bluuebunny/crossref_metadata_2025_split huggingface dataset:
FeS2 nanosheets–H2O2–NaHCO3 chemiluminescence method for procaine hydrochloride determination
Authors: Golshani Pariya , Iranifam Mortaza , Al Lawati Haider A. J. , Hassanpour‐Khaneghah Mahdiyeh 
Published: February 2023

AbstractFeS2 nanosheets (NSs) were produced and exploited as a new catalyst for a chemiluminescence (CL) reaction. The characterization of FeS2 NSs was performed using spectroscopic methods. In this regard, transmission electron microscopy images showed that FeS2 NSs have a length of ~0.5–1 μm. The direct optical band gap energy of FeS2 NSs was found to be 3.45 eV. Prepared FeS2 NSs were used to catalyze the NaHCO3–H2O2 CL reaction. It was found that procaine hydrochloride (PCH) could reduce the intensity of the FeS2 NSs–NaHCO3–H2O2 CL reaction so, with increasing PCH concentrations, the intensity of light emission decreased. Therefore, a simple and sensitive method was introduced to measure PCH with a linear range expanded from 1.00 × 10−6 to 1.00 × 10−3 mol L−1 and an 8.32 × 10−7 mol L−1 limit of detection. Studies related to the effect of foreign species and reaction mechanisms were performed. The application of the approach was verified by quantifying the PCH in the injection.
Thermally stable Sm3+‐doped alkali zinc alumino borosilicate (AZABS) glass for warm white light generation and w‐LED applications
Authors: Bajaj Rajat , Rohilla Pooja , Prasad Aman , Ravita  , Shandilya Ankur , Rao Allam Srinivasa 
Published: February 2023

AbstractSamarium ion (Sm3+)‐doped alkali zinc alumino borosilicate (AZABS) glass was synthesized via quick melt quench technique. Various spectroscopic studies like optical absorption, photoluminescence (PL) emission, PL excitation, temperature‐dependent PL and PL decay kinetics were performed on the as prepared glass system. Under 402 nm excitation, three sharp bands at wavelengths 563, 599 and 645 nm corresponding to transitions 4G5/2 → 6H5/2, 6H7/2 and 6H9/2, respectively, can be seen in the PL emission spectra. The 0.25 mol% Sm3+ glass has the highest intensity for these emissions. The lanthanide interaction in the glass matrix is dipole–dipole in nature as was proven from Dexter's analysis. The direct bandgap of 0.25 mol% Sm3+‐doped AZABS glass was calculated to be 2.88 eV. The lifetimes of the as prepared glass range from 1.93 ms for the lowest concentration of Sm3+ to 0.75 ms for the highest. From temperature dependent PL studies, the activation energy for 0.25 mol% Sm3+‐doped AZABS glass was found to be 0.19 eV which shows high thermal stability of this glass. We propose to utilize these Sm3+‐doped AZABS glasses for white‐light emitting diodes (w‐LEDs) and solid‐state lighting (SSL) applications.
Electroacupuncture reverses endothelial cell death and promotes angiogenesis through the VEGF/Notch signaling pathway after focal cerebral ischemia‐reperfusion injury
Authors: Zhang Wenyu , Han Lin , Wen Yan , Su Lixian , Li Yibing , Luo Xudong 
Published: February 2023

AbstractBackgroundAngiogenesis is an important mechanism of recovery from ischemic stroke. Recent studies have found that there is a close relationship between the VEGF/Notch pathway and angiogenesis. It is unknown whether EA can exert a brain protection effect and promote angiogenesis by acting on the VEGF/Notch signaling pathway after focal cerebral ischemia‐reperfusion injury (CIRI).MethodsThe Middle Cerebral Artery occlusion/Reperfusion (MCAo/R) model was established, in which rats were subjected to occlusion with ischemic intervention for 30 min, followed by reperfusion for 8 h, 1 day, 3 days, and 7 days. The first EA treatment was performed 90 min after the animal model was successfully established, and then EA treatments were performed once a day for 7 days. The 2,3,5‐triphenyltetrazolium chloride staining and neurological deficit examination were performed to assess the level of CIRI and neuroprotection by EA. Expression levels of VEGFA, Notch1, and Hes1 proteins were measured via western blotting, while the morphological changes of ECs and microvasculature in the cortex were determined using an ultrastructural observation method.ResultsEA treatment of PC6, GV26, and SP6 can significantly improve the neurological function of MCAO/R rats, reduce the volume of cerebral infarction, and modulate the ultrastructure of ECs and microvessels in pathological states. Western blotting revealed that EA increased VEGFA protein expression at 8 h and 3 days after CIRI, as well as Notch1 protein expression at 1 and 7 days. Subsequently, EA activated the VEGF/Notch pathway, increasing the expression of the downstream target protein Hes1, reversing EC death, and promoting angiogenesis.ConclusionOur findings showed that EA plays a role in promoting angiogenesis following focal CIRI, and we hypothesized that this was due to the regulation of ECs by the EA‐activated VEGF/Notch signaling pathway.
ARID3A plays a key regulatory role in palmitic acid‐stimulated milk fat synthesis in mouse mammary epithelial cells
Authors: Guo Xudong , Qi Hao , Lin Gang , Yu Jiaxiao , Zhang Minghui , Gao Xuejun 
Published: February 2023

AbstractPalmitic acid (PA) can stimulate milk fat synthesis in mammary gland, but the specific mechanism is still unclear. In our research, we aim to explore the role and corresponding mechanism of AT‐rich interaction domain 3A (ARID3A) in milk fat synthesis stimulated by PA. We found that ARID3A protein level in mouse mammary gland tissues during lactation was much higher than that during puberty and involution. ARID3A knockdown and gene activation showed that ARID3A stimulated the synthesis of triglycerides and cholesterol in HC11 cells, secretion of free fatty acids from cells and lipid droplet formation in cells. ARID3A also promoted the expression and maturation of SREBP1 in HC11 cells. PA stimulated ARID3A protein expression and SREBP1 expression and maturation in a dose‐dependent manner, and the PI3K specific inhibitor LY294002 blocked the stimulation of PA on ARID3A expression. ARID3A knockdown blocked the stimulation of PA on SREBP1 protein expression and maturation. We further showed that ARID3A was localized in the nucleus and PA stimulated this localization, and ARID3A knockdown blocked the stimulation of PA on the mRNA expression of SREBP1. To sum up, our data reveal that ARID3A is a key mediator for PA to promote SREBP1 mRNA expression and stimulate milk fat synthesis in mammary epithelial cells.
Commentary: Plaque burden estimated from optical coherence tomography with Deep Learning: In‐vivo validation using coregistered intravascular ultrasound
Authors: Alasnag Mirvat 
Published: February 2023

Key Points
Visibility of the media poses a challenge to accurate evaluation of plaque by conventional optical coherence tomography (OCT).
Deep Learning algorithms are reliable for the assessment of plaque burden using OCT.
Larger studies are necessary to validate such algorithms.
Synthesis and Applications of Bicyclo[1.1.0]butyl and Azabicyclo[1.1.0]butyl Organometallics
Authors: Tyler Jasper L. , Aggarwal Varinder K. 
Published: February 2023

AbstractThe use of metalated (aza)bicyclo[1.1.0]butanes in synthesis is currently experiencing a renaissance, as evidenced by the numerous reports in the last 5 years that have relied on such intermediates to undergo unique transformations or generate novel fragments. Since their discovery, these species have been demonstrated to participate in a wide range of reactions with carbon and heteroatom electrophiles, as well as metal complexes, to facilitate the rapid diversification of (aza)bicyclo[1.1.0]butane‐containing compounds. Key to this is the relative acidity of the bridgehead C−H bonds which promotes facile deprotonation and subsequent functionalization of an unsubstituted position on the carbon framework via the intermediacy of a metalated (aza)bicyclo[1.1.0]butane. Additionally, the late‐stage incorporation of deuterium atoms in strained fragments has led to the elucidation of numerous reaction mechanisms that involve strained bicycles. The continued investigation into the inimitable reactivity of metalated bicycles will cement their importance within the field of organometallic chemistry.
Recent Progress in Artificial Structural Colors and their Applications in Fibers and Textiles
Authors: Li Run , Zhang Shiliang , Zhang Rufan 
Published: February 2023

AbstractStructural colors have been regarded as an ideal alternative to pigments because of the advantages of environmental friendliness, resistance to fading, especially in the fields of textile dyeing and printing, which is highly polluted in traditional ways and needs to be upgraded. They are generated by the interaction between the micro/nano structure of the material surface and the incident light, which is closely related to the sizes and periods of the structures. Based on different nano arrangements, the structures can be roughly divided into photonic crystals and non‐photonic crystals. In this review, we summarized recent research progress in structural coloration of fibers and textiles. Learning from nature, researchers proposed various methods to fabricate biomimetic structural colors, and the applications of structural colored fibers and textiles were extended. The challenges and perspectives were also presented. Hopefully, reference for the design and preparation of structural color‐based textiles can be inspired.
Understanding the role of access in Hispanic cancer screening disparities
Authors: Spencer Jennifer C. , Noel Lailea , Shokar Navkiran K. , Pignone Michael P. 
Published: February 2023

AbstractBackgroundHispanic populations in the United States experience numerous barriers to care access. It is unclear how cancer screening disparities between Hispanic and non‐Hispanic White individuals are explained by access to care, including having a usual source of care and health insurance coverage.MethodsA secondary analysis of the 2019 National Health Interview Survey was conducted and included respondents who were sex‐ and age‐eligible for cervical (n = 8316), breast (n = 6025), or colorectal cancer screening (n = 11,313). The proportion of ever screened and up to date for each screening type was compared. Regression models evaluated whether controlling for reporting a usual source of care and type of health insurance (public, private, none) attenuated disparities between Hispanics and non‐Hispanic White individuals.ResultsHispanic individuals were less likely than non‐Hispanic White individuals to be up to date with cervical cancer screening (71.6% vs. 74.6%) and colorectal cancer screening (52.9% vs. 70.3%), but up‐to‐date screening was similar for breast cancer (78.8% vs. 76.3%). Hispanic individuals (vs. non‐Hispanic White) were less likely to have a usual source of care (77.9% vs. 86.0%) and more likely to be uninsured (23.6% vs. 7.1%). In regressions, insurance fully attenuated cervical cancer disparities. Controlling for both usual source of care and insurance type explained approximately half of the colorectal cancer screening disparities (adjusted risk difference: −8.3 [–11.2 to –4.8]).ConclusionAddressing the high rate of uninsurance among Hispanic individuals could mitigate cancer screening disparities. Future research should build on the relative successes of breast cancer screening and investigate additional barriers for colorectal cancer screening.Plain language summary

This study uses data from a national survey to compare cancer screening use those who identify as Hispanic with those who identify as non‐Hispanic White.

Those who identify as Hispanic are much less likely to be up to date with colorectal cancer screening than those who identify as non‐Hispanic White, slightly less likely to be up to date on cervical cancer screening, and similarly likely to receive breast cancer screening.

Improving insurance coverage is important for health equity, as is further exploring what drives higher use of breast cancer screening and lower use of colorectal cancer screening.
Nucleus Independent Chemical Shift (NICS) at Small Distances from the Molecular Plane: The Effect of Electron Density
Authors: Stanger Amnon 
Published: February 2023

AbstractWhen close to the molecular plane, the behavior of nucleus independent chemical shift (NICS) as a function of the distance from the molecular plane deviates from its behavior at larger distances. By using a dense grid of NICS‐probes (BQs) it is shown that, when close to the molecular plane, maximal (absolute) NICS values are obtained above the atoms. These maxima move towards the center as the grid is elevated until the (absolute) maximum NICS is obtained at the center and stay there when the grid is further elevated. It is shown that this behavior is a result of the current density, which is influenced by the electron density, according to the Biot‐Savart law, which, in turn, causes the induced magnetic field measured by the NICS. It is thus concluded that if magnetic aromaticity is studied, the NICS calculations should be carried out at a large enough distance so that only the π‐ring current affects the NICS. At distances ≥2 Å, NICS(r)π,zz=A+B*Cr. Using non‐linear correlation for obtaining A, B and C and extrapolate to NICS(1)π,zz and NICS(1.7)π,zz is recommended as measures for aromaticity.
Gold Triangular Nanoprisms: Anisotropic Plasmonic Materials with Unique Structures and Properties
Authors: Wang Jiangming , Fang Weina , Liu Huajie 
Published: February 2023

AbstractAs a novel type of anisotropic inorganic nanomaterials, gold triangular nanoprisms (AuTNPs) have been widely studied for their well‐defined structures and excellent plasmonic properties. This review starts with synthetic methodology, combing through the early thermal solution method to the mature seed‐mediated method and seedless method. The possible mechanisms proposed by predecessors and the problems needed to be solved are also arranged. Along with this, the important morphological evolution process of AuTNPs during synthesis and post‐synthesis stages are revealed, which is of great significance for further understanding the structure of AuTNPs and developing new synthesis strategies. Finally, the applications of AuTNPs, especially associated with plasmonic properties, are listed and summarized where surface‐enhanced Raman scattering (SERS), catalysis, phototherapy and biosensor are included, so that researchers can quickly comprehend the current situation, and provide a basis for further development and exploration of AuTNPs.
Grip strength, gait speed, and trajectories of cognitive function in community‐dwelling older adults: A prospective study
Authors: Wu Zimu , Woods Robyn L. , Chong Trevor T.‐J. , Orchard Suzanne G. , Shah Raj C. , Wolfe Rory , Storey Elsdon , Sheets Kerry M. , Murray Anne M. , McNeil John J. , Ryan Joanne 
Published: February 2023

AbstractIntroductionThis study investigated whether grip strength and gait speed predict cognitive aging trajectories and examined potential sex‐specific associations.MethodsCommunity‐dwelling older adults (n = 19,114) were followed for up to 7 years, with regular assessment of global function, episodic memory, psychomotor speed, and executive function. Group‐based multi‐trajectory modeling identified joint cognitive trajectories. Multinomial logistic regression examined the association of grip strength and gait speed at baseline with cognitive trajectories.ResultsHigh performers (14.3%, n = 2298) and low performers (4.0%, n = 642) were compared to the average performers (21.8%, n = 3492). Grip strength and gait speed were positively associated with high performance and negatively with low performance (P‐values < 0.01). The association between grip strength and high performance was stronger in women (interaction P < 0.001), while gait speed was a stronger predictor of low performance in men (interaction P < 0.05).DiscussionGrip strength and gait speed are associated with cognitive trajectories in older age, but with sex differences.Highlights
There is inter‐individual variability in late‐life cognitive trajectories.
Grip strength and gait speed predicted cognitive trajectories in older age.
However, sex‐specific associations were identified.
In women, grip strength strongly predicted high, compared to average, trajectory.
In men, gait speed was a stronger predictor of low cognitive performance trajectory.
Use of mechanical circulatory support in patients with non‐ischaemic cardiogenic shock
Authors: Schrage Benedikt , Sundermeyer Jonas , Beer Benedikt Norbert , Bertoldi Letizia , Bernhardt Alexander , Blankenberg Stefan , Dauw Jeroen , Dindane Zouhir , Eckner Dennis , Eitel Ingo , Graf Tobias , Horn Patrick , Kirchhof Paulus , Kluge Stefan , Linke Axel , Landmesser Ulf , Luedike Peter , Lüsebrink Enzo , Mangner Norman , Maniuc Octavian , Winkler Sven Möbius , Nordbeck Peter , Orban Martin , Pappalardo Federico , Pauschinger Matthias , Pazdernik Michal , Proudfoot Alastair , Kelham Matthew , Rassaf Tienush , Reichenspurner Hermann , Scherer Clemens , Schulze Paul Christian , Schwinger Robert H.G. , Skurk Carsten , Sramko Marek , Tavazzi Guido , Thiele Holger , Villanova Luca , Morici Nuccia , Wechsler Antonia , Westenfeld Ralf , Winzer Ephraim , Westermann Dirk 
Published: February 2023

ABSTRACTAimsDespite its high incidence and mortality risk, there is no evidence‐based treatment for non‐ischaemic cardiogenic shock (CS). The aim of this study was to evaluate the use of mechanical circulatory support (MCS) for non‐ischaemic CS treatment.Methods and resultsIn this multicentre, international, retrospective study, data from 890 patients with non‐ischaemic CS, defined as CS due to severe de‐novo or acute‐on‐chronic heart failure with no need for urgent revascularization, treated with or without active MCS, were collected. The association between active MCS use and the primary endpoint of 30‐day mortality was assessed in a 1:1 propensity‐matched cohort. MCS was used in 386 (43%) patients. Patients treated with MCS presented with more severe CS (37% vs. 23% deteriorating CS, 30% vs. 25% in extremis CS) and had a lower left ventricular ejection fraction at baseline (21% vs. 25%). After matching, 267 patients treated with MCS were compared with 267 patients treated without MCS. In the matched cohort, MCS use was associated with a lower 30‐day mortality (hazard ratio 0.76, 95% confidence interval 0.59–0.97). This finding was consistent through all tested subgroups except when CS severity was considered, indicating risk reduction especially in patients with deteriorating CS. However, complications occurred more frequently in patients with MCS; e.g. severe bleeding (16.5% vs. 6.4%) and access‐site related ischaemia (6.7% vs. 0%).ConclusionIn patients with non‐ischaemic CS, MCS use was associated with lower 30‐day mortality as compared to medical therapy only, but also with more complications. Randomized trials are needed to validate these findings.
Oxo‐Bridged Zr Dimers as Well‐defined Models of Oxygen Vacancies on ZrO2
Authors: Wimmer Erik J. , Klostermann Sina V. , Ringenberg Mark , Kästner Johannes , Estes Deven P. 
Published: February 2023

AbstractWhile ZrO2 is known to have a large effect on the activity and selectivity of the Cu/ZrO2 catalyst for methanol synthesis, its role in this process is poorly understood. Surface defects such as oxygen vacancies could play a role in the strong metal‐support interaction (SMSI) between Cu and ZrO2. However, due to the complexity of the surfaces, the exact molecular nature of this interaction is not at present known. Here, we make well‐defined models of both reduced and coordinatively unsaturated surface oxygen vacancies on ZrO2 using the molecular precursor [Cp2ZrCl]2(μ2‐O) (1). Complex 1 can be reduced to form a complex (2) containing one Zr(III) center and a bridging hydride ligand (according to EPR and IR spectroscopy) derived from C−H activation of either thf or the Cp ring. Complex 2 reacts with CO2 to largely produce CO, suggesting that surface defects with similar structures probably do not play a role in the industrial catalyst. Halide abstraction from complex 1 results in the Lewis acidic species 3, which has similar Lewis acid properties to acidic defects on the ZrO2 surface. Similarities of both of these model species to real surface oxygen vacancies and their role in the catalytic reaction are discussed.
Heterometallic Uranyl (Hydroxyethyl)iminodiacetic Acid (Heidi) Complexes: Molecular Models for U(VI) Uptake in Complex Media
Authors: Jahinge Tiron H. L. , Unruh Daniel K. , Forbes Tori Z. 
Published: February 2023

AbstractAmidoximated absorbents (AO‐PAN) effectively remove U(VI) from aqueous solution, but previous studies reported more variability for complex natural waters that contain additional confounding ions and molecules. Ternary phases containing U(VI), M(III) (M=Fe(III), Al(III), Ga(III)), and organic molecules exist under these conditions and cause heterogeneous U(VI) uptake on AO‐PAN. The goal of the current study is to provide additional insights into the structural features ternary complexes using N‐(2‐hydroxyethyl)‐iminodiacetic acid (HEIDI) as the model organic chelator and explore the relevance of these species on U(VI) capture. Three model compounds ([(UO2)(Fe)2(μ3‐O)(C6NO5H8)2(H2O)4] (UFe2), ([(UO2)(Al)2(μ2‐OH)(C6NO5H8)2(H2O)3] (UAl2) and [(UO2)(Ga)2(μ2‐OH)(C6NO5H8)2(H2O)3] (UGa2)) were characterized by single‐crystal X‐ray diffraction. Raman spectra of the model compounds were compared with solution data and the ternary phases were noted in the case of Al(III) and Ga(III), but not in the Fe(III) system. U(VI) adsorption onto AO‐PAN was not impacted by the presence of HEIDI or the trivalent metal species.
Highly Chemoselective One‐Step Synthesis of Novel N‐Substituted‐Pyrrolo[3,4‐b]quinoline‐1,3‐diones via Palladium‐Catalyzed Aminocarbonylation/Carbonylative Cyclisation Sequence
Authors: Chniti Sami , Kollár László , Bényei Attila , Dörnyei Ágnes , Takács Attila 
Published: February 2023

AbstractNovel N‐substituted pyrrolo[3,4‐b]quinoline‐1,3‐diones have been prepared via a highly chemoselective palladium‐catalyzed carbonylative imidazation‐cyclization reaction in a one‐pot synthetic approach. This methodology, which has been applied for the first time to access such original scaffolds through two different protocols involving 3‐bromo‐2‐iodoquinoline, as a typical partner, primary amines, and atmospheric or high carbon monoxide pressure (20 bar), has shown an excellent tolerance for many functional groups. The use of bidentate ligands such as XantPhos and dppp, either under atmospheric or high‐pressure conditions, provides a wide range of carbonylated compounds in good to excellent yields (up to 82 %). Furthermore, some new quinoline‐2,3‐dicarboxamides have been isolated as side products in very low yields and have been fully characterized. The solid state structures of three of the synthesized acridinimides have been unequivocally established by single‐crystal XRD analysis.