bluuebunny/crossref_metadata_2025_split huggingface dataset:
Convolutional neural network and 2D logistic-adjusted-Chebyshev-based zero-watermarking of color images
Authors: Darwish Mohamed M. , Farhat Amal A. , El-Gindy T. M. 
Published: September 2023

AbstractRobust zero-watermarking is a protection of copyright approach that is both effective and distortion-free, and it has grown into a core of research on the subject of digital watermarking. This paper proposes a revolutionary zero-watermarking approach for color images using convolutional neural networks (CNN) and a 2D logistic-adjusted Chebyshev map (2D-LACM). In this algorithm, we first extracted deep feature maps from an original color image using the pre-trained VGG19. These feature maps were then fused into a featured image, and the owner's watermark sequence was incorporated using an XOR operation. Finally, 2D-LACM encrypts the copyright watermark and scrambles the binary feature matrix to ensure security. The experimental results show that the proposed algorithm performs well in terms of imperceptibility and robustness. The BER values of the extracted watermarks were below 0.0044 and the NCC values were above 0.9929, while the average PSNR values of the attacked images were 33.1537 dB. Also, it is superior to other algorithms in terms of robustness to conventional image processing and geometric attacks.
Calculation of Fresnel integrals of real and complex arguments up to 28 significant digits
Authors: Zaghloul Mofreh R. , Alrawas Leen 
Published: September 2023

AbstractWe present numerical algorithms for efficient and highly accurate computations of Fresnel’s sine and cosine integrals S(z) and C(z) for real (z = x) and complex (z = x + iy) arguments. The algorithms are based on series expansion for small values of |z|, expansion in Chebyshev subinterval polynomial approximations for intermediate real values (y = 0), toggled with sum of half-integer order Bessel functions for complex arguments, together with asymptotic series expansion for large values of |z|. The present algorithms, implemented in a Fortran elemental module, can be run using any of the single, double, or quadruple precision arithmetic. Results from the present code have been benchmarked versus comprehensive data tables, generated using Maple, Mathematica, and Matlab symbolic toolbox. Compared to a maximum of 16 significant digits in the literature, the present algorithms can calculate S(x) and C(x) up to 28 significant digits in the range xϵ[0, 106] and S(z) and C(z) to the same accuracy in the domain where |S(z)| and |C(z)| each is less than the largest finite floating point number in the precision under consideration with $$\mid \mathit{\arg}\ z\mid <\frac{\pi }{2}$$

∣
arg

z
∣
<

π
2

or more specifically $$3\times {10}^{-4}<\left|\frac{y}{x}\right|<2\times {10}^3$$

3
×

10

-
4

<

y
x

<
2
×

10

3

for S(z) and $$4\times {10}^{-4}<\left|\frac{y}{x}\right|<2.2\times {10}^3$$

4
×

10

-
4

<

y
x

<
2.2
×

10

3

for C(z).
Syntax of European Union Law
Authors: Nowak-Far Artur 
Published: September 2023

AbstractThe article investigates the significance of syntax in the multilingual EU law. It attempts to respond to the question whether syntax is apt to contribute to the uniformity of that law and how, with regard to this function, it relates to the (widely disputed yet uncontested) semantic and pragmatic methods of achieving such a uniformity. In order to respond to this question, the article firstly, recalls fundamental concepts which would help conceptualize the endeavour and, secondly, presents examples of analysis of syntax arrangements which can be deemed representative for the study of the said problem of contribution. The study finds that EU law (expressed in 24 official languages which have equal authentic status) relies on diversified syntax of its respective constitutive languages. Syntax structures used in respective language versions of EU law represent narrower, law-specific, form of syntax structures available in these languages. Its specificity is determined mostly by legislative traditions of respective EU member states. Syntactic structures of EU law produced in different official languages do not represent a single pattern because of diversified mode of producing illocutionary value of provisions in which strongly idiomatic modal verbs (modal operators) and even special modal structures (not necessarily containing modal verbs) are used to express legal norms. They also differ when it comes to their law-specific compositionality, i.e. flexibility of different syntax structure to produce the same meaning and, in the same time, to preserve their genre/register informational value. Notwithstanding, these structures have well pronounced and system-significant common features within respective Germanic, Romanic, and Slavic families of languages in which EU law is mostly reproduced. The sentence structure and the relevant register of EU law provisions are the same for respective versions of EU texts of law expressed in the languages belonging to the respective three language families which were examined for the sake of this study. These common features are re-enforced by the synoptic mode of producing EU law which imposes formal resemblance of provisions reproduced in respective EU official languages to each other. The multilingual EU legislator also uses patterns which grant legal text the relevant register, yet its specific EU character ultimately transpires through semantic aspects of EU texts rather than their mere syntax. The unity of the system is achieved most strongly through the EU specific interpretation, where the teleological methods (which can be conceived as a language means to achieve EU law goals and objectives at the pragmatic level) are of utmost importance. Thus, there is no EU-specific syntax which would, as such, contribute to unity of EU law. Instead, unity is achieved in the area of semantics and pragmatics. The well exposed anaphoric character of EU law (as any other type of law) may contribute to narrowing down possibility for differentiation of respective language versions of EU law.
Short-Term Stock Performance of Health Care Companies in Times of Viral Epidemics and Pandemics
Authors: Alberti Eugen , Herberger Tim Alexander , Ender Manuela 
Published: September 2023

AbstractThe spread of Coronavirus Disease 2019 significantly influenced the global economy. Companies from the health care industry could emerge as potential winners in health crises, and their listed stocks could potentially outperform. For the first time in the English and German language literatures, this study investigates whether this occurred and which factors influenced the short-term stock price performance of companies from the health care industry during epidemics and pandemics. An event study of virus-related epidemics and pandemics from 2000 to 2020 was conducted. The results show that the stocks of companies from the health care industry tend to outperform the market during pandemics. The selection of the subindustry in the health care industry and the region of the stock markets significantly influenced abnormal returns. The results are especially relevant for investors seeking short-term trading opportunities but also provide implications for diversifying their portfolios during epidemics and pandemics.
Assessment of robotic telesurgery system among surgeons: a single-center study
Authors: Rudiman Reno , Mirbagheri Alireza , Candrawinata Valeska Siulinda 
Published: September 2023

AbstractThe field of robotic-assisted surgery is expanding rapidly; therefore, future robotic surgeons will need to be trained in an organized manner. Here, we aimed to examine surgeon performance on the Sinaflex Robotic Telesurgery System for correlation with training hours spent in training program. This is a prospective study of a single-center experience at the Hasan Sadikin Hospital, Bandung City of West Java, Indonesia. We included 43 surgeons from 11 departments, all invited to train using the Sinaflex Robotic Telesurgery system at the Hasan Sadikin Hospital. All study cohorts have never performed a robotic surgery procedure beforehand and have had at least five years of field experience. The surgeons were free to choose their training duration and simulation. After finishing the training session, they were asked to perform several tasks with increasing difficulty levels. There were nine training tasks in total with increasing levels of difficulty. A total of 43 surgeons from 11 different department were included in this prospective study. Our study was separated into 3 different batches and most surgeons failed to pass the examination (n = 12, 8, and 9, for batches 1, 2, and 3, respectively). The “failed” surgeon, additionally, tended to be older than the “passed” cohort (49.3 ± 7.4 vs 42.1 ± 7.3 years old, p = 0.005). In terms of duration of hours spent training on the robot, there was little difference training hours between the cohort that passed and the cohort that failed cohort (10.0 [8.4–10.1] vs 10.0 [8.0–10.0], respectively) with a p value of 0.265. We found no correlation between the total hours spent in the training program and surgeon performance on the Sinaflex robotic telesurgery system. Structured robot surgical training courses must be incorporated into the training programs.
Complementary Proof Nets for Classical Logic
Authors: Pulcini Gabriele , Varzi Achille C. 
Published: September 2023

AbstractA complementary system for a given logic is a proof system whose theorems are exactly the formulas that are not valid according to the logic in question. This article is a contribution to the complementary proof theory of classical propositional logic. In particular, we present a complementary proof-net system, $$\textsf{CPN}$$
CPN
, that is sound and complete with respect to the set of all classically invalid (one-side) sequents. We also show that cut elimination in $$\textsf{CPN}$$
CPN
enjoys strong normalization along with strong confluence (and, hence, uniqueness of normal forms).
Safety and Efficacy of DT-DEC01 Therapy in Duchenne Muscular Dystrophy Patients: A 12 - Month Follow-Up Study After Systemic Intraosseous Administration
Authors: Siemionow Maria , Biegański Grzegorz , Niezgoda Adam , Wachowiak Jacek , Czarnota Jarosław , Siemionow Krzysztof , Ziemiecka Anna , Sikorska Maria H. , Bożyk Katarzyna , Heydemann Ahlke 
Published: September 2023

AbstractDuchenne Muscular Dystrophy (DMD) is a progressive and fatal muscle-wasting disease with no known cure. We previously reported the preliminary safety and efficacy up to six months after the administration of DT-DEC01, a novel Dystrophin Expressing Chimeric (DEC) cell therapy created by fusion of myoblasts of DMD patient and the normal donor. In this 12-month follow-up study, we report on the safety and functional outcomes of three DMD patients after the systemic intraosseous administration of DT-DEC01. The safety of DT-DEC01 was confirmed by the absence of Adverse Events (AE) and Severe Adverse Events (SAE) up to 21 months after intraosseous DT-DEC01 administration. The lack of presence of anti-HLA antibodies and Donors Specific Antibodies (DSA) further confirmed DT-DEC01 therapy safety. Functional assessments in ambulatory patients revealed improvements in 6-Minute Walk Test (6MWT) and timed functions of North Star Ambulatory Assessment (NSAA). Additionally, improvements in PUL2.0 test and grip strength correlated with increased Motor Unit Potentials (MUP) duration recorded by Electromyography (EMG) in both ambulatory and non-ambulatory patients. DT-DEC01 systemic effect was confirmed by improved cardiac and pulmonary parameters and daily activity recordings. This follow-up study confirmed the safety and preliminary efficacy of DT-DEC01 therapy in DMD-affected patients up to 12 months after intraosseous administration. DT-DEC01 introduces a novel concept of personalized myoblast-based cellular therapy that is irrespective of the mutation type, does not require immunosuppression or the use of viral vectors, and carries no risk of off target mutations. This establishes DT-DEC01 as a promising and universally effective treatment option for all DMD patients.
Graphical Abstract
Hyaluronan-CD44 Interaction Regulates Mouse Retinal Progenitor Cells Migration, Proliferation and Neuronal Differentiation
Authors: Ma Jian , Fang Xiaoyun , Chen Min , Wang Yao , Zhang Li 
Published: September 2023

AbstractCell-based therapies have shown great potential because of their abilities to replace dying retinal neuron cells and preserve vision. The migration, proliferation and differentiation of retinal progenitor cells(RPCs) plays a vital role in the integration of the RPCs into the retina when transplanted into the host. Our study aimed to explore the effects of Hyaluronan(HA)-CD44 interactions on the regulation of RPCs migration, proliferation and differentiation, and investigate the underlying regulatory mechanisms. We found that CD44 was expressed in RPCs, and the HA-CD44 interaction markedly improved RPCs adhesion and migration. The stimulation of microRNA-21(miR-21) expression by the HA-CD44 interaction was protein kinase C (PKC)/Nanog-dependent in RPCs. Treatment of RPCs with PKC- or Nanog-specific ASODN or miR-21 antagomir effectively blocked HA-mediated RPCs adhesion and migration. Moreover, Rho-Kinase(ROK)/ Grb2-associated binders(Gab-1) associated phosphatidylinositol 3-kinase(PI3K)/AKT signalling activation was required for HA-CD44 interaction mediated RPCs proliferation and neuronal differentiation. Our findings demonstrated new roles for the HA-CD44 interaction in regulating the migration, proliferation and neuronal differentiation of RPCs. HA-CD44 signalling could represent a novel approach to controlling RPC fates, and the findings may be instructive for the application of RPCs for future therapeutic applications.
Graphical Abstract
Identification of galactosamine-(N-acetyl)-6-sulfatase (GALNS) as a novel therapeutic target in progression of nasopharyngeal carcinoma
Authors: Zhang Jin , Ran Hong , Wang Zhen , Liu Peng , Kang Chenglin , Zeng Xianhai , Qiu Shuqi , Zhang Peng 
Published: September 2023

AbstractNasopharyngeal carcinoma (NPC) is a commonly diagnosed malignancy in southern China and southeast Asia. Previous studies have identified galactosamine-(N-acetyl)-6-sulfatase (GALNS) as a potential biomarker for multiple cancers. However, it is unknown whether GALNS plays a role in NPC development, and the underlying mechanisms remain unclear. In this study, we found that GALNS is overexpressed in NPC cell lines and tissues compared to the normal nasopharyngeal counterparts. Knocking down GALNS expression in the NPC cells significantly decreased their proliferation in vitro, and inhibited xenograft growth in a mouse model. Mechanistically, the anti-proliferative effect of GALNS silencing was the result of autophagy induction via the inhibition of PI3K–AKT–mTOR signaling pathway. Taken together, GALNS drives the progression of NPC via PI3K–AKT–mTOR signaling-mediated autophagy, and is therefore a promising therapeutic target.
Albinism in the common shrew Sorex araneus
Authors: Wójcik Jan M. , Kowalczyk Rafał , Rybiałek Jerzy , Herman Jeremy 
Published: September 2023

AbstractAlbinism is a hypopigmentation disorder which occurs as a consequence of mutations in genes involved in melanin biosynthesis. It is recorded in many mammalian species but is generally considered to be rare in natural populations. Here, we describe a fully albino individual of the common shrew Sorex araneus found in south-western Poland. We also present previous findings of albino specimens of this species in Europe. Since the 1960s, there have only been three confirmed records of wholly albino individuals of common shrews in mainland Europe; however, albinism has been recorded more frequently in this species from Britain. In other shrew species, wholly albino individuals are also recorded very rarely.
Satellite Manoeuvre Detection with Multistatic Radar
Authors: da Graça Marto Simão , Díaz Riofrío Sebastián , Ilioudis Christos , Clemente Carmine , Vasile Massimiliano 
Published: September 2023

AbstractTraditional radar sensors used for surveillance rely on monostatic radar principles. However, recently the use of remote radio frequency telescopes as bistatic receivers represents an interesting way to reuse existing facilities while providing additional information to improve tracking accuracy. In this paper we study the benefits of using such a system for the task of manoeuvre detection in satellites in LEO and MEO. We investigate the conditions in which a multistatic radar is advantageous for this purpose, and show concrete results based on simulated data. Moreover, we propose novel manoeuvre detection methods, and compare their accuracy to methods found in the literature. A more general way of assessing the accuracy of these manoeuvre detection methods is also proposed, with the aim of taking into account that the parameters of the manoeuvre that actually takes place also have an effect on the accuracy. These can be split into optimal control based methods, and statistical methods. We found the addition of multistatic radar to allow considerable improvement in the accuracy of the manoeuvre detection process, an improvement that is shown to be greater the greater the baseline, i.e., the distance of the receiver to the transmitter. Furthermore, the manoeuvre detection methods that accurately model the uncertainty in the measurements were found to be the most accurate.
Verhinderte Öffentlichkeit und dunkle Machenschaften
Authors: Jäger Nadine 
Published: September 2023

ZusammenfassungUnter den disparaten Deutungsansätzen, die für Kaufringers Märe Die Unschuldige Mörderin vorgeschlagen wurden, hat sich bislang die Lesart des Textes als Verhandlung juristischer Grundüberlegungen durchgesetzt. Der vorliegende Beitrag schlägt vor, den Text stattdessen aus einer anderen Perspektive zu beleuchten, die die soziale Dimension des Erzählten fokussiert: Kaufringers Unschuldige Mörderin setzt die Frage nach responsiblem Handeln im Gefüge sozialer Abhängigkeiten narrativ um. Ausgehend von der ›Versuchsanordnung‹ eines sozialen Verstoßes, der eine öffentliche Verhandlung a priori ausschließt, tritt die Dysfunktionalität privater, (hierarchisch-)sozialer Verbindlichkeiten und Heteronomien hervor. Die Protagonistin sieht sich Figuren gegenüber, die sich eigenmächtig aus dem Netz gegenseitiger Verantwortung lösen und, getrieben vom Streben nach sozialer Superiorität, zu ihren Opponenten avancieren. Die Schieflage hierarchischen Opportunismus’ und feudalen Ausgeliefertseins findet in der Handlung eine mehrfach variierende Umsetzung, während Pro- und Epimythion dagegen in Form eines Korrektivs anarbeiten. Dort wird eine Welt vollkommener, mutualer Absicherung und trewe entworfen und das kontingente Geschehen göttlicher Verantwortung zugeschrieben sowie sinnhaft aufgeladen.
To Seek Program Accreditation, Innovation, or Both?—Examining the Interdependencies in High-Reliability Health Care Organizations
Authors: Brand Tim , Goetjes Eva , Blankart Katharina 
Published: September 2023

AbstractIn dynamic markets, organizations have to be ambidextrous to adapt to constant change. Simultaneously, organizations are increasingly required to adopt quality management accreditation. Standardization through accreditation bares the risk of limiting an organization’s dynamic capabilities. In this study, we aim to evaluate the determinants of organizational decision-making to seek accreditation and pursue innovation activities, whether accreditation and innovation activities help organizations reach their strategic goals, and if accreditation affects the ability to achieve ambidexterity. We explore these relationships in high-reliability health care organizations. We conducted semi-structured interviews with 11 physicians and 14 quality managers in hospitals that provide specialized cancer care in Germany. In an inductive grounded theory approach, we develop a conceptual model of the relationship between accreditation and innovation activities. We find that hospitals engaged in both activities to achieve quality and financial goals. For smaller hospitals, accreditation was a necessary condition to be able to compete in market environments. Regardless of competition, smaller hospitals benefitted from a positive effect of accreditation on incremental process and product innovation. For larger hospitals, obtaining accreditation was a necessary condition to acquire additional funding, but the influence on innovation activities was limited because these were already being pursued with high intensity. Ideally, program accreditation and innovation activities can be aligned to achieve superior quality and financial performance through organizational ambidexterity. Organizational decision-makers must align both activities while taking account of costs and benefits. Policy makers can support access to high quality care by setting incentives to acquire accreditation.
Accelerated fracture healing by osteogenic Ti45Nb implants through the PI3K–Akt signaling pathway
Authors: Tan Jia , Li Jiaxin , Ran Zhaoyang , Wu Junxiang , Luo Dinghao , Cao Bojun , Deng Liang , Li Xiaoping , Jiang Wenbo , Xie Kai , Wang Lei , Hao Yongqiang 
Published: September 2023

AbstractThe key to managing fracture is to achieve stable internal fixation, and currently, biologically and mechanically appropriate internal fixation devices are urgently needed. With excellent biocompatibility and corrosion resistance, titanium–niobium alloys have the potential to become a new generation of internal fixation materials for fractures. However, the role and mechanism of titanium–niobium alloys on promoting fracture healing are still undefined. Therefore, in this study, we systematically evaluated the bone-enabling properties of Ti45Nb via in vivo and in vitro experiments. In vitro, we found that Ti45Nb has an excellent ability to promote MC3T3-E1 cell adhesion and proliferation without obvious cytotoxicity. Alkaline phosphatase (ALP) activity and alizarin red staining and semiquantitative analysis showed that Ti45Nb enhanced the osteogenic differentiation of MC3T3-E1 cells compared to the Ti6Al4V control. In the polymerase chain reaction experiment, the expression of osteogenic genes in the Ti45Nb group, such as ALP, osteopontin (OPN), osteocalcin (OCN), type 1 collagen (Col-1) and runt-related transcription factor-2 (Runx2), was significantly higher than that in the control group. Meanwhile, in the western blot experiment, the expression of osteogenic-related proteins in the Ti45Nb group was significantly increased, and the expression of PI3K–Akt-related proteins was also higher, which indicated that Ti45Nb might promote fracture healing by activating the PI3K–Akt signaling pathway. In vivo, we found that Ti45Nb implants accelerated fracture healing compared to Ti6Al4V, and the biosafety of Ti45Nb was confirmed by histological evaluation. Furthermore, immunohistochemical staining confirmed that Ti45Nb may promote osteogenesis by upregulating the PI3K/Akt signaling pathway. Our study demonstrated that Ti45Nb exerts an excellent ability to promote fracture healing as well as enhance osteoblast differentiation by activating the PI3K/Akt signaling pathway, and its good biosafety has been confirmed, which indicates its clinical translation potential.
Graphic abstract