bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prospective comprehensive evaluation of an elastic-band beard cover for filtering facepiece respirators in healthcare workers
Authors: Williams Daryl Lindsay , Kave Benjamin , Bodas Charles , Begg Fiona , Roberts Megan , Ng Irene 
Published: July 2023

AbstractObjective:To undertake a healthcare-based multimodal evaluation of the combination of filtering facepiece respirator (FFR) with the elastic-band beard cover technique, including quantitative fit test (QNFT) results, skills assessment, and usability assessment.Design and setting:We conducted a prospective study through the Respiratory Protection Program at the Royal Melbourne Hospital from May 2022 to January 2023.Participants:Healthcare workers who required respiratory protection and could not shave for religious, cultural, or medical reasons.Intervention:Online education and personal face-to-face training on the use of FFR with the elastic-band beard cover technique.Results:Among 87 participants (median beard length 38 mm; interquartile range [IQR], 20–80), 86 (99%) passed 3 QNFTs consecutively with the elastic-band beard cover under a Trident P2 respirator and 68 (78%) passed 3 QNFTs consecutively with a 3M 1870+ Aura respirator. The first QNFT pass rate and the overall fit factors were significantly higher when using the technique than without the elastic-band beard cover. Most participants displayed a high skill level in their donning, doffing, and user seal-check techniques. Of 87 participants, 83 (95%) completed the usability assessment. The overall ease of use, comfort, and overall assessment were rated highly.Conclusions:The elastic-band beard cover technique can provide safe and effective respiratory protection for bearded healthcare workers. The technique was easily taught, comfortable, well tolerated and accepted by healthcare workers, potentially allowing them full participation in the workforce during pandemics with airborne transmission. We recommend further research and evaluation of this technique in a broader health workforce.
Fairness is based on quality, not just quantity
Authors: Zenkić Jay , Millet Kobe , Mead Nicole L. 
Published: July 2023

Abstract
According to decades of research, whether negotiations succeed depends on how much of the stake each person will get. Yet, real-world stakes often consist of resources that vary on quality, not just quantity. While it may appear obvious that people should reject qualitatively inferior offers, just as they reject quantitatively unequal offers, it is less clear why. Across three incentive-compatible studies (N = 1,303) using the ultimatum game, we evaluate three possible reasons for why people reject qualitatively unequal negotiation offers (that are 50% of the stake): fairness, mere inequality, or badness. Data across the three studies are consistent with the fairness account. Casting doubt on the possibility that people reject qualitatively unequal offers merely because they are ‘bad’, Studies 1 and 2 found that participants were more likely to reject the same coins when these were inferior (e.g., 200 × 5¢ coins) to the negotiation partner’s coins (e.g., 5 × $2 coins) than when both parties received the same undesirable coins (e.g., both received 200 × 5¢ coins). Supporting a fairness explanation, rejection rates of the qualitatively inferior offer were higher when the proposal came from a human (vs. a computer), suggesting that rejection stemmed in part from a desire to punish the negotiation partner for unfair treatment (Study 3). Nevertheless, some participants still rejected the unequal offer from a computer, suggesting that mere inequality matters as well. In sum, the findings highlight that quality, not just quantity, is important for attaining fair negotiation outcomes.
A conceptual model of multi-scale formation processes of open-air Middle Paleolithic sites in the arid Negev desert, Israel
Authors: Oron Maya , Roskin Joel , Avni Yoav , Porat Naomi , Aladjem Emil , Yegorov Dmitry , Vardi Jacob , Hovers Erella 
Published: July 2023

AbstractOpen-air surface accumulations and scatters of material cultural remains often are perceived as less-reliable archaeological archives, where it is difficult to distinguish anthropogenic versus geogenic formation processes or to assess their specific effects on the integrity of archaeological records. Here we analyze the depositional histories of three Middle Paleolithic open-air sites in the Negev desert of Israel, combining archaeological and geomorphological methods to create a conceptual model of multi-scale effects on the archaeological remains. Relying on the long research history in archaeology and geomorphology in the Negev, we show that integration of archaeological and geomorphological methodologies provides nuanced insights to our understanding of the archaeological record. The links established between regional and local geomorphic processes and lithic taphonomy by applying such a multi-scale analysis further allow back-tracking environmental processes from flint taphonomic attributes. Placing each site within the range of regional and local processes of exposure and burial by using informed and critically evaluated data helps to create a robust regional archaeological data base. We suggest that our approach is useful in other arid zone contexts and may have implications for understanding Pleistocene population movements across such regions.
The association of childhood trauma with depressive and negative symptoms in recent onset psychosis: a sex-specific analysis
Authors: Enthoven Anne-Sophie D. , Gangadin Shiral S. , de Haan Lieuwe , Veling Wim , de Vries Erik F. J. , Doorduin Janine ,   HAMLETT and OPHELIA Consortium, Begemann Marieke J. H. , Sommer Iris E. C. 
Published: July 2023

AbstractBackgroundChildhood trauma may impact the course of schizophrenia spectrum disorders (SSD), specifically in relation to the increased severity of depressive or negative symptoms. The type and impact of trauma may differ between sexes. In a large sample of recent-onset patients, we investigated the associations of depressive and negative symptoms with childhood trauma and whether these are sex-specific.MethodsA total of 187 first-episode psychosis patients in remission (Handling Antipsychotic Medication: Long-term Evaluation of Targeted Treatment study) and 115 recent-onset SSD patients (Simvastatin study) were included in this cross-sectional study (men:n= 218; women:n= 84). Total trauma score and trauma subtypes were assessed using the Childhood Trauma Questionnaire Short Form; depressive and negative symptoms were rated using the Positive And Negative Symptoms Scale. Sex-specific regression analyses were performed.ResultsWomen reported higher rates of sexual abuse than men (23.5%v.7.8%). Depressive symptoms were associated with total trauma scores and emotional abuse ratings in men (β: 0.219–0.295;p≤ 0.001). In women, depressive symptoms were associated with sexual abuse ratings (β: 0.271;p= 0.011). Negative symptoms were associated with total trauma score and emotional neglect ratings in men (β: 0.166–0.232;p≤ 0.001). Negative symptoms in women were not linked to childhood trauma, potentially due to lack of statistical power.ConclusionsDepressive symptom severity was associated with different types of trauma in men and women with recent-onset SSD. Specifically, in women, depressive symptom severity was associated with childhood sexual abuse, which was reported three times as often as in men. Our results emphasize the importance of sex-specific analyses in SSD research.
NARRATOLOGY IN THE PRACTICE SESSION MODEL OF ELLIOTT CARTER'S STRING QUARTET NO. 5
Authors: Carey Christian 
Published: July 2023

AbstractElliott Carter's programme notes for his String Quartet No. 5 describe it as being about the embodiment of human interaction within the rehearsal process. This article develops this concept, evaluating the musical figures that are foreshadowed by the fragments that Carter suggests are rehearsal outtakes. Certain motives are reiterated and developed through slight variations, thus exemplifying the rehearsal process, and perhaps the editorial process, in detail. Interactions within this model are suggestive of the character types that Carter has delineated in his previous string quartets, notably No. 2. Using the Practice Session model also alludes to the real-life circumstances of the preparation of previous quartets by ensembles, and anecdotes about the Juilliard Quartet's rehearsals for the premiere of the String Quartet No. 3 can enhance a narratological understanding of the No. 5's construction. Finally, String Quartet No. 5 is considered as an example of one of the transitional works that initiate Carter's late style and its consolidation of material; its use of all-interval chords, their subsets and supersets reflects the constructive elements of human interaction that Carter has stressed as a principal thematic element.
BETWEEN AUDIATION AND EKPHRASIS: PASCAL DUSAPIN'S ‘FALSE TRAILS’
Authors: Metcalf Thomas 
Published: July 2023

AbstractThis article investigates the prolific deployment of images in Pascal Dusapin's scores of the mid to late 1990s. Using Edwin Gordon's concept of ‘audiation’ and Siglind Bruhn's concept of ‘musical ekphrasis’, as well as Neal Curtis’ ideas on the agency and liveness of images, interdisciplinary interpretations of three Dusapin works are offered, using the score image as the main analytical starting point. Beginning with his Piano Études and Loop, these analyses will demonstrate how the score images, derived from the study of ‘catastrophe theory’, prefigure the control of various musical parameters relating to the relationship of variables in this mathematical concept and its forms. An analysis of String Quartet No. 4, notable for its use of both a score image (of a machine) and textual quotation (from Samuel Beckett's Murphy), will then demonstrate how the visual can interact with the verbal to construct a plurality of musical metaphors. The article concludes by positing that Dusapin's elusiveness on the role and function of the images within his work could amount to what W. T. J. Mitchell describes as ‘ekphrastic fear’: an anxiety that the composer's success amalgamating image and music might have broken down the ontological boundary between them.
VOICE WITHOUT SPEAKER: HUMAN SPEECH SYNTHESIS IN ACOUSTIC INSTRUMENTAL CONTEXTS
Authors: Chen Andrew 
Published: July 2023

AbstractThis article provides an overview of compositional practices that invoke representations of the human voice by acoustic means, without the presence of actual human speakers, and, in identifying the limitations and deficiencies of extant practice, proposes a new method or methodological basis for achieving the same phenomenon, to different ends. Clarence Barlow's seminal synthrumentation method forms a central point of discussion; when considered alongside the work of, among others, Mayuzumi, Grisey and Ablinger, it becomes clear that, in existing synthrumental (or instrumental synthesis) practices, the innate inharmonic components of target material for reproduction have largely been discarded or overlooked. After a brief overview of the basic linguistic and perceptual features of speech, a new method designed to evoke whispered speech, with inharmonicity in mind, is demonstrated.
Extraction and Analysis of Three‐Dimensional Morphological Features of Centimeter‐Scale Rocks in Zhurong Landing Region
Authors: Li Y. , Xiao Z. , Ma C. , Zeng L. , Zhang W. , Peng M. , Li A. 
Published: July 2023

AbstractChina's first Mars rover, Zhurong, has carried out an exploration mission in southern Utopian Planitia. As rocks and their three‐dimensional (3D) morphology are essential for studying the geological characteristics of the Martian surface, this paper presents an approach for automatically extracting 3D rocks from stereo rover images. With our approach, 6,185 cm‐scale rocks are extracted using the Zhurong NaTeCam images, with the F1‐score achieving 91.86%. Approximate 3D morphological features are then calculated for each rock, and the statistical result shows that small rocks in centimeters make up the majority. Comparative morphological analyses of rocks in different areas show that landscape type affects the number of rocks but has no clear relationship to the proportions of rocks of different sizes. The outcrops of sedimentary rocks, the predominant type of rocks in the Zhurong landing area, and the float rocks are distributed differently regarding all morphological features, making the size‐frequency distribution of rocks around craters significantly different from other areas. Further comparative analysis with the Bonneville crater ejecta rocks extracted from the Spirit rover data is also conducted. Some similarities between the Zhurong outcrop rocks and the Bonneville crater ejecta rocks are found in 2D compactness. Meanwhile, the Bonneville crater ejecta rocks have a more scattered distribution in sphericity than both the float and outcrop rocks in the Zhurong landing area, indicating that the shapes of the Bonneville crater ejecta rocks may be more diverse. In addition, the sphericity is found to converge with height for rocks in both landing areas.
The Fate of Nitrogen During Agricultural Intensification in East Africa: Nitrogen Budgets in Contrasting Agroecosystems
Authors: Tully K. L. , Hickman J. E. , Russo T. A. , Neill C. , Matata P. , Nyadzi G. , Mutuo P. , Palm C. A. 
Published: July 2023

AbstractThe intensification of agricultural systems in sub‐Saharan Africa (SSA) is necessary to reduce poverty and improve food security, but increased nutrient applications in smallholder systems could have negative consequences for water quality, greenhouse gas emissions, and air quality. We tracked nitrogen (N) inputs and measured maize (Zea mays) biomass, grain yields, N leaching, and nitric oxide (NO) and nitrous oxide fluxes from a clayey soil in Yala, Kenya and a sandy soil in Tumbi, Tanzania, with application rates of 0, 50, 75, 100, 150, and 200 kg N ha−1 yr−1 over two cropping seasons. Maize yields were 4.5 times higher in Yala than Tumbi, but yields plateaued at both sites with fertilizer applications at or above 100 kg N ha−1 yr−1. Partial N budgets in Yala were typically negative, meaning more N was exported in maize biomass plus grain or lost from the system than was added in fertilizer. In Tumbi, N budgets were negative at lower fertilizer levels but positive at higher fertilizer levels. At both sites most (96%) of the N was lost through maize biomass/grain removal and N leaching. Fertilizer additions at or less than 50 kg N ha−1 yr−1 on these two contrasting sites resulted in minor gaseous N losses, and fertilizer additions less than 200 kg N ha−1 yr−1 caused relatively little change to N leaching losses. This indicates that the modest increases in fertilizer use required to improve maize yields will not greatly increase cropland N losses.
Superresolution structured illumination microscopy reconstruction algorithms: a review
Authors: Chen Xin , Zhong Suyi , Hou Yiwei , Cao Ruijie , Wang Wenyi , Li Dong , Dai Qionghai , Kim Donghyun , Xi Peng 
Published: July 2023

AbstractStructured illumination microscopy (SIM) has become the standard for next-generation wide-field microscopy, offering ultrahigh imaging speed, superresolution, a large field-of-view, and long-term imaging. Over the past decade, SIM hardware and software have flourished, leading to successful applications in various biological questions. However, unlocking the full potential of SIM system hardware requires the development of advanced reconstruction algorithms. Here, we introduce the basic theory of two SIM algorithms, namely, optical sectioning SIM (OS-SIM) and superresolution SIM (SR-SIM), and summarize their implementation modalities. We then provide a brief overview of existing OS-SIM processing algorithms and review the development of SR-SIM reconstruction algorithms, focusing primarily on 2D-SIM, 3D-SIM, and blind-SIM. To showcase the state-of-the-art development of SIM systems and assist users in selecting a commercial SIM system for a specific application, we compare the features of representative off-the-shelf SIM systems. Finally, we provide perspectives on the potential future developments of SIM.
On-demand light-driven release of droplets stabilized via a photoresponsive fluorosurfactant
Authors: Cheng Guangyao , Xiao Qinru , Kuan Chit Yau , Ho Yi-Ping 
Published: July 2023

AbstractWater-in-oil droplets have emerged as promising microreactors for high-throughput biochemical analysis due to their features of reduced sample consumption and automated operation. For a typical screening application, droplets are often trapped for continuous monitoring of the reaction over an extended period, followed by the selective retrieval of targeted droplets based on the after-effect of biochemical reactions. While techniques for droplet trapping are well developed, retrieval of targeted droplets mainly demands complicated device fabrication or sophisticated control. Herein, facile and rapid selective droplet release is achieved by utilizing a new class of photoresponsive fluorosurfactant based on plasmonic nanoparticles. The intense photothermal response provided by this novel photoresponsive fluorosurfactant is capable of vaporizing the fluorocarbon oil at the droplet interface under laser illumination, resulting in a bubble releasing a trapped droplet on demand. A fully automated fluorescence-activated droplet release platform has also been developed to demonstrate its potential for droplet-based large-scale screening applications.
Physical symptoms and brain morphology: a population neuroimaging study in 12,286 pre-adolescents
Authors: Estévez-López Fernando , Kim Hannah H. , López-Vicente Mónica , Legerstee Jeroen S. , Hillegers Manon H. J. , Tiemeier Henning , Muetzel Ryan L. 
Published: July 2023

AbstractPhysical symptoms, also known as somatic symptoms, are those for which medical examinations do not reveal a sufficient underlying root cause (e.g., pain and fatigue). The extant literature of the neurobiological underpinnings of physical symptoms is largely inconsistent and primarily comprises of (clinical) case-control studies with small sample sizes. In this cross-sectional study, we studied the association between dimensionally measured physical symptoms and brain morphology in pre-adolescents from two population-based cohorts; the Generation R Study (n = 2649, 10.1 ± 0.6 years old) and ABCD Study (n = 9637, 9.9 ± 0.6 years old). Physical symptoms were evaluated using continuous scores from the somatic complaints syndrome scale from the parent-reported Child Behavior Checklist (CBCL). High‐resolution structural magnetic resonance imaging (MRI) was collected using 3-Tesla MRI systems. Linear regression models were fitted for global brain metrics (cortical and subcortical grey matter and total white matter volume) and surface-based vertex-wise measures (surface area and cortical thickness). Results were meta-analysed. Symptoms of anxiety/depression were studied as a contrasting comorbidity. In the meta-analyses across cohorts, we found negative associations between physical symptoms and surface area in the (i) left hemisphere; in the lateral orbitofrontal cortex and pars triangularis and (ii) right hemisphere; in the pars triangularis, the pars orbitalis, insula, middle temporal gyrus and caudal anterior cingulate cortex. However, only a subset of regions (left lateral orbitofrontal cortex and right pars triangularis) were specifically associated with physical symptoms, while others were also related to symptoms of anxiety/depression. No significant associations were observed for cortical thickness. This study in preadolescents, the most representative and well-powered to date, showed that more physical symptoms are modestly related to less surface area of the prefrontal cortex mostly. While these effects are subtle, future prospective research is warranted to understand the longitudinal relationship of physical symptoms and brain changes over time. Particularly, to elucidate whether physical symptoms are a potential cause or consequence of distinct neurodevelopmental trajectories.
The pharmacological bases for repurposing statins in depression: a review of mechanistic studies
Authors: De Giorgi Riccardo , Rizzo Pesci Nicola , Rosso Gianluca , Maina Giuseppe , Cowen Philip J. , Harmer Catherine J. 
Published: July 2023

AbstractStatins are commonly prescribed medications widely investigated for their potential actions on the brain and mental health. Pre-clinical and clinical evidence suggests that statins may play a role in the treatment of depressive disorders, but only the latter has been systematically assessed. Thus, the physiopathological mechanisms underlying statins’ putative antidepressant or depressogenic effects have not been established. This review aims to gather available evidence from mechanistic studies to strengthen the pharmacological basis for repurposing statins in depression. We used a broad, well-validated search strategy over three major databases (Pubmed/MEDLINE, Embase, PsychINFO) to retrieve any mechanistic study investigating statins’ effects on depression. The systematic search yielded 8068 records, which were narrowed down to 77 relevant papers. The selected studies (some dealing with more than one bodily system) described several neuropsychopharmacological (44 studies), endocrine-metabolic (17 studies), cardiovascular (6 studies) and immunological (15 studies) mechanisms potentially contributing to the effects of statins on mood. Numerous articles highlighted the beneficial effect of statins on depression, particularly through positive actions on serotonergic neurotransmission, neurogenesis and neuroplasticity, hypothalamic-pituitary axis regulation and modulation of inflammation. The role of other mechanisms, especially the association between statins, lipid metabolism and worsening of depressive symptoms, appears more controversial. Overall, most mechanistic evidence supports an antidepressant activity for statins, likely mediated by a variety of intertwined processes involving several bodily systems. Further research in this area can benefit from measuring relevant biomarkers to inform the selection of patients most likely to respond to statins’ antidepressant effects while also improving our understanding of the physiopathological basis of depression.
Molecular regulation and therapeutic implications of cell death in pulmonary hypertension
Authors: Wang Enze , Zhou Sijing , Zeng Daxiong , Wang Ran 
Published: July 2023

AbstractPulmonary hypertension (PH) is a clinical and pathophysiological syndrome caused by changes in pulmonary vascular structure or function that results in increased pulmonary vascular resistance and pulmonary arterial pressure, and it is characterized by pulmonary endothelial dysfunction, pulmonary artery media thickening, pulmonary vascular remodeling, and right ventricular hypertrophy, all of which are driven by an imbalance between the growth and death of pulmonary vascular cells. Programmed cell death (PCD), different from cell necrosis, is an active cellular death mechanism that is activated in response to both internal and external factors and is precisely regulated by cells. More than a dozen PCD modes have been identified, among which apoptosis, autophagy, pyroptosis, ferroptosis, necroptosis, and cuproptosis have been proven to be involved in the pathophysiology of PH to varying degrees. This article provides a summary of the regulatory patterns of different PCD modes and their potential effects on PH. Additionally, it describes the current understanding of this complex and interconnected process and analyzes the therapeutic potential of targeting specific PCD modes as molecular targets.