bluuebunny/crossref_metadata_2025_split huggingface dataset:
PELATIHAN PEMANFAATAN METAVERSE DALAM PEMBELAJARAN DI SMA NEGERI 1 BATANGHARI
Authors: Sari Raras Kartika , Ahmad Imam , Puspaningtyas Nicky Dwi , Alita Debby , Sena Fikih Yuhada , Santika Yuli , Rani Ni Made Suka 
Published: September 2023

AbstractThis activity was carried out with the aim of providing Metaverse training in learning at SMA Negeri 1 Batanghari. The purpose of implementing this training is to provide new insights and knowledge for students about the Metaverse. Metaverse training activities in learning are carried out with offline training for class XII school students. The training was carried out with the first stages, namely providing field surveys, pre-tests, providing training and post-tests. After being given presentation of material about Metaverse, an average of 99.4% of students gave a positive response to the implementation of the activity.Student agree that Metaverse can increase interest in learning, Metaverse can help in understanding thematerial, help to be more active in learninf, increase learning motivation and Metaverse is very easy to use in the learning process. This is because Metaverse is the new Technologi in learning process.Keywords: training, metaverse, learningAbstrakKegiatan ini dilaksanakan dengan tujuan untuk memberikan pelatihan Metaverse dalam Pembelajaran di SMA Negeri 1 Batanghari. Tujuan dari pelaksanaan pelatihan adalah untuk memberikan wawasan dan pengetahuan baru bagi peserta didik tentang Metaverse. Kegiatan pelatihan Metaverse dalam pembelajaran dilaksanakan secara tatap muka kepada peserta didik kelas XII. Pelatihan dilaksanakan dengan tahapan awal yaitu melaksanakan survey lapangan, pemberian pre tes, pelaksanaan pelatihan, dan pemberian post test. Setelah pelaksanaan pelatihan Metaverse, rata-rata 99,4% peserta didik memberikan respon positif terhadap pelaksanaan pelatihan Metaverse. Peserta didik memberikan respon positif dan setuju bahwa Metaverse dapat membuat peserta didik tertarik pada pembelajaran, lebih dapat memahami materi, lebih aktif dalam pembelajaran, lebih termotivasi dalam pembelajaran, dan dapat membuat peserta didik lebih mudah dalam belajar, lebih mudah digunakan saat pembelajaran. Peserta didik sangat antusias saat mengikuti pelatihan, hal ini dikarenakan Metaverse merupakan tekhnologi baru yang mereka gunakan dalam pembelajaran. Kata kunci: pelatihan, metaverse, belajar
PELATIHAN PERENCANAAN KEUANGAN BAGI SISWA-SISWA MUHAMMADIYAH KOTA AGUNG
Authors: Sari Tridarma Rosmala 
Published: September 2023

AbstrakPelatihan perencanaan keuangan bertujuan untuk meningkatkan pengetahuan para siswa dalam mengelola keuangan sejak dini, terutama pada peningkatan kemampuan mereka dalam menggunakan aplikasi perencanaan keuangan pribadi. Saat ini siswa-sisi SMA Muhammadiyah Kota Agung masih kesulitan dalam mengelola keuangannya, tidak melakukan pencatatan terhadap pemasukan dan keuangan dan sulit untuk membuat anggaran keuangan, hal ini dapat berdampak pada kurangnya kemampuan dalam mengelola dan mengatur keuangan. Hasil dari pelatihan ini adalah meningkatnya kemampuan para siswa-siswi dalam menggunakan aplikasi perencanaan keuangan pribadi, sehingga mereka dapat lebih baik dalam melakukan perencanaan, pengelolaan dan pengawasan keuangan. Kata kunci: Perencanaan keuangan, Platform Digital, Pelatihan.
“APPROACH IS MERELY A LENS…”: A STYLISTIC ANALYSIS OF LITERATURE CLASSROOM DISCOURSE
Authors: Afrianto Afrianto , Adriansyah Mohamad 
Published: September 2023

This study looks at the lecturer's linguistic style when delivering material on literary criticism. In this instance, the emphasis is on the stylistic analysis to expose the usage of figurative language and its role in the dialogue between the lecturer and the students. Therefore, the purpose of this study is to examine the figurative language used by a lecturer in a literary class. This study employs the qualitative technique and selects a participant based on the requirements of having a master's degree, having 10 years of teaching experience, and being recommended in order to have an in-depth talk. The data, which are expressed as words, phrases, or sentences, are acquired from audio-video recordings of spoken speech. The recording was made during a lecture in a classroom to obtain an actual situation of the recordings. Furthermore, this study discovered twelve types of figurative language used by the lecturer: metaphor, simile, personification, apostrophe, metonymy, synecdoche, symbol, allegory, paradox, irony, hyperbole, and litotes. Also, each figurative language has a function to convey a particular meaning; comparison, association, and contrast. In addition, the results demonstrate that through the use of figurative language, the lecturer has more alternative ways to expand on the learning subject in the classroom and to enhance students' awareness of stylistics in the form of figurative language.
PERANCANGAN PROTOTIPE DETEKSI KEBOCORAN GAS MENGGUNAKAN SENSOR MQ-6 UNTUK RUMAH TANGGA
Authors: Pandega Dimas Marsus , Marcos Hendra 
Published: September 2023

Sudah tidak asing lagi dengan penggunaan gas LPG di lingkungan sekitar. Karena gas LPG sangat ramah lingkungan serta mempermudah masyarakat dalam penggunaan. Semakin mudah tetapi tidak terlepas dari bahaya yang dihadapi. Kebocoran gas adalah suatu kejadian menyebarnya gas pada tempat yang tidak seharusnya. Apabila gas menyebar didalam ruangan yang tertutup maka akan menimbulkan resiko yang tinggi seperti ledakan ataupun kebakaran. Kebocoran gas sulit dideteksi karena yang telah diolah tidak berbau dan tidak berwarna. Tujuan dari penelitian ini adalah untuk menciptakan rancangan alat deteksi kebocoran gas menggunakan sensor MQ-6, Arduino Uno, Relay, Jumper, Resistor, Buzzer, LCD 16 x 4, Potentiometer, LED, dan Bearboard. Cara kerja rancangan ini apabila sensor MQ-6 mendapati adanya gas didalam ruangan maka buzzer langsung berbunyi dan led merah hidup disertai dengan peringatan bahaya melalui lcd.
Exploring the Preliminary Effects of Resistance Training on Total Brain-Derived Neurotrophic Factor (BDNF) Levels in Elderly Individuals: A Pilot Study
Authors: Eidukaitė Skaistė , Masiulis Nerijus , Kvedaras Mindaugas 
Published: September 2023

Background: Studies have shown that exercise modulates brain-derived neurotrophic factor (BDNF) levels, and resistance training, in particular, has received increasing attention for its potential to enhance BDNF production. Most studies investigating exercise-induced BDNF changes have focused on free or mature BDNF, while the measurement of total BDNF, encompassing both proBDNF and mature BDNF, may provide a more comprehensive understanding of BDNF regulation. This pilot study aimed to explore the preliminary effects of resistance training on total BDNF levels in elderly individuals participating in a resistance training program.
Methods: A small sample of participants (n=6) was recruited and engaged in a structured resistance training program for 12 weeks, with 6 participants in a control group. Total BDNF levels were measured at baseline and post-intervention using reliable laboratory assessments. Additionally, an isokinetic dynamometer was used to determine muscle strength to explore the effect of the resistance training program on muscle performance.
Results: The findings revealed a significant increase in total BDNF levels following the 12 week resistance training intervention (p<0.05). However, improvements in physical performance measures, knee extension peak torque and isometric maximal voluntary contraction, were not observed.
Conclusion: In conclusion, this pilot study provides preliminary evidence of the positive effects of a 12 week resistance training intervention on total BDNF levels. The measurement of total BDNF levels serves as an important marker in assessing the response to resistance training. Further research with larger sample sizes and longer intervention periods is warranted to further explore the relationship between resistance training and total BDNF levels and to confirm these preliminary findings. Understanding the impact of resistance training on total BDNF levels can have implications for optimizing training programs and potentially improving exercise-related outcomes.
Keywords: muscle strength, exercise, brain-derived neurotrophic factor, neuroplasticity, healthy ageing.
Reliability and Validity of Colorado Learning Attitudes about Science Survey (CLASS)
Authors: Badeo Jeah May , Duque Domarth Ace 
Published: September 2023

This study aimed to propose revisions in the psychometric properties of Colorado Learning Attitudes for Science Survey (CLASS) based on the evidence found from this study. CLASS is a 42-item instrument that measures studentsâ€™ attitudes towards physics and learning physics. In determining the validity of CLASS, 227 senior high school students from different schools in Metro Manila and Â in Cavite, Philippines participated in the study. Statements in CLASS underwent exploratory factor analysis through principal factor analysis to determine its factor structure. Results showed that from the original 42 items in CLASS, 13 items did not reach acceptable correlation coefficient and factor loadings, thus they were deleted. From the remaining 29 items, four categories emerged: Personal Interest and Real-World Connection, Sense Making/Effort and Problem Solving, Conceptual Connections, and Applied Conceptual Understanding, compared to the eight categories from the original version CLASS. Specifically, the four factors were composed of the following number of items: 8 for Personal Interest and Real-World Connection, 7 for Sense Making/Effort and Problem Solving, 8 for Conceptual Connections, and 6 for Applied Conceptual Understanding. Reliability also reached acceptable overall Cronbachâ€™s alpha value of 0.745. This study proposes this revised 29-item instrument of CLASS as a valid instrument which measures studentsâ€™ attitude in the areas of personal interest, real world connection, personal effort and approaches in a physics course, and to problem solving.
Intra-articular delivery of micronized dehydrated human amnion/chorion membrane reduces degenerative changes after onset of post-traumatic osteoarthritis
Authors: Lin Angela S. P. , Reece David S. , Thote Tanushree , Sridaran Sanjay , Stevens Hazel Y. , Willett Nick J. , Guldberg Robert E. 
Published: September 2023

Background: Micronized dehydrated human amnion/chorion membrane (mdHACM) has reduced short term post-traumatic osteoarthritis (PTOA) progression in rats when delivered 24 h after medial meniscal transection (MMT) and is being investigated for clinical use as a disease modifying therapy. Much remains to be assessed, including its potential for longer-term therapeutic benefit and treatment effects after onset of joint degeneration.Objectives: Characterize longer-term effects of acute treatment with mdHACM and determine whether treatment administered to joints with established PTOA could slow or reverse degeneration. Hypotheses: Acute treatment effects will be sustained for 6 weeks, and delivery of mdHACM after onset of joint degeneration will attenuate structural osteoarthritic changes.Methods: Rats underwent MMT or sham surgery (left leg). mdHACM was delivered intra-articularly 24 h or 3 weeks post-surgery (n = 5–7 per group). Six weeks post-surgery, animals were euthanized and left tibiae scanned using equilibrium partitioning of an ionic contrast agent microcomputed tomography (EPIC-µCT) to structurally quantify joint degeneration. Histology was performed to examine tibial plateau cartilage.Results: Quantitative 3D µCT showed that cartilage structural metrics (thickness, X-ray attenuation, surface roughness, exposed bone area) for delayed mdHACM treatment limbs were significantly improved over saline treatment and not significantly different from shams. Subchondral bone mineral density and thickness for the delayed treatment group were significantly improved over acute treated, and subchondral bone thickness was not significantly different from sham. Marginal osteophyte degenerative changes were decreased with delayed mdHACM treatment compared to saline. Acute treatment (24 h post-surgery) did not reduce longer-term joint tissue degeneration compared to saline. Histology supported µCT findings and further revealed that while delayed treatment reduced cartilage damage, chondrocytes displayed qualitatively different morphologies and density compared to sham.Conclusion: This study provides insight into effects of intra-articular delivery timing relative to PTOA progression and the duration of therapeutic benefit of mdHACM. Results suggest that mdHACM injection into already osteoarthritic joints can improve joint health, but a single, acute mdHACM injection post-injury does not prevent long term osteoarthritis associated with meniscal instability. Further work is needed to fully characterize the durability of therapeutic benefit in stable osteoarthritic joints and the effects of repeated injections.
The performance of tongue swabs for detection of pulmonary tuberculosis
Authors: Ealand Christopher S. , Sewcharran Astika , Peters Julian S. , Gordhan Bhavna G. , Kamariza Mireille , Bertozzi Carolyn R. , Waja Ziyaad , Martinson Neil A. , Kana Bavesh D. 
Published: September 2023

IntroductionOral and/or tongue swabs have demonstrated ability to detect Mycobacterium tuberculosis (Mtb) in adults with pulmonary tuberculosis (TB). Swabs provide useful alternative specimens for diagnosis of TB using molecular assays however, the diagnostic pickup by culture requires further improvement and development. Several studies identified the presence of differentially culturable tubercle bacilli (DCTB) populations in a variety of clinical specimens. These organisms do not grow in routine laboratory media and require growth factors in the form of culture filtrate (CF) from logarithmic phase cultures of Mtb H37Rv.MethodsHerein, we compared the diagnostic performance of sputum and tongue swabs using Mycobacterial Growth Indicator Tube (MGIT) assays, Auramine smear, GeneXpert and DCTB assays supplemented with or without CF.ResultsFrom 89 eligible participants, 83 (93%), 66 (74%) and 79 (89%) were sputum positive by MGIT, smear and GeneXpert, respectively. The corresponding tongue swabs displayed a lower sensitivity with 39 (44%), 2 (2.0%) and 18 (20%) participants respectively for the same tests. We aimed to improve the diagnostic yield by utilizing DCTB assays. Sputum samples were associated with a higher positivity rate for CF-augmented DCTB at 82/89 (92%) relative to tongue swabs at 36/89 (40%). Similarly, sputum samples had a higher positivity rate for DCTB populations that were CF-independent at 64/89 (72%) relative to tongue swabs at 26/89 (29%). DCTB positivity increased significantly, relative to MGIT culture, for tongue swabs taken from HIV-positive participants. We next tested whether the use of an alternative smear stain, DMN-Trehalose, would improve diagnostic yield but noted no substantial increase.DiscussionCollectively, our data show that while tongue swabs yield lower bacterial numbers for diagnostic testing, the use of growth supplementation may improve detection of TB particularly in HIV-positive people but this requires further interrogation in larger studies.
Progressive alterations of left atrial and ventricular volume and strain across chronic kidney disease stages: a speckle tracking echocardiography study
Authors: Nguyen Hoai Thi Thu , Do Chien Van , Dang Dieu Thi Vu , Do Loi Doan , Doan Linh Huu , Dang Ha Thi Viet 
Published: September 2023

BackgroundIt has been a scarcity of evidence regarding differences in left ventricular (LV) and left atrial (LA) size and strain changes across stages of chronic kidney disease (CKD) and which echocardiographic parameters could be utilized to predict the decline of glomerular filtration rate (GFR).ObjectivesThis study aimed to evaluate the alterations of LV and LA strain across the reduction of renal function and potential echocardiographic parameters which could be correlated with the GFR decline among patients with CKD.MethodA cross-sectional study was conducted on 169 CKD patients at Bach Mai General Hospital, Hanoi, Vietnam from April to November 2022. Demographic, clinical and laboratory characteristics of patients were collected. Transthoracic echocardiography was performed to measure LV and LA size and strains. Jonckheere-Terpstra test was used to measure the tendency of change. Multivariate linear regression models were performed to find associations between different echocardiographic parameters and renal function reduction.ResultsThe number of patients with CKD stages 1, 2, 3, 4, and 5 was 21 (12.4%), 28 (16.6%), 27 (16.0%), 22 (13.0%) and 71 (42.0%), respectively. CKD severity was positively associated with LV diastolic and systolic diameters, LV mass, E/e' ratio, and maximal tricuspid regurgitation velocity (TR max), and negatively correlated with the LV global longitudinal strain. Higher severity of CKD stage was associated with higher LA diameter, LA strain, and volume in four and two-chamber views, and lower LA reservoir and conduit function. Left ventricular mass (β = 0.068), ejection fraction (β = 0.112) and left atrial reservoir (β = −0.077) were associated with reduced GFR.ConclusionLeft ventricular mass, ejection fraction, and atrial longitudinal strain by STE should be done at the earlier stages of CKD patients for better follow-up of GFR decline.
Development of a convenient and effective hypertension risk prediction model and exploration of the relationship between Serum Ferritin and Hypertension Risk: a study based on NHANES 2017—March 2020
Authors: Guo Shuang , Ge Jiu-Xin , Liu Shan-Na , Zhou Jia-Yu , Li Chang , Chen Han-Jie , Chen Li , Shen Yu-Qiang , Zhou Qing-Li 
Published: September 2023

BackgroundHypertension is a major public health problem, and its resulting other cardiovascular diseases are the leading cause of death worldwide. In this study, we constructed a convenient and high-performance hypertension risk prediction model to assist in clinical diagnosis and explore other important influencing factors.MethodsWe included 8,073 people from NHANES (2017—March 2020), using their 120 features to form the original dataset. After data pre-processing, we removed several redundant features through LASSO regression and correlation analysis. Thirteen commonly used machine learning methods were used to construct prediction models, and then, the methods with better performance were coupled with recursive feature elimination to determine the optimal feature subset. After data balancing through SMOTE, we integrated these better-performing learners to construct a fusion model based for predicting hypertension risk on stacking strategy. In addition, to explore the relationship between serum ferritin and the risk of hypertension, we performed a univariate analysis and divided it into four level groups (Q1 to Q4) by quartiles, with the lowest level group (Q1) as the reference, and performed multiple logistic regression analysis and trend analysis.ResultsThe optimal feature subsets were: age, BMI, waist, SBP, DBP, Cre, UACR, serum ferritin, HbA1C, and doctors recommend reducing salt intake. Compared to other machine learning models, the constructed fusion model showed better predictive performance with precision, accuracy, recall, F1 value and AUC of 0.871, 0.873, 0.871, 0.869 and 0.966, respectively. For the analysis of the relationship between serum ferritin and hypertension, after controlling for all co-variates, OR and 95% CI from Q2 to Q4, compared to Q1, were 1.396 (1.176–1.658), 1.499 (1.254–1.791), and 1.645 (1.360–1.989), respectively, with P &lt; 0.01 and P for trend &lt;0.001.ConclusionThe hypertension risk prediction model developed in this study is efficient in predicting hypertension with only 10 low-cost and easily accessible features, which is cost-effective in assisting clinical diagnosis. We also found a trend correlation between serum ferritin levels and the risk of hypertension.
Observation and simulation study on the rapid intensification mechanism of Typhoon “Mekkhala” (2006)
Authors: Chen Dehua , Jiang Yongcheng , Huang Xin , Xun Aiping , Dai Huaning , Zhang Hanyun 
Published: September 2023

Based on Doppler Weather radar observations and numerical simulations applying the Weather Research and Forecasting (WRF) system, this study focused on the rapid intensification (RI) of Typhoon “Mekkhala” (2006) in the inshore area in 2020. The simulated track of the typhoon relatively matched with the observation, with a slight eastward bias compared to the observed track. During the phase of RI, there was a slight weakening of vertical wind shear between 200–500 hPa. The temporary decrease in vertical wind shear became a favorable factor for the intensification of the typhoon. In general, vertical wind shear of the lower atmosphere is the key to supporting the RI of Typhoon Mekkhala. In the middle troposphere, the southward component of the vertical wind shear suddenly increases, indicates that the inflow of southern wind to the core of the typhoon had strengthened. Thus, the strengthening of the moisture transport by enhanced southern wind, contributed to the intensification of the typhoon. During the intensification of the typhoon, the low-level vorticity was significantly enhanced, and the high vorticity values expanded from the lower to higher troposphere. The vertical distribution of vorticity transformed from symmetry to asymmetry. The development of secondary circulation on both sides of the typhoon is a dynamic factor for intensification.
Insights into the physiological, molecular, and genetic regulators of albinism in Camellia sinensis leaves
Authors: Zhao Yang , Yang Peidi , Cheng Yang , Liu Yong , Yang Yang , Liu Zhen 
Published: September 2023

Introduction: Yanling Yinbiancha, a cultivar of Camellia sinensis (L.) O. Kuntze, is an evergreen woody perennial with characteristic albino leaves. A mutant variant with green leaves on branches has been recently identified. The molecular mechanisms underlying this color variation remain unknown.Methods: We aimed to utilize omics tools to decipher the molecular basis for this color variation, with the ultimate goal of enhancing existing germplasm and utilizing it in future breeding programs.Results and discussion: Albinotic leaves exhibited significant chloroplast degeneration and reduced carotenoid accumulation. Transcriptomic and metabolomic analysis of the two variants revealed 1,412 differentially expressed genes and 127 differentially accumulated metabolites (DAMs). Enrichment analysis for DEGs suggested significant enrichment of pathways involved in the biosynthesis of anthocyanins, porphyrin, chlorophyll, and carotenoids. To further narrow down the causal variation for albinotic leaves, we performed a conjoint analysis of metabolome and transcriptome and identified putative candidate genes responsible for albinism in C. sinensis leaves. 12, 7, and 28 DEGs were significantly associated with photosynthesis, porphyrin/chlorophyll metabolism, and flavonoid metabolism, respectively. Chlorophyllase 2, Chlorophyll a-Binding Protein 4A, Chlorophyll a-Binding Protein 24, Stay Green Regulator, Photosystem II Cytochrome b559 subunit beta along with transcription factors AP2, bZIP, MYB, and WRKY were identified as a potential regulator of albinism in Yanling Yinbiancha. Moreover, we identified Anthocyanidin reductase and Arabidopsis Response Regulator 1 as DEGs influencing flavonoid accumulation in albino leaves. Identification of genes related to albinism in C. sinensis may facilitate genetic modification or development of molecular markers, potentially enhancing cultivation efficiency and expanding the germplasm for utilization in breeding programs.