bluuebunny/crossref_metadata_2025_split huggingface dataset:
Kajian Molekuler Ikan Sembilang (Neosilurus sp.) di Perairan Rawa Padi Kabupaten Merauke
Authors: Saleky Dandi , Siruru Meyani Anjelita , Sunarni Sunarni , Pangaribuan Rosa Delima 
Published: January 2025

Sembilang is one of the fish that is abundant in Merauke mainland waters. Genetic research needs to be done to prevent the decline of catfish population. DNA barcoding is a taxonomic method that uses short genetic markers in an organism's DNA to identify species. This research aims to identify the Sembilang fish species using the Cytochrome Oxidase I gene. This study is an exploratory survey research. Sample collection was carried out in the waters of Padi Swamp, Merauke Regency. The mitochondrial cytochrome oxidase I (COI) gene was amplified using the Polymerase Chain Reaction (PCR) method with FISH-BCL and FISH-BCH primers. The results of analysis using DNA barcoding revealed that the samples collected were the Sembilang species (Neosilurus ater) with a DNA sequence length of 660 bp. Phylogenetic reconstruction using the Neighbor-Joining method with the 2-Parameter Kimura Model shows sequence grouping based on similarity and genetic distance between species.
Documentary Video Media Development on Food Additives
Authors: Sabdaningtyas Katherina , Hairida Hairida , Rasmawan Rahmat , Masriani Masriani , Hadi Lukman 
Published: January 2025

In this era, technology is advancing and developing rapidly. Almost every minute or even second we are in direct contact with technology. In today's world of education, it is also inseparable from the role of technology. Students who on average have good technological literacy tend to get bored more quickly when learning runs conventionally. Regarding the function of learning media, it can be emphasized as follows: as a tool to streamline learning, accelerate the teaching and learning process, and improve the quality of the teaching and learning process. The purpose of this research is to produce a documentary video about food additives that is expected to be utilized for ease of learning. The method used in this research is research and development developed by Borg and Gall. This documentary video media development procedure goes through stages, namely: (1) Research and information gathering, (2) Product development planning, and (3) Initial Product Development. Data or information collection techniques using literature studies and field studies. Stages of video development by creating a storyboard using a video editor application. The next stage of learning videos is validated or evaluated by experts. This Documentary Video validation analysis uses descriptive methods through questionnaires. The results of the validation of this Documentary Video obtained an average score of 3.5 by entering the valid category. It can be concluded that this Video Documentary is suitable for use and can be followed up by looking at student responses.
Review of Secondary Metabolites From Melandean Bark Extract (Bridellia Micrantha): Bioactive Potential and Applications in Health
Authors: Bayani Faizul , Muhali Muhali , Yuliana Devi , Hulyadi Hulyadi , Gargazi Gargazi 
Published: January 2025

Abstract The emergence of various diseases affecting the immune system, such as COVID-19 and Hand, Foot, and Mouth Disease, demands serious attention. Current climate changes occurring in almost all parts of the world can lead to the emergence of various viruses and bacteria that cause multiple diseases. Exploring medicinal plants that can enhance the immune system is crucial to be continued. This study aims to identify secondary metabolite compounds contained in Bridellia Micrantha plants using chemical reagents and gas chromatography-mass spectrometry (GC-MS) instruments. This research is an experimental laboratory study. The variable studied is the content of secondary metabolite compounds. Data were collected using chemical reagents and instruments. The obtained data are described in informative tables and graphs. Based on the identification results using instruments, positive results were found for organic compound groups such as flavonoids, alkaloids, and tannins. GC-MS test results showed that the organic compounds contained in Bridellia Micrantha extract are 43.05% hexadecanoic acid, 21.46% oleic acid, 16% docos-13-enoic acid, 3.89% octadecanal, 1.85% propanediol, and 0.91% trans-phytol. Literature reviews indicate that the organic acids in Bridellia micrantha extract have clinical activities as antioxidants and anti-inflammatory agents, while organic compounds containing hydroxyl groups have clinical activities as anti-cancer agents. Based on these findings, Bridellia micrantha extract has the potential as a medicine that can enhance the body's immunity.
Developing STREAM Based Pancasila Student Profile Strengthening Project (P5) Module on Chemical Bond Lesson
Authors: Khumairoh Nurul , Okmarisa Heppy , Refelita Fitri , Mahartika Ira 
Published: January 2025

The implementation of Merdeka curriculum has not long been established as the national curriculum, so many schools still lack teaching materials with limited textbooks. This research aimed at developing STREAM (Science, Technology, Religion, Engineering, Art, and Mathematics) based Pancasila student profile strengthening project module on Chemical Bond lesson, and it was conducted with validity test by media and material experts, teacher practicality test, and student response test. Research and Development (RnD) method was used in this research with Design and Development Research (DDR). This research was conducted at State Senior High Schools 14 and 1 Pekanbaru. The research findings showed that the validity scores were 82.6% by media experts with very valid category and 87.45% by material experts with very valid category. The result of teacher practicality test showed that the mean was 93.84%, and it was on very practical category. The last test was student response test, the result was 83.58%, and it was on very valid category. The research findings showed that STREAM-based P5 teaching module developed was very valid, practical, and interesting for students.
Impact of the external knee flexion moment on patello-femoral loading derived from in vivo loads and kinematics
Authors: Trepczynski Adam , Kneifel Paul , Heyland Mark , Leskovar Marko , Moewis Philippe , Damm Philipp , Taylor William R. , Zachow Stefan , Duda Georg N. 
Published: January 2025

IntroductionAnterior knee pain and other patello-femoral (PF) complications frequently limit the success of total knee arthroplasty as the final treatment of end stage osteoarthritis. However, knowledge about the in-vivo loading conditions at the PF joint remains limited, as no direct measurements are available. We hypothesised that the external knee flexion moment (EFM) is highly predictive of the PF contact forces during activities with substantial flexion of the loaded knee.Materials and methodsSix patients (65–80 years, 67–101 kg) with total knee arthroplasty (TKA) performed two activities of daily living: sit-stand-sit and squat. Tibio-femoral (TF) contact forces were measured in vivo using instrumented tibial components, while synchronously internal TF and PF kinematics were captured with mobile fluoroscopy. The measurements were used to compute PF contact forces using patient specific musculoskeletal models. The relationship between the EFM and the PF contact force was quantified using linear regression.ResultsMean peak TF contact forces of 1.97–3.24 times body weight (BW) were found while peak PF forces reached 1.75 to 3.29 times body weight (BW). The peak EFM ranged from 3.2 to 5.9 %BW times body height, and was a good predictor of the PF contact force (R2 = 0.95 and 0.88 for sit-stand-sit and squat, respectively).DiscussionThe novel combination of in vivo TF contact forces and internal patellar kinematics enabled a reliable assessment of PF contact forces. The results of the regression analysis suggest that PF forces can be estimated based solely on the EFM from quantitative gait analysis. Our study also demonstrates the relevance of PF contact forces, which reach magnitudes similar to TF forces during activities of daily living.
Reproducible research policies and software/data management in scientific computing journals: a survey, discussion, and perspectives
Authors: Hernandez Jose Armando , Colom Miguel 
Published: January 2025

IntroductionThe recognized credibility crisis in scientific research has led to an increasing focus on reproducibility studies, particularly in computer science. Existing studies predominantly examine specific technological aspects of reproducibility but neglect the critical interplay between authors and publishers in enabling reproducible computational scientific research.MethodsA systematic review was conducted following the PRISMA Literature Review methodology, complemented by a Journals Survey. This approach enabled a comprehensive analysis of reproducibility policies and software/data management practices in scientific computing journals.ResultsThe survey revealed significant variability in reproducibility policies and practices across computer science journals. Many gaps and challenges were identified, including inconsistencies in policy enforcement, lack of standardized tools, and insufficient recognition of software as a research artifact. The analysis highlighted the potential of Reproducibility as a Service (RaaS) as an innovative solution to address these challenges.DiscussionThis study underscores the need for improved standardization and implementation of reproducibility policies. Strategies to enhance reproducibility include fostering collaboration among authors, publishers, and technology providers, as well as recognizing software as a critical research output. The findings aim to guide stakeholders in bridging the current gaps and advancing the reproducibility of computational scientific articles.
Enhancing heart and circulatory well-being through optimized radial artery techniques: a meta-analysis of hemostasis and patient comfort
Authors: Yang Yanru , Zhu Hongyan , Zai Guangyao 
Published: January 2025

ObjectiveThis meta-analysis elucidates the efficacy of the Transradial Band Device (TR Band) in minimizing complications like radial artery occlusion and hematoma, preserving heart health, and enhancing blood flow post-transradial catheterization.MethodsA comprehensive literature search across databases including PubMed, Cochrane, and Embase examined the impact of radial artery compression techniques and decompression times on complications. Data from 13 studies were analyzed using R 4.1.2 with fixed-effects and random-effects models. The Newcastle-Ottawa Scale assessed the risk of bias in observational cohort studies.ResultsIn our meta-analysis, we evaluated data from various studies encompassing different air volumes in transradial band devices across several outcomes including bleeding, hematoma, radial artery occlusion (RAO), Visual Analog Scale (VAS) scores, and compression time. The collective analysis integrated findings from 11 studies, totaling 4,679 patients. No significant difference in bleeding risk (OR 1.04, 95% CI 0.60–1.82, p &gt; 0.05, I2 = 78%), hematoma incidence (OR 0.96, 95% CI 0.78–1.19, p &gt; 0.05, I2 = 0%), or RAO incidence (OR 0.96, 95% CI 0.78–1.19, p &gt; 0.05, I2 = 0%) was observed between the “Less air” and “15 ml air” groups. However, the “Less air” group reported significantly higher VAS scores indicating increased pain or discomfort (Mean Difference 0.25, 95% CI 0.09–0.41, p &lt; 0.05, I2 = 0%). Compression time analyses showed no significant difference between groups (Mean Difference −17.73, 95% CI −54.65–19.20, p &gt; 0.05, I2 = 99%). Sensitivity analyses confirmed the stability of these findings, and Egger's test indicated no significant publication bias across the outcomes. This synthesis highlights the nuanced impact of air volume adjustments in transradial bands on patient outcomes, emphasizing the necessity for further research and standardized protocols to optimize patient safety and comfort post-intervention.ConclusionThe TR Band, when utilized with optimized air volume/pressure, maintains an essential balance between ensuring hemostasis and enhancing patient comfort without elevating the risk of radial artery complications. These findings support the careful selection of TR Band settings to optimize clinical outcomes in patients undergoing transradial cardiac procedures. Further research is warranted to establish standardized guidelines for the most effective use of TR Band in various clinical scenarios.
Global burden of cardiovascular diseases attributable to diet low in vegetables from 1990 to 2021 and forecasting the future trends: a population-based study
Authors: Mao Qingsong , Kong Yuzhe 
Published: January 2025

BackgroundThis investigation examines the worldwide impact of cardiovascular diseases (CVD) resulting from inadequate vegetable consumption, based on the 2021 Global Burden of Disease Study data.MethodThe study assessed the global, regional, and national repercussions of low vegetable intake on CVD, with a focus on variations among different age and gender demographics. It further analyzed the correlation between disease burden and the Socio-Demographic Index (SDI), and employed an ARIMA model to predict future trends in CVD associated with insufficient vegetable consumption up to 2050.ResultIn 2021, a diet lacking in vegetables was responsible for roughly 682,400 deaths and 16 million disability-adjusted life years (DALYs) attributed to CVD, indicating a declining pattern over recent year. Individuals aged 75 and older were predominantly affected. Future projections indicate an expected rise in CVD incidence in lower-middle SDI regions, with African nations potentially experiencing increased challenges related to low vegetable consumption by 2030 and 2050.ConclusionThe findings underscore the critical necessity for preventive measures against CVD and emphasize the significance of improving dietary habits, particularly vegetable intake.
Evaluation of Upper Paleozoic source rocks in the southeastern margin of the Ordos Basin
Authors: Wan Yongping , Wang Zhenchuan , Cui Minrui , Liu Kouqi , Li Wu 
Published: January 2025

IntroductionThe Yanchang gas field in the southeastern Ordos Basin is an important region for natural gas exploration due to the presence of Upper Paleozoic coal-bearing source rocks. This study systematically evaluates these source rocks in terms of organic matter abundance, type, and thermal maturity to assess their hydrocarbon generation potential.MethodsOrganic geochemical analyses were performed to determine the total organic carbon (TOC) content, kerogen type, and thermal maturity of the source rocks. The Benxi and Taiyuan Formations were specifically targeted for detailed evaluation. Kerogen maceral analysis was used to classify organic matter types, while thermal maturity was assessed through vitrinite reflectance (Ro) values.ResultsThe results indicate that the Upper Paleozoic source rocks exhibit high TOC content, with the Benxi and Taiyuan Formations showing excellent hydrocarbon generation potential. Kerogen maceral analysis identified predominantly Type III (humic) kerogen with some Type II2 (humic-sapropelic) components, suggesting a strong capacity for gas generation. Thermal maturity analysis revealed that the source rocks have reached the overmature dry gas stage, signifying advanced thermal evolution.DiscussionThe findings highlight the central and southern parts of the Yanchang gas field as promising exploration targets, characterized by high TOC content, favorable kerogen type indices, and high Ro values. These features collectively demonstrate the significant hydrocarbon generation potential of the Upper Paleozoic source rocks.ConclusionThe Upper Paleozoic coal-bearing source rocks in the Yanchang gas field represent a highly prospective target for natural gas exploration, particularly in regions with favorable organic geochemical properties.
Causal relationships between plasma lipidome and diabetic neuropathy: a Mendelian randomization study
Authors: Wang Zhaoxiang , Liu Zhong , Yang Qichao , Qiao Huibo , Yin Yong , Zhao Zhiyong , Shao Xuejing 
Published: January 2025

BackgroundDyslipidemia is closely related to diabetic neuropathy. This study examined the potential causal relationship involving 179 lipid species and the disease.MethodsThe pooled data on 179 lipid species and diabetic neuropathy were obtained from previous genome-wide association studies (GWAS). A Mendelian Randomization (MR) method was employed to investigate the potential causal link, and the robustness of the findings was confirmed through comprehensive sensitivity analyses.ResultsGenetically, phosphatidylcholine might be associated with the risk of diabetic neuropathy. Upon adjusting for multiple comparisons, higher levels of phosphatidylcholine (16:0_20:2) (OR = 0.82, 95%CI: 0.73-0.91; P &lt; 0.001, FDR = 0.033) and phosphatidylcholine (16:1_18:1) (OR = 0.77, 95%CI: 0.67-0.88; P &lt; 0.001, FDR = 0.019) are associated with a decreased risk of diabetic neuropathy. Further multivariable MR (MVMR) analysis demonstrated the effect of genetically predicted phosphatidylcholine (16:1_18:1) remained after adjusting for body mass index (BMI) and glycated hemoglobin (HbA1c). Sensitivity assessments have confirmed the robustness of these findings, revealing no evidence of heterogeneity or pleiotropy.ConclusionOur research linked certain lipid species with diabetic neuropathy risk, suggesting that targeting lipids could be a therapeutic strategy in clinical trials addressing this condition.
The relationship between C-reactive protein to lymphocyte ratio and the prevalence of chronic kidney disease in US adults: a cross-sectional study
Authors: He Pengfei , Zhang Jiao , Tian Ni , Deng Yuanyuan , Zhou Min , Tang Cheng , Ma Yu , Zhang Mianzhi 
Published: January 2025

ObjectiveThe C-reactive protein/Lymphocyte Ratio (CLR) is a novel biomarker whose role in the development of chronic kidney disease (CKD) is not well understood. This study aimed to investigate the correlation between CLR and the prevalence of CKD.MethodsThis cross-sectional study included participants from the US National Health and Nutrition Examination Survey conducted between 1999 and 2010. Multivariate regression analyses and subgroup analyses were performed, controlling for socio-demographic variables, lifestyle behaviors, chronic diseases associated with kidney disease, and biochemical markers of bone metabolism. The associations between CLR and CKD prevalence, as well as indicators of renal damage, were explored. Non-linear relationships were analyzed using weighted restricted cubic splines. The predictive ability of CLR for CKD was assessed by the receiver operating characteristic curve and the area under the curve was calculated. Subgroup and sensitivity analyses were conducted to validate the robustness of the model.ResultsA total of 13,862 respondents were included, comprising 2,449 CKD patients and 11,413 non-CKD patients. Weighted logistic regression modeling revealed a positive correlation between CLR levels and CKD prevalence (Odds ratio [OR] = 1.54, 95% Confidence interval [CI] = 1.30 to 1.83, P &lt; 0.001). Additionally, CLR levels were negatively correlated with the glomerular filtration rate, a marker of renal injury, and positively correlated with the urinary albumin/creatinine ratio. The receiver operating characteristic curve demonstrated that the area under the curve for CLR in predicting CKD was 0.653 (95% CI, 0.641–0.665). The optimal cutoff value was 0.856, with a sensitivity of 0.703, specificity of 0.526, positive predictive value of 0.874, and negative predictive value of 0.275. The robustness of the model was confirmed through subgroup and sensitivity analyses.ConclusionAnalysis of a large cross-sectional dataset demonstrated a positive correlation between CLR levels and CKD prevalence, suggesting that CLR may serve as a novel marker for the development and treatment of CKD.
Clean energy development and low-carbon transition in China’s power industry
Authors: Cai Yuxuan , Loi Edmund HoiNgan , Tung Chih-Lin , Wang Hao , Zheng Jiansong 
Published: January 2025

IntroductionChina is the largest emitter of carbon dioxide (CO2) in the world, with its power industry being the primary source of these emissions. The high emission levels are primarily attributed to the extensive consumption of fossil resources during thermal power generation. Developing clean energy power generation to replace thermal power generation is one of the main strategies to mitigate the high level of carbon emissions in the power industry and thus promoting its low-carbon transition.MethodTo explore the relationship between China’s development level of clean electricity and carbon emissions from thermal power, this paper conducts an empirical study using provincial data from 2008 to 2021, while employing fixed-effects models, mediation effect tests, and heterogeneity tests.Results and discussionThe results indicate that an increase in the level of clean electricity development reduces CO2 emissions from thermal power, and this effect exhibits a trend of diminishing from the eastern economic zone to the western economic zone in China. In the eastern regions with higher levels of urbanization, the development of clean electricity has a more significant effect on mitigating CO2 emissions from thermal power, whereas upgrading industrial structure in central and western regions contributes more in decreasing CO2 emissions from thermal power. Research and development (R&amp;D) investment plays a significant mediating role and thus helps to improve the level of clean electricity development and reduce carbon emissions. Finally, the policy implications are proposed to intensify R&amp;D investment, promote crossregional cooperation in sharing of clean energy, implement differentiated clean energy development policies, and establish a sustainable monitoring and evaluation system.
Dynamic simulation of landscape ecological risk in Gansu’s farming-pastoral ecotone based on topographic gradients
Authors: Yang Le , Yan Jixuan , Li Guang , Ma Weiwei , Li Tao , Gao Pengcheng , Li Qiang , Yao Xiangdong , Li Jie , Wang Wenning 
Published: January 2025

The farming-pastoral ecotone in Gansu Province, a crucial green barrier in northwestern China, faces a conflict between economic development and environmental fragility. Scientifically assessing the landscape ecological risks in this region is essential for developing an early warning system for ecological security and ensuring the sustainable management of regional ecosystems. This study systematically analyzes the dynamic evolution patterns and clustering characteristics of landscape ecological risk along the topographic gradient in the area, using Land-Use and Land-Cover Change (LUCC) data from five periods (each period representing 10 years) between 1980 and 2020, as well as Digital Elevation Model (DEM) data. Methods such as CA-Markov and the Topographic Position Index (TPI) were employed to assess these risks. Additionally, the study simulates the spatial distribution patterns of ecological risks in future years. The results reveal that from 1980 to 2020, the area of built-up land in the farming-pastoral ecotone of Gansu Province increased by approximately 82%, with roughly 21% of the expansion occurring at the expense of grasslands and 53% from arable land. Ecological risk in the study area exhibits a spatial distribution pattern characterized by lower risk in the southwest and higher risk in the northeast. Overall, ecological risk initially increased and then decreased. The area of high-risk zones has steadily decreased by approximately 50% since 2010, primarily in regions with low topographic gradients and high human activity. In other areas, high-risk levels are directly proportional to the topographic gradient, showing a high degree of spatial clustering. Consequently, land-use planning should be tailored to local conditions, and a long-term monitoring mechanism should be established. This study provides novel insights into the spatiotemporal changes in landscape ecological risk in ecologically vulnerable areas, focusing on topographic gradients.