bluuebunny/crossref_metadata_2025_split huggingface dataset:
Seamguard Buttressing of the Staple Line During Laparoscopic Sleeve Gastrectomy Appears to Decrease the Incidence of Postoperative Bleeding, Leaks, and Re-operations. A Meta-Analysis of Non-Randomized Comparative Studies
Authors: Diab Abdul-Rahman Fadi , Alfieri Sarah , Doyle William , Koussayer Bilal , Docimo Salvatore , Sujka Joseph Adam , DuCoin Christopher Garnet 
Published: January 2023

Abstract
Leaks and bleeding are major acute postoperative complications following laparoscopic sleeve gastrectomy (LSG). Various staple line reinforcement (SLR) methods have been invented such as oversewing, omentopexy/gastropexy, gluing, and buttressing. However, many surgeons don’t use any type of reinforcement. On the other hand, surgeons who use a reinforcement method are often confused of what kind of reinforcement they should use. No robust and high-quality data supports the use of one reinforcement over the other, or even supports the use of reinforcement over no reinforcement. Therefore, SLR is a controversial topic that is worth our focus. The aim of this study is to compare the outcomes of LSG with versus without Seamguard buttressing of the staple line during LSG.
Formation of mixed-layer sulfide-hydroxide minerals from the Tochilinite-Valleriite group during experimental serpentinization of olivine
Authors: McCollom Thomas M. , Hoehler Tori , Fike David A. , Houghton Jennifer L. , Bell Aaron , Klein Frieder , Moskowitz Bruce , Solheid Peter 
Published: January 2023

Abstract
We report the formation of minerals from the tochilinite-valleriite group (TVG) during laboratory serpentinization experiments conducted at 300 and 328 °C. Minerals in the TVG are composed of a mixture of sulfide and hydroxide layers that can contain variable proportions of Fe, Mg, Cu, Ni, and other cations in both layers. Members of this group have been observed as accessory minerals in several serpentinites, and have also been observed in association with serpentine minerals in meteorites. To our knowledge, however, TVG minerals have not previously been identified as reaction products during laboratory simulation of serpentinization. The serpentinization experiments reacted olivine with artificial seawater containing 34S-labeled sulfate, with a small amount of solid FeS also added to the 300 °C experiment. In both experiments, the predominant reaction products were chrysotile serpentine, brucite, and magnetite. At 300 °C, these major products were accompanied by trace amounts of the Ni-bearing TVG member haapalaite, Ni,Fe-sulfide (likely pentlandite), and anhydrite. At 328 °C, valleriite occurs rather than haapalaite and the accompanying Ni,Fe-sulfide is proportionally more enriched in Ni. Reduction of sulfate by H2 produced during serpentinization evidently provided a source of reduced S that contributed to formation of the TVG minerals and Ni,Fe-sulfides. The results provide new constraints on the conditions that allow precipitation of tochilinite-valleriite group minerals in natural serpentinites.
Two discrete gold mineralization events recorded by hydrothermal xenotime and monazite, Xiaoqinling gold district, central China
Authors: Jian Wei , Mao Jingwen , Lehmann Bernd , Wu Shitou , Chen Lei , Song Shiwei , Xu Jiandong , Wang Peng , Liu Junchen 
Published: January 2023

Abstract
We present in situ LA-ICP-MS U-Pb dating of xenotime and monazite in assemblages with native gold and Au (Ag) tellurides from the Xiaoqinling lode gold district in central China. Composite xenotime and monazite grains formed through coupled dissolution-reprecipitation reactions reveal two discrete gold mineralization events. The first gold mineralization event, recorded by monazite (158.6 ± 3.3 Ma, Tera-Wasserburg lower intercept age) and xenotime cores (157.11 ± 0.83 Ma, weighted mean 206Pb/238U age), is characterized by the mineral assemblage of lingbaoite (AgTe3)-sylvanite ([Au,Ag]2Te4)-stützite (Ag5–xTe3)/native tellurium-sylvanite-stützite. The second gold mineralization event, recorded in the rims of xenotime (135.46 ± 0.93 Ma, weighted mean 206Pb/238U age), is characterized by the mineral assemblage of native gold-calaverite (AuTe2)-petzite (AuAg3Te2)-tellurobismuthite (Bi2Te3). Our study implies that the large-scale Jurassic mineralization event in eastern China, related to flat subduction of the paleo-Pacific plate beneath the eastern China continent, also caused widespread gold mineralization in the Qinling-Dabie Orogen, in addition to production of its world-class porphyry Mo deposits. The fact that only a few Jurassic gold mineralization ages have been reported before, may be due to the lack of suitable geochronometers to record the earlier Jurassic hydrothermal processes, which have been overprinted by the better-recognized Early Cretaceous gold mineralization event. This study also presents a rare example of xenotime compositional alterations and resetting of U-Pb ages induced by low to moderate salinity carbono-aqueous fluids at low temperatures. The textural relationships between gold minerals in contact with such composite xenotime crystals demonstrate that they could have precipitated before, coeval with, or after the dated domains. Since low to moderate salinity carbono-aqueous fluids are commonly involved in the formation of lode gold deposits, it is crucial to examine xenotime textures and recognize potential alteration textures before carrying out isotopic dating of xenotime collected from these deposits. Without prior compositional and textural characterization, attempts to date such composite crystals could yield mixed dates and meaningless ages.
CURIES: Compendium of uranium Raman and infrared experimental spectra
Authors: Spano Tyler L. , Olds Travis A. , McDonnell Marshall , Smith Robert , Niedziela Jennifer L. , Miskowiec Andrew , Kapsimalis Roger , Shields Ashley E. 
Published: January 2023

Abstract
Identification of radioactive materials is a critical goal of resource exploration, basic actinide science, and nuclear forensics, and we provide here new insights toward rapid, nondestructive analysis of uranium-containing minerals and technogenic phases. Raman and infrared spectroscopic data are powerful indicators of solid-phase U(VI) coordination chemistry. In addition, U(VI) minerals exhibit high chemical and structural diversity as artifacts of geochemical processes leading to ore formation. Spectral signals of axial UO22+ (U-Oyl) bond lengths and the influences of additional oxyanions on these values are well documented for uranium oxide and oxysalt minerals and technogenic phases. Additional insight regarding the underlying crystallographic structure and chemical composition of uranium materials can be extracted through a survey of all available Raman spectroscopic data for these phases. To this end, we have developed the Compendium of Uranium Raman and Infrared Experimental Spectra (CURIES). CURIES was compiled via a thorough review of literature and databases, and for mineral species that lack measured and recorded spectra, data were obtained either from museum and academic collections or by direct syntheses. Characteristic Raman spectroscopic features for subgroups of uranyl minerals within CURIES were elucidated using multivariate statistical analyses. In addition, average spectra for groups of uranyl minerals were determined, providing insight into common spectroscopic characteristics that are indicative of the structural origins from which they arise. As of publication, 275 mineral species and technogenic phases have been entered in CURIES, and of these, 83 phases have published spectra that have been included in the CURIES database. Data collection is ongoing, and we have triaged missing data sets to assess CURIES for completion and to identify mineral groups that lack representation and should therefore be prioritized for data acquisition and inclusion in the database.
Analysis of main influencing factors of energy dissipation and flow diversion effects of rough-strip energy dissipators in curved spillways based on Plackett–Burman design
Authors: Zhang Honghong , Mu Zhenwei , Fan Fan , Yao Li 
Published: January 2023

Abstract
Rough-strip energy dissipators (R-SEDs) at the bottom of spillway bends have energy dissipation and flow diversion effects on bend flow. In this paper, twelve Plackett-Burman tests were conducted. Energy dissipation rate and coefficient of variation of superelevation were used as evaluation indices. Influencing factors (i.e., relative height, height ratio, spacing, angle and thickness of R-SEDs as well as centerline radius, width, angle and bottom slope of the bend) of R-SEDs' energy dissipation and flow diversion effects were analyzed using Minitab 21.1 in combination with the entropy weight method and the TOPSIS method. Relative height of R-SED and bend angle were significant factors affecting energy dissipation effects; height ratio of R-SED and centerline radius of the bend were significant factors affecting flow diversion effects; the coefficient of variation of superelevation had a larger weight (0.549) than the energy dissipation rate (0.451), indicating that R-SEDs' flow diversion effects were larger than their energy dissipation effects; height ratio of R-SED, centerline radius of the bend and bend angle were significant factors affecting overall energy dissipation and flow diversion effects and selected as key factors for further steepest climbing tests and response surface design.
Modelling-based methodological approach to assess the effect of urbanization on hydrology and runoff water quality: a case of study for tropical and dry regions
Authors: Ferrans Pascual , Temprano Javier 
Published: January 2023

Abstract
It is necessary to have unified tools and methodologies for the correct understanding and quantification of urbanization effects on watershed hydrology. This study presents a modelling-based methodology developed on EPA SWMM to evaluate the effect of urbanization in conceptual watersheds using meteorological data from cities in Spain and Colombia. Results show that the effect of urbanization is significant in variables such as runoff volume, peak flow and pollutant loads, increasing these indicators in all cases. Furthermore, this effect has different dynamics for the regions evaluated. Overall, Colombian cities presented higher runoff volumes, peak flows and pollutant loads, while Spanish cities presented higher variability in these variables due to urbanization. The analysis allowed to cluster the cities within each country, using as criteria the modelled hydrological behaviour. A curve fitting procedure presented high performance rates for all the variables studied.
The Potential of Melatonin to Treat Atherosclerosis by Targeting Mitochondria
Authors: Sun Xuan , Chen Li , Gui Qing-Jun 
Published: January 2023

Abstract:As a circadian rhythm hormone, melatonin is widely present in the body and has rich physiological functions. Compared to its prominent circadian role, melatonin has been extensively studied in many fields as an ancient antioxidant. In addition to being considered a potent antioxi-dant, melatonin has also been found to play an important role in mitochondrial homeostasis. Mito-chondrial oxidative stress plays a crucial role in the occurrence and development of atherosclerosis. Therefore, the possible therapeutic value of melatonin as an antioxidant targeting mitochondria in atherosclerosis is worth exploring. The most widespread clinical applications of melatonin are in circadian rhythms and sleep, but the cardiovascular system may be the most promising area.
Impacts of Plant-derived Secondary Metabolites for Improving Flora in
Type 2 Diabetes
Authors: Li Lin Zehao , Yan Yan , Song Qinghe , Wang Zhibin , Zhang Wei , Hou Yanli , Zhang Xiandang 
Published: January 2023

Background:
Diabetes has become a problem that plagues public healthcare systems.
Recent studies have shown that intestinal flora exerts positive therapeutic effects on metabolic diseases,
and plant-derived secondary metabolites are safe, effective and easy to prepare and also have
an impact on intestinal flora and diabetes; these drugs have rarely been reviewed before as a class
of drugs for diabetes, especially focusing on the intestinal flora. Therefore, studying the relationship
between plant-derived secondary metabolites and diabetes mellitus is crucial.

Objective:
The objective of this study is to summarize and investigate the therapeutic mechanism
of drugs extracted from natural plants effects on type 2 diabetes mellitus.

Methods:
The relationship between flora and type 2 diabetes was investigated by reviewing the recent
experimental literature, and the pathways available for natural plant-derived secondary metabolites
in the treatment of type 2 diabetes were summarized.

Results:
The therapeutic mechanisms of common plant-derived secondary metabolites for type 2
diabetes were summarized with a focus on the prebiotic efficacy of natural plant-derived secondary
metabolites and the modulation of intestinal flora, and the mechanisms through which plantderived
secondary metabolites treat type 2 diabetes via effects on intestinal flora are further reviewed.

Conclusion:
Common plant-derived secondary metabolites can play a role in regulating bacteria in
the intestinal tract by enriching beneficial bacteria and removing harmful bacteria to achieve their
therapeutic effect on type 2 diabetes. In addition, due to their excellent ability to regulate intestinal
flora, plant-derived secondary metabolites may also have excellent efficacy in cancer and obesity,
among other diseases.
Ginsenoside Rb1 Suppresses AOM/DSS-induced Colon Carcinogenesis
Authors: Wang Ling , Zhang Qing-Qing , Xu Yu-Yu , Zhang Rui , Zhao Qing , Zhang Yu-Qing , Huang Xue-Hong , Jiang Bin , Ni Min 
Published: January 2023

Background:
Colorectal cancer (CRC) is the third most common cancer worldwide. Current treatments, including
surgery, radiotherapy, and chemotherapy, are limited by severe side effects and the development of resistance.

Objective:
Therefore, it is important to find additional therapies to combat the problem. Ginsenoside Rb1 is the main
active ingredient of ginseng, which is a well-known herb in traditional Chinese medicine. Ginsenoside is reported to
play an important role in the prevention and treatment of cancer.

Methods:
We established Azoxymethane (AOM)/Dextran sodium sulfate (DSS) colon cancer model based on inflammation,
observed the beneficial effect of ginsenoside Rb1, and detected the changes in gut microbiota.

Results:
Our experimental results showed that ginsenoside Rb1 significantly reduced the levels of TNF-α, IL-6, IL-
17A, IL-33, IL-1β, and IL-22, increased the level of IL-10, and also changed the gut microbiota composition. These
results suggested that ginsenoside Rb1 can be used to prevent inflammation-associated CRC development and may
provide an effective therapeutic strategy for CRC by relieving chronic inflammation and restoring the gut microenvironment
in the AOM/DSS-induced model of colitis-associated colorectal cancer in mice.

Conclusion:
Ginsenoside Rb1 significantly attenuated AOM/DSS-induced colon carcinogenesis.
Biodegradable Polymer-Based Microspheres for Depot Injection-Industry
Perception
Authors: Kyatanwar Anand , Nagarsenker Mangal , Prabhakar Bala 
Published: January 2023

Abstract:
The discovery of proteins and peptides marked the actual beginning for pharmaceutical
companies to do research on novel delivery systems for delivering these therapeutic proteins. Biodegradable
polymer-based microspheres for controlled-release depot injection are known for decades
and have proved to be one of the best possible approaches. Despite being known for decades, the
commercial success of microsphere-based delivery systems remains limited. Very few products are
seen in the market with no generics available for approved brand products whose patents have either
expired or are about to expire. All this points to the complexities involved in developing these delivery
systems. Still, many hurdles remain in developing these drug delivery systems namely, poor drug entrapment,
unwanted burst release, poor in vitro in vivo correlation, lack of proper in vitro testing
methods, problems involved during scale-up, and the most important hurdle being sterilization of the
product. To achieve successful product development, all of these technical difficulties need to be simultaneously
dealt with and resolved. This article attempts to highlight the problem areas for these delivery
systems along with the regulatory requirements involved and map the present status of these delivery
systems.
Provider Perspectives on Artificial Intelligence–Guided Screening for Low Ejection Fraction in Primary Care: Qualitative Study
Authors: Barry Barbara , Zhu Xuan , Behnken Emma , Inselman Jonathan , Schaepe Karen , McCoy Rozalina , Rushlow David , Noseworthy Peter , Richardson Jordan , Curtis Susan , Sharp Richard , Misra Artika , Akfaly Abdulla , Molling Paul , Bernard Matthew , Yao Xiaoxi 
Published: January 2023

Background
The promise of artificial intelligence (AI) to transform health care is threatened by a tangle of challenges that emerge as new AI tools are introduced into clinical practice. AI tools with high accuracy, especially those that detect asymptomatic cases, may be hindered by barriers to adoption. Understanding provider needs and concerns is critical to inform implementation strategies that improve provider buy-in and adoption of AI tools in medicine.

Objective
This study aimed to describe provider perspectives on the adoption of an AI-enabled screening tool in primary care to inform effective integration and sustained use.

Methods
A qualitative study was conducted between December 2019 and February 2020 as part of a pragmatic randomized controlled trial at a large academic medical center in the United States. In all, 29 primary care providers were purposively sampled using a positive deviance approach for participation in semistructured focus groups after their use of the AI tool in the randomized controlled trial was complete. Focus group data were analyzed using a grounded theory approach; iterative analysis was conducted to identify codes and themes, which were synthesized into findings.

Results
Our findings revealed that providers understood the purpose and functionality of the AI tool and saw potential value for more accurate and faster diagnoses. However, successful adoption into routine patient care requires the smooth integration of the tool with clinical decision-making and existing workflow to address provider needs and preferences during implementation. To fulfill the AI tool’s promise of clinical value, providers identified areas for improvement including integration with clinical decision-making, cost-effectiveness and resource allocation, provider training, workflow integration, care pathway coordination, and provider-patient communication.

Conclusions
The implementation of AI-enabled tools in medicine can benefit from sensitivity to the nuanced context of care and provider needs to enable the useful adoption of AI tools at the point of care.

Trial Registration
ClinicalTrials.gov NCT04000087; https://clinicaltrials.gov/ct2/show/NCT04000087
Effects of Fetal Images Produced in Virtual Reality on Maternal-Fetal Attachment: Randomized Controlled Trial
Authors: Lee Kyong-No , Kim Hyeon Ji , Choe Kiroong , Cho Aeri , Kim Bohyoung , Seo Jinwook , Myung Woojae , Park Jee Yoon , Oh Kyung Joon 
Published: January 2023

Background
Maternal-fetal attachment (MFA) has been reported to be associated with the postpartum mother-infant relationship. Seeing the fetus through ultrasound might influence MFA, and the effect could be increased by more realistic images, such as those generated in virtual reality (VR).

Objective
The aim was to determine the effect of fetal images generated in VR on MFA and depressive symptoms through a prenatal-coaching mobile app.

Methods
This 2-arm parallel randomized controlled trial involved a total of 80 pregnant women. Eligible women were randomly assigned to either a mobile app–only group (n=40) or an app plus VR group (n=40). The VR group experienced their own baby’s images generated in VR based on images obtained from fetal ultrasonography. The prenatal-coaching mobile app recommended health behavior for the pregnant women according to gestational age, provided feedback on entered data for maternal weight, blood pressure, and glucose levels, and included a private diary service for fetal ultrasound images. Both groups received the same app, but the VR group also viewed fetal images produced in VR; these images were stored in the app. All participants filled out questionnaires to assess MFA, depressive symptoms, and other basic medical information. The questionnaires were filled out again after the interventions.

Results
Basic demographic data were comparable between the 2 groups. Most of the assessments showed comparable results for the 2 groups, but the mean score to assess interaction with the fetus was significantly higher for the VR group than the control group (0.4 vs 0.1, P=.004). The proportion of participants with an increased score for this category after the intervention was significantly higher in the VR group than the control group (43% vs 13%, P=.005). The feedback questionnaire revealed that scores for the degree of perception of fetal appearance all increased after the intervention in the VR group.

Conclusions
The use of a mobile app with fetal images in VR significantly increased maternal interaction with the fetus.

Trial Registration
ClinicalTrials.gov NCT04942197; https://clinicaltrials.gov/ct2/show/NCT04942197
Formulation and Evaluation of a Turmeric Kombucha Facial Toner with Potential as an Anti-Acne Agent
Authors: Muhsinin Soni , Salsabilla Dini Zamzami , Mardhiani Yanni Dhiani , Jafar Garnadi 
Published: January 2023

Propionibacterium acnes is one of the gram-positive bacteria that causes acne. Many acne treatments use synthetic drugs that have side effects. One alternative for treatment is using fermented products such as kombucha. The potential of kombucha as an anti-acne can be increased by adding turmeric during the fermentation process. The product is Turmeric Kombucha, which will be applied to the skin. The cosmetic dosage form developed is Facial Toner. The research to be carried out aims to formulate and test the activity of turmeric kombucha facial toner preparations against P.acnes bacteria. The novelties of this research include increasing the anti-acne activity of Turmeric Kombucha and the addition of Turmeric Kombucha as an active ingredient in facial toner preparations that meet the evaluation requirements, activity tests, and stability tests. The stages of the method started with Turmeric Kombucha fermentation with variations in turmeric concentration and fermentation time. The fermentation results will be tested for antibacterial activity using the paper disc diffusion method. Turmeric Kombucha, which has the highest activity, is then used as an active substance in facial toner preparations, which will be evaluated and tested for stability. The results of the evaluation of facial toner preparations, all formulas meet the requirements for organoleptic, pH, and viscosity tests. The stability test results for facial toner preparations show that F3 is a stable formula at room temperature storage and extreme temperatures. Based on the results of the irritation test, kombucha turmeric facial toner did not irritate. The antibacterial test results showed that all formulas could inhibit P.acnes bacteria with F3 as the formula with the most effective inhibition diameter of 7.33 ± 0.57 mm, then F1 and F4 6.33 ± 0.57 mm, and F2 6 ± 0 mm. This study concludes that fermented turmeric kombucha can be formulated as an anti-acne facial toner.
Keywords: paper disc diffusion, Propionibacterium acnes, facial toner, Turmeric Kombucha