bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predictive model of language deficit after removing glioma involving language areas under general anesthesia
Authors: Cui Meng , Guo Qingbao , Chi Yihong , Zhang Meng , Yang Hui , Gao Xin , Chen Hewen , Liu Yukun , Ma Xiaodong 
Published: January 2023

PurposeTo establish a predictive model to predict the occurrence of language deficit for patients after surgery of glioma involving language areas (GILAs) under general anesthesia (GA).MethodsPatients with GILAs were retrospectively collected in our center between January 2009 and December 2020. Clinical variables (age, sex, aphasia quotient [AQ], seizures and KPS), tumor-related variables (recurrent tumor or not, volume, language cortices invaded or not, shortest distance to language areas [SDLA], supplementary motor area or premotor area [SMA/PMA] involved or not and WHO grade) and intraoperative multimodal techniques (used or not) were analyzed by univariate and multivariate analysis to identify their association with temporary or permanent language deficits (TLD/PLD). The predictive model was established according to the identified significant variables. Receiver operating characteristic (ROC) curve was used to assess the accuracy of the predictive model.ResultsAmong 530 patients with GILAs, 498 patients and 441 patients were eligible to assess TLD and PLD respectively. The multimodal group had the higher EOR and rate of GTR than conventional group. The incidence of PLD was 13.4% in multimodal group, which was much lower than that (27.6%, P&lt;0.001) in conventional group. Three factors were associated with TLD, including SDLA (OR=0.85, P&lt;0.001), preoperative AQ (OR=1.04, P&lt;0.001) and multimodal techniques used (OR=0.41, P&lt;0.001). Four factors were associated with PLD, including SDLA (OR=0.83, P=0.001), SMA/PMA involved (OR=3.04, P=0.007), preoperative AQ (OR=1.03, P=0.002) and multimodal techniques used (OR=0.35, P&lt;0.001). The optimal shortest distance thresholds in detecting the occurrence of TLD/PLD were 1.5 and 4mm respectively. The optimal AQ thresholds in detecting the occurrence of TLD/PLD were 52 and 61 respectively. The cutoff values of the predictive probability for TLD/PLD were 23.7% and 16.1%. The area under ROC curve of predictive models for TLD and PLD were 0.70 (95%CI: 0.65-0.75) and 0.72 (95%CI: 0.66-0.79) respectively.ConclusionThe use of multimodal techniques can reduce the risk of postoperative TLD/PLD after removing GILAs under general anesthesia. The established predictive model based on clinical variables can predict the probability of occurrence of TLD and PLD, and it had a moderate predictive accuracy.
Reliability and validity of the ankle inversion discrimination apparatus during walking in individuals with chronic ankle instability
Authors: Shao Xuerong , Kang Ming , Luan Lijiang , Deng Fawei , Adams Roger , Wu Tao , Han Jia 
Published: January 2023

Purpose: 1) to explore the test-retest reliability of a new device for measuring ankle inversion proprioception during walking, i.e., the Ankle Inversion Discrimination Apparatus—Walking (AIDAW) in individuals with or without Chronic Ankle instability (CAI); 2) to assess its discriminant validity in differentiating individuals with or without CAI; 3) to investigate its convergent validity by examining its association with Cumberland Ankle Instability Tool (CAIT) and the Y Balance Test (YBT).Methods: For test-retest reliability, 15 participants with CAI and 15 non-CAI healthy controls were recruited. Participants completed the AIDAW test twice with a 7-day interval. The area under the receiver operating curve (AUC) was obtained as the AIDAW score. The intraclass correlation coefficient (ICC) and MDC90 were calculated. For the validity study, another 20 individuals with CAI and 20 non-CAI healthy controls were involved. The AIDAW scores were analyzed by an independent samples t-test, and the optimal cutoff value of AIDAW scores to best distinguish individuals with CAI was calculated by Youden’s index. Spearman or Pearson correlation analysis was used to analyze the correlation between AIDAW proprioceptive scores and the CAIT and final YBT scores.Results: For test-retest reliability, the ICC values for the CAI, non-CAI, and the whole group were 0.755, 0.757, and 0.761 respectively. The MDC90 of the CAI and non-CAI group was 0.04 and 0.05. Regarding discriminant validity, the AIDAW proprioceptive discrimination scores in the CAI group were significantly lower than those in the non-CAI group (p = 0.003); and the cutoff score for distinguishing CAI from the non-CAI participants was 0.759. For convergent validity, the AIDAW scores were significantly correlated with the functional balance YBT final scores (p = 0.001) and the CAIT scores (p = 0.009).Conclusion: The AIDAW is a reliable and valid device for evaluating ankle inversion proprioception during walking in individuals with and without CAI. AIDAW can be used as a clinical assessment tool to discriminate CAI from non-CAI individuals and to monitor effects of rehabilitation. The AIDAW proprioceptive discrimination scores were significantly and positively correlated with YBT and CAIT scores.
The recovery of homicidal people diagnosed with schizophrenia and schizoaffective disorder—An interpretative phenomenological analysis
Authors: Kovács Asztrik , Ladányi Bence , Farkas Noémi , Stempel Laura , Kiss Dániel , Bittermann Évi , Rácz József 
Published: January 2023

ObjectiveIdentity recovery in people diagnosed with schizophrenia who have committed homicide poses several difficulties. Premorbid mental illnesses, the experience of psychosis, and the absence of cohesive ego functions may result in the inability to integrate the homicidal act into self-identity. Problems with integration increase the risk of recidivism and further mental problems. The aim of the present research was to explore how homicidal people diagnosed with schizophrenia make sense of their actions, and how they identify with the homicide.MethodSix semi-structured interviews were conducted at a long-term psychiatric home with people who had committed homicide and who had been diagnosed with schizophrenia. The interviews were transcribed verbatim and analysed using interpretative phenomenological analysis (IPA), an idiographic method rooted in phenomenologist traditions that focuses on how participants experience and make sense of events in their lives, and how those events affect their identity and sense of self.ResultsThree personal experiential themes were established as a result of the analysis: (1) homicide and responsibility; (2) homicide and self; and (3) control over threats to self and self-evaluation. (1) Homicide was often reported to have been committed in a non-conscious, delusional state that may have led to the loss of self-determination. (2) Our interviewees struggled to integrate their acts into their identities. They distanced themselves from the crime or held multiple, parallel interpretations of the act. (3) Recovering patients experienced the constant threat of entering into a delusional reality and losing control. The importance of control was central to their self-evaluation. The patients appeared to distance themselves from the homicidal act and to regard their delusional selves as a threat to their lives.ConclusionTherapy aimed at bolstering self-control, supporting the integration of the fragmented self, and raising awareness of the connections between delusional reality and standard, intersubjective reality may be helpful in reducing the instability of the self. Therapy aimed at processing complex grief and loss of family is also needed.
Doctor-patient bilateral matching considering diagnosis and treatment perception in the absence of public health resources
Authors: Zhu Wangqi , He Jitao , Guo Hangxin 
Published: January 2023

IntroductionThe public health crisis is one of the main threats affecting the sustainable development of the economy and strengthening the rational allocation of medical resources is essential for building a strong public health system. Therefore, the study of the doctor-patient bilateral matching has important theoretical and practical significance and perception of diagnosis and treatment is taken as a key consideration in the research.MethodsBased on the current situation of the medical industry and the main contradiction between supply and demand of medical services, an evaluation index of doctor-patient satisfaction is constructed in this paper. Then, based on the different forms of evaluation, calculate the doctor's satisfaction and patient's satisfaction respectively. Taking maximizing the overall satisfaction of doctors and patients, maximizing the number of patients and minimizing the workload difference between doctors as the decision-making objectives, considering the upper limit of doctors' working hours as the constraint condition, a multi-objective decision-making model is constructed and solved by NSGA-II algorithm to realize the matching between doctors and patients.ConclusionFinally, through the comparison with NSGA-III algorithm in three dimensions: the degree of convergence to the reference set, the propagation range of the solution and the running time of the algorithm, it is proved that NSGA-II algorithm has good performance in solving the matching problem of medical service supply and demand.
A Critical Appraisal of the Chronic Pain Rate After Inguinal Hernia Repair
Authors: Gram-Hanssen Anders , Öberg Stina , Rosenberg Jacob 
Published: January 2023

Purpose: To critically appraise highly cited studies reporting on the rate of chronic pain after inguinal hernia repair.Methods: Google Scholar was searched on 23 May 2022. We only included publications with more than 10 citations per year since publication and more than 100 citations in total. Both reports of original data and systematic reviews were included. Risk of bias and quality of the included studies were assessed with either the Joanna Briggs Institute Checklist for Prevalence Studies or the AMSTAR 2 depending on study design.Results: Twenty studies were included and evaluated. The rate of chronic postoperative inguinal pain of any degree ranged from 10%–63%, and the rate of moderate-to-severe pain ranged from 1%–18%. All studies reported the rate of pain of any degree, and most studies reported the rate of moderate-to-severe pain influencing daily activities. Studies used different temporal definitions of chronic pain, but most studies defined it as pain persisting either three or six months postoperatively. Ten studies used unvalidated questionnaires or significantly modified versions of validated questionnaires. Eleven studies primarily included patients receiving open repair. Included studies had median 21 citations per year (range 10–39) and median 387 citations in total (range 127–788).Conclusion: The rates of chronic postoperative inguinal pain reported in the included highly cited studies are possibly inaccurate, excessive, and outdated. New prospective studies based on uniform definitions and standards of measurement are warranted to better assess a contemporary chronic pain rate after inguinal hernia repair.
Integrated Metabolomic and Transcriptomic Analysis Reveals That Amino Acid Biosynthesis May Determine Differences in Cold-Tolerant and Cold-Sensitive Tea Cultivars
Authors: Cheng Yaohua , Ban Qiuyan , Mao Junlin , Lin Mengling , Zhu Xiangxiang , Xia Yuhui , Cao Xiaojie , Zhang Xianchen , Li Yeyun 
Published: January 2023

Cold stress is one of the major abiotic stresses limiting tea production. The planting of cold-resistant tea cultivars is one of the most effective measures to prevent chilling injury. However, the differences in cold resistance between tea cultivars remain unclear. In the present study, we perform a transcriptomic and metabolomic profiling of Camellia sinensis var. “Shuchazao” (cold-tolerant, SCZ) and C. sinensis var. assamica “Yinghong 9” (cold-sensitive, YH9) during cold acclimation and analyze the correlation between gene expression and metabolite biosynthesis. Our results show that there were 51 differentially accumulated metabolites only up-regulated in SCZ in cold–acclimation (CA) and de–acclimation (DA) stages, of which amino acids accounted for 18%. The accumulation of L-arginine and lysine in SCZ in the CA stage was higher than that in YH9. A comparative transcriptomic analysis showed an enrichment of the amino acid biosynthesis pathway in SCZ in the CA stage, especially “arginine biosynthesis” pathways. In combining transcriptomic and metabolomic analyses, it was found that genes and metabolites associated with amino acid biosynthesis were significantly enriched in the CA stage of SCZ compared to CA stage of YH9. Under cold stress, arginine may improve the cold resistance of tea plants by activating the polyamine synthesis pathway and CBF (C-repeat-binding factor)–COR (cold-regulated genes) regulation pathway. Our results show that amino acid biosynthesis may play a positive regulatory role in the cold resistance of tea plants and assist in understanding the cold resistance mechanism differences among tea varieties.
Insect Antifeedant Benzofurans from Pericallis Species
Authors: Díaz Carmen E. , Fraga Braulio M. , G. Portero Adriana , Brito Iván , López-Balboa Carmen , Ruiz-Vásquez Liliana , González-Coloma Azucena 
Published: January 2023

In this work, we have studied the benzofurans of Pericallis echinata (aerial parts and transformed roots), P. steetzii (aerial parts and transformed roots), P. lanata (aerial parts), and P. murrayi (aerial parts and roots). This work has permitted the isolation of the new benzofurans 10-ethoxy-11-hydroxy-10,11-dihydroeuparin (10), (-)-eupachinin A ethyl ether (12), 11,15-didehydro-eupachinin A (13), 10,12-dihydroxy-11-angelyloxy-10,11-dihydroeuparin (14), 2,4-dihydroxy-5-formyl-acetophenone (15) isolated for the first time as a natural product, 11-angelyloxy-10,11-dihydroeuparin (16), and 12-angelyloxyeuparone (17), along with several known ones (1–9, 11). In addition, the incubation of the abundant component, 6-hydroxytremetone (1), with the fungus Mucor plumbeus has been studied. Benzofurans in the tremetone series (1, 1a, 2–5, 18, 18a), the euparin series (6, 7, 7a, 8–10, 14, 16), and the eupachinin-type (11, 12) were tested for antifeedant effects against the insect Spodoptera littoralis. The antifeedant compounds (1, 4, 6, 11, 12) were further tested for postingestive effects on S. littoralis larvae. The most antifeedant compounds were among the tremetone series, with 3-ethoxy-hydroxy-tremetone (4) being the strongest antifeedant. Glucosylation of 1 by its biotransformation with Mucor plumbeus gave inactive products. Among the euparin series, the dihydroxyangelate 14 was the most active, followed by euparin (6). The eupachinin-type compounds (11, 12) were both antifeedants. Compounds 4, 11, and 12 showed antifeedant effects without postingestive toxicity to orally dosed S. littoralis larvae. Euparin (6) had postingestive toxicity that was enhanced by the synergist piperonyl butoxide.
Stato costituzionale di diritto e carcere
Authors: Caputo Giuseppe 
Published: January 2023

A partire dall’analisi della giurisprudenza costituzionale in materia di detenzione, nell’articolo si propone una teoria costituzionale dei diritti irrinunciabili della persona privata della libertà personale. Questa viene elaborata a partire dalla critica alla tradizionale teoria liberale dell'insindacabilità del governo amministrativo del carcere e alla più recente teoria del primato della rieducazione. Entrambe risultano incompatibili con il principio del primato della persona sancito dallo stato costituzionale di diritto. A partire dall’articolato reasoning della Corte, viene proposta una teoria utilitaristica dei diritti dei detenuti basata sul principio della minima sofferenza necessaria e su quello della giurisdizionalizzazione del carcere.
The article presents a constitutional theory of the inalienable rights of the person deprived of personal liberty, based on the constitutional jurisprudence on detention. The theory is elaborated from the critique of the traditional liberal theory of the unquestionability of the administrative government of the prison and of the more recent theory of the primacy of re-education. Both are considered incompatible with the principles of the constitutional rule of law based on the respect of fundamental human rights. Starting from the articulated reasoning of the Court, the article proposes a utilitarian theory of the rights of prisoners based on the principles of the minimum necessary suffering and of the jurisdictionalization of the prison.
Divortium e tutela del coniuge “debole”: mulier, uxor, mater
Authors: Rossi Francesca 
Published: January 2023

Il presente contributo propone una breve rifl essione sulla tutela del coniuge “debole” nel diritto romano, alla luce degli strumenti previsti a favore della donna a seguito dello scioglimento del matrimonio. A tal fi ne, sono presi in esame gli istituti della dote e della donazione nuziale (ante e propter nuptias), quali apporti patrimoniali funzionali alla vita coniugale. In particolare, viene considerato il regime giuridico di entrambi in conseguenza del divorzio, attraverso un riferimento alla restituzione e alle trattenute dotali (retentiones), nonché all’usufrutto legale della donazione nuziale in favore della moglie. Il lavoro si sofferma poi sull’obbligo alimentare nei confronti della prole, come risultante dal senatoconsulto Planciano, relativo al riconoscimento dei fi gli nati post divortium. In ciascuno di tali istituti emerge non soltanto una logica di favor mulieris, ma anche e soprattutto di favor matris, suggerendo la conclusione che si tratti di strumenti volti alla tutela della donna in quanto mater (oltre che moglie), più che della donna in quanto (semplicemente) uxor.
This paper proposes a brief refl ection on the protection of the “weak” spouse in Roman law, in the light of the instruments provided for women following thedissolution of marriage. To this end, the institutes of dowry and nuptial donation (ante and propter nuptias) are examined, as capital contributions functional to married life. In particular, the legal regime of both is considered as a consequence of divorce, through a reference to restitution and dotal withholdings (retentiones), as well as the legal usufruct of the nuptial gift in favour of the wife. The work then dwells on the alimony obligation towards the offspring, as resulting from the senatus consultum Plancianum on the recognition of children born post divortium. In each of these institutions there emerges not only a logic of favor mulieris, but also and especially of favor matris, suggesting the conclusion that these are instruments aimed at protecting women as mater (as well as wife) rather than women as (simply) uxor.
Il coniuge (troppo) debole: aporie e persistenze dell'ordinamento familiare ottocentesco
Authors: Malpassi Stefano 
Published: January 2023

Con l’avvento della codificazione anche un tema privatissimo come quello matrimoniale trova una sanzione da parte del potere pubblico: il mito della leggeinveste la sfera familiare. Durante tutto il corso dell’Ottocento il dibattito ruoterà soprattutto intorno al tema della tenuta morale e patrimoniale della famiglia,finendo per consacrarne l’ordinamento gerarchico. L’apparente contraddizione con le aspirazioni rivoluzionarie si risolve, al contrario, proprio nella tutela degli assunti di base del liberalismo ottocentesco: individualismo, proprietà, ordine politico. I nuovi codici sembrano trovare, infatti, proprio nella formulazione «della forte famiglia nel forte Stato» (Ungari, 1974) una chiusura del cerchio, la compiuta affermazione dell’ordine borghese che in materia di famiglia consacra un «ordine sociale laicizzato» (Passaniti, 2011). Protagonista ‘riflessa’ di questo dibattito è, ovviamente, la figura femminile, «destinataria di un trattamento giuridico differenziato» (Stolzi, 2019) e la cui «debolezza» è un vero «problema» da regolare in funzione della tenuta – anche e soprattutto – patrimoniale della famiglia. Una sintetica ricostruzione degli assetti normativi e dei dibattiti in Francia, prima, e in Italia, poi, sugli effetti dello scioglimento del matrimonio, permette di disvelare alcuni aspetti delle costruzioni liberal-ottocentesche che hanno condizionato a lungo il nostro ordinamento familiare.
Nineteenth-century codifi cation drives the private issue of marriage under the eye of the public power, and the family undergoes the «mythology» of legal positivism. The consequence of the legal debate, which revolves all around the moral and patrimonial hold of the family, is the consecration of its hierarchical order. The seeming contradictions with revolutionary aspirations are resolved in the pillars of nineteenth-century liberalism: individualism, property, political order. The formula «a strong family under a strong state» (Ungari, 1974) conveyed by the codes expresses the achievement of the bourgeois order devoted to a «secularist social order» (Passaniti, 2011) in matters of the family. A prominent, yet refl ected role is played by the woman, «recipient of differentiated legal treatment» (Stolzi, 2019) and whose «weakness» represents an issue which to be solved in order to defend the family’s property asset. After a quick survey of the legal acts and debates on the consequences of the end of marriage, both in France and Italy, this paper aims to unveil the uncertainties and continuities of the traditional-liberal legal order that have long infl uenced the Italian family system.
Influence of electromagnetic waves on the penetration of an antiseptic in the dentine of the tooth root in experimental conditions
Authors: Solomatina N. N. , Postnikov M. A. , Trunin D. A. , Chigarina S. E. , Solomatina A. O. , Kudryashov D. N. , Golovachev A. M. 
Published: January 2023

Aims. To analyse the impact of electromagnetic oscillations in the sound range on diffusion the 3.25 % solution of sodium hypochlorite in the dentine of the tooth root.Materials and methods. A pilot study on diffusion of 3.25% of solution of sodium hypochlorite with dye fuchsine red was executed on 100 extracted teeth of the person. The control group was made by 40 teeth, the introduction of an antiseptic was conducted without use of sound waves. The main group of 60 teeth was divided into 3 subgroups. For the purpose of intensifying of the penetration of an antiseptic in each subgroup, electromagnetic oscillations (frequency range around 20,000 Hz) were applied with exposition time respectively 1 minute, 2 minutes, 3 minutes.Results. Application of sound waves in the canal of a tooth root led to augmentation of penetration of an antiseptic in the system of dentinal canaliculus and microchannels of the tooth root dentine.Conclusions. This process took place most effectively in single-root teeth when exposed to sound vibrations, smaller efficiency is revealed in multirooted teeth that indicates the difference in physical properties of the tissues of the various groups of the teeth.