bluuebunny/crossref_metadata_2025_split huggingface dataset:
The zero suffix in English and Italian deverbal nouns
Authors: Iordăchioaia Gianina , Melloni Chiara 
Published: June 2023

AbstractIn this paper we bring evidence from English and Italian deverbal zero nominals (to climb>the climb-ØN) that zero is a possible spell-out of a nominalizer otherwise overtly instantiated in suffixed nominals (examin-ation). We argue in favor of a Distributed Morphology approach, a separationist theory that recognizes and easily implements zero morphology with underlying syntax-semantics. Abstracting away from other theoretical trends and their foundational reasons to refrain from using zero suffixes, we address three properties that have been argued to fundamentally distinguish zero nominals from overtly suffixed nominals, with the implication that they instantiate a different word formation process: i) realization of verbal argument structure, ii) possibility of embedding verbalizing suffixes, and iii) semantic transparency in relation to the verb. By means of corpus data and two manually collected datasets of 561 English and 174 Italian zero nominals based on lexicographic information, we bring solid evidence against these claims, by arguing that: i) a great proportion of zero nominals do realize verbal argument structure, ii) the zero affix may embed verbalizing affixes within the limits of the selectional restrictions it independently imposes on its base, and iii) zero nominals present the same patterns of polysemy that suffixed nominals display. However, we show that zero nominals also present some idiosyncrasies to the extent that not all of them express compositional event readings with argument structure, a matter that deserves further research within the frame of their competition with suffixed nominals.
The semantics of noun-to-verb zero-derivation in English and Spanish
Authors: Valera Salvador 
Published: June 2023

AbstractThe semantics of zero-derivation/conversion has attracted renewed interest both as a subject of description and as a means towards refined descriptions of the process. This paper takes the latter stance and compares which semantic categories occur in zero-derivation/conversion and in overt affixation in two languages with a different morphological model: English and Spanish. For attestation and distribution of the semantic categories, the paper relies on a stratified sample of denominal verbs collected from two comparable corpora: theBritish National Corpusand theCorpus de Referencia del Español Actual. The sample consists in sets of ca. 50 denominal verb-forming resources, one per affixation process, namely affixation by -ate, -(i)fy, -ize/-ise, -en,en- in English,a-…-ar,en-…-ar, -ear, -ecer, -(i)ficar, -izarin Spanish, and zero-derivation/conversion in both languages. The results are contrasted within and across affixes/processes, within each language and across the two languages for the adequacy of a description as zero-derivation or as conversion. Statistical analysis shows that the process/affixes form a cline with overlaps and closer associations between specific affixes/processes and semantic categories, but no clear divide between zero-derivation/conversion and the rest of processes as far as the semantic categories are concerned.
A Visual Pathway into Central Complex for High-Frequency Motion-Defined Bars inDrosophila
Authors: Duan Wenlan , Zhang Yihao , Zhang Xin , Yang Jihua , Shan Heying , Liu Li , Wei Hongying 
Published: June 2023

Relative motion breaks a camouflaged target from a same-textured background, thus eliciting discrimination of a motion-defined object. Ring (R) neurons are critical components in theDrosophilacentral complex, which has been implicated in multiple visually guided behaviors. Using two-photon calcium imaging with female flies, we demonstrated that a specific population of R neurons that innervate the superior domain of bulb neuropil, termed superior R neurons, encoded a motion-defined bar with high spatial frequency contents. Upstream superior tuberculo-bulbar (TuBu) neurons transmitted visual signals by releasing acetylcholine within synapses connected with superior R neurons. Blocking TuBu or R neurons impaired tracking performance of the bar, which reveals their importance in motion-defined feature encoding. Additionally, the presentation of a low spatial frequency luminance-defined bar evoked consistent excitation in R neurons of the superior bulb, whereas either excited or inhibited responses were evoked in the inferior bulb. The distinct properties of the responses to the two bar stimuli indicate there is a functional division between the bulb subdomains. Moreover, physiological and behavioral tests with restricted lines suggest that R4d neurons play a vital role in tracking motion-defined bars. We conclude that the central complex receives the motion-defined features via a visual pathway from superior TuBu to R neurons and might encode different visual features via distinct response patterns at the population level, thereby driving visually guided behaviors.SIGNIFICANCE STATEMENTAnimals could discriminate a motion-defined object that is indistinguishable with a same-textured background until it moves, but little is known about the underlying neural mechanisms. In this study, we identified that R neurons and their upstream partners, TuBu neurons, innervating the superior bulb ofDrosophilacentral brain are involved in the discrimination of high-frequency motion-defined bars. Our study provides new evidence that R neurons receive multiple visual inputs from distinct upstream neurons, indicating a population coding mechanism for the fly central brain to discriminate diverse visual features. These results build progress in unraveling neural substrates for visually guided behaviors.
Connecting Connectomes to Physiology
Authors: Borst Alexander , Leibold Christian 
Published: June 2023

With the advent of volumetric EM techniques, large connectomic datasets are being created, providing neuroscience researchers with knowledge about the full connectivity of neural circuits under study. This allows for numerical simulation of detailed, biophysical models of each neuron participating in the circuit. However, these models typically include a large number of parameters, and insight into which of these are essential for circuit function is not readily obtained. Here, we review two mathematical strategies for gaining insight into connectomics data: linear dynamical systems analysis and matrix reordering techniques. Such analytical treatment can allow us to make predictions about time constants of information processing and functional subunits in large networks.SIGNIFICANCE STATEMENTThis viewpoint provides a concise overview on how to extract important insights from Connectomics data by mathematical methods. First, it explains how new dynamics and new time constants can evolve, simply through connectivity between neurons. These new time-constants can be far longer than the intrinsic membrane time-constants of the individual neurons. Second, it summarizes how structural motifs in the circuit can be discovered. Specifically, there are tools to decide whether or not a circuit is strictly feed-forward or whether feed-back connections exist. Only by reordering connectivity matrices can such motifs be made visible.
NALCN‐mediated sodium influx confers metastatic prostate cancer cell invasiveness
Authors: Folcher Antoine , Gordienko Dmitri , Iamshanova Oksana , Bokhobza Alexandre , Shapovalov George , Kannancheri‐Puthooru Dheeraj , Mariot Pascal , Allart Laurent , Desruelles Emilie , Spriet Corentin , Diez Raquel , Oullier Thibauld , Marionneau‐Lambot Séverine , Brisson Lucie , Geraci Sandra , Impheng Hathaichanok , Lehen'kyi V'yacheslav , Haustrate Aurélien , Mihalache Adriana , Gosset Pierre , Chadet Stéphanie , Retif Stéphanie , Laube Maryline , Sobilo Julien , Lerondel Stéphanie , Villari Giulia , Serini Guido , Pla Alessandra Fiorio , Roger Sébastien , Fromont‐Hankard Gaelle , Djamgoz Mustafa , Clezardin Philippe , Monteil Arnaud , Prevarskaya Natalia 
Published: June 2023

AbstractThere is growing evidence that ion channels are critically involved in cancer cell invasiveness and metastasis. However, the molecular mechanisms of ion signaling promoting cancer behavior are poorly understood and the complexity of the underlying remodeling during metastasis remains to be explored. Here, using a variety of in vitro and in vivo techniques, we show that metastatic prostate cancer cells acquire a specific Na+/Ca2+ signature required for persistent invasion. We identify the Na+ leak channel, NALCN, which is overexpressed in metastatic prostate cancer, as a major initiator and regulator of Ca2+ oscillations required for invadopodia formation. Indeed, NALCN‐mediated Na+ influx into cancer cells maintains intracellular Ca2+ oscillations via a specific chain of ion transport proteins including plasmalemmal and mitochondrial Na+/Ca2+ exchangers, SERCA and store‐operated channels. This signaling cascade promotes activity of the NACLN‐colocalized proto‐oncogene Src kinase, actin remodeling and secretion of proteolytic enzymes, thus increasing cancer cell invasive potential and metastatic lesions in vivo. Overall, our findings provide new insights into an ion signaling pathway specific for metastatic cells where NALCN acts as persistent invasion controller.
Optimising prednisolone or prednisone replacement in adrenal insufficiency
Authors: Sharma Angelica , Lazarus Katharine , Papadopoulou Deborah , Prabhudev Hemanth , Tan Tricia , Meeran Karim , Choudhury Sirazum 
Published: June 2023

Context
Patients with adrenal insufficiency (AI) have a higher mortality than the general population, possibly because of excess glucocorticoid exposure at inappropriate times. The cortisol circadian rhythm is difficult to mimic with twice- or thrice-daily hydrocortisone. Prednisolone is a once-daily alternative which may improve patient compliance through its convenience.

Objectives
Prednisolone day curves can be used to accurately downtitrate patients to the minimum effective dose. This study aimed to review prednisolone day curves and determine therapeutic ranges at different time points after administration.

Methods
Between August 2013 and May 2021, 108 prednisolone day curves from 76 individuals receiving prednisolone replacement were analysed. Prednisolone concentrations were determined by ultra-high-performance liquid chromatography-tandem mass spectrometry. Spearman’s correlation coefficient was used to determine the relationship between 2-, 4-, and 6-h prednisolone levels compared to the previously validated standard 8-h prednisolone level (15–25 μg/L).

Results
The median dose was 4 mg of prednisolone once daily. There was a strong correlation between the 4- and 8-h (R = 0.8829, P ≤ 0.0001) and 6- and 8-h prednisolone levels (R = 0.9530, P ≤ 0.0001). Target ranges for prednisolone were 37–62 μg/L at 4 h, 24–39 μg/L at 6 h, and 15–25 μg/L at 8 h. Prednisolone doses were successfully reduced in 21 individuals, and of these, 3 were reduced to 2 mg once daily. All patients were well upon follow-up.

Conclusion
This is the largest evaluation of oral prednisolone pharmacokinetics in humans. Low-dose prednisolone of 2–4 mg is safe and effective in most patients with AI. Doses can be titrated with either 4-, 6-, or 8-h single time point drug levels.
Decarbonization challenges and opportunities in the Central European energy sector: Implications for management
Authors: Magyari József 
Published: June 2023

AbstractWhile decarbonization and hydrogen energy are at the top of European policymakers' agenda, research and innovation (R&I) management of energy companies must focus on clean technologies (cleantech) which could decrease greenhouse gas (GHG) emissions in the sector. The Central European energy sector, however, might face a decarbonization challenge because of the specific geopolitical situation, so aligning R&I directions with regional policy and conditions seem to be crucial to accelerate sectoral and corporate adaptation. This study focuses on the decarbonization progress and strategies of the Visegrád 4 (V4) countries, concerning some of the most promising hydrogen-driven cleantech R&I directions which might induce strategic changes in Central European energy companies. Besides promoting renewable energy sources, results show that V4 strategies usually include the development of nuclear energy capacities to reduce GHG emissions and using the extended natural gas infrastructure for renewable energy storage. The analysed cleantech innovations are included but usually not central in these strategies. Strategic changes in energy companies, however, could be driven by these promising R&I directions, e.g., the hydrogen economy development by power-to-X (P2X) technologies, industrial decarbonization by carbon capture, utilization or storage (CCUS) technologies in the mid-term, and cross-sectoral integration and optimization by smart energy system (SES) development in the long-term.
Lateral-torsional buckling resistance of corrugated web girders
Authors: Bärnkopf Erzsébet , Jáger Bence , Kövesdi Balázs 
Published: June 2023

AbstractThere is currently no accurate calculation procedure for determining the lateral-torsional buckling resistance of trapezoidally corrugated web girders. Therefore, a detailed investigation is performed in the frame of an experimental and numerical research program at the Department of Structural Engineering of the Budapest University of Technology and Economics. Based on the previous experimental results, a numerical model is developed to be used to determine the lateral-torsional buckling resistance by using deterministic method. The effect of flange size, corrugation geometry and boundary conditions are investigated. An improved design method is developed for the determination of the lateral-torsional buckling resistance of trapezoidally corrugated web girders.
Improvement of protective oxide layers formed by high-frequency plasma electrolytic oxidation on Mg-RE alloy with LPSO-phase
Authors: Cheretaeva Alisa O. , Glukhov Pavel A. , Shafeev Marat R. , Denisova Alyona G. , Borgardt Eugeny D. , Polunin Anton V. , Katsman Alexander V. , Krishtal Mikhail M. 
Published: June 2023

Oxide layers on Mg97Y2Zn1 magnesium alloy with strengthening LPSO-phase were formed by plasma electrolytic oxidation (PEO) in bipolar mode with frequency variation of forming current pulses (50 and 500 Hz) and addition of sodium aluminate or sodium silicate to alkali phosphate fluoride electrolyte. Microstructure, chemical and phase composition, corrosion and mechanical properties of the oxide layers formed were investigated. With increasing current frequency for both electrolytes, an increase in homogeneity of the oxide layers structure and a decrease in their porosity and fracturing at constant thickness were recorded. The oxide layers formed at 500 Hz even with some decrease in hardness have better adhesive strength and 2 orders of magnitude higher short-term corrosion resistance values. PEO of Mg-alloy with LPSO-phase in the electrolyte with addition of sodium aluminate in combination with increased pulse frequency (500 Hz) allows forming the best-quality uniform oxide layer with high hardness, adhesive strength and corrosion resistance properties. The use of electrolyte with addition of sodium silicate reduced the adhesive strength by 1.5 times and brought down the long-term corrosion resistance of oxide layers by an order of magnitude, as compared with the electrolyte with sodium aluminate. The reason for a significant improvement in the complex of protective properties of the oxide layers with an increase in the current pulse frequency is supposed to be a decrease in the power and duration of individual microarc discharges with simultaneous increase in their number per unit oxidized area.
Determinants of neonatal mortality in Margaret Kenyatta Mother Baby Wing at Nakuru level 5 hospital, Nakuru County, Kenya
Authors: Ndungu Wainaina D. , Mogere Dominic M. , Atei Kerochi 
Published: June 2023

Background: Nakuru county has 41.9 neonatal deaths per 1000 live births, more than double the national average of 19. This study examined Nakuru level 5 hospital neonatal mortality risk factors.
Methods: A retrospective mismatched case-control study was used. The 429 neonates (143 cases and 286 controls) were estimated assuming a 1:2 case-to-control ratio and 18% prevalence of exposure among controls. Binary logistic regression measured dependent-independent variable correlation.
Results: The study found that high parity, high number of stillbirths, positive HIV, HBsAg, syphilis, pregnancy-induced hypertension, antepartum hemorrhage, PROM 18hours, and maternal peri-partum increased the risk of neonatal. Similarly, mothers who had fewer ANC visits throughout their pregnancy had a higher risk of neonatal mortality compared to mothers who attended more than three ANC clinics, with mortality risk reducing by 69% and 59% for 1-2 visits and more than 3 visits, respectively, compared to non-attendance. Vaginal aided birth had an or of 2.188 and vaginal unassisted OR=4.533 compared to caesarian delivery. Antibiotics and prenatal dexamethasone decreased maternal mortality. Antibiotics lowered NMR or 0.381. Newborns admitted from referral facilities or labor wards had or 1.11 and or 6.220 death rates. Low birth weight, admission weight, gain weeks, and congenital defects increased mortality. In this study, birthweight decreased newborn mortality.
Conclusions: The study concluded that maternal characteristics, neonatal complications are key to improving neonatal outcomes. The study recommends regular training of staff working in the maternity and newborn unit on emergency care and neonatal resuscitation.
Anode Biofilm Formation With Applied External Voltage
Authors: Koltysheva Dina , Shchurska Kateryna , Kuzminskyi Yevhenii 
Published: June 2023

Background. The formation of an exoelectrogenic biofilm in a microbial fuel cell (MFC) is an important stage, because it affects later on current generation by the system. The fermented residue after methanogenesis as an inoculum contains not only exoelectrogenic microorganisms, but also methanogens, which reduce the productivity of MFC. The use of current allows the formation of a biofilm enriched with exoelectrogenic microorganisms.
Objective. The purpose of our study was to establish the parameters of MFC under periodic application of external voltage.
Methods. A two-chamber H-type MFC with a salt bridge between the chambers was used for the study. The anolyte was stirred with a magnetic stirrer for 4 h a day and a 3V voltage was simultaneously applied to create selective conditions for exoelectrogenic biofilm growth.
Results. The application of external voltage stimulated the increase in the current and voltage of the MFC. With the periodic application of an external voltage, the MFC current increased to 788 ± 40 mA for the MFC with a resistor and without load. After disconnection and discharge, the MFC current dropped to 189 ± 10 mA for the MFC without load and to 154 ± 8 mA for the MFC with a resistor, respectively. Under the conditions of MFC operation without applying external voltage, the current was 960 ± 50 mA for MFC with an open circuit and 672 ± 35 mA for MFC with a closed circuit when a resistor is connected. For all MFC, the current gradually decreased over time. MFC demonstrated capacitive behaviour: after accumulating charge for 4 h, a discharge from 622 ± 30 mV to 462 ± 23 mV was observed. Microscopy showed fouling of the anode. Since the fermented residue after methanogenesis is mixed consortium, the anodic biofilm was also mixed consortium enriched with different species of exoelectrogens.
Conclusions. Periodic application of external voltage allowed to increase the current by 17% and double the voltage compared to MFC without external voltage supply. However, after disconnecting the external voltage source, the MFC gradually discharged, that is, the current and voltage decreased. The maximum value of the current of the MFC with an open circuit was 22% more than the MFC with a closed circuit.
Critical Discourse Analysis of Theo Van Leeuwen's Inclussion Theory on Anti-Crime Editorials in Daily Newspapers Pos Kota February 2020 Edition
Authors: Bagus Hady Hartanto  , Erlina Chamalia Rochmah  , Goziyah Goziyah 
Published: June 2023

This research aims to describe the author's attitudes and views on the common criminality of Indonesia in recent times, which is embodied in anticriminality. The research focuses on the preaching of the crime that is found in the Postal City daily issue of February 2020 by using a study analysis of the critical discourse of Theo Van Leeuwen. The type of research used in this study is qualitative research using the methods of content analysis. The data source used in this study is criminality news found in the Postal city newspaper February 23, 2020. The research Data uses the five news stories in the City Post's daily newspaper with a theme of criminality. Based on the results of the study it can be concluded that Leeuwen's inclusion strategy was found in the Post Kota newspaper's February issue of 2020 with an anti-criminality theme of seven sentencesthat is (1) assimilation, (2) determinations, (3) dissociation, (4) The identification of, (5) Individualization, (6) identifications, (7) categorisation.
Keywords : Inclusion, Criminality, Post Kota, Daily NewsPaper.
Homogeneity of Bored Piles According to Results of Four-Channel Cross-Well Ultrasonic Monitoring
Authors: Snezhkov D. Yu. , Leonovich S. N. , Budrevich N. A. 
Published: June 2023

The homogeneity of the structure of the boired pile shaft has been studied based on the results of four-channel inter-well ultrasonic (US) monitoring. The actual lengthy of the piles has been determined with the detection of defragmentation of the pile shaft, the compressive defects have been determined, and continuity defects have been identified based on a joint analysis of data from the method of interwell ultrasonic monitoring. The use of four channels allows to control separately the peripheral and central areas of the pile in six directions. The data of the seismoacoustic method coincided with the parameters of ultrasonic monitoring in terms of identifying zones of concrete heterogeneity, reducing the pile cross section, etc. For all of the listed piles, data are not registered by the named test methods indicating defragmentation of the pile shaft – the presence of sections in the cross sections of which there is no concrete at all. These test methods for all piles confirmed the compliance of their actual length with the design values. A significant defect in the continuity of the concrete of the 40op pile, according to the data of ultrasonic monitoring and seismoacoustic method, was registered in the interval of marks – (17.5–18) m, manifesting itself a sa decrease in the propagation velocity of the ultrasonic pulse from 25 to 50 % in two sounding directions, inclu-ding diametrical. This defect can be interpreted as a decrease in the effective section of the pile to 25–50 % of the average value. Defective sections of piles were found in their upper part at depth marks from 0 to –1.5 m, counting from the end surface of the head. At the same time, differences in the physical and mechanical parameters of concrete at these marks were also observed within the cross section of piles [1–5].