bluuebunny/crossref_metadata_2025_split huggingface dataset:
Challenges and concerns in assisting indigenous people with suicide attempts
Authors: de Almeida Milena Nunes , Caixeta Camila Cardoso , Silva Nathalia dos Santos , de Morais Nathalia Martins , Santos Pâmela Damilano dos , Gonçalves Leandro Pires , Achatz Rafaela Waddington , Guimarães Danilo Silva , Chaudhary Nandita 
Published: July 2023

Abstract
There has been an alarming rise in suicide attempts among indigenous people in Brazil leading to national concerns about the provision of psychosocial care and professional support. In this study, we make an attempt to understand the perspectives of professionals in assisting indigenous people from a specific group, the Iny, and identify the specific challenges of addressing issues through the mental health care system, related specifically to suicide prevention. Using a qualitative approach with participant observation and semi-structured interviews, the research included indigenous and their families assisted by three public institutions, and the professionals that work in the public psychosocial assistance. For this paper we examined the tensions, conflicts and challenges of the health care professionals at one of these institutions, a Psychosocial Care Center in the state of Goiás/Brazil. For the analysis of data, a sociocultural protocol was built to identify dialogical tensions between the different thematic-fields of mental health care. The findings reveal that the theme of suicide was an important concern in the daily work with the community, but there were significant issues related to the assumptions, methodology and meaning of care between the professionals and the community on account of which the objective of the programme to address suicide attempts had not been effective or successful. The discussion of the results raises several critical questions about possible contributions of dialogical cultural psychology in the context of indigenous health, and also has important implications for the global issue of well-being of indigenous people.
Characterizing basalt-atmosphere interactions on Venus: A review of thermodynamic and experimental results
Authors: Filiberto Justin , McCanta Molly C. 
Published: July 2023

Abstract
The surface of Venus is in contact with a hot (~470 °C), high pressure (92 bars), and caustic (CO2 with S, but little H2O) atmosphere, which should cause progressive alteration of the crust in the form of sulfate and iron-oxide coatings; however, the exact rate of alteration and mineral species are not well constrained. Different experimental approaches, each with its own limitations, are currently being used to constrain mineralogy and alteration rates. One note is that no experimental approach has been able to fully replicate the necessary conditions and sustain them for a significant length of time. Furthermore, geochemical modeling studies can also constrain surface alteration mineralogy, again with different assumptions and limitations. Here, we review recent geochemical modeling and experimental studies to constrain the state of the art for alteration mineralogy, rate of alteration, open questions about the surface mineralogy of Venus, and what can be constrained before the fleet of missions arrives later this decade.
Combining the new results confirms that basalt on the surface of Venus should react quickly and form coatings of sulfates and iron-oxides; however, the mineralogy and rate of alteration are dependent on physical properties of the protolith (including bulk composition, mineralogy, and crystallinity), as well as atmospheric composition, and surface temperature. Importantly, the geochemical modeling results show that the mineralogy is largely controlled by atmospheric oxygen fugacity, which is not well constrained for the near-surface environment on Venus. Therefore, alteration experiments run over a range of oxygen and sulfur fugacities are needed across a wide range of Venus analog materials with varying mineralogy and crystallinity.
Evaluating the strictest water resources management policy in China based on the S-CAD method
Authors: Zhao Yuntong , Ouyang Rulin , Zhu Yixin , Wang Huanming , Cheng Zhe 
Published: July 2023

Abstract
The strictest water resources management (SWRM) policy is an important policy to promote the rational use of water resources and sustainable water development in China. An evaluation of the SWRM policy is conducive to the SWRM's optimization and water governance. The S-CAD (Subjectivity – Consistency, Adequacy, Dependency) method is used to assess the implementation effect and formulation of the SWRM policy. The results show that the SWRM policy has a clear logic, goals, and strategy; the goals reflect the government's policy stands and the policy goals can be fully realized through the implementation process. In addition, the SWRM policy's effect is high, which helps solve the challenges of maintaining water resources, the water environment, and water security in China, and has a positive impact on water use efficiency. This study enriches the knowledge body of water policy evaluation and water governance both in China and across the world
A hydrogeochemical study of groundwater of district Ballia, U.P., India
Authors: Verma Sumant Kumar , Chaurasia ShriRam 
Published: July 2023

Abstract

Arsenic is naturally found in the rocks of the Pleistocene and Holocene ages in the groundwater aquifer media. The district Ballia has many reports which are focused on arsenic contamination in its different blocks. This article is devoted to a thorough study of hydrogeochemical characteristics and the source of origin of arsenic in the groundwater system of the Ballia district. The relationship between this hydrogeologically present arsenic and various cations and anions including some physicochemical parameters are discussed here. These observations have been done using ICP MS and ion chromatographic techniques. The relationship study has been done by using a correlation matrix which is further proven by the dendrogram. Different types of loading plots of various principal components have also been studied with the help of principal component analysis. The nature and quality of groundwater are studied with the help of a piper plot. This research article is a complete and detailed study of the nature of groundwater in district Ballia. It also enlightens the source of arsenic contamination in the study area.
The Beneficial Effects of Curcumin on Lipids: Possible Effects on Dyslipidemia-induced Cardiovascular Complications
Authors: Yaribeygi Habib , Maleki Mina , Butler Alexandra E. , Jamialahmadi Tannaz , Gumpricht Eric , Sahebkar Amirhossein 
Published: July 2023

:
Dyslipidemia and altered lipid metabolism are closely involved in the pathogenesis
and clinical manifestation of many metabolic and non-metabolic diseases. Therefore,
mitigation of pharmacological and nutritional factors together with lifestyle modifications
is paramount. One potential nutraceutical exhibiting cell signaling and lipid-modulating
properties implicated in dyslipidemias is curcumin. Specifically, recent evidence
suggest that curcumin may improve lipid metabolism and prevent dyslipidemia-induced
cardiovascular complications via several pathways. Although the exact molecular mechanisms
involved are not well understood, the evidence presented in this review suggests
that curcumin can provide significant lipid benefits via modulation of adipogenesis and
lipolysis, and prevention or reduction of lipid peroxidation and lipotoxicity via different
molecular pathways. Curcumin can also improve the lipid profile and reduce dyslipidemia-
dependent cardiovascular problems by impacting important mechanisms of fatty acid
oxidation, lipid absorption, and cholesterol metabolism. Although only limited direct supporting
evidence is available, in this review we assess the available knowledge regarding
the possible nutraceutical effects of curcumin on lipid homeostasis and its possible impacts
on dyslipidemic cardiovascular events from a mechanistic viewpoint.
Synthetic and Clinical Perspectives of Evotaz: An Overview
Authors: Puri Sachin , Yadav Tanuja T. , Chouhan Mangilal , Kumar Kapil 
Published: July 2023

Abstract:
Viruses cause a variety of diseases in the human body. Antiviral agents are used to prevent
the production of disease-causing viruses. These agents obstruct and kill the virus's translation
and replication. Because viruses share the metabolic processes of the majority of host cells, finding
targeted medicines for the virus is difficult. In the ongoing search for better antiviral agents, the
USFDA approved EVOTAZ, a new drug discovered for the treatment of Human Immunodeficiency
Virus (HIV). It is a once-daily (OD) fixed-dose combination of Cobicistat, a cytochrome P450
(CYP) enzyme inhibitor, and Atazanavir, a protease inhibitor. The combination drug was created in
such a way that it can inhibit both CYP enzymes and proteases at the same time, resulting in the
virus's death. The drug is not effective in children under the age of 18; however, it is still being studied
for various parameters. This review article focuses on EVOTAZ's preclinical and clinical aspects,
as well as its efficacy and safety profiles.
Nanotechnology-based Drug Delivery for Alzheimer's and Parkinson's
Diseases
Authors: Nguyen-Thi Phuong-Trang , Ho Thanh-Tam , Nguyen Thuy Trang , Vo Giau Van 
Published: July 2023

Abstract:
The delivery of drugs to the brain is quite challenging in the treatment of the central nervous
system (CNS) diseases due to the blood-brain barrier and the blood-cerebrospinal fluid barrier. However,
significant developments in nanomaterials employed by nanoparticle drug-delivery systems have
substantial potential to cross or bypass these barriers leading to enhanced therapeutic efficacies. Advances
in nanoplatform, nanosystems based on lipids, polymers and inorganic materials have been extensively
studied and applied in treating Alzheimer's and Parkinson's diseases. In this review, various
types of brain drug delivery nanocarriers are classified, summarized, and their potential as drug delivery
systems in Alzheimer's and Parkinson's diseases is discussed. Finally, challenges facing the clinical
translation of nanoparticles from bench to bedside are highlighted.
Synthesis and Molecular Docking Study of Some New Thiazole-coumarin
Molecular Hybrids as Antibacterial Agents
Authors: Al-Humaidi Jehan Y. , Gomha Sobhi M. , Abdelrazek Fathy M. , Abdel-aziz Hassan M. , Abdelmonsef Aboubakr H. 
Published: July 2023

Background:
The emergence of drug-resistant bacteria and multidrug-resistant diseases, both of which are associated with high mortality, has posed a serious global health issue. Thiazoles and coumarins were reported as antimicrobial agents.

Objective:
This research paper aims to describe the synthesis of some novel thiazole derivatives bearing a coumarin residue as antibacterial agents

Methods:
The thiazole - coumarin hybrids were synthesized starting from the condensation of 3-acetyl coumarin (1) hydrazine carbothioamide (2) or thisemicarbazide then reacting the resulting products with different p-substituted phenacyl bromides (4a-e), hydrazonoyl chlorides (8a-e), and (11). In vitro antibacterial activity was studied in this work. In addition, molecular docking studies for the new compounds have also been carried out to investigate the binding mode of actions against the target DNA gyrase B.

Results:
Some of the newly synthesized compounds such as compounds 10b, 7, and 6b showed pro-nounced activities against Gram (+ve) and Gram (-ve) bacteria compared to a reference antibacterial agent. Compounds 10b, 7, and 6b exhibited the best binding affinity against the target

Conclusion:
We could obtain a series of precious hitherto unknown thiazole derivatives with varied antibacterial activities from cheap laboratory-available starting material following rather simple envi-ronmentally friendly techniques avoiding the use of hazardous or heavy metal-containing catalysts.
Treatment Strategies for Cervical Cancer in Older Women: Challenges and
Advancements
Authors: Singh Arun Kumar , Sundram Sonali , Arya Hema , Vandana  , Malviya Rishabha 
Published: July 2023

Abstract:
Recent advances in brachytherapy (BT) and chemotherapy, as well as consensus statements
from several different organizations, were examined in this study as they pertain to the treatment
of locally advanced cervical cancer (LACC). Since patients undergoing intensive chemotherapy
before, during, and after radiation therapy (RT) experienced significant toxicities, it was decided that
no additional conventional therapeutic options should be pursued. The use of PET-CT and MRI in the
assessment of pelvic lymph nodes and bone marrow metastases improved pelvic RT planning. It can
be concluded from the findings of the study that by administering an integrated boost for metastatic
pelvic lymph nodes in IMRT followed by MRI-guided adaptive beam therapy, patients with LACC
may benefit from modern radiation therapy methods that treat bladder and rectum tissues while shortening
treatment times.
Menginisiasi desain kain Jumput- Batik khas Banyunibo
Authors: Mahirta  , Savitri Mimi , D.S. Nugrahani  , Arumdati Fayeza Saliz 
Published: July 2023

Community around Banyunibo temple has been trained to produce hand-painted batik for the last 5 years. This training have improved their skill, enabling them to produce real hand-painted batik. However, their products have not sold well, moreover during the pandemic era caused by Covid-19. After carried out interview and discussion in survey phase, it is known that the community has problem in marketing their hand-painted batik and wish to have unique Banyunibo batik product. Based on the condition, the community service team of Archaeology Department, Faculty of Cultural Sciences conduct a community empowerment program with an intention to help Banyunibo community in creating Banyunibo’s batik motifs inspired by the reliefs of Banyunibo temple, unique, and potentially sale well. This community service conducted using skill building and empowerment approach, with the purpose to create active and direct invlolvement of the community during the activity. Hand-stamp batik introduced as an alternative to produce a less-expensive batik than hand-painted batik, therefore can compete well in batik market. Relief-inspired motifs created through distortion and stylization from the original temple reliefs. These motifs, made by stamp application technique, is also combined with jumput technique, creating a unique jumput - batik product that hopefully can increase the buying power of Banyunibo’s batik.
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Komunitas pembuat batik di sekitar Candi Banyunibo telah dilatih membuat batik tulis sejak lima tahun terakhir. Hasil kegiatan tersebut telah meningkatkan keterampilan mereka dalam membuat produk batik tulis. Namun, daya jual batik produk mereka masih rendah di pasaran, terlebih lagi pada masa pandemi Covid-19. Setelah melakukan wawancara dan diskusi pada tahap survei, diketahui bahwa masyarakat memiliki kendala berupa kesulitan memasarkan batik tulis dan keinginan untuk memiliki batik khas Banyunibo. Berdasarkan keadaan tersebut, tim pengabdian kepada masyarakat Departemen Arkeologi UGM melakukan program pemberdayaan komunitas dengan pembinaan batik cap dan pembuatan motif batik khas Banyunibo yang terinspirasi dari relief pada Candi Banyunibo. Pengabdian masyarakat ini dilakukan menggunakan pendekatan berupa pendampingan dan pemberdayaan masyarakat dengan tujuan agar masyarakat dapat terlibat langsung dan aktif dalam pelaksanaan pendampingan ini. Batik cap sebagai alternatif diperkenalkan untuk menghasilkan batik yang tidak semahal batik tulis sehingga harganya dapat bersaing di pasaran. Motif inspirasi relief candi diciptakan melalui proses distorsi dan stilasi dari gambar asli relief candi. Motif batik yang dihasilkan dengan teknik cap tersebut juga dikombinasikan dengan teknik jumput sehingga menghasilkan motif khas Banyunibo yang diharapkan dapat meningkatkan daya jual dari batik Desa Banyunibo.
Glyceryl Trinitrate, a Vasodilating Drug Acts as an Antibiofilm Agent in Serratia marcescens
Authors: Al-Fayyadh Ziyad Hameed , Turki Ahmed Mohammed , Al-Mathkhury Harith 
Published: July 2023

Objectives: Serratia marcescens is a gram-negative pathogen of many species. The ability of S. marcescens to form biofilms and its potent innate resistance to antimicrobials and cleaning solutions are both essential for its pathogenicity and survival. The present study was conducted to investigate the effect of glyceryl trinitrate (GTN) on the biofilm of S. marcescens, as an alternative for antibiotic therapy.
Methods: Different specimens, including ear swabs, burns, mid-stream urine, wound swabs, and sputum, were collected from patients who were brought to Al-Ramadi Hospital, Iraq. All samples were cultured, and the colonies that were obtained were detected using the VITEK® 2 compact. The ability of biofilms to develop was examined using the microtiter plate technique. The bactericidal effectiveness of GTN was estimated by the broth microdilution technique. The presence of fimA and fimC in S. marcescens isolates was detected using the polymerase chain reaction (PCR) method. Quantitative real-time polymerase chain reaction (qRT-PCR) was used to assess the effect of GTN on fimA and fimC gene expression.
Results: The results demonstrated that GTN has no effect on S. marcescens growth; while its biofilm was significantly (p<0.05) influenced. Moreover, all S. marcescens isolates had fimA and fimC, and the presence of GTN reduced the expression of these genes.
Conclusion: The findings of this study reveal that GTN can act as a promising antibiofilm agent in reference to S. marcescens.
Chlorine dioxide solution in metastatic cancer: case series
Authors: Aparicio-Alonso Manuel , Torres-Solórzano Verónica 
Published: July 2023

Chlorine dioxide is a potent oxidant with in vitro anticancer
activity. Its precise mechanism of action has not been thoroughly
explored, but it is proposed that it acts through the redox imbalance of
cancer cells. Three patients were treated for metastatic cancer (kidney,
prostate and lymphoma), on a compassionate basis. We report lasting
tumor response with a combination of oral, enema and/or intravenous
chlorine dioxide, without side effects. The patients had refused
conventional chemotherapy, radiation therapy or immunotherapy. This
preliminary work suggest that chlorine dioxide and his free radicals
might be the mediators. Chlorine dioxide is both a promising and
unexpensive anticancer agent. Rigorous clinical trials are needed to
confirm these preliminary results.
Keywords: Chlorine dioxide solution, cancer, reactive oxygen
species, intermittent fasting, ketogenic diet
Qualidade de um estudo de impacto ambiental, por meio da aplicação do método de análise de Lee & Colley
Authors: Campagnaro Virgínia Hamer , Farias Luciana Aparecida , Candiani Giovano 
Published: July 2023

Projetos, atividades ou empreendimentos causadores de significativo impacto ambiental, devem ser licenciados por meio da Avaliação de Impacto Ambiental (AIA), a qual encontra-se vinculada à apresentação do Estudo de Impacto Ambiental (EIA). Uma crítica em relação ao EIA têm sido sua baixa qualidade. O objetivo desse trabalho foi avaliar a qualidade de um estudo de impacto ambiental, por meio da aplicação do método de análise de Lee & Colley. A partir da aplicação desse método, foi obtida a nota E para este EIA, caracterizando-o como insatisfatório, possuindo omissões e pontos inadequados significativos. A análise de Lee & Colley apresenta ao todo 73 critérios de análise, incluindo 4 áreas, 17 categorias e 52 subcategorias. Deste total, 73 itens (critérios) analíticos, 24 (cerca de 33%) receberam nota D, 22 (30%) obtiveram nota E e 6 (8%) tiveram nota F. Com isto, 71% dos itens do EIA avaliado foram considerados inadequados. A partir do presente trabalho, foi possível evidenciar que o EIA avaliado não apresenta qualidade satisfatória, dificultando o processo de licenciamento ambiental e a tomada de decisão sobre a viabilidade socioambiental do empreendimento em questão.
The Effect of Hydroponic Nutrient Sources and Planting Media Types on the Growth and Production of Chinese Kale (Brassica oleraceae L.)
Authors: Nafiah Octavia Zuhrotun , Nugrahani Pangesti , Makhziah Makhziah 
Published: July 2023

Kale is prospective for cultivation because they have a good market. In order to get optimal plant output when growing kale in a hydroponic system, care must be taken to employ AB Mix nutrients and specific planting media types. This study aim at obtaining the right combination of AB Mix nutrients and types of growing media on the yield and growth of Kale plants, which were grown on substrates hydroponic. The study was organized in a Randomized Complete Block Design, with three replicates and factorial arrangement. The first factor was the source of nutrition AB Mix i.e. Infarm, Growrich, and Purie Garden. The second factor was the type of planting media, including husk charcoal, cocopeat, and a mixture of cocopeat and husk charcoal (1:1). Results revealed that the combination treatment of AB Mix nutrients and types of growing media was statistically different on the leaf area. The best combination was between charcoal and Infarm. The source of nutrition AB Mix significantly affected plant growth parameters such as plant height, leaf area, and dry weight of root with Infarm was found to the best nutrient. The type of growing media did not significantly influence all the parameters observed. Interaction between the type of nutrient AB Mix and type of growing media on the leaf area parameter showed with the best result M2A2 (husk charcoal + Infarm) of 700,96 cm2 , but not significantly different from the other treatment. Keywords: AB Mix nutrient, Cocopeat, Husk charcoal, Kale
Development of E-Module Integrated STEM Approach to Improve Students' Critical and Creative Thinking Skills
Authors: Adha Tri Zeni , Asrizal Asrizal , Rahim Fanny Rahmatina 
Published: July 2023

The era of industrial revolution 4.0 aims to develop human resources who can discuss creatively and think critically. Teachers can take advantage of technological developments by designing e-modules that integrate with STEM approaches that improve students' critical and creative thinking skills. The purpose of this study was to determine the results of validation of integrated e-modules the STEM approach. This research belongs to the research and development that designs up to the demonstration test stage using a four-dimensional development model. The data collection tool used validation sheets. The data collection tool used validation sheets. The result obtained from the mean V is 0.68, which is within the valid category. Based on the results of the study, it was concluded that an integrated work and energy materials e-module using a STEM approach would be suitable for use in a Grade X physics class. The e-modules integrated with STEM approach will be further developed and used as standalone learning materials to overcome the challenges of Industrial Revolution 4.0. This enhances student ability to think critically and creatively, leading to meaningful learning