Effectiveness and tolerability of dolutegravir/lamivudine for the treatment of HIV-1 infection in clinical practice
Authors: Suárez-García Inés , Alejos Belén , Hernando Victoria , Viñuela Laura , Vera García Mar , Rial-Crestelo David , Pérez Elías María Jesús , Albendín Iglesias Helena , Peraire Joaquim , Tiraboschi Juan , Díaz Asunción , Moreno Santiago , Jarrín Inma ,   the Cohort of the Spanish HIV/AIDS Research Network (CoRIS), Moreno Santiago , Jarrín Inma , Dalmau David , Navarro M Luisa , González M Isabel , Garcia Federico , Poveda Eva , Iribarren Jose Antonio , Gutiérrez Félix , Rubio Rafael , Vidal Francesc , Berenguer Juan , González Juan , Muñoz-Fernández M Ángeles , Jarrín Inmaculada , Moreno Cristina , Rava Marta , Izquierdo Rebeca , del Romero Raposo Jorge , Marco Cristina , Puente Julián , Muñoz-Fernández M Ángeles , Mauleón Elba , Juárez Roxana , Portilla Joaquín , Portilla Irene , Merino Esperanza , García Gema , Agea Iván , Sánchez-Payá José , Rodríguez Juan Carlos , Giner Livia , Reus Sergio , Boix Vicente , Torrus Diego , Pérez Verónica , Portilla Julia , Alemán María Remedios , Hernández Jehovana , Lirola Ana López , García Dácil , Díaz-Flores Felicitas , Alonso M Mar , Pelazas Ricardo , Asensi Víctor , Rivas M Eugenia , Suarez-Zarracina Tomás , Valle-Garay Eulalia , Díaz Javier , Pulido Federico , Rubio Rafael , Bisbal Otilia , Hernando M Asunción , Rial David , de Lagarde María , Arce Octavio , Pinto Adriana , Bermejo Laura , Santacreu Mireia , Navarro Roser , Gonzalez Candela , Iribarren Jose Antonio , Aramburu M José , Camino Xabier , von Wichmann Miguel Ángel , Goenaga Miguel Ángel , Bustinduy M Jesús , Azkune Harkaitz , Ibarguren Maialen , Kortajarena Xabier , Álvarez-Rodriguez Ignacio , Gil Leire , Martínez Lourdes , Gutiérrez Félix , Masiá Mar , Robledano Catalina , Padilla Sergio , Abellán Javier Garcia , Mascarell Paula , Adsuar Araceli , Pascual Rafael , Carvajal Mar , Fernández Marta , García José Alberto , Botella Ángela , de la Rica Alba , Ding Carolina , García-Sánchez Lidia , Ena Nuria , Barber Xavier , Agullo Vanessa , Pascual Reyes , Telenti Guillermo , Guillén Lucia , López Leandro , Vallejo Jennifer , Gonzalo-Jimenez Nieves , Ruiz Montserrat , Galiana Antonio , Muga Roberto , Sanvisens Arantza , Fuster Daniel , de Quirós Juan Carlos López Bernaldo , Gutierrez Isabel , Ramírez Margarita , Padilla Belén , Gijón Paloma , Aldamiz-Echevarría Teresa , Tejerina Francisco , Diez Cristina , Pérez Leire , Fanciulli Chiara , Corral Saray , Peraire Joaquín , Martí Anna , Viladés Consuelo , Vargas Montserrat , Olona Montserrat , Rull Anna , Alba Verónica , Yeregui Elena , Masip Jenifer , García-Pardo Graciano , Bertomeu Frederic Gómez , Espineira Sonia , Montero Marta , Blanes Marino , Tasias María , Calabuig Eva , Salavert Miguel , Fernández Juan , Segarra Inmaculada , González-García Juan , Delgado-Hierro Ana , Arribas José Ramón , Arribas Victor , Bernardino Jose Ignacio , Busca Carmen , Cano Joanna , Cadiñanos Julen , Castro Juan Miguel , Escosa Luis , Falces Iker , Herranz Pedro , Hontañón Victor , García Milagros , González-Baeza Alicia , Martín-Carbonero M Luz , Mayoral Mario , Mellado Mª Jose , Micán Rafael , de Miguel Rosa , Montejano Rocío , Montes M Luisa , Moreno Victoria , Rodés Luis Ramos Berta , Sainz Talía , Sendagorta Elena , Valencia Eulalia , Blanco Jose Ramón , Pérez-Martínez Laura , Oteo José Antonio , Ibarra Valvanera , Metola Luis , Sanz Mercedes , Martínez Rosa , Sampériz Gloria , Dalmau David , Martinez Marina , Jaén Angels , Cairó Mireia , Martinez-Lacasa Javier , Font Roser , Gisbert Laura , Rivero María , Piérola Beatriz , Goikoetxea Maider , Gracia María , Ibero Carlos , Moreno Estela , Repáraz Jesús , Navarro Gemma , Garcia Manel Cervantes , Isbert Sonia Calzado , Vilasaro Marta Navarro , Garcia Belen Lopez , de los Santos Ignacio , de los Santos Alejandro , Sanz Jesús , García-Fraile Lucio , Martín Enrique , Sánchez-Cerrillo Ildefonso , Calvet Marta , Barrios Ana , Bautista Azucena , Sáez Carmen , Ciudad Marianela , Gutiérrez Ángela , Moreno Santiago , del Campo Santos , Casado José Luis , Dronda Fernando , Moreno Ana , Pérez M Jesús , Serrano Sergio , Vivancos M Jesús , Martínez-Sanz Javier , Vallejo Alejandro , Sanchez Matilde , Pérez-Molina Jose Antonio , Hermida José Manuel , Bernal Enrique , Alcaraz Antonia , Bravo Joaquín , Muñoz Ángeles , Tomás Cristina , Martínez Mónica , Villalba M Carmen , García Federico , Martínez Clara , Hernández José , Medina Leopoldo Muñoz , Álvarez Marta , Chueca Natalia , Vinuesa David , de Salazar Adolfo , Fuentes Ana , Guirao Emilio , Viñuela Laura , Ruiz-Sancho Andrés , Anguita Francisco , Del Romero Jorge , Raposo Montserrat , Rodríguez Carmen , Puerta Teresa , Carrió Juan Carlos , Vera Mar , Ballesteros Juan , Ayerdi Oskar , Baza Begoña , Orviz Eva , Antela Antonio , Losada Elena , Riera Melchor , Peñaranda María , Ribas M Angels , Campins Antoni A , Garcia-Gazalla Mercedes , Fanjul Francisco J , Murillas Javier , Homar Francisco , Vilchez Helem H , Martin Luisa , Payeras Antoni , Santos Jesús , López María , Gómez Cristina , Viciana Isabel , Palacios Rosario , López-Cortés Luis Fernando , Espinosa Nuria , Roca Cristina , Llaves Silvia , Tiraboschi Juan Manuel , Imaz Arkaitz , Silva Ana Karina , Saumoy María , Scévola Sofía Catalina , Curran Adrián , Falcó Vicenç , Navarro Jordi , Burgos Joaquin , Suanzes Paula , García Jorge , Descalzo Vicente , Álvarez Patricia , Planas Bibiana , Sanchiz Marta , Rodríguez Lucía , Olalla Julián , Sánchez M José , Pérez Javier , del Arco Alfonso , de la Torre Javier , Prada José Luis , Martínez Onofre Juan , Martinez Lorena , Vera Francisco Jesús , García Josefina , Alcaraz Begoña , Guirao Antonio Jesús Sánchez , Mena Álvaro , Castro Ángeles , Pernas Berta , Vázquez Pilar , López Soledad , Ibarra Sofía , García Guillermo , Mirena Josu , Ferrero Oscar Luis , López Josefina , Cámara M Mar , de la Peña Mireia , Lopez Miriam , Lopez Iñigo , Lombide Itxaso , Polo Victor , de Miguel Joana , Galera Carlos , Fernández Marian , Albendin Helena , Castillo Antonia , Iborra Asunción , Moreno Antonio , Merlos M Angustias , Vidal Asunción , Amador Concha , Pasquau Francisco , Gil Concepción , Algado Jose Tomás , Suarez-García Inés , Malmierca Eduardo , González-Ruano Patricia , Ruiz M Pilar , Pascual José Francisco , Balsalobre Luz , Somodevilla Ángela , López M Villa , Omar Mohamed , Herrero Carmen , Gómez M Amparo , de Zarraga Miguel Alberto , Pérez Desiré , Estrada Vicente , Sanz Nieves , Cabello Noemí , Vergas Jorge , Núñez M Jose , Sagastagoitia Iñigo , Homen Reynaldo , Muñoz Ana , Górgolas Miguel , Cabello Alfonso , Álvarez Beatriz , Prieto Laura , Carrillo Irene , Al-Hayani Aws , Sanz José , Arranz Alberto , Hernández Cristina , Novella María , Galindo M José , Ferrer Ana , Román Antonio Rivero , Ruíz Inma , Juárez Antonio Rivero , López Pedro , Machuca Isabel , Frías Mario , Camacho Ángela , Pérez Ignacio , Corona Diana , Pérez Ignacio , Corona Diana , Cervero Miguel , Torres Rafael , Sánchez Juan Macías , Rincón Pilar , Real Luis Miguel , Corma Anais , Fernández Marta , González-Serna Alejandro , Poveda Eva , Pérez Alexandre , Morano Luis , Miralles Celia , Ocampo Antonio , Pousada Guillermo , Patiño Lucía , Dueñas Carlos , Gutiérrez Sara , Tapia Elena , Novoa Cristina , Egües Xjoylin , Telleria Pablo 
Published: April 2023

Abstract

Objectives
To assess the effectiveness and tolerability of dolutegravir (DTG)/lamivudine (3TC) among treatment-naive and virologically suppressed treatment-experienced individuals in the multicentre cohort of the Spanish HIV/AIDS Research Network (CoRIS) during the years 2018–2021.

Methods
We used multivariable regression models to compare viral suppression (VS) [HIV RNA viral load (VL) &lt;50 copies/mL] and the change in CD4 cell counts at 24 and 48 (±12) weeks after initiation with dolutegravir/lamivudine or other first-line ART regimens.

Results
We included 2160 treatment-naive subjects, among whom 401 (18.6%) started with dolutegravir/lamivudine. The remaining subjects started bictegravir (BIC)/emtricitabine (FTC)/tenofovir alafenamide (TAF) (n = 949, 43.9%), DTG + FTC/tenofovir disoproxil fumarate (TDF) (n = 282, 13.1%), DTG/3TC/abacavir (ABC) (n = 255, 11.8%), darunavir (DRV)/cobicistat(COBI)/FTC/TAF (n = 147, 6.8%) and elvitegravir (EVG)/COBI/FTC/TAF (n = 126, 5.8%). At 24 and 48 weeks after starting dolutegravir/lamivudine, 91.4% and 93.8% of the subjects, respectively, achieved VS. The probability of achieving VS with dolutegravir/lamivudine was not significantly different compared with any other regimen at 24 or 48 weeks, with the exception of a lower chance of achieving VS at 24 weeks for DRV/COBI/FTC/TAF (adjusted OR: 0.47; 95% CI: 0.30–0.74) compared with dolutegravir/lamivudine.
For the analysis of treatment-experienced virally suppressed subjects we included 1456 individuals who switched to dolutegravir/lamivudine, among whom 97.4% and 95.5% maintained VS at 24 and 48 weeks, respectively. During the first 48 weeks after dolutegravir/lamivudine initiation, 1.0% of treatment-naive and 1.5% of treatment-experienced subjects discontinued dolutegravir/lamivudine due to an adverse event.

Conclusions
In this large multicentre cohort, effectiveness and tolerability of dolutegravir/lamivudine were high among treatment-naive and treatment-experienced subjects.