bluuebunny/crossref_metadata_2025_split huggingface dataset:
Wie demenzsensibel sind Hausärzt*innen? – eine explorierende Betrachtung von Einstellungs‑, Handlungs- und Kompetenzindikatoren zur Demenzversorgung
Authors: Wangler Julian , Jansky Michael 
Published: September 2023

Zusammenfassung
Hintergrund
Zur Erkennung und Betreuung demenzieller Erkrankungen bietet die Hausarztmedizin gute Voraussetzungen. Dennoch wird immer wieder Kritik an der Effektivität der allgemeinärztlichen Demenzversorgung geübt. Bislang haben nur wenige Untersuchungen den Versuch unternommen, ein ganzheitliches Bild über den Status quo der hausärztlichen Demenzversorgung abzubilden und dabei die Erfahrungs- und Handlungsperspektive von Hausärzt*innen zu fokussieren.

Ziel der Arbeit
Die Studie zielte darauf ab, anhand einer gebündelten Betrachtung relevanter Betreuungs- und Versorgungsdimensionen (Konstrukt „Demenzsensibilität“) mögliche Stärken und Schwachpunkte der hausarztbasierten Demenzversorgung zu identifizieren.

Material und Methoden
Mittels einer Online-Befragung wurden im Jahr 2022 insgesamt 2257 als Behandler*innen aktive Hausärzt*innen in Hessen und Baden-Württemberg befragt. Zur Feststellung von signifikanten Unterschieden zwischen zwei Gruppen kam ein t‑Test bei unabhängigen Stichproben zum Einsatz. Zudem wurde auf das Verfahren der Faktorenanalyse zurückgegriffen.

Ergebnisse
Die Befragten hielten es für wichtig, dass Hausärzt*innen in Fragen der Betreuung demenziell erkrankter Personen präsent sind. Die Ärzt*innen äußerten den Wunsch, Patient*innen und Angehörige aktiv zu begleiten. Zugleich wird deutlich, dass viele Hausärzt*innen sowohl praktisch-diagnostische Schritte der (leitliniengerechten) Identifizierung einer Demenz als auch das konsequente Krankheitsmanagement inklusive der Antizipierung von Versorgungs- bzw. Therapiebedarfen als herausfordernd erlebten. Ferner zeigt sich, dass ein erheblicher Teil der Stichprobe sich nur bedingt zutraute, einschlägige Hilfs- und Unterstützungsangebote zu überblicken. Ein durchgehender Befund besteht darin, dass Ärzt*innen mit urbanem Praxissitz sowie mit geriatrischer Weiterbildung teils beträchtliche Kenntnis‑, Orientierungs- und Sicherheitsvorteile in Bezug auf die Demenzversorgung aufwiesen.

Schlussfolgerung
Im Licht der Befunde scheint es v. a. geboten, die geriatrische Kompetenz von Hausärzt*innen zu stärken. Zudem erscheint es essenziell, diese stärker über Kooperations- und Hilfsstrukturen im Bereich der Demenzversorgung aufzuklären und zu integrieren.
Identification and geomorphic characterization of fluvial knickzones in bedrock rivers from Courel Mountains Geopark
Authors: García Horacio 
Published: September 2023

AbstractThe gradient characteristics of Courel Mountains Geopark bedrock rivers were examined. Unlike alluvial rivers, bedrock rivers have been the great forgotten of fluvial geomorphology globally. Based on the decreasing rate of gradient with increasing measurement length, a relative steepness was obtained as indicator of knickzone. Supported by GIS techniques and DEMs, the changes in slope along the longitudinal profile of the rivers were detected. The number of the extracted knickzones rises to 325, which means a frequency of knickzones of 0.467 km−1. The total length of the knickzones is 285 km, representing about half of the drainage network as knickzone (47%). The mean height, the length, and the gradient of all the knickzones were ~ 110 m, ~ 880 m, and 0.178 m·m−1, respectively. There is no distribution pattern and the knickzones are everywhere, although they are more present in reaches with NW–SE direction and order 1. Several environmental factors were crossed to know more about the occurrence and knickzones characteristics, suggesting that density and direction of fractures regulate the number and the trajectory of the knickzones, while the lithology controls the singularity of the forms. The geomorphological and the topographical characteristics of the bedrock rivers make them high ecological, scenic, landscape, and recreational value. Findings from this study can be also used by managers to develop and/or improve strategies for conservation, valorisation, and how to approach the tourist who visits the Geopark. Scientific tourism can offer a unique and educational travel experience, allowing participants to learn about bedrock rivers and knickzones.
Differential diagnosis between dilated cardiomyopathy and ischemic cardiomyopathy based on variational mode decomposition and high order spectra analysis
Authors: Han Yuduan , Zhao Yunyue , Lin Zhuochen , Liang Zichao , Chen Siyang , Zhang Jinxin 
Published: September 2023

AbstractThe clinical manifestations of ischemic cardiomyopathy (ICM) bear resemblance to dilated cardiomyopathy (DCM). The definitive diagnosis of DCM necessitates the identification of invasive, costly, and contraindicated coronary angiography. Many diagnostic studies of cardiovascular disease have tried modal decomposition based on electrocardiogram (ECG) signals. However, these studies ignored the connection between modes and other fields, thus limiting the interpretability of modes to ECG signals and the classification performance of models. This study proposes a classification algorithm based on variational mode decomposition (VMD) and high order spectra, which decomposes the preprocessed ECG signal and extracts its first five modes obtained through VMD. After that, these modes are estimated for their corresponding bispectrums, and the feature vector is composed of fifteen features including bispectral, frequency, and nonlinear features based on this. Finally, a dataset containing 75 subjects (38 DCM, 37 ICM) is classified and compared using random forest (RF), decision tree, support vector machine, and K-nearest neighbor. The results show that, in comparison to previous approaches, the technique proposed provides a better categorization for DCM and ICM of ECG signals, which delivers 98.21% classification accuracy, 98.22% sensitivity, and 98.19% specificity. And mode 3 always has the best performance among single mode. The proposed computerized framework significantly improves automatic diagnostic performance, which can help relieve the working pressure on doctors, possible economic burden and health threaten.
Gebrechlichkeit („frailty“) und Operabilität: die geriatrische Sicht
Authors: Kressig Reto W. 
Published: September 2023

ZusammenfassungDas durchschnittliche Alter sowie die Zahl von zu operierenden älteren Patienten nehmen seit Jahren stetig zu, weshalb eine sorgfältige Operabilitätsabklärung hinsichtlich Prognose und möglichen peri- und postoperativen Komplikationen grossen Sinn macht. Eine auf Alltagsfunktionalität basierte Gebrechlichkeitsklassifikation (wie die nach Fried) kann hier nicht nur schnell Klarheit hinsichtlich möglich einzugehender Risiken schaffen, sondern auch die Indikation für ein weiterführendes multidimensionales geriatrisches Assessment oder die gezielte Einleitung therapeutischer Massnahmen zur Verminderung des operativen Risikos bedeuten. Kann kein standardmässiges Gebrechlichkeitsassessment durchgeführt werden, können auch einfache Screeningtests wie der „timed up & go test“ und seine weiterentwickelte Version des „imagined timed up & go test“ auf mögliche postoperative Risiken motorischer und kognitiver Komplikationen hinweisen.
DNA methylation-dependent epigenetic regulation of Verticillium dahliae virulence in plants
Authors: Chen Yun-Ya , Zhu Chen , Zhao Jian-Hua , Liu Ting , Gao Feng , Zhang Ying-Chao , Duan Cheng-Guo 
Published: September 2023

AbstractAs a conserved epigenetic mark, DNA cytosine methylation, at the 5’ position (5-mC), plays important roles in multiple biological processes, including plant immunity. However, the involvement of DNA methylation in the determinants of virulence of phytopathogenic fungi remains elusive. In this study, we profiled the DNA methylation patterns of the phytopathogenic fungus Verticillium dahliae, one of the major causal pathogens of Verticillium wilt disease that causes great losses in many crops, and explored its contribution in fungal pathogenicity. We reveal that DNA methylation modification is present in V. dahliae and is required for its full virulence in host plants. The major enzymes responsible for the establishment of DNA methylation in V. dahliae were identified. We provided evidence that DNA methyltransferase-mediated establishment of DNA methylation pattern positively regulates fungal virulence, mainly through repressing a conserved protein kinase VdRim15-mediated Ca2+ signaling and ROS production, which is essential for the penetration activity of V. dahliae. In addition, we further demonstrated that histone H3 lysine 9 trimethylation (H3K9me3), another heterochromatin marker that is closely associated with 5-mC in eukaryotes, also participates in the regulation of V. dahliae pathogenicity, through a similar mechanism. More importantly, DNA methyltransferase genes VdRid, VdDnmt5, as well as H3K9me3 methyltransferase genes, were greatly induced during the early infection phase, implying that a dynamic regulation of 5-mC and H3K9me3 homeostasis is required for an efficient infection. Collectively, our findings uncover an epigenetic mechanism in the regulation of phytopathogenic fungal virulence.
Love and Relationship Satisfaction as a Function of Romantic Relationship Stages
Authors: Cassepp-Borges Vicente , Gonzales Joseph E. , Frazier Annabelle , Ferrer Emilio 
Published: September 2023

AbstractThe strong influence of the components of love in the relationship satisfaction is very described in the scientific literature. The current cross-sectional study evaluated the associations between participants’ love and relationship satisfaction across different phases of a relationship. For this propose, we recruited a sample of 1102 Brazilian participants, including 756 (68.6%) women and 346 (31.4%) men (mean age = 25.52 years, SD = 7.98), from 12 Brazilian states and the Federal District. Participants’ relationship was coded in order of bond levels: 0 - unrequited relationship, 1 - non-established relationship, 2 - dating, 3 - living together or engaged, and 4 - married. A linear regression analysis indicated that the influence of passion on relationship satisfaction is higher, and the influence of commitment is lower, in more advanced phases of one’s relationship. Multilevel regression showed the role of bond, interacting with the dimensions of love on the prediction of relationship satisfaction. The associations between types of love and relationship satisfaction differ across relationship stages. While the influence of passion and intimacy on relationship satisfaction grows across the relationships’ stages, the influence of commitment decreases. This study also suggests that type of relationship can be understood as an ordinal variable, instead of categorical.
Biological properties of surface modified 316 LVM steel
Authors: Dyner Aneta , Major Roman , Major Łukasz , Szewczenko Janusz , Lukaszkowicz Krzysztof , Barabaszová Karla Čech , Krzywiecki Maciej , Basiaga Marcin 
Published: September 2023

Abstract
This paper aimed to investigate the selected physicochemical and biological properties of titanium dioxide thin films deposited by atomic layer deposition on 316LVM stainless steel dedicated for cardiovascular implants. The main challenge in surface modification of these implants is the complexity of the processes taking place in the circulatory system. The atomic layer deposition was carried out for a number of cycles 500 and temperature 200 °C for 316LVM stainless steel substrate. The surface topography and surface microstructure were examined. Mouse fibroblasts L929 and Human Dermal Fibroblasts (NHDF-Ad) were used for cytotoxicity assays. The following biocompatibility aspects were investigated in vitro: direct cytotoxicity, hemolysis, platelet activation and aggregation, and pro-inflammatory cytokine levels. The titanium dioxide thin films inherited the substrate topography. The surface microstructure was amorphous with the typical layer by layer growth. The film improved the in vitro cell response in terms of cell viability. The cells were also able to proliferate and adhere; however, differences in the cell morphology and the distribution of cell nuclei were observed. The host cell damage was not noted in terms of lactate dehydrogenase levels. The proposed surface modification reduced the hemolysis index and did not significantly affect platelet activation and aggregation. Acute cytotoxicity of the thin films is not predicted basing on the in vitro pro-inflammatory cytokine assay. The results of the biological tests may be basis for further biological assessment proving the full biocompatibility of the proposed surface modification dedicated for specific cardiovascular implants.
RETRACTED ARTICLE: A Multilevel Fuzzy Evaluation of Cross-Border E-Commerce Profitability Model
Authors: Zou Qijun 
Published: September 2023

AbstractWith the continuous development of economic globalisation, China has established free trade zones (FTA). To promote the diversification of cross-border e-commerce in FTA and increase industry competitiveness, the Porter's Five Forces model (PFFM) was used to analyse the profit model of e-commerce enterprises. Based on fuzzy logic, an evaluation model for the profit model of cross-border e-commerce was constructed, and this evaluation model was used to evaluate the profitability of cross-border e-commerce. The results show that the evaluation model constructed based on fuzzy logic can better reflect the profitability of enterprises. The accuracy of multilevel fuzzy evaluation is above 80% every year, with the highest accuracy being in 2017, and the evaluation accuracy for that year is 98.5%. The study of a cross-border e-commerce profit evaluation model based on multilevel fuzzy evaluation method can better reflect the profitability of enterprises and help them clarify their future development direction.
Representativeness of whole-genome sequencing approaches in England: the importance for understanding inequalities associated with SARS-CoV-2 infection
Authors: Twohig Katherine A. , Harman Katie , Zaidi Asad , Aliabadi Shirin , Nash Sophie G. , Sinnathamby Mary , Harrison Ian , Gallagher Eileen , Groves Natalie , Schwach Frank , Pearson Clare , Thornton Alicia , Myers Richard , Chand Meera , Thelwall Simon , Dabrera Gavin 
Published: September 2023

Abstract
Whole-genome sequencing (WGS) information has played a crucial role in the SARS-CoV-2 (COVID-19) pandemic by providing evidence about variants to inform public health policy. The purpose of this study was to assess the representativeness of sequenced cases compared with all COVID-19 cases in England, between March 2020 and August 2021, by demographic and socio-economic characteristics, to evaluate the representativeness and utility of these data in epidemiological analyses. To achieve this, polymerase chain reaction (PCR)-confirmed COVID-19 cases were extracted from the national laboratory system and linked with WGS data. During the study period, over 10% of COVID-19 cases in England had WGS data available for epidemiological analysis. With sequencing capacity increasing throughout the period, sequencing representativeness compared to all reported COVID-19 cases increased over time, allowing for valuable epidemiological analyses using demographic and socio-economic characteristics, particularly during periods with emerging novel SARS-CoV-2 variants. This study demonstrates the comprehensiveness of England’s sequencing throughout the COVID-19 pandemic, rapidly detecting variants of concern, and enabling representative epidemiological analyses to inform policy.
Exploring potential mechanisms for zinc deficiency to impact in autism spectrum disorder: a narrative review
Authors: Conti M.V. , Santero S. , Luzzi A. , Cena H. 
Published: September 2023

AbstractAutism spectrum disorder (ASD) is a heterogeneous and complex group of life-long neurodevelopmental disorders. How this clinical condition impacts an individual’s intellectual, social and emotional capacities, contributing to alterations in the proprioceptive and sensory systems and increasing their selective attitude towards food, is well described in the literature. This complex condition or status exposes individuals with ASD to an increased risk of developing overweight, obesity and non-communicable diseases compared with the neurotypical population. Moreover, individuals with ASD are characterised by higher levels of inflammation, oxidative stress markers and intestinal dysbiosis. All these clinical features may also appear in zinc deficiency (ZD) condition. In fact, zinc is an essential micronutrient for human health, serving as a structural, catalytic and regulatory component in numerous physiological processes. The aim of this narrative review is to explore role of ZD in ASD. Factors affecting zinc absorption, excretion and dietary intake in this vulnerable population are taken into consideration. Starting from this manuscript, the authors encourage future research to investigate the role of ZD in ASD. The perspective is to potentially find another missing piece in the ‘ASD clinical puzzle picture’ to improve the health status of these individuals.
Quantitative Relationship Between Current Pulses and Associated Low‐Frequency Magnetic Fields During Initial Stage of Rocket‐Triggered Lightning
Authors: Li Xiao , Lu Gaopeng , Wang Ziyi , Jiang Rubin , Fan Yanfeng , Zi Yucheng , Liu Feifan , Qamar Kainat , Nambalirwa Alice , Shi Tao , Zhu Baoyou 
Published: September 2023

AbstractThe quantitative relationship between the channel‐base current and the associated low‐frequency magnetic field (B‐field) during the early stage of rocket‐triggered lightning was examined based on field experiments and numerical simulation. There is a good correlation between the current pulse and the corresponding B‐field pulse in terms of amplitude and duration. In specific, the duration of current pulse is approximately proportional to that of the corresponding B‐field pulse for precursors and initial upward leaders; as for the pulse amplitude, the linear correlation is more apparent for the initial upward leaders when compared to the precursors, with the ratio of B‐field pulse and current pulse between 1.7 and 2.0, which is always greater than that (0.97–1.32) for the precursors. A response function is established to show the quantitative relationship in the time domain between the current pulse and the associated B‐field pulse, which is considered as the convolution of the current pulse and the response function. Meanwhile, the current waveform can be obtained if the measured B‐field pulse is de‐convolved with the response function. The simulation results are in good agreement with the measurement, which proves that our approach is accurate and efficient to quantify the relationship between the current and the B‐field pulse of the initial leader discharges.
Reply to Comment by Wei and Shen on “Seismic Velocity Variations at Different Depths Reveal the Dynamic Evolution Associated With the 2018 Kilauea Eruption”
Authors: Liu Zhiqiang , Liang Chuntao , Huang Huixuan , Wang Chaoliang , Cao Feihuang 
Published: September 2023

AbstractWe would like to thank Wei and Shen (2023, https://doi.org/10.1029/2022GL102596) (W23) for their comments on our recent article on GRL. In their comments, Wei and Shen argued that tremor signal on the right side of the cross‐correlation function (CCF) of PAUD‐STCD is from Kilauea crater, and they suggested that the observed time‐delay after eruption might be attributed to the noise source change and other factors. After checking the data and the code carefully, we recognize that signal on the right side of CCF of PAUD‐STCD may be due to seismicity from the Kilauea crater. However, we demonstrate here that it does not affect our conclusions.
Seasonal Link Between Deepwater Overflow Through the Luzon Strait and Deep Western Boundary Current in the Philippine Sea
Authors: Xu Qinbo , Zhang Linlin , Xiao Xin , Zhou Chun , Wang Fan , Hu Dunxin 
Published: September 2023

AbstractThe cold dense water from the Pacific sinks to the deep South China Sea (SCS) through the Luzon Strait, driving the abyssal and overturning circulations in the SCS, and affecting the Indonesia Throughflow and its associated heat and freshwater fluxes. Combining the ocean bottom pressure data and the hydrographic data, we reveal the seasonal link between Luzon Strait deepwater overflow (LSDO) and deep western boundary current (DWBC) in the Philippine Sea. The seasonal variation in the DWBC dominates the pressure difference between the Pacific and the SCS by adjusting the temperature field on the east side of the Luzon Strait, which in turn contributes to the seasonal variation in the LSDO. The enhanced DWBC in summer/autumn carries more relatively cold water from the high latitudes to the east of the Luzon Strait, increasing the local density and leading to the enhancement of the LSDO in autumn.
The Impact of Changes in Sea Level and East Asian Monsoon on Sediment Transport on the Sunda Shelf Since the Last Deglaciation
Authors: Wu Kaikai , Liu Shengfa , Shi Xuefa , Colin Christophe , Zhang Hui , Bassinot Franck , Liu Zhifei , Fang Xisheng , Miska Serge , Nouet Julius , Pinna‐Jamme Rosella , Dapoigny Arnaud , Rahim Mohamed Che Abd. , Khokiattiwong Somkiat , Kornkanitnan Narumol 
Published: September 2023

AbstractThe Sunda Shelf plays a key role in the sedimentation of the southern South China Sea (SCS). However, the impact of past climate changes on sediment transfer to the Sunda Shelf and the southern SCS is still unresolved. Here, we present new data on grain size, clay mineralogy, and Sr‐Nd isotopes of three marine cores, river sediments, and surface sediments of the Sunda Shelf. The results indicate that clay fractions of the central Sunda Shelf and the Gulf of Thailand derived mainly from the Mekong River and the rivers of northern Thailand since the last deglaciation. Significant changes in sediment sources are observed at 7.5 cal ka BP. From 13.3 to 7.5 cal ka BP, sediments in the Gulf of Thailand mainly originated from the rivers of northern Thailand, with contributions from the Mekong River increasing after 7.5 cal ka BP. An opposite shift is observed in the central Sunda Shelf. Such variations in the spatial distribution result from a combination of sea level and East Asian monsoon effects. After 7.5 cal ka BP, less Mekong River sediments were transported southeastwards into the southern SCS, and more sediments were gradually trapped within the delta and transported in a southwesterly direction into the Gulf of Thailand due to intense East Asian winter monsoon, which forced a strong southwestward coastal current. Our results demonstrate the important impact of East Asian winter monsoon strengthening and sea level rise in the mid‐Holocene, which can change sediment sources and transport processes on the Sunda Shelf.