bluuebunny/crossref_metadata_2025_split huggingface dataset:
Difference of fatigue in patients on peritoneal dialysis versus hemodialysis and the association with nutrition and inflammation: a cross-sectional study
Authors: Peng Xinyue , Yang Fengjie , Wu Hong , Ouyang Qin , Li Yuxin , Wang Jianwen 
Published: December 2022

AbstractBackground Fatigue not only has a high incidence in dialysis patients, but also has a serious adverse impact on the quality of life of dialysis patients. To compare the difference of fatigue in patients on peritoneal dialysis (PD) versus hemodialysis (HD), and explore the association of fatigue with nutrition and inflammation of patients on PD or HD. Our study will provide a basis for the prevention and intervention of fatigue in dialysis patients. Methods A cross-sectional study was used. Questionnaire survey and clinical data collection were performed for patients received regular PD or HD in our hospital between June 2019 and January 2020. The difference of fatigue was compared between patients on different dialysis. Pearson correlation analysis was performed to explore the association of fatigue with nutrition and inflammation, and multivariate stepwise regression was performed to explore the influencing factors of fatigue in patients on PD and HD. Results The prevalence of fatigue in patients on PD and HD was 97.5% and 98.9% respectively, and the percentage of patients with moderate fatigue was the highest. Fatigue in patients on PD was positively correlated with white blood cells(WBC), and negatively correlated with hemoglobin(Hb), albumin(ALB), prealbumin(PALB), and serum iron(SI). Fatigue in patients on HD was positively correlated with WBC and platelet(PLT), and negatively correlated with Hb and ALB. Multivariate stepwise regression showed that serum ALB, WBC, Hb, and SI were major influencing factors for fatigue in patients on PD, and serum ALB was the major influencing factor for fatigue in patients on HD. Conclusions The prevalence of fatigue is relatively high in patients on dialysis. The general fatigue and physical fatigue in patients on PD are both lower than patients on HD. Inflammation and nutrition are major influencing factors for fatigue in patients on dialysis.
Dyshomeostasis of iron and its transporter proteins in cypermethrin-inducedParkinson’s disease
Authors: Sachan Nidhi , Tiwari Neha , Patel Devendra Kumar , Katiyar Diksha , Saripella Srikrishna , Singh Mahendra Pratap 
Published: December 2022

Abstract
The aetiology of Parkinson’s disease (PD) is highly complex and is still indefinable. However, a number of studies have indicated the involvement of pesticides and transition metals. Copper, magnesium, iron and zinc haveemerged asimportantmetal contributors. Exposure to pesticides cause an accumulation of transition metals in the substantia nigra (SN) region of brain. Cypermethrin model of PD is characterized with mitochondrial dysfunction, autophagy impairment, oxidative stress, etc. However, the effect of cypermethrin on metal homeostasis is not yet explored. The study was designed to delineate the role of metals and their transporter proteins in cypermethrin-induced animal and cellular models of PD. Level of copper, magnesium, iron and zinc waschecked in the nigrostriatal tissue and serum by atomic absorption spectroscopy. Since cypermethrin consistently increased iron content in the nigrostriatal tissue and serum after 12 weeks of exposure, level of iron transporter proteins, such asdivalent metal transporter-1 (DMT-1), ceruloplasmin, transferrin, ferroportin and hepcidin and their in silico interaction with cypermethrin were checked. 3,3′-Diaminobenzidine-enhanced Perl’s staining showed anelevated number of iron positive cells in the SN of cypermethrin-treated rats. Molecular docking studies revealed a strong binding affinity between cypermethrin and iron transporter protein receptors of human andrat. Furthermore, cypermethrin increased the expression of DMT-1 and hepcidin while reduced the expression of transferrin, ceruloplasmin and ferroportin in the nigrostriatal tissue and human neuroblastoma cells. These observations suggest that cypermethrin alters the expression of iron transporter proteins leading to iron dyshomeostasis, which could contribute to dopaminergic neurotoxicity.
Checking the rationality of a kind of Theta Functions by starting with a formula of Poisson
Authors: Louiz Akram 
Published: December 2022

Abstract
This is a mathematical example and a logical opportunity for those who doubt the summation of Poisson orthe related definitionsof Riemann. By using a formula of Poisson, this article makes a mathematical proof byconsidering that a limit of a sum is rational. Finally, you will find a logical explanation based on mathematicalprinciples that may be helpful for all students of Analysis who will find a new opportunity to demonstrate.
Sluggish dislocation mobility and high propensity for cross-slip at elevated temperatures in the MoNbTi Refractory Multi-Principal Element Alloy
Authors: Jones Morgan , Fey Lauren , Beyerlein Irene 
Published: December 2022

Abstract
Numerous body-centered cubic (bcc) refractory multi-principal element alloys (RMPEAs) exhibit high-temperature strength that surpass the performance of Ni-based superalloys. The superior properties of RMPEAs have been shown to stem in part from the unique dislocation glide mechanisms in a compositionally disordered system. Here, we assess the temperature-dependent mobility of edge and screw dislocations in MoNbTi with a bcc, random solid solution microstructure. When both dislocation types are subjected to a Schmid stress state, we find that mobility is low compared to glide in pure Nb. Interestingly, the edge/screw mobility ratio is found to increase with temperature in MoNbTi due to sustained sluggish screw mobility. Under a non-Schmid stress state, it is revealed that cross-slip occurs more easily in MoNbTi than in Nb and at elevated temperatures.These findings support the notion that sluggish glide in RMPEAs contributes to high-temperature strength, while easy cross-slip contributes to high strain hardening.
Mesoporous FeCo2O4 nanosheet-supported Pt for oxygen reduction and oxygen evolution reaction bi-functional catalytic performance
Authors: Li Sirong , Zhao Mengyao , Wang Zhenlong , Zhang Zhanyu , Yan Zhiyong , Xiao Xuechun 
Published: December 2022

Abstract
The development of new energy storage and conversion pathways has gradually freed people from dependence on oil, and improving conversion efficiency and safety is still the mainstream trend in the development of new energy sources, and electrode catalysts have become crucial in solving these problems. At present, precious metal catalysts have good performance, but the scarcity of resources and the high price limit commercialization. Therefore, it is very important to develop a catalyst for commercialization. In this paper, the Pt nanoparticles were successfully loaded on the mesoporous FeCo2O4 nanosheet catalyst by the sodium borohydride (NaBH4) reduction method. The formation of the Pt-O bond results in covalent coupling between Pt and FeCo2O4. The increase in defect sites also facilitates improved catalytic activity. According to the test results, the ORR process is mainly carried out through the "4-electron reaction" pathway, and the main product is water, and the Tafel slope of Pt-FeCo2O4 (-73 mV dec-1) is smaller than that of Pt/C (-84 mV dec-1) and FeCo2O4 (-76 mV dec-1). The stability of Pt-FeCo2O4 to ORR (After 12 h, only 15.5 % current density loss) is significantly higher than that of commercial Pt/C. Meanwhile, in the OER process, Pt-FeCo2O4 (28.1 mA cm-2) has a higher current density than RuO2 (24.4 mA cm-2) and FeCo2O4 (15.1 mA cm-2). Therefore, Pt-FeCo2O4 can be used as a bifunctional catalyst to accelerate the ORR and OER processes, which has important theoretical research significance and commercial value.
Graph-Based Feature Extraction on Object-Centric Event Logs
Authors: Berti Alessandro , Herforth Johannes , Qafari Mahnaz , Aalst Wil M.P. van der 
Published: December 2022

Abstract
Process mining techniques are widely used to uncover performance and compliance problems. However, the traditional focus on a single object type (i.e., case) is a limiting factor
when considering real-life information systems.
Therefore, there is an increased interest in object-centric process mining.
This paper proposes a graph-based approach for feature extraction on object-centric event logs. The conversion of the event log
to a set of numeric vectors is the starting point for the application of any machine learning technique (classification, prediction, clustering, anomaly detection)
on top of the event data. However, while feature extraction on traditional event logs is established, object-centric event logs are more difficult to encode in numeric
features because the events are related to several interconnected objects. Here, we try to close this gap and propose techniques and tools implementing feature extraction on object-centric event logs. The usefulness of the proposed features
is discussed on top of four problems in a Procure-to-Pay process.
The role of FGF3 in the guidance of prethalamic GABAergic axons
Authors: Huang Hong , Chen Qingyi , Zhang Weiyun , Yu Shuyang , Zhang Chunping , Xu Zhengang , Xiao Li , Liu Fang 
Published: December 2022

AbstractThe thalamus plays a crucial role in ensuring faithful transfer of sensory information, except olfactory signals, to corresponding cortical areas. However, thalamic function is not simply restricted to relaying information to and from the cerebral cortex. The ability to modulate the flow of sensory information is supported by a second abundant neuronal type in the prethalamus, the inhibitory GABAergic neurons, which project inhibitory GABAergic axons to dorsal thalamic glutamatergic neurons. Here, expression analyses reveal that morphogen fibroblast growth factor (FGF)-3 is expressed in the chick hypothalamus during the trajectory of pioneer prethalamic axons. Then, usingin vitroanalyses in chick explants, we identify a chemorepellent effect of FGF3 on nearby prethalamic axons. Moreover, inhibition of FGF3 guidance functions indicates that FGF3 signaling is necessary for the correct navigation of prethalamic axons. To test which downstream pathway is involved in the navigation of prethalamic axons, we used expression analyses and loss of function studies. We find that FGF3 mediates prethalamic axonal guidance through the FGFR1 downstream pathway. Together, these results suggest that FGF3 expressed in the hypothalamus functions as a chemorepellent molecule to direct the pathway selection of neighbouring GABAergic axons.
Establishment and validation a prognostic nomogram for early-onset colon cancer patients in stage I-II
Authors: Li Dongdong 
Published: December 2022

Abstract
Purpose
The study aims to establish and validate a nomogram model to predict the survival of early-onset colon cancer patients in stage I-II.
Methods
The eligible patients were extracted from the Surveillance, Epidemiology, and End Results (SEER) database between 2012 to 2015.Patients were be divided into training group and validation group in a 7:3 ratio randomly. The significant prognostic factors were identified through univariate and multivariate analysis and they were be constructed nomogram model. The predictive performance of the nomogram was evaluated by the concordance index (C-index), calibration plots, decision curve analysis (DCA).
Results
Our study totally enrolled 3528 early-onset CC patients in stage I-II, of 2469 patients in the training cohort and 1059 in the validation cohort. Race, Marital status, and T stage were be confirmed the independent prognostic factors after univariate and multivariate analysis. The C-index of nomogram were 0.724 and 0.692 in the training and validation cohorts, respectively. Likewise, the calibration plots showed the good consistency in the probability of 3-, 5-years OS between the actual observation and the nomogram prediction in the training. The DCA showed the good clinical practical efficacy of the nomogram model. Moreover, the patients be divided into two different risk score groups in two cohorts based the nomogram. The low-risk group had a better survival than the high-risk group.
Conclusion
We developed and validated a meaningful prognostic nomogram model for stage I-II colon cancer patients of early-onset, which clinicians could apply it to make better decisions for individual patient.
A prospective, double-blinded cohort study using Quantitative fetal fibronectin testing in symptomatic women for the prediction of spontaneous preterm delivery
Authors: Ng Vivian Wai Yan , Seto Mimi Tin Yan , Lewis Holly , Cheung Ka Wang 
Published: December 2022

Abstract
Background
Quantitative fetal fibronectin (fFN) is under-utilised in Hong Kong. Our objective was to evaluate the effectiveness of quantitative fetal fibronectin (fFN) to predict spontaneous preterm birth in women with symptoms or signs of threatened preterm labour.
Methods
A prospective, double-blinded cohort study of women with a singleton gestation and with preterm labour symptoms presenting to a tertiary hospital in Hong Kong between 24 + 0 to 33 + 6 weeks was performed from 1st October 2020 and 31st October 2021. Women with vaginal bleeding, ruptured membranes, and cervical dilation > 3 cm were excluded. The primary outcome was spontaneous preterm birth < 37 weeks. Test characteristics of quantitative fFN at different thresholds were evaluated.
Results
48 women were recruited. 10 mothers had preterm delivery (< 37 weeks' gestation) and 9 delivered within 48 hours. The NPV to predicting delivery within 14 days is 97.3% using a cut-off of < 50ng/ml and it is 100% when using 10ng/ml as cut-off. On the other hand, using 200 ng/ml as cut-off can also reliably predict women who delivered within 48 hrs– 7 days with PPV of 100%; as well as PTB before gestation 34 weeks and before 37 weeks.
Conclusions
Quantitative fFN provides different thresholds in addition to the qualitative method (50 ng/mL) to discriminate the risk of preterm delivery in symptomatic women. The high negative predictive value could help clinicians ruling out preterm labour and reducing unnecessary interventions.
Hydraulic analogy: some of practical application and limits of applicability
Authors: Yakubov Joseph , Musabekov Bakhram 
Published: December 2022

Abstract
In the first part of the article, an essential aspect of the limits of applicability of the hydraulic analogy is shown. The assumption is that there is no acceleration along the vertical axis when the fluid flows in an open channel. The effect of vertical acceleration is estimated. The authors suggest that when using the method of towing models in a fixed layer of "shallow water" in experiments in a hydraulic channel, new unique possibilities arise for modelling aerodynamic processes, including those that are difficult or even unreproducible by known means of physical modelling. Analog technical devices are described and examples of visualized pictures of complex shock wave structures are shown.
Dysregulation of a lncRNA within the TNFRSF10A locus activates cell death pathways
Authors: Farkas Michael , Kaczynski Tadeusz , Husami Nadine , Au Elizabeth 
Published: December 2022

AbstractTNFRSF10A (tumor necrosis factor receptor superfamily member 10A)encodes a cell surface receptor protein involved in apoptotic, necroptotic, and inflammatory pathways. Dysregulation ofTNFRSF10Ahas been implicated in sensitization to apoptosis and to the development of multiple diseases, yet little is known of theAC100861.1long noncoding RNA (lncRNA) that lies head-to-head withTNFRSF10A. Given its genomic positioning, we sought to investigate the function ofAC100861.1, focusing on its potential relationship withTNFRSF10Aand the role it may play in death receptor signaling. Using knockdown and overexpression strategies, we probed cell viability and examined transcript and protein level changes in key genes involved in apoptosis, necroptosis, and inflammation. Decreased cell viability was observed uponTNFRSF10Aoverexpression, regardless of whether the cells were subjected to the chemical stressor tunicamycin. Similarly, overexpression ofAC100861.1led to increased cell death, with a further increase observed under conditions of cellular stress. Knockdown ofTNFRSF10Aincreased cell death only when the cells were stressed, andAC100861.1knockdown exhibited no effect on cell death. Neither knockdown nor overexpression of either of these genes greatly affected expression of the other. ManipulatingAC100861.1, however, led to marked changes in the expression of genes involved in necroptosis and inflammatory cell signaling pathways. Additionally, RNA fluorescencein situhybridization (RNA-FISH) revealed that theAC100861.1transcript is localized primarily to the cytoplasm. Together, these data suggest thatAC100861.1may have a role in regulating necroptotic and inflammatory signaling pathways, and that this function is separate from changes inTNFRSF10Aexpression. Given the importance of this genomic locus for cell survival, these data provide insight into the function of a poorly understood lncRNA with potential implications regarding disease pathology and treatment.
Performance studies of constructed wetlands for treatment of wastewater under temperate climatic conditions
Authors: Harne Kailash , Joshi Himanshu 
Published: December 2022

Abstract
Phytoremediation also known as constructed wetlands is an effective method of treatment of municipal as well as industrial wastewater. The efficacy of this method has already been tested in European and American countries and found to be the best method of wastewater treatment. Efforts have been made in the present work to check the efficacy of phytoremediation in the form of constructed wetlands under Indian climatic conditions. A pilot plant of constructed wetlands has been constructed on the premises of the Uttaranchal Jal Nigam Sewage treatment plant and municipal wastewater has been allowed to pass through the constructed wetland. It has been observed that BOD removal at 24 0C is governed by the equation Ce/Co = e-1.0042 x t and the removal rate constant of BOD has been observed to be 0.795 d-1 at 20 0C. It has been observed that the pilot-scale constructed wetland is bringing effluent BOD and TSS up to 20 mg/l and 30 mg/l respectively consistently for the duration under study. The values of hydraulic retention time, hydraulic loading, and organic loading for achieving this performance are found to be 1.75 days,13.22 cm/d, and 142.78 kg/ha. d respectively. Performance study of constructed wetland and the existing activated sludge treatment has shown that the percent removal for the parameters TSS, BOD, COD, and Fecal Coliforms is near to the same order except for TN and TP, where the activated sludge process unit shows higher removal than the constructed wetland.
Effect of chemical clogging on the permeability of weakly consolidated sandstone due to reinjection at different temperatures
Authors: Zhong Tao , Tian Hong , Zheng Jun , Dou Bin , Wang Yachao , Yang Zhongyan , Li Peng , Xiao Peng 
Published: December 2022

AbstractWhile utilizing hydrothermal resources, it is necessary to reinject wastewater into the reservoir through reinjection wells to extract heat without mining groundwater. Chemical clogging is a serious problem in the process of reinjection. The precipitation of minerals can lead to reservoir clogging and the reduction of permeability. Therefore, to study the effect of chemical clogging on permeability, the weakly consolidated sandstone of the Neogene Guantao Formation geothermal reservoir in northern Shandong (Eastern China) was taken as the research object. A long-term thermal-hydro-mechanical-chemistry (THMC) coupling reinjection experiment was carried out. The results showed that when the temperature of wastewater was higher than 45 °C, there was a temporary phase of permeability enhancement in the first 10 min of reinjection. However, wastewater with higher temperatures would cause more chemical clogging eventually. XRD and ion analysis results showed that the precipitation of minerals was mainly potash feldspar, illite, calcite, and other carbonate minerals during reinjection. According to the characteristics of low-TDS wastewater in the Guantao Formation, it is recommended to adopt low-temperature wastewater reinjection and reduce the concentration of Ca2+ and Mg2+ in wastewater before reinjection.
Inversion-based identification of DNAPLs-contaminated groundwater based on surrogate model of deep convolutional neural network
Authors: Miao Tiansheng , Guo Jiayuan , Li Guanghua , Huang He 
Published: December 2022

Abstract
This paper combines theoretical analysis with practical examples to examine outstanding issues in research on the inversion-based identification of dense non-aqueous phase liquids (DNAPLs) in groundwater. We first generalize the relevant geological and hydrogeological conditions to establish a conceptual model of groundwater contamination. We then use it to formulate a preliminary model of the contamination of groundwater by DNAPLs based on multi-phase flow to describe the mechanism of migration of these pollutants. Following this, a surrogate model is established by training and validating the deep convolutional neural network (DCNN) based on training samples and samples for verification. Finally, the surrogate model is embedded into an optimization model as an equality constraint and the particle swarm optimization (PSO) algorithm is used to solve it.
Solid-solid Phase Transitions between Crystalline Polymorphs of Organic
Materials
Authors: Rietveld Ivo B. 
Published: December 2022

Abstract:
In this review, the analysis of solid-solid phase transitions between crystalline polymorphs of organic
molecules is discussed. Although active pharmaceutical ingredients (APIs) are the scope of the review,
whether an organic molecule has a biological activity or not does not particularly define its interactions in the
crystalline state. Therefore, other small organic molecules have been included in this analysis and in certain cases,
polymers have been discussed too. The focus of the review is on experimental analysis; however, a section
on computational and theoretical methods has been added because these methods are becoming important and
are obviously helpful in understanding for example transition mechanisms because the results can be easily visualized.
The following aspects of solid-solid phase transitions between crystalline structures are presented in this
review. The thermodynamics of phase transitions between polymorphs involving thermodynamic equilibrium
and the variables temperature and pressure closely linked to the Gibbs free energy are discussed. The two main
transition mechanisms in the organic crystalline solid, displacive and concerted, are discussed. Experimental
methods that are used to understand the mechanisms and thermodynamic equilibrium between different polymorphs
of an API are reviewed. The switching of polymorph properties is discussed, and heat storage and release
are reviewed as it is one of the main applications of solid-state phase transitions. Of interest for the control
of drug products, constraining phase transitions has been reviewed, as it may help increase the bioavailability
of an API by using metastable phases. Finally, second order phase transitions of organic materials, which appear
to be rare, are discussed. It can be concluded that although the general theory of polymorphism and phase
transitions is well understood, how it works out for a specific molecule remains difficult to predict.