bluuebunny/crossref_metadata_2025_split huggingface dataset:
Outcomes of SARS‐CoV‐2 infection in 126 children and adolescents with central nervous system tumors
Authors: Moreira Daniel C. , Qaddoumi Ibrahim , Chen Yichen , Bhakta Nickhill , Chantada Guillermo L. , Santana Victor M. , Caniza Miguela A. , Devidas Meenakshi , Pritchard‐Jones Kathy , Rodriguez‐Galindo Carlos , Bouffet Eric , Mukkada Sheena ,   the Global Registry of COVID‐19 in Childhood Cancer
Published: May 2023

AbstractBackgroundThe Global Registry of COVID‐19 in Childhood Cancer (GRCCC) seeks to describe the natural history of SARS‐CoV‐2 in children with cancer across the world. Here, we report the disease course and management of coronavirus disease 2019 (COVID‐19) infection in the subset of children and adolescents with central nervous system (CNS) tumors who were included in the GRCCC until February 2021, the first data freeze.ProcedureThe GRCCC is a deidentified web‐based registry of patients less than 19 years of age with cancer or recipients of a hematopoietic stem cell transplant and laboratory‐confirmed SARS‐CoV‐2 infection. Demographic data, cancer diagnosis, cancer‐directed therapy, and clinical characteristics of SARS‐CoV‐2 infection were collected. Outcomes were collected at 30 and 60 days post infection.ResultsThe GRCCC included 1500 cases from 45 countries, including 126 children with CNS tumors (8.4%). Sixty percent of the cases were from middle‐income countries, while no cases were reported from low‐income countries. Low‐grade gliomas, high‐grade gliomas, and CNS embryonal tumors were the most common CNS cancer diagnoses (67%, 84/126). Follow‐up at 30 days was available for 107 (85%) patients. Based on the composite measure of severity, 53.3% (57/107) of reported SARS‐CoV‐2 infections were asymptomatic, 39.3% (42/107) were mild/moderate, and 6.5% (7/107) were severe or critical. One patient died from SARS‐CoV‐2 infection. There was a significant association between infection severity and absolute neutrophil count less than 500 (p = .04). Of 107 patients with follow‐up available, 40 patients (37.4%) were not receiving cancer‐directed therapy. Thirty‐four patients (50.7%) had a modification to their treatment due to withholding of chemotherapy or delays in radiotherapy or surgery.ConclusionIn this cohort of patients with CNS tumors and COVID‐19, the frequency of severe infection appears to be low, although severe disease and death do occur. We found that greater severity was seen in patients with severe neutropenia, although treatment modifications were not associated with infection severity or cytopenias. Additional analyses are needed to further describe this unique group of patients.
TP53 germline pathogenic variant frequency in anaplastic rhabdomyosarcoma: A Children's Oncology Group report
Authors: Fair Douglas , Maese Luke , Chi Yueh‐Yun , Li Minjie , Hawkins Douglas S. , Venkatramani Rajkumar , Rudzinski Erin , Parham David , Teot Lisa , Malkin David , Plon Sharon E. , Li He , Sabo Aniko , Lupo Philip J. , Schiffman Joshua D. 
Published: May 2023

AbstractRhabdomyosarcoma (RMS) is a well‐described cancer in Li–Fraumeni syndrome, resulting from germline TP53 pathogenic variants (PVs). RMS exhibiting anaplasia (anRMS) are associated with a high rate of germline TP53 PVs. This study provides updated estimates of the prevalence of TP53 germline PVs in RMS (3%) and anRMS (11%) from a large cohort (n = 239) enrolled in five Children's Oncology Group (COG) clinical trials. Although the prevalence of germline TP53 PVs in patients with anRMS in this series is much lower than previously reported, this prevalence remains elevated. Germline evaluation for TP53 PVs should be strongly considered in patients with anRMS.
Central nervous system thrombosis in pediatric acute lymphoblastic leukemia in Turkey: A multicenter study
Authors: Guzelkucuk Zeliha , Karapınar Deniz Yılmaz , Gelen Sema Aylan , Tokgoz Huseyin , Ozcan Alper , Ay Yılmaz , Bahadır Aysenur , Ozbek Namik Yasar , Oren Ayse Ceyda , Ayhan Aylin Canbolat , Akyay Arzu , Akıncı Burcu , Karadas Nihal , Unuvar Aysegul , Oren Hale , Fettah Ali , Kaya Zuhre , Isık Bilgen , Eker İbrahim , Karaman Serap , Yıldırım Aysen Turedi , Orhan Mehmet Fatih , Oymak Yesim , Timur Cetin , Yazici Nalan , Simsek Ayse , Karakurt Neslihan , Toret Ersin , Evim Melike Sezgin 
Published: May 2023

AbstractBackgroundIn patients with acute lymphoblastic leukemia (ALL), the risk of thromboembolism increases due to hemostatic changes secondary to the primary disease and due to treatment‐related factors. In this multicenter study, we aimed to research the frequency of central nervous system (CNS) thrombosis occurring during treatment, hereditary and acquired risk factors, clinical and laboratory features of patients with thrombosis, treatment approaches, and thrombosis‐related mortality and morbidity rates in pediatric ALL patients.ProcedurePediatric patients who developed CNS thrombosis during ALL treatment from 2010 to 2021 were analyzed retrospectively in 25 different Pediatric Hematology Oncology centers in Türkiye. The demographic characteristics of the patients, symptoms associated with thrombosis, the stage of the leukemia treatment during thrombosis, the anticoagulant therapy applied for thrombosis, and the final status of the patients recorded through electronic medical records were determined.ResultsData from 70 patients with CNS thrombosis during treatment, out of 3968 pediatric patients with ALL, were reviewed. The incidence of CNS thrombosis was 1.8% (venous: 1.5 %; arterial: 0.03%). Among patients with CNS thrombosis, 47 had the event in the first 2 months. Low molecular weight heparin (LMWH) was the most commonly used treatment with a median of 6 months (min–max: 3–28 months). No treatment‐related complications occurred. Chronic thrombosis findings occurred in four patients (6%). In five (7%) patients who developed cerebral vein thrombosis, neurological sequelae (epilepsy and neurological deficit) remained. One patient died related to thrombosis, and the mortality rate was 1.4%.ConclusionCerebral venous thrombosis and, less frequently, cerebral arterial thrombosis may develop in patients with ALL. The incidence of CNS thrombosis is higher during induction therapy than during other courses of treatment. Therefore, patients receiving induction therapy should be monitored carefully for clinical findings suggestive of CNS thrombosis.
Feasibility of indocyanine green‐guided localization of pulmonary nodules in children with solid tumors
Authors: Abdelhafeez Abdelhafeez H. , Mothi Suraj Sarvode , Pio Luca , Mori Motomi , Santiago Teresa C. , McCarville M. Beth , Kaste Sue C. , Pappo Alberto S. , Talbot Lindsay J. , Murphy Andrew J. , Davidoff Andrew M. 
Published: May 2023

AbstractBackgroundClearing all pulmonary metastases is essential for curing pediatric solid tumors. However, intraoperative localization of such pulmonary nodules can be challenging. Therefore, an intraoperative tool that localizes pulmonary metastases is needed to improve diagnostic and therapeutic resections. Indocyanine green (ICG) real‐time fluorescence imaging is used for this purpose in adult solid tumors, but its utility in pediatric solid tumors has not been determined.MethodsA single‐center, open‐label, nonrandomized, prospective clinical trial (NCT04084067) was conducted to assess the ability of ICG to localize pulmonary metastases of pediatric solid tumors. Patients with pulmonary lesions who required resection, either for therapeutic or diagnostic intent, were included. Patients received a 15‐minute intravenous infusion of ICG (1.5 mg/kg), and pulmonary metastasectomy was performed the following day. A near‐infrared spectroscopy iridium system was optimized to detect ICG, and all procedures were photo‐documented and recorded.ResultsICG‐guided pulmonary metastasectomies were performed in 12 patients (median age: 10.5 years). A total of 79 nodules were visualized, 13 of which were not detected by preoperative imaging. Histologic examination confirmed the following histologies: hepatoblastoma (n = 3), osteosarcoma (n = 2), and one each of rhabdomyosarcoma, Ewing sarcoma, inflammatory myofibroblastic tumor, atypical cartilaginous tumor, neuroblastoma, adrenocortical carcinoma, and papillary thyroid carcinoma. ICG guidance failed to localize pulmonary metastases in five (42%) patients who had inflammatory myofibroblastic tumor, atypical cartilaginous tumor, neuroblastoma, adrenocortical carcinoma, or papillary thyroid carcinoma.ConclusionsICG‐guided identification of pulmonary nodules is not feasible for all pediatric solid tumors. However, it may localize most metastatic hepatic tumors and high‐grade sarcomas in children.
The impact of social and emotional learning on students' bullying behavior: Serial mediation of social and emotional competence and peer relationship
Authors: You Yushi , Zhang Siyi , Zhang Wanying , Mao Yaqing 
Published: May 2023

AbstractSocial and emotional learning (SEL) has gradually implemented in Chinese schools and is considered as an effective way to improve students' performance. This research aimed to study the influence of SEL on students' bullying behavior, and the role that social and emotional competence (SEC) and peer relationship play in SEL and students' bullying. The participants were 2049 students in primary and secondary schools in Beijing, China. SEM was used to examine the mediating role of SEC and peer relationship. The study found that SEL can significantly predict students' bullying behavior. In addition, SEC and peer relationship sequentially mediate the relationship between SEL and students' bullying behavior.
The burnout experience among teachers: A profile analysis
Authors: Mota Ana Isabel , Lopes João , Oliveira Célia 
Published: May 2023

AbstractThe burnout syndrome is a public health problem and is considered a subjective experience, which depends on the interpretation and evaluation individuals make of their work. In the educational context, the causes and consequences of burnout in teachers are multiple. The aim of this study is to explore the profiles of teachers with burnout and teachers without burnout in terms of (i) cognitive appraisal, (ii) perceived organizational justice, (iii) perception of administrative tasks, (iv) perception of students' misbehavior, and (v) perceived impact of parents' role on teachers' well‐being. A total of 1878 Portuguese teachers from primary to secondary education, 81% women and 19% men, aged between 23 and 66 years (M = 48; SD = 7.67) participated in this study. The results indicate statistically significant differences between teachers with and without burnout, although the two groups show an identical response pattern (i.e., parallel). The results also suggest that administrative tasks, distributive justice of rewards, students' misbehavior, and parents, negatively impact the teachers' well‐being, regardless of whether they are burned out or not. The threat and challenge perceptions are the variables with the most accentuated average differences between teachers of the two groups.
Children with uncontrolled asthma from economically disadvantaged neighborhoods: Needs assessment and the development of a school‐based telehealth and electronic inhaler monitoring system
Authors: Ramsey Rachelle R. , Noser Amy , McDowell Karen M. , Sherman Susan N. , Hommel Kevin A. , Guilbert Theresa W. 
Published: May 2023

AbstractBackgroundChildren from economically disadvantaged communities often encounter healthcare access barriers, increasing risk for poorly controlled asthma and subsequent healthcare utilization. This highlights the need to identify novel intervention strategies for these families.ObjectiveTo better understand the needs and treatment preferences for asthma management in children from economically disadvantaged communities and to develop a novel asthma management intervention based on an initial needs assessment and stakeholder feedback.MethodsSemistructured interviews and focus groups were conducted with 19 children (10–17 years old) with uncontrolled asthma and their caregivers, 14 school nurses, 8 primary care physicians, and three school resource coordinators from economically disadvantaged communities. Interviews and focus groups were audio‐taped and transcribed verbatim and then analyzed thematically to inform intervention development. Using stakeholder input, an intervention was developed for children with uncontrolled asthma and presented to participants for feedback to fully develop a novel intervention.ResultsThe needs assessment resulted in five themes: (1) barriers to quality asthma care, (2) poor communication across care providers, (3) problems identifying and managing symptoms and triggers among families, (4) difficulties with adherence, and (5) stigma. A proposed video‐based telehealth intervention was proposed to stakeholders who provided favorable and informative feedback for the final development of the intervention for children with uncontrolled asthma.ConclusionsStakeholder input and feedback provided information critical to the development of a multicomponent (medical and behavioral) intervention in a school setting that uses technology to facilitate care, collaboration, and communication among key stakeholders to improve asthma management for children from economically disadvantaged neighborhoods.
Multi‐spectral flare designs using both red‐ and green‐light emitters: Progress towards wavelength selectable signals
Authors: Kotter Lance N. , Bouma Richard H. B. , Groven Lori J. 
Published: May 2023

AbstractPyrotechnic flares are used extensively, with each color relating to specific information such as landing zone, enemy location, medical evacuation, or submarine location. While all current military flares are restricted to a single illumination color, progress towards a wavelength selectable signal and/or multispectral signal is of interest. In this effort, we use additive manufacturing, via direct ink write approach, to print three unique configurations with green/red light emitter compositions (GLE/RLE). Varying the infill design provides the opportunity to fire either of the base colors individually (red‐ and/or green‐light illuminant) or to fire them simultaneously to achieve a multispectral result. In this work, architecture is shown to play a critical role, and when the GLE composition is approx. 70 wt% of the overall, then a reasonable multi‐spectral result is achieved. While early, this work demonstrates that there is significant promise to optimize wavelength selectable signals via architecture achievable with additive manufacturing.
Endoplasmic reticulum stress in the adipose tissue and monocyte chemoattractant protein‐1 are involved in tacrolimus‐induced diabetes mellitus
Authors: Sun Xiaoxia , Wang Hongyang , Chi Jingwei , Che Kui , Wang Yangang 
Published: May 2023

AbstractTacrolimus is an independent risk factor for new‐onset diabetes after transplantation (NODAT). This study aimed to identify the mechanisms underlying tacrolimus‐induced NODAT. About 80 kidney‐transplant patients receiving tacrolimus were divided into NODAT and non‐NODAT groups after 1 year. Binary logistic regression was used to identify risk factors for NODAT. Insulin resistance indices were estimated using the homeostasis model assessment. The blood levels of 13 adipocytokines were measured 1 week after transplantation. A tacrolimus‐induced diabetes mouse model was used to reveal the underlying mechanisms. The cumulative NODAT incidence was 12.7% at 1 year (median, 6 months; range, 3–12 months). Tacrolimus trough levels ≥10 ng/mL during the first 3 months (odds ratio: 2.54, p = .012) were related to NODAT. Insulin resistance indices were higher in NODAT patients than in non‐NODAT patients at 3, 6, and 12 months. Monocyte chemoattractant protein (MCP)‐1 was overexpressed in blood in NODAT patients. In the animal experiments, postprandial blood glucose and insulin levels, insulin pathway protein levels in adipose tissue, MCP‐1 expression in blood and adipose tissue, and number of macrophages in adipose tissue were markedly higher in tacrolimus‐treated mice than in control mice, and these increases were dose‐dependent. The expression of endoplasmic reticulum (ER) stress proteins in adipose tissue was increased in a tacrolimus dose‐dependent manner. In conclusion, tacrolimus‐induced insulin resistance. Tacrolimus trough levels ≥10 ng/mL during the first 3 postoperative months were an independent risk factor for NODAT. ER stress and MCP‐1 underlie tacrolimus‐induced diabetes.
Development and characterization of defatted pumpkin seed meal and halloysite nanoclay composite films for food packaging
Authors: Kumar Yaghuvendra , Santhosh Ravichandran , Hoque Monjurul , Nath Debarshi , Thakur Rahul , Madhubabu Dasarigandla , Suryavanshi Vedsagar Rajesh , Singhi Harshi , Ahmed Jasim , Sarkar Preetam 
Published: May 2023

AbstractThe valorization of agricultural by‐products into sustainable packaging materials is one of the best strategies to utilize industrial waste efficiently. In this study, defatted pumpkin seed meal (DPSM) has been converted into films by impregnating selected concentrations of halloysite (HS) nanoclay (1%, 2% and 3% w/w). Various analytical techniques, including scanning electron microscopy (SEM), X‐ray diffraction (XRD), differential scanning calorimetry (DSC) and barrier property measurements, were employed to characterize the developed films. The appearance of the roughness on the surface of the films was evident from SEM micrographs upon the addition of HS. No change in the crystallinity of DPSM occurred when HS was incorporated; however, the Tg showed a variation with the loading concentration of the clay. Fourier transform infrared spectroscopy (FTIR) spectroscopy indicated that the decrease in hydrogen bonding was associated with increasing the HS concentrations. The addition of HS improved the tensile strength, stress relaxation percentage and Young's modulus, while the elongation at break was reduced at a similar condition. The biodegradability of the film was excellent within 20 days of the burying period. Overall, the developed films could be a potential candidate for sustainable food packaging.
A weakly coupled land surface analysis with SMAP radiance assimilation improves GEOS medium‐range forecasts of near‐surface air temperature and humidity
Authors: Reichle Rolf H. , Zhang Sara Q. , Kolassa Jana , Liu Qing , Todling Ricardo 
Published: May 2023

AbstractThe NASA Goddard Earth Observing System (GEOS) employs a hybrid four‐dimensional ensemble‐variational (Hybrid‐4DEnVar) atmospheric data assimilation system to provide global, near‐real time weather analysis and forecast products. This study introduces a land analysis into the GEOS Hybrid‐4DEnVar system to additionally assimilate L‐band (1.4 GHz) brightness temperature observations over land from the NASA Soil Moisture Active Passive (SMAP) satellite mission, which are highly sensitive to surface (∼0–5 cm) soil moisture. This weakly coupled land analysis impacts the simulated and forecast atmosphere through the land–atmosphere exchange processes encoded in the atmospheric model. Retrospective assimilation experiments for boreal summer 2017 were conducted with the system at 50 km horizontal resolution. The SMAP assimilation is shown to mitigate errors in screen‐level (2 m) specific humidity (q2m) and temperature (T2m), with regional reductions in the root‐mean‐square error (RMSE) of q2m and maximum daily T2m by up to 0.4 g·kg−1 and 0.3 K, respectively. These improvements are somewhat smaller than those found in a precursor study that used the atmospheric analysis in the simpler, 3‐dimensional variational (3DVar) atmospheric assimilation configuration of the current GEOS reanalysis; Hybrid‐4DEnVar provides overall better near‐surface background estimates than 3DVar and therefore leaves less room for improvement. Finally, in the Hybrid‐4DEnVar system with SMAP assimilation, forecasts of q2m and T2m have significantly improved anomaly correlation and RMSE (99% confidence) at lead times out to 5 days compared to the Hybrid‐4DEnVar system without SMAP assimilation, with medium‐range lead times extended by ∼3 hr for q2m and ∼2 hr for T2m. Slight but nevertheless significant improvements are also seen for temperature forecasts at the 925 and 850 hPa levels and lead times out to 4 days. Humidity forecasts at 925 and 850 hPa are improved out to 1.5‐day lead time with 90% confidence.
Furious lung abscess due to Parvimonas micra
Authors: Fukushima Shinnosuke , Hagiya Hideharu , Naito Hiromichi , Otsuka Fumio 
Published: May 2023

Key messageParvimonas micra commonly present in the oral cavity and intestinal tract of humans. P. micra indicating a high virulence, has the potential of forming abscess. The infection of P. micra may require surgical excision.
Do highly anthropized hydrological conditions in marshes influence fish communities according to their life‐history strategies?
Authors: Crabot Julie , Bergerot Benjamin , Bonis Anne , Gore Olivier , Mauchamp André , Paillisson Jean‐Marc 
Published: May 2023

AbstractAlterations of natural hydrology in aquatic ecosystems are known to strongly impact the community composition of different taxa. Surprisingly, literature on the potential influence of hydrology on fish community composition is still very scarce in agricultural marshes, where canals represent one of the few remaining aquatic habitats. This study is aimed to address this research gap by monitoring fish communities in independent hydrological units differing in hydrology management over a 6 years period. We predicted variable fish responses to the hydrological context according to different life‐history strategies (opportunistic, equilibrium, or periodic species). Periodic and opportunistic species were the most frequently observed. Despite differences in hydrology between canals (but little variation over years), we found that hydrology explained only a very low proportion of variation in the composition of fish communities. In particular, the flooding duration of meadows in early spring did not influence the composition of fish communities, not even the abundance of periodic species expected to rely on such temporary habitats. Instead, fish communities were more influenced by local habitat variables (aquatic vegetation cover, turbidity, tree roots, and refuges under the canal banks). The hydrological management of most hydrological units for agricultural purposes (i.e., severe flood abatement in spring and shallow water depth in canals in summer) was found to be incompatible with conservation goals to promote more diverse fish communities between hydrological units. Therefore, we call for further investigations in similar habitats covering a larger range of hydrological conditions.