bluuebunny/crossref_metadata_2025_split huggingface dataset:
Macroalgae As a Source of Food And Health For Coastal Communities in Moluccas Province
Authors: Tuaputty Hasan , Papilaya Pamela Mercy , Tuapattinaya Prelly , Parry Cornelia , Alimudi Saiful 
Published: January 2025

These various types of macroalgae have an important role in the lives of coastal communities as a source of nutritious food and also have ecological and biological functions in maintaining the stability of marine ecosystems and as a place to live and protect other biota. This group of macroalgae has economic potential, namely as food, raw materials in industry and health. To find out macroalgae as a source of food and health, a study was carried out using a collaborative experimental research approach in the F-MIPA Laboratory at Pattimura University and field surveys in various districts of Moluccas Province.Types of macroalgae consumed by people in Maluku Province include: Eucheuma conttonii, Gracilaria salicornia, Caulerpa lentillifera, Kappaphycus alvarezii, Gracilaria arcuate species. Of these 5 types of macroalgae, 4 species are red macroalgae class Rhodophycea and 1 species is green macroalgae class Chrorophycea. The results of proximate analysis show that macroalgae are consumed by the public. The highest carbohydrate content in the macrolaga Gracilaria arcuata was 2.1370%, the highest proteins content in the macroalgae Eucheuma conttonii was 0.9161%, the fat content in the macrogaze was highest in the Kappaphycus alvarezii type at 0.4053%, the highest ash content in the macroalgae was in the Eucheuma conttonii type at 5.8155%. The highest water content contained in various types of macroalgae in the macroalgae Caulerpa lentillifera was 93.5485%. There is a linear correlation between the knowledge of coastal communities in several districts of Maluku Province who consume macroalgae as a source of food and health, and the attitude of coastal communities towards cooking menus made from macroalgae. This is proven by the analysis results showing an R value of 2 = 0.779, which means there is a significant correlation between knowledge. and public attitudes about macroalgae as a source of food and health. The existence of this significant relationship is due to the influence of knowledge of 77.9% on the attitudes of people who consume macrolaga, and only 22.1% is influenced by other factors. The results of the analysis show that there is an influence of knowledge on people's attitudes about macrolags as a source of food and health. According to the results of the analysis, it shows a value of df = 44-43 = 1 with a value of F = 221,690 with a significance level of 000, <p 0.05, this means that there is The significant influence between people's knowledge and attitudes towards the food menu comes from various types of macroalgae.
PENINGKATAN HASIL BELAJAR SISWA DENGAN MENGGUNAKAN MODEL PEMBELAJARAN KOOPERATIF TIPE NUMBERED HEAD TOGETHER (NHT) PADA MATERI OPERASI BENTUK ALJABAR DI KELAS VII SMP NEGERI 41 MALUKU TENGAH
Authors: Lepith Gressia Claudia , Molle Juliana Selvina , Tamalene Hanisa 
Published: January 2025

Operasi bentuk aljabar merupakan salah satu materi yang penting diajarkan di SMP, karena pembelajaran aljabar sangat bermanfaat bagi siswa dalam memahami materi yang lain maupun konsep aljabar di jejang pendidikan yang lebih tinggi. Penelitian ini mengkaji bagaimana meningkatkan hasil belajar siswa dengan menggunakan model pembelajaran kooperatif tipe Numbered Head together ( NHT) pada materi operasi bentuk aljabar di kelas VII SMP. Tujuan penelitian ini adalah meningkatkan hasil belajar siswa dengan menggunakan model pembelajaran kooperatif tipe Numbered Head Together (NHT) pada materi operasi bentuk aljabar di kelas VII SMP. Jenis penelitian yang digunakan adalah penelitian tindakan kelas (classroom action research) dengan teknik pengumpulan data melalui lembar observasi dan tes akhir siklus. Subjek dalam penelitian, yaitu 20 orang siswa. Hasil penelitian menujukan bahwa dengan menggunakan model pembelajaran kooperatif tipe Numbered Head Together (NHT) terdapat peningkatan hasil belajar dimana hasil tes siklus I yang mencapai kriteria ketuntasan minimal (KKM) lebih dari atau sama dengan 60 (≥60) adalah 6 orang siswa dengan persentase 30%. Pada siklus II yang mencapai kriteria ketuntasan minimal (KKM) lebih dari atau sama dengan 60 (≥60) adalah 13 orang siswa dengan persentase 65%. Dengan demikian dapat disimpulkan bahwa model pembelajaran kooperatif tipe Numbered Head Together (NHT) dapat meningkatkan hasil belajar siswa kelas VII SMP pada materi operasi bentuk aljabar.
РАЦІОНАЛЬНЕ ВИКОРИСТАННЯ ВІДХОДІВ ПИВОВАРНОГО ВИРОБНИЦТВА В ХАРЧОВІЙ ПРОМИСЛОВОСТІ
Authors: Чепурна О. Л. , Штонда О. А. 
Published: January 2025

Предмет. Обґрунтування можливості та доцільності застосування побічних продуктів пивоваріння у технології харчових продуктів. Використання відходів пивоварного виробництва в якості вторинної сировини в рецептурі харчових продуктів, зменшує обсяг утворення відходів, знижує собівартість продукції, а також вирішує питання щодо їх раціональної утилізації та вирішення проблеми забруднення навколишнього середовища. Також дає можливість отримати нові продукти з високою харчовою цінністю та біологічною активністю. Мета. Дослідити та обґрунтувати раціональне використання відходів пивоварного виробництва в харчовій промисловості як альтернативне джерело білку. Методи. Дослідження проводилося шляхом ретельного порівняльного аналізу робіт українських та зарубіжних дослідників, опублікованих у виданнях, що індексуються наукометричними базами Scopus, Web of Science, Journal Citation Reports, Scimago Journal & Country Rank, Google Scholar. Результати. Розглянуто питання щодо використання в харчовій промисловості відходів пивоварної промисловості – пивної дробини, білкового відстою та надлишкових дріжджів, які є високобілковими продуктами. Визначено можливість використання пивної дробини в хлібопекарській промисловості при виробництві хліба, печива, в м’ясній галузі в рецептурах копчених ковбас та сосисок. Щодо білкового відстою з’ясовано, що він містить такі важливі речовини, як білки та вуглеводи; однак його застосуванню перешкоджає хмельовий гіркий смак. Для зниження гіркоти в літературі запропоновано проводити водну екстракцію при високій температурі, що в подальшому дозволяє використовувати білковий відстій в харчовій промисловості. Розглянуто питання використання надлишкових пивних дріжджів в харчовій промисловості. Дріжджі являють собою густу масу з характерним дріжджовим запахом до складу яких входять білки, вуглеводи, жири і вітаміни. Відомі технології використання надлишкових дріжджів, після ретельного відмивання в пресованому вигляд, для виготовлення кондитерських та хлібних виробів. Сфера застосування результатів. Отриманні результати аналітичного огляду можуть бути використані у подальших наукових дослідженнях, щодо вдосконалення технології переробки відходів пивоварного виробництва.
ПРИНЦИПИ ЗАБЕЗПЕЧЕННЯ ОСОБИСТІСНО-ПРОФЕСІЙНОГО САМОВИЗНАЧЕННЯ МАЙБУТНІХ УЧИТЕЛІВ У ПРОЦЕСІ ВИВЧЕННЯ ПЕДАГОГІЧНИХ ДИСЦИПЛІН
Authors: Галузяк Василь 
Published: January 2025

Personal and professional self-determination of future teachers is considered as the key mechanism for formation of professional position, which is based on the processes of meaning-making, value self-determination and the formation of professional identity. The professional position as the result of personal and professional self-determination of students reflects the relatively stable system of consciously developed attitudes to various aspects of future professional activity: its subjects, goals, values, principles, technologies, methods and means of organization. The professional position characterizes the teacher as the subject of pedagogical activity, who basing on critically considered norms of pedagogical culture, has developed his own system of professional values ​​and ways of their realization. Basing on the analysis of scientific sources and pedagogical practice there was defined and substantiated the set of principles that ensures personal and professional self-determination of future teachers in the process of study of pedagogical disciplines: the principle of value-semantic contextual content of educational dialogue, the principle of coordination in dialogue of professional and personal values, the principle of transparency and self-determination, the principle of unity of normativeness and alternativeness, the principle of unity of trust and doubt, the principle of subject-subject interaction, the principle of interactivity and positional openness in dialogue, the principle of reflexivity of subjects of educational dialogue, the principle of creativity of joint activity of subjects of the dialogue. Adherence to these principles activates the personal and professional self-determination of future teachers, contributes to the formation of their professional position as the system of value orientations that form the conceptual basis of future professional activity. Effective implementation of the considered principles is possible under the condition of the use of pedagogical technologies constructed on a subject-subject basis. One of such technologies is the educational dialogue which involves the organization of intersubjective interaction during classes aimed at solving of educational problems and students' search for personal meaning in professional knowledge.
Role of Collaborative Governance towards Crisis Management: A Case Study of Provincial Disaster Management Authority (PDMA)
Authors: Shahid Zahra , Hanif Ayesha , Naqvi Syeda Hania Batool , Hassan Sobia , Gull Maryam 
Published: January 2025

The current study examines how the Provincial Disaster Management Authority (PDMA) used collaborative governance to manage crises. It also aims to identify the elements of cooperative governance, fundamental tactics, and challenges encountered during crisis management. For data collection, semi-structured interviews were used. Twelve interviews with the PDMA top management were conducted and data was transcribed through thematic analysis. It has been determined that collaborative governance and fundamental and complementary conditions impact crisis management, particularly when building collaborative processes. It has also been discovered that the key prerequisites for developing the collaborative process are leadership activities and face-to-face negotiation. Contrarily, supportive settings entail an initial understanding, trust, and commitment that enhance the collaborative process without endangering crisis management. However, the research findings connect well with existing theories especially in governance frameworks on the importance of interactive dynamics. These perceptions can enlighten future study and pursue the practices in crisis management, mostly in how collaborative governance can influence to improve awareness and resilience in disaster management struggle.
STUDY OF THE STRUCTURAL RELATIONSHIP OF HALAL-FRIENDLY DESTINATION ATTRIBUTE, PERCEIVED VALUE AND DESTINATION LOYALTY: AN INTEGRATED APPROACH
Authors: Haryeni Haryeni , Yendra Nofri 
Published: January 2025

The tourism sector has an important role as a source of foreign exchange earnings and can encourage national economic growth. Therefore, special attention needs to be paid to destination loyalty, which is the intention of tourists to revisit a destination and their willingness to recommend it. The aim of this research is to determine: the influence of halal-friendly destination attributes on perceived value, the influence of perceived value on destination loyalty and (3) the influence of halal-friendly destination attributes on destination loyalty which is mediated by perceived value. The population in this study were domestic tourists who visited halal tourist destinations in Padang City. The confirmatory factor analysis was utilized to test the construct validity and reliability of the model. The number of samples for this research was 150 respondents. The data analysis technique used in testing this research hypothesis was the use of the Partial Least Square (PLS) program to assess the hypotheses developed. The research results show that the Halal-friendly Destination Attribute has a significant effect on Perceived Value, Perceived Value has a significant effect on Destination Loyalty and the Halal-friendly Destination Attribute has a significant effect on Destination Loyalty which is mediated by Perceived Value
INFLUENCEE-QUALITY SERVICE, PERCEIVED VALUE, PROMOTIONS AND PRICES ON GOFOOD CONSUMER PURCHASING DECISIONS (Case Study at Bukit Union 2 Housing Complex Bengkong Kartini Batam)
Authors: Hisyam Magneta 
Published: January 2025

This study aims to determine the effect of e-quality service, perceived value, promotion and price on purchase decisions of GoFood consumers at Perumahan Bukit Union 2 Bengkong Kartini Batam. The type of research used in this research is quantitative research. The population of this research is GoFood users at Perumuhan Bukit Union 2 Bengkong Kartini Batam. The sampling technique in this study used total sampling with the same number of samples as the population amounted to 62 respondents. The data were obtained by using interview instruments and questionnaire instruments which had been tested for validity and reliability. Data analysis using multiple regression and hypothesis testing using SPSS version 25 test tool. The results of this study concluded that partially and simultaneously e-quality service, perceived value, promotion and price have a positive and significant impact on purchasing decisions of GoFood consumers at Perumahan Bukit Union 2 Bengkong Kartini Batam.
UPAYA PENGEMBANGAN MUTU LULUSAN IAIN AMBON MELALUI PROGRAM MENGHAFAL AL-QUR’AN
Authors: Maimunah  , Manilet Saida 
Published: January 2025

Abstract: The purpose of this study was to obtain information related to efforts to improve the quality of IAIN Ambon graduates through the tahfidz Qur'an program. The approach used in this study is a phenomenological approach with an interest in uncovering social reality to its authentic area. Data collection techniques used are documentation, observation, and interviews. After collecting the data, the data is reduced according to the research focus, then presented in the form of narratives and ends with drawing conclusions. From the results of the study, it was found that efforts to develop the quality of graduates through the tahfidz program at IAIN Ambon were only prioritized for students who had not memorized the Qur'an at all. Meanwhile, for students who already have memorization provisions, there are no regulations or special forums to accommodate them. And the results of this study found that the program given to students who did not have memorized the Qur'an in terms of evaluation was inconsistent with the regulations that had been set based on the Rector's Decree number 121 of 2017. Abstrak: Tujuan penelitian ini adalah untuk memperoleh informasi terkait upaya peningkatan mutu lulusan IAIN Ambon melalui program tahfidz al-Qur’an. Pendekatan yang digunakan dalam penelitian ini adalah pendekatan fenomenologi dengan kepentingan untuk menguak realitas sosial hingga pada wilayah autentiknya. Teknik pengumpulan data yang digunakan adalah dokumentasi, observasi, dan wawancara. Setelah data terkumpul selanjutnya direduksi sesuai fokus penelitian, setelah itu disajikan dalam bentuk narasi-narasi dan diakhiri dengan penarikan kesimpulan. Penelitian menghasilkan temuan bahwa upaya pengembangan mutu lulusan melalui program tahfidz al-Qur’an di IAIN Ambon hanya diprioritaskan bagi mahasiswa yang belum memiliki hafalan al-Qur’an sama sekali. Sedangkan bagi mahasiswa yang sudah mempunyai bekal hafalan belum ada regulasi maupun wadah khusus yang mengakomodirnya. Dan hasil penelitian ini menemukan bahwa program yang diberikan untuk mahasiswa yang belum mempunyai hafalan al-Qur’an dari sisi evaluasinya tidak konsisten terhadap regulasi yang telah ditetapkan berdasarkan SK Rektor nomor 121 tahun 2017
Cell clone selection—impact of operation modes and medium exchange strategies on clone ranking
Authors: Dorn Marie , Ferng Christine , Klottrup-Rees Kerensa , Lee Kenneth , Micheletti Martina 
Published: January 2025

Bioprocessing has been transitioning from batch to continuous processes. As a result, a considerable amount of resource was dedicated to optimising strategies for continuous production. However, the focus has been on developing a suitable and scalable perfusion strategy with little attention given to the selection of optimal cell clones. Cell line development and lead clone selection are critical to bioprocess development. The screening and selection process is typically performed in stages. Microwell plates (MWP) are used to narrow down the number of clone candidates, which will undergo further selective screening in progressively larger small-scale bioreactors (12 mL–3 L) to identify the top clone for GMP production. Perfusion mode is typically applied at bench-scale for optimisation purposes, while process development and cell clone screening studies at mL-scale still commonly use fed-batch methods. The change of operation mode from bolus feeding to perfusion with a regular exchange of medium, leads to questions regarding the reliability and fit of initial clone selection. Is the early-stage clone ranking impacted by the discrepancy in the operation mode, and does this potentially result in the exclusion of cell clones suitable for perfusion processes? To address this question, we evaluated various CHO cell clones expressing two antibody products using MWP methodologies in fed-batch and semi-perfusion mode. We assessed growth, metabolic, and productivity performance, and ranked cell clones using two different strategies. The first strategy evaluated clones based on a single parameter: the cell-specific productivity (qP). The second considered a collection of multiple parameters using the metric of the Manufacturability index (MICL). Both ranking strategies showed an impact of operation mode and perfusion rate on the clone ranking. Notably, depending on the chosen operation mode, different sets of candidate clones might have been selected for further, more extensive screening. Additionally, we evaluated the reproducibility of our results demonstrating consistency in cell clone growth performance and ranking.
The critical role of MLKL in hemorrhagic stroke and the therapeutic potential of its associated protein network
Authors: Wang Yi , Xu Moran , Zuo Xiaoli , Wang Sheng , Yu Yong , Gao Zhaobing , Qie Jingbo , Jiang Ye , Huang Fang , Xia Bingqing 
Published: January 2025

IntroductionMixed Lineage Kinase Domain-Like Protein (MLKL), as the executor of necroptosis and a critical factor in the inflammation, has been shown to be associated with the progression of hemorrhagic stroke. Studies identified MLKL is a promoting factor in this process, suggesting its potential as a therapeutic target to mitigate posthemorrhagic stroke damage. However, the mechanisms by which MLKL functions in the process of intracerebral hemorrhage (ICH)-induced damage remain unclear.MethodsHere, we explored the correlation between MLKL and pathological damage in ICH patients through histopathological staining and RT-qPCR. Furthermore, we established an intracerebral hemorrhage model by collagenase IV injection in WT and Mlkl-/- mice. Subsequently, we investigated the impact of MLKL knockout on ICH pathological damage through behavioral tests, Western blotting, and RT-qPCR. Finally, we performed a proteomic analysis via LC-MS/MS to explore the potential interacting proteins of MLKL in the progression of ICH.ResultsWe found that MLKL is highly expressed in the brain tissue of ICH patients and is positively correlated with the extent of injury. However, we found that Mlkl knockout alone was insufficient to fully reverse neuroinflammation and pathological damage. Although Mlkl knockout has a limited effect on alleviating ICH damage, proteomics results indicate that MLKL can mitigate changes in proteins associated with inflammation, metabolism, and coagulation pathways, suggesting that MLKL may exert its effects through these pathways.DiscussionIn summary, our results suggest that although MLKL is associated with the progression of ICH, single knockout of Mlkl is insufficient to fully reverse the pathological damage of ICH. Proteomic analysis indicates that co-targeting MLKL and its associated protein network may yield better therapeutic outcomes for hemorrhagic stroke.
Molecular mechanisms of renal cell carcinoma metastasis and potential targets for therapy
Authors: Li Xinwei , Xiong Wei , Xiong Zhiyong , Zhang Xiaoping 
Published: January 2025

Renal cell carcinoma is a common type of cancer, with approximately 30% of patients potentially developing metastatic disease. Some patients with metastatic renal cell carcinoma are found in advanced stages, so the 5-year survival rate for metastatic renal cell carcinoma is only 14%. Currently, there are several drugs available for patients with metastatic renal cell carcinoma, and their overall survival can be extended to nearly 5 years. However, the sensitivity and efficacy of the treatment are still unsatisfactory. New targets and drugs to improve patient prognosis are urgently needed, but these are closely linked to the molecular mechanisms of renal cell carcinoma metastasis. In this review, we present the definition and common molecular mechanisms of metastatic renal cell carcinoma and provide new insights on their potential link to targeted therapies, which may enlighten scientists to develop future targeted therapeutic agents to improve the prognosis of patients with metastatic renal cell carcinoma.
Identification of serotype O3b and high-risk clone ST37 of Klebsiella pneumoniae revealed by comparative genomic analysis
Authors: Krishnan Sivaraman Gopalan , Sajeev Sudha , Sivam Visnuvinayagam , T. Raja Swaminathan , Ojha Rakshit , Shome Bibek Ranjan , Holmes Mark , Sundaram Thanigaivel , M. D. Ramesh , Vinayagam Saranya , Meesala Suseela , Malik Tabarak , Dara Pavan Kumar 
Published: January 2025

BackgroundEpidemiological risk factors such as the demography of a place, environment, food, livestock, and companion animals are known sources of Klebsiella pneumoniae infection. Whole-genome sequencing (WGS) has become a powerful tool to complement traditional microbiological characterization of foodborne pathogens. Moreover, K. pneumoniae has several species complexes (KpSC) and is very difficult to differentiate using routine microbiological methods. The present study aims to investigate the prevalence of K. pneumoniae in fish available in the retail market using WGS.MethodsIsolation of K. pneumoniae, identification of K. pneumoniae isolates, and determination of the minimum inhibitory concentration (MIC) were performed. Whole-genome sequencing of K. pneumoniae genomes and phylogenomic analysis were conducted for visual comparison of the genomes. Furthermore, genomes of non-human origin that were submitted from India to the NCBI database were downloaded and included in the comparative analysis.ResultsThe findings showed that many antibiotic-resistant genes (ARGs) are prominent, including acrD, BaeR, cpxA, mdtB, mdtC, CRP, H-NS, KpnE, KpnF, KpnG, KpnH, acrA, acrB, marA, ramB, oqxA, oqxB, LptD, and emrR. Four fish-sourced isolates had different blaSHV resistance gene variants. The presence of ARGs for aminoglycosides [aac(3)-IId], fluoroquinolones (oqxA, oqxB), and fosfomycin (fosA5, fosA6) in these K. pneumoniae isolates from fish sources was found. One of the CIFT-K6 isolates had the uncommon serotype of K. pneumoniae O3b with the high-risk clone “ST37.” The ST515 sequence type was present in two K. pneumoniae isolates (CIFT-K7 and CIFT-K8), but the O3b serotype and ST192 allele type were present in the CIFT-K10 isolate.ConclusionTo the best of our knowledge, this research study represents the first Indian report of K. pneumoniae linked to fish, specifically the high-risk clone ‘ST37’ and two other STs, 515 and 192. The most common plasmid type detected in all four isolates was IncFIB, and 75% of the isolates were IncFII and IncHI1B. The prevalence of ARGs linked to efflux pump resistance mechanisms is highlighted by the analysis of genome sequence data.