bluuebunny/crossref_metadata_2025_split huggingface dataset:
Osotua and decolonizing the academe: implications of a Maasai concept
Authors: Wijngaarden Vanessa , Ole Murero Paul Nkoitoi 
Published: April 2023

AbstractIn this paper, an Indigenous elder and non-Indigenous scholar together explore and reflect on attempts to grasp and work academically with the Maasai concept of osotua. We aim to take up this concept not as a piece of data to analyze, but as a partner in theoretical conversations. Osotua describes relationality, in the form of kinship, sharing, symbiosis, and accountability. It aligns and reinforces concepts and approaches of a variety of Indigenous knowledge systems and paradigms, as described by both Indigenous and non-Indigenous scholars. It also has clear parallels with academic theories, for example, in the ontological turn as well as new materialist and post-humanist approaches. Through these cross-fertilizations as well as by its original stance, it may provide novel ideas and practical incentives towards the decolonization of the academe, for example, by enhancing diversity and multi-vocality, while simultaneously inviting incentives to contextualize and reflect on “the self” as part of a dynamic inter-reliant community of academics. Specifically, we focus on the potential theoretical value and resulting practical impact of osotua for decolonizing higher education. A variety of scholars arguing for the decolonization of the academic system has pointed out and criticized the continuities between colonialism and neoliberalism, and outlined how both have influenced a university system where students are graded based on standards informed by specific dominant ontologies and epistemologies; scholars are judged on the number of publications in certain high-ranking journals; and universities are funded based on the quantity of students they “process” within a certain period. How would the perspectives on and dynamics of this system be affected if the symbiotic and nourishing reciprocity of all relationships involved became increasingly visible through the concept of osotua?
The blue wavelengths in laser dentistry: a review of current literature
Authors: Strakas Dimitris , Franzen Rene 
Published: April 2023

AbstractDental laser applications are steadily increasing in popularity amongst dentists for the last four decades. Although many wavelengths are available for practitioners, semiconductor lasers or commonly known as diode lasers, are still the most popular ones. Dental diode laser devices are available in wavelengths that belong to visible and near infrared region of the electromanetic spectrum. Recently, lasers that are in the area of 400–450 nm have emerged in the market and became available to dentists. In this article, we aim to analyze the clinical possibilities we have with these lasers according to the available literature that has been published so far.
Microbial mat compositions and localization patterns explain the virulence of black band disease in corals
Authors: Wada Naohisa , Iguchi Akira , Urabe Yuta , Yoshioka Yuki , Abe Natsumi , Takase Kazuki , Hayashi Shuji , Kawanabe Saeko , Sato Yui , Tang Sen-Lin , Mano Nobuhiro 
Published: April 2023

AbstractBlack band disease (BBD) in corals is characterized by a distinctive, band-like microbial mat, which spreads across the tissues and often kills infected colonies. The microbial mat is dominated by cyanobacteria but also commonly contains sulfide-oxidizing bacteria (SOB), sulfate-reducing bacteria (SRB), and other microbes. The migration rate in BBD varies across different environmental conditions, including temperature, light, and pH. However, whether variations in the migration rates reflect differences in the microbial consortium within the BBD mat remains unknown. Here, we show that the micro-scale surface structure, bacterial composition, and spatial distribution differed across BBD lesions with different migration rates. The migration rate was positively correlated with the relative abundance of potential SOBs belonging toArcobacteraceaelocalized in the middle layer within the mat and negatively correlated with the relative abundance of other potential SOBs belonging toRhodobacteraceae. Our study highlights the microbial composition in BBD as an important determinant of virulence.
The nonlinearity of regulation in biological networks
Authors: Manicka Santosh , Johnson Kathleen , Levin Michael , Murrugarra David 
Published: April 2023

AbstractThe extent to which the components of a biological system are (non)linearly regulated determines how amenable they are to therapy and control. To better understand this property termed “regulatory nonlinearity”, we analyzed a suite of 137 published Boolean network models, containing a variety of complex nonlinear regulatory interactions, using a probabilistic generalization of Boolean logic that George Boole himself had proposed. Leveraging the continuous-nature of this formulation, we used Taylor decomposition to approximate the models with various levels of regulatory nonlinearity. A comparison of the resulting series of approximations of the biological models with appropriate random ensembles revealed that biological regulation tends to be less nonlinear than expected, meaning that higher-order interactions among the regulatory inputs tend to be less pronounced. A further categorical analysis of the biological models revealed that the regulatory nonlinearity of cancer and disease networks could not only be sometimes higher than expected but also be relatively more variable. We show that this variation is caused by differences in the apportioning of information among the various orders of regulatory nonlinearity. Our results suggest that there may have been a weak but discernible selection pressure for biological systems to evolve linear regulation on average, but for certain systems such as cancer, on the other hand, to simultaneously evolve more nonlinear rules.
Multiple intermolecular interactions facilitate rapid evolution of essential genes
Authors: Lai Huei-Yi , Yu Yen-Hsin , Jhou Yu-Ting , Liao Chia-Wei , Leu Jun-Yi 
Published: April 2023

AbstractEssential genes are commonly assumed to function in basic cellular processes and to change slowly. However, it remains unclear whether all essential genes are similarly conserved or if their evolutionary rates can be accelerated by specific factors. To address these questions, we replaced 86 essential genes ofSaccharomyces cerevisiaewith orthologues from four other species that diverged fromS. cerevisiaeabout 50, 100, 270 and 420 Myr ago. We identify a group of fast-evolving genes that often encode subunits of large protein complexes, including anaphase-promoting complex/cyclosome (APC/C). Incompatibility of fast-evolving genes is rescued by simultaneously replacing interacting components, suggesting it is caused by protein co-evolution. Detailed investigation of APC/C further revealed that co-evolution involves not only primary interacting proteins but also secondary ones, suggesting the evolutionary impact of epistasis. Multiple intermolecular interactions in protein complexes may provide a microenvironment facilitating rapid evolution of their subunits.
Phylogenomic analysis uncovers a 9-year variation of Uganda influenza type-A strains from the WHO-recommended vaccines and other Africa strains
Authors: Nabakooza Grace , Owuor D. Collins , de Laurent Zaydah R. , Galiwango Ronald , Owor Nicholas , Kayiwa John T. , Jjingo Daudi , Agoti Charles N. , Nokes D. James , Kateete David P. , Kitayimbwa John M. , Frost Simon D. W. , Lutwama Julius J. 
Published: April 2023

AbstractGenetic characterisation of circulating influenza viruses directs annual vaccine strain selection and mitigation of infection spread. We used next-generation sequencing to locally generate whole genomes from 116 A(H1N1)pdm09 and 118 A(H3N2) positive patient swabs collected across Uganda between 2010 and 2018. We recovered sequences from 92% (215/234) of the swabs, 90% (193/215) of which were whole genomes. The newly-generated sequences were genetically and phylogenetically compared to the WHO-recommended vaccines and other Africa strains sampled since 1994. Uganda strain hemagglutinin (n = 206), neuraminidase (n = 207), and matrix protein (MP, n = 213) sequences had 95.23–99.65%, 95.31–99.79%, and 95.46–100% amino acid similarity to the 2010–2020 season vaccines, respectively, with several mutated hemagglutinin antigenic, receptor binding, and N-linked glycosylation sites. Uganda influenza type-A virus strains sequenced before 2016 clustered uniquely while later strains mixed with other Africa and global strains. We are the first to report novel A(H1N1)pdm09 subclades 6B.1A.3, 6B.1A.5(a,b), and 6B.1A.6 (± T120A) that circulated in Eastern, Western, and Southern Africa in 2017–2019. Africa forms part of the global influenza ecology with high viral genetic diversity, progressive antigenic drift, and local transmissions. For a continent with inadequate health resources and where social distancing is unsustainable, vaccination is the best option. Hence, African stakeholders should prioritise routine genome sequencing and analysis to direct vaccine selection and virus control.
Social contact patterns relevant for infectious disease transmission in Cambodia
Authors: Leung William T. M. , Meeyai Aronrag , Holt Hannah R. , Khieu Borin , Chhay Ty , Seng Sokeyra , Pok Samkol , Chiv Phiny , Drake Tom , Rudge James W. 
Published: April 2023

AbstractSocial mixing patterns are key determinants of infectious disease transmission. Mathematical models parameterised with empirical data from contact pattern surveys have played an important role in understanding epidemic dynamics and informing control strategies, including for SARS-CoV-2. However, there is a paucity of data on social mixing patterns in many settings. We conducted a community-based survey in Cambodia in 2012 to characterise mixing patterns and generate setting-specific contact matrices according to age and urban/rural populations. Data were collected using a diary-based approach from 2016 participants, selected by stratified random sampling. Contact patterns were highly age-assortative, with clear intergenerational mixing between household members. Both home and school were high-intensity contact settings, with 27.7% of contacts occurring at home with non-household members. Social mixing patterns differed between rural and urban residents; rural participants tended to have more intergenerational mixing, and a higher number of contacts outside of home, work or school. Participants had low spatial mobility, with 88% of contacts occurring within 1 km of the participants’ homes. These data broaden the evidence-base on social mixing patterns in low and middle-income countries and Southeast Asia, and highlight within-country heterogeneities which may be important to consider when modelling the dynamics of pathogens transmitted via close contact.
Explanatory predictive model for COVID-19 severity risk employing machine learning, shapley addition, and LIME
Authors: Laatifi Mariam , Douzi Samira , Ezzine Hind , Asry Chadia El , Naya Abdellah , Bouklouze Abdelaziz , Zaid Younes , Naciri Mariam 
Published: April 2023

AbstractThe rapid spread of SARS-CoV-2 threatens global public health and impedes the operation of healthcare systems. Several studies have been conducted to confirm SARS-CoV-2 infection and examine its risk factors. To produce more effective treatment options and vaccines, it is still necessary to investigate biomarkers and immune responses in order to gain a deeper understanding of disease pathophysiology. This study aims to determine how cytokines influence the severity of SARS-CoV-2 infection. We measured the plasma levels of 48 cytokines in the blood of 87 participants in the COVID-19 study. Several Classifiers were trained and evaluated using Machine Learning and Deep Learning to complete missing data, generate synthetic data, and fill in any gaps. To examine the relationship between cytokine storm and COVID-19 severity in patients, the Shapley additive explanation (SHAP) and the LIME (Local Interpretable Model-agnostic Explanations) model were applied. Individuals with severe SARS-CoV-2 infection had elevated plasma levels of VEGF-A, MIP-1b, and IL-17. RANTES and TNF were associated with healthy individuals, whereas IL-27, IL-9, IL-12p40, and MCP-3 were associated with non-Severity. These findings suggest that these cytokines may promote the development of novel preventive and therapeutic pathways for disease management. In this study, the use of artificial intelligence is intended to support clinical diagnoses of patients to determine how each cytokine may be responsible for the severity of COVID-19, which could lead to the identification of several cytokines that could aid in treatment decision-making and vaccine development.
Etiological analysis of patients with sudden sensorineural hearing loss: a prospective case–control study
Authors: Xie Wen , Karpeta Niki , Tong Busheng , Liu Jiali , Peng Haisen , Li Chunhua , Hellstrom Sten , Liu Yuehui , Duan Maoli 
Published: April 2023

AbstractSudden sensorineural hearing loss (SSNHL) is a multifactorial emergency disease. Until now, the etiology of SSNHL is still unknown. Previous studies regarding the etiology of SSNHL are clinical studies depending on clinical data collection and analysis. Due to the insufficient sample size or various selective bias in clinical studies, the results of these studies may be inaccurate. This prospective case–control study aimed at exploring the possible etiology and risk factors of SSNHL. We enrolled 255 SSNHL patients and 255 sex-, age- and residence-matched non-SSNHL subjects in the control group. Our study shows that there was no significant difference in the prevalence of comorbidities including hypertension and diabetes, as well as the incidence of smoking and drinking habits between the case and control groups (P > 0.05). In addition, the peripheral blood white blood cell count, neutrophil count, platelet-to-lymphocyte ratio (PLR) and fibrinogen level of the case group were significantly higher than those in the control group (P < 0.05). These findings suggest smoking, drinking, hypertension and diabetes may not be related to the onset of SSNHL. However, hypercoagulable state and inner ear vascular microthrombosis related to an elevated fibrinogen level might be the risk factors of the disease. In addition, inflammation play an important role of SSNHL onset.Trial Registration: Chinese Clinical Trial Registry. Registration number: ChiCTR2100048991.
Pupil dilation reflects the dynamic integration of audiovisual emotional speech
Authors: Arias Sarah Pablo , Hall Lars , Saitovitch Ana , Aucouturier Jean-Julien , Zilbovicius Monica , Johansson Petter 
Published: April 2023

AbstractEmotional speech perception is a multisensory process. When speaking with an individual we concurrently integrate the information from their voice and face to decode e.g., their feelings, moods, and emotions. However, the physiological reactions—such as the reflexive dilation of the pupil—associated to these processes remain mostly unknown. That is the aim of the current article, to investigate whether pupillary reactions can index the processes underlying the audiovisual integration of emotional signals. To investigate this question, we used an algorithm able to increase or decrease the smiles seen in a person’s face or heard in their voice, while preserving the temporal synchrony between visual and auditory channels. Using this algorithm, we created congruent and incongruent audiovisual smiles, and investigated participants’ gaze and pupillary reactions to manipulated stimuli. We found that pupil reactions can reflect emotional information mismatch in audiovisual speech. In our data, when participants were explicitly asked to extract emotional information from stimuli, the first fixation within emotionally mismatching areas (i.e., the mouth) triggered pupil dilation. These results reveal that pupil dilation can reflect the dynamic integration of audiovisual emotional speech and provide insights on how these reactions are triggered during stimulus perception.
Atypical connectivity aids conversation in autism
Authors: Jasmin Kyle , Martin Alex , Gotts Stephen J. 
Published: April 2023

AbstractIt is well-established that individuals with autism exhibit atypical functional brain connectivity. However, the role this plays in naturalistic social settings has remained unclear. Atypical patterns may reflect core deficits or may instead compensate for deficits and promote adaptive behavior. Distinguishing these possibilities requires measuring the ‘typicality’ of spontaneous behavior and determining how connectivity relates to it. Thirty-nine male participants (19 autism, 20 typically-developed) engaged in 115 spontaneous conversations with an experimenter during fMRI scanning. A classifier algorithm was trained to distinguish participants by diagnosis based on 81 semantic, affective and linguistic dimensions derived from their use of language. The algorithm’s graded likelihood of a participant's group membership (autism vs. typically-developed) was used as a measure of task performance and compared with functional connectivity levels. The algorithm accurately classified participants and its scores correlated with clinician-observed autism signs (ADOS-2). In support of a compensatory role, greater functional connectivity between right inferior frontal cortex and left-hemisphere social communication regions correlated with more typical language behavior, but only for the autism group. We conclude that right inferior frontal functional connectivity increases in autism during communication reflect a neural compensation strategy that can be quantified and tested even without an a priori behavioral standard.
Respiratory brain impulse propagation in focal epilepsy
Authors: Elabasy Ahmed , Suhonen Mia , Rajna Zalan , Hosni Youssef , Kananen Janne , Annunen Johanna , Ansakorpi Hanna , Korhonen Vesa , Seppänen Tapio , Kiviniemi Vesa 
Published: April 2023

AbstractRespiratory brain pulsations pertaining to intra-axial hydrodynamic solute transport are markedly altered in focal epilepsy. We used optical flow analysis of ultra-fast functional magnetic resonance imaging (fMRI) data to investigate the velocity characteristics of respiratory brain impulse propagation in patients with focal epilepsy treated with antiseizure medication (ASM) (medicated patients with focal epilepsy; ME, n = 23), drug-naïve patients with at least one seizure (DN, n = 19) and matched healthy control subjects (HC, n = 75). We detected in the two patient groups (ME and DN) several significant alterations in the respiratory brain pulsation propagation velocity, which showed a bidirectional change dominated by a reduction in speed. Furthermore, the respiratory impulses moved more in reversed or incoherent directions in both patient groups vs. the HC group. The speed reductions and directionality changes occurred in specific phases of the respiratory cycle. In conclusion, irrespective of medication status, both patient groups showed incoherent and slower respiratory brain impulses, which may contribute to epileptic brain pathology by hindering brain hydrodynamics.
Women compared with men work harder for small rewards
Authors: Lewis Carolin A. , Grahlow Melina , Kühnel Anne , Derntl Birgit , Kroemer Nils B. 
Published: April 2023

AbstractIn cost–benefit decision-making, women and men often show different trade-offs. However, surprisingly little is known about sex differences in instrumental tasks, where physical effort is exerted to gain rewards. To this end, we tested 81 individuals (47 women) with an effort allocation task, where participants had to repeatedly press a button to collect food and money tokens. We analyzed the motivational phases of invigoration and effort maintenance with varying reward magnitude, difficulty, and reward type. Whereas women and men did not differ in invigoration, we found that women showed higher effort maintenance as well as higher subjective wanting and exertion ratings for small rewards compared with men. Notably, men increased their effort more than women for higher rewards to match women’s levels of performance. Crucially, we found no sex differences depending on reward type or difficulty, indicating that sex differences were specific to the encoding of the magnitude of benefits, not costs. To summarize, women exerted higher physical effort for small rewards, which corresponded with an elevated subjective value in women compared with men. Therefore, sex differences in perceived reward magnitude may contribute to differential behavioral preferences highlighting the potential of cost–benefit decision-making to provide insights about potential mechanisms.
Health trajectories of elderly living in French senior housing: a longitudinal perspective
Authors: Boucaud-Maitre Denis , Meillon Céline , Letenneur Luc , Villeneuve Roxane , Dartigues Jean-François , Amieva Hélène , Tabue-Teguo Maturin 
Published: April 2023

AbstractSenior housing for older adults could be an alternative or a transitional care model between home care and nursing home care. Using two longitudinal cohorts of community dwellers aged 65 years or older, we compared risks of mortality and of nursing homes admission between older adults who did or did not move to senior housing over time. In the 3C study (n = 2104, 17 years of follow-up), 143 (6.8%) participants moved into a senior housing during the follow-up. This move was associated with a lower risk of mortality (hazard ratio (HR): 0.64; 95% confidence interval (CI) 0.46–0.77) and a higher risk of nursing home admissions (HR: 1.54 (1.10–2.15)). The risks of hospitalizations (HR: 0.54 (0.40–0.73)) and falls (HR: 0.63 (0.50–0.79)) were lower. In the PAQUID study (n = 3777, 27 years of follow-up), 161 (4.3%) participants moved into a senior housing. This move was also associated with a lower mortality risk (HR: 0.72 (0.58–0.88)) and a higher risk of nursing home admissions (HR: 1.39 (1.05–1.86)). Our results showing lower risks of mortality suggest that senior housing may be a relevant model for vulnerable older adults.