bluuebunny/crossref_metadata_2025_split huggingface dataset:
Value-Added Products Derived from 15 Years of High-Quality Surface Solar Radiation Measurements at Xianghe, a Suburban Site in the North China Plain
Authors: Liu Mengqi , Fan Xuehua , Xia Xiang’ao , Zhang Jinqiang , Li Jun 
Published: February 2023

AbstractSurface solar radiation (SSR) is a key component of the energy budget of the Earth’s surface, and it varies at different spatial and temporal scales. Considerable knowledge of how and why SSR varies is crucial to a better understanding of climate change, which surely requires long-term measurements of high quality. The objective of this study is to introduce a value-added SSR dataset from Oct 2004 to Oct 2019 based on measurements taken at Xianghe, a suburban site in the North China Plain; two value-added products based on the 1-minute SSR measurements are developed. The first is clear sky detection by using a machine learning model. The second is cloud fraction estimation derived from an effective semi-empirical method. A “brightening” of global horizontal irradiance (GHI) was revealed and found to occur under both clear and cloudy conditions. This could likely be attributed to a reduction in aerosol loading and cloud fraction. This dataset could not only improve our knowledge of the variability and trend of SSR in the North China Plain, but also be beneficial for solar energy assessment and forecasting.
Analysis of adverse events related to extracorporeal membrane oxygenation from a nationwide database of patient-safety accidents in Japan
Authors: Hadano Hiroki , Kamio Tadashi , Fukaguchi Kiyomitsu , Sato Mizuki , Tsunano Yumiko , Koyama Hiroshi 
Published: February 2023

AbstractAlthough adverse events related to extracorporeal membrane oxygenation have been reported, epidemiological data on life-threatening events are insufficient to study the causes of such adverse events. Data from the Japan Council for Quality Health Care database were retrospectively analyzed. The adverse events extracted from this national database included events associated with extracorporeal membrane oxygenation reported between January 2010 and December 2021. We identified 178 adverse events related to extracorporeal membrane oxygenation. At least 41 (23%) and 47 (26%) accidents resulted in death and residual disability, respectively. The most common adverse events were cannula malposition (28%), decannulation (19%), and bleeding (15%). Among patients with cannula malposition, 38% did not undergo fluoroscopy-guided or ultrasound-guided cannulation, 54% required surgical treatment, and 18% required trans-arterial embolization. In this epidemiological study in Japan, 23% of the adverse events related to extracorporeal membrane oxygenation had fatal outcomes. Our findings suggest that a training system for cannulation techniques may be needed, and hospitals offering extracorporeal membrane oxygenation should perform emergency surgeries.
Physiological and genomic insights into abiotic stress of halophilic archaeon Natrinema altunense 4.1R isolated from a saline ecosystem of Tunisian desert
Authors: Najjari Afef , Boussetta Ayoub , Youssef Noha , Linares-Pastén Javier A. , Mahjoubi Mouna , Belloum Rahma , Sghaier Haitham , Cherif Ameur , Ouzari Hadda Imene 
Published: February 2023

AbstractHalophilic archaea are polyextremophiles with the ability to withstand fluctuations in salinity, high levels of ultraviolet radiation, and oxidative stress, allowing them to survive in a wide range of environments and making them an excellent model for astrobiological research. Natrinema altunense 4.1R is a halophilic archaeon isolated from the endorheic saline lake systems, Sebkhas, located in arid and semi-arid regions of Tunisia. It is an ecosystem characterized by periodic flooding from subsurface groundwater and fluctuating salinities. Here, we assess the physiological responses and genomic characterization of N. altunense 4.1R to UV-C radiation, as well as osmotic and oxidative stresses. Results showed that the 4.1R strain is able to survive up to 36% of salinity, up to 180 J/m2 to UV-C radiation, and at 50 mM of H2O2, a resistance profile similar to Halobacterium salinarum, a strain often used as UV-C resistant model. In order to understand the genetic determinants of N. altunense 4.1R survival strategy, we sequenced and analyzed its genome. Results showed multiple gene copies of osmotic stress, oxidative stress, and DNA repair response mechanisms supporting its survivability at extreme salinities and radiations. Indeed, the 3D molecular structures of seven proteins related to responses to UV-C radiation (excinucleases UvrA, UvrB, and UvrC, and photolyase), saline stress (trehalose-6-phosphate synthase OtsA and trehalose-phosphatase OtsB), and oxidative stress (superoxide dismutase SOD) were constructed by homology modeling. This study extends the abiotic stress range for the species N. altunense and adds to the repertoire of UV and oxidative stress resistance genes generally known from haloarchaeon.
Real-world treatment response in Japanese patients with cancer using unstructured data from electronic health records
Authors: Araki Kenji , Matsumoto Nobuhiro , Togo Kanae , Yonemoto Naohiro , Ohki Emiko , Xu Linghua , Hasegawa Yoshiyuki , Inoue Hirofumi , Yamashita Sakiko , Miyazaki Taiga 
Published: February 2023

Abstract
Purpose
We generated methods for evaluating clinical outcomes including treatment response in oncology using the unstructured data from electronic health records (EHR) in Japanese language.

Methods
This retrospective analysis used medical record database and administrative data of University of Miyazaki Hospital in Japan of patients with lung/breast cancer. Treatment response (objective response [OR], stable disease [SD] or progressive disease [PD]) was adjudicated by two evaluators using clinicians’ progress notes, radiology reports and pathological reports of 15 patients with lung cancer (training data set). For assessing key terms to describe treatment response, natural language processing (NLP) rules were created from the texts identified by the evaluators and broken down by morphological analysis. The NLP rules were applied for assessing data of other 70 lung cancer and 30 breast cancer patients, who were not adjudicated, to examine if any difference in using key terms exist between these patients.

Results
A total of 2,039 records in progress notes, 131 in radiology reports and 60 in pathological reports of 15 patients, were adjudicated. Progress notes were the most common primary source data for treatment assessment (60.7%), wherein, the most common key terms with high sensitivity and specificity to describe OR were “reduction/shrink”, for SD were “(no) remarkable change/(no) aggravation)” and for PD were “(limited) effect” and “enlargement/grow”. These key terms were also found in other larger cohorts of 70 patients with lung cancer and 30 patients with breast cancer.

Conclusion
This study demonstrated that assessing response to anticancer therapy using Japanese EHRs is feasible by interpreting progress notes, radiology reports and Japanese key terms using NLP.
Vascular dysregulation in glaucoma: retinal vasoconstriction and normal neurovascular coupling in altitudinal visual field defects
Authors: Zhou Wanshu , Sabel Bernhard A. 
Published: February 2023

Abstract

Purpose
Vision loss in glaucoma is not only associated with elevated intraocular pressure and neurodegeneration, but vascular dysregulation (VD) is a major factor. To optimize therapy, an improved understanding of concepts of predictive, preventive, and personalized medicine (3PM) is needed which is based on a more detailed understanding of VD pathology. Specifically, to learn if the root cause of glaucomatous vision loss is of neuronal (degeneration) or vascular origin, we now studied neurovascular coupling (NVC) and vessel morphology and their relationship to vision loss in glaucoma.

Methods
In patients with primary open angle glaucoma (POAG) (n = 30) and healthy controls (n = 22), NVC was studied using dynamic vessel analyzer to quantify retinal vessel diameter before, during, and after flicker light stimulation to evaluate the dilation response following neuronal activation. Vessel features and dilation were then related to branch level and visual field impairment.

Results
Retinal arterial and venous vessels had significantly smaller diameters in patients with POAG in comparison to controls. However, both arterial and venous dilation reached normal values during neuronal activation despite their smaller diameters. This was largely independent of visual field depth and varied among patients.

Conclusions
Because dilation/constriction is normal, VD in POAG can be explained by chronic vasoconstriction which limits energy supply to retinal (and brain) neurons with subsequent hypo-metabolism (“silent” neurons) or neuronal cell death. We propose that the root cause of POAG is primarily of vascular and not neuronal origin. This understanding can help to better personalize POAG therapy of not only targeting eye pressure but also vasoconstriction to prevent low vision, slowing its progression and supporting recovery and restoration.

Trial registration
ClinicalTrials.gov, # NCT04037384 on July 3, 2019.
Italian guidance on Dementia Day Care Centres: A position paper
Authors: Mossello Enrico , Baccini Marco , Caramelli Francesca , Biagini Carlo Adriano , Cester Alberto , De Vreese Luc Pieter , Darvo Gianluca , Vampini Claudio , Gotti Mabel , Fabbo Andrea , Marengoni Alessandra , Cavallini Maria Chiara , Gori Guido , Chattat Rabih , Marini Monica , Ceron Davide , Lanzoni Alessandro , Pizziolo Paolo , Mati Andrea , Zilli Iole , Cantini Claudia , Caleri Veronica , Tonon Elisabetta , Simoni David , Mecocci Patrizia , Ungar Andrea , Masotti Giulio ,   the Italian Group on Dementia Day Care Centres
Published: February 2023

AbstractDementia Day Care Centres (DDCCs) are defined as services providing care and rehabilitation to people with dementia associated with behavioural and psychological symptoms (BPSD) in a semi-residential setting. According to available evidence, DDCCs may decrease BPSD, depressive symptoms and caregiver burden. The present position paper reports a consensus of Italian experts of different disciplines regarding DDCCs and includes recommendations about architectural features, requirements of personnel, psychosocial interventions, management of psychoactive drug treatment, prevention and care of geriatric syndromes, and support to family caregivers. DDCCs architectural features should follow specific criteria and address specific needs of people with dementia, supporting independence, safety, and comfort. Staffing should be adequate in size and competence and should be able to implement psychosocial interventions, especially focused on BPSD. Individualized care plan should include prevention and treatment of geriatric syndromes, a targeted vaccination plan for infectious diseases including COVID-19, and adjustment of psychotropic drug treatment, all in cooperation with the general practitioner. Informal caregivers should be involved in the focus of intervention, with the aim of reducing assistance burden and promoting the adaptation to the ever-changing relationship with the patient.
Bayes Factors for Mixed Models: a Discussion
Authors: van Doorn Johnny , Haaf Julia M. , Stefan Angelika M. , Wagenmakers Eric-Jan , Cox Gregory Edward , Davis-Stober Clintin P. , Heathcote Andrew , Heck Daniel W. , Kalish Michael , Kellen David , Matzke Dora , Morey Richard D. , Nicenboim Bruno , van Ravenzwaaij Don , Rouder Jeffrey N. , Schad Daniel J. , Shiffrin Richard M. , Singmann Henrik , Vasishth Shravan , Veríssimo João , Bockting Florence , Chandramouli Suyog , Dunn John C. , Gronau Quentin F. , Linde Maximilian , McMullin Sara D. , Navarro Danielle , Schnuerch Martin , Yadav Himanshu , Aust Frederik 
Published: February 2023

Abstractvan Doorn et al. (2021) outlined various questions that arise when conducting Bayesian model comparison for mixed effects models. Seven response articles offered their own perspective on the preferred setup for mixed model comparison, on the most appropriate specification of prior distributions, and on the desirability of default recommendations. This article presents a round-table discussion that aims to clarify outstanding issues, explore common ground, and outline practical considerations for any researcher wishing to conduct a Bayesian mixed effects model comparison.
Astaxanthin- Enriched Fraction from the Microalga Haematococcus pluvialis Mitigates Kidney Injury via Modulation of Nrf2/Keap1 and MAPK/ERK Pathways in Rats
Authors: El-Baz Farouk K. , Ali Sami I. , Salama Abeer , Elgohary Rania 
Published: February 2023

AbstractAcute kidney injury is a complication of using gentamicin in high doses and is associated with severe morbidity and mortality. Astaxanthin, the red xanthophyll carotenoid pigment, has an antioxidant power higher than 100 times that of vitamin E and 10 times more than that of β-carotene, making it one of the strongest bioactive carotenoids. Haematococcus pluvialis, Haematococcaceae, microalga produces high amounts of astaxanthin in the form of astaxanthin esters besides adequate amounts of free astaxanthin. We attempted to explore the potential therapeutic effects of astaxanthin- and astaxanthin ester–enriched fractions from H. pluvialis against acute kidney injury induced by gentamicin and their mechanisms of action in rats. Adult male Wister albino rats were injected with gentamicin (100 mg/kg, i.p.) for seven consecutive days to induce acute kidney injury, and these rats were treated daily with astaxanthin ester–enriched fractions (30 mg/kg; p.o.) for 14 days. LC/ESI–MS analysis revealed the presence of different isomers of free astaxanthin, astaxanthin monoesters, and astaxanthin diesters in the astaxanthin- and astaxanthin ester–enriched fractions. Astaxanthin and its esters ameliorated kidney dysfunction, modulated nuclear factor erythroid 2 related factor 2/Kelch-like erythroid associated protein 1/hypoxia-inducible factor-alpha, and suppressed mitogen-activated protein kinases/extracellular signal-regulated kinases/renin-angiotensin system expression. Astaxanthin and its ester improved early acute kidney injury via modulation of the Nrf2/Keap1 antioxidant defense pathway and MAPK/ERK signaling cascade.
Graphical Abstract
A Comparative Study on Language Teacher Immunity: Samples from Qatar and Turkey
Authors: Canbay Mehmet Orkun , Sönmez Görsev 
Published: February 2023

AbstractThis study investigated the language teacher immunity with samples from two educational settings. Using quantitative ways of data collection, the research precisely focused on whether language teacher immunity manifests itself in different ways considering the place of work and years of experience with the language teachers in Qatar and Turkey (n = 130). The findings revealed that language teacher immunity shows significant differences according to the place of work and years of experience with few constructs.
Predictors of successful diversion of cats and dogs away from animal shelter intake: Analysis of data from a self-rehoming website
Authors: Ly Lexis H , Protopopova Alexandra 
Published: February 2023

AbstractAs animals experience distress in animal shelters, leaders call for increased efforts to divert intake of companion animals away from shelters. One novel intake diversion strategy is supported self-rehoming, where owners find new homes for their animals without surrendering to a physical shelter. This study aimed to identify predictors of successful diversion of animals through the AdoptaPet.com ‘Rehome’ online platform. Data for dogs (n = 100,342) and cats (n = 48,484) were analysed through logistic regression to assess the association of animal- and owner-related factors and outcome. Overall, 87.1% of dogs and 85.7% of cats were successfully diverted from animal shelters, out of which, 37.8% of dogs and 35.3% of cats were kept by their original owner. Multiple animal-related factors predicted increased odds of diversion (e.g. younger, smaller). Dog and cat owners who set a longer rehoming deadline (i.e. > 8 weeks) were over twice as likely to keep or adopt out their animal. Dog owners who surrendered for owner-related reasons had increased odds of diversion in comparison to animal behaviour issues. We conclude that online-supported, self-rehoming platforms provide pet owners with an alternative to relinquishment that may reduce the intake of animals to shelters; however, owners with animals that are not preferred by adopters may have to decide whether to keep their animal or relinquish their animal to a shelter or rescue. These results provide guidance for animal shelter professionals on the likelihood of successful diversion programmes given certain animal and owner characteristics.
Lotze on Comparison and the Unity of Consciousness
Authors: Textor Mark 
Published: February 2023

AbstractHermann Lotze argued that the fact that consciousness simultaneously “holds objects together as well as apart” such that they can be compared implies (a) that there is a simple thinker and (b) that consciousness is an ‘indivisible unity.’ I offer a reconstruction and evaluation of Lotze’s Argument from Comparison. I contend that it does not deliver (a) but makes a good case for (b). I will relate Lotze’s argument to the contemporary debate between “top-down” and “bottom-up” views of the unity of consciousness and locate it in its historical context. (Kant and Herbart figure prominently here.)
The impact of the COVID-19 pandemic on presentations of self-harm over an 18-month period to a tertiary hospital
Authors: O’Malley A. , McIntyre A. , McGilloway A. , Doherty A. , Hallahan B. 
Published: February 2023

AbstractObjectives:To examine and compare rates and methods of self-harm presenting to a tertiary referral hospital during an 18-month period since the onset of the COVID-19 pandemic with a similar period immediately prior to the pandemic onset.Methods:Data from an anonymized database compared rates of self-harm presentations and methods employed between 1st March 2020 and 31st August 2021 to a similar time-frame prior to the onset of the COVID-19 pandemic.Results:A 9.1% increase in presentations with self-harm was noted since the onset of the COVID-19 pandemic. Periods of more stringent restrictions were associated with higher levels of self-harm (daily rate of 2.10 v 0.77). A higher lethality of attempt was demonstrated post-COVID-19 onset (χ2 = 15.38, p < 0.001). Fewer individuals presenting with self-harm were diagnosed with an adjustment disorder since the onset of the COVID-19 pandemic (n = 84, 11.1%, v. n = 112, 16.2%, χ2 = 7.898, p = 0.005), with no other differences pertaining to psychiatric diagnosis noted. More patients actively engaged with mental health services (MHS) presented with self-harm (n = 239 (31.7%) v. n = 137, (19.8%), χ2 = 40.798, p ≤ 0.001) since the onset of the COVID-19 pandemic.Conclusions:Despite an initial reduction, an increase in rates of self-harm has occurred since the onset of the COVID-19 pandemic with higher rates evident during periods of higher government mandated restrictions. An increase in active patients of MHS presenting with self-harm potentially relates to reduced availability of supports and particularly group activities. The recommencement of group therapeutic interventions for individuals attending MHS in particular is warranted.
Are there negative cycles of peer victimization and rejection sensitivity? Testing ri-CLPMs in two longitudinal samples of young adolescents
Authors: Kellij Sanne , Lodder Gerine M.A. , Giletta Matteo , Zimmer-Gembeck Melanie J. , Güroğlu Berna , Veenstra René 
Published: February 2023

AbstractThis study’s aim was to examine whether there are negative increasing cycles of peer victimization and rejection sensitivity over time. Drawing from Social Information Processing Theory, we hypothesized that victimization leads to higher levels of rejection sensitivity, which would put adolescents at risk for higher future victimization. Data were collected in a four-wave study with 233 Dutch adolescents starting secondary education (Mage = 12.7 years), and a three-wave study with 711 Australian adolescents in the last years of primary school (Mage = 10.8 years). Random-intercept cross-lagged panel models were used to disentangle between-person from within-person effects. In each sample, a significant between-person association was found: adolescents with higher levels of victimization as compared to their peers also reported higher levels of rejection sensitivity. At the within-person level, all concurrent associations between individual fluctuations of victimization and rejection sensitivity were significant, but there were no significant cross-lagged effects (except in some sensitivity analyses). These findings demonstrate that victimization and rejection sensitivity are interrelated, but there may not be negative victimization-rejection sensitivity cycles during the early-middle adolescent years. Possibly, cycles establish earlier in life or results are due to shared underlying factors. Further research is needed examining different time lags between assessments, age groups, and contexts.
Physicians Controlling Women’s Reproductive Choices: The Slow Liberalization of Abortion Laws in Finland
Authors: Takala Tuija , Häyry Matti 
Published: February 2023

AbstractThis paper provides an overview of the development and the sociopolitical background of legislation pertaining to abortion in Finland from the nineteenth century to the current day. The first Abortion Act came to force in 1950. Before that, abortions were handled under criminal law. The 1950 law was restrictive and allowed abortions in very limited circumstances only. Its main aim was to reduce the number of abortions and especially illegal abortions. It was not very successful in reaching these goals, but, significantly, it moved abortions from the realm of the criminal law to the hands of medical professionals. The birth of the welfare state and the prenatal attitudes of 1930s and 1940s Europe played their part in shaping the law. By late 1960s, with the rise of the women’s rights movement and other changes in society, there was pressure to change the outdated law. The new 1970 Abortion Act was broader and allowed abortions for limited social reasons too but left very limited, if any, room for a woman’s right to choose. After a citizen’s initiative in 2020, the year 2023 will see a significant amendment to the 1970 law; during the first 12 weeks of pregnancy, an abortion can be performed on the woman’s request alone. However, there is still a long way to go in terms of women’s rights and abortion laws in Finland.