bluuebunny/crossref_metadata_2025_split huggingface dataset:
Giant left atrial myxoma causing mitral regurgitation through annulus dilatation
Authors: Xu Danfeng , Li Xuejie 
Published: July 2023

Key Clinical MessageGiant left atrial myxoma causing mitral regurgitation through mitral annulus dilatation without affecting leaflet function is rarely reported.AbstractThis is a case of a 37‐year‐old man suffering from worsening exertional dyspnea detected left atrial myxoma 92 × 43 mm. Radical mass resection and mitral annuloplasty were performed simultaneously. Giant left atrial myxoma causing mitral regurgitation through mitral annulus dilatation without affecting leaflet function is rarely reported.
The Role of Inverted Ligand Field in the Electronic Structure and Reactivity of Octahedral Formal Platinum (IV) Complexes**
Authors: Ienco Andrea , Ruffo Francesco , Manca Gabriele 
Published: July 2023

AbstractPlatinum complexes are ubiquitous in chemistry and largely used as catalysts or as precursors in drug chemistry, thus a deep knowledge of their electronic properties may help in planning new synthetic strategies or exploring new potential applications. Herein, the electronic structure of many octahedral platinum complexes is drastically revised especially when they feature electronegative elements such as halogens and chalcogens. The investigation revealed that in most cases the five d platinum orbitals are invariably full, thus the empty antibonding orbitals, usually localized on the metal, are mainly centered on the ligands, suggesting a questionable assignment of formal oxidation state IV. The analysis supports the occurrence of the inverted ligand field theory in all cases with the only exceptions of the Pt−F and Pt−O bonding. The trends for the molecular complexes are mirrored also by the density of states plots of extended structures featuring octahedral platinum moieties in association with chalcogens atoms. Finally, the oxidative addition of a Se−Cl linkage to a square platinum complex to achieve an octahedral moiety has been revised in the framework of the inverted ligand field.
Reduced Tiara‐like Palladium Complex for Suzuki Cross‐Coupling Reactions
Authors: Daka Mario , Montini Tiziano , Pengo Paolo , Marussi Giovanna , Crosera Matteo , Adami Gianpiero , Delgado Juan Jose , Giambastiani Giuliano , Fertey Pierre , Fonda Emiliano , Pasquato Lucia , Fornasiero Paolo 
Published: July 2023

AbstractThe design of highly active and structurally well‐defined catalysts has become a crucial issue for heterogeneous catalysed reactions while reducing the amount of catalyst employed. Beside conventional synthetic routes, the employment of polynuclear transition metal complexes as catalysts or catalyst precursors has progressively intercepted a growing interest. These well‐defined species promise to deliver catalytic systems where a strict control on the nuclearity allows to improve the catalytic performance while reducing the active phase loading. This study describes the development of a highly active and reusable palladium‐based catalyst on alumina (Pd8/Al2O3) for Suzuki cross‐coupling reactions. An octanuclear tiara‐like palladium complex was selected as active phase precursor to give isolated Pd‐clusters of ca. 1 nm in size on Al2O3. The catalyst was thoroughly characterised by several complementary techniques to assess its structural and chemical nature. The high specific activity of the catalyst has allowed to carry out the cross‐coupling reaction in 30 min using only 0.12 mol % of Pd loading under very mild and green reaction conditions. Screening of various substrates and selectivity tests, combined with recycling and benchmarking experiments, have been used to highlight the great potentialities of this new Pd8/Al2O3 catalyst.
[(μ3‐F)(BrF5)3]− – An Unprecedented Molecular Fluoridobromate(V) Anion in Cs[Br3F16]
Authors: Möbs Martin , Graubner Tim , Karttunen Antti J. , Kraus Florian 
Published: July 2023

AbstractThe reaction of Cs[BrF6] with BrF5 gave the compound Cs[Br3F16] with the unprecedented propeller‐shaped, C3‐symmetric [(μ3‐F)(BrF5)3]− anion. All other currently known fluoridobromates(V) contain only octahedral [BrF6]− anions, which, unlike the related [IF6]− anions, never exhibited stereochemical activity of the lone pair on the Br atoms. Despite the same coordination number of six for the Br atom in the [BrF6]− and [(μ3‐F)(BrF5)3]− anions, the longer μ3‐F−Br bonds provide additional space, allowing the lone pairs on the Br atoms to become stereochemically active. Cs[Br3F16] was characterized by single‐crystal X‐ray diffraction, Raman spectroscopy, and quantum‐chemical calculations for both the solid‐state compound and the isolated anion at 0 K. Intrinsic bond orbital calculations show that the μ3‐F−Br bond is essentially ionic in nature and also underpin the stereochemical activity of the lone pairs of the Br(V) atoms.
Erythronium Bonds: Noncovalent Interactions Involving Group 5 Elements as Electron‐Density Acceptors**
Authors: Calabrese Miriam , Gomila Rosa M. , Pizzi Andrea , Frontera Antonio , Resnati Giuseppe 
Published: July 2023

AbstractAnalyses of the Cambridge Structural Database and theoretical calculations (PBE0‐D3/def2‐TZVP level, atoms‐in‐molecules, natural bond orbital studies) prove the formation of net attractive noncovalent interactions between group 5 elements and electron‐rich atoms (neutral or anionic). These kinds of bonding are markedly different from coordination bonds formed by the same elements and possess the distinctive features of σ‐hole interactions. The term erythronium bond is proposed to denote these bonds. X‐ray structures of vanadate‐dependent bromoperoxidases show that these interactions are present also in biological systems.
Chiroptical Generation, Switching, and Long‐Term Memory in Supramolecular Azobenzene‐Pendant Polymer: Regulation by Cellulose Peralkyl Esters, D‐/L‐Glucose Permethyl Esters, Solvents, UV Light Irradiation, and Thermal Annealing Process†
Authors: Yi Shiyuan , Wang Laibing , Cheng Xiaoxiao , Fujiki Michiya , Zhang Wei 
Published: July 2023

Comprehensive SummaryVarious optically active polymers are known to afford sophisticated chirality‐related functionalities, i.e., asymmetric catalysis, chiroptical switching and memory in UV‐vis‐NIR region, chromatographic separation of enantiomers, and sensors for molecular chirality. Recently, material researchers have paid much attention to the design of chiral supramolecular architectures from achiral polymers upon intermolecular interactions with help of greener biosources. The present article reports an instantaneous generation of ambidextrous supramolecules revealing light‐driven chiroptical switching/memory in UV‐vis region when achiral azobenzene‐containing vinylpolymers are non‐covalently interacted with alkyl ester derivatives of natural cellulose and D‐/L‐glucose. It was recognized that the semi‐synthetic biomaterials efficiently work as chirality‐inducing scaffoldings to several achiral and optically inactive molecules, oligomers, and polymers. Our successful results shed light on a new approach of how inexpensive poly‐/mono‐saccharide derivatives can afford supramolecular chiroptical systems with the azobenzene pendant polymer as aggregates in suspension and liquid‐crystalline films with minimal energy, time, and cost.
Safety and efficacy of ablation for atrial fibrillation in combination with left atrial appendage occlusion in octogenarians
Authors: Zhang Peng‐Pai , Zhao Yan , Sun Jian , Wang Qun‐Shan , Li Wei , Zhang Rui , Chen Mu , Mo Bin‐Feng , Yu Yi , Feng Xiang‐Fei , Liu Bo , Yu Yi‐Chi , Lu Qiu‐Fen , Li Yi‐Gang 
Published: July 2023

AbstractBackgroundCatheter ablation (CA) combined with left atrial appendage occlusion (LAAO) is a feasible approach for atrial fibrillation (AF) patients. Its role in octogenarians with AF is unclear.HypothesisIn AF patients over 80 years, CA combined with LAAO is a feasible way in restoring sinus rhythm and preventing stroke.MethodsThis is a single‐center retrospective study. Patients who underwent CA and LAAO in a single procedure between March 2018 and December 2020 were included. Efficacy endpoints included procedural success rate, AF recurrence rate, and thromboembolic events. Safety endpoints included pericardial effusion/cardiac tamponade, device‐related thrombus (DRT), all‐cause death, and major bleeding.ResultsFive hundred and five patients (mean age 69.5 ± 7.7 years; 230 [45.5%] female) were included, with 46 (9.1%) patients aged ≥80 years old (octogenarian group). Prevalence of paroxysmal AF (25 [54.3%] vs. 207 [45.1%], p < 0.001) and CHA2DS2VASc score (4.1 ± 1.3 vs. 3.1 ± 1.4, p < 0.0001) were higher in octogenarian patients. There were six cases (1.2%) of pericardial effusion (all in nonoctogenarian patients). At 3 months postprocedure, 437 patients underwent TEE/CT. Thirty‐two (80%) octogenarian patients and 308 (77.6%) nonoctogenarian patients had no peri‐device leak. After a mean follow‐up of 26.9 ± 9.1 months, AF was documented in 10 (21.7%) patients in octogenarian group and in 103 (22.4%) patients in nonoctogenarian group (p = 0.99). The annual thromboembolic risk was 2.1% and 0.8% in the octogenarian group and nonoctogenarian group, respectively. Death occurred in 16 nonoctogenarian patients. One major bleeding was recorded in the octogenarian group.ConclusionsThe combination of CA and LAAO in a single procedure is a feasible treatment option in octogenarians with comparable efficacy and safety profile.
Development and validation of a prediction model based on machine learning algorithms for predicting the risk of heart failure in middle‐aged and older US people with prediabetes or diabetes
Authors: Wang Yicheng , Hou Riting , Ni Binghang , Jiang Yu , Zhang Yan 
Published: July 2023

AbstractBackgroundThe purpose of this study was to develop and validate a machine learning (ML) based prediction model for the risk of heart failure (HF) in patients with prediabetes or diabetes.MethodsWe used 3527 subjects aged 40 years and older with a prior diagnosis of prediabetes or diabetes from the National Health and Nutrition Examination Survey (NHANES) from 2007 to 2018. The search for independent risk variables linked to HF was conducted using univariate and multivariable logistic regression analysis. The 3527 subjects were randomly divided into training set and validation set in a 7:3 ratio. Five ML models were built on the training set using five ML algorithms, including random forest (RF), and then validated on the validation set. Receiver operating characteristic (ROC) curves, calibration curves, and decision curve analysis and Bootstrap resampling method were used to measure the predictive performance of the five ML models.ResultsMultivariate logistic regression analysis showed that age, poverty‐to‐income ratio, myocardial infarction condition, coronary heart disease condition, chest pain condition, and glucose‐lowering medication use were independent predictors of HF. By comparing the performance of the five ML models, the RF model (AUC = 0.978) was the best prediction model.ConclusionsThe risk of HF in middle‐aged and elderly patients with prediabetes or diabetes can be accurately predicted using ML models. The best prediction performance is presented by RF model, which can assist doctors in making clinical decisions.
Prioritizing parotid gland surgery: A call for the implementation of the MSRSGC classification
Authors: Reerds Sam T. H. , Honings Jimmie , van Engen Adriana C. H. , Marres Henri A. M. , Takes Robert P. , van den Hoogen Frank J. A. 
Published: July 2023

AbstractBackgroundThe Milan System for Reporting Salivary Gland Cytopathology (MSRSGC) is developed to aid diagnosis and management of salivary gland tumors. This study evaluates the time‐to‐treatment initiation (TTI) for parotid gland tumors in the Netherlands and relates these to the MSRSGC classification. Subsequently, the use of the MSRSGC in the Netherlands is evaluated.MethodsData regarding fine‐needle aspiration cytology (FNAC) and histopathological resections of the parotid were gathered from the Dutch nationwide pathology data bank (PALGA). The TTI was calculated for each MSRSGC category and type of treating center. FNACs performed from 2018 to 2021 were gathered from PALGA to estimate how frequently the MSRSGC classification was applied.ResultsMedian TTI in days were 86 for nondiagnostic (MSRSGC I), 75 for nonneoplastic (MSRSGC II), 65 for atypia of unknown significance (AUS) (MSRSGC III), 89 for benign (MSRSGC IVa), 52 for salivary gland neoplasm of unknown malignant potential (SUMP) (MSRSGC IVb), 31 for suspected malignant (MSRSGC V), and 30 for malignant (MSRSGC VI) categories. Significant variation in the TTI between the types of treating centers was found for the nondiagnostic, nonneoplastic, AUS, SUMP, and suspected malignant categories. In the first 3 years after the introduction of the MSRSGC, the pathologist stated the MSRSGC classification in 6.4% of all reports.ConclusionsThe median TTI for most categories is long, and there is significant interhospital variation in TTI. Preoperative risk stratification and treatment prioritization in parotid gland surgery in the Netherlands should be improved. The MSRSGC could contribute to this. Until 2021, the MSRSGS classification was implemented on a limited scale in the Netherlands.
Predictors of psychotherapy dropout in patients with borderline personality disorder: A systematic review
Authors: de Freixo Ferreira Leonor , Guerra Cátia , Vieira‐Coelho M. A. 
Published: July 2023

AbstractIntroductionBorderline personality disorder (BPD) is a highly debilitating psychiatric condition. Despite the expansion of new BPD specific forms of psychotherapy in the last few decades, high dropout rates have been reported in these treatments. Treatment discontinuation is associated with poor patient outcomes, inefficient resource utilization and the demoralization of healthcare providers.MethodsIn order to identify predictors of psychotherapy dropout among patients with BPD, a systematic search of Medline, the Cochrane Library, PsycInfo and PsycArticles was conducted. Studies included were randomized‐controlled trials in which patients diagnosed with BPD were exposed to a therapeutic intervention consisted of an evidence‐based psychotherapy. The quality of evidence in the studies was assessed through the use of revised Cochrane risk of bias tool.ResultsSix articles, incorporating four types of psychotherapy programmes, were included. Overall, the studies present low risk of attrition and reporting bias and unclear risk of selection, performance and detection bias. Patients with weaker therapeutic alliance scores and higher hostility presented with higher dropout rates. In contrast, better mindfulness skills and greater performance in specific neuropsychological domains, such as memory and executive control, were identified as predictive of lower risk of dropout. Sociodemographic variables and treatment history did not influence treatment retention.ConclusionsFactors that influence discontinuation should be taken into consideration in future treatment programmes, in an effort to optimize retention. Qualitative assessments of patients' reasons for dropping out may also help guide adjustments.
Reliability evaluation of carrier‐based pulse width modulated three‐level F‐type neutral point clamped inverter with power loss analysis
Authors: Roy Priyankar , Kurre Manish , Charan Nannam Hari , Banerjee Atanu 
Published: July 2023

AbstractAn improved carrier‐based pulse‐width‐modulation (CBPWM) technique for a three‐level (3L) F‐type neutral point‐clamped (FNPC) inverter is presented in this paper. By using the proposed modulation scheme, the DC‐link capacitor voltage at the neutral point is balanced. For manufacturers, reliability is one of the major concerns for all power electronics devices and parts. This paper proposes an extensive reliability analysis of the 3L‐FNPC inverter. Considering the mean time to failure (MTTF) of each device, the reliability of the 3L‐FNPC inverter is analyzed in this present work by using two different methods, which are the approximate method and the exact method. To compute the failure rate of the equipment, only the number of components is considered in the approximate method. Alternatively, exact methods are utilized to evaluate the reliability of a system by knowing the different stress levels and various operating environments of a specific system. Because of the strong correlation between device failure and temperature stress factors, power loss analysis is used in the exact method. The MATLAB Simulink environment is used to determine the power loss of the switching devices. A solar off‐grid photovoltaic (PV) system is considered for reliability testing. Experimental mission profile data are used to estimate the lifetime of the 3L‐FNPC inverter by applying the rainflow counting algorithm, the Coffin‐Manson model, and Miner's rule. The competitiveness, effectiveness, and reliability of the 3L‐FNPC inverter with the proposed modulation technique are validated using a hardware prototype.
Plasma‐derived biomarkers of Alzheimer's disease and neuropsychiatric symptoms: A community‐based study
Authors: Krell‐Roesch Janina , Zaniletti Isabella , Syrjanen Jeremy A. , Kremers Walter K. , Algeciras‐Schimnich Alicia , Dage Jeffrey L. , van Harten Argonde C. , Fields Julie A. , Knopman David S. , Jack Clifford R. , Petersen Ronald C. , Vassilaki Maria , Geda Yonas E. 
Published: July 2023

AbstractINTRODUCTIONWe examined associations between plasma‐derived biomarkers of Alzheimer's disease (AD) and neuropsychiatric symptoms (NPS) in community‐dwelling older adults.METHODSCross‐sectional study involving 1005 persons ≥50 years of age (mean 74 years, 564 male, 118 cognitively impaired), who completed plasma‐derived biomarker (amyloid beta 42 [Aβ42]/Aβ40, phosphorylated tau 181 [p‐tau181], p‐tau217, total tau [t‐tau], neurofilament light [NfL]), and NPS assessment.RESULTSP‐tau181 (odds ratio [OR] 2.06, 95% confidence interval [CI] 1.41–3.00, p < 0.001), p‐tau217 (OR 1.70, 95% CI 1.10–2.61, p = 0.016), and t‐tau (OR 1.44, 95% CI 1.08–1.92, p = 0.012) were associated with appetite change. We also found that p‐tau181 and p‐tau217 were associated with increased symptoms of agitation (OR 1.93, 95% CI 1.20–3.11, p = 0.007 and OR 2.04, 95% CI 1.21–3.42, p = 0.007, respectively), and disinhibition (OR 2.39, 95% CI 1.45–3.93, p = 0.001 and OR 2.30, 95% CI 1.33–3.98, p = 0.003, respectively). Aβ42/Aβ40 and NfL were not associated with NPS.CONCLUSIONHigher plasma‐derived p‐tau181 and p‐tau217 levels are associated with increased symptoms of appetite change, agitation, and disinhibition. These findings may support the validity of plasma tau biomarkers for predicting behavioral symptoms that often accompany cognitive impairment.HIGHLIGHTS
We studied 1005 community‐dwelling persons aged ≥ 50 years
Higher plasma tau levels are associated with increased neuropsychiatric symptoms
Aβ42/Aβ40 and NfL are not associated with neuropsychiatric symptoms
Clinicians should treat neuropsychiatric symptoms in persons with high plasma‐derived tau
Admission hyponatraemia as heart failure events predictor in patients with acute heart failure
Authors: Sarastri Yuke , Zebua Juang Idaman , Lubis Puja Nastia , Zahra Fathi , Lubis Anggia Chairuddin 
Published: July 2023

AbstractAimsHeart failure remained consistent as one of the biggest cardiovascular problems in Indonesia. Hyponatraemia is a common electrolyte disorder among patients presented with heart failure; however, the prognostic value for worsening heart failure has not been well defined.Methods and resultsWe studied 134 patients admitted with acute heart failure and investigated the relationship between admission serum sodium and the composite clinical outcomes of all‐cause mortality and hospitalization ambispectively with a follow‐up duration of 6 months. We also try to look for low sodium‐level impacts in several conditions. Among 134 patients, 84 patients presented with low sodium during admission, defined as a serum sodium level of <135 mEq/L, and it was associated with higher composite clinical outcome risk [odds ratio (OR), 5.9; 95% confidence interval (CI), 2.8–12.0; P < 0.001]. Moreover, hyponatraemia impacts on composite endpoints were driven by both parameters; it was independently associated with mortality (OR, 3.1; 95% CI, 1.4–6.8; P = 0.003) and rehospitalization (OR, 5.3; 95% CI, 2.4–11.7; P < 0.001). This result remained consistent in most subgroups.ConclusionsOn‐admission hyponatraemia is a predictor for 6 month mortality and rehospitalization. Further work is needed to determine if correction of hyponatraemia translates into clinical benefit.
Efficacy and safety of baroreflex activation therapy for heart failure with reduced ejection fraction: systematic review
Authors: Molina‐Linde Juan Máximo , Cordero‐Pereda David , Baños‐Álvarez Elena , Rosario‐Lozano Maria Piedad , Blasco‐Amaro Juan Antonio 
Published: July 2023

AbstractBaroreflex activation therapy (BAT) is a possible adjuvant treatment for patients with heart failure with reduced ejection fraction (HFrEF) who remain symptomatic despite optimal medical therapy and may be an alternative therapy in patients with contraindications or drug intolerance. Our aim was to evaluate the efficacy and safety of BAT in patients with HFrEF. The protocol for this study was registered with PROSPERO (CRD42022349175). Searches were conducted using MEDLINE, preMedLine (via PubMed), EMBASE, Cochrane Library, Web of Science, Trip Medical Database, WHO International Clinical Trials Registry, and ClinicalTrials.gov. We included randomized controlled trials that compared the effects of BAT with pharmacological treatment. We assessed the risk of bias of each study using the Cochrane RoB2 tool and the certainty of the results using the GRADE approach. We performed a meta‐analysis of treatment effects using a fixed‐effects or random‐effects model, depending on the heterogeneity observed. Two studies were included in the meta‐analysis (HOPE4HF and BeAT‐HF). The results showed that BAT led to statistically significant improvements in New York Heart Association functional class (relative risk 2.13; 95% confidence interval [CI, 1.65 to 2.76]), quality of life (difference in means −16.97; 95% CI [−21.87 to −12.07]), 6 min walk test (difference in means 56.54; 95% CI [55.67 to 57.41]) and N‐terminal probrain natriuretic peptide (difference in means −120.02; 95% CI [−193.58 to −46.45]). The system‐ and procedure‐related complication event‐free rate varied from 85.9% to 97%. The results show that BAT is safe and improves functional class, quality of life and congestion in selected patients with HFrEF. Further studies and long‐term follow‐up are needed to assess efficacy in reducing cardiovascular events and mortality.