bluuebunny/crossref_metadata_2025_split huggingface dataset:
Circulating Inflammatory Cytokines and Female Reproductive Diseases: A Mendelian Randomization Analysis
Authors: Lin Yiting , Wang Guiquan , Li Yan , Yang Haiyan , Zhao Yue , Liu Jun , Mu Liangshan 
Published: June 2023

AbstractContextExtensive studies have provided considerable evidence suggesting the role of inflammation in the development of female reproductive diseases. However, causality has not been established.ObjectiveTo explore whether genetically determined circulating levels of cytokines are causally associated with female reproductive diseases and discover potential novel drug targets for these diseases.MethodsInstrumental variables (IVs) for 47 circulating cytokines were obtained from a genome-wide association study (GWAS) meta-analysis of 31 112 European individuals. Protein quantitative trait loci and expression quantitative trait loci close to genes served as our IVs. Summary data of 9 female reproductive diseases were mainly derived from GWAS meta-analysis of the UK biobank and FinnGen. We elevated the association using the Wald ratio or inverse variance–weighted Mendelian randomization (MR) with subsequent assessments for MR assumptions in several sensitivity and colocalization analyses. We consider a false discovery rate &lt;0.05 as statistical significance in MR analyses. Replication studies were conducted for further validation, and phenome-wide association studies were designed to explore potential side effects.ResultsOur results indicated that high levels of macrophage colony-stimulating factor (MCSF), growth-regulated oncogene-alpha (GROα), and soluble intercellular adhesion molecule-1 were associated with increased risks of endometriosis, female infertility, and pre-eclampsia, respectively. High platelet-derived growth factor-BB (PDGF-BB) levels that reduced the risk of ovarian aging were also supported. Replication analysis supported the relationship between GROα and female infertility, and between MCSF and endometriosis.ConclusionWe identified 4 correlated pairs that implied potential protein drug targets. Notably, we preferred highlighting the value of PDGF-BB as a drug target for ovarian aging, and MCSF as a drug target for endometriosis.
“She Whistles Freely Shunning Companions”: The Embedded and Transcendent Selves of Poet-Painter Wang Liang in the Eighteenth Century
Authors: Theiss Janet 
Published: June 2023

Abstract
This article examines the unusual life of the poet and painter Wang Liang (ca. 1720–1790). Granddaughter of a prominent Jiaxing bibliophile and collector, she lost her father in infancy and married into a respected Huzhou family of officials only to witness their demise amidst a very public sex and corruption scandal in 1740, which also implicated her own wealthy merchant family. In the wake of this disaster, she and her husband severed their family ties and lived out their years in genteel poverty, childless. Surviving her husband by over twenty-five years, she fashioned an independent life and a self-image, echoed by observers, of Daoist detachment from the proverbial dust of the world while cultivating relationships with prominent male mentors and female artists across Jiangnan. As poet, painter, and player of the zither and the game of Go, Wang Liang at times articulated a vision of explicitly ungendered artistic perfection resembling aspects of the androgynous ideal associated with the culture of the Ming-Qing transition. Yet she was also poignantly aware that she was still embedded in relationships that pulled her back into family obligation, gendered hierarchy, and social exchange. I delve into her extant poetry and commentary about her to present her life and art as a contrapuntal play between embedded and transcendent modes of identity and expression.
From Convention to Subversion: Case Studies on the Female Gaze in Premodern China
Authors: Fong Grace S. 
Published: June 2023

Abstract
This article engages the ekphrastic mode—the literary representation of visual representation—to examine the female gaze instantiated in women's poetry on paintings of beautiful women in the Ming and Qing periods. Through four case studies, it shows how women poets and painters participated in the visual culture of late imperial China and negotiated gendered difference in their aesthetic vision and artistic production.
Variable body and tissue weight reporting in preclinical cachexia literature may alter study outcomes and interpretation
Authors: Beaudry Anna G. , Law Michelle L. 
Published: June 2023

ABSTRACT
Cancer cachexia is a multifactorial syndrome of body weight loss, muscle wasting and progressive functional decline, affecting many advanced cancer patients and leading to worsened clinical outcomes. Despite inherent limitations of many preclinical cachexia models, including large tumor burden, rapid tumor growth and young age of animals, these animal models are widely used and imperative for the study of cachexia mechanisms and experimental therapeutics. However, there are currently no guidelines for the reporting and representation of data in preclinical cachexia literature. We examined the current state of data reporting in publications using the colon-26 adenocarcinoma (C26) model of cachexia and compared statistical differences in reporting mechanisms using animals from our laboratory. We show that data reporting and representation in C26 preclinical cachexia literature are diverse, making comparison of study outcomes difficult. Further, different expression of body and tissue weights in our animals led to differential statistical significance, which could significantly alter data interpretation. This study highlights a need for consistent data reporting in preclinical cancer cachexia literature to effectively compare outcomes between studies and increase translatability to the human condition.
Effect of intraoperative PEEP with recruitment maneuvers on the occurrence of postoperative pulmonary complications during general anesthesia––protocol for Bayesian analysis of three randomized clinical trials of intraoperative ventilation
Authors: Mazzinari Guido , Zampieri Fernando G. , Ball Lorenzo , Campos Niklas S. , Bluth Thomas , Hemmes Sabrine N.T. , Ferrando Carlos , Librero Julian , Soro Marina , Pelosi Paolo , Gama de Abreu Marcelo , Schultz Marcus J. , Serpa Neto Ary ,   PROVHILO investigators,   iPROVE investigators,   PROBESE investigators,   PROVE network investigators
Published: June 2023

Background: Using the frequentist approach, a recent meta–analysis of three randomized clinical trials in patients undergoing intraoperative ventilation during general anesthesia for major surgery failed to show the benefit of ventilation that uses high positive end–expiratory pressure with recruitment maneuvers when compared to ventilation that uses low positive end–expiratory pressure without recruitment maneuvers. Methods: We designed a protocol for a Bayesian analysis using the pooled dataset. The multilevel Bayesian logistic model will use the individual patient data. Prior distributions will be prespecified to represent a varying level of skepticism for the effect estimate. The primary endpoint will be a composite of postoperative pulmonary complications (PPC) within the first seven postoperative days, which reflects the primary endpoint of the original studies. We preset a range of practical equivalence to assess the futility of the intervention with an interval of odds ratio (OR) between 0.9 and 1.1 and assess how much of the 95% of highest density interval (HDI) falls between the region of practical equivalence. Ethics and dissemination: The used data derive from approved studies that were published in recent years. The findings of this current analysis will be reported in a new manuscript, drafted by the writing committee on behalf of the three research groups. All investigators listed in the original trials will serve as collaborative authors.
Clinical equivalence of Trusynth fast® and Vicryl rapide® polyglactin 910 fast absorbing sutures on maternal morbidity experienced by women following episiotomy repair: a single-blind, randomized study
Authors: Hemalatha Devi Dongabanti , Bolanthakodi Chethana , D’Cunha Prema , Bheema Bai Mudiki , Kumar Moharana Ashok , TS Deepak 
Published: June 2023

Background: Episiotomy procedure enlarges the vaginal outlet to facilitate childbirth. Polyglactin 910 fast-absorbing sutures are widely used for the repair of episiotomy because of their rapid absorption and less inflammatory response. This study was designed for subjective assessment of perineal pain post-episiotomy repair, with Trusynth Fast® and Vicryl Rapide® polyglactin 910 fast-absorbing sutures. Method: This was a single-blind, randomized, prospective study conducted between January 7, 2021 and July 14, 2021 across two centers in India. Primiparous or multiparous women (18—40 years), who required episiotomy during vaginal delivery were included, and either Trusynth Fast® (n=47) or Vicryl Rapide® (n=49) suture was used for their episiotomy repair. The primary endpoint, perineal pain was assessed with visual analogue scale at all follow-up visits. The secondary endpoints, quantity of local anesthesia, number of sutures used, time to repair episiotomy, intraoperative suture handling, analgesics used, early and late wound complications, wound re-suturing, time to complete healing, presence of residual sutures, return to sexual activity, dyspareunia, and adverse events were also recorded. Results: The study showed no significant difference in perineal pain between the two groups at any visit. A statistically significant difference (p<0.05) in total score of episiotomy healing scale on day 2 (0.13±0.34 versus 0.35±0.56) and swelling on day 2 (8.51 versusversus 28.57%) was noted between Trusynth Fast® and Vicryl Rapide® group. Non-significant difference was observed between the groups regarding anesthesia, number of sutures, time to repair episiotomy, intraoperative suture handling, analgesics, puerperal fever, wound infection, dehiscence, hematoma, urinary incontinence, re-suturing, time to complete healing, return to sexual activity and dyspareunia. Conclusion: Trusynth Fast® suture is clinically equivalent to Vicryl Rapide® suture and can be used for episiotomy repair with minimal risk of perineal pain and wound complications. Clinical Trials Registry of India Registration: CTRI/2020/12/029925; Registered on December 18, 2020
Current trends, barriers, and facilitators of use of core outcome sets in Cochrane systematic reviews: Protocol
Authors: Saldanha Ian , Hughes Karen , Dodd Susanna , Lasserson Toby , Kirkham Jamie , Lucas Samuel , Williamson Paula 
Published: June 2023

Background: Core outcome sets (COS) represent agreed-upon minimum outcomes that should be reported in all studies in a given topic area. Cochrane reviews are considered among the most rigorously conducted systematic reviews (SRs). In 2019, seven of the first 100 published Cochrane SRs (7%) cited a COS in relation to choosing outcomes. A relevant COS existed but was not mentioned (or cited) for 27 of the remaining 93 SRs (29%). Among Cochrane Review Group editors surveyed in 2019, 86% felt that COS should definitely/possibly be used in Cochrane SRs. As of September 2019, the Cochrane Handbook recommends that SR teams consult resources that host relevant COS when choosing outcomes for the SR. Objectives: (1) Examine the extent to which authors are currently considering COS to inform outcome choice in Cochrane protocols and completed SRs. (2) Understand author barriers and facilitators of using COS in Cochrane protocols and completed SRs. Methods: We will examine the extent to which all Cochrane SRs published in the last 3 months of 2022 and all Cochrane protocols published in 2022: (a) cited a COS, (b) searched for COS, and (c) reported outcome inconsistency among included studies and/or noted the need for COS. One investigator will extract information from SRs and protocols; a second extractor will verify all information, discussing discrepancies to achieve consensus. Using Jisc Online Surveys®, we will conduct an online anonymous survey of authors of all the included completed SRs and protocols to assess author awareness of COS and identify barriers and facilitators of using COS to inform outcome choice. Discussion: This study will provide key information regarding uptake of COS by Cochrane SR authors and the barriers and facilitators that they experience. Our findings will inform approaches to increasing awareness and uptake of COS in future SRs, both with and beyond Cochrane.
Comparative study between therapeutic effects of microneedling versus CO2 laser in acne scars
Authors: Gupta Kunal , Maheshwari Pravin , Madke Bhushan 
Published: June 2023

Objectives: To study the clinical aspect of acne scars while grading them on the basis of severity as well as to study and compare the therapeutic effects of CO2 laser and microneedling in their management. Methods: This study used prospective comparison as its method of study. Over the course of two years, from June 2021 to June 2023, 100 patients above 18 years of age having post-acne atrophic scars will be enrolled. Patients will be split into two groups and each group will be selected for fractional CO2 laser (non-ablative) and microneedling respectively. Four treatments will be administered to each group of patients with a four-week gap between each session. All clinical findings will be recorded for data analysis and comparision. “Goodman and Baron’s Qualitative and Quantitative grading system for scars” will be used after each session in order to compare the therapeutic effects for each group. Results: At the end of each session, acne scar grading will be done in each group and data will be compiled to assess and compare the therapeutic effects between CO2 laser and microneedling. Conclusions: The findings of the protocol research will be used to form the conclusions. Trial Registration: Submitted for registration to Clinical Trial Registry of India (CTRI).
Countercyclical Risks, Consumption, and Portfolio Choice: Theory and Evidence
Authors: Shen Jialu 
Published: June 2023

Using a quantitative, calibrated life-cycle model, I show that countercyclical earnings risk affects individual consumption growth, reduces the share of wealth in stocks, and affects savings behavior. Using the Panel Study of Income Dynamics survey, I construct an empirical measure of countercyclical earnings risk and find evidence consistent with the model’s predictions. Specifically, larger downside earnings risk decreases consumption growth, increases left skewness in consumption growth, and reduces the share of wealth in stocks. Furthermore, the consumption effects are substantially more significant for stockholders than for nonstockholders, which arises through heterogeneity in the elasticity of intertemporal substitution. This paper was accepted by Tomasz Piskorski, finance. Supplemental Material: The data and online appendix are available at https://doi.org/10.1287/mnsc.2023.4837 .
The ORthopaedic Trauma Hospital Outcomes - Patient Operative Delays (ORTHOPOD) study
Authors: Baldock Thomas E. , Walshaw Tom , Walker Reece , Wei Nicholas , Scott Sharon , Trompeter Alex J. , Eardley William G. P. 
Published: June 2023

AimsThis is a multicentre, prospective assessment of a proportion of the overall orthopaedic trauma caseload of the UK. It investigates theatre capacity, cancellations, and time to surgery in a group of hospitals that is representative of the wider population. It identifies barriers to effective practice and will inform system improvements.MethodsData capture was by collaborative approach. Patients undergoing procedures from 22 August 2022 and operated on before 31 October 2022 were included. Arm one captured weekly caseload and theatre capacity. Arm two concerned patient and injury demographics, and time to surgery for specific injury groups.ResultsData was available from 90 hospitals across 86 data access groups (70 in England, two in Wales, ten in Scotland, and four in Northern Ireland). After exclusions, 709 weeks' of data on theatre capacity and 23,138 operations were analyzed. The average number of cases per operating session was 1.73. Only 5.8% of all theatre sessions were dedicated day surgery sessions, despite 29% of general trauma patients being eligible for such pathways. In addition, 12.3% of patients experienced at least one cancellation. Delays to surgery were longest in Northern Ireland and shortest in England and Scotland. There was marked variance across all fracture types. Open fractures and fragility hip fractures, influenced by guidelines and performance renumeration, had short waits, and varied least. In all, nine hospitals had 40 or more patients waiting for surgery every week, while seven had less than five.ConclusionThere is great variability in operative demand and list provision seen in this study of 90 UK hospitals. There is marked variation in nearly all injuries apart from those associated with performance monitoring. There is no evidence of local network level coordination of care for orthopaedic trauma patients. Day case operating and pathways of care are underused and are an important area for service improvement.Cite this article: Bone Jt Open 2023;4(6):463–471.
Round-trip multi-band quantum access network
Authors: Xu Yuehan , Wang Tao , Zhao Huanxi , Huang Peng , Zeng Guihua 
Published: June 2023

The quantum network makes use of quantum states to transmit data, which will revolutionize classical communication and allow for some breakthrough applications. Quantum key distribution (QKD) is one prominent application of quantum networks, and can protect data transmission through quantum mechanics. In this work, we propose an expandable and cost-effective quantum access network, in which the round-trip structure makes quantum states travel in a circle to carry information, and the multi-band technique is proposed to support multi-user access. Based on the round-trip multi-band quantum access network, we realize multi-user secure key sharing through the continuous-variable QKD (CV-QKD) protocol. Due to the encoding characteristics of CV-QKD, the quadrature components in different frequency bands can be used to transmit key information for different users. The feasibility of this scheme is confirmed by comprehensive noise analysis, and is verified by a proof-of-principle experiment. The results show that each user can achieve excess noise suppression and 600 bit/s level secure key generation under 30 km standard fiber transmission. Such networks have the ability of multi-user access theoretically and could be expanded by plugging in simple modules. Therefore, it paves the way for near-term large-scale quantum secure networks.
Healthcare costs and outcomes associated with laboratory-confirmed Lyme disease in Ontario, Canada: A population-based cohort study
Authors: Mac Stephen , Evans Gerald , Pullenayegum Eleanor , Patel Samir N. , Sander Beate 
Published: June 2023

Background
The objective of this study was to estimate the economic burden attributable to laboratory-confirmed Lyme disease (LD) in Ontario, Canada and assess health outcomes associated with LD.

Method
We conducted a cohort study using laboratory-confirmed LD cases accrued between 2006 and 2018. The exposed cohort was matched 1:3 to the unexposed cohort using a combination of hard and propensity score matching. We used phase-of-care costing methods to calculate attributable costs for four phases of illness: pre-diagnosis, acute care, post-acute care, and continuing care in 2018 Canadian dollars. We used ICD-10-CA and OHIP billing codes to identify emergency department visits, physician billings and hospitalizations related to LD sequelae to assess health outcomes.

Results
A total of 2,808 cases were identified with a mean age of 46.5 (20.7) years and 44% female. Within 30-days, 404 (14.3%) cases required an ED visit and 63 (2.4%) cases required hospitalization. The mean (95% CI) total costs for LD cases in pre-diagnosis, acute, and post-acute care phases were $209 ($181, 238), $1,084 ($956, $1,212), and $1,714 ($1,499, $1,927), respectively. The highest mean attributable 10-day cost was $275 ($231, $319) during acute care. At 1-year post-infection, LD increased the relative risk of nerve palsies by 62 (20, 197), and polyneuropathy by 24 (3.0, 190). LD resulted in 16 Lyme meningitis events vs. 0 events in the unexposed.

Conclusion
Individuals with laboratory-confirmed LD have increased healthcare resource use pre-diagnosis and up to six months post-diagnosis, and were more likely to seek healthcare services related to LD sequelae.
Feasibility and acceptability of an mHealth, home-based exercise intervention in colorectal cancer survivors: A pilot randomized controlled trial
Authors: Moraitis Ann Marie , Rose Nathan B. , Johnson Austin F. , Dunston Emily R. , Garrido-Laguna Ignacio , Hobson Paula , Barber Kristin , Basen-Engquist Karen , Coletta Adriana M. 
Published: June 2023

Objective
To determine the feasibility and acceptability of an mHealth, home-based exercise intervention among stage II-III colorectal cancer (CRC) survivors within 5-years post-resection and adjuvant therapy.

Methods
This pilot randomized controlled trial of a 12-week mHealth, home-based exercise intervention, randomly assigned CRC survivors to a high-intensity interval training (HIIT) or moderate-intensity continuous exercise (MICE) prescription. The following assessments were carried out at baseline and end-of-study (EOS): handgrip strength, short physical performance battery (SPPB), PROMIS physical function, neuropathy total symptom score-6 (NTSS-6), Utah early neuropathy scale (UENS), cardiopulmonary exercise testing, anthropometrics, and body composition via BOD POD, modified Godin leisure-time activity questionnaire. Feasibility, as defined by number of completed prescribed workouts and rate of adherence to individualized heart rate (HR) training zones, was evaluated at EOS. Acceptability was assessed by open-ended surveys at EOS. Descriptive statistics were generated for participant characteristics and assessment data.

Results
Seven participants were included in this pilot study (MICE: n = 5, HIIT: n = 2). Median age was 39 years (1st quartile: 36, 3rd quartile: 50). BMI was 27.4 kg/m2 (1st quartile: 24.5, 3rd quartile: 29.7). Most participants had stage III CRC (71%, n = 5). We observed an 88.6% workout completion rate, 100% retention rate, no adverse events, and qualitative data indicating improved quality of life and positive feedback related to ease of use, accountability, motivation, and autonomy. Mean adherence to HR training zones was 95.7% in MICE, and 28.9% for the high-intensity intervals and 51.0% for the active recovery intervals in HIIT; qualitative results revealed that participants wanted to do more/work-out harder.

Conclusion
An mHealth, home-based delivered exercise intervention, including a HIIT prescription, among stage II-III CRC survivors’ post-resection and adjuvant therapy was tolerable and showed trends towards acceptability.