bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unveiling the Intercompartmental Signaling Axis: Mitochondrial to ER Stress Response (MERSR) and its Impact on Proteostasis
Authors: Li Jeson J , Xin Nan , Yang Chunxia , Tavizon Larissa A , Hong Ruth , Park Jina , Moore Travis I , Tharyan Rebecca George , Antebi Adam , Kim Hyun-Eui 
Published: September 2023

AbstractMaintaining protein homeostasis is essential for cellular health. Our previous research uncovered a cross-compartmental Mitochondrial to Cytosolic Stress Response, activated by the perturbation of mitochondrial proteostasis, which ultimately results in the improvement of proteostasis in the cytosol. Here, we found that this signaling axis also influences the unfolded protein response of the endoplasmic reticulum (UPRER), suggesting the presence of a Mitochondria to ER Stress Response (MERSR). During MERSR, the IRE1 branch of UPRERis inhibited, introducing a previously unknown regulatory component of MCSR. Moreover, proteostasis is enhanced through the upregulation of the PERK-eIF2α signaling pathway, increasing phosphorylation of eIF2α and improving the ER’s ability to handle proteostasis. MERSR activation in both polyglutamine and amyloid-beta peptide-expressingC. elegansdisease models also led to improvement in both aggregate burden and overall disease outcome. These findings shed light on the coordination between the mitochondria and the ER in maintaining cellular proteostasis and provide further evidence for the importance of intercompartmental signaling.
Organ-specific prioritization and annotation of non-coding regulatory variants in the human genome
Authors: Zhao Nanxiang , Dong Shengcheng , Boyle Alan P 
Published: September 2023

AbstractIdentifying non-coding regulatory variants in the human genome remains a challenging task in genomics. Recently we advanced our leading regulatory variant database, RegulomeDB, to its second version. Building upon this comprehensive database, we developed a novel machine-learning architecture with stacked generalization, TLand, which utilizes RegulomeDB-derived features to predict regulatory variants at cell or organ-specific levels. In our holdout benchmarking, TLand consistently outperformed state-of-the-art models, demonstrating its ability to generalize to new cell lines or organs. We trained three types of organ-specific TLand models to overcome the common model bias toward high data availability cell lines or organs. These models accurately prioritize relevant organs for 2 million GWAS SNPs associated with GWAS traits. Moreover, our analysis of top-scoring variants in specific organ models showed a high enrichment of relevant GWAS traits. We expect that TLand and RegulomeDB will further advance our ability to understand human regulatory variants genome-wide.
Disease prevalence, health-related and socio-demographic factors in the GCAT cohort. A comparison with the general population of Catalonia
Authors: Blay Natalia , Carrasco-Ribelles Lucía A , Farré Xavier , Iraola-Guzmán Susana , Danés-Castells Marc , Violán Concepción , de Cid Rafael 
Published: September 2023

AbstractBackgroundPopulation-based cohorts play a key role in epidemiological studies. However, it is known that volunteer cohorts include a healthy volunteer bias. Assessment and characterization of this bias is needed to extrapolate results to the general population. Here, we assess the bias of the population-based cohort GCAT, encompassing 20 000 adult participants from Catalonia with electronic health record data. The aim of this study is to compare the GCAT cohort with its age-matching Catalan population, to assess their representativeness, as well as determining the weights to make results generalisable.MethodsStatistical comparisons until 2019 in multiple variables across sociodemographic, lifestyle, diseases and medication domains were performed by stratified analysis with Fisher’s exact test and t-test. Electronic health records of Catalonia (SIDIAP), and registers from the statistics institute of Catalonia (IDESCAT) and Spain (INE) were used to make the comparisons. We generated weights accounting for sociodemographic, lifestyle and multimorbidity factors.ResultsGCAT cohort is enriched in women and younger individuals, with higher socioeconomic status, more health conscious and healthier in terms of mortality and chronic disease prevalence. We have shown that this bias can be corrected with weighting techniques, providing a more representative sample of the general population.ConclusionsThe application of multidomain weights, encompassing not only sociodemographic aspects, but also lifestyle and health-related variables, has effectively diminished the observed bias in disease prevalence estimates within the GCAT cohort. This correction has led to an enhancement of the cohort’s representativeness, rendering it more akin to the general population of Catalonia.
Chronic deregulation of the spindle assembly checkpoint triggers myelosuppression and gastrointestinal atrophy
Authors: Karbon Gerlinde , Schuler Fabian , Haschka Manuel , Drach Mathias , Sotillo Rocio , Geley Stephan , Spierings Diana C.M. , Tijhuis Andrea E. , Foijer Floris , Villunger Andreas 
Published: September 2023

ABSTRACTInterference with microtubule dynamics in mitosis activates the spindle assembly checkpoint (SAC) to prevent chromosome segregation errors. The SAC induces mitotic arrest by inhibiting the anaphase-promoting complex (APC) via the mitotic checkpoint complex (MCC). The MCC component MAD2 neutralises the critical APC cofactor, CDC20, preventing mitotic exit. In cancer cell lines, this can provoke apoptosis involving pro-apoptotic BCL2 family members BIM and NOXA while BCL2 overexpression blocks mitotic cell death, facilitating SAC adaptation. However, the consequences of apoptosis after SAC perturbation in vivo are unclear. By conditional MAD2 overexpression across tissues in mice, we observed that chronic SAC activation triggers bone marrow aplasia and intestinal atrophy. While myelosuppression was tolerated, gastrointestinal atrophy was detrimental. Remarkably, co-deletion of Bim/Bcl2l11, but not Bid, Puma/Bbc3 or Noxa/Pmaip, prevented developing gastrointestinal syndrome caused by chronic SAC activity, identifying BIM as rate-limiting for mitotic cell death in the gastrointestinal epithelium. In contrast, only BCL2 overexpression but none of the BH3-only protein deficiencies tested could mitigate myelosuppression, highlighting tissue and cell type-specific survival dependencies in response to SAC perturbation in vivo.
Information on the processing of organic food: consumers' perception
Authors: Sinesio Fiorella , Saba Anna , Moneta Elisabetta , Peparaio Marina , Saggia Civitelli Eleonora , Paoletti Flavio 
Published: September 2023

PurposeThe study aimed to investigate consumers’ views on criteria to be claimed for organic processed foods and information to be communicated.Design/methodology/approachAn online survey was carried out among 439 adults living in Italy, users of processed organic food, to gather opinions on criteria that processing of organic food should meet and on the terms that best define “careful” processing. Next, a conjoint design was applied to examine the effects of five independent factors on consumers' ideal concept of “organic”; these were potential information on packaging, processing, additives and product quality, and the type of food product. Three products with different processing level were selected: an ultra-processed and multi-ingredient product (vegetable burger), a processed product preserved by canning (peas in glass jar) and a minimally processed product (bagged salad).FindingsThe findings highlight that consumers attach more importance to the organic food carrier than the informational messages. Information on the processing and packaging follows, with messages on quality and on additives seemingly of minor importance. Three clusters of respondents were identified: those driven primarily by the type of organic food (24.6%), those placing more emphasis on product processing (21.3%), and a third larger cluster (54.1%) who expressed almost equal importance to all the factors considered. As for the processing of organic products, “eco-friendly” was the best message.Originality/valueThis paper offers insights into what best outlines the ideal concept of “processed organic food” as seen by organic food consumers, to be communicated to better guide their purchasing decisions.
Multidimensional knowledge discovery of cultural relics resources in the Tang tomb mural category
Authors: Gao Ying , Zhang Qiang , Wang Xiaoran , Huang Yanmei , Meng Fanshuang , Tao Wan 
Published: September 2023

Purpose
Currently, the Tang tomb mural cultural relic resources are presented in a multi-source and heterogeneous manner, with a lack of effective organization and sharing between resources. Therefore, this study aims to propose a multidimensional knowledge discovery solution for Tang tomb mural cultural relic resources.

Design/methodology/approach
Taking the Tang tomb murals collected by the Shaanxi History Museum as an example, based on clarifying the relevant concepts of Tang tomb mural resources and considering both dynamic and static dimensions, a top-down approach was adopted to first construct an ontology model of Tang tomb mural type cultural relics resources. Then, the actual case data was imported into the Neo4J graph database according to the defined pattern hierarchy to complete the static organization of knowledge, and presented in a multimodal form in knowledge reasoning and retrieval. In addition, geographic information system (GIS) technology is used to dynamically display the spatiotemporal distribution of Tang tomb mural resources, and the distribution trend is analysed from a digital humanistic perspective.

Findings
The multi-dimensional knowledge discovery of Tang tomb mural cultural relics resources can help establish the correlation and spatiotemporal relationship between resources, providing support for semantic retrieval and navigation, knowledge discovery and visualization and so on.

Originality/value
This study takes the murals in the collection of the Shaanxi History Museum as an example, revealing potential knowledge associations in a static and intelligent way, achieving knowledge discovery and management of Tang tomb murals, and dynamically presents the spatial distribution of Tang tomb murals through GIS technology, meeting the knowledge presentation needs of different users and opening up new ideas for the study of Tang tomb murals.
Money laundering: effectiveness of the corporate social responsibility (CSR) law in the UAE
Authors: Al-Tawil Tareq Na′el 
Published: September 2023

Purpose
The purpose of this paper is to examine the extent to which the corporate social responsibility (CSR) law will help combat money laundering in the United Arab Emirates (UAE).

Design/methodology/approach
The paper will first focus on examining whether money laundering and CSR are compatible. Such an analysis will then inform decisions on whether to include anti-money laundering in CSR disclosure requirements.

Findings
Key findings from the analysis have shown that the UAE CSR law does not explicitly mention money laundering as part of CSR disclosure requirements. Anti-money laundering (AML) and CSR are compatible and convergence, but money laundering is not yet an integral element of CSR disclosure requirements.

Originality/value
There are no clear mechanisms or provisions under the UAE CSR law on how money laundering can be included in CSR disclosure requirements, whether voluntary or mandatory. A pressing challenge now is whether the UAE should regulate AML/combatting the financing of terrorism disclosures under the CSR law. The main concern is that such a move could make mandatory disclosure another technical and regulatory requirement that UAE business must comply, which will be inimical to fostering a strong CSR culture.
Expanding financial inclusion in Indonesia through Takaful: opportunities, challenges and sustainability
Authors: Alhammadi Salah 
Published: September 2023

Purpose
This study aims to investigate the relationship between financial inclusion and sustainable economic development in Indonesia by exploring the potential impact of Takaful. Specifically, the study seeks to examine the feasibility of leveraging Takaful as a means to foster financial inclusion and drive economic growth in Indonesia.

Design/methodology/approach
This study uses a qualitative analysis methodology, specifically using content analysis techniques, to investigate the relationship between financial inclusion and sustainable economic growth in Indonesia, focussing on the role of Takaful. The content analysis enables a systematic study of the data to identify trends and topics pertinent to Takaful and its potential to advance financial inclusion.

Findings
The study’s results reveal a direct causal link between economic growth and achieving financial inclusion through the use of Takaful. The findings also indicate a positive correlation between the increased presence of Takaful markets and accelerated economic growth.

Research limitations/implications
The study examines only the use of Takaful in achieving financial inclusion and sustainable economic growth in Indonesia. Nonetheless, the practical implications of this research are substantial, as they highlight the potential of Takaful to foster financial inclusion and stimulate economic growth in Indonesia.

Practical implications
This study contributes to the limited body of research on the relationship between financial inclusion and economic growth in Indonesia, specifically in the context of Takaful.

Originality/value
This study’s value lies in its exploration of an under-researched area, providing crucial insights into the potential of Takaful to promote financial inclusion and drive economic growth in Indonesia. The social implications of this study are also noteworthy, as increased financial inclusion and economic growth can positively affect poverty reduction, job creation and overall societal well-being in Indonesia.
Trends of research on women's entrepreneurship on the management of happiness and well-being in organisations
Authors: de las Heras-Pedrosa Carlos , Jambrino-Maldonado Carmen , Rando-Cueto Dolores , Iglesias-Sánchez Patricia P. 
Published: September 2023

PurposeThe management of employee happiness and well-being has been gaining interest in academic research in recent years; however, few studies have focussed on the entrepreneur's perspective. The aim of this paper is to analyse the state of research on women-led businesses, well-being and happiness management.Design/methodology/approachA bibliometric study has been carried out since 1996, the first year in which publications in this field were detected. In total, 128 papers are identified in the most reliable database, Web of Science Core Collection. A network mapping of authorship, citation and co-occurrence of keywords in scientific publications is shown.FindingsThe results of this study confirm that societal changes resulting from crises increase research interest in improving organisational environments and happiness. After the economic crises of 2013, there was a boost, and after the pandemic, there is again a boost in research. More than half of the publications and citations on female entrepreneurship and happiness management are post-pandemic. The study offers some research directions and emphasises the role of gender.Originality/valueThis article brings a new approach to the study of well-being in organisations, highlighting the relevance of the role female leadership plays in promoting happiness at work.
Rethinking sustainability in cocoa supply chain in light of SDG disclosure
Authors: Martins Flávio P. , Batalhão André C.S. , Ahokas Minna , Liboni Amui Lara Bartocci , Cezarino Luciana O. 
Published: September 2023

Purpose
This paper aims to assess how cocoa supply chain companies disclose sustainable development goals (SDGs) information in their sustainability reports. This assessment highlights strategic aspects of sustainable supply chain management and reveals leveraging sustainability points in the cocoa industry.

Design/methodology/approach
The two-step qualitative approach relies on text-mining company reports and subsequent content analysis that identifies the topics disclosed and relates them to SDG targets.

Findings
This study distinguishes 18 SDG targets connected to cocoa traders and 30 SDG targets to chocolate manufacturers. The following topics represent the main nexuses of connections: decent labour promotion and gender equity (social), empowering local communities and supply chain monitoring (economic) and agroforestry and climate action (environmental).

Practical implications
By highlighting the interconnections between the SDGs targeted by companies in the cocoa supply chain, this paper sheds light on the strategic SDGs for this industry and their relationships, which can help to improve sustainability disclosure and transparency. One interesting input for companies is the improvement of climate crisis prevention, focusing on non-renewable sources minimisation, carbon footprint and clear indicators of ecologic materiality.

Social implications
This study contributes to policymakers to enhance governance and accountability of global supply chains that are submitted to different regulation regimes.

Originality/value
To the best of the authors’ knowledge, no previous study has framed the cocoa industry from a broader SDG perspective. The interconnections identified reveal the key goals of the cocoa supply chain and point to strategic sustainability choices for companies in an important global industry.
Predicting cause-related marketing patronage intentions, corporate social responsibility motives and moderating role of spirituality
Authors: Suryavanshi A.K.S. , Bhatt Viral , Thomas Sujo , Patel Ritesh , Jariwala Harsha 
Published: September 2023

Purpose
Recent studies have observed rise in consumer’s ethical concerns about the online retailers while making a purchase decision. The impetus for businesses to use corporate social responsibility (CSR) is evident, but the effects of CSR motives on corresponding processes underlying cause-related marketing (CRM) patronage intention have not been thoroughly examined. This study, anchored on attribution theory, established a research model that better explains the influence of CSR motives on patronage intentions toward CRM-oriented online retailers. Additionally, this study aims to examine the moderating role of spirituality (SPT) on CSR motives and CRM patronage intention (CPI).

Design/methodology/approach
Primary data has been collected from 722 respondents and analyzed by using deep neural-network architecture by using the innovative PLS-SEM-ANN method to predict/rank the factors impacting CPI.

Findings
The results revealed the normalized importance of the predictors of CPI and found that value-driven motive was the strongest predictor, followed by strategic motive, SPT, age and stakeholder-driven motive. In contrast, egoistic motive, education and income were found insignificant.

Originality/value
The pandemic has transformed the way consumers shop and fortified the online economy, thereby resulting in a paradigm shift toward usage of e-commerce platforms. The results offer valuable insights to online retailers and practitioners for predicting patronage intentions by CSR motives and, thus, effectively engage CRM consumers by designing promotions in a way that would deeply resonate with them. This study assessed and predicted the factors influencing the CPI s, thereby guiding the online retailers to design CSR strategies and manage crucial CRM decisions.
Drosophila X virus‐like particles as delivery carriers for improved oral insecticidal efficacy of scorpion Androctonus australis peptide against the invasive fruit fly, Drosophila suzukii
Authors: Xue Qi , Swevers Luc , Taning Clauvis Nji Tizi 
Published: September 2023

AbstractInsect‐specific neurotoxic peptides derived from the venoms of scorpions and spiders can cause acute paralysis and death when injected into insects, offering a promising insecticidal component for insect pest control. However, effective delivery systems are required to help neurotoxic peptides pass through the gut barrier into the hemolymph, where they can act. Here, we investigated the potential of a novel nanocarrier, Drosophila X virus‐like particle (DXV‐VLP), for delivering a neurotoxin from the scorpion Androctonus australis Hector (AaIT) against the invasive pest fruit fly, Drosophila suzukii. Our results show that the fusion proteins of DXV polyproteins with AaIT peptide at their C‐termini could be sufficiently produced in Lepidoptera Hi5 cells in a soluble form using the recombinant baculovirus expression system, and could self‐assemble into VLPs with similar particle morphology and size to authentic DXV virions. In addition, the AaIT peptides displayed on DXV‐VLPs retained their toxicity, as demonstrated in injection bioassays that resulted in severe mortality (72%) in adults after 72 h. When fed to adults, mild mortality was observed in the group treated with DXV‐AaIT (38%), while no mortality occurred in the group treated with AaIT peptide, thus indicating the significant role of DXV‐VLPs in delivering AaIT peptides. Overall, this proof‐of‐concept study demonstrates for the first time that VLPs can be exploited to enhance oral delivery of insect‐specific neurotoxic peptides in the context of pest control. Moreover, it provides insights for further improvements and potentially the development of neurotoxin‐based bioinsecticides and/or transgenic crops for insect pest control.
Formulation of pasta enriched with protein‐rich lupine (Lupinus mutabilis Sweet) and wheat bran using mixture design approach
Authors: Karoui Iness Jabri , Terras Dorra Sfayhi , Yeddes Walid , Hammami Majdi , Abderrabba Manef 
Published: September 2023

AbstractIn recent years, as awareness of healthy diets has increased, consumers are becoming more aware of their food and are paying more attention to their diet. Nutritionists have recommended an increased consumption of dietary fiber in the daily diet to improve health. Within this context, this work aims to formulate “spaghetti” pasta enriched with lupin flour and wheat bran. For the formulation of the mixture of those flours, we used the NemrodW software to predict the optimal pasta formula. A physicochemical characterization, as well as the culinary quality of the pasta resulting from the different mixtures, was carried out to model each significant criterion and choose the optimal mixture that will be used in the pasta recipe. The evaluation of the physicochemical characteristics of the pasta showed that the addition of lupin flour and bran resulted in an improvement in the nutritional value of the enriched spaghetti. Following the results obtained, the software proposed an optimal mix and will be used for further study. This formula comprises 19.60% bran, 27.83% lupin flour, and 52.75% durum wheat semolina. The caloric value of the dough from the optimal mix was determined and compared to that of the standard dough. The results of our study indicated a significant improvement in the nutritional value of the enriched pasta compared to the standard pasta. The enriched pasta contained higher levels of protein, ash, lipids, polyphenols, and pigments and lower levels of sugars, which make it a more nutritious option for certain individuals, such as athletes or those following a protein or low‐sugar diet.Practical ApplicationThe proposed method of substituting wheat semolina with lupine flour and wheat bran in spaghetti formulation has demonstrated a potential for producing protein‐rich and nutritionally enriched pasta. This approach can be useful for developing similar functional food products that cater to the dietary requirements of athletes or individuals following a protein or low‐sugar diet.