bluuebunny/crossref_metadata_2025_split huggingface dataset:
Early Life Stress Accelerates Critical Periods and Causes Precocious Visual Cortex Development
Authors: Poplawski Janet , Montina Tony , Metz Gerlinde 
Published: April 2023

Abstract
The developing nervous system displays remarkable plasticity in response to sensory stimulation during critical periods of development. Critical periods may also increase the brain’s vulnerability to adverse experiences. Here we show that early-life stress in mice shifts the timing of critical period of the visual cortex. Early-life stress accelerated the opening and closing of the visual cortex critical period along with precocious development of visual acuity. Premature emergence of inhibitory perineuronal nets was accompanied by activated energy metabolism and protein biosynthesis and expression of genes linked to psychiatric disease risk, with hemispheric asymmetries favoring the right side. Thus, early-life stress desynchronizes the orchestrated temporal sequence of regional brain development leading to permanent functional deficiencies. These findings provide new insights into the dichotomy between adaptive brain plasticity versus neurodevelopmental risk factors.
Multilevel analysis of the factors associated with teenage pregnancy Ethiopia; using the recent 2019 Ethiopia mini demographic and health survey
Authors: Abrham Angwach , Assefa Atersaw , Molla Ayenew , Kasu Alemayehu 
Published: April 2023

Abstract
Introduction: Teenage pregnancy is a major reproductive health problem. It can result in serious health and social issues. Even if teenage pregnancy has adverse obstetric and perinatal outcomes, the magnitude is still high in Ethiopia. Therefore, this study aimed to determine the magnitude and associated factors of teenage pregnancy.
Method: This study was based on the nationally representative 2019 Mini Ethiopian Demographic and Health Survey data. We used a total weighted sample of 2100 teenage in the survey. A multi-level logistic regression analysis was used to account for the hierarchal nature of the DHS data. In the multivariable multilevel analysis, those variables with p-value < 0.05 were considered as significantly associated with teenage pregnancy
Result: Based on this study result the prevalence of teenage pregnancy is 11.8%. Use of contraceptives (AOR=8.517832, 95% CI [5.241808, 13.8413]), household head age (AOR=6.031393, 95% CI: [3.850781, 9.446837]), educational stats (AOR=0.5053326, 95% CI [0.3261638, 0.7829227]), community wealth status (AOR=1.631567, 95% CI [0.9582524, 2.777985]) were factors significantly associated with teenage pregnancy.
Conclusion: Based on this study result the prevalence of teenage pregnancy among teenagers is still high. The multilevel modeling approach used in this study enables us to identify some factors at both the individual and community levels that are associated with teenage pregnancy. Educational status, household head age, contraceptive usage, and community wealth status have shown a significant positive association with teenage pregnancy.
Application of Computer Image Technology in 3D Painting Based on Cloud Computing
Authors: Li Yumei 
Published: April 2023

Abstract
Virtual painting technology is a new technical means of modern art creation. 3D painting is a branch of virtual reality art. It uses computers or other intelligent computing devices to simulate the virtual 3D space environment, so that art creators can immerse themselves in painting creation. The difference between 3D painting and traditional painting is that it is a painting space from two-dimensional to three-dimensional. It is a painting creation process of double immersion of human brain and limbs. We believe that the artistic exploration of 3D painting is helpful to the improvement of painting artistic creation ideas and the expansion of skills. It is an embodiment of enriching the media and visualization of painting. Due to the complexity of 3D painting, this paper creates a cloud platform based on the high-speed and large storage characteristics of cloud computing, which will provide more efficient and convenient experience for 3D painting users. The key to the development of the cloud platform is to build an NX digital modeling and display platform based on cloud computing. Through the compression, serialization and network transmission of the three-dimensional image technology at the NX end, the three-dimensional model is finally displayed in the browser interface, and the basic functions of interacting with the model are provided for users, Cloud computing technology is used to arrange the computing work of 3D model compression into subsequent computing, which greatly reduces the redundancy of users' work. Through the research of cloud computing, this paper applies it to computer image technology, which makes the application of 3D painting flourish.
Token Open Secure and Practical NTRU-based Updatable Encryption
Authors: Song Yang , Gao Haiying , Wang Shiyu , Ma Chao , Sun Keshuo 
Published: April 2023

Abstract

Updatable encryption (UE) is suitable for key rotation and ciphertexts update in the cloud storage environment. A new security model for UE named Token Open security model is presented recently, which is closer to the real attack scenario. And the existing post-quantum secure UE schemes are all based on the LWE assumption without engineering implementation. In this paper, we improve the recently presented security model, which allows the adversary to corrupt all update tokens and keys of the past epochs. We show that our new model reflects the characteristics of UE. Then we construct the first UE scheme based on NTRU, named NTRU-UE. Our new scheme uses the key-switching technique to achieve backward-leak uni-directional key update and uni-directional ciphertext update and uses the ciphertext-masking technique to achieve rand-update. We show that the new scheme is secure under our new model. In addition, we accomplish the software implementation of NTRU-UE and the experiment results show that the scheme meets the practical requirements.
A chromosome arm from Thinopyrum intermedium × Thinopyrum ponticum hybrid confers increased tillering and yield potential in wheat
Authors: Türkösi Edina , Szakács Éva , Ivanizs László , Farkas András , Gaál Eszter , Said Mahmoud , Darkó Éva , Cséplő Mónika , Mikó Péter , Doležel Jaroslav , Molnár-Láng Márta , Molnár István , Kruppa Klaudia 
Published: April 2023

Abstract
Tiller number is a key component of plant architecture with direct effect on grain yield of wheat. Interspecific hybridization using wild relative species are promising approach for increasing wheat genetic diversity, including yield potential. Agropyron glael, a perennial hybrid of Thinopyrum intermedium and Th. ponticum has five subgenomes (J, Jst, Jvs, Jr, and St), making A. glael an important gene source for transferring useful agronomical traits into wheat.
This work reports on development of a wheat-A. glael translocation line WT153397. Sequential in situ hybridizations with J-, St-, and D-genomic DNA probes and pSc119.2, Afa family, pTa71, and (GAA)7 DNA repeats, as well as an analysis using molecular markers specific for the wheat 6D chromosome, revealed the presence of a 6DS.6Jvs centric fusion in the translocation line.
Field trials in low-input and high-input breeding nurseries over three growing seasons demonstrated high compensating ability of the Agropyron chromosome arm for the missing 6DL as spike morphology and fertility of WT153397 did not differ significantly from those of wheat parents. Moreover, the introgressed 6Jvs chromosome arm significantly increased the number of productive tillers, which manifested in the significantly higher grain yield potential relative to the parental wheat cultivars.
The translocated chromosome could be flow-sorted in high purity providing an opportunity to employ chromosome genomics to identify Agropyron gene variant(s) responsible for the tillering capacity. The translocation line WT153397 represents an important genetic stock for functional genetic studies of tiller formation and useful breeding material to increase wheat yield potential.
Predictive value of m1A-related genes in kidney renal clear cell carcinoma
Authors: Zhang Tengfei , Yang Ning , Lei Xu , Jiang Tao , Dong Botao 
Published: April 2023

Abstract
Background：Kidney renal clear cell carcinoma (KIRC) is a prevalent type of renal malignancy characterized by high mortality rates and poor response to treatment. N1-methyladenosine (m1A) is a type of RNA methylation modification that has received considerable attention due to its crucial roles in various biological functions. With the advancement of genomics and molecular biology, m1A-related genes (m1A RGs) have been confirmed to be intimately connected with the development and occurrence of various tumors. Nevertheless, the role of m1A RGs in KIRC remains poorly understood.
Methods：This study aims to investigate the prognostic significance of 10 major m1A RGs in KIRC patients, utilizing data from The Cancer Genome Atlas (TCGA) dataset. A prognostic model was constructed using Lasso regression analysis, and risk scores were calculated. KIRC patients were classified into high- and low-risk groups based on the median of the average risk score. The prognostic value of the model was evaluated using two independent datasets, GSE537574 and GSE265745, by assessing the sensitivity and specificity using Kaplan-Meier survival analysis and receiver operating characteristic curves. Additionally, gene set enrichment analysis was conducted to explore the possible biological behavior and pathways of m1A RGs. Ultimately, 5 m1A RGs were identified to construct the prognostic model. Furthermore, nomogram and decision curve analyses were performed to evaluate the model's predictive performance and clinical application value.
Results：Our study demonstrates that the expression of m1A RGs might serve as a prognostic biomarker for KIRC patients and provides a new perspective for cancer prognosis screening in clinical practice.
Association between TIMP1 gene polymorphism and glioma in a northern Chinese population
Authors: Chen Weifeng , Li Xiaopeng , Zhang Hanfei , Zhang Jinxia , Zhao Chunmei , Wang Junhui 
Published: April 2023

Abstract
Aims
To explore the association between two polymorphisms of TIMP1 and the risk of glioma in the northern Chinese population.
Methods
Genotyping of TIMP1 polymorphisms (rs4898 and rs2070584) was performed in 310 glioma patients and 350 healthy controls (HCs) from north China using the SNaPshot sequencing technique. Survival data from patients with glioma were analyzed.
Results
The frequency of the rs4898-C, rs2070584-G alleles were significantly lower in male glioma patients than those in HCs (p < 0.05). The frequency of heterozygote genotype (CT) was significantly lower in the patient group than control (OR = 0.49, 95%CI = 0.30–0.80, P = 0.004). For rs2070584, the frequency of heterozygote genotype (GT) was significantly lower in the patient group than control (OR = 0.63, 95%CI = 0.42–0.95, P = 0.026). The frequency of hemizygote C on rs4898 was lower for WHO III~Ⅳ glioma cases than for HCs (OR = 0.36, 95%CI = 0.17–0.73, P = 0.004). Haplotype analysis showed TIMP1 C-G (rs4898-rs2070584) frequency was lower in male glioma patients (OR = 0.80, 95%CI = 0.66–0.98, P = 0.034). The risk of OS for glioma patients carrying the rs4898 TT genotype increased by about 1.377-fold in comparison with CC + CT genotype patients (95%CI = 1.044 ~ 1.817, P = 0.024). Similarly, the risk of PFS for glioma patients carrying the rs2070584 TT genotype increased by about 1.347-folds in comparison with GG + GT genotype patients (95%CI = 1.051 ~ 1.727, P = 0.019).
Conclusions
In conclusion, the present study suggested that genetic polymorphisms of TIMP1 were associated with glioma risk in the Chinese population.; Rs4898 CT heterozygote and hemizygous C might be protective against glioma; the haplotype C-G (Rs4898-rs2070584) provides nearly 80% protection towards the development of glioma. Furthermore, TIMP1 polymorphisms (rs4898 and rs2070584) might be an independent prognostic factor in glioma patients.
MTGAE: Graph Autoencoder with Mirror TCN for Traffic Anomaly Detection
Authors: Ren Zhiyu , Li Xiaojie , Wu Xi , Peng Jing , Chen Ken , Tan Qushan , Shi Canghong 
Published: April 2023

Abstract
Traffic time series anomaly detection has been intensively studied for years because of its potential applications in intelligent transportation. Classical traffic anomaly detection methods ignore the hidden dynamic associations between road network nodes as it evolves, resulting in the inability to capture the long-term temporal correlation, spatial and temporal characteristics of traffic data, and the abnormal nodes from it in a dataset with high periodicity and trends (e.g., morning peak travel). In this paper, we proposed a Mirror Temporal Graph Autoencoder (MTGAE) framework to explore anomalies and capture unseen nodes and the spatiotemporal correlation between nodes in the traffic network. In the method, we propose Mirror Temporal Convolutional Module (MTCM) module, to our best knowledge, which possesses better feature extraction and captures hidden node-to-node features in the traffic network and will be passed as hidden to the next module. Our proposed Graph Convolutional Gate Recurrent Unit Cell (GCGRU CELL) module, mapped to a high-dimensional space by Gaussian kernel functions, which discerns anomalous information in the traffic network and possible anomalies in the complex interdependencies between nodes and nodes based on prior knowledge and input data. We compared our work with several other advanced deep-learning anomaly detection models. The experimental results on the NYC dataset prove that our model works best compared to other models for traffic anomaly detection.
Reassessing the safety of dietary emulsifiers through the lens of gut microbiota
Authors: Panyod Suraphan , Wu Wei-Kai , Chang Chih-Ting , Wada Naohisa , Ho Han-Chen , Chen Rou-An , Huang Huai-Syuan , Liu Po-Yu , Chen Yi-Hsun , Chuang Hsiao-Li , Shen Ting-Chin David , Tang Sen-Lin , Ho Chi-Tang , Wu Ming-Shiang , Sheen Lee-Yan 
Published: April 2023

Abstract

Dietary emulsifiers have been linked to various diseases. The recent discovery of the role of gut microbiota-host interactions on health and disease warrants the safety reassessment of dietary emulsifiers through the lens of gut microbiota. Hydrophilic (lecithin (LEC), sucrose esters (SUC), carboxymethylcellulose (CMC)) and lipophilic (mono- and diglycerides (MDG)) emulsifiers are common dietary emulsifiers with high exposure levels in the population. This study proved that SUC and CMC induced hyperglycemia and hyperinsulinemia. MDG impaired circulating lipid and glucose metabolism. Both hydrophilic and lipophilic emulsifiers changed the intestinal microbiota diversity and induced gut microbiota dysbiosis. Hydrophilic emulsifiers have no impact on mucus–bacterial interactions, whereas MDG tended to cause bacterial encroachment into the inner mucus layer and enhance inflammation potential by raising circulating lipopolysaccharide. Our findings demonstrated the safety concerns associated with using dietary emulsifiers, suggesting that they could lead to metabolic syndromes.
Multifaceted involvement of ACBD6 in the metabolic reprogramming of breast cancer
Authors: Xing Zeyu , Cao Heng , Zhang Menglu , Liu Jiaqi , Wu Jiang , Ren Fei , Feng Kexin , Wang Yipeng , Wang Xiang 
Published: April 2023

Abstract
Introduction: Serving as the key intermediate in metabolic pathways, acyl-CoA is coordinated by various acyl-CoA binding domain containing proteins (ACBDs). ACBD6 is a crucial member of the ACBD family, and previous studies have indicated its potential in tumorigenesis and cancer progress. However, the clinical relevance of ACBD6 in breast cancer is still elusive. The objective of this study is to investigate the association between ACBD6 expression and other clinicopathological features of breast cancer, furtherly explore its specific role in metabolism and prognostic value.
Methods: We retrospectively analyzed 90 patients and used immunohistochemical staining to determine their ACBD6 statuses. Web platforms are also used to analyze ACBD6.
Results: Results showed that patients with high ACBD6 expression tend to be older, more likely to be progesterone receptor negative, and more often classified into triple-negative breast cancer. Web platforms such as LinkedOmics and BCIP uniformly confirm that ACBD6 level is elevated in breast cancerous tissues. Higher expression of ACBD6 is associated with more aggressive clinicopathological features, as well as worse prognosis.
Conclusions: ACBD6 assists with N-myristoyltransferase enzymes to functionally support glycine myristoylation, and interacts with lysophospholipid-acyltransferase enzymes, protecting the integrity of membrane lipid bilayer from the destructive nature of acyl-CoA. Also, ACBD6 could influence hematopoiesis and vascular endothelium development. Despite precise cognition remains scarce, ACBD6 multi-functionally works in the occurrence and metabolic reprogramming of breast cancer. Further researches are deserved to elucidate the biological mechanisms, prognostic and therapeutic value of ACBD6.
Changes of naturally occurring antibodies against ASC in healthy Chinese population
Authors: Zhu XiaoPeng , Yu HaiJing , Long Yan , Liu He , Lai Xia , Huang Liang , Gao Xia , Deng Juan 
Published: April 2023

Abstract
Background
To explore the changes of in human plasma Naturally occurring antibodies against ASC (NAbs-ASC) in healthy Chinese population .
Methods
A total of 97 young, 99 middle-aged and 108 elderly subjects were recruited from the Health Management Department of Daping Hospital, Army Medical University. The medical history data of the three groups and plasma levels of NAbs-ASC were compared to analyze changes of their and correlation in aging .
Results
Naturally occurring antibodies against ASC were present in human plasma and a one-way ANOVA yielded significantly lower plasma levels of NAbs-ASC in the elderly group relative to the young (2421.15 vs 2849.26, p < 0.001) and middle-aged groups (2421.15 vs 2878.44, p < 0.001); plasma levels of NAbs-ASC in the young group were not statistically different from those in the middle-aged group (2849.26 vs 2878.44, p = 0.576). Spearman's correlation analysis showed a negative correlation between age and plasma NAbs-ASC levels (r=-0.265, p < 0.001).
Conclusion
NAbs-ASC is widely present in human plasma and reduced in the plasma of elderly people and negatively correlated with age.
New insights of a stochastic nonlinear differential equations model with ergodic stationary distribution via fractal-fractional derivatives involving random perturbations
Authors: Chu Yu-Ming , Sultana Sobia , Karim Shazia , Alharthi Mohammed Shaaf , Rashid Saima 
Published: April 2023

Abstract
Rumor circulation has been a serious challenge to preserving the established societal structure. Recently, significant attempts have been made to explore the patterns of rumors using epidemic models, assuming that only rumor streams for a particular incident occur in the network. In this research, the rumor dynamics during catastrophes are discussed using a unique rumor spreading mechanism via the novel fractal-fractional derivative operators (Caputo and Caputo-Fabrizio) sense by proposing white noise in the system. By strengthening a comprehensive stochastic Lyapunov function, which gives us a reasonable representation of permanence. Furthermore, we established the existence-uniqueness of the non-negative solution of the model. Besides that, we are capable of demonstrating the necessary requirements for the persistence and exclusivity of an ergodic stationary distribution for the aforesaid model. Numerical configurations were investigated to illustrate the effect of model parameters, power law and exponential decay kernel with fractional-order and fractal-dimension on the rumor metastatic phenomenon. Finally, the corresponding management solutions with the fractal-fractional operators for preventing the proliferation of rumors during catastrophes are also covered in this research.
AMS Subject Classification: 26A51; 26A33; 26D07; 26D10; 26D15.
Analyzing the change in land cover dynamics: A case study of Delhi
Authors: Singh Sangita , Sarma Kiranmay 
Published: April 2023

Abstract
land use/land cover change analysis is one of the key strategies for managing and tracking natural resources and monitoring as well as mapping the shift. The major contributor to such changes is urbanization. These types of changes are very prominent in metropolitan cities where the population load is high. The study area selected for the present study is Delhi, the National capital of India. This article compares the changes in land use and land cover from 2014 to 2023. To map the changes Landsat 8 data were used for 2014 and Landsat 9 was used for 2023. A total of five classes were selected for the analysis: vegetation, built-up, scrubland, waterbody, and agriculture for both datasets. The images were classified with a maximum likelihood algorithm and the overall accuracy attained was 86% (kappa 0.82) for 2014 and 90% (kappa 0.87) for 2023. The change detection suggested that there is an increase in land cover for built-up (+ 3.80) and also in the natural vegetation (+ 5.49) and a decline was observed in scrubland (-1.51) and agricultural areas (-7.91). Apart from the change detection map, a composite map for each class was also prepared for better understanding. In concluding remarks data on urban growth, land use, and land cover change studies are very important for local government and urban planners to create future plans for the sustainable development of the city.
Rapid assay using recombinase polymerase amplification and lateral flow dipstick for identifying Agrilus mali, a serious wood-boring beetle of the western Tianshan Mountains in China
Authors: Li Cheng-Jin , Sun Hui-Quan , Zhao Wen-Xia , Wang Xiao-Yi , Lin Ruo-Zhu , Yao Yan-Xia 
Published: April 2023

Abstract
Agrilus mali is a major wood-boring pest of Northeast Asia. Recently, it destroyed Malus sieversii and caused the decline of the wild fruit forests of the Tianshan Mountains in the Xinjiang Uygur Autonomous Region, China. The pest beetle is often not identified due to the absence of affective rapid discrimination methods beyond adult morphological examination. This study reports a simple, rapid, specific and sensitive method based on recombinase polymerase amplification (RPA) combined with lateral flow dipstick (LFD), which is able to quickly define the beetle even when it is young. RPA primers were designed based on the internal transcribed spacer 1 region (ITS1). The introduction of the probe in the reaction eliminated the false-positive signals. The probe (Probe1-b) was specificity and sensitivity with as little as 10-3 ng of purified DNA needed to detect A. mali. Moreover, the RPA reaction was carried out using crude extracted DNA, which was only extracted by immersion in sterile distilled water. The LFD is used to visualize the detection results. The results show that the whole process of the RPA-LFD assay can be completed at 38 °C in approximately 30 min, including 10 min for A. mali gDNA extraction and 15 min for RPA-LFD detection, and the amplification can be carried out in an individual’s hand; thus, this method has very good application prospects in the field of quarantine and pest management.