bluuebunny/crossref_metadata_2025_split huggingface dataset:
Métodos y técnicas empleados en investigaciones teológicas latinoamericanas publicadas entre 2018 y 2020
Authors: Cardozo Juan Felipe , Rúa Penagos Jonathan Andrés 
Published: August 2023

El objetivo de este trabajo fue analizar cuantitativamente los métodos y técnicas de la investigación teológica en países latinoamericanos de habla hispana, entre 2018 y 2020, para el fomento de herramientas que favorezcan estudios en el área. El estudio fue cuantitativo, positivista y descriptivo, examinando el Scimago Journal & Country Rank (SJR) 2018, revisando, además, artículos publicados entre 2018 y 2020, nueve publicaciones de universidades que ofrecen el programa Teología, trabajos de grado y tesis en repositorios digitales. Para un total de 402 investigaciones sistematizadas, usando el análisis de contenido para discriminar métodos y técnicas utilizados. La información se registró en una matriz para su análisis porcentual por criterios. Se concluye que una quinta parte de las investigaciones usaron exclusivamente métodos sociales, en su mayoría de enfoque cuantitativo y nivel descriptivo. Entre los sociales cualitativos destacaron la fenomenología, IAP, método comparativo y biográfico. Se usaron mayoritariamente métodos teológicos tradicionales: hermenéutico, exegético, praxeológico latinoamericano e histórico-crítico, pero el primero sigue siendo preferido. Las técnicas fueron variadas, mezclando enfoques y métodos, especialmente reflexión, análisis semántico, análisis histórico-gramatical y narración. De las técnicas sociales, la favorita fue encuesta-cuestionario. El país con más publicaciones fue Colombia (45,7 %) y el año con mayor número de estas fue el 2018 (55 %). El enfoque predilecto fue cualitativo (87,1 %), usado mayoritariamente en universidades católicas (78,6 %). El resto (21,4 %) corresponde a universidades adventistas, con más igualdad en los enfoques.
Cytotoxic Flavokawain B Inhibits the Growth and Metastasis of Hepatocellular
Carcinoma through UCK2 Modulation of the STAT3/Hif-1α/VEGF
Signalling Pathway
Authors: Malami Ibrahim , Alhassan Alhassan Muhammad , Adamu Adamu Ahmed , Bello Muhammad Bashir , Muhammad Aliyu , Imam Mustapha Umar 
Published: August 2023

Background:
Hepatocellular carcinoma (HCC) is associated with a high mortality rate
due to early recurrence and its metastasis features. To this day, effective treatment options for metastatic
HCC remain a major challenge to patient treatment. Flavokawain B (FKB) is a naturally occurring
chalcone molecule capable of providing effective therapy against this life-threatening disease.

Objective:
This study investigated the anti-metastatic effects of FKB on the growth and development
of metastatic HCC.

Methods:
HepG2 cells were used in this study and a neutral red assay was performed to determine
the IC50 value of FKB. Cell scratch and exclusion zone assays were performed to assess the rate of
cell migration and invasion. Relative mRNA levels of UCK2, STAT3, VEGF and HIF-1α genes
were quantified using RT-qPCR.

Results:
FKB inhibited the proliferation of HepG2 cells at an IC50 value of 28 μM after 72 h of incubation.
Its cytotoxic effect was confirmed to induce apoptosis through the phase-contrast inverted
microscope. Cell migration and invasion were significantly inhibited at 7, 14, and 28 μM of
FKB as compared to untreated cells. The inhibition in the cell migration significantly increased
with the increasing concentrations of the bioactive compound. The relative expression levels of the
UCK2 gene and its downstream genes, STAT3, VEGF and HIF-1α, were significantly downregulated
after 72 h exposure to FKB treatment.

Conclusion:
Our data suggest that FKB inhibited HepG2 proliferation and further suppressed its
metastasis partly by regulating the STAT3/Hif-1α/VEGF signalling pathway. FKB could be a potential
alternative and viable strategy against HCC.
Sema3A Alleviates the Malignant Behaviors of Gastric Cancer Cells
by Inhibiting NRP-1
Authors: Yang Hongqiong , Zhou Yaojun , Wang Liangzhi , Lv Mengjia , Sun Jinling , Luo Zhenguo , He Junbo 
Published: August 2023

Aims and objectives:
Semaphorin3A (Sema3a) is lowly expressed in the
peripheral blood of gastric cancer patients, suggesting Sema3a may be involved in the
progression of gastric cancer. Nevertheless, the specific role and the potential regulatory
mechanism of Sema3a in gastric cancer is still obscure. Neuropilin-1 (NRP-1) has been
reported to interact with Sema3a; herein, we intended to reveal the role and regulatory
mechanism of Sema3a/neuropilin-1 (NRP-1) in gastric cancer progression.

Methods:
Cell transfection was carried out to regulate gene expression. CCK-8 and
colony formation assays were applied to estimate cell proliferation. Scratch assay and
transwell assay were conducted to assess the cell migration and invasion abilities.
Angiogenesis ability was assessed using a tubule-forming assay. The expression of
corresponding genes and proteins were detected by RT-qPCR and western blot,
respectively.

Results:
Data showed that Sema3a was downregulated in gastric cancer cells and
NRP-1 was upregulated. Sema3a overexpression repressed NRP-1 level in AGS cells.
Overexpression of Sema3a inhibited cell proliferation, migration, and invasion abilities as
well as epithelial-mesenchymal transition (EMT) of AGS cells. Overexpression of
Sema3a inhibited tube formation and reduced the expression of VEGFA/VEGFR2 in
AGS cells. However, the effects of Sema3a overexpression on the malignant behaviors
in AGS cells were partly reversed by NRP-1 overexpression. Additionally, Sema3a
overexpression enhanced the inhibitory effects of Ramucirumab, an anti-VEGFR2 agent,
on the proliferative, migratory, and invasive capabilities as well as EMT in AGS cells.

Conclusion:
In conclusion, Sema3a alleviates the proliferation, migration, invasion, and
angiogenesis capabilities of gastric cancer cells via repressing NRP-1. This finding may
provide potential targets for gastric cancer therapy.
Case Report and Literature Review of Multi-drugs Synergy and Targeted
Comprehensive Treatment in Advanced Hepatocellular Carcinoma
Authors: Lu Guanhua , Ou Limin , Cao Mingrong , Hu Min 
Published: August 2023

Background:
A 43-year-old female patient was found to have an abnormal liver function,
abnormally elevated alpha-fetoprotein and space-occupying lesions in the liver on routine
screening. The patient came to our hospital for further diagnosis and treatment.

Case presentation:
Investigations: Laboratory investigations, digital subtraction angiography (DSA)
of the hepatic artery, abdominal ultrasound examination, and magnetic resonance imaging (MRI)
scan were conducted using pathological staining and immunohistochemistry. Diagnosis: Clinical
diagnosis: cT3NxM0. Barcelona clinic liver cancer (BCLC) staging: BCLC stage C. China liver
cancer (CNLC) staging: CNLC IIIa.

Discussion:
The patient was hospitalized for the first time for transcatheter arterial chemoembolization
(TACE) and FOLFOX-based hepatic arterial infusion chemotherapy (HAIC). Then, the second
and third hospital admissions were given HAIC based on FOLFOX. Camrelizumab and oncolytic
virus were also injected into the liver cancer through the microcatheter in the first three treatments.
On the fourth admission, the patient’s indicators were improved, and the tumor shrank. Furthermore,
as the patient suffered adverse reactions the first few times, we suspended the treatment
of FOLFOX and the oncolytic virus. Before surgical treatment, lenvatinib was used throughout the
treatment. On the fifth admission, the patient underwent liver cancer resection.

Conclusion:
It proves the value of multiple combination therapy, which can provide guidance for patients with advanced hepatocellular carcinoma that cannot be surgically removed.
Effects of Antidepressants on Sleep in Post-traumatic Stress Disorder: An
Overview of Reviews
Authors: Lappas Andreas S. , Polyzopoulou Zoi A. , Christodoulou Nikos , Bozikas Vasilios-Panteleimon , Samara Myrto T. 
Published: August 2023

Abstract:
Antidepressants are a commonly used, easily accessible, and overall safe treatment option
for post-traumatic stress disorder (PTSD). The present review aims to evaluate the efficacy and safety
of antidepressants in treating sleep disturbances in patients with PTSD. PubMed and the Cochrane Library
were searched (July 2022) for systematic reviews and meta-analyses on the treatment of PTSD.
Moreover, PubMed and ClinicalTrials.gov were searched for individual trials investigating the antidepressant
treatment of PTSD (up to September 2022), and reference lists of all possibly relevant identified
studies were screened. Sleep-related outcomes, i.e., total sleep time, sleep quality, dreams/
nightmares, insomnia, and somnolence, were extracted independently by at least two reviewers. Metaanalytic
evaluations were performed wherever possible. 39 randomised controlled trials (RCTs) were
identified; data from pooled analyses, reviews, and observational studies were used for antidepressants
with a weak evidence base or when their findings were deemed important. Overall, scarce data exist
on the effects of antidepressants on sleep outcomes among patients with PTSD. Some evidence may
support the use of amitriptyline, nefazodone, paroxetine, and sertraline for improving sleep in patients
with PTSD. Τhere was a meta-analytical trend indicating improvement of nightmares with fluoxetine,
less insomnia with amitriptyline and more with brofaromine, as well as more somnolence with paroxetine
vs. placebo, respectively. However, data from more than 1 RCT with a considerable number of patients
were only available for paroxetine. Evidence is insufficient to draw safe conclusions. More and
better-designed RCTs, with consistent reporting of sleep-related outcomes, are needed.
Enantioselective Michael Addition of Cyclohexanone to Nitroolefins
Catalyzed by a New Pyrrolidinyl-isosteviol Bifunctional Organocatalyst in
Water
Authors: Liu Yu-Xia , Xu Yuan-Yuan , Li Shuai , Pan Zi-Qing , Li Bing-Xue , Fan Zhao-Yang 
Published: August 2023

Abstract:
A new pyrrolidinyl-isosteviol bifunctional organocatalyst was synthesized, which was applied
to catalyze the asymmetric Michael addition between cyclohexanone and nitroolefins. With 10
mol % of the organocatalyst, the reaction proceeded in water in high yields (up to 99%) with excellent
diastereoselectivities (anti/syn up to 98:2) and good enantioselectivities (up to 90% ee). The design of
the proline-isosteviol conjugates as organocatalysts was based on the crucial role of proline in the
formation of enamine. To sum up, a new pyrrolidinyl-isosteviol bifunctional organocatalyst was synthesized,
which could effectively catalyze the C-C formation reaction between a number of nitroolefins
and cyclohexanone.
Exploring Novel PLK1 Inhibitors based on Computational Studies of
2,4-Diarylaminopyrimidine Derivatives
Authors: Yang Honghao , Zhao Yilan , Zheng Xiaojiao , Ju Xiulian , Wu Fengshou , Luo Xiaogang , Sun Qi , Liu Genyan 
Published: August 2023

Background:
Polo-like kinase 1 (PLK1) is an important target for anti-cancer drugs. A series
of novel 2,4-diarylaminopyrimidine derivatives (DAPDs) as PLK1 inhibitors (PLKIs) with remarkable
activities have been reported recently.

Methods:
A systemically computational study was performed on these DAPDs, including threedimensional
quantitative structure-activity relationship (3D-QSAR) modeling, molecular docking, and
molecular dynamics (MD) simulation.

Results:
The constructed 3D-QSAR models exhibited reliable predictability with satisfactory validation
parameters. The dockings revealed the binding modes of DAPDs in PLK1 protein, and two key residue,
Cys133 and Phe183, could interact with DAPDs by hydrogen bonds and π-π stacking, which might be
significant for the activity of these PLKIs. Eight compounds with higher predicted activity than the most
active DAPD-compound (16) were designed based on the 3D-QSAR models. These newly designed compounds
also exhibited higher docking scores than compound 16 in the binding pocket of PLK1. The
ADME predictions and MD simulations further indicated that two hit compounds with reasonable pharmacokinetics
properties could stably bind with PLK1 and have the potential to become novel PLKIs.

Conclusion:
Two newly designed compounds might have the potential to be novel PLKIs. These results
might provide important information for the design and development of novel PLKIs.
Efficacy of Osimertinib Continuation Plus Metronomic Oral Vinorelbine for EGFRmutant
Advanced NSCLC Beyond Limited Progression on Osimertinib
Authors: Li Meifang , Lin Cheng , Lin Jinghui , Chen Shijie , Weng Lihong , He Zhiyong 
Published: August 2023

Background:
Treatment options for advanced non-small-cell lung cancer (NSCLC) after osimertinib failure
are limited, and osimertinib continuation is recommended for selected patients. Metronomic oral vinorelbine is an
effective treatment with less toxicity for advanced NSCLC.

Objective:
The objective of the study was to investigate the effects of osimertinib plus metronomic oral vinorelbine on
epidermal growth factor receptor (EGFR)-mutant advanced NSCLC beyond limited progression on osimertinib.

Methods:
We have reviewed the medical records of 28 patients with EGFR-mutant advanced NSCLC who had received
osimertinib continuation plus metronomic oral vinorelbine beyond limited progression on osimertinib. We also
evaluated the clinicopathological characteristics of enrolled patients, as well as the efficacy and toxicity of the treatment

Results:
After a median follow-up period of 14.1 months, 57.1% (16/28) of cases showed NSCLC progression. The
median progression-free survival (PFS) period under osimertinib plus metronomic oral vinorelbine was 9.4 months
(95% confidence interval, 1.562–17.238 months), with a disease control rate of 89.3% and objective response rate of
17.9%. PFS did not differ between patients who had previously received osimertinib as first- (n = 16) and second-line
(n = 12) therapy (median, 11.4 and 4.7 months, P = 0.391). In addition, the median PFS duration did not differ according
to the efficacy (PFS2 ≥ 6 months vs. < months) of previous osimertinib monotherapy (median, 5.8 and 9.4
months, P = 0.677).

Conclusions:
Osimertinib continuation in conjunction with metronomic oral vinorelbine may enable overcoming TKI
resistance and prolong the survival of patients with EGFR-mutant advanced NSCLC beyond limited progression on
osimertinib treatment
A Study on Psychological Impact of Working From Home of Employees during COVID-19 Pandemic- a Cross Sectional Study
Authors: Dondapati Sumedha , S. Iniyan , B. Ajay , R. Maathanghi , P. Kavitha 
Published: August 2023

Introduction:
With the sudden onset of COVID 19, many organisations introduced
a mandatory relocation of workforce from their workplace to their homes bringing in a work
from home policy for their employees. The purpose of the study is to examine the positive and
negative impact on quality of life of teleworking, thereby assessing the prevalence of psychological
distress of employees working in COVID 19.

Methods:
A cross sectional study was conducted on Indian - representative survey of selfreported
data through an online questionnaire of work from home employees and their responses
were analysed using SPSS software.

Results:
The study findings revealed that out of 2943 total respondents to the questionnaires,
18.9% and 20.2% had agreed and strongly agreed respectively to the statement that, work from
home was a chance to break old habits and change routine. The mean positive affect score
among those affected with COVID was 20.82 ± 3.71 and for those not affected with COVID
was 21.12 ± 3.71.

Conclusion:
The results indicate age disparities in mental distress, perceived adversities highlighted
the discrepancies differed by the area of residence and those affected by the corona virus.
Study of Current Trends of Participation of Population of the BRICS and OECD Countries in the Global Online Labor Market
Authors: Galieva G. F. , Sazanova E. V. , Dik E. N. , Amineva R. R. 
Published: August 2023

The relevance of the study is the need to study current trends in the global online employment market in developed and developing countries in order to level out possible imbalances in the labor market in the context of digital development.The purpose of the study is to conduct a comparative analysis and identify the features of the participation of the population of the BRICS and OECD countries in the functioning of the global online labor market at the present stage, as well as to determine measures to ensure the balanced development of the traditional labor market in the implementation of new forms of online employment.The objectives of the study are to identify the level of formation of the basic conditions for the access of the population of some BRICS and OECD countries to the global online labor market; to determine trends in the participation of the population of the BRICS and OECD countries in the global online labor market; to form recommendations to ensure the balanced development of the traditional market in the conditions of the activation of the online labor market.Methodology. The study was conducted using the method of content analysis of information from open sources, methods of comparative and economic analysis. The results of data analysis are presented using systematization methods, tabular and graphical methods. The formation of recommendations is provided by the use of the logical method, as well as analysis and synthesis.Results. The gap in the level of formation of basic conditions for access to digital infrastructure between the BRICS and OECD countries has been revealed, which determines their differences in the use of the potential of the global online labor market. It has been established that the global online labor market is generally more preferable for employers from developed OECD countries and specialists from developing BRICS countries. The directions of expanding the possibilities of using the potential of the global online labor market for the BRICS and OECD countries are substantiated.Conclusion. The analysis confirmed the authors' assumption that there are significant differences between developed and developing countries in using the potential of public participation in the global online labor market.
Financial Management of an Industrial Enterprise in the Context of Digital Transformation
Authors: Krilova V. V. 
Published: August 2023

Relevance. Development of industrial enterprise changes constantly. It’s apparented in the different information technologies introduction. It’s let to participate in the digital economy project on the national and international market. Different changes in the industrial enterprise activities indicate in changes of financial recourses management in current time period and in perspective.The purpose is studying financial resources management in the industrial enterprise in digital transformation’s realization in current time period and in perspective. Objectives. Research objectives include studying kinds of financial recourses and their changes in the industrial enterprise; studying financial recourses management features in the industrial enterprise in digital transformation’s realization; forming digital transformation strategy stages in this enterprise and their impact on financial recourses.Methodology. It’s researched financial recourses management features in the industrial enterprise and their changes in digital transformation’s realization in current time period and in perspective for achieving the set goal. Results. It’s studied financial management features in the industrial enterprise. It’s researched features of digital transformation’s realization in the industrial enterprise for participating in digital economy. It’d formed features of financial management in the industrial enterprises in terms of digital transformation’s realization in current time period and in perspective. Conclusions. Financial management in terms of digital transformation let to accelerate different processes realization, to increase efficiency of this enterprise activities in the national and international market. It let to support desired level of this enterprise competitiveness.
State Financial Regulation of Innovations in Russia under International Sanctions
Authors: Dorofeev M. L. 
Published: August 2023

Relevance. One of the most vulnerable aspects of the development of the Russian economy is its technological and innovative component. This aspect of the Russian economy was tried to reanimate and increase its effectiveness after the 2008 crisis, in order to move from a raw material model of economic growth to a model of advanced technological development. In 2022, Russia has no choice but to carry out a structural transformation of the economy, for the success of which it is vital to intensify and increase the efficiency of innovation. In this regard, the role of state financial regulation of innovation activities for the transition period is increasing.The purpose of this study is to substantiate approaches to state financial regulation of innovative development of the economy in the context of international sanctions and to clarify specific conditions for intensifying innovations in the non-state sector of the economy.Objectives: review of the scientific literature on the impact of sanctions on the dynamics of innovative activity; analysis of innovative activity in Russia over the past 10 years; justification of the methods and instruments of state financial regulation of innovations in the current conditions for Russia.Methodology. The article uses methods of analysis and synthesis of information, an overview analysis of scientific literature, horizontal and graphic analysis of Rosstat data on the innovative development of Russia.Results. The results of the work was the systematization of methods and instruments of state financial regulation in the context of international sanctions, as well as the justification of specific conditions for the successful innovative development of Russia in the current geopolitical situation.Conclusion. The Government should use a standard set of financial incentives for innovation activity, but to develop the non-governmental sector and improve the effectiveness of innovation activities, it is also necessary to create additional conditions for creating a favorable institutional environment in which appropriate private initiatives will be possible.