bluuebunny/crossref_metadata_2025_split huggingface dataset:
STABILITY OF OMEGA-3 COMPOUNDS COMPLEX WITH PPAR-γ RECEPTOR AS AN ANTI-OBESITY USING MOLECULAR DYNAMIC SIMULATION
Authors: MUSFIROH IDA , MEGAWATI GINNA , HERAWATI DEWI M. D. , IFAYA MUS 
Published: January 2023

Objective: Obesity is a major contributor to comorbid diseases based on low grade chronic inflammation. Omega-3 fatty acids have a role in inflammation so it is thought to prevent obesity. This study was conducted to analyze the stability of omega-3 fatty acids with the PPAR-γ receptor using molecular dynamic simulation to investigate the relationship of macromolecule interactions to biologically relevant as an obesity comorbid.
Methods: The methods consisted of ligand acquisition, molecular dynamic simulation, and analysis of dynamic molecular results using Gromacs 2016.3 software and the results of the MD analysis were carried out by simulating time with VMD software and graphing the results of MD data analysis using Microsoft Excel.
Results: The result showed that docosahexaenoic acid (DHA), docosapentaenoic acid (DPA), and heneicosapentaenoic acid (HPA) have good stability. Average RMSD values of DHA, DPA, and HPA were 0.347 Å, 0.464 Å, and 0.706 Å with similar pattern of fluctuation across the region. DHA forms a hydrogen bond to Tyr347 and Leu343. Meanwhile, DPA binds to Asn52 and HPA bind to Arg213. DHA, DPA, and HPA have an average SASA of 233.91 nm2, 231.47 nm2, and 225.52 nm2, respectively. DHA has the lowest total binding energy (-129.914 kJ/mol) compared to DPA (-102.018 kJ/mol) and HPA (-115.992 kJ/mol).
Conclusion: Based on the molecular dynamics simulation approach, omega-3 compounds, DHA, DPA, and HPA showed that DHA has good stability compared to DPA and HPA. DHA, DPA, and HPA can be used as lead drugs to bind to PPAR-γ receptors to prevent and treat obesity.
A SERIES OF SIMPLE DECONTAMINATION METHODS OF BACTERIAL FLORA FOUND ON MUSICAL WIND INSTRUMENTS
Authors: KUSUMA SRI AGUNG FITRI , SARI WAHYU PURWITA , RUSMIATI DEWI 
Published: January 2023

Objective: This study was aimed to compare the efficacy of cleaning techniques using hot water treatment soap containing 2% triclosan and chemical antiseptics in reducing the bacterial contamination observed on shared musical wind instruments.
Methods: The trumpet, mellophone, trombone, and tuba were evaluated in this study. To count the initial bacterial colonies on the instrument, the total amount of bacteria adhered to it was extracted using the swab procedure. The mouthpieces were immersed in hot water at a temperature of 100 °C for 5 min and then were soaked in soap that contained 2% triclosan to achieve the effect of decontamination. Then the survival colonies were counted. As a series of decontamination technique, this study also examined the disinfection ability of phenol, chloroxylenol, povidone-iodine, and 70% alcohol utilizing the Rideal Walker method.
Results: When compared to liquid soap (50.30-91.67%), the cleaning procedure that uses immersion in hot water of 100 °C for 5 min greatly lowers the quantity of bacteria (91.85-99.91%). However, due to their huge surface area, tuba mouthpieces were the most straightforward to sterilize using both techniques. The highest phenol coefficient value was shown by chloroxylenol; however, all tested disinfectants showed stronger antibacterial activity than 1% phenol.
Conclusion: The mouthpieces of shared wind instruments can be cleaned quickly, easily, and effectively by immersing them in hot water at a temperature of 100 °C for 5 min. However, chloroxylenol has the strongest ability to eradicate bacteria from the instrument's mouthpiece.
ANTIDIABETIC ACTIVITY OF NOVEL CHROMENE COMPOUND ISOLATED FROM PEPEROMIA PELLUCIDA L. KUNTH AND IN SILICO STUDY AGAINST DPP-IV, ALPHA-GLUCOSIDASE, ALPHA-AMYLASE, AND ALDOSE REDUCTASE FOR BLOOD GLUCOSE HOMEOSTASIS
Authors: SUSILAWATI YASMIWAR , MEGANTARA SANDRA , LEVITA JUTTI 
Published: January 2023

Objective: During the outbreak of COVID-19, diabetes mellitus (DM) and cardiovascular disease (CVD) become risk factors for severe adverse clinical outcomes in COVID-19 patients. DM is a complex metabolic disease originating from a process of requiring adequate insulin or due to insulin resistance. This in silico study reveals the molecular interaction of Peperochromene A ((S)-2-methyl-2-(4-methylpent-3-enyl)-6-(propan-2-ylidene)-3,4,6,7-tetrahydropyrano[4,3-g]chromen-9(2H)-one), a novel chromene compound isolated from Peperomia pellucida with four proteins involved in the homeostasis of blood glucose, namely dipeptidylpeptidase-IV (DPP-IV), α-glucosidase, α-amylase, and aldose reductase.
Methods: Molecular docking simulation of the ligands was performed by employing AutoDock 4.2 embedded in LigandScout at a certain position determined automatically by the program. The default parameters of the automatic settings were used to set the genetic algorithm parameters.
Results: Peperochromene A could interact with all four targets; however, it binds to alpha-glucosidase and α-amylase with Ki (inhibition constant) value better than that of acarbose, the enzymes’ known inhibitor. This chromene compound also reveals an inhibition constant to aldose reductase similar with that of the enzyme inhibitor.
Conclusion: The chromene isolated from Peperomia pellucida is the potential to be developed as an inhibitor of the proteins involved in the homeostasis of blood glucose; thus, it can be further explored for its antidiabetic activity.
Reliģisko organizāciju kontrole Latvijas PSR (1944–1985)
Authors:   Latvijas Universitāte, Hristenko Diāna , Tēraudkalns Valdis 
Published: January 2023

The article aims to outline and explain the state structures that affected Protestant and Roman Catholic churches in LSSR from 1944 to 1985 as interlocutors in state and church relations. The authors chose to analyse these denominations, since they all were confronted with similar policies in the Soviet state. On the basis of archive materials and other sources, the authors have explored the structure of control over religious organizations and the nature of these activities, their impact on religious life in the LSSR, starting from governing bodies of denominations down to local churches. State-church relationships in USSR were determined, first of all, by ideology. The formal framework was dictated by the constitution of the USSR and the decisions of the Central Committee of the Communist Party. Policies on state and church relationships were changing depending on the USSR’s internal and foreign policies, but their main goal – eradicating religion as a phenomenon – remained unchanged. The authors analysed the ways how the plenipotentiaries of the Council for the Affairs of Religious Cults Office (CARC) implemented the decisions of their Moscow-based leadership, as well as how they interacted with local municipalities (sometimes overturning their decisions). Formally, plenipotentiaries were subordinated to CARC, but on a day-to-day basis there was a complex symbiosis between the plenipotentiaries, local municipalities, and republican-level party and state structures. For the most part, Soviet officials had little orientation in legal matters affecting state-church relations (no surprise because until the 1960s many instructions of the CARC were classified), and the plenipotentiary’s office also served an educational function. Leaders of denominations were included in the scheme of control and restrictions – through them, the state carried out plans of closing congregations and other repressive actions. Thus, the state power implemented another goal – undermining the authority of church leaders in the eyes of believers.
Postteisms Džona Sponga teoloģijā: izcelsme un galvenie aspekti
Authors:   Latvijas Universitāte, Ņizins Pāvels 
Published: January 2023

This article reflects on John Spong’s post-theistic theology and classifies it. Furthermore, the article introduces the readers to the context in which John Spong lived and worked (the second half of the 20th century in the West), and examines the changes in theology during this time (revision of various traditional theologies, especially the re-evaluation of classical theism as a reaction to the Holocaust-induced and post-war crises in society). The roots of John Spong’s theology have also been listed and analysed. Mainly, his work was inspired by such thinkers as F. Schleiermacher, R. Bultmann, P. Tillich, D. Bonhoeffer, and J. Robinson. It turned out that Spong did not take the ideas of these thinkers literally but adapted them and shaped his own views. The article also provides a critique of the theological views of John Spong. It was found that John Spong predominantly used a narrow definition of theism and did not consider the broader possibilities of interpreting theism (open, personal theism, etc.). This is partly due to the polemical nature of his theology, meant for consumption by the wider public. His criticism was rightly directed at the simplistic vision characteristic of fundamentalism and conservative evangelicalism, but it excluded other explanations of theism.
Pengelolaan Keuangan Dan Pengembangan Usaha Pada Usaha Mikro Kecil Menengah: Studi Kasus Pada UMKM Oleh-Oleh Di Kawasan Wisata Anyer
Authors: Supriadi Adih , Arisondha Edy 
Published: January 2023

Penelitian ini bertujuan nntuk mengetahui pengelolaan keuangan yang diterapkan oleh UMKM Toko Oleh-oleh di Kawasan Wisata Anyer dan bagaimana perencanaan pengembangan usahanya. Metode yang digunakan adalah pendekatan kualitatif, teknik pengumpulan data berupa observasi dan wawancara terhadap objek yang dituju yaitu para pelaku UMKM toko oleh-oleh yang ada di Kawasan Wisata Anyer, sehinga data yang didapat berupa data primer, dan analisis data yang diterapkan berupa analisis SWOT yaitu dengan cara indentifikasi berbagai faktor secara sistematis untuk merumuskan strategi UMKM, didasarkan pada logika yang dapat memaksimalkan kekuatan (strengths) dan peluang (opportunities), namun secara bersamaan dapat meminimalkan kelemahan (weaknesses) dan ancaman (threats). Hasil yang didapat yakni pengelolaan keuangan yang diterapkan oleh UMKM Toko Oleh-oleh di Kawasan Wisata Anyer semuanya hampir sama mereka melakukan pencatatan keuangan secara manual dan sederhana, dicatat dalam buku biasa bahkan ada yang tidak dicatat, rekap pendapatan/omset dihitung setiap hari secara manual apa adanya dan berapa adanya dari uang yang didapat, serta pencatatan pengeluaranpun tidak dicatat hanya dihitung ketika melakukan pembelanjaan barang saja. Dalam pengembangan usaha ada beberapa cara yang mereka lalukan, seperti perluasan toko, memperbanyak tempat lokasi usaha/toko, memperbanyak barang dagangan, dan ada beberapa yang sudah melakukan penjualan online melalui bukalapak dan shoppe, dan teknis pembayaran banyak yang masih konvensional dengan cara bayar tunai, namun ada juga yang sudah menerapkan pembayaran online melalui Dana dan OVO.
Kewenangan Jaksa Melakukan Penyadapan Dalam Proses Peradilan Pidana
Authors: Jayanti Debby , Usman Usman , Sudarti Elly 
Published: January 2023

Undang-Undang Nomor 11 Tahun 2021 Tentang Perubahan Atas Undang-Undang Nomor 16 Tahun 2004 Tentang Kejaksaan Republik Indonesia merupakan payung hukum terbaru di lingkup Kejaksaan Republik Indonesia. Berlakunya Undang-Undang Kejaksaan baru memperluas kewenangan jaksa melakukan penyadapan dalam proses peradilan pidana. Penelitian ini bertujuan: (1) Untuk mengetahui dan menganalisis pengaturan kewenangan Jaksa melakukan penyadapan berdasarkan Undang-Undang Nomor 11 Tahun 2021 Tentang Perubahan Atas Undang-Undang Nomor 16 Tahun 2004 Tentang Kejaksaan Republik Indonesia; (2) Untuk mengetahui dan menganalisis pengaturan tentang penyadapan di masa mendatang dalam perspektif pembaharuan hukum pidana. Metode penelitian: tipe penelitian yang digunakan adalah penelitian yuridis normative dengan pendekatan perundang-undangan, pendekatan konsep .Analisis bahan hukum dilakukan dengan cara menginterpretasi, menilai dan membuat mengevaluasi undang-undang. Kesimpulan: Pengaturan kewenangan jaksa melakukan penyadapan Berdasarkan Undang-Undang Nomor 11 Tahun 2021 Tentang Perubahan Atas Undang-Undang Nomor 16 Tahun 2004 Tentang Kejaksaan Republik Indonesia belum diatur secara jelas, tidak detail, dan tidak terukur yang berakibat timbulnya ketidakpastian hukum, serta pengaturan tentang penyadapan di masa mendatang dalam perspektif pembaharuan hukum pidana harus diatur secara eksplisit dalam sebuah Peraturan Perundang-Undangan.
Beliefs Guru Pada Peningkatan Kemampuan Menulis Bahasa Inggris Siswa Melalui Media Digital
Authors: Jannah Lilik Uzlifatul , Isnawati Uzlifatul Masruroh 
Published: January 2023

Guru adalah sosok panutan untuk siswa. Keberadaannya di dunia pendidikan tidak bisa dipungkiri. Pendidikan sangat tergantung pada sosok yang satu ini,baik atau buruknya. Beliefs guru membentuk pemahaman bagaimana guru belajar mengajar, menciptakan pembelajaran yang bermakna bagi siswa sebagai pengajar. Selama pandemi Covid-19, pelaksanaan pembelajaran jarak jauh membuat siswa tidak antusias dan kurang memahami materi dan seringnya mereka menghabiskan waktu dengan gadget mereka. Pentingnya penelitian ini untuk meyakinkan setiap pendidik bahwa Beliefs guru merupakan solusi yang tepat untuk meningkatkan kemampuan menulis bahasa Inggris siswa melalui media digital. Tujuan dari penelitian ini adalah untuk mengetahui efektivitas Beliefs guru dalam meningkatkan ketrampilan menulis bahasa Inggris siswa melalui media digital. Pendekatan penelitian yang digunakan adalah metode eksperimen semu. Sampel untuk survey terdiri dari 32 siswa kelas 8A SMPN1 Tikung. Data penelitian dikumpulkan dengan menggunakan (1) angket (kuesioner); (2) pre-test; (3) perlakuan kelas; dan (4) post-test. Analisis data survey dengan pengujian ANOVA menggunakan SPSS. Hasil tes akan ditampilkan, apakah mencapai taraf signifikasi atau tidak. Penerapan beliefs terhadap kemampuan menulis bahasa Inggris siswa melalui media digital dapat (1) meningkatkan dan menarik minat siswa dalam pembelajaran menulis bahasa Inggris.
Pengaruh Struktur Modal, Kebijakan Dividen Terhadap Kinerja Perusahaan Dimoderasi oleh Ukuran Perusahaan: Study Pada Perusahaan BUMN Yang Terdaftar di BEI Tahun 2018-2020
Authors: Syafik Mohammad , Arif Rochman , Amrozi Akhmad Imam , Ambarrini Dyah Ayu 
Published: January 2023

Penelitian ini bertujuan untuk menganalisis pengaruh struktur modal, kebijakan dividen terhadap kinerja perusahaan yang dimoderasi oleh ukuran perusahaan. Sampel dalam penelitian ini adalah perusahaan – perusahaan BUMN yang terdaftar pada Bursa Efek Indonesia pada Tahun 2017-2019. Metode analisis data dalam penelitian ini menggunakan Moderating Regression Analysis menggunakan bantuan software STATA. Hasil penelitian menunjukan bahwa struktur modal berpengaruh positif secara signifikan terhadap kinerja perusahaan sedangkan kebijakan dividen tidak berpengaruh terhadap kinerja perusahaan. Untuk ukuran perusahaan memoderasi hubungan struktur modal dengan kinerja perusahaan, namun ukuran perusahaan memoderasi dengan hubungan yang negative pada kebijakan dividen terhadap kinerja perusahaan.
Hubungan Keterampilan Sosial dan Makna Hidup Dengan Keterlibatan Siswa Dalam Pembelajaran di SMA Negeri 8 Medan
Authors: Sihite Adriyani , Lubis Lahmudin , Haris Abdul 
Published: January 2023

Penelitian ini bertujuan untuk mengetahui Hubungan Keterampilan sosial dan Makna Hidup dengan keterlibatan siswa pada siwa SMA N 8 Medan . Keterampilan sosial adalah suatu bentuk kepribadian di mana individu dapat mengatasi permasalahan yang dihadapinya dengan tepat dan efektif. Makna Hidup adalah cara pandang seseorang terhadap kejadian atau pengalaman yang dialaminya secara positif. Keterlibatan siswa merupakan ketegangan emosional yang muncul dari peristiwa-peristiwa kehidupan di sekolah dan perasaan terancamnya keselamatan atau harga diri siswa. Hipotesis yang diajukan dalam penelitian ini yaitu Ada hubungan yang positif antara Keterampilan sosial dan Makna Hidup dengan keterlibatan siswa . Penelitian ini menggunakan pendekatan kuantitatif. Teknik simple sampling, sampel berjumlah 250 siswa. Metode pengambilan data menggunakan skala model likert. Penelitian ini menggunakan skala Keterampilan sosial dan Makna Hidup dan skala keterlibatan siswa . Metode analisis data regresi berganda. Berdasarkan analisis data yang dilakukan, maka di peroleh Rxy) = 0,790 dengan p = 0.000 < 0.050, denga BE% = 62,9%. Diketahui 37,1% yang mempengaruhi keterlibatan siswa. Dengan demikian maka hipotesis yang diajukan, dinyatakan diterima.
Pengaruh Teori Fraud Pentagon Terhadap Kecurangan Dalam Laporan Keuangan Dengan Komite Audit Sebagai Moderasi
Authors: Pickless Sabrina Angelica Anastasia , Nurdiansyah Dian Hakip 
Published: January 2023

Tulisan ini bermaksud untuk menelaah transaksi penipuan yang dideterminasi oleh fraud pentagon. Populasinya adalah perusahaan konstruksi yang tercatat di BEI tahun 2016 - 2018. Teknik sampling memakai sampel tertarget dan diperoleh 52 perusahaan dengan 156 unit analisis. Data dianalisis memakai analisis regresi logistik dengan IBM SPSS Ver.26. Temuan menunjukkan bahwa pertumbuhan perusahaan memiliki dampak positif pada kecurangan laporan keuangan. Sementara itu, efektivitas pengawasan, kualitas auditor eksternal, pengalaman direktur dan dualitas CEO tidak berpengaruh pada kecurangan laporan keuangan. Komite Audit telah secara signifikan mengurangi dampak pertumbuhan perusahaan, efektivitas pengawasan, dan pengalaman direktur atas penipuan laporan keuangan. Namun, Komite Audit belum mengurangi dampak kualitas auditor eksternal dan dualitas CEO pada akun penipuan. Tulisan ini menyimpulkan bahwa kecurangan akuntansi semakin tinggi ketika pertumbuhan perusahaan semakin tinggi. Komite Audit memitigasi dampak pertumbuhan perusahaan, efektivitas pengawasan dan pengalaman direktur atas kecurangan akuntansi.
Age at diagnosis of type 2 diabetes and depressive symptoms, diabetes-specific distress and self-compassion
Authors: Barker Mary M. , Davies Melanie J. , Zaccardi Francesco , Brady Emer M. , Hall Andrew P. , Henson Joseph J. , Khunti Kamlesh , Lake Amelia , Redman Emma L. , Rowlands Alex V. , Speight Jane , Yates Tom , Sargeant Jack A , Hadjiconstantinou Michelle 
Published: January 2023

<p> </p>
<p><em>Objective: To investigate </em>the association between age at diagnosis of type 2 diabetes and depressive symptoms, diabetes-specific distress, and self-compassion among adults with type 2 diabetes.</p>
<p><em>Research Design and Methods: This analysis used data from the </em>CODEC (Chronotype of Patients with Type 2 Diabetes and Effect on Glycaemic Control) cross-sectional study. Information was collected on depressive symptoms, diabetes-specific distress, and self-compassion, measured using validated self-report questionnaires, in addition to sociodemographic and clinical data. Multivariable regression models, adjusted for diabetes duration, sex, ethnicity, deprivation status, prescription of antidepressants (selective serotonin reuptake inhibitors), and BMI were used to investigate the association between age at diagnosis of type 2 diabetes and each of the three psychological outcomes.</p>
<p><em>Results: 706 participants were included; </em>64 (9.1%) were diagnosed with type 2 diabetes under the age of 40 years, 422 (59.8%) between 40-59 years, and 220 (31.2%) at 60 years or older. After adjustment for key confounders, including diabetes duration, younger age at diagnosis was significantly associated with higher levels of depressive symptoms (βadj: -0.18, 95% CI: -0.25 to -0.10, <em>p</em><0.01) and diabetes-specific distress (βadj: -0.03, 95% CI: -0.04 to -0.02, <em>p</em><0.01), and lower levels of self-compassion (βadj: 0.01, 95% CI: 0.00 to 0.02, <em>p</em><0.01). </p>
<p><em>Conclusions: Diagnosis of type 2 diabetes at a younger age is associated with lower psychological wellbeing, suggesting the need for clinical vigilance and the availability of age-appropriate psychosocial support.</em> </p>
Glucagon Prescribing and Costs Among U.S. Adults with Diabetes, 2011-2021
Authors: Herges Joseph R. , Galindo Rodolfo J. , Neumiller Joshua J. , Heien Herbert C. , Umpierrez Guillermo E. , McCoy Rozalina G. 
Published: January 2023

<p> </p>
<p>OBJECTIVE: To characterize contemporary trends in glucagon fill rates and expenditures in a nationwide cohort of adults with diabetes, overall and by key demographic and clinical characteristics.</p>
<p>RESEARCH DESIGN AND METHODS: In this retrospective cohort study, we examined 1) glucagon fill rates per 1000 person-years and 2) patient out-of-pocket and health plan costs per filled glucagon dose among adults with diabetes included in OptumLabs® Data Warehouse between January 1st, 2011, and March 31st, 2021.</p>
<p>RESULTS: The study population was comprised of 2,814,464 adults with diabetes with a mean age of 62.8 (SD, 13.2) years. The overall glucagon fill rate decreased from 2.91 to 2.28 per 1000 person-years (-22%) over the study period. Glucagon fill rates increased in groups at high risk for severe hypoglycemia; from 22.46 to 36.76 (+64%), from 11.64 to 16.63 (+43%) and 16.08 to 20.12 (+25%) among patients with type 1 diabetes, patients treated with short-acting insulin and those with history of severe hypoglycemia, respectively. White patients, women, higher income individuals, and commercially-insured patients had higher glucagon fill rates when compared to minorities, males, lower income individuals, and Medicare Advantage patients, respectively. Total cost per dosing unit increased from $157.97 to $275.32 (+74%) among commercial beneficiaries and from $150.37 to $293.57 (+95%) among Medicare Advantage beneficiaries. </p>
<p>CONCLUSIONS: Glucagon fill rates are concerningly low and declined between 2011 and 2021, though increased in appropriate subgroups with type 1 diabetes, using short-acting insulin, or a history of severe hypoglycemia. Fill rates were disproportionately low among minorities and low-income individuals. </p>
O conceito de coletividade de Anton Makarenko, em seu poema pedagógico
Authors: Bretas Silvana , Novaes Karla 
Published: January 2023

Trata-se de pesquisa bibliográfica que analisa o texto Poema pedagógico (1935), de Anton Makarenko, a fim de abordar o conceito de coletividade inscrito na experiência educacional da Colônia de Gorki, situada no longínquo e congelado território da então União das Repúblicas Socialistas Soviéticas (URSS). Makarenko, em seu texto narrativo, descreve vivências de suas práticas, após a Revolução Socialista, na colônia destinada à educação de jovens infratores. Para o educador, o coletivo se constrói na convivência diária entre educandos e educadores.
Que educação é pública? Análise preliminar do atendimento conveniado na educação infantil nas diferentes regiões administrativas brasileiras
Authors: Borghi Raquel , Bertagna Regiane 
Published: January 2023

Apresenta e discute dados referentes ao atendimento conveniado na educação infantil nas regiões administrativas brasileiras. Além do estudo bibliográfico sobre a temática, realizou-se um levantamento acerca do número de municípios brasileiros de cada estado da Federação com matrículas conveniadas de educação infantil por meio dos dados disponíveis no Fundo Nacional de Desenvolvimento da Educação (FNDE), referentes ao ano de 2013. O objetivo foi discutir a atuação do setor privado no atendimento da educação infantil. Os resultados evidenciam uma maior consolidação nas regiões Sudeste e Sul de uma política de conveniamento pautada em subsídios públicos ao setor privado e indicam a urgente necessidade de afirmação e luta por uma educação pública, laica e de qualidade para todos.