bluuebunny/crossref_metadata_2025_split huggingface dataset:
Born this way and stuck in the middle: The queer child at the center of parental conflict1
Authors: Davis Lindsey Sank , Currie Nathaniel 
Published: January 2025

AbstractWhile there is significant extant literature on lesbian, gay, bisexual, transgender, queer, and other sexual orientation and gender minority (LGBTQ+) parents and a large and growing body of research on the mental health of LGBTQ+ youth, there remains a dearth of empirical literature focused on the experiences of LGBTQ+ youth facing parental conflict, separation, and divorce. This unfortunate trend is telling as to the perceived legitimacy of LGBTQ+ identities in children and adolescents and highlights critical gaps in need of amelioration. This paper reviews and applies interdisciplinary research on LGBTQ+ youth and families, addressing complex questions raised by two de‐identified cases involving the navigation of co‐parenting conflicts surrounding a bisexual adolescent and a transgender adolescent. The literature review highlights the heightened mental health risks LGBTQ+ youth experience due to minority stress and familial rejection. The wider sociopolitical and legal contexts affecting LGBTQ+ youth and their families, including the harmful effects of anti‐LGBTQ+ legislation, are also addressed. Family court professionals are advised to take a careful multi‐perspective approach to cases involving LGBTQ+ youth and to engage in advocacy and educational efforts in their respective fields to foster inclusive and supportive psycholegal environments for LGBTQ+ families in the United States and worldwide.
Effectiveness of behavioural and psychological interventions for managing obesity in children and adolescents: A systematic review and meta‐analysis framed using minimal important difference estimates based on GRADE guidance to inform a clinical practice guideline
Authors: Henderson M. , Moore S. A. , Harnois‐Leblanc S. , Johnston B. C. , Fitzpatrick‐Lewis D. , Usman A. M. , Sherifali D. , Merdad R. , Rigsby A. M. , Esmaeilinezhad Z. , Morrison K. M. , Hamilton J. , Ball G. D. C. , Birken C. S. ,   the Steering Committee for Updating Canada's Clinical Practice Guideline for Managing Pediatric Obesity
Published: January 2025

SummaryObjectiveConduct a systematic review and meta‐analysis of randomized controlled trials (RCTs) of behavioural and psychological interventions for managing paediatric obesity.MethodsEligible studies, published between 1985 and 2022, included 0 to 18 year olds with outcomes reported ≥3 months post‐baseline, including patient‐reported outcome measures (PROMs), cardiometabolic and anthropometric outcomes, and adverse events (AEs). We pooled data using a random effects model and assessed certainty of evidence (CoE) related to minimally important difference estimates for outcomes using GRADE.ResultsWe included 73 unique RCTs (n = 6305 participants, 53% female). Intervention types included physical activity (n = 1437), nutrition (n = 447), psychological (n = 1336), technology‐based (n = 901) or multicomponent (≥2 intervention types, n = 2184). Physical activity had a small effect on health‐related quality of life (HRQoL), varying effects ranging from moderate to very large on blood pressure, lipids and insulin resistance, and a small effect on BMIz. Nutrition had a small effect on lipids, insulin resistance and BMIz. Psychological interventions showed a small effect on HRQoL and triglycerides and moderate benefits on depressive symptoms, while technology interventions showed small benefits on blood pressure and BMIz. Multicomponent interventions had a large benefit on anxiety, small benefit on depressive symptoms, with large to very large benefits on lipids, and small benefits for diastolic blood pressure, insulin resistance and BMIz. AEs were reported infrequently, and when reported, were described as mild.ConclusionPhysical activity and multicomponent interventions showed improvements in PROMs, cardiometabolic and anthropometric outcomes. Future trials should consistently measure PROMs, evaluate outcomes beyond the intervention period, and study children <6 years of age.
Long‐term follow‐up of the impact of brief sleep and lifestyle interventions in infancy on BMIz‐score at 11 years of age: The POI randomized controlled trial
Authors: Taylor Rachael W. , Galland Barbara C. , Heath Anne‐Louise M. , Gray Andrew R. , Meredith‐Jones Kim A. , Fortune Sarah A. , Sullivan Trudy A. , Adebowale Taiwo , McIntosh Deborah , Jackson Rosie F. , Taylor Barry J. 
Published: January 2025

SummaryObjectiveTo determine whether BMI differences observed at 5 years of age, from early intervention in infancy, remained apparent at 11 years.MethodsParticipants (n = 734) from the original randomized controlled trial (n = 802) underwent measures of body mass index (BMI), body composition (DXA), sleep and physical activity (24‐h accelerometry, questionnaire), diet (repeated 24‐h recalls), screen time (daily diaries), wellbeing (CHU‐9D, WHO‐5), and family functioning (McMaster FAD) around their 11th birthday. Following multiple imputation, regression models explored the effects of two interventions (‘Sleep’ vs. ‘Food, Activity and Breastfeeding’ [FAB]) using a 2 × 2 factorial design.ResultsFive hundred twelve children (48% female, mean [SD] age 11.1 [0.1] years) returned for the 11‐year assessment (63% of original sample). Significant differences in BMI z‐score (mean difference; 95% CI: −0.16; −0.41, 0.08) or the risk of overweight (including obesity) (odds ratio; 95% CI: 0.85; 0.56, 1.29) were no longer observed between children who had received the sleep intervention compared with those who had not. By contrast, children who had received the FAB intervention had greater BMI z‐scores (0.24; 0.01, 0.47) and a higher risk of obesity (1.56; 1.03, 2.36) than children not enrolled in FAB. No significant differences were observed in any lifestyle variables nor wellbeing measures across all groups.ConclusionsSustained reductions in BMI and obesity risk from an early sleep intervention were not apparent 9 years later, whereas a more traditional lifestyle intervention resulted in increased rates of obesity, not explained by any differences in lifestyle behaviours measured.Clinical Trial RegistryClinicalTrials.gov number NCT00892983, https://clinicaltrials.gov/study/NCT00892983.
The Potential of Poetry in Mental Health Nurse Pre‐registration Education
Authors: Pearson Mark 
Published: January 2025

ABSTRACTThis paper examines the potential of poetry as a resource within mental health nurse pre‐registration education. There has long been a debate as to whether the art or the science of nursing should be foregrounded within pre‐registration education, especially in the UK within recent years as the latest Nursing and Midwifery Council's standards of pre‐registration education appear to have shifted the focus towards the acquisition of skills, giving less consideration to the holistic transformatory process of education. The paper uses the conceptualisation of education by Beista, who proposes that education can be considered in relation to the three domains of qualification, socialisation and subjectification. Qualification refers to the acquisition of knowledge and skills, socialisation refers to the process of joining a professional group, and subjectification refers to the development of the individual as a reflective, thoughtful and responsible individual. The paper explores each of these domains in turn and considers how poetry can make a unique contribution in supporting both personal development, and the acquisition of professional knowledge and skills. The reading and writing of poetry can support students to challenge epistemic blinders, enhance their interpersonal skills and develop a more authentic professional identity.
The Second Round of a Population‐Based Seroprevalence Study of Anti–SARS‐CoV‐2 Antibodies and COVID‐19 Vaccination Assessment in the Republika Srpska, Bosnia and Herzegovina
Authors: Aćimović Jela , Mijović Biljana , Mašić Srđan , Petković Miroslav , Sladoje Dragana Puhalo , Knežević Darija , Dević Jelena Đaković , Spaić Dragan , Vladičić‐Mašić Jelena , Bokonjić Dejan , Palo Mirza , Vaughan Aisling , Pebody Richard , Nardone Anthony , Škrbić Ranko 
Published: January 2025

ABSTRACTIntroductionThe aim of the study was to assess the seroprevalence of SARS‐CoV‐2 in the Republika Srpska, Bosnia and Herzegovina, after five waves of COVID‐19 and 1 year after introduction of vaccination to better understand the true extent of the COVID‐19 pandemic in the population of the Republika Srpska and role of vaccination in achieving herd immunity.MethodsThe population‐based study was conducted from December 2021 to February 2022 in a group of 4463 individuals in the Republika Srpska. Total anti–SARS‐CoV‐2 antibodies were determined in serum specimens using the Wantai total antibody ELISA assay. Quantitative analysis, using Kantaro IgG assays, was performed in subsamples (1273 specimens) to asses and compare levels of IgG among vaccinated, recovered and participants with hybrid immunity. To adjust for age and gender distribution in sample, poststratification method is applied.ResultsThe overall cumulative seroprevalence was 94.6% (95% CI = 93.9–95.3). Significantly higher seroprevalence rates were observed among vaccinated 97.8% (95% CI = 97.3–98.4) comparing to unvaccinated participants (89.5%, 95% CI = 88.0–91.0). Seroprevalence increases with the number of received doses. Among various professions, the highest seroprevalence was found in the service industry (98.1%), education (98.0%) and healthcare (96.9%). We found that 2.2% of vaccinated and 3.6% of participants with SARS‐CoV‐2 positivity during 2021 had no detectable IgG antibodies. Both seroprevalence (98.6%) and antibody titres (1094.4 AU/mL) were significantly higher among people with hybrid immunity.ConclusionOur findings reveal a 2.3‐fold increase in seroprevalence of SARS‐CoV‐2 antibodies due to infection and vaccination, comparing to the first study performed 1 year earlier. This study provides better understanding of the SARS‐CoV‐2 transmission and highlights the important role of the vaccination in achieving the population immunity. Periodically conducted population‐based seroprevalence studies are important to understand temporal trends and assess surveillance system performance and public compliance with vaccination policies.
Atypical Atrial Flutter: Electrophysiological Characterization and Effective Catheter Ablation
Authors: Johner Nicolas , Namdar Mehdi , Shah Dipen C. 
Published: January 2025

ABSTRACTAtrial flutter (AFL), defined as macro‐re‐entrant atrial tachycardia, is associated with debilitating symptoms, stroke, heart failure, and increased mortality. AFL is classified into typical, or cavotricuspid isthmus (CTI)‐dependent, and atypical, or non‐CTI‐dependent. Atypical AFL is a heterogenous group of re‐entrant atrial tachycardias that most commonly occur in patients with prior heart surgery or catheter ablation. The ECG pattern is poorly predictive of circuit anatomy but may still provide mechanistic insight. AFL is difficult to manage medically and catheter ablation is the preferred treatment for most patients. Recent progress in technology and clinical electrophysiology has led to detailed characterization of re‐entry circuits and effective ablation strategies. Combined activation and entrainment mapping are key to identifying the re‐entry circuit. The presence of a slow‐conducting isthmus, localized re‐entry, dual‐loop re‐entry or bystander loops may lead to misleading activation maps but can be identified by electrogram examination and entrainment mapping. In the occasional patient without inducible AFL, substrate mapping in sinus rhythm may be a viable strategy. Long‐term ablation success requires the creation of a transmural continuous lesion across a critical component of the re‐entry circuit. Procedural endpoints include bidirectional conduction block across linear lesions and non‐inducibility of atrial tachycardia. The present review discusses the epidemiology, mechanisms, ECG characteristics, electrophysiological characterization, and catheter ablation of atypical AFL.
Effectiveness of a Knowledge Level of Hypertension on Blood Pressure Control, Treatment Adherence, and Physical Activity of Hypertensive Individuals
Authors: Gömleksiz Mehtap , Gömleksiz Muhammet Rıdvan , Gelen Şeyma , Uzala Emine Sena , Yakar Burkay 
Published: January 2025

ABSTRACTIndividuals' knowledge and attitudes about hypertension are important in controlling blood pressure (BP) and reducing hypertension‐related mortality and morbidity. The current study aimed to investigate the effect of hypertension knowledge level on treatment adherence, BP control, and physical activity of hypertensive individuals. This prospective and cross‐sectional study was conducted in the Family Medicine clinic of a tertiary healthcare institution between October 2023 and April 2024. The study included 218 patients with essential hypertension. The BP of all patients was measured with a calibrated mercury sphygmomanometer, and the patients were divided into two groups: uncontrolled BP and controlled BP. The Hypertension Knowledge Level Scale (HK‐LS), General Practice Physical Activity Questionnaire (GPPAQ), and Modified Morisky Medication Adherence Scale (MMMAS‐6) were administered to all participants. Although 40.8% (n = 89) of the patients had their BP under control, 59.2% (n = 129) did not. The median weight of the participants whose BP was not under control was higher than those whose BP was under control (p < 0.05). A significant positive correlation was found between the hypertension knowledge score and the Morisky total score, Morisky motivation, and Morisky knowledge scores. There was a significant negative correlation between the GPPAQ score and both systolic and diastolic BP, as well as a significant positive correlation with hypertension knowledge levels. Assessing the knowledge level of hypertensive patients about their disease, recognizing their lifestyles, and questioning their habits is crucial for recommending individualized health interventions tailored to the needs and characteristics of this population.
Identifying Drug Prescription in Newly Diagnosed Hypertension Patients in India
Authors: Alexander Thomas , Hiremath Jagdish S. , Swahney Jitendra P. S. , Chandra Subhash , Jain Peeyush , Chandra Praveen , Sinha Nakul , Sashikanth T. , Bachhu Yugandhar , Balachandran Anil , Jayagopal Pathiyil Balagopalan , Unni T. Govindan , Nair Tiny , Kannan Kumaresan , Prabhakar Dorairaj , Chenniappan M. , Mahajan Ajay U. , Karnik Rajiv D. , Ponde Chandrashekhar K. , Advani Prashant , Khan Idris Ahmed , Goyal Brij Mohan , Vaidyanathan P. R. , Prajapati Hiren , Verberk Willem J. 
Published: January 2025

ABSTRACTThis study evaluated initial antihypertensive drug prescription patterns in Indian healthcare settings. An observational, cross‐sectional, prospective prescription registry analyzed prescriptions for 4723 newly diagnosed hypertension patients. Additionally, it investigated the extent to which physicians adhered to either European or Indian hypertension guidelines. Angiotensin receptor blockers (ARBs) were the most commonly prescribed drugs, given to 79% of patients, followed by calcium channel blockers (CCBs) at 55%. Diuretics and beta‐blockers (BBs) were prescribed to 27% and 17% of patients, respectively. Monotherapy was administered to 35% of patients, while combination therapies were more prevalent, with dual therapy at 51% and regimens involving three or more drugs prescribed to 14%. Among multi‐drug treatments (n = 3082, 65%), 98% received fixed‐dose combination tablets. The most common combinations were ARB + CCB (26%), ARB + diuretic (12%), and ARB + CCB + diuretic (8%). Key predictors for an increasing number of prescribed drugs included statin use/dyslipidemia, age, blood pressure level, and diabetes. Non‐adherence to hypertension guidelines was evident as 1364 patients classified from moderate to very high risk received monotherapy. Of these, 496 patients had grade 2 or 3 hypertension. Additionally, 88 patients received the undesirable combination of ACEi + ARB, and 267 (15.9%) type 2 diabetes mellitus (T2DM) patients did not receive RAS‐blockers (146 on monotherapy). The findings reveal a trend toward utilizing ARBs, CCBs, and combination tablets, indicating improved adherence to guidelines. However, a significant number of patients did not receive appropriate treatment, highlighting areas for improvement in prescription practices.
miR‐143‐3p/TET1 Axis Regulates GPC1 Through DNA Methylation and Impairs the Malignant Biological Behaviour of HCC via the Hippo Signalling Pathway
Authors: Liu Yan , Du Di , Gu Xue , He Qing , Xiong Bin 
Published: January 2025

ABSTRACTHepatocellular carcinoma (HCC) is a malignant tumour that poses a serious threat to human health and places a heavy burden on individuals and society. However, the role of GPC1 in the malignant progression of HCC is unknown. In this study, we analysed the expression of GPC1 in HCC, and its association with poor patient prognosis. The effects of GPC1 on the proliferation, invasion and migration of HCC were analysed through cellular functional experiments in vitro and in vivo. Mechanistically, DNA methylation of GPC1 was analysed by DNA extraction, methylation‐specific PCR and bisulfite Sanger sequencing (BSP), and the target genes TET1 and miRNA regulating DNA methylation of GPC1 were found through the bioinformatics database. The results revealed that GPC1 was highly expressed in HCC, and its high expression was significantly associated with poor prognosis of HCC patients. Inhibiting the expression of GPC1 can inhibit the proliferation, invasion and migration of HCC cells. GPC1 was hypomethylated in HCC, and its methylation level was regulated by TET1. miR‐143‐3p can significantly regulated the expression of TET1 and affect the methylation level and protein expression of GPC1. Furthermore, GPC1 also affects the malignant biological behaviour of HCC by regulating the expression of Hippo signalling pathway. In summary, miR‐143‐3p regulates the expression of TET1, affects the expression of GPC1 through DNA methylation and regulates the malignant progression of HCC via Hippo signalling pathway.
Aucubin Promotes BMSCs Proliferation and Differentiation of Postmenopausal Osteoporosis Patients by Regulating Ferroptosis and BMP2 Signalling
Authors: Zheng Yang , Sun Rongtai , Yang Huan , Gu Tianyuan , Han Meichun , Yu Congcong , Chen Pengyu , Zhang Jianhua , Jiang Ting , Ding Yangyang , Liang Long , Quan Renfu , Yao Shasha , Zhao Xing 
Published: January 2025

ABSTRACTPostmenopausal osteoporosis (PMOP) is a chronic systemic bone metabolism disorder. Promotion in the patterns of human bone marrow mesenchymal stem cells (hBMSCs) differentiation towards osteoblasts contributes to alleviating osteoporosis. Aucubin, a natural compound isolated from the well‐known herbal medicine Eucommia, was previously shown to possess various pharmacological effects. However, its effects on hBMSCs of PMOP patients are unknown. The aim of this present research was to investigate the impact and underlying process of aucubin on cell proliferation and osteogenic differentiation in hBMSCs isolated from PMOP patients. The ability of aucubin to inhibit the ferroptosis induced by erastin in hBMSCs was detected; ROS production, ferrous ion levels, SOD, MDA, and GPX activities were tested by using commercial kits. Next, ALP staining, ARS staining, RT‐qPCR, RNA‐sequencing, and Western blot were applied for determining the mRNA and protein expression levels associated with the osteogenesis of hBMSCs. The study also explored the involvement of BMP2/Smads signalling in aucubin promoting the osteogenesis of hBMSCs and evaluated the effects of aucubin intervention on osteoporosis using an ovariectomised rat model. The results indicated that aucubin significantly inhibited ROS generation and oxidative stress induced by erastin and protected against ferroptosis in hBMSCs. Additionally, aucubin facilitated osteogenic differentiation of hBMSCs by activating the BMP2/SMADs pathway and attenuated the progression of osteoporosis in OVX rats, suggesting a potential therapeutic benefit for postmenopausal osteoporosis (PMOP).
Cellular Senescence Genes as Cutting‐Edge Signatures for Abdominal Aortic Aneurysm Diagnosis: Potential for Innovative Therapeutic Interventions
Authors: Zhang Shuli , Li Jiayin , Wang Ruichen , Zhao Xiaojie , Mei Zhu , Wang Xiaozeng 
Published: January 2025

ABSTRACTAbdominal aortic aneurysm (AAA) is the most prevalent dilated arterial aneurysm that poses a significant threat to older adults, but the molecular mechanisms linking senescence to AAA progression remain poorly understood. This study aims to identify cellular senescence‐related genes (SRGs) implicated in AAA development and assess their potential as therapeutic targets. Four hundred and twenty‐nine differentially expressed genes (DEGs) were identified from the GSE57691 training set, and 867 SRGs were obtained. Through the intersection of DEGs with SRGs, 19 differentially expressed senescence‐related genes (DESRGs) were uncovered. Functional enrichment analysis was performed to explore their biological roles in AAA. To identify hub genes, we applied machine learning algorithms, including LASSO, SVM‐RFE and random forest. These hub genes were then validated in two independent datasets. In the initial validation cohort, significant differences in the expression levels of BTG2, ETS1, ID1 and ITPR3 were observed between the AAA and control groups. Receiver operating characteristic (ROC) analysis demonstrated a robust diagnostic performance. Further validation across different AAA stages (small, large and ruptured AAA) identified ETS1 and ITPR3 as potential diagnostic genes. Subsequently, the diagnostic relevance of ETS1 and ITPR3 was further validated in human serum samples and mouse models of AAA. In addition, single‐cell RNA sequencing suggests that senescent endothelial cells play a pivotal role in AAA progression, we further confirmed the correlation between ETS1 and ITPR3 and senescent endothelial cells by WB, IF and RT‐qPCR. In conclusion, our study reveals the pivotal role of cellular senescence in AAA progression and identifies ETS1 and ITPR3 as promising diagnostic biomarkers.
Lay Theories of Expertise: A Mixed‐Methods Exploration
Authors: Keating Lauren A. , Walker Benjamin W. 
Published: January 2025

AbstractFailure to engage with expertise underpins many organizational and societal problems. Despite decades of research on expertise, we still do not fully understand why such failures persist, and there is a sense that these failures are becoming a crisis of expertise. In this article, we highlight a person's system of beliefs about the meaning of expertise – what we term their lay theory of expertise (LTE) – as an important factor for understanding their engagement with expertise. Through a free response study (Study 1), analysis of social media data (Study 2), and word sorting study (Study 3), we first develop a taxonomy of common LTE elements. We then examine how LTEs affect expert recognition via two experiments with managers (Studies 4 and 5). Study 4 reveals that congruence between the most psychologically active element of a person's lay theory and expert conduct is conducive to expert recognition, while Study 5 highlights that (in)congruence between LTEs and expert conduct can alter how other mental representations (such as gender stereotypes) shape expert recognition. Our work provides a conceptual foundation for exploring variation in the subjective meaning of expertise in future research on expert recognition and engagement, both within and beyond organizations.