bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chinese families' knowledge, attitudes, and practices regarding seizure management for children with epilepsy: a mixed-methods study
Authors: Cui Cui , Li Shuangzi , Chen Wenjin , Zhou Hengyu , Zheng Xianlan 
Published: May 2023

ObjectiveThis study aimed to examine Chinese families' knowledge, attitudes, and practices regarding the management of acute seizures (AS) that occur outside the hospital in children with epilepsy (CWE) and factors that influence AS.DesignA mixed-methods sequential explanatory study was conducted, which was integrated at the design and methods levels. In phase 1, a questionnaire was developed for this study, and a family functioning assessment was administered from Nov 2021 to Apr 2022. Multivariate logistic regression was used to analyze the knowledge, attitudes, and practices (KAP) and factors that influence AS. In phase 2, family caregivers (FCGs) were recruited from Jul to Aug 2022 to participate in a qualitative exploration, using semi-structured interviews and a combination of inductive and deductive methods.SettingThe setting was five children's specialty hospitals in different regions of China.ParticipantsThe participants were FCGs of CWE. A total of 645 participants were included in the quantitative phase, and 15 FCGs (eight parents, five grandparents, and two others) were recruited for the qualitative phase.ResultsThe FCGs' average total KAP score for AS management was 66.23 ± 15.12, with 45.42% of FCGs having a low level. Univariate and multivariate regression analyses showed that demographic factors, disease characteristics, and family function significantly predicted family management of AS. The three most salient themes and eight sub-themes from phase 2 were explored. The quantitative and qualitative databases were analyzed separately and combined through integration, and a conceptual model was constructed based on the individual and family self-management theory (IFSMT); the model consisted of context, knowledge, self-regulation, and promotion factors.ConclusionChinese families have a positive attitude toward the management of out-of-hospital AS in CWE, but lack practice and related knowledge. AS management for CWE families was associated with the demographic characteristics of FCGs, epilepsy, and family characteristics. The research findings expand the existing application requirements of an Acute Seizure Action Plan and patient safety. Our results also indicate a pressing need for localized development of AS emergency medicine in family medicine, the establishment of auxiliary information systems, the utilization of caregivers' positive psychological resources, and improvements in family function for intergenerational care.
Health outcomes and budget impact projection of anti-PD-(L)1s in cancer care in Portugal
Authors: Costa Luís , Alexandre Teresa , Mansinho André , Sousa Rita , Vieira Cláudia , Hughes Robert , Roediger Alexander , Pereira Sónia Matos , Araújo António 
Published: May 2023

IntroductionPD-[L]1 inhibitors revolutionized cancer treatment but challenge the affordability of health systems. This policy-focused model aimed to estimate the health and budget impact of anti-PD-(L)1s in Portugal and inform current discussions.Materials and methodsThe Health Impact Projection (HIP) model estimates clinical (life years, progression-free survival [PFS] years, and quality-adjusted life years [QALY] gained and adverse events [AEs] incurred) and economic (direct and indirect costs) outcomes in a world where cancer patients are initiating treatment with standard-of-care (SOC) versus SOC plus anti-PD-(L)1s over a 3-year time horizon. Indications included adjuvant and metastatic melanoma, non-small cell lung cancer (first and second line), metastatic triple-negative breast cancer, head and neck cancer, urothelial carcinoma, and renal cell carcinoma. Model inputs were based on publicly available literature data and expert opinion.ResultsThe model estimated that, over 3 years, 7,773 patients would be treated with anti-PD-(L)1s, realizing a gain of 4,787 life years, 6,901 PFS years, and 4,214 QALYs and avoiding 399 AEs. The introduction of anti-PD-(L)1s had a projected average annual impact of ≈ €108 million and a share of 20% of total cancer medicines expenditure and 0.6% of total healthcare expenditure in 2021. Although higher disease management costs are expected for patients living longer with anti-PD-(L)1s and drug acquisition costs are considerable, that is partially offset by a reduction in end-of-life costs (€611,092/year) and costs associated with patient productivity lost to cancer (€9,128,142/year).DiscussionThis model highlights the significant survival and QoL benefit of anti-PD-(L)1s for cancer patients in Portugal, with a relatively low increased cost in total healthcare expenditure.
Acute effects of mental recovery strategies in simulated air rifle competitions
Authors: Loch Fabian , Ferrauti Alexander , Meyer Tim , Pfeiffer Mark , Kellmann Michael 
Published: May 2023

ObjectivesThe present study aimed to assess the perception and change of mental and physical fatigue and to examine acute effects of mental recovery strategies in air rifle athletes across simulated competition days with two consecutive competition bouts.DesignWe conducted a randomized counterbalanced crossover study.Method22 development air rifle athletes (Mage = 17.77 ± 4.0) of a regional squad participate in the study. The Short Recovery and Stress Scale (SRSS), perception of mental fatigue, physical fatigue, concentration and motivation as well as differential Ratings of Perceived Exertion (RPE) were used to assess recovery-stress states and fatigue states. During a recovery break, participants underwent two mental recovery strategies (powernap, systematic breathing) or a control condition. Total shooting scores were recorded for both competition bouts.ResultsStudy results revealed a significant increase of post ratings for mental (p &lt; .001) and physical fatigue (p &lt; .001) for both competition bouts. The correlation coefficient between change in mental and physical fatigue for both competitions revealed a shared variance of 7.9% and 18.6%, respectively. No significant group-based acute effects of the use of mental recovery strategies on shooting performance, and psychological and perceptual measures were found. On an individual level, results illustrated statistical relevant improvements of shooting performance after powernapping or systematic breathing.ConclusionMental and physical fatigue increased and accumulated across a simulated air rifle competition and mental fatigue emerged as a separate construct from physical fatigue. The use of strategies to accelerate mental recovery on an individual level (e.g., powernap, systematic breathing) may be a first step to manage a state of mental fatigue, but further studies on mental recovery strategies in an applied setting are needed.
Effect of Cyberlindnera jadinii supplementation on growth performance, serum immunity, antioxidant status, and intestinal health in winter fur-growing raccoon dogs (Nyctereutes procyonoides)
Authors: Zhao Dehui , Zhang Haihua , Liu Keyuan , Wu Yan , Zhang Borui , Ma Cuiliu , Liu Hanlu 
Published: May 2023

IntroductionThis study aimed to investigate the effects of Cyberlindnera jadinii supplementation on the growth performance, nutrient utilization, serum biochemistry, immunity, antioxidant status, and intestinal microbiota of raccoon dogs during the winter fur-growing period.MethodsForty-five 135 (±5) day-old male raccoon dogs were randomly assigned to three dietary groups supplemented with 0 (group N), 1 × 109 (group L) and 5 × 109 CFU/g (group H) Cyberlindnera jadinii, with 15 raccoon dogs per group.ResultsThe results showed that Cyberlindnera jadinii in groups L and H improved average daily gain (ADG) and decreased feed-to-weight ratio (F/G) (P &lt; 0.05). No significant difference was found in nutrient digestibility and nitrogen metabolism among the three groups (P &gt; 0.05). Compared with group N, serum glucose levels were lower in groups L and H (P &lt; 0.05). The levels of serum immunoglobulins A and G in group L were higher than those in the other two groups (P &lt; 0.05), and the levels of serum immunoglobulins A and M in group H were higher than those in group N (P &lt; 0.05). Supplementation with Cyberlindnera jadinii in groups L and H increased serum superoxide dismutase activity, and the total antioxidant capacity in group H increased compared with group N (P &lt; 0.05). The phyla Bacteroidetes and Firmicutes were dominant in raccoon dogs. The results of principal coordinate analysis (PCoA) showed that the composition of microbiota in the three groups changed significantly (P &lt; 0.05). The relative abundance of Campylobacterota was increased in the H group compared to the N and L groups (P &lt; 0.05). The relative abundance of Sarcina was increased in group L compared with the other two groups (P &lt; 0.05), while the relative abundance of Subdoligranulum and Blautia were decreased in group H compared with the other two groups (P &lt; 0.05). Also, the relative abundance of Prevotella, Sutterella and Catenibacterium was higher in group L (P &lt; 0.05) compared with group H.DiscussionIn conclusion, dietary supplementation with Cyberlindnera jadinii improved growth performance, antioxidant activity, immune status, and improved intestinal microbiota in winter fur-growing raccoon dogs. Among the concentrations tested, 1 × 109 CFU/g was the most effective level of supplementation.
Cardiac-Adaptive Conductive Hydrogel Patch Enabling Construction of Mechanical–Electrical Anisotropic Microenvironment for Heart Repair
Authors: Song Xiaoping , Zhang Jifeng , Shen Si , Liu Dan , Zhang Jie , Yin Wenming , Ye Genlan , Wang Leyu , Cai Liu , Hou Honghao , Qiu Xiaozhong 
Published: May 2023

The biomimetic construction of a microstructural–mechanical–electrical anisotropic microenvironment adaptive to the native cardiac tissue is essential to repair myocardial infarction (MI). Inspired by the 3D anisotropic characteristic of the natural fish swim bladder (FSB), a novel flexible, anisotropic, and conductive hydrogel was developed for tissue-specific adaptation to the anisotropic structural, conductive, and mechanical features of the native cardiac extracellular matrix. The results revealed that the originally stiff, homogeneous FSB film was tailored to a highly flexible anisotropic hydrogel, enabling its potential as a functional engineered cardiac patch (ECP). In vitro and in vivo experiments demonstrated the enhanced electrophysiological activity, maturation, elongation, and orientation of cardiomyocytes (CMs), and marked MI repair performance with reduced CM apoptosis and myocardial fibrosis, thereby promoting cell retention, myogenesis, and vascularization, as well as improving electrical integration. Our findings offer a potential strategy for functional ECP and provides a novel strategy to bionically simulate the complex cardiac repair environment.
PENGARUH PEMBIAYAAN MUDHARABAH DAN PEMBIAYAAN MUSYARAKAH TERHADAP RETURN ON ASSET (ROA) PADA BANK UMUM SYARIAH (BUS) DI INDONESIA PERIODE 2017-2020
Authors: Jayengsari Reksa , Yunita Rani 
Published: May 2023

ABSTRAKPenelitian ini dilatarbelakangi oleh adanya fenomena ketidaksesuaian penurunan nilai pembiayaan dengan kenaikan tingkat ROA di Bank Umum Syariah. Penelitian ini bertujuan untuk meneliti (1) Seberapa besar pembiayaan mudharabah berpengaruh terhadap Return On Asset pada Bank Umum Syariah di Indonesia periode 2017-2020 (2) Seberapa besar pembiayaan Musyarakah berpengaruh terhadap Return On Asset pada Bank Umum Syariah di Indonesia periode 2017-2020 (3) Seberapa besar pembiayaan mudharabah dan musyarakah secara simultan berpengaruh terhadap Return On Asset pada Bank Umum Syariah di Indonesia periode 2017-2020. Pendekatan penelitian ini menggunakan pendekatan kuantitatif dengan metode penelitian deskriptif asosiatif. Teknik pengumpulan data yang digunakan adalah data sekunder bulanan yang bersumber dari SPS BUS yang dipublikasikan oleh OJK selama periode Januari 2017 sampai Desember 2020 sebanyak 48 sampel. Hasil penelitian menyimpulkan bahwa pembiayaan mudharabah tidak berpengaruh signifikan terhadap ROA dengan nilai signifikansi sebesar 0,775 > 0,05. Pembiayaan musyarakah berpengaruh signifikan terhadap ROA dengan nilai signifikansinya sebesar 0,039 < 0,05. Pembiayaan mudharabah dan pembiayaan musyarakah berpengaruh signifkan terhadap ROA, dengan nilai sig. 0,000 < 0,05. Nilai R Square sebesar 46,9% yang artinya pembiayaan mudharabah dan pembiayaan musyarakah memberikan kontribusi atau pengaruh sebesar 46,9% terhadap ROA dan sisanya sebesar 53,1% dipengaruhi oleh faktor lain di luar variabel yang diteliti.the phenomenon of discrepancy between the decrese in value of financing and increase in ROA level in Islamic Commercial Banks. This research was conducted to examine (1) How big is the mudharabah financing affect the Return On Assets in Islamic Banks in Indonesia period 2017- 2020 (2) How large Musyarakah financing affect the Return On Assets in Islamic Banks in Indonesia period 2017-2020 (3) How large financing mudharabah and musyarakah simultaneously affect the Return On Assets in Islamic Banks in Indonesia period 2017-2020. This research approach uses a quantitative approach with an associative descriptive method. Data collection techniques used are secondary data of monthly sourced from SPS BUS published by the OJK during the period from January 2017 to December 2020 as much as 48 samples. The results of the research concluded that the mudharabah financing does not affects significant impact on ROA. With the significance of 0,775 > 0.05. Musyarakah financing influential Musyarakah financing significant effect on ROA. with the significance 0.039 < 0.05. Financing mudharabah and musyarakah financing influential significantly to the ROA, with the significance 0,000 < 0.05. The value of R Square is 46.9%, which means that the financingmudharabah and musyarakah financing contribute to or influence by of 46.9% against the ROA and the rest from 53.1% influenced by other factors beyond the variables studied.
Analisis dan Perbaikan Kualitas Produk Mesin Bubut dalam Upaya Mengendalikan Tingkat Kecacatan di Industri Kertas
Authors: Azwir Hery Hamdi , Oemar Hirawati , Handa Thomas 
Published: May 2023

PT. Fajar Surya Wisesa is a leading paper producer in Indonesia that produces paper in the form of Corrugated Medium Paper (CMP), Duplex, and Kraft Liner Board (KLB). In this company there are many lathes to produce products with a high level of precision to meet the specifications requested. However, when the study was conducted, it was found that the defective product resulted from the lathe process with a fairly large percentage of 27.7%. The purpose of this study is to find the root cause of the product defect and make efforts to repair it because the defect will result in an increase in the repair process in the machining department, an increase in the raw material used for the production process, and costs. By using the PDCA method, Pareto diagrams, and fishbone diagrams, the results obtained are machines that are poorly maintained, measuring instruments that are not precise, lathes that are not durable, lack of operator training and many more. With the improvement of tools and machines, little by little the problem of product defects can be reduced and succeeded in reducing defects up to 11.70%. PT. Fajar Surya Wisesa merupakan produsen kertas terkemuka di Indonesia yang memproduksi kertas berupa Corrugated Medium Paper (CMP), Duplex, dan Kraft Liner Board (KLB). Di dalam perusahaan ini terdapat banyak mesin bubut untuk menghasilkan produk dengan tingkat presisi yang tinggi agar memenuhi spesifikasi yang diminta. Namun saat studi dilakukan ditemukan produk cacat hasil dari proses bubut tersebut dengan presentasi cukup besar yaitu 27,7%. Tujuan penelitian ini adalah untuk mencari akar masalah cacat produk tersebut dan melakukan upaya perbaikan karena adanya cacat akan berakibat meningkatnya proses repair di machining department, naiknya raw material yang digunakan untuk proses produksi tersebut, dan biaya. Dengan menggunakan metode PDCA, pareto diagram, dan fishbone diagram didapatkan hasil yaitu mesin yang kurang terawat, alat ukur yang tidak presisi, pahat bubut yang tidak awet, kurangnya training operator dan masih banyak lagi. Dengan perbaikan tools dan mesin, sedikit demi sedikit permasalahan cacat produk dapat dikurangi dan berhasil menurunkan cacat hingga mencapai 11,70%.
The Programme of the Elective Course "The Competency-Based Approach in Pharmaceutical Education as a Subject of Pedagogical Design"
Authors: Reva T. 
Published: May 2023

In the article, it has been revealed that the implementation of the competency-based approach in the system of vocational training of future specialists for the pharmaceutical sphere in modern higher education institutions (medical schools) involves aiming at the high level of development in students a set of demanded competencies required for them to qualitatively perform their professional activities.
The key objective of this article is to analyze the programme of the academic discipline (elective course), namely: "The Competency-based Approach in Pharmaceutical Education as a Subject of Pedagogical Design". In this scientific paper there have been used the methods of theoretical analysis and synthesis to consolidate the experience in designing the content of the academic discipline (elective course) "The Competency-based Approach in Pharmaceutical Education" in the settings of implementation of the European Credit Transfer System (ECTS) in the National Medical University named after O. O. Bohomolets; methods of pedagogical design for substantiation and development of contextual, operational, final-assessment program components of the mentioned academic discipline.
The author has discovered that in the process of pedagogical design of the structure of the program for the academic discipline (elective course) "The Competency-based Approach in Pharmaceutical Education" in the settings of implementation of the European Credit Transfer System (ECTS) in the training process of the students for the specialisation 226 "Pharmacy" it is important to develop the didactic complex of information supply for the academic discipline which improves the context of the topic-related workshops, the quality of the tests for evaluating educational progress of students and their self-performed work. In the feasibility study of the scientific and methodical approach to developing the Programme of the elective course studied there was decided on the development of the contextual, operational and final assessment components.
When designing the contextual component of the course there were specified its goals and objectives, selected and arranged the topics of the course with consideration of the training module.
Throughout the development of the operational component of the course there was considered the combination of different forms of educational process: workshops, self-study activities, assessment tools.
The formal manifestation of realization of the final assessment component of designing of the mentioned course there became the design of the ECTS-based assessment system for evaluation of educational progress of students, as a result of which there were chosen the following assessment tools: the ongoing written assessment (module knowledge assessment), panel and individual interviews, self-assessment and final assessment which is assigned in the final lesson with the use of tests and solving situational problems.
Using Podcasts with Students of Non-Linguistic Majors to Develop Professional Communication Competence
Authors: Sayko M. , Moroz M. , Svysiuk O. 
Published: May 2023

The article deals with the issue of updating learning materials used in ESP with students of non-linguistic universities majoring in 'Economics' and 'Management' in view of current requirements to the level of foreign language competence of job applicants.
The suggested topic is substantiated by solid research on the benefits of interdisciplinary and cross-curriculum learning materials.
The article analyzes the peculiarities of podcasts as a didactic material compared to traditional audio texts used for teaching listening, and studies the ways of using podcasts in teaching English and German to students specializing in management and economics.
Podcasts are deemed more efficient in motivating students, and developing their professional communication skills due to the key benefits they provide: topicality, autonomy, authenticity, versatility and life-to-classroom adjustment potential.
The article provides thorough analysis of websites that publish podcasts in view of their applicability for ESP. The web-resources are divided into ELT and non-ELT. ELT resources provide task sheets to each podcast, adjusted to specific language background of the learners; however, the topics are limited, and thus cannot be viewed as a substantial resource to develop an audio course of English or German. Non-ELT resources are more versatile, field-specific, and provide up-to-date information, news, expert opinion and advice on burning issues of modern economics and management. However, they are not adjusted to ESL students in their linguistic aspect and duration.
The article studies key principles of developing task sheets for podcasts to be used in teaching English and German to students majoring in economics and management.
The Use of Interactive Learning Technologies in Formation of the Professional and Legal Competence of Students in Universities of Ukraine, the European Union and the UK: a Comparative Aspect
Authors: Yashchuk S. 
Published: May 2023

Problem setting. The article deals with analysis of future social workers’ training in the context of forming students’ professional legal competency in higher education institutions of European Union (EU) and Ukraine. Based on the study of scientific and reference sources peculiarities of the educational process in the most popular higher education institutions, particularly, in EU, offering Bachelor’s and Master’s degrees in social work have been defined.
Methods. To achieve objectives of the research the following research methods were applied: analysis and synthesis of empirical and theoretical foundations that are presented in the professional literature of various scientific fields (pedagogy, psychology, training methodology etc.) in works by domestic and foreign researchers.
Results. It was found out that problem-based learning involves mastering knowledge and a plan of actions made through a problem-based way in several steps: simulation of a problem-based situation, analysis and statement of a problem, forming a hypothesis.
Conclusions. Problems of legal activity realization in the context of globalization and transformation of national legal systems, Ukraine’s integration into international and European legal space, philosophy and methodology of legal activity in higher legal education have been analyzed by T. Maslennikova, V. Ryzhykova and others. V. Hrynova, O. Ivanii, M. Podberezskyi and others have investigated legal competency of specialists. Rather perspective we consider further study of peculiarities of future social workers’ training in the context of forming students’ professional legal competency in higher education institutions of European Union (EU), the USA and