bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical utility of markerless motion capture for kinematic evaluation of sit-to-stand during 30s-CST at one year post total knee arthroplasty: a retrospective study
Authors: Onitsuka Katsuya , Kubota Keisuke , Yokoyama Moeka , Miyazawa Taku , Hamaguchi Toyohiro , Taniguchi Hiroto , Usuki Naohiro , Miyamoto Satoshi , Okazaki Ken , Murata Kenji , Kanemura Naohiko 
Published: December 2022

Abstract
Background
Although the importance of kinematic evaluation of the sit-to-stand (STS) test of total knee arthroplasty (TKA) patients is clear, there have been no reports analyzing STS during the 30-second chair sit-up test (30s-CST) with a focus on kinematic characteristics. This study aimed to demonstrate the clinical utility of kinematic analysis of STS during the 30s-CST by classifying STS into subgroups based on kinematic parameters, and to determine whether differences in clinical outcomes are expressed as differences in clinical outcomes.
Methods
The subjects were all patients who underwent unilateral TKA due to osteoarthritis of the knee and were followed up for one year postoperatively. Forty-eight kinematic parameters were calculated using markerless motion capture by cutting STS at the 30s-CST. The principal components of the kinematic parameters were extracted and grouped by kinematic characteristics based on the principal component scores. Clinical significance was examined by testing whether differences in patient-reported outcome measures (PROMs) were observed.
Results
Five principal components were extracted from the 48 kinematic parameters of STS and classified into three subgroups (SGs) according to their kinematic characteristics. It was suggested that SG2, with kinematic characteristics similar to the momentum transfer strategy shown in previous studies, performed better in PROMs and, in particular, may be significantly closer to obtaining the “forgotten joint”, which is considered the ultimate goal after TKA.
Conclusions
Clinical outcomes differed according to kinematic differences in STS, suggesting that kinematic analysis of STS in 30s-CST may be useful in clinical practice.
Trial registration:
This study was approved by the Medical Ethical Committee of the Tokyo Women’s Medical University (approval number: 5628 on May 21, 2021).
Prognostic Factors for the Efficacy of Infliximab in Patients with Luminal Fistulizing Crohn’s Disease
Authors: Ma Ye , Zhang Runfeng , Liu Wei , Sun Yinghao , Li Jingnan , Yang Hong , Lv Hong , Li Yue , Tan Bei , Sun Xiyu , Qian Jiaming , Li Ji 
Published: December 2022

Abstract
Background
Enteric fistula is one of the penetrating features in Crohn’s disease (CD). This study aimed to clarify the prognostic factors for the efficacy of infliximab (IFX) treatment in luminal fistulizing CD patients.
Methods
We retrospectively included 26 cases diagnosed with luminal fistulizing CD hospitalized in our medical center from 2013 to 2021. The median follow-up time was 17.5 months (range 6–124 months). The primary outcome of our research was defined as death from all causes and undergoing of any relevant abdominal surgery. Kaplan-Meier survival curves were used to describe overall survival. Univariate and multivariate analyses were used to identify prognostic factors. A nomogram was constructed and internal validation was performed using C-index.
Results
The 1- and 2-year surgery-free survival rates were 68.1% and 63.2%, respectively. In the univariate analysis, the efficacy of IFX treatment at 6 months after initiation (P < 0.001, HR 0.23, 95% CI 0.01–0.72) and the existence of complex fistula (P = 0.047, HR 4.11, 95% CI 1.01–16.71) was found significantly related to the overall surgery-free survival, while disease activity at baseline (P = 0.099) also showed predictive potential. The multivariate analysis showed that efficacy at 6 months (P = 0.010) was an independent prognostic factor. A predictive nomogram was developed and validated. The C-index for the internal validation was 0.923 (P < 0.001).
Conclusion
Nomogram including the existence of complex fistula, disease activity at baseline and efficacy of IFX at 6 months may be useful to predict long-term outcome of luminal fistulizing CD patients.
Structural delineation of SARS-CoV-2 broadly neutralizing antibody to Omicron subvariants including BA.4/BA.5 and BA.2.75
Authors: Moriyama Saya , Anraku Yuki , Taminishi Shunta , Adachi Yu , Kuroda Daisuke , Kita Shunsuke , Higuchi Yusuke , Kotaki Ryutaro , Tonouchi Keisuke , Yumoto Kohei , Suzuki Tateki , Someya Taiyou , Fukuhara Hideo , Kuroda Yudai , Yamamoto Tsukasa , Onodera Taishi , Fukushi Shuetsu , Maeda Ken , Nakamura-Uchiyama Fukumi , Hashiguchi Takao , Hoshino Atsushi , Maenaka Katsumi , Takahashi Yoshimasa 
Published: December 2022

Abstract
SARS-CoV-2 Omicron subvariants have evolved to evade receptor-binding site (RBS) antibodies that exist in diverse individuals as public antibody clones. We rationally selected RBS antibodies resilient to mutations in emerging Omicron subvariants. Y489 was identified as a site of virus vulnerability and a common footprint of broadly neutralizing antibodies against the subvariants. Multiple Y489-binding antibodies were encoded by public clonotypes and additionally recognized F486, potentially accounting for the emergence of Omicron subvariants harboring the F486V mutation. However, a subclass of antibodies broadly neutralized BA.4/BA.5 variants via hydrophobic binding sites of rare clonotypes along with extremely high mutation-resilience under escape mutation screening. The structural basis for mutation-resilience of this antibody group may inform the design of therapeutics resistant to viral escape.
Stabilization of rock slopes by anchor based on upper bound analysis incorporating Hoek-Brown failure criterion
Authors: Showkati Alan , Sharafisafab Mansour 
Published: December 2022

Abstract
In this paper, Hoek-Brown (HB) failure criterion in combination with kinematic approach of limit analysis is employed to develop an upper bound solution to the factor of safety (FoS) of an anchor-reinforced rock slope. The shear strength reduction method is adopted to define FoS by using an approach based on the parametric form of the HB shear envelope. Two ways to incorporate the non-linear HB criterion into limit analysis are considered: the tangential technique and the equivalent Mohr-Coulomb parameters method. Two objective functions are accordingly derived by equating the rates of external works done by rock weight and anchor force to the internal energy dissipation rate. Then, an optimization scheme is programmed in Matlab to capture an upper bound to the slope FoS by trying all kinematically admissible failure mechanisms. The numerical results show that the proposed solutions agree very well with other approaches including the limit equilibrium method and numerical simulations. However, despite its convenience, the equivalent method generally overestimates FoS by about 5.9% when compared to the tangential technique, meaning that it should be used with some degree of prudence. The effects of the anchor position and its horizontal inclination on the slope FoS are also discussed.
Higher Local Ebola Incidence Causes Lower Child Vaccination Rates
Authors: Das Upasak , Fielding David 
Published: December 2022

Abstract
The 2014–2016 Ebola epidemic in Guinea, Liberia, and Sierra Leone degraded healthcare services, killed healthcare professionals, disrupted the economy, and reduced trust in modern healthcare. Using data from household surveys before and after the epidemic, we show that there has been at least one long-term consequence of these effects. Overall rates of vaccination for BCG, DPT, measles, and polio are lower in Guinean and Sierra Leonean districts that had a relatively high incidence of Ebola; statistical analysis indicates that this is a causal effect. The effects of the epidemic on access to healthcare have been local effects, at least in part.
Effects of Spatial Patterning within Working Pine Forests on Priority Avian Species in Mississippi
Authors: Sklarczyk Craig A. , Evans Kristine O. , Greene Daniel U. , Morin Dana J. , Iglay Raymond B. 
Published: December 2022

Abstract
Context
Within dynamic ecosystems, research into how land use changes and patterns affect species diversity has led to a suite of ecological hypotheses to assess species-landscape associations. The Habitat Amount Hypothesis suggests that it is the total amount of habitat, regardless of configuration, whereas the Multi-dimensional Hypothesis suggests it is the suite of local, landscape, and landform characteristics that have the greatest influence on species diversity within its local landscape.
Objectives
Our study aims to understand how landscape pattern influences species abundance, in the context of these two competing hypotheses on the priority avian species.
Methods
To examine these competing hypotheses, we assessed avian species associations with total amount vs. configuration of habitat in working loblolly pine (Pinus taeda) forests in Mississippi during 2019-2020.
Results
We found that habitat amount alone did not exhibit consistent positive associations with avian abundance for both early-successional and mature forest associated species guilds. Most target species exhibited positive associations with patch proximity, measured by Euclidean distance, and proximity-area index. Associations with landform features generally had positive influences on early-successional species than mature-pine priority species.
Conclusions
Given the extensive coverage of working forests and growing demand for forest products, sustainable forestry guidelines that consider proximity of stands in similar age classes and stages could enhance landscape suitability for some target species guilds. Further research is needed to assess potential effects of stand proximity to species diversity across scales. By combining ecological theory with forest management, we can better inform conservation measures and land use objectives in working forested landscapes.
Implantation of core tract autologous bone into decompressed lesion in the core decompression for osteonecrosis of the femoral head
Authors: Yoon Jae Youn , Im Gun-Il 
Published: December 2022

Abstract
Introduction
Core decompression (CD) is a treatment modality used to prevent progression of subchondral collapse and arthritic change in osteonecrosis of the femoral head (ONFH). This study aimed to evaluate the outcomes of CD with autologous bone graft to promote rapid bone formation and early postoperative ambulation.
Methods
This study included 13 patients who received CD for ONFH (≤ 2mm head collapse) with a minimum follow-up of two years. We implanted autologous bone blocks obtained from the decompression tract into the decompressed necrotic area, and the remaining space was filled with 5–10 cc of allograft bone chips or left empty. We then evaluated patients’ clinical and radiographical outcomes.
Results
The mean visual analog scale improved from 4.7 at admission to 3.1 at the latest follow-up (P = 0.039). The mean modified Harris hip score also improved from 59.8 to 73.2 ( P = 0.027). Mild osteoarthritic changes were noted in most patients (11/13, 84.6%), and the hip survival rate (no further surgeries required) was 76.9%. Three patients underwent total hip arthroplasty due to residual hip pain (mean time to reoperation, 12.7 months).
Conclusion
Core decompression showed favorable clinical outcomes without any surgery-related complications. This technique may be recommended for the treatment of ONFH.
A computational assessment of the interaction of 5Fluorouracil (5FU) drug connected to B 12 P 12 and ScB 11 P 12 nanocages with adenine nucleobase: DFT, AIM, TD-DFT study
Authors: Rezaei-Sameti M. , Rezaei A. 
Published: December 2022

AbstractIntelligent transfer of drugs to target cells is one of the important challenges in pharmaceuticals and disease treatment. Based on this, various investigations have been done on the interaction of drugs with different materials and compounds, among which nanomaterials have received more attention due to their wide active surface. In this context, the interaction of 5Fluorouracil (5FU) drug connected B12P12and ScB11P12nanocages with the adenine nucleobase is investigated. The results of this study could provide a new idea about the effect of nanocages on drug binding to nucleobase. The computational studied base on the density functional theory at the ωB97XD/6-31G (d, p) level of theory is fulfilled in presence of a static electric field (SEF) in the z-direction (z + 0.01, z + 0.02, z + 0.03, and z + 0.04 au). The outcomes of this study confirm that the interaction of 5FU&B12P12and 5FU&ScB11P12complexes with adenine is exothermic and favorable. The electrical localized field (ELF) plots, quantum theory of atom in molecule (QTAIM) outputs, and reduced density gradient (RDG) scatter plots have been computed and results are analyzed. The output results demonstrated that the nature of bonding between 5FU&B12P12, and 5FU&ScB11P12complexes with adenine is electrostatic type. The results of this study recommended that the doping Sc atom and electrical field application increase the interaction of 5FU-drug&B12P12nanocage with adenine and it is an efficient system for 5FU drug delivery toward target cells.
A comparative study using improved LSTM /GRU for human action recognition
Authors: Muhamad Azhee Wria , Mohammed Aree Ali 
Published: December 2022

Abstract
One of the deep learning algorithms for sequence data analysis is a recurrent neural network (RNN). In a conventional neural network, the inputs and the outputs are independent of each other. At the same time, RNN is considered a type of Neural Network where the output from the previous step feeds information to the current phase. It has many applications, including video sentiment classification, speech tagging, and machine translation. Recurrent networks are also distributed parameters across each layer of the network. Several layers are stacked together to increase depth in forwarding and backward information of long short-term memory (LSTM) and Gated Recurrent Unit (GRU). This paper proposes two models for various action recognitions using LSTM and GRU, respectively. The first model was improved by increasing the LSTM layers to four and the number of units in each layer to 128 cells. While in the second model, GRU layers were extended to two layers with 128 cells, and the (update and reset) gates are modified based on the previous and current input. A comparative study was conducted during the experimental tests performed on the UCF101 action dataset regarding the accuracy rate for both models. Test results indicate that the accuracy has a significant improvement compared with other state-of-the-arts action recognitions, which are 95.19% and 92.9% for both improved LSTM and GRU, respectively.
A case report on Legg Calve-Perthes disease in a 12 years old
Authors: Prajapati Manthan Hitesh , Patel Tanvi , Rathod Mrudangsinh , Mistry Mansi 
Published: December 2022

Abstract
Introduction
Perthes disease also called as Legg Calve-Perthes disease which is a rare childhood disease that affects hip bone. It is more common in boys than girls. It occurs in the age group of 5-10 years. The cause is idiopathic, but persistent ischemia is a fictional cause. A child may present symptoms like hip pain, limping while walking, Pain radiation to the knee or hip stiffness. Blood flow to the femoral head is interrupted in one or several recurring episodes. It is also known that without therapy, complete revascularization of the avascular epiphysis occurs virtually over time within 2 to 4 years.
Case Presentation
Patient was having hip pain and groin pain for 6 months. Radiological findings suggest avascular necrosis and collapsed head of the right femur.
Conclusion:
After surgical management patient was stable, follow-up at the end of 2 months positive as the patient was symptomless and pain free with slight limp while walking.
Role of High-temperature Requirement Serine Protease A 2 in Rheumatoid Inflammation
Authors: Jeong Gi Heon , Nam Min-Kyung , Hur Wonhee , Heo Seolhee , Lee Saseong , Choi Eunbyeol , Park Jae Hyung , Park Youngjae , Kim Wan-UK , Rhim Hyangshuk , Yoo Seung-Ah 
Published: December 2022

Abstract
Background
High-temperature requirement serine protease A 2 (HtrA2) is known to be involved in growth, unfolded protein response to stress, and apoptosis or autophagy. However, whether HtrA2 controls inflammation and immune response remains elusive.
Results
Here, we found that the concentration of HtrA2 was elevated in rheumatoid arthritis (RA) synovial fluid (SF) than in osteoarthritis (OA) SF, and its concentrations were correlated with immune cells counts in the RA SF. Strikingly, in the SF of RA patients, HtrA2 levels were elevated in proportion to synovitis severity and correlated with proinflammation cytokines and chemokines, such as IL-8, IL-6 and CCL2. Of note, HtrA2 was highly expressed in RA synoviums and primary synoviocytes. RA synoviocytes released HtrA2 when stimulated by ER stress inducers. Moreover, knockdown of HtrA2 inhibited IL1β-, TNFα- or LPS-induced release of proinflammatory cytokine and chemokine by RA synoviocytes.
Conclusion
HtrA2 is a novel inflammatory mediator and therefore a promising target for developing an anti-inflammation therapy for RA.
Site-specific assessment of spinal radiographic progression improves detection of TNF blocker-associated disease modification in axial spondyloarthritis: Longitudinal observational data from the Swiss Clinical Quality Management Registry
Authors: Popova Vjara , Kissling Seraphina , Micheroli Raphael , Bräm René , de Hooge Manouk , Baraliakos Xenofon , Nissen Michael J. , Möller Burkhard , Exer Pascale , Andor Michael , Distler Oliver , Scherer Almut , Ospelt Caroline , Ciurea Adrian 
Published: December 2022

Abstract
Objectives
To analyse whether time-varying treatment with tumor necrosis factor inhibitors (TNFi) in radiographic axial spondyloarthritis (r-axSpA) has a differential impact on structural damage progression on different spinal segments (cervical versus lumbar spine).
Methods
Patients with r-axSpA in the Swiss Clinical Quality Management cohort were included if cervical and lumbar radiographs were available at intervals of 2 years for a maximum of 10 years. Paired radiographs were scored by two calibrated readers according to the modified Stoke Ankylosing Spondylitis Spine Score (mSASSS). The relationship between TNFi use and progression in the cervical and the lumbar spine was analysed using generalised estimating equation models and adjustment for potential confounding. Radiographic progression per spinal segment was defined as an increase of ≥ 1 mSASSS unit or by the formation of ≥ 1 new syndesmophyte over 2 years.
Results
Mean ± SD symptom duration was 13.8 ± 9.8 years. Mean ± SD mSASSS progression per radiographic interval was 0.41 ± 1.69 units in the cervical spine and 0.45 ± 1.45 units in the lumbar spine (p = 0.66). Prior use of TNFi significantly reduced the odds of progression in the cervical spine by 68% (OR 0.32, 95% CI 0.14–0.72), but not in the lumbar spine (OR 0.99, 95% CI 0.52–1.88). A more restricted inhibition of progression in the lumbar spine was confirmed after multiple imputation of missing covariate data (OR 0.43, 95% CI 0.24–0.77 and 0.85, 95% CI 0.51–1.41, for the cervical and lumbar spine, respectively). It was also confirmed with progression defined as formation of ≥ 1 syndesmophyte (OR 0.31, 95% CI 0.12–0.80 versus OR 0.56, 95% CI 0.26–1.24 for the cervical and lumbar spine, respectively).
Conclusion
Disease modification by treatment with TNFi seems to more profoundly affect the cervical spine in this r-axSpA population with longstanding disease. Site-specific analysis of spinal progression might, therefore, improve detection of disease modification in clinical trials in axSpA.
The effect of claudin-15 deletion on cationic selectivity and transport of paracellular pathways in the cecum and large intestine
Authors: Hempstock Wendy , Nagata Nozomi , Ishizuka Noriko , Hayashi Hisayoshi 
Published: December 2022

Abstract
The large intestine plays a pivotal role in water and electrolyte balance. It is thought that paracellular transport plays a role in water and ion transport mechanisms in the cecum and large intestine, however, these mechanisms and the physiological roles have rarely been studied. Claudin-15 forms a Na+ channel in tight junctions in the small intestine but its role in the cecum and colon has not been investigated. This study aimed to explore physiological roles of claudin-15 in the mouse cecum and colon using claudin-15 (Cldn15) KO mice. Transmural electrical conductance, current, flux of Na+, and dilution potential were assessed in isolated preparations of cecum and colon from Cldn15 KO mice mounted in Ussing chambers. The induced current of short-chain fatty acids, which are fermentative products in the cecum and colon, was also measured. In the cecum but not the middle large intestine, electrical conductance and paracellular Na+ flux were decreased, while in both the cecum and the colon, paracellular Na+ permeability was decreased in Cldn15 KO mice. These results suggest that claudin-15 is the molecule responsible for cation selectivity in tight junctions of the cecum and colon, and decreased cation selectivity in the cecum may cause impaired absorption function.
Incorporation of fine root detritus into forest soil organic matter
Authors: Fahey Timothy J , Yavitt J.B. , Goebel Marc , Pipes Gwendolyn 
Published: December 2022

Abstract
Forest soils contain a large proportion of the global carbon stock in the form of relatively stable soil organic matter (SOM). One of the principal inputs of carbon to forest SOM is turnover of tree fine roots, but the process of decomposition of fine root litter and its conversion into stable SOM has received limited study. We labeled fine roots of sugar maple (Acer saccharum Marsh.) with 13C and traced the label for seven years into four contrasting soils to improve understanding of this process. After seven years we recovered an average of 8.9% of the 13C label, with about two-thirds recovered as coarse particulate organic matter (cPOM) and one-third as fine POM (fPOM) and mineral-associated organic matter (MAOM). No differences in 13C recovery were detected between 1-2 and 3-4 order fine roots. Most of the 13C in fPOM in microaggregates (53-250 µm, 58%) was occluded within macroaggregates, and the recovery increased significantly from year 2 to 7, illustrating the role of fine root detritus in the formation of microaggregates. This process was most pronounced in the A horizon of a higher pH soil (pH = 5.5) with high iron oxide content. Conversely, the lowest 13C recovery in this fraction was observed in the A horizon of an acidic, fine-textured Inceptisol. Despite the difference between leaf litter and fine root litter in terms of placement on versus within mineral soil, patterns of their contribution to MAOM appear to be similar. Our results support recent evidence that fine root litter is a modest contributor to stable SOM in acid forest soils.