bluuebunny/crossref_metadata_2025_split huggingface dataset:
Changes in Day 4 and day 0 Neutrophil-lymphocytes ratio in predicting single-dose methotrexate treatment failure for ectopic pregnancies
Authors: Abuduxukuer Rukeyemu , Chen Xiaoyue , Jingyi N , Liu Na , Cai Bailian , Shen Yuting , Li Shuangdi , Li Zhen , Lu Wen 
Published: January 2023

Abstract
Purpose
We aimed to evaluate changes in neutrophil/lymphocyte ratio between the day 4 and day 0 of ectopic pregnancy (EP) patients treated with single-dose methotrexate (MTX). And to further investigate whether the NLR change is an indicator for MTX treatment outcome.
Methods
Totally 406 patients underwent single-dose MTX therapy for EP at Shanghai First Maternity and Infant Hospital from 2013/01/10 to 2019/09/30 were studied. A multivariate model was structured to predict the treatment outcome.
Results
Finally, 281 patients were in the successful treatment group, and their NLR at day 4 dropped 25% when compared with day 0. The success rate was significantly declined when the NLR decreased less than 23% (74.8% vs 58.5%, p = 0.004). Multivariate regression analysis revealed that day 4/day 0 NLR reduced less than 23% (OR:2.09, 95%CI:[1.27–3.44]); hCG decreased no more than 15% (OR:3.17,95% CI: [1.62–6.34] and increased over 15% on day 4 (OR:5.47, 95% CI: [3.05–10.22]) were independent risk factors for single-dose MTX treatment failure. Our final predictive model had a sensitivity of 0.768 and specificity of 0.569 when we chose 3 as the cut-off value. The area under the receiver operating characteristic curve was 0.712. Patients with a predictive score of ≥ 3 are more likely to fail in a single-dose MTX therapy.
Conclusion
In this study, we concluded that NLR decreased less than 23% on day 4 compared with day 0, a plateau or increased serum hCG on day 4 and hCG value over1000 mIU/ml at day 0 were predictors of single-dose MTX treatment failure.
Tumor recurrence after pathologic complete response in locally advanced gastric cancer after neoadjuvant therapy: case report and literature review
Authors: Xing Yu , Zhang Zi-Li , Ding Zhi-Ying , Song Wei-Liang , Li Tong 
Published: January 2023

Abstract

Most patients with gastric cancer are advanced at the time of diagnosis. Therefore, in order to improve the R0 resection rate, increase the PCR rate, and reduce the recurrence rate, different regimens have been tried to improve the perioperative treatment of advanced local gastric cancer. In recent years, immunotherapy has revolutionized cancer treatment. PD-1 and PD-L1 inhibitors have shown excellent efficacy in various tumors and have become potential therapeutic approaches after surgery, chemotherapy, radiotherapy, and targeted therapy. MSI-H/dMMR is a recognized marker for predicting the efficacy of immunotherapy for gastric cancer, and MSI-H/dMMR patients are more suitable for immunotherapy. However, the efficacy of immunotherapy alone in the treatment of gastric cancer is still unsatisfactory. We explore that combined immunosuppressive therapy may be valuable in improving the PCR rate of patients. Here, we report two female patients with gastric cancer defined as clinical stage (CT4N1-2M0), the detection of mismatch repair protein showed: dMMR (equivalent to MSI-H); PD-1 inhibitor combined with SOX (S-1 + oxaliplatin) in perioperative treatment obtained pCR, suggesting that PD-1 inhibitor combined with chemotherapy provides a more strategic choice for comprehensive perioperative treatment of gastric cancer. It is controversial for PCR patients to continue comprehensive chemotherapy or clinical observation after surgery. Surprisingly, two patients underwent clinical observation after surgery but developed different degrees of metastasis at about six months after surgery. Therefore, we reviewed the comprehensive perioperative treatment of two patients, hoping to provide some reference value for clinical decision-making.
Intraoperative transthoracic ultrasound in the differential diagnosis of small hepatectomy-induced pneumothorax
Authors: Li Jun , Huang Zeyong , Yao Weixian , Lv Mingfeng , Huang Suqin , Li Yuhong , Hu Zhiyong 
Published: January 2023

Abstract
Transthoracic ultrasound is widely used in to diagnose and treat lung diseases, such as pneumonia, atelectasis, pneumothorax and pulmonary edema. Recently, intraoperative transthoracic ultrasound was used to promptly identify two cases of early pneumothorax in patients that underwent liver surgery. We documented the process of pneumothorax occurrence and the patient outcomes. Timely discovery and effective real-time monitoring and evaluation of the scope of pneumothorax ensured the smooth completion of the operation and successfully avoided closed thoracic drainage in one case, avoiding further patient trauma. Indeed, intraoperative ultrasound is an effective approach to diagnose and evaluate pneumothorax that does not affect the progress of surgery and is more convenient and sensitive than conventional chest radiography.
Study and evaluating urban sprawl with future prediction (CA Markov model), using Gis and remote sensing
Authors: amine arab nabil 
Published: January 2023

Abstract
The objective of our study is to evaluate the phenomenon of urbanization in the wilaya of Tizi-Ouzou through two distinct methods, the first method is to generate a map of extraction of builtup areas (BAEMOLI) from the calculation of the index of normalized difference of the builtup NDBI OLI, the index of vegetation NDVI OLI and the modified index of normalized difference of the water MNDWI OLI, and the second method is to use the supervised classification has different period 2009 , 2015 and 2021, we start with the first method in order to have a visual overview of the urban growth in the different regions of the wilaya of Tizi-Ouzou, and in knowledge of the limitations of the first method which certainly allows to have an approximate and global overview of the phenomenon to study something which is primordial to have a methodical approach of the phenomenon which rages in the wilaya and these regions, but which unfortunately does not make it possible to make the distinction between the bare grounds and the urban zones, thing which pushed us has used a second complementary method, that of the supervised classification in order to add a more detailed study by quantifying this urbanization, with figures and statistics which make it possible to analyze the phenomenon of urbanization with much more precision In addition to establishing a future projection using the Cellular Automata Markov model, and end up with explanations and interpretations of urban sprawl in six regions of the wilaya of Tizi-Ouzou
Investigation of Hydrological and Hydrogeological Parameters’ Alterations in Rapidly Urbanized Regions: Bornova Case (İZmi̇R, Türki̇Ye)
Authors: ÖZTÜRK BAHADIR , UZELLİ TAYGUN , İŞBUĞA VOLKAN , BABA ALPER 
Published: January 2023

Abstract
One of the most important factors affecting the utilization of land and water is urbanization. Understanding urbanization and its effects on ground systems became more important as the world's population increased and climate changed. The Bornova Region, located in İzmir, Türkiye, which was once used as farmland, is the subject of this study. After the settlement started to happen, excessive urbanization reduced the plain's surface area's permeability as a result of the built-in structures, paved roads, and other surface coverings. GIS-based hydrological models were used to examine the effects of land-use and land cover changes on the Bornova Plain's aquifers over two distinct periods (2004 and 2020). These scenarios were created with ArcSWAT for this work. Using SWAT models, components of the water budget equation were established. The SWAT Models demonstrated that, between 2004 and 2020, the ratios of recharge to precipitation, streamflow to precipitation, and baseflow to total flow decreased by 52%, 26.09%, and 11.86%, respectively, while the ratios of surface runoff to total flow and evapotranspiration to precipitation increased by 20.59% and 15.09%, respectively.
The 100 most-cited publications on Peyronie’s disease: A bibliometric analysis and visualization study
Authors: Chang Degui , Gao Dawei , Shen Yifeng , Tang Bo , Ma Ziyang , Chen Diang , Li Guangsen 
Published: January 2023

AbstractBackground:Over the past few decades, there has been a substantial increase in our understanding of Peyronie's disease (PD), improving our ability to diagnose and treat the disorder clinically. The goal of this study is to disclose the development trend of the PD field and provide resources for academics. It does this by providing the 100 most-cited publications in the field and conducting bibliometrics and visualization analysis on them.Methods:The SCI-E of WoSCC provided us with the top 100 most-cited publications in PD research, from which we took the following information: year of publication, annual citations, nation/region, institution, journal, author, and keywords. VOSviewer (version 1.6.18) was used for visual analysis to evaluate the keywords.Results:Through a standardized search, we ultimately found 1,019 papers in the field of PD research, from which we extracted the 100 works that had received the highest citations. The articles published between 1949 and 2016 have been cited between 73 and 338 times. The United States is a major contributor to PD research. The University of California, Los Angeles, is the institution with the largest number of articles. Levine LA, Lue TF, Gelbard MK and others are among the most authoritative authors in the field. Sixteen journals published the top 100 cited articles, with the Journal of Urology being the most influential in the field, with 47 publications. Erectile dysfunction (n=19) is the keyword with the highest frequency, indicating that PD-related erectile dysfunction is the leading focus of research in this field. Most of the keywords that have appeared in the past decade are related to the clinical treatment of PD. Therefore, we think the frontier of future research will be to maximize the improvement of male erectile function in the therapeutic therapy of PD.Conclusion:Our study uses bibliometrics and visualization analysis of the most important articles in the field of PD research to show the current state of research in this area, depict the history of research trends, and provide a forecast for the future growth of PD.
Transferability of Rice Yield and Seed Quality Gene Tagged Markers to Peanut (Arachis hypogaeaL.): A Way Ahead in Groundnut Improvement
Authors: Sukrutha B , Akkareddy Srividhya , Vemireddy LN , AR Nirmal Kumar 
Published: January 2023

Abstract

Background The progress in tagging/mapping of genes in crops likeArabidopsis, rice, maize etc. is far ahead when compared to the major legume cropsviz. groundnut, chickpea, redgram, greengram, soyabean etc., even in the post release period of legume genome sequence databases. This can be attributed mainly to low level of available molecular genetic diversity in these crops. Methods The study of transferability of Rice yield gene tagged markers to Peanut was carried out by employing17 diverse groundnut genotypes. ANOVA revealed significant differences for six yield and seven seed quality traits studied which indicates availability of ample amount of variability among the genotypes. Molecular analysis was conducted to analyse the transferability of known rice yield, grain size and micronutrient content (Fe and Zn) controlling gene tagged markers (GTMs) to peanut by using 45 GTMsthat targets 24 known functional genes. Results Of 45 markers, 31 (76%) were transferable to peanut, denotes very high conservation at functional regions. The extent of amplification of rice GTMs at individual groundnut genotype level was observed from 79.17% for the cultivated varieties (2n = 4x) Nithya Haritha, Greeshma, Prasuna, Kalahasti, Narayani and with a wild genotype,Arachis villosa(2n = 2x) to 91.67% for Dheeraj variety. The analysis on transferable efficiency of individual rice GTM revealed that 17 markers belong to 14 rice genes showed amplification among all the 17groundnut genotypes (100%) under study. Conclusions Hence, focusing research on the available knowledge of functionally characterized genes of molecular model crops and vast list of annotated orthologous genes present in ‘Omics’ databases, widens the scope to tag the genes at molecular level and thereby to improve the cropslike groundnutthat has meager progress in gene tagging;by pyramiding of desirable genes with high veracity.
Imaging in pediatric presacral tumors with intraspinal extension: Lessons from a series of six cases
Authors: A Ebinesh , Prakash Anjali , Ashta Aanchal , Garg Anju , Verma Abhishek , Padaliya Prerna 
Published: January 2023

Abstract
Presacral space is a potential space between the rectum anteriorly and lumbosacral spine posteriorly containing derivatives from various primitive germ cell types which serve as origin to a myriad of tumors. Imaging plays a vital role in diagnosis, characterization, assessing extent and evaluation of spread. We present a series of six cases of pediatric presacral tumors with intraspinal extension. The series comprises of an immature sacrococcygeal teratoma (Altman type II), a malignant sacrococcygeal teratoma (Altman type IV), a neuroblastoma, a rhabdomyosarcoma, a clear cell sarcoma and an Ewing’s sarcoma of the ilium which can be broadly categorized as tumors of germ cell, neuroblastic, mesenchymal, osteogenic origin. In spite of overlapping imaging features, careful retrospective observation revealed few distinctive features that would aid in optimal characterization of tumors with a fair degree of certainty.In summary, the salient imaging features that aid in differentiation are the epicentre of the tumor, pattern and degree of bone involvement, status of sacral foramina and neural elements and internal characteristics such as presence of fat, calcification, hemorrhage, necrosis, etc.
Pattern and Outcome of Patients Admitted to the Intensive Care Unit of Addis Ababa Burn Emergency and Trauma Hospital
Authors: Mamo Dirijit , Aklog Etsegenet , Gebremedhin Yemane 
Published: January 2023

Abstract

Background: Information on the patterns of admission, outcome, and associated factors of intensive care unit patients is critical for evaluating healthcare programs. However, this information is scarce in developing countries. Analyzing the pattern of intensive care unit admission helps officials develop better strategies for improved resource allocation, resulting in an overall reduction of poor outcomes.
Objectives: This study aimed to assess patterns of admission, outcome, and associated factors among patients admitted to the intensive care unit in Addis Ababa hospital from 2017 to 2019.
Methodology: A two-year retrospective study of 268 admitted patients was done. A Systematic random sampling technique was employed to get the required samples from the database. Data was collected using a structured questionnaire. Data was entered into Epi-info version 3.5.3 and exported to SPSS Version 24 for analysis. Bivariate and multivariate logistic regression were used to analyze the association between dependent and independent variables and P-value <0.05 at 95% CI was declared as statistically significant.
Results: Out of 268 charts reviewed, 193 (73.5%) were male and 75 (26.5%) were females. The mean age of the patients was 32.6 years. The most common reasons for admission were trauma 163(53.4%), followed by medical 66(24.6%). Moreover, traumatic brain injury accounts 146(82.5%) of trauma cases, followed by limb injury 40(14.9%). Regarding their outcome 94(35.1%) of patients transferred to their respective wards, and 91(34.1%) were discharged. The overall mortality was 58(21.6%). In Bivariate analyses, Glasgow coma score, admission category, pre-referral care, and age were significantly associated with death. In multivariate analysis, Glasgow coma score 3-8, admission category, and pre-referral care were factors associated with increased risk of death.
Conclusion: The majority of admissions were Trauma-related. Road traffic accidents were the major cause of injury (3.5%), and traumatic brain injuries constituted the highest percentage. of admissions.
Hygienic Practice During Complementary Feeding and Associated Factors Among Mothers With Children Aged 6-24 Months in Borecha Woreda South Western Ethiopia: Community Based Crossectional Study
Authors: Birdida Rabira Tariku , Kush Efrem Negash , Alemu Fikadu Tolesa , Malka Erean Shigign 
Published: January 2023

AbstractIntroduction:Complementary feeding is a critical time of transition in the life of infant and complementary foods should be hygienically prepared, stored and fed with clean hands, dishes and utensils to prevent diseases. However, Prevalence and risk factors of hygienic complementary feeding practice is not well addressed in Ethiopia especially in study area.Objective: To assess hygienic practices and associated factors during complementary feeding among mothers with children aged 6 to 24 months in Borecha Woreda, Buno Bedele Zone, South Western Ethiopia, 2022.Methods:Community based cross sectional study design with multi-stage sampling technique was employed. The study was conducted on 536 mothers with children aged 6-24 months in the Borecha Woreda from March 1stto April 1st, 2022. Data were collected using interviewer administered structured questionnaire. Data were coded, cleaned, edited and entered into Epi-Data version 4.6 and exported to SPSS version 20.0 for further analysis. Both bivariate and multivariable logistic regression models were fitted. Moreover, Crude (for bivariate) and adjusted (multivariable) odds ratios with 95% confidence intervals was computed to assess the association between independent factors and outcome variables. A p-value < 0.05 was considered as level statically significance.Result:Among 536 respondents, 350 (65.3%) of study participants had poor hygienic practice during complementary feeding. The risk of poor practice among more than 30 years old were about two times [AOR: 1.8 (with 95% CI 1.11, 2.90)] higher than those of less than 25 years old women. Mother whose husband has primary or above education level has a reduction of 50% [AOR: 0.5 (with 95% CI 0.50 (0.31, 0.83)] in the odds of having a poor hygiene care practices during complementary feeding compared to counterpart. The odds of poor hygiene practice among mother with poor knowledge of hygienic care were 2.71 times [AOR: 2.71(95%CI; 1.60, 4.61)] higher than those knowledgeable.Conclusion:The prevalence of poor hygienic practice during complementary food preparation and handling of mothers in Borecha Woreda is high as compared to other studies. Therefore, improving hygiene practice of complementary food preparation requires the responsibility of policy makers, community and family.
Influence of probiotic bacteria feed supplementation on hypopharyngeal glands morphometric measurements of honeybee workers Apis mellifera L
Authors: Hassan Ashwak Abdel-Moneim , Elenany Yasser Essam 
Published: January 2023

Abstract
More scientific study and methods that are compatible with the environment are needed in modern beekeeping to increase the productivity and well-being of honeybees. The goal of the current study set out to investigate the possible effects of probiotics previously isolated from the honeybee intestinal tract and soybean patties on nurse worker bee development, particularly of the hypopharyngeal gland (HPG). More royal jelly can be produced by larger HPGs than by smaller ones. Probiotics and soya beans were administered in the experiment in four separate treatment groups, with control colonies serving as the comparison group. The results showed that there was a significant increase in hypopharyngeal gland morphometric parameters of bees in the experimental group fed probiotic bacteria and soya bean patty. While Control nurse worker bees fed sugar syrup for only two weeks had the smallest hypopharyngeal gland morphometric parameters. The highest HPG diameter 14.89 ± 0.097 µm and surface area 0.065 ± 0.001µm2 were observed in bees group fed with both probiotic and soya patty. Addition the same trend was observed in all morphometric parameter with bees group fed with probiotic bacteria. Thus, the use of probiotics as a natural alternative tool boosted the development of Apis mellifera nurse workers' HPG that will positively affect the beekeepers’ economy by providing a higher yield of royal jelly production.
Whose Cultural Ecosystem Service Values Matter?: Exploring Power Inequities in Diverse Mangrove Communities
Authors: Scott Cinda P. , Mach Leon , Lucas Katherine M. , Myers Anna E. 
Published: January 2023

Abstract

Inequities and unequal power dynamics in the use and distribution of benefits that mangrove forests provide threaten vulnerable coastal regions, communities, and society. Assessing these inequities is challenging as there are difficulties in comprehending and conveying Cultural Ecosystem Services (CES). CES are often contextualized as intrinsically derived, are seen as providing important non-monetary benefits or are lumped into a theoretical bucket for everything that does not fit into established categories or that cannot be easily quantified. Comprehending and conveying CES with nuance and establishing quantifiable benefits is even more difficult when considering different cultural values held within a community. We assessed perceptions of the cultural value of mangrove ecosystems in Bocas del Toro (BDT), Panamá via semi-structured interviews of individuals from culturally diverse groups utilizing two merged conceptual frameworks to highlight the coevolution of differential power dynamics with respect to CES. Three major CES themes were identified: mental health benefits, sense of identity, and inequity. Our findings reveal complex relationships between residents’ appreciation for mangrove environments and long-standing power inequities suggesting the need for CES studies to holistically consider different cultural values within communities. Importantly, our study supports the need for understanding sub-group and ethno-racial understandings of mangrove CES and illuminates the need for more equitable mangrove governance throughout BDT to ensure the protection of mangroves and their cultural benefits to all. Future studies should continue to explore CES frameworks that advance knowledge of locally derived CES benefits and that are inclusive of power and equity dynamics.