bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tuning Electrochemical Properties of Nitroaromatic Cathodes by Function‐Oriented Design for Rechargeable Lithium‐Ion Batteries
Authors: Liu Xudong , Wang Xinling , Ye Zhibin 
Published: April 2023

AbstractRechargeable lithium‐ion batteries (LIBs) based on organic cathodes are an attractive alternative energy storage technology owing to the low cost and sustainability. Recently, nitro functionality in dinitrobenzenes is successfully demonstrated as an electrochemically reversible high‐capacity redox group. In this study, a function‐oriented design is employed to further disclose the effects of substituting functional groups and molecular conjugate structures on electrochemical properties of a range of nitroaromatic derivatives as organic cathodes for rechargeable LIBs. In specific, it is revealed that the redox potential of nitroaromatic cathodes can be effectively adjusted by introducing distinct electronically inducible functional groups, while the cyclic life can be significantly prolonged with the introduction of the hydrophilic groups. When constructed with extended π‐conjugated structures, the electronic conductivity and electrochemical kinetics of nitroaromatics are increased significantly owing to their various long‐range π–π stacking. Moreover, density‐functional theory calculations further provide theoretical insights into the distinct electrochemical behaviors of the various nitroaromatics in the molecular level. This is the first study that reveals the influences of substituting groups and conjugated structures on the electrochemical performance of nitroaromatic cathode materials, which enables a function‐oriented molecular design of such organic materials and sheds light on their future development.
A Flexible and Safe Planar Zinc‐Ion Micro‐Battery with Ultrahigh Energy Density Enabled by Interfacial Engineering for Wearable Sensing Systems
Authors: Cai Xinze , Liu Ying , Zha Jiajia , Tan Feipeng , Zhang Bingyao , Yan Weibin , Zhao Jiangqi , Lu Bingan , Zhou Jiang , Tan Chaoliang 
Published: April 2023

AbstractAqueous zinc‐ion micro‐batteries (ZIMBs) have attracted considerable attention owing to their reliable safety, low cost, and great potential for wearable devices. However, current ZIMBs still suffer from various critical issues, including short cycle life, poor mechanical stability, and inadequate energy density. Herein, the fabrication of flexible planar ZIMBs with ultrahigh energy density by interfacial engineering in the screen‐printing process based on high‐performance MnO2‐based cathode materials is reported. The Ce‐doped MnO2 (Ce‐MnO2) exhibits significantly enhanced capacity (389.3 mAh g−1), considerable rate capability and admirable cycling stability than that of the pure MnO2. Importantly, the fabrication of micro‐electrodes with ultrahigh mass loading of Ce‐MnO2 (24.12 mg cm−2) and good mechanical stability is achieved through optimizing the interfacial bonding between different printed layers. The fabricated planar ZIMBs achieve a record high capacity (7.21 mAh cm−2 or 497.31 mAh cm−3) and energy density (8.43 mWh cm−2 or 573.45 mWh cm−3), as well as excellent flexibility. Besides, a wearable self‐powered sensing system for environmental monitoring is further demonstrated by integrating the planar ZIMBs with flexible solar cells and a multifunctional sensor array. This work sheds light on the development of high‐performance planar ZIMBs for future self‐powered and eco‐friendly smart wearable electronics.
Dual‐Defect Manipulation Enables Efficient and Spectrally Stable Blue Perovskite Light‐Emitting Diodes
Authors: Zhang Chengxi , Yuan Hao , Kong Lingmei , Wang Lin , Wang Yuanzhi , Li Yunguo , Yang Yingguo , Turyanska Lyudmila , Yang Xuyong 
Published: April 2023

AbstractPerformance of blue solution‐processed perovskite light‐emitting diodes (LEDs) is limited by availability of blue perovskite materials. Herein, 4‐(trifluoromethyl)benzoyl ammonium bromide (4‐TMBABr) is used with abundant NH and CO groups to passivate the defects and produce highly stable PEAxPA2‐x(CsPbBr3)n‐1PbBr4 perovskites for blue LED applications. The NH group in the 4‐TMBABr suppresses the Br‐ion mismatch through hydrogen bonds (N‐H···Br) and CO group coordinates the unsaturated lead dangling bonds (CO:Pb). The effective defect passivation by 4‐TMBABr reduces the nonradiative recombination in the perovskite films, hence enhancing its optical performance. In the LED structure, the sodium bis(trifluoromethanesulfonyl)imide (SBTI) modified NiOx films are used to improve the hole transport and to inhibit the fluorescence quenching of the perovskite layer. The dual‐defect manipulation strategy is advantageous for producing efficient and spectrally stable blue perovskite LEDs, and the authors demonstrate an LED with maximum luminance of 1094 cd m−2 and external quantum efficiency of 10.3%. This work can inform and underpin future development of blue perovskite LEDs with highly efficient and stabile performance.
White Matter Changes after Neurobehavioral Therapy for Functional Seizures
Authors: Mueller Christina , Goodman Adam M. , Allendorfer Jane B. , Nenert Rodolphe , Gaston Tyler E. , Grayson Leslie E. , Correia Stephen , Philip Noah S. , LaFrance W. Curt , Szaflarski Jerzy P. 
Published: April 2023

ObjectiveWe aimed to prospectively quantify changes in white matter morphology after neurobehavioral therapy (NBT) for functional seizures (FS) using neurite orientation dispersion and density imaging (NODDI). We hypothesized that patients with FS would exhibit white matter plasticity in the uncinate fasciculus, fornix/stria terminalis, cingulum, and corticospinal tract following NBT that would correlate with improvements in affective symptoms, postconcussive symptoms, and quality of life (QOL).MethodsForty‐two patients with traumatic brain injury (TBI) and FS (TBI+FS) underwent NBT and provided pre−/postintervention neuroimaging and behavioral data; 47 controls with TBI without FS (TBI‐only) completed the same measures but did not receive NBT. Changes in neurite density, orientation dispersion (orientation dispersion index [ODI]), and extracellular free water (FW) were compared between groups.ResultsSignificant ODI increases in the left uncinate fasciculus in TBI+FS (mean difference = 0.017, p = 0.039) correlated with improvements in posttraumatic symptoms (r = −0.395, p = 0.013), QOL (r = 0.474, p = 0.002), emotional well‐being (r = 0.524, p < 0.001), and energy (r = 0.474, p = 0.002). In TBI‐only, ODI decreased (mean difference = −0.008, p = 0.047) and FW increased (mean difference = 0.011, p = 0.003) in the right cingulum. FW increases correlated with increased psychological problems (r = 0.383, p = 0.013). In TBI+FS, NBT resulted in FS decreases of 3.5 seizures per week. None of the imaging changes correlated with FS frequency.InterpretationWe identified white matter changes after NBT in patients with FS that were associated with improved psychosocial functioning. NODDI could be incorporated into future mechanistic assessments of interventions in patients with FS. ANN NEUROL 2023;94:350–365
Ultrathin Niobium Carbide MXenzyme for Remedying Hypertension by Antioxidative and Neuroprotective Actions
Authors: Yang Hui , Xia Lili , Ye Xuanxuan , Xu Jiayi , Liu Tianfeng , Wang Linping , Zhang Shuai , Feng Wei , Du Dongshu , Chen Yu 
Published: April 2023

AbstractHypertension, as a leading risk factor for cardiovascular diseases, is associated with oxidative stress and impairment of endogenous antioxidant mechanisms, but there is still a tremendous knowledge gap between hypertension treatment and nanomedicines. Herein, we report a specific nanozyme based on ultrathin two‐dimensional (2D) niobium carbide (Nb2C) MXene, termed Nb2C MXenzyme, to fight against hypertension by achieving highly efficient reactive oxygen species elimination and inflammatory factors inhibition. The biocompatible Nb2C MXenzyme displays multiple enzyme‐mimicking activities, involving superoxide dismutase, catalase, glutathione peroxidase, and peroxidase, inducing cytoprotective effects by resisting oxidative stress, thereby alleviating inflammatory response and reducing blood pressure, which is systematically demonstrated in a stress‐induced hypertension rat model. This strategy not only opens new opportunities for nanozymes to treat hypertension but also expands the potential biomedical applications of 2D MXene nanosystems.
Total Syntheses of Polyhydroxylated Steroids by an Unsaturation‐Functionalization Strategy
Authors: Sun Jiawei , Chen Yuan , Ragab Sherif Shaban , Gu Wei , Tang Ziqiang , Tang Yuexun , Tang Wenjun 
Published: April 2023

AbstractHighly oxygenated cardiotonic steroids, such as ouabain, possess a wide spectrum of biological functions and remain significant synthetic challenges. Herein, we have applied an unsaturation‐functionalization strategy and developed a synthetic method in addressing the C19‐hydroxylation issue for efficient synthesis of polyhydroxylated steroids. An effective asymmetric dearomative cyclization allowed the construction of the C19‐hydroxy unsaturated steroidal skeleton in only four steps from the Hajos‐Parrish ketone ketal 7. The synthetic sequence featured C3−OH‐directed hydrogenation/epoxidation, m‐CPBA‐triggered epoxidation/SN2′ nucleophilic substitution, Birch reduction of an enone, and regioselective LiAlH4 reduction to furnish the polyhydroxy functionalities on the steroid skeleton with high stereochemical control and efficiency. This approach ultimately enabled the total synthesis of 19‐hydroxysarmentogenin and ouabagenin in 18 and 19 steps, respectively, overall. The synthesis of these polyhydroxylated steroids offers synthetic versatility and practicality in the search for new therapeutic agents.
Carboxylation of Acetylene without Salt Waste: Green Synthesis of C4 Chemicals Enabled by a CO2‐Pressure Induced Acidity Switch
Authors: van Lingen Tim , Bragoni Valentina , Dyga Marco , Exner Benjamin , Schick Daniel , Held Christoph , Sadowski Gabriele , Gooßen Lukas J. 
Published: April 2023

AbstractThe inherent formation of salt waste in C−H carboxylations is a key obstacle precluding the utilization of CO2 as C1 building block in the industrial synthesis of base chemicals. This challenge is addressed in a circular process for the production of the C4 base chemical dimethyl succinate from CO2 and acetylene. At moderate CO2 pressures, acetylene is doubly carboxylated in the presence of cesium carbonate. Hydrogenation of the C−C triple bond stabilizes the product against decarboxylation. By increasing the CO2 pressure to 70 bar, the medium is reversibly acidified, allowing an esterification of the succinate salt with methanol. The cesium base and the hydrogenation catalyst are regenerated and can be reused. This provides the proof of concept for a salt‐free route to C4 chemicals from biogas (CH4/CO2). The origin of this reversible acidity switch and the critical roles of the cesium base and the NMP/MeOH solvents were elucidated by thermodynamic modeling.
Improvement of Antibody Activity by Controlling Its Dynamics Using the Glycan–Lectin Interaction
Authors: Manabe Yoshiyuki , Iizuka Yuki , Yamamoto Ryuku , Ito Keita , Hatano Kanae , Kabayama Kazuya , Fukase Koichi 
Published: April 2023

AbstractAntibody dynamics on membranes, such as endocytosis and clustering, are vital in determining antibody functions. In this study, we demonstrated that glycan conjugation can modulate antibody dynamics through the glycan–lectin interaction to regulate its potency. The anti‐HER2 antibody, an anti‐breast‐cancer antibody, was conjugated with galactose‐containing N‐glycan, and its internalization was suppressed by interaction with galectin‐3, leading to enhanced complement‐dependent cytotoxic (CDC) activity. This glycan–antibody conjugate is proposed as a new approach to modulate antibody activity and may provide an alternative strategy for redeveloping antibody drugs that do not exhibit sufficient activity.
Drivers of behaviour and spatial ecology of the small spotted catshark (Scyliorhinus canicula)
Authors: Papadopoulo Kenn , Villegas‐Ríos David , Mucientes Gonzalo , Hillinger Alina , Alonso‐Fernández Alexandre 
Published: April 2023

Abstract

Shark populations have suffered dramatic declines across the world as a result of overfishing.
Marine protected areas (MPAs) can help restore overfished populations; however, their effectiveness largely relies on understanding the ecology of the targeted species.
This study investigated the spatial ecology of the intensely harvested but understudied small spotted catshark (Scyliorhinus canicula) through acoustic telemetry in the Cíes Islands, a small MPA in the north‐west of the Iberian Peninsula.
There were significant effects of diel, seasonal cycles, biotic (sex and total length) and abiotic (bottom sea temperature) variables on the spatial behaviour of S. canicula. The mean residency index was low (0.27) and movement patterns suggested a strong connection with inshore waters. While the probability of presence in the study area was mainly driven by sex (i.e. greater for females), a drastic increase in activity was observed at night (compared with daytime hours). The activity space decreased with larger body sizes. Warmer waters were related to higher activity levels and larger activity spaces.
This study provides essential knowledge of the spatial behaviour of S. canicula, with significant implications for the conservation and management of this species. The results indicate that small MPAs may fail to protect the whole range of movements of S. canicula, but suggest a larger protection potential for females.
To be effective for S. canicula conservation, MPAs should be appropriately sized and designed for the ranging behaviour of the target species in order to provide total protection. Temporal restrictions on fishing at night mirroring the peak activity pattern of S. canicula could be implemented to limit the probability of its capture.
Chemical Sensors using Single‐Molecule Electrical Measurements
Authors: Sun Ruiqin , Lv Jieyao , Xue Xinyi , Yu Shiyong , Tan Zhibing 
Published: April 2023

AbstractDriven by the digitization and informatization of contemporary society, electrical sensors are developing toward minimal structure, intelligent function, and high detection resolution. Single‐molecule electrical measurement techniques have been proven to be capable of label‐free molecular recognition and detection, which opens a new strategy for the design of efficient single‐molecule detection sensors. In this review, we outline the main advances and potentials of single‐molecule electronics for qualitative identification and recognition assays at the single‐molecule level. Strategies for single‐molecule electro‐sensing and its main applications are reviewed, mainly in the detection of ions, small molecules, oligomers, genetic materials, and proteins. This review summarizes the remaining challenges in the current development of single‐molecule electrical sensing and presents some potential perspectives for this field.
Use of monoclonal antibody therapy in hematologic patients with mild‐to‐moderate COVID‐19: A retrospective single‐center experience
Authors: Amanam Idoroenyi , Yao Janny , Puing Alfredo , Tsai Ni‐Chun , Samuels Diana , Ngo Dat , Ho Stephanie , Ali Haris , Aribi Ahmed , Arslan Shukaib , Artz Andrew , Htut Myo , Koller Paul , Salhotra Amandeep , Sandhu Karamjeet , Nikolaenko Liana , Pawlowska Anna , Shouse Geoffrey , Stein Anthony , Marcucci Guido , Forman Stephen , Nakamura Ryotaro , Dadwal Sanjeet , Al Malki Monzr M. 
Published: April 2023

AbstractIntroductionIn November 2020, the FDA issued an emergency use authorization (EUA) for monoclonal antibody (mAb) therapy in patients with mild‐to‐moderate COVID‐19 at high risk for disease progression.MethodsWe retrospectively reviewed 38 adult hematology patients who received mAbs from 11/2020 to 2/2021.ResultsThirty (79%) patients received bamlanivimab and 8 (21%) casirivimab‐imdevimab. Four (11%) patients were hospitalized due to COVID‐19, two (5%) progressed to severe disease and one patient (3%) died within 30 days from COVID‐19 disease. Most patients (n = 34, 89%) ultimately tested negative for SARS‐CoV‐2, with 34% (n = 13) clearing the virus within 14 days after mAb infusion. The median time to clearance of viral shedding was 25.5 days (range: 7–138). After mAb infusion, most patients with hematological malignancies (HM) (n = 10/15; 67%) resumed therapy for underlying disease with a median delay of 21.5 days (range: 12–42). We observed a significant difference in hospitalization among patients who received a HCT versus non‐HCT (0% n = 0/26 and 36% n = 4/11, respectively; p < 0.01).ConclusionsThis study demonstrates that SARS‐CoV‐2 specific mAb was safe and may reduce hospitalization compared to what is reported in malignant hematology patients at high risk for disease progression. Our HCT cohort patients had less hospitalization rate compared with HM cohort patients.
Landscape of gene mutation in Chinese thyroid cancer patients: Construction and validation of lymph node metastasis prediction model based on clinical features and gene mutation marker
Authors: Wei Meng , Wang Rui , Zhang Wanxue , Zhang Jing , Fang Qiang , Fang Zheng , Liu Bin , Li Yongxiang 
Published: April 2023

AbstractObjectivesReporting the clinicopathological information of thyroid cancer (TC) patients from a central medical center of east China, and constructing the nomogram predicting lymph node metastasis (LNM).MethodsWe collected the patients who underwent thyroid cancer surgery in our institute from July 1, 2019 to July 31, 2021, a total of 253 subjects were enrolled. We used HiPure FFPE DNA Kit to extract DNA and RNApure FFPE Kit to extract RNA from the paraffin sections of tumor tissue, the extracted DNA samples and RNA samples were used for NGS sequencing. The clinical and pathological information of TCGA‐THCA cohort was obtained as the validation cohort. Multivariate logistic regression analysis was performed to identify the independent prognostic factor, and the nomogram was subsequently constructed by “rms” R package.ResultsSecondary cases contained more mutation of BRAF (90.48% vs. 62.07%) and TERT (33.0% vs. 3.0%), as compared with primary cases. Primary patients with positive lymph node were younger (40.9 ± 10.8 vs. 45.3 ± 11.8, p = 0.0031) and contained advanced TI‐RADS levels (4c: 22.8% vs. 8.3%, 5: 6.5% vs. 0/0%, p = 1.878e‐03), as well as more RET genetic alteration (16.3% vs. 2.7%, p = 2.566e‐03). We chose age, tumor diameter, RET fusion, and gender to construct the LNM predicting nomogram. Calibration plot, DCA curve, and the clinical impact plot verified the preferable prognostic value of the nomogram, with an AUC value of 0.724 (0.656–0.792). We successfully validated the prognostic value of the nomogram in TCGA‐THCA cohort. RET fusion might impact the process of protein digestion and absorption, cytokine‐cytokine receptor interaction, ECM‐receptor interaction, focal adhesion.ConclusionWe provide a novel nomogram to predict the LNM for TC patients, including the features of patient's age, gender, tumor diameter, and RET alteration. Further studies from multiple medical centers are essential to validate the nomogram.
Disulphide Cross‐Linked Ultrashort Peptide Hydrogelator for Water Remediation
Authors: Kanti Das Basab , Samanta Raju , Ahmed Sahnawaz , Pramanik Bapan 
Published: April 2023

AbstractA single amino acid in a peptide sequence can play an important role to tune the self‐assembly and hydrogelation behaviour. Here, a C‐terminal cysteine‐containing ultrashort peptide hydrogelator forms hydrogel through non‐covalent and covalent interactions. Interestingly, the hydrogel is insoluble in water and buffer solutions at different pH values (1‐13) and is thixotropic and injectable. In recent years, removing dyes from contaminated water has become a significant concern because of the shortage of freshwater resources. Therefore, the adsorption of dyes through a reliable, straightforward, nontoxic, cheap, and environmentally friendly adsorbent has become a popular topic. Hence, the hydrogelator was exploited to remove organic dyes from wastewater, harnessing its applicability in the gel phase and solid supports (filter paper and cotton).
Metastatic adult‐type non‐rhabdomyosarcoma soft tissue sarcomas in children and adolescents: A cohort study from the European paediatric Soft tissue sarcoma Study Group
Authors: Ferrari Andrea , Orbach Daniel , Casanova Michela , van Noesel Max M. , Berlanga Pablo , Brennan Bernadette , Corradini Nadege , Schoot Reineke A. , Ramirez‐Villar Gema L. , Hjalgrim Lisa Lyngsie , Alaggio Rita , Guillen Burrieza Gabriela , Safwat Akmal , Cameron Alison L. , van Rijn Rick R. , Minard‐Colin Veronique , Zanetti Ilaria , Bisogno Gianni , Chisholm Julia C. , Merks Johannes H. M. 
Published: April 2023

AbstractBackgroundLimited data exist on the clinical behavior of pediatric non‐rhabdomyosarcoma soft tissue sarcomas (NRSTS) with distant metastases at onset, and a clear standard of care has not yet been defined.MethodsThis cohort study reports on pediatric adult‐type metastatic NRSTS enrolled in two concurrent prospective European studies, i.e., the randomized BERNIE study and the single‐arm MTS 2008 study developed by the European paediatric Soft tissue sarcoma Study Group. Treatment programs were originally designed for patients with metastatic rhabdomyosarcoma, i.e., nine courses of multidrug chemotherapy (with or without bevacizumab in the BERNIE study), followed by 12 cycles of maintenance therapy, whereas radiotherapy and/or surgery (on primary tumor and/or metastases) were delayed until after seven courses of chemotherapy had been administered.ResultsThe study included 61 patients <21 years old treated from July 2008 to December 2016. The lung was the site of metastases in 75% of the cases. All patients received multi‐agent chemotherapy, 44% had local therapy to primary tumor, and 18% had treatment of metastases. Median time to progression/relapse was 6 months. A high rate of tumor progression was observed during the initial part of the chemotherapy program. With a median follow‐up of 41.5 months (range, 2–111 months), 3‐year event‐free survival and overall survival were 15.4% (95% confidence interval [CI], 7.6–25.7) and 34.9% (95% CI, 22.7–47.5), respectively. There were no statistically significant differences in outcome depending on the type of treatment administered.ConclusionsThe study confirmed the overall poor outcome for patients with metastatic NRSTS, whose treatment remains a challenge.Plain Language Summary

Pediatric non‐rhabdomyosarcoma soft tissue sarcomas form a heterogeneous group of rare tumors.
Although recent international studies have defined the standard of care for patients with localized disease, limited data are available on the clinical behavior of patients with distant metastases.
This study on 61 metastatic cases treated on two prospective European protocols confirms that the chances of survival of such patients are often dismal and a standard treatment is still lacking.