bluuebunny/crossref_metadata_2025_split huggingface dataset:
Need for Standardized Measure of Modern Method Availability: Assessment of Indicators Using Health Facility Data from Three Country Contexts
Authors: Barden‐O'Fallon Janine , Ijdi Rashida‐E 
Published: January 2023

AbstractThe concept of contraceptive method choice is complex and difficult to measure, usually requiring multiple metrics that represent the service environment, access, and acceptability. One of the most used measures for the family planning service delivery environment is method availability, or specifically, the contraceptive options that are available to clients at any given family planning service delivery point. Despite the importance of the measure, indicator definitions vary widely and are not standardized. We identified six versions of the method availability indicator and calculated each version using Service Provision Assessment data from three countries with varying family planning profiles, health service structures, and from different geographic areas: Bangladesh, the Democratic Republic of Congo, and Haiti. We compared method availability estimates by urban/rural location, facility type, and across country context. Our results showed a wide variability in method availability estimates depending on the indicator used. Generally, indicators requiring a particular mix of method types had lower estimates of method availability than indicators only requiring a minimum number of methods. Results are discussed and recommendations are made to standardize indicator language and guidance. We further recommend the standardization of an indicator with a minimum mix of method types to ensure that a variety of method preferences can be met.
Morphology and volume of Meibomian glands ex vivo pre and post partial tarsal plate excision, cryotherapy and laser therapy in the dog using microCT
Authors: Zwiauer‐Wolfbeisser Victoria , Handschuh Stephan , Tichy Alexander , Nell Barbara 
Published: January 2023

AbstractObjectiveTo determine the morphology and volume of Meibomian glands (MG) of dogs with microCT before and after partial tarsal plate excision (PTPE), cryotherapy, and laser therapy.ProcedureMicroCT scans were made of 12 upper lids (ULs) and lower lids (LLs) of 12 dogs. After undergoing PTPE, 10 ULs and LLs were scanned again, and one UL and one LL was scanned after laser therapy and one UL and one LL after cryotherapy.ResultsThe length of the area containing MGs did not change pre‐ and post‐PTPE, and cryo‐ or laser therapy. The mean number of MGs in the ULs and LLs was 30.50 and 29.42, respectively, and did not change during the procedures. The average length of one individual MG was 2.60 mm. The mean volume of MGs in the 10 ULs and LLs pre‐PTPE was 21.45 and 17.2 mm3, respectively, and 12.84 and 11.25 mm3 in the UL and LL after PTPE, respectively. The mean volume of MGs decreased from 29.78 mm3 precryotherapy to 28.91 mm3 post‐treatment and in the lower eyelid from 22.87 to 22.4 mm3 after cryotherapy. The mean volume of MGs in the UL and LL before laser therapy was 8.95 and 6.78 mm3, respectively, and after 9.25 and 6.38 mm3, respectively.ConclusionMicroCT is a valuable tool to determine the morphology and the volume of MGs and to demonstrate changes that occur after PTPE, laser‐, and cryotherapy. There is no need for additional preparation, such as staining, of the specimen prior to scanning.
Effects of a 12-week, seated, virtual, home-based tele-exercise programme compared with a prerecorded video-based exercise programme in people with chronic neurological impairments: protocol for a randomised controlled trial
Authors: Divecha Ayushi A , Bialek Amy , Kumar Devina S , Garn Rachel M , Currie Lydia E J , Campos Talita , Friel Kathleen M 
Published: January 2023

IntroductionExercise is vital to staying well and preventing secondary complications in people with chronic neurological impairments (CNI). Appropriate exercise is often inaccessible to this population. The purpose of the study is to investigate the effects of a seated, virtual exercise programme on heart rate, recovery, fatigue, pain, motivation, enjoyment and quality of life in people with CNI.Methods and analysisIndividuals with CNI will be screened for eligibility, and 60 participants will be randomised 1:1 into either a live or prerecorded group. There is no geographical limitation to where participants reside, since participation is virtual. The study will be coordinated by one site in White Plains, New York, USA. The live group will exercise with an instructor via Zoom while the prerecorded group will exercise at their chosen time using prerecorded videos, 3×/week for 12 weeks. Primary outcome measures: change in heart rate during exercise/recovery. Secondary outcome measures: fatigue, motivation, level of pain and exertion, physical well-being, enjoyment of physical activity, motivation and quality of life. Outcomes will be assessed at baseline, midpoint, end of study and 1-month poststudy. Adverse events, medication changes and physical activity will be tracked throughout. Within-group and between-group comparisons will be performed by using analysis of covariance and regression.Ethics and disseminationBRANY IRB approval: 22 September 2020, protocol #20-08-388-512. All participants will provide written informed consent. Results will be disseminated through presentations, publications and ClinicalTrials.gov.Trial registration numberNCT04564495.
Promoting adherence to stroke secondary prevention behaviours by imparting behaviour change skills: protocol for a single-arm pilot trial of Living Well After Stroke
Authors: Smith Stephanie , Parkinson Joy , Caitens Thomas , Sanders Andrea , Murphy Lisa , Hamilton Kyra 
Published: January 2023

IntroductionSurvivors of stroke have an elevated risk of recurrent stroke. Prompt intervention to support healthy lifestyle modification following an initial stroke is crucial for effective secondary prevention of stroke. However, many patients do not receive adequate postdischarge support for secondary prevention, particularly if not referred to inpatient rehabilitation. Living Well After Stroke is a health promotion programme based on the health action process approach (HAPA), which is designed to support this underserviced group to improve and self-manage secondary prevention behavioural performance (eg, diet, exercise, medication-adherence) by equipping participants with a toolkit of theory-based and evidence-based behaviour change strategies and techniques that are transferable to different behavioural contexts.Methods and analysisThe target sample is 118 adults living in Queensland, Australia, with stroke or transient ischaemic attack not referred to inpatient rehabilitation. Adopting a prospective single-arm trial design, the intervention comprises five behaviour change sessions over an 8-week period. Participants will receive a mix of individual-based and group-based assessments and interventions, based on the HAPA theoretical framework, delivered via telehealth or in-person (eg, public library). Measures of primary (ie, goal behaviours 1 and 2) and secondary outcomes (intention, outcome expectancy, risk perception, self-efficacy, planning, action control, subjective well-being) will be taken at 2 weeks, 4 weeks, 8 weeks and 16 weeks. The primary outcomes of the trial will be behavioural performance and transferability of behaviour change skills at 16 weeks.Ethics and disseminationThe study has received ethical approval from the Griffith University Human Research Ethics Committee (Ref no: 2022/308). Informed consent is obtained via telephone prior to data collection. Findings will be presented in the form of peer-reviewed journal articles, industry reports and conference presentations, and will be used to inform the continued development and refinement of the programme for testing in a future fully powered trial.
Risk factors for hamstring muscle injury in male elite football: medical expert experience and conclusions from 15 European Champions League clubs
Authors: Ekstrand Jan , Ueblacker Peter , Van Zoest Wart , Verheijen Raymond , Vanhecke Bruno , van Wijk Maikel , Bengtsson Håkan 
Published: January 2023

ObjectivesTo describe the perceived importance of suggested hamstring injury risk factors according to chief medical officers (CMOs) of European male professional football clubs. A secondary objective was to compare if these perceptions differed between teams with a lower-than-average hamstring injury burden and teams with a higher than average hamstring injury burden.MethodsFirst, CMOs of 15 European professional male football clubs were asked to suggest risk factors for hamstring injury in their club. The perceived importance of the suggested risk factors was then rated by all participants on a 5-graded Likert scale. Participating teams were divided in two groups depending on their hamstring injury burden during the 2019/2020 and 2020/2021 seasons. The LOW group consisted of seven teams that had a lower than average hamstring injury burden. The HIGH group consisted of eight teams that had a higher-than-average hamstring injury burden.ResultsTwenty-one risk factors were suggested. The majority were extrinsic in nature, associated with coaching staff, team or club rather than players themselves. ‘Lack of communication between medical staff and coaching staff’ had the highest average importance (weighted average=3.7) followed by ‘Lack of regular exposure to high-speed football during training sessions’ (weighted average=3.6). The HIGH group perceived the player factors fatigue and wellness as more important than the LOW group.ConclusionAccording to CMOs recruited in this study, most risk factors for hamstring injuries are extrinsic and associated with the club and coaching staff, and not the players themselves.
Gender disparities in industry compensation and research payments among neurointerventional surgeons in the USA
Authors: Kyarunts Mariam , Michaelcheck Charlotte E , Kobeissi Hassan , Kallmes David F , Agid Ronit , Brinjikji Waleed 
Published: January 2023

BackgroundThe purpose of this study is to examine the presence of gender disparity represented by industry payments and research funding within the field of interventional neuroradiology.MethodsPayment information was collected using the Centers for Medicare and Medicaid Services Open Payment database for the year 2019. Kruskal-Wallis tests were used to analyze differences in annual compensation based on sex in $US, while controlling for geographic factors, academic rank, and h-index. A sample t-test was performed to look at gender differences in h-indexes.ResultsThe study cohort was comprised of 893 interventional neuroradiologists, 73 (8.2%) of which were female. Of the $48889.20 in mean annual payments reported in the database, $5847.13 (11.2%) went to female interventional neuroradiologists (P<0.05). The significant difference in compensation between male and female neuroradiologists was evident after controlling for state-level variance and academic position. There was a statistically significant difference in total reimbursement (P<0.001), research (P<0.001), consulting (P<0.04), food and beverage (P<0.02), and compensation for services other than consulting between males and females (P<0.02). A statistically significant difference was found for h-index based on gender (males=16.7, females=10.1; P<0.001).ConclusionsOur findings indicate that in the field of interventional neuroradiology, females receive less research funding and private industry compensation, have lower h-indexes, and are less likely to occupy the highest academic positions. The difference in funding did not differ when accounting for geographic state of practice and academic rank. Future studies should work to identify potential contributory factors of these trends.
Isotropic compact stars in four-dimensional Einstein–Gauss–Bonnet gravity coupled with scalar field: reconstruction of model
Authors: Nashed G. G. L. , Nojiri Shin’ichi 
Published: January 2023

AbstractIt has been suggested that the Einstein–Gauss–Bonnet theory coupled with a scalar field (EGBS) may allow us to obtain physically viable models of celestial phenomena such that the scalar field effect is active in standard four dimensions. We consider the spherically symmetric and static configuration of the compact star and explain the consequences of the EGBS theory in the frame of stellar modeling. In our formulation, for any given static profile of energy density $$\rho $$
ρ
with spherical symmetry and the arbitrary equation of state (EoS) of matter, we can construct a model which reproduces the profile. Because the profile of the energy density determines the mass M and the radius $$R_s$$

R
s

of the compact star, an arbitrary relation between the mass M and the radius $$R_s$$

R
s

of the compact star can be realized by adjusting the potential and the coefficient function of the Gauss–Bonnet term in the action of EGBS theory. This could be regarded as a degeneracy between the EoS and the functions characterizing the model, which indicates that the mass–radius relation alone is insufficient to constrain the model. Here, we investigate a novel class of analytic spherically symmetric interior solutions by the polytropic EoS. We discuss our model in detail and show that it is in agreement with the necessary physical conditions required for any realistic compact star, confirming that EGBS theory is consistent with observations.
Zinc Finger MYND-Type Containing 8 (ZMYND8) Is Epigenetically Regulated in Mutant Isocitrate Dehydrogenase 1 (IDH1) Glioma to Promote Radioresistance
Authors: Carney Stephen V. , Banerjee Kaushik , Mujeeb Anzar , Zhu Brandon , Haase Santiago , Varela Maria L. , Kadiyala Padma , Tronrud Claire E. , Zhu Ziwen , Mukherji Devarshi , Gorla Preethi , Sun Yilun , Tagett Rebecca , Núñez Felipe J. , Luo Maowu , Luo Weibo , Ljungman Mats , Liu Yayuan , Xia Ziyun , Schwendeman Anna , Qin Tingting , Sartor Maureen A. , Costello Joseph F. , Cahill Daniel P. , Lowenstein Pedro R. , Castro Maria G. 
Published: January 2023

Abstract

Purpose:
Mutant isocitrate dehydrogenase 1 (mIDH1) alters the epigenetic regulation of chromatin, leading to a hypermethylation phenotype in adult glioma. This work focuses on identifying gene targets epigenetically dysregulated by mIDH1 to confer therapeutic resistance to ionizing radiation (IR).

Experimental Design:
We evaluated changes in the transcriptome and epigenome in a radioresistant mIDH1 patient-derived glioma cell culture (GCC) following treatment with an mIDH1-specific inhibitor, AGI-5198. We identified Zinc Finger MYND-Type Containing 8 (ZMYND8) as a potential target of mIDH1 reprogramming. We suppressed ZMYND8 expression by shRNA knockdown and genetic knockout (KO) in mIDH1 glioma cells and then assessed cellular viability to IR. We assessed the sensitivity of mIDH1 GCCS to pharmacologic inhibition of ZMYND8-interacting partners: HDAC, BRD4, and PARP.

Results:
Inhibition of mIDH1 leads to an upregulation of gene networks involved in replication stress. We found that the expression of ZMYND8, a regulator of DNA damage response, was decreased in three patient-derived mIDH1 GCCs after treatment with AGI-5198. Knockdown of ZMYND8 expression sensitized mIDH1 GCCs to radiotherapy marked by decreased cellular viability. Following IR, mIDH1 glioma cells with ZMYND8 KO exhibit significant phosphorylation of ATM and sustained γH2AX activation. ZMYND8 KO mIDH1 GCCs were further responsive to IR when treated with either BRD4 or HDAC inhibitors. PARP inhibition further enhanced the efficacy of radiotherapy in ZMYND8 KO mIDH1 glioma cells.

Conclusions:
These findings indicate the impact of ZMYND8 in the maintenance of genomic integrity and repair of IR-induced DNA damage in mIDH1 glioma.
See related commentary by Sachdev et al., p. 1648
Allogeneic CAR T Cells Targeting DLL3 Are Efficacious and Safe in Preclinical Models of Small Cell Lung Cancer
Authors: Zhang Yi , Tacheva-Grigorova Silvia K. , Sutton Janette , Melton Zea , Mak Yvonne S.L. , Lay Cecilia , Smith Bryan A. , Sai Tao , Van Blarcom Thomas , Sasu Barbra J. , Panowski Siler H. 
Published: January 2023

AbstractPurpose:Small cell lung cancer (SCLC) is an aggressive disease with limited treatment options. Delta-like ligand 3 (DLL3) is highly expressed on SCLC and several other types of neuroendocrine cancers, with limited normal tissue RNA expression in brain, pituitary, and testis, making it a promising CAR T-cell target for SCLC and other solid tumor indications.Experimental Design:A large panel of anti-DLL3 scFv-based CARs were characterized for both in vitro and in vivo activity. To understand the potential for pituitary and brain toxicity, subcutaneous or intracranial tumors expressing DLL3 were implanted in mice and treated with mouse cross-reactive DLL3 CAR T cells.Results:A subset of CARs demonstrated high sensitivity for targets with low DLL3 density and long-term killing potential in vitro. Infusion of DLL3 CAR T cells led to robust antitumor efficacy, including complete responses, in subcutaneous and systemic SCLC in vivo models. CAR T-cell infiltration into intermediate and posterior pituitary was detected, but no tissue damage in brain or pituitary was observed, and the hormone-secretion function of the pituitary was not ablated.Conclusions:In summary, the preclinical efficacy and safety data presented here support further evaluation of DLL3 CAR T cells as potential clinical candidates for the treatment of SCLC.
Much Ado about ASPS: The Rapidly Changing Treatment Paradigms of 2022
Authors: Wilky Breelyn A. , Maleddu Alessandra 
Published: January 2023

SummaryA recent randomized phase II study of sunitinib or cediranib in alveolar soft part sarcoma established benchmark activity for commonly used tyrosine kinase inhibitors (TKI). The impact of TKIs, as well as immunotherapy, has redefined treatment paradigms and greatly improved outcomes for this historically dismal sarcoma.See related article by Nguyen et al., p. 1200
Record of a dense succession of drowning phases in the Alpstein mountains, northeastern Switzerland: Part II—the Lower Cretaceous Schrattenkalk Formation (late Barremian)
Authors: Pictet Antoine , Tschanz Karl , Kürsteiner Peter 
Published: January 2023

AbstractThe Schrattenkalk Formation represents a complete succession of Lower Cretaceous shallow-water carbonate platform series cropping out in the Alpstein massif of north-eastern Switzerland. The Schrattenkalk Formation is traditionally divided into two sedimentary units, the “Lower” and the “Upper” Schrattenkalk, separated by the more marly Rawil Member. The “Lower” Schrattenkalk is habitually dated to the late Barremian, while the Rawil Member and the “Upper” Schrattenkalk are dated to the early Aptian. New field observations, however, call the lithostratigraphic dichotomy of the Schrattenkalk into question, as the neritic carbonates are disrupted by several key surfaces associated with karstic episodes and/or transgressive sediments, corresponding to ammonite-rich hemipelagic deposits on the distal shelf. A large number of ammonites were collected in the Drusberg Member as well as rare ammonites from the Schrattenkalk Formation. These ammonites as well as the neritic macrofauna from the Schrattenkalk Formation allow a precise dating of the onset of the Schrattenkalk Formation across the Alpstein massif and its successive phases of progradation. Three successive carbonate bodies and a fourth sedimentary intermediate rock body at the top of the Schrattenkalk platform are defined, based on new biostratigraphic data and updated interpretations of the sequence stratigraphy and geochemical data. The data shows a progressive onset of the Schrattenkalk carbonate platform along the studied transect, following a SE progradation over time. The oldest deposits refer to the upper Barremian T. vandenheckii Zone and the youngest carbonates to the uppermost Barremian M. sarasini Subzone. The new dating of the discontinuity surfaces and key-beds highlight three successive flooding events. The first drowning phase, which correlates with the "Sartousiana" event, dates from the middle late Barremian (upper T. vandenheckii—lower G. sartousiana Zone). The second phase, represented by the Rawil Member, is an incipient drowning, which seems to coincide with the latest Barremian Taxy event (usually reported to the I. giraudi and lowermost M. sarasini zones) according to rare ammonite discoveries. The final demise of the Schrattenkalk platform, situated close to the Barremian-Aptian boundary, is related to an exposure and consecutive drowning event.
Assessment of the influence of selected stress factors on the growth and survival of Listeria monocytogenes
Authors: Wiktorczyk-Kapischke Natalia , Skowron Krzysztof , Wałecka-Zacharska Ewa , Grudlewska-Buda Katarzyna , Wnuk Kacper , Buszko Katarzyna , Gospodarek-Komkowska Eugenia 
Published: January 2023

AbstractBackgroundListeria monocytogenesare Gram-positive rods, which are the etiological factor oflisteriosis.L. monocytogenesquickly adapts to changing environmental conditions. Since the main source of rods is food, its elimination from the production line is a priority. The study aimed to evaluate the influence of selected stress factors on the growth and survival ofL. monocytogenesstrains isolated from food products and clinical material.ResultsWe distinguished fifty genetically different strains ofL. monocytogenes(PFGE method). Sixty-two percent of the tested strains represented 1/2a-3a serogroup. Sixty percent of the rods possessed ten examined virulence genes (fbpA,plcA,hlyA,plcB,inlB,actA,iap,inlA,mpl, prfA). Listeria Pathogenicity Island 1 (LIPI-1) was demonstrated among 38 (76.0%) strains. Majority (92.0%) of strains (46) were sensitive to all examined antibiotics. The most effective concentration of bacteriophage (inhibiting the growth of 22 strains; 44.0%) was 5 × 108PFU. In turn, the concentration of 8% of NaCl was enough to inhibit the growth of 31 strains (62.0%). The clinical strain tolerated the broadest pH range (3 to 10). Five strains survived the 60-min exposure to 70˚C, whereas all were alive at each time stage of the cold stress experiment. During the stress of cyclic freezing-defrosting, an increase in the number of bacteria was shown after the first cycle, and a decrease was only observed after cycle 3. The least sensitive to low nutrients content were strains isolated from frozen food. The high BHI concentration promoted the growth of all groups.ConclusionsData on survival in stress conditions can form the basis for one of the hypotheses explaining the formation of persistent strains. Such studies are also helpful for planning appropriate hygiene strategies within the food industry.