bluuebunny/crossref_metadata_2025_split huggingface dataset:
How should storm surge barrier maintenance strategies be changed in light of sea-level rise? A case study
Authors: Trace-Kleeberg Sunke , Haigh Ivan , Walraven Marc , Gourvenec Susan 
Published: February 2023

AbstractSea-level rise and changes in storminess, together with population growth and coastward migration, are increasing the risks of coastal flooding. The impacts are amplified in coastal cities due to the high concentration of inhabitants, infrastructure and services in low lying areas. Many coastal cities are located in estuaries, and storm surge barriers are often constructed to provide flood protection in these areas with long exposed coastlines. For these complex and unique structures, maintenance is vital to ensure they remain reliable and comply with legal protection standards. To ensure safe conditions for workers, storm surge barriers typically define water level thresholds, at which maintenance work must stop when these water levels are reached or exceeded. This paper evaluates the changes in past and future water levels exceeding the maintenance threshold to inform management, maintenance and operation strategies, and design, of storm surge barriers. The Maeslant barrier in Rotterdam, Netherlands is used as a case study to test this analysis. Water levels from measurements taken at the Hoek van Holland tide gauge are compared to the maintenance threshold level. The number of past threshold exceedances is determined and the sensitivity of exceedances to threshold level are assessed. Results show that the maintenance threshold has been exceeded 991 times of which 13% occurred during the maintenance season. Conversely, there were periods in the storm season when water levels were below the maintenance threshold and work could have been carried out safely. The effect of sea-level rise and natural inter-annual tidal cycles on future threshold exceedances is also assessed. Findings reveal that the maintenance window will shift earlier in the year and narrow until exceedances of the maintenance threshold occur regularly all year around. With 1 m sea-level rise maintenance threshold exceedances are likely to occur regularly all year around by 2048. This analysis highlights that maintenance strategies at the Maeslant barrier will need to be adapted for the barrier to remain operational until its design life of 2100. This is due to the increase in maintenance threshold exceedances resulting from natural interannual tidal cycles combined with sea-level rise. This analysis framework is applicable to existing barriers worldwide to assess future intervention points and for barriers in the design phase to verify the implications of design decisions on planned maintenance.
Genome size of grass Festuca mountain species from the Pyrenees and Prepyrenees: variation, evolution and new assessments
Authors: Garnatje Teresa , Catalán Pilar , Inda Luis A. , Vallès Joan , Pyke Samuel 
Published: February 2023

Abstract
Festuca is one of the most ecologically and economically important genera of temperate grasses. Species of its main subgenus Festucaare common components of cool-seasonal pastures and are especially frequent in mountainous areas, where there are often several morphologically similar species that grow in the same or comparable habitats and sometimes live in sympatry. Nuclear DNA assessments by flow cytometry can be used to identify taxa and uncover new ploidy levels in species complexes for which previous chromosome counts and genome sizes are known. 2C values of newly studied Pyrenean and Prepyrenean Festucasubgen. Festuca sects. Eskia, Festuca and Aulaxyperspecies range from 4.41 to 16.36 pg and include 2x, 4x, 6x and 8x ploidy levels. 2C mean values of diploids and polyploids are larger in the species of the more ancestral F. sect. Eskia group showing a decreasing trend in the species of the more recently evolved F. sects. Festuca and Aulaxyperlineages. Monoploid genome sizes of high polyploid Aulaxyper taxa are among the smallest of the three Festuca sections, corroborating previous findings. Our analysis provides new genome size values and inferred ploidy levels for hexaploid F. heteromallaand octoploid F. trichophylla and highlights the genomic and ecological differentiation of tetraploid F. gautieri susbsp. gautieri from diploid F. gautierisubsp. scoparia.
Successful systemic lysis therapy of a floating carotid thrombus in an acute stroke patient with known immune thrombocytopenic purpura on ongoing eltrombopag therapy and acute COVID-19 infection: A case report
Authors: Adam Lucas Christoph , Burgstaller Marian , Taetweiler Urs , Mueller Joerg 
Published: February 2023

Abstract
Background: Patients with immune thrombocytopenic purpura (ITP) under eltrombopag therapy are vulnerable to thrombotic disbalance either by disease and by therapy-related hypercoagulability. Vascular events such as the development of a free-floating carotid thrombus are known rare complications of acute COVID-19 infections due to an endothelial inflammation and underlying hypercoagulable state. New focal neurological symptoms in patients at risk should be immediately followed by angiographic diagnostics and, if necessary, proceed with the appropriate treatment immediately.
Case presentation: Here we report a case of a 38-old female with a medical history of ITP and presence of COVID-19 infection presenting an acute sensorimotor hemiparesis of the right side while oneltrombopag therapy. Initial CT angiography revealed a free-floating thrombus of the left carotid artery. At admission, platelet number was significantly increased at 896/nl. After systemic lysis therapy the thrombus was fully dissolved. Follow-up diffusion-weighted imaging revealed multilocular cortical infarction of the left ACM territory. The patient soon recovered and was released with residual mild sensorimotor deficits of the right arm. Eltrombopag was paused at admission, platelet number was quickly normalizing and the patient was discharged with a daily intake of acetylsalicylic acid, eltrombopag in reduced daily dose and weekly control of platelet number for 3 months.
Conclusions: This unique case enhances the need for caution in patients at vascular risk who exhibit an acute COVID-19 infection, and discusses thrombocytic derailment under thrombopoietin receptor agonist therapy associated with an acute COVID-19 infection.
Dietary Inflammatory Index, Erythrocyte Membrane Fatty Acids and Cognitive Function in Obese Chinese Population from 45 to 75 Years: Cross-Sectional and Mediation Analysis
Authors: Huang Hongying , Li Jinchen , Shen Jingyi , Zhao Tong , Xiao Rong , Ma Weiwei 
Published: February 2023

Abstract
Few studies have focused on the connection between dietary inflammatory index (DII) and cognitive function in obese people, despite the fact proved that both obesity and cognitive dysfunction are associated with chronic inflammation. Since DII can reflect the anti-inflammatory or pro-inflammatory potential of the diet, using the normal population as a reference we conducted a study in obese individuals to examine the relationship between DII and several cognitive functions in this population. Additionally, we investigate the mediating elements of this association. Higher DII scores were linked to lower Montreal cognitive assessment (MoCA) total scores, MoCA visuospatial function, MoCA naming, MoCA attention, and MoCA memory in the obese group, according to adjusted linear regression. Taking the tertile of DII score as a categorical variable substituted into a binary linear regression, the negative correlation between DII score and cognitive function score remains, as shown by the increasing incidence of mild cognitive impairment (MCI) as DII increases by one tertile. We discovered chained mediation effects in the mediation analysis between the DII score, erythrocyte membrane fatty acids and the overall MoCA score. We propose that in obese individuals, higher DII scores are linked to a deterioration in cognitive performance. Furthermore, the fatty acids in the erythrocyte membrane may mediate this action.
Acetylcholinesterase inhibition studies of alkaloid components from Crinum asiaticum var. sinicum plants: In vitro assessments by molecular docking and molecular dynamics simulations
Authors: Duc Ngo Viet , Trang Vu Thi , Anh Hoang Le Tuan , Ba Vinh Le , Phong Nguyen Viet , Thuan Tran Quang , Hieu Ngo Van , Dat Nguyen Tien , Nhan Le Van , Tuan Do Thanh , Thao Do Thi , Tai Bui Huu , Lien Le Quynh , Yang Seo Young 
Published: February 2023

Abstract

Alkaloids are among the most important and best-known secondary metabolites as sources of new drugs from medicinal plants and marine organisms. A phytochemical investigation of whole Crinum asiaticum var. sinicum plants resulted in the isolation of seven alkaloids (1–7), including one new compound (1). Their structures were elucidated using NMR and HR-ESI-MS. The absolute configuration of 1 was established by ECD. A molecular docking and molecular dynamics simulation was carried out for the isolated compounds to screen for acetylcholine (AChE) inhibitory activity. The target compounds were evaluated for their inhibitory effects on AChE activity in vitro. The results suggest that these C. asiaticum alkaloids possess the ability to treat Alzheimer’s disease.
Large enhancement of Curie temperature in Fe3GeTe2 by Fe intercalation in the van der Waals gap
Authors: Wu Yueshen , Hu Yuxiong , Wang Cong , Zhou Xiang , Xia Wei , Zhang Yiwen , Wang Jinghui , Ding Yifan , He Jiadian , Dong Peng , Bao Song , Wen Jinsheng , Guo Yanfeng , Watanabe Kenji , Taniguchi Takashi , Ji Wei , Wang Zhu-Jun , Li Jun 
Published: February 2023

Abstract
The magnetic and electrical transport properties of the two-dimensional ferromagnetic Fe3GeTe2 have proven to be a subject of intrigue, with a broad range of Curie temperatures (Tc) observed in recent studies, ranging from 160 K to 230 K, and even reaching room temperature by ionic gating. Despite these discoveries, the underlying mechanism behind the varying Tc values remains a puzzle. Here, we employed scanning transmission electron microscopy to explore the atomic structure of Fe3GeTe2 crystals exhibiting Tc values of 160, 210, and 230 K. The results of the elemental mapping reveal that Fe intercalation on the interstitial sites within the van der Waals gap is present in the high- Tc (210 and 230 K) samples. The electrical transport measurements demonstrate the presence of an exchange bias effect in these high- Tc samples, owing to the existence of ferromagnetic and antiferromagnetic interfaces, while this effect is absent in the low-Tc (160 K) samples. First-principles calculations further suggest that the Fe-intercalation layer may be responsible for the local antiferromagnetic coupling that gives rise to the exchange bias effect, and that the introduction of interlayer exchange paths greatly contributes to the enhancement of Tc. This discovery of the Fe-intercalation layer elucidates the mechanism behind the hidden antiferromagnetic ordering that underlies the enhancement of Tc in Fe3GeTe2.
Inflammatory and interferon gene expression signatures in patients with mitochondrial disease
Authors: Warren Emily , Gordon-Lipkin Eliza M. , Cheung Foo , Chen Jinguo , Mukherjee Amrita , Apps Richard , Tsang John S. , Jetmore Jillian , Kruk Shannon , Lei Yuanjiu , West A. Phillip , McGuire Peter J. 
Published: February 2023

Abstract
Background: People with mitochondrial disease (MtD) are susceptible to metabolic decompensation and neurological symptom progression in response to an infection. Increasing evidence suggests that mitochondrial dysfunction may cause chronic inflammation, which may promote hyperresponsiveness to pathogens and neurodegeneration.
Methods: We collected whole blood from a cohort of MtD patients and healthy controls and performed RNAseq to examine transcriptomic differences. We performed GSEA analyses to compare our findings against existing studies to identify commonly dysregulated pathways.
Results: Gene sets involved in inflammatory signaling, including type I interferons, interleukin-1β and antiviral responses, are enriched in MtD patients compared to controls. Monocyte and dendritic cell gene clusters are also enriched in MtD patients, while T cell and B cell gene sets are negatively enriched. The enrichment of antiviral response corresponds with an independent set of MELAS patients, and two mouse models of mtDNA dysfunction.
Conclusions: Through the convergence of our results, we demonstrate translational evidence of systemic peripheral inflammation arising from MtD, predominantly through antiviral response gene sets. This provides key evidence linking mitochondrial dysfunction to inflammation, which may contribute to the pathogenesis of primary MtD and other chronic inflammatory disorders associated with mitochondrial dysfunction.
Reconfigurable Geometrical Phase Spatial Light Modulator Using Short-Pitch Ferroelectric Liquid Crystals
Authors: Srivast Abhishek , SUN Zhi-Bo , YUAN Zheng-Nan , Swaminathan Vigneshwaran , Vashchenko Valerii , Vashchenko Olena , Cheung Alex Yuk Lung , LU Lei , Kwok Hoi-Sing 
Published: February 2023

Abstract
This article shows a fast continuous 2π geometrical phase modulator based on the dynamic optical axis rotation of the short-pitch Ferroelectric Liquid Crystal (FLC). A continuous multi-level (8-bit) phase modulation, fast switching time (< 250 μs at 2 kHz), low operating voltage (< 7 V), and high diffraction efficiency (> 77%) is achieved using defect-free Deformed Helix Ferroelectric Liquid Crystal (DHFLC) for the first time. We showed a minimum feature size of 1 µm without fringe field effect (FFE). We also developed a new FLC with a cone angle of ~85˚ and a way to provide compensated half-wave condition (HW) during the entire electro-optical operational range. As a result, we achieve both spatial and time modulation with high frequency (1/3 μm-1 and 4 kHz, respectively), which can be used in applications such as a real-time hologram and dynamic beam steering in Light Ranging and Detector (LiDAR).
Ultrafast energy transfer and charge separation dynamics in PSII-dimer from Thermosynechococcus vulcanus
Authors: Kosumi Daisuke , Bandou-Uotani Miki , Kato Shunya , Kawakami Keisuke , Yonekura Koji , Kamiya Nobuo 
Published: February 2023

Abstract
Cyanobacterial photosynthetic apparatus efficiently capture sunlight, and the energy is subsequently transferred to photosystem I (PSI) and II (PSII), to produce electrochemical potentials. PSII is a unique membrane protein complex that photo-catalyzes oxidation of water and majorly contains photosynthetic pigments of chlorophyll a and carotenoids. In the present study, the ultrafast energy transfer and charge separation dynamics of PSII from a thermophilic cyanobacteria Thermosynechococcus vulcanus have been investigated by femtosecond pump-probe spectroscopic measurements. The results demonstrated that the pheophytin anion PheoD1− generates with 43.0 ps at 140 K (14.8 ps at 296 K) and the secondary electron transfer to quinone: PheoD1−QA →PheoD1QA− occurs with 650 ps at 296 K upon excitation into the Qy band of chlorophyll a at 670 nm. On the other hand, an inefficient β-carotene → chlorophyll a energy transfer (33%) occurred after excitation to the S2 state of β-carotene at 500 nm. Instead, the carotenoid triplet state appeared in an ultrafast timescale after excitation at 500 nm.
Optimization of Machine Learning Algorithms Through Hyper-parameter Tuning Applied for the classification of Arabic news
Authors: JAMALEDDYN IMAD , AYACHI Rachid EL , BINIZ Mohmed 
Published: February 2023

Abstract
In the field of machine learning, hyperparameter tuning is a technique used to determine which learning algorithms have the most effective parameters. Using the Grid Search strategy as part of the machine learning algorithms, we suggest a few different ways to improve the accuracy of text categorization. In this research, we combined the TF-IDF feature selection approach with three different machine learning algorithms. These algorithms are Multinomial Logistic Regression MLR, Support Vector Machine SVM, and Artificial Neural Network ANN. According to the results of our tests, hyperparameter adjustment can significantly improve the classifier's performance.
Identification and validation of a novel anoikis-related prognostic model for prostate cancer
Authors: Zhang Peipei , Lv Wenzhi , Luan Yang , Cai Wei , Min Xiangde , Feng Zhaoyan 
Published: February 2023

Abstract

In this study, we collected gene expression profile, single nucleotide polymorphism mutation data, and copy number variation (CNV) info of 495 prostate cancer (PCa) patients from the TCGA database and downloaded 140 PCa samples from the MSKCC dataset as an external cohort. We extracted 434 anoikis-related genes from GeneCards and previous publications. We used unsupervised consensus cluster analysis to identify two molecular subtypes (C1 and C2). C1 exhibited a higher level of CNV amplification, immune score, stromal score, aneuploidy score, homologous recombination deficiency, intratumor heterogeneity, single-nucleotide variant neoantigens, and tumor mutational burden compared to C2. C2 showed a better survival outcome and was found to have a high level of gamma delta T cell and activated B cell infiltration. We then constructed a novel risk signature consisting of four genes (HELLS, ZWINT, ABCC5, and TPSB2) for predicting the overall survival of PCa patients using the univariate Cox regression analysis and the least absolute shrinkage and selection operator algorithm, which we validated using the MSKCC dataset. The receiver operating characteristic curve of the signature indicated that the area under the curve was 0.780, suggesting good predictive accuracy. We found that the risk signature was an independent prognostic factor for overall survival in PCa patients. Additionally, we identify four CTRP-derived compounds (cucurbitacin I, SB−743921, paclitaxel, and GSK461364) and four PRISM-derived compounds (volasertib, LY2606368, mitoxantrone, and dolastatin−10) for the treatment of high-risk group patients. Our findings may provide a new perspective for the treatment of anoikis-related PCa.
StockTwits Classified Sentiment and Stock Returns
Authors: Divernois Marc-Aurèle , Filipovic Damir 
Published: February 2023

Abstract
We classify the sentiment of a large sample of StockTwits messages as bullish, bearish or neutral, and create a stock-aggregate daily sentiment polarity measure. Polarity is positively associated with contemporaneous stock returns. On average, polarity is not able to predict next-day stock returns. But when we condition on specific events, defined as sudden peaks of message volume, polarity has predictive power on abnormal returns. Polarity-sorted portfolios illustrate the economic relevance of our sentiment measure.
JEL Classification: C55; G14; G17
A Mathematical Control Approach on Dengue Disease Fractional-Order Model Involving Mosquito Nets and Repellents Intervention
Authors: M Vijayalakshmi. G. , M Ariyanatchi 
Published: February 2023

Abstract
Throughout this work, we have explored a mathematical approach on the dengue disease fractional order dynamical system involving mosquito nets and repellents. For qualitative data analysis we have applied Caputo- Fabrizio operator on this model. The fertility rate and basal features of the mosquito are generally probed. The two steady states of the system have been examined for asymptotical stability analysis. The Lipchitz condition has been applied to gain survival and oneness of results of the system. According the sensitivity evaluation of reproduction rate of\({\mathcal{R}}_{0}\), using mosquito nets and insect repellent can reduce \({\mathcal{R}}_{0}.\) The Adams – Bashforth scheme is hired to solve an approximate response of the fractional-order dengue model. The numerical simulation indicates that the fractional-order influences the dynamics of dengue fever. An aggregate the usage of mosquitoes netting and insect repellents can lessen the range of infected individualities.
Assessment of changes in the natural head position and the pharyngeal airway after orthognathic surgery
Authors: Lin Xiaozhen 
Published: February 2023

Abstract
Objectives The natural head position (NHP), pharyngeal airway, and maxillofacial development are correlated. The author’s previous studies proved that following surgical correction of Skeletal Class II malocclusion, the pre-operative over-extended NHP returned upright, and the pharyngeal airway space (PAS) dimension expanded. The present study compares the post-operative change in the NHP and the PAS after orthognathic surgery in Skeletal Class II and III malocclusion patients.
Materials and Methods Patients receiving orthognathic procedures to correct Skeletal Class II or III malocclusions were reviewed in this retrospective study. Their pre-operative and 6-week post-operative cone-beam computed tomography datasets were collected. Variables representing the craniofacial pattern, the NHP, and the PAS were measured three-dimensionally. Post-operative variables were compared with their pre-operative counterparts using either repeat-measure 2-way analyses of variance or Wilcoxon matched-pairs signed rank test.
Results Forty-three cases of 61 patients were involved. After surgery, the differences in craniofacial pattern and the NHP between Skeletal Class II and III malocclusion groups decreased, and the PAS increased in both groups.
Conclusion Orthognathic surgery corrects dysgnathia, neutralizes the NHP, and increases the PAS in Skeletal Class II and III malocclusion patients.
Clinical relevance
Orthognathic surgery provides potential benefits to NHP and pharyngeal airway in addition to correcting maxillofacial deformities.
How Difficult Azide ion / Hydrazoic Acid Passes Biological Membranes: Experimental and Computational Study
Authors: Hartl Simona Lojevec , Žakelj Simon , Dolenc Marija Sollner , Smrkolj Vladimir , Mavri Janez 
Published: February 2023

Abstract
Hydrazoic acid (HN3) and its deprotonated form azide ion (N3ˉ) (AHA) are toxic since they inhibit cytochrome c oxidase complex IV (CoX IV) embedded in the inner mitochondrial membrane as part of the enzyme complexes of the respiratory chain. Especially critical for its toxicology is inhibition of CoX IV in the central nervous system and cardiovascular system. Hydrazoic acid is an ionizable species and its affinity toward membranes and therewith associated permeabilities depend on the pH values of aqueous media on both sides of the membranes. In article, we addressed permeability of AHA through the biological membrane. In order to understand affinity of the membrane for neutral and ionized form of azide we measured octanol-water partition coefficients at pH values of 2.0 and 8.0, which are 2.01 and 0.00034, respectively. By using Parallel Artificial Membrane Permeability Assay (PAMPA) experiment, we measured effective permeability through the membrane, which is logPe -4.97 and -5.26 for pH values of 7.4 and pH 8.0, respectively. Experimental permeability was used to validate theoretical permeability, which was estimated by numerically solving a diffusion equation for AHA diffusion through the membrane. We demonstrated that the rate of permeation through the cell membrane of 8.46 ·104 s-1 is much higher than the rate of chemical step of CoX IV inhibition by azide of 200 s-1. The results of this study show that transport through the membranes does not represent the rate-limiting step and therefore does not control the rate of CoX IV inhibition in the mitochondria. Observed dynamics of azide poisoning is however controlled by circulation transport that takes place on a minute time scale.