bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk Factors Typhoid Fever Incidence at Lau Health Center, Lau District, Maros Regency in 2021
Authors: Rosdiana Rosdiana , Idrus Hasta Handayani , Syahruddin Febie Irsandy , Yanti Andi Kartini Eka , Arifin Arina Fathiyyah 
Published: June 2023

Background: Typhoid fever is disease caused by the bacterium Salmonella typhi genus Salmonella. Until now, disease fever typhoid still is problem health in tropical countries including Indonesia. Knowing risk factor incident fever Typhoid at the Lau Public Health Center, Lau district, Maros regency in 2021
Method: Research type analytic observational with case control design. The data analysis technique uses the chi-square statistical test.
Results: Typhoid Fever mostly found in the age 11-19 years as many as 21 people ( P-value 0.049), gender obtained that the most in men as many as 22 people ( P-value 0.014), level primary school education is obtained as many as 14 people ( P-value 0.07), habit wash hand before eat less good obtained as many as 17 people ( P-value 0.044), habit wash hand after less CHAPTER good obtained as many as 19 people ( P-value 0.013), habit eat / snack outside house obtained as many as 23 people ( P-value 0.026), habit wash ingredients food less raw good obtained as many as 18 people ( P-value 0.046) and sanitation less environment good obtained as many as 25 people P-value 0.041) .
Conclusion: Based on results study concluded that on the variable age , gender , education , habits wash hand before eat , habit wash hand after defecation, habit eat / snack outside home , custom wash ingredients food raw and sanitary environment own connection with factor risk incident fever typhoid in the health center lau districts lau districts maros year 2021.
Analisis Kualitas Layanan Lanside Terhadap Kepuasan Pengguna Jasa pada Bandar Udara Internasional Sultan Hasanuddin Makassar
Authors: Mansyur Titien Putri , Said Lambang Basri , Syafei Ilham 
Published: June 2023

Dinamika persaingan maskapai penerbangan menuntut kesiapan bandar udara untuk merespon persaingan dengan melakukan pelayanan yang dapat menampung baik pesawat cargo maupun penumpang yang keluar masuk di bandara Internasional Sultan Hasanuddin. Hal ini dapat dibuktikan adanya kencederungan penambahan jumlah maskapai penerbangan yang masuk dan keluar dari dan dari Bandar Udara Internasional Sultan Hasanuddin. Tujuan dari penelitian ini adalah menganalisis Kualitas Layanan pada daerah landside Bandara terhadap Kepuasan Pengguna jasa pada Bandar Udara Sultan Hasanuddin Makassar. Berdasar pada teori tingkat Kepuasan Pelayanan, mencakup 6 variabel bebas (X). Metode penelitian menggunakan pendekatan statistik dengan analisis deskriptif kualitatif melalui software Reeresi. Berdasarkan hasil penelitian diperoleh model regeresi yang diperoleh berdasar pada hasil analisis, yaitu: Y = 0,435+ 0,188X1 + 0,180X2 + 0,185X3+ 0,175X4 + 0,126X5+ 0,159X6 dan (R2 = 0,992 atau 99,2%.). Dalam persamaan tersebut terlihat bahwa faktor-faktor yang paling mempengaruhi adalah Karakter Pekerja (X1, X2, X3). Adapun nilai R2= 0,992 menandakan bahwa variabel-variabel tersebut memiliki pengaruh sebesar 99,2% terhadap tingkat kepuasan pelayanan Bandar Udara Sultan Hasanuddin Makassar.
Usage of the New Modifier-curing Agent in Plywood Technology: The Influence to Urea-formaldehyde Resin Curing and Formaldehyde Emission
Authors: Ivanov Daniil , Ekaterincheva Mariya , Kalashnikov Aleksey , Baca Ksenya , Mazur Anton 
Published: June 2023

One of the urgent scientific and technical objectives in the technologies of plywood and wood boards is the search for ways to reduce of hot pressing time without increasing the formaldehyde emission from finished products. To solve this problem was developed the new modifier-curing agent MC-4SF, is mainly a product of interaction of citric acid with urea and ammonia. Compared to traditional ammonium salts, the modifier-curing agent combines the properties of both direct and latent catalysts. Determination of the composition of residual methylol groups in the aqueous extracts obtained by treating the resin cured at 100 °C showed that the modifier-curing agent provides relatively high hydrolytic stability of the UF-polymer during extraction. Spectra of solid-state 13C NMR showed that in resins cured with MC-4SF increased the compound of methylene bridges compared to resins cured with standard catalysts. It is possible that the amino groups of urea (or its derivatives) included in the modifier-curing agent, react with the methylol groups of UF oligomers, fitting urea into the structure of the resulting polymer. Thus explains the increased hydrolytic stability and reduced toxicity of the cured resin. Manufacturing tests of nine-layer plywood made with a modifier-curing agent showed that replacing ammonium sulfate with MC-4SF allows a significant reduction in pressing time at 110 °C without loss of quality of the finished product. With the same pressing time, it was possible to increase the line shear strength by 14% and to reduce formaldehyde emission by 45%.
KEMAMPUAN PENYERAPAN TIMBAL (PB) PADA BEBERAPA KULTIVAR TANAMAN PURING (CODIAEUM VARIEGATUM)
Authors: Susi Sulistiana  , Ludivica Endang Setijorini  
Published: June 2023

This study aims to determine the content of heavy metal lead (Pb) accumulated in shoots, leaves, and stems croton plant, as well as the effectiveness of 18 cultivars of the croton plant in accumulating Pb in the air of Housing Batan Indah, Serpong, South Tangerang. Sampling is purposive sampling point at 2 locations/stations on the street/block F, G, H, I, J, K, L, M, and N (9 street/block). Each block consists of the first point, namely the location of the dense traffic (approximately 50 m from the highway) and the second point, namely the quiet location of traffic (approximately 250 m from the highway). There are 18 samples, each of which consists of shoots, leaves, and stems of plants croton. Pb concentrate is analyzed by X-Ray Fluorescence X-MET 510 methods. The results showed that croton plant Pb uptake in dense traffic locations higher (shoots: 18.78 Âµg/g; leaf: 26.89 Âµg/g, and rods: 102.15 Âµg/g) compared with the quiet location of traffic (shoots: 13.93 Âµg/g; leaves: 21.07 Âµg/g, and rods: 68.43 Âµg/g). Number of croton cultivars found is 13 cultivars. The best of Pb absorber is stems (220.67 Âµg/g), from Pictum Spot cultivar that have small leaves. The best Pb absorber to shoots (26 Âµg/g) and leaves (44.33 Âµg/g) is from Malang apple cultivar. Both cultivars are located in dense traffic location
Penelitian ini bertujuan untuk mengetahui kandungan logam berat timbal (Pb) yang terakumulasi pada pucuk, daun, dan batang tanaman puring, dan kemampuan 18 kultivar tanaman jalan puring dalam mengakumulasi Pb dari udara di lingkungan Perumahan Batan Indah, Kecamatan Serpong, Tangerang Selatan. Pengambilan sampel bersifat purposive sampling pada 2 titik lokasi pada jalan F, G, H, I, J, K, L, M, dan N (9 jalan). Masing-masing terdiri atas titik pertama, yaitu lokasi yang padat lalu lintas (sekitar 50 m dari jalan raya) dan titik ke-dua, yaitu lokasi yang relatif sepi lalu lintas (sekitar 250 m dari jalan raya). Sehingga terdapat 18 sampel yang masing-masing terdiri atas pucuk, daun, dan batang tanaman puring. Penetapan kadar Pb dilakukan dengan menggunakan metode spektrometri pendar Sinar-X, dan dilanjutkan penentuan kandungan Pb dengan teknik kurva kalibrasi. Hasil penelitian menunjukkan penyerapan Pb tanaman puring pada lokasi padat lalu lintas lebih tinggi (pucuk: 18.78 Âµg/gr; daun: 26.89 Âµg/gr; dan batang: 102.15 Âµg/gr) dibandingkan dengan lokasi yang sepi lalu lintas (pucuk: 13.93 Âµg/gr; daun: 21.07 Âµg/gr; dan batang: 68.43 Âµg/gr). Jumlah kultivar puring yang ditemukan berdasarkan identifikasi adalah13 kultivar. Bagian tanaman penyerap Pb paling baik adalah batang (220.67Âµg/gr), yaitu dari kultivar Pictum Spot yang berada di lokasi yang padat lalu lintas. Penyerap Pb yang terbaik pada pucuk (26 Âµg/gr) dan daun (44.33Âµg/gr) adalah dari kultivar Apel Malang.
AI-enabled case detection model for infectious disease outbreaks in resource-limited settings
Authors: Sisimayi Chenjerai , Harley Charis , Nyabadza Farai , Visaya Maria Vivien 
Published: June 2023

IntroductionThe utility of non-contact technologies for screening infectious diseases such as COVID-19 can be enhanced by improving the underlying Artificial Intelligence (AI) models and integrating them into data visualization frameworks. AI models that are a fusion of different Machine Learning (ML) models where one has leveraged the different positive attributes of these models have the potential to perform better in detecting infectious diseases such as COVID-19. Furthermore, integrating other patient data such as clinical, socio-demographic, economic and environmental variables with the image data (e.g., chest X-rays) can enhance the detection capacity of these models.MethodsIn this study, we explore the use of chest X-ray data in training an optimized hybrid AI model based on a real-world dataset with limited sample size to screen patients with COVID-19. We develop a hybrid Convolutional Neural Network (CNN) and Random Forest (RF) model based on image features extracted through a CNN and EfficientNet B0 Transfer Learning Model and applied to an RF classifier. Our approach includes an intermediate step of using the RF's wrapper function, the Boruta Algorithm, to select important variable features and further reduce the number of features prior to using the RF model.Results and discussionThe new model obtained an accuracy and recall of 96% for both and outperformed the base CNN model and four other experimental models that combined transfer learning and alternative options for dimensionality reduction. The performance of the model fares closely to relatively similar models previously developed, which were trained on large datasets drawn from different country contexts. The performance of the model is very close to that of the “gold standard” PCR tests, which demonstrates the potential for use of this approach to efficiently scale-up surveillance and screening capacities in resource limited settings.
Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells Hold Lower Heterogeneity and Great Promise in Biological Research and Clinical Applications
Authors: Zhang Juan , Chen Mingzhuang , Liao Jinqi , Chang Chongfei , Liu Yuqing , Padhiar Arshad Ahmed , Zhou Yan , Zhou Guangqian 
Published: June 2023

Graphical AbstractInduced pluripotent stem cell-derived mesenchymal stem cells (iMSC) and primary MSC comparison: to show the advantages and applications of iMSC.
Unraveling the therapeutic mechanisms of dichloroacetic acid in lung cancer through integrated multi-omics approaches: metabolomics and transcriptomics
Authors: Feng Malong , Wang Ji , Zhou Jianying 
Published: June 2023

Objective: The aim of this study was to investigate the molecular mechanisms underlying the therapeutic effects of dichloroacetic acid (DCA) in lung cancer by integrating multi-omics approaches, as the current understanding of DCA’s role in cancer treatment remains insufficiently elucidated.Methods: We conducted a comprehensive analysis of publicly available RNA-seq and metabolomic datasets and established a subcutaneous xenograft model of lung cancer in BALB/c nude mice (n = 5 per group) treated with DCA (50 mg/kg, administered via intraperitoneal injection). Metabolomic profiling, gene expression analysis, and metabolite-gene interaction pathway analysis were employed to identify key pathways and molecular players involved in the response to DCA treatment. In vivo evaluation of DCA treatment on tumor growth and MIF gene expression was performed in the xenograft model.Results: Metabolomic profiling and gene expression analysis revealed significant alterations in metabolic pathways, including the Warburg effect and citric acid cycle, and identified the MIF gene as a potential therapeutic target in lung cancer. Our analysis indicated that DCA treatment led to a decrease in MIF gene expression and an increase in citric acid levels in the treatment group. Furthermore, we observed a potential interaction between citric acid and the MIF gene, suggesting a novel mechanism underlying the therapeutic effects of DCA in lung cancer.Conclusion: This study underscores the importance of integrated omics approaches in deciphering the complex molecular mechanisms of DCA treatment in lung cancer. The identification of key metabolic pathways and the novel finding of citric acid elevation, together with its interaction with the MIF gene, provide promising directions for the development of targeted therapeutic strategies and improving clinical outcomes for lung cancer patients.
A Rab33b missense mouse model for Smith-McCort dysplasia shows bone resorption defects and altered protein glycosylation
Authors: Dimori Milena , Pokrovskaya Irina D. , Liu Shijie , Sherrill John T. , Gomez-Acevedo Horacio , Fu Qiang , Storrie Brian , Lupashin Vladimir V. , Morello Roy 
Published: June 2023

Smith McCort (SMC) dysplasia is a rare, autosomal recessive, osteochondrodysplasia that can be caused by pathogenic variants in either RAB33B or DYM genes. These genes codes for proteins that are located at the Golgi apparatus and have a role in intracellular vesicle trafficking. We generated mice that carry a Rab33b disease-causing variant, c.136A&gt;C (p.Lys46Gln), which is identical to that of members from a consanguineous family diagnosed with SMC. In male mice at 4 months of age, the Rab33b variant caused a mild increase in trabecular bone thickness in the spine and femur and in femoral mid-shaft cortical thickness with a concomitant reduction of the femoral medullary area, suggesting a bone resorption defect. In spite of the increase in trabecular and cortical thickness, bone histomorphometry showed a 4-fold increase in osteoclast parameters in homozygous Rab33b mice suggesting a putative impairment in osteoclast function, while dynamic parameters of bone formation were similar in mutant versus control mice. Femur biomechanical tests showed an increased in yield load and a progressive elevation, from WT to heterozygote to homozygous mutants, of bone intrinsic properties. These findings suggest an overall impact on bone material properties which may be caused by disturbed protein glycosylation in cells contributing to skeletal formation, supported by the altered and variable pattern of lectin staining in murine and human tissue cultured cells and in liver and bone murine tissues. The mouse model only reproduced some of the features of the human disease and was sex-specific, manifesting in male but not female mice. Our data reveal a potential novel role of RAB33B in osteoclast function and protein glycosylation and their dysregulation in SMC and lay the foundation for future studies.
Advances in electronic skin research: a bibliometric analysis
Authors: Xu Shiyong , Yu Xiaona , Chen Jie , Jing Yuan 
Published: June 2023

Background: E-skin (electronic skin) is an active research area in human-computer interaction and artificial intelligence.Methods: A bibliometric analysis was performed to evaluate publications in the E-skin field between 2000 and 2021 based on the Web of Science (WoS) databases.Results: A total of 4,954 documents were identified. A detailed overview of E-skin research was presented from aspects of productive countries/regions, institutions, journals, citations, highly cited papers, keywords, and emerging topics. With the emergence of new functional materials, structural design, 3D printing, and nanofabrication techniques, E-skin research has achieved dramatic progress after 2013. Scholars and institutions in China, the United States and South Korea are leading the way in E-skin research. Pressure sensor, strain sensor, and flexible electronics are the most focused directions at present and Internet of things is the most emerging topic.Conclusion: E-skin research has achieved dramatic progress but there is still quite a challenging task in practical applications. Manufacturing process simplification, cost reduction, functional integration, energy supply, and biocompatibility are vital for the future development of E-skin.
Accuracy of Deep Neural Network in Triaging Common Skin Diseases of Primary Care Attention
Authors: Giavina-Bianchi Mara , Cordioli Eduardo , Santos André P. dos 
Published: June 2023

Graphical AbstractGraphical Abstract showing the research flow from the dataset base images, classification of the dermatoses according to categories, referral and level of priority; training and validation in different scenarios to the final test, using the algorithm with the best performance.
Monitoring of breast cancer progression via aptamer-based detection of circulating tumor cells in clinical blood samples
Authors: Kolovskaya Olga S. , Zyuzyukina Alena V. , Dassie Justin P. , Zamay Galina S. , Zamay Tatiana N. , Boyakova Nina V. , Khorzhevskii Vladimir A. , Kirichenko Daria A. , Lapin Ivan N. , Shchugoreva Irina A. , Artyushenko Polina V. , Tomilin Felix N. , Veprintsev Dmitry V. , Glazyrin Yury E. , Minic Zoran , Bozhenko Vladimir K. , Kudinova Elena A. , Kiseleva Yana Y. , Krat Alexey V. , Slepov Eugene V. , Bukatin Anton S. , Zukov Ruslan A. , Shesternya Pavel A. , Berezovski Maxim V. , Giangrande Paloma H. , Kichkailo Anna S. 
Published: June 2023

Introduction: Breast cancer (BC) diagnostics lack noninvasive methods and procedures for screening and monitoring disease dynamics. Admitted CellSearch® is used for fluid biopsy and capture of circulating tumor cells of only epithelial origin. Here we describe an RNA aptamer (MDA231) for detecting BC cells in clinical samples, including blood. The MDA231 aptamer was originally selected against triple-negative breast cancer cell line MDA-MB-231 using cell-SELEX.Methods: The aptamer structure in solution was predicted using mFold program and molecular dynamic simulations. The affinity and specificity of the evolved aptamers were evaluated by flow cytometry and laser scanning microscopy on clinical tissues from breast cancer patients. CTCs were isolated form the patients’ blood using the developed method of aptamer-based magnetic separation. Breast cancer origin of CTCs was confirmed by cytological, RT-qPCR and Immunocytochemical analyses.Results: MDA231 can specifically recognize breast cancer cells in surgically resected tissues from patients with different molecular subtypes: triple-negative, Luminal A, and Luminal B, but not in benign tumors, lung cancer, glial tumor and healthy epithelial from lungs and breast. This RNA aptamer can identify cancer cells in complex cellular environments, including tumor biopsies (e.g., tumor tissues vs. margins) and clinical blood samples (e.g., circulating tumor cells). Breast cancer origin of the aptamer-based magnetically separated CTCs has been proved by immunocytochemistry and mammaglobin mRNA expression.Discussion: We suggest a simple, minimally-invasive breast cancer diagnostic method based on non-epithelial MDA231 aptamer-specific magnetic isolation of circulating tumor cells. Isolated cells are intact and can be utilized for molecular diagnostics purposes.
A primary Rosai-Dorfman-Destombes disease of the scalp: case report and literature review
Authors: Song Wenxiong , Ding Feiyu , Xiao Yong , Hu Xinhua , Yang Kun , Geng Liangyuan , Zou Yuanjie 
Published: June 2023

BackgroundRosai-Dorfman-Destombes disease (RDD) was first described in 1965 as a benign histiocytic proliferative disorder of unknown cause. Cases of RDD limited to cutaneous tissue have been reported over the past few decades, but single cutaneous RDD of the scalp is rare.Case presentationWe report a 31-year-old male with a lump on the parietal scalp without extranodal lesion lasting 1 month with gradual enlargement. The surgical incision ruptured with purulent after the first resection. Then the patient was treated with plastic surgery after disinfection and antibiotic treatment. Finally, he recovered well and discharged after 20 days.ConclusionsRDD of the scalp is rare. Surgical incision can cure the lesion but it may become infected because of increased lymphocytic infiltration. Early diagnosis and differential diagnosis of RDD are necessary. For treatment, individualized therapy is critical to patient prognosis.
Altered regional brain activity and functional connectivity in resting-state brain networks associated with psychological erectile dysfunction
Authors: Liu Xue , Liu Shaowei , Liu Tao , Tang Liang , Ji Mufan , Xu Yan , Xiang Ziliang , Zhou Jianwen , Chen Yun , Chen Jianhuai 
Published: June 2023

IntroductionErectile dysfunction (ED), especially psychological ED (pED), is usually accompanied with psychological factors, which are related to abnormal activity in brain regions involved in sexual behavior. However, the mechanisms underlying functional changes in the brain of pED are still unclear. The present study aimed to explore the abnormalities of brain function, as well as their relationships with sexual behavior and emotion in pED patients.Materials and methodsResting state functional magnetic resonance imaging (rs-fMRI) data were collected from 31 pED patients to 31 healthy controls (HCs). The values of amplitude of fractional amplitude of low-frequency fluctuation (fALFF) and functional connectivity (FC) were calculated and compared between groups. In addition, the associations between abnormal brain regions and clinical features were evaluated by Pearson correlation analyses.ResultsCompared to HCs, pED patients demonstrated decreased fALFF values in the left medial superior frontal gyrus (had decreased FC values with the left dorsolateral superior frontal gyrus), the left lingual gyrus (had decreased FC values with the left parahippocamal gyrus and insula), the left putamen (had decreased FC values with the right caudate) and the right putamen (had decreased FC values with the left putamen and the right caudate). The fALFF values of the left medial superior frontal gyrus were negatively correlated with the fifth item scores of International Index of Erectile Function (IIEF-5). Negative relationships were found between fALFF values of the left putamen and the second item scores of Arizona Sexual Scale (ASEX). FC values between the right putamen and caudate were negatively related to the state scores of State-Trait Anxiety Inventory (STAI-S).ConclusionAltered brain function were found in the medial superior frontal gyrus and caudate-putamen of pED patients, which were associated with sexual function and psychological condition. These findings provided new insights into the central pathological mechanisms of pED.