bluuebunny/crossref_metadata_2025_split huggingface dataset:
Defining and targeting tumor-associated macrophages in malignant mesothelioma
Authors: Wu Licun , Kohno Mikihiro , Murakami Junichi , Zia Amin , Allen Jonathan , Yun Hana , Chan Meilin , Baciu Cristina , Liu Mingyao , Serre-Beinier Veronique , De Palma Michele , Felley-Bosco Emanuela , Yeung Jonathan , Pugh Trevor J. , de Perrot Marc 
Published: February 2023

Defining the ontogeny of tumor-associated macrophages (TAM) is important to develop therapeutic targets for mesothelioma. We identified two distinct macrophage populations in mouse peritoneal and pleural cavities, the monocyte-derived, small peritoneal/pleural macrophages (SPM), and the tissue-resident large peritoneal/pleural macrophages (LPM). SPM rapidly increased in tumor microenvironment after tumor challenge and contributed to the vast majority of M2-like TAM. The selective depletion of M2-like TAM by conditional deletion of the Dicer1 gene in myeloid cells (D
−/−
) promoted tumor rejection. Sorted SPM M2-like TAM initiated tumorigenesis in vivo and in vitro, confirming their capacity to support tumor development. The transcriptomic and single-cell RNA sequencing analysis demonstrated that both SPM and LPM contributed to the tumor microenvironment by promoting the IL-2-STAT5 signaling pathway, inflammation, and epithelial–mesenchymal transition. However, while SPM preferentially activated the KRAS and TNF-α/NFkB signaling pathways, LPM activated the IFN-γ response. The importance of LPM in the immune response was confirmed by depleting LPM with intrapleural clodronate liposomes, which abrogated the antitumoral memory immunity. SPM gene signature could be identified in pleural effusion and tumor from patients with untreated mesothelioma. Five genes,
TREM2, STAB1, LAIR1, GPNMB
, and
MARCO
, could potentially be specific therapeutic targets. Accordingly, Trem2 gene deletion led to reduced SPM M2-like TAM with compensatory increase in LPM and slower tumor growth. Overall, these experiments demonstrate that SPM M2-like TAM play a key role in mesothelioma development, while LPM more specifically contribute to the immune response. Therefore, selective targeting of monocyte-derived TAM may enhance antitumor immunity through compensatory expansion of tissue-resident TAM.
The European migrant crisis in Polish parliamentary discourse
Authors: Klepański Jakub , Hartliński Maciej , Żukowski Arkadiusz 
Published: February 2023

AbstractThe European migrant crisis constitutes one of the greatest challenges of the second Decade of the 21st century. Controlled by the populist Law and Justice, the Polish government has been one of the few to oppose receiving refugees, although it is obliged to through the cooperation of EU states. The authors analyzed 852 parliamentary speeches of 24 Polish political leaders since 2011 to 2019. Considering the analysis results, it is possible to conclude that the more severe the crisis became, the more dynamically the number of reports on the migrant crisis increased in parliamentary discourse. The research confirms that the two biggest parties present dramatically disparate views on the issue. The study also confirms that the views and declarations of the analyzed political leaders are compatible with the views of their electorates.
Is the observable Universe consistent with the cosmological principle?
Authors: Kumar Aluri Pavan , Cea Paolo , Chingangbam Pravabati , Chu Ming-Chung , Clowes Roger G , Hutsemékers Damien , Kochappan Joby P , Lopez Alexia M , Liu Lang , Martens Niels C M , Martins C J A P , Migkas Konstantinos , Ó Colgáin Eoin , Pranav Pratyush , Shamir Lior , Singal Ashok K , Sheikh-Jabbari M M , Wagner Jenny , Wang Shao-Jiang , Wiltshire David L , Yeung Shek , Yin Lu , Zhao Wen 
Published: February 2023

AbstractThe cosmological principle (CP)—the notion that the Universe is spatially isotropic and homogeneous on large scales—underlies a century of progress in cosmology. It is conventionally formulated through the Friedmann-Lemaître-Robertson-Walker (FLRW) cosmologies as the spacetime metric, and culminates in the successful and highly predictive Λ-Cold-Dark-Matter (ΛCDM) model. Yet, tensions have emerged within the ΛCDM model, most notably a statistically significant discrepancy in the value of the Hubble constant,H0. Since the notion of cosmic expansion determined by a single parameter is intimately tied to the CP, implications of theH0tension may extend beyond ΛCDM to the CP itself. This review surveys current observational hints for deviations from the expectations of the CP, highlighting synergies and disagreements that warrant further study. Setting aside the debate about individual large structures, potential deviations from the CP include variations of cosmological parameters on the sky, discrepancies in the cosmic dipoles, and mysterious alignments in quasar polarizations and galaxy spins. While it is possible that a host of observational systematics are impacting results, it is equally plausible that precision cosmology may have outgrown the FLRW paradigm, an extremely pragmatic but non-fundamental symmetry assumption.
Exponential horn revisited: wave equation, normal modes and experimental measurements
Authors: Matar M , Parodi M A , Raviola L , Novara I , Vera F , Gómez B J , Roatta A , Repetto C E 
Published: February 2023

Abstract
In this work, a theoretical analysis is first presented to find the wave equation corresponding to the propagation of disturbances in the air contained inside a tube of variable cross section. In particular, the case of a tube with a circular cross section whose area varies exponentially as a function of the axial coordinate is studied. The hypotheses of the model used are discussed and the solutions of the wave equation obtained are presented. Secondly, and with the aim of validating the model used, measurements are made on a tube such as the one described, built using a 3D printer.
Geometric and electronic diversity of metal doped boron clusters
Authors: Chen Bole , He Kaihua , Dai Wei , Gutsev Gennady L , Lu Cheng 
Published: February 2023

Abstract
Being intermediate between small compounds and bulk materials, nanoparticles possess unique properties different from those of atoms, molecules, and bulk matter. In the past two decades, a combination of cluster structure prediction algorithms and experimental spectroscopy techniques was successfully used for exploration of the ground-state structures of pure and metal-doped boron clusters. The fruitfulness of this dual approach is well illustrated by the discovery of intriguing microstructures and unique physicochemical properties such as aromaticity and bond fluxionality for both boron and metal-doped boron clusters. Our review starts with an overview of geometrical configurations of pure boron clusters B
n
, which are presented by planar, nanotube, bilayer, fullerene-like and core–shell structures, in a wide range of n values. We consider next recent advances in studies of boron clusters doped with metal atoms paying close and thoughtful attention to modifications of geometric and electronic structures of pure boron clusters by heteroatoms. Finally, we discuss the possibility of constructing boron-based nanomaterials with specific functions from metal-boron clusters. Despite a variety of fruitful results obtained in numerous studies of boron clusters, the exploration of boron-based chemistry has not yet reached its peak. The intensive research continues in this area, and it should be expected that it brings exciting discoveries of intriguing new structures.
Theoretical investigation of the interaction of ultra-high intensity laser pulses with near critical density plasmas
Authors: Vladisavlevici I M , Vizman D , d’Humières E 
Published: February 2023

Abstract
A theoretical model of energy transfer from laser to particles in the ultra-high intensity regime of laser plasma interaction is proposed, assuming that most of the laser energy will be transferred to hot electrons. Varying the target density and thickness, the optimal parameters for the maximum conversion efficiency of the laser energy to particles are studied. Through 2D particle-in-cell simulations, the model is validated for a near-critical density plasma between

0.5
−
20

n

c

(where

n

c

=
1.1
⋅

10

21

cm−3 is the critical density for a laser wavelength of

λ
=
1

μ

m) irradiated by a laser pulse of intensity in the range 1020–1023 W cm−2 and the pulse duration in the range 6.5–100 fs. As an application to this model, laser ion acceleration is studied for a laser intensity of 1022 W cm−2 and a pulse duration of 20 fs. Based on the literature and new findings from our model, the optimum thickness for ion acceleration and the maximum ion energies for an expansion like mechanism are predicted. These results can be used for applications requiring high energy ions and for preparations of experiments at the Apollon and ELI laser facilities.
An alternative approach to study the phase transitions and stability Analysis of Kerr-Newman-Kasuya black hole
Authors: Chaudhary Shahid , Sultan Muhammad Danish , Rehman Atiq ur , Zaidi Syed Najaf Abbas , Ali H. Elhosiny 
Published: February 2023

Abstract
We present the alternative approach to study the thermodynamics of Kerr-Newman-Kasuya spacetime (rotating dyon black hole) through deflection angle. We first compute the deflection angle of the considered model by using the Gauss Bonnet theorem. After calculating the thermodynamical quantities, we observe that temperature fluctuations in the deflection angle can be used to deduce the stable and unstable phases. Then, looking into the Gibbs free energy optical dependency to the Hawking-Page transition. We demonstrate, among other things, that the transition between a large to a small black hole takes place at a particular deflection angle value. Moreover, we also observe that heat capacity against deflection angle plays a vital role in the local stability of the Kerr-Newman-Kasuya spacetime.
Synthesis of hematite (α-Fe2O3) nanoparticles by a liquid-phase microplasma-assisted electrochemical process for photocatalytic activity
Authors: Iqbal Tariq , Khan Muhammad Abdul Rauf , Batool Syeda Kanwal , Shafique M , Waheed Anjam , Wee M F Mohd Razip , Iqbal Qamar 
Published: February 2023

Abstract
Dye contamination is becoming a more significant environmental challenge with the development of the textile industry. Scientists from all over the world are working hard to create new, more efficient ways to reduce environmental pollution through environmentally friendly synthesis techniques. In this regard, hematite (α-Fe2O3) nanoparticles have been synthesized by the novel, quick, cheap, and environmentally safe microplasma technique for the photodegradation of rhodamine-B under direct Sunlight. Thus, the synthesized α-Fe2O3 nanoparticles were characterized by various characterization techniques such as x-ray diffraction (XRD), scanning electron microscope (SEM), Fourier transform infrared spectroscopy (FTIR), and ultraviolet-visible spectroscopy (UV–vis spectroscopy). The structural and optical properties were found to vary with changing precursor concentrations. We measured the photocatalytic decolorization efficiency of synthesized hematite (α-Fe2O3) nanoparticles for rhodamine-B dye under direct Sunlight. It was found that α-Fe2O3 nanoparticles exhibited a decolorization capability with 73.75% decolorization of the dye at the rate of 0.04305 g.mg−1.min−1 after 100 min of irradiation, exhibiting excellent performance to remove organic contaminants from wastewater.
Heat transfer analysis of a convective radiative porous moving longitudinal fin exposed to magnetic field by Adomian decomposition sumudu transform method
Authors: Pavithra C G , Gireesha B J , Keerthi M L 
Published: February 2023

Abstract
A massive number of engineering disciplines are concerned with the enhancement of heat exchange. In this regard, the present article focuses on thermal analysis of natural convection and radiation of a fractional ordered moving fin problem exposed to the magnetic field and also for the first time Adomian decomposition sumudu transform method (ADSTM) has been introduced to solve the energy balance equation comprising the Peclet number. The governing equations along with the corresponding boundary conditions were solved with the aid of ADSTM. The accuracy of the present work has been validated through comparison with the numerical results. ADSTM results are in good agreement with the existing numerical results. The effect of various parameters on the dimensionless temperature profile for different fractional values of

α

is discussed in graphical records. We found that the temperature distribution along the tip of the fin increases by 1.53% as the Peclet number increases by 400%, and the thermal gradient along the fin tip decreases by 15.09% as the Hartman number increases by 400%.
Wearable sweat biosensors on textiles for health monitoring
Authors: Shi Yuqing , Zhang Ziyu , Huang Qiyao , Lin Yuanjing , Zheng Zijian 
Published: February 2023

Abstract
With the rapid technological innovation in materials engineering and device integration, a wide variety of textile-based wearable biosensors have emerged as promising platforms for personalized healthcare, exercise monitoring, and pre-diagnostics. This paper reviews the recent progress in sweat biosensors and sensing systems integrated into textiles for wearable body status monitoring. The mechanisms of biosensors that are commonly adopted for biomarkers analysis are first introduced. The classification, fabrication methods, and applications of textile conductors in different configurations and dimensions are then summarized. Afterward, innovative strategies to achieve efficient sweat collection with textile-based sensing patches are presented, followed by an in-depth discussion on nanoengineering and system integration approaches for the enhancement of sensing performance. Finally, the challenges of textile-based sweat sensing devices associated with the device reusability, washability, stability, and fabrication reproducibility are discussed from the perspective of their practical applications in wearable healthcare.
Application and prospect of semiconductor biosensors in detection of viral zoonoses
Authors: Zheng Jiahao , Feng Chunyan , Qiu Songyin , Xu Ke , Wang Caixia , Liu Xiaofei , Lv Jizhou , Yu Haoyang , Wu Shaoqiang 
Published: February 2023

Abstract
The rapid spread of viral zoonoses can cause severe consequences, including huge economic loss, public health problems or even global crisis of society. Clinical detection technology plays a very important role in the prevention and control of such zoonoses. The rapid and accurate detection of the pathogens of the diseases can directly lead to the early report and early successful control of the diseases. With the advantages of being easy to use, fast, portable, multiplexing and cost-effective, semiconductor biosensors are kinds of detection devices that play an important role in preventing epidemics, and thus have become one of the research hotspots. Here, we summarized the advances of semiconductor biosensors in viral zoonoses detection. By discussing the major principles and applications of each method for different pathogens, this review proposed the directions of designing semiconductor biosensors for clinical application and put forward perspectives in diagnostic of viral zoonoses.
Advanced biosensing technologies for monitoring of agriculture pests and diseases: A review
Authors: He Jiayao , Chen Ke , Pan Xubin , Zhai Junfeng , Lin Xiangmei 
Published: February 2023

Abstract
The threat posed to crop production by pests and diseases is one of the key factors that could reduce global food security. Early detection is of critical importance to make accurate predictions, optimize control strategies and prevent crop losses. Recent technological advancements highlight the opportunity to revolutionize monitoring of pests and diseases. Biosensing methodologies offer potential solutions for real-time and automated monitoring, which allow advancements in early and accurate detection and thus support sustainable crop protection. Herein, advanced biosensing technologies for pests and diseases monitoring, including image-based technologies, electronic noses, and wearable sensing methods are presented. Besides, challenges and future perspectives for widespread adoption of these technologies are discussed. Moreover, we believe it is necessary to integrate technologies through interdisciplinary cooperation for further exploration, which may provide unlimited possibilities for innovations and applications of agriculture monitoring.
Time-of-flight based neutron background reduction in secondary-electron-bremsstrahlung imaging for in-vivo range verification of proton therapy: a Monte Carlo study
Authors: Yabe T. , Yamaguchi M. , Tsuda M. , Nagao Y. , Kawachi N. 
Published: February 2023

Abstract
In proton therapy, range verification is important to monitor the location of the Bragg peak within the patient’s body. Secondary-electron-bremsstrahlung (SEB) imaging is a promising method of proton range verification. Unfortunately, the SEB images measured by the dedicated gamma camera contain neutron-induced backgrounds as well as the SEB counts. To improve the accuracy of range verification in SEB imaging, we propose to apply a time-of-flight (TOF) method to reduce neutron background in measured images of SEB. The SEB and neutron generation and transport were calculated by a Monte Carlo simulation. Proton pencil beams were irradiated to a water phantom and then the time spectra and profiles of SEB and neutron were obtained by scoring on a detector. The total count of neutrons was approximately 10 times higher than that of SEB and increased with higher proton energy. The TOF method, selecting a time window for the TOF spectrum of SEB, reduced the neutron background by more than 97%. We concluded that the TOF methods can dramatically reduce neutron background and improve the accuracy of proton range verification in SEB imaging.
Semiempirical criterion for eliminating wraparound artifacts in single-grid-based phase-contrast X-ray imaging
Authors: Lee H. , Lee M. , Lim H. , Jeon D. , Kim W. , Cho H. 
Published: February 2023

Abstract
Single-grid-based phase-contrast X-ray imaging (SG-PCXI) is a non-interferometric method for the simultaneous retrieval of absorption, phase-contrast (differential), and dark-field images from a single exposure with a common X-ray grid using a spatial harmonic imaging (SHI) technique. However, the retrieved images are often distorted by the wraparound artifacts that are caused by the spectral overlap of adjacent harmonic peaks in the Fourier domain, resulting in the degradation of image quality. In this study, a semiempirical criterion required for eliminating wraparound artifacts in SG-PCXI was established by considering two constraints: one to resolve periodic grid strips by the system resolution to use the SHI technique, and the other to ensure that the spectral contents of adjacent harmonic peaks are separated (not overlapped) to the greatest possible extent during data processing. Further, we assumed that the system resolution can be experimentally determined as the spatial frequency at a 10% modulation transfer function. To verify the efficacy of the semiempirical criterion, we conducted an experiment using a table-top setup, which primarily comprised a microfocus X-ray source with a 20 μm focal spot size, X-ray grids with strip densities of 150, 200, and 254 lines/inch, and a CMOS flat-panel detector with a 49.5 μm pixel size. The experimental measurements of the wraparound artifacts in our system setup were in good agreement with the semiempirical criterion over the entire range of test conditions, thus verifying its efficacy for SG-PCXI. Accordingly, the semiempirical criterion established in this study will be useful for designing a wraparound artifact-free system layout in SG-PCXI.
Modern high-availability multi-stage power distribution system for the CMS phase-2 upgrade
Authors: Stachon K. , Dissertori G. , Gadek T. , Hansen M. , Lusin S. , Lustermann W. 
Published: February 2023

Abstract
The operation of CMS at the HL-LHC requires an upgrade of the readout electronics. These new modern micro-electronics require power at precise voltages between 1.2 V and 2.5 V. We will deliver this power using a 3-stage system, comprising AC-DC conversion to 380 V DC followed by radiation-tolerant 12 V DC-DC power converters feeding radiation-hard point-of-load DC-DC converter. We have studied an industrial 380 V AC-DC conversion system, featuring hot-swappable 3 kW power modules, stackable up to ∼1 MW system. Such systems are candidates for the first conversion step, feeding custom power supplies accepting 400 V DC input voltage. Our tests on one of the commercially available systems purchased from Eltek demonstrated that the system complied with our requirements, most notably in terms of maintainability, availability and power quality. A few measurement plots perceived by authors as particularly interesting are discussed in this contribution.
Numerical Evaluation of Thermal Performance of Two-Phased Closed Thermosyphon for Solar Applications
Authors: Ramlee Muhamad Fadhli , Ibrahim Adnan , Jarimi Hasila , Ramlee Noorliyana , Fazlizan Ahmad 
Published: February 2023

Abstract
A heat pipe is an effective passive heat transfer device with a highly efficient heat transfer rate and thermal conductivity through evaporating and condensing a working fluid circulating in a vacuum-sealed container. For solar applications, heat pipes are usually used in evacuated tube collectors (ETCs). However, the use of heat pipes in solar photovoltaic/thermal (PVT) collector is limited. Generally, a heat pipe composes of three sections: the evaporator section, the condenser section, and the adiabatic section. A wickless heat pipe, also known as a closed thermosyphon or gravitationally assisted heat pipe, relies on gravity to return the working fluid to the evaporator. Various parameters could greatly influence the thermal performance of wickless heat pipes such as initial volume filling ratio (VFR), inclination angle, inner diameter of the heat pipes, ratio of evaporator/diameter and type of working fluid used. In this study, 2D transient computational fluid dynamics (CFD) simulations were performed using ANSYS Fluent to simulate the two-phase flow (water/steam) and to study the effect of different parameters on the heat transfer processes of a two-phase closed thermosyphon (TPCT) to increase its thermal performance. The 2D CFD simulations using multiphase volume of fluid (VOF) with two Eulerian phases could replicate the mass and heat transfer processes in comparison with published experimental data. A good agreement can be observed between the present CFD study with the published data in comparing the temperature profiles and thermal performance of the heat pipe. The numerical simulation of the evaporation and condensation process indicated that the thermal performance and characteristics of the TPCT are influenced by certain key parameters. In the future, full-scale 3D CFD simulations are planned to be performed to evaluate the thermal performance of heat pipes for solar photovoltaic/thermal (PVT) applications.