bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hereditary coagulation factor VII deficiency caused by novel compound heterozygous mutations in a Chinese pedigree: A case report
Authors: Cai Ruimin , Li Yi , Xu Wei , Gao Xue , Feng Qiang 
Published: December 2022

AbstractBackgroundCongenital coagulation factor VII (FVII) deficiency is a rare, autosomal‐recessive haemorrhagic disorder with an estimated incidence of 1:500,000. This disorder is caused by mutations in the F7 gene.Case descriptionHere, we report a pedigree of congenital FVII deficiency. The proband was a 30‐year‐old female with severely low FVII activity and a history of menorrhagia and epistaxis since her childhood who was subsequently diagnosed with congenital compound heterozygous FVII deficiency. A genetic study revealed a novel combination of compound heterozygous mutations (c.64G 〉 A, p.Gly22Ser and c.1027G 〉 A, p.Gly343Ser). Her father and older son had the c.64G 〉 A, p.Gly22Ser (heterozygous) mutation. Her mother and younger son had the c.1027G 〉 A, p.Gly343Ser (heterozygous) mutation. The predicted results of PolyPhen‐2 and MutationTaster indicated that these mutations were probably damaging and disease‐causing, respectively.ConclusionIn this study, we identified a novel combination of genetic mutations that could expand the mutant library and help in elucidating the pathogenesis of hereditary human coagulation FVII deficiency. A novel combination of compound heterozygous mutations was reported for the first time in Chinese individuals.
Utility of SCORE2 risk algorithm for predicting life course accelerated frailty and physical function decline
Authors: Li Chenglong , Ma Yanjun , Hua Rong , Zheng Fanfan , Xie Wuxiang 
Published: December 2022

AbstractBackgroundFrailty is a dynamic process that increases with ageing, while it remains unclear whether cardiovascular disease (CVD) risk algorithm could predict life course dynamic frailty trajectories, for example, the longitudinal patterns of how frailty evolves with time. We intended to examine the predictive utility of the Systemic Coronary Risk Estimation 2 (SCORE2) algorithm for life course accelerated frailty and physical function decline, in comparison with the precedent SCORE algorithm.MethodsLongitudinal data regarding accumulation of deficits frailty index (FI) and physical function (grip strength, gait speed, peak expiratory flow and timed chair rises) were drawn from the English Longitudinal Study of Ageing (ELSA) and Health and Retirement Study (HRS), two nationally representative cohorts with community‐dwelling adults aged ≥50 years. SCORE and SCORE2 were calculated at baselines following European Society of Cardiology guidelines. A group‐based trajectory modelling approach was used for identifying potential life course frailty trajectories, based on 14‐ and 12‐year FI data in the ELSA and HRS. Modified Poisson regression and linear mixed model were applied for analysing associations between SCORE2 with accelerated frailty trajectory and physical function decline, respectively. Receiver operating characteristic curve (ROC) analysis was conducted to evaluate predictive utility for accelerated frailty increase trajectory of SCORE and SCORE2, with the area under the curve (AUC) compared using the paired DeLong's test.ResultsA total of 4834 participants from the ELSA and 7815 participants from the HRS were included (mean age: 64.0 ± 9.2 and 65.4 ± 9.9 years; men: 44.3% and 41.4%, respectively). Three frailty trajectories were consistently identified in both cohorts: (1) stable frailty increase (n = 3026 in ELSA and 4004 in HRS); (2) moderate frailty increase (n = 1325 in ELSA and 2955 in HRS); (3) accelerated frailty increase (n = 483 in ELSA and 856 in HRS). Each 10% increment in SCORE2 risk was associated with the higher risk of accelerated frailty increase (risk ratio [RR]: 3.58, 95% confidence interval [CI] [3.22, 3.98], P < 0.001 in ELSA; RR: 1.61, 95% CI [1.56, 1.67], P < 0.001 in HRS) and faster declines in all physical function measurements. SCORE2 algorithm showed good accuracy for predicting accelerated frailty increase (area under the curve [AUC] in ELSA: 0.759; HRS: 0.744), with better performance than the SCORE (AUC in ELSA: 0.729; HRS: 0.700) in both cohorts (P < 0.001 for comparison).ConclusionsSCORE2 algorithm could serve good utility for predicting life course accelerated frailty increase and physical function decline among community‐dwelling non‐frail adults aged ≥50 years.
Evaluation of drug release, monomer conversion and surface properties of resin composites containing chlorhexidine‐loaded mesoporous and nonporous hydroxyapatite nanocarriers
Authors: Demirbuğa Sezer , Dayan Serkan , Balkaya Hacer 
Published: December 2022

AbstractThe aim of this study was to evaluate drug release, degree of conversion (DC), and surface properties of resin composites containing chlorhexidine (CHX)‐loaded mesoporous (mHAP) and nonporous hydroxyapatite (HAP) nanocarrier. CHX loaded mHAP and HAP, or CHX without nanocarrier was added into the resin composite in 1% and 5% concentrations. After characterization of experimental materials with XRD, EDX, FT‐IR, and SEM, the CHX release on the 1st, 7th, 30th, and 120th days were evaluated by UV–vis spectroscopy. DC, surface roughness, and surface hardness of the samples were also evaluated. The data was statistically analyzed. While mHAP groups released significantly higher CHX on the 30th day (p < .05), there was no statistically significant difference between the HAP and mHAP groups on the 120th day (p > .05). DCs of all groups were similar (p > .05). While mHAP and HAP groups containing 5% CHX showed significantly higher roughness than the other groups (p < .05), no statistically significant difference was observed between the other groups (p > .05). The 1% and 5% CHX groups without nanocarrier showed significantly lower surface hardness (p < .05). However, no statistically significant difference was observed between the other groups in terms of surface hardness (p > .05). A controlled CHX release was achieved by mHAP and HAP nanocarriers for 120 days. The nanocarrier addition up to 5% did not negatively affect the DC and the surface hardness which is one of the surface properties of the resin composites. Although the addition of 5% nanocarrier to the resin composite increased the surface roughness, while adding 1% of these nanocarriers did not change.
Recent research progress of heterocyclic nematicidal active compounds
Authors: Wang Yu , Luo Xin , Chen Yifang , Peng Ju , Yi Chongfen , Chen Jixiang 
Published: December 2022

AbstractPlant‐parasitic nematodes cause huge economic losses of $ 157 billion to world agriculture annually. Long‐term use of traditional nematicides can lead to increased resistance of nematode and reduced control effectiveness. New effective and safe nematicides are needed to replace the organophosphorus and carbamate. Heterocyclic compounds play an important role in nematicide discovery. For example, the new nematicides fluenesulfone, fluopyram, cyclobutrifluram, tioxazafen, imicyafos, and fluazaindolizine have at least one heterocyclic ring in their structures. In view of the importance of heterocyclic structure in the development of nematicides, this paper reviews the research progress of nematicidal active compounds of heterocyclic in recent years, and discusses the structure–activity relationship (SAR) and mechanism of action. It is hoped that it can provide new inspiration for the development of new nematicides.
Chalcones: Versatile intermediates in heterocyclic synthesis
Authors: Nayak Yogeesha N. , Gaonkar Santosh L. , Sabu Mariya 
Published: December 2022

AbstractChalcones are a fascinating and well‐studied group of organic molecules. Synthesis of chalcones has been one of the essential areas of organic synthesis over the last few decades because of their immense therapeutic and excellent photophysical properties. Furthermore, these chalcone derivatives can be utilized to make a variety of heterocyclic compounds, especially five‐ and six‐membered heterocycles. Heterocyclic compounds have a long history in chemistry, primarily in pharmaceuticals. However, synthesizing some specific heterocyclic molecules remains challenging and requires multistep processes with few possible intermediates. Chalcones can be considered as one of the most useful, readily available intermediates in heterocyclic synthesis. Herein, the synthesis of various potential heterocyclic compounds using chalcones as an intermediate is elaborated. This review shows the untapped potential of chalcones in organic synthesis. Also, it will assist the chemist in designing new heterocycles by adopting these strategies.
Viruses responsible for acute respiratory infections before (2016–2019) and during (2021) circulation of the SARS‐CoV‐2 virus in pediatric patients in a reference center at Barranquilla Colombia: A pattern analysis
Authors: Zarur‐Torralvo Shiara , Stand‐Niño Iván , Flórez‐García Victor , Mendoza Humberto , Viana‐Cárdenas Erika 
Published: December 2022

AbstractObjectiveTo evaluate the behavior of the viruses responsible for acute respiratory infections before (2016–2019) and after (2020–2021) the start of the circulation of the SARS‐CoV‐2 virus in pediatric patients treated at a reference center from Barranquilla, Colombia.Materials and MethodsA descriptive observational study was carried out, and data were obtained by reviewing the influenza‐like illness and severe acute respiratory infection database in the pediatric population of the sentinel surveillance reference center in the district of Barranquilla during the years 2016–2021, applying inclusion and exclusion criteria.ResultsDuring 2016–2019, the average age of individuals was 1.3 (±1.7) years, during 2021, it was 2.3 (±3.5) years. The distribution by sex was similar, predominantly male. August and February were the months with the highest record of symptoms for 2016–2019 and 2021, respectively, the most frequent being cough, fever, shortness of breath, and diarrhea. By 2021 there was a higher use of antibiotics and antivirals reported than in 2016–2019. Most patients tested negative for viral detection. When comparing the percentage of viruses detected by age group and years of detection, positivity was lower in 2021 by every age group, and respiratory syncytial virus (RSV) was the most frequently detected.ConclusionsThere was less virus positivity in viral detection tests in the pediatric population in 2021. RSV persists as the main etiology affecting this population, especially infants. The use of antibiotic therapy in viral infections continues to be a problematic practice in their management. Sentinel surveillance can be strengthened throughout the country.
Characterization of cross‐reactive monoclonal antibodies against SARS‐CoV‐1 and SARS‐CoV‐2: Implication for rational design and development of pan‐sarbecovirus vaccines and neutralizing antibodies
Authors: Li Shibo , Wu Jianbo , Jiang Weiyu , He Haiyan , Zhou Yunjiao , Wu Wei , Gao Yidan , Xie Minxiang , Xia Anqi , He Jiaying , Zhang Qianqian , Han Yuru , Wang Nan , Zhu Guangqi , Wang Qiujing , Zhang Zheen , Mayer Christian T. , Wang Kang , Wang Xiangxi , Wang Junqing , Chen Zhenguo , Jiang Shibo , Sun Lei , Xia Rong , Wang Qiao 
Published: December 2022

AbstractEmergence of various circulating SARS‐CoV‐2 variants of concern (VOCs) promotes the identification of pan‐sarbecovirus vaccines and broadly neutralizing antibodies (bNAbs). Here, to characterize monoclonal antibodies cross‐reactive against both SARS‐CoV‐1 and SARS‐CoV‐2 and to search the criterion for bNAbs against all emerging SARS‐CoV‐2, we isolated several SARS‐CoV‐1‐cross‐reactive monoclonal antibodies (mAbs) from a wildtype SARS‐CoV‐2 convalescent donor. These antibodies showed broad binding capacity and cross‐neutralizing potency against various SARS‐CoV‐2 VOCs, including B.1.1.7 (Alpha), B.1.351 (Beta), P.1 (Gamma), and B.1.617.2 (Delta), but failed to efficiently neutralize Omicron variant and its sublineages. Structural analysis revealed how Omicron sublineages, but not other VOCs, efficiently evade an antibody family cross‐reactive against SARS‐CoV‐1 through their escape mutations. Further evaluation of a series of SARS‐CoV‐1/2‐cross‐reactive bNAbs showed a negative correlation between the neutralizing activities against SARS‐CoV‐1 and SARS‐CoV‐2 Omicron variant. Together, these results suggest the necessity of using cross‐neutralization against SARS‐CoV‐1 and SARS‐CoV‐2 Omicron as criteria for rational design and development of potent pan‐sarbecovirus vaccines and bNAbs.
Lattice vibrational modes in changchengite from Raman spectroscopy and first principles electronic structure
Authors: Chatterjee B. , Vengust D. , Mrzel A. , Sutar P. , Goreshnik E. , Mravlje J. , Mertelj T. 
Published: December 2022

AbstractWe measured room‐temperature phonon Raman spectra of changchengite (IrBiS) and compared the experimental phonon wavenumbers to the theoretical ones obtained by means of the ab initio density‐functional‐theory calculations in the presence and absence of the spin‐orbit coupling effects. Combining two different excitation photon energies all the symmetry predicted Raman modes are experimentally observed. The electronic properties of IrBiS are found to be similar to the recently studied isostructural compound IrBiSe showing a large Dresselhaus spin‐orbit valence band splitting. A good agreement between the experimental and theoretically predicted Raman phonon wavenumbers is found only when the lattice parameter is constrained to the experimental value. The inclusion of the spin orbit coupling does not significantly affect the phonon wavenumbers.
Development of non‐destructive models to predict oil content and fatty acid composition of Gomenzer (Ethiopian mustard) using near‐infrared reflectance spectroscopy
Authors: Tsegay Girmay , Ammare Yibrah , Tollassa Kassaye , Shiferaw Legesse 
Published: December 2022

AbstractBackground‟Gomenzer” or Ethiopian mustard is the potential oilseed crop that is economically important. Ethiopian mustard and rapeseed quality breeding has focused on altering the fatty acid contents of seed oil to create novel genotypes with different oil characteristics. The goal of this research was to establish calibration equations' using a method called near‐infrared reflectance spectroscopy with modified partial least squares (MPLS) regression.ResultThe spectra of 180 mustard samples were collected and their oil and fatty acid compositions were determined by n‐hexane extraction and GC–MS methods respectively. With 130 samples, calibration equations were developed for oil and fatty acid compositions. All developed equation had an acceptable value of R 2c, RPDc, and also had suitable 1‐VR values. Prediction of an external validation with 50 datasets revealed a blameless correlation between reference values and NIRS values based on the R 2v in prediction, SEP, and the ratio of SD to SEP (RPDv) for oil, oleic, linoleic, linolenic, and erucic acids. These had suitable values of RPDv and R 2v, with the range of 2.0 to 8.8 and 0.79 to 0.99 respectively.ConclusionThe developed models gave meaningful quantitative data, however, the equations generated for palmitic, stearic, and eicosenoic acids were insufficient for data analysis. Hence, the developed NIRS model, which was satisfactory, could be used to assess and evaluate the oil and fatty acid content for the unknown mustard samples on a regular basis in the oilseed breeding quality program.
Effects of microwave and conventional heating on physicochemical, digestive, and structural properties of debranched quinoa starch‐oleic acid complexes with different water addition
Authors: Li Jing , Wang Mengting , Liu Guangxin , Wang Wei , Hu Aijun , Zheng Jie 
Published: December 2022

AbstractBackgroundA starch‐lipid complex is a new type of resistant starch, which is of great importance for the prevention of chronic diseases such as diabetes. Most starch‐lipid complexes usually need to be treated by heating to make them suitable for a variety of applications, and starch‐based foods are generally not edible without a heat‐treatment process. However, the digestion and structural properties of the starch‐lipid complex will be changed after heating. In this study, microwave and conventional heating were used to treat debranched quinoa starch‐oleic acid complexes (DQS‐OA) with different water addition conditions, and the effects of the two methods on the physicochemical, digestive, and structural properties of DQS‐OA were compared.ResultsThe results of in vitro digestibility showed that the resistant starch content (235.34–269.55 g kg−1) of the conventional heating‐treated samples was significantly higher than that the microwave‐treated samples (141.51–157.99 g kg−1). Moreover, after microwave treatment, the short‐range molecular order and crystalline structure of DQS‐OA were destroyed and the particle size became smaller. In contrast, the thermal stability, enthalpy, and crystallinity of the complexes after conventional heating were improved. The ratio at 1047/1022 cm−1 of complexes has also been increased.ConclusionThis study demonstrated that conventional water‐bath heating was better than microwave heating in increasing digestion resistance, improving the short‐range and long‐range molecular order, and promoting the formation of DQS‐OA. With an increase in water addition, the influence of microwave or water‐bath treatment on the properties of DQS‐OA became greater. © 2022 Society of Chemical Industry.
Baseline ultrasound and FDG‐PET/CT imaging in Merkel cell carcinoma
Authors: Zijlker Lisanne P. , Bakker Max , van der Hiel Bernies , Bruining Annemarie , Klop W. Martin C. , Zuur Charlotte L. , Wouters Michel W. J. M. , van Akkooi Alexander C. J. 
Published: December 2022

AbstractBackgroundMerkel cell carcinoma (MCC) is a cutaneous tumor with a high tendency to metastasize, and a significant proportion of patients have metastases at first presentation. This study aims to determine the value of baseline ultrasound (US) and 18fluorodeoxyglucose‐positron emission tomography/computed tomography (18FDG‐PET/CT) imaging in both patients with clinically localized MCC (Stage I/II) and patients who present with palpable lymph nodes (Stage III).MethodsThis retrospective cohort included 135 MCC patients who underwent baseline US (with fine needle aspiration cytology (FNAC)) and/or FDG‐PET/CT imaging between 2015 and 2021.ResultsOf the 104 patients with clinically localized disease, 48% were upstaged to Stage III and 3% to Stage IV by imaging or sentinel lymph node biopsy (SLNB). FDG‐PET/CT imaging identified regional metastases in 23%, while US with FNAC identified regional metastases in 19%. SLNB was performed in 56 patients, of whom 57% were upstaged to Stage III. Of the 31 patients who presented with palpable lymph nodes, 16% were upstaged to Stage IV by FDG‐PET/CT imaging.ConclusionBaseline imaging frequently upstages Stage I/II MCC patients to Stage III, both by US and FDG‐PET/CT, Stage IV disease is rarely identified. Patients who present with palpable nodes are frequently upstaged to Stage IV by FDG‐PET/CT imaging.
Molecular dynamics study of corrosion behavior of iron with vacancies exposed to lead‐bismuth eutectic
Authors: Chen Li‐Ming , Xu Shuai , He Xiao‐Xun , Cao Qi‐Long , Li Bing‐Sheng 
Published: December 2022

AbstractThe corrosion behavior of iron with vacancies in a liquid lead‐bismuth eutectic environment is simulated by molecular dynamics with embedded‐atom model potential at 700–1073 K. The vacancy is substituted into Fe crystal with the percentage of 0%, 0.2%, 0.4%, 1.0%, and 2.0% to investigate the effect of the vacancy on the corrosion behavior of iron. By evaluating the time‐dependences of penetration depths and the number of penetrating Pb and Bi atoms and also observing the trajectory of a penetrating Bi atom, we concluded that temperature and vacancy will enhance the corrosion behavior of iron in liquid lead‐bismuth, and the corrosivity of Bi atom is larger than that of Pb atom. The result is supported by the calculated substitutional energies of each Pb or Bi atom with a Fe atom or vacancy, which are in the order of . If there are vacancies in the iron bulk, the Bi atom and Pb atom will preferentially penetrate the bulk through the vacancies, and the Bi atom has another way to penetrate into the bulk by substituting the Fe atom layer by layer. The present study provides new insight into challenges related to the corrosion behavior of iron‐based materials with vacancy‐type defects.
Laughing in the face of embarrassment: Humorous marketing messages, excitement, and embarrassing products in retail
Authors: Barney Christian , Jones Carol L. Esmark 
Published: December 2022

AbstractHumorous messages can influence consumers differently based on the type of product and context; this research seeks to determine how humorous versus informative messages differentially impact consumer's responses to embarrassing products versus nonembarrassing products in retail. This paper proposes that humorous messaging may be used to counteract negative responses to embarrassing products as opposed to much of the research on consumer embarrassment which focuses on coping mechanisms and reducing the noticeability of a product in retail settings. Specifically, marketers may use benign humor to increase excitement and ultimately increase purchase likelihood of a product. The researchers examine the process through which consumers view humorous marketing of embarrassing products. Three studies, including a behavioral lab experiment utilizing a 360° video choice experiment as well as a Facebook ads behavioral experiment, are used to assess the proposed relationship. The findings indicate that for embarrassing products, humorous messaging is more effective than informative messaging at increasing purchase likelihood due to an increase in excitement. These results hold across a variety of marketing mediums. This research suggests that practitioners should use humorous marketing communications rather than informative marketing communications for embarrassing products in retail.
Fluency and the perceived ethicality of corporate social (ir)responsibility
Authors: Grolleau Gilles , Mzoughi Naoufel , Wright Scott 
Published: December 2022

AbstractCorporate social responsibility (CSR) has remained a focus in business and society for decades. Existing research, however, has only begun to examine moral violations, or incidences of corporate social irresponsibility (CSI). In this article, we identify perceptual fluency—the ease with which information is processed—as an influential factor. Through three experiments, we reveal that individuals view incidences of CSI as less unethical when perceptual fluency is low (vs. high). This occurs because decreased perceptual fluency encourages deliberative processing, which impacts the perceived ethicality of CSI incidences. These results replicate across different countries, product categories, and CSI typologies. We also identify the type of corporate action as an important boundary condition; as perceptual fluency did not impact the perceived ethicality of analogous CSR incidences. We also find that the effect is influenced by the individual moral philosophy of the consumer, with the effect occurring only for those higher in moral relativism. Overall, these results empirically disentangle competing theoretical accounts linking perceptual fluency with moral judgment, and show that businesses and other parties should consider the fluency of CSI communications along with the moral philosophy of their customers and other stakeholders.