bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factors associated with the prevalence of depression among people with oculocutaneous albinism in Jinja,Uganda.A cross sectional study
Authors: Gaylord Inena wa inena , Patricia Binti Mosunga , Sebastien EtongoMozebo , Rachel Alinatwe , Ogik Peter , Faruck Kizza , Karuma Fazira , Pierre Ciza , Limengo Bambale , Roger Ilunga Muland , Muhumuza Joshua , Bives Mutume Nzanzu , Rehmus Wingfield , Ben Forry , Joseph Kirabira 
Published: February 2023

Abstract
Background
Depression is among the common psychiatric disorders with high prevalence in the general population.This prevalence is higher in vulnerable populations including people living with albinism. Despite the fact that several aspects linked with it have been found among people with oculocutaneous albinism in the Busoga region, limited information is available regarding prevalence of depression and its associated factors in the study area.The main objective of the present study was to determine the factors associated with the prevalence of depression among people with oculocutaneous albinism in Jinja.
Methods
A cross-sectional design was used to capture data from a study sample size of 384 adults living with oculocutaneous albinism who were involved in completion of the screening tests for depression Hopkins Symptom Checklist-25(HSCL-25).The summation of scores for depression were averaged and the probable depression determined for each participant using a cut-off of 1.75. Logistic regression analyses were used to examine associations between depression outcomes, socio-demographic and psychomedical factors.
Results
The analyses revealed that the prevalence of depression among people with oculocutaneous albinism in Jinjacity stands at 65.4%. Depression was significantly associated with age (AOR = 1.059, 95% CI = 1.020–1.100, P = 0.003), lack of family support (AOR = 0.505, 95% CI = 0.286–0.892, P = 0.019), history of diabetes mellitus (AOR = 12.030, 95% CI = 1.117–12.961, P = 0.040), marital status by being married(AOR = 0.505, 95% CI = 0.286–0.892, P = 0.019) and taking chronically medication (AOR = 6.583, 95% CI = 1.618–26.782, P = 0.008).
Conclusions
These findings show that the estimated prevalence of depression among people with oculocutaneous albinism in the study area is high and worrying. Age, marital status, lack of family support, history of diabetes mellitus, and taking chronically medication are important risk factors associated with the prevalence of depressive disorders. Strategies targeting early interventions are needed in order to reduce risk factors of the disease and improve the quality of life of people with oculocutaneous albinism in Jinja.
Cancer immunity marker RNA expression levels across gynecologic cancers: Implications for immunotherapy
Authors: Jou Jessica , Kato Shumei , Miyashita Hirotaka , Thangathurai Kartheeswaran , Pabla Sarabjot , DePietro Paul , Nesline Mary , Conroy Jeffrey , Rubin Eitan , Eskander Ramez , Kurzrock Razelle 
Published: February 2023

Abstract
Background:
Our objective was to characterize cancer immunity marker expression in gynecologic cancers and compare immune landscapes between gynecologic tumor subtypes and with non-gynecologic solid tumors.
Methods:
RNA expression levels of 51 cancer-immunity markers were analyzed in patients with gynecologic cancers vs. non-gynecologic cancers, and normalized to a reference population of 735 control cancers, ranked from 0-100, and categorized as low (0-24), moderate (25-74), or high (75-100) percentile rank.
Results:
Of the 72 patients studied, 43 (60%) had ovarian, 24 (33%) uterine, and 5 (7%) cervical cancer. No two immune profiles were identical according to expression rank (0-100) or rank level (low, moderate, or high). Patients with cervical cancer had significantly higher expression level ranks of immune activating, pro-inflammatory, tumor infiltrating lymphocyte markers and checkpoints than patients with uterine or ovarian cancer (p<0.001 for all comparisons). However, there were no significant differences in immune marker expression between uterine and ovarian cancers. Tumors with PD-L1 TPS =>1% versus 0% had significantly higher expression levels of pro-inflammatory markers (58 vs. 49%, p=0.0004). Compared to patients with non-gynecologic cancers, more patients with gynecologic cancers express high levels of IDO-1 (44 vs. 13%, p<0.001), LAG3 (35 vs. 21%, p=0.008) and IL10 (31 vs. 15%, p=0.002.)
Conclusions:
Patients with gynecologic cancers have complex and heterogeneous immune landscapes that are distinct from patient to patient and from other solid tumors. High levels of IDO1 and LAG3 suggest that clinical trials with IDO1 inhibitors or LAG3 inhibitors, respectively, may be warranted in gynecologic cancers.
Chromone-embedded Peptidomimetics and Furopyrimidines as Highly Potent SARS-CoV-2 Infection Inhibitors: A Molecular Docking Study
Authors: Senobari Zahra Shakibay , Hosseini Mohsen Masoumian , Teimouri Mohammad Bagher , Rezayan Ali Hossein , Samarghandian Saeed , Hekmat Azadeh 
Published: February 2023

Abstract
Background: Coronavirus disease 2019 (COVID-19) is a respiratory illness caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Controlling the spread of viruses is one of the main concerns of pharmaceutical companies. Looking at the viral infection cycle can lead to the development of effective drugs. Since cell entry and replication of SARS-CoV-2 play a crucial role in the life cycle of CoV, this study investigated how derivatives of chromone compounds inhibit viral entry and prevent viral replication.
Method: In this study, the inhibitory effect of chromone-embedded peptidomimetics and furopyrimidines on 7BZ5 (spike receptor binding domain) from Severe acute respiratory syndrome CoV 2, Homo sapiens, and 6LU7 (main protease domain) from Bat SARS-like CoV were investigated via molecular docking. The crystal structure of these proteins was taken from the Protein Data Bank (PDB). The ligand binding interaction option was used to determine the inhibition site. For structure preparation, unwanted molecules were removed, and the 3D structure was protonated and energetically minimized using Molecular Environment Operation (MOE) software. The chromone derivatives were first designed in three dimensions, and their energy was minimized using MOE 2019. Then, the online software SwissADME was used to calculate the molecular drug likeness. Lipinski and Benigni-Bossa's rule evaluated chromone derivatives, and toxicity was calculated using Toxtree v3.1.0 software. Then the compounds with pharmacological properties were selected for molecular docking. Interactions were assessed by molecular docking with MOE 2019, and the S score was calculated.
Result: The pharmacokinetic tests showed that the chromone derivatives of the peptidomimetic family had acceptable pharmacokinetic activity in the human body. Some compounds exhibited pronounced medicinal properties, including Ch-p1, Ch-p2, Ch-p6, Ch-p7, Ch-p12, and Ch-p13. Molecular docking also showed that these compounds bound with high affinity to the main protease of SARS-CoV-2. Ch-p7 had the highest binding energy, with an S-score of -8.7370. This compound was bound to Gln189 via a benzene ring and Asn142 via three bonds. Therefore, it is likely that the inhibitory property of this compound is more effective than the other compounds in this study.
Conclusions: For the virus to replicate in the host cell, SARS-CoV-2 must bind to the receptor via the receptor-binding domains of the S1 subunit and then be proteolytically processed by the main protease. In the present study, the inhibition of viral replication was investigated, and the results showed that chromone derivatives were effective. Compared to other studies on this subject, chromone derivatives from the peptidomimetic family had a high inhibitory effect.
Evaluation of the antidermatophytic activity of potassium salts of N-acylhydrazinecarbodithioates and their aminotriazole-thione derivatives
Authors: Ciesielska Anita , Kowalczyk Aleksandra , Paneth Agata , Stączek Paweł 
Published: February 2023

Abstract
Nowadays, dermatophyte infections are relatively easy to cure, especially since the introduction of orally administered antifungals such as terbinafine and itraconazole. However, these drugs may cause side effects due to liver damage or their interactions with other therapeutics. Hence, the search for new effective chemotherapeutics showing antidermatophyte activity seems to be the urge of the moment. Potassium salts of N-acylhydrazinecarbodithioates are used commonly as precursors for the synthesis of biologically active compounds. They were also found to act as antimicrobials, including activity against Candida spp. strains. Keeping that in mind, the activity of a series of five potassium N-acylhydrazinecarbodithioates (1a-e) and their aminotriazole-thione derivatives (2a-e) was evaluated against a set of pathogenic, keratinolytic fungi, but also against some Gram-positive and Gram-negative bacteria. All tested compounds were found non-toxic for L-929 and HeLa cells, with the IC30 and IC50 values assessed in the MTT assay above 128 µg/mL. The compound 5-amino-3-(naphtalen-1-yl)-4,5-dihydro-1H-1,2,4-triazole-5-thione (2d) was found active against all fungal strains tested. Scanning Electron Microscopy (SEM) revealed inhibition of mycelium development of T. rubrum cultivated on nail fragments and treated with 2d 24 h after infection with fungal spores. TEM (Transmission Electron Microscopy) observation of mycelium treated with 2d showed ultrastructural changes in the morphology of hyphae. Finally, the RNA-seq analysis indicated that a broad spectrum of genes responded to stress induced by the 2d compound. In conclusion, the results obtained confirm the potential of N-acylhydrazinecarbodithioate derivatives for future use as promising leads for the development of new antidermatophyte agents.
Expression of a deep-sea bacterial laccase from Halomonas alkaliantarctica and its application in dyes decolorization
Authors: Wang Jingjing , Zhang Ran , Zhu Guilan , Wang Lingling , Bai Han , Qian Yong , Zhou Xiazhen , Yin Qiang , Zhang Yan 
Published: February 2023

Abstract
Introduction Laccase is a copper-containing polyphenolic oxidase widely found in bacteria, archaea, fungi, animals, and plants. As a green biocatalyst with considerable potential for numerous environmental and industrial applications, the enzyme production efficiency of laccase in nature is low, and the cost is high.
Purpose To examine the characterization and potential applications of laccase in this study, a novel laccase from Halomonas alkaliantarctica (LacHa) was cloned and heterologously expressed in Escherichia coli.
Results To achieve heterologous and efficient laccase expression, a bacterial laccase gene designed as LacHa from Halomonas alkaliantarctica of deep sea was cloned and expressed in E. coli. The results showed that the optimum temperature and pH of the enzyme reaction were 45°C and 7.5. The 100 μM Cu2+ and Fe2+ ions had the strongest stimulatory effect on laccase activity, the surface-active agent SDS and organic solvent 5% ethanol had opposite effect. EDTA, and 5% DMSO have no effect on LacHa activity. The activity of LacHa was enhanced 1.5 fold by chloride at concentrations lower than 500 mM, and 57.6% of its initial activity remained in the reaction system containing 1000 mM NaCl. Furthermore, LacHa showed decolorization rates ranging from 90.28% to 100% for indigo carmine and two azo dyes without mediators, with wide pH (5.0-9.0) and temperature (25-65°C) ranges.
Conclusions In the present study, LacHa was expressed and showed unusual properties, suggesting its great application potential in the treatment of textile industries or environmental applications.
VANET Security Enhancement in Cloud Navigation with Internet of Things Based Trust Model in Deep Learning Architecture
Authors: Gnanajeyaraman Gnanajeyaraman , U Arul , G Miichael , A Selvakumar , S Ramesh , T Manikandan 
Published: February 2023

Abstract
Many intelligent services are available for developing sensor-based vehicle-to-vehicle communication systems through vehicular ad hoc network (VANET). Although neighbour locating and interconnected vehicle sensor processes have been improved by geographic routing methods. However, reliability and data continuity among data routing are crucial for developing transportation systems due to the high level of mobility and realistic environment.The vehicles' wireless communication is also unrestricted and open, making them more vulnerable to security threats and compromising data for improper uses.This research propose novel technique in security improvement in VANET with vehicle cloud based navigation and trust model using deep learning techniques. the vehicle network navigation is carried out using cloud network integrated with IoT and its data transmission to the base station is analysed. then the navigated vehicle security is enhanced using trust based federated transfer quadratic authentication system. the experimental analysis is carried out based on number of vehicles in network as well as its security enhancement. the parameters analysed are throughput, data transmission rate, latency, network traffic analysis, scalability. the proposed technique attained throughput of 95%, data transmission rate of 67%, latency of 56%, network traffic analysis of 76%, scalability of 75%
Effects of Transcranial Electrical Stimulation to the Right Posterior Parietal Cortex on Physical Control Responses
Authors: Mitsutake Tsubasa , Nakazono Hisato , Taniguchi Takanori , Yoshizuka Hisayoshi , Sakamoto Maiko 
Published: February 2023

Abstract
The posterior parietal cortex (PPC) plays an important role in postural stability by adapting to changes in input from the visual, vestibular, and proprioceptive systems. However, it is little known whether transcranial electrical stimulation (tES) of the PPC affects reactive postural responses. The purpose of this study was to investigate changes in physical control responses to anodal and cathodal transcranial direct current stimulation (tDCS) and transcranial random noise stimulation (tRNS) of the right PPC using a simultaneous inertial measurement unit. The joint movements of the lower limb of 33 healthy volunteers were measured while standing on a soft-foam surface with eyes closed, during various stimulation modalities. These modalities included anodal, cathodal tDCS, and sham stimulation in Experiment 1 and tRNS and sham stimulation in Experiment 2. The results showed that cathodal stimulation significantly decreased the joint angular velocity in the hip rotation, ankle inversion-eversion, and abduction-adduction directions compared to anodal or sham stimulation in Experiment 1. In contrast, there were no significant differences in physical control responses with tRNS stimulation in Experiment 2. These findings suggest that tES of the right PPC may modulate physical control responses; however, the effect depends on the stimulus modality.
Semi-Harmonic Maps from Tori and Sphere into Sphere
Authors: Aminian Mehran 
Published: February 2023

Abstract
The aim of this paper is considering semi-harmonic maps from a flat and non flat torus into a sphere, and between 2-spheres. At first we introduce semi-harmonic maps and then we consider these maps between tori and sphere.
MSC2010: 58E20; 53C43
Numerical analysis of thorax injury caused by the blunt impact of SIR-X sponge grenade
Authors: Chen Chaoming , Zhao Fadong , Ma Zongmin 
Published: February 2023

Abstract
To effectively assess the injury risk of the blunt impact of the SIR-X sponge grenade on the human thorax, In this paper, we used a numerical simulation technique to test the non-lethal kinetic energy projectiles that blunt impact on the Hybrid Ⅲ 50th dummy model. By simulating the effect of the L5 projectile on the thorax of the Hybrid Ⅲ 50th dummy model, about NATO standard AEP-99 (2021 edition), the thoracic displacement curves of the dummy model in three testing conditions were obtained in the validation corridors. The idea of replacing the finite element model of the human body with the Hybrid Ⅲ 50th dummy finite element model was proposed. We considered the difficulty in obtaining data due to the large deformation of the contact position when the SIR-X sponge grenade impacts the dummy's thorax. We proposed a mathematical model to predict the impact injury of the human thorax using the rib displacement measured by the rib displacement sensor of the Hybrid III 50th dummy. We simulated the SIR-X sponge grenade blunt impacting the dummy model's thorax. The measured rib displacement was used to predict and analyze the injury risk of the human thorax, providing a specific data reference for practical application.
Energy optimization in additive manufacturing based on cluster-aware enhanced spider monkey optimization
Authors: Bhuvaneswari R.Bhuvaneswari , N. Nagabhooshanam , M Chandralekha , D Sendil Kumar , Babu Gadde.Raghu , A.K. Chakravarthy , Praveen Neti , P. Ganeshan , Kannan Sathish 
Published: February 2023

Abstract
Additive manufacturing (AM) is a leading technology used in many fields, such as medicine and aerospace, to make prototypes and functional part fabrication. The energy requirements of the AM process are considerable and have serious consequences for environmental health and long-term viability. Research in both the private and public sectors has shifted its attention to the problem of predicting and optimising the amount of energy that AMs use.Material state, process operation, part and process design, working environment, and other factors all play a role in this problem. Existing research shows that the design-relevant aspects have a significant role in AM energy consumption (EC) modelling in reality, although this topic has not received enough attention. As a result, this research starts by analysing the design relevant features (DRFs) from the perspective of energy modelling.Before production, these features are normally decided by part designer (PD)and process operator (PO).An ANN driven cluster-aware enhanced spider monkey optimization algorithm (CAESMOA) is suggested to improve the energy utility relying on the novel modelling methodology. Deep learning is used to improve the global best of CAESMOA and solve a number of concerns, including speeding up search times. In order to verify the accuracy of the suggested modelling technique, DRFsare obtained from a functioning AM system in the production line. In our research, we use a normalisation strategy to filter out extraneous information. At the same time, optimization has been performed to direct PD and PO towards design and decision modifications that lessen the energy requirements of the specified AM system under investigation.The effectiveness of the suggested approach is examined, and the efficiency is also contrasted with that of other current methods. These statistics showed that our approach to energy optimization in AM delivered the most trustworthy outcomes.
Sound and rhythm impact on soil biofilm-forming ability
Authors: Fičko Karlo , Palijan Goran 
Published: February 2023

Abstract

Modern civilization is producing alarming levels of noise which often is developed in soil proximity having an opportunity to influence soil organisms. Yet, its effects on soil microbial communities are unexplored. To investigate the effects of different sound types we tested classical music of Mozart and Beethoven, construction, and road works noise and rhythm played on drums at the environmentally relevant sound levels and time intervals. All tested sounds impacted soil biofilm forming ability but differently between soil and land use types. Agricultural fields were less impacted by noise. Interestingly only regular rhythm stimulated all tested samples. Such results are the first evidence that noise can change the functional properties of soil microbial communities and that its effects are dependent on the type of sound.
Selective concurrence of the long non-coding RNA MALAT1 and the Polycomb Repressive Complex 2 to promoter regions of active genes in MCF7 breast cancer cells
Authors: Arratia Felipe , Fierro Cristopher , Blanco Alejandro , Fuentes Sebastian , Nahuelquen Daniela , Montecino Martin , Rojas Adriana , Aguilar Rodrigo 
Published: February 2023

Abstract
Background:The collaboration between the Polycomb Repressive Complex 2 (PRC2, an epigenetic modifier) and long non-coding RNAs (lncRNAs) has become a paradigm for gene regulation studies. In cancer cells, the MALAT1 lncRNA has arisen as a key partner for PRC2. However, it is unknown whether this partnership occurs genome-wide at the chromatin level, as most of the studies focus on single -usually repressed- genes. Due to the genomic binding properties of both macromolecules, we wondered whether there are binding sites shared by PRC2 and MALAT1.
Results: Using public genome-binding datasets for PRC2 and MALAT1 derived from independent ChIP- and CHART-seq experiments performed in the breast cancer cell line MCF7, we searched for regions containing PRC2 and MALAT1 overlapping peaks. Peak calls for each molecule were performed using MACS2 and then overlapping peaks were identified by bedtools intersect. Using this approach, we identified 1,293 genomic sites where PRC2 and MALAT1 concur. Interestingly, 54,75% of those sites are within gene promoter regions (<3000 bases from the TSS). These analyses were also linked with transcription profiles of MCF7 cells, obtained from public RNA-seq data. Hence, it was determined that MALAT1 and PRC2 can concomitantly bind to promoters of genes that are actively transcribed in MCF7 cells. Gene ontology analyses revealed an enrichment of genes related to categories including cancer malignancy and epigenetic regulation.
Conclusions: By re-visiting occupancy and transcriptomic data we identified a novel subset of genes, including key cancer-related genes, where MALAT1 and PRC2 may collaborate to control transcription.
Recommendations for an Early Safety Assessment in General Practice Training
Authors: Woods Amelia , Pitot Michelle , Elliot Taryn , Benson Jill 
Published: February 2023

AbstractAssessing the safety of new GP registrars is critical for the safety of patients, the registrar themselves and for their practice. The aim of an Early Safety Assessment (ESA) is to assess safety in independent practice, competency in self-assessment, appropriate help-seeking, knowledge and practice. The aim was to explore what should be included in an ESA, and the acceptability and feasibility of recommendations. A literature review, environmental scan, review of documents and ESA data from participating Australian GP Regional Training Organisations (RTOs), interviews with Directors of Training from participating RTOs, and a Delphi consensus were conducted. The study found that ESAs vary, both in content and timing. Recommendations were developed for their utility and feasibility. The ESA should end when the registrar is either flagged or found to be ‘safe to practice with the supervisor available most of the time’. There are barriers that can be addressed and facilitators to be encouraged so an ESA can be successfully implemented.