bluuebunny/crossref_metadata_2025_split huggingface dataset:
Treatment with M51R Vesicular Stomatitis Virus Induces Clonal Antitumor CD8+ T Cell Expansion in Colon Cancer
Authors: Godoy-Calderon Maria Jose , Gauchat Eric , Stewart John H. 
Published: July 2023

Abstract
Developing new and effective treatments for patients with metastatic colorectal cancer is crucial, as this condition is the fourth leading cause of cancer-related deaths. The potential of the M51R vesicular stomatitis virus (M51R VSV) as an oncolytic virus for various malignancies, including colorectal cancer, is being explored by our group and others. However, the immune response to this treatment is poorly understood. To address this knowledge gap, we conducted a study using a syngeneic murine model of colorectal cancer by administering M51R VSV at two doses and analyzing the resulting immune response. We found that both doses of M51R VSV induced a robust immune response, with overexpression of genes associated with NK cell function, antigen processing and presentation, and CD8+ T cell phenotype and function. CyTOF analysis showed an increased CD8+ T cell frequency and decreased G-MDSCs and FoxP3+CD25- Treg cells. TCR sequence analysis revealed clonal expansion of a-CT26 CD8+ T cells targeted against tumor-associated antigens, making combination therapy with CAR T cells a promising approach. Our work also suggests that combination therapy with M51R VSV and immune checkpoint inhibitors may be beneficial. These findings provide a strong foundation for advancing M51R VSV-based therapies for metastatic colorectal cancer in a population of patients with limited immunotherapeutic options.
Wagner VS Keynes: A cointegration analysis of Pakistan
Authors: Mushtaq Shahzad Mushtaq , Hafeez Abida Hafeez , Ahmad Tourqeer Ahmad 
Published: July 2023

Abstract
The real GDP and government consumption expenditures have been a popular discussion by several macroeconomists. Most of them were Wagner, Keynes, and others. The current study intuitively investigated Wagner's and Keynesian law's applicability to Pakistan from 1970 to 2021. Six versions of Wagner's law likewise Peacock-Wiseman (1961), Pryor (1968), Musgrave (1969), Goffman (1968), Gupta-Michas (1967), and Mann (1980) have been tested. The empirical results of the OLS model endorsed that Wagner’s Law is applicable to its variants like Peacock-Wiseman (1961), Pryor (1968), Goffman (1968), Gupta-Michas (1967), whereas Musgrave (1969), and Mann (1980) are inapplicable for Pakistan. To investigate the long-run cointegration of each Wagner version, the Johansen and Juselius (1990) cointegration test has been used. For all formulations of Wagner's law, cointegration does not exist. The Granger causality result revealed that only three versions have bi-direction causality and favored the Keynesian rule. The results differ from Wager’s rule. The study conveys the message to the policymaker that formed a set of comprehensive policies for the increase in general government final consumption expenditure toward an increase in national income. Developing countries should follow the Keynes law.
JEL Code: C10, H50, O10, O54
Dubbing as a Pedagogical Tool: An Experimental Study on Eleventh-Grade Students at SMAN 8 Samarinda
Authors: Arbain Arbain , Rohman Abdul , Sonia  
Published: July 2023

This study was conducted to determine the efficacy of the dubbing method on the speaking ability of eleventh-grade SMAN 8 SAMARINDA students. This research is related to the findings of previous studies, which continue to indicate that many students lack adequate speaking skills. This study employs experimental research to determine whether the dubbing method is effective or ineffective for teaching students how to communicate. The study was conducted six times, once during each of the pre- and post-tests and four times during the experiment. The obtained data is based on the pre- and post-test scores of the students. The author concludes, based on the research conducted, that the use of the dubbing method in learning is effective in enhancing students' speaking skills, as indicated by their test scores. Furthermore, the calculation of the paired sample t-test reveals a significant effect, as indicated by the sig value. 0.01 0.05, therefore Ho is rejected, so it can be inferred that the dubbing method is effective on the speaking ability of SMA Negeri 8 Samarinda eleventh graders.
Da’wah values in the opening ceremony video of the World Cup Qatar 2022 (A John Fiske’s semiotic analysis)
Authors: Fikri Fikri , Septiyatik Dyta , Andri La Ode , Umamah Mudhiah 
Published: July 2023

This study aims to identify the three levels of semiotics based on John Fiske's semiotic theory and to explain da'wah values in the opening video of the Qatar 2022 World Cup. This study uses a descriptive method with an interpretive qualitative research data approach. The data were collected by watching the video and taking screenshots. The data were categorized and analyzed based on John Fiske's semiotic theory. The results show that there are da'wah values including faith, sharia, and morals. In addition, the three levels of signs conveyed by John Fiske are reflected in the costumes of actors, singers who cover their genitals (reality level), angels, lighting, music, sounds (representative level), love for animals or other living things, mutual respect between religions, races. culture, hospitality, and Arab nationalism (ideology level). As the opening ceremony of the World Cup is a moment where all eyes will be on, that was a great opportunity to deliver the ideology and broadcast the da'wah values. Therefore, the da'wah values can be shared massively compared to when da'wah is delivered orally. This study contributes to the development of a culture-based da'wah model, which is in accordance with the principles of a friendly and universal Islam. ***Penelitian ini bertujuan untuk mengidentifikasi tiga level semiotika berdasarkan teori semiotika John Fiske dan menjelaskan nilai-nilai dakwah dalam video pembukaan Piala Dunia Qatar 2022. Penelitian ini menggunakan metode deskriptif dengan pendekatan data penelitian kualitatif interpretatif. Data dikumpulkan dengan menonton video dan mengambil screenshot. Data dikategorikan dan dianalisis berdasarkan teori semiotika John Fiske. Hasil penelitian menunjukkan bahwa terdapat nilai-nilai dakwah yang meliputi akidah, syariah dan akhlak. Selain itu, tiga level tanda yang disampaikan John Fiske tercermin dari kostum aktor, penyanyi yang menutup aurat (level realitas), angle kamera, tata cahaya, musik, suara (level representasi), kasih sayang kepada hewan atau makhluk hidup lainnya, saling menghormati antar agama, ras, budaya, keramahtamahan, dan nasionalisme Arab (level ideologi). Karena, upacara pembukaan Piala Dunia merupakan momen di mana semua mata akan tertuju, maka hal tersebut merupakan kesempatan yang baik untuk menyampaikan ideologi dan menyebarkan nilai-nilai dakwah. Dengan demikian, nilai-nilai dakwah dapat disebarkan secara masif dibandingkan dengan dakwah yang disampaikan secara lisan. Kajian ini berkontribusi bagi pengembangan model dakwah berbasis kebudayaan, yang sesuai dengan prinsip Islam yang ramah dan universal.
Study of da'wah texts on muslim.or.id: The perspective of Sara Mills' critical discourse analysis
Authors: Nur Rifqi Syauqi , Riyadi Agus 
Published: July 2023

The massive transformation towards digitalization has brought about many innovative media approaches in preaching, such as the emergence of preaching websites and other platforms. The ease and fast process of publication have resulted in diverse texts of preaching, each with its unique characteristics. One of these websites is muslim.co.id, which focuses on discussing the virtues of men and glorification. This research is a qualitative study utilizing the critical discourse analysis model proposed by Sara Mills. The findings of this study reveal that the choice of words or phrases used and the focus of several articles on the Muslim.co.id website tend to exhibit a strong patriarchal tendency. This is evident through the gender issues in the texts and the superiority of men. Gender issues identified in the analysis include the subordination of women, stereotyping, and neglecting. This study contributes to efforts to encourage the presence of egalitarian online religious media in accordance with religious (Islamic) principles that reject all forms of injustice. ***Transformasi besar besaran menuju digital memunculkan banyak inovasi media dakwah seperti hadirnya situs dakwah ataupun dalam platform yang lainnya. Kemudahan serta proses yang cepat untuk publikasi berdampak pada teks dakwah yang semakin beragam dengan keunikannya masing masing. Salah satu situs tersebut ialah muslim.co.id. Situs media dakwah tersebut mempunyai corak dakwah yang cukup konsen dalam membahas keutamaan laki laki dan glorifikasinya. Penelitian ini merupakan penelitian kualitatif dengan pendekatan critical discourse analysis model Sara Mills. Hasil dari penelitian ini mengungkapkan bahwa diksi atau kalimat yang dipakai serta konsen dari beberapa artikel yang ada di situs Muslim.or.id memuat tendensi patriarkal yang cukup lekat. Hal tersebut dibuktikan dengan objektifikasi perempuan dalam sebuah teks dan superioritas laki laki. Adapun isu gender yang dapat dideteksi ialah subordinasi perempuan, stereotiping, dan neglecting. Kajian ini berkontribusi bagi upaya mendorong hadirnya media keagamaan online yang egaliter sesuai dengan prinsip keagamaan (Islam) yang menolak segala bentuk ketidakadilan.
Community perceptions, participation, and satisfaction with existing Water Resource Management Plans: a case study of a polluted water system in South Africa
Authors: Maruapula K. , Yessoufou K. Y. , Modley L. S. 
Published: July 2023

Abstract
Globally, there has been increased competition and demand between different water uses to find new and innovative approaches towards managing water resources. This has resulted in a dire need for an integrated approach which needs different sectors to achieve future action on water and sustainable development. Therefore, the aim of the present study was to understand community perspectives of the function and management of the highly eutrophic Roodeplaat Dam (RD) and its tributaries. The required data was collected through interviews and surveys in the surrounding communities. The results of the study showed that in terms of community perceptions, more highly educated people tend to qualify the quality of water as very bad and their perceptions on the potential effects of poor water quality were correlated to gender. People's satisfaction level of the current management plan was negatively correlated to employment status. Surprisingly, the community's involvement in the management and use of water resources in the Roodeplaat Catchment Area were correlated to their ethnicity. Some key recommendations from this study included the development of an ongoing community-based water management plan which adopts a bottom-top approach which incorporated community perspectives and opinions into final decision-making process.
Environmental drivers and ecological implications of a ctenophore swarm: a case study from the Bay of Bengal, northern Indian Ocean
Authors: Siddique Alfisa , Bhowal Aishee , Purushothaman Jasmine , Madhusoodhanan Rakhesh , Banerjee Dhriti 
Published: July 2023

Abstract

Ctenophores are quick responders to coastal environmental changes and play a crucial role in marine food web dynamics. We report the environmental drivers of a ctenophore swarm (Pleurobrachia spp.) and associated ecological changes in estuarine and coastal waters of the Sundarbans mangrove–estuarine complex in the northern Bay of Bengal (BoB). Plankton and fish samples were collected from estuarine and coastal waters at the peak of estuarine outflow in the northeast monsoon (NEM). Sampling locations at the estuarine mouth witnessed ctenophores (Pleurobrachia pileus and Pleurobrachia globosa) in swarming proportions. Multivariate statistical analysis revealed significant differences in hydrographical and biological properties between the swarm and non-swarm areas. The sea surface salinity, ammonium, and mesozooplankton (MSP) density were positively correlated while microzooplankton (MCZ) density was negatively correlated with the ctenophore swarm. Fish caught from swarm locations, dominated by microbial food web consisted of species of less market value, while those from the non-swarm locations, dominated by conventional plankton food web consisted mainly of commercially important species. Thus, in the first-ever record from a commercially important fishing ground in the BoB, this study provides evidence of how a ‘dead end’ plankton predator affects the plankton food web organization and fisheries in tropical coastal waters.
Tunnel water burst disaster management engineering based on artificial intelligence technology – taking Yonglian Tunnel in Jiangxi Province as the object in China
Authors: Li Dandan , Xu Haowen , Jiang Ting , Ding Hong , Xiang Yong 
Published: July 2023

Abstract
Due to the influence of the groundwater system, mountain rock layers, climate rainfall, and tunnel length and depth, underground tunnels (UT) are prone to water inrush (WI) disasters, thus leading to delays and obstacles in construction projects. This paper takes the Yonglian Tunnel as the research objective and explores the water and mud inrush disasters that occurred from July to August 2012. The Yonglian Tunnel is a control project of the Jilian Expressway in Jiangxi Province. This paper aims to study and analyze the WI disaster management of the UT using artificial intelligence technology, and to deepen the understanding of its causes. It will affect the factors, hazards, and related disaster management engineering methods of the UT WI disaster. By establishing a back-propagation neural network model and a radial basis function neural network model, the risk of WI disasters in tunnels, the degree of harm caused by WI, and the ability to control them were predicted and analyzed, and the stability and error values of the models were compared.
UNVEILING THE ANTICANCER EFFECT OF SYRINGIC ACID AND ITS DERIVATIVES IN HEPATOCELLULAR CARCINOMA
Authors: M. LAVANYA , SRINIVASAN PERUMAL , PADMINI RAMAKRISHNAN 
Published: July 2023

Objective: Traditionally, syringic acid has been used as a medicine for a wide range of ailments. The current study aims to look at its potential therapeutic benefits against experimentally generated hepatocellular carcinoma in wistar rats, and in order to better understand how syringic acid interacts with apoptosis proteins in hepatocellular carcinoma, the molecular docking has been performed by using argus lab 4.0.1 software.
Methods: The hepatocellular carcinoma (HCC) targets such as P53, BAX, Bcl-2, capase 3 and 9, Cytochrome-C, TNFα, NFκB, and TRAF1 were docked with syringic acid. The syringic acid derivatives such as acetosyringone, syringaldehyde, syringol, sinapinic acid, sinapyl alcohol, sinapaldehyde, sinapine, and canolol were docked with caspase3. Thirty male wistar rats were randomly assigned to five groups. The control group was given normal saline. Group 2 obtained a single oral dose of diethylnitrosamine (DEN) (200 mg/kg) body weight. Groups 3, 4, and 5 received diethylnitrosamine (DEN), and furthermore daily administration of syringic acid orally at 25 mg/kg for 14 w. Serum samples were used for the determination of liver marker levels. Liver tissue samples were used for histopathological determination, apoptotic and anti-apoptotic protein expression.
Results: The syringic acid and its derivatives exhibited excellent energy values and satisfied the drug-likeness property of Lipinski’s rule of five. Syringic acid significantly reduced the serum liver marker levels, and in contrast, it increased the expression of apoptotic proteins in the diethylnitrosamine (DEN)-induced treated group.
Conclusion: It has been demonstrated that syringic acid had a protective effect against diethylnitrosamine (DEN)-induced hepatocellular carcinoma in Wistar rats, and a docking study exhibited that it has good anticancer activity.
A Study of Islamic Worldview Follows an Education System: Reveals the Spiritual Tendencies of Adolescents
Authors: Nuriman Nuriman , Yuliza Yuliza , Yusnaini Yusnaini 
Published: July 2023

The main goal of the study was to identify adolescents' worldviews following Traditional Education, Boarding Schools, and Senior High School types. The variables were examined with One-way ANOVA and T-Test analysis to identify the aspects of worldly and spiritual which involved 390 in the age range of 16-21 years and consisted of 150 males and 240 females of adolescents. The systematic random sampling and questionnaire version of the MRPI were employed for the data collection procedure. The worldly aspect is found insignificantly and the spiritual significantly differs following educational types. It was the basis of forming the adolescents' spirituals of diversity.
Localized Versus Non-Localized data: its Effect on Maize Nutrient Removal, Efficiencies and Budgets at a Global Scale.
Authors: Ludemann Cameron Ian , Hijbeek Renske , Loon Marloes van , Murrell T Scott , Dobermann Achim , Ittersum Martin van 
Published: July 2023

Estimates of cropland nutrient budgets and nutrient use efficiencies at
national to global scales generally rely on average nutrient
concentrations for quantifying nutrients removed in crop yield and
by-products. Given the relevance of crop removal in nutrient budgets, it
is important that more locally relevant coefficients or models are
developed. However, many countries do not have sufficient data from farm
surveys or field experiments. Using maize as an example, we assessed how
much a country’s estimated nutrient removal is affected when using
either global (Tier 1), regional (Tier 2) or national/sub-national (Tier
3) estimates of harvest index and nutrient concentration of crop
products and residues.
Estimates of cropland removal of nitrogen, phosphorus and potassium
varied substantially (up to 52%), depending on which Tier approach was
used. This had a substantial influence on national nutrient budgets and
nutrient use efficiencies. Our study shows the large uncertainty
associated with current nutrient offtake estimates. If national data
(Tier 2) are not available, Tier 3 offers a methodology to overcome such
data limitations through the application of models, trained on localized
but widely available data for countries. We recommend to use Tier 2 or
Tier 3 approaches once they have been evaluated against real on-farm
data. The presented methodology can be applied to other crops and
nutrients to improve cropland nutrient budgets and estimates of crop
nutrient use efficiencies.
Predicting Federal Contractor Misconduct
Authors: Alford Laura C. , Hansen Stephen C. , Hermis Judith M. 
Published: July 2023

ABSTRACT
Between 1995 and 2021, the United States’ Federal Government imposed $162.5 billion in penalties upon government contractors who had engaged in improper behavior as part of the procurement process. Despite the enormity of contractor misbehavior, the characteristics associated with contractor misconduct are relatively underexplored in academic literature. In this study, we examine whether and to what extent firm characteristics predict federal government contractor misbehaviors, which range from minor statutory violations to fraud. We document a consistent association between contractor characteristics (size and total amount of government contracts received), contract-specific characteristics (service-type contracts and awarding agencies GSA and DOE), and the act of committing misconduct. Misconduct severity increases in size and total amount of government contracts, is not affected by service contracts, and has an inverse U-shape for government agencies. Taken together, our results suggest that characteristics of the contractor, contract, and government agency are predictably associated with committing procurement misconduct.
Data Availability: Data are available from the public sources cited in the text.
JEL Classifications: H11; H57; M41.
Implementación de investigación cuantitativa en elaboración de manual solución de sequias por explotación de aguas en la región Cinco Manantiales
Authors: De Hoyos Vázquez Félix Fernando , Tobías Macías Francisco Fabián , Hernández Ochoa Norma Eleonor , Losoya Sifuentes Diego de Jesús 
Published: July 2023

La elaboración del presente artículo de investigación aborda la problemática de la falta de agua en un periodo de estudio comprendido entre el 1 de enero de 2022 y el 30 de agosto del mismo año. Se pone de manifiesto la gravedad de la escasez de agua en la zona de los cinco manantiales y municipios cercanos, consecuencia de la explotación de este recurso para la elaboración y procesamiento de productos de empresas cerveceras ubicadas en esta región.
Para este estudio, se utilizaron herramientas estadísticas descriptivas y se llevó a cabo la recopilación de datos provenientes de notas informativas, ecológicas y meteorológicas. Esto permitió conocer de manera más precisa y concreta las métricas de la problemática.
A medida que avanzó la recopilación de información y datos, el artículo tomó un sentido diferente y se convirtió en un artículo informativo técnico. Dada la falta de seguimiento y de antecedentes sobre el tema, se tomó la iniciativa proactiva de implementar un pre-modelo de protocolo basado en toda la información recopilada. Este serviría de guía, métrica y plantilla para la elaboración o certificación de un protocolo oficial.
Lo anterior sirve como fuente informativa para los miembros de la comunidad y material de referencia para las ingenieras ambientales o ecológicas de las empresas y autoridades de los departamentos correspondientes en las mismas localidades.
Problematika Proses Pembelajaran Daring dalam Mata Pelajaran Sejarah di SMA Pembangunan Padang
Authors: Saputra Hazim , Ofianto Ofianto 
Published: July 2023

Penelitian ini dilatarbelakangi oleh temuan yang menunjukkan adanya problem atau masalah yang terjadi dalam proses pembelajaran daring, sehingga ditemukan beberapa guru dan peserta didik yang tidak memahami pembelajaran di dalam pelaksanaan pembelajaran daring. Penelitian ini bertujuan untuk mengetahui seberapa besar problem atau masalah yang dihadapi oleh sekolah, guru dan peserta didik dalam proses pelaksanaan pembelajaran daring dalam mata pelajaran sejarah. Metode yang digunakan dalam penelitian ini adalah Mix Method dengan pendekatan kuantitatif dan kualitatif. Pengumpulan data menggunakan angket, wawancara serta dokumentasi. Hasil penelitian yang ditemukan bahwa problem atau masalah guru dan siswa dalam pelaksanaan proses pembelajaran daring di mata pembelajaran sejarah di SMA Pembangunan Padang terlihat bermasalah dimana terlihat dari persentase rata-rata guru sebesar 52,8% dan siswa sebesar 60,72%. Dalam segi persiapan, sekolah terkendala dengan penyusunan jadwal mata pelajaran, sedangkan bagi guru terkendala dengan menggunakan metode pembelajaran yang tepat. Dalam segi pelaksanaan guru terkendala untuk membuat siswa fokus dalam pembelajaran, sedangkan siswa terkendala dalam memahami materi yang diajarkan oleh guru. Dalam evaluasi pembelajaran, guru terkendala dalam penerimaan tugas siswa karena siswa tidak memahami materi pelajaran, sedangkan siswa terkendala dalam penerimaan tugas yang terlalu banyak. Jadi dapat disimpulkan dari hasil penelitian, guru dan siswa terkendala dalam menyampaikan materi dan penerimaan tugas yang terlalu banyak.