bluuebunny/crossref_metadata_2025_split huggingface dataset:
The person within: Parents and professionals’ views about the practitioner’s role in a parenting program
Authors: Leitão Sara M. , Francisco Rita , Gaspar Maria Filomena , Seabra-Santos Maria João 
Published: March 2023

AbstractPractitioners’ characteristics and actions influence the implementation of evidence-based programs, but little is known about the practitioner’s role in the implementation of parent-based programs. The present qualitative study is the first to explore the perceptions of parents and professionals regarding the practitioners’ characteristics and actions which influence the implementation of a parent program directed at children’s behavior problems. Using thematic analysis, data were examined from eight focus groups comprising 24 parents and 19 practitioners who have participated in the Incredible Years parent group program (IYPP). The analysis identified three groups of practitioners’ characteristics perceived to impact the implementation of the IYPP: inferred interpersonal characteristics (genuine interest; empathy and warmth; positive regard; humbleness); inferred intrapersonal characteristics (objectivity; flexibility; well-being; reflexiveness) and objective characteristics (similar age; being a parent; clinical professional background; professional experience with children and the IYPP). These personal characteristics are perceived as serving to underpin practitioners’ actions, and an integrated framework model is proposed where specific practitioners’ actions are understood in relation to personal characteristics. Inferred characteristics are perceived as determinants in the intervention process while objective characteristics are seen as facilitators of parent engagement in the earliest stages of intervention. Finally, most of the characteristics and actions perceived as relevant in this study are contemplated in the IYPP model; however, the practitioners’ intrapersonal well-being, self-reflexiveness and genuineness emerged as characteristics which may merit further consideration. The results from this study suggest that in the IYPP the person of the practitioner may indeed be worthy of more critical examination.
Multi-Stage NMPC for a MAV based Collision Free Navigation Under Varying Communication Delays
Authors: Papadimitriou Andreas , Jafari Hedyeh , Mansouri Sina Sharif , Nikolakopoulos George 
Published: March 2023

AbstractTime delays in communication networks are one of the main concerns in deploying robots with computation boards on the edge. This article proposes a multi-stage Nonlinear Model Predictive Control (NMPC) that is capable of handling varying network-induced time delays for establishing a control framework being able to guarantee collision-free Micro Aerial Vehicles (MAVs) navigation. This study introduces a novel approach that considers different sampling times by a tree of discretization scenarios contrary to the existing typical multi-stage NMPC where system uncertainties are modeled by a tree of scenarios. Additionally, the proposed method considers adaptive weights for the multi-stage NMPC scenarios based on the probability of time delays in the communication link. As a result of the multi-stage NMPC, the obtained optimal control action is valid for multiple sampling times. Finally, the overall effectiveness of the proposed novel control framework is demonstrated in various tests and different simulation environments.
Sex, Immigration, and Patterns of Access to Primary Care in Canada
Authors: Ssendikaddiwa Joseph M. , Goldenberg Shira , Berry Nicole S. , Lavergne M. Ruth 
Published: March 2023

AbstractAccess to primary care is crucial to immigrant health and may be shaped by sex and gender, but research is limited and inconclusive. We identified measures that reflect access to primary care using 2015–2018 Canadian Community Health Survey data. We used multivariable logistic regression models to estimate adjusted odds of primary care access and to explore interaction effects between sex and immigration group (recent immigrant: < 10 years in Canada, long-term immigrant: 10 + years, non-immigrant). Recency of immigration and being male were negatively associated with access to primary care, with significantly lower odds of having a usual place for immediate care among male recent immigrants (AOR: 0.36, 95% CI 032–0.42). Interaction effects between immigration and sex were pronounced, especially for having a regular provider or place of care. Results underscore the need to examine approachability and acceptability of primary care services, especially for male recent immigrants.
Evaluating the Feasibility of ChatGPT in Healthcare: An Analysis of Multiple Clinical and Research Scenarios
Authors: Cascella Marco , Montomoli Jonathan , Bellini Valentina , Bignami Elena 
Published: March 2023

AbstractThis paper aims to highlight the potential applications and limits of a large language model (LLM) in healthcare. ChatGPT is a recently developed LLM that was trained on a massive dataset of text for dialogue with users. Although AI-based language models like ChatGPT have demonstrated impressive capabilities, it is uncertain how well they will perform in real-world scenarios, particularly in fields such as medicine where high-level and complex thinking is necessary. Furthermore, while the use of ChatGPT in writing scientific articles and other scientific outputs may have potential benefits, important ethical concerns must also be addressed. Consequently, we investigated the feasibility of ChatGPT in clinical and research scenarios: (1) support of the clinical practice, (2) scientific production, (3) misuse in medicine and research, and (4) reasoning about public health topics. Results indicated that it is important to recognize and promote education on the appropriate use and potential pitfalls of AI-based LLMs in medicine.
Identifying sustainability priorities among value chain actors in artisanal common octopus fisheries
Authors: Ainsworth Gillian B. , Pita Pablo , Pita Cristina , Roumbedakis Katina , Pierce Graham J. , Longo Catherine , Verutes Gregory , Fonseca Tereza , Castelo Daniela , Montero-Castaño Carlos , Valeiras Julio , Rocha Francisco , García-de-la-Fuente Laura , Acuña Jose Luis , del Pino Fernández Rueda M. , Fabregat Alberto Garazo , Martín-Aristín Alberto , Villasante Sebastián 
Published: March 2023

AbstractThe United Nations (UN) Decade of Ocean Science highlights a need to improve the way in which scientific results effectively inform action and policies regarding the ocean. Our research contributes to achieving this goal by identifying practical actions, barriers, stakeholder contributions and resources required to increase the sustainability of activities carried out in the context of artisanal fisheries to meet UN Sustainable Development Goals (SDG) and International Year of Artisanal Fisheries and Aquaculture (IYAFA) Global Action Plan (GAP) Pillar targets. We conducted a novel ‘social value chain analysis’ via a participatory workshop to elicit perspectives of value chain actors and fisheries stakeholders associated with two Spanish artisanal common octopus (Octopus vulgaris) fisheries (western Asturias—Marine Stewardship Council [MSC] certified, and Galicia—non-MSC certified) about their priorities regarding sustainable octopus production and commercialization. Our adapted Rapfish sustainability framework emphasised the importance of economic, environmental, ethical, institutional, social, and technological indicators to different actors across the value chain. We mapped participants’ shared sustainability priorities (e.g. integrated fisheries management, knowledge-based management, product traceability) to six Rapfish indicators, seven IYAFA Pillars and twelve SDGs to reveal how our results can inform ocean policy and actions. This identified how certification incentives and other cooperative approaches can facilitate environmental, economic and social sustainability (e.g. value-added products, price premiums for producers, gender inclusive organisations); support IYAFA priority outcomes (raised awareness, strengthened science-policy interface, empowered stakeholders, partnerships); and help to achieve UN SDG targets (e.g. SDG 14.b, SDG 17.17). The results can inform actors, stakeholders and policymakers about how different actors contribute to efforts to achieve the SDGs and how to manage priorities for sustainable actions within artisanal fisheries and their value chains. We recommend inclusive and equitable participatory knowledge transfer and governance platforms as part of the UN Decade of Ocean Science and beyond where participants can create theories of change towards sustainability involving the development of multi-sectoral ocean policies framed at the level of the value chain and supported by appropriate governance structures.Graphical Abstract
Translocations of threatened plants in the Mediterranean Basin: current status and future directions
Authors: Fenu Giuseppe , Calderisi Giulia , Boršić Igor , Bou Dagher Kharrat Magda , García Fernández Alfredo , Kahale Rhea , Panitsa Maria , Cogoni Donatella 
Published: March 2023

AbstractThe Mediterranean Basin is one of the World’s plant diversity hotspots and a region prone to several anthropic pressures, besides being one of the World’s areas most susceptible to climate change. In this region, which hosts a high percentage of threatened species, there has been a large increase in practical conservation actions to prevent the extinction of many plants or improve their conservation status. In this framework, plant translocations have become increasingly important. To obtain a picture of the status and to depict possible directions, data on plant translocations was collected through the available databases, national experts, and the grey literature available online. Overall, a list of 836 translocations relating to 572 plant species was found. These actions are mainly concentrated in Spain, France, and Italy (c. 87%) and, except for some pioneering actions, translocations have strongly increased starting from 2010. A subsequent in-depth bibliographic search of the scientific databases was conducted to determine how much information about plant translocations was documented in the scientific literature. This search resulted in a list of 133 peer-reviewed papers, of which only 17 describing one or more translocations and, as a whole, reporting 101 experiences carried out on 56 plant species. Our research highlighted a great discrepancy between the scarce scientific documentation in comparison to the large number of practical conservation actions carried out. The great experience gained in these translocations constitutes an enormous heritage potentially available to implement the necessary conservation actions to preserve the plant diversity of the Mediterranean Basin.
Climate Change Risks on Mediterranean River Ecosystems and Adaptation Measures (Spain)
Authors: Estrela-Segrelles Clara , Gómez-Martínez Gabriel , Pérez-Martín Miguel Ángel 
Published: March 2023

AbstractThe Mediterranean is one of the most vulnerable regions to climate change impacts. Climate change scenarios predict that water temperature will increase up to 2.2–2.9ºC by the end of the century in Mediterranean rivers. This will cause an impact on water quality (oxygen dissolved reduction), reduce the available habitat of cold-water fish species and affect macroinvertebrates. Risk assessment methodology develops indicators that integrate hazard, exposure and vulnerability. Risk maps are key tools to prioritize the areas in which adaptation measures should be implemented in order to improve the adaptive capacity of ecosystems. The risk of habitat loss and ecosystem damage is very high in Mediterranean rivers. For RCP8.5, the 80% of the waterbodies that currently have brown trout presence are in High Risk (HR) or Very High Risk (VHR) of disappearing in the long term future (2070–2100) and the 35% in the short term (2010–2040). It will affect the middle sections first and the headwaters of the rivers later. The 92% of the waterbodies are in HR-VHR of macroinvertebrate family’s affection (2070–2100) and dissolved oxygen may be reduced by 0.5–0.75 mgO2/l (2070–2100). The restoration of the riverside vegetation is the main adaptation measure. This reduces significantly the stream temperature. Other measures are the groundwater protection and cold-water discharge from the reservoirs.
Selective accumulation of pharmaceutical residues from 6 different soils by plants: a comparative study on onion, radish, and spinach
Authors: Menacherry Sunil Paul M. , Kodešová Radka , Švecová Helena , Klement Aleš , Fér Miroslav , Nikodem Antonín , Grabic Roman 
Published: March 2023

Abstract
The accumulation of six pharmaceuticals of different therapeutic uses has been thoroughly investigated and compared between onion, spinach, and radish plants grown in six soil types. While neutral molecules (e.g., carbamazepine (CAR) and some of its metabolites) were efficiently accumulated and easily translocated to the plant leaves (onion > radish > spinach), the same for ionic (both anionic and cationic) molecules seems to be minor to moderate. The maximum accumulation of CAR crosses 38,000 (onion), 42,000 (radish), and 7000 (spinach) ng g−1 (dry weight) respectively, in which the most majority of them happened within the plant leaves. Among the metabolites, the accumulation of carbamazepine 10,11-epoxide (EPC — a primary CAR metabolite) was approximately 19,000 (onion), 7000 (radish), and 6000 (spinach) ng g−1 (dry weight) respectively. This trend was considerably similar even when all these pharmaceuticals applied together. The accumulation of most other molecules (e.g., citalopram, clindamycin, clindamycin sulfoxide, fexofenadine, irbesartan, and sulfamethoxazole) was restricted to plant roots, except for certain cases (e.g., clindamycin and clindamycin sulfoxide in onion leaves). Our results clearly demonstrated the potential role of this accumulation process on the entrance of pharmaceuticals/metabolites into the food chain, which eventually becomes a threat to associated living biota.
Special issue “reflecting on Freire: a praxis of radical love and critical hope for science education”—theme: transnational collaborations and solidarities
Authors: Gandolfi Haira 
Published: March 2023

AbstractIn this article I will examine some of the issues raised by the following three articles in this special issue about Paulo Freire and science education: Jenny Tilsen’s “The freshness of irreverence”: learning from ACT UP towards socio-political action in science education”; Suzani Cassiani and Irlan von Linsingen’s “Freirean inspirations in solidary internationalism between East Timor and Brazil in science education”; and Gonzalo Peñalosa, Jairo Robles-Piñeros and Geilsa Costa Santos Baptista’s “Science Education and Cultural Diversity: Freire’s Concept of Dialogue as Theoretical Lens to Study the Classroom Discourse of Science Teachers”. Brought together within this special issue under the theme of Transnational collaborations and solidarities, these articles explore the possibilities and tensions that emerge from thinking and practicing a Freirean-inspired science education that enables socio-political action and transformation by marginalised communities across the world. In this review, I will focus on ideas raised (to different extents) across these articles around three interrelated areas—interculturality and decoloniality, socio-political transformation, and teacher education and work—with the aim of expanding on what transnational inspirations and collaborations such as the ones promoted by this special issue can mean to those of us across the world working against the grain of marginalisation and dehumanisation (of students and teachers) from within science education.
Dynamic causal modeling analysis reveals the modulation of motor cortex and integration in superior temporal gyrus during multisensory speech perception
Authors: Zou Ting , Li Liyuan , Huang Xinju , Deng Chijun , Wang Xuyang , Gao Qing , Chen Huafu , Li Rong 
Published: March 2023

AbstractThe processing of speech information from various sensory modalities is crucial for human communication. Both left posterior superior temporal gyrus (pSTG) and motor cortex importantly involve in the multisensory speech perception. However, the dynamic integration of primary sensory regions to pSTG and the motor cortex remain unclear. Here, we implemented a behavioral experiment of classical McGurk effect paradigm and acquired the task functional magnetic resonance imaging (fMRI) data during synchronized audiovisual syllabic perception from 63 normal adults. We conducted dynamic causal modeling (DCM) analysis to explore the cross-modal interactions among the left pSTG, left precentral gyrus (PrG), left middle superior temporal gyrus (mSTG), and left fusiform gyrus (FuG). Bayesian model selection favored a winning model that included modulations of connections to PrG (mSTG → PrG, FuG → PrG), from PrG (PrG → mSTG, PrG → FuG), and to pSTG (mSTG → pSTG, FuG → pSTG). Moreover, the coupling strength of the above connections correlated with behavioral McGurk susceptibility. In addition, significant differences were found in the coupling strength of these connections between strong and weak McGurk perceivers. Strong perceivers modulated less inhibitory visual influence, allowed less excitatory auditory information flowing into PrG, but integrated more audiovisual information in pSTG. Taken together, our findings show that the PrG and pSTG interact dynamically with primary cortices during audiovisual speech, and support the motor cortex plays a specifically functional role in modulating the gain and salience between auditory and visual modalities.
Key Targets and Molecular Mechanisms of the Fat-soluble Components of Ginseng for Lung Cancer Treatment
Authors: Gao Dongdong , Li Yingyue , Xiang Sen , Zhang Jing 
Published: March 2023

AbstractObjective: To analyze the regulatory effects and key targets of the fat-soluble components of ginseng in lung cancer. Methods: Gas chromatography–mass spectrometry and the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform were used to analyze and identify the fat-soluble components of ginseng. Network pharmacology was used to analyze the therapeutic targets of the fat-soluble components of ginseng in lung cancer and screen key proteins. In vitro assays were conducted to verify the effects of the active fat-soluble components of ginseng on proliferation and apoptosis in lung cancer cells and to verify the regulation of key proteins. Results: Ten active fat-soluble components of ginseng were screened for follow-up. Network pharmacology showed 33 overlapping targets between the active fat-soluble components of ginseng and lung cancer, and functional enrichment of the targets showed involvement of response to nitrogen, hormone response, membrane raft, and positive regulation of external stimulus. Pathway enrichment analysis showed vascular endothelial growth factor (VEGF) signaling, adipocyte lipolysis regulation, chronic myelogenous leukemia, endocrine resistance, and NSCLC-related pathways. A protein-protein interaction network was constructed, and the top 10 targets were selected in accordance with their scores. Ultimately, five target genes (EGFR, KDR, MAPK3, PTPN11, and CTNNB1) were selected in combination with literature mining for subsequent experimental verification. Proliferation assays showed that the growth of lung cancer cells was significantly decreased in a concentration-dependent manner in the fat-soluble components of ginseng intervention group compared with controls. Flow cytometry showed that active fat-soluble components of ginseng promoted apoptosis in a concentration-dependent manner in lung cancer cells. Western blot and quantitative real-time PCR showed that levels of the five key proteins and mRNAs were significantly decreased in the intervention group; furthermore, histone protein and mRNA levels were significantly higher in the high-concentration intervention group compared with the low-concentration group. Conclusion: The active fat-soluble components of ginseng inhibited the growth of lung cancer cells and promoted apoptosis. The underlying regulatory mechanisms may be related to signaling pathways involving EGFR, KDR, MAPK3, PTPN11, and CTNNB1.
Human Amniotic Mesenchymal Stem Cells Alleviate aGVHD after allo-HSCT by Regulating Interactions between Gut Microbiota and Intestinal Immunity
Authors: Bu Xiaoyin , Wang Junhui , Yin Zhao , Pan Weifeng , Liu Liping , Jin Hua , Liu Qifa , Zheng Lei , Sun Haitao , Gao Ya , Ping Baohong 
Published: March 2023

Abstract
Acute graft-versus-host disease (aGVHD) after allogeneic hematopoietic stem cell transplantation poses one of the most vexing challenges. Gut microbiota dysbiosis can proceed aGVHD and mesenchymal stem cells (MSCs) have promising therapeutic potential for aGVHD. However, whether hAMSCs affect the gut microbiota during aGVHD mitigation remains unknown. Accordingly, we sought to define the effects and underlying mechanisms of human amniotic membrane-derived MSCs (hAMSCs) regulating the gut microbiota and intestinal immunity in aGVHD. By establishing humanized aGVHD mouse models and hAMSCs treatment, we found that hAMSCs significantly ameliorated aGVHD symptoms, reversed the immune imbalance of T cell subsets and cytokines, and restored intestinal barrier. Moreover, the diversity and composition of gut microbiota were improved upon treatment with hAMSCs. Spearman’s correlation analysis showed that there was a correlation between the gut microbiota and tight junction proteins, immune cells as well as cytokines. Our research suggested that hAMSCs alleviated aGVHD by promoting gut microbiota normalization and regulating the interactions between the gut microbiota and intestinal barrier, immunity.
Graphical Abstract
Nanospanlastics as a Novel Approach for Improving the Oral Delivery of Resveratrol in Lipopolysaccharide-Induced Endotoxicity in Mice
Authors: Younis Mostafa Mohamed , Fadel Noha Abd El-Fattah , Darwish Asmaa Badawy , Mohsen Amira Mohamed 
Published: March 2023

Abstract
Purpose
Resveratrol (RSV) is a natural polyphenolic compound that has numerous biological effects. Owing to its poor bioavailability, only trace concentrations of RSV could be found at the site of action. Therefore, the present study was aimed at developing RSV-loaded nanospanlastics to improve its oral delivery and therapeutic activity.

Methods
RSV-loaded nanospanlastics were prepared using the thin film hydration technique. The developed formulations were characterized via vesicular size (VS), polydispersity index (PDI), zeta potential (ZP) measurements, fourier transform infrared (FT-IR) spectroscopy analysis and transmission electron microscopy (TEM). In vitro release profile was carried out using dialysis bag diffusion technique. In vivo study was carried out using lipopolysaccharide (LPS)-induced endotoxicity model in mice to evaluate the formulations activity.

Results
The results revealed the successful development of RSV-loaded nanospanlastics which exhibited EE% ranging from 45 to 85%, particle sizes ranging from 260.5 to 794.3 nm; negatively charged zeta potential (≤ − 20 mV) and TEM revealed their spherical shape. An in vitro release study showed biphasic pattern with sustained release of drug up to 24 h. In vivo results showed the superiority of RSV-loaded nanospanlastics over conventional niosomes in attenuating serum levels of liver and kidney functions (aspartate transaminase (AST), alanine transaminase (ALT), and creatinine) in LPS-induced endotoxic mice. Furthermore, both of them suppressed the elevated oxidative stress and inflammatory markers (malondialdehyde (MDA), nitric oxide (NO), and interleukin-1beta (IL-1β)) estimated in the liver and kidney tissues. However, the nanospanlastics showed a prevalence effect over conventional niosomes in kidney measurements and the histopathological examinations.

Conclusions
These findings reveal the potential of nanospanlastics in improving the oral delivery and therapeutic efficacy of RSV.