bluuebunny/crossref_metadata_2025_split huggingface dataset:
About the Results of Vaccination against COVID-19 for Employees of a Cheboksary Medical Organization
Authors: Nikolaev N. S. , Nazarova V. V. , Pchelova N. N. , Preobrazhenskaya E. V. , Tarasova T. S. , Dobrovol'skaya N. Yu. 
Published: May 2023

Relevance. In the 21st century, humanity is faced with a pandemic unprecedented in recent history, which brought with it huge losses. All the efforts of world science are aimed at ensuring that the new coronavirus infection becomes vaccine-controlled. The Ministry of Health of Russia included vaccination against COVID-19 in the national calendar of preventive vaccinations. The most vulnerable and significant in the epidemiological chain are representatives of socially active, intensively communicating professions, including medical workers.Aims. The aim of the study was to assess the degree of severity of the post-vaccination immune response in employees of a medical organization vaccinated with the Gam-COVID-Vac preparation, who had not been ill and did not have antibodies before vaccination.Materials & Methods. The post-vaccination immunity of 80 vaccinated employees was assessed 42–62 days after the start of vaccination and 6 months later; assessment of the safety of vaccination with the Gam-Kovid-Vak vector vaccine; selection of optimal screening tests for laboratory examination of persons before the planned vaccination. The results of the PCR test for the detection of SARS-CoV-2 RNA (at the post-vaccination stage four times with an interval of 7 days) and the determination of M and G immunoglobulins to SARS-CoV-2 by the ELISA method were analyzed, postvaccination complications and reactions were assessed at different stages, monitoring the state of health and assessing the dynamics of the post-vaccination immune response.Results. A study conducted after 6 weeks showed the high immunological efficacy of the Gam-Covid-Vac vaccine; 100% of those vaccinated with one or two components of the vaccine had class G antibodies to SARS-CoV-2. Vaccination did not cause severe reactions during the observation period; among the side effects, general complaints and local pains at the injection site prevailed, which were of a short-term nature and did not have a significant impact on the health status and habitual rhythm of life of the participants. The resistance of those vaccinated to a new coronavirus infection decreased over time and amounted to 97.1% three months after vaccination and 95.6% after 6 months. COVID-19 disease in vaccinated employees (7.4% of cases of the number of vaccinated) was of moderate severity, did not lead to the development of pneumonia and respiratory failure, and did not require hospitalization.Conclusions. The results obtained allow us to conclude that the effectiveness of vaccination against COVID-19 is quite high. Revaccination is well tolerated clinically and «amplifies» the immune response when exposed to SARS-CoV-2. Immunization of employees of medical organizations is necessary, because. this focus group is the most epidemiologically potentially dangerous in terms of the spread of infection.
Effectiveness Analysis of a Compromise Approach to Solving the Problem of Refusal of Influenza Vaccination
Authors: Kolesin I. D. , Zhitkova E. М. 
Published: May 2023

Relevance. The ineffectiveness of current methods of engaging the population in vaccine prophylaxis leads to the need to develop new means of solving the problem of vaccination abandonment.Aims is to show the effect of applying the theory of compromise solutions to the analysis of the problem of refusal of influenza vaccination.Materials and methods. Data on number of vaccinated and morbidity among vaccinated and unvaccinated; the research method is based on the compilation of criteria reflecting the interests of the administration and the population, followed by finding a compromise solution and evaluating it using an indicator of tensions.Results. Based on data on morbidity among vaccinated and unvaccinated, the existence of an optimal percentage of vaccinated for the adult population and for each of the three risk groups is shown: medical staff, service employees and persons over 60 years of age; on the example of the group «persons over 60 years of age», the possibility of reducing tension in the case of replacing a single vaccination with a complex one is shown.Conclusion. The effectiveness of the application of the theory of compromise solutions to the assessment of tensions between the sanitary and epidemiological inspection service and the population in terms of vaccination is presented; the possibility of reducing tension by switching to complex immunoprophylaxis is presented.
PEMBERDAYAAN AISYIYAH DALAM MITIGASI COVID-19
Authors: Prastiwi Dani , Wahyuningsih Wahyuningsih , Anindhita Metha Anung 
Published: May 2023

<p class="Normal1">Sebaran kasus Covid-19 yang hingga kini masih flukuatif dengan berbagai pemberlakuan pembatasan kegiatan masyarakat membuat masyarakat masuk dalam fase relaps atau jenuh. Edukasi kepada masyarakat melalui pemberdayaan organisasi Aisyiyah diharapkan dapat menjadi role model dalam mengubah perilaku masyarakat. Kegiatan dilakukan dengan cara penyuluhan dan praktik pembuataan <em>liquid hand soap.</em> Sebanyak 17 anggota aktif terlibat sebagai peserta dalam kegiatan ini. Peserta merupakan ibu-ibu dengan mayoritas termasuk dalam usia produktif (35,29%), memiliki riwayat pendidikan SMA sederajat (82,36%) dan dengan pekerjaan sebagai ibu rumah tangga (70,60%). Capaian dari kegiatan ini adalah peserta dapat memahami bagaimana pencegahan covid-19, strategi mitigasi covid-19 dan pembuatan sabun cuci tangan.<em> </em>Evaluasi dilakukan dengan wawancara dan observasi langsung pembuatan sabun cuci tangan<em>.</em><em></em></p>
MULTIVITAMIN SEBAGAI UPAYA PENCEGAHAN STUNTING DAN PERTOLONGAN PERTAMA PADA ANAK TERSEDAK DI DESA KARANGANYAR BATANG
Authors: Mahfur Mahfur , Indriyono Anik 
Published: May 2023

<p>Karanganyar adalah salah satu desa di Kabupaten Batang dengan luas wilayah yang tidak terlalu luas akan tetapi jumah balita yang dimiliki tergolong tinggi. Pemerintah desa sangat aktif dalam melaksanakan program program yang berkaitan dengan tingkat kesehatan kepada masyarakat. Kegagalan pertumbuhan dapat disebabkan oleh kurangnya asupan gizi dalam seribu hari pertama kehidupan. Kondisi kegagalan pertumbuhan tersebut dapat dilihat dari anak tampak lebih pendek dibandingkan anak seusianya. Kondisi demikian dinamakan stunting. Stunting dialami pada tiga dari sepuluh anak balita. Tersedak merupakan kondisi gawat darurat yang harus cepat di tangani, bila terlalu lama akan mengakibatkan kekurangan oksigen dan mengakibatkan kematian karena kondisi tersumbatnya saluran pernafasan oleh benda asing yang berupa makanan, mainan, dan lain-lain (Putra, 2015). Tujuan dan target spesifik kegiatan ini adalah untuk menambah pehaman masyarakat desa karanganyar tentang penggunaan multivitamin sebagai upaya untuk penanggulangan stunting dan pertolongan pertama pada anak tersedak. Masyarakat lebih mengetahui berdasarkan pretest dan postest dengan hasil yang signifikan. Hasil yang diperoleh menunjukan bahwa terdapat penambahan pengetahuan dari para peserta pengabdian kepada masyarakat berkaitan dengan multivitamin, stunting, dan pertolongan pertama kasus tersedak, yang ditunjukan dari peningkatan nilai pos-test dan pre-test</p><p><strong>Kata Kunci </strong>: desa Karanganyar, multivitamin, tersedak, stunting</p>
Significant cultural patterns and their references in the poetry of Safi al-Din al-Hilli
Authors: Shnaweh Lect. Dr. Masar Ghazi 
Published: May 2023

The emergence of cultural criticism at the end of the last century brought about a qualitative leap in the field of critical practice as a whole, as we see a distinct shift from criticism of literature to criticism of culture, which has become a focused discourse in this field. Cultural criticism often embraces culture and never separates from it. Just as it takes from every science a party that combines contextual and systematic approaches, even theories of reading and reception, criticism of reader response and deconstruction, as it was based on psychology, sociology and history and relied on everything that would happen in addition to literature as a cultural phenomenon. It is striking that cultural criticism is based on a central idea that stems from and returns to, which is the criticism of fairness, especially the cultural defects that are implicit in every discourse or that are hidden behind the linguistic textual fabric. what they are.
Al-Hilli’s poetry conceals cultural patterns in which reality is critiqued from a behavioral, economic, political and religious point of view, providing the reader with an integrated picture of his society. We have relied on the categories of cultural criticism as a floating critical activity that refuses to fall under any approach, and uses procedural tools of various sources, which belong to different sciences such as anthropology, psychology, and history.
In order to answer the research questions and its problems, the research plan was as follows:
Introduction: I tried through it to provide an overview and familiarity with the subject and its basic forms.
The first requirement: the most important tributaries of cultural criticism and its background knowledge:
1: The concept of cultural pattern
2: systemic function
3: the cultural sentence
4: the cultural sentence
5: The total metaphor
* The second requirement: an overview of the social and poetic papers of the poet Safi al-Din al-Hilli (677-752 AH / 1277-1339 AD).
The manifestations of the wonders in the novel 'the Erasure Effect' by: Maytham Hashem Taher
Authors: Jihad Prof. Dr. Ahmed Hai , Khudair Ass. Lect.  Zahraa Aoun 
Published: May 2023

The erasure Effect is considered one of the Iraqi novels which delved into the depths of the texts to capture that unknown and tempts the to enter to those narrative realms which carry within them all that is strange and wondrous trying to reveal it indicating the most important conflicts that occur within them, whether they are with realistic or unreasonable events and outside of nature and do not harmonize with human reality, so that it will be a wonder for the recipient that the miraculous in the narration of 'The Erasure Effect' has manifested in its title, characters and events. The writer portrayed it with an amazing skill that amazes the reader and the recipient. This is all due to the author's ability to use the surprisingly imaginative side.
Ethnomathematics on bamboo woven crafts in Dusun Brajan, Yogyakarta and implementation in mathematics learning
Authors: Dewi Chintia Kurnia , Krisnamurti Cyrenia Novella 
Published: May 2023

. Indonesia is a country that is rich in natural and cultural resources. One of the cultures they have is fine arts. Fine art is one of the diverse cultures. This study examines one of the fine arts from Yogyakarta, namely woven bamboo. The famous woven bamboo handicraft industry comes from Dusun Brajan, Sendangagung, Kecamatan Minggir, Kabupaten Sleman, Yogyakarta. This study aims to determine the history of bamboo weaving activities, mathematical fundamental activities and implementation of bamboo weaving in Dusun Brajan in learning mathematics for junior high school students. The research method used is descriptive qualitative research with an ethnographic approach that aims to describe and assess the pattern of the bamboo craftsman group in Dusun Brajan. Data collection methods used were observation, documentation and interviews with the administrator of the Desa Wisata Brajan and the Dusun Brajan bamboo weaving craftsmen. The results of this study indicate the beginning of the development of woven bamboo crafts until now it has become a well-known craft centre. Through this woven bamboo, students can learn six basic math activities: counting, finding, measuring, designing, playing, and explaining. Implementation in learning mathematics in junior high schools is a contextual problem that can be used as discussion material for students.
Network analysis for identifying potential anti-virulence targets from whole transcriptome of Pseudomonas aeruginosa and Staphylococcus aureus exposed to certain anti-pathogenic polyherbal formulations
Authors: Ruparel Feny J. , Shah Siddhi K. , Patel Jhanvi H. , Thakkar Nidhi R. , Gajera Gemini N. , Kothari Vijay O. 
Published: May 2023

Introduction: Antimicrobial resistance (AMR) is a serious global threat. Identification of novel antibacterial targets is urgently warranted to help antimicrobial drug discovery programs. This study attempted identification of potential targets in two important pathogens Pseudomonas aeruginosa and Staphylococcus aureus.
Methods: Transcriptomes of P. aeruginosa and S. aureus exposed to two different quorum-modulatory polyherbal formulations were subjected to network analysis to identify the most highly networked differentially expressed genes (hubs) as potential anti-virulence targets.
Results: Genes associated with denitrification and sulfur metabolism emerged as the most important targets in P. aeruginosa. Increased buildup of nitrite (NO2) in P. aeruginosa culture exposed to the polyherbal formulation Panchvalkal was confirmed through in vitro assay too. Generation of nitrosative stress and inducing sulfur starvation seemed to be effective anti-pathogenic strategies against this notorious gram-negative pathogen. Important targets identified in S. aureus were the transcriptional regulator sarA, immunoglobulin-binding protein Sbi, serine protease SplA, the saeR/S response regulator system, and gamma-hemolysin components hlgB and hlgC.
Conclusion: Further validation of the potential targets identified in this study is warranted through appropriate in vitro and in vivo assays in model hosts. Such validated targets can prove vital to many antibacterial drug discovery programs globally.
Calibration of patient-specific boundary conditions for coupled CFD models of the aorta derived from 4D Flow-MRI
Authors: Black Scott MacDonald , Maclean Craig , Hall Barrientos Pauline , Ritos Konstantinos , McQueen Alistair , Kazakidi Asimina 
Published: May 2023

Introduction: Patient-specific computational fluid dynamics (CFD) models permit analysis of complex intra-aortic hemodynamics in patients with aortic dissection (AD), where vessel morphology and disease severity are highly individualized. The simulated blood flow regime within these models is sensitive to the prescribed boundary conditions (BCs), so accurate BC selection is fundamental to achieve clinically relevant results.Methods: This study presents a novel reduced-order computational framework for the iterative flow-based calibration of 3-Element Windkessel Model (3EWM) parameters to generate patient-specific BCs. These parameters were calibrated using time-resolved flow information derived from retrospective four-dimensional flow magnetic resonance imaging (4D Flow-MRI). For a healthy and dissected case, blood flow was then investigated numerically in a fully coupled zero dimensional-three dimensional (0D-3D) numerical framework, where the vessel geometries were reconstructed from medical images. Calibration of the 3EWM parameters was automated and required ~3.5 min per branch.Results: With prescription of the calibrated BCs, the computed near-wall hemodynamics (time-averaged wall shear stress, oscillatory shear index) and perfusion distribution were consistent with clinical measurements and previous literature, yielding physiologically relevant results. BC calibration was particularly important in the AD case, where the complex flow regime was captured only after BC calibration.Discussion: This calibration methodology can therefore be applied in clinical cases where branch flow rates are known, for example, via 4D Flow-MRI or ultrasound, to generate patient-specific BCs for CFD models. It is then possible to elucidate, on a case-by-case basis, the highly individualized hemodynamics which occur due to geometric variations in aortic pathology high spatiotemporal resolution through CFD.
Recent and projected changes in water scarcity and unprecedented drought events over Southern Pakistan
Authors: Ullah Irfan , Zeng Xin-Min , Hina Saadia , Syed Sidra , Ma Xieyao , Iyakaremye Vedaste , Yin Jun , Singh Vijay P. 
Published: May 2023

In recent decades, water scarcity is a significant constraint for socioeconomic development and threatens livelihood in an agriculture-based developing country like Pakistan. The water crisis in the country is projected to exacerbate in the coming years, especially in the southern parts. This dire situation calls for an investigation of major droughts, associated water scarcity, and changes in teleconnection patterns over Southern Pakistan. Moderate to low Southeastern monsoon (SEM) precipitation triggered the extreme drought episode (2017–2020) over Southern Pakistan and intensified the water scarcity. This study explored the severity of the respective drought event, underlying mechanisms, and changes in water scarcity over Southern Pakistan. To investigate the future changes (1980–2050) in water scarcity, coupling models (global hydrological models (GHMs)-global climate models (GCMs)) have been used to achieve the interannual performance of water availability and total water consumption. Besides, future scenarios used in this study are the combinations of SSPs and RCPs, including middle-of-the-road (SSP1-RCP4.5) and fossil-fueled development (SSP2-RCP8.5). The findings indicated a precipitation deficit of 45% during the 4-year (2017–2020), depicting the worst events in the past 50 years. South Pakistan observed the worst SEM droughts over the last 50 years, as 2000–2005 was the worst drought (precipitation deficit of 75%), followed by 2017–2020 with a 49% of precipitation deficit. Water scarcity was exacerbated by the extreme dry spells that developed over most of southern Pakistan between 2017 and 2020 as a result of moderate-to-exceptionally low SEM precipitation. Furthermore, this drought episode was accompanied by the cool phase in the Pacific and equatorial Indian Oceans. The future changes in water scarcity over the southern regions of Pakistan present a sharp increase under the SSP2-RCP8.5 scenario and are anticipated to be intensified in already stressed regions. This research is essential for environmentalists, and water resources managers, and provided crucial information to identify the hot spot areas in the target region so that water scarcity problems could be reduced in the future.
Pore structure and fractal characteristics of tight sandstone in meandering stream facies: a case study of the J2s2 member in the central Sichuan Basin, China
Authors: Feng Linjie , Jiang Yuqiang , Guo Guian , Yang Changcheng , Zhu Xun , Zeng Qinggao , Cai Guangyin , Wang Zhanlei 
Published: May 2023

Based on porosity and permeability tests, high-pressure mercury injection (HPMI), nuclear magnetic resonance (NMR) and centrifugal experiments, this study comprehensively analyzed the quality, pore structure and fractal characteristics of tight sandstone reservoir in meandering stream facies. The purpose is to reveal the relationship between physical properties, geometry and topological parameters of pores, fluid mobility and heterogeneity of pore system of tight sandstone reservoirs in meandering stream facies. The results show that the second member of the Middle Jurassic Shaximiao Formation (J2S2) in the central Sichuan Basin has developed tight sandstone reservoir of meandering fluvial facies, the pore radius of type I reservoir (K&gt;0.3 mD) is mainly distributed at 0.01 μm∼2 μm, the tortuosity ranges between 2.571 and 2.869, and the average movable fluid saturation is 70.12%. The pore radius of type II reservoir (0.08mD&lt;K&lt;0.3 mD) is mainly 0.003 μm∼1 μm, the tortuosity ranges between 2.401 and 3.224, the average movable fluid saturation is 57.59%. The pore radius of type III reservoir (K&lt;0.08 mD) is mainly 0.001 μm∼0.4 μm, the tortuosity ranges between 0.905 and 2.195, and the average movable fluid saturation is 13.46%. Capillary-Paraachor point (CP point) and T2 cut-off value (T2cutoff) are used to divide the fractal interval of capillary pressure curve and T2 spectrum. The fractal dimension Dh2 of small pores calculated by HPMI through 3D capillary tube model, the fractal dimension Dn1 of large pores and Dn2 of small pores calculated by NMR through wetting phase model can effectively characterize the heterogeneity of reservoir pores. Among them, Dn1 has a strong negative correlation with porosity, permeability, pore radius and movable fluid saturation, indicating that the reservoir capacity, seepage capacity and pore size are mainly controlled by large pores, therefore, Dn1 can be used as an effective reservoir evaluation parameter.
miRNA-1 promotes acute myeloid leukemia cell pathogenesis through metabolic regulation
Authors: Ghazaryan Arevik , Wallace Jared A. , Tang William W. , Barba Cindy , Lee Soh-Hyun , Bauer Kaylyn M. , Nelson Morgan C. , Kim Carissa N. , Stubben Chris , Voth Warren P. , Rao Dinesh S. , O’Connell Ryan M. 
Published: May 2023

Graphical AbstractWe blocked pyruvate entry into mitochondria and decreased Oxidative Phosphorylation (OXPHOS) in human AML cell lines MV4-11 and MOLM-14 by using gene editing tools. This metabolic shift led to increased expression of miR-1 in the human AML cell lines. TARGET and TCGA AML patient sample dataset analysis revealed that miR-1 is overexpressed in patients with FLT3-ITD + mutation, and independently from FLT3-ITD, high levels of miR-1 also correlates with reduced survival. Transcriptional and metabolic profiling of miR-1 overexpressing AML cells revealed that miR-1 promotes OXPHOS through glutaminolysis. Moreover, the overexpression of miR-1 in AML cells exacerbated disease in a mouse xenograft model. Together, our work expands current knowledge within the field by uncovering novel connections between AML cell metabolism and miRNA expression that facilitates disease progression. Created with BioRender.com.
GC/MS analysis of hypoxic volatile metabolic markers in the MDA-MB-231 breast cancer cell line
Authors: Issitt Theo , Reilly Matthew , Sweeney Sean T. , Brackenbury William J. , Redeker Kelly R. 
Published: May 2023

Hypoxia in disease describes persistent low oxygen conditions, observed in a range of pathologies, including cancer. In the discovery of biomarkers in biological models, pathophysiological traits present a source of translatable metabolic products for the diagnosis of disease in humans. Part of the metabolome is represented by its volatile, gaseous fraction; the volatilome. Human volatile profiles, such as those found in breath, are able to diagnose disease, however accurate volatile biomarker discovery is required to target reliable biomarkers to develop new diagnostic tools. Using custom chambers to control oxygen levels and facilitate headspace sampling, the MDA-MB-231 breast cancer cell line was exposed to hypoxia (1% oxygen) for 24 h. The maintenance of hypoxic conditions in the system was successfully validated over this time period. Targeted and untargeted gas chromatography mass spectrometry approaches revealed four significantly altered volatile organic compounds when compared to control cells. Three compounds were actively consumed by cells: methyl chloride, acetone and n-Hexane. Cells under hypoxia also produced significant amounts of styrene. This work presents a novel methodology for identification of volatile metabolisms under controlled gas conditions with novel observations of volatile metabolisms by breast cancer cells.