bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dirt floors and domestic animals are associated with soilborne exposure to antimicrobial resistantE. coliin rural Bangladeshi households
Authors: Ercumen Ayse , Hossain Md. Sakib , Tabassum Tahani , Haque Ashrin , Rahman Amanta , Rahman Md. Hajbiur , Anderson Claire , Tazin Sumaiya , Hanif Suhi , Barratt Heitmann Gabriella , Miah Md. Rana , Yeamin Afsana , Jahan Farjana , Shoab Abul Kasham , Mahmud Zahid Hayat , Rahman Mahbubur , Benjamin-Chung Jade 
Published: February 2025

AbstractSoil can harbor enteropathogens and antimicrobial-resistant organisms in settings with domestic animals. We enrolled 49 households with young children (28 soil floors, 21 concrete floors) in Bangladesh and recorded animal ownership/management. Staff swabbed the floor of children’s sleeping area with a sterile sponge and collected floor dust and a child hand rinse. We used IDEXX QuantiTray/2000 with and without cefotaxime supplementation to enumerate cefotaxime-resistant and genericE. coli. There was 8.0 g/m2of dust on soil floors vs. 0.2 g/m2on concrete floors (p-value=0.005). We detectedE. colion 100% of soil vs. 86% of concrete floors and cefotaxime-resistantE. colion 89% of soil vs. 43% of concrete floors (p-values<0.05). Cefotaxime-resistantE. coliprevalence on floors was 36% in compounds without animals, 79% in compounds with animals and 100% if animals stayed indoors overnight or the floor had animal feces; associations were strongest for chickens. In multivariable models, generic and cefotaxime-resistantE. colicounts were 1.5-2 log higher on soil vs. concrete floors, and counts on floors and child hands were 0.17-0.24 log higher for every 10 additional chickens owned (p-values<0.05). Efforts to mitigate infections and antimicrobial resistance in low-income countries should test flooring improvements and hygienic animal management.SynopsisIn rural Bangladeshi households, generic and cefotaxime-resistantE. coliwere more common on soil floors than concrete floors and among households with higher cohabitation intensity with domestic animals, especially chickens.
Sensitivity based model agnostic scalable explanations of deep learning
Authors: Aggarwal Manu , Cogan Nick , Periwal Vipul 
Published: February 2025

AbstractMachine learning using deep neural networks (DNNs) has become ubiquitous in data-driven predictive learning. However, their complex architecture often obscures what they have learned from the data. This information is crucial to validate these models when their predictions can affect human life, for example, biological and clinical predictions. We design SensX, a model agnostic explainable AI (XAI) framework to explain what a trained DNN has learned. We introduce the notion of justifiable perturbations to systematically conduct global sensitivity analysis. Benchmarks using synthetic data sets show that SensX outperformed current state-of-the-art XAI in accuracy (up to 50% higher) and computation time (up to 158 times faster), with higher consistency in all cases. Moreover, only SensX scaled to explain vision transformer (ViT) models defined for input images with more than 150, 000 features. SensX validated the ViT models by showing that the features they learn as important for different facial attributes are intuitively accurate. Further, SensX revealed that there may be biases inherent to the model architecture, an observation that is possible only when the model is explained at the full resolution of the input image. Finally, we use SensX to explain a DNN trained to annotate biological cell types using single-cell RNA-seq data sets with more than a million cells and more than 56, 000 genes measured per cell. SensX determines the different sets of genes that the DNNs have learned to be important to different cell types.
Long-read RNA sequencing identifies isoform switching of a novel long non-coding RNA that promotes somatic cell reprogramming
Authors: Fort Victoire , Khelifi Gabriel , Watters Valérie , Yamanaka Nobuko , Micha Victoria , Yamanaka Yojiro , Hussein Samer M.I. 
Published: February 2025

AbstractThe recent development of long-read RNA sequencing (lrRNAseq) technologies has paved the way to the exploration of RNA isoform diversity and its relevance in regulating cell fate and plasticity. However, drawing conclusions regarding the functionality of these newly identified isoforms is still very difficult. Here, we developed a very efficient system to reprogram mouse cells towards induced pluripotent cells and leveraged the strengths of lrRNAseq to study isoform diversity throughout reprogramming. We identified several isoforms derived from novel splice junctions occurring during this process. We demonstrate selective pressure on non-coding isoforms to be tightly regulated. We also show that isoform switching (IS) and diversification play a previously overlooked role in gene regulation to promote functional outcomes for reprogramming. Through IS analysis, we uncovered a novel long non-coding RNA (lncRNA) that undergoes IS during reprogramming to enhance the conversion of cells towards pluripotency. Knock-down of this lncRNA in mouse and human embryonic stem cells decreases the level of expression of pluripotency genes, suggesting that it is required for pluripotent stem cell maintenance. Together, our study provides a comprehensive resource to study full-length isoform usage and switching during reprogramming, but more importantly it demonstrates the power of lrRNAseq to identify functionally relevant gene isoforms in the context of pluripotency.
Chalcogen derivatives for the treatment of African trypanosomiasis: biological evaluation of thio and seleno- semicarbazones and their azole derivatives
Authors: Rubio-Hernández Mercedes , Teixeira Thaiz R. , Nguyen Tina P. , Shingyoji Mai , Barbosa da Silva Elany , O’Donoghue Anthony J. , Caffrey Conor R. , Pérez-Silanes Silvia , Martínez Nuria 
Published: February 2025

ABSTRACTHuman African Trypanosomiasis (HAT) is caused byTrypanosoma brucei. Drug therapy remains challenging due to drug resistance and/or toxicity. New drugs are needed. Using thiosemicarbazones as a starting point, we employed aStoSeisosteric replacement strategy to design 44 analogs which were evaluated againstT. brucei in vitro. Compounds were divided into eleven groups of four derivatives corresponding to thio-, selenosemicarbazones, and their cyclic counterparts, thio- and selenazoles. We selected three groups which contained a total of six derivatives that inhibited parasite growth by >70%. Then, we investigated the mechanism of action of these compounds, performing quantitative assays to measure their inhibition of theT. bruceicathepsin L-like protease (TbrCATL) and DPPH antioxidant activities. The lead compound (SeO3) showed antioxidant capacity and the best activity againstT. brucei(EC50= 0.47 µM). Nevertheless, its toxicity should be improved. We also predicted the interactions of these compounds withTbrCATL utilizing molecular dynamics. We demonstrate that theSederivatives are more active than theirSanalogues, and that the selenazole ring decreasesSe-associated toxicity. Also, thio- and selenosemicarbazones are more potent againstTbrCATL than the cyclic derivatives. We conclude thatTbrCATL inhibition should be combined with antioxidant activity to obtain active compounds againstT. brucei.
Repeatability of protein structural evolution following convergent gene fusions
Authors: Konno Naoki , Miyake Keita , Nishino Satoshi , Omae Kimiho , Yanagisawa Haruaki , Tsuru Saburo , Nishimura Yuki , Kikkawa Masahide , Furusawa Chikara , Iwasaki Wataru 
Published: February 2025

ABSTRACTConvergent evolution of proteins provides insights into repeatability of genetic adaptation. While local convergence of proteins at residue or domain level has been characterized, global structural convergence by inter-domain/molecular interactions remains largely unknown. Here we present structural convergent evolution on fusion enzymes of aldehyde dehydrogenases (ALDHs) and alcohol dehydrogenases (ADHs). We discovered BdhE (bifunctional dehydrogenase E), an enzyme clade that emerged independently from the previously known AdhE family through distinct gene fusion events. AdhE and BdhE showed shared enzymatic activities and non-overlapping phylogenetic distribution, suggesting common functions in different species. Cryo-electron microscopy revealed BdhEs form donut-like homotetramers, contrasting AdhE’s helical homopolymers. Intriguingly, despite distinct quaternary structures and >70% unshared amino acids, both enzymes form resembled dimeric structure units by ALDH-ADH interactions via convergently elongated loop structures. These findings suggest convergent gene fusions recurrently led to substrate channeling evolution to enhance two-step reaction efficiency. Our study unveils structural convergence at inter-domain/molecular level, expanding our knowledges on patterns behind molecular evolution exploring protein structural universe.
Developing a novel copper nano-based emulsified cutting fluid with antimicrobial and anticorrosion properties – an attempt for sustainability
Authors: Al-Aifan Bader , Gouroju Naveen Kumar , Gunamgari Bharath Reddy , N. Aravindan , Balam Durga Prasad , Gangarapu Sai Ram 
Published: February 2025

Purpose
This study aims to develop a copper nano-based emulsified cutting fluid (ECF) with enhanced thermal, antimicrobial and anti-corrosion properties. The study focuses on optimizing the water-to-Triton X-100 (W/TX) ratios and incorporating copper nanoparticles to improve the fluid’s overall efficacy in machining applications.

Design/methodology/approach
Various trial combinations were conducted to determine the optimal W/TX ratios. The as-prepared copper nanoparticles were dispersed in the cutting fluid to enhance its thermo-physical properties. The thermal conductivity, thermal stability and surface spreading capability were measured. Microbial studies identified prevalent microorganisms, particularly Mycobacterium immunogenum. To combat microbial contamination and corrosion, natural biocides (ß-Ionine) and sodium dihydrogen phosphate (NaH2PO4) were added. The corrosion inhibitor efficiency and overall performance were evaluated.

Findings
The inclusion of copper nanoparticles significantly improved the cutting fluid thermal properties, achieving a 51.12% enhancement in thermal conductivity and thermal stability. The surface spreading capability was enhanced with a contact angle of 52.48°. Mycobacterium immunogenum was identified as the most frequent contaminant. The addition of natural biocide ß-Ionine effectively addressed microbial contamination, while 1.4 ml of NaH2PO4 improved the corrosion inhibitor efficiency to 66.94%. The Cu-W/TX cutting fluid demonstrated eco-friendly characteristics with notable antimicrobial and anti-corrosion benefits.

Originality/value
The research work improves ECFs by incorporating copper nanoparticles and optimizing surfactant ratios. It highlights Triton X-100’s potential as a cutting fluid base and the benefits of natural biocides, contributing to more sustainable, efficient fluids with significant environmental and industrial implications.
State capital participation and corporate environmental engagement: evidence from privately-controlled listed firms in China
Authors: Lai Shaojie , Yang Laifeng , Wang Qing Sophie , Anderson Hamish 
Published: February 2025

PurposeThe main purpose of this study is to investigate the impact of state capital participation (SCP) on the corporate environmental engagement (CEE) of privately controlled listed firms in China.Design/methodology/approachWe use a sample of 20,133 firm-year observations from 2009 to 2021. We use three different measures to proxy corporate environmental engagement and two different measures to proxy for state capital participation. We employ a difference-in-difference regression model to estimate the effect of state capital participation on corporate environmental engagement.FindingsUsing a sample of 20,133 firm-year observations from 2009 to 2021, we find that SCP significantly increases corporate expenditure on environmental protection, corporate environmental performance and ESG ratings. Specifically, SCP increases environmental investment capacity and attracts more media coverage, online attention and analysts’ following, which leads to better environmental engagement. Further analyses show that after state shareholders exit privately controlled firms, CEE deteriorates, while private capital injection in state-owned firms has no significant impact on CEE. The positive effect of SCP is stronger in privately controlled firms with local government ownership, a larger number of state shareholders, longer state shareholder holding periods, those without politically connected managers and firms operating in heavy pollution industries. Lastly, we show that minority government ownership reduces firm-level toxic emissions and enhances financial performance.Research limitations/implicationsWe enrich the literature on the role of minority state ownership in corporate financial and environmental performance.Originality/valueWe enrich the literature on the role of minority state ownership in corporate financial and environmental performance. In light of the escalating environmental concerns and the growing emphasis on corporate environmental responsibility, this study highlights the beneficial role of minority government ownership in driving environmental performance. By providing resources and attracting external scrutiny, the government, as a minority shareholder, can significantly enhance the environmental engagement of privately controlled firms.
Exploring the configurational effects of contractual and relational governance mechanisms on stakeholder collaboration in prefabricated building projects
Authors: Zhang Lin , Zhou Jing , Xue Hong 
Published: February 2025

PurposePrefabricated building projects (PBPs) require multiple stakeholder collaboration due to the strong linkages between the design, production and installment of the precast components. Current contractual governance fails to foster a trusting environment for stakeholder collaboration, leading to conflicts of interest, cost overrun and delays in project schedules. Previous studies revealed that terminating shortcomings in contractual governance can be mitigated by implementing relational governance mechanisms. This study aims to explore the configurational effects of contractual and relational governance mechanisms on stakeholder collaboration in PBPs and identifies the practical configurational conditions to achieve high stakeholder collaboration.Design/methodology/approachData were collected from 39 experts through semi-structured interviews and analyzed to explore the configuration effects on stakeholder collaboration in PBPs through fuzzy-set qualitative comparative analysis (fsQCA).FindingsOur study reveals that stakeholder collaboration requires configurational conditions of multiple governance elements (i.e. historical working experience and risk-sharing, reward, selection, authorization, trust, commitment and communication mechanisms). Four equivalent configurational strategies were identified for achieving high stakeholder collaboration in PBPs. These included three configurational strategies dominated by relational governance mechanisms and one configurational strategy complementary to contractual and relational governance mechanisms. The configurations dominated by relational governance mechanisms were developed with communication mechanisms and historical working experiences as core conditions; the configurational strategy with complementary contractual and relational governance mechanisms was centered on risk-sharing, reward and trust mechanisms as core conditions.Originality/valueOur study enriches the literature on the antecedents of stakeholder collaboration in the PBPs by testing the significance of the relational governance mechanism, which expands the implications of relational contract theory. It also expands the implications of stakeholder theory in PBPs by exploring the asymmetric causal relationship between project contractual governance and stakeholder collaboration. Meanwhile, this study recommends countermeasures for managers to improve stakeholder collaboration by providing four practical configurational conditions in PBPs.
Organizational reflections of the relationship between artificial ıntelligence and emotional ıntelligence in the context of phenomenology and Cartesian dualism
Authors: Canbul Yaroğlu Aslıhan 
Published: February 2025

Purpose
The purpose of this article is to deepen understanding of how emotional intelligence (EI) and artificial intelligence (AI) affect organizational behavior from a phenomenological perspective. Through philosophical lenses – particularly Descartes, Husserl and Merleau-Ponty – it highlights the contrasts and similarities between these forms of intelligence. The study aims to explore how AI and EI shape human experience and meaning-making in organizations, providing insights into how AI integration can foster more human-centered organizational practices.

Design/methodology/approach
This study employs a phenomenological approach to explore the philosophical underpinnings of EI and AI. By examining Descartes’ Cartesian dualism and Husserl’s phenomenology, the study analyzes the alignment and divergence between AI and these philosophical perspectives. The methodology integrates literature review and conceptual analysis to link philosophical insights with their organizational behavior implications, offering a framework that critically examines AI’s impact on human experience and organizational dynamics.

Findings
The findings highlight that emotional intelligence, rooted in the body-mind interaction, offers a human-centered view of experience, distinct from artificial intelligence. However, combining AI with EI can enhance organizational behavior by promoting more empathetic approaches. While AI can mimic cognitive functions, it lacks the embodied emotional experiences essential for human interaction. This insight emphasizes the need for AI systems to support, rather than disrupt, organizational meaning-making processes.

Originality/value
This article offers an original interdisciplinary perspective, merging phenomenological philosophy with organizational behavior. By examining emotional and artificial intelligence through Descartes, Husserl and Merleau-Ponty, the study presents fresh insights into AI design that prioritizes human-centered development. It contributes to AI ethics and organizational behavior literature by emphasizing the role of emotional intelligence in guiding AI integration within organizational contexts.
Aging behind bars: barriers and solutions in Norwegian correctional rehabilitation
Authors: Rocha Paulo 
Published: February 2025

Purpose
This study aims to investigate the health-related challenges faced by older inmates in Norwegian prisons, focusing on how these issues influence their ability to engage in rehabilitation programs. With an increasing proportion of inmates aged 50 and above, this research highlights the need for targeted interventions to address physical, mental and social barriers to effective rehabilitation.

Design/methodology/approach
Using a mixed-methods approach, this study explores data using statistical methods as well as analyzes quantitative survey data on inmate experiences alongside qualitative feedback to provide a comprehensive understanding of their needs. Key focus areas include infrastructure accessibility, mental health support and tailored rehabilitation initiatives.

Findings
This study reveals that while existing rehabilitation efforts improve some aspects of well-being, significant gaps remain in addressing the unique challenges faced by older inmates. These include inadequate infrastructure, limited resources for mental health care and insufficient age-appropriate programs. Recommendations emphasize the importance of policy reforms and enhanced collaboration between correctional and health-care services to develop inclusive, effective rehabilitation strategies.

Originality/value
By shedding light on the fastest-growing demographic in Norwegian prisons, this study contributes to a broader understanding of how age-specific approaches can improve rehabilitation outcomes. The findings have significant implications for corrections policy, promoting inclusivity, dignity and reduced recidivism through innovative and humane practices.
Structural evolution, phase transition and high-temperature tribological properties of Cr3C2 reinforced WC-10Co4Cr coatings by laser cladding
Authors: Ge Yuan , Xi Hui , Kong Dejun 
Published: February 2025

Purpose
The aim was to investigate the effect of Cr3C2 mass fraction the high-temperature tribological performance of laser cladded WC-10Co4Cr coating, in which the Cr3C2 played the role in enhancing wear resistance.

Design/methodology/approach
The WC-10Co4Cr-xCr3C2 (x = 5%, 10% and 15%) were prepared on H13 steel using laser cladding, and their coefficients of friction and wear rates at 500°C were investigated using a ball-on-disc wear tester.

Findings
The WC-10Co4Cr-xCr3C2 powders are composed of WC, Co3W3C, CoCr and Cr3C2 phases, and the defects such as pores and cracks are reduced by the addition of Cr3C2. The coefficient of friction and wear rats of WC-10Co4Cr-xCr3C2 coatings are decreased with the Cr3C2 mass fraction, showing that the addition of Cr3C2 significantly enhances the tribological properties of WC-10Co4Cr coating. The wear mechanism is adhesive wear and oxidation wear, and the Cr3C2 plays the roles of friction reduction and wear resistance, which provides valuable insights into optimizing the performance of WC-10Co4Cr coating.

Originality/value
The Cr3C2 was first added into the laser cladded WC-10Co4Cr coating, which improved its high-temperature tribological performance.

Peer review
The peer review history for this article is available at: https://publons.com/publon/10.1108/ILT-12-2024-0471/
Future-proofing your workforce: upskilling and reskilling as HR’s top priorities
Authors: Asiedu Esther , Tenakwah Emmanuel Senior 
Published: February 2025

Purpose
This paper aims to examine the need for continuous upskilling and reskilling as core components of organisational strategy, analysing how proactive workforce development programs can future-proof talent pipelines.

Design/methodology/approach
It draws on recent research and industry case studies to develop a framework for implementing successful upskilling and reskilling programs.

Findings
The paper shows that companies implementing skills transformation strategies can outperform their competitors. Success factors include data-driven workforce planning, modern learning technologies and growth-oriented organisational culture. The findings suggest that Chief Human Resources Officers must reposition skills development from tactical training initiatives to strategic investment priorities to ensure sustainable competitive advantage in an increasingly dynamic business environment.

Originality/value
The paper provides a framework for building effective upskilling and reskilling programs, emphasising the role of data-driven workforce planning, modern learning technologies and growth-oriented organisational culture. It offers practical insights for HR leaders on implementing data-driven workforce planning, leveraging modern learning technologies and cultivating growth-oriented organisational cultures.