bluuebunny/crossref_metadata_2025_split huggingface dataset:
Content and distribution of mercury in coal and its relation to depositional environment—A case study on coals from the Shanxi Formation in Huainan Coalfield
Authors: Zheng Liugen , Zhang Liqun , Wang Yunlong , Chen Yeyu , Chen Yongchun , An Shikai , Xu Yanfei 
Published: January 2023

Mercury in coals might emit into the environment from coal combination, and finally cause environmental pollution. In this paper, 26 coal samples were selected from No. 1 which is coal in the Shanxi Formation of Zhangji and Xinjier mines in the Huainan coalfield. The mineralogical and geochemical components of coal samples were determined by DMA-80 mercury-measuring instrument, XRF, XRD, ICP-MS, and the relationship between the depositional environment of the coal seam and mercury enrichment was analyzed. The results show that the mercury content of coal in the study area ranged from 0.03 to 0.93 μg/g, with an arithmetic means of 0.21 μg/g, higher than the background values of coal in China and the world. The mercury content of Shanxi Formation coal varied among different mines, the arithmetic mean value of mercury in Zhangji coal mine and Xinjier mine coal is 0.35 μg/g and 0.12 μg/g respectively. Due to the complex depositional environment and depositional facies, the distribution of mercury content in the coal seam is quite different. XRD, Microscopic observation and the ratio of (CaO + MgO + Fe2O3)/(SiO2+ Al2O3) and Al2O3/TiO2 show that the main mineral in the depositional environment of this study area is kaolinite, quartz and pyrite, and the depositional facies are intercontinental and sea-land, so the parent rock type belongs to acid bedrock. The Ni/Co, Sr/Ba, and Sr/Cu ratios were used to indicate a weak oxidation-reduction, Marine salt water, and an arid and hot environment. The vertical distribution of mercury in coal and the characteristics of the depositional environment are combined to show that mercury in coal is easily affected by redox conditions, paleosalinity and paleoclimate in the depositional environment. At the same time, mercury accumulation is more easily in the depositional environment dominated by seawater intrusion than in the terrigenous input.
Petrogenesis and relationship with REE mineralization of the quartz syenite from Chishan and Longbaoshan alkaline complex, southeastern North China Craton: Insights from zircon U–Pb geochronology, element, and Sr–Nd–Pb–Hf isotope geochemistry
Authors: Wei Pengfei , Li Dapeng , Song Zhigang , Liu Qiang , Geng Ke , Zhang Yan , Ding Chengwu , Cai Na , Li Zengsheng , Zhang Chao , Xie Wei 
Published: January 2023

Mesozoic alkaline complexes associated with the rare earth element (REE) mineralization are developed in southeastern North China Craton (NCC), and they recorded some important information about the lithospheric thinning and destruction of the NCC. Zircon U–Pb dating results reveal that syenitic rocks from the Chishan and Longbaoshan alkaline complexes were emplaced at ca. 126.2–123.7 Ma. These syenitic rocks have an arc-like affinity with enriched LREEs and LILEs (e.g., Ba and Th) and depleted HFSE (e.g., Nb and Ta). However, they plot within the extensional alkaline–calc-alkaline field in the lg (CaO/(K2O + Na2O)) versus SiO2 discrimination diagram and plot within the fields of the divergent plate and within-plate settings in the NbN versus ThN discrimination diagram, implying an extensional tectonic setting. Thus, we suggest that the syenitic rocks should form in an extensional tectonic settings related to rollback and retreat of the subducting Paleo-Pacific plate. These syenitic rocks have similar Sr–Nd–Pb–Hf isotope compositions ((87Sr/86Sr)i = 0.7062 to 0.7101, εNd(t) = −8.2 to −15.0, εHf(t) = −13.5 to −9.6), which are the same as the enriched subcontinental lithospheric mantle (SCLM) of the NCC. Taking into account not only our new data but also previously published data regarding the evolution of NCC in the Mesozoic, we conclude that the syenitic rocks from the Chishan and Longbaoshan complexes are derived from partial melting of the lithospheric mantle triggered by the Paleo-Pacific plate subduction. Moreover, the geochemical and Sr–Nd–Pb isotopic similarity between the Chishan REE ores, Longbaoshan altered rocks, and the syenitic rocks implied that they are homologous products of Early Cretaceous and that the mineralization shows inheritance to the magmatic hydrothermal evolution.
Study on the influence of the tectonic evolution of Shuangyashan Basin on gas occurrence and extraction in mines
Authors: Lan Tianwei , Zhang Zhijia , LE QUY BAO , Liu Yonghao , Wang Shunxiang 
Published: January 2023

The formation and later evolution of coal-bearing basins in eastern Heilongjiang are controlled by multi-phase tectonic movements, and the Shuangyashan Basin is tectonically located at the southern end of the Sanjiang Basin in the northeast. The paper focuses on the regional geological and tectonic evolution of the Shuangyashan Basin and its influence on the gas occurrence law and extraction difficulty of the Jixian Coal Mine. The study determined that the gas occurrence of the mine in the Suibin-Jixian depression basin has regional aggregation and caprock sealing characteristics. The gas pressure and content of the 9# Coal Seam were measured in the underground test, and the results showed that the 9# coal seam is a hard-to-extract coal seam with low permeability. Aiming at the issue of hard-to-extract gas in 904 Working Face of 9# Coal Seam which is affected by depression basin and derived secondary tectonic conditions, numerical calculation and analysis of gas extraction effect of working face with different extraction parameters were carried out by COMSOL software, the results showed that: negative extraction pressure has less influence on gas extraction effect under basin conditions; when 113 mm diameter borehole is used for gas extraction, gas pressure decreases to 0.72 MPa; when the spacing of extraction borehole is 2 m, the gas pressure is reduced by 20%; when the coal seam permeability is increased by 10 times to more than 0.015 mD, the gas pressure is reduced by more than 50%. The optimized gas extraction scheme with 113 m diameter, 2 m borehole spacing, and 15 kPa negative pressure was proposed for the test working face, and combined with supercritical CO2 fracturing and permeability enhancement technology. Under underground measurement, the coal seam gas content was reduced by 39.7% compared to the original gas extraction scheme. It can be seen that the reasonable gas extraction scheme and coal seam pressure relief and permeability enhancement technology can significantly improve the gas extraction rate, and the extraction effect is remarkable.
Age-related and individual features of the HPA axis stress responsiveness under constant light in nonhuman primates
Authors: Goncharova Nadezhda , Chigarova Olga , Oganyan Tamara 
Published: January 2023

The hypothalamic-pituitary-adrenal (HPA) axis is a key adaptive neuroendocrine system, dysfunction of which plays an important role in the increasing incidence of stress-dependent age-related pathology. Among the environmental factors effecting increase age-related diseases, great importance is given to disturbances of the light-dark schedule, particularly with increased illumination at night. While disruption of the light-dark schedule has long been recognized as a powerful behavioral stressor, little is known regarding stress reactivity of the HPA under constant light (CL) conditions, especially with aging and depending on the features of stress behavior. The purpose of this investigation was to study the age-related and individual features of the HPA axis response to acute stress exposure (ASE) under chronic CL in nonhuman primates that are known to differ in behavioral responsiveness to stress. Young and old female rhesus monkeys (with control standard behavior or anxiety and depression-like behavior) were exposed to CL (24 h light/day, 330-400 lux for 4 to 8 weeks). Control young and old monkeys were exposed to standard lighting (SL) with natural light during the day and darkness at night. All animals were subjected to ASE (restriction of mobility for 2 hours), functional tests with corticotrophin-releasing hormone and arginine-vasopressin, and study of circadian rhythms of cortisol and pineal melatonin secretion. For the first time an inhibitory effect of CL on the reaction of the adrenal cortex to ASE was revealed in all individuals, regardless of age and preexisting behavior stress reactivity, the mechanisms of which were age-dependent: due to inhibition of the pituitary ACTH secretion in young animals and mainly not affecting the ACTH secretion in old individuals. There were no significant changes in melatonin secretion both in young and old animals. The observed CL inhibition of adrenal cortical reactivity to ASE may be useful to correct increased vulnerability to ASE observed in individuals with preexisting anxiety and depression-like stress behaviors. On the other hand, the CL induced decrease in adrenal stress reactivity of behaviorally normal animals suggests a potential risk of reducing the adaptive capacity of the organism under conditions of continuous light exposure.
Effect of sodium-glucose cotransporter protein-2 inhibitors on left ventricular hypertrophy in patients with type 2 diabetes: A systematic review and meta-analysis
Authors: Wang Yao , Zhong Yujie , Zhang Zhehao , Yang Shuhao , Zhang Qianying , Chu Bingyang , Hu Xulin 
Published: January 2023

ObjectiveThis systematic review and meta-analysis was performed to compare the effect of sodium-glucose cotransporter protein-2 inhibitors (SGLT-2i) and placebo on left ventricular hypertrophy (LVH) in patients with type 2 diabetes.MethodRandomized controlled trials (RCTs) comparing the LVH parameters of SGLT-2i to placebo in patients with type 2 diabetes were included. Our primary outcomes were the changes in left ventricular mass (LVM) and left ventricular mass index (LVMI) from baseline to the study endpoint. Secondary outcomes were the changes in left ventricular end-diastolic volume (LVEDV), left ventricular end-systolic volume (LVESV), left ventricular ejection fraction (LVEF), and the ratio of early mitral inflow velocity to atrial inflow velocity (E/A). Summary odds ratios were estimated using a fixed-effect or random-effect model.ResultsA total of 11 articles were included. Data were extracted from 11 original studies matching our inclusion criteria. In our meta-analysis, there were significant improvement in LVM (SMD −0.23, 95% CI −0.44 to −0.02, I2 = 22.6%, p = 0.034), LVMI (SMD −0.25, 95% CI −0.38 to −0.12, I2 = 0.0%, p = 0.000), LVEDV (SMD −0.19, 95% CI −0.36 to −0.01, I2 = 62.3%, p = 0.035), and LVESV (SMD −0.21, 95% CI −0.39 to −0.04, I2 = 32.9%, p = 0.017) in the SGLT-2i group compared with the placebo group. Furthermore, no significant differences were found in LVEF (SMD 0.13, 95% CI 0.00 to 0.26, I2 = 0.0%, p = 0.050) and E/A (SMD −0.01, 95% CI −0.22 to 0.20, I2 = 0%, p = 0.908) between the two groups.ConclusionsThis meta-analysis confirmed the beneficial effects of SGLT-2i on reversal of left ventricular remodeling. The LVH regression was more pronounced in studies of type 2 diabetes patients receiving SGLT-2i than placebo.
Exploring novel targets of sitagliptin for type 2 diabetes mellitus: Network pharmacology, molecular docking, molecular dynamics simulation, and SPR approaches
Authors: Qi Jian-hong , Chen Pu-yu , Cai Ding-yuan , Wang Yi , Wei Yue-lei , He Su-ping , Zhou Wei 
Published: January 2023

BackgroundDiabetes has become a serious global public health problem. With the increasing prevalence of type 2 diabetes mellitus (T2DM), the incidence of complications of T2DM is also on the rise. Sitagliptin, as a targeted drug of DPP4, has good therapeutic effect for T2DM. It is well known that sitagliptin can specifically inhibit the activity of DPP4 to promote insulin secretion, inhibit islet β cell apoptosis and reduce blood glucose levels, while other pharmacological mechanisms are still unclear, such as improving insulin resistance, anti-inflammatory, anti-oxidative stress, and anti-fibrosis. The aim of this study was to explore novel targets and potential signaling pathways of sitagliptin for T2DM.MethodsFirstly, network pharmacology was applied to find the novel target most closely related to DPP4. Semi-flexible molecular docking was performed to confirm the binding ability between sitagliptin and the novel target, and molecular dynamics simulation (MD) was carried to verify the stability of the complex formed by sitagliptin and the novel target. Furthermore, surface-plasmon resonance (SPR) was used to explored the affinity and kinetic characteristics of sitagliptin with the novel target. Finally, the molecular mechanism of sitagliptin for T2DM was predicted by the enrichment analysis of GO function and KEGG pathway.ResultsIn this study, we found the cell surface receptor―angiotensin-converting enzyme 2 (ACE2) most closely related to DPP4. Then, we confirmed that sitagliptin had strong binding ability with ACE2 from a static perspective, and the stability of sitagliptin―ACE2 complex had better stability and longer binding time than BAR708―ACE2 in simulated aqueous solution within 50 ns. Significantly, we have demonstrated a strong affinity between sitagliptin and ACE2 on SPR biosensor, and their kinetic characteristics were “fast binding/fast dissociation”. The guiding significance of clinical administration: low dose can reach saturation, but repeated administration was needed. Finally, there was certain relationship between COVID-19 and T2DM, and ACE2/Ang-(1-7)/Mas receptor (MasR) axis may be the important pathway of sitagliptin targeting ACE2 for T2DM.ConclusionThis study used different methods to prove that ACE2 may be another novel target of sitagliptin for T2DM, which extended the application of ACE2 in improving diabetes mellitus.
Adaptive robust economic dispatch and real-time control of distribution system considering controllable inverter air-conditioner clusters
Authors: Chen Guanhong , Liu Dong 
Published: January 2023

With a tremendous number of renewable energy sources (RES) integrated into the distribution system, the inherent uncertainty of RES power generation brings about significant challenges in distribution and power balance within the distribution system. This article proposes an adaptive robust economic dispatch (ARED) model and a real-time control strategy for distribution systems as countermeasures, which make full use of the adjustable capabilities of controllable inverter air-conditioner (IAC) clusters. Firstly, the concept of the adjustable capacity curve (ACC) is developed to accurately quantify the adjustable capacity of an IAC cluster. Afterward, a two-stage adaptive robust optimization is formulated for ARED, which comprehensively takes the adjustable capacity of the IAC cluster and the uncertainty of RES into consideration. Meanwhile, the solution methodology of ARED is also designed based on the column and constraint generation (C&amp;CG) algorithm, where the master problem is quadratic programming with quadratic constraints (QCQP), and the max-min sub-problem is reformulated to a mixed integer linear programming (MILP) form by taking advantage of linear duality theory and big-M method. Finally, a novel real-time decentralized control strategy for IAC clusters is also proposed for purpose of hedging against stochastic RES power fluctuation after every round of ARED decisions. The results of the case study validate the effectiveness of ARED model and real-time control strategy under different uncertainty scenarios of RES power generation.
Gabor-YOLONet: A lightweight and efficient detection network for low-voltage power lines from unmanned aerial vehicle images
Authors: Feng Lei , Zhang Lianmei , Gao Zepu , Zhou Ruoyun , Li Lan 
Published: January 2023

Maintaining and monitoring low-voltage overhead power lines are of great importance because such lines are the key link between the power system and low-voltage power users. At present, few networks can be detected accurately on intelligent edge identification devices because of the complex backgrounds and limited characteristics in unmanned aerial vehicle images as well as the low computing abilities of hardware. In order to give consideration to accuracy and speed, a novel power line detection method was proposed, denoted by Gabor-YOLONet, used for intelligent edge identification devices available to UAV. Unlike existing methods, the proposed method uses the Gabor algorithm to extract foreground of power lines from cluttered backgrounds automatically and predict power lines and their auxiliary targets such as insulators in the foreground scene. In addition, a new inference method was introduced, which can summarize the average location and orientation of auxiliary targets by clustering to verify the rationality of the predicted results for power lines. The experiment results showed that the proposed method had the higher accuracy and consumed less computing resources; compared with other methods, the mAP of identification for power lines was 86.6% and the running time was only 25 ms, with excellent performance on intelligent edge devices.
Multi-Objective optimization of an IGV for a large axial fan based on NSGA-II
Authors: Zhou Shuiqing , Zhang Tianle , Mao Zijian , Lu Laifa 
Published: January 2023

Large axial fans are widely used in industrial refrigeration, building ventilation, and other scenarios because they have inlet guide vanes (IGVs) and outlet guide vanes (OGVs) to make their operation economical and efficient. However, unreasonable guide vane structure is prone to flow separation, forming a tail vortex and interfering with other blades, thereby resulting in the deterioration of working conditions and large noise. Taking a large axial fan with both IGVs and OGVs as the research object, this paper analyzed the structural variables of the fan by global sensitivity analysis method and determine the target of settings optimization as IGV according to the analysis results and the internal flow characteristics of the fan. Furthermore, IGV was parametrically designed, and Kriging model was established and optimized by the second non-dominated sorting genetic algorithm (NSGA-II). Eventually, total pressure and sound pressure level (SPL) were used as targets for multi-objective optimization. The results indicated that the noise produced by the optimized fan was reduced by 6.4 dB and total pressure was increased by 156.4 Pa, with an increase of 0.86% in the total pressure efficiency at the rated working condition, which proved the reliability of the proposed method. This paper also provides a valuable reference for the optimization of similar fluid equipment.
Determining urban‒rural coordinated development in major grain-producing areas based on urbanization and cultivated land use efficiency coordination level: A case study in Hunan Province, China
Authors: Wei Xue , Liu Liming , Yuan Chengcheng , Xia Zheyi 
Published: January 2023

Urbanization and cultivated land use coordination is the key to urban‒rural coordinated development, especially in the major grain-producing areas in China, but it is rarely examined. A coordination framework of urbanization and cultivated land use efficiency systematically clarified how to achieve Urbanization and cultivated land use coordination. Taking Hunan Province as an example, this study explored the spatiotemporal evolution of the level of Urbanization and cultivated land use coordination from 2000 to 2018 at the county level, identified current types of Urbanization and cultivated land use coordination and discussed the key optimization measures for different types. The results showed that 1) urban‒rural coordinated development, abstractly represented by the Urbanization and cultivated land use coordination in major grain-producing areas, depends on the intensity of interactions and the level of integration of urbanization and cultivated land use systems. 2) From 2000 to 2018, the level of Urbanization and cultivated land use coordination in Hunan changed from serious maladjustment to great maladjustment to coordination. 3) The current Urbanization and cultivated land use coordination pattern in Hunan Province has a strong spatial differentiation, which can be divided into eight subregions. The key to the coordinated development of each type is to accelerate the flow of elements through deepening reform and innovation mechanisms to complement the shortcomings of development. This study will provide a scientific reference for the effective implementation of regional coordinated development strategies in major food-producing regions.
A novel frameshift mutation in TRPV6 is associated with hereditary pancreatitis
Authors: Shah Idrees A. , Prasad Hari , Banerjee Sanghita , Kurien Reuben Thomas , Chowdhury Sudipta Dhar , Visweswariah Sandhya S. 
Published: January 2023

Introduction: Hereditary pancreatitis (HP) is a rare debilitating disease with incompletely understood etio-pathophysiology. The reduced penetrance of genes such as PRSS1 associated with hereditary pancreatitis indicates a role for novel inherited factors.Methods: We performed whole-exome sequencing of three affected members of an Indian family (Father, Son, and Daughter) with chronic pancreatitis and compared variants with those seen in the unaffected mother.Results: We identified a novel frameshift mutation in exon 11 of TRPV6 (c.1474_1475delGT; p.V492Tfs*136), a calcium channel, in the patients. Functional characterization of this mutant TRPV6 following heterologous expression revealed that it was defective in calcium uptake. Induction of pancreatitis in mice induced Trpv6 expression, indicating that higher expression levels of the mutant protein and consequent dysregulation of calcium levels in patients with chronic pancreatitis could aggravate the disease.Discussion: We report a novel frameshift mutation in TRPV6 in an Indian family with HP that renders the mutant protein inactive. Our results emphasize the need to expand the list of genes used currently for evaluating patients with hereditary pancreatitis.
Low expression of NR1H3 correlates with macrophage infiltration and indicates worse survival in breast cancer
Authors: Zhang Jing , Zhang Jiawen , Zhao Weiwei , Li Qingxian , Cheng Wenwu 
Published: January 2023

Background: Nuclear receptor NR1H3 is a key regulator of macrophage function and lipid homeostasis. Here, we aimed to visualize the prognostic value and immunological characterization of NR1H3 in breast cancer.Methods: The expression pattern and prognostic value of NR1H3 were analyzed via multiple databases, including TIMER2, GEPIA2 and Kaplan-Meier Plotter. TISIDB, TIMER2 and immunohistochemical analysis were used to investigate the correlation between NR1H3 expression and immune infiltration. GO enrichment analysis, KEGG analysis, Reactome analysis, ConsensusPathDB and GeneMANIA were used to visualize the functional enrichment of NR1H3 and signaling pathways related to NR1H3.Results: We demonstrated that the expression of NR1H3 was significantly lower in breast cancer compared with adjacent normal tissues. Kaplan-Meier survival curves showed shorter overall survival in basal breast cancer patients with low NR1H3 expression, and poorer prognosis of relapse-free survival in breast cancer patients with low NR1H3 expression. NR1H3 was mainly expressed in immune cells, and its expression was closely related with infiltrating levels of tumor-infiltrating immune cells in breast cancer. Additionally, univariate and multivariate analysis indicated that the expression of NR1H3 and the level of macrophage infiltration were independent prognostic factors for breast cancer. Gene interaction network analysis showed the function of NR1H3 involved in regulating of innate immune response and macrophage activation. Moreover, NR1H3 may function as a predictor of chemoresponsiveness in breast cancer.Conclusion: These findings suggest that NR1H3 serves as a prognostic biomarker and contributes to the regulation of macrophage activation in breast cancer.