bluuebunny/crossref_metadata_2025_split huggingface dataset:
A comparison of the effects of melatonin and bisphenol A on the behavior of motile zooxanthellae
Authors: Jones Austin , Martinez Lynell , Garrido Lisa 
Published: April 2023

Bisphenol A (BPA) is classified as an organic chemical pollutant and has received global concern due to its widespread presence in the world’s ocean at relevant environmental concentrations as well as its various negative toxicological and reproductive effects. Endocrine disruption suggests that BPA may compete with hormone receptors involved in cell communication.
Melatonin is an indoleamine produced by many cnidarian species as well as some dinoflagellates. It is a natural neurotransmitter involved in processes such as movement, sexual maturation, metamorphosis, and reproduction.
Research by Ann Tarrant and others suggest that both substances play a role in cell signaling and communication and could be influencing the symbiosis between corals and zooxanthellae. It also proposes that melatonin and BPA share a competitive relationship in vertebrates, with melatonin lowering rates of BPA-induced proliferation of breast cancer cells.
This study aimed to examine the roles and relationships of BPA and melatonin in zooxanthellae, to better understand cell signaling and behavior in dinoflagellates, and explore the similarities and differences in these processes to other marine invertebrates as well as terrestrial vertebrates.
It found negative behavior in zooxanthellae at 100 parts per million BPA and determined that the endocrine-like signal transduction in some dinoflagellates and vertebrates is alike because melatonin and BPA share a competitive relationship in both. It is possible that BPA could be interfering with inter- and intraspecies signaling in marine organisms. Because of these findings, the presence of BPA in high concentrations in the ocean could be devastating to the world’s coral reefs.
Antropologia, Educação Física e Saúde Coletiva: aproximações interdisciplinares
Authors: Ferreira Jaqueline , Silva Alan Camargo , Souza Mayara Cassimira de 
Published: April 2023

O presente trabalho visa abordar as aproximações entre Antropologia e Educação Física que se encontram na formação em Saúde coletiva. Nesse aspecto a interdisciplinaridade é essencial para a renovação de temáticas e incorporação de novos conceitos. O ponto de confluência dessas áreas é o estudo do corpo e da saúde. O corpo interessa a essas áreas não somente por seus aspectos biológicos e intervenções biomédicas, mas por ser uma expressão de sentimentos, discursos e práticas emblemáticos de processos sociais. Essa discussão intenta contribuir para a formação acadêmica e práxis da Saúde Coletiva sobre os cuidados relativos à saúde corporal.
Pain Experiences of People Diagnosed With Autism Spectrum Disorder: A Systematic Review of Case–Control Studies
Authors: Ortiz Rubio Araceli , de María Romero Ayuso Dulce Nombre , Torres Sánchez Irene , Cabrera Martos Irene , Rodríguez Torres Janet , López López Laura , Valenza Marie Carmen 
Published: April 2023

AbstractImportance: Autism spectrum disorder (ASD) is one of the most prevalent neurodevelopmental disorders and is characterized by compromised social interactions, reduced verbal communication, stereotyped repetitive behaviors, restricted interests, and sensory abnormalities. Yet absent from the knowledge base is information about sensory abnormalities related to pain experiences. Exploring the pain experiences of people with ASD may provide occupational therapy practitioners with a baseline to determine areas of need and effective interventions.Objective: To conduct a systematic review of the literature to summarize current evidence from case–control studies comparing sensory abnormalities with regard to pain experiences of people diagnosed and not diagnosed with ASD.Data Sources: A systematic literature search of the CINAHL, Cochrane, MEDLINE (PubMed), OTseeker, and Web of Science databases, using MeSH terms and broad keywords.Study Selection and Data Collection: A search was performed according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The Newcastle–Ottawa Scale was used to evaluate the risk of bias of the included studies.Findings: A total of 27 case–control studies involving 865 people with ASD and 864 control participants were included. Several methods were used to explore pain experiences, such as threshold detection or pain threshold.Conclusion and Relevance: The results indicate that people with ASD may have an abnormal sensory experience with regard to pain sensitivity. Occupational therapy practitioners should develop an intervention to focus on pain.What This Article Adds: This study adds to the body of literature indicating that people with ASD have sensory abnormalities with regard to pain experiences. Results highlight the need for occupational therapy interventions to focus on pain experiences.
Reductions in Depression and Anxiety Among Autistic Adults Participating in an Intervention to Promote Healthy Relationships
Authors: Holmes Laura Graham , Goebel Russell J. , Hollingue Calliope , Zhu Shuning , Zhang Handing , Shan Wuji , Wang Shicong , Caplan Reid , Sanchez Amelia , Wharmby Peter , Chiang Melody , Person Mariah , Rothman Emily F. 
Published: April 2023

AbstractImportance: Some autistic adults experience depression and anxiety related to their social relationships. There is a need for evidence-based occupational therapy interventions that decrease depression and anxiety and improve the health of social relationships for autistic adults.Objective: To determine the feasibility and preliminary effectiveness of the Healthy Relationships on the Autism Spectrum (HEARTS) intervention, a six-session, group-based psychoeducational intervention for the improvement of relationship health.Design: One-group pretest–posttest design with a 3-mo follow-up after baseline.Setting: United States; online intervention through community organization.Participants: Fifty-five adults, ages 20 to 43 yr, with a professional or self-diagnosis of autism and the capacity to independently participate in an online, group-based, participatory class.Intervention: Participants received 6 90-min weekly sessions that addressed healthy relationship topics, including recognizing abuse, meeting people, maintaining relationships, setting interpersonal boundaries, neurohealth for relationships, and ending relationships. A psychoeducational approach that provided education and involved guided discovery and strategy acquisition was used.Outcomes and Measures: All measures were self-administered through an online survey. Depression and anxiety were assessed using instruments from the Patient-Reported Outcomes Measurement Information System.Results: Fifty-five participants completed the intervention. Postintervention scores revealed statistically significant improvements in depression and anxiety.Conclusions and Relevance: HEARTS is a promising intervention for improving depression and anxiety among autistic adults and should be investigated further.What This Article Adds: HEARTS offers a potentially effective, nonpharmacological, psychoeducational group-based intervention option to promote healthy relationships for autistic adults.Positionality Statement: This article uses identity-first language (autistic person) in accordance with the preference of autistic self-advocates (Autistic Self Advocacy Network, 2020; Kenny et al., 2016; Lord et al., 2022).
Optimization studies for extraction of antioxidants from Mucuna sanjappae seeds: A promising natural drug for oxidative stress management
Authors: Patil Ravishankar , Aware Chetan , Vyavahare Govind , Bapat Vishwas , Singh Rajshri , Jadhav Jyoti 
Published: April 2023

Introduction and Aim: Cellular oxidative stress is responsible for various human diseases. Dietary antioxidant supplements from natural plants have good potential to reduce increased oxidative stress thus protecting from further medical complications. Genus Mucuna is well known for its promising health benefits. A common species of Mucuna, M. pruriens is being used for oxidative stress related diseases treatment. However, many species of this genus are not scientifically explored for their health-related beneficial properties. In the present study, we have made effort to investigate secondary metabolites composition and antioxidant potential in a Mucuna species namely M. sanjappae. In this work, we tried to understand superior system for secondary metabolites (total phenolics and flavonoids content) extraction and antioxidant activity in M. sanjappae seeds was demonstrated.

Methodology: Four different solvents viz., water, methanol, ethanol, and acetone in combination with four different extraction conditions (static, shaking, microwave and sonication) each with three different times have been studied. Total 48 extract samples were generated which were used for total phenolics, total flavonoids content along with antioxidant activity (DPPH, DMPD and FRAP) determination. Further major phenolics were identified using HPLC system.

Results: Water showed highest TPC and TFC level during microwave method for 120 seconds (81.627±0.728 mg GAE g-1 and 648.06±4.37 mg RUE g-1 respectively). The highest antioxidant activity was also found in M. sanjappae seeds extracted in water. RP-HPLC quantification of phenolics revealed tannic acid and gallic acid as predominant compounds. Correlation analysis indicated that the antioxidant of different extracted samples demonstrated a good positive relationship with TPC and TFC.

Conclusion: Present attempt indicated that, simple solvent water along with microwave method can be used for maximum antioxidants extraction from M. sanjappae seeds. This Mucuna species may be further studied to exploit as a natural antioxidant source in medicine and food etc.
The factors affecting optimisation of phytosynthesis of silver nanoparticles using Indian medicinal plant species and their biological applications: A review
Authors: Sikdar Sima , Sikdar (nee Bhakta) Mausumi 
Published: April 2023

Recently, silver nanoparticles (AgNPs) hold a centre stage in the vast arena of research in nanomedicine. Biological methods of synthesis of nanoparticles are being adopted to avoid the use of chemicals that are toxic and hazardous and used in chemical synthetic methods. The choice of the plant extracts used for the synthesis of AgNPs is based on their phytochemicals and pharmaceutical properties. Another importance of the phytosynthesis method is that it is simple, easy, fast, reliable and cost effective. The phytochemical components of the herbal extracts not only cause reduction of Ag+1 to Ag0, but also increase the biological activities of the nanoparticles. This article briefly describes the research on green synthesis of AgNPs using Indian medicinal plant extracts. We aim to provide a systemic depth of information regarding the effect of various reaction factors during the synthesis of AgNPs such as the concentration of silver salt and phytoextract, light intensity, time, temperature, pH of the reaction mixture. The characterizations of nanoparticles are done by X-ray diffraction, ultraviolet- visible spectroscopy, Fourier-transform infrared spectra, transmission electron microscopy, dynamic light scattering and zeta potential analysis. The phytochemicals and pharmaceutical activities present in the plant extracts are also reported here. The articles from 2011 to 2022 were selected and studied in detail to get in-depth knowledge about the phytosynthesis of AgNPs and their biological activities.
Study of some physiological and hematological parameters in obese women with arthritis
Authors: Abdul Hussein Jabbar Maryam , Khidhair Hussain Zainab 
Published: April 2023

Introduction and Aim: Obesity and overweight refers to excessive buildup of fat in the body. Arthritis is a group of medical disorders associated with obesity and being overweight. Obesity associated with rheumatoid arthritis is more pronounced in women. In this study, we aimed to evaluate some physiological and hematological parameters in obese women with arthritis.

Materials and Methods: This study included 90 women aged between 18 and 68 years. The women were divided into three groups based on their BMI as Obese (n=30), Obese+RA (n=30) and normal lean women as controls (n=30). Blood drawn from each participant was tested for their complete blood tests, lipid profiles, C-reactive protein reaction and presence of rheumatoid factor. Data was subjected to statistical analysis.

Results: Our study revealed the mean +SE for age, WHR and BMI to be elevated in women in the obese as well as Obese+RA groups and to be significantly higher in comparison to women in the control group. Except for HDL, all the other lipid parameters were seen elevated in the obese and Obese+RA group and showed significant difference from the control group. Similarly, among the complete blood count indices only ESR, WBC and PLT were found to be significantly elevated in obese and Obese+RA groups. The prevalence percentage for CRP and RF was seen to be highest in individuals belonging to the Obese+RA group.

Conclusion: Obese women as well as obese women with RA have elevated hematological and physiological parameters when compared to lean women.
Investigations into Nolvadex toxicity on the kidneys of albino male rats: Physiological and histopathological study
Authors: Fayadh Sameer Adnan , Abdulsalam Kader Marwa , Sallih Hallab Noor , Hadi Saleh Tahreer 
Published: April 2023

Introduction and Aim: Breast cancer is the most prevalent sex-based malignancy worldwide. Nolvadex is commonly used as first-line therapy for patients with breast cancer. However, studies have indicated that long-term usage of this medicine can result in nephrotoxicity, which can damage kidney tissues. So, the aim of this research was to examine what happened to the serum levels of urea, uric acid, and creatinine when the drug was given to rats in a range of different doses.

Materials and Methods: Male Wistar rats (n=40) were randomly divided into four groups (n=10 each). The physiological solution (normal saline, 0.9%) was given to the control group (G1). Rats in Groups 2, 3, and 4 received Nolvadex at dosages of 30, 40, and 50 mg/kg of body weight four times weekly for a total of 10 weeks. At the end of the experimental period blood drawn from these animals were checked for serum concentrations of urea, uric acid, and creatinine. The animals were sacrificed and their kidneys subjected to histopathological examination. Data obtained was subjected to statistical analysis.

Results: The levels of urea, uric acid, and creatinine that were discovered in the experimental groups were all determined to be significantly higher than the levels that were discovered in the control group. In the experimental group that was given Nolvadex, an infiltration of inflammatory cells, blood congestion, pyknic and necrotic nuclei in the glomerulus, substantial epithelial deterioration in the renal tubules, and an altered renal tissue architecture were detected.

Conclusion: Serum levels of urea, uric acid and creatinine levels increased when experimental rats were administered with varying concentration of the drug Nolvadex. Its administration caused alteration to the architecture of renal tissue.
Días de vino y vasos: mujeres y fiesta en la cer´ámica ática de figuras rojas
Authors: Díez Platas Fátima 
Published: April 2023

Esta contribución pretende proponer una mirada interpretativa a las escenas representadas en el conjunto de estamnos áticos de figuras rojas de mediados del siglo V a. C. que se encuadran dentro de los conocidos como “vasos de las Leneas”. La lectura que se propone tiene en cuenta los análisis y las interpretaciones del grupo de vasos realizados desde el primer trabajo de Frickenhaus (1912) que estableció el corpus de estudio e introdujo la debatida cuestión de la identificación de las escenas como representación de la fiesta ateniense de las Leneas. Dejando de lado el debate de la identificación concreta de la fiesta en la puesta en escena figurativa de un conjunto de imágenes de indudable corte dionisiaco e identificable tono ciudadano, la propuesta interpretativa se centra en los protagonistas de las escenas -los vasos y las mujeres-, en la relación entre los elementos figurativos y en el modo de representación y narración visual para intentar desentrañar un tipo de escena dionisiaca encuadrada en una clase determinada de vasos con unos destinatarios concretos.
John Walton’s Invention of the Iambic Pentameter
Authors: Myklebust Nicholas 
Published: April 2023

ABSTRACT
When Geoffrey Chaucer died in 1400, the decasyllable he invented in the late 1370s and raised to prominence in the 1380s and 1390s lay precariously in the hands of scribes and rivals. Of the poets to reform Chaucer’s meter in the first decade of the fifteenth century, John Walton devised the subtlest and most successful alternative to the inherited decasyllable, capitalizing on the full range of formal and grammatical ambiguities in Chaucer’s line and turning them from bugs into features, in an expanding program of new candidate meters. His revision of the decasyllable in De Consolatione Philosophiae (ca. 1410), a verse translation of Boethius and veiled satire on Chaucer’s Boece, uses the decasyllabic resource to fill several vacancies in the scramble for authority following Chaucer’s death.
The Elusive Transformation of Alliterative Meter
Authors: Weiskott Eric 
Published: April 2023

ABSTRACT
That Old English meter evolved directly into Middle English alliterative meter is a newly won consensus position among metrical specialists. Exactly how it did so remains elusive. The changes, at the level of metrical patterning, are few yet far-reaching, transforming a meter in mirrored half-lines of four metrical positions apiece into a long-line meter with asymmetry between its halves. This essay fills in further details, taking up the challenge to infer from surviving texts how one state of a metrical system slowly became another. Specifically, it is argued that four difficult elements in Old English meter guided metrical evolution. Metrical resolution, the conflicted treatment of verbal prefixes, rare verses of five metrical positions, and a special extended metrical style known as hypermeter pulled against the four-position framework of Old English meter and accelerated and directed metrical change.
Sector-level economic effects of regulatory complexity: evidence from Spain
Authors: Mora-Sanguinetti Juan S. , Quintana Javier , Soler Isabel , Spruk Rok 
Published: April 2023

This paper studies for the first time the impact on various measures of economic efficiency of regulatory complexity by sector in Spain. We base our analysis on an innovative database that classifies 206,777 regulations by economic sector and region, which highlights the growing volume of regulation, as well as its diversity by sector, region and business cycle stage.
This analysis first looks at the aggregate impacts of sectoral regulatory complexity on the employment-to-population ratio, total working hours, sectoral GDP shares, labour intensity and capital intensity. Secondly it delves into the heterogeneous impacts observed across firms of different sizes and ages, drawing on the MCVL (Continuous Work History Sample), a rich database at the enterprise level.
On the first front, we estimate a set of multiple fixed-effects model specifications across 13 economic sectors, 23 regulatory sectors and 17 Spanish regions over the period 1995-2020. Our results suggest that greater regulatory complexity has a negative impact on the employment rate and on value added. The effect on employment is consistent with previous findings for the United States. In particular, ceteris paribus, each additional increase in the regulatory complexity index is associated with a 0.7 percent drop in the sector-level employment share. Furthermore, our findings suggest that several distortionary sector-level effects of increasing regulatory complexity are taking place. For instance, markedly lower labour intensity and decreased sector-level investment rates, which confirm that greater regulatory complexity entails non-trivial sector-level costs. Distortionary effects of regulatory complexity materialise through compositional differences, mainly in the form of reduced wages and a lower investment rate.
O GÊNERO DISCURSIVO MEMÓRIAS LITERÁRIAS: UMA ANÁLISE DE MEMÓRIAS DE LIVROS DE JOÃO UBALDO RIBEIRO SOB A PERSPECTIVA PERSPECTIVA BAKHTINIANA
Authors: Silva Helenice Farias de Brito , Ferreguett Cristhiane , Ferreguett Cristhiane 
Published: April 2023

O presente artigo apresenta uma investigação sobre a escrita do gênero discursivo memórias literárias, sua a função social e as características linguístico-discursivas sob a perspectiva de análise dialógica bakhtiniana. Além disso, esse estudo sinaliza as marcas que definem a materialidade do gênero, utilizando, para isso, o texto Memória de livros, de João Ubaldo Ribeiro. O aporte teórico utilizado é a teoria bakhtiniana, com ênfase em língua, linguagem e gêneros discursivos. Após isto, nos detemos à orientação metodológica apresentada por Bakhtin (2000, 2016), Volóchinov (2017) e Medviédev (2012), e sua aplicação ao gênero escolhido. Subsidiam nosso trabalho, além dos estudos desenvolvidos por Bakhtin (2000, 2004) e Volóchinov (2017), também as obras de Clara, Altenfeder e Almeida (2010), Lima (2009), entre outros. A partir da pesquisa realizada, chegamos à conclusão que os gêneros discursivos são instrumentos mediadores de ações sociais para fins de interação, construídos por entidades ativas e participantes do mundo das interações sociais.
FREQUENCY OF SIGNIFICANT CORONARY ARTERY DISEASE IN CASES WITH ST SEGMENT DEPRESSION DURING RECOVERY PHASE OF EXERCISE
Authors: FAROOQ U , ULLAH N , QURESHI AE , SAJJAD M , ANUM H , DAR WA 
Published: April 2023

Coronary Artery Disease (CAD) imposes physical, social, and economic burden. It is amongst the leading causes of mortality and morbidity. Exercise-induced ST segment depression is considered reliable ECG finding for the diagnosis of obstructive coronary atherosclerosis. Exercise testing has an excellent safety record. The aim of the study is to determine the frequency of significant coronary artery disease in cases with ST-segment depression during recovery phase of exercise tolerance test. This descriptive case series was carried out at the Department of Cardiology, Rehmatul-Lil-Alamin Institute of Cardiology, Lahore, from 11-01-2021 to 10-07-2021. A total of 89 patients were taken in this study. Conventional coronary angiography via femoral or radial route was performed. Lesions were quantified by QCA technique in addition to visual assessment. Significant CAD was labelled as per operational definition. Patients ranged between 30-70 years of age with mean age of 51.8±10.8 years. There were 56 males (62.9%) while remaining 33 (37.1%) were females. History of diabetes mellitus was reported in 31 patients (34.8%), hypertension in 38 patients (42.7%) and smoking 51 (57.3%). Family history of CAD found in 46 patients (51.7%). Hyperlipidemia reported in 38 patients (42.7%). Significant CAD was observed in 76 patients (85.4%). Stratification for age, gender, diabetes mellitus, hypertension and smoking were carried out and found no association with significant CAD. In conclusion, 85.4% frequency rate of significant coronary artery disease in cases with ST segment depression during recovery phase of exercise tolerance test was observed. Thus, careful evaluation of ST segment depression occurring in recovery phase may add significantly to the clinical information derived from the results of ETT.