bluuebunny/crossref_metadata_2025_split huggingface dataset:
Targeting human γδ T cells as a potent and safe alternative to pan-T cells bispecific cell engagers
Authors: Boutin Lola , Barjon Clément , Lafrance Laura , Senechal Eric , Bourges Dorothée , Vigne Emmanuelle , Scotet Emmanuel 
Published: July 2023

AbstractOver the past decade, an increasing number of immunotherapies aiming to improve the ability of the immune system to effectively eradicate tumor cells have been developed. Among them, targeting effector T cell subsets of the immune system with bispecific antibodies, called T Cell Engagers (TCEs), represents an attractive strategy. TCEs are designed to specifically direct cytotoxic T cells towards tumor cells, thereby inducing a strong activation leading to the lysis of tumor cells. New strategies for targeting specific T-cell subsets are currently being explored. In this study, we investigated the activity of different TCEs on both conventional alpha beta (αβ) T cells and unconventional gamma delta (γδ) T cells. We generated TCE molecules based on camelid single-domain antibodies (VHHs) that target the tumor-associated antigen CEACAM5 (CEA), together with particular T-cell receptor chains (TCRs) or a CD3 domain. Thein vitrobiological activity of the TCEs against the colon carcinoma cell line LS174T was measured using fresh and cultured human Vγ9Vδ2 and αβ T cells. We showed that Vγ9Vδ2 T cells display stronger antitumor activityin vitrothan αβ T cells when activated with a CD3xCEA TCE. Furthermore, restricting T cell activation to Vγ9Vδ2 T cells limits the production of pro-tumor factors and pro-inflammatory cytokines, which are often associated with toxicity in patients. Taken together, these results suggest that Vγ9Vδ2γδ T cell-specific TCEs may represent safe, novel, specific, and effective molecules for improving antitumor immunotherapies.
Taxonomy supporting design strategies for reuse of building parts in timber-based construction
Authors: Lisco Margherita , Aulin Radhlinah 
Published: July 2023

Purpose
The reuse of timber building parts, when designing new buildings, has become a topic of increasing discussion as a proposed circular solution in support of sustainable development goals. Designers face the difficulty of identifying and applying different design strategies for reuse due to multiple definitions, which are used interchangeably. The purpose of this study is to propose a taxonomy to define the relationships between various concepts and practices that comprise the relevant strategies for reuse, notably design for disassembly (DfD) and design for adaptability (DfA).

Design/methodology/approach
Literature reviews were conducted based on research publications over the previous 12 years and located through the Web of Science and Scopus.

Findings
A taxonomy for the design process grounded on two strategies for reuse is presented: DfD and DfA. Based on previous work, the taxonomy aims to build a vocabulary of definitions in DfD and DfA to support other researchers and practitioners working in the field.

Research limitations/implications
The research is limited to the design phase of timber-based buildings. It does not take into account the other phases of the construction process, neither other kind of construction methods.

Practical implications
The application of the taxonomy can facilitate communication between different actors and provide a way for building product manufacturers to demonstrate their reuse credentials, enabling them to produce and promote compliant products and thereby support design for reuse strategies.

Social implications
This paper could contribute to a closer collaboration of all stakeholders involved in the building process since the very early phases of the conceptual design.

Originality/value
This paper contributes a comprehensive taxonomy to support the deployment of circular reuse strategies and assist designers and other stakeholders from the earliest of phases in the building’s life cycle. The proposed definition framework provided by the taxonomy resolves the longstanding lack of a supporting vocabulary for reuse and can be used as a reference for researchers and practitioners working with the DfD and DfA.
Cross-border alliances and strategic games
Authors: Tlemsani Issam , Matthews Robin , Mohamed Hashim Mohamed Ashmel 
Published: July 2023

PurposeThis empirical research examined the factors and conditions that contribute to the success of international strategic learning alliances. The study aimed to provide organisations with evidence-based insights and recommendations that can help them to create more effective and sustainable partnerships and to leverage collaborative learning to drive innovation and growth. The examination is performed using game theory as a mathematical framework to analyse the interaction of the decision-makers, where one alliance's decision is contingent on the decision made by others in the partnership. There are 20 possible games out of 120 outcomes that can be grouped into four different types; each type has been divided into several categories.Design/methodology/approachThe research methodology included secondary and primary data collection using empirical data, the Delphi technique for obtaining qualitative data, a research questionnaire for collecting quantitative data and computer simulation (1,000 cases, network resources and cooperative game theory). The key variables collected and measured when analysing a strategic alliance were identified, grouped and mapped into the developed model.FindingsMost respondents ranked reputation and mutual benefits in Type 1 games relatively high, averaging 4.1 and 3.85 of a possible 5. That is significantly higher than net transfer benefits, ranked at 0.61. The a priori model demonstrate that Type 1 games are the most used in cooperative games and in-game distribution, 40% of all four types of games. This is also confirmed by the random landscape model, approximately 50%. The results of the empirical data in a combination of payoff characteristics for Type 1 games show that joint and reputation benefits are critical for the success of cooperation.Practical implicationsResearch on cross-border learning alliances has several implications. Managerial implications can help managers to understand the challenges and benefits of engaging in these activities. They can use this knowledge to develop strategies to improve the effectiveness of their cross-border learning alliances. Practical implications, the development of game theory and cross-border models can be applied in effective decision-making in a variety of complex contexts. Learning alliances have important policy implications, particularly in trade, investment and innovation. Policymakers must consider the potential benefits and risks of these collaborations and develop policies that encourage and support them while mitigating potential negative impacts.Originality/valueInternational learning alliances have become a popular strategy for firms seeking to gain access to new knowledge, capabilities and markets in foreign countries. The originality of this research lies in its ability to contribute to the understanding of the dynamics and outcomes of these complex relationships in a novel and meaningful way.
Blister test to evaluate the multiwall carbon nanotubes (MWCNT) - Woven carbon fiber-reinforced epoxy used for repairing pipelines
Authors: Ahmed Payman Sahbah , Kamal Ava Ali , Abdulkader Niveen Jamal , Fadhil Basim Mohammed , Khoshnaw Fuad 
Published: July 2023

PurposePipelines are subject to pits, holes and cracks after staying in service for a while, especially in harsh environments. To repair the pipelines, composite materials are used, due to composite materials' low cost, high-corrosion resistance and easy handling. This study aims to investigate the reliability of the blister test for evaluating the bonding strength of multiwall carbon nanotube (MWCNT) on woven carbon-reinforced epoxy.Design/methodology/approach Flexural, hardness and Izod impact tests were used to evaluate MWCNT effect on the epoxy by adding different amounts, 0.2, 0.4, 0.6, 0.8 and 1 wt. %, of MWCNT, to be compared with pure epoxy.FindingsThe results showed that 0.8 wt.% gives the highest strength. The experimental results of 0.8 wt.% MWCNT reinforced carbon composite was compared with the finite element model under blister test, and the results showed high similarities.Originality/valueEvaluation of the reliability and the advantages of MWCNT considering the high aspect ratio and high tensile strength, which is more than 15 times compared to steel, MWCNT enhances the strength, stiffness and toughness of epoxy used as a matrix in repairing pipelines, which leads to an increase in the resistance of composite materials against oil internal pressure before delamination.
Robust pose estimation for ship block assembly feature based on large-scale scanning
Authors: Tang Chuyu , Chen Genliang , Wang Hao , Yu Yangfan 
Published: July 2023

Purpose
Hull block assembly is a vital task in ship construction. It is necessary to obtain the actual poses of the assembly features to guide further block alignment. Traditional methods use single-point measurement, which is time-consuming and may lead to loss of key information. Thus, large-scale scanning is introduced for data acquisition, and this paper aims to provide a precise and robust method for retrieving poses based on point set registration.

Design/methodology/approach
The main problem of point registration is to find the correct transformation between the model and the scene. In this paper, a vote framework based on a new point pair feature is used to calculate the transformation. First, a special edge indicator for multiplate objects is proposed to determine the edges. Subsequently, pair features with an edge description are noted for every point. Finally, a voting scheme based on agglomerative clustering is implemented to determine the optimal transformation.

Findings
The proposed method not only improves registration efficiency but also maintains high accuracy compared to several commonly used approaches. In particular, for objects composed of plates, the results of pose estimation are more promising because of the compact pair feature. The multiple ship longitudinal localization experiment validates the effectiveness in real scan applications.

Originality/value
The proposed edge description performs a better detection for the edges of multiplate objects. The pair feature incorporating the edge indicator is more discriminative than the original template, resulting in better robustness to outliers, noise and occlusions.
How does emotional intelligence influence self-efficacy among customer service representatives in Pakistan? Mediatory effects of emotional labour
Authors: Khan Mukaram Ali , Butt Rimsha Ashfaq , Nawab Saba , Zubair Syed Sohaib 
Published: July 2023

PurposeThis study intends to explore the influence of emotional intelligence on employee self-efficacy in Pakistan's telecom industry. Besides, it explores the mediating effect of emotional labor (surface acting and deep acting) between them. This study also tests the relationship between emotional labor (surface acting and deep acting) and self-efficacy in the customer care of Pakistan's telecom division.Design/methodology/approachThe study leads forward with a positivist approach to obtain data in two different waves as a time lag study from the big five telecom companies operating in Pakistan. The data was collected from 270 employees working in Customer Services in the Telecom sector.FindingsThe results reveal that there exists a positive relationship between emotional intelligence and self-efficacy in customer care employees in Pakistan's telecommunication division sector. Moreover, emotional labor (deep acting) partially mediates the relationship between emotional intelligence and self-efficacy, and surface acting could not mediate the relationship among the employees of customer care in Pakistan's telecom division.Originality/valueManagement of emotions at the workplace has been an immensely vital area in managing the performance of employees, especially in customer-centric jobs, where dealing with customers is the prime focus and achieving customer satisfaction is the utmost outcome. There is limited evidence of the relationship between emotional intelligence and self-efficacy specifically in the customer care of the Telecom sector.
Establishment of a new reverse genetics system for respiratory syncytial virus under the control of RNA polymerase II
Authors: Takahashi Tatsuki , Ueno Shiori , Sugiura Yoshiro , Shimizu Kenta , Kamitani Wataru 
Published: July 2023

AbstractA reverse genetics system for the respiratory syncytial virus (RSV), which causes acute respiratory illness, is an effective tool for understanding the pathogenicity of RSV. To date, a method dependent on T7 RNA polymerase is commonly used for RSV. Although this method is well established and recombinant RSV is well rescued from transfected cells, the requirement for artificial supply of T7 RNA polymerase limits its application. To overcome this, we established a reverse genetics system dependent on RNA polymerase II, which is more convenient for the recovery of recombinant viruses from various cell lines. First, we identified human cell lines with high transfection efficiency in which RSV can replicate effectively. Two human cell lines, Huh‐7 and 293T, permitted the propagation of recombinant green fluorescent protein–expressing RSV. Our minigenome system revealed that efficient transcription and replication of RSV occurred in both Huh‐7 and 293T cells. We then confirmed that recombinant green fluorescent protein–expressing RSV was rescued in both Huh‐7 and 293T cells. Furthermore, the growth capability of viruses rescued from Huh‐7 and 293T cells was similar to that of recombinant RSV rescued using the conventional method. Thus, we succeeded in establishing a new reverse genetics system for RSV that is dependent on RNA polymerase II.
Utilization of ambient noise seismic interferometry to retrieve P‐wave reflections at Soma coal basin, Western Turkey
Authors: Cankurtaranlar Ali , Demirbağ Emin 
Published: July 2023

AbstractFollowing ambient noise seismic interferometry principles, we retrieved virtual zero‐offset vertical seismic profile shot gather using continuous seismic records obtained simultaneously during an active‐source data acquisition study from Soma coal basin, Western Turkey. We treated the data to include pure ambient noise by eliminating earthquakes, surface sweeps and quarry explosions due to mining activities. We have implemented a series of data processing steps, including spectral normalization and filtering to increase the signal‐to‐noise ratio. We produced a zero‐offset virtual shot gather by cross‐correlation and cross‐coherence methods in a coal basin for the first time and we observed the P‐wave first arrivals and reflections from the deepest coal layer (km2). Our results demonstrate that the ambient noise seismic interferometry method can serve as an alternative approach for seismic imaging and monitoring in areas where the use of active seismic sources is limited due to field conditions, provided that there are sufficient and appropriate noise sources at the wellhead.
Pregnancy, parturition and postpartum considerations among patients with vulvar lichen sclerosus: A retrospective cross‐sectional online survey
Authors: Shaffer Alyssa B. , Cigna Sarah T. , Pope Rachel , Krapf Jill M. 
Published: July 2023

AbstractObjectiveCharacterise VLS and obstetric considerations among women during pregnancy, parturition and postpartum.DesignRetrospective cross‐sectional online survey, 2022.SettingInternational, English‐speakers.PopulationSelf‐identified individuals aged 18–50 diagnosed with VLS with symptom onset prior to pregnancy.MethodsParticipants recruited from social media support groups and accounts, completed a 47‐question survey including yes/no, multiple answer, and free‐text responses. Data were analysed with frequency, means and the Chi‐square test.Main outcome measuresVLS symptom severity, mode of delivery, perineal laceration, source and sufficiency of information provided about VLS and obstetrics, anxiety about delivery, and postpartum depression.ResultsOf 204 responses, 134 met inclusion criteria, encompassing 206 pregnancies. Mean respondent age was 35 years (SD 6) and mean age of VLS symptom onset, diagnosis and birth, was 22 (SD 8), 29 (SD 7) and 31 (SD 4) years, respectively. Symptoms decreased in 44% (n = 91) of pregnancies and increased during the postpartum period in 60% (n = 123). In all, 67% (n = 137) of pregnancies resulted in vaginal birth and 33% (n = 69) in caesarean birth. Anxiety for delivery due to VLS symptoms was reported by 50% (n = 103); 31% (n = 63) experienced postpartum depression. Of respondents previously diagnosed with VLS, 60% (n = 69) used topical steroids prior to pregnancy, 40% (n = 45) were treated during pregnancy and 65% (n = 75) postpartum. In all, 94% (n = 116) reported receiving an insufficient amount of information on the topic.ConclusionIn this online survey, we found reported symptom severity remained unchanged or decreased during pregnancy, but increased postpartum. Use of topical corticosteroids decreased during pregnancy compared with before and after pregnancy. Half of the respondents reported anxiety regarding VLS and delivery.
Multiple interaction networks reveal that Lepidoptera larvae and adults prefer various host plants for diet and pollination
Authors: WANG Xiangping , FU Xiao , SHI Miaomiao , XUE Chunquan , YANG Jiazhi , ZHAO Zhongtao , LI Shijin , TU Tieyao 
Published: July 2023

AbstractPlant–Lepidoptera interactions are often studied using the pollination or herbivore networks only. Lepidoptera species are involved in two types of plant–insect interactions because they are herbivores as larvae and pollinators as adults. The study of entangled networks is critical, since the interaction of different networks can affect the overall network and community stability. Here, we studied the interaction of plants and Lepidoptera on the Yongxing Island, South China Sea. A plant–lepidopteran pollination network and a plant–lepidopteran herbivore network were built by using data from flower–pollinator and leaf–herbivore interactions. We then combined the two networks into a single network. We measured plant composition similarity within each sub‐network and across sub‐networks for Lepidoptera species. Our findings indicate that the plant–Lepidoptera pollination network and the herbivory network share significant proportions of Lepidoptera but small proportions of plant assemblages. The pollination network had higher nestedness and connectance than the herbivore network. Agrius convolvuli was the most specialized species, while Zizina otis had the highest species strength in the pollination network. Most Lepidoptera species were highly specialized in the herbivore network and their importance positively correlated across the two networks. Furthermore, there was no dietary composition similarity between the two networks for most Lepidoptera species. Our findings highlight the visible structural difference between the pollination and the herbivore networks. Adult Lepidoptera selects different plants for oviposition and feeding, a strategy that may benefit their reproduction and survival by sustaining adequate resources for their two life stages and the diversity of both plants and insects in oceanic island communities.
Parasitic flies alter the dietary preference of grasshoppers
Authors: GUAN Huanhuan , ZHANG Shangyun , YANG Nan , HUANGPU Yifei , LAN Bin , NIKAS Karl J. , WU Xinwei , SUN Shucun 
Published: July 2023

AbstractParasitism is known to affect the behavior of host species to enhance parasite dispersal and transmission. However, host behavioral responses to parasitism unrelated to parasite dispersal and transmission have been much less studied. The objective of this study was to determine whether grasshopper hosts infected and uninfected with a parasitic fly (Blaesoxipha sp.) differ in terms of the nutrient content of the diet they consume. We investigated the dietary preferences of two grasshopper species (i.e. Asulconotus chinghaiensis and Chorthippus fallax) in terms of the C/N composition of plant species consumed, and determined whether this affected the egg production of unparasitized and parasitized grasshoppers by flies in a Tibetan alpine meadow. The composition of plants consumed differed significantly between the unparasitized and parasitized grasshoppers. Specifically, the abundance of N‐rich legumes was lower and that of high C/N grasses was higher in the diet of the parasitized compared to the unparasitized grasshoppers. Diet N content was higher and C/N was lower in the diet of unparasitized grasshoppers, and parasitized females produced fewer eggs than their unparasitized conspecifics. Future enquiries are needed to understand the specific mechanisms underlying these dietary differences. The effects of parasites on the fitness–associated behavior of hosts should be studied more broadly to better understand parasite evolution and adaptation.
Computerized nailfold video‐capillaroscopy in type 2 diabetes: A cross‐sectional study on 102 outpatients
Authors: Lisco Giuseppe , Triggiani Vincenzo 
Published: July 2023

AbstractBackgroundType 2 diabetes (T2D) is a chronic disease that negatively affects vascular health. A careful assessment of chronic complications, including microcirculation, is mandatory. The computerized nailfold video‐capillaroscopy (CNVC) accurately examines the nailfold microvasculature, but its suitability in T2D is currently under investigation.AimsTo describe nailfold microvasculature in T2D patients regarding the level of glucose control and chronic microvascular and macrovascular complications.MethodsThis is a cross‐sectional study on 102 consecutive and unselected outpatients with T2D who had undergone CNVC examination. The examination was carried out by using an electronic video‐capillaroscope with 300x magnification. Capillaroscopic appearance and capillary changes were described according to well‐established parameters. Capillaroscopic parameters were compared between patients with poor glucose control (HbA1c ≥7%) and those with better glucose control (HbA1c <7%) and between patients with chronic complications and those without. Chronic complications were deduced from the anamnestic, laboratory, and instrumental data and the five‐item International Index of Erectile Function (IIEF‐5) questionnaire.ResultsNailfold capillaries in patients with HbA1c ≥7% were thicker (p = .019) and longer (p = .021) than in those with better glucose control. Ectasias (p = .017) and microaneurysms (p = .045) were more frequently observed in patients with HbA1c ≥7.0% than those with HbA1c <7.0%. Patients with ED, compared to those without, had a lower frequency of bizarre‐shaped capillaries (p = .02). Microaneurysms (p = .02) were more frequently described in patients with carotid stenosis (>20%) than those without.ConclusionRelevant nailfold microvascular alterations were observed in T2D, most of which were associated with poor glycemic control, ED, and carotid stenosis. Further investigation is needed to recognize the role of CNVC in predicting the onset and evolution of chronic complications and monitoring the effectiveness of antihyperglycemic treatments on microcirculation.