bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adopting a citizen science approach in translational experimental medicine research in non-alcoholic fatty liver disease: A study protocol
Authors: Shah Syed Ghulam Sarwar , Barrado-Martín Yolanda , Marjot Thomas , Tomlinson Jeremy W. , Kiparoglou Vasiliki 
Published: May 2023

Abstract

Background Citizen science approaches are widely and successfully used in biological, environmental, and ecological sciences; however, they are rarely applied in other domains, such as translational health research, notably in the field of liver disease and metabolism. This citizen science study aims to explore the application of the citizen science approach in a translational experimental medicine experiment on non-alcoholic fatty liver disease (NAFLD) and a 12-week lifestyle and weight loss program. In this methodological paper we describe the process of involving citizen scientists in the study.Methods In his exploratory study, we will recruit a convenience sample of thirty-one participants (with and without NAFLD) and a half-dozen citizen scientists (members of public). Citizen scientists will work alongside clinical and non-clinical researchers in a translational experimental medicine study on NAFLD. Citizen scientists will be involved in the co-design and/or review of data collection tools (e.g., semi-structured open-ended questionnaire surveys and semi-structured wellbeing diaries completed by the participants), co-analysis of data on participants’ experiences and motivations, co-drafting of research findings and papers, and suggesting policy recommendations. Citizen scientists will be provided training in research tasks undertaken by them. Citizen scientists will be either co-authors or their names will be mentioned in the acknowledgements in research paper(s) based on the level of research contributions.Discussion Lessons learned from implementing citizen science in this study will help better understand the advantages and disadvantages of using citizen science in the field of translational medicine research. It will also provide insights as to how citizen science can be integrated in other translational research studies.Conclusion Involving citizen scientists in translational medicine research is important for extending research opportunities for member of the public; however, there may be methodological challenges, which may be identified and resolved by more research studies.
Promoting safe and inclusive water and sanitation services for students with physical disabilities in primary schools: a concept mapping study in Ghana
Authors: Azupogo Urbanus Wedaaba , Dassah Ebenezer , Bisung Elijah 
Published: May 2023

Abstract
Improving water, sanitation, and hygiene (WASH) services in schools is crucial to providing inclusive environments for all children to thrive. Particularly for children with disabilities, the school environment can serve as a barrier to their access to and use of WASH facilities. This paper examines strategies and programs needed to promote safe and inclusive WASH services for students with physical disabilities in primary schools in Ghana. We recruited 22 stakeholders from the Upper West Region of Ghana to complete an online concept mapping exercise. Participants identified eight themes for promoting safe and inclusive access to WASH services for students with physical disabilities. These themes included ‘building special schools,’ ‘guidance services,’ ‘ensuring non-discrimination and fair treatment,’ ‘additional programs for PWDs,’ ‘local government interventions,’ ‘public sensitization,’ ‘teacher training,’ and ‘supervision.’ These findings can assist stakeholders in identifying strategies and prioritising programs in the short run to improve WASH among students with physical disabilities.
Spatiotemporal distribution and pollution assessment of trace metals in the Buriganga River, Bangladesh
Authors: Bashar Md. Khadimull , Noro Kazushi , Wang Qi , Tokumura Masahiro , Mori Ikuko , Raknuzzaman Mohammad , Hossain Anwar , Amagai Takashi 
Published: May 2023

Abstract

The Buriganga River plays a key role in the socioeconomic structure of Dhaka, the capital of Bangladesh. However, this river is severely polluted and is considered one of the most polluted in the world. Therefore, this study aimed to assess the concentrations of various metals in the Buriganga River. A study was conducted from August 2019 to February 2020 to determine the concentrations of 16 metals in water samples (n = 210) collected from 10 distinct sites in the Buriganga River. The mean values for the concentrations of Cr, Mn, Ni, Zn, As, Se, Cd, Sb, and Pb in river water were above the guideline values prescribed by the WHO, Japan, and Bangladesh. Moreover, the fraction ratios of Be, Cr, Co, Ni, Cu, Zn, Se, Mo, Ag, Cd, Sb, and Pb were high (&gt;0.85); consequently, these metals could accumulate at high concentrations in river sediments. Assessment using the single-factor pollution index allowed the classification of the pollution level as ‘serious pollution’ for Sb and ‘heavy pollution’ for Cd, Ni, and Pb. The trace metal concentrations in this river imply that crops cultivated along the river using river water may also be contaminated with trace metals.
TERI advanced oxidation technology (TADOX®) for treatment and rejuvenation of open drains and surface water bodies: making habitats sustainable
Authors: Bahadur Nupur , Bhargava Nipun , Sarkar Shyamal Kumar , Dhawan Vibha 
Published: May 2023

Abstract
Open drains contain sewage waste and find route to surface water bodies mainly due to the absence of dedicated conveyance of wastewater to centralized wastewater treatment facilities. This poses severe environmental, public health and occupational health hazard and there is an urgent need for onsite treatment of open drains. TADOX® (TERI Advanced Oxidation Technology) from TERI (The Energy and Resources Institute, New Delhi) is an advanced approach treat drains using photocatalysis as an advanced oxidation process. This paper presents a case study of an open drain, which when treated with TADOX® Technology, improved water quality parameters meeting the regulatory norms. The untreated open drain did not meet Class E of the Water Quality Criteria laid down by the regulatory body, and attained Class A Water Quality Criteria after end-to-end treatment within 5 h. TADOX® treatment resulted in the removal of 63.5% chemical oxygen demand, 99% biochemical oxygen demand, 96% phosphate, 61% nitrogen, 3 log reduction in E. coli and 4 log reduction in total coliform values with a doubling in dissolved oxygen levels. Micropollutant load reduction of 93.5% in acetaminophen, 96% in sulfamethoxazole, 96% in ibuprofen and 89% in caffeine was also recorded in the study.
Associations between the Use of Metformin and Behavioral and Psychological Symptoms in Patients with Alzheimer´s Disease, and Type 2 Diabetes
Mellitus – A Register-based Study
Authors: Kullenberg Helena , Wibom Moa , Kumlin Maria , Nyström Thomas , Svedberg Marie M. 
Published: May 2023

Background:
Metformin, the first-line anti-diabetic drug treatment in patients with type 2
diabetes mellitus (T2DM), is suggested to be anti-inflammatory, antioxidative, and improve cognitive
function, making it a promising contribution to treating Alzheimer´s disease (AD). However, the effect
of metformin on behavioral and psychological symptoms of dementia (BPSD) in patients with AD has
not been explored.

Objective:
To investigate the associations between metformin and BPSD in patients with AD and
T2DM and explore possible interaction with other antidiabetic drugs.

Methods:
This cross-sectional study was based on data from the Swedish BPSD register. A total of
3745 patients with AD and antidiabetic drug treatment were included. Associations and interactions
between antidiabetic drugs and BPSD were investigated by binary logistic regression.

Results:
The use of metformin was associated with lower odds for symptoms of depression (OR 0.77,
CI (95%) 0.61-0.96, p = 0.022) and anxiety (OR 0.74, CI (95%) 0.58-0.94, p = 0.015) after adjustment
for age, gender, specific diagnosis, and drugs. We could not demonstrate this association with another
antidiabetic drug. Interaction effects were limited to an increasing association in eating and appetite
disorders using metformin and other antidiabetic drugs (i.e., drugs other than insulin, sulfonylurea, or
dipeptidyl peptidase-4 inhibitors).

Conclusion:
The result of this study suggests that metformin could be beneficial for patients diagnosed
with AD, other than for blood glucose control. Although, more knowledge is needed before assigning
metformin a role in treating BPSD.
Efficacy and Cost-Effectiveness Analysis of Internet-Based Cognitive Behavioral Therapy for Obsessive-Compulsive Disorder: Randomized Controlled Trial
Authors: Wu Yiwen , Li Xin , Zhou Yuxin , Gao Rui , Wang Kaifeng , Ye Huiling , Lyu Na , Wang Chun , Zhang Ning , Wang Zhen , Fan Qing 
Published: May 2023

Background
Obsessive-compulsive disorder (OCD) is a common and chronic mental illness with a high rate of disability. Internet-based cognitive behavioral therapy (ICBT) makes online treatment available to patients and has been shown to be effective. However, 3-arm trials on ICBT, face-to-face cognitive behavioral group therapy (CBGT), and only medication are still lacking.

Objective
This study is a randomized, controlled, assessor-blinded trial of 3 groups for OCD: ICBT combined with medication, CBGT combined with medication, and conventional medical treatment (ie, treatment as usual [TAU]). The study aims to investigate the efficacy and cost-effectiveness of ICBT related to CBGT and TAU for adults with OCD in China.

Methods
In total, 99 patients with OCD were selected and randomly assigned to the ICBT, CBGT, and TAU groups for treatment for 6 weeks. The primary outcomes were the Yale-Brown Obsessive-Compulsive Scale (YBOCS) and the self-rating Florida Obsessive-Compulsive Inventory (FOCI), compared at baseline, during treatment (3 weeks), and after treatment (6 weeks), to analyze efficacy. The secondary outcome was the EuroQol Visual Analogue Scale (EQ-VAS) scores of the EuroQol 5D Questionnaire (EQ-5D). The cost questionnaires were recorded to analyze cost-effectiveness.

Results
Repeated-measures ANOVA was used for data analysis, and the final effective sample size was 93 (ICBT: n=32, 34.4%; CBGT: n=28, 30.1%; TAU: n=33, 35.5%). After 6-week treatment, the YBOCS scores of the 3 groups significantly decreased (P<.001), and there were no significant differences among groups. The FOCI score of the ICBT (P=.001) and CBGT (P=.035) groups was significantly lower than that of the TAU group after treatment. The total cost of the CBGT group (renminbi [RMB] 6678.45, 95% CI 4460.88-8896.01 [US $1010.36, 95% CI 678.87-1345.84]) was significantly higher than that of the ICBT group (RMB 3308.81, 95% CI 2476.89-4140.73[US $500.58, 95% CI 374.72-626.43], P<.001) and the TAU group (RMB 2259.61, 95% CI 2074.16-2445.05 [US $341.85, 95% CI 313.79-369.90], P<.001) after treatment. The ICBT group spent RMB 303.19 (US $45.97) less than the CBGT group and RMB 11.57 (US $1.75) less than the TAU group for each unit reduction in the YBOCS score.

Conclusions
Therapist-guided ICBT combined with medication is as effective as face-to-face CBGT combined with medication for OCD. ICBT combined with medication is more cost-effective than CBGT combined with medication and conventional medical treatment. It is expected to become an efficacious and economic alternative for adults with OCD when face-to-face CBGT is not available.

Trial Registration
Chinese Clinical Trial Registry ChiCTR1900023840; https://www.chictr.org.cn/showproj.html?proj=39294
Factors Associated With Limited Cancer Health Literacy Among Chinese People: Cross-sectional Survey Study
Authors: Shan Yi , Ji Meng , Xing Zhaoquan , Dong Zhaogang 
Published: May 2023

Background
Limited cancer health literacy may be attributed to various factors. Although these factors play decisive roles in identifying individuals with limited cancer health literacy, they have not been sufficiently investigated, especially in China. There is a pressing need to ascertain the factors that effectively identify Chinese people with poor cancer health literacy.

Objective
This study aimed to identify the factor associated with limited cancer health literacy among Chinese people based on the 6-Item Cancer Health Literacy Test (CHLT-6).

Methods
We first categorized Chinese study participants according to the answers provided for cancer health literacy as follows: people who provided ≤3 correct answers were labeled as having limited cancer health literacy, whereas those who provided between 4 and 6 correct answers were labeled as having adequate cancer health literacy. We then adopted logistic regression to analyze the factors that were closely related to limited cancer health literacy among at-risk study participants.

Results
The logistic regression analysis identified the following factors that effectively predicted limited cancer health literacy: (1) male gender, (2) low education attainment, (3) age, (4) high levels of self-assessed general disease knowledge, (5) low levels of digital health literacy, (6) limited communicative health literacy, (7) low general health numeracy, and (8) high levels of mistrust in health authorities.

Conclusions
Using regression analysis, we successfully identified 8 factors that could be used as predictors of limited cancer health literacy among Chinese populations. These findings have important clinical implications for supporting Chinese people with limited cancer health literacy through the development of more targeted health educational programs and resources that better align with their actual skill levels.
The National Coordinated Citrien eHealth Program to Scale Up Telemonitoring: Protocol for a Before-and-After Evaluation Study
Authors: Gijsbers Harm , Nurmohamed Azam , van de Belt Tom H , Schijven Marlies ,   The Citrien 2 Project Leaders and Steering Group
Published: May 2023

Background
Sustainable implementation of telemonitoring in health care is challenging, especially if one aims to scale up telemonitoring initiatives nationwide. The National collaborative eHealth program in the Netherlands is supporting the nationwide upscaling of telemonitoring in 3 clinical domains by implementing telemonitoring in all Dutch university medical centers (UMCs). The chosen telemonitoring concepts are (1) telemonitoring solutions in the domain of cardiology, (2) telemonitoring solutions providing care from a distance in obstetrics, and (3) telemonitoring solutions monitoring vital functions in hospital wards.

Objective
The aim of this study is to evaluate the upscaling of telemonitoring in Dutch university hospitals in order to gain a better knowledge of the process, methods, and outcomes of nationwide upscaling strategies. Our hypothesis is that by the completion of the Citrien program’s scale-up, telemonitoring will be operational in all UMCs but not normalized in routine care.

Methods
A before-and-after study will be conducted to assess upscaling. The theoretical frameworks used are the framework for nonadoption, abandonment, scale-up, spread, and sustainability; the Normalization Process Theory; and a project management tool Project Canvas. The primary outcome of the study is the degree of normalization to which health care providers at UMCs consider telemonitoring a part of their routine practice, measured using the Normalization MeAsurement Development tool (NoMAD). Our secondary outcome is the uptake of telemonitoring at the Dutch UMCs, using management data from UMCs’ business intelligence systems query.

Results
Data will be collected between May 2020 and December 2022. Results were retrieved in June 2023. UMCs’ business intelligence systems are queried for data for the secondary outcome measures. There is a risk that the UMCs will not be able to provide this management information. The laws and regulations governing telemonitoring in the Netherlands are changing, with the Electronic Data Exchange in Health Care Act (Wet elektronische gegevensuitwisseling in de zorg) and the European Health Data Space Act expected to positively influence implementation and upscaling.

Conclusions
The Citrien program is a nationally coordinated change management program that is scaling up telemonitoring across contexts and settings. This study will produce original data on the uptake and upscaling of telemonitoring at Dutch UMCs. Future initiatives to implement eHealth in the health care sector may be guided by the wide range of success factors, obstacles, and experiences collected through this program. The network itself may be of great value impacting future acceleration of eHealth initiatives.

International Registered Report Identifier (IRRID)
DERR1-10.2196/45201
Drug management of atrial fibrillation in light of guidelines and current evidence: an Italian Survey on behalf of Italian Association of Arrhythmology and Cardiac Pacing
Authors: Diemberger Igor , Imberti Jacopo Francesco , Spagni Stefano , Rapacciuolo Antonio , Curcio Antonio , Attena Emilio , Amadori Martina , De Ponti Roberto , D’Onofrio Antonio , Boriani Giuseppe 
Published: May 2023

Aim
Atrial fibrillation is a multifaceted disease requiring personalized treatment, in accordance with current ESC guidelines. Despite a wide range of literature, we still have various aspects dividing the opinion of the experts in rate control, rhythm control and thromboembolic prophylaxis. The aim of this survey was to provide a country-wide picture of current practice regarding atrial fibrillation pharmacological management according to a patient's characteristics.

Methods
Data were collected using an in-person survey that was administered to members of the Italian Association of Arrhythmology and Cardiac Pacing.

Results
We collected data from 106 physicians, working in 72 Italian hospitals from 15 of 21 regions. Our work evidenced a high inhomogeneity in atrial fibrillation management regarding rhythm control, rate control and thromboembolic prophylaxis in both acute and chronic patients. This element was more pronounced in settings in which literature shows a lack of evidence and, consequently, the indications provided by the guidelines are weak or absent.

Conclusion
This National survey evidenced a high inhomogeneity in current approaches adopted for atrial fibrillation management by a sample of Italian cardiologist experts in arrhythmia management. Further studies are needed to explore if these divergences are associated with different long-term outcomes.
Numerical Investigation of Production-Related Characteristics Regarding their Influence on the Fatigue Strength of Additively Manufactured Components
Authors: Zeißig Michaela , Jablonski Frank 
Published: May 2023

Abstract
In order to further enhance the application of additive manufacturing (AM) processes, such as the laser powder bed fusion (L-PBF) process, reliable material data are required. However, the resulting specimen properties are significantly influenced by the process parameters and may also vary depending on the material used. Therefore, the prediction of the final properties is difficult. In the following, the effect of residual stresses on the fatigue strength of 316L steel, a commonly used steel in AM, is investigated using a Weibull distribution. The underlying residual stress distributions as a result of the building process are approximated for two building directions using finite element (FE) models. These imply significantly different distributions of tensile and compressive residual stresses within the component. Apart from the residual stresses, the impact of the mean stress sensitivity is discussed as this also influences the predicted fatigue strength values.
Identifying Factors Affecting Green Consumer Purchase Behavior on E-Commerce Websites
Authors: Noubar Hossein Bodaghi Khajeh , Holagh Sam Rahimzadeh , Sadri Arezoo 
Published: May 2023

Abstract
As ecological problems are rapidly expanding, they bring with them increasingly threatening and drastic complications. On the other hand, the economic benefits of plastic products have created a dilemma for consumers and business owners. Since one of the main channels for satisfying daily needs is online shopping and social media, and the market share of electronic commerce is growing inexorably compared to traditional brick-and-mortar methods, it would be useful to understand the factors related to consumer behavior on these platforms in order to resolve environmental issues. This research attempts to identify the factors affecting green consumer purchase decisions on social commerce platforms. A questionnaire was designed based on data gathered using bibliographic methods, and collected data from 532 valid samples was analyzed using SmartPLS software. According to the findings, subjective norms such as social network inference is positively correlated to green product attractiveness. In addition, the results show that personality traits and green product attractiveness are positively correlated; moreover, the results show that there is a positive relation between green advertising and green product attractiveness. It is believed that the outcomes of this research will contribute to and be beneficial for manufacturers and businesses by proposing a new model for green marketing and green product awareness.
The Interaction and Coupling Between Enterprise Value Evaluation and Regional Ecological Environment
Authors: Zhang Guo-Fu , Chen Xin-Ran , Li Zhi-Ren 
Published: May 2023

Abstract
The development of industrial Internet technology enterprises plays an important supporting role in green water and green mountains, as a forestry industry with both economic value and ecological value. at present, it is facing a good opportunity for development. However, industrial Internet technology enterprises are faced with many risks, such as long investment cycle, low comparative income, and their ecological value is easy to be ignored. Based on FCFF model and LINEST function, this paper studies the enterprise value evaluation and ecological development. The main conclusions are as follows: (1) the economic value of industrial Internet technology enterprises is greatly affected by non-financial factors; (2) the excess income of industrial Internet technology enterprises is affected by ecological improvement. (3) under the background of green finance, the comprehensive operation ability of enterprises can be effectively improved through internal control of enterprises, formulation of government laws and supervision of social enterprises. This study has important theoretical and practical significance for China to scientifically and reasonably evaluate the value of industrial Internet technology enterprises.