bluuebunny/crossref_metadata_2025_split huggingface dataset:
Experience of using a supraclavicular flap in reconstruction of oral cavity defects
Authors: Berdigylyjov M. T. , Zaderenko I. A. , Kropotov M. A. , Aliyeva S. B. , Stelmakh D. K. , Dobrokhotova V. Z. , Berdigylyjova G. Sh. 
Published: March 2023

Introduction. In case of cancer of the oral mucosa at the first stage, the standard treatment approach is radical surgical intervention, with the formation of extensive defects leading to aesthetic and functional disorders. Taking into account the characteristics of defects, choosing a flap is a difficult task. Currently, there is a wide selection of regional and microvascular free flaps. However, not all flaps meet the requirements. The supraclavicular fasciocutaneous flap, being a regional flap, has a number of advantages: easy to harvest, reliable due to the constancy of the vascular pedicle, primary closure of the donor site, scarcity of hair, the possibility of closing various defects of the oral cavity. Aim. To evaluate the possibility of using a supraclavicular flap in patients with oral cancer to restore the defects after surgical treatment.Materials and methods. The study included 10 patients with malignant tumors of the oral cavity who underwent surgical intervention with defect replacement using supraclavicular flap at the N. N. Blokhin National Medical Research Center of Oncology between February of 2015 and May of 2021. In 4 cases, buccal mucosa was affected; in 3 cases, the retromolar area; in 1 case, oral floor mucosa; in 1 case, mandibular alveolar ridge; in 1 case, mobile tongue. Flap sizes were 5–10 × 5–8 cm. Three (3) patients had history of radiotherapy, and 1 of them had a radical dose.Results. In 4 patients without previous radiotherapy, partial flap necrosis was observed. In 1 patient, sutural diastasis in the oral cavity after partial flap necrosis was diagnosed. There were no cases of total flap necrosis and fistula formation. Suture dehiscence in the donor bed was observed in 1 patient only.Conclusion. Use of supraclavicular flap is an option for oral cavity defect replacement after surgical intervention in patients with malignant tumors of the oral cavity producing satisfactory esthetic and functional results. The advantages of this flap are simple flap dissection, reliability of vascular pedicle, flexibility, possibility of replacing large defects, scant hair coverage.
Central airway stenting in oncology
Authors: Krylovetskaya M. A. , Makarova M. V. , Komarov I. G. , Malikhova O. A. , Cherkes L. V. 
Published: March 2023

Introduction. Malignant central airway obstruction and malignant tracheoesophageal fistula in the context of tumor development are potentially life-threatening conditions which usually require immediate intervention. Airway stenting is one of the safest and most effective methods of airway patency restoration in patients with malignant obstruction of the central airways and restoration of continuity in patients with malignant tracheoesophageal fistula.Aim. To evaluate the significance of self-expandable metal stents in palliative treatment of patients with malignant central airway obstruction and malignant tracheoesophageal fistula.Materials and methods. Between 2017 and 2021 at the N. N. Blokhin National Medical Research Center of Oncology, 55 patients were observed and treated and underwent trachea stenting per the results of bronchoscopy in combination with esophagogastroduodenoscopy. The 1st group included 25 patients with malignant tracheoesophageal fistulas, the 2nd group included 30 patients with malignant central airway obstruction.Results. In the 1st group, stenting was successful in 25 (100 %) cases which allowed to adequately seal the fistula. Stent migration was observed in 1 (4 %) patient with tracheoesophageal fistula in the context of stenosing cancer of the thoracic esophagus. In the 2nd group, stenting was successful in 30 (100 %) cases. Stent migration was not observed in this patient group. In both groups, there were no complications after stent implantation. Installation of tracheal stent allowed to improve patients’ quality of life and provide a possibility for successful special treatment through low-trauma manipulation.Conclusion. According to the obtained data, endoscopic trachea stenting is the most important method of palliative treatment of tumor-related trachea lesions with development of tracheoesophageal fistulas, malignant central airway obstructions and associated sub- and decompensated pulmonary insufficiency.
Methylation of the tumor associated genes in head and neck squamous cell carcinoma
Authors: Kurevlev S. V. , Tskhovrebova L. V. , Aghajanyan A. V. , Fatkhudinov T. Kh. , Gordon K. B. , Azova M. M. 
Published: March 2023

Introduction. Head and neck cancer is a heterogenous group of malignant tumors of different etiologies, molecular mechanisms of which are still insufficiently studied.Aim. Investigation of DNA methylation status of some tumor associated genes (RASSF1A, RASSF2, RASSF5, CDO1, MEST and WIF1) in patients with head and neck squamous cell carcinoma.Materials and methods. The DNA methylation level of normal and tumor tissues was analyzed using bisulfite conversion and methylation-sensitive high-resolution melting in 25 patients (21 men and 4 women) diagnosed with neck squamous cell carcinoma.Results. There were significant differences in levels of DNA methylation between tumor and normal tissues in the CDO1 and WIF1 genes in all groups and subgroups of patients (larynx and other cancers, squamous cell carcinoma keratinizing and non-keratinizing, primary and recurrent tumor, smokers and non-smokers). The methylation level in the CDO1 gene in tumor tissue was significantly increased in the T4 and T3 stage subgroups compared to T2.Conclusion. The increased level of methylation of the CDO1 and WIF1 genes, as well as changes in their expression are among the molecular mechanisms involved in the neck squamous cell carcinoma development. They can be considered as prognostic and diagnostic markers for this pathology.
Retrospective comparison of individual risk factors hemithyroidectomy and thyroidectomy in patients with papillary carcinoma of the thyroid gland in combination with autoimmune thyroiditis
Authors: Ryabchenko E. V. 
Published: March 2023

Introduction. Papillary thyroid carcinoma is the most common subtype of thyroid cancer as it comprises 95 % of cases. Frequently, this pathology develops in the presence of autoimmune thyroiditis (Hashimoto’s thyroiditis) which is the main cause of hypothyroidism in various rich in iodine regions. Papillary thyroid carcinoma is characterized by good prognosis, however some patients experience recurrence which depends on the volume of surgical intervention.Aim. To compare clinical outcomes and complications after hemithyroidectomy (HE) and thyroidectomy (TE) in patients with papillary thyroid carcinoma secondary to autoimmune thyroiditis.Materials and methods. The retrospective study included 2031 patients with papillary thyroid carcinoma. Considering individual risk factors, 67 patients were excluded from the HE group, and 588 patients were excluded from the TE group. Each group included 688 patients for whom data were matched. Such individual factors as age, sex, primary tumor size, extrathyroidal invasion, multifocal tumor and cervical lymph node metastasis were taken into account.Results. During 10‑year follow-up, recurrence was diagnosed in 26 (3.8 %) patients of the HE group and 11 (1.6 %) patients of the TE group. Relative risk of recurrence was significantly lower after TE than after HE (risk ratio (RR) 0.41; 95 % confidence interval (CI) 0.21–0.81; р = 0.01). In the HE group, for the majority of patients recurrence was observed in the contralateral lobe of the thyroid (84.6 %). In the TE group, there were no recurrences in all patients. There were no significant differences between the groups after exclusion of recurrence in the contralateral thyroid lobe (RR 2.75; 95 % CI 0.08–8.79; р = 0.08). In the TE group, the number of patients with transient and permanent hypothyroidism in the TE group was significantly higher than in the HE group (р <0.001).Conclusion. Hemithyroidectomy is appropriate for the majority of patients with papillary thyroid carcinoma in the absence of extrathyroidal invasion in the neighboring tissues per preoperative examination. For patients after HE, preoperative and postoperative diagnostic examinations are important as most recurrences develop in the contralateral thyroid lobe.
Distant metastasis of alveolar rhabdomyosarcoma with pancreatic parameningeal localization in children: clinical case series
Authors: Rodina A. D. , Polyakov V.  G. , Gorbunova T.  V. , Merkulov O.  A. , Kashanina A.  L. , Odzharova A. A. , Stroganova A.  M. 
Published: March 2023

Rhabdomyosarcoma is a malignant neoplasm that develops from embryonic mesenchymal cells, with an annual incidence of 4.3 cases per 1,000,000 children. The prevalence of the tumor process is estimated on the basis of data from a comprehensive examination, including magnetic resonance imaging with intravenous contrast, ultrasound examination of the primary focus of regional and distant metastasis zones, computed tomography and radioisotope studies. The overall 5-year survival rate for localized rhabdomyosarcoma reaches 70 %. During the initial diagnosis, distant metastasis to the lungs, bones, and bone marrow is detected, which significantly worsens the prognosis in 20–25 % of patients. The factors of an extremely unfavorable prognosis for the course of alveolar rhabdomyosarcoma are the occurrence of regional and distant metastases before the start of specific treatment, dissemination of the tumor lesion during treatment, and the presence of translocation of the 13q14 sector. Publications contain data on a high (11.2 %) prevalence of metastases of alveolar rhabdomyosarcoma in the pancreas. In the presence of metastatic lesions of the pancreas, surgical treatment is effective only in combination with chemoradiotherapy. Long-term results of treatment of this cohort of children are unsatisfactory due to the high risk of recurrence and dissemination of the tumor.Aim. To study risk factors, evaluate methods and prospects for the treatment of children with metastatic pancreatic lesions in parameningeal alveolar rhabdomyosarcoma. The article considers three clinical cases of such a lesion. We would like to draw the attention of pediatric oncologists and radiologists to the possible association of metastases in the pancreas in children with localization of rhabdomyosarcoma in the head and neck region, which requires improvement of examination protocols in this group of patients.
Comparative evaluation of open reduction and internal fixation using delta plate versus conservative treatment in management of mandibular subcondylar fractures in adults
Authors: Bhavsar Bijal Chetas , Patel Hiren Dharmendra , Pandya Haren Bharat , Dewan Hitesh Sudarshan , Shah Urvi Hiren , Patel Hirak Biraj , Dave Harsh Manoj , Raval Chirag Prahlad 
Published: March 2023

The aim of the evaluative study was to compare the efficacy of standard conservative treatment and the open reduction internal fixation (ORIF) using the delta titanium plates in the mandibular subcondylar fractures in adults. Patients who diagnosed with mandibular subcondylar fracture in the department from January 2018 up to September 2019 were recruited into the study. The patients satisfying the inclusion criteria were randomly assigned to two groups in a 1:1 ratio (10 in each group). Group A comprised patients treated using delta titanium plates through open reduction and internal fixation and Group B comprised patients treated with closed reduction. Informed consent was taken for all the patients. All the patients of Group A underwent ORIF under GA via retromandibular approach. Pain was significantly higher in 1 and 3 month follow up in group B compared to group A. Comparison of mouth opening in both the groups show statistically significant difference at 3 and 6 month compared to baseline mouth opening. Deviation was more prevalent at 1 and 3 month follow up in group B compared to group A. Presence of mandibular deviation at 1, 3 and 6 month was statistically insignificant for both the groups.Our experience with 3D stable delta plate provides better treatment outcomes in terms of easy adaptation to the anatomy of the fracture site, better 3D stability and functional osteosynthesis.
Surgical treatment of complex odontoma in anterior maxilla – A rare case report
Authors: Kabilan Sindhuja , Shah Kanchan , Landge Jayant , Badhan Tejal , Goyal Parul , Choudhary Yashpal 
Published: March 2023

Odontomas are the odontogenic tumour which are benign whose origin is from epithelial and mesenchymal cells. These have a high incidence rate and are widely acknowledged as hamartomas. Odontomas are mainly made up of enamel and dentin, with differing amounts of cementum and pulp. The aetiology is not known yet, the hypothesized causes are: local trauma, infection, inheritance and genetic mutation. Most of these lesions are not symptomatic and are frequently diagnosed on routine radiographs. They are divided histologically into complex and compound odontomas.These are generally diagnosed in the posterior region of the mandible and resemble haphazardly arranged tooth‑like structure. Here, we report the case of a patient who is 21 years of age with a complex odontoma-related impaction of permanent maxillary right central incisor which was managed by surgical excision through palatal approach.
Relationship between the Castelli risk indeces and the presence and severity of ischemia in non-geriatric patients with suspected coronary artery disease
Authors: DOĞANAY Birsen 
Published: March 2023

Aims: This study aimed to investigate the relationship between ischemia severity and Castelli risk indices (CRI) levels in non-geriatric patients with suspected coronary artery disease (CAD) referred to myocardial perfusion scintigraphy (MPS) with gated single photon emission computed tomography (SPECT).
Material and Methods: This retrospective study included 417 non-geriatric patients referred to SPECT MPS for suspected CAD at the Cardiology Clinic between January 2019 and January 2021. Patients were divided into normal, mild, moderate, and severe ischemia groups according to MPS. CRIs were calculated as follows: CRI-I = total cholesterol / HDL ratio; CRI-II = LDL / HDL ratio.
Results: The CRIs levels were higher in ischemia group than non-ischemia group. Increase in CRI-II level was associated with increased ischemia severity. Increased CRI-II level was found to be an independent predictor of mild, moderate and severe ischemia group, but CRI-I was similar in moderate and severe ischemia groups. The threshold value of CRI-II for predicting the presence of ischemia was >2.1 (AUC ± SE = 0.787 ± 0.02, sensitivity = 79.5%, specificity = 71.4%). The threshold values of CRI-II showed a gradual increase in predicting the severity of ischemia.
Conclusion: CRI-II offers offers gradually increasing threshold values in distinguishing patients with suspected CAD but without perfusion defects or determining its severity in the case of ischemia. CRI-II can be a potential screening tool for patients with suspected CAD and it can be used for risk stratification.
THE EFFECTIVENESS OF HEALTH EDUCATION IN IMPROVING HIV/AIDS KNOWLEDGE AMONG LOW INCOME PEOPLE IN PONDONG BARU VILLAGE
Authors: Dewi Annita Viesta Nirmala , Wahidah Nurul Jannatul , Muzayyaroh Muzayyaroh 
Published: March 2023

<p><strong>Background</strong>: The number of new HIV/AIDs infection has been increasing around the world. A way to decrease this problem is by increasing people awareness through giving health education. Based on some preliminary research, communities in Pondong Baru Village have not enough knowledge about HIV/AIDS.</p><p><strong>Objective:</strong> This study aims to know the effectiveness of health education improving HIV/AIDS knowledge among low income people in Pondong Baru Village.</p><p><strong>Methods:</strong> This research was quasy experimental with pre post-test one group only, conducted in Pondong Baru Village, Paser, East Kalimantan, on 13<sup>th</sup> December 2021. The population of this research were people in Pondong Baru Village with low income. The sample were as many as 31 peoples selected by purposive sampling. Data collect using questionnaires and the analysis used Wilcoxon signed rank test with SPSS IBM 25 version.</p><p><strong>Result:</strong> Respondents’ classified based on age groups is undefined (9,7 %), 20-40 years old (35,5 %), and &gt;40 years old (54,8 %). Then, respondents’ education levels is no education (16,1 %), primary school (74,2 %), and junior high school (9,7%). Lastly, respondents’ parity is primipara (4,85 %), multipara (90,3 %), nullipara (4,85%). Before intervention, respondents had under average knowledge (93,5) and upper average knowledge (6,5%). After intervention, all respondents’ had upper average knowledge. Knowledge level after intervention (Mean:12.32; SD: 1.05) was higher than before intervention (Mean: 0.32; SD: 1.27) and it was statistically significant (P &lt; 0.001).</p><p><strong>Conclusion:</strong> It can be concluded that health education is effective in improving HIV/AIDS knowledge among low income people in Pondong Baru Village.</p>
ORGANIZATION OF LOGISTICS SERVICE AT MACHINE-BUILDING ENTERPRISES
Authors: Maslak Olga , Trunina Iryna , Gryshko Natalia , Maslak Mariya , Yakovenko Yaroslava 
Published: March 2023

The modern approaches to the interpretation of "logistics service", which is considered a set of functions and types of activities; a set of services; labor products; components of customer service; the process of creating goods are analyzed in the article.
The various services to consumers, which are provided in the process of selling finished products of the machine-building enterprise are described in the work.
This study is devoted to the problems of logistics service, considering the peculiarities of the machine-building industry. The types of logistics service for consumers (logistics service for the movement of material flows; information logistics service; financial logistics service; personnel logistics service) related to the technology and organizational structure of service, quality indicators, determination of the optimal level of service are distinguished by authors.
Eight stages of the logistics service system of a machine-building enterprise (from market segmentation, analysis of logistics services of competitors, ranking of services, their structure and priorities to the assessment of the level of logistics service and constant control over the quality of the provided logistics services) are focused at the article and indicators of assessment of the level of logistics service (availability, functionality, reliability) are outlined.
FEATURES OF THE COLLECTIVE METHOD OF MANAGEMENT DECISION MAKING IN RISK CONDITIONS
Authors: Shmatko Nataliia , Karminska-Bielobrova Maryna , Pantelieiev Mykhailo 
Published: March 2023

At the stage of economic development, significant changes took place in the field of managerial decision-making. Private business presupposes freedom of action for the owners of organizations to solve their economic problems; therefore, managers at all levels of management are faced with a number of methodological problems. Attention should be paid to the emergence of not only complexity in management, but also requirements for the quality and efficiency of decisions. In the management process, managers strive to find a solution that is objectively beneficial not only to the internal environment, but also to the contact audience of the organization. The relevance of the study is due to the fact that the modern external environment contributes to the emergence of complex problems, the effective solution of which is possible only with the help of methods of collective decision-making.
The adopted management decisions are always projected into the future, therefore, at the time of making a decision, a manager cannot know with absolute certainty how the situation will change. In other words, at the moment of making management decisions, there is a significant element of uncertainty and risk. Uncertainty conditions exist when the leader does not know exactly the outcome that each choice will have. Under risk conditions, the probability of the outcome of each decision can be determined with a known probability. When making management decisions in conditions of uncertainty and risk, it is necessary to carry out a risk analysis. After conducting a risk analysis, in the process of developing management decisions, special risk management techniques are used. This article examines the use of a collective method of making managerial decisions for the optimal achievement of goals and increasing the efficiency of work in an enterprise under conditions of risk.
Employee Performance: QWL, Communication, and Work Discipline at Detention Center
Authors: Sofa Dina Maria , Astuti Mudji 
Published: March 2023

This research aimed to determine the influence of quality of work life (QWL), communication, and work discipline on performance at the Surabaya immigration detention center, Ministry of Law and Human Rights, East Java Regional Office. This was a quantitative research with hypothesis testing, using multiple linear regression analysis with SPSS version 18 for Windows. The sample consisted of 52 staff members at the immigration detention center in Surabaya. Primary data was collected through a questionnaire using a Likert scale that was tested for validity and reliability. The results of this research showed that QWL, communication, and work discipline have a significant influence on employee performance. Additionally, QWL, communication, and work discipline have a simultaneous effect on employee performance.
Highlights :

QWL, communication, and work discipline have a significant influence on employee performance at the Surabaya immigration detention center.
The study used a quantitative research design with hypothesis testing and multiple linear regression analysis to examine the relationship between QWL, communication, work discipline, and employee performance.
The results highlight the importance of addressing QWL, communication, and work discipline in promoting employee performance in detention center settings.

Keywords: Quality of Work Life (QWL), Communication, Work Discipline, Employee Performance, Immigration Detention Center.
Case Study: Frac-Hit Occurrence Prediction in Shale Wells Using Artificial Intelligence
Authors: Mohaghegh Shahab D. , Zamirian Mehrdad 
Published: March 2023

AbstractA Frac-Hit is defined as the communication between an existing horizontal parent well and hydraulic fracturing treatment of the new well called child well. When a parent well is "hit", it can be very problematic both operationally and economically depending on the severity of the "hit". In industry, a Frac-Hit is considered dominantly a function of well spacing and subsequently the number of wells in a given shale asset that increases, the probability of interference between parent and child wells increases significantly. However, by increasing the distance between the wells, the recovery of hydrocarbon from the shale asset reduces. Commonly used techniques such as Rate Transient Analysis (RTA) and Numerical Reservoir Simulation, inherited techniques from conventional reservoirs, have proven to be unrealistic due to their degree of assumptions and simplifications during modeling and evaluation of unconventional resources (Mohaghegh, 2017, Raterman et. al, 2017, Quintero, 2022). In this case-study, AI/ML techniques, which is a pure data-driven, fact-based method without any assumptions, simplifications, and interpretations, is used to predict and mitigate the Frac-Hit occurrence more accurate than common practices in industry.