bluuebunny/crossref_metadata_2025_split huggingface dataset:
Polyphase rock slope failure controlled by pre-existing geological structures and rock bridges
Authors: Gerstner Reinhard , Fey Christine , Kuschel Erik , Valentin Gerald , Voit Klaus , Zangerl Christian 
Published: August 2023

AbstractEven after decades of intensive research, assessing rock slope stability remains a challenge. One reason for this is the spatial variability of rock bridges (RBs) related to non-persistent, pre-existing geological structures, especially as the detection of RBs is generally limited to the post-failure period. Thus, the identification and classification of RBs and their inclusion in numerical studies are demanding, yet essential, since even small quantities of RBs can be decisive for rock slope stability. In our study, we demonstrate how brittle RB failure and pre-existing geological structures control the mechanisms of a polyphase rock slope failure. Therefore, we present a case study in the Austrian Alps, where three rock falls with a failure volume of 30,000 m3 occurred in 2019. Based on detailed process reconstructions, high-resolution terrain models, and comprehensive geological and rock mechanical investigations, we derived high-quality input for our distinct element model (DEM). By applying asymmetric Voronoi tessellation in the DEM, we modelled the coalescence of pre-existing geological structures by brittle RB failure. As a result, we identified toppling as the predominant failure mechanism at the study site. Distinctive geological structures decisively affected the failure mechanism. However, the toppling failure was only reproducible by incorporating RBs in the DEM in their pre-failure position. Finally, we found that joint persistence, and consequently the presence of potential RBs, controls which initial rock fall failure mechanism was developed. In conclusion, we state that the initial toppling failure of the Hüttschlag rock falls is controlled by non-persistent geological structures in interplay with RBs.
Recurrent or junctional lumbar foraminal herniated disc in patients operated with trans pars microscopic approach
Authors: Monticelli Matteo , Gelmi Clarissa Ann Elisabeth , Scerrati Alba , Cavallo Michele Alessandro , De Bonis Pasquale 
Published: August 2023

AbstractThis is a retrospective monocentric study. The aim of this study is to analyze the incidence of recurrent or junctional lumbar foraminal herniated disc, in patients treated with trans pars microsurgical approach. Foraminal lumbar disc herniation represents a challenging pathology for the spinal surgeon. The appropriate surgical approach still represents a matter of debate. Several open and minimally-invasive techniques have been developed, in order to allow a proper tissue exposure and preserving the vertebral stability. The trans pars approach has already been described as a possible alternative, allowing excellent exposure of the herniated fragment with minimum bone removal. While few studies have analyzed the very low rate of post-operative instability, no articles deal with the incidence of post-operative herniated disc recurrence or junctional disc herniation in patients treated with this technique. We enrolled 160 patients operated at our institution. A univariate and multivariate analysis of possible factors influencing outcome (age, sex, level and BMI) was performed. Outcome variables were recurrent or junctional herniated disc. At the end, 135 patients were analyzed. Of the 135 patients, six presented recurrent herniated disc (4.4%) and other three developed a junctional herniation (2.2%). The occurrence of junctional herniated disc or recurrent herniated disc was not influenced by the analyzed variables, both at univariate and at multivariate analyses. The trans pars approach presents a low rate of recurrence and junctional herniation. Age, sex, level, and BMI do not influence the recurrence rate, both at same level and at junctional level.
Wage Structures, Fairness Perceptions, and Job Satisfaction: Evidence from Linked Employer-Employee Data
Authors: Mohrenweiser Jens , Pfeifer Christian 
Published: August 2023

AbstractThe paper investigates the impact of firms’ wage structures and workers’ wage fairness perceptions on workers’ well-being. For this purpose, worker and establishment surveys are linked with administrative social security data. Four variables are generated, using approximately half a million worker-year observations, that describe firms’ wage structures and workers’ positions within the wage structures: own absolute wages, internal reference wages within firms, external reference wages, and the wage dispersion in firms. The interrelations between these wage structure variables, workers’ perceived wage fairness, and job satisfaction are then analyzed using regressions. Interpersonal wage comparisons between co-workers in the same firm and across firms as well as wage fairness perceptions are found to be significant determinants of workers’ well-being. The overall findings suggest that equity and social status considerations as well as altruistic preferences towards co-workers and inequality aversion are more important than signal considerations in this context.
Sterol and lipid metabolism in bees
Authors: Furse Samuel , Koch Hauke , Wright Geraldine A. , Stevenson Philip C. 
Published: August 2023

Abstract
Background
Bees provide essential pollination services for many food crops and are critical in supporting wild plant diversity. However, the dietary landscape of pollen food sources for social and solitary bees has changed because of agricultural intensification and habitat loss. For this reason, understanding the basic nutrient metabolism and meeting the nutritional needs of bees is becoming an urgent requirement for agriculture and conservation. We know that pollen is the principal source of dietary fat and sterols for pollinators, but a precise understanding of what the essential nutrients are and how much is needed is not yet clear. Sterols are key for producing the hormones that control development and may be present in cell membranes, where fatty-acid-containing species are important structural and signalling molecules (phospholipids) or to supply, store and distribute energy (glycerides).

Aim of the review
In this critical review, we examine the current general understanding of sterol and lipid metabolism of social and solitary bees from a variety of literature sources and discuss implications for bee health.

Key scientific concepts of review
We found that while eusocial bees are resilient to some dietary variation in sterol supply the scope for this is limited. The evidence of both de novo lipogenesis and a dietary need for particular fatty acids (FAs) shows that FA metabolism in insects is analogous to mammals but with distinct features. Bees rely on their dietary intake for essential sterols and lipids in a way that is dependent upon pollen availability.
Demonstration of T2SLs InAs/InAsSb Based Interband Cascade Detector Supported by Immersion Lens for LWIR
Authors: Gawron Waldemar , Kubiszyn Łukasz , Michalczewski Krystian , Jureńczyk Jarosław , Piotrowski Józef , Martyniuk Piotr 
Published: August 2023

AbstractThis paper presents the performance of an interband cascade long-wavelength infrared detector designed for high operating temperatures supported by immersion lenses. The device is based on the “Ga-free” InAs/InAsSb type-II superlattice with highly doped p+/n+ superlattice tunneling junctions connecting adjacent stages. Detectivity of the multi-junction heterostructure detector exceeding 1010 cm Hz1/2/W was estimated at wavelength λ ~ 9 µm and T = 210 K and ~ 3 × 108 cm Hz1/2/W for T = 300 K, achieving a tenfold improvement in detectivity in comparison to a device without an immersion lens and 30-fold improvement in detectivity in comparison to the single-stage device.
The association of cancer-related fatigue on the social, vocational and healthcare-related dimensions of cancer survivorship
Authors: Jones Jennifer M. , Howell Doris , Longo Christopher , Olson Karin , Bedard Philippe , Amir Eitan , Zheng Shiyu , Chow Brittany , Avery Lisa 
Published: August 2023

Abstract

Background
Cancer-related fatigue (CRF) is well documented in cancer survivors, but little is known about the personal and societal impact of CRF. This study aimed to examine the impact of CRF in relation to social and vocational functioning and health care utilization in a large sample of post-treatment cancer survivors.

Methods
We conducted a cross-sectional descriptive study of early stage breast and colorectal cancer survivors (n = 454) who were within 5 years from treatment completion. Social difficulties (SDI-21), work status, absenteeism and presenteeism (WHO-HPQ) and healthcare utilization (HSUQ) were compared in those with (CFR +) and without (CRF −) clinically significant fatigue (FACT-F ≤ 34).

Results
A total of 32% met the cut-off criteria for CRF (≤ 34). Participants with CRF + had significantly higher scores on the SDI-21 across all domains and 55% of CRF + vs. 11% in CRF − was above the SDI cut-off (> 10) for significant social difficulties. Participants with CRF + were 2.74 times more likely to be unemployed or on leave (95% CI 1.62, 4.61, p < 0.001). In the subgroup of participants who were currently working (n = 249), those with CRF + reported working on average 27.4 fewer hours in the previous 4 weeks compared to CRF − (p = 0.05), and absolute presenteeism was on average 13% lower in the CRF + group (95% CI 8.0, 18.2, p < 0.001). Finally, individuals with CRF + reported significantly more physician (p < 0.001), other health care professional (p = 0.03) and psychosocial visits (p = 0.002) in the past month.

Conclusions and implications for cancer survivors
CRF is associated with substantial disruption in social and work role functioning in the early transitional phase of cancer survivorship. Better management of persistent CRF and funding for the implementation of existing guidelines and recommended evidence-based interventions are urgently needed.
Caveolin-1 promotes glioma progression and maintains its mitochondrial inhibition resistance
Authors: Liu Yu’e , Chen Yi , Wang Fei , Lin Jianghua , Tan Xiao , Chen Chao , Wu Lei-lei , Zhang Xiaoling , Wang Yi , Shi Yufeng , Yan Xiaoli , Zhao Kaijun 
Published: August 2023

Abstract
Background
Glioma is a lethal brain cancer and lacking effective therapies. Challenges include no effective therapeutic target, intra- and intertumoral heterogeneity, inadequate effective drugs, and an immunosuppressive microenvironment, etc. Deciphering the pathogenesis of gliomas and finding out the working mechanisms are urgent and necessary for glioma treatment. Identification of prognostic biomarkers and targeting the biomarker genes will be a promising therapy.

Methods
From our RNA-sequencing data of the oxidative phosphorylation (OXPHOS)-inhibition sensitive and OXPHOS-resistant cell lines, we found that the scaffolding protein caveolin 1 (CAV1) is highly expressed in the resistant group but not in the sensitive group. By comprehensive analysis of our RNA sequencing data, Whole Genome Bisulfite Sequencing (WGBS) data and public databases, we found that CAV1 is highly expressed in gliomas and its expression is positively related with pathological processes, higher CAV1 predicts shorter overall survival.

Results
Further analysis indicated that (1) the differentiated genes in CAV1-high groups are enriched in immune infiltration and immune response; (2) CAV1 is positively correlated with tumor metastasis markers; (3) the methylation level of CAV1 promoters in glioma group is lower in higher stage than that in lower stage; (4) CAV1 is positively correlated with glioma stemness; (5) higher expression of CAV1 renders the glioma cells’ resistant to oxidative phosphorylation inhibitors.

Conclusion
Therefore, we identified a key gene CAV1 and deciphered its function in glioma progression and prognosis, proposing that CAV1 may be a therapeutic target for gliomas.

Graphical Abstract
Narciclasine, a novel topoisomerase I inhibitor, exhibited potent anti-cancer activity against cancer cells
Authors: Wang Meichen , Liang Leilei , Wang Rong , Jia Shutao , Xu Chang , Wang Yuting , Luo Min , Lin Qiqi , Yang Min , Zhou Hongyu , Liu Dandan , Qing Chen 
Published: August 2023

AbstractDNA topoisomerases are essential nuclear enzymes in correcting topological DNA errors and maintaining DNA integrity. Topoisomerase inhibitors are a significant class of cancer chemotherapeutics with a definite curative effect. Natural products are a rich source of lead compounds for drug discovery, including anti-tumor drugs. In this study, we found that narciclasine (NCS), an amaryllidaceae alkaloid, is a novel inhibitor of topoisomerase I (topo I). Our data demonstrated that NCS inhibited topo I activity and reversed its unwinding effect on p-HOT DNA substrate. However, it had no obvious effect on topo II activity. The molecular mechanism of NCS inhibited topo I showed that NCS did not stabilize topo-DNA covalent complexes in cells, indicating that NCS is not a topo I poison. A blind docking result showed that NCS could bind to topo I, suggesting that NCS might be a topo I suppressor. Additionally, NCS exhibited a potent anti-proliferation effect in various cancer cells. NCS arrested the cell cycle at G2/M phase and induced cell apoptosis. Our study reveals the antitumor mechanisms of NCS and provides a good foundation for the development of anti-cancer drugs based on topo I inhibition.
Graphical abstract
Mindfulness-Based Stress Reduction in the Treatment of Adults with Autism Spectrum Disorder: a Systematic Review of Interventional Studies
Authors: Forbes Zac N. M. , Miller Kim 
Published: August 2023

AbstractAdults with autism spectrum disorder (ASD) have a lower quality of life (QoL) than neurotypical adults and a higher risk of psychiatric comorbidities. We reviewed the effectiveness of mindfulness-based stress reduction (MBSR) in the treatment of adults with ASD. Data were collected from 6 eligible interventional studies (4 adequate quality, 2 weak quality; 245 total participants). The study quality and certainty of findings were assessed using Evaluative Method for Determining Evidence-Based Practices in Autism and GRADE framework. MBSR was effective in all outcomes: ASD symptoms (n = 4, low certainty), QoL (n = 5, low certainty), symptoms of anxiety and depression (n = 4, low and moderate certainty, respectively). MBSR shows promise for improving QoL, reducing ASD symptoms and alleviating psychiatric comorbidities in adults with ASD.
Mexicans vs Central Americans: Violented Migrants Crossing Mexico
Authors: Fernández-Ortega Miguel Á. , Cerritos-Flores René , Rodríguez-Mendoza Omar , Dávila-Mendoza Rocío , Salas-Sánchez Brandon , Muñiz-Salinas Daniel A. , Martinez-Orea Yuriana ,   Investigation team, Téllez Yossadara Luna , Silva Andrea Macías , Nuñez Flor Mariana Sanchez 
Published: August 2023

Abstract
Introduction
The World Health Organization considers that migrants who pass through the Mexico–US walkway suffer high levels of violence, compared to other regions of the world, mainly women. This study aims to identify the factors associated with the types of violence suffered by migrants in transit through Mexico to the USA.

Design
A cross-sectional, exploratory, retrospective, and observational study was conducted. A questionnaire of 46 variables was applied, divided into four sections: sociodemographic background, leaving the home, transit, and stay at the border. Questions about different types of direct violence were included. The survey was applied to 612 Mexican and Central American migrants who were in the Chaparral customs office and in five shelters in Tijuana City, on the U.S.–Mexico border. The results were analyzed using descriptive techniques and multivariate analysis of main and inferential components, using the statistical program R.

Results
The higher vulnerability of Central American migrants compared to Mexicans was documented, specially of women that proportionally were the most negatively affected victims including all types of violence, making it evident that one of each four was violented sexually and among them, only 50% asked for medical assistance. The multivariate analysis determined that the duration of the trip, and the type of transport can generate greater violence.

Conclusions
The results highlight the greater vulnerability of Central American migrants in their transit through Mexico, mainly women and, likewise, the lack of effective public policies that guarantee the protection of the health, safety, and human rights of migrants.
Zwischen »Bewegung« und Wissenschaft
Authors: Müller Hans-Harald 
Published: August 2023

ZusammenfassungDie Untersuchung dokumentiert, dass die Gründung der Zeitschrift auf die Initiative des Verlegers Hermann Niemeyer zurückging. Sie war das Ergebnis von Verhandlungen, die Niemeyer vor allem mit Paul Kluckhohn und Erich Rothacker führte, von denen der Erstere eine literaturgeschichtliche, der Letztere eine eher wissenschaftsphilosophische Ausrichtung der geistesgeschichtlichen Zeitschrift anstrebte. Der Beitrag schließt mit einem Überblick über die epistemische Situation der Literaturwissenschaft zwischen 1890 und 1920, der zeigt, dass die geistesgeschichtliche Bewegung aus einer weltanschaulichen Reaktion auf die ›Kulturkrise‹ hervorging und in verschiedenartigen Konzeptionen Eingang in die Literaturwissenschaft fand.
Henceforth fishermen and hunters are to be restrained: towards a political ecology of animal usage in premodern Japan
Authors: Hudson Mark , Muñoz Fernández Irene M. 
Published: August 2023

AbstractDomestic animal usage remains a key problem in understanding Japan’s premodern economy. Assumptions that religious and other cultural proscriptions limited the use of domesticated animals, and the consumption of meat in particular, from Late Antiquity until Westernisation in the nineteenth century remain widespread. However, the zooarchaeological record from historic Japan is patchy and the scholarly literature often uncritically reproduces state-centred ideas about agriculture and the economy. In this essay we critically review the ways in which historical and zooarchaeological studies of animal usage in premodern Japan have been impacted by broader cultural discourses. We examine animal usage from the Bronze Age to the eve of modernisation, broadly 1000 BC to AD 1850, in terms of a tension or dialectic between promotion and restriction by the state and other authorities. While the utilisation of animals for warfare and official transport was more closely controlled, other uses reflected a complex and often international political ecology that requires further analysis by zooarchaeologists.
A Scoping Review of the Efficacy and Safety of Methotrexate Compared to Mycophenolate Mofetil in the Treatment of Juvenile Localized Scleroderma in Children and Young Adults
Authors: Singhal Shabnam , Heaf Eleanor , Jordan Joanne L. , Corp Nadia , Pain Clare E. 
Published: August 2023

AbstractJuvenile localised scleroderma (JLS) is a condition that results in inflammation and fibrosis of the skin in children and young people. Systemic treatment with immunomodulation is most commonly with Methotrexate (MTX) or Mycophenolate Mofetil (MMF). Other treatments include DMARDs, biologic therapies, topical treatments and phototherapy. This scoping review considers the available information on the relative safety and efficacy of MTX and MMF. A scoping review was conducted in accordance with PRISMA-ScR guidelines. A search was conducted in three bibliographic databases (Cochrane Library, Medline (OVID) and Embase (OVID)) to identify relevant studies for inclusion . A single reviewer identified published articles eligible for the review based on the inclusion and exclusion criteria. The relevant key findings were summarised in a word document by the first reviewer and then checked by a second reviewer. From 1233 unique references, 109 were identified as meeting the inclusion criteria. MTX is the most commonly used first-line systemic treatment for JLS with the greatest evidence for its use in JLS. The evidence for the efficacy of MMF is restricted to a small number of retrospective studies. Both MTX and MMF are described to be relatively safe medications with a low rate of adverse events. Information regarding the tolerability of these medications is limited. The rarity of JLS and the paucity of validated measures of disease activity makes comparison between these two treatments challenging and should be reflected in the design of future studies.
Net-zero 1.5 °C sectorial pathways for G20 countries: energy and emissions data to inform science-based decarbonization targets
Authors: Teske Sven , Rispler Jonathan , Niklas Sarah , Feenstra Maartje , Mohseni Soheil , Talwar Simran , Miyake Saori 
Published: August 2023

AbstractThis paper documents data for global, regional (EU-27), and country-specific (G20 member countries) energy and emission pathways required to achieve a defined carbon budget of between 400 GtCO2 and 500 GtCO2, developed to limit the mean global temperature rise to 1.5 °C, over 50% likelihood. The data were calculated with the 1.5 °C sectorial pathways of the One Earth Climate Model—an integrated energy assessment model devised at the University of Technology Sydney. The data consist of the following six zip-folder datasets (refer to Sect. 2 for an explanation of the data): (1) Appendix folder: Each file contains one worksheet, which summarizes the overall 1.5 °C scenario. (2) Sector folder (XLSX): Each file contains one worksheet, which summarizes the industry sectors analysed. (3) Sector folder (CSV): The data contained are the same as those described in point 2. (4) Sector emissions folder: Each file contains one worksheet, which summarizes the total annual emissions for each industry sector. (5) Scope emissions folder (XLSX): Each file contains one worksheet, which summarizes the total annual emissions for each industry sector—with the additional specificity of emission scope. (6) Scope emissions folder (CSV): The data contained are the same as those described in point 5.