bluuebunny/crossref_metadata_2025_split huggingface dataset:
The fiber saturation point: does it mean what you think it means?
Authors: Fredriksson Maria , Thybring Emil Engelund , Zelinka Samuel L. , Glass Samuel V. 
Published: February 2025

Abstract
Wood–water interactions are central to wood science, technology, and engineering. In the early twentieth century, the term “fiber saturation point” was coined to refer to the point of transition from the domain where wood properties change with moisture content to the domain where wood properties are constant. This conceptual model assumed that the wood cell walls are water saturated at this transition point and that capillary water appears above this point. This has since then been contradicted by multiple studies. Additionally, the fiber saturation point has been associated with techniques that do not necessarily measure the same moisture state. Some techniques characterize either the transition state at which wood properties change, or the state at which the cell walls are water saturated. These are, however, not the same moisture state. The aim of this paper is to clarify which moisture states the various fiber saturation points represent discussed from a conceptual model consistent with current experimental evidence. To avoid confusion, we propose that the transition state at which wood properties change is the only state called “the fiber saturation point”, or, for even more clarity, “the property intersection point”. For other moisture states, we strongly recommend that the term fiber saturation point is avoided. The term “maximum cell wall moisture content” should be used for the state at which the cell walls are water saturated. Finally, we highlight the importance of considering which moisture state is relevant for a specific application and selecting an appropriate method to characterize that state.
Exploring Mothers’ Experiences of an Online Musical Parenting Educational Program
Authors: Papazachariou-Christoforou Maria 
Published: February 2025

Abstract
The purpose of this study was to investigate the experiences of a group of mothers who participated in an online musical parenting educational program. The participants comprised 18 mothers with infants from birth to 12 months old. This study was conducted for 6 months using qualitative research methods: semi-structured interviews and informal discussions with mother-participants, participants’ digital journals and filmed videos, and researcher field notes taken during the educational program. Findings revealed that during the program, mothers engaged in multimodal musical interaction with their infants, which facilitated a dynamic state of attunement within the mother-infant dyad. Active participation in the educational program fostered mothers’ confidence in using music as a parenting tool and enhanced conscious musical parenting practices with their infants. I discuss implications for musical parenting educational programs and research.
Screening-level ecological risk assessment (SLERA) in an abandoned As–Cu mining area (N Spain): implications of phyto-availability and soil properties on vegetation
Authors: Serrano-García Humberto , Izquierdo-Díaz Miguel , Barrio-Parra Fernando , Álvarez Rodrigo , Ordóñez Almudena , De Miguel Eduardo 
Published: February 2025

Abstract
This study applies a Screening-Level Ecological Risk Assessment (SLERA) to evaluate the potential impact of trace elements on vegetation in an abandoned As–Cu mining area in northern Spain. A total of 27 soil samples were analyzed for pseudo-total (aqua regia) and phyto-available (EDTA 0.05 M) content of As, Cd, Co, Cr, Cu, Ni, Pb and Zn. Contamination and ecotoxicological risk indices were used to identify pollution hotspots and contaminants of ecological concern (COPEC). Arsenic, Cu, Co and Zn pose a potential risk to vegetation across the site. Available concentrations of these elements are high, although average phyto-availabilities are generally low (< 30%). Remarkably, some highly contaminated areas support vegetation, while others remain barren. This suggests that high phyto-available concentrations alone do not fully explain the presence or absence of vegetation. Edaphic properties, such as low soil pH and minimal organic matter content, seem to play a critical role in inhibiting vegetation growth in certain areas. These results underline the importance of considering not only trace element concentrations but also site-specific edaphic properties when assessing ecological risk and planning remediation strategies in contaminated mining areas.
Puzzle-based movable rack system with diagonal movements and class-based storage policy
Authors: Weerasinghe Kasuni Vimasha , Sgarbossa Fabio , Fede Giulia 
Published: February 2025

Abstract
There is a rising need for responsive and innovative compact storage solutions to handle fluctuating demand volumes. When compared to other traditional storage systems, Puzzle-based storage (PBS) systems are better suited to handle high demand in small or compact storage. However, achieving high throughput often remains a challenge for these systems. This paper studies a new paradigm of PBS proposed as a result of the collaboration between Logistics 4.0 lab and the Norwegian company Wheel.me. This solution, called Puzzle-Based Movable Rack (PBMR) system, enables achieving together a high storage density and high throughput, and it is characterized by storage racks mounted on autonomous wheels. These autonomous wheels can move in any direction including diagonal movements, which could result in high throughput. In this study, we employed a PBMR system with diagonal movement and a class-based storage policy. Under the above configurations, we identified optimal first zone percentages that can minimize the average travel time. Further, we optimized the system performance while understanding the impact of different input parameters such as capacity and shape of the system, and demand profile to the optimal first zone.
Autistic Burnout on Reddit: A Sisyphean Struggle with Daily Tasks
Authors: Clarey Megan M. , Abel Susan , Ireland Michael J. , Brownlow Charlotte 
Published: February 2025

Abstract
The crippling impacts of autistic burnout are well known to the autistic community, yet research is only in its early stages. While research to date has chiefly relied on structured interviews and Delphi studies, it has focused on defining and measuring burnout. What is missing from the research is an analysis of the broader experiences of autistic burnout, and the very real implications that autistic people face when impacted by it. This study reviewed the narratives of autistic people discussing their experiences of autistic burnout on the social media platform Reddit. Using data scraped from Reddit, quantitative and qualitative analyses were undertaken to elicit meaning from the online discourse. After analysing 249 Reddit threads using quantitative content analysis, the results supported existing research identifying three core components of autistic burnout, those being: chronic exhaustion; increased sensory sensitivities; and social withdrawal. New insights were found with users reporting physiological ailments as a complicating factor in their burnout experience. The research also found evidence supporting suggested treatment options for autistic burnout including reducing/stopping social obligations, reducing sensory inputs as much as possible, and time spent alone to reset and recharge. Most importantly, users identified that being autonomous in their recovery choices was critical to the success of their recovery.
Enantioselective cyclopropanations: a study on the catalytic effects of methyl-α-D-mannopyranoside-based lariat ethers
Authors: Orbán István , Ujj Dóra , Mátravölgyi Béla , Rapi Zsolt 
Published: February 2025

Abstract
Novel monoaza-15-crown-5 ethers have been synthesized with an α-d-mannopyranoside backbone. These chiral catalysts contain different heteroaromatic side chains, which have never been incorporated in sugar-based crown ethers before. The novel macrocycles together with a few previously synthesized mannose-based crown ethers were examined in four asymmetric phase-transfer cyclopropanations. The reactions proceeded mainly with excellent yields (up to 99%), while enantiomeric excesses ranged from 1 to 44%, proving the mannose-based lariat ethers to be moderate enantioselective catalysts in these reactions. The distance between the crown ring and the functional group of the side chain proved to be important in terms of enantioselectivity, the propylene moiety was more favorable than the ethylene bridge. The type of heteroaromatic ring also affected the catalytic activity of the mannose-based macrocycles, using lariat ethers containing a pyrrole unit, higher enantiomeric excess was measured.
A Comparison of the Long and Short Forms of the Penn State Worry Questionnaire in Adults with Generalised Anxiety Disorder
Authors: Wilson Emily J. , Abbott Maree J. , Norton Alice R. , Berle David , Stapinski Lexine , Rapee Ronald M. 
Published: February 2025

Abstract
The Penn State Worry Questionnaire (PSWQ) is a 16-item self-report measure designed to assess pathological worry. The PSWQ has, however, demonstrated inconsistent factor structure in adults and older adults leading to the development of the 8-item PSWQ-A and the ultra-brief 3-item PSWQ-3. The PSWQ is yet to be compared to the PSWQ-A and PSWQ-3 in adults with generalised anxiety disorder (GAD). Thus, the current study aimed to evaluate the psychometric properties of these three versions. Participants were screened using the Anxiety Disorders Interview Schedule for DSM-IV-TR to ascertain clinical principal diagnosis of GAD (n = 140) or non-clinical status (n = 76). Four different confirmatory factor models were fit to the 16-item PSWQ, with a unidimensional model fit to the 8-item PSWQ-A and to the PSWQ-3. A bifactor model fitted the data best for the PSWQ, and a unidimensional PSWQ-A model fitted the data best for the GAD sample. Results found that all three versions of the PSWQ demonstrated good construct validity, moderate test-retest reliability, and excellent criterion validity. ROC curve analysis indicated that all three versions demonstrated comparable levels of sensitivity and specificity for screening GAD. Both the PSWQ-A and PSWQ demonstrated no floor or ceiling effects and good internal consistency, whereas the PSWQ-3 demonstrated floor effects with adequate internal consistency. Overall, all three versions of the PSWQ share comparable psychometric properties. As such, the brevity of the PSWQ-A and its comparable performance to the 16-item PSWQ, warrant recommendations for use of this version to researchers and clinicians.
Eating to Feel Better: The Role of Comfort Eating in Chronic Pain
Authors: Roche Claudia , Burton Amy , Newton-John Toby 
Published: February 2025

Abstract
Research has identified that individuals with chronic pain comfort eat in response to their pain, however, little is known about the function that comfort eating serves for chronic pain patients. Given the synergistic relationship between higher body weight and chronic pain, it is important to further understand the role and impact of eating behaviours, such as comfort eating, for individuals with chronic pain. This study aimed to investigate the perceived function of pain-induced comfort eating for chronic pain sufferers. Adult participants (N = 141) with chronic pain were recruited through online advertisements. Participants completed self-report questions on an online survey platform. Over two-thirds of the sample identified with engaging in comfort eating in response to chronic pain flare-ups. Results revealed that the most endorsed function of pain-induced comfort eating was ‘to have a pleasant experience’ (51.8%), followed by ‘distraction’ (49.6%) and ‘to reduce emotions’ (39%). This study provides further evidence that comfort eating is common amongst individuals with chronic pain and sheds light on the perceived function of comfort eating for those who are managing chronic pain. Given the potential impact on outcomes for chronic pain patients, future studies should further investigate the relationship between comfort eating and chronic pain.
Barriers and Facilitators for Interprofessional Education in Work-Focused Healthcare: An Integrative Review
Authors: Zwaan Elmi , Zipfel Nina , Kuijer-Siebelink Wietske , Oomens Shirley , van der Burg-Vermeulen Sylvia J. 
Published: February 2025

Abstract

Purpose
To identify, summarize, and synthesize barriers and facilitators associated with interprofessional education (IPE) for work-focused healthcare professionals such as occupational physicians, social insurance physicians, and labor experts, to inform and stimulate interprofessional collaborative practice within the field of work-focused healthcare.

Methods
An integrative review was conducted to identify studies that report on IPE for work-focused healthcare professionals. Eight databases (APA PsycInfo, CINAHL, Cochrane, Embase, ERIC, Google Scholar, PubMed, Web of Science) were searched until March 2024. Reference lists of included articles were screened. Inclusion criteria were a description of an IPE activity of which at least one group of participants were work-focused healthcare professionals (in training). Barriers and facilitators were structured using the framework of Measurement Instruments for Determinants of Innovation (MIDI).

Results
From 6123 studies, seven were included. Barriers and facilitators were identified for each level of the MIDI framework. For example, at the level of characteristics of the IPE activity, involvement of skilled educators and reflection opportunities facilitated IPE. At the level of characteristics of IPE participants, role misunderstanding and lack of interaction hindered IPE. At the level of the organizational context, connection to work practice facilitated IPE. At the level of socio-political context, lack of support from external organizations hindered IPE.

Conclusion
Insights from this review can inform future IPE development. It is recommended that IPE is integrated in a learning continuum, is connected to daily practice, and includes reflection possibilities and training for interprofessional competencies.
Enhanced stability of curcumin and polyethylene glycol composites in the presence of flavonoids and whey protein concentrate: synthesis, structural evaluation and thermal analysis
Authors: Tomoaia-Cotisel Maria , Kun Attila-Zsolt , Rácz Csaba-Pál , Tomoaia Gheorghe , Mocanu Aurora , Forizs Edit , Avram Alexandra , Rácz Levente-Zsolt , Pop Lucian-Cristian , Sarkozi Melinda , Várhelyi Csaba 
Published: February 2025

Abstract
Curcumin (CCM) is a natural polyphenol with promising pharmacological potential. This potential is severely restricted, however, due to its limited bioavailability, poor solubility and stability. To address this, several systems of curcumin and polyethylene glycol, PEG (PEG4000 or PEG6000), were synthetized, with or without whey protein concentrate (WPC), trans-resveratrol (RES) or silymarin (SIL) using solid dispersion technique. Firstly, CCM-PEG composites were synthesized using PEG4000 or PEG6000 for 1:8 mol ratio by polymer melting method. Further, the CCM-WPC-PEG4000 composite for 1:0.4:8 mol ratio and CCM-WPC-PEG6000 composite for 1:0.5:10 mol ratio were synthesized. Furthermore, CCM-RES-WPC-PEG and CCM-SIL-WPC-PEG composites were prepared for 1:2.5:0.4:10 mol ratio for PEG4000 or PEG6000. The composite formation was investigated by Fourier transform infrared spectroscopy (FTIR). The thermal stability of synthesized composites was analyzed through thermal gravimetric analysis (TGA) and differential scanning calorimetry (DSC) revealing a high stability up to 200 °C. Thus, each composite formulation was optimized to carry CCM, RES and WPC or CCM, SIL and WPC within PEG matrix primarily by hydrogen bonds and van der Waals interactions. This study demonstrated that all synthesized composites may have potential advantages for applications such as nutraceuticals, functional foods, supplements and pharmaceuticals.
Urban pollinator communities are structured by local-scale garden features, not landscape context
Authors: Sexton Aaron N. , Conitz Felix , Karlebowski Susan , Neumann Astrid E. , Schmack Julia Marion , Sturm Ulrike , Egerer Monika 
Published: February 2025

Abstract

Context
Understanding the drivers of urban pollinator communities is relevant to both biodiversity conservation and sustainable agriculture, particularly in urban community gardens. However, much interest has been placed on bee communities, focused on bee species alpha diversity and which large-scale factors predict their occurrence and abundance.

Objectives
In this study we build on previous urban bee work by investigating how a suite of specific local-scale garden features and landscape context influence the composition of the entire arthropod flower visiting community in urban agroecosystems.

Methods
We conducted pollinator observations in 33 gardens across two large German cities, Berlin & Munich, over two years. We then tested the influence of local-scale and landscape-scale factors on pollinator community composition, and beta diversity.

Results
Across the two cities, local-scale garden features predominantly influenced pollinator communities in urban community gardens, more so than landscape context. Features such as vegetation height, floral and woody plant richness and bare soil cover significantly influenced pollinator community composition—leading to a dominance of preferable taxa such as bees, butterflies and hoverflies, while garden size and urbanization did not. Beta diversity of pollinator communities did not decrease along an urbanization gradient indicating no urban homogenization impact on the full pollinator community.

Conclusions
Decisions made at the local garden scale can significantly influence pollinator communities and their floral resources. As we found that garden features can support beneficial taxa that provide important ecosystem services in urban agroecosystems, gardeners and practitioners can focus on implementing these features to support pollinators and therefore garden productivity.
Scalable and Sustainable DMF-Free Solid-Phase Synthesis of Liraglutide by 1-Tert-Butyl-3-Ethylcarbodiimide-Mediated Couplings and Catch-and-Release Acylation and Purification Strategies
Authors: Pacini Lorenzo , Muthyala Manoj Kumar , Zitterbart Robert , Marder Oleg , Rovero Paolo , Papini Anna Maria 
Published: February 2025

Abstract

Introduction
The growing need for sustainable practices in pharmaceutical manufacturing has stimulated advancements in peptide synthesis. This study focuses on applying green chemistry principles to the synthesis of the Glucagon-Like Peptide-1 analog liraglutide.

Material and Methods
The safer coupling reagent 1-tert-butyl-3-ethylcarbodiimide (TBEC) was tested in combination with eco-friendly binary solvents such as dimethyl sulfoxide and butyl acetate to propose novel and sustainable solid-phase synthetic and purification strategies of liraglutide.

Results
Two synthetic strategies were developed for liraglutide production. The first strategy was based on a “direct synthesis”, incorporating a lipidated lysine building block into the peptide sequence, achieving 86% HPLC purity after catch-and-release purification. The second strategy based on “catch-lipidation-and-release” approach, allowed to obtain the peptide precursor without the lipid moiety, which was later linked during a controlled lipidation step. This latter strategy yielded purities exceeding 90% and reduced reliance on preparative HPLC. TBEC minimizes hazardous byproducts, such as hydrogen cyanide, and enhances solvent compatibility, achieving crude purities and yields comparable to conventional syntheses.

Conclusion
This work underscores the potential of green chemistry to align pharmaceutical innovation with environmental responsibility. In particular our findings highlight the effectiveness of TBEC and green solvent systems optimizing scalable and sustainable SPPS processes and improving resource efficiency. Thus, we propose a viable pathway to produce the therapeutic peptide ingredient liraglutide significantly reducing the environmental impact while maintaining high efficiency and quality of the synthesis.
Design and synthesis of novel pyrimidine-pyrazole hybrids with dual anticancer and anti-inflammatory effects targeting BRAFV600E and JNK
Authors: Abdel-Maksoud Mohammed S. , Eitah Hebatollah E. , Hassan Rasha M. , Abd-Allah Walaa Hamada 
Published: February 2025

Abstract
Two new series of pyrimidinyl ethyl pyrazoles derivatives 13a–f and 14a–f were designed and synthesized to possess both anticancer effect by inhibiting BRAFV600E and anti-inflammatory effect by inhibiting JNK isoforms. The structure of the new compounds was generated from hybridization of two main moieties. The pyrimidinyl moiety from reported BRAFV600E inhibitors, and the pyrazole moiety from JNK isoforms inhibitors. The new final compounds were tested on BRAFV600E, JNK1, JNK2, and JNK3 to measure their kinases inhibitory effect. Compound 14c showed the highest activity on JNK isoforms and BRAFV600E with IC50 = 0.51 μM, 0.53 μM, 1.02 μM, 0.009 μM on JNK1, JNK2, JNK3,and BRAFV600E, respectively. All final compounds were tested over four cancer cell lines related to the target enzymes. Compound 14d showed the most potent activity on all tested cell lines with IC50 = 0.87 μM, 0.91, 0.42 μM and 0.63 μM on MOLT-4, K-562, SK-MEL-28, and A375 cell lines, respectively. The ability of 14d and 14c to inhibit MEK1/2 and ERK1/2 phosphorylation was performed by using western blot. The cell cycle analysis of compound 14d on A375 cell line revealed that compound 14d arrested cell growth at G0-G1 phase. Compound 14d remarkably decreased cell migration compared to control group in traditional migration test. Compounds 13a–f and 14a–f showed significant ability to inhibit nitric oxide release and PGE2 production on raw 264.7 macrophages. Compounds 13d and 14d exhibited high inhibitory effect on iNOS and COX-2 compared to COX-1. Finally, the effect of most potent compounds on TNF-alpha and IL-6 was determined.

Graphical abstract

Two new series of pyrimidinyl ethyl pyrazoles were synthesized. The new derivatives were able to inhibit both JNK isoforms and BRAFV600E. JNK and BRAFV600E play a key role in both cancer and inflammatory disorders. Final compounds were tested for their anticancer and anti-inflammatory activities.
Unstable limit cycle estimation from small perturbations: a minimal-data-driven approach
Authors: Habib Giuseppe 
Published: February 2025

Abstract
While stable solutions of dynamical systems are generally regarded as more significant than unstable ones, the latter play a crucial role in the dynamical integrity of stable steady-states. In fact, the boundaries of basins of attraction are often formed by unstable saddle-type solutions and their stable manifolds. This study proposes a method for estimating unstable limit cycles surrounding stable equilibrium points. The method leverages the shape of trajectories converging towards the equilibrium. Trajectories from small perturbations near the equilibrium state are sufficient to provide an acceptable estimate of the unstable limit cycle. No mathematical model of the system dynamics is required for the computation, which relies on just a single trajectory in the phase space. Consequently, the method is computationally efficient and can potentially be implemented in real-world structures.