bluuebunny/crossref_metadata_2025_split huggingface dataset:
Retroperitoneal hibernoma resected via laparoscopic surgery
Authors: Sujino Hiroki , Kasahara Kenta , Tanigawa Maki , Enomoto Masanobu , Udo Ryutaro , Tago Tomoya , Okazaki Naoto , Mazaki Junichi , Ishizaki Tetsuo , Nagao Toshitaka , Katsumata Kenji , Tsuchida Akihiko , Nagakawa Yuichi 
Published: January 2023

AbstractHibernomas are extremely rare, benign tumors of brown fat origin with no specific symptoms. Surgery is the only treatment option, and because a definitive preoperative diagnosis is often not obtained, open surgery is usually chosen. In this case, we performed laparoscopic surgery on a 33‐year‐old woman with retroperitoneal hibernoma. As in most cases, a definitive diagnosis had not been preoperatively made; therefore, we laparoscopically removed the retroperitoneal tumor of unknown pathology as a diagnostic treatment. We chose laparoscopic surgery because of the magnifying effect of the laparoscope and to minimize scarring. The surgery was uneventful, with a procedure time of 280 minutes and a blood loss of 20 mL. The postoperative course was uneventful with no complications or recurrence. We conclude that laparoscopic surgery may be a viable option for hibernomas.
What triggers depressive symptoms among gay and bisexual men? A sequential mediation model of sexual minority‐related stigma and self‐criticism
Authors: He Along , Bu He , Liao Ankang , Mu Wenlong 
Published: January 2023

AbstractA growing number of studies has shown that gay and bisexual men are more likely to experience adverse mental health status than their heterosexual counterparts. Stigma‐related stress and self‐criticism are believed likely to exacerbate depressive symptoms among gay and bisexual men. This research used cross‐sectional findings to illustrate the mediating role of internalized self‐stigma and self‐criticism in the association between perceived public stigma and depressive symptoms. A total of 317 Chinese gay and bisexual men (267 gays and 50 bisexuals with a mean age of 25.29) were invited to participate in this study from October to November 2021. Sociodemographic characteristics, perceived public stigma, internalized self‐stigma, self‐criticism and depressive symptoms were measured through self‐reported online questionnaires. The results indicated that the association between perceived public stigma and depressive symptoms was sequentially mediated by internalized self‐stigma and self‐criticism. The findings indicated that public stigma, as a distal stressor, was perceived and internalized as self‐stigma by gay and bisexual men. This self‐stigma may pose a risk for depressive symptoms via self‐criticism (a maladaptive consequence of their attempts to reduce cognitive dissonance). These results highlight the necessity of reducing sexual minority‐related stigma and self‐criticism to reduce depressive symptoms. Our findings appeal to society to further decrease prejudice and stigma, increase tolerance, and focus on the negative mental health status of gay and bisexual men.
Effects of medications on hypoxia‐inducible factor in the retina: A review
Authors: Kim Angela H. , Kolesnikova Masha , Ngo Wei Kiong , Tsang Stephen H. 
Published: January 2023

AbstractHypoxia‐inducible factor (HIF) plays a critical role in the mechanisms that allow cells to adapt to various oxygen levels in the environment. Specifically, HIF‐1⍺ has shown to be widely involved in cellular repair, survival, and energy metabolism. HIF‐1⍺ has also been found in increased levels in cancer cells, highlighting the importance of balance in the hypoxic response. Promoting HIF‐1⍺ activity as a potential therapy for degenerative diseases and inhibiting HIF‐1⍺ as a therapy for pathologies with overactive cell proliferation are actively being explored. Digoxin and metformin, HIF‐1⍺ inhibitors, and deferoxamine and ⍺‐ketoglutarate analogues, HIF‐1⍺ activators, are being studied for application in age‐related macular degeneration, diabetic retinopathy, and retinitis pigmentosa. However, these same medications have retinal toxicities that must be assessed before implementation of therapeutic care. Herein, we highlight the duality of therapeutic and toxic potential of HIF‐1⍺ that must be carefully assessed prior to its clinical application in retinal disorders.
Myopic macular diseases: A review
Authors: Ng Danny S. C. , Chan Leo K. Y. , Lai Timothy Y. Y. 
Published: January 2023

AbstractRecent evidence has demonstrated that the global public health burden of myopia is rising rapidly. Highly myopic eyes are associated with increased frequency of eye disorders that can lead to irreversible visual impairment. With recent technological advancement in ophthalmic imaging modalities, various macular complications associated with pathologic myopia are being elucidated. The development and progression of myopic chorioretinal atrophy, myopic macular neovascularization, myopic traction maculopathy and dome‐shaped macula are vision‐threatening myopic macular diseases. In order to overcome the challenges in managing patients with pathologic myopia, it is important to have a complete understanding in the natural course of these myopic macular diseases. Standardising the classification criteria of pathologic myopia is essential for enhancing clinical surveillance. Personalised pharmaceutical therapy and surgical interventions will help to optimise the treatment outcomes in patients suffering from these myopic macular diseases.
A microbiome‐targeting fibre‐enriched nutritional formula is well tolerated and improves quality of life and haemoglobin A1c in type 2 diabetes: A double‐blind, randomized, placebo‐controlled trial
Authors: Frias Juan P. , Lee Martin L. , Carter Matthew M. , Ebel Emily R. , Lai Ren‐Hau , Rikse Lars , Washington Marc E. , Sonnenburg Justin L. , Damman Christopher J. 
Published: January 2023

AbstractAimsTo investigate a prebiotic fibre‐enriched nutritional formula on health‐related quality of life and metabolic control in type 2 diabetes.Materials and MethodsThis was a 12‐week, double‐blind, placebo‐controlled study with an unblinded dietary advice only comparator arm. Participants were randomized 2:1:1 to a prebiotic fibre‐enriched nutritional formula (Active), a placebo fibre‐absent nutritional formula (Placebo), or non‐blinded dietary advice alone (Diet). Primary endpoint was change in core Type 2 Diabetes Distress Assessment System (cT2‐DDAS) at week 12. Glycated haemoglobin (HbA1c) change was a key secondary endpoint.ResultsIn total, 192 participants were randomized. Mean age was 54.3 years, HbA1c 7.8%, and body mass index 35.9 kg/m2. At week 12, cT2‐DDAS reduced significantly in Active versus Placebo (−0.4, p = .03), and HbA1c was reduced significantly in Active vs Placebo (−0.64%, p = .01). Gut microbiome sequencing revealed that the relative abundance of two species of butyrate‐producing bacteria (Roseburia faecis and Anaerostipes hadrus) increased significantly in Active vs. Placebo.ConclusionsA microbiome‐targeting nutritional formula significantly improved cT2‐DDAS and HbA1c, suggesting the potential for prebiotic fibre as a complement to lifestyle and/or pharmaceutical interventions for managing type 2 diabetes.
Reducing urban sprawl by optimizing housing production
Authors: Boukari Wadjidou , Long Fenjie 
Published: January 2023

AbstractScholars demonstrated the importance of house planners in the creation of environmentally friendly homes. Despite the lack of broad agreement on the type of freehold estate that could reduce urban sprawl, the authors agree on the role of government and developers in housing planning and construction. According to a recent study, the government and developers are investing in freehold estates to promote sustainable urban growth. However, this study employs urban growth theories to explain the policy's success. First, we examine the rate of urban growth and the trends in urban sprawl. The affordability of ground‐floor and three‐story buildings is then assessed. The findings show that 19.36 square kilometers of built‐up area contributed to land use expansion in Abomey‐Calavi, Benin Republic, between 1974 and 2015, and four districts are at higher risk of environmental degradation. To mitigate this, three‐story buildings could be inclusive and improve efficient land use, thereby limiting urban sprawl.
BARGAINING OVER TAXES AND ENTITLEMENTS IN THE ERA OF UNEQUAL GROWTH
Authors: Azzimonti Marina , Karpuska Laura , Mihalache Gabriel 
Published: January 2023

AbstractEntitlements have become an increasing component of total government spending in the United States over the last six decades. Using a political‐economy model where parties bargain over taxes and entitlements, we argue that such dynamics can be explained by two factors: “unequal growth,” where top earners became richer while the income of the bottom 50% stagnated, and budget rules that provide bargaining power to low‐income earners through a “status quo effect.” In a model calibrated to the United States, we show that sustained bargaining power by a party representing the poor results in a rising share of entitlements consistent with the data.
Unravelling the effect of phenolic compounds in the design of a yeast protein‐based emulsions
Authors: Ribeiro Ana Catarina , Simões Sara , Perez‐Gregorio Rosa , Soares Susana , Figueira Diogo , Branco Diogo Castelo , Tasso Ana , Raymundo Anabela , Mateus Nuno , Freitas Victor 
Published: January 2023

SummaryMayonnaise is an oil in water emulsion of egg, oil and an acid, worldwide consumed. The major challenges of the mayonnaise industry include searching for an alternative protein source. This study evaluates an alternative protein source, yeast protein extract (YPE), to replace egg in the mayonnaise model. Furthermore, the natural ability of phenolic compounds (PCs) to bind to proteins was studied to enhance the emulsifying capacity of YPE. The mayonnaise‐like emulsions were characterised according to their rheology, texture and colour profile. There were no differences in rheological parameters between the YPE emulsion (G' at 1 Hz 785 ± 15 Pa) and onion powder emulsion (G' at 1 Hz 785 ± 15 Pa) compared with the commercial mayonnaise (CC, G' at 1 Hz 747 ± 16 Pa). In general, the emulsions obtained with YPE and YPE‐PCs were found to have similar viscoelastic and viscosity properties to the CC. In terms of texture profile (firmness) the blueberry powder (0.574 ± 0.036 N), grape seed extract (0.497 ± 0.061 N) or wine extract (0.626 ± 0.128 N) YPE emulsions were equal to CC (0.561 ± 0.031 N). As a result, some of the mayonnaise‐like emulsions developed could be alternatives to CC regarding physical–chemical properties.
Stability of whey protein bioactive peptide‐stabilised nanoemulsions: effect of pH, ions, heating and freeze–thawing
Authors: Adjonu Randy , Doran Gregory , Torley Peter , Agboola Samson 
Published: January 2023

SummaryWhey protein hydrolysates are important food emulsifiers and bioactive ingredients. This study investigated the stability of whey protein isolate (WPI) bioactive peptide fraction nanoemulsions under representative food processing and storage conditions: pH (3–9), ion concentration (Na+, 0–200 mm and Ca2+, 0–15 mm), thermal treatment (30–90 °C) and freeze–thawing. Bioactive peptide fractions, UC–10 and UP–10, were obtained by ultrafiltration of chymotrypsin or pepsin WPI hydrolysates, respectively. The nanoemulsions produced with these fractions had droplet diameters of 177 ± 3.5 nm (UC–10) and 154 ± 1.6 nm (UP–10). Nanoemulsions destabilised at pH 3–5, around the isoelectric point of WPI proteins but were stable at higher pH values, 6–9. Nanoemulsion instability escalated above critical Na+ (25 mm) and Ca2+ (2.5 mm) concentrations, but Ca2+ accelerated droplet aggregation more strongly than Na+. Furthermore, nanoemulsions were moderately stable to heating and freeze–thawing. Overall, both WPI bioactive peptide‐stabilised nanoemulsions showed consistent stability to the processing conditions. This study expands on designing, producing and utilising nanoemulsions based on WPI bioactive peptides.
Extracting decision models for ski injury prediction from data
Authors: Radovanović Sandro , Bohanec Marko , Delibašić Boris 
Published: January 2023

AbstractCreating decision models for risk assessment of ski injuries is a challenging task. Ski injuries are rare events, but they carry a high cost, that is, can cause working or movement disabilities. Usually, ski risk assessment is performed on small‐scale, case‐controlled studies where the effect of a single factor is evaluated. Recently, data mining and machine learning algorithms are being employed for ski risk assessment and injury prediction. However, these models do not generally satisfy the need for interpretation of the decision model, do not provide explanations for the predictions, and in general do not ensure the completeness and consistency of decision rules. To make data mining and machine learning models useful, one needs to implement the aforementioned properties. Decision support systems are expected to have these properties; however, the process of building such decision support systems is still tedious: it has to consider human biases, assumptions, and subjective values, as well as focus on the decision problem being solved. We propose a method for extraction of decision models from data at hand. Our method DIDEX, Data Induced DEcision eXpert, builds models that have desirable properties for inclusion in decision support systems. The proposed method is used to build a decision model for ski injury prediction based on data from Mt. Kopaonik ski resort, Serbia. The results show that DIDEX generates up to a five times simpler model compared to the existing domain expert DEX models while having a 6% better predictive accuracy. Additionally, its predictive accuracy is comparable to similar machine learning algorithms, such as decision tree classifiers, random forest, and logistic regression.
Effect of solar drying on physical, chemical, and sensory properties of Cymbopogon citratus grown in Antioquia ‐ Colombia
Authors: Ocampo Arango Carlos Mario , Cañas Ángel Zoraida , Carazzone Chiara , Largo Ávila Esteban , Martínez Álvarez Olga Lucia , Mutis González Juan Sebastián 
Published: January 2023

AbstractThis study aimed to evaluate the effect of solar drying on the physical, chemical, and sensory properties of lemongrass grown in Antioquia, Colombia. Two single‐factor experimental designs were used. The first one, evaluated the drying method: dryer with solar collector and ventilation cycle programmer (D2), African Drying Bed (ADB), and Traditional Drying (TD); with load of 7 kg/m2. The second experimental design evaluated different loads (7 kg/m2 and 10 kg/m2) in dryers D2 and D1. The following analysis were performed: drying time, moisture content, color, volatile compounds, and sensory. Drying times were 26.3 h for D2 and 30.2 h for D1. The drying time was higher in ADB and TD. There were no significant differences in a* for the samples D2 (−2.23) and D1 (−1.41), which had a lower loss of green color, indicating a lesser degradation of chlorophyll against ADB and TD. Geranial and neral were found in a higher amount, isogeranial and β‐myrcene were also identified. D2 and D1 presented a higher aromatic intensity with overall quality of 7.1 and 6.9, respectively (0–10 scale). With the use of the dryers inside the greenhouse, drying times were reduced, generating a product with better characteristics in color and sensory attributes.Practical applicationsAlmost all the seasoning and infusion industries in Colombia import the spices used as raw material in their products, even though with inferior quality from the sensory point of view, however, complying with other commercial criteria. The cost of dehydrated lemongrass imported in Colombia is higher when compared to other imported spices. Lemongrass grown in Antioquia, Colombia, presents some drawbacks in its postharvest processes, which makes its commercialization difficult at the national and international level. The results from this research show that using dryers with solar collector, fan, and ventilation cycle control; located inside the greenhouse solar dryer; it is possible to better control the drying process, obtaining competitive products at the industrial level, which could economically help producing families. Moreover, the times for drying are decreased and a product that meets the quality standards required by the industry in generated, overcoming those obtained from the traditional drying methods currently used.
Design and development of laboratory scale batch type device for debittering of bitter citrus juice
Authors: Gupta Arun Kumar , Rather Muzamil Ahmad , Mishra Poonam 
Published: January 2023

AbstractDebittering of citrus juice has long been a stumbling challenge for the juice processing industries. The current debittering technique employs the adsorption of bitter compounds, which is reported to reduce a significant amount of vital nutrients, resulting in considerably lower antioxidant activity. Thus, in the present study, we are reporting a batch‐type laboratory‐scale debittering device using an interdigitated electrode (IDE), macroporous resin, and enzyme. Three different types of devices were developed. The first device was developed by adsorbing naringinase onto a macroporous resin and then being deposited on an IDE patterned printed circuit board (PCB) substrate. The second device was fabricated by the deposition of activated resin on IDE (an AR‐based device), while the third device was developed by depositing nonactivated resin on IDE (a NAR‐based device). The performance of the devices was evaluated by debittering the pomelo juice. It was observed that the device efficiently debitter 70–100 ml of juice in a batch manner. The juice was treated for 160 min at 60°C to determine the optimum time for a minimum level of naringin with the maximum retention of vital nutrients. A decreased level of naringin (53.06%) and increased naringenin content (16.19 ppm) were noticed with an increased time of exposure. Juice treated for 100 min had a significantly lower amount of naringin (39%), with maximum retention of vital nutrients. Contrary to this, juice treated with AR and NAR debittering devices reduced 32 and 19.65% of the naringin in 5 min with a maximum loss of bioactive compounds. The present study concludes that the fabricated debittering device reduced the bitterness up to a certain level with the minimum loss of other vital nutrients. Further study is needed to increase the handling capacity of juice and to study the storage stability of treated juice.Practical ApplicationBitterness has long been a stumbling barrier to the commercial acceptance of citrus juice. There are limited studies that can monitor the elimination of bitter components from citrus juices. The current attempt investigates the development of a debittering device that can easily monitor the level of bitterness during the debittering process of bitter citrus fruit. The easy fabrication process, reusability of the proposed device, and cost factor could be an alternative way to boost the commerciality of underutilized citrus fruits. The developed technology has a strong potential to scale up, as the cost is minimal and the design of the setup is very simple.
High cost of waste treatment calls for systematic rethinking: A case study for a chemical industrial park in China
Authors: Lyu Yizheng , Yan Kun , Tian Jinping , Chen Lyujun 
Published: January 2023

AbstractThe chemical industry has witnessed a heavy global environmental clean‐up and remediation burden. Chemical industrial parks (CIPs) are important carriers of the chemical industry and present both opportunities and challenges in terms of environmental sustainability. The end‐of‐pipe waste treatment system, comprised of enterprise facilities and shareable infrastructure, is mandatory in Chinese CIPs; in that sense, its cost is often taken for granted without accurate calculation, and reduction opportunities are commonly missed. Quantifying the whole‐process cost is thus crucial for promoting the waste treatment system of CIPs. This study established a bottom‐up and trilayer nested model for waste treatment, which integrated interphase material flows, pollutant reduction technology, and whole‐process cost accounting by targeting CIPs. The cost included wastewater treatment, waste gas treatment, and solid waste disposal costs, and each component further included depreciation, operation, and other expenditures. After empirically applying the model to a typical CIP in China, we revealed that this CIP attained a total waste treatment cost of 1.31 billion CNY (0.19 billion US dollars) in 2016, which is approximately 52.4% of the park's tax income. Overall, approximately 55.6% of the cost was attributable to wastewater treatment (729 million CNY, 108 million US dollars), 12.5% to waste gas treatment, and 31.9% to solid waste disposal. In the empirical case study, the cost imposed a substantial economic burden on the industrial park, while the environmental performance of the waste treatment system still required improvement. The results called for systematic rethinking which is featured by an extended system boundary and three dialectical relations in CIPs. Three policy recommendations were proposed by systematic rethinking, including symbiotic solutions targeting waste treatment infrastructures within and among enterprises, priority optimization on the key enterprises with high pollution emissionsand treatment costs, and flexible deployment of in‐plant waste treatment facilities.
Sardines at a junction: Seascape genomics reveals ecological and oceanographic drivers of variation in the NW Mediterranean Sea
Authors: Antoniou Aglaia , Manousaki Tereza , Ramírez Francisco , Cariani Alessia , Cannas Rita , Kasapidis Panagiotis , Magoulas Antonios , Albo‐Puigserver Marta , Lloret‐Lloret Elena , Bellido Jose Maria , Pennino Maria Grazia , Follesa Maria Cristina , Esteban Antonio , Saraux Claire , Sbrana Mario , Spedicato Maria Teresa , Coll Marta , Tsigenopoulos Costas S. 
Published: January 2023

AbstractBy evaluating genetic variation across the entire genome, one can address existing questions in a novel way while raising new ones. The latter includes how different local environments influence adaptive and neutral genomic variation within and among populations, providing insights into local adaptation of natural populations and their responses to global change. Here, under a seascape genomic approach, ddRAD data of 4609 single nucleotide polymorphisms (SNPs) from 398 sardines (Sardina pilchardus) collected in 11 Mediterranean and one Atlantic site were generated. These were used along with oceanographic and ecological information to detect signals of adaptive divergence with gene flow across environmental gradients. The studied sardines constitute two clusters (FST = 0.07), a pattern attributed to outlier loci, highlighting putative local adaptation. The trend in the number of days with sea surface temperature above 19°C, a critical threshold for successful sardine spawning, was crucial at all levels of population structuring with implications on the species' key biological processes. Outliers link candidate SNPs to the region's environmental heterogeneity. Our findings provide evidence for a dynamic equilibrium in which population structure is maintained by physical and ecological factors under the opposing influences of migration and selection. This dynamic in a natural system warrants continuous monitoring under a seascape genomic approach that might benefit from a temporal and more detailed spatial dimension. Our results may contribute to complementary studies aimed at providing deeper insights into the mechanistic processes underlying population structuring. Those are key to understanding and predicting future changes and responses of this highly exploited species in the face of climate change.