bluuebunny/crossref_metadata_2025_split huggingface dataset:
Temporomandibular joint disorders prevalence and health-seeking preferences among Al-Madinah community: A prospective cross sectional study
Authors: Alolayan Albraa , Alsayed Shayma S. , Salamah Ruwaa M. , Ali Khadija M. , Alsousi Mashael , Elsayed Shadia 
Published: May 2023

Background: Painful temporomandibular joint disorders (TMDs) are of musculoskeletal origin and are considered the most common cause of non-odontogenic pain in the orofacial region. The purpose of this study was to investigate the prevalence and awareness of temporomandibular joint (TMJ) disorders in Almadinah Almunawwarah community. Methods: A prospective observational cross-sectional study with convenience sampling was conducted. The patients were selected from the dental college and the hospital at Taibah University in Al-Madinah, Saudi Arabia. A translated Arabic version of Fonseca's questionnaire was employed. The questionnaire asked about the participant's personal information, if they thought they had TMDs, and who to visit for therapy if necessary. These were followed by 10 items from Fonseca's questionnaire, each with a three-point scale. Results: The questionnaire was completed by 518 people. Females made up 57.1% of the participants. TMDs were present in 61% of the population, with varying degrees of severity. Males (44.3%) were less affected than females (55.7%). The difference, however, was not statistically significant (P = 0.354). Out of the 61% TMDs Positive patients, 74.1% had mild TMDs symptoms, while 20.8% and 5.1%, respectively, had moderate and severe TMDs symptoms (P = 0.05). The severity of the symptoms was unaffected by demographic data (P > 0.05). Only 40% seek care, with 64.6% selecting for a dentist or orofacial pain specialists for their management and 24.6% preferring for an orthopaedic specialist (P= 0.008). Conclusions: Participants from Al-Madinah had a greater prevalence of mild TMDs. The majority of the participants had no idea who to go to for treatment. The findings of this study highlight the importance of educational activities to enhance public awareness
Integration of single-cell RNA-Seq and CyTOF data characterises heterogeneity of rare cell subpopulations
Authors: Repapi Emmanouela , Agarwal Devika , Napolitani Giorgio , Sims David , Taylor Stephen 
Published: May 2023

Background: The simultaneous measurement of cellular proteins and transcriptomes of single cell data has become an exciting new possibility with the advent of highly multiplexed multi-omics methodologies. However, mass cytometry (CyTOF) is a well-established, affordable technique for the analysis of proteomic data, which is well suited for the discovery and characterisation of very rare subpopulations of cells with a wealth of publicly available datasets. Methods: We present and evaluate the multimodal integration of single cell RNA-Seq and CyTOF datasets coming from both matched and unmatched samples, using two publicly available datasets. Results: We demonstrate that the integration of well annotated CyTOF data with single cell RNA sequencing can aid in the identification and annotation of cell populations with high accuracy. Furthermore, we show that the integration can provide imputed measurements of protein markers which are comparable to the current gold standard of antibody derived tags (ADT) from CITE-Seq for both matched and unmatched datasets. Using this methodology, we identify and transcriptionally characterise a rare subpopulation of CD11c positive B cells in high resolution using publicly available data and we unravel its heterogeneity in a single cell setting without the need to sort the cells in advance, in a manner which had not been previously possible. Conclusions: This approach provides the framework for using available proteomic and transcriptomic datasets in a unified and unbiased fashion to assist ongoing and future studies of cellular characterisation and biomarker identification.
The association between the distance from the epicenter of the Haiti earthquake (2021) and medical diagnoses: A report from the field
Authors: Levy Einav , Alkan Michael , Shaul Sharon , Livni Gillerman Yael , Gidron Yori 
Published: May 2023

Background: Following the earthquake of August 2021 in Haiti, humanitarian agencies provided support to the local population. NATAN, a voluntary based non-governmental organization, had arrived in the field five days after the earthquake and provided medical support based on a mobile clinic in seven villages close to the epicenter of the earthquake. Methods: We conducted a cross-sectional study on data collected from 331 persons of concern, as part of ‘good clinical practice’. They received basic treatment such as antibiotics and minor surgical interventions following a diagnosis. The main variables that were collected in this intervention included demographic data, main diagnoses, and main treatments. We also examined the distance from the earthquake epicenter (DfE) and its effects on the diagnoses and treatments. Results: Several interesting findings were observed. A significant association between the DfE and the diagnoses was found, where within the group closest to the epicenter, the most prevalent diagnosis was internal medicine problems (40.3%). Conclusions: It is possible that since five days had passed since the earthquake, the expected diagnoses of traumatic injuries were reduced, leaving sub-acute problems to be diagnosed and treated. Finally, mental health symptoms and stress levels should be assessed systematically and with validated measures.
Assessment of work-related stress and burnout among clinical research occupations
Authors: Flores Luna Raul , De la Rocha Carmen , Cid López Marco Antonio , Venegas López Ivette , Gómez Méndez Sandra Carolina , López Romero Wendy , Alvarado García Brenda A. , Almeida Zarate Brandon A. , Mejía Morales Claudia 
Published: May 2023

Background: Burnout syndrome is included by the World Health Organization (WHO) in the International Classification of Diseases, and it has a direct impact on the health of workers and also on the performance of companies. In this work, we propose a comprehensive methodology for evaluating work stress and burnout in various occupations within a healthcare organization. Methods: The work stress questionnaire and the Maslach Burnout Inventory were administered to employees of 7 different occupations within a company. The effect of the stressors is established using Cohen's d test, as well as the relationship between the main stressors, burnout and occupation. Results: The results of the study indicated that medical service personnel had the highest levels of stress and burnout syndrome, but significant stress levels and burnout scores were also identified among finance, clinical operations, and marketing professionals. Conclusions: Stress and burnout can vary by department, team, or individual in a company. Based on the study, it was concluded that a single approach to assessing stress and burnout may not provide a complete understanding, in fact, a better alternative is to assess each occupation specifically.
Control study of Musca domestica (Diptera, Muscidae) in Misan Province
Authors: Alsaad Rasha 
Published: May 2023

Background: Houseflies are the most common type of Diptera, specifically Muscidae, worldwide, representing more than 90% of all species. This family has over 170 genera and 4200 species, but a few are of medical significance. This study aimed to estimate and assessing the measures to control and prevent grow-up inside houses and flying of the housefly (Musca domestica Linnaeus, 1758) in Misan. Methods: The study occurred over 12 months, from December 2020 to December 2021. Using plastic containers, Musca flies were collected from all potential breeding sites in the study region (inside and around houses). Sticky oil paper and traps were used to collect the insects. The collected insects were transferred to sealed plastic containers and then to the laboratory of the Department of Microbiology. Results: Out of 200 randomly selected houses, 150 (75%) contained insects. Light traps and sticky oil papers were the most effective control measures, with 26.7% and 25.9% of the Musca collected from these methods, respectively. The ratio of male (233) to female (456) Musca was 1:2, with a significant difference between the frequencies (P<0.05). A large population of houseflies was collected during the hot season (501, 72.7%), whereas fewer Musca were collected during the cold months (188, 27.3%), with a strongly significant difference (P<0.05). The percentage of HI was 54.4%, the CI was 21.9%, and the BI was 79.9%. The overall larval densities (LD) were at a medium level. Conclusions: Misan has a high density of Musca houseflies, with females being more prominent than males. Hot climate, humid sites, and dirty places are responsible for the breeding of houseflies. The overall larval density was medium. Therefore, the risk of transmitting infectious diseases by houseflies is high within the boundaries of Misan province, and effective control parameters should include measures like light traps and sticky oil.
In-air Hand Gesture Signature Recognition: An iHGS Database Acquisition Protocol
Authors: Khoh Wee How , Pang Ying Han , Yap Hui Yen 
Published: May 2023

Background: With the advances in current technology, hand gesture recognition has gained considerable attention. It has been extended to recognize more distinctive movements, such as a signature, in human-computer interaction (HCI) which enables the computer to identify a person in a non-contact acquisition environment. This application is known as in-air hand gesture signature recognition. To our knowledge, there are no publicly accessible databases and no detailed descriptions of the acquisitional protocol in this domain. Methods: This paper aims to demonstrate the procedure for collecting the in-air hand gesture signature’s database. This database is disseminated as a reference database in the relevant field for evaluation purposes. The database is constructed from the signatures of 100 volunteer participants, who contributed their signatures in two different sessions. Each session provided 10 genuine samples enrolled using a Microsoft Kinect sensor camera to generate a genuine dataset. In addition, a forgery dataset was also collected by imitating the genuine samples. For evaluation, each sample was preprocessed with hand localization and predictive hand segmentation algorithms to extract the hand region. Then, several vector-based features were extracted. Results: In this work, classification performance analysis and system robustness analysis were carried out. In the classification analysis, a multiclass Support Vector Machine (SVM) was employed to classify the samples and 97.43% accuracy was achieved; while the system robustness analysis demonstrated low error rates of 2.41% and 5.07% in random forgery and skilled forgery attacks, respectively. Conclusions: These findings indicate that hand gesture signature is not only feasible for human classification, but its properties are also robust against forgery attacks.
The mutual benefits of comparing energy system models and integrated assessment models
Authors: Henke Hauke , Dekker Mark , Lombardi Francesco , Pietzcker Robert , Fragkos Panagiotis , Zakeri Behnam , Rodrigues Renato , Sitarz Joanna , Emmerling Johannes , Fattahi Amir , Dalla Longa Francesco , Tatarewicz Igor , Fotiou Theofano , Lewarski Michał , Huppmann Daniel , Kavvadias Kostas , van der Zwaan Bob , Usher Will 
Published: May 2023

Background: The transition to a carbon neutral society such as that envisaged in the European Union Green Deal requires careful and comprehensive planning. Integrated assessment models (IAMs) and energy system models (ESMs) are both commonly used for policy advice and in the process of policy design. In Europe, a vast landscape of these models has emerged and both kinds of models have been part of numerous model comparison and model linking exercises. However, IAMs and ESMs have rarely been compared or linked with one another. Methods: This study conducts an explorative comparison and identifies possible flows of information between 11 of the integrated assessment and energy system models in the European Climate and Energy Modelling Forum. The study identifies and compares regional aggregations and commonly reported variables We define harmonised regions and a subset of shared result variables that enable the comparison of results across the models. Results: The results highlight similarities and differences on final electricity demand, electricity supply and hydrogen across three levels of aggregation. However, the differences between the regional aggregation of the models limit detailed analysis. Conclusions: This first-of-its-kind comparison and analysis of modelling results across model type boundaries provides modellers and policymakers with a better understanding of how to interpret both IAM and ESM results. It also highlights the need for community standards for region definitions and information about reported variables to facilitate future comparisons of this kind.
Drivers of Resistance in Uganda and Malawi (DRUM): a protocol for the evaluation of One-Health drivers of Extended Spectrum Beta Lactamase (ESBL) resistance in Low-Middle Income Countries (LMICs)
Authors: Cocker Derek , Sammarro Melodie , Chidziwisano Kondwani , Elviss Nicola , Jacob Shevin T. , Kajumbula Henry , Mugisha Lawrence , Musoke David , Musicha Patrick , Roberts Adam P. , Rowlingson Barry , Singer Andrew C. , Byrne Rachel L. , Edwards Thomas , Lester Rebecca , Wilson Catherine N. , Hollihead Beth , Thomson Nicholas R. , Jewell Christopher P. , Morse Tracy , Feasey Nicholas A. 
Published: May 2023

In sub-Saharan Africa (sSA), there is high morbidity and mortality from severe bacterial infection and this is compounded by antimicrobial resistance, in particular, resistance to 3rd-generation cephalosporins. This resistance is typically mediated by extended-spectrum beta lactamases (ESBLs). To interrupt ESBL transmission it will be important to investigate how human behaviour, water, sanitation, and hygiene (WASH) practices, environmental contamination, and antibiotic usage in both urban and rural settings interact to contribute to transmission of ESBL E. coli and ESBL K. pneumoniae between humans, animals, and the environment. Here we present the protocol for the Drivers of Resistance in Uganda and Malawi (DRUM) Consortium, in which we will collect demographic, geospatial, clinical, animal husbandry and WASH data from a total of 400 households in Uganda and Malawi. Longitudinal human, animal and environmental sampling at each household will be used to isolate ESBL E. coli and ESBL K. pneumoniae. This will be complimented by a Risks, Attitudes, Norms, Abilities and Self-Regulation (RANAS) survey and structured observations to understand the contextual and psychosocial drivers of regional WASH practices. Bacterial isolates and plate sweeps will be further characterised using a mixture of short-,long-read and metagenomic whole-genome sequencing. These datasets will be integrated into agent-based models to describe the transmission of EBSL resistance in Uganda and Malawi and allow us to inform the design of interventions for interrupting transmission of ESBL-bacteria.
Structure of the transmembrane protein 2 (TMEM2) ectodomain and its apparent lack of hyaluronidase activity
Authors: Niu Muyuan , McGrath Molly , Sammon Douglas , Gardner Scott , Morgan Rhodri Marc , Di Maio Antonio , Liu Yan , Bubeck Doryen , Hohenester Erhard 
Published: May 2023

Background: Hyaluronic acid (HA) is a major polysaccharide component of the extracellular matrix. HA has essential functions in tissue architecture and the regulation of cell behaviour. HA turnover needs to be finely balanced. Increased HA degradation is associated with cancer, inflammation, and other pathological situations. Transmembrane protein 2 (TMEM2) is a cell surface protein that has been reported to degrade HA into ~5 kDa fragments and play an essential role in systemic HA turnover. Methods: We produced the soluble TMEM2 ectodomain (residues 106-1383; sTMEM2) in human embryonic kidney cells (HEK293) and determined its structure using X-ray crystallography. We tested sTMEM2 hyaluronidase activity using fluorescently labelled HA and size fractionation of reaction products. We tested HA binding in solution and using a glycan microarray. Results: Our crystal structure of sTMEM2 confirms a remarkably accurate prediction by AlphaFold. sTMEM2 contains a parallel β-helix typical of other polysaccharide-degrading enzymes, but an active site cannot be assigned with confidence. A lectin-like domain is inserted into the β-helix and predicted to be functional in carbohydrate binding. A second lectin-like domain at the C-terminus is unlikely to bind carbohydrates. We did not observe HA binding in two assay formats, suggesting a modest affinity at best. Unexpectedly, we were unable to observe any HA degradation by sTMEM2. Our negative results set an upper limit for kcat of approximately 10-5 min-1. Conclusions: Although sTMEM2 contains domain types consistent with its suggested role in TMEM2 degradation, its hyaluronidase activity was undetectable. HA degradation by TMEM2 may require additional proteins and/or localisation at the cell surface.
Recursive Importance Sketching for Rank Constrained Least Squares: Algorithms and High-Order Convergence
Authors: Luo Yuetian , Huang Wen , Li Xudong , Zhang Anru 
Published: May 2023

Solving Rank Constrained Least Squares via Recursive Importance Sketching In statistics and machine learning, we sometimes run into the rank-constrained least squares problems, for which we need to find the best low-rank fit between sets of data, such as trying to figure out what factors are affecting the data, filling in missing information, or finding connections between different sets of data. This paper introduces a new method for solving this problem called the recursive importance sketching algorithm (RISRO), in which the central idea is to break the problem down into smaller, easier parts using a unique technique called “recursive importance sketching.” This new method is not only easy to use, but it is also very efficient and gives accurate results. We prove that RISRO converges in a local quadratic-linear and quadratic rate under some mild conditions. Simulation studies also demonstrate the superior performance of RISRO.
PENGUKURAN KINERJA SUMBER DAYA MANUSIA MENGGUNAKAN METODE HUMAN RESOURCE SCORECARD
Authors: Karlina Aulia , Samanhudi Didi 
Published: May 2023

In recent research, employee performance evaluations have not been carried out comprehensively. However, problems related to employee performance are the increasing number of complaints and the achievement of project targets on time. This study aims to determine the level of employee performance and provide suggestions for improving key performance indicator (KPI) below the target. The sampling method is non-probability sampling with purposive sampling. The method used is the Human Resource Scorecard (HRS) supported by the Analytical Hierarchy Process (AHP) and Traffic Light System (TLS). The results showed that the performance measurement score of PT. Modern Pulsa Investama in 2021 is 2,23 (less) with a TLS of 2,90; in 2022, it is 2,99 (medium), with a TLS of 5,86, indicating satisfactory performance. Based on 15 KPIs in 2021, 4 were obtained in the green group, 5 in the yellow group, and 6 in the red group. Of the 15 KPIs in 2022, 6 were obtained in the green group, 6 in the yellow group, and 3 in the red group. KPIs that go on a yellow to red scale are the focus of improvement. PT. Modern Pulsa Investama is a company that develops bill payment applications and online product purchases.
Desvendando a estrutura informacional de [até x] em português, em uma perspectiva baseada no uso
Authors: Leite de Oliveira Diego 
Published: May 2023

Este artigo explora o potencial expressivo da construção [ATÉ X] em português, em uma perspectiva construcionista baseada no uso (GOLDBERG, 1995, 2006, 2019; CROFT 2001; DIESSEL, 2019). Para isso, vale-se de dois procedimentos metodológicos: a análise qualitativa de instâncias reais de uso da língua e a análise introspectiva. Como hipóteses centrais de análise figuram: 1) atécomo elemento léxico-gramatical pode evocar pressuposições interpretáveis à luz do co-texto e do contexto comunicativo; 2) o padrão construcional [ATÉ X] com semântica de inclusão tende a ser recrutado para o domínio focal da sentença dados os aspectos apresentados na hipótese 1. Resultados da análise indicam que, dada a semântica escalar de até e a apresentação do elemento que figura em X no limite de uma escala, o padrão construcional em pauta permite a evocar uma pressuposição de que o participante em X seria o menos provável a ocupar o slot X, gerando uma quebra de expectativa e, com isso permitindo a interpretação de X sob o escopo da asserção e, portanto, como elemento focal.
Outcomes of morbidly obese patients undergoing total hip arthroplasty with the anterior-based muscle-sparing approach
Authors: Shevenell Bailey E. , Mackenzie Johanna , Fisher Lillian , McGrory Brian , Babikian George , Rana Adam J. 
Published: May 2023

AimsObesity is associated with an increased risk of hip osteoarthritis, resulting in an increased number of total hip arthroplasties (THAs) performed annually. This study examines the peri- and postoperative outcomes of morbidly obese (MO) patients (BMI ≥ 40 kg/m2) compared to healthy weight (HW) patients (BMI 18.5 to < 25 kg/m2) who underwent a THA using the anterior-based muscle-sparing (ABMS) approach.MethodsThis retrospective cohort study observes peri- and postoperative outcomes of MO and HW patients who underwent a primary, unilateral THA with the ABMS approach. Data from surgeries performed by three surgeons at a single institution was collected from January 2013 to August 2020 and analyzed using Microsoft Excel and Stata 17.0.ResultsThis study compares 341 MO to 1,140 HW patients. Anaesthesia, surgery duration, and length of hospital stay was significantly lower in HW patients compared to MO. There was no difference in incidence of pulmonary embolism, periprosthetic fracture, or dislocation between the two groups. The rate of infection in MO patients (1.47%) was significantly higher than HW patients (0.14%). Preoperative patient-reported outcome measures (PROMs) show a significantly higher pain level in MO patients and a significantly lower score in functional abilities. Overall, six-week and one-year postoperative data show higher levels of pain, lower levels of functional improvement, and lower satisfaction scores in the MO group.ConclusionThe comorbidities of obesity are well studied; however, the implications of THA using the ABMS approach have not been studied. Our peri- and postoperative results demonstrate significant improvements in PROMs in MO patients undergoing THA. However, the incidence of deep infection was significantly higher in this group compared with HW patients.Cite this article: Bone Jt Open 2023;4(5):299–305.