bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sex‐based differences in safety and efficacy of catheter ablation for atrial fibrillation
Authors: Yadav Ritu , Milstein Jenna , Blum Jacob , Lazieh Stefany , Yang Victor , Zhao Xiyu , Muquit Siam , Malwankar Jui , Marine Joseph E. , Berger Ronald , Calkins Hugh , Spragg David 
Published: June 2023

AbstractBackgroundStudies have identified significant sex‐based differences and disparities in the clinical presentation and treatment of atrial fibrillation (AF). Studies have shown women are less likely to be referred for catheter ablation, are older at the time of ablation, and are more likely to have recurrence after ablation. However, in most studies investigating AF ablation outcomes, the female cohorts were relatively small. The impact of sex on the outcome and safety of ablation procedures is still unclear.ObjectiveTo investigate sex‐based differences in outcomes and complications after AF catheter ablation, with a significant female cohortMethodIn this retrospective study, patients undergoing AF ablation from January 1, 2014, to March 31, 2021, were included. We investigated clinical characteristics, duration and progression of AF, number of EP appointments from diagnosis to ablation, procedural data, and procedure complications.ResultsTotal of 1346 patients underwent first catheter ablation for AF during this period, including 896 (66.5%) male and 450 (33.4%) female patients. Female patients were older at the time of ablation (66.2 vs. 62.4 years; p < .001). Women had higher CHA2DS2‐VASc (congestive heart failure, hypertension, age, diabetes, stroke, vascular disease, sex category) scores (3 vs. 2; p < .001) than men, expectedly, as the female sex warrants an additional point. 25.3% female patients had PersAF at the time of diagnosis versus 35.3% male patients (p < .001). At the time of ablation, 31.8% female patients had PersAF as compared to 43.1% male patients (p < .001), indicating progression of PAF to PersAF in both sexes. Women tried more AADs than men before ablation (1.13 vs. 0.98; p = .002). Male and female patients had no statistically significant difference in (a) arrhythmia recurrence at 1‐year post ablation (27.7% vs. 30%; p = .38) or (b) procedural complication rate (1.8% vs. 3.1%; p = .56).ConclusionFemale patients were older and had higher CHA2DS2‐VASc scores compared to males at the time of AF ablation. Women tried more AADs than men before ablation. One‐year arrhythmia recurrence rates and procedural complications were similar in both sexes. No sex‐based differences were observed in safety and efficacy of ablation.
Elucidating the trophic role of Tapinoma ibericum (Hymenoptera: Formicidae) as a potential predator of olive pests
Authors: Álvarez Hugo Alejandro , García‐García Antonio , Sandoval Pedro , Martín‐Blázquez Ruben , Seifert Bernhard , Tinaut Alberto , Ruano Francisca 
Published: June 2023

AbstractAnts play a key role in improving the structure and function of local communities. They interact with plants, herbivores, predators and parasitoids and are able to change their trophic role in space and time. These features, however, make it difficult to establish the net trophic role of ants in agroecosystems. Here we aim to determine the isotopic enrichment and tissue incorporation rates in ants of the Tapinoma nigerrimum complex, which are found abundantly in olive orchards (i.e. T. ibericum), to determine their trophic role through stable isotopes analysis. We compared the isotopic signature of ants feeding on (1) natural diets, (2) experimental diets and (3) contrasting diets of ants inhabiting natural habitats and olive orchards with different management systems. Then, we contrasted our isotopic results on natural diets with the prey of ant foragers in olive orchards. Our results showed that (1) ants from olive orchards had an isotopic signature different from that of a hyper‐predator; (2) the isotopic signature did not vary significantly amongst different management practices and (3) the diet of ants in nature varies greatly on preys according to resource availability, which may be reflected in isotopic signatures. Therefore, T. ibericum is a species that can potentially contribute to control olive pests without posing a risk to other natural enemies because commonly it is not a hyper‐predator. The information presented here could be used by farmers and technicians to enhance local biological control planning and/or strategies in olive orchards.
Combined effects of high hydrostatic pressure and chemical pre‐treatment on physico‐chemical properties of beef, using FTIR and diffuse reflectance spectroscopy
Authors: Giménez Belén , Rodríguez Hernán B. , Graiver Natalia , Zaritzky Noemí 
Published: June 2023

AbstractHigh pressure processing (HPP) was combined with a previous short chemical treatment to stabilize the color of beef tissue. Beef samples were treated with a solution containing ascorbic acid, sodium chloride, and a very low concentration of sodium nitrite. The effects of pressure levels (0.1–600 MPa) and preservative solution on: (i) color properties based on diffuse reflectance spectroscopy (DRS), which determines the relative concentrations of muscle pigments, (ii) protein denaturation and changes in the secondary structures by DSC and FTIR‐ATR, were determined.At high pressures, the disappearance of DSC peaks due to protein denaturation, a decrease in the proportion of α‐helix and an increase in the percentage of disordered structures, were evidenced. DRS spectra and Kublelka‐Munk theory equations demonstrated that nitrosilmyoglobin was a more stable chromophore, decreasing discoloration of the tissue. These techniques contribute to the knowledge of the physico‐chemical properties of the tissue submitted to combined preservation processes.Practical ApplicationsThere is an increasing demand from consumers for high‐quality beef products, with significant emphasis placed on color and safety attributes. Extending the shelf life by applying high hydrostatic pressure treatment (HHP) improves food safety and will produce a positive impact on both the industry and consumers. HHP is a non‐thermal preservation technology with generally minimal effects on sensory qualities and nutritional content; however, the direct application of this technology on beef leads to the production of a product with an unacceptable pale coloration. Therefore, it must be remarked that a pre‐treatment stage by immersing the pieces in a preservative solution is essential to improve the color of beef products treated by HHP. In this regard, from a technological point of view, it is very important to know the combined effects of both stages (short chemical treatment and high‐pressure) on the quality of beef products.
Singlehood during later life: Theoretical considerations for health and social relationships
Authors: Ermer Ashley E. , Keenoy Jaclyn Elisa 
Published: June 2023

AbstractOlder adults are a growing segment of the population. The number of single older adults is increasing, making older adulthood a salient developmental period to examine singlehood. In this article, we focus on older adults' singlehood experiences based on marital status and delve into theoretical perspectives and methodological approaches. Specifically, we focus on theories related to the life course and social constructionist perspectives. We include the cumulative advantage/disadvantage model, convalescence model, marital biographies, and social convoy model under life course perspectives and the gender as relational approach, ambiguous loss, and marriage as a greedy institution under social constructionist perspectives. To conclude, we examine how to integrate these theories and methodological considerations to better understand singlehood during later life. The integration of theory and methodologies can help guide research, which, in turn, allows for a more complete understanding of singlehood, which can bolster the quality of life for single older adults.
The risk of recurrent pancreatitis after first episode of acute pancreatitis in relation to etiology and severity of disease: A systematic review, meta‐analysis and meta‐regression analysis
Authors: Hajibandeh Shahab , Jurdon Rebecca , Heaton Emily , Hajibandeh Shahin , O'Reilly David 
Published: June 2023

AbstractBackground and AimThe study aims to determine and quantify the stratified risk of recurrent pancreatitis (RP) after the first episode of acute pancreatitis in relation to etiology and severity of disease.MethodsA systematic review and meta‐analysis in compliance with PRISMA statement standards was conducted. A search of electronic information sources was conducted to identify all studies investigating the risk of RP after the first episode of acute pancreatitis. Proportion meta‐analysis models using random effects were constructed to calculate the weighted summary risks of RP. Meta‐regression was performed to evaluate the effect of different variables on the pooled outcomes.ResultsAnalysis of 57,815 patients from 42 studies showed that the risk of RP after first episode was 19.8% (95% confidence interval [CI] 17.5–22.1%). The risk of RP was 11.9% (10.2–13.5%) after gallstone pancreatitis, 28.7% (23.5–33.9%) after alcohol‐induced pancreatitis, 30.3% (15.5–45.0%) after hyperlipidemia‐induced pancreatitis, 38.1% (28.9–47.3%) after autoimmune pancreatitis, 15.1% (11.6–18.6%) after idiopathic pancreatitis, 22.0% (16.9–27.1%) after mild pancreatitis, 23.9% (12.9–34.8%) after moderate pancreatitis, 21.6% (14.6–28.7%) after severe pancreatitis, and 6.6% (4.1–9.2%) after cholecystectomy following gallstone pancreatitis. Meta‐regression confirmed that the results were not affected by the year of study (P = 0.541), sample size (P = 0.064), length of follow‐up (P = 0.348), and age of patients (P = 0.138) in the included studies.ConclusionsThe risk of RP after the first episode of acute pancreatitis seems to be affected by the etiology of pancreatitis but not the severity of disease. The risks seem to be higher in patients with autoimmune pancreatitis, hyperlipidemia‐induced pancreatitis, and alcohol‐induced pancreatitis and lower in patients with gallstone pancreatitis and idiopathic pancreatitis.
The significance of nonsurgical therapies for cervical infection of high‐risk human papilloma virus: A systematic review and meta‐analysis
Authors: Zhuang Yuan , Yang Hua 
Published: June 2023

AbstractObjectiveTo assess whether nonsurgical therapies were related with clearance of cervical infection of high‐risk human papilloma virus (hr‐HPV) or regression of mild abnormal cytology related with hr‐HPV.MethodsUntil March 2023, we identified a total of 10 424 women with cervical infection of hr‐HPV and 1966 women with mild abnormal cytology related with hr‐HPV from 44 studies that met the inclusion criteria.ResultsAfter systematically retrieving literature, we identified 2317 citations and 44 randomized controlled studies (RCT) were enrolled. Cumulative results suggested women with cervical infection of hr‐HPV might benefit from nonsurgical therapies. Both the clearance of hr‐HPV (OR: 3.83, I2 = 99%, p < 0.00001) and regression of mild abnormal cytology related with hr‐HPV (OR: 3.12, I2 = 63%, p < 0.00001) were significantly higher than control group. Subgroup analysis stratified by systematic therapy, topical therapy, traditional Chinese medicines (TCMs), and presistent hr‐HPV got consistent results. There was substantial heterogeneity between trials (I2 = 87% for clearance of hr‐HPV and 63% for regression of cytology), sensitivity analysis was performed by excluding single study one by one, and found the cumulative results were stable and dependable. Both the funnel plots for clearance of hr‐HPV and regression of abnormal cytology were asymmetrical, significant publication bias might exist.ConclusionNonsurgical therapies might benefit women who had a cervical infection of hr‐HPV with/without mild abnormal cytology related with hr‐HPV. Both the clearance of hr‐HPV and regression of abnormal cytology were significantly higher than control group. More studies with less heterogeneity were needed urgently to draw concrete conclusion.
Hepatitis D virus infection, innate immune response and antiviral treatments in stem cell‐derived hepatocytes
Authors: Lange Frauke , Garn Jonathan , Anagho Holda A. , Vondran Florian W. R. , von Hahn Thomas , Pietschmann Thomas , Carpentier Arnaud 
Published: June 2023

AbstractBackgroundHuman pluripotent stem cell (hPSC)‐derived hepatocyte‐like cells (HLCs) are a valuable model to investigate host‐pathogen interactions of hepatitis viruses in a mature and authentic environment. Here, we investigate the susceptibility of HLCs to the hepatitis delta virus (HDV).MethodsWe differentiated hPSC into HLCs, and inoculated them with infectious HDV produced in Huh7NTCP. HDV infection and cellular response was monitored by RTqPCR and immunostaining.ResultsCells undergoing hepatic differentiation become susceptible to HDV after acquiring expression of the viral receptor Na+‐taurocholate co‐transporting polypeptide (NTCP) during hepatic specification. Inoculation of HLCs with HDV leads to detection of intracellular HDV RNA and accumulation of the HDV antigen in the cells. Upon infection, the HLCs mounted an innate immune response based on induction of the interferons IFNB and L, and upregulation of interferon‐stimulated genes. The intensity of this immune response positively correlated with the level of viral replication and was dependant on both the JAK/STAT and NFκB pathway activation. Importantly, this innate immune response did not inhibit HDV replication. However, pre‐treatment of the HLCs with IFNα2b reduced viral infection, suggesting that ISGs may limit early stages of infection. Myrcludex efficiently abrogated infection and blocked innate immune activation. Lonafarnib treatment of HDV mono infected HLCs on the other hand led to exacerbated viral replication and innate immune response.ConclusionThe HDV in vitro mono‐infection model represents a new tool to study HDV replication, its host‐pathogen interactions and evaluate new antiviral drugs in cells displaying mature hepatic functions.
Music Education and Neurophysiological Regulation in Early Childhood: Should Teachers Guide or Get Out of the Way?
Authors: Brown Eleanor D. , Holochwost Steven J. , Palmer Wolf Dennie , Allen Alyssa A. , Garnett Mallory L. , Velazquez‐Martin Blanca , Varnell Suzanne , Malatesta Jessa L. 
Published: June 2023

ABSTRACTAccess to high‐quality early music education programs may mitigate the effects of poverty on the hypothalamic–pituitary–adrenal (HPA) axis, but fundamental questions remain about the role of early educators in conveying these benefits. In the current study, we measured the basal or resting cortisol levels of 76 children (Mage = 4.17 years; 42% female) over the course of the school day while they attended a Head Start preschool that included early music education classes. The results of a series of hierarchical linear models (HLMs) indicated that child‐directed music and movement activities during these classes were associated with lower levels of cortisol (relative to teacher‐directed activities; B = −0.019, p = .013), as were higher quality teacher–child interactions (B = −0.018, p = .013); both associations were moderated by child age. We discuss the implications of these results for future educational neuroscience research that seeks to inform early education programs for young children placed at risk by poverty.
A vacuolar transporter plays important roles in zinc and cadmium accumulation in rice grain
Authors: Ning Min , Liu Shi Jia , Deng Fenglin , Huang Liyu , Li Hu , Che Jing , Yamaji Naoki , Hu Fengyi , Lei Gui Jie 
Published: June 2023

Summary

Rice grain is a poor dietary source of zinc (Zn) but the primary source of cadmium (Cd) for humans; however, the molecular mechanisms for their accumulation in rice grain remain incompletely understood.

This study functionally characterized a tonoplast‐localized transporter, OsMTP1. OsMTP1 was preferentially expressed in the roots, aleurone layer, and embryo of seeds. OsMTP1 knockout decreased Zn concentration in the root cell sap, roots, aleurone layer and embryo, and subsequently increased Zn concentration in shoots and polished rice (endosperm) without yield penalty. OsMTP1 haplotype analysis revealed elite alleles associated with increased Zn level in polished rice, mostly because of the decreased OsMTP1 transcripts.

OsMTP1 expression in yeast enhanced Zn tolerance but did not affect that of Cd. While OsMTP1 knockout resulted in decreased uptake, translocation and accumulation of Cd in plant and rice grain, which could be attributed to the indirect effects of altered Zn accumulation.

Our results suggest that rice OsMTP1 primarily functions as a tonoplast‐localized transporter for sequestrating Zn into vacuole. OsMTP1 knockout elevated Zn concentration but prevented Cd deposition in polished rice without yield penalty. Thus, OsMTP1 is a candidate gene for enhancing Zn level and reducing Cd level in rice grains.
Characterization of wound microbes in epidermolysis bullosa: A focus on Pseudomonas aeruginosa
Authors: Scollan Margaret E. , Levin Laura E. , Lucky Anne W. , Hook Kristen P. , Peoples Kathleen , Bruckner Anna L. , Feinstein James A. , Pope Elena , McCuaig Catherine C. , Powell Julie , Eichenfield Lawrence F. , Levy Moise L. , Diaz Lucia , Glick Sharon A. , Paller Amy S. , Browning John C. , Morel Kimberly D. 
Published: June 2023

AbstractThe most common bacteria isolated from wound cultures in patients recorded in the Epidermolysis Bullosa Clinical Characterization and Outcomes Database (EBCCOD) are Staphylococcus aureus and Pseudomonas aeruginosa. Given the prevalence of P. aeruginosa in this patient population and prior research implicating P. aeruginosa's potential role in carcinogenesis, we sought to further analyze patients with recorded wound cultures positive for Pseudomonas aeruginosa in the EBCCOD. We provide a descriptive analysis of this subset of patients and highlight potential avenues for future longitudinal studies that may have significant implications in our wound care management for patients with epidermolysis bullosa.
You'll never walk alone: Loneliness, religion, and politico‐economic transformation
Authors: Tubadji Annie 
Published: June 2023

AbstractThe rise of subversive religious beliefs has been recently documented as related to the politico‐economic radicalization of places that feel left behind. When is the traditional local religious institution so socio‐economically inefficient in providing hope for “not walking alone” to become substituted by subversive religious beliefs on the market for hope? This article suggests a detailed methodology, linking micro and macro levels, that starts from the quantification of the individual gain from religion as a source for well‐being by providing the feeling of “not walking alone.” This micro gain is next used: (i) to evaluate a religious institution in terms of the social welfare that it generates, and (ii) to monitor this religious institution for losing its market to subversive religious beliefs, related to radical politico‐economic transformations. To illustrate this methodology, I analyze the socio‐economic efficiency of the Church of England as a predictive tool for the Brexit vote.Related ArticlesGainous, Jason, and Bill Radunovich. 2008. “Religion and Core Values: A Reformulation of the Funnel of Causality.” Politics & Policy 33(1): 154–80. https://doi.org/10.1111/j.1747‐1346.2005.tb00213.x.Giugni, Marco, and Maria T. Grasso. 2016. “How Civil Society Actors Responded to the Economic Crisis: The Interaction of Material Deprivation and Perceptions of Political Opportunity Structures.” Politics & Policy 44(3): 447–72. http://onlinelibrary.wiley.com/doi/10.1111/polp.12157/abstract.Temple, Luke, Maria T. Grasso, Barbara Buraczynska, Sotirios Karampampas, and Patrick English. 2016. “Neoliberal Narrative in Times of Economic Crisis: A Political Claims Analysis of the U.K. Press, 2007–14.” Politics & Policy 44(3): 553–76. https://doi.org/10.1111/polp.12161.
Misrecognition and Well‐being in Culturally White Northern New England☆
Authors: Walton Emily 
Published: June 2023

AbstractRural America is undergoing a demographic transition, as the white population decline is matched by a growing movement of racialized minorities into small towns. In the current study, I examine processes of belonging among middle‐class racialized minorities living in predominantly white and rural Northern New England. Through an analysis of in‐depth interviews with n = 58 individuals of color, I show how “misrecognition,” or the processes through which community members fail to affirm the humanity of others, can lead to diminished well‐being. I elaborate a novel conceptual model linking a stigmatizing cultural context (chilly social climate; ignorance and racism) with misrecognition (social distancing; having to prove oneself) and well‐being (unease; weariness). The study's main contribution is the generation of theory regarding symbolic boundary processes that undergird racialized minority residents' negotiation of the right to belong in a rapidly changing rural America.
Endoplasmic reticulum stress in T cell‐mediated diseases
Authors: Chen Shaodan , Wang Qiulei , Wang Hui , Xia Sheng 
Published: June 2023

AbstractT cells synthesize a large number of proteins during their development, activation, and differentiation. The build‐up of misfolded and unfolded proteins in the endoplasmic reticulum, however, causes endoplasmic reticulum (ER) stress. Thus, T cells can maintain ER homeostasis via endoplasmic reticulum‐associated degradation, unfolded protein response, and autophagy. In T cell‐mediated diseases, such as rheumatoid arthritis, systemic lupus erythematosus, Sjogren's syndrome, type 1 diabetes and vitiligo, ER stress caused by changes in the internal microenvironment can cause disease progression by affecting T cell homeostasis. This review discusses ER stress in T cell formation, activation, differentiation, and T cell‐mediated illnesses, and may offer new perspectives on the involvement of T cells in autoimmune disorders and cancer.
Evaluation of adapted dermocosmetic regimens for perimenopausal and menopausal women using an artificial intelligence‐based algorithm and quality of life questionnaires: An open observational study
Authors: Flament Frederic , Jiang Ruowei , Delaunay Caroline , Kerob Delphine , Leclerc‐Mercier Stéphanie , Kosmadaki Marita , Roó Elia , Haag Thierry , Passeron Thierry , Zouboulis Christos C. 
Published: June 2023

AbstractBackgroundThe decline in estrogen levels from several years before (perimenopause) and during menopause has various negative effects, including skin specific issues, which often receive less attention than other menopausal symptoms despite having a significant negative effect on quality of life (QoL). The objective of this study was to evaluate the effectiveness of anti‐aging dermocosmetic products designed for women during the perimenopause and menopause.Materials and methodsAn open study of 101 perimenopausal women (no menstruation for 4–12 months or irregular menstruation for <5 years) and 101 menopausal women (no menstruation for >12 months), not taking hormone replacement therapy, was conducted. Adapted dermocosmetic regimens, specific to each group (day cream, night cream and serum), were applied for 56 days. Assessments included automatic artificial intelligence diagnostics of eight clinical facial signs, hydration and transepidermal water loss (TEWL), and a menopause skin QoL questionnaire.ResultsMean age was 50 ± 3.9 years (range 41–57) and 59 ± 3.8 years (range 50–66) for the perimenopause and menopause groups, respectively. Significant improvements in wrinkles and vascular signs, increases in hydration, decreases in TEWL, and a positive impact on QoL were observed after 56 days of application of the respective dermocosmetic regimens for both the perimenopause and menopause groups.ConclusionThe anti‐aging skin care products designed specifically for perimenopausal and menopausal women increased skin hydration and improved wrinkles with a positive impact on QoL.