bluuebunny/crossref_metadata_2025_split huggingface dataset:
Musculoskeletal Disorders: Prevalence and Its factors Among Computer User Bankers of Dessie City, Northeast Ethiopia, 2022
Authors: Temesgen Tegegne , Sisay Tadesse , Teym Abraham , Yirdaw Getasew , Adane Balew , Tegegne Eniyew , Kumlachew Lake 
Published: May 2023

Abstract
Background
Musculoskeletal disorders are a major cause of occupational disability worldwide in computer users and impose a considerable burden on the individual, society, and industry in terms of absenteeism and cost of treatment. Studies on the risk of ergonomic exposure of computer users to the development of musculoskeletal disorder in banking industries are limited.
Objective
To determine the factors of musculoskeletal disorders and its prevalence among computer user bankers of Dessie city who regularly use computers at work.
Methodology
Institution based cross-sectional study was conducted among 269 bankers that use computer at work. They were selected from 21 bank branches by lottery method, and proportionally allocated. Then, the data was collected by self-administered questionnaire from each branch. After data clearance, data was entered into EPI software version 3.1 and exported to SPSS version 25.0. The data was analysed using descriptive statistical method and using bi-variable and multivariable logistic regression models. Variables with p-value < 0.05 with 95% CI was considered as statistically significant factor for developing musculoskeletal disorder.
Result
A total of 269 participants were included in this study with a response rate of 98.8%. The overall prevalence of musculoskeletal disorder was found to be 63.2% (95% CI: 56.8–68.8). factors like absence of display screen coverings (AOR = 1.96, 95% CI:1.01, 3.83), fixed type chair (AOR = 2.14, 95% CI: 1.02, 4.49), no enough working room (AOR = 2.59, 95% CI:1.47,4.58) and overtimes/unplanned work shifts (AOR = 1.85, 95% CI:1.06,3.25) were significantly associated factors to musculoskeletal disorder.
Conclusions
Based on our study, musculoskeletal disorder was a problem among computer user bankers, with an overall prevalence of 63.2%. We recommend that awareness creation through education and training on prevention and coping strategies for musculoskeletal disorders be made mandatory for bankers to reduce the occurrence of musculoskeletal disorders.
Factors Predicting Oral Health Behaviors of Adolescents in Shushtar
Authors: Marashi Seyedeh Zahra , Heidarnia Alireza , Kazemi Seyedeh Somayeh , Zarei Fatemeh 
Published: May 2023

Abstract
Background: Tooth decay and other oral health (periodontal) diseases have a high global prevalence and are considered an important economic burden. Oral and dental hygiene is so important for the adolescent age group that the World Health Organization has declared tooth decay as one of the most important health problems in the world. Therefore, this study aims to determine the predictors of oral health behaviors of teenagers in Shushtar.
Methods: The current research is a descriptive-analytical cross-sectional study that was conducted in Summer 2022 on 415 teenagers of the first secondary school in Shushtar. The data collection method was two standard questionnaires. The questionnaire included demographic information and questions related to measuring awareness, attitude, performance, and self-efficacy regarding the oral health behaviors of adolescents. The data was analyzed in spss22 statistical software and using descriptive statistics and ANOVA, T-test, Pearson correlation, and regression analysis.
Results: The average score of knowledge, attitude, self-efficacy in brushing teeth, self-efficacy in flossing, self-efficacy in going to the dentist, and adolescents' performance on oral health behaviors are respectively 5.72 ± 2.06,36.40±6.36, 25.40±7.49, 6.06±14.15, 5.59±15.80 and 14.01±4.02. There has been a significant correlation between knowledge, attitude, self-efficacy, and performance. Also, there was a significant relationship between awareness, attitude, self-efficacy, performance, and brushing frequency (P<0.05).
Conclusion: According to the results of this research, the lack of awareness, performance, self-efficacy, and good attitude of teenagers regarding oral health, and on the other hand, the importance of the adolescent age group and the formation of oral and dental health behaviors and its impact on Adulthood, increasing the knowledge of teenagers and consequently improving health behaviors through holding educational classes in schools is suggested.
Uplifts and hassles are related to worsening in chronic fatigue syndrome A prospective study
Authors: Friedberg Fred , Adamowicz Jenna L. , Bruckenthal Patricia , Milazzo Maria , Ramjan Sameera , Zhang Xiaoyue , Yang Jie 
Published: May 2023

AbstractBackground:Limitedpublished data suggests that absence of uplifts (minor pleasant events) is associated with clinical worsening in patients with chronic fatigue syndrome (CFS). The current study aimed to assess the relation of illness worsening to the trajectories of social and non-social uplifts and hassles in a six-month prospective study in CFS.Methods:Participants were primarily in their 40s, female, white, and ill for over a decade. All participants (N=128) met criteria for CFS. The interview-based global impression of change rating was used to classify individual outcomes as improved, unchanged, or worsened at six- month follow-up. Uplifts and hassles, both social and non-social, were assessed with the Combined Hassles and Uplifts Scale (CHUS). The CHUS was administered weekly in online diaries over six months. Linear mixed effect models were utilized to examine linear trends for hassles and uplifts.Results:No significant differences were found between the three global outcome groups for age, sex, or illness duration; however, work status was significantly lower for the non-improved groups (p<.001). Non-social hassles intensity showed an increasing slope for the worsened group (p=.03) and a decreasing slope (p=0.05) for the improved group. For the worsened group, a downward trend was found for frequency of non-social (p=0.01) uplifts.Conclusion:Individuals with worsening as compared to improving illness in CFS show significantly different six-month trajectories for weekly hassles and a deficit in uplifts. This may have clinical implications for behavioral intervention. Trial Registration: ClinicalTrials.gov ID: NCT02948556
Beginning of implementation of Nature-Based Solutions (NbS) in Serbia: Case study of the first implemented rain gardens within suburban community Kać
Authors: Greksa Amela , Blagojević Boško , Grabić Jasna 
Published: May 2023

Abstract
In recent years, the concept of Nature-based Solutions (NbS) is being accepted as an integrated approach that provides multiple ecosystem services. Serbia is among many European countries with a growing interest for the implementation of the NbS. This paper presents the results of assessment of two rain gardens (RGs) taken as case studies, implemented as some of the first examples of NbS. The research methodology is based on evaluation of the hydrologic effectiveness through continuous visual inspection during the period after RGs construction in the first year, second and third year after RGs establishment. Visual inspection involved observations of the basic functions of RGs i.e. flow reduction during storm events, presence of standing water or overflows, time of infiltration, vegetation health and establishment. Mentioned items were monitored in order to understand the performances and test the functionality of RGs due to their further implementation. Findings based on visual assessment showed that: a) both RGs infiltrate runoff during rain and snow events with no presence of standing water after 24 hours and b) rain gardens can reduce peak flows and total flow volume in a short period of time for rainfall depths that are connected with different return periods and flood frequency. The RGs also showed excellent plant growth rate and rapid plant establishment within environmental conditions in the RGs. This study highlights overall good adaptation of RGs under local soil and typical continental climate and contributes to limited research about performances of RGs as NbS in Serbian practice.
Spatiotemporal visualization of CO2 electrolysis
Authors: Berlinguette Curtis , Lu Xin , Zhou Chris , Delima Roxanna , Lees Eric , Soni Abhishek , Dvorak David J. , Ren Shaoxuan , Ji Tengxiao , Bahi Addie , Ko Frank 
Published: May 2023

Abstract
We report here an electrolysis optical coherence tomography (eOCT) platform to visualize the chemical reactions occurring in a CO2 electrolyzer. The eOCT platform was designed to capture three dimensional images and videos at high spatial (~1 µm) and temporal (<1 µs) resolutions. We captured 12 h of footage of an electrolyzer, containing a porous electrode separated by a membrane, converting a continuous feed of liquid KHCO3 to reduce CO2 into CO at applied current densities of 50-800 mA cm−2. This video resolved the nucleation and formation of CO2 in the cathode compartment upon reaction of HCO3– with H+ delivered through the membrane, the formation of CO at the cathode|electrolyte interface, and H2 throughout the cathode compartment. The video captured the strikingly dynamic movement of the cathode and membrane components during electrolysis, and linked CO production to regions of the electrolyzer in which CO2 were in direct contact with both the membrane and the catalyst layers. This visualization enabled us to correlate the decrease in CO production to a buildup of CO2, CO, and H2, and (bi)carbonate salts at the cathode layer. The statistical analysis of phase distribution images allowed us to understand the competition between main (CO2 reduction) and side (hydrogen evolution) reactions in both time and space domains. We also show how a pulsing current liberates these residual bubbles and (bi)carbonates to recover CO production. These results highlight the power of using an eOCT platform to temporally and spatially resolve CO2RR electrolysis.
Anthelmintic activity of European fern extracts against Haemonchus contortus
Authors: Pavičić Antonio , Zajíčková Markéta , Šadibolová Michaela , Svobodová Gabriela , Matoušková Petra , Szotáková Barbora , Langhansová Lenka , Maršík Petr , Skálová Lenka 
Published: May 2023

Abstract
Most drugs used in the treatment of helminthiasis in humans and animals have lost their efficacy due to the development of drug-resistance in helminths. Moreover, since anthelmintics, like many pharmaceuticals, are now recognized as hazardous contaminants of the environment, returning to medicinal plants and their products represents an environmentally friendly way to treat helminthiasis. The goal of the present study was to test the anthelminthic activity of methanol extracts of eight selected European ferns from the genera Dryopteris, Athyrium and Blechnum against the nematode Haemonchus contortus, a widespread parasite of small ruminants. Eggs and adults of H. contortus drug-susceptible strain ISE and drug-resistant strain WR were isolated from experimentally infected sheep. The efficacy of fern extracts was assayed using egg hatch test and adults viability test based on ATP-level measurement. Among the ferns tested, only Dryopteris aemula extract (0.2 mg/ml) inhibited eggs hatching by 25% in comparison to control. Athyrium distentifolium, Dryopteris aemula and Dryopteris cambrensis were effective against H. contortus adults. In concentration 0.1 mg/ml, A. distentifolium, D. aemula, D. cambrensis significantly decreased the viability of females from ISE and WR strains to 36.2%, 51.9%, 32.9% and to 35.3%, 27.0%, 23.6, respectively in comparison to untreated controls. None of the extracts exhibited toxicity in precise cut slices from ovine liver. Polyphenol’s analysis identified quercetin, kaempferol, luteolin, 3-hydroxybenzoic acid, caffeic acid, coumaric acid and protocatechuic acid as the major components of these anthelmintically active ferns.
Left Ventricular Remodeling Response to SGLT2 inhibitors in Heart Failure: An Updated Meta-analysis of Randomized Controlled Studies
Authors: Carluccio Erberto , Biagioli Paolo , Reboldi Gianpaolo , Mengoni Anna , Lauciello Rosanna , Zuchi Cinzia , D’Addario Sandra , Bardelli Giuliana , Ambrosio Giuseppe 
Published: May 2023

Abstract
Background:
Randomized controlled trials (RCTs) reported contrasting results about reverse left ventricular remodeling (LVR) after sodium-glucose co-transporter-2 inhibitors (SGLT2i) therapy in patients with heart failure (HF).
Methods and Results:
We performed a metanalysis of RCTs of SGLT2i administration in HF outpatients published until June 2022 searching four electronic databases. The protocol has been published in PROSPERO. Primary LVR outcome was change in absolute LV end-diastolic (LVEDV) and end-systolic volume (LVESV) from baseline to study endpoint. Secondary outcomes included changes in LVEDV and LVESV indexed to body surface area, LV Mass index (LVMi), LV ejection fraction (LVEF), and N-terminal pro-B-type natriuretic peptide (NTproBNP). Mean differences (MDs) with 95% CIs were pooled. A total of 9 RCTs (1385 patients) were analyzed. All of them reported data on LVEF. Six trials reported data on LVESV and LVEDV (n=951); LVMi was available in 640. SGLT2i treatment significantly reduced LVEDV [MD= -10.59 ml (-17.27; -3.91), P=0.0019], LVESV [MD= -8.80 ml (-16.91; -0.694), P=0.0334], and LVMI [MD= -5.34 gr/m2 (-9.76; -0.922), P=0.0178], while LVEF significantly increased [MD= +1.98% (0.67; 0.306), P=0.0031]. By subgroup analysis, the beneficial effects of SGLT2i on LVEF did not differ by imaging method used, time to follow-up re-evaluation, or HF phenotype. Reduction in LV volumes tended to be greater in HF with reduced EF (HFrEF) than in those with preserved EF (HFpEF), while the opposite was observed for LVMi.
Conclusions:
Treatment with SGLT2i significantly reversed cardiac volumes, improving LV systolic function and LV mass, particularly in HFrEF patients.
The Missing Voices in the Conscientious Objection Debate: UK Service Users’ Experiences of Conscientious Objection to Abortion.
Authors: Self Becky , Maxwell Clare , Fleming Valerie 
Published: May 2023

Abstract
Background The fourth section of the 1967 Abortion Act states that individuals (including health care practitioners) do not have to participate in an abortion if they have a conscientious objection. A conscientious objection is a refusal to participate in abortion on the grounds of conscience. This may be informed by religious, moral, philosophical, ethical, or personal beliefs. Currently, there is very little investigation into the impact of conscientious objection on service users in the UK. The perspectives of service users are imperative in understanding the real-world consequences and potential impact of conscientious objection and should be considered when creating policies and guidelines. This research provided a platform for women and those who can become pregnant to share their experiences and opinions at a time when these voices are largely excluded in the great tradition of western political philosophy and law-making processes.Method Five service users were interviewed using a narrative interview approach to uncover their abortion journeys and experiences of conscientious objection.Results Doctors are not always informing service users of their right to an abortion, giving service users enough information to access abortion (indirect referral), treating them non-judgmentally, and providing medically correct information. Service users did not experience burdens such as long waiting times and were still able to access legal abortion. However, service users did experience negative emotional effects, as they were often left feeling scared, angry, and hopeless when they were not referred and/or were mistreated.Conclusions Findings indicate that conscientious objection could work in practice. However, it is currently failing some individuals on an emotional level, as not all doctors are adhering to policy and guidelines. Conscientious objection in the UK needs to be addressed, to ensure service users receive fair, impartial, non-judgmental care.
Association between Alcohol and Urolithiasis: A Mendelian Randomization Study
Authors: Yang Shijian , Tan Wenyue , Wei Baian , Gu Chiming , Li Siyi , Wang Shusheng 
Published: May 2023

Abstract
Background The causal relationship between alcohol and urolithiasis remains uncertain, despite previous observational studies reporting an association between the two. To determine the causality, we conducted a two-sample Mendelian randomization (MR) analysis.Methods In this study, we aimed to investigate the causal relationship between alcohol and kidney stones using a two-sample MR approach. Two sets of genetic instruments were utilized in the analysis, both of which were derived from publicly available genetic summary data. The first set consisted of 73 single-nucleotide polymorphisms (SNPs) robustly linked to alcohol intake frequency (AIF) and the second set was comprised of 69 SNPs associated with alcohol consumption (AC). Our MR analysis was performed using several methods including the inverse-variance weighted (IVW) method, weighted median method, MR-Egger regression, MR Pleiotropy RESidual Sum and Outlier test.Results Our results from the MR analysis revealed a borderline significant association between AIF and the risk of urolithiasis. This was established through the use of the IVW method (OR(95%CI) = 1.29(1.02,1.65), p = 0.036) and the weighted median approach (OR(95%CI) = 1.44(1.10,1.89), p = 0.008). The MR-Egger model also yielded similar risk estimates (OR(95%CI) = 1.39(0.66,2.93), p = 0.386), although the relationship was not statistically significant. Sixty-eight SNPs were identified as having a substantial and independent link with AC. However, the IVW approach revealed no significant effect of AC on the risk of urolithiasis (OR(95%CI) = 0.74(0.48,1.14), p = 0.173).Conclusions The MR analysis suggested a potential causal association between alcohol intake frequency and the risk of urolithiasis, but not alcohol consumption.
A Rare Clinical Case of Celiac Trunk Anatomy in a Patient with Siewert III Cardioesophageal Junction Cancer
Authors: Khorobrykh Tatyana , Ivashov Ivan , Spartak Alexey , Reiter Victoriia , Grachalov Anton , Pronina Polina 
Published: May 2023

Abstract
Purpose: The normal anatomy of the celiac trunk (CT) is characterized by splitting into three branches in approximately 80% of cases. In other cases, multiple anatomical variations can be observed. The purpose of this study was to review the clinical case featuring an extremely rare location of common hepatic artery (CHA) and to emphasize the importance of being familiar with possible anatomical variations of the hepatic artery through preoperative imaging in preparation for oncological surgery.
Methods: We report a rare anatomical variation of replaced common hepatic artery, when it is located as VI type of Hiatt’s classification – CHA branching from abdominal aorta (AA). It was discovered during contrast-enhanced computed tomography and illustrated by 3D reconstruction of vascular architectonics of the celiac trunk.
Results: A 71-year-old patient presented with Siewert III cardioesophageal junction cancer with liver metastases (T2N2M1, stage IV). Preoperative contrast-enhanced computed tomography (CECT) showed that the CHA branched from the AA. The operation included the proximal resection of the stomach and abdominal esophagus, D2 lymph nodes dissection, peritumoral liver resection, and extramucosal pyloroplasty.
Conclusion: This case shows the importance of preoperative preparation using CECT to identify anatomical variations of the CHA, particularly for patients with locally advanced and metastatic cancer. This is due to the fact that the CHA is an important intraoperative landmark in the process of lymph nodes dissection, and awareness of its rare anatomical variation allowed us to shorten the operation time and reduce the risk of intra- and postoperative complications.
Hydrogeochemical characterization of groundwater quality, East of Mount Cameroon and West of the Penda Mboko River, suitability for drinking and irrigation use
Authors: Jude Ngai N , Wotany Engome Regina , Agyingi Christopher , Ghomsi Kemgang , Maffo Kankeu Gisele Aurore , Menti Agbor Nelson , Armel Zacharie Ekoa 
Published: May 2023

Abstract
The physicochemical properties and impacts on water quality were evaluated in volcanic and sedimentary aquifer systems for management and sustainable development. Fifty (50) water samples were collected from hand dug wells, boreholes springs and rivers. The physicochemical parameters (pH, EC, TDS, T, and Salinity) were measured in situ. The pH ranged from 6.22 to 6.68 with a mean of 6.49 signifying slightly acidic. Slightly mineralized water sources with TDS that ranged from 11 to 211 mg / l. The mean concentration of the major ions indicated Ca2+ >Mg2+ > Na+ > k+ and HCO3− >CL− >NO3− >SO42− The hydrochemical facies were Ca-Cl type (74%), Ca-HCO3 type (20%), and mixed Ca-Mg-Cl (6%). The Gibbs plots indicated 86% dominance of rock weathering influencing the chemistry of the water sources, 14% by precipitation and cation-exchange as indicated by positive CAI values. Twenty-nine (58%) samples were classified as excellent water quality (Rank I) according to the Drinking Water Quality Index (DWQI). At the same time, 13 (26%) samples had drinking water of good quality (rank II). In the research area, the distribution of groundwater physicochemical indicators and drinking water quality index (DWQI) was shown. According to the Wilcox diagram connecting sodium percentage with total concentration, all of the samples fell in the good to permissible for irrigation. Based on Residual Sodium Carbonate (RSC) and Soluble Sodium Percentage (SSP), the results indicated that the majority of the groundwater samples were suitable for irrigation.
Construction of five disulfidptosis-related lncRNA signature for predicting prognosis and immune activity in kidney renal clear cell carcinoma
Authors: Xu Kangjie , Li Dongling , Zhang Minglei , Zhou Hai , Hou Xuefeng , Jiang Jian , Zhang Zihang , Dai Hua , Sun Hang 
Published: May 2023

Abstract
Kidney renal clear cell carcinoma (KIRC) is a highly aggressive cancer. Disulfidptosis is a newly discovered mechanism of programmed cell death. However, the role of disulfidptosis-related lncRNAs (DRlncRNAs) in KIRC remains unknown. This study aimed to develop a prognostic model of DRlncRNAs and explore their prognostic value in KIRC. RNA-seq and relevant clinical data were obtained from The Cancer Genome Atlas (TCGA) database. Univariate Cox regression, lasso algorithm and multivariate Cox regression analysis identified DRlncRNAs and established a prognostic model. Multiple methods to assess the reliability of the model. In addition, Gene Set Enrichment Analysis (GSEA), immune infiltration analysis, somatic mutation analysis, and drug prediction were performed on the model. qRT-PCR has identified the intracellular expression of DRlncRNAs. We constructed a prognostic model with five DRlncRNAs and proved that the model was a good predictor of survival and prognosis of KIRC patients. GSEA indicated that DRlncRNAs were associated with apoptosis and immune-related pathways. Immune correlation analysis suggested that low-risk patients had better immunotherapeutic outcomes. Besides, somatic mutation analysis revealed that low-risk patients had a lower somatic mutation rate and TMB score and better prognostic. Drug prediction showed that axitinib, ibrutinib, osimertinib, and ruxolitinib were more effective in the low-risk patients; Crizotinib, lapatinib, linsitinib, and nilotinib were more effective in the high-risk patients. Finally, qRT-PCR confirmed the expression of DRlncRNAs in normal kidney cells and KIRC cell lines. In summary, we constructed a risk model and provided a new direction for diagnosing and treating KIRC.