bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adult Patient Satisfaction with Nursing Care Services and Associated Factors Among Admitted Patients at Saint Paul's Hospital Millennium Medical College, Addis Ababa, Ethiopia, 2022: A Cross-Sectional Study
Authors: Bogale Bantalem Amanu , Ahmed Sindew Mahmud , Gebrekidan Aynie Birhane , Bogale Getachew Amanu 
Published: May 2023

Abstract
Background
Providing holistic nursing care and ensuring patient satisfaction have become essential health performance indicators all across the world. Notwithstanding several efforts to improve patient satisfaction with nursing care, the approach in developing countries, including Ethiopia, is still insufficient. This study was aimed to assess the level of adult patients’ satisfaction and to identify factors affecting satisfaction.
Materials and Methods
This cross-sectional study included 407 participants, who were selected using a simple random sampling technique. The sample was distributed using proportional allocation for each selected adult inpatient department. Participants were interviewed using a modified structured Amharic version of the ‘Newcastle satisfaction with nursing scale’. Data analysis was made by SPSS version 26. Bivariate and multivariable logistic regression analysis was used.
Results
The overall level of patient satisfaction with nursing care services was 54.3%. Respondents who had no formal education (P = 0.010), being male (P = 0.041), free service consumers (P < 0.001), health insurance users (P < 0.001), was significantly associated with satisfaction with nursing care. In addition, patients who had previous admission history (P = 0.001), Governmental workers (P < 0.001), and patients admitted in the medical ward (P = 0.010) were associated with patient dissatisfaction with the nursing care services.
Conclusions and recommendations:
This study revealed that adult patient satisfaction with nursing care services was rated low. Previous admission history, higher education level, paying cash for services, and private and governmental workers were significant predisposing factors to dissatisfaction with nursing care. On the other hand, patients with no formal education, free service consumers and being male were significant predictors of satisfaction with nursing care services. Therefore, it is recommended that the hospital administration better emphasize the needs and expectations of the patient.
Immature mandarin orange extract increases the amount of Hyaluronic acid in human skin fibroblast and keratinocytes
Authors: Furukawa Tomoko , Yokono Chisako , Nomura Yoshihiro 
Published: May 2023

Abstract
Immature mandarin orange is thinned in order to maturation of orange. To use immature mandarin orange as a cosmetic functional material, we investigated the seasonal fluctuation changes in hesperidin and narirutin levels and antioxidant capacity of immature mandarin oranges, and the effects on human skin cells. The contents of hesperidin from Aoshima, Otsu, and Shonan gold, is higher at about a month after flowering. Shonan gold has higher content of narirutin to compere that of Aoshima and Otsu. We found the addition of immature mandarin orange extracts to the human skin fibroblasts and keratinocytes, gene expression level of hyaluronic acid synthase and the hyaluronic acid contents in the medium are higher than that of the control. It was suggested that hesperidin in immature mandarin orange enhances the ability of skin cells to produce hyaluronic acid. Our findings indicate that the immature mandarin orange is a characteristic material on cosmetics and functional foods.
Ketorolac removal through photoelectrocatalysis using TiO2 nanotubes in water system
Authors: Rodríguez Sebastián Oyarzabal , Aceves Luis Erick Coy , Daniel Jesus Eduardo , Sánchez-Salas Jose Luis , Martínez-Huitle Carlos Alberto , Ramírez-Rodrigues Milena Maria , Lopez Monica Cerro 
Published: May 2023

Abstract
Ketorolac, a highly persistent NSAID of environmental concern, was significantly removed from water (80% removal) through photoelectrocatalysis where titanium dioxide nanotubes prepared by Ti foil electrochemical anodization at 30 V were used as photoanodes. 15 mgL-1 ketorolac solutions in a 0.05 M Na2SO4 aqueous medium were subjected to irradiation from a 365 nm light with an intensity of 1 mWcm-2 and under an applied potential of 1.3 V (vs. Hg/Hg2SO4/sat.K2SO4)) at pH 6.0. When each process (photo and electrocatalysis) was carried out separately, less than 20% drug removal was achieved as monitored through UV-vis spectrophotometry. Through scavenging experiments, direct oxidation on the photogenerated holes and oxidation by hydroxyl radicals formation were found to play a key role on ketorolac´s degradation. Chemical oxygen demand (COD) analyses also showed a significant COD decreased (68%) since the initial COD value was 31.3 mg O2/L and the final COD value was 10.1 mg O2/L. A 48% mineralization was also achieved, as shown by total organic carbon (TOC) analyses. These results showed that electrodes based on titania nanotubes are a promising alternative material for simultaneous photocatalytic and electrocatalytic processes in water remediation.
Insights from a cross-sectional binational study comparing obesity among Colombians in their home country and in the U.S.
Authors: Devia Carlos , Flórez Karen R. , Costa Sergio A. , Huang Terry T-K 
Published: May 2023

Abstract
Background: Latinos in the United States (U.S.) represent a heterogeneous minority population disproportionally impacted by obesity. Colombians in the U.S. are routinely combined with other South Americans in most obesity studies. Moreover, most studies among Latino immigrants in the U.S. solely focus on factors in the destination context, which largely ignores the prevalence of obesity and contextual factors in their country of origin, and warrant transnational investigations.
Methods: Using 2013-17 data from the New York City Community Health Survey (NYC CHS, U.S.) and the National Survey of the Nutritional Situation (ENSIN, Colombia), Colombians that immigrated to the U.S. and are living in NYC (n=503) were compared to nonimmigrant Colombians living in their home country (n=98,829). Prevalence ratios (PR) for obesity (BMI ≥30 kg/m2) by place of residence were estimated using multivariable logistic regression adjusting for socio-demographic characteristics and daily consumption of sugar-sweetened beverages.
Results: The prevalence of obesity was 49% greater for immigrant Colombians living in NYC when compared to nonimmigrant Colombians living in in their home country (PR=1.49; 95% CI 1.08, 2.07). Colombian immigrant men in NYC were 72% more likely to have obesity compared to nonimmigrant men living in their home country (PR=1.72; 95% CI 1.03, 2.87). No significant differences were found in the adjusted models among women.
Conclusions: Colombian immigrants in NYC exhibit a higher prevalence of obesity compared to their nonimmigrant counterparts back home and sex strengthens this relationship. More obesity research is needed to understand the immigration experience of Colombians in the U.S. and the underlying mechanisms for sex difference. Public health action focused on women in Colombia and both Colombian men and women immigrants in the U.S. is warranted to avert the long-term consequences of obesity.
Evaluating temporal trends of sand drift potential in Southeast arid areas of Iran, Sistan region
Authors: Rahdari Mohammad Reza , Caballero-Calvo Andrés , Kharazmi Rasoul , Rodrigo-Comino Jesús 
Published: May 2023

Abstract

The Sistan region located in Southeastern Iran is one of the most sensitive areas related to sandstorms and wind erosion in the world. It is well-known that one of the most influential factors in sandstorm interpretation is sand drift potential (SDP), which is directly related to wind speed. However, accurate monitoring of this phenomenon are scarce considering different temporal scales. Therefore, the main aim of this research is to analyze the trend of SDP on monthly and annual scales. Our results showed that monthly variations of SDP obtained the highest and lowest values in July (609 VU) and January (47 VU), respectively. Quicksand moved to the southeast, as well as the directional index fluctuated from 0.88 to 0.94. The annually SDP was equal to 2700 VU, which represents a relatively high value compared to other arid regions of the world. The results of trend analysis applying the Mann–Kendall test showed that there is a positive (1987–2001) and negative (2002–2016) trend, but the positive trend is not significant. Furthermore, the results of Sen’s slope test demonstrated that the negative trend could be obtained with a higher slope during July, September, and Au-gust; as well a positive trend could be obtained with a higher slope during November, December, and June. We concluded that land managers and stakeholders that are in charge to control quicksand using biological and physical methods should pay attention to these trends in arid environment to apply nature-based solutions or control strategies focusing on these temporal sequences.
Multilevel mixed effect analysis of adequate postnatal care in Ethiopia: Evidence from EMDHS, 2019
Authors: Ashemo Mubarek Yesse , Shiferaw Desalegn , Biru Bayise , Feyisa Bikila Regassa 
Published: May 2023

Abstract
Background
The postpartum period is critical for both the mother's and newborn child's health and survival. Rising morbidity and mortality are usually the consequence of absence of adequate, suitable, or timely care during that time period. There is lack of information on the adequacy of postnatal care in Ethiopia and this study was aimed to investigate adequacy of postnatal care and its determinants in the study area.
Methods
In this study we used a cross-sectional dataset from the Ethiopia Mini Demographic and Health Surveys conducted in 2019. A multistage stratified clustered design applied and survey weights were used to take into account the complicated sample design. A multilevel mixed effects logistic regression was fitted on 3772 women who were nested within 305 clusters. The fixed effect models were fitted and expressed as adjusted odds ratios with 95% confidence intervals, while intra-class correlation coefficients, median odds ratio, and proportional change in variance explained measures of variation. As model fitness criteria, the deviance information criterion and the Akaike information criterion were used.
Results
This study found that only 563(16.14%, 95% CI: 16.05–16.24) women had adequate post natal care. Age of between 25–35 years old (AOR = 1.55, 95%CI = 1.04–2.31), secondary level of education (AOR = 2.23, 95%CI = 1.43–3.45), Having parity of between two and four had (AOR = 0.62, 95%CI = 0.42 0.93), having ANC follow up four and above (AOR = 1.74, 95%CI = 1.31–2.33), being residents of Oromia region (AOR = 0.10, 95CI = 0.02–0.43) were strong predictors of adequate postnatal care. ()
Conclusion
The study found that prevalence of adequate PNC in Ethiopia was significantly low. To increase postnatal care adequacy, it was recommended to reinforce existing policies and strategies such as increasing number of antenatal care follow up, and scheduling mothers based on the national postnatal care follow-up protocol.
Substrate type and discovery govern decomposition along a savanna rainfall gradient
Authors: Bunney Katherine , Robertson Mark , Eggleton Paul , Archibald Sally , Parr Catherine 
Published: May 2023

Abstract
Decomposition is the process by which dead plant biomass is recycled and made available again for uptake by other plants. It is largely mediated by microbes and soil invertebrates. Global decomposition studies have demonstrated that decomposition is primarily temperature-driven with rainfall playing a secondary role, although to date, all global decomposition studies have used a single substrate to measure decomposition meaning differences with substrate type may be missed. Here we explored the decomposition of wood, dung and grass along a rainfall gradient (380–650 mm/year) at three savanna sites in South Africa. As the three sites experience a similar temperature range, we effectively controlled for temperature allowing us to explore the effect of rainfall in isolation. We used decomposition bags - with and without termite access - and measured mass loss after set time intervals. We predicted that the absolute decomposition of all three substrates would increase along the rainfall gradient. This assumption held for dung and grass, but we found the reverse for wood. Our study highlights the importance of considering multiple substrates as decomposition patterns and dominant agents can vary. Unexpectedly low wood decomposition at our wettest site suggests that the amount of dead wood available, and therefore probability of discovery by termites, may be an important factor explaining findings from decomposition studies. Resource availability and termite discovery is a neglected subject within decomposition studies and warrants further investigation.
Improved Naive Bayesian Classifier for Financial Risks of Listed Companies
Authors: Xu Yuxi , He Yueqiu , Hua Rui , Xu Jingyong 
Published: May 2023

Abstract
In view of the deficiency of naive Bayesian classifier in the assumption of attribute independence, this paper constructs AdaBoost-naive Bayesian classification model to improve the accuracy of the classifier through continuous machine learning. Through data simulation, it is found that with the increase of sample size, the fluctuation gradually decreases, the accuracy reaches more than 99%, and the trend is stable. When the sample attribute is less than 400, the correct rate of the model reaches more than 95%, and the trend is stable. When the sample attribute is more than 600, the correct rate decreases to about 50%. The fewer classification categories, the higher the correct rate of the model. When the number of classification categories is more than 50, the correct rate is zero. In the empirical analysis on the financial risk rating of listed companies in the cultural industry, the improved naive Bayesian classification algorithm has significantly higher efficiency than naive Bayesian classification algorithm, and the model is more sensitive to samples with higher financial risk. The empirical analysis shows that the improved naive Bayesian classifier has higher accuracy and reliability. Through robustness analysis, it is also found that the improved naive Bayesian model has strong robustness.
Influence of Comorbid Obsessive-Compulsive Symptoms on Subjective Cognitive Symptoms in Patients with Major Depressive Disorder
Authors: Wang Chong-Ze , Xie Qing-fang , Zhang Yao , Meng Mei-Ling , Lu Jia-Jing , Li Xin , Lu Dao-Feng , Chu Min-Yi , Lv Qin-Yu , Yi Zhenghui , Wu Haisu 
Published: May 2023

Abstract
Background: Many clinical studies have shown that patients with major depressive disorder (MDD) or obsessive-compulsive disorder (OCD) display evident cognitive deficits. However, little is known about the impact of these disorders on cognitive symptoms.
Methods: This cross-sectional study was conducted with a convenience sampling method to distribute QR codes as an outpatient service. The Patient Health Questionnaire-9 (PHQ-9) assessed for depressive symptoms, and those with a total score ≥ 5 were selected for the analysis. A total of 218 outpatients with MDD were included. The Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) was used for OCS. MDD patients with a Y-BOCS score ≥ 6 were classified as MDD with comorbid OCS (MDDOC). The Perceived Deficits Questionnaire-Depression (PDQ-D-5) was used to evaluate subjective cognitive symptoms. A multivariate analysis of covariance and regression models was performed to estimate the effects of OCS on cognitive symptoms.
Results: There was no significant difference in cognitive symptoms between MDD alone and MDDOC patients (p＞0.05). In the MDDOC subgroup, both the Y-BOCS score and the subdomain (obsession/compulsion) had significant correlations with the PDQ-5 score (r=0.510, 0.504, 0.428, all p＜0.01, respectively). Further hierarchical regression analyses showed that OCS or the OCS subdomain (compulsion/obsession) contributed to cognitive symptoms (all p﹤0.05), even when controlling for depression severity (p＜0.001; p=0.032; p=0.012, respectively). Moreover,mediation anallysis indicated the ralation between PHQ-9 and subjective cognitive sympton was mediated by OCS.
Conclusions: Our findings suggest there is no significant difference in cognitive symptoms between the MDD alone and the MDDOC groups. However, OCS or OCS subdomain may contribute to subjective cognitive symptoms in MDDOC patients. Notably, when controlling for the severity of depression, comorbid OCS aggravated cognition impairment in the MDDOC group.
Increased expression of Neprilysin is associated with inflammation in Preeclampsia
Authors: Atta Sara , Mekky Rehab , Ibrahim Mostafa , Radwan Eman , Abdallah Mohamed Mahmoud 
Published: May 2023

Abstract
Background
Preeclampsia (PE) is associated with a finely tuned equilibrium between trophoblast cell invasion and fetal-maternal immunological tolerance. An imbalance between pro-inflammatory (IL-6) and anti-inflammatory (IL-10) cytokines is a hallmark of PE. Furthermore, Neprilysin (NEP), a membrane-bound metalloprotease (MME), is vulnerable to an inflammatory environment, a crucial component of PE and plays a significant role in modulating vascular tone.
Objectives
to determine the correlation between NEP (mRNA and protein) level and inflammatory status in patients with preeclampsia compared with healthy pregnant. Identify the role of NEP in evaluating the severity of preeclampsia as well.
Methods
52 pregnant women with preeclampsia were the study group, and 52 pregnant women with normo-tension were the control group. After a caesarean section, placental tissue samples from patients and controls were collected to measure the expression levels of mRNA for IL-6, TGF-, IL-10, and NEP. An enzyme-linked immunosorbent assay was used to check the quantity of NEP protein in the blood samples that were obtained. Prism Graph-Pad Software 5.03 was used to conduct the statistical analysis.
Results
Our research revealed a significant positive correlation among NEP (mRNA and protein) and proinflammatory markers (IL-6, TGF-) levels in patients compared to controls and a significant inverse correlation between NEP and anti-inflammatory cytokines (IL-10). Additionally, this is the first study to find a strong positive correlation between NEP level and preeclampsia severity.
Conclusion
In PE patients, there is a substantial relationship between NEP and the degree of inflammation. Additionally, NEP inhibitors can be used to treat PE and improve prognosis.
Reproducibility and dietary correlates of plasma polyphenols in the JPHC-NEXT Protocol Area study
Authors: Murphy Neil , Sawada Norie , Achaintre David , Yamaji Taiki , Scalbert Augustin , Ishihara Junko , Takachi Ribeka , Nakamura Kazutoshi , Tanaka Junta , Iwasaki Motoki , Iso Hiroyasu , Inoue Manami , Gunter Marc , Tsugane Shoichiro , Mori Nagisa 
Published: May 2023

Abstract
Background In recent years, an increasing number of epidemiological studies have suggested a role of polyphenols in the prevention of chronic diseases. Prospective cohort studies have typically measured polyphenol concentrations in a single blood sample and the reproducibility of plasma polyphenol measurements is largely unknown.Objective We evaluated the reproducibility of 35 plasma polyphenols collected at an interval of 1-year. We also examined correlations of these polyphenols with food group intakes calculated from weighed food records (WFR) and food frequency questionnaire (FFQ).Methods The study included 227 middle-aged participants from the JPHC-NEXT Protocol Area in Japan. We measured 35 polyphenols in plasma collected at two points 1-year apart. Food group intakes were calculated from 12-day WFR and FFQ. For the reproducibility analysis, the intraclass correlation coefficient (ICC) of 35 polyphenol concentrations were examined between the two points. Pearson’s partial correlations was used to assess the correlation between polyphenols and food groups.Results Highest ICCs were observed for enterodiol and tea-originated polyphenols - such as gallic acid, quercetin, epigallocatechin, and kaempferol - and coffee-derived polyphenols, such as caffeic acid, and ferulic acid. For the dietary analyses, moderate correlations were observed for non-alcoholic beverages intake and epigallocatechin, epicatechin, catechin, and gallic acid. For green tea, higher correlations were observed with these polyphenols.Conclusion Plasma concentrations of tea and coffee related polyphenols had good reproducibility over a 1-year period. The correlations between intake of non-alcoholic beverages, particularly green tea, and tea polyphenols, indicated moderate- to high correlations.
The process of spatial frequency information in temporal synchrony perception for audiovisual stimuli
Authors: Takeshima Yasuhiro 
Published: May 2023

Abstract
Temporal synchrony is also important for audiovisual integration. The process of temporal synchrony perception is affected by the temporal information provided by each sensory stimulus. Previous studies have shown that spatial frequency (SF) of visual stimuli alters the perceived timing of subjective simultaneity. However, these studies have been limited to the effects of a single SF component. This study measured and compared the points of subjective simultaneity (PSS) for audiovisual stimuli among low, high, and composited SF components. This experiment utilized a dual-presentation timing task and a ternary response format to eliminate response bias for simultaneity judgment. The results indicated that the PSS of the composition-SF stimuli was between that of the low- and high-SF stimuli. The correlation coefficients showed that the PSS of composition-SF stimuli approximated that of low-SF stimuli better than that in high-SF stimuli. Furthermore, this study more directly indicated that the difference of processing speed with SF modulated PSS values. Future studies are necessary to confirm these findings via visual stimuli with a wider range of SF components.
Wnt/β-catenin pathway is a key signaling pathway to trastuzumab resistance in gastric cancer cells
Authors: Kim Yuna , Bae Yoo Jin , Kim Jie-Hyun , Kim Hyunki , Shin Su-Jin , Jung Da Hyun , Park Hyojin 
Published: May 2023

Abstract
Backgroud:
Trastuzumab is the only approved target agent for the first-line treatment of human epidermal growth factor receptor-2 (HER-2) positive gastric cancer; however, trastuzumab resistance is a major problem in clinical practice. To comprehend the mechanism of trastuzumab resistance, we focused on the Wnt/β-catenin signaling pathway and its influence on the phenotypes and behavior of trastuzumab-resistant gastric cancer cells.
Methods
Trastuzumab-resistant NCI-N87R cells were established in vitro from the human gastric cancer cell line NCI-N87 by dose-escalating repeated trastuzumab treatment. We investigated the phenotypes of NCI-N87R cells, including Wnt signaling pathway activity. Gastric cancer organoid cells were incubated with complete medium and Wnt3a-depletion medium, and their resistance to trastuzumab was compared.
Results
NCI-N87R exhibited stemness and epithelial-mesenchymal transition (EMT)-like phenotypes, along with decreased levels of the epithelial marker E-cadherin and increased levels of the mesenchymal markers Vimentin and Snail along with an increased Wnt signaling pathway activity. When gastric cancer cells were incubated in Wnt3a-conditioned medium. Wnt signaling pathway activity and resistance to trastuzumab increased. Gastric cancer patient-derived organoids incubated in Wnt3a-depletion medium were more susceptible to dose-dependent inhibition of cell viability by trastuzumab than those incubated in complete medium.
Conclusions
Trastuzumab-resistant gastric cancer cells exhibited EMT-like phenotype, and trastuzumab resistance was promoted by the Wnt/β-catenin signaling pathway. The Wnt/β-catenin pathway is a key signaling pathway for trastuzumab resistance in gastric cancer cells.