bluuebunny/crossref_metadata_2025_split huggingface dataset:
Substitutional semi-rigid osteosynthesis technique for treatment of unstable pubic symphysis injuries: a biomechanical study
Authors: Berk Till , Zderic Ivan , Varga Peter , Schwarzenberg Peter , Berk Karlyn , Grüneweller Niklas , Pastor Tatjana , Halvachizadeh Sascha , Richards Geoff , Gueorguiev Boyko , Pape Hans-Christoph 
Published: August 2023

Abstract
Background/Purpose
The surgical fixation of a symphyseal diastasis in partially or fully unstable pelvic ring injuries is an important element when stabilizing the anterior pelvic ring. Currently, open reduction and internal fixation (ORIF) by means of plating represents the gold standard treatment. Advances in percutaneous fixation techniques have shown improvements in blood loss, surgery time, and scar length. Therefore, this approach should also be adopted for treatment of symphyseal injuries. The technique could be important since failure rates, following ORIF at the symphysis, remain unacceptably high. The aim of this biomechanical study was to assess a semi-rigid fixation technique for treatment of such anterior pelvic ring injuries versus current gold standards of plate osteosynthesis.

Methods
An anterior pelvic ring injury type III APC according to the Young and Burgess classification was simulated in eighteen composite pelvises, assigned to three groups (n = 6) for fixation with either a single plate, two orthogonally positioned plates, or the semi-rigid technique using an endobutton suture implant. Biomechanical testing was performed in a simulated upright standing position under progressively increasing cyclic loading at 2 Hz until failure or over 150,000 cycles. Relative movements between the bone segments were captured by motion tracking.

Results
Initial quasi-static and dynamic stiffness, as well as dynamic stiffness after 100,000 cycles, was not significantly different among the fixation techniques (p ≥ 0.054).). The outcome measures for total displacement after 20,000, 40,000, 60,000, 80,000, and 100,000 cycles were associated with significantly higher values for the suture technique versus double plating (p = 0.025), without further significant differences among the techniques (p ≥ 0.349). Number of cycles to failure and load at failure were highest for double plating (150,000 ± 0/100.0 ± 0.0 N), followed by single plating (132,282 ± 20,465/91.1 ± 10.2 N), and the suture technique (116,088 ± 12,169/83.0 ± 6.1 N), with significantly lower values in the latter compared to the former (p = 0.002) and no further significant differences among the techniques (p ≥ 0.329).

Conclusion
From a biomechanical perspective, the semi-rigid technique for fixation of unstable pubic symphysis injuries demonstrated promising results with moderate to inferior behaviour compared to standard plating techniques regarding stiffness, cycles to failure and load at failure. This knowledge could lay the foundation for realization of further studies with larger sample sizes, focusing on the stabilization of the anterior pelvic ring.
The absence of reporting standards and a lack of objective, performance-based outcomes following intramedullary nailing of tibial shaft fractures: findings from a scoping review into 179 articles
Authors: Thwaites Simon , Abrahams John , Thewlis Dominic , Rickman Mark 
Published: August 2023

Abstract
Purpose
This scoping review was conducted to summarise the outcome tools reported in the assessment of tibial shaft fractures treated with intramedullary (IM) nailing, with a key focus on knee pain and function, and performance-based outcomes.

Methods
PubMed and Embase databases were searched on May 31, 2023. All study designs and populations were included, including ex vivo studies without fracture. Studies with only open or intra-articular fractures, or other fracture fixation, were excluded. Reported outcome tools and pertinent study characteristics were extracted and summarised.

Results
Of 488 articles identified, 179 met the inclusion criteria. For in vivo studies (n = 152), there were 13,705 fractures; the IM nailing approach not described for 30% of these. There were 133 unique patient outcomes, with a binary assessment of knee pain (29% of studies) and Lysholm score (21%) most common. Only 10/152 (7%) in vivo studies included an objective, performance-based measure of knee function. Fracture union was most frequent (52%) of 81 different clinical outcomes. For ex vivo studies (n = 29), there were 408 tibias included, with nail insertion location most prevalent (66% of studies) of 34 reported outcomes.

Conclusion
The heterogeneity of outcome tools reported limits comparison between studies and the most commonly reported patient outcomes may not be the most appropriate. Future studies should report the IM nailing approach and consider capturing both patient-reported and performance-based outcomes to help inform surgical decision making.
Legal imagination and the US project of globalising the free flow of data
Authors: Brännström Leila , Gunneflo Markus , Noll Gregor , Parsa Amin 
Published: August 2023

AbstractToday, the US pursues the global capture of data (understood as a significant engine of growth) by way of bi- and plurilateral trade agreements. However, the project of securing the global free flow of data has been pursued ever since the dawn of digital telecommunication in the 1960s and the US has made significant legal efforts to institutionalise it. These efforts have two phases: In the first 1970s and 80s “freedom of information” phase, the legal justification (and contestation) of the global free flow of data hinged on imagining data as information, and its exchange as a practice of liberty. The second phase began in the late 1990s and continues today. In this phase, the free flow of data is aligned with a free-trade agenda in the context of first e-commerce and, starting in the 2000s, through attempts at creating a global public domain of personal data for the platform economy. The global free flow of data is an intrinsic aspect of informational capitalism. Assuming a constitutive, but not commanding role for law in informational capitalism, we conclude that the US attempt at ensuring free flow for its informational corporations is neither an entirely contingent nor a necessary outcome. It is a product of legal imagination.
Roles of depth, current speed, and benthic cover in shaping gorgonian assemblages at the Palm Islands (Great Barrier Reef)
Authors: Panero Marta , Galbraith G. F. , Srinivasan M. , Jones G. P. 
Published: August 2023

AbstractGorgonians are a diverse and conspicuous component of coral reef ecosystems, providing habitat structure that supports unique assemblages of fishes and invertebrates. Evaluating their overall importance as ecological engineers requires an understanding of their spatial patterns of distribution, abundance and assemblage composition, and the biophysical factors that drive these patterns. No baseline data are available on the spatial patterns of distribution of gorgonians for the Great Barrier Reef. In this study, we quantified the abundance, genera richness, and composition of gorgonian assemblages using video surveys at three depths (5, 10, and 15 m) at 16 locations at the Palm Islands, an inshore island group in the central Great Barrier Reef. We compared gorgonian abundance and genera richness between depths and assessed the role of benthic habitat in structuring gorgonian communities. We also conducted a preliminary investigation of the potential role of water currents in driving gorgonian spatial patterns in the Palm Islands, using in situ current meters. Gorgonian abundance and genera richness consistently increased with depth, although the magnitude of the depth effect varied among locations. Abundance increased with increasing percent cover of rubble and conversely declined with increasing cover of hard corals. The composition of gorgonian assemblages also varied among depths, with whip (Junceella, Viminella) and fan (Acanthogorgia, Anthogorgia, Annella) growth forms being dominant at depths of 5 and 10 m, and branching (Dichotella, Icilogorgia) and candelabrum (Ctenocella) forms being dominant at 15 m. The shallow gorgonian assemblage was associated with high coral cover, whilst the deeper assemblage was associated with high per cent cover of rubble, turf and/or macroalgae. This study highlighted that the abundance, diversity, and composition of gorgonian assemblages on coral reefs in the Palm Islands are determined by a range of biophysical factors linked to depth. Further work is required to isolate the primary drivers of these depth-related effects and evaluate their relative importance.
The structure of cognitive strategies for wayfinding decisions
Authors: Bock Otmar , Huang Ju-Yi , Onur Oezguer A. , Memmert Daniel 
Published: August 2023

AbstractLiterature proposes five distinct cognitive strategies for wayfinding decisions at intersections. Our study investigates whether those strategies rely on a generalized decision-making process, on two frame-specific processes—one in an egocentric and the other in an allocentric spatial reference frame, and/or on five strategy-specific processes. Participants took six trips along a prescribed route through five virtual mazes, each designed for decision-making by a particular strategy. We found that wayfinding accuracy on trips through a given maze correlated significantly with the accuracy on trips through another maze that was designed for a different reference frame (rbetween-frames = 0.20). Correlations were not significantly higher if the other maze was designed for the same reference frame (rwithin-frames = 0.19). However, correlations between trips through the same maze were significantly higher than those between trips through different mazes that were designed for the same reference frame (rwithin-maze = 0.52). We conclude that wayfinding decisions were based on a generalized cognitive process, as well as on strategy-specific processes, while the role of frame-specific processes—if any—was relatively smaller. Thus, the well-established dichotomy of egocentric versus allocentric spatial representations did not translate into a similar, observable dichotomy of decision-making.
Leitlinie S1 für das Management postviraler Zustände am Beispiel Post-COVID-19
Authors: Rabady Susanne , Hoffmann Kathryn , Aigner Martin , Altenberger Johann , Brose Markus , Costa Ursula , Denk-Linnert Doris-Maria , Gruber Samuel , Götzinger Florian , Helbok Raimund , Hüfner Katharina , Koczulla Rembert , Kurz Katharina , Lamprecht Bernd , Leis Stefan , Löffler Judith , Müller Christian A. , Rittmannsberger Hans , Rommer Paulus S. , Sator Paul , Strenger Volker , Struhal Walter , Untersmayr Eva , Vonbank Karin , Wancata Johannes , Weber Thomas , Wendler Maria , Zwick Ralf-Harun 
Published: August 2023

ZusammenfassungDie vorliegende Leitlinie S1 ist die Aktualisierung und Weiterentwicklung der Leitlinie S1 Long COVID: Differenzialdiagnostik und Behandlungsstrategien. Sie fasst den Stand der Kenntnis zu postviralen Zuständen anhand des Beispiels Long/Post COVID zum Zeitpunkt des Redaktionsschlusses zusammen. Aufgrund der starken Dynamik der Wissensentwicklung versteht sie sich als „living guideline“. Der Schwerpunkt liegt auf der praktischen Anwendbarkeit auf der Ebene der hausärztlichen Primärversorgung, die als geeignete Stelle für den Erstzutritt und für die primäre Betreuung und Behandlung verstanden wird. Die Leitlinie gibt Empfehlungen zum Versorgungsgang, zu Differenzialdiagnostik der häufigsten Symptome, die in der Folge einer Infektion wie mit SARS-CoV‑2 auftreten können, zu therapeutischen Optionen, zu Patient:innenführung und -betreuung sowie zur Wiedereingliederung in den Alltag und zur Rehabilitation. Entsprechend des Krankheitsbildes ist die Leitlinie in einem interdisziplinären und interprofessionellen Prozess entstanden und gibt Empfehlungen zu Schnittstellen und Kooperationsmöglichkeiten.
Hyperpolarized Multi-organ Spectroscopy of Liver and Brain Using 1-13C-Pyruvate Enhanced via Parahydrogen
Authors: Hune Theresa L. K. , Mamone Salvatore , Schmidt Andreas B. , Mahú Inês , D’Apolito Natascha , Wiedermann Dirk , Brüning Jens , Glöggler Stefan 
Published: August 2023

AbstractHyperpolarization in nuclear magnetic resonance boosts the signals by several orders of magnitude. Using the singlet spin order of parahydrogen to create large non-equilibrium spin polarization is a fast approach to obtain hyperpolarized metabolites in seconds. In recent years, it has attracted particular interest in the field of biomedicine because signal-enhanced and 13C-enriched metabolites allow for real-time metabolic investigations in combination with imaging in vivo. With this, metabolism can be traced and characterized with spatial selectivity in the body. Here, we introduce a method to use signal-enhanced metabolites to study multiple organs in separate injections to obtain real-time kinetics in vivo of these organs. Using hyperpolarized 1-13C-pyruvate, we measured the kinetics of the conversion from pyruvate to lactate in the brain and the liver of mice. This we did by injecting the hyperpolarized pyruvate two times within half an hour and using each injection to measure the spectra of one region of interest. Organ cross-talk and especially how different organs affect each other in diseases is of major interest and poorly understood, because of the high complexity of biological systems. With the proof-of-principle study provided here, we are introducing a new tool to study organ-related interaction in vivo. It allows the characterization of different organs of the same animal within half an hour, which is enabled by the fast signal enhancement achieved with parahydrogen.
Mesostructural changes in cellulose within wood cell wall upon hydrothermal treatment at 200 °C
Authors: Kuribayashi Tomoko , Ogawa Yu , Morfin Isabelle , Matsumoto Yuji , Nishiyama Yoshiharu 
Published: August 2023

AbstractHydrothermal treatment between 150 °C and 230 °C is widely used in wood processing, from the steam treatment of timber for better dimensional stability and durability to the pretreatment for enzymatic saccharification and chemical pulping. Understanding the ultrastructural changes of wood cell walls through hydrothermal treatments is crucial for controlling and optimizing these hydrothermal treatment-based processes. Here, we studied the ultrastructure of wood cell walls of 24 hardwood species using simultaneous small- and wide-angle X-ray scattering measurements before and after the hydrothermal treatment at 200 °C. Most hardwoods show similar equatorial scattering features, representing the structure in the cross-section of the cell walls. In a water-saturated native state, there is a prominent correlation peak between 0.1 and 0.2 Å−1 and a second peak between 0.2 and 0.4 Å−1. The hydrothermal treatment above 160 ˚C drastically altered the structure at this nanometric scale: the two native correlation peaks disappeared, coincident with a buildup of a correlation peak in the 0.03–0.04 Å−1 range. The hydrothermal treatment likely removed the cell wall matrix component between the microfibrils through autohydrolysis and phase separation, leading to the collapse of microfibrils with each other in the normal wood. In cellulose-rich cell walls, such as the G-layer in tension wood, cellulose microfibrils are already collated in the native state.
The effect of sulfate half-ester groups on the mechanical performance of cellulose nanocrystal-natural rubber composites
Authors: Imiete Iikpoemugh Elo , Giannini Luca , Tadiello Luciano , Orlandi Marco , Zoia Luca 
Published: August 2023

AbstractCellulose nanocrystals (CNCs) are commercially produced via hydrolysis by sulfuric acid, resulting in the formation of sulfate half-ester groups on the surface of the nanoparticles. The sulfate half-esters promote good colloidal stability but could affect other properties of the CNCs. To study the impact of the sulfate half-ester groups on the mechanical properties of CNC-natural rubber composites, sodium hydroxide was used as a desulfation agent to partially remove this chemical functionality. Mechanical characterizations revealed that CNCs conferred outstanding mechanical properties to the composites. At the same time, differences in the amounts of sulfate half-ester groups had remarkable consequences for the tensile strength and the dynamic mechanical properties, while the vulcanization properties of the composites were less influenced.
i-Align: an interpretable knowledge graph alignment model
Authors: Trisedya Bayu Distiawan , Salim Flora D. , Chan Jeffrey , Spina Damiano , Scholer Falk , Sanderson Mark 
Published: August 2023

AbstractKnowledge graphs (KGs) are becoming essential resources for many downstream applications. However, their incompleteness may limit their potential. Thus, continuous curation is needed to mitigate this problem. One of the strategies to address this problem is KG alignment, i.e., forming a more complete KG by merging two or more KGs. This paper proposes i-Align, an interpretable KG alignment model. Unlike the existing KG alignment models, i-Align provides an explanation for each alignment prediction while maintaining high alignment performance. Experts can use the explanation to check the correctness of the alignment prediction. Thus, the high quality of a KG can be maintained during the curation process (e.g., the merging process of two KGs). To this end, a novel Transformer-based Graph Encoder (Trans-GE) is proposed as a key component of i-Align for aggregating information from entities’ neighbors (structures). Trans-GE uses Edge-gated Attention that combines the adjacency matrix and the self-attention matrix to learn a gating mechanism to control the information aggregation from the neighboring entities. It also uses historical embeddings, allowing Trans-GE to be trained over mini-batches, or smaller sub-graphs, to address the scalability issue when encoding a large KG. Another component of i-Align is a Transformer encoder for aggregating entities’ attributes. This way, i-Align can generate explanations in the form of a set of the most influential attributes/neighbors based on attention weights. Extensive experiments are conducted to show the power of i-Align. The experiments include several aspects, such as the model’s effectiveness for aligning KGs, the quality of the generated explanations, and its practicality for aligning large KGs. The results show the effectiveness of i-Align in these aspects.
Cytotoxicity of poly-guanidine in medulloblastoma cell lines
Authors: Gallo-Oller Gabriel , de Ståhl Teresita Díaz , Alaiya Ayodele , Nilsson Sten , Holmberg Anders R. , Márquez-Méndez Marcela 
Published: August 2023

SummaryMedulloblastoma (MB) is the most common pediatric brain tumor. The therapy frequently causes serious side effects, and new selective therapies are needed. MB expresses hyper sialylation, a possible target for selective therapy. The cytotoxic efficacy of a poly guanidine conjugate (GuaDex) incubated with medulloblastoma cell cultures (DAOY and MB-LU-181) was investigated. The cells were incubated with 0.05–8 µM GuaDex from 15 min to 72 h. A fluorometric cytotoxicity assay (FMCA) measured the cytotoxicity. Labeled GuaDex was used to study tumor cell interaction. FITC-label Sambucus nigra confirmed high expression of sialic acid (Sia). Immunofluorescence microscopy was used to visualize the cell F-actin and microtubules. The cell interactions were studied by confocal and fluorescence microscopy. Annexin-V assay was used to detect apoptosis. Cell cycle analysis was done by DNA content determination. A wound-healing migration assay determined the effects on the migratory ability of DAOY cells after GuaDex treatment. IC50 for GuaDex was 223.4 -281.1 nM. FMCA showed potent growth inhibition on DAOY and MB-LU-181 cells at 5 uM GuaDex after 4 h of incubation. GuaDex treatment induced G2/M phase cell cycle arrest. S. nigra FITC-label lectin confirmed high expression of Sia on DAOY medulloblastoma cells. The GuaDex treatment polymerized the cytoskeleton (actin filaments and microtubules) and bound to DNA, inducing condensation. The Annexin V assay results were negative. Cell migration was inhibited at 0.5 µM GuaDex concentration after 24 h of incubation. GuaDex showed potent cytotoxicity and invasion-inhibitory effects on medulloblastoma cells at low micromolar concentrations. GuaDex efficacy was significant and warrants further studies.
Sloppy Models, Renormalization Group Realism, and the Success of Science
Authors: Freeborn David 
Published: August 2023

Abstract
The “sloppy models” program originated in systems biology, but has seen applications across a range of fields. Sloppy models are dependent on a large number of parameters, but highly insensitive to the vast majority of parameter combinations. Sloppy models proponents claim that the program may explain the success of science. I argue that the sloppy models program can at best provide a very partial explanation. Drawing a parallel with renormalization group realism, I argue that it would only give us grounds for a minimal kind of scientific realism. Nonetheless, the program can offer certain epistemic virtues.
Effect of ball milling time on the formation and thermal properties of Ag2Se and Cu2Se compounds
Authors: Tarani Evangelia , Stathokostopoulos Dimitrios , Karfaridis Dimitrios , Malletzidou Lamprini , Sfampa Ioanna K. , Stergioudi Fani , Maliaris Georgios , Michailidis Nikolaos , Chrissafis Konstantinos , Vourlias George 
Published: August 2023

AbstractThe thermoelectric materials community has made significant progress on nanostructured and processable materials to improve efficiency and flexibility, reducing manufacturing costs. Selenide compounds, such as Ag2Se and Cu2Se, have received a lot of attention because of their promising capabilities in thermoelectric applications. Additionally, Se is significantly more abundant than Te, with approximately ten times higher availability. High-energy ball milling (HEBM) process is a powerful solid-state synthesis/powder mechanical alloying method. The objective of this work is to form selenide compounds at different milling times (1–20 h) by HEBM process. The structural characterization of the compounds was studied by X-ray Diffraction and X-ray Photoelectron Spectroscopy, while the thermal stability of the prepared samples was examined by Thermogravimetric Analysis. The experimental results show that the Ag2Se sample synthesized at 20 h presents lower thermal stability because of the higher specific surface area and the increased porosity as a result of the hardening effect. Additionally, Cu2Se presents Cu2O(SeO3) as the main phase at low temperatures, while at higher temperatures, CuO is the dominant phase. Therefore, as the heating temperature increases, there is a complete evaporation of Se and a conversion of the remaining copper into copper oxide. The present study demonstrates a simple method for the synthesis of Ag2Se and Cu2Se thermoelectric materials with high oxidation resistance.