bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Arabidopsis eIF4E1 regulates NRT1.1‐mediated nitrate signaling at both translational and transcriptional levels
Authors: Li Na , Duan Yawen , Ye Qing , Ma Yuhan , Ma Rongjie , Zhao Lufei , Zhu Sirui , Yu Feng , Qi Shengdong , Wang Yong 
Published: July 2023

Summary
Identifying new nitrate regulatory genes and illustrating their mechanisms in modulating nitrate signaling are of great significance for achieving the high yield and nitrogen use efficiency (NUE) of crops.
Here, we screened a mutant with defects in nitrate response and mapped the mutation to the gene eIF4E1 in Arabidopsis. Our results showed that eIF4E1 regulated nitrate signaling and metabolism. Ribo‐seq and polysome profiling analysis revealed that eIF4E1 modulated the amount of some nitrogen (N)‐related mRNAs being translated, especially the mRNA of NRT1.1 was reduced in the eif4e1 mutant.
RNA‐Seq results enriched some N‐related genes, supporting that eIF4E1 is involved in nitrate regulation. The genetic analysis indicated that eIF4E1 worked upstream of NRT1.1 in nitrate signaling. In addition, an eIF4E1‐interacting protein GEMIN2 was identified and found to be involved in nitrate signaling. Further investigation showed that overexpression of eIF4E1 promoted plant growth and enhanced yield and NUE.
These results demonstrate that eIF4E1 regulates nitrate signaling by modulating NRT1.1 at both translational and transcriptional levels, laying the foundation for future research on the regulation of mineral nutrition at the translational level.
ZEB1 interferes with human periodontal ligament stem cell proliferation and differentiation
Authors: Qian Liwen , Ni Jing , Zhang Zhechen 
Published: July 2023

AbstractBackgroundPeriodontitis can eventually contribute to tooth loss. Zinc finger E‐box binding homeobox 1 (ZEB1) is identified as overexpressed in the gingival tissue of mice with periodontitis. This study is designed to decipher the mechanism of ZEB1's involvement in periodontitis.MethodsHuman periodontal mesenchymal stem cells (hPDLSCs) were exposed to LPS to mimic the inflammation in periodontitis. Following ZEB1 silencing, FX1 (an inhibitor of Bcl‐6) treatment or ROCK1 overexpression, cell viability, and apoptosis were analyzed. Alkaline phosphatase (ALP) staining, Alizarin red staining, RT‐qPCR, and western blot were performed to evaluate osteogenic differentiation and mineralization. hPDLSCs were processed for luciferase reporter assay and ChIP‐PCR to confirm the association between ZEB1 and ROCK1.ResultsThe induction of ZEB1 silencing resulted in reduced cell apoptosis, enhanced osteogenic differentiation, and mineralization. Nevertheless, these effects were significantly blunted by FX1. ZEB1 was confirmed to bind to the promoter sites of ROCK1 and regulate the ROCK1/AMPK. Whereas ROCK1 overexpression reversed the effects of ZEB1 silencing on Bcl‐6/STAT1, as well as cell proliferation and osteogenesis differentiation.ConclusionhPDLSCs displayed decreased proliferation and weakened osteogenesis differentiation in response to LPS. These impacts were mediated by ZEB1 regulating Bcl‐6/STAT1 via AMPK/ROCK1.
Dexmedetomidine versus fentanyl for sedation in extremely preterm infants
Authors: Nakauchi Chiharuko , Miyata Masafumi , Kamino Shigemitsu , Funato Yusuke , Manabe Masahiko , Kojima Arisa , Kawai Yuri , Uchida Hidetoshi , Fujino Masayuki , Boda Hiroko 
Published: July 2023

AbstractBackgroundFew studies have compared the efficacy and complications of dexmedetomidine (DEX) and fentanyl (FEN) in extremely preterm infants.MethodsWe conducted a single‐institution, retrospective controlled before and after study of preterm infants before 28 weeks of gestation admitted between April 2010 and December 2018 to compare the complications and efficacy of DEX and FEN for preterm infants. Patients were administered FEN prior to 2015 and DEX after 2015 as the first‐line sedative. A composite outcome of death during hospitalization and developmental quotient (DQ) < 70 at a corrected age of 3 years was compared as the primary outcome. Secondary outcomes including postmenstrual weeks at extubation, days of age when full enteral feeding was achieved and additional sedation by phenobarbital (PB) were compared.ResultsSixty‐six infants were enrolled into the study. The only perinatal factor that differed between the FEN (n = 33) and DEX (n = 33) groups was weeks of gestation. The composite outcome of death and DQ < 70 at a corrected age of 3 years were not significantly different. Postmenstrual weeks at extubation did not significantly differ between groups after adjustment for weeks of gestation and being small for gestational age. On the other hand, full feeding was significantly prolonged by DEX (p = 0.031). Additional sedation was less common in the DEX group (p = 0.044).ConclusionThe composite outcome of death and DQ < 70 at a corrected age of 3 years were not significantly different by DEX or FEN for primary sedation. Prospective randomized controlled trials should examine the long‐term effects on development.
Multi-Furcation Variations of Two Novel Double-Centered Mechanisms Based on Higher Order Kinematic Analyses and Singular Value Decomposition
Authors: Tang Zhao , Dai Jian S. 
Published: July 2023

Abstract
This paper explores a class of extended double-centered linkages and presents two novel multi-bifurcated double-centered metamorphic and reconfigurable mechanisms. Higher order kinematic analyses and singular value decomposition are combined to demonstrate the characteristics of multi-furcation and to reveal motion branch transformation. These findings show that the presented double-centered linkages are able to evolve to distinct motion branches including two spherical 4R linkages, line-symmetric Bricard linkage or Bennett linkage. Furthermore, by exploring the local properties of singular configurations on geometric constraints and algebraic relationships, a systematic approach for the synthesis of the singular configurations can be designed to discover more novel multi-bifurcated metamorphic and reconfigurable mechanisms.
Value of a UK medical degree for international students (VISION): a cross-sectional study
Authors: Li Chun Hei , Ganesananthan Sashiananthan , Pinchemain Trevor , Godoi Amanda , Lim Shan Ming , Baskaran Ravanth , Mukhopadhyay Srinjay , Foo Eu Fang , Ooi Setthasorn Zhi Yang , Woo Timothy , Yeo Vanessa ,   VISION collaborators, Sweetland Helen 
Published: July 2023

ObjectivesIt is estimated that NHS staff consist of over 200 different nationalities, with a reported 30.7% of doctors holding a nationality other than British. Despite this, international medical students represent 7.5% of all medical students studying in the UK and pay on average, 4–6 times more in tuition fees when compared with the £9250 per annum (Great British Pounds (£) in 2021) paid by home students. This study’s aim and objective are to evaluate the perception of the financial cost and value of the UK medical degree for international students and their motivations for pursuing such a degree.MethodsThis is a cross-sectional observational study enquiring about international premedical, medical and medical school graduates’ perception of the value of the UK medical degree and factors influencing their decision to study in the UK.A questionnaire was developed and distributed to 24 medical schools and 64 secondary schools both internationally and across the UK.ResultsA total of 352 responses from 56 nationalities were recorded. 96% of international students identified clinical and academic opportunities as the most important factors to study medicine in the UK, closely followed by quality of life (88%). The least important factor was family reasons, with 39% of individuals identifying this factor. Only 4.82% of graduates in our study considered leaving the UK after training. Overall, 54% of students felt the UK degree was value for money. This belief was significantly higher in premedical students compared with existing students and graduates (71% vs 52% and 20%, p<0.001 for all comparisons).ConclusionThe quality of medical education and international prestige are attractive factors for international students to study medicine in the UK. However, further work is needed to ascertain reasons for the differing perceptions of the value by international students at different stages in their clinical training.
Does value-based healthcare support patient-centred care? A scoping review of the evidence
Authors: Kidanemariam Martha , Pieterse Arwen H , van Staalduinen Dorine J , Bos Willem Jan W , Stiggelbout Anne M 
Published: July 2023

BackgroundStandardisation of outcome measures is integral to value-based healthcare (VBHC), which may conflict with patient-centred care, focusing on personalisation.ObjectivesWe aimed to provide an overview of measures used to assess the effect of VBHC implementation and to examine to what extent the evidence indicates that VBHC supports patient-centred care.DesignA scoping review guided by the Joanna Briggs Institute methodology.Sources of evidenceWe searched the following databases on 18 February 2021: Cochrane Library, EMBASE, MEDLINE and Web of Science.Eligibility criteriaWe included empirical papers assessing the effect of the implementation of VBHC, published after introduction of VBHC in 2006.Data extraction and synthesisTwo independent reviewers double-screened papers and data were extracted by one reviewer and checked by the other. We classified the study measures used in included papers into six categories: process indicator, cost measure, clinical outcome, patient-reported outcome, patient-reported experience or clinician-reported experience. We then assessed the patient-centredness of the study measures used.ResultsWe included 39 studies using 94 unique study measures. The most frequently used study measures (n=72) were process indicators, cost measures and clinical outcomes, which rarely were patient-centred. The less frequently used (n=20) patient-reported outcome and experience measures often measured a dimension of patient-centred care.ConclusionOur study shows that the evidence on VBHC supporting patient-centred care is limited, exposing a knowledge gap in VBHC research. The most frequently used study measures in VBHC research are not patient-centred. The major focus seems to be on measures of quality of care defined from a provider, institution or payer perspective.
Cortisol dynamics in undergraduate nursing students during clinical practice: protocol for an exploratory cross-sectional study
Authors: Loureiro Fernanda , Família Carlos , Barroso Maria Helena , Baúto Ricardo Ventura , Antunes A. Vanessa 
Published: July 2023

IntroductionThis paper presents a protocol for the Investigation of Cortisol Dynamics in Undergraduate Nursing Students, a funded project aiming to understand the fluctuations in anxiety and salivary cortisol levels due to clinical setting changes and the anxiety associated with clinical practice.Methods and analysisThis study is an exploratory, cross-sectional, observational study that will be conducted at a health and science school in Portugal. Data collection will involve phycological assessment instruments for personality, anxiety, stress, depression and saliva cortisol levels. The target population consists of undergraduate nursing students enrolled in our institution for the academic year of 2022/2023 (N=272), of whom we aim to recruit 35% (N=96) to the study.Ethics and disseminationThe project obtained approval from the Institutional Review Board of the Egas Moniz—Cooperativa de Ensino Superior, CRL, on 5 July 2022 (ID: 116/21.22) and ethical approval from the Egas Moniz Ethics Committee on 28 July 2022 (ID:1110.22). Informed consent will be obtained from those who wish to participate, ensuring students’ voluntary participation in the project. The results of this study will be disseminated through open-access peer-reviewed publications and presented at scientific events.
Effectiveness of physical exercise programmes in reducing complications associated with secondary lymphoedema to breast cancer: a protocol for an overview of systematic reviews
Authors: Aguilera-Eguía Raúl Alberto , Gutiérrez-Arias Ruvistay , Zaror Carlos , Seron Pamela 
Published: July 2023

IntroductionBreast cancer-related lymphoedema (BCRL) is one of the most underestimated and debilitating complications associated with the treatment that women with breast cancer receive. Several systematic reviews (SRs) of different physical exercise programmes have been published, presenting disperse and contradictory clinical results. Therefore, there is a need for access to the best available and summarised evidence to capture and evaluate all the physical exercise programmes that focus on reducing BCRL.ObjectiveTo evaluate the effectiveness of different physical exercise programmes in reducing the volume of lymphoedema, pain intensity and improving quality of life.Method and analysisThe protocol of this overview is reported following the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols, and its methodology is based on Cochrane Handbook for Systematic Reviews of Interventions. Only those SRs involving physical exercise by patients with BCRL will be included, whether on its own or combined with other exercises or other physical therapy interventions.The outcomes of interest to be considered will be lymphoedema volume, quality of life, pain intensity, grip strength, range of motion, upper limb function and any adverse event. The MEDLINE/PubMed, Lilacs, Cochrane Library, PEDro and Embase databases will be searched for reports published from database inception to April 2023.Two researchers will perform study selection, data extraction and risk of bias assessment independently. Any discrepancy will be resolved by consensus, or ultimately, by a third-party reviewer. We will use Grading of Recommendations Assessment, Development and Evaluation System to assess the overall quality of the body of evidence.Ethics and disseminationThe results of this overview will be published in peer-reviewed scholarly journals and the scientific dissemination will take place in national or international conferences. This study does not require approval from an ethics committee, as it does not directly collect information from patients.PROSPERO registration numberCRD42022334433.
Increasing utilisation of a rebound hyperbilirubinaemia calculator in two newborn nurseries
Authors: Germana Sarah , Shaikh Sophie Kay 
Published: July 2023

Neonatal hyperbilirubinaemia requiring phototherapy treatment is a common problem impacting the length of hospital stay and rates of hospital readmission. Previous guidelines included guidance for initiating phototherapy treatment but not for discontinuing phototherapy treatment during initial newborn admission.In response to dissatisfaction from trainees, staff and families regarding the variable approach to discontinuing phototherapy among attending nursery providers, we used quality improvement methodologies to increase utilisation of a rebound hyperbilirubinaemia calculator as a more consistent method for guiding the timing of phototherapy discontinuation. The aim was to increase utilisation of the rebound hyperbilirubinaemia calculator for newborns treated with phototherapy in two newborn nurseries to >90% within 2 years.Sequential interventions focused on increasing provider awareness of the rebound hyperbilirubinaemia calculator and making the calculator simple to access and use.At the university medical centre nursery, the use of the calculator increased from 8.7% to 100%, exceeding the project goal. In the community hospital nursery, there was a statistically significant increase in the rate of utilisation from 3.7% to 79.4%, but this fell slightly below the goal of >90%.Electronic Health Record integration, along with education and addition of prompts to providers, increased utilisation of a rebound hyperbilirubinaemia calculator as a consistent approach for guiding decisions about discontinuing phototherapy treatment in newborns.
Suppression of spin polarization as an indicator of QCD critical point
Authors: Singh Sushant K. , Alam Jane 
Published: July 2023

AbstractWe study the impact of the QCD critical point (CP) on the spin polarization of $$\Lambda $$
Λ
-hyperon generated by the thermal vorticity in viscous quark gluon plasma (QGP). The equations of the relativistic causal viscous hydrodynamics have been solved numerically in (3+1) dimensions to evaluate the thermal vorticity. The effects of the CP have been incorporated through the equation of state (EoS) and the scaling behavior of the transport coefficients. We observe a significant suppression of the spin polarization around mid-rapidity region induced by the CP and propose that such changed behaviour of the spin polarization can be used to detect the CP. To the best of our knowledge this is the first study on the effects of critical point on the spin polarization in QCD matter.
Data from The MDM2–p53 Antagonist Brigimadlin (BI 907828) in Patients with Advanced or Metastatic Solid Tumors: Results of a Phase Ia, First-in-Human, Dose-Escalation Study
Authors: LoRusso Patricia , Yamamoto Noboru , Patel Manish R. , Laurie Scott A. , Bauer Todd M. , Geng Junxian , Davenport Teffany , Teufel Michael , Li Jian , Lahmar Mehdi , Gounder Mrinal M. 
Published: July 2023

<div>Abstract<p><b>Brigimadlin (BI 907828)</b> is an oral MDM2–p53 antagonist that has shown encouraging antitumor activity <i>in vivo</i>. We present phase Ia results from an open-label, first-in-human, phase Ia/Ib study investigating brigimadlin in patients with advanced solid tumors (NCT03449381). Fifty-four patients received escalating doses of brigimadlin on day 1 of 21-day cycles (D1q3w) or days 1 and 8 of 28-day cycles (D1D8q4w). Based on dose-limiting toxicities during cycle 1, the maximum tolerated dose was selected as 60 mg for D1q3w and 45 mg for D1D8q4w. The most common treatment-related adverse events (TRAE) were nausea (74.1%) and vomiting (51.9%); the most common grade ≥3 TRAEs were thrombocytopenia (25.9%) and neutropenia (24.1%). As evidence of target engagement, time- and dose-dependent increases in growth differentiation factor 15 levels were seen. Preliminary efficacy was encouraging (11.1% overall response and 74.1% disease control rates), particularly in patients with well-differentiated or dedifferentiated liposarcoma (100% and 75% disease control rates, respectively).</p>Significance:<p>We report phase Ia data indicating that the oral MDM2–p53 antagonist brigimadlin has a manageable safety profile and shows encouraging signs of efficacy in patients with solid tumors, particularly those with <i>MDM2</i>-amplified advanced/metastatic well-differentiated or dedifferentiated liposarcoma. Further clinical investigation of brigimadlin is ongoing.</p></div>
Quantitative and Qualitative Exploration of the Effect of a Wearable Item on Non-Organic Virtual Limb Embodiment and User Behavior in Immersive Environments
Authors: Gorisse Geoffrey , Brousse Audrey , Richir Simon , Christmann Olivier 
Published: July 2023

Abstract
This experiment was designed to investigate the potential contribution to the sense of embodiment of a wristband worn by the participants in both real and virtual environments. In addition, two virtual limb models were compared following a mixed between-within subjects design: an organic hand and a non-organic prosthesis matching the proposed task. Quantitative results revealed no significant effect of the wristband, while post-experiment semistructured interviews revealed that the wristband fostered the identification with the virtual limbs for several participants, but that it might be conditioned by interindividual differences. Ownership scores were significantly higher with the virtual hand. However, participants experienced a very high sense of agency with both conditions despite the lack of finger tracking when controlling the prosthesis. Agency was positively correlated with participants' perceived change in their body schema when embodying the prosthesis. Subjective and objective measures demonstrated that participants were less hesitant and that more collisions were recorded at higher speeds against potentially threatening objects with the non-organic prosthesis.
Intermodel Biases of the Western North Pacific Monsoon Trough in CMIP6 Models
Authors: Feng Xiaofang , Wu Liguang , Wang Chao 
Published: July 2023

Abstract
The impact of climate change on tropical cyclone (TC) activity is often assessed by various downscaling approaches, statistical–dynamical frameworks, and high-resolution global climate models using the projected changes of environmental factors. Uncertainty in simulating and projecting TC-relevant, large-scale circulation is closely linked to the projection of TC activity in a warming climate. Based on the model output in phase 6 of the Coupled Model Intercomparison Project (CMIP6), this study examines the intermodel biases in simulating the western North Pacific monsoon trough (MT), which is one of the most important large-scale circulation systems for TC activity, especially TC formation. It is found that most CMIP6 models can successfully simulate the climatological mean structure of the MT, although considerable biases remain in its exact location and its simulated historical changes. The mean latitude of the simulated MT spreads between 10° and 20°N, with noticeable differences in its orientation. The multimodel ensemble mean indicates that the MT exhibits no significant long-term zonal and poleward shifts in the future scenarios, consistent with the projection in the selected models in which the simulated MT resembles the observed spatiotemporal characteristics of the counterpart. Further analysis suggests that the intermodel bias in the simulated MT location is closely related to the east–west contrast of sea surface temperature (SST) anomalies in the tropical Pacific. More attention is required on improving the simulation of the basinwide SST distribution and its associated MT to reduce the uncertainty in predicting the future location of TC formation.
Benchmarking the Observed Best Predictor
Authors: Bandyopadhyay Rohosen , Jiang Jiming 
Published: July 2023

We propose two methods for benchmarking the observed best predictor (OBP; Jiang et al.[ 1 ]) in small area estimation under the Fay-Herriot model. Furthermore, we propose two methods for estimating the mean squared prediction error (MSPE) of the benchmarked OBP. Theoretical and empirical properties of the benchmarked OBP as well as its MSPE estimators are studied. A real-data example is considered. AMS Subject Classification: 62J05