bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dynamic crystallography reveals spontaneous anisotropy in cubic GeTe
Authors: Kimber Simon A. J. , Zhang Jiayong , Liang Charles H. , Guzmán-Verri Gian G. , Littlewood Peter B. , Cheng Yongqiang , Abernathy Douglas L. , Hudspeth Jessica M. , Luo Zhong-Zhen , Kanatzidis Mercouri G. , Chatterji Tapan , Ramirez-Cuesta Anibal J. , Billinge Simon J. L. 
Published: February 2023

AbstractCubic energy materials such as thermoelectrics or hybrid perovskite materials are often understood to be highly disordered1,2. In GeTe and related IV–VI compounds, this is thought to provide the low thermal conductivities needed for thermoelectric applications1. Since conventional crystallography cannot distinguish between static disorder and atomic motions, we develop the energy-resolved variable-shutter pair distribution function technique. This collects structural snapshots with varying exposure times, on timescales relevant for atomic motions. In disagreement with previous interpretations3–5, we find the time-averaged structure of GeTe to be crystalline at all temperatures, but with anisotropic anharmonic dynamics at higher temperatures that resemble static disorder at fast shutter speeds, with correlated ferroelectric fluctuations along the <100>c direction. We show that this anisotropy naturally emerges from a Ginzburg–Landau model that couples polarization fluctuations through long-range elastic interactions6. By accessing time-dependent atomic correlations in energy materials, we resolve the long-standing disagreement between local and average structure probes1,7–9 and show that spontaneous anisotropy is ubiquitous in cubic IV–VI materials.
Unidirectional scattering with spatial homogeneity using correlated photonic time disorder
Authors: Kim Jungmin , Lee Dayeong , Yu Sunkyu , Park Namkyoo 
Published: February 2023

AbstractRecently, there has been increasing interest in the temporal degree of freedom in photonics due to its analogy with spatial axes, causality and open-system characteristics. In particular, the temporal analogues of photonic crystals have allowed the design of momentum gaps and their extension to topological and non-Hermitian photonics. Although recent studies have also revealed the effect of broken discrete time-translational symmetry in view of the temporal analogy of spatial Anderson localization, the broad intermediate regime between time order and time uncorrelated disorder has not been examined. Here we theoretically investigate the inverse design of photonic time disorder to achieve optical functionalities in spatially homogeneous platforms. By developing the structure factor and order metric using causal Green’s functions for disorder in the time domain, we propose an engineered time scatterer, which provides unidirectional scattering with controlled scattering amplitudes. We also show that the order-to-disorder transition in the time domain allows the manipulation of scattering bandwidths, which makes resonance-free temporal colour filtering possible. Our work could advance optical functionalities without spatial patterning.
In-depth virological and immunological characterization of HIV-1 cure after CCR5Δ32/Δ32 allogeneic hematopoietic stem cell transplantation
Authors: Jensen Björn-Erik Ole , Knops Elena , Cords Leon , Lübke Nadine , Salgado Maria , Busman-Sahay Kathleen , Estes Jacob D. , Huyveneers Laura E. P. , Perdomo-Celis Federico , Wittner Melanie , Gálvez Cristina , Mummert Christiane , Passaes Caroline , Eberhard Johanna M. , Münk Carsten , Hauber Ilona , Hauber Joachim , Heger Eva , De Clercq Jozefien , Vandekerckhove Linos , Bergmann Silke , Dunay Gábor A. , Klein Florian , Häussinger Dieter , Fischer Johannes C. , Nachtkamp Kathrin , Timm Joerg , Kaiser Rolf , Harrer Thomas , Luedde Tom , Nijhuis Monique , Sáez-Cirión Asier , Schulze zur Wiesch Julian , Wensing Annemarie M. J. , Martinez-Picado Javier , Kobbe Guido 
Published: February 2023

AbstractDespite scientific evidence originating from two patients published to date that CCR5Δ32/Δ32 hematopoietic stem cell transplantation (HSCT) can cure human immunodeficiency virus type 1 (HIV-1), the knowledge of immunological and virological correlates of cure is limited. Here we characterize a case of long-term HIV-1 remission of a 53-year-old male who was carefully monitored for more than 9 years after allogeneic CCR5Δ32/Δ32 HSCT performed for acute myeloid leukemia. Despite sporadic traces of HIV-1 DNA detected by droplet digital PCR and in situ hybridization assays in peripheral T cell subsets and tissue-derived samples, repeated ex vivo quantitative and in vivo outgrowth assays in humanized mice did not reveal replication-competent virus. Low levels of immune activation and waning HIV-1-specific humoral and cellular immune responses indicated a lack of ongoing antigen production. Four years after analytical treatment interruption, the absence of a viral rebound and the lack of immunological correlates of HIV-1 antigen persistence are strong evidence for HIV-1 cure after CCR5Δ32/Δ32 HSCT.
A wearable platform for closed-loop stimulation and recording of single-neuron and local field potential activity in freely moving humans
Authors: Topalovic Uros , Barclay Sam , Ling Chenkai , Alzuhair Ahmed , Yu Wenhao , Hokhikyan Vahagn , Chandrakumar Hariprasad , Rozgic Dejan , Jiang Wenlong , Basir-Kazeruni Sina , Maoz Sabrina L. , Inman Cory S. , Stangl Matthias , Gill Jay , Bari Ausaf , Fallah Aria , Eliashiv Dawn , Pouratian Nader , Fried Itzhak , Suthana Nanthia , Markovic Dejan 
Published: February 2023

AbstractAdvances in technologies that can record and stimulate deep brain activity in humans have led to impactful discoveries within the field of neuroscience and contributed to the development of novel therapies for neurological and psychiatric disorders. Further progress, however, has been hindered by device limitations in that recording of single-neuron activity during freely moving behaviors in humans has not been possible. Additionally, implantable neurostimulation devices, currently approved for human use, have limited stimulation programmability and restricted full-duplex bidirectional capability. In this study, we developed a wearable bidirectional closed-loop neuromodulation system (Neuro-stack) and used it to record single-neuron and local field potential activity during stationary and ambulatory behavior in humans. Together with a highly flexible and customizable stimulation capability, the Neuro-stack provides an opportunity to investigate the neurophysiological basis of disease, develop improved responsive neuromodulation therapies, explore brain function during naturalistic behaviors in humans and, consequently, bridge decades of neuroscientific findings across species.
NLRC3 is a potential prognostic biomarker that is correlated with immune cell infiltration in lung adenocarcinoma
Authors: Zhuo Yingchen , Li Xueqian , Feng Weiyi 
Published: February 2023

AbstractThe NLR family CARD domain containing 3 (NLRC3) gene has been reported to have a crucial effect on immunity, inflammation, and tumorigenesis. However, the clinical relevance of NLRC3 in lung adenocarcinoma (LUAD) remains unclear. This study analyzed both RNA sequencing data and corresponding clinical outcomes obtained from public databases to identify (i) NLRC3 as a tumor suppressor in LUAD and (ii) its predictive value for the likelihood of patient responsiveness to immunotherapy. The results showed that NLRC3 expression was reduced in LUAD and was lower in advanced-stage tumors. Additionally, reduced NLRC3 expression was correlated with worse patient prognosis. The protein level of NLRC3 was also observed to have prognostic significance. Moreover, downregulation of NLRC3 was found to suppress the chemotaxis and infiltration of antitumor lymphocyte subpopulations as well as natural killer cells. Mechanistic analysis indicated that NLRC3 may be involved in immune infiltration by regulating chemokines and their receptors in LUAD. Furthermore, NLRC3 functions as a molecular switch in macrophages, whereby it mediates the polarization of M1 macrophages. Patients with high NLRC3 expression were also found to exhibit a more promising response to immunotherapy. In conclusion, NLRC3 could serve as a potential prognostic biomarker for LUAD, help predict the immunotherapeutic response of patients, and guide personalized strategies for the treatment of LUAD.
Efficient plasma electron accelerator driven by linearly chirped multi-10-TW laser pulses
Authors: Grigoriadis A. , Andrianaki G. , Tazes I. , Dimitriou V. , Tatarakis M. , Benis E. P. , Papadogiannis N. A. 
Published: February 2023

AbstractThe temporal rearrangement of the spectral components of an ultrafast and intense laser pulse, i.e., the chirp of the pulse, offers significant possibilities for controlling its interaction with matter and plasma. In the propagation of ultra-strong laser pulses within the self-induced plasma, laser pulse chirp can play a major role in the dynamics of wakefield and plasma bubble formation, as well as in the electron injection and related electron acceleration. Here, we experimentally demonstrate the control of the generation efficiency of a relativistic electron beam, with respect to maximum electron energy and current, by accurately varying the chirp value of a multi-10-TW laser pulse. We explicitly show that positively chirped laser pulses, i.e., pulses with instantaneous frequency increasing with time, accelerate electrons in the order of 100 MeV much more efficiently in comparison to unchirped or negatively chirped pulses. Corresponding Particle-In-Cell simulations strongly support the experimental results, depicting a smoother plasma bubble density distribution and electron injection conditions that favor the maximum acceleration of the electron beam, when positively chirped laser pulses are used. Our results, aside from extending the validity of similar studies reported for PW laser pulses, provide the ground for understanding the subtle dynamics of an efficient plasma electron accelerator driven by chirped laser pulses.
Beneficial behavioral effects of chronic cerebral dopamine neurotrophic factor (CDNF) infusion in the N171-82Q transgenic model of Huntington’s disease
Authors: Stepanova P. , Kumar D. , Cavonius K. , Korpikoski J. , Sirjala J. , Lindholm D. , Voutilainen M. H. 
Published: February 2023

AbstractHuntington’s disease (HD) is a progressive inherited neurological disease characterized by the degeneration of basal ganglia and the accumulation of mutant huntingtin (mHtt) aggregates in specific brain areas. Currently, there is no treatment for halting the progression of HD. Cerebral dopamine neurotrophic factor (CDNF) is a novel endoplasmic reticulum located protein with neurotrophic factor properties that protects and restores dopamine neurons in rodent and non-human primate models of Parkinson’s disease. Our recent study showed that CDNF improves motor coordination and protects NeuN positive cells in a Quinolinic acid toxin rat model of HD. Here we have investigated the effect of chronic intrastriatal CDNF administration on behavior and mHtt aggregates in the N171-82Q mouse model of HD. Data showed that CDNF did not significantly decrease the number of mHtt aggregates in most brain regions studied. Notably, CDNF significantly delayed the onset of symptoms and improved motor coordination in N171-82Q mice. Furthermore, CDNF increased BDNF mRNA level in hippocampus in vivo in the N171-82Q model and BDNF protein level in cultured striatal neurons. Collectively our results indicate that CDNF might be a potential drug candidate for the treatment of HD.
Long-term visual acuity outcome of pediatric uveitis patients presenting with severe visual impairment
Authors: Tungsattayathitthan Usanee , Rattanalert Narisa , Sittivarakul Wantanee 
Published: February 2023

AbstractThis study investigated the long-term visual acuity (VA) outcome in the eyes of children with uveitis and severe visual impairment (SVI; VA ≤ 20/200) at presentation. Fifty-one children [57 eyes; median age, 11 years; 51% female; median follow-up period, 36 months (interquartile range 14.9–64.4)] aged ≤ 16 years with uveitis managed at our tertiary center from January 2010 to July 2020 were reviewed. Uveitis mainly manifested as unilateral (74.5%), chronic course (82.4%), and panuveitis (43.1%). Ocular toxoplasmosis and toxocariasis were the most common diagnoses (9.8% each). At least one ocular complication at presentation was observed in 93% of the eyes. Overall, the mean logMAR VA improved from 1.8 at presentation to 1.2 at 5 years (P < 0.001). Common causes of poor vision included retinal detachment, atrophic bulbi, and optic atrophy. Predictive factors associated with less VA improvement over the follow-up period included preschool age of uveitis onset (P < 0.001), ocular symptoms duration before uveitis diagnosis ≥ 1 month (P = 0.004), and non-anterior uveitis (P = 0.047). The long-term VA outcome in uveitis-affected eyes with SVI at presentation was unfavorable. Younger age at uveitis onset, delayed presentation, and uveitis involving the posterior segment were associated with poorer VA outcome.
Frequency-specific brain network architecture in resting-state fMRI
Authors: Kajimura Shogo , Margulies Daniel , Smallwood Jonathan 
Published: February 2023

AbstractThe analysis of brain function in resting-state network (RSN) models, ascertained through the functional connectivity pattern of resting-state functional magnetic resonance imaging (rs-fMRI), is sufficiently powerful for studying large-scale functional integration of the brain. However, in RSN-based research, the network architecture has been regarded as the same through different frequency bands. Thus, here, we aimed to examined whether the network architecture changes with frequency. The blood oxygen level-dependent (BOLD) signal was decomposed into four frequency bands—ranging from 0.007 to 0.438 Hz—and the clustering algorithm was applied to each of them. The best clustering number was selected for each frequency band based on the overlap ratio with task activation maps. The results demonstrated that resting-state BOLD signals exhibited frequency-specific network architecture; that is, the networks finely subdivided in the lower frequency bands were integrated into fewer networks in higher frequency bands rather than reconfigured, and the default mode network and networks related to perception had sufficiently strong architecture to survive in an environment with a lower signal-to-noise ratio. These findings provide a novel framework to enable improved understanding of brain function through the multiband frequency analysis of ultra-slow rs-fMRI data.
Modulation of transcription factor dynamics allows versatile information transmission
Authors: Givré Alan , Colman-Lerner Alejandro , Ponce Dawson Silvina 
Published: February 2023

AbstractCells detect changes in their environment and generate responses, often involving changes in gene expression. In this paper we use information theory and a simple transcription model to analyze whether the resulting gene expression serves to identify extracellular stimuli and assess their intensity when they are encoded in the amplitude, duration or frequency of pulses of a transcription factor’s nuclear concentration (or activation state). We find, for all cases, that about three ranges of input strengths can be distinguished and that maximum information transmission occurs for fast and high activation threshold promoters. The three input modulation modes differ in the sensitivity to changes in the promoters parameters. Frequency modulation is the most sensitive and duration modulation, the least. This is key for signal identification: there are promoter parameters that yield a relatively high information transmission for duration or amplitude modulation and a much smaller value for frequency modulation. The reverse situation cannot be found with a single promoter transcription model. Thus, pulses of transcription factors can selectively activate the “frequency-tuned” promoter while prolonged nuclear accumulation would activate promoters of all three modes simultaneously. Frequency modulation is therefore highly selective and better suited than the other encoding modes for signal identification without requiring other mediators of the transduction process.
Multiple metrics assessment method for a reliable evaluation of corneal suturing skills
Authors: Dormegny Lea , Neumann Nicole , Lejay Anne , Sauer Arnaud , Gaucher David , Proust François , Chakfe Nabil , Bourcier Tristan 
Published: February 2023

AbstractThis study aimed to evaluate the efficiency of a multiple metrics assessment method to differentiate between surgeons of differing experience while performing a corneal suturing task. Volunteer ophthalmologists were assigned to three groups (senior [SG], junior [JG] and novice [NG]) according to their experience in corneal suturing. All participants performed three sessions of corneal wound closure by three stitches. Suturing and participant posture were recorded with cameras, and assessed by two blind assessors for stitch quality (using Zhang score) and ergonomics (using Rapid Upper Limb Assessment [RULA] score). Task duration was recorded. Objective analyses of stitches geometry and instrument position were carried out. We included 24 participants: 5 in the SG, 8 in the JG and 11 in the NG. Stitch quality was significantly better and time to perform the procedure significantly lower in more experienced groups (p < 0.001 and p = 0.002, respectively). SG participants better respected regular distance and parallelism between stitches compared to others (p = 0.01). Instrument position was similar between groups, although SG participants minimized their back-and-forth movements compared to NG participants. Ergonomics assessment was similar. Multiple metrics assessment efficiently determined how to differentiate between novices and experienced surgeons on corneal suturing skills, providing hints for future training studies.
Mindfulness training reduces slippery slope effects in moral decision-making and moral judgment
Authors: Du Wei , Yu Hongbo , Liu Xinghua , Zhou Xiaolin 
Published: February 2023

AbstractExtant research has demonstrated the positive intrapersonal effects of mindfulness training. However, the cognitive mechanisms underlying the effects of mindfulness training on interpersonal processes are less clear. Here, we combined a randomized control mindfulness training design with computational approach to moral decision-making and moral judgments. Participants were randomly assigned to a Training group (N = 32) who received an 8-week mindfulness training or a Control group (N = 26) who waited for the same period of time. Before and after the 8-week period, participants completed a moral decision-making task, where they made tradeoff between money for themselves and unpleasant electric shocks to another person, and a moral judgment task, where they evaluated the blameworthiness of someone else’s choices in the same moral decision-making task. Trait mindfulness, as measured by the Five-Facet Mindfulness Questionnaire, significantly increased from the pre- to post-training session for the Training group, but not the Control group, demonstrating the effectiveness of the mindfulness manipulation. For the Control group, participants’ moral preference in both the decision-making task and the judgment task declined over time, exhibiting a “slippery slope” effect. In contrast, for the Training group, mindfulness training prevented moral preferences from declining. Computational modeling revealed that mindfulness training specifically reduced the increase in the weights of money over time in both the decision-making and judgment tasks, thereby curbing the “slippery slope” effects. These findings provide a cognitive account of the prosocial effects of mindfulness training on moral decision-making and moral judgments.
Exploring the impact of COVID-19 on newborn neurodevelopment: a pilot study
Authors: Ayesa-Arriola Rosa , Castro Quintas Águeda , Ortiz-García de la Foz Víctor , Miguel Corredera Margarita , San Martín González Nerea , Murillo-García Nancy , Neergaard Karl , Fañanás Saura Lourdes , de las Cuevas-Terán Isabel 
Published: February 2023

AbstractThe COVID-19 pandemic can seize the opportunity to explore the hypothesis of prenatal exposure to viral infections increases the risk for neurodevelopmental disorders. Advancing our knowledge in this regard would improve primary prevention of mental disorders in children. For this pilot study, six-week-old infants born to mothers exposed (n = 21) or unexposed (n = 21) to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) were assessed in Santander-Cantabria (Spain) using the Neonatal Behavioral Assessment Scale (NBAS). Groups comparisons were performed to explore the effects that infection and timing of exposure (in terms of the three trimesters of pregnancy). The infants’ competencies and performances on the NBAS were generally similar in the exposed and unexposed to SARS-CoV-2 groups. The most significant difference found was a less optimally response to cuddliness (item on the state regulation domain) particularly in infants born to mothers exposed in the third trimester of pregnancy, and in pull-to-sit (item on the motor system domain). Although our interpretations must be careful, these preliminary results highlight the possible association between prenatal SARS-CoV-2 exposure and poorer development in motor skills and infant interactive behavior. Further longitudinal studies are needed to explore these relationships and disentangle the biological mechanisms implicated.
Influence of surgical position and registration methods on clinical accuracy of navigation systems in brain tumor surgery
Authors: Furuse Motomasa , Ikeda Naokado , Kawabata Shinji , Park Yangtae , Takeuchi Koji , Fukumura Masao , Tsuji Yuichiro , Kimura Seigo , Kanemitsu Takuya , Yagi Ryokichi , Nonoguchi Naosuke , Kuroiwa Toshihiko , Wanibuchi Masahiko 
Published: February 2023

AbstractThe aim of this study was to evaluate the influence of skin distortion due to surgical positioning on the clinical accuracy of the navigation system. The distance errors were measured in four fiducial markers (anterior, posterior, right, and left of the head) after the registration of the navigation system. The distance errors were compared between the surface-merge registration (SMR) method using preoperative imaging and the automatic intraoperative registration (AIR) method using intraoperative imaging. The comparison of the distance errors were performed in various surgical positions. The AIR method had the significant accuracy in the lateral markers than the SMR method (lateral position, 3.8 mm vs. 8.95 mm; p < 0.0001; prone position, 4.5 mm vs. 13.9 mm; p = 0.0001; 5.2 mm vs. 11.5 mm; p = 0.0070). The smallest distance errors were obtained close to the surgical field in the AIR method (3.25–3.85 mm) and in the forehead in the SMR method (3.3–8.1 mm). The AIR method was accurate and recommended for all the surgical positions if intraoperative imaging was available. The SMR method was only recommended for the supine position, because skin distortion was frequently observed in the lateral region.