bluuebunny/crossref_metadata_2025_split huggingface dataset:
The psychosocial burdens of living with diabetes
Authors: Kelly Ryan Charles , Holt Richard I. G. , Desborough Lane , Majidi Shideh , Town Marissa , Naranjo Diana , Messer Laurel , Barnard Ethan , Soderberg Jeannette , Barnard‐Kelly Katharine 
Published: September 2023

AbstractAimTo better understand the prevalence of self‐reported psychosocial burdens and the unmet needs identified by people with diabetes in relation to routine diabetes visits.MethodsAn English language, online survey was distributed via social media, key stakeholder networks, charity and advocacy groups to adults with type 1 diabetes or type 2 diabetes. Survey items were designed by members of the FDA RESCUE Collaborative Community Governing Committee prior to pilot testing with potential participants. Descriptive statistical analyses were conducted, as well as thematic analyses on free‐text responses using NVivo v14.ResultsFour hundred and seventy‐eight participants completed the survey: 373 (78%) had type 1 diabetes, 346 (73%) identified as a woman and 433 (91%) were white. Most participants had experienced self‐reported (rather than diagnosed) anxiety and depression (n = 323 and n = 313, respectively), as well as fear of low blood sugars (n = 294), low mood (n = 290) and diabetes‐related distress (n = 257). Sixty‐eight percent reported that diabetes had negatively affected self‐esteem, 62% reported the feelings of loneliness, but 93% reported that friends/family/work colleagues were supportive when needed. Two hundred and seventy‐two percent (57%) reported that their diabetes team had never raised the topic of mental health. The overwhelming majority stated that the best thing their diabetes team could do to help was to simply ask about mental well‐being, listen with empathy and without judgement, and practice skills to understand psychosocial issues in diabetes.ConclusionIntegrating psychosocial discussions and support within routine healthcare visits is crucial to improve outcomes for people with diabetes. Such a biopsychosocial model of healthcare has long been advocated by regulatory bodies.
Bridged bicyclic compounds: Comprehending a novel compound class as potential anti‐seizure agents
Authors: Stilley Samantha E. , Naraine Akshay S. , Yadavalli Krishna P. , Maki Samantha L. , Jutte Elyse M. , Kahn Jared M. , Surtel Alexis A. , Lepore Salvatore D. , Dawson‐Scully Ken 
Published: September 2023

AbstractObjectiveIn the present study, we describe a novel class of small‐molecule synthetic compounds that ameliorate seizure‐like behavior, using an electroshock assay to examine seizure duration in Caenorhabditis elegans. We also examine the hypothesis that these compounds, which we have called resveramorphs (RVMs), act by an irreversible binding mechanism.MethodsOur electroshock assay examines seizure duration in C. elegans and can be used as a drug‐screening platform for the identification of novel anti‐seizure agents. The use of C. elegans allows for a rapid and efficient method of drug screening that may take years in other higher‐order model organisms. A novel wash method, paired with our electroshock assay, allows us to discern differences in biological activity when the C. elegans are incubated in different drug solutions, to establish whether these compounds can be “washed” off.ResultsOne of the RVMs (RVM‐3), reported here for the first time, was found to be potent at picomolar concentrations. Insights also provided information on the potential mechanisms of action of this compound. Covalent binding is thought to provide a strong irreversible bond because of a change in structure between two of the novel RVMs described in this work. This was also discerned through the novel wash method paired with our electroshock assay.SignificanceRVM‐3 was evaluated using our assay and found to possess anti‐seizure activity at picomolar concentrations. These insights also provide information on the potential mechanisms of action of these compounds, which may include covalent binding. This was also discerned through a novel wash method paired with our electroshock assay.
A comparison of Generation Z and Millennial dental hygiene students' preferred learning styles
Authors: Turner April M. , Gurenlian JoAnn R. 
Published: September 2023

AbstractObjectivesLearning styles have been studied in dental and generational research, but research has been limited with Millennial and Generation Z dental hygiene students. The purpose of this quantitative comparative study was to determine if and to what extent there was a difference between Generation Z and Millennial dental hygiene students' preferred learning styles.MethodsFirst‐ and second‐year dental hygiene students attending three programs located in Southern California were invited to participate in the study. Additional participants were recruited through dental hygiene social media sites. The 44 item Felder–Soloman Index of Learning Styles (ILS) was administered via an online survey platform. Millennial and Generation Z participants were compared on the four dimensions of the ILS: active/reflective, sensing/intuitive, visual/verbal, and sequential/global. The data were analysed using descriptive statistics and the independent samples t‐test.ResultsA total of 150 dental hygiene students agreed to participate; Millennials (n = 61), Generation Z (n = 89). There was no significant difference between Millennial and Generation Z students in the active/reflective, sensing/intuitive, or sequential/global dimensions (p > 0.05); both cohorts preferred the active, sensing, and sequential learning styles. There was a statistically significant difference in the visual/verbal dimension with Millennials indicating a significantly greater preference for the visual learning style than Generation Z (p = 0.04).ConclusionThere may be differences between the learning styles of Millennial and Generation Z dental hygiene students. The finding that Generation Z students differ significantly from Millennials on the visual–verbal dimension may indicate a shift toward the verbal dimension learning style that needs further study.
Immunoprophylactic and Serological Investigations in Cow Abortions caused by Bacteria of the Group Mimeae and Genus Yersinia
Authors: Gelev I. 
Published: September 2023

SummaryThe protective effect of a vaccine against abortion in cows caused by bacteria immunologically related to R‐Brucellae was examined. The results of serological investigations of the blood sera of cows that aborted are briefly reported.ZusammenfassungImmunoprophylaxis und serologische Untersuchungen bei den von Bakterien aus der Mima‐Gruppe und der Gattung Yersinia verursachten Kühen‐AbortenEs wurde die protektive Wirkung einer Vaccine gegenüber Aborte beim Rind, die von mit R‐Brucellen verwandten Bakterien verursacht werden, geprüft. Die Ergebnisse der serologischen Untersuchungen der Blutseren wurden kurzgefaßt mitgeteilt.RésuméImmunoprophylaxie et recherches sérologiques chez des bactéries du groupe Mima et du genre Yersinia provoquant des avortements chez le bovinL'action protectrice d'un vaccin contre les avortements chez le bovin provoqués par des bactéries apparentées aux formes R de brucelles a été testé. Les résultats des recherches sérologiques sanguines sont brièvement résumées.ResumenInmunoprofilaxis y estudios serológicos en los abortos de vacas ocasionados por bacterias del grupo Mima y del género YersiniaSe contrastó la acción protectora de una vacuna frente a abortos en vacas, los cuales son ocasionados por bacterias emparentadas con las brucelas R. Se comunican de forma sucinta los resultados de los estudios serológicos.
Hyperglycaemia aggravates periodontal inflamm‐aging by promoting SETDB1‐mediated LINE‐1 de‐repression in macrophages
Authors: Yue Ziqi , Nie Luningxiao , Ji Ning , Sun Yuezhang , Zhu Kangjian , Zou Haonan , Song Xiuxiu , Chen Jiao , Wang Qi 
Published: September 2023

AbstractAimTo explore whether hyperglycaemia plays a role in periodontal inflamm‐aging by inducing phenotypical transformation of macrophages, as well as the potential mechanism via SET domain‐bifurcated histone lysine methyltransferase 1 (SETDB1).Materials and MethodsA hyperglycaemic mouse model was established using streptozotocin injection. The alveolar bone was analysed using micro‐computed tomography. Periodontal inflamm‐aging was detected using western blotting, quantitative real‐time PCR and immunohistochemical analysis. In vitro, RAW 264.7 macrophages were incubated with various doses of glucose. siRNA or overexpression plasmids were used to determine the regulatory mechanism of SETDB1 in macrophage senescence and inflamm‐aging under hyperglycaemic conditions. Expression and distribution of SETDB1 and long interspersed element 1 (LINE‐1) in gingival tissues of patients with or without diabetes were detected using immunofluorescent staining.ResultsSETDB1 expression in the periodontal tissues of patients and mice with diabetes was down‐regulated compared with that in non‐diabetic controls. SETDB1 deficiency induced senescence‐like phenotypical changes in macrophages, which aggravated periodontal inflamm‐aging in diabetic mice. Furthermore, metformin treatment rejuvenated SETDB1 activity and alleviated the hyperglycaemia‐induced periodontal inflamm‐aging.ConclusionsThe findings of this study show that SETDB1 regulates senescence‐like phenotypical switching of macrophages and is a potential candidate for the treatment of diabetes‐induced periodontal inflamm‐aging.
An empirical study of cold chain issues and performance: Applying structural equation modeling
Authors: Arora Madhu , Kumar Rupesh , Bangwal Deepak , Ahmad Vasim , Negi Saurav 
Published: September 2023

AbstractThe food industry suffers from huge wastage and losses in food products, and reducing this waste and loss is an issue in the food industry. Improvement in cold chain performance will result in the minimization of food losses and wastage. The reason for this review is to look at the causal connection between different issues with cold chain performance through empirical validation. According to the goal of the review, seven theories were proposed dependent on a thorough writing survey on issues in the cold chain of the frozen food industry. Evidence was found for proposed speculations. The results of hypothesis testing showed infrastructural facility, safety and quality, awareness and handling practices, and responsiveness to positively influence cold chain performance while increased efforts are required for appropriate implementation of integration, sustainability, and traceability. While the performance of the supply chain and parameters affecting it has been a critical exploration theme for more than many years, scarcely any examination has been led that centers explicitly on issues considered synergistically.
Three‐dimensional multiscale assembly of phyllosilicates, organics, and carbonates in small Ryugu fragments
Authors: Dionnet Zelia , Rubino Stefano , Aléon‐Toppani Alice , Brunetto Rosario , Tsuchiyama Akira , Lantz Cateline , Djouadi Zahia , Baklouti Donia , Nakamura Tomoki , Borondics Ferenc , Sandt Christophe , Heripre Eva , Troadec David , Mivumbi Obadias , Aléon Jérome , Ternier Theo , Matsumoto Megumi , Amano Kana , Morita Tomoyo , Yurimoto Hisayoshi , Noguchi Takaaki , Okazaki Ryuji , Yabuta Hikaru , Naraoka Hiroshi , Sakamoto Kanako , Tachibana Shogo , Yada Toru , Nishimura Masahiro , Nakato Aiko , Miyazaki Akiko , Yogata Kasumi , Abe Masanao , Okada Tatsuaki , Usui Tomohiro , Yoshikawa Makoto , Saiki Takanao , Tanaka Satoshi , Terui Fuyuto , Nakazawa Satoru , Watanabe Seiichiro , Tsuda Yuichi ,   the Hayabusa2‐Initial‐Analysis Stone team
Published: September 2023

AbstractWe report μm‐scale nondestructive infrared (IR) hyperspectral results (IR computed tomography, IR‐CT) in 3‐D and IR surface imaging, IR‐S) in 2‐D, at SOLEIL) combined with X‐ray nano‐computed tomography analyses (at SPring‐8) performed on eight small Ryugu fragments extracted from mm‐sized grains coming both from touchdown first and second sites. We describe the multiscale assembly of phyllosilicates, carbonates, sulfides, oxides, and organics. Two types of silicates, as well as diverse kinds of organic matter, were detected inside Ryugu material. Their spatial correlations are described to discuss the role of the mineralogical microenvironments in the formation/evolution of organic matter. In particular, we have shown that there is a redistribution of the organic matter diffuse component during aqueous alteration on the parent body, with a preferential circulation among fine‐grained phyllosilicates.
Lack of awareness of neurogastroenterology and motility within medical education: Time to fill the gap
Authors: Butt Mohsin F. , Visaggi Pierfrancesco , Singh Rajan , Vork Lisa 
Published: September 2023

AbstractDisorders of gut–brain interaction (DGBI), previously referred to as functional gastrointestinal disorders, affect 40.3% of adults in the general population and are diagnosed in 34.9% of new adult referrals to secondary care gastroenterology services. Despite their high prevalence, studies published in this issue of Neurogastroenterology and Motility by investigators based in Germany, the UK, and the USA demonstrate a mismatch between the clinical burden of DGBI and their representation in medical school and postgraduate curricula. This review outlines the salient findings of these studies and explores why and how negative perceptions toward DGBI exist, including factors related to misinformation and internalized stigma. The authors propose a selection of strategies to ameliorate physicians' attitudes toward and knowledge of neurogastroenterology and motility including linking trainees with dedicated clinician mentors with an interest in motility, exposing trainees to expert patients who can enhance empathy, extending Balint groups into gastroenterology training, and offering motility apprenticeships in specialist units. Urgent improvements to medical school and postgraduate curricula are required to ensure the longevity of this subspecialty field in gastroenterology, and to ensure the needs of a sizeable proportion of gastroenterology patients are appropriately met.
Salubrinal alleviates cartilage degradation in a rabbit temporomandibular joint osteoarthritis model
Authors: Xu Ting , Shuai Jing , Gu Zhiyuan , Wu Mengjie 
Published: September 2023

AbstractObjectiveTo investigate and explain the beneficial effects of local intra‐articular injection of Salubrinal on temporomandibular joint osteoarthritis (TMJOA) using a rabbit model of anterior disc displacement (ADD).MethodsRabbits were divided and subjected to surgical ADD. Salubrinal was administered by intra‐articular injection in the TMJ every other day for 2 and 4 weeks after operation. Histological examination and TUNEL staining were then performed. Immunohistochemistry, quantitative real‐time PCR, and Western blot analysis were employed to evaluate the expression of endoplasmic reticulum (ER) stress‐related markers, catabolic factors, extracellular matrix proteins, inflammatory factors, and nuclear factor‐kappa B (NF‐κB) activation.ResultsIn the ADD groups, we found that Salubrinal partly reversed condylar cartilage deterioration according to the histological analysis. Salubrinal reduced chondrocytes apoptosis while increased matrix components including Collagen II and Aggrecan. Meanwhile, Salubrinal downregulated the catabolic expression of MMP13, ADAMTS5, VEGF, TNF‐α, and IL‐1β. We also observed that Salubrinal inhibited ER stress activation by reducing the expression of GRP78, CHOP, ATF4, and Caspase‐12. Additionally, Salubrinal suppressed the phosphorylation of NF‐κB.ConclusionThese results indicate that Salubrinal alleviates cartilage degradation following ADD, suggesting that intra‐articular injection of Salubrinal is a potential therapeutic approach for preventing TMJOA.
The foundations of influencing policy and practice: How risk science discourse shaped government action during COVID‐19
Authors: Shaw Duncan , Scully Judy 
Published: September 2023

AbstractCOVID‐19 demonstrated the complex manner in which discourses from risk science are manipulated to legitimize government action. We use Foucault's theory of Governmentality to explore how a risk science discourse shaped national and local government action during COVID‐19. We theorize how national government policymakers and local government risk managers were objectified by (and subjectified themselves to) risk science models, results, and discourses. From this theoretical position we analyze a dataset, including observations of risk science discourse and 22 qualitative interviews, to understand the challenges that national government policymakers, risk scientists, and local government risk managers faced during COVID‐19. Findings from our Foucauldian discourse analysis show how, through power and knowledge, competing discourses emerge in a situation that was disturbed by uncertainty—which created disturbed senders (policymakers and risk scientists) and disturbed receivers (risk managers) of risk science. First, we explore the interaction between risk science and policymakers, including how the disturbed context enabled policymakers to select discourse from risk science to justify their policies. This showed government's sociopolitical leveraging of scientific power and knowledge by positioning itself as being submissive to “follow the science.” Second, we discuss how risk managers (1) were objectified by the discourse from policymakers that required them to be obedient to risk science, and paradoxically (2) used the disturbed context to justify resisting government objectification through their human agency to subjectify themselves and take action. Using these concepts, we explore the foundation of risk science influence in COVID‐19.
How do we ensure a safe ABO recheck process?
Authors: Stephens Laura D. , Allen Elizabeth S. , Bloch Evan M. , Crowe Elizabeth P. , Campbell‐Lee Sally A. , Booth Garrett S. , Kopko Patricia 
Published: September 2023

AbstractBackgroundCollecting a patient's blood in a correctly labeled pretransfusion specimen tube is essential for accurate ABO typing and safe transfusion. Noncompliance with specimen collection procedures can lead to wrong blood in tube (WBIT) incidents with potentially fatal consequences. Recent WBIT events inspired the investigation of how various institutions currently reduce the risk of these errors and ensure accurate ABO typing of patient samples.Materials and MethodsThis article describes the techniques employed at various institutions across the United States to mitigate the risk of misidentified pretransfusion patient specimens. Details and considerations for each of these measures are provided.ResultsSeveral institutions require the order for an ABO confirmation specimen, if indicated, to be generated from the transfusion medicine (TM) laboratory. Others issue a dedicated collection tube that is available exclusively from the TM service. Many institutions employ barcoding for electronic positive patient identification. Some use a combination of these strategies, depending on the locations or service lines from which the specimens are collected.ConclusionThe description of various WBIT mitigation strategies will inform TM services on practices that may be effective at their respective institutions. Irrespective of the method(s) utilized, institutions should continue to monitor and mitigate specimen misidentification errors to promote sustained safe transfusion practices.
ExperimentalCorynebacterium pseudotuberculosismastitis in dairy cows
Authors: Aroch I. , Harmelin A. , Saran A. , Levin D. , Shpigel N. Y. 
Published: September 2023

The inoculation of 2000 colony‐forming units ofCorynebacterium pseudotuberculosisinto one teat canal of each of three cows resulted in severe, chronic, pyogranulomatous mastitis. Within three days the cows had a reduced haematocrit, haemoglobin concentration and red cell count. The anaemia was initially normocytic, normochromic and non‐regenerative, and was associated with a brief peak of neutrophilia; a regenerative response became evident two to three weeks later. Clinical signs of mastitis appeared seven to 14 days after the inoculation, with a peak of high fever, more severe anaemia, a second peak of neutrophilia and the complete cessation of milk production from all quarters; extensive and severe pyogranulomatous mastitis developed in the inoculated quarters. No other lesions were detected postmortem, andC pseudotuberculosiswas cultured from the affected quarters but not from the supramammary lymph nodes and viscera.
Impact of SADC Free Trade Area on Southern Africa’s Intra-Trade Performance: Implications for the African Continental Free Trade Area
Authors: Moyo Busani 
Published: September 2023

The main raison d’être of the Southern African Development Community (SADC) Free Trade Area (FTA) implemented in 2012 was to inter alia boost intra-regional trade and promote regional trade integration. The low levels of growth and mixed trade performance of countries, eight years after, raises questions about the success of the FTA. The success of the recently launched African Continental Free Trade Area (AfCFTA) partly hinges on the performance of the regional FTAs like the SADC FTA. This is because it is unlikely that the African Union through the AfCFTA will achieve continentally what regional economic communities failed to achieve at the regional level. We use a gravity model as well as the difference in difference estimator to evaluate, ex-post, the impact of the SADC FTA on total and sectoral intra-exports. Using data from 2001 to 2019, results show that the full implementation of the SADC FTA did not significantly affect export performance with the export difference between countries that joined the FTA and those that did not being insignificant. These results do not change even when using sectoral exports. JEL Codes: F1, F13, F14, F15
Signaling Effect of Dividend on Firm’s Future Performance: A Study of Select Emerging Economies
Authors: Kanojia Sunaina , Bhatia Bunny Singh 
Published: September 2023

The present study examines the signaling effects of a firm’s dividend policy in developing economies (India, Brazil, China, and Taiwan) from 2010 to 2020 in 4,630 companies’ observations. It highlights that the Indian market indicates greater intensity to the signaling model, though no such reactions were recorded in the Brazilian and Taiwanese markets. Further, the Lintner partial adjustment model reveals that companies in India adjust dividends at a slower rate as compared to other emerging markets like China, Brazil, and Taiwan. We found that the Lintner model is the behavioral consequence of the applicability or non-applicability of dividend signaling theory in these emerging economies. JEL Codes: G35, C32, G15