bluuebunny/crossref_metadata_2025_split huggingface dataset:
De l’écorce à l’enveloppe : tissage et mé-tissage des contenants culturels à l’école
Authors: Nguyen-Viet Thuy-Trang Céline 
Published: April 2023

Cet article porte sur l’accompagnement des enfants allophones arrivant au sein des écoles primaires après des parcours de migration complexes et parfois traumatogènes. Comment penser un espace contenant pour ces enfants dont les récits rapportés par leur famille décrivent des traversées de territoires, géographiques et psychiques fragilisés et/ou troués ? Comment, en tant que psychologue clinicienne intervenant dans les écoles primaires, pouvons-nous aider les équipes enseignantes à les soutenir dans des modalités d’inclusion efficaces et bienveillantes ? Notre dispositif s’est construit sur l’hypothèse qu’un temps-espace intermédiaire en groupe est nécessaire dans la phase d’appropriation d’un nouvel environnement scolaire par les enfants allophones. Les modalités de fonctionnement du dispositif ont été pensées par l’enseignante et le Réseau d’aide spécialisée pour les élèves en difficulté ( rased ou Réseau). Le « Réseau » est composé d’enseignants spécialisés à dominante relationnelle et à dominante pédagogique, ainsi qu’une psychologue, poste que j’avais occupé dans cet établissement.
Borrelia burgdorferi Engages Mammalian Type I IFN Responses via the cGAS–STING Pathway
Authors: Farris Lauren C , Torres-Odio Sylvia , Adams L Garry , West A Phillip , Hyde Jenny A 
Published: April 2023

Abstract
Borrelia burgdorferi, the etiologic agent of Lyme disease, is a spirochete that modulates numerous host pathways to cause a chronic, multisystem inflammatory disease in humans. B. burgdorferi infection can lead to Lyme carditis, neurologic complications, and arthritis because of the ability of specific borrelial strains to disseminate, invade, and drive inflammation. B. burgdorferi elicits type I IFN (IFN-I) responses in mammalian cells and tissues that are associated with the development of severe arthritis or other Lyme-related complications. However, the innate immune sensors and signaling pathways controlling IFN-I induction remain unclear. In this study, we examined whether intracellular nucleic acid sensing is required for the induction of IFN-I to B. burgdorferi. Using fluorescence microscopy, we show that B. burgdorferi associates with mouse and human cells in culture, and we document that internalized spirochetes colocalize with the pattern recognition receptor cyclic GMP-AMP synthase (cGAS). Moreover, we report that IFN-I responses in mouse macrophages and murine embryonic fibroblasts are significantly attenuated in the absence of cGAS or its adaptor stimulator of IFN genes (STING), which function to sense and respond to intracellular DNA. Longitudinal in vivo tracking of bioluminescent B. burgdorferi revealed similar dissemination kinetics and borrelial load in C57BL/6J wild-type, cGAS-deficient, or STING-deficient mice. However, infection-associated tibiotarsal joint pathology and inflammation were modestly reduced in cGAS-deficient compared with wild-type mice. Collectively, these results indicate that the cGAS–STING pathway is a critical mediator of mammalian IFN-I signaling and innate immune responses to B. burgdorferi.
Here, There, and Everywhere: Myeloid-Derived Suppressor Cells in Immunology
Authors: Ostrand-Rosenberg Suzanne , Lamb Tracey J , Pawelec Graham 
Published: April 2023

Abstract
Myeloid-derived suppressor cells (MDSCs) were initially identified in humans and mice with cancer where they profoundly suppress T cell– and NK cell–mediated antitumor immunity. Inflammation is a central feature of many pathologies and normal physiological conditions and is the dominant driving force for the accumulation and function of MDSCs. Therefore, MDSCs are present in conditions where inflammation is present. Although MDSCs are detrimental in cancer and conditions where cellular immunity is desirable, they are beneficial in settings where cellular immunity is hyperactive. Because MDSCs can be generated ex vivo, they are being exploited as therapeutic agents to reduce damaging cellular immunity. In this review, we discuss the detrimental and beneficial roles of MDSCs in disease settings such as bacterial, viral, and parasitic infections, sepsis, obesity, trauma, stress, autoimmunity, transplantation and graft-versus-host disease, and normal physiological settings, including pregnancy and neonates as well as aging. The impact of MDSCs on vaccination is also discussed.
Is cesarean section a clinical marker for psychiatric and sleep disorder in young mothers? A cross-sectional study from rural South India
Authors: Ryali Sumalatha , Kumar Mulinti S. , Ryali V.S.S.R. , Paspulati Sreelatha 
Published: April 2023

ABSTRACT

Background:
Gestation and postnatal period are important stages in a woman’s life. The type of delivery, vaginal delivery (VD) or cesarean Section (CS), is determined by maternal and fetal factors and their mutual fit. The type of delivery has consequences on the health and well-being of the mother and the newborn. Postpartum psychiatric disorders have been found to be both positively and negatively associated with the mode of delivery and demographic and clinical variables of the postpartum mothers. In view of the foregoing, a comprehensive investigation of the demographic and clinical variables and a range of psychiatric disorders among postpartum women delivered both vaginally and by CS in a rural tertiary care hospital in South India was proposed.

Materials and Methods:
All consecutive women delivered vaginally and by CS attending Maternal and Child Clinic within 42 days of delivery were approached. Following informed consent and application of inclusion and exclusion criteria, 121 women delivered vaginally and 124 women delivered by CS were assessed using Mini International Neuropsychiatric Interview (MINI) and Pittsburgh Sleep Quality Index (PSQI). The data obtained were entered into MS Excel 2010 version and further analyzed using STATA v13.

Results:
Both groups were matched on most demographic and clinical variables except age and whether pregnancy was planned or not. Postpartum depression was the most frequent diagnosis in both groups, with significantly more cases following CS compared to VD. Other psychiatric disorders were also found to be more following CS. The quality of sleep (QOS) was significantly poor following CS. QOS was significantly poor in the presence of a coexisting psychiatric disorder.

Conclusion:
This study has limitations in terms of being cross-sectional and disability being defined by cutoff scores on MINI and PSQI.
Selecting a thesis topic: A postgraduate’s dilemma
Authors: Saini Rajiv K. , Issac Mohan , Kumar K. J. D. , Chaudhury Suprakash , Sharma Rachit , Dangi Ankit , Chail Amit 
Published: April 2023

ABSTRACT
It is said that well begun is half done. Choosing a thesis topic and submitting a research protocol is an essential step in the life cycle of a postgraduate resident. National Medical Commission of India mandates that all postgraduate trainees must submit at least one original research work (dissertation), one oral paper, one poster, and one publication to be eligible for final year examination. It is the duty of the faculty to ensure that trainees take active interest and submit their theses on time. However, their journey is often marred by multiple challenges and hurdles. The literature was searched from year 2000 onwards till 2011 using Pubmed, ResearchGate, MEDLINE, and the Education Resources Information Centre databases with terms related to residency training, selecting thesis topic, challenges or hurdles, and conversion of thesis into journal article. Existing literature on the subject matter is sparse. Current article advocates promotion of ethical and original research during postgraduation and proposes a checklist for residents before submission of their proposals.
Five-year outcome of aflibercept intravitreal injection in naïve patients with neovascular age-related macular degeneration using a modified treat-and-extend regimen: Results from a prospective observational study
Authors: Charles Jarret , Chau TRAN Thi Ha 
Published: April 2023

Abstract

PURPOSE:
The purpose is to study the 5-year results of aflibercept monotherapy using an individualized regimen in naïve patients with neovascular AMD (nAMD).

MATERIALS AND METHODS:
This is a prospective observational study including naïve nAMD patients who underwent aflibercept injections with at least 5 years of follow-up. All of them received 3 monthly injections at the loading phase, followed by an observation period, then treated with an individualized treat-and-extend regimen. Visual acuity (VA) measurement and optical coherence tomography were performed at each visit.

RESULTS:
Forty-eight eyes were included. Of these, 30 were followed up for 5 years. The mean follow-up was 61.7 ± 2.3 months. The mean age was 81 ± 8 years. The visual gain was 7.3 ± 12.7 letters at 1 year, 6.5 ± 12.5 letters at 2 years, 5.2 ± 17 letters at 3 years, 6.2 ± 18.6 letters at 4 years, and 5.6 ± 20 letters at 5 years. At the last observation, 53% of eyes had VA > 70 letters. A complete fluid resolution was obtained in 53% of the eyes. At the 5-year endpoint, the total number of injections was 21.6 ± 13.4. Macular atrophy was observed in 18 eyes (60%) and subretinal fibrosis in 14 eyes (46%).

CONCLUSION:
Patients with exudative AMD can maintain their visual function at 5 years with aflibercept using an individualized treatment. The loss of visual gain beyond 2 years could be related to the natural progression of the disease than the direct effect of anti-vascular endothelial growth injections.
Mentorship Programs in Residency: A Scoping Review
Authors: Joe Moss Bruton , Cusano Anthony , Leckie Jamie , Czuczman Natalie , Exner Kyle , Yong Heather , Ruzycki Shannon , Lithgow Kirstie 
Published: April 2023

ABSTRACT

Background
Mentorship during residency training is correlated with improved outcomes. Many residency programs have implemented formal mentorship programs; however, reported data for these programs have not been previously synthesized. Thus, existing programs may fall short on delivering effective mentorship.

Objective
To synthesize current literature on formal mentorship programs in residency training in Canada and the United States, including program structure, outcomes, and evaluation.

Methods
In December 2019, the authors performed a scoping review of the literature in Ovid MEDLINE and Embase. The search strategy included keywords relevant to mentorship and residency training. Eligibility criteria included any study describing a formal mentorship program for resident physicians within Canada or the United States. Data from each study were extracted in parallel by 2 team members and reconciled.

Results
A total of 6567 articles were identified through the database search, and 55 studies met inclusion criteria and underwent data extraction and analysis. Though reported program characteristics were heterogenous, programs most commonly assigned a staff physician mentor to a resident mentee with meetings occurring every 3 to 6 months. The most common evaluation strategy was a satisfaction survey at a single time point. Few studies performed qualitative evaluations or used evaluation tools appropriate to the stated objectives. Analysis of data from qualitative studies allowed us to identify key barriers and facilitators for successful mentorship programs.

Conclusions
While most programs did not utilize rigorous evaluation strategies, data from qualitative studies provided insights into barriers and facilitators of successful mentorship programs, which can inform program design and improvement.
Virtual Brunches to Enhance Recruitment of Residents and Fellows Who Self-Identify as Underrepresented in Medicine
Authors: Sonoda Kento , Hamilton Melinda , Bump Gregory M. , Rosser Brittany , Doughty Brandon , Tripp Rickquel 
Published: April 2023

ABSTRACT

Background
Our institution, along with many others, struggles to recruit residents and fellows who identify as underrepresented in medicine (UIM). There have been various program-level interventions implemented across the nation; however, little is known about graduate medical education (GME)-wide recruiting events for UIM trainees.

Objective
We describe the development, implementation, and evaluation of a GME-wide recruitment program, Virtual UIM Recruitment Diversity Brunches (VURDBs), to meet this need.

Methods
A virtual, 2-hour event was held 6 times on Sunday afternoons between September 2021 and January 2022. We surveyed participants on a rating of the VURDBs from excellent (4) to fair (1) and their likelihood of recommending the event to their colleagues from extremely (4) to not at all (1). We used institutional data to compare pre- and post-implementation groups using a 2-sample test of proportions.

Results
Across 6 sessions, 280 UIM applicants participated. The response rate of our survey was 48.9% (137 of 280). Fifty-eight percent (79 of 137) rated the event as excellent, and 94.2% (129 of 137) were extremely or very likely to recommend the event. The percentage of new resident and fellow hires who identify as UIM significantly increased from 10.9% (67 of 612) in academic year 2021-2022 to 15.4% (104 of 675) in academic year 2022-2023. The percentage of brunch attendees matriculating into our programs in academic year 2022-2023 was 7.9% (22 of 280).

Conclusions
VURDBs are a feasible intervention associated with increased rates of trainees identifying as UIM matriculating in our GME programs.
ENTRUST: A Serious Game-Based Virtual Patient Platform to Assess Entrustable Professional Activities in Graduate Medical Education
Authors: Lin Dana T. , Melcer Edward F. , Keehl Oleksandra , Eddington Hyrum , Trickey Amber W. , Tsai Jason , Camacho Fatyma , Merrell Sylvia Bereknyei , Korndorffer James , Liebert Cara A. 
Published: April 2023

ABSTRACT

Background
As entrustable professional activities (EPAs) are implemented in graduate medical education, there is a great need for tools to efficiently and objectively evaluate clinical competence. Readiness for entrustment in surgery requires not only assessment of technical ability, but also the critical skill of clinical decision-making.

Objective
We report the development of ENTRUST, a serious game-based, virtual patient case creation and simulation platform to assess trainees' decision-making competence. A case scenario and corresponding scoring algorithm for the Inguinal Hernia EPA was iteratively developed and aligned with the description and essential functions outlined by the American Board of Surgery. In this study we report preliminary feasibility data and validity evidence.

Methods
In January 2021, the case scenario was deployed and piloted on ENTRUST with 19 participants of varying surgical expertise levels to demonstrate proof of concept and initial validity evidence. Total score, preoperative sub-score, and intraoperative sub-score were analyzed by training level and years of medical experience using Spearman rank correlations. Participants completed a Likert scale user acceptance survey (1=strongly agree to 7=strongly disagree).

Results
Median total score and intraoperative mode sub-score were higher with each progressive level of training (rho=0.79, P&lt;.001 and rho=0.69, P=.001, respectively). There were significant correlations between performance and years of medical experience for total score (rho=0.82, P&lt;.001) and intraoperative sub-scores (rho=0.70, P&lt;.001). Participants reported high levels of platform engagement (mean 2.06) and ease of use (mean 1.88).

Conclusions
Our study demonstrates feasibility and early validity evidence for ENTRUST as an assessment platform for clinical decision-making.
Üniversite Öğrencilerinin Menstrüel Sağlık Sorunları İçin Başvurdukları Geleneksel ve Tamamlayıcı Tıp Uygulamalarının Belirlenmesi
Authors: UYUŞLU Nilay , BAŞOĞLU Melih , UTKUALP Nevin 
Published: April 2023

Amaç: Bu araştırma menstrüel sağlık sorunları yaşayan üniversite öğrencilerinin geleneksel ve tamamlayıcı tıp (GETAT) yöntemlerini kullanma durumlarının ve kullanılan geleneksel ve tamamlayıcı tıp yöntemlerinin belirlenmesi amacıyla yapılmıştır.
Gereç ve Yöntem: Tanımlayıcı-kesitsel olan araştırma 1 Ocak - 30 Haziran 2020 tarihlerinde bir üniversite öğrencileri ile yapılmıştır. Araştırmanın örneklemini 436 öğrenci oluşturmaktadır. Verilerin değerlendirilmesinde, yüzde ve ki-kare testi kullanılmıştır.
Bulgular: Katılımcıların %65.4’ü menstrüel sağlık sorunları için geleneksel ve tamamlayıcı tıp yöntemlerine başvurmaktadır. Geleneksel ve tamamlayıcı tıp yöntemlerinden aktivite/egzersiz alanında katılımcıların %70.4’ü abdomene sıcak uygulama yapmakta; kültürel/dini uygulamalar alanında katılımcıların %41.3’ü menstrüel sağlık sorunlarıyla baş etmek için dua etmekte; bitkisel tedavi alanında katılımcıların %38.1’i papatya çayı içmektedir. Katılımcıların %49.3’ü kullanmakta olduğu geleneksel ve tamamlayıcı tıp yöntemini ailesinden öğrenmiştir. En sık başvurulan geleneksel ve tamamlayıcı tıp yönteminin abdomene sıcak su uygulama olduğu görülmüştür. Katılımcıların çoğunluğu geleneksel ve tamamlayıcı tıp yöntemlerini fayda gördükten sonra bırakmıştır.
Sonuç: Araştırmada katılımcıların menstrüel sağlık sorunları yaşadığı ve bu sorunlara yönelik geleneksel ve tamamlayıcı tıp yöntemlerine başvurabildikleri saptanmıştır.
PERSEPSI MASYARAKAT TENTANG VAKSINASI COVID-19 DI KELURAHAN PULO BRAYAN MEDAN
Authors: Tamba Darwin , Tampubolon Pretty Pretty L. , Saragih Herna Anzly 
Published: April 2023

Coronavirus Disease 2019 (Covid-19) merupakan penyakit menular yang menyerang saluran pernafasan dan menyebar ke berbagai benua dan negara yang disebut sebagai pandemi.Virus Covid-19 pertama masuk ke indonesia pada bulan Maret 2020 yang menjadi masalah terhadap masyarakat Indonesia.WHO menyatakan agar negara didunia meningkatkan kewaspadaan dalam mencegah maupun menangani Covid-19. Penyakit Covid-19 tidak hanya dapat merugikan dari segi kesehatan masyarakat tetapi juga berdampak bagi perekonomian masyarakat Indonesia. Untuk mencegah penularan Covid-19 ada berbagai upaya yang dilakukan salah satunya adalah vaksinasi Covid-19. Pemberian vaksinasi Covid-19 kepada masyarakat berjalan lambat karena tanggapan masyarakat mengenai vaksinasi bahwa vaksinasi itu dapat menimbulkan penyakit atau bahkan kematian padahal vaksinasi tersebut dapat meningkatkan kekebalan tubuh masyarakat. Penelitian ini bertujuan untuk mengetahui persepsi masyarakat tentang vaksinasi Covid-19 di Kelurahan Pulo Brayan Medan. Jenis penelitian yang digunakan dalam penelitian ini adalah deskriptif. Teknik pengambilan sampel adalah Purposive Sample. Populasi dalam penelitian ini adalah seluruh masyarakat yang belum divaksinasi dengan jumlah penduduk di Kelurahan Pulo Brayan Kecamatan Medan Barat dari Lingkungan 1-4 sebanyak 3.425 jiwa. Sampel dalam penelitian ini adalah sebagian masyarakat yang belum divaksinasi dari lingkungan 1-4 sebanyak 97 orang. instrumen penelitian ini menggunakan kuesioner persepsi masyarakat tentang vaksinasi Covid-19 dalam bentuk pernyataan dengan menggunakan Skala Likert. Hasil penelitian menunjukan bahwa persepsi masyarakat tentang vaksinasi Covid-19 lebih banyak yang memiliki persepsi positif sebanyak 59 orang (60,8%) dan Negatif sebanyak 38 orang (39,2%). Diharapkan kepada masyarakat agar dapat meningkatkan pengetahuan tentang vaksinasi Covi-19 melalui sosial media.
ANALISIS PUTUSAN HAKIM PERKARA NOMOR 178/PDT.G/2022/PN. PTK. TERHADAP WANPRESTASI DALAM PERJANJIAN KERJASAMA PENERBITAN SERTIFIKAT TANAH
Authors: Rahman Abdul 
Published: April 2023

Wanprestasi dapat terjadi dikarenaka dari salah satu pihak ada yang tidak melakukan apa yang telah menjadi kesepakatan dalam perjanjian. Dalam putusan perkara nomor 178/Pdt.G/PN Ptk merupakan jenis perkara wanprestasi yang terjadi dalam perjanjian kerjasama dalam penerbitan sertifikat. Majelis hakim dalan pertimbangannya mengabulkan gugatan wanprestasi penggugat sebagian dan mengabulkan gugatan penggugat sebagian. Tujuan dari penelitian ini untuk melihat apa yang menjadi dasar pertimbangan hakim dalam memutus perkara 178/Pdt.G/PN Ptk. Metode yang digunakan dalam penelitian ini adalah metode pendekatan normatif. Hasil penelitian dilihat dari aspek keadilan, kemanfaatan dan kepastian hukum dalam pertimbangan hukum putusan tersebut telah memenuhi unsur perkara wanprestasi karena dalam persidangan terungkap dari bukti-bukti (bukti P-1 hingga P-3) yang diajukan oleh penggugat dan tergugat terbukti tidak melakukan apa yang telah disepakati bersama. Dengan demikian, hakim menghukum tergugat harus mengembalikan uang yang telah diterimanya dari penggugat sejumlah Rp 4.268.000.000. (empat miliyard dua ratus enam puluh delapan) dan menghukum tergugat secara tunai sebagai hasil keuntungan sebesar 6.578.000.000 (enam miliyard lima ratus tujuh puluh delapan juta rupiah) kepada penguggat. Tetapi, dalam putusan pengadilan tersebut mengabulkan sebagian dan tidak mengabulkan sebagian yakni tidak mengabulkan terkait tuntutan uang bayar paksa (dwangsom) dengan pertimbangan bahwa dwangsom dianggap berlebihan dan memberatkan tergugat.
PENGARUH KOMUNIKASI KEPALA SEKOLAH TERHADAP MOTIVASI KINERJA GURU SMA GKPI PADANG BULAN
Authors: Siregar Maju , Panjaitan Doli Tua Mulia Raja 
Published: April 2023

Guru merupakan pendidik dalam proses pembelajaran, yang memiliki tugas utama adalah mendidik dan mengajar. Guru dituntut mencari tahu terus-menerus bagaimana seharusnya peserta didik itu belajar. Potensi yang dimiliki Guru perlu ditingkatkan melalui komunikasi kepala sekolah. Kepala sekolah merupakan sumber pesan (informasi) di sekolah yang dibutuhkan oleh pendidik dan disampaikan, supaya terlaksana dalam pengembangan guru dan siswa (Fatimah, dkk, 2015). Upaya meningkatkan kinerja guru tidak selalu berkembang dengan lancar, karena banyak faktor yang mempengaruhi baik itu muncul dari diri sendiri maupun dari luar pribadi guru. Mengarah kepada masalah yang dihadapi sekolah SMA GKPI Padang Bulan yang menguraikan beberapa guru belum tepat waktu menyerahkan laporan hasil kinerjanya seperti RPP, Silabus, Prota dan Prosen, daftar kegiatan harian kinerja guru, selain itu guru masih ada yang terlambat datang ke sekolah, yang akhirya memunculkan kurang profesionalnya kinerja guru tersebut. Selain itu, kondisi guru belum sesuai dengan harapan seperti masih terdapat guru bekerja sambilan, ada diluar profesi, ada menekuni kegiatan rutinitas ((Fatimah, dkk, 2015) seperti berladang. Realitanya banyak guru beranggapan bahwa profesi guru itu adalah pekerjaa biasa, sehingga nilai-nilai pendidikan kurang ditanamkan pada peserta didik. Oleh karena itu, sebagai tugas tambahan kepala sekolah dalam mempimpin suatu lembaga, dimana agar pengembangan profesional kinerja guru dapat berjalan lancar diperlukan komunikasi yang efektif oleh kepala sekolah. Uraian tersebut merumuskan masalah “Apakah komunikasi kepala sekolah mampu mempengaruhi motivasi kinerja guru SMA GKPI Padang Bulan Medan?”, sehingga terjawablah, hasil penelitian diperoleh nilai thitung 1,307 dan nilai probabilitas sig. 0,197 bermakna adanya pengaruh komunikasi kepala sekolah terhadap motivasi kineja guru.