bluuebunny/crossref_metadata_2025_split huggingface dataset:
Current Advances on the Single‐Atom Nanozyme and Its Bioapplications
Authors: Peng Chao , Pang Ruoyu , Li Jing , Wang Erkang 
Published: February 2023

AbstractNanozymes, a class of nanomaterials mimicking the function of enzymes, have aroused much attention as the candidate in diverse fields with the arbitrarily tunable features owing to the diversity of crystalline nanostructures, composition, and surface configurations. However, the uncertainty of their active sites and the lower intrinsic deficiencies of nanomaterial‐initiated catalysis compared with the natural enzymes promote the pursuing of alternatives by imitating the biological active centers. Single‐atom nanozymes (SAzymes) maximize the atom utilization with the well‐defined structure, providing an important bridge to investigate mechanism and the relationship between structure and catalytic activity. They have risen as the new burgeoning alternative to the natural enzyme from in vitro bioanalytical tool to in vivo therapy owing to the flexible atomic engineering structure. Here, focus is mainly on the three parts. First, a detailed overview of single‐atom catalyst synthesis strategies including bottom‐up and top‐down approaches is given. Then, according to the structural feature of single‐atom nanocatalysts, the influence factors such as central metal atom, coordination number, heteroatom doping, and the metal–support interaction are discussed and the representative biological applications (including antibacterial/antiviral performance, cancer therapy, and biosensing) are highlighted. In the end, the future perspective and challenge facing are demonstrated.
Copper(II)‐Catalyzed Cascade Reactions of N‐Aryl Nitrones and Disubstituted Allenoates to Prepare [1,3]Oxazino[3,2‐a]indolines and Dihydropyrido[1,2‐a]indolines
Authors: Xu Pei‐Pei , Xin Su‐Ge , Li Xue , Liang Cui , Mo Dong‐Liang 
Published: February 2023

AbstractWe described a copper(II)‐catalyzed [3+2] cycloaddition of N‐aryl‐α,β‐unsaturated nitrones with disubstituted allenoates bifurcated to prepare various [1,3]oxazino[3,2‐a]indolines and dihydropyrido[1,2‐a]indolines in moderate to excellent yields. Mechanistic studies revealed that [1,3]oxazino[3,2‐a]indoline was a kinetically favored product and dihydropyrido[1,2‐a]indoline was thermodynamically favored product. Moreover, the reaction was easily performed at gram scales and chiral dihydropyrido[1,2‐a]indoline could be obtained by using chiral auxiliary. The present method highlights broad substrate scope, good functional group tolerance, and diversity of indoline scaffolds with high diastereoselectivity.magnified image
Hydrogel‐Based Multifunctional Soft Electronics with Distributed Sensing Units: A Review
Authors: Zhang Chuan Wei , Hao Xing Peng , Zheng Qiang , Wu Zi Liang 
Published: February 2023

AbstractSoft electronics have attracted great interest owing to their potential applications in electronic skins, implanted devices, soft robotics, etc. Among the various soft materials, hydrogels are recognized as an ideal building block of soft electronics due to their tissue‐like physicochemical properties, abundant stimuli‐responses, and excellent mechanical compliances. Compared to elastomers, hydrogels containing large amounts of water exhibit better mechanical match to soft tissues and permeability to hydrophilic molecules. To date, most hydrogel‐based soft electronics (HSE) are facilely developed using a bulk conductive gel as the sensing unit, different from the elastomer‐based soft electronics with sophisticated integration of electronic elements. To advance their applications in engineering and biomedical fields, it is significant to devise hydrogel electronics with distributed sensing units. This Review summarizes the fabrication and applications of HSE, focusing on the multifunctional HSE with patterned conductive circuits and distributed sensing units. First, the fabrication of single‐functional soft electronics is briefly introduced with a bulk gel as the building block, including strain, temperature, chemical, and proximity sensors. Then, the approaches to integrating multiple sensing units into one hydrogel are summarized with examples of applications. Finally, perspectives are given on future directions and potential challenges in this field.
Biopolymeric Coatings for Local Release of Therapeutics from Biomedical Implants
Authors: Talebian Sepehr , Mendes Bárbara , Conniot João , Farajikhah Syamak , Dehghani Fariba , Li Zhongyan , Bitoque Diogo , Silva Gabriela , Naficy Sina , Conde João , Wallace Gordon G. 
Published: February 2023

AbstractThe deployment of structures that enable localized release of bioactive molecules can result in more efficacious treatment of disease and better integration of implantable bionic devices. The strategic design of a biopolymeric coating can be used to engineer the optimal release profile depending on the task at hand. As illustrative examples, here advances in delivery of drugs from bone, brain, ocular, and cardiovascular implants are reviewed. These areas are focused to highlight that both hard and soft tissue implants can benefit from controlled localized delivery. The composition of biopolymers used to achieve appropriate delivery to the selected tissue types, and their corresponding outcomes are brought to the fore. To conclude, key factors in designing drug‐loaded biopolymeric coatings for biomedical implants are highlighted.
Rock around DYRK1A: Ethnic diversity, clinical challenges
Authors: Moroni Alice , Pezzani Lidia , Alfei Enrico , Scatigno Agnese , Cereda Anna , Marzaroli Michela , Guuva Claudia , Gabbiadini Sara , Pezzoli Laura , Marchetti Daniela , Spaccini Luigina , Iascone Maria 
Published: February 2023

AbstractDYRK1A‐related intellectual disability is a recently described syndrome characterized by microcephaly, global developmental delay, impaired speech development, and distinctive facial features, which let to define it as a recognizable syndrome. Here we report four new patients of different ethnicity, broadening the clinical phenotype of the condition and highlighting how ethnic influences in the facial appearance could make it less recognizable.
Akaike's Information Criterion for Stoichiometry Inference of Supramolecular Complexes
Authors: Ikemoto Koki , Takahashi Kanato , Ozawa Takeaki , Isobe Hiroyuki 
Published: February 2023

Abstract“How do we decide the stoichiometry of host–guest complexes?” This question has long been answered by the Job plot since its first report in 1928. However, as the Job plot was claimed to be misleading in 2016, the question became an open question again and called for renewed investigations. An information‐theoretic approach, called Akaike's information criterion, is introduced in this study to select the best model of host–guest complexes, which can rank the models with weight of evidence. A few test cases with unique cylindrical hosts were examined to demonstrate the applicability of the information‐theoretic method. Consequently, reasonable views over the thermodynamic behaviors of dumbbell‐and‐cylinder complexes were obtained. Akaike's information criterion can be a useful and superior alternative to statistical null hypothesis testing, which was proposed as a remedy in place of the Job plot.
Peptide‐mediated Aqueous Synthesis of NIR‐II Emitting Ag2S Quantum Dots for Rapid Photocatalytic Bacteria Disinfection
Authors: Sun Peiqing , Li Kunlun , Liu Xiao , Wang Jing , Qiu Xusheng , Wei Wei , Zhao Jing 
Published: February 2023

AbstractPathogenic microorganisms in the environment are a great threat to global human health. The development of disinfection method with rapid and effective antibacterial properties is urgently needed. In this study, a biomimetic silver binding peptide AgBP2 was introduced to develop a facile synthesis of biocompatible Ag2S quantum dots (QDs). The AgBP2 capped Ag2S QDs exhibited excellent fluorescent emission in the second near‐infrared (NIR‐II) window, with physical stability and photostability in the aqueous phase. Under 808 nm NIR laser irradiation, AgBP2‐Ag2S QDs can serve not only as a photothermal agent to realize NIR photothermal conversion but also as a photocatalyst to generate reactive oxygen species (ROS). The obtained AgBP2‐Ag2S QDs achieved a highly effective disinfection efficacy of 99.06 % against Escherichia coli within 25 min of NIR irradiation, which was ascribed to the synergistic effects of photogenerated ROS during photocatalysis and hyperthermia. Our work demonstrated a promising strategy for efficient bacterial disinfection.
Engineering Photosynthetic Microbial Consortia for Carbon‐Negative Biosynthesis
Authors: Wang Bo , Dai Zhuojun 
Published: February 2023

AbstractMicrobial consortia consisting of phototrophs and heterotrophs have raised extensive attention due to their potential in sustainable biotechnology. The challenge remains in the selection of appropriate partners since most heterotrophic microorganisms cannot naturally use the intermediate carbohydrates secreted by autotrophic partners. In a recent study, the Ni Lab has developed a highly compatible autotrophic‐heterotrophic symbiotic system comprising Synechococcus elongatus and Vibrio natriegens. V. natriegens (the sucrose utilization module) shows a high degree of nutritional complementarity and culturing compatibility with the engineered S. elongatus (the CO2 sequestration module). The combination of both species channels CO2 into various valuable chemicals, enabling carbon‐negative biosynthesis.
Synthesis and characterization of a novel active polymer for enhanced oil recovery
Authors: Chen Qingyuan , Zhang Shusong , Wang Zhouxin , Ye Zhongbin , Lai Nanjun 
Published: February 2023

AbstractA new type of quaternary ammonium surface‐active polymer for enhanced oil‐recovery application was synthesized through the free‐radical polymerization of a functional monomer (DMCA) with acrylic acid (AA) and acrylamide (AM) and denoted as AM/AMPS/DMCA. The optimum polymerization conditions of AM/AMPS/DMCA were explored, and its chemical structure was characterized by Fourier transform infrared spectroscopy, hydrogen nuclear magnetic resonance, and environmental scanning electron microscopy. The molecular weight of AM/AMPS/DMCA was determined by gel‐permeation chromatography. Its thickening ability, oil–water interfacial tension, and emulsifying property were investigated. Results showed that AM/AMPS/DMCA had superior thickening ability and lower interfacial tension than the binary polymer AM/AMPS, as well as good emulsifying properties. AM/AMPS/DMCA also yielded 26.00% oil recovery, higher than the 20.57% of AM/AMPS, as determined using polymer‐flooding tests. The oil‐displacement mechanisms of this surface‐active polymer at pore level were also explored. Analysis of microscopic displacement characteristics through a visual micromodel revealed that AM/AMPS/DMCA solution improved sweep efficiency and reduced residual‐oil saturation due to its bulk viscosity and surface activation. All these findings indicated the excellent potential of AM/AMPS/DMCA in oil displacement.
Effects of dolomite and intumescent flame retardant additions on thermal and combustion behaviors of rigid polyurethane foams
Authors: Aydoğan Bilal , Usta Nazim 
Published: February 2023

AbstractWeak thermal stability and low‐burning resistance of the rigid polyurethane foams are the classic problems in the usage of them. Therefore, it is required to improve these problems of the foams while reducing the cost of production. This study investigated the effects of dolomite (DOL) and intumescent flame retardant (IFR) system on thermal and combustion behaviors of rigid polyurethane foams (RPUFs). For this purpose, DOL (5, 10, and 15 wt%) and DOL/IFR (5/5, 10/5, and 5/10 wt%) combinations were added into RPUFs. Thermogravimetric analyses were performed to investigate the thermal decompositions of the foams and the thermal conductivity measurements were performed to examine the effects of DOL and DOL/IFR additions on the thermal insulation properties of the foams. Cone calorimeter and UL 94 tests were performed to investigate the fire resistances of the foams. The test results showed that up to 15 wt% DOL could be incorporated into the rigid polyurethane foams as filler without any problems in the foam productions, and the thermal and the combustion behaviors of the foams were slightly enhanced. In addition, it was determined that IFR should be used to improve the thermal stability and the fire resistance of the DOL added foams. Among DOL/IFR combinations, 5 wt% DOL and 10 wt% IFR addition satisfied the best performance in terms of the thermal stability and the fire resistance with reducing the smoke, CO, CO2 and NO emissions. In general, the additions of DOL and IFR slightly increased the thermal conductivity coefficients of the foams.
SC‐560 and mofezolac isosteres as new potent COX‐1 selective inhibitors with antiplatelet effect
Authors: Sisa Miroslav , Konečný Lukáš , Temml Veronika , Carazo Alejandro , Mladěnka Přemysl , Landa Přemysl 
Published: February 2023

AbstractSelective cyclooxygenase (COX)‐1 inhibitors can be employed as potential cardioprotective drugs. Moreover, COX‐1 plays a key role in inflammatory processes and its activity is associated with some types of cancer. In this work, we designed and synthesized a set of compounds that structurally mimic the selective COX‐1 inhibitors, SC‐560 and mofezolac, the central cores of which were replaced either with triazole or benzene rings. The advantage of this approach is a relatively simple synthesis in comparison with the syntheses of parent compounds. The newly synthesized compounds exhibited remarkable activity and selectivity toward COX‐1 in the enzymatic in vitro assay. The most potent compound, 10a (IC50 = 3 nM for COX‐1 and 850 nM for COX‐2), was as active as SC‐560 (IC50 = 2.4 nM for COX‐1 and 470 nM for COX‐2) toward COX‐1 and it was even more selective. The in vitro COX‐1 enzymatic activity was further confirmed in the cell‐based whole‐blood antiplatelet assay, where three out of four selected compounds (10a,c,d, and 3b) exerted outstanding IC50 values in the nanomolar range (9–252 nM). Moreover, docking simulations were performed to reveal key interactions within the COX‐1 binding pocket. Furthermore, the toxicity of the selected compounds was tested using the normal human kidney HK‐2 cell line.
Effects of the geometry of reinforcement on physical properties of sodium caseinate/TiO2 nanocomposite films for applications in food packaging
Authors: Hoyos Merlano Nurys Tatiana , Guz Lucas , Borroni Virginia , Candal Roberto Jorge , Herrera María Lidia 
Published: February 2023

AbstractPlastic materials for food packaging are being replaced by biodegradable films based on biopolymers due to the adverse effects they have had on animal life and the environment. In this study, nanocomposite films containing 2.5 wt% sodium caseinate and 2 wt% glycerol were reinforced with 0.1 or 0.2 wt% nano TiO2 prepared in two forms: spheres (P25) and tubes. The effects of nanoreinforcement geometry on mechanical, tensile, barrier, thermogravimetric, and optical properties, and distribution of nanoparticles were described. The interactions among film components were analyzed by Fourier transform infrared spectroscopy (FTIR). Addition of nanotubes significantly increased E' (341 wt%) and E" (395 wt%) moduli, the Young modulus E (660 wt%), the residual mass at 500°C (38 wt%), and color change (6.78) compared to control film. The compositional mapping studies showed that P25 nanoparticles were homogeneously distributed between the surfaces of the film while nanotubes were found on the bottom surface. The changes in position of the FTIR spectra signals as compared to pure protein signals indicated strong matrix/reinforcement interactions. In addition, the changes in intensity in 1100, 1033, and 1638 cm−1 FTIR signals suggested formation of a protein/Tween 20 ester. The geometry of reinforcement was highly relevant regarding physical properties, showing nanotubes as being very successful for enhancing tensile properties.
ITGB3 promotes cisplatin resistance in osteosarcoma tumors
Authors: Li Qian , Chen Guangyou , Jiang Huachai , Dai Haoping , Li Dongdong , Zhu Kai , Zhang Kaiquan , Shen Huarui , Xu Houping , Li Sen 
Published: February 2023

AbstractObjectiveOsteosarcoma is the most malignant and common primary bone tumor with a high rate of recurrence that mainly occurs in children and young adults. Therefore, it is vital to facilitate the development of novel effective therapeutic means and improve the overall prognosis of osteosarcoma patients via a deeper understanding of the mechanisms of chemoresistance in osteosarcoma progression.MethodsIn this research, the relationship between ITGB3 and the clinical characteristics of patients was detected through analysis of publicly available clinical datasets. The expression of ITGB3 was analysis in collected human osteosarcoma tissues. In addition, the potential functions of ITGB3 in the cisplatin resistance of osteosarcoma cells were investigated in vitro and in tumor xenotransplantation. Finally, the molecular mechanism of ITGB3 in the progression and recurrence of osteosarcoma were explored via transcriptome analysis.ResultsITGB3 was identified as a potential regulator of tumorigenicity and cisplatin resistance in relapsed osteosarcoma. Furthermore, the decreased osteosarcoma cell proliferation and migration ability in ITGB3 knockout osteosarcoma cells were related to increased apoptosis and slowing cell cycle progression. In addition, ITGB3 had a positive correlation with cisplatin resistance in cells and tumor xenografts in mice. Accordingly, ITGB3 performed the functions of proliferation and cisplatin resistance in osteosarcoma through the MAPK and VEGF signaling pathways.ConclusionOur results will contribute to a better understanding of the function and mechanism of ITGB3 in osteosarcoma cisplatin resistance and provide a novel therapeutic target to decrease cisplatin resistance and tumor recurrence in osteosarcoma patients.
“In my own comfort zone”: Clients' experiences of relational aspects of online therapy for alcohol problems
Authors: Atkinson Louise 
Published: February 2023

AbstractBackgroundTherapists and counsellors increasingly use online video applications to offer treatment in place of face‐to‐face delivery. In the alcohol treatment sector, this offers a range of potential benefits for treatment providers. However, the impact of working remotely via video on the therapeutic relationship remains unclear and under‐researched.AimsThis study aimed to explore how alcohol treatment clients make sense of the relational aspects of therapy delivered remotely, and to examine how the use of remote therapy might disrupt existing ideas around the therapeutic relationship.MethodologyThis study utilised a qualitative design using thematic analysis, with 15 participant interviews with adult service users from a single treatment provider. All participants had previously undertaken at least four 1‐h online therapy sessions.FindingsThe themes that were identified highlighted the significance of the participants' own homes as the site of therapy, with emphasis on the comfort of the home, and the presence of family members and pets. Participants stressed the importance of viewing the face of the therapist, the establishment of a therapeutic bond and specific therapist qualities. Participants also reflected on issues around denial and avoidance associated with self‐image and identity.DiscussionThere are nuanced and potentially unforeseen consequences of undertaking therapy for alcohol problems via video, relating to the significance of the therapy environment and relationship between client and therapist. This may include issues of shame, denial and avoidance, which are of particular significance for clients experiencing difficulties associated with alcohol.
Personality traits, money attitudes and consumer decision‐making styles as predictors of investment products choice in South Africa
Authors: Ngcamu Lesego Jenny , Quaye Emmanuel Silva , Horvey Sylvester Senyo , Jaravaza Divaries Cosmas 
Published: February 2023

AbstractThis study examines how personality traits and money attitudes influence consumers' decision‐making styles when purchasing investment products in South Africa. A sample of 269 South Africans completed the research questionnaire, which assessed their extraversion, conscientiousness, openness, money power/prestige, money retention/time, money quality, info‐mising, extending, and tax‐free investment purchase decision. Also, confirmatory factor analysis and structural equation modelling approaches were used to analyze the survey data.The results suggest that personality traits and money attitudes significantly impact consumer decision‐making regarding tax‐free investment products. However, the relationships between extraversion and money power/prestige and between info‐mising decision styles and tax‐tree investment purchase decisions were found to be negative. Cluster analysis revealed three distinct segments based on the characteristics of respondents and their drive for investment: strong conscientiousness investors, status‐driven investors, and introverted investors. Marketing professionals and investment firms can use the study findings on consumer traits and money attitudes to improve marketing effectiveness in an organisation. Practically, extensive information processing has a fundamental bearing on investment decision‐making in emerging markets. Extraversion and conscientiousness personality traits and money attitudes must be taken into consideration by investment products marketers and practitioners in marketing practice.
Research on the Performance of Cobalt Oxide Decorated Graphite Felt as Electrode of Iron‐Chromium Flow Battery
Authors: Ren Hai‐lin , Su Yang , Zhao Shuai , Li Cheng‐wei , Wang Xiao‐min , Li Bo‐han , Li Zhen 
Published: February 2023

AbstractIn this paper, cobalt oxide‐modified graphite felt electrodes were prepared by electrodepositing cobalt nitrate on graphite felt and calcined. The surface morphology of graphite felt modified by cobalt oxide was characterized in detail by scanning electron microscope X‐ray diffraction and X‐ray photoelectron spectroscopy. Shape, microstructure, etc. And using the three‐electrode system to conduct cyclic voltammetry, electrochemical impedance spectroscopy, and single‐cell constant current charge and discharge detection on the graphite felt electrodes modified with different concentrations of cobalt oxide, and study its use as an electrode for iron‐chromium redox flow battery performance. The results show that the method of calcination after electrodeposition successfully attaches cobalt oxide to the graphite felt fiber uniformly in granular form, increases a large number of oxygen‐containing functional groups, and has the highest coulombic efficiency for the first charge‐discharge cycle at a current density of 142mAcm−2 It can reach 82 %, and the charging capacity is also increased by 1.59 times compared with the original graphite felt.