bluuebunny/crossref_metadata_2025_split huggingface dataset:
Health literacy and medication adherence in adults from ethnic minority backgrounds with Type 2 Diabetes Mellitus: a systematic review
Authors: Parmar Jinal , El Masri Aymen , MacMillan Freya , McCaffery Kirsten , Arora Amit 
Published: January 2025

Abstract

Background
For people living with Type 2 Diabetes Mellitus (T2DM), achieving optimal health outcomes requires optimal self-management and adherence to medical treatment. While some studies suggest an association between poor medication adherence and lower levels of health literacy, the evidence for this association remains inconclusive. This systematic review aimed to synthesise the evidence on the association between health literacy and medication adherence among adults from ethnic minority backgrounds living with T2DM.

Methods
Medline (Ovid), The Cochrane Library, Embase (Ovid), PsycInfo (EBSCO), and the Cumulative Index to Nursing and Allied Health Literature (CINAHL) (EBSCO) were searched systematically for peer-reviewed literature, published until January 2024. Studies were included in this review if they assessed health literacy and medication adherence among ethnic minority people with T2DM. Two reviewers independently screened and selected the studies, extracted data from the included articles, and assessed the methodological quality of the studies. The methodological quality and bias in designing, conducting, and analysis of each study were evaluated using a standardised JBI critical appraisal tool.

Results
Of the total 6,318 identified studies, seven studies were included in the review. The total participant sample sizes across these studies varied from 53 to 408 participants. All included studies incorporated cross-sectional design for the research, with the majority conducted in the USA. Of the seven unique studies, only one study observed a significant association between health literacy and medication adherence among people from an ethnic minority background.

Conclusions
Evidence on the association between health literacy and medication adherence in ethnic minority adults with T2DM is weak and inconsistent. To understand this association more clearly in ethnic minority populations and to address the disparities in cultural and linguistic considerations, well-designed studies are required.

Trial registration
This review is registered with PROSPERO (CRD42022328346).
Training received, knowledge, and use of Silver Diamine Fluoride among Italian dentists: a nationwide survey
Authors: Salerno Claudia , Conti Giulio , Cirio Silvia , Maspero Cinzia , Senna Andrea , Campus Guglielmo , Cagetti Maria Grazia 
Published: January 2025

Abstract

Objective
To investigate the education, knowledge and behaviour of Italian dentists regarding Silver Diamine Fluoride (SDF).

Methods
A cross-sectional study was conducted from January to December 2022, through an online survey linked to an online continuing medical education (CME) course sent to Italian dentists. A priori power analysis estimated the necessary sample to be 1480 dentists with an anticipated frequency of 50% and a power of 99.99%. The questionnaire included 46 questions on participants ‘ demographic characteristics, training received, clinical knowledge of SDF, and attitudes and behaviours regarding its use. Descriptive statistics, bivariate, and mutlivariable regression analyses were performed to determine the association between the variables.

Results
The response rate was 6.1% with 3876 respondents, evenly distributed geographically. Less than 10% of respondents had received training at undergraduate, postgraduate or masters level. A minority of dentists were familiar with the use of SDF for the treatment of dentine hypersensitivity (19.0%) and for the treatment of caries in children (22.2%) and adults (15.7%). The percentage of dentists who reported SDF use at least once was 20.6%. On mutlivariable analysis (χ2
(11) = 995.9 p-value < 0.01), dentists who used SDF were positively associated with those who cared for patients with special needs, those who received good undergraduate or postgraduate training, and those who knew how to use SDF (p < 0.01). A second mutlivariable analysis (χ2
(11) = 47.9 p-value < 0.01) revealed that younger respondents were associated with good training and knowledge of the use of SDF received during undergraduate studies, while older respondents were associated with good training received on managing hypersensitivity and caries in adults (p < 0.01).

Conclusions
Overall, Italian dentists ‘ education, knowledge, and use of SDF were relatively poor. The majority of the sample ‘s responses were not consistent with scientific evidence. The use of SDF among Italian dentists is still far from being a reality. In Italy, it is necessary to increase training on SDF, primarily through the university, to hopefully increase its use, especially in non-invasive caries treatment.
Improving access to services in neuro-developmental disability: proceedings of a national meeting to advance community capacity
Authors: Nicholas David B. , Lach Lucyna M. , Sutherland Samantha B. , Maxwell Joanne , McFarland Stephanie , Miller Anton R. , Clancy Angela , Scorah Julie 
Published: January 2025

Abstract
As part of a participatory project to advance navigational service delivery systems for children with neurodevelopmental disability (NDD) and their families, this paper addresses proceedings from a capacity-building conference in Vancouver, Canada. A total of 29 invited key stakeholders attended the meeting with the following aims: knowledge sharing amongst provincial/territorial regions advancing NDD navigation capacity; sustainable action-oriented knowledge exchange; and operationalizing next steps to build navigation resources across Canadian regions. Regional representation included multiple and inter-sectoral partners (e.g., not-for-profit organizations, government, education, health, researchers, etc.) strategically invited to address mutually-agreed upon regional challenges, where ideas for envisioning, planning and success could be developed for ultimate operationalization in three Canadian provinces and one territory based on need for building navigational service delivery systems in NDD.
Advancements in navigational service delivery were shared by site leads in the four represented regions of the initiative: Alberta, British Columbia, Quebec, and Yukon. Each regional lead conveyed targeted accomplishments, priorities and issues in moving navigation forward. Identified successes comprised the development of trusting partnerships across agencies and sectors, innovation and connection among service/navigation organizations and leaders, and training advances. Struggles included insufficient regional clarity on guiding principles for navigation services, a lack of resources relative to family need for services, and insufficient infrastructural supports in regions. Based on key learnings within and across regional groups, plans for regional development were strategized and shared.
Insecticide resistant Anopheles from Ethiopia but not Burkina Faso show a microbiota composition shift upon insecticide exposure
Authors: Worku Netsanet , Sanou Antoine , Hartke Juliane , Morris Marion , Cissé Fatoumata , Ouédraogo Salimata , Tapsoba Madou , Vallon Nicola , Akilu Tewodros Debebe , Worku Ligabaw , Guelbeogo Moussa Wamdaogo , Ingham Victoria A. 
Published: January 2025

Abstract

Background
Malaria remains a key contributor to mortality and morbidity across Africa, with the highest burden in children under 5. Insecticide-based vector control tools, which target the adult Anopheles mosquitoes, are the most efficacious tool in disease prevention. Due to the widespread use of these interventions, insecticide resistance to the most used classes of insecticides is now pervasive across Africa. Understanding the underlying mechanisms contributing to this phenotype is necessary to both track the spread of resistance and to design new tools to overcome it.

Methods
Here, we compare the microbiota composition of insecticide-resistant populations of Anopheles gambiae, An. coluzzii and An. arabiensis from Burkina Faso, and in the latter case additionally from Ethiopia, to insecticide-susceptible populations.

Results
We show that the microbiota composition between insecticide-resistant and -susceptible populations does not differ in Burkina Faso. This result is supported by data from laboratory colonies originating in Burkina Faso across two countries. In contrast, An. arabiensis from Ethiopia demonstrates clear differences in microbiota composition in those dying from and those surviving insecticide exposure. To further understand resistance in this An. arabiensis population, we performed RNAseq and saw differential expression of detoxification genes associated with insecticide resistance and changes in respiration, metabolism and synapse-related ion channels.

Conclusions
Our results indicate that, in addition to changes in the transcriptome, microbiota can contribute to insecticide resistance in certain settings.

Graphical Abstract
An indirect ELISA for the detection of antibodies against Dirofilaria spp. in cats
Authors: Perles Lívia , Carbonara Mariaelisa , Mendoza-Roldan Jairo Alfonso , Venco Luigi , Gabrielli Simona , Otranto Domenico 
Published: January 2025

Abstract

Background

Dirofilaria immitis and D. repens are mosquito-borne filaroids that primarily infect dogs but also cats. Diagnosing feline dirofilariosis is challenging because of the low parasitic burdens and transient or absent microfilaremia. To improve detection of antibodies against Dirofilaria spp. in cats, an indirect enzyme-linked immunosorbent assay (ELISA) using somatic antigens of D. immitis was standardized.

Methods
Serum samples from cats positive for D. immitis, D. repens, bronchopulmonary metastrongylids and gastrointestinal helminths as well as negative sera were tested to evaluate the sensitivity (Se) and specificity (Sp). Three different antigen concentrations (2, 3 and 4 μg/ml) and two concentrations of horseradish peroxidase (HRP) IgG anti-cat conjugate (1:10,000 and 1:20,000) were used to screen the optimal titration of the test. Once the best conditions were established, Se and Sp were assessed by testing 151 serum samples positive for D. immitis, D. repens and other parasites (i.e. feline lungworms, gastrointestinal helminths) or negative.

Results
The optimized ELISA showed 89% Se and 98% Sp in detecting D. immitis infections, presenting a cross-reactivity with D. repens. A cut-off point of 1.150 was established to classify positive and negative samples.

Conclusions
The developed ELISA may improve the detection of antibodies against Dirofilaria spp. in cats, also in epidemiological contexts characterized by multiple helminth infections. Future efforts will focus on reducing the cross-reactivity with D. repens, therefore increasing ELISA Sp.

Graphical Abstract
Recursive seed amplification detects distinct α-synuclein strains in cerebrospinal fluid of patients with Parkinson’s disease
Authors: Bräuer Stefan , Schniewind Iñaki , Dinter Elisabeth , Falkenburger Björn H. 
Published: January 2025

Abstract
Parkinson’s disease (PD) is a heterogeneous neurodegenerative disorder with a wide range of clinical phenotypes. Pathologically, it is characterized by neuronal inclusions containing misfolded, fibrillar alpha-synuclein (aSyn). Prion-like properties of aSyn contribute to the spread of aSyn pathology throughout the nervous system as the disease progresses. Utilizing these properties, seed amplification assays (SAA) enable the detection of aSyn pathology in living patients. We hypothesized that structurally distinct aSyn aggregates, or strains, may underlie the clinical heterogeneity of PD. To test this hypothesis, we recursively amplified aSyn fibrils from the cerebrospinal fluid (CSF) of 54 patients (34 people with PD and 20 controls). These fibrils were then characterized regarding SAA kinetic properties and detergent resistance. In addition, cultured cells were transfected with SAA products, and the extent of seeded aSyn pathology was quantified by staining for phosphorylated aSyn followed by automated high-throughput microscopy and image analysis. We found that fibrils, amplified from CSF by recursive SAA, exhibit two types of distinct biophysical properties and have different seeding capacities in cells. These properties are associated with clinical parameters and may therefore help explain the clinical heterogeneity in PD. Measuring aSyn strains may be relevant for prognosis and for therapies targeting aSyn pathology.
Intravitreal dexamethasone implant (Ozurdex®) findings over time: ultrasound and ultra-widefield fundus photography
Authors: Pellegrini Gabriela Assumpção Brito Pereira , Bordon Arnaldo Furman , Allemann Norma 
Published: January 2025

Abstract

Background
Ozurdex® (Allergan®, AbbVie Company, North Chicago, Illinois, EUA), is composed of 0.7 mg of dexamethasone, fused in a solid biodegradable PLGA polymer, whose degradation occurs naturally in the vitreous cavity, usually in six months after its application.

Methods
In this study, we included patients aged ≥ 18 years with one or two eyes who had an indication for Ozurdex® implants. Eyes submitted to Ozurdex® application were evaluated in the first hour after the injection via transpalpebral contact B-scan ocular ultrasonography (Aviso® or Compact Touch®, Quantel®) and non-mydriatic ultra-widefield fundus photography (California®, Optos®) performed sequentially. The exams were executed using similar parameters and techniques, by the same ophthalmologist, after every 45 days, until the end of 180 days. The programed visits were the initial (tagged D0) and sequential (D45, D90, D135, and D180) visits, with a possible variance of seven days, before or after. The ultrasonographic Ozurdex® findings evaluated were: non-quantitative: structure, height, reflectivity, artifact production, location, and movement; and quantitative: length and thickness. Ultra-widefield fundus photography parameters were: Ozurdex® visualization, location, and structure.

Results
The B-scan showed the implant initially, at the D0 visit, as a well-delimited and homogeneously highly reflective linear and continuous structure. On D45, Ozurdex® implants presented with low internal reflectivity and irregularity in the limits. On D90, D135, and D180, reductions in the length and thickness progressively lessened, leading to the final appearance of a small highly reflective clust. Over time, all the implants presented reductions in length and thickness. The mean length at D0 was 7.42 ± 0.39 mm and at the final visit (D180) it was 1.50 ± 0.47 mm. The mean thickness at D0 was 0.77 ± 0.13 mm and at the final visit (D180) it was 0.44 ± 0.18 mm.

Conclusions
Considering implant dimensions, the change in length over time was more evident than the change in thickness. In all the cases where visualization was possible, positive correlations with B-scan findings were found despite changes in patient position. These alterations evidenced in the Ozurdex® implant over time may be related to the degradation of the glucose polymer structure.
Enhancing peer assessment with artificial intelligence
Authors: Topping Keith J. , Gehringer Ed , Khosravi Hassan , Gudipati Srilekha , Jadhav Kaushik , Susarla Surya 
Published: January 2025

Abstract
This paper surveys research and practice on enhancing peer assessment with artificial intelligence. Its objectives are to give the structure of the theoretical framework underpinning the study, synopsize a scoping review of the literature that illustrates this structure, and provide a case study which further illustrates this structure. The theoretical framework has six areas: (i) Assigning Peer Assessors, (ii) Enhancing Individual Reviews, (iii) Deriving Peer Grades/Feedback, (iv) Analyzing Student Feedback, (v) Facilitating Instructor Oversight and (vi) Peer Assessment Systems. The vast majority of the 79 papers in the review found that artificial intelligence improved peer assessment. However, the focus of many papers was on diversity in grades and feedback, fuzzy logic and the analysis of feedback with a view to equalizing its quality. Relatively few papers focused on automated assignment, automated assessment, calibration, teamwork effectiveness and automated feedback and these merit further research. This picture suggests AI is making inroads into peer assessment, but there is still a considerable way to go, particularly in the under-researched areas. The paper incorporates a case study of the RIPPLE peer-assessment tool, which harnesses student wisdom, insights from the learning sciences and AI to enable time-constrained educators to immerse their students in deep and personalized learning experiences that effectively prepare them to serve as assessors. Once trained, they use a comprehensive rubric to vet learning resources submitted by other students. They thereby create pools of high-quality learning resources which can be used to recommend personalized content to students. RIPPLE engages students in a trio of intertwined activities: creation, review and personalized practice, generating many resource types. AI-driven real-time feedback is given but students are counseled to assess whether it is accurate. Affordances and challenges for researchers and practitioners were identified.
The potential of aloe vera gel utilization for skin wound healing in rats based on GC–MS and HPLC chemical profile
Authors: Arafa Nadia Mohamed Said , Hummadi Huda Mohammad Ahmad , Badr Gehan Moustafa 
Published: January 2025

Abstract

Background
Wound healing is a restoration process of tissue integrity and function targeting reducing the healing time and complications with priority of available, acceptable and affordable medication. The study aimed to evaluate wound healing of aloe vera gel as raw or ethanol extract on a dorsal full thickness circular wound in Wistar rats. Rats subjected to the excision surgery were grouped into: control (+ ve), without treatment. and Kenacomb, aloe raw gel and aloe ethanol extract applied groups for 3, 7, 14 and 21 days for treatment evaluation. The study chromatographically quantified anthraquinones and identified the raw gel and extract’ compounds. The evaluation was through the assessment of the wound contraction and complete blood count, serum interleukin-4 and skin tissue proline, hydroxyproline, glycine, malondialdehyde, nitric oxide contents and skin histopathology investigation at tested intervals.

Results
Raw gel and extract contained in μg/ml, aloin A (9.23 and 17.22), aloin B (8.87 and 10.31) and emodin (11.66 and 12.66), respectively. The predominates identified percentage in raw gel were coumarins (34.93), fatty acids (28.45), phytosterols (7.77) and tocopherols (8.44) and in gel extract were phytosterols (49.39), fatty acids (29.16) and tocopherols (3.70). Results after 21 days were recorded in + ve control 80.50% wound contraction and showed significantly decreased values of IL-4, lymphocytes, Hb, RBCs and skin glycine, proline, hydroxyproline and NO. Neutrophils, monocytes, platelets and MDA were significantly increased. Histologically revealed epidermal acanthosis, inflammatory infiltration, fibrosis with hair follicles and sebaceous glands loss and dermal hemorrhage. Aloe raw gel revealed incomplete healing (91.79%) and failed to normalize IL-4, lymphocytes, neutrophils and the skin glycine and NO contents. Skin showed moderate epidermal acanthosis, and dermis had fibrosis, hemorrhage and loss of sebaceous glands and hair follicles. The extract group acquired 100% healing, normalized tested parameters and showed skin tissue thinning epidermis and intact dermal tissue with sebaceous glands and hair follicles.

Conclusion
Results revealed aloe gel ethanol extract advantage over raw gel for wound healing which may be related to chemical constituents’ variation interpreted in interest to the extract as an efficient therapeutic, cost-effective, available wound healing material.
Post-harvest conservation practices, related insect pests of stored pearl millet (Pennisetum glaucum (L) R. Br.), and their management in northern Benin
Authors: Alagbe Tayé Obédatou , Loko Yeyinou Laura Estelle , Djègbè Innocent , Gandjala Julien , Gavoedo Dieudonné , Tamò Manuele 
Published: January 2025

Abstract

Background
Pearl millet (Pennisetum glaucum (L.) R. Br.) production has decreased over the years due to several constraints, including insect pest attacks, which contribute to its status as neglected and underutilized species in Benin. In order to develop an integrated pest management strategy, we documented farmers’ post-harvest conservation practices, perceptions, and management of storage insect pests. Four hundred millet producers were surveyed using a semi-structured questionnaire in 76 villages in northern Benin. The entomofauna associated with stored pearl millet was identified by extracting samples from farmers’ storage structures and incubating them for a month in the laboratory.

Results
Our results showed that farmers perceived insect pests as the most important constraint to pearl millet storage. Vernacular taxonomy and local nomenclature of insect pests of stored pearl millet varied among sociolinguistic groups. Four species of insects were associated with stored millet with the weevils Sitophilus oryzae L. and Sitophilus zeamais L. as the most important ones. Three storage structures (attic, bedroom, and store) and a storage tool (polypropylene bags) were inventoried. Synthetic chemical insecticides were the most commonly used method for protecting stored millet. Also, farmers employed four plants that repel and kill insects to safeguard stored pearl millet. A differential sensitivity of pearl millet varieties to storage insect attacks was reported with four potential resistant varieties. Some factors that influence the use of a pest management method were determined.

Conclusions
The development of an integrated pest management needs to test the sensitivity of resistant varieties and the bioactivity of recorded insecticidal plants. The farmers’ perception suggests that the Souhoun n’nin gberenou landrace and the usage of bark of A. senegalensis and leaves of A. indica are the best ways to preserve millet for a long time. Raising awareness among pearl millet producers on good storage practices and the biological management of storage insect pests were recommended. Factors that influence the use of pest management methods must be integrated into the development of national strategies.
Facebook addiction among medical students: prevalence and consequences
Authors: Mohamed Eman Fouad , Mohamed Amany Elshabrawy , Youssef Amira Mohamed , Sehlo Mohammad Gamal , Soliman Eman Seif Alnasr , Ibrahim Abdallah Saad 
Published: January 2025

Abstract

Background
Social media addiction, mainly Facebook, is a common emerging behavior, particularly among teens and young adults. The current study’s primary goal is to determine the prevalence of Facebook addiction and assess its influence on academic performance and mental health among medical students.

Methods
Six-hundred twenty-seven students from the Faculty of Medicine, Zagazig University, at Egypt were included at this cross-sectional study. A semi-structured questionnaire designed by authors was used to collect sociodemographic data and data about academic performance and sleep. Facebook addiction was investigated using a scale which is Bergen Facebook Addiction Scale (BFAS). The Depression Anxiety Stress Scale-21 (DASS-21) was utilized to screen for anxiety, depression, and stress.

Results
Between medical students, 16.6% had score above 24 and considered to have Facebook addiction. Facebook addiction had a substantial association with uncontrollable Internet use, affection of study hours, and decrease in academic scores. There is statistically considerable relation between Facebook addiction and anxiety, depression, and stress.

Conclusions
Facebook addiction is common among medical students and had a negatory impact on both their academic achievement and mental health.