bluuebunny/crossref_metadata_2025_split huggingface dataset:
Leading co-production in five UK collaborative research partnerships (2008–2018): responses to four tensions from senior leaders using auto-ethnography
Authors: van der Graaf Peter , Kislov Roman , Smith Helen , Langley Joe , Hamer Natalie , Cheetham Mandy , Wolstenholme Daniel , Cooke Jo , Mawson Sue 
Published: January 2023

Abstract
Background
Despite growing enthusiasm for co-production in healthcare services and research, research on co-production practices is lacking. Multiple frameworks, guidelines and principles are available but little empirical research is conducted on ‘how to do’ co-production of research to improve healthcare services. This paper brings together insights from UK-based collaborative research partnerships on leading co-production. Its aim is to inform practical guidance for new partnerships planning to facilitate the co-production of applied health research in the future.

Methods
Using an auto-ethnographic approach, experiential evidence was elicited through collective sense making from recorded conversations between the research team and senior leaders of five UK-based collaborative research partnerships. This approach applies a cultural analysis and interpretation of the leaders’ behaviours, thoughts and experiences of co-production taking place in 2008–2018 and involving academics, health practitioners, policy makers and representatives of third sector organisations.

Results
The findings highlight a variety of practices across CLAHRCs, whereby the intersection between the senior leaders’ vision and local organisational context in which co-production occurs largely determines the nature of co-production process and outcomes. We identified four tensions in doing co-production: (1) idealistic, tokenistic vs realistic narratives, (2) power differences and (lack of) reciprocity, (3) excluding vs including language and communication, (4) individual motivation vs structural issues.

Conclusions
The tensions were productive in helping collaborative research partnerships to tailor co-production practices to their local needs and opportunities. Resulting variation in co-production practices across partnerships can therefore be seen as highly advantageous creative adaptation, which makes us question the utility of seeking a unified ‘gold standard’ of co-production. Strategic leadership is an important starting point for finding context-tailored solutions; however, development of more distributed forms of leadership over time is needed to facilitate co-production practices between partners. Facilitating structures for co-production can enable power sharing and boost capacity and capability building, resulting in more inclusive language and communication and, ultimately, more credible practices of co-production in research. We provide recommendations for creating more realistic narratives around co-production and facilitating power sharing between partners.
Extraction and concentration of nanoplastic particles from aqueous suspensions using functionalized magnetic nanoparticles and a magnetic flow cell
Authors: Surette Mark C. , Mitrano Denise M. , Rogers Kim R. 
Published: January 2023

AbstractAlthough a considerable knowledge base exists for environmental contamination from nanoscale and colloidal particles, significant knowledge gaps exist regarding the sources, transport, distribution, and effects of microplastic pollution (plastic particles < 5 mm) in the environment. Even less is known regarding nanoplastic pollution (generally considered to be plastic particles < 1 μm). Due to their small size, nanoplastics pose unique challenges and potential risks. We herein report a technique focused on the concentration and measurement of nanoplastics in aqueous systems. Hydrophobically functionalized magnetic nanoparticles (HDTMS-FeNPs) were used as part of a method to separate and concentrate nanoplastics from environmentally relevant matrices, here using metal-doped polystyrene nanoplastics (PAN-Pd@NPs) to enable low-level detection and validation of the separation technique. Using a magnetic separation flow cell, PAN-Pd@NPs were removed from suspensions and captured on regenerated cellulose membranes. Depending on the complexity of solution chemistry, variable extraction rates were possible. PAN-Pd@NPs were recovered from ultrapure water, synthetic freshwater, synthetic freshwater with a model natural organic matter isolate (NOM; Suwannee River Humic Acid), and from synthetic marine water, with recoveries for PAN-Pd@NPs of 84.9%, 78.9%, 70.4%, and 56.1%, respectively. During the initial method testing, it was found that the addition of NaCl was needed in the ultrapure water, synthetic freshwater and synthetic fresh water with NOM to induce particle aggregation and attachment. These results indicate that magnetic nanoparticles in combination with a flow-through system is a promising technique to extract nanoplastics from aqueous suspensions with various compositions.
Parallel repair mechanisms in plants and animals
Authors: Byatt Timothy C. , Martin Paul 
Published: January 2023

ABSTRACT
All organisms have acquired mechanisms for repairing themselves after accidents or lucky escape from predators, but how analogous are these mechanisms across phyla? Plants and animals are distant relatives in the tree of life, but both need to be able to efficiently repair themselves, or they will perish. Both have an outer epidermal barrier layer and a circulatory system that they must protect from infection. However, plant cells are immotile with rigid cell walls, so they cannot raise an animal-like immune response or move away from the insult, as animals can. Here, we discuss the parallel strategies and signalling pathways used by plants and animals to heal their tissues, as well as key differences. A more comprehensive understanding of these parallels and differences could highlight potential avenues to enhance healing of patients’ wounds in the clinic and, in a reciprocal way, for developing novel alternatives to agricultural pesticides.
Transhepatic or transperitoneal technique for cholecystostomy: results of the multicentre retrospective audit of cholecystostomy and further interventions (MACAFI)
Authors: Jenkins Paul Edward , MacCormick Andrew , Zhong Jim , Makris Gregory C , Gafoor Nelofer , Chan David ,   on behalf of the MACAFI Collaborators
Published: January 2023

Objective: This analysis of the MACAFI (multicentre audit of cholecystostomy and further interventions) data aims to assess the procedural technique and technical specifications related to percutaneous cholecystostomy (PC) insertion in patients with acute calculous cholecystitis (ACC). PC can be performed either with transperitoneal (TP) or a transhepatic (TH) approach. There is no clear evidence for the superiority of either technique. Methods: The data set included patients who underwent PC for ACC between first January 2019 and first January 2021. Data included patient demographics, imaging diagnosis, insertion technique, tube size, and outcomes including 6 month follow-up. Results: 1186 patients from 36 sites were identified through the MACAFI study with 913 patients having access route recorded. A transhepatic route was used in 572 [62.6%] compared to 308 TP [33.7%]. There was an increased rate of bleeding when using the TH route (2.6% vs 0.3%, p = 0.01) although other post-procedural complications (such as bile leak) were similar between the two groups. No significant difference was demonstrated in 30- or 90-day mortality (TH vs TP, 8.7vs 9.3%, p = 0.86 and 13.8vs 15.4%, p = 0.58, respectively). The readmission rate with recurrent cholecystitis was significantly greater in those with TH compared to TP approach (22.0% vs  14.9%, p = 0.01, respectively). Conclusion: The TP PC approach may be safer than TH, with lower bleeding complication rate and fewer readmissions. Advances in knowledge: A transperitoneal approach for cholecystostomy was associated with lower bleeding complication rate and lower rate of readmissions with recurrent cholecystitis compared to the transhepatic approach.
Point of Care Testing for SARS-COV-2 Antibodies before doing Endoscopy
Authors: Altaf Abeer , Abbas Zaigham , Qadeer Muhammad Ali , Siyal Mehreen 
Published: January 2023

Objectives: COVID-19 has taken the world by storm, creating much disparity among both healthcare and non-healthcare centres regarding the provision of services. The purpose of our study was to see the prevalence of the SARS-COV-2 exposure in the asymptomatic patients undergoing the endoscopic procedure, already triaged based on history and examination.
Methods: Total 207 patients were enrolled during a time period of five months during October 2020 to April 2021 at Dr. Ziauddin Hospital Clifton campus, Karachi. In this prospective observational study patients undergoing endoscopic procedures were included after taking informed consent. The patients who already tested positive for COVID-19 by PCR were excluded. Patients were tested for Covid serology by immunochromatographic rapid serology test (ICT). Standard Operating Procedures for dealing with endoscopy patients during the COVID era were followed in all patients irrespective of antibody status.
Results: Total number of patients included was 207; males were 121 (58.5%). The mean age was 48.5 ± 17.55 (range 13 to 92). Forty eight patients (23.2%) were positive for either antibody suggesting exposure to the COVID-19 virus. Out of these combined IgM and IgG positivity was seen in 24 (11.5%), IgM mono antibody positivity was seen in 7 (3.38%) and 17 (8.21%) of the study population tested positive for IgG only. 15 out of 46 (32.6%) patients with chronic liver disease in the cohort were seropositive for COVID antibodies.
Conclusion: About one-fourth of the patients undergoing the endoscopic procedure were tested positive for COVID antibodies of which a significant percentage had chronic liver disease. It stresses the need of observing standard precautions to prevent the spread of infection during these procedures, especially in the vulnerable population.
doi: https://doi.org/10.12669/pjms.39.2.5659
How to cite this: Altaf A, Abbas Z, Qadeer MA, Siyal M. Point of Care Testing for SARS-COV-2 Antibodies before doing Endoscopy. Pak J Med Sci. 2023;39(2):---------. doi: https://doi.org/10.12669/pjms.39.2.5659
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Neurofibromatosis Type-2 presenting with vision impairment
Authors: Alshoabi Sultan Abdulwadoud 
Published: January 2023

Neurofibromatosis Type-2 (NF2) is an autosomal dominant genetic tumour-predisposing condition caused by mutations in the NF2 gene located on chromosome 22q12. It is characterized by multiple benign tumours of the central and peripheral nervous systems and meninges, causing high morbidity. Herein, presentation of a rare case of NF2 in a 36-year-old female who presented with right eye visual disturbances, followed by tinnitus with hearing impairment. The visual disturbance developed into blindness. Magnetic resonance imaging (MRI) was performed, which showed a right-side cerebellopontine angle vestibular schwannoma and multiple meningiomas around the brain. According to the MRI findings, the patient was diagnosed with NF2. This case report aims to elucidate the importance of early brain imaging in any visual disturbances in young adults and to highlight the key role of medical imaging in the diagnosis of rare cases. Moreover, this describe the MRI features and the diagnostic accuracy for the tumours occurring in NF2 in detail.
doi: https://doi.org/10.12669/pjms.39.2.6813
How to cite this: Alshoabi SA. Neurofibromatosis Type-2 presenting with vision impairment. Pak J Med Sci. 2023;39(2):---------. doi: https://doi.org/10.12669/pjms.39.2.6813
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Development and identifying quantitative and quantities traits for breeding of Samae Dam Chicken (Gallus gallus), Thailand: Diversity of phenotypic characteristics
Authors: Wiyabot T , Kiattinarueyut S 
Published: January 2023

The objectives of this study were to the development and technology transfer for local production of Samae Dam Chicken (Gallus gallus) in Uthai Thani Province, Thailand by studying diversity of phenotypic characteristics in the rearing system. The average age of chickens was eight months, randomly numbered 1,000 in Uthai Thani Province. The results showed that variation of quantitative traits such as body weight, body height, body length, body width, wing length, shank length and toes length, the mean is equal to 3.0±0.25 kg/h, 58.5±0.10 cm, 24.5±0.30 cm, 14.5±0.20 cm 33.0±1.15 cm,10.25±0.5 cm and 5.75±0.45 cm respectively. The relationship between qualitative characteristics found that significant strong positive relationships between beak color and shank color (r=0.70; p<0.01), between necklace color and wings feather color (r=0.60; p<0.05), between necklace color and back- necklace color (r=0.15; p<0.01), between wings feathers color and necklace color (r=0.60; p<0.01), between wings feathers color and back-necklace color (r=0.25; p<0.01), between back-necklace color and necklace color (r=0.20; p<0.01), between back-necklace color and wings feather color (r=0.25; p<0.05) and between shank color and beak color. The relationship between quantitative characteristics all positive relationships among the studied quantitative traits was significant (r=0.30 to 0.55; p<0.01). The relationship between qualitative and quantitative factors in which the relationship between characteristics is significant (p<0.05). The positive correlation of beak color with body height (r=0.14), necklace color with bodyweight (r=0.15), necklace color with body width (r=0.17), wings feather color with body length (r=0.23), wings feather color with body width (r=-0.20), wings feather color with wing length (r=-0.14), tail feathers type with bodyweight (r=-0.25), tail feathers type with body height (r=-0.19), tail feathers type with body length (r=-0.26), tail feathers type with body width (r=-0.12), tail feathers type with wing length (r=-0.14), tail feathers type with shank length (r=-0.22), shank color with bodyweight (r=-0.22), shank color with body height (r=-0.18) and shank color with body length (r=-0.22). Effects of qualitative characteristics on quantitative characteristics of the chicken necklace color, wings feather color, back necklace color tail feathers type, shank color had significant difference (p<0.05).
Preliminary investigation of the nutritional composition of two commercial fish species: Rainbow trout (Oncorhynchus mykiss) and Atlantic salmon (Salmo salar)
Authors: Kocatepe D , Turan H , Köstekli B , Altan CO , Çorapci B 
Published: January 2023

In this study, it was aimed to compare of nutritional composition, cholesterol, trans fatty acids, fatty acids, lipid quality index, vitamins (A, B9, B2, B12, D3), selenium (Se), and iron (Fe) contents between farmed Atlantic salmon and rainbow trout. Crude protein, crude fat, carbohydrate, and energy values of Atlantic salmon were slightly higher than rainbow trout while crude ash and moisture values were higher in rainbow trout (p < 0.05). The cholesterol content of samples in rainbow trout and Atlantic salmon were found as 77.37±1.07 mg 100g-1 and 99.45±2.72 mg 100g-1, respectively (p<0.05). Trans fatty acids of both species were found as <0.3 g 100g-1. ƩSFA value of rainbow trout was found higher than the Atlantic salmon, on the other hand, the ƩMUFA values were found higher in the Atlantic salmon (p<0.05). However, the ƩPUFA values were found similar for both fish species (p>0.05). In general, the results show that rainbow trout contains two times more EPA+DHA amount than Atlantic salmon. While vitamin A has been found higher in rainbow trout, other vitamins (B9, B2, B12, D3) have been higher in Atlantic salmon (p<0.05). Additionally, iron (Fe) and selenium (Se) contents in rainbow trout has been significantly higher than Atlantic salmon (p<0.05).TRANSLATE with x EnglishArabicHebrewPolishBulgarianHindiPortugueseCatalanHmong DawRomanianChinese SimplifiedHungarianRussianChinese TraditionalIndonesianSlovakCzechItalianSlovenianDanishJapaneseSpanishDutchKlingonSwedishEnglishKoreanThaiEstonianLatvianTurkishFinnishLithuanianUkrainianFrenchMalayUrduGermanMalteseVietnameseGreekNorwegianWelshHaitian CreolePersian // TRANSLATE with COPY THE URL BELOW Back EMBED THE SNIPPET BELOW IN YOUR SITE Enable collaborative features and customize widget: Bing Webmaster PortalBack//
Mobile resistance determinants, plasmid replicon types and phylogeny among Escherichia coli strains isolated from cats and dogs
Authors: Kalaycı Yüksek F , Gümüş D , Macunluoğlu AC , Eroğlu E , Camadan D , Anğ Küçüker M 
Published: January 2023

Abstract
Multidrug resistance is a great challenge for the treatment of infectious diseases. We determined antibiotic resistance patterns, integrons, plasmid-mediated ESBL-, AmpC beta-lactamase-, carbapenemase-, colistin resistance genes, plasmid replicon types and phylogeny of fecal E. coli strains isolated from domestic cats and dogs in Turkey.
A total of 104 fecal samples of healthy 49 cats and 55 dogs were examined. The integrons, plasmid-mediated resistance genes, plasmid replicon types and phylogroups were determined by PCR. Antimicrobial susceptibilities were performed by disc diffusion and microdilution methods.

coli strains were mostly resistant to AMP (56.73%), SXT (39.42%), CTX (38.46%) and CIP (30.77%). Colistin resistance was not detected. ESBL and carbapenemase rates were 35.5 % and 7.69%, respectively. Eighty (76.9%) and 49 (47.1%) strains were harboring class I and class II integrons, respectively. Besides 12 strains were shown to possess class III integrons. The most frequently detected genes were blaCTX-M (48.08%), blaTEM (45.19%) and blaVIM (20.19%). In our study, none of strains were positive for mcr-1 and mcr-2 genes. Integrons were mostly found on plasmids of incompatibility groups IncF (71.25%) and strains bearing CTX-M and TEM carried a wide range of plasmid replicons of which IncF, IncFIB, IncK, and IncN. The majority of the strains were grouped in B2 (31.73%) and B1 (22.12%) and resistant bacteria mostly belonged to phylogroup B2.

We showed an increasing trend in ESBL-producing E. coli among fecal microbiota members. E. coli strains with different plasmid replicon types and phylogroups isolated from cats and dogs can be resistant to various antibiotics which are used in human and veterinary medicine.
Adaptive strategies for the deployment of rapid diagnostic tests for COVID-19: a modelling study
Authors: Cilloni Lucia , Kendall Emily , Dowdy David , Arinaminpathy Nimalan 
Published: January 2023

Background: Lateral flow assays (LFAs) for the rapid detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) provide an affordable, rapid and decentralised means for diagnosing coronavirus disease 2019 (COVID-19). Concentrating on urban areas in low- and middle-income countries, we examined whether ‘dynamic’ screening algorithms, that adjust the use of confirmatory polymerase chain reaction (PCR) testing based on epidemiological conditions, could reduce cost without substantially reducing the impact of testing. Methods: Concentrating on a hypothetical ‘second wave’ of COVID-19 in India, we modelled the potential impact of testing 0.5% of the population per day at random with LFA, regardless of symptom status. We considered dynamic testing strategies where LFA positive cases are only confirmed with PCR when LFA positivity rates are below a given threshold (relative to the peak positive rate at the height of the epidemic wave), compared to confirming either all positive LFA results or confirming no results. Benefit was estimated based on cumulative incidence of infection, and resource requirements, based on the cumulative number of PCR tests used and the cumulative number of unnecessary isolations. Results: A dynamic strategy of discontinuing PCR confirmation when LFA positivity exceeded 50% of the peak positivity rate in an unmitigated epidemic would achieve comparable impact to one employing PCR confirmation throughout (9.2% of cumulative cases averted vs 9.8%), while requiring 35% as many PCR tests. However, the dynamic testing strategy would increase the number of false-positive test results substantially, from 0.07% of the population to 1.1%. Conclusions: Dynamic diagnostic strategies that adjust to epidemic conditions could help maximise the impact of testing at a given cost. Generally, dynamic strategies reduce the number of confirmatory PCR tests needed, but increase the number of unnecessary isolations. Optimal strategies will depend on whether greater priority is placed on limiting confirmatory testing or false-positive diagnoses.
Smart5Grid Solutions for enhanced TSO grid observability and manageability in massive RES penetration environment
Authors: Shangov Daniel , Vlachkov Krassimir , Rumenova Ralitsa , Hristov Georgi , Velkov Atanas , Antonopoulos Angelos , Cadenelli Nicola , Tzanis Nikolaos , Brodimas Dimitrios , Rantopoulos Michalis , Chochliouros Ioannis , Vlahodimitropoulou Vasiliki 
Published: January 2023

Background This article elaborates on Horizon 2020 Smart5Grid Research and Innovation (R&I) project and reports the Smart5Grid Open Experimentation Platform (OEP), including its Open Service Repository (OSR), Verification and Validation (V&V), NetApp Controller (NAC), and Multi-access Edge Computing Orchestrator (MECO), as key results of this project. It then translates those results into energy vertical implications of the Smart5Grid for Transmission System Operators (TSOs), focusing on two particular Use Cases (UCs): UC3 Millisecond Level Precise Distribution Generation Control and UC4 Real-time Wide Area Monitoring pilot demonstrator of 5G virtual PDC capabilities for WAM of end-to-end electricity grids. More specifically, this work exhibits UC3 and UC4 NetApps developed as one of the key project deliverables. All use cases generate openly accessible data, except where specific security restrictions are applicable. Methods The Smart5Grid development methodology is based on the concept of Network Applications (NetApps). Their main mission is to hide the complexity of a 5G telco network for energy application developers in a way that empowers them to develop a NetApp without having to deal with the underlying network. A Virtual Infrastructure Manager (VIM) such as OpenStack or Kubernetes hosts every unit that composes a NetApp. The VIM provides monitoring data to a Network Function Vurtualisation Manager and Orchestrator (NFV MANO) framework, which airs information to the NAC that employs analysis algorithms to propose the optimal Virtual Network Function (VNF) and NetApp placing. A Slice Manager (SM) reserves resources for all these capabilities. Results The Smart5Grid architecture represents the main result that this work delineates in the context of its enhanced 5G telecommunication provider (telco) capabilities for transmission and distribution grids to face and manage more efficiently high Renewable Energy Sources (RES) penetration in a decarbonisation context.