bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neonatal admission after lithium use in pregnant women with bipolar disorders: a retrospective cohort study
Authors: Schonewille Noralie N. , Terpstra Pleun A. , van den Heuvel Maria E. N. , Van Pampus Maria G. , van den Heuvel Odile A. , Broekman Birit F. P. 
Published: July 2023

Abstract
Background
Lithium is the preferred treatment for pregnant women with bipolar disorders (BD), as it is most effective in preventing postpartum relapse. Although it has been prescribed during pregnancy for decades, the safety for neonates and obstetric outcomes are a topic of ongoing scientific debate as previous research has yielded contradicting outcomes. Our study aims to compare (re)admission rates and reasons for admissions in neonates born to women with bipolar disorders (BD) with and without lithium exposure.

Methods
A retrospective observational cohort study was conducted in a Dutch secondary hospital (two locations in Amsterdam). Women with BD who gave birth after a singleton pregnancy between January 2011 and March 2021 and their neonates were included. Outcomes were obtained by medical chart review of mothers and neonates and compared between neonates with and without lithium exposure. The primary outcome was admission to a neonatal ward with monitoring, preterm birth, small for gestational age (SGA), 5-minute Apgar scores, neonatal asphyxia, and readmission ≤ 28 days.

Results
We included 93 women with BD, who gave birth to 117 live-born neonates: 42 (36%) exposed and 75 (64%) non-exposed to lithium. There were no significant differences in neonatal admission with monitoring (16.7 vs. 20.0%, p = 0.844). Additionally, preterm birth (7.1 vs. 5.3%), SGA (0.0 vs. 8.0%), 5-minute Apgar scores (means 9.50 vs. 9.51), neonatal asphyxia (4.8 vs. 2.7%) and readmission (4.8 vs. 5.3%) were comparable. Overall, 18.8% of BD offspring was admitted. Women with BD had high rates of caesarean section (﻿29.1%), gestational diabetes (12.8%) and hypertensive disorders of pregnancy (8.5%).

Conclusions
In a sample of neonates all born to women with BD using various other psychotropic drugs, exposure to lithium was not associated with greater risk of neonatal admission to a ward with monitoring compared to non-exposure to lithium, questioning the necessity for special measures after lithium exposure. However, offspring of women with BD was admitted regularly and women with BD have high obstetric risk which require clinical and scientific attention.
Psychometric evaluation of the depression, anxiety, and stress scale-21 (DASS-21) among Chinese primary and middle school teachers
Authors: Cao Cui-Hong , Liao Xiao-Ling , Jiang Xing-Yong , Li Xu-Dong , Chen I-Hua , Lin Chung-Ying 
Published: July 2023

AbstractBackgroundTeachers in high-stress roles face increasing psychological distress such as anxiety and depression, underscoring the need for validated assessment instruments. Given the current absence of a comprehensive, designated, and time-efficient scale capable of evaluating depression, anxiety, and stress among the teacher population, the Depression, Anxiety, and Stress Scale-21 (DASS-21) presents itself as a promising alternative. Despite the widespread application of the DASS-21 for assessing psychological distress across various populations, its validity among teachers, along with questions about its factor structure and its potential property of time equivalence, remain unverified. This study endeavors to address these considerations by investigating the psychometric properties of the DASS-21 specifically within the population of Chinese primary and middle school teachers.MethodsCross-sectional (n = 9,030) and longitudinal surveys (n = 1,642) were conducted using a non-probability sampling method. In addition to the DASS-21, the Chinese version of Chinese Teachers’ Job Burnout Questionnaire (CTJBO) was utilized to evaluate the criterion validity of this scale. Three different approaches, namely confirmatory factor analysis, Rasch analysis, and network analysis, were employed to evaluate internal reliability, construct validity, as well as time invariance of the DASS-21.ResultsThe DASS-21 demonstrated a high degree of internal consistency (Cronbach’s α > 0.85) as well as excellent convergent validity, despite poor discriminant validity as determined by average variance extracted. Confirmatory factor analysis and network analysis further supported convergent validity. The three-factor structure outperformed one- and two-factor alternatives, establishing time invariance. Rasch analysis at the item level identified six inappropriate items within the anxiety and stress subscales, which were subsequently removed. Network analysis presented a better revised network. Regression analysis with emotional exhaustion as the criterion provided logical and accurate results.ConclusionThe DASS-21 was found to be a reliable and valid tool for measuring the mental health of teachers over time. To assess the instrument’s psychometric properties, a combination of confirmatory factor analysis, Rasch analysis, and network analysis was utilized, which proved effective and is recommended for evaluating contentious instruments. Based on the results of the study, researchers and healthcare professionals are recommended to use the DASS-21 for assessing teachers’ psychological distress. However, certain items identified in the study may need to be removed to enhance the instrument’s appropriateness for this specific population.
Xylaria species associated with fallen leaves and petioles
Authors: Ju Yu-Ming , Hsieh Huei-Mei 
Published: July 2023

Abstract
Background
Xylaria species growing on fallen leaves and petioles have not been treated systematically. One source of confusion in this group of Xylaria species has stemmed from X. filiformis, which is an ancient name published in 1805 as Sphaeria filiformis and has commonly labeled on specimen packets that contain leaf- and petiole-inhabiting Xylaria species. Here we clarified the identity of X. filiformis and distinguish it from the species that are easily confused with it, notably X. simplicissima, to which most specimens labeled as X. filiformis are referred. Our research also led us to encounter many other leaf- and petiole-inhabiting Xylaria species, prompting a comprehensive study of this group of fungi.

Results
Forty-five foliicolous and caulicolous species of Xylaria were studied, including nine newly described species—X. allima, X. appendiculatoides, X. hispidipes, X. minuscula, X. neblinensis, X. spiculaticlavata, X. vermiformis, X. vittatipiliformis, and X. vittiformis; three unnamed species—X. sp. AR1741, X. sp. GS7461A, and X. sp. GS7461B; X. simplicissima, a name newly combined with Xylaria from Rhizomorpha simplicissima; and X. noduliformis and X. imminuta, which are two new replacement names, respectively, for X. maitlandii var. nuda and X. hypsipoda var. microspora. The 45 taxa can be classified into three groups by stromatal shape and conspicuousness of perithecial mounds on the stromatal surface: (i) the X. filiformis group contains 10 species, (ii) the X. phyllocharis group contains 19 species, and (iii) the X. heloidea group contains 16 species. One of the newly described or unnamed species belongs to the X. filiformis group—X. vermiformis; nine of them belong to the X. phyllocharis group—X. allima, X. appendiculatoides, Xylaria minuscula, X. neblinensis, X. sp. AR1741, X. sp. GS7461B, X. spiculaticlavata, X. vittatipiliformis, and X. vittiformis; and three of them belong to the X. heloidea group—X. hispidipes, X. imminuta, and X. sp. GS7461A.

Conclusion
The 45 species of Xylaria associated with fallen leaves and petioles can be identified by using the dichotomous identification key that we provided herein. It is important to note that most of the studied species are represented by only one or several specimens and many have not been recollected and cultured.
Enormously large tippers observed in southwest China: can realistic 3-D EM modeling reproduce them?
Authors: Xu Shan , Chen Chaojian , Kruglyakov Mikhail , Kuvshinov Alexey , Rigaud Rafael , Hu Xiangyun 
Published: July 2023

Abstract
Vertical magnetic transfer functions (tippers) estimated at a global/continental net of geomagnetic observatories/sites can be used to image the electrical conductivity structure of the Earth’s crust and upper mantle (down to around 200 km). We estimated tippers at 54 geomagnetic observatories across China, aiming eventually to invert them in terms of subsurface three-dimensional (3-D) conductivity distribution. Strikingly, we obtained enormously large tippers at three inland observatories in southwest China. Large tippers are often observed at coastal/island observatories due to high conductivity contrasts between resistive bedrock and conductive seawater. However, tippers at those inland observatories appeared to be a few times larger than coastal/island tippers. As far as we know, such large tippers (reaching value 3) were never reported in any region worldwide. We perform electromagnetic simulations in 3-D conductivity models mimicking the geological setting and demonstrate that enormously large tippers are feasible and can be attributed to a current channeling effect.

Graphical Abstract
Different photosynthetic responses of haploid and diploid Emiliania huxleyi (Prymnesiophyceae) to high light and ultraviolet radiation
Authors: Ruan Zuoxi , Lu Meifang , Lin Hongmin , Chen Shanwen , Li Ping , Chen Weizhou , Xu Huijuan , Qiu Dajun 
Published: July 2023

Abstract
Solar radiation varies quantitatively and qualitatively while penetrating through the seawater column and thus is one of the most important environmental factors shaping the vertical distribution pattern of phytoplankton. The haploid and diploid life-cycle phases of coccolithophores might have different vertical distribution preferences. Therefore, the two phases respond differently to high solar photosynthetically active radiation (PAR, 400–700 nm) and ultraviolet radiation (UVR, 280–400 nm). To test this, the haploid and diploid Emiliania huxleyi were exposed to oversaturating irradiance. In the presence of PAR alone, the effective quantum yield was reduced by 10% more due to the higher damage rate of photosystem II in haploid cells than in diploid cells. The addition of UVR resulted in further inhibition of the quantum yield for both haploid and diploid cells in the first 25 min, partly because of the increased damage of photosystem II. Intriguingly, this UVR-induced inhibition of the haploid cells completely recovered half an hour later. This recovery was confirmed by the comparable maximum quantum yields, maximum relative electron transport rates and yields of the haploid cells treated with PAR and PAR + UVR. Our data indicated that photosynthesis of the haploid phase was more sensitive to high visible light than the diploid phase but resistant to UVR-induced inhibition, reflecting the ecological niches to which this species adapts.

Graphical Abstract
Innovativeness in tradition: a study on the physical performance of leather scale armors during the Joseon Dynasty
Authors: Park Ga Young , Lee Han Bi , Oh Yuree , Lim Jung Ah , Lee Min Wook 
Published: July 2023

AbstractDuring the Joseon Dynasty, light and convenient leather armors were developed to replace metal armors, which were heavy and difficult to manufacture. Leather armors allowed easy movement of the troops and, because arrows were the primary weapons at the time, provided them with protection. The excellent performance of leather armors can be attributed to their materials and manufacturing method. The scales of the leather armor relics are prepared by layering animal skins, attaching them with natural glue, and then coating their outer surface with lacquer. The lacquer extracted from the lacquer (Ott) tree is an excellent material with high strength, waterproofing and antiseptic properties, insect repellency, heat resistance, as well as chemical resistance. The superior performance of the leather scale was reported in old scripts; however, it has not been proven through scientific analysis and testing. Therefore, in this study, the physical and mechanical properties, impact resistance, and anti-stab performance of leather scales manufactured following the traditional method were investigated. The results confirmed the excellent protection, impact resistance, and mechanical properties of the leather specimens glued with fish glue and coated with lacquer compared to those of specimens glued with synthetic glue and uncoated specimens glued with fish glue. This study reveals the excellent properties of fish glue and lacquer, which enable them to be used in various industries.
Activatable fluorescent probes for imaging and diagnosis of rheumatoid arthritis
Authors: Luo Pan , Gao Fu-Qiang , Sun Wei , Li Jun-You , Wang Cheng , Zhang Qing-Yu , Li Zhi-Zhuo , Xu Peng 
Published: July 2023

AbstractRheumatoid arthritis (RA) is a systemic autoimmune disease that is primarily manifested as synovitis and polyarticular opacity and typically leads to serious joint damage and irreversible disability, thus adversely affecting locomotion ability and life quality. Consequently, good prognosis heavily relies on the early diagnosis and effective therapeutic monitoring of RA. Activatable fluorescent probes play vital roles in the detection and imaging of biomarkers for disease diagnosis and in vivo imaging. Herein, we review the fluorescent probes developed for the detection and imaging of RA biomarkers, namely reactive oxygen/nitrogen species (hypochlorous acid, peroxynitrite, hydroxyl radical, nitroxyl), pH, and cysteine, and address the related challenges and prospects to inspire the design of novel fluorescent probes and the improvement of their performance in RA studies.
PTPRZ1-METFUsion GENe (ZM-FUGEN) trial: study protocol for a multicentric, randomized, open-label phase II/III trial
Authors: Bao Zhaoshi , Li Shouwei , Wang Liang , Zhang Bisi , Zhang Peilong , Shi Hepeng , Qiu Xiaoguang , Jiang Tao 
Published: July 2023

Abstract
Background
PTPRZ1-MET fusion was reported to associate with glioma progression from low-grade to high-grade glioma, which was a target by a MET inhibitor vebreltinib. However, little is known about the further efficacy of vebreltinib among more glioma patients. This trial aims to evaluate the safety and efficacy of vebreltinib enteric-coated capsules in the treatment of sGBM/IDH mutant glioblastoma patients with the ZM fusion gene.

Methods
This multicentric, randomized, open-label, controlled trial plans to include 19 neurosurgical centers and recruit 84 sGBM or IDH mutant glioblastoma patients with the ZM fusion gene. This trial enrolls sGBM or IDH mutant glioblastoma patients with the inclusion criteria and without the exclusion criteria. It was registered with chinadrugtrials.org.cn (CTR20181664). The primary efficacy endpoint is overall survival (OS). The secondary endpoints are progression-free survival (PFS) and objective response rate (ORR).

Discussion
If proven effective, this targeted multifaceted intervention protocol will be extended for more glioma patients as a protocol to evaluate the safety and efficacy of MET inhibitors.

Trial registration
It was registered with chinadrugtrials.org.cn (CTR20181664).
ALKBH5-mediated m6A demethylation fuels cutaneous wound re-epithelialization by enhancing PELI2 mRNA stability
Authors: Huang Xin , Zhao Yixuan , Liu Daiming , Gu Shuchen , Liu Yunhan , Khoong Yimin , Luo Shenying , Zhang Zewei , Xia Wenzheng , Wang Meng , Liang Hsin , Li Minxiong , Li Qingfeng , Zan Tao 
Published: July 2023

Abstract

Background
Impaired wound re-epithelialization contributes to cutaneous barrier reconstruction dysfunction. Recently, N6-methyladenosine (m6A) RNA modification has been shown to participate in the determination of RNA fate, and its aberration triggers the pathogenesis of numerous diseases. Howbeit, the function of m6A in wound re-epithelialization remains enigmatic.

Methods
Alkbh5‒/‒ mouse was constructed to study the rate of wound re-epithelialization after ALKBH5 ablation. Integrated high-throughput analysis combining methylated RNA immunoprecipitation sequencing (MeRIP-seq) and RNA-seq was used to identify the downstream target of ALKBH5. In vitro and in vivo rescue experiments were conducted to verify the role of the downstream target on the functional phenotype of ALKBH5-deficient cells or animals. Furthermore, the interacting reader protein and regulatory mechanisms were determined through RIP-qPCR, RNA pull–down, and RNA stability assays.

Results
ALKBH5 was specifically upregulated in the wound edge epidermis. Ablation of ALKBH5 suppressed keratinocyte migration and resulted in delayed wound re-epithelialization in Alkbh5‒/‒ mouse. Integrated high-throughput analysis revealed that PELI2, an E3 ubiquitin protein ligase, serves as the downstream target of ALKBH5. Concordantly, exogenous PELI2 supplementation partially rescued keratinocyte migration and accelerated re-epithelialization in ALKBH5-deficient cells, both in vitro and in vivo. In terms of its mechanism, ALKBH5 promoted PELI2 expression by removing the m6A modification from PELI2 mRNA and enhancing its stability in a YTHDF2-dependent manner.

Conclusions
This study identifies ALKBH5 as an endogenous accelerator of wound re-epithelialization, thereby benefiting the development of a reprogrammed m6A targeted therapy for refractory wounds.

Graphical Abstract
Implementing shared decision making for early-stage breast cancer treatment using a coproduction learning collaborative: the SHAIR Collaborative protocol
Authors: Schubbe Danielle , Yen Renata W. , Leavitt Hannah , Forcino Rachel C. , Jacobs Christopher , Friedman Erica B. , McEvoy Maureen , Rosenkranz Kari M. , Rojas Kristin E. , Bradley Ann , Crayton Eloise , Jackson Sherrill , Mitchell Myrtle , O’Malley A. James , Politi Mary , Tosteson Anna N. A. , Wong Sandra L. , Margenthaler Julie , Durand Marie-Anne , Elwyn Glyn 
Published: July 2023

Abstract
Background
Shared decision making (SDM) in breast cancer care improves outcomes, but it is not routinely implemented. Results from the What Matters Most trial demonstrated that early-stage breast cancer surgery conversation aids, when used by surgeons after brief training, improved SDM and patient-reported outcomes. Trial surgeons and patients both encouraged using the conversation aids in routine care. We will develop and evaluate an online learning collaborative, called the SHared decision making Adoption Implementation Resource (SHAIR) Collaborative, to promote early-stage breast cancer surgery SDM by implementing the conversation aids into routine preoperative care. Learning collaboratives are known to be effective for quality improvement in clinical care, but no breast cancer learning collaborative currently exists.
Our specific aims are to (1) provide the SHAIR Collaborative resources to clinical sites to use with eligible patients, (2) examine the relationship between the use of the SHAIR Collaborative resources and patient reach, and (3) promote the emergence of a sustained learning collaborative in this clinical field, building on a partnership with the American Society of Breast Surgeons (ASBrS).

Methods
We will conduct a two-phased implementation project: phase 1 pilot at five sites and phase 2 scale up at up to an additional 32 clinical sites across North America. The SHAIR Collaborative online platform will offer free access to conversation aids, training videos, electronic health record and patient portal integration guidance, a feedback dashboard, webinars, support center, and forum. We will use RE-AIM for data collection and evaluation. Our primary outcome is patient reach. Secondary data will include (1) patient-reported data from an optional, anonymous online survey, (2) number of active sites and interviews with site champions, (3) Normalization MeAsure Development questionnaire data from phase 1 sites, adaptations data utilizing the Framework for Reporting Adaptations and Modifications-Extended/-Implementation Strategies, and tracking implementation facilitating factors, and (4) progress on sustainability strategy and plans with ASBrS.

Discussion
The SHAIR Collaborative will reach early-stage breast cancer patients across North America, evaluate patient-reported outcomes, engage up to 37 active sites, and potentially inform engagement factors affecting implementation success and may be sustained by ASBrS.
The Rapid interaction: a qualitative study of provider approaches to implementing Rapid ART
Authors: Moran Lissa , Koester Kimberly A. , Le Tourneau Noelle , Coffey Susa , Moore Kelvin , Broussard Janessa , Crouch Pierre-Cedric , VanderZanden Lyndon , Schneider John , Lynch Elizabeth , Roman Jorge , Christopoulos Katerina A. 
Published: July 2023

Abstract
Background
Offering antiretroviral therapy (ART) to patients directly following an HIV diagnosis (“Rapid ART”) improves clinical outcomes and is feasible and acceptable for patients and providers. Despite this, implementation of Rapid ART is not yet standard practice in the USA. Structural-level implementation guidance is available, but research at the individual provider level that explores the patient-provider interaction itself remains scarce. The Consolidated Framework for Implementation Research (CFIR) provides a nuanced guide to investigating the less visible, more social elements of implementation like the knowledge and feelings of people, and the influences of culture and resources on individual approaches.

Methods
We conducted a multi-site qualitative study, exploring intervention commonalities across three HIV clinic environments: an HIV primary care clinic; an HIV/STI testing, treatment, and prevention clinic; and a large federally qualified health center (FQHC). Qualitative data were gathered from 27 provider informants—Rapid ART program staff and clinicians—using an interview guide developed using the CFIR. An experienced qualitative team conducted a comprehensive thematic analysis and identified cross-cutting themes in how providers approach and engage in the Rapid interaction, as well as longer-form narratives from providers that describe more fully what this interaction looks like for them.

Results
Three main themes represent the range and content of individual provider approaches to the Rapid interaction: (1) patient-centeredness; (2) emotional support and partnership; and (3) correcting misperceptions about HIV. Each theme encompassed both conceptual approaches to offering Rapid ART and concrete examples of messaging to the patient that providers used in the Rapid interaction. We describe and show examples of these themes, offer key take-aways for implementation, and provide expanded narratives of providers’ personal approaches to the Rapid interaction.

Conclusions
Exploration of provider-level approaches to Rapid ART implementation, as carried out in the patient-provider Rapid interaction, contributes a critical layer of evidence for wider implementation. It is our hope that, together with existing research showing positive outcomes and core components of systems-level implementation, these findings add to an instructive body of findings that facilitates the implementation of Rapid ART as an enhanced model of HIV care.