bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influence of Sex on Early Axial Spondyloarthritis: ASix‐YearLongitudinal Analysis From a Large National Cohort
Authors: Aouad Krystel , Tournadre Anne , Lucasson Florian , Wendling Daniel , Molto Anna , Fautrel Bruno , Gossec Laure 
Published: February 2023

ObjectiveThe objective was to determine sex differences in disease outcomes in recent axial spondyloarthritis (SpA) over time.MethodsWe analyzed the first 6 years of follow‐up of the prospective French multicenter DESIR cohort. Patients analyzed had <3 years of disease, were naive to disease‐modifying antirheumatic drugs, and fulfilled the Assessment of SpondyloArthritis international Society classification criteria for axial SpA. Disease activity (Ankylosing Spondylitis Disease Activity Score [ASDAS] using the C‐reactive protein [CRP] level), patient global assessment (PtGA), CRP level, and radiographic sacroiliitis were compared between men and women (self‐reported sex) by linear and logistic mixed‐effects models. Models were created for trajectories of disease activity over 6 years in men and women, using k‐means.ResultsOf 494 patients analyzed (mean ± SD age 31.9 ± 7.5 years, symptoms duration 20.7 ± 11.7 months), 50.4% were men. Over 6 years of follow‐up, both men and women showed clear improvements in ASDAS‐CRP, PtGA, and CRP level. Women had higher ASDAS‐CRP and PtGA over time compared to men (bothP < 0.0001) with overall similar CRP levels (P = 0.089), whereas structural damage increased more in men (P < 0.0001). One‐third of both men (33%) and women (34%) belonged to persistent high/very high disease activity trajectories, but ASDAS‐CRP was globally higher in women in these trajectories.ConclusionIn early axial SpA, clinical outcomes (disease activity and symptoms) were worse in women than men over 6 years of follow‐up, whereas CRP was similar and structural damage was more frequent in men. Although similarly distributed, disease activity scores were higher in women in high/very high disease activity trajectories. Sex appears to be an important contextual factor in axial SpA.image
Socioeconomic, Disease‐Related, and Personal Factors Associated With Participation in Remote Follow‐Up in Rheumatoid Arthritis: A Cross‐Sectional Study
Authors: Schougaard Liv M. V. , Knudsen Line R. , Grove Birgith E. , Vestergaard Jesper M. , Hjollund Niels H. , Hauge Ellen‐Margrethe , de Thurah Annette 
Published: February 2023

ObjectiveTo identify socioeconomic, disease‐related, and personal factors associated with participation in remote follow‐up in patients with rheumatoid arthritis (RA).MethodsFollowing the implementation of a patient‐reported outcome‐based remote follow‐up intervention in RA patients in Denmark, a cross‐sectional study was conducted among 775 prevalent patients. In 2019, an electronic questionnaire was sent to eligible RA patients, covering health literacy and patient experience regarding involvement and confidence with remote care. Questionnaire data were linked to nationwide registries regarding socioeconomic status, labor market affiliation, and comorbidity level. Associations between registry‐ and questionnaire‐based factors and remote follow‐up were analyzed using multiple logistic regression analysis.ResultsAll 775 patients were included in the registry‐based analyses, but only 394 of 646 (61%) completed the questionnaire. No attachment to the labor market or low household income was associated with lower odds of remote follow‐up participation (odds ratio [OR] 0.53 [95% confidence interval (95% CI) 0.34–0.83]) and (OR 0.69 [95% CI 0.48–1.00]). Further, a high level of comorbidity was associated with lower odds of remote follow‐up participation compared to a low/medium level of comorbidity (OR 0.53 [95% CI 0.34–0.81]). No association was found between health literacy and remote follow‐up, but remote follow‐up attendees reported more confidence in remote care (OR 1.33 [95% CI 1.21–1.47]).ConclusionParticipation in remote follow‐up was associated with attachement to the labor market, household income, degree of comorbidity, and confidence with remote care. Additional research is necessary to investigate whether a larger and more divergent group of RA patients should be considered for inclusion in remote follow‐up programs.
Systemic Lupus Erythematosus May Be a Risk Factor for Antimalarial‐Induced Retinopathy Compared With Other Rheumatologic Diseases
Authors: Liu Hsin Yen , Cramarossa Gemma , Pope Janet E. 
Published: February 2023

ObjectiveTo describe the pattern and risk factors for antimalarial (AM)‐induced retinopathy in patients with rheumatic diseases.MethodsA retrospective chart review was conducted at an urban Canadian center for patients with AM use of more than 3 months and documented retinopathy screening. Univariate and multivariate regression analyses were performed to determine risk factors for retinopathy. Sensitivity analyses included stratification of analysis by method of screening and by hydroxychloroquine (HCQ) versus chloroquine (CQ).ResultsA total of 613 patients were included in the final analysis, with systemic lupus erythematosus (SLE) (n = 259) as the most common diagnosis. Definite AM‐induced retinal toxicity was observed in 12 patients, 11 of whom had SLE. The earliest diagnosis of toxicity occurred after 5.4 years of AM therapy, and the prevalence beyond 5 years was 3.1%. In univariate analysis, a diagnosis of SLE (P = 0.009; odds ratio [OR]: 15.66; 95% confidence interval [CI]: 2.01‐122.05), the daily weight‐based dose of HCQ (P = 0.044; OR: 1.49; 95% CI: 1.01‐2.20), cumulative CQ dose (P = 0.014; OR: 4.80; CI: 1.37‐16.84), and daily CQ weight‐based dose (P = 0.0001; OR: 5.70; 95% CI: 2.41‐13.49) were significantly associated with toxicity. In multivariate analysis, diagnosis of SLE (P = 0.022; OR: 12.14; 95% CI: 1.44‐102.44) and daily CQ weight‐based dose (P = 0.005; OR: 1.83; 95% CI: 1.83‐26.75) were significant after adjusting for standard covariates.ConclusionThe risk of AM‐induced retinopathy increases after 5 years of therapy. There may be higher rates of toxicity in patients with SLE because of longer duration of treatment, higher weight‐based dosages, and more CQ use in this population, and SLE may be an independent risk factor.
Periodical Ripening for MOCVD Growth of Large 2D Transition Metal Dichalcogenide Domains
Authors: Liu Mengjie , Liao Jing , Liu Yu , Li Luyang , Wen Rongji , Hou Tianyu , Ji Rui , Wang Kaili , Xing Zhigang , Zheng Dong , Yuan Junyang , Hu Fengrui , Tian Yongtao , Wang Xiaoyong , Zhang Yi , Bachmatiuk Alicja , Rümmeli Mark Hermann , Zuo Ran , Hao Yufeng 
Published: February 2023

Abstract2D semiconductors, especially 2D transition metal dichalcogenides (TMDCs), have attracted ever‐growing attention toward extending Moore's law beyond silicon. Metal–organic chemical vapor deposition (MOCVD) has been widely considered as a scalable technique to achieve wafer‐scale TMDC films for applications. However, current MOCVD process usually suffers from small domain size with only hundreds of nanometers, in which dense grain boundary defects degrade the crystalline quality of the films. Here, a periodical varying‐temperature ripening (PVTR) process is demonstrated to grow wafer‐scale high crystalline TMDC films by MOCVD. It is found that the high‐temperature ripening significantly reduces the nucleation density and therefore enables single‐crystal domain size over 20 µm. In this process, no additives or etchants are involved, which facilitates low impurity concentration in the grown films. Atom‐resolved electron microscopy imaging, variable temperature photoluminescence (PL) spectroscopy, and electrical transport results further confirm comparable crystalline quality to those observed in mechanically exfoliated TMDC films. The research provides a scalable route to produce high‐quality 2D semiconducting films for applications in electronics and optoelectronics.
Modulation of Alkyl Chain Length on the Thiazole Side Group Enables Over 17% Efficiency in All‐Small‐Molecule Organic Solar Cells
Authors: Ma Kangqiao , Feng Wanying , Liang Huazhe , Chen Hongbin , Wang Yuxin , Wan Xiangjian , Yao Zhaoyang , Li Chenxi , Kan Bin , Chen Yongsheng 
Published: February 2023

AbstractMolecular innovation is highly desirable to achieve efficient all‐small‐molecule organic solar cells (SM‐OSCs). Herein, three small‐molecule donors (SMDs) with alkylated thiazole side groups (namely BO‐1, HD‐1, and OD‐1), which differ only in the alkyl side chain are reported. Although these SMDs possess similar absorption profiles and molecular energy levels, their crystallinity and miscibility with BTP‐eC9 slightly decrease along with the elongation of the alkyl side chain. After blending with BTP‐eC9, different miscibility leads to different degrees of phase separation. Among these SM‐OSCs, the HD‐1‐based device shows a decent bulk‐heterojunction (BHJ) morphology with proper phase separation and more dynamic carrier behavior. Thus, compared to the BO‐1 and OD‐1‐based devices, the HD‐1‐based device achieves a higher short‐circuit current of 26.04 mA cm−2 and a fill factor of 78.46%, leading to an outstanding PCE of 17.19%, which is one of the highest values among SM‐OSCs. This work provides a rational design strategy of SMDs for highly efficient SM‐OSCs.
Hierarchically Injectable Hydrogel Sequentially Delivers AntagomiR‐467a‐3p‐Loaded and AntagomiR‐874‐5p‐Loaded Satellite‐Cell‐Targeting Bioengineered Extracellular Vesicles Attenuating Sarcopenia
Authors: Dai Hanhao , Luo Jun , Deng Lili , Song Chao , Deng Zhibo , Wu Yijing , Gu Song , Xu Jie 
Published: February 2023

AbstractSarcopenia is a geriatric disease characterized by reduced muscle function and mass. The capacity to self‐renew and myogenesis of satellite cells (SCs) declines with age, resulting in age‐related sarcopenia. MicroRNAs (miRNAs) can regulate the proliferation and myogenesis of SCs. In this study, it is identified that miR‐467a‐3p and miR‐874‐5p could respectively mediate the stemness and myogenesis of SCs by performing bioinformatics analysis. AntagomiR‐467a‐3p (ant‐467a) and antagomiR‐874‐5p (ant‐874) improve the stemness and myogenesis of SCs, respectively. SC‐targeting extracellular vesicles (EVs) are constructed by overexpressing TSG101 on the surface of EVs isolated from bone marrow mesenchymal stem cells. Ant‐467a loaded EVs (EVs‐467a) and ant‐874 loaded EVs (EVs‐874) are prepared by transferring ant‐467a and ant‐874 into SC‐targeting EVs. EVs‐467a and EVs‐874 are more effective than ant‐467a and ant‐874 in promoting the stemness and myogenesis of SCs. Sequentially intermuscular injection of EVs‐467a and EVs‐874 significantly improve sarcopenia in ovariectomy mice. The effects of multiple injections of EVs‐467a and EVs‐874 in the treatment of sarcopenia could be achieved by using a hierarchically injectable hydrogel to sustainedly release EVs‐467a and EVs‐874 in vivo. The findings provide an EV‐based SC‐targeting antagomiRNAs controlled release strategy as a novel therapy against sarcopenia.
Multivalent Nanobody Conjugate with Rigid, Reactive Oxygen Species Scavenging Scaffold for Multi‐Target Therapy of Alzheimer's Disease
Authors: Zhao Liyuan , Meng Fanling , Li Yingjie , Liu Sujuan , Xu Mengmeng , Chu Fan , Li Chuanzhou , Yang Xiangliang , Luo Liang 
Published: February 2023

AbstractEfficient therapeutic strategies that concurrently target both Aβ aggregation and oxidative stress in the Alzheimer's disease (AD) microenvironment emerge as a cutting‐edge tool to combat the intricate pathogenesis of AD. Here, a multivalent nanobody conjugate with rigid, reactive oxygen species (ROS) scavenging scaffold is developed to achieve simultaneous Aβ amyloidogenesis mitigation, ROS elimination, and Aβ plaque clearance. Grafting Aβ segment (33‐GLMVGGVVIA‐42) into the third complementary‐determining region of a parent nanobody generates an engineered nanobody NB that can recognize Aβ and inhibit its aggregation through homotypic interactions. NB is further genetically modified with a fragment of human interleukin‐1β (163‐VQGEESNDK‐171), so that the obtained fusion nanobody NBIL can also facilitate the Aβ clearance by microglia. Linking NBIL covalently onto a rigid, ROS scavenging scaffold poly(deca‐4,6‐diynedioic acid) (PDDA) creates the multivalent nanobody conjugate PNBIL, which not only boosts the binding affinity between NBIL and Aβ aggregates for nearly 100 times but also possesses a long‐term capability of oxidative stress alleviation, inflammation reduction, and neuron protection. PNBIL has significantly attenuated symptoms on two AD mouse models through amyloidogenesis inhibition and AD microenvironment modulation, validating that the multivalent nanobody conjugate design based on combinatory nanobody and molecular engineering is a promising approach of multi‐target therapeutic strategies.
Realizing Wide‐Gamut Human‐Centric Display Lighting with K3AlP3O9N:Eu2+
Authors: Hariyani Shruti , Xing Xinxin , Amachraa Mahdi , Bao Jiming , Ong Shyue Ping , Brgoch Jakoah 
Published: February 2023

AbstractComputers, televisions, and smartphones are revolutionized by the invention of InGaN blue light‐emitting diode (LED) backlighting. Yet, continual exposure to the intense blue LED emission from these modern displays can cause insomnia and mood disorders. Developing “human‐centric” backlighting that uses a violet‐emitting LED chip and a trichromatic phosphor mixture to generate color images is one approach that addresses this problem. The challenge is finding a blue‐emitting phosphor that possesses a sufficiently small Stokes’ shift to efficiently down‐convert violet LED light and produce a narrow blue emission. This work reports a new oxynitride phosphor that meets this demand. K3AlP3O9N:Eu2+ exhibits an unexpectedly narrow (45 nm, 2206 cm−1), thermally robust, and efficient blue photoluminescence upon violet excitation. Computational modeling and temperature‐dependent optical property measurements reveal that the narrow emission arises from a rare combination of preferential excitation and site‐selective quenching. The resulting chromaticity coordinates of K3AlP3O9N:Eu2+ lie closer to the vertex of the Rec. 2020 than a blue LED chip and provides access to ≈10% more colors than a commercial tablet when combined with commercial red‐ and green‐emitting phosphors. Alongside the wide gamut, tuning the emission from the violet LED and phosphor blend can reduce blue light emissions to produce next‐generation, human‐centric displays.
Electric‐Field‐Driven Printed 3D Highly Ordered Microstructure with Cell Feature Size Promotes the Maturation of Engineered Cardiac Tissues
Authors: Zhang Guangming , Li Wenhai , Yu Miao , Huang Hui , Wang Yaning , Han Zhifeng , Shi Kai , Ma Lingxuan , Yu Zhihao , Zhu Xiaoyang , Peng Zilong , Xu Yue , Li Xiaoyun , Hu Shijun , He Jiankang , Li Dichen , Xi Yongming , Lan Hongbo , Xu Lin , Tang Mingliang , Xiao Miao 
Published: February 2023

AbstractEngineered cardiac tissues (ECTs) derived from human induced pluripotent stem cells (hiPSCs) are viable alternatives for cardiac repair, patient‐specific disease modeling, and drug discovery. However, the immature state of ECTs limits their clinical utility. The microenvironment fabricated using 3D scaffolds can affect cell fate, and is crucial for the maturation of ECTs. Herein, the authors demonstrate an electric‐field‐driven (EFD) printed 3D highly ordered microstructure with cell feature size to promote the maturation of ECTs. The simulation and experimental results demonstrate that the EFD jet microscale 3D printing overcomes the jet repulsion without any prior requirements for both conductive and insulating substrates. Furthermore, the 3D highly ordered microstructures with a fiber diameter of 10–20 µm and spacing of 60–80 µm have been fabricated by maintaining a vertical jet, achieving the largest ratio of fiber diameter/spacing of 0.29. The hiPSCs‐derived cardiomyocytes formed ordered ECTs with their sarcomere growth along the fiber and developed synchronous functional ECTs inside the 3D‐printed scaffold with matured calcium handling compared to the 2D coverslip. Therefore, the EFD jet 3D microscale printing process facilitates the fabrication of scaffolds providing a suitable microenvironment to promote the maturation of ECTs, thereby showing great potential for cardiac tissue engineering.
Modulating the Mixing Gibbs Free Energy to Enhance Solid–Liquid Phase Separation for High‐Performance Organic Solar Cells
Authors: He Xinjun , Chan Christopher C. S. , Zou Xinhui , Zhang Sen , Fong Patrick Wai Keung , Kim Jinwook , Li Gang , Hu Xiaotian , Ma Wei , Wong Kam Sing , Choy Wallace C. H. 
Published: February 2023

AbstractOrganic solar cells (OSC) feature a hierarchical structure with the electron donor/acceptor layer sandwiched by anode and cathode, which raises the importance of controlling the molecular crystal orientation, domain size, and vertical distribution to facilitate the charge collection at electrodes. However, the similar conjugated backbone of donor/acceptor material and fast film‐formation kinetics have led to spinodal‐decomposition‐orientated phase separation that result in the film presenting an intimately mixed morphology and random molecular orientation. To solve the issue, the mixing Gibbs free energy‐triggered solid–liquid phase separation during the film formation process is enhanced by solidifying one component and solvating the other based on a liquid additive. Following the liquid evaporation process, a favorable vertical distribution is obtained. Meanwhile, the prolonged solvation process enlarges the domain size and assists the molecules to diffuse and orient properly, enabling better exciton/charge dynamics during the power conversion processes. As a result, the fabricated devices exhibit a fill factor over 80% and an efficiency of 18.72%, which is one of the top efficiencies for binary OSCs. Insights and a methodology is provided here to manipulate the organic donor/acceptor phase separation in terms of mixing Gibbs free energy.
Portrait of autosomal recessive diseases in the French‐Canadian founder population of Saguenay‐Lac‐Saint‐Jean
Authors: Cruz Marino Tania , Leblanc Josianne , Pratte Annabelle , Tardif Jessica , Thomas Marie‐Jacqueline , Fortin Carol‐Ann , Girard Lysanne , Bouchard Luigi 
Published: February 2023

AbstractThe population of the Saguenay‐Lac‐Saint‐Jean (SLSJ) region, located in the province of Quebec, Canada, is recognized as a founder population, where some rare autosomal recessive diseases show a high prevalence. Through the clinical and molecular study of 82 affected individuals from 60 families, this study outlines 12 diseases identified as recurrent in SLSJ. Their carrier frequency was estimated with the contribution of 1059 healthy individuals, increasing the number of autosomal recessive diseases with known carrier frequency in this region from 14 to 25. We review the main clinical and molecular features previously reported for these disorders. Five of the studied diseases have a potential lethal effect and three are associated with intellectual deficiency. Therefore, we believe that the provincial program for carrier screening should be extended to include these eight disorders. The high‐carrier frequency, together with the absence of consanguinity in most of these unrelated families, suggest a founder effect and genetic drift for the 12 recurrent variants. We recommend further studies to validate this hypothesis, as well as to extend the present study to other regions in the province of Quebec, since some of these disorders could also be present in other French‐Canadian families.
Zweiwertige Lanthanoid‐Tetraisobutylaluminate: Reaktivität und lebende Isoprenpolymerisation
Authors: Moinet Eric C. , Wolf Benjamin M. , Tardif Olivier , Maichle‐Mössmer Cäcilia , Anwander Reiner 
Published: February 2023

AbstractLanthanoid (Ln)‐Tetraisobutylaluminate sind Schlüsselkomponenten in kommerziell genutzten Katalysatoren für die 1,3‐Dienpolymerisation und sind gleichsam Seltenerdmetall‐Katalysatoren von wesentlicher industrieller Relevanz. Die hier beschriebenen, diskreten zweiwertigen Seltenerdmetall‐Komplexe [Ln(AliBu4)2] (Ln=Sm, Eu, Yb) sind die ersten strukturell charakterisierten, homoleptischen Tetraisobutylaluminat‐Komplexe. Durch Umsetzen von [Ln(AliBu4)2] mit C2Cl6 wird der gemischtvalente SmII/SmIII‐Cluster [Sm6Cl8(AliBu4)6], sowie der YbII‐Cluster [Yb4Cl4(AliBu4)4] erhalten. Reaktion mit B(C6F5)3 führt zur Hydridabstraktion und zur Bildung Aren‐koordinierter Hydridoborate, wie beispielsweise [Sm{HB(C6F5)3}2(Toluol)2]. Die Komplexe [Ln(AliBu4)2] sind Einkomponentenkatalysatoren für die cis‐1,4‐selektive Polymerisation von Isopren mit enger Molmassenverteilung. Das Zweikomponentenkatalysatorsystem [Yb(AliBu4)2]/[HNPhMe2][B(C6F5)4] katalysiert die lebende Isoprenpolymerisation, wobei die aktiven, zweiwertigen Spezies mittels NMR‐Spektroskopie untersucht werden.
Designing an Apparently Orbital‐Symmetry‐Forbidden [3s,5s]‐Sigmatropic Shift through Transition‐State Complexation and Stereoelectronic Effects
Authors: Ahmed Yusef G. , Tantillo Dean J. 
Published: February 2023

AbstractThe [3s,5s]‐sigmatropic shift is an example of an orbital‐symmetry forbidden pericyclic reaction that is outcompeted by the allowed [3s,3s]‐sigmatropic shift. Density functional theory calculations are used to show that PdII‐complexed systems with strategically placed substituents engaging in key stereoelectronic effects can select for the [3s,5s] process, thereby outcompeting both orbital‐symmetry‐allowed [3s,3s]‐ and [3s,5a]‐shifts.
A Spiro Phosphamide Catalyzed Enantioselective Proton Transfer of Ylides in a Free Carbene Insertion into N−H Bonds
Authors: Pan Jia‐Bin , Zhang Xuan‐Ge , Shi Yi‐Fan , Han Ai‐Cui , Chen Yu‐Jia , Ouyang Jing , Li Mao‐Lin , Zhou Qi‐Lin 
Published: February 2023

AbstractFree carbene readily causes multiple side reactions due to its high energy, thus its asymmetric transformation is very difficult. We present here our findings of high‐pKa Brønsted acid catalysts that enable free carbene insertion into N−H bonds of amines to prepare chiral α‐amino acid derivatives with high enantioselectivity. Under irradiation with visible light, diazo compounds produce high‐energy free carbenes that are captured by amines to form free ylide intermediates, and then the newly designed high‐pKa Brønsted acids, chiral spiro phosphamides, promote the proton transfer of ylides to afford the products. Computational and kinetic studies uncover the principle for the rational design of proton‐transfer catalysts and explain how the catalysts accelerate this transformation and provide stereocontrol.
Augmenting the Performance of Hydrogenase for Aerobic Photocatalytic Hydrogen Evolution via Solvent Tuning
Authors: Allan Michael G. , Pichon Thomas , McCune Jade A. , Cavazza Christine , Le Goff Alan , Kühnel Moritz F. 
Published: February 2023

AbstractThis work showcases the performance of [NiFeSe] hydrogenase from Desulfomicrobium baculatum for solar‐driven hydrogen generation in a variety of organic‐based deep eutectic solvents. Despite its well‐known sensitivity towards air and organic solvents, the hydrogenase shows remarkable performance under an aerobic atmosphere in these solvents when paired with a TiO2 photocatalyst. Tuning the water content further increases hydrogen evolution activity to a TOF of 60±3 s−1 and quantum yield to 2.3±0.4 % under aerobic conditions, compared to a TOF of 4 s−1 in a purely aqueous solvent. Contrary to common belief, this work therefore demonstrates that placing natural hydrogenases into non‐natural environments can enhance their intrinsic activity beyond their natural performance, paving the way for full water splitting using hydrogenases.