bluuebunny/crossref_metadata_2025_split huggingface dataset:
Initial Evidence for the Efficacy of Naporafenib in Combination With Trametinib in NRAS-Mutant Melanoma: Results From the Expansion Arm of a Phase Ib, Open-Label Study
Authors: de Braud Filippo , Dooms Christophe , Heist Rebecca S. , Lebbe Celeste , Wermke Martin , Gazzah Anas , Schadendorf Dirk , Rutkowski Piotr , Wolf Jürgen , Ascierto Paolo A. , Gil-Bazo Ignacio , Kato Shumei , Wolodarski Maria , McKean Meredith , Muñoz Couselo Eva , Sebastian Martin , Santoro Armando , Cooke Vesselina , Manganelli Luca , Wan Kitty , Gaur Anil , Kim Jaeyeon , Caponigro Giordano , Couillebault Xuân-Mai , Evans Helen , Campbell Catarina D. , Basu Sumit , Moschetta Michele , Daud Adil 
Published: March 2023

PURPOSE No approved targeted therapy for the treatment of patients with neuroblastoma RAS viral (v-ras) oncogene homolog ( NRAS)–mutant melanoma is currently available. PATIENTS AND METHODS In this phase Ib escalation/expansion study (ClinicalTrials.gov identifier: NCT02974725 ), the safety, tolerability, and preliminary antitumor activity of naporafenib (LXH254), a BRAF/CRAF protein kinases inhibitor, were explored in combination with trametinib in patients with advanced/metastatic KRAS- or BRAF-mutant non–small-cell lung cancer (escalation arm) or NRAS-mutant melanoma (escalation and expansion arms). RESULTS Thirty-six and 30 patients were enrolled in escalation and expansion, respectively. During escalation, six patients reported grade ≥3 dose-limiting toxicities, including dermatitis acneiform (n = 2), maculopapular rash (n = 2), increased lipase (n = 1), and Stevens-Johnson syndrome (n = 1). The recommended doses for expansion were naporafenib 200 mg twice a day plus trametinib 1 mg once daily and naporafenib 400 mg twice a day plus trametinib 0.5 mg once daily. During expansion, all 30 patients experienced a treatment-related adverse event, the most common being rash (80%, n = 24), blood creatine phosphokinase increased, diarrhea, and nausea (30%, n = 9 each). In expansion, the objective response rate, median duration of response, and median progression-free survival were 46.7% (95% CI, 21.3 to 73.4; 7 of 15 patients), 3.75 (95% CI, 1.97 to not estimable [NE]) months, and 5.52 months, respectively, in patients treated with naporafenib 200 mg twice a day plus trametinib 1 mg once daily, and 13.3% (95% CI, 1.7 to 40.5; 2 of 15 patients), 3.75 (95% CI, 2.04 to NE) months, and 4.21 months, respectively, in patients treated with naporafenib 400 mg twice a day plus trametinib 0.5 mg once daily. CONCLUSION Naporafenib plus trametinib showed promising preliminary antitumor activity in patients with NRAS-mutant melanoma. Prophylactic strategies aimed to lower the incidence of skin-related events are under investigation.
Green Walls: Everyday Ecofascism and the Politics of Proximity
Authors: Anson April , Banerjee Anindita 
Published: March 2023

AbstractQAnon's rallying cry of “the storm” on January 6 and thereafter articulates a structural taxonomy of planetary scale and apocalyptic eschatology that pervades the environmental imaginaries of contemporary fascism. While they become visible only in times of emergency and states of exception, this essay argues that equal attention needs to be paid to expressions and operations of ecofascism in the mundane places and practices of everyday life. Expanding beyond the geographic and historical specificities of Nazism and its transatlantic dialogue with North American settler colonialism, this essay theorizes everyday ecofascism as an oiko-logics and oiko-nomics across borders, a transversal condition of deeply globalized, inextricably interconnected structures and systems.
Formulation and in vitro evaluation of meloxicam as a self-microemulsifying drug delivery system
Authors: Muhammed Saja Abdulkareem , Al-Kinani Khalid Kadhem 
Published: March 2023

Background: The nonsteroidal anti-inflammatory medication meloxicam (MLX) belongs to the oxicam family and is used to reduce inflammation and pain. The aim of this study was to improve MLX's dispersibility and stability by producing it as a liquid self-microemulsifying drug delivery system since it is practically insoluble in water. Methods: Five different formulations were made by adjusting the amounts of propylene glycol, Transcutol P, Tween 80, and oleic acid oil and establishing a pseudo-ternary diagram in ratios of 1:1, 1:2, 1:3, 1:4, and 3:4, respectively. All of the prepared formulations were tested for a variety of properties, including thermodynamic stability, polydispersity index, particle size distributions, dilution resistance, drug contents, dispersibility, in vitro solubility of the drug, and emulsification time. Results: F5 was chosen as the optimal MLX liquid self-microemulsion due to its higher drug content (99.8%), greater in vitro release (100% at 40 min), smaller droplet size (63 nm), lower polydispersity index (PDI) value (0.3), and higher stability (a zeta potential of -81 mV). Conclusions: According to the data provided here, the self-microemulsifying drug delivery system is the most practical method for improving the dispersibility and stability of MLX.
Measuring Benefits from New Products in Markets with Information Frictions
Authors: Morozov Ilya 
Published: March 2023

I study how much consumers benefit from new products in markets with information frictions. I analyze new products in the U.S. hard drive market, which is characterized by ample product innovation. Using unique click-stream data, I measure the magnitude of two frictions, category consideration and costly search, and show that both play a crucial role in shaping consumer demand. To estimate consumer surplus from new products, I develop a search model that captures both frictions and propose a novel Bayesian estimation method to recover its parameters. I then show that ignoring information frictions leads researchers to underestimate the consumer surplus from new hard drives because it appears that consumers do not value the combinations of attributes these hard drives offer. Partly eliminating frictions, through marketing efforts or market-wide transparency initiatives, can help consumers to more fully internalize the benefits of new product launches. This paper was accepted by Matthew Shum, marketing. Supplemental Material: The data files and online appendices are available at https://doi.org/10.1287/mnsc.2023.4729 .
High-resolution astronomical spectrograph design method with a single echelle grating
Authors: Kukushkin Dmitrii E. , Sazonenko Dmitrii A. , Valyavin Gennady G. , Bakholdin Alexey V. 
Published: March 2023

The paper presents a method for calculation of the main paraxial and
energy parameters of a high-resolution astronomical spectrograph with
a single echelle grating in a wide spectral range, without
cross-dispersion elements. We consider two variants of the system
design, namely, with a fixed grating (spectrograph) and with a movable
grating (monochromator). Based on the analysis of the spectral
resolution dependence on the echelle grating characteristics and the
collimated beam diameter, the limits of the achievable maximum
spectral resolution of the system are determined. The results obtained
in this work can simplify the choice of the starting point for
spectrograph designing. As an example of the presented method
application design of the spectrograph for the Large Solar
Telescope-coronagraph LST-3, operating in the spectral range of
390–900 nm, with spectral resolving power of R=200,000 and minimum diffraction efficiency of
the echelle grating I
g
>0.68, is considered.
The social media diet: A scoping review to investigate the association between social media, body image and eating disorders amongst young people
Authors: Dane Alexandra , Bhatia Komal 
Published: March 2023

Background
Eating disorders are a group of heterogenous, disabling and deadly psychiatric illnesses with a plethora of associated health consequences. Exploratory research suggests that social media usage may be triggering body image concerns and heightening eating disorder pathology amongst young people, but the topic is under-researched as a global public health issue.

Aim
To systematically map out and critically review the existing global literature on the relationship between social media usage, body image and eating disorders in young people aged 10–24 years.

Methods
A systematic search of MEDLINE, PyscINFO and Web of Science for research on social media use and body image concerns / disordered eating outcomes published between January 2016 and July 2021. Results on exposures (social media usage), outcomes (body image, eating disorders, disordered eating), mediators and moderators were synthesised using an integrated theoretical framework of the influence of internet use on body image concerns and eating pathology.

Results
Evidence from 50 studies in 17 countries indicates that social media usage leads to body image concerns, eating disorders/disordered eating and poor mental health via the mediating pathways of social comparison, thin / fit ideal internalisation, and self-objectification. Specific exposures (social media trends, pro-eating disorder content, appearance focused platforms and investment in photos) and moderators (high BMI, female gender, and pre-existing body image concerns) strengthen the relationship, while other moderators (high social media literacy and body appreciation) are protective, hinting at a ‘self-perpetuating cycle of risk’.

Conclusion
Social media usage is a plausible risk factor for the development of eating disorders. Research from Asia suggests that the association is not unique to traditionally western cultures. Based on scale of social media usage amongst young people, this issue is worthy of attention as an emerging global public health issue.
Disrespect and abuse in maternity care in a low-resource setting in Tanzania: Provider’s perspectives of practice
Authors: Mwasha Loveluck K. , Kisaka Lucy M. , Pallangyo Eunice S. 
Published: March 2023

Background
Globally, women experience disrespectful and abusive care from maternity healthcare providers at health facilities, committed intentionally or unintentionally, particularly during labor and delivery. Disrespectful care affects women’s childbirth experience and birth outcomes.

Methods
This study used a descriptive qualitative design to obtain thick and rich data on disrespect and abuse in maternity care in a low-resource setting in Tanzania. Three days workshop was conducted at the Aga Khan University comprising maternity healthcare providers from diverse settings. The workshop was designed based on the existing evidence and anecdotal data and inspired by the authors’ experiences of disrespectful and abusive care (stereotyping clients, not listening to client’s/relatives’ concerns, unconsented care) as a client, relative, or observant of colleagues. The targeted audience was maternity healthcare providers from public and private health facilities in the Dar es Salaam region. Data collection encompassed individual responses (reflection of practice) obtained by individuals, anonymously written reflections of practice, and compiled notes from group discussions. Data were analysed thematically guided by six steps described by Braun and Clerk.

Results
A total of 80 maternity healthcare providers participated in the workshop from various health facilities, including dispensaries (n = 25), health centres (n = 2), and hospitals (n = 3) located in semi-urban Dar es Salaam.
Four main themes were identified from the data: Physical and verbal abuse; Lack of professional ethics and integrity; Vulnerable working environment; Abuse and disrespect to care providers. In addition, several sub-themes were identified within these themes: Harsh and abusive language; Beating/slapping/pinching of the mother in labor; notably, Junior midwives also disrespected and abused women; Lack of privacy and confidentiality; Poor communication; No consent for maternity healthcare procedures; Lack of courtesy and poor interpersonal skills; and, negligence of care and woman’s needs.

Conclusion
The actions of disrespect and abuse are alarming in practice and are associated with ignorance of fundamental human rights by both providers and recipients of services. Conducting workshops seems a useful approach to revealing disrespect and abuse deep-rooted in practice and provides an opportunity to rectify the problem with providers. A more extensive interventional study will be crucial to address the widespread actions of disrespect and abuse.
Secondary Sclerosing Cholangitis After Emphysematous Cholecystitis
Authors: Takahashi Koji , Ohyama Hiroshi , Takiguchi Yuichi , Sekine Yu , Toyama Shodai , Yamada Nana , Sugihara Chihei , Kan Motoyasu , Ouchi Mayu , Nagashima Hiroki , Iino Yotaro , Kusakabe Yuko , Okitsu Kohichiroh , Ohno Izumi , Kato Naoya 
Published: March 2023

ABSTRACT
A 64-year-old woman was diagnosed with emphysematous cholecystitis. An open cholecystectomy was performed immediately. After the cholecystectomy, jaundice and multiple bile duct strictures that were not present preoperatively appeared. The patient was diagnosed with sclerosing cholangitis secondary to emphysematous cholecystitis. Endoscopic biliary stenting and endoscopic biliary balloon dilatation were performed. However, jaundice did not improve. She developed candidemia 75 days after cholecystectomy. The patient died of multiple organ failures 92 days after cholecystectomy. Although rare, secondary sclerosing cholangitis occurred after emphysematous cholecystitis, and endoscopic treatment was ineffective in this case.
Trends and forecasted rates of adverse childhood experiences among adults in the United States: an analysis of the Behavioral Risk Factor Surveillance System
Authors: Hartwell Micah , Hendrix-Dicken Amy , Terry Rachel , Schiffmacher Sadie , Conway Lauren , Croff Julie M. 
Published: March 2023

Abstract

Context
Many studies have shown increases in negative social aspects in the United States that may increase the likelihood of a child experiencing adversity. These rising trends include household dysfunction, poor mental health and substance use, crime rates, and incarceration. Additionally, the pathway of adverse childhood experiences (ACEs) may also perpetuate intergenerational trauma.

Objectives
Given these increased trends, our objective was to determine the mean ACEs reported among adults by year of birth to assess trends of ACEs over time.

Methods
To assess ACEs trends in the United States, we utilized data from the 2020 Behavioral Risk Factor Surveillance System (BRFSS), a nationally representative survey. We summed individuals’ reported ACEs and then calculated the mean ACE score within age cohorts (in 1-year increments) by year of birth. We utilized an auto-regressive integrated moving average (ARIMA) model to forecast mean ACEs through 2030.

Results
Respondents to the ACEs module (n=116,378) represented 63,076,717 adults in the United States, with an average age cohort of 1715 individuals. The mean reported ACEs among individuals 80 years or older (born in or before 1940) was 0.79, while the highest mean ACEs (2.74) were reported among the cohort born in 1998—an average increase of 0.022 ACEs per year. The ARIMA model forecasted that individuals born in 2018 will, on average, surpass a cumulative of three ACEs.

Conclusions
Given the connection of ACEs to poor health outcomes and quality of life, this trend is alarming and provides evidence for the necessity of child maltreatment prevention. Multigenerational trauma-informed care and education are warranted for individuals with ACEs and may even prevent the cycle from recurring.
On-chip mode-selective manipulation based on the modal-field redistribution assisted with subwavelength grating structures
Authors: Yi Xiaolin , Li Chenlei , Zhao Weike , Zhang Long , Shi Yaocheng , Dai Daoxin 
Published: March 2023

Abstract
Efficient mode-selective manipulation in multimode photonics has drawn much attention as a key technology for realizing scalable and flexible mode-division multiplexing (MDM) systems. A mode-selective manipulation scheme based on the modal-field redistribution assisted with subwavelength grating (SWG) structures is proposed and demonstrated for the first time. In particular, the proposed scheme focuses on manipulating the coupling coefficient κ as well as the ratio δ/κ for different mode channels. The SWG structures are used to engineer the refractive-index profile and redistribute the modal field distributions in the multimode bus waveguide, so that different modes are localized in different local regions. In this way, the undesired mode coupling can be suppressed significantly while the desired mode coupling can be enhanced. With such mode manipulation scheme, the fundamental and higher-order mode channels in the bus waveguide can be added/dropped independently and freely. As a proof of concept, a three-channel mode-selective add-drop coupler utilizing the proposed scheme is fabricated and demonstrated experimentally on silicon. The fabricated devices show low excess losses ranging from 0.1 to 1.9 dB over a wavelength range of 70 nm. The inter-mode crosstalks are lower than −19.4 dB in the wavelength range of 1525–1600 nm. The crosstalks for the drop and through ports (i.e., the residual power) are suppressed to be as low as −18 ∼ −30 dB in the wavelength range of ∼60 nm with the assistance of an additional coupler in cascade for performance improvement. The present concept of manipulating the evanescent coupling of the mode-channels paves the way for designing multimode silicon photonic devices with flexible mode-selective manipulation for MDM systems.
Crystal structure of bis(tetrapropylammonium) terephthalate – 1-(diaminomethylene)thiourea – water (1/2/4) C18H40N5O4S
Authors: Li Mengfei , Geng Fangfang , Zhu Honglei 
Published: March 2023

Abstract
C18H40N5O4S, monoclinic, P21/n (no. 14), a = 8.4254(9) Å, b = 8.4254(9) Å, c = 16.1470(17) Å, β = 98.302(2)°, V = 2411.9(4) Å3, Z = 4, R
gt(F) = 0.0409, wR
ref(F
2) = 0.1162, T = 296(2) K.
Crystal structure of tris(2,2′-bipyridine-κ2
N,N′)iron(II) triiodide – dichloromethane (2/1), C61H50Cl2Fe2I12N12
Authors: Cui Chuanguo , Zhang Jinxiao , Xiao Zhiyin 
Published: March 2023

Abstract
C61H50Cl2Fe2I12N12, orthorhombic, Pbcn (no. 60), a = 13.0247(4) Å, b = 17.0204(5) Å, c = 34.1475(9) Å, β = 90, V = 7570.0(4) Å3, Z = 4, Rgt
(F) = 0.0694, wRref
(F
2) = 0.1605, T = 293(2) K.
How Dark Is It? An Investigation of Dark Money Operations in U.S. Nonprofit Political Advocacy Organizations
Authors: Irvin Renée A. 
Published: March 2023

Abstract
Claims of dark money influence on U.S. political activity are heard from both left- and right-leaning media, both accusing the other side of undue influence from high net worth political donors on American politics. This article explores the issues of donor control, transparency, and publicness of economic policy advocacy organizations. The study focuses on social welfare nonprofit organizations active in economic policy advocacy, utilizing tax filings to compose an index of transparency based on observed characteristics such as; website verbiage, board size, staffing, fundraising spending, relations to other organizations, and other indicators. All of these variables measure legal behavior, yet as L.H. Mayer describes, some organizations appear to be stretching the boundaries of the rules so egregiously as to be in violation of legal rules, with “little fear of negative consequences” (2018, 194). Organizational tactics can reflect a disinterest in public engagement, or worse, a deliberate attempt to keep the organization’s operations opaque. It is impossible to observe, with current policy, the identity of the donors. Given an index as proposed in this article, however, observers can rank organizations on a scale indicating transparent or opaque characteristics.
Interlocking corporate and policy networks in financial services: Paris-London relations post Brexit
Authors: Hall Sarah , Heneghan Martin 
Published: March 2023

AbstractThis paper examines the impacts of Brexit as an external shock to European financial centre relations. In particular, it studies the changing nature of Paris-London financial relations post Brexit. Early on in the Brexit process, Paris was not understood as the most likely European centre to benefit from Brexit given its tax regime and high office costs. However, our analysis shows that through policy and corporate network change, it has been one of the major beneficiaries. In making this argument, the paper develops a sympathetic critique of work on global cities that has tended to emphasise corporate networks without fully situating them within their political landscapes. We argue that bringing work in economic geography into closer dialogue with work in international political economy offers one fruitful way of addressing this oversight and, in turn, better understanding how inter-city relations respond to external shocks.
The United States Sentencing Commission, Compassionate Release, and Judicial Discretion
Authors: Price Mary 
Published: March 2023

The Sentencing Commission is meeting for the first time in three years to promulgate guideline amendments. This amendment cycle promises to be among the Commission’s most consequential. Among its tasks, the agency must update USSG 1B1.13, the policy statement that governs reduction of sentence for “extraordinary and compelling reasons.” So-called “compassionate release” has taken on new significance since Congress amended the authorizing statute in the First Step Act of 2018. Because the Commission had no quorum at the time and for several years after it has been unable to amend the guideline to conform to changes made by the FSA. Creative litigation has transformed compassionate release from the last resort for incarcerated people who were aging, debilitated, or dying to one used for a variety of situations deemed extraordinary and compelling by federal courts. These include grants based on reasons ranging from vulnerability to COVID all the way to the injustice of continued incarceration of people serving sentences the FSA lowered but did not make retroactive. Confronting the Commission is the question of whether and to what extent it might cabin the discretion judges have been exercising to recognize various grounds for compassionate release, including intervening changes in the law that make the sentence inequitable.
In this article, the author traces the history of compassionate release, discusses the transformation of its use since passage of the FSA, explores the various proposals the Commission has presented for comment, and presents the choices through the lens of one incarcerated person’s experience.
ASO targeting RBM3 temperature‐controlled poison exon splicing prevents neurodegeneration in vivo
Authors: Preußner Marco , Smith Heather L , Hughes Daniel , Zhang Min , Emmerichs Ann‐Kathrin , Scalzitti Silvia , Peretti Diego , Swinden Dean , Neumann Alexander , Haltenhof Tom , Mallucci Giovanna R , Heyd Florian 
Published: March 2023

AbstractNeurodegenerative diseases are increasingly prevalent in the aging population, yet no disease‐modifying treatments are currently available. Increasing the expression of the cold‐shock protein RBM3 through therapeutic hypothermia is remarkably neuroprotective. However, systemic cooling poses a health risk, strongly limiting its clinical application. Selective upregulation of RBM3 at normothermia thus holds immense therapeutic potential. Here we identify a poison exon within the RBM3 gene that is solely responsible for its cold‐induced expression. Genetic removal or antisense oligonucleotide (ASO)‐mediated manipulation of this exon yields high RBM3 levels independent of cooling. Notably, a single administration of ASO to exclude the poison exon, using FDA‐approved chemistry, results in long‐lasting increased RBM3 expression in mouse brains. In prion‐diseased mice, this treatment leads to remarkable neuroprotection, with prevention of neuronal loss and spongiosis despite high levels of disease‐associated prion protein. Our promising results in mice support the possibility that RBM3‐inducing ASOs might also deliver neuroprotection in humans in conditions ranging from acute brain injury to Alzheimer's disease.