bluuebunny/crossref_metadata_2025_split huggingface dataset:
Understanding the Perspectives of Medical Interns on Resignation Decisions: Implications for Post-Graduate Medical workplace
Authors: Anuduang Nattapat , Choocheepwattana Panus , Savigamin Chatuthanai , Wanchaijiraboon Passakorn 
Published: June 2023

Abstract
Background Thailand's healthcare system has been expanded through policy changes, improved service planning, and complex care teams, yet the shortage and maldistribution of doctors remain a significant challenge, particularly in rural areas. While several interventions have been implemented to address the issue, little attention has been paid to newly graduated physicians.Objective This study aims to explore the challenges faced by this group during internship programs and how they inform decisions to resign, using data gathered from online surveys launched by the Medical Council of ThailandMethods The analysis of data from a national survey of recently graduated interns in Thailand, approved by the Chanthaburi Research Ethics Committee, was performed using basic descriptive statistics, Pearson correlation, and Spearman's rho correlation in SPSS Version 28.0.0.0,Results This study surveyed 2,431 recently graduated medical interns (84.8%) from 4 types of undergraduate medical education programs in Thailand, with 3.5% planning to resign, citing reasons such as low income, heavy workload, and poor working environment. Significant correlations were found between categorical and ordinal independent variables, such as undergraduate programs and expected salary, waiting time for scholarships, scholarship location, and interest in pursuing other careers, with the resignation plan of participants.Conclusion In conclusion, this study provides insight into the factors associated with internship resignations among newly graduated doctors in Thailand, highlighting the need for policy changes to address issues related to workload, income, and scholarship opportunities.
The role of project components for the acceptance of an inner city river restoration project in Bad Bergzabern, Germany
Authors: Weiß Sören Bo , Schilling Janpeter , Frör Oliver 
Published: June 2023

Abstract
The poor conditions of rivers worldwide make restoration an issue of great importance and urgency. The acceptance of restoration by society is crucial, however, the factors determining such acceptance are still poorly understood. In particular, the understanding of the complex interplay between the acceptance or rejection of specific project components and the acceptance of the overall project require further exploration. To address this research gap, we analyze a restoration project in Bad Bergzabern, Germany to (1) investigate the acceptance of the overall project and its components, and (2) explore why people accept or reject specific components. Three hundred and twenty-one in-person interviews were conducted and the factors of acceptance were analyzed using logistic regression. Our findings show that while acceptance of the overall project is generally high, many respondents reject one or more project components. Complementary social project components, like a playground, find less support than purely ecological components. Overall, our research shows that differences in the acceptance of components depend on individual concerns, the quality of communication, attachment to the site, and age. Our results contribute to a better understanding of preferences for river restoration projects and help water managers design restoration projects that are highly accepted by society.
The Effects of Curcumin on Brain-Derived Neurotrophic Factor Expression in Neurodegenerative Disorders
Authors: Radbakhsh Shabnam , Butler Alexandra E. , Moallem Seyed Adel , Sahebkar Amirhossein 
Published: June 2023

:
Brain-Derived Neurotrophic Factor (BDNF) is a crucial molecule implicated
in plastic modifications related to learning and memory. The expression of BDNF is highly
regulated, which can lead to significant variability in BDNF levels in healthy subjects.
Changes in BDNF expression might be associated with neuropsychiatric diseases, particularly
in structures important for memory processes, including the hippocampus and
parahippocampal areas. Curcumin is a natural polyphenolic compound that has great potential
for the prevention and treatment of age-related disorders by regulating and activating
the expression of neural protective proteins such as BDNF. This review discusses and
analyzes the available scientific literature on the effects of curcumin on BDNF production
and function in both in vitro and in vivo models of disease.
Advances in Pyrazoles Rings’ Syntheses by Heterogeneous Catalysts, Ionic Liquids,
and Multicomponent Reactions - A Review
Authors: Medjahed Nassima , Kibou Zahira , Berrichi Amina , Choukchou-Braham Noureddine 
Published: June 2023

Abstract:
Nitrogen heterocycles represent one of the most important units in modern organic
chemistry besides their wide existence broadly in natural products, pharmaceuticals, and
functional materials. Among these heterocycles, pyrazole, the molecule of the present work,
received much attention in organic synthesis because it delivers significant therapeutic and
biological values as it was found to be the core unit of many drugs, agrochemicals, and related
candidates. Due to this fact, the development of practical methodologies for the preparation
of pyrazoles has attracted the long-standing interest of synthetic chemists. Synthetic heterocyclic
chemistry using green methods has captivated many researchers in the recent past
due to its easy operation and environmentally friendliness. In this review, we summarized
systematic approaches for the synthesis of pyrazole derivatives via heterogeneous catalysis,
ionic liquid catalysis, and multicomponent reactions.
Green Extracts with Metal-based Nanoparticles for Treating Inflammatory Diseases: A Review
Authors: Singh Sonia , Sharma Khushi , Sharma Himanshu 
Published: June 2023

Abstract:Globally, high death rates and poor quality of life are caused mainly by inflammatory diseases. Corticosteroids, which may have systemic side effects and would enhance the risk of infection, are the common forms of therapy. The field of nanomedicine has created composite nanoparticles that carry a pharmacological carrier and target ligands for distribution to sites of inflammation with less systemic toxicity. However, their relatively large size often causes systemic clearance. An interesting approach is metal-based nanoparticles that naturally reduce inflammation. They are made not only to be small enough to pass through biological barriers but also to allow label-free monitoring of their interactions with cells. The following literature review discusses the mechanistic analysis of the anti-inflammatory properties of several metal-based nanoparticles, including gold, silver, titanium dioxide, selenium, and zinc oxide. Current research focuses on the mechanisms by which nanoparticles infiltrate cells and the anti-inflammatory techniques using herbal extracts-based nanoparticles. Additionally, it provides a brief overview of the literature on many environmentally friendly sources employed in nanoparticle production and the mechanisms of action of various nanoparticles.
Structure-guided Development of Novel Benzothiophene Derivatives as PLK1-PBD Inhibitors
Authors: Huang Daowei , Zhang Jing , Yang Xiaocong , Tan Xiangduan , Chai Tingting , Ma Lindeng , Zhao Bingyang , Chen Ying , Yang Jixia , Zhang Yue 
Published: June 2023

Background:
Polo-like kinase 1 (PLK1), a validated target for tumor therapy, plays a key role
in mitosis and is over-expressed in many tumors. In addition to its N-terminal kinase domain, PLk1 also
harbors a C-terminal polo-box domain (PBD).

Objective:
A candidate based on PLK1-PBD was developed as a promising compound for future development.

Methods:
Seventeen small molecule PLK1-PBD inhibitors were designed, synthesized and evaluated for
PLK1-PBD inhibitory activities by fluorescence polarization (FP) assay. The compounds with better inhibitory
activities were further assessed for their anti-proliferative activities using a CCK-8 method.

Results:
The inhibitory rates of compounds 7a, 7d, 14a, 14d, 14e and 14f exceeded 98%. The IC50 values
of compounds 7d, 14d, 14e, and 14f were 0.73 μM, 0.67 μM, 0.89 μM and 0.26 μM, proving better than
MCC1019. Compound 14f showed the best inhibitory activity (IC50: 0.26 μM) and antiproliferative activities
against three cancer cell lines (HeLa, HepG2 and MG63). Especially, compound 14f also exhibited
acceptable safety profiles in the human ether-a-go-go related gene (hERG) and normal cell tests. The
results of docking and prediction studies indicated that compound 14f had a high binding affinity to the
target, with good drug-like absorption, distribution, metabolism, elimination, and toxicity (ADMET)
properties.

Conclusion:
Compound 14f can be a promising compound for future development.
Associations between HbA1c Reduction and Change in Depressive
Symptoms following Glucose-lowering Treatment in Adults: A Systematic
Review of Intervention Studies
Authors: Schmitt Andreas , Beran Magdalena , Geraets Anouk , Iversen Marjolein M. , Nefs Giesje , Nouwen Arie , Pouwer Frans , Huber Jörg W. , Schram Miranda T. 
Published: June 2023

Introduction:
Hyperglycemia constitutes a likely pathway linking diabetes and depressive symptoms;
lowering glycemic levels may help reduce diabetes-comorbid depressive symptoms. Since randomized
controlled trials can help understand temporal associations, we systematically reviewed the evidence regarding
the potential association of hemoglobin HbA1c lowering interventions with depressive symptoms.

Methods:
PubMed, PsycINFO, CINAHL, and EMBASE databases were searched for randomized controlled
trials evaluating HbA1c-lowering interventions and including assessment of depressive symptoms published
between 01/2000–09/2020. Study quality was evaluated using the Cochrane Risk of Bias tool. PROSPERO registration:
CRD42020215541.

Results:
We retrieved 1,642 studies of which twelve met our inclusion criteria. Nine studies had high and three
unclear risks of bias. Baseline depressive symptom scores suggest elevated depressive symptoms in five studies.
Baseline HbA1c was <8.0% (<64mmol/mol) in two, 8.0–9.0% (64–75mmol/mol) in eight, and ≥10.0%
(≥86mmol/mol) in two studies. Five studies found greater HbA1c reduction in the treatment group; three of
these found greater depressive symptom reduction in the treatment group. Of four studies analyzing whether the
change in HbA1c was associated with the change in depressive symptoms, none found a significant association.
The main limitation of these studies was relatively low levels of depressive symptoms at baseline, limiting the
ability to show a lowering in depressive symptoms after HbA1c reduction.

Conclusions:
We found insufficient available data to estimate the association between HbA1c reduction and
depressive symptom change following glucose-lowering treatment. Our findings point to an important gap in
the diabetes treatment literature. Future clinical trials testing interventions to improve glycemic outcomes might
consider measuring depressive symptoms as an outcome to enable analyses of this association.
An Insight into the Potential of Flavonoids and Furanocoumarins in the Treatment of Psoriasis
Authors: Singh Aanchal , Srivastava Nimisha 
Published: June 2023

Abstract:Psoriasis is a hereditary, immune-mediated illness that can affect the skin, joints, or both. The condition frequently requires the treatment of a wide group of specialists with a variety of specialties. Numerous difficulties are presented by psoriasis, such as its high prevalence, chronicity, disfigurement, disability, and related comorbidities. Natural treatment of psoriasis can be provided by flavonoids and furanocoumarins. Flavonoids, a group of chemical compounds with various phenolic structures, are found in a wide variety of foods, including fruits, vegetables, cereals, bark, roots, stems, flowers, tea, and wine. The health benefits of these natural compounds are well known, and efforts are being made to extract the components known as flavonoids. Furanocoumarin is a subgroup of coumarins with phenolic compounds. It can be divided into two groups: linear generic name psoralens, which include psoralen, xanthotoxin, and bergapten, and angular generic name angelicins, which include sphondin and pimpinellin. The most important plant source is psoralen, which has been used for generations in traditional medicine to treat psoriasis and vitiligo. The creation of alternative psoralen molecules that do not generate the bifunctional adducts that serve as the foundation for DNA crosslinking is one of the future directions for further improving psoriasis treatment. This article focuses on flavonoid and furanocoumarin research and development trends, modes of action, functions, and applications.
Anti-viral Application of Ganoderma lucidum in COVID-19
Authors: Shakeri Fatemeh , Babavalian Hamid , Moghimi Hamid , Afsharian Mahsa Pahlevan , Alipashazadeh Aida , Izadi Sahar Zuhuriyan 
Published: June 2023

Abstract:Ganoderma lucidum (Lingzhi), a common medicinal fungus, has been utilized in China since ancient times for health promotion and longevity. It has anti-inflammatory, antiviral, antitumor, antioxidant, and antiallergic activities. The antioxidant and immunomodulatory effects of this mushroom have shown promising impacts in the treatment of some viral diseases. COVID-19 is a life-threatening disease caused by SARS-CoV-2 that has recently been pandemic. Modern medicines have not been very efficient in the direct treatment of these viral infections, and although vaccination is effective in preventing viral infections, the incidence of acute respiratory infection can be reduced only slightly. Thus, alternative therapies are required, and in this regard, stimulating the immune system can be an effective way to prevent these infections. This study reports the potential of natural fungus-derived compounds that can possibly be used to fight SARS-CoV-2 infections.
Metanarration of Islamophobia through Houellebecq's Soumission
Authors: Artanti Yeni 
Published: June 2023

The persistent conflict resulting from distinctions in our diverse world are sustained by suspicion and fear in public life, yet cultural products offer insights into societal issues, highlighting the significance of mutual respect and authentic freedom. This study examined Soumission (2015) by Houellebecq as its main data source to trace Islam and deconstruct intertextually its misconceptions in the novel. This study uses qualitative research steps in literary studies, namely by reading many times data sources, making notes, grouping data thematically, and analyzing it inductively. Results showed that in this novel, Islam is portrayed as a threatening, frightening, ambiguous religion that favors a patriarchal system that places women in a subordinate position. Based on an examination of the Quran and Hadith of Islam reveals that Islam is a peaceful religion that respects its adherents and provides them with clear instructions on what is right and wrong, prohibited and permitted. Critical readers have the right to question the portrayal of Islam in this work if it aims to ridicule religious individuals, particularly Muslims, necessitating a prudent response to counter the author's deception. Keywords: déconstruction, laïcité, metanarration, politique, satire
Association of Depressive Symptom Trajectory With Physical Activity Collected by mHealth Devices in the Electronic Framingham Heart Study: Cohort Study
Authors: Wang Xuzhi , Pathiravasan Chathurangi H , Zhang Yuankai , Trinquart Ludovic , Borrelli Belinda , Spartano Nicole L , Lin Honghuang , Nowak Christopher , Kheterpal Vik , Benjamin Emelia J , McManus David D , Murabito Joanne M , Liu Chunyu 
Published: June 2023

Background
Few studies have examined the association between depressive symptom trajectories and physical activity collected by mobile health (mHealth) devices.

Objective
We aimed to investigate if antecedent depressive symptom trajectories predict subsequent physical activity among participants in the electronic Framingham Heart Study (eFHS).

Methods
We performed group-based multi-trajectory modeling to construct depressive symptom trajectory groups using both depressive symptoms (Center for Epidemiological Studies-Depression [CES-D] scores) and antidepressant medication use in eFHS participants who attended 3 Framingham Heart Study research exams over 14 years. At the third exam, eFHS participants were instructed to use a smartphone app for submitting physical activity index (PAI) surveys. In addition, they were provided with a study smartwatch to track their daily step counts. We performed linear mixed models to examine the association between depressive symptom trajectories and physical activity including app-based PAI and smartwatch-collected step counts over a 1-year follow-up adjusting for age, sex, wear hour, BMI, smoking status, and other health variables.

Results
We identified 3 depressive symptom trajectory groups from 722 eFHS participants (mean age 53, SD 8.5 years; n=432, 60% women). The low symptom group (n=570; mean follow-up 287, SD 109 days) consisted of participants with consistently low CES-D scores, and a small proportion reported antidepressant use. The moderate symptom group (n=71; mean follow-up 280, SD 118 days) included participants with intermediate CES-D scores, who showed the highest and increasing likelihood of reporting antidepressant use across 3 exams. The high symptom group (n=81; mean follow-up 252, SD 116 days) comprised participants with the highest CES-D scores, and the proportion of antidepressant use fell between the other 2 groups. Compared to the low symptom group, the high symptom group had decreased PAI (mean difference –1.09, 95% CI –2.16 to –0.01) and the moderate symptom group walked fewer daily steps (823 fewer, 95% CI –1421 to –226) during the 1-year follow-up.

Conclusions
Antecedent depressive symptoms or antidepressant medication use was associated with lower subsequent physical activity collected by mHealth devices in eFHS. Future investigation of interventions to improve mood including via mHealth technologies to help promote people’s daily physical activity is needed.
Measuring the Potential Effects of Mirror Therapy Added to the Gold Standard Facial Neuromuscular Retraining in Patients With Chronic Peripheral Facial Palsy: Protocol for a Randomized Controlled Trial
Authors: Dagenais Frédéric , Neville Catriona , Desmet Liesbet , Martineau Sarah 
Published: June 2023

Background
Facial neuromuscular retraining (fNMR) is a noninvasive physical therapy widely used to treat peripheral facial palsies. It consists of different intervention methods that aim to reduce the debilitating sequelae of the disease. Recently, the use of mirror therapy in the acute facial palsy and postsurgical rehabilitation contexts has shown promising results, suggesting its use as an adjunct to fNMR in treating patients with later stages of paralysis, such as the paretic, early, or chronic synkinetic.

Objective
The main aim of this study is to compare the efficacy of an added mirror therapy component with fNMR in patients with peripheral facial palsy (PFP) sequelae in 3 different stages. The specific objectives of this study are to measure the effects of combined therapy compared to fNMR alone on (1) participants’ facial symmetry and synkinesis, (2) quality of life and psychological aspects of the participants, (3) motivation and treatment adherence, and (4) different stages of facial palsies.

Methods
This study is a randomized controlled trial that compares the effect of fNMR combined with mirror therapy (experimental group: n=45) with fNMR alone (control group: n=45) in 90 patients with peripheral facial palsy presenting with sequelae 3-12 months after onset. Both groups will receive 6 months of rehabilitation training. Facial symmetry and synkinesis; participants’ quality of life; and their psychological factors, motivation, and compliance will be assessed at baseline (T0), 3 months (T1), 6 months (T2), and 12 months (T3) postintervention. Outcome measures are (1) changes in facial symmetry and synkinesis assessed with facial grading tools, (2) quality of life changes with patient questionnaires, and (3) therapy motivation with a standardized scale, as well as adherence to treatment with metadata. Changes in facial symmetry and synkinesis will be judged by 3 assessors blinded to group assignment. Mixed models and Kruskal-Wallis, chi-square, and multilevel analyses will be conducted according to the appropriate variable type.

Results
Inclusion will start in 2024 and is anticipated to be completed in 2027. The 12-month follow-up will be completed with the last patient in 2028. We expect patients included in this study to experience improvement in facial symmetry, synkinesis, and quality of life, regardless of group assignments. A potential benefit of mirror therapy for facial symmetry and synkinesis could be noted for patients in the paretic phase. We hypothesize better motivation and adherence to treatment for the mirror therapy group.

Conclusions
The results of this trial may provide new guidelines for PFP rehabilitation with patients dealing with long-term sequelae. It also fills the need for robust evidence-based data in behavioral facial rehabilitation.

International Registered Report Identifier (IRRID)
PRR1-10.2196/47709
The potency of kitolod leaves (Hipobroma longiflora) as traditional medicine for conjunctivitis during the COVID-19 pandemic: a brief review
Authors: Yuliana  , Ni Made Ersi Dwitami Barsua  , Made Wulan Virgioni Putri  , I Nyoman Satya Mahayana Putra  
Published: June 2023

During the coronavirus disease 2019 (COVID-19) pandemic, most activities have transformed into digital ones, including computer usage. The digital screen on the computer has blue light radiation which can activate inflammatory cytokines of the eye surface and cause various disorders including includes conjunctivitis. Kitolod leaves (Hippobroma longiflora) have been used traditionally to treat conjunctivitis. This paper aimed to describe the potency of kitolod leaves for conjunctivitis. This is a narrative literature review using publications gathering from PubMed and Google Scholar published since 2013 with exclusion criteria were the animal studies. The keywords of COVID-19 pandemic, blue light, conjunctivitis, H. longiflora, traditional therapy were used. Boolean logic "AND" was used to find specific international scientific publications in PubMed. Forty selected publications were gathered, summarized and then narrated. The kitolod leaves contains bioactive substances i.e. flavonoids, alkaloids, and saponins which can inhibit S. aureus growth as the main cause of conjunctivitis. The mechanism of antibacterial of these bioactive substances through inhibition of nucleic acid synthesis, disruption of cytoplasmic membrane function, and inhibition of energy formation process. Kitolod leaves is potential to develop as traditional medicine for conjunctivitis. However, further studies are required to obtain the best standardized extract and to evaluate its clinical efficacy and safety.