bluuebunny/crossref_metadata_2025_split huggingface dataset:
IF1 is a cold-regulated switch of ATP synthase to support thermogenesis in brown fat
Authors: Brunetta Henver S. , Jung Anna S. , Valdivieso-Rivera Fernando , Zani Stepheny C. C. , Guerra Joel , Furino Vanessa , Francisco Annelise , Berçot Marcelo , Moraes-Vieira Pedro M. M. , Keipert Susanne , Jastroch Martin , Martinez Laurent O. , Sponton Carlos H. , Castilho Roger F. , Mori Marcelo A. , Bartelt Alexander 
Published: July 2023

AbstractWhile mechanisms controlling mitochondrial uncoupling protein-1 (UCP1) expression and function in thermogenic adipocytes play a pivotal role in non-shivering thermogenesis (NST), it remains unclear whether F1Fo-ATP synthase function is regulated during NST. Here, we show that Inhibitory Factor 1 (IF1, encoded byAtp5if1), an inhibitor of ATP synthase hydrolytic activity, is a critical negative regulator of brown adipocyte energy metabolism. In mice, IF1 protein content is markedly diminished in brown adipose tissue (BAT) after 5 days of cold exposure. Additionally, the capacity of ATP synthase to generate mitochondrial membrane potential through ATP hydrolysis (the so-called “reverse mode” of ATP synthase) is higher in mitochondria isolated from cold- adapted mice compared to mice housed at room temperature.In vitro, IF1 overexpression results in an inability of mitochondria to sustain mitochondrial membrane potential upon adrenergic stimulation and this occurs in a UCP1-dependent manner. In brown adipocytes, IF1 silencing is sufficient to increase mitochondrial lipid oxidation and the cellular dependency on glycolysis to produce ATP. Conversely, IF1 overexpression blunts mitochondrial respiration without causing cellular energetic stress, leading to a quiescent-like phenotype in brown adipocytes. In mice, adeno-associated virus- mediated IF1 overexpression in BAT suppresses adrenergic-stimulated thermogenesis and decreases mitochondrial respiration in this tissue. Taken together, our data shows that the downregulation of IF1 upon cold serves to facilitate the reverse mode of ATP synthase to enable energetic adaptation and effectively support NST in BAT.Graphical abstract
Expression of a STING Gain-of-function Mutation in Endothelial Cells Initiates Lymphocytic Infiltration of the Lungs
Authors: Gao Kevin MingJie , Chiang Kristy , Korkmaz Filiz T , Janardhan Harish Palleti , Trivedi Chinmay M. , Quinton Lee J. , Gingras Sebastien , Fitzgerald Katherine A. , Marshak-Rothstein Ann 
Published: July 2023

AbstractPatients afflicted with STING gain-of-function mutations frequently present with debilitating interstitial lung disease (ILD) that is recapitulated in mice expressing the STINGV154Mmutation (VM). Prior radiation chimera studies revealed an unexpected and critical role for non-hematopoietic cells in the initiation of ILD. To identify STING-expressing non-hematopoietic cell types relevant to ILD, we generated a conditional knock-in (CKI) model in which expression of the VM allele was directed to hematopoietic cells, fibroblasts, epithelial cells, or endothelial cells. Only endothelial cell-targeted expression of the mutant allele resulted in the recruitment of immune cells to the lung and the formation of bronchus-associated lymphoid tissue, as seen in the parental VM strain. These findings reveal the importance of endothelial cells as instigators of STING-driven lung disease and suggest that therapeutic targeting of STING inhibitors to endothelial cells could potentially mitigate inflammation in the lungs of SAVI patients or patients afflicted with other ILD-related disorders.SummaryPatients with STING gain-of-function (GOF) mutations develop life-threatening lung autoinflammation. In this study, Gao et al. utilize a mouse model of conditional STING GOF to demonstrate a role for endothelial STING GOF in initiating immune cell recruitment into lung tissues of SAVI mice.
Perceived Timing of Postural Instability Onset With and Without Vision
Authors: McIlroy Robert E , Barnett-Cowan Michael 
Published: July 2023

AbstractBackgroundVision can significantly impact both the perception and behaviour related to postural control. This study examines the influence of vision on the perception of postural instability onset. Previous research employing Temporal Order Judgment (TOJ) tasks to investigate the perceived timing of postural perturbation onset has not incorporated visual cues.Research questionDoes the presence of visual feedback affect the point of subjective simultaneity (PSS) between postural perturbation onset and an auditory reference stimulus and does this additional sensory cue increase TOJ precision?MethodsUsing a lean-and-release paradigm, 10 participants were exposed to postural perturbations in both eyes closed (EC) and eyes open (EO) conditions using a TOJ task where they indicated whether they perceived postural instability onset or sound onset as occurring first for each trial. Separate paired t-tests between EC and EO PSS and just noticeable difference (JND) values were used. One-sample t-tests were also used on PSS values for both conditions, comparing them to 0ms (true simultaneity).ResultsThe EC condition demonstrated a perceived delay of postural instability onset by 25.78 ms, while the EO condition showed a perceived delay of the auditory stimulus by 12.33 ms. However, no significant differences were found between the conditions or in comparison to true simultaneity. Mean JND values for EC (39.88 ms) and EO (46.48 ms) were not significantly different, suggesting visual information does not affect response precision for this task under these conditions.SignificanceThese findings indicate that visual information does not significantly affect the perception of postural instability onset. This suggests that visual information may play a limited role in the early perceptual stages of postural instability.
Theatre arts in UK city of culture evaluation practices: the case for headphone verbatim
Authors: Ingram Charlie 
Published: July 2023

PurposeThis article's purpose is to examine the case for the use of the theatre arts in the evaluation of UK City of Culture (UKCC) programmes, specifically headphone verbatim.Design/methodology/approachThrough an analysis of secondary evidence, supported by some primary research, this article analyses past and present evaluation practices surrounding UKCC programmes and the case for headphone verbatim to be included as a method of gathering and distributing research data. The article also observes the challenges in how data may be disseminated through verbatim theatre performance practices, given the limited examples of its use in this context.FindingsThe author argues that the theatre arts can provide a different way of knowing and understanding the impacts of UKCC projects on the host city. Specifically, that headphone verbatim can bring an experiential perspective that is rarely if ever captured by existing UKCC evaluation methods and policymaking in general.Originality/valueThis article details an innovative method of evaluating social impacts associated with UKCC projects.
RPAS performance model for fast-time simulation research on integration in non-segregated airspace
Authors: Lichoń Daniel , Majka Andrzej Robert , Lis Tomasz 
Published: July 2023

Purpose
The purpose of this paper was to elaborate the performance model of the remotely piloted aircraft systems (RPAS) which was destined for simulations of the construction characteristics, airspeeds and trajectory of flight in the controlled, non-segregated airspace according to the standard instrument departure and arrival procedures (SIDs and STARs).

Design/methodology/approach
This study used systems engineering approach: decomposition of RPAS performance model into components, relations and its connection with components of controlled the airspace system. Fast-time simulations (FTS) method, which included investigation of many scenarios of the system work, minimizing the number of input variables and low computing power demand, is also used.

Findings
Performance envelope of many fixed-wing RPAS was not published. The representative RPAS geometry configuration was feasible to implement. Power unit model and aerodynamic model needed to be accommodated to RPAS category. The range of aircraft minimum drag coefficient differed in the investigated range of take-off mass and wing loading.

Research limitations/implications
Fixed-wing RPAS of small and medium categories cover take-off mass (25–450 kg), wing loading (40–900 N/m2) and power loading (8–40 W/N).

Practical implications
This is a research on integration of the RPAS in the controlled, non-segregated airspace. The results of the work may be used in broadening the knowledge of the RPAS characteristics from the perspective of operators, designers and air traffic services.

Originality/value
The elaborated performance model of the RPAS used the minimum number of three input variables (take-off mass, wing loading and power loading) in identification of the complete RPAS characteristics, i.e. construction features (aerodynamic, propulsion and loads) and flight parameters (airspeeds and flight trajectory).
Cyber-physical systems and digital twins for “cognitive building” in the construction industry
Authors: Ghansah Frank Ato , Lu Weisheng 
Published: July 2023

Purpose
Despite the growing attention on the relevance of improved building management systems with cognition in recent years in the architecture, engineering, construction and operation (AECO) community, no review has been conducted to understand the human-environment interaction features of cyber-physical systems (CPS) and digital twins (DTs) in developing the concept of a cognitive building (CB). Thus, this paper aims to review existing studies on CPS and DTs for CB to propose a comprehensive system architecture that considers human-environment interactions.

Design/methodology/approach
Scientometric analysis and content analysis were adopted for this study.

Findings
The scientometric analysis of 1,042 journal papers showed the major themes of CPS/DTs for CB, and these can be categorized into three key technologies to realize CB in the AECO community: CPS, DTs and cognitive computing (CC). Content analysis of 44 relevant publications in the built environment assisted in understanding and evidently confirming the claim of this study on the integration of CPS and DTs for CB in construction by also involving the CC. It is found and confirmed that CB can be realized with CPS and DTs along with the CC. A CB system architecture (CBSA) is proposed from the three key technologies considering the human-environment interactions in the loop. The study discovered the potential applications of the CBSA across the building lifecycle phases, including the design, construction and operations and maintenance, with the potential promise of endowing resilience, intelligence, greater efficiency and self-adaptiveness. Based on the findings of the review, four research directions are proposed: human-environment interactions, CB for sustainable building performance, CB concept for modular buildings and moving beyond CB.

Originality/value
This study stands out for comprehensively surveying the intellectual core and the landscape of the general body of knowledge on CPS/DTs for CB in the built environment. It makes a distinctive contribution to knowledge as it does not only propose CBSA by integrating CPS and DTs along with CC but also suggests some potential practical applications. These may require expert judgments and real case examples to enhance reproducibility and validation.
Consumers’ digital self-extension and pro-brand social media engagement – the role of culture
Authors: Rabbanee Fazlul K. , Roy Rajat , Roy Sanjit K. , Sobh Rana 
Published: July 2023

Purpose
Digital self-expression, recently one of the most important research themes, is currently under-researched. In this context, this study aims to propose a parsimonious research model of self-extension tendency, its drivers and its outcomes. The model is tested in the context of social media engagement intentions (liking, sharing and commenting) with focal brands and across individualist versus collectivist cultures.

Design/methodology/approach
The model is tested in two individualist cultures (N = 230 and 232) and two collectivist cultures (N = 232 and 237) by conducting surveys in four countries (Australia, USA, Qatar and India). Nike and Ray-Ban are the focal brands studied, with Facebook serving as the targeted social networking site (SNS) platform.

Findings
Self-monitoring and self-esteem are found to drive the self-extension tendency across cultures, with stronger effects in the individualist culture than in the collectivist culture. The self-extension tendency has a relatively stronger positive influence on social media engagement intentions in the individualist culture than in the collectivist culture. This tendency is also found to mediate the link between self-monitoring, self-extension and social media engagement intentions across both cultures, albeit in different ways. In collectivist culture, self-monitoring’s influence on the self-extension tendency is moderated by public self-consciousness. The study’s findings have important theoretical and practical implications. In individualist culture, self-monitoring’s influence on the self-extension tendency is moderated by public self-consciousness.

Research limitations/implications
The present findings confirm that the tendency to incorporate the brand into one’s self-concept and to further extend the self is indeed contingent on one’s cultural background. The role of public self-consciousness may vary between individualist and collectivist cultures, something recommended by past research for empirical testing.

Practical implications
Managers can leverage this research model to entice pro-brand social media engagement by nurturing consumers’ digital selves in terms of maneuvering their self-extension tendency and its drivers, namely, self-monitoring and self-esteem. Second, promoting the self-extension tendency and its drivers varies across cultures, with this finding offering practical cultural nuances supporting marketing managers’ decisions.

Originality/value
This is one of the pioneering studies that tests a cross-cultural parsimonious model based on theories of self-extension, self-monitoring and self-esteem, especially within the context of brand engagement intentions on an SNS platform.
Assessing the impact of knowledge management factors on digital resources acceptance: a survey of postgraduate students of public sector universities of Punjab
Authors: Ahmad Marya , Ahmad Khurshid , Bhatti Rubina 
Published: July 2023

Purpose
This study aims to measure the acceptance of digital resources by integrating knowledge management (KM) factors (i.e. acquisition, sharing, application and protection) into the factors of the technology acceptance model (TAM) (i.e. perceived ease of use and perceived usefulness) and their impact on actual system use through behavioural intention.

Design/methodology/approach
Using the quantitative research method, a survey was conducted of the public sector universities of Punjab, Pakistan. Data were collected from postgraduate students and analysed using partial least squares structural equation modelling.

Findings
The findings showed that the factors of KM with the integration of TAM significantly impact the acceptance of digital resources. The study’s hypotheses are all supported, and the findings demonstrated that knowledge acquisition, knowledge sharing, knowledge application and knowledge protection significantly influenced perceived usefulness and perceived ease of use, and that these factors are positively correlated with behavioural intentions to use digital resources.

Originality/value
This study has considerable significant implications for policymakers, developers and practitioners in designing digital resources. This study will also assist librarians to discover areas for development that may enhance the use of digital resources among users
Challenges of utilizing BIM in facilities management in Saudi Arabia
Authors: Hassanain Mohammad A. , Akbar Abdullah Ehtesham , Sanni-Anibire Muizz O. , Alshibani Adel 
Published: July 2023

Purpose
This paper aims to present an assessment of the challenges of using building information modeling (BIM) in the facilities management (FM) practice in Saudi Arabia.

Design/methodology/approach
A review of the relevant literature was conducted, resulting in identifying 31 potential challenges to BIM utilization in FM, which were grouped into five main categories. These challenges were used to design a five-point Likert scale questionnaire survey to obtain the feedback of experts in the FM domain in Saudi Arabia. The professionals that participated in the survey consisted of facilities managers, maintenance managers and BIM experts. The results obtained were analyzed based on the Effect Index (EI) approach. The questionnaire also contained an open-ended section for more qualitative data.

Findings
The results of the EI revealed that the top most influential challenges include “integration of the building systems design with BIM”, “definition of handover requirements and integration requirements between FM and BIM” and “getting appropriate and accurate information”. The category with the highest EI was the “challenges pertaining to the execution of BIM in FM”.

Practical implications
The paper outlines the critical challenges influencing the utilization of BIM in FM in Saudi Arabia and, as a result, could facilitate the development of implementation plans for BIM utilization. Thus, the study results have practical implications for stakeholders in the building industry.

Originality/value
The study contributes to the building industry through its discussion of the challenges of BIM utilization in FM and thus has the potential to increase the level of awareness of stakeholders in the industry.
Effect of acid erosion on the tribological performance of surface texture prepared with laser processing
Authors: Ji Wenzhe 
Published: July 2023

Purpose
The purpose of this study is to further improve the performance of surface texture, the chemical polishing method was introduced and the effect of it on the surface morphology and tribological properties of the surface texture was investigated.

Design/methodology/approach
The surface texture was processed on the surface of 304 stainless steel with laser technology in air medium. Hydrochloric acid solution (pH 2.4 ± 0.05) was selected and used to soak the prepared texture samples for 12 h. The surface morphology and elemental content of the samples were measured with the white light interferometry, SEM and EDS. To obtain the effect of acid corrosion on the tribological properties of textured surfaces, the samples were tested under dry friction and oil lubrication conditions.

Findings
The detailed study shows that the melt and burr of surface texture produced with laser processing was reduced due to the corrosion effect of hydrochloric acid. Therefore, the better interfacial tribological properties was obtained due to the improvement of surface-textured morphology.

Originality/value
The main contribution of this work is to provide a new reference for improving surface texture quality. It also lays a foundation for improving the tribological properties of the textured interface.

Peer review
The peer review history for this article is available at: https://publons.com/publon/10.1108/ILT-04-2023-0094/
Marketing to the sandwich generation: meeting the needs of all family members
Authors: Pak Cabrini 
Published: July 2023

Purpose
This paper aims to propose a framework for marketing to the sandwich generation (SG) shopper, an influential and growing demographic in the marketplace.

Design/methodology/approach
This paper draws from research in business, sociology, health care and industry sources that have studied the SG. It proposes a marketing framework to create value for SG shoppers and their families, in multiple ways.

Findings
SG members seek to meet at least four major kinds of needs across their intergenerational families: financial management, social support, health care and wellness. Businesses can help them more efficiently bridge those needs by including certain enablers in their offerings: human resource benefits to manage health and associated costs, resource allocation tools to manage financial and social support needs across different lifespans, time management tools to integrate social support needs with wellness outcomes and technology/services that help meet health and wellness needs across the family.

Practical implications
Managers can attract SG members and their families to their offerings by keeping in mind three rules of thumb: help them recover their most scarce resource: time; capitalize on age-friendly adjustments in the marketplace; and innovate with universal design in mind.

Originality/value
To the author’s knowledge, this is the first application of existing knowledge on the SG to a marketing framework that addresses key SG customer concerns.
Engaging employees through transformational leadership: the mediating role of emotional energy
Authors: Bao Shashan , Jolly Phillip M. 
Published: July 2023

PurposeThis study investigates the role of emotional energy as a mediator of the relationship between transformational leadership (TFL) and work engagement.Design/methodology/approachA two-wave survey was conducted through Prolific and 392 valid responses were collected from full-time hospitality and tourism employees. RStudio was used for structural equation modeling and bootstrapping analysis.FindingsResults indicate that the positive relationship between TFL and work engagement is mediated by emotional energy.Practical implicationsThe research particularly highlights to practitioners the important role of emotional energy and provides methods to improve emotional energy. Hospitality leaders should monitor the emotional energy levels of their employees and strive to avoid energy depletion. The findings also provide practitioners with some support in explaining the importance of leadership training workshops to leaders and their organizations.Originality/valueThe study provides new insight into the process underlying the TFL–work engagement relationship and highlights the importance of emotional energy as a construct of study in the hospitality industry.