bluuebunny/crossref_metadata_2025_split huggingface dataset:
Physioland: a motivational complement of physical therapy for patients with neurological diseases
Authors: Martins Tiago , Carvalho Vítor , Soares Filomena , Leão Celina 
Published: June 2023

AbstractThe number of patients with mobility constraints is increasing as a result of neurological diseases. From the substantiation of the lost functions recoveries, it was possible to determine that the nervous system is able to reorganize itself expressing its property called neuroplasticity. Physical therapy is the well-known way to encourage and promote this ability. However, repetitive traditional physical therapy exercises may become boring and patients eventually abandon their physiotherapeutic programs. The development of new environments that motivate patients to continue with their treatments may be a suitable alternative or complementary tool. Serious games seems to be the ideal tool to provide them. Thus, the purpose of this paper is to present Physioland, a serious game already developed which can be a motivational complement for the physical therapy of patients with neurological diseases. Physioland is a non-invasive system that uses Image Processing Techniques and Artificial Intelligence to monitor patients and adapts some exercises of traditional physical therapy to electronic game situations. To determine whether Physioland would be motivating and challenging enough to increase a patient's desire to perform the exercises and continue/complete the rehabilitation process the game was tested in a clinical environment using two samples: one with twelve health professionals in the area of physiotherapy and the other with eleven patients with neurological diseases. The research team carried out a questionnaire-based survey. This questionnaire is an adaptation of another one already validated in the literature—the Technology Acceptance Model (TAM). For the analysis of the data obtained with the Likert scale, percentages were calculated. The answers to the open questions were subject to a content analysis. The results showed that the developed game, Physioland, proved to be highly motivating for patients at the physiotherapy clinic where it was tested. If the results are similar in other clinics, Physioland, can be used as a good and effective complement to traditional physical therapy for patients with neurological diseases.
Root litter quality drives the dynamic of native mineral-associated organic carbon in a temperate agricultural soil
Authors: Poeplau Christopher , Begill Neha , Liang Zhi , Schiedung Marcus 
Published: June 2023

Abstract
Background and aims
Understanding the fate and residence time of organic matter added to soils, and its effect on native soil organic carbon (SOC) mineralisation is key for developing efficient SOC sequestration strategies. Here, the effect of litter quality, particularly the carbon-to-nitrogen (C:N) ratio, on the dynamics of particulate (POC) and mineral-associated organic carbon (MAOC) were studied.

Methods
In a two-year incubation experiment, root litter samples of the C4-grass Miscanthus with four different C:N ratios ranging from 50 to 124 were added to a loamy agricultural topsoil. In an additional treatment, ammonium nitrate was added to the C:N 124 litter to match the C:N 50 litter input ratio. Soils were size-fractionated after 6, 12 and 24 months and δ13C was measured to determine the proportion of new and native POC and MAOC. Litter quality was further assessed by mid-infrared spectroscopy and compound peak analysis.

Results
Litter quality strongly affected SOC dynamics, with total SOC losses of 42.5 ± 3.0% in the C:N 50 treatment and 48.9 ± 3.0% in the C:N 124 treatment after 24 months. Largest treatment effects occurred in mineralisation of native MAOC, which was strongly primed by litter addition. The N amendment in the C:N 124 treatment did not alleviate this potential N mining flux.

Conclusion
Litter quality plays a major role in overall SOC dynamics, and priming for N mining from the MAOC pool could be a dominant mechanism. However, adding N did not compensate for poor litter quality, highlighting the role of litter quality beyond stoichiometric imbalances.
The role of passion diversity, compassion, and self-compassion for team entrepreneurial passion
Authors: Ginting-Szczesny Bernadetta A. , Kibler Ewald , Cardon Melissa S. , Kautonen Teemu , Hakala Henri 
Published: June 2023

Abstract
Passion among entrepreneurial teams can contribute to team performance; yet we still have little understanding of the determinants of team passion. Drawing from the literature on social emotions, we theorize and empirically examine the influence of compassion and self-compassion of team members on the shared team entrepreneurial passion (TEP). Using an original sample of 326 individuals from 107 venture teams, we provide novel evidence that, in addition to team passion diversity, compassion and self-compassion significantly relate to TEP. Specifically, we demonstrate that compassion and self-compassion contribute to polyfocal TEP, which is more beneficial for team outcomes than monofocal TEP.
Riparian and terrestrial grasses display unexpected tolerance to cool-season inundation
Authors: Kitanović Vanja , Greet Joe , McKendrick Scott A. , Jones Christopher S. 
Published: June 2023

AbstractVegetation condition has declined along many regulated river systems globally due to alteration of flow regimes via flow regulation. Understanding how plants respond to inundation is critical for managing regulated river flows to improve riparian vegetation condition. We experimentally tested the effects of inundation duration on the survival and growth of six tufted grass species commonly found in riparian zones in south-eastern Australia. We conducted three nursery-based experiments in late winter/early spring, corresponding with natural temperate flow peaks and managed flows, with inundation treatments on: (1) established plants, up to 35 days inundation; (2) seedlings, up to 25 days inundation; and (3) established plants, up to 53 days inundation including additional shaded treatments. Plant survival, height and biomass growth, and onset of flowering were recorded for established plants, and, for seedlings, survival only. Plant height and biomass growth declined with longer inundation duration across all species, although surprisingly few established plants died. Unexpectedly, grass seedlings were generally tolerant of inundation also, although there was some evidence of increased mortality for the longest treatment (25 days inundation). Shading did not result in increased mortality or reduced height growth of inundated plants. Inundation effects on the onset of flowering were modest and varied between species ranging from earlier to delayed onset. Our results suggest that tufted grasses are tolerant of cool-season inundation. Given that mortality of these species has been observed in the field and experimentally under shorter inundation periods in warmer conditions (late spring and summer), we suggest that seasonal timing of inundation is critical in determining plant responses to inundation.
Multimodality PET and Near-Infrared Fluorescence Intraoperative Imaging of CEA-Positive Colorectal Cancer
Authors: Lwin Thinzar M. , Minnix Megan , Li Lin , Sherman Anakim , Hong Teresa , Wong Jeffery Y. C. , Olafsen Tove , Poku Erasmus , Bouvet Michael , Fong Yuman , Shively John E. , Yazaki Paul J. 
Published: June 2023

Abstract
Purpose

Molecular imaging is a major diagnostic component for cancer management, enabling detection, staging of disease, targeting therapy, and monitoring the therapeutic response. The coordination of multimodality imaging techniques further enhances tumor localization. The development of a single agent for real-time non-invasive targeted positron emission tomography (PET) imaging and fluorescence guided surgery (FGS) will provide the next generation tool in the surgical management of cancer.

Procedures
The humanized anti-CEA M5A-IR800 “sidewinder” (M5A-IR800-SW) antibody-dye conjugate was designed with a NIR 800 nm dye incorporated into a PEGylated linker and conjugated with the metal chelate p-SCN-Bn-deferoxamine (DFO) for zirconium-89 PET imaging (89Zr, half-life 78.4 h). The dual-labeled 89Zr-DFO-M5A-SW-IR800 was evaluated for near infrared (NIR) fluorescence imaging, PET/MRI imaging, terminal tissue biodistribution, and blood clearance in a human colorectal cancer LS174T xenograft mouse model.

Results
The 89Zr-DFO-M5A-SW-IR800 NIR fluorescence imaging showed high tumor targeting with normal liver uptake. Serial PET/MRI imaging was performed at 24 h, 48 h, and 72 h and showed tumor localization visible at 24 h that persisted throughout the experiment. However, the PET scans showed higher activity for the liver than the tumor, compared to the NIR fluorescence imaging. This difference is an important finding as it quantifies the expected difference due to the sensitivity and depth of penetration between the 2 modalities.

Conclusions
This study demonstrates the potential of a pegylated anti-CEA M5A-IR800-Sidewinder for NIR fluorescence/PET/MR multimodality imaging for intraoperative fluorescence guided surgery.
Individual Differences in Mathematical Problem-Solving Skills Among 3- to 5-Year-Old Preschoolers
Authors: Vessonen T. , Hellstrand H. , Aunio P. , Laine A. 
Published: June 2023

AbstractThe aim of this study was to investigate individual differences in mathematical problem-solving among 3- to 5-year-old children (N = 328; n3-year-olds = 115, n4-year-olds = 167, n5-year-olds = 46). First, we examined the extent to which children in this age group were able to solve open and closed non-routine mathematical problems representing a variety of mathematical domains. Second, we investigated the extent to which underlying academic and cognitive skills (i.e., expressive and receptive language, visuospatial, and early numeracy skills) were associated with individual differences in mathematical problem-solving concurrently and longitudinally (i.e., one year later). The results showed that 4- to 5-year-olds were able to solve a variety of non-routine mathematical problems. However, though 3-year-olds were also able to solve a variety of problems, the mathematical problem-solving measure did not meet the reliability criteria, resulting in excluding 3-year-olds from further analyses. Expressive and receptive language, visuospatial, and early numeracy skills were associated with mathematical problem-solving concurrently among 4-year-olds. Among 5-year-olds, only visuospatial and early numeracy skills were associated with mathematical problem-solving. Furthermore, only prior mathematical problem-solving skills and early numeracy skills predicted mathematical problem-solving skills longitudinally. These findings indicate that preschoolers are able to solve open and closed non-routine mathematical problems representing a variety of mathematical domains. Additionally, individual differences may stem not only from differences in mathematical problem-solving skills but also from early numeracy.
New examples of harmonic maps to the hyperbolic plane via Bäcklund transformation
Authors: Polychrou G. , Papageorgiou E. , Fotiadis A. , Daskaloyannis C. 
Published: June 2023

AbstractWe study harmonic maps from a subset of the complex plane to a subset of the hyperbolic plane. In Fotiadis and Daskaloyannis (Nonlinear Anal 214, 112546, 2022), harmonic maps are related to the sinh-Gordon equation and a Bäcklund transformation is introduced, which connects solutions of the sinh-Gordon and sine-Gordon equation. We develop this machinery in order to construct new harmonic maps to the hyperbolic plane.
Data Catalogs in the Enterprise: Applications and Integration
Authors: Jahnke Nils , Otto Boris 
Published: June 2023

AbstractDespite investing heavily in data-related technology and human resources, enterprises are still struggling to derive value from data. To foster data value creation and move toward a data-driven enterprise, adequate data management and data governance practices are fundamental. To support these practices, organizations are building (meta)data management landscapes by combining different tools. Data catalogs are a central part of these landscapes as they enable an overview of available data assets and their characteristics. To deliver their highest value, data catalogs need to be integrated with existing data sources and other data management tools. However, enterprises struggle with data catalog integration because (a) not all data catalog application types foster enterprise-wide data management and data governance alike, and (b) several technical characteristics of data catalog integration remain unclear. These include the supported data sources, data catalog federation, and ways to provision data access. To tackle these challenges, this paper first develops a typology of data catalog applications in the enterprise context. Based on a review of the academic literature and an analysis of data catalog offerings, it identifies four enterprise-internal and three cross-enterprise classes of data catalog applications. Second, an in-depth analysis of 51 data catalog offerings that foster enterprise-wide metadata management examines key characteristics of the technical integration of data catalogs.
Extracellular vesicle microRNA-mediated transcriptional regulation may contribute to dementia with Lewy bodies molecular pathology
Authors: Isik Fatma Busra , Knight Helen Miranda , Rajkumar Anto P. 
Published: June 2023

AbstractObjective:Dementia with Lewy bodies (DLB) is the second most common dementia. Advancing our limited understanding of its molecular pathogenesis is essential for identifying novel biomarkers and therapeutic targets for DLB. DLB is an α-synucleinopathy, and small extracellular vesicles (SEV) from people with DLB can transmit α-synuclein oligomerisation between cells. Post-mortem DLB brains and serum SEV from those with DLB share common miRNA signatures, and their functional implications are uncertain. Hence, we aimed to investigate potential targets of DLB-associated SEV miRNA and to analyse their functional implications.Methods:We identified potential targets of six previously reported differentially expressed miRNA genes in serum SEV of people with DLB (MIR26A1,MIR320C2,MIR320D2,MIR548BA,MIR556, andMIR4722) usingmiRBaseandmiRDBdatabases. We analysed functional implications of these targets usingEnrichRgene set enrichment analysis and analysed their protein interactions usingReactomepathway analysis.Results:These SEV miRNA may regulate 4278 genes that were significantly enriched among the genes involved in neuronal development, cell-to-cell communication, vesicle-mediated transport, apoptosis, regulation of cell cycle, post-translational protein modifications, and autophagy lysosomal pathway, after Benjamini-Hochberg false discovery rate correction at 5%. The miRNA target genes and their protein interactions were significantly associated with several neuropsychiatric disorders and with multiple signal transduction, transcriptional regulation, and cytokine signalling pathways.Conclusion:Our findings providein-silicoevidence that potential targets of DLB-associated SEV miRNAs may contribute to Lewy pathology by transcriptional regulation. Experimental validation of these dysfunctional pathways is warranted and could lead to novel therapeutic avenues for DLB.
The Right and the (Provincial) Welfare State: The Case of the Coalition Avenir Québec Government
Authors: Béland Daniel , Dinan Shannon , Jacques Olivier , Marier Patrik 
Published: June 2023

AbstractIn this article, we study how political parties located on the right of the political spectrum adapt to changing electoral and political constraints. Drawing on the concept of policy feedback, we turn to the politics of social policy in the province of Quebec to show that the Coalition Avenir Québec (CAQ), a right-wing party, embraced a more centrist strategy than the preferences of its electoral base would suggest. The CAQ has rejected the austerity policies associated with the previous government and has favoured social policy expansion rather than tax cuts or a quicker return to balanced budgets. We then explore the reasons for this move toward the centre. Our evidence suggests that self-reinforcing feedback effects from existing policies shape public opinion and electoral strategies, which contribute to moderating the actions of this right-wing governing party.
Granitic magmatism associated with gold mineralization: evidence from the Baizhangzi gold deposit, in the northern North China Craton
Authors: Zhao Zhi-xiong , Xu Wei-jun , Dong Guo-chen , Santosh M , Li Hong-bin , Chang Ze-guang 
Published: June 2023

AbstractThe relationship between magmatism and gold mineralization has been a topic of interest in understanding the formation of ore deposits. The Baizhangzi gold deposit, located in the northern margin of the North China Craton, is hosted by the Baizhangzi granite (BZG) and provides a case to evaluate the relation between granite and gold mineralization in Late Triassic. In this study, we present petrography, bulk geochemistry, zircon U-Pb isotope and trace elements data, as well as major elements of biotite and plagioclase for the BZG to evaluate the petrogenesis and link with gold mineralization. The BZG comprises biotite monzogranite, biotite-bearing monzogranite and monzogranite (BZGs). Zircon U-Pb geochronology shows that all the granitoids of BZGs were coeval with a formation age of 232 Ma. The granitoids, with high SiO2, Al2O3and Sr, while low Y and Yb, show adakitic affinity. They are enriched in LILFs (e.g., Rb, Ba, Th, U and Sr) and LREEs, while depletion in HFSEs (e.g., Nb, Ta, P and Ti). The geochemical and mineral chemical data suggest that the granitoids have experienced the fractional crystallization of biotite + plagioclase + K- feldspar + apatite. Crystallization temperature is estimated as ca. 700°C, and pressure is between 0.71 kbar and 1.60 kbar. The monzogranite shows higher values of logfO2, △FMQ and △NNO than the biotite-bearing monzogranite, ranging from −19.76 to −11.71, −4.93 to +3.67 and −5.48 to +3.11, respectively. The fractional crystallization, together with highfO2, K-metasomatism and low evolution degree, provided favourable conditions for gold mineralization.
Use of pointing in parent-child interactions by hearing children of deaf and hearing parents: A follow-up from 1- to 3-years of age
Authors: KANTO Laura , LAAKSO Minna , HUTTUNEN Kerttu 
Published: June 2023

AbstractPointing plays a significant role in communication and language development. However, in spoken languages pointing has been viewed as a non-verbal gesture, whereas in sign languages, pointing is regarded to represent a linguistic unit of language. This study compared the use of pointing between seven bilingual hearing children of deaf parents (Kids of Deaf Adults [KODAs]) interacting with their deaf parents and five hearing children interacting with their hearing parents. Data were collected in 6-month intervals from the age of 1;0 to 3;0. Pointing frequency among the deaf parents and KODAs was significantly higher than among the hearing parents and their children. In signing dyads pointing frequency remained stable, whereas in spoken dyads it decreased during the follow-up. These findings suggested that pointing is a fundamental element of parent-child interaction, regardless of the language, but is guided by the modality, gestural and linguistic features of the language in question.
Structural complexity reduction in English–French bilingual children’s event encoding
Authors: ENGEMANN Helen 
Published: June 2023

AbstractPrevious research on the L1 acquisition of motion event expression suggests that mapping multiple semantic components onto syntactic units is associated with greater difficulties in verb-framed than in satellite-framed languages, because the former require more complex structures (using subordination). This study investigated the impact of this language-specific difference in English–French bilingual children’s caused motion expressions. 2L1 children (n = 96) between 4 and 10 years and monolingual English and French children (n = 96) described video animations portraying caused motion events involving multiple semantic components. Results revealed reduced rates of subordinate constructions in bilinguals’ French descriptions, and more so in older than younger children, while English responses aligned with monolinguals. Semantic density of responses strongly predicted syntactic complexity, but exclusively in French. These asymmetric findings indicate a task-specific syntactic relief strategy and are discussed in the context of theoretical claims about universal biases of event encoding and bilingual-specific optimisation strategies.
Disruption of the serial position effect as an early marker of Alzheimer’s disease in Spanish–English bilinguals
Authors: Mizrahi Reina , Cromheecke Oona , Salmon David P. , Gollan Tamar H. 
Published: June 2023

AbstractObjectives:The present study examined if disruption of serial position effects in list recall could serve as an early marker of Alzheimer’s disease (AD) in Spanish–English bilinguals.Methods:We tested 20 participants initially diagnosed as cognitively normal or with mild cognitive impairment who declined and eventually received a diagnosis of AD (decliners), and 37 who remained cognitively stable (controls) over at least 2 years. Participants were tested on the Consortium to Establish a Registry for Alzheimer’s Disease (CERAD) Word List Learning Test in English or Spanish as part of an annual neuropsychological evaluation.Results:Compared to controls, decliners exhibited significantly reduced recall including reduced primacy scores (i.e., items recalled from the first three list items on Trial 1), whereas recency scores (i.e., items recalled from the last 3 list items on Trial 1) were equivalent in decliners and controls. Further analyses suggested that the sensitivity of the primacy effect to preclinical AD was initially stronger in participants tested in Spanish, a surprising finding given that the CERAD was developed for English speakers. However, in the subsequent year of testing, primacy scores declined to the same level regardless of language of testing.Conclusions:Several list learning measures may facilitate early diagnosis of AD in Spanish–English bilinguals, possibly including the relatively understudied primacy effect. Additional studies are needed to investigate the possibility that linguistic or demographic variables might modulate sensitivity of list learning tests to preclinical AD, which could lead to broader improvements in their utility for early diagnosis of AD in all populations.
Towards an Effective Appellate Mechanism for ISDS Tribunals
Authors: Kucik Jeffrey , Puig Sergio 
Published: June 2023

AbstractThis Article identifies the problems of an Appellate Mechanism for ISDS Tribunals in relation with its possible benefits. We propose the inclusion of certain design features to improve the working of an eventual Appellate Mechanism and help mitigate problems related to procedural, conflict resolution, and substantive concerns. We finish by identifying the most central problems with a possible Appellate Mechanism, which helps to narrow down options within the ongoing reform process at UNCITRAL. Overall, we illustrate how institutional choice is always contextual and that all institutional options are imperfect and subject to important trade-offs.