bluuebunny/crossref_metadata_2025_split huggingface dataset:
Crow Search Algorithm Based on Information Interaction for Epistasis Detection
Authors: Zhang Yaxuan , Shang Junliang , Gu Yijun , Guan Boxin , Ren Qianqian , Ge Daohui , Sun Yan 
Published: March 2023

Abstract

Background:In the genome-wide association study, the interactions of single nucleotide polymorphisms (SNPs) play an important role in revealing the genetic mechanism of complex diseases, and such interaction is called epistasis or epistatic interactions. In recent years, swarm intelligence methods have been widely used to detect epistatic interactions because they can effectively deal with global optimization problems.Results:In this study, we propose a crow search algorithm based on information interaction (FICSA) to detect epistatic interactions. FICSA combines particle swarm optimization (PSO) and crow search algorithm (CSA) to balance the exploration and exploitation in the search process, which can effectively improve the ability of the algorithm to detect epistatic interactions. In addition, opposition-based learning strategy and adaptive parameters are used to further improve the performance of the algorithm. We compare FICSA with other five epistasis detection algorithms on simulated datasets and an age-related macular degeneration (AMD) dataset. The results on simulated datasets show that FICSA has better detection power, while the results on the real dataset demonstrate the effectiveness of the proposed algorithm.Conclusions:The results show that FICSA is better than other methods and can effectively detect epistatic interactions. In addition，FICSA was tested on AMD data, many of the epistatic interactions found have been proved to be related to AMD in the relevant literature. Therefore, FICSA has good performance in epistasis detection.
Decomposing the Gender Pay Gap in Colombia: Do Industry and Type of Worker Matter?
Authors: Lamprea-Barragan Tania Camila , Garcia-Suaza Andres 
Published: March 2023

Abstract
This article aims to quantify to which extent industry and worker characteristics explain the gender pay gap in Colombia. To quantify the role of these factors, we proposed a two-step specification of a counterfactual decomposition method. This specification allows splitting the total gap into the contribution of the employment gender share at the industry level, the demographic composition, and the characteristics’ pay premia. Using Colombian data for 2019 and exploiting the industry and worker type heterogeneity, our findings suggest that the three components are essential to shape the gender pay gap. Despite the pay effect, i.e. what is explained by factors different from socioeconomic characteristics, being the main driver of the gender gap, the labor market sorting is also relevant. The most feminized industries contribute more to enlarge the gender gap, mainly among self-employed workers who have a higher gap that combines wage discrimination and premium gaps and relates to temporal flexibility and unpaid work. Finally, using simulations we show that the proposed two-step decomposition method allows the identification of the relevant components and avoids biases that might result from traditional decomposition methods.
JEL code: J16, J31, J24.
IL-7 promotes CD19-directed CAR-T cells proliferation through miRNA-98-5p by targeting CDKN1A
Authors: Hou Zongliu , Yang Lirong , Li Lin , Meng Mingyao , Li Tiantian , Zhao Yiyi , Yang Songlin , Gao Hui , Tang Weiwei , Yang Yang , Yang Lili , Wang Wenju , Liao Liwei 
Published: March 2023

Abstract
CAR-T targeting CD19 have achieved significant effects in the treatment of B-line leukemia and lymphoma. However, the treated patients frequently relapsed and could not achieve complete remission. Therefore, improving the proliferation and cytotoxicity of CAR-T cells, reducing exhaustion and enhancing infiltration capacity are still issues to be solved. The IL-7 has been shown to enhance the memory characteristics of CAR-T cells, but the specific mechanism has yet to be elaborated. miRNAs play an important role in T cell activity. However, whether miRNA is involved in the activation of CAR-T cells by IL-7 has not yet been reported. Our previous study had established the 3rd generation CAR-T cells. The present study further found that IL-7 significantly increased the proliferation of anti-CD19 CAR-T cells, the ratio of CD4 + CAR + cells and the S phase of cell cycle. In vivo study showed that IL-7-stimulated CAR-T possessed stronger tumoricidal efficiency. Further we validated that IL-7 induced CAR-T cells had low expression of CDKN1A and high expression of miRNA-98-5p. Additionally, CDKN1A was associated with miRNA-98-5p. Our results, for the first time, suggested IL-7 could conspicuously enhance the proliferation of CAR-T cells through miRNA-98-5p targeting CDKN1A expression, which should be applied to CAR-T production.
Development of Optimal Sizing System for Tactical Gloves Applying Empirical Loss Coefficient Ratio
Authors: Hong Yujin , Choi Hee Eun 
Published: March 2023

Abstract
This study aims to improve soldiers' mission performance and protect them from safety accidents by establishing an optimal sizing system that considers the fit of the tactical gloves and the efficiency of production and supply. First, the wearing condition of tactical gloves was investigated through in-depth interviews and surveys. The optimal glove fit and loss coefficient ratio was then analyzed through a glove size selection experiment. Finally, the sizing system was optimized and verified by comparing the coverage rate to the current sizing system. Results indicated that the empirically derived loss coefficient ratio was 0.075 and the optimal sizing system for tactical gloves was S-hand length: 168, hand width: 81, M-hand length: 177, hand width: 83, L-hand length: 184, hand width: 86, XL-hand length: 191, hand width: 89, respectively. The coverage rate of the optimal sizing system proposed in this study was 86.4%, showing an improvement of approximately 21.1% compared to the current sizing system (65.3%). In conclusion, the optimal sizing system for tactical gloves proposed in this study can be a realistic solution, as it improved the coverage rate by 21.1% without incurring additional costs for production or hindering the efficiency of supply.
High sensitivity and wide response range artificial synapse based on polyimide with embedded graphene quantum dots
Authors: Kou Lijie , Ye Nan , Waheed Anjam , Auliya Rahmat Zaki , Wu Chaoxing , Ooi Poh Choon , Li Fushan 
Published: March 2023

Abstract
Artificial electronic synapses are commonly used to simulate biological synapses to realize various learning functions, which is regarded as one of the key technologies in the next generation of neurological computation. In this work, a simple solution spin coating technique prepared memristors based on the simple structure of polyimide (PI):graphene quantum dots(GQDs). The devices exhibit remarkably stable exponentially decaying postsynaptic suppression current over time, as interpreted in the spike-timing-dependent plasticity phenomenon. Furthermore, with the increase of the applied electrical signal over time, the conductance of the electrical synapse gradually changes, and the electronic synapse also shows plasticity dependence on the amplitude and frequency of the pulse applied. In particular, the devices with the structure of Ag/PI:GQDs/ITO prepared in this study can produce a stable response to the stimulation of electrical signals between millivolt to volt, not only showing high sensitivity but also a wide range of “feelings”, which makes the electronic synapses take a step forwards to emulate biological synapses. Meanwhile, the electronic conduction mechanisms of the device are also studied and expounded in detail. The findings in this work lay a foundation for developing brain-like neuromorphic modeling in artificial intelligence.
Quantification of soil organic carbon stocks in Nepal's forests
Authors: Khanal Shiva , Boer Matthias M. , Nolan Rachael H. , Medlyn Belinda E. 
Published: March 2023

Abstract
Comprehensive forest carbon accounting requires reliable estimation of soil organic carbon (SOC) stocks. Despite being an important carbon pool, limited information is available on SOC stocks in global forests, particularly for forests in mountainous regions, such as the Central Himalayas. To address this knowledge gap, we implemented a comprehensive study to accurately estimate forest SOC stocks across Nepal. Our method involved modelling plot-based estimates of forest SOC using covariates related to climate, soil, and topographic position. Our quantile random forest model resulted in the most accurate prediction to date of Nepal's national forest SOC stock together with prediction uncertainties. Our findings were not only spatially explicit but also revealing high SOC levels in high-elevation forests and a significant underrepresentation of these stocks in global-scale assessments. Our results offer an improved baseline for monitoring of the distribution and changes of total carbon in the forests of the Central Himalayas. The benchmark maps of predicted forest SOC and associated errors, along with our estimate of 494 million tonnes (SE = 16) of total SOC in the topsoil (0-30 cm) of forested areas in Nepal, carry important implications for understanding the spatial variability of forest SOC in mountainous regions with complex terrains.
Effective natural inhibitors targeting LSD1 by computational study
Authors: Wang Xinyu , Lin Liangxin , Zhou Pengcheng , Yang Qifan , Jiang Ye , Yang Yilin , Zhu Dong 
Published: March 2023

Abstract
Objective: This study aimed to screen lead compounds and drug candidates with an inhibitory effect on the function of LSD1 from the ZINC database.
Methods: We used computer-aided virtual technology to screen some agents that inhibit the function of LSD1. Initially, LibDock screened out some optimal compounds for docking with LSD1. These candidate compounds were subjected to ADME analysis (adsorption, distribution, metabolism, and excretion) and toxicity metrics. Molecular docking can determine the binding affinity between LSD1 and the ligand, and lastly, we applied molecular dynamics simulations to calculate the docking of the ligand-receptor complex.
Results: Two natural compounds, ZINC000001651126 and ZINC000000001083, found in the ZINC database, are potent inhibitors of LSD1. When ZINC000001651126 and ZINC000000001083 bind to LSD1, they show high binding affinity. They are not hepatotoxic and have a high tolerance to cytochrome P4502D6. In addition, ZINC000001651126 and ZINC000000001083 have less developmental toxicity potential, rodent carcinogenicity, and Ames mutagenicity.
Conclusions: ZINC000001651126 and ZINC000000001083 can be considered safe and ideal drug candidates for LSD1 inhibitors. This study can provide new ideas for future research and the application of LSD1 inhibitors.
Relating community capacity to the adoption of an evidence-based prevention strategy: a community-level analysis
Authors: Birgel Vera , Walter Ulla , Röding Dominik 
Published: March 2023

Abstract
Background: In community-based prevention, adopting an evidence-based strategy is known to predict prevention success. Evidence-based prevention includes a theoretical framework, empirical assessment of prevention needs, use of tested and effective prevention programs, monitoring of community prevention efforts and outcomes, and integration of practice experiences. Also known is that adopting evidence-based prevention requires community capacity. However, it is unclear which domains of community capacity are most important for the adoption of evidence-based prevention. This study aims to examine the extent to which specific capacity domains explain variation in evidence-based prevention.
Methods: The present study is a secondary data analysis based on a survey of 182 key informants in 38 communities. To determine the validity of the measurement, structural validity, internal consistency, and inter-rater agreement were assessed. Associations between adoption of evidence-based prevention and ten domains of community capacity (participation, knowledge & skills, resources, leadership, community power, collaboration consisting of prevention collaboration and sectoral-collaboration, sense of community, critical awareness & problem solving, and community structure) were investigated at the community level using logistic regression models.
Results: Regarding the validation analyses, most findings indicate that the ten community capacity domains could be reliably measured using key informant reports. Results of logistic regression models indicate that adopting evidence-based prevention is related to increased sense of community (OR 6.62; 95 % CI 2.39-18.39), prevention collaboration (OR 26.05; 95 % CI 5.98-13.39), sectoral-collaboration (OR 10.49; 95 % CI 4.04-27.25), community power (19.29; 1.74-28.12), and community structure (OR 4.79; 95 % CI 1.85-12.43). Availability of leadership was predictive of higher chances of adopting evidence-based prevention (OR 5.21; 95 % CI 1.93-14.02).
Conclusion: Our findings suggest that communities with higher community capacity have increased chances of adopting an evidence-based prevention strategy.
MSCT Analysis and Identification of Remarkable Anatomical Types of Segmental Bronchi in R ight Middle Lobe: Based on Extensive Data
Authors: Javed Saeed , Zhang Yi , Wan Dian , Mei Yixuan , Liu Hailan , Liu Cheng , Liu Shuwei 
Published: March 2023

Abstract
Purpose: To evaluate the various branching patterns of segmental bronchi in the right middle lobe and to survey the anatomical diversity and sex-related differences of these branches in a large sample of the study population.
Materials and Methods: In this retrospective board-approved study with informed consent, 10,000 participants (5428 males, mean age 50+/-13.5 years[SD] years; age range: 3-91 years) who underwent multi-slice CT scans from September 2019 to December 2021 were retrospectively included. The data were applied to generate 3D and virtual bronchoscopy (VB) simulations of a bronchial tree using the syngo.via post-processing workstation. The reconstructed images were then interpreted to locate and classify distinct bronchial patterns in right middle lobe. Cross-tabulation analysis and the Pearson chi-square test were used to calculate the constituent ratios of bronchial branch types and determine their significance between male and female groups.
Results: Our results revealed that the segmental bronchial ramifications of the right middle lobe were classified into two types mainly, i.e., bifurcation (B4, B5, 91.42%) and trifurcation (B4, B5, B*, 8.58%). There were no significant sex-related differences in the proportion of bronchial branches in RML (P>0.05).
Conclusion: The current study has confirmed the presence of segmental bronchial variations in the right middle lobe using 3D reconstruction and virtual bronchoscopy. These findings may have significant implications for the diagnosis of symptomatic patients and for carrying out specific procedures like bronchoscopy, endotracheal intubation, and lung resection.
Perillaldehyde mitigates ionizing radiation-induced intestinal injury by inhibiting ferroptosis via the Nrf2 signaling pathway
Authors: Tang Lin-Feng , Xie Li-Wei , Zhou Hao , Ma Xiaoming , Li Ming 
Published: March 2023

Abstract
The gastrointestinal tract is a rapidly self-renewing system and is thus highly sensitive to ionizing radiation (IR). Unfortunately, methods for preventing and treating IR-induced gastrointestinal syndrome are limited. Volatile monoterpenoid perillaldehyde (PAH) is the major component of the essential oil extracted from perilla plants and has been demonstrated to have antioxidant, anti-inflammatory, antimicrobial activity, and antitumor effects. However, its role in preventing or alleviating radiation-induced injuries remains unknown. In this study, PAH prolonged the survival time and attenuated radiation-induced intestinal injury in whole abdominal lethally irradiated mice. PAH treatment also promoted the survival of crypt cells, attenuated radiation-induced DNA damage, and mitigated intestinal barrier damage in irradiated mice. The radioprotective effects of PAH in intestinal crypt organoids and human intestinal epithelial cell line (HIEC-6) were also identified. PAH-mediated radioprotection was associated with the upregulation of Nrf2, activation of the antioxidant pathway, and inhibition of ferroptosis. Notably, treatment with the Nrf2 inhibitor ML385 abolished the protective effects of PAH, indicating that Nrf2 activation is essential for PAH activity. The findings of this study collectively suggest that PAH is a promising therapeutic strategy for IR-induced intestinal injury.
ERAS in Tonsil Adenoid Surgery in Children
Authors: Huang Zuofeng , Sun Ruifang , Liu Fei , Zhang Lue , Liang Junyi , Lu Hui , Zhao Zhimin 
Published: March 2023

Abstract

Backgroud: Enhanced Recovery after Surgery (ERAS) is more and more widely used in pediatric surgery.
Objective: ERAS is more and more widely used in pediatric surgery. Studies on the application of ERAS in tonsil adenoid surgery in children are still insufficient.
Methods: We retrospectively analyzed 314 pediatric patients who underwent simultaneous tonsillar and adenoid resection between January 2018 and March 2022 in our hospital. Results: 190 people (122 males and 68 females) were included in the ERAS group. 89 patients (59 males and 30 females) were included in the control group.
Results: There were no significant differences between the two groups in terms of the basic data age, gender and height, and weight status. There was no statistical difference in anesthetic complications and postoperative complications between the two groups. The length of stay of 5.05 days in the ERAS group was significantly shortened compared with 6.37 days in the control group.
Conclusions: The appropriate time of fasting and drinking before the operation still needs to be further explored and optimized. Early postoperative food intake and nutritional supplementation are also important, especially in patients with eating disorders caused by pain and surgical site infection after pharyngeal surgery such as tonsil surgery.
The ER chaperone, BIP protects Microglial cells from ER stress-mediated Apoptosis in Hyperglycemia
Authors: James Antonisamy William , Bahader Ghaith A. , Albassan Mohammad , Shah Zahoor A. 
Published: March 2023

Abstract
Background: Binding of Immunoglobulin heavy chain protein(BIP) is a major endoplasmic reticulum (ER) chaperone facilitating the assembly of newly synthesized proteins in the ER. Microglial cells vigorously respond to brain injuries and eliminate the damaged neuronal and apoptotic cells through phagocytosis in the central nervous system. However, the mechanism of BIP-mediated microglial cell function is not clear in hyperglycemia. We explored the molecular mechanism of BIP in microglial function during hyperglycemia conditions.
Methods: Hyperglycemia was induced in C57BL/6J mice by two consecutive intraperitoneal injections of streptozotocin (STZ 100/kg) and confirmed by measuring the blood glucose from day 2 to day 14. After 14 days of experimental condition, mice were sacrificed, brains were collected, and tissue lysate was prepared for ER chaperone studies. In-vitro hyperglycemia was induced by exposing HMC3 cells to 25mM glucose for 5 days and proteins involved in ER stress, apoptosis, and autophagy were analyzed. For the BIP induction, cells were treated with 25μM of BIX (BiP inducer-X) after 48 hr of hyperglycemia for 3 days.
Results: In hyperglycemia condition, the major ER chaperone BIP protein expression was dramatically reduced in HMC3 cells, which led to increased apoptosis through the activation of CHOP and mitochondrial pro-apoptotic proteins (Bax, Bad, cleaved caspase-3). The flow cytometry results also indicate that hyperglycemia-induced the apoptosis and reactive oxygen species (ROS) production. Interestingly, the BIP inducer BIX restored the apoptosis in microglia cells through the derepression of BIP expression and inhibition of ER stress.
Conclusion: These results suggest that the ER chaperone BIP is required for the microglial function and protection from apoptosis in hyperglycemia. A better understanding of the molecular mechanism and role of BIP in microglia function may contribute to the development of novel therapies for microglia dysfunction-associated neurodegenerative diseases.
Comparative population genetics of habitat-forming octocorals in two marine protected areas: eco-evolutionary and management implications
Authors: Horaud Mathilde , Arizmendi-Meija Rosana , Nebot-Colomer Elisabet , López-Sendino Paula , Antunes Agostinho , Dellicour Simon , Viard Frédérique , Leblois Raphael , Linares Cristina , Garrabou Joaquim , Ledoux Jean-Baptiste 
Published: March 2023

Abstract
Current efforts to halt the decline of biodiversity decline are based primarily on protecting species richness. This narrow focus overlooks key components of biological diversity, particularly the infra-species genetic diversity, which is critical to consider with respect to genetic adaptation in changing environments. While comparative population genetics is recognized as a relevant approach to improve biodiversity management, it is still barely considered in practice. Here, a comparative population genetics study was conducted on two key habitat-forming octocoral species, Corallium rubrum and Paramuricea clavata, to contribute to management of two Marine Protected Areas (MPAs) in the northwestern Mediterranean. Contrasting patterns of genetic diversity and structure were observed in the two species, although they share many common biological features and live in similar habitats. Differential genetic drift effects induced by species-specific reproductive strategies and demographic histories most likely explain these differences. The translation of our results into management strategies supports the definition of four management units. We identified a coldspot of genetic diversity, with genetically isolated populations, and a hotspot of genetic diversity that has a central role in the system’s connectivity. Interestingly, they corresponded to the most recent and the oldest protected areas, respectively. This case study shows how moving from a“species pattern” perspective to an “eco-evolutionary processes” perspective can help assess and contribute to the effectiveness of biodiversity management plans.
Resolving the soluble-to-toxic transformation of amyloidogenic proteins: A method to assess intervention by small-molecules
Authors: Ahlawat Jyoti , Wilson Daisy L. , Carreon Ana , Narayan Mahesh 
Published: March 2023

Abstract
The soluble-to-toxic transformation of intrinsically disordered amyloidogenic proteins such as amyloid beta (Aβ), α-synuclein, mutant Huntingtin Protein (mHTT) and islet amyloid polypeptide (IAPP) among others is associated with disorders such as Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD) and Type 2 Diabetes (T2D), respectively. Conversely, the dissolution of mature fibrils and toxic amyloidogenic intermediates including oligomers remains the holy grail in the treatment of neurodegenerative disorders. Yet, methods to effectively, and quantitatively, report on the interconversion between amyloid monomers, oligomers and mature fibrils fall short. For the first time, we describe the use of gel electrophoresis to address the transformation between soluble monomeric amyloid proteins and mature amyloid fibrils. The technique permits rapid, inexpensive and quantitative assessment of the fraction of amyloid monomers that form intermediates and mature fibrils. In addition, the method facilitates the screening of small molecules that disintegrate oligomers and fibrils into monomers or retain amyloid proteins in their monomeric forms. Importantly, our methodological advance diminishes major existing barriers associated with existing (alternative) techniques to evaluate fibril formation and intervention.