bluuebunny/crossref_metadata_2025_split huggingface dataset:
Corneal Manifestation in Patients with Infantile Nephropathic Cystinosis
Authors: Kruse Franziska , Keidel Leonie Franziska , Priglinger Siegfried , Luft Nikolaus , Priglinger Claudia 
Published: January 2023

AbstractNephropathic cystinosis is a rare autosomal recessive disease caused by mutations in the CTNS gene. This causes dysfunction of cystinosin, a protein that transports cystine out of
lysosomes, causing cystine crystals to accumulate in cells in most organ systems. While renal complications predominate in the early forms of cystinosis, corneal crystal accumulation will
inevitably manifest in all patients. The main symptoms are photophobia along with glare sensitivity and blepharospasm. In addition, corneal crystal accumulation can cause other
complications, such as recurrent corneal erosions, punctate or filamentary keratopathy, and chronic dry eye. Eventually, peripheral corneal neovascularization and limbal stem cell deficiency
may develop. Ophthalmologists play a key role in the early diagnosis of patients with cystinosis. This review aims to not only raise awareness of secondary complications of corneal crystal
accumulation, but also to highlight current treatment options and challenges that ophthalmologists and pediatricians might face.
Heat transfer of copper mesh–powder composite-based sintered-wick vapor chamber
Authors: Zhao Zhengang , Li Lei , Wang Yuyuan , Wang Yaxin , Hui Yueyao 
Published: January 2023

With the rapid spread of high-power density equipment, the vapor chamber must adapt to more applicable environments and exhibit a better heat transfer performance. The copper mesh and powder are sintered in this work to make a composite wick vapor chamber (CW-VC). Six sections of copper wire are cut and sintered together with the wick as the inner support column of the CW-VC. The effects of filling ratio and inclination on the heat transfer performance of the vapor chamber are investigated. The experimental results showed that the maximum thermal power of the CW-VC is 23.29 W at the optimal liquid filling ratio of 80% and the lowest thermal resistance is 0.33 °C/W. Below the liquid filling ratio of 60%, when the inclination angle of the CW-VC increases, its thermal resistance increases. At filling ratios of 70%, 80%, and 90%, the inclination angle of 30° can reduce the thermal resistance of the CW-VC. It implies that the inclination angle of the CW-VC can be increased appropriately to reduce the thermal resistance when the filling ratio is high. However, when the liquid filling ratio is low, increasing the inclination angle of the CW-VC will make the liquid film of the evaporator thinner and dry out earlier and its thermal resistance will increase.
Agronomic performance of F7 soybean lines resistant to Soybean mosaic virus in the dryland area
Authors: Andayanie Wuye R. , Adinurani Praptiningsih G. , Lukito Martin , Pulihasih Akas Y. 
Published: January 2023

AbstractIn Indonesia, soybean cultivation is generally planted in paddy fields after the rice harvest. However, expanding soybean cultivation is needed to make optimal dry land in the future. This study aims to obtain F7 soybean lines resistant toSoybean mosaic virus(SMV) adaptive in the dry land. In the dry land planted eleven soybean breeding lines resistant to SMV and two varieties as control. Ten days after planting (DAP), soybean plants were inoculated with SMV. The experiment was conducted in the randomized complete block design with four replicates within each area. These results showed that the GK/PI200.485-7-17 line was the most superior soybean line and the potency to develop in the dryland area because it had the highest number of branches per plant, number of filled pods per plant, and 100-seed weight. The tested line showed the highest seed yields of 2.40 t/ha, and 2.72 t/ha, in Girisubo and Sidowayah Districts, respectively. This line did not indicate any serological relationship to SMV in both locations.
Is Long-term Cassava-based Agriculture Sustainable? (Case Study of Potassium Content in the Soil)
Authors: Setyastika Ursulin Sacer , Utami Sri Rahayu , Kurniawan Syahrul , Agustina Christanti 
Published: January 2023

Abstract
Farmer’s interest in planting cassava is relatively high because cassava is one of tolerant commodities toward drought, and low soil fertility. With minimum input, cassava still grow and produce. However, cassava absorb greater nutrients, especially potassium (K), leading to the depletion of essential nutrient availability. This research was carried out in Pati, Central Java, aimed to determine K nutrients status in the soil at the various durations of cassava land use. The research consisted of two factors, i.e 1) duration under cassava (five years, 10 yr, and 15 yr), and 2) slope (8 to 15% and 15 to 40%), each repeated four times. Soil and plant samples were taken at each location to determine K nutrients in the soil and plant (at harvest). Exchangeable K varies from low to moderate content, i.e. 0.44 to 0.50 cmol/kg (slope 1) and 0.22 cmol/kg (slope 2). Cassava land use showed an imbalance between input (fertilizer) and output (crop harvest) with negative results in the range of 114.59 to 524.78 kg K/ha. Exchangeable K content in the soils decreased with increasing K imbalance, meaning the longer period under cassava could lead to impoverishment of nutrients. Nutrient input should be increased to reduce the nutrient imbalance on the cassava farming system.
Development Model for Sustainable Utilization of Among Tani Application (A Study in Batu Smart City)
Authors: Fibrianingtyas Alia , Pertiwi Vi’in Ayu , Rayesa Neza Fadia 
Published: January 2023

Abstract
The extention in the industrial revolution 4.0 greatly changes and affect in disemination of information methods that should be delivered to farmers toward more dynamic [1]. Information and communication technology in agricultural development requires a certain educational process and capacity building due to some technical difficulties and lack of skills to implement it [4]. In Batu City, the older farmers can not get the beneficial from smart city concepts. They difficult to use the Among Tani application. So, this research important to design the development model scenario for sustainable use of Among Tani Application in Batu City. This research use qualitative method. The data were collected from indepth interview and complemented with secondary data. These data analyzed by descriptive method. The results of this research describe about the stakeholder role in accompaniment utilization of Among Tani and it obstacles. Beside that, the development model to made it sustain were created. So, it can be conclude that the job description of farmer facilitator ought to added, especially to help the digital marketing process for farmers.
The Decreasing Interest of Farmers in Soybean Farming in Puger Sub-District Jember Regency
Authors: Fauzi Nurul Fathiyah , Andriyani Sisi Dwi , Utami Aisyah Yuristianti 
Published: January 2023

Abstract
Puger Subdistrict is a soybean producer in Jember Regency, where the amount of production in the last three years has decreased drastically. In 2017 the soybean production in Puger sub-district reached 53 tons, in 2018 it fell to 508 quintals, and in 2019 it fell to 39 quintals. The decline in soybean production will threaten food security. It is also known that based on statistical data, Puger has decreased the area of soybean harvested, from 201 to 14 hectares ectara during the 2018-2019 period. The objectives of this study are to 1) identify the factors that influence the decrease in farmers ‘interest in doing soybean farming in Puger, and 2) provide alternative strategies that can be used to increase farmers’ interest in soybean farming in Puger. The research methods are descriptive, Multiple Linier Regression, and Force Field Analysis (FFA) with incidental sampling (45 people and 3 expert respondents). This research used primary and secondary data. The results showed that 1) The factor that had a significant effect on reducing farmers’ interest in soybean farming was the price of soybeans (Rp/kilo), while the price of corn (Rp/kilo) and the weather factor did not have a significant effect, 2) the alternative strategies are: increasing the selling price of soybeans at the farmer level, training from extension agents to farmers to increase the ability of farmers in doing soybean farming, especially related to technical matters, and strengthening central government policies stabilization of local soybean prices as an incentive to foster farmers’ interest in planting soybeans which will have an impact on increasing the amount of local soybean production that can meet market needs and reduce the number of soybean imports.
Evaluation of the Success of Forest Land Based on Geographic Information Systems, in Wonosalam District, Jombang Regency
Authors: Maroeto  , Rossyda P. , Idhom Mohammad , Santoso Wahyu , Siswanto  
Published: January 2023

Abstract
The benefits of forests for life are not only for local communities living around forests, but also for global communities whose lives depend on forests as a resource that is able to provide various functions related to environmental management. The research aims to identify the potential of the Wonosalam forest area planned for UPN Integrated Farming & Forestry Tourism (UIFFT) - KHDTK Wonosalam in support of conservation policies by mapping forest areas based on land suitability characteristics and land availability suitable for KHDTK development. This type of research is survey research. and spatial analysis using Geographic Information Systems. Location in this research was conducted in the Wonosalam Forest Area in Wonosalam District. Wonosalam District is located in Jombang Regency with an area of 121.63 km2. The results of the study can be concluded that 1. the results of the survey of regional characteristics and physical and chemical analysis of the soil for durian, clove and coffee plants have land suitability classes that are actually in accordance with marginal (S3eh) with a limiting factor on erosion hazard while for potential after experiencing improvements that are not overall permanent value obtained is quite appropriate (S2) with various limiting factors but most of the constraints on erosion hazard and land preparation. 2. The direction of forest area development in future research areas based on land suitability is an integrated farming forestry area with a technological approach, and plant suitability so that this area can become a center for research, innovation, education, training, empowerment and community assistance without compromising its function. forests as environmental conservationists in an integrated manner.
Generation of various vortex beams based on transformation materials
Authors: Lai Yunyun , Dong Wenxiu , Hu Jin 
Published: January 2023

Abstract
A flexible vortex beam generator (VBG) is proposed based on transformation optics (TO) to convert input plane waves to various output vortex beams. The methodology is a geometrical one based on the topological equivalence between the vortex beam cross section disc and a belt, turning the in-plane curvilinear distributed phase or polarization structures in the disc to be redistributed around the belt. Consequently, abundant vortex beams can be exported by simply configuring the incidence angles and polarization directions of the plane waves. The topology and wave propagation characteristics behind the system are investigated, and TO is used to obtain the desired materials by adopting a specific space mapping. Some sample numerical simulations are described to verify the feasibility of the proposed design, including several complex orbital angular momentum and cylindrical vector beams. Due to its flexibility and simplicity, the proposed VBG is likely to have extensive application prospects.
Measures of weak non-compactness in 𝐿₁(𝜇)-spaces
Authors: Chen Dongyang 
Published: January 2023

Disjoint sequence methods from the theory of Riesz spaces are used to study measures of weak non-compactness in

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for every norm bounded subset

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313 Assessment of racial differences of atopic dermatitis characteristics in a diverse outpatient cohort in the United States
Authors: Sanfilippo Eric , Iyer Sneha , Patel Nisha , Silverberg Jonathan I 
Published: January 2023

Abstract
Atopic dermatitis (AD) can present differently across racial groups. To promote equality and consistency, dermatologists and other providers should properly recognize the heterogeneous manifestations of AD across racial groups. Yet, little is known about differences in how the commonly different features of AD occur by race. We assessed racial differences in the proportions of select key features of AD. The healthcare claims database from a large metropolitan tertiary care medical centre was queried for patients with physician-diagnosed AD using International Classification of Disease, Tenth Revision and Clinical Modification codes L20.x. Medical records were reviewed for demographics, comorbidities and documentation of Hanifin-Rajka criteria. The frequency of each criterion was evaluated by race (White, Black, Asian and Multiracial–Other). Overall, 766 patients with AD were included in the study; 374 (48.8%) were White, 284 (37.1%) Black, 89 (11.6%) Asian and 19 (2.5%) multiracial/other, 558 (68.2%) were female, 50 (6.1%) were age &lt;18 years, 456 (55.7%) age 18–49 years and 313 (38.2%) age ≥50 years. Compared to White patients, Black patients had significantly higher proportions of personal (81.4% vs. 57.3%) and family (63.3% vs. 42.2%) history of atopic disease, perifollicular accentuation (60.6% vs. 36.9%) and xerosis on physical exam (84.2% vs. 73.9%)(P ≤ 0.03 for all). Multiracial/other patients had elevated proportions of a history of dry skin (81.3%), xerosis on physical exam (86.7%) and elevated Immunoglobulin E levels (75.0%). Black and multiracial/other patients had food hypersensitivity compared to White patients (50.0% and 71.4% vs. 35.1%, P = 0.04). There were marginally significant differences in the proportion of early-age AD onset (56.9% vs. 41.8%, P = 0.07) and anterior neck fold involvement (42.6% vs. 25.3%, P = 0.06) in Asian compared to White patients. There were no significant racial differences in the likelihood of other Hanifin-Rajka criteria, including pruritus, flexural dermatitis, chronic dermatitis, ichthyosis, nipple eczema, hand/foot dermatitis, immediate skin reactivity, subcapsular cataracts, cutaneous infections, pruritus when sweating, intolerance to wool/lipid solvents, environmental/emotional factors worsening AD, or white dermatographism. Our results suggest there are racial differences in AD characteristics even within a single region. These differences may be attributable to population-differences in genetics, environmental exposures, skincare practices etc. Future research is needed to understand the mechanisms and treatment responses of these heterogeneous AD presentations.
336 Efficacy of dupilumab in infants and preschoolers with atopic dermatitis up to 1 year
Authors: Paller Amy S , Siegfried Elaine C , Xiao Jing , Prescilla Randy , Bansal Ashish 
Published: January 2023

Abstract
Continuous use of several traditional systemic atopic dermatitis (AD) treatments in pediatric patients is not recommended due to safety concerns and lack of long-term efficacy data. Children aged 6 months to 5 years with moderate-to-severe AD who had participated in the 16-week, double-blind, phase 3 LIBERTY AD PRESCHOOL trial (NCT03346434, part B; parent study) were enrolled in an open-label extension (OLE) study (NCT02612454). Patients received subcutaneous dupilumab every 4 weeks (200 mg for children weighing 5 to &lt;15 kg; 300 mg for 15 to &lt;30 kg). Topical AD treatments were allowed. Relative to the parent study baseline, mean percentage changes (± standard error) in Eczema Area and Severity Index score were −41.6 (±4.6) and −54.0 (±3.2) at OLE baseline, −74.5 (±3.7) and −81.7 (±1.8) at week 16, and −85.6 (±3.5) and −86.4 (±2.2) at week 52 in the 200 and 300 mg dupilumab groups, respectively. The number of patients (%) achieving an Investigator’s Global Assessment score of 0/1 increased from OLE baseline (6/61 [9.8%] and 15/116 [12.9%]) to week 16 (22/58 [37.9%] and 35/115 [30.4%]), and at week 52 (16/34 [47.1%] and 18/54 [33.3%]) in the 200 and 300 mg dupilumab groups, respectively. The overall safety of dupilumab treatment administered for up to 1 year was consistent with the known dupilumab safety profile. Dupilumab treatment for 1 year provides sustained improvement in signs of AD in patients aged 6 months to 5 years with moderate-to-severe AD.
The motor system is exceptionally vulnerable to absence of the ubiquitously expressed superoxide dismutase-1
Authors: Park Julien H , Nordström Ulrika , Tsiakas Konstantinos , Keskin Isil , Elpers Christiane , Mannil Manoj , Heller Raoul , Nolan Melinda , Alburaiky Salam , Zetterström Per , Hempel Maja , Schara-Schmidt Ulrike , Biskup Saskia , Steinacker Petra , Otto Markus , Weishaupt Jochen , Hahn Andreas , Santer René , Marquardt Thorsten , Marklund Stefan L , Andersen Peter M 
Published: January 2023

Abstract
Superoxide dismutase-1 is a ubiquitously expressed antioxidant enzyme. Mutations in SOD1 can cause amyotrophic lateral sclerosis, probably via a toxic gain-of-function involving protein aggregation and prion-like mechanisms. Recently, homozygosity for loss-of-function mutations in SOD1 has been reported in patients presenting with infantile-onset motor neuron disease. We explored the bodily effects of superoxide dismutase-1 enzymatic deficiency in eight children homozygous for the p.C112Wfs*11 truncating mutation. In addition to physical and imaging examinations, we collected blood, urine and skin fibroblast samples. We used a comprehensive panel of clinically established analyses to assess organ function and analysed oxidative stress markers, antioxidant compounds, and the characteristics of the mutant Superoxide dismutase-1. From around 8 months of age, all patients exhibited progressive signs of both upper and lower motor neuron dysfunction, cerebellar, brain stem, and frontal lobe atrophy and elevated plasma neurofilament concentration indicating ongoing axonal damage. The disease progression seemed to slow down over the following years. The p.C112Wfs*11 gene product is unstable, rapidly degraded and no aggregates were found in fibroblast. Most laboratory tests indicated normal organ integrity and only a few modest deviations were found. The patients displayed anaemia with shortened survival of erythrocytes containing decreased levels of reduced glutathione. A variety of other antioxidants and oxidant damage markers were within normal range. In conclusion, non-neuronal organs in humans show a remarkable tolerance to absence of Superoxide dismutase-1 enzymatic activity. The study highlights the enigmatic specific vulnerability of the motor system to both gain-of-function mutations in SOD1 and loss of the enzyme as in the here depicted infantile superoxide dismutase-1 deficiency syndrome.
The impacts of hypoxia-inducible factor stabilizers on laboratory parameters and clinical outcomes in chronic kidney disease patients with renal anemia: a systematic review and meta-analysis
Authors: Takkavatakarn Kullaya , Thammathiwat Theerachai , Phannajit Jeerath , Katavetin Pisut , Praditpornsilpa Kearkiat , Eiam-Ong Somchai , Susantitaphong Paweena 
Published: January 2023

ABSTRACT
Renal anemia in chronic kidney disease (CKD) is associated with poor outcomes. Hypoxia-inducible factor (HIF) stabilizer, which induces endogenous erythropoietin synthesis and enhances iron mobilization, is a novel treatment for anemia in CKD. We conducted a systematic review and meta-analysis to analyze the effect of HIF stabilizers in anemic CKD patients. This meta-analysis included 43 officially published articles and 3 unpublished studies (27 338 patients). HIF stabilizer treatment significantly increased hemoglobin (Hb) level when compared with placebo (mean difference 1.19 g/dL; 95% confidence interval 0.94 to 1.44 g/dL; P &lt; .001). There was no significant difference in Hb level when compared with erythropoiesis-stimulating agents (ESAs). Significant reductions of ferritin and transferrin saturation (TSAT) were observed, while total iron-binding capacity was increased in the HIF stabilizer group compared with placebo or ESAs. HIF stabilizers significantly reduced hepcidin, high-density lipoprotein, low-density lipoprotein and triglyceride levels. Acute kidney injury and thrombotic events were significantly observed in patients receiving HIF stabilizers. There were no significant differences in myocardial infarction, stroke, dialysis initiation, pulmonary hypertension and mortality between HIF stabilizer and control groups. The present meta-analysis provided evidence that HIF stabilizers increased Hb and TIBC levels and reduced hepcidin, ferritin and TSAT in CKD patients with renal anemia. Long-term follow-up studies on clinical outcomes of HIF stabilizers are still needed.