bluuebunny/crossref_metadata_2025_split huggingface dataset:
The sensory effects of light on the electric organ discharge rate of Gymnotus omarorum
Authors: Camargo Ana S. , Caputi Angel A. , Aguilera Pedro A. 
Published: July 2023

ABSTRACT
Gymnotiformes are nocturnal fishes inhabiting the root mats of floating plants. They use their electric organ discharge (EOD) to explore the environment and to communicate. Here, we show and describe tonic and phasic sensory-electromotor responses to light distinct from indirect effects depending on the light-induced endogenous circadian rhythm. In the dark, principally during the night, inter-EOD interval histograms are bimodal: the main peak corresponds to the basal rate and a secondary peak corresponds to high-frequency bouts. Light causes a twofold tonic but opposing effect on the EOD histogram: (i) decreasing the main mode and (ii) blocking the high-frequency bouts and consequently increasing the main peak at the expense of removal of the secondary one. Additionally, light evokes phasic responses whose amplitude increases with intensity but whose slow time course and poor adaptation differentiate from the so-called novelty responses evoked by abrupt changes in sensory stimuli of other modalities. We confirmed that Gymnotus omarorum tends to escape from light, suggesting that these phasic responses are probably part of a global ‘light-avoidance response’. We interpret the data within an ecological context. Fish rest under the shade of aquatic plants during the day and light spots due to the sun's relative movement alert the fish to hide in shady zones to avoid macroptic predators and facilitate tracking the movement of floating plant islands by wind and/or water currents.
Effect of family-centered care interventions on well-being of caregivers of children with cerebral palsy: a systematic review
Authors: Poojari Deepalaxmi Paresh , Umakanth Shashikiran , Maiya G. Arun , Rao Bhamini Krishna , Khurana Sonia , Kumaran D Senthil , Attal Radhika , Brien Marie 
Published: July 2023

Background: Caring for a child with long-term functional limitations can have a negative impact on the physical and psychological well-being of the caregiver. Family-centered care (FCC) interventions have the potential to empower caregivers and contribute to their well-being. This systematic review aimed to synthesize existing evidence on the effectiveness of FCC interventions in improving the well-being of caregivers of children with cerebral palsy (CP), and identify the key components of such interventions that are most commonly practiced and deemed effective. Methods: This review systematically searched seven databases for randomized controlled trials that evaluated the effectiveness of any FCC intervention on the well-being of caregivers of children with or at risk of CP. We used the Cochrane RoB 2.0 tool to assess risk of bias and Critical Appraisal Skills Programme (CASP) checklist for critical appraisal. Due to high heterogeneity of studies, narrative synthesis was used to summarize the data. Results: The review consists of 11 studies which were categorized into five sections based on the components of FCC intervention provided in each individual study: 1. Information provision, and Enabling and partnership (n= 5); 2. Information provision, and Respectful and supportive care (n= 1); 3. Enabling and partnership (n= 2); 4. Enabling and partnership, and Respectful and supportive care (n= 2); 5. Information provision, Enabling and partnership and Respectful and supportive care (n= 1). Risk of bias was low in four studies, unclear in two studies, and high in five studies. Conclusion: FCC interventions were found to be effective in improving caregivers’ satisfaction with attainment of child and caregiver goals. Evidence from multiple studies does not strongly support the effectiveness of FCC interventions on caregiver’s mental health, parenting and personal outcomes. Limited evidence precludes a conclusion on the effectiveness of the components of FCC on well-being of caregivers of children with CP.
Immunological changes in a cohort of COVID-19 survivors: Mansoura University experience
Authors: Elhadidy Tamer , Abdelwahab Heba Wagih , Shahin Doaa , Hewidy Asem , Khashaba Eman , Elmorsey Rehab Ahmad , Abo El Kheir Nermin , Eid Elsayed A. , El-Mesery Ahmed , Elmaria Marwa O. 
Published: July 2023

Background: COVID-19 is a global pandemic that has affected millions of people all over the world since 2019. Infection with COVID-19 initiates a humoral immune response that produces antibodies against specific viral antigens, which in turn is supposed to provide immunity against reinfection for a period of time. The aim of this research was to study the kinetics of IgM and IgG antibodies against SARS-CoV-2. Methods: One hundred and seventeen post-COVID-19 participants were enrolled in the study. Qualitative assessment of IgM and IgG antibodies over six months (three visits) post recovery was conducted. Results: The current study revealed a significant reduction in IgM and IgG titers between the first and second visits (p <0.001). After six months, the antibody titer had declined by 78.8% from the first visit for IgM and by 49.2% for IgG antibodies. Regarding younger age and male sex, statistically significant persistence of IgM antibodies was noticed at the six months follow up. Also, statistically significant persistent IgG immunity was found in male patients and diabetics by the end of the six months follow up. Conclusions: We observed a significant waning of IgM and IgG titers over a period of six months follow up.. The persistence of positive IgM and IgG antibodies by the end of six months was variable due to differences in age, gender and presence of diabetes mellitus.
Super-broadband terahertz absorber: an optimized and magnetized graphene-embedded 1D disordered photonic system
Authors: Mahesh Pulimi , Panigrahy Damodar , Nayak Chittaranjan 
Published: July 2023

In this study, a broadband terahertz absorber was designed and numerically demonstrated. The optical features were computed using 4×4 transfer matrix formalism. The broadband absorption is attained by optimizing the Fermi levels of graphene, the magnetic field, and the thickness of the dielectric layers using the differential evolution algorithm. The results demonstrated that the WMF-optimized scenario offered greater than 90% absorption over a bandwidth of 4.18 THz, and the WoMF&SL scenario provided the shortest bandwidth of 0.89 THz. These findings reveal the significance of the spacer layer to achieve broad absorption. Moreover, the absorption band is tailored to the required spectral range by careful choice of the structural and electrical parameters of the spacer layer; changing the refractive index to 1.2 offers a bandwidth of 4.42 THz and altering the thickness to 12 µm provides a bandwidth of 5.5 THz. The broadband absorption was attained due to the impedance matching provided by the optimized structure over a wide spectral range. Furthermore, the average absorption and bandwidth were enhanced, while fluctuations in the selected absorption band were minimized by engineering the magnetic biasing. The reported super-broadband absorber offers numerous applications in terahertz imaging, terahertz communications, and photodetectors.
Value of a catch-up HPV test in women aged 65 and above: A Danish population-based nonrandomized intervention study
Authors: Tranberg Mette , Petersen Lone Kjeld , Hammer Anne , Elfström Miriam , Blaakær Jan , Jørgensen Susanne Fogh , Bennetsen Mary Holten , Jensen Jørgen Skov , Andersen Berit 
Published: July 2023

Background
High-risk human papillomavirus (HPV) test is replacing cytology as the primary cervical cancer screening test due to superior sensitivity, but in most countries women ≥65 years have never had an HPV test despite they account for around 50% of cervical cancer deaths. We explored the effect of a catch-up HPV test among 65- to 69-year-old women without previous record of HPV-based screening.

Methods and findings
This population-based nonrandomized intervention study (quasi-experimental design) included Danish women aged 65 to 69 with no record of cervical cancer screening in the last ≥5.5 years and no HPV-exit test at age 60 to 64 at the time of study inclusion. Eligible women residing in the Central Denmark Region were invited for HPV screening either by attending clinician-based sampling or requesting a vaginal self-sampling kit (intervention group, n = 11,192). Women residing in the remaining four Danish regions received standard care which was the opportunity to have a cervical cytology collected for whatever reason (reference group, n = 33,387). Main outcome measures were detection of cervical intraepithelial neoplasia (CIN) grade 2 or worse (CIN2+) per 1,000 women eligible for the screening offer and the benefit–harm ratio of the intervention and standard practice measured as the number of colposcopies needed to detect one CIN2+ case. The minimum follow-up time was 13 months for all tested women (range: 13 to 25 months). In the intervention group, 6,965 (62.2%) were screened within 12 months from the date of study inclusion and 743 (2.2%) women had a cervical cytology collected in the reference group. The CIN2+ detection was significantly higher in the intervention group (3.9, 95% confidence interval (CI): [2.9, 5.3]; p < 0.001; n = 44/11,192) as compared to the reference group (0.3, 95% CI: [0.2, 0.6]; n = 11/33,387). For the benefit–harm ratio, 11.6 (95% CI: [8.5, 15.8]; p = 0.69; n = 511/44) colposcopies were performed to detect one CIN2+ in the intervention group as compared to 10.1 (95% CI: [5.4, 18.8]; n = 111/11) colposcopies in the reference group. The study design entails a risk of confounding due to the lack of randomization.

Conclusions
The higher CIN2+ detection per 1,000 eligible women in the intervention group supports that a catch-up HPV test could potentially improve cervical cancer prevention in older women. This study informs the current scientific debate as to whether women aged 65 and above should be offered a catch-up HPV test if they never had an HPV test.

Trial registration
ClinicalTrials.gov NCT04114968.
Initial presentation of early rheumatoid arthritis
Authors: Weman Lauri , Salo Henri , Kuusalo Laura , Huhtakangas Johanna , Kärki Johanna , Vähäsalo Paula , Backström Maria , Sokka-Isler Tuulikki 
Published: July 2023

ObjectivesTo study the joint distribution and clinical picture of rheumatoid arthritis (RA) at the initial presentation in seropositive (anti-citrullinated protein antibody (ACPA) and/or rheumatoid factor (RF) positive) and negative patients and the effect of duration of symptoms on the clinical picture.MethodsData of patients who received reimbursement for DMARDs for newly diagnosed RA in 1/2019 to 9/2021 were extracted from the national databases. Joint counts, presence of symmetrical swelling, other disease activity measures, and patient reported outcomes (PROs) were compared in seropositive and negative patients. Regression analyses were applied to compare clinical variables in patients with duration of symptoms of <3, 3–6, and >6 months, adjusted for age, sex, and seropositivity.ResultsData of 1816 ACPA and RF-tested patients were included. Symmetrical swelling was present in 75% of patients. Seronegativeversuspositive patients had higher value for all disease activity measures and PROs including median swollen joint count (SJC46 10versus5) and DAS28 (4.7versus3.7), (p<0.001). Patients diagnosed in <3 months had higher median pain VAS (62versus52 and 50, p<0.001) and HAQ (1.1versus0.9 and 0.75, p = 0.002) compared to those with a duration of symptoms of 3–6 and >6 months. Patients diagnosed >6 months were ACPA-positive more frequently (77%versus70% in other groups, p = 0.045).ConclusionIncident RA presents mainly as symmetric arthritis. Seronegative patients have higher disease burden at the initial presentation. Patients experiencing more severe pain and decreased functional ability are diagnosed earlier, regardless of ACPA- status.
Predictors of diarrhea among children under 24 months in Nepal: A multilevel analysis of multiple indicator cluster survey 2019
Authors: Thapa Bipin , Sapkota Suman , Hu Yifei 
Published: July 2023

Background
Diarrhea has remained an unmet challenge in global child health. Its severity may be worse than reported in resource-limited settings. Understanding changing epidemiology is critical to combat diarrheal morbidity. Therefore, this study aimed to understand factors associated with diarrhea among under two years children in Nepal.

Methods
A total of 2,348 samples from Multiple Indicator Cluster Survey 2019 were used to estimate the significant child, maternal, household and external environmental predictors of diarrhea using multilevel analysis.

Results
The prevalence of diarrhea was 11.9% (95% CI: 10.2%-13.6%). Children residing in Koshi Province [AOR (Adjusted Odds Ratio): 2.23, 95% CI: 1.22–4.08], Karnali Province (AOR: 2.28, 95% CI: 1.11–4.70), and Sudurpaschim Province (AOR: 4.49, 95% CI: 2.39–8.42) were at higher risk of diarrhea. Children aged 7–23 months (AOR: 1.56, 95% CI: 1.10–2.20), children with ARI symptoms (AOR: 4.14, 95% CI: 2.21–7.72) and children whose mothers had no access to prenatal care (AOR: 1.87, 95% CI: 1.01–3.45) had a higher risk of diarrhea. Children from below the richest household wealth group (AOR: 1.76, 95% CI: 1.01–3.08) and those from households practicing open defecation, with unimproved or limited sanitation facilities (AOR: 1.52, 95% CI: 1.09–2.11) were more likely to have diarrhea.

Conclusion
The findings underscore the need for public health policy-makers to improve sanitation facilities, especially focusing on poor households from Karnali and Sudurpaschim Provinces practicing open defecation to protect the children from the life risk of diarrhea in Nepal.
Physician experiences with and perceptions of risk evaluation and mitigation strategy programs with elements to assure safe use
Authors: Sarpatwari Ameet , Brown Beatrice L. , McGraw Sarah A. , Dejene Sara Z. , Abdurrob Abdurrahman , Kesselheim Aaron S. 
Published: July 2023

Purpose
The US Food and Drug Administration (FDA) Amendments Act of 2007 authorized the FDA to require risk evaluation and mitigation strategy (REMS) programs for drugs with important safety concerns. REMS can have elements to assure safe use (ETASU), such as patient registries, dispensing restrictions, and physician training and certification requirements. We aimed to understand physician experiences with and perceptions of a selection of ETASU REMS.

Methods
Physicians prescribing 1 of 4 ETASU REMS-covered drugs: natalizumab, riociguat, sodium oxybate, and vigabatrin.

Study design
Descriptive phenomenological study based on semi-structured phone interviews.

Data collection/Extraction methods
Qualitative content analysis to summarize physician responses to open-ended questions.

Results
Of 31 physicians (14 female), 6 prescribed riociguat, 6 vigabatrin, 7 sodium oxybate, and 12 natalizumab (5 for Crohn’s disease, 7 for multiple sclerosis), most demonstrated good understanding of the rationale for and requirements of the ETASU REMS but believed that the programs had limited effect on clinical practice. Some physicians reported that the ETASU REMS made them more comfortable with prescribing covered drugs due to heightened oversight, facilitated discussions about treatment, and were likely more beneficial for non-specialists. Concerns were raised about the administrative effort needed to comply with the programs and the potential misuse of patient health information transmitted to manufacturers.

Conclusions
Physicians are generally aware of ETASU REMS and get reassurance from the additional oversight, but the programs can be better integrated into clinical workflows and can be designed to better protect patient health information.
Diagnostic test accuracy of ultrasound for orbital cellulitis: A systematic review
Authors: Anwar Mohammed Rashidul , Mahant Sanjay , Agbaje-Ojo Toni , Mahood Quenby , Borkhoff Cornelia M. , Parkin Patricia C. , Gill Peter J. 
Published: July 2023

Background
Periorbital and orbital cellulitis are inflammatory conditions of the eye that can be difficult to distinguish using clinical examination alone. Computer tomography (CT) scans are often used to differentiate these two infections and to evaluate for complications. Orbital ultrasound (US) could be used as a diagnostic tool to supplement or replace CT scans as the main diagnostic modality. No prior systematic review has evaluated the diagnostic test accuracy (DTA) of ultrasound compared to cross-sectional imaging.

Objective
To conduct a systematic review of studies evaluating the DTA of orbital ultrasound compared with cross-sectional imaging, to diagnose orbital cellulitis.

Methods
MEDLINE, EMBASE, CENTRAL, and Web of Science were searched from inception to August 10, 2022. All study types were included that enrolled patients of any age with suspected or diagnosed orbital cellulitis who underwent ultrasound and a diagnostic reference standard (i.e., CT or magnetic resonance imaging [MRI]). Two authors screened titles/abstracts for inclusion, extracted data, and assessed the risk of bias.

Results
Of the 3548 studies identified, 20 were included: 3 cohort studies and 17 case reports/series. None of the cohort studies directly compared the diagnostic accuracy of ultrasound with CT or MRI, and all had high risk of bias. Among the 46 participants, diagnostic findings were interpretable in 18 (39%) cases which reported 100% accuracy. We were unable to calculate sensitivity and specificity due to limited data. In the descriptive analysis of the case reports, ultrasound was able to diagnose orbital cellulitis in most (n = 21/23) cases.

Conclusion
Few studies have evaluated the diagnostic accuracy of orbital ultrasound for orbital cellulitis. The limited evidence based on low quality studies suggests that ultrasound may provide helpful diagnostic information to differentiate orbital inflammation. Future research should focus studies to determine the accuracy of orbital US and potentially reduce unnecessary exposure to radiation.
Development and initial pilot validation of a treatment fidelity instrument for family-based interoceptive exposure for adolescents with low-weight eating disorders
Authors: Peyser Deena , Costello Kayla , Sysko Robyn , Schulz Kurt , Hildebrandt Tom 
Published: July 2023

Background
This pilot study outlines the development and psychometric evaluation of a therapist adherence coding measure for a novel treatment, Family-Based Treatment Interoceptive Exposure (FBT-IE).

Methods
The IE Adherence Coding Framework (IE-ACF) was developed from the FBT-IE Manual using an iterative process. Items on the IE-ACF were coded by two independent coders as either present or absent with therapists considered adherent if both independent coders coded the item as “present.” Videotaped sessions of FBT-IE of 30 adolescents with low-weight eating disorders (DSM-5 typical/atypical anorexia nervosa) and their families were coded. Participants received the FBT-IE intervention as part of a randomized controlled trial.

Results
Seventy FBT-IE videos were coded. The IE-ACF identified a mean (SD) rating of 80% (±5%) therapist adherence to the protocol across the six-session treatment, with a per item adherence ranging from 36–100%. Two independent coders demonstrated moderate to almost perfect inter-rater reliability (κ range 0.78–0.96) across the sessions.

Conclusion
IE-ACF measured therapist adherence to our novel FBT-IE treatment for adolescents with low-weight eating disorders. Through this study, we demonstrated that 1) our therapists were adherent to the FBT-IE manual in the context of an ongoing clinical trial and 2) that independent coders reliably coded sessions using our novel IE-ACF.
Hepatitis C (HCV) among Black and Latino sexual minority men (SMM) in the Southern United States: Protocol of a prospective cohort epidemiological study
Authors: Ogunbajo Adedotun , Brooks Mitchell , Oke Temitope , Martinez Omar , Latkin Carl , Myers Kirk , Hickson DeMarc A. 
Published: July 2023

Background
Sexual minority men (SMM) who engage in condomless anal sex and injection drug use are at increased risk for viral Hepatitis C (HCV) infection. Additionally, studies have found racial disparities in HCV cases across the United States. However, very few epidemiological studies have examined factors associated with HCV infection in HIV-negative Black and Latino SMM. This paper describes the rationale, design, and methodology of a prospective epidemiological study to quantify the HCV prevalence and incidence and investigate the individual and environmental-level predictors of HCV infection among HIV-negative, Black and Latino SMM in the Southern U.S.

Methods
Beginning in September 2021, 400 Black and Latino SMM, aged 18 years and above, will be identified, recruited and retained over 12-months of follow-up from two study sites: greater Washington, DC and Dallas, TX areas. After written informed consent, participants will undergo integrated HIV/STI testing, including HCV, HIV, syphilis, gonorrhea, and chlamydia. Subsequently, participants will complete a quantitative survey—including a social and sexual network inventory—and an exit interview to review test results and confirm participants’ contact information. Individual, interpersonal, and environmental factors will be assessed at baseline and follow-up visits (6 and 12 months). The primary outcomes are HCV prevalence and incidence. Secondary outcomes are sexual behavior, substance use, and psychosocial health.

Results
To date (March 2023) a total of 162 participants have completed baseline visits at the DC study site and 161 participants have completed baseline visits at the Texas study site.

Conclusion
This study has several implications that will directly affect the health and wellness of Black and Latino SMM. Specifically, our results will inform more-focused HCV clinical guidelines (i.e., effective strategies for HCV screening among Black/Latino SMM), intervention development and other prevention and treatment activities and development of patient assistance programs for the treatment of HCV among uninsured persons, especially in Deep South, that have yet to expand Medicaid.
Asian Cinema and the Use of Space: Interdisciplinary Perspectives, Lilian Chee and Edna Lim (eds) (2018)
Authors: Chow Pei-Sze 
Published: July 2023

Review of: Asian Cinema and the Use of Space: Interdisciplinary Perspectives, Lilian Chee and Edna Lim (eds) (2018)
New York and London: Routledge, 268 pp.,
ISBN 978-1-13854-904-3, p/bk, £42.99
Long Washout Periods Between Biologics for Inflammatory Bowel Disease Clinical Trials Are Unnecessary: A Canadian Retrospective Cohort Study
Authors: Vuyyuru Sudheer K. , Archer Meagan , Nguyen Tran M. , Beaton Melanie , Jairath Vipul 
Published: July 2023

INTRODUCTION:
To assess the safety of early vs late biologic switch in patients with inflammatory bowel disease.

METHODS:
In this retrospective study, we included patients with inflammatory bowel disease who underwent biologic switch between January 2014 and July 2022 at a tertiary center. The primary outcome was any infection by 6 months.

RESULTS:
There was no statistically significant difference between patients who had early biologic switch (≤30 days, n = 51) and late switch (>30 days, n = 77) in either infectious or noninfectious adverse events by 6 and 12 months.

DISCUSSION:
Early biologic switch is safe. A prolonged washout period between 2 biologics is unnecessary.