bluuebunny/crossref_metadata_2025_split huggingface dataset:
Weed control with small ruminants: Exploratory evaluation on Senecio inaequidens
Authors: Sánchez Valdés Jair Jesús , López González Felipe , De Jesús Sebastián Omar , Sainz Ramírez Aurora , Martínez García Carlos Galdino , Arriaga Jordán Carlos Manuel 
Published: December 2022

Objective: Carry out an exploratory evaluation of sheep and goats grazing in a temperate pasture invaded by Senecio inaequidens, as a means of biological control of weeds in small-scale dairy systems (SSDS).
Methodology: Crude protein (CP), neutral detergent fibre (NDF), and acid detergent fibre (ADF) were determined on pasture and Senecio samples. The effect of grazing by sheep and goats on the pasture was assessed by means of the height, density and soil cover of Senecio, and also sward height; and the live weight of the animals, daily weight gain and body condition score were recorded. Statistical analysis was by a 2x2 factorial design, with species (sheep or goat) and two grazing intensities at 28.3 or 50.3 m2/animal per day.
Results: height, coverage and density of Senecio did not show significant differences (P>0.05), neither did sward height. The chemical composition of the pasture did not show statistically significant differences for the assessed periods either. Animal weight, body condition and daily weight gain did not show significant differences among the evaluated treatments (P>0.05).
Implications: This is the first report evaluating sheep and goat grazing to control of Senecio invasion in temperate pasture in central Mexico. In addition, knowing the chemical quality of Senecio will allow decisions to be made for supplementation in grazing systems with sheep or goats.
Conclusions: The grazing of sheep and goats reduced the number of Senecio plants in the assessed pasture, which indicates the possibility of controlling this weed by grazing sheep or goats over longer-term grazing.
Polyhydroxyalkanoates from pear (Pyrus communis L) waste by Bacillus subtilis
Authors: Hernández-Manjarrez Cynthia Estefania , Cortés-Sánchez Alejandro De Jesús , Fabela-Morón Miriam F. , Rayas-Amor Adolfo A. , Díaz-Ramírez Mayra 
Published: December 2022

Objective: Analyze the production of polyhydroxyalkanoates (PHA) by Bacillus subtilis sp., subtilis in submerged culture using pear residues as a carbon source.
Design/methodology/approach: The culture consisted of pear residue flour concentrations of 5 and 15 % for 72 h. Reducing sugars, biomass, pH, protein, and pHA extraction and quantification were analyzed during submerging cultivation of Bacillus subtilis sp., subtilis
Results: The results showed that Bacillus subtilis sp., subtilis can grow and generate PHA, having its maximum proportion in PHA extract of 0.094 g/L at 72h of culture, at a substrate concentration of 5%.
Study limitations/implications: More studies related to the optimization of culture conditions for PHA production are required and prior treatment of pear waste flour will be considered.
Findings/Conclusions: The synthesis of these biopolymers is important to promote their large-scale production using agro-industrial waste, thus contributing to reduce the environmental impact.
Konsep Pendidikan Akhlak Ibnu Miskawaih
Authors: Ramli Mohammad , Zamzami Della Noer 
Published: December 2022

Penelitian ini berisikan mengenai konsep pendidikan akhlak Ibnu Miskawaih, yang mana penelitian ini mengkaji pemikiran Ibnu Miskawaih yang berkenanan dengan pendidikan akhlak. Selain itu penelitian ini juga membahas apakah konsep pendidikan Ibnu Miskawaih masih relevan jika digunakan pada saat ini. Penelitian ini bertujuan untuk mengetahui bagaimana konsep pendidikan Ibnu Miskawaih serta relevansinya. Penelitian ini merupakan penelitian kajian pustaka yang menggunakan jenis data primer dan data sekunder. Teknik pengumpulan data yang digunakan adalah dokumentasi yang mana data yang didapat merupakan kata-kata yang berasal dari sumber-sumber terpercaya seperti buku jurnal dan lainnya. Teknik analisis data yang digunakan adalah teknik deskriptif, teknik analisis data bahasa inklusif dan analogal, dan analisis induksi dan deduksi. Hasil penelitian ini adalah Ibnu Miskawaih menjelaskan bahwa seseorang harus membersihkan jiwanya terlebih dahulu sehingga akhlak yang baik akan dengan mudah untuk tertanam dalam diri. Dalam buku Tahdzib Al-Akhlak manusia hendaklah memiliki empat pokok akhlak yang mana empat pokok tersebut adalah kunci untuk mendapatkan akhlak yang baik lainnya. Konsep pendidikan akhlak Ibnu Miskawaih masih sangat relevan jika digunakan pada saat ini karena masih sejalan dengan konsep pendidikan nasional yang ingin melahirkan generasi yang berakhlak mulia.
Pelatihan Pembuatan LPG PETAI (Loose Parts Berbasis Geografis Pesisir Pantai) Bagi Guru TK di Desa Tambakmulyo
Authors: Pamungkas Candra Adi , Khikmah Nurul , Nur Septiyani Rohmah , Setyarini Heni , Roswita Peruminingsih Anna 
Published: December 2022

Pilihan media dalam bermain harus dapat merangsang perkembangan beberapa aspek anak. Salah satunya adalah penggunaan loose part. Berdasarkan media bagian lepas, taman anak-anak hari ini membutuhkan bahan loose part untuk dukungan pembelajaran sang anak. Salah satunya adalah TK Muslim Bina Muslim Tambakmulyo, yang terletak di dekat pantai, terdapat banyak bahan pendukung pembelajaran dengan bagian yang loose part tetapi tidak cukup dimanfaatkan. Metode pelaksanaan pelatihan ini meliputi persiapan dan perencanaan yang meliputi observasi, perencanaan manajemen dan persiapan sarana dan prasarana. Selanjutnya adalah tahap implementasi pelatihan Konsep dasar loose part, kebutuhan bermainnya AUD, jenis dan prinsip AUD media pembelajaran membuat loose part. Dilanjutkan dengan tahap evaluasi pelatihan. Hal ini dilakukan agar guru TK khususnya mendapat informasi belajar menggunakan bagian lepas yang bisa digunakan kedepannya. Hasil dari pelatihan ini yaitu menambahkan pemahaman guru TK sebagai peserta pelatihan tentang kalimat pemantik, dan strategi cara penggunaan loose part serta bagaimana cara mengolah hingga dapat membuat loose part sendiri.
Bahaya Apatisme Pemuda terhadap Kehidupan Bernegara: Edukasi Partisipasi Politik Karang Taruna Ira Kusuma Yogyakarta
Authors: Hapsari Murti Ayu , Wardhani Sri Handayani Retna , Ariyani Nita , Andani Devi 
Published: December 2022

Tujuan penulisan ini adalah mensosialisasikan secara tertulis tentang partisipasi politik terhadap pemuda yang merupakan hal yang layaknya dilakukan secara berkelanjutan. Negara demokrasi yang sehat membutuhkan partisipasi warga negara, khususnya pemuda yang berkualitas untuk bisa tetap melanjutkan eksistensinya. Tim Pengabdi Fakultas Hukum Universitas Janabadra berusaha untuk menanamkan pengetahuan tentang pentingnya partisipasi politik serta bahayanya sikap apatis terhadap kebijakan pemerintah. Sosialisasi ini bertujuan untuk memberikan pemahaman serta meningkatkan kesadaran Pemuda Karang Taruna Ira Kusuma di Yogyakarta terkait dengan pendidikan politik, sedangkan tujuan penulisan adalah untuk mempublikasikan lebih lanjut mengenai kegiatan tersebut. Metode pelaksanaan terdiri dari dua tahap yaitu tahap persiapan serta tahap pelaksanaan sosialisasi. Keseluruhan rangkaian berjalan dengan baik dengan meningkatnya pemahaman pemuda Karang Taruna Ira Kusuma terkait pentingnya partisipasi politik. The purpose of this paper is to socialize in writing about political participation in youth which is something that should be done on an ongoing basis. A healthy democracy requires the participation of citizens, especially qualified youth to be able to continue their existence. Janabadra University's Faculty of Law Service Team seeks to instill knowledge about the importance of political participation as well as the dangers of apathy towards government policies. This socialization aims to provide understanding and increase awareness of the Karang Taruna Ira Kusuma Youth in Yogyakarta related to political education, while the purpose of writing is to publish more about the activity. The implementation method consists of two stages, namely the preparatory stage and the socialization implementation stage. The whole series went well with the increasing understanding of “Karang Taruna” youth Ira Kusuma regarding the importance of political participation.
La primitiva Virgen de Consolación de la Hermandad de la Buena Muerte de Huelva
Authors: Calvo Lázaro Rocío 
Published: December 2022

La hermandad de la Buena Muerte de Huelva se fundó en 1921, y se ubicó en la capilla del colegio de los Agustinos. La hermandad comenzó a procesionar en la tarde del Viernes Santo.
La imagen de la Virgen de la Consolación debía de datar de la primera mitad del siglo XVIII y su origen puede estar en la extinta hermandad del Dulce Nombre. Era de autor desconocido.
Desgraciadamente, la Virgen fue destruida en el incendio provocado al convento de las Madres Agustinas, el 21 de julio de 1936, durante la Guerra Civil española.
Targeting N-type calcium channels in young-onset of some neurological diseases
Authors: Antunes Flavia Tasmin Techera , De Souza Alessandra Hubner , Figueira Juliana , Binda Nancy Scardua , Carvalho Vanice Paula Ricardo , Vieira Luciene Bruno , Gomez Marcus Vinícius 
Published: December 2022

Graphical AbstractN-type calcium channels dysregulation and neurotransmission impairment Early-onset of neurological conditions, like Huntington’s disease, Multiple Sclerosis, and Migraine demonstrate harmful processes, such as neuroinflammation, neurodegeneration, and conditions like pain. N-type voltage-gated calcium channels are responsible for the exacerbated calcium influx that triggers neurotransmitter release.
Butenolide derivatives from Aspergillus terreus selectively inhibit butyrylcholinesterase
Authors: Cui Xiang , Deng Shanshan , Li Guoyin , Zhang Yunxia , Wang Lining , Wu Changjing , Deng Yanru 
Published: December 2022

Two undescribed butenolide derivatives, asperteretal J (1) and K (2), together with 13 known ones (3–15) were isolated from an endophytic fungus Aspergillus terreus SGP-1, the fermentation product of which exhibited selective inhibitory activity toward butyrylcholinesterase. The structures of the new compounds were elucidated based on HRMS and NMR data, and the absolute configurations were determined by specific optical rotation comparison. All compounds were evaluated for cholinesterase inhibitory effects with galantamine as a positive control. Compounds 4–8 selectively inhibited butyrylcholinesterase with IC50 values of 18.4–45.8 µM in a competitive manner, with Ki values of 12.3–38.2 µM. The structure-activity relationship was discussed. Molecular docking and dynamic simulation of the inhibitor-enzyme complex were performed to better understand the interactions.
Advances in wound repair and regeneration: Systematic comparison of cell free fat extract and platelet rich plasma
Authors: Zhang Lifang , Hu Chengjun , Xu Wenqing , Wu Dingyu , Lei Shaorong 
Published: December 2022

Background: Previous studies showed Cell free fat extract (CEFFE) and Platelet rich plasma (PRP) could effectively accelerate wound healing. However, the comparative study on curative effect is still lacking. A systematic comparison could provide more theoretical support and laboratory basis for the clinical application of CEFFE and PRP.Objective: To compare the efficacy of CEFFE and PRP in promoting skin wound repair.Methods: CEFFE and PRP were prepared according to the literature. The wound repair related factors were measured and compared. In vitro, the effects of both on cell migration, proliferation and tube formation were compared. In vivo, wound healing rate was measured on the 1st, 3rd, 9th, and 12th days after skin injury and treatment. Then the specimens were cut off for histological analysis.Results: Although the total protein content of PRP was significantly around 19 times higher than that of CEFFE, there was no statistical difference in the content of BDNF, EGF and VEGF between CEFFE and PRP. Even the NT-3 content of CEFFE was just slightly higher than that of PRP. The concentration of b-FGF, HGF and TGF-β and PDGF-BB in PRP is higher than that in CEFFE, but there is only a very small difference between them. In vitro, PRP showed better efficacy than CEFFE in promoting fibroblast proliferation while there was no significant difference in promoting angiogenesis and fibroblast migration. Both PRP and CEFFE could significantly promote wound healing in mice. There was no statistical difference in wound healing between CEFFE and PRP groups in vivo. Immunohistochemical staining of Ki67&amp;CD31 showed that there was no significant difference between PRP and CEFFE groups.Conclusion: The effect of PRP and CEFFE in promoting wound healing was similar. In clinical practice, the acquisition of PRP is relatively more convenient. Containing no cells, CEFFE has the advantage of easier preservation. For patients who have discarded adipose tissue, or contraindications to PRP technology, CEFFE technology may provide a new option for skin wound repair.
Using Facebook, Instagram, and Pinterest advertising campaigns to increase enrollment in newborn screening research
Authors: McInnis Stephanie , Sobolewski Jessica , Dass Manisha , Gehtland Lisa M. , Bailey Donald B. 
Published: December 2022

IntroductionSocial media ad campaigns can be an efficient, cost-effective way to recruit for studies online, especially as the onset of the COVID-19 pandemic limited in-person recruitment. Early Check, a large ongoing study offering testing for a panel of conditions for all newborns in North Carolina, uses social media ad campaigns, along with direct mail, email, print materials in health care settings, and messages through patient portals to contact pregnant women and mothers with eligible newborns. All materials refer women to the online Early Check portal for consent and enrollment in the study.MethodsTo evaluate social media options for outreach and recruitment, we ran two paid ad campaigns on Pinterest in May and July 2021 and compared performance to simultaneous Facebook and Instagram campaigns.ResultsFacebook and Instagram cost $136.53 per sign-up in May and July. Our first Pinterest campaign in May resulted in 206,416 impressions, 529 link clicks, and a cost per sign-up of $536.56. After adjusting the campaign to incorporate lessons learned about the platform, the second Pinterest campaign in July resulted in 225,286 impressions, 621 link clicks, and a cost per sign-up of $216.55.DiscussionOthers looking to implement social media ad campaigns for public health recruitment should note that ad costs have increased since 2020. However, social media ad campaigns on Facebook, Instagram, and Pinterest remain a cost-effective and convenient way to recruit participants for studies, especially when in-person efforts are not feasible. Ad campaign strategy should also be tailored to the specific platform. Facebook and Instagram ads should be run together in the same campaign to optimize the budget across both platforms and should run using an on-off schedule. Pinterest campaigns should run for a longer period to optimize continually for sign-ups over time.
Effect of exercise on vascular function in hypertension patients: A meta-analysis of randomized controlled trials
Authors: Zhou Huayi , Wang Shengya , Zhao Changtao , He Hui 
Published: December 2022

ObjectiveThe purpose of this study was to systematically evaluate the effect of exercise on vascular function in patients with pre- and hypertension.MethodsA systematic review of articles retrieved via the PubMed, Embase, EBSCO, and Web of Science databases was conducted. All the randomized controlled trials published between the establishment of the databases and October 2022 were included. Studies that evaluated the effects of exercise intervention on vascular function in patients with pre- and hypertension were selected.ResultsA total of 717 subjects were included in 12 randomized controlled trials. The meta-analysis showed that in patients with pre- and hypertension, exercise can significantly reduce systolic blood pressure (SBP) (MD = –4.89; 95% CI, –7.05 to –2.73; P &lt; 0.00001) and diastolic blood pressure (DBP) (MD = –3.74; 95% CI, –5.18 to –2.29; P &lt; 0.00001) and can improve endothelium-dependent flow-mediated dilatation (MD = 2.14; 95% CI, 1.71–2.61; P &lt; 0.00001), and exercise did not reduce pulse wave velocity (PWV) (MD = 0.03, 95% CI, –0.45–0.50; P = 0.92). Regression analysis showed that changes in exercise-related vascular function were independent of subject medication status, baseline SBP, age and duration of intervention.ConclusionAerobic, resistance, and high-intensity intermittent exercise all significantly improved SBP, DBP, and FMD in pre- and hypertensive patients, however, they were not effective in reducing PWV, and this effect was independent of the subject’s medication status, baseline SBP, age and duration of intervention.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/, identifier CRD42022302646.
The association between iliac vein compression degree and characteristics of first diagnosed left lower extremity deep vein thrombosis
Authors: Shi Yadong , Yuan Yuan , Gong Maofeng , Su Haobo , Chen Liang , Huang Hao , Lu Zhaoxuan , Zhou Yangyi , Gu Jianping 
Published: December 2022

ObjectiveThis study aimed to investigate the association between the left common iliac vein (CIV) compression degree and characteristics of first diagnosed left lower extremity deep vein thrombosis (DVT).Patients and methodsThis was a single-center retrospective observational study. Between January 2015 and June 2022, first diagnosed left lower extremity DVT patients with enhanced computed tomography of lower extremities were included. Patient demographics, comorbidities, risk factors, DVT characteristics, and CIV compression degree were collected and analyzed. Logistic regressions were performed to evaluate the odds ratio (OR) with a 95% confidence interval (CI) of iliofemoral or mixed DVT vs. compression percentage. The association between compression percentage and iliofemoral or mixed DVT was evaluated on a continuous scale with restricted cubic splines (RCS). The association between compression percentage and thrombus burden was evaluated using the Spearman test.ResultsA total of 196 (mean age, 61.8 ± 16.1 years; 86 males) patients were included. The median CIV compression percentage in iliofemoral or mixed DVT patients was significantly greater than in non-iliofemoral or non-mixed DVT, respectively (64.4 vs. 46.6%, p &lt; 0.001; 67.8 vs. 54.8%, p = 0.004). CIV compression &gt;50% was associated with significantly increased morbidity of iliofemoral DVT (adjusted OR, 2.96; 95% CI, 1.58–5.52; p = 0.001) or mixed DVT (adjusted OR, 2.39; 95% CI, 1.19–4.81; p = 0.014). RCS showed that a greater compression percentage was associated with a continuously increased OR of iliofemoral DVT (overall p = 0.003, non-linear p = 0.577) or mixed DVT (overall p = 0.020, non-linear p = 0.771). CIV compression percentage had a positive correlation with thrombus burden (rs = 0.284, p &lt; 0.001).ConclusionA greater left CIV compression percentage may be associated with increasing likelihood of more proximal location and severe clot extent in first diagnosed left lower extremity DVT.
Validation of a rapid remote digital test for impaired cognition using clinical dementia rating and mini-mental state examination: An observational research study
Authors: Alim-Marvasti Ali , Kuleindiren Narayan , Harvey Kirsten , Ciocca Matteo , Lin Aaron , Selim Hamzah , Mahmud Mohammad 
Published: December 2022

BackgroundThe Clinical Dementia Rating (CDR) and Mini-Mental State Examination (MMSE) are useful screening tools for mild cognitive impairment (MCI). However, these tests require qualified in-person supervision and the CDR can take up to 60 min to complete. We developed a digital cognitive screening test (M-CogScore) that can be completed remotely in under 5 min without supervision. We set out to validate M-CogScore in head-to-head comparisons with CDR and MMSE.MethodsTo ascertain the validity of the M-CogScore, we enrolled participants as healthy controls or impaired cognition, matched for age, sex, and education. Participants completed the 30-item paper MMSE Second Edition Standard Version (MMSE-2), paper CDR, and smartphone-based M-CogScore. The digital M-CogScore test is based on time-normalised scores from smartphone-adapted Stroop (M-Stroop), digit-symbols (M-Symbols), and delayed recall tests (M-Memory). We used Spearman's correlation coefficient to determine the convergent validity between M-CogScore and the 30-item MMSE-2, and non-parametric tests to determine its discriminative validity with a CDR label of normal (CDR 0) or impaired cognition (CDR 0.5 or 1). M-CogScore was further compared to MMSE-2 using area under the receiver operating characteristic curves (AUC) with corresponding optimal cut-offs.Results72 participants completed all three tests. The M-CogScore correlated with both MMSE-2 (rho = 0.54, p &lt; 0.0001) and impaired cognition on CDR (Mann Whitney U = 187, p &lt; 0.001). M-CogScore achieved an AUC of 0.85 (95% bootstrapped CI [0.80, 0.91]), when differentiating between normal and impaired cognition, compared to an AUC of 0.78 [0.72, 0.84] for MMSE-2 (p = 0.21).ConclusionDigital screening tests such as M-CogScore are desirable to aid in rapid and remote clinical cognitive evaluations. M-CogScore was significantly correlated with established cognitive tests, including CDR and MMSE-2. M-CogScore can be taken remotely without supervision, is automatically scored, has less of a ceiling effect than the MMSE-2, and takes significantly less time to complete.
Hydrogeochemical origin and circulation of spring waters along the Karakorum fault, Western Tibetan Plateau: Implications for interaction between hydrosphere and lithosphere
Authors: Wang Jingli , Zhou Xiaocheng , He Miao , Li Jingchao , Dong Jinyuan , Tian Jiao , Yan Yucong , Li Ying , Liu Kaiyi , Li Yang 
Published: December 2022

Geochemical investigation on the origin and circulation of geothermal water is crucial for better understanding the interaction between hydrosphere and lithosphere. Previous studies on the Himalayan geothermal belt mainly distributed in the central and eastern Tibetan Plateau. In this study, water samples (8 hot springs and 1 cold spring) from the Karakorum fault (KKF) zone of western Tibetan Plateau were analyzed for the hydrogeochemical characteristics and isotopic compositions. Three types of spring water along the KKF were classified on basis of ionic concentration and Sr isotopic composition: type A water (HCO3–Mg or Ca), type B water (HCO3–Na) and type C water (Cl–Na). Type A water is originated from the infiltration of meteoric water and the dissolution of silicate/evaporite. Type B water is mainly leached from the metamorphic and granitoid rocks. Type C water is formed by the dissolution of chlorides and sulphates. δD and δ18O isotopes indicate that geothermal fluid along the fault zone was mainly recharged by local precipitation. Moreover, reservoir temperatures of 144.2–208.6°C were estimated by the silica–enthalpy mixing model, and the thermal waters have a relatively deep circulation depth (≥ 7.0 km). Meanwhile, the thermal waters are characterized by extremely high Li, B, Fe and As concentrations and earthquakes frequently happened in the vicinity, suggesting that the KKF is a deep and active fault, which also indicates that the thermal fluids are strongly associated with seismicity. Therefore, thermal fluid can potentially be used as continuous monitoring sites for earthquake forecasting.