bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of Semaglutide on Albuminuria and Kidney Function in People With Overweight or Obesity With or Without Type 2 Diabetes: Exploratory Analysis From the STEP 1, 2, and 3 Trials
Authors: Heerspink Hiddo J.L. , Apperloo Ellen , Davies Melanie , Dicker Dror , Kandler Kristian , Rosenstock Julio , Sørrig Rasmus , Lawson Jack , Zeuthen Niels , Cherney David 
Published: February 2023

<p> </p>
<p><strong>INTRODUCTION</strong></p>
<p>These post hoc analyses of the STEP 1–3 trials (NCT03548935, NCT03552757, NCT03611582) explored the effects of semaglutide (up to 2.4mg) on kidney function.</p>
<p><strong>RESEARCH DESIGN AND METHODS</strong></p>
<p>STEP 1–3 included adults with overweight/obesity; STEP 2 patients also had type 2 diabetes. Participants received once-weekly subcutaneous semaglutide 1.0mg (STEP 2 only), 2.4mg, or placebo for 68 weeks, plus lifestyle intervention (STEP 1 and 2) or intensive behavioral therapy (STEP 3). Changes in urine albumin-to-creatinine ratio (UACR) and UACR status from baseline to week 68 were assessed for STEP 2. Changes in estimated glomerular filtration rate (eGFR) were assessed from pooled STEP 1–3 data.</p>
<p><strong>RESULTS</strong></p>
<p>In STEP 2, 1,205 (99.6% total cohort) patients had UACR data; geometric mean baseline UACR was 13.7, 12.5, and 13.2 mg/g with semaglutide 1.0mg, 2.4mg, and placebo, respectively. At week 68, UACR changes were –14.8% and –20.6% with semaglutide 1.0 and 2.4mg, respectively, and +18.3% with placebo (between-group differences [95% confidence interval] vs. placebo: −28.0% [−37.3, −17.3], <em>P</em><0.0001 semaglutide 1.0mg; −32.9% [−41.6, −23.0], <em>P</em>=0.003 semaglutide 2.4mg). UACR status improved in greater proportions of patients with semaglutide 1.0 and 2.4mg versus placebo (<em>P</em>=0.0004 and <em>P</em>=0.0014, respectively). In the pooled STEP 1–3 analyses, 3,379 participants had eGFR data; there was no difference between semaglutide 2.4mg and placebo in eGFR trajectories at week 68.</p>
<p><strong>CONCLUSION</strong></p>
<p>Semaglutide improved UACR in adults with overweight/ obesity and type 2 diabetes. In participants with normal kidney function, semaglutide did not have an effect on eGFR decline.</p>
Initiation of continuous glucose monitoring is linked with improved glycemic control and reduced clinical events in type 1 and type 2 diabetes in the Veterans Health Administration
Authors: Reaven Peter D. , Newell Michelle , Rivas Salvador , Zhou Xinkai , Norman Gregory J. , Zhou Jin J. 
Published: February 2023

<p> </p>
<p><strong>Objective: </strong>To determine the benefit of starting continuous glucose monitoring (CGM) in adult-onset type 1 diabetes and type 2 diabetes (T1D; T2D) on longer-term glucose control and serious clinical events.</p>
<p><strong>Research Design and Methods: </strong>A retrospective observational cohort study within the VA Health Care System was used to compare glucose control, and hypoglycemia and hyperglycemia related admissions to emergency rooms or hospitals and all-cause hospitalization between propensity score weighted initiators of CGM and non-CGM users over 12-months. </p>
<p><strong>Results: </strong>5,015 T1D and 15,706 T2D CGM users receiving insulin and similar numbers of non-CGM users were identified from 1/1/2015-12/31/2020. Declines in HbA1c were significantly greater in T1D CGM users (-0.26%,CI:-0.33%,-0.19%) and T2D CGM users (-0.35%,CI:-0.40%, -0.31%) than in non-users at 12 months. Percentages of patients achieving HbA1c < 8% and < 9% after 12 months were greater in CGM users. </p>
<p>In T1D, CGM initiation was associated with significantly reduced risk for hypoglycemia (HR: 0.69,CI:0.48-0.98) and all-cause hospitalization (HR 0.75, CI:0.63-0.90). In T2D patients, there was a reduction in risk for hyperglycemia in CGM users (HR 0.87, CI:0.77-0.99) and all-cause hospitalizations (HR 0.89, CI:0.83-0.97). Several subgroups (based on baseline age, HbA1c, hypoglycemic risk or follow-up CGM use) had even greater responses.</p>
<p><strong>Conclusion: </strong>In a large national cohort, initiation of CGM was associated with sustained improvements in HbA1c in later-onset T1D patients and T2D patients using insulin. This was accompanied by a clear pattern of reduced risk for admissions to emergency rooms or hospitals for hypoglycemia or hyperglycemia and for all-cause hospitalization. </p>
A National Physician Survey of Deintensifying Diabetes Medications for Older Adults with Type 2 Diabetes
Authors: Pilla Scott J. , Jalalzai Rabia , Tang Olive , Schoenborn Nancy L. , Boyd Cynthia M. , Golden Sherita H. , Mathioudakis Nestoras N , M. Maruthur Nisa 
Published: February 2023

<p> </p>
<p><strong>Objective:</strong> Determine physicians’ approach to deintensifying (reducing/stopping), or switching hypoglycemia-causing medications for older adults with type 2 diabetes.</p>
<p><strong>Research Design and Methods: </strong>In this national survey, U.S. physicians in general medicine, geriatrics, or endocrinology reported changes they would make to hypoglycemia-causing medications for older adults in three scenarios: good health, HbA1c 6.3%; complex health, HbA1c 7.3%; poor health, HbA1c of 7.7%.</p>
<p><strong>Results:</strong> There were 445 eligible respondents (response rate 37.5%). In patient scenarios, 48%, 4%, and 20% of physicians deintensified hypoglycemia-causing medications for patients with good, complex, and poor health, respectively. Overall, 17% of physicians switched medications without significant differences by patient health. Half of physicians selected HbA1c targets below guidelines for older adults with complex or poor health.</p>
<p><strong>Conclusion: </strong>Most U.S. physicians would not deintensify or switch hypoglycemia-causing medications within guideline-recommended HbA1c targets. Physicians’ preference for lower HbA1c targets than guidelines needs to be addressed to optimize deintensification decisions.</p>
Respons pertumbuhan rimpang Jahe Merah (Zingiber officinale Var. Rubrum) pada perendaman auksin dan PGPR (Plant Growth Promoting Rhizobacteria)
Authors: Wardana Singgih Tri , Juswardi Juswardi , Rama Nanda Lian Ade 
Published: February 2023

Jahe merah (Zingiber officinale Var. Rubrum) merupakan tanaman yang memiliki manfaat sebagai bahan obat herbal pencegahan COVID-19. Salah satu kendala dalam budidaya jahe merah terdapat pada masa dormansi jahe merah yaitu selama 2-4 minggu. Masa dormansi jahe merah yang panjang menyebabkan penurunan hasil produksi rimpang jahe merah. Zat pengatur tumbuh auksin dan PGPR (Plant Growth Promoting Rhizobacteria) memiliki fungsi sebagai pemacu pertumbuhan. Rancangan Penelitian yang digunakan Rancangan Acak Lengkap (RAL) dengan 4 perlakuan dan masing masing perlakuan dilakukan 6 kali pengulangan. Variabel pengamatan yaitu persentase rimpang tumbuh tunas, persentase rimpang tumbuh akar, jumlah tunas, jumlah akar, tinggi tunas, panjang akar, waktu muncul tunas dan jumlah daun. Data pertumbuhan rimpang jahe merah dianalisis dengan menggunakan ANOVA (Analysis of Varian). Apabila perlakuan berpengaruh nyata, maka akan dilanjutkan dengan uji lanjut Duncan pada α = 0,05. Hasil dari penelitian ini adalah didapatkan hasil lebih baik pada kombinasi auksin dan PGPR terhadap rata rata jumlah tunas 1,16, rata rata jumlah daun 0,83, waktu muncul tunas yang singkat yaitu 8,00 HST dan rata rata tinggi tunas 4,63 cm. Perendaman auksin lebih baik terhadap rata rata jumlah akar yaitu 1,00 dan rata rata panjang akar 1,68 cm,. Persentase rimpang tumbuh tunas lebih baik pada perendaman auksin dan PGPR yaitu 100%. Persentase rimpang tumbuh akar lebih baik pada perendaman auksin yaitu 83,3%. Kesimpulan penelitian didapatkan kombinasi perendaman auksin dan PGPR memberikan pengaruh lebih baik pada pertumbuhan rimpang jahe merah. Perendaman auksin dan PGPR dapat dilakukan penelitian lebih lanjut dengan konsentrasi auksin lebih tinggi untuk mendapat hasil optimal dalam memacu akar rimpang jahe merah.
Primary spinal intramedullary anaplastic ganglioglioma in a pediatric patient
Authors: Dang Huy , Khan Abdul Basit , Gadgil Nisha , Prablek Marc , Lin Frank Y. , Blessing Melissa M. , Aldave Guillermo , Bauer David 
Published: February 2023

Background:
Gangliogliomas (GGs) are rare tumors of the central nervous system composed of neoplastic neural and glial cells and are typically low-grade. Intramedullary spinal anaplastic GGs (AGG) are rare, poorly understood, and often aggressive tumors that can result in widespread progression along the craniospinal axis. Due to the rarity of these tumors, data are lacking to guide clinical and pathologic diagnosis and standard of care treatment. Here, we present a case of pediatric spinal AGG to provide information on our institutional approach to work-up and to highlight unique molecular pathology.

Case Description:
A 13-year-old female presented with signs of spinal cord compression including right sided hyperreflexia, weakness, and enuresis. Magnetic resonance imaging (MRI) revealed a C3-C5 cystic and solid mass which was treated surgically with osteoplastic laminoplasty and tumor resection. Histopathologic diagnosis was consistent with AGG, and molecular testing identified mutations in H3F3A (K27M), TP53, and NF1. She received adjuvant radiation therapy and her neurological symptoms improved. However, at 6-month follow-up, she developed new symptoms. MRI revealed metastatic recurrence of tumor with leptomeningeal and intracranial spread.

Conclusion:
Primary spinal AGGs are rare tumors, but a growing body of literature shows some trends that may improve diagnosis and management. These tumors generally present in adolescence and early adulthood with motor/sensory impairment and other spinal cord symptoms. They are most commonly treated by surgical resection but frequently recur due to their aggressive nature. Further reports of these primary spinal AGGs along with characterization of their molecular profile will be important in developing more effective treatments.
Chronic epidural hematoma with frontal skull-base destruction mimicking osteogenic tumor, associated with coagulopathy due to chronic hepatitis C
Authors: Nakazato Ichiro , Tanaka Hideki , Oyama Kenichi , Onoda Keisuke , Matsuno Akira 
Published: February 2023

Background:
Intracranial epidural hematoma is generally evoked by acute coup-injury. Though rare, it has a chronic clinical course and can be a non-traumatic event.

Case Description:
The patient was A thirty-five-year-old man with a complaint of one-year history of hand tremor. He was suspected diagnosis of osteogenic tumor with differential diagnosis of epidural tumor, or abscess in the right frontal skull base bone, associated with chronic type C hepatitis because of his plain CT and MRI.

Results:
Results of examinations and surgery, the extradural mass was chronic epidural hematoma without skull fracture. We diagnosis he is the rare case of chronic epidural hematoma caused by coagulopathy due to chronic hepatitis C.

Conclusion:
We reported a rare case of chronic epidural hematoma caused by coagulopathy due to chronic hepatitis C. The repeated spontaneous hemorrhage in the epidural space formed the capsule and destruction of skull base bone, just mimicking skull base tumor.
PHASE COMPLEX OF A FOUR-COMPONENT SYSTEM LiCl–KCl–Li2WO4–PbWO4
Authors: Кочкаров Ж.А. , Байсангурова А.А. , Хасбулатова З.С. 
Published: February 2023

Изучена фазовая диаграмма четырехкомпонентной взаимной системы Li, K, Pb‖Cl, WO4. Проведена триангуляция его фазовой диаграммы на симплексы, выявлены древо кристаллизации и координаты эвтектической точки.
The phase diagram of the four-component reciprocal system Li, K, Pb‖Cl, WO4 has been studied. The triangulation of its phase diagram into simplices is carried out, the crystallization tree and the coordinates of the eutectic point are revealed.
GENERAL ANALYSIS OF THE CRITICAL EFFECTS OF FLOODS ON THE BIOLOGICAL COMPONENTS OF THE ECOSYSTEM OF THE MIDDLE OB
Authors: Болотнов В.П. 
Published: February 2023

В статье приводится анализ критических воздействий половодий на сообщество рыб, луговой растительности, птиц, популяции ондатры, водяной полевки на выделенных участках поймы для выявления зональной изменчивости показателей предельного воздействия половодий. Для выделения критических воздействий используются графики связи показателей устойчивости и индекса воздействия половодий. Полученные характеристики могут использоваться для нормирования изменений половодий и мониторинга пойменных экосистем.
The article analyzes the critical effects of floods on the community of fish, meadow vegetation, birds, muskrat population, water vole in selected areas of the floodplain to identify zonal variability in indicators of the marginal impact of floods. To identify critical impacts, graphs of the relationship between stability indicators and the flood impact index are used. The obtained characteristics can be used to normalize changes in floodplains and monitor floodplain ecosystems.
DEVELOPMENT OF AN ALGORITHM FOR PREDICTIVE ACCOUNTING OF ENERGY RESOURCES FOR THE CALCULATOR OF ENGINEERING SYSTEMS
Authors: Шаповал А.Ф. , Мелехин А.А. 
Published: February 2023

Актуальность темы обусловлена развитием цифровых технологий для решения инженерных задач, в том числе в строительной сфере. В статье представлен алгоритм прогнозного учета энергетических ресурсов для калькуляторов инженерных систем. Этот алгоритм реализован в инженерном калькуляторе вэб-приложения. В качестве реализации алгоритма используется язык программирования DHTML.
The relevance of the topic is due to the development of digital technologies for solving engineering problems, including in the construction sector. The article presents an algorithm for predictive accounting of energy resources for calculators of engineering systems. This algorithm is implemented in the web application’s engineering calculator. The DHTML programming language is used as an implementation of the algorithm.
COMPARISON OF BRAKING MODES OF ASYNCHRONOUS AND SYNCHRONOUS HYSTERETIC ELECTRIC MOTORS IN THE ELECTRIC DRIVE OF AN ELECTROMECHATRONIC DEVICE
Authors: Анисимов М.Н. , Останин С.Ю. , Антаненков А.А. , Латыпов Т.С. 
Published: February 2023

Проведён сравнительный анализ режимов торможения асинхронного и синхронного гистерезисного электродвигателей в электроприводе электромехатронного устройства – рабочего механизма для современных и новых разрабатываемых машин по производству химических нитей. Показаны преимущества применения гистерезисных электродвигателей. Подтверждена точность математической модели, разработанной и использованной для проектирования гистерезисных электродвигателей.
A comparative analysis of the braking modes of asynchronous and synchronous hysteretic electric motors in the electric drive of an electromechatronic device – a working mechanism for modern and newly developed machines for the production of chemical filaments. The advantages of using hysteretic electric motors are shown. The accuracy of the mathematical model developed and used for the design of hysteretic electric motors is confirmed.
СРАВНИТЕЛЬНЫЙ АНАЛИЗ ЭЛЕКТРОПРИВОДОВ МЕХАТРОННОГО УСТРОЙСТВА НА БАЗЕ АСИНХРОННОГО И СИНХРОННОГО ГИСТЕРЕЗИСНОГО ЭЛЕКТРОДВИГАТЕЛЕЙ
Authors: Останин С.Ю. 
Published: February 2023

Проведён сравнительный анализ электроприводов мехатронного устройства на базе асинхронного и синхронного гистерезисного электродвигателей для рабочих механизмов современных и новых разрабатываемых технологических машин по производству химических нитей. Показаны преимущества применения гистерезисных электродвигателей. Подтверждена точность математической модели, разработанной и использованной для проектирования гистерезисных электродвигателей.
A comparative analysis of the electric drives of a mechatronic device based on asynchronous and synchronous hysteretic electric motors for the working mechanisms of modern and newly developed technological machines for the production of chemical filaments is carried out. The advantages of using hysteretic electric motors are shown. The accuracy of the mathematical model developed and used for the design of hysteretic electric motors is confirmed.
Anais do IV International Medical Conference of Piauí, XVIII Congresso Médico do Piauí e VI Congresso da SAMPI
Authors: (SAMPI) Sociedade dos Acadêmicos de Medicina do Piauí , Associação Médica Brasileira Divisão Piauí (AMB-PI) 
Published: February 2023

APRESENTAÇÃO:
O Congresso Médico do Piauí, que por anos representou o maior evento científico da classe médica do estado, teve seu projeto revitalizado em 2015, em parceria com a Associação Médica Brasileira - Divisão Piauí (AMB-PI) com a Sociedade dos Acadêmicos de Medicina do Piauí (SAMPI), para atualizá-lo conforme os modelos adotados pelas mais prestigiadas conferências do mundo. A nova proposta, que conta com uma programação dinâmica de palestras nacionais e internacionais, painéis de apresentação de trabalhos científicos e cursos práticos, revelou-se sucesso absoluto com mais de 900 resumos de artigos enviados para avaliação e 1900 inscritos nas últimas edições. O congresso possui certificação com o selo da Comissão Nacional de Acreditação (CDA), que é parte da Associação Médica Brasileira (AMB).
ANAIS DA VI MOSTRA CIENTÍFICA DE EXPERIÊNCIAS EXITOSAS EM ENFERMAGEM DO HU-UFPI/EBSERH
Authors: ALMEIDA GOMES BRAGA FRANCISCA DAS CHAGAS SHEYLA , PEREIRA COSTA JÉSSICA , DO LAGO SANTOS TÁGORA , PEREIRA DOURADO DANIELLE , ROCHA DUARTE DE CARVALHO MARIANNE , DA SILVA NASCIMENTO LYON RICHARDSON , JORGE BRANDÃO ADRIANA , SILVA VALE CAROLINA 
Published: February 2023

Anualmente a Semana de Enfermagem é celebrada em todo o país entre os dias 12 e 20 de maio. Dia 12, comemora-se o Dia Mundial do Enfermeiro, em alusão ao nascimento da precursora internacional da enfermagem Florence Nightingale. E dia 20, festeja-se o Dia Nacional dos Auxiliares e Técnicos de Enfermagem em memória à Ana Néri, maior personalidade da Enfermagem Brasileira.
A Divisão de Enfermagem realiza a X Semana de Enfermagem do HU-UFPI/EBSERH e VI Mostra Científica de Experiências Exitosas em Enfermagem do HU-UFPI/EBSERH com o tema: RESSIGNIFICANDO A ESSÊNCIA, O PROPÓSITO E OS SABERES DE ENFERMAGEM.
Alinhados à missão do HU-UFPI/EBSERH de fomentar a formação de recursos humanos por meio do desenvolvimento de ensino, pesquisa e extensão, a programação da Semana de Enfermagem 2022 compreende a realização de minicursos, palestras, apresentação de trabalhos, além de atividades socioculturais extensivas aos discentes e docentes da UFPI.
A Mostra de Experiências Exitosas em Enfermagem, busca apresentar trabalhos durante a Semana de Enfermagem do HU-UFPI/EBSERH realizadas pela equipe de enfermagem, de forma individual, multidisciplinar e/ou interprofissional, que ocorrem na Instituição, bem como docentes e discentes da Universidade federal do Piauí (UFPI).
Higher risk of SARS-CoV-2 Omicron BA.4/5 infection than of BA.2 infection after previous BA.1 infection, the Netherlands, 2 May to 24 July 2022
Authors: Andeweg Stijn P , de Gier Brechje , Vennema Harry , van Walle Ivo , van Maarseveen Noortje , Kusters Nina E , de Melker Hester E , Hahné Susan JM , van den Hof Susan , Eggink Dirk , Knol Mirjam J 
Published: February 2023

Background
In summer 2022, SARS-CoV-2 Omicron BA.5 became dominant in Europe. In vitro studies have shown a large reduction of antibody neutralisation for this variant.

Aim
We aimed to investigate differences in protection from previous infection and/or vaccination against infection with Omicron BA.4/5 vs BA.2.

Methods
We employed a case-only approach including positive PCR tests from community testing between 2 May and 24 July 2022 that were tested for S gene target failure (SGTF), which distinguishes BA.4/5 from BA.2 infection. Previous infections were categorised by variant using whole genome sequencing or SGTF. We estimated by logistic regression the association of SGTF with vaccination and/or previous infection, and of SGTF of the current infection with the variant of the previous infection, adjusting for testing week, age group and sex.

Results
The percentage of registered previous SARS-CoV-2 infections was higher among 19,836 persons infected with Omicron BA.4/5 than among 7,052 persons infected with BA.2 (31.3% vs 20.0%). Adjusting for testing week, age group and sex, the adjusted odds ratio (aOR) was 1.4 (95% CI: 1.3–1.5). The distribution of vaccination status did not differ for BA.4/5 vs BA.2 infections (aOR = 1.1 for primary and booster vaccination). Among persons with a previous infection, those currently infected with BA4/5 had a shorter interval between infections, and the previous infection was more often caused by BA.1, compared with those currently infected with BA.2 (aOR = 1.9; 95% CI: 1.5–2.6).

Conclusion
Our results suggest immunity induced by BA.1 is less effective against BA.4/5 infection than against BA.2 infection.
SINIF ÖĞRETMENİ ADAYLARININ GİRİŞİMCİLİK BECERİLERİNİN İNCELENMESİ: BİR KARMA YÖNTEM ARAŞTIRMASI
Authors: KAYA Aslıhan , GİRGİN Derya 
Published: February 2023

Bu araştırma sınıf öğretmeni adaylarının girişimcilik beceri düzeylerini çeşitli değişkenler bağlamında inceleyerek aralarındaki ilişkiyi belirlemeyi ve öğretmen adaylarının bu becerilere ilişkin görüşlerini ortaya koymayı amaçlamaktadır. Bu bağlamda araştırma, karma yöntem desenlerinden eş zamanlı karma desen kullanılarak yürütülmüştür. Araştırmanın örneklem ve çalışma grubunu Çanakkale On Sekiz Mart Üniversitesinde öğrenim gören sınıf öğretmeni adayları oluşturmaktadır. Araştırmanın nicel verileri Deveci ve Çepni (2015) tarafından geliştirilen “Girişimcilik Ölçeği” kullanılarak toplanırken, nitel veriler ise araştırmacı tarafından geliştirilen görüşme formu ile toplanmıştır. Araştırmanın nicel sonuçlarına göre, öğretmen adaylarının kendilerine yönelik girişimcilik beceri düzeylerinin hem ölçek bütününde hem alt boyutlarda orta değerlerin üzerinde olduğunu sonucuna ulaşılmıştır. Nitel sonuçlara dayalı olarak girişimcilik becerilerine ilişkin oluşturulan tema ve kodlar dikkate alındığında her iki türdeki verinin birbirini desteklediği görülürken, nitel bölümdeki girişimcilik öz yeterliği teması, düşük düzey öz yeterlik sonucu ile nicel bölümdeki sonuçtan farklılaşmıştır. Araştırmadan elde edilen sonuçlar bağlamında uygulayıcılar ile araştırmacılara yönelik öneriler geliştirilmiştir.
Anahtar Kelimeler: Girişimcilik becerileri, sınıf öğretmeni adayı, karma yöntem.