bluuebunny/crossref_metadata_2025_split huggingface dataset:
Complex coacervation and freeze drying using whey protein concentrate, soy protein isolate and arabic gum to improve the oxidative stability of chia oil
Authors: Bordón María Gabriela , Barrera Gabriela Noel , González Agustín , Ribotta Pablo Daniel , Martínez Marcela Lilian 
Published: February 2023

AbstractBACKGROUNDChia oil (CO) is popular for being the richest vegetable source of α‐linolenic acid (60–66%). However, this content of polyunsaturated fatty acids (PUFA) limits the incorporation of bulk CO in food products due to its high probability of oxidation. This justifies the study of alternative wall materials for microencapsulation. No reports regarding the use of dairy protein/vegetable protein/polysaccharide blends as wall material for the microencapsulation of CO have been published. Therefore, this work analyzed the behavior of a whey protein concentrate (WPC)/soy protein isolate (SPI)/arabic gum (AG) blend as wall material. The complex coacervation (CC) process was studied: pH, 4.0; total solid content, 30% w/v; WPC/SPI/AG ratio, 8:1:1 w/w/w; stirring speed, 600 rpm; time, 30 min; room temperature.RESULTSThe oxidative stability index (OSI) of CO (3.25 ± 0.16 h) was significantly increased after microencapsulation (around four times higher). Furthermore, the well‐known matrix‐forming ability of AG and WPC helped increase the OSI of microencapsulated oils. Meanwhile, SPI contributed to the increase of the encapsulation efficiency due to its high viscosity. Enhanced properties were observed with CC: encapsulation efficiency (up to 79.88%), OSIs (from 11.25 to 12.52 h) and thermal stability of microcapsules given by the denaturation peak temperatures of WPC (from 77.12 to 86.00 °C). No significant differences were observed in the fatty acid composition of bulk and microencapsulated oils.CONCLUSIONMicrocapsules developed from complex coacervates based on the ternary blend represent promising omega‐3‐rich carriers for being incorporated into functional foods.
Who takes part in film tourism? The analysis of determinants of visiting film locations
Authors: Moritz Peter , Hrivnák Michal , Mazúchová Ľudmila , Sándorová Zuzana 
Published: February 2023

AbstractFilm tourism is one of the fastest developing sub‐segments of creative tourism in the 21st century. Many studies investigated tourists' motivation and behavior towards film tourism in the context of psychological and emotional motives and their involvement and experience. However, we still know very little about the structure of visitors of film sites. Utilizing primary data collected in Slovakia and adopting the econometric approach, the aim of this empirical study is to estimate the relationship between preferred trip parameters and the decision to include a visit to a film location in the travel plan. The results suggest that visits to film sites occur to a significant extent by chance, film tourism is additional, mainly to other segments of tourism, characterized as adventurous and explorative experiences. Visits to film locations occur mainly as trips by younger age groups and longer stays, mostly as self‐organized trips, regardless of budget, frequency of travel, or gender.
Exploring non‐immersive virtual reality experiences in tourism: Empirical evidence from a world heritage site
Authors: Zhu Chris , Wu Don Chi Wai , Hall Colin Michael , Fong Lawrence Hoc Nang , Koupaei Sara Naderi , Lin Feifei 
Published: February 2023

AbstractWith the popularization of the concept of the metaverse, non‐immersive virtual reality (VR) has become a focus of tourism destination marketing. Drawing upon telepresence theory, this study identifies the antecedents and consequences of telepresence to help interpret tourist behavior in the context of non‐immersive VR experience. Results revealed that mental imagery and vividness positively predict tourist telepresence and satisfaction; Telepresence positively predicts satisfaction and intention during non‐immersive VR experiences. Our work enriches telepresence theory by identifying the antecedents and consequences of telepresence in the context of non‐immersive VR, and provides meaningful practical insights for similar attractions that adopt the technology.
The Semicrystalline Morphology of Polybutylene Succinate Supports a General Scheme Based on Intracrystalline Dynamics
Authors: Yu Qiang , Anuar Afiq , Petzold Albrecht , Balko Jens , Saalwächter Kay , Thurn‐Albrecht Thomas 
Published: February 2023

AbstractBased on a limited set of model samples it has been recently shown that semicrystalline polymers exhibit different morphological characteristics depending on the existence and timescale of intracrystalline chain diffusion (ICD) relative to the kinetics of crystal growth. Here, the generality of these reports for the case of so‐called crystal‐fixed polymers without or very slow ICD is tested by providing a detailed nuclear magnetic resonance (NMR) and small‐angle X‐ray scattering analysis of polybutylene succinate (PBS), a biodegradable polyester. By using a combination of NMR techniques covering different timescales it is shown that there is no intracrystalline dynamics on a time scale faster than 1 s, that is, PBS is crystal‐fixed. An expected crystallinity below 50% and the typical morphology consisting of lamellar crystals with a well‐defined crystal thickness and a broad thickness distribution of the amorphous interlayers are confirmed. By combining these results with differential scanning calorimetry measurements, a more precise value could be provided for the enthalpy of melting than previously available. The mechanical properties at room temperature are furthermore influenced by additional insertion crystallization taking place during cooling, which leads to an increase of the mechanical modulus by a factor of ≈2.5 as compared to the state at the end of isothermal crystallization.
Dermal Real‐Time Quaking‐Induced Conversion Is a Sensitive Marker to Confirm Isolated Rapid Eye Movement Sleep Behavior Disorder as an Early α‐Synucleinopathy
Authors: Kuzkina Anastasia , Panzer Celine , Seger Aline , Schmitt Daniela , Rößle Jonas , Schreglmann Sebastian R. , Knacke Henrike , Salabasidou Elena , Kohl Antonia , Sittig Elisabeth , Barbe Michael , Berg Daniela , Volkmann Jens , Sommer Claudia , Oertel Wolfgang H. , Schaeffer Eva , Sommerauer Michael , Janzen Annette , Doppler Kathrin 
Published: February 2023

AbstractBackgroundSkin biopsy is a potential tool for the premortem confirmation of an α‐synucleinopathy.ObjectiveThe aim was to assess the aggregation assay real‐time quaking‐induced conversion (RT‐QuIC) of skin biopsy lysates to confirm isolated rapid eye movement sleep behavior disorder (iRBD) as an α‐synucleinopathy.MethodsSkin biopsies of patients with iRBD, Parkinson's disease (PD), and controls were analyzed using RT‐QuIC and immunohistochemical detection of phospho‐α‐synuclein.Resultsα‐Synuclein aggregation was detected in 97.4% of iRBD patients (78.4% of iRBD biopsies), 87.2% of PD patients (70% of PD biopsies), and 13% of controls (7.9% of control biopsies), with a higher seeding activity in iRBD compared to PD. RT‐QuIC was more sensitive but less specific than immunohistochemistry.ConclusionsDermal RT‐QuIC is a sensitive method to detect α‐synuclein aggregation in iRBD, and high seeding activity may indicate a strong involvement of dermal nerve fibers in these patients. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
Antiangiogenic therapy for ocular diseases: Current status and challenges
Authors: Chen Rongyuan , Zhu Juanhua , Hu Jiaxin , Li Xuri 
Published: February 2023

AbstractAngiogenesis is the process of new blood vessel growth from pre‐existing ones involving vascular endothelial cell activation, proliferation, migration, and tube formation. The vascular endothelial growth factor A (VEGF‐A) is known to be a key factor that promotes angiogenesis. Pathological angiogenesis is a key and common feature of numerous ocular neovascular diseases, such as wet age‐related macular degeneration, diabetic retinopathy, retinopathy of prematurity, retinal vein occlusion, and corneal neovascularization. Although anti‐VEGF treatment has been a great success for the treatment of such ocular neovascular diseases, many challenges exist, such as limited efficacy, unresponsiveness in many patients, drug resistance, treatment burden due to repeated intravitreous injection, all of which incent much effort and enthusiasm to find new and better treatment for ocular neovascular diseases. In recent years, new antiangiogenic drug, targets and drug delivery methods have been developed. This perspective discusses the status of currently available therapies, challenges, opportunities, and potential new directions toward better therapies for ocular neovascular diseases.
Stabilization in a two‐dimensional fractional chemotaxis‐Navier–Stokes system with logistic source
Authors: Lei Yuzhu , Liu Zuhan , Zhou Ling 
Published: February 2023

This paper investigates a chemotaxis‐Navier–Stokes system with logistic source and a fractional diffusion of order

on the two‐dimensional periodic torus
. It is proved that if
and the initial data
satisfy some regular conditions, the considered problem admits a global classical solution. Through constructing a new Lyapunov functional different from the previous literature, we can obtain the following asymptotic stabilization:

If
, the solution components
and
satisfy

If
and
, where
is a constant determined in (6.24), the solution components
and
satisfy

In either case, the solution component
satisfies
Improving working volume and total scattering cross section using polarization convertor stirrer in a reverberation chamber
Authors: Lin Weihao , Kong Xiangkun , Xu Qian , Fang Feng , Xia Wenjun , Qi Wenjun 
Published: February 2023

AbstractIn our paper, a stirrer made of a polarization converter for a reverberation chamber (RC) is proposed. A cylindrical polarization converter (PC) stirrer with two unit structures arranged alternatively is placed in RC to take the place of a traditional metallic stirrer. Because of the scattering property of the PC stirrer, it is possible to enlarge the working volume and improve the scattering performance of the stirrer in the RC while maintaining the field uniformity and field anisotropy coefficient to meet the testing standard of the International Electrotechnical Commission 61000‐4‐21. Metallic stirrer and PC stirrer are both placed in the RC simultaneously to make a measurement for guaranteeing the same testing environment. Some parameters of the RC stirred by the PC stirrer or metallic stirrer have been measured and analyzed, such as field uniformity, field anisotropy, coefficient independent sample number and total scattering cross‐section (TSCS), and so on. Testing results verify that the RC stirred by a PC stirrer outperforms the classic RC stirred by a conventional metallic stirrer in terms of some performance, indicating that the proposal has a significant impact on RC testing technology that requires a larger working volume and better TSCS.
Assisted annotation in Deep LOGISMOS: Simultaneous multi‐compartment 3D MRI segmentation of calf muscles
Authors: Zhang Lichun , Guo Zhihui , Zhang Honghai , van der Plas Ellen , Koscik Timothy R. , Nopoulos Peggy C. , Sonka Milan 
Published: February 2023

AbstractBackgroundAutomated segmentation of individual calf muscle compartments in 3D MR images is gaining importance in diagnosing muscle disease, monitoring its progression, and prediction of the disease course. Although deep convolutional neural networks have ushered in a revolution in medical image segmentation, achieving clinically acceptable results is a challenging task and the availability of sufficiently large annotated datasets still limits their applicability.PurposeIn this paper, we present a novel approach combing deep learning and graph optimization in the paradigm of assisted annotation for solving general segmentation problems in 3D, 4D, and generally n‐D with limited annotation cost.MethodsDeep LOGISMOS combines deep‐learning‐based pre‐segmentation of objects of interest provided by our convolutional neural network, FilterNet+, and our 3D multi‐objects LOGISMOS framework (layered optimal graph image segmentation of multiple objects and surfaces) that uses newly designed trainable machine‐learned cost functions. In the paradigm of assisted annotation, multi‐object JEI for efficient editing of automated Deep LOGISMOS segmentation was employed to form a new larger training set with significant decrease of manual tracing effort.ResultsWe have evaluated our method on 350 lower leg (left/right) T1‐weighted MR images from 93 subjects (47 healthy, 46 patients with muscular morbidity) by fourfold cross‐validation. Compared with the fully manual annotation approach, the annotation cost with assisted annotation is reduced by 95%, from 8 h to 25 min in this study. The experimental results showed average Dice similarity coefficient (DSC) of and average absolute surface positioning error of 0.63 pixels (0.44 mm) for the five 3D muscle compartments for each leg. These results significantly improve our previously reported method and outperform the state‐of‐the‐art nnUNet method.ConclusionsOur proposed approach can not only dramatically reduce the expert's annotation efforts but also significantly improve the segmentation performance compared to the state‐of‐the‐art nnUNet method. The notable performance improvements suggest the clinical‐use potential of our new fully automated simultaneous segmentation of calf muscle compartments.
Crucial interactions of functional pyrenes with graphite in electrodes for lithium‐ion batteries
Authors: Bauer Marina , Konnerth Philipp , Radinger Hannes , Pfeifer Kristina , Joshi Yug , Bauer Felix , Ehrenberg Helmut , Scheiba Frieder 
Published: February 2023

AbstractPolycyclic aromatic hydrocarbons, such as pyrenes, are a well‐known material class for non‐covalent modification of carbon surfaces in many applications. In electrochemical energy storage, pyrenes are mostly used in large polymeric structures. This work addresses the use of carboxy‐ and amino‐functionalized pyrenes for graphite electrodes for lithium‐ion batteries (LIBs). Pyrenes are explored as adsorbed species on graphite prior to electrode fabrication and as additives to the electrode composition. Thereby, 1‐pyrenecarboxylic acid, 1‐pyrenebutyric acid, 1‐aminopyrene, and 1‐pyrenebutylamine were under investigation. As additives, pyrenes do not influence the cycling performance of the electrode at low current but deteriorate the performance at high current, regardless of the functional group. However, when the pyrenes are adsorbed to the graphite surface, the influence of the different functional groups becomes clearly visible, revealing that an additional butyl group has a positive impact on the cycling performance and lithium‐ion transport of the electrodes. Electrodes with 1‐pyrenebutyric acid even enhanced the performance compared to the pristine electrode.
Characteristic association of symbol coding test score with occupational function in Japanese patients with schizophrenia
Authors: Watanabe Yukako , Kanata Sho , Suga Motomu , Inagaki Akiko , Sato Sayaka , Hayashi Naoki , Kunugi Hiroshi , Ikebuchi Emi 
Published: February 2023

AbstractAimStudies showed that cognitive function affects occupational function in patients with schizophrenia. This study aimed to determine the effects of cognitive function on occupational function in Japanese patients with schizophrenia using the Brief Assessment of Cognition in Schizophrenia (BACS).MethodsParticipants were 198 outpatients with schizophrenia or schizoaffective disorder (66 females; mean age 34.5 ± 6.8 years). Occupational function was assessed using the work subscale of the Life Assessment Scale for Mental Ill (LASMI‐w). Multiple regression analysis was performed using the BACS as the independent variable and LASMI‐w as the dependent variable. Furthermore, we divided the LASMI‐w score into three groups, <11, 11–20, and >21, and performed a multinomial logistic regression analysis.ResultsMultiple regression analysis revealed that LASMI‐w score was negatively associated with BACS composite score (β = −0.20, p < 0.01). Among the sub‐items of the BACS, only the symbol‐coding score showed a significant negative association (β = −0.19, p < 0.05). Multinomial logistic analysis showed that the better the composite and symbol coding scores, the smaller the impairment of the occupational function (composite score: β = 2.39 between mild and moderate occupational impairments, p < 0.05; symbol coding score: β = 2.44 between mild and severe impairments, p < 0.05).ConclusionThe occupational function of patients with schizophrenia was associated with overall cognitive function (composite score). In particular, the symbol coding score of the BACS was suggested to be related to work ability. These results might be useful in the assessment and training of cognitive rehabilitation aimed at employment support.
Synthesis and characterization of poly(1,2,3‐triazole)s with inherent high sulfur content for optical applications
Authors: Mazumder Kajari , Komber Hartmut , Bittrich Eva , Voit Brigitte , Banerjee Susanta 
Published: February 2023

AbstractThe synthesis of solution‐processable sulfur‐containing polytriazoles for optoelectronic applications is a relatively less explored domain in polymer research. The synthesis of novel bifunctional (DA) and trifunctional (TA) azido‐monomers with inherent high sulfur content and of organo‐soluble high refractive index poly(1,2,3‐triazole)s using the azido‐monomers via Cu(I) assisted click polymerization reactions are reported in this work. The azido‐monomers were synthesized by the conversion of previously reported amine‐functionalized compounds to azides using azidotrimethylsilane in a polar aprotic solvent. Dialkyne monomers were also synthesized and reacted with the azides to prepare a series of five linear and two hyperbranched poly(1,2,3‐triazole)s. Fourier transform infrared spectroscopy, nuclear magnetic resonance spectroscopy, differential scanning calorimetry and thermogravimetric analysis were used to characterize the synthesized polymers. It was also demonstrated that the use of the trifunctional azide in optimized conditions resulted in increased solubility of an otherwise insoluble linear poly(1,2,3‐triazole). The optical characterization of the polymers was carried out on thin polymer films with thickness in the nanometer range, which were successfully prepared by spin‐coating on silicon wafers. It was found that the increase in the sulfur and aromatic content in the polymer backbone successfully increased the refractive index of the polymers up to 1.743 at 589 nm.
Physical activity levels, pulmonary function, and MRI in children born extremely preterm: A comparison between children with and without bronchopulmonary dysplasia
Authors: Roeper Rhiana , Blinder Henrietta , Hayawi Lamia , Barrowman Nicholas , Luu Thuy Mai , Moraes Theo J. , Tse Sze Man , Parraga Grace , Santyr Giles , Chaput Jean‐Philippe , Momoli Franco , Thébaud Bernard , Abdeen Nishard , Deschenes Sylvain , Couch Marcus J. , Nuyt Anne‐Monique , Fadel Nadya B. , Katz Sherri L. 
Published: February 2023

AbstractIntroductionChildren with a history of bronchopulmonary dysplasia (BPD) may have lower physical activity levels, but evidence to date is mixed. This study compared physical activity levels between children born extremely preterm with and without history of BPD, and examined their associations with pulmonary magnetic resonance imaging (MRI) and pulmonary function test (PFT) indices.MethodsThis multicentre cross‐sectional study included children aged 7–9 years born extremely preterm, with and without BPD. Children wore a pedometer for 1 week, then completed the Physical Activity Questionnaire (PAQ), pulmonary MRI, and PFT. Spearman correlations and multivariable linear regression modeling were performed.ResultsOf 45 children, 28 had a history of moderate‐severe BPD. There were no differences in any physical activity outcomes by BPD status. Higher average daily step count and higher average daily moderate‐to‐vigorous physical activity (MVPA) were each correlated with greater forced vital capacity (r = 0.41 and 0.58), greater MRI lung proton density at full expiration (r = 0.42 and 0.49), and lower lung clearance index (r = −0.50 and −0.41). After adjusting for MRI total proton density and BPD status, a 5% increase in forced expiratory volume at 1 s was associated with 738 (95% CI: 208, 1268) more steps per day and 0.1 (0.0, 0.2) more hours of MVPA, respectively.ConclusionSchool‐aged children born extremely preterm have similar physical activity levels to their peers, regardless of history of BPD. MRI and PFT measures suggestive of gas trapping and/or airflow obstruction are associated with lower physical activity levels.
Large‐scale population survey of Leptosphaeria maculans in France highlights both on‐going breakdowns and potentially effective resistance genes in oilseed rape
Authors: Balesdent Marie‐Hélène , Laval Valérie , Noah Julie Marie , Bagot Patrick , Mousseau Arnaud , Rouxel Thierry 
Published: February 2023

AbstractBACKGROUNDLeptosphaeria maculans, the cause of stem canker of oilseed rape, develops gene‐for‐gene interactions with its host and shows a high evolutionary potential to ‘break down’ novel resistance genes (R, Rlm) deployed in cultivars over large areas. For optimal management of R genes, updated knowledge of the population structure of the pathogen is needed. In France, large‐scale surveys have been done at 10‐year intervals since 2000. Here we report the characterization of a large L. maculans population collected in France in 2019–2020.RESULTSA total of 844 isolates were collected from 11 sites in ten French departments and were phenotyped for their virulence against nine Brassica napus R genes. All isolates were virulent toward Rlm2 and Rlm9. Very few isolates were avirulent on Rlm1 (1.8%) and Rlm4 (0.6%). Avirulent isolates toward Rlm7 (‘AvrLm7’) varied from 67% to 11.3%, depending on the site sampled, illustrating the ongoing breakdown of Rlm7. The decrease of AvrLm7 isolates (29.2% at the national level) compared to the 2010 survey (96.5%) was accompanied by an increase of avirulent isolates on Rlm3 (0% in 2010; 54% in 2019–2020). However, virulent isolates on both Rlm3 and Rlm7, previously rarely detected, were found in all sites with a frequency of 17.3%. Finally, most or all isolates were avirulent on Rlm11 (96.1%), LepR2 (RlmS, 99.8%), and Rlm6 (100%), suggesting these three genes still effectively control the disease.CONCLUSIONThese data will help guide strategies for breeding and deploying resistant oilseed rape varieties against L. maculans in France. © 2023 The Authors. Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.