bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factor Analysis Investigating the Efficacy of HP-3070 Transdermal System in Positive and Negative Syndrome Scale Five Adults With Schizophrenia
Authors: Citrome Leslie , Castelli Mariacristina , Byreddy Sandeep , Hasebe Masami , Terahara Takaaki , Faden Justin , Komaroff Marina 
Published: April 2023

AbstractIntroductionHP-3070, a once-daily asenapine transdermal system, is FDA-approved for adults with schizophrenia. In a pivotal phase 3 randomized controlled study, patients with schizophrenia who were treated once daily with HP-3070 demonstrated significant improvement in Positive and Negative Syndrome Scale (PANSS) total scores compared with placebo. The PANSS score’s five-factor structure can also assess treatment efficacy across different domains. This post-hoc analysis of the pivotal study evaluated the efficacy of HP-3070 by examining these domains.MethodsIn the pivotal phase 3 study, adults with acute exacerbations of schizophrenia were randomized to 6 weeks of treatment with HP-3070 3.8mg/24h, 7.6mg/24h, or placebo. Factor analysis of PANSS scores was performed using five domains (negative symptoms, positive symptoms, disorganized thought, uncontrolled hostility/excitement, anxiety/depression). Mixed-model repeated-measures (MMRM) analysis included change from baseline in PANSS factor score as the repeated dependent variable, with country, treatment, visit, treatment by visit interaction, and baseline PANSS score as covariates.ResultsThe analysis included 607 patients. Least-squares mean estimates (standard error) of the difference from placebo in change from baseline to Week 6 for each factor were as follows: negative symptoms, 3.8mg/24h, -0.9 (0.43), P=0.045, and 7.6mg/24h, -0.4 (0.43), P=0.41; positive symptoms, 3.8mg/24h, -2.3 (0.57), P<0.001, and 7.6mg/24h, -2.0 (0.57), P<0.001; disorganized thought, 3.8mg/24h, -1.5 (0.38), P<0.001, and 7.6mg/24h, -0.9 (0.38), P=0.03; uncontrolled hostility/excitement: 3.8mg/24h, -1.1 (0.30), P<0.001, and 7.6mg/24h -0.9 (0.30), P=0.002; anxiety/depression, 3.8mg/24h, -0.5 (0.31), P=0.14, and 7.6mg/24h, -0.6 (0.31), P=0.07.ConclusionsHP-3070 demonstrated treatment effects on a PANSS five-factor model, with the results indicating impact on negative symptoms, positive symptoms, disorganized thought, uncontrolled hostility/excitement, and anxiety/depression. These findings suggest that HP-3070 may address a broad range of symptoms in schizophrenia.FundingNoven Pharmaceuticals, Inc., a wholly-owned subsidiary of Hisamitsu Pharmaceutical, Co.
New Onset Capgras and Cotard Delusions in Schizoaffective Disorder
Authors: Ongchuan Samantha , Munjal Sahil 
Published: April 2023

AbstractBackgroundCotard is a syndrome characterized by ideas of damnation or rejection, anxious melancholia, and nihilistic delusions concerning one’s own body or existence. Capgras is a syndrome in which the patient believes that the identities of close relatives or friends are replaced by others. Capgras and Cotard delusion are rarely reported in one individual simultaneously, which we will describe in this poster.Case ReportDD is a 38-year-old female with history of schizoaffective disorder, bipolar type, PTSD, and reported TBI who presented to the ED exhibiting paranoia and delusions in the setting of medication non-adherence and increased psychosocial stressors. She endorsed her organs were rotting, and that she was stolen by imposters who claim to be her family from birth. Chart review revealed previous hospitalizations involving mania and paranoid delusions; however, these Cotard and Capgras delusions were new. She also had reported TBI injury from domestic abuse, as well as emotional and sexual trauma. Her Cotard delusions resolved with risperidone 6 mg daily and valproic acid 500 mg BID. However, her Capgras delusions were maintained after 22 days of inpatient hospitalization. On discharge, she continued to refuse reconnecting with her family and was subsequently set up with an intensive outpatient program.DiscussionCotard and Capgras delusions are considered to reflect different interpretations of similar anomalous experiences. The persecutory delusions and suspiciousness often noted in Capgras contribute to the patient’s mistaking a change in themselves for a change in others, whereas people who are depressed in Cotard exaggerate the negative effects of the same change whilst attributing it to themselves. Although these two delusions are phenomenally distinct, they may therefore represent attempts to make sense of fundamentally similar experiences. The anatomical origin of these disorders have been reported to be from a disconnection between the temporal cortex and the limbic system as described in a patient with ischemic stroke. DD’s PTSD and TBI with possible damage to her left tempoparietal lobe may have predisposed her to comorbid delusions. Although DD’s Cotard delusions abated with antipsychotic treatment, her Capgras delusions were maintained. Recently losing custody of children may have contributed to the depression that precipitated her Cotard subtype 1 delusion. Her response to risperidone is consistent with a previous case report that highlighted the effectiveness of antipsychotics in the absence of ECT with Cotard delusion. In regards to her ongoing Capgras delusion, the chronic abuse by DD’s family may have led to a more persistent psychodynamically meaningful negation of DD’s sense of relationship to her family.ConclusionCapgras and Cotard syndromes, though rare, can present together. Additional studies are needed to understand the pathophysiology and treatment outcomes.FundingNo Funding
Soil Respiration Responses to Throughfall Exclusion Are Decoupled From Changes in Soil Moisture for Four Tropical Forests, Suggesting Processes for Ecosystem Models
Authors: Cusack Daniela F. , Dietterich Lee H. , Sulman Benjamin N. 
Published: April 2023

AbstractClimatic drying is predicted for many tropical forests yet models remain poorly parameterized for these ecosystems, hampering predictions of forest‐climate interactions. We applied an integrated model–experiment approach, parameterizing an ecosystem model with tropical forest observational data and comparing model predictions to a field drying manipulation. We hypothesized that drying suppresses soil CO2 fluxes (i.e., respiration) in relatively dry tropical forests but increases CO2 fluxes in wetter tropical forests by alleviating anaerobiosis. We measured soil CO2 fluxes during wet‐dry cycles from 2015 to 2022 in four Panamanian forests that vary in rainfall and soil fertility. Measured soil CO2 fluxes declined in the dry season and peaked in the early wet season ahead of peak soil moisture, resulting in lower soil moisture optima for respiration than previously modeled. We then parameterized the model using field data and the new moisture‐respiration response functions. The updated model predicted increased soil CO2 fluxes with drying in wetter and fertile forests and suppressed fluxes in drier, infertile forests. In contrast to model predictions, a chronic throughfall exclusion experiment initially suppressed soil respiration across forests, with sustained suppression for four years in the wettest forest only (−28% ± 4% during the dry season). In the fertile forest, drying eventually elevated CO2 fluxes over this period (+75% ± 28% during the late wet season). The unexpected negative drying effect in the wettest, infertile forest could have resulted from reduced vertical flushing of nutrients into soils. Including hydro‐nutrient interactions in ecosystem models could improve predictions of tropical forest‐climate feedbacks.
Reply to “Comment on Ionospheric and Magnetic Signature of a Space Weather Event on August 2018: CME and HSSWs by Kader et al. (2023)”
Authors: Younas Waqar , Khan Majid , Ammory‐Mazaudier C. , Fleury R. 
Published: April 2023

AbstractWe agree with Kader et al. (2023, https://doi.org/10.1029/2022ja030701) to the extent that longitudinal axis was flipped, by mistake, in Figure 5a of Younas et al. (2020, https://doi.org/10.1029/2020ja027981). However, claiming that this leads to wrong interpretation of main finding of the work is not true. This only affects one sentence in the Result section of Younas et al. (2020, https://doi.org/10.1029/2020ja027981). Moreover, the claimed corrected figure of Kader et al. (2023, https://doi.org/10.1029/2022ja030701) still has a scaling error which may lead to wrong interpretation of GUVI data. For setting a benchmark for future studies, we propose that either scaling should not be done, or it must be the same for all the considered days. Moreover, Kader et al. (2023, https://doi.org/10.1029/2022ja030701) showed that by taking mean of data points leads to different results, which is possible however it cannot be considered as an error in our work. If they believe that their method gives better explanation, they should publish it as an independent article. The statement of Kader et al. (2023, https://doi.org/10.1029/2022ja030701) about the error in our TEC data is also exaggerated. The article by Bolaji et al. (2021, https://doi.org/10.1029/2020ja029068) provided more insight about latitudinal variations in two sectors and used different GPS stations. Obviously, it is not possible to put all data sets in one study. Hence, stating that Bolaji et al. (2021, https://doi.org/10.1029/2020ja029068) found errors in our TEC results is a misleading statement. Although Kader et al. (2023, https://doi.org/10.1029/2022ja030701) also pointed out an error in Bolaji et al. (2021, https://doi.org/10.1029/2020ja029068), however in their title they only comment about Y20.
Stabilization of mineral-associated organic carbon in Pleistocene permafrost
Authors: Martens Jannik , Mueller Carsten W. , Joshi Prachi , Rosinger Christoph , Maisch Markus , Kappler Andreas , Bonkowski Michael , Schwamborn Georg , Schirrmeister Lutz , Rethemeyer Janet 
Published: April 2023

AbstractIce-rich Pleistocene-age permafrost is particularly vulnerable to rapid thaw, which may quickly expose a large pool of sedimentary organic matter (OM) to microbial degradation and lead to emissions of climate-sensitive greenhouse gases. Protective physico-chemical mechanisms may, however, restrict microbial accessibility and reduce OM decomposition; mechanisms that may be influenced by changing environmental conditions during sediment deposition. Here we study different OM fractions in Siberian permafrost deposited during colder and warmer periods of the past 55,000 years. Among known stabilization mechanisms, the occlusion of OM in aggregates is of minor importance, while 33-74% of the organic carbon is associated with small, <6.3 µm mineral particles. Preservation of carbon in mineral-associated OM is enhanced by reactive iron minerals particularly during cold and dry climate, reflected by low microbial CO2production in incubation experiments. Warmer and wetter conditions reduce OM stabilization, shown by more decomposed mineral-associated OM and up to 30% higher CO2production. This shows that considering the stability and bioavailability of Pleistocene-age permafrost carbon is important for predicting future climate-carbon feedback.
Screening of Drosophila microRNA-degradation sequences reveals Argonaute1 mRNA’s role in regulating miR-999
Authors: Sheng Peike , Li Lu , Li Tianqi , Wang Yuzhi , Hiers Nicholas M. , Mejia Jennifer S. , Sanchez Jossie S. , Zhou Lei , Xie Mingyi 
Published: April 2023

AbstractMicroRNAs (miRNA) load onto AGO proteins to target mRNAs for translational repression or degradation. However, miRNA degradation can be triggered when extensively base-paired with target RNAs, which induces confirmational change of AGO and recruitment of ZSWIM8 ubiquitin ligase to mark AGO for proteasomal degradation. This target RNA-directed miRNA degradation (TDMD) mechanism appears to be evolutionarily conserved, but recent studies have focused on mammalian systems. Here, we performed AGO1-CLASH in Drosophila S2 cells, with Dora (ortholog of vertebrate ZSWIM8) knockout mediated by CRISPR-Cas9 to identify five TDMD triggers (sequences that can induce miRNA degradation). Interestingly, one trigger in the 3′ UTR of AGO1 mRNA induces miR-999 degradation. CRISPR-Cas9 knockout of the AGO1 trigger in S2 cells and in Drosophila specifically elevates miR-999, with concurrent repression of the miR-999 targets. AGO1 trigger knockout flies respond poorly to hydrogen peroxide-induced stress, demonstrating the physiological importance of this TDMD event.
Obesity, but not high-fat diet, is associated with bone loss that is reversed via CD4+CD25+Foxp3+ Tregs-mediated gut microbiome of non-obese mice
Authors: Song Wei , Sheng Qinglin , Bai Yuying , Li Li , Ning Xin , Liu Yangeng , Song Chen , Wang Tianyi , Dong Xiaohua , Luo Yane , Hu Jinhong , Zhu Lina , Cui Xiaole , Chen Bing , Li Lingling , Cai Congli , Cui Haobo , Yue Tianli 
Published: April 2023

AbstractOsteoporosis is characterized by decreased bone mass, microarchitectural deterioration, and increased bone fragility. High-fat diet (HFD)-induced obesity also results in bone loss, which is associated with an imbalanced gut microbiome. However, whether HFD-induced obesity or HFD itself promotes osteoclastogenesis and consequent bone loss remains unclear. In this study, we developed HFD-induced obesity (HIO) and non-obesity (NO) mouse models to evaluate the effect of HFD on bone loss. NO mice were defined as body weight within 5% of higher or lower than that of chow diet fed mice after 10 weeks HFD feeding. NO was protected from HIO-induced bone loss by the RANKL /OPG system, with associated increases in the tibia tenacity, cortical bone mean density, bone volume of cancellous bone, and trabecular number. This led to increased bone strength and improved bone microstructure via the microbiome-short-chain fatty acids (SCFAs) regulation. Additionally, endogenous gut-SCFAs produced by the NO mice activated free fatty acid receptor 2 and inhibited histone deacetylases, resulting in the promotion of Treg cell proliferation in the HFD-fed NO mice; thereby, inhibiting osteoclastogenesis, which can be transplanted by fecal microbiome. Furthermore, T cells from NO mice retain differentiation of osteoclast precursors of RAW 264.7 macrophages ex vivo. Our data reveal that HFD is not a deleterious diet; however, the induction of obesity serves as a key trigger of bone loss that can be blocked by a NO mouse-specific gut microbiome.
Modulation of internal solitary waves by the Kuroshio in the northern South China Sea
Authors: Yu Yujun , Chen Xu , Cao Anzhou , Meng Jing , Yang Xiaoxin , Liu Tianyang 
Published: April 2023

AbstractInternal solitary waves (ISWs) in the South China Sea (SCS) are considerably modulated by the background currents. In this study, a three-dimensional high-resolution non-hydrostatic model is configured to investigate how the Kuroshio influences the generation and evolution of ISWs in the northern SCS. Three runs are conducted, including one control experiment without the Kuroshio and two sensitivity experiments with the Kuroshio in different paths. In the Luzon Strait (LS), the Kuroshio reduces the westward baroclinic energy flux radiated into the SCS, resulting in weakened ISWs. In the SCS basin, the background currents further refract the ISWs. With the leaping Kuroshio, the A-waves have longer crest lines but lower amplitudes compared with those in the control run. In contrast, the B-waves are less affected by the leaping Kuroshio. In the presence of looping Kuroshio, the wave refraction caused by the intrusion currents in the SCS basin results in the weakest amplitudes and energy but the widest crest lines of ISWs. Moreover, the energy of the A-waves exhibits double-peak structure along the crest lines. The crest lines of the B-waves extend to 19.5° N, which are more south than those in summer. These results highlight the importance of the Kuroshio on the 3D features of ISWs in the SCS.
Effect of bioagents on cucumber seed mycoflora, seed germination, and seedling vigour
Authors: Sharma Aman , Shukla Arti , Gupta Meenu 
Published: April 2023

AbstractThe effect of different bioagents such as Trichoderma harzianum, T. viride, T. virens, Pseudomonas fluorescens, and Bacillus subtilis was studied on seed mycoflora, seed germination, root/shoot length, and seedling vigour of cucumber var. Solan Srijan under in vitro conditions. Alternaria sp., Aspergillus sp., and Fusarium spp. were observed on cucumber as seed mycoflora, with T. harzianum showing the greatest inhibition for Alternaria sp. and Fusarium spp., and T. viride showing the greatest inhibition for Aspergillus sp. Cucumber var. Solan Srijan seeds were treated with various bio agents, with T. harzianum being the most effective in increasing seed germination (88.75%), root length (13.58 cm), shoot length (14.58 cm), and seedling vigour (2501.31).
Bio-catalytic degradation of dibenzothiophene (DBT) in petroleum distillate (diesel) by Pseudomonas spp.
Authors: Sadare Olawumi Oluwafolakemi , Daramola Michael Olawale 
Published: April 2023

AbstractBiodesulfurization (BDS) was employed in this study to degrade dibenzothiophene (DBT) which accounts for 70% of the sulfur compounds in diesel using a synthetic and typical South African diesel in the aqueous and biphasic medium. Two Pseudomonas sp. bacteria namely Pseudomonas aeruginosa and Pseudomonas putida were used as biocatalysts. The desulfurization pathways of DBT by the two bacteria were determined by gas chromatography (GC)/mass spectrometry (MS) and High-Performance Liquid Chromatography (HPLC). Both organisms were found to produce 2-hydroxy biphenyl, the desulfurized product of DBT. Results showed BDS performance of 67.53% and 50.02%, by Pseudomonas aeruginosa and Pseudomonas putida, respectively for 500 ppm initial DBT concentration. In order to study the desulfurization of diesel oils obtained from an oil refinery, resting cells studies by Pseudomonas aeruginosa were carried out which showed a decrease of about 30% and 70.54% DBT removal for 5200 ppm in hydrodesulfurization (HDS) feed diesel and 120 ppm in HDS outlet diesel, respectively. Pseudomonas aeruginosa and Pseudomonas putida selectively degraded DBT to form 2-HBP. Application of these bacteria for the desulfurization of diesel showed promising potential for decreasing the sulfur content of South African diesel oil.
Exploiting social graph networks for emotion prediction
Authors: Khalid Maryam , Sano Akane 
Published: April 2023

AbstractEmotion prediction plays an essential role in mental healthcare and emotion-aware computing. The complex nature of emotion resulting from its dependency on a person’s physiological health, mental state, and his surroundings makes its prediction a challenging task. In this work, we utilize mobile sensing data to predict self-reported happiness and stress levels. In addition to a person’s physiology, we also incorporate the environment’s impact through weather and social network. To this end, we leverage phone data to construct social networks and develop a machine learning architecture that aggregates information from multiple users of the graph network and integrates it with the temporal dynamics of data to predict emotion for all users. The construction of social networks does not incur additional costs in terms of ecological momentary assessments or data collection from users and does not raise privacy concerns. We propose an architecture that automates the integration of the user’s social network in affect prediction and is capable of dealing with the dynamic distribution of real-life social networks, making it scalable to large-scale networks. The extensive evaluation highlights the prediction performance improvement provided by the integration of social networks. We further investigate the impact of graph topology on the model’s performance.
Quantum annealing for microstructure equilibration with long-range elastic interactions
Authors: Sandt Roland , Le Bouar Yann , Spatschek Robert 
Published: April 2023

AbstractWe demonstrate the use and benefits of quantum annealing approaches for the determination of equilibrated microstructures in shape memory alloys and other materials with long-range elastic interaction between coherent grains and their different martensite variants and phases. After a one dimensional illustration of the general approach, which requires to formulate the energy of the system in terms of an Ising Hamiltonian, we use distant dependent elastic interactions between grains to predict the variant selection for different transformation eigenstrains. The results and performance of the computations are compared to classical algorithms, demonstrating that the new approach can lead to a significant acceleration of the simulations. Beyond a discretization using simple cuboidal elements, also a direct representation of arbitrary microstructures is possible, allowing fast simulations with currently up to several thousand grains.
Fabrication of spectroscopic microfluidic chips for mastitis detection in raw milk
Authors: Phiphattanaphiphop Chalinee , Leksakul Komgrit , Nakkiew Wasawat , Phatthanakun Rungrueang , Khamlor Trisadee 
Published: April 2023

AbstractMastitis is a disease that directly affects the quantity and quality of milk produced by dairy cows, which can have a negative impact on the income generated from selling the milk. Severe inflammation caused by this mammary disease can result in up to 1 × 106 white blood cells per milliliter of cow milk. Currently, the California mastitis test is a popular chemical inspection test, but its error rate of over 40% is a significant factor in the ongoing spread of mastitis. In this study, a new microfluidic device was designed and fabricated to identify normal, sub-clinical, and clinical mastitis. This portable device allows for precise and analysis of results within a second. The device was designed to screen somatic cells and a staining process was added to identify somatic cells using single-cell process analysis. The fluorescence principle was used to identify the infection status of the milk, which was analyzed using a mini-spectrometer. The accuracy of the device was tested, and it was found to determine the infection status with 95% accuracy, compared to the accuracy obtained using the Fossomatic machine. By introducing this new microfluidic device, it is believed that the spread of mastitis in dairy cows can be significantly reduced, leading to higher quality and more profitable milk production.