bluuebunny/crossref_metadata_2025_split huggingface dataset:
The impacts of tourism development on income inequality: how does tourism capital investment contribute to income distribution? Tourism Agenda 2030
Authors: Kumail Tafazal , Sadiq Muhammad , Ali Wajahat , Sadiq Farah 
Published: January 2023

Purpose
This study aims to analyze tourism development's (TOD) role in demoting income inequality in South Asia from 1996 to 2020. To this end, this study explored the connection between TOD, tourism investment, economic growth (GDP), trade globalization (TGL) and income inequality.

Design/methodology/approach
This study used various techniques, including cross-sectional dependence, unit root, cointegration techniques, long-term elasticity estimators and short-term causality between the study variables. This study adopted Driscoll–Kraay standard errors and Dumitrescu Hurlin panel causality estimations.

Findings
This study’s results reveal that tourism has an inverted U-shaped association with income inequality in the long run, which supports the Kuznets Curve hypothesis. In contrast, capital investment in tourism (CIT) has a significant negative association with income inequality. At the same time, growth and TGL positively and significantly affect income inequality. Moreover, TOD has a bidirectional feedback causality of income inequality. These results also support tourism's “price effect” on income inequality. Hence, this study provides more practical implications regarding policymaking in tourism and income inequality in developing economies to target Agenda 2030.

Originality/value
This study is unique by considering the cross-sectional dependence in estimating the model that has been ignored in previous studies and provides new insights into the existing literature by investigating how TOD and CIT contribute to income inequality concentrating on the understudied South Asian economies from 1996 to 2020. As a result, this study has more practical implications for policymaking in the tourism industry and income inequality in emerging economies.
Warmer temperatures result in maladaptive learning of sexual preferences
Authors: Holveck Marie‐Jeanne , Muller Doriane , Visser Bertanne , Timmermans Arthur , Colonval Lidwine , Jan Fabrice , Crucifix Michel , Nieberding Caroline M. 
Published: January 2023

Abstract

The impact of learning ability and sexual selection on the climate and biodiversity crisis is currently unclear.

Using the African butterfly Bicyclus anynana, which shows strong phenotypic plasticity (i.e., polyphenism) in response to temperature, we tested whether learning affects mate preferences under climate warming.

We first modelled climate warming scenarios and then showed experimentally that temperature becomes an unreliable cue to the onset of the dry season, adult butterflies displayed the wet season rather than the dry season form.

Experienced females that were exposed to different male seasonal phenotypes during sexual maturation changed sexual preferences.

Female fertilization success was reversed for naive compared with experienced females, likely reducing female fitness following climate warming.

Our results emphasize the importance of sexual selection, learning, and their fitness consequences for understanding (mal)adaptation of natural populations to climate warming.

Read the free Plain Language Summary for this article on the Journal blog.
Influence of nest box design on internal microclimate: Comparisons of plastic prototypes
Authors: Callan Michael N. , Johnson Alexander , Watson David M. 
Published: January 2023

AbstractHollow‐dependent fauna are declining worldwide, due primarily to the widespread clearing of hollow‐bearing trees. Artificial cavities such as timber and plywood boxes are commonly used to increase hollow availability, yet there is increasing evidence that they are poor facsimiles of natural cavities, characterized by lower insulative properties and a shorter field life. We evaluated whether plastic materials could create a nest box with a stable thermal profile that more closely resembles the complex shapes and textures of natural tree hollows while containing fewer mechanical joins that represent potential failure points when installed. We developed three sets of prototype nest boxes comprising various combinations of plastic density (10%, 25% and 50%), insulation (single vs. double wall with or without sawdust between them), nesting chamber (with or without timber inserts) and bedding (with or without decomposed heartwood) and compared their thermal performance in a temperature‐controlled laboratory to compare internal temperature and relative humidity. We found double‐walled plastic nest box with an internal timber‐lined chamber was best able to buffer ambient temperature fluctuations, consistently recording internal temperatures of 6+°C below maximum ambient temperature, maintaining high levels of relative humidity (76%–92%) when furnished with decomposed timber heartwood. This design also performed better during a simulated hot day; internal temperatures exhibiting twice the lag time of single‐walled designs, noting that plastic density had little influence on internal conditions. While the recruitment and protection of hollow‐bearing trees must be a priority, this work shows significant potential in improving the design and functionality of artificial hollows that are critical to the conservation of hollow‐dependent species.
Feasibility and safety of a robotic approach to diverticular disease: a retrospective series of short‐term outcomes
Authors: Bromley Luke , Huang Dora , Mohan Helen , Rajkomar Amrish , Larach José Tomas , Heriot Alexander , Smart Philip , Warrier Satish 
Published: January 2023

AbstractBackgroundsRobotic colorectal surgery is a method of performing complex surgery in a minimally invasive manner. In diverticular disease, chronic inflammation obscures tissues planes and increases difficulty of resection. This study aims to assess feasibility and safety of application of a robotic approach to diverticular disease, by reviewing short‐term outcomes from a series of diverticular resections.MethodsForty‐one patients underwent robotic colorectal surgery for diverticular disease across three centres within Melbourne from June 2016 to June 2022. Demographic, operative, and clinicopathological data were collected. Descriptive statistics were used to evaluate primary and secondary outcomes. Comparative analysis between simple and complex diverticular disease was performed to identify differences in groups regarding short term outcomes. The primary outcome in this study is to determine conversion rate from minimally invasive to open surgery. Secondary outcomes include major complication rates and length of stay.ResultsOf the 41 patients, 24 (58.5%) had simple disease, and 17 (41.5%) had complex disease. One patient (2.4%) required conversion to open resection. The median length of stay for complex disease was 7 days, for simple disease 5 days (P = 0.05). Four surgical Clavien‐Dindo III or above complications occurred (9.8%), one patient required return to theatre. There were no anastomotic leaks or collections requiring radiological drainage. Thirteen patients (31.7%) underwent ureteric stenting and intraoperative indocyanine green dye ureteric identification.ConclusionRobotic diverticular resections in this series are safe and associated with a low conversion rate of 2.4%. Robotic resection of complex disease was feasible with an acceptable safety profile.
Surgery for phyllodes tumour of the breast. What should be surgical margins?
Authors: Tukenmez Mustafa , Mollavelioglu Baran , Onder Semen , Emiroglu Selman , Velidedeoglu Mehmet , Ergun Sefa , Cabioglu Neslihan , Muslumanoglu Mahmut 
Published: January 2023

AbstractBackgroundsOptimal and tailored surgical treatment of phyllodes tumour(PT) of the breast is controversial. This study aims to determine the appropriate surgical margin in the treatment of PT.MethodologyThe data of 132 patients who underwent breast surgery with the diagnosis of PT at the Breast Unit of Istanbul Faculty of Medicine from 2000 to 2022 were retrospectively reviewed.ResultsMedian age was 38 and patients with benign PT were younger than others(median age was 34, 44, and 43 for benign, borderline, and malignant, respectively) (P = 0.001). Local recurrence was observed in 7 (5.3%) patients, systemic recurrence was observed in 3 (2.3%) patients, and disease‐related death was observed in 2 (1.5%) patients. Local recurrence occurred in 1.4% (n = 1) of benign tumours, 8.3% (n = 2) of borderline tumours, and 10.3% (n = 4) of malignant tumours. All of the systemic recurrences and deaths were seen in the malignant group. The local recurrence rate was found to be higher in borderline and malignant tumours with surgical margins less than 10 mm (44.4% versus 3.7%, P = 0.003), and tumours larger than 5 cm (11.8% versus 1.3%, P = 0.015). In comparison, there was no correlation between the surgical margin proximity, tumour diameter, and local recurrence rates in benign PT (P > 0.05).ConclusionAccording to our findings, negative surgical margins seem to be sufficient in the treatment of benign phyllodes tumours. Furthermore at least 1 cm negative surgical margins must be achieved for malignant and borderline phyllodes tumours to avoid local recurrence.
Productivity drivers of infrastructure companies: Network industries utilizing economies of scale in the digital era
Authors: Nakatani Ryota 
Published: January 2023

AbstractWhat drives the productivity dynamics of infrastructure companies? Using a panel of firms in 14 countries, we study total factor productivity (TFP) enhancers of utility and network services companies. We find that moving TFP closer to the technological frontier drives productivity growth at higher speeds in Asian countries than in European countries. We also find that financial leverage exerts a positive effect on TFP growth for larger infrastructure firms and that more financially developed countries utilize economies of scale through better use of financial resources. Large utility and transportation companies display a higher rate of TFP growth, indicating that a competition policy to encourage M&As would be prudent for the utility/transportation sectors to maximize economies of scale. In contrast, we find diseconomies of scale for energy companies in some countries. Moreover, young network firms improve TFP growth faster than their peers in countries with fewer product market regulations. Therefore, policies should remove entry barriers while facilitating the departure of old and low‐productivity firms from network markets. Finally, policymakers should offer well‐targeted fiscal incentives for intangible investments to boost TFP because the accumulation of intangible assets such as digital technology promotes more scale economies through network effects.
Horizontal pay dispersion as social context for predicting employee performance outcomes associated with diagnostic‐ versus criterion‐referenced performance feedback
Authors: Bachrach Daniel G. , Naskar Shankar T. , Patel Pankaj C. , Levy Paul 
Published: January 2023

AbstractDespite its recognised centrality as an organisational tool, there are decades of mixed findings relating to the employee performance benefits associated with different forms of performance feedback. The ambiguity present in the literature has been attributed to multiple factors, including feedback purpose and the context within which feedback occurs. Integrating these broad themes, we develop a model expanding the breadth of relevant social context variables to include horizontal pay dispersion. Building from tournament theory, in a field experiment of 267 employees across 22 units, we find improved performance from diagnostic feedback delivered under increasing pay dispersion; however, substantively different patterns emerge for criterion‐referenced feedback. The current findings have implications for both performance feedback research and tournament theory.
Metabolic adaptations of cancer in extreme tumor microenvironments
Authors: Nakahara Ryuichi , Maeda Keisuke , Aki Sho , Osawa Tsuyoshi 
Published: January 2023

AbstractCancer cells are highly heterogeneous to adapt to extreme tumor microenvironments (TMEs). TMEs challenge cancer cells via hypoxia, nutrition starvation, and acidic pH, promoting invasion and metastasis concomitant with genetic, epigenetic, and metabolic alterations. Metabolic adaptation to an extreme TME could allow cancer cells to evade cell death and immune responses, as well as resulting in drug resistance, recurrence, and poor patient prognosis. Therefore, elucidation of the metabolic adaptation of malignant cancer cells within TMEs is necessary, however, most are still elusive. Recently, adaptation of cancer cells within the TME can be analyzed via cell–cell interactions at the single‐cell level. In addition, information into organelle–organelle interactions has recently been obtained. These cell–cell, and organelle–organelle interactions demonstrate the potential as new cancer therapy targets, as they play essential roles in the metabolic adaptation of cancer cells to the TME. In this manuscript, we review (1) metabolic adaptations within tumor microenvironments through (2) cell‐to‐cell, and (3) organelle–organelle metabolic interactions.
Strain matters in mouse models of peanut‐allergic anaphylaxis: Systemic IgE‐dependent and Ara h 2‐dominant sensitization in C3H mice
Authors: Paolucci Marta , Homère Valentine , Waeckerle‐Men Ying , Wuillemin Natascha , Bieli Dimitri , Pengo Niccolò , Sonati Tiziana , Kündig Thomas M. , Johansen Pål 
Published: January 2023

AbstractBackgroundPeanut allergy accounts for the majority of food‐induced hypersensitivity reactions and can lead to lethal anaphylaxis. Animal models can provide an insight into the immune mechanisms responsible for sensitization and allergic anaphylaxis. However, different mouse strains and sensitization protocols can influence the successful development of a peanut allergic mouse model.ObjectiveWe aimed at developing a systemic anaphylaxis model of peanut allergy that resembles human anaphylaxis. We compared the immunological and clinical responses in genetically different mouse strains.MethodsFemale BALB/c, C57BL/6, and C3H mice were intraperitoneally sensitized and later challenged with peanut proteins. Allergen‐specific serology was done by ELISA, and anaphylaxis was evaluated by monitoring changes in body temperature upon systemic challenge.ResultsSensitization to peanut was successful in C3H mice and triggered production of allergen‐specific antibodies, cytokines and anaphylaxis. Allergic reactions were characterized by the release of allergic mediators and by changes in leukocyte populations in blood and in the peritoneal cavity. Among the identified major peanut allergens, Ara h 2 showed the strongest anaphylactic potential. Much lower or no trigger of peanut‐specific antibodies was observed in BALB/c and C57BL/6 mice, which experienced no hypersensitivity reactions.ConclusionsMouse strain matters for testing of peanut protein allergens. We identified C3H mice as a suitable strain for the development of a mouse model of peanut‐allergic anaphylaxis. Pre‐clinical, humoural and cellular responses resembled the responses observed in human patients. The described model can be useful for further studies on peanut allergy and for the development of new therapeutic strategies.
Deproteinized bovine bone and freeze‐dried bone allograft in sinus floor augmentation: A randomized controlled trial
Authors: Kungvarnchaikul Isaya , Subbalekha Keskanya , Sindhavajiva Pimrumpai R. , Suwanwela Jaijam 
Published: January 2023

AbstractPurposeThe aim of this study was to investigate the effects of deproteinized bovine bone (DBB, Bio‐Oss®) and freeze‐dried bone allograft (FDBA, SureOss®) on bone healing during maxillary sinus floor augmentation (MSFA) using histology, immunohistochemistry, and gene expressions of the marker genes including Runx2, Opn, Ocn, Col1a1, Rankl, and Tnf‐α.Materials and MethodsFourteen participants who required two‐stage maxillary sinus augmentation were randomly assigned to DBB and FDBA bone grafting groups. Six months after the sinus augmentation procedure, bone samples were collected before implant placement with a trephine bur. Gene expression of Runx2, Opn, Ocn, Col1a1, Rankl, and Tnf‐α of the bone samples was assessed by real‐time polymerase chain reaction as a primary outcome. Histological analysis of H&E‐stained sections, immunohistochemistry for OPN quantification, and CBCT‐based bone tissue examination were performed to investigate the bone healing effects of DBB and FDBA substitutes.ResultsThe FDBA treated group showed higher gene expression when compared with the DBB treated group in Opn (2.83 ± 1.23 vs. 1.40 ± 0.69; p = 0.04), Runx2 (1.49 ± 0.44 vs. 0.67 ± 0.14; p = 0.01), and Rankl (2.34 ± 0.85 vs. 0.69 ± 0.39; p = 0.03). In the DBB treated group a downregulated expression was found of Ocn relative to maxillary edentulous bone (1.18 ± 0.40 vs. 2.51 ± 0.78; p = 0.02).ConclusionTwo‐stage maxillary sinus augmentation with FDBA upregulated specific bone remodeling genes when compared to DBB. The outcome of gene expression matched with the ones for OPN immunoreactivity, being higher in the FDBA group. FDBA had an expression pattern similar to native bone and showed stronger expression of bone forming related‐genes suggesting it may be clinically preferable over DBB.This clinical trial was not registered prior to participant recruitment and randomization (clinical registration number TCTR20221217002).
Fecal microbiota transplantation and short‐chain fatty acids protected against cognitive dysfunction in a rat model of chronic cerebral hypoperfusion
Authors: Su Shao‐Hua , Chen Ming , Wu Yi‐Fang , Lin Qi , Wang Da‐Peng , Sun Jun , Hai Jian 
Published: January 2023

AbstractAimsClear roles and mechanisms in explaining gut microbial dysbiosis and microbial metabolites short‐chain fatty acids (SCFAs) alterations in chronic cerebral ischemic pathogenesis have yet to be explored. In this study, we investigated chronic cerebral hypoperfusion (CCH)‐induced gut microbiota and metabolic profiles of SCFAs as well as the effects and mechanisms of fecal microbiota transplantation (FMT) and SCFAs treatment on CCH‐induced hippocampal neuronal injury.MethodsBilateral common carotid artery occlusion (BCCAo) was used to establish the CCH model. Gut microbiota and SCFAs profiles in feces and hippocampus were evaluated by 16S ribosomal RNA sequencing and gas chromatography–mass spectrometry. RNA sequencing analysis was performed in hippocampal tissues. The potential molecular pathways and differential genes were verified through western blot, immunoprecipitation, immunofluorescence, and ELISA. Cognitive function was assessed via the Morris water maze test. Ultrastructures of mitochondria and synapses were tested through a transmission electron microscope.ResultsChronic cerebral hypoperfusion induced decreased fecal acetic and propionic acid and reduced hippocampal acetic acid, which were reversed after FMT and SCFAs administration by changing fecal microbial community structure and compositions. Furthermore, in the hippocampus, FMT and SCFAs replenishment exerted anti‐neuroinflammatory effects through inhibiting microglial and astrocytic activation as well as switching microglial phenotype from M1 toward M2. Moreover, FMT and SCFAs treatment alleviated neuronal loss and microglia‐mediated synaptic loss and maintained the normal process of synaptic vesicle fusion and release, resulting in the improvement of synaptic plasticity. In addition, FMT and SCFAs supplement prevented oxidative phosphorylation dysfunction via mitochondrial metabolic reprogramming. The above effects of FMT and SCFAs treatment led to the inhibition of CCH‐induced cognitive impairment.ConclusionOur findings highlight FMT and SCFAs replenishment would be the feasible gut microbiota‐based strategy to mitigate chronic cerebral ischemia‐induced neuronal injury.
Performing Vegetable Nutrition: Rethinking School Food and Health
Authors: Trapp Micah M. 
Published: January 2023

AbstractSchool food programs across the United States are plagued by widespread criticism and face urgent calls for reform and public discourse has also become fixated upon “healthy” eating as a means to address a variety of child health problems. Scholars widely challenge the admonishment to eat “healthy” as laden with privilege and recognize the inherent, hegemonic whiteness of contemporary alternative food movements, but few studies have directly examined the relationship between race and school food programs. This paper draws on ethnographic research to unpack “healthy eating” through the perspective of elementary school students and shows how they challenge dominant narratives that assume kids do not like vegetables and expose the fallacy of nutrition education as the key to healthy eating. Through the performance of vegetable nutrition, kids critically engage with normative nutrition messages and begin to reveal a racialized consciousness of school food.
CERS6 antisense RNA 1 promotes colon cancer via upregulating mitochondrial calcium uniporter
Authors: Yu Juan , Chen Xiaoguang , Li Jing , Wang Furang 
Published: January 2023

AbstractBackgroundColon cancer (CC) belongs to a common cancer of digestive system. Long non‐coding RNAs (lncRNAs) are dysregulated in numerous cancers and affect their development. The function of lncRNA CERS6 antisense RNA 1 (CERS6‐AS1) in CC remains unclear.Materials and MethodsCERS6‐AS1 expression in colon adenocarcinoma tissues and CC cell lines was assessed by The Cancer Genome Atlas database and quantitative real‐time polymerase chain reaction analysis. The function of CERS6‐AS1 in CC was analysed by 5‐ethynyl‐2′‐deoxyuridine, colony formation, flow cytometry, terminal deoxynucleotidyl transferase dUTP nick end labelling, wound healing, Transwell and immunofluorescence assays. Mechanistic analyses including RNA pull down, RNA‐binding protein immunoprecipitation and luciferase reporter assay revealed the interaction between RNAs.ResultsCERS6‐AS1 expression was aberrantly upregulated in colon adenocarcinoma tissues and CC cell lines. CERS6‐AS1 knockdown inhibited CC cell malignant phenotypes and in vivo tumour growth. CERS6‐AS1 served as the competing endogenous RNA of microRNA‐16‐5p in CC, and microRNA‐16‐5p inhibition partly rescued the effects of CERS6‐AS1 depletion on CC development. Mitochondrial calcium uniporter was targeted by microRNA‐16‐5p. Mitochondrial calcium uniporter upregulation completely remedied the influence of CERS6‐AS1 silencing in CC progression. Moreover, CERS6‐AS1 enhanced the stability of mitochondrial calcium uniporter messenger RNA via recruiting RNA‐binding protein embryonic lethal abnormal vision like 1.ConclusionCERS6‐AS1 promotes the development of CC via upregulating mitochondrial calcium uniporter expression.