bluuebunny/crossref_metadata_2025_split huggingface dataset:
Early Detection and Progression of Subclinical Atherosclerosis in Psoriasis (EDSAP): protocol for an observational, single-centre, prospective cohort study
Authors: Abbad-Jaime de Aragón Carlota , Berna-Rico Emilio , Ballester-Martinez María Asunción , Jaén Pedro , Solís Jorge , Barderas María G , Fernández-Friera Leticia , N Mehta Nehal , Gelfand Joel M , González-Cantero Álvaro 
Published: September 2023

IntroductionLife expectancy of patients with psoriasis is reduced by 4–5 years due to cardiovascular disease with an increased risk of myocardial infarction at an earlier age compared with the general population. This increased risk is independent of traditional cardiovascular risk factors and higher in moderate-to-severe forms of psoriasis. Inflammation may play a key role in the development of atherosclerosis in these patients.Methods and analysisA prospective cohort study, Early Detection and Progression of Subclinical Atherosclerosis in Psoriasis (EDSAP), was initiated in January 2020 to investigate the presence and progression of subclinical atherosclerosis in patients with psoriasis. 120 patients aged 30–65 years and eligible for biological treatment have been recruited at Hospital Ramón y Cajal in Madrid, Spain. Patients undergo a baseline visit, and 1-year follow-up visit after starting biological therapy. Each visit includes: assessment of cardiovascular risk factors, screening for subclinical atherosclerosis by two-dimensional/three-dimensional ultrasound of carotid and femoral arteries, cardiac CT of coronary arteries and blood sampling. All baseline visits were completed by December 2022, and the remaining follow-up visits will be concluded by the end of 2023. The EDSAP study aims to identify new molecular and imaging markers associated with the presence of atherosclerosis and its progression in a chronic inflammatory state such as psoriasis. This has the potential to: (1) help improve primary cardiovascular prevention strategies in these patients; (2) understand the effect of biological drugs on the cardiovascular system; and (3) serve as a model for understanding atherosclerosis in other chronic inflammatory diseases.Ethics and disseminationThe study protocol has been approved by the Institutional Review Board of the Hospital Ramón y Cajal in Madrid. We will present our findings at national and international congresses, and peer-reviewed journals.Trial Registration numberNCT05858099.
Knowledge on gestational diabetes mellitus and associated factors among pregnant women attending antenatal care clinics of North Shewa zone public hospitals, Oromia region, Central Ethiopia: a cross-sectional study
Authors: Dissassa Hiwot Dejene , Tufa Derara Girma , Geleta Leta Adugna , Dabalo Yohannes Amsalu , Oyato Befekadu Tesfaye 
Published: September 2023

BackgroundGlobally, the prevalence of gestational diabetes mellitus (GDM) is currently rising. Assessing GDM knowledge and taking various public health actions will help pregnant women know more about the condition, resulting in its prevention.ObjectiveTo assess pregnant women’s knowledge of GDM and associated factors at antenatal care clinics of public hospitals in the North Shewa zone, Oromia region, Central Ethiopia.DesignCross-sectional study.SettingFive public hospitals of North Shewa zone, Oromia regional state, Central Ethiopia.ParticipantsA total of 417 pregnant women.MethodsA face-to-face interview was conducted. A 13-items tool was used to measure GDM knowledge. Multivariable binary logistic regression was fitted to identify factors associated with the knowledge of GDM. The adjusted OR (AOR) with 95% CI and a p<0.05 was used to determine statistical significance.ResultsOverall, 48% (95% CI 43.4% to 52.8%) of pregnant women had sufficient knowledge about GDM. The level of sufficient knowledge for GDM risk factors, screening/treatment and its consequences were 48%, 54.4% and 99%, respectively. Age group 15–24 years (AOR 3.49, 95% CI 1.05 to 11.59), attending secondary and above education (AOR 4.27, 95% CI 1.29 to 14.070, women whose partners attended primary school (AOR 3.83, 95% CI 1.36 to 10.78), history of GDM (AOR 3.36, 95% CI 1.68 to 6.71), history of hypertension (AOR 2.42, 95% CI 1.21 to 4.84), receiving preconception care (AOR 3.02, 95% CI 1.74 to 5.22) and being multigravida (AOR 3.19, 95% CI 1.52 to 6.67) were factors significantly associated with sufficient knowledge about GDM.ConclusionOverall, more than half of pregnant women have insufficient knowledge about GDM. Significant association between GDM knowledge and women’s age, women’s and partners’ educational status, preconception care, history of GDM and hypertension, and the number of pregnancies were detected. Therefore, to increase pregnant women’s GDM knowledge, health education programmes in the community and healthcare facilities should target the identified factors.
Automated choice for the best renormalization scheme in BSM models
Authors: Heinemeyer S. , von der Pahlen F. 
Published: September 2023

AbstractThe explorations of models beyond the Standard Model (BSM) naturally involve scans over the unknown BSM parameters. On the other hand, high precision predictions require calculations at the loop-level and thus a renormalization of (some of) the BSM parameters. Often many choices are possible for the renormalization scheme (RS). This concerns the choice of the set of to-be-renormalized parameters out of a larger set of BSM parameters, but can also concern the type of renormalization condition which is chosen for a specific parameter. A given RS can be well suited to yield “stable” and “well behaved” higher-order corrections in one part of the BSM parameter space, but can fail completely in other parts, which may not even be noticed numerically if an isolated parameter point is investigated, or when the higher-order BSM calculations are performed in an automated, not supervised set-up. Consequently, the (automated) exploration of BSM models requires a choice of a good RSbeforethe calculation is performed. We propose a new method with which such a choice can be performed. We demonstrate the feasibility of our new method in the chargino/neutralino sector of the Minimal Supersymmetric Standard Model (MSSM), but stress the general applicability of our method to all types of BSM models.
Charged particles motion and quasiperiodic oscillation in Simpson–Visser spacetime in the presence of external magnetic fields
Authors: Vrba Jaroslav , Rayimbaev Javlon , Stuchlik Zdenek , Ahmedov Bobomurat 
Published: September 2023

AbstractThe present work is devoted to the study of the dynamics of charged particles around Simpson–Visser black holes (with the length parameter $$ l\le $$

l
≤

2) and wormholes ($$l>2$$

l
>
2

) immersed in an external asymptotically uniform magnetic field. To do this, first, we solve the Maxwell equation for 4-potentials of the electromagnetic field and show that the difference between the numerical solution and Wald’s solution is small enough to neglect it, which may allow us to use the solution obtained by Wald. We also study fundamental frequencies of in the vertical and radial oscillations of charged particles around circular stable orbits around the magnetized black hole. The effects of the magnetic interaction and length parameters on the fundamental frequencies. We investigate the quasiperiodic oscillations (QPOs) around the black hole in relativistic precession and epicyclic resonance models. It is also shown that the combined effects of magnetic interaction for negatively charged particles and length parameters can mimic the spacetime effects of the Schwarzschild black hole compensating for their effects, as well as the spin of rotating Kerr black holes. The distance between an orbit where a QPO is generated with the ratio of upper and lower frequencies 3: 2 and innermost stable circular orbits is also studied. It is found that the QPO orbits are very close to ISCO in the RP model at $$l<2$$

l
<
2

. This implies that the obtained result helps to determine the ISCO around black holes. We also study the applications of observed QPOs around stellar-mass black holes in microquasars and supermassive black holes.
Comparing mathematical modeling approaches for compact objects: vanishing complexity and embedding class one approaches in spherically symmetric systems with static background
Authors: Gedela Satyanarayana , Bisht Ravindra K. 
Published: September 2023

AbstractThis study delves into the realm of solving Einstein’s field equations within the framework of general relativity. In this paper, we present an exact solution derived through the vanishing complexity approach and offer a comparative analysis with the established embedding class one approach. This exploration sheds light on the efficacy and validity of these methods in generating solutions for Einstein’s field equations. Our study involves a comprehensive exploration of several key parameters, encompassing thermodynamic factors, causality conditions, stability evaluations, as well as analyses of the mass function. Based on our findings, it can be suggested that the vanishing complexity approach could serve as a viable alternative method to the embedding class one approach for the derivation of exact solutions of Einstein’s field equations.
Pan-Turkism in Action? Turkic Nationalists, Nazi Germany and Turkey During World War ii
Authors: Lüdke Tilman 
Published: September 2023

Abstract
For Pan-Turkists, the Nazi German attack on the Soviet Union in June 1941 seemed to offer a chance for the liberation of Turkic peoples from Soviet domination. Consequently, they attempted to win over both the Turkish and the Nazi German governments to support their aims. Although active Pan-Turkist policies—entailing entry into the war on the German side—were intensively debated during 1941 and 1942, Turkey ultimately suppressed the Pan-Turkist movement for fear of alienating the Soviet neighbour and provoking Soviet retaliation. The Germans saw themselves confronted with collaboration offers by Pan-Turkist activists from the Soviet Union. Such collaboration provided the increasingly hard-pressed Germans with large numbers of volunteers, but indecision and the clashes of racist and imperialist Nazi ideologies with the interests of the peoples living under Soviet authority ultimately rendered this cooperation ineffective.
Tacitus’ Critique of Republicanism in His Germania
Authors: Cole Thomas J.B. 
Published: September 2023

Abstract
Although Tacitus began his writing career during the Principate at the end of the first century CE, the dominant approach to thinking about political life was still guided by Republicanism, a constellation of concepts from the mid-first century BCE Roman Republic. Republicanism held that there was only one type of monarchy and that it necessarily precluded libertas. Tacitus, who was living under different iterations of monopolistic power in the Principate, questions this tenet by examining various Germanic tribes. The Germania explores different types of monarchical arrangements, showing that monarchy is not a one-size-fits-all form and that there are significant political differences among the Germanic monarchies, some of which preserve libertas. In this examination, he highlights the inapplicability of Republicanism to a system as dynamic as the Principate.
Does Preoperative Weight Loss Affect Outcomes After Major Liver Resection? Analysis of a National Database
Authors: Nordan Taylor , Ahmad Shahzaib , Karagozian Raffi , Schnelldorfer Thomas , Aziz Hassan 
Published: September 2023

Introduction: The association between unintentional weight loss (WL) and outcomes after major hepatectomy for malignancy remains unclear. Methods: This retrospective cohort study reviewed the 2014-2019 NSQIP database of all patients who underwent major liver resections. The patients were categorized into two groups based on their history of weight loss. The primary outcome measure was the 30-day mortality. The secondary outcome was 30-day in-hospital complications. Results: In total, 384 patients had a history of preoperative weight loss. Preoperative WL was an independent predictor of septic shock (OR, 2.44; CI: 1.61, 3.69), bile leak (OR: 1.96; CI: 1.51, 2.55), and grade C liver failure (OR: 2.57; CI: 1.64, 4.01). However, preoperative WL was not a significant predictor of perioperative mortality (OR: 1.38; CI: 0.82, 2.32). Conclusion: The study found higher morbidity rates in patients undergoing liver resection with a history of weight loss. Further validation with prospective weight monitoring is needed to validate as a prognostic marker in patients undergoing hepatectomy. In addition, weight changes can help guide multidisciplinary decision-making in treating patients undergoing hepatectomy.
Energy absorption capability of laterally loaded glass/epoxy tubular components containing halloysite nanotubes
Authors: Awd Allah Mahmoud M. , Abd El-baky Marwa A. , Alshahrani Hassan , Sebaey Tamer A. , Hegazy Dalia A. 
Published: September 2023

The crashworthiness capability of laterally loaded glass/epoxy (GFRE) tubular components containing halloysite nanotubes (HNTs) was explored in this article. GFRE components filled with 0, 1, 2, 3, and 4 weight percent (wt.%) of HNTs were created using wet-wrapping by hand lay-up technique. For the laterally loaded tubes, the crushing load and the energy absorption versus displacement responses were presented. In addition, distortion histories were tracked. The crashworthiness analysis was carried out by evaluating different indicators, i.e., initial crush load [Formula: see text], average crush load ([Formula: see text]), crush load efficiency (CFE), energy absorption (U), and specific absorbed energy (SEA). Two parameters of the Weibull distribution were employed to assess the experimental findings statistically. In addition, mathematical regression models were built to predict the energy absorption indicators. Experimental results demonstrated that an unfilled tube demonstrated the largest CFE of 1.84, while the maximum [Formula: see text] was demonstrated by a tube filled with 2 wt.% of HNTs with a value of 3.70 kN. Additionally, the tube filled with 4 wt.% of HNTs represents the extremes [Formula: see text], U, and SEA with values of 4.26 kN, 128.82 J, and 3.84 J/g, respectively. Due to their improved crashworthiness characteristics, GFRE filled with 4 wt.% of HNTs is suitable for use as a crashworthy device in automobiles.
Intracapsular Enucleation of Brachial Plexus Schwannoma With Intraoperative Neuromonitoring: A Case Series Study and a Review of Literature
Authors: Shi Juan , He Kai-Xuan , Dong Yan-Bo , Liu Yu-He , Lu Cheng , Li Wan-Xin 
Published: September 2023

Objective: Brachial plexus schwannoma (BPS) is a rare clinical entity that poses a significant challenge for head and neck surgeons due to its neuroanatomical complexity and potential severe complications, such as major motor or sensory neurological deficits or pain of the corresponding upper extremity. This article summarizes our experience in its diagnosis and intracapsular enucleation with intraoperative neuromonitoring (INM). Methods: A retrospective review of BPS cases treated at our tertiary medical institution was conducted between April 2020 and May 2023. The clinical and demographic data were retrieved from case notes. Results: Totally, 3 cases were included. All 3 patients were male, aged 43 to 54 years (median age = 52). The presenting symptom was a palpable supraclavicular mass in all these cases (2 on the left side and 1 on the right side). Neuromonitoring was performed with a 4-channel nerve integrity monitor, with the electrodes placed in the upper arm and forearm muscles, as demonstrated in the literature. After exposing the mass and identifying its origin from the brachial plexus, a unipolar stimulating probe was used to stimulate the tumor surface or the nerves with a 1.0-mA current, and a longitudinal incision into the tumor capsule was made along a carefully mapped line with no INM response. Then the mass was carefully exposed and meticulously dissected from its capsule to achieve an intact enucleation. Immediate postoperative neurological deficit was documented in Case 1 as a mild grasping weakness. The recovery of the other 2 patients was uneventful. The follow-up duration was 7 to 38 months (median = 8 months). The minor motor deficit of Case 1 recovered completely 1 month after surgery. No recurrence of BPS was observed. Conclusions: Intracapsular enucleation with INM could result in complete removal of BPS and minimal postoperative neurological deficit, whose recovery was quick and satisfactory.
Comparative efficacy of quetiapine by dose and formulation for psychosis in schizophrenia: A systematic review and dose–response model-based network meta-analysis
Authors: Terao Itsuki , Yokoi Asato , Fukushima Hirotaka 
Published: September 2023

Background: Quetiapine has varied dose ranges and immediate-(QTP-IR) and extended-release (QTP-ER) formulations. Aims: We hypothesized that QTP-IR is inferior to QTP-ER at any dose in efficacy for the acute treatment in schizophrenia and tested using a dose–response model-based network meta-analysis (NMA). Methods: We searched PubMed, the Cochrane Library, CINHAL, and ClinicalTrials.gov for randomized placebo-controlled trials comparing QTP-IR and/or QTP-ER for acute psychosis in patients with schizophrenia up to September 21, 2022. A random effect Bayesian dose–response model-based NMA was performed to compare the dose–response relationships between QTP-IR and QTP-ER. Results: The relationship between doses and antipsychotic effects was partially bell-shaped for QTP-IR but not for QTP-ER. The respective peak effect dose was 279.7 mg for QTP-IR and 557.2 mg for QTP-ER, with no significant difference in peak effect. QTP-IR ranging from 100 to 300 mg were significantly superior to QTP-ER at the same doses. In addition, QTP-IR ranging from 100 to 400 mg were significantly better than placebo, whereas QTP-ER ranging from 500 to 800 mg were significantly more effective than placebo. Moreover, QTP-IR 600 mg was significantly less effective than QTP-ER at the same dose. Furthermore, QTP-IR 700 mg was significantly superior to placebo, but significantly inferior to QTP-ER 600 mg. Conclusions: QTP-IR may reach comparable peak responses and exhibit enhanced antipsychotic effects at lower doses than QTP-ER; the converse may be true at relatively high doses. Collectively, we propose a novel strategy to enhance the efficacy of QTP administration.
Exploring the efficacy and safety of a novel standardized ashwagandha (Withania somnifera) root extract (Witholytin®) in adults experiencing high stress and fatigue in a randomized, double-blind, placebo-controlled trial
Authors: Smith Stephen J , Lopresti Adrian L , Fairchild Timothy J 
Published: September 2023

Background: Stress is a state of homeostasis in the body being challenged, resulting in a systemic response. It has become more prevalent in recent years and affects mental and physical health. Aims: Evaluate the effects of ashwagandha on stress, fatigue, and sex hormones in overweight or mildly obese men and women with self-reported stress and fatigue. Methods: Two-arm, parallel-group, 12-week, randomized, double-blind, placebo-controlled trial on overweight or mildly obese men and women aged 40–75 years, supplementing with 200 mg of an ashwagandha root extract (Witholytin®) twice daily. Results/Outcomes: Supplementation with ashwagandha was associated with a significant reduction in stress levels based on the Perceived Stress Scale (primary outcome); however, the improvements were not significantly different to the placebo group ( p = 0.867). Based on the Chalder Fatigue Scale, there was a statistically significant reduction in fatigue symptoms in the ashwagandha group compared to the placebo group ( p = 0.016), and participants taking ashwagandha also experienced a significant increase in heart rate variability ( p = 0.003). However, there were no significant between-group differences in other self-report outcome measures. In the men taking ashwagandha, there was a significant increase in the blood concentrations of free testosterone ( p = 0.048) and luteinizing hormone ( p = 0.002) compared to the placebo group. Conclusions/Interpretation: The results of this study suggest that in overweight middle-to-older age adults experiencing high stress and fatigue, compared to the placebo, ashwagandha did not have a significantly greater impact on perceived stress levels. However, based on secondary outcome measures, it may have anti-fatigue effects. This may be via its impact on the autonomic nervous system. However, further research is required to expand on these current findings.
Value of the neutrophil-to-lymphocyte ratio in chronic obstructive pulmonary disease complicated with pulmonary hypertension
Authors: Jiang Tingting , Wang Qi , Zhang Zhipeng , Qi Jun , Yang Ziyun , Jiang Qinghe , Wei Jing , Cao Dongming , Yuan Lindong 
Published: September 2023

Objective To investigate the relationship between the neutrophil-to-lymphocyte ratio and chronic obstructive pulmonary disease complicated with pulmonary hypertension (COPD + PH). Methods We retrospectively analyzed clinical data from 242 COPD patients at our hospital from July 2018 to July 2019. Patients underwent examinations including blood analysis, C-reactive protein, N-terminal brain natriuretic peptide (BNP), pulmonary function, and cardiac color ultrasound. Results Patients were divided into the COPD and COPD + PH groups using pulmonary arterial pressure (<50 and ≥50 mmHg, respectively). Compared with the COPD group, the COPD + PH group had greater pulmonary arterial pressure, smoking history, neutrophil-to-lymphocyte ratio (NLR), C-reactive protein, BNP, Chronic Obstructive Pulmonary Disease Assessment Test score, and right atrium and ventricular diameters, but smaller body mass index, forced vital capacity, lymphocyte count, and left ventricular diameter. BNP and NLR had positive effects on PH; forced vital capacity had a negative impact. Moreover, BNP (area under the curve [AUC] = 0.748, sensitivity = 0.692, specificity = 0.701) and NLR (AUC = 0.679, sensitivity = 0.831, specificity = 0.452) had predictive value for PH, and both were positively correlated with PH. Conclusions NLR is associated with COPD + PH, and may be useful for its diagnosis.