bluuebunny/crossref_metadata_2025_split huggingface dataset:
Osteopontin as a Tumor Marker in Ovarian Cancer
Authors: Rani Shikha , Sehgal Alka , Kaur Jasbinder , Pandher Dilpreet Kaur , Punia Rajpal Singh 
Published: January 2023

Introduction:
Ovarian cancer is associated with high morbidity and mortality. This is due to the nonspecific symptoms and no effective screening methods. Currently, carbohydrate antigen-125 (CA125) is used as a tumor biomarker for the diagnosis of ovarian cancer, but it has its own limitations. Hence, there is a need for other tumor biomarkers for the diagnosis of ovarian cancer. Objective of the study was to evaluate the diagnostic test characteristics of plasma osteopontin (OPN) in detecting ovarian malignancy and comparing its performance with CA125.

Materials and Methods:
This is a prospective cross-sectional diagnostic test evaluation. Women with adnexal mass detected by clinical or radiological examination were enrolled as suspected cases. Women who presented with other gynecological conditions were enrolled as controls. OPN and CA125 levels were measured in all enrolled subjects.

Results:
Among 106 women enrolled, 26 were ovarian cancer, 31 had benign ovarian masses, and 49 were controls. Median plasma CA125 levels were higher in subjects with ovarian cancer (298 U/ml; interquartile range [IQR]: 84–1082 U/ml vs. 37.5U/ml; IQR: 17.6–82.9U/ml; P < 0.001). CA125 sensitivity, specificity, positive, and negative likelihood ratios were 88.5%, 61.3%, 2.10, and 0.19, respectively. Median plasma OPN levels were higher in subjects with ovarian cancer (63.1 ng/ml; IQR: 39.3–137 ng/ml vs. 27 ng/ml; IQR: 20–52 ng/ml; P = 0.001). Sensitivity, specificity, positive, and negative likelihood ratios of OPN were 50%, 87%, 2.58, and 0.62, respectively.

Conclusion:
OPN levels were higher in ovarian cancer than in the benign ovarian mass and had better specificity than CA125. OPN can better differentiate between benign and malignant ovarian mass as compared to CA125.
Laparoscopic Common Bile Duct Exploration
Authors: Balram Arjun , Harsha Mano , Tadikamalla Viswanath , Nair Sriya Prakash , Varghese C. J. 
Published: January 2023

Background:
Laparoscopic common bile duct exploration (LCBDE) during laparoscopic cholecystectomy (LC) is as effective as two-stage endolaparoscopic treatment but with a shorter hospital stay, lower cost and lower recurrent stone rate.

Aim:
The aim of this article was to report the authors' experience with LCBDE with a rigid telescope during LC.

Methods:
A retrospective analysis of patients who underwent LCBDE for ductal stones in a single surgical unit were studied from 2017 to 2021.

Results:
A total of 55 LCBDEs were performed during this period. Ninety percentage of patients presented with biliary colic. Of these 18% were following endoscopic retrograde cholangiopancreatography failure. About 50.4% of patients had multiple stones. About 16.8% of patients had undilated CBD. The mean operative time was 178 ± 71.62 (80–300). The conversion rate was 1.8%. All patients underwent CBD exploration through a supraduodenal choledochotomy. In 9% of cases, pneumatic lithotripsy was used because of impacted large stones. The closure was done over T-tube in 58.18% of cases and over antegrade endobiliary stent in 41% of cases. Post-operative complication was minor CD 1 and 2. The overall success rate of LCBDE was 98%.

Conclusion:
LCBDE should be considered for treatment for patients with gallstones with CBD stones, especially for patients with large and multiple stones.
Utility of Surgical Apgar Score in Predicting Morbidity and Mortality in Post-Operative Patients
Authors: Jithu T. G. , Firoz Khan M. H. , Halemani Kusuma , Vijayan K. N. 
Published: January 2023

Introduction:
Predicting complications forms an essential part of risk management in surgical practice. Recognising patients at high risk of developing a complication will contribute substantially to the quality of surgery and financial burden. This study aimed to assess the utility of surgical Apgar score in assessing morbidity and mortality in post-operative patients.

Materials a Methods:
The surgical Apgar score was calculated on all patients between 16 and 75 years undergoing surgery that required intensive perioperative monitoring in the general surgery department and correlated the score with the patient's outcomes in the form of complications, including death within 30 days of surgery.

Results:
Among the 214 patients, more than 70.6% of the patients were in the age group of above 40 years. The relationship with the lower surgical Apgar score is significant in terms of predicting post-operative complications (P < 0.001). The most common comorbidities were hypertension (43.9%) and diabetes mellitus (DM) (16.4%). However, the presence of DM and coronary artery disease influenced the outcome significantly. Emergency surgeries were associated with significantly more risk of complication within 30 days of surgery. Prolonged intensive care unit care and ventilation support, sepsis and pneumonia are the major set of post-operative complications in our study. A low surgical Apgar score is associated with an increased likelihood of complications.

Conclusion:
The surgical Apgar system is effective in stratifying patients into high-risk and low-risk groups and anticipating post-operative complications.
LRINEC (Laboratory Risk Indicator for Necrotizing Fasciitis) Scoring System as a Predictor for Early Diagnosis of Necrotizing Fasciitis in Soft-Tissue Infections
Authors: Rajeev C , Safwan A Mohamad , Muhammed Irfan K P C , Vijayan K N , Varghese Liju 
Published: January 2023

Introduction:
Necrotizing soft-tissue infections are often fatal, characterized by extensive necrosis of the fascia and subcutaneous tissues. To aid the early diagnosis of necrotizing fasciitis (NF), there is a Laboratory Risk Indicator for Necrotizing Fasciitis (LRINEC) scoring system for the early diagnosis of NF. Our study was undertaken to evaluate LRINEC score, based on routine laboratory investigations that are readily available, that could help distinguish NF from other soft-tissue infections.

Materials and Methods:
The study was conducted on all inpatients, admitted with features of soft-tissue infections suspected to have NF and later underwent wound debridement or amputation in a tertiary care hospital. LRINEC score more than or equal to 6 was considered as case and the score <6 considered as control. Both were treated with intravenous (IV) antibiotics, IV fluids and surgical intervention based on their clinical findings and outcome. The confirmatory diagnosis for NF was done through culture of tissue and other body fluids.

Results:
The cutoff value of LRINEC for predicting NF was 6 with sensitivity of 85.7% and specificity of 70.7%. The negative predictive value of LRINEC-OC was 87.9% and positive predictive value (PPV) 66.7%. The accuracy was 76.8%.

Conclusion:
LRINEC scoring system has a better PPV in identifying the onset of NF and risk strategizing of the patients with severe soft-tissue infections. We recommend LRINEC score to be used as a predictor in the diagnosis of NF. Multi-disciplinary team may guide immediate operative and supportive management, thereby improving the clinical outcome of the patient.
Validation of Boey's Scoring System in Predicting Short-Term Morbidity and Mortality in Peptic Ulcer Perforation Peritonitis
Authors: Saiphy Geethu , Sunil S. 
Published: January 2023

Aim:
This study aims to assess the validation of Boey's scoring system in predicting short-term morbidity and mortality amongst patients with peptic ulcer perforation (PULP) peritonitis.

Methodology:
110 patients with PULP peritonitis were included in this study. Boey's score was calculated based on three parameters, pre-operative shock, concomitant medical illness and duration of perforation >24 h. All patients with PULP were treated with exploratory laparotomy with peritoneal lavage and omental patch repair and the patients were then followed up throughout the data collection period to look for clinical outcomes. The main outcomes assessed were mortality and short-term morbidity (1 month). Data were analysed using SPSS (IBM, Delhi, India). Chi-square test was used to check for the association between the outcome variables and the categorised Boey's score. The level of statistical significance was assigned as a P < 0.05.

Results:
Amongst the 110 patients, half belonged to the age group of 31–50 years, and 90% were male. The most common site of perforation was the first part of duodenum (78%). The rate of mortality was 10%. With respect to the distribution of the Boey's score, the percentage of patients with Boey's score 0, 1, 2 and 3 was found to be 12.75%, 58.2%, 24.5% and 5%, respectively, and their corresponding mortality was found to be 0%, 4.7%, 25.9% and 40%, respectively. Their morbidity at 1 week was found to be 21.4%, 42.6%, 80% and 100%, respectively, and morbidity at 1 month was found to be 0%, 39.3%, 75% and 100%, respectively.

Conclusion:
There was a significant association between mortality and morbidity at 1 week and at 1 month with the distribution of Boey's score. This highlights the importance of Boey's score in determining the outcome amongst perforated peptic ulcer patients. Boey's score being an easily applicable score for day-to-day clinical practice can aid clinicians in predicting the outcome amongst perforated ulcer patients. Several studies have also shown better accuracy with Boey's scoring system when compared to the other scoring systems.
Cohomologie des fibrés en droites sur $\operatorname{SL}_3/B$ en caractéristique positive : deux filtrations et conséquences
Authors: Liu Linyuan 
Published: January 2023

In this paper, I will prove the existence of two filtrations of the cohomology of line bundles on

\operatorname{SL}_3/B

. The first one is a two-step filtration that exists for

H^1(\mu)

and

H^2(\mu)

if

\mu

is in the Griffith region. The second one exists for all

H^i(\mu)

, and is similar to the

p

-filtration that has been considered by Jens Carsten Jantzen.

Résumé

Dans cet article, je prouverai l’existence de deux filtrations de la cohomologie des fibrés en droites sur

\operatorname{SL}_3/B

. La première est une filtration en deux étapes qui existe pour

H^1(\mu)

et

H^2(\mu)

si est dans la région de Griffith. La deuxième existe pour tous

H^i(\mu)

, et est similaire à la

p

-filtration qui a été envisagée par Jens Carsten Jantzen.
GAMETOCYTE DYNAMICS AND THE EFFECTS OF AQUEOUS AND ETHANOLIC LEAF EXTRACTS OF Lophira Lanceolata IN MICE INFECTED WITH Plasmodium Bergei
Authors: Ezea OC , Nwachukwu MO , Nnodim N.N , Nwachukwu C.N , Ozioko K.U , AZORJI JOHNPAUL 
Published: January 2023

Resistance of human malaria parasites to existing chemotherapeutic drugs remains a global challenge to malaria control. This study was an evaluation of the gametocyte dynamics and the potential roles of aqueous and ethanolic leaf extracts of Lophira lanceolata in the transmission of Plasmodium parasites using mice experimentally infected with P.berghei as a model. A total of 192 experimental mice divided into 15 groups in a randomized block design and replicated four times with four mice in each group were used for this study. Thirty-six (36) mice were used for acute toxicity test, 32 mice each for curative antiplasmodial assay, prophylactic assay and gametocyte evaluation, and analyses. Experimental mice were inoculated intraperitoneally with standard inoculum of 1 x 107P.berghei parasitized red blood cells on first day (DO). Body weights of mice were taken using sensitive digital weighing balance. Blood sample was collected by cardiac puncture using sterile needle and 5ml syringe and preserved in ethylene diaminetetraacetic acid (EDTA) bottle. Haematological components were determined using an autohaematology analyzer SYSMEX KX21. Data analysis was done using student’s t-test and one way analysis of variance with multiple comparison tests. Phytochemical screening revealed the presence of phenols, terpenoids, tannins, saponins, alkaloids, flavonoids, steroids, oxalates and cardiac glycosides. The flavonoids had the largest concentrations of 388.24mg/ml, and 350.00mg/ml in ethanolic and aqueous extracts respectively. LD50 was found to be > 5000mg/kg body weight in both extracts. At > 100mg/kg body weight, infected treated mice experienced body weight increases while infected untreated mice experienced decreases in mean body weight from 23.33g to 20.08g (mean 10% weight loss). Aqueous and ethanolic leaf extracts produced variations in number of gametocyte from mice infected with P.berghei. On days 7, 14, 21, and 28, the mean gametocytes of the parasite in the control group were 18, 21, 22, and 20 respectively which were significantly (p < 0.05) higher compared with the mean gametocytes in the groups of mice treated with aqueous extract, ethanolic extract and chloroquine drugs. The dose level of 10mg/kg body weight of aqueous extract produced the mean gametocyte counts of 10, 10, 8 and 6 on days 7, 14, 21 and 28 respectively which were significantly (p < 0.05) lower than the mean gametocyte counts of the control
Pengaruh Pekerjaan dan Pendapatan Keluarga terhadap Keaktifan Ibu Balita di Posyandu Desa Waung Kecamatan Boyolangu Kabupaten Tulungagung Tahun 2021
Authors: Hanifa Ainun , Sari Anita Dwi Agustina 
Published: January 2023

Pendahuluan: Keaktifan ibu ke posyandu bisa dilihat dari kehadiran ibu balita ≥ 8 kali dalam 1 tahun. Program posyandu merupakan strategi pemerintah untuk menurunkan Angka Kematian Ibu (AKI), Angka Kematian Bayi (AKB) dan Angka Kelahiran. Keaktifan ibu pada posyandu akan berpengaruh pada keadaan status gizi anak balitanya karena ibu yang tidak aktif akan mengakibatkan munculnya masalah pada bayi balita khususnya berhubungan dengan gizi dan tumbuh kembang. Tujuan dari penelitian ini adalah mengetahui pengaruh pekerjaan dan pendapatan terhadap keaktifan ibu balita di posyandu. Metode: Jenis penelitian observasional dengan desain case control. Sampel yang diambil semua ibu balita yang berada di posyandu 2 Desa Waung Kecamatan Boyolangu Kabupaten Tulungagung sejumlah 40 orang. Hasil: Hasil uji statistik dengan chi square didapatkan nilai p 0,000 sehingga signifikan ada pengaruh pekerjaan terhadap keaktifan ibu balita. Kesimpulan: Hasil statistik chi square didapat nilai p 0,037 sehingga signifkan ada pengaruh pendapatan keluarga terhadap keaktifan ibu balita. Pekerjaan dan pendapatan keluarga pada ibu balita berpengaruh terhadap kekatifan ibu untuk datang ke posyandu.
Kata kunci: Pekerjaan, pendapatan keluarga, keaktifan.
Adiós a un Maestro
Authors: Piscoya Alejandro 
Published: January 2023

Hace unos meses, en el editorial del número previo(1) comentábamos que H. pylori (Hp) seguía manteniendo su vigencia, a pesar de los años transcurridos desde su descubrimiento y de la gran cantidad de investigación sobre sus características y su relación con el cáncer de estómago.
P53 Over Expression in Bladder Carcinoma
Authors: Afshan Sabeen , Zaib Laila , Sharif Sumera , Faridi Javeria , Habib Farzana , Aisha Akbar  
Published: January 2023

Objective: The purpose of this research was to find out how prevalent p53 overexpression is in bladder urothelial cancer.
Methodology:Â This descriptive, cross-sectional study was conducted in KRL Hospital Islamabad from April 2018 to October 2018. All patients with biopsy-proven urinary bladder cancer, irrespective of gender or age range, were included in the research. Non-probability, consecutive sampling technique was used.Â The immunohistochemical processing was completed, and the results for p53 expression (positive/negative) were interpreted by the consultant pathologist. SPSS version 22.0 was used for the statistical analysis. Quantitative information, such as the patient's age and length of illness, were displayed using the mean and standard deviation. The P value was less than 0.05, the result was declared significant.
Results: The participants in this study ranged in age from 15 to 70 years old, with a mean age of 47.39 Â± 10.26 years. The male to female ratio was 1.6:1 among these 74 patients, with 45 (60.81 percent) being male and 29 (39.19 percent) being female. Overexpression of p53 was found in 31 (41.89 percent) of bladder urothelial carcinoma cases.
Conclusion: This study concluded that the frequency of p53 overexpression in bladder urothelial carcinoma is very high.
Sensitivity analysis of control networks in terms of minimal detectable displacements
Authors: Książek Krzysztof , Łapiński Sławomir 
Published: January 2023

Sensitivity analysis is one aspect of the calculation process in displacement measurement. For this purpose, sensitivity measures are used in the form of minimal detectable displacements ( ), derived from the definition of minimal detectable bias ( ). Analyses were performed based on disturbing the parameter vector with the value (calculated from principal component analysis). Analyses were considered for displacements of the levelling network based on the global vector ( ). The calculations were conducted using the least squares adjustment with pseudo-random observations. The mean success rate ( ) was used to perform the detection analyses. The effectiveness of the global test agrees with the assumed power of the test. Local tests for a single point showed 48.6 % displacements of more than one point. It should be considered using another local test for the case of displacements of multiple points. This study concludes that in addition to the accuracy of the designed network points, the network configuration is also important in sensitivity analyses. The research shows that sensitivity analyses should be considered at the design stage of control networks, i.e. to determine at what level a given network is able to detect displacement.
A Pilot Study for Remote Evaluation of Upper Extremity Motor Function After Stroke: The Arm Capacity and Movement Test (ArmCAM)
Authors: Yang Chieh-ling , Simpson Lisa A. , Eng Janice J. 
Published: January 2023

Importance: A simple measure that can be administered remotely by means of videoconferencing is needed for telerehabilitation.
Objective: To develop a valid and reliable measure, the Arm Capacity and Movement Test (ArmCAM), that can be administered remotely by means of videoconferencing to evaluate upper extremity motor function poststroke.
Design: Cross-sectional.
Setting: Participants’ homes.
Participants: A sample of people with stroke (N = 31).
Outcomes and Measures: Test–retest and interrater reliabilities were assessed through intraclass correlation coefficients (ICCs), Cohen’s κ, standard error of measurement (SEM), and minimal detectable change (MDC). Interrater reliability validity was examined with Pearson and Spearman rank correlation coefficients.
Results: The ArmCAM (range = 0–30) consists of 10 items and takes 15 min to administer with no special equipment except for a computer and internet access. The ICCs for test–retest reliability and interrater reliability were .997 and .993, respectively. The SEM and MDC95 were 0.74 and 2.05 points, respectively. Individual items’ test–retest reliability and interrater levels of agreement ranged from .811 to .957 and from .475 to .842, respectively, as measured with Cohen’s κ. Correlations between the ArmCAM and the Rating of Everyday Arm-use in the Community and Home scale; the Stroke Impact Scale, hand function domain; the Fugl-Meyer Assessment for upper extremity; and the Action Research Arm Test were good to excellent.
Conclusions and Relevance: The ArmCAM has good reliability and validity. It is an easy-to-use assessment designed to be administered remotely by means of videoconferencing.
What This Article Adds: The ArmCAM is a psychometrically sound instrument that can be easily administered remotely by means of videoconferencing to evaluate upper extremity motor function after stroke.
Feasibility of Problem-Solving Training During Inpatient Rehabilitation in Patients With Stroke
Authors: Osborne Candice L. , Pool Courtney L. , Juengst Shannon B. 
Published: January 2023

Abstract
Importance: Stroke survivors report feeling unprepared to manage challenges that arise during the transition from hospital to home. Cultivating problem-solving skills before discharge may better prepare patients for the transition home.
Objective: To determine the feasibility of a protocol to deliver Problem-Solving Training (PST) to stroke survivors during inpatient rehabilitation to increase goal achievement.
Design: Single-group feasibility study.
Setting: Academic and county hospital inpatient rehabilitation units.
Participants: Adult patients with stroke and planned discharge home.
Intervention: Up to six PST sessions over 2 to 3 wk followed by 3 mo of mobile health boosters.
Results: Of 17 eligible participants, 15 consented and 11 completed three or more PST sessions. Six participants used electronic boosters, achieving at least one goal postdischarge. Participants reported high satisfaction with PST (Client Satisfaction Questionnaire–8 M score = 29.3, SD = 4.4; range = 8–32), moderate depression at baseline (eight-item Patient Health Questionnaire [PHQ–8] score, M = 11.0, SD = 6.1; range = 0–27), mild depression at 3 mo postdischarge (PHQ–8 score, M = 8.3, SD = 5.5), moderately high self-efficacy at baseline (General Self-Efficacy Scale [GSE] score, M = 31.1, SD = 7.3; range = 10–40), and a self-efficacy increase at 3 mo postdischarge (GSE score, M = 34.1, SD = 4.2).
Conclusions and Relevance: PST among patients with stroke during inpatient rehabilitation was feasible, and participants demonstrated improvements in clinical outcomes and goal attainment. Barriers to participation and adherence should be addressed in future studies.
What This Article Adds: Teaching patients problem-solving skills early after a stroke using a metacognitive strategy is feasible and may decrease depression and increase self-efficacy while fostering independent goal setting and problem solving.
Hyperglycemic crisis and Parkinson disease: A retrospective cohort study based on nationwide data
Authors: Chung Kun-Ming , Ho Chung-Han , Chen Yi-Chen , Hsu Chien-Chin , Lin Hung-Jung , Wang Jhi-Joung , Tsai Kang-Ting , Huang Chien-Cheng 
Published: January 2023

IntroductionHyperglycemic crisis episode (HCE) suggests a poor control of diabetes, which may increase the risk of Parkinson disease (PD). This study aimed to clarify this issue since literature remains unclear.Material and methodsPatients with diabetes with and without HCE matched at a 1:1 ratio by age, sex, and index date between 2000 and 2002 from the Taiwan National Health Insurance Research Database were identified for analyses. Comparison of PD between patients with diabetes with and without HCE was performed by follow-up until 2012. Independent predictors for PD were also investigated among all patients.ResultsA total of 10,056 patients with diabetes with HCE and an identical number of patients with diabetes without HCE were included in the study. The mean age and male ratio were 62.0 years and 52.1%, respectively in both cohorts. Patients with HCE were found to have higher prevalence rates of hypertension, renal disease, hyperlipidemia, mental disorder, chronic obstructive pulmonary disease, liver disease, and head injury than those without HCE. Patients with HCE for ≥3 times had a higher risk for PD (adjusted hazard ratio [AHR]: 1.27; 95% confidence interval [CI]: 1.05-1.54) compared to those without HCE; however, patients with HCE for 1 or 2 times were not at high risk. Older age except ≥85 years, hypertension, hyperlipidemia, and mental disorder were also independent predictors for PD.ConclusionsHCE for ≥3 times is associated with PD. Close follow-up in older patients with HCE as well as control of hypertension, hyperlipidemia, and mental disorder are warranted.