bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Ultra-Reliable Quantum-Safe Software-Defined Deterministic Internet of Things (IoT) for Data-Centers, Cloud Computing and the Metaverse
Authors: Szymanski Ted 
Published: April 2023

<p>The next-generation Industrial and Tactile Internet of Things (IoT) will support smart Cyber-Physical Systems and Industry 4.0, including Smart Cities, and Industrial Automation. It will also support bandwidth-intensive applications, ie Data-Centers, Cloud Computing and the Metaverse. This paper explores ultra-high reliability and throughput in a "Software-Defined Deterministic Internet of Things". Multiple "Software-Defined Deterministic Wide Area Networks" (SDD-WANs) are introduced into layer 3, using simple "Deterministic Packet Switches" (D-switches). All complex functions are removed from layer-3 hardware, and are migrated into the SDN control-plane. The resulting D-switches can be fabricated on a single \emph{Integrated Circuit}, ie FPGA. To maximize reliability, mission-critical data is routed over multiple paths. A simple Forward Error Correcting (FEC) code transmits coded data over additional paths, to tolerate edge failures. This architecture offers many benefits: (a) "Ultra-High Reliability" is achieved, while reducing bandwidth costs; (b) "Ultra-High Throughput" is achieved, to support Data- Centers, Cloud Computing and the Metaverse; (c) The "bare-metal" D-switches use FPGAs to dramatically lower costs, with potential cost-savings reaching $1-2 Trillion (USD) over 2025...2030. (d) The lower costs address the IEEE's "Digital Divide", and can potentially improve Internet access for much of the world. (e) The Software-Defined-Networking (SDN) control-plane integrates Post-Quantum-Cryptography (PQC) and Artificial Intelligence (AI), and achieves ultra-secure Quantum-Safe communications, where each nation can achieve unprecedented protection of its critical infrastructure from external cyber-attackers.</p>
Навчально-виховна та творча робота в аматорському естрадному оркестрі
Authors: Филипчук Мирослав 
Published: April 2023

У запропонованій статті розкрито поняття навчально-виховної та творчої роботи, яка є вагомим складником репетиційного процесу й концертно-виконавської діяльності в аматорському естрадному колективі. Окреслено основні напрями навчально-виховної й творчої роботи у процесі вивчення оркестрових творів (засвоєння музично-теоретичних і естетичних знань; набуття музично-виконавських умінь і навичок), доведено, що ці напрями ґрунтуються на педагогічних принципах систематичності, доступності, послідовності, тісному зв’язку теоретичних знань та практичної діяльності. Наголошено, що важливу роль в аматорському естрадному оркестрі відіграє репертуар як основа творчого зростання учасників колективу.
Звернено увагу на те, що керівникові колективу у навчально-творчій діяльності відведена особлива роль – навчання учасників колективу практичним умінням та навичкам оркестрової гри, володіння творчими здібностями та психолого-педагогічними вміннями, формування в оркестрантів естетичних та художніх смаків, ідеалів, почуттів тощо; підбору та збагачення репертуару новими художньо досконалими творами (інструментальними, естрадними, джазовими, вокальними, сучасними, народними та ін.).
Внесок Василя Пачовського у розвиток літературної казки на закарпатті (20-30 роки ХХ століття)
Authors: Лемак Оксана 
Published: April 2023

У статті представлено аналіз доробку українського письменника і педагога Підкарпатської Русі Василя Пачовського у царині літературної казки щодо визначення її дидактичного та виховного потенціалу і внеску в розвиток національного казкарства. Означені матеріали актуалізують можливість використання творчого доробку письменника в освітньому процесі та розвитку читацької культури дітей і молоді.
Окреслено ідейну спрямованість та виховний потенціал таких написаних В. Пачовським творів, як: «Скарб руської землі», віршованої казка, в основу сюжетної лінії якої покладено оповідь старого рибалки про захований на дні річки безцінний скарб – української мови і культури, який нащадки мають свято зберігати; «Сріберний дзвін», поеми-казки, що передає ідею соборності України через синтез історії перебування Закарпаття у складі Київської Русі, та легенди про збережений із тих часів срібний дзвін; «Золота Гвіздка», віршованої казка для дітей, яка на основі фольклорних джерел передає інтригу боротьби між силами Добра і Зла; «Про князя Коріятовича і жовтого змія Веремія», прозової казки, що приваблює юного читача прив’язкою до рідного краю, де розгорталася епічна драма двобою з чудовиськом; «Тріє царі», казково-фантастичої поезії, в сюжетній ліній якої переплелися історично віддалені легендарні постаті Закарпаття, що уособлюють різні періоди визвольної боротьби; «Князь Ляборець. Міт Срібної Землі», епічної поеми- казки, яка приваблює читача ретроспективою драматичної баталістики та відображає знакові події тисячолітньої історії Закарпаття.
Impact of the Covid-19 pandemic on air transport
Authors: Filipiak Dariusz , Matyjaszkiewicz Magdalena , Zalewski Piotr , Postek Joanna 
Published: April 2023

ObjectivesThe purpose of this article is to present the impact of the Covid-19 pandemic on the operation of airlines and the aviation sector as a whole. The pandemic forced airlines to make many changes in their operations and greatly affected the entire aviation sector. The operation of the aviation sector during the pandemic period was affected by the administrative closure of flights for months, as well as the regulation banning flights to selected countries.MethodsThe study used the method of analyzing statistical data and reports on the aviation sector. The method of analyzing statistical data made it possible to compare data from the aviation sector on, among other things, the number of passengers carried, and the number of flights made.ResultsAs a result of the development of the Covid-19 pandemic, the aviation sector reduced the number of flights operated, which contributed to a decline in the number of passengers carried and heavy losses for the sector. During the pandemic period, the growth of airlines was sharply halted.ConclusionsAviation around the world operated for several months in a completely new and highly unpredictable reality. The crisis caused by the Covid-19 pandemic is the biggest crisis in aviation history. The sector needs to define clear rules and messages in crisis situations.
Datenbasierte Gestaltung nachhaltiger Produktionsnetzwerke/Data-driven design of sustainable production networks
Authors: Schuh Günther , Schmitz Seth , Schlosser X. Tino , Janssen Benedict 
Published: April 2023

Während die Gestaltung globaler Produktionsnetzwerke in den vergangenen Jahrzehnten hauptsächlich an den Zieldimensionen Kosten, Geschwindigkeit und Flexibilität ausgerichtet war, gewinnt die ökologischen Nachhaltigkeit als weitere Zieldimension zunehmend an Bedeutung. Gepaart mit einer steigenden Dynamik im Umfeld produzierender Unternehmen, ist eine transparente, datenbasierte Netzwerkgestaltung essenziell, um erfolgreich zu sein. Dieser Beitrag präsentiert ein datengetriebenes Vorgehen mithilfe des Softwaretools „Miori“ Network Design, das die Gestaltung des Produktionsnetzwerkes sowohl unter klassischen Zieldimensionen, als auch unter Nachhaltigkeitsdimensionen erlaubt.

While the design of global production networks in the past decades was mainly oriented towards the target dimensions of costs, speed and flexibility, ecological sustainability is becoming increasingly important as a further target dimension. Coupled with an increasing dynamic in the environment of manufacturing companies, a transparent, data-based network design is essential to be successful. This paper presents a data-driven approach with the help of the software tool Miori Network Design, which enables the design of the production network according to both classical and sustainability dimensions.
Datendurchgängige Fabrik/A blue print for factory planning – Data consistent factory
Authors: Ihnen Deike , Lange Annika , Knothe Thomas 
Published: April 2023

Das Blue Print Plant Model ist ein integriertes Unternehmensmodell, welches Objekte und deren Parameter einer Fabrik mit Prozessen sowie den Berechnungs- und Auslegungsverfahren verbindet. Dabei werden Partikularmodelle, wie zum Beispiel Wirtschaftlichkeitsanalysen, flexibel eingebunden. Die integrierte Betrachtung unterstützt eine Datendurchgängigkeit, mit der sich Medienbrüche entlang der Planungsphasen reduzieren lassen. Im Beitrag werden Erfahrungen anhand eines Use Cases der diskreten Fertigung dargestellt.

The Blue Print Plant Model is an integrated enterprise model that links objects and their parameters of a factory with processes, calculation and design procedures. Particular models, such as profitability analyses, are flexibly integrated. The integrated view supports data consistency, which reduces discontinuities along the planning phases. The article presents experiences based on a use case of discrete manufacturing.
Digitale und optimierte Produktionslinienplanung/Automation in factory and production planning – Digital and optimized production line planning
Authors: Öfele Marcel , Häckel Björn , Braunreuther Stefan , Hartmann Christoph , Willburger Lukas , Spindler Klaus 
Published: April 2023

Bei der Fabrikplanung ist die Produktionslinienplanung von hoher Komplexität geprägt und mit herkömmlichen Methoden nicht zufriedenstellend lösbar. Das Problem lebt im hochdimensionalen Raum und muss dort gelöst werden. Dieser repräsentiert die Eigenschaften der Produkte, zugehörige Produktionsprozesse und betriebswirtschaftliche Aspekte. Es wird ein Konzept zur automatisierten Linienplanung inklusive der Montagereihenfolgeplanung, Werksauswahl, Liniengestaltung und Werkerzuordnung vorgestellt.

In factory planning, production line planning is characterized by a high complexity and cannot be solved satisfactorily with conventional methods. The problem lives in a high-dimensional space and must be solved there. This space represents the characteristics of the products, associated production processes and business aspects. A concept for automated line planning including assembly sequence planning, plant selection, line layout and worker assignment is presented.
Herausforderungen der personalisierten Produktion/Challenges for personalized production – Expert interviews on personalization in the DACH region
Authors: Bauernhansl Thomas , Gross Erwin , Mais Franziska , Schrader Peter , Briem Ann-Kathrin , Dangelmaier Manfred , Hildebrandt Nadja , Krieg Sabine , Ulmer Janina 
Published: April 2023

Die zunehmende Individualisierung von Produkten stellt Unternehmen vor neue Herausforderungen. Haupttreiber sind hierbei kundenindividuelle Produkte, die in kleinen Stückzahlen aber zu Kosten einer Großserienfertigung produziert werden sollen. In einer Praxisstudie des Leistungszentrums „Mass Personalization“ in Stuttgart wurden vor diesem Hintergrund Unternehmen in der DACH-Region zu ihrem Personalisierungsgrad sowie den Herausforderungen und Hemmnissen der Personalisierung von Produkten befragt. Eine Erkenntnis ist, dass Unternehmen Personalisierung zur Differenzierung am Markt nutzen, um Kunden passgenauere Produkte anbieten zu können – das Ziel ist es Wettbewerbsvorteile auszubauen.

Due to increasing product individualization, companies face new challenges. The main drivers are customized products produced in small quantities but at the cost of large-scale production. In a practical study conducted by the Center for Mass Personalization in Stuttgart, companies in the DACH region were asked about their degree of personalization and the challenges and obstacles they face personalizing on of products. One finding is that companies use personalization for differentiation in the market so that they can offer customers more suitable products – the goal is to expand competitive advantages.
The Evolution of Activity and Chemical Composition in Rosetta’s Comet Targets across Multiple Apparitions: Complications for CS2 as the CS Parent in Comet Nuclei
Authors: Noonan John W. , Parker Joel Wm. , Harris Walter M. , Bromley Steven , Saki Mohammad , Moulane Youssef , Farnocchia Davide , Micheli Marco , Li 李 Jian-Yang 荐扬 , Mandt Kathleen E. , Venkataramani Kumar , Bodewits Dennis 
Published: April 2023

Abstract
Jupiter-family comets are ephemeral small bodies injected into the inner solar system from the Kuiper Belt, doomed to either sublimate all their volatiles and become inert or violently shatter from the activity. We investigate two target candidates of the ESA Rosetta mission, comets 46P/Wirtanen and 67P/Churyumov-Gerasimenko, which had favorable apparitions for Earth-based observations in 2018–2019 and 2021, respectively. Using the Hubble Space Telescope STIS and COS instruments, we observed OH and CS emissions to characterize production rates of H2O and CS, established Af
ρ values, and placed upper limits on the production rate of C2 and its parent. We find CS/H2O relative abundances that are significantly (5σ–7σ) larger than previous remote near-UV (NUV) measurements of 46P and 67P at similar heliocentric distances and CS/H2O values larger than those obtained via contemporaneous submillimeter observations for the same apparitions. We also find that for 67P the remote derivations of CS2/H2O ratios are substantially (∼50×) higher than the values measured by the ROSINA mass spectrometer on board the Rosetta spacecraft for all NUV-derived CS2 production rates. The discrepancy points toward an unidentified CS parent or parents with contributing factors from uncertainties with the fluorescence efficiencies of the CS (0,0) band of the A
1Π–X
1Σ+ system around 2580 Å. Given the significance of understanding the chemistry and dissociation physics of sulfur-bearing molecules in comets for tracing planetesimal formation environments, as well as the limited studies in this area, we propose several hypotheses to explain this discrepancy and outline future studies to address these issues.
Comparative analysis of cytocompatible properties of the root surface exposed to diode laser (970 nm) as adjunct to scaling and root planing
Authors: Savita A M , Nageswaran G R , Reddy Roopa 
Published: April 2023

Aims:
The aim of the current study was to examine the effects of diode laser (970 nm) when used as adjunct to mechanical debridement on reattachment of fibroblast cell cultures to the root surface.

Materials and Methods:
Eighteen extracted single-rooted human teeth were used in the study. Briefly, the anatomical crowns were removed; roots were sectioned and preserved in antiseptic solution. The sections were divided into three groups: (i) scaling and root planing (SRP), (ii) SRP followed by diode laser exposure and (iii) untreated control group. All the sections were inoculated with NIH 3T3 mouse fibroblast cell lines and cell attachment was confirmed by scanning electron microscopy analysis and growth was quantitatively assessed by MTT assay after days 1, 3 and 5.

Results:
On intragroup analysis, there was significant cell proliferation seen on day 1 and day 5. However, no significant differences were observed between the treatment groups at the various time points.

Conclusion:
970-nm diode laser exposure had a positive effect in enhancing the fibroblast reattachment to root surfaces. However, to ascertain the role of laser treatment in enhancing the rapid cell growth compared to SRP, further quantitative studies with more sample numbers are required.
Cedarwood oil as an alternative to xylene as a clearing agent in histopathological tissue processing – A comparative study
Authors: Thamilselvan Snega , Sherlin Herald J. , Jayaraj Gifrina , Don K. R. , Santhanam Archana 
Published: April 2023

Background:
Clearing in histopathological tissue processing should be able to make the tissues translucent and clear for the tissues to be visible under light microscopy and should render the clearing agent to be miscible with the dehydrant and the impregnation wax in the preceding and following processing steps. Xylene is a gold standard clearing agent but increasing concerns about the potential carcinogenicity, implementing eco-friendly agents in routine histopathology is necessary.

Aim:
The aim of the study is to assess the clearing ability of Cedarwood oil as an alternative to Xylene in routine tissue processing.

Materials & Methods:
The study was carried out in the Department of Oral Pathology and Microbiology. Formalin fixed 50 tissue samples of size 3-7mm were taken and subsequent dehydration done with acetone and alcohol. The dehydrated tissue is later processed using 90ml of Cedarwood oil with few drops of Xylene and Thymol. After clearing the tissues were subjected to impregnation and embedded in paraffin wax, later which sections were made and stained using H & E stain.

Results:
The results of our study on comparison showed better outcome in tissues processed with cedarwood oil than xylene. Statistical Significant correlation was observed in nuclear staining (p value = 0.001) ; cytoplasmic staining (p value = 0.08) and background staining (p value = 0.045) indicating a positive results on using cedarwood oil as clearing agent.

Conclusion:
The cedarwood oil can be considered as a safer natural alternative to xylene in laboratories. The cedarwood oil is eco - friendly and easily available with enhanced tissue processing qualities.
In vitro anticancer activity of a pentacyclic triterpenoid via the mitochondrial pathway in bone-invasive oral squamous cell carcinoma
Authors: Adtani Pooja Narain , Narasimhan Malathi , Girija Dinesh M. 
Published: April 2023

Context:
Oral cancer is the most dreadful cancer worldwide with a 5-year survival rate of approximately 50%. Anticancer therapies such as chemotherapy and radiotherapy result in severe side effects.

Aim:
We aimed to evaluate the in vitro anticancer activity of Asiatic acid (AA) on bone-invasive oral squamous cell carcinoma (BHY) cell line.

Settings and Design:
This was an in vitro laboratory setting.

Materials and Methods:
BHY cell lines were used for the experiment. Confocal microscopy was used to observe cellular alterations. 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay was performed to determine the IC50 concentration of AA and flow cytometry to analyze the percentage of cells in each phase of the cell cycle post treatment. Immunoblot assays and semiquantitative reverse transcriptase-polymerase chain reaction (rt-PCR) were used to study the expression level of genes involved.

Statistical Analysis Used:
Student's t-test and one-way analysis of variance were used for statistical analysis.

Results:
IC50 concentration of AA was 15.6 μM. On flow cytometry analysis, treatment with 15.6 μM and 31.25 μM of AA for 24 h increased the percentage of cells in the G2/M phase to 45.63% and 53.12%, respectively, compared to 9.62% in control group. Immunoblot analysis and semiquantitative rt-PCR demonstrated an upregulation of p53, cyclin-dependent kinase inhibitors (p21 and p27), caspase-3, caspase-9, cytochrome c and Bax in a time-dependent manner and downregulation of cyclins and anti-apoptotic protein Bcl-2 (**P < 0.05, ***P < 0.001 versus control) post AA treatment.

Conclusion:
AA induces apoptosis via the mitochondrial-dependent pathway and causes cell cycle arrest at the G2/M phase in BHY cell line.
Comparison of orosomucoid-1 immunoexpression and angiogenesis between oral squamous cell carcinoma cases with different histological grades
Authors: Sánchez-Romero Celeste , Bologna-Molina Ronell , González-González Rogelio , Salazar-Rodríguez Sirced , Mendoza Nataly Barreiro 
Published: April 2023

Background:
Oral squamous cell carcinoma (OSCC) is the most common malignancy in this region, and thus, further elucidation of its tumoral mechanisms is important. One of the main roles of the acute-phase protein orosomucoid-1 (ORM1) is the promotion of angiogenesis, which is key for tumor nutrition and growth.

Aim:
Our aim was to evaluate the immunohistochemical expression of ORM1 and the angiogenic activity indicated by microvascular density (MVD) in OSCC samples according to histological grade.

Materials and Methods:
Formalin-fixed, paraffin-embedded sections from 45 OSCC cases were submitted to immunohistochemistry: 25 were well-differentiated OSCC, 18 were moderately differentiated OSCC and 2 were poorly differentiated OSCC. ORM1 staining was evaluated by a semiquantitative method, and CD34-positive blood vessels were quantified to calculate the MVD. The results were statically analyzed.

Results:
All cases exhibited immunoexpression of ORM1 and CD34. However, no significant differences were found between the expression of both markers among the histological grades. In addition, the presence of ORM1 in inflammatory cells and in the extracellular matrix was detected in most cases.

Conclusion:
These results suggest that the induction of angiogenesis is not the main role of ORM1 in OSCC and may be associated with the regulation of the immune/inflammatory response or the transport of protumoral molecules, such as sialyl-Lewis X or phorbol esters, which requires confirmation in future studies.
The temporomandibular joints disorders in patients with osteoporosis
Authors: Lilo Lilo Ali Qays , Ali Maytham Riad , Hussein Alyassiri Ali Mihsen 
Published: April 2023

Background:
Osteoporosis is a skeletal and progressive behavioral disease with physically and psychologically significant consequences.

Aims of the Study:
Evaluate the presence and effects of Temporomandibular Joints Disorders in osteoporotic patients.

Materials and Methods:
Fifty-eight (58) patients with osteoporosis participated in this study as they were already diagnosed by Rheumatologists, physical and sport Rehabilitation physicians in Merjan Medical city/Babylon – Iraq between period February and August 2019.

Results:
Twenty-seven (27) patients with T. M. J clicking as anterior disk displacements, Seventeen (17) patients with spasm in muscles of mastication, and then finally Fourteen (14) out of 58 patients with subluxation and dislocation.

Conclusions:
Osteoporosis can have a significant impact on oral health.
Repair strength of dimethacrylate-based composites resins: Effect of sandblasting, adhesive bonding, and thermocycling
Authors: Khoroushi Maryam , Bahrani Mohammad Mehdi , Zandian Amin , Fathpour Kamyar 
Published: April 2023

Background:
The goal of this study is to determine the effect of different sandblasting particles and dental adhesive systems on the repair strength of dimethacrylate-based composite resins.

Materials and Methods:
In this in-vitro study, 96 specimens of X-trafil composite blocks were prepared and divided into eight groups (n = 12). Four groups were sandblasted with Aluminum Oxide (AL) and four other groups with Bio-Active Glass particles (BAG). A two-component silane was applied on the surface of all the samples after phosphoric acid etching and rinsing. Two groups of the sandblasted specimens were treated with Clearfil SE Bond (CSB) and the other two groups were treated with Single Bond Universal (SBU) and new composite was bonded to the prepared surfaces. Half of the specimens in each group were thermocycled. Shear force was applied to the bonded composite using a universal testing machine with a crosshead speed of 0.5 mm/min and mean shear bond strength (MSBS) was calculated (MPa). The data was analyzed using Kruskal–Wallis and Man–Whitney U-tests with the significance level of 0.05.

Results:
Significant differences were observed between different groups (P < 0.001). The highest and the lowest MSBS of the thermocycled samples were reported 18.88 MPa with application of AL and SBU and 11.46 MPa with the application of AL and CSB, respectively. No significant difference was observed with application of BAG particles after thermocycling.

Conclusion:
Effect of AL on repair shear bond strength of composite resins is affected by bonding type. Bonding type did not affect repair shear bond strength of BAG. Thermocycling reduced bond strength in all groups.