bluuebunny/crossref_metadata_2025_split huggingface dataset:
Free‐water‐corrected diffusion and adrenergic/muscarinic antibodies in myalgic encephalomyelitis/chronic fatigue syndrome
Authors: Kimura Yukio , Sato Wakiro , Maikusa Norihide , Ota Miho , Shigemoto Yoko , Chiba Emiko , Arizono Elly , Maki Hiroyuki , Shin Isu , Amano Keiko , Matsuda Hiroshi , Yamamura Takashi , Sato Noriko 
Published: May 2023

AbstractBackground and PurposeFree‐water‐corrected diffusion tensor imaging (FW‐DTI), a new analysis method for diffusion MRI, can indicate neuroinflammation and degeneration. There is increasing evidence of autoimmune etiology in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). We used FW‐DTI and conventional DTI to investigate microstructural brain changes related to autoantibody titers in patients with ME/CFS.MethodsWe prospectively examined 58 consecutive right‐handed ME/CFS patients who underwent both brain MRI including FW‐DTI and a blood analysis of autoantibody titers against β1 adrenergic receptor (β1 AdR‐Ab), β2 AdR‐Ab, M3 acetylcholine receptor (M3 AchR‐Ab), and M4 AchR‐Ab. We investigated the correlations between these four autoantibody titers and three FW‐DTI indices—free water (FW), FW‐corrected fractional anisotropy (FAt), and FW‐corrected mean diffusivity—as well as two conventional DTI indices—fractional anisotropy (FA) and mean diffusivity. The patients’ age and gender were considered as nuisance covariates. We also evaluated the correlations between the FW‐DTI indices and the performance status and disease duration.ResultsSignificant negative correlations between the serum levels of several autoantibody titers and DTI indices were identified, mainly in the right frontal operculum. The disease duration showed significant negative correlations with both FAt and FA in the right frontal operculum. The changes in the FW‐corrected DTI indices were observed over a wider extent compared to the conventional DTI indices.ConclusionsThese results demonstrate the value of using DTI to assess the microstructure of ME/CFS. The abnormalities of right frontal operculum may be a diagnostic marker for ME/CFS.
Clinical performance of monolithic lithium disilicate hybrid abutment crowns over at least 3.5 years
Authors: Schubert Oliver , Goob Janosch , Schweiger Josef , Güth Jan‐Frederik , Edelhoff Daniel , Graf Tobias 
Published: May 2023

AbstractPurposeHybrid abutment crowns (HACs) made from monolithic ceramics represent an efficient option for single restorations on implants. However, long‐term data are scarce. The purpose of this clinical trial was to evaluate the survival and complication rates of CAD‐CAM fabricated HACs over a time period of at least 3.5 years.Materials and MethodsTwenty‐five patients with a total of 40 HACs made of monolithic lithium disilicate ceramic bonded to a titanium base CAD‐CAM abutment were retrospectively evaluated. All implants and screw‐retained restorations were placed and manufactured in the same department of a university hospital. Only crowns that had been in service for more than 3.5 years were included in the study. HACs were evaluated regarding technical and biological complications. Functional Implant Prosthodontic Scores (FIPS) were obtained.ResultsThe mean observation time was 5.9 ± 1.4 years. Implant survival was 100%, and HAC survival was 97.5%. Over the observation period, one crown fracture was observed, necessitating refabricating of the restoration. Three minor biological complications were found. The overall mean FIPS score was 8.69 ± 1.12 points.ConclusionsWithin the limitations of this study, monolithic screw‐retained HACs milled from lithium disilicate ceramics and bonded to titanium bases appeared to be a reliable treatment option over more than 3.5 years due to their low biological and technical complication rates.
Self‐determination and quality of life of people with intellectual and developmental disabilities: Past, present, and future of close research paths
Authors: Mumbardó‐Adam Cristina , Vicente Eva , Balboni Giulia 
Published: May 2023

AbstractIn recent decades, research in the field of intellectual and developmental disabilities has targeted self‐determination and quality of life constructs. Quality of life has been extensively studied within various theoretical frameworks. It has been used to guide the provision of appropriate support in daily life. In addition, a vast body of scientific literature has focused on the theoretical and practical underpinnings of self‐determination as a construct in itself. To understand how self‐determination is an essential supporting concept in the quality of life paradigm, this brief report unravels the complementary but unique role that each construct (quality of life and self‐determination) embodies. Furthermore, we discuss the role of self‐determination in the scientific literature and in the quality of life of people with intellectual and developmental disabilities, reflecting on how both lines of research can converge and be aligned from a common approach. The aim is to drive attention to areas of future research development that strengthen understanding of quality of life and the self‐determination construct.
Association between sickle cell disease and periodontal disease: A systematic review
Authors: da Silva Brenda Batista , Pontes Ana Emília Farias , Lemos Cleidiel Aparecido Araújo , Ortega Rose Mara 
Published: May 2023

AbstractPrevious studies have evaluated the association between sickle cell disease (SCD) and periodontal disease; however, their effect on the periodontal parameters remains unclear. This systematic review aimed to investigate whether individuals with sickle cell disease (SCD) increase the risks of periodontal disease more than those without. For the selection of eligible studies, an electronic search was conducted in the MEDLINE/PubMed, Web of Science, Cochrane Library, and Scopus databases. The meta‐analysis was based on the inversion of variance using the mean difference (MD) of the continuous outcomes. The quality assessment of included studies was performed using the JBI Critical Appraisal Tools. In total, 13 studies and 2381 participants were included in the qualitative analysis, while 9 studies were considered for the meta‐analysis. The meta‐analysis indicated that patients with SCD present similar Plaque Index, Clinical Attachment Level, Bleeding on Probing, and Probing Depth when compared to healthy patients (p > .05). However, the Gingival Index was higher for patients with SCD (p = .0002; MD: 0.20). Compared to healthy patients, patients with SCD did not have an increase in periodontal parameters, except for the gingival index. However, further well‐designed studies are recommended to reassess the association between SCD and periodontal diseases.
Economy of Shadows: The Effects of Restrictive Regulation on Religiosity in China
Authors: Francis‐Tan Andrew 
Published: May 2023

AbstractReligion is permitted in China, but its practice is tightly regulated by the state. This paper uses individual‐level longitudinal data to investigate the association between religious regulation and religious outcomes in China. Measures of regulation are constructed from instances of state action against Christians as well as Christian perceptions of unfair treatment by the government. In summary, as regulation increases, an individual is less likely to identify with a religion and less likely to say that religion is important. For those individuals without religious identification in either wave, regulation is negatively associated with religious importance. Yet, for those individuals with identification in one or two waves, regulation is either unassociated or even positively associated with importance. These findings contribute to research on regulation of religion and religion in China. More broadly, they demonstrate the state can wield considerable power over people's private lives but also that this power has limits.
Implicit function‐based continuous representation for meticulous segmentation of cracks from high‐resolution images
Authors: Chu Honghu , Long Lizhi , Guo Jingjing , Yuan Huaqing , Deng Lu 
Published: May 2023

AbstractHigh‐resolution (HR) crack images offer more detailed information for evaluating the structural condition and formulating effective maintenance or rehabilitation plans. However, the meticulous segmentation of HR crack images has been a challenge due to the limitations of mainstream deep learning algorithms that extract features in a discrete manner, as well as the constraints of computing resources. To address this issue, a novel implicit function‐integrated architecture, called the crack continuous refinement network (CCRN), was proposed for meticulous segmentation of cracks from HR images using a continuous representation manner. First, a crack continuous alignment module with a position encoding function was proposed to encode the tiny crack pixels that are easily lost in the sampling process. Then, a lightweight decoder embedded with implicit functions was customized to recover crack details from the aligned latent features and continuous position encoding information. Afterward, the gap between low‐resolution training images and HR inference results was bridged by the proposed continuous inference strategy. Finally, the robustness and practicability of the well‐trained CCRN were demonstrated by a parallel comparison and an unmanned aerial vehicle‐based field experiment.
Bacterial membrane dynamics: Compartmentalization and repair
Authors: Bramkamp Marc , Scheffers Dirk‐Jan 
Published: May 2023

AbstractIn every bacterial cell, the plasma membrane plays a key role in viability as it forms a selective barrier between the inside of the cell and its environment. This barrier function depends on the physical state of the lipid bilayer and the proteins embedded or associated with the bilayer. Over the past decade or so, it has become apparent that many membrane‐organizing proteins and principles, which were described in eukaryote systems, are ubiquitous and play important roles in bacterial cells. In this minireview, we focus on the enigmatic roles of bacterial flotillins in membrane compartmentalization and bacterial dynamins and ESCRT‐like systems in membrane repair and remodeling.
The effect of food, vitamin, or mineral supplements on chronic constipation in adults: A systematic review and meta‐analysis of randomized controlled trials
Authors: van der Schoot Alice , Creedon Alice , Whelan Kevin , Dimidi Eirini 
Published: May 2023

AbstractBackgroundOver‐the‐counter supplements are commonly used to manage chronic constipation; however, their efficacy remains unclear. We aimed to investigate the effect of food, vitamin or mineral supplements on stool output, gut transit time, symptoms, and quality of life in adults with chronic constipation via a systematic review and meta‐analysis of randomized controlled trials (RCTs).MethodsStudies were identified using electronic databases, backward citation, and hand‐searching abstracts. RCTs reporting administration of food supplements (e.g., fruit extract supplements), vitamin or mineral supplements in adults with chronic constipation were included. Studies administering whole foods (e.g., fruits) were excluded. Risk of bias (RoB) was assessed with Cochrane RoB 2.0. Relative risks (RR), mean differences (MD), or standardized mean differences (95% confidence intervals [CI]) were calculated using a random‐effects model.Key ResultsEight RCTs (787 participants) were included, investigating kiwifruit (n = 3 RCTs), senna (n = 2), magnesium oxide (n = 2), Ziziphus jujuba (n = 1), and Malva Sylvestris (n = 1) supplements. Kiwifruit supplements did not impact stool frequency (MD 0.24 bowel movements/week [−0.32, 0.80]; p = 0.40) or consistency (MD −0.11 Bristol points [−0.31, 0.09], p = 0.29). Overall, 61% responded to senna and 28% to control; however, this did not reach statistical significance (RR 2.78, [0.93, 8.27]; p = 0.07). Overall, 68% responded to magnesium oxide and 19% to control (RR 3.32 [1.59, 6.92]; p = 0.001). Magnesium oxide improved stool frequency (MD 3.72 bowel movements/week [1.41, 6.03]; p = 0.002) and consistency (MD 1.14 Bristol points [0.48, 1.79]; p = 0.0007).Conclusions and InferencesMagnesium oxide supplements are effective at improving cardinal symptoms of chronic constipation. Senna and kiwifruit supplements did not impact symptoms; however, findings were based on a small number of studies. Further research is required to investigate the effect of food supplements (e.g., kiwifruit supplements), as well as their whole food equivalents (e.g., whole kiwifruits) in chronic constipation.
The big four of plant taxonomy – a comparison of global checklists of vascular plant names
Authors: Schellenberger Costa David , Boehnisch Gerhard , Freiberg Martin , Govaerts Rafaël , Grenié Matthias , Hassler Michael , Kattge Jens , Muellner‐Riehl Alexandra N. , Rojas Andrés Blanca M. , Winter Marten , Watson Mark , Zizka Alexander , Wirth Christian 
Published: May 2023

Summary

Taxonomic checklists used to verify published plant names and identify synonyms are a cornerstone of biological research. Four global authoritative checklists for vascular plants exist: Leipzig Catalogue of Vascular Plants, World Checklist of Vascular Plants, World Flora Online (successor of The Plant List, TPL), and WorldPlants. We compared these four checklists in terms of size and differences across taxa.

We matched taxon names of these checklists and TPL against each other, identified differences across checklists, and evaluated the consistency of accepted names linked to individual taxon names. We assessed geographic and phylogenetic patterns of variance.

All checklists differed strongly compared with TPL and provided identical information on c. 60% of plant names. Geographically, differences in checklists increased from low to high latitudes. Phylogenetically, we detected strong variability across families. A comparison of name‐matching performance on taxon names submitted to the functional trait database TRY, and a check of completeness of accepted names evaluated against an independent, expert‐curated checklist of the family Meliaceae, showed a similar performance across checklists.

This study raises awareness on the differences in data and approach across these checklists potentially impacting analyses. We propose ideas on the way forward exploring synergies and harmonizing the four global checklists.
Are seven amino acid substitutions sufficient to explain the evolution of high l‐DOPA 4,5‐dioxygenase activity leading to betalain pigmentation? Revisiting the gain‐of‐function mutants of Bean et al. (2018)
Authors: Guerrero‐Rubio M. Alejandra , Walker‐Hale Nathanael , Guo Rui , Sheehan Hester , Timoneda Alfonso , Gandia‐Herrero Fernando , Brockington Samuel F. 
Published: May 2023

Summary
This work revisits a publication by Bean et al. (2018) that reports seven amino acid substitutions are essential for the evolution of l‐DOPA 4,5‐dioxygenase (DODA) activity in Caryophyllales. In this study, we explore several concerns which led us to replicate the analyses of Bean et al. (2018).
Our comparative analyses, with structural modelling, implicate numerous residues additional to those identified by Bean et al. (2018), with many of these additional residues occurring around the active site of BvDODAα1. We therefore replicated the analyses of Bean et al. (2018) to re‐observe the effect of their original seven residue substitutions in a BvDODAα2 background, that is the BvDODAα2‐mut3 variant.
Multiple in vivo assays, in both Saccharomyces cerevisiae and Nicotiana benthamiana, did not result in visible DODA activity in BvDODAα2‐mut3, with betalain production always 10‐fold below BvDODAα1. In vitro assays also revealed substantial differences in both catalytic activity and pH optima between BvDODAα1, BvDODAα2 and BvDODAα2‐mut3 proteins, explaining their differing performance in vivo.
In summary, we were unable to replicate the in vivo analyses of Bean et al. (2018), and our quantitative in vivo and in vitro analyses suggest a minimal effect of these seven residues in altering catalytic activity of BvDODAα2. We conclude that the evolutionary pathway to high DODA activity is substantially more complex than implied by Bean et al. (2018).
Cytokinin activity – transport and homeostasis at the whole plant, cell, and subcellular levels
Authors: Hu Yangjie , Shani Eilon 
Published: May 2023

SummaryCytokinins (CKs) are important plant hormones that regulate a variety of biological processes implicated in plant development and stress responses. Here, we summarize the most recent advances in discovering and characterizing the membrane transporters involved in long‐ and short‐distance translocation of CKs and their significance in CK signal activity. We highlight the discovery of PUP7 and PUP21 tonoplast‐localized transporters and propose potential mechanisms for CK subcellular homeostasis. Finally, we discuss the importance of subcellular hormone transport in light of the localization of histidine kinase receptors of CKs at the endoplasmic reticulum and plasma membrane.
Platform cooperatives and the dilemmas of platform worker‐member participation
Authors: Mannan Morshed , Pek Simon 
Published: May 2023

AbstractDespite the surge of interest in platform cooperatives, we have a limited understanding of the dynamics of platform worker‐member participation in these cooperatives. Drawing on interviews with 21 senior leaders and founders of platform worker cooperatives, we investigate the dynamics of platform worker‐member participation, finding that these cooperatives experience some successes and many challenges. We then build theory about how four distinct features of platform worker cooperatives—the facilitation of multihoming, the physically untethered nature of work, the relatively high importance of scale as a strategic imperative, and the relatively low importance of initial platform worker‐member investment—influence these participation dynamics. We find that the platform and worker cooperative organisational models are in tension with one another when brought together within a platform worker cooperative, leading to positive and negative effects on participation.
Medical considerations in the ageing implant patient
Authors: Dave Manas , Tattar Rajpal , Patel Neil 
Published: May 2023

AbstractThroughout adult life, there is a physiological decline in almost all body systems and with a greater proportion of population living to old age, dental practitioners will need to provide operative intervention in more medically complex patients. Dental implants are a common modality for the replacement of missing teeth; however, implant failure and associated disease present complex challenges to clinicians. Therefore, the aim of this narrative review is to discuss the cardiovascular, respiratory, haematological, endocrine, and musculoskeletal systems with respect to diseases affecting patients of an older age which can impact dental implant treatment.
Cryoneurolysis of alveolar nerves for chronic dental pain: A new technique and a case series
Authors: Cachemaille Matthieu , Geering Sébastien , Broome Martin 
Published: May 2023

AbstractBackgroundChronic neuropathic dental pain has a poor prognosis with a low chance of significant spontaneous improvement. Local or oral therapies may be efficient, however short in terms of duration with potential side effects. Cryoneurolysis has been described to prevent acute postoperative pain or to treat some chronic pain conditions; however, application to dental orofacial pain has not been reported so far.Case SeriesFollowing a positive diagnostic block on the corresponding alveolar nerve, neuroablation was performed using a cryoprobe on three patients suffering from persistent pain after a dental extraction and 1 after multiple tooth surgeries. The effect of treatment was assessed using a Pain Numeric Rating Scale (NRS) and determined by changes in medication dosage and quality of life at day 7 and 3 months. Two patients experienced more than 50% of pain relief at 3 months, 2 by 50%. One patient was able to wean off pregabalin medication, one decreased amitriptyline by 50%, and one decreased tapentadol by 50%. No direct complications were reported. All of them mentioned improvement in sleep and quality of life.ConclusionCryoneurolysis on alveolar nerves is a safe and easy‐to‐use technique allowing prolonged neuropathic pain relief after dental surgery.
Characteristics and outcomes of advanced melanoma patients with complete response and elective discontinuation of first‐line anti‐programmed death‐1 monotherapy: A real‐world multicentre observational cohort study
Authors: Ochenduszko Sebastian , García Sanchez Javier , Fita María José Juan , González‐Barrallo Inés , Herrero Colomina Julio , Mujika Karmele , Beveridge Roberto Diaz , Martínez Silverio Ros , Lafuente Blanca Sánchez , Tomas Alberto Cunquero , Jaime Alfonso Berrocal , Cerezuela Fuentes Pablo , Fra Pablo Luna , Peeters Alicia Gervás , Meana García José Andrés , García María Asunción Algarra , Altozano Javier Perez , Cancela Maria , Puchades Almudena Mateu , Roca Francisco Ferrando , Maiques Inmaculada Maestu 
Published: May 2023

AbstractAnti‐programmed death‐1 (anti‐PD1) treatment has significantly improved outcomes of advanced melanoma with a considerable percentage of patients achieving complete response (CR). This real‐world study analyzed the feasibility of elective anti‐PD1 discontinuation in advanced melanoma patients with CR and evaluated factors related to sustained response. Thirty‐five patients with advanced cutaneous or primary unknown melanoma with CR to nivolumab or pembrolizumab from 11 centers were included. Mean age was 66.5 years, and 97.1% had ECOG PS 0–1. 28.6% had ≥3 metastatic sites with 58.8% having M1a‐M1b disease; 8.6% had liver and 5.7% had brain metastases. At baseline, 80% had normal LDH, and 85.7% had a neutrophil‐to‐lymphocyte ratio ≤3. 74.3% of patients had CR confirmed in PET‐CT. Median duration of anti‐PD1 was 23.4 months (range 1.3–50.5). 24 months after therapy discontinuation, 91.9% of patients were progression‐free. Estimated PFS and OS at 36, 48, and 60 months from the start of anti‐PD1 were 94.2%, 89.9%, 84.3%, and 97.1%, 93.3%, 93.3%, respectively. Antibiotics use after anti‐PD1 discontinuation increased the odds of progression (OR 16.53 [95% CI 1.7, 226.03]). The study confirms the feasibility of elective anti‐PD1 discontinuation in advanced melanoma patients with CR and favorable prognostic factors at baseline.
Volatile cinnamaldehyde induces systemic salt tolerance in the roots of rice (Oryza sativa)
Authors: Huang Chung‐Chih , Lee Yun‐Ting , Ly Thach‐Thao , Wang Chong‐Yue , Chang Yao‐Tsung , Hou Ping‐Fu , Liu Zin‐Huang , Huang Hao‐Jen 
Published: May 2023

AbstractCinnamaldehyde (CA) is a volatile plant secondary metabolite that exhibits strong anti‐pathogenic activities. Nonetheless, less is known about the effect of CA on plant tolerance to abiotic stresses. In this study, we delineated the effects of CA fumigation on rice roots (Oryza Sativa L cv. TNG67) under salinity stress (200 mM NaCl). Our result showed that CA vapor significantly alleviated salinity‐induced ROS accumulation and cell death. This CA‐induced alleviation appears to be mediated primarily by the upregulation of proline metabolism genes, the rapid proline accumulation, and the decrease of Na+/K+ ratio as early as 3 h after NaCl treatment. Of note, the activities of peroxidase (POD; EC 1.11.1.7) isozymes a and b were decreased by CA fumigation, and the activities of catalase (CAT; EC 1.11.1.6) and superoxide dismutase (SOD; EC 1.15.1.1) were not significantly affected. Our findings suggest that CA vapor might be useful for priming rice roots to withstand salinity stress, which is more prevalent due to the ongoing global climate change. To the best of our knowledge, this is the first study to show modulation of macro‐ and micro‐elements as well as antioxidative factors after CA fumigation of salinity‐stressed rice roots.