bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of the Effects of Quince Seed Mucilage and Wheat Germ Oil on Wound Healing in Rats
Authors: ÇULHA Canan , GÜN Zeynep Ülkü , SELÇUK Aysu , APİKOĞLU-RABUŞ Şule 
Published: September 2023

Objective: People have used traditional herbal medicines for wound care since the dawn of time. This study aimed to assess the cutaneous wound healing effects of wheat germ oil (WGO) and quince seed mucilage (QSM) in rats.
Methods: Adult female Wistar albino rats were allocated to one of the three groups: rats treated with topical WGO (n=6); topical QSM (n=6); and topical saline (n=6) as the control group. Two circular, full-thickness wounds of 0.6 mm diameter were created on the dorsal thoracic region of each rat. Test and control solutions were applied twice daily for 14 days. Wound healing was assessed by measuring the wound contraction rate and the time needed for complete epithelialization.
Results: When compared with the control group, rats in the WGO group had reduced wound closure rates in the first four days, but considerably greater rates in the 8th, 10th, and 12th days, as well as a shorter duration of time needed to complete epithelialization (11 days vs. 13 days). The wound closure rates of the rats in the QSM group were not substantially different from the control rats and the duration of time needed for complete epithelialization was not significantly different from the control group.
Conclusion: WGO use has been shown to improve wound healing. It may be used as an alternative or complementary approach for wound treatment depending on the severity of the wounds. On the other hand, QSM was not found to improve wound healing.
The Effect of Post-Operative Sexual Counseling Carried out with PLISSIT Model on Sexual Function and Sexual Satisfaction in Gynecologic Cancers
Authors: BİLGE Çiğdem , ASLAN Ergül 
Published: September 2023

Objective: This study aims to determine the effect of sexual counseling on the sexual functions and sexual satisfaction of women who underwent surgical treatment due to gynecologic cancer.
Methods: The study sample consisted of 60 women (experimental group n = 30, control group n = 30) with ovarian, endometrial, and cervical cancer. The women in the experimental group received sexual counseling according to PLISSIT, while the women in the control group were not given sexual counseling but were monitored through routine follow-up. The Female Sexual Function Index (FSFI) and the Sexual Satisfaction Scale for Women (SSS-W) were used for the first and last evaluations of the groups.
Results: The mean age of the women in the experimental group was 51.87 ± 8.89, while it was 50.47 ± 9.43 in the control group. There was no significant difference between the two groups in terms of sexual function and sexual satisfaction levels in the first evaluation (p>.05), whereas there was a significant difference between the two groups in the final evaluation after the sexual counseling provided to the experimental group (p < .001). When the first and final evaluations of the women were considered, it was observed that 33.3% of the women in the experimental group had adequate sexual functioning in the final evaluation.
Conclusion: The sexual counseling carried out using the PLISSIT model for women who were treated for gynecologic cancer positively affected their sexual function and sexual satisfaction levels.
STRATEGI PENGEMBANGAN USAHA TANI BUDIDAYA KOPI LIBERIKA, PEMASARAN/PRODUKSI KOPI LIBERIKA DI DESA ANDUNGBIRU, TIRIS, PROBOLINGGO
Authors: Umi Kulsum  
Published: September 2023

Produksi kopi liberika di daerah Andungbiru-Tiris-problinggop mengalami peningkatan sebesar 10 persen ditahun 2022, Hal ini mengindikasikan bahwa perkebunan kopi liberika di daerah ini menjadi bagian komoditas perkebunan potensial dikembangkan dan ditingkatkan. Hal ini diperlukan dengan adanya strategi yang efektif dan efisien agar perkebunan kopi liberika dapat bermanfaat untuk kesejahteraan perekonomian petani. Tujuan penelitian untuk mengukur dan mengetahui potensi kopi liberika sebagai produk potensial didesa Andungbiru, mampu menganalisis dan mengevaluasi faktor internal dan eksternal serta melihat perkembangan jaringan pemasaran dan produksi usaha budidaya tanaman kopi liberika. Penelitian dilakukan dengan menggunakan metode survei. Sampel yang dipilih sebanyak 36 orang. Hasil penelitian menujukkan bahwa sebagian besar petani memilih jenis komoditi kopi liberika, berdasarkan dengan indikator paling tinggi hasil produksi Desa Andungbiru adalah dusun sumber kapung dengan nilai LQ sebanyak 3,20, yaitu setiap satu produksi kopi liberika digunakan untuk kebutuhan daerah sendiri, dan sisanya sebesar 2,10 untuk kebutuhan petani kopi liberika diluar daerah. Hasil analisis matriks menunjukkan strategi yang efektif dan efisien adalah strategi nomor (1) dengan hasil tertinggi 5,3. Strategi yang dipilih adalah untuk meningkatkan usahatani kopi liberika melalui pemanfaatan teknologi.
Data-driven digital health technologies in the remote clinical care of diabetic foot ulcers: a scoping review
Authors: Lazarus Joel , Cioroianu Iulia , Ehrhardt Beate , Gurevich David , Kreusser Lisa , Metcalfe Benjamin , Nishtala Prasad , Preatoni Ezio , Sharp Tamsin H. 
Published: September 2023

BackgroundThe availability and effectiveness of Digital Health Technologies (DHTs) to support clinicians, empower patients, and generate economic savings for national healthcare systems are growing rapidly. Of particular promise is the capacity of DHTs to autonomously facilitate remote monitoring and treatment. Diabetic Foot Ulcers (DFUs) are characterised by high rates of infection, amputation, mortality, and healthcare costs. With clinical outcomes contingent on activities that can be readily monitored, DFUs present a promising focus for the application of remote DHTs.ObjectiveThis scoping review has been conducted as a first step toward ascertaining fthe data-related challenges and opportunities for the development of more comprehensive, integrated, and individualised sense/act DHTs. We review the latest developments in the application of DHTs to the remote care of DFUs. We cover the types of DHTs in development and their features, technological readiness, and scope of clinical testing.Eligibility criteriaOnly peer-reviewed original experimental and observational studies, case series and qualitative studies were included in literature searches. All reviews and manuscripts presenting pre-trial prototype technologies were excluded.MethodsAn initial search of three databases (Web of Science, MEDLINE, and Scopus) generated 1,925 English-language papers for screening. 388 papers were assessed as eligible for full-text screening by the review team. 81 manuscripts were found to meet the eligibility criteria.ResultsOnly 19% of studies incorporated multiple DHTs. We categorised 56% of studies as ‘Treatment-Manual’, i.e. studies involving technologies aimed at treatment requiring manual data generation, and 26% as ‘Prevention-Autonomous’, i.e. studies of technologies generating data autonomously through wearable sensors aimed at ulcer prevention through patient behavioural change. Only 10% of studies involved more ambitious ‘Treatment-Autonomous’ interventions. We found that studies generally reported high levels of patient adherence and satisfaction.ConclusionsOur findings point to a major potential role for DHTs in remote personalised medical management of DFUs. However, larger studies are required to assess their impact. Here, we see opportunities for developing much larger, more comprehensive, and integrated monitoring and decision support systems with the potential to address the disease in a more complete context by capturing and integrating data from multiple sources from subjective and objective measurements.
Racial differences in setting of implantable cardioverter-defibrillator placement in older adults with heart failure and association with disparate post-implant outcomes
Authors: Akhabue Ehimare , Kuhrt Nathaniel , Gandhi Poonam , Rua Melanie , Shalmon Uri , Visaria Aayush , Jackson Larry R , Setoguchi Soko 
Published: September 2023

BackgroundImplantable cardioverter-defibrillator (ICD) placement in heart failure (HF) patients during or early after (≤90 days) unplanned cardiovascular hospitalizations has been associated with poor outcomes. Racial and ethnic differences in this “peri-hospitalization” ICD placement have not been well described.MethodsUsing a 20% random sample of Medicare beneficiaries, we identified older (≥66 years) patients with HF who underwent ICD placement for primary prevention from 2008 to 2018. We investigated racial and ethnic differences in frequency of peri-hospitalization ICD placement using modified Poisson regression. We utilized Kaplan-Meier analyses and Cox regression to investigate the association of peri-hospitalization ICD placement with differences in all-cause mortality and hospitalization (HF, cardiovascular and all-cause) within and between race and ethnicity groups for up to 5-year follow-up.ResultsAmong the 61,710 beneficiaries receiving ICDs (35% female, 82% White, 10% Black, 6% Hispanic), 44% were implanted peri-hospitalization. Black [adjusted rate ratio (RR) 95% Confidence Interval (95% CI): 1.16 (1.12, 1.20)] and Hispanic [RR (95% CI): 1.10 (1.06, 1.14)] beneficiaries were more likely than White beneficiaries to have ICD placement peri-hospitalization. Peri-hospitalization ICD placement was associated with an at least 1.5× increased risk of death, 1.5× increased risk of re-hospitalization and 1.7× increased risk of HF hospitalization during 3-year follow-up in fully adjusted models. Although beneficiaries with peri-hospitalization placement had the highest mortality and readmission rates 1- and 3-year post-implant (log-rank p &lt; 0.0001), the magnitude of the associated risk did not differ significantly by race and ethnicity (p = NS for interaction).ConclusionsICD implantation occurring during the peri-hospitalization period was associated with worse prognosis and occurred at higher rates among Black and Hispanic compared to White Medicare beneficiaries with HF during the period under study. The risk associated with peri-hospitalization ICD placement did not differ by race and ethnicity. Future paradigms aimed at enhancing real-world effectiveness of ICD therapy and addressing disparate outcomes should consider timing and setting of ICD placement in HFrEF patients who otherwise meet guideline eligibility.
The impact of on-site cardiac surgical backup on clinical outcomes of acute coronary syndrome—analysis of the ACSIS national registry
Authors: Moady Gassan , Ovdat Tal , Rubinshtein Ronen , Eitan Amnon , Daud Elias , Arow Ziad , Atar Shaul 
Published: September 2023

BackgroundThe availability of advanced technologies for mechanical support in hospitals with on-site cardiac surgery (CS), along with the ability to perform urgent coronary artery bypass graft (CABG) surgery, may result in improved clinical outcomes in patients with acute coronary syndrome (ACS).MethodsWe conducted a retrospective analysis of the bi-annually Acute Coronary Syndrome Israeli Survey (ACSIS) registry from the year 2000 to 2020, performed in hospitals with and without CS. Mortality rates and major adverse cardiac and cerebrovascular events (MACCE) rates are reported. We evaluated two periods of the study—early (2000–2010) vs. late (2011–2020). Propensity score matching was performed to reduce bias between the two groups.ResultsThe study included 16,979 patients (52.3% in the on-site CS group). Patients in the on-site CS group were more likely to undergo percutaneous coronary intervention (PCI), (odds ratio [OR], 1.26 [95% CI, 1.18–1.35]; p &lt; 0.001) and CABG [OR, 1.91 (95%CI, 1.63–2.24); P &lt; 0.001], and patients in hospitals without on-site CS had higher 30-day MACCE [OR, 1.17 (95% CI, 1.07–1.27); p &lt; 0.0005]. Overall, there was no difference in 1-year mortality (hazard ratio [HR], 0.98 [95% CI, 0.89–1.08]; p = 0.71) between the groups. During the late period of the study, patients in the group without on-site CS had lower 30-day mortality [OR, 0.69 (95% CI, 0.49–0.97); P = 0.04], yet with no difference in 1-year mortality [HR, 0.81 (95% CI, 0.65–1.01); p = 0.07].ConclusionsThe availability of on-site CS resulted in variations in treatment modality, yet it did not affect the clinical outcomes of ACS. A trend to a better short-term outcomes was noted in hospitals without CS during the late period of the study, which warrants further investigation.
Breathing pattern and pulmonary gas exchange in elderly patients with and without left ventricular dysfunction—modification with exercise-based cardiac rehabilitation and prognostic value
Authors: Eser Prisca , Marcin Thimo , Prescott Eva , Prins Leonie F. , Kolkman Evelien , Bruins Wendy , van der Velde Astrid E. , Gil Carlos Peña , Iliou Marie-Christine , Ardissino Diego , Zeymer Uwe , Meindersma Esther P. , Van’t Hof Arnoud W. J. , de Kluiver Ed P. , Wilhelm Matthias 
Published: September 2023

BackgroundInefficient ventilation is an established prognostic marker in patients with heart failure. It is not known whether inefficient ventilation is also linked to poor prognosis in patients with left ventricular dysfunction (LVD) but without overt heart failure.ObjectivesTo investigate whether inefficient ventilation in elderly patients with LVD is more common than in patients without LVD, whether it improves with exercise-based cardiac rehabilitation (exCR), and whether it is associated with major adverse cardiovascular events (MACE).MethodsIn this large multicentre observational longitudinal study, patients aged ≥65 years with acute or chronic coronary syndromes (ACS, CCS) without cardiac surgery who participated in a study on the effectiveness of exCR in seven European countries were included. Cardiopulmonary exercise testing (CPET) was performed before, at the termination of exCR, and at 12 months follow-up. Ventilation (VE), breathing frequency (BF), tidal volume (VT), and end-expiratory carbon dioxide pressure (PETCO2) were measured at rest, at the first ventilatory threshold, and at peak exercise. Ventilatory parameters were compared between patients with and without LVD (based on cardio-echography) and related to MACE at 12 month follow-up.ResultsIn 818 patients, age was 72.5 ± 5.4 years, 21.9% were women, 79.8% had ACS, and 151 (18%) had LVD. Compared to noLVD, in LVD resting VE was increased by 8%, resting BF by 6%, peak VE, peak VT, and peak PETCO2 reduced by 6%, 8%, and 5%, respectively, and VE/VCO2 slope increased by 11%. From before to after exCR, resting VE decreased and peak PETCO2 increased significantly more in patients with compared to without LVD. In LVD, higher resting BF, higher nadir VE/VCO2, and lower peak PETCO2 at baseline were associated with MACE.ConclusionsSimilarly to patients with HF, in elderly patients with ischemic LVD, inefficient resting and exercise ventilation was associated with worse outcomes, and ExCR alleviated abnormal breathing patterns and gas exchange parameters.
Clinical presentation and neurovascular manifestations of cardiac myxomas and papillary fibroelastomas: a retrospective single-institution cohort study
Authors: Mathavan Akshay , Mathavan Akash , Krekora Urszula , Mathavan Mohit , Rodriguez Vanessa , Altshuler Ellery , Nguyen Brianna , Ruzieh Mohammed 
Published: September 2023

BackgroundPrimary cardiac tumors are often benign and commonly present as cardiac myxomas (CMs) or papillary fibroelastomas (CPFEs). There is a paucity of prognostic indicators for tumor burden or potential for embolic cerebrovascular events (CVEs). This study was performed to address these gaps.MethodsMedical records at the University of Florida Health Shands Hospital between 1996 and 2021 were screened to identify patients with CMs or CPFEs. Clinical features, echocardiographic reports, and CVE outcomes were quantitatively assessed.ResultsA total of 55 patients were included in the study: 28 CM (50.9%) and 27 CPFE (49.1%) patients. Baseline patient characteristics were similar among patients. The neutrophil–lymphocyte ratio was correlated (p &lt; 0.005 in all cases) to three metrics of tumor size in both CM (r = 64–67%) and CPFE (r = 56–59%). CVEs were the presenting symptom in 30 (54.5%) patients. CVE recurrence was high; the 5-year CVE recurrence rate in patients with tumor resection was 24.0% compared to 60.0% without resection. No baseline patient characteristics or tumor features were associated with an initial presentation of CVEs compared to any other indication. Univariate analysis indicated that prolonged duration to surgical resection, left atrial enlargement, male sex, and a neutrophil–lymphocyte ratio &gt;3.0 at the follow-up were significantly associated with 5-year CVE recurrence. Left atrial enlargement and a neutrophil–lymphocyte ratio &gt;3.0 at the follow-up remained significantly associated with 5-year CVE recurrence in multivariate analysis.ConclusionThe neutrophil–lymphocyte ratio may prognosticate tumor size and recurrence of neurologic events. An increased risk of CVE within 5 years of mass resection is almost exclusive to patients initially presenting with CVEs.
Bathymetries of proglacial lakes: a new data set from the northern Tien Shan, Kazakhstan
Authors: Kapitsa Vassiliy , Shahgedanova Maria , Kasatkin Nikolay , Severskiy Igor , Kasenov Murat , Yegorov Alexandr , Tatkova Mariya 
Published: September 2023

Between 2009 and 2020, 74 bathymetric surveys of 57 glacial lakes were conducted in the northern Tien Shan using the ecosounding technique. The surveys provided data on lake depths and other parameters characterising the three-dimensional lake geometry, and bathymetrically derived lake volumes. The sample included 21 glacier-connected lakes, 27 lakes formed on the young moraines without glacier-connected with glacier tongue, eight lakes formed on the older moraines and one rock-dammed lake. The lakes’ volumes ranged between 0.029x105 and 53.89x105 m3 with the largest value of mean depth was 23 m. There is a statistically significant correlation between lake depth and width, length and area, best approximated by the power, linear, and polynomial models, with coefficients of determination ranging between 0.50 and 0.78 for the glacier-connected lakes. The power equations underestimated both depths and volumes of larger lakes but the second-order polynomial model provided a closer approximation in the study region. The obtained data were combined with the bathymetrically derived depth and volume data published in the literature extending the global data set of bathymetries of lakes with natural dams. The area-depth scaling equations derived from the combined data set showed a considerable improvement in correlation between area and depth in comparison with the earlier studies. The measured bathymetries of the glacier-connected lakes were compared with bathymetries of the same lakes simulated using GlabTOP2 model and published simulated ice thickness data. There is generally a good agreement between the measured and simulated bathymetries although GlabTOP2 tends to overestimate lake depths. The data from the bathymetric surveys and GlabTOP2 model are used by the practitioners to reduce and avoid risks associated with glacier lake outburst floods and are important instruments of the regional strategy of adaptation to climate change.
Ex-utero third trimester developmental changes in functional brain network organization in infants born very and extremely preterm
Authors: Cook Kevin M. , De Asis-Cruz Josepheen , Basu Sudeepta K. , Andescavage Nickie , Murnick Jonathan , Spoehr Emma , du Plessis Adré J. , Limperopoulos Catherine 
Published: September 2023

IntroductionThe latter half of gestation is a period of rapid brain development, including the formation of fundamental functional brain network architecture. Unlike in-utero fetuses, infants born very and extremely preterm undergo these critical maturational changes in the extrauterine environment, with growing evidence suggesting this may result in altered brain networks. To date, however, the development of functional brain architecture has been unexplored.MethodsFrom a prospective cohort of preterm infants, graph parameters were calculated for fMRI scans acquired prior to reaching term equivalent age. Eight graph properties were calculated, Clustering Coefficient (C), Characteristic Path Length (L), Modularity (Q), Local Efficiency (LE), Global Efficiency (GE), Normalized Clustering (λ), Normalized Path Length (γ), and Small-Worldness (σ). Properties were first compared to values generated from random and lattice networks and cost efficiency was evaluated. Subsequently, linear mixed effect models were used to assess relationship with postmenstrual age and infant sex.ResultsA total of 111 fMRI scans were acquired from 85 preterm infants born at a mean GA 28.93 ± 2.8. Infants displayed robust small world properties as well as both locally and globally efficient networks. Regression models found that GE increased while L, Q, λ, γ, and σ decreased with increasing postmenstrual age following multiple comparison correction (r2Adj range 0.143–0.401, p &lt; 0048), with C and LE exhibited trending increases with age.DiscussionThis is the first direct investigation on the extra-uterine formation of functional brain architecture in preterm infants. Importantly, our results suggest that changes in functional architecture with increasing age exhibit a different trajectory relative to in utero fetus. Instead, they exhibit developmental changes more similar to the early postnatal period in term born infants.