bluuebunny/crossref_metadata_2025_split huggingface dataset:
MRI Appearances of Stage IA Ovarian Carcinoma
Authors: Cui Li Wen , Shen Zhi Yong 
Published: March 2023

Objective:
To analyze the MRI findings of stage IA ovarian cancer.

Methods:
The data on age distribution, clinical symptoms at onset, CA125 detection, MRI findings, including tumor volume, structure, diffusion-weighted
imaging (DWI), apparent diffusion coefficient (ADC) and enhancement, etc., of the patients with stage IA ovarian cancer, who were admitted to
Nantong tumor Hospital between 2013 and 2020 were analyzed retrospectively.

Results:
Only 11 cases of stage IA ovarian cancer were recorded. The age of patients was 30–67 (average 52) years. The initial symptoms were mostly
lower abdominal distension and abdominal pain. CA125 was 90% positive. MRI features 1. Large pelvic mass with a volume range of 23–2,009
cm3 (average 669 cm3). 2. Five cases of cyst type (with plaque-like, papillary, or mural nodule vegetations), two cases of cystic-solid mixed type
(with thickened septum or wall), and four cases of solid type. 3. DWI diffusion was limited, and ADC was reduced on all solid components
(vegetation, septa, and cyst wall). 4. The solid parts were significantly enhanced on T1-enhanced MRI. 5. There was no metastasis in the pelvic
cavity, and a few ascites (negative tumor cells) in three patients.

Conclusions:
MRI characteristics of stage IA ovarian carcinomas were large tumors; cystic, cystic-solid, or solid; solid parts limited diffusion on DWI and low
ADC; enhancement of the cyst wall, vegetation, and septa; no pelvic metastasis.
Lipid Nanocarriers as an Alternative for the Delivery of Bioactive
Compounds Beneficial to Health
Authors: da Costa de Quadros Camila , de Sousa Araujo Alan Carvalho , Latorres Juliana Machado , Michelon Mariano , de las Mercedes Salas-Mellado Myriam 
Published: March 2023

Abstract:
Bioactive compounds derived from food or plants have become a natural source with
the potential for producing functional, nutraceutical, and pharmaceutical foods due to their biological
functions and beneficial health effects. However, to perform such physiological processes,
these compounds need to be absorbed through the gastrointestinal tract. Among the existing technologies,
nanoencapsulation increases physical stability, protection, and the contact surface, facilitating
the solubility and bioavailability of such compounds. In this type of encapsulation, lipid
nanocarriers are promising carriers due to their lipid structure and containing hydrophilic surfactant,
capable of facilitating the intestinal absorption of active compounds. However, in food or
drugs, one of the significant challenges for applying bioactive compounds on a nanoscale is the
lack of in vivo studies that establish safety limits for cytotoxicity. This review covered recent
studies on the encapsulation of natural bioactive compounds in different types of lipid nanocarriers.
In addition to methods for obtaining and characterizing nanocarriers, bioactivities with beneficial
potential for human health, such as antioxidant, antimicrobial, antihypertensive, antidiabetic,
and neuroprotective, are mentioned. The manuscript deals with the bioaccessibility of active compounds,
new perspectives, and challenges for applying lipid nanocarriers.
CUBOSOME-A Novel Drug Delivery for Anticancer Drugs
Authors: Dubey Ayush , Chauhan Akash , Kaur Awaneet , Alam Md. Aftab , Yadav Shikha , Rao G.S.N. Koteshewr 
Published: March 2023

Abstract:
This literature study will investigate cubosomal preparation in various pharmaceutical
compositions. Cubosomal particles are nanostructured liquid crystalline particles with submicron
diameters ranging from 10 to 500 nanometers with high encapsulation efficacy. This literature
has investigated the anatomy and function of cubosomal units, as well as their formulation, material
application, benefit, disadvantage, and preparation technique. Due to their nano-irritancy,
cubosomal nanostructures have become a preferred method for treating a range of illnesses.
Cutaneous Adverse Drug Reactions: Regional Experience of a Global Challenge
Authors: Bushehri Behzad , Mokhtarpoor Akbar , Bahrami Ehsan , Ghorani-Azam Adel 
Published: March 2023

Background:Adverse drug reactions (ADR) are considered any harmful and unintended side effects associated with the use of a drug at the usual therapeutic dose, in which skin is involved in most cases. Therefore, the availability of epidemiological information on reactions, reaction patterns, and their causative drugs can be helpful in timely diagnosis and necessary measures, such as caution in prescribing causative drugs to prevent these types of reactions.Methods:In this retrospective descriptive study, the archived files of patients with dermatoses due to ADR referred to Taleghani University Hospital, Urmia, Iran, during 2015-2020 were studied. Patterns and frequency of skin reactions, demographic data, and the frequency of chronic comorbidities were identified.Results:A total of 50 patients with drug-induced skin rash were found, of which 14 were male (28%) and 36 were female (72%). Skin rashes were most frequently found in patients aged 31-40 years. In 76% of patients, there was at least one chronic underlying disease. The most common reaction pattern was maculopapular rash (44%), and the most common causative drugs were antiepileptic drugs (34%) and antibiotics (22%). Mortality was found in 4 cases, which was due to antibiotics and antiepileptic drugs that caused toxic SJS/TEN and erythroderma. The hospital stays were highest in SJS and lowest in a maculopapular rash.Conclusion:Knowledge about the epidemiology and the frequency of adverse drug reactions may be helpful in increasing the awareness of physicians for correct and rational drug prescriptions, which can reduce unnecessary hospital referrals and treatment costs.
Targeting the LINC00324/miR-16-5p/SEPT2 Signaling Cascade is Effective to Reverse Malignant Phenotypes in Glioblastoma
Authors: Chen Bo , Lin Pengzhen , Li Nan 
Published: March 2023

Background:Long non-coding RNAs (LncRNAs) are identified as pivotal regulators and biomarkers for glioblastoma (GBM). However, the role of a novel LncRNA LINC00324 in regulating GBM progression has not been fully studied in the existing publications.Objective:In this study, we evidenced LINC00324 to act as an oncogene to facilitate GBM development, and the underlying mechanisms have also been uncoveredMethods:Clinicopathology and follow-up data of GBM patients were retrospectively studied, LINC00324 expression in clinical tissue or cell lines of GBM was measured by Real-time qPCR, and the role of LINC00324 in cell proliferation and migration was investigated by loss-of-function experiments in vitro and in vivo. The targeting genes of LINC00324 were predicted and verified by bioinformatic analysis and dual luciferase reporter gene system, respectively.Results:LINC00324 was found to be significantly upregulated in GBM tissues and cells in contrast to normal counterparts, and the GBM patients with high-expressed LINC00324 tended to have a worse prognosis. Further, loss-offunction experiments showed that the silencing of LINC00324 suppressed cell proliferation, colony formation and migration, and promoted cell apoptosis in GBM cells in vitro. Consistently, the in vivo experiments supported that LINC00324 ablation also restrained tumorigenesis in nude mice models. The following mechanism studies showed that LINC00324 sponged miR-16-5p to upregulate SEPT2 in a competing endogenous RNA-dependent manner, and the inhibitory effects of LINC00324 downregulation on the malignant characteristics of GBM cells were abrogated by both miR-16-5p ablation and SEPT2 overexpression.Conclusion:LINC00324 promotes the malignant phenotypes in GBM via targeting the miR-16-5p/SEPT2 axis, and the study provides novel biomarkers for GBM diagnosis and therapy
APOE4 is a Risk Factor and Potential Therapeutic Target for Alzheimer's Disease
Authors: Ayyubova Gunel 
Published: March 2023

Abstract:
Alzheimer's disease (AD) is a progressive neurodegenerative disease, the main pathological
hallmark of which is the loss of neurons, resulting in cognitive and memory impairments. Sporadic
late-onset AD is a prevalent form of the disease and the apolipoprotein E4 (APOE4) genotype is the
strongest predictor of the disease development. The structural variations of APOE isoforms affect their
roles in synaptic maintenance, lipid trafficking, energy metabolism, inflammatory response, and BBB
integrity. In the context of AD, APOE isoforms variously control the key pathological elements of
the disease, including Aβ plaque formation, tau aggregation, and neuroinflammation. Taking into
consideration the limited number of therapy choices that can alleviate symptoms and have little impact
on the AD etiology and progression to date, the precise research strategies guided by apolipoprotein E
(APOE) polymorphisms are required to assess the potential risk of age-related cognitive decline
in people carrying APOE4 genotype. In this review, we summarize the evidence implicating the
significance of APOE isoforms on brain functions in health and pathology with the aim to identify the
possible targets that should be addressed to prevent AD manifestation in individuals with the APOE4
genotype and to explore proper treatment strategies.
Comprehensive Perspective Towards the Management of Proteinopathies
by Elucidating Protein Misfolding and Aggregation
Authors: Ahanger Ishfaq Ahmad , Ashraf Ghulam Md. , Sharma Anurag , Islam Asimul 
Published: March 2023

Abstract:
Protein misfolding and aggregation is the phenomenon of the generic propensity of proteins,
considered as a dark side of the protein world, and its exact mechanism is still not deciphered.
Understanding the complexity of protein aggregation is currently the primary apprehension and challenge
in biology and medicine due to their association with various debilitating human proteinopathies
and neurodegenerative diseases. The mechanism of protein aggregation, associated diseases, and the
development of efficient therapeutic strategies against these diseases are very challenging. These diseases
are caused by different proteins, each protein with different mechanisms and consisting of various
microscopic phases or events. These microscopic steps are functioning on different timescales during
aggregation. Here, we highlighted the different features and current trends in protein aggregation.
The study thoroughly recapitulates the various factors influencing, possible causes, types of aggregates
and aggregation, their different proposed mechanisms, and the methods used to study the aggregation.
Additionally, the formation and elimination of misfolded or aggregated proteins in the cell, the role of
the ruggedness of the protein folding landscape in protein aggregation, proteinopathies, and the challenges
for their prevention are comprehensively elucidated. A holistic understanding of different aspects
of aggregation, molecular steps governing the various features of protein quality control, and
crucial queries about the modulation of these processes and their interactions with other systems in
cellular protein quality control can be considered conducive to comprehending the mechanism, designing
effective approaches towards prevention of protein aggregation, rationalizing the etiology and development
of novel strategies against therapy and management of the proteinopathies.
Recent Patents on Pitching Machine
Authors: Yao Lan , Xiang Chao-Fang , Yu Jia-Wei , Jiang Yu-Peng 
Published: March 2023

Abstract:
With the improvement of living standards and the acceleration of the pace of modern life,
people pay more and more attention to health. All kinds of ball games are deeply loved by people.
Most people like to go to all kinds of equipment halls for all kinds of sports. However, at present,
there are few types of service machines, and there is still a lot of room for development. With the
development of ball games, small simple serve machine, as important equipment for modern entertainment
and sports, has research projects in various countries and occupies a large market share.
The purpose of this study is to synthesize the existing pitching mechanism, summarize and analyze
the advantages and disadvantages of various pitching mechanisms from a large number of documents
and patents, and solve some problems with the existing pitching machine. This paper summarizes
various patents and the latest research progress on ball-pitching machines. From the mechanical
structure of the pitching machine to the functions it can realize, the advantages and disadvantages
of the serving machine are analyzed. By summarizing the characteristics of a large number
of pitching mechanisms, this paper analyzes some problems existing in the pitching machine and
looks forward to the research and design of the pitching machine. Combined with relevant mechanical
technology, this paper refers to the patents related to various ball automatic mechanical pitching
devices and draws valuable conclusions through the summary and comparison of these patents.

Methods:
This paper summarizes various patents and the latest research progress on ball-pitching machines. From the mechanical structure of the pitching machine to the functions it can realize, the advantages and disadvantages of the serving machine are analyzed.
Digital Intervention Barriers Scale–7 (DIBS-7): Development, Evaluation, and Preliminary Validation
Authors: Ramos Giovanni , Montoya Amanda Kay , Hammons Hayley Renee , Smith Danielle , Chavira Denise April , Rith-Najarian Leslie Rose 
Published: March 2023

Background
The translation of mental health services into digital formats, deemed digital mental health interventions (DMHIs), has the potential to address long-standing obstacles to accessing care. However, DMHIs have barriers of their own that impact enrollment, adherence, and attrition in these programs. Unlike in traditional face-to-face therapy, there is a paucity of standardized and validated measures of barriers in DMHIs.

Objective
In this study, we describe the preliminary development and evaluation of such a scale, the Digital Intervention Barriers Scale-7 (DIBS-7).

Methods
Following an iterative QUAN → QUAL mixed methods approach, item generation was guided by qualitative analysis of feedback from participants (n=259) who completed a DMHI trial for anxiety and depression and identified barriers related to self-motivation, ease of use, acceptability, and comprehension of tasks. Item refinement was achieved through DMHI expert review. A final item pool was administered to 559 treatment completers (mean age 23.02 years; 438/559, 78.4% female; 374/559, 69.9% racially or ethnically minoritized). Exploratory factor analyses and confirmatory factor analyses were estimated to determine the psychometric properties of the measure. Finally, criterion-related validity was examined by estimating partial correlations between the DIBS-7 mean score and constructs related to treatment engagement in DMHIs.

Results
Statistical analyses estimated a 7-item unidimensional scale with high internal consistency (α=.82, ω=0.89). Preliminary criterion-related validity was supported by significant partial correlations between the DIBS-7 mean score and treatment expectations (pr=–0.25), number of modules with activity (pr=–0.55), number of weekly check-ins (pr=–0.28), and treatment satisfaction (pr=–0.71).

Conclusions
Overall, these results provide preliminary support for the use of the DIBS-7 as a potentially useful short scale for clinicians and researchers interested in measuring an important variable often associated with treatment adherence and outcomes in DMHIs.
Mediating Role of Treatment Perceptions in the Relationship Between Individual Characteristics and Engagement With a Digital Psychological Intervention for Pediatric Chronic Pain: Secondary Data Analysis
Authors: de la Vega Rocio , Palermo Tonya M 
Published: March 2023

Background
Engagement predicts benefits from self-managed treatments. However, engagement is an important concern in digital interventions, with over 50% of patients being nonadherent to interventions in chronic conditions such as chronic pain. Little is known about the individual characteristics that contribute to engagement with a digital self-management treatment.

Objective
This study tested the mediating role of treatment perceptions (difficulty and helpfulness) in the association between individual baseline characteristics (treatment expectancies and readiness to change) and treatment engagement (online and offline) with a digital psychological intervention for adolescents with chronic pain.

Methods
A secondary data analysis of a single-arm trial of Web-based Management of Adolescent Pain, a self-guided internet intervention developed for the management of chronic pain in adolescents, was conducted. Survey data were collected at baseline (T1), midtreatment (ie, 4 weeks after the treatment started; T2), and post treatment (T3). Online engagement was assessed using back-end information on the number of days adolescents accessed the treatment website, while the offline engagement was assessed with the reported frequency of use of skills (ie, pain management strategies) learned at the end of the treatment. Four parallel multiple mediator linear regression models, using ordinary least square regression incorporating the variables were tested.

Results
In total, 85 adolescents with chronic pain (12-17 years old, 77% female) participated. Several mediation models were significant in predicting online engagement. A significant indirect effect was found for the path expectancies–helpfulness–online engagement (effect 0.125; SE 0.098; 95% CI 0.013-0.389) and for the path precontemplation–helpfulness–online engagement (effect −1.027; SE 0.650; 95% CI −2.518 to −0.054). Fourteen percent of the variance of online engagement was explained by the model including expectancies as a predictor (F3=3.521; P<.05), whereas 15% was explained by the model where readiness to change was the predictor (F3=3.934; P<.05). Offline engagement was partially explained in the model including readiness to change as the predictor but with marginal significance (F3=2.719; R2=0.111; P=.05).

Conclusions
Treatment perception, specifically, perceived helpfulness, was a mediator of the pathway between both treatment expectancies and readiness to change and online engagement with a digital psychological intervention for chronic pain. Assessing these variables at baseline and midtreatment may help to determine the risk of nonadherence. Further work is needed to confirm these mediation pathways in larger samples.

Trial Registration
ClinicalTrials.gov NCT04043962; https://clinicaltrials.gov/ct2/show/NCT04043962
Step Count, Self-reported Physical Activity, and Predicted 5-Year Risk of Atrial Fibrillation: Cross-sectional Analysis
Authors: Shapira-Daniels Ayelet , Kornej Jelena , Spartano Nicole L , Wang Xuzhi , Zhang Yuankai , Pathiravasan Chathurangi H , Liu Chunyu , Trinquart Ludovic , Borrelli Belinda , McManus David D , Murabito Joanne M , Benjamin Emelia J , Lin Honghuang 
Published: March 2023

Background
Physical inactivity is a known risk factor for atrial fibrillation (AF). Wearable devices, such as smartwatches, present an opportunity to investigate the relation between daily step count and AF risk.

Objective
The objective of this study was to investigate the association between daily step count and the predicted 5-year risk of AF.

Methods
Participants from the electronic Framingham Heart Study used an Apple smartwatch. Individuals with diagnosed AF were excluded. Daily step count, watch wear time (hours and days), and self-reported physical activity data were collected. Individuals’ 5-year risk of AF was estimated, using the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE)–AF score. The relation between daily step count and predicted 5-year AF risk was examined via linear regression, adjusting for age, sex, and wear time. Secondary analyses examined effect modification by sex and obesity (BMI≥30 kg/m2), as well as the relation between self-reported physical activity and predicted 5-year AF risk.

Results
We examined 923 electronic Framingham Heart Study participants (age: mean 53, SD 9 years; female: n=563, 61%) who had a median daily step count of 7227 (IQR 5699-8970). Most participants (n=823, 89.2%) had a <2.5% CHARGE-AF risk. Every 1000 steps were associated with a 0.08% lower CHARGE-AF risk (P<.001). A stronger association was observed in men and individuals with obesity. In contrast, self-reported physical activity was not associated with CHARGE-AF risk.

Conclusions
Higher daily step counts were associated with a lower predicted 5-year risk of AF, and this relation was stronger in men and participants with obesity. The utility of a wearable daily step counter for AF risk reduction merits further investigation.
Validation of the Attitudes Towards Psychological Online Interventions Questionnaire Among Black Americans: Cross-cultural Confirmatory Factor Analysis
Authors: Ellis Donovan Michael , Anderson Page Lyn 
Published: March 2023

Background
Acceptability of digital mental health interventions is a significant predictor of treatment-seeking behavior and engagement. However, acceptability has been conceptualized and operationalized in various ways, which decreases measurement precision and leads to heterogeneous conclusions about acceptability. Standardized self-report measures of acceptability have been developed, which have the potential to ameliorate these problems, but none have demonstrated evidence for validation among Black communities, which limits our understanding of attitudes toward these interventions among racially minoritized groups with well-documented barriers to mental health treatment.

Objective
This study aims to examine the psychometric validity and reliability of one of the first and most widely used measures of acceptability, the Attitudes Towards Psychological Online Interventions Questionnaire, among a Black American sample.

Methods
Participants (N=254) were recruited from a large southeastern university and the surrounding metropolitan area and completed the self-report measure via a web-based survey. A confirmatory factor analysis using mean and variance adjusted weighted least squares estimation was conducted to examine the validity of the underlying hierarchical 4-factor structure proposed by the original authors of the scale. An alternative, hierarchical 2-factor structure model and bifactor model were examined for comparative fit.

Results
The findings indicated that the bifactor model demonstrated a superior fit (comparative fit index=0.96, Tucker-Lewis index=0.94, standardized root mean squared residual=0.03, and root mean square error of approximation=0.09) compared with both 2- and 4-factor hierarchical structure models.

Conclusions
The findings suggest that, within a Black American sample, there may be greater utility in interpreting the Attitudes Towards Psychological Online Interventions Questionnaire subscales as attitudinal constructs that are distinct from the global acceptability factor. The theoretical and practical implications for culturally responsive measurements were explored.