bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long‐term outcomes following ileocolic resection for Crohn's disease: does earlier elective resection affect disease recurrence rates?
Authors: Assaf Dan , Hazzan David , Laks Shachar , Segev Lior 
Published: August 2023

AbstractBackgroundSurgical resection in Crohn's disease is sometimes the only alternative treating disease complications or refractory disease. The implications of early resection on disease course are still debatable. We aimed to assess the influence of preoperative disease duration on long‐term postoperative disease course.MethodsA retrospective analysis of all Crohn's disease patients who underwent an elective primary ileocolic resection between 2010 and 2021 in a single tertiary medical center. The cohort was divided based on disease duration, Group A (47 patients) had a disease duration shorter than 3 years (median of 1 year) and Group B (139 patients) had a disease duration longer than 3 years (median of 11 years).ResultsSurgeries were less complex among Group A as noted by higher rates of laparoscopic assisted procedures (68.1% vs. 45.3%, P = 0.006), shorter surgery duration (134 vs. 167 min, P < 0.0001) less estimated blood loss (72.5 vs. 333 mL, P = 0.016) and faster return of bowel function (3 vs. 4 days, P = 0.011). However, propensity score matching nullified all the differences. Younger age (OR = 0.86, P = 0.004), pre‐op steroids (OR = 3.69, P = 0.037) and longer disease duration (OR = 1.18, P = 0.012) were found to be independently significantly associated with severe complications. After a median follow‐up time of 71.38 months no significant differences were found between the groups in terms of endoscopic (P = 0.59), or surgical recurrences rates (P = 0.82).ConclusionsThe main effect of preoperative short disease duration was noted within the surgical complexity; however, matching suggests confounders as cause of the difference. No significant long‐term implication was noted on disease recurrence.
Beyond conventional models: Lending by Native Community Development Financial Institutions
Authors: Dimitrova‐Grajzl Valentina , Grajzl Peter , Guse Joseph , Kokodoko Michou , Wheeler Laurel 
Published: August 2023

AbstractNative Community Development Financial Institutions (Native CDFIs) have become an increasingly important source of credit and financial services in the areas on or near American Indian reservations in the United States. Guided by a conceptual framework developed on the basis of the related finance literature and drawing on loan‐level data from eleven Native CDFI loan funds, we offer the first systematic quantitative analysis of lending in the Native CDFI industry. As hypothesized, Native CDFIs on average give out small loans but support borrowers in varied circumstances with diverse loan products. Important predictors of delinquency include both conventional, hard information‐based, measures of client risk, and alternative, soft information‐based, community‐informed and character‐based measures. Overall, these findings lend strong support to holistic approaches for assessing client creditworthiness for Native CDFI operations. More generally, our analysis contributes new insights into the operations of an industry that plays an instrumental role in removing barriers to socioeconomic development in Native communities.
Pharmacokinetics, pharmacodynamics and safety of LPM3480392 in two phase I clinical trials in healthy Chinese male subjects
Authors: Yang Dan‐dan , Wang Jia‐ying , Ruan Zou‐rong , Jiang Bo , Xu Yi‐Chao , Hu Yin , Che Xin , Zhang Yu‐peng , Lou Hong‐gang 
Published: August 2023

AbstractDrugs for acute postoperative pain and breakthrough cancer pain are still urgent in clinical. LPM3480392 is a G‐protein‐biased ligand at the μ‐opioid receptor and showed potent analgesia in nonclinical studies. Two phase I studies of LPM3480392 were conducted in healthy Chinese male volunteers to explore its tolerability, pharmacokinetics and pharmacodynamics under single ascending doses (Study I 0.1–3.0 mg, 30 min) and different infusion times (Study II, 0.6–1.0 mg, 2–15 min). There was one serious adverse event (AE) observed in Study II, and the rest AEs were mild or moderate in severity and resolved by the end of the study. Plasma LPM3480392 maximum concentration (Cmax) (under lower infusion rate) and area under the plasma concentration‐time curve (AUCs) were generally increased with dose. Moreover, LPM3480392 at a dose of 0.6 mg under a 2 min infusion rate elicited effective analgesia as the peak effect within 10–30 min, which was measured by cold pain test and pupillometry. These findings suggest that LPM3480392 could be a potential treatment for acute pain management.
Freedom, diseases, and public health restrictions
Authors: Giubilini Alberto 
Published: August 2023

AbstractThe debate around lockdowns as a response to the recent pandemic is typically framed in terms of a tension between freedom and health. However, on some views, protection of health or reduction of virus‐related risks can also contribute to freedom. Therefore, there might be no tension between freedom and health in public health restrictions. I argue that such views fail to appreciate the different understandings of freedom that are involved in the trade‐off between freedom and health. Grasping these distinctions would allow to appreciate why different people give more weight to different aspects of limitations of freedom, including whether certain options are made simply risky or impossible, whether limitations of freedom are posed intentionally or happen accidentally, whether risks are beyond a threshold of acceptability, and who gets to decide that. I provide a conceptual analysis of the relationship between different types of freedom, public health policies, viruses and diseases. As I argue, identifying what freedom‐based reasons count for and against different types of public health restrictions requires distinguishing between viruses and diseases, between lockdowns and other types of restrictive policies, and between risks posed by viruses and threats of penalties involved by restrictive policies.
Preemptive effects of etoricoxib, acetaminophen, nimesulide, and ibuprofen on postoperative pain management after single‐implant surgery: A randomized clinical trial
Authors: Mattos‐Pereira Gustavo Henrique , Esteves‐Lima Rafael Paschoal , Cota Luís Otávio Miranda , Alvarenga‐Brant Rachel , Costa Fernando Oliveira 
Published: August 2023

AbstractBackgroundThere is insufficient evidence for pain control in preemptive analgesia (PA) after dental implant surgery, signaling the need for further studies. The objective of this study was to evaluate the efficacy of PA in single dental implant surgeries (SDIS), seeking to identify among the etoricoxib (ETOR), ibuprofen (IBU), nimesulide (NIME), and acetaminophen (ACETA)], which one has the higher efficacy effectiveness in relieving postoperative pain and reducing the use of rescue medication compared to placebo.MethodsIn this triple‐blind, parallel, randomized controlled clinical trial, 135 individuals with a mean age of 57.6 years (±11.7), both genders, were randomly divided into five groups according to the test drug: I—PLACEBO; II—IBU (600 mg); III—NIME (100 mg); IV—ACETA (750 mg); and V—ETOR (90 mg). The occurrence, duration, and intensity of pain were analyzed using the Chi‐square, Fisher's exact and ANOVA tests, and the generalized estimating equation models, when appropriate.ResultsTest drugs provided a reduction in postoperative pain scores and lower use of rescue medication when compared to placebo. The ETOR group presented significantly lower pain scores, when compared to other active treatments. The IBU group showed the highest mean number of rescue medication used.ConclusionsAll test drugs provided a beneficial preemptive effect demonstrated by the reduced postoperative pain and reduced use of rescue medication. The ETOR group presented lower pain scores, and the IBU group showed the highest mean number of rescue medication used among the test groups.
Cardiac and renal outcomes of direct oral anticoagulants in patients with atrial fibrillation
Authors: Wang Yu‐Ting , Chen Jo‐Hsin , Liao Shu‐Fen , Chen Yu‐Jen , Lip Gregory Y. H. , Yeh Jong‐Shiuan 
Published: August 2023

AbstractBackgroundOral anticoagulation therapy with warfarin or direct oral anticoagulants (DOACs) is the mainstay for stroke prevention in patients with non‐valvular atrial fibrillation (AF). The DOACs might have a lower risk of declining renal function than warfarin. This study aimed to compare renal outcomes among rivaroxaban, edoxaban, dabigatran, and warfarin.MethodThis cohort study identified 2203 adults with AF who started anticoagulation therapy between 1 July 2013 and 31 December 2020, in a clinical database at a single centre. Inverse probability of treatment weighting was adopted to balance baseline characteristics among four anticoagulants treatment groups. The primary outcome was a composite of cardiac and renal outcomes, involving a ≥30% decline in estimated glomerular filtration rate (eGFR), renal failure and cardiovascular death.ResultsAfter propensity score weighting, dabigatran was associated with significantly lower risks of a ≥30% decline in eGFR (hazard ratio [HR]: .69, 95% confidence interval [CI]: .497–.951, p = .0237), doubling of the serum creatinine level (HR: .49, 95% CI: .259–.927, p = .0282) and the cardiac and renal outcome composite (HR: .67, 95% CI: .485–.913, p = .0115) than warfarin. Rivaroxaban and edoxaban did not show significant protective effects on renal outcomes compared to warfarin.ConclusionIn this study, patients treated with dabigatran had significantly reduced risks of declining renal function and composite cardiac and renal events than those treated with warfarin. However, rivaroxaban and edoxaban were not associated with lower risks of any renal outcomes than warfarin. More studies are warranted to investigate and compare the impact of renal function between different DOACs in patients with AF.
Risk factors associated with traumatic dental injuries in individuals with special healthcare needs—A systematic review and meta‐analysis
Authors: Devi K. Pavithra , Tewari Nitesh , O'Connell Anne , Srivastav Sukeshana , Rajeswary Amritha , Upadhyay Ashish Dutt , Haldar Partha , Rahul Morankar , Mathur Vijay Prakash , Bansal Kalpana 
Published: August 2023

AbstractBackground/AimIndividuals with special healthcare needs (SHCN) are more likely to sustain traumatic dental injuries (TDIs) due to distinct risk factors. The aim of this review was to assess various risk factors associated with TDIs in individuals with SHCN.Materials and MethodsThe protocol was designed according to the recommendations of the Cochrane‐handbook, Joanna Briggs Institute, and the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) guidelines and registered in PROSPERO (CRD42022357422). A comprehensive search was performed in PubMed, LILACS, Web of Science, EMBASE and Scopus using a pre‐defined strategy without any limitation of language and year of publication. It was last updated on 25 April 2023. Studies addressing the TDIs in individuals with SHCN were included. Data extraction and analyses were performed, risk of bias (ROB) assessment was done using the Joanna Briggs Institute's critical appraisal tool, and a meta‐analysis was performed using random‐effects model.ResultsA total of 21 studies were included in the review. They were categorized according to the target disease/condition: cerebral palsy (n = 5), ADHD and autism spectrum disorders (n = 5), visually impaired (n = 4), and multiple disorders (n = 7). The studies showed variability in the design and methods; however, 17 out of 21 studies showed moderate to low ROB. Increased overjet and lip incompetence were the main risk factors reported in the studies. The commonest injuries were observed to be enamel and enamel and dentine fractures.ConclusionThe overall pooled prevalence of TDI in individuals with special healthcare needs was 23.16% with 20.98% in males and 27.06% in females. Overjet >3 mm and inadequate lip coverage were found to be associated with a higher risk of TDI in all the categories of individuals with special healthcare needs except ADHD and ASD. Falls at home in cerebral palsy, falls while walking and self‐harm in ADHD and ASD, falls at home and collision in visual impairment, and unspecified falls in multiple disorders could be identified as the most common cause of TDI.
Patient‐specific virtual simulation in the clinical training for prosthetic dentistry
Authors: Slaidina Anda , Ozolins Karlis , Berzina Sandra , Abeltins Andris 
Published: August 2023

AbstractIntroductionDental education always involves live patient treatment, and clinical training for each patient is different for students. Using an intraoral scanner and Simodont Dental Trainer, we can provide students with an opportunity to train on actual patient cases in a virtual environment before real preparation. This study aimed to develop, implement and test patient‐specific virtual simulation training in prosthetic dentistry curriculum.Materials and MethodsBefore the actual preparation, the students' patients were scanned using 3Shape intraoral scanner. Thereafter, the .stl file was uploaded to Simodont Dental Trainer (Nissin dental products) where all the scanned teeth were prepared virtually. The ‘prepared’ .stl file was downloaded and submitted to the teacher. Instruction manuals for virtual simulation patient‐specific tasks were provided. The students were asked to voluntarily complete the survey, at the end of the course.ResultsForty‐two 4th year students from the Faculty of Dentistry performed a patient‐specific virtual simulation training task and completed a survey. The created training materials served as guidelines for students to perform all the steps on their own without teacher assistance, except in the final step, where the teacher evaluated the digital preparation. Students appreciated the amount of information provided regarding the technologies used and patient‐specific tasks. Students admitted that the patient‐specific task was more interesting than standard tasks. However, they were not satisfied with the technical performance of Simodont Dental Trainer or the reflection of reality.ConclusionPatient‐specific virtual simulation can be accepted by students for training before actual teeth preparation in the clinic. However, technical improvements are required in this regard.
Financial uncertainty and stock market volatility
Authors: Jiang Ying , Liu Xiaoquan , Lu Zhenyu 
Published: August 2023

AbstractThis study explores the relation between financial uncertainty and volatility in China. The time variation in financial uncertainty shocks is theoretically closely related to stock return dynamics. Empirically, the financial uncertainty measure is based on a large set of economic and financial variables and captures its unpredictable component. Over the sample period from 2000 to 2021, we find that financial uncertainty positively impacts the trend component of market volatility and that it improves volatility predictions in both statistical and economic terms. Our study sheds new light on the sources driving volatility and the dynamic relation between uncertainty and volatility components.
Elevated serum fibrinogen levels in Chinese patients with minor recurrent aphthous stomatitis: An observational study
Authors: Yao Hui , Deng Yiwen , Du Guanhuan , Wang Yufeng , Tang Guoyao 
Published: August 2023

AbstractFibrinogen is a protein that reflects systemic inflammation and regulates the immune response to disease. However, there is a scarcity of data on fibrinogen in recurrent aphthous stomatitis (RAS). We aimed to test the hypothesis that fibrinogen is involved in the aetiology of RAS. Between November 2016 and November 2018, we included 109 minor RAS patients and 29 age‐ and sex‐matched controls in a single‐center, observational study. Their clinical history and ulcer manifestations led to the diagnosis of minor RAS. The ulcer severity score (USS) was used to assess disease severity, and fibrinogen was also collected. We conducted three analyses: Analysis 1 (comparison of fibrinogen levels between patients and controls), Analysis 2 (comparison of fibrinogen levels between high and low USS patients) and Analysis 3 (comparison of fibrinogen levels between before and after anti‐inflammatory treatment in patients). The fibrinogen levels in the 109 minor RAS patients were statistically higher than in the 29 controls (mean [SD], 2.6 [0.5] vs. 2.3 [0.3]; Student's t‐test, p < 0.001). However, there were no significant differences in fibrinogen levels among the 43 patients with high USS and the 39 patients with low USS (mean [SD], 2.7 [0.5] vs. 2.6 [0.4]; Student's t‐test, p = 0.278). Furthermore, fibrinogen levels were significantly higher before anti‐inflammatory treatment in comparison to those after anti‐inflammatory treatment in the 35 paired patients (mean [SD], 2.6 [0.4] vs. 2.5 [0.4]; Student's t‐test, p = 0.026). Interestingly, fibrinogen levels were significantly higher in the 35 paired patients after anti‐inflammatory treatment compared to the 29 control subjects (mean [SD], 2.5 [0.4] vs. 2.3 [0.3]; Student's t‐test, p = 0.026]. Fibrinogen may play a role in the aetiology of RAS and may be a drug target for RAS treatment. Clinicians should be alert that high serum fibrinogen levels might be associated with the risk of RAS.
Effectiveness of community‐based family‐focused interventions on family functioning among families of children with chronic health conditions: A systematic review and meta‐analysis
Authors: Nur Anasthasha Bte Sudar Sono , Chua Joelle Yan Xin , Shorey Shefaly 
Published: August 2023

AbstractCommunity‐based family‐focused interventions can offer support to families of children with chronic health conditions. This review aimed to evaluate the effectiveness of community‐based family‐focused interventions in improving family functioning, disease knowledge, and child health outcomes among families of children with chronic health conditions. Eight electronic databases (MEDLINE, EMBASE, CINAHL, CENTRAL, PsycINFO, Scopus, Web of Science, and ProQuest Dissertations & Theses Global) and one trial registry (ClinicalTrials.gov) were searched from their dates of inception to October 2022. Meta‐analysis was performed under the random‐effect model when appropriate otherwise, findings were narratively synthesized. I2 statistics and Cochran's Q chi‐squared test were used to determine heterogeneity. Quality appraisal was conducted by the Cochrane risk of bias tool and the Grades of Recommendation, Assessment, Development, and Evaluation approach at the study and outcome level, respectively. The Preferred Reporting Items for Systematic Reviews and Meta‐Analyses guidelines guided this review. Eight studies were included in this review. Community‐based family‐focused interventions were viable methods that could support families of children with chronic health conditions. Family‐focused interventions that incorporate guided role‐playing exercises for parents and children, psychoeducational components, and elements from relationship‐focused interventions could support families more effectively. However, current findings are mostly limited to interventions conducted in patients' homes, and the long‐term effect of these interventions cannot be determined. Overall, community‐based family‐focused interventions have the potential to offer valuable support to families of children with chronic health conditions, and future research could seek to improve the effectiveness of these interventions.
Why are conflicts about race a point of no return for feminist organizations?
Authors: Dorion Léa 
Published: August 2023

AbstractThis article seeks to advance scholarship on conflict in feminist organizations. Using the theoretical framework on agonistic conflict of Chantal Mouffe, it analyzes a conflict about racism that arose in a feminist lesbian, bi and trans social movement organization, located in Paris (France). The main contribution lies in offering a framework to analyze the mechanisms that prevented this conflict from constructively fostering the intersectional politics of the feminist organization. The ethnographic findings show that the organization's inability to challenge its racism and whiteness is linked to its post‐political vision of feminism, which translates into attempts to suppress conflict related to multiple and competing identifications. Thus, this article contributes to existing research on conflict in feminist organizing by suggesting that the subduing of conflict associated with such a post‐political vision of feminism prevents feminist organizing from being “anti‐oppressive”.
Understanding the gaps in headache and migraine treatment with psychological and behavioral interventions: A narrative review
Authors: Zamir Orit , Yarns Brandon C. , Lagman‐Bartolome Ana Marissa , Jobanputra Lina , Lawler Valerie , Lay Christine 
Published: August 2023

AbstractObjectiveIn this narrative review, we summarize relevant literature pertaining to psychosocial risk factors for headache and migraine progression, current behavioral and psychological treatments, and consider promising treatments.BackgroundHeadache and migraine are common and associated with significant burden and disability. Current treatments targeting psychosocial risk factors show modest outcomes and do not directly address the impact of early life adversity, including the development of maladaptive emotional processing. An intervention that could address these factors and include components of current evidence‐based interventions may lead to improved outcomes.MethodsWe searched PubMed and Google Scholar for articles through December 2022. Search terms included headache, migraine, psychological interventions, behavioral interventions, cognitive–behavioral therapy, mindfulness, psychiatric comorbidities, adverse childhood experiences, trauma, and emotional processing.ResultsTrauma and childhood adversity show a correlation with headache and migraine progression. Developmental adversity and trauma interfere with adaptive emotional processing, which may worsen headache and migraine symptoms, while adaptive ways of experiencing emotions are shown to improve symptoms. Current behavioral and psychological interventions, such as cognitive–behavioral and mindfulness therapies, are effective treatments for headache, but they produce small to medium effect sizes and do not directly address the impact of trauma and emotional conflicts—common factors that contribute to chronicity and disability, especially among certain subpopulations of headache patients such as those with migraine. Thus, there exists a gap in current treatment.ConclusionThere is a gap in headache and migraine treatment for those patients who have a history of trauma, childhood adversity, and maladaptive emotional processing. We suggest that an integrated psychological treatment that includes components of current evidence‐based interventions and addresses gaps by focusing on processing trauma‐related emotions may improve chronic and debilitating symptoms.