bluuebunny/crossref_metadata_2025_split huggingface dataset:
Das entfremdete Selbst, die entfremdete Umwelt
Authors: Macchia Ana , Malejko Kathrin , Abler Birgit 
Published: March 2023

ZUSAMMENFASSUNGObwohl Dissoziation einer der ältesten Forschungsgegenstände der Psychiatrie darstellt, bleibt sie bis heute ein vage definiertes und mannigfaltiges Konstrukt. Ausgeprägte dissoziative Symptome sind für eine Subgruppe von Patienten mit Borderline-Persönlichkeitsstörung (BPS) und posttraumatischer Belastungsstörung (PTBS) charakteristisch und von hoher klinischer Relevanz mit Prävalenzen von 19–34 % bei BPS und bis zu 60 % bei PTBS. Insbesondere Veränderungen der psychischen Integrität mit einer Entfremdung von Selbst und Umwelt (Derealisation/Depersonalisation) gehen mit einer ausgeprägteren BPS- und PTBS-Symptomatik sowie riskanten Verhaltensweisen wie Selbstverletzung und Suizidalität einher. Dissoziative Symptome können nach dem aktuellen Kenntnisstand als eine unwillkürliche und automatische maladaptive Form der Emotionsregulation eingestuft werden, bei welcher subjektiv eine Distanz zu internalen oder externalen bedrohlichen Ereignissen hergestellt wird, die aber objektiv mit einer erhöhten Stressreaktion und autonomer Erregung aufzutreten scheint. Insbesondere bei der BPS wirken sich dissoziative Symptome negativ auf das Behandlungsergebnis aus, während die konkrete Adressierung von Dissoziationen beispielsweise durch Psychoedukation, Achtsamkeit oder Fertigkeitentraining Therapieerfolge verbessert.
Therapiekonzepte der anthroposophischen Medizin bei Allergien
Authors: Roemer Franziska 
Published: March 2023

SummaryDie Zahl der von saisonalen Allergien Betroffenen nimmt jedes Jahr zu. Der erste Griff ist dann meist zu OTC-Medikamenten, die aber den Körper nicht nur belasten können, sondern die auch keine Heilung erzielen. Die Anthroposophische Medizin mit ihren vielfältigen Möglichkeiten bietet bei Allergien jedoch einen schonenden und dabei äußerst umfassenden und wirksamen Ansatz.
Relationship Between Body Size and Skeletal Age with Muscle Damage in
Young Soccer Players
Authors: Ramos-Silva Luiz Fernando , Costa Julio Cesar , Borges Paulo Henrique , Moura Felipe A , Deminice Rafael , de Oliveira Donizete Cícero Xavier , Osiecki Raul , Vaz Ronque Enio Ricardo 
Published: March 2023

AbstractThis study verified the relationship between body size and skeletal age (SA) with
the behavior of blood markers of muscle damage and delayed onset muscle soreness
(DOMS) after a soccer match in the U-13 and U-15 categories. The sample
consisted of 28 soccer players in the U-13 and 16 in the U-15 categories.
Creatine kinase (CK), lactate dehydrogenase (LDH), and DOMS were evaluated up to
72 h after the match. Muscle damage was elevated at 0 h in U-13,
and from 0 h to 24 h in U-15. DOMS increased from 0 h to
72 h in U-13 and from 0 h to 48 h in U-15. Significant
associations of SA and fat-free mass (FFM) with muscle damage markers and DOMS
were observed only in U-13, specifically at time 0 h, when SA explained
56% of CK and 48% of DOMS and FFM explained 48% of DOMS.
We concluded that in the U-13 category, higher SA is significantly associated
with muscle damage markers, and increase in FFM is associated with muscle damage
markers and DOMS. Furthermore, U-13 players need 24 h to recover
pre-match muscle damage markers and more than 72 h to recover DOMS. In
contrast, the U-15 category needs 48 h to recover muscle damage markers
and 72 h to recover DOMS.
Clinicopathological Significance and Prognostic Role of Her2neu Protein Expression in Patients with Carcinoma Stomach: A Prospective Study from Northern India
Authors: B. Abhilash V. , Behera Manas Kumar , Patne Shashikant C. U. , Shukla Sunit Kumar , Dixit Vinod Kumar 
Published: March 2023

Background and Aims Gastric cancer is the third most common cause of cancer-related mortality worldwide after lungs and colorectum. Although controversial, Her2neu overexpression by immunohistochemistry is usually associated with poor prognosis in patients with carcinoma stomach. We conducted a prospective study to evaluate the prognostic role of Her2neu and its correlation with clinical, pathologic type, and stage of the disease.Methods A prospective study was performed on paraffin blocks of 111 gastric cancer specimens (88 patients were biopsy specimens and 23 were gastrectomy specimens). The paraffin blocks were processed for Her2neu receptor immunohistochemical staining and fluorescence in situ hybridization, and scoring was done.Results Her2neu overexpression was detected in 30 out of 111 (27%) patients. The mean age was 57.68 ± 12.82 years, with males constituting two-thirds of total patients. Tobacco addiction was found in 44% of the patients and smoking in 33% of the patients. Her2neu expression was similar in Lauren's intestinal and diffuse histologic type; however, proximal gastric tumors overexpressed Her2neu as compared with distal tumors. Her2neu 2+ or 3 + (odds ratio: 2.52, 95% CI: 1.61–3.95, p = 0.001) was the only independent predictor of survival in gastric cancer patients. Kaplan–Meir survival analysis showed that the survival of gastric cancer patients with Her2neu overexpression (Her2neu 2+ or 3 + ) was significantly lower than that of those with Her2neu nonexpression (p = 0.001).Conclusion Her2neu positivity was a significant predictor of mortality in patients with carcinoma stomach, and Her2neu overexpression was associated with a lower overall survival rate compared with Her2neu nonexpression.
MR Imaging of the Developing Pediatric Marrow: An Overview of Pearls and Pitfalls
Authors: Igbinoba Zenas , Jaramillo Diego 
Published: March 2023

AbstractThe dynamic and developing pediatric skeleton is a well-elucidated process that occurs in a stepwise faction. Normal development has been reliably tracked and described with Magnetic Resonance (MR) imaging. The recognition of the normal patterns of skeletal development is essential, as normal development may mimic pathology and vice versa. The authors review normal skeleton maturation and the corollary imaging findings while highlighting common marrow imaging pitfalls and pathology.
Bidirectional transmission of a collimator with double-combined collimating lenses and thermally expanded core fibers
Authors: Zhao Zhengang , Duan Shaofeng , Xu Xiaoping , Wang Sifei , Wan Xiaorong 
Published: March 2023

The collimator is an essential part of the fiber optic rotary joint design. This study proposes the Large-Beam Fiber Collimator (LBFC) with a double collimating lens and a Thermally Expanded Core (TEC) fiber structure. The transmission model is constructed based on the defocusing telescope structure. The effects of TEC fiber’s mode field diameter (MFD) on the coupling loss are investigated by deriving the loss function for the influence of collimator mismatch error and implementing it on a fiber Bragg grating temperature sensing system. The experimental results show that the coupling loss decreases with the increase of the MFD of TEC fiber, while the coupling loss is less than 1 dB when the mode field diameter is greater than 14 µm. TEC fibers can reduce the effect of angular deviation. Considering the coupling efficiency and deviation, the preferred mode field diameter for the collimator is 20 µm. The proposed LBFC enables bidirectional transmission of optical signals for temperature measurement.
The ro-vibrational ν2 mode spectrum of methane investigated by ultrabroadband coherent Raman spectroscopy
Authors: Mazza Francesco , Thornquist Ona , Castellanos Leonardo , Butterworth Thomas , Richard Cyril , Boudon Vincent , Bohlin Alexis 
Published: March 2023

We present the first experimental application of coherent Raman spectroscopy (CRS) on the ro-vibrational ν2 mode spectrum of methane (CH4). Ultrabroadband femtosecond/picosecond (fs/ps) CRS is performed in the molecular fingerprint region from 1100 to 2000 cm−1, employing fs laser-induced filamentation as the supercontinuum generation mechanism to provide the ultrabroadband excitation pulses. We introduce a time-domain model of the CH4ν2 CRS spectrum, including all five ro-vibrational branches allowed by the selection rules Δv = 1, ΔJ = 0, ±1, ±2; the model includes collisional linewidths, computed according to a modified exponential gap scaling law and validated experimentally. The use of ultrabroadband CRS for in situ monitoring of the CH4 chemistry is demonstrated in a laboratory CH4/air diffusion flame: CRS measurements in the fingerprint region, performed across the laminar flame front, allow the simultaneous detection of molecular oxygen (O2), carbon dioxide (CO2), and molecular hydrogen (H2), along with CH4. Fundamental physicochemical processes, such as H2 production via CH4 pyrolysis, are observed through the Raman spectra of these chemical species. In addition, we demonstrate ro-vibrational CH4v2 CRS thermometry, and we validate it against CO2 CRS measurements. The present technique offers an interesting diagnostics approach to in situ measurement of CH4-rich environments, e.g., in plasma reactors for CH4 pyrolysis and H2 production.
Fault diagnosis for rotor based on multi-sensor information and progressive strategies
Authors: Hu Xiao , Wei Daohong , Liu Dong , Xiao Zhihuai , Xia Xiangchen , Malik O P 
Published: March 2023

Abstract
Fault diagnosis is an effective tool to ensure safe operation of machinery and avoid serious accidents. As most currently used fault diagnosis methods usually employ mapping relationship established by training samples and their labels to achieve classification of testing samples, it is difficult for them to achieve fault diagnosis under the condition of incomplete training sample types. In addition, previous studies usually focus on feature extraction of single-channel vibration signal, which cannot get complete fault feature information. To solve the above problems, a progressive fault diagnosis method is investigated in this paper. First, the preliminary fault detection for the rotor is performed by studying reconstruction error of a sparse auto-encoder. Second, if a fault exists in the rotor, the outlier detection is implemented by the support vector data description method. Finally, if there are no outlier samples, the well -trained support vector machine is used to confirm the type of fault samples and complete the diagnosis. The performance of the proposed method was verified using the data obtained from a rotor laboratory bench. The types of rotor states investigated include normal, contact-rubbing, unbalance and misalignment. The experimental results verify the effectiveness and superiority of the proposed method in reducing the incidents of fault omission and fault misunderstanding.
Energy efficiency evaluation of a three-phase extendable-level inverter
Authors: Aishwarya V , Gnana Sheela K 
Published: March 2023

Abstract
This paper details the energy efficiency evaluation of an Extendable-Level Inverter (ELI). ELI achieves very high voltage levels, excellent DC-link utilization, and very good power quality with a minimized component count. An experimental setup of a three-phase ELI is implemented to investigate the power losses and to calculate efficiency. The ELI obtained a high efficiency of 99.09% with reduced switching and conduction power losses of 0.1% and 0.81% respectively. Comparative analysis of the theoretical calculation, simulation results and hardware results validated the consistency of a very high efficiency of over 99.09% for a broad range of operating frequencies. The power quality metrics conformed to the limits prescribed in the IEEE 519 standard.
Beyond antibody fucosylation: α-(1,6)-fucosyltransferase (Fut8) as a potential new therapeutic target for cancer immunotherapy
Authors: Mao Changchuin , Li Jun , Feng Lili , Gao Wenda 
Published: March 2023

AbstractAberrant post-translational glycosylation is a well-established hallmark of cancer. Altered core fucosylation mediated by α-(1,6)-fucosyltransferase (Fut8) is one of the key changes in tumor glycan patterns that contributes to neoplastic transformation, tumor metastasis, and immune evasion. Increased Fut8 expression and activity are associated with many types of human cancers, including lung, breast, melanoma, liver, colorectal, ovarian, prostate, thyroid, and pancreatic cancer. In animal models, inhibition of Fut8 activity by gene knockout, RNA interference, and small analogue inhibitors led to reduced tumor growth/metastasis, downregulation of immune checkpoint molecules PD-1, PD-L1/2, and B7-H3, and reversal of the suppressive state of tumor microenvironment. Although the biologics field has long benefited tremendously from using FUT8−/− Chinese hamster ovary cells to manufacture IgGs with greatly enhanced effector function of antibody-dependent cellular cytotoxicity for therapy, it is only in recent years that the roles of Fut8 itself in cancer biology have been studied. Here, we summarize the pro-oncogenic mechanisms involved in cancer development that are regulated by Fut8-mediated core fucosylation, and call for more research in this area where modifying the activity of this sole enzyme responsible for core fucosylation could potentially bring rewarding surprises in fighting cancer, infections, and other immune-related diseases.
Improving annotation propagation on molecular networks through random walks: introducing ChemWalker
Authors: Borelli Tiago Cabral , Arini Gabriel Santos , Feitosa Luís G P , Dorrestein Pieter C , Lopes Norberto Peporine , da Silva Ricardo R 
Published: March 2023

AbstractMotivationAnnotation of the mass signals is still the biggest bottleneck for the untargeted mass spectrometry analysis of complex mixtures. Molecular networks are being increasingly adopted by the mass spectrometry community as a tool to annotate large-scale experiments. We have previously shown that the process of propagating annotations from spectral library matches on molecular networks can be automated using Network Annotation Propagation (NAP). One of the limitations of NAP is that the information for the spectral matches is only propagated locally, to the first neighbor of a spectral match. Here, we show that annotation propagation can be expanded to nodes not directly connected to spectral matches using random walks on graphs, introducing the ChemWalker python library.ResultsSimilarly to NAP, ChemWalker relies on combinatorial in silico fragmentation results, performed by MetFrag, searching biologically relevant databases. Departing from the combination of a spectral network and the structural similarity among candidate structures, we have used MetFusion Scoring function to create a weight function, producing a weighted graph. This graph was subsequently used by the random walk to calculate the probability of ‘walking’ through a set of candidates, departing from seed nodes (represented by spectral library matches). This approach allowed the information propagation to nodes not directly connected to the spectral library match. Compared with NAP, ChemWalker has a series of improvements, on running time, scalability and maintainability and is available as a standalone python package.Availability and implementationChemWalker is freely available at https://github.com/computational-chemical-biology/ChemWalkerContactridasilva@usp.brSupplementary informationSupplementary data are available at Bioinformatics online.
Properties of REM sleep alterations with epilepsy
Authors: Ikoma Yoko , Takahashi Yusuke , Sasaki Daichi , Matsui Ko 
Published: March 2023

Abstract
It is usually assumed that individuals rest during sleep. However, coordinated neural activity that presumably requires high energy consumption is increased during REM sleep. Here, using freely moving male transgenic mice, the local brain environment and astrocyte activity during REM sleep were examined using the fibre photometry method with an optical fibre inserted deep into the lateral hypothalamus, a region that is linked with controlling sleep and metabolic state of the entire brain. Optical fluctuations of endogenous autofluorescence of the brain parenchyma or fluorescence of sensors for Ca2+ or pH expressed in astrocytes were examined. Using a newly devised method for analysis, changes in cytosolic Ca2+ and pH in astrocytes and changes in the local brain blood volume (BBV) were extracted. On REM sleep, astrocytic Ca2+ decreases, pH decreases (acidification) and BBV increases. Acidification was unexpected, as an increase in BBV would result in efficient carbon dioxide and/or lactate removal, which leads to alkalinization of the local brain environment. Acidification could be a result of increased glutamate transporter activity due to enhanced neuronal activity and/or aerobic metabolism in astrocytes. Notably, optical signal changes preceded the onset of the electrophysiological property signature of REM sleep by ∼20–30 s. This suggests that changes in the local brain environment have strong control over the state of neuronal cell activity. With repeated stimulation of the hippocampus, seizure response gradually develops through kindling. After a fully kindled state was obtained with multiple days of stimuli, the optical properties of REM sleep at the lateral hypothalamus were examined again. Although a negative deflection of the detected optical signal was observed during REM sleep after kindling, the estimated component changed. The decrease in Ca2+ and increase in BBV were minimal, and a large decrease in pH (acidification) emerged. This acidic shift may trigger an additional gliotransmitter release from astrocytes, which could lead to a state of hyperexcitable brain. As the properties of REM sleep change with the development of epilepsy, REM sleep analysis may serve as a biomarker of epileptogenesis severity. REM sleep analysis may also predict whether a specific REM sleep episode triggers post-sleep seizures.
Recurrent cardiovascular events in patients with type 2 diabetes and haemodialysis: analysis from the 4D Study
Authors: Marx Nikolaus , Wanner Christoph , Jankowski Joachim , März Winfried , Krane Vera , Genser Bernd 
Published: March 2023

ABSTRACT

Background
In the ‘Die Deutsche Diabetes Dialyse Studie’ (4D Study), treatment of patients with type 2 diabetes mellitus (T2DM) on haemodialysis (HD) with atorvastatin compared with placebo had no significant effect on the first composite primary major adverse cardiovascular event (MACE) endpoint of death from cardiac causes, fatal stroke, non-fatal myocardial infarction or non-fatal stroke. In this study we analysed first and recurrent events in 1255 patients from the 4D Study.

Methods
We conducted an event history analysis to investigate the effects of previous clinical events on the risk of different endpoints in the total patient group and after stratification by randomization group.

Results
During a median follow-up of 4 years, a total of 548 MACEs occurred, with 469 first and 79 recurrent events. The most frequent event was sudden cardiac death, followed by death due to infection/sepsis. Of the 548 total MACEs, 260 occurred in the atorvastatin group and 288 in the placebo group [hazard ratio 0.91 (95% confidence interval 0.76–1.07), P = .266]. Interestingly, analyses of the baseline hazard functions for first and recurrent events as a function of time after randomization demonstrated that the risks of the composite primary endpoint continually increased in the placebo group with increasing time in the study, whereas the risk in the atorvastatin group remained constant after ≈1.5 years.

Conclusion
This recurrent and total event analysis from the 4D Study underscores the high risk of sudden cardiac death and death due to infection/sepsis in patients with T2DM receiving HD and raises the hypothesis that atorvastatin may stabilize cardiovascular risk only after 1–2 years in this high-risk population.
Comparing directed networks via denoising graphlet distributions
Authors: Silva Miguel E P , Gaunt Robert E , Ospina-Forero Luis , Jay Caroline , House Thomas 
Published: March 2023

AbstractNetwork comparison is a widely used tool for analysing complex systems, with applications in varied domains including comparison of protein interactions or highlighting changes in structure of trade networks. In recent years, a number of network comparison methodologies based on the distribution of graphlets (small connected network subgraphs) have been introduced. In particular, NetEmd has recently achieved state of the art performance in undirected networks. In this work, we propose an extension of NetEmd to directed networks and deal with the significant increase in complexity of graphlet structure in the directed case by denoising through linear projections. Simulation results show that our framework is able to improve on the performance of a simple translation of the undirected NetEmd algorithm to the directed case, especially when networks differ in size and density.
BetweenBacchaeandBahanalii—balkanizing classical reception
Authors: Todorović Nebojša 
Published: March 2023

AbstractThis article sets Euripides’ Bacchae in dialogue with Goran Stefanovski’s Bahanalii, a play that was performed in the immediate aftermath of Yugoslavia’s break-up. Contrapuntal reading shows how the two plays problematize conservative epistemologies by imagining their borderlands as privileged sites of knowledge production. Euripides’ Bacchae opens with a Dionysus who arrives on stage from a faraway land where Greeks and non-Greeks live mixed together. My reading of this passage challenges Edward Said’s interpretation of the Bacchae as a play about the dangers of ‘what lies beyond familiar borders’. Instead, the Bacchae performs an exercise in literary imagination in which a border-minded worldview responds to Athens’ dwindling geopolitical prestige, resists narratives of Greek exceptionalism inherited in the aftermath of the Persian wars, and foresees a return to a kind of Hellenic balkanization avant la lettre. In Bahanalii, Stefanovski resists idealizing mindsets by staging a contradictory Dionis, one that focalizes the epistemological power of the border, while also embodying the uncanny poltergeist of the violence that plagued Yugoslavia in the 1990s. In juxtaposing the narratives of Yugoslav and ancient Athenian exceptionalism, this comparison unlocks a ‘balkanizing’ paradigm of classical reception which complements and complicates existing theoretical accounts of classical reception.