bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stretchable, Breathable, and Washable Fabric Sensor for Human Motion Monitoring
Authors: Sanchez‐Botero Lina , Agrawala Anjali , Kramer‐Bottiglio Rebecca 
Published: July 2023

AbstractWearable strain sensors for movement tracking are a promising paradigm to improve clinical care for patients with neurological or musculoskeletal conditions, with further applicability to athletic wear, virtual reality, and next‐generation game controllers. Clothing‐like wearable strain sensors can support these use cases, as the fabrics used for clothing are generally lightweight and breathable, and interface with the skin in a manner that is mechanically and thermally familiar. Herein, a fabric capacitive strain sensor is presented and integrated into everyday clothing to measure human motions. The sensor is made of thin layers of breathable fabrics and exhibits high strains (>90%), excellent cyclic stability (>5000 cycles), and high water vapor transmission rates (≈50 g/h m2), the latter of which allows for sweat evaporation, an essential parameter of comfort. The sensor's functionality is verified under conditions similar to those experienced on the surface of the human body (35°C and % relative humidity) and after washing with fabric detergent. In addition, the fabric sensor shows stable capacitance at excitation frequencies up to 1 MHz, facilitating its low‐cost implementation in the Arduino environment. Finally, as a proof of concept, multiple fabric sensors are seamlessly integrated with commercial activewear to collect movement data. With the prioritization of breathability (air permeability and water vapor transmission), the fabric sensor design presented herein paves the way for future comfortable, unobtrusive, and discrete sensory clothing.
Customize Aramid Nanofiber Aerogels with High Electromagnetic Shielding Performance from Ultra‐Malleable Kevlar‐Derived Jelly
Authors: Zhang Zongwen , Wang Chunhui , Luo Yuanping , Yuan Changxin , Hu Wanbiao 
Published: July 2023

AbstractIt is important but challenging to develop high‐performance electromagnetic interference (EMI) shielding materials with customizable structures, tailorable properties, light weight, and high‐efficiency EMI shielding effectiveness (SE). Herein, a facile approach is proposed to customize aramid nanofiber (ANF) based EMI shielding aerogels with pre‐designed architectures through ultra‐malleable ANF jellies. By precisely regulating the interfiber interactions between ANF and constructing a robust 3D skeleton, ANF jelly can be ‘kneaded‐frozen‐heated’ like dough to produce ultralight, elastic and porous ANF aerogels with special structures, such as aerogel sandwich, spring, fabric, etc. Benefiting from the interconnected porous structure, conductive fillers such as silver nanowires (AgNW) can easily cover the aerogel skeleton by dip‐coating to form highly conductive paths. With an ultra‐low loading (7.5 wt.%) of AgNW, a 5.2 mm‐thick AgNW/ANF aerogel exhibit an average EMI SE of 75.4 dB in the X‐band. Aerogels with additional functions can be customized according to the actual application environment. A customized sandwich aerogel with fire‐retardant outerlayer and EMI shielding interlayer can be used in high‐temperature environments. A flexible aerogel fabric as an EMI shielding gasket can effectively block wireless power transmission. This work provides a forward‐looking strategy for constructing high‐performance EMI shielding materials with tailored properties.
Radical‐Mediated Hydroperfluoroalkylation of Unactivated Alkenes
Authors: Sissengaliyeva Gulsana , Dénès Fabrice , Girbu Vladilena , Kulcitki Veaceslav , Hofstetter Elena , Renaud Philippe 
Published: July 2023

AbstractThe direct hydroperfluoroalkylation of a wide range of unactivated alkenes has been achieved at room temperature with readily available iodoperfluoroalkanes using 4‐tert‐butylcatechol as a source of hydrogen atom and triethylborane. The hydrotrifluoromethylation could also be achieved under these conditions using gaseous trifluoromethyl iodide. An experimentally simple two‐step, one‐pot hydrotrifluoromethylation process using the easy‐to‐use trifluoromethanesulfonyl chloride as the source of trifluoromethyl radicals has also been developed. Using these two approaches, a broad range of substrates, including isoprenoid natural products, were efficiently derivatized.
S100A5 Attenuates Efficiency of Anti‐PD‐L1/PD‐1 Immunotherapy by Inhibiting CD8+ T Cell‐Mediated Anti‐Cancer Immunity in Bladder Carcinoma
Authors: Li Huihuang , Chen Jinbo , Li Zhenghao , Chen Minfeng , Ou Zhenyu , Mo Miao , Wang Ruizhe , Tong Shiyu , Liu Peihua , Cai Zhiyong , Zhang Chunyu , Liu Zhi , Deng Dingshan , Liu Jinhui , Cheng Chunliang , Hu Jiao , Zu Xiongbing 
Published: July 2023

AbstractAlthough immune checkpoint blockade (ICB) therapies have been approved for bladder cancer (BLCA), only a minority of patients respond to these therapies, and there is an urgent need to explore combined therapies. Systematic multi‐omics analysis identified S100A5 as a novel immunosuppressive target for BLCA. The expression of S100A5 in malignant cells inhibited CD8+ T cell recruitment by decreasing pro‐inflammatory chemokine secretion. Furthermore, S100A5 attenuated effector T cell killing of cancer cells by inhibiting CD8+ T cell proliferation and cytotoxicity. In addition, S100A5 acted as an oncogene, thereby promoting tumor proliferation and invasion. Targeting S100A5 synergized with the efficacy of anti‐PD‐1 treatment by enhancing infiltration and cytotoxicity of CD8+ T cells in vivo. Clinically, there was a spatially exclusive relationship between S100A5+ tumor cells and CD8+ T cells in tissue microarrays. Moreover, S100A5 negatively correlated with immunotherapy efficacy in our real‐world and several public immunotherapy cohorts. In summary, S100A5 shapes a non‐inflamed tumor microenvironment in BLCA by inhibiting the secretion of pro‐inflammatory chemokines and the recruitment and cytotoxicity of CD8+ T cells. Targeting S100A5 converts cold tumors into hot tumors, thus enhancing the efficacy of ICB therapy in BLCA.
Effect of Gadolinium on Electrical Properties of Polyethyleneimine Functionalized and Nitrogen‐Doped Graphene Quantum Dot Nanocomposite Based Diode
Authors: Orhan Elif , Anter Aslıhan , Ulusoy Murat , Polat Barış , Okuyucu Can , Yıldız Mustafa , Altındal Şemsettin 
Published: July 2023

AbstractCarbon, especially graphene quantum dots (GQDs) based electronics have become an attractive technology in recent years. The controlled modification of the electrical and optoelectronic properties of GQDs by physical/chemical processes or synthetic methods may lead to new applications. Gadolinium‐doped polyethyleneimine (PEI) functionalized and nitrogen‐doped graphene quantum dots (GdNPs‐PEI@N‐GQDs) are synthesized by a hydrothermal method to determine how doping carbon‐based materials with Gd alters the electrical properties of the structure. The electrical properties of the GdNPs/PEI@N‐GQDs nanocomposite‐based diode are investigated using the current–voltage (I–V) technique and the capacitance and conductance voltage (C–V & G/ω–V) technique at 300 K in the frequency range of 0.5 to 500 kHz at ± 5 V. The rectification ratio (RR) is found to be 14 at a voltage of ±5 V. The rectifying behavior of the diode changes to an ohmic behavior after doping with Gd, compared to the Gd‐free PEI@N‐GQDs sample (2.8 × 104 at ±5 V). The results are expected to have an impact on the understanding of carbon‐based electronics technology.
Full‐Hexacyanometallate Aqueous Redox Flow Batteries Exceeding 1.5 V in an Aqueous Solution
Authors: Jang Ji‐Eun , Kim Ryeong‐ah , Jayasubramaniyan S. , Lee Chanhee , Choi Jieun , Lee Youngdae , Kang Sujin , Ryu Jaechan , Lee Seok Woo , Cho Jaephil , Lee Dong Woog , Song Hyun‐Kon , Choe Wonyoung , Seo Dong‐Hwa , Lee Hyun‐Wook 
Published: July 2023

AbstractAqueous redox flow batteries (RFBs) have attracted significant attention as energy storage systems by virtue of their inexpensive nature and long‐lasting features. Although all‐vanadium RFBs exhibit long lifetimes, the cost of vanadium resources fluctuates considerably, and is generally expensive. Iron–chromium RFBs take advantage of utilizing a low‐cost and large abundance of iron and chromite ore; however, the redox chemistry of CrII/III generally involves strong Jahn–Teller effects. Herein, this work introduces a new Cr‐based negolyte coordinated with strong‐field ligands capable of mitigating strong Jahn–Teller effects, thereby facilitating low redox potential, high stability, and rapid kinetics. The balanced full‐cell configuration features a stable lifetime of 500 cycles with energy density of 14 Wh L−1. With an excessive posolyte, the full‐cell can attain a high energy density of 38.6 Wh L−1 as a single electron redox process. Consequently, the proposed system opens new avenues for the development of high‐performance RFBs.
Zwitterionic Polymer Gel‐Based Fully Self‐Healable Ionic Thermoelectric Generators with Pressure‐Activated Electrodes
Authors: Ho Dong Hae , Kim Yong Min , Kim Ui Jin , Yu Kyeong Su , Kwon Jin Han , Moon Hong Chul , Cho Jeong Ho 
Published: July 2023

AbstractHeat generated from various sources is inevitably wasted. Thermoelectric generators (TEGs) are suitable for recovering such waste heat because of their simple structure and operating principle. Herein, a zwitterionic (ZI) polymer‐based fully self‐healable ionic TEG is presented. By adjusting the position of the positive and negative moieties of the ZI side chain, the movement of free ions contained in the ionogel can be controlled effectively, thus improving the power factor of TEGs. ZI side chains inside the ionogel provide multiple ionic interaction sites and enable fast self‐healing characteristics at room temperature. Furthermore, a self‐healing electrode composed of liquid metal (LM), waterborne polyurethane (WPU), and polyvinyl alcohol (PVA) is developed for the fully healable TEGs. The overall areal output voltage is effectively improved by connecting 10 legs of p and n thermoelectric gels in series via a self‐healing process. The selectively ion‐boosted, fully self‐healable TEGs developed in this study will open a new horizon for high‐performance ionic TEGs.
Rethinking the Electrode Multiscale Microstructures: A Review on Structuring Strategies toward Battery Manufacturing Genome
Authors: Fu Xuewei , Zhou Yonghan , Huang Jieyang , Feng Lanxiang , Yu Peng , Zhang Qiang , Yang Wei , Wang Yu 
Published: July 2023

AbstractThe success of liquid/solid‐state batteries is fundamentally determined by the electrode microstructures, which is particularly true for high‐energy‐density electrodes with either thick configuration or high‐capacity active materials. Unfortunately, high‐energy‐density electrodes usually suffer from fast performance degradation due to various challenging issues in microstructures. Therefore, a better understanding of electrode microstructures and the strategies toward optimizing them are in urgent need by the research community and battery industries. In this review, the authors attempt to rethink and comprehensively understand the multiscale microstructures for particularly thick electrodes and to summarize the corresponding structuring strategies. Specifically, in analogy to proteins, the multiscale electrode microstructures are classified into the primary structures of rigid building blocks, the secondary structures of active material microenvironment, and the tertiary structures of electrode architectures. Meanwhile, the design principles and structuring strategies at different levels of microstructures are detailed with consideration given to efficiency, energy consumption, eco‐friendliness, and scalability. Finally, a concept of a battery manufacturing genome based on structuring strategy profile (similar to amino acid profile) is proposed as the forthcoming opportunity for the future connection of machine learning with battery microstructure optimization, which may promote the development of next‐generation on‐demand batteries.
Non‐Covalent Interactions Enforce Conformation in Switchable and Water‐Soluble Diketopiperazine‐Pyridine Foldamers
Authors: McCann Sinead , Roe William E. , Agnew Hannah E. , Knipe Peter C. 
Published: July 2023

AbstractTo reach their potential as mimics of the dynamic molecules present in biological systems, foldamers must be designed to display stimulus‐responsive behavior. Here we report such a foldamer architecture based on alternating pyridine‐diketopiperazine linkers. Epimerization is conveniently prevented through a copper‐catalyzed coupling protocol. The compounds’ native unswitched conformation is first discovered in the solid and solution state. The foldamers can be solubilized in DMSO and pH 9.5 buffer, retaining conformational control to a large degree. Lastly, dynamic switching is demonstrated through treatment with acid, leading to behaviour we describe as stimulus‐responsive sidechain reconfiguration.
Fabrication of konjac glucomannan‐silk fibroin based biomimetic scaffolds for improved vascularization and soft tissue engineering applications
Authors: Thangavel Ponrasu , Kanniyappan Hemalatha , Chakraborty Sudip , Chaudhary Shipra , Wallepure Aadinath , Muthuvijayan Vignesh 
Published: July 2023

AbstractThe biomimetic scaffolds were fabricated using two natural biopolymers; Konjac glucomannan (KGM) and Silk fibroin (SF). The various proportions of KGM (1%) and SF (1%–2%) solutions were cross‐linked using citric acid as a cross linker and then lyophilized to prepare the fibrous scaffolds. The physicochemical properties of the KGM/SF scaffolds were investigated using FT‐IR analysis, TGA analysis, SEM, porosity, swelling, in vitro biodegradation, and mechanical characterization. FTIR spectra revealed the presence of characteristic functional moieties in the KGM/SF scaffolds. The improved thermal stability was observed for KGM/SF scaffolds compared to the control. The SEM images revealed that the scaffolds exhibited a porous morphology. The biodegradation of KGM/SF scaffolds was almost 77% until day 21, showing the biodegradable nature of the KGM/SF scaffolds. The compression strength of KGM/SF scaffolds was significantly higher than the KGM scaffold and eligible for soft tissue engineering. The KGM/SF scaffolds were further characterized by in vitro cell viability and cell attachment in fibroblast cells, demonstrating the non‐toxicity of scaffolds. Finally, in vivo CAM assay was successfully performed and determined the efficacy of KGM/SF scaffolds in vascularization. Overall, the results demonstrated that the KGM/SF scaffolds are biocompatible and capable of promoting vascularization in tissue engineering and biomedical applications.
Non‐planar polyimides with monomer containing four triphenylamines for near‐infrared electrochromism and TNP detection
Authors: Ma Yufan , Xia Shixuan , Zhai Minghao , Zhang Ce , Hong Tianjiao , Zhang Baixin , Cai Wan‐an , Niu Haijun , Wang Wen 
Published: July 2023

AbstractBy using triphenylamine (TPA) with a propeller structure connected to the planar fluorene unit as monomer, three novel polyimide (PI)s were prepared through chemical imidization of N,N′‐(9,9‐bis(4‐(diphenylamino) phenyl)‐9H‐fluorene‐2,7‐diyl)‐bis(N‐(4‐methoxyphenyl) benzene‐1,4‐diamine) (TPAF‐NH2) with three kinds of dianhydrides. The three dimensional configurations are designed to decrease molecular stacking rising from strong imide bond, and for faster ion transport in cavity of PIs. All the three PIs have good performance of electrochromic(EC) and sensor. With the voltage increasing from 0 to 1.2 V, the color of P2 film changes from original yellow to red to blue with the response time of only 2.3 s (colored time [tc]) and 2.8 s (bleached time [tb]). The coloring efficiency (CE) of P2 reaches 310 cm2 C−1, with optical contrast (ΔT) of 54%. Especially, the electroactivity of P3 does not decrease significantly after 6000 s cycle. Additionally, there are dual‐band in near‐infrared (NIR) area after the PI being oxidized. P1 with photoluminescence (PL) quantum efficiency (φPL) of 48% can detect trinitrophenol (TNP) effectively. The novel PIs have promising prospect in NIR EC and TNP detection devices.
Rheological studying the effect of reduced graphene oxide nanoparticles on the creep behavior of epoxy coating of pipelines: Part I—Constitutive equations
Authors: Gholizadeh Asghar , Vakili‐Tahami Farid , Adibeig Mohammad Reza 
Published: July 2023

AbstractIn this article, the creep behavior of pure and reinforced epoxy‐polyamine samples with different amounts of reduced graphene oxide (RGO) at two temperature levels of 28 and 40°C is investigated experimentally and analytically to develop the creep‐associated constitutive equations. Mechanical properties and creep behavior of samples are obtained by carrying out tensile and creep tests at different stress levels. The Burgers model and modified Burgers model are used to investigate the creep behavior of pure and reinforced epoxy. The experimental results show that the addition of 0.5% RGO increases the yield strength of the samples by 51% and the maximum strain by 20%. Also, by considering the production costs of reinforced epoxy, the sample reinforced with 0.5 wt% graphene is selected as the optimum added value of RGO nanoparticles which results in the desired failure load and creep resistance. Additionally, it is discovered that the modified Burgers model, albeit having a larger computing cost, can accurately simulate samples' creep behavior. Furthermore, Fourier transform infrared spectroscopy and scanning electron microscopy analyses are performed on the samples and it is found that the addition of RGO particles improves the microstructure of the reinforced samples.
Co Single Atoms Anchored in N and P Co‐doped Porous Carbon Fibers for Efficient Water Splitting
Authors: Li Jie , Zhu Jiahui , Jia Ziqi , Li Rumin , Yu Jing 
Published: July 2023

AbstractSingle atom catalysts (SACs) show potential application for highly efficient water splitting. Herein, we designed Co single atoms (SAs) dispersed on N and P co‐doped porous carbon nanofibers as electrocatalysts for hydrogen evolution reaction (HER) and oxygen evolution reaction (OER). The configuration of Co SAs is proved to coordinate with 4 N/O atoms. The long‐range interactions between doped P atoms and Co−N4(O) sites could modulate the electronic structures of M−N4(O) sites, which greatly reduce the adsorption energies of HER and OER intermediates at metal sites. Density Functional Theory calculations reveal that CoSA/CNFs exhibits optimized HER and OER kinetics when P coordinates with two N atoms. The atomically dispersed Co electrocatalyst exhibits the low overpotentials of 61, 89 and 390 mV for acidic HER, alkaline HER and OER at 10 mA cm−2 current density, along with the Tafel slope of 54, 143 and 74 mV dec−1, respectively. This work demonstrates the prospect of utilizing di‐heteroatom‐doping transition metal SACs, and provides a novel and general strategy for the preparation of SACs.
Enantioselective Synthesis of Octahydrofuranoindole Core of Aspidosperma Alkaloids via a Diels‐Alder/Reduction/Fluoroetherification Reaction Sequence
Authors: Prasad Madavi S. , Bharani Ms. Sankar , Jha Mr. Aman Kumar , Naik Mr. Sugali Chetan , Sivaprakash Murugesan , Chowhan L. Raju 
Published: July 2023

AbstractHerein, we disclose the enantioselective synthesis of novel tricyclic fluorooctahydrofuranoindole spirooxindoles bearing five contiguous stereocenters via an organocatalytic sequential Diels‐Alder/Reduction/Fluoroetherifiction reaction strategy. The potential of the developed approach was witnessed by generating vast examples (up to 20 examples) of library molecules embedding natural product core with good yields and phenomenal diastereo‐ and enantioselectivities (up to 77 % overall yield, up to 99 % ee and 10 : 1 dr). The synthetic utility of our protocol was further demonstrated by synthesizing tricyclic iodooctahydroindole spirooxindole framework through sequential Diels‐Alder/reduction/iodoetherification reaction in 65 % overall yield and excellent stereoselectivity (99 % ee and 4 : 1 dr).
Glucose oxidase virus‐based nanoreactors for smart breast cancer therapy
Authors: Gama Pedro , Juárez Patricia , Rodríguez‐Hernández Ana G. , Vazquez‐Duhalt Rafael 
Published: July 2023

AbstractBackgroundBreast cancer is the most common malignant tumor disease and the leading cause of female mortality. The evolution of nanomaterials science opens the opportunity to improve traditional cancer therapies, enhancing therapy efficiency and reducing side effects.Methods and major resultsHerein, protein cages conceived as enzymatic nanoreactors were designed and produced by using virus‐like nanoparticles (VLPs) from Brome mosaic virus (BMV) and containing the catalytic activity of glucose oxidase (GOx) enzyme. The GOx enzyme was encapsulated into the BMV capsid (VLP‐GOx), and the resulting enzymatic nanoreactors were coated with human serum albumin (VLP‐GOx@HSA) for breast tumor cell targeting. The effect of the synthesized GOx nanoreactors on breast tumor cell lines was studied in vitro. Both nanoreactor preparations VLP‐GOx and VLP‐GOx@HSA showed to be highly cytotoxic for breast tumor cell cultures. Cytotoxicity for human embryonic kidney cells was also found. The monitoring of nanoreactor treatment on triple‐negative breast cancer cells showed an evident production of oxygen by the catalase antioxidant enzyme induced by the high production of hydrogen peroxide from GOx activity.Conclusions and implicationsThe nanoreactors containing GOx activity are entirely suitable for cytotoxicity generation in tumor cells. The HSA functionalization of the VLP‐GOx nanoreactors, a strategy designed for selective cancer targeting, showed no improvement in the cytotoxic effect. The GOx containing enzymatic nanoreactors seems to be an interesting alternative to improve the current cancer therapy. In vivo studies are ongoing to reinforce the effectiveness of this treatment strategy.
Brain networks and epilepsy development in patients with Alzheimer disease
Authors: Lee Dong Ah , Lee Ho‐Joon , Kim Si Eun , Park Kang Min 
Published: July 2023

AbstractIntroductionThis study aimed to investigate the association between brain networks and epilepsy development in patients with Alzheimer disease (AD).MethodsWe enrolled patients newly diagnosed with AD at our hospital who underwent three‐dimensional T1‐weighted magnetic resonance imaging at the time of AD diagnosis and included healthy controls. We obtained the cortical, subcortical, and thalamic nuclei structural volumes using FreeSurfer and applied graph theory to obtain the global brain network and intrinsic thalamic network based on the structural volumes using BRAPH.ResultsWe enrolled 25 and 56 patients with AD with and without epilepsy development, respectively. We also included 45 healthy controls. The global brain network differed between the patients with AD and healthy controls. The local efficiency (2.026 vs. 3.185, p = .048) and mean clustering coefficient (0.449 vs. 1.321, p = .024) were lower, whereas the characteristic path length (0.449 vs. 1.321, p = .048) was higher in patients with AD than in healthy controls. Both global and intrinsic thalamic networks were significantly different between AD patients with and without epilepsy development. In the global brain network, local efficiency (1.340 vs. 2.401, p = .045), mean clustering coefficient (0.314 vs. 0.491, p = .045), average degree (27.442 vs. 41.173, p = .045), and assortative coefficient (−0.041 vs. −0.011, p = .045) were lower, whereas the characteristic path length (2.930 vs. 2.118, p = .045) was higher in patients with AD with epilepsy development than in those without. In the intrinsic thalamic network, the mean clustering coefficient (0.646 vs. 0.460, p = .048) was higher, whereas the characteristic path length (1.645 vs. 2.232, p = .048) was lower in patients with AD with epilepsy development than in those without.ConclusionWe found that the global brain network differs between patients with AD and healthy controls. In addition, we demonstrated significant associations between brain networks (both global brain and intrinsic thalamic networks) and epilepsy development in patients with AD.