bluuebunny/crossref_metadata_2025_split huggingface dataset:
MEMO1 is a Metal Containing Regulator of Iron Homeostasis in Cancer Cells
Authors: Dolgova Natalia , Uhlemann Eva-Maria E. , Boniecki Michal T. , Vizeacoumar Frederick S. , Ralle Martina , Tonelli Marco , Abbas Syed A. , Patry Jaala , Elhasasna Hussain , Freywald Andrew , Vizeacoumar Franco J. , Dmitriev Oleg Y. 
Published: March 2023

AbstractMediator of ERBB2-driven Cell Motility 1 (MEMO1) is an evolutionary conserved protein implicated in many biological processes; however, its primary molecular function remains unknown. Importantly, MEMO1 is overexpressed in many types of cancer and was shown to modulate breast cancer metastasis through altered cell motility.To better understand the function of MEMO1 in cancer cells, we analyzed genetic interactions of MEMO1 using gene essentiality data from 1028 cancer cell lines and found multiple iron-related genes exhibiting genetic relationships with MEMO1. We experimentally confirmed several interactions between MEMO1 and iron-related proteins in living cells orin vitro, most notably, the iron transporters transferrin (TF), transferrin receptor 2 (TFR2), and mitoferrin-2 (SLC25A28), and the global iron response regulator IRP1 (ACO1). These interactions indicate that cells with high MEMO1 expression levels are hypersensitive to the disruptions in iron distribution. Our data also indicate that MEMO1 is involved in ferroptosis and is linked to iron supply to mitochondria.We have found that purified MEMO1 binds iron with high affinity under redox conditions mimicking intracellular environment and solved MEMO1 structures in complex with iron and copper. Our work reveals that the iron coordination mode in MEMO1 is very similar to that of iron-containing extradiol dioxygenases, which also display a similar structural fold. We conclude that MEMO1 is an iron-binding protein that regulates iron homeostasis in cancer cells.
UBE3A and transsynaptic complex NRXN1-CBLN1-GluD1 in a hypothalamic VMHvl-arcuate feedback circuit regulates aggression
Authors: Nong Yi , Stoppel David C. , Johnson Mark A. , Boillot Morgane , Todorovic Jelena , Shen Jason , Zhou Xinyu , Nadler Monica J.S. , Rodriguez Carrie , Huo Yuda , Nagakura Ikue , Kasper Ekkehard M. , Anderson Matthew P. 
Published: March 2023

AbstractThe circuit origins of aggression in autism spectrum disorder remain undefined. Here we reportTac1-expressing glutamatergic neurons in ventrolateral division of ventromedial hypothalamus (VMHvl) drive intermale aggression. Aggression is increased due to increases ofUbe3agene dosage in the VMHvl neurons when modeling autism due to maternal 15q11-13 triplication. Targeted deletion of increasedUbe3acopies in VMHvl reverses the elevated aggression adult mice. VMHvl neurons form excitatory synapses onto hypothalamic arcuate nucleus AgRP/NPY neurons through a NRXN1-CBLN1-GluD1 transsynaptic complex and UBE3A impairs this synapse by decreasingCbln1gene expression. Exciting AgRP/NPY arcuate neurons leads to feedback inhibition of VMHvl neurons and inhibits aggression. Asymptomatic increases of UBE3A synergize with a heterozygous deficiency of presynapticNrxn1or postsynapticGrid1(both ASD genes) to increase aggression. Targeted deletions ofGrid1in arcuate AgRP neurons impairs the VMHvl to AgRP/NPY neuron excitatory synapses while increasing aggression. Chemogenetic/optogenetic activation of arcuate AgRP/NPY neurons inhibits VMHvl neurons and represses aggression. These data reveal that multiple autism genes converge to regulate the VMHvl-arcuate AgRP/NPY glutamatergic synapse. The hypothalamic circuitry implicated by these data suggest impaired excitation of AgRP/NPY feedback inhibitory neurons may explain the increased aggression behavior found in genetic forms of autism.One Sentence SummaryA feedback circuit in the hypothalamus that inhibits aggression is impaired by converging autism genetic defects.
The evolution of skilled hindlimb movements in birds: A citizen science approach
Authors: Gutiérrez-Ibáñez Cristián , Amaral-Peçanha Clara , Iwaniuk Andrew N. , Wylie Douglas R. , Baron Jerome 
Published: March 2023

AbstractThe ability to manipulate objects with limbs has evolved repeatedly among land tetrapods. Several selective forces have been proposed to explain the emergence of forelimb manipulation, however, work has been largely restricted to mammals, which prevents the testing of evolutionary hypotheses in a comprehensive evolutionary framework. In birds, forelimbs have gained the exclusive function of flight, with grasping transferred predominantly to the beak. In some birds, the feet are also used in manipulative tasks and appear to share some features with manual grasping and prehension in mammals, but this has not been systematically investigated. Here we use large online repositories of photographs and videos to quantify foot manipulative skills across a large sample of bird species (>1000 species). Our results show that a complex interaction between niche, diet and phylogeny drive the evolution of manipulative skill with the feet in birds. Furthermore, we provide strong support for the proposition that an arboreal niche is a key element in the evolution of manipulation in land vertebrates. Our systematic comparison of foot use in birds provides a solid base for understanding morphological and neural adaptations for foot use in birds, and for studying the convergent evolution of manipulative skills in birds and mammals.
The dynamics in asymmetric effects of multi-attributes on customer satisfaction: evidence from COVID-19
Authors: Kim Jong Min , Liu Jiahao , Park Keeyeon Ki-cheon 
Published: March 2023

Purpose
This study aims to explore how the “new normal” induces the dynamics in the asymmetric relationship between service quality attributes and customer satisfaction.

Design/methodology/approach
This study analyzes online reviews for hotels in New York City. The authors use multi-attribute models to examine how a situational factor – the COVID-19 outbreak – creates dynamics in the asymmetric effect of service quality attributes on customer satisfaction. Then, the authors examine the change in these dynamics over time after adjusting to the “new normal.”

Findings
The COVID-19 pandemic has introduced dynamics into the asymmetrical relationship between hotel service attribute performances and customer satisfaction. The pandemic magnified the asymmetric influences of particular attributes on satisfaction in the hospitality industry. In addition, the findings indicate the changes in such dynamics over time.

Practical implications
The findings emphasize that hotel managers should consider situational factors when understanding customer satisfaction. Particularly, this study suggests developing tailored strategies for responses during the COVID-19 pandemic. Hotel managers need to address changing customer expectations of service attributes to overcome unprecedented difficulties because of the limitations and new needs imposed during the pandemic.

Originality/value
This study contributes to the hospitality literature with an understanding of the significance of situational factors in asymmetric analysis.
Realizing potential through absorptive capacity to create competitive advantage in hospitality organizations
Authors: Lim SangGon (Edward) , Ok Chihyung “Michael” 
Published: March 2023

Purpose
Absorptive capacity is a knowledge-processing ability that hospitality organizations should hone to create competitive advantage in a fierce business environment. This study aims to examine an integrative model explaining how hospitality organizations infuse external knowledge into competitive advantage via absorptive capacity processes and opportunity-capturing abilities.

Design/methodology/approach
This study used structural equation modeling, using the R Lavaan package, with 288 survey responses collected from hospitality employees.

Findings
Structural equation modeling with multiple indirect relationships presents a holistic picture of how hospitality organizations develop externally acquired knowledge into organizational outcomes through detailed absorptive capacity processes. Unit size is found to positively moderate the indirect relationship between external acquisition and competitive advantage through knowledge transformation only. Competitiveness level negatively moderates indirect relationships through assimilation and transformation.

Practical implications
The findings highlight the importance of hospitality organizations’ knowledge management capabilities through acquisition, assimilation, transformation and exploitation processes. These integrative mechanisms can be facilitated by intraorganizational coordinative processes through collective interpretations and applications of knowledge and effective organizational routines based on management and technical support.

Originality/value
This study proposes an integrative model encompassing a process perspective and the role of intraorganizational coordination in bridging potential and realized absorptive capacity.
Lean innovation training and transformational leadership for employee creative role identity and innovative work behavior in a public service organization
Authors: Tan Amy B.C. , van Dun Desirée H. , Wilderom Celeste P.M. 
Published: March 2023

Purpose
With the growing need for employees to be innovative, public-sector organizations are investing in employee training. This study aims to examine the effects of a combined Lean Six Sigma and innovation training, using action learning, on public-sector employees’ creative role identity and innovative work behavior.

Design/methodology/approach
The authors studied a public service agency in Singapore in which a five-day Lean Innovation Training was implemented, using a combination of Lean Six Sigma and Creative Problem-Solving tools, with a simulation on day one and subsequent team-based project coaching, spread over six months. The authors administered pre- and postintervention surveys among all the employees, and initiated group interviews and observations before, during and after the intervention.

Findings
Creative role identity and innovative work behavior had significantly improved six months after the intervention, enabled through senior management’s transformational leadership. The training induced managers to role-model innovative work behaviors while cocreating, with their employees, a renewal of their agency’s core processes. The three completed improvement projects contributed to an innovative work culture and reduced service turnaround time.

Originality/value
Starting with a role-playing simulation on the first day, during which leaders and followers swapped roles, the action-learning type training taught all the organizational members to use various Lean Six Sigma and Creative Problem-Solving tools. This nimble Lean Innovation Training, and subsequent team-based project coaching, exemplifies how advancing the staff’s creative role identity can have a positive impact.
Usage behavior of mHealth service users in Australia: do user demographics matter?
Authors: Talukder Majharul , Aroos-Sheriffdeen Seyed , Khan Md Irfanuzzaman , Quazi Ali , Abdullah ABM 
Published: March 2023

Purpose
Mobile health (mHealth) service is an Australian Government initiative aiming to improve the quality of health-care services. However, little is known about Australian health consumers’ willingness to adopt mHealth. The purpose of this paper is to study the usage behavior of mHealth service users in Australia. While various factors may impact users’ willingness to accept mHealth, this research investigates factors influencing the mHealth adoption decisions of the Australian health-care consumers, and the moderating impact of demographic factors on the usage behavior (UB) of mHealth services which has been rarely addressed in an Australian setting in the past.

Design/methodology/approach
The theoretical framework is based on the technology acceptance model (TAM). Data were collected from residents of the Australian Capital Territory using a survey questionnaire and examined using partial least squares structural equation modeling.

Findings
The proposed mHealth usage model demonstrated a good fit and indicated that perceived usefulness, perceived ease of use, social influence, service quality and government influence are critical issues shaping mHealth UB. The moderation analysis revealed that users’ demographics, namely, gender, age and education are instrumental in broadening the understanding of UB of mHealth service in Australia.

Practical implications
The findings will inform health-care service providers about the critical importance of the key factors driving the usage of mHealth services. Health-care providers and relevant authorities can develop targeted communication strategies that maximize the acceptance of mHealth services. Furthermore, deeper understanding of users’ demographic profiles would enable health-care service providers to promote their services to the right clients.

Originality/value
The above findings on the factors and user demographics informing the usage of mHealth services have unique practical, contextual and theoretical implications.
Need satisfaction and frustration scale (NSFS): adaptation and validation for Brazilian gig work context
Authors: Nunes Paula Martins , Carozzo-Todaro Mauro Enrique , Proenca Teresa 
Published: March 2023

Purpose
This study aims to adapt and validate the need satisfaction and frustration scale (NSFS) for the Brazilian gig work context and investigate the distinctiveness of the constructs of basic needs satisfaction and frustration among Brazilian gig workers.

Design/methodology/approach
Exploratory factor analysis (EFA) and confirmatory factor analysis (CFA) were conducted on a sample of 351 Brazilian gig workers.

Findings
Results from EFA supported a three-factor structure, while results from CFA psychometrically supported a six-factor correlated model. The items that constitute the NSFS presented good discriminant validity (heterotrait-monotrait ratio) and internal consistency (Cronbach’s alpha and McDonald’s omega coefficients). Results regarding criterion validity partially support previous empirical evidence that considers needs satisfaction and frustration independent in relation to well-being and ill-being while reinforcing the need for further investigations. The Brazilian version of the NSFS is shown to be an instrument with robust psychometric qualities to assess workers’ perception of basic needs satisfaction and frustration in Brazilian gig work context.

Originality/value
This study broadens the scope of research on basic psychological needs by introducing a valid and reliable instrument to assess workers’ perceptions of needs satisfaction and frustration in the Brazilian gig work context, a population that has been neglected in self-determination theory research.
Shift work is not associated with dietary acid load in the NHANES
Authors: Storz Maximilian Andreas , Brommer Maria , Feraco Alessandra , Müller Alexander , Ronco Alvaro Luis , Lombardo Mauro 
Published: March 2023

Purpose
Changes in eating habits and food preferences caused by circadian rhythm disruptions in shift workers increase the risk for chronic diseases. Several studies demonstrated that shift work exerts adverse effects on various risk factors for cardiometabolic disease and cancer. Moreover, shift work leads to altered eating patterns, including diets low in alkaline foods (such as vegetables, fruit and legumes) and high in acidogenic foods (such as meat, fish and cheese). Previously not examined, this imbalance could result in a high dietary acid load (DAL). DAL has been linked to low-grade metabolic acidosis, tissue inflammation and other metabolic alterations. The aim of this study was to investigate the hypothesis that shift work is positively associated with an increased DAL.

Design/methodology/approach
The authors used cross-sectional data from the National Health and Nutrition Examination Surveys (2007–2010). The sample for this analysis was drawn from a representative multistage-probability sample of US civilians. DAL estimations included potential renal acid load (PRAL) and net endogenous acid production (NEAP). Acid load scores and nutrient intake were compared between regular day workers (n = 3,814; mean age, 43.7 ± 0.3; mean body mass index (BMI), 28.6 ± 0.1; females 46.9%) and shift workers (n = 881; age, 37.4 ± 0.6; BMI, 28.4 ± 0.3; females 48.1%). Evening/night shift workers combined with rotating shift workers were contrasted to participants on a regular daytime schedule.

Findings
Potassium and magnesium intake were significantly lower in shift workers, whereas no significant differences with regard to total energy intake were found. The authors found significantly higher crude NEAPF scores in shift workers (mean: 61.8 ± 1.2 mEq/day) compared to regular day workers (mean: 58.7 ± 0.5 mEq/day, P = 0.023). After adjustment for confounders, however, this association remained no longer significant. There were no significant intergroup differences regarding NEAPR and PRALR.

Research limitations/implications
This study revealed significant differences in crude NEAPF scores between shift workers and day workers. After adjustment for confounders, this association was no longer significant. Such discrepancy is probably because of the scarce homogeneity in the analyzed sample which represents the main limitation of this study. Thus, the results did not confirm the hypothesis that shift work is associated with elevated DAL scores. Importantly, the data suggest significant intergroup differences in nutrient intakes without confirming our initial hypothesis with regard to DAL.

Originality/value
In light of the detrimental health outcomes associated with an increased DAL, this study reinforces the call for evidence-based dietary guidelines in shift workers. Studies in other shift working populations are thus warranted.
Diffraction denoising using self‐supervised learning
Authors: Markovic Magdalena , Malehmir Reza , Malehmir Alireza 
Published: March 2023

AbstractDiffraction wavefield contains valuable information on subsurface composition through velocity extraction and sometimes anisotropy estimation. It can also be used for the delineation of geological features, such as faults, fractures and mineral deposits. Diffraction recognition is, therefore, crucial for improved interpretation of seismic data. To date, many workflows for diffraction denoising, including deep‐learning applications, have been provided, however, with a major focus on sedimentary settings or for ground‐penetrating radar data. In this study, we have developed a workflow for a self‐supervised learning technique, an autoencoder, for diffraction denoising on synthetic seismic, ground‐penetrating radar and hardrock seismic datasets. The autoencoder provides promising results especially for the ground‐penetrating radar data. Depending on the target of the studies, diffraction signals can be tackled using the autoencoder both as the signal and/or noise when, for example, a reflection is a target. The real hardrock seismic data required additional pre‐ and post‐autoencoder image processing steps to improve automatic delineation of the diffraction. Here, we also coupled the autoencoder with Hough transform and pixel edge detection filters. Along inlines and crosslines, diffraction signals have sometimes a similar character as the reflection and may spatially be correlated making the denoising workflow unsuccessful. Coupled with additional image processing steps, we successfully isolated diffraction that is generated from a known volcanogenic massive sulphide deposit. These encouraging results suggest that the self‐supervised learning techniques such as the autoencoder can be used also for seismic mineral exploration purposes and are worthy to be implemented as additional tools for data processing and target detections.
Application of chitosan nanoparticles in quality and preservation of postharvest fruits and vegetables: A review
Authors: Wang Su‐Yan , Herrera‐Balandrano Daniela D. , Jiang Yong‐Hui , Shi Xin‐Chi , Chen Xin , Liu Feng‐Quan , Laborda Pedro 
Published: March 2023

AbstractChitosan is an interesting alternative material for packaging development due to its biodegradability. However, its poor mechanical properties and low permeability limit its actual applications. Chitosan nanoparticles (CHNPs) have emerged as a suitable solution to overcome these intrinsic limitations. In this review, all studies regarding the use of CHNPs to extend the shelf life and improve the quality of postharvest products are covered. The characteristics of CHNPs and their combinations with essential oils and metals, along with their effects on postharvest products, are compared and discussed throughout the manuscript. CHNPs enhanced postharvest antioxidant capacity, extended shelf life, increased nutritional quality, and promoted tolerance to chilling stress. Additionally, the CHNPs reduced the incidence of postharvest phytopathogens. In most instances, smaller CHNPs (<150 nm) conferred higher benefits than larger ones (>150 nm). This was likely a result of the greater plant tissue penetrability and surface area of the smaller CHNPs. The CHNPs were either applied after preparing an emulsion or incorporated into a film, with the latter often exhibiting greater antioxidant and antimicrobial activities. CHNPs were used to encapsulate essential oils, which could be released over time and may enhance the antioxidant and antimicrobial properties of the CHNPs. Even though most applications were performed after harvest, preharvest application had longer lasting effects.
24 hours – Life in the E.R.: A state‐wide data linkage analysis of in‐patients with prolonged emergency department length of stay in New South Wales, Australia
Authors: Dinh Michael M , Bein Kendall J , Alkhouri Hatem , Ní Bhraonáin Sinéad , Seimon Radhika V 
Published: March 2023

AbstractObjectiveDescribe the characteristics and predictors of mortality for patients who spend more than 24 h in the ED waiting for an in‐patient bed and compare baseline clinical and demographic characteristics between tertiary and non‐tertiary hospitals.MethodsThis was a state‐wide analysis data linkage analysis of adult (age >16 years) ED presentations across New South Wales from 2019 to 2020. Cases were included if their mode of separation from ED indicated admission to an in‐patient unit including critical care ward and their ED length of stay was greater than or equal to 24 h. Cases were categorised by service‐related groups based on principle diagnosis.ResultsA total of 26 854 eligible cases were identified. The most common diagnosis groups were psychiatry, cardiology and respiratory. The odds ratio (OR) for 30‐day all‐cause mortality in admitted patients with an ED length of stay greater than 24 h were highest in those aged >75 years (OR 15.18, 95% confidence interval [CI] 9.99–23.07,P < 0.001), oncology (OR 10.45, 95% CI 7.93–13.77,P < 0.001) and haematology patients (OR 2.95, 95% CI 2.01–4.33,P < 0.001).ConclusionInterventions and models of care to address ED access block need to focus on mental health patients, older patients particularly those with cardiorespiratory illness and oncology and haematology patients for whom risk of mortality is disproportionately higher.