bluuebunny/crossref_metadata_2025_split huggingface dataset:
Penser l'avenir
Authors: Auzoult Laurent 
Published: February 2025

Si le futur est indéterminé et relativement ouvert, il s’avère possible d’agir et de penser de façon à modifier les possibilités ou les préférences que nous élaborons vis-à-vis de l’avenir. Deux questions se posent alors : comment se structurent, évoluent les représentations de l’avenir et comment nos prédictions ou nos attentes s’actualisent-elles dans le futur ? Cet ouvrage répond à ces deux questions. Il traite des contenus et des processus conduisant à l’élaboration des représentations individuelles et collectives de l’avenir. Il aborde également la façon dont tout un chacun construit des projets, fait face à l’avenir à travers ses menaces et ses opportunités. À ce niveau, on considèrera les conduites humaines comme étant finalisées, orientées, intentionnelles et ancrées dans des contextes qui déterminent nos contenus de pensées et circonscrivent les possibles en matière d’action. Enfin, on évoquera quelques pratiques psychologiques pouvant relever de la prospection et de l’anticipation c’est-à-dire de la simulation dans trois champs d’application : l’accompagnement thérapeutique, l’orientation scolaire et professionnelle et la prévention en matière de santé.
Challenges experienced by Gauteng Foundation Phase departmental heads in managing teaching and learning
Authors: Mhlongo Asser R. , Chaane Tshidisegang M. 
Published: February 2025

Background: The quality of teaching and learning depends on the school management team’s support and monitoring of teachers and learners to achieve the school’s objectives. Poor monitoring and lack of support compromise quality education.Aim: The study examined the challenges faced by Foundation Phase departmental heads in managing and monitoring teaching and learning processes at six primary schools in the Tshwane region.Setting: The study employed purposive sampling to select participants from six primary schools in the Tshwane West region, sampling six departmental heads of the Foundation Phase.Method: A qualitative research design was used to conduct the study. Fayol’s administrative management theory underpinned the study as its theoretical framework, and the interpretivist paradigm was used as the lens through which to view the phenomenon under study.Results: The study revealed that departmental heads are overworked regarding their responsibilities in the Foundation Phase.Conclusion: It is highly recommended that the Department of Basic Education (DBE) develop guidelines to streamline departmental heads’ responsibilities, prioritise core functions, delegate tasks and provide support mechanisms, like regular training, capacity-building programmes, and administrative assistance. Empowering teachers to take leadership roles can foster a culture of distributive leadership.Contribution: The study’s contributions include identifying specific challenges departmental heads encounter, emphasising the need for targeted support and training, and providing insights for education policymakers to improve teaching and learning outcomes and enhance the quality of education in the Foundation Phase.
Evaluating Hemagglutination Inhibition Antibody Titers as a Correlate of Protection for Influenza: A Sensitivity Analysis Based on Information Theory and Causal Inference
Authors: Ong Fenny , Molenberghs Geert , Callegaro Andrea , Van Der Elst Wim , Verbeke Geert , Stijven Florian , Van Keilegom Ingrid , Abad Ariel Alonso 
Published: February 2025

Abstract

Introduction:
Identifying hemagglutination inhibition (HI) antibody titers as a key immune correlate of protection (CoP) is crucial for developing, licensing, and monitoring the ongoing effectiveness of new influenza vaccines. Using a new statistical methodology, we explored the link between an inactivated quadrivalent influenza vaccine’s impact on HI antibody titers and its effectiveness against A/H1N1-associated influenza illness.

Methods:
We utilized data from a phase 3, observer-blind, randomized, controlled trial in children aged 6–35 months to assess HI antibody titers as an immune CoP. The assessment used a statistical method developed within a causal inference framework and a new information-theoretic metric of surrogacy, the so-called individual causal association (ICA).

Results:
The 75% and 85% uncertainty intervals of the ICA are 0.5511–0.8282 and 0.3632–0.8684, respectively, indicating a substantial reduction in the uncertainty about the vaccine’s effect on the absence of infection when its impact on the HI antibody titers is known.

Conclusions:
The evaluation yielded evidence supporting the validity of HI antibody titers as a CoP for influenza infection.
Efficacy of microwave ablation vs laparoscopic hepatectomy for primary small liver cancer: A comparative study
Authors: Li Huan-Song , Zhang Xuan-Feng , Fu Jun , Yuan Bo 
Published: February 2025

BACKGROUND
In-depth comparative investigations in terms of clinical efficacies of liver tumor microwave ablation (MWA) and laparoscopic hepatectomy (LH), which are both important treatment modalities for liver neoplasms, have been limited in patients diagnosed with primary small liver cancer (PSLC).
AIM
To compare and analyze the clinical efficacy of liver tumor MWA and LH for PSLC.
METHODS
This study retrospectively analyzed the medical records of 123 patients with PSLC admitted to Xuzhou Central Hospital from January 2015 to November 2022 and categorized them based on treatment modalities into the LH and MWA groups. The LH group, consisting of 61 cases, received LH, and the MWA group, which included 62 cases, underwent liver tumor MWA. Basic data and various perioperative indicators were compared between the two groups, including changes in liver function indicators [alanine aminotransferase (ALT), glutamic aminotransferase (AST), and total bilirubin (TBIL)] pre- and post-treatment, and efficacy and postoperative complications were analyzed.
RESULTS
No statistically significant difference was observed between the two groups in terms of age, gender, tumor diameter, liver function Child-Pugh classification and number of tumors, body mass index, and educational status (P > 0.05). The overall effective rate was higher in the MWA group than in the LH group (98.39% vs 88.52%) (χ 2 = 4.918, P = 0.027). The MWA group exhibited less operation time, intraoperative bleeding, defecation time, and hospital stay than the LH group (P < 0.05). No difference was found in liver function indicators between the two groups pre-treatment (P > 0.05), and ALT, AST, and TBIL levels decreased in both groups post-treatment, with the MWA group demonstrating lower levels (P < 0.05). The MWA and LH groups exhibited postoperative complication rates of 4.84% and 19.67%, respectively, with statistically significant differences between the two groups (P = 0.012, χ 2 = 6.318).
CONCLUSION
MWA is more effective in treating PSLC, and it promotes faster postoperative recovery for patients, and more security improves liver function and reduces postoperative complications compared to LH.
Successful management of bleeding ectopic small bowel varices secondary to portal hypertension: A retrospective study
Authors: Xiao Nian-Jun , Chu Jian-Guo , Ning Shou-Bin , Wei Bao-Jie , Xia Zhi-Bo , Han Zhe-Yi 
Published: February 2025

BACKGROUND
Bleeding ectopic varices located in the small bowel (BEV-SB) caused by portal hypertension (PH) are rare and life-threatening clinical scenarios. The current management of BEV-SB is unsatisfactory. This retrospective study analyzed four cases of BEV-SB caused by PH and detailed the management of these cases using enteroscopic injection sclerotherapy (EIS) and subsequent interventional radiology (IR).
AIM
To analyze the management of BEV-SB caused by PH and develop a treatment algorithm.
METHODS
This was a single tertiary care center before-after study, including four patients diagnosed with BEV-SB secondary to PH between January 2019 and December 2023 in the Air Force Medical Center. A retrospective review of the medical records was conducted. The management of these four patients involved the utilization of EIS followed by IR. The management duration of BEV-SB in each patient can be retrospectively divided into three phases based on these two approaches: Phase 1, from the initial occurrence of BEV-SB to the initial EIS; phase 2, from the initial EIS to the initial IR treatment; and phase 3, from the initial IR to December 2023. Descriptive statistics were performed to clarify the blood transfusions in each phase.
RESULTS
Four out of 519 patients diagnosed with PH were identified as having BEV-SB. The management duration of each phase was 20 person-months, 42 person-months, and 77 person-months, respectively. The four patients received a total of eight and five person-times of EIS and IR treatment, respectively. All patients exhibited recurrent gastrointestinal bleeding following the first EIS, while no further instances of gastrointestinal bleeding were observed after IR treatment. The transfusions administered during each phase were 34, 31, and 3.5 units of red blood cells, and 13 units, 14 units, and 1 unit of plasma, respectively.
CONCLUSION
EIS may be effective in achieving hemostasis for BEV-SB, but rebleeding is common, and IR aiming to reduce portal pressure gradient may lower the rebleeding rate.
Efficacy of water infusion combined with defoamers in colonoscopy
Authors: Li Jian , Chen Jun-Ping , Lai Chun-Han , Fu Lian , Ji Yong 
Published: February 2025

BACKGROUND
Currently, colonoscopy still needs continuous optimization and exploration of novel alternative approaches to enhance the experience of patients during colonoscopy.
AIM
To analyze the efficacy of water infusion combined with defoamers in colonoscopy.
METHODS
This study included 97 patients undergoing colonoscopy from January 2024 to June 2024. The participants were categorized into two groups, namely, the control group (n = 47), who underwent conventional colonoscopy, and the experimental group (n = 50), who received colonoscopy using water injection combined with defoamers. A comparative analysis was then conducted on the disease detection rate (colonic polyps, colonorrhagia, colonic ulcers, colonic mucosal lesions, and others), colonoscopy duration, abdominal pain [visual analog scale (VAS)], Boston bowel preparation scale (BBPS), self-rating anxiety scale (SAS), bowel preparation comfort, complications (intestinal perforation, bleeding, nausea and vomiting, abdominal pain, and abdominal distension), and patient satisfaction.
RESULTS
The experimental group demonstrated a significantly higher total disease detection rate, BBPS scores, and patient satisfaction compared with the control group. Further, the research group exhibited shorter colonoscopy duration, lower VAS and SAS scores and total complication rate, and better patient comfort and satisfaction.
CONCLUSION
These results indicate that the combination of water injection and defoamers exhibited an overall better therapeutic effect than conventional colonoscopy, mainly reflected in higher disease detection rate, faster examination efficiency, lower abdominal pain, anxiety, and complication incidences, and significantly better bowel preparation, comfort, and patient satisfaction.
Coronary heart disease with pulmonary embolism: A case report
Authors: Xu Jun-Qing , Jiang Meng-Xin , Wang Feng , Yang Kai-Qiang , Xu Ying-Jiang , Wang Yu-Jiu , Dong Sheng-Jun 
Published: February 2025

BACKGROUND
Coronary heart disease (CHD) and pulmonary embolism (PE) are thrombotic diseases. Patients with CHD and PE are common in clinical practice. However, the clinical diagnosis of PE is challenging due to overlapping primary symptoms, such as chest tightness and dyspnea. This confluence frequently leads to the misdiagnosis of PE, thus precipitating treatment delays and compromising patient outcomes. Herein, we report the case of a patient with both diseases who underwent surgery and medication therapy.
CASE SUMMARY
A 51-year-old man with a history of hypertension for 2 years visited a local hospital because of paroxysmal chest tightness for 1 d and was diagnosed with CHD. However, he refused hospitalization. He visited our hospital for the treatment of recurring symptoms. A comprehensive examination after admission revealed elevated D-dimer levels, and computed tomography pulmonary angiography was performed to confirm the diagnosis of PE. The patient successfully underwent coronary artery bypass grafting with anticoagulant and antiplatelet drugs and had a prognosis.
CONCLUSION
D-dimer is useful in screening for PE, whereas computed tomography pulmonary angiography is important for diagnosis. For patients with CHD and PE, coronary artery bypass grafting combined with anticoagulant and antiplatelet therapy is feasible.
Comprehensive understanding of a rare disease: Cardiac metastatic tumor, a double-center 10-year case review
Authors: Luo Ling-Yun , Yang Tian-Shu , He Zhen , Lin Li , Luo Xue-Lian 
Published: February 2025

BACKGROUND
Cardiac metastatic tumors (CMTs) are rare yet pose significant medical concerns. Clinical studies on CMT are limited, particularly those involving multicenter data analysis.
AIM
To systematically analyze the etiology, sources, classification, treatment, and prognosis of CMT.
METHODS
A total of 226 CMT patients from two centers (2013 to 2023) were reviewed, and 153 tumor patients from China Health and Retirement Longitudinal Study were used as controls. The survival rates of 96 CMT patients were tracked through medical records and telephone follow-ups. Logistic regression and survival analyses were conducted to characterize CMT.
RESULTS
CMTs were predominantly male (67.26% vs 39.47%, P < 0.001). Intracardiac metastasis patients had worse heart and coagulation function than pericardial metastasis patients (prothrombin time: 13.90 vs 13.30, P = 0.002), D-dimer levels (2.16 vs 0.85, P = 0.001), B-type natriuretic peptide (BNP) levels (324.00 vs 136.50, P = 0.004), and troponin levels (5.35 vs 0.03, P < 0.001)). Lung and liver cancers were the predominant primary tumor types in CMT. Patients with lung cancer (76.40% vs 30.77%) and thymoma (7.45% vs 1.54%) exhibited a higher prevalence of pericardial metastasis, while those with liver cancer (35.38% vs 0.62%) showed a higher prevalence of intracardiac metastasis. Overall survival was better for pericardial metastasis than for intracardiac metastasis patients (median survival: 419 days vs 129 days, log-rank test P = 0.0029). Cox proportional hazards model revealed that advanced age [hazard ratio (HR) = 1.034, 95% confidence interval (95%CI): 1.011-1.057] and higher BNP and troponin levels (HR = 1.011, 95%CI: 1.004-1.018) were associated with worse survival. Surgery significantly improved the survival rate of patients. The median survival time was 275 days for patients who did not undergo surgery and 708 days for those who had surgery (log-rank test P = 0.0128)
CONCLUSION
Clinicians should consider CMT in the male lung or liver cancer patients with cardiac symptoms. Abnormal coagulation, impaired heart function, tumor location, and age are key prognostic factors for CMT. Surgical intervention is the preferred treatment option, as it significantly prolongs median survival.
Updates in breathomics behavior in ischemic heart disease and heart failure, mass-spectrometry
Authors: Marzoog Basheer Abdualah , Chomakhidze Peter , Gognieva Daria , Parunova Alena Yurievna , Demchuk Snezhana Nikolaevna , Silantyev Artemiy , Kuznetsova Natalia , Kostikova Anastasia , Podgalo Dmitrii , Nagornov Evgeny , Gadzhiakhmedova Aida , Kopylov Philipp 
Published: February 2025

BACKGROUND
Cardiovascular disease (CVD) and associated sequalae remain the leading cause of disability worldwide. Ischemic heart disease (IHD) and heart failure are the most common etiologies of morbidity and mortality worldwide. This is due to the poor diagnostic and management methods for heart failure and IHD. Early detection of related risk factors through modern strategies is underestimated and requires further research.
AIM
To interpret data from the published literature on volatile organic compounds (VOC), including all the methods used to analyze exhaled breath in patients with IHD and heart failure.
METHODS
Searches for specific keywords were performed on Scopus and PubMed. A total of 20 studies were identified in breath analysis and IHD and heart failure. The study is registered in PROSPERO (Registration No. CRD42023470556).
RESULTS
Considering the articles found, more research is required to gain a full understanding of the role of VOCs in IHD and heart failure. However, the existing literature demonstrates that cardiac metabolic changes can be expressed in exhaled air. The number of papers found is extremely low, making interpretation extremely difficult.
CONCLUSION
Exhaled breath analysis can be a novel biomarker for the diagnosis and prevention of heart failure and IHD. Exhaled breath analysis can be used as a mirror to reflect the metabolic changes related to IHD and heart failure.
Red blood cell distribution width to albumin ratio is correlated with prognosis of patients in coronary care unit
Authors: Wang Jiao-Ni , Hu Ze-Song , Yu Yong-Wei , Peng Xiao-Hui 
Published: February 2025

BACKGROUND
As red blood cell distribution width (RDW) and albumin have been shown to be independent predictors of mortality from various diseases, this study aimed to investigate the effect of the RDW to albumin ratio (RA) as an independent predictor of the prognosis of patients admitted to the coronary care unit (CCU).
AIM
To use the RDW and albumin level to predict the prognosis of patients in the CCU.
METHODS
Data were obtained from the Medical Information Mart Intensive Care III database. The primary outcome was 365-day all-cause mortality, whereas the secondary outcomes were 30- and 90-day all-cause mortality, hospital length of stay (LOS), and CCU LOS. Cox proportional hazards regression model, propensity score matching, and receiver operating characteristic curve analyses were used.
RESULTS
The hazard ratio (95% confidence interval) of the upper tertile (RA > 4.66) was 1.62 (1.29 to 2.03) when compared with the reference (RA < 3.84) in 365-day all-cause mortality. This trend persisted after adjusting for demographic and clinical variables in the propensity score-matching analysis. Similar trends were observed for the secondary outcomes of hospital and CCU LOS. Receiver operating characteristic curve analysis was performed by combining the RA and sequential organ failure assessment (SOFA) scores, and the C-statistic was higher than that of the SOFA scores (0.733 vs 0.702, P < 0.001).
CONCLUSION
RA is an independent prognostic factor in patients admitted to the CCU. RA combined with the SOFA score can improve the predictive ability of the SOFA score. However, our results should be verified in future prospective studies.
Enhancing Rainwater Harvesting Sustainability in the Al-Basrah Basin, Iraq: A Two-Phased Approach Combining GIS-AHP for Site Suitability and Fog Computing for Dynamic Management
Authors: Najm Alauldeen Taher , Lee Wei-Koon , Abbas Abdulhussain Abdulkarim , Ramli Suzana 
Published: February 2025

The increasing issue of water scarcity worldwide calls for research into sustainable water management solutions. Using a two-phase methodology that makes use of geographic information systems (GIS) and analytical hierarchy process (AHP) method for multi-attributes decision making (MADM), integrated with fog computing. This study explores the potential of rainwater harvesting (RWH) in the Al-Basrah Basin, Iraq. In the first phase, weights are assigned to the evaluation attributes represented by the thematic layers (elevations, slope, river buffer, well pads/urban area, and soil texture). The results demonstrate the feasibility of the southeast region in the study area to be used for RWH. Furthermore, a comparison between AHP and the fuzzy analytic hierarchy process (FAHP), the merit of AHP to reconcile discrepancies and expedite the collection of expert opinions, reduces the problems of uncertainty and inconsistency, and improves the appropriateness assessment credibility and reliability. In addition, a novel conceptual second phase integrates fog computing for dynamic RWH management in the candidate RWH site area. At the selected RWH sites, fog nodes with sensors might be deployed to enable real-time data collection of rainfall, water quality, tank levels, and maintenance demands. Local preprocessing and analysis of data by fog nodes facilitate near-real-time decision-making for the best possible use of water resources and system health. Long-term water security in the Al-Basrah Basin may be enhanced by this strategy, which has the ability to enable informed water management.

Received: 27 September 2024 |Revised: 25 November 2024 |Accepted: 28 November 2024

Conflicts of Interest
The authors declare that they have no conflicts of interest to this work.

Data Availability Statement
Data available on request from the corresponding author upon reasonable request.

Author Contribution Statement
Alauldeen Taher Najm: Conceptualization, Methodology, Software, Validation, Formal analysis, Investigation, Writing – original draft, Visualization. Wei-Koon Lee: Resources, Data curation, Writing – review & editing, Supervision. Abdulhussain Abdulkarim Abbas: Validation, Formal analysis, Data curation. Suzana Ramli: Writing – review & editing, Supervision.
Anticancer Potential of Citrus Limon-Derived Purified Phytochemicals Using Their Implication in Progesterone and Estrogen Receptor-Dependent Breast Cancer
Authors: Nawaz Asad , Falak Sadia , Saqlain Muhammad , Abbas Mazhar , Haider Waqas , Zafar Maha Gul , Nadeem Marium , Farooq Ayesha 
Published: February 2025

Breast cancer one of the most common global health issues is influenced significantly by estrogen and progesterone signaling, with treatments often centered on endocrine-based regimens that include progesterone and estrogen modulators. Historically, a wide range of illnesses and ailments have been treated with medicinal herbs. The Rutaceae family’s Citrus limon contains a plethora of therapeutically valuable phytoconstituents: sugar, polyphenols, pectin, polysaccharides, and monoterpenes. Citrus peels exhibit a wide range of biological activities like antiviral, antibacterial, antifungal, anticancer, and antidiabetic most valuable ones. The current study was conducted to investigate the anticancer potential of phytoconstituents from Citrus limon against the breast cancer target proteins ERa (estrogen receptor alpha) and PR (progesterone receptor) using the technique of molecular docking after purification of phytochemicals. Drug likeliness was predicted using SwissADME while Molinspiration and PASS servers were used to estimate the bioactivity and anticancer activity of phytochemicals, respectively. Among seven phytoconstituents analyzed, humulene demonstrated the highest binding energy (−13.749 kcal/mol) against the targets of breast cancer. Phytochemicals complied with all ADME criteria and were verified as novel therapeutic agents. Humulene and valencene have the potential to treat breast cancer.

Received: 19 July 2024 | Revised: 5 November 2024 | Accepted: 30 January 2025

Conflicts of Interest
The authors declare that they have no conflicts of interest to this work.

Data Availability Statement
The data that support this work are available upon reasonable request to the corresponding author.

Author Contribution Statement
Asad Nawaz: Methodology, Writing – review & editing. Sadia Falak: Resources, Supervision, Project administration. Muhammad Saqlain: Formal analysis, Writing – review & editing. Mazhar Abbas: Conceptualization, Methodology, Resources, Data curation, Supervision, Project administration. Waqas Haider: Methodology, Software, Investigation, Writing – original draft, Visualization. Maha Gul Zafar: Validation, Writing – original draft, Writing – review & editing. Marium Nadeem: Validation, Writing – review & editing. Ayesha Farooq: Writing – original draft, Writing – review & editing.