bluuebunny/crossref_metadata_2025_split huggingface dataset:
Methodological considerations in PISCES 3: a randomized, placebo-controlled study of intracerebral stem cells in subjects with disability following an ischemic stroke
Authors: Laskowitz Daniel T. , Muir Keith W. , Savitz Sean I. , Wechsler Lawrence R. , Pilitsis Julie G. , Rahimi Scott Y. , Beckman Richard L. , Holmes Vincent , Chen Peng R. , Juel Laura , Koltai Deborah , Kolls Brad J. 
Published: July 2023

Background and hypothesisAt present, there are no medical interventions proven to improve functional recovery in patients with subacute stroke. We hypothesize that the intraparenchymal administration of CTX0E03, a conditionally immortalized neural stem cell line, linked with a standardized rehabilitation therapy regimen for the upper limb, would improve functional outcomes in patients 6–12 months after an index ischemic stroke.Study designPISCES III was designed as a multicenter prospective, sham-controlled, outcome-blinded randomized clinical trial. Eligibility required a qualifying ischemic stroke 6–12 months prior to surgical intervention. Patients must be between 35 and 75 years of age and have residual moderate or moderately severe disability (mRS 3 or 4), with the preservation of some residual upper limb movement. All patients received a standardized regimen of home physical therapy following the intervention.Study outcomesThe primary outcome measure is improvement in the modified Rankin Scale (mRS) of disability at 6 months post treatment. Secondary outcomes include assessment of activities of daily living (Barthel Index), functional mobility (Timed Up and Go; Fugl Meyer Assessment), neurological impairment (NIHSS), upper limb function (Chedoke Arm and Hand Inventory), as well as patient related quality of life and global rating scales.DiscussionPISCES III was designed as a randomized trial directly comparing the effects of intraparenchymal injection of a conditional stem cell line vs. sham procedure in patients with subacute stroke. This is one of the first studies of this type to include a standardized minimum rehabilitation protocol. As there are a limited number of studies evaluating invasive stem cell administration in the chronic setting of CNS injury, study design considerations are discussed.
Molecular Characterization and Treatment Approaches for Pediatric H3 K27-Altered Diffuse Midline Glioma: Integrated Systematic Review of Individual Clinical Trial Participant Data
Authors: Damodharan Sudarshawn , Abbott Alexandra , Kellar Kaitlyn , Zhao Qianqian , Dey Mahua 
Published: July 2023

Diffuse midline glioma (DMG), H3 K27-altered are highly aggressive, incurable central nervous system (CNS) tumors. The current standard palliative treatment is radiotherapy, with most children succumbing to the disease in less than one year from the time of diagnosis. Over the past decade, there have been significant advancements in our understanding of these heterogeneous tumors at the molecular level. As a result, most of the newer clinical trials offered utilize more targeted approaches with information derived from the tumor biopsy. In this systematic review, we used individual participant data from seven recent clinical trials published over the past five years that met our inclusion and exclusion criteria to analyze factors that influence overall survival (OS). We found that the most prominent genetic alterations H3.3 (H3F3A) and TP53 were associated with worse OS and that ACVR had a protective effect. In addition, re-irradiation was the only statistically significant treatment modality that showed any survival benefit. Our findings highlight some important characteristics of DMG, H3 K27-altered and their effects on OS along with the importance of continuing to review clinical trial data to improve our therapies for these fatal tumors.
Hydrothermal Synthesis of Molybdenum Disulfide Quantum Dots for Highly Sensitive Detection of Iron Ions in Protein Succinate Oral Solution
Authors: Lang Yan , Xu Shuru , Zhang Chunbin 
Published: July 2023

In this paper, a molybdenum disulfide fluorescent probe with an Fe3+ fluorescent system was first synthesized by the hydrothermal method for the detection of iron ion concentration in oral solution of protein succinate. It was characterized by infrared, fluorescence, X-ray photoelectron spectroscopy, scanning electron microscopy, and transmission electron microscopy. The probes were found to have good stability, photobleaching, and storage stability. The effects of dilution, pH, reaction time, and iron ion concentration on the fluorescent system were also investigated. The relative fluorescence intensity [(I0 − I)/I0] showed a good linear relationship with the iron ion concentration in the range of 0–50 μM, with the linear equation [(I0 − I)/I0] = 0.0148[Fe3+] + 0.0833 (r2 = 0.9943, n = 11) and the detection limit of 2.43 μM. The reaction mechanism was also explored, as well as its ion selectivity, reversibility, accuracy, precision, and concentration of Fe ions in the actual sample. It was found that the probe can selectively detect Fe ions with a certain degree of reversibility, accuracy, precision, and ideal recovery, and it can be used for the determination of Fe3+ in proteosuccinic acid oral solution.
Hacer arte, crear espacios. Diálogos con Vicente Girardi Callafa
Authors: Girardi Callafa Vicente , Ricci Carolina Paula , Lamego Mariana 
Published: July 2023

Esta entrevista al artista y geógrafo Vicente Girardi Callafa es un ejercicio reflexivo de pensar con y a través de sus obras y sus imágenes sobre la impetuosa relación de la geografía y el arte. De acuerdo con nuestro criterio, sus obras tienen la potencia de partir desde lo diferente, lo residual, lo fragmentado para montar, creativamente, nuevos espacios tiempos. La técnica collage, preferida por el artista, nos inspira a pensar que en el arte hay muchas pistas, posibilidades y aptitudes para inspirar y producir otros pensamientos académicos. Las obras de Vicente son composiciones potentes que, desde las ruinas del mundo moderno, generan otras imaginaciones temporo-espaciales que nos interesan compartir aquí.
Pelatihan Tilawatil Quran Untuk Memperbaiki dan Memperindah Bacaan al-Quran Komunitas Muslimat NU Desa Jatiroto Kayen Pati
Authors: Luthfi M. 
Published: July 2023

Tilawatil Quran merupakan kegiatan membaguskan bacaan al-Quran sesuai dengan kaidah-kaidah yang berlaku meliputi tajwid, suara, lagu, nafas serta fashahah. Komunitas Muslimat NU Desa Jatiroto Kayen Pati dalam menyelenggaran suatu acara selalu memasukkan tilawatil Quran dalam susunan acaranya. Kader yang solid dan militan menjadi potensi tersendiri yang dimiliki oleh Muslimat NU Desa Jatiroto. Dibalik potensi tersebut Muslimat NU Desa Jatiroto masih kekurangan kader yang bisa membawakan tilawatil Quran sehingga petugas yang membawakan tilawatil Quran sangat terbatas. Pelatihan ini menjadi salah satu solusi untuk mencetak stok kader Muslimat NU Desa Jatiroto agar bisa membawakan tilawatil Quran dalam suatu acara yang diselenggarakan. Sasaran pelatihan ini adalah kader Muslimat NU Desa Jatiroto yang berminat mengikuti pelatihan. Pelaksanaan pengabdian kepada masyarakat yang berupa pelatihan ini menggunakan pendekatan Asset based comunity development (ABCD) dengan enam prosedur meliputi mengatur skenario, mengungkap masa lampau, mimpi masa depan, memetakan asset, perencanaan aksi serta evaluasi dan pembelajaran. Hasil akhir pelatihan ini terlaksana empat kali dan diikuti oleh lima kader Muslimat NU Desa Jatiroto.

Kata Kunci: Tilawatil Quran, Muslimat NU, ABCD
ANALISIS STRATEGI BERSAING APOTEK PUTER BINTARO PADA ERA COVID-19
Authors: Lestari Erika Dwi 
Published: July 2023

Virus Covid-19 yang melanda dunia pada awal tahun 2020 juga dirasakan oleh Indonesia. Akibat dari adanya Covid-19 membuat dunia kesehatan menjadi ramai, hal ini juga berdampak pada pasar farmasi di Indonesia. Adanya keramaian di pasar farmasi membuat persaingan semakin ketat. Apotek Puter Bintaro merupakan salah satu apotek konvesional yang melayani bidang kefarmasian untuk masyarakat kawasan Bintaro. Dengan ramainya pasar farmasi akibat covid-19 dan seiring berkembangnya zaman dengan munculnya apotek online, membuat Apotek Puter Bintaro harus memiliki strategi bersaing. Oleh karena itu penelitian ini bertujuan untuk mengetahui strategi bersaing yang dilakukan oleh Apotek Puter Bintari. Penelitian ini menggunakan pendekatan kualitatif deksriptif dengan teknik pengumpulan data melalui observasi, wawancara dan studi kasus. Berdasarkan hasil penelitian diketahui bahwa Apotek Puter Bintaro telah menjalankan strategi five force porter dan memilih menggunakan strategi generik pendeketan fokus kepada para konsumennya.
Influence of Knowledge of Smoking as Cancer-Causing on Behavior among Smokers
Authors: Ahram Mamoun , Alshiyyab Reem , Al Debie Ashraf , Al-Sukhni Ala’a , Shabsough Asma , Jaghbir Madi 
Published: July 2023

Background: Smoking-related behavior including passive smoking poses a major burden on the health status of populations and national economies. This is particularly true for countries that have a high prevalence of smoking like Jordan, which also has an increasing trend of waterpipe smoking: Knowledge of passive smoking and the association of knowledge of smoking as cancer-causing with quitting in addition to characteristics of smokers with denial or ignorance were assessed.
Methods: This study is part of a nationwide, cross-sectional survey conducted in Jordan. Respondents (3196) were asked about their knowledge of passive smoking in addition to the association of active, waterpipe, and passive smoking with cancer. Smokers were also asked about the possibility of them developing cancer. Knowledge and perception were correlated to past attempts and future intentions of quitting smoking. Smokers with a denial of developing cancer or lack of knowledge of the association of smoking with cancer were further characterized.
Results: Approximately half of the respondents, in general, knew of the term “passive smoking.” Knowledge of the association of smoking-related behavior with cancer was very high (~95%). However, almost 75% of smokers thought that they would develop cancer with a strong association between this perception with previous attempts or future intentions to quit smoking. Whereas smokers in their 20s and 50s, those with decreasing income, and female smokers were more likely to be in denial that they may develop cancer, male smokers and smokers in their 40s, or with intermediate education or increasing income appeared to be ignorant of the association of smoking with developing cancer.
Conclusions: These results may aid in the development of more effective and targeted anti-smoking campaigns.
Time in the Qur’an
Authors: Karic Enes 
Published: July 2023

This essay is written with the aim of presenting, in an infor-mative way, the main words of the Qur’ān relating to time or some aspect of time. The essay begins with a study of Qur’anic vocabulary on time done by Muḥammad b. Mūsā Bābāʻammī in his work Mafhūm al-Zamān fī-l-Qurʼān al-Karīm. However, in the essay we have sought to present the semantic richness of the vocabulary of the Qurʼān that relates to time. The essay can serve as a starting point for other philological, theological, and phil-osophical studies of the terminology of Islam relating to time. God created time (al-zamān).
No time existed before that. And God created place (al-makān). No place existed before that. The Absolute (al-Ḥaqq), the Magnificent, He was there although there was no place or time. He is Supreme, no place reaches Him, Nor is He owned by time!
(al-Qushayrī, Laṭāʼif al-Ishārāt, 3:145)
Evaluation of Land Suitability of Soybean, Corn and Peanuts in Kamno Sari Village, Jagebob District, Merauke Regency
Authors: Lestari Nur Aisah Cindy , Wahida Wahida 
Published: July 2023

ABSTRACT

This study aimed to determine the land suitability class for soybean, corn and peanut plants in Kamno Sari Village, Jagebob District, Merauke Regency. Data analysis was carried out by matching or compare the land requirement for plant and the properties of the land in the study area. The results of this comparison shows the land suitability level for corn, soybeans and peanuts which includes S1 (very suitable), S2 (appropriate), S3 (marginally appropriate), N1 (not suitable at this time) and N2 (not suitable permanently). The results showed that the land suitability class for soybean plants on dry land, paddy fields and land that is planned to be cleared for planting, were classified as marginal suitability class (S3) with limiting factors for root media (r), nutrient retention (f) and available nutrients (n). On the land that is planned to be cleared for planting, the limiting factor is only available nutrients (n). While forest land and open land are included in the currently unsuitable class (N1) with a limiting factor of nutrient retention (f). Land suitability class for maize on dry land, paddy fields and planned land are classified as marginal suitability class (S3) with limiting factors for nutrient retention (f) and available nutrients (n), on planned land the limiting factor is only available nutrients (n), whereas forest and open land are included in the currently unsuitable class (N1) with a limiting factor of nutrient retention (f). Land suitability class for peanut plants on dry land, paddy fields and land plans are classified as marginal suitability class (S3) with limiting factors for root media (r), nutrient retention (f) and available nutrients (n). On the land plan the limiting factor only available nutrients (n), while forest land and open land are included in currently unsuitable class (N1) with a limiting factor is nutrient retention (f).
A Study of Secondary School Students’ Attitude Towards Mathematics in Tehsil Taxila
Authors: Dr. Tooba Saleem  , Dr. Rukhsana Durrani  , Mahwish Malik  
Published: July 2023

Students' progress in mathematics is determined by their attitude toward Mathematics. A positive attitude toward a subject is a prerequisite for success in any subject. This is also true in mathematics, particularly when girls are compared to boys. This study was based on a survey of secondary school students about their attitudes towards Mathematics. This research was conducted to investigate the secondary school students’ attitude towards Mathematics. The population included the (N= 1562) students of both genders. This study was conducted on the sample of 368 students (Male=184 & Female = 184) of secondary schools from tehsil Taxila. Mathematics Attitude scale was used to collect the data. The attitude scale consists of 19 items based on 4 factors. The overall reliability of questionnaire ( =0.7452) was found appropriate. A gender wise analysis of Mathematics attitude comparison showed that female students have high anxiety and fear level as compared to male students. Finally, the current study found that females at secondary level have a lower attitude toward mathematics as compared to than males.
Keywords: Mathematics Education, Students Attitude, STEM Education, Mathematics Anxiety
Drivers and Demand for Shadow Education: A Case Study of Islamabad-Pakistan
Authors: Yousaf Sajjad , Ahmad Usman , Noor Muhammad Ehtisham 
Published: July 2023

Shadow education is a term which metaphorically denotes private tuition. The constitution of Pakistan provides for free education for children; however, their dependents (parents) along with children still pay a cost while paying fee for additionally purchased private tuition lessons. This research aims to understand the demand drivers of shadow education and its associated implicit and explicit costs in the federal capital city of Pakistan, Islamabad. The research methodology consisted of qualitative methods, semi-structured interviews, maximum variation sampling, and thematic data analysis. Parents who sent their children to both public and private schools and also opted for private tuition were considered as primary respondents. Findings showed an overall trust deficit among parents regarding public schools, classroom environment, and teachers’ attitude among which compelled them to invest in private tuition. Whereas parents who enrolled children in private schools indicated themselves as economically stable, and they had wilfully opted for private tuition for the purpose of enrichment of children learning outcomes. The differencing background between rich and poor parents showed that shadow education exacerbates social and economic inequality. In addition to that, it was also revealed shadow education carries explicit (tangible) and implicit (intangible) costs, which must be reviewed in light of article 25A of the constitution of Pakistan.
Keywords: Education, shadow education, private tuition, educational inequality, public education.
Pengembangan Formulasi Sediaan Gummy Candy dengan Variasi Konsentrasi Gelatin Sebagai Gelling Agent
Authors: Mierza Vriezka , Dwiyanti Shinta Puspa , Mulidini Mulidini , Granadha Nibullah Salsabila , Alya Abbas Zuyyinna 
Published: July 2023

Gummy candy merupakan suatu sediaan yang berbentuk lunak, terbuat dari campuran sari buah dan bahan pembentuk gel (gelling agent) serta pemanis, berwarna jernih transparan juga memiliki tekstur tertentu berdasarkan dengan kekenyalannya. Penelitian ini bertujuan untuk mengetahui formulasi dan membandingkan kadar gelatin sebagai gelling agent dalam pembentukkan tekstur kenyal sediaan gummy candy. Metode penelitian yang digunakan adalah dengan melakukan studi literatur pada beberapa jurnal yang kredibel dengan kriteria jurnal 10 tahun terakhir mengenai formulasi sediaan gummy candy dengan gelatin sebagai gelling agent-nya. Hasil yang didapatkan yaitu penggunaan gelatin sebagai gelling agent dapat dikombinasikan dengan pektin dan gliserin. Konsentrasi terbaik dari kombinasi gelatin dan pektin adalah rentang antara 15-20%, sedangkan konsentrasi terbaik dari kombinasi gelatin dan gliserin adalah dalam rentang 25-30%. Sehingga dapat disimpulkan bahwa, penggunaan gelatin sebagai gelling agent dan pektin sebagai peningkat kekenyalan membutuhkan konsentrasi yang lebih sedikit dibandingkan dengan gelatin dan gliserin untuk menghasilkan gummy candy yang memiliki tingkat kekenyalan yang disukai.
PERANCANGAN SISTEM INFORMASI PENJUALAN SUKU CADANG MOTOR DAN FITUR KELUHAN PELANGGAN BERBASIS WEB PADA PT. FUBORU INDONESIA
Authors: Rahmawati Titasari , Wirapraja Alexander , Santoso Daniel Fabio 
Published: July 2023

Perkembangan teknologi khususnya pada era industri 4.0 secara tidak langsung telah mengubah cara opersional dari suatu pekerjaan dari cara konvensional menjadi cara yang lebih praktis dan cepat, tidak terkecuali pada perusahaan manufaktur. PT. Fuboru mengalami masalah dimana pada beberapa kegiatan masih dilakukan secara manual dan adanya pandemi covid-19 sehingga menyebabkan tingkat penjualan mereka menurun. Berdasarkan pada masalah tersebut maka diperlukan optimalisasi khususnya pada bidang penjualan agar mendapatkan profit yang lebih baik. Terkait hal tersebut perlu dilakukan perancangan web e-commerce sebagai solusi mengoptimalkan penjualan produk. Metode penelitian yang digunakan adalah menggunakan metode analisis deskriptif dan menggunakan kuesioner dengan teknik pengambilan sampel menggunakan non-probability sampling untuk mendapatkan data yang diperlukan sebagai acuan mengetahui kebutuhan pengguna. Adapun metode pengembangan aplikasi yang digunakan adalah menggunakan metode waterfall, metode ini dipilih karena menyediakan urutan pengerjaan yang teratur sehingga memudahan pengembang melakukan proses perancangan dan implementasi sistem. Hasil yang didapatkan adalah aplikasi yang mampu menangani proses pemasaran sesuai dengan keinginan dan kebutuhan pengguna khususnya pada proses penjualan dan pembelian suku cadang motor. Penggunaan aplikasi ini juga mampu menyediakan pertukaran data dan informasi secara lebih baik dibandingan dengan sebelumnya. Pada situs e-commerce ini selain menangani penjualan dan pembelian juga tersedia beberapa fitur meliputi transfer stok, fitur diskon harga pada tiap produk terpilih dan fitur yang digunakan untuk menangani keluhan pelanggan terhadap produk paska pembelian hingga pada prosedur retur produk.
THREE-LEVEL HIERARCHICAL REGRESSION MODEL OF CLINKER PRODUCTION PROCESS
Authors: Щербаков А.П. 
Published: July 2023

рассматривается задача построения и оценки адекватности двухуровневой и трехуровневой иерархической регрессионной квазилинейной модели прогнозирования качества клинкера. Клинкер в цементном производстве получают обжигом сырьевой муки. Качество клинкера зависит от химического и минералогического состава сырьевой муки. Основными показателями качества являются модульные характеристики – силикатный модуль, глиноземный модуль и коэффициент насыщения. Показатели качества рассчитываются на основе химического анализа до и после обжига, то есть для исходной сырьевой муки и для клинкера. На основании имеющихся экспериментальных данных можно сделать вывод, что зависимость между показателями до и после обжига является сильно нелинейной. В данной работе нелинейная зависимость глиноземного модуля клинкера от химического состава сырьевой муки описывается с помощью иерархической квазилинейной модели. Схема построения модели имеет некоторое сходство со схемой построения интеграла Лебега, когда вместо разбиения области определения функции (как в интеграле Римана) рассматривается разбиение области значений этой функции. Адекватность построенной модели зависимости свойств клинкера от химического состава сырьевой муки подтверждается значительным снижением суммарной ошибки и приближением автокорреляционной функции остатков модели к уровню белого шума
the paper considers the problem of constructing and evaluating the adequacy of a two-level and three-level hierarchical regression quasi-linear model for predicting clinker quality. Clinker in cement production is obtained by firing raw flour. The quality of clinker depends on the chemical and mineralogical composition of the raw flour. The main quality indicators are modular characteristics – silicate module, alumina module and saturation coefficient. Quality indicators are calculated on the basis of chemical analysis before and after firing, that is, for the initial raw flour and for clinker. Based on the available experimental data, it can be concluded that the relationship between the indicators before and after firing is highly nonlinear. In this paper, the nonlinear dependence of the clinker alumina module on the chemical composition of raw flour is described using a hierarchical quasi-linear Lebesgue model. In general, such hierarchical models were defined earlier in the work of the author and co-authors. The scheme of their construction has some similarity with the scheme of constructing the Lebesgue integral, when instead of splitting the domain of definition of a function (as in the Riemann integral), the partition of the domain of values of this function is considered. The adequacy of the constructed model of the dependence of clinker properties on the chemical composition of raw flour is confirmed by a significant reduction in the total error and the approximation of the autocorrelation function of the model residues to the white noise level