bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recent Advances in the Multistep Continuous Preparation of APIs and Fine Chemicals
Authors: de Castro Pedro P. , Batista Gabriel M.F. , Amarante Giovanni W. , Brocksom Timothy J. , de Oliveira Kleber T. 
Published: April 2023

Abstract:
Over the last two decades, with the advent of continuous flow technologies, continuous processes have emerged as a major area in organic synthesis. In this context, continuous flow proce-sses have been increasing in the preparation of Active Pharmaceutical Ingredients (APIs) and fine chemicals, such as complex synthetic intermediates, agrochemicals, and fragrances. Thus, the deve-lopment of multi-step protocols has attracted special interest from the academic and industrial che-mistry communities. In addition to the beneficial aspects intrinsically associated with continuous processes (e.g., waste reduction, optimal heat transfer, improved safety, and the possibility to work under harsh reaction conditions and with more dangerous reagents), these protocols also allow a ra-pid increase in molecular complexity. Moreover, in telescoped multi-step processes, isolation and purification steps are generally avoided or, if necessary, carried out in-line, presenting an important economy of time, solvents, reagents, and labor. Last, important synthetic strategies such as photo-chemical and electrochemical reactions are compatible with flow processes and are delivering rele-vant advances to the synthetic approaches. In this review, a general overview of the fundamentals of continuous flow processes is presented. Recent examples of multi-step continuous processes for the preparation of fine chemicals, including telescoped and end-to-end processes, are discussed, poin-ting out the possible advantages and/or limitations of each of these methodologies.
Clinical Characteristics and Risk Factors of Polymyositis and Dermatomyositis
Combined with Interstitial Lung Disease in Patients Residing in
the Northeast Sichuan Province of China
Authors: Li Tao , Tang Zi-Yi , Zhang Quan-Bo , Xiao Fan-Ni , Jian Gui-Lin , Xie Yan , Guo Jian-Wei , Qing Yu-Feng 
Published: April 2023

Background::
Polymyositis (PM) and dermatomyositis (DM) are non-suppurative and autoimmune inflammatory diseases of striated muscle. Interstitial lung disease (ILD) is a group of heterogeneous diseases that mainly involve the pulmonary interstitium, alveoli, and/or bronchioles, also known as diffuse parenchymal lung disease (DPLD). A significant cause of death in persons with polymyositis (PM) and dermatomyositis (DM) is concurrent interstitial lung disease (ILD). However, research on the clinical characteristics and associated influencing factors of PM/DM combined with ILD (PM/DM-ILD) is currently scarce in China.

Objective::
The study aimed to probe the clinical features and risk factors of PM/DM-ILD.

Methods::
The data of 130 patients with PM/DM were gathered. General medical status, clinical symptoms, laboratory parameters, high-resolution CT, therapeutic outcomes, and prognoses were retrospectively reviewed in patients with PM/DM with (ILD group) and without (NILD) ILD.

Results::
The age of the ILD group (n=65) was more than the NILD group (n=65), and the differ-ence was statistically significant; there were no significant between-group variations in the PM/DM ratio, sex, or duration of the disease. The initial symptoms were arthritis and respiratory symptoms in the ILD group, and myasthenia symptoms in the NILD group. Incidences of Raynaud’s phenom-enon, dry cough, expectoration, dyspnea on exertion, arthritis, fever, total globulin (GLOB), eryth-rocyte sedimentation rate (ESR), and anti-Jo-1 antibody rate were higher for ILD; however, albumin (ALB), creatine kinase aspartate aminotransferase activity ratio (CK/AST) and CK levels were sig-nificantly lower in the ILD group. Bivariate logistic regression analysis showed age, dry cough, ar-thritis, dyspnea on exertion, anti-Jo-1 antibody, and elevated GLOB to be independent risk factors for ILD among patients with PM/DM.

Conclusion::
Advanced age, dry cough, arthritis, dyspnea on exertion, anti-Jo-1 antibody positivity, and elevated GLOB level are risk factors for PM/DM-ILD. This information could be utilized to carefully monitor changing lung function in these patients.
Effect of Vitamin D on Retinoblastoma Protein in Prediabetic Individuals
Authors: Hardatt Dakshita , Devi Manju , Vyas Sonal , Singh Gurvinder , Jain Jyoti , Gupta Sumeet , Dhanawat Meenakshi 
Published: April 2023

Abstract:
About 50.8 million people were diagnosed with diabetes in 2011; the count has increased
by 10 million in the last five years. Type-1 diabetes could occur at any age, but predominantly
in children and young adults. The risk of developing type II diabetes mellitus in the offspring
of parents with DM II is 40% if one parent has DM II and approaches 70% if both parents
have DM II. The process of developing diabetes from normal glucose tolerance is continuous, with
insulin resistance being the first stage. As prediabetes progresses slowly to DM II, it may take approximately
15-20 years for an individual to become diabetic. This progression can be prevented or
delayed by taking some precautions and making some lifestyle amendments, e.g., reducing weight
by 5-7% of total body weight if obese, etc. Retinoblastoma protein is one of the pocket proteins
that act as crucial gatekeepers during the G1/S transition in the cell cycle. A loss or defect in single-
cell cycle activators (especially CDK4 and CDK6) leads to cell failure. In diabetic or stress
conditions, p53 becomes a transcription factor, resulting in the transactivation of CKIs, which leads
to cell cycle arrest, cell senescence, or cell apoptosis. Vitamin D affects insulin sensitivity by increasing
insulin receptors or the sensitivity of insulin receptors to insulin. It also affects peroxisome
proliferator-activated receptors (PPAR) and extracellular calcium. These influence both insulin
resistance and secretion mechanisms, undertaking the pathogenesis of type II diabetes. The
study confines a marked decrement in the levels of random and fasting blood glucose levels upon
regular vitamin D intake, along with a significant elevation of retinoblastoma protein levels in the
circulatory system. The most critical risk factor for the occurrence of the condition came out to be
family history, showing that patients with first-degree relatives with diabetes are more susceptible.
Factors such as physical inactivity or comorbid conditions further aggravate the risk of developing
the disease. The increase in pRB levels caused by vitamin D therapy in prediabetic patients directly
influences blood glucose levels. pRB is supposed to play a role in maintaining blood sugar levels.
The results of this study could be used for further studies to evaluate the role of vitamin D and pRB
in regeneration therapy for beta cells in prediabetics.
Incorporating Antimicrobial Activity During Synthesis of New Acid-Azo
Dyes: Thermal Stability and Application on Various Fabrics
Authors: Sarwar Ambreen , Jabbar Abdul , Riaz Saadia , Parveen Samina , Sagheer Shafia , Choudhary Muhammad Iqbal 
Published: April 2023

Background::
Textile materials are susceptible to microbial attack as they provide suitable conditions for their growth. The microbes grow with normal body secretions on garments. These microbes are responsible for the weakening, brittleness, and discoloration of the substrate. Furthermore, they cause many health issues to the wearer, including dermal infection, bad odour etc. They threaten the human health as well as create tenderness in fabric.

Objectives::
Usually, antimicrobial textiles are prepared by applying antimicrobial finishes after dyeing, which is an expensive approach. Concerning these adversities, in the present study, a series of antimicrobial acid-azo dyes have been synthesized by incorporating antimicrobial sulphonamide moiety into the dye molecules during its synthesis.

Methods::
A commercially available sulphonamide-based compound, sulfadimidine Na-salt was used as a diazonium component and coupled with different aromatic amines to get desired dye molecules. Since dyeing and finishing are two separate energy-intensive processes, in the current research work, an approach to combine both processes in one step has been adopted that would be economical, time-saving, and environment friendly. Structures of the resultant dye molecules have been confirmed using different spectral techniques such as Mass spectrometry, 1H-NMR spectroscopy, FT-IR, and UV-Visible spectroscopy.

Results::
Thermal stability of the synthesized dyes was also determined. These dyes have been applied to wool and nylon-6 fabrics. Their various fastness properties were examined using ISO standard methods.

Conclusion::
All the compounds exhibited good to excellent fastness properties. The synthesized dyes and the dyed fabrics were screened biologically against Staphylococcus aureus ATCC 6538 and Escherichia coli ATCC 10536, resulting in significant antibacterial activities.
Identification of Essential Genes and Drug Discovery in Bladder Cancer
and Inflammatory Bowel Disease via Text Mining and Bioinformatics
Analysis
Authors: Zheng Qingyuan , Guo Liantao , Yang Rui , Chen Zhiyuan , Liu Xiuheng 
Published: April 2023

Background:
Bladder cancer (BCa) is the most common malignancy of the urinary
system. Inflammation is critical in the occurrence and development of BCa. The purpose of this
study was to identify key genes and pathways of inflammatory bowel disease in BCa through text
mining technology and bioinformatics technology and to explore potential therapeutic drugs for
BCa.

Methods:
Genes associated with BCa and Crohn's disease (CD) were detected using the text mining
tool GenClip3, and analyzed using Gene Ontology (GO) and the Kyoto Encyclopedia of
Genes and Genomes (KEGG). A protein-protein interaction (PPI) network was constructed by
STRING and visualized in Cytoscape, and modular analysis was performed using the Molecular
Complex Detection plugin (MCODE). Finally, the genes clustered in the first two modules were
selected as core genes, and the drug-gene interaction database was used to discover potential therapeutic
drugs.

Results:
We identified 796 genes shared by "Bladder cancer" and "Crohn's disease" by text mining.
Gene function enrichment analysis yielded 18 enriched GO terms and the 6 most relevant
KEGG pathways. A PPI network with 758 nodes and 4014 edges was constructed, and 20 gene
modules were obtained using MCODE. We selected the top two gene clusters as core candidate
genes. We found that 3 out of 55 selected core genes could be targeted by 26 existing drugs.

Conclusions:
The results indicated that CXCL12, FGF2 and FSCN1 are potential key genes involved
in CD with BCa. Additionally, 26 drugs were identified as potential therapeutics for BCa
treatment and management.
A Complete Sojourn of Current Trends in Gastro-retentive Drug Delivery System: Recent Advances and Patent Survey
Authors: Dey Abhisek , Singh Amrinder , Kurmi Balak Das , Singh Dilpreet 
Published: April 2023

Abstract:The current work aims to provide a complete sojourn on gastro-retentive drug delivery system (GRDDS) along with formulation methods, polymer selection, and in vitro/ in vivo challenges with finished dosage forms. Ideally, a biopharmaceutical-hindered drug has a rapid clearance and erratic bioavailability due to its low aqueous solubility and permeability. Additionally, it also suffers from high first-pass metabolism and pre-systemic gut wall clearance. Gastro-retentive drug delivery systems have become an emerging technology where newer methodologies and scientific approaches have been used to provide the controlled release of drugs and provide a protective mechanism in the stomach. By the virtue of utilizing GRDDS as a dosage form, these formulations increase Gastroretention time (GRT) which prolongs the controlled release of the drug in the dosage form. GRDDS contribute to increased drug bioavailability and targeting at a site of action, which enhances therapeutic action and offers significant patient compliance. Furthermore, the present work also highlighted the critical role of polymers in favoring drug retention across GIT with the mechanism of gastro-retention and recommended concentration ranges. The emerging technology is also highlighted by the approved drug products and patented formulations in the recent decade which is depicted in a justified manner. GRDDS formulations have demonstrated clinical efficacy, which is supported by a compilation of patents for cutting-edge innovations in dosage forms that can be held in the stomach for an extended period of time.
Telemedicine-Based Management of Oral Anticoagulation Therapy: Systematic Review and Meta-analysis
Authors: Braga Ferreira Letícia , Lanna de Almeida Rodrigo , Arantes Alair , Abdulazeem Hebatullah , Weerasekara Ishanka , Ferreira Leticia Santos Dias Norberto , Fonseca de Almeida Messias Luana , Siuves Ferreira Couto Luciana , Parreiras Martins Maria Auxiliadora , Suelen Antunes Núbia , Fonseca Cândido Raissa Carolina , Rosa Ferreira Samuel , Guerra Pezzini Assis Tati , Marques Pedroso Thais , Boersma Eric , Ribeiro Antonio , Marcolino Milena Soriano 
Published: April 2023

Background
Oral anticoagulation is the cornerstone treatment of several diseases. Its management is often challenging, and different telemedicine strategies have been implemented to support it.

Objective
The aim of the study is to systematically review the evidence on the impact of telemedicine-based oral anticoagulation management compared to usual care on thromboembolic and bleeding events.

Methods
Randomized controlled trials were searched in 5 databases from inception to September 2021. Two independent reviewers performed study selection and data extraction. Total thromboembolic events, major bleeding, mortality, and time in therapeutic range were assessed. Results were pooled using random effect models.

Results
In total, 25 randomized controlled trials were included (n=25,746 patients) and classified as moderate to high risk of bias by the Cochrane tool. Telemedicine resulted in lower rates of thromboembolic events, though not statistically significant (n=13 studies, relative risk [RR] 0.75, 95% CI 0.53-1.07; I2=42%), comparable rates of major bleeding (n=11 studies, RR 0.94, 95% CI 0.82-1.07; I2=0%) and mortality (n=12 studies, RR 0.96, 95% CI 0.78-1.20; I2=11%), and an improved time in therapeutic range (n=16 studies, mean difference 3.38, 95% CI 1.12-5.65; I2=90%). In the subgroup of the multitasking intervention, telemedicine resulted in an important reduction of thromboembolic events (RR 0.20, 95% CI 0.08-0.48).

Conclusions
Telemedicine-based oral anticoagulation management resulted in similar rates of major bleeding and mortality, a trend for fewer thromboembolic events, and better anticoagulation quality compared to standard care. Given the potential benefits of telemedicine-based care, such as greater access to remote populations or people with ambulatory restrictions, these findings may encourage further implementation of eHealth strategies for anticoagulation management, particularly as part of multifaceted interventions for integrated care of chronic diseases. Meanwhile, researchers should develop higher-quality evidence focusing on hard clinical outcomes, cost-effectiveness, and quality of life.

Trial Registration
PROSPERO International Prospective Register of Systematic Reviews CRD42020159208; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=159208
KETERLIBATAN EMOSI SEBAGAI DASAR SUKSESI: STUDI PADA PERUSAHAAN KELUARGA MILIK PEREMPUAN
Authors: Kusuma Gregoria Rosarheina 
Published: April 2023

This study aims to examine the emotional involvement in the succession process of women-owned family companies. This qualitative research with a phenomenological approach examines 4 women-owned family companies that have succeeded in succession, and data were collected by semi-structured interviews. Research credibility is maintained by means of triangulation, member checking, and making descriptions of research results rich and concise. The results of the study indicate that there is an emotional bond between the owner and his company which is reflected in the company's basic values, the company's vision for the future, and the desire for the company to generate generations. In the succession process, this emotional bond is manifested in a distinctive way to select, train, and prepare children as heirs of the company. These typical ways support a succession process that feels "smooth" and minimally conflicted, where the successor has mastered the knowledge and skills needed to lead the company and feels easy and comfortable to accept the transfer.
Keywords: succession; emotion; family company; women-owned family company; female entrepreneur.
Penelitian ini bertujuan untuk mengkaji keterlibatan emosi dalam proses suksesi perusahaan keluarga milik perempuan. Penelitian kualitatif dengan pendekatan fenomenologi ini meneliti 4 perusahaan keluarga milik perempuan yang telah berhasil melakukan suksesi, dan data dikumpulkan dengan wawancara semi terstruktur. Kredibilitas penelitian dijaga dengan cara triangulasi, member checking, dan membuat deskripsi hasil penelitian dengan kaya dan padat. Hasil penelitian menunjukkan adanya ikatan emosional antara pemilik dengan perusahaannya yang tercermin dalam nilai-nilai dasar perusahaan, visi perusahaan ke depan serta adanya keinginan agar perusahaan dapat menggenerasi. Dalam proses suksesi, ikatan emosional ini terwujud dalam cara yang khas untuk memilih, melatih serta mempersiapkan anak sebagai pewaris perusahaan. Cara-cara yang khas tersebut mendukung terjadinya proses suksesi yang dirasa ”halus” dan minim konflik, di mana suksesor telah menguasai pengetahuan dan keterampilan yang dibutuhkan untuk memimpin perusahaan dan merasa mudah serta nyaman untuk menerima transfer.
Kata kunci: suksesi; emosi; perusahaan keluarga; perusahaan keluarga milik perempuan; pengusaha perempuan.
A Critical Evaluation of Mobile Court Act 2009: How Mobile Court Demolishes Separation of Judiciary and Other Constitutional Principles of Bangladesh
Authors: Tamanna Anwara Begum 
Published: April 2023

Separation of power is a key for the independence of people. Though this principle has not been accepted by the framer of constitution of Bangladesh. Nevertheless separation of judiciary is adopted by the maker of constitution. Judiciary is a place to restore the claims of the people of a country. But it cannot make people happy if it is not independent. The principle of separation of judiciary has been violated by various approaches. One of them is Mobile court. Mobile court is a forum which goes to the threshold of public in order to give prompt relief. It has reversed the general rules of judicial system. Though this fact claims appreciation for delivering justice. But it has been criticized as it is conducted by executive. This paper shows how mobile court infringed article 22 of constitution. It also shows how other principle of constitution is violated. Finally it gives some suggestion for the improvement of the situation.
Komunikasi Pendek: Waspadai Penggunaan Beta Agonis 2 pada Peternakan Babi untuk Menjamin Kualitas Bahan Asal Hewan
Authors: Tenaya I Wayan Masa 
Published: April 2023

Dari aspek Ilmu Kesehatan Masyarakat Veteriner, bahan asal hewan yang akan dikonsumsi masyarakat harus berkualitas yang baik. Adanya kejanggalan performance phisik ternak babi yang diternakan di beberapa peternak tertentu di Bali, seperti pertumbuhan otot daging sangat menjolok dan kurang sesuai kalau dilihat dari pengaruh mutu genetik, pakan dan managemen pemeliharaan pada umumnya. Dari kejanggalan tersebut, timbul suatu dugaan adanya pemakaian Beta agonis 2 yang sudah dilarang pemerintah, yang mungkin masih diberikan kepada ternak babi. Adanya persaingan bisnis untuk meraup keuntungan yang tinggi, tanpa menghiraukan kesehatan konsumen adalah tindakan melanggar undang-undang. Oleh karena itu dalam tulisan ini, penulis mengajak para pemerhati kesehatan hewan dan masyakarat dalam kesatuan One Health untuk melakukan pengawasan dan tindakan yang diperlukan.
HUBUNGAN DUKUNGAN KELUARGA DENGAN KEMANDIRIAN LANSIA DALAM PEMENUHAN AKTIVITAS SEHARI-HARI
Authors: Astika Aulya Lintang Octa , Lestari Puji 
Published: April 2023

The decrease in various organ functions in the elderly leads to a decrease in the independence of the elderly in the fulfillment of daily activities. It requires the support of the family. The phenomenon found, there are elderly people with good family supports but the fulfillment of daily activities is still low. This study was to determine the relationship between family support and the independence of the elderly in fulfilling daily activities. The design of this study is descriptive correlational with a cross sectional approach. 51 respondents were taken with purposive sampling technique. The measuring instrument used is a questionnaire Perceived Social Support-Family and Lawton Instrumental Activity Everyday Living. The data obtained were analyzed using the chi square test. Most of family support is sufficient (60,8%) and the independence of the elderly in fulfilling daily activities is mostly independent (56,9%). There is a significant relationship between family support and the independence of the elderly in fulfilling daily activities with p-value of 0,046 (< 0,05).
EVALUASI PEMBELAJARAN MAHASISWA KEPERAWATAN: SEBUAH TINJAUAN
Authors: Wulandari Sarah K. , Nuryanto I Kadek 
Published: April 2023

The achievement of learning outcomes in tertiary institutions has benchmarks that must be relevant to the industrial world. Active involvement of students in the learning process and the desire to achieve competence according to learning outcomes needs to be facilitated by continuous planning and evaluation. The aim of the current study was to evaluate clinical practice learning satisfaction in nursing students. This research is a descriptive analysis with cross sectional design. The instrument used is the Educational Practices Questionnaire-C (EPQ-C) questionnaire used for self-evaluation learning evaluation variables with 22 statement items with modification. The sample of this study were 78 nursing students using a non-probability technique, namely total sampling. The results of this study indicate that the questionnaire used was reliable with Cronbach`s Alpha 0,77. The results shown respondents were in the satisfied category as much as 51,2% (40 people). The conclusion in this study is that most students express satisfaction with the clinical learning process that takes place during their education period. However, several assessment items need to get attention so that they can be used as indicators in improving the learning process for students, especially nursing. So that learning satisfaction becomes better and competence achievement is more optimal.
Kepemilikan Institusional, Kepemilikan Asing dan Pengungkapan Corporate Social Responsibility
Authors: Mahadewi Ida Ayu Sinta , Budiasih I Gusti Ayu Nyoman 
Published: April 2023

This study aims to examine the effect of institutional ownership and foreign ownership on CSR disclosure. Communicating CSR information can be done by disclosing CSR. The research was conducted at service companies in the property, real estate and building construction sectors listed on the Indonesia Stock Exchange (IDX). The research population is 67 companies. Determining the number of samples using purposive sampling technique with three criteria and then obtained 32 samples. Data were analyzed using multiple linear regression analysis. The results show that institutional ownership has a positive effect on CSR disclosure, while foreign ownership has a negative effect on CSR disclosure. The results of this study can theoretically confirm agency theory and corporate governance.
Keywords: Corporate Social Responsibility; Institutional Ownership; Foreign Ownership