bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multidisciplinary team meeting in the core of nasopharyngeal cancer management improved quality of care and survival of patients
Authors: Taroeno-Hariadi Kartika W. , Herdini Camelia , Briliant Aulia S. , Kusumo Henry , Dhamiyati Wigati , Indrasari Sagung Rai , Lestari Setiyani P. , Widyastuti Yulestrina , Puspitaningtyas Herindita , Rahmasari Risa , Rachmawati Innayah Nur , Purwanto Ibnu , Setiawan Nurhuda H , Ekaputra Ericko , Hutajulu Susanna H. , Dwidanarti Sri R. , Kurniawan Torana , Meidania Lidya , Yanuarta Seize E. , Hardianti Mardiah S. , Kurnianda Johan 
Published: January 2023

Abstract

Background
Nasopharyngeal cancer (NPC) is a common cancer in Asia. In many developing countries, most cases are in advanced stages, compromising the outcome of treatment. The complexity of NPC management for advanced-stage NPC requires thorough communication and shared clinical decisions between medical professionals and allied teams. Incorporating a multidisciplinary team meeting (MDTM) for newly diagnosed NPC patients was chosen to facilitate clinical collaboration and communication between physicians. This recent study aimed to compare quality of care, clinical responses and survival between NPC patients treated inside and outside of MDTM care.
Methods
This was a retrospective study comparing NPC patients treated under the MDTM with NPC patients managed outsidethe MDTM. Clinical responses, assessment visits, date of progression and date of death were collected. Data were analyzed with X2 for discrete variables and t tests for continuous variables. Kaplan‒Meier survival curves with log-rank tests were used to describe the difference in survival estimation between the groups. Cox regression hazard models were calculated to predict the hazard risk for progression and survival. Significance was determined as p < 0.05.
Results
There were 87 patients treated under MDTM and 178 patients treated outside MDTM. Histology type of WHO type 3 was predominant. Stages IVA and B accounted for more than 60% of patients. Revision of diagnosis during MDTM accounted for 5.7%, and revision of stage occurred in 52.9%of cases. More clinical responses were achieved by patients treated under MDTM than by patients outside MDTM (69.0% vs. 32.0%, p < 0.00). The median progression-free survival of NPC patients under MDTM was 59.89 months compared with 12.68 months outside MDTM (log rank p < 0.00). Overall survival was longer in patients treated under MDTM compared with patients outside MDT (not reached vs. 13.44 months; p < 0.00). NPC patients who received treatment recommendations from the MDTM had a lower risk for progression (HR 0.267, 95% CI 0.17-0.40, p < 0.00) and mortality (HR 0.134; 95% CI 0.08 -0.24, p < 0.00).
Conclusion
Incorporating the MDTM approach into NPC management improves the clinical response and survival of patients.
A colorimetric detection of Hg2+ based on gold nanoparticles synthesized oxidized N-methylpyrrolidone as a reducing agent
Authors: Yang Dou , Guan Rentian , Jiang Shuhan , Wang Min , Zhang Shuai , Fan Xiaoyu , Shao Xiaodong , Liu Tao , Wang Shuhao , Yue Qiaoli 
Published: January 2023

Abstract
In this study, a gold nanoparticles colorimetric probe (AuNPs) with direct response to mercury ions (Hg2+) were developed using treated N-methylpyrrolidone (NMP) and chloroauric acid (HAuCl4) as precursors. NMP showed good reducibility after high temperature hydrolysis and could be used as reducing and stabilizing agent to synthesize AuNPs. The prepared AuNPs have obvious characteristic absorption peaks and appear wine-red. At the same time, it was found that the presence of Hg2+ can cause the aggregation of AuNPs, increased the absorbance at 700 nm, and changed the color of the solution into blue-gray. This method is capable of sensitive and specific determination of Hg2+ ranging from 1 to 30 µM, with the limit of detection (LOD) at 0.3 µM. The method showed good specificity for the determination of Hg2+ and has the potential to be applied to Hg2+ detection in sewage samples in the environment.
Association between cardiopulmonary bypass time and clinical outcomes among patients with acute respiratory distress syndrome after cardiac surgery
Authors: Hu Jiaxin , liu Yan , Huang Lixue , Song Man , Zhu Guangfa 
Published: January 2023

Abstract
Background:Cardiopulmonary bypass (CPB) can lead to lung injury and even acute respiratory distress syndrome (ARDS) through triggering systemic inflammatory response. The objective of this study was to investigate the impact of CPB time on clinical outcomes in patients with ARDS after cardiac surgery.
Methods:Totally, patients with ARDS after cardiac surgery in Beijing Anzhen Hospital from January 2005 to December 2015 were retrospectively included and were further divided into three categories according to CPB time during operation. The primary endpoints were the ICU mortality and in-hospital mortality, and ICU and hospital stay. Restricted cubic spline (RCS), logistic regression, cox regression model, and receiver operating characteristic (ROC) curve were adopted to explore the relationship between CPB time and clinical endpoints.
Results: Of the 54217 patients who underwent cardiac surgery during the above period, 210 patients developed ARDS after surgery and were finally included. The ICU mortality and in-hospital mortality were 21.0% and 41.9% in all ARDS patients after cardiac surgery respectively. Patients in category3 (CPB time ≥ 173 minutes) had longer ICU stay (P=0.011), higher ICU (P<0.001) mortality and in-hospital(P=0.002) mortality compared with those in category1 (CPB=0). For each ten minutes increment in CPB time, the hazards of a worse outcome increased by 13.3% for ICU mortality and 9.3% for in-hospital mortality after adjusting for potential factors.ROC curves showed CPB time presented more satisfactory power to predict mortality compared with APCHEII score. The optimal cut-off value of CPB time were 160.5 minutes for ICU mortality and in-hospital mortality.
Conclusion: Our findings firstly revealed the quantitative relationship between CPB time and clinical outcomes in patients with ARDS after cardiac surgery. Longer time of CPB was associated with poorer clinical outcomes, and could be served as an indicator to predict short-term mortality in patients with ARDS after cardiac surgery.
Longitudinal relationships between non-motor symptoms and biomarkers as a function of motor symptom asymmetry in early Parkinson’s disease
Authors: Voruz Philippe , Constantin Ioana , Peron Julie 
Published: January 2023

Abstract

Motor symptom asymmetry, a key feature of Parkinson’s disease, has been associated with differences in non-motor symptoms, such as cognitive and neuropsychiatric impairments, and in biomarker profiles. However, the longitudinal relationship between biomarkers and non-motor symptoms as a function of motor symptom asymmetry remains to be fully explored in early-stage patients. Clinical data from the Parkinson’s Progression Marker Initiative was extracted from 179 patients showing predominantly left-sided motor symptoms and 234 patients showing predominantly right-sided motor symptoms during a 3-year follow-up. General estimating equations revealed differential relationships over time between biospecimen and cognitive-neuropsychiatric scores based on motor symptom asymmetry. A more important implication of uric acid and beta-amyloid was noted in patients with predominantly left-sided motor symptoms, whereas patients with predominantly right-sided motor symptoms showed associations with alpha-synuclein and phosphorylated-tau levels. In summary, asymmetry of motor symptoms influences clinical trajectories in early-stage patients, holding important implications for symptom management in this clinical population.
Intramolecular Interactions (O-H•••O, C-H•••N, N-H•••π) in Isomers of Neutral, Cation, and Anion Dopamine Molecules - A DFT Study on the Influence of Solvents (Water and Ethanol)
Authors: Sangeetha Thekkayil , Lakshmipathi Senthilkumar 
Published: January 2023

Abstract
The investigation reports the intramolecular interactions present in the isomers of neutral (DA0), anionic (DA-), and cationic (DA+) dopamine isomers in gas, water, and ethanol mediums. Isomers of Cation dopamine show no intramolecular interactions in the solvent. Neutral and anion isomers have O-H∙∙∙O, C-H∙∙∙N hydrogen bonds and N-H⸳⸳⸳π interactions. All the interactions are electrostatic in nature. In solvents, intramolecular interactions are elongated and thereby weakened. Natural charges from NBO analysis show that O-H∙∙∙O bonds and the N- H∙∙∙π interactions are the most and least polar, respectively, among all the three interactions. 1H NMR study reveals the inverse linear correlation between shielding constant and electron density in a solvent medium. Homo-Lumo energy gap indicates higher stability for neutral and cationic forms of dopamine isomers in water and ethanol medium.
Exploring the impact of temperature and oxygen partial pressure on the spent nuclear fuel oxidation during its dry management
Authors: Milena-Perez Abel , Bonales Laura ,   Nieves Rodríguez-Villagra1, Galan Hitos 
Published: January 2023

Abstract

The management of Spent Nuclear Fuel (SNF) comprises different stages in which security is demonstrated. Nevertheless, fundamental research can lead to other design options that must be considered. Currently, one of the focuses is the dry interim storage option, as the shortest-term solution until final repositories are available. During this stage, one concern is the oxidation of the fuel. If UO2 (SNF matrix) is exposed to air at high-enough temperature, formation of U3O8 takes place. The larger volume of this phase could entail stresses on the SNF clad, which is the first barrier to prevent radioactive material release. It is known that this oxidation is a temperature-dependent reaction and ensuring an inert atmosphere discards any effect during SNF dry management. However, at what extent temperature and oxygen concentration would have an impact on the U3O8 formation is not established, being the available experimental data very scarce. We follow this oxidation in representative ranges of temperature and oxygen concentration of dry storage facilities by using in-situ Raman spectroscopy. The results show that temperature is a more-affecting factor than the oxygen concentration at the studied conditions. Therefore, efforts to limit temperatures would yield more benefits in preserving fuel matrix integrity.
Equilibrium behavior in tandem Markovian queues with heterogeneous delay-sensitive customers
Authors: Yiannis Dimitrakopoulos 
Published: January 2023

Abstract
We consider a system of two unobservable Markovian queues in tandem with strategic customers, who are heterogeneous regarding their delay sensitivity. The customers decide upon arrival whether to balk or join the system and receive service in the first queue, or in both queues. We analyze their equilibrium strategic behavior which is specified by double threshold strategies regarding their delay sensitivity parameter (one threshold for each queue). Moreover, we compare the strategic behavior of the heterogeneous customer population with its homogeneous counterpart. We complement our theoretical results with numerical experiments and provide managerial insight into the optimal control of the system parameters.
Vegetation Change in Katsina State, Nigeria: Influence of Local Perceptions and Land Use Land Cover Dynamics
Authors: Ahmad Mohammad Hadi , Jibrin Abdullahi , Ahmed Abubakar , Ishak Mohd Yusoff , Alatalo Juha M. , Danhassan Samir Shehu , Jiahua Zhang 
Published: January 2023

Abstract
Changing vegetation affects microclimates, groundwater tables, desertification, and biodiversity at the landscape level. The objective of this study is to assess the land cover dynamics and local perception of the influence of land use on vegetation change in Katsina State, Nigeria. Remote sensing and Geographic Information System (GIS)-based analysis, key informant interviews, and a semi-structured questionnaire covering 400 households were used to examine the driving forces behind vegetation change across Katsina State. As a result of the household survey, 86.5% (n = 400) of respondents reported a decline in vegetation in the study area, aligning with the Land Use Land Cover analysis phase of the study. The key drivers behind the observed vegetation depletion in the study area include firewood collection, charcoal production, and population growth. There has been an increasing awareness that education has emerged as one of the most significant socioeconomic factors influencing respondents' perceptions of these drivers. In spite of this, the unsustainable vegetation changes observed in this study have a negative impact on rural livelihoods and the management of natural resources in rural areas. This study recommends the implementation of sustainable land use policies that promote land-use practises that support economic growth and development.
Molecular typing and antimicrobial sensitivity of MDR-Pseudomonas aeruginosa isolated from Coronavirus disease-2019 patients
Authors: Shiralizadeh Somaye , Keramat Fariba , Hashemi Seyyed Hamid , Majzoobi Mohammad Mehdi , Azimzadeh Masoud , Alikhani Mohammad Sina , Karami Pezhman , Rahimi Zahra , Alikhani Mohammad Yousef 
Published: January 2023

Abstract
Background
Pseudomonas aeruginosa is a common co-infecting pathogen recognized among COVID-19 patients, leading to worsening illness and a high mortality rate. We aimed to demonstrate molecular typing and antimicrobial sensitivity of MDR-Pseudomonas aeruginosa isolated from COVID-19 patients.
Methods
Between December 2020 and July 2021, 15 P. aeruginosa were isolated from COVID-19 patients in the ICU ward at Sina Hospital in Hamadan, west of Iran. The Antimicrobial resistance of the isolates were determined operating the disk diffusion (DDT) and minimum inhibitory concentration (MIC) tests. The double-disk synergy method, Modified Hodge test, and PCR were utilized to detect P. aeruginosa extended spectrum beta-lactamase (ESBLs) and carbapenemase producers. Microtitre plate assay was operated to evaluate the biofilm formation ability of the isolates. The isolates' phylogenetic relatedness was revealed using the multilocus variable-number tandem-repeat analysis (MLVA) method.
Results
The results showed P. aeruginosa isolates had the most elevated resistance to imipenem (93.33%), levofloxacin (93.33%), trimethoprim-sulfamethoxazole (93.33%), ceftriaxone (80%), ceftazidime (80%), gentamicin (60%), ciprofloxacin (60%), and cefepime (60%). In the broth microdilution method, 100%, 100%, 13.33%, and 20% of isolates showed resistance to imipenem, meropenem, colistin, and polymyxin B, respectively. Extended-spectrum beta-lactamases and carbapenemase enzymes were detected in 20% and 66.66% of the isolates, respectively. Biofilm formation was seen in 100% of isolates. On the basis of the PCR results, blaOXA−48, blaTEM, blaIMP, blaSPM, blaPER, blaVEB, blaNDM, blaSHV, and blaCTX−M were detected in 100%, 86.67%, 86.67%, 40%, 20%, 20%, 13.33%, 6.67%, and 6.67%, of the isolates, respectively. The MLVA typing technique showed 11 types and seven main clusters. Most isolates belonged to clusters VII, I, and V.
Conclusions
As to observe high genetic diversity among P. aeruginosa isolates from COVID-19 patients in the ICU, it is indispensable to regularly monitor the epidemiology and genetical relatedness of the isolates to trace any insignificant alteration in the epidemiology of P. aeruginosa isolates in the COVID-19 epidemic.
The "ViaHole" technique for recanalization of a major side branch occluded by a Viabahn stent-graft
Authors: Haraguchi Takuya , Tsujimoto Masanaga , Otake Ryo , Kashima Yoshifumi , Sato Katsuhiko , Fujita Tsutomu 
Published: January 2023

Abstract
Background: Heparin-bonded endoluminal stent grafts covered with expanded polytetrafluoroethylene (ePTFE) are used for iatrogenic arterial injuries. Where the stent-graft is implanted across a major side branch for hemostasis, the branch can become occluded. We propose the ViaHole technique as a novel recanalization method for major side branches covered by a stent-graft.
Case presentation: A 72-year-old male with a right popliteal aneurysm was treated using an 8.0 mm × 250 mm stent-graft from the distal superficial femoral artery (SFA) to the popliteal artery. He later presented with acute limb ischemia (ALI), and during treatment, perforation occurred and was repaired using 5.0 × 50 mm and 100 mm stentgrafts from the tibio-peroneal trunk across the peroneal artery (PA) to the posterior tibial artery (PTA). Unfortunately, ALI reoccurred 3-months later, and the initial angiography showed thrombotic occlusion from the distal SFA to the below-the-knee arteries. After successful thrombo-aspiration of the above-the-knee arteries, revascularization of the tibial arteries failed because of a massive thrombus.
We attempted to recanalize the PA, whose orifice had been covered by stent-graft placement. First, we advanced a 0.014-inch guidewire with a microcatheter from the distal PTA through the communicating branch to the ostium of the PA. Second, a 20-gauge needle was used to puncture the proximal lower thigh, through the stent-graft to the tip of the retrograde guidewire in the PA orifice. Third, after the needle touched the guidewire tip, the guidewire was advanced out of the body through the hole of the needle to externalize the guidewire. Fourth, the retrograde microcatheter was forcibly advanced over the externalized guidewire across the ePTFE into PTA. Fifth, the antegrade guidewire was passed through the retrograde microcatheter, and the antegrade microcatheter was advanced into the PA through the hole of the stent-graft. After the antegrade guidewire crossed the lesion, a 3.0 mm semi-compliant balloon dilated the lesion and the stent-graft hole. Finally, the angiogram showed sufficient blood flow. A 6-month computed tomography angiogram showed no restenosis of the treated lesion.
Conclusions: The ViaHole technique is an effective recanalization procedure for major branches occluded by Viabahn implantation for iatrogenic complications.
Prophylactic antibiotic for preventing ventilator-associated pneumonia: a pairwise and Bayesian network meta-analysis
Authors: He Zhengfeng , Niu Jianyi , Zha Shanshan , Fu Wei , Huang Qiaoyun , Guan Lili , Zhou Luqian , Chen Rongchang 
Published: January 2023

Abstract
Background
The role of prophylactic antibiotics in preventing ventilator-associated pneumonia (VAP) for patients undergoing invasive mechanical ventilation (IMV) remains unclear. This network meta-analysis aimed to compare the efficacy and safety of antibiotic prophylaxis in preventing VAP for IMV population in intensive care unit (ICU).
Methods
We searched the PubMed, Web of Science, Embase and Cochrane Library databases from inception to December 2021, to identify relevant studies assessing the impact of prophylactic antibiotics on the incidence of VAP, mortality, the duration of ICU stays and hospitalization to perform a meta-analysis.
Results
Thirteen studies (2144 patients) were included, twelve of which selected for primary analysis revealed that prophylactic antibiotics resulted in a lower VAP rate compared with control groups (risk ratio [RR] = 0.62). Bayesian network meta-analysis found that aerosolized tobramycin and intravenous ampicillin-sulbactam presented the greatest likelihood to be most efficient regimen for reducing VAP.
Conclusions
Antibiotic prophylaxis may reduce the incidence of VAP, but not mortality, for adult patients undergoing IMV in ICUs. Tobramycin via nebulization and ampicillin-sulbactam via intravenous administration presented the greatest likelihood to be most efficient regimen for preventing VAP. However, well-designed randomized studies are warranted to make definite recommendations.
Distribution of uterocervical angles of pregnant women at 16+0 to 23+6 weeks gestation with low risk for preterm delivery: First Vietnamese cohort of women with singleton pregnancies
Authors: Hoang Trang Nguyen Thi , Van Tam Vu , Quoc Huy Nguyen Vu 
Published: January 2023

Abstract
Background: Cervical length (CL) measured by ultrasound in the second trimester is a predictor of spontaneous preterm birth (sPTB). The uterocervical angle (UCA) has recently been investigated as a parameter to identify women at risk of sPTB. This study aimed to investigate the UCAs’ distribution in singleton pregnant women at 16+0-23+6 weeks of gestation with low risk for sPTB.
Methods: This was a prospective cohort study of 1,051 pregnant women with singleton pregnancies at low risk for preterm delivery. Pregnant women with a viable singleton fetus at 16+0-23+6 weeks of gestation were enrolled in the study conducted at the Haiphong Hospital of Obstetrics and Gynecology, Vietnam, from 09/2019 to 09/2020.
CL and the UCA were assessed using transvaginal ultrasonography (TVS) by a single sonographer. Subjects were followed-up until the end of pregnancy, and maternal and neonatal outcomes were recorded. The UCAs’ range and their relationship with gestational age were evaluated using regression analysis. P<0.05 was considered statistically significant.
Results: The normal range of the UCA (5th-95th percentiles) was 46.47° (95% CI, 40.27°-51.81°) to 127.06° (95% CI, 123.02°-130.71°). The UCAs in the preterm birth (<37 weeks) and full-term groups were 117.86°±20.25° and 83.80°±24.18°, respectively (p<0.001). Linear regression analysis showed a significant change in the UCA range from 16+0 to 23+6 weeks of gestation (2.51 degrees per week, p<0.001). The quadratic function yielded the highest correlation coefficient in the variation rule of the UCA values (r2=0.051). A total of 42/63 (66.7%) patients with preterm birth <37 weeks had a UCA above the 75th percentile. The rate of UCA values ≥95° was significantly higher in the sPTB group than in full-term delivery group (88.9% vs. 31.3%, p<0.001).
Conclusions: The UCA values in the preterm birth <37 weeks group were significantly wider in the full-term delivery group (p<0.001), and the majority of women with preterm birth had an UCA ≥ 95° compared with those with full-term delivery (p<0.001). It is advisable to monitor the UCA, especially in pregnant women with a UCA value ≥ 95° at 16+0-23+6 weeks of gestation.
Changes in condylar position during orthodontic treatment depending on the amount of incisor retraction: a cone-beam computed tomography study
Authors: Cho Sang Ah , Chang Pi-En , Koh Bumyeon , Park Younjung , Park Jung Jin , Choi Yoon Jeong 
Published: January 2023

Abstract
Objectives
Orthodontic treatment may be related to temporomandibular disorders through changes in condylar position. This study aimed to evaluate changes in the condylar position during orthodontic treatment and compare those changes depending on the amount of incisal retraction using cone-beam computed tomography (CBCT) images.
Materials and Methods
Fifty-four participants were enrolled and divided into minimal (n = 14), moderate (n = 20), and maximal (n = 20) retraction groups according to the amount of incisor retraction (< 1, 1–6, and > 6 mm, respectively). Changes in the condylar position before (T0) and after (T1) orthodontic treatment were assessed for the superior, anterior, posterior, and medial joint spaces (SJS, AJS, PJS, and MJS, respectively). Changes in joint spaces were compared between T0 and T1 in each group using paired t-tests and among the three groups using analysis of variance.
Results
Anterior movement of the condyle was observed in the maximal retraction group with 0.2 mm decrease in ΔAJS and 0.2 mm increase in ΔPJS, which were significantly greater than those in the minimal retraction group. AJS and PJS showed statistically significant differences between T0 and T1 (P < 0.05) in the maximal retraction group.
Conclusions
The condyle may show a statistically significant but clinically insignificant forward movement in the maximal retraction group. However, it remained in an optimal position in the fossa throughout the orthodontic treatment.
Clinical Relevance
More attention should be paid while examining the signs and symptoms related to the condyle in patients with excessive incisal retraction during orthodontic treatment.