bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inscribing security: The case of Zelensky’s selfies
Authors: Markussen Håvard Rustad 
Published: August 2023

Abstract‘Visual turn’ scholarship in International Relations (IR) acknowledges the importance of new information and communication technology for the production and circulation of images but lacks sustained engagement with the technologies themselves and how they interact with humans in the visual production of security. This article brings the visual turn into conversation with Science and Technology Studies (STS) and mobilises Latour and Woolgar’s notion of inscription to show how the production of visual artefacts and their security effects are conditioned by human/device interaction. It advances the argument that the representational force of a visual artefact is dependent not only on the content and quality of the artefact itself, but also on the specific human/device relations that condition its production. To illustrate this, the article theorises the smartphone as an inscription device and the selfie as an inscription practice and analyses the case of Zelensky’s selfie videos from the first few days after Russia’s invasion of Ukraine. Selfies inscribe meaning to security issues by mobilising the photographic affordances of indexicality, composition, and reflection in unique ways. Specifically, they focus images on the communicative acts of their producers and play on the relationship between human and device to invoke feelings of immediacy, authenticity, and intimacy.
The epidemiology of CHD in Malta
Authors: Grech Victor , Gatt Miriam , Calleja Neville 
Published: August 2023

AbstractBackground:CHD refers to structural cardiac abnormalities which comprise the commonest group of congenital malformations. Malta is a small island in the central Mediterranean with excellent diagnostic and therapeutic facilities. It is unique in the European population as termination of pregnancy is illegal. This study was carried out to ascertain patterns in CHD prevalence in comparison with EUROCAT data (European Surveillance of Congenital Anomalies).Methods:Anonymised data were obtained from the EUROCAT website for 1993–2020.Results:There were a total of 22,833,032 births from all EUROCAT Registries, of which 121,697 were from Malta. The prevalence rate for Malta CHD was 32.38/10,000 births (at the higher end of the range). Malta had a significant excess of commoner, comparatively non-severe CHDs. For most of the severe lesions analysed rates reported were higher than EUROCAT average, however, apart from Ebstein’s anomaly, they all fell within the ranges reported from the different registries.Discussion:Wide variations in reported CHD prevalence are known, and the Malta rates may be higher for milder defects due to quicker pickup prior to spontaneous resolution. There may also be a higher pickup of milder forms of more severe conditions. For the more severe conditions, lack of termination may be the explanation. These factors may result in the higher neonatal mortality observed in Malta.
Occupational Injuries and Illnesses among Paramedicine Clinicians: Analyses of US Department of Labor Data (2010 – 2020)
Authors: Maguire Brian J. , Al Amiry Ala’a , O’Neill Barbara J. 
Published: August 2023

AbstractObjective:Paramedicine clinicians (PCs) in the United States (US) respond to 40 million calls for assistance every year. Their fatality rates are high and their rates of nonfatal injuries are higher than other emergency services personnel, and much higher than the average rate for all US workers. The objectives of this paper are to: describe current occupational injuries among PCs; determine changes in risks over time; and calculate differences in risks compared to other occupational groups.Methods:This retrospective open cohort study of nonfatal injuries among PCs used 2010 through 2020 data from the US Department of Labor (DOL), Bureau of Labor Statistics; some data were unavailable for some years. The rates and relative risks (RRs) of injuries were calculated and compared against those of registered nurses (RNs), fire fighters (FFs), and all US workers.Results:The annual average number of injuries was: 4,234 over-exertion and bodily reaction (eg, motion-related injuries); 3,935 sprains, strains, and tears; 2,000 back injuries; 580 transportation-related injuries; and over 400 violence-related injuries. In this cohort, women had an injury rate that was 50% higher than for men. In 2020, the overall rate of injuries among PCs was more than four-times higher, and the rate of back injuries more than seven-times higher than the national average for all US workers. The rate of violence-related injury was approximately six-times higher for PCs compared to all US workers, seven-times higher than the rate for FFs, and 60% higher than for RNs. The clinicians had a rate of transportation injuries that was 3.6-times higher than the national average for all workers and 2.3-times higher than for FFs. Their overall rate of cases varied between 290 per 10,000 workers in 2018 and 546 per 10,000 workers in 2022.Conclusions:Paramedicine clinicians are a critical component of the health, disaster, emergency services, and public health infrastructures, but they have risks that are different than other professionals.This analysis provides greater insight into the injuries and risks for these clinicians. The findings reveal the critical need for support for Emergency Medical Services (EMS)-specific research to develop evidence-based risk-reduction interventions. These risk-reduction efforts will require an enhanced data system that accurately and reliably tracks and identifies injuries and illnesses among PCs.
Food for thought or food for emotions? An analysis of marketing strategies in television food advertising seen by children in Colombia
Authors: Velasquez Alcides , Parra Maria Fernanda , Mora-Plazas Mercedes , Gómez Luis Fernando , Taillie Lindsey Smith , Dillman Carpentier Francesca Renee 
Published: August 2023

AbstractObjective:To establish the relationship between the marketing strategies and nutritional quality of foods and beverages promoted in television food advertisements (TV ads) seen by Colombian child audiences overall and based on child gender and socio-economic strata (SES).Design:A quantitative content analysis of marketing appeals was combined with nutritional data of the food products advertised and matched with TV audience ratings data for each food and beverage ads for Colombian children between 4 and 11 years.Setting:All beverages and foods TV ads cable or over-the-air channels in Colombia in 2017.Participants:N/A.Results:Compared with rational appeals (e.g. freshness, health or nutrition messages), emotional appeals (referencing or depicting human senses or emotions, e.g. using cartoons to suggest fun) were more frequently used in the TV ads most viewed by Colombian children. Female children and children in lower SES tended to be more exposed to emotional appeals in TV ads than their male or higher SES counterparts. Furthermore, TV ads using more emotional appeals tended to be for products high in problematic nutrients.Conclusion:The findings of this study highlight the need to implement statutory measures to reduce the deleterious effect of food marketing on children.
Strong Haze‐Black Carbon‐Climate Connections Observed Across Northern and Eastern China
Authors: Zhang Yuxuan , Wu Nana , Wang Jiaping , Huang Xin , Wang Zilin , Liu Tengyu , Geng Guannan , Qi Ximeng , Nie Wei , Chi Xuguang , Zhang Qiang , Ding Aijun 
Published: August 2023

AbstractRadiative absorption of black carbon (BC) is of great importance in air quality and climate change. Simultaneous mitigation of haze pollution and climate warming requires an in‐depth understanding of haze‐BC‐climate connections based on direct observations. We simultaneously performed measurements in the North China Plain (NCP) and the Yangtze River Delta (YRD) during the winter of 2018–2019, when cross‐regional haze transport frequently occurred. We found that BC particles exhibited a thick coating thickness (100–120 nm) under haze pollution conditions in the NCP and were then transported to the YRD with regional haze development. BC particles in the downwind region showed a bimodal distribution of core‐size‐resolved aging degree, which can be used to separate and quantify local and regional BC. The results showed that the regional haze transport from the NCP brought 1–3 μg m−3 BC into the YRD. These regional BC particles exhibited ∼1.6 times stronger absorption efficiency than locally emitted BC. The direct radiative effects of BC in the downwind region were estimated to be enhanced by ∼2 times when regional haze pollution was transported from the NCP to the YRD. The amplification of BC's climate effect during regional haze pollution was attributed to the increases in both the mass concentrations and light absorption efficiency of BC, which were responsible for 40%–50% and 50%–60%, respectively. Our work identified strong haze‐BC‐climate connections across the NCP and YRD and highlighted the importance of BC in the effects of haze pollution on regional climate.
Stratosphere‐Troposphere Coupling of Extreme Stratospheric Wave Activity in CMIP6 Models
Authors: Ding Xiuyuan , Chen Gang , Ma Weiming 
Published: August 2023

AbstractExtreme stratospheric wave activity has been suggested to be connected to surface temperature anomalies, but some key processes are not well understood. Using observations, we show that the stratospheric events featuring weaker‐than‐normal wave activity are associated with increased North American (NA) cold extreme risks before and near the event onset, accompanied by less frequent atmospheric river (AR) events on the west coast of the United States. Strong stratospheric wave events, on the other hand, exhibit a tropospheric weather regime transition. They are preceded by NA warm anomalies and increased AR frequency over the west coast, followed by increased risks of NA cold extremes and north‐shifted ARs over the Atlantic. Moreover, these links between the stratosphere and troposphere are attributed to the vertical structure of wave coupling. Weak wave events show a wave structure of westward tilt with increasing altitudes, while strong wave events feature a shift from westward tilt to eastward tilt during their life cycle. This wave phase shift indicates vertical wave coupling and likely regional planetary wave reflection. Further examinations of CMIP6 models show that models with a degraded representation of stratospheric wave structure exhibit biases in the troposphere during strong wave events. Specifically, models with a stratospheric ridge weaker than the reanalysis exhibit a weaker tropospheric signal. Our findings suggest that the vertical coupling of extreme stratospheric wave activity should be evaluated in the model representation of stratosphere‐troposphere coupling.
Description of Martian Convective Vortices Observed by InSight and Implications for Vertical Vortex Structure and Subsurface Physical Properties
Authors: Onodera Keisuke , Nishida Kiwamu , Kawamura Taichi , Murdoch Naomi , Drilleau Mélanie , Otsuka Ryoji , Lorenz Ralph , Horleston Anna , Widmer‐Schnidrig Rudolf , Schimmel Martin , Rodriguez Sebastien , Carrasco Sebastián , Tanaka Satoshi , Perrin Clement , Lognonné Philippe , Spiga Aymeric , Banfield Don , Panning Mark , Banerdt William Bruce 
Published: August 2023

AbstractConvective vortices (whirlwinds) and dust devils (dust‐loaded vortices) are one of the most common phenomena on Mars. They reflect the local thermodynamical structure of the atmosphere and are the driving force of the dust cycle. Additionally, they cause an elastic ground deformation, which is useful for retrieving the subsurface rigidity. Therefore, investigating convective vortices with the right instrumentation can lead to a better understanding of the Martian atmospheric structures as well as the subsurface physical properties. In this study, we quantitatively characterized the convective vortices detected by NASA's InSight (∼13,000 events) using meteorological (e.g., pressure, wind speed, temperature) and seismic data. The evaluated parameters, such as the signal‐to‐noise ratio, event duration, asymmetricity of pressure drop profiles, and cross‐correlation between seismic and pressure signals, are compiled as a catalog. Using these parameters, we investigated (a) the vortex structure and (b) the subsurface physical properties. Regarding the first topic, we tried to illustrate the vertical vortex structure and its link to the shape of the pressure profiles by combining the asymmetrical features seen in the observed pressure drops and the terrestrial observations of dust devils. Our results indicate that most of the vortices move with the wall tilted in the advection direction. Concerning the second topic, selecting the highly correlated events between pressure perturbation and ground response, we estimated the subsurface rigidity at the InSight landing site down to 100 m depth. Our results indicate that the subsurface structure can be modeled with two layers having a transition at 5–15 m depth.
Novel insights into the pathogenesis of follicular lymphoma by molecular profiling of localized and systemic disease forms
Authors: Kalmbach Sabrina , Grau Michael , Zapukhlyak Myroslav , Leich Ellen , Jurinovic Vindi , Hoster Eva , Staiger Annette M. , Kurz Katrin S. , Weigert Oliver , Gaitzsch Erik , Passerini Verena , Engelhard Marianne , Herfarth Klaus , Beiske Klaus , Micci Francesca , Möller Peter , Bernd Heinz-Wolfram , Feller Alfred C. , Klapper Wolfram , Stein Harald , Hansmann Martin-Leo , Hartmann Sylvia , Dreyling Martin , Holte Harald , Lenz Georg , Rosenwald Andreas , Ott German , Horn Heike ,   German Lymphoma Alliance (GLA)
Published: August 2023

AbstractKnowledge on the pathogenesis of FL is mainly based on data derived from advanced/systemic stages of FL (sFL) and only small cohorts of localized FL (lFL) have been characterized intensively so far. Comprehensive analysis with profiling of somatic copy number alterations (SCNA) and whole exome sequencing (WES) was performed in 147 lFL and 122 sFL. Putative targets were analyzed for gene and protein expression. Overall, lFL and sFL, as well as BCL2 translocation-positive (BCL2+) and –negative (BCL2−) FL showed overlapping features in SCNA and mutational profiles. Significant differences between lFL and sFL, however, were detected for SCNA frequencies, e.g., in 18q-gains (14% lFL vs. 36% sFL; p = 0.0003). Although rare in lFL, gains in 18q21 were associated with inferior progression-free survival (PFS). The mutational landscape of lFL and sFL included typical genetic lesions. However, ARID1A mutations were significantly more often detected in sFL (29%) compared to lFL (6%, p = 0.0001). In BCL2 + FL mutations in KMT2D, BCL2, ABL2, IGLL5 and ARID1A were enriched, while STAT6 mutations more frequently occurred in BCL2- FL. Although the landscape of lFL and sFL showed overlapping features, molecular profiling revealed novel insights and identified gains in 18q21 as prognostic marker in lFL.
NvPrdm14d-expressing neural progenitor cells contribute to non-ectodermal neurogenesis in Nematostella vectensis
Authors: Lemaître Quentin I. B. , Bartsch Natascha , Kouzel Ian U. , Busengdal Henriette , Richards Gemma Sian , Steinmetz Patrick R. H. , Rentzsch Fabian 
Published: August 2023

AbstractNeurogenesis has been studied extensively in the ectoderm, from which most animals generate the majority of their neurons. Neurogenesis from non-ectodermal tissue is, in contrast, poorly understood. Here we use the cnidarian Nematostella vectensis as a model to provide new insights into the molecular regulation of non-ectodermal neurogenesis. We show that the transcription factor NvPrdm14d is expressed in a subpopulation of NvSoxB(2)-expressing endodermal progenitor cells and their NvPOU4-expressing progeny. Using a new transgenic reporter line, we show that NvPrdm14d-expressing cells give rise to neurons in the body wall and in close vicinity of the longitudinal retractor muscles. RNA-sequencing of NvPrdm14d::GFP-expressing cells and gene knockdown experiments provide candidate genes for the development and function of these neurons. Together, the identification of a population of endoderm-specific neural progenitor cells and of previously undescribed putative motoneurons in Nematostella provide new insights into the regulation of non-ectodermal neurogenesis.
DeSUMOylation of a Verticillium dahliae enolase facilitates virulence by derepressing the expression of the effector VdSCP8
Authors: Wu Xue-Ming , Zhang Bo-Sen , Zhao Yun-Long , Wu Hua-Wei , Gao Feng , Zhang Jie , Zhao Jian-Hua , Guo Hui-Shan 
Published: August 2023

AbstractThe soil-borne fungus Verticillium dahliae, the most notorious plant pathogen of the Verticillium genus, causes vascular wilts in a wide variety of economically important crops. The molecular mechanism of V. dahliae pathogenesis remains largely elusive. Here, we identify a small ubiquitin-like modifier (SUMO)-specific protease (VdUlpB) from V. dahliae, and find that VdUlpB facilitates V. dahliae virulence by deconjugating SUMO from V. dahliae enolase (VdEno). We identify five lysine residues (K96, K254, K259, K313 and K434) that mediate VdEno SUMOylation, and SUMOylated VdEno preferentially localized in nucleus where it functions as a transcription repressor to inhibit the expression of an effector VdSCP8. Importantly, VdUlpB mediates deSUMOylation of VdEno facilitates its cytoplasmic distribution, which allows it to function as a glycolytic enzyme. Our study reveals a sophisticated pathogenic mechanism of VdUlpB-mediated enolase deSUMOylation, which fortifies glycolytic pathway for growth and contributes to V. dahliae virulence through derepressing the expression of an effector.
Extravillous trophoblast cell lineage development is associated with active remodeling of the chromatin landscape
Authors: Varberg Kaela M. , Dominguez Esteban M. , Koseva Boryana , Varberg Joseph M. , McNally Ross P. , Moreno-Irusta Ayelen , Wesley Emily R. , Iqbal Khursheed , Cheung Warren A. , Schwendinger-Schreck Carl , Smail Craig , Okae Hiroaki , Arima Takahiro , Lydic Michael , Holoch Kristin , Marsh Courtney , Soares Michael J. , Grundberg Elin 
Published: August 2023

AbstractThe extravillous trophoblast cell lineage is a key feature of placentation and successful pregnancy. Knowledge of transcriptional regulation driving extravillous trophoblast cell development is limited. Here, we map the transcriptome and epigenome landscape as well as chromatin interactions of human trophoblast stem cells and their transition into extravillous trophoblast cells. We show that integrating chromatin accessibility, long-range chromatin interactions, transcriptomic, and transcription factor binding motif enrichment enables identification of transcription factors and regulatory mechanisms critical for extravillous trophoblast cell development. We elucidate functional roles for TFAP2C, SNAI1, and EPAS1 in the regulation of extravillous trophoblast cell development. EPAS1 is identified as an upstream regulator of key extravillous trophoblast cell transcription factors, including ASCL2 and SNAI1 and together with its target genes, is linked to pregnancy loss and birth weight. Collectively, we reveal activation of a dynamic regulatory network and provide a framework for understanding extravillous trophoblast cell specification in trophoblast cell lineage development and human placentation.
Indian Ocean glacial deoxygenation and respired carbon accumulation during mid-late Quaternary ice ages
Authors: Chang Liao , Hoogakker Babette A. A. , Heslop David , Zhao Xiang , Roberts Andrew P. , De Deckker Patrick , Xue Pengfei , Pei Zhaowen , Zeng Fan , Huang Rong , Huang Baoqi , Wang Shishun , Berndt Thomas A. , Leng Melanie , Stuut Jan-Berend W. , Harrison Richard J. 
Published: August 2023

AbstractReconstructions of ocean oxygenation are critical for understanding the role of respired carbon storage in regulating atmospheric CO2. Independent sediment redox proxies are essential to assess such reconstructions. Here, we present a long magnetofossil record from the eastern Indian Ocean in which we observe coeval magnetic hardening and enrichment of larger, more elongated, and less oxidized magnetofossils during glacials compared to interglacials over the last ~900 ka. Our multi-proxy records of redox-sensitive magnetofossils, trace element concentrations, and benthic foraminiferal Δδ13C consistently suggest a recurrence of lower O2 in the glacial Indian Ocean over the last 21 marine isotope stages, as has been reported for the Atlantic and Pacific across the last glaciation. Consistent multi-proxy documentation of this repeated oxygen decline strongly supports the hypothesis that increased Indian Ocean glacial carbon storage played a significant role in atmospheric CO2 cycling and climate change over recent glacial/interglacial timescales.
Applied machine learning as a driver for polymeric biomaterials design
Authors: McDonald Samantha M. , Augustine Emily K. , Lanners Quinn , Rudin Cynthia , Catherine Brinson L. , Becker Matthew L. 
Published: August 2023

AbstractPolymers are ubiquitous to almost every aspect of modern society and their use in medical products is similarly pervasive. Despite this, the diversity in commercial polymers used in medicine is stunningly low. Considerable time and resources have been extended over the years towards the development of new polymeric biomaterials which address unmet needs left by the current generation of medical-grade polymers. Machine learning (ML) presents an unprecedented opportunity in this field to bypass the need for trial-and-error synthesis, thus reducing the time and resources invested into new discoveries critical for advancing medical treatments. Current efforts pioneering applied ML in polymer design have employed combinatorial and high throughput experimental design to address data availability concerns. However, the lack of available and standardized characterization of parameters relevant to medicine, including degradation time and biocompatibility, represents a nearly insurmountable obstacle to ML-aided design of biomaterials. Herein, we identify a gap at the intersection of applied ML and biomedical polymer design, highlight current works at this junction more broadly and provide an outlook on challenges and future directions.
Photoredox cobalt-catalyzed regio-, diastereo- and enantioselective propargylation of aldehydes via propargyl radicals
Authors: Wang Lei , Lin Chuiyi , Chong Qinglei , Zhang Zhihan , Meng Fanke 
Published: August 2023

AbstractCatalytic enantioselective introduction of a propargyl group constitutes one of the most important carbon–carbon forming reactions, as it is versatile to be transformed into diverse functional groups and frequently used in the synthesis of natural products and biologically active molecules. Stereoconvergent transformations of racemic propargyl precursors to a single enantiomer of products via propargyl radicals represent a powerful strategy and provide new reactivity. However, only few Cu- or Ni-catalyzed protocols have been developed with limited reaction modes. Herein, a photoredox/cobalt-catalyzed regio-, diastereo- and enantioselective propargyl addition to aldehydes via propargyl radicals is presented, enabling construction of a broad scope of homopropargyl alcohols that are otherwise difficult to access in high efficiency and stereoselectivity from racemic propargyl carbonates. Mechanistic studies and DFT calculations provided evidence for the involvement of propargyl radicals, the origin of the stereoconvergent process and the stereochemical models.