bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of butyrate‐producing enterobacteria on advanced hepatocellular carcinoma treatment with atezolizumab and bevacizumab
Authors: Nouso Kazuhiro , Shiota Shohei , Fujita Rio , Wakuta Akiko , Kariyama Kazuya , Hiraoka Atsushi , Atsukawa Masanori , Tani Joji , Tada Toshifumi , Nakamura Shinichiro , Tajiri Kazuto , Kaibori Masaki , Hirooka Masashi , Itobayashi Ei , Kakizaki Satoru , Naganuma Atsushi , Ishikawa Toru , Hatanaka Takeshi , Fukunishi Shinya , Tsuji Kunihiko , Kawata Kazuhito , Takaguchi Koichi , Tsutsui Akemi , Ogawa Chikara , Ochi Hironori , Yata Yutaka , Kuroda Hidekatsu , Iijima Hiroko , Matono Tomomitsu , Shimada Noritomo , Yasuda Satoshi , Toyoda Hidenori , Kumada Takashi ,   the Real‐life Practice Experts for HCC (RELPEC) Study Group and HCC 48 Group (hepatocellular carcinoma experts from 48 clinics in Japan)
Published: August 2023

AbstractAimMultiple studies have revealed the correlation between gut microbiome and the response to checkpoint inhibitors (CPIs) in patients with cancer, and oral administration of butyrate‐producing enterobacteria has been reported to enhance the efficacy of CPIs. However, the effects of enterobacteria on patients with hepatocellular carcinoma (HCC) are not well understood.MethodsIn this retrospective multicenter study, we enrolled 747 patients with advanced HCC, treated with atezolizumab and bevacizumab combination therapy. Tumor response, survival, and adverse effects were compared between 99 patients who ingested drugs containing butyric acid‐producing enterobacteria (butyric acid group) and the remaining patients (control group).ResultsObjective response and disease control rates in butyric acid group (29.7% and 77.8%, respectively) were higher than those in the control group (26.4% and 72.7%, respectively). However, the differences were not statistically significant (p = 0.543 and p = 0.222, respectively). No difference in median survival time was observed between the two groups (20.0 months and 21.4 months, respectively; p = 0.789), even after matching the backgrounds of the patients with propensity scores (p = 0.714). No adverse effects occurred upon the administration of butyrate‐producing bacteria. However, proteinuria (41.4% vs. 30.9%; p = 0.041), fever (17.2% vs. 10.2%, p = 0.036), and diarrhea (15.2% vs. 6.2%; p = 0.001) occurred more frequently in the butyric acid group.ConclusionButyrate‐producing bacteria does not enhance the efficacy of atezolizumab–bevacizumab combination therapy in patients with HCC.
VV‐ECMO as bridge and safety net for successful therapeutic polypragmasy in a case of influenza‐triggered near‐fatal asthma
Authors: Kowalewski Christoph , Schnürer Peter , Kopp Sabrina , Windschmitt Johannes , Oezkur Mehmet , Kriege Marc , Münzel Thomas , Kaes Joachim , Sagoschen Ingo , Wild Johannes 
Published: August 2023

Key Clinical MessageIn near‐fatal asthma, the combination of ECMO therapy and isoflurane application via an intensive care ventilator with an anesthetic conservation device represents a therapeutic combination in seemingly hopeless clinical situations.AbstractWe report a case of an adult patient with near‐fatal asthma, who was implanted venovenous extracorporeal membrane oxygenation in an extern hospital before transfer to our tertiary center. After 13 days and various therapeutic approaches, including inhaled isoflurane therapy via an anesthetic‐conserving device, the patient was decannulated and extubated 3 days later.
Intussusception in an elderly female and its management: A case report and literature review
Authors: Palle Lokeshwar Raaju Addi , Inban Pugazhendi , Akuma Ogbonnaya , Akuma Chinaza Mercy , Srirama Hema Anisha , Thakkar Keval , Hanafi Ihab Sheikh , Dahal Rojaj , Yousuf Mohammed Adnaan , Khan Aadil Mahmood , Kelechi Anasonye Emmanuel 
Published: August 2023

Key Clinical MessageIntussusception is the telescoping or invagination of the proximal part of the gastrointestinal tract into an adjacent section. It is rare in adults, accounting for 1% of adult bowel obstruction. Adult presentation of intussusception is variable, with nonspecific, vague symptoms like abdominal pain, nausea, vomiting, and rectal bleeding. Abdominal computed tomography (CT) scans have the highest sensitivity in the diagnosis of intussusception. The classical findings of intussusception are the target sign and mesenteric vessels lined within the bowel lumen. An abdominal CT scan can reveal a cloverleaf figuration, fluid‐filled ileal loops, superior mesenteric venous (SMV) occlusion, and concerns about ongoing sealed perforation or fistulization. Our patient is an 86‐year‐old female who was diagnosed with a jejunal–jejunal long‐segment intussusception, gastro‐enteric fistula, and SMV occlusion with distal reconstitution. The patient responded well to conservative treatment and was discharged for follow‐up.
A case of combined pulmonary vein isolation (PVI) and watchman implant through hepatic vein in a patient with interrupted inferior vena cava (IVC)
Authors: Girgis Sameh , Niknam Negar , Bhatti Zabeer , Mohsin Jalal , Aal Ahmed Kamel Abdel , Hariharan Ramesh , Hematpour Khashayar 
Published: August 2023

Key Clinical MessageThis case report describes a successful procedure involving pulmonary vein isolation (PVI) and left atrial appendage (LAA) closure with a watchman device in a 78‐year‐old male with atrial fibrillation and an interrupted inferior vena cava. Due to the vascular anomaly, a transhepatic approach was used, which proved successful.
Prognostic role of C‐reactive protein to albumin ratio in lung cancer: An updated systematic review and meta‐analysis
Authors: Lu Zhendong , Fu Siyun , Li Wei , Gao Xiang , Wang Jinghui 
Published: August 2023

AbstractBackgroundC‐reactive protein to albumin ratio (CRP/Alb ratio, CAR) has been suggested as a potential prognostic biomarker in lung cancer. This updated systematic review and meta‐analysis aimed to assess the association between CAR and lung cancer prognosis in current literature.MethodsA systematic search of databases was conducted to identify relevant studies published up to April 2023. Pooled hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated to assess the association between CAR and overall survival (OS) and progression‐free survival (PFS) and recurrence‐free survival (RF) in lung cancer patients.ResultsThis meta‐analysis includes 16 studies with a total of 5337 patients, indicating a significant association between higher CAR and poorer OS, PFS, and RFS in lung cancer patients, with a pooled HR of 1.78 (95% CI = 1.60–1.99), 1.57 (95% CI = 1.36–1.80), and 1.97 (95% CI = 1.40–2.77), respectively.ConclusionsThis updated meta‐analysis provides evidence for the potential prognostic role of CAR in lung cancer, suggesting its utility as an effective and noninvasive biomarker for identifying high‐risk patients and informing treatment decisions in a cost‐effective manner. However, further large‐scale studies will be necessary to establish the optimal cut‐off value for CAR in lung cancer and confirm the present findings.
Elucidating the Excited State Behavior of Pyridyl Pyridinium Systems via Computational and Transient Absorption Studies of Tetrahedral Multichromophoric Arrays and their Model Compounds
Authors: Ventura Barbara , Veclani Daniele , Venturini Alessandro , Armaroli Nicola , Baroncini Massimo , Ceroni Paola , Marchini Marianna 
Published: August 2023

AbstractThe tetrahedral shape‐persistent molecule 14+, containing four identical pyridyl pyridinium units connected via a sp3 hybridized carbon atom, has been investigated in detail by means of steady‐state and time resolved spectroscopy. Remarkable photophysical properties are observed, particularly in comparison with protonated and methylated analogues (1H48+, 1Me48+), which exhibit substantially shorter excited state lifetimes and lower emission quantum yields. Theoretical studies have rationalized the behavior of the tetrameric molecules relative to the monomers, with DFT and TD‐DFT calculations corroborating steady‐state (absorption and emission) and transient absorption spectra. The behavior of the monomeric compounds (each consisting in one of the four identical subunits of the tetramers, i. e., 2+, 2H2+ and 2Me2+) considerably differs from that of the tetramers, indicating a strong electronic interaction between the subunits in the tetrameric species, likely promoted by the homoconjugation through the connecting sp3 C atom. 2+ is characterized by a peculiar S1‐S2 excited state inversion, whereas the short‐lived emitting S1 state of 2H2+ and 2Me2+ exhibits a partial charge‐transfer character, as substantiated by spectro‐electrochemical studies. Among the six investigated systems, only 14+ is a sizeable luminophore (Φem=0.15), which is related to the peculiar features of its singlet state.
Multi‐responsive Electropolymer Surface Coatings Based on Azo Molecular Switches and Carbazoles: Light, pH, and Electrochemical Control of Z→E Isomerization in Thin Films
Authors: Gibalova Anna , Kortekaas Luuk , Simke Julian , Ravoo Bart Jan 
Published: August 2023

AbstractLight‐responsive surfaces are attracting increasing interest, not least because their physicochemical properties can be selectively and temporally controlled by a non‐invasive stimulus. Most existing immobilization strategies involve the chemical attachment of light‐responsive moieties to the surface, although this approach often suffers from a low surface concentration of active species or a high inhomogeneity of applied coatings. Herein, electropolymerization of carbazoles as a facile and rapid approach for preparing light‐responsive azo‐based surface coatings is presented. The electrochemical oxidative polymerization of bis‐carbazole containing azo‐monomers yields stable films, in which the photochemical properties and specific pH sensitivity of azo molecular switches are retained. Moreover, the molecular design enables electrocatalytic control over Z→E azo double bond isomerization facilitated by the conductive polycarbazole backbone. Ultimately, the high degree of control over macromolecular properties yields conductive surface coatings responsive to a range of stimuli, showing great promise as a strategy for versatile application in organic electronics.
Relationship between survivorship care plans and unmet information needs, quality of life, satisfaction with care, and propensity to engage with, and attend, follow‐up care
Authors: Hill Rebecca E. , Mercieca‐Bebber Rebecca , Fardell Joanna E. , Wakefield Claire E. , Signorelli Christina , Webber Kate , Cohn Richard J. ,   ANZCHOG Study Group
Published: August 2023

AbstractBackgroundThe impact of survivorship care plans (SCPs) on the proximal and distal outcomes of adult and childhood cancer survivors, and parent proxies, is unclear. This study aimed to determine the relationship between SCP receipt and these outcomes.MethodsA cross‐sectional survey of adult and childhood cancer survivors (and parent proxies for survivors aged younger than 16 years) across Australia and New Zealand was conducted. Multivariate regression models were fitted to measure the impact of SCP receipt on proximal (unmet information needs and propensity to engage with, and attend, cancer‐related follow‐up care) and distal outcomes (quality of life and satisfaction with cancer‐related follow‐up care) with control for cancer history and sociodemographic factors.ResultsOf 1123 respondents, 499 were adult cancer survivors and 624 were childhood cancer survivors (including 222 parent proxies). We found that SCP receipt was predictive of greater attendance at, and awareness of, cancer‐related follow‐up care (adult: odds ratio [OR], 2.46; 95% CI, 1.18–5.12; OR, 2.38; 95% CI, 1.07–5.29; child/parent: OR, 2.61; 95% CI, 1.63–4.17; OR, 1.63; 95% CI, 1.06–2.50; respectively). SCP receipt also predicted fewer unmet information needs related to “follow‐up care required” and “possible late effects” (adult: OR, 0.44; 95% CI, 0.20–0.96; OR, 0.29; 95% CI, 0.13–0.64; child/parent: OR, 0.46; 95% CI, 0.30–0.72; OR, 0.57; 95% CI, 0.38–0.85; respectively). In terms of distal outcomes, SCP receipt predicted a better global quality of life for adult cancer survivors (β, 0.08; 95% CI, −0.01–7.93), proxy‐reported health‐related quality of life (β, 0.15; 95% CI, 0.44–7.12), and satisfaction with follow‐up care for childhood cancer survivors (OR, 2.93; 95% CI, 1.64–5.23).ConclusionsPrevious studies have shown little impact of SCPs on distal end points. Results suggest that SCPs may be beneficial to cancer survivors’ proximal and distal outcomes.
Pneumocystis jirovecii pneumonia after CD4+ T‐cell recovery subsequent to CD19‐targeted chimeric antigen receptor T‐cell therapy: A case report and brief review of literature
Authors: Kawata Kento , Shima Haruko , Shinjoh Masayoshi , Yamazaki Fumito , Kurosawa Takumi , Yaginuma Mizuki , Takada Hiroshi , Shimada Hiroyuki 
Published: August 2023

AbstractBackgroundCD19‐targeted chimeric antigen receptor (CAR)‐T cell therapy involves administration of patient‐derived T cells that target B cells, resulting in B‐cell depletion and aplasia. In immunity against Pneumocystis jirovecii (Pj), CD4+ T cells and, more recently, B cells, are generally considered important. Antigen presentation by B cells to CD4+ T cells is particularly important. Trimethoprim‐sulfamethoxazole (TMP/SMX) for Pj pneumonia (PJP) prophylaxis is generally discontinued when the CD4+ T‐cell count is >200/μL. Here we report the first case, to our knowledge, of PJP in a patient with a CD4+ T cell count of >200/μL after CAR‐T cell therapy.CaseA 14‐year‐old girl developed hemophagocytic lymphohistiocytosis (HLH) after cord blood transplantation (CBT) for relapsed precursor B‐cell acute lymphoblastic leukemia (B‐ALL). Twenty‐one months after CBT, she was diagnosed with combined second relapse in the bone marrow and central nervous system. The patient was treated with CD19‐targeted CAR‐T cell therapy for the relapse. After CAR‐T cell therapy, the patient remained in remission and continued to receive TMP/SMX for PJP prophylaxis. Seven months after CAR‐T cell therapy, CD4+ T cells recovered and TMP/SMX was discontinued. The B‐cell aplasia persisted. Ten months after CAR‐T cell therapy, the patient developed PJP. The patient was also considered to have macrophage hyperactivation at the onset of PJP. Treatment with immunoglobulin, TMP/SMX, and prednisolone was initiated, and the patient's symptoms rapidly ameliorated.ConclusionThe patient in the present case developed PJP despite a CD4+ T‐cell count of >200/μL after CAR‐T cell therapy, probably because of inadequate CD4+ T‐cell activation caused by B‐cell depletion after CAR‐T cell therapy and repeated abnormal macrophage immune responses after CBT. It is important to determine the duration of TMP/SMX for prophylaxis after CAR‐T cell therapy according to each case, as well as the CD4+ T‐cell count.
Altered emotional response pattern related to complex trauma in patients with borderline personality disorder
Authors: Lopez‐Villatoro Jose M. , Diaz‐Marsa Marina , Garcia‐Ramos Adriana , Galvez‐Merlin Alejandra , Carrasco Jose L. 
Published: August 2023

AbstractIntroductionThis work aims to demonstrate, through the International Affective Picture System (IAPS) responses, an altered emotional pattern in borderline personality disorder (BPD) patients and to find a specific emotional response pattern by understanding their relationship with traumatic experiences and attachment bonds towards their primary caregivers.MethodA total of 50 BPD patients and 39 control patients were evaluated using the IAPS, and its assessment was carried out through the Self‐Assessment Manikin (SAM). Paternal and maternal attachment bonds as well as traumatic experiences in BPD patients were evaluated. Statistical associations were analysed in the different variables.ResultsSignificant differences between BPD and control patients were found in all emotional response components for pleasant, unpleasant and neutral images (p < .01), with one exception, the arousal in pleasant images. Patients' experience of traumatic experiences was positively related to scores on the happiness component of pleasant imagery (p = .057) and on the arousal component of unpleasant imagery (p = .058). Poorer maternal bonding in BPD patients was significantly related to lower scores on happiness (p < .01) and dominance (p < .05) components of pleasant imagery and all emotional response components for unpleasant imagery (p < .01).ConclusionsThe results of the study confirm an impaired emotional response pattern in patients with borderline personality disorder (BPD), showing an emotional response to pleasant images similar to that of depression, while the pattern found to unpleasant images could be related to the complex trauma observed in these patients, which includes PTSD experiences such as sexual abuse and attachment trauma experiences.
DNA isolation and genome sequence of the 134‐year‐old holotype specimen of Boletus subvelutipes Peck
Authors: Shumskaya Maria , Mironov Kirill S. , Ballesteros Jesús A. , Safonov Igor , Halling Roy E. 
Published: August 2023

AbstractMolecular characterization of type specimens is a powerful tool used in clarifying species identity/circumscription, as well as establishing the taxonomic and phylogenetic status of organisms in question. However, DNA sequencing of aged herbarium collections can be a challenge due to the quantity and quality of DNA still present in the specimens. Herein, we report a custom DNA isolation protocol suitable for processing minute quantities of old specimen tissue and its utilization via high‐throughput sequencing technologies to obtain, for the first time, the genome assembly of the 134‐year‐old holotype of Boletus subvelutipes Peck, a North American fleshy pored mushroom of taxonomic and historical significance. A side‐by‐side evaluation of our DNA isolation method with that of a commercial “kit” by Qiagen is also presented. By relying on the type material, we have established the genetic identity of B. subvelutipes, as well as providing preliminary phylogenetic evidence for its generic affinities in Neoboletus within Boletaceae. The reference genome of the B. subvelutipes holotype provides a resource for future comparative genomic studies, taxonomic revisions in Boletaceae, and other evolutionary studies of fungi.
High‐resolution diving data collected from foraging area reveal that leatherback turtles dive faster to forage longer
Authors: Migneault Amy , Bennison Ashley , Doyle Thomas K. , James Michael C. 
Published: August 2023

AbstractDespite multiple studies examining the diving behavior of leatherback sea turtles (Dermochelys coriacea) at coarse resolution over broad distances, there is still a paucity of high‐resolution diving data collected in areas where foraging has been confirmed. Short‐term (~1–3 h) deployments of suction cup tags with time–depth recorders (TDRs) on 10 free‐swimming leatherback turtles in a foraging area off Nova Scotia, Canada during August and September (2007–2014), captured a total of 161 dives. High‐resolution (1–5 s sampling rate) dive profile data indicated variability in diving behavior between and within individuals. On average, turtles spent 55.7% of their time diving and 44.3% at the surface. Turtles generally performed short (mean duration = 250.4 s [SD = 47.9 s]) and shallow dives (mean depth = 24.3 m [SD = 5.8 m]). We recorded a mean dive descent rate of 0.32 m/s, which is faster than values recorded for leatherbacks in tropical waters. This may reflect differences in environment, behavioral mode (e.g., foraging vs. inter‐nesting), and body condition. Linear mixed‐effects models suggest a significant positive correlation between descent rate and mean depth, maximum depth, and integrated vertical bottom movement (IVBM). Turtles with faster descent rates dove deeper and increased their predicted foraging behavior (IVBM, or the sum of absolute differences in depth changes while at the bottom portion of their dives). Models additionally showed that dive time, bottom time, and IVBM were all positively correlated to the post‐dive surfacing. This suggests that turtles required more time at the surface to recover and/or handle prey following longer dives characterized by increased vertical movement at the bottom portion of the dive. Dives were complex; the application of standard dive type/shape analysis may be over‐simplified and inappropriate for leatherbacks foraging in these habitats. These results portray a novel and detailed look at the foraging dynamics of a diving marine reptile.
Suppression of weed communities by granivores over time in an agroecosystem
Authors: Lundgren Jonathan G. , Anderson Randy L. 
Published: August 2023

AbstractInvertebrate granivore communities can consume numerous weed seeds in cropland, but how this granivory influences weed recruitment over time in continuous no‐till systems is unknown. Weed and surface‐active granivore communities were determined in soybeans (Glycine max) over 3 years in eastern South Dakota. We examined seed removal rates of sentinel redroot pigweed, green foxtail, and lambsquarters (Chenopodium album) seeds and applied gut content analysis of granivores to determine which species consume immuno‐marked seeds of green foxtail (Setaria viridis). Weed stands with low diversity and high biomass production were associated with granivore community complexity. In turn, granivore community complexity was associated with weed communities with low diversity and high biomass in the subsequent growing season. Fall seed consumption, as measured by seed removal rates and gut content analysis of foxtail seed markers, was positively correlated with weed recruitment in the subsequent growing season. Seed specialists behaved differently toward focal weed species than the granivore community at large. Gryllus pennsylvanicus abundance was correlated with higher green foxtail consumption and removal rates. None of the other dominant green foxtail consumers revealed a similar set of responses. We propose a feedback mechanism whereby granivore community complexity in cropland leads to larger but fewer weeds over multiple years. Weed communities with these characteristics then lead to more complex granivore communities. If these relationships persist over time with minimal disturbance in continuous no‐till cropping systems without pesticides, this feedback loop could reduce weed cover.
Synthesis and Characterization of Phosphate‐Catecholate Chelated Nd(III), Zr(IV), and Al(III) Complexes
Authors: Chen Ting , Ju Shaoying , Tong Mengnan , Zhao Yufen , Wu Yile , Stephan Douglas W. 
Published: August 2023

AbstractMetal phosphates are important catalysts and materials in synthesis chemistry. Herein, we describe the synthesis and characterization of phosphate‐catecholate chelated Nd(III), Zr(IV) and Al(III) chlorides (2–5). These species are achieved via ethyl chloride elimination reaction of oxophosphoranes with corresponding metal chlorides. The product 2–5 represent a new serial of monometallic and bimetallic phosphate‐catecholate chelated metal complexes stabilized by both P−O and catecholate‐O donors. These findings pave the way for future explorations of such species in catalysis.