bluuebunny/crossref_metadata_2025_split huggingface dataset:
Microbiologically influenced corrosion behavior of 304 stainless steel in ZnO nanofluids
Authors: Zhang Yixuan , Gou Jinyu , Dai Yuke , Jia Jiping , Ge Honghua , Zhao Yuzeng 
Published: May 2023

Abstract
The microbiologically influenced corrosion (MIC) behavior of 304 stainless steel by sulfate-reducing bacteria (SRB) in ZnO nanofluids was studied by electrochemical measurements, antibacterial activity tests and surface analysis. The results showed that ZnO nanoparticles (NPs) had little effect on the corrosion resistance of 304 stainless steel, but could effectively inhibit the MIC of stainless steel and reduce the adhesion of biofilm on its surface, which was related to the antibacterial effect of ZnO NPs. The antibacterial effect of 100 mg/L ZnO NPs reached 89.5 %. Electrochemical tests showed that with the increase of the concentration of ZnO NPs, the passive current density of the stainless steel electrode decreased, the film resistance increased in ZnO nanofluids containing SRB, and the MIC was inhibited. The antibacterial effect of ZnO NPs is mainly due to the formation of strongly oxidising ·OH in water. The presence of ZnO NPs inhibited the formation of biofilm and deposition of sulfide on stainless steel surface, thus slowing down the corrosion damage of SRB to stainless steel.
Elevated plasma interleukin 21 is associated with higher probability and severity of idiopathic membranous nephropathy
Authors: Liu Miao , Huang Di , Liang Enyu , Deng Bishun , Huang Huijie , Zhao Zilin , Deng Li , Wang Xiaowan , Lin Haibiao , Bao Kun , Xu Peng , He Min 
Published: May 2023

Abstract

Objectives
Interleukin 21 (IL-21) is a receptor participating in innate immunity and correlates with the activation of innate immune cells. We sought to investigate the role of plasma IL-21 in patients with idiopathic membranous nephropathy (IMN).

Methods
This was a cross-sectional and case-control study. We analyzed plasma IL-21 in patients with IMN, with other kidney diseases as the diseased controls (DCs), and the healthy controls (HCs), regarding their associations with the risk of having IMN and IMN severity.

Results
We enrolled 132, 22, and 38 patients with IMN, DC, and HC, respectively. Plasma IL-21 was significantly higher in those with IMN [9.42 (6.93, 12.60)] and DC [7.84 (2.90, 7.95)] compared with HC [5.60 (2.90, 7.10)] (p<0.05). Plasma IL-21 was significantly higher in those with IMN stage III [10.36 (6.94, 20.88)] and II [9.75 (7.60, 14.27)] than those with IMN stage I [6.99 (3.91, 9.08)] (p<0.05). Plasma IL-21 was significantly higher in those with a positive anti-phospholipase A2 receptor antibody (PLA2R) [9.60 (8.27, 12.93)] than those with a negative anti-PLA2R antibody [4.84 (2.90, 11.28)] (p<0.05). Receiver operator characteristic curve analysis showed that a cutoff value of 7.665 pg/mL distinguished patients with IMN from HC and DC with a sensitivity and specificity of 68.94 and 89.47 %, respectively, and the area under the curve was 0.8184. A cutoff value of 7.830 pg/mL identified those with IMN stage II with a sensitivity and specificity of 74.03 and 89.47 %, respectively, with an area under the curve of 0.8718 (p<0.001). Multivariate regression showed that plasma IL-21 was positively correlated with anti-PLA2R and 24 h urine protein, and negatively correlated with total protein and serum albumin.

Conclusions
Plasma IL-21 levels increased significantly in patients with IMN. IL-21 may therefore serve as a biomarker for IMN.
School Library Service for Pre-Kindergarten Students: An Analysis of Certification and Standards
Authors: Cahill Maria , Adkins Denice 
Published: May 2023

Abstract
Enrollments in publicly funded pre-kindergarten (pre-K) programs are on the rise in the United States with bi-partisan support for universal pre-K increasing. Hypothetically, pre-K students should be able to access the school library and receive services and instruction from the school librarian. However, it is unclear if school librarians have either the leverage to serve these pre-K students or the necessary guidance to do so. This document analysis study involved a systematic review of school librarian certification documents, school library standards, and early childhood standards for each of the 50 states and the District of Columbia. Findings reveal uneven justification for pre-K student services and programming through school libraries. School librarians are certified to serve pre-K students in approximately half of the states, but few states have school library standards for pre-K, leaving school librarians with little direction about how best to instruct them. Implications for practice, policy, and research are discussed.
Interreligiöse Kontakte im freikirchlichen Kontext
Authors: Ehmann Matthias 
Published: May 2023

Zusammenfassung
Während Theorie und Praxis des interreligiösen Dialogs im engeren Sinne in vielen Freikirchen in Deutschland ein Randphänomen darstellen, gibt es eine reiche Tradition interreligiöser Kontakte dieser Kirchen. Der Artikel untersucht interreligiöse Dialoge am Beispiel dreier Freikirchen und zeigt Perspektiven für eine weiterführende Diskussion auf. Das Ringen um Religionsfreiheit, das christliche Zeugnis und die interreligiöse Begegnung treten dabei neben den Dialog als weitere Formen des Kontakts.
Nanocellulose: from biosources to nanofiber and their applications
Authors: Norfarhana A. S. , Ilyas R. A. , Nazrin A. , Sapuan Salit Mohd , Syafiq R. M. O. , Khoo P. S. , Nordin Abu Hassan , Omran Abdoulhdi A. Borhana , Midhun Dominic C. D. , Hawanis H. S. N. , Sari Nasmi Herlina , Mahardika Melbi , Asrofi Mochamad , Abral Hairul 
Published: May 2023

Abstract
Nanocellulose is a product of cellulose, a sustainable and plentiful resource. It’s distinctive nanoscale structure makes it a versatile, green and interesting material for a variety of applications. This article describes in detail the biosources of nanocellulose, the types and characteristics of nanocellulose, and the techniques used to produce nanocellulose fibers. The mechanical properties and morphologies of nanocellulose fibers are addressed in depth, along with their prospective applications in sectors, including paper packaging, building materials, composites, biomedicine, energy storage and filtration. In addition, the current state of nanocellulose research, including the opportunities in the field, as well as the future prospects of nanocellulose as a viable and sustainable material for a vast array of applications, are discussed.
Sugar palm (Arenga
p
innata) thermoplastic starch nanocomposite films reinforced with nanocellulose
Authors: Nazrin A. , Norfarhana A. S. , Ilyas R. A. , Sapuan S. M. , Khalina A. , Syafiq R. M. O. , Hamid M. Y. S. , Hassan C. S. , Idris I. , Khoo P. S. , Nordin A. H. , Hawanis H. S. N. , Sanyang M. L. 
Published: May 2023

Abstract
The growing consciousness about global environmental concerns, particularly landfills, in conjunction with the rapid use of petroleum-based plastics, is a key factor behind the use of natural and biodegradable polymers in short-life applications like food packaging, container, and tray. Sugar palm stem is a biomass that has proven the potential to produce biodegradable polymers such as sugar palm starch. Nevertheless, their applications were limited due to their low tensile strength and excessive hydrophilicity. Plasticization using polyols, reinforcement with sugar palm fiber, cellulose, microcrystalline cellulose, or nanocellulose, blending with thermoplastic polymer, and addition of essential oils has been used to maximize the functional qualities of the starch biopolymer. As the content of plasticizers grew, the glass transition temperature and water absorption ability decreased. Furthermore, the addition of sugar palm nanocellulose to sugar palm starch improves the performances of sugar palm starch-based films as a packaging material. Addition of essential oil contributes to antibacterial properties and slightly improved tensile strength of the film. A comprehensive understanding on the interaction of starch-based biodegradable polymer and nanocellulose constituents for enhancing the physico-chemical properties of starch-based films is prerequisite for researchers in the design of industrial products with enhanced functional attributes. To address the knowledge gap, more studies including the reinforcement of new types of biodegradable polymer and nanocellulose derived from natural sources should be conducted in order to continually populate the database for research purposes.
Toward a New Science of the Clinical Uses of the Arts
Authors: Brown Steven , Cameirao Jacob 
Published: May 2023

Abstract
The arts are used clinically in a wide variety of applications, spanning from physical therapy to psychotherapy. We present a theoretical analysis of these clinical applications that is grounded in a unified model of the arts. Such an approach is based on an understanding of the relationships among the various art forms and how the arts are able to impact non-art functions via transfer effects. A unified model helps to clarify the distinction between near and far transfer in the clinical uses of the arts. The empirical evidence suggests that art applications for physical therapy tend to be based on near-transfer effects and show high specificity for the employed art forms. By contrast, art applications for psychotherapy tend to be based on far transfer and show less specificity for the employed art forms. We argue that a theory of the clinical uses of the arts has to be predicated on a unified model of the arts themselves. Such a model provides a rational basis for understanding how art forms are able to bring about their clinical effects.
Subregional Differences in Medium Spiny Neuron Intrinsic Excitability Properties between Nucleus Accumbens Core and Shell in Male Rats
Authors: Maria-Rios Cristina E. , Murphy Geoffrey G. , Morrow Jonathan D. 
Published: May 2023

AbstractThe nucleus accumbens (NAc) is known for its central role in reward and motivation (Day and Carelli, 2007; Floresco, 2015; Salgado and Kaplitt, 2015). Decades of research on the cellular arrangement, density, and connectivity of the NAc have identified two main subregions known as the core and shell (Záborszky et al., 1985; Berendse and Groenewegen, 1990; Zahm and Heimer, 1990). Although anatomically and functionally different, both the NAc core and shell are mainly comprised of GABAergic projection neurons known as medium spiny neurons (MSNs) (Matamales et al., 2009). Several studies have identified key morphologic differences between core and shell MSNs (Meredith et al., 1992; Forlano and Woolley, 2010) but few studies have directly addressed how core and shell MSNs differ in their intrinsic excitability (Pennartz et al., 1992; O’Donnell and Grace, 1993). Using whole-cell patch-clamp recordings in slices prepared from naive and rewarded male rats, we found that MSNs in the NAc shell were significantly more excitable than MSNs in the NAc core in both groups. In the shell, MSNs had significantly greater input resistance, lower cell capacitance, and a greater sag. This was accompanied by a lower action potential current threshold, a greater number of action potentials, and faster firing frequency compared with core MSNs. These subregional differences in intrinsic excitability could provide a potential physiological link to the distinct anatomic characteristics of core and shell MSNs and to their distinct functional roles in reward learning (Zahm, 1999; Ito and Hayen, 2011; Saddoris et al., 2015; West and Carelli, 2016).
Behavioral and Transcriptome Profiling of Heterozygous Rab10 Knock-Out Mice
Authors: Bunner Wyatt , Wang Jie , Cohen Sarah , Bashtovyy Denys , Perry Rachel , Shookster Daniel , Landry Taylor , Harris Elizabeth M. , Stackman Robert , Tran Tuan D. , Yasuda Ryohei , Szatmari Erzsebet M. 
Published: May 2023

AbstractA central question in the field of aging research is to identify the cellular and molecular basis of neuroresilience. One potential candidate is the small GTPase, Rab10. Here, we used Rab10+/−mice to investigate the molecular mechanisms underlying Rab10-mediated neuroresilience. Brain expression analysis of 880 genes involved in neurodegeneration showed that Rab10+/−mice have increased activation of pathways associated with neuronal metabolism, structural integrity, neurotransmission, and neuroplasticity compared with their Rab10+/+littermates. Lower activation was observed for pathways involved in neuroinflammation and aging. We identified and validated several differentially expressed genes (DEGs), including Stx2, Stx1b, Vegfa, and Lrrc25 (downregulated) and Prkaa2, Syt4, and Grin2d (upregulated). Behavioral testing showed that Rab10+/−mice perform better in a hippocampal-dependent spatial task (object in place test), while their performance in a classical conditioning task (trace eyeblink classical conditioning, TECC) was significantly impaired. Therefore, our findings indicate that Rab10 differentially controls the brain circuitry of hippocampal-dependent spatial memory and higher-order behavior that requires intact cortex-hippocampal circuitry. Transcriptome and biochemical characterization of these mice suggest that glutamate ionotropic receptor NMDA type subunit 2D (GRIN2D or GluN2D) is affected by Rab10 signaling. Further work is needed to evaluate whether GRIN2D mediates the behavioral phenotypes of the Rab10+/−mice. We conclude that Rab10+/−mice described here can be a valuable tool to study the mechanisms of resilience in Alzheimer’s disease (AD) model mice and to identify novel therapeutical targets to prevent cognitive decline associated with normal and pathologic aging.
Noncoding SNP at rs1663689 represses ADGRG6 via interchromosomal interaction and reduces lung cancer progression
Authors: Lei Xinyue , Tian Xiaoling , Wang Hao , Xu Xinran , Li Guoli , Liu Wenxu , Wang Dan , Xiao Zengtuan , Zhang Mengzhe , Li Mulin Jun , Zhang Zhenfa , Ma Zhenyi , Liu Zhe 
Published: May 2023

AbstractA previous genome‐wide association study (GWAS) revealed an association of the noncoding SNP rs1663689 with susceptibility to lung cancer in the Chinese population. However, the underlying mechanism is unknown. In this study, using allele‐specific 4C‐seq in heterozygous lung cancer cells combined with epigenetic information from CRISPR/Cas9‐edited cell lines, we show that the rs1663689 C/C variant represses the expression of ADGRG6, a gene located on a separate chromosome, through an interchromosomal interaction of the rs1663689 bearing region with the ADGRG6 promoter. This reduces downstream cAMP‐PKA signaling and subsequently tumor growth both in vitro and in xenograft models. Using patient‐derived organoids, we show that rs1663689 T/T—but not C/C—bearing lung tumors are sensitive to the PKA inhibitor H89, potentially informing therapeutic strategies. Our study identifies a genetic variant‐mediated interchromosomal interaction underlying ADGRG6 regulation and suggests that targeting the cAMP‐PKA signaling pathway may be beneficial in lung cancer patients bearing the homozygous risk genotype at rs1663689.
Potentiation of neuronal activity by tonic GluD1 current in brain slices
Authors: Copeland Daniel S , Gugel Aleigha , Gantz Stephanie C 
Published: May 2023

AbstractIon channel function of native delta glutamate receptors (GluDR) is incompletely understood. Previously, we and others have shown that activation of Gαq protein‐coupled receptors (GqPCR) produces a slow inward current carried by GluD1R. GluD1R also carries a tonic cation current of unknown cause. Here, using voltage‐clamp electrophysiological recordings from adult mouse brain slices containing the dorsal raphe nucleus, we find no role of ongoing G‐protein‐coupled receptor activity in generating or sustaining tonic GluD1R currents. Neither augmentation nor disruption of G protein activity affects tonic GluD1R currents, suggesting that ongoing G‐protein‐coupled receptor activity does not give rise to tonic GluD1R currents. Further, the tonic GluD1R current is unaffected by the addition of external glycine or D‐serine, which influences GluD2R current at millimolar concentrations. Instead, GqPCR‐stimulated and tonic GluD1R currents are regulated by physiological levels of external calcium. In current‐clamp recordings, block of GluD1R channels hyperpolarizes the membrane by ~7 mV at subthreshold potentials, reducing excitability. Thus, GluD1R carries a G‐protein‐independent tonic current that contributes to subthreshold neuronal excitation in the dorsal raphe nucleus.
Predicting cellular responses to complex perturbations in high‐throughput screens
Authors: Lotfollahi Mohammad , Klimovskaia Susmelj Anna , De Donno Carlo , Hetzel Leon , Ji Yuge , Ibarra Ignacio L , Srivatsan Sanjay R , Naghipourfar Mohsen , Daza Riza M , Martin Beth , Shendure Jay , McFaline‐Figueroa Jose L , Boyeau Pierre , Wolf F Alexander , Yakubova Nafissa , Günnemann Stephan , Trapnell Cole , Lopez‐Paz David , Theis Fabian J 
Published: May 2023

AbstractRecent advances in multiplexed single‐cell transcriptomics experiments facilitate the high‐throughput study of drug and genetic perturbations. However, an exhaustive exploration of the combinatorial perturbation space is experimentally unfeasible. Therefore, computational methods are needed to predict, interpret, and prioritize perturbations. Here, we present the compositional perturbation autoencoder (CPA), which combines the interpretability of linear models with the flexibility of deep‐learning approaches for single‐cell response modeling. CPA learns to in silico predict transcriptional perturbation response at the single‐cell level for unseen dosages, cell types, time points, and species. Using newly generated single‐cell drug combination data, we validate that CPA can predict unseen drug combinations while outperforming baseline models. Additionally, the architecture's modularity enables incorporating the chemical representation of the drugs, allowing the prediction of cellular response to completely unseen drugs. Furthermore, CPA is also applicable to genetic combinatorial screens. We demonstrate this by imputing in silico 5,329 missing combinations (97.6% of all possibilities) in a single‐cell Perturb‐seq experiment with diverse genetic interactions. We envision CPA will facilitate efficient experimental design and hypothesis generation by enabling in silico response prediction at the single‐cell level and thus accelerate therapeutic applications using single‐cell technologies.
Keanekaragaman Jamur Makro dan Potensinya di Kampung Citlahab, Balai Taman Nasional Gunung Halimun Salak
Authors: Fikri Ahmad Habib Nur , Rosyid Caroline Humaira Rifalina , Mahajarifar Ratna Zahara , Fadlun Fia , Noverita Noverita 
Published: May 2023

AbstrakKampung Citalahab termasuk dalam Kawasan Pusat Penelitian Cikaniki yang terletak di wilayah TNGHS dengan kekayaan keanekaragaman hayati yang cukup tinggi, salah satunya jamur makro. Penelitian dilakukan dengan tujuan untuk mendapatkan data keanekaragaman jenis jamur makro di Kampung Citalahab, Kawasan Pusat Penelitian Cikaniki, TNGHS serta untuk mengetahui potensinya. Metode yang digunakan dalam penelitian adalah metode searching per plot di tiga jalur yaitu jalur aliran sungai, jalur hutan, dan jalur pekarangan desa serta dilanjutkan dengan pengambilan sampel gambar menggunakan kamera, pengukuran faktor lingkungan, dan identifikasi sampel. Jamur yang ditemukan sebanyak 614 individu dari 43 jenis yang berbeda. Tingkat keanekaragaman jenis di tiga jalur tergolong rendah sampai sedang, dengan indeks kesamaan tertinggi yaitu 37,21%. Jamur makro yang sering ditemui adalah Microporus xanthopus, Microporus affinis, Xylaria longipes, dan Auricularia auricula. Beberapa genus jamur seperti Auricularia dan Schizophyllum yang ditemukan di Kampung Citalahab berpotensi sebagai bahan pangan. Sedangkan genus jamur Ganoderma, Xylaria, Microporus, Daldinea, dan Trametes berpotensi sebagai bahan obat-obatan. Masyarakat di Kampung Citalahab belum sepenuhnya memanfaatkan jamur yang tersedia di sana akibat minimnya informasi yang didapatkan oleh masyarakat setempat. AbstractCitalahab's village is one of the Cikaniki Research Station Centers located in the TNGHS area with a considerable wealth of biodiversity, one of which is the macro fungi. Research are conducted with the aim of obtaining data for diversity in the macro types of fungi in the village of Citalahab, the Cikaniki Research Station Center, TNGHS and to discover their potential. The method used in research is the searching per plot on 3 locations of streams, forest trails, and rural garden paths and followed by camera sampling, measuring environmental factors, and sample identification. The fungi found as many as 614 individuals from 43 different kinds. The level of variability in all three pathways is low to moderate, with the highest similarity index being 37,21%. The oft identified macro fungus is Microporus xanthopus, Microporus affinis, Xxylaria longipes, and Auricularia auricula. Some genus of fungi such as Auricularia and Schzophyllum found in the Citalahab village are potential food. While the genus fungi of Ganoderma, Xylaria, Microporus, Daldinea, and Trametes are potentially pharmaceuticals. The people of the Citalahab village have not fully benefited from the local people's lack of information available there.
O aggiornamento da teologia matrimonial na Exortação Amoris Laetitia
Authors: Emerim Velho Jonas 
Published: May 2023

A família e o matrimônio sempre foram preocupações para a Igreja. Diante da crise hodierna em que vive o matrimônio, busca-se responder como a teologia pode ajudar os casais cristãos a viverem a alegria do amor. Na doutrina matrimonial católica foi predominante a ênfase na procriação, mas, a partir do Concílio Vaticano II, a finalidade unitiva do matrimônio também foi valorizada. A Exortação pós-Sinodal Amoris Laetitia encontra-se em continuidade com a perspectiva do Vaticano II. Assim, neste trabalho, busca-se primeiro estudar o desenvolvimento da teologia matrimonial e o acento dado na procriação; depois, analisa-se a teologia do matrimônio presente na Amoris Laetitia, para, por fim, à luz do documento, indicar caminhos para os cônjuges católicos descobrirem e viverem na alegria do amor.
Identificación de potenciales afectaciones por instalaciones turísticas en drenajes de la cuenca hidrográfica del Rio Cuale-Pitillal (zona costera de Puerto Vallarta, México)
Authors: Ibarra-Núñez Edgar , Torres Rodríguez Alicia 
Published: May 2023

Este trabajo tiene como objetivo identificar potenciales afectaciones sobre los drenajes naturales, tomando como ejemplo la desembocadura de la cuenca hidrográfica Rio Cuale-Pitillal en Puerto Vallarta, México.
Para esto se realizó la superposición de las obras turísticas sobre secciones de las corrientes naturales utilizando un Sistema de Información Geográfica (SIG), un Modelo Digital de Elevación y la revisión de publicaciones de la interacción antropogénica con cuencas hidrográficas.
Debido a la interrupción de drenajes naturales, se ha dado un cambio de la configuración espacial y paisajística de la cuenca, además, se infiere que en el área de estudio pueden estarse suscitando efectos negativos relacionados a descargas de aguas residuales y déficit sedimentario.
La identificación espacial de estos efectos, puede contribuir a la planificación costera para localizar puntos críticos de afectación a la integridad funcional de la cuenca y potenciales espacios de riesgos a la población en caso de huracanes o tormentas.