bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinic appointments and medication adherence among patients accessing mental health services in Central Malawi: A cross-sectional analytical study
Authors: Mekani Paul , Mugomeri Eltony , Mbuba Calorine Kathomi , Mbakaya Balwani Chingatichifwe 
Published: May 2023

Abstract
Background: Individuals who are non-adherent to treatment have higher rates symptom recurrence, higher hospital readmission and poor quality of life.
Methods: A cross-sectional analytical study was conducted at Nkhoma Mission Hospital, Lilongwe Malawi. Survey approach and total population sampling were used. MARS was used to assess medication adherence.
Results: The prevalence of non-adherence to clinic appointment and medication was 64% (n=58) and 46.2% respectively. Females were 4.7 times more likely to miss clinic appointments than males (B =-1.555, Exp (B)=0.221, p=0.029), clients not married were 15 times more likely not to adhere to clinic appointments (B=2.722, Exp(B)=25.12, p=0.002) and clients who visited a mobile clinic were more likely to miss appointments (B =-1.762, Exp (B)=0.172, p=0.020). Psychotic patients had a higher adherence to medication (B=1.753, t=2.041, p=0.044).
Conclusion:It is important to address factors that influence non-adherence to avoid relapse.
Bibliometric and Visualization Analysis of Research Articles on TCM’s International Spread
Authors: Xin XIONG , Xingyu Song 
Published: May 2023

Abstract
Based on 1185 research articles related to traditional Chinese medicine (TCM) from 2020 to 2023 retrieved from the Web of Science (WOS) and Scopus databases, a comprehensive systematic literature review was conducted with the primary aim of exploring the main contributors, research status, hot topics and research frontiers concerning the international spread of TCM against the COVID-19 pandemic through a metrical and visualization analysis. CiteSpace 6.1. R6 software is applied to visualize the publication countries, subjects, authors, institutes, publication sources, keywords and references of the literature and to draw a visual knowledge graph. PRISMA 2020 was used to evaluate the scientificity of this study itself, and the PRISMA 2020 scores generally showed good quality of the systematic review, conforming to 29 out of 37 items, partly in accordance with 2 items of TCM. The statistics of this study show that 81% of articles published are from China, followed by 8.2% from the USA and 5.3% from India. Moreover, the research hotspots of coronavirus in the articles involve molecular docking, sar, systematic review and herbal medicine. Moreover, the principal proposition of translation strategies in TCM’s international spread is the combination of domestication and foreignization to maintain the originality of TCM’s nature and to give consideration to the cognition of audiences. Instead of blindly merging into the Western medicine system, the international spread of TCM ought to broaden its span and to convey the theoretical framework, philosophical thoughts and traditional culture as a whole. In addition, cooperation between research institutes can be further strengthened to deliver an integrated and united research pattern.
Catalytic Reduction of 4-Nitrophenol to 4-Aminophenol Using Copper Nanoparticles on Brassica Oleracea L: Environmental Green Method
Authors: Chang Sajjad Ali 
Published: May 2023

Abstract
Rationale, Nanotechnology is the study of manipulation of material at nanoscale. At nanoscale particles exhibit unique properties like, sensor, catalytic, and antibacterial. Copper nanoparticles (Cu-NPs) were synthesized using Brassica Oleracea L. (Cabbage) extract in the current examination through an ecological green and straightforward method.
Methodology, Synthesis of Cu-NPs optimized with various parameters, for instance,
Results, temperature, time, concentration, and pH. A UV-visible spectrophotometer confirmed the formation of copper nanoparticles. Obtained spectra showed the absorption peak at 550 nm. UV-visible spectrophotometer, Energy dispersive X-Ray spectroscopy (EDX), Fourier infrared spectroscopy (FTIR), and scanning electron microscopy (SEM) was utilized to characterize the produced Cu-NPs. SEM results showed the synthesized Cu-NPs have an average size and shape. FTIR results committed the existence of functional groups at different positions. EDX spectra showed the elemental composition of extract and synthesized Cu-NPs. The biosynthesized Cu-NPs is also used as an antibacterial agent against selected pathogens like Escherichia coli, Gram-negative Pseudomonas spp, and Bacillus spp.
Discussion, The biosynthesized Cu-NPs used as a catalyst in the reduction of 4-nitrophenol into 4-aminophenol by utilizing sodium borohydride in a liquid solution and showed tremendous results. Results revealed that the Brassica Oleracea L. (cabbage) extract is effective for the synthesis of copper nanoparticles and biosynthesized copper nanoparticles used as an antibacterial agent for Bacillus spp. and a catalyst in the organic transformation of 4-Nitrophenol.
Features of the treatment of arterial hypertension in elderly patients
Authors: Leonova M. V. 
Published: May 2023

Arterial hypertension (AH) is one of the most common problems in the elderly and one of the most important cardiovascular risk factors. AH in the elderly has features with a high incidence of ISAH and is characterized by a high level of SBP and a low level of DBP, which creates certain problems for the safety of treatment. The need for antihypertensive therapy in elderly patients has received convincing evidence of the effectiveness of reducing mortality and cardiovascular complications. The purpose of this scientific review was to raise awareness of the problem of treating hypertension in elderly patients, including those with low DBP. The results of studies and meta-analyzes evaluating the efficacy and safety of standard and intensive SBP reduction in elderly patients, as well as the results of the effect of antihypertensive therapy on DBP levels, especially at baseline low DBP (<70 mmHg), are presented. The studies identified the main groups of antihypertensive drugs that provide an effective and safe reduction in blood pressure in elderly patients, have a cardioprotective effect and do not adversely affect comorbidities. These include: diuretics of the thiazide-like group, calcium channel blockers, as well as additional indications and concomitant conditions – ACE inhibitors and antigotensin II receptor blockers. Several meta-analyses have shown the benefit of intensively lowering SBP < 120 mmHg before the standard target level SBP < 140 mmHg. in elderly patients as a lower risk of fatal and non-fatal cardiovascular events and overall mortality. Thus, the impact of intensive SBP reduction was beneficial in preventing 1 case of MACE (NNT = 38) and in preventing 1 case of total mortality (NNT = 85); while the rate of harm in the form of arterial hypotension was significantly high (NNH = 778). With regard to the effect on the level of DBP in elderly patients with hypertension or ISAH, an inverse relationship between DBP and adverse coronary events was revealed and a J-curve was described, confirmed in a number of studies (INVEST, ARIC, SPRINT). Moreover, with an initially low DBP (<70 mmHg), a significant increase in the frequency of outcomes and the relative risk of outcomes was noted. It is not easy to decide on antihypertensive therapy in such situations. The evidence base of studies suggests the benefit of lowering SBP for the prevention of cardiovascular events in elderly patients, but with caution and individual approach. It is important to take into account individual patient characteristics such as cognition, autonomy, and frailty/frailty when setting target BP.
Respiratory virus concentrations in human excretions that contribute to wastewater: a systematic review and meta-analysis
Authors: Lowry Sarah A. , Wolfe Marlene K. , Boehm Alexandria B. 
Published: May 2023

Abstract

Concentrations of nucleic acids from a range of respiratory viruses in wastewater solids collected from wastewater treatment plants correlate to clinical data on disease occurrence in the community contributing to the wastewater. Viral nucleic acids enter wastewater from excretions deposited in toilets or drains. To relate measured concentrations in wastewater at a treatment plant to the number of community infections, viral nucleic-acid concentrations in human excretions are needed as inputs to a mass balance model. Here, we carried out a systematic review and meta-analysis to characterize the concentrations and presence of influenza A and B, respiratory syncytial virus, metapneumovirus, parainfluenza virus, rhinovirus, and seasonal coronaviruses in stool, urine, mucus, sputum, and saliva. We identified 220 data sets from 50 articles and reported viral concentrations and presence in these excretions. Data were unevenly distributed across virus type (with the most available for influenza) and excretion type (with the most available for respiratory excretions). Most articles only reported the presence or absence of the virus in a cross-sectional study design. There is a need for more concentration data, including longitudinal data, across all respiratory virus and excretion types. Such data would allow quantitatively linking virus wastewater concentrations to numbers of infected individuals.
Radiotherapy-associated Sensorineural Hearing Loss in Pediatric
Oncology Patients
Authors: Aslam Muhammad Ammar , Ahmad Hassaan , Malik Hamza Sultan , Uinarni Herlina , Karim Yasir Salam , Akhmedov Yusuf Makhmudovich , Abdelbasset Walid Kamal , Awadh Sura A. , Abid Mohammed Kadhem , Mustafa Yasser Fakri , Farhood Bagher , Sahebkar Amirhosein 
Published: May 2023

:
During the radiotherapeutic treatment of pediatric oncology patients, they
would be at a latent risk of developing ionizing radiation-induced ototoxicity when the
cochlea or auditory nerve is located within the radiation field. Sensorineural hearing loss
(SNHL) is an irreversible late complication of radiotherapy, and its incidence depends on
various factors such as the patient’s hearing sensitivity, total radiation dose to the cochlea,
radiotherapy fractionation regimen, age and chemoradiation. Importantly, this complication
exhibits serious challenges to adult survivors of childhood cancer, as it has been
linked to impairments in academic achievement, psychosocial development, independent
living skills, and employment in the survivor population. Therefore, early detection and
proper management can alleviate academic, speech, language, social, and psychological
morbidity arising from hearing deficits. In the present review, we have addressed issues
such as underlying mechanisms of radiation-induced SNHL, audiometric findings of pediatric
cancer patients treated with radiotherapy, and management and protection measures
against radiation-induced ototoxicity.
Redox-responsive Nanomicelles with Intracellular Targeting and Programmable
Drug Release for Targeted Tumor Therapy
Authors: Yang Yaxin , Shi Wei , Zhang Ziyi , Gong Fawu , Feng Xuman , Guo Chenxi , Qi Yajuan , Liu Zhanjun 
Published: May 2023

Introduction:
Anti-inflammatory medications, in particular aspirin, have chemopreventive
and anticancer adjuvant effects on specific types of cancers, according to ongoing anti-tumor research.
Additionally, efforts have been made to transform Poly(salicylic acid) (PSA) into delivery-related
nanocarriers. to transport anticancer medications into nanocarriers. However, tumor cell targeting and
tumor selectivity were lacking in the salicylic acid polymer-based nanocarriers, preventing them from
performing to their full potential.

Objective:
The objective of this study is to prepare targeting and reduction-responsive poly pre-drug
nanocarriers (HA-ss-PSA NPs) and to investigate the feasibility of delivering adriamycin (DOX) as
nanocarriers.

Method:
The structures of the polymers were confirmed by nuclear magnetic resonance hydrogen
spectroscopy (1H-NMR) and infrared spectroscopy (IR); the encapsulation rate and drug loading of
DOX-loaded nanoparticles were determined by HPLC; and the anti-tumor effects of the carriers were
evaluated by MTT experiments and in vivo experiments.

Results:
The prepared nanocarriers had uniform particle size distribution. The drug release rate was up to
80% within 48 h in the tumor environment. DOX/HA-ss-PSA NPs showed significant cytostatic effects. In
addition, HA-ss-PSA NPs showed significant targeting and inhibition of cell migration in cell uptake and
scratch assays. In vivo experiments showed that the prepared carriers had high tumor inhibition rates, good
targeting effects on the liver and tumor, and significantly reduced toxicity to other tissues.

Conclusion:
The prepared HA-ss-PSA NPs could effectively inhibit the growth of HepG2 cells and
tumors in vivo, indicating that PSA could be used as a backbone component of a safe and reliable drug
delivery system, providing a new strategy for the treatment of liver cancer.
A Segmentation Method of Serialized Human Body Slices based on Matting
Strategy and Skeleton Extraction
Authors: Liu Bin , Wu Zhengyang , Wang Chenlu , Pang Shiyu , Pei Jingzhu , Zhang Jianxin , Yang Liang 
Published: May 2023

Introduction::
In this paper, a semiautomatic image segmentation method for the serialized body slices of the Visible Human Project (VHP) is proposed.

Methods:
In our method, we first verified the effectiveness of the shared matting method for the VHP slices and utilized it to segment a single image. Then, to meet the need for the automatic segmentation of serialized slice images, a method based on the parallel refinement method and flood-fill method was designed. The ROI (region of interest) image of the next slice can be extracted by using the skeleton image of the ROI in the current slice.

Results:
Utilizing this strategy, the color slice images of the Visible Human body can be continuously and serially segmented. This method is not complex but is rapid and automatic with less manual participation.

Conclusion:
The experimental results show that the primary organs of the Visible Human body can be accurately extracted.
Ethnopharmacological Survey of Medicinal Plants Used by Local Herbalists and Traditional Healers for the Treatment of Cancer in Jordan
Authors: Tabaza Yahia , Aburjai Talal 
Published: May 2023

Background:As many Jordanians include herbs in their treatment, an ethnopharmacological survey was conducted to identify the most prescribed plants for the treatment of cancer by local herbalists and traditional healers in Jordan, aiming to encourage the prescription that is based on scientific evidence, to tackle some important practices in traditional healing, and to provide candidates for the isolation of new anticancer agents.Methods:Thirty-two Jordanian herbalists and traditional healers were interviewed. Both the use value and frequency of citation were implemented as quantitative methods to demonstrate the relative importance of a chosen species for the treatment of cancer. Furthermore, literature was screened for evidences that supported or opposed the use of the plants of interestResults:It was revealed that 31 plants are currently used in Jordan for the treatment of cancer, with Curcuma longa and Ephedra foeminea being the most used ones.Conclusions:It was noticed that the use of many prescribed plants could be rationalised by in vitro and/or in vivo studies. However, more attention should be paid by practitioners to some important aspects, such as the method of use and preparation of plants, their interaction with chemotherapeutic agents and the differences in their efficacy against different cancer types.
Tingkat pemahaman siswa kelas V terhadap pembelajaran permainan net menggunakan media video di Sekolah Dasar
Authors: Listyarini A Erlina , Ali Jaka Sayidina 
Published: May 2023

Abstrak: Penelitian ini bertujuan untuk mengetahui tingkat pemahaman siswa kelas V terhadap pembelajaran permainan net menggunakan media video di SD Negeri se-Dabin I Kecamatan Ngombol Kabupaten Purworejo. Penelitian ini merupakan penelitian deskriptif kuantitatif dengan metode pendekatan survei. Populasi dalam penelitian ini adalah seluruh siswa kelas V di SD Negeri se-Dabin I Kecamatan Ngombol Kabupaten Purworejo dengan jumlah 70 siswa. Instrumen yang digunakan adalah tes pilihan ganda. Hasil uji coba validitas instrumen menunjukan 30 butir soal dinyatakan valid. Uji reliabilitas instrumen menggunakan rumus Alpha Cronbach’s sebesar 0,872. Teknik analisis data yang digunakan adalah dengan persentase. Hasil penelitian menunjukkan bahwa tingkat pemahaman siswa kelas V terhadap pembelajaran permainan net menggunakan media video di SD Negeri se-Dabin I Kecamatan Ngombol Kabupaten Purworejo dengan kategori sangat tinggi dengan frekuensi 19 siswa (27,14%), tinggi dengan frekuensi 17 siswa (24,23%), sedang dengan frekuensi 22 siswa (31,43%), rendah dengan frekuensi 10 siswa (14,30%), dan sangat rendah dengan frekuensi 2 siswa (2,90%). Abstract: This research aims to determine the level of comprehension of the fifth grade students on the learning net games using video media in the elementary schools located in Cluster 1, Ngombol District, Purworejo Regency.This research was a descriptive quantitative study with a survey approach method. The research population was all fifth grade students in the elementary schools located in Cluster 1 Ngombol District, Purworejo Regency with a total of 70 students. The research instrument was a multiple choice test. The results of the test of the validity of the instrument showed that 30 items were declared valid. The instrument reliability test used Cronbach's Alpha formula of 0.872. The data analysis technique used the percentage analysis.The results show that the level of comprehension of fifth grade students towards the learning net games using video media in elementary schools located in Cluster 1, Ngombol District, Purworejo Regency is as follows: in the very high level with a frequency of 19 students (27.14%), in the high level with a frequency of 17 students (24.23%), in the medium level with a frequency of 22 students (31.43%), in the low level with a frequency of 10 students (14.30%), and in the very low level with a frequency of 2 students (2.90%).
Fyodor Lukich Pereverzev in Opposition to the Drinking Reforms in Russia (late 1850s – early 1860s)
Authors: Goryushkina N. E. 
Published: May 2023

Relevance. The article is devoted to the director of the Department of Various taxes and Fees of the Ministry of Finance of Russia in the late 1850s - early 1860s, Fyodor Lukich Pereverzev, who was opposed to the planned wine reform. The plot of the article was not covered in the scientific literature, but it is essential to create a complete picture of the excise transformation.The purpose of the article is to recreate the image of a high official of the finance Ministry, who prevented the transition from tax payments to the excise system of levying a tax on drinking.Objectives: to give a description of Pereverzev's official activity; to establish the circumstances that determined his position regarding drinking; to describe the essence of classes in the Special Committee for the Development of Wine Reform.Methodology. The principles of scientific objectivity and historical anthropologism became the basis for the study of the stated topic. In addition, a personal biographical method was used, which allowed through acquaintance with the biography of Pereverzev to explain his position on the wine reform.Results. Pereverzev's career path was long, he proved himself both in the military and in the civilian field. The peak of his official career was the post of director of the Department of Various Taxes and Fees. In this position, Fyodor Lukich was included in the Special Committee for the Development of Wine Reform. His work was fruitless, the reform plan was not prepared.Conclusion. Pereverzev was in opposition to the drinking transformation, since he considered the payoff a proven way of collecting a fee from drinking, and the excise tax a system that requires a long check. He was a staunch follower of E.F. Kankrin and believed that the excise system was good for the West, but not suitable for Russia.
Higher Educational Institutions of the Musical Profile in the Volga Region in the Second half of the 1930s – 1950s: Problems of Personnel Support
Authors: Suetin I. N. 
Published: May 2023

Relevance. The state policy of most countries of the world is aimed at increasing the qualitative level and competitiveness of domestic education systems, the development of individual industries in the field of education. Positive changes in this area can help studying the historical experience of building national education models, the use of domestic educational traditions of the past in modern practice.The purpose of the study is to cover and popularize approaches to ensure the staff of the superior musical and educational institutions in the Volga region in the second half of the 1930s-the 1950s.The objectives of the study: to study factual material reflecting the ways of solving personnel problems in domestic conservatories in the second half of the 1930s – 1950s; identify the degree of effectiveness of this activity.Methodology. In the course of the study, the following sources were used: scientific articles, dissertations, collections of documents, archive materials. The methodological basis of the work was the principles of objectivity and comprehensiveness, as well as a number of scientific methods: system analysis, historical, typological, historical and comprehensive.Results. As a result of this study, approaches to the personnel support of the musical higher educational institutions of the Volga region in the second half of the 1930s-1950s were specified.Conclusion. The study showed that in the conditions of modernization development of the second half of the 1930s and 1950s, due to migration processes, the problem of personnel recruitment of musical universities (conservatives) was effectively solved in the Volga region. The decisive role in this issue belonged to the state system of distribution of specialists. Capital musicians (Moscow, Leningrad, etc.), evacuated to the region during the Great Patriotic War, played key importance for replenishing and strengthening the states of the Volga conservatory. Thanks to the shots involved during this period, musical and cultural traditions were formed, pedagogical and performing regional schools were created, several generations of professional musicians were brought up.