bluuebunny/crossref_metadata_2025_split huggingface dataset:
The digital journey: 25 years of digital development in electrophysiology from an Europace perspective
Authors: Svennberg Emma , Caiani Enrico G , Bruining Nico , Desteghe Lien , Han Janet K , Narayan Sanjiv M , Rademakers Frank E , Sanders Prashanthan , Duncker David 
Published: August 2023

Abstract

Aims
Over the past 25 years there has been a substantial development in the field of digital electrophysiology (EP) and in parallel a substantial increase in publications on digital cardiology.
In this celebratory paper, we provide an overview of the digital field by highlighting publications from the field focusing on the EP Europace journal.

Results
In this journey across the past quarter of a century we follow the development of digital tools commonly used in the clinic spanning from the initiation of digital clinics through the early days of telemonitoring, to wearables, mobile applications, and the use of fully virtual clinics. We then provide a chronicle of the field of artificial intelligence, a regulatory perspective, and at the end of our journey provide a future outlook for digital EP.

Conclusion
Over the past 25 years Europace has published a substantial number of papers on digital EP, with a marked expansion in digital publications in recent years.
Risk stratification of sudden cardiac death: a review
Authors: Tfelt-Hansen Jacob , Garcia Rodrigue , Albert Christine , Merino Jose , Krahn Andrew , Marijon Eloi , Basso Cristina , Wilde Arthur A M , Haugaa Kristina Hermann 
Published: August 2023

Abstract
Sudden cardiac death (SCD) is responsible for several millions of deaths every year and remains a major health problem. To reduce this burden, diagnosing and identification of high-risk individuals and disease-specific risk stratification are essential. Treatment strategies include treatment of the underlying disease with lifestyle advice and drugs and decisions to implant a primary prevention implantable cardioverter-defibrillator (ICD) and perform ablation of the ventricles and novel treatment modalities such as left cardiac sympathetic denervation in rare specific primary electric diseases such as long QT syndrome and catecholaminergic polymorphic ventricular tachycardia. This review summarizes the current knowledge on SCD risk according to underlying heart disease and discusses the future of SCD prevention.
Evidence for stronger sexual selection in males than in females using an adapted method of Bateman’s classic study of Drosophila melanogaster
Authors: Davies Natasha , Janicke Tim , Morrow Edward H 
Published: August 2023

Abstract
Bateman’s principles, originally a test of Darwin’s theoretical ideas, have since become fundamental to sexual selection theory and vital to contextualizing the role of anisogamy in sex differences of precopulatory sexual selection. Despite this, Bateman’s principles have received substantial criticism, and researchers have highlighted both statistical and methodological errors, suggesting that Bateman’s original experiment contains too much sampling bias for there to be any evidence of sexual selection. This study uses Bateman’s original method as a template, accounting for two fundamental flaws in his original experiments, (a) viability effects and (b) a lack of mating behavior observation. Experimental populations of Drosophila melanogaster consisted of wild-type focal individuals and nonfocal individuals established by backcrossing the brown eye (bw-) eye-color marker—thereby avoiding viability effects. Mating assays included direct observation of mating behavior and total number of offspring, to obtain measures of mating success, reproductive success, and standardized variance measures based on Bateman’s principles. The results provide observational support for Bateman’s principles, particularly that (a) males had significantly more variation in number of mates compared with females and (b) males had significantly more individual variation in total number of offspring. We also find a significantly steeper Bateman gradient for males compared to females, suggesting that sexual selection is operating more intensely in males. However, female remating was limited, providing the opportunity for future study to further explore female reproductive success in correlation with higher levels of remating.
Convergent Evolution in a Murine Intestinal Parasite Rapidly Created the TGM Family of Molecular Mimics to Suppress the Host Immune Response
Authors: Maizels Rick M , Newfeld Stuart J 
Published: August 2023

Abstract
The Transforming Growth Factor-β mimic (TGM) multigene family was recently discovered in the murine intestinal parasite Heligmosomoides polygyrus. This family was shaped by an atypical set of organismal and molecular evolutionary mechanisms along its path through the adaptive landscape. The relevant mechanisms are mimicry, convergence, exon modularity, new gene origination, and gene family neofunctionalization. We begin this review with a description of the TGM family and then address two evolutionary questions: “Why were TGM proteins needed for parasite survival” and “when did the TGM family originate”? For the former, we provide a likely answer, and for the latter, we identify multiple TGM building blocks in the ruminant intestinal parasite Haemonchus contortus. We close by identifying avenues for future investigation: new biochemical data to assign functions to more family members as well as new sequenced genomes in the Trichostrongyloidea superfamily and the Heligmosomoides genus to clarify TGM origins and expansion. Continued study of TGM proteins will generate increased knowledge of Transforming Growth Factor-β signaling, host–parasite interactions, and metazoan evolutionary mechanisms.
‘We know what he likes, even if he doesn’t know’: how the children of South Asian immigrants characterize and influence the diets of their parents
Authors: Auer Sian , Penikalapati Rushitha , Parekh Niyati , Merdjanoff Alexis A , DiClemente Ralph J , Ali Shahmir H 
Published: August 2023

Abstract
Foreign-born (first-generation) South Asians face a growing diet-related chronic disease burden. Little is known about whether the adult US-born (second-generation) children of South Asian immigrants can provide unique insights as changemakers in their parents’ dietary behaviors. This study aims to assess how second-generation South Asians describe and influence the dietary behaviors of their parents. Between October and November 2020, 32 second-generation South Asians [mean age 22.4 (SD 2.9), 53% female] participated in online interviews centered around factors involved in their (and their parents) eating behaviors. Thematic analysis revealed three types of parental dietary drivers (socioecological factors that impact the dietary choices of parents): goal-oriented (i.e., parents’ dietary intentionality), capacity-related (e.g., environmental barriers) and sociocultural (cultural familiarity, religion and traditions). Participants described three major mechanisms of influence: recommending new foods, cooking for parents, and bringing new foods home. These influences primarily occurred in the household and often involved participants leveraging their own nutritional knowledge and preferences to expand dietary diversity and healthier behaviors among their parents. Evidence suggests that second-generation South Asians may act as powerful agents of dietary change within their households and can provide novel insights to help address and overcome sociocultural, linguistic, and other structural barriers to better understanding and intervening in the health of the South Asian community.
Nationwide Real-World Exclusive Enteral Nutrition Practice Over Time: Persistence of Use as Induction for Pediatric Crohn’s Disease and Emerging Combination Strategy With Biologics
Authors: Wands David I F , Gianolio Laura , Wilson David C , Hansen Richard , Chalmers Iain , Henderson Paul , Gerasimidis Konstantinos , Russell Richard K 
Published: August 2023

Abstract

Background
Exclusive enteral nutrition (EEN) is the recommended first-line induction treatment in pediatric patients with active luminal Crohn’s disease (CD). We aimed to provide a nationwide overview of evolving EEN practices during an era of increasing biologic use.

Methods
We analyzed a prospectively identified nationwide cohort of newly diagnosed pediatric patients with CD in Scotland between January 1, 2015, and June 30, 2022. Patients who received EEN for any indication were divided into 6-monthly epochs and examined over time. Differences during the COVID-19 pandemic (March 16, 2020, to July 19, 2021) were examined. Data were retrospectively collected from electronic medical records: demographics, anthropometrics, concomitant treatments, aspects of EEN administration, and remission/response rates. Descriptive statistics and linear regression were used for analyses.

Results
A total of 649 patients with CD were identified (63% male; median age 12.6 [interquartile range, 10.8-14.8] years); 497 (77%) of 649 received EEN as postdiagnosis induction therapy with a median course length of 7.7 (interquartile range, 5.9-8.0) weeks. Including repeat courses, 547 EEN courses were examined. An increasing incidence of CD was observed over time with no significant changes in EEN usage, remission or response rates, nasogastric tube usage, or course completion (all P &gt; .05). Increasing use of EEN combined with biologics (combination induction) as first-line induction was observed over time (P &lt; .001). Considering COVID-19, lower rates of EEN usage were observed (P = .008) with no differences in remission, oral administration, and course completion rates (all P &gt; .05).

Conclusions
Over the past 7.5 years, except during the COVID-19 pandemic, EEN usage rates have not changed despite an increase in biologic use, although combination induction is an emerging trend.
Efficacy of Ustekinumab Optimization by 2 Initial Intravenous Doses in Adult Patients With Severe Crohn’s Disease
Authors: Ren Haixia , Kang Jian , Wang Jing , Su Juan , Zou Liping , Yin Anning , Li Jiao , Zhou Qian , Wang Wei , Tang Zhishun , Zhang Jing , Lu Yueyue , Yang Yuanping , Qiu Chengen , Ding Yijuan , Dong Weiguo , An Ping 
Published: August 2023

Abstract

Background
Although increasing studies have reported that dose escalation can improve treatment response to ustekinumab in patients with Crohn’s disease (CD), their strategies mainly focus on maintenance regimen. Evidence of ustekinumab dose escalation in induction regimen, particularly in severe CD, remains limited. This study evaluated the efficacy and safety of intravenous ustekinumab with 2 initial doses in patients with severely active CD.

Methods
A retrospective observational study of 99 adult patients with severe CD treated with ustekinumab from 3 IBD centers included 48 patients with standard and 51 with optimized induction treatment. Clinical outcomes, inflammatory biomarkers including fecal calprotectin (FC) normalization, and endoscopic outcomes were evaluated at weeks 16 and 48. Adverse events and treatment decisions after initial induction were also collected.

Results
Compared with the standard group, 2 initial intravenous injections of ustekinumab achieved higher clinical response (92.2%, 47 of 51, P = .656), clinical remission (88.2%, 45 of 51, P = .221), endoscopic response (75.8%, 25 of 33, P = .125), and FC normalization (70.6%, 36 of 51, P = .138) at week 16. The mucosal healing rate at week 16 (63.6%, P = .022) was statistically higher in the optimization group. At week 48, patients with optimized treatment achieved higher clinical response (80.4%, 41 of 51, P = .003), clinical remission (70.6%, 36 of 51, P = .007), FC normalization (66.7%, 34 of 51, P = .031), endoscopic response (72.7%, 24 of 33, P = .006), and mucosal healing (57.6%, 19 of 33, P = .004). At the last follow-up, 82.4% of optimally treated patients adhered to continued treatment with ustekinumab (P &lt; .001).

Conclusions
Optimization of ustekinumab by 2 initial intravenous inductions is more effective than standard therapy for adult patients with severe CD.
Assessment of Humoral Immune Responses to Repeated Influenza Vaccination in a Multiyear Cohort: A 5-Year Follow-up
Authors: Sung Meng-Hsuan , Billings W Zane , Carlock Michael A , Hanley Hannah B , Bahl Justin , Handel Andreas , Ross Ted M , Shen Ye 
Published: August 2023

Abstract
The long-term effects of host factors on vaccine-elicited immune responses have not been well studied, and the interactions of host factors with annual influenza vaccinations are yet to be explored. We analyzed data from a cohort of 386 individuals who received the standard-dose influenza vaccine and enrolled in ≥2 seasons from 2016 to 2020. Our analyses indicated disparate vaccine-elicited immune responses between males and females in adults when they were repeatedly vaccinated for at least 2 seasons. Notably, we found interactive effects between age and body mass index (BMI) on overall immune responses, and between sex at birth and BMI in adults.
Effect of the supplementation with a combination of plant extracts on sow and piglet performance and physiology during lactation and around weaning
Authors: Herve Lucile , Quesnel Hélène , Greuter Amaury , Hugonin Laurent , Merlot Elodie , Le Floc’h Nathalie 
Published: August 2023

Abstract
Weaning is a critical period for pigs. Some plant extracts showing antioxidant, anti-inflammatory or antibacterial properties, provided to piglets and/or their dam, may improve piglets’ robustness at weaning, thus reducing the need for antobiotics. This study investigated the effects of a maternal and/or a direct supplementation of piglets with a combination of plant extracts on sow and piglet performance and their metabolic, immune, inflammatory, and oxidative status during lactation and around weaning. Sixty-four sows were assigned to the control or treated group. Treated sows were supplemented with a powdered plant extracts supplement daily top-dressed on feed from day of gestation (DG) 106 to day of lactation (DL) 28 and a liquid solution top-dressed on feed on DG109. Within each sow group, litters were divided into two groups: a control piglet group and a treated piglet group. A single dose of a liquid solution was orally given to piglets in the treated piglet group. Piglets were weaned on DL28. Blood samples were collected from sows on DG94, DG112, and DL26 and from 2 piglets per litter on DL3, DL14, DL25, and 5 d postweaning to analyze indicators of metabolic, immune, inflammatory, and oxidative status. Colostrum and milk samples were collected at farrowing, DL6, and 26. Maternal supplementation had no effect on sow metabolic, immune, inflammatory, and oxidative status except for fewer lymphocytes on DG112 (P &lt; 0.05) and a lower plasma concentration of non-esterified fatty acids on DL26 (P &lt; 0.05). Maternal supplementation tended to decrease dry matter and gross energy (P &lt; 0.10) and reduced fat and haptoglobin concentrations (P &lt; 0.01) in milk on DL26. Maternal supplementation had no effect on piglets’ growth performance and blood indicators during lactation and around weaning. On DL25, the direct supplementation of piglets decreased their neutrophils proportion (P &lt; 0.05), increased the expression of genes encoding pro- and anti-inflammatory cytokines in whole blood culture in response to lipopolysaccharide (P &lt; 0.05) and tended to decrease the oxidative stress index (P = 0.06). After weaning, these beneficial effects were no longer observed but the supplementation improved piglets’ growth performance during the postweaning period (P &lt; 0.05). Plant extract supplementation could thus modify the composition of mammary secretions and improve postweaning performance of piglets potentially related to the modification of their immune and oxidative status before weaning.
A Qualitative Analysis on the Experiences of Mothers of Children in Burn Intensive Care Unit: “She burned on the outside, me inside...”
Authors: Karahan Sabri , Ay Kaatsiz Melike Ayça , Erbas Atiye , Kaya Yunus 
Published: August 2023

Abstract
Mothers closely follow the complex process due to the burning of their children. Caring for and supporting the child can pose various challenges for mothers. With the phenomenological method, this study was conducted to investigate mothers’ experiences staying with their children in the pediatric burn intensive care unit. Twelve mothers participated in the study. The semistructured face-to-face interviews obtained data. After each interview, the research team transcribed the interviews verbatim. Interpretive Phenomenological Analysis was used to analyze the data. The experiences of the mothers were classified in four contexts as a result of the interpretative phenomenological analysis; “first reactions to burn trauma” related to the awareness that the child has been burned, “being a mother in the burn intensive care unit” related to caring for the child as a companion in the burn intensive care unit, “coping” related to how they cope with the problems throughout the whole process, and “requirements” regarding the subjects it needs in the process. It was determined that mothers went through a physically and emotionally challenging process from the beginning of the burn trauma and throughout the intensive care unit. During this challenging process, it was observed that mothers could not use effective coping methods and did not receive the necessary professional support. In line with these results, it is recommended that psychological support programs be applied to the mothers and that care focused on the needs of the mothers should be provided.
Eileen Gray and Jean Badovici at Vézelay
Authors: Benton Tim 
Published: August 2023

Abstract
The study of collaborative work by architects and designers can present difficulties. The principal biographers of Eileen Gray asserted that she played the key role in the design of the houses that her friend Jean Badovici (1893–1956) acquired and transformed in Vézelay between 1926 and 1934 and that this work contributed to the design of her other buildings. This claim is worth investigating because the Vézelay houses present innovative and distinctive features, and because Jean Badovici’s qualities as architect have been insufficiently studied. A method is presented here for distinguishing between different hands based on the forensic analysis of individual words and letters. This approach could be of use in many contexts but particularly in the case of close collaboration between architects and designers. Applied initially to drawings for Badovici’s houses at Vézelay, the method can be applied to the many other drawings in the archives of the V&A, the Pompidou Centre, the Eileen Gray archive in the National Museum of Ireland, and the Badovici archive in the Getty Research Institute. The evidence from this analysis is set alongside other arguments for evaluating Gray’s involvement in the design of the Badovici houses at Vézelay. The aim of this essay is not to challenge Gray’s collaboration in the design process but to test claims of her sole or principal role in the design of these houses.
The global relevance of Tagore’s cosmopolitan educational philosophy for social justice in a post-Westphalian world
Authors: Banga Sunil 
Published: August 2023

ABSTRACT
This article suggests that Tagore’s conception of cosmopolitan education can provide the basis for advancing matters of global social justice, when considering the problem posed by Nancy Fraser in her essay ‘Reframing Justice in a Globalizing World’: ‘How can we integrate struggles against maldistribution, misrecognition and misrepresentation within a post-Westphalian frame?’. To this end, the article briefly reflects on the perspective of cosmopolitanism, setting the scene for an exploration of Tagore’s distinctive cosmopolitan educational philosophy. The article develops the argument that framing pedagogy centred on Tagore’s principles of cosmopolitan education to produce cosmopolitan-minded citizens can help bring about social, political, and economic change at local, national, and international level, in order to integrate the three-dimensional struggle for social justice outlined by Fraser. The article concludes by suggesting what can be done at the institutional and curriculum levels to help foster the cosmopolitan attitude.
NtMYB1 and NtNCED1/2 control abscisic acid biosynthesis and tepal senescence in Chinese narcissus (Narcissus tazetta)
Authors: Yang Jingwen , Huang Jiazhi , Wu Xi , Xu Yun , Gu Zheng , Chen Yajue , Zhang Yu , Ren Yujun , Miao Ying 
Published: August 2023

Abstract
Chinese narcissus (Narcissus tazetta var. chinensis cv. ‘Jinzhanyintai’) is one of the 10 most famous traditional flowers of China, having a beautiful and highly ornamental flower with a rich fragrance. However, the flower longevity affects its commercial appeal. While petal senescence in Narcissus is ethylene-independent and abscisic acid-dependent, the regulatory mechanism has yet to be determined. In this study, we identified a R2R3-MYB gene (NtMYB1) from Narcissus tazetta and generated oeNtMYB1 and Ntmyb1 RNA interference mutants in Narcissus as well as an oeNtMYB1 construct in Arabidopsis. Overexpressing NtMYB1 in Narcissus or Arabidopsis led to premature leaf yellowing, an elevated level of total carotenoid, a reduced level of chlorophyll b, and a decrease in photosystem II fluorescence (Fv/Fm). A dual-luciferase assay and chromatin immunoprecipitation–quantitative PCR revealed that NtMYB1 directly binds to the promoter of NtNCED1 or NtNCED2 and activates NtNCED1/2 gene expression both in vitro and in vivo. Moreover, overexpressing NtMYB1 accelerated abscisic acid biosynthesis, up-regulated the content of zeatin and abscisic acid, and down-regulated the level of β-carotene and gibberellin A1, leading to petal senescence and leaf yellowing in Narcissus. This study revealed a regulatory process that is fundamentally different between non-photosynthetic organs and leaves.
Patient Satisfaction in Military Dental Clinics—Findings From the Department of Defense Dental Patient Satisfaction Survey
Authors: Buss Kathleen D , Schindler David K , Matis Steven A , Lopez Mitnik Gabriela V , Boroumand Shahdokht , Dye Bruce A 
Published: August 2023

ABSTRACT

Introduction
An objective of the Military Health System is to deliver an improved health care experience. Patient satisfaction affects the patient experience, health outcomes, and treatment compliance. The purpose of this study is to identify indicators of high and low patient satisfaction within a military dental setting.

Materials and Methods
De-identified data from 248,342 responses to the DoD Dental Patient Satisfaction Survey conducted from October 2014 to March 2016 were used. The overall satisfaction and other related outcomes were analyzed by age, sex, beneficiary status, current rank, current Service, type of dental treatment, clinic location, and clinic size. Unpaired t-tests and logistic regression modeling were used to ascertain relationships between various aspects of patient satisfaction and variables of interest.

Results
Overall, 96% of patients attending military dental clinics were satisfied, whereas 72% of patients were satisfied with the number of days waited for an appointment. Air Force patients were the most satisfied compared to their Army, Navy, and Marine Corps counterparts. Patients treated in small dental clinics (less than 5 dentists) were 74% more satisfied than patients treated at large dental clinics (more than 12 dentists). Patients seeking routine dental treatment were significantly more satisfied with the number of days waiting for an appointment (odds ratio = 8.03; 95% CI: 7.64–8.43) compared to patients waiting for an emergency dental appointment.

Conclusions
There were important differences in patient satisfaction by military Service and clinic size, suggesting that improvement in satisfaction may need to be Service specific. These differences warrant further research that could inform policy changes directed at improving service members’ dental care and readiness.