bluuebunny/crossref_metadata_2025_split huggingface dataset:
A voltage lift‐based high‐gain DC‐DC converter with low input current ripple
Authors: Pratap Singh Amit , Tolani Sanjay 
Published: July 2023

AbstractThe switched‐inductor‐based voltage lift converters offer high voltage gain. However, their input current has step changes due to switched‐inductor configuration and is peaky due to the voltage lift capacitor charging current. This article proposes a new high‐gain DC‐DC converter where an additional boost converter cell is incorporated in a conventional voltage lift boost converter to charge the voltage lift capacitor with a constant current, avoiding a peaky charging current from the supply. The operating principle of the proposed converter demands phase‐shifted switching signals to achieve high voltage gain and reduce ripple in the input current. High‐gain, continuous input current, positive output voltage, common ground between input and output ports, and low voltage stress on active switches are the major characteristics of the proposed converter. The operating principle, steady‐state analysis, and control design have been discussed in detail. A 200 W, 30 V/300 V, and 50 kHz laboratory prototype is developed to validate the operation of the proposed converter.
Phthalimide as a versatile pharmacophore scaffold: Unlocking its diverse biological activities
Authors: Fernandes Guilherme F. S. , Lopes Juliana R. , Dos Santos Jean L. , Scarim Cauê B. 
Published: July 2023

AbstractPhthalimide, a pharmacophore exhibiting diverse biological activities, holds a prominent position in medicinal chemistry. In recent decades, numerous derivatives of phthalimide have been synthesized and extensively studied for their therapeutic potential across a wide range of health conditions. This comprehensive review highlights the latest developments in medicinal chemistry, specifically focusing on phthalimide‐based compounds that have emerged within the last decade. These compounds showcase promising biological activities, including anti‐inflammatory, anti‐Alzheimer, antiepileptic, antischizophrenia, antiplatelet, anticancer, antibacterial, antifungal, antimycobacterial, antiparasitic, anthelmintic, antiviral, and antidiabetic properties. The physicochemical profiles of the phthalimide derivatives were carefully analyzed using the online platform pkCSM, revealing the remarkable versatility of this scaffold. Therefore, this review emphasizes the potential of phthalimide as a valuable scaffold for the development of novel therapeutic agents, providing avenues for the exploration and design of new compounds.
Are threatened species special? An assessment of Dutch bees in relation to land use and climate
Authors: Moens Merijn , Biesmeijer Jacobus C. , Klumpers Saskia G. T. , Marshall Leon 
Published: July 2023

AbstractRed Lists are widely used as an indicator of the status and trends of biodiversity and are often used in directing conservation efforts. However, it is unclear whether species with a Least Concern status share a common relationship to environmental correlates compared to species that are on the Red List. To assess this, we focus here on the contribution and correlates of land use, climate, and soil to the occurrence of wild bees in the Netherlands. We used observation data and species distribution models to explain the relation between wild bees and the environment. Non‐threatened bees had a relatively higher variable importance of the land use variables to their models, as opposed to the climate variables for the threatened bees. The threatened bees had a smaller extent of occurrence and occupied areas with more extreme climatic conditions. Bees with a Least Concern status showed more positive responses to urban green spaces and Red List species showed a different response to climatic variables, such as temperature and precipitation. Even though Red List bees were found in areas with a higher cover of natural areas, they showed a more selective response to natural land use types. Pastures and crops were the main contributing land use variables and showed almost exclusively a negative correlation with the distribution of all wild bees. This knowledge supports the implementation of appropriate, species‐specific conservation measures, including the preservation of natural areas, and the improvement of land use practices in agricultural and urban areas, which may help mitigate the negative impacts of future global change on species' distributions.
Medication adherence and health‐related quality of life among people with diabetes in Bangladesh: A cross‐sectional study
Authors: Ahmed Sabrina , Saif‐Ur‐Rahman K. M. , Dhungana Raja Ram , Ganbaatar Gantsetseg , Ashraf Fatema , Yano Yuichiro , Miura Katsuyuki , Ahmed M. S. A. Mansur 
Published: July 2023

AbstractIntroductionGood adherence to anti‐diabetic medications is an important protective factor for decreasing diabetes‐related complications and disabilities but its association with health‐related quality of life (HRQoL) is understudied. The current study aimed to assess an association between medication adherence to anti‐diabetic drugs and HRQoL among people with diabetes in Dhaka city, Bangladesh.MethodsWe conducted a cross‐sectional study among 480 people with diabetes aged between 50 and 70 years, who attended a tertiary‐level hospital in Dhaka city. We used the EuroQol‐5 Dimensions Questionnaire (EQ‐5D‐5L) to measure HRQoL and Morisky Medication Adherence Scale to assess the level of medication adherence to anti‐diabetic drugs. Multivariable logistic regression was performed to assess the significance of relevant factors.ResultsThe mean age of the participants was 59.0 (standard deviation [SD], 7.0) years. The majority of the participants (74%) had a lower level of medication adherence. The mean value of (EQ‐5D‐5L) was 2.0 (SD, 1.0). The percentage of severe disability in different domains were 6.7% for mobility, 3.5% for self‐care, 11.9% for usual daily activities, 11.9% for pain/discomfort and 11.3% for anxiety. After adjusting for age, sex, years of education, household expenditure, hypertension, duration of diabetes, glycemic status and multi‐morbidities; low adherence to anti‐diabetic medication was inversely associated with pain (OR, 0.26; 95% CI, 0.08–0.80; p = .036), and positively associated with anxiety (OR, 7.18; 95% CI, 1.03–9.59; p = .043).ConclusionsLow medication adherence to anti‐diabetic drugs was associated with anxiety and pain among the EQ‐5D‐5L indexes measured in people with diabetes in Dhaka, Bangladesh.
Fit‐for‐Purpose Synthesis of CDK2 Inhibitor GNE‐140
Authors: Ambrosi Andrea , Piechowicz Katarzyna A. , Tuck Tyler A. , Xu Di , Zhang Haiming , Gosselin Francis 
Published: July 2023

AbstractA six‐step, stereoselective synthesis of cyclin‐dependent kinase 2 (CDK2) inhibitor GNE‐140 was developed. The key bonds were assembled through palladium‐catalyzed Negishi cross‐coupling and Buchwald–Hartwig C−N coupling steps. The stereodiad was established through a single‐step, CuH‐catalyzed enone reduction proceeding in >99 : 1 er and 89 : 11 dr. GNE‐140 was obtained in 25 % overall yield with 98.6 A% HPLC purity.
Evidencing the impacts of health research: Insights from trials reported in the 2018 Australian Engagement and Impact Assessment
Authors: Prowse Sarah R. , Treweek Shaun , Kiezebrink Kirsty , Hanna Catherine 
Published: July 2023

AbstractIssue AddressedWhile definitions of impact may vary, they often refer to the wider benefits of research evidenced beyond academia. We evaluated case studies featuring randomised trials from the 2018 Engagement and Impact Assessment to better understand how the impacts of health research are evidenced and assessed within Australia.MethodsWe collated and evaluated ‘high’ scoring case studies submitted by higher education institutions with a focus on randomised trials across all areas of health research. A qualitative coding system was used for manual content analysis to assess the key characteristics of trials reported, subsequent impacts and the methods used to evidence impacts.ResultsA total of 14 case studies were identified citing 35 clinical trials. The majority of interventions were behavioural with a focus on mental, behavioural or neurodevelopmental disorders. Most trials were phase III, focused on the treatment of the indication and were funded by industry. Contribution to clinical guidelines was the highest cited research impact. While there was evidence of researchers seeking to maximise trial impact, case studies lacked details on the role of trial participants and other beneficiaries in generating impact.ConclusionsThe impacts of health research can be improved through a better understanding of the priorities and agendas of funders, providing evidence of tangible impact rather than information that is contextual or predictive, and through the early development of impact strategies involving both researchers and beneficiaries.So What?Large‐scale impact exercises intended for a broad range of disciplines may not be reflective of the depth and scope of health sciences research including trials.
Applying multivariate techniques to fingerprint water quality impact of the Fundão Dam breach within the Rio Doce basin
Authors: Oehrig Jacob , Kananizadeh Negin , Wild Michael , Rouhani Shahrokh , Odle William 
Published: July 2023

Abstract
The Fundão Dam breach on 5 November 2015 (the “Event”) released tailings, water, soil and/or sediments, and other debris to downstream watercourses. This breach included both direct and indirect impacts from scouring of soils and sediments along and within the affected courses. Multivariate statistical techniques were used to determine the potential of fingerprinting the impact of the breach compared to pre-Event water quality conditions and unaffected watercourses. The selection of key parameters is an important first step for multivariate analyses. Analysis of too many parameters can mask important trends and relationships, while analysis of too few may miss significant water quality indicators. A two-phased selection process was used to identify key parameters that indicated impact from the Event: (a) unbiased, principal component analysis to extract chemically dominant profiles among all measured parameters and (b) comparison of metals' concentrations between unaffected soils and/or sediments and tailings samples. Radar charts of key parameters along with statistical comparisons to pre-Event and not-affected waterways were then aggregated over space and time to assess impact and potential recovery to pre-Event conditions. Nine parameters were identified that characterize tailings-related (direct) and background soil and/or sediment-related (indirect) impacts. Spatially and temporally aggregated radar charts and nonparametric Mann–Whitney U tests were used to assess the statistical significance of these impacts during each wet season since the breach. Indirect parameters, like aluminum and lead, returned to pre-Event levels in the first wet season after the Event. By the 2018/2019 wet season, most of the direct and indirect parameters had returned to pre-Event levels. Integr Environ Assess Manag 2024;20:133–147. © 2023 NewFields Companies, LLC. Integrated Environmental Assessment and Management published by Wiley Periodicals LLC on behalf of Society of Environmental Toxicology & Chemistry (SETAC).
Adenocarcinoma in ectopic prostatic tissue at the trigone of urinary bladder
Authors: Mori Shunsuke , Maekawa Takahiro , Kujime Yuma , Akiyama Mai , Matsushita Makoto , Sato Mototaka , Tei Norihide , Miyake Osamu 
Published: July 2023

IntroductionEctopic prostatic tissue is prostatic tissue located distant from the prostate gland. Although its existence is not uncommon, the occurrence of adenocarcinoma in ectopic prostatic tissue is rare.Case presentationA 68‐year‐old man was suspected to have a nodular‐type tumor in the bladder trigone and a tumor in the prostate based on magnetic resonance imaging and cystoscopy results. Transurethral tumor resection and transrectal prostate needle biopsy revealed the coexistence of ectopic prostatic adenocarcinoma in the bladder trigone and low‐risk orthotopic prostate cancer. Four years later, the tumor evolved to intermediate‐risk prostate cancer during active surveillance, and the patient underwent prostatectomy with resection of the bladder trigone. Pathology indicated no residual ectopic prostatic tissue or adenocarcinoma at the bladder trigone.ConclusionAdenocarcinoma in ectopic prostatic tissue is very rare; however, when found, the possibility of concurrent cancer in the prostate gland should be considered.
Natural overlaying behaviors push the limit of planar cyclic deformation performance in few‐layer MoS2 nanosheets
Authors: Li Peifeng , Zhang Guangjie , Kang Zhuo , Zheng Xin , Xie Yong , Liang Chunyuan , Zhang Yizhi , Fang Xiaoyang , Sun Rong , Liu Zhiquan , Bu Yeqiang , Lu Yang , Zhang Yue 
Published: July 2023

AbstractAs a typical two‐dimensional (2D) transition metal dichalcogenides (TMDCs) material with nonzero band gap, MoS2 has a wide range of potential applications as building blocks in the field of nanoelectronics. The stability and reliability of the corresponding nanoelectronic devices depend critically on the mechanical performance and cyclic reliability of 2D MoS2. Although an in situ technique has been used to analyze the mechanical properties of 2D materials, the cyclic mechanical behavior, that is, fatigue, remains a major challenge in the practical application of the devices. This study was aimed at analyzing the planar cyclic performance and deformation behavior of three‐layer MoS2 nanosheets (NSs) using an in situ transmission electron microscopy (TEM) variable‐amplitude uniaxial low‐frequency and cyclic loading–unloading tensile acceleration test. We also elucidated the strengthening effect of the natural overlaying affix fragments (other external NSs) or wrinkle folds (internal folds from the NS itself) on cycling performances and service life of MoS2 NSs by delaying the whole process of fatigue crack initiation, propagation, and fracture. The results have been confirmed by molecular dynamics (MDs) simulations. The overlaying enhancement effect effectively ensures the long‐term reliability and stability of nanoelectronic devices made of few‐layer 2D materials.image
Combined doxorubicin and arctigenin treatment induce cell cycle arrest‐associated cell death by promoting doxorubicin uptake in doxorubicin‐resistant breast cancer cells
Authors: Lee Min‐Gu , Lee Kyu‐Shik , Nam Kyung‐Soo 
Published: July 2023

AbstractChemotherapy failure is often caused by drug resistance, for which no effective treatment strategy has been established. Many studies have been undertaken with the aim of overcoming drug resistance using natural products. Arctigenin (ATG), a natural product, has been investigated for its anti‐cancer effects in HER2‐overexpressing, ER‐positive, and triple‐negative breast cancer cells. We investigated the efficacy of ATG against self‐established doxorubicin (DOX)‐resistant breast cancer cells (MCF‐DR and MDA‐DR cells) derived from MCF‐7 and MDA‐MB‐231 cells, respectively. ATG was found to increase DOX intracellular levels by downregulating multidrug Resistance 1 (MDR1) mRNA expression in DOX‐resistant cells. In addition, combined treatment with DOX and ATG (DOX/ATG) reduced the viability of and colony formation by DOX‐resistant cells. DOX/ATG also significantly induced G2/M cell cycle arrest by suppressing the Cyclin D1/CDK4/RB pathways and suppressed the expressions of MDR1 and Cyclin D1 by inhibiting the Mitogen‐activated protein kinase (MAPK)/Activating protein‐1 (AP‐1) signaling pathways. Furthermore, DOX/ATG induced DNA damage and attenuated the expressions of RAD51 and Ku80. However, PARP1 (Poly [ADP‐ribose] polymerase1) cleavage and AIF (Apoptosis‐inducing factor) induced apoptosis did not occur despite DNA damage‐induced cell death. Rather, flow cytometry showed that DOX/ATG caused necrosis. In summary, DOX/ATG increased intracellular DOX levels by inhibiting MDR1 and inducing G2/M arrest by inhibiting the Cyclin D1/CDK4/RB pathways and causing necrosis by damaging DNA. Our results suggest that ATG might be used as an adjuvant to enhance the efficacy of DOX in DOX‐resistant breast cancer.
Skeletal calcification patterns of batoid, teleost, and mammalian models: Calcified cartilage versus bone matrix
Authors: Pazzaglia Ugo E. , Reguzzoni Marcella , Milanese Chiara , Manconi Renata , Lanteri Luca , Cubeddu Tiziana , Zarattini Guido , Zecca Piero A. , Raspanti Mario 
Published: July 2023

AbstractThis study compares the skeletal calcification pattern of batoid Raja asterias with the endochondral ossification model of mammalians Homo sapiens and teleost Xiphias gladius. Skeletal mineralization serves to stiffen the mobile elements for locomotion. Histology, histochemistry, heat deproteination, scanning electron microscopy (SEM)/EDAX analysis, thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), and Fourier transform infrared spectrometry (FTIR) have been applied in the study. H. sapiens and X. gladius bone specimens showed similar profiles, R. asterias calcified cartilage diverges for higher water release and more amorphous bioapatite. In endochondral ossification, fetal calcified cartilage is progressively replaced by bone matrix, while R. asterias calcified cartilage remains un‐remodeled throughout the life span. Ca2+ and PO43− concentration in extracellular matrix is suggested to reach the critical salts precipitation point through H2O recall from extracellular matrix into both chondroblasts or osteoblasts. Cartilage organic phase layout and incomplete mineralization allow interstitial fluids diffusion, chondrocytes survival, and growth in a calcified tissue lacking of a vascular and canalicular system.Highlights
Comparative physico‐chemical characterization (TGA, DTG and DSC) testifies the mass loss due to water release, collagen and carbonate decomposition of the three tested matrices.
R. asterias calcified cartilage water content is higher than that of H. sapiens and X. gladius, as shown by the respectively highest dehydration enthalpy values.
Lower crystallinity degree of R. asterias calcified cartilage can be related to the higher amount of collagen in amorphous form than in bone matrix.
These data can be discussed in terms of the mechanostat theory (Frost, 1966) or by organic/inorganic phase transformation in the course evolution from fin to limbs.
Mineral analysis documented different charactersof R. asterias vs H. sapiens and X. gladius calcified matrix.
White epaxial muscle aerobic and anaerobic potential and muscle fiber structure in surface and cave morphotypes of the Mexican cavefish (Astyanax mexicanus)
Authors: Jiménez Ana Gabriela , Nash‐Braun Evan , Meyers Jason R. 
Published: July 2023

AbstractProper muscle function and muscle fiber structures that match the environmental demands of organisms are imperative to their success in any ecosystem. The Mexican cavefish, Astyanax mexicanus, has two morphotypes: an obligate cave‐dwelling form that lives in thermally insulated caves and an O2 poor environment, and a surface form that lives in a more thermally variable, but O2 rich river environment. As environment can determine physiological adaptations, it is of interest to compare the aerobic and anaerobic metabolic profiles of white muscle metabolism in both morphotypes of this species, as well as their muscle structures. Here, we used white muscle of both morphotypes of the Mexican cavefish to determine citrate synthase (CS) activity as a measure of aerobic potential, and lactate concentration as a measure of anaerobic potential at three different chronic acclimation temperatures (14°C, 25°C, and 31°C). By examining aerobic and anaerobic potential in both morphs, we sought to link environmental thermal flexibility to muscle metabolism. We found that the surface morphotype had higher CS activity and lower lactate concentration, suggesting an overall more efficient usage of aerobic metabolism; whereas the cave morphotype showed lower CS activity and higher lactate concentration, suggesting a stronger reliance on anaerobic pathways. We also measured white muscle histological variables that have been previously linked to whole‐animal metabolism: fiber diameter, number of nuclei per mm of fiber and myonuclear domain (MND) of both morphotypes at 25°C to examine cell‐level differences in muscle morphology. However, we found no differences in fiber diameter, number of nuclei per mm of fiber or MND between the two morphotypes. Thus, although the cellular morphology is similar in these species, the environmental differences in the evolution of the two morphs has led to differences in their metabolic profiles.
We can work it out: A multilevel examination of relationships among group and individual technology workarounds, and performance
Authors: Wei Shaobo , Chen Xiayu , Rice Ronald E. 
Published: July 2023

AbstractDespite the operational nature of enterprise system (ES) implementation and use, individual employees or work groups may deploy technology workarounds to circumvent inflexibility in or obstacles to using the ES. However, our understanding of the multilevel nature of technology workarounds and their performance implications remains limited. Drawing upon the multilevel theory of system usage and adaptive structuration theory, the current study examines the conditions under which group technology workarounds affect group performance, individual technology workarounds, and individual performance. Based on two studies with different research designs, we find that group technology workarounds have distinctive effects on short‐ and on long‐term group performance. Specifically, while the impact of group technology workarounds on group performance is significantly positive in the short term, such effect diminishes over time. System failure and competition intensity strengthen the positive effect of group technology workarounds on short‐term performance, whereas system failure and task nonroutineness lessen the negative effect of group technology workarounds on long‐term performance. Our study further confirms the multilevel nature of technology workarounds, finding that group technology workarounds can influence individual technology workarounds and thereby individual performance. Our results support the view that technology workarounds as a group action should be considered alongside individual technology workarounds, as well as their positive and negative effects on both group and individual performance, in both the short‐ and long‐term.
Customer base environmental disclosure and supplier greenhouse gas emissions: A signaling theory perspective
Authors: Song Sining , Lian Jie , Skowronski Keith , Yan Tingting 
Published: July 2023

AbstractAs suppliers' emissions contribute to a significant portion of the global environmental footprint, achieving supply chain wide carbon neutrality largely depends on suppliers' greenhouse gas (GHG) emissions reductions. Although suppliers' customers are increasingly signaling their commitment to tackling climate change through environmental disclosure, whether this signal contributes to supplier emissions reduction remains a question. Using signaling theory, this research proposes an emissions‐reducing effect of customer base environmental disclosure on a supplier's GHG emissions level. Using a 2010–2017 panel dataset from multiple sources, we find empirical evidence supporting the upstream emissions‐reducing effect of customer base environmental disclosure. Further, we identify two customer‐base characteristics that affect this relationship: customer base climate innovation and competition. These findings contribute to the sustainable supply chain management literature by illustrating the effects of the customer base on supplier emissions performance. Specifically, customers could motivate a supplier's engagement in emissions reduction by collectively signaling their environmental commitment through enhanced disclosure. However, the effectiveness of this signaling effect can be contingent on the green innovation and competitive dynamics of the customer base.