bluuebunny/crossref_metadata_2025_split huggingface dataset:
Single-stent strategy for left coronary artery bifurcation lesions in patients with chronic ischemic heart disease: protocol of a randomized trial
Authors: Khokhlunov S. M. , Salamov G. V. , Kislikhin Т. V. , Kostyrin E. Yu. , Tumanov A. I. , Titov A. L. , Patrikeeva A. A. 
Published: July 2023

Aim. This study aims to compare the intraoperative, immediate postoperative and long-term postoperative results of stenting followed by final kissing balloon angioplasty (FKB) and without FKB for left coronary artery (LCA) bifurcation lesions in patients with chronic ischemic heart disease.Material and methods. We plan to perform an open-label, prospective, randomized, single-center, cohort trial that will include 40 patients with left main coronary artery bifurcation lesion, who will undergo stenting procedure followed by FKB or without FKB, using the second-generation drug-eluting stents. Randomization into two groups will be done after performing coronary angiography, confirming the inclusion criteria and the absence of non-inclusion criteria and signing a written consent in 2 copies. Group 1 — stenting followed by FKB. Group 2 — stenting without FKB. The total follow-up period is 24 weeks. It is planned to contact by phone on 30th and 180th day (±7 days) of postoperative period to obtain the information about patient condition, general survival rate, the events of combined controlled points and drug therapy. During 2d phone contact, on 180th day (±7 days), a patient will be invited to undergo multispiral computed tomography of the coronary arteries.The primary combined end-point: cardiac death, nonfatal myocardial infarction, acute cerebrovascular accident and the repeat target vessel revascularization. The secondary combined end-point: thrombosis and stent restenosis.Conclusion. Our study will optimize the approach to the choice of stenting strategy (with or without FRB) for left main coronary artery bifurcation lesions in patients with chronic ischemic heart disease.
Association of cystatin C with changes of left ventricular structure and function in individuals with different cardiovascular risk
Authors: Murkamilov I. Т. , Fomin V. V. , Sabirov I. S. , Yusupov F. A. 
Published: July 2023

Aim. This study aims to investigate the association of cystatin C with changes of left ventricular structure and function in individuals with different cardiovascular risk (CVR).Material and methods. 267 patients with low-moderate (group I, n=58), high (group II, n=80) and extremely high (group III, n=129) CVR were examined. The level of serum cystatin C, creatinine and blood lipid spectrum, filtration rate of the kidneys and echocardiography indicators were estimated.Results. Among all the study participants (n=267), 194 patients (72,6% of cases) had the increased level of serum cystatin C; 165 patients (61,7% of cases) showed the signs of the left ventricular hypertrophy (LVH). The increased level of serum cystatin C was observed in 51,7% of cases in group I; 75,0% — in group II and 80,6% — in group III. The values of glomerular filtration rate (GFR) calculated using the CKD-EPI and F. Hoek formula were the following: 100,2±17,0 ml/min/1,73 m2 and 84,8±15,5 ml/min/1,73 m2, p<0,05 in group I; 81,2±21,6 ml/min/1,73 m2 and 63,1±18,3 ml/min/1,73 m2, p<0,05 in group II; 63,0 (32,0;93,0) ml/min/1,73 m2 and 55,1 (22,1;70,7) ml/min/1,73 m2 — in group III. The LVH detection increased with the increase of the CVR degree (43,1% — in group I; 66,2% — in group II and 67,4% in group III). Relative wall thickness (RWT, units) increased significantly from the patients of group I (0,34±0,04 units) to the patients of group II (0,37±0,08 units) and III (0,38±0,06 units). Eccentric variant of LVH significantly prevailed in all the groups. On one side, it was found that the level of serum cystatin C was in direct correlation with left ventricular mass index (LVMI, r=0,268, p<0,05) and left ventricular RWT (r=0,190, p<0,05), and on the other side, the inverse relationship between LVMI and GFR for cystostatin C was observed (r=-0,324, p<0,05).Conclusion. The results of the study showed that the level of serum cystatin C and LVMI value significantly increase with the increase of the CVR degree. The high levels of serum cystatin C are closely associated with the increase of LVMI and the changes in the RWT value. In turn, the increase of LVMI negatively correlated with filtration rate of the kidneys in patients with different CVR. Concerning the structural changes in the left ventricle, eccentric HLV prevailed in all the three groups.
accesibilidad cognitiva en el punto de mira. Análisis de una experiencia de futuros docentes sobre la evaluación del entorno
Authors: Tárraga Minguez Raúl , Gómez-Marí Irene 
Published: July 2023

La accesibilidad cognitiva hace referencia a las características de los entornos para que sean más sencillos de comprender. En entornos escolares la accesibilidad cognitiva es especialmente importante para los niños y niñas con necesidades específicas de apoyo educativo, por lo que el profesorado debe tener la formación adecuada para hacer los entornos más accesibles. En el presente estudio se llevó a cabo una experiencia de formación inicial de profesorado sobre la accesibilidad cognitiva en el entorno universitario. Participaron 38 estudiantes del grado de Maestro/a en Educación Infantil que cumplimentaron un cuestionario con preguntas tipo Likert y de respuesta corta. Los resultados muestran que la accesibilidad cognitiva era un concepto desconocido para los estudiantes antes de la actividad formativa, pero que tras su realización aumentaron su conocimiento sobre el tema, mantuvieron un nivel de motivación elevado y manifestaron su intención de llevar a cabo en el futuro acciones para mejorar la accesibilidad cognitiva de centros educativos.
The relationship between neuropathic pain and serum endocan, ET-1, IL-1, IL-6, IL-8, MCP-1, TNF-α, VEGF-A levels in fibromyalgia patients and molecular docking results
Authors: BALBALOĞLU Özlem , İNANDIKLIOGLU Nihal , RAHEEM Kayode Yomi 
Published: July 2023

Purpose: The most important clinical finding of fibromyalgia syndrome (FMS) is pain. Its etiology has not been fully elucidated. This study was planned to determine the relationship between endocan, ET-1, IL-1, IL-6, IL-8, MCP-1, TNF-a, VEGF-A levels and pain/neuropathic pain in FMS patients.
Materials and Methods: Forty-four FMS patients who met the inclusion criteria and 44 age-matched premenopausal healthy controls were recruited. The fibromyalgia group was evaluated in terms of Visual Analog Scale, Beck Depression Scale, Beck Anxiety Scale, Fibromyalgia Impact Questionnaire and LANSS Pain Scale. Serum endocan, ET-1, IL-1, IL-6, IL-8, MCP-1, TNF-α, and VEGF-A values were determined by the ELISA method. Protein-protein interaction was evaluated by molecular docking analysis. Bioinformatics analysis was performed using the STRING v 11.5 protein interaction tool.
Results: Endocan, ET-1, IL-1, IL-6, IL-8, MCP-1, TNF-α, and VEGF-A were significantly higher in FMS patients than the control group. 24 of 44 patients had neuropathic pain. No correlation was found between pain/neuropathic pain and serum markers levels. High interaction and homology scores of the proteins were defined.
Conclusion: The pain/neuropathic pain relationship of these markers could not be determined, but the calculated binding energies and activities of the proteins provided important clues for future studies.
Trabajo informal en espacio público desde la perspectiva de los derechos humanos
Authors: Forero Umaña Diana Paola , Rodriguez Rodriguez Christian Camilo 
Published: July 2023

En la actualidad, el tema del trabajo informal reviste gran importancia en cuanto análisis y reflexión de una situación que se convierte en problemática cuando las personas que trabajan en el espacio público se ven enfrentados a retos relevantes para conseguir hacer legítimos sus derechos. En este marco se inserta la temática que se analizó en este caso con el propósito de, delimitar las condiciones a través de las cuales los vendedores estacionarios y ambulantes del centro histórico de Chiquinquirá, son visibilizados como fenómeno social que debe ser atendido a partir de su reconocimiento como personas con derecho al trabajo, al uso y disfrute del espacio público. La reflexión se centró en el contexto particular de la localidad de Chiquinquirá en el departamento de Boyacá, Colombia y se ubicó en el marco de los derechos humanos. Metodológicamente, corresponde a una investigación cualitativa con enfoque de estudio de caso y el uso de la entrevista como medio para la obtención de información proporcionada por los participantes; el análisis de la misma se hizo mediante un proceso lógico y coherente que llevó a establecer lo significativo de la realidad investigada. El principal hallazgo expresa que las y los vendedores informales no son tratados y reconocidos como sujetos con derecho al trabajo en un contexto que no les proporciona condiciones para vivir, desarrollar sus capacidades y proyectos de vida tanto de forma individual como del grupo familiar.
Investigating the Relationship between Internet Addiction and Dietary Behavior among Students: an analytical cross-sectional study
Authors: Dehghani Ali , Darvish Asieh , Barikani Atefeh 
Published: July 2023

Background: Internet addiction can affect students' general health. Regarding to the importance of healthy eating and the impact on health and academic achievement of students. This research was conducted to aim the assessment of relationship between internet addiction and dietary behavior among students.
Methods: In this an analytical cross-sectional study, 373 nursing and midwifery students of Tehran University of Medical Sciences participated in 2020. Data were collected by Young's Internet Addiction Scale, demographic data and Dietary Behavior questionnaire. Data analyzed by SPSS V.21 and descriptive indicators including percentage, frequency, mean and standard deviation and inferential tests including Spearman’s test, T-test and Kruskal-Wallis. A significance level of less than 0.05 was considered
Results: The majority of the student population had no internet addiction by 91.4%. Also, 8.3% and 0.3% from student population were potential risk and high risk respectively. There was a statistical significant correlation between levels of internet addiction and dietary behavior in high-fat diets (r = 0.483, P = 0.004), snacking (r = 0.455, P < 0.001), emotional eating behavior (r = 0.543, P < 0.001) and poor dietary pattern (r = 0.632; P < 0.001).
Conclusions: It is suggested to improve students' beneficial use of the internet with training and improve their dietary behavior.
Comparison of the postoperative analgesic efficacy of ultrasound-guided suprainguinal fascia iliaca block applied with two different concentrations of bupivacaine in patients undergoing hip surgery under spinal anesthesia
Authors: Koc Kadem , Kucuk Ordulu Busra Burcu , Ferli Ramazan Burak , Yesilyurt Busra , Guzel Nizamettin , Tulgar Serkan , Suren Mustafa 
Published: July 2023

Aim: Management of postoperative pain in hip surgeries is important for the quality of recovery. When regional anesthesia techniques are added to the multimodal analgesia plan, they increase the effectiveness of the analgesia plan. Supra-inguinal fascia iliaca block (SIFIB) is a technique that has been reported to be effective in hip surgery but requires the use of high-volume local anesthetics. Our aim in this retrospective study is to investigate the efficacy of local anesthetic in SIFIB when administered at a concentration lower than the conventional concentration.Material and Methods: The files of the patients who underwent hip hemiarthroplasty were planned to be evaluated retrospectively. Patients were grouped according to the bupivacaine concentration used in SIFIB (0.25% vs. 0.20%) and statistically evaluated in terms of morphine requirement, pain scores, and time to first analgesic.Results: There was no significant difference between the groups in terms of NRS score and cumulative morphine consumption at the 3rd, 6th, 12th, 18th, and 24th hours (p>0.05). When compared the first analgesia requirement times, there was no significant difference between Groups (p>0.05).Conclusion: A single shot SIFIB administered at a concentration of 0.20% also has analgesic properties, as do the conventional concentration of SIFIB containing 0.25% bupivacaine.
Control of the critical points for the safety of pasteurized milk in CV Cita Nasional
Authors: Aji Hutama Puranto , Nuhriawangsa Adi Magna Patriadi , Kartikasari Lilik Retna 
Published: July 2023

<p>This study aims to determine the control of critical points in the production of pasteurized milk in CV. Cita Nasional by implementing the Hazard Analysis Critical Control Point (HACCP) system. This research was descriptive qualitative with the aim of exploring the data in depth and specifically. The data collection techniques used were interviews and observation. Interviews were conducted in each part of pasteurized milk Furtherstep was observation techniques to collect data to determine the critical point of pasteurized milk production in all production chains. Control of the critical point of pasteurized milk production in CV. Cita Nasional by determining the source of contamination in each part of production. The source of danger in the mixing process is contamination from tools, workers and the environment. The source of danger in the pasteurization and homogenization process is the pasteurization time and temperature that are not fulfilled. The source of danger in the cooling process is contamination by spore-forming bacteria that do not die during the pasteurization process. Sources of danger during the packaging process come from packaging that is less sterile, contamination from workers and the environment. The source of danger from the distribution process to consumers is product temperature fluctuations and container damage during the shipping process. Control of the critical points for pasteurized milk is carried out by applying SOP and HACCP principles as an effort to prevent and guarantee products that can be consumed in a Safe, Healthy, Whole and Halal (ASUH) way.</p>
Kerjasama Kemitraan Lebah Klanceng Antara Masyarakat Bali dengan PT. Maha Agung Indonesia Bersama (PT. MIB) Perspektif Hukum Islam
Authors: Antari Andrie Nindy Dwi , Sari Ima Frafika , Razdana Verendhea 
Published: July 2023

The contract used in the bee clanceng partnership is the shirkah contract. The distribution of cultivation profits for the community is Rp. 500,000 per package for 4 months, while PT. MIB benefits from the volume of honey produced by the clanceng bee cultivation that has been cultivated by partners, with no clarity on the volume of the cultivated honey. The aims of this study are: 1) To find out the review of Islamic law on the bee clanceng partnership agreement between the community and PT. MIB, 2) To find out the review of Islamic law on profit sharing in the bee clanceng partnership between the community and PT. MIB, The researcher uses the inductive method, which describes specific empirical facts and then draws generalizations (theoretical explanations). The result of this research is a partnership agreement between the community and PT. MIB uses a shirkah contract, namely shirkah 'inan. The shirkah contract is valid and in accordance with Islamic law because it has fulfilled the pillars and conditions of shirkah. Then the profit sharing in the bee clanceng partnership between the community and PT. MIB is legal and in accordance with Islamic law, because the distribution of profits is proportional according to the capital issued and based on an agreement.
Akad yang digunakan dalam kerjasama kemitraan lebah klanceng adalah akad shirkah. Pembagian keuntungan budidaya bagi masyarakat Bali sebagai mitra sebesar Rp 500.000 per paket selama 4 bulan, sedangkan PT. MIB mendapatkan keuntungan volume madu hasil budidaya lebah klanceng yang telah dibudidaya oleh mitra, dengan tidak ada kejelasan besarnya volume madu hasil budidaya tersebut. Tujuan dari penelitian ini adalah: 1) Untuk mengetahui tinjauan hukum Islam terhadap akad kerjasama kemitraan lebah klanceng antara masyarakat Bali sebagai mitra dengan PT. MIB, 2) Untuk mengetahui tinjauan hukum Islam terhadap pembagian keuntungan dalam kerjasama kemitraan lebah klanceng antara masyarakat Bali sebagai mitra dengan PT. MIB, Peneliti menggunakan metode induktif yaitu memaparkan fakta-fakta empirik yang bersifat khusus kemudian ditarik generalisasi yang bersifat umum (penjelasan teoritis). Hasil penelitian ini adalah akad kerjasama kemitraan lebah klanceng antara masyarakat Bali sebagai mitra dengan PT. MIB menggunakan akad shirkah, yaitu shirkah ‘inan. Akad shirkah tersebut sah dan sesuai dengan hukum Islam karena telah memenuhi rukun dan syarat shirkah. Kemudian pembagian keuntungan dalam kerjasama kemitraan lebah klanceng antara masyarakat Bali sebagai mitra dengan PT. MIB adalah sah dan sesuai hukum Islam, karena pembagian keuntungan proporsional sesuai dengan modal yang dikeluarkan dan berdasarkan kesepakatan.
Kredit Barang Rumah Tangga Prespektif Etika Bisnis Islam
Authors: Fitria Maulidda , Mukhlas Moh. , Lestari Rike Navasa Wiji , Nurhaliza Rizka Putri 
Published: July 2023

In the case of credit for household goods in Mawatsari Hamlet, several items can be taken as credit items, including carpets, mattresses, pillows, pans, and several other household items, and in this place, only use payment transactions with two options, namely by repay in installments every month or pay off directly at the end of a predetermined time, usually the payment time is 3 to 4 months after receiving the goods because you can't pay directly sometimes it makes many people who originally had money to pay but then when the time for payment comes to the money to pay is already used for other things. This study aims to: explain the implementation of household goods credit in Mawatsari Hamlet, Datangan District, Madiun Regency, and to describe the Perspective of Islamic Business Ethics on Credit for Household Goods in Mawatsari Hamlet, Datangan District, Madiun Regency. In this study, the authors conducted field research (field research). Researchers used a qualitative approach, namely collecting data from existing facts. For data processing, the authors used editing and finding results. On this basis, credit was used. This study concluded that: the credit agreement for household goods in Mawatsari Hamlet is not by Islamic business ethics because there is still non-fulfillment of agreements made before the transaction is carried out. Some factors trigger lousy credit.
Dalam kasus kredit barang rumah tangga di Dusun Mawatsari terdapat beberapa barang yang dapat diambil sebagai barang kredit di antaranya yaitu: karpet, kasur, bantal, panci, dan beberapa barang rumah tangga lainnya, dan di tempat ini hanya menggunakan transaksi pemembayaran dengan dua pilihan yaitu dengan mencicil setiap bulan atau melunasi langsung di akhir waktu yang telah ditentukan, biasanya p waktu pembayaran 3 sampai 4 bulan setelah penerimaan barang, karena tidak dapat membayar langsung terkadang menjadikan banyak orang yang semula mempunyai uang untuk membayar namun dikemudian saat waktu pembayaran tiba uang untuk membayar sudah digunakan untuk hal lainnya.Penelitian ini bertujuan untuk : menjelaskan pelaksanaan kredit barang rumah tangga di Dusun Mawatsari Kecamatan Dagangan Kabupaten Madiun dan untuk mendeskripsikan Prespektif Etika Bisnis Islam terhadap Kredit Barang Rumah Tangga Di Dusun Mawatsari Kecamatan Dagangan Kabupaten Madiun. Dalam penelitian ini, penulis melakukan penelitian lapangan (fileld ressearch. Peneliti dalam melakukan penggalian data menggunakan pendekatan kualitatif, yaitu mendata dari fakta yang ada. Untuk pengolahan data penulis menggunakan editing dan penemuan hasil. Pada landasaan ini yang digunakan yaitu kredit. Hasil penelitian ini menyimpulkan bahwa: akad kredit barang rumah tangga di Dusun Mawatsari belum sesuai dengan etika bisnis Islam, karena masih adanya ketidakterpenuhinya kesepakatan yang telah dibuat sebelum transaksi dilakukan, dan adanya faktor yang memicu terjadinya kredit mancet.
An Impulse-Quantizing Synchronization Approach for Mixed Continuous-Discrete Complex Networks
Authors: Hu Na , Li Luyan , Bin Honghua , Huang Zhenkun 
Published: July 2023

Abstract
This paper presents synchronization of mixed continuous-discrete complex network
via impulse-quantizing approach. A delay-partitioning group strategy is proposed
and impulse-quantizing control is designed to derive theoretical criteria ensuring
scale-type synchronization of complex networks. Our results show that synchronization
of mixed continuous-discrete complex networks can be realized by controlling
delay-partitioning subgroup nodes with impulsive quantization. The theoretical results
give scale-limited sufficient conditions for quantized synchronization relying on
control gains, impulsive intervals and delays. A numerical simulation is given to
demonstrate the effectiveness of the theoretical results.
A Novel AP2/ERF Transcription Factor, NtERF10, Positively Regulates Plant Height in Tobacco
Authors: Xu Li , Xu Yong , Jiang Jia-rui , Cheng Chang-xin , Yang Wen-wu , Deng Le-le , Mi Qi-li , Zeng Wan-li , Li Jing , Gao Qian , Xiang Hai-ying , Li Xue-mei 
Published: July 2023

Abstract

Ethylene response factors have been shown to be involved in the effects of plant developmental processes and to regulate stress tolerance. The aim of this study was to recognize the regulatory mechanisms of ethylene response factors on tobacco plant height. In this study, a gene-edited mutant (ERF10-KO) and wild type (WT) were utilized as experimental materials. Transcriptome and metabolome analyses were used to investigate the regulatory mechanism of NtERF10 gene editing on plant height in tobacco. Here, through the analysis of differentially expressed genes (DEGs), 2051 genes were upregulated and 1965 genes were downregulated. We characterized the different ERF10-KO and WT plant heights and identified key genes for photosynthesis, the plant hormone signal transduction pathway and the terpene biosynthesis pathway. NtERF10 was found to affect the growth and development of tobacco by regulating the expression levels of the PSAA, PSBA, GLY17 and GGP3 genes. Amino acid metabolism was analyzed by combining analyses of differentially expressed genes (DEGs) and differentially accumulated metabolites (DAMs). In addition, we found that members of the bHLH, NAC, MYB, and WRKY transcription factor (TF) families have vital roles in regulating plant height. This study not only provides important insights into the positive regulation of the ethylene response factor NtERF10 on plant height during plant growth and development but also provides new research ideas for tobacco molecular breeding.