bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical association between intraoperative indocyanine green fluorescence imaging pattern, preoperative Gd‐EOB‐DTPA‐enhanced magnetic resonance imaging findings, and histological differentiation in hepatocellular carcinoma
Authors: Tomino Takahiro , Itoh Shinji , Fujita Nobuhiro , Okamoto Daisuke , Nakayama Yuki , Toshida Katsuya , Tomiyama Takahiro , Tsutsui Yuriko , Kosai Yukiko , Kurihara Takeshi , Nagao Yoshihiro , Morita Kazutoyo , Harada Noboru , Ushijima Yasuhiro , Kohashi Kenichi , Ishigami Kousei , Oda Yoshinao , Yoshizumi Tomoharu 
Published: March 2023

AbstractAimWe aimed to evaluate the association between the intraoperative indocyanine green (ICG) fluorescence imaging (FI) pattern, preoperative magnetic resonance imaging (MRI) findings using gadolinium ethoxybenzyl diethylenetriaminepentaacetic acid (Gd‐EOB‐DTPA), preoperative diffusion‐weighted imaging (DWI) of MRI, and histological differentiation of hepatocellular carcinoma (HCC).MethodsWe retrospectively reviewed the data for 80 tumors of 64 patients. Intraoperative ICG FI patterns were classified into cancerous or rim‐positive type. We evaluated the signal intensity ratio of the tumor and the surrounding liver tissue in the portal phase (SIRPP) and intensity in the hepatobiliary phase (HBP) of Gd‐EOB‐DTPA‐enhanced MRI, the apparent diffusion coefficient (ADC) in the DWI of MRI, and clinicopathologic factors.ResultsIn the rim‐positive group, the rate of poorly differentiated HCC and hypointensity type in HBP were significantly higher, and SIRPP and ADC were significantly lower than the rim‐negative group. In the cancerous group, the rate of well or moderately differentiated HCC and hyperintensity type in HBP, SIRPP, and ADC were significantly higher than the noncancerous group. Multivariate analysis identified low SIRPP, low ADC, and hypointensity type in HBP as the significant predictive factors for rim‐positive HCC and high SIRPP, high ADC, and hyperintensity type in HBP as the significant predictive factors for cancerous HCC. The positive rate of programmed cell death 1‐ligand 1 and vessels that encapsulate tumor clusters status of the rim‐positive HCC and HCC with low SIRPP were significantly higher than the control group.ConclusionsThe intraoperative ICG FI pattern of HCC closely correlated with histological differentiation, preoperative SIRPP and intensity type in the Gd‐EOB‐DTPA MRI, and preoperative ADC in the DWI of MRI.
Controlling hydration of hydratable alumina via co‐grinding with Mg–Al hydrotalcite
Authors: Chen Liugang , Guo Liu , Zhang Hongrui , Li Ye 
Published: March 2023

AbstractThe on‐site industrial application of hydratable alumina (HA)‐bonded castables is inhibited by the high hydration rate of HA. In this study, the hydration behavior of HA co‐ground with sheetlike Mg–Al hydrotalcite (MAT) is investigated. The properties of castables bonded with MAT‐bearing HA are systematically assessed. The hydration rate of HA co‐ground MAT decreases as this allows MAT sheets to be effectively inserted into the microcracks of HA particles during grinding, thus decreasing the direct contact area between HA and water. The strength of MAT‐bearing castables (0.5 and 1 wt%) fired at 800°C improved slightly owning to the generation of magnesia–alumina spinel. The mechanical strength of castables fired at 1100 and 1550°C decreased as the MAT content increased owing to an increase in porosity. Based on an analysis of the hydration behavior of HA and the properties of HA‐bonded castables, the optimal MAT/HA weight ratio is approximately 1/10.
Awareness level regarding adverse reactions caused by cosmetic products among female patients: A cross‐sectional study
Authors: Nayak Manjula , Ligade Virendra S. , Prabhu Smitha S 
Published: March 2023

AbstractBackgroundCosmetics have become an integral part of our daily routine. In addition to causing a wide range of dermatological disorders, cosmetic preparations can also affect internal health. Men are less likely to be impacted than women.ObjectiveThis study aimed at determining the awareness level among female patients regarding adverse reactions caused by cosmetic products.MethodA cross‐sectional study was performed among women who visited the Dermatology department of Kasturba Hospital, Manipal, Karnataka, from December 2020 to March 2022. The sample size included 400 respondents selected using the Convenience sampling method, and data were collected using a self‐administered questionnaire. Data were analyzed using Statistical Package for Social Sciences (SPSS) version 21, and descriptive statistics were applied.ResultsThe study found that many cosmetic users experienced negative side effects (44%). The primarily affected body site was the face (25.50%) followed by scalp and hair (10%). Products responsible for adverse events were skin care products (27.25%). Considerable percentage of patients self‐medicated (22.25%) and only 15% of women consulted a dermatologist for cosmetic‐related problems.ConclusionAwareness regarding the possibility of cosmetic‐induced adverse effects as well as the proper use of cosmetics to reduce these adverse effects is imperative. Implementation of cosmetovigilance system will help to decrease the adverse events to a certain extent.
Maize PIMT2 repairs damaged 3‐METHYLCROTONYL COA CARBOXYLASE in mitochondria, affecting seed vigor
Authors: Zhang Yumin , Song Xianbo , Zhang Wenli , Liu Feijun , Wang Chunmei , Liu Ying , Dirk Lynnette M. A. , Downie A. Bruce , Zhao Tianyong 
Published: March 2023

SUMMARYPROTEIN l‐ISOASPARTYL O‐METHYLTRANSFERASE (PIMT) affects seed vigor by repairing damaged proteins. While PIMT is capable of isoaspartyl (isoAsp) repair in all proteins, those proteins most susceptible to isoAsp formation have not been well characterized, and the mechanisms by which PIMT affects seed vigor remain largely unknown. Using co‐immunoprecipitation and LC‐MS/MS, we found that maize (Zea mays) PIMT2 (ZmPIMT2) interacted predominantly with both subunits of maize 3‐METHYLCROTONYL COA CARBOXYLASE (ZmMCC). ZmPIMT2 is specifically expressed in the maize embryo. Both mRNA and protein levels of ZmPIMT2 increased during seed maturation and declined during imbibition. Maize seed vigor was decreased in the zmpimt2 mutant line, while overexpression of ZmPIMT2 in maize and Arabidopsis thaliana increased seed vigor upon artificial aging. ZmPIMT2 was localized in the mitochondria, as determined by subcellular localization assays using maize protoplasts. ZmPIMT2 binding to ZmMCCα was confirmed by luciferase complementation tests in both tobacco (Nicotiana benthamiana) leaves and maize protoplasts. Knockdown of ZmMCCα decreased maize seed aging tolerance. Furthermore, overexpression of ZmPIMT2 decreased the accumulation of isoAsp of ZmMCCα protein in seed embryos that underwent accelerated aging treatment. Taken together, our results demonstrate that ZmPIMT2 binds ZmMCCα in mitochondria, repairs isoAsp damage, and positively affects maize seed vigor.
Undercarboxylated osteocalcin and ibandronate combination ameliorates hindlimb immobilization‐induced muscle wasting
Authors: Lin Xuzhu , Smith Cassandra , Moreno‐Asso Alba , Zarekookandeh Navabeh , Brennan‐Speranza Tara C. , Duque Gustavo , Hayes Alan , Levinger Itamar 
Published: March 2023

AbstractImmobilization leads to muscle wasting and insulin resistance, particularly during ageing. It has been suggested that undercarboxylated osteocalcin (ucOC) improves muscle mass and glucose metabolism. Bisphosphonates, an anti‐osteoporosis treatment, might protect muscle wasting independent of ucOC. We hypothesize that the combination of ucOC and ibandronate (IBN) treatments has superior protective effects against immobilization‐induced muscle wasting and insulin resistance than either treatment alone. C57BL/6J mice were hindlimb‐immobilized for two weeks, with injections of vehicle, ucOC (90 ng/g daily) and/or IBN (2 μg/g weekly). Insulin/oral glucose tolerance tests (ITT/OGTT) were performed. Immediately after immobilization, muscles (extensor digitorum longus (EDL), soleus, tibialis anterior, gastrocnemius and quadriceps) were isolated and measured for muscle mass. Insulin‐stimulated glucose uptake (EDL and soleus) was examined. Phosphorylation/expression of proteins in anabolic/catabolic pathways were examined in quadriceps. Primary human myotubes derived from older adult muscle biopsies were treated with ucOC and/or IBN, then signalling proteins were analysed. Combined treatment, but not individual treatments, significantly increased the muscle weight/body weight ratio in immobilized soleus (31.7%; P = 0.013) and quadriceps (20.0%; P = 0.0008) muscles, concomitant with elevated p‐Akt (S473)/Akt ratio (P = 0.0047). Combined treatment also enhanced whole‐body glucose tolerance (16.6%; P = 0.0011). In human myotubes, combined treatment stimulated greater activation of ERK1/2 (P = 0.0067 and 0.0072) and mTOR (P = 0.036), and led to a lesser expression of Fbx32 (P = 0.049) and MuRF1 (P = 0.048) than individual treatments. These findings suggest a potential therapeutic role for the ucOC and bisphosphonates combination in protecting against muscle wasting induced by immobilization and ageing.
imageKey points
It has been suggested that undercarboxylated osteocalcin (ucOC) improves muscle mass and glucose metabolism.
Bisphosphonates, an anti‐osteoporosis treatment, might protect against muscle wasting independent of ucOC.
The combination treatment of ucOC and ibandronate was shown to exert a greater therapeutic effect against immobilization‐induced muscle wasting, and led to greater activation of anabolic pathway and less expression of catabolic signalling proteins in myotubes derived from older adults, compared with individual treatments.
The combination treatment was found to improve whole‐body glucose tolerance.
Our findings suggest a potential therapeutic role for the ucOC and bisphosphonates combination in protecting against muscle wasting induced by immobilization and ageing.
Factors related to adverse long-term outcomes after mild traumatic brain injury in children: a scoping review
Authors: Ijaz Sharea , Scott Lauren , Dawson Sarah , Wilson Rebecca , Jackson Joni , Birnie Kate , Redaniel Maria Theresa , Savović Jelena , Wright Ingram , Lyttle Mark D , Mytton Julie 
Published: March 2023

ObjectiveTo identify demographic, premorbid and injury-related factors, or biomarkers associated with long-term (≥3 months) adverse outcomes in children after mild traumatic brain injury (mTBI).DesignScoping review of literature.PatientsChildren and adolescents with mTBI.Risk factorsAny demographic, premorbid and injury-related factors, or biomarkers were included. We excluded genetic and treatment-related factors.Main outcome measuresPostconcussion syndrome (PCS), recovery.ResultsSeventy-three publications were included, reporting 12 long-term adverse outcomes, including PCS in 12 studies and recovery in 29 studies. Additional outcomes studied were symptom scores/severity (n=22), quality of life (n=9) and cognitive function (n=9). Forty-nine risk factors were identified across studies. Risk factors most often assessed were sex (n=28), followed by age (n=23), injury mechanism = (n=22) and prior mTBI (n=18). The influence of these and other risk factors on outcomes of mTBI were inconsistent across the reviewed literature.ConclusionsThe most researched risk factors are sex, age and mechanism of injury, but their effects have been estimated inconsistently and did not show a clear pattern. The most studied outcomes are recovery patterns and symptom severity. However, these may not be the most important outcomes for clinicians and patients. Future primary studies in this area should focus on patient-important outcomes. Population-based prospective studies are needed that address prespecified hypotheses on the relationship of risk factors with given outcomes to enable reliable prediction of long-term adverse outcomes for childhood mTBI.
Identification of PsA phenotypes with machine learning analytics using data from two phase III clinical trials of guselkumab in a bio-naïve population of patients with PsA
Authors: Richette Pascal , Vis Marijn , Ohrndorf Sarah , Tillett William , Ramírez Julio , Neuhold Marlies , van Speybroeck Michel , Theander Elke , Noel Wim , Zimmermann Miriam , Shawi May , Kollmeier Alexa , Zabotti Alen 
Published: March 2023

ObjectivesPsoriatic arthritis (PsA) phenotypes are typically defined by their clinical components, which may not reflect patients’ overlapping symptoms. This post hoc analysis aimed to identify hypothesis-free PsA phenotype clusters using machine learning to analyse data from the phase III DISCOVER-1/DISCOVER-2 clinical trials.MethodsPooled data from bio-naïve patients with active PsA receiving guselkumab 100 mg every 8/4 weeks were retrospectively analysed. Non-negative matrix factorisation was applied as an unsupervised machine learning technique to identify PsA phenotype clusters; baseline patient characteristics and clinical observations were input features. Minimal disease activity (MDA), disease activity index for psoriatic arthritis (DAPSA) low disease activity (LDA) and DAPSA remission at weeks 24 and 52 were evaluated.ResultsEight clusters (n=661) were identified: cluster 1 (feet dominant), cluster 2 (male, overweight, psoriasis dominant), cluster 3 (hand dominant), cluster 4 (dactylitis dominant), cluster 5 (enthesitis, large joints), cluster 6 (enthesitis, small joints), cluster 7 (axial dominant) and cluster 8 (female, obese, large joints). At week 24, MDA response was highest in cluster 2 and lowest in clusters 3, 5 and 6; at week 52, it was highest in cluster 2 and lowest in cluster 5. At weeks 24 and 52, DAPSA LDA and remission were highest in cluster 2 and lowest in clusters 4 and 6, respectively. All clusters improved with guselkumab treatment over 52 weeks.ConclusionsUnsupervised machine learning identified eight PsA phenotype clusters with significant differences in demographics, clinical features and treatment responses. In the future, such data could help support individualised treatment decisions.
Supplementary Figures 1 - 9, Tables 1 - 6 from Identification of Prognostic Groups in High-Grade Serous Ovarian Cancer Treated with Platinum–Taxane Chemotherapy
Authors: Chen Ping , Huhtinen Kaisa , Kaipio Katja , Mikkonen Piia , Aittomäki Viljami , Lindell Rony , Hynninen Johanna , Auranen Annika , Grénman Seija , Lehtonen Rainer , Carpén Olli , Hautaniemi Sampsa 
Published: March 2023

<p>Supplementary Figure S1. Outcome of PSFinder. Supplementary Figure S2. Kaplan-Meier survival curves. Supplementary Figure S3. Kaplan-Meier survival curves on time to progression in month. Supplementary Figure S4. Expression boxplot of validated transcript markers. Supplementary Figure S5. Promoter methylation changes. Supplementary Figure S6. Expression of genes affected by promoter hyper- and hypo- methylation. Supplementary Figure S7. DNMT3B expression. Supplementary Figure S8. Decitabine treatment result. Supplementary Figure S9. Kaplan-Meier survival curves on overall survival time. Tables Supplementary Table S1. PSFinder identified 61 transcripts at isoform-level for Poor I, Poor II and Good prognostic patient characterization. Supplementary Table S2. PSFinder identified 32 genes at gene-level for Poor I, Poor II and Good prognostic patient characterization. Supplementary Table S3. CpG loci with promoter hypermethylation (N=32) and hypomethylation (N=1) in Poor I patients. Supplementary Table S4. Primers and probes used in Taqman qRT-PCR. Supplementary Table S5. PSFinder identified subgroups and BRCA1/2 mutation status in patients from the TCGA discovery set. Supplementary Table S6. LPS predicted subgroups and BRCA1/2 mutation status in patients from the TCGA validation set.</p>
Agentes e procedimentos anestésicos no tratamento das dores de origem muscular
Authors: Cavalcante Valberto de Oliveira , Rocha Roberto de Oliveira , Teixeira Manoel Jacobsen , Gonçalves Raquel Cunha 
Published: March 2023

A infiltração dos pontos gatilho nas síndromes dolorosas miofasciais com anestésicos locais ou com toxina botulínica éeficaz no tratamento de várias afecções álgicas músculo-esqueléticas. Os bloqueios anestésicos da cadeia simpática são eficazes no tratamento e no preparo para o tratamento de doentes que apresentam síndrome complexa de dor regional. O implante de catéteres nos plexos nervosos, ao longo dos troncos nervosos e ou no compartimento espinal para analgesia prolongada é procedimento útil em doentes que aguardam condutas terapêuticas definitivas ou durante a execução de procedimentos de reabilitação que potencialmente agravam condições álgicas pré-existentes. As complicações decorrentes dos procedimentos anestésicos são relacionadas especialmente com a técnica empregada e natureza ou quantidade dos agentes utilizados; na maioria das vezes são passíveis de prevenção e de tratamento satisfatório. Os autores descrevem aspectos históricos, aspectos farmacocinéticos dos agentes e procedimentosanestésicos no tratamento da dor músculo-esquelética.
Dor músculo-esquelética do segmento cefálico
Authors: Siqueira José Tadeu Tesseroli de , Teixeira Manoel Jacobsen Teixeira*, Clement Haman Jacobsen 
Published: March 2023

As disfunções têmporo-mandibulares, são uma das mais importantes razões músculo-esquelética de dor crânio-facial.Devido à complexidade do aparelho mastigatório, à rica inervação das estruturas que o compõem e à sua marcante participação na vida de relação dos indivíduos, anormalidades funcionais ou estruturais que o acometem podem primária ou secundariamente acarretar dor, freqüentemente, incapacitante. O histórico detalhado, os dados de semiologia clínica são mais importantes que os exames complementares para o diagnóstico. O tratamento das afecções músculo-esqueléticas dolorosas fundamenta-se na remoçãodos fatores causais, no controle sintomático da dor e nos procedimentos de reabilitação física e mental. Quando adequadamente aplicados, tais intervenções resultam em melhora da maioria dos doentes.
Lombalgia
Authors: Imamura Satiko Tomikawa , Kaziyama Helena Hideko Seguchi , Imamura Marta 
Published: March 2023

A lombalgia é uma das queixas mais comuns no ser humano. Várias são as razões de sua ocorrência. Dentre elas destacam-se as de origem músculo-esquelética, incluindo especialmente, as síndromes dolorosas miofasciais. Os dados de história e de exame físico são a base do diagnóstico das etiologias e nosologias das lombalgias. A investigação diagnóstica com exames laboratoriais, eletrofisiológicos e de imagens deve ter seus achados validados com base no exame clínico e na história. O tratamento é fundamentado no controle dos sintomas e de suas repercussões físicas e psicossociais e na restauração da funcionalidade das estruturas regionais.
Tratamento cirúrgico funcional da dor
Authors: Teixeira Manoel Jacobsen , Teixeira William Gemio Jacobsen , Fonoff Erich Talamoni 
Published: March 2023

Vários são os procedimentos cirúrgicos funcionais destinados ao tratamento da dor resultante de afecções músculo-esqueléticas. A descompressão de estruturas nervosastronculares ou radiculares angustiadas em decorrência de afecções inflamatórias, degenerativas, oncológicas, deformidades ósseas ou fraturas ou oncológicas do aparelholocomotor pode proporcionar alívio da dor mononeuropática. Os procedimentos neurocirúrgicos funcionais ablativos são indicados em casos de dor por nocicepção; sua indicação é restrita em doente que apresentam perspectivas de sobrevida prolongada. A simpatectomia é pouco eficaz em casos de síndrome complexa de dor regional do tipo II; as neurotomias dos ramos recorrentes posteriores das raízes espinais são úteis no tratamento da cervicalgia, dorsalgiae lombalgia de natureza miofascial; a coagulação, por radiofreqüência, dos discos intervertebrais é indicada em doentes que apresentam lombalgia decorrente de discopatias; a lesão do trato de Lissauer é indicada em casos de dor neruropática e de espasticidade; a mesencefalotomia, as talamotomias e a psicocirurgia são indicadas em casos rebeldes aos tratamentos convencionais. As cordotomias, as rizotomias e as mielopatias não são indicadas em doentes com dor músculo-esquelética. Os procedimentos endocrinológicos incluindo a hipofisectomia são úteis no tratamento da dor decorrente de metástases ósseas especialmente do carcinoma de mama, próstata ou endométrio. A estimulação elétrica do sistema nervoso central geralmente não proporcionam alívio nos doente que apresentam dor músculo-esquelética, exceto, em casos de síndrome pós-laminectomia. A infusão de fármacos analgésicos no compartimento espinal ou no compartimento ventricular é eficaz no tratamento da maioria dos casos.
Thomas Hobbes in Racist Context
Authors: Blau Adrian 
Published: March 2023

Abstract
Is it anachronistic to talk about racism in Hobbes? After all, racism is usually seen as biological: the disliked group must have innate characteristics which are inherited biologically. This is mostly said to be a modern idea. Yet biological racism can be found in medieval and early modern times, as with the Spanish doctrine of limpieza de sangre (cleanliness/purity of blood). Racism, including biological racism, was much more common in Hobbes’s England than we might think, including in texts he may have read; the language of race was hardly uncommon either. Moreover, someone can be called a racist whether or not their dislike of a group is based on characteristics of a group that are inherited biologically, I argue. Whether Hobbes was a racist remains open to debate; this paper offers evidence both for and against that proposition. But we should not reject the question of Hobbes’s racism as anachronistic.
Summer Extreme Precipitation in Southern China from the Perspective of Moisture Static Energy
Authors: Yang Mengzhou , Shi Xia , Yuan Chaoxia , Lu Xinyu , Liu Jingchan 
Published: March 2023

Abstract
The extreme precipitation (EP) in the early and late rainy seasons in Southern China is investigated from the perspective of moist static energy (MSE). At the synoptic time scale, the EP is accompanied by the charge–discharge paradigm of the vertically integrated MSE (〈MSE〉); the positive 〈MSE〉 anomaly reaches the peak one day before EP and decreases quickly during the event. The charge–discharge paradigm of 〈MSE〉 is dominated by the horizontal and vertical advection, respectively. However, synoptic systems responsible for the 〈MSE〉 charge in the early and late rainy seasons are different due to the different horizontal distributions of climatological MSE in the lower troposphere caused by the northward migration of solar radiation and the monsoon system. At the interannual time scale, more EP in the early (late) rainy season is associated with the higher seasonal-mean 〈MSE〉 that can be caused by the anomalous anticyclone (cyclone) in the western North Pacific induced by the SST anomalies in the tropical Indian Ocean and central North Pacific (the tropical Pacific). The multimodel ensemble mean of CMIP6 models reproduces well the observed 〈MSE〉–EP relationship in both the historical and Shared Socioeconomic Pathway 5–8.5 (SSP5–8.5) runs. Moreover, the mean state of 〈MSE〉 increases in the SSP5–8.5 compared to historical runs along with more frequent occurrence of EP events. Hence, 〈MSE〉 can serve as a useful metric for studying EP in Southern China at various time scales.