bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predictors associated with critical care need and in-hospital mortality among children with laboratory-confirmed COVID-19 infection in a high HIV infection burden region
Authors: Byamungu Liliane N. , Nachega Jean B. , Pillay Ashendri , Katoto Patrick D. M. C. , Jeena Prakash , Zurba Lindsay , Masekela Refiloe 
Published: September 2023

IntroductionDespite the extra mortality associated with COVID-19 death globally, there is scant data on COVID-19-related paediatric mortality in Sub-Saharan Africa. We assessed predictors of critical care needs and hospital mortality in South African children with laboratory-confirmed SARS-CoV-2 infection in region with high HIV infection burden.MethodsWe conducted a secondary multicentre analysis of the AFREhealth cohort (a multinational, multicentre cohort of paediatric COVID-19 clinical outcomes across six African countries) of children admitted to the Inkosi Albert Luthuli, a quaternary hospital in KwaZulu-Natal, South Africa, with confirmed RT-PCR between March 2020 and December 2020. We constructed multivariable logistic regression to explore factors associated with the need for critical care (high care/ intensive care hospitalisation or oxygen requirement) and cox-proportional hazards models to further assess factors independently associated with in-hospital death.ResultsOf the 82 children with PCR-confirmed SARS-CoV-2 infection (mean ± SD age: 4.2 ± 4.4 years), 35(42.7%) were younger than one year, 52(63%) were female and 59(71%) had a pre-existing medical condition. Thirty-seven (45.2%) children required critical care (median (IQR) duration: 7.5 (0.5–13.5) days) and 14(17%) died. Independent factors associated with need for critical care were being younger than 1 year (aPR: 3.02, 95%CI: 1.05–8.66; p = 0.04), having more than one comorbidity (aPR: 2.47, 95%CI: 1.32–4.61; p = 0.004), seizure (aPR: 2.39, 95%CI: 1.56–3.68; p &lt; 0.001) and impaired renal function. Additionally, independent predictors of in-hospital mortality were exposure to HIV infection (aHR: 6.8, 95%CI:1.54–31.71; p = 0.01), requiring invasive ventilation (aHR: 3.59, 95%CI: 1.01–12.16, p = 0.048) and increase blood urea nitrogen (aHR: 1.06, 95%CI: 1.01–1.11; p = 0.017). However, children were less likely to die from COVID-19 if they were primarily admitted to quaternary unit (aHR: 0.23, 95%CI: 0.1–0.86, p = 0.029).ConclusionWe found a relatively high hospital death rate among children with confirmed COVID-19. During COVID-19 waves, a timely referral system and rapid identification of children at risk for critical care needs and death, such as those less than one year and those with comorbidities, could minimize excess mortality, particularly in high HIV-infection burden countries.
Cost-effectiveness analysis of transarterial chemoembolization combined with lenvatinib as the first-line treatment for advanced hepatocellular carcinoma
Authors: He Ying , Lin Wangchun , Cai Zhongjie , Huang Yufan , You Maojin , Lei Meisheng , Chen Ruijia 
Published: September 2023

Purpose: Results from the LAUNCH trial suggest transarterial chemoembolization (TACE) in combination with lenvatinib is significantly more effective than lenvatinib as a first-line treatment option for advanced hepatocellular carcinoma (HCC). However, the cost of TACE is substantial. This study compares the cost-effectiveness of TACE in combination with lenvatinib (TACE-LEN) with that of lenvatinib alone as the first-line treatment for advanced HCC from the perspective of the Chinese healthcare system.Methods: Markov models of different health states were constructed to simulate first-line treatment, disease progression, and survival in patients with advanced HCC. Clinical efficacy was obtained from the LAUNCH trial. The cost of drugs was sourced from national tender prices, and the treatment cost of weight-decreased was obtained from the Fujian Provincial Bureau of Prices. Other costs and utility values were based on the published literature. Total costs, life years (LYs), quality-adjusted life years (QALYs), and incremental cost-effectiveness ratios (ICERs) comprised the model output. One-way and probabilistic sensitivity analyses were performed to validate model robustness and subgroup analyses were also conducted.Results: Analysis of the model showed that compared to lenvatinib, TACE-LEN improved effectiveness by 1.60 QALYs at a total cost increase of $48,874.69, with an ICER value of $30,482.13/QALY. A one-way sensitivity analysis found that the progression-free survival utility value per year had the greatest impact on the model. A probabilistic sensitivity analysis showed that TACE-LEN had a 97.9% probability of being cost-effective as the first-line treatment option for advanced HCC compared to lenvatinib when the willingness-to-pay (WTP) value was $38,201/QALY (three times the Chinese GDP per capita in 2022). Subgroup analysis showed that all subgroups of patients preferred TACE-LEN. However, when the WTP threshold was below $30,300/QALY, TACE-LEN is no longer cost-effective.Conclusion: Our study found TACE-LEN to be a cost-effective treatment option for patients with advanced HCC compared to lenvatinib from a Chinese healthcare system perspective, but not so in low-income provinces in China.
UPLC-Q–TOF–MS, network analysis, and molecular docking to investigate the effect and active ingredients of tea-seed oil against bacterial pathogens
Authors: Duan Yan , Zhao Li-Juan , Zhou Yan-Hui , Zhou Qi-Zhi , Fang Ai-Qing , Huang Yu-Ting , Ma Yuan , Wang Zhi , Lu Yu-Ting , Dai Yu-Ping , Li Shun-Xiang , Li Juan 
Published: September 2023

Object: This research intended to probe the antibacterial effect and pharmacodynamic substances of Tea-Seed Oil (TSO) through the use of ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF/MS) analysis, network analysis, and molecular docking.Methods: The major chemical components in the methanol-extracted fractions of TSO were subjected to UPLC-Q-TOF-MS. Network pharmacology and molecular docking techniques were integrated to investigate the core components, targets, and potential mechanisms of action through which the TSO exert their antibacterial properties. To evaluate the inhibitory effects, the minimum inhibitory concentration and diameter of the bacteriostatic circle were calculated for the potential active ingredients and their equal ratios of combinatorial components (ERCC) against Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, and Candida albicans. Moreover, the quantification of the active constituents within TSO was achieved through the utilization of high-performance liquid chromatography (HPLC).Results: The methanol-extracted fractions contained a total of 47 chemical components, predominantly consisting of unsaturated fatty acids and phenolic compounds. The network pharmacology analysis and molecular docking analysis revealed that various components, including gallocatechin, gallic acid, epigallocatechin, theophylline, chlorogenic acid, puerarin, and phlorizin, have the ability to interact with critical core targets such as serine/threonine protein kinase 1 (AKT1), epidermal growth factor receptor (EGFR), a monoclonal antibody to mitogen-activated protein kinase 14 (MAPK14), HSP90AA1, and estrogen receptor 1 (ESR1). Furthermore, these components can modulate the phosphatidylinositol-3-kinase protein kinase B (PI3K-AKT), estrogen, MAPK and interleukin 17 (IL-17) signaling pathways, hereby exerting antibacterial effects. In vitro validation trials have found that seven components, namely gallocatechin, gallic acid, epigallocatechin, theophylline, chlorogenic acid, puerarin, and phloretin, displayed substantial inhibitory effects on E. coli, S. aureus, P. aeruginosa, and C. albicans, and are typically present in tea oil, with a total content ranging from 15.87∼24.91 μg·g−1.Conclusion: The outcomes of this investigation possess the possibility to expand our knowledge base concerning the utilization of TSO, furnish a theoretical framework for the exploration of antibacterial drugs and cosmetics derived from inherently occurring TSO, and establish a robust groundwork for the advancement and implementations of TOS products within clinical settings.
Heterogeneity characterization of hepatocellular carcinoma based on the sensitivity to 5-fluorouracil and development of a prognostic regression model
Authors: Gu Xinyu , Li Shuang , Ma Xiao , Huang Di , Li Penghui 
Published: September 2023

Background: 5-Fluorouracil (5-FU) is a widely used chemotherapeutic drug in clinical cancer treatment, including hepatocellular carcinoma (HCC). A correct understanding of the mechanisms leading to a low or lack of sensitivity of HCC to 5-FU-based treatment is a key element in the current personalized medical treatment.Methods: Weighted gene co-expression network analysis (WGCNA) was used to analyze the expression profiles of the cancer cell line from GDSC2 to identify 5-FU-related modules and hub genes. According to hub genes, HCC was classified and the machine learning model was developed by ConsensusClusterPlus and five different machine learning algorithms. Furthermore, we performed quantitative reverse transcription-polymerase chain reaction (qRT-PCR) analysis on the genes in our model.Results: A total of 19 modules of the cancer cell line were divided by WGCNA, and the most negative correlation with 5-FU was the midnight blue module, from which 45 hub genes were identified. HCC was divided into three subgroups (C1, C2, and C3) with significant overall survival (OS) differences. OS of C1 was the shortest, which was characterized by a high clinical grade and later T stage and stage. OS of C3 was the longest. OS of C2 was between the two subtypes, and its immune infiltration was the lowest. Five out of 45 hub genes, namely, TOMM40L, SNRPA, ILF3, CPSF6, and NUP205, were filtered to develop a risk regression model as an independent prognostic indicator for HCC. The qRT-PCR results showed that TOMM40L, SNRPA, ILF3, CPSF6, and NUP205 were remarkably highly expressed in hepatocellular carcinoma.Conclusion: The HCC classification based on the sensitivity to 5-FU was in line with the prognostic differences observed in HCC and most of the genomic variation, immune infiltration, and heterogeneity of pathological pathways. The regression model related to 5-FU sensitivity may be of significance in individualized prognostic monitoring of HCC.
Influence of motor imagery training on hip abductor muscle strength and bilateral transfer effect
Authors: Alenezi Majid Manawer , Hayes Amy , Lawrence Gavin P. , Kubis Hans-Peter 
Published: September 2023

Motor imagery training could be an important treatment of reduced muscle function in patients and injured athletes. In this study, we investigated the efficacy of imagery training on maximal force production in a larger muscle group (hip abductors) and potential bilateral transfer effects. Healthy participants (n = 77) took part in two experimental studies using two imagery protocols (∼30 min/day, 5 days/week for 2 weeks) compared either with no practice (study 1), or with isometric exercise training (study 2). Maximal hip abduction isometric torque, electromyography amplitudes (trained and untrained limbs), handgrip strength, right shoulder abduction (strength and electromyography), and imagery capability were measured before and after the intervention. Post intervention, motor imagery groups of both studies exhibited significant increase in hip abductors strength (∼8%, trained side) and improved imagery capability. Further results showed that imagery training induced bilateral transfer effects on muscle strength and electromyography amplitude of hip abductors. Motor imagery training was effective in creating functional improvements in limb muscles of trained and untrained sides.
Sex-related differences in the associations between diurnal cortisol pattern and social and emotional loneliness in older adults
Authors: Díaz-Mardomingo María del Carmen , Utrera Lucía , Baliyan Shishir , García-Herranz Sara , Suárez-Falcón Juan Carlos , Rodríguez-Fernández Raquel , Sampedro-Piquero Patricia , Valencia Azucena , Venero César 
Published: September 2023

IntroductionLoneliness is a distressful feeling that can affect mental and physical health, particularly among older adults. Cortisol, the primary hormone of the Hypothalamic-Pituitary-Adrenal axis (HPA-axis), may act as a biological transducer through which loneliness affects health. While most previous studies have evaluated the association between loneliness, as a unidimensional construct, and diurnal cortisol pattern, no research has examined this relationship discriminating between social and emotional loneliness in older adults. As sex differences in the negative mental health outcomes of loneliness have been reported, we also investigated whether diurnal cortisol indices and loneliness associations occur in a sex-specific manner.MethodsWe analyzed the diurnal cortisol- pattern in 142 community-dwelling, non-depressed, Caucasian older adults (55,6% female) aged 60-90. Social and emotional (family and romantic) loneliness scores were assessed using the Spanish version of the Social and Emotional Loneliness Scale for Adults (SELSA). Five salivary cortisol samples were used to capture key features of the diurnal cortisol pattern, including: awakening and bedtime cortisol levels, awakening response (CAR), post-awakening cortisol output (post-awakening cortisol [i.e., the area under the curve with reference to the ground: AUCG]), total diurnal cortisol release (AUCG), and diurnal cortisol slope (DCS).ResultsAfter controlling for sociodemographic variables, the hierarchical linear multiple regression analyses revealed that in male older adults, higher scores on social and family loneliness were associated with elevated awakening cortisol levels, total diurnal cortisol output, and a steeper diurnal cortisol slope (DCS). However, these associations were not observed in female older adults. In addition, feelings of romantic loneliness were positively associated with bedtime cortisol levels and AUCG in older males. Multilevel growth curve modeling showed that experiencing more social and emotional loneliness predicted higher diurnal cortisol output throughout the day in older male adults.DiscussionThe presence of sex differences in the relationship between cortisol indices and loneliness among older adults holds particular significance for diagnostic and screening procedures. Combining loneliness scales as screening tools with diurnal cortisol measures has the potential to be an effective and cost-efficient approach in identifying higher-risk individuals at early stages.
Problematic social media use and mental health risks among first-year Chinese undergraduates: a three-wave longitudinal study
Authors: Zhou Wanqi , Yan Zhihao , Yang Zeyang , Hussain Zaheer 
Published: September 2023

IntroductionThe association between social media use and mental health risks has been widely investigated over the past two decades with many cross-sectional studies reporting that problematic social media use (PSMU) is associated with higher mental health risk such as anxiety and depression. The present study examined the relationship between PSMU severity and mental health risks (depression, anxiety, stress, and loneliness) using a three-wave longitudinal design.MethodsA total of 685 first-year Chinese undergraduate students (Mean age = 19.12 years, SD = 0.92) completed surveys at three times points with intervals of 3 to 4 months. Results revealed that PSMU was positively correlated with all the mental health risk variables over the three time points.ResultsThe prevalence of PSMU increased over the three research waves. Cross-lagged models identified bi-directional relationships between PSMU and mental health risks, while such links were not consistent between different mental health risk variables and can change over different research intervals.DiscussionThis study indicates that PSMU and mental health risks could predict each other in a vicious loop, but the differences between specific mental health risks and the research context (e.g., different term times and experiences in university) should not be ignored. Further research attention should be paid to the prevalence of PSMU and mental health conditions among Chinese first-year undergraduates who appear to have difficulties in adapting to university life.
Psychosocial assessment tools for use before transplantation are predictive of post-operative psychosocial and health behavior outcomes: a narrative review of the literature
Authors: Thode Sorin , Perry Keith , Cyr Samuel , Ducharme Anique , Puissant David , Brouillette Judith 
Published: September 2023

IntroductionIn end-stage diseases, transplantation may be necessary. The limited number of donors led to the development of several pre-transplant psychosocial assessment tools. We summarized the predictive value of these tools before solid-organ transplantation.MethodsThe PRISMA search strategy and the MEDLINE database were used to review the literature. From 1,050 records, we found thirteen studies using four different scales (Millon Behavioral Health Inventory [MBHI], Psychosocial Assessment of Transplant Candidates [PACT], Stanford Integrated Psychosocial Assessment for Transplantation [SIPAT], and Transplant Evaluation Rating Scale [TERS]).ResultsTERS and MBHI were associated with the highest number of positive studies concerning pre-transplant scores and primary outcomes. Psychosocial scales predict in a systematic way psychosocial and health behavioural outcomes, but generated mixed results for mortality and rejection.DiscussionThis narrative review underlines the need for multidisciplinary evaluation and well-conducted clinical trials to assist transplant teams in utilizing psychosocial evaluation effectively during evaluation of candidates.
Landscape, agrobiodiversity, and local knowledge in the protected area “Quebrada de los Cuervos y Sierras del Yerbal,” Uruguay
Authors: Puppo María , Gianotti Camila , Calvete Alejandra , Leal Alejandra , Rivas Mercedes 
Published: September 2023

IntroductionAgrobiodiversity and local knowledge are fundamental components in the domestication and structuring of rural landscapes. In a context of threats to agroecosystems resulting from changes in production systems and rural–urban migration processes, the conservation and valorization of agrobiodiversity is a pressing challenge. “Quebrada de los Cuervos and Sierras del Yerbal” is a protected landscape in Uruguay where a rural community of approximately 30 families with a long-standing tradition resides.MethodsThe research aimed at identifying current and abandoned (taperas) domestic contexts, and the plant genetic resources found in the area, categorizing their uses and management practices through interviews and participant observation.Results and discussionEthnographic research revealed 185 species (121 exotic, 64 native) with diverse growth habits, 10 categories of uses, and 11 categories for management practices. The differences found between houses and taperas revealed that the abandonment of activities in rural areas is a relevant factor in the loss of agrobiodiversity. Among the 185 species, a notable group of plant genetic resources of high cultural significance is recognized due to their consensus of use, frequency of management practices, and number of uses. These include introduced fruit trees (peach, citrus, and fig) and native fruit trees (guayabo del país, pitanga, and arazá), vegetable landraces, native trees with multiple uses, yerba mate, and medicinal species such as Aristolochia fimbriata. For domestic contexts, a model of spatial distribution of agrobiodiversity is proposed, cultivated spaces where the plant genetic resources are located in home gardens and small plots, managed spaces where the resources are found in the surroundings of houses, and promoted and intervened wild spaces where the species are used from natural grasslands and wild environments. The obtained information reaffirms the need to conserve this biocultural landscape, placing agrobiodiversity and local knowledge as a focal point in the protected area. The management plan must be formulated with active participation from the rural community, aiming for valorization through integration into agroecological production chains, among other possibilities.
ANALISIS FAKTOR PENYEBAB KETERLAMBATAN DAN PERBANDINGAN PEKERJAAN PEMASANGAN BEKISTING ALUMINIUM – BEKISTING KONVENSIONAL DITINJAU DARI SEGI WAKTU, BIAYA, DAN MUTU
Authors: Yogiswara Reza , Andreas Azaria , Trisno Lestari Rini 
Published: September 2023

Pandemi Covid-19 yang terjadi pada tahun 2020 memberikan pengaruh yang sangat besar di segala aspek kehidupan masyarakat di indonesia, termasuk industri konstruksi. Hal ini memberikan dampak yang signifikan terhadap pekerjaan konstruksi. Pada kenyataannya di lapangan masih sering terjadi keterlambatan dan penyimpangan kualitas konstruksi pada tahap pelaksanaan proyek, hal ini bukan hanya disebabkan oleh faktor alam yaitu gangguan cuaca seperti curah hujan yang sangat tinggi yang mempengaruhi intensitas kerja, selain itu juga disebabkan oleh material yang tidak sesuai Dalam penelitian kali ini tujuan yang ingin dicapai yaitu: Mengetahui faktor-faktor penyebab keterlambatan; Pemilihan metode bekisting yang tepat untuk Proyek Pembangunan Apartemen dan Hotel Oyama Plaza Sunter Jakarta Utara; Mengetahui perbandingan waktu, mutu dan biaya pekerjaan bekisting dengan metode alform dan metode konvensional. Penelitian ini menggunakan metode penelitian kuantitatif deskriptif, dengan cara mengumpul data melalui kuisioer kemudian dilakukan perhitungan untuk mengetahui hubungan antara variabel yang di ujikan, serta untuk mengetahui perbandingan mutu waktu dan biaya. Terlalu banyak merebuah pesanan oleh owner menjadi penyebab utama keterlambatan, Lambat mengambil keptusan menjadi penyebab no. 2, sementara perubahan material dan spesifikasi selama konstruksi menjadi penyebab no. 3. Dalam hal watu pelaksanaan metode bekisting alumunium lebih cepat 33 hari dan harga yang lebih mahal Rp. 213.599.232,00 tetapi proyek bisa mengemat biaya-biaya lain seperti biaya umum, biaya alat, dan biaya lain-lain selama 1 bulan. Sedangkan dalam hal mutu bekisting alumunium lebih tinggi kualitasnya dan lebih bersih
ANALISIS PENGARUH PENERAPAN ISO 9001: 2015 TERHADAP KINERJA WAKTU PELAKSANAAN
Authors: Prenata Putra Chandra , Dofir Akhmad 
Published: September 2023

Penerapan sistem manajemen mutu berdasarkan ISO 9001:2015 merupakan nilai tambah bagi perusahaan, dalam rangka meminimalkan produk yang sesuai dengan standar yang telah ditetapkan dan meminimalisasikan pekerjaan ulang. Pada umumnya proyek konstruksi mengalami keterlambatan, terutama pada tahap awal pelaksanaan. Proyek Pembangunan Indoor Multifunction Stadium Dalam Rangka Kejuaraan Dunia Bola Basket Tahun 2023 Penelitian ini untuk mengetahui pengaruh dari penerapan ISO:2015 terhadap kinerja waktu yang berdeviasi positif., berdasarkan hasil pembahasan dikategorikan sangat baik dengan persentase sebesar 89,978%. dari variabel dominan yaitu variabel Peningkatan dengan nilai rata-rata 90,933%, dengan menggunakan uji korelasi 0,956 nilai korelasi berada diantara 0,90<KK<1,00 yang berarti kekuatan hubungan yang sangat tinggi atau kuat sekali. Pada uji regresi linier sederhana secara signifikan menunujukan hubungan positif, dimana bila peningkatan 1% akan meningkatkan pula kinerja waktu pelaksanaan sebesar 0,341.Dari hasil uji determinasi antara pengaruh penerapan ISO 9001:2015 terhadap kinerja waktu pelaksanaan sebesar 91,4% , nilai tersebut menunjukan bahwa Kinerja waktu pelaksanaan proyek dipengaruhi oleh penerapan ISO 9001:2015,