bluuebunny/crossref_metadata_2025_split huggingface dataset:
A feedback loop comprising E2F1, MYC and SNHG15 interplays with HNRNPA1/SLC7A11/GPX4 pathway to promote gastric cancer progression
Authors: Duan Yantao , Li Kun , Dou Yi , Fu Hongbing , Dong Yang , Wang Yu , Huang Binhao , Kang Wei , Wei Gong-Hong , Cai Qiliang , Xu Dazhi 
Published: February 2023

Abstract
Background: Dysregulation of long non-coding RNAs (lncRNAs) expression plays pivotal roles in the initiation and progression of gastric cancer (GC). However, the regulation of lncRNA SNHG15 in GC has not been well studied. Mechanisms for ferroptosis by SNHG15 have not been revealed. Here, we aimed to explore SNHG15-mediated biological functions and underlying molecular mechanisms in GC progression.
Methods: The novel SNHG15 was identified by analyzing RNA-sequencing (RNA-seq)data of GC tissues from our cohort and TCGA dataset, and further validated by qRT-PCR in GC cells and tissues. Gain- and loss-of-function assays were performed to examine the role of SNHG15 on GC both in vitro and in vivo. The regulatory mechanisms of SNHG15 were investigated by bioinformatics, RNA FISH, luciferase reporter assay, chromatin immunoprecipitation (ChIP), RNA pull-down, RIP-qPCR and luciferase assays.
Results: SNHG15 was highly expressed in GC. The enhanced SNHG15 was positively correlated with malignant stage and poor prognosis in GC patients. Gain- and loss-of-function studies showed that SNHG15 was required for affecting cell growth, migration and invasion both in vitro and in vivo. Mechanistically, the oncogenic transcription factors E2F1 and MYC could bind to the SNHG15 promoter and enhanced its expression. Meanwhile, SNHG15 increased E2F1 and MYC mRNA expression by sponging miR-24-3p. Notably, SNHG15 could also enhance the stability of SLC7A11 in cytoplasm by competitively binding HNRNPA1. In addition, SNHG15 inhibited ferroptosis through a HNRNPA1-dependent regulation of SLC7A11/GPX4 axis.
Conclusions: Our results support a novel model in which E2F1- and MYC-activated SNHG15 regulates ferroptosis via HNRNPA1-dependent modulation of SLC7A11/GPX4 axis serves as the critical effectors in GC progression, providing a new therapeutic direction in the treatment of GC.
Dynamics of Resonant Curves of Earth-Moon system under the influence of Resistive Force using Unperturbed Solution
Authors: Yadav Sushil , Kumar Virendra , Aggarwal Rajiv , Kaur Bhavneet 
Published: February 2023

Abstract
This work investigates the dynamical behavior of the resonant curves in the motion of the Earth-Moon system under the influence of resistive force. In this study, the resonance arises in this motion due to the rate of change of Earth’s equatorial ellipticity (EEE) (˙ γ), the Moon’s angular velocity (˙ θmo) around the Earth, and angular velocity of barycenter (˙ α0) around the Sun, including the coefficient of resistive force (b). The configuration and equations of motion are expressed in a spherical coordinate system using the Earth’s potential. Applying the unperturbed solution reduces and simplifies the system into a second-order ODE and obtains a particular solution. It is observe that the commensurability occur between the frequencies: (i) ˙ γ and ˙ θm0, (ii) ˙ θm0 and ˙ α0 with the coefficient of resistive force. Finally, we analyze the dynamical behavior of the resonant curves for the orbital elements and the coefficient of resistive force.
Early childhood exposure to environmental phenols and parabens, phthalates, organophosphate pesticides, and trace elements in association with attention deficit hyperactivity disorder (ADHD) symptoms in the CHARGE study
Authors: Oh Jiwon , Kim Kyoungmi , Kannan Kurunthachalam , Parsons Patrick J. , Mlodnicka Agnieszka , Schmidt Rebecca J. , Schweitzer Julie B. , Hertz-Picciotto Irva , Bennett Deborah H. 
Published: February 2023

Abstract
Background
A growing body of literature investigated childhood exposure to environmental chemicals in association with attention deficit hyperactivity disorder (ADHD) symptoms, but limited studies considered urinary mixtures of multiple chemical classes. This study examined associations of concurrent exposure to non-persistent chemicals with ADHD symptoms in children diagnosed with autism spectrum disorder (ASD), developmental delay, and typical development.
Methods
A total of 574 children aged 2–5 years from the Childhood Autism Risks from Genetics and Environment (CHARGE) case-control study was administered the Aberrant Behavior Checklist (ABC). This study focused on the Hyperactivity subscale and its two subdomains (hyperactivity/impulsivity, inattention). Sixty-two chemicals from four classes (phenols/parabens, phthalates, organophosphate pesticides, trace elements) were quantified in child urine samples, and 43 chemicals detected in > 70% samples were used in statistical analyses. Weighted quantile sum regression for negative binomial outcomes with repeated holdout validation was performed to investigate covariate-adjusted associations between mixtures and ABC scores in 574 children. The mixture analyses were further restricted to 232 children with ASD.
Results
Phthalate metabolite mixtures, weighted for mono-n-butylphthalate (MNBP), mono-2-heptyl phthalate, and mono-carboxy isononyl phthalate, were associated with the Hyperactivity subscale (mean incidence rate ratio [mIRR] = 1.11; 2.5th, 97.5th percentile: 1.00, 1.23), especially the hyperactivity/impulsivity subdomain (mIRR = 1.14; 2.5th, 97.5th percentile: 1.06, 1.26). These associations remained similar after restricting to children with ASD. The inattention subdomain was associated with a phenols/parabens mixture, weighted for several parabens and bisphenols (mIRR = 1.13; 2.5th, 97.5th percentile: 1.00, 1.28) and a total mixture, weighted for 3,4-dihydroxy benzoic acid, MNBP, and mono-(2-ethyl-5-carboxypentyl) phthalate (mIRR = 1.11; 2.5th, 97.5th percentile: 1.01, 1.25) only among children with ASD.
Conclusions
Concurrent exposure to phthalate mixtures was associated with hyperactivity in early childhood. Though causal inference cannot be made based on our cross-sectional findings, this study warrants further research on mixtures of larger number of chemicals from multiple classes in association with ADHD-related behaviors in young children.
HOXB13 induced LncRNA CYTOR aggravates spinal cord injury induced neuropathic pain via upregulating TJP1
Authors: Huang Junming , Bi Yannan , Liu Xiaoming , Liu Fatai , Zhu Haodong , Zhong Weibin 
Published: February 2023

Abstract
Neuropathic pain (NP) is characterized as a pain disorder results from a lesion or disease of the nervous system. Due to the NP is related to multiple disease development including Shingles, stroke, cancer, trauma, and orthopedics, the prevalence of NP has reach to 10% all over the world. However, the underlying molecular mechanisms of NP progression remains unclear. Studies have reported that lncRNA is closely related to NP progression. In this study, we aimed to identify a novel functional lncRNA in NP. Firstly, our study successfully constructed chronic constructive injury (CCI) rat models for NP study. By performing lncRNA microarray analysis, we found that lncRNA CYTOR was markedly upregulated in the CCI rats. Subsequently, we performed a serial experiment to understanding the function of CYTOR in NP. Biologically, our results suggest that CYTOR aggravates NP progression and influences inflammation factors level in nerve tissues of CCI rats. Mechanically, our data indicate that CYTOR, transcriptionally regulated by HOXB13, upregulates TJP1 expression through sponging miR-105-5p. Our study identified a novel functional lncRNA CYTOR in NP progression, which might provide new insights for developing more effective diagnosis or therapeutic strategies for NP.
MC-PRPA-HLFIA cascade detection system for point-of-care testing pan-drug resistant genes in urinary tract infection samples
Authors: Tao Jin , Liu Dejun , Xiong Jincheng , Shan Wenchong , Dou Leina , Zhai Weishuai , Zhang Ying , Zhang Rong , Wang Yang , Shen Jianzhong , Wen Kai 
Published: February 2023

Abstract
Background
Recently, urinary tract infection (UTI) triggered by bacteria carrying the pan-drug resistant genes, including carbapenem resistance gene blaNDM and blaKPC, colistin resistance gene mcr-1, and tet(X) for tigecycline resistance have been reported, posing a serious challenge to the treatment of clinical UTI. Therefore, point-of care (POC) detection of these genes in UTI samples without the need for pre-culturing is urgently needed. We intend to develop a rapid on-site assay, which is capable of direct detection of pan-drug resistant genes in clinical UTI samples.
Methods
Based on PEG 200-enhanced recombinase polymerase amplification (RPA) and a refined Chelex-100 lysis method with HRP-catalyzed lateral flow immunoassay (LFIA), we developed an MCL-PRPA-HLFIA cascade assay system for detecting these genes in UTI samples.
Results
The refined Chelex-100 lysis method extracts target DNA from UTI samples in 20 minutes without high-speed centrifugation or pre-incubating urine samples. Following optimization, the cascade detection system achieved a LOD of 102 CFU/mL with satisfactory specificity and could detect these genes in both simulated and actual UTI samples.
Conclusions
It takes less than an hour to complete the process without the use of high-speed centrifuges or other specialized equipment, such as PCR amplifiers. The MCL-PRPA-HLFIA cascade assay system provides new ideas for the construction of rapid detection methods for pan-drug resistant genes in clinical UTI samples and provides the necessary medication guidance for the UTI treatment.
Central Retinal Vein Occlusion Associated with Bartonella Henselae Infection
Authors: Bellur Sunil , Ali Amir , Nguyen Nam V. , Fernandes Joshua K. , Kodati Shilpa 
Published: February 2023

Abstract
Purpose:
To report the clinical features and treatment course of a case of central retinal vein occlusion (CRVO) as the initial sign of ocular Bartonella henselae (B. henselae) infection.
Observation:
A 36-year-old male was evaluated for unilateral vision loss. He denied prodromal symptoms but reported prior exposure to fleas. Best corrected visual acuity (BCVA) was 20/400 in the left eye. Clinical examination revealed a CRVO with atypical features including significant peripapillary exudates and peripheral vascular sheathing. Laboratory testing revealed elevated B. henselae IgG titers (1:512) with no abnormalities on hypercoagulability testing. The patient was treated with doxycycline and aflibercept with an excellent clinical response and improvement in BCVA to 20/25 in the left eye two months later.
Conclusion:
CRVO is a rare but sight-threatening complication of ocular bartonellosis and can be the presenting sign of infection, even in the absence of cat exposure or prodromal symptoms.
Growth of the Wang-Casati-Prosen counter in an integrable billiard
Authors: Hwang Zaijong , Marx Christoph A. , Seaward Joseph J. , Jitomirskaya Svetlana , Olshanii Maxim 
Published: February 2023

This work is motivated by an article by Wang, Casati, and Prosen
[Phys. Rev. E vol. 89, 042918 (2014)] devoted to a study of ergodicity
in two-dimensional irrational right-triangular billiards. Numerical
results presented there suggest that these billiards are generally not
ergodic. However, they become ergodic when the billiard angle is equal
to \pi/2π/2
times a Liouvillian irrational, morally a class of irrational numbers
which are well approximated by rationals. In particular, Wang et
al. study a special integer counter that reflects the irrational
contribution to the velocity orientation; they conjecture that this
counter is localized in the generic case, but grows in the Liouvillian
case. We propose a generalization of the Wang-Casati-Prosen counter:
this generalization allows to include rational billiards into
consideration. We show that in the case of a
45°\!\!:\!45°\!\!:\!90°45°:45°:90°
billiard, the counter grows indefinitely, consistent with the
Liouvillian scenario suggested by Wang et al.
Community awareness of dental fluorosis as a health risk associated with fluoride in improved groundwater sources in Mangochi District, Malawi
Authors: Andreah Kondwani , Tembo Mavuto , Manda Mtafu 
Published: February 2023

AbstractFluoride is one of the priority chemicals being monitored under the sustainable development goal target for drinking water. Excessive ingestion of fluoride in concentrations higher than 1.5 mg/L may cause dental, skeletal and neurological disorders. The study assessed community awareness of dental fluorosis as a health risk associated with fluoride contamination in groundwater sources in Mangochi district. Water samples from 82 water points were tested for fluoride and concentrations between 0.2 and 27.2 mg/L were detected, with a mean value of 3.7 mg/L and a median value of 3.1 mg/L. Nine water points registered fluoride concentrations above 6 mg/L, which is Malawi standard value for fluoride in boreholes and shallow wells. Prevalence rate for dental fluorosis among children in the study was at 82.7%. However, 100% of the children's parents displayed low or no awareness of dental fluorosis as a health risk associated with fluoride contamination in drinking water. The study recommends the use of solar powered reticulated systems, whose water source shall be from a contamination-free zone, and supply to the affected villages. Human health risk assessment using the US-EPA approach needs to be conducted in the affected villages to understand the extent of exposure to fluoride-related health risks.
Optimization and modeling of Tramadol hydrochloride degradation by the homogenous photo-Fenton-like system assisted by in situ H2O2 formation
Authors: Haciane Yamina Meziane , Bouafia Souad Chergui , Chabani Malika , Imene Kahina Benramdane , Mebtouche Manel , Neffa Mounsef , Touzani Rachid 
Published: February 2023

ABSTRACT

This study examines the removal efficiency of Tramadol hydrochloride (TR) and mineralization (chemical oxygen demand, COD) by the effective photoinduced Fenton-simulated system under artificial light (UVA). The Box-Behnken design was used to optimize the value of each parameter. The model yielded the following optimal parameters: [TR]0 = 10 mg, ratio ([Oxalate ]0/[Fe3+]0) = 100, initial pH = 2.83, and [Fe3 +]0 = 1.298 mg with effective TR removal (100%) and COD removal efficiency (72.82%). The presence of oxygen has a positive effect by increasing hydrogen peroxide production from 4.36 to 8.12 mg L−1 and by maximizing a change in Fe3+ speciation. The degradation kinetics of ΤR in the oxygen-saturated medium is four times faster than that in the normal aerated medium. The Kapp rate constants increased quickly from 5.72 × 10−2 to 20 × 10−2min−1. The percent COD removal increased to 87.46%, and the final pH increased from 5.31 to 6.23.
(RE)PENSANDO O CURRÍCULO ESCOLAR: A IMPORTÂNCIA DA LEITURA LITERATURA AFRO-BRASILEIRA NO ENSINO-APRENDIZAGEM EM SALA DE AULA
Authors: Nogueira Nedson Antônio Melo 
Published: February 2023

O presente trabalho tem como finalidade refletir sobre a importância da literatura afro-brasileira em sala de aula, tendo como base a lei federal sancionada 10.639/03, que torna obrigatório (como cumprimento de lei) as histórias e as culturas africanas e afro-brasileiras, assim como as histórias e as culturas indígenas (lei 11.645/08) nas instituições de ensino, sendo elas públicas ou privadas, aqui só enfatizaremos à primeira lei. Ancorados a uma perspectiva de leitura literária vinculada às práticas cotidianas e ao conhecimento de mundo trazido pelos/as alunos/as segundo os PCNs (1998), procuraremos problematizar as condições (e a falta delas) de se abordar uma prática de leitura constituinte e constitutiva para a formação crítica e participativa dos/as alunos/as como também possibilitar, além de resgatar, os saberes e os valores históricos e culturais construídos pelos povos africanos ao longo das gerações. Adotando pressupostos de teóricos/as que pensam a prática leitora no contexto escolar, entre eles (FREIRE, 1989; SILVA, 2003; DALVI, 2010), vemos o quanto é necessária a sua inserção no ensino-aprendizagem em aulas de língua portuguesa, em especial, nas de Literatura. Para finalizar, trazemos à baila as principais nuances que inviabilizam a falta de formação/qualificação dos/as educadores/as em desenvolverem atividades pedagógicas que sejam pertinentes a prática leitora assim como as temáticas africanas e afro-brasileiras a uma formação de pertença e autoafirmação afro-descendente; o descaso do currículo escolar no tocante as africanidades diante do que prioriza à lei supramencionada, e o que defende os documentos oficiais e suas diretrizes para o fortalecimento de uma educação antirracista e mais pluricultural.

Palavras-Chave: Africanidades. Afro-descendência. Lei 10.639/03. Prática leitora.
Institucionalização da sustentabilidade organizacional
Authors: Lopes Sócrates Dantas , Diniz Morais Ione Rodrigues 
Published: February 2023

As discussões acerca do tema sustentabilidade foram ampliadas em meio à crise socioambiental, que se revela por meio da elevada degradação ambiental, do aumento da pobreza e da desigualdade social. Nesse contexto, a noção de sustentabilidade adquire proeminência, passando a ser institucionalizada por empresas que atuam em diferentes escalas geográficas, enfatizando a importância da Sustentabilidade Organizacional enquanto conceito que norteia princípios éticos que reordenam as práticas operacionais das empresas rumo à promoção do desenvolvimento sustentável. O objetivo deste trabalho é analisar a institucionalização da sustentabilidade organizacional pelas facções têxteis do Seridó. Para sua realização utilizou-se pesquisa bibliográfica, documental e de campo, ressaltando-se a aplicação do Método para Avaliação de Indicadores de Sustentabilidade Organizacional (M.A.I.S). Os procedimentos seguiram a sistemática da Triangulação de Dados: entrevistas, levantamento documental nas empresas faccionistas e observação in loco. Considerando os resultados da pesquisa quanto ao nível de sustentabilidade organizacional, a pontuação obtida pelo conjunto da amostra indica que as empresas faccionistas têxteis se na faixa Sustentável.
Palavras-chave: Sustentabilidade organizacional. Indicadores de sustentabilidade. Facções têxteis.
Numerical method and mathematical model for finding the equilibrium composition of the thermodynamic system of the T-Energy software package
Authors: Sechenov P. A. , Rybenko I. A. 
Published: February 2023

Objective. The aim of the study is to develop a mathematical model and numerical methods for finding the equilibrium composition of a thermodynamic system.Method. To find the equilibrium composition of the thermodynamic system, a combination of numerical methods was used: Lagrange, Newton–Raphson and Gauss.Result. The analysis of existing software systems and numerical methods used in them for the calculation of thermodynamic systems is carried out. Based on the analysis, practical implementation attempts, it was possible to develop a mathematical model consisting of numerical Lagrange methods (allows you to move from a conditional problem to an unconditional one); Newton–Raphson (an approximate method for solving a nonlinear system of equations); Gauss (solving a linear system of equations). For the convergence of the Newton–Raphson method, the required quantities were replaced by their squares, and ranges of variation were set for each quantity. The results of comparing the calculations of the equilibrium composition with the Terra program show satisfactory results.Conclusion. The T-Energy software package allows you to calculate the equilibrium composition for a thermodynamic system.
Stegan detection method for latent images for intellectual property protection systems
Authors: Tebueva F. B. , Ogur M. G. , Mandritsa I. V. , Chernyshev A. B. , Linets G. I. , Mochalov V. P. 
Published: February 2023

Objective.Improving the quality of detection and stego-detection of latent images embedded in the protected object of intellectual property by various methods.Method.The method for stego-detection of latent images based on deep learning is proposed. The method is based on the use of the VGG16 convolutional neural network model, in which the architecture and training parameters are optimized.Result.Increasing the accuracy of detecting stegocontainer images by 3.8%, as well as the possibility of using the algorithm of the developed method for images with a higher resolution than the dimension of the input of an artificial neural network.Conclusion.The developed method is intended for stegan detection in two cases: to detect the fact of illegal use of intellectual property objects; for use in computer forensics when identifying images containing hidden and prohibited information.
Features of Accounting for Geometric and Physical Nonlinearities in Long-Span Pneumatic Membrane Systems
Authors: Kim A. Yu. , Polnikov S. V. , Amoyan M. F. 
Published: February 2023

Objective. The purpose of the study is to substantiate the need to take into account the geometric and physical nonlinearities in large-span membrane-pneumatic systems.Method. The study is based on the application of the parameter variation method; method of successive loadings; the iterative method of parameter increments using the third Euler-Cauchy numerical procedure or the Runge-Kutta method of a higher order of accuracy.Result. It has been established that the geometric non-linearity can be from 5 to 10% if the structure has a small or medium span, and the load on the structure is not very large, especially when it comes to section load. If the span of the structure is 120150 meters, and the load and deflections are large enough, then the geometric nonlinearity can be 20% or more. It was revealed that the physical nonlinearity, which we took into account by the standard Euler-Cauchy procedure of the third order of accuracy, with a large span of the structure and a large load is approximately 13-21%, and the part of the physical nonlinearity of the air pumped between the hermetic membranes of the structure is determined using an improved formula Euler-Cauchy with the number of iterations 20-25, i.e. "aftereffect", according to the results of the study, ranges from 2-7%.Conclusion. A structure consisting of light metal structures can be erected within a few months on a finished pile or strip foundation. Such structures can easily withstand many types of dynamic loads, namely wind, seismic, vibration, and are one-third cheaper than buildings made from traditional materials.
Mathematical modeling of evaporation processes in a heat pump circuit
Authors: Fedoseev V. N. , Loginova S. A. 
Published: February 2023

Objective. In order to improve the control system of an air heat pump and increase its efficiency, it is necessary to take into account as accurately as possible all the elementary stages of the processes occurring in the system under consideration. The article discusses in detail the heat and mass transfer process of evaporation of the refrigerant from the boiling working fluid of a heat pump.Method. Description of heat and mass transfer processes occurring in the evaporator line of an air heat pump.Result. A numerical experiment was carried out to determine the size of the refrigerant droplets that can fly out of the boiling freon liquid during the operation of the heat pump. The calculations performed showed that droplets with a diameter of less than 1 mm have time to evaporate in the vapor flow during the movement from the boiling zone to the droplet eliminator located in front of the compressor.Conclusion. Research will make it possible to develop recommendations for the design of the droplet collection unit, as well as to develop models for optimizing the operating modes of air source heat pumps.