bluuebunny/crossref_metadata_2025_split huggingface dataset:
A female sterilization method for use in field-based behavioral studies of the invasive Asian longhorned beetle (Anoplophora glabripennis)
Authors: Chandler Jennifer L , Trotter Robert Talbot 
Published: January 2025

Abstract
Asian longhorned beetle (Anoplophora glabripennis Motschulsky), a wood borer (Coleoptera: Cerambycidae) native to China, has been unintentionally and repeatedly introduced to North American and European landscapes as a stow-away in the wood packing material commonly used in international trade. Asian longhorned beetle causes extensive damage and mortality in multiple deciduous tree species and in response, countries in both North America and Europe have adopted policies of eradication. Models that integrate patterns of Asian longhorned beetle dispersal with records of infested trees are critical in optimizing survey and eradication efforts and tracking eradication progress. While these tools continue to be developed, they have been limited by the availability of experimental dispersal data. Existing data is restricted to observations made in the beetle’s native range in China or based on inference of dispersal in invaded landscapes. Direct observation of beetle dispersal behavior in invaded landscapes could provide critical behavioral information, but the experimental release of gravid females has been incompatible with eradication program efforts. To fill this knowledge gap, there is a need to identify field-portable methods of effectively sterilizing mated females that do not alter ovipositional behavior. Here, we present a protocol for cauterizing a beetle’s ovipositor to prevent successful oviposition. Results of lab trials demonstrate the efficacy of ovipositor cauterization in inhibiting successful oviposition without altering the egg-laying behavior of gravid Asian longhorned beetle females. This method enables research to inform models of beetle dispersal and infestation risk without adding to actual or perceived risk of exacerbating infestations in an eradication program.
Characterization of Chitinase 3-like protein 1 spatiotemporal distribution in human post-traumatic brain contusions and other neuropathological scenarios
Authors: Carabias Cristina Sánchez , Alves Victoria Cunha , Hernández Laín Aurelio , Lagares Alfonso 
Published: January 2025

Abstract
Chitinase 3-like protein 1 (CHI3L1) is emerging as a promising biomarker for assessing intracranial lesion burden and predicting prognosis in traumatic brain injury (TBI) patients. Following experimental TBI, Chi3l1 transcripts were detected in reactive astrocytes located within the pericontusional cortex. However, the cellular sources of CHI3L1 in response to hemorrhagic contusions in human brain remain unidentified. Hence, we examined a comprehensive collection of histologically defined acute and subacute human cerebral contusions with various surgical intervals using immunohistochemistry, validated through double immunofluorescence for markers such as GFAP, NeuN, MBP, and Iba-1, along with Fluoro-Jade C histofluorescence staining. CHI3L1 was found at meningeal interfaces, showing significant thickening of subpial glial plate. Paradoxically, CHI3L1-positive astrocytes were identified in neuroanatomical locations distant from hemorrhagic foci, where numerous eosinophilic ischemic neurons also exhibited CHI3L1 immunoreactivity. CHI3L1 immunostaining extended into white matter tracts and highlighted various phagocytic or activated microglia forms after delayed surgical decompressions. Given these findings, we advise against using CHI3L1 as a reactive astrogliosis marker due to its expression in multiple cell types, including astrocytes, neurons, oligodendrocytes, ependymocytes, leptomeningeal cells, microglia, and blood vessels. This non-selective response underscores the potential for CHI3L1 elevation patterns in biofluids to reflect the overall lesion burden extent.
Unraveling the metabolic heterogeneity and commonality in senescent cells using systems modeling
Authors: Li Gong-Hua , Li Yu-Hong , Yu Qin , Zhou Qing-Qing , Zhang Run-Feng , Weng Chong-Jun , Ge Ming-Xia , Kong Qing-Peng 
Published: January 2025

Abstract
Cellular senescence is a key contributor to aging and aging-related diseases, but its metabolic profiles are not well understood. Here, we performed a systematic analysis of the metabolic features of four types of cellular senescence (replication, irradiation, reactive oxygen species (ROS), and oncogene) in 12 cell lines using genome-wide metabolic modeling and meta-analysis. We discovered that replicative and ROS-induced senescence share a common metabolic signature, marked by decreased lipid metabolism and downregulated mevalonate pathway, while irradiation and oncogene-induced senescence exhibit more heterogeneity and divergence. Our genome-wide knockout simulations showed that enhancing the mevalonate pathway, by administrating mevalonate for instance, could reverse the metabolic alterations associated with senescence and human tissue aging, suggesting a potential anti-aging or lifespan-extending effect. Indeed, the experiment in Caenorhabditis elegans showed that administrating mevalonate significantly increased the lifespan. Our study provides a new insight into the metabolic landscape of cell senescence and identifies potential targets for anti-aging interventions.
Semitopology: a topological approach to decentralized collaborative action
Authors: Gabbay Murdoch J 
Published: January 2025

Abstract
We introduce semitopology, a generalization of point-set topology that removes the restriction that intersections of open sets need necessarily be open. The intuition is that points represent participants in a decentralized system, and open sets represent collections of participants that collectively have the authority to collaborate to update their local state; we call this an actionable coalition. Examples of actionable coalition include: majority stakes in proof-of-stake blockchains; communicating peers in peer-to-peer networks; and even pedestrians working together to not bump into one another in the street. Where actionable coalitions exist, they have in common that collaborations are local (updating the states of the participants in the coalition, but not immediately those of the whole system); collaborations are voluntary (up to and including breaking rules); participants may be heterogeneous in their computing power or in their goals (not all pedestrians want to go to the same place); participants can choose with whom to collaborate; and they are not assumed subject to permission or synchronization by a central authority. We develop a topology-flavoured mathematics that goes some way to explaining how and why these complex decentralized systems can exhibit order, and gives us new ways to understand existing practical implementations. Semitopology is also interesting in and of itself, having a rich and interesting theory that quickly deviates from standard accounts on topological spaces. It soon becomes clear that the most interesting semitopologies are rather ill-behaved from the usual viewpoint, as they are never Hausdorff. A notion of ‘transitive open sets’ (topens) becomes central to the story, as topens define subsets of participants who should decide the same value in a distributed system that tries to achieve consensus, and points are called ‘regular’ when they have a topen neighbourhood. The theory is then further developed by introducing intertwined points, closures, closed sets and two interesting characterizations of regularity.
Decreased lymph node estrogen levels cause nonremitting progressive experimental autoimmune encephalomyelitis disease
Authors: Anwar Shehata , Lin Po-Ching Patrick , Pacheco Lazaro , Imai Kazuhiro , Tan Zhengzhong , Song Ziyuan , Wakamatsu Yuki , Minamiya Yoshihiro , Cheng Jianjun , Ko CheMyong , Inoue Makoto 
Published: January 2025

Abstract
Estrogen, a steroid hormone synthesized by both gonadal and nongonadal tissues, plays a pivotal role in modulating immune responses, including reducing relapse rates in relapsing–remitting multiple sclerosis (MS). This study explored the expression of aromatase, the enzyme responsible for estrogen synthesis, in lymph nodes (LNs) and its potential role in the pathogenesis of MS using a mouse model. We utilized Cyp19-RFP mice where cells that express or have previously expressed the Cyp19 gene (encoding aromatase) are marked by red fluorescent protein (RFP). RFP was detected in the high endothelial venules of all morphologically identifiable LNs, indicating aromatase activity within these tissues. We discovered that LNs actively synthesize 17β-estradiol, but this activity declines with age. Targeted delivery of an aromatase inhibitor specifically to LNs induced an interferon-β-resistant experimental autoimmune encephalomyelitis (EAE) phenotype. This phenotype was accompanied by significant gray matter atrophy in the spinal cord. These findings underscore LNs as crucial sites of de novo 17β-estradiol production, potentially contributing to nonremitting EAE phenotypes. The observed decline in 17β-estradiol likely exacerbates MS pathogenesis in aging mice. Importantly, aromatase expression in human cervical LNs suggests that these sites may similarly contribute to estrogen synthesis in humans, potentially opening new avenues for understanding and treating MS.
Epistemic akrasia and treacherous propositions
Authors: Luzon Bar 
Published: January 2025

Abstract
I argue that one ought not be epistemically akratic. Although this position may look self-evident, it is hard to pin down exactly what's wrong with the akratic subject. Indeed, some philosophers argue that epistemic akrasia is permissible. The standard anti-akratic response focuses on the weird downstream implications of this state for action and assertion. This approach, however, is unsatisfactory, since it fails to explain the epistemic impermissibility of epistemic akrasia. Here, I argue that epistemic akrasia is impermissible on a purely epistemic basis. Doing so brings out the connection between positive epistemic statuses and truth: it is that connection that explains the fundamental impermissibility of epistemic akrasia.
An Insight Into Gastro Esophagal Reflux Disease And It Management To Alternative Medicine And Lifestyle Changes
Authors: Pradhan Sushilta , Sarkar Dr Bapi Ray 
Published: January 2025

Abstract

Objective
This paper's primary goal is to draw attention to the persistent issues GERD sufferers experience and the ways that contemporary medicine and technology are addressing the condition's treatment. This paper's primary goal is to present some traditional medicine, primarily Chinese medicine, and its treatments for this illness.

Methods
A literature survey was done using different search databases like SpringerLink, PubMed, Google Scholar, Science Direct, and Web of Science. Keywords ‘Gastroesophageal reflux disease’, and ‘Traditional Chinese medicine’ were used.

Key findings
The prevalence of GERD varies among populations and geographical places. It is more common in Western countries where obesity and nutrition are important lifestyle factors. However, obesity is becoming more commonplace worldwide due to changes in lifestyle, nutrition, and obesity rates.

Conclusion
This review discusses the use of Chinese medicine and lifestyle changes for treating GERD, despite the initial treatment of PPIs. Nonetheless, up to 50% of the patients say their reflux symptoms are still present. Traditional herbal decoctions, such as modified Xiaochaihu decoction, Sini Zuojin decoction, and Hewei Jiangni decoction, have been found to reduce and even eliminate GERD symptoms. However, there is limited research and evidence-based therapeutic trials.
An unusually severe case of shiitake mushroom dermatitis with features of drug reaction with eosinophilia and systemic symptoms
Authors: Ng Tristen Tze Wei , Wood Benjamin Andrew , Le Patricia 
Published: January 2025

Abstract
Shiitake mushroom dermatitis is a well-documented phenomenon in the literature seen after consuming raw or undercooked shiitake mushrooms (Lentinus edodes). However, systemic features resembling a drug reaction with eosinophilia and systemic symptoms (DRESS) are rare. We report a case of severe shiitake mushroom dermatitis with atypical systemic features resembling DRESS. A 51-year-old man presented with acute unilateral periorbital oedema and flagellate erythema with no obvious drug precipitants and was initially managed as allergic contact dermatitis in the emergency department. Further inquiry revealed a history of raw shiitake mushroom ingestion 48 h before the onset of symptoms, which led to a working diagnosis of shiitake mushroom dermatitis. Skin biopsies showed mixed spongiotic and interface inflammatory reactions with a perivascular lymphocytic infiltrate and marked eosinophilia supportive of shiitake mushroom dermatitis. Rheumatological causes of flagellate erythema and periorbital oedema were excluded from clinical and laboratory findings. The patient initially presented with apyrexia and mild eosinophilia but then developed pyrexia, hypereosinophilia, neutrophilia and transaminitis. He subsequently developed bilateral periorbital oedema with his flagellate erythema, both of which were resolved with topical and oral corticosteroids. However, there was a new widespread morbilliform eruption with dorsal oedema of his hands. A diagnosis of DRESS-like shiitake mushroom dermatitis was considered. The patient required a long course of oral prednisolone to achieve clinical and biochemical resolution of his symptoms. Our case underscores the importance of prompt recognition and management of shiitake dermatitis, especially when it presents with DRESS-like features.
The Faces of God’s Country: Christian Nationalism in the United States and the Implicit Association of Asian Faces with Foreignness
Authors: Seto Christopher H 
Published: January 2025

Abstract
Understanding the recent surge of discrimination and violence against Asian Americans requires careful inquiry into the beliefs underlying perceived Asian “foreignness” in the United States (USA). This study draws on over 88,000 geographically linked implicit association test (IAT) results to investigate the links between Christian nationalism and the implicit perception of Asian faces as foreign. Christian nationalism is strongly associated with heightened implicit perceptions of Asian foreignness among non-Asian IAT participants (including other minoritized ethno-racial groups), adjusting for relevant covariates. Karlson–Holm–Breen analysis suggests that the link between Christian nationalism and the implicit perception of Asian faces as foreign is partially mediated by believing that “true” Americans were born in the USA and speak English, highlighting some of the ways through which Christian nationalism is tied to racialized conceptions of American identity and belonging. Implications for the scholarship of Christian nationalism and racism are discussed.
The role of amylin, a gut–brain axis hormone, in metabolic and neurological disorders
Authors: Muhammad Tahir , Pastore Stephen F. , Good Katrina , Yu Wai Haung , Vincent John B. 
Published: January 2025

AbstractAmylin, also known as islet amyloid polypeptide (IAPP), is a pancreatic β‐cell peptide hormone involved in satiation and control food intake. It is also produced in smaller quantities by neurons, the gastrointestinal tract, and spinal ganglia. Numerous studies have revealed that patients with type 2 diabetes mellitus (T2DM) and cognitive deficits exhibit IAPP deposits in the pancreas, brain, and blood vessels. IAPP has also been shown to exert neuroprotective effects against Alzheimer's disease (AD) and cognitive impairments. The objective of this review paper is to provide recent information about the pathophysiological roles of IAPP in metabolic and in neurological disorders, and its potential as a druggable target. We have reviewed preclinical and clinical human and animal research studies of IAPP. We discuss the IAPP structure, its receptors, and its physiological functions in metabolism, satiation, adiposity, obesity, and in the brain. Then we discuss its role in metabolic and neurological disorders like diabetes, obesity, bone disorder, neurodegeneration, cerebrovascular disorders, depression, alcohol use disorder, epilepsy, and in ovarian cysts. Overall, this review provides information on the progress of research into the roles of IAPP and its receptor in food intake, energy homeostasis, glucose regulation, satiation, and its role in metabolic and neurological disorders making it a potential target for therapeutic approaches. This review also suggests that the utilization of rodents overexpressing human IAPP in neurodegeneration models may unearth some significant therapeutic potentials for neurological disorders.
Sleep-Associated Traits and Hearing Difficulties in Noise: A Bidirectional Mendelian Randomization Study
Authors: Liu Chunyan , Wu Xiaonan , Li Jin , Song Shan , Guan Jing , Wang Qiuju 
Published: January 2025

Objectives:
The aim of this study was to investigate the causal relationships between sleep-associated traits and hearing difficulties in noise (HDinN) by Mendelian randomization (MR) analysis.

Design:
Single nucleotide polymorphisms associated with chronotype, insomnia, sleep duration, daytime dozing or sleeping, and ease of getting up in the morning were extracted from European population genome-wide association study pooled data for bidirectional MR analysis. The MR-Egger regression, the inverse variance weighted technique, and the weighted median method were used for data analysis. The study was then expanded to include South Asian, East Asian, African, and Greater Middle Eastern populations.

Results:
MR analysis indicated that in European populations, ease of getting up in the morning is a protective factor for HDinN (odds ratio [OR] = 0.932, p = 4.22 × 10−5, p
FDR = 5.62 × 10−4), while shorter sleep duration was a risk factor (undersleepers: OR = 1.164, p = 0.002, p
FDR = 0.014). In addition, there was an indicative causal association between daytime dozing and HDinN (OR = 1.089, p = 0.046, p
FDR = 0.123). The conclusions were consistent in African populations (ease of getting up: OR = 0.696, p = 0.012, p
FDR = 0.041, sleep duration: OR = 0.677, p = 0.032 p
FDR = 0.091, daytime dozing: OR = 1.164, p = 0.002, p
FDR = 0.014). In the reverse direction, there was a significant causal association between HDinN and both chronotype (OR = 1.413, p = 0.011, p
FDR = 0.042) and ease of getting up in the morning (OR = 0.668, p = 1.75 × 10−5, p
FDR = 3.49 × 10−4) in European populations, with similar conclusions respectively reached in East Asian (OR = 1.085, p = 0.010, p
FDR = 0.045) and African populations (OR = 0.936, p = 0.002, p
FDR = 0.012). Furthermore, although not observed in European populations, exploratory studies in non-European populations suggested a potential association between insomnia and HDinN (East Asian: OR = 1.920, p = 0.011, p
FDR = 0.043, African: OR = 2.080, p = 0.004, p
FDR = 0.019, South Asian: OR = 1.981, p = 1.59 × 10−4, P
FDR = 0.002, Greater Middle Eastern: OR = 2.394, p = 0.002, p
FDR = 0.012), and vice versa (Greater Middle Eastern: OR = 1.056, p = 0.014, p
FDR = 0.044).

Conclusions:
This study identified a potential bidirectional causal relationship between sleep-associated traits and HDinN. However, the underlying mechanisms of the causal relationships reported here have yet to be elucidated.
From Sheep to Sling: Pediatric Injuries Due to Rodeo Mutton Bustin’
Authors: Schultz Rebecca J. , Amaral Jason Z. , Taylor Tristen N. , Diejomaoh Rioke M. , De Las Casas Valeria C. , Wall Jon C. , Rosenfeld Scott B. 
Published: January 2025

Background:
Mutton Bustin’ was developed as a safer alternative to rough stock rodeo events such as bull riding to allow kids to participate in the rodeo. Children hold on to the bareback of a running sheep until they fall, competing to see who can ride the longest. While reports of injuries due to other rodeo events are well described in the literature, there are no reports of Mutton Bustin’-associated injuries. We present a case series describing the injury patterns in Mutton Busters who presented to our institution.

Methods:
Pediatric patients presenting to a single tertiary pediatric hospital system from April 2011 to April 2023 with injuries related to participation in Mutton Bustin’ were identified for retrospective review. Review of the medical record was performed to identify patients and collect demographic information (sex, age at injury, race, BMI), injury characteristics, mechanism of injury, and treatment patterns.

Results:
We identified 20 patients (mean age 5.5±1.2 y, 55% female) presenting to our institution with Mutton Bustin’ injuries. The most common injury pattern was upper extremity fracture occurring in 18/20 (90%) cases. Three (15%) of patients required surgical intervention. No patients had complications related to their injuries.

Conclusions:
Our series demonstrates upper extremity fractures to be the most common injuries obtained while Mutton Bustin’ outlines patient education strategies to prevent future rodeo-related injuries.

Level of Evidence:
Level IV—prognostic case series
Prediction of EGFR mutation status and its subtypes in non-small cell lung cancer based on 18F-FDG PET/CT radiological features
Authors: Fan Yishuo , Liu Yuang , Ouyang Xiaohui , Su Jiagui , Zhou Xiaohong , Jia Qichen , Chen Wenjing , Chen Wen , Liu Xiaofei 
Published: January 2025

Purpose
Prediction of epidermal growth factor receptor (EGFR) mutation status and subtypes in patients with non-small cell lung cancer (NSCLC) based on 18F-fluorodeoxyglucose (18F-FDG) PET/computed tomography (CT) radiomics features.

Patients and Methods
Retrospective analysis of 201 NSCLC patients with 18F-FDG PET/CT and EGFR genetic testing was carried out. Radiomics features and clinical factors were used to construct a combined model for identifying EGFR mutation status. Mutation/wild-type models were trained in a training cohort (n = 129) and validated in an internal validation cohort (n = 41) vs an external validation cohort (n = 50). A second model predicting the 19/21 mutation locus was also built and evaluated in a subset of EGFR mutations (training cohort, n = 55; validation cohort, n = 14). The predictive performance and net clinical benefit of the models were assessed by analysis of the area under curve (AUC) of the subjects, nomogram, calibration curve and decision curve.

Results
The AUC of the combined model distinguishing EGFR mutation status was 0.864 in the training cohort and 0.806 and 0.791 in the internal vs external test sets respectively, and the AUC of the 19/21 mutation site model was 0.971 and 0.867 in the training cohort and internal validation cohort respectively. The calibration curves of the individual models showed better model predictions (Brier score <0.25). Decision curve analysis showed that the models had clinical application.

Conclusion
The combined model based on 18F-FDG PET/CT radiomics features combined and clinical features can predict EGFR mutation status and subtypes in NSCLC patients, and guiding targeted therapy, and facilitate precision medicine development.