bluuebunny/crossref_metadata_2025_split huggingface dataset:
Automated Machine Learning Analysis of Patients With Chronic Skin Disease Using a Medical Smartphone App: Retrospective Study
Authors: Bibi Igor , Schaffert Daniel , Blauth Mara , Lull Christian , von Ahnen Jan Alwin , Gross Georg , Weigandt Wanja Alexander , Knitza Johannes , Kuhn Sebastian , Benecke Johannes , Leipe Jan , Schmieder Astrid , Olsavszky Victor 
Published: September 2023

Background
Rapid digitalization in health care has led to the adoption of digital technologies; however, limited trust in internet-based health decisions and the need for technical personnel hinder the use of smartphones and machine learning applications. To address this, automated machine learning (AutoML) is a promising tool that can empower health care professionals to enhance the effectiveness of mobile health apps.

Objective
We used AutoML to analyze data from clinical studies involving patients with chronic hand and/or foot eczema or psoriasis vulgaris who used a smartphone monitoring app. The analysis focused on itching, pain, Dermatology Life Quality Index (DLQI) development, and app use.

Methods
After extensive data set preparation, which consisted of combining 3 primary data sets by extracting common features and by computing new features, a new pseudonymized secondary data set with a total of 368 patients was created. Next, multiple machine learning classification models were built during AutoML processing, with the most accurate models ultimately selected for further data set analysis.

Results
Itching development for 6 months was accurately modeled using the light gradient boosted trees classifier model (log loss: 0.9302 for validation, 1.0193 for cross-validation, and 0.9167 for holdout). Pain development for 6 months was assessed using the random forest classifier model (log loss: 1.1799 for validation, 1.1561 for cross-validation, and 1.0976 for holdout). Then, the random forest classifier model (log loss: 1.3670 for validation, 1.4354 for cross-validation, and 1.3974 for holdout) was used again to estimate the DLQI development for 6 months. Finally, app use was analyzed using an elastic net blender model (area under the curve: 0.6567 for validation, 0.6207 for cross-validation, and 0.7232 for holdout). Influential feature correlations were identified, including BMI, age, disease activity, DLQI, and Hospital Anxiety and Depression Scale-Anxiety scores at follow-up. App use increased with BMI >35, was less common in patients aged >47 years and those aged 23 to 31 years, and was more common in those with higher disease activity. A Hospital Anxiety and Depression Scale-Anxiety score >8 had a slightly positive effect on app use.

Conclusions
This study provides valuable insights into the relationship between data characteristics and targeted outcomes in patients with chronic eczema or psoriasis, highlighting the potential of smartphone and AutoML techniques in improving chronic disease management and patient care.
Manfaat Saffron dalam Meringankan Sindrom Pramenstruasi
Authors: Rahayu Nur Setiawati , Safitri Debby Endayani 
Published: September 2023

Background: Menstrual disorders are experienced by most women of reproductive age, this problem if not handled seriously will have an adverse impact. Most women choose to treat menstrual disorders with medical treatment without knowing the side effects of using these drugs.Objective: This study aims to find solutions or alternative in dealing with Premenstrual syndrom other than by medical treatment.Methods: This study uses a systematic review method, where this study examines and integrates findings from published studies to draw conclusions.Results and Discussion: The results of this study indicate that saffron is effective in helping to reduce the severity and reduce the duration of menstrual disorders. Such as anxiety, depression, pain and other disorders.Conclusion: Consumption 30mg of saffron per-day can be useful reducing symptoms of menstrual disorder like depression, pain and hormonal balance. Keywords: Menstrual Disorder, Saffron, Systematic Review
Gambaran Sindroma Pasca menopause Pada Wanita Lansia di Panti Werdha Wisma Mulia, Grogol, Jakarta
Authors: Pramana Cipta , Vincentia Angeline , Dewi Andriana Kumala 
Published: September 2023

ABSTRACTBackground: The number of elderly women will continue to increase along with the high life expectancy. The decline in estrogen and progesterone after menopause causes direct effects in the form of physical and psychological disorders.Objectives: This study aims to describe the symptoms of postmenopausal syndrome in the elderly.Method: Non-probability descriptive sampling method has been carried out in the elderly group of women (N=38). Interviews based on the Guide to Greene Climacteric Scale questionnaire were conducted to collect data.Results and Discussion: Overall, postmenopausal syndrome was experienced by 79.47% of respondents. A total of 26.32% of respondents were very disturbed by anxiety symptoms. 34.21% and 39.47% of respondents were slightly disturbed by depressive and somatic symptoms. Only 5.26% of respondents were very disturbed by the symptoms of sexual dysfunction. Subjects with low education have a risk of 7.8 times experiencing symptoms of postmenopausal syndrome compared to subjects with higher education. Subjects who were nullipara had 2.6 times the risk of experiencing symptoms of postmenopausal syndrome when compared to primi/multipara.Conclusion: More than half of the respondents experienced postmenopausal syndrome, either in the form of symptoms of anxiety, depression, somatic, vasomotor, or sexual dysfunction. Subjects with low education have a higher risk of experiencing postmenopausal syndrome than those with low education.Keywords. Menopaus; elderl; postmenopausal syndrome.
Ketepatan Rumus Risanto untuk Memprediksi Berat Lahir Janin pada Ibu dengan Berat Badan Berlebih
Authors: Zahra Nadia Mutiara , Prawitasari Shinta , Aprizano Vicky Admiral , Rahman Muhammad Nurhadi , Siswosudarmo Risanto 
Published: September 2023

Background: Estimated Fetal Weight (EFW) needs to be as accurate as possible to reflect the actual condition of the fetus for labor-management planning. Risanto’s formula is one of the easy to use formula to estimate fetal weight using fundal height (FH). But, oftentimes, the measurement of fundal height in overweight pregnant mothers is hard to be done precisely due to the thickness of the abdominal subcutaneous fat layer. Therefore, there is a possibility of a decrease in EFW’s accuracy in overweight mothers by using FH measurement.Objective: To determine the accuracy of Risanto’s formula in estimating fetal weight in overweight mothers.Method: It was a cross-sectional study nested within research by Aprizano in 2018. Mothers at term pregnancies with body mass index (BMI) >25 kg/m2 from Sardjito and affiliated hospitals were included in the study. The difference between the mean Risanto’s estimated fetal weight (R_EFW) and the mean actual birth weight (ABW) was analyzed using a paired t-test. Later on, the accuracy of R_EFW was analyzed based on the mean absolute percentage error and the number of cases within <5%, <10%, <15%, and <20% absolute percentage error. EFW can be defined as accurate if the mean absolute percentage error is <10% and/or the number of EFW within + 10% from the ABW is >75%.Results and Discussion: From the 205 research subjects, the mean R_EFW was 3050,49 ± 421,96 gram (ranged from 1995 to 4745 gram), while the mean ABW was 3129,29 ± 406,67 gram (ranged from 1800-4880 gram). Risanto’s formula tends to give a smaller estimation compared to the ABW with the mean difference (∆mean) between the two was 78,8 gram (95% CI: 50,031-107,569 and P=0,000). The mean difference was statistically significant. But, if we convert the ∆mean into a percentage, the mean difference was 2,52%. Other than that, the mean absolute percentage error was 5,8 ± 4,11 %. The number of case within the absolute percentage error of <5%, <10%, <15%, and <20% was 47,3%, 85,9%, 96,6%, and 100% from the overall data in consecutive order.Conclusion: Risanto’s formula was accurate in estimating fetal birth weight in overweight mothers based on the two indicators, in which the mean absolute percentage error was <10% and the number of cases within the + 10% from the ABW was >75%. Keywords: Risanto’s formula; estimated fetal weight; overweight mothers; fetal birth weight
Dampak dan Strategi Layanan Kesehatan Ibu Hamil Selama Pandemi COVID-19
Authors: Elfiyani Nur Khotimah , Pratomo Hadi , Martha Evi , Saraswati Prima Sesari 
Published: September 2023

Background: COVID-19 pandemic has both directly and indirectly affected the provision of the maternal health services. Stress caused by the pandemic also affecting the maternal health service.Objective: This research aimed to assess both the impact on the maternal health services and strategy performed to respond to the COVID-19 pandemic by the District Health Office (DHO) of South Tangerang.Method: The main method of this research is quantitative, then the quantitative findings are described qualitatively. The research team employed an in-depth interview via Zoom application (video teleconference) with 3 informants from the DHO. Meanwhile, the quantitative data were derived from dashboard of maternal health data K1, K4 and PF. Qualitative data are analyzed using theme analysis which is adapted to the findings from those quantitative data.Results and Discussion: The impact of the maternal health service showed a significant decrease against maternal health service in April in which the loss percentage of coverage K1 = 32.93%; coverage K4= 26.43%; Childbirth by health professionals in health facility = 19.4%.Conclusion: The decreasing of maternal health services potentially increase complication to pregnant women and mother and child’s mortality rate. The DHO is suggested to continue improving strategies and efforts to maintain the access of maternal health services during the COVID-19 pandemic.
Analisis Faktor-Faktor Yang Berhubungan Dengan Berhenti Pakai (Drop Out) Kontrasepsi Di Kalimantan Barat (Analisis Data SDKI Tahun 2017)
Authors: Marsita Elma , Kurniatin Lydia Febri , Nur Septi 
Published: September 2023

Latar Belakang: Berhenti pakai (drop out) kontrasepsi merupakan kejadian berhentinya PUS menjadi akseptor KB. Angka kejadian drop out KB di Indonesia mengalami peningkatan, dari 11,46% pada tahun 2008 menjadi 15,09% pada tahun 2012. Hasil SDKI 2017 di Kalimantan Barat menunjukkan 34% wanita usia 15-49 tahun yang sudah menikah dan mulai memakai alat/cara KB dalam 5 tahun sebelum survey, berhenti memakai alat/cara KB dalam waktu 12 bulan setelah mulai memakai. Peningkatan angka drop out KB akan sejalan dengan angka peningkatan jumlah penduduk. Hal ini akan berdampak pada tingkat kesejahteraan, kualitas pendidikan, pembangunan, dan kesehatan sehingga akan menurunkan kualitas penduduk setempat.Tujuan: Menganalisis faktor-faktor yang mempengaruhi kejadian berhenti pakai (drop out) kontrasepsi di Kalimantan Barat berdasarkan hasil analisis data SDKI 2017.Metode: Penelitian ini dirancang menggunakan desain kuantitatif. Responden adalah wanita usia subur dengan status kawin berusia 15-49 tahun yang pernah menggunakan kontrasepsi atau masih menggunakan kontrasepsi saat pengambilan data SDKI tahun 2017 di provinsi Kalimantan Barat. Besar sampel yaitu 490 orang berdasarkan kriteria inklusi dan eksklusi. Data dianalisis secara univariat, bivariat (chi square), dan multivariat (regresi logistik).Hasil dan Pembahasan: Terdapat hubungan yang signifikan antara jenis metode kontrasepsi (OR=2.2|CI95%;1,412-3,565), usia (OR=1.7|CI95%;1,180-2,562), status pekerjaan (OR = 1.5|CI95%;1,024-2,218), paritas (OR = 1.6|CI95%; 1,124-2,427), tempat tinggal (OR = 1.7|CI95%; 1,153-2,623), dukungan pasangan (OR = 14|CI95%; 5,708-34,42), efek samping (OR = 2.3|CI95%; 1,354-3,990), masalah kesehatan (OR = 3.2|CI95%;1,640-6,255), kebersamaan dengan suami (OR = 3.2|CI95%; 1,449-7,223), frekuensi melakukan hubungan seksual (OR = 3.5| CI95%; 2,179-5,618), serta penkes KB dari petugas kesehatan (OR = 2.4|CI95%; 1,448-4,083) terhadap perilaku drop out kontrasepsi. Hasil analisis multivariat menunjukkan bahwa apabila variabel secara bersama-sama dalam kategori baik, maka probabilitas untuk tidak melakukan drop out KB adalah sebesar 94%, sedangkan 6% dipengaruhi oleh variabel lain. Sedangkan tidak ada hubungan antara tingkat pendidikan (OR=0.8|CI95%;0,354-1,708), keterjangkauan jarak pelayanan kesehatan (OR=1.5|CI95%;0,889-2,364), pengetahuan metode KB (OR = 0.9|CI95%;0,519-1,414) dan kunjungan petugas KB ke rumah (OR = 2|CI95%; 0,728-5,319). Kata kunci : Berhenti Pakai; Drop out; Kontrasepsi; SDKI 2017; Kalimantan Barat
Hubungan antara Ekspresi Heat Shock Protein-70 (HSP70) dengan Skor Risk of Ovarian Cancer Relapse (ROVAR) pada Pasien Kanker Ovarium Epitelial yang Dilakukan Operasi dan Dilanjutkan dengan Kemoterapi
Authors: Damaianty Lilik Gretta , Kusumanto Ardhanu , Dewanto Agung 
Published: September 2023

Background: Ovarian cancer is one of the leading causes of death in gynecological malignancies which occupies the third place in the world. One of largest challenge in epithelial ovarian cancer therapy is resistance to chemotherapy. Increased of Heat Shock Protein-70 (HSP70) expression associated with the progressivity of tumor cells growth through the resistance process against chemotherapy, whereas Risk Of Ovarian Cancer Relapse (ROVAR) score is a tool that used to predict the ovarian cancer recurrence risk in patient who underwent surgery followed by chemotherapy.Objective: This study is aimed to evaluate the correlation between HSP70 expression and ROVAR score in patient with epithelial ovarian cancer who underwent first line therapy. Method: This is a retrospective cohort study that involve 42 subjects with epithelial ovarian cancer who had been through surgery (optimal or suboptimal surgery) followed by chemotherapy. Immunohistochemical staining of pre chemotherapy paraffin blocks was performed using HSP70 antibody and recurrence risk was calculated using ROVAR scores after surgery followed by chemotherapy. The external variables evaluated were age, parity, Body Mass Index (BMI), menopause history, and surgical type. Data analysis used Chi Square test, spearman test, and logistic regression analysis.Result and Discussion: Of the total 42 subjects who met the inclusion criteria, most found in advanced stage with the age mean is 54,3 years old. In the ROVAR score measurement, in high risk category is found about 32(76.19%), while in the medium risk and low risk category is 10 (23.81%). On the other hand, strong HSP70 expression was found in 36(85,71%), moderate HSP70 expression in 6(14,39%), and weak HSP70 expression was not found. Based on Spearman's correlative test, there was a positive, very strong, and significant correlation between the expression of HSP70 and risk allocation according to ROVAR score (r=0.717, p=0.000). As well as in multivariate analysis, HSP70 expression had a statistically and clinically significant relationship with ROVAR score (p=0.017; RR 2.710; 95% CI 0.366-5.054) which strong HSP70 expression was 2.71 times more likely to have a high risk of recurrence according to ROVAR score.Conclusion: There is a positive, very strong, and significantly meaning between HSP70 expression and ROVAR score. Increased in HSP70 expression may lead to increased recurrence risk according to ROVAR score. Both could be used to predict recurrence in epithelial ovarian cancer post first line therapy.Keywords: Epithelial ovarian cancer, HSP70, ROVAR score, recurrence.
Rekanalisasi Tuba Fallopi Paska Sterilisasi dan Luaran Kehamilannya: Case Report
Authors: Lutfi Muhammad , Fitriani Annisa 
Published: September 2023

Latar Belakang: Sekitar 1-3% wanita yang telah melakukan sterilisasi berkeinginan untuk memiliki anak kembali di kemudian hari. Sementara beberapa penelitian menunjukkan bahwa kehamilan tidak terencana yang terjadi setelah prosedur sterilisasi dapat meningkatkan risiko kehamilan ektopik. Rekanalisasi tuba fallopi merupakan suatu alternatif dari fertilisasi in vitro (IVF) untuk pasien yang menginginkan kehamilan setelah sterilisasi dan mungkin lebih sesuai untuk dilakukan di negara berkembang karena efektivitas biayanya.Tujuan: Untuk memberikan informasi mengenai prosedur rekanalisasi tuba fallopi yang dilakukan pada wanita yang sebelumnya menjalani sterilisasi serta luaran kehamilannya.Laporan Kasus: Kami melaporkan dua kehamilan pada wanita yang menjalani rekanalisasi tuba fallopi. Pada kedua wanita tersebut dilakukan pendekatan laparotomi mikro dari reanastomosis tuba setelah mengidentifikasi tuba fallopi yang diikat sebelumnya. Pembedahan mikro dilakukan dengan menjahit mesosalping menggunakan bahan polypropylene no. 6.0. Selanjutnya lapisan otot di ujung kedua tuba diidentifikasi dan dijahit secara sistematis pada jam 6, 12, 3, 9 dan diakhiri dengan penjahitan lapisan serosa menggunakan jahitan satu-satu. Uji patensi kedua tuba dilakukan dengan mengalirkan pewarna metilen biru untuk memastikan tidak ada kebocoran dari jahitan reanastomosis. Evaluasi pencitraan HSG satu bulan paska tindakan didapatkan hasil tuba dalam kondisi baik dan kurang lebih satu tahun setelahnya kedua pasien berhasil hamil dan melahirkan dengan kondisi ibu dan bayi baik.Kesimpulan: Keberhasilan rekanalisasi tuba dan kehamilan setelahnya ditentukan sejak dokter melakukan skrining awal pada kandidat operasi, penjelasan yang tepat mengenai teknik prosedur yang dilakukan dan persiapan pre-operasi yang detail dan baik. Banyak studi menyebutkan rekanalisasi tuba fallopi sebagai pilihan yang patut untuk dikerjakan karena memiliki keunggulan pada kelayakan tindakan dan juga efektivitas biayanya. Beberapa faktor penting yang dapat memengaruhi keberhasilan rekanalisasi adalah usia pasien, interval waktu antara sterilisasi dengan tindakan rekanalisasi, tempat ligasi, metode yang digunakan pada ligasi sebelumnya dan sisa panjang tuba setelah operasi. Kata Kunci: rekanalisasi tuba fallopi paska sterilisasi;luaran kehamilan
Infeksi Covid-19 pada Ibu Hamil dan Kejadian Anomali Kongenital: Scoping Review
Authors: Kurniawan Patricia Alika , Hartono Eugenia Maria Alodia , Prawitasari Shinta 
Published: September 2023

Background: Covid-19 (coronavirus disease 2019) is caused by Severe Acute Respiratory Coronavirus (SARS-CoV 2). Pregnant women have higher risk to get infection, including covid-19. Vertical transmission from mother to fetal does not seem to appear in covid-19, but further studies are still needed. Several cases have reported maternal vascular malperfusion and chronic histiocytic intervillositis with trophoblast necrosis in the placenta of mothers infected by covid-19, which can directly affect fetal development in the uterus. To date, little is known about the effect of SARS-CoV 2 infection in pregnancy. However, SARS-CoV 2 infection in the first trimester of pregnancy may have the potential to cause complication such as miscarriage and congenital anomaly.Objective: This study was conducted to describe if there was any influence of covid-19 infection in pregnancy may lead up to the incidence of fetal congenital anomalies.Method: This was a scoping review. Journals that suited inclusion and exclusion criteria were collected and analyzed. The inclusion criteria was journal discussing covid-19 in pregnancy correlated with fetal congenital anomaly. Exclusion criterias were journals not written in English or not full text. The journal was searched on PubMed. Data was presented in the table.Results and Discussion: A scoping review was carried out on 9 journals that matched the inclusion and exclusion criteria. A total of 6 journals did not show any association of congenital anomalies in infants born to mothers infected with covid-19. Three of the six journals did not find any congenital anomalies, while the other three journals consecutively stated that there was no relationship between maternal covid-19 infection and hearing loss, congenital heart disease, and neurodevelopmental delay (hearing loss and retinopathy of prematurity) in infants. One journal concluded that there was a significant increase in fine motor transient abnormalities. One journal concluded that eye abnormalities may be caused by fetomaternal transmission of covid-19 or an indirect effect of maternal covid-19 infection when optic tract development occurred. One journal was unable to conclude whether abnormal brain MRI results in 3 infants had any correlation with mother’s covid-19 infection during pregnancy. There were two journals that found placental insufficiency in subjects infected with covid-19.Conclusion: The correlation between fetal congenital anomaly and maternal covid-19 infection has not been well established. Therefore, further investigation is still needed. Keywords: Congenital Anomaly; Covid-19; Pregnancy
Clinical and Morphological Features of Dysplasia and Early Gastric Cancer in the Patients with Autoimmune Gastritis
Authors: Tertychnyy A. S. , Pachuashvili N. V. , Nagornaya D. P. , Lapina T. L. , Losik E. A. , Ponomarev A. B. , Pavlov P. V. , Kiryukhin A. P. , Fedorenko A. A. , Protsenko D. D. , Ivashkin V. T. 
Published: September 2023

Аim: to analyze a series of cases of dysplasia and early gastric cancer developed in patients with autoimmune gastritis (AIG), and to identify their clinical and morphological features.Materials and methods. The study included six cases of detection of early gastric cancer on the background of AIG. Four out of six patients underwent endoscopic treatment, and in three out of six cases patients underwent endoscopic mucosectomy with dissection in the submucosal layer. One patient underwent endoscopic surgery in 2017, he continues annual dynamic follow-up without signs of tumour recurrence. A female patient with type 1 neuroendocrine tumour and mild dysplasia is awaiting treatment.Results. In five out of six patients with AIG, the localization of lesions prevailed in the stomach body, while all detected tumours were early ones, and according to the immunophenotype — of a gastric type. The presented cases of tumours were not accompanied by hyperplasia of neuroendocrine cells directly in the area of the tumour itself, but only in the surrounding gastric mucosa. Additionally, several cases of early gastrointestinal stromal tumours were found, which were characterized by low proliferative activity and had small sizes.Conclusion. The predominance of pseudopyloric metaplasia in the surrounding mucosa allows us to consider pseudopyloric metaplasia as a potentially significant change in the gastric mucosa of patients with AIG that may precede the development of gastric cancer.