bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative Life Cycle Assessment and Exergy Analysis of Coal‐ and Natural Gas‐Based Ammonia Production
Authors: Çetinkaya Afşın Yusuf , Bilgili Levent , Kuzu S. Levent , Yılmaz Fatih 
Published: August 2023

AbstractA comprehensive life cycle assessment (LCA) analysis of ammonia production is presented, focusing on the comparison between natural gas‐based and coal‐based processes. Ammonia production is associated with high energy consumption and significant carbon dioxide (CO2) emissions. The objective of this research is to identify key processes and parameters within the ammonia synthesis industry and provide recommendations for cleaner and more sustainable development. Exergy analysis is performed to assess the efficiency of ammonia production technologies and determine optimal operating conditions. Natural gas‐based ammonia production has lower environmental impacts compared to coal‐based production in most categories, except for ionizing radiation. Natural gas, being a cleaner‐burning fossil fuel, produces fewer greenhouse gas emissions and other air pollutants. However, it is essential to address the issue of ionizing radiation in natural gas‐based processes. The potential for more efficient technologies and the importance of removing sulfur and other impurities during the production process to optimize catalyst performance are highlighted.
A Practical Nanoplasmonic SERS Substrate for Differential Diagnosis of Lung Normal and Cancer Cells through Multivariate Statistical Analysis
Authors: Abraham Bini , Emmanuel Neethu , Ajikumar Nandu , Pulassery Sanoop , Varghese Liya Elsa , Murali Vishnu Priya , Munnilath Arun , Maiti Kasutabh Kumar , Yoosaf Karuvath 
Published: August 2023

AbstractLung cancer ranks first for cancer‐related mortalities primarily due to late diagnosis. Though Surface‐Enhanced Raman spectroscopy (SERS) is a popular bioanalytical technique, its direct application to diagnosis is impeded by low data reproducibility. Colloidal nanoparticles suffer from SERS intensity fluctuations due to unavoidable aggregation, and Brownian and diffusion motions in biological samples. The processes for solid‐state SERS substrates are either sophisticated or difficult to reproduce. Herein, we revisit the well‐established thermal evaporation process for the easy and reproducible preparation of silver nanoparticles loaded SERS glass substrates. The static mode of thermal evaporation yielded closely packed and uniformly distributed silver nanoparticles. The properties of these nanoparticles are tuned for the best performance by controlling the thermal evaporation process. And SERS substrate exhibited a reasonably good enhancement factor of ~105 with uniformity and reproducibility <6 % RSD over a large area. It was utilized for label‐free SERS fingerprinting of lung adenocarcinoma cells A549 and normal lung fibroblast cells, WI‐38. The obtained data shows a slight distinction of Raman fingerprints in terms of certain biomolecules like nucleic acids, proteins, and lipids. Further multivariate statistical tools have been utilized which ensures a clear divergence between the cancerous cells and normal cells.
Safety, Tolerability, and Pharmacokinetics of Valemetostat Tablets and the Effect of Food on Valemetostat Pharmacokinetics in Healthy Subjects: Two Phase 1 Studies
Authors: Tachibana Masaya , Matsuki Shunji , Toyama Kaoru , Maekawa Yutaro , Fukae Masato , Shimizu Takako , Tsutsumi Junko , Shinohara Sayaka , Ishizuka Hitoshi 
Published: August 2023

AbstractValemetostat is an oral, selective inhibitor of enhancer of zeste homolog‐2 (EZH2) and EZH1. In a first‐in‐human phase‐1 trial, valemetostat capsules were well tolerated and clinically active in patients with relapsed/refractory non‐Hodgkin lymphoma. Subsequently, a film‐coated tablet formulation was developed for future clinical trials and commercialization. We report outcomes from 2 phase 1 trials in healthy Japanese participants, assessing the safety, tolerability, and pharmacokinetics (PK) of valemetostat tablets at single ascending doses (50, 100, and 200‐mg), the relative bioavailability between capsules and tablets, and the effect of food (high‐fat or low‐fat meals) on the PK of valemetostat tablets. In the ascending‐dose study, valemetostat maximum plasma concentration (Cmax) and area under the concentration–time curve (AUC) increased dose‐proportionally. Valemetostat plasma PK parameters were similar between the capsule and tablet formulations following a single 200‐mg dose. Administration of valemetostat, 200 mg after a meal, was associated with 50%‐60% lower Cmax, 30%‐50% lower AUC, and a median Tmax delay of 2.5‐3 hours relative to fasted administration. Valemetostat was well tolerated in healthy subjects; treatment‐emergent adverse events were mild (grade 1) in severity. Based on these trials, the tablet formulation of valemetostat is suitable for use in subsequent clinical trials and should be administered under fasted conditions to avoid a negative food effect.
Safety, Pharmacokinetics, and Pharmacodynamics of Subcutaneous Sibeprenlimab in Healthy Participants
Authors: Zhang Xiaoyan , Wang Yanlin , Yarbrough Jill , Mathur Mohit , Andrews Lee , Pereira Brian , Sloan Susan E. , Schachter Asher D. 
Published: August 2023

AbstractSibeprenlimab blocks the cytokine “A Proliferation‐Inducing Ligand” (APRIL), which may play a key role in immunoglobulin A nephropathy pathogenesis. A phase 1 study of subcutaneous (SC) sibeprenlimab evaluated preliminary safety, tolerability, pharmacokinetics, and pharmacodynamics in healthy participants. This was an open‐label, single‐ascending‐dose study. Twelve participants in each of 4 sequential dosing cohorts received 1 SC dose of sibeprenlimab (200 mg [1×1 mL injection], 400 mg [2×1 mL injections], 400 mg [1×2 mL injection], or 600 mg [1 mL+2 mL injections]) and underwent 16‐week follow‐up for adverse events, pharmacokinetics, and pharmacodynamics (serum APRIL, immunoglobulin [Ig] levels). Sibeprenlimab in single SC doses of 200‐600 mg was slowly absorbed into the systemic circulation, with a median time to maximum serum concentration of approximately 6‐10.5 days, and a mean elimination half‐life of approximately 8‐10 days. Serum APRIL, IgA, IgM, and, to a lesser extent, IgG decreased in a dose‐dependent and reversible manner. Maximal reduction in serum IgA was approximately 60% at the 400‐ and 600‐mg doses and 40% at 200 mg. Serum APRIL rapidly decreased to near the lower limit of quantification, and duration of suppression was dose‐dependent, with near complete suppression until weeks 4‐6 at the 400‐mg dose and week 8 at the 600‐mg dose. Adverse events occurred in 30/48 (62.5%) participants; none were serious or led to study discontinuation. Sibeprenlimab rapidly and sustainably reduced target APRIL and Ig biomarkers in a dose‐dependent and reversible manner, with acceptable preliminary safety and pharmacokinetics.
Insight into the Structure of MOF‐Containing Hybrid Polymeric Microspheres
Authors: Goliszek Marta , Kochaniec Maria , Podkościelna B. Beata 
Published: August 2023

AbstractPolymer science exploited metal organic frameworks (MOFs) for various purposes, which is due to the fact that these materials are ideal platforms for identifying design features for advanced functional materials. The mechanism of polymerization using MOFs, is still largely unexplored and the detailed characterization of both materials in essential to understand the important interactions between the components. In this work modern advanced research methods were used to investigate the properties of MOF‐containing hybrid polymeric microspheres. Hydrothermal conversion of CFA‐derived iron particles was used to obtain MOF nanostructures, which were then introduced to the structure of hybrid polymer microspheres based on ethylene glycol dimethylacrylate (EGDMA) and triethoxyvinylsilane (TEVS). Chemical structures were confirmed by ATR‐FTIR method. To provide information about the elemental composition of the tested materials and for the determination of chemical bonds present in the tested samples XPS method was applied. Morphology was studied using SEM microscopy, whereas porosity was investigated using ASAP technique. Swellability coefficients were determined using typical organic solvents and distilled water. Moreover, the ecological aspect concerning the use of fly ashes deserves to be emphasized.
Peri‐urban systems alter trophic niche size and overlap in sympatric coastal bird species
Authors: Lato Kimberly A. , Fuirst Matthew , Veit Richard R. , Thorne Lesley H. 
Published: August 2023

AbstractUrban habitats can create empty trophic niche space by providing abundant alternative dietary resources, allowing some generalist species to either shift or expand their trophic niches. Resulting changes to trophic niche size may consequently affect interspecific interactions and competition, although trophic impacts are less clear in peri‐urban systems, where both natural and urban resources are readily accessible to highly mobile species. We combined stable isotope (δ13C, δ15N, δ34S) data with GPS tracking of two sympatric coastal bird species (Larus argentatus, L. marinus) across four study sites on the east coast of the United States, ranging from a study site in New York City (the most populous city in the United States) to less‐urban sites off Massachusetts. We quantified the trophic niche size and trophic niche overlap in three‐dimensional isotopic space and assessed spatial overlap in foraging habitat between species at both peri‐urban and less‐urban study sites. We found that for both species, birds at peri‐urban study sites had significantly larger trophic niches than birds from the less‐urban sites. Furthermore, for study sites where both species occurred, we found that overlap in trophic niche space and foraging habitats between species was lower at the peri‐urban study site than at the less‐urban site. These results suggest that peri‐urban environments may facilitate trophic niche expansion and decrease niche overlap in mobile generalist species, contrasting with previous studies showing increased trophic niche overlap in more isolated urban populations. Following further analysis, we found that trophic niche expansion was facilitated by both within‐ and between‐individual differences in foraging strategies. We posit that peri‐urban environments, particularly along coastal areas, can reduce interspecific competition between sympatric species by providing access to a variety of natural and anthropogenic diet items, especially for highly mobile generalist consumers that can access both natural and urban foraging areas. Research assessing how and at what scale peri‐urban systems influence wildlife is key to understanding how further global urbanization will shape ecosystem structures.
Epigenetic profiling of the D4Z4 locus: Optimization of the protocol for studying DNA methylation at single CpG site level
Authors: Megalizzi Domenica , Trastulli Giulia , Caputo Valerio , Colantoni Luca , Caltagirone Carlo , Strafella Claudia , Cascella Raffaella , Giardina Emiliano 
Published: August 2023

AbstractThe alteration of epigenetic modifications, including DNA methylation, can contribute to the etiopathogenesis and progression of many diseases. Among them, facioscapulohumeral dystrophy (FSHD) is a muscular disorder characterized by the loss of repressive epigenetic features affecting the D4Z4 locus (4q35). As a consequence, these alterations are responsible for DNA hypomethylation and a transcriptional‐active chromatin conformation change that, in turn, lead to the aberrant expression of DUX4 in muscle cells. In the present study, methylation levels of 29 CpG sites of the DR1 region (within each repeat unit of the D4Z4 macrosatellite) were assessed on 335 subjects by employing primers designed for enhancing the performance of the assay. First, the DR1 original primers were optimized by adding M13 oligonucleotide tails. Moreover, the DR1 reverse primer was replaced with a degenerate one. As a result, the protocol optimization allowed a better sequencing resolution and a more accurate evaluation of DR1 methylation levels. Moreover, the assessment of the repeatability of measurements proved the reliability and robustness of the assay. The optimized protocol emerges as an excellent method to detect methylation levels compatible with FSHD.
Epilepsy classification using artificial intelligence: A web‐based application
Authors: Asadi‐Pooya Ali A. , Fattahi Davood , Abolpour Nahid , Boostani Reza , Farazdaghi Mohsen , Sharifi Mehrdad 
Published: August 2023

AbstractObjectiveThe purpose of the current endeavor was to evaluate the feasibility of using easily accessible and applicable clinical information (based on history taking and physical examination) in order to make a reliable differentiation between idiopathic generalized epilepsy (IGE) versus focal epilepsy using machine learning (ML) methods.MethodsThe first phase of the study was a retrospective study of a prospectively developed and maintained database. All patients with an electro‐clinical diagnosis of IGE or focal epilepsy, at the outpatient epilepsy clinic at Shiraz University of Medical Sciences, Shiraz, Iran, from 2008 until 2022, were included. The first author selected a set of clinical features. Using the stratified random portioning method, the dataset was divided into the train (70%) and test (30%) subsets. Different types of classifiers were assessed and the final classification was made based on their best results using the stacking method.ResultsA total number of 1445 patients were studied; 964 with focal epilepsy and 481 with IGE. The stacking classifier led to better results than the base classifiers in general. This algorithm has the following characteristics: precision: 0.81, sensitivity: 0.81, and specificity: 0.77.SignificanceWe developed a pragmatic algorithm aimed at facilitating epilepsy classification for individuals whose epilepsy begins at age 10 years and older. Also, in order to enable and facilitate future external validation studies by other peers and professionals, the developed and trained ML model was implemented and published via an online web‐based application that is freely available at http://www.epiclass.ir/f‐ige.
Predictors of malignant transformation in oral leukoplakia and proliferative verrucous leukoplakia: An observational prospective study including the DNA ploidy status
Authors: Pentenero Monica , Castagnola Patrizio , Castillo Faride Victoria , Isaevska Elena , Sutera Samuele , Gandolfo Sergio 
Published: August 2023

AbstractBackgroundThis prospective observational study investigated the determinants of malignant transformation (MT) in localized oral leukoplakia (OL) and proliferative verrucous leukoplakia (PVL).MethodsDemographic, clinical, histological, and DNA ploidy status data were collected at enrolment. Survival analysis was performed (MT being the event of interest).ResultsOne‐hundred and thirty‐three patients with OL and 20 patients with PVL entered the study over 6 years (mean follow‐up 7.8 years). The presence of OED, DNA ploidy, clinical presentation, and lesion site were associated with MT in patients with OL in a univariate analysis. In a multivariate model, OED was the strongest predictor of MT in patients with OL. Adding DNA ploidy increased the model's predictive power. None of the assessed predictors was associated with MT in patients with PVL.ConclusionsDNA ploidy might identify a subset OL with low risk or minimal risk of MT, but it does not seem to be a reliable predictor in patients with PVL.
Prevalence and associated factors of depression, anxiety, and stress among pregnant women in Herat, Afghanistan: A cross‐sectional study
Authors: Niazi Aziz‐ur‐Rahman , Alekozay Mina , Osmani Khadejah , Najm Abdul Fattah 
Published: August 2023

AbstractBackground and AimsPregnancy is an important and natural event in a woman's life. It represents a time of substantial social and bio‐psychological challenges for a pregnant woman that may increase vulnerability to emotional disturbances such as depression, anxiety, and stress (DAS). This study aims to assess the prevalence and associated factors of DAS among pregnant women in Herat city of Afghanistan.MethodsThis hospital‐based cross‐sectional study was conducted between July and November 2019, on 691 Dari‐speaking pregnant women aged 15‐49 years, who attended the antenatal clinic of Herat Razaei Maternity Hospital. The interview process involved the use of a structured questionnaire that collected data on sociodemographic characteristics of participants, as well as the validated Dari‐translated version of DASS‐42 questionnaire. A χ2 test was used to test for association between categorical data. Forward likelihood ratio was used to assess the strength of association between sociodemographic variables and DAS; independently. The significance level was set to 0.05 and the confidence interval to 95% in all statistical analyses. Statistical analyses were performed in IBM SPSS Statistics (version 27).ResultsThe mean age of participants was 26.17 ± 6.06. The overall prevalence of DAS among study participants were 42.8%, 40.0%, and 59.5%, respectively. Planning of current pregnancy, women's health, husband's health, women's nutrition, family support, husband's support, women's education, women's employment, and family economy were significantly associated with DAS, while gestational age was not significantly associated with DAS.ConclusionThe prevalence of DAS among pregnant women in Herat city of Afghanistan is very high. Considering scientific evidence on high prevalence and associated factors of DAS among pregnant women, policymakers, public health authorities, and medical practitioners must devote significant attention in reducing the magnitude of these mental disorders and/or reducing their impact on women, their families, and the society.
Corporate risk disclosure and firm value: UK evidence
Authors: Ibrahim Awad Elsayed Awad , Aboud Ahmed 
Published: August 2023

AbstractThis study examines the influence of risk disclosure (RD) in the annual reports on Firm Value (FV) in the UK context. Furthermore, it addresses the moderating role of the analyst information environment in shaping this relation. Our study distinguishes between favourable and unfavourable information and examines whether the different nature of risk information could affect the FV differently. Our study contributes to the existing literature by providing empirical evidence on the value relevance of the narrative risk information. In particular, using a sample of UK listed firms, we find a positive relation between risk information and FV. We also contribute to the dilemma of risk disclosure measurement by using four different RD proxies. Our study has important implications for academics, standard setters, investors and managers.
Circ_LDLR promotes the progression of papillary thyroid carcinoma by regulating miR‐1294/HMGB3 axis
Authors: Chen Guo , Han Pengli , Zhang Qingsong , Li Mingchuang , Song Ting , Chen Zheng , Zhao Yatong , Yin Detao , Lv Jing 
Published: August 2023

AbstractCircular RNAs (circRNAs) have been found to be associated with the development and progression of cancers including papillary thyroid carcinoma (PTC). Circ_LDLR has been reported to be highly expressed in PTC, but its underlying mechanism of action has not been fully elucidated. This study aimed to investigate the role of circ_LDLR in PTC. The expression of circ_LDLR, miR‐1294 and high mobility group box (HMGB) 3 was detected by quantitative real‐time polymerase chain reaction (qRT‐PCR). CCK‐8 assay and transwell assays were employed to value cell viability, invasion and migration abilities. Western blot assay was to detect HMGB3 protein expression. Luciferase reporter gene and pull down assay were used to validate the interaction between miR‐1294 and HMGB3 or circ_LDLR. Circ_LDLR showed high expression levels in PTC tissues and cells and knockdown of it inhibited the growth, invasion, and migration of PTC cells. In addition, miR‐1294 was considered as a downstream target of circ_LDLR, and inhibition of miR‐1294 partially reversed the inhibitory effects of circ_LDLR knockdown on PTC cells growth, invasion, and migration. More importantly, HMGB3 was identified as a downstream target of miR‐1294. Our findings suggest circ_LDLR may plays a promoting role in PTC by downregulating miR‐1294 and upregulating HMGB3 expression. Therefore, circ_LDLR may serve as a valuable prognostic biomarker and therapeutic target for PTC.
TMEM175 downregulation participates in impairment of the autophagy related lysosomal dynamics following neonatal hypoxic‐ischemic brain injury
Authors: Zhang Huiyi , Tian Ye , Yu Weiwei , Tong Dongyi , Ji Yichen , Qu Xinrui , Deng Tianjiao , Li Xinsheng , Xu Ying 
Published: August 2023

AbstractThe mechanism underlying long‐term cognitive impairment caused by neonatal hypoxic‐ischemic brain injury (HIBI) remains unclear. Autophagy is a closely related mechanism and may play a role in this process. We aimed to investigate the role of lysosomal transmembrane protein 175 (TMEM175) in the autophagy‐lysosome pathway in neonatal rats with HIBI. A neonatal rat model of HIBI was established, hypoxia was induced, followed by left common carotid artery ligation. Expression levels of TMEM175 and the corresponding proteins involved in autophagy flux and the endolysosomal system fusion process were measured. Rats were administered TMEM175 plasmid via intracerebroventricular injection to induce overexpression. Brain damage and cognitive function were then assessed. TMEM175 was downregulated in the hippocampal tissue, and the autophagy‐lysosome pathway was impaired following HIBI in neonatal rats. Overexpression of TMEM175 significantly mitigated neuronal injury and improved long‐term cognitive and memory function in neonatal rats with HIBI. We found that improvement in the autophagy‐lysosome pathway and endolysosomal system homeostasis, which are TMEM175 related, occurred via regulation of lysosomal membrane dynamic fusion. TMEM175 plays a critical role in maintaining the autophagy‐lysosome pathway and endolysosomal homeostasis, contributing to the amelioration of neuronal injury and impaired long‐term cognitive function following neonatal HIBI.