bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ischemic-Modified Albumin in Neonates with Congenital Heart Defects
Authors: Korkut Didem G. , Özlü Ferda , Atlı Gülizar , Yıldız Şule M. , Demir Fadli , Göçen Uğur , Yapıcıoğlu Hacer 
Published: December 2022

Objectives Ischemia-modified albumin (IMA) is a new biochemical marker of ischemia. We aimed to search blood IMA levels in neonates with congenital heart defects.
Study Design During the study period, patients diagnosed with congenital heart disease and newborns with a diagnosis of hyperbilirubinemia as a control group were included in the study. IMA level was analyzed using the IMA absorbance unit (ABSU) method.
Results In total, 57 newborns with congenital heart disease requiring cardiac operation for the study group and 38 newborns for the control group were included. There was no difference between the two groups in terms of gender, mode of delivery, and weeks of gestation. The average IMA values in the control group were 0.19 ± 0.09 ABSU. The prepostoperative mean IMA values of the patient group were 0.22 ± 0.07 and 0.23 ± 0.07 ABSU, respectively. Comparison of the postoperative IMA with the mean of the control group was statistically significant. Preoperative and postoperative IMA values of patients who have died due to primary heart disease and surgical complications were 0.21 ± 0.07 (0.08–0.32) ABSU and 0.25 ± 0.06 (0.12–0.36) ABSU, respectively. IMA levels were not statistically different between the two groups.
Conclusion Hypoxia and ischemia in congenital heart disease in the newborn period both preoperatively and postoperatively were important in prognosis. IMA was higher in the postoperative group. Many comprehensive studies are important in terms of preventing complications and decreasing mortality and morbidity by commenting on prognosis.
Key Points
Automated Decellularization of the Rodent Epigastric Free Flap: A Comparison of Sodium Dodecyl Sulfate–Based Protocols
Authors: Bengur Fuat Baris , Chen Lei , Schilling Benjamin K. , Komatsu Chiaki , Figlioli Grace M. , Marra Kacey G. , Kokai Lauren E. , Solari Mario G. 
Published: December 2022

AbstractBackground Free tissue transfer to cover complex wounds with exposed critical structures results in donor-site morbidity. Perfusion decellularization and recellularization of vascularized composite tissues is an active area of research to fabricate complex constructs without a donor site. Sodium dodecyl sulfate (SDS)-based protocols remain the predominant choice for decellularization despite the deleterious effects on tissue ultrastructure and capillary networks. We aimed to develop an automated decellularization process and compare different SDS perfusion times to optimize the protocol.Methods A three-dimensional-printed closed-system bioreactor capable of continuously perfusing fluid through the vasculature was used for decellularization. The artery and vein of rat epigastric fasciocutaneous free flaps were cannulated and connected to the bioreactor. Protocols had varying durations of 1% SDS solution (3, 5, and 10 days) followed by 1 day of 1% Triton X-100 and 1 day of 1x phosphate-buffered saline. The residual DNA was quantified. Microarchitecture of the constructs was assessed with histology, and the vascular network was visualized for qualitative assessment.Results The structural integrity and the microarchitecture of the extracellular matrix was preserved in the 3- and 5-day SDS perfusion groups; however, the subcutaneous tissue of the 10-day protocol lost its structure. Collagen and elastin structures of the pedicle vessels were not compromised by the decellularization process. Five-day SDS exposure group had the least residual DNA content (p < 0.001). Across all protocols, skin consistently had twice as much residual DNA over the subcutaneous tissues.Conclusion A compact and integrated bioreactor can automate decellularization of free flaps to bioengineer regenerative constructs for future use in reconstruction of complex defects. A decellularization protocol with 5 days of 1% SDS exposure was the most successful to keep the residual DNA content at a minimum while preserving the structural integrity of the tissues.
Hypomorphic and dominant-negative impact of truncated SOX9 dysregulates Hedgehog–Wnt signaling, causing campomelia
Authors: Au Tiffany Y. K. , Yip Raymond K. H. , Wynn Sarah L. , Tan Tiong Y. , Fu Alex , Geng Yu Hong , Szeto Irene Y. Y. , Niu Ben , Yip Kevin Y. , Cheung Martin C. H. , Lovell-Badge Robin , Cheah Kathryn S. E. 
Published: December 2022

Haploinsufficiency for SOX9, the master chondrogenesis transcription factor, can underlie campomelic dysplasia (CD), an autosomal dominant skeletal malformation syndrome, because heterozygousSox9null mice recapitulate the bent limb (campomelia) and some other phenotypes associated with CD. However, in vitro cell assays suggest haploinsufficiency may not apply for certain mutations, notably those that truncate the protein, but in these cases in vivo evidence is lacking and underlying mechanisms are unknown. Here, using conditional mouse mutants, we compared the impact of a heterozygousSox9null mutation (Sox9+/−) with theSox9+/Y440XCD mutation that truncates the C-terminal transactivation domain but spares the DNA-binding domain. While someSox9+/Y440Xmice survived, allSox9+/−mice died perinatally. However, the skeletal defects were more severe and IHH signaling in developing limb cartilage was significantly enhanced inSox9+/Y440Xcompared withSox9+/−. ActivatingSox9Y440Xspecifically in the chondrocyte–osteoblast lineage caused milder campomelia, and revealed cell- and noncell autonomous mechanisms acting on chondrocyte differentiation and osteogenesis in the perichondrium. Transcriptome analyses of developingSox9+/Y440Xlimbs revealed dysregulated expression of genes for the extracellular matrix, as well as changes consistent with aberrant WNT and HH signaling. SOX9Y440Xfailed to interact with β-catenin and was unable to suppress transactivation ofIhhin cell-based assays.We propose enhanced HH signaling in the adjacent perichondrium induces asymmetrically localized excessive perichondrial osteogenesis resulting in campomelia. Our study implicates combined haploinsufficiency/hypomorphic and dominant-negative actions of SOX9Y440X, cell-autonomous and noncell autonomous mechanisms, and dysregulated WNT and HH signaling, as the cause of human campomelia.
Secondary epitaxy of high Sn fraction GeSn layer on strain-relaxed GeSn virtue substrate by molecular beam epitaxy
Authors: Qian Kun , Wu Songsong , Qian Jinhui , Yang Kaisen , An Yuying , Cai Hongjie , Lin Guangyang , Wang Jianyuan , Xu Jianfang , Huang Wei , Chen Songyan , Li Cheng 
Published: December 2022

Abstract
Strain relaxation is critical for GeSn alloys transforming from indirect to direct bandgap nature with Sn fraction above 6.5%, but difficult for them grown by molecular beam epitaxy (MBE), in which low temperature has to be set up to avoid Sn segregation. In this work, compressively strained Ge0.935Sn0.065 thin films grown on Si with a Ge buffer layer by MBE are firstly treated by ex-situ rapid thermal annealing, rendering partially strain relaxation in the Ge0.935Sn0.065 by generation of misfit dislocation networks without Sn segregation. Then, secondary epitaxy of Ge0.905Sn0.095 layer is carried out on the thermally annealed Ge0.935Sn0.065 virtual substrate. The secondary epitaxial GeSn layers exhibit partial strain relaxation and strong photoluminescence with red-shift of peak position, compared to that of fully compressive strained GeSn thin films with the same structure grown primary epitaxially. Those results manifest that secondary epitaxy, combining with ex-situ rapid thermal annealing for strain relaxed GeSn virtual substrate, is a practical way to achieve strain relaxed GeSn thin films with direct bandgap nature by MBE.
Skyrmion based 3D low complex runtime reconfigurable architecture design methodology of universal logic gate
Authors: Sivasubramani Santhosh , Paikaray Bibekananda , Kuchibhotla Mahathi , Haldar Arabinda , Murapaka Chandrasekhar , Acharyya Amit 
Published: December 2022

Abstract
In this study, we introduce the area efficient low complex runtime reconfigurable architecture design methodology based on Skyrmion logic for universal logic gate (ULG) i.e. NOR/NAND implementation using micromagnetic simulations. We have modelled the two input 3D device structure using bilayer ferromagnet/heavy metal where the magnetic tunnel junctions inject and detect the input and output skyrmions by exploiting the input reversal mechanism. The implementation of NOR and NAND is performed using this same device where it is reconfigured runtime with enhanced tunability by the ON and OFF state of current passing through a non magnetic metallic gate respectively. This gate acts as a barrier for skyrmion motion (additional control mechanism) to realize the required Skyrmion logic output states. To the best of authors’s knowledge the boolean optimizations and the mapping logic have been presented for the first time to demonstrate the functionalities of the NOR/NAND implementation. This proposed architecture design methodology of ULG leads to reduced device footprint with regard to the number of thin film structures proposed, low complexity in terms of fabrication and also providing runtime reconfigurability to reduce the number of physical designs to achieve all truth table entries (∼75% device footprint reduction). The proposed 3D ULG architecture design benefits from the miniaturization resulting in opening up a new perspective for magneto-logic devices.
Ultrasensitive self-powered heterojunction ultraviolet photodetector of p-GaN nanowires on Si by halide chemical vapour deposition
Authors: Anbarasan N , Sadhasivam S , Jeganathan K 
Published: December 2022

Abstract
In this study, we report the fabrication of quasi-aligned p-GaN nanowires (NWs) on n-Si (1 1 1) substrate by halide chemical vapour deposition (HCVD) using MgCl2 precursor and followed by low-energy electron beam irradiation to activate the Mg acceptor doping in GaN NWs. We aimed to attain a comprehensive understanding of p-doping in GaN NWs growth, extensive characterizations and fabrication of UV photodetector (PDs) based on p-GaN NWs/n-Si heterojunction. To realize the efficient UV photodetectors, we measure the current–voltage (I–V) characteristics of heterojunction PDs under dark and illuminated conditions and the I–V curve demonstrates good rectifying behaviours with 0.2 V turn-on voltage. At zero bias, the heterojunction PDs show a reverse photocurrent of 1.27 × 10−6 A with a very low dark current of 2.35 × 10−9 A under 325 nm UV illumination. Besides, the significance of the self-powered operation of UV PDs and the charge transfer mechanism are discussed with the aid of the energy band diagram. The substantial photocurrent increment with varying applied potential leads to narrowing the photo potential in the interface. The excitonic bound states present in p-GaN NWs/n-Si heterojunction is further elucidated. As a result, the heterojunction PDs demonstrate the high responsivity, detectivity, and external quantum efficiency of 134 mA W−1, 3.73 × 1013 Jones, and 51% respectively, at 0.1 V low applied potential under the reverse bias condition. The proposed work provides an archetype for Mg doping in GaN NWs ensembles, which will help to facilitate the heterojunction with n-Si to unleash the potential of self-powered UV PDs.
Roadmap for precision preclinical x-ray radiation studies
Authors: Verhaegen Frank , Butterworth Karl T , Chalmers Anthony J , Coppes Rob P , de Ruysscher Dirk , Dobiasch Sophie , Fenwick John D , Granton Patrick V , Heijmans Stefan H J , Hill Mark A , Koumenis Constantinos , Lauber Kirsten , Marples Brian , Parodi Katia , Persoon Lucas C G G , Staut Nick , Subiel Anna , Vaes Rianne D W , van Hoof Stefan , Verginadis Ioannis L , Wilkens Jan J , Williams Kaye J , Wilson George D , Dubois Ludwig J 
Published: December 2022

Abstract
This Roadmap paper covers the field of precision preclinical x-ray radiation studies in animal models. It is mostly focused on models for cancer and normal tissue response to radiation, but also discusses other disease models. The recent technological evolution in imaging, irradiation, dosimetry and monitoring that have empowered these kinds of studies is discussed, and many developments in the near future are outlined. Finally, clinical translation and reverse translation are discussed.
Catheter reconstruction and dosimetric verification of MRI-only treatment planning (MRTP) for interstitial HDR brachytherapy using PETRA sequence
Authors: Lee Casey Y , Kaza Evangelia , Harris Thomas C , O’Farrell Desmond A , King Martin T , Dyer Michael A , Cormack Robert A , Buzurovic Ivan 
Published: December 2022

Abstract

Objective. The feasibility of MRI-only treatment planning (MRTP) for interstitial high-dose rate (HDR) brachytherapy (BT) was investigated for patients diagnosed with gynecologic cancer. Approach. A clinical MRTP workflow utilizing a ‘pointwise encoding time reduction with radial acquisition (PETRA)’ sequence was proposed. This is a clinically available MRI sequence optimized to improve interstitial catheter-tissue contrast. Interstitial needles outside the obturator region were reconstructed using MR images only. For catheters penetrating through the obturator, a library-based reconstruction was proposed. In this work, dwell coordinates from the clinical CT-based reconstruction were used as the surrogate for the library-based approach. For MR-only plan, dwell times were activated and assigned as in the clinical plans. The catheter reconstruction was assessed by comparing dwell position coordinates. The dosimetric comparisons between a clinical plan and MR-only plan were assessed for physical and EQD2 dose and volume parameters for D
90, D
50 and D
98 for clinical target volume (CTV) and D
2cc, D
0.1cc and D
5cc for OARs. Main results. Catheter reconstruction was possible using the optimized PETRA sequence on MR images. An overall reconstruction difference of 1.7 ± 0.5 mm, attributed to registration-based errors, was found compared to the CT-based reconstruction. The MRTP workflow has the potential to generate a treatment plan with an equivalent dosimetric quality compared to the conventional CT/MRI-based approach. For CTV D
90, physical and EQD2 dose and volume parameter differences were 1.5 ± 1.9% and 0.7 ± 1.0 Gy, respectively. For D
2cc OARs, DVH (EQD2) differences were −0.4 ± 1.1% (−0.2 ± 0.5 Gy), 0.5 ± 2.8% (0.2 ± 1.3 Gy) and −0.5 ± 1.4% (−0.2 ± 0.5 Gy) for rectum, bladder, and sigmoid, respectively. Significance. With the proposed MRTP approach, CT imaging may no longer be needed in HDR BT for interstitial gynecologic treatment. A proof-of-concept study was conducted to demonstrated that MRTP using PETRA is feasible, with comparable dosimetric results to the conventional CT/MRI-based approach.
Forecast of Observing Time Delay of Strongly Lensed Quasars with the Muztagh-Ata 1.93 m Telescope
Authors: Zhu Shanhao , Shu Yiping , Yuan Haibo , Fu Jian-Ning , Gao Jian , Wu Jianghua , He Xiangtao , Liao Kai , Li Guoliang , Er Xinzhong , Hu Bin 
Published: December 2022

Abstract
As a completely independent method, the measurement of time delay of strongly lensed quasars (TDSL) are crucial to resolve the Hubble tension. Extensive monitoring is required but so far limited to a small sample of strongly lensed quasars. Together with several partner institutes, Beijing Normal University is constructing a 1.93 m reflector telescope at the Muztagh-Ata site in west China, which has the world class observing conditions with median seeing of 0.″82 and median sky brightness of 21.74

mag

arcsec

−
2

in V-band during the dark time. The telescope will be equipped with both a three-channel imager/photometer which covers 3500–11,000 Å wavelength band, and a low-medium resolution (λ/δ
λ = 500/2000/7500) spectrograph. In this paper, we investigate the capability of the Muztagh-Ata 1.93 m telescope in measuring time delays of strongly lensed quasars. We generate mock strongly lensed quasar systems and light curves with microlensing effects based on five known strongly lensed quasars, i.e., RX J1131-1231, HE 0435-1223, PG 1115+080, WFI 2033-4723 and SDSS 1206+4332. In particular, RX J1131-1231 is generated based on the lens modeling results of Suyu et al. Due to the lack of enough information, the other four systems are calculated by a simple analytical approximation. According to simulations, for RX J1131-like systems (wide variation in time delay between images) the TDSL measurement can be achieved with the precision about Δt = 0.5 day with four seasons campaign length and 1 day cadence. This accuracy is comparable to the up-coming TDCOSMO project. And it would be better when the campaign length keeps longer and with high cadence. As a result, the capability of the Muztagh-Ata 1.93 m telescope allows it to join the network of TDSL observatories. It will enrich the database for strongly lensed quasar observations and make more precise measurements of time delays, especially considering the unique coordinate of the site.
ELM sputter erosion modeling of a tungsten coated small angle slot divertor in DIII-D
Authors: Brooks J.N. , Sizyuk T. , Sinclair G. , Abrams T. , Hassanein A. 
Published: December 2022

Abstract
We modeled plasma edge localized mode (ELM) sputter erosion for a Small Angle Slot divertor with a tungsten coated region (SAS-VW), designed for experiments in the DIII-D tokamak, and proposed for use in future advanced tokamaks. The simulations use a free-streaming, 1000 eV, C+6 and D+1 ELM impingement model, with SOLPS-ITER, ITMC-DYN, and REDEP/WBC code packages for background plasma, material response, and erosion/redeposition respectively. The results show ELM’ing plasma gross and net tungsten erosion fluxes of the mixed-material C/W surface peaking at the slot entrance region, and an order of magnitude higher than for non-ELMs. The per-pulse erosion, however, remains low, of order 0.5 nm, due to expected moderate ELM frequencies and duration in DIII-D. The ELMs result in a ∼25x higher peak sputtered W current leaving the divertor slot region, towards the core plasma, compared to the ELM-free plasma case. The time-integrated escape current, however, may not significantly affect core plasma high-Z contamination concerns, for a 1% ELM duty factor, but may be an issue for higher frequency ELMs. In general, the modeling results appear favorable for effective testing of the SAS-VW divertor in DIII-D, and extrapolation to innovative divertor designs in future ITER-like and DEMO fusion devices.
The Differences of sensory quality in kimchi from Korea and Indonesia: A Systematic Review
Authors: Teiseran Anastasia Audrey Umriso , Cicilia  , Natalia Paula , Christian Vinnca Natalia , Miharti Yan , Rukmini Elisabeth 
Published: December 2022

AbstractKimchi is a traditional Korean fermented food made from mixed vegetables and unique ingredients. Kimchi is a functional food with a probiotic effect that gives consumers health benefits, especially on the intestines. This literature review aimed to determine the differences in sensory quality of kimchi products in South Korea and Indonesia. We performed a systematic literature review using search engines: Google Scholar, NCBI, Science Direct, Neliti, and Research Gate to search for articles. The number of articles we found for this systematic review is 21 articles. In conclusion, the sensory of Kimchi between Indonesia and Korea can be affected by five factors: (1) metabolic production of lactic acid bacteria, (2) food starter, including type of vegetables and other seafood, (3) salt and salting process, (4) spices, including capsaicinoids,gojugaru, and (5) Fermentation time. The taste of Kimchi from Indonesia is less spicy and less acidic compared to Korean Kimchi. Kimchi from Korea is spicier because Korean Kimchi containsgochugaruthat can affect the spiciness. Kimchi in Korea is sourer and has a softer texture because Korea has a longer fermentation time than Indonesia. The Kimchi produced in Indonesia is less acidic because the Indonesian salt concentration is higher, which affect the acidity of Kimchi and the texture is harder than Korean Kimchi.
Measurement of quality non-specific and specific-parameters of 70% ethanol extract and simplicia from cascara coffee robusta (Coffea canephora L.) and its potency as antioxidant.
Authors: Utami N F , Elya B , Hayun  , Kusmardi  
Published: December 2022

Abstract
Cascara coffee robusta (Coffea canephora L.) has been previously studied and has been reported to have biological activity with potential antibacterial and antioxidant effects. The ethanol extracts of cascara coffee robusta contained secondary metabolites: flavonoids, alkaloids, steroids, terpenoids and tannins. Measuring the quality of natural ingredients is an important means of maintaining the quality and safety of natural medicines. The purpose of the research was to measure the quality of non-specific and specific-parameters of extract and 70% ethanol and simplicia from cascara robusta coffee and evaluate its antioxidant activity. Material and Methods: Samples were soaking with ethanol 70% and evaluated for antioxidant activity using the DPPH method. Results: The results showed that the specific parameters have the same organoleptic properties as simplicia and a 70% ethanol extract of cascara coffee robusta are dark brown, characteristic odor, slightly bitter taste. Water soluble and ethanol soluble 70% ethanol extract of cascara has a total content of 51.98% ± 0.31 and 68.36% ± 1.74. Phytochemical screening results for 70% ethanol extract and simplicial of cascara coffee robusta include alkaloids, flavonoids, saponins, terpenoids, steroids, and tannins. Non-specific parameters of cascara coffee robusta simplicia; total water content of 3.26% ± 0.44; Total ash 4.91% ± 0.16; acid-insoluble ash 0.55% ± 0.33; <1.0 x 100 CFU / gr fungal and yeast contamination; <1.0 x 100 CFU / gr microbial contamination. Non-specific parameters of cascara coffee robusta extract; total water content of 3.55% ± 0.57; total ash of 6.15% ± 0.00; total acid-insoluble ash 0.23% ± 0.02; <1.0 x 10^0 CFU / gr fungal and yeast contamination; <1.0 x 10^0 CFU / gr microbial contamination. Ability the antioxidant activity was demonstrated by the IC50 values of simplicia and the extract, ie 55.14 ± 1.90 μg/mL simplicia and 57.40±0.29 μg/mL extract. Conclusions: Statistical tests show that there is no difference between the values of specific, non-specific parameters and their antioxidant capacity of simplicia and the extract, and all parameters follow standard procedures as a reference requirements. Showed that it meets.
Traceability system for lobsters supply chain: a review finding and method
Authors: Elfiana N , Sulaiman I , Yusriana  
Published: December 2022

AbstractThe traceability system is the ability to trace a product that was developed by a producer to meet consumers’ requirements on origin of its. In recent years, the result of traceability system research has increased significantly, mostly in the fisheries supply chain. At the first, research on traceability systems focused on fisheries products due to antibiotic contamination in the early 1990s. The objective of this paper is to obtain a mapping of traceability system research has done and to analyze its benefit of it for the future. In two decades, the development of this topic is very quick including the seafood supply chain. In this paper, the traceability system was mapped by three aspects, namely based on commodities, method and tracing level, and at the final step, we review the traceability of lobster commodity which is focused on the value chain that influences its quality. Future work of this research was analyzed as our contribution.