bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Mediterranean Diet and Walking Intervention to Reduce Cognitive Decline and Dementia Risk in Independently Living Older Australians: The MedWalk Randomized Controlled Trial Experimental Protocol, Including COVID-19 Related Modifications and Baseline Characteristics
Authors: Pipingas Andrew , Murphy Karen J. , Davis Courtney R. , Itsiopoulos Catherine , Kingsley Michael , Scholey Andrew , Macpherson Helen , Segal Leonie , Breckon Jeff , Minihane Anne-Marie , Meyer Denny , Ogden Edward , Dyer Kathryn A. , Eversteyn Emily , Hardman Roy J. , Poorun Kaylass , Justice Keri , Hana Maher , Buckley Jonathan D. , White David , Davison Kade , Clark Jessie S. , Bracci Ella L. , Kennedy Greg ,   on behalf of MedWalk collaborative team
Published: September 2023

Background: Several clinical trials have examined diet and physical activity lifestyle changes as mitigation strategies for risk factors linked to cognitive decline and dementias such as Alzheimer’s disease. However, the ability to modify these behaviors longer term, to impact cognitive health has remained elusive. Objective: The MedWalk trial’s primary aim is to investigate whether longer-term adherence to a Mediterranean-style diet and regular walking, delivered through motivational interviewing and cognitive-behavioral therapy (MI-CBT), can reduce age-associated cognitive decline and other dementia risk factors in older, independently living individuals without cognitive impairment. Methods: MedWalk, a one-year cluster-randomized controlled trial across two Australian states, recruited 60–90-year-old people from independent living retirement villages and the wider community. Participants were assigned to either the MedWalk intervention or a control group (maintaining their usual diet and physical activity). The primary outcome is 12-month change in visual memory and learning assessed from errors on the Paired Associates Learning Task of the Cambridge Neuropsychological Test Automated Battery. Secondary outcomes include cognition, mood, cardiovascular function, biomarkers related to nutrient status and cognitive decline, MI-CBT effectiveness, Mediterranean diet adherence, physical activity, quality of life, cost-effectiveness, and health economic evaluation. Progress and Discussion: Although COVID-19 impacts over two years necessitated a reduced timeline and sample size, MedWalk retains sufficient power to address its aims and hypotheses. Baseline testing has been completed with 157 participants, who will be followed over 12 months. If successful, MedWalk will inform interventions that could substantially reduce dementia incidence and ameliorate cognitive decline in the community. Trial registration: Registered on the Australia New Zealand Clinical Trials Registry ANZCTR 12620000978965 ( https://www.anzctr.org.au ).
PROBLEMS OF HUMANIZATION OF THE ENVIRONMENT IN MODERN CONDITIONS
Authors: Kiuntsli Romana , Besaha Iryna , Stepanyuk Andrii 
Published: September 2023

Ukraine has taken significant steps towards integration into the European space during its period of independence. On February 21, 2019, the strategic course of Ukraine towards EU and NATO membership was defined in the Constitution of Ukraine, and as of June 23, 2022, Ukraine is a candidate for membership in the EU. The chosen course of entry into the European space requires changes and improvements in the economic, public, scientific space, and all areas of Ukrainian society. It is important to improve all components of the living environment, namely natural, production, housing, information and media environments, recreation, and daily commuting. At the same time, there is a problem of humanizing the living environment to provide equal conditions and opportunities for full living, work, and leisure for people with disabilities who have long been deprived of this opportunity.
The main tasks of the legal framework in the construction industry are to ensure the reliability and safety of construction objects and to establish requirements that ensure healthy and safe working, living, and domestic conditions for all segments of the population. These tasks have been declared in regulatory documents both during the Soviet period and in the period of Ukraine's independence. However, in practice, not all requirements for architectural and planning solutions for people with disabilities and people with limited mobility were fulfilled. The Ukrainian society's aspiration to integrate into the European space should forever leave behind such phenomena as legal nihilism, especially when it comes to complying with state norms and rules in construction.
A comprehensive approach is needed to create a fully inclusive living environment for all members of society, and simply making changes to building practices is not enough. It is necessary to make radical changes to Ukraine's transportation infrastructure, including retrofitting public transport and improving sanitary transport services to serve people with disabilities and other mobility-impaired groups in society. Creating comfortable conditions for people with disabilities, particularly those with hearing and visual impairments, requires changes in the information and media environment, including the creation of special training programs and visual and media information. It is also necessary to develop a state program for the rehabilitation and employment of war veterans with disabilities.
Examining the Participation of Female Peacekeepers in the United Nations Peacekeeping Operations: The Contributions of Islamic Countries
Authors: Amaliyah Ridha Nahdhiyah Alma , Sallimi Hadidah , Surwandono Surwandono 
Published: September 2023

The world of International Relations will never be separated from its history. Countries in the Middle East, especially Muslim-majority countries, still have a lot of conflicts going on. However, the contribution of Islam to the world of peace never stops. In the contemporary world, for example, this contribution is realized through the participation of Islamic countries in United Nations Peacekeeping Operations (UN PKO). This study aims to analyze the contributions of female peacekeepers of Islamic countries. This research uses the concept of peacekeeping and analyzes secondary data with the quality method and literature review approach as the data collection technique. The result of this research shows that eight of 12 peace missions involved Muslim-majority countries such as Bangladesh, Pakistan, Egypt, and Indonesia, which sent the most female peacekeepers. This study found that the Muslim-majority countries have successfully implemented the UN PKO program, especially for the increasing number of female peacekeepers agenda. It also found that the female peacekeeper has a substantive and public function in the operations, such as their contribution to the operation in logistical, informational branches, and medical aid aspects. However, the UN PKO still emphasizes masculinity. This study shows that domestic issues including inadequate military personnel and social stigmatization of women's peacekeeping engagement greatly reduce women's representation in UN peacekeeping operations. This inherently impacts the Women, Peace, and Security agenda.
SOSIALISASI PEMANFAATAN KOMPUTER DAN INTERNET UNTUK KEGIATAN BELAJAR PADA SISWA SD NEGERI 65 SELUMA SERTA PEMBUATAN WEBSITE DESA KAYU ARANG
Authors: Aprian Endi Taufik , Sari Julia Purnama 
Published: September 2023

Kemajuan ilmu pengetahuan dan teknologi, khususnya teknologi informasi sangat pesat seperti komputer dan internet. Hal itu dikarenakan teknologi informasi menjadi ruang berkembang pesatnya peradaban dunia, begitu pula dengan dunia Pendidikan. Keberadaan teknologi dengan pemanfaatan komputer memiliki dampak yang baik maupun buruk bagi anak-anak. Perlu dilakukan kontrol dan pendampingan yang tepat untuk memastikan bahwa anak-anak menggunakan teknologi ini dengan bijak dan dalam batas yang sehat. Berdasarkan survey, Siswa Sekolah Dasar Negeri 65 Seluma belum memahami pemanfaatan komputer dan internet untuk kegiatan belajar. Oleh karena itu, diperlukan sosialisasi dengan pemberian pemahaman tentang Pemanfaatan Komputer dan Internet untuk kegiatan belajar serta dampak penggunaaannya agar siswa dapat menggunakan komputer dan internet dalam kegiatan belajar dengan benar. Selain itu, pada pengabdian ini juga dilakukan pembuatan website Desa Kayu Arang untuk membantu dalam menyebarkan informasi tentang desa Kayu Arang agar masyarakat desa atau luar dapat mengetahui informasi secara lengkap mengenai desa tersebut.

Kata Kunci: Teknologi, Komputer dan Internet, Sosialisasi, Website, Desa Kayu Arang
Perancangan Komik Historical Fiction Berbasis Cerita Bajak Laut Nusantara
Authors: Lesmana Moh. Eka , Zpalanzani Alvanov , Maslan Riama , Anasthasia D Erline 
Published: September 2023

AbstrakPenggunaan historical fiction pada media populer seperti komik, film, game, dan lain-lain dengan pendekatan hiburan banyak menarik minat masyarakat untuk melihat berbagai fenomena sejarah. Penyampaian dengan pendekatan hiburan ini tentunya menjadi kekuatan dari genre historical fiction untuk dapat digunakan dalam mengangkat berbagai tema-tema sejarah Indonesia. Salah satu fenomena penting dalam sejarah maritim Indonesia yang tidak umum diketahui adalah fenomena ‘bajak laut’. Fenomena bajak laut yang marak di Indonesia pada masa kolonial merupakan bagian dari sejarah Nusantara yang penting karena pada dasarnya fenomena bajak laut di Nusantara tidak sepenuhnya merupakan gejala kriminal, namun juga merupakan bentuk perjuangan masyarakat maritim terhadap para penjajah pada masa lampau. Mengangkat tema ‘bajak laut’ melalui genre historical fiction dapat menjadi upaya untuk menyampaikan peristiwa sejarah maritim melalui pendekatan hiburan dan juga dapat membuka sudut pandang baru bagi masyarakat dalam melihat fenomena ‘bajak laut’ itu sendiri. Komik sebagai media hasil perancangan dipilih dengan melihat potensi media komik dan antusiasme pembaca komik di Indonesia yang sangat tinggi. Perancangan menggunakan metode design thinking and making dari Matt Cooke mulai dari tahap definition, divergent dan transformation menjadi tahapan yang digunakan dalam proses perancangan untuk menghasilkan karya desain yang terstruktur dan bisa menjangkau audiens dengan mudah dan luas. Kata Kunci: bajak laut, historical fiction, komik, Nusantara AbstractThe use of historical fiction in popular media such as comics, films, games, and others with an entertainment approach has attracted a lot of public interest in various historical phenomena. The presentation with entertainment approach is one of the potential of historical fiction genre and can be used in conveying Indonesian history. One of the most important phenomena in Indonesia's maritime history that is not commonly known is the story of 'piracy'. Piracy that flourished in Indonesia during the colonial period was an important part of maritime history because it was not entirely a criminal phenomenon, but was also a form of the battle against the colonialists. Bringing up the theme of 'piracy' through the historical fiction genre can be an effort to convey maritime historical events through an entertainment approach and can also open new perspectives for the public in seeing the phenomenon of 'piracy' itself. Comics were chosen by considering the potential of comics media and the high enthusiasm of comic readers in Indonesia, by using the Matt Cooke’s design thinking and making method from the definition, divergent and transformation it is hoped that the comics can become a medium that can reach an audience easily and widely. Keyword: comics, historical fiction, pirates
Chronic application of alcohol-soluble gluten extract over undamaged skin causes clinical sensitization for life-threatening anaphylaxis via activation of systemic Th2 immune responses in mice
Authors: Jorgensen Rick , Gao Haoran , Chandra Shivam , Sundar Vaisheswini , Loy Jaden , Van Antwerp Chris , Ng Perry K. W. , Gangur Venu 
Published: September 2023

IntroductionGluten allergy is a major public health problem that is growing at an alarming rate. Specific mechanisms underlying sensitization to gluten remain incompletely understood. Currently, it is unclear whether chronic exposure to alcohol-soluble gluten extract via undamaged skin has the capacity to clinically sensitize mice for life-threatening anaphylaxis. Using an adjuvant-free mouse model, here we tested the hypothesis that chronic application of alcohol-soluble durum gluten (ASDG) extract will clinically sensitize mice for life-threatening anaphylaxis.MethodsThis study was conducted in a gluten-free Balb/c mouse colony that was established and maintained on a plant protein-free diet. Groups of adult female mice were exposed dermally to ASDG extract or vehicle once a week for 9-weeks. Specific (s) and total (t) IgE levels were quantified. Mice were challenged systemically with ASDG to measure symptoms of systemic anaphylaxis. Hypothermic shock response (HSR) and mucosal mast cell degranulation response (MMCR) were determined upon challenge. Spleen Th1, Th2, and other immune markers were quantified.ResultsWe found that chronic exposure to ASDG elicited robust elevation of sIgE and tIgE. Systemic challenge with ASDG, but not vehicle, elicited life-threatening anaphylaxis associated with dramatic HSR and MMCR. Correlation analysis demonstrated direct positive inter-relationships among IgE, HSR, and MMCR. Anaphylaxis was associated with significant elevation of prototypic Th2 but not Th1 immune markers in the spleen.Discussion/ConclusionOur study collectively demonstrates that ASDG is intrinsically allergenic; and chronic exposure to ASDG via undamaged skin can clinically sensitize mice for life-threatening anaphylaxis via activating the systemic Th2 immune responses.
Single cell and bulk transcriptome analysis identified oxidative stress response-related features of Hepatocellular Carcinoma
Authors: Zhang Shuqiao , Li Xinyu , Zheng Yilu , Liu Jiahui , Hu Hao , Zhang Shijun , Kuang Weihong 
Published: September 2023

Background: Hepatocellular Carcinoma (HCC) is a common lethal digestive system tumor. The oxidative stress mechanism is crucial in the HCC genesis and progression.Methods: Our study analyzed single-cell and bulk sequencing data to compare the microenvironment of non-tumor liver tissues and HCC tissues. Through these analyses, we aimed to investigate the effect of oxidative stress on cells in the HCC microenvironment and identify critical oxidative stress response-related genes that impact the survival of HCC patients.Results: Our results showed increased oxidative stress in HCC tissue compared to non-tumor tissue. Immune cells in the HCC microenvironment exhibited higher oxidative detoxification capacity, and oxidative stress-induced cell death of dendritic cells was attenuated. HCC cells demonstrated enhanced communication with immune cells through the MIF pathway in a highly oxidative hepatoma microenvironment. Meanwhile, using machine learning and Cox regression screening, we identified PRDX1 as a predictor of early occurrence and prognosis in patients with HCC. The expression level of PRDX1 in HCC was related to dysregulated ribosome biogenesis and positively correlated with the expression of immunological checkpoints (PDCD1LG2, CTLA4, TIGIT, LAIR1). High PRDX1 expression in HCC patients correlated with better sensitivity to immunotherapy agents such as sorafenib, IGF-1R inhibitor, and JAK inhibitor.Conclusion: In conclusion, our study unveiled variations in oxidative stress levels between non-tumor liver and HCC tissues. And we identified oxidative stress gene markers associated with hepatocarcinogenesis development, offering novel insights into the oxidative stress response mechanism in HCC.
A novel [89Zr]-anti-PD-1-PET-CT to assess response to PD-1/PD-L1 blockade in lung cancer
Authors: Puyalto Ander , Rodríguez-Remírez María , López Inés , Iribarren Fabiola , Simón Jon Ander , Ecay Marga , Collantes María , Vilalta-Lacarra Anna , Francisco-Cruz Alejandro , Solórzano Jose Luis , Sandiego Sergio , Peñuelas Iván , Calvo Alfonso , Ajona Daniel , Gil-Bazo Ignacio 
Published: September 2023

BackgroundHarnessing the anti-tumor immune system response by targeting the program cell death protein (PD-1) and program cell death ligand protein (PD-L1) axis has been a major breakthrough in non-small cell lung cancer (NSCLC) therapy. Nonetheless, conventional imaging tools cannot accurately assess response in immunotherapy-treated patients. Using a lung cancer syngeneic mouse model responder to immunotherapy, we aimed to demonstrate that [89Zr]-anti-PD-1 immuno-PET is a safe and feasible imaging modality to assess the response to PD-1/PD-L1 blockade in NSCLC.Materials and methodsA syngeneic mouse model responder to anti-PD-1 therapy was used. Tumor growth and response to PD-1 blockade were monitored by conventional 2-deoxy-2-[18F]fluoro-D-glucose ([18F]-FDG) PET scans. Additionally, tumor lymphocyte infiltration was analyzed by the use of an [89Zr]-labeled anti-PD-1 antibody and measured as 89Zr tumor uptake.ResultsConventional [18F]-FDG-PET scans failed to detect the antitumor activity exerted by anti-PD-1 therapy. However, [89Zr]-anti-PD-1 uptake was substantially higher in mice that responded to PD-1 blockade. The analysis of tumor-infiltrating immune cell populations and interleukins demonstrated an increased anti-tumor effect elicited by activation of effector immune cells in PD-1-responder mice. Interestingly, a positive correlation between [89Zr]-anti-PD-1 uptake and the proportion of tumor-infiltrating lymphocytes (TILs) was found (Cor = 0.8; p = 0.001).ConclusionOur data may support the clinical implementation of immuno-PET as a promising novel imaging tool to predict and assess the response of PD-1/PD-L1 inhibitors in patients with NSCLC.
Evaluation and improvement of workplace vertical violence of nursing interns based on the Importance-Performance Analysis method
Authors: Xu Weifang , Feng Lili , Huang Haohao , Liu Siqi , Ye Mao , Tang Fuqin , Chuang Yen-Ching , Cai Fuman 
Published: September 2023

PurposeTo analyze the key factors related to workplace vertical violence among nursing interns in China and to propose strategies to improve the nursing practice environment.MethodsA cross-sectional study was conducted using the Importance-Performance Analysis (IPA) method to analyze the key factors and significance of workplace vertical violence for nursing interns. The data were obtained by administering a workplace vertical violence survey, designed specifically for this study, to 120 nursing interns at a tertiary general hospital in Zhejiang Province, China.ResultsThe results demonstrated that the variables “I was ordered to do something beyond my ability and lacked guidance (C3),” “Errors in work have been repeatedly emphasized, spread, or exaggerated (C8),” “I was unjustly criticized (C9),” “I was withheld or blocked information purposefully (C1),” and “I was belittled at work (C2)” were the most crucial variables for determining the presence of workplace vertical violence of nursing interns. Moreover, they are priority improvement variables.ConclusionManagers must prioritize the use of relevant resources during internships to minimize false reinforcement and unfair criticism. Efforts should focus on improving information sharing, emphasizing the role of nursing interns in clinical work, providing better guidance when arranging for nursing interns to do work that exceeds their capacity, reducing workplace vertical violence, and improving nursing intern practice environments.
The Human Library and the development of cultural awareness and sensitivity in occupational therapy students: a mixed methods study
Authors: Pope Kirsty , Hewlin-Vita Heather , Chu Eli Mang Yee 
Published: September 2023

IntroductionMonash university in Australia has adopted the Human Library as a teaching activity aimed at enhancing occupational therapy (OT) students’ cultural awareness and sensitivity; however, its effect on cultural competence in healthcare profession students has not been previously investigated.AimTo examine whether participation in a Human Library can facilitate the development of OT students’ cultural awareness and sensitivity and to understand the factors contributing to changes in cultural competence from the students’ perspective.MethodThis is a mixed-method study. Quantitative data was collected by participant characteristic survey and pre/post-Human Library cultural competence assessment (CCA). The quantitative data was used to inform the selection of participants and questions for the second qualitative phase. Quantitative data were analyzed using independent samples and paired t-tests, analysis of variance and Pearson correlation. Qualitative data were analyzed using coding reliability thematic analysis.ResultsStatistically significant increases were noted in CAS, CCB and overall CCA scores from pre- to post-Human Library. Participant characteristics such as gender, work experience in aged care and the health sector had a positive effect on pre-Human Library CCA results. Qualitative data demonstrated that participants perceived they had a level of cultural competence prior to attending the Human Library however, still made gains in cultural awareness and sensitivity and were motivated and inspired to provide culturally congruent healthcare.ConclusionThe Human Library can be considered for inclusion within a suite of learning methods for healthcare professional student curricula as a cost-effective, flexible teaching method for the development of competencies for culturally congruent healthcare.