bluuebunny/crossref_metadata_2025_split huggingface dataset:
Shift work disorder, mental health and burnout among nurses: A cross‐sectional study
Authors: Cheng Hui , Liu Guangbi , Yang Junyi , Wang Qiaohong , Yang Hui 
Published: December 2022

AbstractAimThe aim of the study was to examine the relationships among nurses' shift work disorder, mental health and burnout to inform efforts to alleviate shift work disorder.DesignThis cross‐sectional study was conducted in China using a web‐based platform for questionnaire.MethodsThe study was comprised of a convenience sample of 1,268 Registered Nurses from 21 public hospitals in mainland China from June 2019–July 2019. Participants completed a web‐based survey designed to collect demographic and other self‐reported data. An independent sample t test and Pearson correlation were performed to analyse the relationship between shift work disorder, mental health and burnout.ResultsThe vast majority (98.2%) of the participants were women between the ages of 20–59 years. The participants exhibited a higher incidence of mental health problems (58.1%) and burnout (65.5%) and those with shift work disorder exhibited a higher risk of mental health problems and burnout than those who did not have shift work disorder. Our research demonstrated that shift work disorder, combined with other variables, accounted for 40.5% of the variance in mental health (R2 = .405, adjusted R2 = .401, F = 107.214, p < .001) and 36.5% in burnout (R2 = .365, adjusted R2 = .361, F = 90.323, p < .001). Moreover, burnout negatively regulated the relationship between shift work disorder and mental health.ConclusionHigh‐risk nurses with shift work disorder were at a much higher risk of mental health problems and burnout.
Psychosocial and emotional morbidities after a diagnosis of cancer: Qualitative evidence from healthcare professional cancer patients
Authors: Natuhwera Germans , Ellis Peter , Wilson Acuda Stanley , Namukwaya Elizabeth 
Published: December 2022

AbstractAimThis inquiry aimed to; (1) examine the psychosocial and emotional sequelae associated with cancer patient‐hood experience in healthcare professionals (HCPs) in Uganda, (2) generate evidence to inform clinical and nursing practice about the needs of HCP patients with cancer.DesignThis was a qualitative phenomenological study.MethodsThe study was conducted among HCP cancer patients and survivors recruited from oncology and palliative care settings in Uganda. Data were collected via audio‐taped, face‐to‐face or telephone open‐ended interviews. Interviews were transcribed verbatim. Thematic analysis was used.ResultsEight HCP cancer patients and survivors participated in the study. Their mean age was 56 years, range 29–85 years. Three major themes emerged: (1) From a healthcare provider to a patient, (2) Socioeconomic challenges, and (3) Coping and support strategies.
Convergence and error estimation of weighted finite volume scheme for coagulation‐fragmentation equation
Authors: Bariwal Sanjiv Kumar , Kumar Rajesh 
Published: December 2022

AbstractThis article is dedicated to analyze a finite volume scheme for solving coagulation and multiple fragmentation equation. The rates of coagulation and fragmentation are chosen locally bounded and unbounded (singularity near the origin), respectively. It is shown that using weak compactness method, the numerically approximated solution tends to the weak solution of the continuous problem under a stability condition on the time step for non‐uniform mesh. Further, considering a uniform mesh, first order error approximation is demonstrated when kernels are in space. The accuracy of the scheme is also authenticated numerically for several test problems.
Association between precarious employment and BMI in the United States
Authors: Oddo Vanessa M. , Zhuang Castiel Chen , Dugan Jerome A. , Andrea Sarah B. , Hajat Anjum , Peckham Trevor , Jones‐Smith Jessica C. 
Published: December 2022

AbstractObjectiveThere is growing recognition that precarious employment is an important determinant of health, which may increase BMI through multiple mechanisms, including stress. It was investigated whether increases in precarious employment were associated with changes in BMI in the United States.MethodsData were from the National Longitudinal Survey of Youth adult cohort (1996–2016) (N = 7280). Thirteen indicators were identified to operationalize seven dimensions of precarious employment (range: 0–7, 7 indicating most precarious): material rewards, working‐time arrangements, stability, workers' rights, collective organization, interpersonal relationships, and training. The precarious employment–BMI association was estimated using linear regression models and an instrumental variables approach; state‐ and individual‐level firm sizes were the instruments for precarious employment. Models also included individual and year fixed effects and controlled for age, marital status, education, region, and industry.ResultsThe average precarious employment score (PES) was 3.49 (95% CI: 3.46–3.52). The PES was the highest among Hispanic (4.04; 95% CI: 3.92–4.15) and non‐Hispanic Black (4.02; 95% CI: 3.92–4.12) women with lower education. A 1‐point increase in the PES was associated with a 2.18‐point increase in BMI (95% CI: 0.30–4.01).ConclusionsGiven that even small changes in weight affect chronic disease risk, policies to improve employment quality warrant consideration.
Fat content in infant mesenchymal stem cells prospectively associates with childhood adiposity and fasting glucose
Authors: Gyllenhammer Lauren E. , Duensing Allison M. , Keleher Madeline Rose , Kechris Katerina , Dabelea Dana , Boyle Kristen E. 
Published: December 2022

AbstractObjectiveIn human studies, new model systems are needed for improved mechanistic investigation of developmental predisposition for metabolic disease but also to serve as benchmarks in early life prevention or intervention efforts. In this regard, human infant umbilical cord–derived mesenchymal stem cells (MSCs) are an emerging tool. However, long‐term clinical relevance to in vivo markers of metabolic disease is unknown.MethodsIn a cohort of 124 mother/child dyads, this study tested the hypothesis that triglyceride content (TG) of infant MSCs undergoing adipogenesis in vitro (MSC‐TG) is associated with in vivo adiposity (percent fat mass) from birth to early childhood and with fasting glucose and insulin in early childhood.ResultsMSC‐TG was positively associated with in vivo child adiposity at birth, age 4 to 6 months, and age 4 to 6 years. MSC‐TG was associated with fasting glucose, but not insulin, at 4 to 6 years. Importantly, MSC‐TG explained an additional 13% variance in child adiposity at 4 to 6 years, after accounting for other established birth predictors (weight and percent fat mass at birth) and other established covariates related to child adiposity (e.g., breastfeeding exposure, physical activity).ConclusionsThis work demonstrates the strength of the MSC model for predicting offspring metabolic phenotype into childhood, even when considering the important contribution of other early life risk factors.
Postmenopausal women's experiences of weight maintenance following a very low energy diet
Authors: Harper Claudia , Maher Judith , Hsu Michelle , Grunseit Anne , Seimon Radhika , Sainsbury Amanda 
Published: December 2022

AbstractIntroductionVery low energy diets (VLEDs) effectively induce substantial weight loss in people with obesity, yet they are rarely used as a first line treatment. There is a belief that such diets do not teach the lifestyle behavior changes needed for long‐term weight maintenance. However, little is known about the lived experiences of people who have lost weight on a VLED in the long term.MethodsThis study aimed to explore the behaviors and experiences of postmenopausal women who had followed a 4‐month VLED (using total meal replacement products [MRPs]), followed by a food‐based, moderately energy‐restricted diet for an additional 8 months, as part of the TEMPO Diet Trial. Qualitative in‐depth semi‐structured interviews were conducted with 15 participants at 12 or 24 months (i.e., at 8 or 20 months post diet completion). Transcribed interviews were analyzed thematically using an inductive approach.ResultsUndertaking a VLED was reported by participants to confer advantages in weight maintenance that previous weight loss attempts had not been able to do for them. Firstly, the rapid and significant weight loss, in conjunction with ease of use, was motivational and helped instill confidence in the participants. Secondly, the cessation of a normal diet during the VLED was reported by participants to break weight gain‐inducing habits, allowing them to abandon unhelpful habits and to introduce in their place more appropriate attitudes toward weight maintenance. Lastly, the new identity, helpful habits and increased self‐efficacy around weight loss supported participants during weight maintenance. Additionally, participants reported that ongoing occasional use of MRPs provided a useful and easy new strategy for countering weight regain and supporting their weight maintenance regimen.ConclusionAmong the participants in this qualitative study, most of whom had maintained a loss of over 10% of their baseline body weight at the time of interview, using a VLED in the context of a clinical weight loss trial conferred confidence, motivation and skills for weight maintenance. These findings indicate that VLEDs with clinical support could be successfully leveraged to set up behaviors that will support weight maintenance in the long term.
Advancing gastric cancer precision medicine with novel genomic screens†
Authors: Halmai Nicole B , Carvajal‐Carmona Luis G 
Published: December 2022

AbstractA recent study published in The Journal of Pathology used an shRNA library targeting all known human genes involved in metabolism to identify genes important for gastric cancer. The screen identified aspartyl‐tRNA synthetase (DARS) as a potential drug target, and patients whose tumors had high DARS levels had a worse prognosis, particularly among diffuse‐type gastric cancer. These findings identify a potential therapeutic target for precision medicine of gastric cancer patients, and may be useful for further investigations to discover additional interacting targets. © 2022 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland.
DFT study of oxidation mechanism of secnidazole as an emerging contaminant: Application as STI control
Authors: Bibi Shamsa , Saleem Aamna , ur Rehman Shafiq , Bhatti Ijaz Ahmad , Iqbal Muhammad Adnan , Bashir Shahid , Quan Bai Fu , Nadeem Raziya 
Published: December 2022

AbstractA well‐known process, called the advanced oxidation process, has been effectively used to study the oxidation mechanism of pharmaceutical wastes. The strong reactivity of hydroxyl radicals used in this process gradually oxidizes organic molecules into nontoxic products. Hence, the mechanistic details of secnidazole, 1‐(2‐hydroxypropy1)‐2‐methy1‐5‐nitroimidazole, oxidation, promoted by •OH have been studied under the M06‐2X method and 6‐311 G (d,p) level of theory, using density functional theory. Secnidazole molecule has been decomposed by oxidation of the isopropanol to an –COOH group, resulting in (2‐methyl‐5‐nitro‐imidazol‐1‐yl) acetic acid, which is further oxidized to (5‐hydroxy‐2‐methylimidazol‐1‐yl) acetic acid, by the action of •OH. Furthermore, nitro and methyl groups present as substituents to the five‐membered ring are replaced by hydroxyl groups, forming 1‐(2‐hydroxypropyl)‐2‐methyl‐1H‐imidazol‐5‐ol and 1‐(2‐hydroxypropyl)‐5‐nitro‐1H‐imidazol‐2‐ol, respectively. The optimized geometries of intermediates, transition states, and free energy surfaces have been found valuable in interpreting the details of the elimination mechanism. Fukui functional analysis has disclosed the reactivities of each site of SNZ. The systematic calculations on initial products and intermediates have shown significant exothermic properties.
Staff perspectives on the key elements to successful rapid uptake of telerehabilitation in medium‐sized public hospital physiotherapy departments
Authors: Ross Megan H. , Nelson Mark , Parravicini Vicki , Weight Matthew , Tyrrell Ryan , Hartley Nicole , Russell Trevor 
Published: December 2022

AbstractBackground and purposeDuring the COVID‐19 pandemic, hospital physiotherapy departments transitioned to telerehabilitation to ensure continuity of care for patients. The purpose of this study is to determine the key elements to successful, rapid uptake of telerehabilitation in medium‐sized public hospital physiotherapy departments in response to COVID‐19.MethodsThis study used a qualitative design. Physiotherapists who delivered telerehabilitation consultations during the COVID‐19 restriction period in two Brisbane public hospital physiotherapy departments were eligible to participate in semi‐structured interviews. Data were analysed thematically.ResultsTwenty‐five physiotherapists (22–60 years of age; 68% female) with 1–40 years of clinical experience provided insights into their perceptions of the rapid uptake of telerehabilitation in the provision of clinical care. Physiotherapists worked across musculoskeletal outpatient (72%), inpatient, community, paediatrics and pelvic health departments. Qualitative analyses in relation to the physiotherapist perceptions of the key elements of rapid transition to telerehabilitation, revealed four key themes underpinning success: (1) ‘it requires a whole team approach’, (2) ‘technology issues will be encountered and can be overcome’, (3) ‘optimise the situation while understanding the differences’ and (4) ‘modifying your approach doesn't imply inferior quality of care’.ConclusionRapid implementation of telerehabilitation in a hospital setting is possible, and is facilitated by organisational, administrative and management support, willingness of physiotherapists to adopt, shared learning experience, quality software and connection, availability of equipment and space and optimised systems and processes. Key factors facilitating successful telerehabilitation consultations include effective communication, demonstration, involving a third party to help, and clients who are well prepared and willing to engage.
Dissecting the general mechanisms of protein cage self‐assembly by coarse‐grained simulations
Authors: Su Zhaoqian , Wu Yinghao 
Published: December 2022

AbstractThe development of artificial protein cages has recently gained massive attention due to their promising application prospect as novel delivery vehicles for therapeutics. These nanoparticles are formed through a process called self‐assembly, in which individual subunits spontaneously arrange into highly ordered patterns via non‐covalent but specific interactions. Therefore, the first step toward the design of novel engineered protein cages is to understand the general mechanisms of their self‐assembling dynamics. Here we have developed a new computational method to tackle this problem. Our method is based on a coarse‐grained model and a diffusion–reaction simulation algorithm. Using a tetrahedral cage as test model, we showed that self‐assembly of protein cage requires of a seeding process in which specific configurations of kinetic intermediate states are identified. We further found that there is a critical concentration to trigger self‐assembly of protein cages. This critical concentration allows that cages can only be successfully assembled under a persistently high concentration. Additionally, phase diagram of self‐assembly has been constructed by systematically testing the model across a wide range of binding parameters. Finally, our simulations demonstrated the importance of protein's structural flexibility in regulating the dynamics of cage assembly. In summary, this study throws lights on the general principles underlying self‐assembly of large cage‐like protein complexes and thus provides insights to design new nanomaterials.
Distribution and solvent exposure of Hsp70 chaperone binding sites across the Escherichia coli proteome
Authors: Chen Xi , Hutchinson Rachel B. , Cavagnero Silvia 
Published: December 2022

AbstractMany proteins must interact with molecular chaperones to achieve their native state in the cell. Yet, how chaperone binding‐site characteristics affect the folding process is poorly understood. The ubiquitous Hsp70 chaperone system prevents client‐protein aggregation by holding unfolded conformations and by unfolding misfolded states. Hsp70 binding sites of client proteins comprise a nonpolar core surrounded by positively charged residues. However, a detailed analysis of Hsp70 binding sites on a proteome‐wide scale is still lacking. Further, it is not known whether proteins undergo some degree of folding while chaperone bound. Here, we begin to address the above questions by identifying Hsp70 binding sites in 2258 Escherichia coli (E. coli) proteins. We find that most proteins bear at least one Hsp70 binding site and that the number of Hsp70 binding sites is directly proportional to protein size. Aggregation propensity upon release from the ribosome correlates with number of Hsp70 binding sites only in the case of large proteins. Interestingly, Hsp70 binding sites are more solvent‐exposed than other nonpolar sites, in protein native states. Our findings show that the majority of E. coli proteins are systematically enabled to interact with Hsp70 even if this interaction only takes place during a fraction of the protein lifetime. In addition, our data suggest that some conformational sampling may take place within Hsp70‐bound states, due to the solvent exposure of some chaperone binding sites in native proteins. In all, we propose that Hsp70‐chaperone‐binding traits have evolved to favor Hsp70‐assisted protein folding devoid of aggregation.
Molecular dynamics studies of CED‐4/CED‐9/EGL‐1 ternary complex reveal CED‐4 release mechanism in the linear apoptotic pathway of Caenorhabditis elegans
Authors: Reddy C. Narendra , Sankararamakrishnan Ramasubbu 
Published: December 2022

AbstractMany steps in programmed cell death are evolutionarily conserved across different species. The Caenorhabditis elegans proteins CED‐9, CED‐4 and EGL‐1 involved in apoptosis are respectively homologous to anti‐apoptotic Bcl‐2 proteins, Apaf‐1 and the “BH3‐only” pro‐apototic proteins in mammals. In the linear apoptotic pathway of C. elegans, EGL‐1 binding to CED‐9 leads to the release of CED‐4 from CED‐9/CED‐4 complex. The molecular events leading to this process are not clearly elucidated. While the structures of CED‐9 apo, CED‐9/EGL‐1 and CED‐9/CED‐4 complexes are known, the CED‐9/CED‐4/EGL‐1 ternary complex structure is not yet determined. In this work, we modeled this ternary complex and performed molecular dynamics simulations of six different systems involving CED‐9. CED‐9 displays differential dynamics depending upon whether it is bound to CED‐4 and/or EGL‐1. CED‐4 exists as an asymmetric dimer (CED4a and CED4b) in CED‐9/CED‐4 complex. CED‐4a exhibits higher conformational flexibility when simulated without CED‐4b. Principal Component Analysis revealed that the direction of CED‐4a's winged‐helix domain motion differs in the ternary complex. Upon EGL‐1 binding, majority of non‐covalent interactions involving CARD domain in the CED‐4a‐CED‐9 interface have weakened and only half of the contacts found in the crystal structure between α/β domain of CED4a and CED‐9 are found to be stable. Additional stable contacts in the ternary complex and differential dynamics indicate that winged‐helix domain may play a key role in CED‐4a's dissociation from CED‐9. This study has provided a molecular level understanding of potential intermediate states that are likely to occur when CED‐4a is released from CED‐9.
Decentralized iterative learning control for constrained collaborative tracking
Authors: Chen Bin , Chu Bing 
Published: December 2022

ABSTRACTHigh performance collaborative tracking where multiple subsystems work together repetitively to track a reference has found applications in various areas. To meet the high accuracy requirements, iterative learning control (ILC) has recently been used. However, most existing designs ignore the system constraints that are often encountered in practice. Furthermore, they usually have a centralized structure (or controller parameter) that needs to be redesigned or re‐tuned when the system changes which may cause difficulties for handling large scale systems. In this article, we consider the constrained collaborative tracking problem and propose a novel constrained ILC design. The resulting ILC algorithm guarantees not only the satisfaction of the system constraints, but also the monotonic convergence of the collaborative tracking error norm to a minimum (possible) value. We further develop a decentralized implementation of the proposed algorithm using the alternating direction method of multipliers, allowing the design to scale up to large scale and varying system dynamics. Finally, we provide numerical examples to verify the algorithms' effectiveness.
A unified Lyapunov characterization for finite time control and prescribed time control
Authors: Song Yongduan , Su Jie 
Published: December 2022

AbstractThis work presents a novel approach to unifying finite time control and prescribed time control. The main idea is to establish a new Lyapunov differential inequality that allows finite time and prescribed time stability to be addressed uniformly. It is shown that the derived control algorithm is able to achieve prescribed time convergence with bounded control gain and bounded control action, completely solving for the first time the long‐lasting issue of infinite gain associated with current notion of prescribed time control. Numerical simulations also confirmed the effectiveness of the developed approach.
Evaluating a driving index of nonresidential green building implementation for sustainable development in developing countries from a Vietnamese perspective
Authors: Yang Jin Kook , Thuc Le Dinh , Cuong Pham Phu , Van Du Nguyen , Tran Huu‐Bang 
Published: December 2022

AbstractThe purpose of this study is to evaluate a quantitative driving index for implementing green building in Vietnam as a case study in developing countries. Using literature review and expert interviews, 19 driving forces affecting green building implementation were identified in the Vietnamese context. Via obtained data from a questionnaire survey, four principle factors were grouped from defined drivers. The fuzzy synthetic evaluation method was utilized to develop a driving index (DI) for developing the green building in Vietnam. DI model indicated that environmental impact is the most crucial group for green building implementation in Vietnam. Apart from this, the result of the comparative analysis also indicated that most driving forces for adopting green building in developing countries related to environmental and social problems. These results provide the decision‐makers with a comprehensive tool to assess the expectations for green building implementation in both Vietnam and other developing countries.
Zinc‐bis(imino)pyridine Complexes as Catalysts for Azide‐Alkyne Cycloaddition in Water
Authors: Dey Jyotirmoy , Yadav Seema , Raj Lakshkar Ritu , Singh Ajeet , Ray Sriparna , Dash Chandrakanta 
Published: December 2022

AbstractTwo new zinc(II) complexes, [2,6‐bis(methylphenyliminomethyl)pyridine]ZnBr2 (2 a) and [2,6‐bis(triflouromethylphenyliminomethyl)pyridine]ZnBr2 (2 b) were synthesized by the reactions of corresponding 2,6‐bis(imino)pyridine based [NNN]‐pincer ligand and anhydrous ZnBr2 in acetonitrile as a solvent. The catalytic properties of zinc(II) complexes were examined in azide‐alkyne cycloaddition reactions in water. The zinc(II) complexes were characterized by UV‐Vis, 1H NMR, IR, elemental analysis and mass spectroscopy. The zinc complex [2,6‐bis(triflouromethylphenyliminomethyl)pyridine]ZnBr2 was characterized by X‐ray crystallography. The zinc(II) complexes efficiently catalyzed the azide‐alkyne cycloaddition reaction for the synthesis of 1,2,3‐triazoles (mixture of 1,4‐ and 1,5‐disubstituted 1,2,3‐triazoles) in water with good to excellent yields.