bluuebunny/crossref_metadata_2025_split huggingface dataset:
A 14-year-old patient with Prader-Willi syndrome: a case report
Authors: Marlinna Marlinna , Julia Madarina , Noormanto Noormanto 
Published: March 2023

Prader-Willi Syndrome (PWS) is a disorder resulting from a loss of genetic information on chromosome 15q11.2-q13 inherited from the father. It can be caused by paternal deletions (65-75%) or uniparental maternal disomy (20-30%). The prevalence of PWS is estimated to be 1/10,000 - 1/20,000 births.1 Although its incidence is relatively rare, PWS can cause major health problems for patients and decreased quality of life for their families.
The course of PWS is characterized by severe hypotonia in the neonatal period, severe feeding problems resulting in growth failure, as well as small hands and feet. Hypogonadism manifests as genital hypoplasia, delayed puberty, and infertility. Children with PWS have delayed motor and language development. Most patients have some degree of intellectual disability. Hyperphagia and obesity occur in early childhood. The patient’s excessive eating behavior affects the patient’s and family’s quality of life, and is often responsible for high morbidity and mortality.
Priority Areas for Increasing the Competitiveness of the Agro-Industrial Complex and Environmental Sustainability
Authors: NURMANBETOVA Arailym , ZHUSSUPOV Yerzhan , AKIMBEKOVA Galiya , GRIDNEVA Yelena , KALIAKPAROVA Gulnar , KHAN Yury 
Published: March 2023

The article considers the place of agro-industrial complex of Kazakhstan in the national economic complex of the country, which has certain problems that affect the current state. In the course of the study of the agro-industrial complex the author considered the participation in the formation of the country's GDP, dynamics and structure of gross agricultural output as the main branch of the agro-industrial complex.
As a result, the main problems were identified and the priority tasks to solve the problems of management of the agro-industrial complex, based on the target indicators of development of the agro-industrial complex until 2020, in order to further forecast and model the forecast values until 2025 through the dynamics of gross agricultural production of Kazakhstan for 2016-2020, GDP structure by economic activity, the structure of gross agricultural production by industry, profitability of agricultural production, and indicators of import.
Infinitely many localized semiclassical states for nonlinear Kirchhoff-type equation
Authors: Feng Binhua , Wang Da-Bin , Wu Zhi-Guo 
Published: March 2023

Abstract
We deal with localized semiclassical states for singularly perturbed Kirchhoff-type equation as follows:

−

ε

2

a
+
ε
b

∫

R

3

∣

∇

v

∣

2

d
x

Δ
v
+
V

(

x

)

v
=
P

(

x

)

f

(

v

)

,

x
∈

R

3

,

-\left({\varepsilon }^{2}a+\varepsilon b\mathop{\int }\limits_{{{\mathbb{R}}}^{3}}| \nabla v{| }^{2}{\rm{d}}x\right)\Delta v+V\left(x)v=P\left(x)f\left(v),\hspace{1em}x\in {{\mathbb{R}}}^{3},

where

V
,
P
∈

C

1

(

R

3

,
R

)

V,P\in {C}^{1}\left({{\mathbb{R}}}^{3},{\mathbb{R}})

and bounded away from zero. By applying the penalization approach together with the Nehari manifold approach in the studies of Szulkin and Weth, we obtain the existence of an infinite sequence of localized solutions of higher topological type. In addition, we also give a concrete set as the concentration position of these localized solutions. It is noted that, in our main results,

f

f

only belongs to

C

(

R
,
R

)

C\left({\mathbb{R}},{\mathbb{R}})

and does not satisfy the Ambrosetti-Rabinowitz-type condition.
A new version of the binary star database BDB: Challenges and directions
Authors: Kaygorodov Pavel , Skvortsov Nikolay , Kovaleva Dana , Malkov Oleg 
Published: March 2023

Abstract
In accordance with the principles of open science, the results of the research should remain available for further investigations and practical interaction with them in the research community. Such results include collected initial and obtained data, specifications and implementations of methods applicable to them including data integration rules, and other possible resources. At the same time, the results of research on data should be curated to maintain their relevance, compliance with domain development, and standards in order to make them as useful as possible in the long term. A research support system in the research domain of physics of stellar systems is being developed to provide relevant data and methods, classify them, make them findable, avoid multiple integration of heterogeneous data, and integrate them into ongoing research in the astrophysical community. New catalogues are being added on regular basis, and this process is accompanied by correct cross-identification of the entities. New observational types of binary stars with their features are added to binary star database (https://bdb.inasan.ru).
Application prospect of calcium peroxide nanoparticles in biomedical field
Authors: Wu Xincai , Han Xu , Guo Yang , Liu Qian , Sun Ran , Wen Zhaohui , Dai Changsong 
Published: March 2023

Abstract
In recent years, calcium peroxide (CaO2) has attracted widespread attention in the medical community due to its excellent antitumor and antibacterial properties, and has gradually become a hot research topic in the biomedical field. CaO2 reacts with water (H2O) to produce calcium ion (Ca2+), oxygen (O2), and hydrogen peroxide (H2O2), where Ca2+ is suitable for calcium death caused by calcium overload, O2 is suitable for O2-dependent anticancer therapy, and H2O2 is suitable for H2O2-dependent anticancer therapy. In addition, H2O2 can also be used in the antibacterial field to treat bacterial infections. All these make the CaO2 to become a kind of excellent antitumor and antibacterial drug. This study mainly reviews the preparation and surface modification of CaO2, probes into the latest progress about CaO2 nanoparticles in the field of tumor treatment and antimicrobial therapy. Finally, the challenges that CaO2 still faces in the future research field are clarified, and its prospects are forecasted.
Species-Specific Adaptation for Ongoing High-Frequency Action Potential Generation in MNTB Neurons
Authors: Kladisios Nikolaos , Wicke Kathrin D. , Pätz-Warncke Christina , Felmy Felix 
Published: March 2023

Comparative analysis of evolutionarily conserved neuronal circuits between phylogenetically distant mammals highlights the relevant mechanisms and specific adaptations to information processing. The medial nucleus of the trapezoid body (MNTB) is a conserved mammalian auditory brainstem nucleus relevant for temporal processing. While MNTB neurons have been extensively investigated, a comparative analysis of phylogenetically distant mammals and the spike generation is missing. To understand the suprathreshold precision and firing rate, we examined the membrane, voltage-gated ion channel and synaptic properties inPhyllostomus discolor(bat) and inMeriones unguiculatus(rodent) of either sex. Between the two species, the membrane properties of MNTB neurons were similar at rest with only minor differences, while larger dendrotoxin (DTX)-sensitive potassium currents were found in gerbils. Calyx of Held-mediated EPSCs were smaller and frequency dependence of short-term plasticity (STP) less pronounced in bats. Simulating synaptic train stimulations in dynamic clamp revealed that MNTB neurons fired with decreasing success rate near conductance threshold and at increasing stimulation frequency. Driven by STP-dependent conductance decrease, the latency of evoked action potentials increased during train stimulations. The spike generator showed a temporal adaptation at the beginning of train stimulations that can be explained by sodium current inactivation. Compared with gerbils, the spike generator of bats sustained higher frequency input-output functions and upheld the same temporal precision. Our data mechanistically support that MNTB input-output functions in bats are suited to sustain precise high-frequency rates, while for gerbils, temporal precision appears more relevant and an adaptation to high output-rates can be spared.SIGNIFICANCE STATEMENTNeurons in the mammalian medial nucleus of the trapezoid body (MNTB) convey precise, faithful inhibition vital for binaural hearing and gap detection. The MNTB's structure and function appear evolutionarily well conserved. We compared the cellular physiology of MNTB neurons in bat and gerbil. Because of their adaptations to echolocation or low frequency hearing both species are model systems for hearing research, yet with largely overlapping hearing ranges. We find that bat neurons sustain information transfer with higher ongoing rates and precision based on synaptic and biophysical differences in comparison to gerbils. Thus, even in evolutionarily conserved circuits species-specific adaptations prevail, highlighting the importance for comparative research to differentiate general circuit functions and their specific adaptations.
Cracking the code of cellular protein–protein interactions: Alphafold and whole‐cell crosslinking to the rescue
Authors: Träger Toni , Kastritis Panagiotis L 
Published: March 2023

Integration of experimental and computational methods is crucial to better understanding protein–protein interactions (PPIs), ideally in their cellular context. In their recent work, Rappsilber and colleagues (O'Reilly et al, 2023) identified bacterial PPIs using an array of approaches. They combined whole‐cell crosslinking, co‐fractionation mass spectrometry, and open‐source data mining with artificial intelligence (AI)‐based structure prediction of PPIs in the well‐studied organism Bacillus subtilis. This innovative approach reveals architectural knowledge for in‐cell PPIs that are often lost upon cell lysis, making it applicable to genetically intractable organisms such as pathogenic bacteria.
Characteristics of Fatal Poisonings Among Infants and Young Children in the United States
Authors: Gaw Christopher E. , Curry Allison E. , Osterhoudt Kevin C. , Wood Joanne N. , Corwin Daniel J. 
Published: March 2023

BACKGROUND AND OBJECTIVES
Fatal poisoning is a preventable cause of death among young children. Understanding factors surrounding these deaths will inform future prevention efforts. Our objective was to describe the characteristics of fatal pediatric poisonings using child death review data.

METHODS
We acquired data from 40 states participating in the National Fatality Review-Case Reporting System on deaths attributed to poisonings among children aged ≤5 years from 2005 to 2018. We analyzed select demographic, supervisor, death investigation, and substance-related variables using descriptive statistics.

RESULTS
During the study period, 731 poisoning-related fatalities were reported by child death reviews to the National Fatality Review-Case Reporting System. Over two-fifths (42.1%, 308 of 731) occurred among infants aged &lt;1 year, and most fatalities (65.1%, 444 of 682) occurred in the child’s home. One-sixth of children (97 of 581) had an open child protective services case at time of death. Nearly one-third (32.2%, 203 of 631) of children were supervised by an individual other than the biological parent. Opioids (47.3%, 346 of 731) were the most common substance contributing to death, followed by over-the-counter pain, cold, and allergy medications (14.8%, 108 of 731). Opioids accounted for 24.1% (7 of 29) of the substances contributing to deaths in 2005 compared with 52.2% (24 of 46) in 2018.

CONCLUSIONS
Opioids were the most common substances contributing to fatal poisonings among young children. Over-the-counter medications continue to account for pediatric fatalities even after regulatory changes. These data highlight the importance of tailored prevention measures to further reduce fatal child poisonings.
Neuere Überlegungen zu Hypereides' Rede gegen Demosthenes im Spiegel der Textkritik •
Authors: Horváth László 
Published: March 2023

AbstractThis paper analyses and interprets three passages in Hyperides' speech against Demosthenes and suggests a textual correction. The statements in columns XXIX–XXX become more comprehensible based on the relevant passages in the speech against Diondas. In line 21 of columna XXVIII, αὐτῷ (pronomen personale – Jensen and all the editors) should be replaced by αὑτῷ (pronomen reflexivum), which reconstructs the proper meaning of the text. After Chaeronea it was not the people who were grateful to Demosthenes, but quite the opposite: the people expected that Demosthenes and his companions would be grateful to them. Thus, the name lost in the lacuna is not Lycurgus, but Demosthenes.
Organization of online learning using the intelligent metasystem of open semantic technology for intelligent systems
Authors: Kintonova Aliya , Sabitov Amanbek , Povkhan Igor , Khaimulina Dinara , Gabdreshov Galymzhan 
Published: March 2023

Distance learning today allows you to create a system of mass continuous self-learning, universal exchange of information, regardless of the presence of time and space zones. For more effective online learning, it is necessary to introduce artificial intelligence technologies and methods for implementing learning systems.
In this paper, the objects of research were:
1) the capabilities of the OSTIS open semantic technology, the capabilities of the IMS.OSTIS metasystem for organizing online learning;
2) machine learning method – classification.
Results of the study:
1) an online course was organized using the IMS.OSTIS metasystem of the OSTIS open semantic technology;
2) for the analysis and visualization of training data, a machine learning method is implemented – classification.
The results of the implementation of the online course were obtained using the semantic technology for designing an intelligent learning system: the IMS.OSTIS metasystem using the graphical semantic code SCg. The OSTIS kernel requires a machine with the Ubuntu operating system installed, which is a GNU/Linux distribution based on Debian GNU/Linux, an operating system based on the Linux kernel.
The paper also shows an example of using the machine learning method – classification. This method allows you to classify data. Intelligent processing and visualization of data were carried out based on the results of testing students in order to classify them into letter categories A, B, C, D according to a set of features: scores and points of the average score. The high-level Python library Pandas was used, this is a library for data analysis. To visualize the results of data processing, the Matplotlib library in Python was used
Improvement of the manufacturing method of multi-component paste-like vegetable semi-finished products with a high degree of readiness
Authors: Rudska Nina , Cherevko Oleksander , Pugach Andrii , Ponomarenko Nataliia , Tesliuk Hennadii , Zakharchenko Ruslan , Postadzhiev Alexander , Tytarenko Nataliia 
Published: March 2023

The object of the study is a multi-component past-like semi-finished product based on apples, Jerusalem artichokes, cranberries and hawthorn, which are natural nutrients with original properties obtained by cooking at 55–60 °C in an experimental vacuum-evaporator.
The method of production of a multi-component semi-finished product has been improved by keeping hawthorn in a 10...15 % NaCl solution with the addition of 1 % citric acid at 20...25 °C for 30...45 minutes. Blanching with hot steam at a temperature of 105...110 °C is carried out for: apple (2...3 min), Jerusalem artichoke (5...8 min) and hawthorn (4...6 min), and cranberries are blanched with water for 1.5...3 min at temperatures of 80...90 °C. Wiping the components followed by recipe-component blending and boiling at 55...60 °C in an experimental vacuum-evaporator.
According to the organoleptic parameters, the puree blend containing: apple – 35 %, Jerusalem artichoke – 30 %, cranberry – 25 % and hawthorn – 10 % with a yellow-orange color has the advantage. The ultimate shear stress (pureed components, Pa) is: apple – 14, Jerusalem artichoke – 322, cranberry – 75, hawthorn – 445. The boiled paste mixture has an increased viscosity by 3.5 times compared to the control.
The heating of the working chamber and the stirrer of the vacuum-evaporating apparatus is carried out by a film resistive electronic heater of the radiating type, providing stabilization of the temperature effect and a 45 % increase in the boiling efficiency compared to the classic vacuum apparatus. The improved method will expand the range of competitive semi-finished products of a wide range of applications with natural nutrients and regulated rheological and functional properties, which will contribute to the production of food products with an immunomodulating effect
Determining patterns in the influence of the geometrical parameters of the connecting pipeline on the dynamic parameters of the pneumatic spring of railroad rolling stock
Authors: Kuzyshyn Andrii , Kovalchuk Vitalii , Stankevych Volodymyr , Hilevych Volodymyr 
Published: March 2023

The object of this study is the process of determining the dynamic indicators of the pneumatic spring, which is used as the main element of the second stage of spring suspension in the high-speed rolling stock of the railroad, based on the influence of the geometric parameters of the connecting pipeline.
It has been established that the dynamic indicators of rolling stock mainly depend on the operation of the pneumatic spring, the characteristics of which are largely determined by the geometric parameters of the connecting element between the pneumatic spring and the additional tank.
A mathematical model of oscillations of a dual-mass system has been constructed, the elements of which are connected through a pneumatic spring suspension system. The operation of the pneumatic system is described using the Boyle–Mariotte equations, the state of the ideal gas, the energy for the flow in the connecting pipeline, and the law of conservation of energy.
Theoretical studies into the influence of the diameter and length of the connecting element of the pneumatic spring suspension system on energy loss and damping coefficient for the cycle of its operation and the rigidity of the pneumatic spring have been carried out.
It was established that the dependence of the stiffness of the pneumatic spring, while changing the value of the diameter of the connecting element from 6 mm to 30 mm, is nonlinear.
In the process of compression, the rigidity of the pneumatic spring changes with the length of the connecting element of 1 m from 927 kN/m, static rigidity, to 497 kN/m, dynamic rigidity.
The dependences of energy loss and damping coefficient for the operation cycle of the pneumatic spring suspension system based on the hysteresis loop have been constructed.
It was found that the difference between the damping coefficient in the process of compression and expansion of the pneumatic spring is no more than 4 %.
It was established that the design of high-speed rolling stock is impossible without high-quality modeling of the process of operation of the pneumatic spring suspension system
METHOD OF SELF-DEFENSE OF GROUND (SURFACE) OBJECTS FROM HIGH-PRECISION RADAR MEANS OF AIR SURVEILLANCE
Authors: Zubkov A. M. , Kosovtsov Y. M. , Shcherba A. A. , Petliuk I. V. , Yunda V. A. 
Published: March 2023

Context it is caused by the need to search for scientific and technical ways to ensure the effectiveness of protecting ground (surface) objects from high-precision guided missile weapons.
Objective it is a necessity to ensure effective self-defense of objects from radar homing means.
Method. Electrodynamic modeling of Echo signals from spatially distributed objects, taking into account the features of their design and related operational limitations.
Results. Based on the analysis of the shortcomings of the well-known method of protecting stationary objects from radar surveillance and damage, based on the simulation of an effective reflection center outside the physical dimensions of the object, a new method of countering high-precision measurement of coordinates of stationary and mobile ground (surface) objects is proposed. The technique is based on the spatial deformation of the location of the effective target reflection center with dynamics that exceed the inertial capabilities of the auto-observation contour of the attacking missile (projectile). A structural and functional scheme of technical implementation of the methodology based on the first proposed relationship of simple design and technological solutions is proposed and justified.
Conclusions. The analytical model of Echo signals of spatially distributed ground (surface) objects was further developed, which takes into account the specifics of their design, and on its basis, for the first time, a universal method of self-defense of objects from radar home-leading devices was developed, which is implemented in a patented method and complex to exclude damage to protected objects.
Mucormycosis—A significant hazard in the COVID-19 pandemic?
Authors: Pranave P  , Kshirsagar Rajesh , Sardeshmukh Amruta , Sinha Rinisha , Kumar Gaurav , Kedia Daksh 
Published: March 2023

Mucormycosis was the third most common angio-invasive fungal infection after candidiasis and aspergillosis. However, the frequency of this disease seems to be increasing with the arrival of COVID-19 infection. Despite efforts to better understand the pathophysiology of mucormycosis, its fatality rate remains high. Therefore, this review article aims to accomplish an evidence-based review answering whether mucormycosis is a significant hazard in the era of COVID-19 infection. It contains a wealth of information about the infection's aggressive and deadly characteristics in diabetic and immunocompromised individuals, as well as its pathogenesis, clinical aspects, and management, along with its link to COVID-19, which is the need of the hour.The method used to assemble all the information was a review of the literature, along with multiple case reports supporting the occurrence of COVID-19 linked mucormycosis. This article concludes that uncontrolled diabetes mellitus in COVID-19 patients makes them more vulnerable to secondary infections, primarily mucormycosis, due to the over-zealous use of corticosteroids for its treatment, resulting in immunosuppression. The diagnosis and treatment of this black fungus have also been established to be quite challenging. The effective management of mucormycosis in immunocompromised individuals is centered on a multimodal approach that includes early diagnosis, or cessation of the primary prompting factors, administration of antifungal agents at ideal doses, and comprehensive amputation of all devitalized tissues, along with several adjunctive remedies.