bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mapping the global research landscape on malnutrition for patients with chronic kidney disease: a visualization analysis
Authors: Shakhshir Muna H. , Vanoh Divya , Hassan Mohanad , Zyoud Sa’ed H. 
Published: September 2023

AbstractBackgroundChronic kidney disease (CKD) is seen as a diverse disease and a primary contributor to global mortality. Malnutrition arises within chronic illness, which involves protein energy depletion and inadequate levels of essential nutrients. These factors increase the likelihood of death and the overall impact of the disease on affected individuals. Consequently, this study aims to utilize bibliometric and visual analysis to assess the current state of research, the latest advances and emerging patterns in the fields of CKD and malnutrition.MethodsExtensive research was conducted using the Scopus database, which is the most authoritative database of research publications and citations, to focus on CKD research between 2003 and 2022, as indicated by title and author keywords. Then, within this vast collection of academic publications, a notable subset of articles was exclusively dedicated to investigating the relationship between CKD and malnutrition. Finally, we performed bibliometric analysis and visualization using VOSviewer 1.6.19 and Microsoft Excel 2013.ResultsLarge global research between 2003 and 2022 resulted in 50,588 documents focused on CKD, as indicated by title and author keywords. In this extensive collection of scientific publications, a staggering portion of 823 articles is devoted exclusively to investigating the link between CKD and malnutrition. Further analysis reveals that this body of work consists of 565 articles (68.65%), 221 reviews (26.85%), and 37 miscellaneous entries (4.50%), which encompass letters and editorials. The USA was found to be the most productive country (n = 173; 21.02%), followed by Italy (n = 83; 10.09%), Sweden (n = 56; 6.80%), Brazil (n = 54; 6.56%) and China (n = 51; 6.20%). The most common terms on the map include those related to the topic of (a) malnutrition in hemodialysis patients and predicting factors; terms associated with the (b) impact of malnutrition on cardiovascular risk and complications in CKD patients; and terms related to the (c) dietary protein intake and malnutrition in CKD.ConclusionsThis study is the first of its kind to analyze CKD and malnutrition research using data from Scopus for visualization and network mapping. Recent trends indicate an increasing focus on protein-energy wasting/malnutrition in hemodialysis patients and predicting factors, dietary protein intake, and malnutrition in CKD. These topics have gained significant attention and reflect the latest scientific advances. Intervention studies are crucial to examining diet therapy's impact on patients with stages 1 to 5 CKD. We hope this study will offer researchers, dietitians and nephrologists valuable information.
Dynamic contrast-enhanced ultrasonography with sonazoid predicts microvascular invasion in early-stage hepatocellular carcinoma
Authors: Huang Zhe , Xin Jun-Yi , Wu Ling-Ling , Luo Hong-Chang , Li Kaiyan 
Published: September 2023

Objective Microvascular invasion (MVI) is an independent risk factor for the early recurrence and poor survival of hepatocellular carcinoma (HCC). This study aims to investigate the potential clinical value of dynamic contrast-enhanced ultrasound (DCE-ultrasound)-Sonazoid in pre-operatively assessing MVI in HCC. Methods and materials This single centre prospective study included 140 patients with histopathologically confirmed single HCC lesions. Patients were classified according to the post-operative pathological information presence of MVI: MVI+ group (n = 32) and MVI– group (n = 108). All patients underwent DCE-ultrasound within 1 week before surgery. The quantitative perfusion parameters of HCC lesions, margins of HCC lesions, and distal liver parenchyma were obtained and analyzed. Results Clinicopathological (serum alpha-fetoprotein, Des-gamma-carboxyprothrombin, and pathological grade) and grayscale imaging features (tumor size) were significantly different between the MVI+ and MVI– groups (p < 0.05). Further quantitative analysis showed that when comparing the MVI+ and MVI– groups, half-decrease time and wash-out rate of HCC lesions and peak enhancement in the arterial phase of difference between the margin area of HCC and distal liver parenchyma were significantly different (p = 0.045, p = 0.035, and p = 0.023, respectively). Combining the above three quantitative parameters, the accuracy, sensitivity, specificity, positive-predictive value, and negative-predictive value were 69.3% (97/140), 37.8% (17/45), 84.3% (80/95), 53.1% (17/32), 74.1% (80/108), respectively. Conclusion: DCE-ultrasound with quantitative perfusion analysis has the potential to predict MVI in HCC lesions. Advances in knowledge DCE-ultrasound with quantitative perfusion analysis has the potential to predict MVI in HCC lesions.
Detecting residual soft tissue sarcoma after unplanned excision; model-free analysis of dynamic contrast-enhanced MRI at short-term follow-up
Authors: Ahn Hyemin , Lee Min Hee , Byun Seung Hee , Kim Hwa Jung , Kim Wanlim , Chee Choong Geun , Chung Hye Won , Yoon Min A , Lee Sang Hoon 
Published: September 2023

Objectives
To evaluate diagnostic utility of additional DCE-MRI for detecting residual soft tissue sarcomas (STS) after unplanned excision (UPE).

Methods
We retrospectively evaluated 32 patients with UPE of STS, followed by conventional MRI with DCE-MRI and wide excision (WE), between November 2019 and January 2022. Residual tumors on conventional MRI were categorized into three groups: Lesion-type-0, no abnormal enhancement, Lesion-type-1, an indeterminate lesion, and Lesion-type-2, a definite enhancing nodule. On DCE-MRI, ROIs were manually placed on enhancing areas of suspected residual tumor. The mean and 95th percentile values of AUC of time-intensity curve were calculated at 60, 90, and 120 s of Enhancement-cycle-1 and -2. Optimal DCE parameters were identified by ROC analysis. Diagnostic performance of conventional MRI and DCE-MRI was compared using McNemar’s test.

Results
On WE, residual tumor was present in 23 (71.9%) of 32 patients. On MRI, Lesion-type-1 was found in 16/32 (50%) patients and Lesion-type-2 in 16/32 (50%). The optimal DCE parameter was the 95th percentile value of AUC at 120s of Enhancement-cycle-2. The sensitivity, specificity, and AUC were as follows: 65.2% (95% CI, 45.8–85.7%), 88.9% (CI, 68.4–100%), and 0.77 (CI, 0.62–0.92) for conventional MRI, and 100%, 55.6% (CI, 23.1–88.0%), and 0.78 (CI, 0.61–0.95) for combined conventional and DCE-MRI.

Conclusions
Additional DCE-MRI aided in detecting residual STS after UPE, particularly in cases without definite soft tissue nodular enhancement.

Advances in knowledge
Close follow up may be suggested for patients showing abnormality in DCE-MRI, with more suspicion of residual tumor.
The utility of [18F]Fluciclovine PET/CT in Evaluating Nonmetastatic Castrate-Resistant Prostate Cancer Patients (nmCRPCp): diagnostic performance and impact on management
Authors: Soliman Moataz , Elfatairy Kareem , Ellessy Reham , Velichko Yury S , Avery Ryan , kelahan Linda C , Ross Ashley E , Savas Hatice 
Published: September 2023

Objective:
To evaluate the role of [18F]Fluciclovine PET/CT scan in restaging nmCRPCp and its impact on management.

Methods and materials:
This retrospective study included all patients with nonmetastatic castrate-resistant prostate cancer, who underwent [18F]Fluciclovine PET/CT scans for restaging who had concern for disease progression. Two radiologists independently reviewed the PET/CT studies, assigned an overall impression, and reported the site and number of radiotracer activities in consensus and impact on management was recorded. Available tissue diagnosis and/or six-month clinical and imaging follow-up were used as reference standards.

Results:
Thirty-five patients were included in this study. At least one lesion was detected in 73% (26/35) of the scans. Management changed in 71% (25/35) of patients, (22 positives and three negative scans). 26.9% (7/26) of patients were found to have an oligometastatic disease. Based on the reference standards, the diagnostic performance of [18F]Fluciclovine PET/CT in detecting recurrence in nmCRCP has 86%, sensitivity, 83% specificity, 96.1% PPV, and 55.5% NPV. There was no relationship between the Gleason score and a positive PET/CT scan in our patient population.

Conclusion:
Detecting the source of recurrence is challenging in nmCRCP patients when conventional imaging fails. Given the high PPV, sensitivity, and specificity, [18F]Fluciclovine PET/CT can be used instead of conventional imaging as a first-line choice due to its superiority over bone scan and added value of detecting soft tissue metastasis regardless of the initial Gleason score.

Advances in knowledge:
The study highlights the added value of [18F]Fluciclovine PET/CT in detecting soft tissue metastasis regardless of the initial Gleason score, which is not possible with conventional imaging such as bone scans.
The study highlights the potential role of [18F]Fluciclovine PET/CT guiding management change for nonmetastatic castrate-resistant prostate cancer patients, particularly those with oligometastatic disease.
Building on the Health Policy Analysis Triangle: Elucidation of the Elements
Authors: Zahidie Aysha , Iqbal Meesha , Asif Saima 
Published: September 2023

The health policy triangle first presented in the 20th century by Walt and Gilson has been extensively used at local, national, regional, and international levels to assess health policies related to communicable and non-communicable diseases, physical and mental health, antenatal and postnatal care, and human resources, services, and systems. However, the framework lacks intricate details for the four pillars in the triangle viz: ‘content,’ ‘context’, ‘actors’, and ‘processes. We propose a checklist of elements to be considered for each pillar; to ease and enhance the process of policy analyses for researchers and policymakers across the globe, including low- and middle-income countries. We suggest using Leichter’s categorization of situational, structural, cultural, and environmental factors for comprehensive contextual assessment. Kingdon’s multiple streams framework can be applied to determine the ‘window of opportunity’ allowing the politics, policy, and problem streams to unite, giving birth to the formulation of policies. Lastly, stakeholders’ analyses expounding the power, influence, interest, and involvement of intrinsic, extrinsic, implicit, and explicit players should be applied to explore the ‘actors’ in policy analyses. Robust policy analyses for generating evidence are of paramount importance for policymakers for informed decision-making. Our approach of dis-entangling and elaborating the pillars of the triangle will be helpful for health systems researchers at sub-national, national, regional and global levels to serve as a basis for evidence-based informed decision-making.
doi: https://doi.org/10.12669/pjms.39.6.7056
How to cite this: Zahidie A, Asif S, Iqbal M. Building on the Health Policy Analysis Triangle: Elucidation of the Elements. Pak J Med Sci. 2023;39(6):1865-1868 doi: https://doi.org/10.12669/pjms.39.6.7056
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Diagnostic Accuracy of 18F-FDG PET - CT Imaging in determining the bone marrow involvement (BMI) in pediatric Hodgkin’s Lymphoma (HL)
Authors: Naveed Sana , Faheem Hira , Shazlee Kashif , Ashraf Muhammad Shamvil 
Published: September 2023

Objective: To determine diagnostic accuracy of 18F-FDG PET - CT imaging in determining Bone marrow involvement in pediatric HL by taking bone marrow biopsy as standard.
Method: This descriptive cross-sectional study was conducted in the Department of Pediatric Hematology/Oncology, Indus Hospital and Health Network, Karachi from July 2021 to December 2022. Treatment naïve histologically proven pediatric HL patients of both gender and aged between two to 16 years with both 18F-FDG PET - CT and bone marrow biopsy imaging were included. Basic demographics such as age, gender, height, weight, as well as classification and staging of HL was obtained. Results were assessed by expert reviewers who were blinded to clinical outcome. Sensitivity, specificity, positive and negative predictive value, and diagnostic precision were assessed. The data was analyzed via SPSS 26.0.
Results: Total 131 participants were included with a male predominance i.e. 104 (79.6%). The mean (±SD) age was 8.7 ± 3.4 years. The present study reported PET/CT to have a sensitivity, specificity diagnostic accuracy, PPV and NPV of 94.1%, 92%, 92%, 64% and 99% respectively.
Conclusion: Our findings support the idea that BMB should not be routinely conducted in all patients but rather can be reserved exclusively for patients with dubious 18F-FDG bone marrow findings, as this test has strong diagnostic potential for evaluating BMI involvement in HL.
doi: https://doi.org/10.12669/pjms.39.6.7721
How to cite this: Naveed S, Faheem H, Shazlee K, Ashraf MS. Diagnostic Accuracy of 18F-FDG PET - CT Imaging in determining the bone marrow involvement (BMI) in pediatric Hodgkin’s Lymphoma (HL). Pak J Med Sci. 2023;39(6):1830-1834. doi: https://doi.org/10.12669/pjms.39.6.7721
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Generalized Synthetic Control for TestOps at ABI: Models, Algorithms, and Infrastructure
Authors: Costa Luis , Farias Vivek F. , Foncea Patricio , Gan Jingyuan (Donna) , Garg Ayush , Montenegro Ivo Rosa , Pathak Kumarjit , Peng Tianyi , Popovic Dusan 
Published: September 2023

We describe a novel optimization-based approach—generalized synthetic control (GSC)—in which we learn from experiments conducted in a physical retail environment. GSC solves a long-standing problem of learning from experiments conducted in this environment when treatment effects are small, the environment is extremely noisy and nonstationary, and interference and adherence problems are commonplace. The utilization of GSC has demonstrated a remarkable increase in statistical power, approximately one hundredfold (100×) higher than conventional inferential methods. This innovative approach forms the basis of TestOps, a pioneering large-scale experimentation platform designed specifically for physical retailers. TestOps was developed and has been broadly implemented as part of a collaboration between Anheuser Busch Inbev (ABI) and a team of operations researchers and data engineers from the Massachusetts Institute of Technology. TestOps currently runs physical experiments impacting approximately 135 million USD in revenue every month and routinely identifies innovations that result in a 1%–2% increase in sales volume. The vast majority of these innovations would have remained unidentified had we not developed our novel approach to inference. Prior to our implementation, statistically significant conclusions could be drawn on only ∼6% of all experiments, a fraction that has now increased by 10-fold. Given its success, TestOps is being rolled out globally at ABI, driving significant revenue growth and enabling the extraction of valuable insights from large-scale physical experiments. History: This paper has been accepted for the INFORMS Journal on Applied Analytics Special Issue—2022 Daniel H. Wagner Prize for Excellence in the Practice of Advanced Analytics and Operations Research.
Opioids for acute and chronic pain when receiving psychiatric medications
Authors: Janakiram Chandrashekar , Okunev Ilya , Tranby Eric P. , Fontelo Paul , Iafolla Timothy J. , Dye Bruce A. 
Published: September 2023

Background
People with mental health disorders (MHD) like depression and anxiety are more likely to experience substance use disorders (SUDs) than those without MHD. This study assesses opioid prescription patterns for acute or chronic pain management in patients receiving medication for depression and/or anxiety.

Methods and findings
Cross-sectional data trend analysis of 24.5 million adult medical claims was conducted using medical and pharmacy data (2012–2019) for adults aged 21–64 from the IBM Watson MarketScan Medicaid Multi-State Database. Information on sex, age, race, provider type, acute or chronic pain, and prescriptions for opioids and antidepressant and/or antianxiety medication from outpatient encounters were analyzed. For those receiving opioid prescriptions within 14 days of a pain diagnosis, ICD-10-CM codes were used to categorize diagnoses as chronic pain (back pain, neck pain, joint pain, and headache); or acute pain (dental-, ENT-, and orthopedic-related pain). Nearly 8 million adults had at least one prescription for antidepressant or antianxiety medications (MHD), with 2.5 million of those (32%) also diagnosed with an acute or chronic pain condition (pain + MHD). Among the pain + MHD group, 34% (0.85 million) received an opioid prescription within 14 days of diagnosis. Individuals with chronic pain diagnoses received a higher proportion of opioid prescriptions than those with acute pain. Among individuals with pain + MHD, the majority were aged 50–64 (35%), female (72%), and non-Hispanic white (65.1%). Nearly half (48.2%) of the opioid prescriptions given to adults with an MHD were provided by physicians. Compared to other physician types, Health Care Providers (HCPs) in emergency departments were 50% more likely to prescribe an opioid for dental pain to those with an MHD, whereas dentists were only half as likely to prescribe an opioid for dental pain management. Although overall opioid prescriptions for pain management declined from 2012 to 2019, adults with an MHD received opioids for pain management at nearly twice the level as adults without an MHD.

Conclusions
Although HCPs have reduced opioids for acute or chronic pain to patients at high-risk for SUD, for example, those with MHD, the use of opioids for pain management has remained at consistently higher levels for this SUD high-risk group, suggesting the need to revisit pain management guidelines for those receiving antidepressant or antianxiety drugs.
Rare Case of Pediatric Post-transplant Lymphoproliferative Disorder Presenting With Pleural Masses Complicated by Pleural Effusions
Authors: Nessim Kostandy Erini , Wan David , Imseis Essam 
Published: September 2023

ABSTRACT
Post-transplant lymphoproliferative disorder is a complication in organ transplant recipients characterized by uncontrolled proliferation of B-lymphocytes, occurring in 6% of pediatric patients, with risk factors including primary Epstein-Barr virus infection, intensity of immunosuppression, and cytomegalovirus infection. The clinical symptoms are often nonspecific, and it is associated with a high mortality rate if left untreated. We describe a rare case of post-transplant lymphoproliferative disorder who presented with pleural-based masses resulting in pleural effusions.
Influence of the selection of different construction materials on the stress–strain state of the track
Authors: Yin ZhiWei 
Published: September 2023

Abstract
The properties of epoxy asphalt materials and carbon fiber composites are closely related to temperature, so it is important to study the mechanical properties of these two materials when they are used in track at different temperatures. The parallel analysis method is adopted in this study. The carbon fiber composite is regarded as a continuous elastomer, and its stress and strain components are fully expressed in a matrix form in a three-dimensional coordinate system. Finally, 21 elastic constants are selected. At the same time, the mechanical properties of epoxy asphalt materials in viscoelastic and tensile aspects were studied considering the temperature zone expansion factor. The results show that the maximum degradation of carbon fiber composites in tensile strength occurs at low temperature and dry state, and the degradation rate is 30.8%. In terms of compressive strength, the maximum degradation rate of the material is 21.9% under high temperature and wet conditions. The elongation at break of epoxy asphalt materials showed a trend of first increasing and then decreasing. In the whole working temperature zone, it increased from 311.78 to 354.55% and then decreased to 228.89%. The bond elongation first increases and then decreases. Taking 0℃ as the dividing point, the bond elongation increases from 85.7% at − 20℃ to 256.7% at 0℃ in the temperature zone below 0℃, while it decreases from 256.7% at 0℃ to 80.6% in the temperature zone above 0℃. Therefore, the mechanical properties of the two materials have the characteristics of high temperature sensitivity.
Relationship between physical, mechanical and thermal properties of flexible chain polymers
Authors: Kolupaev B.B. , Kolupaev B.S. , Levchuk V.V. 
Published: September 2023

The results of the study on the relationship between the physical, mechanical and thermal properties of linear flexible polymers due to the harmonic and anharmonic components of the interatomic and intermolecular interaction force are presented. Using the example of polyvinyl chloride (PVC), polyvinyl butyral (PVB), polystyrene (PS), it is shown that in the region of 300 K < = T < = 400 K, the relaxation state of the system is realized due to the mobility of the structural elements, which makes it possible to apply the terms of thermodynamics and statistics of small systems to the properties of the material, and to treat the polymeric state as a special form of condensation of matter. The quantitative relationship between the properties of systems has been established, which is of interest for creating scientific foundations for predicting, obtaining and operating materials under the action of external fields of various nature.
Migraciones intra-urbanas postpandemia en el partido de La Plata
Authors: Jensen Karina , Arias Florencia Belén , Nader María Paz 
Published: September 2023

La pandemia por el COVID-19 y las restricciones aplicadas al uso del espacio público en el partido de La Plata, por el aislamiento social, preventivo y obligatorio (ASPO) durante el período 2020-2021, han dado lugar a modificaciones en las dinámicas socioterritoriales, con repercusiones directas en el entorno urbano. Estas se ven reflejadas en el creciente proceso migratorio interno de determinados sectores de la población desde el casco urbano hacia la periferia. La investigación parte de una encuesta utilizada como instrumento de recolección de datos en relación con las necesidades y deficiencias habitacionales en el partido en el periodo 2020-2021. Concluido el período de aislamiento, se realizó la fase II de la encuesta en la periferia para identificar las migraciones internas y el proceso de conformación de las nuevas áreas urbanizadas en el periodo 2021-2022, con el objetivo de poner de manifiesto las migraciones intra-urbanas postpandemia. En este sentido, los resultados evidencian la expansión que se dio en la periferia y cómo fue su crecimiento; esta situación es muy dispar en las distintas periferias y en el centro, debido a las posibilidades que poseen los diferentes habitantes.