bluuebunny/crossref_metadata_2025_split huggingface dataset:
Decision‐making of powerful CEOs on green innovation: The roles of performance feedback and institutional investors
Authors: Zhao Jianyu , Qu Jing 
Published: July 2023

AbstractThis study assesses the effects of CEO power on green innovation and, more importantly, explores how different performance feedback affects this relationship by considering the positive and negative aspects of financial and environmental performance feedback. We further discuss how institutional investors respond to the decision‐making of powerful CEOs on green innovation. By using Chinese manufacturing observations, we find that although powerful CEOs positively promote firms' green innovation, this positive effect does not apply to all conditions. The impacts of CEO power on green innovation are different under the positive and negative aspects of performance feedback, and under financial and environmental performance feedback. Accordingly, heterogeneous institutional investors respond differently to these various situations. Specifically, pressure‐resistant institutional investors serve as ‘supervisors’ under the positive aspects of financial and environmental performance feedback and shift to ‘bystanders’ under the negative aspects of financial and environmental performance feedback. Pressure‐sensitive institutional investors always act as ‘bystanders’ under different performance feedback.
Glycolipotoxicity conferred tendinopathy through ferroptosis dictation of tendon‐derived stem cells by YAP activation
Authors: Wang Gang , Wang Shikun , Ouyang Xingyu , Wang Hui , Li Xiao , Yao Zhixiao , Chen Shuai , Fan Cunyi 
Published: July 2023

AbstractTendinopathy is a condition characterized by chronic, complex, and multidimensional pathological changes in the tendons. The etiology of tendinopathy is the combination of several factors, and diabetes mellitus (DM) is a risk factor. Increasing evidence has shown that the diabetic microenvironment plays an important role in tendinopathy. However, the mechanism causing tendinopathy in patients with DM remains unclear. Our study found that ferroptosis played an important role in tendinopathy in patients with DM. In vitro, high glucose and high fat treatment was used to simulate the DM microenvironment. Results showed that such a mechanism significantly increased ferroptosis, which was characterized by mass cell death, lipid peroxide accumulation, mitochondrial morphological changes, mitochondrial membrane potential decline, iron overload, and the activation of ferroptosis‐related genes, in tendon‐derived stem cells cultured in vitro. In the animal studies, db/db mice were used in the DM model, and the db mice had severe tendon injury and high ACSL4 and TfR1 expressions. These phenomena could be alleviated by the ferroptosis inhibitor ferrostatin‐1. In conclusion, ferroptosis is associated with tendinopathy in patients with DM, and ferroptosis targeting may be a novel approach for treating diabetic tendinopathy. Our results can provide a new strategy for managing tendinopathy clinically in patients with DM.
Gene expression analyses reveal potential mechanism of inorganic arsenic‐induced apoptosis in zebrafish
Authors: Silva Camila S. , Kudlyk Tetyana , Tryndyak Volodymyr P. , Twaddle Nathan C. , Robinson Bonnie , Gu Qiang , Beland Frederick A. , Fitzpatrick Suzanne C. , Kanungo Jyotshna 
Published: July 2023

AbstractOur previous study showed that sodium arsenite (200 mg/L) affected the nervous system and induced motor neuron development via the Sonic hedgehog pathway in zebrafish larvae. To gain more insight into the effects of arsenite on other signaling pathways, including apoptosis, we have performed quantitative polymerase chain reaction array‐based gene expression analyses. The 96‐well array plates contained primers for 84 genes representing 10 signaling pathways that regulate several biological functions, including apoptosis. We exposed eggs at 5 h postfertilization until the 72 h postfertilization larval stage to 200 mg/L sodium arsenite. In the Janus kinase/signal transducers and activators of transcription, nuclear factor κ‐light‐chain‐enhancer of activated B cells, and Wingless/Int‐1 signaling pathways, the expression of only one gene in each pathway was significantly altered. The expression of multiple genes was altered in the p53 and oxidative stress pathways. Sodium arsenite induced excessive apoptosis in the larvae. This compelled us to analyze specific genes in the p53 pathway, including cdkn1a, gadd45aa, and gadd45ba. Our data suggest that the p53 pathway is likely responsible for sodium arsenite‐induced apoptosis. In addition, sodium arsenite significantly reduced global DNA methylation in the zebrafish larvae, which may indicate that epigenetic factors could be dysregulated after arsenic exposure. Together, these data elucidate potential mechanisms of arsenic toxicity that could improve understanding of arsenic's effects on human health.
Stem cell mobilizating effect of heparin in patients undergoing autologous stem cell transplantation
Authors: Merter Mustafa , Sahin Ugur , İlhan Osman , Beksac Meral 
Published: July 2023

AbstractBackgroundAdequate stem cell collection is essential for successful stem cell transplantation. Heparin enhances stem cell mobilization by competing with heparin sulfate proteoglycans. Heparin is also used as an anticoagulant before leukapheresis. Here, we evaluated the effects of heparin on stem cell mobilization in patients who underwent autologous stem cell transplantation (ASCT).MethodsWe evaluated patients who underwent ASCT. Patients were divided into two groups: those who received heparin plus citrate (heparinized patients) and those who received citrate only (nonheparinized patients) for anticoagulation. Univariate and multivariate analyses were also performed. The collection efficiency 2 (CE2) for CD34+ cells was calculated and compared between heparinized and nonheparinized patients.ResultsThis study included 1017 patients. There were 478 (47%) heparinized and 539 (53%) nonheparinized patients. The number of collected CD34+ cells was significantly higher in heparinized patients (P < .00001). The multivariate analyses showed that using heparin was an independent positive factor for collected CD34+ cells (adj‐R2 = 0.744; F = 369.331, P < .00001). CE2 was significantly higher in heparinized patients than in nonheparinized patients (66.8% vs 52.1%; P < .00001). The rate of collecting at least 2 × 106/kg CD34+ cells was 3.3 times higher for heparinized patients in poor mobilizers (P < .00001). Heparinized patients had significantly higher total nucleated and mononuclear cell counts (P < .00001 and <.00001, respectively).ConclusionHeparin enhances stem cell collection and increases CE2. The use of heparin may reduce the need for other strategies to increase stem cell mobilization.
Latent profiles of counselor burnout: Associations with self‐discrepancy
Authors: Kim Isak , Lee Donghun , Lee Janghee , Lee Sang Min 
Published: July 2023

AbstractThe purpose of this research study was to identify heterogeneous counselor burnout profiles using a latent profile analysis (LPA) and examine the profiles in association with counselors’ personal and professional self‐discrepancies in counselor qualities. Data from 360 practicing professional counselors were used for analysis. LPA identified four distinct profiles: Well‐Adjusted Counselors (n = 167, 46.4%), Disconnected Counselors (n = 68, 18.9%), Impaired Counselors (n = 22, 6.1%), and Persevering Counselors (n = 103, 28.6%). A series of Chi‐square tests indicated there were significant associations between the burnout profiles and self‐discrepancies in some counselor qualities, such as “open‐minded,” “stable,” “dependable,” “consistent,” “empathic,” “optimistic,” “trustworthy,” and “sociable.” Professional counselors are encouraged to identify their burnout profile and address personal and professional self‐discrepancy, which may affect burnout symptomology.
Solvent‐free synthesis of ZIF‐67 thin films as the catalyst for the direct growth of carbon nanotubes for the fabrication of electrical double‐layer capacitors
Authors: Lo Kai‐Hsiang , Lin Jeng‐Yu , Hsieh Chien‐Kuo 
Published: July 2023

AbstractObjectiveThis work is focused on the direct growth of vertically aligned carbon nanotubes (CNTs) onto the flexible stainless‐steel mesh (SM) substrate using ZIF‐67 as the catalytic layer.Materials & MethodsThe CNTs/SM electrode is prepared by two‐step chemical vapor deposition (CVD) method using ZIF‐67 thin films as the catalytic layers. The time duration for the deposition of ZIF‐67 thin films by an atmospheric CVD process is controlled for direct, vertically aligned, dense and uniform growth of CNTs by a low‐pressure CVD process at a low temperature of 450 °C.Results & DiscussionThe electrochemical performance of CNTs/SM electrode is studied by cyclic voltammetry and galvanostatic charge/discharge measurements using KOH aqueous electrolyte which showed their better EDLC features and outstanding rate capability. The binder‐free directly grown CNTs/SM electrode displayed a low interfacial resistance between CNTs and SM substrate which comes from their synergistic effect of lower charge loss and better charge collection. Moreover, vertically aligned one‐dimensional CNTs could be rendered as the charge highway in the axial direction, which can promote the rapid charge transportation.ConclusionsThe directly grown CNTs on the commercial SM substrate using the ZIF‐67 catalytic layer fabricated via the solvent free technology can be regarded as a promising EDLC electrode for flexible super capacitors.
Effect of sex differences and time of oxytocin administration on treatment of rat model of autism spectrum disorder: Focused on necroptosis markers
Authors: Shariatpanahi Marjan , Sojoudi Zahra , Khodagholi Fariba , Rahmati Hiva , Jameie Seyed Behnamedin , Eftekharzadeh Mina , Karizmeh Maryam Soleimani , Shabani Mostafa , Zamani Ehsan 
Published: July 2023

AbstractAutism is a neurodevelopmental disorder. A variety of molecular and cellular abnormalities leads to behavioral deficits in autism. Nevertheless, its etiology and treatment strategy are not completely understood. Oxytocin has recently shown improvements in social functioning. This study aimed to evaluate the necroptosis pathway for the neuroprotective effects of oxytocin in the valproic acid‐induced autism spectrum disorder model. The autism spectrum disorder was induced by valproic acid on gestational day 12.5 (600 mg/kg, intraperitoneally). Offspring received intranasal oxytocin (1 μg/μL) on the 21st and 40th days after birth. The offspring behaviors were scrutinized by self‐grooming, marble‐burying, three‐chamber, and Morris water maze tests. Western blot was performed on the hippocampus and amygdala tissues to investigate the expression of RIP3 and MLKL markers. The valproic acid group demonstrated more anxiety, repetitive behaviors, and expression of RIP3 and MLKL markers, and less social interaction and spatial memory compared with the control group. Oxytocin considerably improved social interactions, preference for social novelty, and memory. The elevated expression of RIP3 and MLKL markers in valproic acid‐induced autistic rats were alleviated after treatment with oxytocin. We also highlighted the importance of age and gender in autism spectrum disorder interventions. Our findings suggested that oxytocin administration was as an effective treatment in two areas of repetitive/stereotyped behaviors, social interactions/cognitive function. Notably, early administration of oxytocin resulted in better therapeutic responses in autism‐like behaviors. The molecular tests introduce oxytocin as a potential candidate for reducing the expression of necroptosis mediators in the brain. This reinforced our hypothesis that the necroptosis pathway takes part in autism spectrum disorder.
Retracted: Assessment of HBV infection and inter‐host cellular responses using intrahepatic cholangiocyte organoids
Authors: Lim Chuan Kok , Tran Bang Manh , Flanagan Dustin , McCartney Erin , Tse Edmund , Vincan Elizabeth 
Published: July 2023

AbstractIntrahepatic cholangiocyte organoids (ICOs) model was evaluated for host differences in hepatitis B virus (HBV) infection, cellular responses, antiviral, and immunomodulator responses. Twelve ICOs generated from liver resections and biopsies were assessed for metabolic markers and functional HBV entry receptor expression throughout differentiation. Structural changes relevant to HBV infection were characterized using histology, confocal, and electron microscopy examinations. Optimal ICO culture conditions for HBV infection using HepAD38 (genotype D) and plasma derived HBV (genotype B & C) were described. HBV infection was confirmed using HBcAg immunostaining, qRT‐PCR (RNA, cccDNA, extracellular DNA), and ELISA (HBsAg and HBeAg). Drug response to antiviral and immunosuppressive agent, and cellular responses (interferon‐stimulated genes [ISG]) to interferon‐α and viral mimic (PolyI:C) were assessed. ICOs underwent metabolic and structural remodeling following differentiation. Optimal HBV infection was achieved in well‐differentiated ICOs using spinoculation, with time and donor dependent increase in HBV RNA, cccDNA, extracellular DNA, HBeAg, and HBsAg. Donor dependent drug‐responsiveness to entry inhibitor and JAK inhibitor was observed. Despite having a robust ISG response to interferon‐α and PolyI:C, HBV infection in ICOs did not upregulate ISGs. Human ICOs support HBV infection and replication with donor dependent variation in viral dynamics and cellular responses. These features can be utilized for development of personalized drug testing platform for antivirals.
Determinants of protection against SARS‐CoV‐2 Omicron BA.1 and Delta infections in fully vaccinated outpatients
Authors: Roy Alvaro , Saade Carla , Josset Laurence , Clément Bénédicte , Morfin Florence , Destras Grégory , Valette Martine , Icard Vinca , Billaud Geneviéve , Oblette Antoine , Debombourg Marion , Garrigou Christine , Brengel‐Pesce Karen , Generenaz Laurence , Saker Kahina , Hernu Romain , Pozzetto Bruno , Lina Bruno , Trabaud Mary‐Anne , Trouillet‐Assant Sophie , Bal Antonin 
Published: July 2023

AbstractWe aimed to evaluate the association between the humoral and cellular immune responses and symptomatic SARS‐CoV‐2 infection with Delta or Omicron BA.1 variants in fully vaccinated outpatients. Anti‐receptor binding domain (RBD) IgG levels and interferon‐gamma (IFN‐γ) release were evaluated at PCR‐diagnosis of SARS‐CoV‐2 in 636 samples from negative and positive patients during Delta and Omicron BA.1 periods. Median levels of anti‐RBD IgG in positive patients were significantly lower than in negative patients for both variants (p < 0.05). The frequency of Omicron BA.1 infection in patients with anti‐RBD IgG concentrations ≥1000 binding antibody units (BAU)/mL was 51.0% and decreased to 34.4% in patients with concentrations ≥3000 BAU/mL. For Delta infection, the frequency of infection was significantly lower when applying the same anti‐RBD IgG thresholds (13.3% and 5.3% respectively, p < 0.05). In addition, individuals in the hybrid immunity group had a 4.5 times lower risk of Delta infection compared to the homologous vaccination group (aOR = 0.22, 95% CI: [0.05−0.64]. No significant decrease in the risk of Omicron BA.1 infection was observed in the hybrid group compared to the homologous group, but the risk decreased within the hybrid group as anti‐RBD IgG titers increased (aOR = 0.08, 95% CI: [0.01−0.41], p = 0.008). IFN‐γ release post‐SARS‐CoV‐2 peptide stimulation was not different between samples from patients infected (either with Delta or Omicron BA.1 variant) or not (p > 0.05). Our results show that high circulating levels of anti‐RBD IgG and hybrid immunity were independently associated with a lower risk of symptomatic SARS‐CoV‐2 infection in outpatients with differences according to the infecting variant (www.clinicaltrials.gov; ID NCT05060939).
Multimodal microscope system for hyperspectral imaging of scattering directionality and Raman excitation spectroscopy
Authors: Amirsalari Abdolvahab , Razi Sepehr , Gawinkowski Sylwester 
Published: July 2023

AbstractPlasmonic nanostructures enable the strong localization of an electromagnetic field, which allows them to be used for enhancing Raman signals. This property has a range of applications in various fields, from detecting small quantities of substances to studying the interactions between compounds and metals. Although the general mechanism of Raman signal enhancement by metal nanoparticles is accepted, details related to the interaction of the nanoparticle with the molecule are still unexplained because of its complexity. A versatile, high‐resolution microscope system is required to investigate the spectroscopic properties of nanoparticles and the Raman signals enhanced by them. This study describes a multifunctional microscope system designed for comprehensive microspectroscopic analysis of plasmonic nanostructures functionalized with chemicals. The integrated system combines various excitation and detection modalities, enabling hyperspectral Raman mapping, Rayleigh (dark‐field) scattering hyperspectral mapping, and angular scattering and emission mapping in defocused mode. The flexibility in excitation wavenumber choice ensures optimal measurement efficiency and the ability to perform all measurements as a function of excitation. We demonstrate the system's capabilities using malachite green deposited on gold nanorods, showcasing the surface‐enhanced Raman scattering (SERS) excitation profiles and scattering directionality defocused imaging using the hyperspectral imaging of the angular distribution of Raman scattering technique. This integrated microscope system promises to advance the study of plasmonic nanostructures and their interactions with chemical compounds at the single‐particle level. The construction of a multimodal Raman microscopic system that enables hyperspectral imaging of the angular distribution of Raman scattering and dark‐field scattering, as well as Raman excitation profiles, is presented. The capabilities of the system are demonstrated by studying the surface‐enhanced Raman scattering of malachite green deposited on gold nanorods.
A comparative study of the image quality of dermoscopic images acquired in general practice versus at a dermatology department
Authors: Niklasson Louise , Prasad Sumangali Chandra , Schuster Annette , Laurinaviciene Rasa , Vestergaard Tine 
Published: July 2023

AbstractBackgroundSkin cancer constitutes a significant and growing disease burden. To deal with this, teledermoscopy (TDS) can be useful. However, image quality is a concern for implementing TDS. High image quality can be obtained at a dermatology department, but in many occasions, it is more sensible to acquire TDS images in general practice.ObjectivesTo compare image quality, diagnostic confidence, suggested management, sensitivity, specificity and diagnostic accuracy between two sets of dermoscopic images of the same skin tumour, where one set was acquired in general practice, and the other was obtained at a dermatology department.MethodsTwo sets of dermoscopic images of 192 skin lesions were evaluated by the same dermatologist at two different occasions approximately 4 years apart (2018 vs. 2022). On both occasions, the images were evaluated in regard to image quality, diagnostic confidence, whether the lesion was a benign or malignant, primary diagnosis and suggested management.ResultsThere were statistically significant differences of diagnostic confidence and suggested management (p = 0.00 for respective parameter), but not for image quality (p = 0.37), sensitivity (p = 0.67), specificity (p = 0.66) and diagnostic accuracy (p = 0.81). The intraobserver agreements were slight for image quality (κ = 0.012), fair for diagnostic confidence (κ = 0.313) and moderate for suggested management (κ = 0.467).ConclusionsThe image quality of both sets of dermoscopic images was most often good. Although we did not find a statistically significant difference in image quality between the two sets of images, our minimal level of intraobserver agreement suggests otherwise. However, this should not hinder TDS image acquisition in general practice as our results indicate that with the availability of referral notes, TDS images taken in general practice can achieve a similar sensitivity, specificity and diagnostic accuracy as dermoscopic images obtained at a dermatology department.
Breeding records, urban habitat, and threats to the masked palm civet in Taiwan
Authors: Lim Pin Xuan , Lin Si‐Min , Lin Wen‐Loung , Tseng Hui‐Yun 
Published: July 2023

AbstractAn increasing number of mammalian species worldwide have adapted to urban environments following the alteration and fragmentation of natural habitats. In recent years, the masked palm civet (Paguma larvata) has increased in several highly populated cities in Taiwan. Twelve‐years (2010–2021) of civet records in Taichung (the largest city in central Taiwan) from the rescue center of Taichung Wildlife Conservation Group report the population of civets has grown steadily since 2017, with the number of records in 2020 (n = 58) and 2021 (n = 55) approximately 5 times of that in 2010–2014 (mean ± SD = 5.0 ± 2.6). Our objective was to use the records from the rescue center to evaluate the potential sexual dimorphism of urban civets, explore temporal variation of civet activity and age structure, identify major threats to civets inhabiting urban areas, and investigate the environmental characteristics surrounding civet nesting sites in urban environments. The civet breeding season lasts from spring to autumn, with primary mating season in spring. The main cause of mortality in adults was dog attack followed by car accident, while the main rescue reason for young civets was because they were considered orphans following human interferences. Many civets in urban areas inhabit locations where >90% of the land cover is covered by buildings and man‐made structures, and even nest inside buildings. Our results demonstrated the need for new civet conservation and management policies to minimize dog attacks on civets to enhance co‐existence between wildlife and humans.
Poly (Ionic Liquid)‐Metal Organic Framework‐Derived Nanoporous Carbon Membranes: Facile Fabrication and Ultrahigh Areal Capacitance
Authors: Shi Yu , Long Wenhua , Wang Yue , He Xuelong , Lv Baokang , Zuo Hongyu , Li Xinghao , Liao Yaozu , Zhang Weiyi 
Published: July 2023

AbstractWith the rapid development of energy storage technology, the operation of portable and wearable devices is inseparable from high energy density power supplies. However, the demand for high performance supercapacitors in movable smart electronics is still restrained by their insufficient areal capacitance and limited power/energy densities. In addition, some electroactive materials, including metal oxides, conductive polymers, graphene, porous carbons, etc., are inevitable to use extra adhesives for the preparation of electrode materials. In this work, integrated hierarchical graphitic porous carbon membranes used as the electrodes without adhesives are successfully synthesized, via pyrolyzing poly(ionic liquid)s (PILs)‐metal organic frameworks (MOFs) composite membranes. The asymmetric supercapacitor is assembled by the carbonized PIL‐MOF composite membrane and PILs‐derived porous carbon membrane, and exhibits significant areal capacitance with remarkable power and energy densities. In the two‐electrode system, the areal capacitance can reach 9.5 F cm−2 with an energy density of 1.91 mWh cm−2. In the fabricated all‐solid‐state supercapacitors, the areal capacitance and energy density achieved 3.2 F cm−2 and 0.65 mWh cm−2, respectively, exceeding most reported ones. Therefore, the integrated carbon membrane electrodes with high areal capacitance reveal great potential in miniaturized devices, and further show a wider application scope through regulating PILs.