bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of SGLT-2 inhibitor (remogliflozin) plus DPP4 inhibitor (vildagliptin) on diabetic nephropathy in patients with type 2 diabetes mellitus comparison with combination of metformin and sulphonylureas
Authors: Gupta Vishal Kumar , Pannu Deepak , Singh Mahendra Pal , Kumar Lalit 
Published: May 2023

Background: Diabetes is leading cause of renal failure in entire world. Approximately 20-40 percent of patients with diabetes develop diabetic nephropathy. Newer drugs like SGLT-2 inhibitors and DPP-4 inhibitors are valuable option for Diabetic Nephropathy. Remogliflozin etabonate (RE) is the latest addition to the SGLT2 inhibitor class of drugs that have been recently approved in India for the management of T2DM.This study was conducted to elaborate effect of SGLT2 inhibitor (remogliflozin) plus DPP4 inhibitor (vildagliptin) on diabetic nephropathy in patients of Type 2 DM.
Methods: This hospital based, comparative, open label, randomized controlled trial has been carried out in our department during January 2020 to October 2022 on 60 patients. Group 1 was given metformin 500 mg BD and glimepiride 1 mg BD and group 2 was given FDC of remogliflozin 100 mg and vildagliptin 50 mg BD with 32 patients in group 1 and 28 patients in group 2. The study was approved by ethical committee of our institute.
Results: Mean (SD) of urine ACR in metformin and glimepiride group at screening, 12 weeks, 24 weeks, and at 36 weeks were 93.64 (53.92), 95.56 (52.76), 89.96 (50.22) and 90.9 (53.56) respectively mean (SD) of urine ACR in remogliflozin and vildagliptin group at screening, 12 weeks, 24 weeks, and at 36 weeks were 108.28 (68.5), 100.73 (55.5), 99.35 (55.71) and 75.1 (38.7) respectively. Mean (SD) of eGFR in metformin and glimepiride group at screening, 12 weeks, 24 weeks, and at 36 weeks were 59.62 (18.57), 61.2 (11.1), 60.06 (14.37) and 60.8 (13.3) respectively. Mean (SD) of eGFR in remogliflozin and vildagliptin group at screening, 12 weeks, 24 weeks, and at 36 weeks were 68.03 (16.35), 65.8 (7.96), 66.28 (15.13) and 68.4 (11.6) respectively.
Conclusions: Remogliflozin and vildagliptin combination has significant reduction of proteinuria and eGFR improvement when compared to metformin plus glimepiride.
Investigation of the Relationship of Gynecological Cancer Awareness with Health Responsibility and Health Literacy
Authors: COŞKUN Sabahat 
Published: May 2023

Objective: Women's awareness of gynecological cancers is important for early diagnosis and screening. Health responsibility and health literacy can affect gynecological cancer awareness. Therefore, in this study, it was aimed to examine the relationship between women's gynecological cancer awareness and health responsibility and health literacy.
Methods: The study was designed as cross-sectional. Data were collected from 409 women aged 20-65 working in university units in Turkey between February 2021 and May 2021. In data collection, demographic information, obstetric, gynecologic, and general health characteristics of women, the Gynecological Cancer Awareness Scale (GCAS), the Turkish Health Literacy Scale (THLS-32) and the Health Promoting Lifestyle Profile II/ Health Responsibility Subscale were used. Descriptive, comparative and multiple regression analyzes were conducted.
Results: The total mean score of GCAS was 158.65±16.01 and 8.3% of the participants had insufficient health literacy. A significant regression model, F (df1=14, df2=394) =10.849, p< .001, and 25% of the variance in the dependent variable (R2adjusted = .25) was found to be explained by the independent variables. In the model, the variables that predict and contribute most to women's awareness of gynecological cancer are health responsibility (β= .21, t (394) = 4.35, p< .01), and THLS-32 (β= .20, t(394)= 4.33 , p< .01).
Conclusions: As a result, it is important to consider especially health responsibility and health literacy levels while developing intervention programs for women's awareness of gynecological cancer.
Rice-Body Synovitis, Foreign Body Reaction, and Rotator Cuff Failure After Subacromial Balloon Spacer Augmentation of a Rotator Cuff Repair
Authors: Fury Matthew S. , Cirino Carl M. , White Alex E. , Bauer Thomas W. , Taylor Samuel A. 
Published: May 2023

Case:
A 66-year-old woman presented with shoulder pain and weakness 4 months after augmentation of a rotator cuff repair with a Stryker InSpace subacromial balloon spacer. A magnetic resonance imaging (MRI) demonstrated a failed rotator cuff repair, large effusion with rice bodies, synovitis, axillary lymphadenopathy, loose anchors, and erosive changes to the greater tuberosity. Arthroscopy revealed balloon fragmentation surrounded by diffusely hyperemic synovium without repairable cuff tissue. Final cultures proved negative for infection. Histologic evaluation revealed ulcerated synovium with diffuse chronic and focal acute inflammation.

Conclusion:
Despite promising early results, augmentation of a rotator cuff repair with a subacromial balloon spacer introduces a risk of inflammatory reaction that may mimic a deep infection and compromise rotator cuff healing.
ALGORITMA C4.5 UNTUK PREDIKSI BIMBINGAN SISWA BERDASARKAN TIPOLOGI HIPPOCRATES-GALENUS
Authors: Boy Sandy Dwi Nugraha.H  , Defit Sarjon , Widi Nurcahyo Gunadi 
Published: May 2023

Jenis kepribadian yang dimiliki seorang siswa diyakini akan mempengaruhi prilakunya baik dalam hal positif atau negatif yang apabila dibiarkan akan merugikan siswa tersebut. Bimbingan siswa perlu dilakukan untuk memberikan arahan yang sesuai untuk siswa tersebut. Penelitian ini bertujuan untuk melakukan prediksi bimbingan siswa berdasarkan kepribadian dengan menggunakan data siswa di SMP 1 Negeri Tembilahan, proses pengumpulan data didapatkan dari guru BK di SMPN 1 Tembilahan untuk kelas 8 dan kelas 7. Kelas 8 akan digunakan sebagai data latih dan kelas 7 digunakan sebagai data uji. 5 parameter dipilih untuk proses prediksi dan 1 label sebagai kelas target. Metode yang digunakan adalah Alogritma C4.5 untuk membangun pohon keputusan dan mendapatkan rule-rule prediksi, Hasil penelitian dilakukan menggunakan pengujian Confussion Matrix dengan tingkat akurasi prediksi sebesar 70%. Tujuan akhir dari proses prediksi bimbingan siswa adalah hasil prediksi dengan persentasi Ya(perlu bimbingan) lebih besar dari Tidak(tidak perlu bimbingan), maka dapat dinyatakan model proses prediksi dengan Alogtima C4.5 layak digunakan sebagai penentetuan hasil keputusan yang baik dalam hal prediksi dan peneliti berharap setelah mendapatkan hasil tersebut diharapkan pihak Guru BK di SMPN 1 Tembilahan dapat melakukan proses bimbingan secepat mungkin dan memberikan bimbingan yang diperlukan oleh siswa yang membutuhkan.
Microplastic in Fishes: the First Report From a Himalayan River –alaknanda
Authors: Bhatt Vaishali , Badola Neha , Chauhan Jaspal Singh 
Published: May 2023

Abstract
In the present study, we tried to understand MPs ingestion by five fish species of different feeding habits namely, Schizothorax richardsonii and Crossocheilus latius (herbivore), Cyprinus carpio, Tor chelenoid (omnivore), and Botia horii (carnivore). The fishes were sampled from the patch of the Himalayan river, Alaknanda (one of the headwaters of river Ganges) at Srinagar, Garhwal, Uttarakhand. The fish gut samples were digested, filtered and the number of MPs was then counted microscopically. The results revealed that all the species were contaminated with MPs and the rate of MP ingestion varied with feeding habits. Fish Tor chelenoid, the omnivore, was observed to have maximum MPs. Among the analyzed particles, fibers (66%) were the most dominant type chemically characterized as HDPE, PP, and polyester. This study will contribute as a reference for forthcoming research as it explains the ingestion of MPs by fishes of a Himalayan River.
Lockdowns and Vaccines: Did Covid-19 Interventions Help Reduce the Long-Term Health Economic Consequences in Ghana?
Authors: Crankson Shirley , Mintram Kate , Pokhrel Subhash , Anagnostou Anastasia , Anokye Nana 
Published: May 2023

Abstract
COVID-19 has accounted for over 40,000 job losses and US$35 million in direct management costs in Ghana in 2021 with over 1,400 deaths so far. This study simulated the plausible long-term health economic consequences of COVID-19 and the scale of mitigation that lockdowns and vaccines could offer using the CoronAvirus Lifelong Modelling and Simulation (CALMS) algorithm, a published and fully validated agent-based model. The results showed that a whole population vaccination and periodic lockdown intervention could reduce the long-term COVID-19 infections, mortalities hospitalisations, long COVID and direct healthcare costs by more than 90% in the next ten years in Ghana. Among the simulated interventions, the whole population and periodic lockdown could be the most effective intervention. However, it could be the most expensive intervention (£291 million), followed by lockdowns (£251 million) and vaccinating clinically vulnerable populations (£42,115) at the end of the cohort’s lifetime. A periodic lockdown and whole-population vaccination could be the most effective intervention to reduce Ghana’s long-term COVID-19-related health economics outcomes. Increasing the whole population vaccination target alone could reduce Ghana’s long-term COVID-19 health economics outcomes. Future studies will need to look at wider outcomes (than just the health outcomes) to establish the full cost-benefit of these interventions.
SEATANI: hazards from seamounts in SouthEast Asia, Taiwan, and Andaman and Nicobar Islands (eastern India)
Authors: Verolino Andrea , Wee Su Fen , Jenkins Susanna , Costa Fidel , Switzer Adam 
Published: May 2023

Abstract
Submarine volcanism represents approximately 85% of volcanism taking place on Earth, and submarine eruptions can be particularly hazardous due to their potential to cause large-scale hazards from sector collapses, tsunamis, and ash dispersal. While recent eruptions in the Kingdom of Tonga and Japan have highlighted the significant hazards posed by submarine volcanoes, there has been little to no study of submarine volcanoes in Southeast Asia and its surroundings. Here we present and provide the SEATANI dataset, which compiles a list of 466 seamounts from the region, from different published sources. We characterized them in GIS, based on their shape and inferred evolution stage, which helped us to infer their past hazard history, and identified areas where the hazard posed by submarine volcanic eruptions is likely to be higher, based on exposure analyses. Our results show that there is a large number of potentially hazardous seamounts in this region, and Taiwan had the highest hazard and the highest exposure. Philippines, Indonesia and Vietnam were also found to have relatively high exposure. The results from this work serve as a first step for southeast Asian and neighbouring countries to become more resilient against and prepared for submarine volcanic eruptions in the region.
Efficacy of the Hongjing I granule herbal formulation in treating mild to moderate erectile dysfunction: A multicentre, randomized, double-blind, placebo-controlled clinical trial protocol
Authors: Xu Run-nan , Ma Jian-xiong , Lv Bo-dong 
Published: May 2023

Abstract
Background Erectile dysfunction (ED) is a common disease in male urology, and there is a single class of drugs used for its first-line treatment. Approximately 20% of patients do not experience improvement in overall sexual satisfaction (OS) after taking tadalafil. Currently, traditional Chinese medicine (TCM) is widely used as a complementary and alternative medicine (CAM) approach for ED patients. The Hongjing I granule (HJIG) herbal formula has shown good therapeutic effects on ED in preclinical studies. However, further evidence is needed to demonstrate its clinical efficacy and safety.Methods This study is a randomized, double-blind, placebo-controlled multicentre trial. A total of 100 patients diagnosed with mild to moderate ED caused by qi deficiency and blood stasis will be recruited and randomly assigned to receive one of two treatments: HJIG (N = 50) or placebo (N = 50). Patients will receive 8 weeks of treatment and a 16-week follow-up starting from the fourth week of treatment. Outcome measures, including the International Index of Erectile Function-Erectile Function domain (IIEF-EF) score, Sexual Encounter Profile (SEP), and Traditional Chinese Medicine symptom score, will be evaluated.Discussion This study is the first multicentre study to compare traditional Chinese herbal formulas with placebos in the treatment of ED. It aims to verify the improvement of TCM syndrome differentiation, erectile function, and sexual experience and to further broaden the treatment options for ED. The hypothesis is that HJIG can improve the erectile function score and sexual experiences of patients diagnosed with qi deficiency and blood stasis–type mild to moderate ED. This study may establish a new treatment for ED, distinct from other drugs used for similar clinical indications in clinical practice, and may provide high-quality reference evidence for its use as a complementary or substitute drug.Trial registration: Chinese Clinical Trial Registry, ChiCTR2000041127.
Application of Arc-SWAT model for water budgeting and water resource planning at the Yeralwadi catchment of Khatav, India
Authors: Sabale Ranjeet , Venkatesh B , Jose Mathew 
Published: May 2023

Abstract
Every facet of life, including human habitation, economic development, food security, etc., depends on water as a valuable resource. Due to burgeoning population and rapid urbanization water availability needs to be simulated and measured using hydrologic models and trustworthy data. To fulfill this aim, the SWAT model was processed in this work. The SWAT model was formulated to estimate the hydrological parameters of Yeralwadi using meteorological data from IMD (India Meteorological Department) for a period 1995–2020. The observed discharge data was collected from HDUG Nasik group and used in calibration and validation of Model. The SWAT model was corrected & validated through SUFI-II algorithm in SWAT-CUP to get a better result. The models sensitivity is checked by using statistical parameters like Nash-Sutcliffe Efficiency (NSE) and a coefficient of determination (R2). NSE values were 0.72 and 0.80 in calibration & validation, and R2 were 0.80 & 0.76 in calibration and validation respectively indicating the acceptance of model. Results show that 40.6% of the total yearly precipitation was lost by evapotranspiration. The estimated total discharge from Yeralwadi catchment was 55.6%, out of which 41.2% was surface runoff and 14.4% was baseflow. The other 17.8% was made up of percolation into confined and unconfined aquifers, which served as soil and groundwater storages. The surface runoff is influenced by Curve number (CnII), SOL_AWC, ESCO and base flow was influenced by ALPHA-BF and GW_REVAP. This study will be useful to water managers and researchers to develop the sustainable water resource management and to alleviate the water scarcity issues in study basin.
Bilateral Aspergillus Endophthalmitis Following Cataract Surgery: A Diagnostic and Therapeutic Challenge; Case Report
Authors: Johari Mohammadkarim , Abuali Mostafa , Razavizadegan Seyed Ahmad , Moallem Mehdi 
Published: May 2023

Abstract
Purpose: To describe a case of bilateral Aspergillus endophthalmitis occurring four months after bilateral cataract surgery manifesting as a spectacular filamentary branching on the IOL/capsular surface
Case presentation: A 66-year-old male known case of CLL, which had previously undergone bilateral cataract surgery in the same session, presented with bilateral decreased vision and vitreous haziness. Vitreous sampling showed aspergillus growth along with negative cytopathology and unremarkable systemic evaluation. Despite 23G deep-vitrectomy and initiation of systemic and intravitreal Voriconazole, a spectacular figure of filamentary branching growth on the IOL/capsular surface appeared in both eyes sequentially, which necessitated bilateral en bloc capsulectomy and IOL removal. Following further recurrence, the patient underwent re-deep vitrectomy, cryotherapy, and medication change to Amphotericin B, which led to a stable ophthalmic state up to this point.
Conclusion: Along with challenging diagnosis in chronic post-op fungal endophthalmitis, anti-fungal resistance, the patient’s immunosuppression, and delayed IOL/capsular removal may lead to a worse prognosis.
Cross-cultural adaptation and validation of the Moroccan Arabic version of the The Schizophrenia Quality of Life short-version questionnaire (SQoL-18)
Authors: Kachouchi Aymen , Sebbani Majda , Karroumi Saadia , Adali Imane , Manoudi Fatiha 
Published: May 2023

Abstract
Background Assessing quality of life (QoL) is an important aspect of the management of chronic diseases such as schizophrenia. However, there is no validated Moroccan specific QoL instrument for schizophrenia patients. This study aimed to adapt and assess psychometric properties of The Schizophrenia Quality of life questionnaire (SQoL-18).Methods We conducted a cross sectional study between May 2022 and October 2022 of 43 patients with schizophrenia attending the psychiatry department at the University hospital Mohamed VI Marrakech, Morocco. The SQoL-18 was translated into Moroccan Arabic language using the forward and backward translation method. The final version was tested for content validity by a panel of experts including psychiatrists and epidemiologists. Internal consistency analysis was performed by measuring Cronbach's alpha, and external validity by testing the correlations with the the Positive and Negative Syndrome Scale (PANSS), the Global Assessment of Functioning and WOOQOL-BREF.Results The Moroccan Arabic version of SQoL-18 was found to have satisfactory content validity. The global Cronbach's alpha was 0,866 and the specific Cronbach’s alpha for the dimensions of SQoL-18 were satisfactory except for one dimension (Self Esteem dimension). Higher QoL levels are globally associated with lower levels of severity of schizophrenia.Conclusion These results demonstrate satisfactory psychometric properties of the Moroccan Arabic version of SQoL-18.
Multilayer spherical shell nanodrug delivery system with spatiotemporal drug release improves tumor microenvironment for synergistic anticancer therapy
Authors: Cai Jiahui , Yang Yibo , Zhang Jia , Bai Zhimin , Zhang Xin , Li Kun , Shi Ming , Liu Zhiwei , Gao Liming , Wang Jidong , Li Jian 
Published: May 2023

Abstract
The inflammatory response is one of the general symptoms that accompany tumorigenesis, and the pro-inflammatory factors cyclooxygenase-2 (COX-2) and COX-2-derived prostaglandin-2 (PGE-2) in the inflammatory environment surrounding tumors possess promoting effects during tumor development，metastasis and angiogenesis. In addition, the hypoxic environment of tumors severely limits the effectiveness of photodynamic therapy (PDT). By using a spatiotemporal controlled Gelatin coated polydopamine (PDA@GN) as the carrier, and loaded with the chemotherapeutic drug doxorubicin (DOX), the photosensitizer indocyanine green (ICG), the PDT enhancer MnO2 and the anti-inflammatory drug celecoxib (CEL) individually, we developed an effective and universal extracellular-intracellular "on-demand" release nanomedicine DOX@PDA-ICG@MnO2@GN-CEL for the combined fight against malignant tumors. Our results showed that GN could release CEL extracellularly by MMP-2 response at tumor microenvironment (TME) and inhibit the COX-2/PGE-2 pathway, which could reduce chemotherapy resistance, attenuate the concurrent inflammation and the damage to surrounding normal cells of photothermal therapy (PTT) induced by PDA and ICG. After entering the tumor cells, PDA released DOX, ICG and MnO2 intracellularly through acid response. MnO2 promoted the degradation of endogenous H2O2 to generate oxygen under acidic conditions to alleviate the tumor hypoxic environment, which enhanced PDT triggered by ICG, PDA and ICG exhibited PTT synergistically, and DOX exerted chemotherapy with little chemotherapy resistance. The dual response drug release switch enabled the chemotherapeutic, photothermal, photodynamic and anti-inflammatory drugs precisely acted on different sites of tumor tissues and realized a promising multimodal combination therapy.
Extracellular Matrix Organization Genes Predict the Prognosis and Immune Microenvironment in Stomach Adenocarcinoma
Authors: Liu Qun , Wang Yan , Wang Kuo , Li Zhaoshui , Dong Quanjiang 
Published: May 2023

Abstract
Background
Extracellular matrix (ECM) dysregulation is crucial for malignant progression of human cancer. However, its effect on immune microenvironment of stomach adenocarcinoma (STAD) is unclarified.
Method
The Cancer Genome Atlas (TACG) database was utilized to retrieve STAD gene expression profiles and clinical information. Genes significantly associated with prognosis (P < 0.05) were assessed by univariate Cox regression. The Gene Ontology (GO) enrichment and protein-protein interaction (PPI) network were performed to identify the critical bioprocesses. Multivariate Cox regression and the least absolute shrinkage and selection operator (LASSO) were utilized to identify independent prognostic signature. Differentiating between clusters according to ECM organization gene expression (ECMOGs) was achieved by unsupervised clustering analysis. The biological characteristics in the ECMOGs clusters were determined. The tumor microenvironment (TME) features, including immunization checkpoint block (ICB) response, immune checkpoint genes, and tumor-infiltrating lymphocytes, were predicted between the distinct clusters.
Results
A total of 948 genes were identified as STAD prognostic genes. ECM organization was found to be the most significant bioprocesses these prognostic genes enriched in. Twelve ECMOGs were considered to be linked to the development of STAD. Three ECMOGs (ADAMTS1, LOX, NFKB2) were determined as independent predictor signatures for risk scoring. Based on twelve ECMOGs expression, the 348 patients were divided into cluster 1 and 2. Patients in cluster 1 had the higher levels of the detected ECMOGs and the risk score, as well as the poor prognosis. Cluster 1 was distinguished by its higher ICB response as well as the infiltrated M2 macrophage.
Conclusion
This study demonstrated that ECMOGs were associated with a bad prognosis partly by affecting the immune microenvironment, which could be the potential biomarker for the diagnosis and prognosis, and therapeutic target in STAD.
Epicatechin mediated modulation of the Nrf2/HO-1 pathway alleviates senile cerebral ischemic/reperfusion injury
Authors: Jiang Changyue , Xie lu , Hu wangxiang , zhuge xiangzhen , chen menghua , Li Deli 
Published: May 2023

Abstract
The aging of the global population has resulted in a significant increase in the incidence of stroke, disability, and mortality. Findings from numerous studies suggest that ROS generated during ischemic reperfusion are crucial in subsequent tissue damage. However, the role of nuclear factor-erythroid 2-related factor 2 (Nrf2), which regulates endogenous antioxidative functions, in pathological models of aging is not well understood. Our previous study showed that epicatechin (EC) upregulated brain Nrf2 expression in 2-month-old rats and reduced oxidative stress in cerebral ischemia-reperfusion injury (CIRI). In the present study, EC was administered to a 12-month-old rat model of CIRI (induced by middle cerebral artery occlusion and reperfusion) and a senescent SH-SY5Y cell model subjected to oxygen glucose deprivation/reoxygenation. EC treatment improved cerebral morphology and function; increased p-Nrf2 expression and unclear transportation and HO-1, SOD, and GSH expression; and reduced infarct volume and apoptosis in senescent rats. Moreover, EC enhanced cellular activity and the expression of p-Nrf2, HO-1, and NQO-1 while decreasing the ROS and MDA levels and mitigating apoptosis in senescent SH-SY5Y cells. These effects were attenuated upon si-Nrf2 introduction. The findings of this study offer novel insights into stroke prevention and therapy as well as drug development for the elderly population.