bluuebunny/crossref_metadata_2025_split huggingface dataset:
Priority conservation areas and a global population estimate for the critically endangered Philippine Eagle
Authors: Sutton L. J. , Ibañez J. C. , Salvador D. I. , Taraya R. L. , Opiso G. S. , Senarillos T. L. P. , McClure C. J. W. 
Published: February 2023

AbstractMany range‐restricted taxa are experiencing population declines, yet we lack fundamental information regarding their distribution and population size. Establishing baseline estimates for both of these key biological parameters is however critical for directing conservation planning for at‐risk range‐restricted species. The International Union for the Conservation of Nature (IUCN) Red List uses three range metrics that define species distributions and inform extinction risk assessments: extent of occurrence (EOO), area of occupancy (AOO) and area of habitat (AOH). However, calculating all three metrics using standard IUCN approaches relies on a geographically representative sample of locations, which for rare species is often spatially biased. Here, we apply model‐based interpolation using Species Distribution Models (SDMs), correlating occurrences with remote‐sensing covariates, to calculate IUCN range metrics, protected area coverage and a global population estimate for the Critically Endangered Philippine Eagle (Pithecophaga jefferyi). Our final range wide continuous SDM had high predictive accuracy (continuous Boyce Index = 0.934) and when converted to a binary model estimated an AOH as 28 624 km2, a maximum EOO as 617 957 km2, and a minimum EOO as 275 459 km2, with an AOO as 53 867 km2. Based on inferred habitat from the AOH metric, we estimate a global population of 392 breeding pairs (range: 318–447 pairs), or 784 mature individuals, across the Philippine Eagle global range. Protected areas covered 32% of AOH, 13% less than the target representation, with the continuous model identifying key habitat as priority conservation areas. We demonstrate that even when occurrences are geographically biased, robust habitat models can quantify baseline IUCN range metrics, protected area coverage and a population size estimate. In the absence of adequate location data for many rare and threatened taxa, our method is a promising spatial modelling tool with widespread applications, particularly for island endemics facing high extinction risk.
Poisonings from hydrocarbon inhalant misuse in Australia
Authors: Berling Ingrid , Chiew Angela , Brown Jared 
Published: February 2023

AbstractBackground and aimsInhalational misuse of volatile substances has been a significant public health concern because of the risk of sudden death and associated chronic complications such as encephalopathy. The Australian Government released a Consensus‐based clinical practice guideline in 2011 on the management of volatile substance use in Australia, which noted a lack of available data particularly on harms. This study aimed to measure (1) the number of calls received by the New South Wales Poisons Information Centre (NSWPIC) regarding inhalational hydrocarbon exposures or poisonings and (2) the number of unintentional deaths reported to the National Coronial Information System (NCIS) in Australia.Design, setting, cases, measurementsWe performed a retrospective review of all recreational inhalational hydrocarbon exposure calls to the NSWPIC between 1 January 2010 and 31 December 2020. A search was made of the NCIS database in all states and territories over the same period to determine the number of non‐intentional inhalational hydrocarbon‐related deaths in Australia.FindingsBetween January 2010 and December 2020, there were 752 primary calls made to the NSWPIC regarding hydrocarbon use or exposure. Age or age bracket was recorded in 748 cases, with 508 (67%) calls involving children or adolescents. Over the same time, there were 58 unintentional deaths involving the recreational use of inhalational hydrocarbons. The median age at death was 23 years (interquartile range = 15–30 years), and 72% (42 cases) were male. Cause of death was predominately acute suffocation/asphyxia, encephalopathy related to chronic use, cardiac arrest likely from sudden sniffing syndrome or thermal injuries secondary to unintentional fires sparked by the volatile agents.ConclusionAlthough death and cardiac arrest are uncommon among people in Australia who misuse hydrocarbons for recreational use, the deaths and cardiac arrests tend to occur in adolescents.
Down syndrome and biological treatments in dermatology: Efficacy and safety in our real‐life experience and review of literature
Authors: Tancredi Vittorio , Licata Gaetano , Calabrese Giulia , Buononato Dario , De Rosa Alina , Argenziano Giuseppe , Gambardella Alessio 
Published: February 2023

AbstractDown syndrome (DS) is the most common chromosomal disorder; several dermatological conditions are common in these patients; among them, psoriasis and atopic dermatitis can be frequently encountered. From 2017 to today, we retrospectively identified 4 adults and 3 under 18‐year‐old patients treated with biological drugs, from our research database. The first endpoint of this study was to evaluate whether the biological drugs work in these special population, and a secondary endpoint was to evaluate any loss of efficacy or any side effects during follow‐up. All patients were treated with biological drugs experience resolution of their psoriasis. Mean PASI (Psoriasis Area Severity Index), BSA (Body Surface Area) and DLQI (Dermatology Life Quality Index) at baseline were 20, 16.5 and 25. At week 4, mean PASI, BSA and DLQI decreased, respectively, to 8, 6 and 12, while at week 24, mean values were, respectively, 3, 1.3 and 1. The patients that started therapy earlier, at week 52, do not have signs of recurrence and side effects. We highlighted that no official guidelines exist to approach these patients, from a literature evaluation the most employed drugs are anti‐TNFα and in particular adalimumab. In our experience, the new anti‐interleukin drugs seem to be well‐tolerated, with no sides effect, good compliance and no loss of efficacy.
Suboptimal care was frequent in severe child physical abuse cases and was mainly related to delayed diagnoses and ineffective secondary prevention
Authors: Blangis Flora , Malorey David , Gras‐Le Guen Christèle , Vabres Nathalie , Picherot Georges , Ricaud Patricia , Chalumeau Martin , Launay Elise 
Published: February 2023

AbstractAimOur aim was to assess suboptimal care before a diagnosis of severe child physical abuse in western France.MethodsA confidential inquiry was carried out, based on children under 6 years of age who were hospitalised in the Nantes regional university hospital from 2016 to 2018. Two researchers retrospectively reviewed the medical records of all the children who were reported to the authorities for suspected severe child physical abuse. Two experts determined the optimality of care and identified the main categories of suboptimal care.ResultsThe median age of the 94 children included in the study was 8 months. A fifth of them had intra‐cranial injuries and a quarter had fractures. One child died and a third had severe sequelae at hospital discharge. Included children frequently (37%) received suboptimal care before the diagnosis of severe CPA and this fell into two categories: delayed diagnosis was experienced by 17% and ineffective secondary prevention by 22%.ConclusionSuboptimal care for severe child physical abuse was frequent and fell into two categories: delayed diagnosis and ineffective secondary prevention. These results can help us to design corrective actions.
Comparing music‐ and food‐evoked autobiographical memories in young and older adults: A diary study
Authors: Jakubowski Kelly , Belfi Amy M. , Kvavilashvili Lia , Ely Abbigail , Gill Mark , Herbert Gemma 
Published: February 2023

AbstractPrevious research has found that music brings back more vivid and emotional autobiographical memories than various other retrieval cues. However, such studies have often been low in ecological validity and constrained by relatively limited cue selection and predominantly young adult samples. Here, we compared music to food as cues for autobiographical memories in everyday life in young and older adults. In two separate four‐day periods, 39 younger (ages 18–34) and 39 older (ages 60–77) adults recorded their music‐ and food‐evoked autobiographical memories in paper diaries. Across both age groups, music triggered more frequent autobiographical memories, a greater proportion of involuntary memories, and memories rated as more personally important in comparison to food cues. Age differences impacted music‐ and food‐evoked memories similarly, with older adults consistently recalling older and less specific memories, which they rated as more positive, vivid, and rehearsed. However, young and older adults did not differ in the number or involuntary nature of their recorded memories. This work represents an important step in understanding the phenomenology of naturally occurring music‐evoked autobiographical memories across adulthood and provides new insights into how and why music may be a more effective trigger for personally valued memories than certain other everyday cues.
Optimization of cancer immunotherapy on the basis of programmed death ligand‐1 distribution and function
Authors: Zou Wei , Luo Xin , Gao Mengyuan , Yu Chang , Wan Xueting , Yu Suyun , Wu Yuanyuan , Wang Aiyun , Fenical William , Wei Zhonghong , Zhao Yang , Lu Yin 
Published: February 2023

Programmed cell death protein‐1 (PD‐1)/programmed death ligand‐1 (PD‐L1) immune checkpoint blockade as a breakthrough in cancer immunotherapy has shown unprecedented positive outcomes in the clinic. However, the overall effectiveness of PD‐L1 antibody is less than expected. An increasing number of studies have demonstrated that PD‐L1 is widely distributed and expressed not only on the cell membrane but also on the inside of the cells as well as on the extracellular vesicles secreted by tumour cells. Both endogenous and exogenous PD‐L1 play significant roles in influencing the therapeutic effect of anti‐tumour immunity. Herein, we mainly focused on the distribution and function of PD‐L1 and further summarized the potential targeted therapeutic strategies. More importantly, in addition to taking the overall expression abundance of PD‐L1 as a predictive indicator for selecting corresponding PD‐1/PD‐L1 monoclonal antibodies (mAbs), we also proposed that personalized combination therapies based on the different distribution of PD‐L1 are worth attention to achieve more efficient and effective therapeutic outcomes in cancer patients.LINKED ARTICLESThis article is part of a themed issue on Cancer Microenvironment and Pharmacological Interventions. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v181.2/issuetoc
Language and reading impairments are associated with increased prevalence of non‐right‐handedness
Authors: Abbondanza Filippo , Dale Philip S. , Wang Carol A. , Hayiou‐Thomas Marianna E. , Toseeb Umar , Koomar Tanner S. , Wigg Karen G. , Feng Yu , Price Kaitlyn M. , Kerr Elizabeth N. , Guger Sharon L. , Lovett Maureen W. , Strug Lisa J. , van Bergen Elsje , Dolan Conor V. , Tomblin J. Bruce , Moll Kristina , Schulte‐Körne Gerd , Neuhoff Nina , Warnke Andreas , Fisher Simon E. , Barr Cathy L. , Michaelson Jacob J. , Boomsma Dorret I. , Snowling Margaret J. , Hulme Charles , Whitehouse Andrew J. O. , Pennell Craig E. , Newbury Dianne F. , Stein John , Talcott Joel B. , Bishop Dorothy V. M. , Paracchini Silvia 
Published: February 2023

AbstractHandedness has been studied for association with language‐related disorders because of its link with language hemispheric dominance. No clear pattern has emerged, possibly because of small samples, publication bias, and heterogeneous criteria across studies. Non‐right‐handedness (NRH) frequency was assessed in N = 2503 cases with reading and/or language impairment and N = 4316 sex‐matched controls identified from 10 distinct cohorts (age range 6–19 years old; European ethnicity) using a priori set criteria. A meta‐analysis (Ncases = 1994) showed elevated NRH % in individuals with language/reading impairment compared with controls (OR = 1.21, CI = 1.06–1.39, p = .01). The association between reading/language impairments and NRH could result from shared pathways underlying brain lateralization, handedness, and cognitive functions.
Rigorous theory‐based intervention research is the bold action needed to address oral health disparities and inequities
Authors: Riddle Melissa , Rice Elise 
Published: February 2023

AbstractThe Consensus Statement about behavioral and social sciences in oral health encourages future research to draw on testable theories that specify causal pathways that reflect the complex nature of oral health. In this commentary, we amplify the importance of explicit and well‐specified theory in oral health intervention research, acknowledging that problematic use of theory has limited its utility in developing effective public health interventions. Also, we affirm the need to focus on determinants of oral health—and health inequities—most likely to drive meaningful change, and to understand the causal pathways that connect drivers of change from the individual to the global level. We view theory‐based, causal mechanisms research as a powerful approach to building successful public health interventions, and suggest resources to inspire such research, including exemplary studies, methodologies, and collaborative initiatives that facilitate strong theory‐based public health research.
Behavioural and social oral health intervention research: Looking to the future
Authors: Borrelli Belinda 
Published: February 2023

AbstractBehavioural and social oral health intervention has made great strides in intervention development and testing. Future research should focus on applying successful methods and interventions of disciplines outside oral health to oral health research and practice as well as focus on raising the visibility of oral health research by applying our established methods and interventions to outside domains. Behavioural and social oral health is strategically positioned to be a leader across several research domains, perhaps most prominently in digital health, disparities and developing and testing theories and frameworks, given the progress that has already been made, and significant investment in these areas from funders like the National Institute for Craniofacial Research.
Cytohistological correlation and risk stratification of salivary gland lesions using the Milan System for Reporting Salivary Gland Cytopathology: A tertiary care centre experience
Authors: Kumar Tarun , Tewari Prerna , Nigam Jitendra Singh , Bharti Shreekant , Surabhi  , Sinha Ruchi , Bhadani Punam Prasad 
Published: February 2023

AbstractIntroductionSalivary gland neoplasms account for approximately 5% of head and neck tumours. The cytomorphology of fine needle aspiration material helps determine the preoperative assessment and risk stratification. The Milan System for Reporting Salivary Gland Cytopathology (MSRSGC) was developed to improve communication between the laboratory and treatment provider.Aims and objectiveIn the present study, we stratified all salivary gland lesions according to the MSRSGC and evaluated each category's concordance and risk of malignancy (ROM).Materials and methodsThis was a 5 year retrospective study. First, all cases were assigned to one of the six MSRSGC categories. Then, following cytohistological correlation, the concordance rates and ROM were calculated based on the final histopathology report.ResultsA total of 354 cases were identified, with ages ranging from 2 to 88 years and the commonest age group was the 3rd to 4th decades. Categories I, II, III, IVA, IVB, V, and VI comprised 5.37% (19/354), 26.84% (95/354), 1.13% (04/354), 51.41% (182/354), 1.98% (07/354), 1.13% (04/354), and 12.15% (43/354) of the cases, respectively. The overall concordance rate between the cytological and histopathological diagnoses was 81.25% (65 out of 80 cases), with the sensitivity, specificity, positive predictive value, and negative predictive value at 43.48%, 96.49%, 83.33%, and 80.88%, respectively.ConclusionThe MSRSGC provides a better objective and structured way to communicate with the health care provider. In our study, the overall concordance rate was observed in 62/80 cases, with maximum concordance seen in categories III, IVB, and V of the MSRSGC.
A latent class analysis of patterns of tobacco and cannabis use in Australia and their health‐related correlates
Authors: Lim Carmen C. W. , Leung Janni K. Y. , Gravely Shannon , Gartner Coral , Sun Tianze , Chiu Vivian , Chung Jack Y. C. , Stjepanović Daniel , Connor Jason , Scheurer Roman W. , Hall Wayne , Chan Gary C. K. 
Published: February 2023

AbstractIntroductionThe shifting landscape in Australia's tobacco and cannabis policies and emerging new products and modes of administration may increase experimentation and the risks of addiction to these drugs.MethodsWe analysed cross‐sectional data from the 2019 National Drug Strategy and Household Survey (n = 22,015) of Australians aged 14 and above. Latent class analysis was used to identify distinct groups based on types of tobacco and cannabis products used. The socio‐demographic, health‐rated correlates and past‐year substance use of each latent class was examined.ResultsA four‐class solution was identified: co‐use of tobacco and cannabis (2.4%), cannabis‐only (5.5%), tobacco‐only (8.0%) and non‐user (84.0%). Males (odds ratio [OR] range 1.5–2.9), younger age (OR range 2.4–8.4), moderate to high psychological distress (OR range 1.3–3.0), using illicit substances in the last year (OR range 1.41–22.87) and high risk of alcohol use disorder (OR range 2.0–21.7) were more likely to be in the tobacco/cannabis use classes than non‐users. Within the co‐use class, 78.4% mixed tobacco with cannabis and 89.4% had used alcohol with cannabis at least once.Discussion and ConclusionsApproximately 16% of respondents used tobacco or cannabis, or both substances, and no major distinct subgroups were identified by the use of different product types. Mental health issues and the poly‐substance use were more common in the class who were co‐users of cannabis and tobacco. Existing policies need to minimise cannabis and tobacco‐related harms to reduce the societal burden associated with both substances.
Indications and prescribing patterns of antiseizure medications in children in New Zealand
Authors: Ali Shayma , Stanley James , Davis Suzanne , Keenan Ngaire , Scheffer Ingrid E. , Sadleir Lynette G. 
Published: February 2023

AbstractAimTo determine indications and prescribing patterns for antiseizure medications (ASMs) in children by age, sex, and socioeconomic status.MethodThis retrospective study searched the New Zealand database of ASM prescriptions dispensed to individuals aged 18 years or under during 2015 in three regions of New Zealand (48% paediatric population). Medical records were reviewed by a paediatric neurologist for indication. ASMs were grouped into old or new (1993 onwards).ResultsIn total, 2594 children (0 to 18 years, mean age 11 years 2 months, median 12 years; 51% male) were dispensed 3557 ASMs for seizures (76%), pain (6%), headache (5%), mental health (3%), and movement disorders (2%). After 10 years of age, lamotrigine was more likely and valproate less likely to be prescribed in females than males. No sex difference was observed for valproate prescriptions for non‐seizure indications. Topiramate prescriptions increased in adolescent females. Prescriptions for non‐seizure indications increased from 7% in children aged 6 years or under to 31% in 16‐ to 18‐year‐olds. The proportion of children receiving a new ASM compared to an old ASM was greater in children from higher than lower socioeconomic areas.InterpretationOur results highlight a need for focused ASM teratogenicity messaging to clinicians prescribing ASMs for non‐seizure indications. In addition, to improve equity of epilepsy care, it is critical for health policies to consider socioeconomic factors that impact on ASM prescribing.
Mortality after transvenous lead extraction: A risk prediction model for sustainable care delivery
Authors: Narducci Maria Lucia , Ruscio Eleonora , Nurchis Mario Cesare , Domenico Pascucci , Scacciavillani Roberto , Bencardino Gianluigi , Perna Francesco , Pelargonio Gemma , Massetti Massimo , Damiani Gianfranco , Crea Filippo 
Published: February 2023

AbstractBackground and AimsTransvenous lead extraction (TLE) has become a pivotal part of a comprehensive lead management strategy, dealing with a continuously increasing demand. Nonetheless, the literature about the long‐term impact of TLE on survivals is still lacking. Given these knowledge gaps, the aim of our study was to analyse very long‐term mortality in patients undergoing TLE in public health perspective.MethodsThis prospective, single‐centre, observational study enrolled consecutive patients with cardiac implantable electronic device (CIED) who underwent TLE, from January 2005 to January 2021. The main goal was to establish the independent predictors of very long‐term mortality after TLE. We also aimed at assessing procedural and hospitalization‐related costs.ResultsWe enrolled 435 patients (mean age 70 ± 12 years, with mean lead dwelling time 6.8 ± 16.7 years), with prevalent infective indication to TLE (92%). Initial success of TLE was achieved in 98% of population. After a median follow‐up of 4.5 years (range: 1 month–15.5 years), 150 of the 435 enrolled patients (34%) died. At multivariate analysis, death was predicted by: age (≥77 years, OR: 2.55, CI: 1.8–3.6, p < 0.001), chronic kidney disease (CKD) defined as severe reduction of estimated glomerular filtration rate (eGFR <30 mL/min/1.73 m2, OR: 1.75, CI: 1.24–2.4, p = 0.001) and systolic dysfunction assessed before TLE defined as left ventricular ejection fraction (LVEF) <40%, OR: 1.78, CI 1.26–2.5, p = 0.001. Mean extraction cost was €5011 per patient without reimplantation and €6336 per patient with reimplantation respectively.ConclusionsOur study identified three predictors of long‐term mortality in a high‐risk cohort of patients with a cardiac device infection, undergoing successful TLE. The future development of a mortality risk score before might impact on public health strategy.