bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influence of chest/head circumference ratio at birth on obstetric and neonatal outcomes: The Japan environment and children's study
Authors: J.‐P. Naw Awn , Mitsuda Naomi , Eitoku Masamitsu , Yamasaki Keiko , Maeda Nagamasa , Fujieda Mikiya , Suganuma Narufumi ,   The Japan Environment and Children's Study (JECS) Group
Published: February 2023

AbstractObjectivesSome newborns that are not small‐for‐gestational‐age (non‐SGA, birthweight ≥10th percentile for a given gestational age) may have pathologic growth restrictions. This study examined the association of adverse obstetric and neonatal outcomes with chest/head circumference ratio at birth in non‐SGA and SGA newborns.MethodsThis study was a cross‐sectional evaluation of data from a nationwide prospective birth cohort study, the Japan Environment and Children's Study. We analyzed 93 690 non‐anomalous singletons born at 34–41 gestational weeks. We defined low, normal, and high chest/head circumference ratio as <10th percentile, 10th–90th percentile, and >90th percentile, respectively, according to the internally constructed chest/head circumference percentile chart. Modified Poisson regression was used to estimate adjusted prevalence ratios (aPR) for the outcomes studied.ResultsCompared with non‐SGA newborns with a normal ratio, those with a low ratio had an increased occurrence of low birthweight (1.75, 1.58–1.94 [aPR, 95% confidence interval]), cesarean delivery (1.34, 1.29–1.38), Apgar score <7 at 5 min (1.57, 1.14–2.17), respiratory complications (1.20, 1.04–1.39), and prolonged hospitalization (1.36, 1.30–1.42). In contrast, the high‐ratio group had a lower rate of low birthweight (0.71, 0.59–0.86), cesarean delivery (0.82, 0.77–0.87), and prolonged hospitalization (0.83, 0.78–0.89). In SGA newborns, a low ratio was associated with increased aPRs for low birthweight, cesarean delivery, hypoglycemia, and prolonged hospitalization, whereas a high ratio showed no such association.ConclusionsFindings indicate that the chest/head circumference ratio at birth influence obstetric and neonatal outcomes regardless of the birthweight status.
Technoeconomic assessment of distillation heat transfer intensification using aeroelastically fluttering reeds
Authors: Blaine Miriam , Realff Matthew J. 
Published: February 2023

AbstractDry cooling, where forced air is the heat transfer medium, is a preferable cooling method in arid locations lacking readily available process water. However, such locations often experience high ambient temperatures that limit the effectiveness of air cooling. The objective of this study is to quantify the economic and energetic benefits of heat transfer intensification via the implementation of aeroelastically fluttering reeds to the air‐cooled condenser of a methanol distillation column. Condenser size and performance, regarding recovered methanol and required fan power, is evaluated across condenser operating temperatures (Tcond) from 60 to 62°C and heat transfer coefficients (U) Ubase–2Ubase for a range of inlet air temperatures based on ambient temperature data from Yuma, Arizona. Under typical design sizing, condenser capital cost was reduced by 6%–35% (1.3Ubase–2Ubase) and nominal methanol recovery was increased from 0.26% to 0.38% (Tcond = 62–60°C). At optimized condenser size, all enhanced U and Tcond pairs increase methanol recovery and reduce fan power costs compared to the optimal Ubase reference. Overall, using enhanced heat transfer to maintain condenser temperature under a wider range of inlet conditions, rather than to reduce operation temperature, produces more favorable performance. Methanol price is not a determining factor in which pairs are profitable. Analysis was repeated for a global warming scenario, revealing more valuable improvements under elevated temperatures. Energy savings from condenser improvement to a methanol production system are not significant with respect to an optimized conventional system. Unit economic and energetic incentives suggest implementation of fluttering reeds may be justified in other applications.
The impact of enhancing publicity and commemoration of body donors at Zhengzhou University, China
Authors: Zhang Shiqiang , Wang Jiannan , Zhang Jingjing , Xu Gaolei , Zhang Zhenhua , Wang Yongkui , Chang Cheng , Chen Xuemei , Li Ming , Cao Jing , Zang Weidong 
Published: February 2023

AbstractAs a fundamental subject of medical education, human anatomy plays a critical role in the development of medical science. However, because of multiple factors including cultural conservativism and limited social understanding, China is facing a particularly severe shortage of bodies donated for anatomy education. Zhengzhou University (ZZU) has continued to uphold whole‐body dissection as the preferred method for medical students to learn anatomy. For this study, records of registered individuals (who have signed a body donation agreement) and donors (whose bodies have been received) from 2001 to 2020 were collected and analyzed. The aim of this study was to explore the factors influencing the body donation program (BDP) at ZZU, and then reinforce the social understanding for the BDP. The results showed a significant increase in the numbers of both registered individuals and donors since 2015, which is the year the publicity and commemoration in honor of donors were increased. There were no significant differences between the biological male and female sexes in the registered individuals, but the number of male donors (12.85 ± 10.86, per year) was significantly higher than that of female donors (4.75 ± 4.53, per year). The current donor profile at ZZU is male in his 60/70s, while the profile of registered individuals is male or female in their 60s. Strengthening the publicity and commemoration in honor of donors may contribute to the implementation of BDPs.
Catalytic Site‐, Diastereo‐, and Enantioselective Cascade Iodocyclization of 2‐Geranylarenols
Authors: Tsuji Yasutaka , Kon Kazumasa , Horibe Takahiro , Ishihara Kazuaki 
Published: February 2023

AbstractA chiral amidophosphate‐N‐iodosuccinimide cooperative catalysis has been developed for the site‐, diastereo‐, and enantioselective iodocyclization of 2‐geranylarenols with molecular iodine to give the corresponding iodo‐containing polycyclic compounds with good levels of selectivity. This is the first example of a catalytic enantioselective iodocarbocyclization. A reactive chiral iodonium species is generated from molecular iodine via the dual halogen‐bonding interactions with a chiral Lewis base and Lewis acid. The sterically demanding 3,3′‐substituents of the chiral BINOL‐derived amidophosphate are critical to induce the site‐selective iodination at the less‐hindered terminal alkenyl moiety of 2‐geranylarenols.
Fault‐tolerant control strategy for multicylinder hydraulic press machine based on dynamic control allocation and adjustable multiobjective optimization
Authors: Jia Chao , Sun Yulin , Du Lifeng , Wang Hongkun 
Published: February 2023

AbstractA hierarchical controller is proposed for achieving high‐accuracy control and the dynamic balance with the presence of multiple faults of actuator, the external disturbance, and the model uncertainties in multicylinder hydraulic press machine (MCHPM). The method divides the controller design into three steps: Virtual fault‐tolerant control law, control allocation algorithm, and actuator control law, which are progressive. First, to precisely compensate the lumped disturbances including the multiple faults of actuator, the external disturbance, and the model uncertainties, a disturbance observer (DO) is developed. By combining the observer with the sliding mode control (SMC), a virtual fault‐tolerant control law is designed. Second, a highly integrated control allocation algorithm for the virtual fault‐tolerant control law is proposed to get the desired driving force, taking into account dynamic control allocation (DCA), multiobjective optimization (MOO) and Analytic Hierarchy Process (AHP) simultaneously. Third, taking the driving force obtained from above control allocation algorithm as the desired target, the control law of each cylinder is calculated. The global stability for the whole system is proved by the Lyapunov theory. Lastly, results of simulation and experiment show that the proposed controller can effectively handle different faults and have more superior control performance.
Characterization and drivers of haloacetic acids in New York State
Authors: Sayess Rassil , Steinschneider Scott 
Published: February 2023

AbstractThe formation of disinfection byproducts (DBPs) in finished drinking water is an ongoing challenge for public health agencies and water utilities. The Fourth Unregulated Contaminant Monitoring Rule data were used to assess the prevalence and drivers of haloacetic acids (HAAs)—a class of DBPs—in New York State's (NYS) public water systems, with a focus on total measured (HAA9), regulated (HAA5), brominated (HAA6Br), and unregulated (HAA4) HAAs. The concentrations of all HAA groups in NYS are found to be similar to those nationally, with HAA4 composing approximately 20% of HAA9. Concentrations of all HAA groups are lowest in groundwater and highest in surface waters across NYS systems. Higher total organic carbon (TOC) concentrations lead to elevated HAA9 and HAA5, while higher bromide concentrations favor more HAA4 and HAA6Br. HAA4 concentrations are well predicted with pre‐oxidation/disinfection types, HAA5, TOC, and bromide concentrations, with an adjusted R2 of 70%.
Supportive care in a patient with Alstrom syndrome with hyperphenylalaninemia and sleep problems
Authors: Jalilolghadr Shabnam , Saffari Fatemeh , Alizadeh Mehdi , Taremiha AliReza , Ghodsi Marjan , Ghodsi Mersedeh 
Published: February 2023

AbstractAlstrom syndrome is a rare genetic disorder with an autosomal recessive mutation in the ALMS1 gene. The disease's manifestations include ophthalmic problems, hearing loss, obesity, and cardiovascular disorders. In addition, medical cases include other organ complications. However, the overlapping variety of such symptoms with other diseases may delay the diagnosis. In this article, we describe the case of a 7‐year‐old female patient with Alstrom syndrome, and cardiovascular and hyperphenylalaninemia diseases since birth. Other symptoms included diabetes and ophthalmologic problems with skeletal disability. Blindness and hearing impairment were diagnosed, along with recurrence of respiratory problems at the age of 7 years. The patient's obesity‐induced snoring predisposed her to uncontrolled blood glucose. In fact, respiratory tract problems and sleep disorders had occurred as a degraded cycle and left her with a severe disability for years. The similarity of the symptoms with other diseases had misled the physician in diagnosis. However, a polysomnography test (because of complaints of short sleep duration) recognized the source of the patient's sleep disorders and breathing problems. Eventually, we delivered a portable ventilator to the child for continuous positive airway pressure (CPAP) therapy. The child's breathing and oxygenation conditions improved. Using the ventilator and the CPAP system, we discharged her from the hospital without requiring oxygenation, in a stable condition. The procedure could prevent the patient from hypoxia and retinal problem.
Binder‐Free N‐Functionalized Carbon Electrodes for Oxygen Evolution Reaction
Authors: Song Feihong , Straten Jan W. , Lin Yang‐Ming , Ding Yuxiao , Schlögl Robert , Heumann Saskia , Mechler Anna K. 
Published: February 2023

AbstractThe oxygen evolution reaction (OER) is one of the bottlenecks of electrochemical water splitting. Metal‐free carbons from biomass are highly abundant and can be easily synthesized. Their low price, high conductivity and functionalization makes them promising materials. Herein, we report about free‐standing carbon electrodes as electrocatalysts for the OER. In contrast to powder‐based catalysts, free‐standing electrodes not only avoid additives, but also facilitate post analysis and better reflect industrial conditions. Here, the performance of pure carbon electrodes is compared to those of N‐functionalized ones. Utilizing several analytical techniques, the difference in performance can be rationalized by physical properties. Especially, the analysis of the gaseous products is shown to be of crucial importance. It reveals that N‐doped carbons generate more oxygen and are more robust against carbon corrosion. This illustrates the importance of measuring selectivity especially for carbon electrocatalysts, as higher currents do not necessarily result in higher catalytic activity.
Full‐Color Emissive D‐D‐A Carbazole Luminophores: Red‐to‐NIR Mechano‐fluorochromism, Aggregation‐Induced Near‐Infrared Emission, and Application in Photodynamic Therapy
Authors: Chen Zhao , Qin Huan , Yin Ya , Deng Dian‐dian , Qin Si‐Yong , Li Nan , Wang Kai , Sun Yue 
Published: February 2023

AbstractInvited for the cover of this issue are Zhao Chen at Jiangxi Science and Technology Normal University and Yue Sun at Tiangong University. For this cover picture, yellow ball containing character “D” represents donor, green ball containing character “A” represents acceptor. The image depicts eight donor–donor–acceptor‐type carbazole derivatives that display full‐color emission, and a luminogen that shows red to near‐infrared mechano‐fluorochromism and a photodynamic therapy effect. Read the full text of the article at 10.1002/chem.202203797.
Circular Polymers from Ring‐Opening Polymerization of Five‐Membered (Thio)lactones and Derivatives
Authors: Weng Chaoqun , Tang Xiaoyan 
Published: February 2023

AbstractThe short lifespan of most commercial plastics as disposables and the failure to adequately address the end‐of‐life issues of synthetic polymers have led to outrageous global plastic pollution and resource depletion. To solve the problem, one of the most effective strategies is to develop circular polymers and thus establish a new circular material economy. Polymers from ring‐opening polymerization of five‐membered (thio)lactones contribute greatly to this field due to their excellent material performance and recyclability. The emerging topic emphasizes on the monomer design strategies based on five‐membered (thio)lactones, and compares the thermal and mechanical properties and depolymerizability of the resulting polymers with different structures.
Segment regression model average with multiple threshold variables and multiple structural breaks
Authors: Liu Pan , Li Jialiang 
Published: February 2023

AbstractWe propose a new model averaging approach to investigate segment regression models with multiple threshold variables and multiple structural breaks. We first fit a series of models, each with a single threshold variable and multiple breaks over its domain, using a two‐stage change point detection method. Then these models are combined together to produce a weighted ensemble through a frequentist model averaging approach. Consequently, our segment regression model averaging (SRMA) method may help identify complicated subgroups in a heterogeneous study population. A crucial step is to determine the optimal weights in the model averaging, and we follow the familiar non‐concave penalty estimation approach. We provide theoretical support for SRMA by establishing the consistency of individual fitted models and estimated weights. Numerical studies are carried out to assess the performance in low‐ and high‐dimensional settings, and comparisons are made between our proposed method and a wide range of existing alternative subgroup estimation methods. Two real economic data examples are analyzed to illustrate our methodology.
Hierarchically Structured NH2‐MIL‐125/TiO2/Cellulose Composite Membranes With Enhanced Photocatalytic Performance
Authors: Yang Zhan , Lin Zehao , Huang Jianguo 
Published: February 2023

AbstractA cellulose‐based photocatalytic membrane was fabricated by in situ growth of the NH2‐MIL‐125 nanoparticles onto the surfaces of the ultrathin titania (TiO2) gel layers pre‐coated cellulose nanofibres of natural cellulose substance (commercial laboratory filter paper). The NH2‐MIL‐125 nanoparticles were grown on the surface of the titania gel coated cellulose nanofibres via a one‐step solvothermal method. The resultant composite membranes maintained the initial hierarchical network structures of the bulk cellulose substance, consisting titania gel layer coated cellulose nanofibres with NH2‐MIL‐125 nanoparticles anchored on the surfaces. Owing to the hierarchical porous structure of the cellulose substrates as well as the effective heterostructure formation between the NH2‐MIL‐125 particles and the TiO2 layers, the composites showed enhanced photocatalytic performances. The NH2‐MIL‐125/TiO2/cellulose composite composed of 15.82 wt% NH2‐MIL‐125 content with nanoparticles sizes of 100–200 nm showed an apparent rate constant of 0.032 min−1 in photocatalytic degradation of Rhodamine B (RhB), which was higher than those of the NH2‐MIL‐125/cellulose composite and the TiO2/cellulose composite. It was demonstrated that pre‐coating of the cellulose nanofibres with ultrathin titania gel layers was essential for the growth of the NH2‐MIL‐125 nanoparticles thereon.
Oral Oxycodone‐Induced Respiratory Depression During Normocapnia and Hypercapnia: A Pharmacokinetic‐Pharmacodynamic Modeling Study
Authors: Hellinga Marieke , Algera Marijke Hyke , Olofsen Erik , van der Schrier Rutger , Sarton Elise , van Velzen Monique , Dahan Albert , Niesters Marieke 
Published: February 2023

The widely prescribed opioid oxycodone may cause lethal respiratory depression. We compared the effects of oxycodone on breathing and antinociception in healthy young volunteers. After pharmacokinetic/pharmacodynamic (PK/PD) modeling, we constructed utility functions to combine the wanted and unwanted end points into a single function. We hypothesized that the function would be predominantly negative over the tested oxycodone concentration range. Twenty‐four male and female volunteers received 20 (n = 12) or 40 (n = 12) mg oral oxycodone immediate‐release tablets. Hypercapnic ventilatory responses (visit 1) or responses to 3 nociceptive assays (pain pressure, electrical, and thermal tests; visit 2) were measured at regular intervals for 7 hours. the PK/PD analyses, that included carbon dioxide kinetics, stood at the basis of the utility function: probability of antinociception minus probability of respiratory depression. Oxycodone had rapid onset/offset times (30–40 minutes) with potency values (effect‐site concentration causing 50% of effect) ranging from 0.05 to 0.13 ng/mL for respiratory variables obtained at hypercapnia and antinociceptive responses. Ventilation at an extrapolated end‐tidal carbon dioxide partial pressure of 55 mmHg, was used for creation of 3 utility functions, one for each of the nociceptive tests. Contrary to expectation, the utility functions were close to zero or positive over the clinical oxycodone concentration range. The similar or better likelihood for antinociception relative to respiratory depression may be related to oxycodone's receptor activation profile or to is high likeability that possibly alters the modulation of nociceptive input. Oxycodone differs from other μ‐opioids, such as fentanyl, that have a consistent negative utility.
The relationship between subjective oral frailty and adverse health outcomes or medical and dental expenditures in the latter‐stage older adult: A 6‐year longitudinal study
Authors: Doi Tokiko , Fukui Makoto , Yoshioka Masami , Okamoto Yoshifumi , Shimomura Manabu , Matsumoto Kimi , Matsuyama Miwa , Hinode Daisuke 
Published: February 2023

AbstractObjectivesThe study aimed to investigate the relationship between subjective oral frailty and adverse health outcomes or medical and dental expenditures in the latter‐stage older adult through a 6‐year longitudinal study.MethodsThe participants enrolled in the cross‐sectional study were 3564 Tokushima City residents aged 75, 80, 85, and 90 years old who received oral health examinations and who responded to a questionnaire on oral conditions and health behavior at baseline. The data for the occurrence of disability or mortality, and the monthly medical expenditures, dental expenditures, and total medical expenditure of each participant were obtained from the National Health Insurance Database.ResultsThe total medical expenditure showed significant differences in participants who had difficulties in eating tough foods, difficulties in swallowing tea or soup, and dry mouth when compared to that of healthy participants, in addition to the current medical treatment against the general disease. The 6‐year longitudinal study revealed that participants with subjective oral frailty symptoms, including difficulties in eating tough foods and difficulties in swallowing tea or soup at baseline, had significantly higher medical, dental, and total expenditures among 538 participants without certified nursing care. In addition, those with subjective oral frailty or with less than 19 teeth present were shown to have a higher possibility for the occurrence of disability or mortality by the cox proportional hazard analysis. Furthermore, it was found that medical and total expenditures in older adults with adverse health outcomes were higher than that of healthy participants.ConclusionThese results suggest that subjective oral frailty in the latter‐stage older adult is related to subsequent adverse health outcomes and an increase in medical and dental expenditures.
OMIP‐090: A 20‐parameter flow cytometry panel for rapid analysis of cell diversity and homing capacity in human conventional and regulatory T cells
Authors: Stroukov Wladislaw , Mastronicola Daniela , Albany Caraugh Jane , Catak Zeynep , Lombardi Giovanna , Scottà Cristiano 
Published: February 2023

AbstractThe panel was developed and optimized for monitoring changes in homing capacity and functional diversity of human CD4+ conventional and regulatory T cell subsets. The analysis was based on expression of only surface markers in freshly isolated peripheral blood mononuclear cells (PBMCs) to reduce at minimum any alteration due to permeabilization or freezing/thawing procedures. We included markers to assess the distribution of naïve and memory populations based on the expression of CD45RA, CCR7, CD25, CD28 and CD95 in both conventional and regulatory T cells. The identification of major functional subsets was performed using CCR4, CCR6, CCR10, CXCR3 and CXCR5. Homing capacity of these subsets to skin, airway tract, gut and inflammatory lesions could finally be assessed with the markers CLA, CCR3, CCR5 and integrin β7. The panel was tested on freshly isolated PBMCs from healthy donors and patients with allergic rhinitis or autoimmune disorders.