bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cross-Sectional Analysis of Periodontal Disease and Cognitive Impairment Conducted in a Memory Clinic: The Pearl Study
Authors: Saji Naoki , Ishihara Yuichi , Murotani Kenta , Uchiyama Akira , Takeda Akinori , Sakurai Takashi , Matsushita Kenji 
Published: September 2023

Background: Periodontal disease (PeD) is a risk factor of Alzheimer’s disease and is associated with cognitive decline in older adults. However, the relationships between subitems of neuropsychological tests and PeD have not been fully clarified. Objective: To evaluate associations between PeD and subitems of neuropsychological tests. Methods: We performed a cross-sectional analysis of data of 183 participants (women: 50%, mean age: 79 years) from a clinical study. We enrolled patients who visited our memory clinic and assessed demographics, dementia-related risk factors, neuropsychological tests, brain magnetic resonance images, and a dental screening check. We evaluated the relationships between cognitive function and PeD using multivariable logistic regression analyses. Results: Participants with dementia were less likely to make periodical visits to the dentist, had fewer teeth, had less frequent tooth brushing habits, and were more likely to have PeD. Impaired cognitive function was significantly associated with an increasing degree of PeD. In multivariable logistic regression analyses, impaired visuospatial function and attention were associated with twice the risk of moderate or severe PeD compared with individuals with preserved visuospatial function and attention (odds ratio: 2.11, 95% confidence interval: 1.04–4.29, p = 0.037). Impaired word recall and recognition and following commands were associated with increased risk of PeD (odds ratio: 2.80, 95% confidence interval: 1.41–5.32, p = 0.003). Conclusions: Cognitive decline, such as impaired visuospatial function, attention, word recall and recognition, and inability to follow commands were independently and strongly associated with PeD. These items can be assessed easily on a daily basis.
SANKSI PIDANA KORUPSI DALAM HUKUM POSITIF (UU NOMOR 31 TAHUN 1999 JUNCTO UU NOMOR 20 TAHUN 2001) PERSPEKTIF HUKUM PIDANA ISLAM DAN HAK ASASI MANUSIA
Authors: Sajali Munawir 
Published: September 2023

Undang-Undang tentang Pemberantasan Tindak Pidana Korupsi hanya diatur tentang korupsi material dan keuangan. Pasal 2 UU No. 31 Tahun 1999 yang disempurnakan dengan Undang-Undang No. 20 Tahun 2001 terhadap pelaku tindak pidana korupsi bagi penyelenggara negara dalam perspektif hukum Islam dilaksanakan karena sesuai dan sejalan dengan maqasid al-tasyri’ dalam artian tetap mempertimbangkan kepentingan umum yang berorientasi pada kemaslahatan dan menolak segala kemungkaran. Oleh karena itu, yang menjadi pokok masalah dalam penelitian ini adalah sanksi hukum terhadap pelaku tindak pidana korupsi menurut hukum positif di Indonesia dalam perspektif hukum pidana Islam dan HAM. Teori hukum pidana Islam yaitu mengenai pembagian dan operasionalisasi jinayah atau jarimah serta penerapan sanksi-sanksinya. Bertujuan untuk mengetahui pidana tambahan berupa pencabutan hak untuk memilih dan dipilih dalam jabatan publik jika ditinjau dari perspektif hukum pidana dan untuk mengetahui kesesuaian antara putusan hakim Mahkamah Agung Nomor 537K/Pid.Sus/2014 dengan prinsip-prinsip hak
asasi manusia.
TRENDS OF DEVELOPMENT OF PUBLIC SPACE FORMS
Authors: Ushakov Glib 
Published: September 2023

The article summarizes the main forms of public space and their types and development trends. Features of open, covered, atrium forms of public space and public space with a complex structure are described.
The conditions of the active functioning of a comfortable public space are considered. Examples of progressive projects of the organization of public space, which are implemented in world practice and which illustrate the proposed classification of public spaces by form, are given. Modern possibilities of organizing public space, which can be included inside the building and located outside relative to the buildings, are based on the main groups of forms: open public space (area with design in an open urban environment), covered public space (area with design in an open urban environment with canopy structure), atrium public space (communication and recreation atrium part of a public building) and public space of a complex structure (combination of open, covered and atrium parts: vertically at different levels or by blocking horizontally). The most complicated form of a complex with public space is a multi-level combination of a transport hub, a shopping center and a recreation area on the upper levels.
THE ROLE OF GREEN PUBLIC SPACES IN THE FORMATION OF THE URBAN ENVIRONMENT
Authors: Kyselovа Ganna , Kyselov Volodymyr 
Published: September 2023

The article analyzes the role of open green public spaces in the formation of a sustainable urban environment. In the urban planning dimension, public spaces are pedestrian streets, squares, boulevards, embankments, parks and squares, which were formed under the influence of historical, cultural, social and economic factors. In the social dimension, the listed objects are a territory publicly available for use by all residents to meet the needs of recreation, communication, sports, etc.
The article also considers the typology of open landscaped spaces. The problem of the formation of public spaces for the cities of Ukraine is particularly relevant in view of the changes of the last decades in the field of economy, sociology, urban planning concepts of sustainable development, which stimulated the transformation of cities. Consideration of public space as a structural element of the city is important in the issue of sustainable development of Ukrainian cities and requires appropriate methodological support for analysis, evaluation, modeling and management of scientific and project activities. Resolving the contradiction between the knowledge of regularities and basic theories of the interaction of sciences in the development of the city and the real state of affairs will ensure the validity of the theoretical provisions in further studies of the spatial development of the city and practical urban planning solutions.
Representation of National Identity on the Net
Authors: Snegur M. R. 
Published: September 2023

Introduction. The purpose of the article is to study and construct the typology of situations of the national identity actualization of young people in the digital space. The scientific novelty of the work lies in the study of the constructing national identity process as a result of the assimilation of institutional nation-building, passed through the filters of personal attitudes, that can be observed in the variability of representing national identity ways in various social situations. The relevance is conditioned by modern socio-political conditions and the need for in-depth study of the category of national identity.Methodology and sources. The research methodology is based on the approaches of social constructivism (the nation as an “imaginary community” by B. Anderson), symbolic interactionism (the dramatic approach of I. Goffmann), ethno-symbolism (everyday nationalism of J. Hutchinson) and memory studies (cultural memory of J. Assman). The research method is a discourse analysis of blogs in TikTok and Instagram, the unit of analysis is a blog as a case, sample size made up 127 cases. The collection of empirical data took place from 01.26.2022 to 03.10.2022.Results and discussion. The digital space provides the conditions for the maximum degree of intensity of the national identity representation, which can be represented in social networks by a wide variety of forms (costume, text, music, image, scenery, etc.). The following types of representation of national identity in the network have been identified: national identity as a “profession”, as “fandom”, national identity in the context of constant updating (migrants, intercultural marriage), in the context of everyday life, situational national identity, lack of a specific national identity.Conclusion. The conducted empirical research allows to construct the typology of situations of national identity of young people representations in the network. The typology is based on the degree of intensity of national identity representation. The typology can be represented as a continuum, on one pole of which there is a vivid representation of national identity, on the other - an active blurring and confusion of national markers.
Empowering the Association of Indonesian National Private Defense Industries (Pinhantanas) to Build the Independence of the Defense Industry
Authors: Nurfitriani Wulan , Nugroho Vicky , Deksino G. Royke 
Published: September 2023

The fact that the empowerment of the private defense industry needs to be improved. This is indicated by the problems that still exist in the defense industry, namely the lack of government commitment to increasing collaboration between State-Owned Strategic Industry Enterprises and Private-Owned Enterprises, and many domestic defense industry products that are still imported. This also raises the question, has the private defense industry not fulfilled the local market opportunity? Has the private defense industry yet to fulfill the Domestic Component Level (TKDN) obligation in producing the defense systems? Has the private defense industry yet to cooperate with the foreign defense industry? A literature study method underpins this research, offering the researchers a profound understanding of the Association of Indonesian National Private Defense Industries (Pinhantanas) empowerment. Employing this methodology, insights into defense industry challenges and the Association of Indonesian National Private Defense Industries are revealed. Hence, an investigation into Empowering the Association of Indonesian National Private Defense Industries to Augment Defense Industry Independence proves pivotal. By dissecting defense industry challenges using three research questions, this research offers insights and recommendations to empower the Association of Indonesian National Private Defense Industries (Pinhantanas).
PENGEMBANGAN MUARA KEDURANG MENJADI TEMPAT WISATA
Authors: Fitri Nabillah Awliya , Nahdah Alya Ghaitsa , Syarani Alinna Puspha , Sari Ratna Mustika , Sholeh Edo Imani , Purnama Ali Purnama , Siagian Teddy Alfra 
Published: September 2023

Kegiatan Kuliah Kerja Nyata (KKN) merupakan salah satu bentuk kegiatan pengabdian pada masyarakat yang dilaksanakan oleh mahasiswa sekaligus sebagai bagian dari perwujudan pelaksanaan Tri Dharma Perguruan Tinggi. Kuliah Kerja Nyata (KKN) Universitas Bengkulu Periode 97 Tahun 2022 dilaksanakan mulai tanggal 1 Juli s.d 16 Agustus 2022. Kuliah Kerja Nyata (KKN) merupakan salah satu bentuk pengabdian mahasiswa kepada masyarakat. Salah satu program kerja dalam pengabdian ini adalah Pengembangan Muara Kedurang Menjadi Tempat Wisata. Program kerja ini bertujuan untuk mengembangkan kembali tempat wisata muara dan pantai yang telah lama vakum akibat pandemi Covid-19. Metode pelaksanaan kegiatan ini dilakukan dengan cara menambah pembuatan gapura, penunjuk arah jalan, serta terjun langsung membantu desa dalam proses pengukuhan POKDARWIS.
Kata Kunci: KKN, Pariwisata, Desa Tanjung Aur

ABSTRACT
THE DEVELOPMENT OF THE KEDURANG ESTUARY INTO A TOURISM PLACE. KKN is a form of community service activity carried out by students as well as part of the realization of the implementation of the Tri Dharma of Higher Education. Bengkulu University Real Work Lecture (KKN) Period 97 of 2022 will be held from July 1 to August 16, 2022. Real Work Lecture (KKN) is a form of student service to the community. One of the work programs in this service is the Development of Muara Kedurang into a Tourism Place. This work program aims to redevelop estuary and beach tourist attractions that have long been vacuumed due to the Covid-19 pandemic. The method of implementing this activity is done by adding the construction of gates, and road signs, and directly helping the village in the POKDARWIS inauguration process.
Keywords: KKN, Tourism, Tanjung Aur Village
Aplikasi Game Edukasi Matematika dan Bahasa Inggris bagi Anak Sekolah Dasar
Authors: Pratama Yudha Hady , Rijati Nova 
Published: September 2023

Abstrak Perkembangan teknologi informasi telah mengubah pola dan sistem pembelajaran konvensional menjadi inovatif menggunakan game edukasi. Tujuan penelitian ini yaitu mengembangkan game edukasi mata pelajaran matematika dan bahasa Inggris bagi anak usia dini umur 6-8 tahun. Penelitian menggunakan model Multimedia Development Life Cycle (MDLC) dan metode Finite State Machine yang diterapkan pada game dengan tambahan multimedia serta efek-efek tertentu menjadikan game menjadi lebih menarik dan menyenangkan untuk dimainkan. Hasil penelitian menunjukkan bahwa game edukasi sebagai media pembelajaran memudahkan anak usia dini umur 6-8 tahun untuk memahami materi matematika dan bahasa Inggris sehingga meningkatkan motivasi dan semangat untuk selalu belajar. Kata Kunci: bahasa inggris, finite state machine, game edukasi, matematika AbstractDevelopment of information technology has changed conventional learning patterns and systems to become innovative by using educational games. The purpose of this study is to develop educational games in mathematics and English for early childhood ages 6-8 years. The research uses the Multimedia Development Life Cycle (MDLC) model and the Finite State Machine method which is applied to games with additional multimedia and certain effects that make games more interesting and fun to play. The results of the study show that educational games as learning media make it easier for young children aged 6-8 years to understand math and English material so as to increase motivation and enthusiasm to always learn. Keywords: english, finite state machine, game education, mathematics
Electronic health record-wide association study for atrial fibrillation in a British cohort
Authors: Chung Sheng-Chia , Schmit Amand F. , Lip Gregory Y. H. , Providencia Rui 
Published: September 2023

BackgroundAtrial fibrillation (AF) confers a major healthcare burden from hospitalisations and AF-related complications, such as stroke and heart failure. We performed an electronic health records-wide association study to identify the most frequent reasons for healthcare utilization, pre and post new-onset AF.MethodsProspective cohort study with the linked electronic health records of 5.6 million patients in the United Kingdom Clinical Practice Research Datalink (1998–2016). A cohort study with AF patients and their age-and sex matched controls was implemented to compare the top 100 reasons of frequent hospitalisation and primary consultation.ResultsOf the 199,433 patients who developed AF, we found the most frequent healthcare interactions to be cardiac, cerebrovascular and peripheral-vascular conditions, both prior to AF diagnosis (41/100 conditions in secondary care, such as cerebral infarction and valve diseases; and 33/100 conditions in primary care), and subsequently (47/100 conditions hospital care and 48 conditions in primary care). There was a high representation of repeated visits for cancer and infection affecting multiple organ systems. We identified 10 novel conditions which have not yet been associated with AF: folic acid deficiency, pancytopenia, idiopathic thrombocytopenic purpura, seborrheic dermatitis, lymphoedema, angioedema, laryngopharyngeal reflux, rib fracture, haemorrhagic gastritis, inflammatory polyneuropathies.ConclusionOur nationwide data provide knowledge and better understanding of the clinical needs of AF patients suggesting: (i) groups at higher risk of AF, where screening may be more cost-effective, and (ii) potential complications developing following new-onset AF that can be prevented through implementation of comprehensive integrated care management and more personalised, tailored treatment.Clinical trial registrationNCT04786366
Antihypertensive treatment with hydrochlorothiazide-hydralazine combination aggravates medial vascular calcification in CKD rats with mineral bone disorder
Authors: Larivière Richard , Ung Roth-Visal , Picard Sylvain , Richard Darren E. , Mac-Way Fabrice , Agharazii Mohsen 
Published: September 2023

BackgroundArterial stiffness and medial vascular calcification, leading to isolated systolic blood pressure (BP), are major cardiovascular risk factors in patients with chronic kidney disease (CKD) and mineral bone disorders (MBD). The impact of BP on MBD-induced medial vascular calcification in CKD remains uncertain. We investigated whether BP reduction improves arterial stiffness and medial vascular calcification in a rat model of CKD-MBD.MethodsCKD was induced in Wistar rats by subtotal nephrectomy. Then, MBD was generated by a Ca/P-rich diet with calcitriol supplementation to induce medial vascular calcification. Two antihypertensive treatments were evaluated: (1) the angiotensin AT1 receptor antagonist losartan, and (2) the combination of the thiazide diuretic hydrochlorothiazide and the direct vasodilator hydralazine (HCTZ/HY). After 5 weeks, mean BP (MBP), pulse pressure (PP), and pulse wave velocity (PWV) were determined. Vascular calcification was assessed in the thoracic aorta.ResultsWhile MBP was similar in CKD-MBD and control CKD rats, PP and PWV were increased in CKD-MBD rats. The heightened arterial stiffness in CKD-MBD rats was associated with diffused medial calcification along the thoracic aorta. Although both losartan and HCTZ/HY reduced MBP in CKD-MBD rats, losartan did not affect PP and PWV nor medial vascular calcification, whereas HCTZ/HY, unexpectedly, further increased arterial stiffness and medial vascular calcification.ConclusionIn the rat model of CKD-MBD, antihypertensive treatment with losartan did not affect arterial stiffness or medial vascular calcification. However, HCTZ/HY treatment aggravated arterial stiffness and vascular calcification despite a similar reduction of MBP, suggesting a blood pressure-independent mechanism for vascular calcification.
Integration of scRNA-Seq and bulk RNA-Seq uncover perturbed immune cell types and pathways of Kawasaki disease
Authors: Cao Naixin , Ouyang Huayi , Zhang Xing , Xu Yuanyuan , Li Jun , Chen Yanfei 
Published: September 2023

IntroductionKawasaki disease (KD) is an acute febrile illness primarily affecting children and characterized by systemic inflammation and vasculitis that can lead to coronary artery complications. The aim of this study was to gain a comprehensive understanding of immune dysregulation in KD.MethodsTo this end, we employed integration of single-cell RNA sequencing (scRNA-Seq) and bulk RNA sequencing (bulk RNA-Seq) data. Furthermore, we conducted flow cytometry analysis for a cohort of 82 KD patients.ResultsOur analysis revealed significant heterogeneity within immune cell populations in KD patients, with distinct clusters of T cells, B cells, and natural killer (NK) cells. Importantly, CD4+ naïve T cells in KD patients were found to predominantly differentiate into Treg cells and Th2 cells, potentially playing a role in the excessive inflammation and vascular damage characteristic of the disease. Dysregulated signaling pathways were also identified, including the mTOR signaling pathway, cardiomyopathy pathway, COVID-19 signaling pathway, and pathways involved in bacterial or viral infection.DiscussionThese findings provide insights into the immunopathogenesis of KD, emphasizing the importance of immune cell dysregulation and dysregulated signaling pathways. Integration of scRNA-Seq and bulk RNA-Seq data offers a comprehensive view of the molecular and cellular alterations in KD and highlights potential therapeutic targets for further investigation. Validation and functional studies are warranted to elucidate the roles of the identified immune cell types and pathways in KD pathogenesis and to develop targeted interventions to improve patient outcomes.
The long-term outcomes of the Anderson-Kestenbaum procedure
Authors: Kuziel Jeffrey , Pope Hannah , Kothapalli Aishwarya J. , Larson Scott A. , Drack Arlene , Dumitrescu Alina V. 
Published: September 2023

IntroductionNystagmus is an involuntary, conjugated, rhythmic movement of the eye that can be idiopathic or secondary to ocular or neurologic pathologies. Patients with nystagmus often have a position of gaze in which their symptoms are dampened or absent, referred to as the “null zone.” The Anderson-Kestenbaum procedure is a bilateral recess-resect procedure of the four horizontal rectus muscles which aims to bring the null position into the primary gaze. This study aims to further elucidate long-term outcomes and factors associated with optimal postoperative outcomes.MethodsPatients with a diagnosis of nystagmus and a surgical code for strabismus between June 1990 and August 2017 were considered for inclusion in the study. Patients were included if they had undergone the Anderson-Kestenbaum procedure and had follow-up lasting at least 24 months post-operatively. Data collected included demographic information, characteristics of the nystagmus, underlying etiology of nystagmus, and pre-and post-operative measurements.Results25 patients were included. At their last recorded follow-up, 44% of patients achieved an optimal surgical outcome -an abnormal head position of 10 degrees or less. 88% of patients showed an overall improvement in their head posture at the last follow-up. The absence of an abnormal head position at the visit closest to 24 months post-operatively was found to be significantly associated with the lack of a significant head position at the last follow-up visit. Optimal surgical outcomes were not significantly associated with the underlying diagnosis, the direction of the abnormal head position, or the type of nystagmus.DiscussionThe relatively long follow-up of this cohort allows this study to further elucidate the long-term outcomes of the Anderson-Kestenbaum procedure. Overall, our results suggest that although improvement in head position post-operatively is likely, it is still expected that many patients will have a residual abnormal head position after the procedure. The results of this study are helpful in counseling patients, especially knowing that if they do not have a significant head position at 24 months follow-up, they are unlikely to develop one. However, due to the small sample size, larger cohorts and more standardized follow-up may provide further insight into the procedure’s outcomes.