bluuebunny/crossref_metadata_2025_split huggingface dataset:
Valence and sea parton correlations in double parton scattering from data
Authors: Huayra Edgar , Lovato João Vitor C. , de Oliveira Emmanuel G. 
Published: September 2023

Abstract
The effective cross section of double parton scattering in proton collisions has been measured by many experiments with rather different results. Motivated by this fact, we assumed that the parton correlations in the transverse plane are different whether we have valence or sea partons. With this simple approach, we were able to fit the available data and found that sea parton pairs are more correlated in the transverse plane than valence-sea parton pairs.
Entanglement harvesting for different gravitational wave burst profiles with and without memory
Authors: Barman Subhajit , Chakraborty Indranil , Mukherjee Sajal 
Published: September 2023

Abstract
In the present article, we study how different gravitational wave (GW) burst profiles in linearized gravity, with and without the asymptotic memory, may influence the harvesting between two static Unruh-DeWitt detectors. To this end, we investigate the following burst profiles — Gaussian, sech-squared, Heaviside step function, and tanh. Out of these, the first two bursts contain no memory, while the latter two consist of a non-vanishing memory effect. We find that in all of these cases, entanglement harvesting is possible, and it decreases with the increasing distance between detectors and the detector transition energy. We observe that the harvesting differs qualitatively based on the presence or absence of the memory, which is prominent in a low transition energy regime. With memory, the harvesting keeps increasing with decreasing transition energy, while without memory, it tends to reach finite values. Furthermore, for the two burst profiles without memory, longer bursts correspond to greater harvesting in the low detector transition energy regime, and this characteristic is reversed for larger transition energy. Meanwhile, for the tanh-type profile with memory, harvesting is always greater for shorter bursts. We discuss various implications of our findings.
Dipole superfluid hydrodynamics
Authors: Jain Akash , Jensen Kristan , Liu Ruochuan , Mefford Eric 
Published: September 2023

Abstract
We construct a theory of hydrodynamic transport for systems with conserved dipole moment, U(1) charge, energy, and momentum. These models have been considered in the context of fractons, since their elementary and isolated charges are immobile by symmetry, and have two known translation-invariant gapless phases: a “p-wave dipole superfluid” phase where the dipole symmetry is spontaneously broken and a “s-wave dipole superfluid” phase where both the U(1) and dipole symmetries are spontaneously broken. We argue on grounds of symmetry and thermodynamics that there is no transitionally-invariant gapless fluid with unbroken dipole symmetry. In this work, we primarily focus on the hydrodynamic description of p-wave dipole superfluids, including leading dissipative corrections. That theory has, in a sense, a dynamical scaling exponent z = 2, and its spectrum of fluctuations includes novel subdiffusive modes ω ∼ −ik4 in the shear sector and magnon-like sound mode ω ∼ ±k2 − ik2. By coupling the fluid to background fields, we find response functions of the various symmetry currents. We also present a preliminary generalization of our work to s-wave dipole superfluids, which resemble z = 1 fluids and feature sound waves and diffusive shear modes, as in an ordinary fluid. However, the spectrum also contains a magnon-like second-sound mode ω ∼ ±k2 ± k4 − ik4 with subdiffusive attenuation.
ε-factorized differential equations for two-loop non-planar triangle Feynman integrals with elliptic curves
Authors: Jiang Xuhang , Wang Xing , Yang Li Lin , Zhao Jingbang 
Published: September 2023

Abstract
In this paper, we investigate two-loop non-planar triangle Feynman integrals involving elliptic curves. In contrast to the Sunrise and Banana integral families, the triangle families involve non-trivial sub-sectors. We show that the methodology developed in the context of Banana integrals can also be extended to these cases and obtain ε-factorized differential equations for all sectors. The letters are combinations of modular forms on the corresponding elliptic curves and algebraic functions arising from the sub-sectors. With uniform transcendental boundary conditions, we express our results in terms of iterated integrals order-by-order in the dimensional regulator, which can be evaluated efficiently. Our method can be straightforwardly generalized to other elliptic integral families and have important applications to precision physics at current and future high-energy colliders.
Personalisierte Psychotherapie der posttraumatischen Belastungsstörung
Authors: Steuwe Carolin , Blaß Jakob , Herpertz Sabine C. , Drießen Martin 
Published: September 2023

Zusammenfassung
Hintergrund
Eine relevante Heterogenität von Behandlungseffekten bei der posttraumatischen Belastungsstörung (PTBS) wird vor dem Hintergrund der Debatte um die Notwendigkeit einer phasenbasierten Behandlung sowie in Anbetracht der neuen Diagnose der komplexen PTBS diskutiert und ist inzwischen nachgewiesen. Dennoch gibt es bisher wenig Personalisierung in der Therapie der PTBS. Ziel der vorliegenden Arbeit ist es, den aktuellen Forschungsstand zur personalisierten Auswahl bestimmter Psychotherapiemethoden zur Behandlung der PTBS anhand von Patient:innenmerkmalen durch statistische Verfahren darzustellen.

Methodik
Es wurde eine systematische Literaturrecherche in den Datenbanken PubMed (inkl. Medline), Embase, Web of Science Core Collection, Google Scholar, PsycINFO und PSYNDEX zu klinischen Studien und Übersichtsarbeiten zu personalisierter Therapie der PTBS durchgeführt.

Ergebnisse
13 relevante Publikationen wurden identifiziert, hiervon waren 5 Artikel Prädiktoranalysen in Stichproben ohne Kontrollbedingung. 7 Artikel zeigten Analysen von randomisiert-kontrollierten Studien (RCT) mit einem Post-hoc-Vergleich der Behandlungseffekte optimal und nichtoptimal zugeordneter Patient:innen. Zudem liegt ein Review-Artikel zur Behandlungsauswahl bei PTBS und komorbider BPS vor.

Diskussion
Die vorliegenden Publikationen deuten auf Bedeutung und Nutzen personalisierter Behandlung bei der PTBS hin. Die für die Personalisierung ermittelten relevanten Prädiktorvariablen sollten als Anregung genutzt werden, diese in prospektiven Studien genauer zu untersuchen.
Approximating multiobjective optimization problems: How exact can you be?
Authors: Bazgan Cristina , Herzel Arne , Ruzika Stefan , Thielen Clemens , Vanderpooten Daniel 
Published: September 2023

AbstractIt is well known that, under very weak assumptions, multiobjective optimization problems admit $$(1+\varepsilon ,\dots ,1+\varepsilon )$$

(
1
+
ε
,
⋯
,
1
+
ε
)

-approximation sets (also called $$\varepsilon $$
ε
-Pareto sets) of polynomial cardinality (in the size of the instance and in $$\frac{1}{\varepsilon }$$

1
ε

). While an approximation guarantee of $$1+\varepsilon $$

1
+
ε

for any $$\varepsilon >0$$

ε
>
0

is the best one can expect for singleobjective problems (apart from solving the problem to optimality), even better approximation guarantees than $$(1+\varepsilon ,\dots ,1+\varepsilon )$$

(
1
+
ε
,
⋯
,
1
+
ε
)

can be considered in the multiobjective case since the approximation might be exact in some of the objectives. Hence, in this paper, we consider partially exact approximation sets that require to approximate each feasible solution exactly, i.e., with an approximation guarantee of 1, in some of the objectives while still obtaining a guarantee of $$1+\varepsilon $$

1
+
ε

in all others. We characterize the types of polynomial-cardinality, partially exact approximation sets that are guaranteed to exist for general multiobjective optimization problems. Moreover, we study minimum-cardinality partially exact approximation sets concerning (weak) efficiency of the contained solutions and relate their cardinalities to the minimum cardinality of a $$(1+\varepsilon ,\dots ,1+\varepsilon )$$

(
1
+
ε
,
⋯
,
1
+
ε
)

-approximation set.
Effects of fixation and long-term preservation on finned octopods (Cephalopoda: Cirrata)
Authors: Ziegler Alexander , Sagorny Christina 
Published: September 2023

AbstractAmong mollusks, the octopods stand out due to the almost entire absence of a stabilizing shell, potentially rendering these organisms susceptible to deformation caused by fixation and preservation. Such artifacts have previously been shown to occur especially in specimens of the deep-sea taxon Cirrata, the finned octopods. As an adaptation to their extreme habitat, many cirrates are composed of (semi-)gelatinous tissues, which are particularly prone to distortion, shrinkage, and deformation following fixation and preservation. Using one or more species from each of the eight currently recognized cirrate genera, the present study provides pre- and post-fixation color imagery of entire specimens as well as measurements of taxonomically relevant characters. These novel data illustrate the sometimes drastic effects that short- and long-term chemical treatment entails for this cephalopod taxon. Both structural and color changes may occur when finned octopods are fixed and preserved using routine protocols. However, shrinkage does not occur uniformly in all taxonomically relevant structures. The consequences of such a treatment for species descriptions and identification are discussed and existing anaesthetization, fixation and preservation protocols are summarized.
Opportunities and challenges of microbial siderophores in the medical field
Authors: Passari Ajit Kumar , Ruiz-Villafán Beatriz , Cruz-Bautista Rodrigo , Díaz-Domínguez Valerie , Rodríguez-Sanoja Romina , Sanchez Sergio 
Published: September 2023

AbstractSiderophores are low-molecular-weight secondary metabolites that function as iron chelators. Under iron-deficiency conditions, they are produced by a wide variety of microbes, allowing them to increase their iron uptake. The primary function of these compounds is the environmental iron scavenging and its transport into the cytosol. Iron is then reduced to its ferrous form to operate as an enzymatic cofactor for various functions, including respiration, nitrogen fixation, photosynthesis, methanogenesis, and amino acid synthesis. Depending on their functional group, siderophores are classified into hydroxamate, catecholate, phenolate, carboxylate, and mixed types. They have achieved great importance in recent years due to their medical applications as antimicrobial, antimalarial, or anticancer drugs, vaccines, and drug-delivery agents. This review integrates current advances in specific healthcare applications of microbial siderophores, delineating new opportunities and challenges as viable therapies to fight against diseases that represent crucial public health problems in the medical field.Key points•Siderophores are low-molecular-weight secondary metabolites functioning as iron chelators.• The siderophore’s properties offer viable options to face diverse clinical problems.• Siderophores are alternatives for the enhancement of antibiotic activities.
Application of electrospun chitosan-based nanofibers as immobilization matrix for biomolecules
Authors: Christ Henrik-Alexander , Daniel Nils Peter , Solarczek Jennifer , Fresenborg Leonard Sebastian , Schallmey Anett , Menzel Henning 
Published: September 2023

Abstract
Nanofiber meshes from electrospun chitosan, highly modified with biotin and arylazides, are well-suited for application as enzyme immobilization matrices. To test this, catalytically active biomolecules were immobilized onto photocrosslinked nanofibrous nonwovens consisting mainly of biotinylated fungal chitosan and a small amount (10 w%) of poly ethylene oxide. In this study, we show that over 10 μg eugenol oxidase per milligram dry polymer matrix can be loaded on UV-crosslinked chitosan nanofibers. We further demonstrate that bound enzyme activity can be fully retained for over 7 days of storage at ambient conditions in aqueous buffer. Samples loaded at maximum enzyme carrying capacity were tested in a custom-made plug-flow reactor system with online UV-VIS spectroscopy for activity determination. High wettability and durability of the hydrophilic chitosan support matrix enabled continuous oxidation of model substrate vanillyl alcohol into vanillin with constant turnover at flow rates of up to 0.24 L/h for over 6 h. This proves the above hypothesis and enables further application of the fibers as stacked microfluidic membranes, biosensors, or structural starting points for affinity crosslinked enzyme gels.

Key points
•Biotinylated chitosan-based nanofibers retain enzymes via mild affinity interactions
•Immobilized eugenol oxidase shows high activity and resists continuous washing
•Nanofiber matrix material tolerated high flow rates in a continuous-flow setup

Graphical Abstract
Novel marine metalloprotease—new approaches for inhibition of biofilm formation of Stenotrophomonas maltophilia
Authors: Peters Marie Kristin , Astafyeva Yekaterina , Han Yuchen , Macdonald Jascha F. H. , Indenbirken Daniela , Nakel Jacqueline , Virdi Sanamjeet , Westhoff Guido , Streit Wolfgang R. , Krohn Ines 
Published: September 2023

Abstract
Many marine organisms produce bioactive molecules with unique characteristics to survive in their ecological niches. These enzymes can be applied in biotechnological processes and in the medical sector to replace aggressive chemicals that are harmful to the environment. Especially in the human health sector, there is a need for new approaches to fight against pathogens like Stenotrophomonas maltophilia which forms thick biofilms on artificial joints or catheters and causes serious diseases. Our approach was to use enrichment cultures of five marine resources that underwent sequence-based screenings in combination with deep omics analyses in order to identify enzymes with antibiofilm characteristics. Especially the supernatant of the enrichment culture of a stony coral caused a 40% reduction of S. maltophilia biofilm formation. In the presence of the supernatant, our transcriptome dataset showed a clear stress response (upregulation of transcripts for metal resistance, antitoxins, transporter, and iron acquisition) to the treatment. Further investigation of the enrichment culture metagenome and proteome indicated a series of potential antimicrobial enzymes. We found an impressive group of metalloproteases in the proteome of the supernatant that is responsible for the detected anti-biofilm effect against S. maltophilia.

Key points
• Omics-based discovery of novel marine-derived antimicrobials for human health management by inhibition of S. maltophilia
• Up to 40% reduction of S. maltophilia biofilm formation by the use of marine-derived samples
• Metalloprotease candidates prevent biofilm formation of S. maltophilia K279a by up to 20%
Update on leukodystrophies and developing trials
Authors: Ceravolo Giorgia , Zhelcheska Kristina , Squadrito Violetta , Pellerin David , Gitto Eloisa , Hartley Louise , Houlden Henry 
Published: September 2023

AbstractLeukodystrophies are a heterogeneous group of rare genetic disorders primarily affecting the white matter of the central nervous system. These conditions can present a diagnostic challenge, requiring a comprehensive approach that combines clinical evaluation, neuroimaging, metabolic testing, and genetic testing. While MRI is the main tool for diagnosis, advances in molecular diagnostics, particularly whole-exome sequencing, have significantly improved the diagnostic yield. Timely and accurate diagnosis is crucial to guide symptomatic treatment and assess eligibility to participate in clinical trials. Despite no specific cure being available for most leukodystrophies, gene therapy is emerging as a potential treatment avenue, rapidly advancing the therapeutic prospects in leukodystrophies. This review will explore diagnostic and therapeutic strategies for leukodystrophies, with particular emphasis on new trials.
The younger the better: importance of age in treatment of childhood obesity
Authors: Jørgensen Rasmus Møller , Bjørn Amanda , Bjørn Vitus , Bruun Jens Meldgaard 
Published: September 2023

AbstractChildren living with obesity are prevalent worldwide. It is an established finding that many children who start a lifestyle intervention tend to leave prematurely. The aim of this study was to identify characteristics in children with obesity who prematurely leave a lifestyle intervention. The cohort study includes children living with obesity aged 4–17, treated in a Danish family-centered lifestyle intervention between 2014 and 2017. Data were collected from patient records. BMI-SDS was calculated using an external Danish reference population and multivariable regression analysis was used to answer the research question. Of the 159 children included, 64 children who left the intervention within the first 1.5 years were older compared to those who stayed in the intervention (10.2 years ± 2.9 vs 11.5 years ± 3.1, p = 0.005). Older participants (> 66.6th percentile) had a shorter treatment duration (489 days) compared to the youngest (190 days 95% CI: 60; 320, p = 0.005) and middle third (224 days 95% CI: 89; 358, p = 0.001). Additionally, an inverse association was found between duration of treatment and age at baseline (−31 days, 95% CI (−50; −13), p = 0.001). Conclusion: The risk of leaving a lifestyle intervention prematurely was primarily dependent on the age of the participants, emphasizing the importance of including children early in lifestyle interventions.

What is Known:•Lifestyle interventions for childhood obesity that are shorter in duration often lead to short-term weight reductions only. Limited knowledge exists on why some children prematurely leave these interventions.

What is New:•This study observes a solid inverse correlation and association between age and time spent in the interventions, when treating childhood obesity. We hereby suggest age as an important determinant for the adherence to lifestyle interventions and emphasize the importance of treatment early in life.
Ratios conjecture for quadratic Hecke L-functions in the Gaussian field
Authors: Gao Peng , Zhao Liangyi 
Published: September 2023

AbstractWe develop the L-functions ratios conjecture with one shift in the numerator and denominator in certain ranges for the family of quadratic Hecke L-functions in the Gaussian field using multiple Dirichlet series under the generalized Riemann hypothesis. We also obtain an asymptotical formula for the first moment of central values of the same family of L-functions, obtaining an error term of size $$O(X^{1/2+\varepsilon })$$

O
(

X

1
/
2
+
ε

)

.
Transcriptional Knock-down of mstn Encoding Myostatin Improves Muscle Quality of Nile Tilapia (Oreochromis niloticus)
Authors: Wang Qingchun , Yan Yue , Tao Yifan , Lu Siqi , Xu Pao , Qiang Jun 
Published: September 2023

AbstractMyostatin (encoded by mstn) negatively regulates skeletal muscle mass and affects lipid metabolism. To explore the regulatory effects of mstn on muscle development and lipid metabolism in Nile tilapia (Oreochromis niloticus), we used antisense RNA to transcriptionally knock-down mstn. At 180 days, the body weight and body length were significantly higher in the mstn-knock-down group than in the control group (p < 0.05). Additionally, fish with mstn-knock-down exhibited myofiber hyperplasia but not hypertrophy. Oil red O staining revealed a remarkable increase in the area of lipid droplets in muscle in the mstn-knockdown group (p < 0.05). Nutrient composition analyses of muscle tissue showed that the crude fat content was significantly increased in the mstn-knock-down group (p < 0.05). The contents of saturated fatty acids, monounsaturated fatty acids, and polyunsaturated fatty acids were all significantly increased in the mstn-knock-down group (p < 0.05). Comparative transcriptome analyses revealed 2420 significant differentially expressed genes between the mstn-knock-down group and the control group. KEGG analysis indicates that disruptions to fatty acid degradation, glycerolipid metabolism, and the PPAR signaling pathway affect muscle development and lipid metabolism in mstn-knock-down Nile tilapia: acaa2, eci1, and lepr were remarkably up-regulated, and acadvl, lpl, foxo3, myod1, myog, and myf5 were significantly down-regulated (p < 0.05). These results show that knock-down of mstn results in abnormal lipid metabolism, acceleration of skeletal muscle development, and increased adipogenesis and weight gain in Nile tilapia.
Mining gene expression data for rational identification of novel drug targets and vaccine candidates against the cattle tick, Rhipicephalus microplus
Authors: Maritz-Olivier Christine , Ferreira Mariëtte , Olivier Nicholas A. , Crafford Jan , Stutzer Christian 
Published: September 2023

AbstractControl of complex parasites via vaccination remains challenging, with the current combination of vaccines and small drugs remaining the choice for an integrated control strategy. Studies conducted to date, are providing evidence that multicomponent vaccines will be needed for the development of protective vaccines against endo- and ectoparasites, though multicomponent vaccines require an in-depth understanding of parasite biology which remains insufficient for ticks. With the rapid development and spread of acaricide resistance in ticks, new targets for acaricide development also remains to be identified, along with novel targets that can be exploited for the design of lead compounds. In this study, we analysed the differential gene expression of Rhipicephalus microplus ticks that were fed on cattle vaccinated with a multi-component vaccine (Bm86 and 3 putative Bm86-binding proteins). The data was scrutinised for the identification of vaccine targets, small drug targets and novel pathways that can be evaluated in future studies. Limitations associated with targeting novel proteins for vaccine and/or drug design is also discussed and placed into the context of challenges arising when targeting large protein families and intracellular localised proteins. Lastly, this study provide insight into how Bm86-based vaccines may reduce successful uptake and digestion of the bloodmeal and overall tick fecundity.
Introgressive hybridization levels of Tilapiine species in Lake Victoria basin, Kenya inferred from microsatellite and mitochondrial DNA genotyping based on next-generation sequencing
Authors: Kwikiriza Gerald , Vijayan Thapasya , Tibihika Papius Dias , Curto Manuel , Winkler Gerold , Nattabi Juliet Kigongo , Kariuki John , Meimberg Harald 
Published: September 2023

AbstractDespite their high abundance and species richness, tilapiines have been compromised by various factors especially overfishing, climate change, and uncontrolled fish transfers and introductions. Fish introductions have negatively impacted native tilapiine populations through competition, predation, hybridization, and introgression compromising their genetic integrity. The hybridization levels of different tilapiines in the Lake Victoria basin remain relatively understudied. The study utilized nuclear microsatellite and mitochondrial DNA (mtDNA) genetic markers to investigate hybridization signals and compare the genetic diversity of different tilapiines in Lake Victoria, Kenya, using next-generation sequencing. Low levels of hybridization from Oreochromis niloticus into other Oreochromis species were detected by Bayesian clustering analysis and principal coordinate analysis (PCoA). The results contribute to the need for conservation measures for these fish species.