bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improving the Cyclability and Rate Capability of Li4Ti5O12 Anode Material by Cu2+ and F− co‐Doping
Authors: Kahrizi Meisam , Kashani Hamideh , Ghaffarinejad Ali 
Published: February 2023

AbstractWe report a new Li4Ti5−xCuxO11.7F0.3 (X=0.1, 0.15, 0.2, 0.25, 0.3) anodic material for use in Li‐ion batteries. These modified Li4Ti5O12 (LTO) materials were prepared by solid‐state method and calcination at 800 °C. The Li4Ti4.75Cu0.25O11.7F0.3 (LTCu0.25OF0.3), among all samples, shows the best results in cyclability and rate ability. The LTCu0.25OF0.3 delivers discharge capacities of 188.8, 180, 169.7, 151.2, 116, and 93.6 mAh g−1 at 0.1, 0.2, 0.5, 1, 3, and 5C, respectively. The capacity retention of LTO, LTOF0.3, and LTCu0.25OF0.3 after 100 charge and discharge cycles at 1C is 90.8 %, 96.3 %, and 97.7 %, respectively. The enhancement in electrochemical performance of LTCu0.25OF0.3 is attributed to the lower polarization and charge transfer resistance (15.5 Ω) and higher Li+ diffusion coefficient (6.4×10−7 cm2 s−1) obtained by cyclic voltammetry (CV) and electrochemical‐impedance spectra (EIS) tests. This work indicates that Cu2+ and F− have a synergistic impact on the electrochemical properties of LTO.
Construction of Tetrazole Derivatives via Sequential Ugi‐N3/Pd‐Catalyzed Isocyanide Insertion Reactions
Authors: Fan Hao‐Jie , Li A‐Ting , Li Jun , Du Zi‐Qi , Wang Long , Zhou Xian‐Min , He Ping , Ren Zhi‐Lin 
Published: February 2023

AbstractHerein, a straightforward method for the construction of tetrazole derivatives has been achieved through Pd‐catalyzed isocyanide insertion reactions, which is a good extension for the response of multi‐molecule isocyanides. The Ugi‐N3 reaction was introduced to the transformation to enrich the diversity of skeleton structures. The commercially available starting materials and moderate to good yields make this method a valuable tool for generating N‐containing heterocyclic compounds.
One‐Pot Synthesis of Isatin‐Pyrazole Hybrids as VEGFR‐2 Inhibitors and Molecular Docking Studies
Authors: Shreedhar Reddy T. , Rai Sanjay , Kumar Koppula Shiva 
Published: February 2023

AbstractHerein, we described the synthesis of isatin‐pyrazole hybrids (6 a–o) using Acyl‐Sonogashira coupling reaction and evaluated for their in vitro cytotoxicity against three human cancer cell lines such as A549, PC3 and MCF‐7 by using MTT assay and 5‐fluorouracil as the reference drug. Some of the compounds 6 a, 6 j and 6 n were found to be more active than the standard 5‐fluorouracil against three human cancer cell lines. The in vitro VEGFR‐2 tyrosine kinase inhibitory activity reveals that 6 j has exhibited double inhibitory potency with IC50 value of 16.28±1.21 nM compared to reference drug sorafenib and 6 a and 6 n were also shown more inhibition capacity than the standard. Molecular docking studies of the compounds 6 a, 6 j and 6 n towards human VEGFR2 kinase shown that they have good binding interactions with the target protein with binding energies ranging from −10.30 kcal/mol to −10.80 kcal/mol. Finally, the in silico pharmacokinetic profile (ADMET) of potent compounds 6 a, 6 j and 6 n were also studied, where all of them have followed Lipinski rule, Ghose rule, Veber rule, Egan rule and Muegge rule without any deviation and the compounds 6 a and 6 j have shown lead likeness in medicinal chemistry point of view.
Design, Synthesis and Biological Activity of Low‐Molecular‐Weight URAT1 Inhibitors**
Authors: Chen Siliang , Chen Ya , Yang Zhongcheng , Huang Wanqiu , Cao Zhijun , Wang Xuekun , Yao Huixin , Li Zheng , Wang Guangji 
Published: February 2023

AbstractHyperuricemia has become a global problem and is one of the four basic metabolic diseases after hypertension, hyperlipidemia, and hyperglycemia. However, the existing drugs have undesired or serious adverse effects, such as the high risk of Stevens‐Johnson syndrome for allopurinol, and the cardiovascular side effects induced by febuxostat. Therefore, it is an urgent need to develop an effective and safety agent for the treatment of hyperuricemia. The urate transporter 1 (URAT1) inhibitors have been considered as a promising uric acid‐lowering agents. To improve adverse reactions caused by excessive lipophilicity and large molecular weight of existing drugs, five novel low‐molecular‐ weight URAT1 Inhibitors were designed and synthesized by molecular hybridisation. Among them, although compound 4 showed less potent activity than the classic URAT1 inhibitor benzbromarone in vitro, compound 4 exhibited better uric acid‐lowering activity than benzbromarone in vivo, which may be related to the fact that compound 4 has lower lipophilicity than benzbromarone to facilitate drug absorption. In addition, compound 4 cherishes some merits, which have a smaller molecular weight and lower lipophilicity, and superior in vitro activity than lesinurad. Generally, the results indicate that compound 4, with a good therapeutic effect, is a prospective candidate for the treatment of hyperuricemia.
Late‐Stage Borylation Strategy for the Development of New Boron‐Based Retinoids
Authors: Das Bhaskar C. , Yadav Pratik , Das Sasmita , Saito Mariko , Evans Todd 
Published: February 2023

AbstractHerein, we describe the design and synthesis of boron‐based bexarotene analogues as potential new retinoid X receptor (RXR) agonists. The synthetic strategy utilized a common intermediate to access different classes of bexarotene analogues, and subsequently these novel retinoids were borylated. The strategy accomplished synthesis of new classes of borotenoids (boron‐based retinoids) via late‐stage palladium‐catalyzed borylation which could be useful for the development of new therapeutic agents and probes to study retinoic acid signaling pathways.
Time pressure, work‐related spousal support seeking, and relationship satisfaction: Spillover and crossover effects among dual‐earner couples
Authors: Tement Sara , Mihelič Katarina Katja , Kubicek Bettina 
Published: February 2023

AbstractThe present study examined how time pressure at work is transmitted to the home domain and how it affects individuals' (spillover) as well as their partners' relationship satisfaction (crossover). We examined the role of work‐related spousal support seeking and proposed that it serves as a mediator of the spillover as well as the crossover process. We further explored whether the proposed spillover‐crossover process is gender‐contingent. Using a sample of 308 dual‐earner couples, we found support for a positive link between time pressure at work and spousal support seeking. As hypothesised, spousal support seeking served also as a crossover mechanism. However, distinct spillover and crossover processes were found for men and women. These findings not only point to a new spillover and crossover mechanism but also highlight gender‐specific patterns in the role of support seeking. As this coping strategy is feasible when job stressors are high, it should be considered a part of stress management trainings and organizational practices.
Recent Advances on Direct Functionalization of Indoles in Aqueous Media
Authors: Pang Qiwen , Zuo Wei‐Fang , Zhang Yang , Li Xiang , Han Bo 
Published: February 2023

AbstractIndoles and their derivatives have dominated a significant proportion of nitrogen‐containing heterocyclic compounds and play an essential role in synthetic and medicinal chemistry, pesticides, and advanced materials. Compared with conventional synthetic strategies, direct functionalization of indoles provides straightforward access to construct diverse indole scaffolds. As we enter an era emphasizing green and sustainable chemistry, utilizing environment‐friendly solvents represented by water demonstrates great potential in synthesizing valuable indole derivatives. This review aims to depict the critical aspects of aqueous‐mediated indoles functionalization over the past decade and discusses the future challenges and prospects in this fast‐growing field. For the convenience of readers, this review is classified into three parts according to the bonding modes (C−C, C−N, and C−S bonds), which focus on the diversity of indole derivatives, the prominent role of water in the chemical process, and the types of catalyst systems and mechanisms. We hope this review can promote the sustainable development of the direct functionalization of indoles and their derivatives and the discovery of novel and practical organic methods in aqueous phase.
Exosomal miR‐374c‐5p derived from mesenchymal stem cells suppresses epithelial‐mesenchymal transition of hepatocellular carcinoma via the LIMK1‐Wnt/β‐catenin axis
Authors: Ding Bisha , Lou Weiyang , Fan Weimin , Pan Jie 
Published: February 2023

AbstractMetastasis is a leading cause to treatment failure in hepatocellular carcinoma (HCC) patients. Exosomes act as pivotal mediators in communication between different cells and exert effects on recipient cells by delivering bioactive cargoes, such as microRNAs (miRNAs). MiRNAs function in multiple steps of HCC development, including metastasis. MiR‐374c‐5p was previously identified as a tumor suppressor in some malignancies, while the current knowledge of its role in HCC metastasis is still limited. Herein, miR‐374c‐5p was found to be downregulated in HCC cell lines and clinical samples, and positively related with favorable prognosis in HCC patients. MiR‐374c‐5p transferred by exosomes derived from bone marrow mesenchymal stem cell (BMSC) suppressed migration, invasion and proliferation of HCC cells. LIMK1 was verified as downstream target gene of miR‐374c‐5p. Knockdown of LIMK1 reduced invasion, migration and proliferation of HCC cells, whereas overexpression functioned oppositely. The miR‐374c‐5p/LIMK1 axis suppressed epithelial‐mesenchymal transition (EMT) by inactivating Wnt/β‐catenin pathway. In addition, miR‐374c‐5p was downregulated and LIMK1 upregulated in TGF‐β1 induced EMT. This EMT model could be reversed by LIMK1 silencing or miR‐374c‐5p overexpression. These results suggest that exo‐miR‐374c‐5p suppresses EMT via targeting LIMK1‐Wnt/β‐catenin axis and the axis is involved in TGF‐β1 induced metastasis of HCC, thereby identifying miR‐374c‐5p as a potential target for HCC treatment.
Effects of fresh‐cow grouping strategy and rumen‐protected glucose on production performance, reproductive variables and risk of culling in Holstein cows
Authors: Beiranvand H. , Ahmadi F. , Babajanzade‐Sorati S. , Alamouti Ali A. 
Published: February 2023

AbstractBackgroundThe interaction effects of duration of stay in fresh‐cow diet and supplementation with rumen‐protected glucose (RPG) on productivity of dairy cows are largely unknown. We hypothesised that a faster transition from fresh‐cow diet (higher forage:concentrate) to lactation‐cow diet (lower forage:concentrate), combined with supplementation of fresh‐cow diet with RPG will have positive effects on production and health of dairy cows.ObjectivesTo investigate the immediate and long‐term effects of length of stay in fresh‐cow diet and supplementation with RPG on productive and reproductive performance of high‐producing dairy cows.MethodsA total of 264 multiparous Holstein cows (average parity ± standard deviation = 3.2 ± 1.3, ranging from 2 to 6) were used in a 2 × 2 factorially arranged trial. Treatments were the feeding duration of a fresh‐cow diet for 14 or 21 days, each combined by daily supplementation of the fresh‐cow diet with ground corn grain or RPG product top dressed at 500 g/day/head.ResultsThe earlier transition from fresh‐cow to lactation diet resulted in greater milk production from 15 through 21 days in milk (DIM; by 2.28 kg/day), and also fat‐corrected milk production on 30 and 60 DIM, respectively. Corn grain or RPG supplementation did not affect the average milk production (1 to 21 DIM), as well as milk production and composition on 30 and 60 DIM. Although extent of body condition loss at transition tended to be lesser in cows switching faster to lactation diet, these cows lost more body condition from 30 to 90 DIM. Survival analysis on calving‐to‐conception interval and time to removal from herd did not find any significant difference across treatments.ConclusionsThe positive effects of earlier transition from fresh‐cow to lactation diet were evident by greater milk production from 15 through 21 DIM, and fat‐corrected milk production (30 and 60 DIM), at the expense of body condition in high‐producing dairy cows. A daily topdress of RPG on fresh‐cow diet had no immediate or carryover effects on production of dairy cows.
Conservation decision makers worry about relevancy and funding but not climate change
Authors: Jewell Kathryn , Peterson M. Nils , Martin Mallory , Stevenson Kathryn T. , Terando Adam , Teseneer Rachel 
Published: February 2023

AbstractStakeholders fundamentally shape the success of wildlife management, yet little is known about how one of the most important stakeholder groups, wildlife agency decision makers, view emerging conservation challenges. Wildlife agency decision makers collectively shape how wildlife conservation unfolds in North America, but their perspectives are generally absent in the literature. Challenges including climate change, conservation funding models, and wildlife disease make understanding how wildlife decision makers view the future of wildlife conservation essential. We interviewed 48 directors and supervisory board members of wildlife agencies in the southeast United States from July 2019 to January 2020 to gauge their assessment of future conservation challenges and preferred response strategies. Declining agency relevancy and insufficient funding were the 2 most commonly identified challenges, while climate change was rarely mentioned as an issue because decision makers believed it was a relatively slow‐moving background condition. Decision makers described improving relevance through education and outreach as their primary response to conservation challenges. Our results suggest that climate change‐informed wildlife management may benefit from a 2‐pronged approach. First, we suggest decision makers should be informed about the challenges posed by climate change, and second, existing efforts to promote diversity among constituents should include engaging groups who support tackling the threat climate change poses to wildlife conservation. Increasing the priority given to climate change adaptation efforts in wildlife agencies will likely require future research to discern which approaches can most improve the perceived salience of climate change to decision makers.
The parton-level structure of e+e− to 2 jets at N3LO
Authors: Jakubčík Petr , Marcoli Matteo , Stagnitto Giovanni 
Published: February 2023

Abstract
We investigate the quantum chromodynamics (QCD) corrections to hadronic final states in electron-positron collisions at $$ \mathcal{O} $$
O
($$ {\alpha}_s^3 $$

α
s
3

) in the strong coupling constant αs. Namely, we analytically compute the total cross section for this process by separately integrating the tree-level five-parton, the one-loop four-parton, the two-loop three-parton, and the three-loop two-parton matrix elements over the respective phase space. All the contributions to the calculation are treated in a common framework whereby phase space integrals are expressed as physical cuts of the four-loop two-point function. We check the cancellation of infrared poles at all colour levels and we reproduce the known result for the R-ratio at order $$ {\alpha}_s^3 $$

α
s
3

.
A fresh view on string orbifolds
Authors: Giaccari Stefano , Volpato Roberto 
Published: February 2023

Abstract
In quantum field theory, an orbifold is a way to obtain a new theory from an old one by gauging a finite global symmetry. This definition of orbifold does not make sense for quantum gravity theories, that admit (conjecturally) no global symmetries. In string theory, the orbifold procedure involves the gauging of a global symmetry on the world-sheet theory describing the fundamental string. Alternatively, it is a way to obtain a new string background from an old one by quotienting some isometry.We propose a new formulation of string orbifolds in terms of the group of gauge symmetries of a given string model. In such a formulation, the ‘parent’ and the ‘child’ theories correspond to different ways of breaking or gauging all potential global symmetries of their common subsector. Through a couple of simple examples, we describe how the higher group structure of the gauge group in the parent theory plays a crucial role in determining the gauge group and the twisted sector of the orbifold theory. We also discuss the dependence of this orbifold procedure on the duality frame.
Large Time Behavior of Solutions to the 3D Rotating Navier–Stokes Equations
Authors: Egashira Takanari , Takada Ryo 
Published: February 2023

AbstractWe consider the large time behavior of the solutions for the initial value problem of the Navier–Stokes equations with the Coriolis force in the three-dimensional whole space. We show the $$L^p$$

L
p

temporal decay estimates with the dispersion effect of the Coriolis force for the global solutions. Moreover, we prove the large time asymptotic expansion of the solutions behaving like the first-order spatial derivatives of the integral kernel of the corresponding linear solution.
An accuracy evolution method applied to five-axis machining of curved surfaces
Authors: Zha Jun , Villarrazo Nagore , Martínez de Pisson Gonzalo , Li Yipeng , Zhang Huijie , López de Lacalle Luis Norberto 
Published: February 2023

AbstractCurrently, some high-value-added applications involve the manufacturing of curved surfaces, where it is challenging to achieve surface accuracy, repeatability, and productivity simultaneously. Among free-form surfaces, curved surfaces are commonly used in blades and airfoils (with a teardrop-shaped cross-section) and optical systems (with axial symmetry). In both cases, multi-axis milling accuracy directly affects the subsequent process step. Therefore, reducing even insignificant errors during machining can improve the accuracy in the final production stages. This study proposes an “evolution” method to improve the machining accuracy of curved surfaces. The key is to include compensation for the machining error after the first part through profile error measurement. Thus, correction can be applied directly after the manufacturing programming is fully developed, achieving the product with the minimum number of iterations. Accordingly, this method measures the machining error and changes only one key parameter after the process. This study considered two cases. First, an airfoil in which the clamping force was corrected; the results were quite good with only one modification in the blade machining case. Second is an aspherical surface where tool path correction in the Z-axis was applied; the error was effectively compensated along the normal vector of the workpiece surface. The experimental results showed that the surface accuracy increased from 44.4 to 4.5 μm, and the error was reduced by 89.9%, confirming that the accuracy of the machine tool and process had achieved “evolution.” This technical study is expected to help improve the quality and productivity of manufacturing highly accurate curved surfaces.
Entwicklung einer App zur Unterstützung häuslicher Pflegeberatungsbesuche
Authors: Gabber Alexander , Heidenblut Sonja , Gappa Henrike , La Guardia Tim , Zank Susanne 
Published: February 2023

Zusammenfassung
Hintergrund
Die Pflegeberatungsbesuche nach § 37 Absatz 3 SGB XI (PBB) werden bisher uneinheitlich durchgeführt, und es mangelt an einer strukturierten Pflegedokumentation. Im Projekt INGE-integrate4care wurde eine App entwickelt, die die qualitätsgesicherte Durchführung von PBB unterstützen soll.

Methode
Auf Basis eines nutzerzentrierten Designansatzes wurden 10 semistrukturierte Expert:inneninterviews geführt und mittels qualitativer Inhaltsanalyse nach Mayring ausgewertet. In gruppenbasierten Expert:innen-Walkthroughs mit 7 Teilnehmer:innen wurden Design, Inhalte und Funktionen der App diskutiert, Anforderungen in Feedbacklisten gesammelt und von Entwickler:innen digital umgesetzt.

Ergebnisse
Die Interviewten berichteten, dass PBB heterogen seien, es individuelle Herangehensweisen der Pflegefachkräfte (PFK) gebe und sich dies in der Gestaltung der App wiederspiegeln solle. Wichtige Begutachtungsthemen für die App seien z. B. Inhalte des Neuen Begutachtungsassessments (NBA) und die Angehörigenbelastung. Funktionen wie die Empfehlung von Maßnahmen auf Basis dokumentierter Informationen seien wünschenswert. Hinderlich sei dagegen eine zu starre Einhaltung von Bearbeitungsschritten, da diese den Gesprächscharakter der PBB einschränken würden.
Das NBA und BIZA‑D wurden von den Expert:innen im Projekt als passende Basisassessments gewählt und an die PBB angepasst. Zur Unterstützung des Arbeitsablaufs wurden der flexible Zugriff auf Items, die Visualisierung des Pflegestatus je Kategorie sowie die Möglichkeit zu Auswahl und Nachverfolgung von Maßnahmen spezifiziert.

Diskussion
Durch den nutzerzentrierten Designansatz konnte eine App entwickelt werden, die sich sowohl durch Flexibilität als auch Struktur auszeichnet. Das Tool wird mithilfe von Usability-Evaluationen und Fokusgruppen weiter optimiert.
Analysis of image-guided superficial radiation therapy (IGSRT) on the treatment of early-stage non-melanoma skin cancer (NMSC) in the outpatient dermatology setting
Authors: Tran Alison , Moloney Mairead , Kaczmarski Peter , Zheng Songzhu , Desai Alpesh , Desai Tejas , Yu Lio 
Published: February 2023

Abstract
Background
Interest in image-guidance superficial radiation therapy (IGSRT) for the treatment of early-stage non-melanoma skin cancer (NMSC) has resurfaced given its low complication rates, superior cosmesis and local control and cure rates. In addition, it has been recommended by the American Academy of Dermatology (AAD) for early-stage NMSC in patients who are considered poor surgical candidates.

Methods
1899 NMSC lesions were treated with energies ranging from 50 to 100 kilovoltage (kV), for a mean of 20.2 fractions, and treatment dose of 5364.4 centigray (cGy). Lesions were treated for a mean of 7.5 weeks and followed for 65.5 weeks. SAS studio was used to conduct Kaplan–Meier analysis to calculate local control rates and account for differences in follow-up intervals. A log-rank test was used to calculate statistical differences between histologies.

Results
Absolute lesion control was achieved in 99.7% of the patients after an average of 7.5 weeks of treatment, with a stable control rate of 99.6% when the follow-up duration was over 12 months. 95% of lesions with toxicity scoring received a Radiation Treatment Oncology Group Toxicity (RTOG) score of 1 or 2.

Conclusion
IGSRT has a high safety profile, can achieve superior cosmesis and should be considered first-line for treating early-stage NMSC tumors as cure rates have been shown to be effective in all NMSC on early follow-up.