bluuebunny/crossref_metadata_2025_split huggingface dataset:
Energy Efficient Real-time Tasks Scheduling on High Performance Edge- Computing Systems using Genetic Algorithm
Authors: Hussain Hameed , Qureshi Muhammad Shuaib , Khan Ayaz Ali , Ahmed Aftab , Rahman Shahid , Rahman Afzal , Zakarya Muhammad , Qureshi Muhammad Bilal 
Published: March 2023

Abstract
With increase in number of processing cores or systems, the high-performance edge-computing system’s power and computation speed will increase essentially. However, this comes at the expense of high-energy utilization. One notable solution to reduce the energy consumption of these system is to execute these systems at the slowest feasible speed so that the job’s deadline times are met. Unfortunately, this method is at the expense of more response time and performance loss. To resolve this issue, in this paper we propose a GA-FiFeS approach that associates genetic algorithm with the first feasible speed (FiFeS) approach. This does not jeopardize real-time task deadlines. The GA-FiFeS proposes an energy-efficient schedule while still ensuring high response times. The results of the proposed approach, using plausible assumptions, are compared with currently in practice approaches i.e. FiFeS and LeFeS. As far as energy usage and response times are concerned, the GA-FiFeSS approach surpasses the FiFeS and LeFeS strategies, respectively.
Comparative Study of Corrosion, Mechanical and Electrical Characteristics of Tungsten inert Gas and Friction Stir Welded Joints
Authors: Kulkarni Bhardwaj , Pankade Sandeep 
Published: March 2023

Abstract
Aluminium alloys are welded using both tungsten inert gas welding (TIG) and friction stir welding (FSW). FSW doesn’t need any filler material and shielding gas which results in reduced degradation of the environment. In the present study, joints with FSW and TIG processes were compared in terms of microstructure, corrosion resistance, mechanical, and electrical properties. With a microstructural study, the average grain size of various regions was determined. Coarse grain increases the rate of exfoliation corrosion. The fine grain structure in the FSW stir zone increases the hardness. The coarse grains are a prerequisite for enhanced electrical conductivity. The coarse grains in the heat-affected zone and thermomechanically affected zones of FSW joints increase electrical conductivity. In the case of friction stir welded joints, there is an inverse relationship between hardness and electrical conductivity. As hardness increases, electrical conductivity decreases, and vice versa. Hence, in the case of FSW hardness test can be substituted by an electrical conductivity test. In the case of TIG, no relation was found between hardness and electrical conductivity. High Silicon content at the weld region of TIG significantly reduces electrical conductivity.
Artists in the mines, quarries and saltworks. Land art or earthworks and ecological art
Authors: Puche Riart Octavio , Ayarzagüena Sanz Mariano 
Published: March 2023

At the end of the 60s of the 20th century, a group of mostly Anglo-Saxon artists began a series of works in a context of social struggle and the beginning of the environmental movement that gave rise to what has been called land art and earthworks. Since then these initiatives have had extensive development. The historical study of these works, their symbolic meaning, their impact on the development of contemporary art and the role played as an engine of development of the territories where such works have been carried out will be the main objective of this work.These artistic works are executed on the territory and remain inextricably linked to it, where man leaves his mark on nature. They are actions that build, destroy or modify the landscape to a greater or lesser extent, since they frequently acquire large dimensions. Since the end of the 20th century, some artistic interventions will be carried out to revalue the landscape of mines, quarries and salt mines, particularly after its closure. It can be said that these works show a certain ephemeral character, depending on the qualities of the geological materials and the climate, being exposed to the direct action of the meteors, and in any case, it is an outdoor art.Ecological or environmental artists will see their initiatives enhanced after the approval of the first protectionist laws in the 70s. These artists work in mines and quarries, mainly from the point of view of landscape and environmental recovery.
Evolution of Immunotherapy Against Pollen Allergy
Authors: Gianni Mistrello 
Published: March 2023

Abstract:
Allergic diseases have increased worldwide during the last century and are a major disease
burden globally. Several substances can induce allergic sensitization and elicit allergic symptoms in
sensitized individuals. Pollen grains are one of the main causes of allergic rhinitis and asthma, and the
prevalence of different pollen species depends on the climate, geographical regions, flora, and seasons.
In addition to avoiding exposure to pollens, anti-allergic drugs are commonly used to mitigate the
symptoms of allergies. However, these drugs need to be administered repeatedly as long as the symptoms
prevail, usually life-long. Allergen immunotherapy (AIT) is currently the only disease-modifying
approach that can prevent the natural progression of the disease (also known as an allergic march),
provide a long-lasting therapeutic effect, and prevent the worsening of the symptoms and the occurrence
of new sensitizations in allergic individuals. Since the pioneering clinical studies conducted more
than 100 years ago using subcutaneously administered pollen extract to treat hay fever, significant advances
have been made in the field of AIT. Starting from this pioneering approach, in this review, we
have discussed the evolution of the products used for AIT with particular emphasis on pollen allergoids,
the chemically modified pollen extracts characterized by lower allergenicity and comparable
immunogenicity, and the different routes of administration used for AIT.
To Evaluate the Association Between Serum Concentration of Vitamin
D and Chronic Periodontitis in Non-menopausal Females: A Clinico
Biochemical Study
Authors: Kaur Jasleen , Kaur Supreet , Sarangal Vandana , Singh Narang Raman Deep , Singh Sahib Tej , Khindri Danish 
Published: March 2023

Background:
Periodontal disease’s initiation and propagation is through a dysbiosis of
the commensal oral microbiota. But recently, through the extraordinary progress, the interrelationship
that exists between periodontal disease and systemic health has been unveiled.
Through various studies, it has been revealed that vitamin D deficiency may be associated with a
greater risk of developing chronic periodontitis and vitamin D supplementation may help to preserve
periodontal health.

Aim:
To find a co-relation between 25-hydroxy vitamin D status and the severity of periodontal diseases.
To evaluate and compare the effect of non-surgical periodontal therapy alone and in combination
with vitamin D supplementation in reducing the severity of periodontal diseases.

Methods:
The present study was conducted on 90 non-menopausal female subjects who divided
into 3 groups. Group I comprised of healthy controls. Group II comprised of patients with moderate
chronic periodontitis who were assigned to receive only Scaling and root planing (SRP). While
group III included patients with moderate chronic periodontitis who were assigned to receive SRP
along with Vitamin D supplementation. The periodontal parameters and serum levels of 25-
hydroxy vitamin D were recorded for all the participants at baseline. Group II and group III participants
were reassessed at an interval of 3 months post-treatment.

Results:
The results indicated that vitamin D deficiency affected periodontal health negatively.
Statistically highly significant improvement was observed in Group III as compared to group II,
signifying the efficacy of vitamin D supplementation adjunctive to SRP.

Conclusion:
Regular evaluation of Vitamin D levels and supplementation to treat the deficiency
may have potential periodontal health benefits.
Inhibiting Monoamine Oxidase in CNS and CVS would be a Promising Approach to Mitigating Cardiovascular Complications in Neurodegenerative Disorders
Authors: Srivastava Princika , Sudevan Sachithra Thazhathuveedu , Thennavan Arumugam , Mathew Bijo , Kanthlal S.K. 
Published: March 2023

Abstract:
The flavoenzyme monoamine oxidases (MAOs) are present in the mitochondrial outer
membrane and are responsible for the metabolism of biogenic amines. MAO deamination of biological
amines produces toxic byproducts such as amines, aldehydes, and hydrogen peroxide, which are significant
in the pathophysiology of multiple neurodegenerative illnesses. In the cardiovascular system
(CVS), these by-products target the mitochondria of cardiac cells leading to their dysfunction and producing
redox imbalance in the endothelium of the blood vessels. This brings up the biological relationship
between the susceptibility of getting cardiovascular disorders in neural patients. In the current
scenario, MAO inhibitors are highly recommended by physicians worldwide for the therapy and management
of various neurodegenerative disorders. Many interventional studies reveal the benefit of
MAO inhibitors in CVS. Drug candidates who can target both the central and peripheral MAO could
be a better to compensate for the cardiovascular comorbidities observed in neurodegenerative patients.
Mitotic Kinase Inhibitors as Therapeutic Interventions for Prostate Cancer:
Evidence from In Vitro Studies
Authors: Javed Aadil , Özduman Gülseren , Altun Sevda , Duran Doğan , Yerli Dilan , Özar Tilbe , Şimşek Faruk , Korkmaz Kemal Sami 
Published: March 2023

Abstract:
Prostate cancer is one of the devastating diseases characterized by genetic changes leading
to uncontrolled growth and metastasis of the cells of the prostate gland and affects men worldwide.
Conventional hormonal and chemotherapeutic agents are effective in mitigating the disease if diagnosed
at an early stage. All dividing eukaryotic cells require mitotic progression for the maintenance of
genomic integrity in progeny populations. The protein kinases, upon activation and de-activation in an
ordered fashion, lead to spatial and temporal regulation of the cell division process. The entry into
mitosis along with the progression into sub-phases of mitosis is ensured due to the activity of mitotic
kinases. These kinases include Polo-Like-Kinase 1 (PLK1), Aurora kinases, and Cyclin-Dependent-
Kinase 1 (CDK1), among others. The mitotic kinases, among others, are usually overexpressed in many
cancers and can be targeted using small molecule inhibitors to reduce the effects of these regulators on
mechanisms, such as regulation of genomic integrity and mitotic fidelity. In this review, we attempted
to discuss the appropriate functions of mitotic kinases revealed through cell culture studies and the
impact of their respective inhibitors derived in pre-clinical studies. The review is designed to elucidate
the growing field of small molecule inhibitors and their functional screening or mode of action at the
cellular and molecular level in the context of Prostate Cancer. Therefore, studies performed specifically
on cells of Prostatic-origin are narrated in this review, culminating in a comprehensive view of the
specific field of mitotic kinases that can be targeted for therapy of Prostate cancer.
E2F1 Reduces Sorafenib’s Sensitivity of Esophageal Carcinoma Cells via
Modulating the miR-29c-3p/COL11A1 Signaling Axis
Authors: Ma Zhifeng , Zhu Ting , Wang Haiyong , Wang Bin , Fu Linhai , Yu Guangmao 
Published: March 2023

Objective:
Esophageal carcinoma (ESCA) is a common malignancy characterized by high morbidity and mortality. Our work managed to dissect the
modulatory mechanism of E2F1/miR-29c-3p/COL11A1 in the malignant progression and sensitivity of ESCA cells to sorafenib.

Methods:
Via bioinformatics approaches, we identified the target miRNA. Subsequently, CCK-8, cell cycle analysis, and flow cytometry were used to check
the biological influences of miR-29c-3p on ESCA cells. TransmiR, mirDIP, miRPathDB, and miRDB databases were used as tools for the
prediction of upstream transcription factors and downstream genes of miR-29c-3p. The targeting relationship of genes was detected via RNA
immunoprecipitation and chromatin immunoprecipitation, which was further validated by dual-luciferase assay. Finally, in vitro experiments
revealed the way E2F1/miR-29c-3p/COL11A1 affected sorafenib’s sensitivity, and in vivo experiments were used to verify the way E2F1 and
sorafenib impacted ESCA tumor growth.

Results:
miR-29c-3p, downregulated in ESCA, could suppress ESCA cell viability, arrest the cell cycle in the G0/G1 phase, and impel apoptosis. E2F1 was
found to be upregulated in ESCA and it could abate the transcriptional activity of miR-29c-3p. COL11A1 was found to be a downstream target of
miR-29c-3p to enhance cell viability, induce cell cycle arrest in S phase, and constrain apoptosis. Cellular and animal experiments together
demonstrated that E2F1 abated the sorafenib’s sensitivity of ESCA cells via miR-29c-3p/COL11A1.

Conclusion:
E2F1 affected the viability, cell cycle, and apoptosis of ESCA cells by modulating miR-29c-3p/COL11A1, and it attenuated the sensitivity of
ESCA cells to sorafenib, shedding new light on the treatment of ESCA.
Effect of Multifactorial Balance Rehabilitation Program on Risk of
Falls and Functional Fitness in Older Adults with Diabetic Peripheral
Neuropathy
Authors: Gupta Garima , Maiya G. Arun , Bhat Shyamasunder N. , Hande H. Manjunatha 
Published: March 2023

Background:
Increasing age and the added disadvantage of diabetic peripheral neuropathy
(DPN) put the individual at a higher risk of falls and reduced functional fitness. However, there
is a dearth of literature on multifactorial balance intervention, especially targeting the needs of older
adults with DPN.

Objective:
The current study aimed to determine the effect of a multifactorial balance rehabilitation
program on fall risk and functional fitness in older adults with DPN.

Methods:
In this pre-post experimental study, 30 independently ambulating older adults (71.2 ±
4.70 years) with DPN, who were at risk of falling (timed up and go score ≥ 9.4 seconds), were
recruited. Along with the standard care, all the participants received 12 weeks of the multifactorial
balance rehabilitation program.

Results:
Fall risk using the Fullerton Advanced Balance scale and functional fitness using the Senior
Fitness Test were measured at baseline and after 12 weeks of the intervention. The intervention
reduced the risk of falling score significantly (MD = 6.17, p < .001). All six parameters of functional
fitness improved after 12 weeks of intervention. The improvement in lower limb strength
(MD = 1.53 times), upper limb strength (MD = 2.48 times), endurance (MD = 16.07 seconds), lower
limb flexibility (MD = 2.02 inches), upper limb flexibility (MD = 1.47 inches), and dynamic
balance (MD = 1.53 seconds) was statistically significant at p < 0.05.

Conclusion:
This study provided encouraging evidence about the potential of multifactorial
balance rehabilitation to reduce the risk of falling and improve functional fitness in older adults
with DPN.
Recent Advances in Biomaterial Design for Bone Regenerative Therapy: A Mini Review
Authors: Hadri Nurulhuda Athirah , Arifin Nursyahida , Ghazalli Nur Fatiha , Shaari Ramizu , Noordin Khairul Bariah Ahmad Amin , Yusop Norhayati 
Published: March 2023

Abstract:
Longevity has been associated with morbidity and an increase in age-related illnesses,
linked to tissue degeneration and gradual loss of biological functions. Bone is an important organ
that gradually degenerates with increasing lifespan. The remodeling phase plays a huge role in
maintaining the ability of bone to regenerate and maintain its stability and function throughout
life. Hence, bone health represents one of the major challenges to elderly citizens due to the increase
of injury associated with bone degeneration, such as fragility and risks of fractures. In the
virtue of improving the regenerative function of bone tissues, a specialized field of bone tissue
engineering (BTE) has been introduced to improve the current strategies in treating bone degenerative
disorders. Most of the research performed in BTE focuses on the optimization of key components
to generate new bone formation, including the scaffold. A scaffold plays a significant role
in establishing the structural form that interconnects major elements of the tissue engineering triad.
To date, many types of biomaterials have been explored in BTE, ranging from natural and
synthetic materials to nanocomposites. However, ideal scaffolds that display excellent biocompatibility
and mechanical properties, approved for clinical practices are yet available. This paper
aims to describe the up-to-date advancements in scaffold for new bone generation, highlighting
the essential elements and strategies in selecting suitable biomaterials for bone repair.
Isoniazid Loaded PCL-PEG Copolymer Nanoparticles for
Sustained Release Application
Authors: Kulkarni Alpana , Betai Priya 
Published: March 2023

Background:
Tuberculosis (TB) is still a major cause of death worldwide, despite
possibly curable therapies. Neurotoxicity, optic neuritis, and severe liver damage
are side effects of isoniazid, a powerful first-line anti-TB drug.

Objective:
We investigated the use of PCL-PEG copolymer to sustain the release of isoniazid
to reduce its adverse effects.

Methods:
In the present work, PCL-PEG copolymer was synthesized and characterized.
Isoniazid-loaded nanoparticles (Inp) were prepared using a PCL-PEG copolymer. Furthermore,
a 23 half factorial design was employed for the optimization of drug and emulsifier
concentration in Inp. Full characterization of the nanoparticles was performed in
terms of drug loading, entrapment efficiency, particle size, zeta potential, and in vitro
drug release. The morphology, FTIR, DSC, and PXRD evaluation of the optimized Batch
Inp F13 were studied. Stability was evaluated by storing the freeze-dried Inp F13 at various
temperatures.

Results:
The entrapment efficiency and drug loading of nanoparticles prepared by double
emulsion solvent evaporation were found to be the highest. The release study revealed
that all batches of nanoparticles exhibited sustained drug release (60.26 - 88.59%) for 5
days. The cytotoxicity study conducted on Mycobacterium tuberculosis revealed a gradual
release of isoniazid from Inp, reaching the maximum (on the 15th day) compared to
plain isoniazid (on the 4th day). At 0.8 μg/mL concentration, the inhibitory activity of Inp
F13 was maintained for 15 days, indicating sustained release of isoniazid.

Conclusion:
The nanoparticles having PCL:PEG in a 95:5 ratio, with 0.5% PVA and initial
drug loading of 3 mg, produced the optimum batch. Isoniazid-loaded PCL-PEG nanoparticles
allowed controlled (sustained) release of isoniazid.
A Dissertation in Preparation – Structure, Methodology, Approach and Content. The Peace Treaty of Szőny (1627) and Its Subsequent Territorial Negotiations (1628–1629) in Light of Péter Koháry’s Correspondence
Authors: MARTON Gellért Ernő 
Published: March 2023

The goal of this paper is to provide an outline of the author’s dissertation in progress in terms of its structure, methodology, approach, and content. This article aims to present the author’s work on this topic so far, so it focuses on the Peace Treaty of Szőny with an emphasis on its subsequent territorial negotiations in light of Péter Koháry’s correspondence. The paper also contains an overview of Habsburg–Ottoman peace treaties, besides a summary of the afore-mentioned peace process. In this article, one can find a survey of the already collected sources (both published and unpublished). The data from these sources was entered into a database which allowed for the quantitative analysis of these exchanges of letters. The aim of the second part is to present a guide for the documents in Hungarian supplemented with examples. The examples are designed to demonstrate how the sources could be published in accordance with the rules of the guide.
Rezumat: Scopul acestei lucrări este să ofere un tur ghidat prin teza de doctorat a autorului în termenii structurii acesteia, a metodei folosite, a abordării şi a conținutului. Articolul îşi propune să prezinte rezultatele cercetării autorului asupra tratatului de pace de la Szőny, punând accentul asupra negocierilor teritoriale subsecvente, în lumina corespondenței lui Péter Koháry. Articolul conține o trecere în revistă a relațiilor Habsburgo-Otomane şi a tratatelor de pace, pe lângă un sumar al negocierilor deja menționate. În acest articol putem găsi un sumar al documentelor deja colectate, atât edite cât şi inedite. Datele din aceste documente au fost integrate într-o bază de date care a permis o analiză cantitativă a acestui schimb de scrisori. Scopul celei de a doua părți a studiului este să ofere un ghid pentru documentele în maghiară şi să-l ilustreze prin exemple. Exemplele sunt alese pentru a demonstra cum ar putea fi publicate aceste surse, în conformitate cu regulile stabilite în acest ghid.
Cuvinte-cheie: Péter Koháry; tratatul de pace de la Szőny (1627); negocierile teritoriale de la Szécsény şi Buda (1628–1629); relații diplomatice Habsburgo–Otomane; analiza cantitativă a unei colecții de scrisori; ghid pentru publicarea unor documente în limba maghiară