bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antimicrobial resistance patterns of WHO priority pathogens isolated in hospitalized patients in Japan: A tertiary centre observational study
Authors: Nisa Tania Tabassum , Nakatani Daisaku , Kaneko Fumie , Takeda Toshihiro , Nakata Ken 
Published: January 2023

Abstract
Background
After issuing the "Global action plan on antimicrobial resistance" in 2015, the World Health Organization (WHO) established a priority pathogens list for supporting research and development of novel antimicrobials. We conducted a comprehensive analysis of the WHO priority organisms in a Japanese tertiary hospital to apprehend the local AMR epidemiology
Methods
Data were obtained from electrical medical records in Osaka University Hospital between January 2010 and March 2021. The critical, high, and medium "priority pathogens list" categories of the WHO were used to compare results between the early (2010–2015) and late (2016–2021) phases.
Results
Out of 52,130 culture-positive specimens, a total of 9,872 (18.9%) contained WHO priority isolates. In comparison to early phases, late phases were likely to have higher rates of carbapenem resistance in Pseudomonas aeruginosa (15.7% vs 25.0%, P < 0.001), 3rd generation cephalosporin resistance in Escherichia coli (11.5% vs 17.8%, P < 0.001) as well as Klebsiella pneumoniae (1.6% vs 4.4%, P < 0.001), and ampicillin resistance in Haemophilus influenzae (2.4% vs 3.9%, P < 0.001). After 2015, however, the proportion of methicillin-resistant and vancomycin-intermediate Staphylococcus aureus was low. In this study, in-hospital mortality was comparable among patients with resistance to the three WHO priority pathogen types: critical (5.9%), high (3.9%), and medium (3.8%), and no significant change was observed between two phases in each category. However, significant interactions for in-hospital mortality were observed in subgroup analyses between “critical priority” AMR and the presence of comorbid conditions, such as chronic kidney disease or diabetes mellitus.
Conclusions
To implement better antimicrobial stewardship policies and practices, local priority pathogens and "high-risk" patients for in-hospital death need to be acknowledged and evaluated periodically.
Azathioprine Hypersenitivity: a Sweet-like Syndrome
Authors: Sivanandam Lokesh Koumar , Razul Benazir Begum , Martinez Ernesto Calderon , Garikapati Sushmitha , Sanker Vivek , Siddiq Abdelmonem 
Published: January 2023

Abstract
Introduction: Azathioprine is a purine analog used to treat autoimmune diseases and steroid refractory chronic diseases. Azathioprine hypersensitivity can present occasionally within weeks of initial therapy as Sweet-like Syndrome.
Case Summary: A 35 year old woman with Systemic Lupus Erythematosus (SLE) presented to the emergency department with complaints of generalized maculopapular rash, facial swelling and bilateral lower extremity edema of 4 days duration and two day history of constitutional symptoms like fever and nausea within two weeks of beginning of Azathioprine therapy to treat existing Lupus Nephritis (⅔).
Reason for the Report: Extensive skin signs include Erythema nodosum, small vessel vasculitis, acute widespread exanthematous pustulosis, sweet syndrome, and nonspecific dermatosis can be seen in patients with azathioprine hypersensitivity syndrome. It is known that the drug's imidazole component interacts with particular proteins to produce haptens, which further trigger Type 3 hypersensitivity reactions.
Outcome: Our case demonstrates the very fast onset of Azathioprine-induced Sweet-like Syndrome that happens after taking the offending medication. After ruling out viral and autoimmune reasons, this diagnosis can be made using routine laboratory tests and the results of a skin biopsy. The use of corticosteroids coupled with the discontinuation of azathioprine led to the complete disappearance of symptoms.
Construction and Validation of the Predictive Model for Gallbladder Cancer Liver Metastasis Patients: A SEER-based Study
Authors: Zhang Woods , Chen Zhitian , Sa Benzhong 
Published: January 2023

Abstract
Background
The purpose of this present research was to construct a nomograph model to predict prognosis in gallbladder cancer liver metastasis (GCLM) patients so as to provide a basis for clinical decision-making.
Methods
We surveyed patients diagnosed with gallbladder cancer liver metastasis (GCLM) in the Surveillance Epidemiology and the End Results database (SEER) between 2010 and 2019. They were randomized 6:4 into a training set and a validation set. In the training set, statistically meaningful prognostic factors were determined using univariate and multivariate Cox regression analyses, and an individualized nomogram prediction model was generated. The prediction model was evaluated by C-index and calibration curves from the training set and the validation set.
Results
727 confirmed cases were enrolled in the research, 426 in the training set and 301 in the validation set. Factors including bone-metastasis, surgery, chemotherapy and radiotherapy were independent prognostic factors for cancer specific survival (CSS) rates and were employed in the construction of the nomogram prediction model. The C-index for the training set and validation set were 0.685 and 0.709, respectively. Calibration curves indicated that the cancer specific survival (CSS) rates of the nomograph prediction model were consistent with the actual prognosis at 6-months-CSS, 1-year-CSS and 2-years-CSS in both the training set and validation set.
Conclusions
We have successfully constructed a nomogram prediction model that can predict cancer specific survival (CSS) rates in patients with gallbladder cancer liver metastasis (GCLM). This prediction model can help patients in counseling and guide clinicians in treatment decisions.
Platelet closure time in the evaluation of efficacy of CAR-T cell therapy in relapsed/refractory multiple myeloma
Authors: Ma Ruixue , Liu Yang , Zhang Qi , Chen Huimin , Zhang Qianqian , Guo Wentong , Qiao Jianlin , Qi Kunming , Shen Guifang , Sun Cai , Song Xuguang , Cao Jiang , Cheng Hai , Zhu Feng , Yan Zhiling , Sang Wei , Li Depeng , Sun Haiying , Zheng Junnian , Li Zhenyu , Xu Kailin , Chen Wei 
Published: January 2023

Abstract
Purpose
In recent years, many studies of platelet function in multiple myeloma (MM) patients have been reported. However, the role of platelet function in relapse/refractory (R/R) MM after chimeric antigen receptor T (CAR-T) cell therapy remains to be clarified.
Methods
In this study, we investigated platelet closure time (PCT) in the evaluation of efficacy of CAR-T cell therapy in patients with R/R MM, clinical data of 50 patients were retrospectively analyzed. Collagen/adenosine diphosphate (CADP) and Collagen/Epinephrine (CEPI)-induced PCT of peripheral blood were detected by platelet function analyzer-200, respectively, with 20 healthy individuals as control.
Results
After the approach of CAR-T cell therapy, CADP PCT and CEPI PCT decreased significantly when compared with those before treatment: (67.22, 95% CI 46.91–87.53, P < 0.01) and (77.46, 95% CI 59.43–95.50, P < 0.01). CADP PCT was positively correlated with TT (r = 0.305, P = 0.047), ISS stage (r = 0.389, P = 0.005) and cytokine release syndrome (CRS) stage (r = 0.328, P = 0.020), whereas negatively associated with λ-type light chain (r = − 0.399, P = 0.014) and IgM (r = − 0.355, P = 0.017). In addition, patients who achieved >PR had a shorter PCT compared with those ≤ PR. Moreover, the PCT of patients with grade 3–5 CRS was considerably longer than grade 0–2 CRS after treatment.
Conclusion
PCT could be defined as a potential indicator in the evaluation of efficacy of CAR-T cell therapy.
information system for data collection for community-based rehabilitation programs
Authors: Darmawan Wawan , Nur Firdaus 
Published: January 2023

Program Rehabilitasi Bersumberdaya Masyarakat adalah program pembinaan wilayah dalam hal pencegahan kedisabilitasan/kecacatan, deteksi dan rehabilitasi/habilitasi segala aspek kehidupan untuk pemberdayaan Penyandang Disabilitas, keluarga dan masyarakat. Pada tugas skripsi ini penulis mengangkat masalah, bagaimana membuat sistem informasi pendataan dan dapat di implementasikan pada organisasi Pusat Studi dan Informasi Kedisabilitasan Indonesia.
Untuk mendukung perancangan system informasi ini penulis mengumpulkan informasi melalui observasi, studi kepustakaan, dan dokumentasi. Program ini dibuat dengan Bahasa pemograman PHP dan MySql sebagai basis data. Sistem ini menggunakan metode Sosfware Development Life Cycle (SDLC) dengan menggunakan salah satu modelnya yaitu model Waterfall dengan tahapan dalam perancangan ini meliputi analisis kebutuhan perangkat lunak dan perangkat keras, perancangan sistem, pengkodean, pengujian, dan pemeliharaan program yang dibuat.
Sistem Informasi yang dirancang ini dapat membantu organisasi Pusat Studi dan Informasi Kecacatan Indonesia dalam mengelola database, sehingga memudahkan dalam proses evaluasi dan monitoring program Rehabiliasi Bersumberdaya Masyarakat.
Kata kunci : Pemberdayaan, Disabilitas
IMPLEMENTASI PIVOT TABLE UNTUK PENILAIAN BERBASIS CPMK
Authors: Wijana Katon , Oslan Yetli , Kristanto Harianto 
Published: January 2023

Akreditasi merupakan kegiatan penilaian sesuai dengan kriteria yang telah ditetapkan berdasarkan Standar Nasional Pendidikan Tinggi (SNDikti). Akreditasi dilakukan untuk menentukan kelayakan Program Studi dan Perguruan Tinggi atas dasar kriteria yang mengacu pada SNDikti, sebagaimana diamanatkan oleh Undang-undang Nomor 12 Tahun 2012 tentang Pendidikan Tinggi Pasal 55 Ayat (1) dan Ayat (2). Standar kompetensi lulusan merupakan kriteria minimal tentang kualifikasi kemampuan lulusan yang mencakup sikap, pengetahuan, dan keterampilan yang dinyatakan dalam rumusan capaian pembelajaran lulusan(CPL). Capaian pembelajaran lulusan (CPL) masih bersifat umum, harus dijabarkan ke dalam bentuk yang lebih spesifik yaitu ketercapaian capaian pembelajaran mata kuliah (CPMK), setiap mata kuliah wajib mempunyai CPMK yang mengacu pada CPL.
Dalam pemberian nilai pada CPMK, banyaknya nilai yang dimasukkan untuk tiap mata kuliah berbeda-beda, oleh karenanya nilai-nilai CPMK tiap mata kuliah akan disimpan dalam bentuk baris-baris rekaman nilai. Untuk merangkum nilai-nilai CPMK dalam bentuk baris ini dapat dibuat pivot table dalam bentuk kolom-kolom, namun dalam sebuah universitas, tiap program studi mempunyai ragam dan jumlah CPMK yang berbeda-beda, oleh karenanya tidak bisa dibuat suatu pivot table yang spesifik untuk ragam dan jumlah CPMK tertentu, sehingga harus dibuat suatu pivot table yang bersifat fleksibel baik ragam maupun jumlahnya.
Pada penelitian ini akan dibuat suatu program aplikasi yang dapat dipergunakan untuk mengukur ketercapaian pembelajaran lulusan (CPL) berbasis capaian pembelajaran matakuliah CPMK memakai pivot table generator sehingga dapat bersifat fleksibel baik dari sisi ragam CPL maupun banyaknya CPL program studi.
Kata Kunci— Pivot table, generator, capaian pembelajaran lulusan
Penerapan Simhash dan Hamming distance dalam Deteksi kemiripan Teks Berita
Authors: Anggelina Mayesti , Dwi Krisnawati Lucia Dwi Krisnawati , Sebastian Danny 
Published: January 2023

Daur Ulang Text didefinisikan sebagai pemanfaatan sumber tulisan yang ada untuk penulisan sebuah teks baru. Persentase penggunaan ulang teks dari sumber sebelumnya sangatlah bervariasi. Jika prosentase penggunaan tersebut tinggi dan berasal dari sebuah sumber, maka teks yang baru menjadi teks duplikat atau hampir duplikat dengan teks sumbernya. Meskipun beberapa genre teks bisa diterima, keberadaan teks duplikat dan hampir dupilkat ini menyebabkan ketidak-efisienan penyimpanan dan pencarian. Untuk itu diperlukan sebuah system deteksi kemiripan teks yang akan mengidentifikasi teks mana saja yang dupilkat dan hampir duplikat. Untuk itu, penelitian ini berfokus pada deteksi kemiripan teks dengan mengaplikasikan algoritma Simhash. Algoritma ini digunakan untuk menghasilkan fingerprint dokumen yang berfungsi sebagai fitur dokumen yang digunakan sebagai dasar pembanding tingkat kemiripan teks. Kemiripan sebuah teks terhadap teks lainnya diukur dengan menggunakan jarak Hamming. Dalam ekperimen yang difokuskan pada dokumen duplikat dan hampir duplikat, tingkat Recall dokumen cukup tinggi yakni 80%. Ini berarti bahwa sistem yang dikembangkan mampu menemenukan pasangan dokumen duplikat dengan baik.
Variability of Volatile Oils Composition, Tannins, and Phenols from Campomanesia adamantium (CAMBESS.) O. Berg
Authors: Sá Stone de , Fiuza Tatiana de Sousa , Borges Leonardo Luiz , Cunha Luiz Carlos da , Oliveira Neto Jerônimo Raimundo de , Paula José Realino de 
Published: January 2023

Campomanesia adamantium (Myrtaceae), known as "guabiroba-do-campo", is a native Cerrado shrub popularly used as anti-inflammatory, antidiarrheal, urinary tract antiseptics. The aims of this study were evaluate the seasonal variability of total phenols and tannins and chemical compounds of the volatile oils of C. adamantium leaves in a period of 12 months. The leaves and flowers were collected in Bela Vista, Goiás, Brazil. The volatile oils were obtained by hydrodistillation in a Clevenger apparatus and analyzed by GC/MS. The determination of total phenols and tannins was performed by the method of Hagerman and Butler. The major compounds of the leaves oils were γ-elemene, limonene, italicene epoxide, β-funebrene, bicyclogermacrene, linalool, and those of flower oil were sabinene, limonene, linalool, tricyclene and methyl salicylate. The total phenols content ranged from 3.75% to 9.56% and tannins content from 2.25% to 4.84%. It was concluded that the best period for collecting the leaves with the highest index phenols and tannins is the low rainfall. This work represents the first description of the seasonal variability of the essential oils, tannins and total phenols of C. adamantium collected in Bela Vista.
Neuroeducación e Inclusividad en el Marco de la Comunicación y el Turismo
Authors: Barrientos-Báez Almudena , Caldevilla-Domínguez David , Parra-López Eduardo 
Published: January 2023

El Libro Blanco del Diseño para Todos en la Universidad (2006), marcó un antes y un después para favorecer cambios sustanciales en los planes de estudio de las diferentes universidades españolas. Las instituciones públicas apoyan explícitamente la corriente de pensamiento de la inclusividad y el respeto hacia todos desarrollando un trabajo que ayuda a los estudiantes y profesores a colaborar en el proyecto de Capacitación universitaria en el diseño para todas las personas. Se basa en la colaboración entre diferentes administraciones públicas con empresas del sector privado.
Los graduados en Turismo durante el ejercicio de su profesión interactúan con personas que pueden tener dificultades de movilidad o patologías que pueden dificultarles disfrutar del destino turístico. Por lo tanto, la educación y la comunicación se convierten en el núcleo de esta investigación. A partir de la aplicación de una metodología de análisis bibliográfico y documentos oficiales, se analiza la situación actual con el objetivo de fomentar la enseñanza con estilos de aprendizaje activos que motivan al alumno a capacitarse para aumentar y facilitar la inclusión y el disfrute de todos en el sector turístico, tanto por viajeros como por los propios trabajadores. En este sentido, herramientas innovadoras tales como la neuroeducación deben ser consideradas como instrumentos válidos.
Mission in covid/post-covid times Drawing inspiration from pope Francis
Authors: Catalano Roberto 
Published: January 2023

In Bergoglio’s thinking, to build on fraternity in order to create a culture of encounter and justice means to move together towards unity, which helps to be committed “to allow people to serve as a body despite differences of viewpoint, physical separation and human ego”.[1] This attitude and these commitments will prevent us from falling into uniformity while respecting the values and richness of plurality. In fact, in today’s world, while we are more and more interconnected we experience a deep sense of division, especially at the social and economic level. Our societies and communities are more and more fragmented and this creates dangerous polarizations, as it is seen in politics and social life. Fraternity will help to foster dialogue at all levels and this will enable people “to generate a shared horizon toward which we can all move forward together”.[2] This does not mean, in Pope Francis’ understanding, denying tensions and differences. It rather calls for the engagement of everyone and all communities to work for a wider unity where all differences remain and coexist while working together. This reading of the present reality can help us react to the pandemic as a people, as a whole humanity with its differences and riches. But we need the courage “to restore an ethics of fraternity and solidarity, regenerating the bonds of trust and belonging. For what it saves is not an idea but an encounter.”

[1] Ibid., p. 68.
[2] Ibid., p. 76.
Blessed Are Those Who Do Not Know the Future of the Church. A Plea for Negative Ecclesiology
Authors: Jos Moons 
Published: January 2023

What will the future of the church look like? What type of mission should the church commit herself to? Rather than elaborating one more answer to these important questions, I have pleaded for negative ecclesiology and ‘the grace of self-doubt’. This is not to replace the answers that are given, but to safeguard sufficient openness in these answers. By abstaining from certitude, the church may more easily hear what the Spirit is saying to the churches beyond our own, human and therefore narrow minded understandings. My brief discussions on the Trinity, Ignatian spiritual direction and synodality were meant to illustrate that ‘wise ignorance’ and openness to surprises are present in some other dimensions of the Christian faith and theology and may, therefore, be safely adopted in reflections on the future of the church.
A great fruit of negative ecclesiology is that it allows for change, that is, for a new understanding of God and therefore a new understanding of the church. Because the Apostles allowed for uncertainty, they could accept that God’s grace did not require circumcision and Jewish purity regulations – a crucial revolution in the early Christian church. Similarly, during the Second Vatican Council the bishops did not insist on using the same words, and were therefore able to embrace another, more pastoral style of magisterial teaching.
In the same way, negative ecclesiology can help the church – its leadership as much as lay faithful – to be open to new perspectives on church and on mission. It may help to confront the painful truth that in the West the omnipresence of the church belongs to a past era and that in the church’s role in society is becoming a marginal one. It may help the faithful and church leadership to embrace the task of bringing the number of church buildings more in line with the church’s current position in society – that is, to abolish a significant number of churches. Finally, it may help to reconceive the church’s prophetic voice into a more dialogical and humble voice, which testifies rather than criticizes, and that is willing to learn as much as to teach.
The Use of Patient-Generated Health Data From Consumer-Grade Mobile Devices in Clinical Workflows: Protocol for a Systematic Review
Authors: Guardado Medina Sharon , Isomursu Minna 
Published: January 2023

Background
With the rapid advancement of mobile technology, the scope of mobile health (mHealth) has expanded to include consumer-grade devices such as smartphones and wearable sensors. These solutions have typically been used for fitness purposes; however, due to their ubiquitous capabilities for data collection, they have the potential to bridge information gaps and supplement data from clinical visits. Patient-generated health data (PGHD) can be derived from mHealth solutions and be used by health care professionals (HCPs) as complementary tools in the care process, yet their integration into clinical workflows presents a myriad of challenges. PGHD might be a new and unfamiliar source of information for most HCPs, and the majority of mHealth solutions have not been designed to be used by HCPs as active reviewers. As mHealth solutions become more available and attractive to patients, HCPs may see an increase in the influx of data and related inquiries from their patients. This mismatch in expectations can result in disruptions to clinical workflows and negatively impact patient-clinician relationships. For PGHD to be integrated into clinical workflows, its use should be proven beneficial for both patients and HCPs. However, so far, only limited research has been done on the concrete experiences of HCPs as active reviewers of PGHD from consumer-grade mobile devices.

Objective
We aimed to systematically guide the review of existing literature to identify what types of PGHD from consumer-grade mobile devices are currently being used by HCPs as complementary tools in the care process.

Methods
The PRISMA-P (Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols) 2015 was followed for the design of the search, selection, and data synthesis processes. Electronic searches will be done on PubMed, ACM Digital Library, IEEE Xplore, and Scopus.

Results
Preliminary searches have been conducted, and previous related systematic and scoping reviews have been found and evaluated. The review is expected to be completed in February 2023.

Conclusions
This protocol will guide the review of existing literature on the use of PGHD produced by consumer-grade mobile devices. Although there have been previous reviews related to this topic, our proposed approach seeks to understand the specific opinions and experiences of different types of HCPs who are already using PGHD in their clinical practice and the motives for deeming these data useful and worth reviewing. Depending on the studies that will be included, there may be an opportunity to provide a wider understanding of what types of HCPs trust PGHD, despite the possible challenges that its use might convey, potentially contributing with the knowledge to support the design strategies of mHealth tools that could be integrated into clinical workflows.

International Registered Report Identifier (IRRID)
PRR1-10.2196/39389
Gravity wave drag parameterizations for Earth's atmosphere
Authors: Kruse Christopher G , Richter Jadwiga H , Alexander M. Joan , Bacmeister Julio T , Heale Christopher , Wei Junhong 
Published: January 2023

Atmospheric gravity waves (GWs), or buoyancy waves, transport momentum
and energy through Earth’s atmosphere. GWs are important at nearly all
levels of the atmosphere, though, the momentum they transport is
particularly important in general circulation of the middle and upper
atmosphere. Primary sources of atmospheric GWs are flow over mountains,
moist convection, and imbalances in jet/frontal systems. Secondary GWs
can also be generated as a result of dissipation of a primary GWs.
Gravity waves typically have horizontal wavelengths of 10’s to 100’s of
kilometers, though, they can have scales of 1’s to 1000’s of kilometers
as well. Current effective resolutions of climate models, and even
numerical weather prediction models, do not resolve significant portions
of the momentum- and energy-flux-carrying GW spectrum, and so
parameterizations are necessary to represent under- and unresolved GWs
in most current models. Here, an overview of GWs generated by
orography, convection, jet/front systems, primary wave breaking, and
secondary wave generation is provided. The basic theory of GW
generation, propagation, and dissipation relevant to parameterization is
presented. Conventionally used GW parameterizations are then reviewed.
Lastly, we describe uncertainties and parameter tuning in current
parameterizations and discuss known processes that are currently
missing.