bluuebunny/crossref_metadata_2025_split huggingface dataset:
Duration and dosing of systemic corticosteroids for acute exacerbation of COPD, protocol for a systematic review with meta-analysis of randomized trials and cohort studies
Authors: Yin Raymond , Wang Yiyang , Ying Yue , Ding Mutian , Ouyang Yunqing , Yuan Emily , Ye Daniel , Yuan Shirley , Li Guanying , Hou Winston 
Published: August 2023

Purpose
Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is a leading cause of deterioration in patients with otherwise stably controlled COPD. Treatments of AECOPD often require the use of corticosteroid therapy in conjunction with bronchodilators and antibiotics. However, the duration and dosage of corticosteroids still remain unclear. We propose to perform this systematic review and meta-analysis of all available randomized control trials (RCTs) and observational cohort studies to comprehensively assess the efficacy and safety of different corticosteroid duration and dosing regimen in the current body of evidence.

Methods
We will search MEDLINE, EMBASE, CENTRAL via Ovid as well as CINAHL and Web of Science for available literature comparing different corticosteroid duration and dosage in the treatment of AECOPD. We will perform title and full text screening in duplicate, then extract relevant data using a pre-piloted extraction form. We will define short duration as less than 14-day duration of treatment and long duration as greater than 14-day treatment. We will report mortality difference as our primary outcome, with additional comparisons in incidence of re-exacerbation, hospital length of stay, lung function, incidence of hyperglycemia and infection. We will perform risk of bias assessment using the ROB2.0 and ROBINS-I tool, as well as the GRADE assessment to assess the quality of evidence.

Results
We will publish the full results of our systematic review and meta-analysis in a peer-reviewed journal.

Discussions
To our knowledge, this represents an updated and most comprehensive review of the literature comparing different duration and dosing regimen of corticosteroid treatments in AECOPD, as we will include both RCTs and observational studies without date or language restrictions. We aim to validate prior meta-analyses and study findings on the efficacy of short duration corticosteroid therapy over longer treatments and to inform future research directions in dosing regimens.
A Clinico-Pathological Correlation of Breast Lumps in a Tertiary Care Centre
Authors: Irine Kuzhipallil Mathew  , Ajesh Gopal  
Published: August 2023

BACKGROUND
Breast lump is one of the most prevalent ailments that women face. Mostly these lumps are benign, but breast malignancy is the most common form of cancer and is the second leading cause of malignancy deaths in women. Fibroadenoma is the most common benign breast mass and invasive ductal carcinoma is the most common malignancy. Delay in the detection causes the malignancy to progress to an advanced stage. Early detection of malignancies in initial stages is done using triple test to decrease mortality. Incidence of breast cancer can be reduced by 30% by the routine mammographic screening of healthy women. We wanted to correlate the clinical and pathological diagnosis in patients presenting with palpable breast lumps and assess the reliability of clinical examination as a pre-procedural diagnostic tool in this study.
METHODS
A prospective observational study was done in a total of 100 women. Detailed clinical history and examination were done and then compared to histopathological results. The final results were statistically analyzed.
RESULTS
The clinical examination exhibited a sensitivity of 97.96% and a specificity of 96.08% for the identification of cancer when the data were considered collectively. The clinical examination's positive predictive value was 95.84%, and its negative predictive value was 98.08%.
CONCLUSIONS
A significant correlation was also observed between the clinical diagnosis and final pathological diagnosis. So routine clinical examination would definitely be helpful in early diagnosis.
Characteristics of spatial use and importance of landscape features for recovering populations of Eurasian lynx (Lynx lynx)
Authors: Potočnik Hubert , Črtalič Jaka , Kos Ivan , Skrbinšek Tomaž 
Published: August 2023

Following the extirpation from Central and Southeastern Europe by the end of the 19th century, Eurasian lynx (Lynx lynx) was reintroduced in the Alps and Dinarics. The recovering population sizes fluctuated over the years; however, they remained relatively small and isolated since their distribution after the establishment has not significantly expanded by natural colonization. One of the most radical changes to the landscape of Europe over the past centuries has been the creation of vast urban and agricultural areas and subsequent extension of infrastructure, causing increasingly fragmented landscape, especially for weak dispersers like lynx. There is a pressing need to establish greater connectivity between the genetically isolated populations, particularly throughout the Alps and Dinarics, to achieve a viable metapopulation structure. In the paper, we review scientific knowledge on Eurasian lynx spatial requirements and behaviour, and critically evaluate the methods used. Apart from habitat suitability and connectivity studies, we also provide a review of lynx home range sizes and movement activity, including dispersion. We present habitat suitability model constructed to examine suitable habitat for recovering Dinaric - SE Alpine population and compare home range sizes of lynx from Dinarics in Slovenia with other lynx populations in Europe. Future considerations for lynx conservation should include the impact of climate change, protection of corridor areas, reducing impact of barriers and, if needed, “complement” dispersal via translocations to achieve viable pan-European lynx metapopulation in the future.
On some generalized Simpson type inequalities for (α,m)-coordinated
convex functions in context of q
1
q
2-calculus
Authors: Gulshan Ghazala , Ali Muhammad Aamir , Hussain Rashida , Sadiq Asad , Budak Hüseyin 
Published: August 2023

Abstract
In the current investigation, we offer the generalized version of

q
1

⁢

q
2

{q_{1}q_{2}}

-Simpson’s type inequalities via

(
α
,
m
)

{(\alpha,m)}

-coordinated convex functions. To validate their generalized behavior, we demonstrate the link between our outcomes and the already derived ones. Moreover, we provide some application to special means of positive real numbers to support our findings. The principal outcomes raised in this investigation are extensions and generalizations of the comparable results in the history on Simpson’s inequalities for coordinated convex functions.
Research progress of AMP-activated protein kinase and cardiac aging
Authors: Qiu Zhengqi , Li Yufei , Fu Yancheng , Yang Yanru 
Published: August 2023

Abstract
The process of aging is marked by a gradual deterioration in the physiological functions and functional reserves of various tissues and organs, leading to an increased susceptibility to diseases and even death. Aging manifests in a tissue- and organ-specific manner, and is characterized by varying rates and direct and indirect interactions among different tissues and organs. Cardiovascular disease (CVD) is the leading cause of death globally, with older adults (aged >70 years) accounting for approximately two-thirds of CVD-related deaths. The prevalence of CVD increases exponentially with an individual’s age. Aging is a critical independent risk factor for the development of CVD. AMP-activated protein kinase (AMPK) activation exerts cardioprotective effects in the heart and restores cellular metabolic functions by modulating gene expression and regulating protein levels through its interaction with multiple target proteins. Additionally, AMPK enhances mitochondrial function and cellular energy status by facilitating the utilization of energy substrates. This review focuses on the role of AMPK in the process of cardiac aging and maintaining normal metabolic levels and redox homeostasis in the heart, particularly in the presence of oxidative stress and the invasion of inflammatory factors.
Capillary surfaces: Stability, index and curvature estimates
Authors: Hong Han , Saturnino Artur B. 
Published: August 2023

Abstract
In this paper, we investigate the connection between the index and the geometry and topology of capillary surfaces.
We prove an index estimate for compact capillary surfaces immersed in general 3-manifolds with boundary.
We also study noncompact capillary surfaces with finite index and show that, under suitable curvature assumptions, such surface is conformally equivalent to a compact Riemann surface with boundary, punctured at finitely many points.
We then prove that a weakly stable capillary surface immersed in a half-space of

R
3

\mathbb{R}^{3}

which is minimal or has a contact angle less than or equal to

π
/
2

\pi/2

must be a half-plane.
Using this uniqueness result, we obtain curvature estimates for strongly stable capillary surfaces immersed in a 3-manifold with bounded geometry.
Microscopic computed tomography aided finite element modelling as a methodology to estimate hygroexpansion coefficients of wood: a case study on opposite and compression wood in softwood branches
Authors: Florisson Sara , Hartwig Marie , Wohlert Malin , Gamstedt Erik Kristofer 
Published: August 2023

Abstract
Microscopic X-ray computed tomography (XµCT) aided finite element (FE) modelling is a popular method in material science to relate material properties to heterogeneous microstructures. Recently, a methodology was developed for the XµCT aided FE modelling of wood, which characterises the process from specimen preparation to estimation of material properties. In the current research, this methodology is tested on branches of Norway spruce (Picea abies (L.) Karst.) to estimate the hygroexpansion coefficients of opposite (OW) and compression wood (CW). These properties are largely unknown and have engineering implications. The study is complemented by measurements of density, moisture content (MC) and elastic moduli. Results showed that the methodology assisted in the design of an integrated process and the identification of bottlenecks. It was seen that the level of detail of the numerical model had a strong influence on the obtained hygroexpansion properties. CW from branches showed higher density and longitudinal shrinkage coefficients, and elastic moduli less affected by MC. These differences are unlikely caused by MC, but more likely by the characteristics of the microstructure.
Information Scientists’ Motivations for Research Data Sharing and Reuse
Authors: Shutsko Aliaksandra , Stock Wolfgang G. 
Published: August 2023

Abstract
What are the motivations and sought gratifications leading information science researchers to share and to reuse research data? Research data are both datasets and supplementary materials such as interview guides or questionnaires. The theoretical backgrounds of this study are the Lasswell Formula of Communication, the Uses and Gratifications Theory, and the Self-determination Theory, which formed the basis for the construction of an interview guide and the interpretation of the interview transcripts. We performed 11 in-depth interviews with German information scientists, all with experiences with data. The results demonstrate that research data sharing is not a rare practice among information scientists. Due to problems with different information horizons of the sharing and the reusing researchers, the reusing of data sets is much rarer than the reuse of supplementary materials.
Structure and usage do not explain each other: an analysis of German word-initial clusters
Authors: Wiese Richard , Orzechowska Paula 
Published: August 2023

Abstract
The present study focuses on German word-initial consonant clusters and asks whether feature-based phonotactic preferences correlate with patterns of type and token frequencies in present-day usage. The corpus-based analyses are based on a comprehensive list of such clusters, representing current usage, and on a number of feature-based phonotactic preferences. Correlating the variables by means of a correlation analysis and a regression analysis leads to a number of observations relevant to the general topic of featural-segmental structures versus usage. First, out of eighteen correlations between (raw and logarithmic) type and token frequencies, and preferred feature patterns, only one significant correlation was found. Second, a regression analysis led to similar results: out of thirteen variables tested, only two contribute to logarithmic type and token frequencies. Only a limited set of cluster properties investigated in the present paper constitutes a relevant predictor of frequency measures. The study thus demonstrates, in accordance with other recent evidence, that preferred phonetic/phonological structures and their usage frequency constitute two separate domains for which distributions may not have to coincide.
Luteolin alleviates ulcerative colitis in rats via regulating immune response, oxidative stress, and metabolic profiling
Authors: Li Bolin , Guo Yuxi , Jia Xuemei , Cai Yanru , Zhang Yunfeng , Yang Qian 
Published: August 2023

Abstract
Ulcerative colitis (UC) is an inflammatory bowel disease and associated with metabolic imbalance. Luteolin (LUT) reportedly exhibits anti-inflammatory activity. However, its regulatory effects on metabolites remain indistinct. Here, the effects of LUT on immune response and oxidative stress in UC were determined. Serum metabolomics profiles of UC rats treated with LUT were obtained utilizing liquid chromatography-mass spectrometry. The results revealed that LUT treatment alleviated colon tissue injury, colon shortening, weight loss, and inflammatory response in UC rats. Additionally, the levels of superoxide dismutase and total antioxidant capacity were elevated, but malondialdehyde content was reduced in serum of UC rats, while these changes were abrogated by LUT. Metabolomics analysis unveiled that l-malic acid, creatinine, l-glutamine, and l-lactic acid levels were remarkably decreased, while dimethyl sulfone, 5-methylcytosine, cysteine-S-sulfate, and jasmonic acid levels were notably increased after LUT treatment. Furthermore, differential metabolites primarily participated in d-glutamine and d-glutamate metabolism, glutathione metabolism, and citrate cycle pathways. In summary, these results demonstrated that LUT improved immune response, alleviated oxidative stress, and altered metabolites in UC rats. This study lays the root for further exploring the mechanism of LUT in the treatment of UC.
Intensification of biocatalytic processes by using alternative reaction media
Authors: Delavault André , Ochsenreither Katrin , Syldatk Christoph 
Published: August 2023

Abstract
Performances of biocatalytic processes in industry are often limited by productivity, product concentration and biocatalyst stability. Reasons can be such as unfavourable reaction thermodynamics, low water solubility of the substrates or inhibition caused by high substrate or product concentrations. A way to overcome these limitations and to enhance economic competitiveness of the process can be process intensification (PI) using an alternative reaction medium. Very early in industrial biotransformation processes, it was shown that many interesting target products of organic synthesis are much more soluble and sometimes even more stable in non-conventional reaction media than in buffered aqueous solutions. Moreover, the absence of water is also generally desired to prevent side and degradation reactions as well as microbial contamination, which in turn eliminates the need to work under sterile conditions thereby reducing energy expenditure. In addition, it was also discovered early on that solvents can influence the activity and stability of enzymes quite differently depending on their water affinity and thus if they form rather monophasic or biphasic systems with the latter.
A variation of the class of statisticalγcovers
Authors: Bal Prasenjit , Rakshit Debjani 
Published: August 2023

AbstractIn this article, we introduce s-s-γ\gammacover using the notion of star operator, which is an extension of the previous results on s-γ\gammacovers. We also define s-s-dense set to address the issue that a statistical dense subset of an s-s-γ\gammacover is not an s-s-γ\gammacover. Furthermore, we study some results on s-γ\gammacovers in subspace topology.
Social Representations on Lithuanian Women Leaders in the STEAM Fields: A Critical Discourse Analysis
Authors: Buelvas-Baldiris Tatiana , Rubira-García Rainer , Pocevičienė Rasa 
Published: August 2023

Science, technology, engineering, arts, and mathematics (STEAM) are fields substantially crucial for innovation and development. Nevertheless, the gender gap in these areas is significant also in European countries. Considering the underrepresentation of STEAM women’s leadership, we provide insight into the common characteristics that led Lithuanian women to become referents in their fields. We identify elements of leadership in discursive social representations, professional ideologies, gender identity and role congruency in connection to power structures from a gender perspective within organisations, considering the mediations of the social context. We conducted the research in two phases: an online questionnaire and in-depth interviews. We performed a critical discourse analysis of Lithuanian Women’s testimonies to understand gender social representations. Parenthood highly influences building leadership and choosing STEAM careers, whereas self-efficacy and creativity are essential elements. High co-responsibility at home confirms that family context is vital. In STEAM careers, a male-centric perspective still constrains female leadership. There is still work to be done regarding active politics, programs, and law enforcement to create equity and social justice relationships between men and females, especially in STEAM areas.
Kobiety vs media społecznościowe – jak Internet oddziałuje na ich życie
Authors: Madej Martyna 
Published: August 2023

Cel. Badania, zostały skonstruowane z myślą o kobietach, temu czy i w jaki sposób media społecznościowe oddziałują na ich życie. Celem było uzyskanie odpowiedzi dotyczących tego, jakie grupy wiekowe i jakie osoby najczęściej odczuwają działanie mediów. Ważnym stało się także to, czy istotne i w jaki sposób w codzienności przejawia się działanie Internetu oraz czy i jakie niesie on za sobą konsekwencje dla pewności siebie wśród kobiet.
Metody. Do przeprowadzenia badań stworzono oryginalny formularz ankiety, który został opublikowany w mediach społecznościowych. W badaniu wzięło udział 156 pełnoletnich kobiet, z różnych grup wiekowych. Wyniki badań zostały poddane analizie porównawczej, a poszczególne wyniki zostały porównane przy wykorzystaniu współczynnika korelacji Spearmana.
Wyniki i wnioski. Udało się potwierdzić wszystkie postawione hipotezy oraz uzyskać odpowiedzi na postawione pytania badawcze. Dzięki badaniom stało się możliwe wskazanie sposobów, w jaki media społecznościowe oddziałują na różne typy kobiet. Zgodnie z uzyskanymi wynikami najrzadziej negatywne działanie mediów społecznościowych na swoje życie odczuwają kobiety po 50. roku życia. Ta grupa wiekowa częściej wskazywała, że czuje się pewna siebie oraz wyżej oceniała swój wygląd. Kobieta, która częściej odczuwa negatywne oddziaływanie mediów społecznościowych na swoje życie prezentuje się jako osoba niepewna siebie i nisko oceniająca swój wygląd, przy czym oba te czynniki może nieznacznie pogorszyć długie spędzanie czasu w sieci. Przeciętna kobieta odczuwająca pozytywne działanie mediów społecznościowych częściej była pewna siebie i wyżej oceniała swój wygląd. Ten typ kobiety również wykazał, że dłuższe przeglądanie treści typu beauty może nieznacznie przyczynić się do zachęcenia do samooakceptacji.
A Pszichológiai Alapszükségletek a Munkában Kérdőív pszichometriai mutatóinak és validitásának vizsgálata
Authors: Csordás Georgina , Matuszka Balázs , Sallay Viola , Martos Tamás 
Published: August 2023

Háttér és célkitűzésekAz Öndetermináció Elmélete egyre több munka- és szervezetpszichológiával kapcsolatos pozitív pszichológiai megközelítésű kutatás alapját képezi. Az elmélet szerint a pszichológiai alapszükségletek (autonómia, kompetencia és kapcsolódás) kielégítettsége vitális szerepet tölt be a munkahelyi jóllétben. Az eddigi hazai és nemzetközi kutatások alapján a konstruktumok pozitív összefüggést mutattak a jólléttel, valamint a munkával való elégedettséggel, és alacsonyabb munkahelyelhagyási szándékkal jártak. Jelen kutatás célja a Pszichológiai Alapszükségletek a Munkában Kérdőív magyar nyelvre való adaptálásának közlése, a mérőeszköz pszichometriai mutatóinak feltárása.MódszerA kutatás mintáját magyar munkavállalók adták (N = 681, 66% nő, átlagéletkor = 38,6 év, SD = 11,39 év). Az online kérdőíves adatfelvétel során a Pszichológiai Alapszükségletek a Munkában Kérdőív mellett a Munkával Való Elégedettség Kérdőív, valamint a Munka Értelmessége Kérdőív is szerepelt. A kérdőív faktorstruktúráját megerősítő faktoranalízissel ellenőriztük.EredményekA megerősítő faktoranalízis során a háromdimenziós faktorstruktúra jó illeszkedést mutatott, valamint a kérdőív megbízhatósága és érvényessége is megfelelő volt, pozitív együttjárást találtunk mindhárom pszichológiai alapszükséglet kielégítettsége és a munkával való elégedettség, illetve a munka értelmességének megélése között, valamint negatív együttjárást a munkahelyelhagyás szándékával.KövetkeztetésekA Pszichológiai Alapszükségletek a Munkában Kérdőív a gyakorlatban is jól alkalmazható mérőeszköz, mellyel kvantifikálható az autonómia, a kompetencia és a kapcsolódás alapszükségletének a munkavállaló által megélt kielégítettsége. Kutatásunk megerősíti, hogy ezek a tapasztalatok alapvetőek az optimális munkahelyi működéshez.
Barriers to Antiretroviral Medication Adherence
in People Living with HIV (PLHIV)
at the time of COVID-19 Pandemic
in the Philippines
Authors: Joves Philip John , Matulac Melgar , Pagcatipunan Jr. Rodolfo 
Published: August 2023

I.	Introduction: Adherence to ART reduces morbidity and mortality among PLHIV by suppression of viral replication, restoration and preservation of immune function. However, poor adherence may lead to treatment failure and death. PLHIV have high probability of treatment interruptions due to lockdowns related to COVID-19 protocol. Mortality rate is higher among COVID-19 patients with HIV than those with COVID-19 only. This led to determination of the barriers to antiretroviral medication adherence in PLHIV at the time of COVID-19 pandemic and seek significant association between identified HIV treatment barriers and socio-demographic characteristics.

II.	Methods: A cross-sectional study using online survey questionnaire was distributed via social media. Sample size was computed using Open Epi software. Data was analyzed using Stata software. Categorical variables and quantitative data were summarized using frequencies and percentages, and mean and standard deviation respectively. Chi-square test or Fisher’s exact test, whichever is more appropriate, was used to determine association between socio-demographic characteristics and HIV treatment barriers.

III.	Results: There is a total of 116 respondents, 115 were males, homosexual (59.5%), with mean age of 30.25 years old (SD = 6.22) and majority (53.4%) were from NCR. The most common HIV treatment barriers reported by PLHIV in accessing treatment and care were unavailability of transportation and cost of courier services for ARV delivery (62.1%), location of treatment hubs (52.6%) and financial assistance (37.9%).

IV.	Conclusion: There is significant association between location of treatment hubs and respondents who finished college/graduate studies; checkpoints and crossing borders and: 1. respondents from Northern Luzon, 2. unemployment; financial assistance and: 1. Respondents 18 to 25 years old, 2. unemployment, 3. respondents who finished elementary/high school; psychosocial support and: 1. Respondents from NCR, 2. Respondents 26 to 30 years old;