bluuebunny/crossref_metadata_2025_split huggingface dataset:
Novel Cyclopropyl Compounds, Cyclopropylvirgines A to G, from the Fruiting Bodies of Amanita Virgineoides
Authors: Wu Jing , Kamiishi Yusaku , Shimozaki Kouhei , Kondo Mitsuru , Hashimoto Masaru , Choi Jae-Hoon , D’Alessandro-Gabazza Corina N , Toda Masaaki , Yasuma Taro , Gabazza Esteban C , Hirai Hirofumi , Kawagishi Hirokazu 
Published: May 2023

Abstract
Seven novel compounds (1–7) along with four known compounds (8–11) were isolated from the fruiting bodies of Amanita virgineoides. The structures of 1–7 were determined by the interpretation of spectroscopic data. Compounds 1–7 were racemates, and 5–7 were separated to each enantiomer (5a, 5b, 6a, 6b, 7a and 7b). The absolute configurations of compounds 5a and 5b were determined by single-crystal X-ray diffraction analyses, and those of 6a, 6b, 7a and 7b were determined by comparison of their CD spectra with those of l-cyclopropylalanine, 5a and 5b. Although compounds 5b, 8–11 had been synthesized, they were isolated from a natural source for the first time. Compounds 6b, 8 and 11 showed significant inhibition activity against Axl and/or immune checkpoint (PD-L1, PD-L2).
Παράγοντες που ανάγονται σε επίπεδο σχολικής μονάδας και καθορίζουν την ενεργό συμμετοχή των μαθητών
Authors: Τσιάρα Ευθυμία , Σακελλαριου Μαριγούλα , Καλογιαννάκη Πέλλα , Κόνσολας Εμμανουήλ 
Published: May 2023

Η σχολική μονάδα ως περιβάλλον και πεδίο μάθησης μπορεί να διαφοροποιήσει την αλληλεπίδραση των μαθητών τόσο μεταξύ τους όσο και με τον εκπαιδευτικό, αλλά και να καθορίσει την ενεργό συμμετοχή τους στη διαδικασία μάθησης. Η σχολική μονάδα διέπεται από ποικίλους παράγοντες που αναφέρονται στον σχολικό χώρο και τα προσδιοριστικά του χαρακτηριστικά, στο παιδαγωγικό κλίμα με τις διαπροσωπικές σχέσεις που σε αυτό αναπτύσσονται, καθώς και στο επίσημο αναλυτικό πρόγραμμα που εφαρμόζεται. Λαμβάνοντας υπόψη λοιπόν τους παραπάνω παράγοντες, όπως προσδιορίζονται στη διεθνή βιβλιογραφία, κρίνουμε απαραίτητο να διερευνήσουμε τις απόψεις εν ενεργεία Ελλήνων εκπαιδευτικών αναφορικά με την επίδραση που οι ενδοσχολικοί παράγοντες ασκούν στην ενεργό συμμετοχή των μαθητών προσχολικής και πρώτης σχολικής ηλικίας. Για τον παραπάνω σκοπό πραγματοποιήσαμε ημιδομημένες ατομικές συνεντεύξεις σε δείγμα 95 εκπαιδευτικών πρωτοβάθμιας εκπαίδευσης. Για τον σχεδιασμό των συνεντεύξεων υιοθετήσαμε το μοντέλο οργάνωσης και λήψης συνέντευξης της Creswell (2008), ενώ για τη διεξαγωγή τους χρησιμοποιήσαμε οδηγό συνέντευξης με 198 ερωτήσεις ανοιχτού και κλειστού τύπου. Πρόκειται για μια διετή έρευνα που πραγματοποιήθηκε σε δύο φάσεις κατά τα διδακτικά έτη 2017-18 και 2019-2020. Τα αποτελέσματα από την ποσοτική και ποιοτική (επαγωγική ανάλυση δεδομένων) ανάλυση των δεδομένων δείχνουν ότι οι εκπαιδευτικοί του δείγματος αναγνωρίζουν ότι η σχολική μονάδα ως σύνολο ενδοσχολικών παραγόντων που τη διέπουν καθορίζει σημαντικά τα επίπεδα ενεργού συμμετοχής που οι μαθητές επιδεικνύουν. Οι συνεντευξιαζόμενοι, αν και προσδίδουν υψηλή σημαντικότητα στο παιδαγωγικό κλίμα και στο ανθρώπινο δυναμικό που στελεχώνει τη σχολική μονάδα, και ακολούθως στις κτιριακές υποδομές και το διαθέσιμο εποπτικό υλικό, αναγνωρίζουν ότι ο συνδυασμός των διάφορων ενδοσχολικών παραγόντων διαμορφώνουν εν τέλει την ενεργό συμμετοχή των μαθητών.
Scopus based bibliometric and scientometric analysis of occupational therapy publications from 2001 to 2020
Authors: Sau Koushik , Nayak Yogendra 
Published: May 2023

Background: Occupational therapy (OT) is one of the allied health professions, with its first journals in 1920. The main objective of this study was to find out the publication trend in the field of OT research for the period of 2001-2020 using the principles of bibliometrics and scientometrics. Methods: The data was retrieved from Scopus from the past 20 years (2001-2020). VOSviewer software was used to find year-wise publications in OT-specific and non-OT-specific Journals along with top journals, countries, organisations, authors, cited articles, and highly used keywords. Results: There was a steady growth of OT articles over the past 20 years. Scopus indexes 16 OT-specific journals are identified. American Journal of Occupational Therapy, British Journal of Occupational Therapy Journal, Australian Occupational Therapy Journal, Scandinavian Journal of Occupational Therapy, and Canadian Journal of Occupational Therapy are the leading publications and citations. A comparison of OT-specific and non-OT journals inferred that the OT-specific papers are three times more published in non-OT journals. There is a trend in publishing multidisciplinary medical journals than OT journals. The US publishes the most articles, followed by the UK, Australia, Canada, and Germany. Though the US alone produced a considerable number of articles (9517), only five organisations are listed in the top 20, compared to Canada (n=6) and Australia (n=5). Australia represents the highest number of published authors (n=11/20). Canada represents a highly cited author from the top-cited publications. The five common keywords used by OT-authors are "occupational therapy", “rehabilitation”, “stroke”, “physical therapy,” and “activities of daily living”. This study lists top-20 journals along with their CiteScore and Journal Impact Factor. Conclusions: This study will help the budding researchers in OT to select a suitable quality journal for publication and, further, helpful for research promotion, researcher incentivising, grant allocations, and policymakers in the OT field.
ЗАМЕТКИ О ПРАВЕ И ПОЛИТИКЕ. ОТ ГЛАВНОГО РЕДАКТОРА АВТОРАМ И ЧИТАТЕЛЯМ ЖУРНАЛА RUSSIAN STUDIES IN LAW AND POLITICS
Authors: Bolshakova Valentina M. 
Published: May 2023

Вас встречает 4 номер научно-практического и общественно-политического рецензируемого журнала по праву и политологии Russian Studies in Law and Politics (Российский журнал по праву и политологии) за 2022 год.
2022 год был богат на представительские научные мероприятия, публикации фундаментальных теоретических и практических юридических исследований, а также интересные и острые социально-правовые и политические дискуссии, которые нашли свое отражение на страницах ведущих научных и общественно-политических изданий. Наш журнал не стал исключением, на его страницах в течение года издавались любопытные и глубокие исследовательские статьи, вызвавшие живой интерес различных категорий читателей: профессиональных юристов и специалистов в области политологии.
Представляемый номер знаковый для коллектива издателя, редакционной коллегии журнала и его читателей. Заданный издательством и редакцией журнала подход к сплошному предварительному экспертному изучению работ, их двойному слепому рецензированию соответствуют самым высоким международным стандартам. Этот подход, а также качество публикуемых материалов, обеспечили включение журнала в Перечень рецензируемых научных изданий, в которых должны быть опубликованы основные научные результаты диссертаций на соискание ученой степени кандидата наук, на соискание ученой степени доктора наук Высшей аттестационной комиссии при Минобрнауки России по состоянию на 20 декабря 2022 года по трем научным специальностям: 5.1.2. Публично-правовые (государственно-правовые) науки (юридические науки); 5.1.3. Частно-правовые (цивилистические) науки (юридические науки); 5.5.3. Государственное управление и отраслевые политики (политические науки).
Включение журнала в указанный перечень это показатель высокой оценки со стороны экспертного научного сообщества профессиональному труду редакции журнала и Научно-инновационного центра, деятельность которого по изданию многопрофильных научных журналов давно является знаком качества, как в России, так и за рубежом.
Тематика публикуемых статей и их структурная, содержательная, стилистическая, рубрикационная и смысловая направленность могут быть различными и нередко содержать в себе плюральные научно-теоретические, правоприменительные и политические мнения. Неизменным были и остаются редакционные требования к высокому научному качеству, оригинальности и новизне представляемых и публикуемых в журнале материалов.
В 2023 году редакция журнала ждет от потенциальных авторов фундаментальных, прикладных, эмпирических и обзорных исследований в области права и политики, а также научных сообщений о крупных научных мероприятиях и профессиональных рецензий на научные и учебные издания от ведущих отечественных и зарубежных ученых на русском и английском языке. Надеемся, что публикуемые материалы будут полезны читателям и позволят и дальше популяризовать в обществе и использовать научные знания в практике.
Prevalence and molecular characterization of Entamoeba moshkovskii in diarrheal patients from Eastern India
Authors: Sardar Sanjib K. , Ghosal Ajanta , Haldar Tapas , Maruf Maimoon , Das Koushik , Saito-Nakano Yumiko , Kobayashi Seiki , Dutta Shanta , Nozaki Tomoyoshi , Ganguly Sandipan 
Published: May 2023

Background
Importance of the amphizoic amoeba Entamoeba moshkovskii is increasing in the study of amoebiasis as a common human pathogen in some settings. Limited studies are found on the genetic and phylogenetic characterization of E. moshkovskii from India; hence remain largely unknown. In this study, we determined the prevalence and characterized the E. moshkovskii isolates in eastern India.

Methods
A three-year systemic surveillance study among a total of 6051 diarrhoeal patients from ID Hospital and BC Roy Hospital, Kolkata was conducted for E. moshkovskii detection via a nested PCR system targeting 18S rRNA locus. The outer primer set detected the genus Entamoeba and the inner primer pair identified the E. moshkovskii species. The 18S rRNA locus of the positive samples was sequenced. Genetic and phylogenetic structures were determined using DnaSP.v5 and MEGA-X. GraphPad Prism (v.8.4.2), CA, USA was used to analyze the statistical data.

Result
4.84% (95%CI = 0.0433–0.0541) samples were positive for Entamoeba spp and 3.12% (95%CI = 0.027–0.036) were infected with E. moshkovskii. E. moshkovskii infection was significantly associated with age groups (X2 = 26.01, P<0.0001) but not with gender (Fisher’s exact test = 0.2548, P<0.05). A unique seasonal pattern was found for E. moshkovskii infection. Additionally, 46.56% (95%CI = 0.396–0.537) were sole E. moshkovskii infections and significantly associated with diarrheal incidence (X2 = 335.5,df = 9; P<0.0001). Sequencing revealed that the local E. moshkovskii strains were 99.59%-100% identical to the prototype (GenBank: KP722605.1). The study found certain SNPs that showed a correlation with clinical features, but it is not necessarily indicative of direct control over pathogenicity. However, SNPs in the 18S rRNA gene could impact the biology of the amoeba and serve as a useful phylogenetic marker for identifying pathogenic E. moshkovskii isolates. Neutrality tests of different coinfected subgroups indicated deviations from neutrality and implied population expansion after a bottleneck event or a selective sweep and/or purifying selection in co-infected subgroups. The majority of FST values of different coinfected subgroups were <0.25, indicating low to moderate genetic differentiation within the subgroups of this geographical area.

Conclusion
The findings reveal the epidemiological significance of E. moshkovskii infection in Eastern India as the first report in this geographical area and expose this species as a possible emerging enteric pathogen in India. Our findings provide useful knowledge for further research and the development of future control strategies against E. moshkovskii.
Hand instrumentation provides improved tissue response over ultrasonic scaler and substantiates safe dental practice: An in vivo study in rats
Authors: de Almeida Juliano Milanezi , de Araujo Nathália Januario , Matheus Henrique Rinaldi , de Abreu Furquim Elisa Mara , Piovezan Bianca Rafaeli , Fiorin Luiz Guilherme , Ervolino Edilson 
Published: May 2023

Objective
The aim of this study was to evaluate the effectiveness of hand debridement (HD) versus ultrasonic dental scaler (UDS) for the treatment of experimental periodontitis (EP) in rats.

Material and methods
Thirty 3‐month‐old male rats were used. EP was induced around the mandibular first molars (right and left). Seven days after induction, the treatments with either HD (n = 30) or UDS (n = 30) were randomly performed in each molar. Euthanasia were performed at 7, 15, and 30 days after treatment. Histometric (percentage of bone in the furcation [PBF]), histopathological, and immunohistochemical (for detection of tartrate-resistant acid phosphatase [TRAP] and osteocalcin [OCN]). Parametric data (PBF and TRAP) was analyzed by One-way ANOVA followed by Tukey’s post-test. OCN was analyzed by Kruskal-Wallis followed by Student-Newman-Keuls post-test. The level of significance was 5%.

Results
Group HD presented higher PBF and lower TRAP-immunolabeling at 30 days as compared with UDS in the same period (p≤0.05). Group HD presented higher OCN immunolabeling at 30 days as compared with 7 and 15 days (p≤0.05). Persistent and exacerbated inflammatory process was observed in some specimens from group UDS at 30 days, as well as the bone trabeculae presented irregular contour, surrounded by many active osteoclasts.

Conclusion
Nonsurgical periodontal therapy with HD resulted in higher PBF and lower expression of TRAP as compared with UDS. Also, HD increased the expression of OCN over time.
Validation of a pre-established triage protocol for critically ill patients in a COVID-19 outbreak under resource scarcity: A retrospective multicenter cohort study
Authors: Donat Nicolas , Mellati Nouchan , Frumento Thibault , Cirodde Audrey , Gette Sébastien , Guitard Pierre Gildas , Hoffmann Clément , Veber Benoît , Leclerc Thomas 
Published: May 2023

Introduction
In case of COVID-19 related scarcity of critical care resources, an early French triage algorithm categorized critically ill patients by probability of survival based on medical history and severity, with four priority levels for initiation or continuation of critical care: P1 –high priority, P2 –intermediate priority, P3 –not needed, P4 –not appropriate. This retrospective multi-center study aimed to assess its classification performance and its ability to help saving lives under capacity saturation.

Methods
ICU patients admitted for severe COVID-19 without triage in spring 2020 were retrospectively included from three hospitals. Demographic data, medical history and severity items were collected. Priority levels were retrospectively allocated at ICU admission and on ICU day 7–10. Mortality rate, cumulative incidence of death and of alive ICU discharge, length of ICU stay and of mechanical ventilation were compared between priority levels. Calculated mortality and survival were compared between full simulated triage and no triage.

Results
225 patients were included, aged 63.1±11.9 years. Median SAPS2 was 40 (IQR 29–49). At the end of follow-up, 61 (27%) had died, 26 were still in ICU, and 138 had been discharged. Following retrospective initial priority allocation, mortality rate was 53% among P4 patients (95CI 34–72%) versus 23% among all P1 to P3 patients (95CI 17–30%, chi-squared p = 5.2e-4). The cumulative incidence of death consistently increased in the order P3, P1, P2 and P4 both at admission (Gray’s test p = 3.1e-5) and at reassessment (p = 8e-5), and conversely for that of alive ICU discharge. Reassessment strengthened consistency. Simulation under saturation showed that this two-step triage protocol could have saved 28 to 40 more lives than no triage.

Conclusion
Although it cannot eliminate potentially avoidable deaths, this triage protocol proved able to adequately prioritize critical care for patients with highest probability of survival, hence to save more lives if applied.
Greater increases in intratumoral apparent diffusion coefficients after chemoradiotherapy predict better overall survival of patients with cervical cancer
Authors: Holopainen Erikka , Lahtinen Olli , Könönen Mervi , Anttila Maarit , Vanninen Ritva , Lindgren Auni 
Published: May 2023

Purpose
To evaluate whether 1) the intratumoral apparent diffusion coefficients (ADCs) change during cervical cancer treatment and 2) the pretreatment ADC values or their change after treatment predict the treatment outcome or overall survival of patients with cervical cancer.

Methods
We retrospectively enrolled 52 patients with inoperable cervical cancer treated with chemoradiotherapy, who had undergone diffusion weighted MRI before treatment and post external beam radiotherapy (EBRT) and concurrent chemotherapy. A subgroup of patients (n = 28) underwent altogether six consecutive diffusion weighted MRIs; 1) pretreatment, 2) post-EBRT and concurrent chemotherapy; 3–5) during image-guided brachytherapy (IGBT) and 6) after completing the whole treatment course. To assess interobserver and intertechnique reproducibility two observers independently measured the ADCs by drawing freehand a large region of interest (L-ROI) covering the whole tumor and three small ROIs (S-ROIs) in areas with most restricted diffusion.

Results
Reproducibility was equally good for L-ROIs and S-ROIs. The pretreatment ADCs were higher in L-ROIs (883 mm2/s) than in S-ROIs (687 mm2/s, P < 0.001). The ADCs increased significantly between the pretreatment and post-EBRT scans (L-ROI: P < 0.001; S-ROI: P = 0.001). The ADCs remained significantly higher than pretreatment values during the whole IGBT. Using S-ROIs, greater increases in ADCs between pretreatment and post-EBRT MRI predicted better overall survival (P = 0.018).

Conclusion
ADC values significantly increase during cervical cancer treatment. Greater increases in ADC values between pretreatment and post-EBRT predicted better overall survival using S-ROIs. Standardized methods for timing and delineation of ADC measurements are advocated in future studies.
ANALISIS KINERJA BERDASARKAN PERBEDAAN REALITAS DAN TINGKAT KESULITAN TUGAS: STUDI KASUS PADA PERAKITAN REPETITIF
Authors: Theresia Clara , Angela Debora , Theopilus Yansen 
Published: May 2023

Perkembangan virtual reality serta penggunaannya dalam kehidupan tidak dapat terhindarkan. Dalam bidang industri manufaktur masih terdapat perbedaan hasil penelitian mengenai efek dari virtual reality terhadap aspek fisiologis. Penelitian ini bertujuan untuk mengetahui pengaruh realitas dan kesulitan task terhadap tingkat kinerja yang diukur melalui time completion, dan task completion serta pengaruhnya terhadap tingkat stress (diukur dengan Galvanic Skin Response) dan tingkat kewaspadaan (diukur dengan Psychomotor Vigilance Task). Penelitian ini melibatkan 28 orang partisipan dengan menggunakan rancangan between subject design yang terbagi menjadi variabel realitas (Virtual Reality, Real World) dan tingkat kesulitan tugas (berat, ringan). Pengolahan data secara statistika deskriptif dan uji pengaruh dengan menggunakan two-way ANOVA dilakukan pada setiap aspek yang diukur. Tidak ditemukan adanya pengaruh signifikan (p-value > 0,05) antara faktor realitas atau faktor kesulitan task terhadap tingkat kinerja, tingkat stress, maupun tingkat kewaspadaan. Perlu dilakukan penelitian lebih lanjut mengenai pengaruh virtual reality terhadap aspek kinerja dan fisiologis. Usulan rekomendasi penyesuaian diberikan untuk penggunaan dalam bidang industri dengan mempertimbangkan waktu pelatihan, gerakan yang diperlukan, serta tingkat keterampilan yang dibutuhkan. Abstract[Performance Analysis in Virtual Reality Based on Different Levels of Reality and Task Difficulty: Case Study on Repetitive Assembly] Virtual reality has already been used and implemented in many sectors. In the manufacturing field, research on this subject has been done for some time now, but there are still some variations regarding the effect of virtual reality on physiological aspects. This research aims to determine the effect of reality and task difficulty on performance level as measured by time and task completion, stress level by using Galvanic Skin Response and vigilance level (measured by Psychomotor Vigilance Task). There were 28 participants using between subject designs. Descriptive statistics and tests to check the influence of the two independent variables were done using Two-way ANOVA for all aspects considered. This research resulted in no influence (p-value >0,05) from either reality or task difficulty toward performance, stress level, or alertness. More research should be done to know if there are some influences from virtual reality to human aspects. Some recommendations were made to adjust the virtual environment usage in industrial sectors with some consideration about training period, types of movements, and the skills needed in that particular sector.Keywords: Virtual Reality; Stress; Alertness; Performance; Psychomotor Vigilance Task; Galvanic Skin Responses
Arnold Zweig und Magnus Hirschfeld (Berlin und Palästina)
Authors: Herzer-Wigglesworth Manfred 
Published: May 2023

Abstract
The poet Arnold Zweig and the sexologist Magnus Hirschfeld, two German-Jewish atheists, are compared in their views on the emancipation of Jews and homosexuals in the 20th century. Without knowing about each other, the two visited Palestine in 1932, where they grappled with Zionism and the idea of a Jewish state. Zweigʼs reflections on Palestine are expressed in his 1932 novel »De Vriendt kehrt heim,« while Hirschfeldʼs »Weltreise eines Sexualforschers,« published in 1933 in Swiss exile, formulated his ambivalent, ultimately negative attitude toward Zionism. Zweig lived and worked in Palestine, despite all his reservations, until the founding of the State of Israel. Hirschfeld, who was almost twenty years older, died in France in 1935. Hirschfeldʼs lifelong fight against the persecution of homosexuals was supported by Zweig in many ways, but in the last decades of Zweigʼs life, as a member of the Jewish community in East Berlin, he almost completely faded into the background of his cultural-political activities.
Gregorianisch, julianisch oder jüdisch? Die unterschiedlichen Kalendersysteme im Alltagsleben der Stadt Sluzk im Großfürstentum Litauen während des 17. und 18. Jahrhunderts
Authors: Cieśla Maria 
Published: May 2023

Abstract
This article examines the influence of different calendar systems on the coexistence of the Christian and Jewish population in the city of Slutsk in the early modern period. Various religious groups lived in Slutsk in present-day Belarus since the early 17th century. As a result, three different calendar systems determined the everyday life in the city: while the Gregorian calendar regulated the administration. The church year of the Orthodox majority was based on the Julian and the holidays of the Jewish residents on the Hebrew calendar. The inhabitants knew about the religious festivals of the other group, not at least because they affected the economic life of the whole city. Mutual consideration and a pragmatic approach to the various holidays enabled a largely conflict-free coexistence in everyday life. Occasional disputes are documented, when the common urban space is used for religious celebrations.
Judenschutz in gemischt-herrschaftlichen Kleinterritorien der fränkischen Reichsritterschaft
Authors: Porzelt Christian 
Published: May 2023

Abstract
The article deals with the general conditions of Jewish life in two Franconian noble territories in the 17th and 18th centuries. The two market villages of Küps and Mitwitz were divided between different lords. Their population included Jewish inhabitants as well as representatives of both Christian denominations. These villages are thus characteristic of the settlement structure of Jews in the pre-modern period. The settlement of Jewish families was, on the one hand, a privilege of the imperial nobility, with which they demonstrated their imperial status to the outside world. On the other hand, the spatial and lordly fragmentation offered opportunities for settlement among different rulers – a circumstance that Jewish actors deliberately incorporated into their actions. They were well informed about the ruling conditions and knew how to make effective use of the existing competitive situation in order to expand their scope of action.