bluuebunny/crossref_metadata_2025_split huggingface dataset:
WITHDRAWN: Effects of Artemisinin on Antiepileptogenic, Antioxidant and Cholinesterase Enzymes in Pentylenetetrazole-induced Kindling Model in Mice.
Authors: Kocak Yilmaz , Yunusoglu Oruc , Huyut Zubeyir , Turkan Fikret 
Published: February 2023

Abstract
Artemisinin (ART) is a compound synthesized from the plant Artemisia annua. This compound has various therapeutic effects and is widely used against malaria. However, ART is known to have modulating effects on GABA (gamma-aminobutyric acid) receptors, which are thought to be responsible for epileptic seizures. This study aimed to evaluate the effects of ART on anti-convulsant, antioxidant, and cholinesterase enzyme activities in pentylenetetrazole (PTZ)-induced kindling model in mice. In the experiment, 6 groups were formed, with seven mice in each group. Mice received a total of 11 intraperitoneal injections of PTZ (35 mg/kg). On the last day of the study, a threat dose of PTZ (75 mg/kg) was administered. In addition, behavioral analysis tests (Locomotor activity and rotarod) and biochemical measurements were performed. Compared with the PTZ group, ART attenuated the severity of the kindling, decreasing the seizure score. ART and VPA reversed increased oxidative stress. Decreased cholinesterase enzymes in PTZ-induced brain increased with ART treatment. While the PTZ application impaired locomotor activity in mice, the ART application provided improvement in locomotor activity. However, no significant difference was found between the groups in the motor performance of the mice. The findings show that ART may have the potential to prevent PTZ-induced oxidative stress, neurochemical changes, behavioral disorders, and seizures.
Detrimental effects of PCSK9 loss-of-function in the pediatric host response to sepsis are mediated through independent influence on Angiopoietin-1
Authors: Atreya Mihir R. , Cvijanovich Natalie Z. , Fitzgerald Julie C. , Weiss Scott L. , Bigham Michael T. , Jain Parag N. , Schwarz Adam J. , Lutfi Riad , Nowak Jeffrey , Allen Geoffrey L. , Thomas Neal J. , Grunwell Jocelyn R. , Baines Torrey , Quasney Michael , Haileselassie Bereketeab , Alder Matthew N. , Lahni Patrick , Ripberger Scarlett , Ekunwe Adesuwa , Campbell Kyle R. , Walley Keith R. , Standage Stephen W. 
Published: February 2023

Abstract
Background: Sepsis is associated with significant mortality, yet there are no efficacious therapies beyond antibiotics and supportive care. In adult sepsis studies, PCSK9 loss-of-function (LOF) and inhibition has shown therapeutic promise, likely through enhanced low-density lipoprotein receptor (LDLR) mediated endotoxin clearance. In contrast, we previously demonstrated higher mortality in septic juvenile hosts with PCSK9 LOF. In addition to direct influence on serum lipoprotein levels, PCSK9 likely exerts pleiotropic effects on vascular endothelium. Both mechanisms may influence sepsis outcomes. We sought to test the influence of PCSK9 LOF genotype on endothelial dysfunction in pediatric sepsis.
Methods: Secondary analyses of a prospective observational cohort of pediatric septic shock. Single nucleotide polymorphisms of PCSK9 and LDLR genes were assessed. Serum PCSK9, lipoprotein, and endothelial marker concentrations were measured. Multivariable linear regression tested the influence of PCSK9 LOF genotype on endothelial markers, adjusted for age, complicated course, and low- and high-density lipoproteins (LDL and HDL). Causal mediation analyses assessed impact of select endothelial markers on the association between PCSK9 LOF genotype and mortality. Juvenile Pcsk9 null and wildtype mice were subject to cecal slurry sepsis and endothelial markers were quantified.
Results: 474 patients were included. PCSK9 LOF was associated with several markers of endothelial dysfunction, with strengthening of associations after exclusion of patients homozygous for the rs688 LDLR variant that renders it insensitive to PCSK9. Serum PCSK9 levels did not correlate with endothelial dysfunction. PCSK9LOF significantly influenced concentrations of Angiopoietin-1 (Angpt-1) and Vascular Cell Adhesion Molecule-1 (VCAM-1). However, upon adjusting for LDL and HDL, PCSK9LOF remained significantly associated with low Angpt-1 alone. Causal Mediation Analysis demonstrated that the effect of PCSK9 LOF on mortality was partially mediated by Angpt-1 (p=0.0008). Murine data corroborated these results with lower Angpt-1 and higher soluble thrombomodulin among knockout mice with sepsis relative to the wildtype.
Conclusions: PCSK9 LOF independently influences serum Angpt-1 levels in pediatric septic shock. Angpt-1 likely contributes mechanistically to the effect of PCSK9 LOF on mortality in juvenile hosts. Mechanistic studies on the role of PCSK9-LDLR pathway on vascular homeostasis may lead to the development of novel pediatric-specific sepsis therapies.
Hybrid Modeling of a Multidimensional Coupled Nonlinear System With Integration of Hamiltonian Mechanics
Authors: Abbasi Amirhassan , Kambali Prashant N. , Nataraj C 
Published: February 2023

Abstract
This study concerns hybrid modeling of a multidimensional coupled nonlinear system. The underlying basis for the model is derived from Hamiltonian mechanics capitalizing on the broad utility and efficiency of energy-based reasoning in modeling high-dimensional systems. The hybrid model is essentially an artificial neural network with a computational graph that is modified from conventional neural networks in a few significant ways. The first modification includes incorporating an intermediate scalar function representing the Hamiltonian learned from data. The second modification enhances input/output channels for capturing the multidimensional dynamics of the system. The main goal of such hybrid reasoning is to improve the extrapolation capability of the model by enforcing conformance with some key aspects of the underlying physics in the form of a bias. The results demonstrate that incorporating this physics-based bias into the hybrid model empowers it to produce long-term and physically plausible predictions. The proposed modeling approach also shows high scalability for energy-based modeling of multidimensional dynamic systems in general.
A Study of Perceived Ease of Use, Perceived Usefulness and Self-Efficacy Among Mature-Aged Worker's Behavioural Intention on Using the Online Training Portal in Manufacturing Industry
Authors: Mokmin Nur Azlina Mohamed , Neoh Yong Ting 
Published: February 2023

Abstract
Online training portal such as e-learning enables corporates and industries to train their
employees so that they can upgrade their skills and knowledge to compete in the global
market. Mature-aged workers, aged between 45 and above, are deemed as valuable assets to
the organizations as they have years of experience and have great potential to guide younger
employees. Human Capital Report August 2019 by HRDF showed that mature-aged workers
with the age of 45 and above have a training participation rate below 20%. As such, these workers have challenges in using the computer and assessing online training portals. Therefore, this study seeks to examine the relationship between perceived ease of use, perceived usefulness, and self-efficacy towards their behavioural intention in using online training portals for learning purposes. A quantitative research survey was adapted to analyze the data gathered from 49 workers who have responded, out of 157 manufacturing technicians, to answer the questionnaire that consists of 28 questions. The research findings show all variables, such as perceived ease of use, perceived usefulness, and self-efficacy have a relationship with mature-aged workers' behavioral intention to use online training portals for their learning.
Analysis of the differential expression and antiviral activity of porcine interferon-α in vitro
Authors: Fang Jianyu , Zhang Qingxian , Xi Yanyan , Lang Limin , Wang Keling , Li Shaoyu 
Published: February 2023

Abstract
Porcine interferon α (poIFN-α) is a crucial cytokine that can prevent and treat viral infection. Seventeen functional porcine IFN-α subtypes were found in the porcine genome. In this study, multiple sequence alignment was performed to analyze IFN-α protein structure and function. Phylogenetic tree analysis of the porcine IFN gene family defined the evolutionary relationship of the various subtypes. Porcine IFN-αs, including porcine IFN-α1–17, were expressed in an E. coli expression system. The antiviral activities of these IFN-α proteins against vesicular stomatitis virus (VSV) and pseudorabies virus (PRV) were examined in PK-15 cells. We found that the antiviral activity of different porcine IFN-α molecules greatly differed: the porcine IFN-α14 and 17 subtypes had the greatest antiviral activities against VSV and PRV in PK-15 cells, porcine IFN-α1, 2, 3, and 8 exhibited lower biological activities, and porcine IFN-α4, 5, 6,7, 9, 10, 11, 12, 13, and 16 had minimal or no effect in the tested target cell‒virus systems. Moreover, our studies demonstrated that the antiviral activity of IFN-α was positively correlated with the induction of IFN-stimulated genes, such as 2’-5’ oligoadenylate synthetase 1 (OSA1), interferon-stimulated gene 15 (ISG15), myxoma resistance protein 1 (Mx1), and Protein kinase R (PKR). Thus, our experimental results provide important information for understanding the antiviral functions and mechanism of porcine IFN-α.
Comparative studies of Electromagnetic and Geoelectrical methods to estimate the porosity and specific yield of karst aquifer, West of Iran
Authors: Fasihi Rojin , Tizro A. Taheri , Marofi S. , Voudouris Kostas 
Published: February 2023

Abstract

Knowledge of aquifer parameters is essential for managing groundwater resources. Parameters such as porosity and specific yield are among the basic features to describe the hydrogeological conditions of a region. In this research, the Electromagnetic method is compared with Geoelectrical soundings. Data collection was made available by field reconnaissance visit and is used to investigate and estimate the values of porosity and specific yield of the karst aquifer feeding 5 springs: Famaseb (Sp1), Faresban (Sp2), Gian (Sp3), Ghale Baroodab (Sp4), and Gonbad kabood (Sp5). All these springs are located in the Nahavand Plain, Hamadan Province, west of Iran. Fifteen (15) soundings were obtained upstream of each spring and were used to analyze the results, quantitative and qualitative interpretation of geoelectrical data, logs of subsurface layers, and ranges of apparent resistivities and their electromagnetic frequencies were determined. The value of apparent resistivity was calculated for the saturated and unsaturated layer of each spring, the results were compared with electromagnetic frequencies, which showed that the results of the two methods used were almost similar. The porosity and specific yield by using Archie's law were calculated. It is found that the Faresban spring (Sp2) has maximum porosity of 55% and a specific yield of 0.48 and in contrast to the lowest value of parameters mentioned in the Ghale Baroodab spring (Sp3, porosity 26% and specific yield 0.18). All the estimated values are compatible with the discharge of springs measured in the field and consistent with the geological conditions of the study area.
Application of nano SiO 2 -IPBC microcapsules in the anti-mildew and UV- resistance of rubber wood
Authors: Xu Guoqi , Li Jiaqi , Qin Shaoshan 
Published: February 2023

Abstract
Recent advances addressing the development of anti-mildew and UV-resistance microcapsules for wood. IPBC is enclosed in the drug-loaded carriers, through slow release, resulting in the anti-mildew process. Anti-mildew experiments showed that the control effectiveness of 1.25wt% nano SiO2-IPBC microcapsules was 78.125% against Botryodiplodia theobromae. In addition, a novel angle of view is discussed, which is the UV-resistance, including different mass fraction of nano SiO2-IPBC microcapsules, IPBC and the control group. Different FTIR characterizations and surface color related to impregnated wood samples are discussed. Nano SiO2-IPBC microcapsules had better bonding performance and UV-resistance than IPBC due to the synergistic effect of nano SiO2 and IPBC in the microcapsules. Color measurements showed that the UV-resistance of microcapsules was better than 1.25wt% IPBC impregnated wood samples.
It helps us open new horizons to anti-mould agent, which offers multi-function of great anti-mildew effect and excellent UV-resistance. The simple and green method for the preparation of microcapsules would have tremendous potential for the extensive development of wood protection.
Improving the COI DNA barcoding library for Neotropical phlebotomine sand flies (Diptera, Psychodidae)
Authors: Posada-López Laura ,   Bruno Leite Rodrigues2, Velez Ivan Dario , Uribe Sandra 
Published: February 2023

Abstract

Background: Sand fly species are traditionally identified using morphological traits, thought this method is hampered by the presence of cryptic species. DNA barcoding is a widely used tool in the case of insects of medical importance, where it is necessary to know quickly which species are present in a transmission area. Here, we assess the usefulness of COI DNA barcoding as a practical tool for species identification, correct assignment of isomorphic females, and to evaluate the detection of cryptic diversity that occurs in the same species.
Results: A fragment of the mitochondrial cytochrome c oxidase subunit I (COI) gene was used to generate 156 new barcode sequences for sand flies from different countries of the Neotropical region, mainly Colombia, which had been identified morphologically as 43 species. The sequencing of the COI gene allowed the detection of cryptic diversity within species and correctly associated isomorphic females with males identified by morphology. The maximum intraspecific genetic distances ranged from 0 to 8.32% and 0 to 8.92% using uncorrected p distances and the K2P model, respectively. The minimum interspecific distance (nearest neighbor) for each species ranged from 1.5 to 14.14% and 1.51 to 15.7% using p and K2P distances, respectively. Three species had more than 3% maximum intraspecific distance: Psychodopygus panamensis, Micropygomyia cayennensis cayennensis, and Pintomyia evansi. They also were splitted into at least two MOTUs each, using different species delimitation algorithms. Regarding interspecific genetic distances, the species of the genera Nyssomyia and Trichophoromyia generated values lower than 3% (except Ny. ylephiletor and Ny. trapidoi). However, the maximum intraspecific distances did not exceed these values, indicating the presence of a barcode gap despite their proximity. Also, nine sand fly species were DNA barcoded for the first time: Evandromyia georgii, Lutzomyia sherlocki, Ny. ylephiletor, Ny. yuilli pajoti, Psathyromyia punctigeniculata, Sciopemyia preclara, Trichopygomyia triramula, Trichophoromyia howardi, and Th. velezbernali.
Conclusions: The COI DNA barcode analysis allowed the correct delimitation of several Neotropical sand fly species from South and Central America and raised questions about the presence of cryptic species for some taxa, which should be further assessed.
System Design for the Detection of Induction Motor Faults using Multi-Domain Feature Fusion
Authors: USMAN Adil , AZIZ Sumair , KHAN Muhammad Umar 
Published: February 2023

Abstract
Accurate and early detection of the bearing faults would make it possible to solve the problem at a lower cost by replacing relevant parts. In this article, a machine learning technique has been proposed for the detection of inner-race and outer-race bearing faults of the motor. A test bench is developed for experimentation in which easy insertion and removal of the faulty and healthy bearing of an induction motor is possible. A vibration sensor was employed to diagnose the motor faults. A dataset of 3-dimensional vibration signals is acquired from the motor representing inner-race and outer-race bearing faults. Vibrational signal data is pre-processed using empirical mode decomposition (EMD) to decompose the raw signals into its integral components called Intrinsic Mode Functions (IMFs) and to find the region of interest. A new scheme for the selection of discriminated features in bearing fault detection application is presented here in which firstly, Multi-domain features were extracted from pre-processed, and were serially fused. Then, Principle Component Analysis (PCA) technique was employed for the reduction of feature vector dimension which resulted a set of only ten features. The proposed features have positive repercussions on the performance of various existing classifiers used in motor bearing fault detection applications. However, Support Vector Machine with a linear kernel (SVM-L) is proposed to recognize the healthy, inner-race fault and outer-race fault states of the motor bearing due to its linear basis. The results of extensive experimentation appreciate the performance of the proposed technique.
Vortex induced sound prediction of slat noise from time-resolved particle image velocimetry data
Authors: Seo Jung Hee , Zhang Yang , Mittal Rajat , Cattafesta Louis N. 
Published: February 2023

Abstract
A data-driven method for predicting the vortex induced sound from time-resolved velocimetry data is presented and applied to the sound generated by flow passing through the slat in a multi-element high-lift airfoil. The time dependent velocity fields in the slat-cove region of the 30P30N multi-element airfoil are obtained from time-resolved particle image velocimetry measurements, and a low-order reconstruction is achieved by using the rank-one vbnm modes from spectral proper orthogonal decomposition. The pressure force and associated dipole sound are then computed via the application of the force and acoustic partitioning methods (Seo et al., Physics of Fluids 2022) which involve volume integrals of the product of the second invariant of the velocity gradient tensor and geometry dependent influence fields. The method enables estimation of the dipole sound generated by local flow structures, and the results are shown to be consistent with theory of vortex sound. Comparison with the measured sound data suggests that while the shear layer modes are responsible for the tonal noise, the interactions between the shear layer modes and other parts of the wing also generate a substantial level of flow noise.
Optimizing the energetic landscape for SiOx/LiNi0.5Mn1.5O4 battery
Authors: Ko Seongjae , Han Xiao , Shimada Tatau , Takenaka Norio , Yamada Yuki , Yamada Atsuo 
Published: February 2023

Abstract
In the world’s transition to a sustainable society, it is urgent to develop an electrochemical energy storage system that can simultaneously satisfy several social requirements, including high energy density, low cost, environmental friendliness, and elemental abundance. In this context, many researchers have attempted to realize an ideal battery, combined with SiOx (high-capacity and earth-abundant) anode and LiNi0.5Mn1.5O4 (high-voltage & Co-free) cathode. However, its stable operation is yet to be achieved because the reaction potentials of SiOx and LiNi0.5Mn1.5O4 are located outside the thermodynamic potential window of the traditional electrolytes. In addition, the huge volume change of SiOx easily deforms the belatedly formed passivation film. Herein, we report a long-awaited extremely stable SiOx|LiNi0.5Mn1.5O4 battery with an upper cut-off voltage of 4.9 V is successfully achieved by optimizing its overall energetic landscape. The design rationales include (i) upshifting the reaction potential of the SiOx anode closer to the reduction limit of the electrolyte, (ii) formation of a robust anion-derived passivation film on the SiOx anode surface at a higher potential prior to its huge expansion, (iii) tuning the redox potential of LiNi0.5Mn1.5O4 into the electrolyte stable window, and (iv) suppression of oxidative degradation, including Al corrosion and transition metal dissolution.
Effect of Microsprinkler Irrigation and Nutrient Management on Growth, Yield, Water Use Efficiency and Macronutrient Accumulation of Large Cardamom in Sub-Himalayan Region of India
Authors: Lepcha R. , Patra S. K. , Ray R. , Thapa S. , Baral D. 
Published: February 2023

Abstract

Optimum water and nutrient coupling are the primary requirements for sustainable plant production. A field experiment designed with three tiers of irrigation i.e., I0: rainfed, I1: 1.0 crop evapotranspiration (1.0 ) and I2: 0.75 and four tiers of nutrition i.e., N0: control (no manure and fertilizer), N1: 100% recommended dose of fertilizer (RDF) as FYM, N2: 50% RDF as FYM + 50% RDF as chemical fertilizers and N3: 100% RDF as chemical fertilizers was conducted for four consecutive years (2015-2018) on large cardamom in a hilly terrain of sub-Himalayan region in India. The results showed that microsprinkler irrigation at 1.0 along with full dose of chemical fertilizers (20:40:40::N:P2O5:K2O kg ha-1) recorded the highest growth, yield attributes, fresh (665.22 kg ha-1) and dry (282.03 kg ha-1) capsule yields, the greatest water use efficiency (0.18 kg ha-1mm-1) and the largest soil availability and plant leaf accumulation of N, P and K. The soil water contents increased with incremental soil depth and irrigation regime, and continued to rise up to flowering stage, sharply dropped at capsule development stage and further increased at maturity stage. The predictive regressive models showed the linear relationships between the dry capsule yield and irrigation water and total water use.
The Experience of Psychiatry Residents with Individual Supervision in an ACGME-I Accredited Program in Qatar
Authors: Makki Ibrahim , Ouanes Sami , Carpio Shane Atienza , Ghuloum Suhaila 
Published: February 2023

Abstract
Background
The policies on resident supervision in the psychiatry training program at Hamad Medical Corporation (HMC), Qatar, meet the requirements of the Accreditation Council of Graduate Medical Education-International (ACGME-I). The psychiatry department has mandated one-hour weekly supervision of residents. Unlike clinical supervision, little is known about how residents perceive individual supervision and its impact on their training. The purpose of this study was to explore psychiatry residents’ feedback on weekly individual supervision, focusing on frequency, content, and perceived quality.
Results
We conducted an anonymous survey among all residents in the psychiatry department of HMC, exploring the number and content of individual supervision sessions received during the previous six months, and their satisfaction with supervision provided.
Out of 25 residents, 20 responded to the survey. The results showed that 95% (n=19) of those who responded had received some form of supervision during the previous six-month period, 15% (n=3) had it consistently on a weekly basis, and only 5% (n=1) received no supervision at all. “Topics selected by the resident and/or the supervisor” was the most frequently provided response by the residents to highlight the content of supervision. The percentage of residents satisfied was proportional to the number of individual supervision sessions received.
Conclusions
Action must be taken to improve the standard of individual supervision to include training of faculty, time protection during supervision, and ongoing support from program leadership.