bluuebunny/crossref_metadata_2025_split huggingface dataset:
Current Real‐World Status of Off‐Label Under‐ and Over‐Dose of Direct Oral Anticoagulants After Atrial Fibrillation Ablation
Authors: Kino Tabito , Nogami Akihiko , Soejima Kyoko , Uno Kikuya , Kumagai Koichiro , Kurita Takashi , Fukuzawa Masayuki , Takita Atsushi , Ishizu Tomoko , Aonuma Kazutaka ,   and other members of the RYOUMA Registry Investigators
Published: January 2025

ABSTRACTBackgroundOff‐label under‐ and overdosing of direct oral anticoagulants (DOACs) in patients with atrial fibrillation (AF) is not uncommon in real‐world practice.ObjectiveThis study aimed to identify efficacy and safety of off‐label DOACs dose after AF ablation.MethodsThe RYOUMA registry was a prospective multicenter study of Japanese patients who underwent AF ablation between 2017 and 2018. DOAC prescriptions were categorized into on‐label standard dose, on‐label reduced dose, off‐label underdose, and off‐label overdose.ResultsThe proportion of off‐label doses among patients after AF ablation varied depending on the type of DOAC, ranging from 13.5% to 34.9%. Of 2821 patients, 366 (13.0%) were prescribed an off‐label underdose and exhibited significantly higher CHADS2, CHA2DS2‐VASc, CHA2DS2‐VA, HELT‐E2S2, and HAS‐BLED scores, age, concomitant use of antiplatelets, and lower weight when compared to the on‐label standard dose (n = 1809). While the incidence of ischemic stroke after 1 year of off‐label underdose was notably low (0.28%), the rate of major bleeding was relatively high (1.7%). Off‐label overdose was prescribed to 134 patients (4.8%), who showed a significantly higher incidence of major bleeding (3.0%) compared to on‐label standard dose (0.91%; p = 0.02). The off‐label overdose group did not have any particular background and its thromboembolic risk was, conversely, low. The most likely cause of off‐label overdose was clinicians potentially overlooking dose criteria, including advanced age, low body weight, and low creatinine clearance.ConclusionsIn patients after AF ablation, off‐label DOAC overdose was infrequent, but significantly associated with higher incidence of major bleeding during the remote period after AF ablation.Trial RegistrationThe study was registered as UMIN000026092 (University Hospital Medical Information Network‐Clinical Trial Registry).
Application of midnight‐noon ebb‐flow combined with five‐element music therapy in continuous nursing of patients with chronic wounds
Authors: Li Yaru , Wang Meng , Shi Zhigang , Wang Xiyu , Niu Yaojie 
Published: January 2025

AbstractBackgroundTo investigate the effect of Midnight‐noon Ebb‐flow combined with five‐element music therapy in the continuous nursing of patients with chronic wounds.MethodsFrom March 2022 to November 2023, we recruited 50 eligible chronic wound patients and randomly divided them into two groups according to a random number table: the experimental group (n = 25) and the control group (n = 25). The control group was treated with conventional nursing measures. The experimental group received Midnight non Ebb flow Combined with Five element Music Therapy on the basis of the control group.ResultsThe Self Rating Anxiety Scale (SAS) of the experimental group (39.71 ± 4.30 points vs. 50.29 ± 3.54 points, t = 4.927，p < 0.001)、The Self Rating Depression Scale (SDS) (42.09 ± 6.23 points vs. 53.98 ± 3.50 points, t = 5.381，p < 0.001)、 The total score of the Pressure Ulcer Healing Scale (PUSH) (2.12 ± 3.71 points vs. 4.80 ± 3.76 points, t = 2.535, p = 0.015) was lower than that of the control group; The total score of the 36 item Short Form Health Survey (SF‐36) (102.88 ± 5.88 vs 92.48 ± 6.99 points, t = −5.692, p < 0.001) was higher than that of the control group; Comparing the VAS scores of two groups of patients on days 1, 3, and 7, it was found that the control group was higher than the observation group at all three time points; Secondly, the effective rate of wound healing in the experimental group was higher than that in the control group (92% vs 68%, x2 = 4.500, p = 0.034).ConclusionMidnight‐noon Ebb‐flow combined with five‐element music therapy is a nursing intervention program with considerable benefits for the treatment of chronic wounds, such as effective progress in wound health outcomes, alleviation of patients’ anxiety, depression, and pain symptoms, and consequently improvement in quality of life.
Stigma, Depression, and Attitudes Towards Seeking Psychological Help Among Nurses: The Role of Personal Stigma as an Inconsistent Mediator
Authors: Özel Erçel Nihan , Altundal Duru Hilal , Temel Gülhan , Yılmaz Mualla , Çolak Cemil 
Published: January 2025

ABSTRACTRationaleIdentifying whether perceived stigma or personal stigma more significantly affects nurses' attitudes towards seeking psychological help is essential for effectively addressing current challenges and facilitating early intervention for the well‐being of nurses and their patients.Aims and ObjectivesThe aim of this study was to explore the mediating roles of personal stigma and depression in the relationship between perceived stigma among nurses and their attitudes towards seeking psychological help.MethodsThe sample of this descriptive cross‐sectional study consisted of 302 nurses working in a university hospital in southern Turkey, selected using the purposive sampling method, between April 1 and May 1, 2021. Data collection tools were Personal Information Form, Attitudes Towards Seeking Psychological Help Scale‐Short Form, Depression Stigma Scale, and Beck Depression Inventory. The data were analyzed using SPSS version 26.0. Correlation and regression analyzes were used to examine the relationships between attitudes towards seeking psychological help, personal stigma, perceived stigma, and Beck depression levels. Mann–Whitney U and Kruskal–Wallis tests were employed to compare scale scores across socio‐demographic variables. The mediation models were tested with variables such as perceived stigma, personal stigma, and Beck depression levels as mediators. Results were presented with 95% confidence intervals, and significance was set at p < 0.05.ResultsAttitudes towards seeking psychological help were negatively influenced by nurses' stigma levels, especially, by personal stigma levels. Additionally, nurses' attitudes were positively influenced by their unit of work and the presence of a chronic illness, while being male and experiencing higher levels of personal stigma had a negative impact. No significant relationships were found between perceived stigma, personal stigma, and depression levels.ConclusionHigh levels of personal stigma negatively affect attitudes towards seeking psychological help; however, when considered alongside working in oncology and having a chronic illness, the impact of personal stigma becomes positive. Future research should delve deeper into these dynamics to develop targeted strategies for reducing personal stigma and enhancing help‐seeking behaviors among nurses. Interventions are necessary to foster positive help‐seeking attitudes among nurses and reduce stigma. Aligned with the findings of this study, training and awareness initiatives aimed at improving mental health literacy among nurses can play a pivotal role in reducing stigma and encouraging proactive use of mental health resources.
Regional Dependencies and Local Spillovers: Insights From Commuter Flows
Authors: Krause Melanie , Kripfganz Sebastian 
Published: January 2025

ABSTRACTA region's growth trajectory is influenced by the economic circumstances of other regions in its proximity. While proximity is often understood in a geographic sense, economic connectivity can take many different forms. In particular, shock transmission processes between regions are inherently asymmetric and heterogeneous, which is not captured by geographic proximity measures. As a potential channel for economic dependencies, we consider cross‐regional commuter flows. Commuters, who spend a substantial portion of their income in a different place from where they earn it, connect peripheral regions to economic centers. In an econometric framework, we estimate time‐space dynamic panel models with German county‐level data. Given those estimates, we demonstrate a considerable variation in the spatial distribution of shock responses from using alternative proxies for spatial dependency, which is hidden by the traditional focus on average marginal effects. Local spatial multipliers differ depending on the nature and origin of the shock and the assumed network structure.
Antagonistic Potential of Different Species of Trichoderma Against Sclerotinia sclerotiorum
Authors: Fagundes‐Nacarath Inaia Rhavene , Cavalcante Gilcianny Pignata , Brito Renata Aparecida Santos , Costa Paulo Mafra Almeida , Debona Daniel , Maffia Luiz Antonio , Rodrigues Fabrício Ávila 
Published: January 2025

ABSTRACTThe fungus Trichoderma spp., commonly isolated from soil, rhizosphere, and as an endophyte in different plant tissues, displays greater antagonistic potential against different types of pathogens. This study aimed to select isolates of Trichoderma spp. from common bean and soybean fields in Minas Gerais State, Brazil, to evaluate their antagonism against Sclerotinia sclerotiorum. Forty‐eight isolates of Trichoderma spp. (30 rhizospheric, 11 epiphytic, four endophytic, and three from crop debris) were used in this study. Based on the sequencing of ITS, TEF1‐α, and RPB2 regions, these isolates were classified in eight species of Trichoderma as follows: T. harzianum (29 isolates), T. koningiopsis (five isolates), T. hamatum (four isolates), T. atroviride (four isolates), T. asperelloides (two isolates), T. longibrachiatum (two isolates), T. asperellum (one isolate), and T. neokoningii (one isolate). Eight isolates completely inhibited mycelial growth of S. sclerotiorum in the pairing culture test in vitro. Twenty‐four isolates displayed the greatest ability to parasitise sclerotia in soil with efficiency ranging from 79% to 99%. In water‐agar medium, 31 isolates inhibited myceliogenic germination of sclerotia from 78% to 100%, while seven isolates inhibited the carpogenic germination of sclerotia by more than 85%. Eight isolates affected the colonisation of detached leaflets of common bean and soybean plants by hyphae of S. sclerotiorum. The isolates UN34 and IM2 of T. harzianum were the most promising. The isolate UN34 reduced fungal survival and both myceliogenic and carpogenic germinations of sclerotia, while the colonisation of leaflets and stems of common bean and soybean plants by S. sclerotiorum was greatly lower by the IM2 isolate. In conclusion, the isolates of Trichoderma spp. obtained in this study displayed great potential for use for the biocontrol of S. sclerotiorum.
Unveiling coping mechanisms in marketplace discrimination: The allure of artificial intelligence recommendations
Authors: Talebi Arash , Mukherjee Sourjo , Gera Nazia , Kaur Kulwinder , Das Gopal 
Published: January 2025

AbstractDespite artificial intelligence's (AI) increased efficiency and accuracy in many contexts, algorithm aversion, that is, people's biased preference for human recommendations over those of algorithms, is a well‐documented phenomenon. In this research, we show a reversal of the algorithm aversion phenomenon, referred to as algorithm appreciation, in the prevalent context of marketplace discrimination. Specifically, the current research documents people's increased propensity to rely on AI‐based recommendations over those proposed by human counterparts in the aftermath of marketplace discrimination. Such an increased preference happens because it serves as a coping strategy for consumers who have faced discrimination in the marketplace from other human actors. The results of a series of three lab studies and one field study provide consistent support for the proposed effect and document the underlying psychological mechanism driving this effect through perceived embarrassment. Using a moderated‐mediation model, we identify a boundary condition of the effect by demonstrating that the focal effect, that is, algorithm appreciation, remains valid under public consumption but diminishes under private consumption. Employing the natural setting of the field, we replicate our findings with actual consumers making real choices. Our findings have important implications (e.g., integrating AI‐driven recommendation systems into firms' platforms in sectors susceptible to marketplace discrimination and developing ethical guidelines for AI systems) for managers and companies.
Enhancing Meat Analog Texture Using Wet‐Spun Fibroin Protein Fibers: A Novel Approach to Mimic Whole‐Muscle Meat
Authors: Chuang Rita , Naidu Arin , Galipon Josephine 
Published: January 2025

ABSTRACTThe increasing demand for protein‐rich, plant‐based foods has driven the development of meat analogs that closely mimic the texture and mouthfeel of animal meat. While plant‐based fibrils and electrospun silk fibroin fibers have been explored for texture enhancement and scaffolding in both meat analogs and cell‐based meats, the use of wet‐spun fibroin protein fibers as a food ingredient remains underexplored. This study investigates the potential of wet‐spun recombinant fibroin fibers to enhance the textural properties of meat analogs. Short fibers, with varying tensile strengths and diameters, were incorporated into a commercial ground pork analog to create improved patty samples. The results showed that adding hydrophilic, 30 μm‐diameter, 3‐mm short protein fibers at 1% (w/w) significantly increased the springiness of the pork analog by 45%. Additionally, fiber sheets designed to mimic the endomysium structure of intramuscular connective tissue were integrated into the minced pork analog using a three‐dimensional needle punching technique. This approach successfully recreated the interlacing endomysium structure found in whole‐muscle pork, yielding a texture that closely matched the slice shear force, springiness, and cohesiveness of traditional pork. In conclusion, the incorporation of wet‐spun protein fibers offers a promising strategy to enhance the textural qualities of meat analogs, making them more comparable to animal meat and potentially more appealing to consumers seeking high‐quality plant‐based alternatives.
Textural Analysis of Sea Lamprey Muscle From Guadiana and Mondego Rivers (Portugal) Using the Warner‐Bratzler Shear Method
Authors: Agulheiro‐Santos Ana Cristina , Machado Graça , Eusébio Teresa , Lança Maria João 
Published: January 2025

ABSTRACTAssessment of sea lamprey texture from the Guadiana and Mondego River basins. Lamprey has served as food for centuries, and nowadays it is highly appreciated, mainly in southern European countries. Therefore, the quality requirements of the lamprey are closely scrutinized by consumers. The texture is commonly referred to as tenderness, and is one crucial sensory attribute valued by consumers. A deep search for scientific publications about texture evaluation of lamprey allows us to conclude that there is no work published. So, a wide review was carried out on methods for evaluating fish texture. This study aims: (i) to assess the texture of specimens caught in two Portuguese rivers, Guadiana, and Mondego and (ii) to validate the Warner‐Bratzler shear method for assessing sea lamprey's texture. Our results on texture of sea lampreys caught in Guadiana and Mondego River basins revealed significant differences in texture parameters, obtained through the Warner Bratzler test. Sea lamprey from Guadiana River basin exhibited lower values of firmness (123.15 N) and energy indicating softer flesh, and lampreys from Mondego River basin displayed higher firmness values (147.37 N), indicating harder flesh. This study confirmed the adequacy of the Warner‐Bratzler shear method for assessing sea lamprey texture due to its sensitivity and accuracy in measuring the texture parameters obtained through force deformation curve. This knowledge will allow future studies to use a consistent method to assess texture. The certification of regional food products increases fishing communities' income and gives consumers greater confidence in the quality of these delicatessen products.
Efficacy and Safety of Silodosin for the Treatment of Female LUTS: A 12‐Week Prospective, Single‐Center Study
Authors: Wee Chung Beum , Kim Tae‐Hyoung , Tae Jong Hyun , Choi Se Young 
Published: January 2025

ABSTRACTObjectivesThis study aimed to evaluate the clinical efficacy and safety of silodosin in female patients with lower urinary tract symptoms (LUTSs), addressing the limited evidence supporting alpha‐blocker use in this population.MethodsA 12‐week, single‐arm, prospective, open‐label study was conducted from May 2021 to January 2023. Female patients aged over 18 with an International Prostate Symptom Score (IPSS) ≥ 8 were enrolled and treated with silodosin (8 mg once daily). Primary endpoints included changes in IPSS from baseline to 12 weeks. Secondary endpoints assessed IPSS quality of life (QOL), Overactive Bladder Symptom Score (OABSS), maximal urinary flow rate (Q max), and residual urine (RU).ResultsNinety‐five patients were enrolled, with 85 included in the analysis. After 12 weeks, the mean total IPSS significantly decreased from 18.65 ± 6.89 at baseline to 12.54 ± 5.28 (p < 0.001). IPSS‐QOL improved from 4.14 ± 1.01 to 3.12 ± 0.79 (p < 0.001). OABSS decreased from 6.89 ± 3.41 to 4.28 ± 2.39 (p < 0.001), and RU reduced from 51.39 ± 55.38 to 29.95 ± 29.83 mL (p < 0.001). Q max increased from 13.96 ± 6.74 to 16.48 ± 6.09 mL/s (p < 0.001), while voiding volume increased from 163.02 ± 70.53 to 176.12 ± 47.16 mL (p = 0.026). Silodosin was well tolerated, with no serious adverse events noted.ConclusionsSilodosin demonstrates efficacy and safety in treating female patients with moderate‐to‐severe LUTS, suggesting that it can be considered a viable treatment option alongside established therapies. Further studies are warranted to confirm these findings.
Climate Change Drives Changes in the Size and Composition of Fungal Communities Along the Soil–Seedling Continuum of Schima superba
Authors: Wu Xian , MacKenzie M. Derek , Yang Jiarong , Lan Guoyu , Liu Yu 
Published: January 2025

ABSTRACTPlant microbiomes have a major influence on forest structure and functions, as well as tree fitness and evolution. However, a comprehensive understanding of variations in fungi along the soil–plant continuum, particularly within tree seedlings, under global warming is lacking. Here, we investigated the dynamics of fungal communities across different compartments (including bulk soil and rhizosphere soil) and plant organs (including the endosphere of roots, stems and leaves) of Schima superba seedlings exposed to experimental warming and drought using AccuITS absolute quantitative sequencing. Our results revealed that warming and drought significantly reduced the number of specific fungal amplicon sequence variants (ASVs) in the bulk soil and rhizosphere soil, respectively. Variations in fungal communities were mainly explained by compartments and plant organs, with the composition of endophytic fungal communities within leaves (primarily attributed to species gain or loss) being most influenced by climate change. Moreover, warming significantly reduced the migration of Ascomycota, soil saprotrophs, wood saprotrophs and yeasts from the bulk soil to the rhizosphere soil but increased that of plant pathogens from the roots to the stems. Drought significantly decreased the absolute abundances of Chytridiomycota, Glomeromycota and Rozellomycota, as well as the migration of ectomycorrhizal fungi from the bulk soil to the rhizosphere soil but increased that of plant pathogens. Warming could indirectly reduce leaf area by increasing the diversity of leaf pathogens. These findings have potential implications for enhancing the resilience and functioning of natural forest ecosystems under climate change through the manipulation of plant microbiomes, as demonstrated in agroecosystems.
Deceptive air: Unravelling pseudo‐peritonitis in peritoneal dialysis patients—A diagnostic challenge
Authors: Wipattanakitcharoen Aschariya , Towannang Piyaporn , Lumlertgul Nuttha , Townamchai Natavudh , Kanjanabuch Talerngsak 
Published: January 2025

AbstractPneumoperitoneum, or free air in the peritoneal cavity, typically indicates visceral organ perforation requiring urgent surgical intervention. In peritoneal dialysis (PD) patients, however, it can occur without prior surgery or trauma, often due to technical errors, and may mimic peritonitis, risking misdiagnosis and unnecessary treatment. We report a case of a 73‐year‐old male PD patient presenting with fever, abdominal pain, and bowel ileus, initially raising concerns for organ perforation due to pneumoperitoneum. A comprehensive diagnostic workup and history taking, including molecular testing, excluded infections and chemical causes such as icodextrin, drugs, bile, faeces, blood, and malignancy. The cause was traced to improper PD technique, specifically a lapse in the ‘flush‐before‐fill’ method. Conservative management and retraining led to full symptom resolution and disappearance of the free air. This case highlights the importance of thorough diagnostic evaluations to rule out serious causes of pneumoperitoneum in PD patients, emphasizing the role of proper PD technique and patient education in preventing complications. Pneumoperitoneum in PD patients can mimic peritonitis, posing a diagnostic challenge. Comprehensive evaluation and adherence to proper PD practices are essential to avoid unnecessary interventions.
Chronic Kidney Disease Prevalence in India: A Systematic Review and Meta‐Analysis From Community‐Based Representative Evidence Between 2011 to 2023
Authors: Talukdar Rounik , Ajayan Revathy , Gupta Shefali , Biswas Sombuddha , Parveen Muneera , Sadhukhan Debobrata , Sinha Anju Pradhan , Parameswaran Sreejith 
Published: January 2025

ABSTRACTChronic kidney disease (CKD) prevalence varies widely across different regions of India. We aimed to identify the status of CKD in India, by systematically reviewing the published community‐based studies between the period of January 2011 to December 2023. PubMed, Scopus, and EMBASE were searched for peer‐reviewed evidence. Records identified for full‐text screening were imported into the Litmaps literature review tool to identify more relevant studies. Two researchers independently examined and retrieved the data. Quality assessment was conducted using the JBI tool for prevalence studies. A random effects model pooled the estimates. Subgroup analysis, meta‐regression and sensitivity analysis explored heterogeneity sources and estimated robustness. Publication bias was assessed with a DOI plot and LFK index. Among the 7062 records identified, 18 studies were included in this review. The pooled prevalence of CKD from community‐based studies in India was 13.24% (confidence intervals (CI) 10.52 to 16.22, I2 99%, p < 0.001). CKD prevalence among men was 14.80%, while among women it was 13.51%. Southern administrative zone had a pooled CKD prevalence of 14.78%. Pooled CKD prevalence was higher in studies from rural areas (15.34%) compared to those from urban areas (10.65%). Significant heterogeneity was found. Subgroup analyses based on sampling strategy, quality score, publication year, and eGFR estimation equation showed no effect on the pooled prevalence. Prediction Intervals confirmed CKD prevalence in India in future studies will fall between 2.64% and 30.17%. This review indicates a rising trend of CKD (from 11.12% during the period 2011 to 2017, to 16.38% between 2018 to 2023) among Indians aged 15 years and above, over the past years. More future regional research is needed to tailor‐make CKD interventions to detect early and manage well.