bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Systematic Review of Glaucoma Diagnosis in Prevalence Studies and Quality of Reporting
Authors: Al-Timimi Zayn , Huang-Lung Jessie , Keay Lisa , Healey Paul , Yang Eleanor , Dunn Hamish 
Published: July 2023

Précis:
This systematic review has revealed that variable definitions of glaucoma continue to be used in prevalence studies, despite the introduction of the International Society of Geographic and Epidemiologic Ophthalmology (ISGEO) criteria.

Purpose:
To systematically review diagnostic criteria and examinations performed in glaucoma prevalence studies over time and determine the quality of reporting. Accurate estimates of glaucoma prevalence are crucial to inform resource allocation. However, diagnosis of glaucoma comprises inherently subjective examinations and the cross-sectional nature of prevalence studies precludes monitoring for progression.

Methods:
A systematic review of PubMed, Embase, Web of Science, and Scopus was performed to examine diagnostic protocols used by glaucoma prevalence studies and evaluate uptake of the ISGEO criteria, introduced in 2002 to standardize glaucoma diagnosis in prevalence studies. Detection bias and compliance with the Strengthening Reporting of Observational Studies in Epidemiology (STROBE) guidelines were evaluated.

Results:
Ten thousand five hundred forty-four articles were identified. After deduplication, 5589 articles were screened, yielding 136 articles pertaining to 123 studies. An absence of data in many countries was identified. Ninety-two percent of studies stated diagnostic criteria, and 62% used the ISGEO criteria since their publication. Weaknesses of the ISGEO criteria were identified. Temporal variations in the performance of various examinations were observed, including heterogeneity in angle assessment. Mean STROBE compliance was 82% (range 59–100%); 72 articles had a low risk of detection bias, 4 had a high risk, and 60 had some concerns.

Conclusion:
Heterogeneous diagnostic definitions persist in glaucoma prevalence studies, despite introduction of the ISGEO criteria. Standardization of criteria remains imperative and the development of new criteria represent a valuable opportunity to achieve this goal. In addition, methods of determining diagnoses are poorly reported, suggesting a need for improvement in study conduct and reporting. Accordingly, we propose the Reporting of quality Of GlaUcoma Epidemiological Studies (ROGUES) Checklist. We have also identified a need for further prevalence studies in regions with limited data and to update Australian angle closure glaucoma prevalence. Design and reporting of future studies can be informed by this review’s insights into diagnostic protocols previously used.
Effectiveness of Tick-borne Encephalitis Vaccines in Children, Latvia, 2018–2020
Authors: Zavadska Dace , Freimane Zane , Karelis Guntis , Ermina Ineta , Harper Lisa R. , Bender Cody , Zhang Pingping , Angulo Frederick J. , Erber Wilhelm , Bormane Antra , Griskevica Aija , Moïsi Jennifer C. , Jodar Luis 
Published: July 2023

Background:
Tick-borne encephalitis (TBE) is an infection by the tick-borne encephalitis virus (TBEV) with symptoms of central nervous system inflammation. TBE is endemic in Latvia and other parts of Europe. TBE vaccination is recommended for children in Latvia. TBE vaccine effectiveness (VE) was estimated in Latvia, a country with high TBE incidence, providing the first VE estimates against a range of TBEV infection outcomes in children 1–15 years-of-age.

Methods:
Rīga Stradinš University conducted nationwide surveillance for suspected TBE cases. Serum and cerebrospinal fluid were ELISA tested for TBEV-specific IgG and IgM antibodies. A fully vaccinated child was an individual who had received the 3-dose primary series and appropriately timed boosters. The proportion of laboratory-confirmed TBE cases fully vaccinated (PCV) was determined from interviews and medical records. The proportion of the general population fully vaccinated (PPV) was determined from national surveys conducted in 2019 and 2020. TBE VE in children 1–15 years-of-age was estimated using the screening method: VE = 1 − [PCV/(1 − PCV)/PPV/(1 − PPV)].

Results:
From 2018 to 2020, surveillance identified 36 TBE cases in children 1–15 years-of-age; all were hospitalized, 5 (13.9%) for >12 days. Of the TBE cases, 94.4% (34/36) were unvaccinated compared with 43.8% of children in the general population. VE against TBE hospitalization in children 1–15 years-of-age was 94.9% (95% confidence interval 63.1–99.3). In 2018–2020, vaccination in children 1–15 years-of-age averted 39 hospitalized TBE cases.

Conclusion:
Pediatric TBE vaccines were highly effective in preventing TBE in children. Increasing TBE vaccine uptake in children is essential to maximize the public health impact of TBE vaccination.
Reconstruction of Large Full-Thickness Lower Eyelid Defects With Remnant Eyelid Rotation, Semicircular Skin and Muscle Flap, and Lateral Tarsoconjunctival Flap
Authors: Camacho Maria Belen , Han Michael M. , Dermarkarian Christopher R. , Tao Jeremiah P. 
Published: July 2023

Purpose:
To describe and assess the results of reconstruction of large, full-thickness defects of the central or medial lower eyelid using a semicircular skin flap, rotation of the remnant lateral eyelid, and a lateral tarsoconjunctival flap.

Methods:
The surgical approach is described, and the authors performed a retrospective chart review of consecutive patients between 2017 and 2023 reconstructed with this technique. Outcomes were assessed for size of eyelid defect, vision, subjective symptoms, facial and palpebral aperture symmetry, eyelid position and closure, corneal examination, surgical complications, and need for subsequent surgical intervention. Postoperative appearance was graded on malposition, distortion, asymmetry, contour deformity, and scarring (MDACS).

Results:
Charts of 45 patients were identified. The average size of the lower eyelid defect was 18 mm (ranging from 12 to 26 mm). Facial and palpebral aperture symmetry were acceptable and all patients had preserved visual acuity and eyelid position and closure. The MDACS cosmetic score was perfect (0) in 15.6% (7/45) of eyelids, good (1–4) in 80.0% (36/45) of eyelids, and mediocre (5–14) in 4.4% (2/45) of eyelids. Second stage reconstruction was not necessary in 32 (71.1%) cases. There were no serious surgical complications, but minor complications included redness of the eyelid margin and pyogenic granulomas.

Conclusions:
Medial rotation of the remnant lower eyelid with a lateral semicircular skin and muscle flap over a lateral tarsoconjunctival flap was very effective in this series. Benefits include scarring within the facial skin tension lines, maintained vision throughout the recovery period, no eyelid retraction, and often single stage reconstruction.
Comparative Different Interventions to Improve Medication Adherence in Patients with Hypertension
Authors: Yuan Wei , Zhang Yu , MA LiHua 
Published: July 2023

Background
Hypertension has become a major public problem. One of every 4 adults has hypertension. Medications are critical in controlling blood pressure, but patient medication adherence is low. Therefore, it is very crucial to promote medication adherence. However, the complexity and variety of interventions cause clinical decision-making difficulties for health managers and patients.

Objective
The aim of this study was to compare the effectiveness of different interventions to improve medication adherence in patients with hypertension.

Methods
We searched PubMed, Cochrane Library, Web of Science, EMBASE, Wan Fang, China National Knowledge Infrastructure, China Science and Technology Journal Database, and China Biology Medicine disc databases for eligible studies. Medication adherence rate and medication adherence difference were assessed as outcomes. Sensitivity analysis and inconsistency detection were performed to evaluate whether the exclusion of high-risk studies affected the validity. The risk of bias was assessed using the risk of bias table in Review Manager 5.4. The surface under the cumulative ranking curve was used to estimate the rankings among different interventions.

Results
Twenty-seven randomized controlled trials were included, and the interventions involved were categorized into 8 different categories. The network meta-analysis showed that the health intervention was the best to promote medication compliance in patients with hypertension.

Conclusions
Health intervention is recommended to improve medication adherence in patients with hypertension.

Clinical Implications
Health managers are recommended to provide health intervention to patients with hypertension to improve their medication adherence. This approach reduces morbidity, mortality, and healthcare costs for patients with cardiovascular disease.
Effectiveness of Meaning-Centered Coaching on the Job of Oncology Nurses on Spiritual Care Competences
Authors: Modderkolk Linda , van Meurs Jacqueline , de Klein Veronique , Engels Yvonne , Wichmann Anne B. 
Published: July 2023

Background
Nurses’ competences in providing spiritual care can increase quality of care for and quality of life of patients with cancer and job satisfaction but are often suboptimal. Training to improve this mostly takes place off-site, although implementation in daily care practice is key.

Objectives
The aims of this study were to implement a meaning-centered coaching on the job intervention and to measure its effects on oncology nurses’ spiritual care competences and job satisfaction, and factors influencing this.

Methods
A participatory action research approach was adopted. Mixed methods were used to assess intervention effects in which nurses of an oncology ward in a Dutch academic hospital participated. Spiritual care competences and job satisfaction were quantitatively measured and complemented with content analysis of qualitative data.

Results
Thirty nurses participated. A significant increase in spiritual care competences was found, particularly regarding communication, personal support, and professionalization. More self-reported awareness of personal experiences in caring for patients, and an increase in mutual communication and involvement around meaning-centered care provision as a team were found. Mediating factors were related to nurses’ attitudes, support structures, and professional relations. No significant impact was found on job satisfaction.

Conclusion
Meaning-centered coaching on the job increased oncology nurses’ spiritual care competences. Nurses developed a more exploratory attitude in their communication with patients—instead of acting based on their own assumptions about what is of meaning.

Implications for Practice
Attention to and improving spiritual care competences should be integrated into existing work structures, and terminology used should match existing understandings and sentiments.
Strategies Used by Outpatient Oncology Nurses to Introduce Early Palliative Care
Authors: Mohammed Shan , Swami Nadia , Pope Ashley , Rodin Gary , Zimmermann Camilla 
Published: July 2023

Background
Although early palliative care is linked to improved health-related quality of life, satisfaction with care, and symptom management, the clinical strategies that nurses use to actively initiate this care are unknown.

Objectives
The aims of this study were to conceptualize the clinical strategies that outpatient oncology nurses use to introduce early palliative care and to determine how these strategies align with the framework of practice.

Methods
A constructivist-informed grounded theory study was conducted in a tertiary cancer care center in Toronto, Canada. Twenty nurses (6 staff nurses, 10 nurse practitioners, and 4 advanced practice nurses) from multiple outpatient oncology clinics (ie, breast, pancreatic, hematology) completed semistructured interviews. Analysis occurred concurrently with data collection and used constant comparison until theoretical saturation was reached.

Results
The overarching core category, pulling it all together, outlines the strategies used by oncology nurses to support timely palliative care referral, drawing on the coordinating, collaborating, relational, and advocacy dimensions of practice. The core category incorporated 3 subcategories: (1) catalyzing and facilitating synergy among disciplines and settings, (2) promoting and considering palliative care within patients’ personal narratives, and (3) widening the focus from disease-focused treatment to living well with cancer.

Conclusion
Outpatient oncology nurses enact unique clinical strategies, which are aligned with the nursing framework and reflected multiple dimensions of practice, to introduce early palliative care.

Implications for Practice
Our findings have clinical, educational, and policy implications for fostering the conditions in which nurses are supported to maximize their full potential in the introduction of early palliative care.
Association between skeletal muscle mass index and falls in patients with functional impairment
Authors: Arai Hideki , Nozoe Masafumi , Kamiya Kuniyasu , Matsumoto Satoru , Morimoto Takeshi 
Published: July 2023

Abstract

Objective
This study aimed to assess the association between skeletal muscle mass index and falls in patients with functional impairment.

Design
This retrospective cohort study was implemented at a convalescent rehabilitation ward. Patients with no measurement of skeletal muscle mass index and bed-ridden patients were excluded from this study. Patients were dichotomized into the low skeletal muscle mass index group and the high skeletal muscle mass index group. The occurrence of fall was assessed according to skeletal muscle mass index groups.

Results
Out of the 327 included patients, 231 (71%) were assigned to the low skeletal muscle mass index group. In total, 66 patients (20%) experienced at least one fall, and a total of 102 falls occurred. The incidence of falls for the low skeletal muscle mass index group was not significantly greater than that for the high skeletal muscle mass index group (4.9 per 1000 patient-days vs. 4.5 per 1000 patient-days, P = 0.9). Low skeletal muscle mass index was not significantly associated with one or more incidents of falls (OR (95% CIs) = 0.6 (0.3–1.17)).

Conclusion
This study found that skeletal muscle mass index was not significantly associated with falls in patients undergoing convalescent rehabilitation.
PHYSICAL ACTIVITY AND ASSOCIATED FACTORS AMONG PATIENTS ATTENDING HYPERTENSION CLINICS IN MBARARA CITY, SOUTHWESTERN UGANDA
Authors: Night Atwongyeire , Maria Ssewanyana Anna , Racheal Namukwaya , Edward Mutesasira , Fred JJunju , Amon Nuwahereza , Damascene Niyonsenga Jean , Whitehouse Zillah , Herman Kazibwe , Wilfred Arubaku 
Published: July 2023

AbstractBackgroundPhysical activity has been shown to prevent mortality and morbidity among people with hypertension. Hypertension has been identified to affect about 33% of the adult population across the globe and 26.4% in Uganda. An increase in hypertension and its adverse outcomes have been observed and reported in Southwestern Uganda. This may be due to physical inactivity. However, there is limited evidence demonstrating physical activity among patients with hypertension within Southwestern Uganda. The current study investigated the extent of physical activity and associated factors among patients attending hypertension clinics in Mbarara City, Southwestern Uganda.ObjectiveTo investigate the extent of physical activity and associated factors among patients attending hypertension clinics in Mbarara City, Southwestern Uganda.MethodsA descriptive, quantitative cross-sectional study was conducted. Participants’ data was obtained using a structured researcher-administered questionnaire consisting of the International Physical Activity Questionnaire (IPAQ) long form, Motivation for Physical Activity Questionnaire (RM4-FM) and the Barrier to Being Active Quiz (BBAQ). Frequency distribution tables, Fischer’s exact test and multivariate logistic regression were used to describe data and establish associations during data analysis. A p-value less than 0.05 with 95% confidence interval was considered to be statistically significant.ResultsLess than half of the participants (45.39%) were found to be physically active. Level of education, having heard of physical activity, place of residence, sedentary behaviour and social influence were associated with physical activity with the Fischer’s exact test (p-value<0.05). On multivariate adjustment, only level of education (aOR=1.374; CI=1.055-1.790; p-value=0.018) and sedentary behaviour (aOR=0.276; CI=0.126-0.606; p-value=0.001) remained significant factors associated with physical activity. Majority of those who were active reported to be autonomously motivated. Most reported barriers were lack of skill, social influence and lack of willpower.ConclusionMore than half of the patients with hypertension were physically inactive and almost half were inactive and sedentary. This is a double disaster especially for patients with hypertension; therefore, emphasis should be put on educating the public about the benefits of physical activity and availing a variety of physical activity options that engage all demographic groups.
Membrane Computing Simulation of Sexually Transmitted Bacterial Infections in Hotspots of Individuals with Various Risk Behaviors
Authors: Campos Marcelino , Galán Juan Carlos , Rodríguez-Dominguez Mario , Sempere José M. , Llorens Carlos , Baquero Fernando 
Published: July 2023

AbstractThe epidemiology of sexually transmitted infections (STIs) is complex due to the coexistence of various pathogens, the variety of transmission modes derived from sexual orientations and behaviors at different ages and genders, and sexual contact hotspots resulting in network transmission. There is also a growing proportion of recreational drug users engaged in high-risk sexual activities, as well as pharmacological self-protection routines fostering non-condom practices. The frequency of asymptomatic patients makes it difficult to develop a comprehensive approach to STI epidemiology. Modeling approaches are required to deal with such complexity. Membrane computing is a natural computing methodology for virtual reproduction of epidemics under the influence of deterministic and stochastic events with an unprecedented level of granularity. The application of the LOIMOS program to STI epidemiology illustrates the possibility of using it to shape appropriate interventions. Under the conditions of our basic landscape, including sexual hotspots of individuals with various risk behaviors, an increase in condom use reduces STIs in a larger proportion of heterosexuals than in same-gender sexual contacts and is much more efficient for reducingN. gonorrhoeaethanChlamydiaand lymphogranuloma venereum infections. Amelioration from diagnostic STI screening could be instrumental in reducingN. gonorrhoeaeinfections, particularly in men having sex with men (MSM), andC. trachomatisinfections in the heterosexual population; however, screening was less effective in decreasing lymphogranuloma venereum infections in MSM. The influence of STI epidemiology of sexual contacts between different age groups (<35 and ≥35 years) and in bisexual populations were also submitted for simulation.ImportanceThe epidemiology of sexually transmitted infections (STIs) is complex and significantly influences sexual and reproductive health worldwide. Gender, age, sexual orientation, sexual behavior (including recreational drug use and physical and pharmacological protection practices), the structure of sexual contact networks, and the limited application or efficiency of diagnostic screening procedures creates variable landscapes in different countries. Modeling techniques are required to deal with such complexity. We propose the use of a simulation technology based on membrane computing, mimickingin silicoSTI epidemics under various local conditions with an unprecedented level of detail. This approach allows us to evaluate the relative weight of the various epidemic drivers in various populations at risk and the possible outcomes of interventions in particular epidemiological landscapes.
Comparative Analysis of Whole Transcriptome Single-Cell Sequencing Technologies in Complex Tissues
Authors: Salcher Stefan , Heidegger Isabel , Untergasser Gerold , Fotakis Georgios , Scheiber Alexandra , Martowicz Agnieszka , Noureen Asma , Krogsdam Anne , Schatz Christoph , Schäfer Georg , Trajanoski Zlatko , Wolf Dominik , Sopper Sieghart , Pircher Andreas 
Published: July 2023

ABSTRACTThe development of single-cell omics tools has enabled scientists to study the tumor microenvironment (TME) in unprecedented detail. However, each of the different techniques may have its unique strengths and limitations. Here we directly compared two commercially available high-throughput single-cell RNA sequencing (scRNA-seq) technologies - droplet-based 10X Chromiumvs.microwell-based BD Rhapsody - using paired samples from patients with localized prostate cancer (PCa) undergoing a radical prostatectomy.Although high technical consistency was observed in unraveling the whole transcriptome, the relative abundance of cell populations differed. Cells with low-mRNA content such as T cells were underrepresented in the droplet-based system, at least partly due to lower RNA capture rates. In contrast, microwell based scRNA-seq recovered less cells of epithelial origin. Moreover, we discovered platform-dependent variabilities in mRNA quantification and cell-type marker annotation. Overall, our study provides important information for selection of the appropriate scRNA-seq platform and for the interpretation of published results.SYNOPSISComparison of scRNA-seq protocols uncovers disparities in RNA-to-library conversionMicrowell-based scRNA-seq technology excels in capturing low-mRNA content cellsBiased transcriptomes due to gene specific RNA detection efficacies by both platformsThe study guides in informed scRNA-seq platform selection and data interpretation
Phosphorylation-dependent interactions of VAPB and ELYS contribute to the temporal progression of mitosis
Authors: James Christina , Möller Ulrike , König Sabine , Urlaub Henning , Kehlenbach Ralph H. 
Published: July 2023

AbstractELYS is a nucleoporin that localizes to the nuclear side of the nuclear envelope in interphase cells. In mitosis, it serves as an assembly platform that interacts with chromatin and then with nucleoporin subcomplexes to initiate the formation of novel nuclear pore complexes. Here we describe the interaction of ELYS with the membrane protein VAPB. In mitosis, ELYS becomes phosphorylated at many sites, including a predicted FFAT (two phenylalanines in an acidic tract) motif, which is shown to mediate interaction with the MSP (major sperm protein)-domain of VAPB. Phosphorylation-dependent binding of VAPB to ELYS is demonstrated by peptide binding assays and co-immunoprecipitation experiments. In anaphase, the two proteins co-localize to the non-core region of the newly forming nuclear envelope. Depletion of VAPB resulted in prolonged mitosis and slow progression from meta-to anaphase and also to chromosome segregation defects. Together, our results suggest an active role of VAPB in recruiting membrane fragments to chromatin and in the biogenesis of a novel nuclear envelope during mitosis.
WITHDRAWN: Neuron-dependent tuft cell expansion initiates sinonasal allergic Type 2 inflammation
Authors: Ortiz-Carpena Jorge F. , Inclan-Rico Juan M. , Pastore Christopher F. , Hung Li-Yin , Wilkerson William B. , Weiner Molly B. , Lin Cailu , Gentile Maria Elena , Cohen Noam A. , Saboor Ishmail Abdus , Vaughan Andrew E. , Rossi Heather L. , Herbert De’Broski R. 
Published: July 2023

Withdrawal StatementThe authors have withdrawn this manuscript owing to inaccuracies in the calculation of tuft cell numbers and errors in the selection of immunofluorescence images used to support our claims. Therefore, the authors do not wish this work to be cited as reference for the project. If you have any questions, please contact the corresponding author.