bluuebunny/crossref_metadata_2025_split huggingface dataset:
The arts and culture: burden or contributor for exiting the crisis? A French perspective.
Authors: Tobelem Jean-Michel 
Published: June 2023

With the financial crisis, followed by the economic and social crisis which spread from the United States to Europe, the trend towards less and less public spending being allocated to culture has accelerated. At the same time, however, public officials affirm that the arts, culture and, more broadly, the creative industries, constitute one of the most reliable means available to contemporary developed societies to overcome the crisis.How can such a paradox be understood? Are public authorities schizophrenic? Is there a contradiction in the definition and the implementation of public policies? Conversely, can one hypothesize that public action has a logical underpinning? What would be its basis?The answer may be identified on two levels: on the one hand, there is an increasing instrumentalisation of artistic and cultural activities, which are used for ends which are at least partly foreign to them (in particular, to economic and diplomatic ends). On the other hand, a reorientation of public policies concerning the creative and cultural industries is occurring. It would seem that it is in this sense that the engagement of a growing number of CEOs and leaders in favor of the cultural industries may be understood.This policy choice, even if it appears to offer certain strategic opportunities to the artistic and cultural sector, seems nevertheless to involve serious risks for cultural creation, artistic experimentation and “scientific” activities undertaken by museums. Furthermore, it risks accentuating the trend of concentrating public and private funds on the most prominent museums and historical sites, thereby threatening to accentuate the implementation of a two-tier system in France, as well as in the UK.
Pancreatic Cancer Progression Is Regulated by IPO7/p53/LncRNA MALAT1/MiR-129-5p Positive Feedback Loop
Authors: Xu Jin , Xu Weixue , Xuan Yang , Liu Zhen , Sun Qinyun , Lan Cheng 
Published: June 2023

Background: Pancreatic cancer is a malignancy with poor prognosis. Importin 7 (IPO7) is a soluble nuclear transport factor, which has been linked to the pathogenesis of several human diseases. However, its role and underlying mechanism in pancreatic cancer are still obscure.Methods: Immunohistochemical staining and quantitative real-time polymerase chain reaction (qPCR) were performed to determine IPO7 expression in pancreatic cancer tissues and adjacent tissues. Western blot was used to measure IPO7 expression at the protein level in cell lines. Cell Counting Kit-8 (CCK-8), 5-bromo-2′-deoxyuridine (BrdU), flow cytometry, and Transwell assays were employed to explore the biological functions of IPO7. Subcutaneous xenograft transplanted tumor model and caudal vein injection model in mice were also established to validate the oncogenic role of IPO7. Western blot and qPCR were utilized to detect the regulatory function of IPO7 on p53 and metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), respectively. Interaction between MALAT1 and miR-129-5p and interaction between miR-129-5p and IPO7 were verified by bioinformatics prediction, qPCR, dual-luciferase reporter gene experiment, RNA immunoprecipitation (RIP), and pull-down assay.Results: Upregulation of IPO7 in pancreatic cancer tissues was associated with adverse prognosis of the patients with pancreatic cancer. Knocking down IPO7 remarkably suppressed cancer cell proliferation and metastasis, while it promoted apoptosis. Overexpression of IPO7 facilitated the malignant phenotypes of pancreatic cancer cells. Mechanistically, IPO7 could repress the expression of p53 and induce the expression of MALAT1 but reduce miR-129-5p expression. Furthermore, miR-129-5p was identified as a posttranscriptional regulator for IPO7, and its inhibition led to IPO7 overexpression in pancreatic cancer cells.Conclusion: IPO7 is a novel oncogene for pancreatic cancer, and IPO7/p53/MALAT1/miR-129-5p positive feedback loop facilitates the progression of this deadly disease.
Immune mechanisms in vulvodynia: key roles for mast cells and fibroblasts
Authors: Tonc Elena , Omwanda Gloriah K. , Tovar Kevin Arnold , Golden Xiu Mei Emma , Chatterjea Devavani 
Published: June 2023

Vulvodynia is a debilitating condition characterized by painful sensitivity to touch and pressure in the vestibular tissue surrounding the vaginal opening. It is often a “diagnosis of exclusion” of idiopathic pain made in the absence of visible inflammation or injury. However, the association between increased vulvodynia risk and a history of yeast infections and skin allergies has led researchers to explore whether immune mechanisms of dysregulated inflammation might underlie the pathophysiology of this chronic pain condition. Here we synthesize epidemiological investigations, clinical biopsies and primary cell culture studies, and mechanistic insights from several pre-clinical models of vulvar pain. Taken together, these findings suggest that altered inflammatory responses of tissue fibroblasts, and other immune changes in the genital tissues, potentially driven by the accumulation of mast cells may be key to the development of chronic vulvar pain. The association of increased numbers and function of mast cells with a wide variety of chronic pain conditions lends credence to their involvement in vulvodynia pathology and underscores their potential as an immune biomarker for chronic pain. Alongside mast cells, neutrophils, macrophages, and numerous inflammatory cytokines and mediators are associated with chronic pain suggesting immune-targeted approaches including the therapeutic administration of endogenous anti-inflammatory compounds could provide much needed new ways to treat, manage, and control the growing global pandemic of chronic pain.
Extracorporeal membrane oxygenation for acute pulmonary embolism after postoperative craniocerebral trauma: a case report
Authors: Liao Xiaozu , Chen Xiaojuan , Zhong Shi , Wen Junlin , Li Binfei 
Published: June 2023

IntroductionMassive pulmonary embolism (PE) is a life-threatening complication of major surgery with a mortality rate of up to 50%. Extracorporeal membrane oxygenation (ECMO) is primarily used for respiratory and circulatory support. Venoarterial extracorporeal membrane oxygenation (VA-ECMO) is used to stabilize patients with acute massive PE. Acute brain injury, vascular disease, and immunosuppression are contraindications to ECMO, as stated in the 2021 Extracorporeal Life Support Organization guidelines.Case summaryWe report a case of a patient with craniocerebral trauma whose postoperative course was complicated by massive PE and subsequent cardiac arrest that required urgent VA-ECMO, followed by anticoagulation with heparin. The patient showed hemodynamic improvement and was discharged 68 days after hospitalization.DiscussionECMO has gradually been accepted for patients with craniocerebral injuries. The safety and effectiveness of ECMO in patients with craniocerebral injury, along with the optimal duration of ECMO and anticoagulation strategies, require further study.
Digital vs. physical ear-nose-and-throat specialist assessment screening for complicated hearing loss and serious ear disorders in hearing-impaired adults prior to hearing aid treatment: a randomized controlled trial
Authors: Siggaard Lene Dahl , Jacobsen Henrik , Hougaard Dan Dupont , Høgsbro Morten 
Published: June 2023

IntroductionThis study introduces a digital assessment tool for asynchronous and remote ear-nose-and-throat (ENT) specialist assessment screening for complicated hearing loss and serious ear disorders in hearing-impaired adults prior to hearing aid (HA) treatment. The +60 population will nearly double from 12% to 22% between 2015 and 2050 increasing the incidence of age-induced hearing impairment and the need for hearing rehabilitation. If un-diagnosed, age-related hearing loss negatively affects quality of life by accelerating social distancing and early retirement as well as increasing risk of anxiety, depression, and dementia. Therefore, innovative measures are essential to provide timely diagnostics and treatment.MethodsA total of 751 hearing-impaired adults without previous HA usage or experience were randomly assigned to digital or physical ENT specialist assessment screening prior to HA treatment initiation in 20 public and private hearing rehabilitation and ENT specialist clinics in the North Denmark Region. A total of 501 test group participants were assigned to digital assessment screening and 250 control group participants to physical assessment screening prior to HA treatment.ResultsIn all, 658 (88%) participants completed the trial and were eligible for analysis. Digital screening sensitivity (0.85, 95% confidence interval (CI) 0.71–0.94) was significantly higher than physical screening sensitivity (0.2, 95% CI: 0.03–0.56). Screening specificity was high for both assessment methods.DiscussionIn a setting where hearing-impaired adults were assessed for HA treatment, digital ENT specialist assessment screening did not compromise patient safety or increase the risk of misdiagnosis in patients with complicated hearing loss and/or serious ear disorders when compared to physical ENT specialist assessment screening.Clinical Trial registrationhttps://clinicaltrials.gov/ct2/show/NCT05154539, identifier: NCT05154539.
Distribution of boulders in coastal waters of Western Pomerania, German Baltic Sea
Authors: Feldens Agata , Marx Denise , Herbst Anne , Darr Alexander , Papenmeier Svenja , Hinz Matthias , Zettler Michael L. , Feldens Peter 
Published: June 2023

This study contributes to a better understanding of geogenic reef distribution in the southern Baltic Sea and highlights the implications of survey-related factors on automated boulder classification when utilizing data from multiple surveys. The distribution of hard grounds and reefs is needed as a baseline for geological and biological studies, but also for offshore construction, navigation and coastal management. In this study we provide maps of the distribution of geogenic reefs for about 750 km2 in the southern Baltic Sea, at the sites Wismar Bay, Darss Sill and Plantagenet Ground. The maps are based on full-coverage backscatter surveys with different side scan sonar and multibeam echo sounder systems. The distribution and number of boulders in the backscatter maps was determined using a convolutional neural network combined with quality control by human experts. The extent of the geogenic reefs was calculated on the basis of the number of boulders in 50 m x 50 m grid cells. We compare the results with previous reef maps based on point sampling, which show reefs of either biogenic or geogenic origin. According to the earlier maps, 11% of the Plantagenet Ground seabed was classified as reef habitat type. This is similar to the result of our study (12%), although we only considered reefs of geogenic origin. In the Darss Sill, geogenic reefs are larger in this study than in previous maps (30% versus 23%). In both regions, the spatial distribution of reefs differs significantly between old and new maps. For Wismar Bay, previous maps classify 3% of the seafloor as habitat type reef, whereas this study classifies 35% as geogenic reef. The use of automated classification during seafloor mapping allowed large areas to be interpreted in a few days. It also provided more information on the distribution of boulders within the geogenic reef. However, the boulder distribution maps show the negative effects of survey geometry, frequency and environmental conditions on automated boulder classification when data from different surveys are combined.
Reproductive outcomes and risk factors of women with septate uterus after hysteroscopic metroplasty
Authors: Chang Yanan , Shen Minghong , Wang Sha , Guo Zhengchen , Duan Hua 
Published: June 2023

BackgroundHysteroscopic metroplasty of the uterine septum has been the standard treatment strategy to improve reproductive outcomes, but there are still controversies about the appropriateness of metroplasty. In addition, there have been few studies of the factors related to reproductive outcomes of women after surgery. The study aimed to evaluate the reproductive outcomes and the associated risk factors that influence reproductive outcomes after hysteroscopic metroplasty of women with septate uterus and the desire to conceive.MethodsThis study was an observational study. Cases were screened by searching electronic patient files, and demographic factors were collected. We conducted telephone follow-ups to collect the postoperative reproductive outcomes. The primary outcome of this study was live birth, and secondary outcomes were ongoing pregnancy, clinical pregnancy, early miscarriage, and preterm birth. Demographic variables included patients’ age, body mass index (BMI), the type of septum, infertility and miscarriage history, and complications including intrauterine adhesions, endometrial polyps, endometriosis, and adenomyosis were collected to perform univariate and multivariate analyses to predict the risk factors of reproductive outcomes after surgery treatment.ResultsIn total, 348 women were evaluated and followed up. There were 95 cases (27.3%, 95/348) with combined infertility, 195 cases (56.0%, 195/348) with miscarriage history, and cases combined with intrauterine adhesions, endometrial polyps, endometriosis, and adenomyosis were 107 (30.7%, 107/348), 53 (15.2%, 53/348), 28 (8.0%, 28/348), and 5 (1.4%), respectively. Following surgery, the live birth rate and clinical pregnancy rate were significantly higher than prior to surgery (84.6% vs 3.7%, p= 0.000; and 78.2% vs 69.5%, p= 0.01, respectively), early miscarriage rate and preterm delivery rate were significantly lower (8.8% vs 80.6%, p= 0.000; and 7.0% vs 66.7%, p=0.000, respectively). After adjusting for body mass index, miscarriage history, and complications, multivariable logistic regression analysis revealed age ≥ 35 years and primary infertility as independent factors that affected postoperative clinical pregnancy (OR 4.025, 95% CI 2.063–7.851, p= 0.000; and OR 3.603, 95% CI 1.903–6.820, p= 0.000; respectively) and ongoing pregnancy (OR 3.420, 95% CI 1.812–6.455, p= 0.000; and OR 2.586, 95% CI 1.419–4.712, p= 0.002; respectively).ConclusionsHysteroscopic metroplasty could lead to improved reproductive outcomes of women with septate uterus. Both age and primary infertility were independent factors for postoperative reproductive outcomes.Trial registrationChi ECRCT20210343
Adult non-urethral complications after hypospadias repair in childhood: presentation, treatment and outcomes
Authors: Stojanovic Borko , Bizic Marta , Bencic Marko , Djordjevic Miroslav L. 
Published: June 2023

PurposeThis study aimed to evaluate a group of adult patients with non-urethral complications after hypospadias repair in childhood, their surgical treatment, and outcomes.Materials and methodsWe analyzed 97 patients, mean age 22.5 years, who were treated in our center between January 2009 and December 2020, for non-urethral complications after previous hypospadias repair in childhood. Non-urethral complications were defined as glans deformity, residual curvature and trapped penis due to insufficient penile skin. A radical surgical approach was used to correct all deformities, in a one-stage or a two-stage procedure. A successful outcome was defined as a straight penis with good length, anatomically regular glans, and cosmetically acceptable appearance, without need for additional surgeries. Sexual function was evaluated using International Index of Erectile Function.ResultsMean follow-up was 75 months (ranged from 24 to 168 months). One-stage and two-stage repair were performed in 85.5% and 14.5% of cases, respectively. A higher success rate was noted after one-stage repair (94% compared to 86%). Complications included four cases of penile curvature with late onset, one case of glans dehiscence and partial skin necrosis. Erectile dysfunction was determined in 24% of patients.DiscussionNon-urethral complications may occur many years after primary hypospadias repair, with a strong impact on the quality of life. Treatment is individualized and usually involves a radical surgical approach to correct all associated deformities and to achieve successful cosmetic and psychosexual outcomes.
Modeling urban tree growth as a part of the green infrastructure to estimate ecosystem services in urban planning
Authors: Fauk Tino , Schneider Petra 
Published: June 2023

Motivation: Planting urban trees is important for urban development. Foliage reflects, scatters, and absorbs incoming shortwave solar radiation, thus reducing the energy flow to the underlying surface, including streets, houses, and humans. Shaded areas, with primarily anthropogenic substrates, are not as heated as nonshaded areas. Subsequently, temperature, radiation and its influence on morbidity of fauna and flora are comparatively lower in these areas.Materials and Methods: Statistical methods were applied to assess the allometric functions of urban trees. The analyzed data were obtained from the tree cadaster of Magdeburg City, Germany, which contains information from 1936 to 2021. As of June 2022, the tree cadaster contained 89,766 trees. The tree species Acer campestre, Acer platanoides, Malus spp., and Quercus robur were subjected to investigation. Nine temperature optimum (TO)/precipitation optimum (PO) scenarios were considered, and their effects on the allometric relationships on the tree species were determined, respectively: 1. TO 17–19°C/PO 450–550 mm, 2. TO 19–21°C/PO 450–550 mm, 3. TO 21–23°C/PO 450–550 mm., 4. TO 17–19°C/PO 550–650 mm, 5. TO 19–21°C/PO 550–650 mm, 6. TO 21–23°C/PO 550–650 mm, 7. TO 17–19°C/PO 650–750 mm, 8. TO 19–21°C/PO 650–750 mm, 9. TO 21–23°C/PO 650–750 mm.Results and Discussion: In six of nine scenarios, a significant correlation was evident for temperature. Water uptake was found to be significant in scenario 6. No significant correlation for competition and breast head diameter growth could be determined in any scenario. Five of the nine scenarios were significantly comparable. While competition was evident as conditionally non-significant (p-value = 0.069 &amp; 0.058), for the elevation forecast in scenarios 3 &amp; 6 only, dependence was evident in all other scenarios. Regarding the crown diameter, temperature was significant in 3 of 9 scenarios. No significant relationship was found for water uptake and competition.Conclusions: No clear abiotic optimum could be identified. Thus, a continuous adjustment of the parameters is necessary to refine the growth functions. Moreover, the growth function adaptation according to the different age phases of trees might be considered on the long term.
Who is publishing in ecology and evolution? the underrepresentation of women and the Global South
Authors: Hughes Alice C. , Than Kay Zin , Tanalgo Krizler C. , Agung Ade Prasetyo , Alexander Tendu , Kane Yakhouba , Bhadra Sreetama , Chornelia Ada , Sritongchuay Tuanjit , Simla Pattraporn , Chen Yanhua , Chen Xing , Uddin Nasir , Khatri Pratibha , Karlsson Catharina 
Published: June 2023

Introduction: Most global biodiversity is in developing economies. Decades of capacity building should have built sufficient in-country capacity to develop biodiversity baselines; yet has effort provided the expertise to build these baselines?Methods: Grants and access to research opportunities are often linked to success in publishing, with the H-index providing the main metric of academic success. Recent compilations of “Top Researchers in Ecology and Evolution” included 5,419 researchers, but where these researchers are and how representative they are has not been well studied. We explored the global distribution of “Top Researchers in Ecology and Evolution” and explored the representation of Women, non-Caucasians, and non-Caucasian women, as well as the representation of “local” top researchers in different regions.Results: Over half Top Researchers in Ecology and Evolution are from just three countries (United States, United Kingdom, and Australia), and 83% come from 12 higher-income countries. Even in lower-income economies the majority of the few “high impact” researchers are originally from higher-income economies. Only China had a high proportion of their high-impact non-Caucasian researchers, with the majority of researchers coming from that region. Women were also underrepresented across the globe, only three countries had more than 20% of top-performing ecologists being female.Discussion: Ultimately, despite decades of capacity building, we are still failing to build in-country capacity for research or to provide sufficient support for female ecologists to publish and lead the field. Here we discuss why these issues persist, and how we might improve representation and access to opportunity and support for all groups, and provide the analysis needed to provide solutions to global challenges in biodiversity conservation, which require diverse representation to develop effective, and nuanced solutions.
Access to provisioning services by local communities from Mpanga central forest reserve in central Uganda
Authors: Gumoshabe Memory , Anywar Godwin , Tugume Patience 
Published: June 2023

IntroductionForest resources are an important source of products on which rural communities depend for survival. Mpanga Central Forest Reserve (CFR) is a valuable resource to adjacent communities through provision of different goods and serves for subsistence and income generation. It also serves as an important eco-tourist site. However, there is scanty information regarding the products obtained from Mpanga CFR and their contribution to livelihoods of adjacent communities.MethodsThe study explored the provisioning services obtained from the CFR, assessed the contribution of the CFR to the surrounding communities and explored the challenges faced while obtaining these services from the forest reserve. Provisioning services are the material benefits supplied by the ecosystem. A total of 118 respondents were randomly selected from 11 villages in Kamengo sub-county Mpigi District and interviewed using semi-structured questionnaires.Results and discussionThe residents obtained wild foods, medicinal herbs, fuelwood, construction and carving materials. Most of the respondents used obtained products for subsistence (51%) while the rest sold them. Regression analysis revealed that 76.5% of the variability in cash income from the CFR is significantly explained by age of respondents, period of stay and education level. Increase in age and educational level of respondents reduced ability to obtain cash income from the forest by (β = −0.19) and (β = −0.625), respectively but increase in period of stay acted in the reverse (β = 0.22). Despite the importance of provisioning services in improving the livelihood of communities adjacent the forest, some challenges in accessing the forest were reported. The quantities of some extracted species had declined over a 5-year period resulting in reduction of household income. This negatively impacts on the livelihoods of the young and uneducated that depend on forest activities for income generation. It is pertinent that alternative livelihood options are sought to address this trend. Also, forest management strategies should provide a win-win situation to forest managers and communities adjacent to the forest. This will not only preserve the forest resource but will also ensure a sustainable livelihood to forest dependent communities.