bluuebunny/crossref_metadata_2025_split huggingface dataset:
You gotta walk the walk to talk the talk: protocol for a feasibility study of the Happy Older Latino Adults (HOLA) health promotion intervention for older HIV-positive Latino men
Authors: Jimenez Daniel E. , Weinstein Elliott R. , Batsis John 
Published: March 2023

Abstract
Background
Older Latinos living with the human immunodeficiency virus (HIV) have been disproportionately affected by the epidemic and experience compounded health disparities that have deepened over time. These health disparities are largely related to lifestyle and are either preventable or amenable to early detection or intervention. Despite existing resources to deliver an intervention to reduce this compounded health disparity, there is little information on the effects of health promotion interventions on indices of cardiometabolic risk in midlife and older Latinos living with HIV. The Happy Older Latinos are Active (HOLA) intervention is an innovative health promotion program that is uniquely tailored to meet the diverse needs and circumstances of older Latinos with HIV. The goal of this manuscript is to describe the protocol of a feasibility study of the HOLA health promotion intervention for older HIV-positive Latino men.

Methods/design
HOLA, which is informed by Behavioral Activation and Social Learning theory is a community health worker (CHW)-led, multicomponent, health promotion intervention consisting of: (1) a social and physical activation session; (2) a moderately intense group walk led by a CHW for 45 min, 3×/week for 16 weeks; (3) pleasant events (e.g., going to brunch with friends) scheduling. Eighteen community dwelling Latinos living with HIV aged 50+ will be recruited for this feasibility study adapting the HOLA intervention. Participants will be assessed at three time points (baseline, post-intervention, and 3 months post-intervention) on measures of cardiometabolic risk factors (waist circumference, dyslipidemia, hypertension, and glucose), psychosocial functioning, and health-related quality of life.

Conclusions
If HOLA can be delivered successfully by CHWs, then the scalability, accessibility, and potential for dissemination is increased. Additionally, this study will inform feasibility and identify modifications needed in the design of a larger hypothesis testing study.

Trial registration
Clinicaltrials.gov Identifier: NCT 03839212. Date of Registration: 8 February, 2019.
Understanding the adoption context of China’s digital currency electronic payment
Authors: Xia Huosong , Gao Yangmei , Zhang Justin Zuopeng 
Published: March 2023

AbstractCentral banks worldwide have started researching and developing central bank digital currencies (CBDCs). In the digital economy context, concerns regarding the integrity, competition, and privacy of CBDC systems have also gradually emerged. Against this backdrop, this study aims to evaluate users’ willingness to use China’s digital currency electronic payment (DCEP) system, a digital payment and processing network, and its influencing factors by comprehensively considering and comparing the characteristics of cash and third-party payment services. Combining the push-pull-mooring framework (PPM) and task-technology fit (TTF) theory, we discuss the scenarios and mechanisms that may inspire users’ DCEP adoption intention through an empirical study. The results reveal that privacy concerns regarding the original payment methods and technology-task fitting level of DCEP positively impact users’ willingness to adopt DCEP. The technical characteristics of DCEP, users’ payment requirements, and government support positively affect users’ adoption intention by influencing the task-technology fitting degree of DCEP. Switching cost significantly and negatively impacts adoption intention, whereas relative advantage exhibits no significant effect. This research contributes to a better understanding of the factors that influence switching intentions and the actual use of DCEP, and provides policy guidance on promoting the efficiency and effectiveness of DCEP.
Associated systemic diseases and etiologies of medication-related osteonecrosis of the jaw: a retrospective study of 265 surgical cases
Authors: Chang Hoon-Je , Kim Min-Jae , Ahn Kang-Min 
Published: March 2023

Abstract
Background
Medication-related osteonecrosis of the jaw (MRONJ) is one of the complications caused by various drugs. As there are increasing reports of MRONJ, it is important to diagnose and identify patients who have the potential risk of the disease. The aim of this study was to analyze the systemic diseases, etiology, and treatment results of MRONJ.

Material and methods
A total of 265 MRONJ operations were reviewed retrospectively. This study included patients who were diagnosed as MRONJ and those who also received surgery, ranging from simple extraction to reconstruction with free flaps, from 2009 to 2021. Each patient’s systemic disease and eitology and basic demographic information was taken into consideration.

Results
The most common diseases related were osteoporosis (n = 127), breast cancer (n = 77), multiple myeloma (n = 27), prostate cancer (n = 26), and etc. (n = 12). The related causes of MRONJ were extraction (n = 138), implants (n = 40), and irritations by prosthesis (n = 29); however, 55 cases were occurred spontaneously. Out of 265 patients, 214 were women while 51 were men. The average age when the surgery took place was 67.7 and 69.8 years for male and female patients, respectively. Saucerization and sequestrectomy (n = 252) was the most common surgical treatment, followed by mandibulectomy (n = 12) and partial maxillectomy (n = 1). While 4 cases occurred in both jaws, 168 cases were in the mandible and 93 cases were in the maxilla.

Conclusion
Nearly 50 % of the MRONJ patients had osteoporosis and the other patients who received bone targeting agents parentral had bone metastasis of various cancers. Extraction is the most common related event for MRONJ.
The association of preoperative high-sensitivity cardiac troponin i and long-term outcomes in colorectal cancer patients received tumor resection surgery
Authors: Zhang Yitao , Huang Zicheng , Hu Sutian , Si Jinhong , Cheng Shiyao , Chen Zhichong , Xue Jiaojie , Lou Xue , Peng Huajing , Li Zequan , Ouyang Mao , Gao Xiang , Zeng Weijie 
Published: March 2023

Abstract
Background
This study aimed to evaluate the association between preoperative hs-cTnI and long-term mortality and major adverse cardiovascular events (MACE) in colorectal cancer patients.

Methods
This single-center retrospective cohort study included 1105 consecutive colorectal cancer patients who received tumor resection surgery between January 2018 and June 2020. Inclusion criteria were an age ≥ 18 years and had been tested for hs-cTnI on admission within 7 days prior to tumor resection surgery. Exclusion criteria were emergent surgery, failure to received tumor resection surgery, hospital death, there was clinical evidence of unstable coronary artery disease or pulmonary embolism occurred before operation according to medical record. The primary endpoint was all-cause death. Secondary endpoint was major adverse cardiovascular events (MACE).

Results
A total of 1105 patients were enrolled: 1032 with normal hs-cTnI and 73 with elevated hs-cTnI. The mean follow-up was 24.4 ± 10.8 months, 176 patients died and 39 patients met MACE. In the elevated troponin group, 50%, 32.1% and 17.9% died from cancer, cardiovascular and other causes, while those in the normal troponin group were 75.7%, 2% and 22.3%, there was statistical difference between 2 groups (P < 0.001). Patients with elevated preoperative hs-cTnI had significantly higher mortality (P < 0.001) and more MACE (P < 0.001) compared with those with normal hs-cTnI. A propensity-matching analysis were performed, resulting in 151 patients with normal hs-cTnI and 60 patients with elevated hs-cTnI. The matched population had the similar results for all-cause death (P = 0.009) and MACE (P = 0.001). The results were consistent after further excluding 147 patients who had received chemoradiotherapy prior to surgery in subgroup analysis. The results of multivariate Cox regression analysis shown that hs-cTnI was one of the best predictors for all-cause death (hazard ratio [HR] 2.278; 95% confidence interval [CI] 1.19–4.361) and MACE (HR, 3.523; 95%CI, 1.477–8.403) in total populations, similar results were found in subgroup analysis.

Conclusions
Colorectal cancer patients without myocardial ischemia manifestation but with elevated hs-cTnI prior to tumor resection surgery were at increased risk for long-term all-cause death and MACE, irrespective of whether they have received chemoradiotherapy prior to surgery.
Accessing and utilizing clinical and genomic data from an electronic health record data warehouse
Authors: Arnold Cosby G. , Sonn Brandon , Meyers Frederick J. , Vest Alexis , Puls Richie , Zirkler Estelle , Edelmann Michelle , Brooks Ian M. , Monte Andrew A. 
Published: March 2023

AbstractElectronic health records (EHRs) and linked biobanks have tremendous potential to advance biomedical research and ultimately improve the health of future generations. Repurposing EHR data for research is not without challenges, however. In this paper, we describe the processes and considerations necessary to successfully access and utilize a data warehouse for research. Although imperfect, data warehouses are a powerful tool for harnessing a large amount of data to phenotype disease. They will have increasing relevance and applications in clinical research with growing sophistication in processes for EHR data abstraction, biobank integration, and cross-institutional linkage.
Involving children and adolescents with type 1 diabetes in health care: a qualitative study of the use of patient-reported outcomes
Authors: Lassen Rikke Bjerre , Abild Caroline Bruun , Kristensen Kurt , Kristensen Lene Juel , Hørlück Jens Thusgård , Jensen Annesofie Lunde 
Published: March 2023

Abstract
Background
Within pediatric health care services, Patient-reported Outcomes (PROs) regarding the patient’s health status are mainly used for research purposes in a chronic care setting. However, PROs are also applied in clinical settings in the routine care of children and adolescents with chronic health conditions. PROs have the potential to involve patients because they ‘place the patient at the center’ of his or her treatment. The investigation of how PROs are used in the treatment of children and adolescents and how this use can influence the involvement of these patients is still limited. The aim of this study was to investigate how children and adolescents with type 1 diabetes (T1D) experience the use of PROs in their treatment with a focus on the experience of involvement.

Results
Employing Interpretive Description, 20 semi-structured interviews were conducted with children and adolescents with T1D. The analysis revealed four themes related to the use of PROs: Making room for conversation, Applying PROs under the right circumstances, Questionnaire structure and content, and Becoming partners in health care.

Conclusions
The results clarify that, to some extent, PROs fulfill the potential they promise, including patient-centered communication, detection of unrecognized problems, a strengthened patient-clinician (and parent-clinician) partnership, and increased patient self-reflection. However, adjustments and improvements are needed if the potential of PROs is to be fully achieved in the treatment of children and adolescents.
Effect of genotypes and foliar spray of methyl jasmonate and salicylic acid on andrographolide yield in Andrographis paniculata (Burm. f.) Wall. ex Nees. under semi-arid climate
Authors: Kalariya Kuldeepsingh A. , Shahi Deep , Saran Parmeshwar Lal , Meena Ram Prasnna , Gajbhiye Narendra , Sarkar Rohan , Geetha K. A. 
Published: March 2023

Abstract
Background
Andrographis paniculata (Burm. f.) Wall. ex Nees. is an important medicinal plant grown in tropical and sub-tropical regions where semi-arid condition restricts economically viable cultivation. Foliar exogenous application of methyl jasmonate (MeJ) and salicylic acid (SA) was tested for their effectiveness in preventing yield loss in five different morphotypes of A. paniculata subjected to deficit soil moisture stress imposed during 90–140 days after transplanting.

Results
Soil moisture content below 6% reduced chlorophyll and carotenoid content and upregulated antioxidant enzymes activity. The dry herbage yield was adversely affected by deficit soil moisture stress causing a 14% decline. The andrographolide concentration ranged between 1.40% and 1.54%. Though andrographolide concentration increased by 6%, andrographolide yield declined by 8.21% due to soil moisture stress. Moderately high doses of MeJ and SA reduced chlorophyll and carotenoid content and upregulated antioxidant enzymes activity, however, failed to prevent the loss in dry herbage yield or total andrographolide yield in any morphotype.

Conclusions
Foliar application of MeJ and SA do not warrant any protection against stress induced yield loss in field grown A. paniculata. However, morphotype AP 13 (round canopy, open-type branch, long narrow leaf) and AP 35 (columnar canopy, closed-type branch, long broad leaf) for having comparatively high herbage yield remained at a better position for total andrographolide yield under deficit soil moisture stress in the semi-arid climate.
Antimicrobial treatment of patients with a periprosthetic joint infection: basic principles
Authors: Rottier Wouter , Seidelman Jessica , Wouthuyzen-Bakker Marjan 
Published: March 2023

AbstractThe antibiotic treatment of periprosthetic joint infections (PJI) is complicated by the presence of biofilm produced by bacteria on the abiotic surface of the implant. Bacteria within the deeper layers of the biofilm become metabolically less active, resulting in antibiotic tolerance due to several mechanisms. This review describes the basic principles of antibiotic treatment in PJI in relation to the behavior of bacteria within the biofilm. The concept of biofilm-active antibiotics will be explained from an in vitro as well as in vivo perspective. Evidence from clinical studies on biofilm-active antibiotics in PJI will be highlighted, mainly focusing on the role of rifampicin for Gram-positive microorganisms and fluoroquinolones for Gram-negative microorganisms. The optimal treatment duration will be discussed as the timing of switching to oral antibiotic therapy.
Management of a very rare case of polyorchidism: a case report
Authors: Al Tamr Wissam Jamal , Omran Kareem , Prashan Rajebhosale , al Pooja Agraw 
Published: March 2023

Abstract
Background
Polyorchidism is a rare genetic anomaly characterized by the patient having more than two testicles. In the literature, only around two hundred cases have been reported. We present an unusual new case which does not conform to the traditional classifications of polyorchidism or previously reported cases. We discuss our diagnostic techniques as well as management decisions for this case and aim to raise awareness about the management choices available.

Case report
A 3-year-old male presented to the clinic by his parents due to concern of a painless swelling in the left inguinal region. Physical examination revealed features of a left indirect inguinal hernia. Furthermore, scrotal examination revealed a firm, non-compressible painless mass in the left scrotum which was inferior to the left testis. Ultrasonography suggested the mass as an extra testis, and MRI was followed which showed no signs of malignancy. Due to the reassuring nature of these findings, a conservative approach was taken, with the patient referred for regular follow-up.

Conclusion
When facing cases of polyorchidism, physicians should move away from considering surgical excision and biopsy as exclusive first-line management. Instead, we place emphasize and raise awareness about the option of conservative management if imaging shows no abnormalities. Ultimately, the aim of this paper is to raise awareness among the paediatric surgeon community that while excision may be a valid option, it is not the only treatment.
Few-shot image classification algorithm based on attention mechanism and weight fusion
Authors: Meng Xiaoxia , Wang Xiaowei , Yin Shoulin , Li Hang 
Published: March 2023

AbstractAiming at the existing problems of metric-based methods, there are problems such as inadequate feature extraction, inaccurate class feature representation, and single similarity measurement. A new model based on attention mechanism and weight fusion strategy is proposed in this paper. Firstly, the image is passed through the conv4 network with channel attention mechanism and space attention mechanism to obtain the feature map of the image. On this basis, the fusion strategy is used to extract class-level feature representations according to the difference in contributions of different samples to class-level feature representations. Finally, the similarity scores of query set samples are calculated through the network to predict the classification. Experimental results on the miniImageNet dataset and the omniglot dataset demonstrate the effectiveness of the proposed method.
Building Capability and Capacity: The Establishment of an Oncology Unit in the Solomon Islands
Authors: Yip Desmond , Soma Andrew , Pati Nalini , Spencer Wendy , Hua Beth , Jagilly Rooney 
Published: March 2023

PURPOSE To describe the establishment of an oncology unit at the National Referral Hospital (NRH) in the Solomon Islands, a low-income nation in the South Pacific. METHODS A scoping visit was carried out in 2016 to assist in the development of coordinated cancer services and to establish a medical oncology unit at the NRH at the request of the Medical Superintendent. This was followed by an observership visit to Canberra by an NRH doctor training in oncology in 2017. After a request from the Solomon Islands Ministry of Health, the Australian Government Department of Foreign Affairs and Trade (DFAT) arranged an in-country multidisciplinary mission under the Royal Australasian College of Surgeons/Royal Australasian College of Physicians Pacific Islands Program to help in the commissioning of the NRH Medical Oncology Unit in September 2018. Staff training and education sessions were held. The team, with the assistance of an Australian Volunteers International Pharmacist, has helped the NRH staff to develop localized Solomon Islands Oncology Guidelines. Donated equipment and supplies have helped with the initial establishment of the service. A second DFAT Oncology mission visit was made in 2019 followed by two NRH oncology nurses visiting Canberra on observership later that year and support of the Solomon's doctor to pursue postgraduate education in cancer sciences. Ongoing mentorship and support has been maintained. RESULTS The island nation now has a sustainable oncology unit delivering chemotherapy treatments and management of patients with cancer. CONCLUSION A collaborative multidisciplinary team approach by professionals from the high-income country working with colleagues from the low-income nation with coordination of different stakeholders was the key to this successful initiative in improving cancer care.
Cost-Effectiveness of Next-Generation Sequencing Versus Single-Gene Testing for the Molecular Diagnosis of Patients With Metastatic Non–Small-Cell Lung Cancer From the Perspective of Spanish Reference Centers
Authors: Arriola Edurne , Bernabé Reyes , Campelo Rosario García , Biscuola Michele , Enguita Ana Belén , López-Ríos Fernando , Martínez Rafael , Mezquita Laura , Palanca Sarai , Pareja María Jesús , Zugazagoitia Jon , Arrabal Natalia , García J. Francisco , Carcedo David , de Álava Enrique 
Published: March 2023

PURPOSE The aim of this study was to assess the cost-effectiveness of using next-generation sequencing (NGS) versus single-gene testing (SgT) for the detection of genetic molecular subtypes and oncogenic markers in patients with advanced non–small-cell lung cancer (NSCLC) in the setting of Spanish reference centers. METHODS A joint model combining decision tree with partitioned survival models was developed. A two-round consensus panel was performed to describe clinical practice of Spanish reference centers, providing data on testing rate, prevalence of alterations, turnaround times, and treatment pathways. Treatment efficacy data and utility values were obtained from the literature. Only direct costs (euros, 2022), obtained from Spanish databases, were included. A lifetime horizon was considered, so a 3% discount rate for future costs and outcomes was considered. Both deterministic and probabilistic sensitivity analyses were performed to assess uncertainty. RESULTS A target population of 9,734 patients with advanced NSCLC was estimated. If NGS was used instead of SgT, 1,873 more alterations would be detected and 82 more patients could potentially be enrolled in clinical trials. In the long term, using NGS would provide 1,188 additional quality-adjusted life-years (QALYs) in the target population compared with SgT. On the other hand, the incremental cost of NGS versus SgT in the target population was €21,048,580 euros for a lifetime horizon (€1,333,288 for diagnosis phase only). The obtained incremental cost-utility ratios were €25,895 per QALY gained, below the standard cost-effectiveness thresholds. CONCLUSION Using NGS in Spanish reference centers for the molecular diagnosis of patients with metastatic NSCLC would be a cost-effective strategy over SgT.
Influence of simultaneous weak measurements in Heisenberg uncertainty relation
Authors: Wei Tao , Xu Youyang 
Published: March 2023

Abstract
In quantum mechanics the simultaneous measurement of non-commuter variables has attracted widespread attention. Here we propose a scheme through simultaneously weak measurement to achieve the approximated weak values of two non-commuting variables. It can be observed that the measurement error is better than the Heisenberg uncertainty relation. Furthermore, the effects of free Hamiltonian and higher-order expansion of the time evolution operator are considered.
Characteristics of Pain During MRI-Guided Focused Ultrasound Thalamotomy
Authors: He Xin , Oshino Satoru , Hosomi Koichi , Kanemoto Manabu , Tani Naoki , Kishima Haruhiko 
Published: March 2023

BACKGROUND:
Magnetic resonance imaging–guided focused ultrasound (MRgFUS) has become popular as an incisionless mode of neurosurgical treatment. However, head pain during sonication is common and its pathophysiology remains poorly understood.

OBJECTIVE:
To explore the characteristics of head pain occurring during MRgFUS thalamotomy.

METHODS:
Our study comprised 59 patients who answered questions about the pain they experienced during unilateral MRgFUS thalamotomy. The location and features of pain were investigated using a questionnaire including the numerical rating scale (NRS) to estimate maximum pain intensity and the Japanese version of the Short Form of McGill Pain Questionnaire 2 to evaluate the quantitative and qualitative dimensions of pain. Several clinical factors were investigated for possible correlation with pain intensity.

RESULTS:
Forty-eight patients (81%) reported sonication-related head pain, and the degree of pain was severe (NRS score ≥ 7) in 39 patients (66%). The distribution of sonication-related pain was “localized” in 29 (49%) and “diffuse” in 16 (27%); the most frequent location was the “occipital” region. The pain features most frequently reported were those in the “affective” subscale of the Short Form of McGill Pain Questionnaire 2. Patients with diffuse pain had a higher NRS score and lower skull density ratio than did patients with localized pain. The NRS score negatively correlated with tremor improvement at 6 months post-treatment.

CONCLUSION:
Most patients in our cohort experienced pain during MRgFUS. The distribution and intensity of pain varied according to the skull density ratio, indicating that the pain might have had different origins. Our results may contribute to the improvement of pain management during MRgFUS.