bluuebunny/crossref_metadata_2025_split huggingface dataset:
Variation in responses to incretin therapy: Modifiable and non-modifiable factors
Authors: Austin Gregory O. , Tomas Alejandra 
Published: April 2023

Type 2 diabetes (T2D) and obesity have reached epidemic proportions. Incretin therapy is the second line of treatment for T2D, improving both blood glucose regulation and weight loss. Glucagon-like peptide-1 (GLP-1) and glucose-stimulated insulinotropic polypeptide (GIP) are the incretin hormones that provide the foundations for these drugs. While these therapies have been highly effective for some, the results are variable. Incretin therapies target the class B G protein-coupled receptors GLP-1R and GIPR, expressed mainly in the pancreas and the hypothalamus, while some therapeutical approaches include additional targeting of the related glucagon receptor (GCGR) in the liver. The proper functioning of these receptors is crucial for incretin therapy success and here we review several mechanisms at the cellular and molecular level that influence an individual’s response to incretin therapy.
Effects of oleoylethanolamide supplementation on inflammatory biomarkers, oxidative stress and antioxidant parameters of obese patients with NAFLD on a calorie-restricted diet: A randomized controlled trial
Authors: Tutunchi Helda , Zolrahim Farideh , Nikbaf-Shandiz Mahlagha , Naeini Fatemeh , Ostadrahimi Alireza , Naghshi Sina , Salek Reza , Najafipour Farzad 
Published: April 2023

Background: Oxidative stress is considered a major factor in the pathophysiology of non-alcoholic liver disease (NAFLD). A growing body of evidence indicates that oleoylethanolamide (OEA), a bioactive lipid mediator, has anti-inflammatory and antioxidant properties. This trial investigated the effects of OEA administration on inflammatory markers, oxidative stress and antioxidant parameters of patients with NAFLD.Methods: The present randomized controlled trial was conducted on 60 obese patients with NAFLD. The patients were treated with OEA (250 mg/day) or placebo along with a low-calorie diet for 12 weeks. Inflammatory markers and oxidative stress and antioxidant parameters were evaluated pre-and post-intervention.Results: At the end of the study, neither the between-group changes, nor the within-group differences were significant for serum levels of high-sensitivity C-reactive protein (hs-CRP), interleukin-1 beta (IL-1β), IL-6, IL-10, and tumor necrosis-factor α (TNF-α). Serum levels of total antioxidant capacity (TAC) and superoxide dismutase (SOD) significantly increased and serum concentrations of malondialdehyde (MDA) and oxidized-low density lipoprotein (ox-LDL) significantly decreased in the OEA group compared to placebo at study endpoint (p = 0.039, 0.018, 0.003 and 0.001, respectively). Although, no significant between-group alterations were found in glutathione peroxidase and catalase. There were significant correlations between percent of changes in serum oxidative stress and antioxidant parameters with percent of changes in some anthropometric indices in the intervention group.Conclusion: OEA supplementation could improve some oxidative stress/antioxidant biomarkers without any significant effect on inflammation in NAFLD patients. Further clinical trials with longer follow-up periods are demanded to verify profitable effects of OEA in these patients.Clinical Trial Registration:www.irct.ir, Iranian Registry of Clinical Trials IRCT20090609002017N32.
Early human albumin administration is associated with reduced mortality in septic shock patients with acute respiratory distress syndrome: A retrospective study from the MIMIC-III database
Authors: Wang Xiya , Zhang Tianqian , Gao Xinzhen , Cai Hongbo , Guo Mengke , Liu Qi , Guo Shubin , Ji Wenqing 
Published: April 2023

Background: Sepsis-induced acute respiratory distress syndrome (ARDS) was associated with higher mortality. It is unclear whether albumin supplementation early in the course of ARDS can affect the prognostic outcomes of septic shock (SS) patients with ARDS.Methods: The MIMIC-III database was employed to identify SS patients with ARDS. The effect of early application (&lt;24 h after ICU admission) of human albumin on 28-day mortality in SS patients with ARDS was explored. The propensity score matching was used to minimize the bias between the non-albumin and early albumin treatment groups.Results: The analysis for all eligible patients who received human albumin showed significantly lower 28-hospital mortality rates than the non-albumin group (37% versus 47%, p = 0.018). After propensity matching, the difference between the two groups also significantly (34.8% versus 48.1%, p = 0.031). Moreover, we found that the relationship between albumin use and reduced 28-day mortality was inconsistent across SOFA score subgroups (Pinteraction = 0.004, non-adjustment for multiple testing).Conclusion: Early human albumin administration in SS patients with ARDS was independently associated with a reduction of 28-day mortality. Furthermore, the benefit of human albumin treatment appeared to be more pronounced in patients with a SOFA score of ≤ 10.
Spermiogenesis in Caenorhabditis elegans: An Excellent Model to Explore the Molecular Basis for Sperm Activation
Authors: Shimada Yoshihiro , Kanazawa-Takino Nana , Nishimura Hitoshi 
Published: April 2023

C. elegans spermiogenesis converts non-motile spermatids into motile, fertilization-competent spermatozoa. Two major events include the building of a pseudopod required for motility and fusion of membranous organelles (MOs)—intracellular secretory vesicles—with the spermatid plasma membrane required for the proper distribution of sperm molecules in mature spermatozoa. The mouse sperm acrosome reaction—a sperm activation event occurring during capacitation—is similar to MO fusion in terms of cytological features and biological significance. Moreover, C. elegans fer-1 and mouse Fer1l5, both encoding members of the ferlin family, are indispensable for MO fusion and acrosome reaction, respectively. Genetics-based studies have identified many C. elegans genes involved in spermiogenesis pathways; however, it is unclear whether mouse orthologs of these genes are involved in the acrosome reaction. One significant advantage of using C. elegans for studying sperm activation is the availability of in vitro spermiogenesis, which enables combining pharmacology and genetics for the assay. If certain drugs can activate both C. elegans and mouse spermatozoa, these drugs would be useful probes to explore the mechanism underlying sperm activation in these two species. By analyzing C. elegans mutants whose spermatids are insensitive to the drugs, genes functionally relevant to the drugs’ effects can be identified.
Enseñanza del Álgebra Lineal en estudiantes universitarios
Authors: Osorio Vidal Víctor Gilberto , Palomino Alca Julia Teresa , Huayhua Prada Mariluz Francisca , Gambini López Inés 
Published: April 2023

La asignatura de Álgebra Lineal es considerada dentro del currículo de las escuelas profesionales de las ciencias básicas, ingenierías, ciencias económicas y empresariales de las universidades como un curso de carácter formativo, además esta asignatura será útil para elaborar futuros proyectos cuando ejerzan su profesión. Se formuló como objetivo de estudio determinar la enseñanza del algebra lineal en estudiantes universitarios, examinando la literatura académica. Se empleó la metodología revisión sistemática seleccionando en bases de datos como: Google Académico, EBSCO, Scopus, Scielo, REDALYC y Dialnet. La revisión realizada permitió concluir que, enseñar este curso exige ciertas particularidades, los docentes haciendo uso de la didáctica deben motivar el interés, demostrando que los aprendizajes adquiridos serán útiles en el ejercicio profesional.
Estimating Victimization Rates, Trends and Risk Factors in Palestine
Authors: Okasha Mahmoud , NouralDin Nisreen 
Published: April 2023

This paper examines different risk factors that are most influential in identifying potential victims who have the greatest risk to be victimized in Palestine. The goal of this is to introduce a powerful statistical model that can be used in estimating the prevalence rates, trends and risk factors for a specific phenomenon such as victimization in Palestine as well as in other similar phenomena. The risk factors for being victimized in Palestine including many demographic, economic and social variables have been studied. The goal is to find those significant risk factors and identify the characteristics of the persons who are prone to tangible losses. The data used in the analysis cover all the Palestinian Territories including the West Bank, Gaza Strip and East Jerusalem as of 2008 and has been gathered by the Palestinian Central Bureau Of Statistics. Logistic regression model has been used in the analysis, and revealed that the significant influential factors on victimization are sex and owning a car. The effects of each factor, its odds ratio and risk ratio are examined. The model has been applied to estimate the probability of a person to be victimized and to classify the persons who are vulnerable to be victimized, and succeeded in correctly classifying 64% of people who have really fallen victims and 96% of people who are unbeatable to crime. The general percentage of correct classification was 93.5%.

تبحث هذه الورقة في عوامل المخاطرة المختلفة للإيذاء في فلسطين للتعرف على العوامل الأكثر تأثيرا في تحديد ضحايا الإيذاء المحتملين والمفيدة في التعرف على ضحايا الجريمة في فلسطين، كما تقدم الورقة أسلوباً إحصائياً متقدماً كنموذج لتحليل بيانات الإستبانات يمكن من خلاله تقدير معدلات واتجاهات ظاهرة معينة والتعرف على عوامل المخاطرة لها مثل ظاهرة الإيذاء في فلسطين، وقد تم دراسة معنوية العديد من عوامل المخاطرة على الإيذاء في فلسطين مثل عوامل المنطقة الجغرافية والمتغيرات الديموغرافية وبعض المتغيرات الاقتصادية والاجتماعية. وتهدف الورقة من خلال ذلك إلى التعرف على عوامل المخاطرة المعنوية والمؤثرة على الإيذاء وتحديد خصائص الأشخاص الأكثر عرضة لخسائر ملموسة. وقد بنيت الدراسة على تحليل إحصائي لبيانات عن المجتمع الفلسطيني تغطي كل الأراضي الفلسطينية بما فيها الضفة الغربية وقطاع غزة والقدس الشرقية خلال العام 2008، حيث تم الحصول على هذه البيانات من الجهاز المركزي للإحصاء الفلسطيني، وتم استخدم نموذج الانحدار اللوجستي الإحصائي في التحليل والكشف عن أكثر العوامل المعنوية إحصائياً تأثيرا على الإيذاء في فلسطين وتبين من التحليل أنها تمثلت في متغيري الجنس وامتلاك الأسرة لسيارة خاصة، كما تم فحص آثار كل عامل من عوامل المخاطرة، ونسب الخلاف والمخاطرة لكل متغير، إذ يمكن استخدام النموذج المقترح في تقدير احتمال أن يكون شخص ما ضحية للإيذاء خلال عام معين، وكذلك التعرف على فئة الأفراد الأكثر عرضة ليكونوا ضحايا محتملين، ونجح النموذج في تصنيف الأفراد الذين وقعوا ضحايا للإيذاء حقاً في عينة الدراسة بشكل صحيح بنسبة 64٪ من مفردات عينة الدراسة، ونسبة 96٪ من الأشخاص الذين لم يتعرضوا للإيذاء في فلسطين، وبشكل عام كانت نسبة التصنيف الصحيحة هي 93.5٪.
Second-stage potential-induced degradation of n-type front-emitter crystalline silicon photovoltaic modules and its recovery
Authors: Ohdaira Keisuke , Komatsu Yutaka , Yamaguchi Seira , Masuda Atsushi 
Published: April 2023

Abstract
We investigate the second-stage potential-induced degradation (PID) of n-type front-emitter (n-FE) crystalline silicon (c-Si) photovoltaic (PV) modules. The PID of n-FE c-Si PV modules is known to occur in three stages under negative bias stress. The second-stage PID is characterized by a reduction in fill factor (FF), due to the invasion of sodium (Na) into the depletion region of a p+–n junction and the resulting increase in recombination current. The second-stage PID shows a curious independence from a negative bias voltage for the PID stress. This may indicate that the Na inducing the FF reduction comes not from the cover glass but originally existed on and/or near the cell surface. The FF reduction is recovered quite rapidly, within a few seconds, by applying a positive bias to the degraded cell. The recovered n-FE c-Si PV modules show more rapid degradation if they receive the negative bias stress again, which can be explained by Na remaining in the p+ emitter.
Comparison of Modular Multilevel Converter based Solid State Transformer for ACDC application
Authors: Li Zhengzhao , Qin Zian , Mirzadarani Reza , Niasar Mohamad Ghaffarian , Bauer Pavol 
Published: April 2023

<p> For electrolyzer applications, traditional solutions using line frequency transformers plus rectifiers are bulky, heavy and have low controllability. The Solid State Transformer (SST) could be a promising solution to solve the mentioned issues. This paper compares the semiconductor ratings and capacitance of five different Modular Multilevel Converter (MMC) based Solid State Transformer (SST) topologies. The results show that the DRU-MMC based topologies have the lowest semiconductor ratings and capacitance. Because of the unidirectional power flow requirement, the source side MMC of Back-to-Back (BtB) MMC based SST could be replaced by DRU, thus the cost is drastically saved. Another interesting finding is that the DRU-MMC energy ripple is much lower than half of the energy ripple in BtB MMC, which is different from HVDC MMC. </p>
Multi-Linear Kernel Regression and Imputation in Data Manifolds
Authors: Nguyen Duc Thien , Slavakis Konstantinos 
Published: April 2023

<p>This paper introduces an efficient multi-linear non- parametric (kernel-based) approximation framework for data regression and imputation, and its application to dynamic magnetic-resonance imaging (dMRI). Data features are assumed to reside in or close to a smooth manifold embedded in a reproducing kernel Hilbert space. Landmark points are identified to describe concisely the point cloud of features by linear approximating patches which mimic the concept of tangent spaces to smooth manifolds. The multi-linear model effects dimensionality reduction, enables efficient computations, and extracts data patterns and their geometry without any training data or additional information. Numerical tests on dMRI data under severe under-sampling demonstrate remarkable improvements in efficiency and accuracy of the proposed approach over its predecessors, popular data modeling methods, as well as recent tensor-based and deep-image-prior schemes </p>
Studi Fenomenologi: Pengalaman Adaptasi Penderita Penyakit Menular Seksual
Authors: Kusuma Ratu , Pebrianti Dwi Kartika , Yesni Marnila , Yanti Rahmi Dwi 
Published: April 2023

Sexually transmitted diseases (STDs) are one of the causes of health, social and economic problems in many countries, and ± 500 million new cases of STDs occur every year worldwide. STDs are the gateway to HIV infection especially syphilis. Syphilis can increase the risk of contracting HIV up to 300 times. The negative consequences of STDs as infertility, stillbirth, congenital abnormalities and cervical cancer. The purpose of this study was to identify the experience of adaptation of STDs sufferers. A qualitative research with phenomenological approach to 10 participants (2 syphilis patients and 8 HIV/AIDS) which were selected purposively. Data collected using in-depth interview, observations and documentation. Interviews were IMS Clinic and VCT Puskesmas Putri Ayu and HIV/AIDS sufferers communities in Kota Jambi (Yayasan Kanti Sehati Sejati). Data collection on January 13-16 February 2021, personal interviews last 60-75 minutes and concurrent interviews are 75-120 minutes, recorded with a voice recorder. Data were analyzed descriptively through theme analysis, results 7 themes related to the experience of adaptation of STDs sufferers: 1) complaints and physical complications of STDs sufferers; 2) the psychological impact of STDs; 3) STD risk factors; 4) STDs treatment; 5) efforts to prevent recurrence/severity; 6) coping mechanisms for PMS sufferers; and 7) behavioral responses of STDs sufferers: physiological, self-concept, role function and interdependence.
PELATIHAN KETERAMPILAN WEB DESIGN BAGI SISWA SMK NEGERI 1 SURABAYA
Authors: Titus Kristanto  , Dewi Rahmawati  , Arliyanti Nurdin  , Fidi Wincoko Putro  , Ardian Yusuf Wicaksono  , Mohammad Sholik  
Published: April 2023

SMK Negeri 1 Surabaya merupakan sekolah kejuruan negeri favorit di Surabaya. Lokasi SMK Negeri 1 Surabaya berdekatan dengan RSI Ahmad Yani Surabaya. Kegiatan Pengabdian kepada Masyarakat (PkM) ini dilandasi pemikiran bahwa pada era milenial ini, SMK Negeri 1 Surabaya harus dapat bersaing dengan sekolah kejuruan lain, baik sekolah negeri maupun swasta, entah di kota Surabaya sendiri ataupun di kota-kota lain. Solusi yang ditawarkan dari Institut Teknologi Telkom Surabaya dalam mengikuti perkembangan zaman adalah pelatihan keterampilan web design yang ditujukan bagi para siswa SMK Negeri 1 Surabaya Jurusan Multimedia dan Jurusan Rekayasa Perangkat Lunak. Tujuan kegiatan pelatihan keterampilan ini adalah untuk meningkatkan kemampuan siswa SMK Negeri 1 Surabaya dalam membuat dan mengelola web secara mandiri. Pelatihan keterampilan web design ini melibatkan dosen dan mahasiswa dari program studi Rekayasa Perangkat Institut Teknologi Telkom Surabaya. Hasil kegiatan pelatihan keterampilan web design adalah para siswa mampu merancang dan mengelola web secara mandiri, mulai dari tingkat dasar sampai tingkat dinamis.
Toxidermies graves en réanimation
Authors: GAILLET Antoine , Ingen-Housz-Oro Saskia , Chosidow Olivier , De Prost Nicolas 
Published: April 2023

Les toxidermies graves (nécrolyse épidermique, drug reaction with eosinophilia and systemic symptoms (DRESS) et pustulose exanthémathique aiguë généralisée (PEAG)) sont des situations complexes, tant dans leur approche diagnostique que thérapeutique, justifiant une prise en charge multidisciplinaire en centre spécialisé. En plus de l’atteinte cutanéo-muqueuse, des complications viscérales peuvent advenir, engageant le pronostic vital à court terme. La prise en charge initiale, essentiellement symptomatique, a, par ailleurs, pour but de prévenir d’éventuelles séquelles à long-terme. Les médecins doivent être conscients du rôle potentiel des médicaments à haut risque dans le déclenchement de toxidermies graves, en particulier lorsque des facteurs prédisposants sont présents. Toutes les toxidermies graves doivent être déclarées en pharmacovigilance. A distance, les tests allergologiques peuvent aider à confirmer le médicament coupable et à décider des alternatives possibles.
Bounds on Half Graph Orders in Powers of Sparse Graphs
Authors: Sokołowski Marek 
Published: April 2023

Half graphs and their variants, such as semi-ladders and co-matchings, are configurations that encode total orders in graphs. Works by Adler and Adler (Eur. J. Comb.; 2014) and Fabiański et al. (STACS; 2019) prove that in powers of sparse graphs, one cannot find arbitrarily large configurations of this kind. However, these proofs either are non-constructive, or provide only loose upper bounds on the orders of half graphs and semi-ladders.In this work we provide nearly tight asymptotic lower and upper bounds on the maximum order of half graphs, parameterized by the power, in the following classes of sparse graphs: planar graphs, graphs with bounded maximum degree, graphs with bounded pathwidth or treewidth, and graphs excluding a fixed clique as a minor.
The most significant part of our work is the upper bound for planar graphs. Here, we employ techniques of structural graph theory to analyze semi-ladders in planar graphs via the notion of cages, which expose a topological structure in semi-ladders. As an essential building block of this proof, we also state and prove a new structural result, yielding a fully polynomial bound on the neighborhood complexity in the class of planar graphs.
The Role of Educational Support, Social Support, Income Expectations and Personality on Student's Entrepreneurial Interests in Riau, Indonesia
Authors: Purwati Astri Ayu , Hamzah Muhammad Luthfi , Hamzah Zulfadli , Rusilawati Ermina 
Published: April 2023

Every year there are university graduates who should be able to improve the quality of human resources in Indonesia. The reality is that college graduates are more directed to the formal sector so when jobs in the legal industry do not grow, people do not try to create their careers. This research aims to analyse the effect of Higher Education Learning Support, Social Support, Income Expectations and Personality on Student Entrepreneurial Interests in Riau, Indonesia. The sample in this research is 400 students in Pekanbaru, Riau. The population in this study were final semester students (6,7,8) at a university in Pekanbaru, Riau. And by using research samples taken from as many as 400 people according to the sample criteria with solving calculations. The data analysis technique used tested the validity and reliability as well as the hypothesis as evidenced by multiple linear regression analysis. Based on the study's results, it can be concluded that the variables in this study consisting of college support, social support, income expectations and personality significantly influence student interest in Riau.
Keywords: Educational Support, Social Support, Income Expectations, Personality, Entrepreneurial Interest
The Hα Luminosity Function of Galaxies at z ∼ 4.5
Authors: Bollo Victoria , González Valentino , Stefanon Mauro , Oesch Pascal A. , Bouwens Rychard J. , Smit Renske , Illingworth Garth D. , Labbé Ivo 
Published: April 2023

Abstract
We present the Hα luminosity function (LF) derived from a large sample of Lyman break galaxies at z ∼ 4.5 over the GOODS-South and North fields. This study makes use of the new, full-depth Spitzer/IRAC [3.6] and [4.5] imaging from the GOODS Re-ionization Era wide-Area Treasury from the Spitzer program. The Hα flux is derived from the offset between the continuum flux estimated from the best-fit spectral energy distribution, and the observed photometry in IRAC [3.6]. From these measurements, we build the Hα LF and study its evolution providing the best constraints of this property at high redshift, where spectroscopy of Hα is not yet available. Schechter parameterizations of the Hα LF show a decreasing evolution of Φ∗ with redshift, increasing evolution in L
∗, and no significant evolution in the faint-end slope at high z. We find that star formation rates (SFRs) derived from Hα are higher than those derived from the rest-frame UV for low SFR galaxies but the opposite happens for the highest SFRs. This can be explained by lower mass galaxies (also lower SFR) having, on average, rising star formation histories (SFHs), while at the highest masses the SFHs may be declining. The SFR function is steeper, and because of the excess SFR(Hα) compared to SFR(UV) at low SFRs, the SFR density estimated from Hα is higher than the previous estimates based on UV luminosities.