bluuebunny/crossref_metadata_2025_split huggingface dataset:
Misdiagnosis of placental mesenchymal dysplasia as pregnancy with hydatidiform mole: A case report and literature review
Authors: Tang Ping , Jin Xiaoying , Li Jiarui , Zhang Liyan , Li Yuan , Xu Shengfeng 
Published: April 2023

Rationale:
Placental mesenchymal dysplasia (PMD) is a rare placental disease frequently associated with severe maternal and/or fetal complications. Its sonographic appearance is very similar to that of a hydatidiform mole. Hence, PMD is easily misdiagnosed as a hydatidiform mole. In this study, we reported the clinical features of PMD and analyzed its relationship to other severe maternal and/or fetal complications.

Patient concerns:
A 28-year-old female, gravida 2, para 1, was referred to our maternal and child health hospital at 15 weeks + 2 days due to an ultrasonic diagnosis of partial hydatidiform mole. Analysis of chromosome karyotype + mononucleotide-based gene microarray by amniocentesis at the 19th week of gestation showed that fetal amniocentesis chromosome 46, XN, high-resolution chromosome microarray analysis of Affymetrix CytoScan 750K Array revealed a 210 kb fragment deletion in chromosome 2p16.3 containing NRXN1, an OMIM gene, the deleted fragment was derived from a mother with a normal phenotype. The pregnant woman delivered a healthy baby girl at 36 weeks + 5 days.

Diagnoses:
Based on the clinical characteristics, imaging, and genetic test findings, the postoperative diagnosis was PMD.

Intervention:
Because of “Scar uterus” and “Pregnancy with hydatidiform mole,” a 2490 g female infant was delivered by cesarean section at 36 weeks + 5 days of gestation with an Apgar score of 9/9.

Outcomes:
The maternal human chorionic gonadotropin level decreased to the normal range after 10 days of delivery, and the infant was not found abnormal after 3 months of follow-up.

Lessons:
From our cases and 19 other cases obtained from the PMD literature review are associated with unique clinical, laboratory, and imaging features compared with a hydatidiform mole, such as stained glass sign, normal serum levels of serum human chorionic gonadotropin, elevated alpha-fetoprotein levels and female fetus.
Acute cervical radiculopathy after anterior scalene muscle massage: A case report
Authors: Chung Sung Joon , Soh Yunsoo 
Published: April 2023

Rationale:
Deep tissue massage (DTM) is a form of therapeutic massage therapy for muscles and is often used to treat musculoskeletal pain. This was an uncommon case of acute cervical radiculopathy that occurred after DTM.

Patient concerns:
A 47-year-old Asian woman with low weight visited our clinic due to complaints of sudden unilateral paralysis, radiating pain in the left shoulder, and wrist weakness after undergoing a 3-minute DTM of the anterior scalene muscle. Electrodiagnostic examination indicated acute injuries in the left cervical 5 and 6 (cervical 5 and cervical 6) nerve roots.

Diagnoses:
Acute cervical radiculopathy associated with anterior scalene DTM.

Intervention:
The patient underwent ultrasound-guided cervical 5 and cervical 6 selective nerve root block twice through the injection of 0.25% lidocaine and 20 mg dexamethasone and regularly participated in a biweekly rehabilitation program and a home exercise program.

Outcome:
After a 6-month follow-up, the patient’s shoulder and wrist strength had recovered, and the electrodiagnostic findings had improved.

Lessons:
DTM of the anterior scalene muscle should be carefully performed to avoid cervical nerve root injury, particularly in underweight patients.
Oxidized Regenerated Cellulose Versus Calcium Alginate in Controlling Bleeding From Malignant Wounds
Authors: Firmino Flávia , Villela-Castro Diana , Santos Vera Lucia Conceição de Gouveia 
Published: April 2023

Background
There is no consensus on the best intervention for topical management of bleeding in malignant wounds. Although surgical hemostatic dressings are recommended, the use of calcium alginate (CA) is frequent among practitioners.

Objective
The aim of this study was to evaluate the hemostatic efficacy of oxidized regenerated cellulose (ORC) and CA dressing in the management of bleeding from malignant wounds resulting from breast cancer.

Methods
This was a randomized open clinical trial. The outcomes measured were total time to hemostasis and the number of hemostatic products used.

Results
Sixty-one patients were potentially eligible for the study, 1 did not consent, and 32 were assessed to be ineligible, resulting in a sample of 28 who were randomized to 2 study groups. Total time to hemostasis was 93.8 seconds in the ORC group, with an average of 30.1 seconds (95% confidence interval, 18.6-189 seconds), and 67 seconds in the CA group, with an average of 30.4 seconds (confidence interval, 21.7 seconds to imprecise upper limit). The main difference was 26.8 seconds. Kaplan-Meier log-rank test, and Cox model showed no statistical significance (P = 0.894). A total of 18 hemostatic products were used in the CA group and 34 in the ORC group. No adverse effects were identified.

Conclusions
Although no significant differences were identified in terms of time, more hemostatic products were used in the ORC group, highlighting the effectiveness of CA.

Implications for Practice
Calcium alginate may be the first choice in the management of bleeding in malignant wounds, favoring nursing in the most immediate hemostatic actions.
Does “Low-Grade” Dedifferentiated Liposarcoma Exist? The Role of Mitotic Index in Separating Dedifferentiated Liposarcoma From Cellular Well-differentiated Liposarcoma
Authors: Graham Danielle S. , Qorbani Amir , Eckardt Mark A. , Klingbeil Kyle D. , Chen Lucia Y. , Chopra Shefali , Eilber Fritz C. , Dry Sarah M. 
Published: April 2023

Background:
Subjective, varying criteria identify “low-grade” dedifferentiation in well-differentiated/dedifferentiated liposarcoma (WD/DDLPS). The value of mitotic rate (MR) in defining DDLPS is not confirmed. We studied all patients with the resection of their primary or first recurrence retroperitoneal WD/DDLPS at our institution to determine the value of MR in diagnosing DDLPS and if MR associates with patient survival.

Design:
Ninety-eight patients with retroperitoneal WD/DDLPS operated at our institution from January 1, 1989 to December 31, 2013 were included. Cases were defined as acellular (AC) WDLPS, LS0-4 (tumors with non-lipogenic areas and MR 0-4/10HPFs) or LS5+(non-lipogenic areas, MR≥5/10 HPFs) and graded using the French system. Kaplan-Meier survival estimates with log-rank test and multivariate Cox (mCox) analyses were performed.

Results:
Follow-up was available on all patients (median 9.3 y, range 0.02−23.16 y). Kaplan-Meier demonstrated a significant (P=0.004) difference in disease-specific survival (DSS) among the 3 groups. mCox demonstrated no difference in DSS between the AC and LS0-4 groups (HR 1.51; 95% CI 0.57–3.99, P=0.412) but significantly lower DSS in the LS5+group compared with the AC group (HR 2.68; 95% CI 1.07–6.71, P=0.035). The difference in DSS was not significant between grade 2 and 3 tumors (P=0.094). DSS between MR 5-19/10 HPFs and MR20+/10 HPFs subgroups was significant (P=0.007) but by mCox did not reach significance (HR 2.47; 95% CI 0.96–6.35, P=0.060).

Conclusion:
This study confirms that MR distinguishes DDLPS from WDLPS with non-lipogenic areas, also known as cellular WDLPS. For consistency in diagnosis and research, only WD/DDLPS with≥5 mitoses/10 HPFs should be considered DDLPS.
Back to the Future II—A Comprehensive Update on the Rapidly Evolving Field of Lymphatic Imaging and Interventions
Authors: Pieper Claus C. 
Published: April 2023

AbstractLymphatic imaging and interventional therapies of disorders affecting the lymphatic vascular system have evolved rapidly in recent years. Although x-ray lymphangiography had been all but replaced by the advent of cross-sectional imaging and the scientific focus shifted to lymph node imaging (eg, for detection of metastatic disease), interest in lymph vessel imaging was rekindled by the introduction of lymphatic interventional treatments in the late 1990s. Although x-ray lymphangiography is still the mainstay imaging technique to guide interventional procedures, several other, often less invasive, techniques have been developed more recently to evaluate the lymphatic vascular system and associated pathologies. Especially the introduction of magnetic resonance, and even more recently computed tomography, lymphangiography with water-soluble iodinated contrast agent has furthered our understanding of complex pathophysiological backgrounds of lymphatic diseases. This has led to an improvement of treatment approaches, especially of nontraumatic disorders caused by lymphatic flow abnormalities including plastic bronchitis, protein-losing enteropathy, and nontraumatic chylolymphatic leakages. The therapeutic armamentarium has also constantly grown and diversified in recent years with the introduction of more complex catheter-based and interstitial embolization techniques, lymph vessel stenting, lymphovenous anastomoses, as well as (targeted) medical treatment options. The aim of this article is to review the relevant spectrum of lymphatic disorders with currently available radiological imaging and interventional techniques, as well as the application of these methods in specific, individual clinical situations.
Single-nuclei RNA Profiling Reveals Disruption of Adipokine and Inflammatory Signaling in Adipose Tissue of Burn Patients
Authors: Knuth Carly M. , Ricciuti Zachary , Barayan Dalia , Rehou Sarah , Abdullahi Abdikarim , de Brito Monteiro Lauar , Jeschke Marc G. 
Published: April 2023

Objective:
We conducted a large-scale investigation of the systemic and adipose tissue-specific alterations in a clinical population of burn patients to identify factors that may influence hypermetabolism.

Background:
Previous research has identified chronic disturbances in adipose tissue inflammation, lipolysis, and browning, which may drive the perpetuation of hypermetabolism following the severe adrenergic stress of a burn injury. Given that adipose tissue is thought to be a central node in the regulation of systemic metabolism, we believe that systematically delineating the pathologic role of adipose tissue postburn, will lead to the identification of novel interventions to mitigate morbidity and mortality from severe burns.

Methods:
This was a single-institution cohort study, which obtained plasma and subcutaneous adipose tissue samples from severely burn adult patients over various time points during acute hospitalization. Whole-body clinical, metabolic, and inflammatory mediators were assessed in plasma, while genetic analyses through RT-qPCR and single-nuclei RNA sequencing were conducted in adipose tissue.

Results:
Systemic inflammation and adrenergic stress increase IL-6 signaling, lipolysis, browning, and adipokine dysfunction in the adipose tissue of adult burn patients, which may further propagate the long-term hypermetabolic response. Moreover, using single-nuclei RNA sequencing, we provide the first comprehensive characterization of alterations in the adipose tissue microenvironment occurring at acute and chronic stages postburn.

Conclusion:
We provide novel insight toward the effect of burns on adipokine release, inflammatory signaling pathways, and adipose heterogeneity over the trajectory of acute and chronic stages.
Paraflavisolibacter caeni gen. nov., sp. nov., a novel taxon within the family Chitinophagaceae isolated from sludge
Authors: Yuan Cansheng , Liu Bin , Wang Lin , Long Weihua , Ke Zhuang , He Jian 
Published: April 2023

A Gram-stain-negative bacterium, designated strain LB-8T, was isolated from an activated sludge sample collected from a factory in Binzhou city, Shandong province, PR China. Cells of strain LB-8T were strictly aerobic, non-motile and rod-shaped. Growth occurred at 15–40 °C (optimum, 30 °C), at pH 6.0–9.0 (optimum, pH 7.0) and at 0–7.5 % (w/v) NaCl (optimum, 0.5 % NaCl). Phylogenetic analysis based on 16S rRNA gene sequences indicated that strain LB-8T formed a distinct phyletic branch within the family

Chitinophagaceae

and was most closely related to members of the genera

Flavisolibacter

,

Cnuella

and

Paracnuella

with 92.7–93.3 % 16S rRNA gene sequence similarities. The average amino acid identity values between strain LB-8T and its closed phylogenetic neighbours

Flavisolibacter

,

Cnuella

and

Paracnuella

were below 70 % supporting that strain LB-8T was a member of a novel genus. The predominant cellular fatty acids of LB-8T were iso-C15 : 0, anteiso-C15 : 0, summed feature 3 (C16 : 1
ω7c and/or C16 : 1
ω6c) and iso-C17 : 0 3-OH, and the only isoprenoid quinone was menaquinone-7 (MK-7). The major polar lipids of strain LB-8T were phosphatidylethanolamine, four unidentified aminolipids and two unidentified lipids. The genome size of strain LB-8T was 7.01 Mbp with 41.2 mol% G+C content. On the basis of the evidence presented in this study, strain LB-8T represents a novel species of a new genus in the family

Chitinophagaceae

, for which the name Paraflavisolibacter caeni gen. nov., sp. nov. (type strain LB-8T=GDMCC 1.3631T=KCTC 92688T) is proposed.
Intended versus implemented workspace: a systematic literature review of the implementation of activity-based working in higher education
Authors: Nooij Bernadette , van Teunenbroek Claire , Teelken Christine , Veenswijk Marcel 
Published: April 2023

PurposeThe purpose of this study is to apply spatial theory to a review of the literature on activity-based working in higher education. Globally, the office concept of activity-based working (ABW) is increasingly implemented in higher education, and scholars contributed to developing empirical explanations of the effects of implementing ABW in higher education. However, the focus on theory building is limited, decreasing the predictability and the understanding of implementing ABW.Design/methodology/approachThe authors developed a theoretical framework by categorizing the empirical findings of earlier accounts by integrating them with Lefebvre’s spatial theory. They conducted a systematic literature review of 21 studies published between 2008 and 2022 that reported on the phenomenon of ABW among higher-education employees.FindingsIt remains to be seen whether the implementation of the ABW in higher education is successful in terms of pre-defined goals. The studies investigating academic workplace concepts have led to inconsistent findings that lack an underlying framework. As the ABW concept fails to adequately support academics’ work processes, it is recommended that managers and architects consider their subjective perspectives about the use of space and take the time to understand the users’ fundamental values.Originality/valueThe authors integrated the selected studies with Lefebvre’s spatial theory, and this model includes three perspectives that can explain workers' experiences with ABW. This theoretical framework can assist researchers in gaining a deeper understanding of ABW and support practitioners in implementing it in higher education.
Data-driven augmentation of a RANS turbulence model for transonic flow prediction
Authors: Grabe Cornelia , Jäckel Florian , Khurana Parv , Dwight Richard P. 
Published: April 2023

Purpose
This paper aims to improve Reynolds-averaged Navier Stokes (RANS) turbulence models using a data-driven approach based on machine learning (ML). A special focus is put on determining the optimal input features used for the ML model.

Design/methodology/approach
The field inversion and machine learning (FIML) approach is applied to the negative Spalart-Allmaras turbulence model for transonic flows over an airfoil where shock-induced separation occurs.

Findings
Optimal input features and an ML model are developed, which improve the existing negative Spalart-Allmaras turbulence model with respect to shock-induced flow separation.

Originality/value
A comprehensive workflow is demonstrated that yields insights on which input features and which ML model should be used in the context of the FIML approach
Wind tunnel measurements of dynamic aerodynamic coefficients using a freely rotating test bench
Authors: Muller Laurène , Libsig Michel , Bailly Yannick , Roy Jean-Claude 
Published: April 2023

Purpose
This paper aims to propose a dedicated measurement methodology able to simultaneously determine the stability derivative Cmα and the pitch damping coefficient sum Cmq + Cmα in a wind tunnel using a single and almost non-intrusive metrological setup called MiRo.

Design/methodology/approach
To assess the MiRo method’s reliability, repeatability and accuracy, the measurements obtained with this technique are compared to other sources like aerodynamic balance measurements, alternative wind tunnel measurements, Ludwieg tube measurements, free-flight measurements and computational fluid dynamics (CFD) simulations. Two different numerical approaches are compared and used to validate the MiRo method. The first numerical method forces the projectile to describe a pure oscillation motion with small amplitude along the pitch axis during a rectilinear flight, whereas the second numerical approach couples the one degrees of freedom simulation motion equations with CFD methods.

Findings
MiRo, a novel and almost non-intrusive technique for dynamic wind tunnel measurements, has been validated by comparison with five other experimental and numerical methodologies. Despite two completely different approaches, both numerical methods give almost identical results and show that the holding system has nearly no impact on the dynamic aerodynamic coefficients. Therefore, it could be assessed that the attitude of MiRo model in the wind tunnel is very close to the free-flight one.

Originality/value
The MiRo method allows studying the attitude of a projectile in a wind tunnel with the least possible impact on the flow around a model.
Enhanced lubrication by core-shell TiO2 nanoparticles modified with PEG-400
Authors: Wei Yukun , Dai Leyang , Fang YanFei , Sheng Chen Xing , Rao Xiang 
Published: April 2023

Purpose
The purpose of this paper is to enhance the characteristics of TiO2 nanoparticles (NPs). Because these NPs stick together easily and are difficult to distribute evenly, they cannot be used extensively in lubricating oils. Altering TiO2 was recommended as an alternate way for making NPs simpler to disperse.

Design/methodology/approach
Through dielectric barrier discharge plasma (DBDP)-assisted ball mill diagnostics and modeling of molecular dynamics, TiO2@PEG-400 NPs were produced using the DBDP-assisted ball mill. The NPs’ microstructure was examined using FESEM, TEM, XRD, FT-IR and TG-DSC. Using the CFT-1 reciprocating friction tester, the tribological properties of TiO2@PEG-400 NPs as base oil additives were studied. EDS and XPS were used to examine the surface wear of the friction pair.

Findings
Tribological properties of the modified NPs are vastly superior to those of the original NPs, and the lipophilicity value of TiO2 NPs was improved by 200%. It was determined through tribological testing that TiO2@PEG-400’s exceptional performance might be attributable to a chemical reaction film made up of TiO2, Fe2O3, iron oxide and other organic chemicals.

Originality/value
This work describes an approach for preventing the aggregation of TiO2 NPs by coating their surface with PEG-400. In addition, the prepared NPs can enhance the tribological performance of lubricating oil. This low-cost, high-performance lubricant additive has tremendous promise for usage in marine engines to minimize operating costs while preserving navigational safety.
Increasing employer willingness to hire people with disability: the perspective of disability employment service providers
Authors: Mahasneh Rola , Randle Melanie , Gordon Rob , Algie Jennifer , Dolnicar Sara 
Published: April 2023

Purpose
This study aims to investigate which factors are associated with the willingness of employers to hire people with disability from the perspective of disability employment service providers. We also identify social marketing approaches that disability employment service providers consider to be most effective in increasing employer willingness to hire people with disability.

Design/methodology/approach
Using the framework of the theory of planned behavior, this study examines the association of attitude, subjective norms and perceived behavioral control with employer willingness to hire people with disability. The authors do this from the perspective of disability employment service providers, who are responsible for matching people with disability with suitable employment opportunities. The authors used a qualitative approach to data collection and conducted 30 in-depth interviews. Data analysis included deductive and inductive coding to develop the themes and subthemes.

Findings
Attitude, subjective norms and perceived behavioral control were all perceived to influence employers’ willingness to hire people with disability. However, the importance of each construct was perceived to differ by location and organization type. Three key social marketing approaches were perceived to be most effective in increasing employer willingness to hire people with disability: educational, relational and interactive. The educational intervention attempts to increase employers’ knowledge about disability, the relational approach aims to develop relationships within the community to strengthen relationships with employers and the interactive approach involves direct contact between employers and people with disability.

Originality/value
Theoretically, this study reveals perceived heterogeneity in terms of the theoretical constructs that are employer hiring decisions. Practically, results help disability employment service providers design social marketing strategies that are effective in reducing barriers and increasing employment for people with disability. Methodologically, this study adds a new perspective on employer willingness to hire people with disability – that of disability employment service providers – which avoids the social desirability bias found in many self-reported studies of employer attitudes and behavior.
Do organizational commitment and consumer satisfaction mediate the relationship corporate social responsibility-sustainable performance? Assessing happiness management in Spanish wineries
Authors: Martínez-Falcó Javier , Sánchez-García Eduardo , Marco-Lajara Bartolomé , Millan-Tudela Luis A. 
Published: April 2023

PurposeThe research aims to analyze the effect of corporate social responsibility (CSR) on sustainable performance (SP), as well as the mediating effect of organizational commitment (OC) and consumer satisfaction (CS) on this link. In addition, the variables age, size and membership of a Protected Designation of Origin (PDO) are included as control variables to increase the precision of the cause–effect relationships under study.Design/methodology/approachA theoretical model is formulated to achieve the proposed research objectives, which is then tested by structural equation modeling (PLS-SEM) on the basis of primary data obtained from a survey of 196 Spanish wineries between September 2022 and January 2023.FindingsThe findings of the research show that CSR has a positive and significant effect on the SP of wineries, demonstrating also the mediating effect of OC and CS in this link.Originality/valueThere are several reasons that justify the originality of this study. First, the present research advances the knowledge and understanding of the meaning of the CSR–SP relationship of wineries. Secondly, to our knowledge, there are no previous studies that have analyzed OC and CS as measurement variables in the CSR–SP link in the wine context, so the study provides new scientific knowledge. Thirdly, to the best of our knowledge, the proposed theoretical model has not been previously tested, so the study advances the academic literature and management decisions on CSR and sustainability.