bluuebunny/crossref_metadata_2025_split huggingface dataset:
Wood Snoezelen. Multisensory Wooden Environments for the Care and Rehabilitation of People with Severe and Very Severe Cognitive Disabilities
Authors: Tonetti Agata , Rossetti Massimo 
Published: June 2023

AbstractThe paper wants to present the progress of a research project focused on the study and design of a Snoezelen room made with wooden components. “Snoezelen” refers to closed environments capable of stimulating the senses in people with severe intellectual disabilities and non-self-sufficient people. Within these environments, multisensory stimulation takes place through various equipment and instruments such as optical fibers, water-powered light columns, systems for the reproduction of sounds or vibrations, and materials with different surface treatments. Many studies and researches have demonstrated the effectiveness of multisensory stimulation generated within a Snoezelen environment on children with autism spectrum disorder, and how this has led to beneficial effects such as the reduction in aggressive and/or self-injurious behaviors. The increase and diffusion of these environments, especially in schools, could lead to both an increase in the number of students who can undertake a rehabilitation process, and an increase in the sensory-perceptive aids available to the school. The rehabilitation and multisensory aspect of the Snoezelen methodology is, in this context, emphasized by the use of wood, thanks to its beneficial properties in terms of healthiness, comfort, and influences on psychological aspects. The goal of the research is the design of a wooden Snoezelen environment, the drafting of guidelines for its implementation, and an evaluation schedule for its use. In particular, the environment will be made by applying construction techniques in wood as a material for cladding, finishing, and components of the interior environment.
Environmental Attributes for Healthcare Professional’s Well-Being
Authors: Hammouni Zakia , Wittich Walter 
Published: June 2023

AbstractThe COVID-19 pandemic has been stressful for everyone and even more so for hard-working healthcare professionals. Contemporary hospitals are now endowed with environmental attributes that contribute to achieving well-being within their environment. However, these attributes tend to be focused on the patient and their experience. This paper examines these issues and describes the attributes of the physical environment that support healthcare professional’s well-being. Within a constructivist approach, the study was conducted in two care units in a mega hospital in Canada, before the arrival of the COVID-19 pandemic. Data collection includes a spatial evaluation of these care units, healthcare professionals’ spatial behavior, and 44 semi-structured interviews with various healthcare professionals, completed by the mental images. Thematic analysis and triangulation of the data set were conducted. Key attributes identified as promoting healthcare professionals’ well-being include light-color in care units, corridors and public areas of the hospital, and the cleanliness and art elements. Furthermore, panoramic views from the staff lounge, corridors, or elevator lobbies provide access to daylighting. This study highlights the importance of providing healthcare professionals break areas that allow them to find respite, particularly during periods of extreme stress such as COVID-19 pandemic.
Competition and Change in the Discourse on Abortion in Taiwan
Authors: Yang Chia-Ling 
Published: June 2023

AbstractWomen in Taiwan first gained the right to abortion in 1986 under the Eugenic Health Law. Although this allowed abortion under certain circumstances, abortion is otherwise still deemed a criminal act under the Penal Code.Following Myra Marx Ferree’s analysis of discourses on abortion in the USA and Germany, and based on Foucault’s theories on discourse and Fraser’s analysis of competing counterpublics, this chapter analyses the competition of discourses over three decades between the women’s movement and the religious or conservative countermovement in relation to the revision of abortion law in Taiwan.This chapter demonstrates how rhetorics about birth control/the birth rate have been strategically used by both sides within various social contexts. I will also analyse how feminist discourses have developed over the decades and how rhetorics of ‘for women’s sake’ or the employment of ‘international experiences’ are used by both sides, especially during the proposals for constraint on women’s right to abortion in the last two years.This chapter will also highlight how the progress of the women’s movement and LGBTQI rights in Taiwan create a more supportive view on women’s bodily rights and also make the conservative religious groups intensify political mobilisation from the countermovement.
Italy’s Foetus Cemeteries: Reproductive Justice, Anti-gender Stances and Neo-Catholicism
Authors: Ibba Alessia 
Published: June 2023

AbstractIn Italy, all aborted foetuses are required to be buried. However, this practice was contested when thousands of foetuses’ graves were found, each marked with a cross and displaying the name of the person who had aborted. This chapter aims to analyse the practice of the burial of aborted foetuses as an obstacle to reproductive justice in Italy, in the context of anti-genderism and neo-Catholicism contributing to shaping pro-life stances. Moreover, this study explores three threats to reproductive justice: firstly, the possibility open to health professionals to conscientiously object; secondly, the limited use of medical abortion; and thirdly, the limitations established by the law concerning assisted reproductive services. These threats are employed as a background to understand pro-life actions in this context. Findings suggest that the Catholic Church influences discussions on reproductive rights on several levels, including regarding the burial of aborted foetuses. Despite the relevance of this topic in the current sociopolitical framework, the lack of attention paid to it in academia presents this study with some limitations. For this reason, more research is needed.
Accelerating Unruh-DeWitt detectors coupled with a spinor field
Authors: Wu Dawei , Tang Shan-Chang , Shi Yu 
Published: June 2023

Abstract
The behavior of accelerating Unruh-DeWitt detectors coupled with a spinor field in (3+1)-dimensional spacetime is investigated. For a single point-like detector with Gaussian switching function, the transition probability increases with the acceleration and thus the antiUnruh effect effect cannot occur. Due to the spinor structure of the Dirac field, UV divergences are encountered in the calculation of the entanglement between the detectors. After introducing some UV cutoff Λ, the negativity of detectors is shown to behave nonmonotonically with respect to the acceleration. Besides, the negativity increases with the cutoff Λ and decreases with the distance between the detectors. The mutual information between the two detectors is also discussed.
High degree of alignment precision associated with total knee arthroplasty performed using a surgical robot or handheld navigation
Authors: Shen Tony S. , Uppstrom Tyler J. , Walker Paul J. , Yu Jonathan S. , Cheng Ryan , Mayman David J. , Jerabek Seth A. , Ast Michael P. 
Published: June 2023

AbstractPurposeThe purpose of this study was to compare the precision of bony resections during total knee arthroplasty (TKA) performed using different computer‐assisted technologies.MethodsPatients who underwent a primary TKA using an imageless accelerometer‐based handheld navigation system (KneeAlign2®, OrthAlign Inc.) or computed tomography‐based large‐console surgical robot (Mako®, Stryker Corp.) from 2017 to 2020 were retrospectively reviewed. Templated alignment targets and demographic data were collected. Coronal plane alignment of the femoral and tibial components and tibial slope were measured on postoperative radiographs. Patients with excessive flexion or rotation preventing accurate measurement were excluded.ResultsA total of 240 patients who underwent TKA using either a handheld (n = 120) or robotic (n = 120) system were included. There were no statistically significant differences in age, sex, and BMI between groups. A small but statistically significant difference in the precision of the distal femoral resection was observed between the handheld and robotic cohorts (1.5° vs. 1.1° difference between templated and measured alignments, p = 0.024), though this is likely clinically insignificant. There were no significant differences in the precision of the tibial resection between the handheld and robotic groups (coronal plane 0.9° vs. 1.0°, n.s.; sagittal plane 1.2° vs. 1.1°, n.s.). There were no significant differences in the rate of overall precision between cohorts (n.s.).ConclusionsA high degree of component alignment precision was observed for both imageless handheld navigation and CT‐based robotic cohorts. Surgeons considering options for computer‐assisted TKA should take other important factors, including surgical principles, templating software, ligament balancing, intraoperative adjustability, equipment logistics, and cost, into account.Level of evidenceIII.
Conductive vial electromembrane extraction of opioids from oral fluid
Authors: Skaalvik Tonje Gottenberg , Zhou Chen , Øiestad Elisabeth Leere , Hegstad Solfrid , Trones Roger , Pedersen-Bjergaard Stig 
Published: June 2023

AbstractThe use of oral fluid as sample matrix has gained significance in the analysis of drugs of abuse due to its non-invasive nature. In this study, the 13 opioids morphine, oxycodone, codeine, O-desmethyl tramadol, ethylmorphine, tramadol, pethidine, ketobemidone, buprenorphine, fentanyl, cyclopropylfentanyl, etonitazepyne, and methadone were extracted from oral fluid using electromembrane extraction based on conductive vials prior to analysis with ultra-high performance liquid chromatography–tandem mass spectrometry. Oral fluid was collected using Quantisal collection kits. By applying voltage, target analytes were extracted from oral fluid samples diluted with 0.1% formic acid, across a liquid membrane and into a 300 μL 0.1% (v/v) formic acid solution. The liquid membrane comprised 8 μL membrane solvent immobilized in the pores of a flat porous polypropylene membrane. The membrane solvent was a mixture of 6-methylcoumarin, thymol, and 2-nitrophenyloctyl ether. The composition of the membrane solvent was found to be the most important parameter to achieve simultaneous extraction of all target opioids, which had predicted log P values in the range from 0.7 to 5.0. The method was validated in accordance to the guidelines by the European Medical Agency with satisfactory results. Intra- and inter-day precision and bias were within guideline limits of ± 15% for 12 of 13 compounds. Extraction recoveries ranged from 39 to 104% (CV ≤ 23%). Internal standard normalized matrix effects were in the range from 88 to 103% (CV ≤ 5%). Quantitative results of authentic oral fluid samples were in accordance with a routine screening method, and external quality control samples for both hydrophilic and lipophilic compounds were within acceptable limits.
Comparison of diffusion weighted imaging b0 with T2*-weighted gradient echo or susceptibility weighted imaging for intracranial hemorrhage detection after reperfusion therapy for ischemic stroke
Authors: Luijten Sven P. R. , van der Ende Nadinda A. M. , Cornelissen Sandra A. P. , Kluijtmans Leo , van Hattem Antonius , Lycklama a Nijeholt Geert , Postma Alida A. , Bokkers Reinoud P. H. , Thomassen Lars , Waje-Andreassen Ulrike , Logallo Nicola , Bracard Serge , Gory Benjamin , Roozenbeek Bob , Dippel Diederik W. J. , van der Lugt Aad 
Published: June 2023

Abstract
Purpose
Diffusion-weighted imaging (DWI) b0 may be able to substitute T2*-weighted gradient echo (GRE) or susceptibility-weighted imaging (SWI) in case of comparable detection of intracranial hemorrhage (ICH), thereby reducing MRI examination time. We evaluated the diagnostic accuracy of DWI b0 compared to T2*GRE or SWI for detection of ICH after reperfusion therapy for ischemic stroke.

Methods
We pooled 300 follow-up MRI scans acquired within 1 week after reperfusion therapy. Six neuroradiologists each rated DWI images (b0 and b1000; b0 as index test) of 100 patients and, after a minimum of 4 weeks, T2*GRE or SWI images (reference standard) paired with DWI images of the same patients. Readers assessed the presence of ICH (yes/no) and type of ICH according to the Heidelberg Bleeding Classification. We determined the sensitivity and specificity of DWI b0 for detection of any ICH, and the sensitivity for detection of hemorrhagic infarction (HI1 & HI2) and parenchymal hematoma (PH1 & PH2).

Results
We analyzed 277 scans of ischemic stroke patients with complete image series and sufficient image quality (median age 65 years [interquartile range, 54–75], 158 [57%] men). For detection of any ICH on DWI b0, the sensitivity was 62% (95% CI: 50–76) and specificity 96% (95% CI: 93–99). The sensitivity of DWI b0 was 52% (95% CI: 28–68) for detection of hemorrhagic infarction and 84% (95% CI: 70–92) for parenchymal hematoma.

Conclusion
DWI b0 is inferior for detection of ICH compared to T2*GRE/SWI, especially for smaller and more subtle hemorrhages. Follow-up MRI protocols should include T2*GRE/SWI for detection of ICH after reperfusion therapy.
In vitro and in vivo characterization of [64Cu][Cu(elesclomol)] as a novel theranostic agent for hypoxic solid tumors
Authors: Liu Tengzhi , Dahle Maria Aanesland , Lystad Mathilde Hirsum , Marignol Laure , Karlsen Morten , Redalen Kathrine Røe 
Published: June 2023

Abstract

Purpose
Hypoxic tumors are associated with therapy resistance and poor cancer prognosis, but methods to detect and counter tumor hypoxia remain insufficient. Our purpose was to investigate 64Cu(II)-elesclomol ([64Cu][Cu(ES)]) as a novel theranostic agent for hypoxic tumors, by implementing an improved production method and assessing its therapeutic and diagnostic potential compared to the established Cu-64 radiopharmaceuticals [64Cu]CuCl2 and [diacetyl-bis(N4-methylthiosemicarbazone) [64Cu][Cu(ATSM)].

Methods
Cu-64 was produced using a biomedical cyclotron at 12 MeV with the reaction 64Ni(p,n)64Cu, followed by synthesis of [64Cu]CuCl2, [64Cu][Cu(ATSM)], and [64Cu][Cu(ES)]. In vitro therapeutic effects were assessed in both normoxic and hypoxic cells (22Rv1 and PC3 prostate cancer cells, and U-87MG glioblastoma cells) using the clonogenic assay and analyzing cellular uptake and internalization. In vivo therapeutic effects were assessed in 22Rv1 xenografts in BALB/cAnN-Foxn1nu/nu/Rj mice receiving a single or multiple doses of radiopharmaceutical, before their feasibility to detect tumor hypoxia was assessed by positron emission tomography (PET) in 22Rv1 and U-87MG xenografts.

Results
In vitro and in vivo studies demonstrated that [64Cu][Cu(ES)] reduced cell survival and inhibited tumor growth more effectively than [64Cu][Cu(ATSM)] and [64Cu]CuCl2. Hypoxia increased the cellular uptake and internalization of [64Cu][Cu(ES)] and [64Cu][Cu(ATSM)]. [64Cu][Cu(ES)]-PET tumor hypoxia detection was feasible and also revealed an unexpected finding of uptake in the brain.

Conclusion
To the best of our knowledge, this is the first time that ES is radiolabeled with [64Cu]CuCl2 to [64Cu][Cu(ES)]. We demonstrated superior therapeutic effects of [64Cu][Cu(ES)] compared to [64Cu][Cu(ATSM)] and [64Cu]CuCl2 and that [64Cu][Cu(ES)]-PET is feasible. [64Cu][Cu(ES)] is a promising theranostic agent for hypoxic solid tumors.
Strukturierte digitale Transformation von Lernen und Lehren
Authors: von der Heyde Markus , Hartmann Andreas 
Published: June 2023

ZusammenfassungDie Digitalisierung der Prozesse an Hochschulen wird in den kommenden Jahren eher an Intensität zunehmen als abnehmen. Die Vernetzung von Informationen über viele Bereiche der Hochschule hinweg erfordert neben den technischen Schnittstellen zunächst eine richtige Gliederung der Informationen im Sinne der Modellierung und Abstraktion des zu gestaltenden Gegenstands. Das Higher Education Reference Model (HERM) bildet dazu eine ideale Grundlage. Die zur Digitalisierung erforderliche Weiterentwicklung des Student Life Cycle als Bezugsmodell wird in diesem Beitrag auf eine Verschränkung von mehreren Wertströmen vorgeschlagen. Dabei werden die Fähigkeiten aus der Gestaltung des Bildungsangebots, dem Lebenszyklus der Studierenden und aus der resultierenden Schnittmenge des Studiums in ein Gesamtmodell eingeordnet. In vier Szenarien werden die erforderlichen, aber heute noch selten anzutreffenden Verschränkungen der Informationsflüsse illustriert.
Characterization of hippocampal sclerosis of aging and its association with other neuropathologic changes and cognitive deficits in the oldest-old
Authors: Sordo Lorena , Qian Tianchen , Bukhari Syed A. , Nguyen Katelynn M. , Woodworth Davis C. , Head Elizabeth , Kawas Claudia H. , Corrada María M. , Montine Thomas J. , Sajjadi S. Ahmad 
Published: June 2023

AbstractHippocampal sclerosis of aging (HS-A) is a common age-related neuropathological lesion characterized by neuronal loss and astrogliosis in subiculum and CA1 subfield of hippocampus. HS-A is associated with cognitive decline that mimics Alzheimer’s disease. Pathological diagnosis of HS-A is traditionally binary based on presence/absence of the lesion. We compared this traditional measure against our novel quantitative measure for studying the relationship between HS-A and other neuropathologies and cognitive impairment. We included 409 participants from The 90+ study with neuropathological examination and longitudinal neuropsychological assessments. In those with HS-A, we examined digitized H&E and LFB stained hippocampal slides. The length of HS-A in each subfield of hippocampus and subiculum, each further divided into three subregions, was measured using Aperio eSlide Manager. For each subregion, the proportion affected by HS-A was calculated. Using regression models, both traditional/binary and quantitative measures were used to study the relationship between HS-A and other neuropathological changes and cognitive outcomes. HS-A was present in 48 (12%) of participants and was always focal, primarily affecting CA1 (73%), followed by subiculum (9%); overlapping pathology (subiculum and CA1) affected 18% of individuals. HS-A was more common in the left (82%) than the right (25%) hemisphere and was bilateral in 7% of participants. HS-A traditional/binary assessment was associated with limbic-predominant age-related TDP-43 encephalopathy (LATE-NC; OR = 3.45, p < 0.001) and aging-related tau astrogliopathy (ARTAG; OR = 2.72, p = 0.008). In contrast, our quantitative approach showed associations between the proportion of HS-A (CA1/subiculum/combined) and LATE-NC (p = 0.001) and arteriolosclerosis (p = 0.005). While traditional binary assessment of HS-A was associated with impaired memory (OR = 2.60, p = 0.007), calculations (OR = 2.16, p = 0.027), and orientation (OR = 3.56, p < 0.001), our quantitative approach revealed additional associations with impairments in language (OR = 1.33, p = 0.018) and visuospatial domains (OR = 1.37, p = 0.006). Our novel quantitative method revealed associations between HS-A and vascular pathologies and impairment in cognitive domains that were not detected using traditional/binary measures.
Data-driven and uncertainty-aware robust airstrip surface estimation
Authors: Crocetti Francesco , Fravolini Mario Luca , Costante Gabriele , Valigi Paolo 
Published: June 2023

AbstractThe performances of aircraft braking control systems are strongly influenced by the tire friction force experienced during the braking phase. The availability of an accurate estimate of the current airstrip characteristics is a recognized issue for developing optimized braking control schemes. The study presented in this paper is focused on the robust online estimation of the airstrip characteristics from sensory data usually available on an aircraft. In order to capture the nonlinear dependency of the current best slip on sequential slip-friction measurements acquired during the braking maneuver, multilayer perceptron (MLP) approximators have been proposed. The MLP training is based on a synthetic data set derived from a widely used tire–road friction model. In order to achieve robust predictions, MLP architectures based on the drop-out mechanism have been applied not only in the offline training phase but also during the braking. This allowed to online compute a confidence interval measure for best friction estimate that has been exploited to refine the estimation via Kalman Filtering. Open loop and closed loop simulation studies in 15 representative airstrip scenarios (with multiple surface transitions) have been performed to evaluate the performance of the proposed robust estimation method in terms of estimation error, aircraft braking distance, and time, together with a quantitative comparison with a state-of-the-art benchmark approach.
Fracture blisters: predictors for time to definitive fixation in pilon fractures
Authors: Korrapati Avinaash , Ta Canhnghi N. , Mitchell Brendon C. , Wall Pelle V. , Gurusamy Pradyumna , Dwight Kathryn , Girard Paul J. , Schwartz Alexandra K. , Kent William T. 
Published: June 2023

Abstract
Purpose
Fracture blisters, a common soft-tissue complication of pilon fractures, are associated with post-operative wound infections, delays in definitive fixation, and alterations in surgical plan. The purpose of this study was to (1) identify the delay in surgery attributable to the presence fracture blisters and (2) investigate the relationship of fracture blisters to comorbidities and fracture severity.

Methods
Patients with pilon fractures at an urban level 1 Trauma center from 2010 to 2021 were identified. The presence or absence of fracture blisters was noted, along with location. Demographic information, time from injury to external fixator placement, and time to definitive open reduction internal fixation (ORIF) were collected. Pilon fractures were classified according to AO/OTA guidelines using CT imaging and plain radiographs.

Results
314 patients with pilon fractures were available for analysis, eighty (25%) of whom were found to have fracture blisters. Patients with fracture blisters had longer time to surgery compared to those without fracture blisters (14.2 days vs 7.9 days, p < 0.001). A greater proportion of patients with fracture blisters had AO/OTA 43C fracture patterns, compared with those without fracture blisters (71.3% vs 53.8%, p = 0.03). Fractures blisters were less likely to be localized over the posterior ankle (12%, p = 0.007).

Conclusion
The presence of fracture blisters in pilon fractures are associated with significant delays in time to definitive fixation and higher energy fracture patterns. Fracture blisters are less commonly located over the posterior ankle which may support the implementation of a staged posterolateral approach when managing these injures.