bluuebunny/crossref_metadata_2025_split huggingface dataset:
Health literacy and experience of the Yemeni migrants with the Dutch healthcare system: a qualitative study
Authors: Al-Tamimi Abdulhakeem , Parić Martina , Groot Wim , Pavlova Milena 
Published: January 2023

Abstract
Background and aim
The Netherlands is receiving increasing numbers of Yemeni refugees due to the ongoing war in Yemen. Since there is a lack of knowledge about access to health care by migrants, this study investigates the experiences of Yemeni refugees with the Dutch healthcare system from a health literacy perspective.
Methods
Qualitative semi-structured in-depth interviews were conducted among 13 Yemeni migrants in the Netherlands, who were invited using convenience and snowball sampling. Inductive and deductive thematic analyses were conducted on their health literacy and experience with the Dutch healthcare system.
Results
The participants knew how to use primary and emergency care, and were aware of health problems related to smoking, physical inactivity, and an unhealthy diet. However, some participants lacked an understanding of health insurance schemes, vaccination, and food labels. They also experienced language barriers during the first months after arrival. Furthermore, they preferred to postpone seeking mental health care. They also showed mistrust towards general practitioners and perceived them as uncaring and hard to convince of their complaints.
Discussion and conclusion
Yemeni migrants are well-acquainted with many aspects of Dutch healthcare, disease prevention, and health promotion. However, trust in healthcare providers, vaccination literacy and mental health awareness must improve. Therefore, it is suggested to ensure more ethnic-based community mobilisation strategies that can be used to improve trust in the healthcare system and facilitate mental healthcare acceptance.
Grass shrimp parasites use complimentary life histories to avoid a conflict of interest
Authors: Finn Robert P , Buck Julia C 
Published: January 2023

Abstract
A conflict of interest occurs when parasites manipulate the behavior of their host in contradictory ways. In grass shrimp (Palaemonetes pugio), trematode parasites cause the shrimp to be more active than usual around predators, while bopyrid isopod parasites elicit the opposite response. Since these parasites are altering the host’s behavior in opposing directions, a conflict of interest should occur in doubly infected shrimp. Natural selection should favor attempts to resolve this conflict through avoidance, killing, or sabotage. In a field survey of shrimp populations in four tidal creeks in the Cape Fear River, we found a significant negative association between the two parasites. Parasite abundance was negatively correlated in differently sized hosts, suggesting avoidance as a mechanism. Subsequent mortality experiments showed no evidence of early death of doubly infected hosts. In behavior trials, doubly infected shrimp did not show significantly different behavior from other infection statuses, suggesting that neither parasite sabotages the manipulation of the other. Taken together, our results suggest that rather than sabotaging one another directly, bopyrid and trematode parasites reduce conflict by preferentially infecting differently sized hosts. Because grass shrimp exist at high biomass in salt marsh ecosystems and are infected at high prevalence, our findings have implications for ecosystem structure and function.
Neurodevelopmental trajectory in a cohort of Very Low Birth Weight Infants at preschool age: a prospective observational study.
Authors: Battajon Nadia , Bechini Chiara , De Osti Federica , Galletti Anna , Frigo Anna Chiara , Lago Paola 
Published: January 2023

Abstract
Background. Preterm birth is a risk factor for a baby’s neurological development. Preterm children have unusual neurodevelopmental profiles with executive, visual-motor functions, fine and gross motor skills, language and behavior that affect learning.
To analyze the neurodevelopmental trajectory of a cohort of very low birth weight infants (VLBWIs) admitted to the neonatal intensive care unit (NICU) between 2014 and 2016, followed until pre-school age.
Method. This is an observational cohort study. Infants were followed at birth and after NICU discharge at two- and four-year follow-ups. The two-year assessment was conducted with Bayley III, and at four years with the WPSSI and ABC Movement two scales.
Results. The cohort consisted of 207 subjects with a mean gestational age (GA) of 28.9 (SD 2.6) weeks, and a mean birth weight of 1097.2 (SD 281.7) grams. At two years, children without disabilities were 90 (59.6%), those with mild disabilities 47 (31.1%), and those with moderate disabilities 14 (9.3%); at four years, 58.4% of children without previous disabilities, presented problems with verbal tests (WPSSI-ICV) and manual dexterity (MD): aiming and grasping (ME) and balance (E) at mABC2. There was significant alteration in processing speed (IVE) (p < 0.001). Further, there was a strong correlation between IVE and DM (correlation = 0.47 p < 0.001) and between IVE and ME (correlation=0.27, p = 0.0059).
Conclusions. With pre-school neurodevelopmental assessment, given our cohort of ex-VLBWIs, we found more than half the children free of disability at two years, as they had presented a deficit that often involves oculo-motor coordination and processing speed.
Island Pedicle Flap: A versatile and dependable technique for covering small to medium sized facial defects
Authors: MBBCh Abubaker Elamin , MBBCh Hussein Ahmed , Fiala Mohamed S. , El-Sawy Abdelhamid , Ezzat Abdelrahman 
Published: January 2023

AbstractBackground:Facial skin defects following the excision of cutaneous neoplasia may present a reconstruction challenge. The island pedicle flap offers a versatile and dependable tool for reconstruction of a variety of facial defects. The aim was to evaluate our experience with the utility of the island pedicle flap in reconstruction of facial skin defects.Methods:A retrospective assessment on 48 patients was small- to medium-sized facial skin defects were reconstructed with island pedicle flaps. The data was collected between November 2018 and December 2020. The reconstructions were performed in consideration of the relaxed skin tension lines and facial aesthetic unit concept.Results:All defects were successfully covered with island pedicle flaps. The defect sizes varied from 0.2cm2to 9.5cm2. The outcome for the safety margins were as follows; 4 cases with 0.3 cm margin, 22 cases with 0.4 cm margin, 16 cases with 0.5 cm margin and 6 cases with 0.6 cm margin. Excision margins per pathology were compared to the BAD criteria; with 40 cases meeting the BAD criteria and 8 cases not. For this study, we focussed on two FACE-Q Skin Cancer Module scales. ‘Satisfaction with Facial Appearance’ had a highest score on the scale of 93% satisfaction and 19% of patients scored 71-82% on the scale. Regarding ‘Appraisal of Scar’, 79% of patients rated their outcome 82-100% on the scale.Conclusion:Considering the simplicity and safety of island pedicle flaps, this flap has been proven a reliable and a valuable tool.
NRF2 Transcriptionally Regulates Caspase-11 Expression to Activate HMGB1 Release by Hepatocytes
Authors: KHAMBU BILON , Cai Genxiang , Liu Gang , Bailey Niani , Mercer Arissa , Baral Kamal , Ma Michelle , Chen Xiaoyun , li Yu , Yin Xiao-Ming 
Published: January 2023

Abstract
Injury or stress can induce intracellular translocation and extracellular release of nuclear HMGB1, a typical danger-associated molecular pattern (DAMP) molecule known to participate in inflammation and other pathological processes. Active release of HMGB1 can occur from stimulated macrophages. However, whether and how active release of HMGB1 could occur from epithelial cells such as hepatocytes is less clear. We previously had shown that active release of HMGB1 can occur from autophagy impaired hepatocytes, and it depended on the inflammasome but how the inflammasome was activated was not known. Here we report that persistent activation of transcription factor NRF2 under the autophagy deficient condition led to transcriptional upregulation of Caspase-11 expression, which could then activate the CASPASE-1inflammasome. Using chromatin immunoprecipitation (CHIP) and luciferase-based reporter assays, we show that NRF2 directly binds to the Caspase-11 promoter and transcriptionally increase the expression of Caspase-11. Genetic deletion of Caspase-11 in autophagy-deficient livers represses the release of HMGB1 and its pathological consequence, ductular cell proliferation. Consistently, deletion of NLRP3, which can activate CASPASE-1 mediated inflammasomes under other types of signals, did not prevent HMGB1 release and ductular cell proliferation in autophagy deficient livers. Surprisingly, while cleavage of GASDEMIN D occurred in autophagy-deficient livers its deletion did not prevent the HMGB1 release, suggesting that CASPASE-11-mediated inflammasome activation may also engage in a different mechanism for HMGB1 release by the autophagy deficient hepatocytes. Collectively, this work reveals the novel role of NRF2 in transcriptional upregulation of Caspase-11 and in inflammasome activation to promote active release of HMGB via a non-Gasdermin D mediated avenue in hepatocyte.
Liquid tumor microenvironment enhances WNT signaling pathway of peritoneal metastasis of gastric cancer
Authors: Xu Huawei , Hao Zhibin , Wang Yujie , Zhang Deng , Li Jie , Chen Ling , Yao Ninghua , Qian Binbin , Peng Xiaobo , Zhan Xianbao 
Published: January 2023

Abstract
Gastric cancer remains one of the most prevalent tumors worldwide and peritoneal metastasis is responsible for approximately 60% death in advanced gastric cancer patients. However, the underlying mechanism of peritoneal metastasis is poorly understood. We have established organoids derived from malignant ascites (MA) of gastric cancer patient and noticed that MA supernatant could strongly increase colony formation of organoids. We realized the interaction between exfoliated cancer cells (ECCs) and tumor microenvironment contributes to peritoneal metastasis. We designed a medium component control test which proved that exosomes derived from MA could not enhance the growth of organoids. Using western blotting assay as well as Immunofluorescence and confocal imaging, our data showed WNT signaling pathway is upregulated by high concentration of WNT ligands (wnt3a and wnt5a), which was verified by ELISA. Conversely, suppressing WNT signaling pathway diminishes the growth promoting function of MA supernatant. This result implicates WNT signaling pathway as a potential therapeutic target for peritoneal metastasis of gastric cancer.
Thermal energy savings during cord fiber spinning
Authors: Palátka Jan , Mayer Karel , Pexa Martin , Čedík Jakub , Holubek Michal 
Published: January 2023

Abstract
The demand for high-strength grade fibers and consumption of viscose fibers shows increasing tendency and growing trends in use of this product. Regenerated cellulose-based fibers of various properties are produced in order to meet all needs using new production technologies developed especially in recent years. One of the key processes in fiber spinning is continuous drying before final winding on spools. The manufacturing methods used for viscose fibers allows production of various types, parameters and specifications of fibers. It is therefore increasingly necessary to implement and standardize a drying concept to stabilize subprocess in a continuous production manufacturing as much as possible within the desired parameters of the final product. These activities and methods embody concepts for production of the highest quality fibers suitable to both producers and users. Currently, the concept of drying viscose fibers in a continuous production process is a problem that affects its final shape and quality properties such as commercial weight, linear density and tensile properties of all products and lengths for staple fibers as well as shrinkage and twisting for yarns of fibers. Due to that, development of technology enabling maximum stabilization of the drying process to achieve long-term sustainable final fiber quality parameters was adopted as a strategic project, including incorporation of efficient solutions for the overall energy intensity of this process in order to reduce the manufacturing carbon footprint by 23.81%. The production of viscose fibers and the project also aims to achieve significant energy savings up to 24 509.9 GJ·year-1.
Cycle-consistent Generative Adversarial Network for computational hematoxylin-and-eosin staining of fluorescence confocal microscopic images of basal cell carcinoma tissue
Authors: Bagheri Mahmoud , Ghanadan Alireza , Daneshpazhooh Maryam , Atyabi Fatemeh , Hejazi Marjaneh 
Published: January 2023

Abstract
Background
Histopathology based on Hematoxylin-and-Eosin (H&E) staining is the gold standard for basal cell carcinoma (BCC) diagnosis but requires lengthy and laborious tissue preparation. Fluorescence confocal microscopy (FCM) enables fluorescence detection and high-resolution imaging in less time and with minimal tissue preparation. This work proposes a deep learning model for the computational staining of FCM images based on an unsupervised approach, which correlates color with H&E images.
Methods
In this study, we investigated the utility of FCM on BCC tissue sections stained with Acridine Orange (AO) and computationally colored to simulate H&E dyes. We adopted Cycle-consistent Generative Adversarial Network (CycleGAN), an unsupervised framework, for computational staining. The dataset consists of unpaired and unannotated thousands of FCM and H&E patches from whole slide images of BCC tissue sections. CycleGAN includes two forward and backward GANs that are coupled together and complete a cycle to ensure a reliable transformation between the two domains. In addition to the adversarial and cycle consistency constraints, a saliency constraint was employed to enhance the correct mapping direction between FCM and H&E images and avoid appearance distortions of the image content.
Results
The generated H&E-like images from FCM through this CycleGAN model were visually and quantitatively similar to real H&E images. Computationally stained images had skin tissue characteristics. The trained models showed a high performance in the structure preservation of the original image when comparing the source and reconstructed images. Quantitative metrics (by Fréchet Inception Distance) showed that CycleGAN could improve the similarity of training images by up to 63% after mapping images from a source domain to a target domain.
Conclusion
FCM could expand the application and usefulness of rapid tissue analysis. Thus, using the CycleGAN model for computational staining is beneficial for diagnostic applications while simplifying laboratory staining procedures. The proposed approach has significant potential in clinical computational staining and advanced computer-aided histology image analysis.
Research on Group Decision Making of Public Space Renovation in Old Communities in China Based on Participant Conflict View
Authors: Li Yang , Zheng Wei , Wang Jingxue , Zhao Lu 
Published: January 2023

Abstract
Background. With the widespread renovation of public space in older communities, we not only face the problems such as limited space and great difficulty in renovation, but also faces the challenges of more diversified decision makers and more market-oriented renovation methods. This further results in frequent community contradictions, hinders the smoothness of the renovation and upgrading, and also affects the improvement of the physical and mental health of residents in old community.
Methods. In this paper, a decision model for renovation of public space in old communities under the minimum conflict constraint is constructed based on fuzzy preference information. The incomplete preference matrix is used to estimate the missing value, the similarity is used for group clustering, and the conflict degree is measured according to the distance entropy to make the decision.
Findings. The feasibility of the multi-agent decision-making method for the renovation of old communities established in this study is demonstrated by case study, and the renovation conflicts of public spaces in old communities can be mediated by changing the weight of decision-making subjects in the modified preference matrix.
Conclusion. In this study, multi-agent preference, incomplete information and multi-decision scheme are integrated into the decision-making of renovation scheme, which can resolve the conflicts of public decision-making and improve the efficiency and quality of decision-making.
Soil Depth Can Modify the Contribution of Root Structure to Root Decomposition
Authors: TANG YINGZHOU , Liu Xin , Lian JingWei , Cheng Xuefei , Zhang Jinchi , Wang G. Geoff 
Published: January 2023

Abstract
Aims
Changes in root structure and soil depth affect root decomposition. However, due to soil opacity, many variables of root structure have not been well studied and even measured.
Methods
To investigate the effects of soil depth and the characteristics of root structure on root decomposition, soil samples (In-situ soil core of 10cm diameter and 60cm length drilled by soil auger in October 2020) were collected in Cunninghamia lanceolata and Pinus taeda plantations (40 years), at six soil depths (0-60cm, every 10cm). The root structure in the in-situ soil cores was analyzed using CT scans and specialized analysis software.
Results
Root volume, shape, and connectivity were significantly higher in the 0–10 cm soil depth than in the 10-60cm soil depths, but root length and tortuosity were significantly lower than in the 50-60cm soil depth (p༜0.05). The SEM shows that different stand types influenced root biomass and thus root decomposition directly or indirectly through the characteristics of stand types. Root structure variables affected root biomass and thus root decomposition indirectly. Root biomass contributed the most to root decomposition in Cunninghamia lanceolata (20.19%) and Pinus taeda (32.26%) plantations. The contribution of root structure variables to root decomposition exceeded 50% in the 20–30 cm and 40–50 cm soil depths.
Conclusions
Our findings suggested that the contribution and influence of root structure variables on root decomposition rate varies with soil depth. It deserves more consideration in our future studies.
Sex Differences in Cardiac Rehabilitation Barriers among Non-Enrollees in the Context of Lower Gender Equality
Authors: Firoozabadi Mahdieh Ghanbari , Mirzaei Masoud , Grace Sherry L , Vafaeinasab Mohammadreza , Dehghani-Tafti Maryam , Sadeghi Abbas , Asadi Zohre , Basirinezhad Mohammad Hasan 
Published: January 2023

Abstract
Background
Despite the benefits of cardiac rehabilitation (CR), it remains under-utilized, particularly by women. This study compared CR barriers between non-enrolling men and women in Iran, which has among the lowest gender equality globally.
Methods
In this cross-sectional study, CR barriers were assessed via phone interview in phase II non-attenders from March 2017 to February 2018 with the Persian version of the Cardiac Rehabilitation Barriers Scale (CRBS-P). T-tests were used to compare scores, with each of 18 barriers scored out of 5, between men and women.
Results
357 (33.9%) of the sample of 1053 were women, and they were older, less educated and less often employed than men. Total mean CRBS scores were significantly greater in women (2.37 ± .37) than men (2.29 ± .35; p < .001). The top CR barriers among women were cost (3.35, P < 0.001), transportation problems (3.24, P < 0.001), distance (3.21, P < 0.001), comorbidities (2.97, P < 0.001), low energy (2.41, P < 0.001), finding exercise as tiring or painful (2.22, P = 0.018), and older age (2.27, P = 0.001). Men rated "already exercise at home or in community" (2.69, P = 0.001), time constraints (2.18, P < 0.001) and work responsibilities (2.24, P = 0.001) as greater CR barriers than women.
Conclusion
Women had greater barriers to CR participation than men. CR programs should be modified to address women’s needs. Home-based CR tailored to women’s exercise needs and preferences should be considered.
A novel FePO4 nanosized fertilizer is as efficient as triple superphosphate in sustaining the growth of cucumber plants
Authors: Ciurli Andrea , Giagnoni Laura , Sega Davide , Pastorelli Roberta , Varanini Zeno , Renella Giancarlo , Zamboni Anita 
Published: January 2023

Abstract
Background

Behaviour of nanofertilizers in plant-soil system can be different from that of conventional chemical fertilizers due to their peculiar chemical-physical properties, and their effectiveness is still poorly understood.

Methods

We tested the effectiveness of a FePO4 NF in sustaining the growth of cucumber plants in a pot experiment, compared to a conventional TSP fertilizer. Plants were grown for 28 d on a P deficient soil and growth parameters, nutrient concentrations in plant tissues, P availability in soil, activity of enzymes involved in C, N, P and S mineralization and the structure of the soil microbial communities were determined.

Results and conclusions

Results showed no significant differences in dry weight, leaf area, SPAD index and root growth between NF and TSP fertilized plants. Conversely, P availability in soil and P content in plant tissues at the end of the experiment was significantly higher after TSP than NF fertilization, whereas no major differences were observed for other nutrients. Among the measured soil enzyme activities, acid phosphatase, β-glucosidase and arylsulfatase activities presented similar values between NF- and TSP-treated soils, the alkaline phosphatase activity presented higher values in TSP- than in NF-fertilized soil, whereas the protease activity showed higher values in NF- than in TSP-fertilized soils. Microbial community structure of NF- and TSP-fertilized soils showed significant differences for archaeal, bacterial and fungal communities although the microbial community profiles clustered generally closer to each other among all treatments. We concluded that the tested FePO4 NF can be an efficient alternative to conventional TSP fertilizers.