bluuebunny/crossref_metadata_2025_split huggingface dataset:
General cross-modality registration framework for visible and infrared UAV target image registration
Authors: Luo Yu , Cha Hao , Zuo Lei , Cheng Peng , Zhao Qing 
Published: August 2023

AbstractIn all-day-all-weather tasks, well-aligned multi-modality images pairs can provide extensive complementary information for image-guided UAV target detection. However, multi-modality images in real scenarios are often misaligned, and images registration is extremely difficult due to spatial deformation and the difficulty narrowing cross-modality discrepancy. To better overcome the obstacle, in this paper, we construct a General Cross-Modality Registration (GCMR) Framework, which explores generation registration pattern to simplify the cross-modality image registration into a easier mono-modality image registration with an Image Cross-Modality Translation Network (ICMTN) module and a Multi-level Residual Dense Registration Network (MRDRN). Specifically, ICMTN module is used to generate a pseudo infrared image taking a visible image as input and correct the distortion of structural information during the translation of image modalities. Benefiting from the favorable geometry correct ability of the ICMTN, we further employs MRDRN module which can fully extract and exploit the mutual information of misaligned images to better registered Visible and Infrared image in a mono-modality setting. We evaluate five variants of our approach on the public Anti-UAV datasets. The extensive experimental results demonstrate that the proposed architecture achieves state-of-the-art performance.
Geothermal and structural features of La Palma island (Canary Islands) imaged by ambient noise tomography
Authors: Cabrera-Pérez Iván , Soubestre Jean , D’Auria Luca , Barrancos José , Martín-Lorenzo Alba , van Dorth David Martínez , Padilla Germán D. , Przeor Monika , Pérez Nemesio M. 
Published: August 2023

AbstractLa Palma island is located in the NW of the Canary Islands and is one of the most volcanically active of the archipelago, therefore the existence of geothermal resources on the island is highly probable. The main objective of this work is to detect velocity anomalies potentially related to active geothermal reservoirs on La Palma island, by achieving a high-resolution seismic velocity model of the first few kilometres of the crust using Ambient Noise Tomography (ANT). The obtained ANT model is merged with a recent local earthquake tomography model. Our findings reveal two high-velocity zones in the island’s northern and southern parts, that could be related to a plutonic intrusion and old oceanic crust materials. Conversely, four low-velocity zones are imaged in the southern part of the island. Two of them can be related to hydrothermal alteration zones located beneath the Cumbre Vieja volcanic complex. This hypothesis is reinforced by comparing the S-wave velocity model with the seismicity recorded during the pre-eruptive phase of the 2021 Tajogaite eruption, which revealed an aseismic volume coinciding with these low-velocity zones. Another low-velocity zone is observed in the southern part of the island, which we interpret as highly fractured rocks which could favour the ascent of hot fluids. A last low-velocity zone is observed in the central part of the island and associated with loose deposits generated by the Aridane valley mega landslide.
Comparison of angiogenic potential in vitrified vs. slow frozen human ovarian tissue
Authors: Schallmoser Andreas , Einenkel Rebekka , Färber Cara , Hüren Vanessa , Emrich Norah , John Julia , Sänger Nicole 
Published: August 2023

AbstractVitrification of ovarian tissue is a promising alternative approach to the traditional slow freezing method. Few empirical investigations have been conducted to determine the angiogenic profiles of these two freezing methods. In this study we aimed to answer the question whether one of the cryopreservation methods should be preferred based on the secretion of angiogenic factors. Tissue culture with reduced oxygen (5%) was conducted for 48 h with samples of fresh, slow frozen/thawed and vitrified/rapid warmed ovarian cortex tissue from 20 patients. From each patient, tissue was used in all three treatment groups. Tissue culture supernatants were determined regarding cytokine expression profiles of angiogenin, angiopoietin-2, epidermal growth factor, basic fibroblast growth factor, heparin binding epidermal growth factor, hepatocyte growth factor, Leptin, Platelet-derived growth factor B, placental growth factor and vascular endothelial growth factor A via fluoroimmunoassay. Apoptotic changes were assessed by TUNEL staining of cryosections and supplemented by hematoxylin and eosin and proliferating cell nuclear antigen staining. Comparing the angiogenic expression profiles of vitrified/rapid warmed tissue with slow frozen/thawed tissue samples, no significant differences were observed. Detection of apoptotic DNA fragmentation via TUNEL indicated minor apoptotic profiles that were not significantly different comparing both cryopreservation methods. Vitrification of ovarian cortical tissue does not appear to impact negatively on the expression profile of angiogenic factors and may be regarded as an effective alternative approach to the traditional slow freezing method.
Rho enhancers play unexpectedly minor roles in Rhodopsin transcription and rod cell integrity
Authors: Sun Chi , Ruzycki Philip A. , Chen Shiming 
Published: August 2023

AbstractEnhancers function with a basal promoter to control the transcription of target genes. Enhancer regulatory activity is often studied using reporter-based transgene assays. However, unmatched results have been reported when selected enhancers are silenced in situ. In this study, using genomic deletion analysis in mice, we investigated the roles of two previously identified enhancers and the promoter of the Rho gene that codes for the visual pigment rhodopsin. The Rho gene is robustly expressed by rod photoreceptors of the retina, and essential for the subcellular structure and visual function of rod photoreceptors. Mutations in RHO cause severe vision loss in humans. We found that each Rho regulatory region can independently mediate local epigenomic changes, but only the promoter is absolutely required for establishing active Rho chromatin configuration and transcription and maintaining the cell integrity and function of rod photoreceptors. To our surprise, two Rho enhancers that enable strong promoter activation in reporter assays are largely dispensable for Rho expression in vivo. Only small and age-dependent impact is detectable when both enhancers are deleted. Our results demonstrate context-dependent roles of enhancers and highlight the importance of studying functions of cis-regulatory regions in the native genomic context.
Near infrared-emitting multimodal nanosystem for in vitro magnetic hyperthermia of hepatocellular carcinoma and dual imaging of in vivo liver fibrosis
Authors: Nazeer Shaiju S. , Saraswathy Ariya , Nimi Nirmala , Santhakumar Hema , Radhakrishnapillai Suma Parvathy , Shenoy Sachin J. , Jayasree Ramapurath S. 
Published: August 2023

AbstractProlonged usage of traditional nanomaterials in the biological field has posed several short- and long-term toxicity issues. Over the past few years, smart nanomaterials (SNs) with controlled physical, chemical, and biological features have been synthesized in an effort to allay these challenges. The current study seeks to develop theranostic SNs based on iron oxide to enable simultaneous magnetic hyperthermia and magnetic resonance imaging (MRI), for chronic liver damage like liver fibrosis which is a major risk factor for hepatocellular carcinoma. To accomplish this, superparamagnetic iron oxide nanoparticles (SPIONs) were prepared, coated with a biocompatible and naturally occurring polysaccharide, alginate. The resultant material, ASPIONs were evaluated in terms of physicochemical, magnetic and biological properties. A hydrodynamic diameter of 40 nm and a transverse proton relaxation rate of 117.84 mM−1 s−1 pronounces the use of ASPIONs as an efficient MRI contrast agent. In the presence of alternating current of 300 A, ASPIONs could elevate the temperature to 45 °C or more, with the possibility of hyperthermia based therapeutic approach. Magnetic therapeutic and imaging potential of ASPIONs were further evaluated respectively in vitro and in vivo in HepG2 carcinoma cells and animal models of liver fibrosis, respectively. Finally, to introduce dual imaging capability along with magnetic properties, ASPIONs were conjugated with near infrared (NIR) dye Atto 700 and evaluated its optical imaging efficiency in animal model of liver fibrosis. Histological analysis further confirmed the liver targeting efficacy of the developed SNs for Magnetic theranostics and optical imaging as well as proved its short-term safety, in vivo.
Production of oyster mushroom (Pleurotus ostreatus) from some waste lignocellulosic materials and FTIR characterization of structural changes
Authors: Akcay Caglar , Ceylan Faik , Arslan Recai 
Published: August 2023

AbstractIn this study, oyster (Pleurotus ostreatus) mushroom was cultivated from hazelnut branches (HB) (Corylus avellana L.), hazelnut husk (HH), wheat straw (WS), rice husk (RH) and spent coffee grounds (CG). Hazelnut branch waste was used for the first time in oyster mushroom cultivation. In the study, mushrooms were grown by preparing composts from 100 to 50% mixtures of each waste type. Yield, biological activity, spawn run time, total harvesting time and mushroom quality characteristics were determined from harvested mushroom caps. In addition, chemical analysis of lignocellulosic materials (extractive contents, holocellulose, α-cellulose, lignin and ash contents) were carried out as a result of mushroom production and their changes according to their initial amounts were examined. In addition, the changes in the structure of waste lignocellulosic materials were characterized by FTIR analysis. As a result of the study, 172 g/kg yield was found in wheat straw used as a control sample, while it was found as 255 g/kg in hazelnut branch pruning waste. The highest spawn run time (45 days) was determined in the compost prepared from the mixture of hazelnut husk and spent coffee ground wastes. This study showed that HB wastes can be used for the cultivation of oyster mushroom (P. ostreatus). After mushroom cultivation processes, holocelulose and α-cellulose content rates decreased while ash contents increased. FTIR spectroscopy indicated that significant changes occurred in the wavelengths regarding cellulose, hemicellulose and lignin components. Most significant changes occurred in 1735, 1625, 1510, 1322 and 1230 wavelengths.
Exogenous epibrassinolide application improves essential oil biosynthesis and trichome development in peppermint via modulating growth and physicochemical processes
Authors: Parrey Zubair Ahmad , Shah Sajad Hussain , Mohammad Firoz , Siddiqui Manzer H. , Alamri Saud , Kalaji Hazem M. 
Published: August 2023

AbstractPeppermint has gained a promising status due to the presence of a high proportion of bioactive compounds, especially menthol. Due to its pharmacological efficacy, the demand for its plant-based bioactive compounds necessitates its cultivation worldwide. Brassinosteroids are polyhydroxylated sterol derivatives that regulate diverse processes and control many agronomic traits during plant growth and development. A factorial randomised pot experiment was performed in the net house to investigate the effect of 24-Epibrassinolide (EBL) on the growth, physiology, essential oil content, stomatal behaviour and trichome development of the three cultivars of peppermint. Four levels of foliage-applied EBL, viz. 0, 10–5, 10–6 and 10–7 M were applied to the three cultivars of peppermint (Kukrail, Pranjal and Tushar). Among the different treatments of EBL, the application of 10–6 M increased shoot length by 38.84, 37.59 and 36.91%, root length by 36.73, 29.44 and 33.47%, chlorophyll content by 24.20, 22.48 and 23.32%, PN by 32.88, 32.61 and 33.61%, EO content by 32.72, 30.00 and 28.84%, EO yield per plant by 66.66, 77.77 and 73.33% and menthol yield per plant by 127.27, 110 and 118.18% in Kukrail, Tushar and Pranjal respectively, compared with their respective control plants. Further, the 10–6 M EBL exhibited improved trichome size and density, cellular viability and menthol content of the oil analysed from scanning electron microscopy, confocal laser scanning microscopy and GC–MS respectively as compared to the control. In conclusion, out of different levels of EBL, two sprays of 10–6 M EBL proved effective in enhancing the morphophysiological features and productivity of mint plants, particularly for cultivar Kukrail.
Chemokine expression predicts T cell-inflammation and improved survival with checkpoint inhibition across solid cancers
Authors: Romero Joan Miguel , Titmuss Emma , Wang Yifan , Vafiadis James , Pacis Alain , Jang Gun Ho , Zhang Amy , Golesworthy Bryn , Lenko Tatiana , Williamson Laura M. , Grünwald Barbara , O’Kane Grainne M. , Jones Steven J. M. , Marra Marco. A. , Wilson Julie M. , Gallinger Steven , Laskin Janessa , Zogopoulos George 
Published: August 2023

AbstractImmune checkpoint inhibitors (ICI) are highly effective in specific cancers where canonical markers of antitumor immunity are used for patient selection. Improved predictors of T cell-inflammation are needed to identify ICI-responsive tumor subsets in additional cancer types. We investigated associations of a 4-chemokine expression signature (c-Score: CCL4, CCL5, CXCL9, CXCL10) with metrics of antitumor immunity across tumor types. Across cancer entities from The Cancer Genome Atlas, subgroups of tumors displayed high expression of the c-Score (c-Scorehi) with increased expression of immune checkpoint (IC) genes and transcriptional hallmarks of the cancer-immunity cycle. There was an incomplete association of the c-Score with high tumor mutation burden (TMB), with only 15% of c-Scorehi tumors displaying ≥10 mutations per megabase. In a heterogeneous pan-cancer cohort of 82 patients, with advanced and previously treated solid cancers, c-Scorehi tumors had a longer median time to progression (103 versus 72 days, P = 0.012) and overall survival (382 versus 196 days, P = 0.038) following ICI therapy initiation, compared to patients with low c-Score expression. We also found c-Score stratification to outperform TMB assignment for overall survival prediction (HR = 0.42 [0.22–0.79], P = 0.008 versus HR = 0.60 [0.29-1.27], P = 0.18, respectively). Assessment of the c-Score using the TIDE and PredictIO databases, which include ICI treatment outcomes from 10 tumor types, provided further support for the c-Score as a predictive ICI therapeutic biomarker. In summary, the c-Score identifies patients with hallmarks of T cell-inflammation and potential response to ICI treatment across cancer types, which is missed by TMB assignment.
Photoinduced activation of alkyl chlorides
Authors: Ji Cheng-Long , Zhai Xinyi , Fang Qing-Yun , Zhu Chengjian , Han Jie , Xie Jin 
Published: August 2023

In this review, photoinduced activation of unactivated alkyl chlorides via single electron transfer strategy, chlorine atom transfer, metallaphotoredox synergistic catalysis, and photoexcited metal catalysis strategies have been discussed.
Mechanical safety of reinforced concrete structures at all stages of the life cycle
Authors: Terekhov Ivan A. , Trekin Nikolay N. , Kodysh Emil N. , Shmakov Sergey D. 
Published: August 2023

Ensuring the mechanical safety of operated buildings at all stages of the life cycle is an urgent task. This is especially important when planning major repairs and reconstruction in buildings, as well as determining the period of safe operation from the moment of the survey, i.e. clarification of the remaining service life.
The total service life at the design stage is set by the customer and the general designer in accordance with the recommendations of GOST 27751-2014 «Reliability for constructions and foundations. General principles». Mechanical safety and durability are ensured when calculating structures using the limit state method, assigning protection measures depending on the operating conditions, as well as complying with the requirements of SP 255.1325800.2016 «Buildings and structures. Operating rules. General Provisions».
A method for preliminary assessment of the mechanical safety of buildings and their structures is proposed for consideration, which eliminates some of the shortcomings of existing methods for calculating the residual life by physical wear (damage) of building structures based on the results of a visual inspection, the basis of which is the dependence of the allowable safe operation period on the percentage of reduced bearing capacity. It is proposed to use the results of a visual inspection performed in accordance with GOST 31937-2011 «Buildings and constructions. Rules of inspection and monitoring of the technical condition».
Cancer Survivors – wie müssen diese Patienten kardiologisch angebunden werden?
Authors: Evertz Ruben , Braulke Friederike , El Shafie Rami A. , von Haehling Stephan 
Published: August 2023

ZusammenfassungDie kardioonkologische Nachsorge von Patienten mit stattgehabter oder anhaltender Tumortherapie umfasst sowohl kardial asymptomatische Patienten, die aufgrund der tumorspezifischen Therapie
ein erhöhtes Risiko besitzen, kardiovaskuläre Ereignisse zu erleiden, als auch Patienten, die bereits manifeste kardiovaskuläre Erkrankungen unter der tumorspezifischen Therapie erlebt
haben. Bei asymptomatischen Patienten mit stattgehabter Anthrazyklin- und/oder mediastinaler Strahlentherapie richten sich der Zeitpunkt der kardiologischen Erstkonsultation sowie das
Intervall der kardioonkologischen Nachbetreuung nach dem individuellen Patientenrisiko und der erhaltenen Bestrahlungs- und Anthrazyklindosis. Die frühe Identifikation von Risikopatienten
und die Erkennung von Spätfolgen einer Krebserkrankung und/oder -therapie stellen interdisziplinäre Herausforderungen dar. Die optimale Therapie und Nachsorge von Cancer Survivors mit
kardiovaskulärem Risiko bedarf einer engen Absprache und Zusammenarbeit aller behandelnden onkologischen und kardiologischen Spezialisten.
Moderation of Physical Activity between Cardiometabolic Risk and
Adiponectin in Adolescents
Authors: Tadiotto Maiara Cristina , Corazza Patricia Ribeiro Paes , Menezes Junior Francisco Jose de , Moraes Junior Frederico Bento de , Lopes Maria de Fátima Aguiar , Tozo Tatiana Aparecida Affornali , Purim Kátia Sheylla Malta , Mota Jorge , Leite Neiva 
Published: August 2023

AbstractThe aims of the study were to examine the moderating role of physical activity in
the relationship between cardiometabolic risk factors and adiponectin
concentration in adolescents. This is a cross-sectional study conducted with 96
adolescents of both sexes, between 11 and 17 years old. Body mass, height, fat
mass (FM), fat-free mass, systolic blood pressure, diastolic blood pressure,
high density lipoprotein, low density lipoprotein (LDL-c), triglycerides,
insulin, adiponectin, C-reactive protein, and level of physical activity (energy
expenditure questionnaire) were measured. Body mass index (BMI), triponderal
mass index (TMI), homeostasis model to assessment insulin resistance (HOMA-IR),
and quantitative insulin sensitivity check index (QUICKI) were calculated.
Macro-PROCESS for SPSS was used for moderation analyses. Direct interactions
were found for BMI, TMI, FM, insulin, and HOMA-IR and inverse for LDL-c, and
QUICKI. Protection against cardiometabolic risk was found when the PA-coeff was
completed above 1.57 coeff (BMI), 1.62 coeff (TMI), 1.55 coeff (FM), 1.41 coeff
(LDL-c)1.60 coeff (insulin), 1.59 coeff (HOMA-IR) and 1.35 coeff (QUICKI). We
conclude that physical activity was a moderator in the relationship with
adiposity, insulin resistance and sensitivity, LDL-c, and adiponectin. In this
context, we evidenced a relevant clinical impact on the health of adolescents,
demonstrating the interaction between anthropometrics variables and physical
activity.
Current Research on Vitamin D Supplementation against Sarcopenia: A
Review of Clinical Trials
Authors: Kressel Heidi , Matsakas Antonios 
Published: August 2023

AbstractVitamin D plays an important role in skeletal muscle function and metabolism. The
aim of this review was A) to discuss the clinical evidence of vitamin D
supplementation either alone or combined with other strategies in the prevention
of sarcopenia in non-sarcopenic individuals and B) to critically discuss the
clinical evidence on the effect of vitamin D combined with other strategies on
muscle strength, mass and function in sarcopenic individuals without vitamin D
deficiency. Sparse clinical data on non-sarcopenic individuals indicate that
vitamin D alone has a subtle beneficial effect on knee extensor strength at
doses 880–1600 IU/day without improving handgrip strength or
muscle mass. When co-administered with other supplements such as protein, mixed
effects appear to prevent the decline of muscle mass, possibly delaying the
onset of sarcopenia in non-sarcopenic individuals, at doses of 800–1,000
IU/day over 6–12 weeks. In sarcopenic individuals, vitamin D
100–1,000 IU/day co-supplementation with protein results in
increased handgrip strength between 9.8–40.5%. However, there is
no strong clinical evidence that vitamin D dosage correlates with changes in
muscle strength or mass. Potential sources of discrepancy among studies are
discussed. Future studies with appropriate experimental design are essential to
dissect the net effect of vitamin D on sarcopenia.
Thyroid-Related Hormones Changes Predict Changes in Anthropometric
Measures and Incidence of Obesity in Chinese Euthyroid Persons
Authors: Deng Ling , Zheng Xiaoxia , Shuai Ping , Yu Xijie 
Published: August 2023

AbstractThe purpose of this study was to investigate the correlation of thyroid-related
hormones changes within the reference range with the changes in anthropometric
measures and incidence of obesity. The study included 4850 subjects with normal
thyroid-related hormones at baseline and at follow-up. We evaluated the
relationship of changes in thyroid-related biomarkers with anthropometric
measures changes and incidence of obesity. In euthyroid persons, changes in
serum thyroid stimulating hormone (TSH), free triiodothyronine (FT3), and free
thyroxine (FT4) concentrations and FT3/FT4 ratio were independent
predictors of changes in body mass index (BMI) and waist circumference (WC) in
men, changes in serum FT3 and FT4 concentrations and FT3/FT4 ratio were
independent predictors of changes in BMI and WC in women. Every single unit
increment in ΔFT3/FT4 was accompanied by a 7.144 and 7.572 times
risk of having obesity in men and women, respectively. Every single unit
decrement in ΔFT4 was accompanied by a 21.0% and 26.9%
lower risk of having obesity in men and women, respectively. In conclusion, in
euthyroid individuals, changes in thyroid-related hormones were associated with
anthropometric measures changes and incidence of obesity.