bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dinamika Populasi Ikan Gulamah Batu (Johnius trachycephalus) di Perairan Sungai Barumun Kecamatan Panai Hilir Kabupaten Labuhan Batu
Authors: Dalimunthe Khairunnisa , Machrizal Rusdi 
Published: March 2023

Ikan gulamah batu (Johnius trachycephalus) merupakan salah satu ikan yang habitatnya berada di perairan sungai barumun. Ikan (J. trachycephalus) adalah salah satu jenis ikan bernilai ekonomis dengan harga jual antara 15.000-25.000 kg. Penelitian ini bertujuan untuk mengetahui dinamika populasi ikan gulamah batu yang ada di perairan sungai barumun Kabupaten Labuhanbatu. Pengambilan sampel ikan gulamah batu dilaksanakan sebanyak 3 kali dimulai Oktober- Desember 2021, Lokasi pengambilan sampel dibagi menjadi 3 stasiun pengamatan, masing-masing berada pada 2°38'49.08"N; 100°6'30.23"E (Stasiun1), 2°37'22.94"N; 100°7'2.33"E (Stasiun 2), 2°36'50.29"N; 100°5'56.95"E (Stasiun 3) Penangkapan ikan mengunakan alat tangkap berupa gill net di tebar sebanyak satu kali dalam satu hari, kemudian ikan yang ditangkap diukur panjang total, panjang standar, menggunakan jangka sorong dengan (akurasi 0,1 mm) serta berat ikan gulamah dengan menggunakan alat timbangan digital dengan (akurasi 0,1 g). Data hasil penelitian dalam bentuk grafik menggunakan program Microsoft Excel 2021. Berdasarkan hasil penelitian jumlah ikan (J. trachycephalus) sebanyak 66 ekor, menunjukan pola pertumbuhan ikan gulamah (J. trachycephalus) bersifat allometrik negatif dengan nilai b = 1,2046 dan R2= 0,5316, Parameter pertumbuhan menunjukan nilai L∞, K dan t0 menggunakan model pertumbuhan von bertalanffy faktor pertumbuhan (K) sebesar 0,680 per-tahun, nilai panjang asimotrik L∞ adalah 18,20 cm, dengan nol (t0) adalah 0,098. Oleh karena itu, persamaan pertumbuhan memiliki nilai Lt = 18,20 (1-e -0,680 Lt+0,098).
Uji Efektivitas Biodegradasi Larva Kumbang Mealworm (Tenebrio molitor) terhadap Limbah Plastik LDPE dan Styrofoam
Authors: Oktari Anita , Aprilani Mira , Pudjiastuti Dinar Rahaju , Fadhila Fanny 
Published: March 2023

Limbah kemasan plastik dan Styrofoam dapat membebani alam karena sulit terurai di tanah menjadikan limbah yang dihasilkannya akan mengalami penumpukan terus menerus sehingga mencemari lingkungan. Oleh karena itu peneliti ingin melakukan penelitian serupa untuk menguji dan membuktikan kembali efektivitas larva kumbang mealworm (Tenebrio molitor) dalam memecah polimer polistirena serta pada polimer polietilena. Jenis penelitian yang digunakan adalah penelitian eksperimen. 2 polimer plastik berukuran 5x5 cm di letakkan pada 3 cawan yang memilki jumlah ulat yang berbeda (0, 50, 100) sebanyak 7 kali pengulangan di setiap perlakuan. Hasil penelitian menunjukkan bahwa ada penurunan berat plastik LDPE oleh 50 larva sebesar 2,36±0,043% dan 100 larva sebesar 3,81±0,472%. Penurunan plastik styrofoam oleh 50 larva sebesar 27,08±0,89% dan 100 larva sebesar 67,88±1,09%. Hal ini membuktikan bahwa larva kumbang mealworm dapat mendegradasi plastik LDPE dan Styrofoam dalam waktu 2 hari. Dengan tingkat efektivitas biodegradasi pada Styrofoam 11x lebih efektif dibandingkan pada plastik LDPE dengan menggunakan 50 larva kumbang mealworm dan efektivitas biodegradasi pada Styrofoam 18x lebih efektif dibandingkan pada plastik LDPE dengan menggunakan 100 larva kumbang mealworm selama 2 hari. Berdasarkan data tersebut, tidak menutup kemungkinan bahwa larva kumbang mealworm juga dapat melakukan proses biodegredasi pada polimer plastik lainnya.
Casais sorodiferentes: vivência e conflitos
Authors: Farias Kassiara Ferreira Felix de Lima , Santos Amuzza Aylla Pereira dos , Silva Nathalia Lima da , Santos Mirelle dos , Tavares Núbia Vanessa da Silva 
Published: March 2023

Objetivo: Analisar a vivência da conjugalidade de casais sorodiferentes marcada pelo enfrentamento de conflitos em decorrência ao vírus da imunodeficiência humana. Métodos: Trata-se de um estudo descritivo, de natureza qualitativa, relacionado a percepção dos casais sorodiferentes sobre o enfrentamento do HIV. A coleta de dados se deu por meio de entrevista semiestruturada de forma presencial e através da plataforma online, realizada com oito casais, na qual apenas um dos parceiros que compõem o casal possui diagnóstico positivo para o HIV. A realização da pesquisa ocorreu em um hospital universitário do nordeste brasileiro, referência para pessoas com HIV/AIDS. Resultados: O preconceito e a vivência do sigilo foram os desafios mais citados pelos entrevistados, visto que muitos casais preferem viver o segredo do diagnóstico do que correr o risco de sofrer o preconceito social, alegando inclusive que não vivenciam o preconceito porque a condição de saúde não é sabida pelas pessoas do seu meio social. Conclusão: Evidencia-se que a conjugalidade dos casais sorodiferentes apresenta variados desafios em sua vivência, como: o estigma social da doença, a falta de compromisso das pessoas que vivem com o vírus em aderirem ao uso regular da terapia antirretroviral somados ao medo da transmissão viral.
The mechanism of oxidative stress in keloid fibroblasts and the experimental study of early application of angiotensin-converting enzyme inhibitor
Authors: Hong Li , Junjie Chen , Pengyu Zhao , Ping Liu , Wei Chen 
Published: March 2023

Objective
To investigate the protective effects of an angiotensin-converting enzyme inhibitor after inducing oxidative stress on keloid fibroblasts.

Methods
Primary keloid fibroblasts were isolated and cultured by enzyme digestion combined with the tissue adhesion method in vitro, and the third to fifth generations of cells were selected for the experiment. For 24 hours, keloid fibroblasts were treated with different concentrations of hydrogen peroxide. Different concentrations of angiotensin-converting enzyme inhibitor were added to the keloid fibroblast culture medium, and then the cells were treated with hydrogen peroxide for 24 hours.

Results
With the increase of hydrogen peroxide concentration, the growth of keloid fibroblasts was inhibited and the levels of malondialdehyde, superoxide dismutase, and reactive oxygen species increased gradually, accompanied by an increase in the expression of nicotinamide adenine dinucleotide phosphate oxidase and collagen I mRNA. The expression of nicotinamide adenine dinucleotide phosphate oxidase-mRNA in keloid fibroblasts and the formation of reactive oxygen species in keloid fibroblasts were induced by different concentrations of angiotensin II, and the most significant effect was at 10–5 mmol/mL. The effects of diphenyleneiodonium chloride (NOX inhibitor), N-acetylcysteine (reactive oxygen species inhibitor) and nicotinamide adenine dinucleotide phosphate oxidase (NADPH oxidase) RNA treatment on angiotensin II-induced nicotinamide adenine dinucleotide phosphate oxidase and collagen I increased significantly. Hydrogen peroxide and angiotensin II alone or combined can induce NADPH oxidase and reactive oxygen species expression in keloid fibroblasts. When the angiotensin-converting enzyme inhibitor was added, the expression of NADPH oxidase and reactive oxygen species in keloid induced by hydrogen peroxide and angiotensin II could be inhibited.

Conclusion
Oxidative stress can lead to increased expression of reactive oxygen species, NADPH oxidase and collagen I in keloid fibroblasts, suggesting oxidative stress mediates the migration of human keloid fibroblasts and extracellular matrix synthesis.
Efficacy and safety of Saroglitazar and Fenofibrate in the treatment of diabetic dyslipidaemia: A pilot study
Authors: Gahlot Rahul , Kumar Sahil , Garg Sandeep , Chawla Shalini , Kalra Bhupinder Singh 
Published: March 2023

Objectives:
Diabetic dyslipidaemia (DD) is characterised by hypertriglyceridaemia and elevated or normal levels of low-density lipoprotein cholesterol and decreased levels of high-density lipoprotein cholesterol with Type 2 diabetes mellitus. Statins and anti-diabetic medication are coprescribed for optimal control.

Materials and Methods:
The objective of the study was to compare the safety and efficacy of Saroglitazar 4-mg and Fenofibrate 200 mg in combination with low dose Atorvastatin (10 mg) in patients with DD. Run-in period of 4 weeks for life-style and diet modification followed by 12 weeks of treatment with saroglitazar or fenofibrate and low dose of atorvastatin was followed. Primary outcome of this study was an absolute change in serum triglyceride level at baseline and end of treatment period (12 weeks). Secondary outcome was changed from baseline lipid profile, fasting blood glucose and glycosylated haemoglobin (HbA1c) at the end of treatment period. Safety assessment was also done during the duration of study.

Results:
Forty patients of DD were randomly divided into two groups. One group received Saroglitazar 4 mg along with Atorvastatin 10 mg. Patients in second group received Fenofibrate 200 mg along with Atorvastatin 10 mg. Improvement in deranged lipid levels in both the groups was observed and this difference in improvement statistically was not found to be significant. We also observed that Saroglitazar significantly improves glycaemic profile by decreasing fasting blood sugar levels and HbA1c (P = 0.01, P < 0.01). Adverse events reported during this study were mild and none of the patients reported serious adverse events.

Conclusion:
Saroglitazar could be a potential drug to control both hyperglycaemia and dyslipidaemia in patients with DD.
A cross-sectional survey to assess the drug disposal practices of unused and expired medicines among lay public visiting a tertiary care hospital in an urban metropolis
Authors: Munshi Renuka , Dhiman Alisha , Maurya Miteshkumar 
Published: March 2023

Objectives:
A cross-sectional survey was conducted to evaluate the knowledge, awareness and practice among the lay public regarding storage and disposal of unused and expired medicines.

Materials and Methods:
This was an observational, cross-sectional, single-centre and questionnaire-based survey. After obtaining Institutional Ethics Committee approval, the study was conducted using a pre-validated structured questionnaire distributed among the lay public visiting a tertiary care hospital located in an urban metropolitan city.

Results:
Four hundred of 720 individuals visiting the tertiary care hospital participated in the survey. The results revealed that 75% had never referred to any sources to get the correct information about the proper and safe disposal of medicines and had no knowledge regarding the same. About 12.75% of study participants reported that they were educated regarding the disposal of medicines by their treating physicians (RR: 0.71 [95% CI: 0.51–0.99]) when compared with the other sources of information (18%) with statistically significant contribution made by the physicians (p<0.05). About 67% of the public stored their medicines at room temperature. Majority (83.75%) of the study participants reported that they disposed unused and expired drugs in the dustbin. Only 42.5% of the public knew the detrimental effect of improper drug disposal on human health and our ecosystem. In addition, 80% (320/400) of the participants confirmed that, given the option, they would prefer to return the unused or expired drugs to the pharmacy shops from where the medicines were purchased.

Conclusion:
There is a need to educate drug consumers/general public about safe and proper disposal of unused/ expired medicines. Health-care professionals, governments and policymakers should offer training to educate the general public about Indian regulations for safe disposal of unused/expired medicines.
Heart rate variability in patients presenting with anginal symptoms in absence of cardiac and other diseases
Authors: Khadka Rita , Jaryal Ashok , Narang Rajiv , Patel Chetan , Pandey Ravindra Mohan , Deepak Kishore Kumar 
Published: March 2023

Objectives:
Angina is a symptom of coronary artery disease (CAD). Modulation of cardiac autonomic tone as assessed by heart rate (HR) variability (HRV) is found reduced in patients with CAD; myocardial ischemia, myocardial infarction and some other cardiovascular diseases. Reduced HRV has been found associated with sudden cardiac death in these CAD patients. Several patients present with anginal symptoms clinically in absence of CAD or other diseases. The status of HRV is not much clear in these patients. Thus, we aimed to assess HRV in patients with angina with and without myocardial ischemia and compare it with HRV of healthy subjects of similar age groups and follow-up patients for 1 year for cardiac/health events.

Materials and Methods:
The study included 61 consecutive male patients clinically presenting with angina and 30 healthy subjects. Based on Thallium-201 myocardial perfusion Single-photon emission computerized tomography (SPECT) imaging, patients were divided into two groups; patients with myocardial perfusion defects (MPD), (n = 33, age 54.91 ± 7.43 years) and patients with no MPD (NMPD), NMPD (n = 28, age 53.04 ± 8.50 years). Short-term HRV was assessed in all patients and subjects in resting supine position following standard protocol. All MPD and 25 NMPD patients could be followed up for 1 year for cardiac/health events.

Results:
Surprisingly, the NMPD patients showed significantly reduced HRV, Standard deviation of the N-N intervals, The square root of the mean squared differences of successive N-N intervals, Percentage of the number of interval differences of successive N-N intervals greater than >50 ms divided by total number of R-R intervals, low frequency (LF) power, High Frequency (HF) power and total power as compared to both MPD patients and healthy subjects. (Total power [NMPD vs. MPD]: 610.1 [379.9–1072.8] vs. 1508.0 [748.4–2339.4] millisecond squares (ms2), P = 0.001), healthy subjects (Total power: 1414.6 [1104.6-2141.5] ms2, P = 0.001). The markers of sympathetic tone; LF (normalised unit) and LF/HF ratio were higher in NMPD patients as compared to MPD patients resulting in an altered sympathovagal balance. During a 1-year follow-up, sudden death was seen in one MPD patient (3.1%) and two NMPD patients (8%).

Conclusion:
The NMPD patients showed significantly reduced HRV as compared to both MPD patients and Healthy subjects with an altered sympathovagal balance. Sudden death was also seen in NMPD patients as MPD patients.
Toward in silico Catalyst Optimization
Authors: Wodrich Matthew D. , Laplaza Ruben , Cramer Nicolai , Reiher Markus , Corminboeuf Clemence 
Published: March 2023

In this minireview, we overview a computational pipeline developed within the framework of NCCR Catalysis that can be used to successfully reproduce the enantiomeric ratios of homogeneous catalytic reactions. At the core of this pipeline is the SCINE Molassembler module, a graph-based software that provides algorithms for molecular construction of all periodic table elements. With this pipeline, we are able to simultaneously functionalizenand generate ensembles of transition state conformers, which permits facile exploration of the influencenof various substituents on the overall enantiomeric ratio. This allows preconceived back-of-the-envelope designnmodels to be tested and subsequently refined by providing quick and reliable access to energetically low-lyingntransition states, which represents a key step in undertaking in silico catalyst optimization.
PROBLEMATIC ISSUES OF CREATING ACCESSIBLE ENVIRONMENT FOR DISABLED PERSONS AND LOW-MOBILITY GROUPS OF POPULATION
Authors: Курганова К.И. 
Published: March 2023

В статье рассматривается проблема формирования доступной среды для инвалидов и маломобильных групп населения. Рассмотрено, как в рамках государственной программы «Доступная среда» повышается качество жизни инвалидов в современном российском обществе. С учетом проблемы неравных возможностей при использовании объектов социальной инфраструктуры в регионах для маломобильных групп населения, рассматривается предложение по обеспечению возможности равного доступа к учреждениям социальной и иной инфраструктуры для пользования общественными услугами. Перечислены проблемы, с которыми сталкиваются инвалиды в разных регионах. Предложено решение проблемы социального проектирования формирования доступной среды.
The article deals with a problematic issue of creating an accessible environment for disabled persons and low-mobility groups of population. It examines how the state supported programme «Accessible Environment» promotes for improving quality life for disabled people in today’s Russian society. Given the issue of unequal opportunities with regard to the use of social infrastructure facilities in the regions for people with limited mobility a proposal is being considered as to ensuring equal access to social and other related infrastructure institutions to enjoy public services. Key problems disable people face in different regions are enumerated. The author concludes with proposing a way of solving the challenge of social design for an accessible environment.
CONSUMER EXTREMISM AS A THREAT TO ECONOMIC SECURITY OF MODERN RUSSIA
Authors: Дмитриева Н.В. , Кудрявцев Ю.А. 
Published: March 2023

В статье рассмотрено понятие, выделены признаки и особенности проявления «потребительского экстремизма» в Российской Федерации. Обоснован вывод, согласно которому потребительский экстремизм можно рассматривать в качестве внутренней угрозы экономической безопасности не только конкретного хозяйствующего субъекта, но и государства в целом.
The article describes the concept of and highlights specific features of "consumer extremism" as well as particulars of the manifestation whereof in the Russian Federation. A reasonable conclusion is made whereby consumer extremism might be considered an internal threat to economic security not only of a particular economic entity, but also the one to the state as a whole.
ON LEGALITY OF ENTREPRENEURIAL TRANSACTIONS WITH REGARD TO FINANCIAL OBLIGATIONS TO STATE
Authors: Дикаев С.У. , Кузин Н.Н. , Шубников Ю.Б. 
Published: March 2023

В статье рассмотрены некоторые вопросы, связанные с правомерностью предпринимательских сделок в отношении финансовых обязательств перед государством, к которым относятся обязательные платежи в виде налогов и сборов. Также рассмотрены вопросы, связанные с деятельностью налоговой службы по выявлению подозрительных сделок в части касающейся уменьшения поступления платежей в бюджет по результатам предпринимательских договоров. Уделено внимание рассмотрению схем предпринимателей, позволяющих существенно уменьшить налоговую нагрузку в определённых условиях.
The article deals with the legality of business transactions disclosing financial obligations to the state, which include mandatory tax payments and fees. The paper also focuses on specific issues with direct relevance to tax administration activities aimed in particular at revealing suspicious transactions related to attempted reduction of resulting final payments to the budget in the course of performing business contracts. Special attention is paid to examining particular schemes of entrepreneurs which might enable to significantly reduce tax burdens under certain conditions.
OMBUDSMAN INSTITUTION IN POST SOVIET AREA
Authors: Беляцкая А.М. 
Published: March 2023

В данной статье автор анализирует нормы, регулирующие деятельность уполномоченных по правам человека в постсоветских странах. В ходе данного анализа автор делает вывод, что на постсоветском пространстве сложилась своя уникальная модель института уполномоченного по правам человека.
The article deals with the analysis of norms, regulating ombudsmen activities in the post Soviet countries. In the course of the analysis the author concludes that in the post-Soviet space there emerged its unique model of ombudsman institution.
INVATOURISTS AS SPECIAL CATEGORY OF TOURIST PRODUCT CONSUMERS
Authors: Карпова Г.А. , Валеева Е.О. 
Published: March 2023

Представлены основные результаты проведенного авторами исследования особенностей обслуживания инватуристов как особой категории потребителей туристского продукта на современном этапе. Систематизированы основные подходы к определению направления туризма, в рамках которого активное участие принимают туристы – лица с ограниченными возможностями здоровья (ОВЗ). На примере всероссийского проекта «Музейные маршруты России» – 2023 проанализирована доступность прохождения подобных маршрутов для инватуристов. На основании полученных выводов выявлено проблемное поле и сформулированы основные аспекты организации обслуживания туристов с ОВЗ.
We introduce the results of the research dedicated to serving invatourists as a special category of tourist product consumers at the present stage. We systemize the main approaches to defining the direction of tourism that enjoys popularity among handicapped tourists. We analyze the accessibility of itineraries for invatourists by the example of the national project “Museum Routes of Russia - 2023”. Based on the research, we reveal problems and specify the main aspects of attending handicapped tourists.
ON FINANCIAL STABILITY (SUSTAINABILITY) OF BANKING SYSTEM AND ITS ASSESSMENT
Authors: Кроливецкая В.Э. , Масловская Е.О. , Конников Е.А. 
Published: March 2023

В статье рассмотрены вопросы финансовой безопасности и финансовой стабильности в Российской Федерации в условиях внешних вызовов и угроз. Проведен анализ взаимосвязи содержания категорий «финансовая безопасность», «финансовая стабильность». Рассмотрены точки зрения на сущность этих категорий и дано авторское определение финансовой стабильности. Охарактеризованы показатели финансовой устойчивости банковской системы и способы ее расчета. Авторами также проведен расчет интегрального показателя финансовой устойчивости банковской системы Российской Федерации.
We look at certain issues of financial security and financial stability in the Russian Federation under external challenges and threats. We analyze the correlation between the concepts of financial security and financial stability. Various points of view on the essence of the categories in question are considered; we introduce our own definition of financial stability. Indicators of financial stability of the banking system and methods of its calculation are characterized. We also calculate the integral indicator of financial stability of the banking system of the Russian Federation.
ON FURTHER DEVELOPMENT OF MORTGAGE HOUSING CREDIT IN RUSSIA
Authors: Солдатенкова И.В. 
Published: March 2023

В статье проведен анализ динамики основных показателей развития рынка ипотечного жилищного кредитования в России в 2021–2022 гг. Выделены факторы, которые, по мнению автора, будут сдерживать расширение этого сегмента в краткосрочной перспективе. Сформулированы авторские рекомендации в части корректировки правительством дальнейших направлений развития рынка с целью повышения доступности ипотечного жилищного кредитования в России.
We analyze the dynamics of the key indicators of Russian mortgage market in 2021-2022. We distinguish certain factors that in our opinion will restrain the expansion of the segment in question in the short term. We present our recommendations concerning further corrections to be made by the government in order to increase the affordability of mortgage in Russia.