bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of nerve block anesthesia and local infiltration anesthesia with lidocaine hydrochloride in primary root canal treatment of mandibular molars
Authors: Geng Shuangshuang , Wang Jian , Bai Xiaobei , Hou Yan , Li Junke , Ban Jiandong 
Published: May 2023

Purpose: To investigate and compare the analgesic effects of nerve block anesthesia and local infiltration anesthesia in one-visit root canal therapy of mandibular molars.
Methods: A total of 120 patients who underwent one-visit root canal therapy for mandibular molars were divided into nerve block group (n = 76) and local infiltration group (n = 44). Lidocaine was used to anesthetize the two groups. Perioperative heart rate (HR), diastolic blood pressure (DBP) and systolic blood pressure (SBP) were determined in the two groups. Visual analogue scale (VAS) and Ramsay sedation scale were used to assess postoperative pain and sedation in the two groups. The occurrence of adverse reactions was also compared.
Results: The success rate of the anesthesia in the nerve block group was significantly higher than that in local infiltration group (9 7.37 vs 88.64 %; p < 0.05). There were no significant differences in HR, DBP and SBP levels between the two groups. Over time, VAS and Ramsay scores decreased in both groups, while the VAS and Ramsay scores in the nerve block group were significantly lower than those in the local infiltration group (p < 0.05). The incidence of adverse reactions in the nerve block group was 5.26 %, which was not significantly different from 13.64 % incidence rate in local infiltration group (p > 0.05).
Conclusion: Both anesthesia methods have little effect on hemodynamics in patients undergoing one-visit root canal therapy for mandibular molars, but lidocaine nerve block anesthesia is more effective and has stronger analgesic and sedative effects than lidocaine local infiltration anesthesia.
Entecavir/peginterferon alfa-2a combination in the treatment of two genotypes of chronic hepatitis B patients with lamivudine resistance
Authors: Peng Xiaoyun , Chen Longgui , Xiao Mingying 
Published: May 2023

Purpose: To investigate the efficacy of entecavir plus peginterferon alfa-2a in the treatment of chronic hepatitis B (CHB) patients with different hepatitis B virus (HBV) genotypes resistant to lamivudine (LAM).
Methods: 119 LAM-resistant CHB patients treated in Baoshan People's Hospital from May 2018 to May 2020 were selected. All patients received entecavir and peginterferon alfa-2a for 24 months and were scheduled for regular outpatient review and telephone follow-up. Polymerase chain reaction (PCR) was conducted to determine the HBV genotype and HBV-DNA clearance. Alanine aminotransferase (ALT) normalization rate, HBV-DNA clearance rates, and hepatitis B e-antigen (HBeAg) seroconversion rate were determined in CHB patients with different genotypes. Quality of life for all patients was assessed using SF-36 Scale.
Results: Five out of 119 patients were lost during follow-up, with a follow-up rate of 95.80 %. Two HBV genotypes were identified, of which 42 (36.8 %) were type B and 72 (63.2 %) type C. At the 6th and 12th month of follow-up, the HBV-DNA clearance rate, ALT normalization rate, and HBeAg seroconversion rate were significantly higher in CHB patients with genotype B than in patients with genotype C (p < 0.05). There were no significant differences between the three rates in the two groups at 18th and 24th month of follow-up (p > 0.05). The quality of life (QOL) of the patients differed between the two groups (p < 0.05).
Conclusion: Entecavir plus peginterferon alfa-2a are effective in treating LAM-resistant CHB patients with different genotypes. Genotype B CHB patients are more suitable for this combination protocol.
Anesthetic effect of sufentanil in patients undergoing cardiovascular surgery
Authors: Yuan Cheng , Wang Dan , Cheng Qing 
Published: May 2023

Purpose: To investigate the effect of sufentanil on anesthesia in patients undergoing cardiovascular surgery.
Methods: The subjects comprised a total of 100 patients who were scheduled to undergo cardiovascular surgery in Taikang Tongji (Wuhan) Hospital from January 2021 to December 2021 and met the inclusion criteria. The eligible patients were assigned in a ratio of 1:1 to receive either remifentanil (control group) or sufentanil (study group) during cardiovascular surgery, with 50 patients in each group. The anesthetic effect of remifentanil and sufentanil was compared.
Results: Patients treated with sufentanil experienced a faster onset of anesthesia and a shorter time-lapse before extubation, postoperative spontaneous breathing recovery, and postoperative anesthesia recovery when compared with those administered with remifentanil (p < 0.05). Sufentanil provided more potent pain mitigation for patients undergoing cardiovascular surgery than remifentanil, as shown by the lower visual analogue scale (VAS) scores of patients in the study group (p < 0.05). Patients administered with sufentanil showed better levels of mean arterial pressure (MAP) and oxygen saturation (SpO2) than remifentanil, suggesting better hemodynamic benefits provided by sufentanil (p < 0.01). During cardiovascular surgery performed in this study, sufentanil resulted in a higher safety profile by reducing significantly the incidence of adverse reactions (6 %) than remifentanil (30 %) (p < 0.01).
Conclusions: Sufentanil exhibits a better anesthetic effect in patients undergoing cardiovascular surgery than remifentanil. It provides potent pain mitigation, effectively ameliorates patients’ hemodynamic status, and reduces the risk of adverse reactions. Future studies with larger sample sizes are required to validate these findings.
HMGB1-mediated-TLR4/MyD88 signaling regulates cell proliferation, migration and invasion in esophageal squamous cell carcinoma
Authors: Liang Xuyang , Ma Yanqin , Zhang Zhimei , Xu Dazhou , Lv Shengxiang , He Yanling , Zhang Shuxian , Ren Ling , Xu Ping 
Published: May 2023

Purpose: To study the effect of high mobility group box protein 1 (HMGB1)-mediated toll-like receptor 4 (TLR4)/myeloid differentiation factor 88 (MyD88) on esophageal squamous cell carcinoma (ESCC).
Methods: Cell viability was determined using CCK-8 test and colony formation assay, while cell migration and invasion were assessed by Transwell assay. Western blotting was used to determine protein and mRNA expression levels. The effect of TLR4/MyD88 signaling pathway on proliferation of ESCC cells was investigated via in vitro knockdown of HMGB1.
Results: Data from in vitro experiments indicated that HMGB1 knockdown significantly decreased the proliferation, migration, and invasion of EC9706 cells in siHMGB1 group, when compared with siNC group (number of invasive cells in siHMGB1 vs. corresponding number in siNC: 26.7 ± 4.5 vs. 68.7 ± 2.5; p < 0.01), and also decreased proliferation, migration and invasion of TE-9 cells in siHMB1, relative to siNC group (number of invasive cells in siHMGB1 vs. corresponding number in siNC: 29.3 ± 3.5 vs. 55.7 ± 3.1; p < 0.01). Moreover, MGB1 knockdown via siTLR4 transfection significantly down-regulated the expressions of TLR4/MyD88 and epithelial-mesenchymal transition (EMT), but over-expression of TLR4 reversed the inhibition by HMGB1 knockdown on ESCC cells (p < 0.01).
Conclusion: These findings suggest that HMGB1-mediated TLR4/MyD88 signal pathway is a potential treatment route for ESCC.
Long non-coding RNA reprogramming (LncRNA-ROR) attenuate inflammation induced by LPS through the regulation of miRNA-124-3p and inhibition of C5a and TLR4/Myd88/NF-κB pathwaysin C28/12 cells
Authors: Lu Wei , Yao Jing , Cheng Yu , Mao Dongmei , Luo Di , Wang Lin 
Published: May 2023

Purpose: Osteoarthritis (OA), inflammation of joint and articular cartilage, is a serious joint disorder and a major cause of pain and disability. LncRNAs exert their role in OA progression. The purpose of this present research is to investigate the impact and molecular mechanism of lncRNA regulator of reprogramming (LncRNA-ROR) on inflammatory damage induced by lipopolysaccharide (LPS) in C28/12 cells.
Methods: The expressions of lncRNA-ROR and miR-124-3p and the mRNA expressions of COX-2, iNOS, IL-8, C5a, and TNF-α were determined in C28/12 cells stimulated with LPS using RT-qPCR. Viability of C28/12 cells was evaluated using CCK-8 assay and C28/12 cell apoptosis was assessed by flow cytometry in LPS-induced C28/12 cells. Moreover, the concentration of IL-8, C5a, and TNF-α and the protein expressions of TLR4/Myd88/NF-κB pathways were examined using Elisa assay.
Results: Results revealed that LPS inhibited the proliferation, enhanced rate of cell apoptosis, and promoted mRNA expressions of iNOS, IL-8, C5a, and TNF-α in C28/12 cells. Besides, the expression of lncRNA-ROR was expressively reduced in C28/12 cells stimulated with LPS and the lncRNA-ROR overexpression markedly reduced the inflammatory injury stimulated by LPS in C28/12 cells. Besides, lncRNA-ROR significantly down-regulated the miR-124-3p expression and miR-124-3p exposure inhibited the protecting impact of lncRNA-ROR on LPS-induced C28/12 cells. Furthermore, lncRNA-ROR suppressed the TLR4/Myd88/NF-κB pathways via suppressing the expression of miR-124-3p in LPS-induced C28/12 cells.
Conclusion: The finding revealed that lncRNA-ROR protected against LPS-stimulated inflammatory injury in C28/12 cells by suppressing TLR4/Myd88/NF-κB pathways via inhibiting miR-124-3p suggested an efficient therapeutic strategy for OA treatment.
Báo cáo loạt ca: bướu sợi vỏ bào buồng trứng
Authors: Nguyễn Huỳnh Ngọc Tân , Nguyễn Hồng Hoa 
Published: May 2023

Mở đầu: Bướu sợi vỏ bào nằm trong nhóm bướu mô đệm-dây giới bào của buồng trứng, chiếm tỷ lệ thấp trong nhóm bướu tân sinh của buồng trứng. Bướu có dạng đặc và lành tính nhưng chẩn đoán trước phẫu thuật thường là bướu buồng trứng ác tính, dẫn đến những can thiệp chưa phù hợp.
Nghiên cứu này nhằm mục tiêu: Khảo sát những đặc điểm lâm sàng, cận lâm sàng và can thiệp điều trị của bướu sợi vỏ bào.
Đối tượng và Phương pháp: Báo cáo loạt ca hồi cứu 89 trường hợp bướu sợi vỏ bào đã được phẫu thuật cắt bướu từ 1/2015 đến 6/2019 tại Bệnh viện Từ Dũ với kết quả giải phẫu bệnh lý bướu sợi vỏ bào buồng trứng.
Kết quả: Tuổi trung bình của các bệnh nhân trong nhóm nghiên cứu là 42,2 ± 15,7. Khoảng 41,57% bệnh nhân không có triệu chứng và đi khám định kỳ được bác sĩ sờ thấy bướu trong 80 trường hợp và một số rất ít trường hợp có kèm theo dấu hiệu báng bụng đơn thuần (1 trường hợp), dấu hiệu nghi u xoắn (2 trường hợp) và hội chứng Meigs (1 trường hợp), phát hiện khối u trong quá trình mổ lấy thai 2 trường hợp. Trên siêu âm, đặc điểm khối u phần lớn có cấu trúc dạng đặc (30 trường hợp) nhưng lại chỉ có 1 trường hợp u 2 bên, 17 trường hợp có tăng sinh mạch máu và 1 tới 2 trường hợp có chồi hay vách. Có 49 trường hợp theo phân loại IOTA được xếp vào nhóm khác với 38 trường hợp được nhận định là u xơ cơ tử cung. Có 14 trường hợp (15,73%) có chẩn đoán trước mổ là bướu buồng trứng ác tính qua hình ảnh siêu âm và cộng hưởng từ (MRI). Nồng độ CA125 trong huyết thanh của 29 trường hợp tăng cao, và có liên quan có ý nghĩa với tình trạng có hình ảnh dịch ổ bụng (p < 0,001). Phần lớn bệnh nhân được thực hiện là mổ bụng hở, thám sát khối u và dựa theo hình ảnh đại thể để quyết định phương pháp phẫu thuật. Trong các trường hợp có sinh thiết lạnh thì kết quả dẫn đường luôn là bướu lành tính.
Kết luận: Bướu sợi vỏ bào buồng trứng thường bị chẩn đoán trước mổ là u xơ cơ tử cung, bệnh lý lành tính hoặc ngược lại là bệnh ác tính - buớu buồng trứng ác tính. Để chẩn đoán chính xác trước mổ là bướu sợi vỏ bào buồng trứng cần thêm những nghiên cứu tiền cứu tìm kiếm các phương pháp tiếp cận khối u chính xác hơn và vai trò của sinh thiết lạnh trong quá trình phẫu thuật thám sát bản chất khối u trước khi có can thiệp phẫu thuật.
Thực trạng tử vong mẹ và các yếu tố liên quan tại 31 tỉnh phía Bắc giai đoạn 2019 - 2021
Authors: Trần Danh Cường , Phạm Duy Duẩn , Nguyễn Thị Huyền Linh , Phạm Văn Chung , Trịnh Thị Thúy Hằng , Hoàng Thị Nguyên , Vũ Thị Thanh Thủy , Trần Thị Hiền 
Published: May 2023

Mục tiêu: Mô tả tình hình, nguyên nhân tử vong mẹ (TVM) và các yếu tố liên quan đến tử vong mẹ tại 31 tỉnh phía Bắc 3 năm 2019 - 2021.
Đối tượng và phương pháp nghiên cứu: Nghiên cứu hồi cứu biên bản thẩm định của 154 bà mẹ tử vong (BMTV) tại 31 tỉnh phía Bắc năm 2019 - 2021.
Kết quả: Tổng số ca tử vong của khu vực phía Bắc là 206 ca, đã thẩm định là 154 ca chiếm 74,8%. Trong 154 hồ sơ được thẩm định: nguyên nhân tử vong trực tiếp 63%, trong đó nguyên nhân chảy máu sau đẻ nhiều nhất trong nhóm này 50,5%. Chậm 1 - chậm phát hiện các dấu hiệu bất thường và tìm đến cơ sở y tế chiếm tỷ lệ cao nhất với 63%. 83,8% trường hợp tử vong có một yếu tố chậm hoặc phối hợp nhiều yếu tố chậm trễ. Có mối liên quan có ý nghĩa thống kê giữa các yếu tố chậm trễ, thời điểm tử vong với nguyên nhân tử vong mẹ. Kết luận: Nguyên nhân tử vong mẹ liên quan đến chậm 1 là nhiều nhất, 83,8% trường hợp tử vong có một yếu tố chậm hoặc phối hợp nhiều yếu tố chậm trễ.
Khuyến nghị: Truyền thông đến đối tượng phụ nữ trước và trong độ tuổi sinh đẻ chăm sóc thai nghén, cách phát hiện dấu hiệu bất thường, đẻ tại CSYT… Đồng thời nâng cao năng lực ở các CSYT các tuyến. Công tác khám và quản lý thai nghén từ trạm y tế xã trở lên cần được chú trọng, phát hiện sớm các dấu hiệu bất thường, có thái độ xử trí đúng đắn, kịp thời.
Khảo sát kết cục thai kỳ và chuyển dạ ở những thai phụ mang thai con so từ 37⁺⁰ đến 41⁺⁶
Authors: Nguyễn Trần Thảo Nguyên , Lê Trương Quỳnh Giang , Trần Doãn Tú 
Published: May 2023

Mở đầu: Hiện nay, các bằng chứng cho thấy kết cục thai kỳ nhóm thai đủ tháng có thể khác nhau khi phân tích so sánh trong phạm vi mỗi tuần tuổi thai. Các nghiên cứu gần đây chỉ ra rằng ở đối tượng sản phụ mang thai con so có nguy cơ thai kỳ thấp, chuyển dạ ở tuần 39 của thai kỳ không làm giảm đáng kể tỷ lệ biến chứng chu sinh nhưng làm giảm đáng kể tỷ lệ sinh mổ.
Mục tiêu: Khảo sát kết cục thai kỳ và chuyển dạ ở những thai phụ mang thai con so từ 37+0 đến 41+6.
Đối tượng và phương pháp nghiên cứu: Nghiên cứu mô tả cắt ngang trên 388 sản phụ mang thai con so chuyển dạ từ 37+0 đến 41+6 tại Bệnh viện Trường Đại học Y - Dược Huế từ tháng 8/2021 đến tháng 4/2022.
Kết quả: Có sự khác biệt BMI trước mang thai và tăng cân trong thai kỳ ở các nhóm sản phụ. Tỷ lệ sản phụ nước ối màu xanh và CTG nhóm III có xu hướng tăng ở nhom thai quá ngày sinh dự đoán. Mổ lấy thai có tỷ lệ tăng dần theo tuần thai chuyển dạ sinh (p < 0,05). Nhóm sản phụ chuyển dạ sinh ở tuần thai 400-6 có nguy cơ mổ lấy thai cao gấp 2,91 lần so với nhóm sản phụ chuyển dạ sinh ở tuần thai 390-6. Điểm số Apgar phút 1 dưới 8 điểm gặp cao nhất ở nhóm chuyển dạ sinh tuần thai nhỏ hơn 380-6. Số trường hợp theo dõi tại NICU chủ yếu ở nhóm dưới 380-6 và nhóm 410-6.
Kết luận: Chuyển dạ sinh ở tuần thai 390-6 có tỷ lệ mổ lấy thai thấp hơn so với các tuần thai khác. Nhóm thai quá ngày sinh tăng có ý nghĩa tỷ lệ nước ối có phân su, CTG nhóm III và tỷ lệ con to.
Simultaneous two-stage surgical treatment for Chiari malformation association with occlusive hydrocephalus: a clinical case
Authors: Kositov D. D. , Rahmonov Kh. J. , Berdiev R. N. , Turdiboev Sh. A. , Davlatov M. V. , Rahmonov U. Kh. 
Published: May 2023

Treatment of patients with the simultaneous presence of Chiari malformation type I (MC I) and hydrocephalus may include both one-stage and two-stage surgical interventions. The article describes the two-stage surgical treatment experience performed for the first time in the Republic of Tajikistan. Description of the case. A 50-year-old female patient with a three-year history of bursting headache, dizziness, nausea, and vomiting developed impaired coordination of movements and decreased visual acuity. Computed tomography (CT) revealedsigns of MC I: descent of the cerebellar tonsils 5 mm below the level of the foramen magnum and occlusive triventricular hydrocephalus with symmetrical enlargement of the lateral and third ventricles. The patient underwent surgery – endoscopic third ventriculocisternostomy (ETV) in combination with decompressive suboccipital craniectomy, which was supplemented by CI laminectomy. After the surgery, the symptoms regressed. According to the control CT scan, there was a moderate decrease in the size of the lateral and third ventricles, restoration of the normal anatomical structure of the posterior cranial fossa.
Kedudukan Keuangan Negara Dalam Badan Usaha Milik Negara
Authors: Salmon Harly Clifford Jonas 
Published: May 2023

Introduction: The state separates its finances to be used as capital in state-owned enterprises. However, Law Number 17 of 2003 concerning State Finances still counts the separated capital as state finance, contrary to the principle that separated finance is corporate finance.Purposes of the Research: Analyzing the Position of State Financial Status in State-Owned Enterprises. Methods of the Research: The research method used is normative juridical, with a statutory and conceptual approach. The sources of legal materials used are primary, secondary, and tertiary legal materials. The technique of collecting legal materials carried out in this research is through literature study.Results of the Research: The results of the study show that state finances are all rights attached to the state in the form of money or goods, including equity participation in state-owned enterprises. However, in its management, when the capital has been handed over to a state-owned enterprise, the state's financial status has completely changed to private finance, in this case it is a state-owned enterprise in accordance with Article 4 paragraph (1) UUBUMN which states that the company's capital comes from separated state assets. This capital in the legal context of the company is equity capital. Pursuant to the provisions of Article 1 point 7 of Government Regulation Number 72 of 2016 concerning Procedures for Participation and Administration of State Capital in BUMN and Limited Liability Companies, state capital participation is the separation of State assets from the APBN or determination of company reserves or other sources to serve as BUMN capital and/or other limited liability companies are managed as a corporation. has also been explained in the Constitutional Court Decision No. 77/PUU-IX/2011. The Constitutional Court ruled that a BUMN is a business entity that has separate assets from state assets so that the authority to manage business assets, including the settlement of BUMN debts, is subject to the limited liability company law. This is the point of privatization of state finances which are included in state-owned enterprises where the capital is then managed by the business entity with business principles.
A Review of the Essence of Stability Constants in the Thermodynamic Assessments of Chemical Compounds
Authors:   Department of Chemistry, Federal University of Technology, Owerri, Nigeria, Ogechi Onyeocha Veronica , Ikejiofor Onuchukwu Anthony ,   Department of Chemistry, Chukwuemeka Odumegwu Ojukwu University, Uli Campus Anambra, Nigeria
Published: May 2023

Background: This treatise discusses the following topics: •	Chemical compounds •	Factors affecting stability of chemical compounds •	Stability constants •	The significance of stability constants vis-a-vis equilibrium constant, Keq The different forms of stability constant are reviewed and the thermodynamic assessment of stability constant is explained. Method: The approach involved the review from reputable authors and writers, of the topics that are associated with stability constant and the generalization is remarked following the thermodynamic assessment of the stability constant of chemical compounds. Findings: The thermodynamic analysis of stability constant of chemical compounds and of reactions shows that reactions proceed in the direction of decreasing Gibb’s free energy, G, where the standard reaction Gibb’s free energy, ∆rG0 = ∆fG0 (B) - ∆fG0 (A), defines the formation of the pure substance B, from the pure substance A, at its standard state. Conclusion: RTlnK = -∆r G0 is the link between thermodynamic data and the equilibrium constant (stability constant), K. When ∆r G0 > 0, K < 1 and at equilibrium the partial pressure of A exceeds that of B. This means that the reactant A is favored in the equilibrium. When ∆r G0 < 0, K > 1 and at the equilibrium the partial pressure of B exceeds that of A. The product B is favored in the equilibrium. The equation is an exact thermodynamic relation. The equilibrium constant, K, when expressed in terms of activities, is called a thermodynamic equilibrium constant
General Practitioners Involvement in Public Health Infectious Disease Surveillance, District of Kota Kinabalu: A Brief Descriptive Study
Authors: Musiun Aldrin Alexander 
Published: May 2023

Background: Infectious disease remains a public health concern in Malaysia. Efficient public health infectious disease surveillance is needed in order to address the issues posed by infectious disease. The main goal of public health infectious disease surveillance is to facilitate the control and prevention of the infectious diseases. For that, infectious disease surveillance needs involvement of multidiscipline either in government or non-government/private to ensure its success. General practitioners (GPs) have an important role in public health infectious disease surveillance considering their role and position as one of the main front liner medical personnel.
Keywords: general practitioners, public health, infectious disease, surveillance
Early Stages of Global Neurosurgery
Authors: Johnson Walter D , Rubiano Andres , Osorio Enrique 
Published: May 2023

The year 2015 was pivotal for the growth of global neurosurgery. In January, the United Nations (UN) adopted the Sustainable Development Goals (SDGs), replacing the expiring Millennial Development Goals. The SDGs were more comprehensive, having 17 Goals with 169 associated targets; a significant number of these included the necessity for surgical care to achieve the targets. 1
In early Spring 2015, publication of Global Surgery 2030: evidence and solutions for achieving health, welfare, and economic development - The Lancet Commission on Global Surgery created a paradigm shift in the understanding of surgical needs worldwide, particularly in access to safe, timely and affordable surgical care for billions of individuals and large gaps in global surgical health workforce.2 At around the same time, Disease Control Priorities 3rd Edition, Volume 1, Essential Surgery laid out the economic case for surgical care, particularly in low resource settings.3 In May, the 68th World Health Assembly unanimously approved WHA resolution 68.15 on strengthening emergency and essential surgical care as a component of universal health coverage.4
The adoption of SDGs and WHA 68.15 provided the political impetus toward making surgical care a global priority, DCP3 created the health economic basis for global surgical care, and the Lancet Commission developed the factual needs basis for greatly enlarging global surgical service delivery.
The World Health Organization (WHO) is the health technical arm of the UN. The WHA is composed of the health ministers of all UN Member States (countries) and is the governing body of WHO, setting the global health agenda and steering WHO’s work. The WHO Emergency and Essential Surgical Care (EESC) Programme5 was given the mandate to implement WHA resolution 68.15; a task that could only be achieved through extensive worldwide partnerships, such as the World Federation of Neurosurgical Societies (WFNS), which has official working relations as a non-state actor with WHO.6
September 9-12, 2015, the 15th Interim Meeting of the World Federation of Neurosurgical Societies (WFNS) met in Rome, Italy.7 For the first time, a neurosurgeon was Lead of WHO EESC, creating a unique opportunity for optimally augmenting this WHO/WFNS partnership going forward. The Foundation for International Education in Neurosurgery (FIENS) held a session during this meeting, further highlighting future prospects.