bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neuropsychiatric comorbidities and cognition in epilepsy with eyelid myoclonia: A retrospective pediatric case series
Authors: Ballarà Petitbò Maria , González Alguacil Elena , Gutiérrez Delicado Eva , Ortiz Cabrera Nelmar Valentina , Duat Rodríguez Anna , García Peñas Juan José , Soto Insuga Victor 
Published: August 2023

AbstractObjectiveEpilepsy with eyelid myoclonia (EEM) is a rare epileptic syndrome classified within the Genetic Generalized Epilepsies of childhood. It is characterized by a high drug resistance, and little is known about prognostic factors and neurodevelopmental comorbidities. The aim of this study was to describe the clinical features, cognitive profile, and prognostic factors in a series of children with EEM.MethodsThis is a retrospective observational study of patients diagnosed with EEM from 2012 to 2022 in a tertiary pediatric hospital.ResultsSeventeen patients were analyzed (mean age at symptom onset 5.8 years). Neuropsychiatric comorbidities were present in 76.4% (attention deficit hyperactivity disorder 58.8%, behavioral disorder 11.8%, autism spectrum disorder 11.8%, and psychotic outbreaks 11.8%). Neurocognitive assessment was performed in 75%, revealing cognitive impairment in 66.6% (62.5% with borderline intellectual function and 37.5% with ‐IQ <70‐), with predominant difficulties in executive functions, comprehensive language, and motor skills. Cognitive deterioration was observed in one patient in parallel onset with psychotic symptoms. High refractoriness to antiseizure medication (ASM) was observed, with only 23.5% of the patients being seizure‐free after a mean follow‐up of 7 years. The most effective ASM was valproic acid, and two of them received ketogenic diet with good response. Regarding prognostic factors, psychotic symptoms were associated with a greater number of antiseizure medication (p < .05) implying a more drug‐resistant epilepsy.SignificanceIn our study, we found a high rate of cognitive and psychiatric comorbidities and high refractoriness. These data support the concept of EEM as an intermediate entity between idiopathic generalized epilepsy and epileptic and/or neurodevelopmental encephalopathy. Making a proper diagnosis and management of these comorbidities is necessary to improve prognosis and quality of life in EEM.
FTO‐mediated epigenetic upregulation of LINC01559 confers cell resistance to docetaxel in breast carcinoma by suppressing miR‐1343‐3p
Authors: Lin Wei , Mo Cai‐Qin , Kong Ling‐Jun , Chen Ling , Wu Kun‐Lin , Wu Xian 
Published: August 2023

AbstractThis study was to explore the regulatory effect of long non‐coding RNA LINC01559 on Docetaxel resistance in breast carcinoma (BCa) and its underlying mechanism. In the present study, we found that LINC01559 expression was elevated and LINC01559 overexpression facilitated docetaxel resistance in BCa cells. Moreover, it was revealed that the upregulation of LINC01559 in BCa cells was induced by FTO‐mediated demethylation in an m6A‐YTHDF2‐dependent manner. Additionally, Dual‐luciferase reporter assay confirmed the binding ability between LINC01559 and miR‐1343‐3p, and Pearson correlation analysis showed a negative correlation between them. Particularly, miR‐1343‐3p inhibition partly abolished the suppression on docetaxel resistance in BCa cells caused by LINC01559 knockdown. To sum up, FTO‐mediated epigenetic upregulation of LINC01559 promoted cell resistance to Docetaxel in BCa by negatively regulating miR‐1343‐3p.
Erratic birational behavior of mappings in positive characteristic
Authors: Cutkosky Steven Dale 
Published: August 2023

AbstractBirational properties of generically finite morphisms of algebraic varieties can be understood locally by a valuation of the function field of X. In finite extensions of algebraic local rings in characteristic zero algebraic function fields which are dominated by a valuation, there are nice monomial forms of the mapping after blowing up enough, which reflect classical invariants of the valuation. Further, these forms are stable upon suitable further blowing up. In positive characteristic algebraic function fields, it is not always possible to find a monomial form after blowing up along a valuation, even in dimension two. In dimension two and positive characteristic, after enough blowing up, there are stable forms of the mapping which hold upon suitable sequences of blowing up. We give examples showing that even within these stable forms, the forms can vary dramatically (erratically) upon further blowing up. We construct these examples in defect Artin–Schreier extensions which can have any prescribed distance.
Visualizing Penetration of Fluorescent Dye through Polymer Coatings
Authors: Chaudhuri Krishnaroop , Medhi Riddhiman , Zhang Zhenglin , Cai Zhuoyun , Ober Christopher K. , Pham Jonathan T. 
Published: August 2023

AbstractUnderstanding how small molecules penetrate and contaminate polymer films is of vital importance for developing protective coatings for a wide range of applications. To this end, rhodamine B fluorescent dye is visualized diffusing through polystyrene‐polydimethylsiloxane block copolymer (BCP) coatings using confocal microscopy. The intensity of dye inside the coatings grows and decays non‐monotonically, which is likely due to a combination of dye molecule transport occurring concurrently in different directions. An empirical fitting equation allows for comparing the contamination rates between copolymers, demonstrating that dye penetration is related to the chemical makeup and configuration of the BCPs. This work shows that confocal microscopy can be a useful tool to visualize the transport of a fluorophore in space and time through a coating.
Use of carbon‐13 NMR to identify known natural products by querying a nuclear magnetic resonance database—An assessment
Authors: Nuzillard Jean‐Marc 
Published: August 2023

AbstractThe quick identification of known organic low molecular weight compounds, also known as structural dereplication, is a highly important task in the chemical profiling of natural resource extracts. To that end, a method that relies on carbon‐13 nuclear magnetic resonance (NMR) spectroscopy, elaborated in earlier works of the author's research group, requires the availability of a dedicated database that establishes relationships between chemical structures, biological and chemical taxonomy, and spectroscopy. The construction of such a database, called acd_lotus, was reported earlier, and its usefulness was illustrated by only three examples. This article presents the results of structure searches carried out starting from 58 carbon‐13 NMR data sets recorded on compounds selected in the metabolomics section of the biological magnetic resonance bank (BMRB). Two compound retrieval methods were employed. The first one involves searching in the acd_lotus database using commercial software. The second one operates through the freely accessible web interface of the nmrshiftdb2 database, which includes the compounds present in acd_lotus and many others. The two structural dereplication methods have proved to be efficient and can be used together in a complementary way.
Pulmonary tumor thrombotic microangiopathy: Exploration into current diagnostic aids and therapeutics
Authors: Ramakrishnan Pavithra , Dahiya Garima , Lindstrom Meghan , Thenappan Thenappan 
Published: August 2023

AbstractPulmonary tumor thrombotic microangiopathy (PTTM) is an under‐recognized cause of pulmonary hypertension and fulminant right ventricle failure. It is associated with a high mortality due to delay in diagnosis. We present two cases of PTTM, both diagnosed postmortem, highlighting the importance of timely identification and initiation of treatment for this near‐fatal condition.
On‐line instrumental variable‐based feedforward tuning for non‐resetting motion tasks
Authors: Mooren Noud , Witvoet Gert , Oomen Tom 
Published: August 2023

SummaryData‐driven feedforward control for tracking of varying and non‐resetting point‐to‐point references requires continuous updating of feedforward parameters instead of task‐by‐task updating. The aim of this paper is to develop an adaptive feedforward controller for non‐resetting point‐to‐point motion tasks by a data‐driven feedforward controller. An approximate optimal instrumental variable (IV) estimator with real‐time bootstrapping is employed in a closed‐loop setting to update the feedforward parameters. A case study on a wafer‐stage and experimental validation on a benchmark motion system show the performance benefit.
Glutathione‐Titanate Nanosheets for the Adsorption of Lysozyme from Aqueous Solution: Kinetic, Isotherms, and Thermodynamic Studies
Authors: Pan Junli , Sun Wenjie , Kang Didi , Xia Heying , Liu Dan 
Published: August 2023

AbstractIn this study, GSH‐γ‐MAPS‐TiNS nanosheets were prepared and characterized using scanning electron microscopy (SEM), Fourier‐transform infrared spectroscopy (FT‐IR), X‐ray diffraction (XRD), X‐ray photoelectron spectrometric (XPS), contact angle, and specific surface area (BET). The characterization results confirmed GSH‐γ‐MAPS‐TiNS have been successfully synthesized, and the nanosheets structure and satisfactory hydrophilicity have been obtained. The synthesized composites were applied for the adsorption of lysozyme from aqueous solution, and the effects of operation parameters on adsorption efficiency were optimized. The results of adsorption kinetics demonstrated that the process followed pseudo‐second‐order kinetic model. Moreover, the adsorption isotherm was well described by Freundlich model, which implied that multilayer adsorption occurred on prepared nanosheets for lysozyme adsorption. The negative values of Gibbs free energy change (ΔG°<0) demonstrated that lysozyme adsorption was a spontaneous process. The positive values of entropy change (ΔS°>0) implied that lysozyme adsorption was an increasing random process. Enthalpy change values were positive (ΔH°>0), indicated that lysozyme adsorption was endothermic. Furthermore, GSH‐γ‐MAPS‐TiNS was treated sequentially with MeOH for regeneration, achieving a high desorption percentage of 91.76 %. The intra‐batch and inter‐batch RSD values were determined to be 2.2 and 8.2 %, respectively. These results indicated that GSH‐γ‐MAPS‐TiNS have the potential ability for the adsorption of lysozyme from aqueous solution.
An empirical study to compare three web test automation approaches: NLP‐based, programmable, and capture&replay
Authors: Leotta Maurizio , Ricca Filippo , Marchetto Alessandro , Olianas Dario 
Published: August 2023

AbstractA new advancement in test automation is the use of natural language processing (NLP) to generate test cases (or test scripts) from natural language text. NLP is innovative in this context and promises of reducing test cases creation time and simplifying understanding for “non‐developer” software testers as well. Recently, many vendors have launched on the market many proposals of NLP‐based tools and testing frameworks but their superiority has never been empirically validated. This paper investigates the adoption of NLP‐based test automation in the web context with a series of case studies conducted to compare the costs of the NLP testing approach—measured in terms of test cases development and test cases evolution—with respect to more consolidated approaches, that is, programmable (or script‐based) testing and capture&replay testing. The results of our study show that NLP‐based test automation appears to be competitive for small‐ to medium‐sized test suites such as those considered in our empirical study. It minimizes the total cumulative cost (development and evolution) and does not require software testers with programming skills.
The Gender–energy–poverty Nexus Under Review: A Longitudinal Study for Spain
Authors: Toro Francisca , Fernández-Vázquez Esteban , Serrano Mònica 
Published: August 2023

AbstractLinks between gender, poverty, and energy have been hinted at in many studies mainly focused on livelihood strategy and economic development of low income, showing that the consequences of energy poverty may vary between women and men mainly because women are more exposed to deal with energy-related activities. At the European Union, where more than 50 million people are unable to afford proper indoor thermal comfort, the main research constraint is the lack of publicly access to gender-disaggregated data on energy poverty. This chapter contributes to literature on the gender–energy–poverty nexus, providing a quantitative analysis of the gender differences in energy consumption from a longitudinal perspective to empirically support previous studies on the topic. We focus on Spain as a case study, by using longitudinal data from Spanish Household Budget Survey from 1998 to 2018. To better analyze the gender effects, we study the energy consumption patterns of female and male breadwinner households as well as female and male one-person households. We also apply an Ordinary Least Square regression model to analyze the significance of gender and expenditure level considering the expenditure on residential energy and transport fuels and controlling for other household characteristics.
Effects of Carbon Tax Redistribution Schemes on Energy Welfare of Households in Germany
Authors: Dobbins Audrey , Fahl Ulrich 
Published: August 2023

AbstractIncreasing carbon taxes have the potential to disproportionately affect lower income households, who lack the financial and decision-making capacity to undertake investments to shift the underlying energy system. Carbon tax redistribution schemes aim to equalise the negative impacts experienced especially in lower income households and tenants. Through the development of a dedicated energy system optimisation model, our assessment evaluated the distributional impacts of carbon tax redistribution schemes on the evolution of energy use, emissions and energy welfare in different household types in Germany.
Households’ Energy Demand and Carbon Taxation in Italy
Authors: Faiella Ivan , Lavecchia Luciano 
Published: August 2023

AbstractSince the second half of 2021, Italian households have experienced a significant increase in energy prices. Nonetheless the relevance of this issue, information on energy use and how quantity reacts to price increases is still scant and with a very limited level of disaggregation. We propose a novel methodology to estimate the demand and elasticity of electricity, heating and private transport fuels by aligning the microdata of the Italian Household Budget Survey with several external sources. These estimates can be used to assess how energy expenditure weighs on vulnerable households and the effects of a carbon tax. A carbon tax would—as expected—raise significant revenues and curb CO2 emissions but it could also have sizable regressive effects. In order to limit these undesired effects and to increase social consensus, policymakers should devise a set of suitable revenue recycling strategies.
AMBRA1 phosphorylation by CDK1 and PLK1 regulates mitotic spindle orientation
Authors: Faienza Fiorella , Polverino Federica , Rajendraprasad Girish , Milletti Giacomo , Hu Zehan , Colella Barbara , Gargano Deborah , Strappazzon Flavie , Rizza Salvatore , Vistesen Mette Vixø , Luo Yonglun , Antonioli Manuela , Cianfanelli Valentina , Ferraina Caterina , Fimia Gian Maria , Filomeni Giuseppe , De Zio Daniela , Dengjel Joern , Barisic Marin , Guarguaglini Giulia , Di Bartolomeo Sabrina , Cecconi Francesco 
Published: August 2023

AbstractAMBRA1 is a crucial factor for nervous system development, and its function has been mainly associated with autophagy. It has been also linked to cell proliferation control, through its ability to regulate c-Myc and D-type cyclins protein levels, thus regulating G1-S transition. However, it remains still unknown whether AMBRA1 is differentially regulated during the cell cycle, and if this pro-autophagy protein exerts a direct role in controlling mitosis too. Here we show that AMBRA1 is phosphorylated during mitosis on multiple sites by CDK1 and PLK1, two mitotic kinases. Moreover, we demonstrate that AMBRA1 phosphorylation at mitosis is required for a proper spindle function and orientation, driven by NUMA1 protein. Indeed, we show that the localization and/or dynamics of NUMA1 are strictly dependent on AMBRA1 presence, phosphorylation and binding ability. Since spindle orientation is critical for tissue morphogenesis and differentiation, our findings could account for an additional role of AMBRA1 in development and cancer ontogenesis.
Integrability in the Chiral Model of Magic Angles
Authors: Becker Simon , Humbert Tristan , Zworski Maciej 
Published: August 2023

AbstractMagic angles in the chiral model of twisted bilayer graphene are parameters for which the chiral version of the Bistritzer–MacDonald Hamiltonian exhibits a flat band at energy zero. We compute the sums over powers of (complex) magic angles and use that to show that the set of magic angles is infinite. We also provide a new proof of the existence of the first real magic angle, showing also that the corresponding flat band has minimal multiplicity for the simplest possible choice of potentials satisfying all symmetries. These results indicate (though do not prove) a hidden integrability of the chiral model.
Rigorous Derivation of the Oberbeck–Boussinesq Approximation Revealing Unexpected Term
Authors: Bella Peter , Feireisl Eduard , Oschmann Florian 
Published: August 2023

AbstractWe consider a general compressible viscous and heat conducting fluid confined between two parallel plates and heated from the bottom. The time evolution of the fluid is described by the Navier–Stokes–Fourier system considered in the regime of low Mach and Froude numbers suitably interrelated. Surprisingly and differently to the case of Neumann boundary conditions for the temperature, the asymptotic limit is identified as the Oberbeck–Boussinesq system supplemented with non-local boundary conditions for the temperature deviation.
Leukocyte esterase and alpha-defensin in periprosthetic joint infection: predictive quality and correlation in a prospective study
Authors: Grünwald Leonard , Schmidutz Florian , Döttger Philipp , Erne Felix , Schreiner Anna Janine , Hemmann Philipp 
Published: August 2023

Abstract
Purpose
Periprosthetic joint infection (PJI) is a rare but serious complication of total joint arthroplasty (TJA). An accurate diagnosis of PJI preoperatively does not exist. Alpha-defensin (AD) is a proven and common indicator. The diagnostic marker of leukocyte esterase (LE) promises some advantages: feasibility, availability, and fast result reporting. The aim of this study was the evaluation of the predictive quality and correlation between both diagnostic tools in the diagnosis of PJI.

Methods
A prospective study was conducted between April 2018 and August 2022. All patients with suspicion of PJI on hip and knee joint were included and underwent a routine and standardized joint punction. For laboratory diagnostics of AD, the synovial liquid was analyzed by ELISA. The sample was additionally applied to a LE test strip (Combur 10 Test, Roche Diagnostics, Mannheim, Germany).

Results
A total of 249 patients were examined (mean age 67.12 ± 11.89; gender distribution man/woman 139 (55.8%)/110(44.2%), hip/knee 71(28.5%)/178 (71.5%). According to EBJIS criteria, PJI was diagnosed in 54 (21.7%) patients. AD showed excellent results with an AUC of 0.930 (sensitivity/specificity 0.870/0.990). LE yielded very good results with an AUC of 0.820 (sensitivity/specificity 0.722/0.918). Both parameters showed a strong positive correlation.

Conclusion
LE is a rapidly available alternative in PJI diagnostics. The simultaneous determination of both markers may enhance diagnostic reliability. A routine usage may shorten the time from diagnosis to treatment of PJI.
Long-term home ranging in the large sea cucumber, Holothuria fuscopunctata
Authors: Purcell Steven W. , Rallings Sophie L. , Hammond Alison R. 
Published: August 2023

AbstractLong-term movements of adult marine animals predicate spatial management measures. Sea cucumbers are intensely exploited worldwide, yet few studies have assessed their long-term movement potential. Elephant trunkfish, Holothuria (Microthele) fuscopunctata, is a large coral reef holothuroid. At four sites at Lizard Island, northern Great Barrier Reef, we photographically marked and georeferenced 36 H. fuscopunctata, ranging 1.4–5.1 kg in weight. In broader searches one year later, we recaptured 92% of the animals. Their displacements were comparable among sites and averaged 8.7 m yr−1. None of the movements could be characterised as nomadic; the maximum displacement was 21 m. Contrary to expectations, smaller animals tended to roam further than larger animals (p = 0.025). Our study shows that certain large-bodied sea cucumbers might not displace far over annual timescales. This empirical evidence of home ranging reshapes our understanding of echinoderm mobility and reveals a behaviour that would exacerbate Allee effects at low population densities.
Hyponatremia and other potential markers of ultrasound abnormalities after a first febrile urinary tract infection in children
Authors: González-Bertolín Isabel , Barbas Bernardos Guillermo , García Suarez Leire , López López Rosario , García Sánchez Paula , Bote Gascón Patricia , Calvo Cristina 
Published: August 2023

AbstractUrinary tract infections are the initial manifestation in 30% of urinary tract malformations. Identifying these patients, who could benefit from a specific treatment, is still challenging. Hyponatremia during urinary tract infection has been proposed as a urinary tract malformation marker. We evaluate the prevalence of hyponatremia during febrile urinary tract infections and its association with subjacent urinary tract malformations. We performed a retrospective study of healthy patients under 16 years, diagnosed with a first episode of febrile urinary tract infection, who had undergone blood testing in the acute episode and at least one renal ultrasound during follow-up (January 2014-November 2020). Hyponatremia was defined as (serum sodium ≤ 130 mEq/L). According to imaging findings, we classified patients into three groups: normal kidney ultrasound, mild pelviectasis, and significant urinary tract malformation. We performed logistic regression models to identify independent risk factors for urinary tract malformation and mild pelviectasis. We included 492 patients and 2.8% presented hyponatremia. We identified normal ultrasound in 77%, mild pelviectasis in 10.8%, and urinary tract malformation in 12% of patients. We found an association between mild pelviectasis and hyponatremia [OR 6.6 (CI95% 1.6–26.6)]. However, we found no association between hyponatremia and urinary tract malformation. The parameters that were associated with malformations were presenting a non-E. coli infection, C-reactive-protein levels over 80 mg/L, and bacteremia.Conclusion: Hyponatremia during the first episode of febrile urinary tract infection is present in 2.8% of patients and is associated with mild pelviectasis in imaging. However, hyponatremia does not indicate a greater need for complementary tests to screen for urinary tract malformations.

What is Known:• Urinary tract infection is the first manifestation in 30% of children with urinary tract malformation.• Hyponatremia could be a marker to identify these children and guide the imaging approach.

What is New:• Around 12% of children with a first episode of febrile urinary tract infection have a urinary tract malformation.• Non-E. coli infection, C-reactive protein levels over 80 mg/L, and bacteremia are markers for malformations to guide diagnostic imaging tests, but hyponatremia (Na ≤ 130 mEq/l) is not a reliable marker.