bluuebunny/crossref_metadata_2025_split huggingface dataset:
Is mushroom polysaccharide extract a better fat replacer than dried mushroom powder for food applications?
Authors: See Toh Cheryl Jie Yi , Bi Xinyan , Lee Hui Wen , Yeo Michelle Ting Yun , Henry Christiani Jeyakumar 
Published: February 2023

Introductionβ-glucans found in the cell walls of mushrooms can be a beneficial food additive in replacing fat in commercial food products.MethodsFour commonly consumed mushroom species in Singapore, i.e., Pleurotus ostreatus spp., Lentinus edodes, Agaricus bisporus, and Flammulina velutipes were profiled for the β-glucan content in the lyophilized form and ultrasonicated assisted extracted form. Both forms were added into chicken patties, which were characterized for the moisture, cooking loss, texture, color, and chemically analyzed for the protein, crude fat, and fatty acid profiles with gas chromatography mass spectrometry (GC-MS).Results and discussionPleurotus Ostreatus spp. had the highest β-glucan of 29.8 ± 0.7 g/100 g in the pure powder form and 15.9 ± 0.3 g/100 g from the extract. Crude fat in 100% fat substituted patties was lowest in Flammulina velutipes extract enriched patties and least in A. bisporus pure powder patties. Additionally, fat replacement with A. bisporus extract and powder forms resulted in the highest polyunsaturated fatty acid profile of 49.6 ± 1.9 mg/100 g patty and 79.9 ± 4.5 mg/100 g patty, respectively. Chicken patties with added mushroom extract were notable in retaining moisture, cooking yield and its structure. Fat substitution with mushroom powder was also conducted, satisfactory results indicated a possibility as a better fat replacer that is easily processed and an efficient alternative to β-glucan extract. With increasing demand for low fat foods with acceptable organoleptic properties, our study demonstrates that the inclusion of dry mushroom powder has the ability to mimic the “fattiness” of chicken patties.
The findings on the CEUS of diffuse large B cell lymphoma in abdomen: A case report and literature review
Authors: Zhang Yu-Qing , Wang Xin-Yue , Huang Ying 
Published: February 2023

BackgroundPET-CT is the first choice for the imaging diagnosis of intraperitoneal lymphomas. Contrast-enhanced ultrasound (CEUS) is rare in the diagnosis of intraperitoneal nodal lymphoma.Case summaryA 62-year-old man was admitted for examination with “right upper abdominal pain”. Ultrasound was used to refer to the masses in the hilar region, spleen, and anterior sacral region respectively. The masses were all hypoechoic, and blood flow signals could be detected by CDFI. Laboratory tests of CA125 were within normal limits. CEUS examination was performed on the three masses respectively. The three masses showed different perfusion patterns. Thickened vessels appeared around the mass in the hilar region, a peripheral centrally directed perfusion pattern was observed in the splenic mass, and blood supply vessels appeared in the center of the presacral mass with a significant filling defect. They all showed a contrast pattern with rapid clearance and hypoenhancement compared with the surrounding areas. Ultrasound guided needle biopsy revealed non-Hodgkin’s lymphoma, diffuse large B-cell lymphoma, non-germinal center origin. After biopsy, the patient was treated with R-CHOP regimen for chemotherapy, and the tumor disappeared by routine ultrasound review after 5 cycles of chemotherapy.ConclusionTo the best of our knowledge, this report is the first to describe the findings of CEUS in intraperitoneal nodal lymphoma. CEUS has various manifestations in intraperitoneal nodal lymphoma. Future studies are still needed to explore the diagnostic features of CEUS in intraperitoneal nodal lymphoma.
Global research status and trends of bronchiectasis in children from 2003 to 2022: A 20-year bibliometric analysis
Authors: Gong Ting , Wang Xueer , Li Shuanglian , Zhong Li , Zhu Lin , Luo Tingting , Tian Daiyin 
Published: February 2023

BackgroundThis study aims to analyze the research hotspots, evolution, and developing trends in pediatric bronchiectasis over the past 20 years using bibliometric analysis and visualization tools to identify potential new research directions.MethodsPublications related to bronchiectasis in children were retrieved from the Web of Science Core Collection (WoSCC) database from 2003 to 2022. Knowledge maps were performed through VOSviewer1.6.18 and CiteSpace6.1 R2.ResultsA total of 2,133 publications were searched, while only 1,351 original articles written in English between 2003 and 2022 were incorporated. After removing duplicates, we finally included 1,350 articles published by 6,593 authors from 1,865 institutions in 80 countries/regions in 384 different academic journals with an average citation frequency of 24.91 times. The number of publications shows an extremely obvious binomial growth trend. The majority of publications originated from the United States, Australia, and England. The institutes in Australia, especially Charles Darwin University, published the most articles associated with pediatric bronchiectasis. In addition, Pediatric Pulmonology was the most published journal. In terms of authors, Chang AB was the most productive author, while Gangell CL had the highest average citation frequency. The five keywords that have appeared most frequently during the last two decades were “children,” “cystic fibrosis,” “bronchiectasis,” “ct,” and “pulmonary-function.” According to keyword analysis, early diagnosis and intervention and optimal long-term pediatric-specific management were the most concerned topics for researchers.ConclusionThis bibliometric analysis indicates that bronchiectasis in children has drawn increasing attention in the last two decades as its recognition continues to rise, providing scholars in the field with significant information on current topical issues and research frontiers.
Potentially clinically significant drug-drug interactions in older patients admitted to the hospital: A cross-sectional study
Authors: Očovská Zuzana , Maříková Martina , Vlček Jiří 
Published: February 2023

Background: An international consensus list of potentially clinically significant drug-drug interactions (DDIs) in older people has been recently validated. Our objective was to describe the prevalence and characteristics of drug combinations potentially causing clinically significant DDIs identified in the medication history of older patients admitted to the hospital and the prevalence and characteristics of manifest DDIs–DDIs involved in adverse drug events present at hospital admission, DDIs that contributed to ADE-related hospital admissions, and DDIs involved in drug-related laboratory deviations.Methods: The data were obtained from our previous study that examined the drug-relatedness of hospital admissions to University Hospital Hradec Králové via the department of emergency medicine in the Czech Republic. Patients ≥ 65 years old were included. Drug combinations potentially causing clinically significant DDIs were identified using the international consensus list of potentially clinically significant DDIs in older people.Results: Of the 812 older patients admitted to the hospital, 46% were exposed to drug combinations potentially causing clinically significant DDIs. A combination of medications that affect potassium concentrations accounted for 47% of all drug combinations potentially causing clinically significant DDIs. In 27 cases, potentially clinically significant DDIs were associated with drug-related hospital admissions. In 4 cases, potentially clinically significant DDIs were associated with ADEs that were present at admissions. In 4 cases, the potentially clinically significant DDIs were associated with laboratory deviations. Manifest DDIs that contributed to drug-related hospital admissions most frequently involved antithrombotic agents and central nervous system depressants.Conclusion: The results confirm the findings from the European OPERAM trial, which found that drug combinations potentially causing clinically significant DDIs are very common in older patients. Manifest DDIs were present in 4.3% of older patients admitted to the hospital. In 3.3%, manifest DDIs contributed to drug-related hospital admissions. The difference in the rates of potential and manifest DDIs suggests that if a computerized decision support system is used for alerting potentially clinically significant DDIs in older patients, it needs to be contextualized (e.g., take concomitant medications, doses of medications, laboratory values, and patients’ comorbidities into account).
Effects of aquatic exercise on the improvement of lower-extremity motor function and quality of life in patients with Parkinson’s disease: A meta-analysis
Authors: Dai Shengyu , Yuan Haoteng , Wang Jiahui , Yang Yuhang , Wen Shilin 
Published: February 2023

Objective: To systematically evaluate the effect of aquatic exercise interventions on the improvement of lower-extremity motor function and quality of life in patients with Parkinson’s disease.Methods: Two researchers independently searched the literature using the PubMed, Web of Science, Embase, and Cochrane Library databases. The search period was from the establishment of the database to December 2021. The subject heading search included “hydrotherapy,” “hydro therapies,” “hydro therapeutics,” “water therapy,” “aquatic exercise therapy,” “aquatic therapy,” “water-based exercise,” “Parkinson,” “Parkinson disease,” “Parkinson’s disease,” “Parkinson’s syndrome,” “primary Parkinsonism,” “paralysis agitans,” and “randomized controlled trial (RCT).”Result: A total of 698 articles were retrieved from the four databases by searching for subject headings, and 10 RCT articles were finally included. The balance ability of aquatic exercise in patients with Parkinson’s disease (weighted mean differences [WMD] = 2.234, 95% CI: 1.112–3.357, Z = 3.9, p &lt; 0.01), walking ability (WMD = −0.911, 95% CI: −1.581 to −0.241, Z = 2.67, p &lt; 0.01), and quality of life (WMD = −5.057, 95% CI: −9.610 to −0.504, Z = 2.18, p = 0.029) were improved, but there was no significant difference in motor function (WMD = −0.328, 95% CI: −1.781 to 1.125, Z = 0.44, p = 0.658).Conclusion: Compared with conventional rehabilitation therapy, aquatic exercise can effectively improve balance, walking ability, and quality of life in patients with Parkinson’s disease. However, it had no obvious effect on improving motor function. This study was limited by the number and quality of the included studies, and more high-quality studies are needed to verify this.Systematic Review Registration:https://www.crd.york.ac.uk/prospero/, identifier CRD42022365103.
Survival on land: A dark-grown seedling searching for path
Authors: Gong Hao , Zeng Zhiwei , Tessier Léa , Guzman Leno , Yuan Zihao , Li Shuai , Zheng Wenhan , Chen Ying , Qi Long 
Published: February 2023

To initiate its development into a plant, a small dark-grown seedling (prior to its emergence from the ground) must penetrate through the growth media. The path that the seedling takes during this journey has yet to be explained. As such, we conducted non-destructive tests using CT scans to observe the growth of dark-grown seedlings in soil over time; we also developed a model to simulate the dynamics of an emerging seedling, and to examine effects of various growth medium conditions, including Lunar soil. It was previously postulated that, with gravitropism in a terrestrial growth medium, a dark-grown seedling would grow directly upright. However, our CT scan results showed that dark-grown soybean seedlings departed from the vertical path in soil, as far as a lateral distance of approximately 10 mm. The phenomenon of the non-straight path was also demonstrated by the model results. Through simulations, we found that an emerging seedling naturally weaves through the particles of growth medium, in search for the path of least resistance. As a result, the seedling ends up travelling a longer distance. Compared with a seedling that was artificially forced to take a straight path in a growth media, the seedling taking the natural path encountered significantly lower resistances (20% lower) from the growth medium, while travelled 12% longer distance during the emergence process. A seedling encountered a much higher impedance in Lunar soil. Our results suggest that taking the path of least resistance, in addition to shaping and orientating itself for mechanical advantage, are strategies evolved by plant species that have contributed to its vast success. An understanding of plant behavior and survival strategies on Earth lay the foundation for future research in agriculture in novel environments, including on celestial bodies.
Electroconvulsive therapy use for refractory status epilepticus in an implantable vagus nerve stimulation patient: A case report
Authors: Katzell Lauren , Beydler Emily M. , Holbert Richard , Rodriguez-Roman Laura , Carr Brent R. 
Published: February 2023

IntroductionStatus epilepticus (SE) has a mortality rate of 20 to 50%, with acute symptomatic SE having a higher risk compared to chronic SE. Electroconvulsive therapy (ECT) has been utilized for the treatment of refractory SE with a success rate estimate of 57.9%. There are no known reported cases of concomitant use of vagus nerve stimulation (VNS) and ECT for the treatment of super refractory SE (SRSE) available in the literature.Case descriptionWe present a 44-year-old female with a history of developmental delay, epilepsy, an implantable VNS for 6 years, and traumatic brain injury with subsequent hygroma who presented with progressive aphasia, declining mental status, and daily generalized seizures lasting up to 20 min. Seizures had increased from her baseline of one seizure per day controlled with topiramate 200 mg three times daily and lamotrigine 400 mg twice daily. She was diagnosed with SRSE after being intubated and placed on eight anti-epileptic drugs (AEDs) that failed to abort SE. ECT was attempted to terminate SE. Due to a prior right craniotomy with subsequent right hygroma, eight treatments of ECT were performed over three sessions using a right anterior, left temporal (RALT) and subsequently a bitemporal electrode placement. The VNS remained active throughout treatment. Various ECT dosing parameters were attempted, varying pulse width and frequency. Although ECT induced mild transient encephalographic (EEG) changes following ECT stimulations, it was unable to terminate SE.DiscussionThis case describes various treatment strategies, constraints, and device limitations when using ECT for the treatment of SE. With wide variability in efficacy rates of ECT in the treatment of SE in the literature, successful and unsuccessful cases offer information on optimizing ECT total charge dose and parameters that yielded success. This case demonstrates an instance of ECT inefficacy in the treatment of SRSE. Here, we discuss the rationale behind the various ECT settings that were selected, and constraints arising from the antiepileptic burden, VNS, and intrinsic limitations of the ECT device itself.
Pilot fatigue survey: A study of the mutual influence among fatigue factors in the “work” dimension
Authors: Jun-Ya Sun , Rui-Shan Sun 
Published: February 2023

BackgroundFatigue risk management for pilots has received increasing attention. The existing fatigue management systems have detailed descriptions of the factors and the mutual influences among the factors that affect the dimension of “sleep”, which is one of the most important causes of fatigue. However, the analysis of the influencing factors of the “work” dimension of fatigue causes has not been very detailed or accurate, especially the exploration of the mutual influence among many fatigue-influencing factors in the “work” dimension.ObjectiveThe purpose of this study was to explore the mutual influence among fatigue-influencing factors related to the “work” dimension in the analysis of pilot fatigue causes.MethodsThis study designed a questionnaire on the dimension of “work” in the causes of pilot fatigue and collected a total of 270 feedback data points from international flight pilots. Based on the questionnaires and data, descriptive statistical analysis, exploratory factor analysis and confirmatory factor analysis were performed to explore the influencing factors and their mutual influences on the “work” dimension of pilot fatigue.ResultsThere is a strong, mutual influence relationship among the fatigue causes of long-haul flight pilots – working status, working conditions and working schedules – in the dimension of “work”. The workload only has a strong correlation with the working schedule, and the interaction relationships with the working status or working conditions are weak.ConclusionThis study analyses the mutual influence among the influencing factors of the “work” dimension of pilot fatigue, and we expect to provide empirical data for pilot fatigue risk management and to help improve fatigue risk management systems.
Exploring the threshold for the start of respiratory syncytial virus infection epidemic season using sentinel surveillance data in Japan
Authors: Miyama Takeshi , Kakimoto Kensaku , Iritani Nobuhiro , Nishio Takayuki , Ukai Tomohiko , Satsuki Yuka , Yamanaka Yasutaka , Nishida Yoko , Shintani Ayumi , Motomura Kazushi 
Published: February 2023

IntroductionAn unusual seasonality of respiratory syncytial virus (RSV) infection in Japan is observed in recent years after 2017, becoming challenging to prepare for: a seasonal shift from autumn–winter to summer–autumn in 2017–2019, no major epidemic in 2020, and an unusually high number of cases reported in 2021.MethodsTo early detect the start-timing of epidemic season, we explored the reference threshold for the start-timing of the epidemic period based on the number of cases per sentinel (CPS, a widely used indicator in Japanese surveillance system), using a relative operating characteristic curve analysis (with the epidemic period defined by effective reproduction number).ResultsThe reference values of Tokyo, Kanagawa, Osaka, and Aichi Prefectures were 0.41, 0.39, 0.42, and 0.24, respectively.DiscussionThe reference CPS value could be a valuable indicator for detecting the RSV epidemic and may contribute to the planned introduction of monoclonal antibody against RSV to prevent severe outcomes.
Systematic map of the most recent evidence (2010–2019) on ruminant production-limiting disease prevalence and associated mortality in Ethiopia
Authors: Tsouloufi Theodora K. , MacVicar Isla S. , Donnison Louise M. , Smyth Karen L. , Peters Andrew R. 
Published: February 2023

BackgroundEthiopia's livestock sector supports the livelihoods of millions of smallholder farmers. However, despite the improvements of recent years, livestock productivity remains low due to critical constraints, including infectious diseases. The aim of this study was to collate and synthesize the published evidence on ruminant disease frequency and disease-associated mortality in Ethiopia, by identifying knowledge gaps and clusters in the literature to provide the basis for a decision-making tool.MethodsSearches on both bibliographic and organization databases were conducted in English and were restricted to the period 2010–2019. Search results were screened for relevance at title, abstract and full text level.ResultsThere were 716 articles identified relevant to the research question. The systematic map revealed an increased publication output from 2012–2017, compared to 2010–2011 and 2018–2019. Most studies were conducted in Oromia, Amhara and SNNPR. A substantial body of evidence was found for trypanosomosis, ectoparasite infestation, fasciolosis, nematodiasis, echinococcosis, and brucellosis.ConclusionThis study suggests that despite the high output of epidemiological publications, further understanding of a considerable number of diseases is required and where evidence is abundant, synthesis of information should be carried out in order to better inform decisions on disease control priorities in the livestock sector.
The Role of Quorum Sensing in the Development of Microcystis aeruginosa Blooms: Gene Expression
Authors: Lamas-Samanamud Gisella , Montante Armando , Mertins Andrea , Phan Duc , Loures Carla , Naves Fabiano , Reeves Tony , Shipley Heather J. 
Published: February 2023

Microcystis aeruginosa (M. aeruginosa) is the dominant cyanobacterial species causing harmful algal blooms in water bodies worldwide. The blooms release potent toxins and pose severe public health hazards to water bodies, animals, and humans who are in contact with or consume this water. The interaction between M. aeruginosa and heterotrophic bacteria is thought to contribute to the development of the blooms. This study strives to provide a specific answer to whether quorum sensing is also a potential mechanism mediating the interaction of different strains/species and the expression by gene luxS or gene mcyB in M. aeruginosa growth. The luxS gene in M. aeruginosa PCC7806 is associated with quorum sensing and was tested by q-PCR throughout a 30-day growth period. The same was performed for the mcyB gene. Heterotrophic bacteria were collected from local water bodies: Cibolo Creek and Leon Creek in San Antonio, Texas. Results revealed that in algal bloom scenarios, there is a similar concentration of gene luxS that is expressed by the cyanobacteria. Gene mcyB, however, is not directly associated with algal blooms, but it is related to cyanotoxin production. Toxicity levels increased in experiments with multiple algal strains, and the HSL treatment was not effective at reducing microcystin levels.
Short interference fringe and high event rate of two-photon interference using up-converted photon pairs
Authors: Syouji Atsushi , Shimizu Ryosuke , Nagano Shigehiro , Suizu Koji , Edamatsu Keiichi 
Published: February 2023

Abstract
We demonstrate a hybrid approach to detecting a short fringe period of two-photon interference with high brightness, by combining spontaneous parametric down-conversion (SPDC) and up-conversion techniques. Photon pairs were generated at the wavelength of 1550 nm via SPDC, and converted to 516.7 nm through up-conversion process with the pump light 775 nm in efficiency ∼90%. The two-photon interference of the up-converted photon pairs exhibited a fringe period of 258.3 nm with high event rate (∼2000 counts s−1), which was 6 times shorter than the original wavelength, demonstrating that the energy-time correlation of the photon pairs was preserved. The technique simultaneously provides short fringe period beyond the classical limit and high brightness of the photon pairs.
Fabrication and scintillation properties of a flexible optical-guiding crystal scintillator
Authors: Yajima Ryuga , Kamada Kei , Murakami Rikito , Kutsuzawa Naoko , Sasaki Rei , Yoshino Masao , Horiai Takahiko , Kim Kyoung Jin , Kochurikhin Vladimir V. , Yamaji Akihiro , Kurosawa Shunsuke , Yokota Yuui , Sato Hiroki , Toyoda Satoshi , Ohashi Yuji , Hanada Takashi , Yoshikawa Akira 
Published: February 2023

Abstract
Scintillation properties of a flexible optical-guiding crystal scintillator with a thallium-doped CsI (Tl:CsI) crystal and borosilicate glass as the core and cladding, respectively, are reported. The as-fabricated optical-guiding crystal scintillator exhibits a light yield of 31,000 photons MeV−1 under 662 keV γ-ray irradiation. The recrystallized sample is transparent and provides a higher light yield of 54,000 photons MeV–1, which is comparable to that of single-crystal Tl:CsI. The decay times are 400 ns (28%) and 1,350 ns (72%). This material can serve as a scintillator fiber with high sensitivity to γ- and X-rays, high light yield, and energy discrimination.