bluuebunny/crossref_metadata_2025_split huggingface dataset:
NDVI and grain fill duration are important to be considered in breeding for terminal heat stress tolerance in wheat
Authors: Kumar Monu , Mishra Vinod Kumar , Chand Ramesh , Sharma Sandeep , Kumar Uttam , Jaiswal Jai Prakash , Choudhary Mukesh , Mahato Anima , Ashutosh  , Singh Prashant , Joshi Arun Kumar 
Published: March 2023

AbstractTerminal heat stress is a major constraint for taking a profitable crop of wheat by small and marginal farmers in the Indo‐Gangetic Plains of south Asia. Hence, breeders remain in constant search for heat‐tolerant genotypes. This study was done with the purpose to find out high‐yielding wheat genotypes that perform stably under terminal heat stress as well as to conclude an easy phenotyping trait for this objective. A cross (HUW 234 × HUW 468) was made using two popular cultivars of the eastern Gangetic Plains of India. HUW 234 carries terminal heat tolerance whereas, HUW 468 is high yielding but suffers from terminal heat stress when planted late. So obtained 167 recombinant inbred lines (RILs) were exposed to both timely sown (TS) and late sown (LS) conditions at three locations for two consecutive years 2016–17 and 2017–18 at Varanasi (Uttar Pradesh), Jabalpur (Madhya Pradesh) and Pusa, Samastipur (Bihar). Combined ANOVA revealed that normalized difference vegetation index (NDVI) at anthesis stage (NDVI_AH) and grain filling duration (GFD) was significant for genotype (G), environment (E) and genotype × environment interaction (GEI). Likewise, differences were significant for grain yield (GY) and 1000‐grain weight (TGW). AMMI analysis revealed similar results. However, NDVI_AH showed low variation under heat stressed late sown conditions. Furthermore, the which‐won‐where model and mean versus stability identified the best performing, above‐average yielding and stable lines across the environments. Correlation among measured traits revealed that NDVI_AH had a significant association with GY in most of the environments. Several lines that performed superior to better parent for GY also showed higher values for NDVI_AH and GFD. The study demonstrates that NDVI_AH and GFD appear to be important traits to be considered while breeding for terminal heat stress tolerance in wheat.
Midwives and service users' perspectives on implementing a dialogue about alcohol use in antenatal care: A qualitative study
Authors: Dyson Judith , Onukwugha Franklin , Howlett Helen , Combe Katherine , Catterick Maria , Smith Lesley 
Published: March 2023

AbstractAimThere are barriers to midwives engaging in conversations about alcohol with pregnant women. Our aim was to capture the views of midwives and service users to co‐create strategies to address these barriers.DesignQualitative description.MethodsStructured Zoom‐based focus group interviews of midwives and service users where we presented known barriers and sought solutions to midwives discussing alcohol use in antenatal settings. Data collection took place between July and August 2021.ResultsFourteen midwives and six service users attended five focus groups. Barriers considered were as follows: (i) lack of awareness of guidelines, (ii) poor skills in difficult conversations, (iii) lack of confidence, (iv) lack of belief in existing evidence, (v) women would not listen to their advice, and (vi) alcohol conversations were not considered part of their role. Five strategies to address barriers to midwives discussing alcohol with pregnant women were identified. These were as follows: Training that included mothers of children with Foetal Alcohol Spectrum Disorder, champion midwives, a service user questionnaire about alcohol for completion before the consultation, questions about alcohol added to the maternity data capture template and a structured appraisal to provide a means of audit and feedback on their alcohol dialogue with women.ConclusionsCo‐creation involving providers and users of maternity services yielded theoretically underpinned pragmatic strategies to support midwives to ask advise assist about alcohol during antenatal care. Future research will test if the strategies can be delivered in antenatal care settings, and if they are acceptable to service providers and service users.ImpactIf these strategies are effective in addressing barriers to midwives discussing alcohol with pregnant women, this could support women to abstain from alcohol during pregnancy, thus reducing alcohol‐related maternal and infant harm.Patient and public contributionService users were involved in the design and execution of the study, considering data, supporting intervention design and delivery and dissemination.
Treatment of childhood disruptive behavior disorders and callous‐unemotional traits: a systematic review and two multilevel meta‐analyses
Authors: Perlstein Samantha , Fair Maddy , Hong Emily , Waller Rebecca 
Published: March 2023

BackgroundChildren with callous‐unemotional (CU) traits are at high lifetime risk of antisocial behavior. It is unknown if treatments for disruptive behavior disorders are as effective for children with CU traits (DBD+CU) as those without (DBD‐only), nor if treatments directly reduce CU traits. Separate multilevel meta‐analyses were conducted to compare treatment effects on DBD symptoms for DBD+CU versus DBD‐only children and evaluate direct treatment‐related reductions in CU traits, as well as to examine moderating factors for both questions.MethodsWe systematically searched PsycINFO, PubMed, Cochran Library (Trials), EMBASE, MEDLINE, APA PsycNet, Scopus, and Web of Science. Eligible studies were randomized controlled trials, controlled trials, and uncontrolled studies evaluating child‐focused, parenting‐focused, pharmacological, family‐focused, or multimodal treatments.ResultsSixty studies with 9,405 participants were included (Mage = 10.04, SDage = 3.89 years, 25.09% female, 44.10% racial/ethnic minority). First, treatment was associated with similar reductions in DBD symptoms for DBD+CU (SMD = 1.08, 95% CI = 0.45, 1.72) and DBD‐only (SMD = 1.01, 95% CI = 0.38, 1.64). However, DBD+CU started (SMD = 1.18, 95% CI = 0.57, 1.80) and ended (SMD = 0.73, p < .001; 95% CI = 0.43, 1.04) treatment with more DBD symptoms. Second, although there was no overall direct effect of treatment on CU traits (SMD = .09, 95% CI = −0.02, 0.20), there were moderating factors. Significant treatment‐related reductions in CU traits were found for studies testing parenting‐focused components (SMD = 0.21, 95% CI = 0.06, 0.35), using parent‐reported measures (SMD = 0.16, 95% CI = 0.04, 0.28), rated as higher quality (SMD = 0.26, 95% CI = 0.13, 0.39), conducted outside the United States (SMD = 0.19, 95% CI = 0.05, 0.32), and with less than half the sample from a racial/ethnic minority group (SMD = 0.15, 95% CI = 0.002, 0.30).ConclusionsDBD+CU children improve with treatment, but their greater DBD symptom severity requires specialized treatment modules that could be implemented alongside parenting programs. Conclusions are tempered by heterogeneity across studies and scant evidence from randomized controlled trials.
Electrolyte pH dependence of composition, roughness parameters, particle diameter and magnetic features of nanostructured Fe‐Co‐Ni/ITO deposits prepared by electrochemical deposition method
Authors: Saraç Umut , Trong Dung Nguyen , Baykul M. Celalettin , Long Van Cao , Dang Phu Nguyen , Lan Doan Phuong , Ţălu Ştefan 
Published: March 2023

AbstractThe composition, structural features, surface morphology, roughness parameters, particle size, and magnetic features of nanostructured Fe‐Co‐Ni deposits manufactured on conducting indium tin oxide‐coated glasses at various electrolyte pH values are studied. The deposit produced at low electrolyte pH contains slightly higher Fe and Co contents but lower Ni content compared to deposits fabricated at high pH values. Further composition analysis confirms that the reduction rates of Fe2+ and Co2+ are higher than the Ni2+ reduction rate. The films consist of nano‐sized crystallites with a strong [111] preferred orientation. The results also reveal that the crystallization of the thin films is affected by the electrolyte pH. Surface analysis shows that the deposit surfaces are composed of nano‐sized particles with different diameters. The mean particle diameter and surface roughness decrease as the pH of the electrolyte decreases. The effect of the electrolyte pH on the morphology is also discussed in terms of surface skewness and kurtosis parameters. Magnetic analysis shows that the resultant deposits have in‐plane hysteresis loops with low and close SQR parameters ranging from 0.079 to 0.108. The results also reveal that the coercive field of the deposits increases from 29.4 Oe to 41.3 Oe as the electrolyte pH decreases from 4.7 to 3.2.
European Neuroendocrine Tumor Society (ENETS) 2023 guidance paper for digestive neuroendocrine carcinoma
Authors: Sorbye Halfdan , Grande Enrique , Pavel Marianne , Tesselaar Margot , Fazio Nicola , Reed Nicholas Simon , Knigge Ulrich , Christ Emanuel , Ambrosini Valentina , Couvelard Anne , Tiensuu Janson Eva 
Published: March 2023

AbstractThis ENETS guidance paper, developed by a multidisciplinary working group, provides up‐to‐date and practical advice on the diagnosis and management of digestive neuroendocrine carcinoma, based on recent developments and study results. These recommendations aim to pave the road for more standardized care for our patients resulting in improved outcomes. Prognosis is generally poor for digestive NEC, most are advanced at diagnosis and median survival in metastatic disease is 11–12 months. Surgery can be of benefit for localized disease after extensive preoperative imaging. Carboplatin in combination with etoposide is recommended as first‐line treatment for metastatic disease. Irinotecan with fluoropyrimidines has the best evidence as second‐line treatment. Immunotherapy plays a minor role in biomarker‐unselected patients. Molecular profiling if available is encouraged to identify new targets. More prospective clinical trials are highly needed to fulfil the unmet needs in this field, especially on new predictive and prognostic biomarkers and to improve survival of patients with advanced disease.
Examining craniofacial variation among crispant and mutant zebrafish models of human skeletal diseases
Authors: Diamond Kelly M. , Burtner Abigail E. , Siddiqui Daanya , Alvarado Kurtis , Leake Sanford , Rolfe Sara , Zhang Chi , Kwon Ronald Young , Maga A. Murat 
Published: March 2023

AbstractGenetic diseases affecting the skeletal system present with a wide range of symptoms that make diagnosis and treatment difficult. Genome‐wide association and sequencing studies have identified genes linked to human skeletal diseases. Gene editing of zebrafish models allows researchers to further examine the link between genotype and phenotype, with the long‐term goal of improving diagnosis and treatment. While current automated tools enable rapid and in‐depth phenotyping of the axial skeleton, characterizing the effects of mutations on the craniofacial skeleton has been more challenging. The objective of this study was to evaluate a semi‐automated screening tool can be used to quantify craniofacial variations in zebrafish models using four genes that have been associated with human skeletal diseases (meox1, plod2, sost, and wnt16) as test cases. We used traditional landmarks to ground truth our dataset and pseudolandmarks to quantify variation across the 3D cranial skeleton between the groups (somatic crispant, germline mutant, and control fish). The proposed pipeline identified variation between the crispant or mutant fish and control fish for four genes. Variation in phenotypes parallel human craniofacial symptoms for two of the four genes tested. This study demonstrates the potential as well as the limitations of our pipeline as a screening tool to examine multi‐dimensional phenotypes associated with the zebrafish craniofacial skeleton.
Colporrhaphy using elastic tissue continuous with and obscured behind the fibromuscular layer of the vaginal wall
Authors: Oishi Tetsuya , Kotsuji Fumikazu , Kato Hiroki , Tokuda Hisato , Nakago Satoshi , Shibata Takashi 
Published: March 2023

AbstractAimDue to the U.S. Food and Drug Administration's order to cease the use of surgical mesh for transvaginal repair, an improvement of the native tissue repair (NTR) of pelvic organ prolapse (POP) could become important as one of the first‐line operative methods. This study details the surgical technique of an NTR method we developed, with report of our 5 years of experience.MethodsOperative technique: A new fibromuscular layer (FL) was constructed using a thick and elastic tissue continuous with and obscured behind the original FL of the vaginal wall.Patients: Between April 2017 and March 2020, we performed our novel repair technique on 87 women with POP of either quantification stage III or IV.ResultsWe followed up 80 of the 87 women for over 24 months up to 60 months (follow‐up rate: 91.2%). POP recurred (defined as stage II or higher) in four patients (5.0%). Operation time was 49–70 min. The bleeding volume was 70–250 g. There were no intra‐ or postoperative complications that required further treatment.ConclusionsThis procedure could potentially become one of the first‐line operative methods for repairing POP.
Preconception origins of asthma, allergies and lung function: The influence of previous generations on the respiratory health of our children
Authors: Svanes Cecilie , Holloway John W. , Krauss‐Etschmann Susanne 
Published: March 2023

AbstractEmerging research suggests that exposures occurring years before conception are important determinants of the health of future offspring and subsequent generations. Environmental exposures of both the father and mother, or exposure to disease processes such as obesity or infections, may influence germline cells and thereby cause a cascade of health outcomes in multiple subsequent generations. There is now increasing evidence that respiratory health is influenced by parental exposures that occur long before conception. The strongest evidence relates adolescent tobacco smoking and overweight in future fathers to increased asthma and lower lung function in their offspring, supported by evidence on parental preconception occupational exposures and air pollution. Although this literature is still sparse, the epidemiological analyses reveal strong effects that are consistent across studies with different designs and methodologies. The results are strengthened by mechanistic research from animal models and (scarce) human studies that have identified molecular mechanisms that can explain the epidemiological findings, suggesting transfer of epigenetic signals through germline cells, with susceptibility windows in utero (both male and female line) and prepuberty (male line).The concept that our lifestyles and behaviours may influence the health of our future children represents a new paradigm. This raises concerns for future health in decades to come with respect to harmful exposures but may also open for radical rethinking of preventive strategies that may improve health in multiple generations, reverse the imprint of our parents and forefathers, and underpin strategies that can break the vicious circle of propagation of health inequalities across generations.
Relational Expertise: What Machines Can't Know
Authors: Pakarinen Pauli , Huising Ruthanne 
Published: March 2023

AbstractProfessions continue to be the primary means through which societies institutionalize expertise. Recent analyses and narratives predict that artificial intelligence (AI) will make meaningful inroads into non‐routine reasoning about complex cases, threatening the authority of professions. These predictions, we argue, draw on substantialist understandings of expertise as an intellectual possession, a mental achievement, or a cognitive state performed – by humans or machines – to achieve effects. A synthesis of empirical studies shows that expertise is more accurately conceptualized as relationally constituted – generated, applied, and recognized – through interactions. Relational expertise creates challenges of opacity, translation, and accountability for the development and deployment of AI technologies in the context of professional work. A relational understanding of expertise disrupts notions that professions may be augmented with, subordinated to, or dismantled by AI technologies. Instead, AI technologies are embedded in the network of interactions through which the relational expertise of professions is constituted.
Efficacy and safety of vibegron compared with mirabegron for overactive bladder: A systematic review and network meta‐analysis
Authors: He Wenjuan , Zhang Yuqian , Huang Guangliang , Tian Yunfei , Sun Qian , Liu Xiuju 
Published: March 2023

AbstractObjectivesThe aim of this study was to indirectly compare the efficacy and safety of mirabegron and vibegron in patients with overactive bladder.MethodsA systematic search was performed on Pubmed, Web of Science, Embase, and the Cochrane Central Register of Controlled Trials databases to identify studies from the date of database inception to January 1, 2022. All randomized controlled trials comparing mirabegron or vibegron with tolterodine, imidafenacin, or placebo were eligible. One reviewer extracted data, and a second reviewer checked. Included trials were assessed for similarity, and networks were developed using Stata 16.0 software. Mean differences for continuous variables and odds ratios for dichotomous variables together with their 95% confidence intervals (CIs) were used to rank treatments and compare the differences, respectively.ResultsA total of 11 randomized controlled trials and 10 806 patients were included. For each outcome, results for all licensed treatment doses were included. Both vibegron and mirabegron were more efficacious than placebo at reducing the frequency of micturition, incontinence, urgency, urgency incontinence, and nocturia. Vibegron was more efficacious than mirabegron in reducing mean voided volume/micturition (95% CI [5.15, 14.98]). Safety outcomes for vibegron and mirabegron were similar to those in the placebo group, except for mirabegron, which had a higher risk of nasopharyngitis and cardiovascular adverse events than placebo.ConclusionsBoth drugs seem to be comparable and well tolerated, particularly as direct comparisons are not available. However, vibegron may be more effective than mirabegron in reducing mean voided volume.
A decentralized robust control approach for virtually coupled train sets
Authors: Vaquero‐Serrano Miguel A. , Felez Jesus 
Published: March 2023

AbstractIn this paper, a novel approach to train control systems based on virtual coupling is presented. Virtual coupling is a concept that has evolved from platooning of vehicles and allows to reduce the distance and headway between trains without constructing new lines while ensuring safe operation. With this objective in mind, we propose a decentralized robust model predictive control (MPC) framework for a virtually coupled train set based on a min–max approach. Unlike the nominal MPC, robust MPC is designed to consider external undetermined disturbances and errors to improve robustness in real‐world applications. Therefore, in this study, we present the formulation of a robust MPC based on solving a finite‐horizon optimization problem with bounded uncertainties. The bounds consider resistive modeling errors, positioning errors, communication delays, and a possible adhesion loss of up to 10%. We then performed four simulations to compare the behavior of the robust MPC with the equivalent nominal MPC. In these simulations, we simulated a metro line, main line, and high‐speed line. The simulations also analyzed the behavior of the robust MPC under the considered perturbations and different communication delays. The results show that the robust MPC ensures safer operation than nominal MPC in subways, conventional lines, and high‐speed lines. Future research can focus on centralized MPC and artificial intelligence.
Effects of Astragalus polysaccharide to boar sperm on bisphenol A exposure
Authors: Hu Qimeng 
Published: March 2023

AbstractBisphenol A (BPA) is reported to impair male fertility. The alleviating effect of Astragalus polysaccharide (APS) on sperm oxidative damage caused by BPA exposure was analysed for the first time. In this study, the effect of APS (0.25, 0.5, 0.75, 1 mg/mL) on motility of BPA‐exposed sperm, energy metabolism indexes, and antioxidant parameters was evaluated. In addition, the effects of APS supplementation on protein tyrosine phosphorylation of BPA‐exposed sperm were assessed. The results showed that the addition of APS (0.5 and 0.75 mg/mL) significantly increased motility of BPA‐exposed sperm by decreasing the content of malondialdehyde and improving activities of superoxide dismutase and catalase (p < .05). Administration of different doses of APS to BPA‐exposed sperm improved mitochondrial membrane potential and energy production (p < .05). Moreover, APS protected and alleviated tyrosine phosphorylation protein on the principal‐pieces of BPA‐exposed sperm flagella. In conclusion, supplementation with APS enhanced the antioxidant capacity of BPA‐exposed sperm and improved in vitro capacitation, thereby improving the reproductive capacity of sperm exposed to environmental hormones.
Establishing an empirical conceptual model of oral health in dependent adults: Systematic review
Authors: BaHammam Fahad A. , Akhil Jamal , Stewart Margaret , Abdulmohsen Bana , Durham Justin , McCracken Giles I. , Wassall Rebecca 
Published: March 2023

AbstractAimThis qualitative evidence synthesis was performed to establish a conceptual model of oral health in dependent adults that defines the construct of oral health and describes its interrelationships based on dependent adults’ and their caregivers’ experiences and views.MethodsSix bibliographic databases were searched: MEDLINE, Embase, PsycINFO, CINAHL, OATD, and OpenGrey. Citations and reference lists were manually searched. A quality assessment of included studies was conducted independently by two reviewers using the Critical Appraisal Skills Programme (CASP) checklist. The ‘best fit’ framework synthesis method was applied. Data were coded against an a priori framework and data not captured by this framework were thematically analyzed. To assess the confidence of the findings from this review, the Confidence in the Evidence from Reviews of Qualitative research (GRADE‐CERQual) approach was used.ResultsTwenty‐seven eligible studies were included from 6126 retrieved studies. Four themes were generated to further understand oral health in dependent adults: oral health status, oral health impact, oral care, and oral health value.ConclusionThis synthesis and conceptual model offer a better understanding of oral health in dependent adults and subsequently provide a starting point to guide establishment of person‐centred oral care interventions.