bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adenocarcinoma arising from widespread heterotopic gastric mucosa in the cervicothoracic esophagus: a case report
Authors: Nogi Shohei , Noma Kazuhiro , Hashimoto Masashi , Kato Takuya , Maeda Naoaki , Tanabe Shunsuke , Shirakawa Yasuhiro , Fujiwara Toshiyoshi 
Published: July 2023

Abstract
Background
In Japan, about 6% of esophageal cancers are adenocarcinomas, although most of them arise from Barrett’s epithelium. Adenocarcinoma arising from heterotopic gastric mucosa (HGM) is very rare. Due to its rarity, there is no unified view on its treatment strategy and prognosis.

Case presentation
A 57-year-old man presented with a protruding lesion in the cervicothoracic esophagus that was detected by an upper gastrointestinal series at a medical checkup. Esophagoscopy revealed a 30 mm Type 1 tumor circumferentially surrounded by widespread HGM. Computed tomography (CT) and fluorodeoxyglucose (FDG) positron emission tomography (PET)/CT showed no metastasis or invasion of the surrounding organs. We diagnosed the lesion as cT2N0M0 cStageIIB [Union for International Cancer Control (UICC) 8th Ed] cancer and performed subtotal esophagectomy with three-field lymph node dissection. The tumor was determined to be a well-differentiated adenocarcinoma arising from HGM, with deep invasion of the submucosa. The patient underwent no adjuvant therapy and has currently survived without any evidence of recurrence for 15 months.

Conclusions
Although the treatment for adenocarcinoma arising from HGM is basically the same as that for squamous cell carcinoma (SCC) of the esophagus, it is important to determine the treatment strategy based on the characteristics of the adenocarcinoma arising from HGM.
Oral challenge vs routine care to assess low-risk penicillin allergy in critically ill hospital patients (ORACLE): a pilot randomised controlled trial
Authors: Rose Morgan , Holmes Natasha , Eastwood Glenn , Vogrin Sara , James Fiona , Phung Michelle , Barnes Sara , Murfin Brendan , Rogers Ben , Lambros Belinda , Peel Trisha , Gibney Grace , Slavin Monica , Trubiano Jason 
Published: July 2023

Abstract
Background
Self-reported penicillin allergies are highly prevalent in hospitalised patients and are associated with poor health and health service outcomes. Critically ill patients have historically been underrepresented in prospective delabelling studies in part due to concerns around clinical stability and reliability of penicillin skin testing. Allergy assessment tools exist to identify low-risk penicillin allergy phenotypes and facilitate direct oral challenge delabelling. PEN-FAST is a clinical decision rule that has been validated to predict true penicillin allergy in a cohort of non-critically ill patients. There is however limited evidence regarding the feasibility, safety and efficacy of direct oral challenges and the use of delabelling clinical decisions rules in the intensive care setting.

Methods
Critically ill patients in the intensive care unit (ICU) with low-risk penicillin allergy phenotypes (PEN-FAST score < 3) will be randomised 1:1 to direct oral penicillin challenge (single dose 250 mg oral amoxicillin or implicated penicillin) or routine care, followed by a 2-h observation period. Patients will receive a second oral challenge/observation prior to hospital discharge (with subsequent observation for 2 h). An assessment for antibiotic-associated adverse events will also be undertaken at 24 h and 5 days post each challenge/observation and again at 90 days post-randomisation. The primary outcome measures are feasibility (proportion of eligible patients recruited and protocol compliance) and safety (proportion of patients who experience an antibiotic-associated immune-mediated adverse event or serious adverse event).

Discussion
We will report the feasibility and safety of point-of-care penicillin direct oral challenge in this first randomised controlled trial of low-risk penicillin allergy in critically ill hospitalised patients. Upon completion of the project, important findings will inform the design of planned large prospective multi-centre clinical trials in Australian and international ICUs, further examining safety and efficacy and exploring antimicrobial prescribing-related outcomes following penicillin oral challenge.

Trial registration
Australian New Zealand Clinical Trials Registry
Registration Number: ACTRN12621000051842
Date registered: 20/01/2021
https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=379735&isReview=true
Biological correlates of the neuropsychiatric symptoms in SARS-CoV-2 infection: an updated review
Authors: Mannekote Thippaiah Srinagesh , Amanullah Shabbir , Huang Zi Huai , Goldschmidt Edward , Pradhan Basant 
Published: July 2023

AbstractCoronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome corona virus-2 (SARS-CoV-2) appeared in early 2019 and swiftly became a pandemic causing extensive morbidity and mortality. Many studies have recognized the neuropathological changes in the brain and hypothesized the possible link with cognitive dysfunction, neuropsychiatric symptoms and behavioral disturbances. Potential biological mechanisms may include direct neuronal micro-invasion, disturbances in the neuro-immuno-endocrine system and possibly alteration of neuronal excitability. SARS-CoV-2 facilitates down-regulation of the ACE2 (Angiotensin-2) receptors which could alter inflammatory response through various cellular and neurophysiological systems leading to disturbance in the hypo-thalamopituitary–adrenal (HPA) axis, escalation of the oxidative stress and disruption of the homeostasis of the neurotransmitter system, including serotonin, dopamine and GABA (gamma-aminobutyric acid), eventually resulting in the emergence of neuropsychiatric symptoms. Psychiatric symptoms that emerged are many, some of which may be unique to SARS-CoV-2 infection. These neuropsychiatric symptoms are acute or chronic with possibly distinct etiopathogenesis. This article discusses the possible biological correlates and neurobiology of the psychiatric symptoms of SARS-CoV-2 and their impact on the brain and behavior.
Financial management practices in Islamic donation-based crowdfunding (DCF) platforms in Malaysia
Authors: Kamaruddin Muhammad Iqmal Hisham , Muhamed Nurul Aini , Radzi Rafisah Mat , Nazarie Wan Nur Fazni Wan Mohamad , Kamarubahrin Aimi Fadzirul 
Published: July 2023

AbstractThis study aims to explore current financial management practices covering governance and financial operation aspects in Islamic donation-based crowdfunding (DCF) in Malaysia. A series of interviews with six Islamic DCF platforms in Malaysia were conducted. For reporting purposes, this study employed a single-case study approach. The interview was conducted and completed at the end of August 2022 via an online approach through Google Meet. The findings highlight the governance background in terms of legal establishment as well as monitoring the function of Islamic DCFs in Malaysia. In addition, for financial operation, several findings related to the funding management process model, income generation, financial sustainability and financial disclosure of Islamic DCFs in Malaysia were discussed. This study is among the pioneer studies that explore financial management practices in Islamic DCF platforms in Malaysia. The study findings and recommendations are useful for Islamic DCF platforms as well as related parties like regulators, funders, potential project managers and the public in general to understand financial management practices in Islamic DCF platforms in Malaysia.
Levels of polycyclic aromatic hydrocarbon in the soil around typical automobile repair workshops in Nigeria
Authors: Adesina Olusola Adedayo , Fakayode Oluwatomi Atinuke , Lala Mayowa Adeoye , Adewale Abiodun John , Sonibare Jacob Ademola 
Published: July 2023

Background: This study determined the levels of polycyclic aromatic hydrocarbons (PAHs) in the soil around typical automobile repair workshops in Nigeria. Risk assessment associated with human contact with the soil was carried out using hazard quotient (HQ) and incremental life cancer risk (ILCR) from human unconscious ingestion and dermal contact with the soil. Methods: Soil samples were obtained at different automobile workshops in Ado-Ekiti, Western Nigeria. The PAHS in the samples were extracted using dichloromethane and extracts were cleaned up silica gel open column chromatography. Analysis of PAHs in the soil was done using a gas chromatograph coupled to a mass selective detector operated on electron ionization mode. Results: The results showed the mean PAHs concentration at the sampling locations ranged from 5.58 – 6.4 μg/g and the mean ∑ carcinogenic PAHs was 58.4 μg/g , equivalent to 59.39 % of total PAHs observed. The mean Toxicity equivalence (TEQs) ranged from 0.02 - 6.680 μg/g . Benzo (a) pyrene and dibenzo(a,h)anthracene have the highest toxicity equivalent. The total ILCRs from accidental ingestion and dermal contact in adults were 1 ×10^(-3) and 9.8 ×10^(-5) , for adults and children respectively; both are higher than the permissible limit stipulated by the World Health Organization. The HQs obtained are several folds higher than 1. This implies high carcinogenic and non-carcinogenic risks for children and adults. Conclusions: The study revealed the levels of PAHs and risks associated with human contact with the soil around automobile repair workshop.
Planned vs. Actual Attention
Authors: Avoyan Ala , Ribeiro Mauricio , Schotter Andrew , Schotter Elizabeth R. , Vaziri Mehrdad , Zou Minghao 
Published: July 2023

People often need to plan how to allocate their attention across different tasks. In this paper, we run two experiments to study a stylized version of this attention-allocation problem between strategic tasks. More specifically, we present subjects with pairs of 2 × 2 games, and for each pair, we give them 10 seconds to decide how they would split a fixed time budget between the two games. Then, subjects play both games without time constraints, and we use eye-tracking to estimate the fraction of time they spend on each game. We find that subjects’ planned and actual attention allocation differ and identify the determinants of this mismatch. Further, we argue that misallocations can be relevant in games in which a player’s strategy choice is sensitive to the time taken to reach a decision. This paper was accepted by Yan Chen, behavioral economics and decision analysis. Funding: Work on this project was provided by the National Science Foundation [Grant SES 1724550] “Collaborative Research: Attention in Games and Decisions,” awarded to A. Schotter and E. R. Schotter. The work of M. Ribeiro and M. Zou was supported by the Center for Experimental Economics Social Science at New York University. Supplemental Material: The online appendix and data are available at https://doi.org/10.1287/mnsc.2023.4834 .
Tension-free thyroidectomy (TFT, medial thyroidectomy) — a prospective study: surgical technique and results of 259 operations
Authors: Sleptsov I. V. , Chernikov R. A. , Pushkaruk A. A. , Sablin I. V. , Tilloev T. A. , Timofeeva N. I. , Gerasimova K. A. , Buzanakov D. М. , Shikhmagomedov Sh. Sh. , Alekseeva S. A. , Bubnov A. N. , Osokina Ya. A. , Liubimov M. V. 
Published: July 2023

BACKGROUND: One of the most important tasks in thyroid surgery is to prevent the development of specific complications — laryngeal nerve dysfunction and hypoparathyroidism. A significant number of technical solutions introduced into clinical practice in recent years are aimed at solving this problem.AIM: Тo evaluate the results of an alternative technique of thyroid surgery — medial thyroidectomy.MATERIALS AND METHODS: 270 patients with thyroid diseases were operated on using tension free thyroidectomy technique in the volume of hemi- or thyroidectomy with or without cervical lymphadenectomy. The selection of patients was continuous. All patients underwent ultrasound or videolaryngoscopy before the operation and on the 1st postoperative day. Patients who underwent thyroidectomy underwent blood analysis for parathormone and blood analysis for ionized calcium.RESULTS: For hemithyroidectomy the duration of surgery did not change. In the group of patients with nodes up to 30 mm the duration of surgery increased. An increase in the operation time was also noted for thyroidectomy. Unilateral laryngeal paresis was registered in 6 (2.3%) patients or 1.7% of the number of recurrent laryngeal nerves in the risk area. The risk of parathyroid gland (PTG) removal was 0.39% of the number of operations and 0.14% of the number of PTG in the risk area. Decrease in the level of parathormone in the first day after surgery was noted in 11.5% of patients. The development of postoperative hematoma was noted in 1 patient (0.39%).CONCLUSION: The technique of thyroid surgery with medial access to the recurrent laryngeal nerve and parathyroid glands is feasible in the vast majority of patients with thyroid diseases requiring surgical treatment and shows high safety and a number of advantages over the traditional method of thyroid surgery.
Aggregated data from the same laboratories participating in two glucose external quality assessment schemes show that commutability and transfers of values to control materials are decisive for the biases found
Authors: Gidske Gro , Sandberg Sverre , Fauskanger Pernille , Pelanti Jonna , Tollånes Mette C. , Solsvik Anne E. , Sølvik Una Ø. , Vie Wenche S. , Stavelin Anne 
Published: July 2023

Abstract

Objectives
We report the results of glucose measurements performed during one year by the same measurement procedures (MPs) in 58 Norwegian hospital laboratories using control materials provided by external quality assessment (EQA) schemes from two different providers. The providers used materials with presumed vs. verified commutability and transfers of values using reference material vs. using a highest-order reference MP.

Methods
Data from six Labquality and three Noklus glucose EQA surveys were aggregated for each MP (Abbott Alinity, Abbott Architect, Roche Cobas, and Siemens Advia) in each scheme. For each EQA result, percent difference from target value (% bias) was calculated. Median percent bias for each MP per scheme was then calculated.

Results
The median % biases observed for each MP in the Labquality scheme were significantly larger than those in the Noklus scheme, which uses verified commutable control materials and highest-order reference MP target values. The difference ranged from 1.2 (Roche Cobas, 2.9 vs. 1.7 %) to 4.4 percentage points (Siemens Advia, 3.2 % vs. −1.2 %). The order of bias size for the various MPs was different in the two schemes. In contrast to the Labquality scheme, the median % biases observed in the Noklus scheme for Abbott Alinity (−0.1 %), Abbott Architect (−0.5 %), and Siemens Advia (−1.2 %) were not significantly different from target value (p>0.756).

Conclusions
This study underlines the importance of using verified commutable EQA materials and target values traceable to reference MPs in EQA schemes designed for assessment of metrological traceability of laboratory results.
New Inscribed Bricks of Takil-ilissu, King of Malgûm
Authors: Al-Hussainy Abbas , Jawdat Jacob , Marchesi Gianni 
Published: July 2023

Abstract
In this paper, we publish some remarkable brick inscriptions of Takil-ilissu, king of Malgûm, which were recently found during a survey that led to the identification of Malgûm, the capital of an independent kingdom in the Isin-Larsa period. The bricks come from Tulūl al-Fāj, the site that has been identified as ancient Malgûm. Besides adding new details about Takil-ilissu, a relatively little-known ruler, these inscriptions are noteworthy for containing unusual words, expressions, and clauses.
Super‐resolution microscopy reveals focal organization of ER‐associated Y‐complexes in mitosis
Authors: Gandhimathi Rojapriyadharshini , Pinotsi Dorothea , Köhler Mario , Mansfeld Jörg , Ashiono Caroline , Kleele Tatjana , Pawar Sumit , Kutay Ulrike 
Published: July 2023

AbstractDuring mitotic entry of vertebrate cells, nuclear pore complexes (NPCs) are rapidly disintegrated. NPC disassembly is initiated by hyperphosphorylation of linker nucleoporins (Nups), which leads to the dissociation of FG repeat Nups and relaxation of the nuclear permeability barrier. However, less is known about disintegration of the huge nuclear and cytoplasmic rings, which are formed by annular assemblies of Y‐complexes that are dissociated from NPCs as intact units. Surprisingly, we observe that Y‐complex Nups display slower dissociation kinetics compared with other Nups during in vitro NPC disassembly, indicating a mechanistic difference in the disintegration of Y‐based rings. Intriguingly, biochemical experiments reveal that a fraction of Y‐complexes remains associated with mitotic ER membranes, supporting recent microscopic observations. Visualization of mitotic Y‐complexes by super‐resolution microscopy demonstrates that they form two classes of higher order assemblies: large clusters at kinetochores and small, focal ER‐associated assemblies. These, however, lack features qualifying them as persisting ring‐shaped subassemblies previously proposed to serve as structural templates for NPC reassembly during mitotic exit, which helps to refine current models of nuclear reassembly.
Automatic Scoring Using Term Frequency Inverse Document Frequency Document Frequency and Cosine Similarity
Authors: Yulita Winda , Untoro Meida Cahyo , Praseptiawan Mugi , Ashari Ilham Firman , Afriansyah Aidil , Bin Che Pee Ahmad Naim 
Published: July 2023

Purpose: In the learning process, most of the tests to assess learning achievement have been carried out by providing questions in the form of short answers or essay questions. The variety of answers given by students makes a teacher have to focus on reading them. This scoring process is difficult to guarantee quality if done manually. In addition, each class is taught by a different teacher, which can lead to unequal grades obtained by students due to the influence of differences in teacher experience. Therefore the purpose of this study is to develop an assessment of the answers. Automated short answer scoring is designed to automatically grade and evaluate students' answers based on a series of trained answer documents.Methods: This is ‘how’ you did it. Let readers know exactly what you did to reach your results. For example, did you undertake interviews? Did you carry out an experiment in the lab? What tools, methods, protocols or datasets did you use The method used is TF-IDF-DF and Similarity and scoring computation. Theword weight used is the term Frequency-Inverse Documents Frequency -Document Frequency (TF-IDF-DF) method. The data used is 5 questions with each question answered by 30 students, while the students' answers are assessed by teachers/experts to determine the real score. The study was evaluated by Mean Absolute Error (MAE).Result: The evaluation results obtained Mean Absolute Error (MAE) with a resulting value of 0.123.Value: The word weighting method used is the Term Frequency Inverse Document Frequency DocumentFrequency (TF-IDF-DF) which is an improvement over the Term Frequency Inverse Document Frequency (TF-IDF) method. This method is a method of weighting words that will be applied before calculating the similarity of sentences between teachers and students.
CENOZOIC TECTONIC ACTIVITIES IN RED RIVER BASIN AND ANDJACENT AREA
Authors: Phach Phung Van , Chinh Vu Van 
Published: July 2023

Using cornbinarion of geomorphologic, topographic, remote sensed images, structural features and tectonophysic analysis we have deterrnined 4 principle tectonic phases in Red River Cenozoic Basin and adjacent area as follow (in the order from ancient to recent). The first tectonic phase was characterized by east - west extension. It can be remarked in many places of Ninh Binh province, in particular within Dong Giao limestone forrnation (T2 a dg), with numerous of large sub-longitudinal extensional cracks, filled up by calcite up to meters in thickness. The event can be related to one of the dextral strike slip of Red River fault zone and had participated in the earliest rift - forming process of region. The second tectonic phase had rnainly strike slip nature, with east-west cornpression, that marked as well by cessation of regional rift - forming process in the region (the unconformity of 32-30 M.y.BP), as by onset of Cenozoic oceanic crust spreding of Eastern Vietnam Sea and by sinistral strike - slip of Red River Fault. The third tectonic phase, with maximum NE - SW compression, has caused some significant thrust activities along coastal zone and has stimulated an inverse uplift - shortening in NW part of Red River Basin in the Early - Midle Miocene, with the unconfornities 15.5 and 5.5 M.y.BP. The most recent tectonic phase that is revealed in study area by very recent NE - SW extensions, that creates a numerous of narrow valleys of NW - SE orientation and causes a dextral and a sinistral movements of sub-latitudinal and sub-longitudinal accordingly. This extension can be considered as accompany of intensive extension-subsidence in Red River basin, that contents of 4 km Pliocene - Quaternary sediment in the center.
Hak Tersangka Atas Kejadian Salah Tangkap
Authors: Aisyah Siti , Ambarwati Fanani Sri , Faqihudin Jundullah , Hikmah Putri Silvah Al , Harefa Safaruddin 
Published: July 2023

Penangkapan sering dilakukan dengan tidak menerapkan peraturan yang tercantum dalam ketentuan subjektif dan objektif sebagaimana dilihat dalam KUHAP. Tindakan yang tidak patut untuk dilakukan oleh aparat penegak hukum dalam melakukan upaya paksa sering menimbulkan salah tangkap yang menimbulkan kerugian baik secara verbal maupun non verbal sehingga perlu adanya perlindungan hukum yang diberikan oleh negara yang sudah diatur dalam undang-undang bagi tersangka atau terdakwa atas salah tangkap. Perlindungan hukum kepada tersangka atau terdakwa salah tangkap yang disediakan negara dapat kita perhatikan pada pasal 95 sampai pasal 101 KUHAP selanjutnya penjelasan tentang ganti rugi yang diberikan kepada tersangka atau terdakwa yang salah tangkap akibat adanya pelanggaran hak-hak maupun pelanggaran hukum secara administratife. Penelitian ini menggunakan metode yuridis normati yaitu dengan menganalisis Pasal 95 sampai dengan pasal 101 KUHAP tentang ganti kerugian dan rehabilitasi. Selain menggunakan bahan hukum primer, bahan hukum sekunder yang dipergunakan dalam penelitian ini adalah buku-buku dan jurnal-jurnal yang memuat tentang hak tersangka atau terdakwa untuk meminta ganti rugi. Kesimpulan dari penelitian ini bahwa untuk memberikan perlindungan hukum berupa hak ganti rugi dan rehabilitasi terhadap tersangka atau terdakwasalah tangkap diatur dalam Pasal 95 sampai dengan Pasal 101 KUHAP akibat adanya hak-hak maupun pelanggaran hukum secara administratif dan harus ditegakkan keadilannya tanpa adanya alasan yang jelas yang tidak sesuai dengan aturan perundang-undangan.