bluuebunny/crossref_metadata_2025_split huggingface dataset:
Oncogene-like addiction to aneuploidy in human cancers
Authors: Girish Vishruth , Lakhani Asad A. , Scaduto Christine M. , Thompson Sarah L. , Brown Leanne M. , Hagenson Ryan A. , Sausville Erin L. , Mendelson Brianna E. , Lukow Devon A. , Yuan Monet Lou , Kandikuppa Pranav K. , Stevens Eric C. , Lee Sophia N. , Salovska Barbora , Li Wenxue , Smith Joan C. , Taylor Alison M. , Martienssen Robert A. , Liu Yansheng , Sun Ruping , Sheltzer Jason M. 
Published: January 2023

ABSTRACTMost cancers exhibit aneuploidy, but its functional significance in tumor development is controversial. Here, we describe ReDACT (Restoring Disomy in Aneuploid cells using CRISPR Targeting), a set of chromosome engineering tools that allow us to eliminate specific aneuploidies from cancer genomes. Using ReDACT, we created a panel of isogenic cells that have or lack common aneuploidies, and we demonstrate that trisomy of chromosome 1q is required for malignant growth in cancers harboring this alteration. Mechanistically, gaining chromosome 1q increases the expression of MDM4 and suppresses TP53 signaling, and we show that TP53 mutations are mutually-exclusive with 1q aneuploidy in human cancers. Thus, specific aneuploidies play essential roles in tumorigenesis, raising the possibility that targeting these “aneuploidy addictions” could represent a novel approach for cancer treatment.
Activation of basal forebrain astrocytes induces wakefulness without compensatory changes in sleep drive
Authors: Ingiosi Ashley M. , Hayworth Christopher R. , Frank Marcos G. 
Published: January 2023

AbstractMammalian sleep is regulated by a homeostatic process that increases sleep drive and intensity as a function of prior wake time. Sleep homeostasis has traditionally been thought to be a product of neurons, but recent findings demonstrate that this process is also modulated by glial astrocytes. The precise role of astrocytes in the accumulation and discharge of sleep drive is unknown. We investigated this question by selectively activating basal forebrain (BF) astrocytes using designer receptors exclusively activated by designer drugs (DREADDs). Activation of the Gq-protein-coupled pathway in BF astrocytes produced long and continuous periods of wakefulness that paradoxically did not cause the expected homeostatic response to sleep loss (e.g., increases in sleep time or intensity). Further investigations showed that this was not due to indirect effects of the ligand that activated DREADDs. These findings suggest that the need for sleep is not driven by wakefulness per se, but specific neuronal-glial circuits that are differentially activated in wakefulness.
Weak impact of underground water on corrosion inhibition of resistance-reducing agent
Authors: Su Hui , Liu Lanlan , Yang Yang , Zhong Zhen , Xu Song , Xie Yi , Wu Tangqing 
Published: January 2023

Purpose
The purpose of this paper is to study the corrosion behavior of Q235 steel in the bentonite-based resistance-reducing agent (RRA) with different infiltration rates of underground water.

Design/methodology/approach
The corrosion behavior of the steel in underground water was assessed by weight loss experiment, electrochemical impedance spectroscopy and polarization curve.

Findings
The results showed that the corrosion rate of the steel in the RRA pastes was much lower than that in the original acidic soil. The underground water infiltration slightly accelerated the corrosion rate of the steel in the RRA pastes, but the acceleration role is weak. The bentonite-based RRA can be compatibly applied in the acidic soil.

Originality/value
The bentonite-based RRA can significantly reduce the corrosion rate of the steel and is suitable to compatibly apply in the acidic soil.
How was the coronavirus vaccine accepted on Twitter? A computational analysis using big data in Japan
Authors: Tanihara Tsukasa , Yamaguchi Shinichi 
Published: January 2023

Purpose
This study aims to reveal how the COVID-19 vaccine was accepted in the Japanese Twitter-sphere. This study explores how the topics related to the vaccine promotion project changed on Twitter and how the topics that were likely to spread changed during the vaccine promotion project.

Design/methodology/approach
The computational social science methodology was adopted. This study collected all tweets containing the word “vaccine” using the Twitter API from March to October 2021 and conducted the following analysis: analyzing frequent words and identifying topics likely to spread through the cosine similarity and Tobit model.

Findings
First, vaccine hesitancy–related words were frequently mentioned during the vaccine introduction and dissemination periods and had diffusing power only during the former period. Second, vaccine administration–related words were frequently mentioned and diffused through April to May and had diffusing power throughout the period. The background to these findings is that the sentiment of longing for vaccines outweighed that of hesitancy toward vaccines during this period.

Originality/value
This study finds that the timing of the rise in vaccine hesitation sentiment and the timing of the start of vaccine supply were misaligned. This is one of the reasons that Japan, which originally exhibited strong vaccine hesitancy, did not face vaccine hesitancy in the COVID-19 vaccine promotion project.
Digitalization and third-party logistics performance: exploring the roles of customer collaboration and government support
Authors: Zhou Haidi , Wang Qiang , Wang Liang , Zhao Xiande , Feng Gengzhong 
Published: January 2023

PurposeThe authors investigate how logistics digitalization affects two types of third-party logistics (3PL) performance: financial performance and service performance. In particular, the authors explore the mediating role of customer collaboration between logistics digitalization and firm performance based on organizational information processing theory and examine the moderating role of government support.Design/methodology/approachThe authors use an SPSS macro program (PROCESS regression analysis) to analyze survey data from 235 3PL firms in China. The mediation model, moderation model and moderated mediation model are tested.FindingsThe empirical results show that in the new age of digitalization transformation, logistics digitalization positively affects 3PL's financial performance and service performance by strengthening customer collaboration. Additionally, government support amplifies the positive effect of customer collaboration on service performance but not financial performance. The moderated mediation test further indicates that government support strengthens the positive indirect effect of digitalization on service performance through customer collaboration.Originality/valueThis study offers empirical insights into the growing body of 3PL literature, and the findings contribute to the theoretical and practical understanding of the emerging research topic of digital transformation (DT) and sustainability issues in 3PL firms.
Species composition, abundance and habitat association of non‐volant small mammals in Gibe Sheleko National Park, southwestern Ethiopia
Authors: Kiros Seyoum , Bekele Afework 
Published: January 2023

AbstractThe objective of this study was to assess the species composition, abundance and habitat association of non‐volant small mammals from grassland, Acacia woodland, farmland, riverine forest, bushland and wooded grassland habitats in Gibe Sheleko National Park, southwestern Ethiopia. Data were collected using 49 Sherman live traps in 70 × 70 m sized girds and visual observations from December 2018 to August 2020. A total of 937 small mammals belonging to 10 species were captured and directly identified. The identified small mammal species and their relative abundance include Arvicanthis niloticus (7.04%), Crocidura olivieri (1.92%), Grammomys dolichurus (3.84%), Lemniscomys striatus (10.25%), Mastomys awashensis (24.55%), Mastomys natalensis (33.83%), Mus tenellus (0.85%), Myomys fumatus (6.30%), Rattus rattus (4.70%) and Stenocephalemys albipes (6.72%). Hystrix cristata, Xerus rutilus and Tachyoryctes splendens were documented through observation. The highest number of species (6) was registered at farmland and wooded grassland followed by bushland and riverine forest (5) and Acacia woodland and grassland (4). Lemniscomys striatus, M. awashensis and M. natalensis were common in all habitats. More, 216 (23.05%) individuals were recorded in farmland, while the least, 111 (11.85%) were recorded in Acacia woodland. The study area has various topographical land settings additional study is needed using different traps.
A review of the ecological knowledge on the species Batrachoides liberiensis in estuarine and lagoon environments of West Africa
Authors: Simier Monique , Sadio Oumar , Tito de Morais Luis , Ecoutin Jean‐Marc 
Published: January 2023

AbstractScientific fishing programmes were carried out between 1979 and 2013 in several West African estuarine, coastal and lagoon ecosystems. Batrachoides liberiensis represented only 5.2% of the occurrences, of which the majority were recorded in the Sine Saloum estuary. This originality makes it possible to use this population to characterise certain features of the biology and ecology of this little described species. B. liberiensis was recorded in waters with a salinity of 25–46, transparency of 1–3.5 m, at depths of 2–10 m. It was particularly abundant in areas at a distance of 15–35 km from the mouth. The water temperature did not appear to be a determining factor for this species. The sex ratio of the population, whose total length ranged from 10 to 371 mm, was in favour of females (87%) with an estimated size at first maturity of 189 mm (total length). The parameters of the length‐weight relationship were estimated at K = 1.0009*10−5 and b = 3.097. The diet of B. liberiensis consisted mainly of molluscs and crabs, present in respectively, 53.6% and 50.7% of the stomach contents analysed.
Intermitochondrial cement (IMC) harbors piRNA biogenesis machinery and exonuclease domain‐containing proteins EXD1 and EXD2 in mouse spermatocytes
Authors: Olotu Opeyemi , Dowling Mark , Homolka David , Wojtas Magdalena N. , Tran Panyi , Lehtiniemi Tiina , Da Ros Matteo , Pillai Ramesh S. , Kotaja Noora 
Published: January 2023

AbstractBackgroundGerm granules are large cytoplasmic ribonucleoprotein complexes that emerge in the germline to participate in RNA regulation. The two most prominent germ granules are the intermitochondrial cement (IMC) in meiotic spermatocytes and the chromatoid body (CB) in haploid round spermatids, both functionally linked to the PIWI‐interacting RNA (piRNA) pathway.AimsIn this study, we clarified the IMC function by identifying proteins that form complexes with a well‐known IMC protein PIWIL2/MILI in the mouse testis.ResultsThe PIWIL2 interactome included several proteins with known functions in piRNA biogenesis. We further characterized the expression and localization of two of the identified proteins, Exonuclease 3′–5′ domain‐containing proteins EXD1 and EXD2, and confirmed their localization to the IMC. We showed that EXD2 interacts with PIWIL2, and that the mutation of Exd2 exonuclease domain in mice induces misregulation of piRNA levels originating from specific pachytene piRNA clusters, but does not disrupt male fertility.ConclusionAltogether, this study highlights the central role of the IMC as a platform for piRNA biogenesis, and suggests that EXD1 and EXD2 function in the IMC‐mediated RNA regulation in postnatal male germ cells.
Carbohydrate‐rich diet increases critical thermal maximum in ants
Authors: Freires Allana Sabrina Alves , Ferreira Carlos André Souza , Nascimento Geraldo , Arnan Xavier 
Published: January 2023

AbstractTo understand species’ responses to climate change, we must better comprehend the factors shaping physiological critical thermal limits. One factor of potential importance is nutrient availability. Carbohydrates are an energy source that can directly affect an organism's physiological state. Ants are among the most omnipresent and ecologically relevant animal groups on Earth, and many ant species consume carbohydrate‐based diets. Additionally, as ectotherms, ants are highly vulnerable to the effects of climate change. Here, we examined the relationship between foraging temperature, carbohydrate availability, and critical thermal maximum (CTmax) in ants (Hymenoptera: Formicidae). First, we conducted a laboratory experiment using 3–4 colonies of two species that forage at high temperatures (Camponotus blandus Smith and Dorymyrmex thoracicus Gallardo) and two species that forage at lower temperatures (Nylanderia fulva Mayr and Dolichoderus quadridenticulatus Roger). Each colony was divided into two experimental subcolonies, which were given diets containing different carbohydrate concentrations (5 vs. 20% sucrose solutions). We then measured CTmax. We also collected ants belonging to these species in the field and measured their CTmax. We found that CTmax was highest for the two species that forage at higher temperatures. For C. blandus and D. thoracicus, workers given 20% sucrose had higher CTmax than workers given 5% sucrose. No diet‐mediated differences in CTmax were seen for N. fulva and D. quadridenticulatus workers. Additionally, the experimental ants in both treatment groups had higher CTmax than their field‐collected conspecifics, except in the case of C. blandus. If carbohydrate‐rich diets can boost heat tolerance in some species, it is possible that changes in resource availability could determine how climate change affects ants, especially species with carbohydrate‐based diets. Furthermore, these impacts could ripple across the entire trophic network.
A cross‐sectional investigation of cognition and epileptiform discharges in juvenile absence epilepsy
Authors: Dharan Anita L. , Bowden Stephen C. , Peterson Andre , Lai Alan , Seneviratne Udaya , Dabscheck Gabriel , Nurse Ewan , Loughman Amy , Parsons Nicholas , D'Souza Wendyl J. 
Published: January 2023

AbstractObjectivesDespite the prevalence of cognitive symptoms in the idiopathic generalized epilepsies (IGEs), cognitive dysfunction in juvenile absence epilepsy (JAE), a common yet understudied IGE subtype, remains poorly understood. This descriptive study provides a novel, comprehensive characterization of cognitive functioning in a JAE sample and examines the relationship between cognition and 24‐h epileptiform discharge load.MethodForty‐four individuals diagnosed with JAE underwent cognitive assessment using Woodcock Johnson III Test of Cognitive Abilities with concurrent 24‐h ambulatory EEG monitoring. Generalized epileptiform discharges of any length, and prolonged generalized discharges ≥3 s were quantified across wakefulness and sleep. The relationship between standardized cognitive scores and epileptiform discharges was assessed through regression models.ResultsCognitive performances in overall intellectual ability, acquired comprehension‐knowledge, processing speed, long‐term memory storage and retrieval, and executive processes were 0.63–1.07 standard deviation (SD) units lower in the JAE group compared to the population reference mean, adjusted for educational attainment. Prolonged discharges (≥3 s) were recorded in 20 patients (47.6%) from 42 available electroencephalography (EEG) studies and were largely unreported. Duration and number of prolonged discharges were associated with reduced processing speed and long‐term memory storage and retrieval.SignificanceCognitive dysfunction is seen in patients with JAE across various cognitive abilities, including those representing more stable processes like general intellect. During 24‐h EEG, prolonged epileptiform discharges are common yet underreported in JAE despite treatment, and they show moderate effects on cognitive abilities. If epileptiform burden is a modifiable predictor of cognitive dysfunction, therapeutic interventions should consider quantitative 24‐h EEG with routine neuropsychological screening. The growing recognition of the spectrum of neuropsychological comorbidities of IGE highlights the value of multidisciplinary approaches to explore the causes and consequences of cognitive deficits in epilepsy.
Chemical vapor deposition derived ultralong SiC nanofibers: structural characterization and growth mechanism
Authors: Liu Debao , Zhang Chao , Xue Yahui 
Published: January 2023

AbstractIn this study, the ultralong SiC nanofibers (SiC NFs) were synthesized through the sol–gel method assisted the chemical vapor deposition technique. The scanning electron microscope, transmission electron microscopy, X‐ray diffraction, Raman, Fourier transform infrared, and X‐ray photoelectron spectroscopy techniques were systematically employed to investigate the microstructure, morphology, and phase composition of the as‐prepared products. The results demonstrated that the as‐obtained products were β‐SiC nanofibers with face‐centered cubic crystal structure. Meanwhile, the ultralong SiC NFs present an average diameter of about 18 nm and a length up to several hundreds of micrometers and grew along the [1 1 1] direction with a planar stacking faults. In addition, we also investigated the formation mechanism and growth process of the ultralong SiC NFs. The successful preparation of such ultralong SiC NFs provides new idea for fabricating of other silicon‐based ultralong nanofibers.
Flexible vehicle scheduling with precedence constraints for tourists
Authors: Liu Zhujun , Moon Ilkyeong , Zhang Ruiyou 
Published: January 2023

AbstractThis research addresses a flexible vehicle scheduling problem considering precedence constraints (FVS‐P problem), which is prevalent in many scenic areas worldwide. Each group of tourists in the FVS‐P problem comprises a set of visit requests that must be served by shuttle vehicles in a predefined order. A three‐indexed integer linear programming model is introduced. Furthermore, an index‐reduction strategy is proposed to strengthen the model. A math‐heuristic route‐segment generation algorithm embedded in a mathematical model is designed to solve the FVS‐P problem, particularly in the case of large‐sized instances. Experiments on different sizes of near‐practical instances validate the mathematical models and the algorithm. The proposed math‐heuristic can provide better solutions for large‐sized instances in a much shorter time than the models. The trade‐off between tourists’ feelings and the cost of the area is investigated to provide further insights for managers.
DNA barcoding of fresh seafood in Australian markets reveals misleading labelling and sale of endangered species
Authors: Khalil Andrew M. , Gainsford Ashton , van Herwerden Lynne 
Published: January 2023

AbstractFlake and shark samples were purchased from outlets in several coastal Australian regions and genetically barcoded using the cytochrome oxidase subunit 1 (CO1) gene to investigate labelling reliability and species‐specific sources of ambiguously labelled fillets. Of the 41 shark fillet samples obtained, 23 yielded high‐quality CO1 sequences, out of which 57% (n = 13) were labelled ambiguously (misleading) and 35% (n = 8) incorrectly. In contrast, barramundi fillets, which are widely available and sought after in Australian markets, were shown to be accurately labelled. Species identified from shark samples, including the shortfin mako (n = 3) and the scalloped hammerhead (n = 1), are assessed by the IUCN as endangered and critically endangered, respectively, with several others classified as vulnerable and near threatened.
Visual–spatial and visuomotor functioning in adults with neurofibromatosis type 1
Authors: Castricum J. , Tulen J. H. M. , Taal W. , Pel J. J. M. , Elgersma Y. 
Published: January 2023

AbstractBackgroundNeurofibromatosis type 1 (NF1) is a neurodevelopmental genetic disorder associated with visual–spatial and visuomotor deficits, which have not been studied well in adults with NF1.MethodsIn 22 adults with NF1 and 31 controls, visuomotor functioning was assessed by measuring eye latency, hand latency and hand accuracy during visuomotor tasks. Visual–spatial functioning was assessed by measuring eye movement responses during the Visual Threshold Task.ResultsThe NF1 group had a significantly shorter eye latency than the control group and was less accurate in their hand movements during specific visuomotor tasks. The groups showed no differences in eye movement responses during the Visual Threshold Task and in hand latency during the visuomotor tasks.ConclusionsIn contrast to studies in children with NF1, we found no alterations in visual–spatial information processing in adults. Impairments in eye latency and hand accuracy during specific visuomotor tasks may indicate deficits in visuomotor functioning in adults with NF1.
Diagnosis and management of hepatic encephalopathy: The French recommendations
Authors: Thabut Dominique , Bouzbib Charlotte , Meunier Lucy , Haas Manon , Weiss Nicolas , Louvet Alexandre , Imbert‐Bismut Francois , Mochel Fanny , Nadjar Yann , Santiago Antoine , Thevenot Thierry , Duhalde Véronique , Oberti Frédéric , Francoz Claire , Coilly Audrey , Hilleret Marie‐Noelle , Lebray Pascal , Liou‐Schischmanoff Amélie , Barbier Louise , Duvoux Christophe , Pageaux Georges‐Philippe , Bismuth Michael , Galanaud Damien , Broucker Thomas De , Cadranel Jean‐François , Leroy Vincent , Di Martino Vincent , Larrey Dominique , Camus Christophe , Scatton Olivier , De Ledinghen Victor , Mallat Ariane , Rudler Marika , Bureau Christophe ,   for the Association Française pour l'Etude du Foie (AFEF) group of experts of HE recommendations
Published: January 2023

AbstractHepatic encephalopathy (HE) is a frequent and severe complication of liver disease with poor patient outcomes. However, it is a poorly understood complication, with no consensus for diagnosis. Therefore, HE is often underdiagnosed. Differential diagnosis may be cumbersome because of non‐specific symptoms, such as confusion, cognitive disorders, the aetiological factors of cirrhosis and comorbidities, which are often observed in cirrhotic patients. Therefore, an overt or covert form of HE should be systematically investigated. Advice is provided to drive patient work‐up. Effective treatments are available to prevent or treat HE bouts, but the issue of single or combination therapy has not been resolved. Transjugular intrahepatic portosystemic shunt (TIPS) placement largely improved the prognosis of cirrhotic patients, but HE occurrence of HE is often a fear, even when post‐TIPS HE can be avoided by a careful selection of patients and preventive treatment. HE is an indication of liver transplantation. However, its reversibility post‐transplantation and the consequences of transplantation in patients with other causes of neurological disorders remain controversial, which supports the performance of an extensive work‐up in expert centres for this subset of patients. The present guidelines assist clinicians in the diagnosis of the overt or covert form of HE to implement curative and preventive treatments and clarify which patients require referral to expert centres for consideration for liver transplantation. These guidelines are very clinically oriented and address different frequent clinical issues to help physicians make bedside decisions.