bluuebunny/crossref_metadata_2025_split huggingface dataset:
Collagen-nanoclay hydrogels for stiffness enhancement of the extracellular matrix: the effect on spheroid growth
Authors: Alamán Pilar 
Published: July 2023

The extracellular matrix (ECM) is crucial for regulating cellular functions and maintaining tissue integrity. Alterations in ECM stiffness are associated with various pathological conditions, including cancer and cardiovascular disease. Therefore, being able to tailor and customize ECM stiffness could revolutionize personalized research and therapies in tissue engineering. Clay nanomaterials are an emerging class of biomaterials with unique properties that make them promising candidates for biomedical applications.
In this study, we investigated the potential of laponite nanoclays (LapNC) to enhance the mechanical properties of collagen hydrogels without increasing the collagen amount. Collagen hydrogels of different concentrations (2.5, 4, and 6 mg/ml) were supplemented with LapNC, and the resulting hydrogels were thoroughly characterized using rheology, scanning electron microscopy (SEM) and other assays to quantify additional physical parameters, such as the permeability and swelling potential. In this study, we investigated the potential application of the customized hydrogels as 3D cancer culture systems for tumor spheroid growth. To this end, we quantified the spheroid area over time by culturing three cancer cell lines in the supplemented and non-supplemented matrices. Moreover, we assessed the migration capacity of the spheroids with respect to the initial cluster formation.
Our results confirmed that LapNC solution could be successfully incorporated into the culture media without clay aggregation. The supplemented hydrogels exhibited enhanced mechanical properties without compromising cellular viability or causing collagen collapse. Regardless of the collagen concentration, LapNC-supplemented hydrogels showed higher storage moduli and lower permeability than control hydrogels, which was qualitatively corroborated by SEM visualization of the porosity. Furthermore, the addition of LapNC resulted in the formation of larger spheroids at every collagen concentration. These findings have significant implications for tissue engineering applications, particularly in cancer spheroid analysis.
The successful incorporation of LapNC into collagen hydrogels as nanofillers to modify the rheological and structural properties highlights their potential for tissue engineering applications. Our results demonstrate that the mechanical properties of collagen hydrogels can be enhanced by the addition of LapNC without increasing collagen density. This may provide a powerful method for personalized research and therapies in multiple fields of tissue engineering. In particular, our study suggests that LapNC-supplemented hydrogels can serve as 3D cancer culture systems for stiffness-dependent tumor spheroid growth, opening up new avenues for cancer research and therapy.
Obtención experimental y análisis del subenfriamiento en la cinética de congelación del nopal (Opuntia spp)
Authors: Román-Aguilar R. , De Santiago-Herrera J. , Delgadillo-Ávila W.M. , Aparicio-Burgos J.E. , Valle-Hernández J. 
Published: July 2023

En el presente trabajo de investigación se muestra la obtención de forma experimental de la sección correspondiente al subenfriamiento en la cinética de congelación del nopal (Opuntia spp) y se desarrolla un análisis del fenómeno. Para su desarrollo se utilizaron sensores de temperatura tipo PT100 y termistores adaptados a un adquisitor de datos marca Keysinght modelo 34972A, previa calibración de los sensores con un patrón con trazabilidad al NIST en el rango de temperaturas de -22 a 40°C. Se utilizó nopal (Opuntia spp) en muestras de 3 cm x 3 cm y se realizaron 3 pruebas con 3 muestras cada una, colocando un sensor de temperatura al centro. Las muestras se enfriaron a 4 °C y después se introdujeron a un congelador a -20°C. Los resultados muestran que el nopal tiene un punto inicial de congelación de alrededor de -0.5 a -1.2°C y coinciden con los reportados por otros autores de forma analítica. Los resultados del presente estudio pueden utilizarse en el desarrollo de estrategias para evitar problemas en la formación de cristales de hielo en el nopal, de gran importancia para la manipulación del producto durante su conservación a bajas temperaturas.
Korelasi Hambatan Jenis dan Hambatan Konus untuk Identifikasi Zona Lemah Di Desa Sekotong Barat, Kecamatan Sekotong, Kabupaten Lombok Barat
Authors: Minardi Suhayat , Yudiana Rima , Alaydrus Alfina Taurida 
Published: July 2023

Ancaman kerusakan bangunan dan infrasruktur lainnya disebabkan oleh adanya zona lemah di bawah permukaan yang dapat menyebabkan bencana alam, seperti likuifaksi, khususnya di pesisir pantai, yang dicirikan memiliki muka air tanah dangkal, tingkat kepadatan lapisan tanah sangat lepas dan geologi daerah terdiri dari batu pasir dan endapan aluvium. Penelitian ini bertujuan untuk menentukan nilai hambatan jenis (resistivitas) dan hambatan konus dari zona lemah di Desa Sekotong Barat, Kecamatan Sekotong Kabupaten Lombok Barat dan bagaimana hubungan empiris nilai resistivitas dengan hambatan konus. Penelitian ini dilakukan menggunakan metode geolistrik konfigurasi Wenner dengan jumlah 6 lintasan dan panjang setiap lintasan 200 meter dan juga menggunakan uji sondir pada 3 titik. Berdasarkan hasil interpretasi data diperoleh litologi batuan di daerah penelitian terdiri dari lapisan pasir jenuh air, lempung lanauan, lempung pasiran dan pasir padat. Hasil inversi data geolistrik menunjukkan keberadaan zona lemah membentang pada seluruh daerah penelitian kecuali pada lintasan 3 dan lintasan 4 yang ditafsirkan tidak berbahaya bagi bangunan diatasnya karena tersusun oleh zona kuat. Diperoleh zona lemah dengan nilai resistivitas kurang dari 10 yang diidentifikasi sebagai lapisan pasir jenuh air dan lempung lanauan dan dibuktikan pula dengan hasil uji sondir memiliki nilai hambatan konus kurang dari 20 kg/cm2. Resistivitas dan hambatan konus berbanding lurus dan hubungan empiris yang dihasilkan berupa grafik polinomial orde tiga dengan koefisien determinasi.0,804
Pengaruh Model Pembelajaran Inkuiri Terbimbing dengan Metode Eksperimen terhadap Hasil Belajar Fisika Peserta Didik SMA
Authors: Zuhra Nisrina , Wahyudi Wahyudi , Harjono Ahmad , Zuhdi Muhammad 
Published: July 2023

This research aimed to determine the effect of guided inquiry learning model with the experimental method on physics learning outcomes of SMA students. This is quasi-experimental research with nonequivalent control group design. The population is all students grade XI MIPA in SMAN 1 Jonggat of academic year 2019/2020 with the sample is students class XI MIPA 4 and class XI MIPA 5 one wich is selected by purposive sampling which is the students class XI MIPA 4 as the experimental group and students class XI MIPA 5 as the control group. The experimental group giving treament with guided-inquiry learning model with the experimental method and control group giving treatment conventional learning. The measured learning otcomes data are the cognitive learning outcomes data. The learning outcomes data are measured in three conditions which is pretest in the form of multiple choice questions, during the learning process with use the LKPD, and posttest in the form of multiple chioice questions as much as 20 items that have been tested for validity. The hypotheses of research were tested using t-test polled variance with 5% significance level. The hypotheses tested result are > that is (4,00 > 2,00) so was rejected and was accepted. The result of hypotheses testing can be concluded there is an influence of guided-inquiry learning model with the experimental method on physics learning outcomes of SMA students. Keywords: Guided-inquiry learning model, experimental methods, learning outcome.
PENGARUH KUALITAS PRODUK DAN CUSTOMER INTIMACY TERHADAP LOYALITAS PELANGGAN ( KOPI TIME.IND ) DI KOTA PRAYA LOMBOK TENGAH
Authors: Aulia Lalu Nizwan , Saufi Akhmad , Ilhamudin Muhammad 
Published: July 2023

ABSTRACT
Product Quality and Customer Intimacy on Customer Loyalty KopiTime.Ind in Praya City, Central Lombok. All of the people in this study were KopiTime. Ind customers in Praya City, while 115 KopiTime were included in the study's sample. Utilizing a method called "purposive sampling," ind customers. Associative research is the term for this kind of study. The validity, reliability, classical assumption, path analysis, significance tests (t tests), coefficient of determination tests (R2), and sobel tests are performed using SPSS 26.0 for Windows in this study's data processing. Product quality has an effect on consumer loyalty, while customer intimacy has an effect on consumer loyalty, according to the analysis's findings product and services at the KopiTime.Ind shop.
ANALISIS PREFERENSI WISATAWAN TERHADAP HOMESTAY DI DESA WISATA TETEBATU KABUPATEN LOMBOK TIMUR
Authors: Sasmitha Alnisa Rizky , Rinuastuti Baiq Handayani , Permadi Lalu Adi 
Published: July 2023

ABSTRAK
Tujuan dari penelitian ini adalah untuk mengetahui seperti apa pengunjung homestay di Tetebatu. Pertama-tama, ada masalah tingkat persaingan yang ketat yang disebabkan oleh menjamurnya berbagai jenis homestay. Akibatnya, manajemen homestay seringkali kesulitan menentukan layanan mana yang paling penting bagi tamu dengan menggunakan Metode Kano. Informasi dikumpulkan dengan menggunakan kuesioner Kano, yang mencakup bagian fungsional dan disfungsional. Penelitian ini menggunakan metode purposive sampling untuk mengumpulkan data dari 50 responden. Dengan menggunakan Metode Kano, kita tahu bahwa homestay adalah salah satu pilihan utama wisatawan, menempatkannya dalam kategori Must-be (M). Kategori ini berarti berbagai atribut kualitas homestay di desa wisata Tetebatu harus dipenuhi.

Kata Kunci: Preferensi , Homesaty , Metode Kano

ABSTRACT
The purpose of this research is to learn what kind of homestays visitors to Tetebatu like. To begin, there is the problem of the intense degree of competition brought on by the proliferation of different kinds of homestays; as a result, homestay management often has trouble determining which services are most important to guests. The Kano Method is utilized. Information was gathered with the use of a Kano questionnaire, which included both a functional and a dysfunctional section. This study used a purposive sampling method to collect data from 50 participants. Using the Kano technique, we know that homestays are among the tourists' top choices, placing them in the Must-have (M) category. In order to qualify for this group, all of the Wista Tetebatu homestay's numerous quality qualities must be satisfied.

Keywords: preference, Homesaty, Metode Kano
МІСЦЕ ФАЛЬШИВИХ ДЕНАРІЇВ У ГОСПОДАРСТВІ НАСЕЛЕННЯ СЕРЕДНЬОГО ПОДНІСТРОВ‟Я ІІ–V СТ. Н. Е.
Authors: Zadorozhnyuk Andriy 
Published: July 2023

Мета статті полягає у трактуванні масових знахідок литих денаріїв на теренах Середнього Подністров’я, які були оприлюднені на різних інтернет форумах, внаслідок активного використання приладів металопошуку. Робиться спроба вивчення та з’ясування місця фальшивих денаріїв у господарстві варварських племен, акцентується увагу на проблемі економічної доцільності організації монетного виробництва на теренах згаданого регіону.
В період пізнього Риму на кордонах неосяжної імперії стали формуватися прикордонні контактні зони. Територія Середньої течії річки Дністер (сучасне Поділля) стала однією з таких зон, що означено значною кількістю зафіксованих пам’яток черняхівської культури. Регіон між Смотричем та іншими лівими притоками середньої течії Дністра і верхів’я Південного Бугу вважають вогнищем процесу формування черняхівської культури. Дослідження останніх років виявили нові пам’ятки пізньоримського часу і навіть місця ливарного виробництва монет та фібул того періоду. Зафіксовані численні знахідки фальшивих денаріїв місцевого виробництва, що ставить на порядок денний питання про доцільність їх виготовлення і місце цих монет у господарстві населення регіону.
Поширення фальшивої монети засвідчує масовий і добре організований грошовий обіг у місцевому середовищі. Жоден із монетних періодів не знає такої кількості фальшивих монет у грошовому обігу. До того ж, більшість таких денаріїв досить майстерно виконані і несуть сліди тривалого використання. Отже, значна кількість фальшивих монет – це вияв їх певного місця в господарському житті та певних потребах ринку.
Основні результати дослідження. Аналіз масових знахідок фальшивих денаріїїв, окремі з яких виявлені на місцях їх ливарного виробництва, слід розглядати в контексті поширення «римської моди» та масового використання фібул, каблучок і пряжок римського типу у місцевому середовищі. Вважаємо, що лімесні денарії доповнюють розуміння поліетнічності черняхівської культури, оскільки упродовж кількох століть вони забезпечували господарсько-економічні потреби внутрішньої торгівлі готської військової верхівки із землеробським виробником сільськогосподарської продукції.
A pathway to greater meaning in life and well-being for senior executives beset by anti-meaning
Authors: Kruger Juan-Mari , De Klerk Jeremias Jesaja 
Published: July 2023

IntroductionAlthough work is a significant source of meaning for most people, the role of senior executive generates different meaning and well-being complexities than those experienced or faced by general employees. This study explored how meaning and anti-meaning components affect senior executives’ experiences of meaning in life and well-being. The findings enabled devising a pathway to enhance senior executives’ net experiences of meaning in life and well-being.MethodsA cross-sectional, semi-structured interview study design was used to gather rich qualitative data. Eight participants from southern and eastern Africa, who had held the position of chief executive officer or managing director for at least five years, were interviewed.ResultsThe findings demonstrated that senior executives’ work roles provide a significant source of meaning. However, the roles are accompanied by unavoidable anti-meanings, which are likely to generate additional anti-meanings if not tempered sufficiently, thus reducing the net meaning experienced.DiscussionFrom the findings, a practical pathway was devised to assist top executives to deal with the bipolar relationship between meaning and anti-meaning. Consulting and counseling practitioners can utilize the pathway to guide, support, and counsel senior executives towards improved meaning, temper anti-meaning and improve well-being.
INDEKS MASSA TUBUH BERHUBUNGAN DENGAN KUALITAS TIDUR PADA MAHASISWA KEPERAWATAN DI UNIVERSITAS INDONESIA MAJU
Authors: Paramitha Riana , Ainul Shifa Nurul , Afrina Rina 
Published: July 2023

Pendahuluan : Tidur merupakan suatu kebutuhan dasar pada manusia. Kurang tidur dapat menyebabkan berbagai masalah kesehatan. kualitas tidur yang buruk dapat disebabkan oleh faktor apa pun, salah satunya adalah IMT. Tujuan : Penelitian ini bertujuan untuk mengidentifikasi hubungan antara indeks massa tubuh dan kualitas tidur pada mahasiswa keperawatan. Metode : Penelitian ini merupakan kuantitatif dengan desain cross-sectional. Responden dalam penelitian ini adalah mahasiswa keperawatan semester 3 dengan indeks massa tubuh underweight dan overweight dengan teknik pengambilan sampel Total Sampling sebanyak 38 orang. Pengumpulan data dilakukan dengan pengisian kuesioner PSQI untuk mengukur kualitas tidur dan lembar observasi untuk mengukur IMT. Pengolahan data dengan program komputer SPSS menggunakan uji chi square.
Hasil : Mayoritas dari responden dalam penelitian ini berusia 19-20 tahun (89,5%) dengan mayoritas jenis kelamin perempuan (84,2%). Lebih dari separuh responden memiliki indeks massa tubuh overweight (63,2%) dan sebagian besar mengalami kualitas tidur buruk (55,3%). Hasil analisa uji chi square menunjukkan nilai Pvalue = 0,004 yang artinya terdapat hubungan antara indeks massa tubuh dengan kualitas tidur. Kesimpulan : Ada hubungan indeks masa tubuh dengan kualitas tidur pada mahasiswa keperawatan di Universitas Indonesia Maju
Rancang Bangun Kontrol Pengolahan Gula Aren Dengan Programmable Logic Controller
Authors: Sawidin Sukandar Kandar , Putung Yoice R. , Waroh Anthoinete P.Y. , Marsela Tracy 
Published: July 2023

Gula aren diperoleh dari nira hasil sadapan pohon aren dan merupakan salah satu bahan baku dari pembuatan makanan maupun minuman. Pembuatan gula aren yang ada di Desa Tanggari Minahasa Utara Sulawesi Utara menggunakan bahan bakuair nira (saguer), akan tetapi pada proses pembuatan gula aren masih tradisional dengan menggunakan sepenuhnya tenaga manusia. Penelitian ini bertujuan untuk membuat prototype alat pengolah gula aren dengan menggunakan kontrol Programable Logic Controler (PLC) dan monitoring Human Machine Interface (HMI), dilengkapi dengan sensor thermostat sebagai alat pengukur temperatur pada saat proses pemasakan air nira dengan gas LPG dan motor wiper sebagai penggerak alat pengaduk. Hasil pengujian yang dilakukan untuk air nira 3 liter dengan suhu ± 100 0C diperoleh gula aren 750 gram. Dengan menggunakan kontrol PLC dan monitoring HMI pada alat pengolah gula aren ini diharapkan dapat meringankan tenaga pekerja dan mempercepat proses pengadukan gula aren sampai mengental sehingga pada akhirnya dapat meningkatkan efisiensi produksi.Palm sugar is obtained from the sap of palm tree tapping and is one of the raw materials for making food and drinks. The manufacture of palm sugar in the village of TanggariMinahasa Utara, North Sulawesi, uses sap (saguer) as the raw material, but the process of making palm sugar is still traditional, using full human power. This study aims to make a prototype of a palm sugar processing tool using Programable Logic Controler (PLC) control and Human Machine Interface (HMI) monitoring, equipped with a thermostat sensor as a temperature measuring device during the process of cooking sap water with LPG gas and a wiper motor as a driving force. mixer.From the results of tests carried out for 3 liters of sap water with a temperature of ± 100 0C, 750 grams of palm sugar was obtained.Using PLC control and HMI monitoring on the palm sugar processing equipment is expected to relieve labor and speed up the process of stirring the palm sugar until it thickens so that in the end it can increase production efficiency.
Task-Based Learning Enhancing 21st-Century Learning Outcomes
Authors: LANSARI Wassila Chahrazede Chahineze , HADDAM BOUABDALLAH Faiza 
Published: July 2023

Abstract
The present work aims at presenting a practical and effective way of developing communicative skills within English Foreign Language (EFL) classrooms by making EFL learners move from abstract learning to real context through Task-Based Learning (TBL). This approach uses tasks that include problem-solving situations and games that reflect real-life situations. It makes learners acquire the language in context and become less reliant on their teacher, who moves from the role of assistant and controller of the teaching/learning process to a guide and feedback provider. Though many teachers are more familiar with the traditional Present, Practice, Produce (PPP) approach, there is a new concept that should be introduced in EFL classrooms for broad exposure to the language and to minimise language difficulties.
Résumé
Ce travail vise à présenter une façon pratique et efficace de développer les compétences communicatives dans les salles de classe d'anglais comme étant langue étrangère (ALE) plutôt que se concentrer uniquement sur l’assimilation de connaissance théorique en encouragent les apprenants à s’engager activement dans des situations qui reflètent la vie réelle à travers l'apprentissage basé sur la pratique. Cette pédagogie utilise des compétences pratiques qui permet aux apprenants d'acquérir la langue dans son contexte et de développer leur compétence linguistique afin de devenir moins dépendants de leur enseignant, qui passe du rôle d'assistant et de contrôleur du processus d'enseignement/apprentissage à celui de guide et de fournisseur de rétroaction. Bien que de nombreux enseignants soient plus familiers avec l'approche traditionnelle Présentation, Pratique, Production (PPP), l'apprentissage basé sur les tâches permet aux apprenants de mettre en pratique leurs connaissances et leurs compétences de manière significative et une exposition plus large à la langue qui minimise les difficultés linguistiques.
KẾT QUẢ MỔ LẤY THAI CON SO TẠI BỆNH VIỆN ĐA KHOA TỈNH HÀ TĨNH
Authors: Nguyễn Cơ Thạch , Nguyễn Tuấn Minh , Đỗ Tuấn Đạt , Đặng Thị Minh Nguyệt 
Published: July 2023

Mục tiêu: Mô tả kết quả mổ lấy thai ở thai phụ con so tại Bệnh viện Đa khoa tỉnh Hà Tĩnh. Tiêu chuẩn chọn: Thai phụ được mổ lấy thai con so tại bệnh viện Đa khoa tỉnh Hà Tĩnh từ 01/01/2021 đến 30/6/2021, thai sống, tuổi thai > 28 tuần. Phương pháp nghiên cứu: mô tả. Kết quả: Mổ chủ động chiếm 32,5%, Nhóm trẻ sơ sinh có trọng lượng 3000 – 3500gr chiếm tỷ lệ 54.9%, nhóm trẻ nhẹ cân < 2500gr chiếm tỷ lệ thấp nhất 7%. Có 01 trường hợp trẻ sơ sinh ngạt nhẹ chiếm tỷ lệ 0,3%. Phương pháp vô cảm bằng gây tê tủy sống trong MLT là chủ yếu. Vào bụng bằng đường ngang trên xương vệ là chủ yếu, chiếm 99,5%. Rạch ngang đoạn dưới vào tử cung chiếm tỷ lệ lớn (99,5%). Có 02 trường hợp cắt tử cung bán phần chiếm tỷ lệ 0,5%. Kết luận: Con so mổ chủ động chiếm 32,5%, Vô cảm bằng gây tê tủy sống trong MLT là chủ yếu. Vào bụng bằng đường ngang trên xương vệ là chủ yếu, chiếm 99,5%. Rạch ngang đoạn dưới vào tử cung chiếm tỷ lệ lớn (99,5%),
Ta'tsir Istikhdam Wasila al Bitoqot al Wamdiyah 'Ala Tarqiyah Maharotu al Qiroah at Tollab
Authors: Nasution Raihan Fadillah , Rozaanah  
Published: July 2023

وسيلة التعليم هي كل ما يستخدم به الشخص لتبليغ المواد الدراسية فاندفع نظر الطلاب ورغبتهم وأفكارهم ومشاعرهم للبيئة التعليمية دافعا للحصول على الهدف المطلوب. الهدف من هذا البحث لمعرفة تأثير استخدام وسيلة البطاقات الومضية على مهارة القراءة في الصف الرابع بمدرسة عثمان بن عفان الابتدائية الإسلامية. والمنهج المستخدم هو المدخل الكمي بالنوع التجريبي مع تصميم البحث pre-experimental design النوع one group design pretest-posttes وطريقة تحليل البيانات هي الإحصائية. ونتيجة البحث وجود تأثير استخدام البطاقات الومضية على مهارة القراءة. ويستدله من نتيجة الاختبار-ت هي 7,562. وهذه النتيجة أكبر من نتيجة tt. وهي كما يلي: 2,72 > 7,562 <2,03. فالنتيجة t0 أكبر من نتيجة tt فالفرضية التبادلية مقبولة والفرضية العدمية مردودة.
Vulnerabilidade ao burnout em profissionais de saúde de um hospital público no norte de Moçambique
Authors: José Coutinho Maurício , Aliante Gildo , Abacar Mussa 
Published: July 2023

Esta pesquisa avaliou a frequência de burnout em profissionais de saúde. Aplicou-se o Spanish Burnout Inventory e questionário de dados sociodemográficos e laborais a 300 profissionais de um hospital público da região norte de Moçambique, majoritariamente do sexo feminino (n = 165; 55%), com idades entre 24 a 59 anos. A análise estatística de dados indicou que 95 (31,6%) participantes apresentaram baixos níveis na ilusão pelo trabalho, 232 (77,3%), 216 (72%) e 68 (22,6%) altos níveis em desgaste psíquico, indolência e culpa, respetivamente. Quanto ao perfil, 44 (14,6%) da amostra enquadraram-se no perfil 1 e seis (2,0%) no perfil 2. Verificou-se associação positiva entre as variáveis sexo, trabalho em regime de turnos e especialidade com as dimensões indolência e desgaste psíquico. A implantação de políticas de atenção à saúde do trabalhador pode contribuir na redução da vulnerabilidade ao burnout e na melhoria de qualidade de vida destes profissionais.