N. 
Published: May 2023

Abstract
We briefly outline the progressive development of approaches to both the characterization and simulation of the hydrogeology of northern European chalk aquifers, which were some of the first in the world to be studied. The volume's scope includes work on water resources and quality, chalk streams and wetland ecosystems, chalks as heat reservoirs for building temperature regulation, sources of groundwater flood risk and impacts of engineering on the subsurface, and diffuse and point-source pollution affecting these aquifers. It excludes hydrocarbon-related studies and those focused on offshore chalk sequences. We briefly outline the current state of knowledge of hydrogeological processes, characterization, assessment and modelling, and the increasingly recognized importance of karst features. The latter were little discussed 20 years ago and are still often neglected. There follows a brief quantitative analysis of publication topics relating to chalk hydrogeology in the scientific literature over the past three decades, which highlights key trends including both the purposes of studies and the methods employed. We present a summary of the topics and contributions within this volume, and conclude by identifying the key issues that need to be addressed in order to ensure the sustainability of our chalk aquifers for the future.
Experimental insight into basaltic andesite lava dome oxidation textures at La Soufrière, St Vincent
Authors: Morrison-Evans Beitris , Melekhova Elena , Blundy Jonathan 
Published: May 2023

Abstract
Petrological analysis of the 2020–21 La Soufrière lava dome reveals ubiquitous oxidation textures. Comparison of the natural dome rock to subsequent explosive scoria phases highlights the lack of any oxidation features in the latter, indicating that oxidation processes affected only the dome-forming magma, either during pre-eruptive storage or upon emplacement. To investigate the causes of oxidation we present a series of one-atmosphere experiments, using fresh natural basaltic andesite scoria as a starting material. Experiments were performed at 900 and 1020°C and at oxygen fugacities between NNO − 2 and air. Experimental results show that iron oxide nanolites nucleate on the rims of pyroxene microlites and phenocrysts under all experimental conditions except at NNO − 2. Orthopyroxene phenocrysts become unstable at 1020°C, at and above NNO + 2. Olivine symplectites form in all experiments at and above NNO. Titanomagnetite co-exsolves titanohematite and an Mg–Fe–Al spinel (pleonaste–magnesioferrite) at and above NNO + 2. Well-developed Mg–Fe–Al spinel trellis exsolution lamellae in titanomagnetite phenocrysts, as seen in the dome, only form in the presence of air at 900°C. The combination of textures and compositions observed in the natural dome indicates that oxidation of the dome magma occurred during emplacement at Earth's surface, with air percolating through the dome at temperatures ≤900°C.
The HDAC2-SP1 Axis Orchestrates Protumor Macrophage Polarization
Authors: Zheng Xiang , Sarode Poonam , Weigert Andreas , Turkowski Kati , Chelladurai Prakash , Günther Stefan , Kuenne Carsten , Winter Hauke , Stenzinger Albrecht , Reu Simone , Grimminger Friedrich , Stiewe Thorsten , Seeger Werner , Pullamsetti Soni Savai , Savai Rajkumar 
Published: May 2023

Abstract

Tumor-associated macrophages (TAM), including antitumor M1-like TAMs and protumor M2-like TAMs, are transcriptionally dynamic innate immune cells with diverse roles in lung cancer development. Epigenetic regulators are key in controlling macrophage fate in the heterogeneous tumor microenvironment. Here, we demonstrate that the spatial proximity of HDAC2-overexpressing M2-like TAMs to tumor cells significantly correlates with poor overall survival of lung cancer patients. Suppression of HDAC2 in TAMs altered macrophage phenotype, migration, and signaling pathways related to interleukins, chemokines, cytokines, and T-cell activation. In coculture systems of TAMs and cancer cells, suppressing HDAC2 in TAMs resulted in reduced proliferation and migration, increased apoptosis of cancer cell lines and primary lung cancer cells, and attenuated endothelial cell tube formation. HDAC2 regulated the M2-like TAM phenotype via acetylation of histone H3 and transcription factor SP1. Myeloid cell–specific deletion of Hdac2 and pharmacologic inhibition of class I HDACs in four different murine lung cancer models induced the switch from M2-like to M1-like TAMs, altered infiltration of CD4+ and CD8+ T cells, and reduced tumor growth and angiogenesis. TAM-specific HDAC2 expression may provide a biomarker for lung cancer stratification and a target for developing improved therapeutic approaches.

Significance:
HDAC2 inhibition reverses the protumor phenotype of macrophages mediated by epigenetic modulation induced by the HDAC2–SP1 axis, indicating a therapeutic option to modify the immunosuppressive tumor microenvironment.
Intermetastatic and Intrametastatic Heterogeneity Shapes Adaptive Therapy Cycling Dynamics
Authors: Gallaher Jill , Strobl Maximilian , West Jeffrey , Gatenby Robert , Zhang Jingsong , Robertson-Tessi Mark , Anderson Alexander R.A. 
Published: May 2023

Abstract

Adaptive therapies that alternate between drug applications and drug-free vacations can exploit competition between sensitive and resistant cells to maximize the time to progression. However, optimal dosing schedules depend on the properties of metastases, which are often not directly measurable in clinical practice. Here, we proposed a framework for estimating features of metastases through tumor response dynamics during the first adaptive therapy treatment cycle. Longitudinal prostate-specific antigen (PSA) levels in 16 patients with metastatic castration-resistant prostate cancer undergoing adaptive androgen deprivation treatment were analyzed to investigate relationships between cycle dynamics and clinical variables such as Gleason score, the change in the number of metastases over a cycle, and the total number of cycles over the course of treatment. The first cycle of adaptive therapy, which consists of a response period (applying therapy until 50% PSA reduction), and a regrowth period (removing treatment until reaching initial PSA levels), delineated several features of the computational metastatic system: larger metastases had longer cycles; a higher proportion of drug-resistant cells slowed the cycles; and a faster cell turnover rate sped up drug response time and slowed regrowth time. The number of metastases did not affect cycle times, as response dynamics were dominated by the largest tumors rather than the aggregate. In addition, systems with higher intermetastasis heterogeneity responded better to continuous therapy and correlated with dynamics from patients with high or low Gleason scores. Conversely, systems with higher intrametastasis heterogeneity responded better to adaptive therapy and correlated with dynamics from patients with intermediate Gleason scores.

Significance:
Multiscale mathematical modeling combined with biomarker dynamics during adaptive therapy helps identify underlying features of metastatic cancer to inform treatment decisions.