bluuebunny/crossref_metadata_2025_split huggingface dataset:
PpHY5 is involved in anthocyanin coloration in the peach flesh surrounding the stone
Authors: Zhao Lei , Zhang Yuanqiang , Sun Juanli , Yang Qiurui , Cai Yaming , Zhao Caiping , Wang Furong , He Huaping , Han Yuepeng 
Published: March 2023

SUMMARYRed coloration around the stone (Cs) is an important trait of canned peaches (Prunus persica). In this study, an elongated hypocotyl 5 gene in peach termed PpHY5 was identified to participate in the regulation of the Cs trait. The E3 ubiquitin ligase PpCOP1 was expressed in the flesh around the stone and could interact with PpHY5. Although HY5 is known to be degraded by COP1 in darkness, the PpHY5 gene was activated in the flesh tissue surrounding the stone at the ripening stages and its expression was consistent with anthocyanin accumulation. PpHY5 was able to promote the transcription of PpMYB10.1 through interacting with its partner PpBBX10. Silencing of PpHY5 in the flesh around the stone caused a reduction in anthocyanin pigmentation, while transient overexpression of PpHY5 and PpBBX10 resulted in anthocyanin accumulation in peach fruits. Moreover, transgenic Arabidopsis seedlings overexpressing PpHY5 showed increased anthocyanin accumulation in leaves. Our results improve our understanding of the mechanisms of anthocyanin coloration in plants.
Paraconiothyrium cyclothyrioides, a novel cutaneous fungal pathogen in a dog and a cat
Authors: Faccin Mayane , Rodrigues Hoffmann Aline 
Published: March 2023

AbstractA dog and a cat presented with pyogranulomatous mycotic pododermatitis. Panfungal PCR and next‐generation sequencing identified Paraconiothyrium cyclothyrioides with 100% identity. Paraconiothyrium cyclothyrioides can rarely cause cutaneous infection and systemic disease in immunocompromised humans. This is the first report of infections in domestic animal species.
The garnet effect on hafnium isotope compositions of granitoids during crustal anatexis
Authors: Chen Long , Yakymchuk Chris , Zhao Kai , Zhao Zifu , Li Dongyong , Gao Peng , Chen Yixiang , Sun Guochao , Liu Zhibin 
Published: March 2023

AbstractRadiogenic Hf isotope disequilibrium during crustal anatexis complicates petrogenetic studies that link sources to sinks in granitoid systems and hinders the applications of Hf isotopes to evaluating long-term crustal growth and evolution. Garnet can be a dominant host of radiogenic Hf in crustal rocks, and its behavior in granitoid sources may play a crucial role in isotopic decoupling between residue and melt. We document covariation between (Gd/Lu)N ratios and εHf(t) in post-collisional granitoids from the Dabie orogen (central China). This covariation reflects different garnet modal contents in the residue during anatexis. Quantitative modeling further confirms the dominant role of mixing between melts derived from garnet-rich and garnet-poor residua in producing the observed covariation patterns, but results are inconsistent with the entrainment of garnet rich in radiogenic Hf in the melt. Our results demonstrate that the garnet effect on Hf isotope ratios during crustal anatexis is a crucial factor in elucidating the granitoid source and complicates interpretations of crustal growth from the global zircon archive.
In-beam $$\gamma $$-ray spectroscopy of $$^{94}$$Ag
Authors: Pereira-López X. , Bentley M. A. , Wadsworth R. , Ruotsalainen P. , Lenzi S. M. , Forsberg U. , Auranen K. , Blazhev A. , Cederwall B. , Grahn T. , Greenlees P. , Illana A. , Jenkins D. G. , Julin R. , Jutila H. , Juutinen S. , Liu X. , Llewelyn R. , Luoma M. , Moschner K. , Müller-Gatermann C. , Singh B. S. Nara , Nowacki F. , Ojala J. , Pakarinen J. , Papadakis P. , Rahkila P. , Romero J. , Sandzelius M. , Sarén J. , Tann H. , Uthayakumaar S. , Uusitalo J. , Vega-Romero J. G. , Vilhena J. M. , Yajzey R. , Zhang W. , Zimba G. 
Published: March 2023

AbstractA recoil-beta-tagging experiment has been performed to study the excited $$T=0$$

T
=
0

and $$T=1$$

T
=
1

states in the odd–odd $$N=Z$$

N
=
Z

nucleus $$^{94}$$

94

Ag, populated via the $$^{40}$$

40

Ca($$^{58}$$

58

Ni,1p3n)$$^{94}$$

94

Ag reaction. The experiment was conducted using the MARA recoil separator and JUROGAM3 array at the Accelerator Laboratory of the University of Jyväskylä. Through correlating fast, high-energy beta decays at the MARA focal plane with prompt $$\gamma $$
γ
rays emitted at the reaction target, a number of transitions between excited states in $$^{94}$$

94

Ag have been identified. The timing characteristics of these transitions confirm that they fall within decay sequences that feed the short-lived $$T=1$$

T
=
1

ground state of $$^{94}$$

94

Ag. The transitions are proposed to proceed within and between the sets of states with $$T=0$$

T
=
0

and $$T=1$$

T
=
1

. Possible correspondence between some of these transitions from analog states in $$^{94}$$

94

Pd has been discussed, and shell-model calculations including multipole and monopole electromagnetic effects have been presented, in order to enable predictions of the decay patterns between the $$T=0$$

T
=
0

and $$T=1$$

T
=
1

states and to allow a theoretical set of Coulomb energy differences to be calculated for the $$A = 94$$

A
=
94

$$T=1$$

T
=
1

analog states.
Existence and Nonexistence for Boundary Problem Involving the p-Biharmonic Operator and Singular Nonlinearities
Authors: Ould El Mokhtar Mohammed El Mokhtar 
Published: March 2023

This article concerns the existence and the nonexistence of solution for the following boundary problem involving the p-biharmonic operator and singular nonlinearities,

Δ

p

2

u
=

u

γ
−
1

u
+
μ

u

−
1
−
α

/

x

β

u

in

Ω

and

u
=
∂
u
/
∂
n
=
0

on

∂
Ω
,

where

4
<
2
p
<
N
,
0
∈

Ω
,

−
∞
<
μ
<

μ

∗

,

=

N
−
2
p

1
−
α

/
p
N
,
p
<
γ
<

p

∗

=
p
N
/
N
−
2
p

is the critical Sobolev exponent,

0
≤
β
<
N

γ
+
α

/

γ
+
1

,

0
<
α
<
1

. Under some sufficient conditions on coefficients, we prove the existence of at least one nontrivial solutions in

E

by using variational methods. By using the Pohozaev identity type, we show the nonexistence of positive solution when

Ω
⊂

ℝ

N

be a bounded, smoothandstrictlystar-shapeddomain,

β
=
0

and

γ
≥

γ

∗

,
=
pN

1
−
α

/

N
−
2
p

1
−
α

−
μ
Np
>

p

∗

=
pN
/
N
−
2
p

.
Beckett’s Spectral Presences
Authors: Morin Emilie 
Published: March 2023

Abstract
Spectrality remains a key motif and metaphor in Beckett’s writing; many of his wandering and destitute creations seem on their way towards another kind of life, uncomfortably close to death, and remarkably close to the spirit world. This article outlines some of the paradoxes that surround Beckett’s relation to the ghost as a dramatic device; it emphasises how uneasily Beckett’s work sits within the tradition of the ghost play, and unravels some of the preoccupations and interests shaping Beckett’s treatment of dialogues with the dead.
‘Kill Two Million of Them’: Institutionalised Hate Speech, Impunity and 21st Century Atrocities in India
Authors: Jacob Cecilia , Kanth Mujeeb 
Published: March 2023

Abstract
Hate speech and incitement have been instrumental in atrocity crimes that have occurred in India, even prior to its independence. These atrocities include targeted killings of minorities based on religious and ethnic identity, and demonstrate persistent features of systematic, orchestrated violence that is fuelled by a Hindu nationalist ideology. This ideology is routinely promulgated at the highest levels of political leadership. This article traces both the historical and institutional character of hate speech and incitement in India to understand its repeated manifestation over time. Through case studies of recent violence, it considers the implications of new legal developments, technology and the covid-19 pandemic on the character and dynamic of hate speech, incitement and atrocity violence in India. It considers key reforms and areas for accountability on which the international community could engage the government and civil society in India on the issue of hate speech and incitement to promote atrocity prevention at the domestic level.
“The Sun is Shining in Salameh”: An American Communist Observes the Nakba
Authors: Polley Gabriel 
Published: March 2023

Abstract
This paper investigates the writing of A.B. Magil, a journalist for the Communist Party of the USA. In Palestine in 1948, he witnessed the birth of the State of Israel and, correspondingly, the creation of the Palestinian refugee crisis. Magil had unfettered access to Jewish military commanders who later joined Israel’s political elite, but also to Palestinian prisoners of war and Communist politicians. He reported from recently ethnically cleansed towns and villages without seeming to recognise the enormity of what had taken place. A close study of Magil’s coverage throw into relief subsequent shifts in the Western left’s understandings of imperialism, (settler-)colonialism and resistance. After returning to the US, he continued his commentary on the Middle East, his later writings revealing how leftist sympathies for Israel were tested throughout the 1950s, including by the Suez Crisis, though without a re-evaluation of the circumstances of Israel’s creation.
Assessment and management of secondary bacterial infections complicating Mpox (Monkeypox) using a telemedicine service. A prospective cohort study
Authors: Moody Samuel , Lamb Thomas , Jackson Eleri , Beech Alison , Malik Nabihah , Johnson Leann , Jacobs Nathan 
Published: March 2023

Introduction During spring 2022, an outbreak of Monkeypox (mpox) emerged as an infection of concern in Europe. Due to the overlapping clinical features of mpox and bacterial infections, diagnosis of concomitant bacterial infection is challenging. In this prospective cohort study, we report the incidence, severity, and progression of patients with secondary bacterial infection complicating mpox infection. Method Data were collected via a bespoke mpox telemedicine service provided by Infection services at North Manchester General Hospital, UK. A diagnosis of secondary bacterial infection was based on the history (balanitis, surrounding erythema, purulent discharge and nasal ulceration) and review of patient-collected medical photography. Patient were reviewed face-to-face where necessary. Results Secondary bacterial infection was diagnosed in 15 of 129 (11.6%) patients with mpox. Three patients with secondary bacterial infection (3/129, 2.3%) required admission to hospital and one patient underwent surgical debridement. Median healing (thus, isolation) times were longer in those with bacterial infection. Discussion In this prospective cohort study of patients with mpox, secondary bacterial infection was infrequent and predominantly mild. The virtual ward and telemedicine follow up allowed for the prompt recognition of secondary bacterial infections and timely antibiotic administration. Due to concerns regarding nosocomial transmission, mild clinical course and limited inpatient bed capacity, we believe this model of outpatient management for mpox (Clade II B.1 lineage) could be replicated in other low risk populations where suitable home isolation facilities exist.
Integrated Analysis of the Association Between Variants at PAX7 and NSCL/P in the Han Population
Authors: Yang Cheng-Wei , You Yue , Sun Jia-lin , Shi Bing , Jia Zhong-Lin 
Published: March 2023

Objective Paired box 7 ( PAX7) has been considered as a candidate gene for non-syndromic cleft lip with or without palate (NSCL/P). However, there is no research for the XXX, and previous studies concentrated on limited variants. This study aimed to conduct sufficiently dense and powerful scans of variants at PAX7 and explored the roles of variants at PAX7 in NSCL/P among the XXX. Design Targeted region sequencing was performed to thoroughly screen variations, followed by a two-phase association analysis. 159 NSCL/P cases and 542 controls were analyzed in phase 1. Then in phase 2, the validation study was performed using 1626 cases and 2255 controls. We also explored the roles of variants at PAX7 gene in NSCL/P subtypes. Additionally, indirect associations were found by calculating LD and haplotypes. Setting The study was conducted in XXX. Patients, participants 159 NSCL/P cases and 542 controls were analyzed in phase 1. Then in phase 2, the validation study was performed using 1626 cases and 2255 controls. Interventions Blood samples were collected. Main outcome measures To explore the association analysis between variants at PAX7 and NSCL/P in XXX. Results The results showed that rs2236810, rs114882979 and rs2236804 were significantly associated with NSCL/P, which were predicted to have regulatory functions. Besides, variants at PAX7 function differently in the NSCL/P subtypes. We also discovered a PAX7 missense variant, NM_001135254 p.A369 V (NM_002584.2:c.1106C > T). Conclusions In summary, we confirmed 3 SNPs at PAX7 were significantly associated with NSCL/P in XXX and identified a missense variant, NM_001135254 p.A369 V (NM_002584.2:c.1106C > T).
Performance of a provincial prehospital trauma triage protocol: A retrospective audit
Authors: Beaumont-Boileau Roxane , Nadeau Alexandra , Tardif Pier-Alexandre , Malo Christian , Emond Marcel , Moore Lynne , Clément Julien , Mercier Eric 
Published: March 2023

Objective To assess the accuracy of a five-step prehospital trauma triage protocol ( Échelle québécoise de triage préhospitalier en traumatologie (EQTPT)) to identify patients requiring urgent and specialized in-hospital trauma care in the Capitale-Nationale region – Québec. Methods The medical records of trauma patients transported by ambulance to one of the five participating emergency departments (EDs) between November 2016 and March 2017 were reviewed. Our primary outcome was the need for one of the following urgent and specialized trauma care: endotracheal intubation in the ED, administration of ≥ 2 blood products in the ED, angioembolization or surgery (excluding single limb surgery) < 24 h and admission to the intensive care unit (ICU) or in-hospital trauma-related death. Results A total of 902 patients were included. The median age was 63 (interquartile range (IQR) 51) and 494 (54.8%) were female. The main trauma mechanism was falls (n = 592), followed by motor vehicle accidents (n = 201). Eighty-two (9.1%) patients required at least one urgent and specialized trauma care. Of those, 44 (53.6%) were identified as requiring transport to a level one trauma centre (steps 1–3), 16 were identified as requiring transport to a centre with a lower level of trauma designation (steps 4–5) while 22 (26.8%) did not meet any of the EQTPT criteria. For steps 1 to 3, the sensitivity was 53.7% (95% confidence interval (CI) 42.9–64.4) and the specificity was 81.7% (95% CI 79.1–84.4) in identifying patients requiring specialized trauma care. Conclusion The EQTPT lacked sensitivity and was poorly specific to identify trauma patients who need specialized in-hospital trauma care.
Predictors of survival in trauma patients requiring resuscitative thoracotomy: A scoping review
Authors: Radulovic Nada , Wu Richard , Nolan Brodie 
Published: March 2023

Introduction Resuscitative thoracotomy (RT) is an emergent procedure to gain access to the thoracic cavity to control hemorrhage and other life-threatening injuries. Data predicting survival is variable. This review aims to highlight key predictors of survival and mortality following RT. Methods The EMBASE database was searched using the following terms: [exp. Thoracotomy] AND [Trauma.mp] AND [exp. Survival OR exp. Mortality]. The search was limited to full-text articles in the English language and publications released up to February 27, 2022. Reference lists of included articles were reviewed to identify other studies meeting inclusion criteria. Results Thirty-seven studies were included. Seventy-six outcome predictors were identified. Prehospital outcome predictors included prehospital vital signs, police transport, cardiopulmonary resuscitation, application of a cervical spine collar, and the number of total prehospital procedures performed. In-hospital variables associated with survival included traumatic cardiac arrest (TCA) in the emergency department (ED), initial ED vital signs and cardiac rhythm, Shock Index Pediatric Age-Adjusted score, location of RT, duration of RT, Focused Assessment with Sonography in Trauma findings, amount of blood products, and amount of administered fluids. Conclusions Our study highlights the disparity of data regarding prehospital outcome predictors for trauma patients requiring RT. Most studies focus on injury-specific and in-hospital variables and do not explicitly look at the TCA population. Further work is needed to better define specific variables implicated in enhanced survival across different care settings and to inform management guidelines within these clinical areas.
Reliability of open globe injury repair surgical videos on the internet for resident education
Authors: Singh Parmar Uday Pratap , Singh Tanu , Ichhpujani Parul 
Published: March 2023

Introduction This study aimed to assess quality of surgical training videos for management of open globe injury (OGI) on online platforms. Material and Methods Twenty-three websites with surgical training videos were queried using the search keyword “open globe repair.” Video content characteristics and quality assessment scores using Sandvik score, Health on the Net Foundation Code of Conduct (HON code), mDISCERN scoring, and global quality score (GQS) were recorded. To evaluate the relevance of the surgical videos to the surgical procedure, steps were analyzed as per the Ophthalmology Surgical Competency Assessment Rubric (OSCAR) for Open Globe Surgical Management. Results One hundred and twenty-three videos were evaluated, and 63 analyzed. Majority videos were uploaded by solitary ophthalmologists (53/63; 84.13%). Mean video quality score (VQS) and GIS scores were 6.55 ± 1.59 and 7.95 ± 1.39, respectively. Mean mDISCERN, GQS, HON Code and Sandvik scores for all the videos were 2.87 ± 1.07, 3.77 ± 1.08, 5.14 ± 1.67, 12.06 ± 1.84, respectively. Videos with background audio and descriptive subtitles had significantly better quality ( p < 0.05). All Quality assessment scores showed a statistically significant ( p < 0.000) positive correlation with each other. On linear regression analysis, number of video likes, comments and views had a significant ( p < 0.05) positive relation with quality of video, whereas video length showed a negative relation with different scores. Conclusion Nearly two-thirds of surgical videos showing OGI repair had good quality assessment scores. Consensus guidelines should be developed to guide uploaders as regards the essential features required for good quality surgical videos using a standardized rubric.
Acute carpal tunnel syndrome from thrombosed persistent median artery in a patient with congenitally absent radial artery
Authors: Hines Elizabeth Magdelin , Roberts Chris Johnson , Frahm-Jensen Gert 
Published: March 2023

Objectives Thrombosis of the persistent median artery (PMA) is a rare cause of acute carpal tunnel syndrome (ACTS). Existence of a congenitally absent radial artery in this setting has not been described in the literature Methods Computed Tomography Angiography (CTA) and doppler screening were used in pre surgical planning. Open surgical decompression was achieved through the release of the flexor retinaculum in the left hand. A regimen of 100 mg of Aspirin for 3 months time was initiated to encourage clot resolution and recanalization of the thrombosed artery. Results The PMA was found to be abnormally large measuring approximately 4 mm in diameter. Visible clotting off of the PMA in keeping with the doppler scans with maintenance of distal flow and was left intact with the hopes that it would recanalize over time. At the 3-month post-op review the antiplatelet therapy was ceased and the patient was symptom free, demonstrated no signs of ischaemia in the hand, and had returned to full functionality and physical activity Conclusions Although infrequently encountered, the knowledge of the anatomical variations of the forearm and hand together with doppler screening and CTA is essential to the surgical management of ACTS.
Perioperative acute kidney injury: Current knowledge and the role of anaesthesiologists
Authors: Xing Jieyin , Loh Samuel Kent Neng 
Published: March 2023

Background Among the different types of perioperative organ injury, acute kidney injury (AKI) occurs frequently and is consistently associated with increased rates of mortality and mortality. Despite development of many clinical trials to assess perioperative interventions, reliable means to prevent or reverse AKI are still lacking. Objectives This narrative review discusses recent literature on modifiable risk factors, current approaches to prevention and potential directions for future research. Methods A Pubmed search with the relevant keywords was done for articles published in the last 10 years. Results New insights into preoperative identification and optimisation, intraoperative strategies, including the choice of anaesthetic, haemodynamic and fluid management, have been made, with the aim of preventing perioperative AKI. Conclusion A patient-centric multidisciplinary approach is essential to protect kidney function of patients going for surgery. Much can be done by anaesthesiologists perioperatively, to reduce the risk of development of AKI, especially in susceptible patients. There is a need for further multicentred trials to enhance the currently generic perioperative recommendations.
An evaluation of the passing process through road - vehicle parameters assessment
Authors: Mavromatis Stergios , Matragos Vassilios , Apostoleris Konstantinos , Fotos Fotios , Yannis George 
Published: March 2023

Abstract
Purpose
This paper investigates the interaction between vehicle dynamics parameters and road geometry during the passing process.

Methodology
The methodology is based on a realistic representation of the passing task with respect to roadway’s posted speed and the ability of the passing (examined) vehicle to perform such maneuvers. Regarding passing distance outputs, an existing vehicle dynamics model was utilized, where aiming to assess the model’s accuracy, instrumented field measurements were performed. The analytical model is computationally demanding. Therefore statistical models were worked out, in line with the German rural road design guidelines, to determine passing sight distances (PSDs) by arranging combinations of 4 critical vehicle—roadway parameters; namely, vehicle horsepower rates, variations between the passed vehicle’s speed and roadway’s posted speed, peak friction supply coefficients and grade values.

Results
The analysis revealed that the difference between the speed of the passed vehicle and the posted speed value, as well as certain interactions of the assessed parameters impact excessively PSD, especially for values below 20 km/h. The lognormal modelling approach for predicting PSDs was found efficient and may be useful to researchers and practitioners aiming to evaluate the interaction of the utilized road—vehicle parameters in terms of determining PSDs as well as passing zones.

Conclusions
Although more advanced communication between vehicles or between vehicles and road environment seems a prerequisite in order integrated guidance during passing maneuvers to be enabled, the present research consists an opening paradigm of how the passing process can be standardized and therefore deployed in advanced driver assistance systems (ADAS).