bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fertility‐sparing approach to malignant ovarian germ cell tumors – Oncologic and obstetric outocome: A retrospective study
Authors: Ayhan Ali , Tunç Mehmet , Akıllı Hüseyin , Haberal Nihan , Haberal Ali 
Published: September 2023

AbstractObjectiveTo evaluate oncologic (such as disease‐free and overall survival) and obstetric outcomes in patients diagnosed with malignant ovarian germ cell tumors (MOGCTs).MethodsPatients diagnosed with MOGCTs between March 2007 and February 2022 were evaluated and patients who underwent fertility sparing surgery were included in this retrospective study. The obstetric and oncologic outcomes were evaluated by collecting data up until the patient's last follow‐up visit from the hospital records and patient files. The study was approved by Başkent University Institutional Review Board (KA23/124).ResultsSeventy FSS patients were included in this study. The median age of the patients was 22.5 years (range: 11–37). The median follow‐up time was 92.0 months (10–189). Immature teratoma was the most common histological subtype (32.9%). Bilateral involvement was detected in only one patient with immature teratoma (1.4%). The 5‐year DFS rates of immature teratoma, dysgerminoma, yolk sac, and mixed germ cell histologic types were 91.1%, 94.1%, 82.4%, and 88.9%, respectively (P: 0.716).The 5‐year OS rates of the same histologic types were 95.7%, 100%, 88.2%, and 88.9%, respectively (P = 0.487). All patients (100%) had a regular menstrual cycle after the completion of adjuvant treatment. The mean time between the last chemotherapy and menstruation was 4.38 months. To date, a total of 34 patients tried to conceive after the completion of disease treatment. A total of 23 (67.6%) patients conceived, resulting in 27 live births in 22 (100%) patients.ConclusionFertility preservation should be the first treatment option in MOGCTs in young patients due to the unilateral involvement of the disease and its chemosensitive nature.
A model program for pharmacist‐managed healthcare delivery: A tixagevimab–cilgavimab (EVUSHELD) clinic at a Veterans Affairs healthcare system
Authors: Buehrle Deanna J. , Shields Jenna , Lopez Marcos , Mascara Gerard P. , Coppler Tami , Mobayed Leeanne , Clancy Cornelius J. 
Published: September 2023

AbstractBackgroundPharmacists are under‐utilized as caregivers who can improve patients' access to medical treatments. In this study, effectiveness of a multidisciplinary pharmacist‐managed clinic in delivering tixagevimab–cilgavimab pre‐exposure coronavirus disease 2019 (Covid‐19) prophylaxis was determined.MethodsAn observational study at the Veterans Affairs (VA) Pittsburgh Healthcare System tixagevimab–cilgavimab clinic from January 1, 2022 to January 1, 2023 was conducted. Pharmacists identified immunocompromised Veterans system‐wide, performed active (telephone) or passive (mail) outreach to those in three highest‐risk categories and a more moderate‐risk category, respectively, and prescribed and dispensed tixagevimab–cilgavimab.ResultsEligible Veterans were stratified into Categories 1 (highest‐risk; 18% [193/1089]), 2 (2% [18/1089]), 3 (17% [188/1089]), or 4 (most moderate‐risk; 63% [690/1089]). Most common underlying conditions were rheumatologic (33%, 356/1089), oncologic (20%, 214/1089), and organ transplantation (18%, 197/1089). Twenty five percent (268/1089) of patients received ≥1 tixagevimab–cilgavimab dose. Acceptance in Categories 1–3 was 63% (121/193), 78% (14/18), and 37% (70/188), respectively (51% overall). Acceptance in Category 4 was 9% (63/690; p < 0.0001 vs. Categories 1–3). To put data into context, <2% of immunosuppressed persons in the United States were reported to receive tixagevimab–cilgavimab. Acceptance was greater among Veterans with rheumatologic or oncologic diseases than those with transplant‐related or neurologic diagnoses (p < 0.0001), and among Covid‐19‐vaccinated versus non‐vaccinated Veterans (27% [261/952] and 5% [7/137], p < 0.0001). Six percent (15/268) and 5% (42/821) of treated and untreated patients, respectively, were subsequently diagnosed in‐system with Covid‐19.ConclusionsA pharmacist‐managed clinic effectively delivered tixagevimab–cilgavimab to immunocompromised Veterans, in particular those at highest Covid‐19 risk. This program is a model for pharmacist‐led clinics for other therapeutics or diseases.
FXII contact activation products have an inhibitory effect on αFXIIa
Authors: Xu Li‐Chong , Siedlecki Christopher A. 
Published: September 2023

AbstractIt is accepted that the contact activation complex of the intrinsic pathway of blood coagulation cascade produces active enzymes that lead to plasma coagulation following biomaterial contact. In this study, FXII was activated through contact with hydrophilic glass beads and hydrophobic octadecyltrichlorosilane‐modified glass beads from neat buffer solutions. These FXII contact activation products generated from material interaction were found to suppress the procoagulant activity of exogenous αFXIIa, and this inhibition was dependent on surface wettability and the concentration of exogenous αFXIIa. Higher relative inhibition rates were generally observed at low concentrations of αFXIIa (1–2 μg/mL) while both hydrophobic and hydrophilic materials showed similar inhibition levels (~39%) at high concentrations of αFXIIa (20 μg/mL). The presence of prekallikrein in the activation system increased the amount of FXIIa produced during FXII contact activation, and also suppressed the apparent levels of inhibitors on hydrophilic surfaces, while having no effect on apparent levels of inhibitors on hydrophobic surface. The combination of FXII contact activation products and activator surfaces was found to dramatically increase inhibition of αFXIIa activity compared to the activation products alone, regardless of activator surface wettability and the presence of prekallikrein. This finding of inhibitors in the suite of proteins generated by contact activation provides additional knowledge into the complex series of interactions that occur when plasma comes into contact with material surfaces.
Internal surface modification of additively manufactured macroporous TiAl6V4 biomimetic implants via a calciothermic reaction‐based process and osteogenic in vivo responses
Authors: Berger Michael B. , Cohen D. Joshua , Deng Jingyao , Srivas Pavan , Boyan Barbara D. , Sandhage Kenneth H. , Schwartz Zvi 
Published: September 2023

AbstractThree‐dimensional macroporous titanium–aluminum–vanadium (TiAl6V4) implants produced by additive manufacturing (AM) can be grit blasted (GB) to yield microtextured exterior surfaces, with additional micro/nano‐scale surface features provided by subsequent acid etching (AE). However, the line‐of‐sight nature of GB causes the topography of exterior GB + AE‐modified surfaces to differ from internal GB‐inaccessible surfaces. Previous in vitro studies using dense TiAl6V4 substrates indicated that a nonline‐of‐sight, calciothermic‐reaction (CaR)‐based process provided homogeneous osteogenic nanotextures on GB + AE surfaces, suggesting it could be used to achieve a homogeneous nanotopography on external and internal surfaces of macroporous AM constructs. Macroporous TiAl6V4 (3D) constructs were produced by direct laser melting and modified by GB + AE, with the CaR process then applied to 50% of constructs (3DCaR). The CaR process yielded nanoporous/nanorough internal surfaces throughout the macroporous constructs. Skeletally mature, male Sprague–Dawley rats were implanted with these constructs using a cranial on‐lay model. Prior to implantation, a Cu++‐free click hydrogel was applied to half of the constructs (3D + H, 3DCaR + H) to act as a challenge to osseointegration. Osseointegration was compared between the four implant groups (3D, 3DCaR, 3D + H, 3DCaR + H) at 4w. 3D + H implants exhibited lower bone volume (BV) and percent bone ingrowth (%BI) than the 3D implants. In contrast, osseointegrated 3DCaR + H implants had similar BV and %BI as the 3DCaR implants. Implant pull‐off forces correlated with these results. In vitro analyses indicated that human bone marrow stromal cells (MSCs) exhibited enhanced production of osteoblast differentiation markers and factors associated with osteogenesis when grown on CaR‐modified 3D substrates relative to control (TCPS) substrates. This work confirms that the CaR process provides osteogenic nanotextures on internal surfaces of macroporous 3D implants, and suggests that CaR‐modified surfaces can promote osseointegration in cases where osteogenesis is impaired.
Toward accurate modeling of structure and energetics of bulk hexagonal boron nitride
Authors: Novotný Michal , Dubecký Matúš , Karlický František 
Published: September 2023

AbstractMaterials that exhibit both strong covalent and weak van der Waals interactions pose a considerable challenge to many computational methods, such as DFT. This makes assessing the accuracy of calculated properties, such as exfoliation energies in layered materials like hexagonal boron nitride (h‐BN) problematic, when experimental data are not available. In this paper, we investigate the accuracy of equilibrium lattice constants and exfoliation energy calculation for various DFT‐based computational approaches in bulk h‐BN. We contrast these results with available experiments and reference fixed‐node diffusion quantum Monte Carlo (QMC) results. From our reference QMC calculation, we obtained an exfoliation energy of 2 meV/atom (‐0.380.02 J/m).
Assessment of monocytic‐myeloid‐derived suppressive cells (M‐MDSC) before and after allogeneic hematopoietic stem cell transplantation in acute leukemia patients
Authors: Peterlin Pierre , Béné Marie C. , Jullien Maxime , Guillaume Thierry , Bourgeois Amandine Le , Garnier Alice , Debord Camille , Eveillard Marion , Chevallier Patrice 
Published: September 2023

AbstractIn this monocentric prospective study, the influence on long‐term outcomes of peripheral blood levels of monocytic‐myeloid‐derived suppressive cells (M‐MDSC) was investigated in 56 patients with acute leukemia (myeloid n = 47; lymphoid n = 9) before and after (Days+60/+90) allogeneic hematopoietic stem cell transplantation (Allo‐HSCT). A risk of relapse was found to be associated with a level of pregraft M‐MDSC above 1.4% by ROC curve analysis. In multivariate analysis, this threshold retained a strong statistical significance (HR: 5.94 [2.09–16.87], p = 0.001). Considering only the group of patients who were in complete remission prior to Allo‐HSCT (n = 44), a significant prediction of relapse was found to be associated, in multivariate analysis, with a level of pregraft M‐MDSC above 1.4% (HR: 55.01 [14.95–202.37], p < 0.001) together with pregraft‐positive measurable ‐residual disease (MRD) (HR: 11.04 [1.89–64.67], p = 0.008). A poorer OS (HR: 6.05 [1.24–29.59], p = 0.026) and disease‐free survival (HR: 6.52 [1.41–30.19], p = 0.016) were also associated with higher levels of pregraft M‐MDSC. Remarkably, no relapse occurred in patients with pregraft‐negative MRD and ≤1.4% of M‐MDSC (vs. a 3‐year relapse rate of 60% for others, p = 0.004). Patients developing grade 3–4 acute graft‐versus‐host‐disease (GVHD, median occurrence: day+30 posttransplant) showed significantly higher levels of M‐MDSC% at days +60 and +90, suggesting a possible amplification of these immunosuppressive cells as a reaction to GVHD. In conclusion, this prospective study demonstrates a negative impact of higher proportions of peripheral M‐MDSC before Allo‐HSCT in leukemic patients. This paves the way to potential therapeutic intervention to decrease M‐MDSC levels before Allo‐HSCT and thus perhaps the incidence of relapse in such patients.
Facile synthesis and anticancer activity of tetrazolyl‐benzothiazole derivatives
Authors: Hsu Yu‐Ju , Shi Wei‐Xin , Tseng Yin‐Chen , Chiu Tzu‐Hao , Cheng Ming‐Hsiang , Chen Kuo‐Ting 
Published: September 2023

AbstractWe herein reported a concise synthesis of a new class of tetrazolyl‐benzothiazoles (TBTs). This synthesis was achieved via a microwave‐assisted ANRORC method followed by an acid‐catalyzed [2 + 3] cycloaddition. The TBT core was elaborated with diverse substituents at the N‐1 or N‐2 position on the tetrazole ring to create a compound library for further bioactivity evaluation. The newly synthesized TBT‐based compounds were assessed for their inhibitory effects against human breast cancer cell lines, MCF‐7 and MDA‐MB‐231. Our results revealed that N‐2 substituted TBTs were generally more active than their N‐1 isomers, and 11g emerged as the most potent inhibitor with IC50 values of 5.3 and 10.4 μg/mL against MCF‐7 and MDA‐MB‐231, respectively. This study provides new insights into the synthesis and anticancer inhibitory activity of TBTs, highlighting their potential for future drug development.
Associations of Alzheimer's Disease Pathology and Small Vessel Disease With Cerebral White Matter Degeneration: A Tract‐Based MR Diffusion Imaging Study
Authors: Li Kaicheng , Wang Shuyue , Luo Xiao , Zeng Qingze , Liu Xiaocao , Hong Luwei , Li Jixuan , Hong Hui , Xu Xiaopei , Zhang Yao , Jiaerken Yeerfan , Zhang Ruiting , Xie Linyun , Xu Shan , Zhang Xinyi , Chen Yanxing , Liu Zhirong , Zhang Minming , Huang Peiyu 
Published: September 2023

BackgroundWhite matter (WM) degeneration is a key feature of Alzheimer's disease (AD). However, the underlying mechanism remains unclear.PurposeTo investigate how amyloid‐β (Aβ), tau, and small vascular disease (SVD) jointly affect WM degeneration in subjects along AD continuum.Study TypeRetrospective.Subjects152 non‐demented participants (age: 55.8–91.6, male/female: 66/86) from the ADNI database were included, classified into three groups using the A (Aβ)/T (tau)/N pathological scheme (Group 1: A−T−; Group 2: A+T−; Group 3: A+T+) based on positron emission tomography data.Field Strength/Sequence3T; T1‐weighted images, T2‐weighted fluid‐attenuated inversion recovery images, T2*‐weighted images, diffusion‐weighted spin‐echo echo‐planar imaging sequence (54 diffusion directions).AssessmentFree‐water diffusion model (generated parameters: free water, FW; tissue fractional anisotropy, FAt; tissue mean diffusivity, MDt); SVD total score; Neuropsychological tests.Statistical TestsLinear regression analysis was performed to investigate the independent contribution of AD (Aβ and tau) and SVD pathologies to diffusion parameters in each fiber tract, first in the entire population and then in each subgroup. We also investigated associations between diffusion parameters and cognitive functions. The level of statistical significance was set at p < 0.05 (false discovery rate corrected).ResultsIn the entire population, we found that: 1) Increased FW was significantly associated with SVD and tau, while FAt and MDt were significantly associated with Aβ and tau; 2) The spatial pattern of fiber tracts related to a certain pathological marker is consistent with the known distribution of that pathology; 3) Subgroup analysis showed that Group 2 and 3 had more alterations of FAt and MDt associated with Aβ and tau; 4) Diffusion imaging indices showed significant associations with cognitive score in all domains except memory.Data ConclusionWM microstructural injury was associated with both AD and SVD pathologies, showing compartment‐specific, tract‐specific, and stage‐specific WM patterns.Evidence Level1Technical EfficacyStage 3
The role of discrete emotions in job satisfaction: A meta‐analysis
Authors: Williams Courtney E. , Thomas Jane Shumski , Bennett Andrew A. , Banks George C. , Toth Allison , Dunn Alexandra M. , McBride Andrew , Gooty Janaki 
Published: September 2023

SummaryThe relationship between emotions and job satisfaction is widely acknowledged via affective events theory (AET). Despite its widespread use, AET was not designed to address why specific emotions might differentially relate to job satisfaction. We utilize appraisal theory of emotion to refine AET and provide this nuanced theorizing. We meta‐analytically test our ideas with 235 samples across 99 883 individuals and 22 600 intra‐individual episodes. We test two approaches—specific emotion experiences (16 discrete emotions) versus general emotion experiences (positive or negative emotions)—and present empirical evidence of their similarities and differences with job satisfaction. Our findings suggest that specific emotions with circumstance‐agency appraisals (e.g., depression and happiness) have the strongest associations with job satisfaction compared to emotions with self‐ and other‐agency appraisals and general emotion experiences. However, more variability is observed for negative emotions and job satisfaction compared to positive emotions. Further, we address and even challenge influential critiques of emotions and job satisfaction via a meta‐analytic test of five moderators—emotion intensity versus frequency, target of emotion, job satisfaction measure, level of analysis, and time referent for emotion and job satisfaction recall. In sum, we advance academic and practitioner understanding of the relationship between emotions and job satisfaction.
When does hindrance appraisal strengthen the effect of challenge appraisal? The role of goal orientation
Authors: Lu Xinxin , Kluemper Donald , Tu Yidong 
Published: September 2023

SummaryChallenge and hindrance appraisals are important to understand the effect of job demands. To date, challenge and hindrance appraisals have been studied in tandem. However, it is unknown whether, how, and when the two appraisals jointly affect employee performance. Integrating effort justification theory and goal orientation theory, the current manuscript seeks to investigate the three‐way interaction effects of challenge appraisal, hindrance appraisal, and both performance‐prove goal orientation and learning goal orientation on task performance via job meaningfulness and activated positive emotions. In a diary study among 96 employees over 10 consecutive workdays (NOccasion = 960, NEmployee = 96), we found that at the daily level, hindrance appraisal strengthens (a) the effects of challenge appraisal of job demands on job meaningfulness and activated positive emotions and (b) the indirect effects of challenge appraisal on task performance via job meaningfulness and activated positive emotions. Furthermore, the strengthening effects of hindrance appraisal are more pronounced as individual trait performance‐prove goal orientation increases, but they do not vary as individual trait learning goal orientation decreases. These research findings shed light on effort justification in explaining the interaction effects of challenge and hindrance appraisals and the role of goal orientation in the process.
Mineral‐solubilizing microbial inoculants facilitate the rejuvenation of soil multifunctionality and plant growth at abandoned mine sites
Authors: Li Chong , Jia Zhaohui , Tang Yingzhou , Zhang Shuifeng , Li Tao , Ma Shilin , Nie Hui , Zhai Lu , Zhang Bo , Liu Xin , Zhang Jinchi , Müller Christoph 
Published: September 2023

AbstractThe mining industry continues to have considerable adverse effects on ecosystems, which necessitates the development of robust and effective strategies for the remediation of abandoned mine sites. One such approach involves the integration of mineral‐solubilizing microorganisms into existing external soil spray seeding technologies. These microorganisms have the capacity to reduce mineral particle sizes, stimulate plant growth, and facilitate the release of essential soil nutrients. Despite the potential benefits of mineral‐solubilizing microbial inoculants, their impacts on overall soil multifunctionality and microbial communities, associations with microbial diversity, soil multifunctionality, and plant growth remain largely unknown. To bridge these knowledge gaps, we conducted a 1‐year greenhouse experiment, which involved a comprehensive assessment of various parameters including soil nutrients, enzyme activities, functional gene copies, and microbial communities. Our findings unveiled that the application of mineral‐solubilizing microbial inoculants led to a significant augmentation of soil multifunctionality. Additionally, the application of microbial inoculants increased the relative abundances of Bacilli (class), Bacillales (order), Bacillaceae (family), and Bacillus (genus). While no significant relationship emerged between microbial alpha diversity and soil multifunctionality, our investigation found positive correlations between the Bacillus groups, keystone ecological cluster, and soil multifunctionality. Furthermore, our results suggested that the indirect impact of microbial inoculants on plant growth was primarily channeled indirectly through their influence on Bacilli, keystone ecological cluster, and soil multifunctionality, as opposed to changes in the overall bacterial or fungal diversity. Overall, our study underscores the significance of mineral‐solubilizing microbial inoculants for the rejuvenation of abandoned mine sites, while providing valuable insights for future research aimed at optimizing the efficacy of external soil spray seeding techniques.
Study of Electrospun PVDF/GO Nanofibers as a Conductive Piezoelectric Heart Patch for Potential Support of Myocardial Regeneration
Authors: Doustvandi Bahareh , Imani Rana , Yousefzadeh Maryam 
Published: September 2023

AbstractHeart patches are currently being utilized to repair damaged myocardium and are a promising way to address the limitations of current therapeutic strategies. Given the electromechanical nature of cardiac tissue, conductive or piezoelectric materials are of interest to researchers. An electrospinning method is used to synthesize and evaluate polyvinylidene fluoride/graphene oxide (PVDF/GO) nanocomposites. Effects of GO concentration (0, 0.1, 0.3, 0.5, 0.7, and 1 wt%) on the main physical‐mechanical characteristics of the patch are studied. Results show nanofibers containing 0.7 wt% GO with a diameter of 857 ± 168 nm, provide excellent tensile strength (0.51 ± 10.34 MPa). Fourier transform infrared and X‐ray diffraction analysis confirm the increase of the β‐polymer phase by adding 1 wt% of GO from 63% to 86%. However, the highest output voltage in the piezoelectric shock test is recorded at 9.44 V for a concentration of 0.5 wt%, which is increased by 8.2 times compared to the neat PVDF. In addition, human umbilical vein endothelial cell culture on the electrospun patches confirmed no toxicity as well as increased cell growth and proliferation (3.4 times) over 7 d. The developed material has the potential to be utilized as a heart patch due to its promising characteristics.
Characterization of fatty acid forms using benchtop NMR in omega‐3 oil supplements
Authors: Remy Carla , Danoun Saïda , Delample Mathieu , Morris Cameron , Gilard Véronique , Balayssac Stéphane 
Published: September 2023

AbstractOmega‐3 fatty acid supplements, such as fish oil and plant‐based oils, have gained popularity because of their potential health benefits. However, the quality and composition of these supplements can vary widely, particularly in terms of the two main forms of omega‐3 fatty acids: triacylglycerols (TAGs) and ethyl esters (EEs). TAGs are the natural form found in fish oil but are prone to oxidation, whereas EEs are more stable but less well absorbed by the body. Differentiating between these forms is crucial for assessing the efficacy and tolerance of omega‐3 supplements. This article describes a novel approach to differentiate between TAG and EE forms of omega‐3 fatty acids in dietary supplements, utilizing a 60‐MHz benchtop nuclear magnetic resonance (NMR) spectrometer. The proposed method using 1H and 1H‐1H COSY NMR provides a quick and accurate approach to screen the forms of omega‐3 fatty acids and evaluate their ratios. The presence of diacylglycerol (DAGs) in some supplements was also highlighted by this method and adds some information about the process used (i.e., esterification/enrichment). The affordability and user‐friendliness of benchtop NMR equipment make this method feasible for food processing companies or quality control laboratories. In this study, 24 oil supplements were analyzed using NMR analysis in order to demonstrate the potential of this method for the differentiation of TAG and EE forms in omega‐3 supplements.