bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinicopathological Study of 307 Patients with Lichen Planus Actinicus and Pigmentosus Referred to Razi Skin Hospital from 2016 to 2021
Authors: Kamyab Kambiz , Gholi Zahra , Ghiasi Maryam , Pirzadeh Marzieh , Nasimi Maryam 
Published: April 2023

Introduction: The two less-known subtypes of lichen planus (LP) are lichen planus actinicus (LPA) and lichen planus pigmentosus (LPP), with the highest prevalence in the Middle East. Objectives: We aimed to evaluate the clinicopathological profile of these patients. Methods: 307 cases including 184 LPA and 123 LPP patients were recruited from the registered pathology reports of Razi Skin Hospital of Tehran from April 2016 to March 2021. The clinical features and pathological reports were extracted and analyzed. Results: Among 307 patients, 117 (63.9%) in the LPA group and 88 (71.5%) in the LPP group were women. Duration of disease ranged from 1 month to 20 years and 1 month to 12 years in the LPA and LPP groups, respectively. Face (159 patients), limbs (68), and neck (23) were the most frequent sites of involvement in LPA patients, whereas face (60 patients), limbs (47), and trunk (42) were more commonly involved in the LPP patients. Pruritus and oral mucosal lesions were found with similar frequency in both groups. Pathological evaluation showed vacuolar degeneration of basal layer (100%), lymphocytes infiltration (97.3%), and melanin incontinence (58.2%) as the most frequent findings in LPA and vacuolar degeneration of basal layer (100%), lymphocytes infiltration (100%), and melanin incontinence (52/8%) as the most frequent findings in LPP cases.Conclusion: LPA and LPP were both more prevalent among women. Face was the most common site of involvement in both LPA and LPP. Vacuolar degeneration, lymphocyte infiltration, melanin incontinence, and hyperkeratosis were more common histological findings in this study.
A Non-interventional Study on Vismodegib for Basal Cell Carcinoma With A Treat-To-Target Regimen In Swedish Patients
Authors: Bendsöe Niels , Paoli John , Söderkvist Karin , Persson Bertil , Halldin Christina , Ihrlund Linda , Wolodarski Maria 
Published: April 2023

Introduction: Real-life data on vismodegib in advanced basal cell carcinoma (aBCC) are limited. Optimal treatment duration is left to the discretion of the physician.
Objectives: To assess the effectiveness, safety and treatment pattern for vismodegib in aBCC in clinical practice.
Methods: In this multicenter, non-interventional, prospective study, 49 Swedish patients planned for vismodegib treatment were included. The treatment pattern observed was treatment until remission, allowing unlimited discontinuations/pauses.
Results: The majority of patients (93.8%), discontinued at least once during the study. Compared to earlier studies there was a decrease of more than 2 months with actual drug intake, reducing the patients burden and costs, at the same time as a high number of responses were seen (87.8%). Median progression-free-survival was 16.7 months, and 90% of the patients were alive at 13.3 months. Ten patients were re-challenged with vismodegib at recurrence or progression, resulting in five partial remissions and three complete remissions.
Conclusions: Clinical response rates with vismodegib for aBCC were similar to those of similar trials despite a shorter and more intermittent treatment duration. The majority of re-challenges lead to partial or complete remissions.
Fundamentals of Agronomy
Authors: Lalitha B.S , Sannagoudar M.S. , Reddy G. 
Published: April 2023

Agronomy is the core subject of agricultural sciences. A strong foundation for agricultural education emerges by understanding the principles of Agronomy. Majority of the Students who join for the degree programmes in agriculture universities are never exposed to the crops and crop production aspects.The beginner’s to agriculture needs to be introduced the meaning, scope and principles of agronomy. With this back ground and keeping in mind the common syllabus prescribed by the Dean’s committee for agriculture education in the country efforts are made to compile and present the information on introduction to agronomy, agriculture, meaning, scope and importance, history of development of agriculture, agricultural education and research in the country and elsewhere, factors affecting plant growth, manures and fertilizers, principles of agronomy viz. soil management, crop management, weed management, management of problematic soils, cropping systems, selection of planting materials, their treatment in simple language. At the end of each chapter subjective and objective questions are provided for practice. The author hopes that this book will be useful for the students for learning and for the faculty for teaching the course “Fundamentals of Agronomy” for the undergraduate degree programme in the Agricultural Universities.
PHÒNG, CHỐNG KHỦNG BỐ SINH HỌC QUA ĐƯỜNG THƯ TÍN
Authors: Phạm Xuân Ninh  
Published: April 2023

Theo ghi nhận của Tổ chức Y tế thế giới, trong vòng 20 năm gần đây, bên cạnh các tác nhân sinh học tối nguy hiểm đã xuất hiện trước đó (như bệnh than, bệnh dịch hạch, bệnh đậu mùa...), người ta đã phát hiện hơn 30 loại tác nhân sinh học mới, có thể gây dịch bệnh hết sức nguy hiểm khác (như vi-rút Nipah, SARS, MERS, SARS-CoV-2…). Những tác nhân này khi xâm nhập vào cơ thể có thể dẫn tới tử vong nếu không được điều trị kịp thời hoặc lây lan nhanh thành dịch bệnh, gây mất sức chiến đấu của những đơn vị quan trọng. Chúng có thể được sử dụng như một loại vũ khí hủy diệt hàng loạt dựa vào đặc tính gây bệnh/truyền bệnh của các vi sinh vật hoặc độc tố do chúng sinh ra. Ngày nay, các phần tử đối lập ở nhiều nước trên thế giới vẫn đang đẩy mạnh các hoạt động khủng bố, trong đó có sử dụng tác nhân sinh học gây bệnh gửi theo đường thư tín (qua bưu điện) nhằm gây tổn hại nặng nề cho đối phương. Do vậy, cần có những biện pháp tăng cường kiểm tra, phát hiện các tác nhân sinh học, phòng chống khủng bố qua đường thư tín, loại trừ mối nguy hiểm, bảo đảm an toàn cho người nhận thư.
Ultrafiltração por gravidade como alternativa para tratamento de água no ponto de uso: uma revisão
Authors: Cartaxo Amanda da Silva Barbosa , Leite Valderi Duarte , Albuquerque Maria Virgínia da Conceição , Rodrigues Roberta Milena Moura , Amorim Jefferson Santos de , Cavalcanti Ingrid Lélis Ricarte 
Published: April 2023

Com a crescente poluição dos reservatórios de água destinados ao abastecimento humano uma grande parcela da população mundial que não dispõem de água tratada estão sujeitos a ingestão de água contaminadas por microrganismos, pesticidas, cianotoxinas, fármacos, desreguladores endocrinos, entre outros contaminates, culminando em graves problemas na saúde humana. Como a maioria da população que não ingere água tratada concentra-se em regiões distantes ou pouco povoadas o abastecimento por parte das companhias de água torna-se inacessiveis, assim as tecnologias de tratamento de água no ponto de uso (POU) mostram-se atraentes e viaveis. Dentre as POU existentes, a ultrafiltração por gravidade vem chamando atenção, pela sua eficiência na remoção de diversos contaminates, necessitando de baixa pressão para funcionamento, pouca manutenção e permitindo a formação do biofilme, atuando na estabilização do fluxo e melhorias na qualidade do permeado. Sendo assim, o presente trabalho busca apresentar a tecnologia de ultrafiltração por gravidade como alternativa para tratamento de água no ponto de uso. A coleta de dados para a presente pesquisa foi realizada a partir do levantamento de estudos em publicações na literatura acadêmica, relacionadas ao tema “Uso de membrana de ultrafiltração por gravidade para tratamento de água no ponto de uso”, compreendendo artigos publicados no período de 2009- 2021. Como base de dados para a pesquisa utilizou-se a Web of Science (WOS), Google acadêmico, Scopos e PubMed. Foram contemplados 127 artigos, no qual 15 foram selecionados, devido sua relevância para pesquisa. Através dessa pesquisa foi possível verificar que o processo de Ultrafiltração por Gravidade apresenta excelentes resultados na remoção de microrganismos e microcontaminantes orgânicos presentes em águas destinadas ao consumo humano. O biofilme formado na membrana também apresenta-se com grande importância, uma vez que melhora consideravelmente a qualidade do permeado através de sua composição biológica. A tecnologia de ultrafiltração por gravidade mostrou-se como uma boa alternativa para tratamento descentralizado da água apresentando-se como alternativa simples, moderna e acessível, destinada principalmente para populações que não ingerem água tratada.
Effect of fire retardants on germination of agricultural seeds
Authors: Souza Adilson Pacheco de , Silva Andréa Carvalho da , Santos Lucas Bartolomeu dos , Ximenes Elen Silma Oliveira Cruz , Nogueira Herculis , Anjos Alison Martins dos , Santos Rafael José Carvalho dos 
Published: April 2023

The occurrence of fires in agricultural areas grown with winter maize has become recurrent in the Central-West region of Brazil, since the harvest occurs in the dry season in the region. Fire retardants can be used as an indirect control of fire; they consisted of chemical products that can remain in the straws or on the soil after the fire extinction. The objective of this work was to evaluate the effect of two short-term fire retardants (Phos-Chek WD881® and Hold Fire®) and a hydrogel (alternative fire retardant) on germination of rice (Oryza sativa), common bean (Phaseolus vulgaris), millet (Pennisetum glaucum), maize (Zea mays), and soybean (Glycine max) seeds. The control treatment consisted of only distilled water. The seed germination percentage and speed index, mean time for germination, and seedling growth (shoot and root length and dry weight) were evaluated. A completely randomized experimental design was used, with 4 replications per treatment; each experimental unit consisted of 100 seeds maintained in germination chambers (30 °C and photoperiod of 12 hours). The effects of the fire retardants and hygroscopic polymer on the seed germination and seedling initial growth were specific, and no significant effect caused by the variations in the concentrations of the fire retardants was found.
Agrobiodiversidade em comunidades quilombolas do Brasil: uma abordagem cienciométrica e perspectivas de estudo
Authors: Gonçalves Janaína Pinheiro , Alves Raynon Joel Monteiro , Martins Ana Cláudia Caldeira Tavares , Andrade Eloisa Helena de Aguiar 
Published: April 2023

Este estudo objetivou realizar uma abordagem cienciométrica sobre as pesquisas de agrobiodiversidade em comunidades quilombolas no Brasil, durante o período de 2000 a 2021, utilizando diferentes bases de dados virtuais. Os dados quantitativos foram analsiados descritivamente e para gerar as perspectivas sobre a temática, com base na cienciometria, utilizou-se a literatura pertinente, que foi analisada qualitativamente. Foram encontradas 39 produções acadêmico-científicas desenvolvidas por autores predominantemente transeuntes, com predomínio de dissertações e artigos, sobretudo, em relação aos quilombolas da região Centro-oeste, vinculados à Universidade de Brasília. A distribuição temporal das publicações listadas foi esparsa durante o período analisado, com predominância a partir de 2018, tendo abordagens sobre a caracterização, mudanças e segurança alimentar no contexto da agrobiodiversidade. Os manuscritos possuem acesso livre ao público, sendo os artigos os mais citados, e inúmeros métodos e técnicas foram utilizados nestas pesquisas. As categorias de uso de plantas abordadas foram a alimentar e a medicinal, com destaque para as famílias Lamiaceae, Asteraceae e Fabaceae. Diante da agrobiodiversidade quilombola no Brasil ainda são mínimos os trabalhos desenvolvidos e divulgados no meio acadêmico-científico, com perspectivas relacionadas ao fomento de projetos e políticas públicas para a conservação ambiental, incremento de conhecimentos tradicionais e de manejo dos recursos no acervo científico, manutenção das comunidades e do modo de vida tradicional, e investimentos em Ciência e Biotecnologia, principalmente em regiões muito ameaçadas por ações antrópicas.
The cultural code "Rimon" in the pictorial semiosis of the Jews of Crimea
Authors: Kotliar Elena Romanovna , Alekseeva Elena Nikolaevna 
Published: April 2023

The subject of the study is the cultural code "Rimon", covering phytomorphic symbolic images in the Jewish pictorial semiosis. The object of the study is the traditional symbolism in the pictorial practice of the Jews of the Crimea. The article uses the methods of semantic and semiotic analysis in deciphering the meanings of plant symbols of the pictorial semiosis of the Jews of the Crimea, the method of analysis of previous studies, the method of synthesis in structuring groups of signs. The authors consider the following aspects of the topic: the codes of the pictorial semiosis of the Jews of the Crimea are designated, their morphology, semantics, key meanings and the main code are substantiated. The phytomorphic Rimon code and its features are considered in detail. The main conclusions of the study are: 1.	As a result of studying the traditional culture of the Jews of the Crimea, five main codes of the Jewish pictorial semiosis were identified, covering the following groups of symbols: skewomorphic (subject), phytomorphic (plant), zoomorphic (animal), numeric. The source of all codes and the generalizing code is the Sefer code (Book). The interrelationships between the codes, four key meanings – Creation, Paradise, Torah persons and Messianic aspirations are revealed. The semantic center of the code system is defined – the Torah and Aron Hakodesh, as a repository of the Torah. 2.	The considered phytomorphic code Rimon is a symbolism of traditional images of plants, the mention of which is found in the Torah, as well as in the Talmud and Midrash. The images of plants in the Jewish reading convey the meanings of human virtues and negative qualities, and also indicate the Messianic hopes laid down in the Torah and especially in the Midrash of the Talmud.The scientific novelty of the study consists in the fact that for the first time a semantic-semantic analysis was carried out and the interrelationships of cultural codes in the pictorial semiosis of the Jews of the Crimea were determined, with an emphasis on the Rimon code.
Awareness of Zoonotic Diseases among the Bachelor of Science New Entrants at the Open University of Sri Lanka in 2020
Authors: Kulatunga Vidyani , Fernando Shehani , Jayawardena Uthpala , Jayasinghe Chanika 
Published: April 2023

Global attention towards zoonotic diseases has been oriented with the emergence of the COVID-19 pandemic in 2020 as they are infectious diseases that can be transmitted from animals to humans, and they pose a significant threat to public health. This study draws on the awareness of a group of new BSc degree registrants (N=267) at The Open University of Sri Lanka in 2020 about common zoonotic diseases. A cross-sectional study was employed for the participants in a virtual orientation session in December 2020 using a structured online questionnaire. Pearson Chi-square test (χ2) was used evaualte statistical significance at p<0.05. The survey reveals that from the total respondents, 89.9% were aware of zoonotic diseases in humans by animals, 77.9% are aware that zoonotic diseases can be transmitted to humans by direct contact with infected animals and 75.3% knew that zoonotic diseases can be transmitted by eating raw meat of infected animals. Further, 82.4% and 86.1% of respondents agreed that zoonotic diseases could be treated and prevented while 85.4% agreed that zoonotic diseases could be controlled. The majority of the respondents were aware of Rabies, Covid 19, Malaria, Dengue fever and SARS as zoonotic diseases and a higher proportion of female respondents identified Hepatitis E as a zoonotic disease. Bovine tuberculosis was identified by students who studied biological sciences compared to other streams. Respondents below 24 years of age identified Anthrax and Leptospirosis, SARS and Trichinellosis as zoonotic diseases than other age categories. Students in suburban areas had a higher tendency to identify Ebola virus disease, Giardiasis, and Hepatitis E as zoonotic diseases. Urban and suburban students had a higher tendency to wash their hands thoroughly after petting the animals. Pet owners only identified Giardiasis as a zoonotic disease and agreed that avoiding direct contact with animals, avoidance of rearing pets indoors and discarding pet faeces in a proper place as good practices to avoid the transmission of zoonoses. Most of the respondents agreed that zoonotic diseases could be prevented by avoiding eating raw meat, avoiding eating unwashed fresh fruits and vegetables, avoiding direct contact with animals, avoiding rearing pets indoors, regular vaccination of pets, proper discharge of animal faeces, washing the hands thoroughly after petting the animals. Overall, this study revealed that the level of awareness about zoonotic diseases among the new BSc registrants was satisfactory. It is inferred that the students could be more educated about the preventive and control measures for zoonotic diseases. It is expected that students will develop essential life skills that are required for the prevention and control of diseases.
Comparative Analysis of the Elementary and Amino Acid Composition of Nepeta olgae Regel L. Plants Growing in Uzbekistan
Authors: Mamadjonova M. Yu. , Dekhkanov R. S. , Abdullaev Sh. V. 
Published: April 2023

This article for the first time presents the results of the study of qualitative and quantitative elemental and amino acid composition of the aboveground part of the plant Nepeta olgae Regel (L.) taken in the territory of Chust and Kosonsai districts (from the slopes of Gova and Kosonsai mountains) of Namangan region during the period before and during flowering (May-June, 2021-2022).
The use of instrumental analysis of high-throughput energy dispersive X-ray fluorescence spectrometry, allowed to establish 20 mineral elements in the plant Nepeta olgae Regel (L.), among which to vital 9 elements and 3 to conditionally necessary.
The amino acid composition of the plant Nepeta olgae Regel (L.) was studied by high performance liquid chromatography (HPLC) and 17 compounds were identified. Of these, 8 were substitutable and 9 essential amino acids.
Clinical Insight on Warfarin Induced Diffuse Alveolar Haemorrhage: A Case Report
Authors: Harine G. , Jeevitha S. , Suresh S. 
Published: April 2023

Background: Diffuse alveolar haemorrhage (DAH) is a serious condition which requires a medical emergency. A contributing factor to DAH is anticoagulant treatment. Warfarin has been used as prophylaxis and treatment of venous thrombosis, thromboembolic complications from atrial fibrillation or cardiac valve replacement. Warfarin-induced diffuse alveolar haemorrhage is a serious medical condition. Initially, the diagnosis of DAH and for other pulmonary conditions clinical presentation and chest X-ray were enough to suggest the diagnosis.
Case Report: In this report a 72-year-old female patient with a history of Coronary Artery Disease (CAD), Hypertension, and surgical procedure of Aortic Valve Replacement (AVR) and Percutaneous Transluminal Coronary Angioplasty (PTCA). She was on warfarin therapy for 5 years and was admitted to the hospital for severe cough, haemoptysis and dyspnoea. DAH was suspected clinically and confirmed by Computed Tomography (CT) chest and bronchoscopy. The patient required treatment with non-invasive ventilation and fresh frozen plasma and other supportive care. Early diagnosis and treatment are highlighted in our case and an anticoagulation reversal is required. Therefore, it is important to carefully monitor patients receiving warfarin therapy for the main symptoms of such an incident and to start treatment as soon as possible in order to reduce mortality.
Study of Soil and Crop Parameters of Coconut Orchard for Design of Tractor Operated Coconut Basin Lister Cum Fertilizer Applicator
Authors: Srinivas Jinukala , Jayan P. R. , Chakravarthi N. L. Kalyan 
Published: April 2023

Aims: To study the soil and crop parameters of coconut orchard for the design of tractor operated coconut basin lister cum fertilizer applicator.
Place and Duration of Study: The study was conducted in Instructional Farm, KCAET in the Year 2021.
Methodology: Soil parameters such as moisture content, bulk density, cone index and shear strength; crop parameters such as trunk diameter and root zone depth of coconut palm were studied using standard procedures to design tractor operated coconut basin lister cum fertilizer applicator.
Results: The soil moisture content varied from 13.2 to 15.6% with mean of 14.66%. The soil bulk density ranged from 1615 to 1865 kg m-3 with mean of 1696.6 kg m-3. The soil cone index varied from 0.428 to 1.506 N mm-2 with mean of 1.041 N mm-2. The soil shear strength varied from 1.47×10-3 to 3.13×10-3 N mm-2 with mean of 2.31×10-3 N mm-2. The trunk diameter of coconut palm varied from 32.3 to 38.1 cm with mean of 34.74 cm. The root zone depth of coconut palm varied from 13.4 to 15.2 cm with mean of 14.3 cm.
Conclusion: Soil moisture content, bulk density, cone index and shear strength helped in the design of power requirement, rotor shaft, cutting blades, main shaft etc. of the machine. The trunk diameter of the coconut palm aided in deciding the working width of the machine while the root zone depth assisted in finalizing the operational depth of the machine.
Patterns of Computed Tomography Urography Findings in a Tertiary Hospital in Rivers State: 2 Years Retrospective Study
Authors: Akagbue Vivian Ndidi , Wekhe Chidinma , Amadi Mary-Jane Orevaoghene , Robinson Ebbi Donald 
Published: April 2023

Background: Computed tomography urography (CTU), is a radiological examination and has largely replaced traditional intravenous urography (IVU) as the gold standard in the imaging of the genitourinary tract, hence it is now used as a primary imaging technique to evaluate patients with diseases involving the urinary tract.
Objective: The aim of this study is to ascertain and document the indications as well as possible findings on CTU carried out on various patients sent to the Radiology department of a tertiary hospital in our environment.
Methods: A retrospective study and descriptive design was employed in this study. A total of 140 patient’s data was used. A P-value below 0.05 was considered statistically significant.
Results: One-hundred and forty patients were studied over a 24months period. The commonest age range is 41 to 50 years and also with most abnormalities. It also showed that more males presented for CTU than females. The most frequent indication for CTU is flank pain (31.4%, n=44). The most common finding in this study is hydronephrosis (39.3%, n=55) and it showed significant association with age (P-value=0.036). Stone is the next common finding with the inferior pole (n=23, 48.9%) as the commonest site for stones. Few congenital anomalies were noted with kinked ureters (n=9, 50.0%) been the most common. Right sided renal cyst is more frequent that left (n=21, 44.7% vs n=20, 42.6%) and inferior pole is the most common location.
Conclusion: CTU is the imaging modality of choice in evaluating the genitourinary system with the advantage of giving additional information about other abdominal structures. Flank pain is the most prevalent indication in this study. Hydronephrosis is the commonest finding with significant association with age.