bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adamantinoma-like Ewing Sarcoma Arising in the Abdominal Cavity: A Case Report of a Rare Entity and Review of the Literature
Authors: WANG ZHE , ZHANG XINKE , ZHANG YINGCHUN , WEN XIAOBO 
Published: May 2023

Abstract
ALES is a rare subtype that demonstrates the EWSR1-FLI1 translocation characteristic of ES and demonstrates complex epithelial differentiation including diffuse cytokeratin and p40 expression. It has predominantly recognized in the head and neck and is common in middle-aged population. This case is the first case of ALES reported in the abdominal cavity, sharing some morphological characteristics with ALES in the head and neck, including monotonous cytology, infiltrative growth pattern, and complex epithelioid differentiation, but ALES in the head and neck often has high-grade histological features (e.g., necrosis, high mitotic rate, etc.), and sudden keratinization can also occur, but these features were not reflected in this primary abdominal cavity ALES. Although ALES arising in the abdominal cavity and in the head and neck sites share the immunohistochemical and molecular profile, our case can provide new ideas in differential diagnosis of ALES arising in abdominal cavity and promote increased recognition and understanding of ALES.
Diagnostic value of contrast-enhanced ultrasound in preoperative evaluation of lymph node metastasis and thyroid nodules in papillary thyroid carcinoma: a single-center retrospective study
Authors: Yang Zhixin , Wang Xiaofeng , Tao Tao , Zou Jiali , Qiu Zhu , Wang Long , Du Huimin , Chen Ni , Yin Xuedong 
Published: May 2023

Abstract
Background
The contrast-enhanced ultrasound (CEUS) has been recently used for the assessment of cervical lymph node metastasis to guide the surgical operation in the patient with papillary thyroid carcinoma (PTC). However, the specificity and sensitivity of CEUS reported from previous studies is not consistent. The objective of this study was to evaluate the diagnostic value of CEUS to the metastasis of cervical lymph node in PTC patients based on the data from one regional central hospital.
Methods
The diagnostic value of CEUS in preoperative LNM of PTC patients was concluded by comparing the results of CEUS on lymph node status with postoperative pathology examination. In addition, this study conducted hierarchical analysis of PTC patients to explore whether tumor size, different lymph node regions, and hashimoto's thyroiditis have an influence on the assessment of CEUS.
Results
This research enrolled 965 PTC patients finally, including 266 male and 699 female patients with a mean age of 42.27±11.34 years. 527 patients were supposed to be clinical-node negative and 438 were clinical-node positive before surgery. The specificity, sensitivity, PPV, NPV and accuracy of CEUS in the assessment of LNM in PTC patients were 56.00%, 71.00%, 57.06%, 69.76% and 62.59% respectively. For central and lateral lymph node, the accuracy of CEUS in PTC patients were 49.43% and 54.30%, respectively. Besides, it was showed that the accuracy of CEUS in PTC patients with HT slightly dropped to 58.44%, and the accuracy of CEUS in PTC patients with non-HT in turns increased to 64.17%. The accuracy of CEUS in non-PTMC and PTMC patients were 65.68% and 61.24%, respectively. The accuracy of CEUS in predicting central lymph node metastases was statistically different in PTC patients with or without Hashimoto's thyroiditis(P＜0.001) in this study, but not in lateral lymph nodes (P=0.114).
Conclusion
The accuracy of CEUS on the assessment of LNM in PTC is not consistently satisfactory, especially for central lymph nodes, small tumor diameter, or the patient with HT. More diagnostic technologies for abnormal lymph node should be considered in PTC patients.
Vacuoles and peroxisomes are involved in Aspergillus fumigatus
gliotoxin production and self-protection
Authors: de Castro Patrícia , Pinzan Camila , Reis Thaila does , Valero Clara , Rhijn Norman van , Menegatti Carla Carla , Migliorini Ivan , Bromley Michael , Trentin Gabriel , Almeida Fausto , Fleming Alastair , Traynor Aimee , Sarikaya-Bayram Özlem , Bayram Ozgur , Malavazi Iran , Ebel Frank , Barbosa Júlio , Fill Taícia , Pupo Monica , Goldman Gustavo 
Published: May 2023

Abstract
Aspergillus fumigatus is a saprophytic fungus that can cause a variety of human diseases known as aspergillosis. Mycotoxin gliotoxin (GT) production is important for its virulence and must be tightly regulated to avoid excess production and toxicity to the fungus. GT self-protection by GliT oxidoreductase and GtmA methyltransferase activities is related to the subcellular localization of these enzymes and how GT can be sequestered from the cytoplasm to avoid increased cell damage. Here, we show that GliT:GFP and GtmA:GFP are localized in the cytoplasm and in vacuoles during GT production. Peroxisomes are also required for proper GT production and self-defense. The Mitogen-Activated Protein (MAP) kinase MpkA is essential for GT production and self-protection, interacts physically with GliT and GtmA and it is necessary for their regulation and subsequent presence in the vacuoles. Our work emphasizes the importance of dynamic compartmentalization of cellular events for GT production and self-defense.
Employees’ Green Brand Love and Green Brand Citizenship Behavior: Perspectives of Social Exchange Theory
Authors: Lei Gang , Kuang Ting Yue , Yang Yi-Chun 
Published: May 2023

Abstract
Previous research suggested that brand love can enhance employees’ brand citizenship behaviors. In addition, organizational culture can serve as a moderator of the relationship between employees’ brand love and brand altruistic behaviors. Applying this concept in organizational green activities, this research aims to examine the relationship between green brand love and green brand citizenship behavior, and the moderator of culture in the restaurant industry, focusing on contact employees’ perspective. We gathered data from first-line personnel in China’s restaurants, this study chosen 7 chain restaurants which have more than one hundred employee, and each were sent 100 questionnaires. Of the 700 questionnaires sent to frontline employees, 512 valid questionnaires were gathered, representing a response rate of 73.1%. Consistent with our predictions, green brand love exerts a positive effect on green brand citizenship behevior, and testing the moderating effects of organizational cultures reveal that clan culture and adhocracy culture can strengthen the relationship between green brand love and green brand citizenship behavior.
Racial Discrimination is Associated with Binge-Eating Disorder in Early Adolescents: A Cross-Sectional Analysis
Authors: Raney Julia H , Al-shoaibi Abubakr A , Shao Iris Y. , Ganson Kyle T , Testa Alexander , Jackson Dylan B. , He Jinbo , Glidden David V. , Nagata Jason M. 
Published: May 2023

Abstract
Background
Racial and ethnic discrimination are known stressors and are associated with negative psychological and physical health outcomes. Previous studies have found relationships between racial/ethnic discrimination and binge-eating disorder (BED), though they have mainly focused on adult populations. The aim of this study was to determine associations between racial/ethnic discrimination and BED in a large, national cohort study of early adolescents. We further sought to explore associations between the racial/ethnic discrimination perpetrator (students, teachers, or other adults) and BED.
Methods
We analyzed cross-sectional data from the Adolescent Brain Cognitive Development Study (ABCD) (N = 11,075, 2018–2020). Logistic regression analyses examined associations between self-reported racial or ethnic discrimination and binge-eating behaviors and diagnosis. Racial/ethnic discrimination measures were assessed based on the Perceived Discrimination Scale, which measures experiences of discrimination based on race/ethnicity and frequency of ethnic discrimination by teachers, adults outside of school, and students. Binge-eating behaviors and diagnosis were based on the Kiddie Schedule for Affective Disorders and Schizophrenia (KSAD-5), adjusting for age, sex, race/ethnicity, household income, parental education, and site.
Results
In this racially diverse sample of adolescents (N = 11,075, mean age: 11 years), 4.7% of adolescents reported racial or ethnic discrimination and 1.1% met the criteria for BED at the one-year follow-up. In the adjusted models, racial/ethnic discrimination was associated with 3 times higher odds of having BED (OR 3.31, CI 1.66–7.74); when investigating associations between the racial/ethnic discrimination perpetrator (students, teachers, or other adults) and BED, experiencing ethnic discrimination by students and adults outside school were associated with significantly increased odds of BED diagnosis (OR 1.36, CI 1.10–1.68 & OR 1.42 CI 1.06–1.90, respectively); further, increased odds of binge eating behaviors was only significantly associated with ethnic discrimination perpetuated by students (OR 1.12, CI 1.02–1.23).
Conclusions
Children and adolescents who have experienced racial/ethnic discrimination, particularly when discrimination was perpetuated by other students, have higher odds of having binge-eating behaviors and diagnoses. Clinicians may consider screening for racial discrimination and providing anti-racist, trauma-informed care when evaluating and treating patients for BED.
A Facile Environ-friendly One-pot Water-promoted Synthesis of Bis 1,2,3-triazole Linked Bis 2 - Aminopyrimidine Hybrids
Authors: Maheswari Rasupillai Murugesan , Ponnuswamy Alagusundaram 
Published: May 2023

Abstract
An elegant and efficient synthesis of a series of the novel (1,4) bis 1,2,3-triazole fused aminopyrimidine derivatives has been accomplished for the first time in green solvent viz water. Our method does not require chromatographic separation as the pure product is thrown out in the water medium.
Culture identification and antibiogram of Klebsiella pneumoniae isolated from a sputum sample
Authors: Khan Ruby , Wali Saima , Pari Bakht , Amir Nimra 
Published: May 2023

AbstractGram-negative pathogens are an important cause of community and hospital-acquired infections throughout the world. Klebsiella pneumoniae has become one of the more common causes of these infections and one of the important aspects of Klebsiella associated infections. It is the emergence of multi-drug resistant strains particularly those involved in nosocomial diseases. This study was done to determine the isolation rate of Klebsiella, their antibiogram and for the presence of resistant strains from sputum samples. A total number of 16 sputum samples were included in the present study. Sixteen clinical isolates were collected from Mardan Medical Complex ,Khyber Pakhtunkhwa, Pakistan.Klebsiellawere identified by standard microbiological techniques and antibiotic susceptibility testing was done by Kirby-Bauer disc diffusion method and interpreted as per CLSI guidelines. Through KBDD (Kirby Bauer Disk Diffusion Method), four verifiedK.pneumoniaeisolates were subjected to further testing for antimicrobial drug sensitivity. It was discovered that roughly 50% of them were multidrug resistant. As per CLSI guidelines results of the present study revealed that confirmedK.pneumoniaeisolates were resistant to Vancomycin 30(µg) , Amikacin 30(µg), Chloramphenicol 30(µg), Amoxicillin 30(µg) , Ticarcillin 75(µg) and were susceptible to Meropenem 10(µg),Piperacillin 100(µg) and Tazobactam 110(µg). These are capable of acting as an effective antibacterial agent in the treatment of serious bacterial infections caused byK. pneumoniae. The present study reveals the isolation ofKlebsiellafrom sputum samples and their tendency towards antibiotic resistance.K. pneumoniawas found to be most sensitive to Meropenem 10(µg), Piperacillin 100(µg) and Tazobactam 110(µg). The data of this study may be used to determine trends in antimicrobial susceptibilities to formulate local antibiotic policies and overall to assist clinicians in the rational choice of antibiotic therapy.
Changes in inner retina thickness and macular sensitivity in diabetic 2 patients with moderate diabetic retinopathy
Authors: Boned Ana , Fernandez Guisela , Orduna Elvira , Diaz Maria Dolores , Sanchez Ana Isabel , Sopeña Maria , Bielsa Sofia , Pinilla Isabel 
Published: May 2023

Abstract
To analyze total retinal(RT) and inner retinal layers(IRL) thicknesses in type 2 diabetes mellitus (DM2) patients and retinal sensitivity, using swept source OCT(SS-OCT), and microperimetry. A total of 54 DM2 subjects with moderate diabetic retinopathy(DR) with no signs of diabetic macular edema(DME) and 73 age-matched healthy individuals were assessed by SS-OCT to quantify retinal thickness in the nine macular areas of the ETDRS grid. Retinal sensitivity was measured by microperimetry with MAIA. Mean ages were 64.06 ± 11.98 for the DM2 group and 60.79 ± 8.62 years for the control group. DM2 patients presented lower visual acuity (p < 0.001) and thicker RT (260.70 ± 19.22µm in the control group vs. 271.90 ± 37.61 µm in the DM2 group, p = 0.01). Retinal nerve fiber layer (RNFL) was significantly lower in the outer nasal area (50.38 ± 8.20µm vs 45.17 ± 11.25µm, p = 0.005) as ganglion cells and inner plexiform layers(GCL+) in DM2. A positive correlation between LDL-C and RNFL and a negative correlation between HDL-C levels and inner temporal and central RNFL thickness were detected. The central and inner nasal areas presented a negative correlation between RNFL (p = 0.015) and MAIA (p = 0.008), while the outer inferior area showed a positive correlation(p = 0.025). Retinal sensitivity and macular RNFL thickness decrease in DM2 with moderate DR with no DME.
Machine Learning Decision Support Systems for Predicting Acute Kidney Injury: Improving Precision to improve patient outcomes
Authors: Rahimi Amir Kamel , Ghadimi Moji , Canfell Oliver J. , Pole Jason D. , Sullivan Clair , Shrapnel Sally 
Published: May 2023

Abstract
Background
There are many machine learning (ML) models which predict acute kidney injury (AKI) for hospitalised patients. While a primary goal of these models is to support clinicians with better decision-making in hospitals, the adoption of different methods of estimating baseline serum creatinine (sCr) can result in establishing inconsistent ground truth when estimating AKI incidence. The real-world utility of such models is therefore often an issue given the high rate of false positive predictions which can result in negative clinical outcomes.
Objective
The first aim of this study was to develop and assess the performance of ML models using three different methods of estimating baseline sCr. The second aim was to conduct an error analysis to reduce the rate of false positives.
Materials and Methods
For both aims, the Intensive Care Unit (ICU) patients of the Medical Information Mart for Intensive Care (MIMIC)-IV dataset with the KDIGO (Kidney Disease Improving Global Outcome) definition was used to identify AKI episodes using three different methods of estimating baseline sCr. ML models were developed for each cohort and the performance of the models was compared. Explainability methods were used to analyse the XGBoost errors.
Results
The baseline, defined as the mean of sCr in 180 to 7 days prior to ICU, yielded the highest performance metrics with the XGBoost model. Using the explainability methods, the mean of sCr in 180 to 0 days pre-ICU led to a further reduction in FP rate, with the highest AUC of 0.86, recall of 0.61, precision of 0.56 and f1 score of 0.58. The cohort size was 31,586 admissions, of which 5,473 (17.32%) had AKI.
Conclusion
To enable the effective use of AI in AKI prediction and management, a clinically relevant and widely applicable standard method for baseline sCr is needed. In healthcare, the utilisation of explainability techniques can aid AI developers and end users in comprehending how AI models are making predictions. We concluded that ML development with model-driven and data-driven architectures can be effective in minimizing the occurrence of false positives. This can augment the success rate of ML implementation in routine care.
Preferred and actual places of death among patients with advanced cancer: A single-center cohort study in Japan
Authors: Ikari Tomoo , Hiratsuka Yusuke , Oishi Takayuki , Miyashita Mitsunori , Morita Tatsuya , Mack Jennifer W , Okada Yoshinari , Chiba Natsuko , Ishioka Chikashi , Inoue Akira 
Published: May 2023

Abstract
Purpose:
Achieving “good death” is one of the important goals of palliative care. Providing goal-concordant care and an environment tailored to the patient's preferences can contribute to “good death.” However, the concordance rate between the preferred and actual places of death among advanced cancer patients in Japan is less explored. This study aimed to identify the concordance between patients’ preferred and actual places of death, and the associated factors among patients with advanced cancer in Japan.
Methods:
Patients with advanced cancer who underwent chemotherapy between January 2015 and January 2016 were enrolled and followed up for 5 years. The enrolled patients were asked about their preference for their place of death. The response options were: “Own home,” “General ward” and “Palliative care unit (PCU).” We compared the actual place of death with the patient’s preference through a follow-up review of the medical records.
Results:
A total of 157 patients with advanced cancer were enrolled between January 2015 and January 2016. Of these patients, 22.9% (11/48) died at home according to their preference, 64.0% (16/25) in the general ward, and 37.9% (11/29) in the PCU. Only thirty-seven (37.3%) patients died where they wanted, based on the comparison between patients' preferences and actual places of death.
Conclusion:
The concordance rate between the preferred and actual places of death is not high in Japan. Improving concordance between patients' preferences and actual places of death has the potential to improve end-of-life care.
The effect of EEG biofeedback on patients with insomnia: an open- label study
Authors: huicong wang , Hou Yue , Wang Hongxing , Zhan Shuqin , Li Ning , Liu Jianghong , Wang Yuping 
Published: May 2023

Abstract
Insomnia is the most prevalent clinical sleep disorder and is usually accompanied by some affective symptoms. As traditional interventions for insomnia have certain limitations, novel interventions such as biofeedback therapy can be of great clinical significance. Here, we aimed to explore the clinical efficacy of biofeedback for insomnia and its potential mechanisms of action. We recruited 82 patients with insomnia from the insomnia clinic at the Xuanwu Hospital. Electroencephalography (EEG) and electromyography (EMG) biofeedback training was conducted for 30 minutes. EEG data of two minutes were also recorded each before and after training. Intervention was performed once every alternate day and included 10 biofeedback treatments session and measured three times before, after fifth, and after tenth biofeedback treatment session. Scores on the Pittsburgh Sleep Quality Index (PSQI) scale after one trial of biofeedback treatment were significantly lower than those before treatment (p < 0.001) and continued to lower after subsequent trials (p < 0.001). Specifically, patients experienced a significant reduction in insomnia, an easier transition to natural sleep, a shorter time to fall asleep, fewer awakenings during sleep, and a much better quality of sleep. Additionally, the scores on the Beck Depression Inventory Scale (BDI) and State-Trait Anxiety Scale (S-STAI, and T-STAI) after treatment were significantly lower than those before treatment (p < 0.001). Our findings suggest that biofeedback therapy is effective in relieving insomnia symptoms for insomnia patients and biofeedback therapy likely relaxes the patients’ minds (reflected by the alpha wave) and muscles (reflected by frontal EMG) and reduces alertness states (reflected by beta waves), which finally promotes deep sleep (reflected by the theta wave).
Point of Care Assessment of Sexual Concerns among AYA Oncology Active Patients and Survivors
Authors: Shi Molin , Meltzer Karen J. , Dunker Alexandra , Hall Brittany C. 
Published: May 2023

Abstract
Purpose
Adolescent and young adults (AYAs) oncology populations have unique sexual health concerns that deserve more attention. The current study aimed to describe the prevalence and characteristics of sexual health and related concerns in AYAs in active treatment and survivorship to move toward integrating sexual health in routine care.
Methods
A total of 127 AYAs (ages 19–39) in active treatment and survivorship were recruited from three outpatient oncology clinics. In addition to providing demographic and clinical information, they completed an adapted version of the NCCN Distress Thermometer and Problem List (AYA-POST; AYA-SPOST) as part of an ongoing needs assessment study.
Results
Over one quarter (27.6%) of the total sample (Mage = 31.96, SD = 5.33) – 31.9% of active treatment, and 21.8% in survivorship – reported at least one sexual health concern (i.e., sexual concern, loss of libido, pain with sex, and unprotected sex). The most frequently endorsed concerns differed between active treatments and survivorship. Both genders often endorsed general sexual concerns and loss of libido.
Conclusion
The literature on sexual concerns in the AYA population is sparse and inconclusive, especially accounting for gender and other types of concerns. The current study highlights the need for further examination between treatment status, psychosexual concerns, emotional distress, and demographic and clinical factors. Given the prevalence of sexual concerns in AYAs in active treatment and survivorship, providers should consider integrating assessment and discussion of these needs at onset of diagnosis and as part of monitoring.
Experimental Investigation on the Grading Optimization and Storage Effect of Crushed Gangue for Backfill
Authors: Sun Kai , Zhu Lei , Li Jian , Tian Shanjun , Yang Zhiqiang , Liu Zhicheng , Wo Xiaofang 
Published: May 2023

Abstract
Coal mine backfilling mining controls the movement of overlying rock and surface subsidence by backfilling the fractured rock mass into the goaf. The compaction mechanical performance of the fractured rock is the key to the effectiveness of overlying rock control. In order to optimize the control effect of crushed gangue overlying rock, this article focuses on the regulating effect of gangue particle size grading on mechanical properties. Through research on the physical properties of gangue and natural graded gangue compaction experiments, the porosity of gangue crushing and the process of gangue crushing are analyzed. It is shown that the gangue material has good load-bearing performance in terms of physical structure, and the elastic modulus has an absolute effect on the compression characteristics of gangue particles. Through storage analysis of the natural grading experiment phenomenon, it was found that the alarm height for gangue not to be blocked is 20m. Through laboratory experiments, the compression characteristics of group B samples were analyzed, and it was found that the particles showed a trend of first increasing and then decreasing under the coupling effect of particle size and particles of different sizes. Through the analysis of particle strain energy density and breakage energy, it is concluded that the strain energy density of the sample from high to low is B1, B2, B6, A5, B5, B4, and the breakage energy consumed to reach the sample broken state from low to high is A5, B6, B5, B4, B3, B2, B1, so the B6 group samples have the best economic benefits. Through analysis from the perspective of filling rate, it was found that the B6 group of samples has the best control effect on the overlying rock. Thus providing suggestions for optimizing the efficiency and effectiveness of backfill mining.