bluuebunny/crossref_metadata_2025_split huggingface dataset:
Persisting Gaps in Optimal Care of Stage III Non-small Cell Lung Cancer: An Australian Patterns of Care Analysis
Authors: Woodford Katrina , Koo Kendrick , Reynolds John , Stirling Robert G , Harden Susan V , Brand Margaret , Senthi Sashendra 
Published: December 2022

AbstractBackgroundWide variation exists globally in the treatment and outcomes of stage III patients with non–small cell lung cancer (NSCLC). We conducted an up-to-date patterns of care analysis in the state of Victoria, Australia, with a particular focus on the proportion of patients receiving treatment with radical intent, treatment trends over time, and survival.Materials and MethodsStage III patients with NSCLC were identified in the Victorian Lung Cancer Registry and categorized by treatment received and treatment intent. Logistic regression was used to explore factors predictive of receipt of radical treatment and the treatment trends over time. Cox regression was used to explore variables associated with overall survival (OS). Covariates evaluated included age, sex, ECOG performance status, smoking status, year of diagnosis, Australian born, Aboriginal or Torres Strait Islander status, socioeconomic status, rurality, public/private status of notifying institution, and multidisciplinary meeting discussion.ResultsA total of 1396 patients were diagnosed between 2012 and 2019 and received treatment with radical intent 67%, palliative intent 23%, unknown intent 5% and no treatment 5%. Radical intent treatment was less likely if patients were &gt;75 years, ECOG ≥1, had T3-4 or N3 disease or resided rurally. Surgery use decreased over time, while concurrent chemoradiotherapy and immunotherapy use increased. Median OS was 38.0, 11.1, and 4.4 months following radical treatment, palliative treatment or no treatment, respectively.ConclusionAlmost a third of stage III patients with NSCLC still do not receive radical treatment. Strategies to facilitate radical treatment and better support decision making between increasing multimodality options are required.
The MYB59 transcription factor negatively regulates salicylic acid- and jasmonic acid-mediated leaf senescence
Authors: He Shuangcheng , Zhi Fang , Min Yuanchang , Ma Rong , Ge Ankang , Wang Shixiang , Wang Jianjun , Liu Zijin , Guo Yuan , Chen Mingxun 
Published: December 2022

Abstract
Leaf senescence is the final stage of leaf development and is affected by various exogenous and endogenous factors. Transcriptional regulation is essential for leaf senescence, however, the underlying molecular mechanisms remain largely unclear. In this study, we report that the transcription factor MYB59, which was predominantly expressed in early senescent rosette leaves, negatively regulates leaf senescence in Arabidopsis (Arabidopsis thaliana). RNA sequencing revealed a large number of differentially expressed genes involved in several senescence-related biological processes in myb59-1 rosette leaves. Chromatin immunoprecipitation and transient dual-luciferase reporter assays demonstrated that MYB59 directly repressed the expression of SENESCENCE ASSOCIATED GENE 18 and indirectly inhibited the expression of several other senescence-associated genes to delay leaf senescence. Moreover, MYB59 was induced by salicylic acid (SA) and jasmonic acid (JA). MYB59 inhibited SA production by directly repressing the expression of ISOCHORISMATE SYNTHASE 1 and PHENYLALANINE AMMONIA-LYASE 2 and restrained JA biosynthesis by directly suppressing the expression of LIPOXYGENASE 2, thus forming two negative feedback regulatory loops with SA and JA and ultimately delaying leaf senescence. These results help us understand the novel function of MYB59 and provide insights into the regulatory network controlling leaf senescence in Arabidopsis.
A brassinosteroid transcriptional regulatory network participates in regulating fiber elongation in cotton
Authors: Liu Le , Chen Guoquan , Li Shengdong , Gu Yu , Lu Lili , Qanmber Ghulam , Mendu Venugopal , Liu Zhao , Li Fuguang , Yang Zuoren 
Published: December 2022

AbstractBrassinosteroids (BRs) participate in the regulation of plant growth and development through BRI1-EMS-SUPPRESSOR1 (BES1)/BRASSINAZOLE-RESISTANT1 (BZR1) family transcription factors. Cotton (Gossypium hirsutum) fibers are highly elongated single cells, and BRs play a vital role in the regulation of fiber elongation. However, the mode of action on how BR is involved in the regulation of cotton fiber elongation remains unexplored. Here, we generated GhBES1.4 over expression lines and found that overexpression of GhBES1.4 promoted fiber elongation, whereas silencing of GhBES1.4 reduced fiber length. DNA affinity purification and sequencing (DAP-seq) identified 1,531 target genes of GhBES1.4, and five recognition motifs of GhBES1.4 were identified by enrichment analysis. Combined analysis of DAP-seq and RNA-seq data of GhBES1.4-OE/RNAi provided mechanistic insights into GhBES1.4-mediated regulation of cotton fiber development. Further, with the integrated approach of GWAS, RNA-seq, and DAP-seq, we identified seven genes related to fiber elongation that were directly regulated by GhBES1.4. Of them, we showed Cytochrome P450 84A1 (GhCYP84A1) and 3-hydroxy-3-methylglutaryl-coenzyme A reductase 1 (GhHMG1) promote cotton fiber elongation. Overall, the present study established the role of GhBES1.4-mediated gene regulation and laid the foundation for further understanding the mechanism of BR participation in regulating fiber development.
“An Ordinary Case of Discipline”: Deputizing White Americans and Punishing Indian Men at the Carlisle Indian Industrial School, 1900–1918
Authors: Whitt Sarah A 
Published: December 2022

Abstract
The Carlisle Indian Industrial School (1879-1918) is often remembered as the first residential school for American Indian children and youth forcibly removed from their communities as a part of the U.S. government’s policy of so-called assimilation. In addition to “school-aged” youth, however, American Indian women and men eighteen years of age and older comprised a substantial proportion, and from 1912 to 1918 the majority, of Carlisle’s “student” body. In centering the disciplinary documents of American Indian men, this article examines a seeming paradox: Carlisle employees, U.S. officials, and U.S. citizens punished older male enrollees for enacting the very ideals that Carlisle claimed to be teaching them. Simultaneously, archival records reveal that White Americans profited off of their participation in the punitive structure of the settler state. Viewed through the prism of adult Indian men’s punitive experiences, Carlisle served many non-educational purposes as a carceral place of Indigenous punishment that deputized White Americans, helped maintain White hegemony, and furthered explicitly settler colonial objectives. The punitive patterns explored here show how Carlisle benefited the settler society by increasing the reach of its power over tribal nations—a fact that reveals the interlocking and interchangeable nature of carceral facilities, and which further demonstrates how Indigenous institutionalization was inherent to U.S. settler colonialism in this era.
Chronic pain conditions and use of analgesics among nursing home patients with dementia
Authors: Myrenget Martin Elstad , Borchgrevink Petter C. , Rustøen Tone , Butler Stephen , Thorsvik Dagfinn , Småstuen Milada C. , Sandvik Reidun 
Published: December 2022

Abstract
Pain management for patients with dementia is challenging because many experience pain while being unable to communicate their pain. The aim of this study was to describe pain, pain management, and to perform a thorough clinical examination of chronic pain conditions among patients with dementia. Residents (n = 498) from 12 nursing homes were assessed for dementia (Clinical Dementia Rating scale [CDR]) and for pain with the Mobilization-Observation-Behavior-Intensity-Dementia-2 (MOBID-2) assessment form. Of all examined nursing home patients with dementia, 68% had moderate or severe chronic pain. The final study population (n = 262) with a CDR score of ≥1 and a MOBID-2 score of ≥3 were examined by pain expert physicians for chronic pain and categorized according to the International Classification of Disease (ICD-10/-11) classification systems. More than half (54.6%) had chronic pain conditions without underlying disease classified as chronic primary pain by ICD-11. Chronic widespread pain was the most prevalent (14.5%) followed by nonspecific pain from the back (13.4%), whereas the most prevalent chronic secondary pain conditions were chronic pain caused by osteoarthritis (15.4%) and stroke (8.0%). One-fourth received opioids, which was significantly associated with severe pain (P < 0.001) compared with moderate pain, although no significant association was found between opioid use and the type of pain condition. Although knowledge of the severity and specific types of pain conditions is recommended to direct the choice of treatment, these areas are not sufficiently explored in the nursing home populations with dementia and may hinder a better treatment of pain in this population.
Neural, physiological and behavioral correlates of empathy for pain in Tourette syndrome
Authors: Weiblen Ronja , Robert Carina , Petereit Pauline , Heldmann Marcus , Münte Thomas F. , Münchau Alexander , Müller-Vahl Kirsten , Krämer Ulrike M. 
Published: December 2022

AbstractPersons with Tourette syndrome show altered social behaviors, such as echophenomena and increased personal distress in emotional situations. These symptoms may reflect an overactive mirror neuron system, causing both increased automatic imitation and a stronger tendency to share others’ emotions. To test this, we measured the individual level of echophenomena with a video protocol and experimentally induced empathy for pain in 21 participants with Tourette syndrome and 25 matched controls.In the empathy for pain paradigm, pictures of hands and feet in painful or neutral situations were presented, while we measured participants’ EEG and skin conductance response. Changes in somatosensory mu suppression during the observation of the pictures and pain ratings were compared between groups and correlations were calculated with the occurrence of echophenomena, self-reported empathy and clinical measures.Our Tourette syndrome sample showed significantly more echophenomena than controls, but the groups showed no behavioral differences in empathic abilities. However, controls, but not patients with Tourette syndrome, showed the predicted increased mu suppression when watching painful compared to neutral actions. While echophenomena were present in all persons with Tourette syndrome, the hypothesis of an overactive mirror neuron system in Tourette syndrome could not be substantiated. On the contrary, the Tourette syndrome group showed a noticeable lack of mu attenuation in response to pain stimuli. In conclusion, we found a first hint of altered processing of others’ emotional states in a brain region associated with the mirror neuron system.
Toward development of comprehensive national disaster response plans: an evaluation of Nigeria's national disaster response plan, 2002
Authors: Mashi Sani , Idris Kabir , Kazaure Isa Abubakar Yakubu 
Published: December 2022

PurposeDevelopment of a disaster response plan at a national level is regarded as the best way to undertake country-level disaster management in a well-coordinated manner, involving all stakeholders in well-built networks. Where developed national disaster response plans (NDRPs) are to be subjected to evaluative assessments from time to time to establish their strengths and weaknesses in disaster response processes. Only about 20 of the world's 195 countries have NDRPs, and only three of them have undergone some form of evaluation. This paper contributes toward filling this gap by evaluating the NDRP of the Federal Republic of Nigeria. Lessons from the implementation of this NDRP will help guide the development of the plans in countries where they do not yet exist.Design/methodology/approachNetwork and qualitative content analysis was employed to subject the Nigerian NDRP to critical evaluation using standards already established in the literature for the development of management networks and their use in disaster response. The experiences of other countries with developed NDRPs were also used to guide an effective evaluation process.FindingsFindings of the study show that the Nigerian NDRP is deficient in many respects, particularly in the areas of weak development of networks, absence of roles-differentiation for various stakeholders, lack of specified achievable and hence monitorable targets, objectives and outcomes and absence of detailed response plans for specific disaster types. The plan needs to therefore be subjected to a detailed multidisciplinary and multi-stakeholder review to get it strengthened.Originality/valueThis is the first attempt to conduct an evaluative assessment of Nigeria's NDRP and the 4th in the world. The study's findings can help not only to strengthen Nigeria's NDRP, but also to develop similar plans in other countries around the world.
The use of notebooks by Bangladeshi rural women to preserve information
Authors: Frings-Hessami Viviane 
Published: December 2022

PurposeThis article uses continuum theory to analyse how Bangladeshi rural women who participated in an information and communication technology for development (ICT4D) project accessed and preserved information during and after the end of the project.Design/methodology/approachSemi-structured interviews were conducted over the phone with a sample of the project participants two years after the end of the ICT4D project, and a survey of all the participants in one village was conducted face-to-face by one of the project participants using a questionnaire developed by the author.FindingsThe majority of the participants used paper notebooks to write down information that they received in digital format during the project as a guarantee against the fragility of digital data and continued to use them to access and preserve information after the end of the project.Practical implicationsThe author suggests that the application of proactive appraisal during the planning stage and throughout ICT4D projects can ensure that the longer-term needs of the communities for information and their capacities to use specific formats will be considered.Originality/valueThe author applies the continuum theory concept of proactive appraisal to the use of information in an ICT4D context and argues that it can help with assessing the information needs of marginalised communities and the technologies and formats that should be used to ensure that the information provided to them will remain accessible for as long as they need it.
The dynamic nature of leader–member exchange relationships in health-care organizations
Authors: Hirvi Sari , Laulainen Sanna , Junttila Kristiina , Lammintakanen Johanna 
Published: December 2022

Purpose
This study aims to make visible the dynamic nature of leader–member exchange (LMX) in the changing realm of health-care leadership.

Design/methodology/approach
The qualitative study used an open questionnaire, which was distributed amongst nursing staff and managers at a Finnish public university hospital.

Findings
The participants described partly LMX theory, but the leader-member relationship was also influenced by the organizational culture and the existing management practices. Nursing staff were found to have a more variable and dynamic role in the LMX relationship than has previously been reported. The research therefore provided novel information for the field of health-care research.

Research limitations/implications
The presented research was limited by the content of the data, as the collected single narratives were rather short; however, the fact that a large number of narratives were collected from diverse participants strengthened the ability to reliably answer the research questions.

Practical implications
Although the participants described partly LMX theory, the leader–member relationship is also influenced by the organizational culture and existing management practices; the finding that nurses have more variable roles in LMX relationships in the health-care context was new insight in this field. Therefore, the presented findings can help decision-makers change the current, perhaps antiquated, leadership practices at health-care organizations.

Originality/value
This study provides new insight into the field of LMX research in terms of the important role of nursing staff, the organizational factors that influence the LMX relationship and the dynamic nature of LMX relationships.
Rethinking training transfer: a practice theory perspective
Authors: Ben Zammel Ibticem , Hachana Rim 
Published: December 2022

Purpose
By positioning this study within the theoretical lenses of Bourdieu’s practice theory, this paper aims to provide a more contextual understanding of training transfer (TT) with a particular focus on the duality between objectivity and subjectivity that characterize social structures within two different fields (a public post office company and a multinational evolving in the ICT high-tech sector).

Design/methodology/approach
Multiple case study.

Findings
The findings demonstrate that TT cannot be dissociated from social interaction dynamics in the workplace, where objective and subjective structures play a strategic role. In fact, capital dispatching, power disparities and cultural imperatives influence TT practice in both cases. However, this influence differs from one field to another.

Practical implications
Top management team should pay more attention to power and particularly to symbolic power as it can influence TT intentions and effectiveness. They must be aware that not only the economic capital is sought after but also the cultural and the symbolic capital.

Originality/value
This study aims at lessening the gap between theory and practice on the TT problem, in an effort to increase comprehension of the social roots of the transferring process. This research deepens the analysis of the complexity of socialization structuring TT practice in two different fields.
Silencing of circ‐NT5C2 retards the progression of IL‐1β–induced osteoarthritis in an in vitro cell model by targeting the miR‐142‐5p/NAMPT axis
Authors: Zhang Wei , Wang Yan‐dong , Xing Yong‐jun , Liu Peng‐jun , Yang Jian‐hui 
Published: December 2022

AbstractOsteoarthritis (OA) is a degenerative disease that occurs mostly in the elderly, and its specific pathogenesis is still unknown, but recent studies have found that circular RNA generally display aberrant expression in OA. Our study explored the expression characteristics and mechanism of action of circ‐NT5C2 in OA. Circ‐NT5C2, microRNA‐142‐5p (miR‐142‐5p), and nicotinamide phosphoribosyltransferase (NAMPT) mRNA levels were measured using RT‐qPCR. Western blot was employed to assess the protein level of NAMPT and extracellular matrix (ECM) production‐related markers. The viability, proliferation, apoptosis and inflammation were examined using 3‐(4, 5‐dimethylthiazol‐2‐yl)‐2, 5‐diphenyltetrazolium bromide (MTT) assay, 5‐ethynyl‐2′‐deoxyuridine (EdU) assay, flow cytometry, and enzyme‐linked immunosorbent assay, respectively. Relationship between miR‐142‐5p and circ‐NT5C2 or NAMPT was demonstrated by dual‐luciferase reporter system and RNA immunoprecipitation assay. We reported that circ‐NT5C2 and NAMPT were greatly upregulated, and miR‐142‐5p level was constrained in OA tissues and in a cell model. Circ‐NT5C2 silencing alleviated IL‐1β‐induced inhibitory effects on chondrocyte proliferation and ECM generation, meanwhile the promotional role of IL‐1β on chondrocyte apoptosis and inflammation was also weakened. The targeting relationship of miR‐142‐5p with either circ‐NT5C2 or NAMPT was confirmed. Knockdown of miR‐142‐5p reversed the suppressive effects of circ‐NT5C2 silencing on the OA progression in vitro, and NAMPT overexpression also attenuated the effects of miR‐142‐5p upregulation in an OA cell model. Collectively, circ‐NT5C2 accelerated the OA process by targeting the miR‐142‐5p/NAMPT axis. This study provides valuable information to find a better treatment for OA.
Assessment of the impact of noise magnitude and bandwidth variations on a probabilistic inversion of reflection seismic data
Authors: Heidari Hamed , Madsen Rasmus Bødker , Amini Hamed , Hansen Thomas Mejer , Emami‐Niri Mohammad , Amini Navid 
Published: December 2022

AbstractAccounting for an accurate noise model is essential when dealing with real data, which are noisy due to the effect of environmental noise, failures and limitations in data acquisition and processing. Quantifying the noise model is a challenge for practitioners in formulating an inverse problem, and usually, a simple Gaussian noise model is assumed as a white noise model. Here we propose a pragmatic approach to use an estimated seismic wavelet to capture the correlated noise model (coloured noise) for the processed reflection seismic data. We assess the proposed method through a direct inversion of post‐stack seismic data associated with a carbonate reservoir of an oil field in southwest Iran to porosity, using a probabilistic sampling‐based inversion algorithm. In the probabilistic formulation of the inverse problem, we assume eight different noise models with varying bandwidth and magnitude and investigate the corresponding posterior statistics. The results indicate that if the correlated nature of the noise samples is ignored in the noise covariance matrix, some unrealistic features are generated in porosity realizations. In addition, if the noise magnitude is underestimated, the inversion algorithm overfits the data and generates a biased model with low uncertainty. Furthermore, by considering an imperfect bandwidth for the noise model, the error is propagated to the posterior realizations. Assuming the correlated noise in a probabilistic inversion resolves these issues significantly. Therefore, for inverting real seismic data where the estimation of the magnitude and correlations of the noise is not straightforward, the wavelet, which is estimated from the real seismic data, provides a good proxy for describing the correlation of the noise samples or equivalently the bandwidth of the noise model. In addition, it might be better to overestimate the noise magnitude than to underestimate it. This is true especially for an uncorrelated noise model and to a lesser degree also for the correlated noise model.
Locating power in party leader selection
Authors: Aylott Nicholas , Bolin Niklas 
Published: December 2022

AbstractIn this article, the aim is to enhance our understanding of who has power over leader selection in political parties. To this end, we apply an analytical framework in which the selection process is divided into three phases: gatekeeping, preparation and decision. The focus is on determining the extent to which each of these phases is influential for the outcome and thereby locating the distribution of intra‐party power. Underpinning the analysis is the conviction that the comparison of leader selection is too limited if it relies solely on information about formal procedures, including the composition of the selectorate. We should also take the preselection phase of leader selection into account. Empirically, we examine a sample of recent selection processes in European parliamentary democracies. In contrast to previous research on intra‐party politics, which has suggested an ascendancy of the party in public office, our results suggest an enduring strength of the party on the ground and the party in the central office.