bluuebunny/crossref_metadata_2025_split huggingface dataset:
A multi-source heterogeneous data-driven method for the site selection of elderly care facilities
Authors: Wang Hao , Wang Zongshui 
Published: June 2023

Abstract
In the site selection of elderly care facilities era, the traditional methods of site selection for elderly care facilities are subjective, the data sources of methods are single, and the research objects of the methods are not realistic, this paper presents a multi-source heterogeneous data-driven method for the site selection of elderly care facilities. This method takes the Xicheng and Dongcheng districts of Beijing as the research objects. On the grid scale of 500m*500m, six features of population factors, economic level, traffic accessibility, medical conditions, the convenience of life, and natural factors are constructed through multi-source data. Using an integrated algorithm, the location of elderly care facilities is predicted quantitatively, and the priority of features is sorted. The research found that: (1) The model in this paper predicts more accurately than traditional models (2) the number of education facilities, proportion of green areas, medical conditions, traffic accessibility, and the number of shopping facilities are the main features for the site selection of elderly care facilities in Xicheng and Dongcheng districts. This method can also provide references for the site selection of other facilities.
GLS1 mediates SREBP-1 to promote lipid metabolism in hepatocellular carcinoma through PI3K/AKT/mTORC1 signaling pathway
Authors: Sun Yaocheng , Shen Ying , Yan Yongmin , Xi Jianbo , Luo Wei , Liu Chuanlei , Tang Jianjun 
Published: June 2023

Abstract
Cancer cells are characterized by altered metabolism. As the key enzyme in cancer cells that promotes glutamine catabolism to glutamate and ammonia, glutaminase 1 (GLS1) is highly associated with a variety of human malignancies. However, its role in lipid metabolism in hepatocellular carcinoma (HCC) remains to be revealed. Our findings show that GLS1 is not only significantly highly expressed in HCC, but also negatively correlates with clinical prognosis. Further studies showed that GLS1 promotes lipid accumulation and new fatty acid synthesis in HCC. In addition, GLS1 promotes lipid accumulation and cell growth by upregulating the increased expression of sterol regulatory element binding protein 1 (SREBP-1) and SREBP cleavage-activating protein (SCAP). Mechanistically, GLS1 promotes lipid metabolism in HCC cells through PI3K/AKT/mTOR activation. Taken together, our study suggests that GLS1 mediates SREBP-1 to promote lipid metabolism in HCC through the PI3K/AKT/mTORC1 signaling pathway, which may be a novel idea that GLS1 has the potential to be a biomarker for HCC as well as a target for drug therapy.
Ferroptosis Inhibitor Ferrostatin-1 Attenuates Morphine Tolerance Development in Rats by Inhibiting Dorsal Root Ganglion Neuronal Ferroptosis
Authors: Dirik Hasan , Taşkıran Ahmet Şevki , Joha Ziad 
Published: June 2023

Abstract
OBJECTIVES: This investigation aimed to assess the impact of ferrostatin-1 on the progression of morphine tolerance and elucidate the underlying mechanisms involved.
METHODS: The rats in this experiment were categorized into six groups: Control, pantoprazole, morphine, pantoprazole + morphine, morphine tolerance, and pantoprazole + morphine tolerance. The antinociceptive action was evaluated using both the hot plate and tail-flick tests. Subsequent to the completion of the analgesic tests, tissue samples were gathered from the dorsal root ganglia (DRG) for subsequent analysis. The levels of glutathione, glutathione peroxidase 4 (GPX4), and nuclear factor erythroid 2-related factor 2 (Nrf2), along with the measurements of total oxidant status (TOS) and total antioxidant status (TAS), were assessed in the tissues of the dorsal root ganglion (DRG).
RESULTS: Following tolerance development, the administration of ferrostatin resulted in a notable decrease in morphine tolerance. Additionally, ferrostatin treatment resulted in elevated levels of glutathione, GPX4, Nrf2, and TOS, while concurrently causing a decrease in TAS levels.
CONCLUSION: The outcomes of our study establish that ferrostatin-1 has the capability to mitigate the progression of morphine tolerance by suppressing ferroptosis and decreasing oxidative stress in neurons of the dorsal root ganglia (DRG). These results suggest that Ferrostatin-1 holds promise as a potential therapeutic intervention to prevent or attenuate the formation of morphine tolerance.
Evaluating the ability of agroforestry systems to mimic forests with remote sensing data in the Amazon
Authors: Fiel Luciane Gomes , Aviz Matheus Dias , Sousa Marina Costa , Rayol Breno Pinto , Lima Aline Meiguins , Souza Everaldo Barreiros , Anjos Luciano J S 
Published: June 2023

Abstract
Agroforestry systems (AFSs) are a form of land use capable of sequestering and storing carbon in their perennial structure, while ensuring income distribution and food security in biodiversity-friendly landscapes. Given this, such a productive activity has great potential as an adaptive measure in the face of the ongoing climate change. The logic of this activity is supported by the theoretical framework of biomimetics, even if in an intuitive and non-declared way, where there is a deliberate intention that agroecosystems should imitate natural ecosystems in their structure and functioning. Based on this premise, the objective of this study is to evaluate whether the AFS in the municipality of Tomé-Açu, inserted in the Amazon biome, are capable of mimicking primary forests in terms of their structure and functioning over two decades of observation in a spatially explicit. To achieve this objective, we used the Enhanced Vegetation Index (EVI) calculated on the Google Earth Engine (GEE) platform for primary forests and agroecosystems in the municipality of Tomé-Açu between 2000 and 2020 annually. In addition, we used aboveground biomass (AGB) estimates derived from remote sensors to assess whether there were functional differences in carbon storage between the two evaluated treatments. We observed that using the EVI, there is no statistically significant difference between AFS and primary forests, although there are relevant differences in terms of biomass. Our results indicate that AFS can be structurally similar to mature forests, corroborating studies that point to a similarity in the ability to store carbon. From the results of our methodological approach, we conclude that agroforestry systems can represent a relevant opportunity for mitigating the socio-environmental effects of climate change.
Phylogenomic Analysis of Dichrocephala benthamii and Comparative Analysis within Tribe Astereae (Asteraceae)
Authors: Chen Hui , Luo Junjia , Liu Xiaofeng , Li Tingyu , Qu Tianmeng , Li Bo , Fu Zhixi 
Published: June 2023

Abstract
Dichrocephala benthamii C. B. Clarke has long been used as traditional Chinese medicine. However, the chloroplast (cp) genome of D. benthamii is poorly understood so far. In this study, we have sequenced and analyzed the cp genome of D. benthamii. The results show that the cp genome is 152,350 bp in length, with a pair of inverted repeat regions (IRa and IRb, each 24,982 bp), a large single-copy (LSC) region comprising 84,136 bp, and a small single-copy (SSC) region comprising 18,250 bp. The GC content of the cp genome was 37.3%. A total of 134 genes were identified, including 87 protein-coding genes (CDS), 38 tRNA genes, 8 rRNA genes, and 1 pseudogene (ycf1). The plastome includes 87 simple repeats and 48 long repeats. The phylogenetic analysis reveals D. benthamii is the basal group of Astereae. Therefore, we confirm that the taxa of Astereae emerges from southern Africa and dispersed to other big continents. The results of this study are a significant contribution to the field of genetics and species identification related to D. benthamii.
Mycobacterium tuberculosis resides in lysosome-poor monocyte-derived lung cells during chronic infection
Authors: Zheng Weihao , Chang I-Chang , Limberis Jason , Budzik Jonathan , Zha Beth Shoshana , Howard Zachary , Chen Lucas , Ernst Joel 
Published: June 2023

Abstract

Mycobacterium tuberculosis (Mtb) persists in lung myeloid cells during chronic infection. However, the mechanisms allowing Mtb to evade elimination are not fully understood. Here, we determined that in chronic phase, CD11clo monocyte-derived lung cells termed MNC1 (mononuclear cell subset 1), harbor more live Mtb than alveolar macrophages (AM), neutrophils, and less permissive CD11chi MNC2. Transcriptomic and functional studies of sorted cells revealed that the lysosome biogenesis pathway is underexpressed in MNC1, which have less lysosome content, acidification, and proteolytic activity than AM, and less nuclear TFEB, a master regulator of lysosome biogenesis. Mtb infection does not drive lysosome deficiency in MNC1. Instead, Mtb recruits MNC1 and MNC2 to the lungs for its spread from AM to these cells via its ESX-1 secretion system. The c-Abl tyrosine kinase inhibitor nilotinib activates TFEB and enhances lysosome function of primary macrophages and MNC1 and MNC2 in vivo, improving control of Mtb infection. Our results indicate that Mtb exploits lysosome-poor monocyte-derived cells for in vivo persistence, suggesting a potential target for host-directed tuberculosis therapy.
The simulation of nonlinear magneto-heat coupling model approached by finite element method
Authors: Xu Tianliang , Fan Xiaomin , Yao Changhui 
Published: June 2023

Abstract

This article is devoted to the exploration of finite element methodfor magneto-heat coupling model, where the eddy current problem and the heat equation are coupled together with the heat convection and the radiation effects. The main contribution is consist of three parts. Firstly, the decoupled scheme is established by applying backward Euler discretization in time and Nédélec-Lagrange finite element in magnetic-temperature field, respectively. Secondly, the existence uniqueness and stability of the numerical solutions are proved by applying the theory of monotoneoperators. Thirdly, the error estimate with the convergent order $O(\tau+h^{\min\{ r,1\}}), \frac{1}{2} < r ≤ 1 under a lower regular assumption. Eventually, two numerical examples are provided.
2008 MSC: 65M60, 65M15, 35Q60, 35B45.
Corrosion Behaviour of Fe-based and Ni-based Alloys in Wet CO2 Gas with and without Chloride Deposits at 750°C
Authors: Cai Yuchen , Zhang Zhe , Zhang Jianqiang , Gleeson Brian , Young David J. 
Published: June 2023

Abstract
Corrosion behaviours of Fe-25Cr, Fe-25Cr-2Mn-1Si, Fe-25Cr-20Ni, 310SS, Ni-25Cr, and Ni-25Cr-2Mn-1Si (all in wt. %) with and without NaCl-KCl deposits in Ar-60%CO2-20%H2O gas at 750oC were studied. Without salt deposits, Fe-25Cr performed protectively, while Fe-25Cr-20Ni and Ni-25Cr underwent breakaway oxidation with multi-layered scales formed. Adding alloy elements Si + Mn increased the corrosion resistance of all alloys by forming additional Mn-rich oxides and silica. Surface deposits of NaCl-KCl accelerated corrosion, forming porous Fe-rich oxide nodules for Fe-25Cr and thick, porous scales and internal oxidation zones for all other alloys. The protective effect of Si + Mn alloying disappeared in the presence of chlorides. Limited intergranular carbides were observed for all alloys in the gas-only condition. The extent of carburisation increased with the presence of chloride deposits for all Fe-based alloys, but remained unchanged for Ni-based alloys. Corrosion of these alloys at 750oC is compared with that at 650oC. The effect of chlorides in volatilising metals at 750oC is discussed.
First report of Anopheles stephensi in Southern Ethiopia
Authors: Hawaria Dawit , Kibret Solomon , Zhong Daibin , Lee Ming-Chieh , Lelisa Kidane , Bekele Belayneh , Birhanu Muntasha , Mengesha Mathe , Solomon Hiwot , Yewhalaw Delenesaw , Yan Guiyun 
Published: June 2023

Abstract
Background
Anopheles stephensi is an emerging exotic invasive urban vector of malaria in East Africa. The World Health Organization recently announced an initiative to take concerted actions to limit this vector's expansion by strengthening surveillance and control in invaded and potentially receptive territories in Africa. This study sought to determine the geographic distribution of An. stephensi in southern Ethiopia.
Methods
A targeted entomological survey, both larvae and adult, was conducted in Hawassa city, Southern Ethiopia between November 2022 and February 2023. Anopheles Larvae were reared to adults for species identification. CDC light traps and BG Pro traps were used overnight both indoor and outdoor at selected houses to collect adult mosquitoes in the study area. Prokopack Aspirator was employed to sample indoor resting mosquitoes in the morning. Adults of An. stephensi was identified using morphological keys, and then confirmed by PCR.
Results
Larvae of An. stephensi were found in 28 (16.6%) of the 169 potential mosquito breeding sites surveyed. Out of 548 adult female Anopheles mosquitoes reared from larvae, 234 (42.7%) were identified to be An. stephensi morphologically. A total of 449 female anophelines were caught, of which 53 (12.0%) were An. stephensi. Other anopheline species collected in the study area included An. gambiae (s.l.), An. pharoensis, An. coustani, and An. demeilloni.
Conclusion
The study, for the first time, confirmed the presence of An. stephensi in southern Ethiopia. The presence of both larval and adult stages of this mosquito attest that this species established a sympatric colonization with native vector species such as An. gambiae (s.l.) in Southern Ethiopia. The findings warrant further investigation on the ecology, behavior, population genetics, and role of An. stephensi in malaria transmission in Ethiopia.
Reduction by symmetries of contact mechanical systems on Lie groups
Authors: Simoes Alexandre Anahory , Colombo Leonardo , de León Manuel , Marrero Juan Carlos , de Diego David Martín , Padrón Edith 
Published: June 2023

Abstract
We study the dynamics of contact mechanical systems on Lie groups that are invariant under a Lie group action. Analogously to standard mechanical systems on Lie groups, existing symmetries allow for reducing the number of equations. Thus, we obtain Euler-Poincaré-Herglotz equations on the extended reduced phase space g × ℝ associated with the extended phase space TG × ℝ, where the configuration manifold G is a Lie group and g its Lie algebra. Furthermore, we obtain the Hamiltonian counterpart of these equations by studying the underlying Jacobi structure. Finally, we extend the reduction process to the case of symmetry-breaking systems which are invariant under a Lie subgroup of symmetries.
AMS Mathematics Subject Classification (2020). Primary 70G45, 70G65, 70G75; Secondary 53D05, 53D10, 53D17.
Developing prognostic nomograms to predict overall survival and cancer-specific survival in synchronous multiple primary colorectal cancer based on the SEER database
Authors: Zhang Xiangyu , Hu Yanpeng , Deng Kai , Ren Wanbo , Zhang Jie , Liu Cuicui , Ma Baoqing 
Published: June 2023

Abstract
Background:
Synchronous multiple primary colorectal cancer (SMPCC) is a rare subtype of CRC, characterized by the presence of two or more primary CRC lesionssimultaneously or within 6 months from the detection of the first lesion. We aim to develope a novel nomogram to predict OS and CSS for SMPCC patients using data from the SEER database.
Methods:
The clinical variables and survival data of SMPCC patients between 2004 and 2018 were retrieved from the Surveillance, Epidemiology, and End Results (SEER) database. Appropriate inclusion and exclusion criteria were established to screen the enrolled patients. Univariate and multivariate cox regression analyses were used to identify the independent risk factors for OS and CSS. The performance of the nomogram was evaluated using the concordance index (C-index), calibration curves, and the area under the curve (AUC) of a receiver operating characteristics curve (ROC). A decision curve analysis (DCA) was generated to compare the net benefits of the nomogram with those of the TNM staging system.
Results:
A total of 6772 SMPCC patients were enrolled in the study and randomly assigned to the training (n = 4670) and validation (n = 2002) cohorts. Multivariate cox analysis confirmed that race, marital status, age, histology, tumor position, T stage, N stage, M stage, chemotherapy, and the number of dissected LNs were independent prognostic factors.The C-index values for OS and CSS prediction were 0.716 (95%CI: 0.705–0.727) and 0.718 (95%CI: 0.702–0.734) in the training cohort, and 0.760 (95%CI: 0.747–0.773) and 0.749 (95%CI: 0.728–0.769) in the validation cohort. The ROC and calibration curves indicated that the model had good stability and reliability. Decision curve analysis revealed that the nomograms provided more significant clinical net benefit than the TNM staging system.
Conclusion:
We developed a novel nomogram for clinicians to predict OS and CSS and could be used to optimize the treatment in SMPCC patients.
The Fundamental Plane of FSRQs with the Black HoleSpin-Mass Energy
Authors: Zhang Xu , Gao Quan-Gui 
Published: June 2023

Abstract
Abstract The Fundamental Plane(FP) for the Active Galactic Nuclei (AGNs) is found by previous worksin recent years. However the mass of Black Hole (MBH)for this previous works is the total black hole mass also known as the dynamical mass, Mdyn. The result offundamental plane may be influenced by BH spin. Itmotivated us for a new variable considering the effectof black hole spin. In this work, we add the black holespin-mass energy(Mspin) as a new variable which has aclose relation to the jet for the supermassive black hole.We collected a sample of 62 flat-spectrum radio quasars(FSRQs) to build a new fundamental plane of blazarswith gamma ray luminosity(Lγ), X-ray luminosity(Lx)and the BH spin-mass energy. The fundamental plane (logLγ=0.662−0.193+0.193logLX+0.495−0.154+0.154logMspin+14.579−7.140+7.140 with R-Square=0.783) show that thespin-mass energy has a better relation comparing tothe mass of black hole. The result indicates that Mspinshould be considered as a important variable for thefundamental plane of Blazars. It might help us to get abetter understanding on the Blandford-Znajek processin FSRQs.
A quasi-experimental study to estimate effectiveness of Seasonal Malaria Chemoprevention in Aweil South County in Northern Bahr El Ghazal, South Sudan.
Authors: Khan Jamshed , Sans Maria Suau , Okot Francis , Ayuiel Abubaker Rom , Magoola Jonathan , Rassi Christian , Huang Sikai , Mubiru Denis , Bonnington Craig , Baker Kevin , Ahmed Julla , Nnaji Chuks , Richardson Sol 
Published: June 2023

Abstract
Background Seasonal malaria chemoprevention (SMC) is an effective intervention to prevent malaria in children in locations where the burden of malaria is high and transmission is seasonal. There is growing evidence suggesting that SMC with sulfadoxine-pyrimethamine and amodiaquine can retain its high level of effectiveness in East and Southern Africa despite resistance concerns. This study aims to generate evidence on the effectiveness of SMC when delivered under programmatic conditions in an area with an unknown antimalarial drug resistance profile in the Northern Bahr el-Ghazal region of South Sudan.Methods We conducted a non-randomised quasi experimental study comparing an intervention county with a control county. Five monthly SMC cycles were delivered between July and November 2022, targeting about 19,000 children 3–59 months old. Data were obtained from repeated cross-sectional household surveys of caregivers of children aged 3–59 months using cluster sampling. Wave 1 survey took place in both counties before SMC implementation; Waves 2 and 3 took place after the second and fourth monthly SMC cycles. We performed difference-in-differences analysis by fitting logistic regression models with interactions between county and wave.Results A total of 2,760 children were sampled in the study across the three survey waves in both study counties. Children in the intervention arm had 70% lower odds of caregiver-reported fever relative to those in the control arm during the one-month period prior to Wave 2 (OR: 0.30, 95%CI: 0.12–0.70, p = 0.003), and 47% lower odds in Wave 3 (OR: 0.63, 95%CI: 0.22–1.59, p = 0.306) after controlling for baseline difference between counties in Wave 1. Odds of caregiver-reported RDT-confirmed malaria were 82% lower in the previous one-month period prior to Wave 2 (OR: 0.18, 95%CI: 0.07–0.49, p = 0.001) and Wave 3 (OR: 0.18, 95%CI: 0.06–0.54, p = 0.003).Conclusion These results show high effectiveness of SMC using SPAQ in terms of reducing malaria disease during the high transmission season in children 3–59 month. Despite the promising results, we require the results from the chemoprevention efficacy cohort studies, and analysis of relevant resistance markers, to assess the suitability of SMC for this specific context.
Financial crash with a long memory of volatility: fractional volatility in a bubble atmosphere
Authors: boughabi houssam , qalli yassine el 
Published: June 2023

Abstract
Through this article we had chosen a model that takes into consideration any brutal change in prices, a downfall of prices which we had dealt with using discrete jump processes following the poissonian discrete time version of the Johansen-Ledoit-Sornette (JLS) power model as an economic study of such a phenomenon, besides this we have been so creative by adding a fractionally integrated generalized autoregressive conditional heteroscedastic (FIGARCH) shock to our model to obtain a new framework that should intuitively link crashes in the market to past memory. We went for pricing futures afterwards by discretising the filtration Ft which makes pricing possible using the augmented filtration correctly. Options are priced after in absence of arbitrage using econometrics and approximation. Bitcoin is the material of study where we have chosen a period when prices of bitcoin went down sharply to use the JLS part of our model correctly. Besides the pricing study that was the main problematic of this article, we have touched the economical side by discussing a rescue budget and ought to evaluate it to save the futures market during the bubble and at the day of the crash.
JEL Classification. C58, E44, G13.
REFORMULASI HUBUNGAN AGAMA DENGAN NEGARA: DIALOG PEMIKIRAN YUSUF AL-QARDHAWY DENGAN ULAMA KLASIK TENTANG POLITIK KENEGARAAN DAN IMPLIKASINYA BAGI PERPOLITIKAN DI INDONESIA
Authors: Mashudi Mashudi 
Published: June 2023

This research describes the formulation want state politics and religious ties with the country according to Yusuf al-Ulama Qardhawy and Classical. The results of the analysis of their thinking as outlined in his works, can be explained that Yusuf al-Qardhawy reformulate the concept of the relationship between religion and the state as well as the state political through and isti'ab syumuli method, a problem of how to resolve the impasse in state politics as well as the relationship between religion and state product classical scholars thought. Reformulation of the concept of the relationship between religion and the state is the solution to the stagnation (stagnation) patterns of thought classical scholars. The concept of state politics by Yusuf al-Ulama Classical Qardhawy and there are points in common with the Indonesian state politics in the context of the present though not totally, so that some can be implemented to control the practice of politics in Indonesia lately away from religious ethics.