bluuebunny/crossref_metadata_2025_split huggingface dataset:
“Smart Cities”: Legal Regulation and Potential of Development
Authors: Tikhaleva E. Yu. 
Published: August 2023

Objective: to research the trends of development of the “smart cities” concept and their legal regulation.Methods: general scientific (induction, deduction) and special (systemicstructural, comparative-legal analysis) methods were used. Also, review analysis was applied to analyze the status quo of “smart cities”. Innovative research approaches are still rare in considering the “smart cities” concept, as well as the prospects referring to targeted knowledge management and cooperation between the respective stakeholders. As for the special research methods for studying digital relations, we used content analysis (the method of creating reproducible and substantiated conclusions from texts (or other meaningful materials) in the context of their use). As the results of previous research and concepts referring to “smart cities” are available, we also used deductive content analysis.Results: a characteristic is given to public relations formed within the process of development of “smart cities” concept. The key legal acts, principles of formation and functioning of “smart cities” are identified, taking into account the Russian and foreign experience. In this connection, the examples of successful practices are given, of the activities of both Russian and foreign municipal entities, taking into account the competitions held and rankings determined by the central structures. The popular directions are summarized, which are broadly introduced at the local level, and the probable problems are identified in the sphere of implementation of this project in our state.Scientific novelty: the article carries out an analysis of the current legal regulation and the results of introducing the “smart cities” concept. The promising technologies and methods are identified, which are necessary to achieve the tasks of the concept implementation. The elements are specified, which ensure sustainability of “smart cities” complying with the future demands. An author’s position is expressed regarding a close interrelation of this phenomenon with the institute of local self-government in the context of possible development of the latter into the process of making managerial decisions involving artificial intelligence. This concerns, first of all, using the potential of the Internet of Things. In practice, a lot of problems occur, associated with the implementation of normatively stipulated provisions, which implies the need to perform further research in the sphere under study.Practical significance: is due to the insufficient development of data about the features and prospects of introducing the idea of “smart cities”. The provisions of the research performed will allow effectively improving the mechanisms of legal regulation and broad implementation of the concept under study.
An efficient implementation of novel Polar encoder with Wavelet pipelining Architecture for 5G Networks
Authors: A Albert Raj , ebenezer vijila , A Calin , D Subbulekshmi 
Published: August 2023

Abstract
The polar code is one of the error correcting codes which was proposed by Dr. Arıkan It attracts the attention of researchers due to the capacity achieving algorithms over a wide range of channels. However polar codes sacrifices encoding complexity and latency to improve error performance. To address this issue, wave pipelining is proposed in this article. The main advantage of pipelining is parallelism which leads to the improvement in latency. In addition, the system gets the benefit of the increased computation rate, or throughput. The absence of registers at the intermediate stages in the wave pipeline makes the polar code more power efficient and efficient area overheads. It provides a method for significantly reducing clock by keeping the external functionality and timing of any circuit. This architecture is coded in VHDL language and the design is synthesized in SYNOPSYS tool and implemented in the Virtex-7 VC 709 FPGA device. The synthesis report proved that 50 % of efficiency in area and timing in the wave pipelining compared to the conventional methods.
Food Diversity, Children Health and the Economic Burden
Authors: Hasanah Alfiah , Kharisma Bayu , Remi Sutyastie S , Adam Asep Muhammad , Siregar Adiatma YM 
Published: August 2023

Abstract

Background This study investigate the impact of low food diversity on the health status of children using Dietary Diversity Score (DDS) and Dietary Serving Score (DSS) in a sub-district with the highest percentage of poor households. The economic burden of low food diversity is observed by analysing cost of illness of the children with low food diversity. Methods Data from 329 children are collected. We determined the impact of DDS and DSS and other factors to the health status of children age 2–14 yo using probit model. The cost of illness (e.g. typhus, stomach ulcers, coughs, flu, and fever) due to low food diversity is calculated from medical registration fees, medical action costs, transportation costs, and other costs. Results The results shows that a 1 percentage point increase of DDS or DSS potentially decreases children health complaints by 10 and 8 percent. Given the current 26 percent prevalence of health complaints among children with low DDS, the economic burden reaches US$75.72. On the other note, the current 41 percent prevalence of children with low DDS resulted in US$153.45 per children. Conclusions The effect of inadequate dietary diversity is potentially high on children health and contributes to economic burden for households and the government.
Associations of Two Psychotic Disorders with Constipation: A Mendelian Randomization Study
Authors: Liu Jiali , Huang Ye-bao , Chen Xiaopin , Qian Hai-hua , Zhang Dan 
Published: August 2023

Abstract
Background: Psychiatric disorders have been associated with Constipation in observational studies, although their causal relationships remain uncertain. We used Mendelian randomization analysis to infer causality between Psychiatric disorders and Constipation.
Methods: The exposure of interest was Psychiatric disorders(Schizophrenia(SCZ) and Major Depressive Disorder(MDD)). Summary statistics for psychiatric disorders were recruited from the PGC, SCZ (30,490 cases and 312,009 controls), MDD (170,756 cases and 329,443 controls), whereas Constipation summary genetic data were obtained from a FinnGen involving 17,246 cases and 201,546 controls. The inverse variance weighted (IVW) method was used as the primary analysis to assess the causal relationship between Psychiatric disorders and Constipation.
Results: LDSC indicated that Constipation are genetically correlated Psychiatric disorders (rg range: |0.04–0.05). The Mendelian randomization analysis indicated that there was significant evidence that genetically determined SCZ ( OR= 1.05, 95% CI =1.02 to 1.07, P＜0.01) and MDD( OR= 1.21, 95% CI =1.10 to 1.33, P＜0.01) were significantly causally associated with the risk of the Constipation.
Conclusion: The Mendelian randomization analysis suggested that SCZ and MDD increase the risk of Constipation.
Equivalent modulus of nanoporous materials based on Steigman-Ogden surface model
Authors: Zheng Chenyi , Li Gaohui , Zhang Mengjie , Jiang Yali , Wang Hongzhen , Li Zhengliang , Sun Mengcheng , Zheng Haolei 
Published: August 2023

Abstract
The work of this paper mainly includes two parts. The first part is to simplify the stress boundary equation of the complex Steigmann-Ogden surface model expressed by the surface gradient operator in spherical coordinates to the stress boundary equation expressed by the spatial gradient operator according to the surface projection tensor. This simplification can directly substitute the complex formula into the fingermark method and directly calculate it into the sizeable mathematical calculation software. In the second part, based on the Mori-Tanaka hole model, the displacement field is decoupled into a hydrostatic and partial displacement field. Based on the homogenization approach, the equivalent elastic modulus of nanoporous materials is solved by satisfying the displacement boundary equation on the boundary of the representative volume element (RVE). The hydrostatic displacement field corresponds to the macroscopic equivalent bulk modulus, while the offset displacement field corresponds to the macroscopic equivalent shear modulus. Finally, this paper conducted auspicious numerical experiments on various surface elastic parameters and explored their control mechanisms. The research in this paper can provide a theoretical basis for designing and manufacturing nanoporous materials.
Management of giant left atrial thrombus late after Transcatheter Mitral Valve-in-ring Replacement using a Transcatheter Aortic Valve
Authors: Maloku Aurel , Hamadanchi Ali , Bargenda Steffen , Richter Markus , Möbius-Winkler Sven , Schulze Christian , Franz Marcus 
Published: August 2023

Abstract

In symptomatic high-risk patients with severe mitral valve regurgitation (MR), who are not eligible for surgery due to multimorbidity, and further do not fulfill the criteria for a Transcatheter edge-to-edge repair procedure (TEER, e.g., using the MitraClip™ system), transcatheter mitral valve replacement (TMVR) may be considered (IIb C) according to current guidelines. Since patients with severe MR due to failing biological mitral valve prostheses are never eligible for TEER and patients after surgical mitral valve repair are sometimes not eligible for TEER, TMVR using transcatheter aortic valve prosthesis has been successfully performed in smaller patient cohorts using both, the transapical as well as the transvascular access route. Due to that limited experiences and outcome data, there is currently no guideline recommendation for these special situations.
Circular RNA CDR1as/ciRS-7-- A Novel Biomarker in Solid Tumors
Authors: Zhang Yun , Kang Zhiqiang , Zhao Tang , Zhang Qiu , Pu Feng , Xu Zihan , Zhao Xinhao , Fu Qiang , Yang Hongji , Wang Haizhen , Zhou Yu , Zhu Shikai 
Published: August 2023

Abstract
Background
Circular RNA CDR1as/ciRS-7 has been reported to function as an oncogenic regulator in various cancers. However, the prognostic value of CDR1as/ciRS-7 expression in solid tumors remains unclear. Herein, we conducted an updated meta-analysis to investigate the association between CDR1as/ciRS-7 expression and clinical outcomes in solid tumors.
Methods
A systematic search was performed through the PubMed, EMBASE, Web of Science, Ovid, Cochrane library, CNKI and WanFang databases for eligible studies on clinical values of CDR1as/ciRS-7 in solid tumors. The pooled hazard ratios (HRs) or odd ratios (ORs) with 95% confidence intervals (CIs) were used to evaluate the correlation between CDR1as/ciRS-7 and clinical outcomes.
Results
A total of 2342 patients from 16 studies between 2017 and 2023 were included. The results suggested that elevated CDR1as/ciRS-7 expression predicted a poor OS for 12 types of solid tumors (HR = 1.90, 95% CI: 1.40–2.59, P < 0.001) with no heterogeneity (I2 = 80.9%, P < 0.001). Stratified analysis indicated that there was a negative relationship between CDR1as/ciRS-7 expression and OS in digestive system cancers (HR = 2.28, 95% CI: 1.81–2.88, P < 0.001), and respiratory cancers (HR = 2.40, 95% CI: 1.75–3.30, P < 0.001). Furthermore, we also revealed that CDR1as/ciRS-7 was positively related to tumor size (OR = 2.11, 95%CI: 1.64–2.71, P < 0.001), TNM stage (OR = 2.05, 95%CI: 1.65–2.54, P < 0.001), lymph node metastasis (LNM) (OR = 1.74, 95%CI: 1.38–2.21, P < 0.001), and distant metastasis (OR = 2.79, 95%CI: 1.71–4.55, P < 0.001). Although the probable evidence of publication bias was found in the studies with OS, tumor size, TNM stage, and LNM, the trim and fill analysis confirmed the reliability of these results was not affected.
Conclusion
Elevated CDR1as/ciRS-7 expression was associated with larger tumor size, advanced TNM stage, worse LNM, distant metastasis, and shorter OS, suggesting that CDR1as/ciRS-7 may act as an independent prognostic biomarker in solid tumors.
Robust Bioprocess Design and Evaluation of Commercial Media for the Serial Expansion of Human Induced Pluripotent Stem Cell Aggregate Cultures in Vertical-Wheel Bioreactors
Authors: Borys Breanna S. , Dang Tiffany , Worden Hannah , Abraham Brett D. , Gysel Emilie J. , Malinovska Julia , Larijani Leila , Krawetz Roman , Revay Tamas , Argiropoulos Bob , Rancourt Derrick E. , Kallos Michael S. , Jung Sunghoon 
Published: August 2023

Abstract

Background: While pluripotent stem cell (PSC) therapies move toward clinical and commercial applications at a rapid rate, manufacturing reproducibility and robustness are notable bottlenecks in regulatory approval. Therapeutic applications of PSCs require large cell quantities to be generated under highly robust, well-defined, and economically viable conditions. Small-scale and short-term process optimization, however, is often performed in a linear fashion that does not account for time needed to verify the bioprocess protocols and analysis methods used. Design of a reproducible and robust bioprocess should be dynamic and include a continuous effort to understand how the process will respond over time and to different stresses before transitioning into large-scale production where stresses will be amplified.
Methods: This study utilizes a baseline protocol, developed for the short-term culture of PSC aggregates in Vertical-Wheel® bioreactors, to evaluate key process attributes through long-term (serial passage) suspension culture. This was done to access overall process robustness when performed with various commercially available media and cell lines. Process output variables including growth kinetics, aggregate morphology, harvest efficiency, genomic stability, and functional pluripotency were assessed through short and long-term culture.
Results: The robust nature of the expansion protocol was demonstrated over a six-day culture period where spherical aggregate formation and expansion were observed with high-fold expansions for all five commercial media tested. Profound differences in cell growth and quality were revealed only through long-term serial expansion and in-vessel dissociation operations. Some commercial media formulations tested demonstrated maintenance of cell growth rates, aggregate morphology, and high harvest recovery efficiencies through three bioreactor serial passages using multiple PSC lines. Exceptional bioprocess robustness was even demonstrated with sustained growth and quality maintenance over 10 serial bioreactor passages. However, some commercial media tested proved less equipped for serial passage cultures in bioreactors as cultures led to cell lysis during dissociation, reduction in growth rates, and a loss of aggregate morphology.
Conclusions: This study demonstrates the importance of systematic selection and testing of bioprocess input variables, with multiple bioprocess output variables through serial passages to create a truly reproducible and robust protocol for clinical and commercial PSC production using scalable bioreactor systems.
Unraveling the evolutionary origin of the complex Nuclear Receptor Element (cNRE), a cis-regulatory module required for preferential expression in the atrial chamber
Authors: Neto Jose Xavier , Santos Luana Nunes , Costa Angela Maria Sousa , Nikolov Martin , Carvalho João , Sampaio Allysson Coelho , Stockdale Frank , Castillo Hozana Andrade , Grizante Mariana Bortoletto , Dudczig Stefanie , Vasconcelos Michelle , Rosenthal Nadia , Jusuf Patricia , Nim Hieu , Lopes-de-Oliveira Paulo , Matos Tatiana Guimaraes de Freitas , Nikovits William , Schubert Michael , Ramialison Mirana 
Published: August 2023

Abstract
Optimal cardiac function requires appropriate contractile proteins in each heart chamber. Atria require slow myosins to act as variable reservoirs, while ventricles demand fast myosin for swift pumping functions. To achieve this functional distribution, myosins are thus under chamber-biased cis-regulatory control, with a failure in proper regulation of myosin genes leading to severe congenital heart dysfunction. However, the precise regulatory input leading to cardiac chamber-biased expression remains uncharted. To address this, we computationally and molecularly dissected the quail Slow Myosin Heavy Chain III (SMyHC III) promoter that drives preferential gene expression to the atria to define the regulatory information leading to chamber expression and understand its evolutionary origins. We show that SMyHC III gene states are autonomously orchestrated by a complex Nuclear Receptor Element (cNRE), a 32-bp DNA sequence with hexanucleotide binding repeats. Using in vivo transgenic assays in zebrafish and mouse models, we demonstrate that preferential atrial expression is achieved by a combinatorial regulatory input composed of atrial activation motifs and ventricular repression motifs. Using comparative genomics, we provide evidence that the cNRE might have emerged from an endogenous viral element, most likely through infection of an ancestral host germline. Our study hence reveals an evolutionary pathway to cardiac chamber-specific expression.
Factors Predicting Psychological Well-Being Among Survivors of Breast Cancer
Authors: Singtaweesuk Nuntana , Thanoi Wareerat , Vongsirimas Nopporn , Kesornsri Sirada , Klainin-Yobas Piyanee 
Published: August 2023

Abstract
Background
Breast cancer is the most common cancer diagnosed in women with health problems. Studies showed that breast cancer affects women’s mental health and lifestyle after receiving treatment. This study aimed to investigate four key factors (stress, social support, self-efficacy, mindfulness, and resilience) influencing psychological well-being among breast cancer survivors.
Methods
A predictive descriptive research design was conducted and guided by the resilience framework. Eligible criteria included breast cancer survivors receiving care at an outpatient clinic in a tertiary hospital. A convenience sampling was utilized and data were collected by self-administered questionnaires. Data analyses included univariate statistics and multiple linear regression.
Results
Totally, 123 participants were recruited. Stress, social support, and resilience explained 43% of the variance in psychological well-being among breast cancer survivors. Resilience (=.33), stress =-.27), and social support=.26) were significant predictors of psychological well-being and resilience was the strongest predictor.
Conclusions
Psychological factors related to post-disease wellness should be incorporated into interventions. Behaviors that promote resilience and social support and decrease stress levels should be incorporated into activities and programs to enhance breast cancer survivors’ psychological well-being in the future.
Characterization and Pathogenicity of Botryosphaeriaceae Species Associated with Trunk Canker, Gummosis and Dieback of Almond Trees in Turkey
Authors: endes ali , Keles Hakan , Güney Müjgan 
Published: August 2023

Abstract

Turkey is one of the leading almond countries in the world. Almond is a precious nut highly regarded in modern diets due to its bioactive compounds associated with health benefits and disease treatment. However, the yield of plant is affected by several factors, including pathogens. This study aimed to diagnose and identify biotic factors responsible for decline, dieback, and gummosis observed in almond trees in Yozgat province with a temperate climate. A thorough investigation was conducted in seven almond orchards and samples were collected from trees displaying aforementioned symptoms. The isolated species were cultured in PDA medium to identify the morphological and cultural characterization. The results obtained with cultural and morphological characteristics along with Phylogenetic analysis of ITS, β-tubulin, and EF-1α sequence data, confirmed the presence of Diplodia seriata, Lasiodiplodia theobromae, Neofusicoccum parvum, Botryosphaeria dothidea. Among these species, Botryosphaeria dothidea was first reported from almond trees in Turkey. Pathogenicity testing showed that although all species were virulent, L. theobromae and N. parvum isolates caused more gumming in the inoculation areas than D. seriata and B. dothidea isolates. These results confirmed that multiple species of Botryosphaeriaceae family are linked to branch decline and dieback on almond in Turkey, aligning with similar studies conducted on woody crops. Accurate diagnosis of fungal pathogens in almonds is vital for developing effective disease management strategies and may contribute to enhancing horticultural practices for the maintaince of urban almond stands.
Pulmonary Artery Sarcoma effecting the Pulmonary Valve diagnosed as pulmonary vasculitis: a case report and comparative literature review
Authors: Smith Harry James , Al-Zubaidi Fadi , Sitaranjan Daniel , Chiu Steven , Jenkins David 
Published: August 2023

Abstract
Pulmonary arterial sarcomas (PAS) are rare aggressive tumours occurring mainly in the pulmonary trunk. We report a case of pulmonary sarcoma incision involving the pulmonary trunk wall and valve, with uniform thickening which represents an atypical imaging manifestation of this tumour. A 63-year-old male presented with vague respiratory symptoms with rapid progression. CTPA showed low density filling defects in both pulmonary arteries and PET scan showed increased uptake in the pulmonary trunk, which along with raised ESR suggested Pulmonary Vasculitis. Echo imaging showed Right ventricular hypertrophy and pulmonary stenosis. Response to steroid therapy was minimal and his symptoms worsened. A referral for second opinion was made and he was diagnosed with Pulmonary artery sarcoma. He underwent Pulmonary thromboendarterectomy with Pulmonary valve replacement. Post-operative histopathology confirmed the diagnosis. PAS is rare and frequently misdiagnosed. Due to no formal management guidelines, we need to improve our understanding of PAS to improve treatment.
Factors associated with withholding of invasive mechanical ventilation in the early phase of the COVID-19 response and their ethical analyses
Authors: Morioka Shinichiro , Takashima Kyoko , Asai Yusuke , Suzuki Tetsuya , Nomoto Hidetoshi , Saito Sho , Suzuki Kumiko , Suzuki Setsuko , Sato Lubna , Nakamura Keiji , Nikaido Mio , Matsunaga Nobuaki , Hayakawa Kayoko , Mori Masanori , Yamamoto Keiichiro , Ohmagari Norio 
Published: August 2023

Abstract

Background
End-of-life decision making regarding invasive mechanical ventilation (IMV) for patients with severe coronavirus disease (COVID-19) is challenging. We aimed to explore the factors associated with the withholding of IMV in patients with COVID-19.
Methods
This retrospective study included patients registered in a nationwide COVID-19 Registry Japan. We enrolled patients with COVID-19 admitted between January 1, 2020, and June 30, 2021, and died during hospitalisation. The enrolled patients were divided into two groups: those who received IMV (IMV group) and those who did not (non-IMV group). To identify the factors associated with withholding of IMV among patients with COVID-19 who died during hospitalisation, we conducted a multivariate logistic regression analysis.
Results
A total of 2401 patients were enrolled. Of these, 588 (24.5%) were in the IMV group and 1813 (75.5%) in the non-IMV group. Withholding IMV was positively associated with older age (95% confidence interval [CI]: 0.82–0.88, p < 0.0001), dementia (95% CI: 0.81–0.91, p < 0.0001), chronic lung disease (95% CI: 0.88–1.00, p = 0.036), and malignancy (95% CI: 0.82–0.94, p < 0.0004) although inversely associated with male sex (95% CI: 1.04–1.15, p = 0.0008), body mass index (95% CI: 1.01–1.02, p < 0.0001), and National Early Warning Score (95% CI: 1.01–1.03, p < 0.0001).
Conclusions
We explored factors associated with the withholding of IMV and analysed the results to prepare for future emerging infectious disease pandemics by taking a retrospective look at the decision-making process during the COVID-19 disaster and considering multidisciplinary collaboration.