bluuebunny/crossref_metadata_2025_split huggingface dataset:
Retrospective multicentre evaluation of common calcaneal tendon injuries in 66 cats. Part 2: treatment, complications and outcomes
Authors: Häußler Thomas C , Kornmayer Matthias , Scheich Miriam , Fischer Andreas , Feichtenschlager Christian J , Rohwedder Thomas 
Published: January 2023

Objectives The aims of the second part of this retrospective multicentre study were to describe the surgical techniques used in the treatment of common calcaneal tendon (CCT) injuries, and evaluate the short- and long-term outcomes and complications. Methods The medical records of five different small animal referral centres and veterinary teaching hospitals between 2010 and 2020 were reviewed. Surgical vs conservative treatment was evaluated. Treatment type, type of postoperative immobilisation, and short- and long-term outcomes and complications were recorded. Minor complications were defined as not requiring surgical intervention. Long-term outcome was evaluated by an owner questionnaire. Results Sixty-six cats met the inclusion criteria. Mean time to surgery was 9.6 days (range 0–185). Most cats (83.3%) were treated surgically. Regardless of treatment modality, all limbs were immobilised for a mean time of 48.2 days (range 2–98). For 63 cats that had the temporary tarsal joint immobilisation technique recorded, a transarticular external skeletal fixator (ESF; 57.1%) or a calcaneotibial screw (33.3%) were used most commonly. The method of immobilisation had a notable, although non-significant, influence on the occurrence of short-term complications, with most complications being reported for the transarticular ESF group. The total short-term complication rate was 41.3%, the minor complication rate was 33.3% and the major complication rate was 7.9%, with pin tract infections being the most commonly occurring minor complication. Three cats (6%) had a total of four major complications over the long term. Most cats (86%) were free of lameness at the long-term evaluation, with an overall successful clinical long-term outcome of 84.9%, according to the owner questionnaire. Cats with traumatic injuries and injuries treated surgically had higher questionnaire scores than those with atraumatic injuries and those treated conservatively. Conclusions and relevance Outcome was generally good in cats with CCT injury, irrespective of the type of treatment. Complications included a high proportion of minor complications associated with the technique of tarsal joint immobilisation. ESF frames were more commonly involved in complications than other techniques. Surgically treated cats had a slightly better long-term outcomes.
Retrospective multicentre evaluation of common calcaneal tendon injuries in 66 cats. Part 1: study population, injury specification and classification
Authors: Häußler Thomas C , Kornmayer Matthias , Scheich Miriam , Fischer Andreas , Feichtenschlager Christian J , Rohwedder Thomas 
Published: January 2023

Objectives The objective of the first part of this retrospective multicentre study was to identify and classify common calcaneal tendon (CCT) injuries in a study population of 66 cats. Methods The medical records of five different small animal referral centres and veterinary teaching hospitals between 2010 and 2020 were reviewed. In addition to patient-specific data, CCT injuries were characterised in detail. Diagnostic modalities and further comorbidities were recorded. Results Sixty-six cats met the inclusion criteria. The mean age of the cats was 7.5 years (range 0.5–16.3) and their mean body weight (BW) was 4.6 kg (range 1.5–9.0). Thirty-four spayed females (51.5%), five intact females (7.6%) and 27 castrated males (40.9%) were included. Most cases involved closed injuries of the CCT (69.7%). Twenty-one of 46 cats had closed atraumatic injuries (45.7%). Open injuries (30.3%) were most commonly lacerations (65%). Twenty-one injuries were classified as atraumatic (31.8%), whereas 25 were traumatic (37.9%). With every year of age, the odds of having an atraumatic injury increased by a factor of 1.021. Cats with atraumatic injuries had a higher mean BW than cats with traumatic injuries, but the difference was not statistically significant. Acute injuries were recorded in 40.9% of cases, whereas 51.5% of cats had a subacute CCT injury and 7.6% had chronic lesions. Most acute lesions were Meutstege type I injuries (55.6%). Subacute and chronic lesions were more commonly Meutstege type IIc injuries (58.8% and 60%, respectively). Considering all CCT injuries, a Meutstege type IIc injury was most common (53%). Conclusions and relevance The most common type of injury was Meutstege type IIc. Cats with atraumatic injuries had a higher mean BW than cats with traumatic injuries, but the difference was not statistically significant. Older cats more commonly presented with atraumatic CCT injuries.
One Patient With 4 Different Primary Cancers: A Case Report
Authors: Nguyen Dung Thi , Nguyen Lan Mai , Phan Thang Le , Bui Quang Vinh 
Published: January 2023

Background: The development of medicine, especially in oncology, has been helping prolong the cancer patients’ survival, but also leads to increasing the possibility of getting multiple cancers. However, the possibility of getting 4 primary cancers in 4 different sites is extremely rare. Case presentation: A 63-year-old female patient was diagnosed with thyroid cancer in 2018, and then with right colon cancer in 2019. In 2020, this patient was diagnosed with left renal pelvis cancer, and most recently, in April 2022, she was hospitalized with bladder cancer diagnosis. Thanks to being closely and regularly followed-up, her malignancies had been detected early and treated suitably. Her health remains stable now and she is under following-up. Conclusion: Even though developing another primary cancer in a cancer survivor is not uncommon now and has the tendency to increase, a patient having 4 primary cancers in 4 different sites is still extremely rare and should be noticed, further followed up and investigated. Cancer patients and survivors need to be followed-up regularly, to early detect not only the progression or recurrence but also the second cancer (if it exists), to get timely and suitable treatment.
Australian airway clearance services for adults with chronic lung conditions: A national survey
Authors: Cooper Laura , Johnston Kylie , Williams Marie 
Published: January 2023

Background Physiotherapy-led airway clearance interventions are indicated for some people with chronic lung conditions. This study describes Australian clinical models for the provision of adult airway clearance services. Methods This cross-sectional national study recruited public and private health care providers (excluding cystic fibrosis-specific services) identified by a review of websites. Providers were invited to complete an electronic 61-item survey with questions about airway clearance service context, referral demographics, service provision and program metrics. Data were reported descriptively with differences between metropolitan and non-metropolitan services explored with chi-square tests. Results Between October-December 2019, the survey was disseminated to 131 providers with 91 responses received (69% response rate; 87 (96%) public (34 metropolitan; 53 non-metropolitan) and 4 (4%) private). Intent (chronic condition self-management) and types of intervention provided (education, breathing techniques, exercise prescription) were common across all services. Geographic location was associated with differences in airway clearance service models (greater use of regular clinics, telephone/telehealth consultations and dedicated cardiorespiratory physiotherapists in metropolitan locations versus clients incurring service and device provision costs in non-metropolitan regions). Conclusions While similarities in airway clearance interventions exist, differences in service models may disadvantage people living with chronic lung conditions, especially in non-metropolitan regions of Australia.
Sex-Specific Differences in Hip Muscle Cross-sectional Area and Fatty Infiltration in Patients With Femoroacetabular Impingement Syndrome
Authors: Douma Mirjam V. , Casartelli Nicola C. , Sutter Reto , Leunig Michael , Maffiuletti Nicola A. 
Published: January 2023

Background: Patients with femoroacetabular impingement syndrome (FAIS) show sex-specific differences in hip muscle function, hip morphology, and symptoms. Possible differences in hip muscle characteristics between men and women with FAIS are unknown. Purpose: To compare hip muscle cross-sectional area (CSA) and fatty infiltration between men and women with FAIS and investigate possible associations with patient-reported outcomes. Study Design: Cohort study; Level of evidence, 3. Methods: We retrospectively analyzed preoperative axial pelvic magnetic resonance imaging scans of 104 patients (54 women) who underwent hip surgery for FAIS. The main outcome measures were side-to-side percentage asymmetry in hip muscle CSA and involved-side fatty infiltration as measured with the Goutallier scale for a total of 10 hip muscles. Patient-reported outcomes included duration of hip symptoms, iHOT-12 (12-item International Hip Outcome Tool), and Hip Sports Activity Scale. Results: Women showed larger hip abductor muscle CSA asymmetry than men ( P = .018), particularly for the gluteus medius ( P = .049), while men exhibited more fatty streaks (grade 1) in the gluteus medius ( P = .015) than women. Duration of symptoms was associated only with fatty infiltration of obturator externus in men ( r S = –0.55, P = .018). iHOT-12 was associated with CSA asymmetry of the gluteus minimus ( r = –0.41, P = .011) and iliopsoas ( r = –0.36, P = .028) in men and with piriformis fatty infiltration ( r S = –0.56, P = .030) in women. The Hip Sports Activity Scale was associated with iliopsoas CSA asymmetry ( r S = 0.32, P = .026) and with fatty infiltration of the tensor fasciae latae ( r S = –0.45, P = .046) and obturator externus ( r S = –0.50, P = .023) in women. Conclusion: Patients with FAIS demonstrated few sex-specific quantitative and qualitative alterations of hip muscles. Women showed greater hip abductor muscle atrophy than men, particularly for the gluteus medius, while men showed a higher degree of fatty infiltration in this same muscle. The duration of hip symptoms was not associated with muscle atrophy. Patient-reported hip pain/function and sport activity level were only moderately associated with isolated muscular variables.
An Examination of Discrimination on Stress, Depression, and Oppression-Based Trauma During the COVID-19 Pandemic and the Racial Awakening of 2020
Authors: De Leon Ardhys N. , Woerner Jacqueline , Dvorak Robert D. , Cox Jonathan , Magri Tatiana D. , Hayden Emma R. , Ahuja Manik , Haeny Angela M. 
Published: January 2023

Background Discrimination is a pervasive societal issue that monumentally impacts people of color (POC). Many Black, Asian, and Hispanic/Latinx individuals report experiencing race-based discrimination in their lifetime. Discrimination has previously been linked to adverse health outcomes among POC, including stress, depressive, and posttraumatic stress disorder symptoms. These health disparities are posited to have become exacerbated by COVID-19 and the racial awakening of 2020. The current study examined the short- and long-term effects of discrimination on stress, depression, and oppression-based trauma among POC. Methods Participants were (n = 398) who identified as Black, Indigenous, Hispanic/Latinx, and Asian completed an online self-report survey assessing discrimination, depression, stress, and oppression-based trauma collected at 3 time points: (T1) beginning of the COVID-19 pandemic (May 2020), (T2) 6 weeks later during the racial awakening of 2020 (June 2020), (T3) one year later (June 2021). Results Significant positive paths were revealed from T1 discrimination to T2 depression, T2 stress, and T3 oppression-based trauma. The association between T1 discrimination and T3 oppression-based trauma was partially mediated by T2 depression, but not by stress; total and total indirect effects remained significant. The final model accounted for a significant proportion of the variance in T3 oppression-based trauma, T2 depression, and T2 stress. Conclusion Findings are consistent with prior research linking discriminatory experiences with mental health symptomatology and provide evidence that race-based discrimination poses harmful short-and long-term mental health consequences. Further research is necessary to better understand oppression-based trauma to improve the accuracy of clinical diagnosis and treatment of POC.
Radiocapitellar Arthroplasty: Systematic Review
Authors: Momtaz David , Ahmad Farhan , Cushing Tucker , Gonuguntla Rishi , Ghali Abdullah , Jabin Mohamad , Miggins John , Khalafallah Youssef , Mitchell Scott 
Published: January 2023

Introduction Primary elbow osteoarthritis affects approximately 2% of the population, and has been treated with arthroplasty. However, total elbow arthroplasty (TEA) implants currently have severe weight limitations and issues with longevity. In patients with unicompartmental arthritis, unicompartmental arthroplasty may be used instead of TEA. We describe the use of Uni-Elbow Radio-Capitellum and Lateral Resurfacing Elbow for radiocapitellar arthroplasty (RCA) in this article. Methods Reviewers independently searched databases for keywords, such as radiocapitellar arthroplasty, RCA, uni-elbow radiocapitellum, UNI-E, and lateral resurfacing elbow, LRE. The measured outcomes of interest were the change in motion arc and patient-reported outcome scores. Studies that were not of appropriate quality determined by the Cochrane risk of bias summary tool and review studies were excluded. Results RCA resulted in a postoperative 38.3° ± 28.5° increase in elbow flexion-extension ( P < .001), and 35.2° ± 28.6° increase in elbow pronation-supination ( P < .001). Mayo Elbow Performance Score was significantly increased by 44.8 ± 12.6. DASH Score saw a significant reduction by 45.0 ± 14.6 points ( P < .001), while the American Shoulder and Elbow Surgeons Score increased by 47.0 ± 10.6 points ( P < .001). Of the 105 adult patients 16.2% experienced complications such as minor stiffness, ulnar neuropathy, component loosening, or radial head UNI-E stem failure. Reported complications were higher in the UNI-E group than in the LRE group. Conclusion RCA has shown promise as an option to treat radiocapitellar arthritis, particularly when excising the radial head causes lateral column instability.
Diabetes-Related Quality of Life: Learning From Individuals Making Lifestyle Changes to Improve Type 2 Diabetes Control
Authors: Fishman Sarah R. , Fernandez Galvis Maria A. , Linnell Jill , Iribarren Pia , Jonas Victoria H. , Gittleman Jennifer M. , Tanenbaum Molly , Scherer Maya , Weiss Linda , Walker Elizabeth A. , Crespo-Ramos Gladys , Hoogendoorn Claire J. , Pham-Singer Hang , Wu Winfred Y. , Gonzalez Jeffrey S. 
Published: January 2023

Purpose: The purpose of this study was to explore how treatment adherence and lifestyle changes required for glycemic control in type 2 diabetes (T2D) are related to quality of life (QoL) among predominantly ethnic minority and socioeconomically disadvantaged adults engaged in making changes to improve T2D self-management. Methods: Adults with T2D in New York City were recruited for the parent study based on recent A1C (≥7.5%) and randomly assigned to 1 of 2 arms, receiving educational materials and additional self-management support calls, respectively. Substudy participants were recruited from both arms after study completion. Participants (N = 50; 62% Spanish speaking) were interviewed by phone using a semistructured guide and were asked to define QoL and share ways that T2D, treatment, self-management, and study participation influenced their QoL. Interviews were analyzed using thematic analysis. Results: QoL was described as a multidimensional health-related construct with detracting and enhancing factors related to T2D. Detracting factors included financial strain, symptom progression and burden, perceived necessity to change cultural and lifestyle traditions, and dietary and medical limitations. Enhancing factors included social support, diabetes education, health behavior change, sociocultural connection. Conclusion: QoL for diverse and socioeconomically disadvantaged adults with T2D is multifaceted and includes aspects of health, independence, social support, culture, and lifestyle, which may not be captured by existing QoL measures. Findings may inform the development of a novel QoL measure for T2D.
Mechanisms of response and resistance to combined decitabine and ipilimumab for advanced myeloid disease
Authors: Penter Livius , Liu Yang , Wolff Jacquelyn O. , Yang Lin , Taing Len , Jhaveri Aashna , Southard Jackson , Patel Manishkumar , Cullen Nicole M. , Pfaff Kathleen L. , Cieri Nicoletta , Oliveira Giacomo , Kim-Schulze Seunghee , Ranasinghe Srinika , Leonard Rebecca , Robertson Taylor , Morgan Elizabeth A. , Chen Helen X. , Song Minkyung H. , Thurin Magdalena , Li Shuqiang , Rodig Scott J. , Cibulskis Carrie , Gabriel Stacey , Bachireddy Pavan , Ritz Jerome , Streicher Howard , Neuberg Donna S. , Hodi F. Stephen , Davids Matthew S. , Gnjatic Sacha , Livak Kenneth J. , Altreuter Jennifer , Michor Franziska , Soiffer Robert J. , Garcia Jacqueline S. , Wu Catherine J. 
Published: January 2023

Abstract
The challenge of eradicating leukemia in patients with acute myelogenous leukemia (AML) after initial cytoreduction has motivated modern efforts to combine synergistic active modalities including immunotherapy. Recently, the ETCTN/CTEP 10026 study tested the combination of the DNA methyltransferase inhibitor decitabine together with the immune checkpoint inhibitor ipilimumab for AML/myelodysplastic syndrome (MDS) either after allogeneic hematopoietic stem cell transplantation (HSCT) or in the HSCT-naïve setting. Integrative transcriptome-based analysis of 304 961 individual marrow-infiltrating cells for 18 of 48 subjects treated on study revealed the strong association of response with a high baseline ratio of T to AML cells. Clinical responses were predominantly driven by decitabine-induced cytoreduction. Evidence of immune activation was only apparent after ipilimumab exposure, which altered CD4+ T-cell gene expression, in line with ongoing T-cell differentiation and increased frequency of marrow-infiltrating regulatory T cells. For post-HSCT samples, relapse could be attributed to insufficient clearing of malignant clones in progenitor cell populations. In contrast to AML/MDS bone marrow, the transcriptomes of leukemia cutis samples from patients with durable remission after ipilimumab monotherapy showed evidence of increased infiltration with antigen-experienced resident memory T cells and higher expression of CTLA-4 and FOXP3. Altogether, activity of combined decitabine and ipilimumab is impacted by cellular expression states within the microenvironmental niche of leukemic cells. The inadequate elimination of leukemic progenitors mandates urgent development of novel approaches for targeting these cell populations to generate long-lasting responses. This trial was registered at www.clinicaltrials.gov as #NCT02890329.
Clinical characteristics and positive airway pressure adherence among elderly European sleep apnoea patients from the ESADA cohort
Authors: Lammintausta Aino , Anttalainen Ulla , Basoglu Özen K. , Bonsignore Maria R. , Gouveris Haralampos , Grote Ludger , Hedner Jan , Ludka Ondrej , Mihaicuta Stefan , Pataka Athanasia , Trakada Georgia , van Zeller Mafalda , Saaresranta Tarja 
Published: January 2023

BackgroundThe prevalence of obstructive sleep apnoea (OSA) is growing as the population is ageing. However, data on the clinical characteristics of elderly patients with OSA and their adherence to positive airway pressure (PAP) treatment are scarce.MethodsData from 23 418 30–79-year-old OSA patients prospectively collected into the ESADA database during 2007–2019 were analysed. Information on PAP use (h·day−1) in association with a first follow-up visit was available for 6547 patients. The data was analysed according to 10-year age groups.ResultsThe oldest age group was less obese, less sleepy and had a lower apnoea–hypopnoea index (AHI) compared with middle-aged patients. The insomnia phenotype of OSA was more prevalent in the oldest age group than in the middle-aged group (36%, 95% CI 34–38versus26%, 95% CI 24–27, p<0.001). The 70–79-year-old group adhered to PAP therapy equally well as the younger age groups with a mean PAP use of 5.59 h·day−1(95% CI 5.44–5.75). PAP adherence did not differ between clinical phenotypes based on subjective daytime sleepiness and sleep complaints suggestive of insomnia in the oldest age group. A higher score on the Clinical Global Impression Severity (CGI-S) scale predicted poorer PAP adherence.ConclusionThe elderly patient group was less obese, less sleepy, had more insomnia symptoms and less severe OSA, but were rated to be more ill compared with the middle-aged patients. Elderly patients with OSA adhered to PAP therapy equally well as middle-aged patients. Low global functioning (measured by CGI-S) in the elderly patient predicted poorer PAP adherence.
Registry on the Treatment of Central and Complex Sleep-Disordered Breathing with Adaptive Servo-Ventilation (READ-ASV): protocol and cohort profile
Authors: Arzt Michael , Munt Oliver , Pépin Jean-Louis , Heinzer Raphael , Kübeck Raphaela , von Hehn Ulrike , Ehrsam-Tosi Daniela , Benjafield Adam , Woehrle Holger 
Published: January 2023

BackgroundAlthough adaptive servo-ventilation (ASV) effectively supresses central sleep apnoea (CSA), little is known about real-world indications of ASV therapy and its effects on quality of life (QoL).MethodsThis report details the design, baseline characteristics, indications for ASV and symptom burden in patients enrolled in the Registry on the Treatment of Central and Complex Sleep-Disordered Breathing with Adaptive Servo-Ventilation (READ-ASV). This multicentre, European, non-interventional trial enrolled participants prescribed ASV in clinical practice between September 2017 and March 2021. An expert review board assigned participants to ASV indications using a guideline-based semi-automated algorithm. The primary end-point was change in disease-specific QoL based on the Functional Outcomes of Sleep Questionnaire (FOSQ) from baseline to 12-month follow-up.ResultsThe registry population includes 801 participants (age 67±12 years, 14% female). Indications for ASV were treatment-emergent or persistent CSA (56%), CSA in cardiovascular disease (31%), unclassified CSA (2%), coexisting obstructive sleep apnoea and CSA (4%), obstructive sleep apnoea (3%), CSA in stroke (2%) and opioid-induced CSA (1%). Baseline mean apnoea­–hypopnoea index was 48±23 events·h−1(≥30 events·h−1in 78%), FOSQ score was 16.7±3.0 (<17.9 in 54%) and Epworth Sleepiness Scale (ESS) score was 8.8±4.9 (>10 in 34%); 62% of patients were symptomatic (FOSQ score <17.9 or ESS score >10).ConclusionThe most common indications for ASV were treatment-emergent or persistent CSA or CSA in cardiovascular disease (excluding systolic heart failure). Patients using ASV in clinical practice had severe sleep-disordered breathing and were often symptomatic. One-year follow-up will provide data on the effects of ASV on QoL, respiratory parameters and clinical outcomes in these patients.