bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mogamulizumab-Associated Myositis With and Without Myasthenia Gravis and/or Myocarditis in Patients With T-Cell Lymphoma
Authors: Virgen Cesar A , Sparks Jeffrey A , Nohria Anju , O’Hare Meabh J , Goyal Amrita , Said Jordan T , Tawa Marianne , LeBoeuf Nicole R , Kupper Thomas S , Fisher David C , Larocca Cecilia 
Published: June 2023

Abstract
Mogamulizumab is being increasingly prescribed for the treatment of T-cell lymphomas (MF/SS/ATLL). We conducted a retrospective cohort study to identify muscular immune-related adverse events (irAEs) associated with mogamulizumab in patients with T-cell lymphoma followed at Dana-Farber Cancer Institute from January 2015 to June 2022. We identified 5 cases of mogamulizumab-associated myositis and/or myocarditis (MAM/Mc), 2 additionally affected by myasthenia gravis, among 42 patients with T-cell lymphoma. Three cases experienced ­mogamulizumab-associated rash (MAR) prior to developing MAM/Mc. The incidence (n = 5/42, 11.9%) of muscular mogamulizumab-associated irAEs may be higher than has been previously reported in clinical trials and may be of late onset (a median of 5 cycles and as late as 100 days from the last infusion). We highlight the utility of IVIG, together with systemic corticosteroids, for the treatment of these potentially fatal side effects associated with mogamulizumab therapy.
Multilayered regulation of developmentally programmed pre-anthesis tip degeneration of the barley inflorescence
Authors: Shanmugaraj Nandhakumar , Rajaraman Jeyaraman , Kale Sandip , Kamal Roop , Huang Yongyu , Thirulogachandar Venkatasubbu , Garibay-Hernández Adriana , Budhagatapalli Nagaveni , Tandron Moya Yudelsy Antonia , Hajirezaei Mohammed R , Rutten Twan , Hensel Götz , Melzer Michael , Kumlehn Jochen , von Wirén Nicolaus , Mock Hans-Peter , Schnurbusch Thorsten 
Published: June 2023

AbstractLeaf and floral tissue degeneration is a common feature in plants. In cereal crops such as barley (Hordeum vulgare L.), pre-anthesis tip degeneration (PTD) starts with growth arrest of the inflorescence meristem dome, which is followed basipetally by the degeneration of floral primordia and the central axis. Due to its quantitative nature and environmental sensitivity, inflorescence PTD constitutes a complex, multilayered trait affecting final grain number. This trait appears to be highly predictable and heritable under standardized growth conditions, consistent with a developmentally programmed mechanism. To elucidate the molecular underpinnings of inflorescence PTD, we combined metabolomic, transcriptomic, and genetic approaches to show that barley inflorescence PTD is accompanied by sugar depletion, amino acid degradation, and abscisic acid responses involving transcriptional regulators of senescence, defense, and light signaling. Based on transcriptome analyses, we identified GRASSY TILLERS1 (HvGT1), encoding an HD-ZIP transcription factor, as an important modulator of inflorescence PTD. A gene-edited knockout mutant of HvGT1 delayed PTD and increased differentiated apical spikelets and final spikelet number, suggesting a possible strategy to increase grain number in cereals. We propose a molecular framework that leads to barley PTD, the manipulation of which may increase yield potential in barley and other related cereals.
BMP7 expression in mammalian cortical radial glial cells increases the length of the neurogenic period
Authors: Li Zhenmeiyu , Liu Guoping , Yang Lin , Sun Mengge , Zhang Zhuangzhi , Xu Zhejun , Gao Yanjing , Jiang Xin , Su Zihao , Li Xiaosu , Yang Zhengang 
Published: June 2023

Abstract
The seat of human intelligence is the human cerebral cortex, which is responsible for our exceptional cognitive abilities. Identifying principles that lead to the development of the large-sized human cerebral cortex will shed light on what makes the human brain and species so special. The remarkable increase in the number of human cortical pyramidal neurons and the size of the human cerebral cortex is mainly because human cortical radial glial cells, primary neural stem cells in the cortex, generate cortical pyramidal neurons for more than 130 days, whereas the same process takes only about 7 days in mice. The molecular mechanisms underlying this difference are largely unknown. Here, we found that bone morphogenic protein 7 (BMP7) is expressed by increasing the number of cortical radial glial cells during mammalian evolution (mouse, ferret, monkey, and human). BMP7 expression in cortical radial glial cells promotes neurogenesis, inhibits gliogenesis, and thereby increases the length of the neurogenic period, whereas Sonic Hedgehog (SHH) signaling promotes cortical gliogenesis. We demonstrate that BMP7 signaling and SHH signaling mutually inhibit each other through regulation of GLI3 repressor formation. We propose that BMP7 drives the evolutionary expansion of the mammalian cortex by increasing the length of the neurogenic period.
Nuclear masses and the equation of state of nuclear matter
Authors: Oyamatsu Kazuhiro 
Published: June 2023

Abstract
The incompressible liquid-drop (ILD) model reproduces masses of stable nuclei rather well. Here we show how the ILD volume, surface, symmetry, and Coulomb energies are related to the equation of state of nuclear matter using the Oyamatsu–Iida (OI) macroscopic nuclear model, which has reasonable many-body energy and isoscalar inhomogeneity gradient energy. We use 304 update interactions, covering wide ranges of the incompressibility K0 of symmetric matter and the density slope of symmetry energy L, which fit almost equally empirical mass and radius data of stable nuclei. Thus, the K0 and L dependences are nearly frozen in stable nuclei as in the ILD model, leading to clear correlations among interaction and saturation parameters. Furthermore, we assume that the surface energy of the OI model is twice as large as the gradient energy using the size equilibrium conditions of the ILD and OI models. Then, the four energies of the ILD and OI models agree well for stable nuclei with A ≳ 40. Meanwhile, the OI model with L ≲ 100 MeV predicts the latest mass data better than those of stable nuclei, and we suggest 20 ≲ L ≲ 90 MeV, although the lower boundary is not constrained well.
Chiral anomaly as a composite operator in the gradient flow exact renormalization group formalism
Authors: Miyakawa Yuki , Sonoda Hidenori , Suzuki Hiroshi 
Published: June 2023

Abstract
The gradient flow exact renormalization group (GFERG) is an idea that incorporates gauge-invariant gradient flows into the formalism of the exact renormalization group (ERG). GFERG introduces a Wilson action with a cutoff while keeping the vector gauge invariance manifestly. The details of the formalism are still to be worked out. In this paper, we apply GFERG to construct the Wilson action of massless Dirac fermions under the background chiral gauge fields. By formulating the chiral anomaly as a “composite operator”, we make the scale invariance of the anomaly manifest. We argue that the same result extends to QCD.
Small fractional parts of binary forms
Authors: Yeon Kiseok 
Published: June 2023

Abstract
We obtain bounds on fractional parts of binary forms of the shape $$\Psi(x,y)=\alpha_k x^k+\alpha_l x^ly^{k-l}+\alpha_{l-1}x^{l-1}y^{k-l+1}+\cdots+\alpha_0 y^k$$ with $\alpha_k,\alpha_l,\ldots,\alpha_0\in{\mathbb R}$ and $l\leq k-2.$ By exploiting recent progress on Vinogradov’s mean value theorem and earlier work on exponential sums over smooth numbers, we derive estimates superior to those obtained hitherto for the best exponent σ, depending on k and $l,$ such that $$ \min_{\substack{0\leq x,y\leq X\\(x,y)\neq (0,0)}}\|\Psi(x,y)\|\leq X^{-\sigma+\epsilon}. $$
Effect of the traffic-light system on nutrition labeling in processed food products in the Ecuadorian population
Authors: Sarasty Oscar , Carpio Carlos , Cabrera Tania 
Published: June 2023

Abstract
The 2012 Ecuadorian National Nutrition and Health Survey found that a high proportion of the country's population is overweight or obese. To address this health issue, in 2013, the Ecuadorian government implemented the use of a mandatory traffic-light (TL) nutritional labeling to be displayed on all processed food and beverages for sale in the country. We aimed to evaluate Ecuadorian consumers’ preferences for the nutritional attributes represented in the TL nutritional labels. In this cross-sectional study, 1,152 Ecuadorian consumers aged 18 and older in charge of food purchases completed an online survey. Results of a choice experiment with yogurt products revealed strong preferences and willingness to pay for yellow and green labels reaching price premiums of $1.15 for fat and $1.34 for sugar relative to red labels. The study provides evidence that consumers have high understanding of the TL nutritional labeling and prefer products with colors representing healthier alternatives.
Resolving Failed Banks: Uncertainty, Multiple Bidding and Auction Design
Authors: Allen Jason , Clark Robert , Hickman Brent , Richert Eric 
Published: June 2023

Abstract
The FDIC resolves insolvent banks with scoring auctions. Although the structure of the scoring rule is known to bidders, they are uncertain about how the FDIC trades off different bid components. Scoring-rule uncertainty motivates bidders to submit multiple bids for the same failed bank. To evaluate the effects of uncertainty and multiple bidding for FDIC costs, we develop a methodology for analysing multidimensional bidding when the auctioneer’s scoring weights are unknown to bidders. We estimate private valuations for failed-bank assets during the great financial crisis and compute counterfactuals in the absence of scoring uncertainty. Our findings imply a substantial reduction in FDIC resolution costs of between 29.8% ($8.2 billion) and 44.6% ($12.3 billion). These savings can reduce policy-driven banking-sector distortions, since FDIC resolution costs are covered either through special levies on banks or through loans from the US Treasury. Our analyses also shed new light on optimal bid portfolio choice in combinatorial auctions.
From improved sleep regularity to reduced sleep complaints and mental health conditions: a population-based interventional study using a smartphone-based virtual agent
Authors: Coelho Julien , Pecune Florian , Levavasseur Yannick , De Sevin Etienne , D’incau Emmanuel , Sagaspe Patricia , Sanchez-Ortuño Maria-Montserrat , Micoulaud-Franchi Jean-Arthur , Philip Pierre 
Published: June 2023

Abstract

Study Objectives
To explore the effect of sleep regularity on sleep complaints and mental health conditions (i.e. insomnia, fatigue, anxiety, and depressive symptoms) in a population-based interventional study using a smartphone-based virtual agent.

Methods
A populational cohort based on the Kanopée application, which provided interactions with a virtual companion to collect data on sleep and make personalized recommendations to improve sleep over 17 days. A pre-intervention sleep diary and interview were used for cross-sectional analysis (n = 2142), and a post-intervention sleep diary and interview were used for longitudinal analysis (n = 732). The intra-individual mean (IIM) and standard deviation (ISD) of total sleep time (TST) were calculated to measure sleep quantity and sleep regularity.

Results
The mean age at baseline was 49 years, 65% were female, 72% reported insomnia, 58% fatigue, 36% anxiety, and 17% depressive symptoms. Before the intervention, irregular and short sleep was associated with a higher likelihood of insomnia (Relative risk [RR] = 1.26 [1.21–1.30] for irregular TST and RR = 1.19 [1.15–1.23] for short TST), fatigue, anxiety, and depressive symptoms. After the intervention, the IIM of the TST increased while the ISD of the TST and sleep complaints and mental health conditions decreased. More regular TST was associated with reduced insomnia and depressive symptoms (RR = 1.33 [1.10–1.52] and RR = 1.55 [1.13–1.98], respectively).

Conclusions
Our results reveal a longitudinal association between sleep regularity and sleep complaints and mental health conditions. Policymakers, health professionals, and the general population should be aware that, beyond its positive effect on sleep health, regular sleep could promote mental health.
Brokers and Boundary Managers: School Expulsions amid the Non-Punitive Turn
Authors: Gleit Rebecca D 
Published: June 2023

Abstract
Like many American institutions, K–12 schools are increasingly embracing a rhetoric of non-punitiveness and seeking to supply resources instead of imposing harsh punishment. Using ethnographic data from a diverse, suburban, well-resourced public high school, I explore how institutional actors manage this central role in the provision of goods and services. I find that school staff lack the capacity to successfully serve as brokers for all their constituents, forcing decisions about how to allocate their limited resources. Staff navigate these constraints by strategically managing the boundaries of the institution, redefining who gets to remain a member and who they will continue brokering for. I describe how and when these exclusions occur and show that students from less advantaged backgrounds are at higher risk of expulsion because they depend more on the school for resources than their privileged peers. Further, informal methods of exclusion become favored in this non-punitive pivot, meaning that official data likely undercount the number of students forcibly removed from their schools. As institutions take on more resource brokering amid the turn towards non-punitiveness, the decisions of boundary managers – those actors with the power to enroll and expel members – become increasingly consequential for the allocation of public resources.
17Visual Culture
Authors: Gordon-Orr Rose 
Published: June 2023

AbstractThe unauthorized movement of people across national borders, on land and sea, continues to be a matter of life and death for many migrants. In 2022, more than 2,000 people died attempting to cross the Mediterranean (Statista [2023]) and more than 800 died on the US–Mexico border (Villarreal [2022]). In both Europe and the US, migration remains a significant political issue and one that has a strong visual component: it is through visual representations of boats, bodies, and borders that most non-migrants apprehend the phenomenon. Visual surveillance from the air and at crossing points is a key part of state attempts to control migration. With the increasing availability of smartphones and social media platforms, migrants themselves are also visually documenting and sharing their experiences. This chapter focuses on six texts published within 2022 which explore aspects of visual culture in relation to migration. This has several facets: representation of migrants and associated colonial tropes; visual and ‘postvisual’ surveillance of migrant bodies; and digital self-representation and reclaiming the gaze through creative practices. In line with this, the chapter is divided into three sections: 1. Visual Policing; 2. Visual Narration; 3. Artistic Disruptions.
PREDITING THE RISK OF FRACTURE ASSOCIATED WITH ANTIHYPERTENSIVE TREATMENT: DEVELOPMENT OF THE STRATIFY-FRACTURE PREDICTION MODEL
Authors: Wang Ariel , Koshiaris Constantinos , Stevens Richard , Hobbs F.D. Richard , McManus Richard J. , Sheppard James P. 
Published: June 2023

Objective:
The benefits of antihypertensive treatment are well known, but less is known about the potential risk of harm from antihypertensive medication. The STRAtifying Treatments. In the multi-morbid Frail elderlY (STRATIFY) study aimed to better understand the harms of antihypertensive treatment by quantifying an individual's baseline risk of different serious adverse events. This current study aimed to develop a prediction model for an individual's risk of hospitalisation or death from fracture.

Design and method:
Participants aged > = 40 years, registered to a UK primary care practice within the Clinical Pr: actice Research Datalink (CPRD) GOLD database, with at least one blood pressure measurement between 130-179 mm Hg were included in this cohort study. The outcome investigated was fracture that led to hospital admission or death within 10 years after the index date. The (prespecified) predictor variables based on the literature and expert opinions were patient characteristics, history of falls and fractures (from the age of 40), diagnosis of osteoporosis and rheumatoid arthritis, other comorbidities, and prescribed medications (including antihypertensive medications). Multiple imputation was used to account for missing data. The primary analysis used a Fine-Gray competing risks approach to adjust death from other causes. Results were reported as subdistribution hazard ratios (SHR).

Results:
A total of 1,772,601 participants were included, with a mean age of 59 years and median follow-up of 6.1 years. The 10-year incidence of fracture was 1.4%. All antihypertensive medications were significantly associated with the risk of fracture, as were a number of patient characteristics and co-morbidities (detailed in Table 1). Potential predictors with no significant association were chronic renal disease, mobility and transfer problems, hypogonadism, vitamin D deficiency and aromatase inhibitors. SHRs and 95% confidence intervals for the predictors are shown in Table 1.

Conclusions:
In this study, we identified a number of predictors of fracture using UK electronic health record and quantified an individual's baseline risk of fracture. The external validation of this model will use a different database (CPRD AURUM). Our findings could inform clinicians as to when it is appropriate to prescribe and deprescribe antihypertensive treatment.
CARDIOVASCULAR RISK, METABOLIC PROFILE AND INFLAMMATORY FINGERPRINT OF OBESE SUBJECTS UNDERGOING BARIATRIC SURGERY
Authors: Burrello Jacopo , Gonzalez Mary Julieth , Airale Lorenzo , Burrello Alessio , Kostler Thomas , Zingg Urs , Barile Lucio , Osto Elena 
Published: June 2023

Objective:
Bariatric surgery has emerged as effective treatment for obesity not only for the substantial and durable weight loss, but also by improving several obesity-related comorbidities, including hypertension. Extracellular vesicles (EVs; membrane nanoparticles released by cells) and their cargo reflect endothelial dysfunction and inflammation, and may be used as indicators of post-surgical outcomes in these patients. The aim of the present study was to exploit an EV signature to assess cardiovascular (CV) risk, metabolic profile, and inflammatory fingerprint before and after bariatric surgery.

Design and method:
The study cohort was composed by 62 patients (age 39 years; 21% males); for each subject, clinical and biochemical parameters, disease status (including diabetes, dyslipidemia, and hypertension), medications, and EV profiling were evaluated at baseline (T0) and 1-/3-years (T1 and T2, respectively), after surgery (sleeve gastrectomy or Roux-en-Y gastric bypass). EVs were isolated from serum by beads-based immuno-capture and analyzed for the expression of 37 membrane-associated antigens.

Results:
After bariatric surgery, patients gradually lost weight from a median of 110 Kg at T0 down to 80 Kg at T2 (cumulative weight loss 31 Kg; 29.9% BMI reduction). Accordingly, the overall CV risk and metabolic-inflammatory profile of patients improved: systolic blood pressure, HbA1c, total cholesterol, triglycerides, LDL, uric acid, white blood cells, and C-reactive protein decreased, while HDL and renal function (expressed as eGFR) increased at follow-up (p < 0.05 for all comparisons); prevalence of hypertension, dyslipidemia, and diabetes decreased together with the number of assumed drugs (anti-hypertensives, statins, hypoglycemic, and anti-platelets agents). Consistently, levels of expression of EV specific markers (CD9-CD63-CD81) and 11 out of the 37 evaluated antigens (mainly from endothelium, platelets, and inflammatory cells) decreased at T1/T2, reflecting changes of main CV risk indicators. Interestingly, lower baseline levels of CD4, CD31, CD40, CD42a, and CD62P were associated to a complete post-surgical outcome, defined as no residual disease without medications, with a BMI at T2 lower than 30 Kg/sqm.

Conclusions:
EV-derived biomarkers reflect the improvement of CV profile in patients who underwent bariatric surgery and may become a new tool to predict post-surgical outcome.
RESULTS OF SIMULTANEOUS LEFT AND RIGHT UPPER ARM 24-HOUR AMBULATORY BLOOD PRESSURE MEASUREMENT: A WAKE UP-CALL FOR BETTER HYPERTENSION MANAGEMENT
Authors: Bothe Tomas L , Patzak Andreas , Pilz Niklas 
Published: June 2023

Objective:
Cuff-based 24-hour ambulatory blood pressure (BP) measurement is considered as the gold standard for hypertension diagnosis and treatment monitoring, its clinical value being ubiquitously accepted. This study wants to quantify the measurement discrepancies in simultaneous and synchronized 24-hour ambulatory BP measurements on both arms. Identifying and understanding measurement uncertainties could improve future hypertension management and further stimulate research on alternative, cuff-less systems with adequate measurement precision.

Methods:
We conducted simultaneous 24-hour ambulatory BP measurements on both arms in 52 healthy young adults. Broadly used and validated cuff-devices (BoSo TM-2430) were synchronized to start BP measurement within one second of each other. Further, we recorded cuff-pressures of both cuff-based devices and the hydrostatic pressure differences between both cuffs throughout the recording. We then scored pressure curves for disturbances (e.g., pressure spikes during deflation) and were able to correct measurements for hydrostatic differences between the arms. This enabled us to not only quantify the extent of measurement inaccuracy but to describe its origins and possible countermeasures.

Design and method:
Measured BP levels from left and right arm showed limits of agreement in the Bland Altman Plot of > 33 mmHg for systolic and > 30 mmHg for diastolic values over 24 h. Daytime values deviated more than nocturnal values (systolic: > 35 mmHg vs. > 27 mmHg systolic, and diastolic: > 32 mmHg vs. > 24 mmHg, respectively). Linear regression retrieved R2 = 0.39 (p < 0.001) for systolic and R2 = 0.20 (p < 0.001) for diastolic values. Exclusion of artefactual cuff pressure curves improved limits of agreement to > 23 mmHg for systolic and > 19mmHg for diastolic measurements. Subsequently, it improved correlation coefficients to R2 = 0.54 (p < 0.001) for systolic and R2 = 0.35 (p < 0.001) for diastolic values. Correction of hydrostatic differences between the arms had a negligible effect on limits of agreement and strength of correlation.

Results:
Comparison of synchronized 24-hour BP measurements obtained on both arms showed large measurement uncertainties with possible implications on clinical grading of hypertension and dipping pattern. Exclusion of artefactual cuff pressure curves, not detected by the conventional software of BP devices, mitigates the effect but cannot eliminate worrying discrepancies. These results strongly support the need to further investigate the clinical implications of BP measurement uncertainty. They should further stimulate research on alternative means of BP measurement which might overcome some of the problems related to cuff-based BP monitoring.