bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of climate and flooding on the phenology of Attalea phalerata (Arecaceae) in a white‐water floodplain forest of the Amazon River
Authors: Furtado Rafael Neri , Guedes Marcelino Carneiro , Dantas Adelson Rocha , Lira‐Guedes Ana Cláudia , de Toledo José Júlio 
Published: April 2023

AbstractLittle is known about the effect of the polymodal tide of the Amazon estuary on the phenology of palms. We evaluated the effect of climate/flood and biotic factors on the phenology of 80 Attalea phalerata palms over 1‐year period. Bract emission and young leaves percentage were negatively correlated to accumulated rainfall. Inflorescence and leaf production occurred mainly in the dry season. Immature fruit was positively correlated with rainfall, showing that fruit development occurs during the rainy season. The production of flowers, unripe fruit, and young leaves were positively correlated to flooding. The production of infructescence, per palm, varied from 0 to 4 and 18% of the variance was explained by variables of stem diameter, number of new leaves, altitude, and flood amplitude. The number of infructescence increased for large palms and decreased for individuals subjected to high amplitudes of flooding. These findings reveal that phenological patterns of A. phalerata are driven by seasonal variation in rainfall and flooding. Furthermore, infructescence production can be predicted by plant size and this production is sensitive to variations in flood amplitude. Alteration in rainfall and flooding due to climate change may have a negative impact on fruit production if extreme events increase in frequency.
Filling the gap: A comparative analysis of stormwater utility fees and stormwater program budgets in the Puget Sound watershed
Authors: Kinney Aimee , Evrard Raye , Bogue Kevin , James Christopher Andrew 
Published: April 2023

AbstractStormwater utility fees (SUFs) are one way to fill the growing gap between stormwater management needs and available funding. However, there is a lack of data on the overall role they play in stormwater program budgets. This paper presents an evaluation of SUFs across multiple jurisdictions to understand their contributions to overall revenue, the uses of revenue, and the extent to which ratemaking is equitable within and between jurisdictions. We compiled data on SUFs for 124 jurisdictions and program budgets for 80 jurisdictions to describe the composition of revenues and influence of municipal stormwater permit status. We also calculated SUFs applied to individual parcels in 11 jurisdictions to assess two equity outcomes: proportionality and affordability. Results indicate that SUF revenue contributed 91% of the $537.7 million in total 2019 stormwater program operational revenue. There was enormous variation among jurisdictions in annual SUF revenue per capita ($17–328), per housing unit ($42–1007), and on an area‐normalized basis (<$0.01–2.70 per ft2 impervious surface). SUFs in some cities were large enough to burden low‐income households, and the way they are billed may preclude assistance for renters. In the context of escalating costs driven in part by new regulatory requirements, these results illustrate the tension between achieving full cost recovery for stormwater services and ensuring prices are affordable for ratepayers.
Just‐below pricing in real estate: Impact by price segment and market conditions
Authors: Beck Jason , Levine Lindsay , Toma Michael 
Published: April 2023

AbstractMost prior studies of just‐below pricing have primarily focused on low‐stakes inconsequential consumer purchases, such as everyday household items. Using data from the Multiple Listing Service for the city of Savannah, Georgia, from 2006 through 2021, this study extends the more limited research on just‐below pricing for more consequential purchases, specifically housing. Beyond an examination into the general effectiveness of just‐below pricing in real estate, this study also explores the heterogeneous effects of its usage on sale price during different market conditions and in different market segments. The study shows that just‐below pricing is common in the real estate market, and it does have an impact on final sale price, working most effectively within cold real estate markets. Furthermore, it is found that just‐below pricing works best (though it is utilized least often) within low‐end price segments, while just‐below pricing can work against the seller in high‐end home price segments (though it is used most often in these segments).
Short‐term toxicity assessment of combined use of zidovudine, lamivudine and lopinavir/ritonavir in vitro and in vivo
Authors: Wen Pingjing , Ge Xianmin , Wang Yanwu , Ge Yun , Lan Guanghua , Li Bin , Qin Guangqiu , Zhu Qiuying , Chen Huanhuan , Zhu Jinhui , Qin Huiyan , Yang Hui , Luo Hailan , Gao Yuqiu , Meng Qin , Luo Liuhong , Liu Shuaifeng , Wu Xiuling , Li Shanshan , Deng Yueqin 
Published: April 2023

AbstractIntroductionA combination of zidovudine (AZT), lamivudine (3TC) and lopinavir/ritonavir (LPV/r) is one of the most effective drugs for preventing mother‐to‐child transmission (PMTCT) of HIV. However, limited information is available regarding its systemic toxicity. This study aimed to investigate its potential toxicity.MethodAn acute oral toxicity test was conducted to assess the potential acute toxicity of AZT + 3TC + LPV/r. Bacterial reverse mutation, mammalian erythrocyte micronucleus and mouse spermatogonia chromosomal aberration tests were conducted to assess its potential genotoxicity. A 28‐day feeding test was conducted to assess the potential subacute toxicity.ResultsIn mice, the LD50 of the AZT + 3TC + LPV/r mixture was greater than 2000 mg/kg body weight (BW). The rate of micronucleated polychromatic erythrocytes (PCEs) increased in a dose‐dependent manner in mice (P < 0.01). After treatment with AZT + 3TC + LPV/r for 28 days, the BW gain of male and female rats in the high‐dose group was lower than that in the control group (P < 0.05); the relative weights of the liver, kidney, spleen and brain increased (P < 0.05); and pathological abnormalities appeared in the thyroid and spleen of male and female rats in the high‐dose group. The haemoglobin (HGB) and red blood cells (RBCs) count in male and female rats decreased, but the white blood cells (WBCs) and lymphocyte apoptosis rates in male and female rats in the high‐dose group increased (P < 0.05). The total protein, albumin, cholesterol and blood glucose levels of male and female rats in the high‐dose group were significantly decreased (P < 0.05). The alanine aminotransferase (ALT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), creatinine (Cr) and blood urea nitrogen (BUN) levels of male and female rats in the medium‐ and high‐dose groups increased significantly (P < 0.05).ConclusionThe results suggest that AZT + 3TC + LPV/r may exhibit genotoxicity and subacute toxicity under experimental conditions.
The impact of group singing on children's subjective well‐being: Mixed methods research
Authors: Davies J. , Bentham S. , Duah F. 
Published: April 2023

AbstractImproving the well‐being of children has been widely discussed, yet research‐exploring strategies aimed at improving this in school‐based settings is still an emerging field of research. This mixed methods study investigated the impact of a singing intervention on the subjective well‐being of a class of 27 children aged 8–9. Over the course of 2 weeks, the class took part in 20 minutes of daily group singing with a focus on learning popular music that they chose. The sessions were delivered by a generalist primary teacher who had previously worked as a music specialist. In measuring children's subjective well‐being with emphasis on life satisfaction, the ‘Student's Life Satisfaction Scale’ was administered to the children pre‐ and post‐intervention. Of the 27 children, four (identified as disadvantaged) were interviewed as part of a focus group at the end of the intervention and questions centred around the children's opinions and enjoyment of the intervention. Results indicated that there was a much lower proportion of children with low subjective well‐being scores after the intervention than before the intervention (as measured by the SLSS questionnaire). Analysis of the Likert scale data showed a ‘medium’ (d = 0.5) effect size. Thematic analysis of the focus group revealed that singing had a broadly positive effect on the well‐being of those children, which is consistent with findings found in similar trials involving adults. Links to the theoretical framework of ‘flow’ by Csikszentmihalhi (1975) are drawn, alongside the PERMA well‐being framework model (Seligman, 2012) to help explain the effects of being engrossed in an enjoyable activity such as group singing and how this in turn can impact subjective well‐being.
Fronto‐parieto‐subthalamic activity decodes motor status in Parkinson's disease
Authors: Zhang Quan , Xie Hutao , Zhao Baotian , Yin Zixiao , Liu Yuye , Liu Defeng , Bai Yutong , Zhu Guanyu , Qin Guofan , Gan Yifei , Tian Runfa , Shi Lin , Yang Anchao , Meng Fangang , Jiang Yin , Zhang Jianguo 
Published: April 2023

AbstractAimsPatients with Parkinson's disease (PD) have various motor difficulties, including standing up, gait initiation and freezing of gait. These abnormalities are associated with cortico‐subthalamic dysfunction. We aimed to reveal the characteristics of cortico‐subthalamic activity in PD patients during different motor statuses.MethodsPotentials were recorded in the superior parietal lobule (SPL), the primary motor cortex (M1), premotor cortex (PMC), and the bilateral subthalamic nucleus (STN) in 18 freely walking patients while sitting, standing, walking, dual‐task walking, and freezing in medication “off” (Moff) and “on” (Mon) states. Different motor status activities were compared in band power, and a machine learning classifier was used to differentiate the motor statuses.ResultsSPL beta power was specifically inhibited from standing to walking, and negatively correlated with walking speed; M1 beta power reflected the degree of rigidity and was reversed by medication; XGBoost algorithm classified the five motor statuses with acceptable accuracy (68.77% in Moff, 60.58% in Mon). SPL beta power ranked highest in feature importance in both Moff and Mon states.ConclusionSPL beta power plays an essential role in walking status classification and could be a physiological biomarker for walking speed, which would aid the development of adaptive DBS.
Dermatovenerological infections
Authors: Fabri Mario , Stary Georg 
Published: April 2023

SummaryIn dermatology, infections caused by bacteria, viruses, fungi, and parasites play an important role. A large proportion of pathogen‐related infections of the skin and mucous membranes are transmitted sexually. All areas of infectious diseases and dermatovenerology are subject to highly exciting, dynamic change. This is driven by changes in the epidemiology of long‐established diseases, changes in the resistance of pathogens to anti‐infectives, recurrence of known pathogens, and the emergence of completely new pathogens. In this article, we address “resistance to anti‐infectives”, “sexually transmitted infections”, and “emerging viral infections”, three core areas of dermatovenerology that will shape the field in the years to come.
Commonly used hair oils in the Black community: a narrative review in their use to treat androgenetic alopecia
Authors: Dinkins Jewell , Iwuala Callyn , Akintilo Lisa , Ugonabo Nkem , Shapiro Jerry , Sicco Kristen Lo , Adotama Prince 
Published: April 2023

AbstractAlopecia, the loss of hair on the scalp and/or body, experienced by millions of people worldwide, can be a very debilitating condition. Specifically, androgenetic alopecia (AGA), commonly known as male or female pattern baldness, is the most common form of hair loss. In the African diaspora, oils have traditionally been used to promote hair growth and recently, the application of hair oils to the scalp for the treatment of alopecia has become increasingly popular. With the recent surge of hair oil usage in the Black community, more research is needed to determine the efficacy of hair oils, as most studies have primarily used mice subjects. This article reviews the existing literature to better understand the use of hair oils in the treatment of androgenetic alopecia. Specifically, we investigate the popular carrier oils, castor oil, and pumpkin oil as well as the essential oils, lavender, peppermint, rosemary, and tea tree oil.
False memories formation after a retention period spent asleep or awake in individuals with insomnia and good sleepers: a polysomnographic study
Authors: Malloggi Serena , Conte Francesca , De Rosa Oreste , Cellini Nicola , Gavazzi Gioele , Di Iorio Ilaria , Ficca Gianluca , Giganti Fiorenza 
Published: April 2023

SummaryFalse memories are a possible by‐product of sleep‐related memory consolidation processes when delayed testing is performed after a retention interval spent asleep. To date, the effect of a retention period spent asleep or awake on false memories formation has been addressed only in healthy subjects, while neglecting sleep‐disordered populations. In the present study, we investigated this effect in 17 insomniacs and 15 good sleepers through the Deese–Roediger–McDermott paradigm. In both groups, the encoding phase was followed by an 8‐h retention period spent in polysomnography monitored sleep (S‐condition) or wake (WK‐condition). We observed that, at free recall, insomniacs produced more false recalls in the WK‐condition compared to the S‐condition, whereas the good sleepers showed more false recalls in S‐condition than in the WK‐condition. Moreover, false recalls were higher in good sleepers than in insomniacs in the S‐condition. Both groups produced more veridical recalls in the S‐condition than in the WK‐condition. For recognition, hits (correctly recognised words) were more numerous in the S‐condition than in the WK‐condition. Our results confirm previous data on sleep‐related false memories production in good sleepers. Additionally, they show that, in insomniacs, false memories production is reduced after a sleep relative to remaining awake. These data suggest that false memories formation, reflecting adaptive memory reshaping processes going on during sleep, could occur at awakening as long as the sleep episode is efficient enough. A notable methodological issue was also identified, in that the Deese–Roediger–McDermott paradigm can be useful to investigate sleep‐dependent memory processes for false memories only when a more cognitively demanding task is employed (i.e., free‐recall instead of recognition tasks).
Prevalence and associated factors of myopia in children and adolescents in Russia: the Ural Children Eye Study
Authors: Bikbov Mukharram M. , Kazakbaeva Gyulli M. , Fakhretdinova Albina A , Tuliakova Azaliia M , Iakupova Ellina M , Panda-Jonas Songhomitra , Gilemzianova Leisan I , Garipova Liana A , Khakimov Dinar A , Islamova Liaisan I , Jonas Jost B 
Published: April 2023

BackgroundTo assess the prevalence of myopia and the distribution of ocular axial length as surrogate for myopic refractive error in school children in a population in Russia.MethodsThe Ural Children Eye Study, a school-based case–control study, was conducted in Ufa/Bashkortostan/Russia from 2019 to 2022 and included 4933 children (age: 9.7±2.6 years; range: 6.2–18.8 years). The parents underwent a detailed interview and the children an ophthalmological and general examination.ResultsPrevalence of any myopia (≤−0.50 dioptres (D)), minor myopia (−0.50 D to −1.0 D), moderate myopia (−1.01 D to −5.99 D) and high myopia (≤−6.0D) was 2187/3737 (46.2%; 95% CI 44.8% to 48.6%), 693/4737 (14.6%; 95% CI 13.6% to 15.6%), 1430/4737 (30.2%; 95% CI 28.9% to 31.5%) and 64/4737 (1.4%; 95% CI 1.0% to 1.7%), respectively. In the children aged 17+ years, prevalence of any, minor, moderate and high myopia was 170/259 (65.6%; 95% CI 59.8% to 71.5%), 130/259 (50.2%; 95% CI 44.1% to 56.3%), 28/259 (10.8%; 95% CI 7.0% to 14.6%) and 12/259 (4.6%; 95% CI 2.1% to 7.2%), respectively. After adjusting for corneal refractive power (beta: 0.09) and lens thickness (beta: −0.08), larger myopic refractive error was associated (r2=0.19) with older age (beta: 0.33), female sex (beta: 0.04), higher prevalence of maternal (beta: 0.15) and paternal (beta: 0.12) myopia, more time spent in school, with reading books or playing with the cell phone (beta: 0.05) and less total time spent outdoors (beta: 0.05). Axial length and myopic refractive error increased by 0.12 mm (95% CI 0.11 to 0.13) and −0.18 D (95% CI 0.17 to 0.20), respectively, per year of age.ConclusionsIn this ethnically mixed urban school children population from Russia, prevalence of any myopia (65.6%) and high myopia (4.6%) in children aged 17+ years was higher than in adult populations in the same region and it was lower than in East Asian school children, with similar associated factors.
Home-based exercise therapy in patients awaiting liver transplantation: protocol for an observational feasibility trial
Authors: Williams Felicity Rhian , Vallance Alice , Faulkner Thomas , Towey Jennifer , Kyte Derek , Durman Simon , Johnson Jill , Holt Andrew , Perera M Thamara , Ferguson James , Armstrong Matthew James 
Published: April 2023

IntroductionLiver disease is the third most common cause of premature mortality in the UK. Liver failure accelerates frailty, resulting in skeletal muscle atrophy, functional decline and an associated risk of liver transplant waiting list mortality. However, there is limited research investigating the impact of exercise on patient outcomes pre and post liver transplantation. The waitlist period for patients listed for liver transplantation provides a unique opportunity to provide and assess interventions such as prehabilitation.Methods and analysisThis study is a phase I observational study evaluating the feasibility of conducting a randomised control trial (RCT) investigating the use of a home-based exercise programme (HBEP) in the management of patients awaiting liver transplantation. Twenty eligible patients will be randomly selected from the Queen Elizabeth University Hospital Birmingham liver transplant waiting list. Participants will be provided with an individually tailored 12-week HBEP, including step targets and resistance exercises. Activity trackers and patient diaries will be provided to support data collection. For the initial 6 weeks, telephone support will be given to discuss compliance with the study intervention, achievement of weekly targets, and to address any queries or concerns regarding the intervention. During weeks 6–12, participants will continue the intervention without telephone support to evaluate longer term adherence to the study intervention. On completing the intervention, all participants will be invited to engage in a focus group to discuss their experiences and the feasibility of an RCT.Ethics and disseminationThe protocol is approved by the National Research Ethics Service Committee North West - Greater Manchester East and Health Research Authority (REC reference: 17/NW/0120). Recruitment into the study started in April 2017 and ended in July 2017. Follow-up of participants is ongoing and due to finish by the end of 2017. The findings of this study will be disseminated through peer-reviewed publications and international presentations. In addition, the protocol will be placed on the British Liver Trust website for public access.Trial registration numberNCT02949505; Pre-results.
Supplemental information, tables, and figures from Targeting Notch1 and IKKα Enhanced NF-κB Activation in CD133<sup>+</sup> Skin Cancer Stem Cells
Authors: Quan Xin Xin , Hawk Nga Voong , Chen Weiping , Coupar Jamie , Lee Steven K. , Petersen David W. , Meltzer Paul S. , Montemarano Andrew , Braun Martin , Chen Zhong , Van Waes Carter 
Published: April 2023

<p>1.	Supplementary Methods. 2.	References. 3.	Supplementary Table 1. Characteristics of human primary SCC samples. 4.	Supplementary Table 2. Clinical characteristics of tumor samples used in different experimental platforms. 5. Supplemental Table 3. GeneGo analysis summery of top 10 ranked signaling pathways for the stem gene signature of CD133+ hcSCC cancer stem cells. 6. Supplementary Figure 1. Clinical information of human primary cutaneous SCC samples and schematic strategy for isolation of cancer stem cell population and function assays. 7. Supplementary Figure 2. Characteristics of transcriptional profile and the top pathways of differentially expressed genes in CD133+ CSCs population. 8. Supplementary Figure 3. IKKα co-localized with CD133 expression in cSCC tissues.</p>
Supplementary Figures S1-S7; Supplementary Tables S1-S7; and Supplementary Materials and Methods from Targeting of Hematologic Malignancies with PTC299, A Novel Potent Inhibitor of Dihydroorotate Dehydrogenase with Favorable Pharmaceutical Properties
Authors: Cao Liangxian , Weetall Marla , Trotta Christopher , Cintron Katherine , Ma Jiyuan , Kim Min Jung , Furia Bansri , Romfo Charles , Graci Jason D. , Li Wencheng , Du Joshua , Sheedy Josephine , Hedrick Jean , Risher Nicole , Yeh Shirley , Qi Hongyan , Arasu Tamil , Hwang Seongwoo , Lennox William , Kong Ronald , Petruska Janet , Moon Young-Choon , Babiak John , Davis Thomas W. , Jacobson Allan , Almstead Neil G. , Branstrom Art , Colacino Joseph M. , Peltz Stuart W. 
Published: April 2023

<p>Supplementary Figures S1-S7: Supplementary Figure S1 shows chemical Synthesis and biological characterization of PTC299. Supplementary Figure S2 shows generation and characterization of PTC299-resistant HT1080 cells. Supplementary Figure 3 shows that PTC299 interacts with and inhibits the activity of DHODH. Supplementary Figure S4 shows that PTC299 inhibits de novo UMP production in both sensitive and insensitive cell lines. Supplementary Figure S5 shows that PTC299 has broad activity against leukemia in vitro and in vivo. Supplementary Figure S6 shows</p><p>that PTC299 inhibits production of VEGF protein in tumor cells more potently than does brequinar or teriflunomide. </p><p>Supplementary Figure S7 shows the comparison of GSK983 and PTC299 in pharmacokinetic study in mice; Supplementary Tables S1-S7: Supplementary Table S1 shows the information on the source of cells and when they were obtained. Supplementary Table S2 shows that the metabolism of 15N-glutamine in cells treated with PTC299 is similar to that measured in cells treated with brequinar, a known DHODH inhibitor. Supplementary Table S3 shows the summary of enriched proteins identified in PTC299 pull-down samples. Supplementary Table S4 shows PTC299 species selectivity: inhibition of de novo UMP. Supplementary Table S5 shows the preclinical safety profile of PTC299. Supplementary Table S6 shows the demographic information for patients in the NF-2 clinical trial. Supplementary Table S7 shows the differences in expression of genes related to pyrimidine nucleotide synthesis and salvage pathway in hematopoietic cancers versus solid tumors.</p>