bluuebunny/crossref_metadata_2025_split huggingface dataset:
Altered expression of synaptic proteins and adhesion molecules in the hippocampus and cortex following the onset of diabetes in nonobese diabetic mice
Authors: Yokokawa Takumi , Kido Kohei , Sato Koji , Hayashi Tatsuya , Fujita Satoshi 
Published: April 2023

AbstractMounting evidence links Type 1 diabetes (T1D) with cognitive dysfunction, psychiatric disorders, and synaptic alterations; however, the underlying mechanism remains unclear. Numerous synaptic proteins and synaptic adhesion molecules (SAMs) that orchestrate synaptic formation, restructuring, and elimination are essential for proper brain function. Currently, it is unclear whether the pathogenesis of T1D is related to the expression of synaptic proteins and SAMs. Here, we investigated whether T1D mice exhibited altered synaptic protein and SAM expression in the hippocampus and cortex. We discovered that T1D mice exhibited partially decreased levels of excitatory and inhibitory synapse proteins and SAMs, such as neurexins, neuroligins, and synaptic cell adhesion molecules. We also found that compared to control mice, T1D mice showed a marginal decrease in body weight and a significant increase in plasma glycoalbumin levels (a hyperglycemia marker). These results provide novel molecular‐level insights into synaptic dysfunction in mice with T1D.
Sex differences in body fluid composition in humans with obstructive sleep apnea before and after CPAP therapy
Authors: Nicholl David D. M. , Hanly Patrick J. , MacRae Jennifer M. , Zalucky Ann A. , Handley George B. , Sola Darlene Y. , Ahmed Sofia B. 
Published: April 2023

AbstractObstructive sleep apnea (OSA) is common in heart and kidney disease, both conditions prone to fluid retention. Nocturnal rostral fluid shift contributes to the pathogenesis of OSA in men more than women, suggesting a potential role for sex differences in body fluid composition in the pathogenesis of OSA, with men having a predisposition to more severe OSA due to an underlying volume expanded state. Continuous positive airway pressure (CPAP) increases intraluminal pressure in the upper airway and mitigates the rostral fluid shift; this, in turn, may prevent fluid redistribution from other parts of the body to the upper airway. We sought to determine the impact of CPAP on sex differences in body fluid composition. Twenty‐nine (10 women, 19 men) incident, sodium replete, otherwise healthy participants who were referred with symptomatic OSA (oxygen desaturation index >15/h) were studied pre‐ and post‐CPAP (>4 h/night × 4 weeks) using bioimpedance analysis. Bioimpedance parameters including fat‐free mass (FFM, %body mass), total body water (TBW, %FFM), extracellular and intracellular water (ECW and ICW, %TBW), and phase angle (°) were measured and evaluated for sex differences before and after CPAP. Pre‐CPAP, despite TBW being similar between sexes (74.6 ± 0.4 vs. 74.3 ± 0.2%FFM, p = 0.14; all values women vs. men), ECW (49.7 ± 0.7 vs. 44.0 ± 0.9%TBW, p < 0.001) was increased, while ICW (49.7 ± 0.5 vs. 55.8 ± 0.9%TBW, p < 0.001) and phase angle (6.7 ± 0.3 vs. 8.0 ± 0.3°, p = 0.005) were reduced in women compared to men. There were no sex differences in response to CPAP (∆TBW –1.0 ± 0.8 vs. 0.7 ± 0.7%FFM, p = 0.14; ∆ECW –0.1 ± 0.8 vs. −0.3 ± 1.0%TBW, p = 0.3; ∆ICW 0.7 ± 0.4 vs. 0.5 ± 1.0%TBW, p = 0.2; ∆Phase Angle 0.2 ± 0.3 vs. 0.0 ± 0.1°, p = 0.7). Women with OSA had baseline parameters favoring volume expansion (increased ECW, reduced phase angle) compared to men. Changes in body fluid composition parameters in response to CPAP did not differ by sex.
Improvement of international reference ionospheric model total electron content maps: a case study using artificial neural network in Egypt
Authors: Mohamed Basma E. , Tawfik Heba S. , Abdelfatah Mohamed A. , El-Fiky Gamal S. 
Published: April 2023

Abstract
An essential ionosphere parameter that can be applied for ionosphere corrections in radio systems is the ionosphere’s total electron content (TEC). TEC is a crucial parameter for ionospheric correction in the Global Navigation Satellite Systems (GNSS) of positioning, navigation, and radio science. This study uses the artificial neural network (ANN) application to improve the International Reference Ionospheric Model (IRI-2016) TEC maps across Egypt. The study period is based on the data that were accessible between 2013 and 2020. The ANN model input parameters are (year, day, hour, latitude, and longitude). The ANN1 and ANN2 estimate TEC values of the enhanced IRI-2020 and IRI-2016 according to the Center for Orbit Determination in Europe (CODE), respectively. ANN3 and ANN4 estimate TEC values of the enhanced IRI-2020 and IRI-2016 regarding IGS stations data analyzed by GNSS Analysis software for the multi-constellation and multi-frequency Precise Positioning (GAMP) model, respectively. The ANN model’s validations were based on the root mean square error (RMSE), correlation coefficient (CC), and T-test. According to the results, the suggested ANN can accurately predict the TEC over Egypt. In comparison to the IRI model, the TEC maps that the ANN models produced are significantly more in accordance with the related CODE and GAMP TEC maps. These results demonstrate that the developed approach can enhance IRI 2016 and IRI-2020s ability to estimate global TEC maps. For the ANN1 model, the mean CC and RMSE are 0.92, and 5.15 TECU for all the global data sets compared by CODE. On the other hand, the CC and RMSE between IRI-2020 and CODE are 0.847 and 7.67 TECU. For the ANN2, the mean CC and RMSE are 0.87, 5.59 TECU compared by CODE, respectively. Although the CC and RMSE between IRI-2016 and CODE are 0.820 and 9.052 TECU respectively. For the ANN3, the CC and RMSE are 0.830 and 4.87 TECU compared with GAMP for all global data, respectively. On the other hand, the CC and RMSE between IRI-2020 and GAMP are 0.644 and 10.41, respectively. For the ANN4 the CC and RMSE are 0.82, and 5.95 TECU compared with GAMP, respectively. Although the CC and RMSE between IRI-2016 and GAMP are 0.665 and 12.347 TECU respectively.
Application of the Ultrasonic Guided Wave Technique Based on PSO-ELM Algorithm in the Rail Fatigue Crack Assessment
Authors: Yu Shangzhi , Zeng Wei , Qi Shikai , Liu Li , Xu Qing , Wu Liangdan 
Published: April 2023

Abstract
Rail safety is very important, and fatigue cracking is one of the important factors affecting rail safety. Therefore, it is an urgent need to develop a safe and effective rail fatigue crack detection technology. Ultrasonic guided wave technology plays an important role in rail detection because of its long propagation distance and small attenuation. In order to realize the quantitative detection of rail fatigue crack, an ultrasonic guided wave technology based on particle swarm optimization–extreme learning machine (PSO-ELM) algorithm for evaluating the rail fatigue crack depth is proposed. The finite element method is used to establish the ultrasonic guided wave model in the rail, and the rail fatigue crack at different depths is simulated. The ultrasonic guided wave selected through the time window function of the excitation signal is used for analysis, and then nine features such as the time domain and the frequency domain of the ultrasonic guided wave are extracted. The PSO-ELM algorithm is used to identify the rail fatigue crack with different depths, and an ultrasonic guided wave-based detection system for the rail fatigue crack is built to verify the relevant theoretical results. The results of finite element simulation and the experiment show that ultrasonic guided wave technology based on PSO-ELM algorithm proposed can quantitatively evaluate the rail fatigue crack with different depths, with an accuracy of more than 99.95 %, which provides an effective method for the rail fatigue crack detection.
Preliminary Investigation into Ultrasound and MRI Presentation of Large-Cell Neuroendocrine Carcinomas of the Uterine Cervix
Authors: Tan Long , Wu Shi-Ji , Qiu Ya , Jie Yue , Zhang Shen , Zhou Shang-Lan , Luo Bao-Ming , Di Na 
Published: April 2023

Abstract

Objective: The aim of this study was to analyze the ultrasound and MRI features of eight patients with cervical large-cell neuroendocrine carcinoma to improve awareness of this disease among sonographers, radiologists, and clinicians.

Methods: Clinical data for eight patients with cervical large-cell neuroendocrine carcinoma confirmed by pathology at Sun Yat-sen Memorial Hospital of Sun Yat-sen University between February 2018 and April 2021 were retrospectively analyzed according to clinical, conventional ultrasound, contrast-enhanced ultrasound, and MRI characteristics.

Results: Conventional ultrasound examination of the cervical large-cell neuroendocrine carcinoma lesions in the eight patients revealed two features: (1) irregular hypoechoic areas in the muscular layer, with slightly hyperechoic inlay streaks, and poorly delineated lesions, and (2) slightly abundant blood flow distribution in the lesions. The contrast-enhanced ultrasound showed a “fast-in and fast-out” mode; after subsidence, a “fence-like” change was observed, and the enhancement range was significantly greater than the range of two-dimensional ultrasound. In MRI, T1WI showed a low signal or isosignal; T2WI showed a high signal; DWI showed a high signal and low ADC value; and most of the enhanced MRI showed inhomogeneous hyperenhancement.

Conclusion: Conventional ultrasound, contrast-enhanced ultrasound and MRI are complementary methods that provide additional imaging information for the diagnosis of cervical large-cell neuroendocrine carcinoma.
Purified Immunoglobulin F(ab′)2 Protects Mice and Rhesus Monkeys against Lethal Ricin Intoxication
Authors: Tian Jingjing , Li Cong , Shi Bochang , Han Hui , Liu Yuan , Tan Lingyun , Wang Keyu , Yan Fang , He Wei , Li Bo , Zheng Naxin , Li Huabin , Li Xinyu , Tian Chongyu , Zheng Yuanqiang , Zhao Zhongpeng , Fan Ruiwen 
Published: April 2023

Objective:
Ricin is a highly toxic ribosome-inactivating lectin derived from castor beans. To date, no antidote is available to treat ricin-poisoned patients, and the development of a safe and effective antidote is urgently needed.

Methods:
First, ricin was prepared and used to construct a mouse model and a rhesus monkey model of ricin intoxication. Second, pepsin-digested F(ab′)2 fragments of serum IgG from horses injected with Freund’s-adjuvanted purified ricin were prepared. Third, the protective efficacy was evaluated in mouse and rhesus monkey models of lethal ricin intoxication.

Results:
The purity quotient of the prepared ricin and F(ab′)2 fragments exceeded 90% and 85% in the mouse and monkey models, respectively. The LD50 of ricin in mice and rhesus monkeys was 2.7 and 9 μg/kg, respectively. A quantity of 6.25 and 1.85 mg/kg F(ab′)2 was sufficient to treat lethal ricin intoxication in the mice and rhesus monkeys, respectively. Finally, the effect of this therapeutic antibody on peripheral blood immune cells was examined by analysis of peripheral blood immune cells through single cell sequencing. The underlying mechanism was found to involve restraining neutrophil activation, proliferation, and differentiation.

Conclusion:
Purified F(ab′)2 fragments administered with needle-free devices fully protect mice and rhesus monkeys against lethal doses of ricin intoxication.
Un’analisi diacronica corpus-based dei soggetti clitici di terza persona singolare in fiorentino.
Authors: Ferrari Lúcia de Almeida , Raso Tommaso 
Published: April 2023

In questo contributo verrà presentata un’analisi diacronica corpus-based dei pronomi clitici soggetto di terza persona singolare gl’, l’, la, e nel vernacolo fiorentino. Obiettivo del lavoro è verificare la questione della supposta perdita dei clitici soggetto in fiorentino dovuta, secondo buona parte degli studiosi, alla pressione dell’italiano standard, in particolare a quella del periodo a partire dalla fine degli anni Sessanta, con la scolarizzazione di massa e la diffusione dei mass-media, specialmente della televisione (Galli De’ Paratesi, 1984; Sobrero, 1997; Berruto, 1997 e 2005; Binazzi, 1997, 1998 e 2007; Cardinaletti e Munaro, 2009). La novità di questa proposta risiede nel fatto che, per la prima volta, ci si è avvalsi di dati di parlato spontaneo in diacronia per verificare la perdita o meno dei pronomi clitici soggetto in fiorentino e osservare eventuali riconfigurazioni dell’espressione del soggetto. I corpora utilizzati sono il corpus Stammerjohann (Stammerjohann 1970; Signorini e Tucci 2005; Scarano e Moneglia 2005) e il Corpus di confronto diacronico LABLITA (Scarano 2005). La possibilità di avere a disposizione corpora che forniscono dati diacronici comparabili è unica, sfruttata sinora solamente per studi di tipo lessicale (Moneglia et al. 2006). Si ritiene dunque che questo lavoro apra le porte ad una prospettiva nuova sull'approccio della perdita dei clitici soggetto nel vernacolo fiorentino. L’articolo è suddiviso come segue: nel primo paragrafo saranno esposte le particolarità morfosintattiche dei pronomi soggetto del vernacolo fiorentino rispetto all’italiano. Nel secondo verranno presentati i corpora consultati: il Corpus Stammerjohann e il Corpus per il Confronto Diacronico. Il terzo paragrafo esporrà la metodologia utilizzata nell’analisi dei dati, a cui è dedicato il quarto paragrafo. Infine, il quinto paragrafo conclude il contributo con una sintesi degli argomenti trattati e una riflessione sugli sviluppi futuri possibili a partire dalla ricerca qui presentata.
Revolución, cuerpo y resistencia en las nuevas políticas feministas árabes (Egipto y Túnez) // Revolution, body and resistance in the new Arab feminist politics (Egypt and Tunis)
Authors: Galián Hernández Laura 
Published: April 2023

ResumenLas revoluciones árabes de 2011, y que aún continúan, han configurado nuevas prácticas políticas feministas en Egipto y Túnez. Estas nuevas prácticas y discursos feministas se diferencian del feminismo de las generaciones anteriores en tres aspectos: dejan de preocuparse por los problemas del “feminismo occidental”, se alejan del feminismo de Estado, y formulan un feminismo que va más allá de las dicotomías coloniales binarias (García 2013; Blaise 2016; Muhanna 2015).Nuestro objetivo en este artículo es demostrar cómo las políticas feministas y de género que surgen en Egipto y Túnez tras los levantamientos de 2011 responden por un lado, a una larga trayectoria del movimiento feminista árabe en estos dos contextos nacionales, y por otro, a las oleadas de politización transnacional que han generado repertorios de acción colectiva autónomos, horizontales y descentralizados y que han descolonizado, en última instancia, las políticas feministas en su relación con el espacio público y en su forma de performar el género y habitar espacios en disputa (Butler 1990; Soto Villagrán 2003).Palabras clave: Egipto, Túnez, feminismo decolonial, revoluciones árabes, género, espacio. AbstractThe 2011 Arab Revolutions and that still continues have configurated new feminist political practices in Egypt and Tunisia. These new feminist approaches do differentiate themselves from those of the previous generations in three aspects: they no longer worry about the same issues as “Western feminism”, they get away from State feminism, and they formulate a feminism that goes beyond the colonial binary dichotomies (García 2013; Blaise 2016; Muhanna 2015).Our main goal with this article is to demonstrate how gender and feminist politics that emerged in Egypt and Tunis after the 2011 uprisings respond on the one hand, to a long history of the Arab feminist movement in these two national contexts, and, on the other hand, to the waves of transnational politization that have generated autonomous, horizontal and decentralized repertoires of contentious politics that ultimately have decolonized feminist politics, their relation with the public space and in their way of performing gender and inhabit spaces in dispute (Butler 1990; Soto Villagrán 2003). Key Words: Egypt, Tunisia, decolonial feminism, Arab revolutions, gender, space.
Soil-transmitted helminths infection in pregnant women with anemia: a systematic review
Authors: Amiruddin Dianawaty , Su’dan Arifi Jauhary , Hamid Firdaus , Amaruddin Aldian Irma 
Published: April 2023

Background: Soil-transmitted helminths are widespread and grow well in countries with tropical and subtropical climates. It is one of the predispositions to anemia for pregnant women during pregnancy. This condition has long-term adverse effects on mothers and their children, causing the need for serious discussion and treatment.
Methods: This systematic review uses pre-existing research by collecting data from valid sources such as Pubmed, Google Scholar, and NCBI, using the inclusion and exclusion criteria that have been determined.
Results: Based on the vast amount of research that has previously been conducted, it was found that there is a close relationship involving the soil-transmitted helminth infection and various types of worms infecting pregnant women, which causes anemia. Pregnant women need nutrients and increased blood volume during pregnancy. However, the infection interferes with the absorption of micronutrients in the gastrointestinal tract, resulting in impaired nutrient transport between the woman and her unborn child.
Conclusion: Soil-transmitted helminth infection is a predisposing factor for anemia in pregnant women and has long-term adverse effects for both mother and child.
Overview of findings on radiographic examination of sialography in patients with sialolithiasis: case serial
Authors: Ida Ayu Kemala Wasita Manuaba  , I Made Dwijaputra Ayusta  , Putu Patriawan  
Published: April 2023

Background: Sialolithiasis is the most common salivary gland disease. Salivary gland disease usually occurs in middle age, with an incidence of 12 in 1000 in the adult population. The peak incidence is between the ages of 30 and 50. Sialolithiasis generally occurs in the submandibular gland. Sialoliths can be single or multiple. Diagnosis of sialolithiasis can be based on clinical examination or simple supporting examination in the form of sialography.
Case Report: There were 3 patients with the main complaint of pain in the lower jaw area with similar symptoms, such as swelling and discomfort every time they chewed food. In all three patients, conventional plain radiographs were examined, namely Skull AP photos, followed by conventional radiological examinations using water-soluble contrast media known as sialography.
Conclusion: Correct diagnosis and determine the appropriate treatment for the patient. Plain AP skull radiographs can be used as an early indication of the presence or absence of sialolith images, although they may not be visible if they are relatively small. Furthermore, sialography examination can become the gold standard in determining the location and size of sialoliths. In these three cases, an opacity or filling defect, accompanied by a dilatation of the proximal duct and even narrowing of the distal lumen of the duct, indicates either partial or total obstruction. An ultrasound examination was performed to confirm the diagnosis. In all three cases, it was found that there was indeed a hyperechoic surrounded by clear anechoic (saliva), thus suggesting a sialolithiasis.
Pathomorphological analysis of the gum tissues in the application of the combination of Soderm®-Forte gel with Cytoflavin® in experimental periodontitis in rats
Authors: Galenko-Yaroshevsky Pavel A. , Slavinskiy Aleksandr А. , Zadorozhniy Mark A. , Leontev Valeriy K. , Kheigetyan Artur V. , Popkov Viktor L. , Zelenskaya Anait V. , Chuprinenko Lyudmila M. , Verevkin Aleksandr А. , Lomsadze Izabella G. , Materenchuk Mariya Yu. , Lebedeva Svetlana A. 
Published: April 2023

Introduction: Periodontitis is one of the most urgent problems of modern dentistry. The development of new paradigms and regimens of combination therapy of patients with periodontitis is a strategic task for pharmacologists and dentists. In view of this, pathomorphological examination is of high importance, since it allow us to conclude about the therapeutic effectiveness of the administered drugs with high objectivity.
Aim of the study: to evaluate the effect of the composition of Soderm®-Forte and Cytoflavin® on the pathomorphological pattern of gum tissues of rats with experimental periodontitis (EP).
Materials and Methods: EP was simulated in rats by ligature method. Study design: animals with intact periodontium; animals with untreated EP; animals with EP treated with traditional drug therapy (TDT); animals with EP treated with the combination of TDT and Soderm®-Forte gel; and animals with EP treated with the combination of TDT, Soderm®-Forte and Cytoflavin®. For pathomorphological examination, biopsy specimen was taken from the gingival margin of the lower incisors. Slides were stained with hematoxylin and eosin, as well as by Masson. Computer morphometry was performed using the ImageJ software.
Results: In EP, TDT has a moderate positive effect on pathomorphological changes in the gum. The combination of TDT and Soderm®-Forte and, to a greater degree, the combination of TDT, Soderm®-Forte and Cytoflavin® have high therapeutic efficacy, characterized by rapid regeneration of the gum tissues.
Conclusion: The combination of TDT, Soderm®-Forte and Cytoflavin® in EP has a more pronounced therapeutic effect, manifested by early regression of pathological changes and acceleration of tissue regeneration in the gum.
Graphical Abstract
Organization of a three-level system of emergency, including emergency specialized, medical care in the constituent entities of the Russian Federation
Authors: Bagnenko S. F. , Teplov V. M. , Tsebrovskaya E. A. , Ihaev A. B. , Moskvina S. S. 
Published: April 2023

Introduction. The article presents an analysis of the problem, justification of the concept and formulates the basic principles of the functioning of a three-level system for organizing the provision of emergency specialized medical care in the constituent entities of the Russian Federation, and also demonstrates the experience of using computer modeling to create it on the example of three constituent entities of the country. Target. Determination of possible ways to optimize the three-level system in the regions through virtual experiments.Methods. A retrospective analysis of data on the current activities of the region was carried out, on the basis of which, with the help of computer simulation, a model of a three-level system was created and experiments aimed at its optimization were carried out. Results. On the basis of data on emergency patients admitted to various hospitals, a simulation model was created, a number of experiments were carried out aimed at determining the optimal redistribution of the flow of patients in need of emergency care in hospitals of the 3rd level, including in emergency situations of a biological and social nature at example of the COVID‑19 pandemic. The effectiveness of the proposed system was demonstrated, in the model it was possible to ensure the timely hospitalization of all patients in the subject to the place of providing them with comprehensive medical care. Conclusion. For the organization of a three-level system of emergency care, including specialized medical care, it is advisable to conduct organizational experiments using simulation modeling, which allows you to correctly plan the redistribution of patient flows, identify possible errors in the virtual model.