bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Green Lean Body Capsules on Body Weight, Lipid Profile, and Renal Physiology and Histology in Albino Rats
Authors: Al-Lami Makarim Q. 
Published: April 2023

Background: Many anti-obesity medicines have been increased in recent years to solve the problem of obesity; among these medicines are Green Lean Body Capsules (GLBCs) which contain green plants and fruits extract.Objective: This study was designed to evaluate the effects of daily oral consumption of GLBCs on level of serum lipids, renal function tests, and the histological structure of the kidney in albino rats.Materials and Methods: Twenty adult albino male rats weighing 240-260 g were divided into 2 equal groups: control group and GLBCs-treated group. During the 4-weeks treatment, each rat in the GLBCs-treated group was orally administered with 20 mg/kg B.W. of GLBCs, while the control rats were orally administered with 0.1 ml D.W. Body weights were monitored at the beginning and at the end of the experimental period. Lipid profile [total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), very lowdensity lipoprotein cholesterol (VLDL-C) and low-density lipoprotein cholesterol (LDL-C)], renal function tests (blood urea and serum creatinine) ; in addition to the histological examination of the kidney wereevaluated in all the rats.Results: The results revealed that body weight gain was significantly (P<0.05) less in the GLBCs-treated rats than in the control rats. Results of the lipid profile showed that the levels of TC, TG, LDL-C and VLDL-C were significantly (P<0.05) lower while the level of HDL-C was significantly (P < 0.05) higher in the GLBCs-treated rats than that in the control rats. Regarding the renal function tests, the results revealed that blood urea and serum creatinine levels in the GLBCs-treated rats were significantly (P<0.05) lower than that in the control rats. However, microscopic examination of the kidney revealed that both the control and the GLBCs-treated groups presented similar type of histological manifestations.Conclusion: The data presented in this study suggested that the compounds found in GLBCs may act synergistically to suppress body weight gain, decrease the level of serum lipids, and decrease the level of renal function tests without any histological abnormalities effect in the kidney.
Challenges in diagnosing fever in traveler returning from tropical ares – is it dengue or chikungunya? Case report
Authors: Bętkowska A , Hanke J , Krankowska D , Mikuła T , Wiercińska-Drapało A 
Published: April 2023

<p><strong>ABSTRACT</strong><br />Arthropod-borne viral infections caused by dengue virus (DENV) and chikungunya virus (CHIKV) are prevalent in the same regions and are spread by the same mosquito type (Aedes) and have similar clinical manifestations. <br />This study emphasized the challenges of diagnosing fever in a patient returning from a tropical area. We report a case of a 52-year-old patient who presented with fever, myalgia, and headache after travelling to Laos and Thailand. After ten days of the disease, the diagnosis of chikungunya was made. Recent travel history should be a standard part of assessment when consulting febrile patients and is essential for further diagnosis. Malaria should permanently be excluded from travellers returning from tropical regions with fever. In the differential diagnosis, dengue, chikungunya, and other mosquito-borne infections should be considered. Patients wishing to travel to such areas need to be educated beforehand on the necessary preventative measures.</p>
<p><strong>STRESZCZENIE</strong><br />Zakażenia wirusowe przenoszone przez stawonogi, wywoływane przez wirus dengi (DENV) i wirus chikungunya (CHIKV), występują w tych samych regionach i są rozprzestrzeniane przez ten sam rodzaj komarów (Aedes), a ich objawy kliniczne są podobne.<br />W pracy zwrócono uwagę na wyzwania związane z rozpoznaniem przyczyny gorączki u pacjentów powracających z obszarów tropikalnych. Przedstawiamy przypadek 52-letniego pacjenta, u którego wystąpiła gorączka, bóle mięśni i głowy po podróży do Laosu i Tajlandii. Po dziesięciu dniach trwania choroby postawiono rozpoznanie chikungunya. Wywiad dotyczący historii podróży powinien być standardowym elementem oceny podczas konsultacji pacjentów z gorączką i jest niezbędny do dalszej diagnostyki. U podróżnych powracających z regionów tropikalnych z gorączką należy w pierwszej kolejności wykluczać malarię. W diagnostyce różnicowej należy brać pod uwagę dengę, chikungunyę i inne choroby przenoszone przez komary. Pacjenci, którzy zamierzają podróżować do takich regionów, powinni wcześniej się przygotować w zakresie profilaktyki chorób<br />tropikalnych.</p>
The Image of Women’s Upper Commercial Schools in Hungarian Pedagogy in the First
Half of the 20th Century
Authors: Stummer Krisztina 
Published: April 2023

Abstract

The purpose of this study is to examine what image the journal Hungarian Pedagogy
conveyed about women's upper commercial schools in Hungary. The articles were reviewed
for the period between 1909 and 1938. In connection with the writings, we are looking
for answers to the following questions: Does the journal address women’s upper
commercial schools? What is the gender distribution of the authors? What views does the
author convey about the school? How do the publications fit into the portrayal of women
of the era? In total, we found four relevant articles by two authors. Both represent a
conservative point of view and speak rather negatively about the type of school.
Integrated Farming System Budidaya Ayam dan Ikan Nila dalam Pemberdayaan Masyarakat Desa
Authors: Widodo Ristito , Salsabila Yashinta , Jannah Nuria Fa'ul , Susanto Dani , Novianti Novianti , Agustin Via Anggi , Nurwahid Nurwahid , Pratiwi Freselia Ria , Yulia Utin , Sylviandari Irsa , Tribudi Yuli Arif 
Published: April 2023

Sistem Pertanian Terpadu (SPT) dalam pengabdian ini ditujukan untuk mengatasi permasalahan pemenuhan pakan ternak ayam dan ikan akibat harga pakan yang semakin tinggi tiap tahunnya, sekaligus pengurangan limbah organik hasil pertanian dan rumah tangga melalui pemanfaatan larva (maggot) Black Soldier Fly. Pengabdian dilakukan secara bertahap dari perencanaan, persiapan, sosialisasi, pelaksanaan dan pemantauan, hingga penyusunan laporan. Pengabdian telah terlaksana secara efektif, di mana limbah organik telah berkurang karena dimanfaatkan sebagai pakan dalam budidaya maggot. Maggot yang telah dibudidayakan kemudian juga berguna dalam pemberian pakan hewan ternak ayam dan ikan dengan harga yang terjangkau namun memiliki gizi yang tinggi bagi peningkatan imun dan pertumbuhan hewan ternak. Karenanya, SPT dalam pengabdian ini diasumsikan terlaksana secara efektif dalam pengurangan limbah organik sekaligus membantu peternak dalam penyediaan kebutuhan pakan hewan ternak ayam dan ikan.
Implementasi IOTs Pada Budidaya Udang Skala Rakyat Pokdakan GEMPA 01 Desa Kurau Kabupaten Bangka Tengah
Authors: Pratiwi Fika Dewi , Notonegoro Hartoyo , Zulkia Dwi Rizka 
Published: April 2023

Pokdakan Gempa 01 merupakan kelompok pembudidaya udang Vanname (tambak skala rakyat) di desa Kurau Barat, Kecamatan Koba, Kabupaten Bangka Tengah merintis usahanya mulai tahun 2020. Monitoring kualitas air masih dilakukan secara manual dan belum menerapkan teknologi. Padahal, tambak rakyat tersebut berpotensi untuk dapat scale-up ke skala yang lebih besar, apabila mampu mengaplikasikan teknologi, salah satunya berbasis Internet of Things (IoT). Oleh karena itu, program pemberdayaan masyarakat sangat diperlukan, yang ditujukan implementasi Internet of Things (IoT) untuk usaha budidaya tambak udang skala rakyat. Program pemberdayaan masyarakat dengan skema PMTU akan dilakukan, dengan pendekatan kombinasi metode yaitu melalui penyuluhan atau sosialisasi, pendampingan disertai partisipasi aktif mitra. Program yang direncanakan yaitu sosialisasi dan pengenalan sistem IoT (Internet of Things) dalam manajemen kualitas air budidaya, disertai pendampingan aplikasi sistem IoT. Tahap akhir adalah evaluasi dengan cara membagikan kuesioner skala Likert (1-4) kepada 10 anggota pokdakan Gempa 01. Berdasarkan hasil evaluasi diperoleh bahwa penggunaan IoTs yang tergolong baru tersebut sesuai dengan kebutuhan mitra, serta memiliki nilai manfaat untuk jangka panjang. Anggota kelompok mendapatkan wawasan baru, pemahaman meningkat setelah sosialisasi dan mereka menginginkan keberlanjutan kegiatan pengabdian guna mengingkatkan produktifitas tambak udang. Aplikasi IoT oleh mitra dapat men scale-up tambak udang skala rakyat, dengan indikator data kualitas air tersedia dalam data base yang dapat diakses kapanpun sehingga dapat menunjang keberhasilan budidaya dan dapat dijadikan early warning system sehingga kegagalan panen dapat dihindari.
Analysis on the thermal decomposition kinetics and storage period of biomass-based lycorine galanthamine
Authors: Qin Chong , Ling Weihong , Tian Chunlian 
Published: April 2023

As global ageing deepens and galanthamine is the preferred clinical drug for the treatment of mild to moderate Alzheimer’s disease, it will be valuable to examine the behaviour and mechanism of galanthamine’s thermal decomposition for its quality control, formulation process, evaluation of thermal stability, and expiry date in production. In order to study the pyrolysis of galanthamine hydrobromide with nitrogen as the carrier gas, a thermogravimetric-differential thermogravimetric technique (TG-DTG) was applied at a temperature rise rate of 10 K min−1 and a volume flow rate of 35 mL min−1. The apparent activation energy Ea and the prefactor A (Ea = 224.45 kJ mol−1 and lnA = 47.40) of the thermal decomposition reaction of galanthamine hydrobromide were calculated according to the multiple heating rate method (Kissinger and Ozawa) and the single heating rate method (Coats-Redfern and Achar), and the most probable mechanism function was derived, and then the storage period was inferred from Ea and E. A three-dimensional diffusion mechanism was suggested to control the thermal decomposition of galanthamine hydrobromide in accordance with the Jander equation, random nucleation and subsequent growth control, corresponding to the Mample one-way rule and the Avrami-Erofeev equation. As a result, the thermal decomposition temperature of galanthamine hydrobromide gradually increased with the rate of temperature rise. From Gaussian simulations and thermogravimetric data, galanthamine hydrobromide decomposed at the first stage (518.25–560.75 K) to release H2O, at the second stage (563.25–650.75 K) to generate CO, CO2, NH3 and other gases, and finally at the third stage (653.25–843.25 K) to release CO2. After 843.25 K, the residual molecular skeleton is cleaved to release CO2 and H2O. According to the Ea and A presenting in the first stage of thermal decomposition, it is assumed that the storage life of galanthamine hydrobromide at room temperature 298.15 K is 4–5 years.
First report on severe septic shock associated with human Parvovirus B19 infection after cardiac surgery
Authors: Xiang Chunlin , Wu Xiaoxiao , Wei Youkang , Li Tianlong , Tang Xuemei , Wang Yi , Zhang Xiaoqin , Huang Xiaobo , Wang Yiping 
Published: April 2023

BackgroundHuman Parvovirus B19 (PB19) is a single-stranded DNA virus. Septic shock from viremia is rare with PB19; however, this infection can progress to life-threatening conditions. We report the first case of severe septic shock associated with a PB19 infection after cardiac surgery.Case PresentationA 50-year-old Chinese woman received elective double metal valve replacement, including the aortic valve and the mitral valve, under cardiopulmonary bypass (CPB) and suffered severe septic shock on postoperative day (PD) 30. Through the detection of PB19-specific nucleic acids in blister fluid and serum samples via metagenomic next-generation sequencing (mNGS), positive serum PB19 IgM and no other proven infection, acute PB19 infection was confirmed. After five days of combined treatment, no further fever or abdominal discomfort was noted, and the patient’s circulation gradually became stable without vasoactive medications.ConclusionPB19 may be an unrecognized cause of septic shock, rash, fever of unknown origin or multiple systemic signs and symptoms, especially in immunosuppressed and immunocompetent critically ill patients. Investigations for viral aetiology are needed.
Association polymorphism of guanine nucleotide–binding protein β3 subunit (GNB3) C825T and insertion/deletion of the angiotensin-converting enzyme (ACE) gene with peripartum cardiomyopathy
Authors: Dewi Ivana Purnama , Wardhani Louisa Fadjri Kusuma , Maghfirah Irma , Dewi Kristin Purnama , Subagjo Agus , Alsagaff Mochamad Yusuf , Nugroho Johanes 
Published: April 2023

IntroductionPeripartum cardiomyopathy (PPCM) is a potentially life-threatening pregnancy-related heart disease. Genetic roles such as gene polymorphisms may relate to the etiology of PPCM. This study analyzes the association between single nucleotide gene polymorphism (SNP) guanine nucleotide–binding protein beta-3 subunit (GNB3) C825T and insertion/deletion (I/D) of the angiotensin-converting enzyme (ACE) gene with the incidence of PPCM.MethodsAn analytic observational study with a case–control design was conducted at the Integrated Cardiac Service Center of Dr. Soetomo General Hospital, Surabaya, Indonesia. PPCM patients of the case and control groups were enrolled. Baseline characteristic data were collected and blood samples were analyzed for SNP in the GNB3 C825T gene and for I/D in the ACE gene by using the polymerase chain reaction, restriction fragment length polymorphism, and Sanger sequencing. We also assessed ACE levels among different ACE genotypes using a sandwich-ELISA test.ResultsA total of 100 patients were included in this study, with 34 PPCM cases and 66 controls. There were significant differences in GNB3 TT and TC genotypes in the case group compared with that in the control group (TT: 35.3% vs. 10.6%, p = 0.003; TC: 41.2% vs. 62.5%, p = 0.022). The TT genotype increased the risk of PPCM by 4.6-fold. There was also a significant difference in the ACE DD genotype in the case group compared with that in the control group (26.5% vs. 9.1%, p = 0.021). DD genotypes increased the risk of PPCM by 3.6-fold. ACE levels were significantly higher in the DD genotype group than in the ID and II genotype groups (4,356.88 ± 232.44 pg/mL vs. 3,980.91 ± 77.79 pg/mL vs. 3,679.94 ± 325.77 pg/mL, p &lt; 0.001).ConclusionThe TT genotype of GNB3 and the DD genotype of the ACE are likely to increase the risk of PPCM. Therefore, these polymorphisms may be predisposing risk factors for PPCM incidence. ACE levels were significantly higher in the DD genotype group, which certainly had clinical implications for the management of PPCM patients in the administration of ACE inhibitors as one of the therapy options.
Mini-puberty testosterone and infant autistic traits
Authors: Tsompanidis Alex , Hampton Sarah , Aydin Ezra , Allison Carrie , Holt Rosemary , Baron-Cohen Simon 
Published: April 2023

BackgroundLevels of steroid hormones in the first three months of life, a period referred to as ‘mini-puberty’, are one of the earliest physiological differences between typical males and females postnatally. Autistic traits also show consistent typical sex differences in later infancy, after the 18th month of life. Previous studies have shown prenatal testosterone is associated with later levels of autistic traits. Studies testing if postnatal testosterone levels are associated with autistic traits have reported null results. No studies to date have investigated mini-puberty longitudinally or tested for interactions with baseline sex differences or familial likelihood of autism.MethodsThe ‘Cambridge Human Imaging and Longitudinal Development Study’ (CHILD) is a prospective enriched cohort study in Cambridge, UK. It includes physiological measurements in early infancy, as well as neurodevelopmental follow-ups over the first two years of life. A subset of the cohort also includes children with a family history of autism (a diagnosed parent or sibling). Salivary testosterone levels were assessed at two time-points, just after the 2nd and 6th month of life. Autistic traits were measured using the Quantitative Checklist of Autism in Toddlers (Q-CHAT) when the children were 18 months of age.ResultsSalivary testosterone levels were significantly higher during ‘mini-puberty’ in the 2nd and 3rd month of life, compared to after the 6th month of life, in both males and females. There was no significant sex difference at either time-point. Log-transformed testosterone levels were not associated with autistic traits (Q-CHAT). There was no interaction effect with infant sex, autism family history or baseline testosterone levels after mini-puberty (at &gt;6 months of age).ConclusionBoth male and female infants have elevated levels of salivary testosterone during mini-puberty but in this relatively small sample this was not associated with their later autistic traits at 18 months or their family history of autism. This suggests that prenatal rather than postnatal testosterone levels are more relevant for understanding the causes of autism. Future studies should test these relationships in larger samples.
Joint association of hyperuricemia and chronic kidney disease with mortality in patients with chronic heart failure
Authors: Wang Chi , Che Hebin , Zhou You , Wang Ruiqing , Zhu Di , Cheng Liting , Rao Chongyou , Zhong Qin , Li Zongren , Duan Yongjie , Xu Jiayu , Dong Wei , Bai Yongyi , He Kunlun 
Published: April 2023

BackgroundThe joint association of hyperuricemia and chronic kidney disease (CKD) with mortality in patients with chronic heart failure (CHF) is not conclusive.MethodsThis retrospective cohort study was conducted in Chinese People's Liberation Army General Hospital, Beijing, China. We included 9,367 patients with CHF, who were hospitalized between January 2011 and June 2019. The definitions of hyperuricemia and CKD were based on laboratory test, medication use, and medical record. We categorized patients with CHF into 4 groups according to the absence (-) or presence (+) of hyperuricemia and CKD. The primary outcomes included in-hospital mortality and long-term mortality. We used multivariate logistic regression and Cox proportional hazards regression to estimate the mortality risk according to the hyperuricemia/CKD groups.ResultsWe identified 275 cases of in-hospital mortality and 2,883 cases of long-term mortality in a mean follow-up of 4.81 years. After adjusting for potential confounders, we found that compared with the hyperuricemia-/CKD- group, the risks of in-hospital mortality were higher in the hyperuricemia+/CKD- group (odds ratio [OR], 95% confidence interval [CI]: 1.58 [1.01-2.46]), hyperuricemia-/CKD+ group (OR, 95% CI: 1.67 [1.10-2.55]), and hyperuricemia+/CKD+ group (OR, 95% CI: 2.12 [1.46-3.08]). Similar results were also found in long-term mortality analysis. Compared with the hyperuricemia-/CKD- group, the adjusted hazard ratios and 95% CI for long-term mortality were 1.25 (1.11-1.41) for hyperuricemia+/CKD- group, 1.37 (1.22-1.53) for hyperuricemia-/CKD+ group, and 1.59 (1.43-1.76) for hyperuricemia+/CKD+ group. The results remained robust in the sensitivity analysis.ConclusionsHyperuricemia and CKD, both individually and cumulatively, are associated with increased mortality risk in patients with CHF. These results highlighted the importance of the combined control of hyperuricemia and CKD in the management of heart failure.
Identifying the genetic causes of phenotypically diagnosed Pakistani mucopolysaccharidoses patients by whole genome sequencing
Authors: Gul Rutaba , Firasat Sabika , Schubert Mikkel , Ullah Asmat , Peña Elionora , Thuesen Anne C. B. , Hussain Mulazim , Staeger Frederik F. , Gjesing Anette P. , Albrechtsen Anders , Hansen Torben 
Published: April 2023

Background: Lysosomal storage disorders (LSDs) are a group of inherited metabolic diseases, which encompass more than 50 different subtypes of pathologies. These disorders are caused by defects in lysosomal enzymes, transporters, and other non-lysosomal proteins. Mucopolysaccharidosis (MPS) is the most common subgroup of lysosomal storage disorders in which the body is unable to properly breakdown mucopolysaccharides. The aim of the present study was to identify novel genes and pathogenic variants in families from diverse regions of Pakistan with clinically diagnosed mucopolysaccharidosis type I and mucopolysaccharidosis type II.Methods: Clinical diagnosis identified 12 with mucopolysaccharidosis I and 2 with mucopolysaccharidosis II in 14 families and whole genome sequencing (WGS) was performed to identify the causative variations in 15 affected individuals. Twenty-two unaffected individuals including parents or normal siblings of patients were also sequenced. Putative causal variants were identified by co-segregation and functional annotation.Results: Analysis of whole genome sequencing data revealed ten novel and six previously reported variants in lysosomal storage disorders-associated genes (IDUA, GALNS, SGSH, GAA, IDS, ALDOB, TRAPPC4, MASP1, SMARCAL, KIAA1109, HERC1, RRAS2) and a novel candidate gene (ABCA5) for lysosomal storage disorder-like phenotypes, which has previously been associated with symptoms strongly related with lysosomal storage disorder in animal models.Conclusion: Multigenic inheritance was found in several families highlighting the importance of searching for homozygous pathogenic variants in several genes also in families with a high degree of consanguinity.
Production performance of four lines of Japanese quail reared under tropical climatic conditions of Tamil Nadu, India
Authors: Arunrao Keche Vishal , Kannan Duraisamy , Amutha Ramasamy , Thiruvenkadan Aranganoor Kannan , Yakubu Abdulmojeed 
Published: April 2023

This research investigated the growth and other production traits of four distinct lines (L1, L2, L3, and L4) of Japanese quail (Cortunix japanoica) kept in the tropical climate of Tamil Nadu, India. The traits related to body weight at different weeks and weight gain were measured in 180 birds (90 males and 90 females) per line up to the fifth week of age, and then 90 birds (females only) from the sixth to the 16th week of age, with egg production and feed efficiency parameters measured in 10 observations per line. The traits were analysed using the General Linear Model procedure, and Tukey’s HSD was used to test for statistical differences (p &lt; 0.05) between the means for subclasses under a specific effect. The results revealed a highly significant difference (p &lt; 0.01) in body weight from hatch to fifth week of age. At 5th week of age, the L3 and L2 did not differ (p &gt; 0.05) based on Tukey test; therefore, both presented the highest values and were statistically significant (p &lt; 0.01) with L4 with a lowest value of 203.62 g. The cumulative fifth week feed conversion ratio showed non-significant difference (p &gt; 0.05) at first and second week, and highly significant difference (p &lt; 0.01) from third to fifth week of age. The age at 50 per cent egg production was 60.2 (L4), 61.4 (L2), 65.1 (L3) and 66.0 (L1) days and the L1 egg production differed significantly (p &lt; 0.01) from L4 line. The highest bodyweight (g) during the laying period (at 15 weeks of age) was observed in L2 (327.08) and L3 (326.54) and differed significantly (p &lt; 0.01) from L1 (309.24) as well as L4 (288.69) lines. The mean egg weight (g) of different lines showed non-significant difference (p &gt; 0.05) at all weeks, except at 11th week of age (p &lt; 0.01). The mean feed consumption (g)/bird/day differed significantly (p &lt; 0.01) from 6th to 16th week of age, except at sixth and eighth week of age, where it was non-significant (p &gt; 0.05). The overall feed efficiency/dozen of eggs (from 6th to 16th weeks) ranged from 1.33 (L1) to 1.98 (L3). The livability from 6 to 16 weeks of age was 100 per cent in all the lines. In order to boost Japanese quail production in the tropics, L3 and L4 may be selected for body weight and egg production, respectively.