bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gluing AdS/CFT
Authors: Kawamoto Taishi , Ruan Shan-Ming , Takayanagi Tadashi 
Published: July 2023

Abstract
In this paper, we investigate gluing together two Anti-de Sitter (AdS) geometries along a timelike brane, which corresponds to coupling two brane field theories (BFTs) through gravitational interactions in the dual holographic perspective. By exploring the general conditions for this gluing process, we show that the energy stress tensors of the BFTs backreact on the dynamical metric in a manner reminiscent of the TTbar deformation. In particular, we present explicit solutions for the three-dimensional case with chiral excitations and further construct perturbative solutions with non-chiral excitations.
Counting operators in N = 1 supersymmetric gauge theories
Authors: Delgado Antonio , Martin Adam , Wang Runqing 
Published: July 2023

Abstract
Following a recent publication, in this paper we count the number of independent operators at arbitrary mass dimension in N = 1 supersymmetric gauge theories and derive their field and derivative content. This work uses Hilbert series machinery and extends a technique from our previous work on handling integration by parts redundancies to vector superfields. The method proposed here can be applied to both abelian and non-abelian gauge theories and for any set of (chiral/antichiral) matter fields. We work through detailed steps for the abelian case with single flavor chiral superfield at mass dimension eight, and provide other examples in the appendices.
T1,1 truncation on the spindle
Authors: Amariti Antonio , Petri Nicolò , Segati Alessia 
Published: July 2023

Abstract
We study the compactification of the 𝒩 = 2 AdS5 consistent truncation of the conifold, in presence of a Betti vector multiplet, on the spindle. We derive the BPS equations and solve them at the poles, computing the central charge for both the twist and the anti-twist class, turning on the magnetic charge associated to the baryonic symmetry. Then, in the anti-twist class, where there are choices of the quantized flux that give origin to a positive central charge, we numerically solve the BPS equations interpolating between the poles of the spindle. We conclude by comparing our results with the one obtained from the analysis of the dual field theory, finding an exact agreement.
The association of sociodemographic characteristics with work disability trajectories during and following long-term psychotherapy: a longitudinal register study
Authors: Selinheimo Sanna , Gluschkoff Kia , Kausto Johanna , Turunen Jarno , Koskinen Aki , Väänänen Ari 
Published: July 2023

Abstract
Purpose
This register-based study examined the trajectories of depression or anxiety disorder-related work disability during and following long-term psychotherapy and identified sociodemographic factors that indicate membership in different trajectory groups.

Methods
Data were drawn from national registers (Statistics Finland, Social Insurance Institution of Finland). Participants included a random sample of Finnish working-age individuals (18–55 years) who started psychotherapy treatment between 2011 and 2014 and were followed for 5 years: 1 year before and 4 years after the onset of psychotherapy (N = 3 605 individuals; 18 025 person-observations across five time points). Group-based trajectory modeling was applied to assign individuals to work disability trajectories by the number of annual mental health-related work disability months. Multinomial logistic regression was used to examine the associations between trajectory group membership and baseline sociodemographic factors of age, gender, occupational status, and geographical area of residence.

Results
Four mental health-related work disability trajectories were identified: stable very low (72%), decrease (11%), persistent low (9%) and persistent high (7%). Those with older age, female gender, lower occupational status, and living in sparsely populated geographical areas were more likely to belong to the most unfavorable trajectory group of persistent high work disability. The presence of multiple risk characteristics substantially increased the probability of belonging to the most adverse trajectory group.

Conclusions
Sociodemographic factors were associated with the course of mental health-related work disability in association with psychotherapy. Rehabilitative psychotherapy does not function as an equal support resource for work ability in all parts of the population.
Development and experimental verification of the new WHA sinters intended for kinetic energy projectiles
Authors: Goroch Olgierd , Gulbinowicz Zbigniew , Magier Mariusz , Bednarczyk Ewa , Skoczylas Paweł , Pankowski Zygmunt , Sweklej Pawel , Zochowski Pawel , Jedrzejewski Wieslaw 
Published: July 2023

AbstractDepleted uranium (DU) and tungsten heavy alloys (WHA) are commonly used as kinetic energy projectiles penetrators due to their excellent properties such as remarkably high density and strength which significantly affect their armor penetration capabilities. This article presents the results of laboratory and field tests of the new WHA sinter which summarize the results of a development project intended to increase the strength of the above-mentioned sinters used in the production of kinetic ammunition. The alloy with the composition W91–6Ni–3Co was used for the tests. The obtained alloy was subjected to cold swaging deformation with reduction of 25%. The parameters of individual technological processes were determined based on previous research. These studies concerned the impact of the degree of cold swaging deformation on the mechanical properties of the 91W–6Ni–3Co alloy. The above-mentioned work presents the results of UTS test, Charpy impact strength measurement, hardness and microhardness measurement, and the results of WHA microscopic observations in two states: after heat treatment and the final state after cold swaging deformation with reduction of: 25%. The next purpose of the research was to check the strength and functioning of the new WHA rods used in 120 mm sub-caliber projectiles. This examination was crucial for the completion of this research project, and its results enabled a synthesis of laboratory results and experimental tests.
On the summability and convergence of formal solutions of linear q-difference-differential equations with constant coefficients
Authors: Ichinobe Kunio , Michalik Sławomir 
Published: July 2023

AbstractWe consider the Cauchy problem for homogeneous linear q-difference-differential equations with constant coefficients. We characterise convergent, k-summable and multisummable formal power series solutions in terms of analytic continuation properties and growth estimates of the Cauchy data. We also introduce and characterise sequences preserving summability, which make a very useful tool, especially in the context of moment differential equations.
New insights into the diversity and ecology of benthic hydroids (Cnidaria, Hydrozoa) from the Ross Sea (Antarctica)
Authors: Peña Cantero Álvaro L. 
Published: July 2023

AbstractHydrozoans are recognized as one of the main and most characteristic zoological groups of the Antarctic benthos, despite the fact that there are still large Antarctic areas where the hydrozoan fauna is completely unknown or poorly known (e.g., the Admunsen Sea and Mary Byrd Land, in West Antarctica, and Queen Maud Land and Enderby Land, in East Antarctica). The present study contributes to a better understanding of the Ross Sea benthic hydroid fauna by studying material collected through several New Zealand expeditions mostly with RV Tangaroa. The Ross Sea includes the world’s largest marine-protected area (MPA) and is of considerable biological value and importance for scientific research. Although some parts of the Ross Sea shelf have been intensively sampled, others have not, including deeper parts of the continental shelf and the slope. Forty species were found, belonging to 15 families and 19 genera. Six species, including Eudendrium megaloarmatus sp. nov., Nemertesia gelida sp. nov., Schizotricha frigida sp. nov., Symplectoscyphus pseudofrondosus sp. nov. and Symplectoscyphus tortuosus sp. nov., represent new records, bringing the number of known species in the Ross Sea to 84. Leptothecata is dominant, with 35 species, while Anthoathecata is represented by five species. Symplectoscyphidae is the most diversified family with 12 species (30%), and Symplectoscyphus is the most speciose genus with nine species (23%). Three main hydroid assemblages have been found in the studied area, two with a wide bathymetric range and relatively high species diversity, and a third with a narrow and deep bathymetric range and remarkably low hydroid diversity. The hydroid fauna is dominated by species with a wide bathymetric distribution and virtually all species are restricted to Antarctic or Antarctic/sub-Antarctic waters, with 70% endemic to the Antarctic region.
A test of adaptive strategy theory using fifteen years of change in coral abundance
Authors: Kuo Chao-Yang , Pratchett Morgan S. , Madin Joshua S. , Baird Andrew H. 
Published: July 2023

AbstractUniversal Adaptive Strategy Theory aims to predict how taxa and assemblages respond to disturbances on the basis of adaptive strategy group (ASG) membership. Here, we test such predictions using the adaptive strategy scheme for reef-building corals developed by Darling et al. (Ecol Lett 15:1378–1386, 2012) and a long-term dataset of coral assemblage structure from inshore reefs on the central Great Barrier Reef. Several disturbances including mass bleaching and tropical storms were recorded in this 15-year interval from 1998 to 2013. ASG membership did not predict how a given taxon responded to disturbance. In fact, all ASGs were on average equally affected by bleaching and a period of multiple disturbances. Furthermore, there were no consistent winners at these sites in response to the 1998 bleaching in contrast to previous work suggesting clear hierarchies in susceptibility to bleaching. In conclusion, while further efforts to re-evaluate the utility of ASGs for reef corals should be encouraged our results and a re-examination of the literature suggests that direct trait-based approaches might prove more useful when exploring how corals respond to disturbance.
Evaluating the oncological safety of neoadjuvant chemotherapy in locally advanced colon carcinoma: a systematic review and meta-analysis of randomised clinical trials and propensity-matched studies
Authors: Davey Matthew G. , Amir Amira H. , Ryan Odhrán K. , Donnelly Mark , Donlon Noel E. , Regan Mark , Meshkat Babak , Nugent Emmeline , Joyce Myles , Hogan Aisling M. 
Published: July 2023

Abstract

Purpose

Use of neoadjuvant chemotherapy (NAC) for locally advanced colon cancer (LACC) remains controversial. An integrated analysis of data from high-quality studies may inform the long-term safety of NAC for this cohort. Our aim was to perform a systematic review and meta-analysis of randomised clinical trials (RCTs) and propensity-matched studies to assess the oncological safety of NAC in patients with LACC.

Methods
A systematic review was performed as per preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines. Survival was expressed as hazard ratios using time-to-effect generic inverse variance methodology, while surgical outcomes were expressed as odds ratios (ORs) using the Mantel-Haenszel method. Data analysis was performed using Review Manager version 5.4.

Results
Eight studies (4 RCTs and 4 retrospective studies) including 31,047 patients with LACC were included. Mean age was 61.0 years (range: 19–93 years) and mean follow-up was 47.6 months (range: 2–133 months). Of those receiving NAC, 4.6% achieved a pathological complete response and 90.6% achieved R0 resection (versus 85.9%, P < 0.001). At 3 years, patients receiving NAC had improved disease-free survival (DFS) (OR: 1.28, 95% confidence interval (CI): 1.02–1.60, P = 0.030) and overall survival (OS) (OR: 1.76, 95% CI: 1.10–2.81, P = 0.020). When using time-to-effect modelling, a non-significant difference was observed for DFS (HR: 0.79, 95% CI: 0.57–1.09, P = 0.150) while a significant difference in favour of NAC was observed for OS (HR: 0.75, 95% CI: 0.58–0.98, P = 0.030).

Conclusion
This study highlights the oncological safety of NAC for patients being treated with curative intent for LACC using RCT and propensity-matched studies only. These results refute current management guidelines which do not advocate for NAC to improve surgical and oncological outcomes in patients with LACC.

Trial registration
International
Prospective Register of Systematic Review (PROSPERO) registration: CRD4202341723.
Clinicopathological features and management of biliary cystic tumors of the liver: a single-center experience
Authors: El-Magd El-Sayed Abou , El-Shobari Mohamed , Abdelsalam Ramy A. , Abbas Amr , Elmahdy Youssif , Hamed Hosam 
Published: July 2023

Abstract
Background
Biliary cystic neoplasms (BCNs) of the liver are rare pathologies encountered in hepatobiliary surgeries. Till now, there is a lack of definitive criteria used to differentiate biliary cystadenoma (BCA) from biliary cystadenocarcinoma (BCAC).

Methods
In the period between 2005 and 2018, the data of consecutive patients diagnosed with BCA and BCAC were retrospectively reviewed.

Results
A total of 62 patients underwent surgical management for BCNs. BCA was diagnosed in 50 patients while 12 patients had BCAC. Old age, male gender, smoking, and abdominal pain were strongly associated with BCAC. Left lobe location, small size, with the presence of mural nodule, and solid component were significantly noticed with BCAC. A novel pre-operative score was developed to predict the susceptibility for BCAC and help us to identify the optimal surgical strategy. Blood loss, operative time, and complications were comparable between the two study groups.

Conclusion
Mural nodules or solid components are suggestive of BCAC. Complete surgical resection of cystic tumors of the liver is mandatory due to malignant potential of the lesion and for prolonged survival.
Long-read sequencing reveals the complex structure of extra dic(21;21) chromosome and its biological effects
Authors: Yoshida-Tanaka Kugui , Ikemoto Ko , Kuribayashi Ryoji , Unoki Motoko , Takano Takako , Fujimoto Akihiro 
Published: July 2023

AbstractComplex congenital chromosome abnormalities are rare but often cause severe symptoms. However, the structures and biological impacts of such abnormalities have seldomly been analyzed at the molecular level. Previously, we reported a Japanese female patient with severe developmental defects. The patient had an extra dicentric chromosome 21 (chr21) consisting of two partial chr21 copies fused together within their long arms along with two centromeres and many copy number changes. In this study, we performed whole-genome, transcriptional, and DNA methylation analyses, coupled with novel bioinformatic approaches, to reveal the complex structure of the extra chromosome and its transcriptional and epigenetic changes. Long-read sequencing accurately identified the structures of junctions related to the copy number changes in extra chr21 and suggested the mechanism of the structural changes. Our transcriptome analysis showed the overexpression of genes in extra chr21. Additionally, an allele-specific DNA methylation analysis of the long-read sequencing data suggested that the centromeric region of extra chr21 was hypermethylated, a property associated with the inactivation of one centromere in the extra chromosome. Our comprehensive analysis provides insights into the molecular mechanism underlying the generation of the extra chromosome and its pathogenic roles.
Healing of bark wounds in Norway spruce seedlings can be negatively affected by treatment with methyl jasmonate
Authors: Chen Yayuan , Björkman Christer , Bylund Helena , Björklund Niklas , Högberg Karl-Anders , Puentes Adriana 
Published: July 2023

Abstract
Key message
Treatment with methyl jasmonate can slow down the healing of stem bark wounds in Norway spruce seedlings.

Abstract
In woody plants, healing of bark wounds is a tolerance trait involved in recovery from stem damage. Yet, little is known on how wound healing may be affected by plant protection treatments such as methyl jasmonate application (MeJA, a plant hormone triggering increased resistance to pests). Here, we examined if MeJA can affect healing of an existing and a subsequently inflicted stem wound on Norway spruce (Picea abies) seedlings, the effect of treatment on plant growth, and potential trade-offs between healing and resistance to insect damage. Seedlings from 18 full-sib families were mechanically wounded (or not) on the lower stem and treated with MeJA (or water) one week after. Two months later, another wound was inflicted and wound area was measured during six months. Growth of non-wounded and wounded seedlings were compared, and correlations between family estimates of healing rates and field insect damage were examined. We found that MeJA slowed down wound healing. For the first and second wound, respectively, MeJA-treated seedlings experienced 15% and 9% slower healing rates, and wounds remained 58% and 69% larger in size compared to water-treated seedlings. Stem wounding and MeJA together were more detrimental to seedling diameter than height growth, relative to each treatment alone. Finally, resistance to field insect damage and wound healing rates were not significantly correlated. We conclude that MeJA-mediated seedling protection may trade-off with bark wound healing, which may be negative for seedling vigor. However, further studies are needed to evaluate if such effects outweigh the benefits that MeJA provides.
MOIMPA: multi-objective improved marine predators algorithm for solving multi-objective optimization problems
Authors: Hassan Mohamed H. , Daqaq Fatima , Selim Ali , Domínguez-García José Luis , Kamel Salah 
Published: July 2023

AbstractThis paper introduces a multi-objective variant of the marine predators algorithm (MPA) called the multi-objective improved marine predators algorithm (MOIMPA), which incorporates concepts from Quantum theory. By leveraging Quantum theory, the MOIMPA aims to enhance the MPA’s ability to balance between exploration and exploitation and find optimal solutions. The algorithm utilizes a concept inspired by the Schrödinger wave function to determine the position of particles in the search space. This modification improves both exploration and exploitation, resulting in enhanced performance. Additionally, the proposed MOIMPA incorporates the Pareto dominance mechanism. It stores non-dominated Pareto optimal solutions in a repository and employs a roulette wheel strategy to select solutions from the repository, considering their coverage. To evaluate the effectiveness and efficiency of MOIMPA, tests are conducted on various benchmark functions, including ZDT and DTLZ, as well as using the evolutionary computation 2009 (CEC’09) test suite. The algorithm is also evaluated on engineering design problems. A comparison is made between the proposed multi-objective approach and other well-known evolutionary optimization methods, such as MOMPA, multi-objective ant lion optimizer, and multi-objective multi-verse optimization. The statistical results demonstrate the robustness of the MOIMPA approach, as measured by metrics like inverted generational distance, generalized distance, spacing, and delta. Furthermore, qualitative experimental results confirm that MOIMPA provides highly accurate approximations of the true Pareto fronts.
Living with metastatic breast cancer (LIMBER): experiences, quality of life, gaps in information, care and support of patients in the UK
Authors: Fallowfield L. , Starkings R. , Palmieri C. , Tait A. , Stephen L. , May S. , Habibi R. , Russ S. , Shilling V. , Jenkins V. 
Published: July 2023

Abstract
Purpose
To determine the experiences, information, support needs and quality of life of women in the UK living with metastatic breast cancer (MBC) to provide content for educational materials.

Methods
An online survey, hosted for 3 months on a UK MBC charity website, comprised sections covering issues such as communication about MBC treatment and management, helpful and less helpful things that healthcare professionals, family and friends did or said and completion of the Patient Roles and Responsibilities Scale (PRRS).

Results
A total of 143 patients participated; 48/143(33%) presented de novo; 54/143(38%) had been living with MBC > 2 years. PRRS analysis revealed that MBC imposed a serious impact upon most respondents’ own caring abilities and social lives. A majority 98/139 (71%) wished they had known more about MBC before their diagnosis; 63/134(47%) indicated that they still did not fully understand their illness; merely 78/139(56%) had access to a specialist nurse and only 69/135(51%) had been offered any additional support. Respondents reported little consideration given to their lifestyle/culture during consultations and inconsistent information, support services, continuity of care or access to clinical trials. They commented upon things health care professionals/friends and family did or said that were useful and cited other behaviours that were especially unhelpful.

Conclusions
MBC exerted a deleterious impact upon patients’ activities of daily living which were exacerbated in part by significant gaps in support, communication and information.

Implications for cancer survivors
LIMBER results are informing the content of educational materials currently being developed for patients’ formal and informal carers.
Dual FGFR and VEGFR inhibition synergistically restrain hexokinase 2-dependent lymphangiogenesis and immune escape in intrahepatic cholangiocarcinoma
Authors: Peng Min , Li Hui , Cao Huan , Huang Yamei , Yu Weiping , Shen Chuanlai , Gu Jinyang 
Published: July 2023

AbstractBackgroundTherapies for cholangiocarcinoma are largely limited and ineffective. Herein, we examined the role of the FGF and VEGF pathways in regulating lymphangiogenesis and PD-L1 expression in intrahepatic cholangiocarcinoma (iCCA).MethodsThe lymphangiogenic functions of FGF and VEGF were evaluated in lymphatic endothelial cells (LECs) and iCCA xenograft mouse models. The relationship between VEGF and hexokinase 2 (HK2) was validated in LECs by western blot, immunofluorescence, ChIP and luciferase reporter assays. The efficacy of the combination therapy was assessed in LECs and xenograft models. Microarray analysis was used to evaluate the pathological relationships of FGFR1 and VEGFR3 with HK2 in human lymphatic vessels.ResultsFGF promoted lymphangiogenesis through c-MYC-dependent modulation of HK2 expression. VEGFC also upregulated HK2 expression. Mechanistically, VEGFC phosphorylated components of the PI3K/Akt/mTOR axis to upregulate HIF-1α expression at the translational level, and HIF-1α then bound to the HK2 promoter region to activate its transcription. More importantly, dual FGFR and VEGFR inhibition with infigratinib and SAR131675 almost completely inhibited lymphangiogenesis, and significantly suppressed iCCA tumor growth and progression by reducing PD-L1 expression in LECs.ConclusionsDual FGFR and VEGFR inhibition inhibits lymphangiogenesis through suppression of c-MYC-dependent and HIF-1α-mediated HK2 expression, respectively. HK2 downregulation decreased glycolytic activity and further attenuated PD-L1 expression. Our findings suggest that dual FGFR and VEGFR blockade is an effective novel combination strategy to inhibit lymphangiogenesis and improve immunocompetence in iCCA.