bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of Adjuvant Chemotherapy on Survival Benefit in T1N0 Triple Negative Breast Cancer Based on SEER Database by Age Group
Authors: Wang Shu , Sun Jian , Gao JiaLiang 
Published: June 2023

Abstract
BACKGROUND
We aimed to analyze the survival benefit of adjuvant chemotherapy in patients with T1N0M0 triple-negative breast cancer (TNBC) (age-stratified and tumor size-stratified) to guide more precise treatment.
METHODS
This study recruited 6482 pT1N0M0 TNBC patients from 2010–2015 in the SEER database (*Stat 8.3.6 software). The χ[2] test was used to compare categorical variables between different tumor sizes. OS and BCSS of patients with T1mic, T1a, T1b and T1cN0M0 TNBC were studied and Kaplan-Meier survival curves were plotted for the prognosis of patients receiving versus not receiving chemotherapy stratified by age and tumor size.
RESULTS
A total of 6482 T1N0M0 TNBC patients were included in this study, with a total of 4244 (65.47%) patients receiving adjuvant chemotherapy and 2238 (34.53%) not receiving adjuvant chemotherapy, whose 5-year OS was 92.4% and 85.4% (p < 0.001) and 5-year BCSS was 95.1% and 94.9% (p = 0.46), respectively. Among them, 15.2% (16/105), 24.5% (159/650), 58.7% (1046/1781), and 76.6% (3023/3946) received chemotherapy for T1mic, T1a, T1b, and T1c, respectively. The 5-year OS with and without chemotherapy was 93.3% vs. 94.7% (p = 0.95), 98.7% vs. 94.4% (p = 0.004), 94.8% vs. 87.7% (p < 0.001), and 91.2% vs. 77.0% (p < 0.001), respectively, and the 5-year BCSS was 100% vs. 93.3% (p = 0.026),99.3% vs 98.1% (p = 0.22), 96.9% vs 96.3% (p = 0.36), and 94.3% vs 91.4% (p < 0.001), respectively. Among the T1mic patients, receiving chemotherapy did not improve OS (p = 0.95), but instead decreased BCSS (p = 0.026). When patients were stratified by age, it was found that for age > 65 years, T1a patients receiving chemotherapy did not improve OS and BCSS (p = 0.07, p = 0.45). For T1b patients, receiving chemotherapy at age > 75 years did not improve OS and BCSS (p = 0.065, p = 0.13). For T1c patients, receiving chemotherapy did not improve OS and BCSS at age > 80 years (p = 0.19, p = 0.15).
CONCLUSION
This study found that adjuvant chemotherapy improved OS but not BCSS in T1N0TNBC patients. T1mic patients receiving chemotherapy did not improve OS but decreased BCSS, T1a and T1b patients adjuvant chemotherapy improved OS but not BCSS. >65 years old T1a, > 75 years old T1b and > 80 years old Tc patients receiving chemotherapy did not improve survival and could be used as a clinical reference for patients exempted from chemotherapy.
Impacts of Education and Perception on Vietnamese High School Students' Behaviors Regarding Plastic Waste : The Mediating Role of Attitude
Authors: Nguyen Hien Thi , Ho Thi Truc Quynh , Hoang Ba Loc , Le Thi Cam Tu 
Published: June 2023

Abstract
This study was conducted to analyze the direct and indirect relationship between education, perception and behaviors towards the plastic waste of high school students in Vietnam. The study uses data from a survey of 573 high school students in Vietnam. A cross-sectional study design and questionnaire survey method were used to collect data. Exploratory factor analysis (EFA), confirmatory factor analysis (CFA), descriptive statistics, reliability test Cronbach's Alpha and structural equation modelling (SEM) was used for statistical analysis. Research results show that: Attitude factors play an mediating role in the relationship between education, perception and behavior towards plastic waste. The findings of this study provide the basis for proposing measures to improve behaviors towards plastic waste for Vietnamese high school students.
“Isolation, screening and quantifying of polyhydroxyalkanoates (PHA) using FTIR analysis”
Authors: Baria Dhritiksha M. , Dodiya Kasim R. , Shaikh Junaid A. , Patel Jaydeep M. , Rana Jay R. , RAVAL VIKRAM HIREN 
Published: June 2023

Abstract
Microorganisms produce copious macromolecules, many of which harbor tremendous biotechnological potential. One such macromolecule is polyhydroxyalkanoates (PHA). It is a key substance formed as inclusion bodies by bacteria to accumulate, and reserve growth materials while confronting various stress conditions. PHA is chosen as an alternative for the production of biodegradable polymers due to their quick degradability under natural environmental conditions. The objectives of this study were to identify prospective PHA-producing bacteria and quantify the PHA production. Among 12 isolates that were isolated along the Tithal region, Gujarat; 4 PHA accumulating isolates were selected and evaluated their potential to accumulate PHB granules within the cells. TS-1, TW-4, TW-9, and TS-16 were able to accumulate 38.94%, 40.0%, 34.61%, and 59.19% PHAs respectively. The bacteria were screened using the Sudan Black B method while for confirmatory screening Nile Red method was carried out. PHA was extracted using the sodium hypochlorite method. Fourier transform-infrared (FTIR) confirmation results of the extracted and crude PHA identified its functional units as CH2, CH3, C-O, C = O, and alkyl halide groups. Research into the development of environmentally friendly biopolymer materials has been sparked by the global reliance on petroleum byproducts for the manufacture of plastics, the lack of disposal space, and growing environmental concerns over non-biodegradable synthetic plastics. In light of this, research has focused on the synthesis of polyhydroxybutyrate (PHB), one of the PHAs that has received the most attention.
First evidence of the Upper Jurassic deposis in the Middle Atlas (Marmoucha syncline, Morocco) and connections to the Tethyan Domain
Authors: Boumir Khadija , Ouarhache Driss , Feist Monique , Oussou Ahmed , Ech-charay Kawtar , Ouaskou Mustapha , Charrière André 
Published: June 2023

Abstract

The Marmoucha syncline is located in the eastern part of the Middle Atlas. In this syncline, the “Gypsum marls” (Bathonian-? Callovian) are covered by red detrital deposits which outcrop in Aït Bazza locality. The upper limit of these detrital deposits is below the transgressional unconformity of the Albian? - Cenomanian marine series. The present work introduces a synthesis of stratigraphical, sedimentological and micropalaeontological studies, which has led to new dating and to the identification of different depositional environments. These results have allowed us to define a new chrono-lithostratigraphic unit, the "Aït Bazza Formation", which comprises three superimposed members (AB1, 2 and 3 Mbs) separated by two sedimentary discontinuities. This formation, exceeding 300m in thickness, is formed by conglomerate, sandstone, sand and varicolored marls. Micropalaeontological bulk sampling in marly horizons revealed associations of charophytes and ostracods, particularly in member 2 (AB2 Mb). The charophytes are represented by oogonia of small Porocharaceae, Clavatoraceae such asGlobator rectispirale,Dictyoclavator ramalhoi, andNodosoclavator bradleyithat characterize the Tithonian. The ostracod microfauna is diverse, consisting of non-marine and lagoonal- shallow marine species at several horizons, associated with sea urchin spines and rare foraminifera, which indicating fluvio-deltaic sedimentary environments subjected to marine influences. This new age contraints of AB2 Mb to the Late Jurassic, and the discovery of marine influences in this eastern part of the folded Middle Atlas, consequently indicates the existence of palaeogeographical connections with the Tethyan domain located to the NE in the Rif foreland.
Risk factors and service gaps affecting a sustainable vocational integration: A qualitative multi-stakeholder analysis in the context of persons with acquired brain injury living in Switzerland
Authors: Karcz Katarzyna , Schiffmann Barbara , Schwegler Urban , Finger Monika E 
Published: June 2023

Abstract
Introduction:
Along with the social and economic challenges posed by an aging society, creating work conditions that allow persons to stay healthy and work into old age has become a major task of Western societies. Retaining employment after returning to work is particularly difficult for individuals with a disability, as evidenced by the high rate of premature labor market dropout. Individuals with acquired brain injury (ABI) exemplify this challenge, as it often impairs cognitive, technical, and interpersonal abilities crucial in today's labor market. To effectively support these individuals, vocational integration practitioners require comprehensive knowledge of risk factors for premature labor market dropout and effective strategies for sustainable work.
Objective
This study aimed to identify perceived risk factors and related service gaps regarding sustainable work for people with ABI, as reported by affected individuals, employers, vocational integration professionals, and health professionals.
Methods
Secondary analysis of data from seven focus group discussions and two interviews with persons with ABI, 15 interviews with employers, and 13 interviews with vocational integration and health professionals. Data were re-examined using thematic analysis.
Results
Two major themes of risk factors were identified: (1) person-related factors (including the subthemes: post-ABI impairments; lack of understanding of post-ABI impairments; poor health management) and (2) environment-related factors (including the subthemes: challenges related to the service structure; insufficient knowledge and education of professionals; challenges at the workplace; difficulties in private life). While stakeholders noted the variety of the currently available services, they particularly pointed to the missing long-term monitoring and counseling services for persons with ABI following the initial return-to-work phase, reflecting a major challenge for sustainable work. An overarching gap related to the fragmentation of the service structure and the lack of case coordination along the working life.
Conclusions
Multiple stakeholders emphasized the importance of empowering individuals, ensuring easy access to professional support, and providing a suitable work environment to address key risk factors and facilitate sustainable work for individuals with ABI. Continuous coaching support, as well as long-term monitoring and counseling following the initial return to work, were identified as potential strategies to achieve these goals.
Bone turnover decreases and bone structure improves during treatment with weekly high-dose methylprednisolone for 12 weeks in Graves’ orbitopathy
Authors: Harsløf Torben , Hikmet Rawan , Ebbehøj Eva , Langdahl Bente 
Published: June 2023

Abstract
Purpose Weekly treatment with the intravenous glucocorticoid methylprednisolone for 12 weeks is mainstay in the treatment of Graves’ orbitopathy but may decrease bone mass and impair bone structure. We therefore investigated bone turnover, -mass and -structure during the treatment cause in these patients.Methods We included 32 patients with Graves’ orbitopathy scheduled for treatment with methylprednisolone. Bone turnover and thyroid function was measured at baseline and after 3, 9, 12, and 24 weeks, bone mineral density was measured using DXA at baseline and after 12 and 24 weeks, and bone structure was measured using HRpQCT at baseline and after 12 weeks.Results Bone turnover and T3 decreased throughout the study. Cortical vBMD at both the radius and tibia increased significantly by 0.98 ± 0.38% (p = 0.01) and 1.35 ± 0.50% (p = 0.01), respectively and cortical porosity at both the radius and tibia decreased significantly by -7.67 ± 3.13% (p = 0.04) and − 3.30 ± 2.17% (p = 0.04), respectively. Bone mineral density was stable during the first 12 weeks but increased significantly by 2.26 ± 3.61% at the femoral neck (p < 0.01) and by 2.24 ± 4.24% at the total hip towards week 24 (p = 0.02).Conclusion During a 12-week course of high-dose intravenous methylprednisolone bone turnover and cortical porosity decreased and during 24 weeks follow up bone mineral density increased. In terms of bone, methylprednisolone therefore is a safe treatment for Graves’ orbitopathy.
Securing and privacy preserving for electronic health records using two-phased scheme
Authors: B Arulmozhi , I Sheeba J. , S Pradeep Devaneyan 
Published: June 2023

Abstract
Patient medical data are stored as Electronic Health Records (EHRs) in the cloud for decentralized clinical access. Information related to a patient’s health, diagnosis, and medication is vital for which individual privacy and security are vital considerations. This article introduces a Two-Phased Privacy Preserving Security Scheme (TP3SS) for EHR stored in clouds. The proposed scheme offers secure access control and attribute-based encryption for privacy-preserving and preventing data falsification. Secure access control is achieved by establishing mutual key-dependent smart contracts between the user, doctors and the EHR storage. The key authentication is provided using record-related attribute encryption that is valid within the contract period. The access and key validity are confined to the smart contract allocated interval by verifying the user identity. Here validity verification and access confinement are pursued using ledge-stored user information. The validation occurs for ensuring the EHR and user attributes are mapped together in the current and previous smart contract access sessions. In the record management process, Hyperledger fabric blockchain is used for preventing internal computation complexities. Similarly, the attribute that is inferred by the Hyperledger fabric blockchain in the current access session is alone used for a key generation; used for accessing and sharing the records. This process prevents the entry of adversary access and improves the security level under controlled complexity.
The Prevalence and Severity of Loneliness and Deficits in Perceived Social Support among people with “Complex Emotional Needs” (CEN): A Systematic Review
Authors: Ikhtabi Sarah , Pitman Alexandra , Maconick Lucy , Pearce Eiluned , Dale Oliver , Rowe Sarah , Johnson Sonia 
Published: June 2023

Abstract
Background
Loneliness and struggles with unmet social needs are a common experience among people with “Complex Emotional Needs” (CEN) who may be diagnosed with a ‘personality disorder’. Given the adverse effects of loneliness and poor perceived social support on physical and mental health, and the importance of a sense of belonging for recovery, a systematic review examining the prevalence/severity of loneliness and deficits in perceived social support among people with CEN is an essential step towards developing an intervention targeting the social needs of people with CEN.
Method
We conducted a systematic review synthesising quantitative data on the prevalence and severity of loneliness and deficits of perceived social support among people with CEN in comparison with other clinical groups and the general population. We searched Medline, Embase, PsycINFO, Web of Social Science, Google scholar and Ethos British Library from inception to December 2021. We conducted quality appraisals using the Joanna Briggs Critical appraisal tools and rated the certainty of evidence using the Grading of Recommendation, Assessment, Development and Evaluation approach. A narrative synthesis was used describing the direction and strength of associations prioritising high quality studies.
Findings
A final set of 70 studies are included in this review, most of which are cross-sectional studies (n=55), based in the United States (51%) and focused on community samples. Our review of evidence found that, across all types of ‘personality disorders’ (except ‘narcissistic personality’ traits), people with traits associated with ‘personality disorder’ or meeting criteria for a diagnosis of ‘personality disorder’, have higher levels of loneliness, low perceived relationship satisfaction, and poor social support compared to the general population and to other clinical samples such as people with depression or psychosis. The evidence also indicated that loneliness could play a role in exacerbating specific symptoms associated with CEN, such as self-harm, identity disturbances, and hallucinations.
Conclusion
The quality of evidence is judged as low quality. However, the adverse effects of loneliness on CEN symptoms and recovery suggests a need to co-develop psychosocial interventions targeting the social needs of people with CEN to improve quality of life and recovery outcomes.
A New Line tunneling SiGe/Si iTFET with Control gate for Leakage Suppression and Subthreshold Swing Improvement
Authors: Lin Jyi-Tsong , Weng Shao-Cheng 
Published: June 2023

Abstract
This article presents a new line tunneling dominating metal-semiconductor contact-induced SiGe-Si tunnel field-effect transistor with control gate (CG-Line iTFET). With a structure where two symmetrical control gates at the drain region are given a sufficient negative bias, the overlap of the energy bands at the drain in the OFF-state is effectively suppressed, thus reducing the tunneling probability and significantly decreasing leakage current. Additionally, the large overlap area between the source and gate improves the gate’s ability to control the tunneling interface effectively, improving the ON-state current and subthreshold swing characteristics. By using the Schottky contact characteristics of a metal-semiconductor contact with different work functions to form a PN junction, the need to control doping profiles or random doping fluctuations is avoided. Furthermore, as ion implantation is not required, issues related to subsequent annealing are also eliminated, which greatly reducing thermal budget. Due to the different material bandgap characteristics selected for the source and drain regions, the probability of overlap of the energy bands in the source region in the ON-state is increased and that in the drain region in the OFF-state is reduced. Based on the feasibility of the actual fabrication process and through rigorous 2D simulation studies, improvements in subthreshold swing and high on/off current ratio can be achieved simultaneously based on the proposed device structure. Additionally, the presence of the control gate structure effectively suppresses leakage current, further enhancing its potential for low power consumption applications.
Optimization of a therapeutic laser accelerated proton beam at 94.8 MeV for Stereotactic Radiosurgery
Authors: Omari Husam Y. Al , Yahia Mohamed E. , Almomani Ali M. , Metwally Walid A. , Al-Omari Balqees Y. 
Published: June 2023

Abstract
Recent advances in laser-accelerated proton technology have unveiled potential applications for Stereotactic Radiosurgery. In this study, we present a beamline simulation designed by TraceWin and SRIM codes to optimize the spectral and spatial properties of a laser-driven proton beam. The simulation incorporates four quadrupoles for beam focusing, an energy selection aperture aided by a cylindrical on-axis absorber, a scatterer, and an angular selection aperture for energy smoothing and collimation. By optimizing the beamline configuration, we have achieved a uniform beam with dose rates surpassing even those utilized in FLASH radiotherapy, allowing the delivery of high doses to millimeter-scale volumes within nanosecond timescales. To validate the efficacy of our beamline for therapeutic applications of radiosurgery, we conducted another comprehensive simulation study on the irradiation of a hypothetical tumor in a head phantom using Geant4 and FLUKA Monte Carlo-based codes. The results demonstrate that the downstream protons exhibit a narrow energy spread of 94.8 ± 3.9 MeV and a homogenized lateral profile with a possible proton dose of 0.022 J/kg at the center of the tumor. The study also included the Boron dose enhancement and secondary radiation environment. By leveraging laser-accelerated protons instead of cyclotrons, our unique platform offers a precise and relatively cost-effective infrastructure for a laser-accelerated proton beam Stereotactic Radiosurgery.
Unlocking the Green Solution: Synergistic Effects of Progesterone and Brassinosteroids in Enhancing Progesterone Phytoremediation and Antioxidant Capacity of Solanum nigrum L.
Authors: Pinto Ana , Silva Daniela Correia da , Cardoso Ana , Fernandes Fátima , Soares Cristiano , Valentão Patrícia , Fidalgo Fernanda , Teixeira Jorge 
Published: June 2023

Abstract

Aims
Progesterone (PROG) has been detected in various concentrations in the environment, with adverse effects on humans and wildlife. So, approaches for reducing the accumulation of this steroid in the environment must be studied. This work aimed at evaluating the phytoremediation potential of PROG by Solanum nigrum L. plants and to understand if 2,4 epibrassinolide (24-EBL) could enhance this species’ tolerance or remediation capacities.
Methods
Three treatments were assembled: 1) control; 2) plants grown in the presence of 0.8 µM PROG; and 3) plants that grew in the presence of 0.8 µM PROG were pre-treated with a foliar application of 10 µM 2,4-EBL (PROG/24 EBL). PROG levels in the nutrient solution, and several antioxidant-related biochemical and molecular endpoints in roots and shoots, were evaluated after 20 days of treatment.
Results
HPLC-DAD analysis showed that no PROG was detected in the nutrient solution after 20 days of treatment. Lipid peroxidation significantly decreased in response to PROG in shoots and roots and the pretreatment with 24 EBL was even more effective for both organs. Also, a decrease in H2O2 levels was observed in both treatments for shoots and roots. Plus, the exogenous application of both steroid hormones increased the plants’ antioxidant system both at the biochemical and gene expression levels.
Conclusions
These results show that S. nigrum can rapidly phytoremediate PROG per se with no negative effects to its growth and that the use of 24 EBL synergistically decreases oxidative damage and enhances the PROG removal ability of the plants.
Takayasu Arteritis and Hyperthyroidism ——A secondary hypertension case report
Authors: He Lian-Man , Liu Min , Dong Wen-yong , Sun Xiao-lin 
Published: June 2023

Abstract
Background: Renovascular disease and hyperthyroidism are secondary hypertension. Takayasu's arteritis (TAK) is a chronic, progressive, non-specific great vasculitis involving the aorta and its major branches. It is one of the causes of renal artery stenosis. Hyperthyroidismis an endocrine disease caused by improper continuous synthesis and secretion of excessive thyroid hormone by the thyroid gland. Both diseases can raise blood pressure.
Case presentation: we present a case of 18-year-old. Female, After exercise, fatigue palpitations. The maximum blood pressure(BP) was 190/87 mmHg, ankle-brachial index (ABI )was less than 0.9. C-reactive protein (CRP)and erythrocyte sedimentation rate (ESR)were elevated. Imaging revealed Multiple vascular stenosis. T3,T4, FT3,FT4,TPO-Ab and TR-Ab were elevated. TSH reduced. she was diagnosed with Takayasu arteritis and hyperthyroidism. After treatment, the blood pressure was normal, the thyroid function gradually returned to normal, and the symptoms improved.
Conclusion: It is suggested that the blood pressure of both upper limbs should be measured in newly diagnostic hypertension, Few cases of Takayasu arteritis complicated with hyperthyroidism have been reported. Both diseases are related to the immune system, whether there is any correlation between the two diseases, further research is needed. Early diagnosis, early treatment, the earlier intervention, the better prognosis.