bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pancreatic cancer, depression, and spirituality in therapy: “Unio Mystica” and “Achrayut,” 2 case reports
Authors: Ganguly Amvrine , Bengtsen Erik 
Published: June 2023

AbstractObjectivesPancreatic cancer is a major site of gastrointestinal tumors and remains a leading cause of cancer death in adults in the United States. There is also a strong association between pancreatic cancer and depression. When struggling with cancer, along the different phases of illness, a human being is confronted with manifold issues, which might profoundly interfere with their sense of meaning and purpose.MethodsFrom this standpoint, several different therapeutic techniques have been designed to manage the psychological needs of the patients. Here we provide 2 clinical scenarios, where there was a strong religious correlation to the therapeutic techniques employed with patients suffering from pancreatic cancer.ResultsThe 2 cases described showed some improvement in their overall life view and could recalibrate their expectations based on a strong religious foundation.Significance of resultsThe role of religion and spirituality in health has also received increasing attention in literature. Religion and spirituality can help patients with cancer find meaning in their illness, provide comfort in the face of existential fears, and receive support from a community of like-minded individuals. In effect, they also provide evidence toward the scope of and integrating the domain of spirituality into holistic cancer care.
Gender and LGBT Affinity: The Case of Ontario Premier Kathleen Wynne
Authors: Albaugh Quinn M. , Baisley Elizabeth 
Published: June 2023

AbstractWhen a party selects an out lesbian as its leader, do women and LGBT people evaluate that leader more positively? And do they become more likely to vote for that party? We answer these questions using the case of Kathleen Wynne, premier of Ontario, Canada, from 2013 to 2018. We draw on four large-sample surveys conducted by Ipsos before and after the 2011 and 2014 Ontario elections. We compare shifts in best premier choice and vote choice among non-LGBT men, non-LGBT women, LGBT men, and LGBT women from 2011 to 2014. We find gender and LGBT affinity in leader evaluations. However, we find that only non-LGBT women and LGBT men were more likely to vote Liberal after Wynne became leader. This article contributes to research on affinity by examining LGBT affinity in a real-world election and the intersection of gender and LGBT affinity.
Magnetotelluric Imaging of the Lithospheric Structure of the Southern Oklahoma Aulacogen: Evidence for Long‐Term Weakening Caused by Rifting
Authors: Chase B. F. W. , Unsworth M. J. , Atekwana E. A. , Evans R. L. , Zhu J. 
Published: June 2023

AbstractMagnetotelluric data were used to study the lithosphere structure of the Southern Oklahoma Aulacogen (SOA). Inversion of the data revealed two low resistivity anomalies beneath the SOA. The first is located in the depth range 0–90 km in the crust and upper lithospheric mantle. The second extends from a depth 100 km to the base of the lithospheric mantle and extends away from the SOA to the ends of the profile. The cause of low resistivity anomalies is discussed in relation to the tectonic evolution of the region and recent laboratory experiments on rock conductivity. The first anomaly is attributed to the combination of (a) water present in mantle minerals and (b) the formation of hydrous mineral phases by interactions between a plume and the lithosphere during rifting. Grain size reduction and fabric alignment from deformation during the Ancestral Rocky Mountain (ARM) orogeny may have also contributed to the low resistivity. This enrichment phase may have mechanically weakened the lithosphere and allowed deformation to occur during the ARM orogeny. The low resistivity of the deeper anomaly is attributed to a fluorine‐enriched phlogopite layer that is also coincident with an observed seismic mid‐lithosphere discontinuity (MLD). A lithosphere keel of mantle minerals enriched in water underlies this layer and may have formed by accretion of the plume head to the lower lithosphere after rifting, which also rethickened the lithosphere to its present‐day depths. The MLD may then reflect a melt layer along a paleo lithosphere‐asthenosphere boundary entombed during the accretion.
piRNA-1742 promotes renal cell carcinoma malignancy by regulating USP8 stability through binding to hnRNPU and thereby inhibiting MUC12 ubiquitination
Authors: Zhang Wentao , Zheng Zongtai , Wang Keyi , Mao Weipu , Li Xue , Wang Guangchun , Zhang Yuanyuan , Huang Jianhua , Zhang Ning , Wu Pengfei , Liu Ji , Zhang Haimin , Che Jianping , Peng Bo , Zheng Junhua , Li Wei , Yao Xudong 
Published: June 2023

AbstractAccumulating studies have confirmed that PIWI-interacting RNAs (piRNAs) are considered epigenetic effectors in cancer. We performed piRNA microarray expression analysis on renal cell carcinoma (RCC) tumor tissues and paired normal tissues and performed a series of in vivo and in vitro experiments to explore piRNAs associated with RCC progression and investigate their functional mechanisms. We found that piR-1742 was highly expressed in RCC tumors and that patients with high piR-1742 expression had a poor prognosis. Inhibition of piR-1742 significantly reduced tumor growth in RCC xenograft and organoid models. Mechanistically, piRNA-1742 regulates the stability of USP8 mRNA by binding directly to hnRNPU, which acts as a deubiquitinating enzyme that inhibits the ubiquitination of MUC12 and promotes the development of malignant RCC. Subsequently, nanotherapeutic systems loaded with piRNA-1742 inhibitors were found to effectively inhibit the metastasis and growth of RCC in vivo. Therefore, this study highlights the functional importance of piRNA-related ubiquitination in RCC and demonstrates the development of a related nanotherapeutic system, possibly contributing to the development of therapeutic approaches for RCC.
Direct electrification of silicon microfluidics for electric field applications
Authors: Monserrat Lopez Diego , Rottmann Philipp , Puebla-Hellmann Gabriel , Drechsler Ute , Mayor Marcel , Panke Sven , Fussenegger Martin , Lörtscher Emanuel 
Published: June 2023

AbstractMicrofluidic systems are widely used in fundamental research and industrial applications due to their unique behavior, enhanced control, and manipulation opportunities of liquids in constrained geometries. In micrometer-sized channels, electric fields are efficient mechanisms for manipulating liquids, leading to deflection, injection, poration or electrochemical modification of cells and droplets. While PDMS-based microfluidic devices are used due to their inexpensive fabrication, they are limited in terms of electrode integration. Using silicon as the channel material, microfabrication techniques can be used to create nearby electrodes. Despite the advantages that silicon provides, its opacity has prevented its usage in most important microfluidic applications that need optical access. To overcome this barrier, silicon-on-insulator technology in microfluidics is introduced to create optical viewports and channel-interfacing electrodes. More specifically, the microfluidic channel walls are directly electrified via selective, nanoscale etching to introduce insulation segments inside the silicon device layer, thereby achieving the most homogeneous electric field distributions and lowest operation voltages feasible across microfluidic channels. These ideal electrostatic conditions enable a drastic energy reduction, as effectively shown via picoinjection and fluorescence-activated droplet sorting applications at voltages below 6 and 15 V, respectively, facilitating low-voltage electric field applications in next-generation microfluidics.
Age and sex associate with outcome in older AML and high risk MDS patients treated with 10-day decitabine
Authors: Hilberink Jacobien R. , van Zeventer Isabelle A. , Chitu Dana A. , Pabst Thomas , Klein Saskia K. , Stussi Georg , Griskevicius Laimonas , Valk Peter J. M. , Cloos Jacqueline , van de Loosdrecht Arjan A. , Breems Dimitri , van Lammeren-Venema Danielle , Boersma Rinske , Jongen-Lavrencic Mojca , Fehr Martin , Hoogendoorn Mels , Manz Markus G. , Söhne Maaike , van Marwijk Kooy Rien , Deeren Dries , van der Poel Marjolein W. M. , Legdeur Marie Cecile , Tick Lidwine , Chalandon Yves , Ammatuna Emanuele , Blum Sabine , Löwenberg Bob , Ossenkoppele Gert J. ,   Dutch-Belgian Hemato-Oncology Cooperative Group (HOVON), Chitu D. A. , Klein S. K. , Griskevicius L. , Valk P. J. M. , Cloos J. , van de Loosdrecht A. A. , Breems D. , van Lammeren-Venema D. , Boersma R. , Jongen-Lavrencic M. , Söhne M. , van Marwijk Kooy R. , Deeren D. , van der Poel M. W. M. , Legdeur M. C. , Tick L. , Ammatuna E. , Löwenberg B. , Ossenkoppele G. J. , Huls G. ,   Swiss Group for Clinical Cancer Research (SAKK), Pabst T. , Stussi G. , Fehr M. , Manz M. G. , Chalandon Y. , Blum S. , Huls Gerwin 
Published: June 2023

AbstractTreatment choice according to the individual conditions remains challenging, particularly in older patients with acute myeloid leukemia (AML) and high risk myelodysplastic syndrome (MDS). The impact of performance status, comorbidities, and physical functioning on survival is not well defined for patients treated with hypomethylating agents. Here we describe the impact of performance status (14% ECOG performance status 2), comorbidity (40% HCT-comorbidity index ≥ 2), and physical functioning (41% short physical performance battery < 9 and 17% ADL index < 6) on overall survival (OS) in 115 older patients (age ≥ 66 years) treated on a clinical trial with a 10-day decitabine schedule. None of the patient-related variables showed a significant association with OS. Multivariable analysis revealed that age > 76 years was significantly associated with reduced OS (HR 1.58; p = 0.043) and female sex was associated with superior OS (HR 0.62; p = 0.06). We further compared the genetic profiles of these subgroups. This revealed comparable mutational profiles in patients younger and older than 76 years, but, interestingly, revealed significantly more prevalent mutated ASXL1, STAG2, and U2AF1 in male compared to female patients. In this cohort of older patients treated with decitabine age and sex, but not comorbidities, physical functioning or cytogenetic risk were associated with overall survival.
Germline de novo mutations in families with Mendelian cancer syndromes caused by defects in DNA repair
Authors: Sherwood Kitty , Ward Joseph C. , Soriano Ignacio , Martin Lynn , Campbell Archie , Rahbari Raheleh , Kafetzopoulos Ioannis , Sproul Duncan , Green Andrew , Sampson Julian R. , Donaldson Alan , Ong Kai-Ren , Heinimann Karl , Nielsen Maartje , Thomas Huw , Latchford Andrew , Palles Claire , Tomlinson Ian 
Published: June 2023

AbstractDNA repair defects underlie many cancer syndromes. We tested whether de novo germline mutations (DNMs) are increased in families with germline defects in polymerase proofreading or base excision repair. A parent with a single germline POLE or POLD1 mutation, or biallelic MUTYH mutations, had 3-4 fold increased DNMs over sex-matched controls. POLE had the largest effect. The DNMs carried mutational signatures of the appropriate DNA repair deficiency. No DNM increase occurred in offspring of MUTYH heterozygous parents. Parental DNA repair defects caused about 20–150 DNMs per child, additional to the ~60 found in controls, but almost all extra DNMs occurred in non-coding regions. No increase in post-zygotic mutations was detected, excepting a child with bi-allelic MUTYH mutations who was excluded from the main analysis; she had received chemotherapy and may have undergone oligoclonal haematopoiesis. Inherited DNA repair defects associated with base pair-level mutations increase DNMs, but phenotypic consequences appear unlikely.
Charge density wave induced nodal lines in LaTe3
Authors: Sarkar Shuvam , Bhattacharya Joydipto , Sadhukhan Pampa , Curcio Davide , Dutt Rajeev , Singh Vipin Kumar , Bianchi Marco , Pariari Arnab , Roy Shubhankar , Mandal Prabhat , Das Tanmoy , Hofmann Philip , Chakrabarti Aparna , Roy Barman Sudipta 
Published: June 2023

AbstractLaTe3 is a non-centrosymmetric material with time reversal symmetry, where the charge density wave is hosted by the Te bilayers. Here, we show that LaTe3 hosts a Kramers nodal line—a twofold degenerate nodal line connecting time reversal-invariant momenta. We use angle-resolved photoemission spectroscopy, density functional theory with an experimentally reported modulated structure, effective band structures calculated by band unfolding, and symmetry arguments to reveal the Kramers nodal line. Furthermore, calculations confirm that the nodal line imposes gapless crossings between the bilayer-split charge density wave-induced shadow bands and the main bands. In excellent agreement with the calculations, spectroscopic data confirm the presence of the Kramers nodal line and show that the crossings traverse the Fermi level. Furthermore, spinless nodal lines—completely gapped out by spin-orbit coupling—are formed by the linear crossings of the shadow and main bands with a high Fermi velocity.
Inflammatory cytokines and chemokines in obese adolescents with antibody against to adenovirus 36
Authors: Sanches Marcelo D’Alessandre , Goldberg Tamara Beres Lederer , Rizzo Anapaula da Conceição Bisi , da Silva Valéria Nóbrega , Mosca Luciana Nunes , Romagnoli Graziela Gorete , Gorgulho Carolina Mendonça , Araujo Junior João Pessoa , de Lima Gustavo Ramos , Betti Isabella Rodrigues , Kurokawa Cilmery Suemi 
Published: June 2023

AbstractObesity in adolescents has reached epidemic proportions and is associated with the inflammatory response and viral infections. The aim of this study was to understand the profile of inflammatory cytokines and chemokines associated with the inflammatory response and metabolic syndrome (MetS) in obese adolescents with positive serology for adenovirus 36 (ADV36). Thirty-six overweight, 36 obese, and 25 severe obesity adolescents aged 10 to 16 years were included in the study. The following variables were analyzed: sex, age, body mass index (BMI), blood pressure, total cholesterol and fractions, triglycerides, glucose, serum cytokine concentrations, and ADV36 antibodies. Cytokines and chemokines were quantified by cytometry and ADV36 serology was determined by enzyme-linked immunosorbent assay (ELISA). The results showed higher levels of the cytokines interleukin-1beta (IL-1β), IL-6, IL-10 and of the chemokine interferon-gamma-inducible protein 10 (IP-10) in severe obesity adolescents compared to the obese and overweight groups, as well as in the group with MetS compared to the group without this syndrome. The frequency of ADV36-positive individuals did not differ between groups. The findings revealed differences in BMI between the obese and severe obesity groups versus the overweight group in the presence of positivity for ADV36, suggesting an association with weight gain and possibly MetS installation.
The chromosome-scale genome assembly of cluster bean provides molecular insight into edible gum (galactomannan) biosynthesis family genes
Authors: Gaikwad Kishor , Ramakrishna Goriparthi , Srivastava Harsha , Saxena Swati , Kaila Tanvi , Tyagi Anshika , Sharma Priya , Sharma Sandhya , Sharma R. , Mahla H. R. , Kumar Kuldeep , SV Amitha Mithra , Solanke Amolkumar U. , Kalia Pritam , Rao A. R. , Rai Anil , Sharma T. R. , Singh N. K. 
Published: June 2023

AbstractCluster bean (Cyamopsis tetragonoloba (L.) Taub 2n = 14, is commonly known as Guar. Apart from being a vegetable crop, it is an abundant source of a natural hetero-polysaccharide called guar gum or galactomannan. Here, we are reporting a chromosome-scale reference genome assembly of a popular cluster bean cultivar RGC-936, by combining sequencing data from Illumina, 10X Genomics, Oxford Nanopore technologies. An initial assembly of 1580 scaffolds with an N50 value of 7.12 Mb was generated and these scaffolds were anchored to a high density SNP linkage map. Finally, a genome assembly of 550.31 Mb (94% of the estimated genome size of ~ 580 Mb (through flow cytometry) with 58 scaffolds was obtained, including 7 super scaffolds with a very high N50 value of 78.27 Mb. Phylogenetic analysis using single copy orthologs among 12 angiosperms showed that cluster bean shared a common ancestor with other legumes 80.6 MYA. No evidence of recent whole genome duplication event in cluster bean was found in our analysis. Further comparative transcriptomics analyses revealed pod-specific up-regulation of genes encoding enzymes involved in galactomannan biosynthesis. The high-quality chromosome-scale cluster bean genome assembly will facilitate understanding of the molecular basis of galactomannan biosynthesis and aid in genomics-assisted improvement of cluster bean.
Process optimization in poultry feed mill
Authors: Amin Sameh A. Salaheldein , Sobhi Nahed 
Published: June 2023

AbstractThe poultry feed industry is pretty much active in a lot of countries and it is achieved market acceptance. The final products are supposed to meet certain specifications to fulfill the nutritional need of animals at different life periods. The final product for poultry is shipped in the form of pelleted feed for the convenience of consumption. One of the major challenges of poultry feed production is the principal complement of equipment necessary for the local production. Imported poultry pellets are quite expensive and unaffordable for many poultry feed industries. Hence, the need to be able to produce poultry feed at lower cost yet achieve the objective of quantity and quality expected of pelleted feeds is critical to the viability of the enterprise. The study aims to investigate the effects of some operating parameters (pressure and temperature of the compounded feed) and die hole size on the pelleting efficiency, throughput capacity, and to optimize the conditions. The improvement approach is conducted by observing the main operating parameters of productivity; statistical analysis is conducted to observe the effect of those parameters on the production rate and the quality of the product. Comparison between parameter levels is done through analysis of variance to determine the significance of the tested parameters. The optimization of parameters was applied with Minitab and designed expert software to determine the best operating conditions. The obtained results showed that the downtime decreased by 77% monthly and productivity increased by 32.5% per hour and the pellet durability index increased by 1.23%. The total sales increased by 6,750,600 LE/Month.
Fundus autofluorescence imaging using red excitation light
Authors: Birtel Johannes , Bauer Tobias , Pauleikhoff Laurenz , Rüber Theodor , Gliem Martin , Charbel Issa Peter 
Published: June 2023

AbstractRetinal disease accounts significantly for visual impairment and blindness. An important role in the pathophysiology of retinal disease and aging is attributed to lipofuscin, a complex of fluorescent metabolites. Fundus autofluorescence (AF) imaging allows non-invasive mapping of lipofuscin and is a key technology to diagnose and monitor retinal disease. However, currently used short-wavelength (SW) excitation light has several limitations, including glare and discomfort during image acquisition, reduced image quality in case of lens opacities, limited visualization of the central retina, and potential retinal light toxicity. Here, we establish a novel imaging modality which uses red excitation light (R-AF) and overcomes these drawbacks. R-AF images are high-quality, high-contrast fundus images and image interpretation may build on clinical experience due to similar appearance of pathology as on SW-AF images. Additionally, R-AF images may uncover disease features that previously remained undetected. The R-AF signal increases with higher abundance of lipofuscin and does not depend on photopigment bleaching or on the amount of macular pigment. Improved patient comfort, limited effect of cataract on image quality, and lack of safety concerns qualify R-AF for routine clinical monitoring, e.g. for patients with age-related macular degeneration, Stargardt disease, or for quantitative analysis of AF signal intensity.
Phase retrieval from single interferogram without carrier using Lissajous ellipse fitting technology
Authors: Liu Fengwei , Kuang Yu , Wu Yongqian , Chen Xiaojun , Zhang Rongzhu 
Published: June 2023

AbstractPhase extraction from single interferogram is of high significance and increasingly interest in optical metrology. In this contribute we propose an advanced Pixel-level Lissajous Ellipse Fitting (APLEF) method to extract the phase from single interferogram without carrier. At each pixel, a Lissajous figure is created by plottingNagainstD, whereNandDare subtractions and additions of intensities of adjacent pixels in a small window. The so created Lissajous figure is already in phase quadrature because of the subtraction and addition process, and the Lissajous Figure is forced to be closed by taking the opposite values ofNandD,i.e.–Nand-Dinto account. The closed and in phase quadrature Lissajous Figure is the key point for APLEF to demodulate the single inteferogram without carrier in theoretically. The simulation shows its higher accuracy than existed SPT and Garbusi’s method and the experiments finally corroborate its effectiveness.
Synthesis and antimicrobial activity of new series of thiazoles, pyridines and pyrazoles based on coumarin moiety
Authors: Sayed Mariam T. , Elsharabasy Salwa A. , Abdel-Aziem Anhar 
Published: June 2023

AbstractMicrobial infections are currently a widespread disease in hospitals and community health centres and are a major cause of death worldwide. In pursuit of searching new antimicrobial agents, coumarin linked to thiazoles, pyridines and pyrazoles have been developed and evaluated for their antimicrobial properties against two Gram + bacteria, two Gram − bacteria as well as two fungi. Some of the prepared coumarins displayed high to moderate activity against the tested microorganisms with respect to the reference drugs. However, compound 3 exhibited antimicrobial effect equal to the reference drug Ciprofloxacin for Gram − baceria Enterobacter cloacae. Compound 12 was found to be the most potent compound against Bacillus pumilis with MIC of 7.69 (µmol/ml). Compounds 3, 4 and 12 showed remarkable activity against Streptococcus faecalis with MIC of 14.34, 3.67 and 15.36 (µmol/ml), respectively. Regarding Escherichia coli, most compounds recorded high to moderate MIC values (4.73–45.46 µmol/ml). Moreover, in case of E. cloacae compound 9 was the most potent compound with MIC value of 22.76 (µmol/ml).