bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mitochondria‐Related Genome‐Wide Mendelian Randomization Identifies Putatively Causal Genes for Neurodegenerative Diseases
Authors: Wang Zheyi , Sun Yize , Bai Zetai , Li Mei , Kong Deyuan , Wu Guanzhao 
Published: January 2025

AbstractBackgroundMitochondrial dysfunction is increasingly recognized as a key factor in neurodegenerative diseases (NDDs), underscoring the therapeutic potential of targeting mitochondria‐related genes. This study aimed to identify novel biomarkers and drug targets for these diseases through a comprehensive analysis that integrated genome‐wide Mendelian randomization (MR) with genes associated with mitochondrial function.MethodsUsing existing publicly available genome‐wide association studies (GWAS) summary statistics and comprehensive data on 1136 mitochondria‐related genes, we initially identified a subset of genes related to mitochondrial function that exhibited significant associations with NDDs. We then conducted colocalization and summary‐data‐based Mendelian randomization (SMR) analyses using expression quantitative trait loci (eQTL) to validate the causal role of these candidate genes. Additionally, we assessed the druggability of the encoded proteins to prioritize potential therapeutic targets for further exploration.ResultsGenetically predicted levels of 10 genes were found to be significantly associated with the risk of NDDs. Elevated DMPK and LACTB2 levels were associated with increased Alzheimer's disease risk. Higher expression of NDUFAF2, BCKDK, and MALSU1, along with lower TTC19, raised Parkinson's disease risk. Higher ACLY levels were associated with both amyotrophic lateral sclerosis and multiple sclerosis (MS) risks, while decreased MCL1, TOP3A, and VWA8 levels raised MS risk. These genes primarily impact mitochondrial function and energy metabolism. Notably, several druggable protein targets identified are being explored for potential NDDs treatment.ConclusionsThis data‐driven MR study demonstrated the causal role of mitochondrial dysfunction in NDDs. Additionally, this study identified candidate genes that could serve as potential pharmacological targets for the prevention and treatment of NDDs. © 2025 International Parkinson and Movement Disorder Society.
Treatment With Full‐Spectrum Cannabidiol Oil Improved the Pathological Findings of Dystrophic Mutant Mice
Authors: Ferreira Laís Leite , Gomes Fabricio Souza , Nascimento Beatriz Godinho , Corsini Wagner , dos Reis Luis Felipe Cunha , Oliveira‐Silva João Marcos , da Silva Josie Resende Torres , da Silva Marcelo Lourenço , Gamero Angel Maurício Castro , Hermes Túlio de Almeida 
Published: January 2025

ABSTRACTIntroduction/AimsDuchenne muscular dystrophy (DMD) is caused by pathogenic variants in the DMD gene, making muscle fibers susceptible to contraction‐induced membrane damage. Given the potential beneficial action of cannabidiol (CBD), we evaluated the in vitro effect of full‐spectrum CBD oil on the viability of dystrophic muscle fibers and the in vivo effect on myopathy of the mdx mouse, a DMD model.MethodsIn vitro, dystrophic cells from the mdx mouse were treated with full‐spectrum CBD oil and assessed with cell viability and cytotoxic analyses. In vivo, fourteen‐day‐old mdx mice received 10 mg/kg/day of the full‐spectrum CBD oil for 14 days. We analyzed creatine kinase (CK) levels, liver damage markers, and histopathology of the diaphragm (DIA) and quadriceps (QUA [myonecrotic fibers with positive IgG staining, regenerated fibers/central nuclei, the minimum Feret's diameter, the fibrosis area, the inflammatory area, the presence of macrophages, and NF‐kappa B content]).ResultsIn vitro treatment with full‐spectrum CBD oil showed a dose‐dependent cytotoxic effect; however, in vivo 10 mg/kg treatment was safe and effectively improved DMD histopathological assessment parameters in DIA and QUA: reduction of central nuclei: 1.7% ± 2.0% versus 22.4% ± 5.3% and 11.1% ± 10.7% versus 32.3% ± 4.6%; reduction of IgG+ myofibers: 0.6% ± 0.7% versus 8.4% ± 1.6% and 0.9% ± 0.3% versus 7.5% ± 1.0%; increase in myofiber size: 85.2 ± 3.2 versus 64.3 ± 4.0 μm and 106.5 ± 8.6 versus 81.2 ± 4.8 μm; decrease in inflammatory area: 6.2% ± 2.7% versus 15.1% ± 2.6% and 5.3 ± 4.1 versus 17.3% ± 2.8%; reduced macrophage area: 0.05% ± 0.1% versus 10.8% ± 4.3% and 1.0% ± 0.7% versus 10.3% ± 4.9%; NF‐κB levels: 0.6% ± 0.1% versus 1.7% ± 0.2% and 1.7% ± 0.1% versus 5.2% ± 2.1%; and fibrosis: 5.6% ± 1.8% versus 12.0% ± 3.7% and 1.3% ± 0.5% versus 4.7% ± 1.5%. It also reduced serum CK.DiscussionFull‐spectrum CBD oil may represent a promising new approach to treating DMD, but its potential toxicity must be considered.
Fluxes of Courant Bracket Twisted at the Same Time by B$B$ and θ$\theta$
Authors: Davidović Ljubica , Ivanišević Ilija , Sazdović Branislav 
Published: January 2025

AbstractThe simultaneous twisting of the Courant bracket by a 2‐form and a bi‐vector is investigated, with the generalized fluxes obtained in Courant algebroid relations explored. The twisted Lie bracket is defined and it is demonstrate that the generalized ‐flux can be expressed as the field strength defined on this Lie algebroid. Similarly, it is shown that the ‐flux is a direct consequence of simultaneous twisting, which arises in the twisted Lie bracket relations between holonomic partial derivatives. The generalized flux is obtained in terms of the twisted Koszul bracket, which is identified as a quasi‐Lie algebroid bracket. The action of an exterior derivative related to the twisted Koszul bracket on a bi‐vector produces the generalized ‐flux. It is shown that the generalized ‐flux is also the twisted Schouten–Nijenhuis bracket, i.e., the natural graded bracket on multi‐vectors defined with the twisted Lie bracket.
Placing Migration: Towards More‐Than‐Relational Geographical Migration Studies
Authors: Axelsson Linn , Hedberg Charlotta 
Published: January 2025

ABSTRACTThis paper critically engages with the spatial assumptions that underpin migration studies, highlighting a shift from an absolute view of space to a relational spatial perspective, influenced by transnational and translocal migration studies. While the latter emphasises the interconnectedness of migrants across borders and the fleeting translocal links involved in the production of places, this paper argues that a timeplace perspective, which sees places as products of temporally entangled, partially inertial and plastic connectivities, material objects, and discursive practices, can contribute to overcome dichotomies between process and product in migration studies. Using the case of Åsele municipality in northern Sweden, the paper illustrates how a timeplace perspective can enrich the understanding of migration dynamics, and potentially reconcile tensions between essentialist and fluid worldviews in migration scholarship. Ultimately, it suggests that a plastic and contextual understanding of space might be the next logical step for migration studies.
Distribution Relationship of Quantum Battery Capacity
Authors: Wang Yiding , Huang Xiaofen , Zhang Tinggui 
Published: January 2025

AbstractThe distribution relationship of quantum battery capacity is investigated. First, it is proved that for two‐qubit ‐states, the sum of the subsystem battery capacities does not exceed the total system's battery capacity, and the conditions are provided under which they are equal. Then define the difference between the total system's and subsystems' battery capacities as the residual battery capacity () and show that this can be divided into coherent and incoherent components. Furthermore, it is observed that this capacity monogamy relation for quantum batteries extends to general ‐qubit states and any ‐qubit state's battery capacity distribution can be optimized to achieve capacity gain through an appropriate global unitary evolution. Specifically, for general three‐qubit states, stronger distributive relations are derived for battery capacity. Quantum batteries are believed to hold significant potential for outperforming classical counterparts in the future. These findings contribute to the development and enhancement of quantum battery theory.
Mixed Cultures for Biodegradation of Lindane: From Genome‐Based Assembly to Practical Assessment
Authors: Vu Phuong Ha , Pham Hai Hoang , Vu Tung Son , Le Anh Hien , Luu Dong Tran , Tran Trang Quynh Thi , Nguyen Yen Thi , Nguyen Thuy Thu Thi , Mai Linh Dam Thi , Bui Ha Viet Thi , Tran Hanh My , Nguyen Huy Quang , Nguyen Thao Kim Nu , Tran Anh Thuy Thi , Tran Huyen Thanh Thi , Pham Hai The 
Published: January 2025

ABSTRACTLindane, or γ‐hexachlorocyclohexane (γ‐HCH), was one of the most widely used organic pesticides in the 20th century, but has been banned worldwide due to its high toxicity and harmful effects to humans and animals. However, because of its resistance to decomposition, lindane can be persistent (with a long half‐life of up to several years in the natural environment) and can thus bioaccumulate through the food web, thereby causing serious contamination. Currently, in addition to physical–chemical methods, innovative biodegradation‐based methods for treating lindane contamination are preferred due to their sustainability and effectiveness. In this study, we explored the possibility of constructing mixed microbial cultures that could provide improved lindane degradation efficiencies, based on genome annotation, using the KEGG database and the subsequent predictions of metabolic interactions between single strains. Based on such genome‐mining results, we proposed 10 potential lindane‐degrading mixed cultures of different strain combinations and evaluated their lindane degradation performance in liquid, semi‐solid, and solid media. The results showed that several mixtures displayed higher lindane‐degrading efficiencies versus single cultures, by up to 20%–30%, in a liquid medium, although their performances were not remarkable in semi‐solid and solid media. The well‐performing mixed cultures also adapted to broader spectra of environmental conditions. We hypothesized that the central roles of two core strains (Pseudomonas putida PAM66 and a Streptommyces katrae A119) and the complicated interactions among the component strains might be attributed to the performances of the mixtures. Overall, our study supports the use of constructed mixed cultures in improving biodegradation, especially to xenobiotics like lindane, and emphasizes the importance of exploiting genome‐mining techniques to design those mixtures.
Chromosome segregation errors during early embryonic development
Authors: Kyogoku Hirohisa 
Published: January 2025

AbstractBackgroundMitosis maintains a genome's genetic information in daughter cells by accurately segregating chromosomes. However, chromosome aberrations are common during early mammalian embryogenesis. Chromosomal abnormalities during the early stages of embryogenesis result in the formation of mosaic embryos, wherein cells with normal genomes coexist with cells exhibiting abnormal genomes. The precise frequency and etiology of such abnormalities remain unclear. It is postulated that these aberrations contribute to the etiology of a number of conditions, including infertility and congenital diseases such as Down's syndrome.MethodsThis review synthesizes current literature and data to elucidate the causes and implications of chromosome aberrations in early mammalian embryos. It places particular emphasis on identifying patterns of mosaicism and investigating the underlying mechanisms responsible for these abnormalities.Main FindingsThe underlying causes of chromosome abnormalities in early embryos were examined in the context of DNA replication and embryonic development.ConclusionA deeper understanding of chromosome abnormalities in early embryos could help develop new infertility treatments and advance research on cancers caused by these abnormalities. This article reviews current knowledge and gaps in understanding chromosome segregation abnormalities during embryogenesis and future directions in this field.
In Situ Anchoring Functional Molecules to Polymer Chains Through Supramolecular Interactions for a Robust and Self‐Healing Multifunctional Waterborne Polyurethane
Authors: Zhou Chen , Zhao Nana , Liu Weiqi , Hao Fukang , Han Mengjie , Yuan Jinfeng , Pan Zhicheng , Pan Mingwang 
Published: January 2025

AbstractNowadays, much attention is paid to the development of high‐performance and multifunctional materials, but it is still a great challenge to obtain polymer materials with high mechanical properties, high self‐healing properties, and multifunctionality in one. Herein, an innovative strategy is proposed to obtain a satisfactory waterborne polyurethane (PMWPU‐Bx) by in situ anchoring 3‐aminophenylboronic acid (3‐APBA) in a pyrene‐capped waterborne polyurethane (PMWPU) via supramolecular interactions. The multiple functional sites inherent in 3‐APBA can produce supramolecular interactions with groups on PMWPU, promoting the aggregation of hard domains in the polymer network, which confers the PMWPU‐Bx strength (7.9 MPa) and high modulus (243.2 MPa). Meanwhile, the dynamic natures of boronic ester bonds formed by the condensation of 3‐APBA endow PMWPU‐Bx with a high self‐healing efficiency. Additionally, PMWPU‐Bx exhibits fluorescence tunability due to the controlled π–π stacking. In this research, the strategy of anchoring functional molecules onto polymers through supramolecular interactions synchronously achieves the high performance and the multi‐functionality of waterborne polyurethanes, but also broadens their potential applications in the fields of optical anticounterfeiting and encrypted information transmission.
The Technical Subtechnical Nontechnical Vocabulary Model: Helping Students to Make Sense of Math Story Problems
Authors: Hagge Julia , Appova Aina 
Published: January 2025

AbstractDespite proficient math skills, students may struggle to make sense of and solve story problems. While educators are encouraged to promote the use of comprehension strategies, students must first understand vocabulary at all levels as they work to make sense of and solve math story problems. Language skills are a prerequisite for schema construction, which mediate the language‐related pathway to solving story problems. In this article, we examine the role of language in making sense of math story problems and discuss the types of vocabulary to consider. We provide the Technical Subtechnical Nontechnical (TSN) Vocabulary Model as an instructional planning tool to assist in supporting all students to make sense of math story problems, along with examples of how to use the tool to plan for instruction.
Decarbonization and Electrification in the Northeast: The Climate Crisis Will Foster a New Québec-United States Relationship in Electricity
Authors: Pineau Pierre-Olivier 
Published: January 2025

Abstract
Québec is a large hydropower producer that already exports significant amounts of electricity to New York and New England. While such trade has a long history, it never translated into a stronger relationship, such as common institutions or markets. This chapter argues that the climate crisis and the existing decarbonization aspirations in the Northeast could help bring closer together Québec and its U.S. neighbors, by making more salient the benefits for all of more regional collaboration. Such cooperation in energy has been discussed in regional political meetings for a long time, but words never translated into actions. Several pathways are possible, all leading to more affordable decarbonization results.
QAnon’s Influence in Québec, from Alexis Cossette-Trudel to Éric Duhaime: Signs of an Americanization of Québec's Political Culture?
Authors: Turgeon Alexandre 
Published: January 2025

Abstract
This chapter explores the American presence within social movements opposing the Québec government's health measures in response to the COVID-19 pandemic that began in 2020. This contribution illustrates that these visual, political, and symbolic borrowings (marked by the seal of QAnon and fostered by the anxiety-inducing aspect of the pandemic that has shaken everything in its path) are part of and reflect an Americanization of Québec's political culture. In doing so, this essay focuses on the contribution of Alexis Cossette-Trudel, who as a conduit and thinker for this movement in Québec, played a leading role in the dissemination and propagation of QAnon's ideas. This chapter also examines the involvement of Éric Duhaime, leader of the Conservative Party of Québec, whose use of the language and codes of the QAnon movement in the run-up to Québec’s provincial election on October 3, 2022, can be arguably best viewed as part of a deliberate political calculation and ideological positioning, whose effects could be felt eventually on the benches of the National Assembly of Québec.
Discriminating between the maxillary tuberosity and the alveolar tuberosity– a critical pictorial review
Authors: Dandoczi Carol Antonio , Rusu Mugurel Constantin , Mureşan Alexandru Nicolae , Tudose Răzvan Costin 
Published: January 2025

Abstract

Purpose
The maxillary tuberosity, a critical anatomical landmark in dentistry and maxillofacial surgery, is burdened by terminological confusion. This inconsistency hampers clinical practice and communication across disciplines.

Method
Different resources were used to argue for the necessity of standardising the terminology related to maxillary tuberosity to enhance diagnostic precision and ultimately improve patient outcomes.

Results
Most clinical and surgical studies dealing with the distal alveolar bone of the maxilla erroneously indicate it as “maxillary tuberosity”. By recognising the diverse definitions of this structure, errors and misinterpretation of studies could be reduced, and interdisciplinary collaboration could be improved. The term “alveolar tuberosity” is recommended to refer specifically to the distal end of the alveolar process of the maxilla. Anatomically, the maxillary tuberosity belongs to the body of the maxilla and forms part of the posterior wall of the maxillary sinus; therefore, it should not be located in the alveolar process.

Conclusion
Adhering to the Terminologia Anatomica will clarify the critical clinical and surgical landmarks and enhance communication in clinical and academic settings.
Timing of acute decompensated heart failure in patients with heart failure and mildly reduced ejection fraction
Authors: Steffen Henning Johann , Abel Noah , Lau Felix , Schmitt Alexander , Reinhardt Marielen , Akin Muharrem , Bertsch Thomas , Rusnak Jonas , Weidner Kathrin , Behnes Michael , Akin Ibrahim , Schupp Tobias 
Published: January 2025

Abstract
This study investigates the prognosis of acute decompensated heart failure (ADHF) on admission (i.e., primary ADHF) as compared to ADHF onset during course of hospitalization (i.e., secondary ADHF) in patients hospitalized with heart failure with mildly reduced ejection fraction (HFmrEF). Limited data regarding the prognostic impact of the timing of onset of ADHF is available. Consecutive patients with HFmrEF and ADHF were retrospectively included at one institution from 2016 to 2022. Patients with primary ADHF were compared to patients with secondary ADHF with regard to the primary endpoint all-cause mortality at 30 months. Kaplan–Meier, uni- and multivariable Cox proportional regression analyses were applied for statistics. From a total of 484 patients hospitalized with HFmrEF and ADHF, 67.98% (n = 329) were admitted with primary ADHF. Patients with secondary ADHF had higher rates of concomitant acute myocardial infarction, alongside with a higher extend of coronary artery disease. The risk of all-cause mortality at 30 months was not affected by the timing of ADHF (hazard ratio (HR) = 0.853; 95% confidence interval (CI) 0.653–1.115; p = 0.246). However, patients with primary ADHF were associated with a higher risk of HF-related rehospitalization at 30 months (HR = 2.513; 95% CI 1.555–4.065; p = 0.001), which was still evident after multivariable adjustment (HR = 2.347; 95% CI 1.418–3.883; p = 0.001). The timing of onset of ADHF was not associated with long-term mortality in HFmrEF, however primary ADHF was associated with a higher risk of HF-related rehospitalization.
Usefulness of serum HBV RNA levels for predicting antiviral response to entecavir treatment in patients with chronic hepatitis B
Authors: Kosaka Masanari , Fujino Hatsue , Tsuge Masataka , Yamaoka Kenji , Fujii Yasutoshi , Uchikawa Shinsuke , Ono Atsushi , Murakami Eisuke , Kawaoka Tomokazu , Miki Daiki , Hayes Clair Nelson , Kashiyama Seiya , Mokuda Sho , Yamazaki Shinichi , Oka Shiro 
Published: January 2025

Abstract

Background
Hepatitis B virus (HBV) RNA is an important serum biomarker of hepatic covalently closed circular DNA (cccDNA) transcriptional activity; however, its clinical characteristics remain unclear. This study evaluated the clinical utility of HBV RNA levels in patients with chronic hepatitis B (CHB).

Methods
We studied 87 CHB patients with serum HBV DNA levels ≥ 5.0 log IU/mL who initiated entecavir (ETV) treatment between 2000 and 2018. Serum HBV RNA levels were measured at three-time points: before ETV treatment, at 12 weeks, and at 48 weeks after starting ETV treatment. Clinical markers associated with the antiviral effects of ETV treatment were analyzed.

Results
Serum HBV RNA levels decreased in both HBeAg-positive and -negative patients during the observation period. In HBeAg-positive patients, multivariable analysis showed that lower HBV RNA levels at 48 weeks of ETV treatment were independently associated with HBeAg seroconversion. Additionally, lower baseline HBV RNA levels significantly predicted virologic response in those patients. In contrast, among HBeAg-negative patients, lower HBV core-related antigen (HBcrAg) levels and the FIB-4 index were independently associated with virologic response. In HBeAg-positive patients, those with higher baseline HBV RNA levels showed a more significant reduction in hepatitis B surface antigen levels.

Conclusion
Serum HBV RNA levels predicted HBeAg seroconversion and early HBV DNA reduction in HBeAg-positive patients, while HBcrAg was significantly associated with virologic response in HBeAg-negative patients. These findings highlight the different predictive roles of HBV RNA and HBcrAg based on HBeAg status, which may provide individualized treatment strategies.
AMPA Receptors in Synaptic Plasticity, Memory Function, and Brain Diseases
Authors: de León-López Cristina A. Muñoz , Carretero-Rey Marta , Khan Zafar U. 
Published: January 2025

Abstract
Tetrameric AMPA-type ionotropic glutamate receptors are primary transducers of fast excitatory synaptic transmission in the central nervous system, and their properties and abundance at the synaptic surface are crucial determinants of synaptic efficacy in neuronal communication across the brain. The induction of long-term potentiation (LTP) leads to the insertion of GluA1-containing AMPA receptors at the synaptic surface, whereas during long-term depression (LTD), these receptors are internalized into the cytoplasm of the spine. Disruptions in the trafficking of AMPA receptors to and from the synaptic surface attenuate both forms of synaptic plasticity. Homeostatic scaling up and scaling down, which are additional types of plasticity similar to LTP and LTD, are also regulated by the insertion and removal of GluA1-containing AMPA receptors from the synaptic surface. The trafficking of AMPA receptors is an intricate process assisted by various proteins. Furthermore, AMPA receptors are critical for the formation and consolidation of various types of memory, and alterations in their function are intimately associated with cognitive dysfunction in aging and several neurological and psychiatric diseases. In this review, we will provide an overview of the current understanding of how AMPA receptors regulate various forms of synaptic plasticity, their contribution to memory functions, and their role in aging and brain diseases.