bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relation of hydrological pulse to sediment stratigraphy in the Ayapel Flood Plain Lake, Colombia
Authors: Rúa Alex , Palacio Baena Jaime , Flórez Molina María Teresa 
Published: September 2023

The hydrological pulse and matter transfer between tributaries and wetlands link terrestrial and rheotrophic environments. The water-sediment interaction on multidecadal scale within wetlands of Colombian Atlantic savannahs remains greatly unknown. This study stratigraphically correlated nine sediment cores (13-30 cm) spanning ca. 110-600 years BP from the Ayapel Flood Plain Lake (AFPL). These correlations framed (i) zones of high anthropogenic pressure, (ii) main hydrodynamics, and (iii) organic matter (OM) contributions. More than 84% out of the 150 km2-extension of the AFPL was comprised of oxic mineral sediment that is object to early diagenesis. In contrast, methanogenesis was evinced by reduced sediment of anaerobic strata in adjacent marshes. The intensity of the hydrological pulse matched the stratified deposit of the rhizome from Eichhornia crassipes. Whereas sand and gravel were deposited under turbulent flow near the Quebradona tributary, clayish silt deposited at pelagic zones and sandy silt at waterways. The wind drag on the shallow-water surface enhanced resuspension and transport of the sediment that was originally contributed by fluvial inputs. Thus, relatively slow net sedimentation rates were proposed at Quebradona’s mouth (ca. 0.15 cm a-1), channels (ca. 0.1 cm a-1) and temporal marshes (ca. 0.05 cm a-1). In addition, the sediment of the AFPL exported the degradation products of the OM to the lower reaches of the San Jorge River and the atmosphere.
comparative study between Piecewise-Linear and Point-Based methodologies for galvanometer mirror systems
Authors: Jiménez-Fernández Victor Manuel , Cerecedo-Núñez Héctor H. , Padilla-Sosa Patricia , Beltrán-Parrazal Luis , Vazquez-Leal Hector , Filobello-Niño Uriel 
Published: September 2023

Galvanometer mirror systems are a fundamental tool used in many research fields to deploy curves over virtually any surface. Even though the point-based methodology is the current standard used to achieve this task, it has the shortcoming of using a format of coordinates (expressed as a massive list of points) to represent the curve to be displayed, requiring large memory arrays. An alternative methodology is the so-called Piecewise-Linear which representation format is based on the use of a mathematical Piecewise-Linear formulation where the curves to be drawn are treated as a parametric system composed of two positional equations, X and Y, related to each other by an artificial parameter \mu. In comparison against the point-based method, Piecewise-Linear exhibits attractive advantages such as: memory saving and improved sharpness for projected curves.
Preliminary
Authors: García Aristizábal Edwin Fabián 
Published: September 2023

Revista Facultad de Ingeniería is a journal that started its official publication in 1984. Since then, it is aimed to contribute to the diffusion of knowledge within the national and international academic community throughout the publication of high-quality research results. The Journal focuses on original works which mainly include experimental studies, numerical analyses, case studies, and bibbliographic reviews that provide a significant contribution to engineering and technology areas in all disciplines (Electronic, Electrical, Computer Science, Mechanic, Chemical, Environmental, Materials, Sanitary, Civil, Telecommunications, Industrial Engineering, and Bioengineering).
Evaluation of Knowledge, Attitude and Practice of General Practitioners regarding Oral Cancer in Tehran
Authors: Zarei Fatemeh , Sargeran Katayoun , Razavian Zeinabsadat 
Published: September 2023

Background: General practitioners (GPs) are the primary examiners of patients suspected of oral cavity cancer. The present study aims to determine the knowledge, attitude, and practice of general practitioners regarding oral cancer in Tehran.
Methods: A 17-item questionnaire was applied to evaluate the knowledge, attitude, and practice of general practitioners in this cross-sectional, descriptive-analytical study, in 2019. The questionnaires were completed by 154 GPs participating in different medical congresses. Data were analyzed with a linear regression model using SPSS-25. P-value < 0.05 was considered statistically significant.
Results: Of 154 GPs, 44.8% were female with a mean age of 44.5 ± 13.3, mean clinical experience of 14.6 ± 11.6 years, and mean time of 16.9 ± 12.1 years elapsed from graduation. Age, sex, and marital status had no significant association with knowledge, attitude, and practice; however, the time elapsed from graduation had a significant indirect association with knowledge (p = 0.04), and mean clinical experience had a significant direct association with attitude towards oral cancer (p = 0.04).
Conclusion: Educational interventions are required to improve the GPs’ knowledge and practice to improve the early diagnosis and prevention of oral cancer.
Economic Advantages of Domestic Production of Biosimilar Medicines in Iran
Authors: Yousfi Nazila , Azadmehr Behniya , Hashemi Seyyed Ali , Khameneh Mohammadhossein Motevali , Peiravian Farzad 
Published: September 2023

Background: Biosimilars can be considered generic versions of branded biologic medicines. Substituting branded biologic medicines with biosimilars is important to reduce medication costs. In addition to reducing drug costs, the domestic production of biosimilars can provide many other economic benefits. Therefore, this study aimed to investigate the economic benefits of producing biosimilar medicines in Iran.
Methods: This study was done in 2021 through 2 qualitative and quantitative steps. In the first step, after literature review, the interview guide was designed and semi-structured interviews with experts continued until reaching the saturation point, after interviewing 9 experts from different fields (imports, production, and policy making). The data were coded and analyzed by thematic analysis using MaxQDA software and the economic benefits of producing the biosimilars in Iran were extracted. In the quantitative step, the price advantage of producing domestic biosimilars was analyzed as one of their most important economic advantages compared to its equivalent in reference countries. In addition, the same comparison was done for the main imported branded medicines.
Results: From the experts’ viewpoints, the most important economic effect of the domestic production of biosimilars was the reduction of medication costs through access to lower-priced medicines. The employment of professionals, development of new technologies, expansion of the pharmaceutical market, the reduction of foreign currency outflows, increased affordability and access to drugs, and ultimately the improvement of the health level of the society were the other economic aspects of these medicines. In the quantitative step, after comparing the prices of 23 domestic biosimilars with the prices of the equivalent medicines in reference countries, the prices of 21 medicines were lower than the average prices of equivalent biosimilars and the prices of 18 medicines were even lower than the minimum price of the equivalent biosimilars in the reference countries. In addition, the production of these drugs in the country is indirectly effective in reducing the price of the main branded drugs in the country, so that in the case of imported branded biologic medicines, out of 28 medicines, the prices of 26 medicines were lower than the average prices in the reference countries and the prices of 23 medicines were even lower than the minimum of prices in the reference countries.
Conclusion: Based on the results of the study, it was concluded that the domestic production of biosimilar medicines in Iran, in addition to increasing access to biological drugs and promoting public health, provides many economic benefits, including saving drug costs.
Paraoksonaz 1 gen polimorfizmleri (Q192r ve L55m) ve koroner yavaş akımla ilişkisi
Authors: AKGÜN Arzu , YAVUZKIR M. , AKBULUT Mehmet 
Published: September 2023

Amaç: Koroner yavaş akım (KYA), opak maddenin yavaş ilerlemesi ile karakterize anjiyografik bir antitedir ve aynı zamanda ve aterosklerozun erken bir göstergesi olduğu düşünülmektedir. İnsan paraoksonazı 1 (PON1), yüksek yoğunluklu lipoproteini (HDL) ve düşük yoğunluklu lipoproteini (LDL) oksidatif modifikasyonlardan korur. Paraoksonaz 1'in işleyişini etkileyen iki amino asit polimorfizmi (192Q/R ve 55L/M) vardır. PON1 iki genetik polimorfizmi ve koroner yavaş akım ile ilişkisini belirlemeyi amaçlıyoruz. Bildiğimiz kadarıyla çalışmamız PON1 gen polimorfizmleri (L55M ve Q192R) ile KYA ilişkisini değerlendiren ilk çalışmadır.
Gereç ve Yöntemler: Çalışmaya toplam 100 hasta dahil edildi ve normal koroner akım (NKA) ve KYA olmak üzere 2 gruba ayrıldı. rs854560 ve rs662 polimorfizmlerinin genomik dizileri polimeraz zincir reaksiyonu kullanılarak belirlendi. Araştırma protokolü Fırat Üniversitesi Kurumsal İnceleme Kurulu tarafından onaylanmıştır (Onay No:16).
Bulgular: Koroner yavaş akım grubunun yaş ortalaması 45,4±17 ve NKA grubunun 50,5±11 idi. Q ve R alellerini taşıma sıklığı açısından istatistiksel olarak fark vardı. Dual genotipler için, QQLM genotipi KYA grubunda daha yaygınken, QRLM genotipi NKA'de daha yaygındı. QQLM, RRLL, RRLM ve QRLM genotiplerine sahip hastalar ile sağlıklı bireyler arasında anlamlı fark bulundu.
Sonuçlar: Q aleli ile QQLM genotipi ve KYA arasında anlamlı bir ilişki bulduk ve bunların KYA için risk faktörleri olabileceğini düşündük. Ayrıca R aleli ile QRLM, RRLL ve RRLM genotiplerinin NKA grubunda daha yüksek olması ve istatistiksel olarak anlamlı bir ilişki bulunması bunların KYA için koruyucu faktörler olabileceğini düşündürdü.
Evaluation of Platelet Storage Lesion (PSL) Markers in SSP+ Platelet Additive Solution Added Canine Platelet Concentrates (CPC)
Authors: Joshi Paunas Kamlesh , Baranidharan G.R. , Kavitha S. , Gowri A. Mangala 
Published: September 2023

Background: To evaluate the Platelet Storage Lesion (PSL) markers and extended storage time for SSP+ added Canine Platelet Concentrates (CPC) beyond five days at 22°C.Fresh Canine CPCundergo certain metabolic and morphologic changes during storage. Estimation of PSL markers helps us better understand quality of the canine PC and to estimate the efficacy of SSP+ in increasing the life span of stored CPC. Methods: CPC was prepared from 350 ml of whole blood, collected from 6 apparently healthy donor dogs by buffy coat methodin a quadruple bag closed system. CPC was divided into four aliquots of 15 ml each with one control and three test groups with SSP+ additive solution in different concentrations (65%, 75%, 85%). The In vitro PSL markers including swirling, pH, glucose, lactate, bicarbonate, pO2, pCO2, platelet concentration, MPV and PDWwere evaluated on day 1, 5, 9 and 13 of storage. Result: The results were analysed by Two-way ANOVA wherein swirling, pH, glucose, lactate, bicarbonate, pO2, pCO2, platelet concentration, MPV showed significant difference (p less than 0.01) between the groups. Interaction between the additive concentrations and the days of storage revealed a pH on day 9 for 65% SSP+ to be similar to day 5 for Plasma stored CPC while swirling, lactate and bicarbonate were also better maintained for 65% SSP+ PAS added CPC till day 9.Addition of 65% SSP+ PAS to CPC evidenced increased shelf life up to 9 days at 22°C under agitation without significant deterioration in product quality.
How soil and climate variability within a vineyard can affect the heterogeneity of grapevine vigour and production
Authors: Pereyra Gustavo , Pellegrino Anne , Ferrer Milka , Gaudin Remi 
Published: September 2023

This study aimed to determine how within-plot soil heterogeneity combined with yearly climate variability can promote the heterogeneity of vine growth at plot level, and which soil-climate parameters influence final yield and berry composition the most. An 8-year experiment was conducted on grapevine in two zones of a vineyard (1 ha) differentiated according to grapevine vigour as determined by NDVI: high vigour (HV) and low vigour (LV). The heterogeneity of the soil properties (depth, texture and composition), plant growth (shoots and roots) and plant production (yield components and berry composition) were determined at plot level. Compared to the LV zone, the HV zone was associated with deeper soils, higher soil water and nitrogen availability, CEC and montmorillonite/illite ratio. More extended root systems, higher vegetative growth and higher yield were observed in the HV zone compared to the LV zone. Drier and warmer vintages increased the difference in heterogeneity of vine growth and yield between the two zones. Berry composition (primary and secondary metabolites) also differed between HV and LV zones but seemed unconnected to vigour and mainly depended on soil-climate-plant interactions over the years. The heterogeneity of plant vigour within the vineyard mainly resulted from differences in root exploration, soil profile and composition (notably montmorillonite/illite ratio). The present study identified soil and crop factors that, depending on weather conditions, can be drivers for reducing the heterogeneity of plant development and improving productivity at vineyard level.
The Impact Of Sustainability Reporting On Financial Performance: Evidence From Turkish FBT And TCL Sectors
Authors: Lehenchuk Serhii , Zhyhlei Iryna , Ivashko Olena , Gliszczyński Grzegorz 
Published: September 2023

This study investigated the impact of sustainability reporting on financial performance, with a focus on companies in the Turkish food, beverage and tobacco and textile, wearing apparel and leather sectors. The sustainability reports of 48 companies listed on the Istanbul Stock Exchange for 2022 were studied, and the quality of sustainability practices was determined by using a general index (Sustainability Reporting Disclosure Quality Index (SRDQI)) and three partial indices (Environmental Disclosure Quality Index, Social Disclosure Quality Index, and Corporate Governance Disclosure Quality Index (CGDQI)). To analyze the relationships between financial performance and sustainability practices two types of regression models were developed, based on which eight models were directly examined. The results indicate the complete absence of a statistically significant impact of SRDQI on all financial performance measures used. Among the partial indices, only CGDQI has a significant positive effect on the Assets Turnover Ratio. An analysis of the influence of control variables shows a multidirectional dependence of individual financial performance measures on the size of companies, their age, industry affiliation, as well as on the structure of capital used. Finally, this study provides directions for improving the institutional environment of sustainability reporting for Turkish companies.
Reliability Analysis of A MEMS Flow Sensor with Accelerated Degradation Test
Authors: Kang Qiaoqiao , Lin Yuzhe , Tao Jifang 
Published: September 2023

With the wide application of flow sensor, their reliability under extreme conditions has been concerned in recent years. The reliability of a Micro Electro Mechanical Systems flow sensor under temperature (Ts) is researched in this paper. Firstly, the Step-stress accelerated degradation test is designed. Because this flow sensor consists flow sensor chip and signal processing system, the accelerated degradation testing is implemented, respectively. While the results show that the biggest drift is 3.15% for flow sensor chips with 150℃ conditions, and 32.91% for this flowmeter. By analysis, it could be found that the attenuation of the signal processing system is significant to the degeneration of this flowmeter. The minimum drift of the signal processing system accounts for 82.01% of this flowmeter. Secondly, using the Coffin-Manson model, the relationship between cycle-index and Ts is established. And the lifetime with different Ts is estimated by the Arrhenius model. In addition, the Weibull distribution is applied to evaluate the lifetime distribution. Finally, the reliability function of the Weibull distribution is demonstrated, and the survival rate within one year is 87.69% with 85℃ conditions. Thus, by the application of accelerated degradation testing, the acquired results are innovative and original. This research illustrates the reliability research, which provides a relational database for the application of this flow sensor.
Iron Chelation in Patients with Myelodysplastic Syndromes and Myeloproliferative Neoplasms—Real-World Data from the German Non- Interventional Study EXCALIBUR
Authors: Schulz Felicitas , Hauch Ulrich , Ketzler-Henkel Sandra , Von der Heyde Eyck , Koenigsmann Michael , Lauseker Michael , Schulte Nora , Germing Ulrich 
Published: September 2023

Myelodysplastic syndromes and myeloproliferative neoplasms both represent hematologic diseases associated with bone marrow failure often resulting in anemia. For those patients, transfusion of red blood cell (RBC) units is essential, but results in iron overload (IOL) that may affect various organ functions. Therefore, iron chelation therapy plays a major role in anemic patients, not only because it reduces IOL, but also because it may improve hematopoietic function by increasing hemoglobin or diminishing requirement of RBC transfusions. To assess the utility, efficacy and safety of the different iron chelation medication approved in Germany as well as to examine the effect of chelation on hematopoietic insufficiency, a prospective, multicenter, non-interventional study named EXCALIBUR was designed. In total, 502 patients from 106 German hospitals and medical practices were enrolled. A large proportion of patients switched from deferasirox dispersible tablet to deferasirox film-coated tablet, mainly due to more convenient application which was reflected in the treatment satisfaction questionnaire for medication scores. Iron chelation was effective in lowering serum ferritin levels, with the observed adverse drug reactions being in line with the known safety profile. Hematologic response occurred in a few patients, comparable to other studies that examined hematologic improvement in patients with MDS.
Partition Dimention of Amalgamation-Side in Cycle Graph
Authors: Nanda Ananda Dwi Nabila , Hasmawati Hasmawati , Nur Muh. 
Published: September 2023

The graph is a pair of sets , where is a finite set whose elements are called vertices, and is the set of pairs of members of . which is called the edge. Let be a simple graph where . The distance between points and is denoted by is the length of the shortest path between and . Given and there is a vertex on the connected graph , then the distance between and is denoted . If is -partition of , then the representation of with respect to is -ordered pairs, . If the -ordered pairs for are all different, then the partition is called a dimension partition. The minimal -number which is the -differentiating partition of is called the partition dimension of and is denoted by . In this study, the partition dimensions of the sided amalgamation result will be determined on an even-order cycle graph. In determining the dimensions of the partition, characterization of the partition dimensions is used in the path graph, the lemma about the distinguishing set and the equivalence point, especially in the even-order cycle graph. The results of this study are pd(Amal(Cn,e,k)) = 3 for n≥4 , pd(Amal(C4,e,k))=4 for k=4 , pd(Amal(C4,e,k))=3+m for k=2m+3 and k=2m+4 where m=1,2,3,...
Modification and Characterization of Some New Levofloxacin Heterocyclic Derivatives as COX-2 Enzyme Inhibitors and Evaluate Their Efficacy Pharmacokinetics by Molecular Docking and the Swiss ADME Studies
Authors: Rabeaa Mustafa Moaied , Khalaf Muna Ismael 
Published: September 2023

من أجل التنبؤ بالنشاط المضاد للالتهابات ضد انزيمات (COX-2) وتوقع إمكاناتها المضادة للسرطان ، حضرت مشتقات جديدة 1،2،4-تريازول-5-ثايول ، أوكسادايازول وإيمايد. تم استخدام الخصائص الفيزيائية ، H1-NMR ، C13-NMR ، التحليل الطيفي FT-IR ، وطرق أخرى لتوصيف وتحديد المركبات المنتجة. استندت المركبات التي تم إنشاؤها حديثًا (1-10) جزئيًا إلى الأدوية المعروفة المضادة للالتهابات الليفوفلوكساسين. تم استخدام برنامج دراسة ADMET السويسري لإجراء تقنيات حسابية المختص في علم الادوية والعقاقير ويصف كيفية تعامل جسم الكائن الحي مع المركبات الصيدلانية بعد تناولها وكذلك التنبؤ بالحركة الدوائية للعقاقير الجديدة و لتقييم انتقائية المركبات التي تم تحضيرها اتجاه إنزيم COX-2 أظهرت النتائج أن جميع المركبات تتوافق مع قاعدة Lipinski الصيدلانية للمركبات المحضرة. درست قيم طاقة الارتباط PLP أعلى من المركب المرجعي من خلال دراسات الالتحام الجزيئي لتفاعلات الترابط مع بروتين COX-2 للارتباط بالأحماض الأمينية في الدواء الاساسي (Levofloxacin). وكذلك تم التنبؤ عن تحسس الشحمية واستقطاب الجزيئات الصغيرة من خلال نموذج البيضة المسلوقة التي تقترح طريقة تغلغل الدماغ والامعاء بالإضافة الى النظام الغذائي لنفس الخصائص الكيميائية والفيزيائية وترجمتها المباشرة في تصميم جزيئة الدواء.
Efficient Approach for the Localization of Copy-Move Forgeries Using PointRend with RegNetX
Authors: Farhan Mahmoud H. , Shaker Khalid , Al-Janabi Sufyan 
Published: September 2023

الصور الرقمية هي أحد المصادر ذات الهيمنة العالية للمعلومات والاتصالات في العصر الحديث. ولكن يمكن بكل بساطة تغيير الصورة والتعديل عليها بسبب وفرة الادوات لتحرير الصور. يمكن أن تنتقل هذه الصور التي تم التعديل عليها عبر منصات وسائل التواصل الاجتماعي للتأثير على مجموعة من الأشخاص في المجتمع وقد تكون لها آثار إيجابية او سلبية. لتلك الأسباب أصبح تطوير تقنيات اكتشاف التزوير في الصور وتحديد موقعه مسألة ذات أهمية كبيرة. تزويرالـ (CMF) Copy move هو أحد أكثر عمليات التزوير شيوعًا. في هذا النوع CMF صورة التزوير الجديدة يتم إنشاءها عن طريق نسخ جزء معين من الصورة ووضعه في مكان اخر على نفس تلك الصورة. تقترح هذه الورقة البحثية تقنية PointRend كأسلوب لتحديد موقع الـ CMF. يقدم هذا العمل أيضًا باستخدام تقنية PointRend مع نموذج أساسي أقل حجما ((RegNetX backbone كنموذج مقترح (PointRend-RegNetX) لاكتشاف مثل هذه التزويرات. من التحليل المقارن للنموذج المقترح مع النموذج القياسي الذي يستخدم النموذج الأساسي ResNet-50 على مجموعتي بيانات قياسيتين، تبين أن النموذج المقترح (PointRend-RegNetX) قد تفوق على النموذج القياسي في كلا مجموعتي البيانات MICC F-220 وMICC F-2000 للصور التي تحتوي على تزوير الـ CMF. في حالات تحديد موقع المناطق المزورة، حقق النموذج المحسن(PointRend-RegNetX) متوسط معدل دقة (mAP) بنسبة 88.5 % على مجموعة البيانات MICC F-220 و86.4 % على مجموعة البيانات MICC F-2000.