bluuebunny/crossref_metadata_2025_split huggingface dataset:
Temporal changes of patient characteristics over 12 years in a single-center transcatheter aortic valve implantation cohort
Authors: Demal Till Joscha , Weimann Jessica , Ojeda Francisco Miguel , Bhadra Oliver D. , Linder Matthias , Ludwig Sebastian , Grundmann David , Voigtländer Lisa , Waldschmidt Lara , Schirmer Johannes , Schofer Niklas , Blankenberg Stefan , Reichenspurner Hermann , Conradi Lenard , Seiffert Moritz , Schaefer Andreas 
Published: February 2023

Abstract
Background
Beneficial results of transcatheter aortic valve implantation (TAVI) compared to surgical aortic valve replacement (SAVR) in patients at all risk strata have led to substantial changes in guideline recommendations for valvular heart disease.

Aim
To examine influence of these guideline changes on a real-world TAVI cohort, we evaluated how risk profiles and outcomes of TAVI patients developed in our single-center patient cohort over a period of 12 years.

Methods
Baseline, procedural and 30-day outcome parameters of TAVI patients were retrospectively compared between three time periods (period 1: 2008–2012, period 2: 2013–2017, period 3: 2018–2020).

Results
Between 03/2008 and 12/2020, a total of 3678 patients underwent TAVI at our center. The median age was 81.1 years (25th, 75th percentile: 76.7, 84.9) with no significant change over time. The EuroSCORE II showed a continuous and significant decline from 5.3% (3.3, 8.6) in period 1 to 2.8% (1.7, 5.0) in period 3 (p < 0.001). Furthermore, rates of permanent pacemaker implantation, acute kidney injury, and paravalvular leakage ≥ moderate continuously declined over time. Accordingly, the 30-day mortality fell from 9.3% in period 1 to 4.3% in period 3 (p < 0.001).

Conclusion
Despite substantial guideline alterations, median patient age remained largely unchanged in our TAVI cohort over the past 12 years. Therefore, increased age still appears to be the main reason to choose TAVI over SAVR. However, risk profiles declined substantially. Significant improvements in early outcomes suggest favorable influence of less invasive access routes, improved device platforms and growing user experience.

Graphical abstract
Comparison of the LigaSure™ bipolar vessel sealer to monopolar electrocoagulation for thoracoscopic lobectomy and lymphadenectomy: a prospective randomized controlled trial
Authors: Gabryel Piotr , Kasprzyk Mariusz , Roszak Magdalena , Campisi Alessio , Smoliński Szymon , Zieliński Paweł , Piwkowski Cezary 
Published: February 2023

Abstract
Background
High-energy devices allow better vessel sealing compared with monopolar electrocautery and could improve the outcomes of surgical operations. The objective of the study was to compare tissue dissection by the LigaSure™ device with that by monopolar electrocoagulation for thoracoscopic lobectomy and lymphadenectomy.

Methods
This pragmatic, parallel group, prospective randomized controlled trial was funded by the Medtronic External Research Program (ISR-2016–10,756) and registered at www.clinicaltrials.gov (NCT03125798). The study included patients aged 18 years or older, who had undergone thoracoscopic lobectomy with lymphadenectomy at the Department of Thoracic Surgery of Poznan University of Medical Sciences between May 3, 2018, and November 4, 2021. Using simple randomization, the patients were assigned to undergo tissue dissection with either the LigaSure device (study group) or monopolar electrocautery (control group). Participants and care givers, except operating surgeons, were blinded to group assignment. The primary outcome was postoperative chest drainage volume. Secondary outcomes were change of the esophageal temperature during subcarinal lymphadenectomy and C-reactive protein level 72 h after surgery.

Results
Study outcomes were analyzed in 107 patients in each group. We found no differences between the study and control groups in terms of chest drainage volume (550 vs. 600 mL, respectively; p = 0.315), changes in esophageal temperature (− 0.1 °C vs. − 0.1 °C, respectively; p = 0.784), and C-reactive protein levels (72.8 vs. 70.8 mg/L, respectively; p = 0.503). The mean numbers of lymph nodes removed were 12.9 (SD: 3.1; 95% CI, 12.4 to 13.5) in the study group and 11.6 (SD: 3.2; 95% CI, 11.0 to 12.2) in the control group (p < 0.001).

Conclusions
The use of the LigaSure device did not allow to decrease the chest drainage volume, local thermal spread, and systemic inflammatory response. The number of lymph nodes removed was higher in patients operated with the LigaSure device, which indicated better quality of lymphadenectomy.
A harmonic framework for stepsize selection in gradient methods
Authors: Ferrandi Giulia , Hochstenbach Michiel E. , Krejić Nataša 
Published: February 2023

AbstractWe study the use of inverse harmonic Rayleigh quotients with target for the stepsize selection in gradient methods for nonlinear unconstrained optimization problems. This not only provides an elegant and flexible framework to parametrize and reinterpret existing stepsize schemes, but it also gives inspiration for new flexible and tunable families of steplengths. In particular, we analyze and extend the adaptive Barzilai–Borwein method to a new family of stepsizes. While this family exploits negative values for the target, we also consider positive targets. We present a convergence analysis for quadratic problems extending results by Dai and Liao (IMA J Numer Anal 22(1):1–10, 2002), and carry out experiments outlining the potential of the approaches.
The Relationship between Youth Police Stops and Depression among Fathers
Authors: Turney Kristin 
Published: February 2023

AbstractResearch shows youth police contact—a stressor experienced by more than one-quarter of urban-born youth by age 15—has deleterious mental health consequences for both youth and their mothers. Less is known about how youth’s fathers respond to this police contact, despite differences in how men and women respond to stress and relate to their children. I use data from the Fragile Families and Child Wellbeing Study to investigate the association between youth police stops and depression among youth’s fathers. Results show that fathers of youth stopped by the police, compared to fathers of youth not stopped by the police, are more likely to report depression, net of father and youth characteristics associated with selection into experiencing youth police stops. This association is concentrated among non-Black fathers and fathers of girls. The findings highlight how the repercussions of youth criminal legal contact extend to youth’s fathers and, more broadly, suggest that future research incorporate the responses of men connected to those enduring criminal legal contact.
Impact and Compression-After-Impact Performance of a Thin Z-Pinned Composite Laminate
Authors: Francesconi L. , Loi G. , Aymerich F. 
Published: February 2023

AbstractImpact and compression-after-impact (CAI) tests were carried out on [02/ ± 45]s carbon/epoxy samples to characterize the effect of z-pinning on the delamination resistance and damage tolerance properties of the laminate. Unpinned and z-pinned samples were subjected to impacts between 2 and 36 J to produce damage conditions that extend from barely visible impact damage (BVID) to complete penetration. The damage induced by impact and the damage modes leading to ultimate CAI failure were examined by X-radiography and by direct observations of the sample faces during CAI loading. The analyses indicate that the role of z-pins on the impact and CAI response of the laminate is dependent on the size and features of the damage. Z-pins do not modify the structural response to impact of the laminate, but they are effective in reducing the extent of damage for impact energies above a threshold value. Z-pinning is also effective in improving the CAI strength of the laminate for impact energies above this threshold value, even though it degrades the residual compressive strength for lower impact energies. Reductions in impact delamination size of up to 50% and improvements in CAI strength of about 20% were achieved by z-pinning for high-energy impacts. The mechanisms by which the z-pins affect the CAI response of the samples are illustrated and examined in detail for different impact damage severities.
Mitigation of Imidacloprid Toxicity in Poultry Chicken by Selenium Nanoparticles: Growth Performance, Lipid Peroxidation, and Blood Traits
Authors: Eid Yahya Z. , Omara Yassin , Ragab Asmaa , Ismail Ahmed , Zommara Mohsen , Dawood Mahmoud A. O. 
Published: February 2023

Abstract
Imidacloprid is an insecticide that protects against insects in the agriculture, animal, and poultry production sectors. Since the accumulation of imidacloprid induces adverse impacts on general health status and quality of the food chain, this study tested the impacts on broilers. Besides, selenium nanoparticles were fed to birds to relieve the negative impacts on growth performance and health status. Birds (1-day age, initial weight 46.05 ± 1.0 g) divided into four groups (triplicates) where 15 chicks of each replicate (45 for each group). The first group (control) was fed the basal diet without either selenium or imidacloprid toxicity. The second group was fed selenium nano form at 3 mg/kg. The third group was fed selenium and exposed to imidacloprid at 1/10 LT50 (3 mg/kg body weight). The fourth group was fed selenium nano form (3 mg/kg) and exposed to imidacloprid at 1/10 LT50 (3 mg/kg body weight). All groups were kept under the same conditions for 35 days. The final weight and weight gain of birds fed selenium nano form showed marked improvement compared to the imidacloprid-exposed group, while the feed intake and feed conversion ratio markedly reduced. The red blood cells showed higher values in birds fed selenium nano than the control and those exposed to imidacloprid. Interestingly, the hemoglobulin and hematocrit increased in birds fed selenium nano form with or without imidacloprid exposure. Furthermore, the white blood cells increased in birds fed selenium nano form with or without imidacloprid exposure. The total protein, albumin, and globulin were higher in birds fed selenium nanoparticles than those exposed to imidacloprid with or without selenium feeding. Birds in the control and imidacloprid groups had higher aspartate aminotransferase (AST), alanine aminotransferase (ALT), and malondialdehyde levels than the remaining groups. Accordingly, dietary selenium nanoparticles are suggested in broiler feed to cope with the adverse effects of imidacloprid toxicity.
Healthcare workers’ infection risk perceptions of aerosol-generating procedures and affective response
Authors: Benishek Lauren E. , Radonovich Lewis J. , Blackley Brie H. , Weissman David N. 
Published: February 2023

Abstract

Objective:
To understand healthcare worker (HCW) perceptions of infection risk associated with aerosol-generating procedures (AGPs) and their affective response to performing AGPs.

Design:
Systematic review.

Methods:
Systematic searches of PubMed, CINHAL Plus, and Scopus were conducted using combinations of selected keywords and synonyms. To reduce bias, titles and abstracts were screened for eligibility by 2 independent reviewers. Also, 2 independent reviewers extracted data from each eligible record. Discrepancies were discussed until consensus was reached.

Results:
In total, 16 reports from across the globe were included in this review. Findings suggest that AGPs are generally perceived to place HCWs at high risk of becoming infected with respiratory pathogens and that this perception stimulates a negative affective response and hesitancy to participate in the procedures.

Conclusions:
AGP risk perception are complex and context dependent but have important influences on HCW infection control practices, decision to participate in AGPs, emotional welfare, and workplace satisfaction. New and unfamiliar hazards paired with uncertainty lead to fear and anxiety about personal and others’ safety. These fears may create a psychological burden conducive to burnout. Empirical research is needed to thoroughly understand the interplay between HCW risk perceptions of distinct AGPs, their affective responses to conducting these procedures under various conditions, and their resulting decision to participate in these procedures. Results from such studies are essential for advancing clinical practice; they point to methods for mitigating provider distress and better recommendations for when and how to conduct AGPs.
Interdisciplinary Collaboration in International Crisis Medical Relief: A Look at the Nepal Earthquake and Ebola Relief Efforts
Authors: Penta Samantha 
Published: February 2023

Abstract

Objective:
This study explores interprofessional collaboration among medical and non-medical personnel planning and implementing international crisis health and medical relief efforts, and how disciplinary and professional background influences these activities.

Methods:
This study analyzes semi-structured interviews with individuals involved in organizations medical or health services to the Ebola epidemic in West Africa (2014-2016) or the 2015 Nepal earthquake.

Results:
Disciplinary background, sometimes coupled with organization role, shaped how relief workers engaged in the process of planning and implementing crisis medical relief. There were 3 thematic areas where these differences emerged: issue focus, problem -solving approaches, and decision-making approaches. Solutions from the field emerged as a fourth theme.

Conclusions:
The study demonstrates medical relief required collaboration across medical and non-medical professions and highlights the importance of relief workers’ disciplinary background in shaping the planning and implementation of crisis medical relief. Successful collaboration requires that people involved in crisis relief communicate the relevance of their own expertise, identify limits of their own and others’ disciplinary perspective(s), seek out strengths in others’ expertise, and can identify/ respond appropriately to others who do not see their own disciplinary limits, as well as learn these skills before engaging in relief.
Healthcare and Social Organizations’ Disaster Preparedness, Response, and Recovery Experience: Lessons Learned From Hurricanes Irma and Maria
Authors: Noboa-Ramos Carlamarie , Almodóvar-Díaz Yadira , Fernández-Repollet Emma , Joshipura Kaumudi 
Published: February 2023

Abstract

Background:
Healthcare and social organizations (HSOs) are first respondents after natural disasters. Hence, their preparedness and resilience are critical components for addressing future disasters. However, little is known about HSOs’ experiences prior to, during, and after hurricanes.

Objective:
To describe preparedness, response, and recovery experiences from hurricanes Irma/ Maria among HSOs in Puerto Rico and the US Virgin Islands.

Methods:
Using a convenience sample, semi-structured interviews were conducted with 52 key-informants. Content analysis for common and recurring themes and patterns was performed by HSO type.

Results:
Most HSOs (80.8%) had a preparedness plan and 55.8% responded providing emergency supplies. HSOs’ human resources (61.2%) was the main recovery facilitator/ enabler, while 36.5% identified the lack of economic resources and the lack of an integrated emergency plan as the top barriers. The main lesson learned include understanding the need to make improvements to their emergency preparedness plans (56.3%), and to establish an integrated/ centralized plan between relevant parties.

Conclusion:
Lessons learned after hurricanes allowed HSOs to identify gaps and opportunities to become more resilient. Infrastructure capacity, human resources, communication systems, and economic support, as well as training, partnerships, and new policies should be defined, revised, and/ or integrated into the HSOs’ preparedness plans to mitigate the impact of future disasters.
Legal dispositionism and artificially-intelligent attributions
Authors: Soh Jerrold 
Published: February 2023

AbstractIt is conventionally argued that because an artificially-intelligent (AI) system acts autonomously, its makers cannot easily be held liable should the system's actions harm. Since the system cannot be liable on its own account either, existing laws expose victims to accountability gaps and need to be reformed. Recent legal instruments have nonetheless established obligations against AI developers and providers. Drawing on attribution theory, this paper examines how these seemingly opposing positions are shaped by the ways in which AI systems are conceptualised. Specifically, folk dispositionism underpins conventional legal discourse on AI liability, personality, publications, and inventions and leads us towards problematic legal outcomes. Examining the technology and terminology driving contemporary AI systems, the paper contends that AI systems are better conceptualised instead as situational characters whose actions remain constrained by their programming. Properly viewing AI systems as such illuminates how existing legal doctrines could be sensibly applied to AI and reinforces emerging calls for placing greater scrutiny on the broader AI ecosystem.
Abandoning individual enforcement? Interrogating the enforcement of age discrimination law
Authors: Blackham Alysia 
Published: February 2023

AbstractDiscrimination law primarily relies on individual enforcement for addressing discrimination at work; yet those who are most impacted by discrimination are likely the least able to enforce their rights. The question then becomes: what role should individual enforcement play in discrimination law? Can we effectively abandon individual enforcement as part of the legislative model? Drawing on a mixed method, multi-year comparative study of the enforcement of age discrimination law in the UK, Australia and Sweden, this paper considers the gaps, limits and risks of the individual enforcement model in discrimination law. Integrating doctrinal analysis; statistical analysis of claims and cases, and data from the EU and OECD; qualitative expert interviews; and a survey of legal practitioners, this paper argues that while individual enforcement is inherently limited as a tool for achieving systemic change, it must remain part of any legislative model. Reflecting on the experience in Sweden, where individual enforcement of discrimination law is significantly curtailed, the paper posits that individual rights and individual enforcement remain important complements to other regulatory tools, particularly in jurisdictions with strong enduring age norms. Abandoning or severely restricting individual enforcement is unlikely to support either the macro or micro effectiveness of age discrimination law.
Microbiota signatures and mucosal healing in the use of enteral nutrition therapy v. corticosteroids for the treatment of children with Crohn’s disease: a systematic review and meta-analysis
Authors: Ding Zhaolu , Ninan Kiran , Johnston Bradley C. , Moayyedi Paul , Sherlock Mary , Zachos Mary 
Published: February 2023

AbstractCorticosteroids (CS) and exclusive and partial enteral nutrition (EEN and PEN) are effective therapies in paediatric Crohn’s disease (CD). This systematic review of randomised controlled trials (RCT) and cohort studies analyses the impact of EEN/PEN v. CS on intestinal microbiota, mucosal healing as well as other clinically important outcomes, including clinical remission, relapse, adherence, adverse events and health-related quality of life (HRQL) in paediatric CD. Three RCT (n 76) and sixteen cohort studies (n 1104) compared EEN v. CS. With limited available data (one RCT), the effect on intestinal microbiome indicated a trend towards EEN regarding Shannon diversity. Based on two RCT, EEN achieved higher mucosal healing than CS (risk ratio (RR) 2·36, 95 % CI (1·22, 4·57), low certainty). Compared with CS, patients on EEN were less likely to experience adverse events based on two RCT (RR 0·32, 95 % CI (0·13, 0·80), low certainty). For HRQL, there was a trend in favour of CS based on data from two published abstracts of cohort studies. Based on thirteen cohort studies, EEN achieved higher clinical remission than CS (RR 1·18, 95 % CI (1·02, 1·38), very low certainty). Studies also reported no important differences in relapse and adherence. Compared with CS, EEN may improve mucosal healing with fewer adverse events based on RCT data. While limited data indicate the need for further trials, this is the first systematic review to comprehensively summarise the data on intestinal microbiome, mucosal healing and HRQOL when comparing enteral nutrition and CS in paediatric CD.
Mass Pilgrimage and the Usable Empire in a Napoleonic Borderland
Authors: Harrer Kilian 
Published: February 2023

AbstractThis article analyses the biggest pilgrimage event of the Napoleonic era, showing how Catholics used imperial opportunities and imperial loopholes to progress on their path toward religious revival. In September 1810, more than 200,000 pilgrims rushed to the small provincial city of Trier to venerate one of Christianity's most important relics, the Holy Coat of Jesus. This pilgrimage could take place and grow to such gigantic dimensions because both clerical elites and laypeople deftly navigated territorial frameworks created by the Napoleonic state. In the Rhenish borderlands to which Trier belonged, French hegemony enabled the return of the relic to the city in the first place, but pilgrims subsequently exploited the malleability of public order that also characterized imperial governance. The great pilgrimage of 1810 represented neither a form of exclusively top-down mobilization orchestrated by the church and controlled by the state, nor an act of overt, politicized opposition – even as state officials, in turn, proved undeniably hostile to pilgrim mobility and ‘superstition’. The article therefore argues that, in the more peaceful parts of Napoleon's empire, pilgrims and pilgrimage organizers accelerated post-revolutionary Catholic renewal by using that empire rather than either resisting or collaborating with it.
Analysis of deprescription strategies of proton pump inhibitors in primary care: a narrative review
Authors: Del-Pino Miguel , Sanz Emilio J. 
Published: February 2023

Abstract

Background:
Since the introduction of omeprazole in 1989, proton pump inhibitors (PPIs) have become the mainstream of treatment for acid-related pathologies, but nowadays, it is estimated that between 20% and 80% of people worldwide who are using PPIs are doing so without an approved indication. Overusing PPIs is known to involve a tremendous cost in financial terms, and many western countries have reported high spending on these medicines.

Objective:
We conducted a narrative review to evaluate PPI deprescription strategies carried out entirely or in collaboration with primary care and to identify factors that could influence the success of these strategies.

Method:
This review was conducted in November 2022, following PRISMA guidelines. Four databases were searched: PubMed, Web of Science, Scopus and CINAHL Complete, using the MeSH terms ‘proton pump inhibitors’ AND ‘deprescriptions’.

Results:
The search with the established criteria found eight studies. The different success rates obtained by the various studies analysed in this review may be due to the different methodologies used when establishing the protocols, sample selection and monitoring of the results.

Conclusion:
We can conclude that the two factors related to the most successful strategies were a) the clarity and simplicity of the de-escalation protocols, in which patients were instructed on the measures to follow in the event of the reappearance of symptoms, and b) the training of the physicians responsible for deprescribing. Long-term conclusions cannot be drawn about the effectiveness of these protocols, given that the studies are limited in time. Other barriers to generalizing the results are the small sample size and the absence of control groups.