bluuebunny/crossref_metadata_2025_split huggingface dataset:
EFFECT OF GROWTH REGULATOR ON GROWTH AND YIELD OF BUTTON ROSE
Authors: SELVAVINAYAGAM S. , RAMESHKUMAR S. 
Published: January 2023

A Field study entitled ‘Effect of Growth Regulator on Growth and Yield of Button Rose’ was carried out in a farmer's field near Hosur, Krishnagiri district during 2020-21. The experiment conducted in a randomized block design with three replication. i.e., GA3, NAA, and Tricontanal, along with amino acid and salicylic acid, were also applied with various different combinations, sprayed 30 and 45 days after pruning.The results revealed that Foliar application of (T7) 150 ppm GA3+ salicylic acid consistently registered the highest consistently registered the maximum plant height (110.36), plant spread (43.80 ), number of laterals plant-1 (46.80), number of leaves per plant (181.30), leaf area (42.60) and Chlorophyll (1.65)such as the number of flowers plant-1 day (1.61), days taken for first flowering (45.76) flower diameter (5.83), single flower weight (3.62), flower yield plant-1 day (5.83) was also recorded as the highest in the above treatment. It was followed by (T8), which recorded nest best on-bar values in these parameters. By considering the yield parameters it can be concluded that T7 - GA3 @ 150ppm + Salicylic Acid @ 100ppm was found to have the best effect on growth, flowering and yield parameters of button rose cultivated in open field condition.
MALARIA PARASITE STATUS IN THE STATE OF UTTAR PRADESH BETWEEN 2018 AND 2022
Authors: NATH ARVIND 
Published: January 2023

Background: To the best knowledge of the author, there is no report on the current status of Malaria in the state of Uttar Pradesh, India. This study is an attempt in that direction.
Materials and Methods: The study design included an analysis of the 2017 and 2018 annual reports as well as the website of the of the National Centre for Vector-Borne Diseases Control (NCVBDC).
Results: Bareilly District in Uttar Pradesh had a low Annual Parasite Incidence (API) of Malaria of 0.06 in 2017 which increased to 7.32 in 2018.
Conclusions: If interventions like the treatment of asymptomatic carriers take place, it is expected that the API in this district and the entire state will come down quickly.
ANALISIS SISTEM KENDALI DUA POSISI PADA SOLENOID VALVE UNTUK PRODUK BIOGAS CONTROL AND MONITORING (COMMON-BIGOT) FROM ANIMAL WASTE
Authors: Arifin Imam 
Published: January 2023

Biogas adalah gas yang dihasilkan bakteri apabila bahan organik mengalami proses fermentasi dalam kondisi anaerob, dan akan menghasilkan gas Metana yang disimpan sementara pada sebuah wadah yang disebut Biogas Bag. Pada biogas bag perlu dikontrol untuk memastikan biogas bag tetap aman. Sistem kontrol tersebut berupa kontrol dua posisi karena memiliki keunggulan murah dan sederhana, selain itu solenoid valve sebagai aktuator mempunyai sifat keluaran non-linear. Untuk mendeteksi kapasitas dari biogas bag digunakan sensor jarak HCSR-04 sebagai feedback terhadap nilai set point yang diterakan yaitu 50 cm untuk set point maksimal dan 30 cm untuk set point minimal. Hasil yang didaptakan sensor jarak mampu membaca jarak dengan ketelitian 5.8 % dan kendali On-Off mempunyai respon sebesar 0.25 detik.
Histologic and Immunohistochemical Features of Antemortem Thrombus Compared to Postmortem Clot: Updating the Definition of Lines of Zahn
Authors: Krywanczyk Alison R. , Tan Carmela D. , Rodriguez E. Rene 
Published: January 2023

Context.—
Distinguishing true antemortem thrombus (AMT) from artifactual postmortem clot (PMC) can occasionally be challenging at autopsy. Lines of Zahn are cited as pathognomonic of AMT, but review of literature reveals heterogeneous definitions of the term. Neutrophil karyorrhexis and CD61 immunohistochemistry can also be used to define AMT, but there has been no systematic study determining the specificity of these features.

Objective.—
To identify features that distinguish AMT from PMC, and to clarify the definition of lines of Zahn.

Design.—
PMC from the heart was collected in 50 hospital autopsies. Fifty arterial and 50 venous surgical thrombectomy specimens were reviewed for comparison. The microscopic features with hematoxylin-eosin staining, phosphotungstic acid–hematoxylin (PTAH) staining, and CD61 immunohistochemistry were documented.

Results.—
Thin curvilinear strands of fibrin and clumps of fibrin were frequently observed in both AMT and PMC. Thick bands of nested platelets wrapped in fibrin were nearly exclusive to AMT. Neutrophil karyorrhexis was readily apparent on low power in AMT but was seen in 40 of 50 PMCs (80%) only sparsely on high-power examination. Bone marrow elements were identified in 38 of 50 PMCs (76%). CD61 staining showed a geographic pattern in AMT and a speckled pattern in PMC. PTAH staining confirmed features seen with hematoxylin-eosin.

Conclusions.—
Thin curvilinear strands of fibrin are found in both AMT and PMC and can be misinterpreted as lines of Zahn. We define lines of Zahn as thick bands formed by nested platelets wrapped in fibrin. Diffuse neutrophil karyorrhexis is common in AMT; in contrast, bone marrow elements are often seen in PMC.
Work and illness: a disputed relationship (20th-century Spain)
Authors: Cohen Arón , Fleta Agustín 
Published: January 2023

The concepts of occupational accident, and especially of professional illness, do not express concrete realities that are self-evident by name alone. The recognition of a “link” between work and illnesses has always been a much more gradual, more problematic process than that linking work and accidents in the strict sense of the word.
In this article, we focus on the risks of becoming ill “on the occasion of or as a consequence of work”. In a review of a sample group of around 1,000 court sentences between 1936 and 1983, we analyse the influence of structural inertias, highlighting in particular the signs of change, in line with the evolution of legislation and the way it was interpreted by the courts. The changing social context is also taken into account.
El concepto de accidente de trabajo, y aún más el de enfermedad profesional, no designan realidades que se impongan invariablemente por su sola denominación. El reconocimiento de un "nexo" entre trabajo y enfermedades ha sido en todas partes mucho más tímido y dificultoso que el de los accidentes propiamente dichos.
Con el objetivo puesto en los riesgos de enfermar "con ocasión o por consecuencia del trabajo", una muestra de un millar de sentencias judiciales, repartidas entre 1936 y 1983, comprueba el peso de inercias estructurales y se detiene en los signos de inflexión, en función de la evolución de la legislación de referencia, pero también de sus interpretaciones por los tribunales y de su contexto.
Como expresión normalizada de hechos sociales (los riesgos del trabajo para la salud de quienes lo realizan), el "riesgo profesional" es un objeto en construcción, en un proceso más contradictorio que lineal.
Call for Papers: VI Congreso Internacional SEKLE, Caminos kantianos del pensar.
Authors: Vázquez María Jesús 
Published: January 2023

La Sociedad de Estudios Kantianos en Lengua Española (SEKLE) invita a participar en el Congreso Internacional que tendrá lugar en Santiago de Compostela del 15 al 19 de julio del 2024. El VI Congreso Internacional de la SEKLE celebra no solo el encuentro bienal de esta Sociedad de Estudios Kantianos sino también el tricentenario del nacimiento de Immanuel Kant (1724-1804). El lema Caminos del pensar, evoca metafóricamente tanto el Camino de Santiago y la bella ciudad anfitriona, como los múltiples caminos abiertos por el pensar kantiano a tres siglos de su nacimiento. Consideramos la historia evolutiva de su pensamiento, que, desde nuestro punto de vista, no recorre uno, sino varios caminos, lo que también vale para su historia efectual. Etimológicamente la palabra 'camino' o 'caminos' sugiere el problema del método o de los métodos del pensamiento de Kant y existe en nuestro pensador incluso “un camino que todavía no ha sido nunca hollado” (KrV, A 98), a saber, el de la Deducción trascendental de las categorías. Muchos son los caminos, tanto nacionales como internacionales, que pueden traer a las investigadoras y a los investigadores kantianos a Santiago de Compostela, en ocasión del tricentenario de su nacimiento. Además de los temas mencionados, son bienvenidas las contribuciones sobre cualquier otro aspecto del pensamiento de Kant. Los idiomas del congreso son: español, alemán, portugués, inglés, italiano, francés y gallego.
The Smartness Mandate
Authors: Halpern Orit , Mitchell Robert 
Published: January 2023

Over the last half century, "smartness"—the drive for ubiquitous computing—has become a mandate: a new mode of managing and governing politics, economics, and the environment.
Smart phones. Smart cars. Smart homes. Smart cities. The imperative to make our world ever smarter in the face of increasingly complex challenges raises several questions: What is this "smartness mandate"? How has it emerged, and what does it say about our evolving way of understanding—and managing—reality? How have we come to see the planet and its denizens first and foremost as data-collecting instruments?
In The Smartness Mandate, Orit Halpern and Robert Mitchell radically suggest that "smartness" is not primarily a technology, but rather an epistemology. Through this lens, they offer a critical exploration of the practices, technologies, and subjects that such an understanding relies upon—above all, artificial intelligence and machine learning. The authors approach these not simply as techniques for solving problems of calculations, but rather as modes of managing life (human and other) in terms of neo-Darwinian evolution, distributed intelligences, and "resilience," all of which have serious implications for society, politics, and the environment.
The smartness mandate constitutes a new form of planetary governance, and Halpern and Mitchell aim to map the logic of this seemingly inexorable and now naturalized demand to compute, illuminate the genealogy of how we arrived here, and point to alternative imaginaries of the possibilities and potentials of smart technologies and infrastructures.
PLP1 gene mutations cause spastic paraplegia type 2 in three families
Authors: Yao Li , Zhu Zeyu , Zhang Chao , Tian Wotu , Cao Li 
Published: January 2023

AbstractObjectiveSpastic paraplegia type 2 (SPG2) is an X‐linked recessive (XLR) form of hereditary spastic paraplegia (HSP) caused by mutations in proteolipid protein 1 (PLP1) gene. We described the clinical and genetic features of three unrelated families with PLP1 mutations and reviewed PLP1‐related cases worldwide to summarize the genotype–phenotype correlations.MethodsThe three probands were 23, 26, and 27 years old, respectively, with progressively aggravated walking difficulty as well as lower limb spasticity. Detailed physical examination showed elevated muscle tone, hyperreflexia, and Babinski signs in lower limbs. Brain MRI examinations were investigated for all cases. PLP1 mutations were identified by whole exome sequencing, followed by Sanger sequencing, family co‐segregation, and phenotypic reevaluation.ResultsA total of eight patients with SPG2 were identified in these three families. The probands additionally had cognitive impairment, urinary or fecal incontinence, ataxia, and white matter lesions (WML) in periventricular regions, with or without kinetic tremor. Three hemizygous mutations in PLP1 were identified, including c.453+159G>A, c.834A>T (p.*278C), and c.434G>A (p.W145*), of which c.834A>T was first associated with HSP.InterpretationWe identified three families with complicated SPG2 due to three PLP1 mutations. Our study supports the clinically inter‐and intra‐family heterogeneity of SPG2. The periventricular region WML and cognitive impairment are the most common characteristics. The kinetic tremor in upper limbs was observed in 2/3 families, suggesting the spectrum of PLP1‐related disorders is still expanding.
Mobile digital gait analysis objectively measures progression in hereditary spastic paraplegia
Authors: Loris Evelyn , Ollenschläger Malte , Greinwalder Teresa , Eskofier Björn , Winkler Jürgen , Gaßner Heiko , Regensburger Martin 
Published: January 2023

AbstractProgressive spasticity and gait impairment is the functional hallmark of hereditary spastic paraplegia (HSP), but due to inter‐individual variability, longitudinal studies on its progression are scarce. We investigated the progression of gait deficits via mobile digital measurements in conjunction with clinical and patient‐reported outcome parameters. Our cohort included adult HSP patients (n = 55) with up to 77 months of follow‐up. Gait speed showed a significant association with SPRS progression. Changes in stride time and gait variability correlated to fear of falling and quality of life, providing evidence that gait parameters are meaningful measures of HSP progression.
Engineered Platelet‐Derived Growth Factor‐Releasing Hydrogels Promote Fetal Membrane Healing In Vivo
Authors: Avilla‐Royo Eva , Vonzun Ladina , Seehusen Frauke , Vallmajo‐Martin Queralt , Famos Flurina , Moser Lukas , Gegenschatz‐Schmid Katharina , Krattiger Lisa Amanda , Strübing Nele , Weisskopf Miriam , Moehrlen Ueli , Ochsenbein‐Kölble Nicole , Ehrbar Martin 
Published: January 2023

AbstractFetoscopic interventions to treat fetal anomalies are currently performed for a variety of conditions. Depending on the procedure, preterm rupture of the fetal membranes (FMs) happens in around 30% of the cases, potentially leading to preterm birth and fetal morbidity and mortality. Here, the capacity of modular transglutaminase crosslinked poly(ethylene glycol) (TG‐PEG) hydrogels that release platelet‐derived growth factor (PDGF)‐BB to promote FM healing is described. In vitro, such growth factor‐loaded hydrogels are able to stimulate amniotic cell migration and proliferation. When applied in vivo, these TG‐PEG hydrogels tightly seal the FM and uterus defects created by a fetoscope and remain stable for 10 days. The migration of healing‐related cells into such hydrogels in the myometrium, endometrium, and FM areas is only possible in soft TG‐PEG hydrogels. Importantly, bioengineered hydrogels releasing PDGF‐BB promote recruitment of host cells from the myometrium and the endometrium, and to a lesser extent from FM areas. In such hydrogels, the potent proliferation and matrix production of the recruited cells at the site of treatment into the biomaterial initiates a robust early healing response. PDGF‐BB‐loaded TG‐PEG hydrogels hold great promise for the treatment of fetoscopy‐induced FM defects and for the prevention of preterm birth.
Immuno‐Desorption Electrospray Ionization Mass Spectrometry Imaging Identifies Functional Macromolecules by Using Microdroplet‐Cleavable Mass Tags
Authors: Song Xiaowei , Zang Qingce , Li Chao , Zhou Tianhao , Zare Richard N. 
Published: January 2023

AbstractWe present immunoassay‐based desorption electrospray ionization mass spectrometry imaging (immuno‐DESI‐MSI) to visualize functional macromolecules such as drug targets and cascade signaling factors. A set of boronic acid mass tags (BMTs) were synthesized to label antibodies as MSI probes. The boronic ester bond is employed to cross‐link the BMT with the galactosamine‐modified antibody. The BMT can be released from its tethered antibody by ultrafast cleavage of the boronic ester bond caused by the acidic condition of sprayed DESI microdroplets containing water. The fluorescent moiety enables the BMT to work in both optical and MS imaging modes. The positively charged quaternary ammonium group enhances the ionization efficiency. The introduction of the boron element also makes mass tags readily identified because of its unique isotope pattern. Immuno‐DESI‐MSI provides an appealing strategy to spatially map macromolecules beyond what can be observed by conventional DESI‐MSI, provided antibodies are available to the targeted molecules of interest.
Designing High‐Donicity Anions for Rechargeable Potassium Superoxide/Peroxide Batteries
Authors: Qin Lei , Schkeryantz Luke , Wu Yiying 
Published: January 2023

AbstractA battery cathode based on the superoxide/peroxide redox not only inherits the advantage of oxygen (O2) batteries in high capacities and low costs but also overcomes the disadvantages in O2storage, electrolyte evaporation, and anode deactivation due to O2crossover. Herein, we report an enhanced potassium superoxide (KO2)/peroxide (K2O2) conversion by adopting a high‐donicity anion additive in the ether‐based electrolyte. Such an anion was synthesized via a “Solvent‐in‐Anion” strategy and validated to enhance the electron donicity of the electrolyte. The use of high‐donicity anion could lead to enhanced KO2utilization (≈90.2 %) by retarding electrode passivation and allow the full charging back of K2O2through the solution‐mediated pathway without electrocatalysts. No apparent cell degradation is observed during the first 120 cycles by controlling the reversible depth‐of‐discharge capacity at 292 mAh g−1within an O2‐free region. The K−KO2cell delivers a high energy efficiency (>84.4 %) and a lifespan of over 1440 hours.
Structure–activity relationship study to improve cytotoxicity and selectivity of lonafarnib against breast cancer cells
Authors: Hongnak Siriwat , Gust Ronald 
Published: January 2023

AbstractLonafarnib is designed as a farnesyltransferase (FTase) inhibitor and displays inhibitory activities against a wide range of tumor cells. However, a major disadvantage is its unselective activity and high cytotoxicity against nonmalignant cells. Therefore, we structurally modified the terminal 4‐methylpiperidine‐1‐carboxamide residue of lonafarnib and evaluated the antiproliferative effects of the resulting derivatives in Michigan Cancer Foundation ‐ 7 (MCF‐7) breast cancer cells as well as simian virus 80 (SV‐80) fibroblasts. The highest cytotoxicity against both cell lines (IC50 about 2 µM) was shown by the piperidin‐4‐yl carbamate 15i and the S‐(piperidin‐4‐yl) carbamothioate 15j. Selectivity for tumor cells was realized in the case of the 1‐cyclohexyl‐1‐methylurea derivative 15b. It reduced the growth of MCF‐7 cells with an IC50 of 11.4 µM (lonafarnib: IC50 = 10.8 µM) without influence on the growth of SV‐80 cells (IC50 > 50 µM; lonafarnib: IC50 = 14.0 µM). Molecular modeling studies were performed to correlate the cytotoxicity with possible FTase interactions. The theoretical investigations, however, documented a comparable attachment of active, less active, and inactive compounds and did not allow an interpretation of the biological results based on these theoretical considerations.
Payment with knowledge: A method for a training of anatomy near‐peer teachers and formation of future anatomists
Authors: Guerrero‐Mendivil Francisco Daniel , Elizondo‐Omaña Rodrigo Enrique , Jacobo‐Baca Guillermo , Quiroz‐Perales Xavier Gerardo , Salinas‐Alvarez Yolanda , Martinez‐Garza Javier Humberto , de la Fuente‐Villarreal David , Quiroga‐Garza Alejandro , Guzman‐Lopez Santos 
Published: January 2023

AbstractNear‐peer teaching has been widely implemented in medical schools and the benefits for the near‐peer teachers (NPTs), the students, and the institution have been well documented. However, NPT training methods and perceptions of such have been limited. A four‐year clinical anatomy and surgical training program was established (est. 2019) as part of the continuous training timeline for NPTs (n > 60 total) formation at the Universidad Autónoma de Nuevo León, in Mexico. The program provides various training courses for the NPTs according to their hierarchy, including teaching skills, professional development, psychosocial aspects, and career objectives. A “Clinical Anatomy and Surgical Training Diploma” was planned with 12 modules to aid in developing these abilities, along with a higher understanding of clinical anatomy shared by expert clinical specialists, and diverse clinical and surgical skills such as suturing, catheterization, and basic surgical procedures. The program has a completion rate of approximately 15 NPTs/year. All, while creating an environment with a sense of belonging, and facilitating mentorship between fellow NPTs and educators. Near‐peer teachers develop leadership, communication, and teaching skills. The program has provided a constant source of anatomy educators, avoiding any shortage.
Further results for synchronization of two coupled Boolean networks
Authors: Xu Die , Pan Qinyao , Zhong Jie , Li Bowen 
Published: January 2023

AbstractThis paper investigates the complete synchronization of drive‐response Boolean networks (BNs) using the semi‐tensor product of matrices. First, a necessary and sufficient condition for complete synchronization is obtained. Next, a pinning control method for achieving complete synchronization of drive‐response BNs is proposed, based on certain transformations of the state transition matrix of drive BN. Then, an algorithm is proposed to obtain the minimum number of pinning nodes, based on the perturbation method. Finally, two numerical examples are given to verify the validity of the study results.
Mechanical dissection and culture of mouse cranial neural crest cells
Authors: Tian Yu , Lin Junyan , Li Xiaofeng , Zhu Guirong , Fan Liwen , Lou Shu , Li Dandan , Pan Yongchu 
Published: January 2023

AbstractOwing to the contribution of cranial neural crest cells (CNCCs) to the majority of craniofacial structures, they have been studied extensively for the pathogenesis of craniofacial diseases. To investigate and summarize how to isolate and culture the CNCCs from wild‐type mice, a literature search was performed in online databases (PubMed and Web of Science) using optimized keywords “mouse,” “cranial neural crest cell” and “culture.” The literature was checked by two investigators according to the screening and exclusion criteria. Initially, 197 studies were retrieved from PubMed and 169 from Web of Science, and after excluding replicate studies, 293 articles were considered. Finally, 17 studies met all the criteria and were included in this review. The results showed that obtaining purified stem cells and balancing the need to promote cell growth and prevent unwanted early cell differentiation were the two key points in the isolation and culture of CNCCs. However, no standard criteria are available for answering these questions. Thus, it is important to emphasize the necessity for standardization of CNCC isolation, culture, and identification in research on craniofacial diseases.