bluuebunny/crossref_metadata_2025_split huggingface dataset:
THE CONTRIBUTION OF THE PROCESSING INDUSTRY TO IMPROVING INDONESIA'S ECONOMY BEFORE AND AFTER THE PANDEMIC
Authors: Chodijah Chodijah 
Published: July 2023

The impact of the covid-19 pandemic has made the economy in Indonesia weakened. we can look at the high levels of unemployment and poverty at that time. The processing industry is one of the sectors that has an important role in driving the economy in Indonesia. This study analyzes the contribution of the processing industry sector in the post-pandemic economic recovery using the Input-Output table analysis method. The Data that the researchers used came from the Central Statistics Agency (BPS). Based on the results of the study, most of the processing industry subsectors have the ability to encourage production growth and improve economic recovery during a pandemic through seven subsectors that have consistently contributed to increasing labor absorption, improving weakening household consumption and weakening people's purchasing power due to the covid 19 pandemic in Indonesia. According to data from the Central Bureau of Statistics (BPS), the food and beverage industry subsector is the largest contributor by generating gross domestic product (GDP) of 1,057,001 27 billion in 2020. Followed by the other six sub-sectors of the processing industry which also contributed a lot to economic recovery. The processing industry is one of the industries that plays an important role in helping the economic recovery of the community in Indonesia after the pandemic.
Bundeskanzlei verhindert freien Zugang und subventioniert NZZ Libro Verlag
Authors: Gutknecht Christian 
Published: July 2023

Die folgende Geschichte fängt mit der Pressemeldung Bundesrat nimmt den Bericht «Die Schweiz 2030» zur Kenntnis vom 16.10.2018 an. Die Schweizerische Bundeskanzlei hat 77 Persönlichkeiten aus verschiedene Branchen und Landesteilen eingeladen, kurz und prägnant wichtige Entwicklungen, die der Bundesrat bei der Festlegung der Bundespolitik berücksichtigen sollte, zu schildern.
Effect of Khat on Blood Coagulation
Authors: Mohammed Amood Al-Kamarany  , Nabil Ahmed Albaser  , Hussein Omar Kadi  , Badiaa  Lyoussi  
Published: July 2023

Catha edulis Forsk leaves " Khat " are chewed daily by a high proportion of the adult population in Yemen .The present study investigated the relationship between blood coagulation and khat chewing .In our study , we investigated the blood coagulation tests in two groups namely khat chewers group (n:30) and non– khat chewers group (n:60). The blood coagulation tests included bleeding time , clotting time , prothrombin time , partial thromboplastin time and platelets count. Statistical testing for data analysis included the student's t-test and chi 2 test. The results presented show the level of bleeding time , clotting time , prothrombin time , platelets count and platelets aggregation to be significantly different between khat chewers and non – khat chewers (p< 0.05) , we observed decrease in bleeding time , clotting time and prothrombin time in khat chewers less than normal values and we also observed enhance in platelets aggregation in khat chewers in comparison with non – khat chewers . The results presented show the level of partial thromboplastin time to be non -significantly different (p > 0.05) between both groups . The study concluded the khat chewing effects on blood coagulation physiology and consider as risk factor for blood coagulation system.
1. Forhandlingsemne
Authors: Gundersen O. C. , Smith Jørgen , Anttila Inkeri , Thornstedt Hans 
Published: July 2023

Side 3-23: Høyesterettsdommer O. C. Gundersen, Oslo.
Side 24-35: Politiadvokat Jørgen Smith, København
Side 36-40: Docent Inkeri Anttila, Finland
Side 41-53: Docent Hans Thornstedt, Stockholm
Percepción de las organizaciones de personas con discapacidad sobre el tratamiento mediático del colectivo en espacios informativos
Authors: Figuereo-Benítez Juan C. , García-Prieto Victoria , Bonilla-del-Río Mónica 
Published: July 2023

El tratamiento que los medios de comunicación dan a las personas con discapacidad es un asunto importante para su movimiento asociativo, que busca la inclusión y participación activa de las personas con discapacidad en todos los ámbitos de la sociedad. Aunque se ha avanzado en el modo en el que los medios informan sobre la discapacidad, persiste la preocupación en el colectivo por el tipo de noticias y los marcos desde los que se abordan. La metodología cualitativa del estudio es la entrevista semiestructurada a federaciones y confederaciones asociadas al Comité Español de Representantes de Personas con Discapacidad (Cermi). Los resultados apuntan a que persisten las perspectivas paternalistas o capacitistas que alejan la imagen mostrada de la realidad del colectivo. Se observan discrepancias entre los casos de las personas ciegas o con síndrome de Down, con una representación más ajustada, y las personas con discapacidad psicosocial, cuyo caso sigue estando estigmatizado. Las organizaciones ponen el foco en la mejora de la formación y la especialización de los profesionales de la información, así como en la colaboración con el colectivo para mejorar el tratamiento mediático. Se puede concluir que el espacio informativo dedicado sigue siendo insuficiente, estereotipado y desigual entre los distintos tipos de discapacidad.
Effect of Different Drying Methods on the Total Phenolic and Flavonoid Content and DPPH Free-Radical Scavenging Activity of Pandanus amaryllifolius Roxb. Planted in Mekong Delta
Authors: Son Hoang Le , Luynh Bui Nguyen Cac , Minh Tran Van 
Published: July 2023

Aims: This study aimed to investigate the total phenolic and flavonoid content and DPPH free-radical scavenging activity of Vernonia amygdalina planted in Mekong Delta. The optimized conditions for maceration of pandan leaves included drying method, ratio of pandan leaf powder-to-solvent, and extraction time.
Methodology: The fresh pandan leaves were divided into two equal portions, subjected to different drying methods: shade and oven drying. The dried leaf powder was macerated in ethanol at room temperature. The maceration was conducted with 3 different ratios of pandan leaf powder-to-solvent (w/v) (1:10, 1:15 and 1:20), and the extraction time was 1, 2 and 3 days. The total flavonoid content was determined using aluminum chloride method whereas the total phenolic content was assessed using Folin-Ciocalteu assay. Meanwhile, the antioxidant activity of the plant extracts was quantitatively evaluated using DPPH test.
Results: The results indicated that the best conditions for maceration of pandan leaves were 1:10 shade-dried leaf powder-to-solvent ratio in 1-day extraction time. Accordingly, the total flavonoid and phenolic content was found to be the highest value of 130.02 ± 2.24 mg QE/g of dried extract and 100.67 ± 1.76 mg GAE/g of dried extract (p < 0.05), respectively. The lowest IC50 of DPPH free-radical scavenging activity of pandan leaf extract was found to be 0.90 ± 0.02 mg/mL (p < 0.05). In addition, the Pearson’s correlation coefficient between IC50 of DPPH free-radical scavenge activity and total flavonoid content was R2 = 0.74 compared to that of phenolic content with the value of R2 = 0.69, indicating that the IC50 of DPPH free-radical scavenge capacity of pandan leaves was influenced chiefly by flavonoid compounds.
Conclusion: There was a significant difference in phenolic and flavonoid content and DPPH free-radical scavenging activity between shade-dried and oven-dried pandan leaf extracts.
Psychosocial factors as predictors of aggressive behaviors among primary school learners
Authors: Osiesi Mensah P. , Sanni Kamorudeen T. , Blignaut Sylvan , Adeniran Sunday A. , Dikko Basirat O. , Fajobi Olutoyin O. , Adekoya Adebolu F. , Udemba Esther C. , Adegboyega Sikeade M. 
Published: July 2023

AbstractThe study investigated psychosocial factors as predictors of aggressive behaviors among primary school learners in Ekiti State, Nigeria. The study used a survey research design. All public primary school learners in Ekiti State formed the target population. A sample size of one thousand three hundred and fifty (1350) respondents was selected using a multistage sampling procedure, consisting of 641 males (47.5%) and 709 females (52.5%), ages 9–13 years, who participated in the study. A self‐report instrument tagged “Learners' Aggressive Behaviours Questionnaire” (α indexes of .81, .70, .77, and .84 for the four components respectively) was used for data collection. The data were analyzed using multiple regression analysis at a 5% level of significance. The empirical findings revealed that parenting styles, peer influence, and self‐control significantly predicted learners' aggressive behavior. Recommendations for curbing aggressive behavior among learners were highlighted.
HLA in isolated REM sleep behavior disorder and Lewy body dementia
Authors: Yu Eric , Krohn Lynne , Ruskey Jennifer A. , Asayesh Farnaz , Spiegelman Dan , Shah Zalak , Chia Ruth , Arnulf Isabelle , Hu Michele T. M. , Montplaisir Jacques Y. , Gagnon Jean‐François , Desautels Alex , Dauvilliers Yves , Gigli Gian Luigi , Valente Mariarosaria , Janes Francesco , Bernardini Andrea , Högl Birgit , Stefani Ambra , Ibrahim Abubaker , Heidbreder Anna , Sonka Karel , Dusek Petr , Kemlink David , Oertel Wolfgang , Janzen Annette , Plazzi Giuseppe , Antelmi Elena , Figorilli Michela , Puligheddu Monica , Mollenhauer Brit , Trenkwalder Claudia , Sixel‐Döring Friederike , Cochen De Cock Valérie , Ferini‐Strambi Luigi , Dijkstra Femke , Viaene Mineke , Abril Beatriz , Boeve Bradley F. , Rouleau Guy A. , Postuma Ronald B. ,   The International LBD Genomics Consortium, Scholz Sonja W. , Gan‐Or Ziv 
Published: July 2023

AbstractSynucleinopathies‐related disorders such as Lewy body dementia (LBD) and isolated/idiopathic REM sleep behavior disorder (iRBD) have been associated with neuroinflammation. In this study, we examined whether the human leukocyte antigen (HLA) locus plays a role in iRBD and LBD. In iRBD, HLA‐DRB1*11:01 was the only allele passing FDR correction (OR = 1.57, 95% CI = 1.27–1.93, p = 2.70e‐05). We also discovered associations between iRBD and HLA‐DRB1 70D (OR = 1.26, 95%CI = 1.12–1.41, p = 8.76e‐05), 70Q (OR = 0.81, 95%CI = 0.72–0.91, p = 3.65e‐04) and 71R (OR = 1.21, 95%CI = 1.08–1.35, p = 1.35e‐03). Position 71 (pomnibus = 0.00102) and 70 (pomnibus = 0.00125) were associated with iRBD. Our results suggest that the HLA locus may have different roles across synucleinopathies.
Reduced Energetic Disorders in Dion–Jacobson Perovskites for Efficient and Spectral Stable Blue LEDs
Authors: Seo Jisung , Wang Kang , Coffey Aidan H. , He Guiying , Yang Hanjun , Lee Yoon Ho , Ma Ke , Sun Jiaonan , Park Jee Yung , Zhao Han , Yuan Chongli , Zhu Chenhui , Sfeir Matthew Y. , Dou Letian 
Published: July 2023

AbstractMetal halide perovskites have witnessed great success in green, red, and near‐infrared light‐emitting diodes (LEDs), yet blue LEDs still lag behind. Reducing undesired energetic disorders – broad n‐phases and halide segregation – is considered as the most critical strategy to further improve the performances. Here, the study reports a newly designed and synthesized di‐ammonium ligand with rigid π‐conjugated rings and additional methyl groups to construct Dion–Jacobson (DJ) structure. Augmented coordination from the extra ammonium site and increased effective bulkiness from methyl groups lead to better distribution control over conventional mono‐ammonium ligands. This enhances the radiative recombination of blue emissions in the film with homogeneous energy landscape and improved surface morphology, as evidenced by a series of imaging and mapping techniques. As a result, it demonstrates DJ perovskite LEDs (PeLEDs) with peak external quantum efficiencies of ≈4% at 484 nm and ≈11% at 494 nm, which are among the top reported for pure DJ phase‐based PeLEDs in the corresponding wavelength regions. The results deepen the understanding of regulating energetic disorders in perovskite materials via molecular engineering.
Yin Yang 1‐Induced Long Noncoding RNA DUXAP9 Drives the Progression of Oral Squamous Cell Carcinoma by Blocking CDK1‐Mediated EZH2 Degradation
Authors: Zhou Wenkai , Feng Yisheng , Lin Chengzhong , CHAO Chi Kuan , He Ziqi , Zhao Shiyao , Xue Jieyuan , Zhao Xu‐Yun , Cao Wei 
Published: July 2023

AbstractLncRNAs play a critical role in oral squamous cell carcinoma (OSCC) progression. However, the function and detailed molecular mechanism of most lncRNAs in OSCC are not fully understood. Here, a novel nuclear‐localized lncRNA, DUXAP9 (DUXAP9), that is highly expressed in OSCC is identified. A high level of DUXAP9 is positively associated with lymph node metastasis, poor pathological differentiation, advanced clinical stage, worse overall survival, and worse disease‐specific survival in OSCC patients. Overexpression of DUXAP9 significantly promotes OSCC cell proliferation, migration, invasion, and xenograft tumor growth and metastasis, and upregulates N‐cadherin, Vimentin, Ki67, PCNA, and EZH2 expression and downregulates E‐cadherin in vitro and in vivo, whereas knockdown of DUXAP9 remarkably suppresses OSCC cell proliferation, migration, invasion, and xenograft tumor growth in vitro and in vivo in an EZH2‐dependent manner. Yin Yang 1 (YY1) is found to activate the transcriptional expression of DUXAP9 in OSCC. Furthermore, DUXAP9 physically interacts with EZH2 and inhibits EZH2 degradation via the suppression of EZH2 phosphorylation, thereby blocking EZH2 translocation from the nucleus to the cytoplasm. Thus, DUXAP9 can serve as a promising target for OSCC therapy.
Wafer‐Level Manufacturing of MEMS H2 Sensing Chips Based on Pd Nanoparticles Modified SnO2 Film Patterns
Authors: Zhang Zheng , Luo Liyang , Zhang Yanlin , Lv Guoliang , Luo Yuanyuan , Duan Guotao 
Published: July 2023

AbstractIn this manuscript, a simple method combining atomic layer deposition and magnetron sputtering is developed to fabricate high‐performance Pd/SnO2 film patterns applied for micro‐electro‐mechanical systems (MEMS) H2 sensing chips. SnO2 film is first accurately deposited in the central areas of MEMS micro hotplate arrays by a mask‐assistant method, leading the patterns with wafer‐level high consistency in thickness. The grain size and density of Pd nanoparticles modified on the surface of the SnO2 film are further regulated to obtain an optimized sensing performance. The resulting MEMS H2 sensing chips show a wide detection range from 0.5 to 500 ppm, high resolution, and good repeatability. Based on the experiments and density functional theory calculations, a sensing enhancement mechanism is also proposed: a certain amount of Pd nanoparticles modified on the SnO2 surface could bring stronger H2 adsorption followed by dissociation, diffusion, and reaction with surface adsorbed oxygen species. Obviously, the method provided here is quite simple and effective for the manufacturing of MEMS H2 sensing chips with high consistency and optimized performance, which may also find broad applications in other MEMS chip technologies.
Palladium‐Catalyzed Site‐Selective C7 Oxidative Arylation of 4‐EWG‐1H‐Indazoles
Authors: Ouazzani Chahdi Chaimae , Boujdi Khalid , El Brahmi Nabil , Mathé‐Allainmat Monique , Mouhi Eddine Hachim , Akssira Mohamed , Guillaumet Gérald , Lebreton Jacques , Koubachi Jamal , El Kazzouli Saïd 
Published: July 2023

AbstractAn efficient palladium‐catalyzed oxidative arylation of substituted 1H‐indazole with various arenes and heteroarenes as coupling partners is reported. A site selective C7 oxidative arylation was perfectly achieved with a directing electron‐withdrawing groups (EWG) located at the C4 position of the 1H‐indazole. The desired products are obtained in moderate to good yields from 4‐NO2 or 4‐CO2Me 1H‐indazoles and various (hetero)aryls as coupling partners in the presence of Pd(OAc)2 as catalyst, phenanthroline as ligand, Ag2CO3 as oxidant and NaOH as the base. Density functional theory was also conducted for reaction mechanism comprehension. This approach provides a highly effective, direct, and atom economical way to build C7‐ (het)arylated 1H‐indazole compounds.
Synthesis of a Porous [14]Annulene Graphene Nanoribbon and a Porous [30]Annulene Graphene Nanosheet on Metal Surfaces
Authors: Qin Tianchen , Guo Dezhou , Xiong Juanjuan , Li Xingyu , Hu Lei , Yang Weishan , Chen Zijie , Wu Yulun , Ding Honghe , Hu Jun , Xu Qian , Wang Tao , Zhu Junfa 
Published: July 2023

AbstractThe electrical and mechanical properties of graphene‐based materials can be tuned by the introduction of nanopores, which are sensitively related to the size, morphology, density, and location of nanopores. The synthesis of low‐dimensional graphene nanostructures containing well‐defined nonplanar nanopores has been challenging due to the intrinsic steric hindrance. Herein, we report the selective synthesis of one‐dimensional (1D) graphene nanoribbons (GNRs) containing periodic nonplanar [14]annulene pores on Ag(111) and two‐dimensional (2D) porous graphene nanosheet containing periodic nonplanar [30]annulene pores on Au(111), starting from a same precursor. The formation of distinct products on the two substrates originates from the different thermodynamics and kinetics of coupling reactions. The reaction mechanisms were confirmed by a series of control experiments, and the appropriate thermodynamic and kinetic parameters for optimizing the reaction pathways were proposed. In addition, the combined scanning tunneling spectroscopy (STS) and density functional theory (DFT) calculations revealed the electronic structures of porous graphene structures, demonstrating the impact of nonplanar pores on the π‐conjugation of molecules.
Pan‐cancer analyses reveal multi‐omic signatures and clinical implementations of the forkhead‐box gene family
Authors: Bi Xiaoman , Zheng Dehua , Cai Jiale , Xu Dahua , Chen Liyang , Xu Zhizhou , Cao Meng , Li Peihu , Shen Yutong , Wang Hong , Zheng Wuping , Wu Deng , Zheng Shaojiang , Li Kongning 
Published: July 2023

AbstractBackgroundForkhead box (FOX) proteins belong to one of the largest transcription factor families and play crucial roles in the initiation and progression of cancer. Prior research has linked several FOX genes, such as FOXA1 and FOXM1, to the crucial process of carcinogenesis. However, the overall picture of FOX gene family across human cancers is far from clear.MethodsTo investigate the broad molecular signatures of the FOX gene family, we conducted study on multi‐omics data (including genomics, epigenomics and transcriptomics) from over 11,000 patients with 33 different types of human cancers.ResultsPan‐cancer analysis reveals that FOX gene mutations were found in 17.4% of tumor patients with a substantial cancer type‐dependent pattern. Additionally, high expression heterogeneity of FOX genes across cancer types was discovered, which can be partially attributed to the genomic or epigenomic alteration. Co‐expression network analysis reveals that FOX genes may exert functions by regulating the expression of both their own and target genes. For a clinical standpoint, we provided 103 FOX gene‐drug target‐drug predictions and found FOX gene expression have potential survival predictive value. All of the results have been included in the FOX2Cancer database, which is freely accessible at http://hainmu‐biobigdata.com/FOX2Cancer.ConclusionOur findings may provide a better understanding of roles FOX genes played in the development of tumors, and help to offer new avenues for uncovering tumorigenesis and unprecedented therapeutic targets.
Integrating Ligands into Nucleic Acid Systems
Authors: Wang Yang , Liu Yan , Wang Liang‐Liang , Zhang Qiu‐Long , Xu Liang 
Published: July 2023

AbstractSignal transduction from non‐nucleic acid ligands (small molecules and proteins) to structural changes of nucleic acids plays a crucial role in both biomedical analysis and cellular regulations. However, how to bridge between these two types of molecules without compromising the expandable complexity and programmability of the nucleic acid nanomachines is a critical challenge. Compared with the previously most widely applied transduction strategies, we review the latest advances of a kinetically controlled approach for ligand‐oligonucleotide transduction in this Concept article. This new design works through an intrinsic conformational alteration of the nucleic acid aptamer upon the ligand binding as a governing factor for nucleic acid strand displacement reactions. The functionalities and applications of this transduction system as a ligand converter on biosensing and DNA computation are described and discussed. Furthermore, we propose some potential scenarios for utilization of this ligand transduction design to regulate gene expression through synthetic RNA switches in the cellular contexts. Finally, future perspectives regarding this ligand‐oligonucleotide transduction platform are also discussed.
Sex‐related differences in outcome after left atrial appendage occlusion: Insights from Europe and the EWOLUTION registry
Authors: Paitazoglou Christina , Eitel Ingo , Stiermaier Thomas , Ince Hueseyin , Kische Stephan , Pokushalov Evgeny , Schmitz Thomas , Schmidt Boris , Gori Tommaso , Meincke Felix , Vireca Elisa , Wohlmuth Peter , Lucas Boersma , Bergmann Martin W. ,   EWOLUTION Investigators
Published: July 2023

AbstractBackgroundWomen with atrial fibrillation (AF) generally experience worse symptoms, poorer quality of life, and have a higher risk of stroke and death. There is limited availability of sex‐related differences regarding left atrial appendage occlusion (LAAO).AimsThe aim of this study was to evaluate the sex‐related differences in patients undergoing LAAO in EWOLUTION.MethodsA total of 1025 patients scheduled for elective LAAO therapy employing the WATCHMAN Gen 2.5 prospectively consented for participation; 1005 patients received a successful implant and were followed for 2 years. As we detected sex‐related differences in baseline data we performed a propensity score matching. The primary endpoint is a combined endpoint of survival free from mortality, major bleeding, ischemic stroke, transitory ischemic attack (TIA) and systemic embolization (SE) up to 2‐year clinical follow‐up. Secondary Endpoints were periprocedural data and overall 2‐year survival.ResultsWomen were older but had less often vascular disease and hemorrhagic stroke. There was no sex‐related significant difference after LAAO at 2 years in the combined endpoint of survival free from mortality, major bleeding, ischemic stroke, TIA, and SE (female vs. male: 79% vs.76%, p = 0.24) or in overall survival (female vs. male: 85% vs. 82%, p = 0.16). Procedural data showed a higher sealing rate after the implantation in women (complete sealing female 94% vs. male 90%, p = 0.033), significantly more pericardial effusions (female 1.2% vs. male 0.2%, p = 0.031) and a similar periprocedural risk profile.ConclusionsFemales undergoing LAAO differ in various baseline variables, but after adjustment, we observed similar safety and efficacy of LAAO with no significant difference in long‐term outcomes between women and men.
Continuous Generation of Gas‐Water Slugs with Improved Size Uniformity at a Tunable Scale
Authors: Mou Mingyao , dela Rosa Loren , Mugumya Jethrine H. , Jiang Mo 
Published: July 2023

AbstractSlug flow has received increased interest due to the slugs serving as individual microreactors for enhanced process efficiency and product quality. In this study, slugs were continuously generated in various scales and sizes, with slug size uniformity studied by in‐line imaging. Different strategies of gas flow control and slug scale‐up were evaluated regarding the slug size distribution. With modified gas flow control, the slug uniformity was improved significantly. Slug flow can also be scaled up without sacrificing slug size uniformity, either by increasing the reservoir feeding volume or the flow rate. The type of gas used (air and nitrogen) to generate slugs does not affect the slug size uniformity. A narrow slug size distribution can improve the particle size distribution and, hence, lead to better product quality.