bluuebunny/crossref_metadata_2025_split huggingface dataset:
Explaining Policy Failure in China
Authors: Yasuda John Kojiro 
Published: June 2023

AbstractWhy do policy experimentation regimes breakdown? And, if there are recognizable patterns of experimental failure, what might explain the variation? Focusing on aviation, finance and food safety, this article considers why a policy style that has been credited with China's successes in the past is failing to address governance challenges in these sectors at present. The article moves beyond discussions of policy mis-implementation by reframing experimental failure as a case of policy maladaptation under conditions of complexity and ambiguity. Maladaptation describes how approaches used in previous periods to foster adaptation can inadvertently make a system less resilient in the future. The analysis shows how the degree of consolidation of previously successful experimental regimes lends itself to certain types of maladaptation in the present: consolidated regimes are unable to generate policy alternatives (aviation), moderately consolidated regimes are maladapted for selection (finance), and unconsolidated regimes impede niche creation (food safety).
The association between the food environment and adherence to healthy diet quality: the Maastricht Study
Authors: Chan Jeffrey Alexander , Koster Annemarie , Eussen Simone JPM , Pinho Maria Gabriela M , Lakerveld Jeroen , Stehouwer Coen DA , Dagnelie Pieter C , van der Kallen Carla J , van Greevenbroek Marleen MJ , Wesselius Anke , Bosma Hans 
Published: June 2023

AbstractObjective:The purpose of this study is to determine if healthier neighbourhood food environments are associated with healthier diet quality.Design:This was a cross-sectional study using linear regression models to analyse data from the Maastricht Study. Diet quality was assessed using data collected with a FFQ to calculate the Dutch Healthy Diet (DHD). A buffer zone encompassing a 1000 m radius was created around each participant home address. The Food Environment Healthiness Index (FEHI) was calculated using a Kernel density analysis within the buffers of available food outlets. The association between the FEHI and the DHD score was analysed and adjusted for socio-economic variables.Setting:The region of Maastricht including the surrounding food retailers in the Netherlands.Participants:7367 subjects aged 40–75 years in the south of the Netherlands.Results:No relationship was identified between either the FEHI (B = 0·62; 95 % CI = –2·54, 3·78) or individual food outlets, such as fast food (B = –0·07; 95 % CI = –0·20, 0·07) and diet quality. Similar null findings using the FEHI were identified at the 500 m (B = 0·95; 95 % CI = –0·85, 2·75) and 1500 m (B = 1·57; 95 % CI = –3·30, 6·44) buffer. There was also no association between the food environment and individual items of the DHD including fruits, vegetables and sugar-sweetened beverages.Conclusion:The food environment in the Maastricht area appeared marginally unhealthy, but the differences in the food environment were not related to the quality of food that participants reported as intake.
Quantitative botanical characterization of Saragolla wheat landraces from Abruzzo and Puglia Regions of Italy
Authors: Rascio Agata , Fiorillo Fabrizio , Paone Silvana , De Santis Giuditta , Sorrentino Giuseppe 
Published: June 2023

AbstractSince the 1600s, a pasta wheat locally known as Sargolla, Saragollio or Saragollo has been cultivated in central and southern regions of Italy, including Abruzzo and Puglia. To identify if distinctive Saragolla landraces are present in Abruzzo and with a view to registering them as Conservation Varieties in the Abruzzo Regional Register of Genetic Resources, a quantitative botanical characterization of 11 farm-saved seed samples from Abruzzo and a previously defined Saragolla landrace from Puglia was performed. All twelve samples were grown for two years at the CREA-CI field station in Foggia, Puglia (Italy), and were morphologically characterized according to the criteria used by the botanist Johan Percival in 1921. In the 12 samples, we identified 9 taxonomically different botanical types, the most frequent of which were the italicum (32%), found in every population from Abruzzo. The leucurum and the affine were the main components of the previously defined Saragolla from Puglia. Results of the multivariate analysis indicated that the samples collected from farms in Abruzzo are more similar to each other than to the landrace of Saragolla from Puglia and support the registration of a specific Saragolla landrace for the Abruzzo region. The diachronic comparison of the botanical diversity of the currently cultivated Saragolla, with that observed in Sicily and Algeria at the beginning of 1900, suggests that a high degree of genetic diversity still exists in the 11 Saragolla populations from the Abruzzo Region.
Constrained river, constrained choices: seasonal floods and colonial authority in the Red River Delta
Authors: Ross Corey 
Published: June 2023

AbstractThis article examines the problem of flooding in colonial Tonkin through two interrelated lenses: the history of disasters as social and political phenomena, and the history of technology and the constraints that shape its use. With a gradient ten times steeper than the Mekong, the Red River (Sông Cáiin Vietnamese) is notorious for its huge seasonal fluctuations and violent floods. For centuries, local rulers and cultivators constructed dikes to protect fields and settlements, though breaches and inundations were frequent. French administrators were convinced that they could improve the flooding situation with modern know-how. From the 1890s, colonial engineers carefully studied the river's behavior, examined a range of different schemes to control it, and debated the extent to which the straitjacketing of the river might gradually exacerbate flood risk. Despite their deep-seated misgivings about the problems caused by dikes, they were ultimately forced to work within the parameters of pre-colonial hydraulic works. The result was an intensification of existing dependencies and flood vulnerabilities, which finally came to a head under the combined pressures of extreme weather and war, and which ultimately played an important role in undermining colonial authority in the Red River delta.
Results of a qualitative study of patient, carer and clinician views on the experience of caring for individuals with psychosis in Pakistan
Authors: Rathod Shanaya , Javed Afzal , Iqbal Rehmina , Al-Sudani Ayaat , Vaswani-Bye Akansha , Haider Imran , Phiri Peter 
Published: June 2023

Abstract
Cultural relevance is a core element of effective psychological interventions like cognitive behaviour therapy (CBT) or family intervention (FI), which can be considered Eurocentric. There have been few studies that have examined explanatory models of mental illness and its management in Pakistan to date. This study elicited patient- and carer-related health beliefs on psychosis including attributions to illness, and help-seeking behaviours to inform development of culturally sensitive treatment and improve outcomes in a unit in Lahore (Pakistan). The study group completed 45 semi-structured qualitative interviews at a mental health rehabilitation centre in Lahore. Data were analysed thematically using emerging themes and content analysis. Participants’ explanatory models for psychosis included religion or faith-driven beliefs, like previous wrong-doing and supernatural ideas such as black magic. Social factors that impacted families included high expectations, social stigma, and discriminations. Families first sought help from faith leaders and then medical or psychological sources of care. Participants had generally positive attitudes about their experience of psychological interventions.

Key learning aims

(1)
The need to consider cultural influences to ensure relevance of interventions like cognitive behaviour therapy (CBT) or family interventions (FI) in different countries.

(2)
The need for cultural adaptation of interventions like CBT and FI in different countries to make them accessible and acceptable.

(3)
When adapting therapy to a particular culture or country, recognizing the importance of engaging the local cultural population in the adaptation process.
Glacial Southern Ocean Expansion Recorded in Foraminifera‐Bound Nitrogen Isotopes From the Agulhas Plateau During the Mid‐Pleistocene Transition
Authors: Marcks B. A. , Dos Santos T. P. , Lessa D. V. O. , Cartagena‐Sierra A. , Berke M. A. , Starr A. , Hall I. R. , Kelly R. P. , Robinson R. S. 
Published: June 2023

AbstractThe emergence of 100‐Kyr glacial cycles (The Mid‐Pleistocene Transition [MPT]) is attributed in part to slower global overturning circulation and iron stimulation of biological carbon drawdown in the Southern Ocean. We present foraminifera‐bound nitrogen isotope values and polar planktic foraminifera abundances from the Agulhas Plateau that show that increases in biogenic sediment accumulation coincide with northward migrations of the Subtropical Frontal Zone (STFZ) and elevated foraminifera‐bound nitrogen isotope values during MPT glacial episodes. The nitrogen isotope values of two planktic foraminifera species, Globigerina bulloides and Globorotalia inflata show remarkable coherence amongst the sea surface temperature gradient between the STFZ and SAZ, and polar foraminifera abundances, indicating a strong relationship between nitrogen isotope dynamics above the Agulhas Plateau and migrations of the STFZ. Northward migration of the STFZ may have been essential to prolonging glacial intervals by increasing deep ocean carbon storage via a northward shift of the South Westerly Winds and a reduction in upwelling, delivery of fresher surface waters into the upper limb of global overturning circulation, or inhibiting heat and salt delivery to the Atlantic as Agulhas Leakage.
Reflections and Thoughts on the Future of Science From AGU Hydrology Section Fellows
Authors: Tyler Scott W. , Kent Jennifer , Anderson Suzanne P. , Brooks Paul D. , Packman Aaron I. , Uijlenhoet Remko , Western Andrew W. , Zeng Xubin 
Published: June 2023

AbstractAt the inaugural Frontiers in Hydrology Meeting in San Juan, Puerto Rico in the summer of 2022, the Hydrology Section organized a poster session and invited our 2020 and 2021 Classes of AGU Fellows, with the initial goal of both celebrating their careers as well as to provide an opportunity for an informal exchange and connection between the section's early career members and our more senior and established scientists and engineers. Due to the challenges of time zones, virtual poster presentations and other logistics, the formal poster session was adjourned but continued as a hybrid “meet‐up” with six of our Section's Fellows (Suzanne Anderson, Paul Brooks, Aaron Packman, Remko Uijlenhoet, Andrew Western, and Xubin Zeng) from around the world. As you will see, what started as an informal chat quickly took deep dives into pressing issues in our section and science in general, including thoughts on how our community values (or in some cases doesn't value) multi‐ and interdisciplinary accomplishments, critiques of our system of rewards and awards including how we assess publication impacts and finally, a frank and honest discussion of our current efforts to diversify our community and where/why are we still failing. We hope that by sharing this open and impromptu dialogue that these discussions can expand to our entire community, and to encourage future Fellows exchanges such as this to reach our entire community of scientists and engineers.
Modeling the Complete Nitrogen and Oxygen Isotopic Imprint of Nitrate Photolysis in Snow
Authors: Shi Guitao , Buffen Aron M. , Hu Ye , Chai Jiajue , Li Yilan , Wang Danghe , Hastings Meredith G. 
Published: June 2023

AbstractSnow nitrate is vulnerable to photolytic loss that causes isotopic alteration, and thus its isotopes can potentially track the extent of snow nitrate photolysis and its impacts in environments where loss is significant. Large increases in δ15N‐NO3− below the snow surface have been attributed to photolysis and this behavior is generally consistent amongst theoretical as well as lab and field studies. Oxygen isotope ratios are thought to be influenced by photolysis as well as secondary condensed‐phase chemistry, but the competing effects have yet to be reconciled. Here we use a model that simulates nitrate burial, photolytic fractionation, and re‐oxidation in snow to quantitatively assess these processes with the aim of developing a consistent framework for interpreting the photolytic effects of the complete nitrate isotopic composition (δ15N, δ18O, and Δ17O). This study reveals that isotopic effects of nitrate photolysis and aqueous‐phase re‐oxidation chemistry are important sources of uncertainties in modeling δ18O‐NO3−.
FBXO7, a tumor suppressor in endometrial carcinoma, suppresses INF2-associated mitochondrial division
Authors: Zhang Hui , Zhao Yiting , Wang Jie , Li Jinyun , Xia Jingyi , Lin Yan , Zhong Yeling , Cao Xinyi , Jin Jiabei , Li Xinming , Yang Weili , Ye Meng , Jin Xiaofeng 
Published: June 2023

AbstractEndometrial carcinoma (ECa) is the most common malignant gynecological cancer, with an increased incidence and fatality rate worldwide, while the pathogenesis is still largely unknown. In this study, we confirmed that FBXO7, a gene coding FBXO7 E3 ubiquitin ligase, is significantly downregulated and mutated (5.87%; 31/528) in ECa specimens, and the abnormal low expression and mutations of FBXO7 are associated with the occurrence of ECa. We also identify the excessive expression of INF2 protein, a key factor that triggers mitochondrial division by recruiting the DRP1 protein, and the elevated INF2 protein is significantly negatively correlated with the low FBXO7 protein in ECa specimens. Mechanistically, FBXO7 restrains ECa through inhibiting INF2-associated mitochondrial division via FBXO7-mediated ubiquitination and degradation of INF2. Moreover, we found that ECa-associated FBXO7 mutants are defective in the ubiquitination and degradation of INF2, promoting ECa cells proliferation, migration and apoptosis inhibition via inducing mitochondrial hyper-division. In addition, we found that it could reverse FBXO7 deletion or ECa-associated FBXO7 mutants-induced proliferation, migration, apoptosis inhibition and mitochondrial hyper-division of ECa cells by INF2 or DNM1L knockdown, or DRP1 inhibitor Mdivi-1. In summary, our study shows that FBXO7 acts as a novel tumor suppressor in ECa by inhibiting INF2-DRP1 axis-associated mitochondrial division through the ubiquitination and degradation of INF2 while the effect is destroyed by ECa-associated FBXO7 and INF2 mutants, highlights the key role of FBXO7-INF2-DRP1 axis in ECa tumorigenesis and provides a new viewpoint to treat ECa patients with FBXO7 deletion or mutations by targeting INF2-DRP1 axis-associated mitochondrial division.
The dual role of ferroptosis in anthracycline-based chemotherapy includes reducing resistance and increasing toxicity
Authors: Zhao Jiazheng , Zhang Ning , Ma Xiaowei , Li Ming , Feng Helin 
Published: June 2023

AbstractIn conjunction with previous studies, we have noted that ferroptosis, as an emerging mode of regulated cell death (RCD), is intimately related to anthracycline pharmacotherapy. Not only does ferroptosis significantly modulate tumour resistance and drug toxicity, which are core links of the relevant chemotherapeutic process, but it also appears to play a conflicting role that has yet to be appreciated. By targeting the dual role of ferroptosis in anthracycline-based chemotherapy, this review aims to focus on the latest findings at this stage, identify the potential associations and provide novel perspectives for subsequent research directions and therapeutic strategies.
A survey of genetic and palliative care health professionals’ views of integrating genetics into palliative care
Authors: White Stephanie , Turbitt Erin , Rogers Kris , Tucker Kathy , McEwen Alison , Best Megan , Phillips Jane L. , Jacobs Chris 
Published: June 2023

AbstractGenetic counselling and testing have utility for people with palliative care needs and their families. However, genetic and palliative care health professionals have described difficulties initiating palliative-genetic discussions. Between March and July 2022, we received n = 73 surveys (6% response rate) from genetic and palliative care health professionals in Australia and New Zealand that assessed and compared barriers and facilitators. The main perceived barrier to both groups was palliative care health professionals’ lack of genetic knowledge (44%). Most palliative care health professionals were ‘not at all confident’ performing several activities, including discussing DNA banking (52%) and knowing their legal responsibilities when sharing genetic information (58%). The most frequently selected facilitator for genetic health professionals was fostering close relationships with palliative care health professionals (52%), while palliative care health professionals indicated a genetic referral template (51%) would be of assistance. Almost all participants agreed genetic discussions do not undermine the central ethos of palliative care (87%). Fewer palliative care health professionals considered themselves well situated to have genetic discussions with a palliative patient’s family compared to genetic health professionals (p = 0.014). Our results suggest that genetic and palliative care health professionals support integrating genetics into palliative care, although refinement of the palliative care health professionals’ role in this process is required. We have identified intervention targets to overcome barriers related to knowledge and confidence, which ought to be integrated into future interventions designed to support health professionals deliver the benefits of genetic information to people with palliative care needs and their families.
Range-separated hybrid functionals for accurate prediction of band gaps of extended systems
Authors: Yang Jing , Falletta Stefano , Pasquarello Alfredo 
Published: June 2023

AbstractIn this work, we systematically evaluate the accuracy in band gap prediction of range-separated hybrid functionals on a large set of semiconducting and insulating materials and carry out comparisons with the performance of their global counterparts. We observe that all the range-separated hybrid functionals that correctly describe the long-range dielectric screening significantly improve upon standard hybrid functionals such as PBE0 and HSE06. The choice of the short-range Fock exchange fraction and the screening length can further reduce the predicted error. We then propose a universal expression for the selection of the inverse screening parameter as a function of the short-range and long-range Fock exchange fractions, which results in a mean absolute error as small as 0.15 eV for band gap prediction.
Microbial applications for sustainable space exploration beyond low Earth orbit
Authors: Koehle Allison P. , Brumwell Stephanie L. , Seto Emily P. , Lynch Anne M. , Urbaniak Camilla 
Published: June 2023

AbstractWith the construction of the International Space Station, humans have been continuously living and working in space for 22 years. Microbial studies in space and other extreme environments on Earth have shown the ability for bacteria and fungi to adapt and change compared to “normal” conditions. Some of these changes, like biofilm formation, can impact astronaut health and spacecraft integrity in a negative way, while others, such as a propensity for plastic degradation, can promote self-sufficiency and sustainability in space. With the next era of space exploration upon us, which will see crewed missions to the Moon and Mars in the next 10 years, incorporating microbiology research into planning, decision-making, and mission design will be paramount to ensuring success of these long-duration missions. These can include astronaut microbiome studies to protect against infections, immune system dysfunction and bone deterioration, or biological in situ resource utilization (bISRU) studies that incorporate microbes to act as radiation shields, create electricity and establish robust plant habitats for fresh food and recycling of waste. In this review, information will be presented on the beneficial use of microbes in bioregenerative life support systems, their applicability to bISRU, and their capability to be genetically engineered for biotechnological space applications. In addition, we discuss the negative effect microbes and microbial communities may have on long-duration space travel and provide mitigation strategies to reduce their impact. Utilizing the benefits of microbes, while understanding their limitations, will help us explore deeper into space and develop sustainable human habitats on the Moon, Mars and beyond.
Relaxed targeting rules help PIWI proteins silence transposons
Authors: Gainetdinov Ildar , Vega-Badillo Joel , Cecchini Katharine , Bagci Ayca , Colpan Cansu , De Dipayan , Bailey Shannon , Arif Amena , Wu Pei-Hsuan , MacRae Ian J. , Zamore Phillip D. 
Published: June 2023

AbstractIn eukaryotes, small RNA guides, such as small interfering RNAs and microRNAs, direct AGO-clade Argonaute proteins to regulate gene expression and defend the genome against external threats. Only animals make a second clade of Argonaute proteins: PIWI proteins. PIWI proteins use PIWI-interacting RNAs (piRNAs) to repress complementary transposon transcripts1,2. In theory, transposons could evade silencing through target site mutations that reduce piRNA complementarity. Here we report that, unlike AGO proteins, PIWI proteins efficiently cleave transcripts that are only partially paired to their piRNA guides. Examination of target binding and cleavage by mouse and sponge PIWI proteins revealed that PIWI slicing tolerates mismatches to any target nucleotide, including those flanking the scissile phosphate. Even canonical seed pairing is dispensable for PIWI binding or cleavage, unlike plant and animal AGOs, which require uninterrupted target pairing from the seed to the nucleotides past the scissile bond3,4. PIWI proteins are therefore better equipped than AGO proteins to target newly acquired or rapidly diverging endogenous transposons without recourse to new small RNA guides. Conversely, the minimum requirements for PIWI slicing are sufficient to avoid inadvertent silencing of host RNAs. Our results demonstrate the biological advantage of PIWI over AGO proteins in defending the genome against transposons and suggest an explanation for why the piRNA pathway was retained in animal evolution.