bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development and External Validation of a Prediction Model for Quality of Life of ICU Survivors: A Subanalysis of the MONITOR-IC Prospective Cohort Study*
Authors: Porter Lucy L. , Simons Koen S. , Ramjith Jordache , Corsten Stijn , Westerhof Brigitte , Rettig Thijs C. D. , Ewalds Esther , Janssen Inge , van der Hoeven Johannes G. , van den Boogaard Mark , Zegers Marieke 
Published: February 2023

OBJECTIVES:
To develop and externally validate a prediction model for ICU survivors’ change in quality of life 1 year after ICU admission that can support ICU physicians in preparing patients for life after ICU and managing their expectations.

DESIGN:
Data from a prospective multicenter cohort study (MONITOR-IC) were used.

SETTING:
Seven hospitals in the Netherlands.

PATIENTS:
ICU survivors greater than or equal to 16 years old.

INTERVENTIONS:
None.

MEASUREMENTS AND MAIN RESULTS:
Outcome was defined as change in quality of life, measured using the EuroQol 5D questionnaire. The developed model was based on data from an academic hospital, using multivariable linear regression analysis. To assist usability, variables were selected using the least absolute shrinkage and selection operator method. External validation was executed using data of six nonacademic hospitals. Of 1,804 patients included in analysis, 1,057 patients (58.6%) were admitted to the academic hospital, and 747 patients (41.4%) were admitted to a nonacademic hospital. Forty-nine variables were entered into a linear regression model, resulting in an explained variance (R
2) of 56.6%. Only three variables, baseline quality of life, admission type, and Glasgow Coma Scale, were selected for the final model (R
2 = 52.5%). External validation showed good predictive power (R
2 = 53.2%).

CONCLUSIONS:
This study developed and externally validated a prediction model for change in quality of life 1 year after ICU admission. Due to the small number of predictors, the model is appealing for use in clinical practice, where it can be implemented to prepare patients for life after ICU. The next step is to evaluate the impact of this prediction model on outcomes and experiences of patients.
Familial clustering of intrahepatic cholestasis of pregnancy: A nationwide population-based study in Denmark
Authors: Li Jiong , Chen Jiawen , Lee Priscilla Ming Yi , Zhang Jun , Li Fei , Ren Tai 
Published: February 2023

Background and Aims:
Genetics plays a role in the pathogenesis of intrahepatic cholestasis of pregnancy (ICP); however, empirical evidence on familial clustering of ICP is scarce. We aimed to assess the extent of familial recurrence of ICP.

Approach and Results:
This population-based cohort study included all 668,461 primiparous women who gave birth between 1995 and 2018 in Denmark. Women diagnosed with ICP were included to the index cohort. Kinship with index women was determined with the Danish Civil Registration System. Log-binomial regression was used to calculate the relative recurrence risk (RRR) of ICP in relatives of index women. A total of 6722 (1.0%) primiparous women were diagnosed with ICP. In co-twins (n=57), first-degree (n=2279), second-degree (n=1373), and third-degree (n=1758) relatives of the index women, the incidence of ICP reached 5.3%, 2.6%, 0.7%, and 1.4%, respectively, corresponding to adjusted RRRs of 4.82 (95% CI, 1.60–14.48), 2.54 (1.98–3.26), 0.81 (0.44–1.51), and 1.15 (0.77–1.71), respectively. The first-degree relatives of women who had recurrent ICP or first-trimester ICP seemed to be at higher risks [RRR, 4.30 (2.85–6.48), 3.04 (1.93–4.77), respectively]. A minor increased risk was observed in nonbiological relatives [RRR, 1.35 (1.05–1.73); n=4274, including women’s full-brothers’ partner and women’s husbands’ full sisters].

Conclusions:
Co-twins and first-degree relatives of ICP patients were at ~5- and ~2.5-fold increased risk of ICP, respectively. No increased risk was observed in second-degree and third-degree relatives. Recurrent ICP and first-trimester ICP might indicate a higher degree of family clustering. Further investigation is needed to investigate the increased risk of ICP in nonbiological relatives.
Lean individuals with NAFLD have more severe liver disease and poorer clinical outcomes (NASH-CO Study)
Authors: Nabi Oumarou , Lapidus Nathanaël , Boursier Jerome , de Ledinghen Victor , Petit Jean-Michel , Kab Sofiane , Renuy Adeline , Zins Marie , Lacombe Karine , Serfaty Lawrence 
Published: February 2023

Background and Aims:
The severity of liver injury and clinical outcomes in lean individuals with NAFLD is a subject of debate and very few studies have been performed in the general population. The aim of this study was to compare subject characteristics and mortality between lean and nonlean NAFLD in a community setting.

Approach and Results:
The study population included 169,303 participants from the nationwide Constances cohort. Subjects with excessive alcohol consumption, viral hepatitis, or other liver diseases were excluded and 137,206 subjects were analyzed. The diagnosis of NAFLD and fibrosis was performed using the Fatty Liver Index and the Forns Index. The median follow-up was 3.58 years. The prevalence of NAFLD was 5.3% (95% CI: 5.2–5.4) in lean subjects, while 16.3% (95% CI: 15.7–16.8) of NAFLD subjects were lean. Despite their better metabolic profile, the prevalence of advanced fibrosis was significantly higher in lean than in nonlean NAFLD (3.7% vs. 1.7%, respectively, p < 0.01). Among NAFLD subjects and after adjustment for demographics, metabolic risk factors and lifestyle, lean status was associated with advanced fibrosis (OR=1.26, 95% CI: 1.20–1.65, p = 0.005), an increased risk of liver-related events (adjusted HR=5.84, 95% CI: 4.03–8.46), chronic kidney disease (adjusted HR=2.49, 95% CI: 1.49–4.16), and overall mortality (adjusted HR=3.01, 95% CI: 2.21–4.11). Liver-related events and overall mortality were related to the severity of fibrosis, both in lean and nonlean NAFLD subjects, whatever the usual risk factors.

Conclusion:
This study in a large community-based cohort confirms that NAFLD in lean subjects is more severe for fibrosis, the progression of liver disease, chronic kidney disease, and overall mortality.
Feasibility and Effect of Increasing Clozapine Plasma Levels in Long-Stay Patients With Treatment-Resistant Schizophrenia
Authors: Bogers Jan P.A.M. , Schulte Peter F.J. , Broekman Theo G. , de Haan Lieuwe 
Published: February 2023

Abstract

Background
It is unknown whether increasing the clozapine plasma level to 400, 750, or even 1000 ng/mL is a feasible and effective strategy in patients with treatment-resistant schizophrenia (TRS). We investigated this in long-stay patients with TRS.

Methods
In long-stay TRS patients, doses of clozapine were increased gradually to reach target plasma levels of 400, 750, or 1000 ng/mL, depending on the clinical response and tolerability. After an effective or tolerated level was reached, positive and negative syndrome scale scores were evaluated after 3 months and 1 year.

Results
Twenty-eight patients were included. Overall, 54% of the patients, and especially patients 60 years and older, could not achieve one of the clozapine target levels because of adverse effects. Three physically vulnerable patients died, probably not directly related to clozapine use. Although only 21% of patients achieved a more than 20% reduction in total symptoms at the 1-year follow-up, the mean severity of positive symptoms decreased from 18.18 to 15.10 (P < 0.01). The largest decrease in positive symptoms was seen in TRS patients who achieved a plasma level of 750 ng/mL of clozapine.

Conclusions
Most TRS patients older than 60 years could not tolerate high clozapine levels and so this should not be attempted in older or otherwise physically vulnerable patients. Increasing clozapine levels to approximately 750 ng/mL in middle-aged patients with longstanding TRS may modestly reduce the severity of positive symptoms and improve the response rate.
Pulmonary Functions and Oxidative Stress Biomarkers Among Silica-Exposed Foundry Workers
Authors: Hussein Asmaa Mohamed , Attia Dalia Ismail , Zayed Bahaa El-Din Mostafa , Rashed Laila Ahmed , EL-Sherif Ghada Hossam El-Din 
Published: February 2023

ObjectiveTo investigate the changes of the ventilatory function tests and the oxidative stress biomarkers among silica-exposed foundry workers.MethodsThe exposed group included 70 workers in an iron foundry. The nonexposed group included 40 subjects from Kasralainy outpatient clinic. Both groups were subjected to history taking, clinical examination, chest radiograph, spirometry, urinary silica, serum malondialdehyde (MDA), glutathione peroxidase (GPx), and 8-hydroxydeoxyguanosine (8-HdG).ResultsHigher urinary silica, serum MDA and serum 8-HdG, whereas lower serum GPx and ventilatory functions were detected in the exposed group compared with the controls. All parameters correlated with urinary silica. The exposed silicotic subgroup had increased work duration, urinary silica, serum MDA, and serum 8-HdG, and decreased serum GPx and ventilatory functions compared with non-silicotic subgroup.ConclusionOxidative stress biomarkers were abnormal with impairment of ventilatory functions among silica-exposed workers.
Diarrhea in the critically ill: definitions, epidemiology, risk factors and outcomes
Authors: Dionne Joanna C. , Mbuagbaw Lawrence 
Published: February 2023

Purpose of review
In this paper, we review the current evidence with respect to definitions, risk factors, and outcomes of diarrhea in the critically ill and highlight research gaps in the literature.

Recent findings
Definitions of diarrhea in the intensive care unit (ICU) include the World Health Organization quantified as >3 liquid bowel movements per day and the Bristol Stool Chart score of 7. Diarrhea incidence is 37.7–73.8% and varies based on definition applied. Clostridioides difficile associated diarrhea (CDAD) is uncommon with an incidence of 2.2%. Risk factors for diarrhea include total number of antibiotics, enteral nutrition, and suppository use. The composition of enteral nutrition including high osmolarity and high fiber feeds contributed to diarrhea occurrence. Opiates decrease diarrhea incidence whereas probiotics have no effect on the incidence or duration of diarrhea. Outcomes of diarrhea include increased length of stay in the ICU and hospital, however its impact on mortality is unclear.

Summary
Diarrhea remains a common problem in clinical practice and attention must be paid to modifiable risk factors. Further research is needed on interventions to decrease its burden.
Case report: Extravascular catheter migration in a child: A rare complication of the totally implantable venous access device
Authors: Lu Xuning , Ren Yueyi , Wan Hao , Xu Qiteng , Duan Shuhua 
Published: February 2023

Background:
Totally implantable venous access devices (TIVADs) are widely used to gain intermittent central venous access, such as in patients who need long-term chemotherapy, total parenteral nutrition, and long-term antibiotic treatment. At present, there are many complications associated with the use of these devices. Complete extravascular migration of TIVADs via the internal jugular vein is a very rare and potentially serious condition, especially in children.

Case presentation:
A 1-year-old girl needed palliative chemotherapy because of hepatoblastoma complicated by inferior vena cava thrombosis. A TIVAD was implanted through the right internal jugular vein with a routine heparin flushing tube. On the second day after the operation, a pale bloody liquid was drawn out from the device and the chest X-ray was checked to confirm that the position of the catheter was normal. On the third day after the operation, however, the patient’s right respiratory sound was weakened on physical examination and auscultation. Fluoroscopy showed that the tip of the catheter was located in the right thoracic cavity, and there was a large amount of effusion in the right thoracic cavity. The pleural effusion was removed, the TIVAD was replaced again, and the child was discharged 2 days later.

Conclusions:
Following TIVAD implantation, if abnormalities are found, in addition to chest X-ray, saline flush and echocardiography should be performed to determine the position of the catheter and rule out extravascular migration of the catheter to avoid irreparable consequences.
The impact of Teach-back method on preoperative anxiety and surgical cooperation in elderly patients undergoing outpatient ophthalmology surgery: A randomized clinical trial
Authors: Shen Dan , Huang Weiyi , Wei Shujin , Zhu Yanjun , Shi Baoxin 
Published: February 2023

Background:
The literatures have demonstrated that Teach-back method is an effective communication tool to understand health education, especially in the elderly patients. However, there is limited research of Teach-back method in preoperative education for outpatient surgical patients. This study was conducted to investigate the effects of the Teach-back method on preoperative anxiety and surgical cooperation in elderly patients undergoing outpatient ophthalmology surgery.

Methods:
One hundred sixteen elderly patients who underwent outpatient ophthalmology surgery were selected as the research objects. They were divided into the observation group (58 cases) and the control group (58 cases). The Teach-back preoperative education was adopted in the observation group and the standard preoperative education method was adopted in the control group. The degree of anxiety, surgical cooperation, and awareness of health knowledge were compared between the 2 groups, and the variations of blood pressure and heart rate, as well as the highest values of intraoperative blood pressure and heart rate before and after method, were recorded and compared.

Results:
The preoperative systolic blood pressure in the observation group was significantly lower than that in the control group. The intraoperative (the highest value) heart rate, systolic blood pressure, and diastolic blood pressure in the observation group were lower than those in the control group, and the differences were statistically significant (P < .05). After intervention, the anxiety score and information demand score of the observation group were lower than those of the control group, and the differences were statistically significant (P < .05). The degree of surgery cooperation and awareness of perioperative health knowledge in the observation group were all higher than those in the control group; the differences were statistically significant (P < .05).

Conclusion:
The Teach-back method could relieve the preoperative anxiety of the patients, improve the quality of patients surgery cooperation, and facilitate the awareness of health knowledge. Moreover, it could effectively improve the intraoperative stress response of the elderly patients and reduce the large fluctuations of blood pressure and heart rate.
Analysis of citation trends to identify articles on delirium worth reading using DDPP model with temporal heatmaps (THM): A bibliometric analysis
Authors: Ho Sam Yu-Chieh , Chien Tsair-Wei , Tsai Kang-Ting , Chou Willy 
Published: February 2023

Background:
Delirium is one of the most common geriatric syndromes in older patients, accounting for 25% of hospitalized older patients, 31 to 35% of patients in the intensive care unit, and 8% to 17% of older patients in the emergency department (ED). A number of articles have been published in the literature regarding delirium. However, it is unclear about article citations evolving in the field. This study proposed a temporal heatmap (THM) that can be applied to all bibliographical studies for a better understanding of cited articles worth reading.

Methods:
As of November 25, 2022, 11,668 abstracts published on delirium since 2013 were retrieved from the Web of Science core collection. Research achievements were measured using the CJAL score. Social network analysis was applied to examine clusters of keywords associated with core concepts of research. A THM was proposed to detect articles worth reading based on recent citations that are increasing. The 100 top-cited articles related to delirium were displayed on an impact beam plot (IBP).

Results:
The results indicate that the US (12474), Vanderbilt University (US) (634), Anesthesiology (2168), and Alessandro Morandi (Italy) (116) had the highest CJAL scores in countries, institutes, departments, and authors, respectively. Articles worthy of reading were highlighted on a THM and an IBP when an increasing trend of citations over the last 4 years was observed.

Conclusion:
The THM and IBP were proposed to highlight articles worth reading, and we recommend that more future bibliographical studies utilize the 2 visualizations and not restrict them solely to delirium-related articles in the future.
Delayed recognition of autism spectrum disorder and attention-deficit/hyperactivity disorder in a girl with ornithine transcarbamylase deficiency: A case report
Authors: Kadono Shin , Miyawaki Dai , Goto Ayako , Hirai Kaoru , Sakamoto Shoko , Hama Hiroki , Nishiura Sayaka , Hamazaki Takashi , Inoue Koki 
Published: February 2023

Rationale:Ornithine transcarbamylase (OTC) deficiency, a urea cycle disorder, is a rare congenital metabolic error that leads to hyperammonemia. Psychiatric symptoms of hyperammonemia are nonspecific and can cause autism spectrum disorder (ASD)-like symptoms and attention-deficit/hyperactivity disorder (ADHD)-like symptoms. Some studies report that OTC deficiency is often initially diagnosed as ASD or ADHD. However, there are no reports of OTC deficiency comorbid with ASD and ADHD.Patient concerns:The patient is 17-year-old girl diagnosed with OTC deficiency at 3 years of age. She had behavioral problems since childhood, including depressed mood, irritability, and impulsive behavior; however, they were considered OTC-mediated nonspecific psychiatric symptoms. Therefore, the patient had not been appropriately assessed for ASD and ADHD. She presented with depressed mood and self-harm at 17 years of age.Diagnoses:We diagnosed her with ASD and ADHD based on her medical history and semistructured interviews.Interventions:We focused her ASD and ADHD traits and discussed strategies with her for better adaptive living.Outcomes:Our interventions resulted in her better social adjustment.Lessons:Physicians should consider the possibility of comorbid ASD and ADHD in individuals with OTC, facilitating appropriate and intervention for better outcomes.
Using chord diagrams to explore article themes in 100 top-cited articles citing Hirsch’s h-index since 2005: A bibliometric analysis
Authors: Lee Yei-Soon , Chow Julie Chi , Chien Tsair-Wei , Chou Willy 
Published: February 2023

Background:
The h-index is increasingly being used as a measure of individual research achievement (IRA). More than 4876 citing articles have been published and indexed in Web of Science. The articles citing the h-index that have made the greatest contribution to scientific academics are still unknown. It is also unclear which subject categories (SCs) can be classified based on their keywords.

Methods:
These 4976 citing articles have been collected from the Web of Science since 2005. SCs were classified using chord diagrams to visualize their associations of SCs and documents in 100 top-cited articles (T100hciting). In addition to chord diagrams, 6 visualizations were used to illustrate study results: choropleth maps were used to depict the geographical distribution of publications across countries, network diagrams were created by using coword analysis, box plots were created to complement the network diagrams, Sankey diagrams highlighted the 5 most important elements in each article entity, the dot plot was used for displaying T100hciting, and a radar plot was used to present the top 10 high-IRA elements of countries, institutes, departments, and authors based on category, journal impact factor, authorship, and L-index scores.

Results:
A coword cluster analysis indicates that the majority of articles come from the US (918, 18%) and China (603, 12%), the top 2 SCs are h-index and bibliometric analysis, and the top 5 countries account for 55% in T100hciting, such as the US (25%), Spain (10%), Netherlands (9%), China (6%), and Belgium (5%). In T100hciting, 4 SCs are included, namely, the h-index (72%), bibliometric analysis (24%), physics & multidisciplinary (3%), and infectious diseases (1%).

Conclusion:
A total of 7 visualizations were used to display the results in this study. Chord diagrams are suggested as a tool for future bibliographical studies to classify SCs Future bibliometrics with chord diagrams should not be limited to the topic of h-index-citing articles, as we did in this study.
A systematic review and meta-analysis of the diagnostic value of circulating microRNA-17-5p in patients with non-small cell lung cancer
Authors: Hao Juntao , Shen Zengqiang 
Published: February 2023

Background:
nonSmall Cell Lung Cancer (NSCLC) is the most common type of lung cancer with high morbidity and mortality rates. Studies have shown that miR-17-5p levels are significantly increased in the circulating blood of NSCLC patients. This meta-analysis aimed to investigate the diagnostic value of miR-17-5p in NSCLC in China.

Methods:
A literature search was conducted for studies on the correlation between miR-25 and the diagnosis of NSCLC until October 2022 using English and Chinese databases. The Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2) was adopted to evaluate the quality of studies in the literature. Numerical values for sensitivity and specificity were obtained from false negative (FN), false positive (FP), true negative (TN), and true positive (TP) rates, presented alongside graphical representations with boxes marking the values and horizontal lines showing the confidence intervals. Summary Receiver Operating Characteristic (SROC) curves were applied to assess the performance of the diagnostic tests. The data were processed using RevMan 5.3.

Results:
Three studies (208 cases of NSCLC patients and 198 healthy controls) met our evaluation criteria. The sensitivity was 0.70 to 0.75, and the specificity value was 0.82 to 0.83. The Area Under the Curve (AUC) from the SROC curves was > 80%; therefore, it was classified as a good category.

Conclusion:
Our meta-analysis shows that miR-17-5p can be used for the diagnosis of NSCLC and may serve as a biomarker for the detection of early NSCLC in the Chinese population.