bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENJATUHAN PIDANA DENDA TERHADAP ANAK YANG MELAKUKAN TINDAK PIDANA PERSETUBUHAN DALAM PUTUSAN NOMOR 1/PID.SUS-ANAK/2019/PN.PTS
Authors: Prastyoso ' , Subekti ' 
Published: May 2023

<p>Abstrak<br />Penelitian hukum ini bertujuan untuk menganalisis penjatuhan pidana denda terhadap anak yang melakukan tindak pidana persetubuhan dalam Putusan Pengadilan Negeri Putussibau Nomor 1/Pid. Sus-Anak/2019/PN.PTS. Penelitian ini menggunakan metode penelitian hukum normatif dengan sifat preskriptif. Pendekatan yang digunakan ialah pendekatan perundang-undangan dan pendekatan kasus. Bahan hukum yang digunakan terdiri dari bahan hukum primer dan bahan hukum sekunder. Teknik pengumpulan bahan hukum yang digunakan ialah studi kepustakaan. Teknik analisis yang digunakan ialah teknik deduksi dengan metode silogisme hukum. Hasil penelitian menunjukkan bahwa penerapan penjatuhan denda terhadap Anak telah diatur dalam Pasal 71 Ayat 3 Undang-Undang Nomor 11 Tahun 2012 yang menyatakan bahwa penjatuhan pidana denda harus digantikan dengan pelatihan kerja bagi Anak.<br />Kata Kunci : Pidana Denda, Anak, Tindak Pidana Persetubuhan.</p><p>Abstract<br />This legal research aims to analyze the imposition of fine for a child who commits sexuality within The Verdict of Putussibau District Court Number 1/Pid.Sus-Anak/2019/PN.PTS. This research used normative legal research with prescriptive characteristic. This research used statute approach and case approach. The legal material consists of primary legal meterials and secondary legal materials, the legal sources was obtained by literature study. The legal sources was analyzed by using deductive sylogism law method. The result shows that Law Number 11 of 2012 concerning Juvenile Justice System has erased the provision on fine towards Juvenile Delinquency through the change of fine into work training form so they can’t be imposed by fine except in the form of work training. The Verdict of Putussibau District Court Number 1/Pid.Sus-Anak/2019/PN.PTS shows that is still such fine imposition towards Juvenile Delinquency which is not transferred into work training. The prosecutors and the judges in the mentioned verdict didn’t apply the provision of Article 71 paragraph 3 Law Number 11 of 2012 concerning Juvenile Justice System on indictment and conviction.<br />Keywords : Fines, Juvenile Delinquency, Sexuality</p>
The role and mechanism of calcitriol in promoting intestinal injury in AKI by improving the intestinal barrier
Authors: Huo Aijing , FengmeiWang  , Xia Jingjing , Wang Haoyu 
Published: May 2023

Abstract
Background：The intestinal microbiota affects the inflammatory status of the host and the prognosis of diseases. AKI can lead to microinflammation of intestinal tract and changes of intestinal flora. Calcitriol (Cal) has a protective effect on the intestine.
Methods and Results：In the AKI rat model, intestinal infiltration of inflammatory cells and the deterioration of renal function were significantly alleviated by Cal pretreatment. By increasing the levels of Zonula Occludens-1(ZO-1 and Occludin), Cal significantly prevented the destruction of the intestinal barrier in AKI. In AKI rats, Cal decreased the concentration of Proteobacteria and enhanced the linear discriminant (LDA) score of beneficial bacteria (such as Lactobacillus). Cal increased the expression of butyric acid among intestinal metabolites. Cal supplementation decreased serum LPS levels and downstream HMGB1-MYD88-NF-κB-p65 signaling.
Conclusions：High-dose Cal may play a protective role in AKI by regulating HMGB1-MYD88-NF-κB-p65 signaling pathways and the intestinal microbiota in rats. This study demonstrates the renal effects of Cal. The experiment revealed a close interaction between the kidney and the intestine. It provides new insights for the treatment of AKI.
Association Between the Oxidative Stress Gene Polymorphism and Chronic Obstructive Pulmonary Disease Risk: A Meta-Analysis
Authors: Zhou Ting , Zuo Qiunan , Chen Mengchun , Zhao Yingying , Li Xiaohui , Guo Shujin 
Published: May 2023

Abstract
Background The association between the oxidative stress gene polymorphism and chronic obstructive pulmonary disease (COPD) risk has been extensively studied but the results have been controversial. This study aimed to investigate the overall association between the oxidative stress gene polymorphism and the risk of COPD.Methods We searched the PubMed and EMBASE database to identify studies that investigated the association between the oxidative stress gene polymorphism and risk of COPD. The relevant data were extracted and statistical analyses were performed using the Revman 5.4 and STATA 12 software. Dominant genetic model, recessive model, co-dominant model, heterozygote model, and allele model were analyzed. Venice criteria and publication bias were conducted to access the credibility and reliability.Results A total of 63 publications were included in the meta-analysis.15 genetic variants of 6 genes were analyzed, and seven SNP in GSTP1, CAT, CYP, SOD were first analyses until now. In our study, EPHX T113C C allele, GSTM1 null, GSTT1 null, GSTP1 A313G G and C341T T allele, CYP1A1 MspI C allele, SOD3 A213G G allele and L type in Ho-1 showed increased COPD risk, especially in Asians. T allele in CAT C262T and C allele in SOD2 Val 9 Ala were associated with decreased COPD risk. Subgroups analysis were performed in accord with HWE and ethnicity. Publication bias was assessed by Begg’s funnel plots and Egger’s test, and no publication bias were found for recessive models. 4 variants were identified with strong levels of epidemiological evidence of associations with the COPD risk.Conclusions Our results confirm that oxidative stress gene polymorphism was associated with COPD risk. Well-designed studies with large sample sizes are essential to clarify the association of these significant variants with the susceptibility to COPD.
How are protective behaviors against COVID-19 socially controlled?
Authors: Mejia Cristian Yesid Urbano , Gallardo Juan Pablo Molano , Villalba Julián Zanguña , Clavijo Arturo 
Published: May 2023

Abstract
During the COVID-19 pandemic, individuals adjusted their adherence to protective behaviors according to the social situation. Also, social consequences partially influenced, given that they were the most contiguous and likely to adherence behavior. The behavior analysis framework can help to understand the social contingencies that maintain adherence on a large scale in natural settings. This study assessed how social antecedents and consequences influenced adherence to protective behaviors. The antecedents were indoor and outdoor. The social consequences were receiving social approval, avoiding social disapproval, receiving a social rejection, and losing gratification in social relationships. The protective behaviors were mask-wearing, physical distancing, hand-washing, and correcting others. Colombian residents completed an online survey based on the indirect functional assessment in which they reported their adherence to the social contexts and the perceived social contingencies. People reported higher adherence to protective behaviors in the outdoor context than indoors. Social approval was the main reinforcer, and losing gratification in social relationships was the main punisher. Also, avoiding being judged worked as a reinforcer, and receiving social rejection worked as a punisher. Social context interacted with social consequences. The effect of consequences under adherence behavior was more intense in indoor than outdoor contexts. Mask-wearing and physical distancing were the more socially controlled protective behaviors. We demonstrated that the probability of certain social consequences partially explained adherence's subjective value. Our results about social approval were consistent with injunctive norm literature. Social distance with people involved in each social context can explain our findings.
Design and Analysis of Nonlinear Numerical Algorithm for Seismic Response of Structures Based on HVSR Algorithm
Authors: Wang Shuai , Wang Chao , Zhang Zongbao 
Published: May 2023

Abstract
Earthquakes are one of the main factors that cause structural disasters in current buildings. Under the action of earthquakes, adjacent building structures are generally in different vibration phases, and the structures are likely to collide with each other, and collisions may cause serious damage to the structure. In order to prevent damage to the designed buildings under certain earthquakes, this paper mainly focuses on the design and analysis of numerical algorithms for seismic nonlinear structural dynamic responses based on the HVSR algorithm. In the two-dimensional finite element analysis in this paper, the dam rockfill body adopts four-node isoparametric elements, and the equivalent linear model related to dynamic shear strain is used to reflect the dynamic nonlinear characteristics of the dam material. When the dynamic response is used as the constraint condition, the dynamic response can be used to judge whether the design variables meet the requirements; when the dynamic response is used as the optimization target, it is the optimization result of each step. Considering the importance of the instantaneous amplitude of acceleration response in the correction of nonlinear structure model. The acceleration response time series is divided into 15 time periods uniformly, and then the position corresponding to the peak point of the instantaneous amplitude in each time period is selected as the selected data point position. Apply the same seismic load to the bottom of the established nonlinear model, extract the dynamic response data of the top layer of the structure, and then extract the instantaneous amplitude of the main component of the structural dynamic response through the time-varying filter and Hilbert transform based on discrete analytical mode decomposition and the corresponding the instantaneous frequency. Under the action of these four ground motions, the collision force in the range of 0~50kN accounts for more than 87% of the total number of collisions. The results show that the HVSR algorithm can obtain the instantaneous characteristic parameters of the dynamic response of the nonlinear structure and realize the correction of the model.
2-year survival and cost analysis of occlusoproximal ART restorations using encapsulated glass ionomer cement in primary molars: a randomized clinical trial
Authors: Garbim Jonathan Rafael , Saihara Cintia Saori , Olegário Isabel Cristina , Hesse Daniela , de Araujo Mariana Pinheiro , Bonifácio Clarissa Calil , Braga Mariana Minatel , Raggio Daniela Prócida 
Published: May 2023

Abstract
Background
Encapsulated glass ionomer cement is a promising option for atraumatic restorative treatment due to its potential to minimize the operator factor. This study aimed to compare two encapsulated glass ionomer cements, Equia Forte (GC Corp) and Riva Self Cure (SDI), in terms of their survival rates and costs for restoring occluso-proximal cavities in primary molars. The study was conducted in the city of Tietê, Brazil, and followed up with children over a period of 24 months.
Methods
Children aged 4–8 years with occlusal-proximal dentin carious lesions in primary molars were randomly assigned to receive either Equia Forte (EF) or Riva Self Cure (RSC). The primary outcome was 24-month restoration survival, analyzed using Kaplan-Meier survival analysis, Cox regression, and intention-to-treat (ITT) analysis. Secondary outcomes included a 24-month restoration cost analysis using Monte-Carlo simulation. Treatment was performed by two trained final-year students in a school setting, and one trained and calibrated examiner evaluated the restorations after 2, 6, 12, 18, and 24 months.
Results
A total of 152 children (76 in EF group and 76 in RSC group) were included in the study, and 135 (88.8%) were followed up at 24 months. There was no significant difference in the primary outcome between the two groups, with an overall restoration survival rate of 39% (45% in EF and 32% in RSC). However, there was a significant difference in the estimated incremental cost between the two groups, with RSC being more cost-effective from the Brazilian perspective (EF cost: $25.48, RSC cost: $19.30, incremental cost: US$6.18).
Conclusion
After two years of follow-up, Riva Self Cure showed comparable restoration survival to Equia Forte, while being more cost-effective from the Brazilian perspective. Encapsulated glass ionomer cements are a viable option for atraumatic restorative treatment, and their cost-effectiveness should be considered when selecting a material for such treatments.
Trial Registration
This randomized clinical trial was registered on ClinicalTrials.Gov - NCT02730000 (06/04/2016)
The role of genetic factors in different outcomes of pediatric myelodysplastic syndromes
Authors: Li Ying , Cheng Li , Peng Yun , Wang Lin , Zhang Wenzhi , Yin Yuhong , Zhang Jing , Wu Xiaoyan 
Published: May 2023

Abstract
Background
To explore the role of genetic factors in the pathogenesis of myelodysplastic syndrome (MDS) in children with different outcomes and to discover the correlation between genetic features and clinical outcomes as well as disease characteristics.
Methods
We analyzed the archived genetic data from 26 patients who were diagnosed of pediatric MDS at our institution between 2015 and 2021, and evaluated the association between different genetic characteristics and clinical manifestations as well as prognosis. We also took 3 patients with different genetic background and outcomes as examples to elaborate the role of genetic factors in different prognoses.
Results
Genetic variations were found in 13 (8 RCC, 4 MDS-EB, 1 MDS-EB-t, the latter two types are classified as advanced MDS) of the 26 patients. In RCC group, transfusion dependency (2/4 vs. 1/4) and disease progression (2/4 vs. 1/4) occurred more frequently in patients with co-occurrence of somatic and germline mutations (CSGMs) than those with somatic mutations alone. CSGMs (4/5 in advanced MDS, 4/8 in RCC), germline pathogenic variants (2/4 in advanced MDS, 1/4 in RCC) and somatic mutations specifically associated with MDS (6/6 in advanced MDS, 8/15 in RCC) were also identified in our study. Three patients with distinct genetic variations taken as examples in our study presented evidently different clinical outcomes. Case 1 with germline and somatic mutations of unknown significance had a relatively slow disease course and a good prognosis. Case 2 with compound heterozygous germline SBDS variants and somatic mutations such as del20q had a reversed disease outcome and a stable clinical course. Case 3 with a germline GATA2 variant and somatic mutations including − 7 had a rapidly progressive course of disease and a worst prognosis.
Conclusion
Our findings indicate that genetic background of pediatric MDS is closely linked with disease characteristic as well as outcome and that CSGMs leads to disease progression and poor clinical manifestations. It should be emphasized that the interaction between certain germline variants and somatic mutations, such as SBDS and del20q, may result in hematopoietic stem cell adaptation (improve hematopoiesis) and reverse adverse clinical outcomes, which can facilitate the development of targeted therapy.
Screening of the antileishmanial and antiplasmodial potential of synthetic 2-arylquinoline analogs
Authors: Espinosa-Saez Roger , Robledo Sara M. , Pineda Tatiana , Murillo Javier , Zúñiga César , Yañez Osvaldo , Cantero-López Plinio , Saez-Vega Alex , Guzmán-Teran Camilo 
Published: May 2023

Abstract

In this study, six analogs of 2-arylquinoline were synthesized and evaluated for their in vitro and in vivo antiplasmodial and leishamanicidal activity. Also, hemolytic activity and drugability were tested in vitro and in silico, respectively. In relationship to leishmanicidal activity, the compounds showed half maximal effective concentration (EC50) values between 3.6µM and 19.3µM. Likewise, treatment using compounds 4a-f caused improvement in most of treated hamsters and cured some of them. Regarding antiplasmodial activity, the compounds showed moderate to high activity, did not show hemolytic activity. Furthermore, 4e and 4f compounds were not able to control P. berghei infection when administered to animal models. Molecular dynamic simulations, molecular docking and ligand binding affinity indicate good bioavailability and absorption characteristics of the studied compounds, which are expected to be active when administered orally. The compounds are absorbable at the hematoencephalic barrier but not in the gastrointestinal tract. ADMET properties suggest that these molecules may be used as a safe treatment for Leishmania.
Large-scale networks changes in Wilson's disease associated with neuropsychiatric impairments: a resting-state functional magnetic resonance imaging study
Authors: Wang Anqin , Dong Ting , Wei Taohua , Wu Hongli , Yang Yulong , Ding Yufeng , Li Chuanfu , Yang Wenming 
Published: May 2023

Abstract
Background In Wilson’s disease (WD) patients, network connections across the brain are disrupted, affecting multidomain function. While the details of this neuropathophysiological mechanism remain unclear due to the rarity of WD. In this study, we aimed to investigate alterations in brain network connectivity at the whole-brain level (both intra- and inter-network) in WD patients through independent component analysis (ICA) and the relationship between alterations in these brain network functional connections (FCs) and clinical neuropsychiatric features to understand the underlying pathophysiological and central compensatory mechanisms.Methods 85 patients with WD and age- and sex-matched 85 healthy control (HC) were recruited for resting-state functional magnetic resonance imaging (rs-fMRI) scanning. We extracted the resting-state networks (RSNs) using the ICA method, analyzed the changes of FC in these networks and the correlation between alterations in FCs and clinical neuropsychiatric features.Results Compared with HC, WD showed widespread lower connectivity within RSNs, involving default mode network (DMN), frontoparietal network (FPN), somatomotor network (SMN), dorsal attention network (DAN). Furthermore, the decreased FCs in the left medial prefrontal cortex (L_ MPFC), left anterior cingulate gyrus (L_ACC), precuneus (PCUN)within DMN were negatively correlated with the Unified Wilson’s Disease Rating Scale-neurological characteristic examination (UWDRS-N), and the decreased FCs in the L_MPFC, PCUN within DMN were negatively correlated with the Unified Wilson’s Disease Rating Scale-psychiatric symptoms examination (UWDRS-P). We additionally discovered that the patients with WD exhibited significantly stronger FC between the FPN and DMN, between the DAN and DMN, and between the FPN and DAN compared to HC.Conclusions we have provided evidence that WD is a disease with widespread dysfunctional connectivity in resting networks in brain, leading to neurological features and psychiatric symptoms (e.g. higher-order cognitive control and motor control impairments). The altered intra- and inter-network in the brain may be the neural underpinnings for the neuropathological symptoms and the process of injury compensation in WD patients.
MicroRNA146a-loaded Magnesium Silicate Nanospheres promote bone regeneration with inflammatory microenvironment
Authors: Chen Qianming , Yang Jiakang , Jing Shuai , Siow Lixuen , Lu Jingyi , Sun Miao , An Wenyue , Yu Mengfei , Wang Baixiang 
Published: May 2023

Abstract
The reconstruction of irregular oral-maxillofacial bone defects with an inflammatory microenvironment remains a clinical challenge as chronic local inflammation can largely impair bone healing. Here, we used magnesium silicate nanospheres (MSN) to load a nucleic acid drug - microRNA146a-5p (miR146a), fabricating a nanobiomaterial complex MSN-miR146a with high oligo transfection efficiency. This complex showed a potent promoting effect on osteogenic differentiation of human dental pulp stem cells with upregulated expression of osteogenesis markers including alkaline phosphatase, collagen Ⅰ, Runt-related transcription factor 2, osteopontin and Osterix. Additionally, miR146a was observed to have an anti-inflammatory effect by reducing CD40high M1 pro-inflammatory mouse bone marrow derived macrophages under lipopolysaccharide stimulation, with MSN simultaneously upregulating Arginase-1high or CD163high M2 pro-regenerative BMMs. The osteogenic-promoting and immunoregulatory effects of MSN-miR146a were further validated in a mouse-infected mandibular bone defect model delivered by photocuring hydrogel. Collectively, the MSN-miR146a complex revealed great potential in treating inflammatory irregular oral-maxillofacial bone defects.
Nanoparticles with adaptable self-assembled shells sense and inhibit influenza virus at ultra-low concentrations
Authors: Sergeeva Yulia , Yeung Sing Yee , Hix-Janssens Thomas , Sellergren Börje 
Published: May 2023

Abstract
Multivalent inhibitors that mimic the polysaccharide array on cells represent a new paradigm in the development of antiviral agents and antibiotics. Covalent ligand anchoring limits the affinity and in turn potency of these inhibitors with dissociation constants (Kd) commonly found in the micromolar or upper nanomolar range. Addressing this deficiency we here report on easily accessible gold core-shell nanoparticles (rSAM-NPs) featuring adaptable reversible self-assembled monolayer (rSAM) -based shells. The rSAMs are anchored by non-covalent amidinium-carboxylate interaction on gold nanoparticles at slightly alkaline pH resulting in laterally mobile pH-responsive assemblies that are functional at physiological pH. Introducing sialic acid ligands in the shell, we show that the rSAM-NPs strongly interact with the influenza virus surface protein hemagglutinin (limit of detection LoD < 2 nM) and deactivated bird flue virus (LoD < 1 HAU) in allantoic liquid. Finally, we show that the rSAM-NPs effectively inhibit the interaction of the virus with red blood cells at concentrations in the low picomolar range. This represents a more than 1000-fold increased potency with respect to monosaccharide-based multivalent inhibitors.
Delineating Sub-basins of Sedimentary Rock Structure beneath Eastern Central Sumatra Basin Using Integrated Gravity, Seismic and Well Data Analysis
Authors: Nainggolan Tumpal Bernhard , Kusnida Dida , Mirnanda Eddy , Setiadi Imam , Nugroho Erwin Hariyanto , Subagio Subagio 
Published: May 2023

Abstract
The Central Sumatra Basin is a vast sedimentary basin and has been proven to produce hydrocarbon; this basin consists of several different sub-basins that cannot be well-imaged with conventional seismic reflection section and limited well log data. This research aims to delineate sedimentary sub-basins, interpret the sub-surface geological model and identify geological structures beneath Eastern Central Sumatra Basin using integrated geophysical gravity, seismic and well data analysis. The sub-basins that can be delineated from the gravity data analysis are 13 sedimentary sub-basins, while the structural patterns identified are basement height, graben and fault. The 3D modeling results indicate that the Pre-Tertiary granitic basement is a continental crust with a mass density value of 2.67 gr/cc. Sedimentary rock from modeling results from the bottom to up, which is Early Oligocene-Middle Miocene sedimentary rock with a mass density value of 2.35 gr/cc. The results of the sub-surface geological modeling analysis show, based on the graben pattern and the basement high beneath the Eastern Central Sumatra Basin, many structural patterns support the development of petroleum systems similar to the western part of the basin that has already produced hydrocarbon. Our study also revealed the thickness of the Sihapas Formation, which is believed to have hydrocarbon reservoir potential.