bluuebunny/crossref_metadata_2025_split huggingface dataset:
A single-center, nonblinded, clinical trial comparing blood pressures before and after tourniquet application in healthy humans: A study protocol
Authors: Seigler Samuel W. , Quinn Kristen M. , Holman Heather L. , Kim Joshua Y. , Rajab Taufiek K. 
Published: January 2023

Introduction
Cardiac arrest is the leading cause of natural death in the United States, and most surviving patients suffer from neurological dysfunction. Although this is recognized as a problem, there have been very few changes to the cardiopulmonary resuscitation (CPR) procedure. Tourniquets have been recognized for their ability to increase truncal blood pressure and have been shown to improve CPR outcomes in animal models. However, the relationship between tourniquet application and blood pressure elevation has not been adequately explored in healthy human adults.

Objectives
The objective of this study is to demonstrate that bilateral, non-invasive, peripheral vascular occlusion in the thighs results in an increased proximal systolic blood pressure ≥ 10 mmHg.

Methods
This is a single-center, non-blinded clinical trial. Volunteers will be screened for eligibility at least 24 hours before the day of the trial. On the day of the trial, volunteers will undergo an informed consent process. If they choose to participate in the trial after informed consent, their baseline blood pressure will be measured. Volunteers will then have a Combat Application Tourniquet (CAT) applied to each thigh, and the windlasses will be tightened by IRB-approved personnel. Once no pulse can be felt in the lower extremity, blood pressure will be measured in the arm. This will be replicated three times, and the tourniquets will be loosened between trials to allow the volunteers to rest. Any complications that arise during the trial will be handled by the physician that is present.

Analysis
Changes in systolic blood pressure and diastolic blood pressure will be analyzed using a Shapiro-Wilk test. Then, a one-way repeated measures analysis of variance (ANOVA) will be performed with a Holm-Sidak post-hoc test to determine the mean differences. The significance level will be set to 5% for statistical significance.

Registry and registration number
Clinicaltrials.gov, NCT05324306.
Sex differences in left ventricular stroke work and cardiac power output per unit myocardium relate to blood pressure in apparently healthy adults
Authors: Lu Jing , Yin Lixue 
Published: January 2023

Background
Left ventricular stroke work per unit myocardium (LVSWM) and cardiac power output per unit myocardium (CPOM) are important measures of myocardial workload. The sex differences in the myocardial workload and its correlation with blood pressure remain largely unclear.

Objectives
The purpose of this study is to investigate the sex differences in LVSWM and CPOM, and to relate them to blood pressure in a cohort of apparently healthy adults.

Methods
The LVSWM and CPOM were estimated in 596 age- and heart rate-matched apparently healthy adults (298 men) using transthoracic echocardiography combined with cuff-measured brachial blood pressure. The data were compared between sexes, and the sex differences in LVSWM and CPOM were related to blood pressure.

Results
After adjustment for the blood pressure, the LVSWM and CPOM were higher in women than in men [75.0 (73.7–76.4) vs 64.9 (63.5–66.2) cJ/100g for LVSWM, and 912.4 (894.1–930.6) vs 780.2 (762.0–798.5) milliwatt/100g for CPOM, respectively; all P<0.001]. After adjustment for the LVSWM and CPOM, the mean systolic and diastolic blood pressure were 7.4 mm Hg and 5.2 mm Hg higher in men than in women, respectively (all P<0.001).

Conclusions
For any given blood pressure, the workload per unit myocardium is higher in apparently healthy women than in their male counterparts. A sex-specific definition of normal blood pressure with a relatively lower threshold for women can minimize the sex differences in the myocardial workload, which might reduce the potentially comparatively higher risk of heart failure in women.
Face, content, criterion and construct validity assessment of a newly developed tool to assess and classify work–related stress (TAWS– 16)
Authors: Roy Runalika , Sukumar Gautham Melur , Philip Mariamma , Gopalakrishna Gururaj 
Published: January 2023

Introduction
As work-stress, is associated with Non Communicable Diseases, and decreased work productivity, health and economic benefits are expected from periodic work-stress screening among employees using valid and reliable tools. Tool to Assess and classify Work Stress (TAWS– 16) was developed to overcome limitations in existing work-stress assessment tools in India. This study aims to test face, content, criterion and construct validity of TAWS– 16 in a sample of managerial-supervisory employees.

Methods
Nine domain experts rated face and content validity of TAWS– 16. Content validity was measured by Content Validity Indices (I-CVI, S-CVI) and Modified Kappa statistics. Empirical validity was tested by analysing data reported from 356 Information Technology (IT) professionals wherein Exploratory Factor Analysis was conducted for the assessment of Construct Validity. Self-reported data was collected in an unlinked and anonymous manner using a web-link, which was emailed to the study subjects, after initial introductory telephone or personal conversation. Criterion Validity was tested against stress sub-scale of DASS– 21. This study was approved by NIMHANS ethics committee.

Results
Findings revealed that TAWS– 16 has good face validity. The content validity is acceptable (CVI = 0.829). Construct Validity is appropriate as 60.8% of the total variance was explained by the factors identified in our study. Criterion Validity was moderate (Kappa Value 0.208) due to inappropriate work-stress instrument for comparison with TAWS– 16.

Conclusions
Overall, TAWS– 16 demonstrated good face, content and construct validity. It measures work-stressors, coping abilities and psycho-somatic symptoms associated with work-stress. We recommend use of TAWS– 16 for periodic screening and classification of work-stress among employees.
A comparison of two types of contrast media used in endoscopic retrograde cholangiopancreatography: A retrospective study
Authors: Matsuura Tomoharu , Hamaya Yasushi , Onoue Shunya , Tamura Satoshi , Ishida Natsuki , Yamade Mihoko , Tani Shinya , Iwaizumi Moriya , Osawa Satoshi , Furuta Takahisa , Sugimoto Ken 
Published: January 2023

Background
Post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP) is one of the most serious complications of ERCP. Various procedures can reduce the incidence of PEP, such as wire-guided cannulation, prophylactic pancreatic stent placement, and pretreatment anal insertion of NSAIDs. Recently, iso-osmolar contrast media (IOCM) have been used for ERCP in several hospitals to reduce the risk of PEP in Japan. However, the effect of IOCM is uncertain because few reports have examined IOCM in relation to PEP.

Aim
This study aimed to investigate the relationship between contrast media used and the incidence of PEP.

Methods
This retrospective study included all qualifying patients who had undergone ERCP at Hamamatsu University Hospital between January 2012 and January 2020. This study examined whether there was a difference in the onset of PEP between patients administered IOCM and high osmolar contrast medium (HOCM). Propensity score matching was used to analyze patient characteristics and ERCP procedures. Amidotrizoic acid was used as HOCM and iodixanol as IOCM.

Results
ERCP was performed on 458 patients, and 830 procedures were conducted. After propensity score matching, 162 patients from the amidotrizoic acid group and 162 patients from the iodixanol group were selected. The incidence of PEP was 10.5% (17) in the amidotrizoic acid group and 9.3% (15) in the iodixanol group (P = 0.71). Changes in serum amylase levels post- and pre-ERCP were 240.6 ± 573.8 U/L and 142.7 ± 382.1 U/L in the amidotrizoic acid and iodixanol groups, respectively (P = 0.072).

Conclusion
Iodixanol had no prophylactic effect on PEP and clinical outcomes.
A European Credit Council for Consistent and Informed Policymaking
Authors: Smoleńska Agnieszka 
Published: January 2023

Abstract
In Banque Providence Eric Monnet draws on the history of central banking to investigate the problem of insufficient democratic anchoring of monetary policy. It is a very timely contribution, especially as the choices that the central bankers will face in the near future are bound to get ever more political. This article discusses Monnet’s proposals to increase central bank legitimacy through common deliberation of monetary policy authorities and economic policymakers, in particular in relation to EU’s credit policy. I draw on the rich literature on interinstitutional accountability to identify conditions for such an EU Credit Council to be fit for purpose. I further identify two specific EU contexts where further deliberation would be particularly called for: the differentiated monetary and internal market (credit) policies and the Green Deal. With regard to the first, I show how an EU Credit Council could help deepen our understanding of the mutual impact of advancing EU banking integration and continued existence of multiple currency regimes. With regard to the second, I discuss clarifications and adjustments needed in the EU legal framework to ensure that further policy coordination on financing the transition within such a Credit Council would facilitate the achievement of EU’s sustainability goals.
Sexual precocity in the setting of parental use of a compounded testosterone cream: case report and review of the literature
Authors: Georges Elena , Cedarbaum Vanessa , Bisno Daniel Isaac , Marshall Ian 
Published: January 2023

Abstract

Objectives
Person-to-person transmission of transdermal testosterone – termed secondary exposure – is a rare but important cause of precocious puberty.

Case presentation
A 3.5-year-old male was evaluated for precocious puberty based on a 6 month history of penile growth, development of secondary sexual characteristics, and growth spurt. Total testosterone level was significantly elevated at 1,460 ng/dL with normal prepubertal gonadotropin levels. Further history revealed that the father had been using transdermal testosterone for about 1 year. Within 2 months of discontinuation, total testosterone level was 20 ng/dL.

Conclusions
Given the recent increase in transdermal testosterone prescriptions, clinicians must consider exogenous hormonal exposure as an etiology for precocious puberty. Prescribers should counsel their patients about the significant risk of secondary exposure.
Lathosterolosis: a rare cholesterol metabolism disorder with a wide range of clinical variability
Authors: Söbü Elif , Kaya Özçora Gül Demet , Görükmez Özlem , Şahinoğlu Bahtiyar 
Published: January 2023

Abstract

Objectives
Lathosterolosis is a rare autosomal recessive congenital disease that occurs due to homozygous or compound heterozygous mutations in the sterol C5-desaturase (SC5D) gene. We report a male patient with biallelic missense variant detected in the SC5D gene.

Case presentation
An eight-month-old male patient was referred to the department of paediatric neurology for status epilepticus. He had no remarkable dysmorphic features except micrognathia, ptotic ear and thin-stranded hair. Laboratory tests revealed an alanine aminotransferase level of 502 IU/L and an aspartate aminotransferase level of 279 IU/L; other biochemical test results were normal. The brain MRI revealed atrophic changes in both hemispheres. A decrease in the volume of brain stem and thin corpus callosum were noticeable. Whole exome sequencing was performed because of consanguineous marriage and sibling death in his medical history, and the encountered features were consistent with suspected neurometabolic disease in the cranial imaging and the presence of borderline psychomotor retardation. A biallelic missense variant, c.656T>C p.(Leu219Ser), was identified in the SC5D gene.

Conclusions
Lathosterolosis is a rare cholesterol metabolism disorder and can be presented with a wide range of clinical features by newly reported cases. Lathosterolosis should be considered in cases with cataracts, delayed neuromotor developmental milestones and high levels of liver enzymes.
Influence of heat input on hot cracking sensitivity of the EA395-9 filler metal
Authors: Yang Xingwang , Liu Fuguang , Shi Chunfeng , Liu Gang , Li Yong 
Published: January 2023

Abstract
Microcracks are always present in the deposited metal of 10MnNi2MoVA steel weld seam, which affects the safety of the power plant steam pipeline. It is important to investigate the effect of heat input on the hot cracking sensitivity of the EA395-9 weld metal. In this work, the deposition of the weld metal of EA395-9 was prepared, then the hot cracking tendency of the weld with the different heat input was analyzed and observed. The results show that the moderate welding heat input can help to avoid hot cracking.
Effects of potato (Solanum tuberosum L.)–Mucuna pruriens intercropping pattern on the agronomic performances of potato and the soil physicochemical properties of the western highlands of Cameroon
Authors: Tchapga Franck Junior Ngandjui , Chotangui Asafor Henry , Fouegag Maryline Temgoua , Mubeteneh Tankou Christopher 
Published: January 2023

Abstract
A field experiment was conducted at the teaching and research farm of the Faculty of Agronomy and Agricultural Sciences of the University of Dschang to investigate the effects of potato–Mucuna intercropping pattern on the agronomic performances of potatoes and the soil physicochemical properties in western highlands of Cameroon. The experiment design was a randomized complete block with three replications. The treatments included a pure potato stand (T1), pure Mucuna stand (T2), 1:1 (T3), 1:2 (T4), and 2:1 (T5) potato–Mucuna intercropping patterns. The results revealed that potato–Mucuna intercropping patterns had no significant effect (P > 0.05) on potato growth variables, soil physical properties, and the relative crowding coefficient. The highest potato yield (24,913 kg ha−1) and potato equivalent yield (81,513 kg ha−1) were obtained from the 1:1 intercropping pattern. The highest total LER (2.17) and the lowest (1.38) were obtained with 1:1 and 1:2 intercropping patterns, respectively. Area time equivalent ratio values were greater than 1 in 1:1 (1.46) and 2:1 (1.29) intercropping patterns. Mucuna proved to be the most aggressive and competitive species according to Ap and competitive ratio values except for the 1:2 intercropping pattern with K indicating a yield advantage in all intercropping patterns. 1:1 and 2:1 intercropping patterns gave the best C/N (13.94) and cation exchange capacity (36.12 meq 100 g−1), respectively. Late blight incidence was highest (16.88%) on potato sole crop stand and lowest (8.05%) on 1:2 intercropping pattern. Therefore, based on the findings of this experiment, 1:1 or 1:2 intercropping pattern could be recommended in potato–Mucuna intercropping system.
Contribution of Stable Crack Extension to Variable Amplitude Fatigue Crack Growth
Authors: Sunder R. 
Published: January 2023

Abstract
Variable-amplitude fatigue is invariably associated with periodic tensile overloads that can induce static crack extension component in addition to fatigue crack growth. A simple equation is proposed to account for the static crack growth component. The procedure is validated against fractographic evidence from a programmed load sequence. Accounting for static crack extension is likely to improve cycle-by-cycle crack growth modeling and may also explain scale effects.
Neonatal Deafening Selectively Degrades the Sensitivity to Interaural Time Differences of Electrical Stimuli in Low-Frequency Pathways in Rats
Authors: Sunwoo Woongsang 
Published: January 2023

AbstractWe examined the effect of neonatal deafening on frequency-specific pathways for processing of interaural time differences (ITDs) in cochlear-implant stimuli. Animal studies have demonstrated differences in neural ITD sensitivity in the inferior colliculus (IC) depending on the intracochlear location of intracochlear stimulating electrodes. We used neonatally deafened (ND) rats of both sexes and recorded the responses of single neurons in the IC to electrical stimuli with ITDs delivered to the apical or basal cochlea and compared them with acutely deafened (AD) rats of both sexes with normal hearing (NH) during development. We found that neonatal deafness significantly impacted the ITD sensitivity and the ITD tuning patterns restricted to apically driven IC neurons. In ND rats, the ITD sensitivity of apically driven neurons is reduced to values similar to basally driven neurons. The prevalence of ITD-sensitive apical neurons with a peak-shaped ITD tuning curve, which may reflect predominant input from the medial superior olivary (MSO) complex, in ND rats was diminished compared with that in AD rats (67%, AD vs 40%, ND). Conversely, monotonic-type responses rarely occurred in AD rats (14%) but were approximately equally as prevalent as peak-type tuning curves in ND rats (42%). Nevertheless, in ND rats, the ITD at the maximum slope of the ITD tuning curve was still more concentrated within the physiological ITD range in apically driven than in basally driven neurons. These results indicate that the development of high ITD sensitivity processed by low-frequency pathways depends on normal auditory experience and associated biases in ITD tuning strategies.
Parathyroid carcinoma with pancreatitis causing hypercalcaemic emergency treated with extracorporeal membrane oxygenation-assisted parathyroid resection
Authors: Toyoda Madoka , Suganuma Nobuyasu , Takahashi Akari , Masuda Taku , Goda Masami , Yoshida Tatsuya , Yukawa Norio , Yamanaka Shoji , Rino Yasushi , Masuda Munetaka 
Published: January 2023

Summary
Emergencies due to malignancies usually have a severe clinical course and require urgent treatment. These scenarios are dubbed ‘oncologic emergencies’. Parathyroid tumours often cause hypercalcaemia but not oncologic emergencies. We present a case of parathyroid carcinoma with severe hypercalcaemia and pancreatitis, resolved by surgical resection of the tumour assisted by extracorporeal membrane oxygenation (ECMO). A 66-year-old woman presented to our hospital because of haematuria. Laboratory findings were as follows: white blood cell count: 30 000, C-reactive protein: 17.7, calcium: 21.9, creatine kinase: 316, creatine kinase-myoglobin binding: 20, troponin I: 1415.8, amylase: 1046, lipase: 499, blood urea nitrogen: 57, and creatinine: 2.42. ECG was unremarkable. CT revealed a 4-cm low-density irregular tumour in the left lobe of the thyroid gland and severe pancreatitis. We diagnosed hypercalcaemia and pancreatitis due to parathyroid carcinoma. Volume expansion with isotonic saline was started immediately. Calcitonin, followed by denosumab, calcimimetic agents, and continuous hemodiafiltration were administered. The patient’s general condition worsened due to uncontrolled hypercalcaemia. Urgent tumour resection was planned, assisted with ECMO for cardiopulmonary support and surgical field venous pressure reduction. Tumour histology was suggestive of parathyroid carcinoma. Hypercalcaemia and the patient’s general condition improved gradually postoperatively. Hypercalcaemia is one of the oncologic emergency symptoms, commonly occurring because of lytic bone metastasis. However, reports about parathyroid carcinoma-causing life-threatening hypercalcaemia and pancreatitis are scarce; the fatality of this condition is estimated to be 30–70%. We report a case of survival of hypercalcaemia of malignancy.

Learning points

Parathyroid carcinoma is relatively rare and sometimes causes emergent conditions such as hypercalcaemia and severe pancreatitis.

General therapy for hypercalcaemia including aggressive saline dehydration, administration of furosemide, calcitonin, zoledronic acid, and evocalcet, and dialysis is sometimes ineffective for parathyroid carcinoma. Therefore, careful planning of therapy in case of exacerbation is important.

During an emergency, rapid surgical treatment despite high calcium level is the best potential therapeutic strategy.
Effect of recombinant glycodelin on spleen structure in case of allogeneic bone marrow cells introduction
Authors: Troynich Ya. N. , Loginova N. P. , Zamorina S. A. , Raev M. B. 
Published: January 2023

Objective. To study the effect of recombinant glycodelin (Mybiosource, Germany) on the morphofunctional state of the spleen in case of transplantation of the allogeneic red bone marrow cells to Wistar rats in dynamics of in vivo experiment. From the point of view of immunology, pregnancy is a physiologically conditioned state of the tolerance of mothers immune system to genetically foreign embryo. Glycodelin is a protein associated with pregnancy; it has an immunosuppressive effect and is perspective for medicine.
Materials and methods. The morphological picture of the organ was assessed; the following immunohistochemical indicators were studied: monoclonal antibodies to 1) CD68 for identification of macrophages, membrane staining; 2) Ki-67 for cells divided with mitosis and being in different phases of cellular cycle; 3) determination of macrophage colony-stimulating factor (M-CSF).
Results. When studying the histological slices of the spleen, it was shown that glycodelin against the background of allogeneic transplantation of the bone marrow contributes to the activation of immune system cells in the spleen, stimulates the proliferation of immune cells (Ki-67) and their differentiation that was manifested by an increase in the number of plasmacytes. By the end of the study, macrophage content is essentially reduced; eosinophil infiltration is verified that is an indirect positive sign of reaction to the transplant. Against the background of the bone marrow cells allotransplantation, there was observed an increase in M-CSF level in animals on the day 21st from the onset the experiment compared with the group of intact animals. Introduction of glycodelin against the background of BM cells allotransplantation caused the cancellation of this effect.
Conclusions. Thus, the action of glycodelin qualitatively determined the function of the spleen in direction of the development of a tolerant immune response to allogenate and excluded the development of severe post-transplantation complications.
Efficacy of enterosorption in treatment of Covid-19 in pregnant women
Authors: Romanovskaya A. V. , Mikhailova E. V. , Denisyuk N. E. , Tyapkina D. A. 
Published: January 2023

Objective. To optimize the treatment of pregnant women with a moderate form of COVID-19 by including a sorbent in complex therapy.
Materials and methods. Pregnant women (n = 87) with a gestational term of 30 weeks or more were divided into 2 groups. Group 1 (n = 42) received standard treatment for COVID-19. Group 2 (n = 45) received an additional preparation of colloidal silicon dioxide. The following endotoxemia indicators were assessed: concentrations of C-reactive protein (CRP), interleukin-6 (IL-6), medium mass molecules (MМM). The course of pregnancy and complications of childbirth were evaluated.
Results. At the peak stage of the disease, in patients of group 2 the level of МММ was 0,43 opt. units lower, CRP 7.1 mg / l lower, IL-6 2.3 ng / ml lower than in women of group 1.
Anemia, fetal growth retardation, threatening preterm birth, fetoplacental insufficiency, polyhydramnios and oligohydramnios was diagnosed rarely in group 2; the average fetal weight was 256 g more, the average fetal height was 2.4 cm more than in group 1. In group 2, there were fewer children with moderate and severe asphyxia.
Conclusions. The addition of colloidal silicon dioxide to the standard treatment of pregnant women with a moderate form of COVID-19 helps to reduce the level of endogenous intoxication, which is manifested by positive dynamics.