bluuebunny/crossref_metadata_2025_split huggingface dataset:
MSH3: a confirmed predisposing gene for adenomatous polyposis
Authors: Villy Marie-Charlotte , Masliah-Planchon Julien , Schnitzler Anne , Delhomelle Hélène , Buecher Bruno , Filser Mathilde , Merchadou Kevin , Golmard Lisa , Melaabi Samia , Vacher Sophie , Blanluet Maud , Suybeng Voreak , Corsini Carole , Dhooge Marion , Hamzaoui Nadim , Farelly Solenne , Ait Omar Amal , Benamouzig Robert , Caumette Vincent , Bahuau Michel , Cucherousset Joël , Allory Yves , Stoppa-Lyonnet Dominique , Bieche Ivan , Colas Chrystelle 
Published: July 2023

BackgroundTheMSH3gene is part of the DNA mismatch repair system, but has never been shown to be involved in Lynch syndrome. A first report of four patients from two families, bearing biallelicMSH3germline variants, with a phenotype of attenuated colorectal adenomatous polyposis raised the question of its involvement in hereditary cancer predisposition. The patients’ tumours exhibited elevated microsatellite alterations at selected tetranucleotide repeats (EMAST), a hallmark ofMSH3deficiency.MethodsWe report five new unrelated patients withMSH3-associated polyposis. We describe their personal and familial history and study the EMAST phenotype in various normal and tumour samples, which are relevant findings based on the rarity of this polyposis subtype so far.ResultsAll patients had attenuated colorectal adenomatous polyposis, with duodenal polyposis in two cases. Both women had breast carcinomas. EMAST phenotype was present at various levels in different samples of the five patients, confirming theMSH3deficiency, with a gradient of instability in polyps depending on their degree of dysplasia. The negative EMAST phenotype ruled out the diagnosis of germlineMSH3deficiency for two patients: one homozygous for a benign variant and one with a monoallelic large deletion.ConclusionThis report lends further credence to biallelicMSH3germline pathogenic variants being involved in colorectal and duodenal adenomatous polyposis. Large-scale studies may help clarify the tumour spectrum and associated risks. Ascertainment of EMAST may help with the interpretation of variants of unknown significance. We recommend addingMSH3to dedicated diagnostic gene panels.
Interventional approaches to symptomatic Tarlov cysts: a 15-year institutional experience
Authors: Tracz Jovanna , Judy Brendan F , Jiang Kelly J , Caraway Chad A , Yang Wuyang , De Macena Sobreira Nara Lygia , Khan Majid , Witham Timothy F 
Published: July 2023

BackgroundTarlov cysts are perineural collections of cerebrospinal fluid most often affecting sacral nerve roots, which may cause back pain, extremity paresthesias and weakness, bladder/bowel dysfunction, and/or sexual dysfunction. The most effective treatment of symptomatic Tarlov cysts, with options including non-surgical management, cyst aspiration and injection of fibrin glue, cyst fenestration, and nerve root imbrication, is debated.MethodsRetrospective chart review was conducted for 220 patients with Tarlov cysts seen at our institution between 2006 and 2021. Logistic regression analysis was conducted to determine the association between treatment modality, patient characteristics, and clinical outcome.ResultsSeventy-two (43.1%) patients with symptomatic Tarlov cysts were managed non-surgically. Of the 95 patients managed interventionally, 71 (74.7%) underwent CT-guided aspiration of the cyst with injection of fibrin glue; 17 (17.9%) underwent cyst aspiration alone; 5 (5.3%) underwent blood patching; and 2 (2.1%) underwent more than one of the aforementioned procedures. Sixty-six percent of treated patients saw improvement in one or more symptoms, with the most improvement in patients after aspiration of cyst with injection of fibrin glue; however, this association was not statistically significant on logistic regression analysis.ConclusionAlthough the subtype of percutaneous treatment was not significantly associated with optimal or suboptimal patient outcomes, cyst aspiration both with and without injection of fibrin glue may serve as a useful diagnostic tool to (1) determine symptom etiology and (2) identify patients who might have achieved temporary improvement between the time of cyst aspiration and refill with cerebrospinal fluid as potential candidates for neurosurgical intervention of cyst fenestration and nerve root imbrication.
Nutrition services during prostate cancer androgen deprivation therapy
Authors: Baguley Brenton , Smith-Gillis Caity , Porter Judi , Kiss Nicole , Ugalde Anna 
Published: July 2023

ObjectiveDietary interventions are effective strategies to mitigate multiple side effects from androgen deprivation therapy (ADT) in prostate cancer, however the perception of, and access to, nutrition services is relatively unknown.MethodsA qualitative study using semistructured, audio recorded interviews was conducted in men with prostate cancer treated with ADT for ≥3 months. Interviews explored (1) side effects of ADT and drivers for dietary change, (2) accessibility, barriers, facilitators and use of nutrition services and (3) the preferences for nutrition service delivery. Data were coded using interpretative descriptive techniques of textual interview data, and systematically summarised to generate thematical patterns, using NVivo software.ResultsInterviews were completed of 20 men with prostate cancer treated with ADT (25.5±20.1 months). Thematic analysis revealed four overarching themes—(1)the changes from ADT: men revealed that weight gain, loss of muscle and strength from ADT were daily struggles that negatively impact body image and components of masculinity reduced; (2)strategies to take control: several dietary changes were trialled and restrictive in foods and nutrients. Barriers to accessing nutrition specialists were the cost for the service and absence of a clear referral pathway; (3)importance of nutrition knowledge: demand for specialised nutrition services with knowledge in addressing side effects from ADT; (4)diverse patients need diverse nutrition support:that includes peer or partner support, and technology supported nutrition content.ConclusionEvidence-based nutrition services are an unmet need for men treated with ADT. Future work is required to develop services that can be readily available and accessible to improve prostate cancer survivorship care.
The Roles of Green Entrepreneurial Concerns and Sustainable Management of Supply Chains Post COVID-19
Authors: Sumarliah Eli , Amrullah Nurul Iman Hima , Al-Hakeem Belal 
Published: July 2023

Scholars have begun to pay more attention to green entrepreneurial concerns (GEC) and sustainable management of supply chain (SMSC) practices, but the impact of these factors on a firm’s competitive performance (FCP) remains unclear, especially post COVID-19. Although previous studies have examined GEC and SMSC practices, they have mainly focused on assessing their effects on general firm performance, not specifically on FCP and the post-COVID-19 perspective. Therefore, this study investigates the direct links between GEC and SMSC, and between SMSC and FCP from a COVID-19 standpoint. This paper also examines the mediating effect of SMSC on the GEC–FCP relationship, and the moderating effect of digital technologies on the GEC–SMSC correlation. This study is a survey-based empirical research. The survey forms or questionnaires were distributed to 330 companies in Yemen with a response rate of 83.9%. The conceptual framework was assessed with structural equation modeling. The analysis outcomes indicate that GEC significantly affects SMSC and then FCP. The outcomes also unveil that SMSC mediates the GEC–FCP relation. Furthermore, digital technologies (e.g. artificial intelligence and big data analytics) significantly moderate the relationship between GEC and SMSC. This paper contributes to the existing literature by (i) expanding the limited findings of previous SMSC works by delivering a novel factor of GEC to boost the FCP via SMSC post the pandemic; and (ii) increasing knowledge about the effect of digital technologies on advancing SMSC and later FCP post the pandemic. Different from other academic works that have observed SMSC as a direct predicting factor for firm performance, the research offers novel insights about the capability of SMSC to mediate the relationship between GEC and FCP, and digital technologies can support the incorporation of GEC and SMSC for companies’ internal operations, particularly in the era of uncertainty such as in the post-pandemic times.
Survival From Birth Until Young Adulthood Among Individuals With Congenital Heart Defects: CH STRONG
Authors: Downing Karrie F. , Nembhard Wendy N. , Rose Charles E. , Andrews Jennifer G. , Goudie Anthony , Klewer Scott E. , Oster Matthew E. , Farr Sherry L. 
Published: July 2023

BACKGROUND:
Limited population-based information is available on long-term survival of US individuals with congenital heart defects (CHDs). Therefore, we assessed patterns in survival from birth until young adulthood (ie, 35 years of age) and associated factors among a population-based sample of US individuals with CHDs.

METHODS:
Individuals born between 1980 and 1997 with CHDs identified in 3 US birth defect surveillance systems were linked to death records through 2015 to identify those deceased and the year of their death. Kaplan-Meier survival curves, adjusted risk ratios (aRRs) for infant mortality (ie, death during the first year of life), and Cox proportional hazard ratios for survival after the first year of life (aHRs) were used to estimate the probability of survival and associated factors. Standardized mortality ratios compared infant mortality, >1-year mortality, >10-year mortality, and >20-year mortality among individuals with CHDs with general population estimates.

RESULTS:
Among 11 695 individuals with CHDs, the probability of survival to 35 years of age was 81.4% overall, 86.5% among those without co-occurring noncardiac anomalies, and 92.8% among those who survived the first year of life. Characteristics associated with both infant mortality and reduced survival after the first year of life, respectively, included severe CHDs (aRR=4.08; aHR=3.18), genetic syndromes (aRR=1.83; aHR=3.06) or other noncardiac anomalies (aRR=1.54; aHR=2.53), low birth weight (aRR=1.70; aHR=1.29), and Hispanic (aRR=1.27; aHR=1.42) or non-Hispanic Black (aRR=1.43; aHR=1.80) maternal race and ethnicity. Individuals with CHDs had higher infant mortality (standardized mortality ratio=10.17), >1-year mortality (standardized mortality ratio=3.29), and >10-year and >20-year mortality (both standardized mortality ratios ≈1.5) than the general population; however, after excluding those with noncardiac anomalies, >1-year mortality for those with nonsevere CHDs and >10-year and >20-year mortality for those with any CHD were similar to the general population.

CONCLUSIONS:
Eight in 10 individuals with CHDs born between1980 and 1997 survived to 35 years of age, with disparities by CHD severity, noncardiac anomalies, birth weight, and maternal race and ethnicity. Among individuals without noncardiac anomalies, those with nonsevere CHDs experienced similar mortality between 1 and 35 years of age as in the general population, and those with any CHD experienced similar mortality between 10 and 35 years of age as in the general population.
Olivier ou palmier ?
Authors: Valtierra Ana 
Published: July 2023

Abstract
The oldest Greek sources narrate how Leto at the time of childbirth held on to a palm tree on the island of Delos to help herself with the effort of contractions. Under this palm tree, the god Apollo was born, making it an element of sacred worship of which the ancients said that it never died. Despite the clarity of the sources in the plant identification from the 5th century BC onwards, we can observe an attempt to appropriate the sacred tree of Leto’s childbirth that is made manifest through written and visual sources. Thus, the olive tree or the image of Athena began to appear as protagonists of the myth. They began to oversee the birth of the god Apollo. This iconographic manipulation had a single purpose: to justify, through religion, the economic and political control of a key commercial centre in the Greek world.
Sustainable Internal Security in Nigeria: Any Role for International Human Rights Law?
Authors: Ibe-Ojiludu Somadina 
Published: July 2023

Abstract
Since Nigeria’s restoration to democracy in 1999, the country has never faced the same level of internal security threat as it does now, including threats from Boko Haram rebels, herdsmen and bandits. This paper argued that the problem of internal insecurity in Nigeria is a symptom of a failed state and that this can be remedied by the adoption of the concept of new approach to security in international law which essentially entails enthroning a regime of human rights protection in the country. The paper discovered that in Nigeria the number of human rights recognised in each generation of rights is not exhaustive enough. The paper further found, among other things, that Nigeria’s Fundamental Rights (Enforcement Procedure) Rule, 2009 does not give effect to internationally-recognized Rights that are uncaptured or weakly captured in Nigeria’s municipal law. The paper utilised the doctrinal methodology.
Digitalization of public sector organizations over time: The applicability of quantitative text analysis
Authors: Fossheim Karin , Lund-Tønnesen Jonas 
Published: July 2023

In recent decades, public organizations have undergone significant changes related to digitalization. These changes are the result of multiple, varying influences, such as external institutional feedback. The issue of digitalization feedback development in public organizations opens the discussion on how to study digitalization over time. In this article, we consider whether the method of quantitative text analysis can be used to observe the same administrative trends in digitalization as found using other methods and data sources in existing research. After conducting a co-occurrence analysis of documents from the Norwegian Customs Agency (NCA) over a period of 20 years, we found that the NCA's digitalization-related language changed in this period and that user feedback was the most frequently emphasized kind of external feedback. These observations are consistent with the literature, which shows that the use of co-occurrence methodology to study public administration has a positive role in future research. Points for practitioners Quantitative text analysis is an effective method to observe administrative trends. Findings of the study corroborate with previous research showing that current administrative trends emphasize collaboration between public organizations and citizen participation as central development features of digitalization of public organizations. The co-occurrence analysis has some limitations and needs to be further improved to develop theory and identify new areas of public administration digitalization.
Endometrial scratch injury in infertile women undergoing in vitro fertilization cycles: a systematic review and meta-analysis
Authors: Maged Ahmed M , El-Mazny Akmal , Lasheen Yossra , El-Nassery Noura 
Published: July 2023

Objective This study aimed to evaluate the effect of endometrial scratch injury (ESI) in infertile women undergoing in vitro fertilization (IVF). Methods We screened MEDLINE, CENTRAL, EMBASE, Web of Science, and the Cochrane Central Register from inception to April 2023 using keywords related to endometrial scratch, implantation, infertility, and IVF. We included 41 randomized, controlled trials of ESI in IVF cycles (9084 women). The primary outcomes were the clinical pregnancy, ongoing pregnancy, and live birth rates. Results The clinical pregnancy rate was reported in all 41 studies. The odds ratio (OR) for the clinical pregnancy rate had an effect estimate of 1.34 with a 95% confidence interval (CI) of 1.14 to 1.58. The live birth rate was reported in 32 studies with 8129 participants. The OR for the live birth rate had an effect estimate of 1.30 with a 95% CI of 1.06 to 1.60. The multiple pregnancy rate was reported in 21 studies with 5736 participants. The OR for the multiple pregnancy rate had an effect estimate of 1.35 with a 95% CI of 1.07 to 1.71. Conclusion ESI increases the clinical pregnancy, ongoing pregnancy, live birth, multiple pregnancy, and implantation rates in women undergoing IVF cycles.
Kinetic study of mechanical and thermal properties and thermal degradation of PVC composites based on coal gasification fine slag
Authors: Teng Yanhua , Li Kangli , Chen Long , Wang Kerui , Xue Changguo 
Published: July 2023

Coal gasification fine slag (CGFS) is a by-product of gasification process of gasification beds that pollutes the environment. To make the utilization of CGF more efficient, poly (vinyl chloride) (PVC)/CGFS composites were prepared via a melt blending process, and their mechanical and thermal properties were investigated. In order to dig deeper into the decomposition mechanism, the thermal degradation kinetics were systematically analyzed by drawing non-isothermal heat maps based on the Flynn-Wall-Ozawa, Friedman, and Kissinger model-free methods. According to the results, the properties of all tests vary significantly with CGFS content. In particular, at a the CGFS content of 20 phr, the tensile strength (tensile modulus) and flexural strength (flexural modulus) of CGFS-20 were 13.5% (47.8%) and 13.9% (41.6%) higher, respectively, than those of conventional CGFS-0 composites. However, the impact strength decreases with the increase of CGFS content. At the same time, the addition of CGFS suppresses the mass conversion rate and improves the thermal stability of PVC composites at high temperature, and the final residual mass reaches 31%, which is 12.7% higher than that of pure PVC. The kinetic analysis of thermal decomposition shows that CGFS promotes the initial degradation of the composites reduces the activation energy of the reaction, and at the same time endows them with higher thermal stability in the high-temperature phase.
Association of Argatroban Dose With Coagulation Laboratory Test in Patients on Extracorporeal Membrane Oxygenation: Activated Clotting Time vs Activated Partial Thromboplastin Time
Authors: Ahn Hyun-Young , Jung Yuju , Kim Tae Wan , Cho Yang Hyun , Yang Jeong Hoon , Chung Chi Ryang , Min Myung-Sook , Ko Ryoung-Eun 
Published: July 2023

Background: Only some studies have directly compared and analyzed the roles of activated partial thromboplastin time (aPTT) and activated clotting time (ACT) in coagulation monitoring during argatroban administration. Objectives: This study aims to assess the correlation of argatroban dose with ACT and aPTT values and to identify the optimal coagulation test for argatroban dose adjustment. Methods: We evaluated 55 patients on extracorporeal membrane oxygenation (ECMO) who received argatroban for more than 72 hours. The correlation between argatroban dose and aPTT and ACT values was evaluated. To compare argatroban dose and bleeding events according to liver dysfunction, the patients were divided into 2 groups based on alanine aminotransferase and total bilirubin. Results: Among the 55 patients, a total of 459 doses and coagulation tests were evaluated. The aPTT and ACT values showed a weak correlation with argatroban dose, with the Pearson correlation coefficients of 0.261 ( P < 0.001) and 0.194 ( P = 0.001), respectively. The agreement between the target 150 to 180 seconds for ACT and 55 to 75 seconds for aPTT was observed in 140 patients (46.1%). Twenty-four patients (43.6%) had liver dysfunction when they started argatroban. The median argatroban dose was lower in the liver dysfunction group than in the control group (0.094 mcg/kg/min vs 0.169 mcg/kg/min, P = 0.020). Difference was not observed between the 2 groups in the amount of red blood cell (0.47 vs 0.43 pack, P = 0.909) and platelet (0.60 vs 0.08 pack, P = 0.079) transfusion per day. Conclusion and Relevance: A weak correlation was observed between argatroban dose and the aPTT and ACT values. However, the agreement between aPTT and ACT was only 46.1% regarding the scope of target range. Further research is necessary to determine how to assess the optimal argatroban dose for patients administered argatroban while undergoing ECMO at the intensive care unit.
Drug extravasation with Enfortumab vedotin
Authors: Grant Christopher Ryan , de Kouchkovsky Dimitri , Kalebasty Arash Rezazadeh , Mar Nataliya 
Published: July 2023

Introduction Enfortumab vedotin is an antibody drug conjugate approved for management of pretreated locally advanced or metastatic urothelial carcinoma, which is associated with a rare risk of drug extravasation and soft tissue reactions. Case Report We report two cases of EV extravasation with subsequent development of bullae and cellulitis. Management and Outcome They were both treated for cellulitis and had conservative management without surgical intervention and were able to resume treatment with Enfortumab vedotin without subsequent adverse events. Discussion We propose that EV acts as a vesicant upon extravasation, highlight measures to prevent extravasation events, and encourage appropriate measures when dealing such as attempt of aspiration, removal of catheter, application of compresses, and thorough documentation with photographic evidence.
The Development of Totally Percutaneous Aortic Arch Repair With Inner-Branch Endografts: Experience From 2 Centers
Authors: Abisi Said , Elnemr Mohamed , Clough Rachel , Alotaibi Mohammed , Gkoutzios Panos , Modarai Bijan , Haulon Stephan 
Published: July 2023

Objective: The main objective of this study is to present the experience of 2 centers undertaking total percutaneous aortic arch-branched graft endovascular repair using combination of femoral and axillary routes. The report summarizes the procedural steps, outcomes achieved, and the benefits of this approach, which eliminates the need for direct open surgical exposure of the carotid, subclavian, or axillary arteries, thereby reducing the unnecessary associated surgical risks. Methods: Retrospectively collected data of 18 consecutive patients (15M:3F) undergoing aortic arch endovascular repair using a branched device between February 2021 and June 2022 at 2 aortic units. Six patients were treated for a residual aortic arch aneurysm following previous type A dissection with size range of (58–67 mm in diameter), 10 were treated for saccular or fusiform degenerative atheromatous aneurysm with size range of (51.5–80 mm in diameter), and 2 were treated for penetrating aortic ulcer (PAU) with size range of (50–55 mm). Technical success was defined as completion of the procedure and satisfactory placement of the bridging stent grafts (BSGs) in the supra-aortic vessels percutaneously including the brachiocephalic trunk (BCT), left common carotid artery (LCCA), and left subclavian artery (LSA) without the need for carotid, subclavian, or axillary cut down. The primary technical success was examined as primary outcome well as any other related complications and reinterventions as secondary outcomes. Results: The primary technical success with our alternative approach was achieved in all 18 cases. There was one access site complication (groin haematoma), which was managed conservatively. There was no incidence of death, stroke, or cases of paraplegia. No other immediate complications were noted. Postoperative imaging confirmed supra-aortic branch patency, with satisfactory position of the BSGs and immediate aneurysm exclusion except in 4 patients who had type 1C endoleak (Innominate: 2, LSA 2) detected on the first postoperative scan. Three of them were treated with relining/extension, and 1 spontaneously resolved after 6 weeks. Conclusions: Total percutaneous aortic arch repair with antegrade and retrograde inner-branch endografts can be performed with promising early results. Dedicated steerable sheaths and appropriate BSG would optimize the percutaneous approach for aortic arch endovascular repairs. Clinical Impact This article provides an alternative and innovative approach to improve the minimally invasive techniques in the endovascular treatment of the aortic arch conditions.