bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of hydroxyurea on hospital stay & analgesic utilization in sickle cell anaemia with vaso-occlusive crises
Authors: Soren Uttam Kumar , Mohanty Pradeep Kumar , Meher Satyabrata , Sukla Sunil Kumar , Hiregoudar Mrutyunjay 
Published: January 2023

Background & objectives:
Hydroxyurea (HU) has been useful in preventing sickle cell vaso-occlusive crises (VOC). A few studies also suggest utility of HU, during acute VOC. Sickle cell anaemia (SCA) is of high prevalence in western districts of Odisha State, India, and VOC is a common presentation, despite being mostly of Arab-Indian haplotype. This study was undertaken to evaluate the impact of HU on hospital stay and analgesic utilization in acute painful VOC of SCA.

Methods:
Homozygous sickle cell disease (HbSS) patients were categorized as cases who were receiving low-dose HU (10 mg/kg/day) and patients who were not on HU were considered as control. Days of hospital stay, analgesic utilization and visual analogue scale (VAS) score in patients were compared with that of control. Analgesics used to control pain were tramadol hydrochloride, ketorolac and diclofenac.

Results:
A total of 359 homozygous sickle cell disease (SCD) patients with VOC were studied (187 patients and 172 controls). The patient group had lesser mean days of hospital stay (1.4 days less than controls, P<0.001) and required lesser days of analgesic utilization than controls (1.18 days less than controls, P<0.001). Significant differences were observed between patients and controls concerning VAS score and amount of tramadol hydrochloride, ketorolac and diclofenac utilization (P<0.05).

Interpretation & conclusions:
In this study, HU was found to have beneficial effects in acute VOC of homozygous SCD, which includes shortening the duration of hospital stay and reducing the net amount of analgesic utilization during hospitalization.
Endometrial serous carcinoma: A retrospective review of histological features & their clinicopathological association with disease-free survival & overall survival
Authors: Agarwal Arti , Yadav Subhash , Dusane Rohit , Menon Santosh , Rekhi Bharat , Deodhar Kedar K. 
Published: January 2023

Background & objectives:
Endometrial serous carcinoma (ESC) is a high-grade epithelial neoplasm with increased risk for metastasis and recurrence. This study was aimed to assess various histomorphological features of ESC and their clinicopathological association with disease-free survival (DFS) and overall survival (OS).

Methods:
A total of 205 slides (belonging to 120 patients) diagnosed as ESC from January 2009 to December 2015 were reviewed. Receiver operating characteristics (ROC) curves were established for the diagnostic performance of depth of invasion (DOI), tumour-free distance (TFD) to serosa and percentage myometrial invasion (MI%). OS and DFS were generated by Kaplan-Meier curves and prognostic significance by Cox regression analysis.

Results:
The mean age at diagnosis was 61.8 yr and the mean tumour size was 4.01 cm. Majority of the females were multiparous (84%; n=94) and postmenopausal (89.2%; n=107). On histopathology, <50 per cent of MI was identified in 37 of the 104 (35%), while 62/104 (59.61%) patients had ≥50 per cent MI. Seven (6.7%) patients had full-thickness invasion with serosal involvement, while five (4.8%) patients had no microscopic MI (minimal uterine serous carcinoma). Information about MI was not available in 16 patients. TFD ≥7.0 mm, DOI ≥6.0 mm and MI% ≥40 were significant variables in univariate analyses for OS; however, on multivariate analysis; none of these turned out to be an independent predictor in terms of OS. For DFS, DOI (≥6.0 mm) and MI% (≥40%) showed a significant association, in univariate as well as multivariate analysis; however, TFD (≤7.0 mm) did not show any significant association with DFS. Follow up data were available in 111 of the 120 (92.5%) patients with a five-year OS and DFS of 22.2 and 17.2 per cent, respectively.

Interpretation & conclusions:
Conventionally calculated DOI (less than or more than half thickness) did not show significance in the present study. Thus, calculating the actual myometrial DOI, MI% and TFD to serosa have the potential for contributing meaningfully to prognostication of ESC.
Serum activin-A as a predictive marker for postacne scarring
Authors: Abdel-Bary Ahmed , Tayae Eman , Magdy Basma , Hussein Tarek 
Published: January 2023

Background
Postacne scar is the most distressing sequelae of inflammatory acne vulgaris. It develops owing to abnormal wound healing process in response to inflammation. Activins are members of the family named transforming growth factors-b that are involved in inflammation, immunity, and wound healing.

Objective
To evaluate human activin-A as a predictive marker for postacne scarring and the effect of treatment with oral isotretinoin on its serum level.

Patients and methods
A total of 40 patients who presented with either moderate or severe acne vulgaris were selected for this case–control study. Patients were classified into two groups: group A had no scarring and group B had postacne scarring. Group B patients were treated with oral isotretinoin therapy. Measurement of serum activin-A levels was done using the enzyme-linked immunosorbent assay technique.

Results
The mean serum level of human activin-A was significantly higher in patients with postacne scarring (189.47±59.63 ng/ml) than patients without scarring (155.4±41.19 ng/ml). Moreover, the mean serum level of human activin-A in group B was significantly decreased after treatment with oral isotretinoin. Patients with serum human activin-A level of more than 144.8 ng/ml are more liable to develop postacne scarring with 80.0% sensitivity and 55% specificity.

Conclusion
Serum level of activin-A could be a good and reliable marker for the prediction of those patients liable to develop postacne scarring, but more in-depth studies are still required to detect the exact pathogenic action of activin-A in the development of acne scars and to test the targeting of activin-A in an attempt to prevent postacne scarring.
Portraying the Male Abuser in Contemporary Women’s Fiction
Authors: Al Thobaiti Fatmah 
Published: January 2023

Newspaper headlines show that awareness of intimate partner violence is a complicated issue that needs further examination. Works of fiction narrated by women trapped in abusive relationships are useful sites for the exploration of what intimate partner violence usually includes, and the identification of subtle behaviours that can be defined as violent and abusive but usually go unnoticed. This article submits two contemporary works of fiction, First Love and the Fifty Shades series, for a study of the covert mechanisms of emotional abuse. To understand such mechanisms, the article engages with feminist as well as postfeminist contemporary thinking on intimate partner violence. The analysis shifts the focus back to the male abuser by carefully depicting how he uses under-recognized, gendered forms of power to abuse his partner. The aim is to elucidate the capacity of first-person narratives to allow access to the abused woman’s mind, while simultaneously provoking questions about the abusers’ behaviours, making them a more powerful tool for understanding intimate partner violence than a newspaper report.
Profile and Antioxidant Capacity of Phenolic Compounds from Rice Straw
Authors: Thalia Chessa Uly , Nathania Clairine , Sukweenadhi Johan , Purwanto Maria Goretti 
Published: January 2023

ABSTRACTA study was conducted with the purpose of comparing the antioxidant properties of the aquadest extracts of three varieties of red rice straw: Memberamo, Ciherang, and Barak Cenana. The extraction was done using ultrasound-assisted extraction (UAE) technique. The compound profiling of the phenolic compounds in the extracts were done by thin-layer chromatography (TLC) and gas chromatography (GC). The antioxidant activity measurements were done using the DPPH and FRAP assays, using garlic acid as the standard. The total phenolic content assay showed no significant difference in the total phenolic content among the three rice straw varieties. TLC results showed two presumable flavonoids in Memberamo and Ciherang rice straw extracts, and three presumable flavonoids in Barak Cenana rice straw extract. GC analysis results detected three components in Memberamo rice straw extract, five components in Ciherang rice straw extract, and six components in Barak Cenana rice straw extract. The DPPH assay results showed that Barak Cenana rice straw extract indicated the highest antioxidant activity among the three varieties, while the FRAP assay results showed no significant difference in the antioxidant activity among the three rice straw varieties. Keywords: Antioxidant, phenolic compounds, rice straw, ultrasound-assisted extraction ABSTRAKPenelitian dilakukan untuk membandingkan sifat antioksidan dari ekstrak akuades jerami tiga varietas padi, yaitu padi Memberamo, padi Ciherang, dan padi Barak Cenana. Ekstraksi dilakukan dengan metode ultrasound-assisted extraction (UAE). Penelitian profil senyawa fenolik dalam ekstrak dilakukan dengan metode kromatografi lapis tipis (KLT) dan kromatografi gas (GC). Pengukuran aktivitas antioksidan dilakukan dengan uji DPPH dan uji FRAP menggunakan asam galat sebagai standar. Pengukuran kadar fenolik total menunjukkan bahwa tidak ada perbedaan signifikan antara kadar senyawa fenolik ekstrak jerami ketiga varietas padi. Hasil KLT menunjukkan dua senyawa yang diduga golongan flavonoid pada ekstrak jerami varietas Memberamo dan Ciherang, serta tiga senyawa yang diduga golongan flavonoid pada ekstrak jerami varietas Barak Cenana. Analisis GC mendeteksi tiga komponen dalam ekstrak jerami padi Memberamo, lima komponen dalam ekstrak jerami padi Ciherang, serta enam komponen dalam ekstrak jerami padi Barak Cenana. Uji DPPH menunjukkan bahwa aktivitas antioksidan tertinggi dimiliki oleh jerami padi Barak Cenana, sedangkan uji FRAP menunjukkan bahwa tidak ada perbedaan siginifikan antara aktivitas antioksidan ekstrak jerami ketiga varietas padi. Keywords: Antioksidan, senyawa fenolik, jerami padi, ultrasound-assisted extraction
STUDI KORELASI MODAL PSIKOLOGI DENGAN KESIAPAN KERJA MAHASISWA SEMESTER AKHIR DI UNIVERSITAS WIJAYA PUTRA SURABAYA
Authors: Sela Nina Permei , Grahani Firsty Oktaria , Mardiyanti Ressy 
Published: January 2023

AbstrakTantangan yang diberikan pada dunia industri semakin besar, dimana semua individu harus bisa untuk menyesuaikan diri dengan berbagai perubahan. Berbagai persiapan harus sudah dilakukan untuk bisa masuk dan bersaing di dunia industri saat ini. Salah satunya adalah kesiapan kerja yang harus dimiliki oleh seorang mahasiswa. Dalam hal ini modal psikologi memiliki peran yang penting yang turut mempengaruhi kesiapan kerja. Modal Psikologi merupakan suatu keyakinan diri, optimisme, harapan, dan kemampuan untuk bertahan menghadapi berbagai tantangan ataupun rintangan. Penelitian ini bertujuan untuk mengetahui seberapa besar hubungan antara modal psikologi dengan kesiapan kerja pada mahasiswa akhir universitas Wijaya Putra. Pengukuran modal psikologi menggunakan alat ukur yang disusun oleh Luthans dkk PCQ-24. Terdiri dari 24 item dibagi menjadi empat sub skala dengan enam item subskala dan kesiapan kerja menggunakan alat ukur dikembangkan oleh Robert P. Brady (2010) yaitu alat ukur yang berupa self-report dengan nama “Work Readiness Inventory” dengan 6 aspek yang diukur yaitu Responsibility, Flexibility, Komunikasi, Self-View, dan Health & Safety. Data yang diperoleh kemudian dianalisis dengan metode uji korelasi pearson product moment dengan bantuan SPSS 20.0 Hasil dari penelitian ini menyebutkan bahwa modal psikologi mempunyai hubungan dengan kesiapan kerja sebesar 59%.
INCREASED LEARNING OUTCOMES IN EFFECTIVE LEARNING MODELS APPLICATION ACCORDING TO THE PLOMP
Authors: Hidayat Irwin , Nur Naziha  , Atmaranie Dewi Purnama  
Published: January 2023

The study deals with a background of problems that still lack the ability of learners to receive learning because of invalid materials, impractical methods and ineffective material delivery. One way to overcome the problem is to change the learning model so that learners can receive learning well. The study aims to solve the problem of learners' learning methods and to improve the learning performance of learners with plomp study models. The study is done with a design design of learning, a plomp study model consisting of a pleminary research, phototyping phase, and enforcing phase with a valid, practical, and effective teaching device. This study is based on the development of the plomp study model with a sample of thirty students at the country's in 12 sinjai high school, which is an improvement in the study of islamic trainees, especially those being tested with islamic test analyses.
DESIGN AND BUILD OF PULSE BALANCE DEPOSIT INFORMATION SYSTEM BASED ON WEBSITE AT PT ASIA ADIJAYA PERKASA
Authors: Ulin Nuha Softi , Srirahayu Agustina , Purwanto Eko , Putri Sulistyawati Ajeng 
Published: January 2023

The credit balance deposit business is said to be still loved until now, the need for all-in-one online makes it inevitable that device users need to top up pulses, digital wallets, PLN or top up games. This makes transaction requests more and more causing many requests in the deposit process, with this problem the author wants to create a credit deposit information system.
In this study, the method used by the researcher divides it into two, namely for the first method of data collection there are observations, interviews, literature studies, and documentation. The second is the system development method using the SDLC (Systems Development Life Cycle) method, there is a needs analysis using pieces analysis, where there are system workflows, use case diagrams, activity diagrams, Sequence diagrams and the last is testing using black box techniques and beta testing.
The results of the recommendation system consist of three access rights, namely customer service, owner and member. The credit balance deposit information system can assist in the deposit process from transactions, data presentation and reporting. The results of the black box test show that all functions in the credit balance deposit information system can run as expected. The results of beta testing by filling out the questionnaire show the percentage value of the system suitability is 88.79%.
IMPLEMENTATION OF PERFORMANCE ALLOWANCE POLICY IN IMPROVING PERFORMANCE OF PEDA EMPLOYEES, MINISTRY OF RELIGION, GORONTALO REGENCY
Authors: Wahyuni Frista 
Published: January 2023

This study aims to: 1) Knowing and describing the implementation of the policy of providing Performance Allowances in improving employee performance at the Ministry of Religion of Gorontalo Regency, 2) Knowing and describing the factors that influence the implementation of the policy of providing Performance Allowances in improving employee performance at the Ministry of Religion of Gorontalo Regency.
This study uses a qualitative method. The informants of this research are employees of the Ministry of Religion of Gorontalo Regency. This research is also a type of qualitative descriptive research because this approach is more sensitive in capturing various information phenomena.
The results of the study show that: 1) The implementation of the policy of providing Performance Allowances is not in accordance with the Regulation of the Minister of Religion No. 11 of 2019 concerning the Provision of Employee Performance Allowances at the Ministry of Religion. a) the aspect of employee attendance still needs to be improved because the level of absenteeism and tardiness of employees is still too high, b) aspects of the main and functional duties still need to be reviewed because it creates social jealousy for employees who are not included in structural positions, c) aspects of the length of work still need improvements because it is not in accordance with the workload of employees, d) aspects of the quality of work produced by employees still need to be improved, because many employees do not have accuracy in their work, 2) Factors that influence the provision of Regional Performance Allowances include: work performance, expertise work and leadership
FACTORS AFFECTING INCOME INCOME IN TIRTAKABUPATEN BOALEMO REGIONAL WATER COMPANY (PDAM)
Authors: Elandri Bakari  , Imam Mashudi  , Syamsinah  
Published: January 2023

This research has a problem formulation, namely What is the level of income in the Regional Water Supply Company Tirta, Boalemo Regency. The objectives to be achieved in this study are to determine the level of income in the Regional Drinking Water Company (PDAM) of Boalemo Regency.
This research uses descriptive research with quantitative and qualitative research approaches by assigning the Head of the Public Administration and Finance Section and the Head of the Sub Division of Subscription Relations at the Regional Water Company (PDAM) of Boalemo Regency as sources of information. As well as data collection methods are observation, interview, and documentation.
The results of this study indicate that in the analysis of the factors that influence the increase in income at the local water company (PDAM) in Boalemo Regency, the income is quite significant, seen in the revenue realization and income. Customers of PDAM Tirta, Boalemo Regency The number of subscribers has a very big influence on the company's revenue as seen from the number of customers in Boalemo Serta Regency The profitability of PDAM Boalemo Regency revenue has increased quite significantly.
THE INFLUENCE OF THE WORKING CLIMATE AND MOTIVATION ON THE PERFORMANCE OF EMPLOYEES IN THE MARINE AND FISHERIES SERVICE BOALEMO COUNTY
Authors: Ratna Muhdin  , Anis Naki  , Ikram Muhammad  
Published: January 2023

The objectives of this study are: 1) to find out how much influence partially the working climate has on the performance of employees in the Boalemo District Marine and Fisheries Service; 2) to find out how much influence partially motivates the performance of employees in the Boalemo District Marine and Fisheries Service; 3) to know how much influence simultaneously the working climate and motivation on the performance of employees in the Boalemo District Marine and Fisheries Service.
The quantitative descriptive research method approach with the type of survey research that explains the causal relationship and performs hypothesis testing using a multiple regression analysis approach.
The results showed that:1) the working climate has a positive and significant effect on the performance of employees in the Boalemo District Marine and Fisheries Service with an influence contribution of 55%. This means that the higher the working climate, the higher the performance of employees in the Boalemo District Marine and Fisheries Service; 2) motivation negatively and significantly affects the performance of employees in the Boalemo District Marine and Fisheries Service with an influence contribution of 72%. This means that the higher the motivation, the lower the performance of employees in the Boalemo District Marine and Fisheries Service; 3) simultaneously the influence of the working climate and motivation will have a positive and significant effect on the performance of employees in the Marine and Fisheries Service with a 59% contribution. This means that if the working climate and motivation are applied simultaneously it will further improve the performance of its employees.
DESCRIPTION OF UREUM AND CREATININE LEVELS IN MENOPAUSE WOMEN IN THE PUSKESMAS AREA KOTA SELATAN KOTA GORONTALO
Authors: Mertosono Siti Nurkhalisah Mertosono , Yusri Halada  , Yolan Dunggio  
Published: January 2023

In menopausal women, due to decreased ovarian function, the hormone estrogen produced by the ovaries will decrease so that there is a decrease in uric acid excretion in the blood through the kidneys and result in the accumulation of uric acid in the blood. Uric acid levels in the body form crystals that accumulate and can turn into kidney stones, which will cause a person to experience impaired kidney function. One of the renal function tests is urea and creatinine.
The purpose of this study was to determine the description of urea and creatinine levels in menopausal women in the Puskesmas Kota Selatan area. This research uses descriptive quantitative research methods. The population of menopausal women was 387 people with a total sample of 20 people using a spectrophotometer.
This research was processed through the IBM SPSS Statistics V25.0 program. The results of urea examination at menopause showed that the results of high urea levels were (60.0%) and normal (40.0%) as well as the results of the creatinine examination at menopause showed that the high creatinine results were (60.0%) and the normal ones were ( 40.0%). Based on the results of the study, it can be concluded that menopause with high urea and creatinine results is more than normal. It is recommended that menopausal women need to have a healthy lifestyle.
TOTAL OF MICROBIAL CONTAMINATIONS IN RICE CHICKEN EGGS SAVE IN ROOM TEMPERATURE
Authors: Jusuf Nurseptiani , Agusriyanto Yusuf  , Al Ilham Bin Salim  
Published: January 2023

Eggs are a food that is needed by the body because of the very large nutritional content in them. The number of microbes in eggs will increase with the length of storage. The purpose of this study was to determine the total amount of microbial contamination in eggs stored at room temperature.
This research is descriptive quantitative using laboratory experimental methods. Samples were taken by purposive sampling as many as 10 eggs kept at room temperature for 1 week and 2 weeks. Data is presented in tabular form and accompanied by narration.
The results showed that 2 samples of chicken eggs that exceeded the maximum limit of microbial contamination set by SNI 3929: 2009, namely (1x105 CFU / ml), namely the TAR4 code sample for 1 week storage time of 2.
Comparison of the Implementation of Infection Prevention Before and During the Covid-19 Pandemic in Patients in the Emergency Unit of RSUD DR. M.M. Dunda Limboto
Authors: Hasan Lutvi Hairun Nissa , Naue Andy Kurniawaty , Malaha Adnan 
Published: January 2023

This study aims to determine the comparison of the implementation of infection prevention before and during the COVID-19 pandemic in Patients in the Emergency Unit of RSUD DR. M.M. DundaLimboto.
The research method used is the descriptive method with a qualitative approach by describing, analyzing, and discussing data directly sourced from informants. The informants in this study were 2 (two) IPCN people, the ER implementers consisted of the head of the ER, 1 doctor, 1 nurse, and the management, namely the head of the field of medical services.
The results of the study that have been carried out regarding the comparison of the implementation of infection prevention before and during the covid-19 pandemic in Patients in the Emergency Unit of RSUD DR. M.M. Dunda Limboto, it can be seen that there is a gap in the achievement of the PPI implementation target in the ER before and during the covid-19 pandemic, where this gap is more likely to be influenced by individual factors related to officer compliance which will affect the implementation of the PPI program, training that has not been carried out routinely both before and during the covid-19 pandemic, for management support in terms of providing PPE and handwashing facilities is still minimal, This led to an increase in the budget during the COVID-19 pandemic.