bluuebunny/crossref_metadata_2025_split huggingface dataset:
Oral side effects of COVID‐19 vaccines in 32 European countries: Analysis of EudraVigilance reports
Authors: Riad Abanoub , Schulz‐Weidner Nelly , Dziedzic Arkadiusz , Howaldt Hans‐Peter , Attia Sameh 
Published: May 2023

AbstractThe recent reports of oral side effects (SEs) following COVID‐19 vaccination warrant further investigation into their prevalence, severity, and aetiology. This study was conducted to synthesize the first‐ever population‐level evidence about oral SEs of COVID‐19 vaccines in Europe. The European Union Drug Regulating Authorities Pharmacovigilance (EudraVigilance) database was accessed in August 2022 to extract summary data of all potential oral SEs reported after COVID‐19 vaccination. The data were reported descriptively and cross‐tabulated to facilitate sub‐group analysis per vaccine type, sex, and age group. Dysgeusia was the most commonly reported oral SE (0.381 case per each 100 received reports), followed by oral paraesthesia (0.315%), ageusia (0.296%), lip swelling (0.243%), dry mouth (0.215%), oral hypoaesthesia (0.210%), swollen tongue (0.207%), and taste disorder (0.173%). Females had significantly (Sig. < 0.001) a higher prevalence of all most common (top 20) oral SEs, except for salivary hypersecretion, which was equally prevalent among females and males. The present study revealed a low prevalence of oral SEs, with taste‐related, other sensory and anaphylactic SEs being the most common SEs in Europe, similar to what was found earlier among the US population. Future studies should explore the potential risk factors of oral sensory and anaphylactic SEs to verify whether they are causally linked to COVID‐19 vaccines.
Application of aggregation behavior of nonionic surfactants to develop a smart detergent for washing fruits with emphasis on pesticide residues removal
Authors: Hordyjewicz‐Baran Zofia , Wasilewski Tomasz , Zarębska Magdalena , Seweryn Artur , Zajszły‐Turko Ewa , Stanek‐Wandzel Natalia , Chrobak Justyna 
Published: May 2023

AbstractModel smart detergents for fruit washing were designed. Their physicochemical and functional properties were determined, with particular emphasis on the efficiency of removing pesticide residues. The specific behavior of nonionic surfactants near the so‐called cloud point was used in the design of the new smart detergent. The high performance of detergents was related to the temperature‐dependent aggregation behavior of surfactants. Liquid chromatography coupled with mass spectrometry (LC–MS/MS) was used to evaluate the washing efficiency. Four types of pesticides (boscalid, acetamiprid, pyraclostrobin and pendimethalin) were applied to apples and then washed with designed detergents. Washing efficiency was evaluated based on the change in pesticide content on the apple surface. Compared to water, the model detergents were found to be more effective in removing pesticide residues, reaching values above 80%. The detergents were also evaluated for skin effects and revealed a low potential for skin irritation.
Oat β‐glucan alleviates muscle atrophy via promoting myotube formation and suppressing protein degradation
Authors: Zhang Jingjie , Zheng Mengjun , Zhou Linyue , Li Xinping , Yu Yonghui , Wang Jing , Sun Baoguo 
Published: May 2023

AbstractBACKGROUNDThe dangerous inducers of muscle atrophy are inflammatory reaction, oxidative stress, and cachexia, etc. β‐Glucan, an important food derived active ingredient, has been reported to exert anti‐inflammatory effects, however, its effects on regulating myoblast differentiation and protein degradation are unclear. This study is aimed to investigate the mechanism of oat β‐glucan on alleviating muscle atrophy.RESULTSThe results showed that oat β‐glucan treatment reversed tumor necrosis factor‐α (TNF‐α) induced abnormal myoblast differentiation and reduced muscle atrophy related MuRF‐1 and Atrogin‐1 protein expression. The similar phenomenon was observed after using MCC950 (NLRP3 specific inhibitor) or AS1842856 (FoxO1 specific inhibitor) to suppress NLRP3 and FoxO1 expression, respectively. Exposure to β‐glucan or AS1842856 also inhibited TNF‐α induced the activation of TLR4/NF‐κB pathway by inactivating FoxO1, and subsequently suppressed the expression of NLRP3.CONCLUSIONOur results indicate that oat β‐glucan exerts essential roles in promoting myoblast differentiation and alleviating muscle atrophy via inactivating FoxO1 and NLRP3 inflammasome signal pathway. © 2023 Society of Chemical Industry.
Enhanced depth of field of integral imaging display using bifocal microlens array fabricated by two‐step lithography
Authors: Wang Wenwen , Zhang Yongai , Wu Chaoxing , Yan Qun , Guo Tailiang , Zhou Xiongtu 
Published: May 2023

AbstractDue to the limitation of traditional microlens arrays (MLAs) in integral imaging display, the depth of field (DOF) is restricted in space and the center depth plane is difficult to extend in a large range. Here, we propose a microfabrication method based on bifocal MLAs to improve DOF. The bifocal MLAs for extended DOF were fabricated by using two‐step photolithography and thermal reflow. This method allows diverse microlenses of high to low numerical aperture to achieve high spatial resolution as well as accurate depth estimation. Microlenses of different focal lengths were simultaneously deposited on a substrate by repeated photolithography with multiple photomasks with alignment mark to define micro‐posts of different thicknesses. Hexagonally packaged bifocal MLAs clearly show the DOF extended from 0.004 to 4.908 mm for 57.6 μm in lens diameter, and their corresponding object distance ranges from 0.125 to 0.165 mm. Based on the proposed scheme, this method provides potential applications in integral imaging 3D display or light field display.
Development of a general separation strategy by countercurrent chromatography using sanshools from Zanthoxylum bungeanum oleoresin as a case study
Authors: Han Tian , Ling Tong , Fu Zhuo , Cao Xueli 
Published: May 2023

Three kinds of sanshools were separated from Zanthoxylum bungeanum oleoresin by high‐speed countercurrent chromatography. Sanshools are a series of amide compounds extracted from the Zanthoxylum bungeanum. Due to similar structures, polarities, and dissociation constants, it was challenging to select an appropriate solvent system for their complete separation by countercurrent chromatography. To address this challenge, a solvent‐system‐selection strategy was proposed to identify a relatively suitable solvent system. Additionally, a separation procedure incorporating multi‐elution modes selection was established to separate similar compounds in a logical order. Ultimately, a solvent system comprising n‐hexane:ethyl acetate:methanol:water in a ratio of 19:1:1:5.67 was selected. Three amide compounds with high purity were obtained through the use of recycling elution mode to improve separation resolution: hydroxy‐ε‐sanshool (8.4 mg; purity: 90.64%), hydroxy‐α‐sanshool (326.4 mg; purity: 98.96%), and hydroxy‐β‐sanshool (71.8 mg; purity: 98.26%) were obtained from 600 mg sanshool crude extract. The summarized solvent‐system‐selection strategy and separation procedure incorporating multi‐elution modes may instruct countercurrent chromatography users, particularly novices, seeking to separate compounds with highly similar chemical properties.
Olfactory Dysfunction and Balance Dysfunction are Associated with Increased Falls in Older Adults
Authors: Yesantharao Lekha V. , Vohra Varun , Cheng Michael , Simonsick Eleanor M. , Agrawal Yuri , du Lac Sascha , Rowan Nicholas R. 
Published: May 2023

ObjectiveThis study aims to characterize the association between impairments in olfaction and balance, both of which are mediated in part by the cerebellum, and how this relates to prospective incidence of falls in a cohort of aging adults.MethodsThe Health ABC study was queried to identify 296 participants with data on both olfaction (measured using the 12‐item Brief Smell Identification Test) and balance‐related function (measured using the Romberg test). The relationship between olfaction and balance was investigated using multivariable logistic regression. Predictors of performance on a standing balance assessment and predictors of falls were studied.ResultsOf 296 participants, 52.7% had isolated olfactory dysfunction, 7.4% had isolated balance dysfunction, and 5.7% had dual dysfunction. Severe olfactory dysfunction was associated with increased odds of balance dysfunction when compared to those without olfactory dysfunction, even when adjusting for age, gender, race, education, BMI, smoking, diabetes, depression, and dementia (OR = 4.1, 95% CI [1.5, 13.7], p = 0.011). Dual sensory dysfunction was associated with worse performance on a standing balance assessment (β = −22.8, 95% CI [−35.6, −10.1], p = 0.0005) and increased falls (β = 1.5, 95% CI [1.0, 2.3], p = 0.037).ConclusionThis study highlights a unique relationship between olfaction and balance, and how dual dysfunction is associated with increased falls. With substantial implications of falls on morbidity and mortality in older adults, this novel relationship between olfaction and balance emphasizes a potentially shared mechanism between olfactory dysfunction and increased fall risk in older adults; however, further study is required to explore the novel relationship of olfaction with balance and future falls.Level of Evidence3 Laryngoscope, 133:1964–1969, 2023
Chitosan‐Based Hydrogels for Infected Wound Treatment
Authors: Wang Xiaoyu , Song Rijian , Johnson Melissa , A Sigen , Shen Pingping , Zhang Nan , Lara‐Sáez Irene , Xu Qian , Wang Wenxin 
Published: May 2023

AbstractWound infections slow down the healing process and lead to complications such as septicemia, osteomyelitis, and even death. Although traditional methods relying on antibiotics are effective in controlling infection, they have led to the emergence of antibiotic‐resistant bacteria. Hydrogels with antimicrobial function become a viable option for reducing bacterial colonization and infection while also accelerating healing processes. Chitosan is extensively developed as antibacterial wound dressings due to its unique biochemical properties and inherent antibacterial activity. In this review, the recent research progress of chitosan‐based hydrogels for infected wound treatment, including the fabrication methods, antibacterial mechanisms, antibacterial performance, wound healing efficacy, etc., is summarized. A concise assessment of current limitations and future trends is presented.
The pain of payment: A review and research agenda
Authors: Reshadi Farnoush , Fitzgerald M. Paula 
Published: May 2023

AbstractPain of payment is the negative psychological affect consumers experience when they become cognizant that they have lost a certain amount of their financial resources (immediate pain) or when they become aware that they will or may lose a certain amount of their financial resources in the future (anticipated pain). Pain of payment plays a significant role in consumer decision making and has attracted substantial scholarly interest in recent years. In this article, we conduct a systematic literature review of the existing work on pain of payment. We advance theory in the field by proposing a new organizing framework that summarizes the antecedents, moderators, and consequences of pain of payment. Furthermore, we provide a formal definition of pain of payment that encompasses all facets of this construct. Subsequently, we identify knowledge gaps and outline research questions that could be explored to improve our understanding of this construct and advance consumer psychology.
Accessing care during the pandemic: A UK wide survey of people with rheumatoid arthritis and adult juvenile inflammatory arthritis during the COVID‐19 pandemic
Authors: Andev Rajinder Singh , Jacklin Clare , Bosworth Ailsa , Dubey Shirish 
Published: May 2023

AbstractCOVID‐19 drastically changed healthcare delivery models for rheumatology services. We sought to understand the impact of these changes for patients with Rheumatoid Arthritis (RA) and adult Juvenile Inflammatory Arthritis (AJIA) in established patients and those newly diagnosed during the pandemic.ResultsOf the 316 participants, a significant proportion regularly used analgesics (45.4%, n = 119), corticosteroids (17.9%, n = 47) and Non‐Steroidal Anti‐Inflammatory Drugs [(NSAIDs) (36.6%, n = 96)]. Two thirds of participants (66.5%, n = 210) did not know their Disease Activity Score‐28 (DAS28). Of the remaining third, moderate disease activity (12%, n = 38) was most reported. We found that 16.8% (n = 53) felt their condition was managed well during the pandemic. The remainder felt more negatively. For the newly diagnosed cohort, 34.5% (n = 10) delayed seeking GP help because of COVID‐19 concerns. Once assessed, a quarter (24.1%, n = 7) were referred to rheumatology after 4 or more consultations. We found 47% (n = 77) expressed positive opinions on remote consultations, whereas 36% (n = 59) had concerns. The lack of clinical examination (42.5%, n = 25) was flagged. Changing the dynamic from health worker to a patient centred approach was the most wished for improvement (20.3%, n = 64).ConclusionsMost participants did not know their disease activity status, which is of concern. With a push towards patient‐centred and patient‐led care, education and supported self‐management is critically important. There is high use of NSAIDs and corticosteroids. Pathways of care underwent change with subsequent delays in specialist assessment. The introduction of patient‐initiated follow‐up (PIFU) and virtual consultations further distances healthcare professionals from patients and could affect outcomes.
Interpenetrating shape memory polyimide‐polyaniline composites with electrical conductivity
Authors: Gao Hui , Li Jinrong , Kong Fangong , Wang Zhaojiang , Xu Feng 
Published: May 2023

AbstractShape memory polyimides (SMPI) with adjustable shape recovery temperatures have been paid much attention in both fundamental research and practical applications. However, the intrinsically electrical insulation of SMPIs limits their applications. In this article, the electrically conductive shape memory polyimide‐polyaniline (SMPI‐PANI) composite with interpenetrating networks was synthesized by in situ polycondensation. Compared with pure SMPI, the electrical resistivity of SMPI‐PANI composites reduced by about 12 orders of magnitude when the PANI content was 15 wt%. The addition of PANI had less influence on the glass transition temperature and storage modulus in glassy state. But the storage modulus of SMPI‐PANI composites in rubbery state was over 40 times higher than that of pure SMPI, indicating that SMPI‐PANI composites have higher stiffness during shape recovery. The SMPI‐PANI composites demonstrate excellent shape memory performance with shape fixation ratio higher than 97% and shape recovery ratio higher than 93%. The SMPI‐PANI composites also have good thermal stability with the effective decomposition temperatures higher than 150°C. The SMPI‐PANI composite in our work is a potential material for deployable aerospace structure.
Tailoring capture‐recapture methods to estimate registry‐based case counts based on error‐prone diagnostic signals
Authors: Ge Lin , Zhang Yuzi , Ward Kevin C. , Lash Timothy L. , Waller Lance A. , Lyles Robert H. 
Published: May 2023

SummarySurveillance research is of great importance for effective and efficient epidemiological monitoring of case counts and disease prevalence. Taking specific motivation from ongoing efforts to identify recurrent cases based on the Georgia Cancer Registry, we extend recently proposed “anchor stream” sampling design and estimation methodology. Our approach offers a more efficient and defensible alternative to traditional capture‐recapture (CRC) methods by leveraging a relatively small random sample of participants whose recurrence status is obtained through a principled application of medical records abstraction. This sample is combined with one or more existing signaling data streams, which may yield data based on arbitrarily non‐representative subsets of the full registry population. The key extension developed here accounts for the common problem of false positive or negative diagnostic signals from the existing data stream(s). In particular, we show that the design only requires documentation of positive signals in these non‐anchor surveillance streams, and permits valid estimation of the true case count based on an estimable positive predictive value (PPV) parameter. We borrow ideas from the multiple imputation paradigm to provide accompanying standard errors, and develop an adapted Bayesian credible interval approach that yields favorable frequentist coverage properties. We demonstrate the benefits of the proposed methods through simulation studies, and provide a data example targeting estimation of the breast cancer recurrence case count among Metro Atlanta area patients from the Georgia Cancer Registry‐based Cancer Recurrence Information and Surveillance Program (CRISP) database.
Synthesis of tetragonal SnO2 photocatalyst for Micro‐structural analysis and visible light driven Fenton‐like degradation of Methylene Blue
Authors: Banu Afroja , Barman Subhodeep , Sinha Biswajit , Sikdar Suranjan 
Published: May 2023

AbstractThe present study reports a simple co‐precipitation followed by solid state method for the synthesis of tetragonal SnO2 nanoparticles.The nanoparticles were characterized by XRD, FTIR, SEM, DLS, UV‐vis, and PL techniques to examine the structural properties, functional group, morphological and electronic properties. As prepared SnO2 NPs has been used for Fenton‐like degradation of Methylene blue(MB) in presence of solar light in aqueous solution.The structural analysis and Rietveld refinement revealed that the tetragonal SnO2 NPs have been well formed. The mean crystallite size of the synthesized nanoparticles was found to be 16.47 nm using the Scherrer formula.The Williamson‐Hall method determines strain throughout the crystal. The effect of various parameters such as catalyst dose, dye concentration, H2O2 concentration, pH and temperature was examined.The complete degradation of MB was obtained at pH=9. The results obtained from kinetics showed that degradation of MB dye follows pseudo‐first order rate with the rate constant k1 is 7.889×10−2 min−1. From Brunauer‐Emmet‐Teller (BET) surface analysis, we have determined the surface area and average pore size of SnO2 NPs. All parameters were measured by Brunauer‐Emmet‐Teller (BET) surface analysis with nitrogen adsorption‐desorption isotherm.The pore volume and pore diameter was calculated by BJH (Barrett‐Joyner‐Halenda) model.
Controlled Delivery of Amoxicillin and Rifampicin by Three‐Dimensional Polyvinyl alcohol/Bismuth Ferrite Scaffolds
Authors: Ilgar Sule , Ulag Songul , Sahin Ali , Gunduz Oguzhan , Ustundag Cem Bulent 
Published: May 2023

AbstractSkin is a protective barrier that can protect against environmental influences and renew itself. However, in some cases, this regenerative property is lost, and this causes delays in wound healing. Wound healing is a complex and long‐lasting phase. Any bacterial infection during the wound healing process delays wound healing. The therapeutic efficacy can be increased by using nanocarrier drug delivery systems to the target tissue with modern wound dressings. Controlled nano drug delivery systems increase the therapeutic efficacy in the treatment of diseases and provide a faster recovery process. In this study, amoxicillin (AMX) and rifampicin (RIF) were loaded into the bismuth ferrite (BFO) particles which were synthesized with the co‐precipitation method. Then, these drug‐loaded BFO particles (0.075 %) were added separately to 13 % polyvinyl alcohol (PVA) solution and the solutions were printed three‐dimensionally to obtain three dimensional scaffolds. With these designed scaffolds, it is aimed to reduce the risk of inflammation in wound tissues and increase therapeutic efficacy with controlled release. The SEM images proved that homogeneous pore distributions could be achieved with these combinations. The tensile test results showed that drug‐loaded BFO addition increased the mechanical strength of the 13 % PVA scaffold. The biocompatibility test results demonstrated that the highest viability values of the human adipose tissue‐derived mesenchymal stem cells were obtained for AMX‐added 13 % PVA scaffolds.
Artificial intelligence‐assisted point‐of‐care testing system for ultrafast and quantitative detection of drug‐resistant bacteria
Authors: Ding Yang , Chen Jingjie , Wu Qiong , Fang Bin , Ji Wenhui , Li Xin , Yu Changmin , Wang Xuchun , Cheng Xiamin , Yu Hai‐Dong , Hu Zhangjun , Uvdal Kajsa , Li Peng , Li Lin , Huang Wei 
Published: May 2023

AbstractAs one of the major causes of antimicrobial resistance, β‐lactamase develops rapidly among bacteria. Detection of β‐lactamase in an efficient and low‐cost point‐of‐care testing (POCT) way is urgently needed. However, due to the volatile environmental factors, the quantitative measurement of current POCT is often inaccurate. Herein, we demonstrate an artificial intelligence (AI)‐assisted mobile health system that consists of a paper‐based β‐lactamase fluorogenic probe analytical device and a smartphone‐based AI cloud. An ultrafast broad‐spectrum fluorogenic probe (B1) that could respond to β‐lactamase within 20 s was first synthesized, and the detection limit was determined to be 0.13 nmol/L. Meanwhile, a three‐dimensional microfluidic paper‐based analytical device was fabricated for integration of B1. Also, a smartphone‐based AI cloud was developed to correct errors automatically and output results intelligently. This smart system could calibrate the temperature and pH in the β‐lactamase level detection in complex samples and mice infected with various bacteria, which shows the problem‐solving ability in interdisciplinary research, and demonstrates potential clinical benefits.
Ligand‐Crosslinking Strategy for Efficient Quantum Dot Light‐Emitting Diodes via Thiol‐Ene Click Chemistry
Authors: Shin Seungki , Kang Kyungwan , Jang Hyunwoo , Gwak Namyoung , Kim Seongchan , Kim Tae Ann , Oh Nuri 
Published: May 2023

AbstractWhile solution‐processable colloidal quantum dots (QDs) offer cost‐effective and large‐scale manufacturing, they can be susceptible to subsequent solution processes, making continuous processing challenging. To enable complex and integrated device architectures, robust QD films with subsequent patterning are necessary. Here, we report a facile ligand‐crosslinking strategy based on thiol‐ene click chemistry. Thiol molecules added to QD films react with UV light to form radicals that crosslink with QD ligands containing carbon double bonds, enabling microscale photo‐patterning of QD films and enhancing their solvent resistance. This strategy can also be extended to other ligand‐capped nanocrystals. It is found that the swelling of QD films during the process of binding with the thiol molecules placed between the ligands contributes to the improvement of photoluminescence and electroluminescence properties. These results suggest that the thiol‐ene crosslinking modifies the optoelectronic properties and enables direct optical patterning, expanding the potential applications of QDs.