bluuebunny/crossref_metadata_2025_split huggingface dataset:
RELATIONSHIP BETWEEN CAROTID INTIMA MEDIA THICKNESS AND PHENOTYPES OF HIGH BLOOD PRESSURE IN ADOLESCENTS
Authors: Silva Egle , Bermudez Greily , Chacin Lisbeth , Bracho Mayela , Madueño Freddy 
Published: June 2023

Objective:
The aim of this study was to investigate the relationship between the Carotid Intima Media Thickness (cIMT) and high blood pressure phenotypes (HBPP) in a population of Hispanic adolescents.

Design and method:
It was conducted a cross-sectional study in Maracaibo, Venezuela that included 616 adolescents, 289 males and 327 females, selected from high school institutions (age: 13-18 years old). An ultrasonic study was carried out through high resolution B-mode ultrasound examinations for the measurement of the c-IMT. Also, 24-hs ambulatory blood pressure (ABPM) monitoring was performed to obtain ambulatory BP during 24-hs, awake and asleep periods. Demographic (age, gender), anthropometric data [weight, height, hip circumference, waist circumference (WC)] and office BP were recorded. The HBPP included were: true normotension (TN), sustained (SH), white coat (WCH) and masked (MH) hypertension according the new American Heart Association recommendations. Spearman Correlation was used to estimate the association between c-IMT and HBBPP.

Results:
The mean c-IMT value was 0.42 mm in all adolescents, 0.43 in males and 0.41 in females (p = 0.01). The HBPP prevalence in all adolescents was: 4. % (n = 26) for SH, 21.6 % (n = 133) for MH, 1.0 % (n = 6) for WCH and 73.2 % (n = 451) for TN. Males showed statistically significant high prevalence of MH and SH than female group [(28.4% vs. 15.6% for MH) and (8.3% vs. 0.6%) for SH. The adolescents with SH showed statistically significant higher values than those with TN in c-IMTI values [0.45±0.05 vs. 0.41.2±0.061 mm, p = 0.01]. There were statistically significant associations between c-IMT values with HBPP (Sperman rho = 0.115, p = 0.01).

Conclusions:
This study showed important associations between c-IMT values and HBPP in adolescents. Also, there is a very high prevalence of MH and SH; this condition appears to be associated with male gender. It should be important to evaluate c-IMT in those adolescents with office or ambulatory high BP values to investigate possible vascular changes induced by hypertension.
EFFECTS OF BLOOD PRESSURE ON THE HEALTH STATUS AMONG ADOLESCENTS 12-13 YEARS
Authors: Ospanova Ainur , Kerimkulova Aiman.S. , Rymbaeva Tamara.H. , Markabaeva Akbayan.M. , Nurpeissova Riza.G. , Idrissov Alisher.S. 
Published: June 2023

Objective:
To investigate the effects of blood pressure (BP) on health status, the appearance of complaints in adolescents

Design and method:
The results of a single-step cross-sectional study of teenagers aged 12-13 years studied in secondary schools in Semey city (Kazakhstan) are presented. The study included adolescents in the amount of 1519 (average age, standard deviation 12.3 + 0.46 years). For representing the outcomes there were used data from the conducted survey, the measurement of blood pressure of adolescents. Criteria for BP: normal BP (SBP and DBP <89 percentile); high normal BP (SBP and DBP < 90 and 94 percentile); arterial hypertension (SBP and DBP> 95 percentile). The criterion for the statistical significance of the obtained results was considered the value of p <0.05.

Results:
From studied teenagers, boys were 49.1% (n = 745), girls 50.9% (n = 774) respectively. Population with normal BP composed 62.7%, normal raised BP - 24.8%, hypertension -12.4%. Adolescents with normal blood pressure levels rated their health as poor 31, with elevated blood pressure 12 adolescents (p = 0.198). According to cardiovascular disease complaints, no statistically significant differences were found in adolescents (p = 0.66). Complaints with normal blood pressure - 198, with high blood pressure - 113.

Conclusions:
Most adolescents with hypertension complaints from the cardiovascular disease do not show and assess their health as good. That requires screening among adolescents
ASSOCIATION OF DEPRESSION AND ANXIETY WITH HYPERTENSIVE CRISIS. A CROSS SECTIONAL STUDY FROM A HOSPITAL SETTING IN KARACHI, PAKISTAN
Authors: Yousuf Fatimah Sireen , Arif Aiman , Bibi Raheela , Almas Aysha 
Published: June 2023

Objective:
Hypertension, a leading risk factor for cardiovascular death has been closely linked with depression and anxiety. The aim of this study was to examine the association of depression or anxiety with hypertensive crisis in patients from a hospital setting and also see if the association is affected by age groups or gender.

Design and method:
This cross-sectional study was conducted between July 2019 and March 2022 on 290 patients admitted at the Aga Khan University Hospital (AKUH). All adult patients of more than 18 years of age admitted with uncontrolled hypertension with systolic blood pressure of > 140 and diastolic blood pressure > 90 admitted through emergency were included. Hypertensive crisis was defined as systolic blood pressure more than 180mm Hg or a diastolic blood pressure more than or equal to 120mm Hg, with or without accompanying end organ damage. Depression and Anxiety were evaluated using the Hospital Anxiety and Depression Scale (HADS), with a cut-off score of greater than 8.

Results:
Of the patients identified with uncontrolled hypertension, a total of 140 (48.3 percent) of the patients presented with a hypertensive crisis, while 150 (51.3 percent) did not have a hypertensive crisis at presentation. In the hypertensive crisis group, 60 (49. percent) had HADS scores consistent with depression, while 83 (59.3 percent) had HADS scores consistent with anxiety. In patients with hypertensive crisis, HADS depression and anxiety were most prevalent in the 61-75 age group (39.7 percent). In the comparison of gender, it was found that males and females with hypertensive crisis had an almost equal prevalence of anxiety (49.4 percent in males versus 50.6 percent in females). A slightly higher prevalence of depression was seen in females with hypertensive crises when compared to males.

Conclusions:
We found no association between depression or anxiety with hypertensive crisis, and the association is not affected by age group or gender. However, do note that half of the patients with hypertensive crises had depression or anxiety. Future large multicentered studies are required to study the link in greater detail.
EFFECTS OF HYPERTENSION ON TAVI OUTCOMES
Authors: Sener Yusuf Ziya , Ates Ahmet Hakan , Sahiner Mehmet Levent , Kaya Ergun Baris , Aytemir Kudret 
Published: June 2023

Objective:
Severe aortic stenosis (AS) is the most common valvular disease in elderly and transcatheter aortic valve implantation (TAVI) is the standard of care treatment for AS in patients with high surgical risk. Hypertension accompanies with AS in this population in general. We aimed to evaluate the impact of hypertension on TAVI related outcomes.

Design and method:
All of the patients who underwent TAVI procedure between January 2010 and March 2020 were screened and patients with eligible datas were included. Datas were obtained from hospital electronic database.

Results:
A total of 306 cases were enrolled. Mean age of the population was 76.0 ± 10.4 61.4% of the cases were female. Median follow-up was 28.4 (13.0-49.5) months. Age was significantly higher (77.0 ±8.2 vs. 72.7± 14.8; p = 0.018) and diabetes was more frequent (37.6% vs. 16.9%; p = 0.001) in hypertensive patients. Use of RAS blockers (62.0% vs 28.6%; p<0.001) and calcium channel blockers (34.5% vs. 3.9%; p<0.001) were more frequent in hypertensive cases as expected. Baseline characteristics and outcomes were summarized in Table-1.
Left ventricular mass index was similar between the two groups (129.5 ± 32.8 vs. 132.7 ± 39.3; p = 0.502). Rates of contrast induced nephropathy, insertion site complications and need of de novo pacemaker implantation due to advanced heart block were not different between the two arms. Stroke rates were distinctly higher in patients with hypertension (7.4% vs 0%; p = 0.009), while all-cause mortality during follow-up was similar between patients with and without hypertension.

Conclusions:
Left ventricular mass index increases in patients with severe AS and hypertension also leads left ventricular hypertrophy by raising afterload. However, LVMI values were similar between patients with and without hypertension contrary to as expected. Higher proportion of RAS blocker use that has favorable effects on cardiac remodelling can explain this finding. Significantly increased risk of stroke in patients with hypertension is another attractive finding that should be kept in mind.
IMPACT OF DIABETES MELLITUS ON ARTERIAL STIFFNESS, AND PULSATILE HEMODYNAMICS IN HEART FAILURE WITH PRESERVED EJECTION FRACTION
Authors: Postadzhiyan Arman , Andreeva Lora , Tochev Sotir , Velchev Vassil , Finkov Bojidar 
Published: June 2023

Objective:
The aim of the current study was to characterize different parameters of arterial stiffness and pulsatile hemodynamics in patients with arterial hypertension and metabolic syndrome according the presence of diabetes mellitus and diastolic dysfunction.

Design and method:
121 consecutive patients with left ventricular ejection fraction > 40% were included in the study. LV diastolic function was assessed using pulsed wave Doppler on transthoracic echocardiography. Brachial-ankle pulse wave velocity (baPWV) and the cardio-ankle vascular index (CAVI) was measured using a VaSera VS-1500® device (Fukuda Denshi). Ambulatory BP monitoring over 24 hours was performed using the Mobilograph device (IEM, Stolberg, Germany) which measures brachial and central (aortic) BP, as well as time-resolved waveforms, allowing for ambulatory pulse wave analysis (including wave separation into forward and backward waves and reflection magnitude)

Results:
Among 121 patients included, diabetes mellitus was present in 55 (54.5%) and diastolic dysfunction in 54 (45.4%). The presence of impaired myocardial relaxation on echocardiography was associated with markedly increase of arterial stiffness parameters – CAVI (8.7 vs 8.1, p = 0.03), PWV (8.8 vs 7.9, p = 0.001), central hemodynamics - central SBP (129.4 vs 114 mmHg, p<0.001), cardiac output and total peripheral resistance (1.34 vs 1.25, p = 0.001) and pulsatile hemodynamics - with reduced reflection magnitude (60.7 vs 63, p = 0.04). Diabetic subjects with HFpEF exhibited a markedly greater left ventricular wall thickness and left atrium size on echocardiography. Pronounced aortic stiffening was also observed in the diabetic group (pulse wave velocity, 8.7 vs 7.9, p, 0.001; cardio-ankle vascular index, 9.1 vs 7.8, p<0.001), with an adverse pulsatile hemodynamic profile characterized by increased forward and backward wave amplitude and reduced reflection magnitude (61 vs 64.8, p = 0.05).

Conclusions:
The presence of diastolic dysfunction is associated with changes of arterial stiffness and pulsatile hemodynamics. Diabetes mellitus is a key determinant of left ventricular remodeling, arterial stiffness, adverse pulsatile hemodynamics, and ventricular-arterial interactions in HFpEF.
ERECTILE DYSFUNCTION IN HYPERTENSIVE PATIENTS: SCREENING AND MANAGEMENT BY GENERAL PRACTITIONERS IN FRANCE
Authors: Victor Latapie , Benedicte Giroux Leprieur , Cynthia Soare , Sabine Mercier , Rosaline Nguyen , Rashida Sariya , Robin Dhote , Marilucy Lopez-Sublet 
Published: June 2023

Objective:
Non-compliance remains one of the main factors of poor blood pressure control in France and worldwide. Erectile dysfunction (ED), a cardiovascular risk factor (CVRF), is common in hypertensive patients. The general practitioner (GP) is in the front line in the management of hypertension and is often the first point of contact in the event of ED.
To review the knowledge and practices of a sample of French GPs to promote the French Society of Hypertension (SFHTA) expert consensus on ED in hypertensive patients.

Design and method:
Descriptive observational study, carried out in a declarative mode via a Google Forms questionnaire distributed to 102 GPs practicing in Seine-St-Denis.

Results:
GPs (94,1 %) didn’t know the French Expert Consensus of the SFHTA, regardless their age or their mode of exercise. Only 10% of the GPs talked about ED with their patient regularly, whereas 68.6% of them declared to be comfortable discussing sexuality. GPs recognized ED as CVRF marker and were aware of possible side effects of the antihypertensive treatment on sexual function of their patient. However, the GPs were divided on the fact of warning the patients of the possible side effect of the treatments.

Conclusions:
Beyond the fact that the French Expert Consensus of the SFHTA concerning ED in hypertensive patients (2018) is not known in GPs, this work also highlights the difficulty of addressing the subject in consultation. Not prescribing beta-blockers in hypertensive patients (without any other indication) and identifying hypertensive patients with CVRF a fortiori with several drug classes are key elements for the best management of ED and combat non-compliance in hypertension.
INCREASED SERUM SCLEROSTIN LEVEL IS A RISK FACTOR FOR PERIPHERAL ARTERY OCCLUSIVE DISEASE IN PATIENTS WITH HYPERTENSION
Authors: Wang Hui-Sheng , Hsiao Chien-Hao , Wang Ji-Hung , Hsu Bang-Gee 
Published: June 2023

Objective:
Sclerostin is associated with endothelial inflammation and vascular calcification and therefore contributes to atherosclerosis disease. Hypertension is one of risk factors of peripheral arterial occlusive disease (PAOD), is associated with increased mortality in patients with hypertension. The aim of this study was to determine the relationship between serum sclerostin level and PAOD in patients with hypertension.

Design and method:
Fasting blood samples and baseline characteristics were obtained from 92 hypertensive patients. ABI values were measured using an automated oscillometric device. Patients with ABIs of <0.9 were categorized into the low ABI group. The serum sclerostin and dickkopf-1 (DKK1) concentrations were determined using commercially available enzyme-linked immunosorbent assays.

Results:
In total, 14 patients with hypertension (15.2%) were in the low ABI group. When compared to those in the normal ABI group, the low ABI group had high rates of diabetes mellitus (P = 0.044) as well as the high serum C-reactive protein levels (P = 0.001) and sclerostin levels (P < 0.001), but the serum DKK1 level did not find this association (P = 0.639). The multivariable logistic regression analysis revealed that serum levels of sclerostin (odds ratio [OR]: 1.052, 95% confidence interval [CI]: 1.018–1.088, P = 0.002) was independently associated with PAD in patients with hypertension.

Conclusions:
Serum levels of sclerostin, but not DKK1, were associated with PAOD in patients with hypertension.
MANAGING ANXIETY AND STRESS IN HYPERTENSION: DEVELOPMENT OF HEART RATE VARIABILITY BIOFEEDBACK WITH PSYCHOLOGICAL SUPPORT
Authors: Cross Ainslea 
Published: June 2023

Objective:
How can digital wearable Heart Rate Variability (HRV) biofeedback and psychological support be used to improve the management of anxiety and stress in hypertension?

Design and method:
A mixed methods study was used to develop and evaluate initial outcomes from a HRV biofeedback intervention for the management of anxiety and stress in hypertension.
We used systematic review evidence to guide a series of patient and stakeholder consultations to co-design a HRV biofeedback intervention to assess and treat anxiety and cardiovascular stress reactivity in a hypertension specialist outpatient's service. We evaluated initial outcomes from case studies of 15 patients who attended 2-5 x 1 hour face to face sessions with a Health Psychologist. Sessions involved: 1) assessment of anxiety and stress responses; 2) resonance frequency breathing training with HRV biofeedback with a respiration rate (between 6.5 and 4.5 breaths/minute) to produce optimal baroreflex stimulation and blood pressure regulation; 3) psychological skills development for dealing with anxiety and stress.

Results:
At 8 weeks follow up, 45% patients reported a 5-10 mmHg systolic reduction in blood pressure and 55% reported a reduction of 10-20 mmHg. 85% of patients reported increased morning HRV readiness scores and improvements in patient reported psychological outcomes (e.g. improvements in BP, anxiety reduction and increase in valued activities). 11 patients reported improved health behaviour change (increased physical activity, improved diet, reduction in alcohol intake). Whitecoat hypertension was improved in 70% of patients.

Conclusions:
Biofeedback with psychological support can help improve anxiety and stress symptoms, as well as improvements in systolic blood pressure within an integrated specialist hypertension team.
FEATURES OF COMORBIDITY IN COMBATANTS WITH ARTERIAL HYPERTENSION
Authors: Seliuk Olha , Voronko Andrii , Seliuk Mariana , Kozachok Mykola 
Published: June 2023

Objective:
Comprehensive assessment of comorbidity in patients with arterial hypertension of participants in modern armed conflicts in order to implement timely preventive measures with the aim of prolonging their health status for military service.

Design and method:
By design, the research was a passive retrospective one-time (cross-sectional) type. The medical charts of inpatient patients of 213 male combatants, aged 27-59 years, average age 45.0 ± 6.8 years, who underwent treatment during 2018-2021, were analyzed by the method of random sampling. The examined were stratified according to the stage of hypertension: 126 patients with stage I hypertension and 87 patients with stage II hypertension.

Results:
The value of the indicator of the complex assessment of comorbidity depending on the stage of hypertension (the overall assessment of comorbidity according to the CIRS cumulative scale of diseases was 7.1 ± 2.1 and 8.8 ± 2.9 points in patients with hypertension of the I and II stages, respectively, p < 0.05 .
The value of the indicators of the comprehensive assessment of comorbidity (the overall assessment of comorbidity according to the CIRS cumulative disease scale) in stage II hypertension is due to an increase in the number of causal diseases, which were 3.1 ± 0.8 in stage II hypertension and 2.2 ± 0.9 in stage I hypertension, p < 0.05.
No statistically significant differences were found in the number of diagnoses of competitive diseases: 4.1 ± 2.1 in stage II hypertension and 3.7 ± 1.7 in stage I hypertension, p > 0.05.

Conclusions:
With the progression of high blood pressure in military personnel who are participants in modern armed conflicts, suffering from high blood pressure, the number of concomitant diseases and the indicator of the comprehensive assessment of comorbidity (the overall assessment of comorbidity according to the CIRS cumulative disease scale) increase, which are caused by an increase in the number of causal diseases.
In order to extend the state of health for military personnel, patients with hypertension, participants of modern armed conflicts, measures for the secondary prevention of causal diseases are appropriate.
EPIDEMIOLOGICAL FEATURES OF COMORBID PATHOLOGY IN COMBATANTS WITH ARTERIAL HYPERTENSION
Authors: Seliuk Olha , Voronko Andrii , Seliuk Mariana , Kozachok Mykola 
Published: June 2023

Objective:
Determination of the prevalence of comorbid pathology in patients with arterial hypertension (AH) participants in modern armed conflicts in order to implement timely preventive measures in order to prolong their health for military service.

Design and method:
By design, the research was a passive retrospective one-time (cross-sectional) study. The medical charts of inpatient patients of 213 male combatants, aged 27-59 years, average age 45.0 ± 6.8 years, who underwent treatment during 2018-2021, were analyzed by the method of random sampling. The examined patients were stratified according to the stage of hypertension: 126 patients with hypertension stage I and 87 patients with hypertension stage II.

Results:
The most common comorbid diseases with hypertension in combatants were diseases of the circulatory system (DCS, 60%), diseases of the endocrine system, nutritional disorders and metabolic disorders (DES, 82%), diseases of the nervous system (DNS, 65%), musculoskeletal diseases ulcer system and connective tissue (59%), diseases of digestive organs (52%), anxiety and depressive disorders (85% and 97% of patients, respectively).
The association of an increase in the frequency of various concomitant diseases with the second stage of hypertension was determined - in stage II hypertension, compared with stage I hypertension, DCS was diagnosed more often (98% and 33%, respectively, p < 0.05), DEC (86% and 78%, respectively, p < 0.05), DNS (respectively 77% and 56%, p < 0.05). And diseases of the genitourinary system were more often diagnosed with stage I hypertension (43% and 22%, respectively, p < 0.05).
The higher frequency of diagnosis of DCS in stage II hypertension is caused by coronary heart disease (97% and 25%, respectively, p < 0.05).

Conclusions:
The most common comorbid diseases in military personnel with hypertension who are participants in modern armed conflicts are DCS, DES, DNS, diseases of the musculoskeletal system and connective tissue, diseases of the digestive organs, anxiety and depressive disorders.
In order to prolong the health for military personnel with hypertension and participants in modern armed conflicts, measures for the secondary prevention of DCS (primarily coronary heart disease), DES, DNS, anxiety and depressive disorders are expedient.