bluuebunny/crossref_metadata_2025_split huggingface dataset:
High prevalence of pre-eclampsia in women with coarctation of the aorta
Authors: Gronningsaeter Lasse , Langesaeter Eldrid , Sørbye Ingvil Krarup , Quattrone Alessia , Almaas Vibeke Marie , Skulstad Helge , Estensen Mette-Elise 
Published: July 2023

Abstract

Aims
The aim was to study pregnancy outcomes in women with coarctation of the aorta (CoA) and associations to hypertensive disorders of pregnancy. Maternal morbidity and mortality are higher in women with heart disease and pre-eclampsia. Chronic hypertension, frequently encountered in CoA, is a risk factor for pre-eclampsia.

Methods and results
Clinical data from the National Unit for Pregnancy and Heart Disease database was reviewed for pregnant women with CoA from 2008 to 2021. The primary outcome was hypertensive pregnancy disorders. The secondary outcomes were other cardiovascular, obstetric, and foetal complications. Seventy-six patients were included, with a total of 87 pregnancies. Seventeen (20%) patients were treated for chronic hypertension before pregnancy. Fifteen (20%) patients developed pre-eclampsia, and 5 (7%) had pregnancy-induced hypertension. Major adverse cardiac events developed in four (5%) patients, with no maternal or foetal mortality. Maternal age at first pregnancy [odds ratio (OR) 1.37], body mass index before first pregnancy (OR 1.77), and using acetylsalicylic acid from the first trimester (OR 0.22) were statistically significantly associated with pre-eclampsia. At follow-up (median) 8 years after pregnancy, 29 (38%) patients had anti-hypertensive treatment, an increase of 16% compared to pre-pregnancy. Five (7%) patients had progression of aorta ascendens dilatation to &gt;40 mm, seven (9%) had an upper to lower systolic blood pressure gradient &gt;20 mmHg, and six (8%) had received CoA re-intervention.

Conclusion
Pre-eclampsia occurred in 20% of women with CoA in their first pregnancy. All pre-eclamptic patients received adequate anti-hypertensive treatment. All CoA patients were provided multi-disciplinary management, including cardiologic follow-up, to optimize maternal–foetal outcomes.
Myocardial recovery in children supported with a durable ventricular assist device—a systematic review
Authors: Rohde Sofie , de By Theo M M H , Bogers Ad J J C , Schweiger Martin 
Published: July 2023

Abstract

OBJECTIVES
A small percentage of paediatric patients supported with a ventricular assist device (VAD) can have their device explanted following myocardial recovery. The goal of this systematic review is to summarize the current literature on the clinical course in these children after weaning.

METHODS
A systematic literature search was performed on 27 May 2022 using Embase, Medline ALL, Web of Science Core Collection, Cochrane Central Register of Controlled Trials and Google Scholar to include all literature on paediatric patients supported by a durable VAD during the last decade. Overlapping study cohorts and registry-based studies were filtered out.

RESULTS
Thirty-seven articles were included. Eighteen of them reported on the incidence of recovery in cohort studies, with an overall incidence rate of 8.7% (81/928). Twenty-two of the included articles reported on clinical outcomes after VAD explantation (83 patients). The aetiologies varied widely and were not limited to diseases with a natural transient course like myocarditis. Most of the patients in the included studies (70; 84.3%) were supported by a Berlin Heart EXCOR, and in 66.3% (55/83), only the left ventricle had to be supported. The longest follow-up period was 19.1 years, and multiple studies reported on long-term myocardial recovery. Fewer than half of the reported deaths had a cardiac cause.

CONCLUSIONS
Myocardial recovery during VAD support is dependent on various contributing components. The interactions among patient-, device-, time- and hospital-related factors are complex and not yet fully understood. Long-term recovery after VAD support is achievable, even after a long duration of VAD support, and even in patients with aetiologies different from myocarditis or post-cardiotomy heart failure. More research is needed on this favourable outcome after VAD support.
Credit expansion, leverage, and banking distress: the puzzle of interwar Italy
Authors: Molteni Marco 
Published: July 2023

Abstract
This study analyses the relationship between lending growth, leverage, and distress at the individual bank level for interwar Italy, which experienced remarkable credit expansion in the 1920s. Novel data from archival research based on banking supervision classified documents reveals a large, albeit forgotten, crisis. A puzzle emerges: regression analysis on individual bank balance sheets indicates that leverage and lending growth are not predictors of distress. Complementary indicators show that the features highlighted in the literature on leveraged credit booms do not apply to Italy. Italy’s credit expansion was not a leverage-fuelled credit boom but a process of financial development.
Genetic dissection of morphological variation between cauliflower and a rapid cycling Brassica oleracea line
Authors: Shuang Lan Shuan , Cuevas Hugo , Lemke Cornelia , Kim Changsoo , Shehzad Tariq , Paterson Andrew H 
Published: July 2023

Abstract
To improve resolution to small genomic regions and sensitivity to small-effect loci in the identification of genetic factors conferring the enlarged inflorescence and other traits of cauliflower while also expediting further genetic dissection, 104 near-isogenic introgression lines (NIILs) covering 78.56% of the cauliflower genome, were selected from an advanced backcross population using cauliflower [Brassica oleracea var. botrytis L., mutant for Orange gene (ORG)] as the donor parent and a rapid cycling line (TO1434) as recurrent parent. Subsets of the advanced backcross population and NIILs were planted in the field for 8 seasons, finding 141 marker-trait associations for 15 leaf-, stem-, and flower-traits. Exemplifying the usefulness of these lines, we delineated the previously known flower color gene to a 4.5 MB interval on C3; a gene for small plant size to a 3.4 MB region on C8; and a gene for large plant size and flowering time to a 6.1 MB region on C9. This approach unmasked closely linked QTL alleles with opposing effects (on chr. 8) and revealed both alleles with expected phenotypic effects and effects opposite the parental phenotypes. Selected B. oleracea NIILs with short generation time add new value to widely used research and teaching materials.
A Reference Genome Assembly for the Spotted Flycatcher (Muscicapa striata)
Authors: Baudrin Gaspard , Pons Jean-Marc , Bed’Hom Bertrand , Gil Lisa , Boyer Roxane , Dusabyinema Yves , Jiguet Frédéric , Fuchs Jérôme 
Published: July 2023

Abstract
The spotted flycatcher (Muscicapa striata) forms with the Mediterranean flycatcher (Muscicapa tyrrhenica) a newly recognized species pair of trans-Saharan migratory passerines. These flycatchers present a nested peripatric distribution, a pattern especially unusual among high dispersal species that questions the eco-evolutionary factors involved during the speciation process. Here, we present a genome assembly for M. striata assembled using a combination of Nanopore and Illumina sequences. The final assembly is 1.08 Gb long and consists of 4,779 contigs with an N50 of 3.2 Mb. The completeness of our M. striata genome assembly is supported by the number of BUSCO (95%) and ultraconserved element (UCE) (4889/5041; 97.0%) loci retrieved. This assembly showed high synteny with the Ficedula albicollis reference genome, the closest species for which a chromosome-scale reference genome is available. Several inversions were identified and will need to be investigated at the family level.
Making Home: The Role of Social Networks on Identity, Health, and Quality of Life Among Rural Lesbian and Gay Older Adults
Authors: Guest Marc Aaron , Hunter Elizabeth G , Schoenberg Nancy E 
Published: July 2023

Abstract

Background and Objectives
Gay and lesbian older persons face a host of health inequalities related to their identity as they age. Challenges to health access and appropriate social support may be even more exacerbated for those living in rural environments; this may be due to the lack of supportive and affirming social connections. This project aimed to explore and describe the social networks and the relationship of these social networks to identity, health, and quality of life of gay and lesbian individuals in rural communities.

Research Design and Methods
Social network data on network type, size, and social capital were collected and supplemented by quantitative questionnaires relating to health, quality of life, marginalization, and identity.

Results
Participants (N = 25) were recruited from three states. Thirteen participants self-identified as gay and 12 as lesbian. All but one identified as non-Hispanic White. The average age of all participants was 60.32 years. Findings indicate that rural gay and lesbian individuals develop networks with little consideration for network members’ acceptance of their identity. Participants reported an average network size of 9.32 individuals. Gay men reported higher perceptual affinity (.69) than lesbian participants (.62). Lesbian networks showed significantly (p = .0262) greater demographic similarity (.58) than aging gay men’s networks (.55). Aging gay men (.89) reported statistically stronger (p = .0078) network ties than aging lesbian females (.78). Among participants in this study, network size is not correlated with the health and quality of life of rural aging lesbian and gay individuals. Still, personal identity congruence does appear to relate to health and quality of life.

Discussion and Implications
The findings highlight the collective need to continue research into sexual minority aging and rural sexual minority aging, particularly employing novel methods.
Innovations for an Aging Society through the Lens of Patent Data
Authors: Ng Reuben , Indran Nicole 
Published: July 2023

Abstract

Background and Objectives
An aging population creates fertile ground for devising innovations for older adults. By using patents as a proxy for inventive activity, this study sets the stage for understanding the latest innovations being designed for the older population. Insights will pave the way for a better understanding of inventions that could render society more age-friendly on the innovation front.

Research Design and Methods
To identify the latest innovations targeted at the older population, we collected all patents (N = 326) issued in 2021, specifically those issued between January 5th and December 28th. Upon removing irrelevant data, 120 patents were retained in the data set. Both inductive and deductive modes of reasoning informed our content analysis of the data.

Results
Three themes surfaced. About half (49.2%) of the patents focused on “Preventive Health, Safety, and Independence” (Theme 1). About 38.3% pertained to “Anti-Aging” (Theme 2) and 12.5% were about the “Pathologization of Old Age” (Theme 3).

Discussion and Implications
This is the first study that evaluates the state of innovations for an aging population. While there are inventions aimed at optimizing the well-being of older adults, there are also those designed due to beliefs that see old age as a problem to solve. As the world experiences a demographic shift, it is imperative that collective ingenuity be harnessed to build a society conducive to all facets of the aging experience.
Warmer temperature during asexual reproduction induce methylome, transcriptomic, and lasting phenotypic changes in Fragaria vesca ecotypes
Authors: Zhang(张宇鹏) YuPeng , Fan Guangxun , Toivainen Tuomas , Tengs Torstein , Yakovlev Igor , Krokene Paal , Hytönen Timo , Fossdal Carl Gunnar , Grini Paul E. 
Published: July 2023

Abstract
Plants must adapt with increasing speed to global warming to maintain their fitness. One rapid adaptation mechanism is epigenetic memory, which may provide organisms sufficient time to adapt to climate change. We studied how the perennial Fragaria vesca adapted to warmer temperatures (28°C vs. 18°C) over three asexual generations. Differences in flowering time, stolon number, and petiole length were induced by warmer temperature in one or more ecotypes after three asexual generations and persisted in a common garden environment. Induced methylome changes differed between the four ecotypes from Norway, Iceland, Italy, and Spain, but shared methylome responses were also identified. Most differentially methylated regions (DMRs) occurred in the CHG context, and most CHG and CHH DMRs were hypermethylated at the warmer temperature. In eight CHG DMR peaks, a highly similar methylation pattern could be observed between ecotypes. On average, 13% of the differentially methylated genes between ecotypes also showed a temperature-induced change in gene expression. We observed ecotype-specific methylation and expression patterns for genes related to gibberellin metabolism, flowering time, and epigenetic mechanisms. Furthermore, we observed a negative correlation with gene expression when repetitive elements were found near (±2 kb) or inside genes. In conclusion, lasting phenotypic changes indicative of an epigenetic memory were induced by warmer temperature and were accompanied by changes in DNA methylation patterns. Both shared methylation patterns and transcriptome differences between F. vesca accessions were observed, indicating that DNA methylation may be involved in both general and ecotype-specific phenotypic variation.
Dioscin Activates Endoplasmic Reticulum Unfolded Protein Response for Defense Against Pathogenic Bacteria in Caenorhabditis elegans via IRE-1/XBP-1 Pathway
Authors: Xiao Yi , Liu Fang , Wu Qinyi , Zhu Xinting , Yu Changyan , Jiang Nian , Li Sanhua , Liu Yun 
Published: July 2023

Abstract
The unfolded protein response (UPR) is an evolutionarily conserved pathway that senses and responds to the accumulation of misfolded proteins in the endoplasmic reticulum (ER) lumen during bacterial infection. The IRE-1/XBP-1 pathway is a major branch of the UPRER that has been conserved from yeast to human. Dioscin, a steroidal saponin exhibits a broad spectrum of properties. However, whether dioscin influences the immune response and the underlying molecular mechanisms remain obscure. We find that dioscin increases resistance to Gram-negative pathogen Pseudomonas aeruginosa. Furthermore, dioscin also inhibits the growth of pathogenic bacteria. Meanwhile, dioscin enhances the resistance to pathogens by reducing bacterial burden in the intestine. Through genetic screening, we find that dioscin activates the UPRER to promote innate immunity via IRE-1/XBP-1 pathway. Intriguingly, dioscin requires the neural XBP-1 for immune response. Our findings suggest that dioscin may be a viable candidate for the treatment of infectious diseases.
Prevalence of Modifiable Breast Cancer Risk Factors and Potential Opportunities for Primary Prevention Among Women Engaged in Screening Mammography: National Health Interview Survey Results
Authors: Chowdhry Divya N , Miles Randy C , Escamilla Guevara Antonio , Flores Efren J , Narayan Anand K 
Published: July 2023

Abstract

Objective
To determine the prevalence of modifiable breast cancer risk factors among women engaged in screening mammography using nationally representative cross-sectional survey data and to inform potential opportunities for breast facilities to contribute to primary prevention.

Methods
2018 National Health Interview Survey respondents who were women ages 40–74 years without history of breast cancer were included and then categorized based on whether they reported screening mammography within the prior two years. Proportions of these women reporting evidence-based modifiable breast cancer risk factors, including elevated body mass index (BMI), lack of physical activity, or moderate or heavy alcohol consumption were calculated and stratified by demographics. Multivariable logistic regression was used to estimate the association between these risk factors and sociodemographic characteristics.

Results
Among 4989 women meeting inclusion criteria and reporting screening mammography, 79% reported at least one modifiable risk factor. Elevated BMI was the most reported risk factor (67%), followed by lack of physical activity (24%) and alcohol consumption (16%). The majority of each race/ethnicity category reported at least one modifiable risk factor, with the highest proportion reported by Black respondents (90%). Asian, college educated, and higher-income participants were less likely to have at least one modifiable risk factor.

Conclusion
Modifiable breast cancer risk factors are prevalent among women engaged in screening mammography. This provides potential opportunities for breast imaging facilities to contribute to the primary prevention of breast cancer by providing resources for lifestyle modification at the time of screening mammography.
Metaheuristic algorithms for a sustainable saffron supply chain network considering government policies and product quality under uncertainty
Authors: Sogandi Fatemeh , Shiri Mahdyeh 
Published: July 2023

Abstract
Iranian saffron products hold a unique place in the global market as the most highly valued agricultural and medicinal commodities. The various uses of saffron make it clear that there is a need for special attention to the supply chain network. Unfortunately, the absence of an integrated supply chain network within the saffron industry has resulted in significant challenges related to supply management and demand fulfillment. Addressing real-world uncertainties is paramount when developing models for optimization problems. Therefore, this research proposes a multi-objective optimization model for designing a saffron supply chain network under uncertainty. The model objectives are to decrease the total cost of the supply chain, increase job opportunities and economic development in regions, and improve the quality of products. The proposed mathematical model is solved using the interactive fuzzy method to deal with multiple functions. Furthermore, possibilistic chance constrained programming is employed to effectively manage uncertain variables such as demand, cost, and social parameters within the model. To demonstrate the applicability and validity of the proposed model and solution method, a real case study was conducted in Khorasan Razavi province, Iran. Additionally, because of the complexity of the proposed model in large-scale networks, non-dominated sorting genetic algorithm-II and multi-objective simulated annealing algorithms are proposed. Different parameters are analyzed to determine their impact on the results so that decision-makers can choose values more accurately. The sensitivity analysis and statistical tests performed on the results support the performance of the proposed model. Overall, the results demonstrate that the exact method and metaheuristic algorithms are capable of solving the problem in different dimensions. The computational results derived from this model offer invaluable managerial insights, empowering decision-makers to align their strategies and preferences more effectively.
Species differences in hormonally mediated gene expression underlie the evolutionary loss of sexually dimorphic coloration inSceloporuslizards
Authors: Robinson Christopher D , Hale Matthew D , Wittman Tyler N , Cox Christian L , John-Alder Henry B , Cox Robert M 
Published: July 2023

AbstractPhenotypic sexual dimorphism often involves the hormonal regulation of sex-biased expression for underlying genes. However, it is generally unknown whether the evolution of hormonally mediated sexual dimorphism occurs through upstream changes in tissue sensitivity to hormone signals, downstream changes in responsiveness of target genes, or both. Here, we use comparative transcriptomics to explore these possibilities in 2 species of Sceloporus lizards exhibiting different patterns of sexual dichromatism. Sexually dimorphic S. undulatus develops blue and black ventral coloration in response to testosterone, while sexually monomorphic S. virgatus does not, despite exhibiting similar sex differences in circulating testosterone levels. We administered testosterone implants to juveniles of each species and used RNAseq to quantify gene expression in ventral skin. Transcriptome-wide responses to testosterone were stronger in S. undulatus than in S. virgatus, suggesting species differences in tissue sensitivity to this hormone signal. Species differences in the expression of genes for androgen metabolism and sex hormone-binding globulin were consistent with this idea, but expression of the androgen receptor gene was higher in S. virgatus, complicating this interpretation. Downstream of androgen signaling, we found clear species differences in hormonal responsiveness of genes related to melanin synthesis, which were upregulated by testosterone in S. undulatus, but not in S. virgatus. Collectively, our results indicate that hormonal regulation of melanin synthesis pathways contributes to the development of sexual dimorphism in S. undulatus, and that changes in the hormonal responsiveness of these genes in S. virgatus contribute to the evolutionary loss of ventral coloration.
Multigrid accelerated projection method on GPU cluster for the simulation of turbulent flows
Authors: Chiu Tzu-Hsuan , Lin Chao-An 
Published: July 2023

ABSTRACT
A graphics processing unit (GPU)-enabled numerical procedure based on the projection method is developed for simulating incompressible turbulent flows. The pressure Poisson equation is efficiently solved using the V-cycle geometric multigrid method. Additionally, the coarse grid aggregation (CGA) technique enhances the multigrid level of multi-GPU simulations, resulting in significant performance improvements. The validity of the proposed method is confirmed through direct numerical simulations of the turbulent lid-driven cavity flows at a Reynolds number of 3200. The computed mean, and turbulence quantities closely match the available measured data, validating the accuracy of the approach. For the cubic cavity under consideration, the optimized minimum grid sizes for multigrid and CGA are determined to be 83 and 323, respectively. An additional speedup of approximately ≈2.3 to ≈2.6 is achieved by employing CGA. In terms of performance, the current implementation demonstrates compatibility with the lattice Boltzmann method while also being three times faster than the explicit weakly compressible scheme. The superior performance of the GPU implementation over CPU is further highlighted, with a remarkable one thousandfold speedup observed between the Nvidia Tesla V100 and a single core of the Intel I7-6900K (8 cores). Specifically, the performance of one Tesla V100 is found to be equivalent to 125 I7-6900K central processing units.
Cystic squamous metaplasia in a giant benign phyllodes tumor of the breast: a case report
Authors: Niyonkuru Evrard , Nisabwe Simon , Sami Zineb , Faizi Issam , Mazti Asmae , Elkarroumi Mohamed , Karkouri Mehdi 
Published: July 2023

Abstract
Phyllodes tumor is a rare tumor of the breast, which encompasses both stromal and epithelial components. In these components, metaplastic changes can be observed occasionally. We report the case of a 51-year-old woman nulligest menopaused who presented a huge mass, largely ulcerated in her right breast. The radiological examination revealed a large tumor with microcalcifications classified as Breast Imaging and Reporting Data System Category 5. The patient undergone right mastectomy and the histological analysis revealed benign phyllodes tumor with cystic squamous metaplasia. Therefore, we aim to present this uncommon event occasionally occurring in phyllodes tumor of the breast.