bluuebunny/crossref_metadata_2025_split huggingface dataset:
C96. The First Percutaneous Transvenous Mitral Commissurotomy guided by Three Dimensional Transesophageal Echocardiography in Haji Adam Malik General Hospital Medan
Authors: Indra R K , Lubis A C , Ardini T W , Hasan H 
Published: March 2023

Abstract

Background
Percutaneous Transvenous Mitral Commissurotomy (PTMC) has become the treatment of choice for patients with mitral stenosis. PTMC guided by three-dimensional Transesophageal Echocardiography (3D-TEE) promise of greater safety and efficacy.

Case Summary
We report a 29-year-old woman who came to our outpatient clinic with shortness of breath as a chief complaint for the past three months. ECG depicted sinus rhythm. Transthoracic Echocardiography (TTE) and 3D-TEE showed severe mitral stenosis with MVA planimetry: 0.8 cm2, MV mean PG 12 mmHg, MV PHT 403 ms, Wilkins score was 4 and no thrombus was found. Therefore, we decided to do PTMC. We successfully done the antegrade transseptal puncture by fluoroscopy guided by two-dimensional (2D) TEE . Then, we used Inoue-balloon catheter No. 24 to dilate the mitral valve. Afterthat, we did 3D-TEE evaluation of the mitral valve area and it showed a significant improvement, with MVA 3D planimetry: 2.0 cm2 and MV mean PG: 4 mmHg and we found moderate mitral regurgitation (MR VC 0.4 cm, MR PISA: 0.3 cm), so we decided to end the procedure.

Discussion
In this case, the PTMC procedure was carried with 2D and 3D-TEE guiding, where process run more easily because interventionist can ensure the targeted site during transeptal puncture, navigation to the mitral valve and post inflation inspection. 3D-TEE guiding can also directly ensure the success of PTMC in real time by evaluating the MVA planimetry (pre and post PTMC) and the mitral regurgitation.
C100. Torsades de Pointes (Polymorphic VT) as a Manifestation in Hypothyroid Patient’s: A Case Report
Authors: Akina M T , Muzakkir A 
Published: March 2023

Abstract

Background
Hypothyroidism is a common endocrine disorder with varying abnormalities including cardiac manifestations consisting of structural, functional, and electrical conduction problems especially in severe cases. Torsades de pointes (TdP) is a very rare initial presentation in a patient with hypothyroidism. We report a patient with severe hypothyroidism manifest with life-threatening arrhythmias.

Case Description
A 48-year-old man who underwent emergency resuscitation suffering from cardiac arrest. On admission, the patient collapsed and was unresponsive. Electrocardiography (ECG) showed QT interval prolongation, and polymorphic ventricular tachycardia (TdP). Laboratory test revealed marked hypokalemia (potassium concentration of 2.6 mmol per liter) and unexpected severe hypothyroid (Free T4 (FT4) was &lt;0.07 [normal 0.93-1.71] μg/dl; thyroid-stimulating hormone (TSH) was &gt;60.0 [normal 0.27-4.20] mIU/mL). Temporary cardiac pacing was placed for managing specific arrhythmias. The patient was also treated with levothyroxine 100 μg per day, and the underlying electrolyte disturbance was corrected. Treatment with levothyroxine was continued in outpatient clinic. ECG and thyroid tests were returned to normal limit within six weeks.

Discussion
Clinicians need to highlight that TdP is relatively rare in hypothyroidism. Early diagnosis and prompt management were needed due to potential fatal cardiac manifestation if left untreated. All patients with overt hypothyroidism with TSH &gt;10 mIU/L should be treated. Administration of levothyroxine is a mandatory treatment and should be monitored carefully and safely to eliminate arrhythmias.
C102. Transjugular venous access for permanent pacemaker as an approach when there was no other choice : A Case Report
Authors: Fathoni E , Rizal A 
Published: March 2023

Abstract

Background
When conventional veins are inaccessible, the transjugular Seldinger technique for permanent pacemaker (PPM) implantation could be used as the last resort.

Case Description
An 80-years-old woman had wound skin extrusion and infection at the site of left deltopectoral pocket of permanent pacemaker. After removing the PPM lead generator and debriding the wound, a single chamber PPM was implanted in right hemithorax after temporary pacemaker backup. There was no access in the left area and proximal vein stenosis was found following an early attempt to reach the right subclavian vein and cut-down surgical procedure. Other stenosis were also found at the upper right veins by venography. A single chamber PPM was implanted utilizing the Seldinger technique to puncture the internal jugular vein without surgical cut-down and dissection for tunneling the lead from right jugular area to deltopectoral pocket. Lead test came out acceptable: R wave of 12 mV, Slew &gt;4 V/s current &gt;25 mA, impedance 688 Ω and threshold of 0.87V. There were no pneumothorax and other complications followed.

Discussion
Venous occlusion could be found in patients undergoing pacemaker insertion. For some cases, the internal jugular vein works as an alternative access for PPM insertion without surgical cut down. Percutaneous access to the internal jugular vein is safer, and the risk of lead fractures is reduced.
C103. Viral Myocarditis Mimicking Acute Myocardial Infarction: A Case Report
Authors: Seriulina R A , Martanto E 
Published: March 2023

Abstract

Background
Acute myocarditis still challenging diagnosis in cardiology. Its entity is rarely recognized and its pathophysiology defectively understood. Viral infection remains the most commonly identified cause for myocarditis, but bacteria, fungi, protozoa, and helminths have also been implicated.

Case Summary
A 61 years old female was admitted to emergency department, complaining typical angina since 12 hours prior to admission. She also complains nausea, vomit, flu like syndrome, and low grade fever since 1 weeks prior to admission. She was a former smoker and had hypertension. ECG in 6 hours on admission ECG revealed sinus rhythm, ST-elevation anteroseptal, ischemic lateral-high lateral and there is no evolution compare to previous ECG which taken in other hospital. Laboratory findings showed increased of troponin enzyme. Coronary angiography was performed with result normal coroner. Echocardiography revealed normal all chambers, concentric LV remodelling, normal LV systolic function with ejection fraction 51% without regional wall motion abnormalities. On the next day, troponin levels decrease and the ECG remain abnormal without any changes. In order to get more data, CMR was planned, but she refused. Patients was discharged uneventful.

Discussion
Myocarditis is challenging diagnosis due to the heterogenicity clinical presentation. It presents in many different ways, ranging from mild “flu-like” symptoms, mild symptoms of chest pain and palpitations associated with transient ECG changes. Chest pain in acute myocarditis may mimic typical angina and be associated with electrocardiographic changes, including ST-segment elevation and often misdiagnosed as ACS until coronary angiography demonstrates normal or non-obstructive coronary arteries.
Time period effects in work disability due to common mental disorders among young employees in Sweden—a register-based cohort study across occupational classes and employment sectors
Authors: Amin Ridwanul , Mittendorfer-Rutz Ellenor , Björkenstam Emma , Virtanen Marianna , Helgesson Magnus , Gustafsson Niklas , Rahman Syed 
Published: March 2023

AbstractBackgroundWe aimed to investigate time period effects in the risk of work disability, defined as long-term sickness absence (LTSA) and disability pension (DP) due to common mental disorders (CMDs), among young employees according to employment sector (private/public) and occupational class (non-manual/manual).MethodsThree cohorts, including all employed individuals with complete information on employment sector and occupational class, aged 19–29 years and resident in Sweden on 31 December 2004, 2009 and 2014 (n = 573 516, 665 138 and 600 889, respectively) were followed for 4 years. Multivariate-adjusted hazard ratios (aHRs) with 95% confidence intervals (CIs) were estimated to examine the risk of LTSA and DP due to CMDs using Cox regression analyses.ResultsIn all cohorts, public sector employees had higher aHRs for LTSA due to CMDs than private sector employees, irrespective of occupational class, e.g. aHR, 95% CI: 1.24, 1.16–1.33 and 1.15, 1.08–1.23 among non-manual and manual workers in cohort 2004. The rates of DP due to CMDs were much lower in cohorts 2009 and 2014 than 2004 leading to uncertain risk estimates in the later cohorts. Still, public sector manual workers had a higher risk for DP due to CMDs than manual workers in the private sector in cohort 2014 than in 2004 (aHR, 95% CI: 1.54, 1.34–1.76 and 3.64, 2.14–6.18, respectively).ConclusionsManual workers in the public sector seem to have a higher risk of work disability due to CMDs than their counterparts in the private sector calling for the need for early intervention strategies to prevent long-term work disability.
Sex-specific transcription and DNA methylation landscapes of the Asian citrus psyllid, a vector of huanglongbing pathogens
Authors: Yu Xiudao , Marshall Hollie , Liu Yan , Xiong Yu , Zeng Xiangdong , Yu Haizhong , Chen Wei , Zhou Guchun , Zhu Bo , Ross Laura , Lu Zhanjun 
Published: March 2023

AbstractThe relationship of DNA methylation and sex-biased gene expression is of high interest, it allows research into mechanisms of sexual dimorphism and the development of potential novel strategies for insect pest control. The Asian citrus psyllid, Diaphorina citri Kuwayama, is a major vector for the causative agents of Huanglongbing (HLB), which presents an unparalleled challenge to citrus production worldwide. Here, we identify the X chromosome of D. citri and investigate differences in the transcription and DNA methylation landscapes between adult virgin males and females. We find a large number of male-biased genes on the autosomes and a depletion of such on the X chromosome. We have also characterized the methylome of D. citri, finding low genome-wide levels, which is unusual for an hemipteran species, as well as evidence for both promoter and TE methylation. Overall, DNA methylation profiles are similar between the sexes but with a small number of differentially methylated genes found to be involved in sex differentiation. There also appears to be no direct relationship between differential DNA methylation and differential gene expression. Our findings lay the groundwork for the development of novel epigenetic-based pest control methods, and given the similarity of the D. citri methylome to some other insect species, these methods could be applicable across agricultural insect pests.
Romboutsia lituseburensisJCM1404 supplementation ameliorated endothelial function via gut microbiota modulation and lipid metabolisms alterations in obese rats
Authors: Yin Honggang , Huang Junhao , Guo Xiaozheng , Xia Jingbo , Hu Min 
Published: March 2023

AbstractOur previous study revealed moderate-intensity exercise improved endothelial function associated with decreasing Romboutsia in rats on a high-fat diet. However, whether Romboutsia influences endothelial function remains unclear. The aim of this study was to determine the effects of Romboutsia lituseburensis JCM1404 on the vascular endothelium of rats under standard diet (SD) or high-fat diet (HFD). Romboutsia lituseburensis JCM1404 had a better improvement effect on endothelial function under HFD groups, while no significant effect on small-intestinal and blood vessel morphology. HFD significantly decreased villus height of small intestine and increased outer diameter and media thickness of the vascular tissue. After the treatments by R. lituseburensis JCM1404, the expression of claudin5 was increased in the HFD groups. Romboutsia lituseburensis JCM1404 was found to increase alpha diversity in the SD groups, with an increase in beta diversity in the HFD groups. The relative abundance of Romboutsia and Clostridium_sensu_stricto_1 was decreased significantly in both diet groups after R. lituseburensis JCM1404 intervention. The functions of human diseases and endocrine and metabolic diseases significantly downregulated in the HFD groups by Tax4Fun analysis. Furthermore, we found Romboutsia was significantly associated with bile acids, triglycerides, amino acids and derivatives and organic acids and derivatives in the SD groups, while Romboutsia was significantly associated with triglycerides and free fatty acid in the HFD groups. Romboutsia lituseburensis JCM1404 significantly upregulated several metabolism-related pathways by KEGG analysis in the HFD groups, including glycerolipid metabolism, cholesterol metabolism, regulation of lipolysis in adipocytes, insulin resistance, fat digestion and absorption, thermogenesis. Overall, R. lituseburensis JCM1404 supplementation ameliorated endothelial function via gut microbiota modulation and lipid metabolisms alterations in obese rats.
Dynamic single cell analysis in a proximal-tubule-on-chip reveals heterogeneous epithelial colonization strategies of uropathogenic Escherichia coli under shear stress
Authors: Antypas Haris , Zhang Tianqi , Choong Ferdinand X , Melican Keira , Richter-Dahlfors Agneta 
Published: March 2023

Abstract
The urinary tract is a hydrodynamically challenging microenvironment and uropathogenic Escherichia coli (UPEC) must overcome several physiological challenges in order to adhere and establish a urinary tract infection. Our previous work in vivo revealed a synergy between different UPEC adhesion organelles, which facilitated effective colonization of the renal proximal tubule. To allow high-resolution real-time analysis of this colonization behavior, we established a biomimetic proximal-tubule-on-chip (PToC). The PToC allowed for single-cell resolution analysis of the first stages of bacterial interaction with host epithelial cells, under physiological flow. Time-lapse microscopy and single-cell trajectory analysis in the PToC revealed that while the majority of UPEC moved directly through the system, a minority population initiated heterogeneous adhesion, identified as either rolling or bound. Adhesion was predominantly transient and mediated by P pili at the earliest time-points. These bound bacteria initiated a founder population which rapidly divided, leading to 3D microcolonies. Within the first hours, the microcolonies did not express extracellular curli matrix, but rather were dependent on Type 1 fimbriae as the key element in the microcolony structure. Collectively, our results show the application of Organ-on-chip technology to address bacterial adhesion behaviors, demonstrating a well-orchestrated interplay and redundancy between adhesion organelles that enables UPEC to form microcolonies and persist under physiological shear stress.
Assessing Flexibility of Solution Strategy: Strategy Shifting as a Measure of Cognitive Reserve
Authors: Barulli Daniel , Habeck Christian , Stern Yaakov 
Published: March 2023

Abstract

Objectives
This series of experiments explores whether flexibility in strategy shifting might function as an expression of cognitive reserve (CR).

Methods
A reasoning task was designed using matrix reasoning stimuli that each required 1 of 2 specific solution strategies: logicoanalytic and visuospatial. It was formatted as a task-switching paradigm, assessing the ability to switch between solution strategies as measured by switch costs. Study 1 was done on Amazon Mechanical Turk and included an assessment of CR proxies. Study 2 used participants who had been studied extensively with neuropsychological assessments and structural neuroimaging.

Results
Study 1 found that switch costs increased with aging. In addition, a relationship between switch costs and CR proxies was noted, suggesting a relationship between the flexibility of strategy shifting and CR. The results of Study 2 again indicated that age negatively affected strategy-shifting flexibility, but that individuals with higher CR as measured with standard proxies performed better. The flexibility measure accounted for additional variance in cognitive performance over that explained by cortical thickness, suggesting that it may contribute to CR.

Discussion
Overall, the results are consistent with the idea that flexibility in strategy shifting might be 1 cognitive process that underlies cognitive reserve.
High-throughput imaging of powdery mildew resistance of the winter wheat collection hosted at the German Federal ex situ Genebank for Agricultural and Horticultural Crops
Authors: Hinterberger Valentin , Douchkov Dimitar , Lueck Stefanie , Reif Jochen C , Schulthess Albert W 
Published: March 2023

AbstractBackgroundGenebanks worldwide are transforming into biodigital resource centers, providing access not only to the plant material itself but also to its phenotypic and genotypic information. Adding information for relevant traits will help boost plant genetic resources' usage in breeding and research. Resistance traits are vital for adapting our agricultural systems to future challenges.FindingsHere we provide phenotypic data for the resistance against Blumeria graminis f. sp. tritici, the causal agent of wheat powdery mildew—a substantial risk to our agricultural production. Using a modern high-throughput phenotyping system, we infected and photographed a total of 113,638 wheat leaves of 7,320 winter wheat (Triticum aestivum L.) plant genetic resources of the German Federal ex situ Genebank for Agricultural and Horticultural Crops and 154 commercial genotypes. We quantified the resistance reaction captured by images and provide them here, along with the raw images.ConclusionThis massive amount of phenotypic data, combined with already published genotypic data, also provides a valuable and unique training dataset for the development of novel genotype-based predictions as well as mapping methods.
Material encounters: the alternative use of clay tobacco pipes in England and Wales, c.1600–1900
Authors: Inskip Sarah , Joy Muir Angela 
Published: March 2023

Abstract
This article explores the ways in which clay tobacco pipes were used on or against the body for purposes other than smoking. Whereas most approaches to material culture in the past consider the intended uses of objects, this research focuses on alternative uses and the broader contexts in which these adaptations were made. Examination of pipes used as weapons and medical instruments provides new evidence of the physical worlds of those who encountered these objects. It also demonstrates how reading objects ‘against the grain’ through analysis of alternative uses of everyday objects expands what we can learn from material culture.
Race and COVID-19 among Social Workers in Health Settings: Physical, Mental Health, Personal Protective Equipment, and Financial Stressors
Authors: Zerden Lisa de Saxe , Ross Abigail M , Cederbaum Julie , Guan Ting , Zelnick Jennifer , Ruth Betty J 
Published: March 2023

AbstractSocial work is an essential workforce integral to the United States’ public health infrastructure and response to COVID-19. To understand stressors among frontline social workers during COVID-19, a cross-sectional study of U.S-based social workers (N = 1,407) in health settings was collected (in June through August 2020). Differences in outcome domains (health, mental health, personal protective equipment [PPE] access, financial stress) were examined by workers’ demographics and setting. Ordinal logistic, multinomial, and linear regressions were conducted. Participants reported moderate or severe physical (57.3 percent) and mental (58.3 percent) health concerns; 39.3 percent expressed PPE access concerns. Social workers of color were more likely to report significantly higher levels of concern across all domains. Those identifying as Black, American Indian/Alaska Native (AIAN), Asian American/Pacific Islander (AAPI), multiracial, or Hispanic/Latinx were over 50 percent more likely to experience either moderate or severe physical health concerns, 60 percent more likely to report severe mental health concerns, and over 30 percent more likely to report moderate PPE access concerns. The linear regression model was significantly associated with higher levels of financial stress for social workers of color. COVID-19 has exposed racial and social injustices that that hold true for social workers in health settings. Improved social systems are critical not just for those impacted by COVID-19, but also for the protection and sustainability of the current and future workforce responding to COVID-19.
Shedding New Light on High-Risk Phenotypes for Pouchitis
Authors: Barnes Edward L , Chang Shannon 
Published: March 2023

Lay Summary
Identifying those patients at the greatest risk for pouchitis at the time of ileal pouch-anal anastomosis for ulcerative colitis remains a challenge. We discuss the importance of this topic by reviewing recent data regarding the impact of acute severe ulcerative colitis on risk of pouchitis and the implications for future clinical decisions and studies of risk stratification.
Examining pharmacists’ anti-doping knowledge and skills in assisting athletes to avoid unintentional use of prohibited substances
Authors: Greenbaum Deborah H , McLachlan Andrew J , Roubin Rebecca H , Moles Rebekah , Chaar Betty B 
Published: March 2023

Abstract

Objectives
To explore the knowledge and skills of pharmacists practicing in Sydney, Australia, in preventing the use of prohibited medications by athletes.

Methods
Using a simulated-patient study design, the researcher (an athlete and pharmacy student herself) contacted 100 Sydney pharmacies by telephone requesting advice about taking a salbutamol inhaler (a WADA-prohibited substance with conditional requirements), for exercise-induced asthma, following a set interview protocol. Data were assessed for both clinical and anti-doping advice appropriateness.

Key findings
Appropriate clinical advice was provided by 66% of pharmacists in the study, appropriate anti-doping advice was provided by 68%, and 52% provided appropriate advice across both aspects. Of the respondents, only 11% provided both clinical and anti-doping advice at a comprehensive level. Identification of accurate resources was made by 47% of pharmacists.

Conclusions
Whilst most participating pharmacists had the skills to deliver assistance regarding the use of prohibited substances in sports, many lacked core knowledge and resources to enable them to deliver comprehensive care to prevent harm and protect athlete-patients from anti-doping violations. A gap was identified regarding advising/counselling athletes, indicating the need for additional education in sport-related pharmacy. This education would need to be coupled with the incorporation of sport-related pharmacy into current practice guidelines to enable pharmacists to uphold their duty of care and for athletes to benefit from their medicines-related advice.
Dignity Deployed: An Examination of Refugee Rights through Domestic Dignity Jurisprudence
Authors: Garfinkel Rebecca J 
Published: March 2023

Abstract
The 1951 Convention relating to the Status of Refugees (Refugee Convention) provides protection for people with a well-founded fear of persecution who find themselves outside their country of nationality. The treaty not only sets out a legal status for those recognized as refugees by the country of asylum, but also certain civil, political, social, and economic rights throughout the refugee status determination process. Yet, despite being faced with the highest numbers of displaced people since the Second World War, States parties to the Refugee Convention routinely fail to meet the standards set out by the Convention. This article explores how domestic courts enforce treaty compliance not as a matter of international law, but rather by using the concept of constitutional dignity. The discussion examines how constitutional courts around the world have used dignity as both a substantive right and a functional standard in order to fulfil the promises of the Refugee Convention. The article concludes with an argument for dignity as a powerful tool to fill gaps in refugee protection globally.