bluuebunny/crossref_metadata_2025_split huggingface dataset:
Is the development of personality beliefs related to childhood traumas and emotional intelligence levels?: A prospective cross-sectional study
Authors: MADEN Ozgur 
Published: August 2023

Abstract

Background
In this study, it was aimed to determine whether there is a relationship between childhood traumas and emotional intelligence levels and personality beliefs.
Methods
University students who applied for a health board examination, did not have any psychiatric disease history, had childhood trauma (CT (+), 45.0%, n = 174) and had no childhood trauma (CT (-), 55.0%, n = 213) were included in the study. students participated. Sociodemographic data form and Childhood Trauma Scale, Bar-On Emotional Intelligence Scale and Personality Beliefs Scale were given to the participants. Statistical analysis was performed using the SPSS (ver.22.0, Chicago, II, USA) program.
Results
Of the students, 91.0% (n = 352) were male and 46.3% (n = 179) were in the 20–21 age group. Most of them were studying at the faculty of engineering. In those with CT (+), avoidant-personality beliefs, dependent-personality beliefs, passive-aggressive-personality beliefs, antisocial-personality beliefs, histrionic-personality beliefs, schizoid-personality beliefs, paranoid-personality beliefs and borderline-personality beliefs levels and intrapersonal skills, interpersonal skills, adaptability, stress management and general mood emotional intelligence levels were statistically significant compared to those with CT (-) degree was higher. A moderate, positive, statistically significant relationship was found between childhood trauma levels and personality beliefs and emotional intelligence levels, excluding obsessive-compulsive personality beliefs. Furthermore, there was no statistically significant relationship between obsessive-compulsive-personality beliefs and emotional intelligence levels in those with childhood traumas.
Conclusion
Childhood traumas, which can be effective in personality development, may contribute to the development of different components of emotional intelligence and different personality beliefs. Different dimensions of emotional intelligence can also be effective in the emergence of personality beliefs. We would like to emphasize that childhood traumas and emotional intelligence levels are not related to the emergence of obsessive-compulsive beliefs.
Investigating the Potential of 6-Substituted 3-Formyl Chromone Derivatives as Anti-Diabetic Agents Using DFT, Molecular Docking and Molecular Dynamics Methods
Authors: Saif Minhaz Zabin , Esha Nusrat Jahan Ikbal , Quayum Syeda Tasnim , Rahman Shofiur , Al-Gawati Mahmoud , Alsowygh Ghadah , Albrithen Hamad , Alodhayb Abdullah , Poirier Raymond A. , Uddin Kabir M. 
Published: August 2023

Abstract
The focus of this research is to investigate the potential of 6-substituted 3-formyl chromone derivatives (1-16) for various biological activities such as antifungal, antiviral, antibacterial, antiallergenic etc. The research examined the formyl group at the chromone’s C-3 position. ADMET, biological activities, were conducted along with B3LYP calculations using 3 different basis sets. The analogues were analyzed based on their parent structure obtained from PubChem. The HOMO-LUMO gap confirmed the bioactive nature of the derivatives, NBO analysis was performed to understand the charge transfer. PASS prediction revealed that 3-formyl chromone derivatives are potent aldehyde oxidase inhibitors, insulin inhibitors, HIF1A expression inhibitors, and histidine kinase. Molecular docking studies indicated that the compounds had a strong binding affinity with proteins, including CAD, BHK, IDE, HIF-α, p53, COX, and Mpro of SARS-CoV2. 6-isopropyl-3-formyl chromone (4) displayed the highest affinity for IDE, with a binding energy of -8.5 kcal mol⁻¹. This result outperformed the affinity of the reference standard dapagliflozin (-7.9 kcal mol⁻¹) as well as two other compounds that target human IDE, namely vitexin (-8.3 kcal mol⁻¹) and myricetin (-8.4 kcal mol⁻¹). MD simulations were revealed RMSD value between 0.2 and 0.5 nm, indicating the strength of the protein-ligand complex at the active site.
Augmenting MEK inhibitor Efficacy in BRAF Wild-Type Melanoma: Synergistic Effects of Disulfiram Combination Therapy
Authors: Meraz-Torres Francisco , Niessner Heike , Plöger Sarah , Riel Simon , Schörg Barbara , Casadei Nicolas , Kneilling Manfred , Schaller Martin , Flatz Lukas , Macek Boris , Eigentler Thomas , Rieß Olaf , Garbe Claus , Amaral Teresa , Sinnberg Tobias 
Published: August 2023

Abstract
Background
MEK inhibitors (MEKi) were shown to be clinically insufficiently effective in patients suffering from BRAF wild-type (BRAF WT) melanoma, even if the MAPK pathway was constitutively activated due to mutations in NRAS or NF-1. Thus, novel combinations are needed to increase the efficacy and duration of response to MEKi in BRAF WT melanoma. Disulfiram and its metabolite diethyldithiocarbamate are known to have antitumor effects related to cellular stress, and induction of endoplasmic reticulum (ER) stress was found to synergize with MEK inhibitors in NRAS-mutated melanoma cells. Therefore, we investigated the combination of both therapeutics to test their effects on BRAF-WT melanoma cells and compared them with monotherapy using the MEKi trametinib.
Methods
The effects of combined therapy with disulfiram or its metabolite diethyldithiocarbamate and the MEKi trametinib were evaluated in a series of BRAF-WT melanoma cell lines by measuring cell viability and apoptosis induction. Cytotoxicity was additionally assessed in 3D spheroids, ex vivo melanoma slice cultures, and in vivo xenograft mouse models. The response of melanoma cells to treatment was studied at the RNA and protein levels to decipher the mode of action. Intracellular and intratumoral copper measurements were performed to investigate the role of copper ions in the antitumor cytotoxicity of disulfiram and its combination with the MEKi.
Results
Diethyldithiocarbamate enhanced trametinib-induced cytotoxicity and apoptosis induction in 2D and 3D melanoma culture models. Mechanistically, copper-dependent induction of oxidative stress and ER stress led to Janus kinase (JNK)-mediated apoptosis in melanoma cells. This mechanism was also detectable in patient-derived xenograft melanoma models and resulted in a significantly improved therapeutic effect compared to monotherapy with the MEKi trametinib.
Conclusions
Disulfiram and its metabolite represent an attractive pharmaceutical approach to induce ER stress in melanoma cells that potentiates the antitumor effect of MEK inhibition and may be an interesting candidate for combination therapy of BRAF WT melanoma.
Quantitative differentiation of non-invasive bladder urothelial carcinoma and inverted papilloma based on CT urography
Authors: Jin Pengfei , Yang Liqin , Liu Yitao , Huang Jiehui , Wang Xu 
Published: August 2023

Abstract
Purpose
To investigate the value of CT urography (CTU) indicators in the quantitative differential diagnosis of bladder urothelial carcinoma (BUC) and inverted papilloma of the bladder (IPB).
Material and methods
Retrospective analysis of clinical and imaging data of 103 patients who underwent CTU prior to transurethral resection of the bladder tumor or radical cystectomy from January 2019 to December 2022. The imaging data included 6 qualitative indicators and 7 quantitative measures. The recorded clinical information and imaging features were subjected to univariate and multivariate logistic regression analysis to find independent risk factors for BUC, and a combined multi-indicator prediction model was constructed, and the prediction model was visualized using nomogram. ROC curve analysis was used to calculate and compare the predictive efficacy of independent risk factors and nomogram.
Results
Junction smoothness, maximum longitudinal diameter, tumor-wall interface and arterial reinforcement rate were independent risk factors for distinguishing BUC from IPB. The AUC of the combined model was 0.934 (sensitivity = 0.808, specificity = 0.920, accuracy = 0.835), and its diagnostic efficiency was higher than that of junction smoothness (AUC = 0.667, sensitivity = 0.654, specificity = 0.680, accuracy = 0.660), maximum longitudinal diameter (AUC = 0.757, sensitivity = 0.833, specificity = 0.604, accuracy = 0.786), tumor-wall interface (AUC = 0.888, sensitivity = 0.755, specificity = 0.808, accuracy = 0.816) and Arterial reinforcement rate (AUC = 0.786, sensitivity = 0.936, specificity = 0.640, accuracy = 0.864).
Conclusion
Above qualitative and quantitative indicators based on CTU and the combination of them may be helpful to the differential diagnosis of BUC and IPB, thus better assisting in clinical decision-making.
Comparative Studies on the Seismic Performances of Precast Segmental Columns with Different Concrete, Reinforcement and Tendon Materials
Authors: Li Canjun , Bi Kaiming , Hao Hong , Li Chao 
Published: August 2023

Abstract

In recent years, precast segmental columns cast with Portland cement concrete (OPC) and reinforced with steel rebars have gained popularity in engineering practices owing to its obvious advantages. However, the use of OPC in the construction associates to significant emission of carbon dioxide. Moreover, the corrosion of steel reinforcements and tendon are unavoidable during the lifetime of the structure, which will significantly lower the structural strength and durability. To overcome these issues, very recently, we have proposed using green and sustainable construction materials, i.e., the geopolymer concrete (GPC), together with basalt fibre reinforced polymer (BFRP) reinforcements and tendons, which possess the characteristics of less CO2 emission and excellent corrosion resistant capability, to construct precast segmental columns (i.e., to construct GPC-BFRP segmental columns) for seismic resistant applications. Experimental studies on the proposed GPC-BFRP and the conventional OPC-steel segmental columns were then performed to examine the performances of the proposed design. However, the comparisons of the experimental results were not strictly fair since the key parameters of the two types of columns, e.g., concrete strength and posttension force, in the experiments could not exactly be the same even though they were designed to be the same. This paper therefore extends the recent experimental study and performs numerical simulations. In particular, the experimentally tested columns were used to validate the three-dimensional (3D) finite element models (FEMs) of the two segmental columns with different materials (i.e., OPC-steel and GPC-BFRP). The validated numerical models are then used to examine the seismic performances of these two types of columns under the same design parameters. Numerical results show that under small earthquakes, the two types of columns present almost identical structural responses. Under moderate to severe earthquakes, the two columns also have comparable performances, but GPC-BFRP segmental column presents slightly larger displacement responses and failed slightly earlier because of the smaller BFRP elastic modulus. The results in this study demonstrate the potentials of constructing sustainable and durable GPC-BFRP segmental columns in seismic regions.
Comparative study of the effect of different treatments on infestation development by the red palm weevil Rhynchophorus ferrugineus (Olivier) in Tunisia
Authors: Ouali Othmen , Slimane-Kharrat Saida , Rahmouni Mohamed , Boughanmi Néziha Ghanem 
Published: August 2023

Abstract
Since its entry into Tunisia in 2010, the red palm weevil has dispersed to many parts of the country and killed thousands of canary palms. The purpose of this study is to test several treatment models of RPW control strategies in order to deduce which strategy is the most effective, efficient, ecological and least expensive. These experiments lasted one year and according to the obtained results, the foliar treatments can be reduced from 12 times to 8 times only without having any difference in the evolution of the infestation of this pest. It can have less environmental impact and can make more money. Endotherapy demonstrate a relevant efficacy in the treatment of palm trees, except that specialists should do it in accordance with the rules of the art. Confidor 200 SL prove to be efficacious because the treated palms have not evolved only from 3 months of treatment, so the latter is effective for a duration of only 3 months, Furthermore, the Pro Act 50 CE has at least 7 months of palm protection. On the other hand, foliar treatment in combination with endotherapy did not significantly change the results compared to endotherapy alone. Using pheromone traps with foliar treatments and endotherapies with confidor 200 SL did not show much of a difference from endotherapy alone. In the case of the Pro Act 50 EC, there is no major difference either. Using traps, foliar treatments should be performed to protect the palms from new infestations by females that have won the palms without the traps. This triple treatment in the long term proves effective. Finally, for all stage 4 palms (umbrella) no treatment is curative.
Investigation of the role of rs4238001 genetic polymorphism of SR-B1 gene on serum level of lipids in Iraqi patients with myocardial infarction treated with rosuvastatin
Authors: Abdulfattah shaimaa , Alagely Huda , Samawi Farah 
Published: August 2023

Abstract
The scavenger receptor type B (SR-BI) is a receptor that binds both native and altered lipoproteins. It was revealed to facilitate the utilization of high-density lipoprotein HDL and significantly affect the reverse transport of cholesterol. The present work aims to explore the risk of rs4238001, a nonsynonymous genetic variant in patients of ischemic heart disease (IHD), diagnosis with myocardial infarction, and how this variant could perhaps impact the response of rosuvastatin drug. The genotyping of the rs4238001 genetic polymorphism of the SR-B1 gene was performed in 300 participants, including 150 MI patients treated with 20mg/day/4 weeks of rosuvastatin and 150 healthy using Taq man probes (FAM probe for common C allele and VIC probe for mutant T allele) by Real time-PCR technique. The concentrations of the lipid profile were evaluated. The significance of the anthropometric data was revealed in the ejection fraction and smoking status (p < 0.05) between groups. The lipid profile shows either significant differences between control and MI patient (pre-treatment) or between pre-and post-treatment of MI patients (p < 0.05), but not HDL-c (p > 0.05). The minor allele frequency MAF% of the T allele and TT genotype were more frequent in MI patients than in controls (P = 0.173; OR = 3.62; 95%CI = 0.74–17.64). CC genotype was found to be associated with response to rosuvastatin therapy with a change of % (29.08 ± 53.2; p = 0.021). In the Iraqi population, the rs4238001 polymorphism of the SR-B1 gene is associated with variations in serum lipids, and the CC genotype of the SNP is related to higher HDL-C in the lipid-lowering rosuvastatin response.
Remote Sensing Image Change Detection based on Cross Mixing Attention Network
Authors: WU Xiaosuo , YANG Le , WU Chaoyang , GUO Cunge , WANG Liling , YAN Haowen 
Published: August 2023

Abstract
Change detection is a crucial undertaking in the field of remote sensing. Current change detection methods tend to emphasize modelling difference features, ignoring the alignment error of dual-temporal images and the spatio-temporal relationship between dual-temporal images, which affects the recognition ability of features and makes it difficult to distinguish the real change region. Aiming at the above problems, this paper proposes a remote sensing image change detection method based on cross mixing attention network. The method employs the feature alignment module to obtain dual-temporal correction features to improve the classification effect of the boundary pixels of the target region. The spatio-temporal relationship of the dual-temporal phase images is better exploited by the cross mixing attention module to obtain attention maps at different scales to guide the up-sampling and enhancing the detection performance of target areas at different scales. Our introduced network demonstrates promising performance, as evidenced by extensive experimental results on both the LEVIR-CD dataset and SYSU-CD dataset.
Applicability and Clinical Utility of the German Rivermead Post-Concussion Symptoms Questionnaire in Proxies of Children after Traumatic Brain Injury: An Instrument Validation Study
Authors: Bockhop Fabian , Greving Sven , Zeldovich Marina , Krenz Ugne , Cunitz Katrin , Timmermann Dagmar , Kieslich Matthias , Andelic Nada , Buchheim Anna , Koerte Inga K. , Roediger Maike , Brockmann Knut , Bonfert Michaela V. , Berweck Steffen , Lendt Michael , Staebler Michael , von Steinbuechel Nicole 
Published: August 2023

Abstract

Background. The German Rivermead Post-Concussion Symptoms Questionnaire (RPQ) can be used to assess post-concussion symptoms (PCS) after traumatic brain injury (TBI) in adults, adolescents, and children.
Methods. In this study, we examined the psychometric properties of the German RPQ proxy version (N = 146) for children (8—12 years) after TBI on the item, total and scale score level. Construct validity was analyzed using rank correlations with the proxy-assessed Post-Concussion Symptoms Inventory (PCSI-P), the Patient Health Questionnaire 9 (PHQ-9), and the Generalized Anxiety Disorder Scale 7 (GAD-7). Furthermore, sensitivity testing concerning subjects’ sociodemographic and injury-related characteristics was performed. Differential item functioning (DIF) was conducted to evaluate the comparability of RPQ proxy ratings in children compared to adolescents.
Results. Good internal consistency was shown regarding Cronbach’s α (0.81—0.90) and McDonald’s ω (0.84—0.92). Factorial validity was superior for a three-factor model compared to the original one-factor model. Proxy ratings of the RPQ total and scale scores had strong correlations with the PCSI-P (ϱ = 0.50—0.69), as well as moderate to strong correlations with the PHQ-9 (ϱ = 0.49—0.65) and the GAD-7 (ϱ = 0.44—0.64). DIF analysis revealed no relevant differences between children and adolescent proxy versions.
Conclusions: The German RPQ proxy is a psychometrically reliable and valid instrument to assess PCS in children after TBI. Therefore, RPQ self- and proxy-ratings can be used to assess PCS in childhood as well as along the lifespan of an individual after TBI.
The burden of mental, and substance use disorders in Saudi Arabia: results from the Global Burden of Disease Study 2019
Authors: Ramadan Majed , Aboalola Doaa A. , Alsiary Rawiah , Batwa Yara F. 
Published: August 2023

AbstractBackground Mental and substance use disorders represent a significant global public health challenge causing considerable morbidity and mortality worldwide. This paper assessed the prevalence, incidence, and trends in disability-adjusted life-years (DALYs) rates due to mental and substance use disorders over a 30-year period in Saudi Arabia. Method This is a systematic analysis of the Global Burden of Disease (GBD) 2019 study. Data for the disease burden of mental and substance use disorders were used to Saudi Arabia from 1990 to 2019. Results In 2019, there were 5,032,669 million (95% uncertainty intervals (UI) 3·5–9·9)) adults in Saudi Arabia with mental disorder, and 166,989 thousand with substance use disorder. The largest proportion of prevalence increase from 1990 to 2019 was in eating disorder with 9.8% (95% UI 7.03–12.6). The most significant proportion of prevalence and incidence increase from 1990 to 2019 was in opioid disorders with 69.72% (95% UI 67-72.5), 42.14% (95% UI 32.414–54.75). Gender and age variations were observed in the DALYs due to mental and substance use disorders. From 1990 to 2019 there was + 26.46% increase in the annual change rate of age standardized DALYs due to substance use disorders Conclusion This study highlights the modest increase in the prevalence, incidence, and disability-adjusted life years (DALYs) rates associated with mental disorders in Saudi Arabia over the past three decades. However, there has been a significant rise in the prevalence, incidence, and DALYs rates related to substance use disorders across different gender and age groups. These findings underscore the significance of taking into account age and gender differences in mental and substance use disorders when formulating prevention and treatment initiatives. Further research is warranted to identify the factors contributing to the upward trend in substance use disorders and to devise effective strategies for addressing this critical public health concern.
High Intensity Interval Training (HIIT) Ameliorates the Tramadol-Induced Nephrotoxicity and Oxidative Stress in Experimental Rats
Authors: Hosseini Najmeh Sadat , Meymandi Manzumeh Shamsi , Sepehri Gholamreza , Dabiri Shahriar , Shirazpour Sara , Zangiabadizadeh Mahla , Bashiri Hamideh 
Published: August 2023

Abstract
Introduction: Tramadol (TRA) is an opioid analgesic widely prescribed for moderate to severe pain; however, its chronic use is associated with kidney damage. Objectives: This study aimed to assess the impacts of high intensity interval training (HIIT) on the male rat's kidney following chronic TRA administration. Methods: In this experimental study, 30 male Wistar rats were assigned to the following groups: CON; animals received normal saline five days a week in the first month and three days a week second month, EXE; animals conducted (HIIT) according to exercise protocol five days a week for two months, TRA; animals received tramadol 50 mg/kg (i.p.) as described for the CON group. TRA-EXE; animals received tramadol and conducted exercise protocol, and EXE-SL; animals received normal saline and conducted exercise protocol. Then serum malondialdehyde (MDA), total antioxidant capacity (TAC), Glutathione peroxidase (GPx), superoxide dismutase (SOD), albumin (ALB), urea, creatinine (CR), and tissue level of TNFα, IL-6, IL-10 with pathological changes in kidney were measured. P < 0.05 was considered significant using Graph-pad Prism v.9. Results: Exercise in TRA-EXE group increased significantly IL-10, IL-6, MDA, urea, and CR levels compared with TRA group (but not compared to CON). As well, SOD, TAC, GPx, and ALB levels were decreased significantly in TRA-EXE compared with TRA group (but not compared to CON). Pathological findings showed increased inflammatory effect of HIIT even in EXE-TRA due to severe hyperemia seen in all exercise groups. Other findings were in line with the above results. Conclusion: The results showed that HIIT was able to reverse most of harmful effects of tramadol on kidney, including tramadol-induced apoptosis, oxidative stress, and kidney function indices. However, HIIT may lead to increased inflammation, unlike chronic use of tramadol which appeared to ameliorate inflammation. Finally, HIIT might be proposed as a therapeutic strategy for chronic users of tramadol.