bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of the Efficacy of Transient Overvoltages Suppression Measures in Different Wind Farm Topologies
Authors: Eliyan Tamer , Wadie Fady 
Published: March 2023

Abstract
Various overvoltage mitigation schemes were used in literature in suppression of switching overvoltages in wind farms. However, the evaluation of how the effectiveness of these mitigation techniques would vary with the change of the wind farm topology is still un-explored territory. The main aim of this paper is to study the effectiveness of four mitigation schemes namely; R-L smart choke, R-C snubber circuit, surge capacitor and pre-insertion resistor (PIR) were studied in four different wind farm topologies; radial, single-sided ring, double-sided ring and star topologies. The topologies were based on a real wind farm located in Zaafrana, Egypt. The results showed that R-L choke to be the most effective scheme for all topologies followed by PIR, R-C snubber and surge capacitor schemes respectively. Their percentage of reduction of overvoltage ranged from 62–84% for R-L choke, 33–67% for PIR, 8–25% for R-C snubber circuits and 4–15% for surge capacitors. Also, it was shown that the change of the wind farm topology didn’t affect the order of effectiveness of the mitigation schemes such that R-L remained the most effective and surge capacitor the least effective for all topologies.
Spinal Anesthesia in a Healthy Parturient Causing Suspected Bullous Pemphigoid Lesions: A Case Report
Authors: Karam Cynthia , Nafeh Nancy Abou , Kaddoum Roland , Zeeni Carine , Khalili Amro 
Published: March 2023

Abstract
We present a case of suspected bullous pemphigoid lesions after spinal anesthesia in a previously healthy parturient presenting at term for an elective secondary cesarean section. On day 1 post-partum, pruritic red fluid-filled clustered bullae highly resembling those of bullous pemphigoid were noted around the spinal anesthesia injection site. Fusidic acid/betamethasone skin cream was prescribed by a dermatologist for twice-daily application. The bullae decreased in size gradually and became crusted 1 week post-partum with mild residual pruritus. At 6 weeks post-partum, the bullae completely disappeared without a scar. Checking the site of neuraxial blockade on the first day postoperatively allowed early detection of such unique skin lesions.
Predictive factors of early pregnancy loss during in vitro fertilization/ intracytoplasmic sperm injection (IVF/ICSI): retrospective study on 1806 embryo transfers
Authors: Morcel Karine , Merviel Philippe , James Pandora , Bouée Sarah , Guillou Mathilde Le , Pertuisel Diane , Chabaud Jean-Jacques , Roche Sylvie , Perrin Aurore , Drapier Hortense , Beauvillard Damien 
Published: March 2023

AbstractEarly pregnancy loss (EPL) is a spontaneous miscarriage of a clinical pregnancy during the first trimester. Several factors of EPL have been studied but results were discordant. We performed a retrospective study in our ART center, comparing baseline data and IVF/ICSI outcomes between cycles with EPL, ongoing pregnancy and without pregnancy. Ectopic pregnancies and biochemical pregnancies (without visualization of a gestational sac on ultrasound) were excluded. The aim of this study is to compare these different cycles, and analyze the risk factors for EPL. We included 2555 IVF/ICSI cycles leading to 2193 oocyte pick-ups and 1806 embryo transfers. Several characteristics (women’s age, infertility diagnosis and duration, estradiol level on the day of hCG-trigger, endometrial thickness, day of embryo transfer) appeared to be risk factors of EPL in univariate analysis. Only women’s age has a significant (p < 0.001) influence in multivariate analysis on the rate of EPL, with an OR: 1.71 if the woman’s age ≥ 35 years old (reference < 35 y.o = 1), 2.96 if ≥ 38 y.o and 5.31 if ≥ 40 y.o. In this study, we observed an increase in EPL rate by 4.15% per year in women over 35 years of age.
Clinical significance of MATN1-AS1 as ceRNA of Mir-200b in tissues and serum of patients with cervical cancer
Authors: He Lijie , Wang Jing , Zhang Heping 
Published: March 2023

Abstract
Objective:To analyze the clinical significance of MATN1-AS1 as ceRNA of Mir-200b in the tissues and serum of cervical cancer patients.
Methods: A total of 50 patients with cervical cancer admitted to our hospital from March 2018 to March 2019 were selected as the research objects. All patients underwent surgical resection of cancer tissues in our hospital, and cervical cancer tissues and adjacent tissues more than 2cm away from the edge of cancer tissues were retained. Patients with cervical cancer were selected as the research group, and 50 patients with benign uterine lesions were selected as the control group. The expressions of MATN1-AS1 and Mir-200b in cervical cancer tissues and serum were detected by real-time PCR, and the correlation between MATN1-AS1 and Mir-200b was analyzed. The relationship between MATN1-AS1, Mir-200b and clinical features was analyzed, and the 3-year survival rate of cervical cancer patients was analyzed.
Results:Compared with adjacent tissues, the relative expression levels of MATN1-AS1 and Mir-200b in cancer tissues were significantly increased (P<0.05). Compared with the control group, the relative expression levels of MATN1-AS1 and mir-200b in the study group were increased (P<0.05). The expression levels of matn1-as1 and mir-200b were higher in poorly differentiated, tumor ≥4cm, FIGO stage ⅲ-ⅳ, and lymph node metastasis patients (P < 0.05). Correlation analysis showed that MATN1-AS1 was positively correlated with Mir-200b (r=0.625，P=0.001). Compared with blank control group, the relative expression levels of MATN1-AS1 and Mir-200b in MATN1-AS1 silencing group were decreased (P<0.05). The 3-year survival rate of 48 patients with cervical cancer was 66.67% (32/48). The survival rate of patients with high expression of MATN1-AS1 was lower than that of patients with low expression of MATN1-AS1, and the survival rate of patients with high expression of Mir-200b was lower than that of patients with low expression of Mir-200b (x2=4.251, 5.244, P=0.011, 0.008).
Conclusion: There is a potential binding point between MATN1-AS1 and Mir-200b. The expressions of MATN1-AS1 and Mir-200b are increased in the tissues and serum of cervical cancer patients, and they are positively correlated. Silencing of MATN1-AS1 in cervical cancer cell lines can reduce the expression of Mir-200b. Matn1-as1 can regulate the expression of Mir-200b and participate in the occurrence and development of cervical cancer.
Wild mushroom classification based on improvedMobileViT deep learning
Authors: Peng Youju , Xu Yang , Shi Jin , Jiang Shiyi 
Published: March 2023

Abstract
Wild mushrooms are not only tasty but also rich in nutritional value, but it is difficult for non-specialists to distinguish poisonouswild mushrooms accurately. Given the frequent occurrence of wild mushroom poisoning, we propose a new deep learningmethod (M-ViT) combining convolutional neural networks(ConvNets) and attention networks to solve this social problem. First, we introduce an attention mechanism SE module in the MV2 structure of the network to enhance the representation of picture channels. Then, design a multidimensional attention module ( MDA) to guide the network to thoroughly learn and utilize local and global features through short connections. Moreover, used the ASPP module to obtain longer distance relations, fuse the model features from different layers, and use the obtained joint features for wild mushroom classification. We validated on two datasets, mushroom and MO106, and the results showed that M-ViT performed the best on the two test datasets with accurate dimensions of 96.21% and 91.83%, respectively. We compared the performance of our method with that of more advancedConvNets and attention networks (Transformer), and our method achieved good results.
Effects of soda consumption on cardiac tissue in rats submitted to concurrent training.
Authors: Tomiazzi Maria Luisa , Moraes Thiago Pereira , Santos Rafael Felipe Siqueira dos , Valério Luis Felipe , Santos Lucas Silva , Garcia Thiago Alves , Ozaki Guilherme Akio Tamura , Marcelo Henrique Izaias , Filho José Carlos Silva Camargo , Chacon Robson 
Published: March 2023

Abstract

The association of aerobic resistance training (ART) and strength training (ST) is called "concurrent training" (CT), and this type of training can help combat the emergence of cardiovascular diseases. Despite the benefits of ST[U1] , it is known that a good portion of the population consumes soft drinks, which can bring negative consequences for health, especially the heart. The aim of this study was to compare the effects caused in cardiac tissue of animals that consumed soda and performed a CT protocol. Thirty-two male Wistar rats were used, subdivided into four groups: Control (C [n=8]); Soda Consumption (SC [n=8]); Concurrent Training (CT [n=8]); and CT with Soda Consumption (CTSC) [n=8]). The CT was composed of aerobic swimming exercises and resistance exercises through jumps in the aquatic environment. The animals performed 3 training sessions per week for 4 weeks. CT promoted an increase in the area, perimeter, and diameter of cardiomyocytes, while the consumption of soda, both isolated and added to the CT, did not generate alterations in the variables analyzed. CT generated an increase in cardiomyocytes and the consumption of soda caused a decrease in these cells. However, this decrease showed no statistically significant difference.
[U1]Deveria ser ‘CT’?
Verteporfin attenuates cardiac fibrosis after myocardial infarction by suppressing the YAP-Smad2/3 signaling pathway
Authors: Zhang Pei , Liao Ruili , Gan Yang , Liu Hui , Mao Liang , Nie Yongmei , yu Fengxu , Deng Mingbing , LIAO Bing , Fu Yong 
Published: March 2023

Abstract
Purpose
Excessive cardiac fibrosis and remodeling occur after myocardial infarction. Yes-associated protein (YAP) is a major transcriptional co-activator of the Hippo pathway and an important regulator of cardiac fibrosis. Verteporfin is a pharmacological inhibitor of YAP that effectively inhibits fibrosis and inflammatory responses. Therefore, this study aimed to explore the effects of verteporfin on cardiac fibrosis after myocardial infarction (MI) and its possible mechanisms.
Methods
Wild-type C57BL/6J mice were subjected to MI by ligating their left anterior descending coronary artery (LAD) and treating them with verteporfin (50 mg/kg/48 h) or phosphate-buffered saline for 2 weeks. Echocardiography was performed to evaluate cardiac function after 2 weeks, and hematoxylin and eosin and Masson staining were performed to evaluate the degree of myocardial fibrosis and inflammatory response. The protein expression levels of the YAP-Smad2/3 pathway, inflammatory factors, and fibrosis markers in the heart and in vitro were determined using western blotting and immunofluorescence staining.
Results
Compared to the MI group, verteporfin treatment improved cardiac function and fibrosis in mice post-MI. Moreover, myocardial YAP and SMAD2/3 expression were reduced in verteporfin-treated animals. Hematoxylin and eosin staining and molecular examination showed inflammatory factor and cardiac fibrosis marker expression in the heart sections.
Conclusion
Verteporfin can attenuate cardiac fibrosis and inflammatory responses and improve cardiac function by suppressing the YAP-Smad2/3 signaling pathway post-MI.
Tool wear condition monitoring method based on Relevance Vector Machine
Authors: Jia Ruhong , Yue Caixu , Liu Qiang , Xia Wei , Qin Yiyuan , Zhao Mingwei 
Published: March 2023

Abstract
During the machining process, the tool wear state is closely related to the quality of the workpiece, which will directly affect the performance of the equipment. Not timely replacement of tools will lead to increased processing costs, low workpiece surface quality, and even damage to processing equipment. Therefore, research on tool wear monitoring is necessary for the tool processing industry. By analyzing the relationship between tool wear and sensor signals to determine the required acquisition signal. Aiming at the problem that the original sensor data cannot be directly used in the machining process, the signal processing technology is used to preprocess the original signal, remove the invalid signal collected during the cutting process, and use the filtering method to eliminate the singular points in the original signal. The time domain and frequency domain features of the data are extracted. Firstly, the features are optimized by the extreme random tree(ET), and the tool wear is taken as the target vector. The Pearson correlation coefficient(PCC) between the target vector and the filtered features is calculated, and the features with solid correlation with the target vector are selected. The results show that the relevance vector machine(RVM) model proposed in the research can effectively monitor tool wear.
The Impact of Race and Age on Response to Neoadjuvant Therapy and Long-Term Outcomes in Black and White Women with Early-Stage Breast Cancer
Authors: Terman Elizabeth , Sheade Jori , Zhao Fangyuan , Howard Frederick , Jaskowiak Nora , Tseng Jennifer , Chen Nan , Hahn Olwen , Fleming Gini , Huo Dezheng , Nanda Rita 
Published: March 2023

Abstract
Purpose: There are a paucity of data and a pressing need to evaluate response to neoadjuvant chemotherapy (NACT) and determine long-term outcomes in young Black women with early-stage breast cancer (EBC).
Methods: We analyzed data from 2,196 Black and White women with EBC treated at the University of Chicago over the last 2 decades. Patients were divided into groups based on race and age at diagnosis: Black women 40 years, White women 40 years, Black women 55 years, and White women 55 years. Pathological complete response rate (pCR) was analyzed using logistic regression. Overall survival (OS) and disease-free survival (DFS) were analyzed using Cox proportional hazard and piecewise Cox models.
Results: Young Black women had the highest risk of recurrence, which was 22% higher than young White women (p=0.434) and 76% higher than older Black women (p=0.008). These age/racial differences in recurrence rates were not statistically significant after adjusting for subtype, stage, and grade. In terms of OS, older Black women had the worst outcome. In the 397 women receiving NACT, 47.5% of young White women achieved pCR, compared to 26.8% of young Black women (p=0.012).
Conclusions: Black women with EBC had significantly worse outcomes compared to White women in our cohort study. There is an urgent need to understand the disparities in outcomes between Black and White breast cancer patients, particularly in young women where the disparity in outcome is the greatest.
Prevalence of metabolic syndrome and components in rural, semi-urban and urban areas in the Littoral Region in Cameroon: impact of physical activity
Authors: Bilog Nadine Carole , Ndongo Jerson Mekoulou , Lele Elysée Claude Bika , Guessogo Wiliam Richard , Assomo-Ndemba Peguy Brice , Ahmadou . , Babayana Noel Etaga , Mbama Yves Julien , Bindi Josiane Gertrude B.N. , Temfemo Abdou , Mandengue Samuel Honoré , Guyot Jessica , Dupre Caroline , Barth Nathalie , Bongue Bienvenu , Ngoa Laurent Serge Etoundi , Ayina Clarisse Noel Ayina 
Published: March 2023

Abstract
Background
living areas in developing countries impacts seriously lifestyle by the increase the consumption of energy-rich foods, less energy expenditure and sedentary behaviors. Urbanization is also associated with less practice of physical activity (PA) which is considered as the leading cause of metabolic syndrome (MetS) which MetS prevalence vary in African countries. The present study aimed to assess the effect of PA on MetS according to urbanization in the littoral region in Cameroon.
Methods
A cross-sectional study was conducted in three geographical settings (urban, semi-urban, and rural) in the littoral region in Cameroon. A total of 879 participants was included (urban: 372, semi-urban: 195 and rural: 312). The MetS was defined according to the International Federation of Diabetes 2009. The level of PA was assessed using the Global physical activity questionnaire.
Results
Low level of PA was (P < 0.0001) reported in urban (54.5%), semi urban (28.7%) and rural (16.9%) and high in rural area (77.9%). The prevalence of MetS was higher in urban areas (37.2%) follow to the rural (36.8%) and the semi-urban (25.9%). Hyperglycemia (p = 0.0110), low HDL-c (p < 0.0001) and high triglyceridemia (p = 0.0068) were most prevalent in urban residents. Participants with low level of PA were at risk of MetS (OR: 1.751, 95% CI: 1.335–2.731, p = 0.001), hyperglycemia (OR: 1.909, 95% CI: 1.335–2.731, p = 0.0004) abdominal obesity(OR: 2.007, 95% CI : 1.389-2.900, p = 0.0002), low HDL-c (OR: 1.539, 95% CI : 1.088–2.179, p = 0.014) and those with moderate level of PA were protected against high blood pressure(OR : 0.452, 95% CI: 0.298–0.686, p = 0.0002) and compared to those with high level of PA. Urban dwellers had 1.708 great risk of MetS compared to rural residents, urban was also at risk of hyperglycemia (OR: 1.611, 95% CI : 1.170–2.219, p = 0.003) and protected against high blood pressure (OR :0.314, 95% CI :0.212–0.466, p < 0.0001), Abdominal obesity (OR : 0.570, 95% CI : 0.409–0.794, p = 0.0009), and Low HDL-c (OR : 0.725, 95% CI: 0.534–0.983, p = 0.038) compared to rural residents.
Conclusions
MetS was more prevalent in urban dwellers and was associated with a low level of PA.
Effect of polypyrrole on the capacitance enhancement of the spherical ZnS-ZnO/G-C3N4 nanocomposite for supercapacitor applications
Authors: Elsayed Asmaa M. , Alnuwaiser Maha Abdallah , Rabia Mohamed 
Published: March 2023

Abstract
ZnS-ZnO/graphitic carbon nitride (G-C3N4) nanocomposite has been synthesized using the hydrothermal method, in which 0.05 g G-C3N4 is added through the composite formation. Moreover, brain-like shape polypyrrole is prepared using the oxidation polymerization method. The XRD confirms the crystalline nature of these materials, and the SEM and TEM analyses confirm the morphological properties of these materials, in which 2D G-C3N4 nanosheets are formed. ZnS-ZnO/G-C3N4 nanocomposite consists of spherical particles with an average particle size of 15 nm that covers the 2D G-C3N4 sheets. ZnS-ZnO/G-C3N4 nanocomposites without/with polypyrrole are used as a paste for the two-symmetric electrodes hybrid supercapacitor. The charge (0.5 to 1.3 A/g), cyclic voltammetry (0.0 to 1.0 potential window), impedance, and stability for the prepared supercapacitor are studied using electrochemical measurements. ZnS-ZnO/G-C3N4 supercapacitors have specific capacitance (CS) of 15.1 and 152.2 F/g without/with the physical addition of polypyrrole, respectively. Also, they have energy density values of 1.17 and 11.87 W.h.kg− 1, respectively. Also, the capacitance retention values are 88.6 and 90.2% without/with polypyrrole addition till 500 cycles. These values confirm the behavior of the polypyrrole material in the enhancement of the supercapacitor efficiency, storage capacity, and stability.
Common fixed point Theorems for Interpolative Mapping in Bicomplex-valued b-Metric Space with An application to Non-linear matrix Equation
Authors: Wangwe Lucas 
Published: March 2023

Abstract
This manuscript plans to prove a common fixed point theorem for interpolative contraction mapping in Bicomplex-valued b-metric spaces. our results generalize and extend several works in literature. We provide an example for verification of our results. To demonstrate the effectiveness of our main result, we give an application to non-linear matrix equations.
The Genetic and Epigenetic Features of Bilateral Wilms Tumor Predisposition: A Report from the Children's Oncology Group AREN18B5-Q Study
Authors: Murphy Andrew J. , Cheng Changde , Williams Justin , Shaw Timothy I. , Pinto Emilia M. , Dieseldorff-Jones Karissa , Brzezinski Jack , Renfro Lindsay A. , Tornwall Brett , Huff Vicki , Hong Andrew L. , Mullen Elizabeth A. , Crompton Brian , Dome Jeffrey S. , Fernandez Conrad V. , Geller James I. , Ehrlich Peter F. , Mulder Heather , Oak Ninad , Maciezsek Jamie , Jablonowski Carolyn , Fleming Andrew M. , Pichavaram Prahalathan , Morton Christopher L. , Easton John , Nichols Kim E. , Clay Michael R. , Santiago Teresa , Zhang Jinghui , Yang Jun , Zambetti Gerard P. , Wang Zhaoming , Davidoff Andrew M. , Chen Xiang 
Published: March 2023

Abstract
This study comprehensively evaluated the landscape of genetic and epigenetic events that predispose to synchronous bilateral Wilms tumor (BWT). We performed whole exome or whole genome sequencing, total-strand RNA-seq, and DNA methylation analysis using germline and/or tumor samples from 68 patients with BWT from St. Jude Children’s Research Hospital and the Children’s Oncology Group. We found that 25/61 (41%) of patients evaluated harbored pathogenic or likely pathogenic germline variants, with WT1 (14.8%), NYNRIN (6.6%), TRIM28 (5%) and the BRCA-related genes (5%) BRCA1, BRCA2, and PALB2 being most common. Germline WT1 variants were strongly associated with somatic paternal uniparental disomy encompassing the 11p15.5 and 11p13/WT1 loci and subsequent acquired pathogenic CTNNB1 variants. Somatic coding variants or genome-wide copy number alterations were almost never shared between paired synchronous BWT, suggesting that the acquisition of independent somatic variants leads to tumor formation in the context of germline or early embryonic, post-zygotic initiating events. In contrast, 11p15.5 status (loss of heterozygosity, loss or retention of imprinting) was shared among paired synchronous BWT in all but one case. The predominant molecular events for BWT predisposition include pathogenic germline variants or post-zygotic epigenetic hypermethylation at the 11p15.5 H19/ICR1 locus (loss of imprinting). This study demonstrates that post-zygotic somatic mosaicism for 11p15.5 hypermethylation/loss of imprinting is the single most common initiating molecular event predisposing to BWT. Evidence of somatic mosaicism for 11p15.5 loss of imprinting was detected in leukocytes of a cohort of BWT patients and long-term survivors, but not in unilateral Wilms tumor patients and long-term survivors or controls, further supporting the hypothesis that post-zygotic 11p15.5 alterations occurred in the mesoderm of patients who go on to develop BWT. Due to the preponderance of BWT patients with demonstrable germline or early embryonic tumor predisposition, BWT exhibits a unique biology when compared to unilateral Wilms tumor and therefore warrants continued refinement of its own treatment-relevant biomarkers which in turn may inform directed treatment strategies in the future.
Pushing the Limits of PLA: Exploring the Power of MWCNTs in Enhancing Thermal, Mechanical Properties, and Weathering Resistance
Authors: Younus Mohammed M. , Naguib Hamdy M. , Fekry Mohamed , Elsawy Moataz A. 
Published: March 2023

Abstract
The present study focuses on the enhancement of the mechanical, thermal, and degradation behavior of polylactic acid (PLA) by the addition of carbon nanotubes (CNTs) with different concentrations of 0.5, 1, 3, and 5%. The CNTs were prepared using catalytic chemical vapor deposition, and the prepared PLA/CNTs nanocomposite films were characterized using various techniques such as FT-IR, Raman spectroscopy, TGA, TEM, SEM, and XRD. The XRD results indicated an increase in PLA crystallinity with increasing CNT loading. The mechanical tests showed that the incorporation of CNTs had a positive effect on the elongation at break but decreased the ultimate tensile strength of PLA. The thermal gravimetric analysis showed that the prepared nanocomposites were more thermally stable than pure PLA. The accelerated weathering test results revealed that the surface degradation of the nanocomposites decreased with increasing CNT loading, indicating improved weathering resistance. Overall, the results demonstrate that the addition of conductive CNTs to PLA creates a robust mechanical effect on the PLA matrix and enhances its stability.