bluuebunny/crossref_metadata_2025_split huggingface dataset:
Circadian typologies and insomnia in individuals with internet gaming disorder comorbid with attention deficit/hyperactivity disorder
Authors: Lin Yen Ju , Yen Ju-Yu , Lin Pai-Cheng , Liao Hui-Yuan , Ko Chih-Hung 
Published: August 2023

AbstractThe alteration in circadian typology and insomnia were prevalent among both Individuals with IGD and those with attention deficit hyperactivity disorder (ADHD), the most comorbid psychiatric disorder of IGD. This study aimed to evaluate the relationships between circadian typologies, insomnia, and internet gaming disorder (IGD) and how ADHD affects this relationship. We recruited three groups of 69 young adults: an IGD group, a control group comprising age- and sex-matched nongamers, and a group of gamers without IGD through diagnostic interviews. The participants with IGD exhibited lower composite scale of morningness (CSM) scores and thus a higher eveningness preference In addition, the score of Pittsburgh insomnia rating scale—20-item version (PIRS_20) was significantly higher among those with IGD. The participants with IGD and ADHD exhibited lower CSM scores but higher PRIS_20 scores than the participants with IGD but without ADHD. The present findings indicate that participants with IGD exhibited a tendency of eveningness preference and experienced more severe insomnia. ADHD exacerbated the eveningness preference and insomnia of individuals with IGD. Close attention should be paid to sleep problems in individuals with IGD, particularly to those with ADHD.
Development of sex-linked markers for gender identification of Actinidia arguta
Authors: Guo Dandan , Wang Ran , Fang Jinbao , Zhong Yunpeng , Qi Xiujuan 
Published: August 2023

AbstractThe fruit of the dioecious plant Actinidia arguta has become a great attraction recently. It has long been difficult to distinguish the genders of hybrid seedlings before flowering, therefore increasing the expenditures of breeding. To produce reliable molecular marker for gender identification, this research utilized whole-genome re-sequencing of 15 males and 15 females from an 8-year-old cross population to develop gender specific markers. P51 and P11 were identified as sex-linked markers after verification. Both of these markers, according to the PCR results, only amplified a single band in male samples. These two markers were tested in 97 hybrids (52 females and 45 males) and 31 wild individuals (13 females and 18 males), with an accuracy of 96.88% and 96.09%, correspondingly. This research also verified the universalities of the two markers in Actinidia chinensis samples, and it could be inferred from the PCR results that neither marker was applicable to A. chinensis samples. The BLAST results of the two markers demonstrated that the two markers were closely aligned with different parts of the Y male-specific region of A. chinensis genome, thus they were likely to be useful for the research on the mechanism of sex determination of A. arguta. The two male-linked makers, P51 and P11, have already been used in sex-identification of A. arguta seedlings.
Momordicae Semen inhibits migration and induces apoptotic cell death by regulating c-Myc and CNOT2 in human pancreatic cancer cells
Authors: Jee Wona , Ko Hyun Min , Park Do-Il , Park Ye-Rin , Park So-Mi , Kim Hyungsuk , Na Yun-Cheol , Jung Ji Hoon , Jang Hyeung-Jin 
Published: August 2023

AbstractPancreatic cancer(PC) is less common than other cancers; however, it has a poor prognosis. Therefore, studying novel target signaling and anticancer agents is necessary. Momordicae Semen (MS), the seed of Momordica sochinensis Spreng, mainly found in South-East Asia, including China and Bangladesh, is used to treat various diseases because of its anticancer, antioxidant, anti-inflammatory, and antibacterial properties. However, the effect of the MS extract on pancreatic cancer cells remains unknown. In this study investigated whether the MS extract exerted an anti-cancer effect by regulating c-Myc through CNOT2. Cytotoxicity and proliferation were investigated using MTT and colony formation assays. The levels of apoptotic, oncogenic, and migration-associated factors were confirmed using immunoblotting and immunofluorescence. Wound closure was analyzed using a wound healing assay. The chemical composition of the MS methanol extracts was analyzed using liquid chromatography–mass spectrometry. We confirmed that the MS extract regulated apoptotic factors and attenuated the stability of c-Myc and its sensitivity to fetal bovine serum. Furthermore, the MS extract increased apoptosis by regulating c-Myc and CNOT2 expression and enhanced the sensitivity of 5-FU in pancreatic cancer. This study showed that the MS extract is a promising new drug for PC.
A fluorometric assay to determine labile copper(II) ions in serum
Authors: Maares Maria , Haupt Alessia , Schüßler Christoph , Kulike-Koczula Marcel , Hackler Julian , Keil Claudia , Mohr Isabelle , Schomburg Lutz , Süssmuth Roderich D. , Zischka Hans , Merle Uta , Haase Hajo 
Published: August 2023

AbstractLabile copper(II) ions (Cu2+) in serum are considered to be readily available for cellular uptake and to constitute the biologically active Cu2+ species in the blood. It might also be suitable to reflect copper dyshomeostasis during diseases such as Wilson’s disease (WD) or neurological disorders. So far, no direct quantification method has been described to determine this small Cu2+ subset. This study introduces a fluorometric high throughput assay using the novel Cu2+ binding fluoresceine-peptide sensor FP4 (Kd of the Cu2+-FP4-complex 0.38 pM) to determine labile Cu2+ in human and rat serum. Using 96 human serum samples, labile Cu2+was measured to be 0.14 ± 0.05 pM, showing no correlation with age or other serum trace elements. No sex-specific differences in labile Cu2+ concentrations were noted, in contrast to the total copper levels in serum. Analysis of the effect of drug therapy on labile Cu2+ in the sera of 19 patients with WD showed a significant decrease in labile Cu2+ following copper chelation therapy, suggesting that labile Cu2+ may be a specific marker of disease status and that the assay could be suitable for monitoring treatment progress.
RETRACTED ARTICLE: Energy efficient IRS assisted 6G network for Industry 5.0
Authors: Taneja Ashu , Rani Shalli , Raza Saleem , Jain Amar , Sefat Shebnam M. 
Published: August 2023

AbstractThe real world applications are more prone to difficulties of challenges due to fast growth of technologies and inclusion of artificial intelligence (AI) based logical solutions. The massive internet-of-things (IoT) devices are involved in number of Industry 5.0 applications like smart healthcare, smart manufacturing, smart agriculture, smart transportation. Advanced wireless techniques, customization of services and different technologies are experiencing a major transformation. The desire to increase the communication reliability without adding energy overhead is the major challenge for massive IoT enabled networks. To cope up with the above challenges, Industry 5.0 requirements needs to be monitored at the remote level which again adds on the communication challenge. Use of relays in 6G based wireless networks is denied due to high requirement of energy. Therefore in this paper, Intelligent reflecting surfaces (IRSs) assisted energy constrained 6G wireless networks are studied. To provide seamless connection between the communicating mobile nodes, IRS with an array of reflecting elements are configured in the system set up. A use-case scenario of IRS enabled network in Internet-of-Underwater things (IoUT) for smart ocean transportation is also provided. The IRS assisted wireless network is evaluated for target rates achieved. A power consumption model of the IRS supported system is also proposed to optimise the energy efficiency of the system. Further, the paper evaluates the impact of number of reflecting elements N on the IRS and the phase resolution b of each element on the system performance. The energy efficiency improves by 20% for IRS with $$N=100$$

N
=
100

with $$b=2$$

b
=
2

over IRS with $$b=1$$

b
=
1

.
Object-level complete coverage path planning for excavators in earthwork construction
Authors: Yao Ming , Feng Xianying , Li Peigang , Li Yanfei , Peng Zhiying , Lu Ziteng 
Published: August 2023

AbstractAutonomous excavators are gradually gaining attention because they can reduce the waste of human resources and improve the efficiency. This study proposed a complete coverage path planning algorithm for autonomous excavators based on the Rotating Calipers Path Planning (RCPP) algorithm, which called the Excavator-Rotating Calipers Path Planning (E-RCPP) algorithm. This study uses boustrophedon cellular decomposition (BCD) to decompose the construction area to obtain the convex and non-convex sub-areas without obstacles, and describes a non-decomposition principle to determine whether to decompose non-convex areas that are difficult to plan. To obtain the optimal path, an adaptive spacing adjustment model which is used to adjust the spacing between parallel paths is designed. To improve the coverage rate at the corner, this study proposed a novel boundary corner turning method. The algorithm's cost function considers the path length, the number of turns, the coverage rate and the overlap rate. The Digital Orthophoto Map (DOM) of the construction area is created by Unmanned Aerial Vehicle (UAV) and cropped into three polygonal areas, the 2D top-views of the them are used for simulation experiments to verify the performance of E-RCPP algorithm, the results show that the E-RCPP algorithm has better performance when applied to the complete coverage path planning for excavator compared with the traditional RCPP algorithm.
Synthesis of highly fluorescent carbon quantum dots from rubber seed shells for the adsorption and photocatalytic degradation of dyes
Authors: Nizam Nurul Umairah M. , Hanafiah Marlia M. , Mahmoudi Ebrahim , Mohammad Abdul Wahab 
Published: August 2023

AbstractThe potentials of biomass-based carbon quantum dot (CQD) as an adsorbent for batch adsorption of dyes and its photocatalytic degradation capacity for dyes which are congo red (CR) and methylene blue (MB) have been conducted in this study. The CQDs properties, performance, behaviour, and photoluminescence characteristics were assessed using batch adsorption experiments which were carried out under operating conditions including, temperature, pH and dosage. The morphological analysis revealed that CQDs are highly porous, uniform, closely aligned and multi-layered. The presence of hydroxyl, carboxyl and carbonyl functional groups indicated the significance of the oxygenated functional groups. Spectral analysis of photoluminescence for CQDs confirmed their photoluminescent quality by exhibiting high excitation intensity and possessing greenish-blue fluorescence under UV radiation. The removal percentage of the dyes adsorbed for both CR and MB dyes was 77% and 75%. Langmuir isotherm and pseudo-second-order models closely fitted the adsorption results. Thermodynamics analysis indicated that the adsorption process was exothermic and spontaneous, with excellent reusability and stability. The degradation efficiency of CQDs on both dyes was more than 90% under sunlight irradiation and obeyed the first-order kinetic model. These results demonstrated CQDs to be an excellent adsorbent and outstanding photocatalyst for organic dye degradation.
Maximum Lyapunov exponent-based multiple chaotic slime mold algorithm for real-world optimization
Authors: Yang Jiaru , Zhang Yu , Jin Ting , Lei Zhenyu , Todo Yuki , Gao Shangce 
Published: August 2023

AbstractSlime mold algorithm (SMA) is a nature-inspired algorithm that simulates the biological optimization mechanisms and has achieved great results in various complex stochastic optimization problems. Owing to the simulated biological search principle of slime mold, SMA has a unique advantage in global optimization problem. However, it still suffers from issues of missing the optimal solution or collapsing to local optimum when facing complicated problems. To conquer these drawbacks, we consider adding a novel multi-chaotic local operator to the bio-shock feedback mechanism of SMA to compensate for the lack of exploration of the local solution space with the help of the perturbation nature of the chaotic operator. Based on this, we propose an improved algorithm, namely MCSMA, by investigating how to improve the probabilistic selection of chaotic operators based on the maximum Lyapunov exponent (MLE), an inherent property of chaotic maps. We implement the comparison between MCSMA with other state-of-the-art methods on IEEE Congress on Evolution Computation (CEC) i.e., CEC2017 benchmark test suits and CEC2011 practical problems to demonstrate its potency and perform dendritic neuron model training to test the robustness of MCSMA on classification problems. Finally, the parameters’ sensitivities of MCSMA, the utilization of the solution space, and the effectiveness of the MLE are adequately discussed.
Experimental and spontaneous metastasis assays can result in divergence in clonal architecture
Authors: Serrano Antonin , Weber Tom , Berthelet Jean , El-Saafin Farrah , Gadipally Sreeja , Charafe-Jauffret Emmanuelle , Ginestier Christophe , Mariadason John M. , Oakes Samantha R. , Britt Kara , Naik Shalin H. , Merino Delphine 
Published: August 2023

AbstractIntratumoural heterogeneity is associated with poor outcomes in breast cancer. To understand how malignant clones survive and grow in metastatic niches, in vivo models using cell lines and patient-derived xenografts (PDX) have become the gold standard. Injections of cancer cells in orthotopic sites (spontaneous metastasis assays) or into the vasculature (experimental metastasis assays) have been used interchangeably to study the metastatic cascade from early events or post-intravasation, respectively. However, less is known about how these different routes of injection impact heterogeneity. Herein we directly compared the clonality of spontaneous and experimental metastatic assays using the human cell line MDA-MB-231 and a PDX model. Genetic barcoding was used to study the fitness of the subclones in primary and metastatic sites. Using spontaneous assays, we found that intraductal injections resulted in less diverse tumours compared to other routes of injections. Using experimental metastasis assays via tail vein injection of barcoded MDA-MB-231 cells, we also observed an asymmetry in metastatic heterogeneity between lung and liver that was not observed using spontaneous metastasis assays. These results demonstrate that these assays can result in divergent clonal outputs in terms of metastatic heterogeneity and provide a better understanding of the biases inherent to each technique.
Multi-omic analyses reveal the unique properties of chia (Salvia hispanica) seed metabolism
Authors: Alejo-Jacuinde Gerardo , Nájera-González Héctor-Rogelio , Chávez Montes Ricardo A. , Gutierrez Reyes Cristian D. , Barragán-Rosillo Alfonso Carlos , Perez Sanchez Benjamin , Mechref Yehia , López-Arredondo Damar , Yong-Villalobos Lenin , Herrera-Estrella Luis 
Published: August 2023

AbstractChia (Salvia hispanica) is an emerging crop considered a functional food containing important substances with multiple potential applications. However, the molecular basis of some relevant chia traits, such as seed mucilage and polyphenol content, remains to be discovered. This study generates an improved chromosome-level reference of the chia genome, resolving some highly repetitive regions, describing methylation patterns, and refining genome annotation. Transcriptomic analysis shows that seeds exhibit a unique expression pattern compared to other organs and tissues. Thus, a metabolic and proteomic approach is implemented to study seed composition and seed-produced mucilage. The chia genome exhibits a significant expansion in mucilage synthesis genes (compared to Arabidopsis), and gene network analysis reveals potential regulators controlling seed mucilage production. Rosmarinic acid, a compound with enormous therapeutic potential, was classified as the most abundant polyphenol in seeds, and candidate genes for its complex pathway are described. Overall, this study provides important insights into the molecular basis for the unique characteristics of chia seeds.
Unambiguous joint detection of spatially separated properties of a single photon in the two arms of an interferometer
Authors: Sahoo Surya Narayan , Chakraborti Sanchari , Kanjilal Som , Behera Saumya Ranjan , Home Dipankar , Matzkin Alex , Sinha Urbasi 
Published: August 2023

AbstractThe quantum superposition principle implies that a particle entering an interferometer evolves by simultaneously taking both arms. If a non-destructive, minimally-disturbing interaction coupling a particle property to a pointer is implemented on each arm while maintaining the path superposition, quantum theory predicts that, for a fixed state measured at the output port, certain particle properties can be associated with only one or the other path. This phenomenon is known as the quantum Cheshire cat effect. Here we report the realization of this prediction through joint observation of the spatial and polarization degrees of freedom of a single photon in the two respective arms of an interferometer. Significant pointer shifts ( ~ 50 microns), corresponding to measured weak values, are observed in each arm. This observation, involving coupling distinct properties of a quantum system in spatially separated regions, opens new possibilities for quantum information protocols and for tests of quantumness for mesoscopic systems.
Chiral and helical states in selective-area epitaxial heterostructure
Authors: Sun Huimin , Huang Yu , He Mengyun , Fu Yu , Zheng Sikang , Zhang Bin , Wang Chen , He Qing Lin 
Published: August 2023

AbstractThe quasi-1D chiral edge states in a quantum anomalous Hall insulator are dissipationless, while the 2D helical surface states in a topological insulator are insensitive to spin-independent scatterings due to the topological protection. Both serve as essential ingredients for topological electronics. Here, we integrate these states into a single device using selective area epitaxy based on the molecular beam epitaxy technique. The chiral edge state comes from the quantum anomalous Hall insulator Cr:(Bi,Sb)2Te3, while the helical surface state comes from the intrinsic topological insulator (Bi,Sb)2Te3 which only interfaces with a partial edge of the former, forming a selective-area heterostructure. At the heterointerface, the chiral state in Cr:(Bi,Sb)2Te3 is allowed to be scattered into (Bi,Sb)2Te3 so that the incoming current will be redistributed according to the coordination between the chirality and helicity. Our device enables the collaboration between chiral and helical states for low-dissipative transport with tunable current dimension.
Harbingers of decades of unnatural disasters
Authors: Otto Friederike E. L. , Raju Emmanuel 
Published: August 2023

AbstractExtreme weather events and their impacts have dominated headlines throughout 2021 and 2022. The emphasis on the weather in reports of the events, often discussed in the context of climate change, has led many to believe that these disasters would not have happened without human-induced warming. However, our compilation of severe weather-related hazards and the most severe related disasters in those two years reveals that ultimately, all the listed disasters resulted from existing vulnerabilities and compounding stresses on social systems. Climate change often made the hazard worse, but much of the damage could have been prevented. We emphasise that the reporting of disasters should routinely address not only the weather-related hazards and humans’ role in changing the odds, but also vulnerability in order to guide disaster risk reduction and avoid risk creation processes.
Climate justice through climate finance? Australia’s approach to climate finance in the Pacific
Authors: Ledger Ellen , Klöck Carola 
Published: August 2023

AbstractPacific Island actors have long called for climate justice in the international climate regime, particularly in the form of financial support. While climate finance can be conceptualised as a mechanism of climate justice, the extent to which climate finance does indeed contribute to climate justice is contested. We explore these contestations by looking at Australia’s development programme in the Pacific between 2010 and 2019, examining both policy documents and climate finance flows. This analysis is conducted through a climate justice lens that we conceptualise as consisting of three dimensions: adequacy, additionality, and predictability; balance between adaptation and mitigation and priority provision of adaptation finance to vulnerable recipients; and donor coordination. Our analysis shows that Australian public climate finance has not acted as a mechanism of climate justice according to our criteria in the period studied, even if does meet some criteria of climate justice. From a justice perspective, Australia has approached climate change inconsistently and at times incoherently across its development program in Pacific Island countries. These results provide important lessons for Australia’s approach going forward, under a new government and a new development policy framework.
China’s recycling potential of large-scale public transport vehicles and its implications
Authors: Xiong Xin , Zeng Xianlai , Zhang Zhengyang , Pell Robert , Matsubae Kazuyo , Hu Zhaoji 
Published: August 2023

AbstractTransport infrastructure allows society to function. Such systems continuously improve through manufacturing transformation and technology upgrading. However, its metabolism mechanism of material degradation and quantities from consumption to obsolescence remains unclear. Here we estimate the recycling potential of typical large-scale public transport vehicles (LPTV) in China, in particular, predicting the end-of-life quantity of railway and aviation equipment between 2000 and 2050. Their total recycling potential has been experiencing rapid growth. The total obsolescence mass in 2020 exceeded 33 million tons, and it is expected to reach another 74 million tons by 2050, roughly twice the amount in 2020. By 2050, waste LPTV in China will contain at least 72 million tons of steel, 838 kilotons of aluminum, 2539 tons of titanium, and 223 tons of neodymium. We also compare waste LPTV to e-waste and end-of-life private vehicles. Interestingly, their growth of generation quantity indicates a distinct industry succession from an industrial ecological perspective.
Sedimentation and its effect on storage capacity in Naghlu reservoir
Authors: Bazarov Dilshod , Ahmadi Mahfouz , Vohidov Oybek , Shodiev Bobur , Raimova Iqboloy 
Published: August 2023

The Naghlu reservoir has been studied to determine the level of siltation and sedimentation characteristics in the reservoir bed. The study was fulfilled in two phases, i.e., field survey and laboratory work for determining the level of siltation and carrying out the grain size analyses of the collected sediment samples at 34 locations representing the whole reservoir area.
The Naghlu Dam is a gravity dam which has been built to generate electricity. The dam was built on the Kabul River. Two main tributaries of the Kabul River, i.e., the Kabul and the Panjshir, feed the reservoir. The catchment area of Kabul and Panjshir tributaries feeding the Naghlu reservoir is around 26,000 km2. The reservoir’s surface area is around 15.5 square kilometers, and the volume is 550 million m3 at the normal operation level; the useful volume of the reservoir is around 380 million m3. Dam provides 100 MW of electricity for the surrounding areas, including Kabul and Jalalabad.