bluuebunny/crossref_metadata_2025_split huggingface dataset:
CD4+ T cell-induced inflammatory cell death controls immune-evasive tumours
Authors: Kruse Bastian , Buzzai Anthony C. , Shridhar Naveen , Braun Andreas D. , Gellert Susan , Knauth Kristin , Pozniak Joanna , Peters Johannes , Dittmann Paulina , Mengoni Miriam , van der Sluis Tetje Cornelia , Höhn Simon , Antoranz Asier , Krone Anna , Fu Yan , Yu Di , Essand Magnus , Geffers Robert , Mougiakakos Dimitrios , Kahlfuß Sascha , Kashkar Hamid , Gaffal Evelyn , Bosisio Francesca M. , Bechter Oliver , Rambow Florian , Marine Jean-Christophe , Kastenmüller Wolfgang , Müller Andreas J. , Tüting Thomas 
Published: June 2023

AbstractMost clinically applied cancer immunotherapies rely on the ability of CD8+ cytolytic T cells to directly recognize and kill tumour cells1–3. These strategies are limited by the emergence of major histocompatibility complex (MHC)-deficient tumour cells and the formation of an immunosuppressive tumour microenvironment4–6. The ability of CD4+ effector cells to contribute to antitumour immunity independently of CD8+ T cells is increasingly recognized, but strategies to unleash their full potential remain to be identified7–10. Here, we describe a mechanism whereby a small number of CD4+ T cells is sufficient to eradicate MHC-deficient tumours that escape direct CD8+ T cell targeting. The CD4+ effector T cells preferentially cluster at tumour invasive margins where they interact with MHC-II+CD11c+ antigen-presenting cells. We show that T helper type 1 cell-directed CD4+ T cells and innate immune stimulation reprogramme the tumour-associated myeloid cell network towards interferon-activated antigen-presenting and iNOS-expressing tumouricidal effector phenotypes. Together, CD4+ T cells and tumouricidal myeloid cells orchestrate the induction of remote inflammatory cell death that indirectly eradicates interferon-unresponsive and MHC-deficient tumours. These results warrant the clinical exploitation of this ability of CD4+ T cells and innate immune stimulators in a strategy to complement the direct cytolytic activity of CD8+ T cells and natural killer cells and advance cancer immunotherapies.
Children’s dental panoramic radiographs dataset for caries segmentation and dental disease detection
Authors: Zhang Yifan , Ye Fan , Chen Lingxiao , Xu Feng , Chen Xiaodiao , Wu Hongkun , Cao Mingguo , Li Yunxiang , Wang Yaqi , Huang Xingru 
Published: June 2023

AbstractWhen dentists see pediatric patients with more complex tooth development than adults during tooth replacement, they need to manually determine the patient’s disease with the help of preoperative dental panoramic radiographs. To the best of our knowledge, there is no international public dataset for children’s teeth and only a few datasets for adults’ teeth, which limits the development of deep learning algorithms for segmenting teeth and automatically analyzing diseases. Therefore, we collected dental panoramic radiographs and cases from 106 pediatric patients aged 2 to 13 years old, and with the help of the efficient and intelligent interactive segmentation annotation software EISeg (Efficient Interactive Segmentation) and the image annotation software LabelMe. We propose the world’s first dataset of children’s dental panoramic radiographs for caries segmentation and dental disease detection by segmenting and detecting annotations. In addition, another 93 dental panoramic radiographs of pediatric patients, together with our three internationally published adult dental datasets with a total of 2,692 images, were collected and made into a segmentation dataset suitable for deep learning.
Nesting biology and phylogenetic relationships of the parasitoid-hunting wasp Lindenius pygmaeus armatus (Vander Linden, 1829) (Hymenoptera: Crabronidae)
Authors: Olszewski Piotr , Budrys Eduardas , Orlovskytė Svetlana , Wiśniowski Bogdan , Ljubomirov Toshko 
Published: June 2023

AbstractNests ofLindenius pygmaeus armatuswere examined in northern Poland in Kowalewo Pomorskie and Sierakowo. Adults were encountered from late May to late July. The nests were built in sandy areas and wasteland. Seven nests were observed, of which two were dug up and their structure was examined. The channel was approximately 2.5 mm in diameter and 8–10 cm in the length. The material removed during digging was placed near the nest entrance. The main burrow led to 3–5 cells. The cocoons were approximately 5–7 mm long and 2.5–3.5 mm wide. Females ofL. p. armatusprovided their nest cells with chalcid wasps averaging 14 prey items per cell. ParasitoidsMyrmosa atraand kleptoparasitesSenotainia conicawere observed entering the burrows. Both females and males ofL. p. armatuswere detected on the flowers ofAchillea millefolium,Peucedanum oreoselinum,Daucus carota, andTanacetum vulgare. The article also includes phylogenetic relationships of Western PalearcticLindeniusspecies.
Compositional modeling of gas-condensate viscosity using ensemble approach
Authors: Rezaei Farzaneh , Akbari Mohammad , Rafiei Yousef , Hemmati-Sarapardeh Abdolhossein 
Published: June 2023

AbstractIn gas-condensate reservoirs, liquid dropout occurs by reducing the pressure below the dew point pressure in the area near the wellbore. Estimation of production rate in these reservoirs is important. This goal is possible if the amount of viscosity of the liquids released below the dew point is available. In this study, the most comprehensive database related to the viscosity of gas condensate, including 1370 laboratory data was used. Several intelligent techniques, including Ensemble methods, support vector regression (SVR), K-nearest neighbors (KNN), Radial basis function (RBF), and Multilayer Perceptron (MLP) optimized by Bayesian Regularization and Levenberg–Marquardt were applied for modeling. In models presented in the literature, one of the input parameters for the development of the models is solution gas oil ratio (Rs). Measuring Rs in wellhead requires special equipment and is somewhat difficult. Also, measuring this parameter in the laboratory requires spending time and money. According to the mentioned cases, in this research, unlike the research done in the literature, Rs parameter was not used to develop the models. The input parameters for the development of the models presented in this research were temperature, pressure and condensate composition. The data used includes a wide range of temperature and pressure, and the models presented in this research are the most accurate models to date for predicting the condensate viscosity. Using the mentioned intelligent approaches, precise compositional models were presented to predict the viscosity of gas/condensate at different temperatures and pressures for different gas components. Ensemble method with an average absolute percent relative error (AAPRE) of 4.83% was obtained as the most accurate model. Moreover, the AAPRE values for SVR, KNN, MLP-BR, MLP-LM, and RBF models developed in this study are 4.95%, 5.45%, 6.56%, 7.89%, and 10.9%, respectively. Then, the effect of input parameters on the viscosity of the condensate was determined by the relevancy factor using the results of the Ensemble methods. The most negative and positive effects of parameters on the gas condensate viscosity were related to the reservoir temperature and the mole fraction of C11, respectively. Finally, suspicious laboratory data were determined and reported using the leverage technique.
Association between inter-arm blood pressure difference and cardiovascular disease: result from baseline Fasa Adults Cohort Study
Authors: Sharafi Mehdi , Amiri Zahra , Haghjoo Elham , Afrashteh Sima , Dastmanesh Siavash , Moghaddam Maryam Talebi , Dehghan Azizallah , Tabibzadeh Helma Al-Sadat , Mouseli Ali 
Published: June 2023

AbstractThe inter-arm blood pressure difference has been advocated to be associated with cardiovascular mortality and morbidity. Our study aimed to investigate the association between Inter-arm systolic and diastolic blood pressure differences and Cardio Vascular Disease (CVD). A total of 10,126 participants aged 35–70 years old were enrolled in a prospective Fasa Persian Adult Cohort. In this cross-sectional study, the cutoff values for inter-arm blood pressure difference were less than 5, greater than 5, greater than 10, and greater than 15 mm Hg. Descriptive statistics and logistic regression were used to analyze the data. Based on the results the prevalence of ≥ 15 mmHg inter-arm systolic and diastole blood pressure difference (inter-arm SBPD and inter-arm DBPD) were 8.08% and 2.61%. The results of logistic regression analysis showed that inter-arm SBPD ≥ 15 and (OR<5/≥15 = 1.412; 95%CI = 1.099–1.814) and inter-arm DBPD ≥ 10 (OR<5/≥10 = 1.518; 95%CI = 1.238–1.862) affected the risk of CVD. The results showed that the differences in BP between the arms had a strong positive relationship with CVD. Therefore, inter-arm blood pressure could be considered a marker for the prevention and diagnosis of CVD for physicians.
High endemicity of Opisthorchis viverrini infection among people in northern Cambodia confirmed by adult worm expulsion
Authors: Jung Bong-Kwang , Hong Sooji , Chang Taehee , Cho Jaeeun , Ryoo Seungwan , Lee Keon Hoon , Lee Jeonggyu , Sohn Woon-Mok , Hong Sung-Jong , Khieu Virak , Huy Rekol , Chai Jong-Yil 
Published: June 2023

AbstractOpisthorchis viverrini infection is an emerging disease in Cambodia, especially in central and southeastern areas. However, its status in northern areas bordering Lao PDR has been relatively unknown. The present study was performed to investigate the status of O. viverrini infection among people in Preah Vihear and Stung Treng provinces through fecal examination to detect eggs and recovery of adult flukes from some of the egg-positive cases. Fecal examinations were performed on a total of 1101 people from 10 villages in the 2 provinces using the Kato-Katz thick smear technique. For recovery of adult flukes and other helminth parasites 10 volunteers positive for eggs of Opisthorchis viverrini and/or minute intestinal flukes (Ov/MIF), in Kampong Sangkae village, Preah Vihear province, were administered a single oral dose of 40 mg/kg praziquantel plus 5–10 mg/kg of pyrantel pamoate and purged with 40–50 g magnesium salts. Adult trematodes, together with nematodes and cestodes expelled in diarrheic stools were collected under a stereomicroscope or with the naked eye. The proportion of egg-positive cases for overall liver and intestinal helminths was high but not notably different between the 2 provinces, 65.5% in Preah Vihear versus 64.7% in Stung Treng. The average proportion of Ov/MIF egg-positive cases was 59.8%. A total of 315 adult specimens of O. viverrini were recovered from the 10 volunteers (4–98 specimens per individual; mean, 32). A smaller number of Haplorchis taichui adults, an intestinal fluke, were found mixed-infected in 7 (103 specimens in total; 1–31 per individual; mean, 15) of the 10 volunteers. Adult specimens of hookworms, Enterobius vermicularis, Trichostrongylus sp., and a Taenia tapeworm strobila were recovered in some cases. Based on the results, it has been confirmed that the surveyed areas in Preah Vihear and Stung Treng provinces, Cambodia, are highly endemic areas of O. viverrini infection with a low-grade mixed infection with H. taichui.
Network analysis of pig movement data as an epidemiological tool: an Austrian case study
Authors: Puspitarani Gavrila A. , Fuchs Reinhard , Fuchs Klemens , Ladinig Andrea , Desvars-Larrive Amélie 
Published: June 2023

AbstractAnimal movements represent a major risk for the spread of infectious diseases in the domestic swine population. In this study, we adopted methods from social network analysis to explore pig trades in Austria. We used a dataset of daily records of swine movements covering the period 2015–2021. We analyzed the topology of the network and its structural changes over time, including seasonal and long-term variations in the pig production activities. Finally, we studied the temporal dynamics of the network community structure. Our findings show that the Austrian pig production was dominated by small-sized farms while spatial farm density was heterogeneous. The network exhibited a scale-free topology but was very sparse, suggesting a moderate impact of infectious disease outbreaks. However, two regions (Upper Austria and Styria) may present a higher structural vulnerability. The network also showed very high assortativity between holdings from the same federal state. Dynamic community detection revealed a stable behavior of the clusters. Yet trade communities did not correspond to sub-national administrative divisions and may be an alternative zoning approach to managing infectious diseases. Knowledge about the topology, contact patterns, and temporal dynamics of the pig trade network can support optimized risk-based disease control and surveillance strategies.
Poor glycemic control and associated factors among patients with type 2 diabetes mellitus: a cross-sectional study
Authors: Yahaya James J. , Doya Irene F. , Morgan Emmanuel D. , Ngaiza Advera I. , Bintabara Deogratius 
Published: June 2023

AbstractGlycemic control is of paramount importance in care and management for patients with type 2 diabetes mellitus (T2DM). Poor glycemic control is a major health problem that greatly contributes to the development of diabetes related complications. This study aims to assess the prevalence of poor glycemic control and associated factors among outpatients with T2DM attending diabetes clinic at Amana Regional Referral Hospital in Dar-es-salaam, Tanzania from December 2021 to September 2022. A face to face interviewer semi-structured questionnaire was administered during data collection. Binary logistic regression under multivariable analysis was used to determine the independent predictors of poor glycemic control. A total of 248 patients with T2DM were included in the analysis with mean age of 59.8 ± 12.1 years. The mean fasting blood glucose was 166.9 ± 60.8 mg/dL. The prevalence of poor glycemic control was 66.1% (fasting blood glucose > 130 mg/dL or < 70 mg/dL). Failure to adhere to regular follow-up (AOR = 7.53, 95% CI = 2.34–19.73, p < 0.001) and alcoholism (AOR = 4.71, 95% CI = 1.08–20.59, p = 0.040) were the independent predictors of poor glycemic control. The prevalence of poor glycemic control observed in this study was significantly high. Emphasis should be placed on ensuring that patients have regular follow-up for their diabetes clinics and they should also continue modifying some of lifestyle behaviors including refraining from alcoholism, this can help them to have good glycemic control.
Variable food alters responses of larval crown-of-thorns starfish to ocean warming but not acidification
Authors: Mos Benjamin , Mesic Naomi , Dworjanyn Symon A. 
Published: June 2023

AbstractPhytoplankton abundance is decreasing and becoming more variable as the ocean climate changes. We examine how low, high, and variable phytoplankton food supply affected the survival, development, and growth of larval crown-of-thorns starfish,Acanthastersp. exposed to combined warming (26, 30 °C) and acidification (pH 8.0, 7.6). Larvae fed a low food ration are smaller, and develop slower and with more abnormalities than larvae fed a high ration. Larvae fed a variable food supply (low, followed by high ration) overcome the negative effects of low food on development rate and occurrence of abnormalities, but are 16–17% smaller than larvae fed the high ration continuously. Acidification (pH 7.6) slows growth and development and increases abnormalities regardless of the food regime. Warming slows growth and development, but these effects are mitigated by high food availability. As tropical oceans warm, the success of crown-of-thorns starfish larvae may depend on the abundance of their phytoplankton prey.
Continuous heralding control of vortex beams using quantum metasurface
Authors: Liang Hong , Ahmed Hammad , Tam Wing Yim , Chen Xianzhong , Li Jensen 
Published: June 2023

AbstractMetasurfaces utilize engineered nanostructures to achieve control on all possible dimensions of light, encouraging versatile applications, including beam steering, multifunctional lensing, and multiplexed holograms. Towards the quantum optical regime for metasurfaces, although significant efforts have been put into generating and analyzing specific quantum states, control schemes to further manipulate these quantum states or information are still limited. Here, based on a metasurface, we propose and experimentally demonstrate a continuous heralding scheme to remotely control a vortex beam with high robustness to noise using polarization-entangled photon pairs. Our metasurface entangles polarization and orbital angular momentum (OAM) and the polarization selection on heralding photon erases the which-OAM information on signal photon. It induces an interference of two different OAM states remotely, manifesting a continuous orbital rotation. Our results show that metasurfaces have potential applications in quantum communication and information processing in entangling information with increasing complexity in the content.
An efficient photocatalysis-self-Fenton system based on Fe(ii)-MOF/g-C3N4for direct hydroxylation of benzene to phenol
Authors: Jia Xu , Xu Xuetong , Liu Cong , Wang Fuying , Zhang Liuxue , Jiao Shuyan , Zhu Genxing , Yu Guomin , Wang Xiulian 
Published: June 2023

With the synergistic effect of photocatalysis and the Fenton effect, the Fe(ii)-MOF/g-C3N4 could achieve efficient direct hydroxylation of benzene to phenol.
Cancer and sepsis
Authors: Williams Jeroson C. , Ford Mandy L. , Coopersmith Craig M. 
Published: June 2023

Abstract
Sepsis is one of the leading causes of death worldwide. While mortality is high regardless of inciting infection or comorbidities, mortality in patients with cancer and sepsis is significantly higher than mortality in patients with sepsis without cancer. Cancer patients are also significantly more likely to develop sepsis than the general population. The mechanisms underlying increased mortality in cancer and sepsis patients are multifactorial. Cancer treatment alters the host immune response and can increase susceptibility to infection. Preclinical data also suggests that cancer, in and of itself, increases mortality from sepsis with dysregulation of the adaptive immune system playing a key role. Further, preclinical data demonstrate that sepsis can alter subsequent tumor growth while tumoral immunity impacts survival from sepsis. Checkpoint inhibition is a well-accepted treatment for many types of cancer, and there is increasing evidence suggesting this may be a useful strategy in sepsis as well. However, preclinical studies of checkpoint inhibition in cancer and sepsis demonstrate results that could not have been predicted by examining either variable in isolation. As sepsis management transitions from a ‘one size fits all’ model to a more individualized approach, understanding the mechanistic impact of cancer on outcomes from sepsis represents an important strategy towards delivering on the promise of precision medicine in the intensive care unit.
Diverse mycotoxin threats to safe food and feed cereals
Authors: Latham Rosie L. , Boyle Jeremy T. , Barbano Anna , Loveman William G. , Brown Neil A. 
Published: June 2023

Abstract
Toxigenic fungi, including Aspergillus and Fusarium species, contaminate our major cereal crops with an array of harmful mycotoxins, which threaten the health of humans and farmed animals. Despite our best efforts to prevent crop diseases, or postharvest spoilage, our cereals are consistently contaminated with aflatoxins and deoxynivalenol, and while established monitoring systems effectively prevent acute exposure, Aspergillus and Fusarium mycotoxins still threaten our food security. This is through the understudied impacts of: (i) our chronic exposure to these mycotoxins, (ii) the underestimated dietary intake of masked mycotoxins, and (iii) the synergistic threat of cocontaminations by multiple mycotoxins. Mycotoxins also have profound economic consequences for cereal and farmed-animal producers, plus their associated food and feed industries, which results in higher food prices for consumers. Climate change and altering agronomic practices are predicted to exacerbate the extent and intensity of mycotoxin contaminations of cereals. Collectively, this review of the diverse threats from Aspergillus and Fusarium mycotoxins highlights the need for renewed and concerted efforts to understand, and mitigate, the increased risks they pose to our food and feed cereals.
Tumour-associated macrophages as a potential target to improve natural killer cell-based immunotherapies
Authors: Kitamura Takanori 
Published: June 2023

Abstract
Adoptive transfer of natural killer (NK) cells has been proposed as a novel immunotherapy for malignant tumours resistant to current therapeutic modalities. Several clinical studies have demonstrated that the NK cell-infusion is well tolerated without severe side effects and shows promising results in haematological malignancies. However, patients with malignant solid tumours do not show significant responses to this therapy. Such disappointing results largely arise from the inefficient delivery of infused NK cells and the impairment of their functions in the tumour microenvironment (TME). Tumour-associated macrophages (TAMs) are the most abundant stromal cells in the TME of most solid tumours, and a high TAM density correlates with poor prognosis of cancer patients. Although our knowledge of the interactions between TAMs and NK cells is limited, many studies have indicated that TAMs suppress NK cell cytotoxicity against cancer cells. Therefore, blockade of TAM functions can be an attractive strategy to improve NK cell-based immunotherapies. On the other hand, macrophages are reported to activate NK cells under certain circumstances.
This essay presents our current knowledge about mechanisms by which macrophages regulate NK cell functions and discusses possible therapeutic approaches to block macrophage-mediated NK cell suppression.
Three‐state pattern reconfigurable active antenna integrated with Gunn oscillator and switched‐line phase shifter
Authors: Hasan Maodudul , Nishiyama Eisuke , Tanaka Takayuki , Toyoda Ichihiko 
Published: June 2023

AbstractIn this paper, a novel active integrated array antenna (AIAA) is introduced for the purpose of enabling pattern switchable functionality. The AIAA includes a Gunn oscillator, four microstrip antennas, and two switched‐line phase shifters. The Gunn oscillator provides high‐output RF power to excite the antenna elements through the switched‐line phase shifters. The switched‐line phase shifter allows for switching the main beam direction of the radiation pattern among three states, specifically , and in the ‐plane without shifting its high resonance frequency. Besides, the AIAA requires fewer RF switching diodes in a compact, cheap, and simple layout when compared to previously reported AIAAs. An experimental evaluation of the proposed antenna's performance is conducted and the results indicate an effective isotropic radiated power (EIRP) of +16.09 dBm at the frequency of 9.41 GHz. In all three states, the cross‐polarization suppression is better than 15 dB.