bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of the diagnostic ability of oral lesions on clinical images among undergraduate dental students
Authors: Antoranz‐Pereda Ana , de Pedro Miguel , Navarrete Natalia , Vizoso‐Noval Beatriz , Cidoncha‐Cabrerizo Gema , Pérez Ruth , Casañas Elisabeth , Muñoz‐Corcuera Marta 
Published: March 2023

AbstractIntroductionThe dentist should be able to carry out systematic oral examinations of the mucosa of patients in order to diagnose any alterations at an early stage.Materials and MethodsAn observational, analytical, prospective, and longitudinal study was carried out. 161 students were evaluated at the beginning of their clinical practice in their 4th year of dental school (September 2019), at the beginning and at the end of their 5th year of dental school (June 2021). Thirty oral lesions were projected, and the students were asked to provide an answer; if the lesions were benign, malignant, or potentially malignant, whether they should be biopsied and/or treated and a presumptive diagnosis.ResultsSignificant improvement (p < .001) was obtained between the 2019 and 2021 results, in relation to the classification, need for biopsy and treatment of lesions. For differential diagnosis, no significant difference (p = .985) was obtained between the 2019 and 2021 responses. Malignant lesions and PMD obtained mixed results, with the best results corresponding to OSCC.DiscussionIn this study, a correct lesion classification by the students was over 50%. As for the OSCC, the results were superior to the rest of the images, reaching more than 95% correct.ConclusionTheoretical‐practical training from universities and continuing education for graduates in relation to oral mucosal pathologies should be further promoted.
Digital Module 31: Testing Accommodations for Students with Disabilities
Authors: Lovett Benjamin J. 
Published: March 2023

AbstractStudents with disabilities often take tests under different conditions than their peers do. Testing accommodations, which involve changes to test administration that maintain test content, include extending time limits, presenting written text through auditory means, and taking a test in a private room with fewer distractions. For some students with disabilities, accommodations such as these are necessary for fair assessment; without accommodations, invalid interpretations would be made on the basis of these students’ scores. However, when misapplied, accommodations can also diminish fairness, introduce new sources of construct‐irrelevant variance, and also lead to invalid interpretation of test scores. This module provides a psychometric framework for thinking about accommodations, and then explicates an accommodations decision‐making framework that includes a variety of considerations. Problems with current accommodations practices are discussed, along with potential solutions and future directions. The module is accompanied by exercises allowing participants to apply their understanding.
Fundus imaging and perimetry in patients with idiopathic intracranial hypertension—an intermethod and interrater validity study
Authors: Rissan Zainab , Hansen Nadja Skadkær , Carlsen Louise Ninett , Korsbæk Johanne Juhl , Jensen Rigmor Højland , Hamann Steffen , Schytz Henrik Winther 
Published: March 2023

AbstractBackground and purposeThere is a need to improve the diagnostic process of patients suspected of papilledema. In patients with known or suspected idiopathic intracranial hypertension a fundus imaging and perimetric visual field assessment system (COMPASS) performed at a headache center was validated in comparison to an assessment (Topcon plus OCTOPUS) at a neuroophthalmological clinic.MethodsFor intermethod assessment, blinded fundus images and perimetry from COMPASS versus Topcon plus OCTOPUS were assessed by a neuroophthalmologist. For interrater assessment, fundus images and perimetry obtained by the COMPASS system were assessed by an untrained medical doctor, a trained neurologist and a trained medical student and compared to the neuroophthalmologist's assessments.ResultsFor the intermethod variation of the presence of papilledema on fundus images, a kappa value of 0.60, sensitivity of 87% and specificity of 73% were found. The interrater variation of the presence of papilledema on fundus images showed kappa values ranging from 0.43 to 0.74, sensitivity values ranging from 70% to 96% and specificity values ranging from 46% to 93% when comparing the assessments made by the headache center staff with neuroophthalmologist's assessments. The COMPASS showed a 59% sensitivity and moderate agreement in detecting visual field defects compared with OCTOPUS. The visual field assessment showed only slight to fair agreement from 0.19 to 0.31 between assessments made by the headache center staff and the neuroophthalmologist.ConclusionThe COMPASS system can be used with reasonable sensitivity in the assessment of papilledema in patients suspected of idiopathic intracranial hypertension at a tertiary headache center.
TRPS1 expression is sensitive and specific for primary extramammary Paget disease
Authors: Cook Eleanor E , Harrison Beth T , Hirsch Michelle S 
Published: March 2023

AimsExtramammary Paget disease (EMPD) is an epithelial neoplasm that can occur at many sites, including the vulva and scrotum. EMPD is characterised by the presence of neoplastic cells, in single cells and clusters, that infiltrate all layers of non‐neoplastic squamous epithelium. The differential diagnosis for EMPD includes melanoma in situ and secondary involvement of tumours from other sites, such as urothelial or cervical; pagetoid spread of tumor cells can also been seen at other sites, such as anorectal mucosa. The most frequently utilised biomarkers for confirming the diagnosis of EMPD include CK7 and GATA3; however, these biomarkers lack specificity. The purpose of this study was to evaluate TRPS1, a newly described breast biomarker, in pagetoid neoplasms of the vulva, scrotum and anorectum.Methods and resultsFifteen cases of primary EMPD of the vulva (two with associated invasive carcinoma) and four primary EMPD of the scrotum showed strong nuclear immunoreactivity for TRPS1. In contrast, five cases of vulvar melanoma in situ, one case of urothelial carcinoma with secondary pagetoid spread into the vulva and two anorectal adenocarcinomas with pagetoid spread into anal skin (one with associated invasive carcinoma) were negative for TRPS1. Additionally, weak nuclear TRPS1 staining was observed in non‐neoplastic tissues (e.g. keratinocytes), but always with less intensity when compared to tumour cells.ConclusionsThese results demonstrate that TRPS1 is a sensitive and specific biomarker for EMPD, and may be especially useful for excluding secondary involvement of the vulva by urothelial and anorectal carcinomas.
Risk factors for incisional complications after lumbar internal fixation via posterior midline approach: A case‐control study of 455 consecutive cases
Authors: Cao Le , Sun Kai , Yang Haitao , Zeng Ran , Wang Hongyi 
Published: March 2023

AbstractTo analyse the clinical data of patients who developed incisional complications and those who did not develop incisional complications after lumbar internal fixation, and investigate the risk factors for incisional complications in patients after lumbar internal fixation with posterior midline incision. A standardised data collection form was used to collect the clinical data of patients who were admitted and underwent lumbar internal fixation in our hospital from July 2018 to July 2021. Patients who experienced any one of the incisional complications, such as incision exudates, swelling, blisters, bruising, superficial/deep incisional infections, poor healing and scarring, after surgery were included in the incisional complication group, and patients who did not develop the above‐mentioned incisional complications were included in the control group. Univariate logistic regression analysis was first performed to identify potential risk factors, significant factors from univariate analysis were then included in multivariable logistic regression analysis to identify independent risk factors for incisional complications after lumbar spine surgery. Among 455 patients included in the study, postoperative incision complications occurred in 82 patients, with an incidence rate of 18.02%. Multivariate regression analysis identified seven independent risk factors for incisional complications: age, body mass index, preoperative albumin level, hypertension, diabetes mellitus, operation time and local anaesthetic infiltration at the incision site after surgery. Our findings documented that age, body mass index, preoperative albumin level, hypertension, diabetes mellitus, operation time, and postoperative local anaesthetic infiltration at the incision site were risk factors for incisional complications after lumbar internal fixation with posterior median incision. Awareness of these risk factors can enable surgeons to develop a more appropriate perioperative management plan for patients undergoing lumbar internal fixation, thus helping them recover faster.
Hispolon induces apoptosis in oral squamous cell carcinoma cells through JNK/HO‐1 pathway activation
Authors: Yang Wei‐En , Chen Yi‐Tzu , Su Chun‐Wen , Chen Mu‐Kuan , Yeh Chia‐Ming , Chen Yen‐Lin , Tsai Meng‐Ying , Yang Shun‐Fa , Lin Chiao‐Wen 
Published: March 2023

AbstractOral squamous cell carcinoma (OSCC) has a high recurrence rate and poor prognosis. Hispolon, a polyphenolic compound with antiviral, antioxidant, and anticancer activities, is a potential chemotherapy agent. However, few studies have investigated the anti‐cancer mechanism of hispolon in oral cancer. This present study used the cell viability assay, clonogenic assay, fluorescent nuclear staining, and flow cytometry assay to analyse the apoptosis‐inducing effects of hispolon in OSCC cells. After hispolon treatment, the apoptotic initiators, cleaved caspase‐3, −8, and − 9, were upregulated, whereas the cellular inhibitor of apoptosis protein‐1 (cIAP1) was downregulated. Furthermore, a proteome profile analysis using a human apoptosis array revealed the overexpression of heme oxygenase‐1 (HO‐1) by hispolon, which was determined to be involved in caspase‐dependent apoptosis. Moreover, cotreatment with hispolon and mitogen‐activated protein kinase (MAPK) inhibitors revealed that hispolon induces apoptosis in OSCC cells through activation of the c‐Jun N‐terminal kinase (JNK) pathway and not the extracellular signal‐regulated kinase (ERK) or p38 pathway. These findings indicate that hispolon may exert an anticancer effect on oral cancer cells by upregulating HO‐1 and inducing caspase‐dependent apoptosis by activating the JNK pathway.
cLFM‐Qol: A specific quality of life measurement tool for children from 11 to 15 years with low‐flow malformations
Authors: Godeau Marion , Shourick Jason , Dreyfus Isabelle , Casassa Éline , Bergeron Anaïs , Severino‐Freire Maella , Granier Tournier Céline , Malloizel‐Delaunay Julie , Boccara Olivia , Aubert Hélène , Maruani Annabel , Chiaverini Christine , Labrèze Christine , Mazereeuw‐Hautier Juliette 
Published: March 2023

AbstractBackgroundLow‐flow malformations (LFMs) are rare diseases with a significant impact on health‐related quality of life (HRQoL), especially in children. No disease‐specific questionnaire is available for children with LFMs.ObjectiveTo develop and validate a specific HRQoL questionnaire for children from 11 to 15 years old suffering from LFMs.MethodsA preliminary questionnaire based on a verbatim from focus groups was created and sent to children from 11 to 15 years old suffering from LFMs, together with a dermatology‐specific and a generic HRQoL questionnaire (cDLQI and EQ‐5D‐Y).ResultsA total of 75 from 201 included children responded to the questionnaires. The final version of the questionnaire (cLFM‐QoL) included 15 questions and was not divisible into subscales. It demonstrated excellent internal consistency (cronbach 0.89), convergent validity and readability (SMOG 6.04). cLFM‐QoL mean score (± SD) was 12.9/45 (8.03) for all grades of severity, for mild 8.22/45 (7.5), moderate 14.03/45 (8.35), severe 12.35/45 (6.59) or very severe patients 20.7/45 (3.39) (p 0.006).ConclusioncLFM‐QoL is a validated short and easy to use specific questionnaire with excellent psychometric capacities. It will be suitable for any children aged 11–15 with LFMs, in daily practice or clinical trials.
Differences between responders and nonresponders in intensive care unit (ICU) related survey studies
Authors: Brekelmans A. C. M. , Ramnarain D. , Pouwels S. 
Published: March 2023

AbstractBackgroundIn survey research studies, there are often a proportion of non‐responders, that is patients or relatives of patients who do not want to fill in a survey. Especially in intensive care medicine, these proportions of non‐responders can be relatively high. However, with the increasing incidence of post‐intensive care syndrome (PICS), it can be beneficial to know what the predisposing factors are.MethodsWe performed a sub analysis of a recent survey study we have conducted on relatives of deceased ICU patients. Of the 219 eligible relatives, 139 were willing to fill in the questionnaires and 95 of them actually returned the questionnaire, which raises the question whether there are differences between the 95 relatives who did fill in the questionnaires and the 44 relatives who did not. We collected information from the medical records of deceased patients whose relatives did and did not fill in the questionnaires, that is responders and non‐responders.ResultsPatient's whose relatives did not fill in the questionnaire had a significantly lower median age compared with patients whose relatives returned the questionnaires (64 [56–75] vs. 71 [65–76] years, respectively, p = .039). The non‐responders were two relatives of a deceased patient below 60 years in 34.1% of the cases, whereas this percentage was 14.7% in the responders. The distribution of men and women was comparable between the groups (p = .54) as well as the length of ICU stay (p = .48).ConclusionOur findings suggest that ICU‐related variables did not influence response rate, but the age of the deceased ICU patient does: The non‐responders are related to deceased ICU patients with a significantly lower age.
Competition and Misconduct
Authors: THANASSOULIS JOHN 
Published: March 2023

ABSTRACTMisconduct is widespread. Practices such as misselling, pump and dump, and money laundering cause harm while raising profits. This paper presents a mechanism that can determine what sorts of misconduct can be sustained in competitive equilibrium in concentrated markets, oligopoly settings, and markets with many small competing firms. The model studied allows general demand and distinguishes types of ethical dilemma using current psychological understanding. The paper shows, for example, that markets with many small competing firms are not vulnerable to misconduct if firms respond to entry with niche strategies or if the ethical dilemma draws an emotional response.
Fabrication of custom oral positioning devices in head and neck proton radiotherapy
Authors: Lee Sarah Kay Youny , Bigsby Arthur , Morris Jonathan , Deisher Amanda , Mundy Daniel , Muller Olivia 
Published: March 2023

AbstractWith complex head and neck diseases that closely approximate crucial organs or have advanced spread and cannot be surgically resected, intensity modulated proton beam radiotherapy is favored due to its superior dose targeting through magnetic manipulation of the proton energy. A radiation mask and an oral positioning device immobilize craniofacial, cervical, and oral structures for accurate and reliable radiation delivery. Widely available prefabricated thermoplastic oral positioning devices are manufactured in standardized forms and materials that unpredictably affect the proton beams’ pathways and range. This technique article showcases a workflow that combines analog and digital dental techniques to produce a customized 3D‐printed oral positioning device within 2 appointments.
Animal protein‐soybean oil‐based broiler diet optimizes net profit at the expense of desirable ω‐6 fatty acids from the breast muscle of the broiler chicken
Authors: Hossain Md. Emran , Akter Nasima , Bhowmik Priunka , Islam Md. Saiful , Sultan Md. Nahid , Islam Shilpi 
Published: March 2023

AbstractTotal 288 Ross‐308‐day‐old male broiler chicks were randomly distributed into six dietary treatment groups in a two‐way ANOVA with 2 × 3 factorial arrangements (two factors, i.e., dietary protein and energy having two types of protein, e.g., plant, animal and three different sources of energy, e.g., soybean oil, rice bran oil and sunflower oil) to justify if animal protein‐soybean oil based broiler diet optimizes net profit at the expense of desirable ω‐6 fatty acids in the breast muscle of the broiler chicken. Average daily feed intake (ADFI), final live weight (FLW), average daily gain (ADG), feed efficiency (FE), carcass characteristics, cardio‐pulmonary morphometry, fatty acid profile of the breast muscle and cost‐benefit analysis were measured. Results indicated that animal protein significantly increased 4.27% FLW, 6.13% ADFI, 4.31% ADG and 2.93% wing weight. Accordingly, soybean oil increased 4.76% FLW, 3.80% ADG and 1.36% dressing percentage at the expense of 12.07% proventriculus weight compared with sunflower oil. The generalized linear model identified no interaction effects of the sources of protein and energy on overall performance of the birds. Replacement of vegetable protein by animal protein decreased 14.01% ∑ω‐3, 12.16% ∑ω‐6 and 12.21% sum of polyunsaturated fatty acids (∑PUFA) and concomitantly increased 10.82% sum of saturated fatty acids (∑SFAs) in the breast muscle (Pectoralis major). Accordingly, replacement of sunflower oil by soybean oil decreased 29.17% ∑ω‐3, 6.71% ∑ω‐6, 11.62% sum of monounsaturated fatty acids (∑MUFAs) and 7.33% ∑PUFAs and concurrently increased 18.36% ∑SFAs in the breast muscle of the broiler birds. It was concluded that animal protein‐soybean oil‐based broiler diet optimized net profit at the expense of desirable ω‐3 and ω‐6 fatty acids in the breast muscle of the broiler chicken.
Impacts on the CV parent body: A coordinated, multiscale fabric analysis of the Allende meteorite
Authors: Forman L. V. , Daly L. , Bland P. A. , Benedix G. K. , Corrigan C. 
Published: March 2023

AbstractEvidence of impact‐induced compaction in the carbonaceous chondrites, specifically CMs and CVs, has been widely investigated utilizing microscopy techniques and impact experiments. Here, we use high‐resolution photography and large area and high‐resolution electron backscattered diffraction (EBSD) mapping analyses in tandem, to explore the effects of impact‐induced compaction at both the meso‐ and micro‐scales in the Allende CV3.6 carbonaceous chondrite. Macro‐scale photography images of a ~25 cm slab of Allende captured meso‐scale features including calcium‐aluminum inclusions (CAIs) and chondrules. CAIs have a long‐axis shape‐preferred orientation (SPO). Examination of such meso‐scale features in thin section revealed the same trend. Matrix grains from this section display a large amount of heterogeneity in petrofabric orientation; microscale, high‐resolution, large area EBSD mapping of ~300,000 olivine matrix grains; high‐resolution large area EBSD map across an elongate CAI; and a series of high‐resolution EBSD maps around two chondrules and around the CAI revealed crystallographic preferred orientations (CPOs) in different directions. Finally, internal grains of the CAI were found to demonstrate a weak lineation CPO, the first crystallographic detection of possible CAI “flow.” All results are consistent with multiple, gentle impacts on the Allende parent body causing hemispheric compaction. The larger, more resistant components are likely to have been compressed and oriented by earlier impacts, and the matrix region petrofabrics and CAI “flow” likely occurred during subsequent impacts. Meteoritic components respond differently to impact events, and consequently, it is likely that different components would retain evidence of different impact events and angles.
Trends in planetary science research in the Puna and Atacama Desert regions: Underrepresentation of local scientific institutions?
Authors: Tavernier A. , Pinto G. A. , Valenzuela M. , Garcia A. , Ulloa C. , Oses R. , Foing B. H. 
Published: March 2023

AbstractIn 2019, while launching a multidisciplinary research project aimed at developing the Puna de Atacama region as a natural laboratory, investigators at the University of Atacama (Chile) conducted a bibliographic search identifying previously studied geographic points of the region and of potential interest for planetary science and astrobiology research. This preliminary work highlighted a significant absence of local institutional involvement in international publications. In light of this, a follow‐up study was conducted to confirm or refute these first impressions, by comparing the search in two bibliographic databases: Web of Science and Scopus. The results show that almost 60% of the publications based directly on data from the Puna, the Altiplano, or the Atacama Desert with objectives related to planetary science or astrobiology do not include any local institutional partner (Argentina, Bolivia, Chile, and Peru). Indeed, and beyond the ethical questioning of international collaborations, Latin‐American planetary science deserves a strategic structuring, networking, as well as a road map at national and continental scales, not only to enhance research, development, and innovation, but also to protect an exceptional natural heritage sampling extreme environmental niches on Earth. Examples of successful international collaborations such as the field of meteorites, terrestrial analogs, and space exploration in Chile or astrobiology in Mexico are given as illustrations and possible directions to follow to develop planetary science in South America. To promote appropriate scientific practices involving local researchers, possible responses at academic and institutional levels will eventually be discussed.
There's a certain slant of light: Three attitudes toward the political turn in analytic philosophy
Authors: Almagro Manuel , Guerra Sergio 
Published: March 2023

AbstractThere has been a growing interest within analytic philosophy in addressing political and social issues, which has been referred to as the “political turn” in the discipline. The aim of this paper is twofold. First, it discusses the very characterization of the political turn. In particular, it introduces the definition proposed by Bordonaba‐Plou, Fernández‐Castro, and Torices, suggests that we should not consider the turn a form of activism, and explores an additional benefit of the ideal/nonideal distinction for characterizing the turn. Second, it addresses the concern of what attitude we should take in the face of the different sensitivities we might have with respect to what constitutes an injustice. Which philosophical works should count as part of the political turn? The paper explores three different attitudes toward this dilemma, and favors what it calls the revisionist attitude, which emphasizes the fact that our perception of injustice is subject to error.