bluuebunny/crossref_metadata_2025_split huggingface dataset:
Simulation of United States Mesoscale Convective Systems using GFDL’s New High-Resolution General Circulation Model
Authors: Dong Wenhao , Zhao Ming , Ming Yi , Krasting John P. , Ramaswamy V. 
Published: July 2023

Abstract
Accurate representation of mesoscale scale convective systems (MCSs) in climate models is of vital importance to understanding global energy, water cycles, and extreme weather. In this study, we evaluate the simulated MCS features over the United States from the newly developed GFDL global high-resolution (∼50 km) AM4 model by comparing them with the observations during spring to early summer (April–June) and late summer (July–August). The results show that the spatial distribution and seasonality of occurrence and genesis frequency of MCSs are reasonably simulated over the central United States in both seasons. The model reliably reproduces the observed features of MCS duration, translation speed, and size over the central United States, as well as the favorable large-scale circulation pattern associated with MCS development over the central United States during spring and early summer. However, the model misrepresents the amplitude and the phase of the diurnal cycle of MCSs during both seasons. In addition, the spatial distribution of occurrence and genesis frequency of MCSs over the eastern United States is substantially overestimated, with larger biases in early spring and summer. Furthermore, while large-scale circulation patterns are reasonably simulated in spring and early summer, they are misrepresented in the model during summer. Finally, we examine MCS-related precipitation, finding that the model overestimates MCS-related precipitation during spring and early summer, but this bias is insufficient to explain the significant dry bias observed in total precipitation over the central United States. Nonetheless, the dry biases in MCS-associated precipitation during late summer likely contribute to the overall precipitation deficit in the model.
Atmospheric Modeling Study on Convection-Triggered Teleconnections Driving the Summer North American Dipole
Authors: Bai Husile , Strong Courtenay 
Published: July 2023

Abstract
The summer North American dipole (NAD) is a pattern of climate variability linked to variations in boreal forest seed production and migration of seed-eating birds. This is a modeling investigation of two teleconnections identified as drivers of the NAD in prior observational work: 1) tropically sourced atmospheric Rossby waves associated with anomalies in the phase distribution of the Madden–Julian oscillation (MJO) (i.e., phases 1 and 6 are anomalously prominent), and 2) a pan-Pacific atmospheric Rossby wave linked to East Asian monsoonal (EAM) convection. Sea surface temperature (SST) boundary forcing experiments were conducted with the Community Earth System Model 2 (CESM2) to trigger convection patterns that align with those observed during EAM and nonuniform phase distributions of MJO. For the EAM case, an El Niño–like SST dipole pattern combined with cool southern Japan SST forcing produced a convection and jet stream shift anomaly over East Asia and the northern Pacific with a positive NAD pattern downstream over North America, similar to the observed pattern when precipitation over East Asia (PEA) is relatively high. A companion experiment with only ENSO-like SST forcing also produced the NAD but featured a different structure over the Eurasian continent with a response resembling the summer east Atlantic (SEA) pattern over eastern North America and the eastern Atlantic. Simulation results suggest that the southern Japan SST forcing region has a secondary importance in triggering the NAD, producing only a somewhat NAD-like pattern by itself and only slightly improving the NAD produced by ENSO-like forcing. Simulations using SST forcing to induce seasonal convection anomalies with spatial patterns similar to anomalously frequent occurrence of MJO phase 1 (phase 6) produced circulation response patterns resembling the positive NAD (negative NAD).
Source strengths obtained with three clean air suits fulfilling the requirements for high performance in EN 13795-2:2019: An experimental study
Authors: Ljungqvist Bengt , Reinmüller Berit , Tammelin Ann 
Published: July 2023

Introduction Clothing made from tight material worn by operating room staff adds to the effect achieved by ventilation in the effort to keep a low level of bacteria in the operating room air. The material used for clean air suits should be tested according to the standard EN 13795-2. Aim The aim of the study was to investigate whether there was a difference in protective capacity between three clean air suits made from materials fulfilling the requirements of EN 13795-2:2019 and designed as described in Annex E of the standard. Materials and methods Eight people (five men and three women) performed standardized movements in a dispersal chamber with a fixed supply air flow. Each person performed two test cycles with each clean air suit. Counts of colony-forming units (CFU) in the air were measured during testing and source strength was calculated for each test cycle. Results The mean values of source strength for the three clean air suits were 1.4 CFU/s, 0.8 CFU/s and 0.7 CFU/s. The difference between the most and the least protective garment was statistically significant (p < 0.05). Conclusions Clean air suits made from material fulfilling the requirements for ‘high performance’ in the standard EN 13795-2:2019 might show a significant difference in protective capacity when comparing source strength. Tests for measuring of source strength in a dispersal chamber can be performed as suggested in Annex E of the standard, i.e. ‘The test person is male, 20–50 years old, with no visible skin disorder’.
Aortic valve replacement for moderate aortic stenosis during mitral surgery improves survival free from severe stenosis
Authors: Weingarten Noah , Rekhtman David , Iyengar Amit , Song Cindy , Patel Mrinal , Atluri Pavan 
Published: July 2023

Background Optimal management of moderate aortic stenosis during surgery for another indication is unclear. We assessed the effects of surgical aortic valve replacement for moderate aortic stenosis during mitral surgery. Methods An institutional mitral surgery database was queried for patients with preoperative moderate aortic stenosis. Patients were stratified by whether they underwent concomitant surgical aortic valve replacement. Morbidity was analyzed using Student's t tests, Wilcoxon rank sum, chi-squared, and Fisher's exact tests. Survival was analyzed using Kaplan–Meier estimation and Cox regression. Results Of 85 mitral surgery recipients with moderate aortic stenosis from 2012 to 2019, 62 (73%) underwent concomitant surgical aortic valve replacement. Surgical aortic valve replacement recipients were more likely to have bicuspid (11% vs. 0%, p  =  0.019) or rheumatic (18% vs. 0%, p  =  0.019) aortic valves, and to undergo mitral repair (32% vs. 9%, p  =  0.028). Groups did not differ with respect to mitral etiology, New York Heart Association class, or cardiac intervention history ( p > 0.05). Postoperatively, groups had similar stroke and gastrointestinal bleed rates (3% vs. 0% and 2% vs. 0% in the surgical aortic valve replacement vs. no surgical aortic valve replacement group respectively, both p > 0.99). Five-year survival free from severe aortic stenosis was higher in the surgical aortic valve replacement group (66% vs. 17%, p  =  0.002). Surgical aortic valve replacement protected against the composite of death and progression to severe aortic stenosis at 5 years (hazard ratio: 0.32, p  =  0.003). Conclusions Surgical aortic valve replacement for moderate aortic stenosis at time of mitral surgery is a well-tolerated strategy to reduce aortic disease progression.
A process evaluation of a health promotion intervention to increase breakfast consumption in children
Authors: Lu Yanming 
Published: July 2023

Background This study, part of a community-based nutrition study, aimed to understand the participating experiences of a one-month health promotion intervention in children and parents. The intervention aimed at prompting breakfast consumption amongst children. The specific intervention strategies consisted of mobile text messaging relating to how to cook nutritious and fast breakfast, breakfast-related cartoons provided for children, and group information sessions relating to breakfast consumption for parents. Methods This study, a process evaluation, conducted 30 individual semi-structured interviews. Results Text messaging may be a feasible delivery modality to promote breakfast consumption in children. The extensive contact intensity or amount of intervention strategies may have an adverse impact on prompting breakfast consumption. Disease- and risk-related educational content has the potential to promote breakfast consumption in children. Conclusion Text messaging shows promise in increasing breakfast consumption in children, with careful design of contact intensity of educational intervention strategies warranted in the intervention planning process. Content related to the side-effects of breakfast skipping has the potential to promote breakfast consumption in children. However, future research is required to fully understand the quality and effectiveness of these intervention strategies, employing quantitative methodologies.
Outcomes in patients with BRAFV600–mutated melanoma and brain metastases at baseline treated with dabrafenib plus trametinib
Authors: Aglietta Massimo , Chiarion-Sileni Vanna , Fava Paolo , Guidoboni Massimo , Depenni Roberta , Minisini Alessandro , Consoli Francesca , Ascierto Paolo Antonio , Rinaldi Gaetana , Banzi Maria , Marconcini Riccardo , Gueli Rossana , Ferraresi Virginia , Tucci Marco , Tonini Giuseppe , Lo Re Giovanni , Guida Michele , Del Vecchio Michele , Marcon Ilaria Gioia , Queirolo Paola 
Published: July 2023

Background: Brain metastases (BM) and lactate dehydrogenase (LDH) levels above the upper limit of normal (ULN) are associated with poor prognosis in patients with melanoma. Although treatment with the BRAF inhibitor dabrafenib and the MEK inhibitor trametinib have demonstrated long-term clinical benefit in patients with melanoma, data on their efficacy in patients with BM are limited. Methods: DESCRIBE Italy is an observational, retrospective, real-world study evaluating dabrafenib plus trametinib in 499 patients with BRAFV600-mutant stage III unresectable or stage IV melanoma from various sites across Italy. Here, we analyzed the clinical outcomes for the subgroup of patients receiving first-line treatment and presenting with BM at diagnosis and assessed the impact of predictive factors such as LDH levels and the presence of other metastases on median progression-free survival (mPFS). Results: Overall, 325 evaluable patients were on first-line therapy and are the focus of this analysis; of these, 76 patients (23.4%) had BM at baseline. mPFS was lower for patients with BM at baseline compared with overall patients (8.7 months vs 9.3 months, respectively). Patients with BM at diagnosis and LDH >ULN had a considerably shorter mPFS compared with patients with LDH ⩽ULN (5.3 months vs 9.9 months, respectively). mPFS was noticeably longer for patients with cerebral metastases only compared with patients with cerebral and other metastases (15.0 months vs 8.7 months, respectively). Conclusions: Dabrafenib plus trametinib showed effectiveness in a real-world population of patients with advanced BRAFV600-mutated melanoma and BM at baseline, supporting its use in this population with poor outcomes.
Experimental and numerical investigation on the hydraulic design criteria for a step-pool nature-like fishway
Authors: Kalathil Sruthi T , Chandra Venu 
Published: July 2023

Hydraulic considerations specific for the design of step-pool nature-like fishways (NLFs) are limited to the body dimensions of the target species. Additional hydraulic criteria for flow depth, maximum values for each of pool depth, velocity, and turbulent kinetic energy in terms of the weir opening width and discharge can help design an optimum step-pool NLF. The present study developed design charts and rating curves based on numerical modeling using the computational fluid dynamics software FLOW-3D® HYDRO. Instantaneous velocity measurements on a 1:4 scaled physical model of a step-pool nature-like fishway designed as per the available design guidelines have been used to validate the numerical model. The hydrodynamics of the fishway with respect to the weir opening ratio b r (0.10, 0.25, 0.45, 0.65, and 1.00) and discharge Q (0.1–1.5 m3/s) was analyzed through numerical simulations on a prototype scale. The simulation results showed that the maximum flow velocity and the averaged velocity over the crest at b r = 0.10 and 0.25 are considerably lower than at b r > 0.25. The maximum turbulent kinetic energy and energy dissipation factors for the tested range of discharges were within recommended limits for b r = 0.10 and 0.25. The present study outcome in terms of the design charts and rating curves that illustrate the relationship between different variables can be used for an optimum design and ease in field implementation. In addition, the bed structure of the step-pool NLF presented in this study can be used to recreate full-scale or pilot models.
Impact of carbon information disclosure on corporate financing constraints: Evidence from the Carbon Disclosure Project
Authors: Huang Heshu , Zou Yuchen , Wang Liukai , Wang Weiqing , Ren Xiaohong 
Published: July 2023

With peak carbon dioxide emissions and a carbon-neutral background, the initiative of enterprises to disclose information voluntarily is insufficient, this study attempts to study the impact of carbon information disclosure on financing constraints to encourage companies’ carbon information disclosure. Previous literature usually uses a binary variable to measure whether an enterprise participates in Carbon Disclosure Project (CDP), and rarely study the impact of carbon information disclosure on economic consequences by acquiring all CDP levels manually. And most of these theories are mostly based on developed countries. Based on the whole sample of 1293 Chinese listed companies participating in the CDP from 2016 to 2020, this study employed the oversampling technology to end unbalanced CDP data, then an ordinary least squares (OLS) regression to account for time-invariant industry heterogeneity and time trends is employed. The empirical results indicate that the higher the CDP level, the smaller the financing constraints of enterprises. Moreover, the channel analysis indicates that carbon information disclosure is alleviating financing constraints by reducing information asymmetry and enhancing corporate reputation. This study bridges the gap in existing research on alleviating corporate financing constraints through the emerging CDP, which also presents the detailed implications for companies and policy makers. JEL Classification: G14; G20; M14; Q51
Early Postoperative Complications and Associated Variables After High Tibial Osteotomy and Distal Femoral Osteotomy: A 15-Year Experience From a Single Academic Institution
Authors: Berk Alexander N. , Gachigi Kennedy K. , Trofa David P. , Piasecki Dana P. , Fleischli James E. , Saltzman Bryan M. 
Published: July 2023

Background: High tibial osteotomy (HTO) and distal femoral osteotomy (DFO) are well-recognized treatments to address varus and valgus malalignment, respectively, in the setting of symptomatic unicompartmental arthritis of the tibiofemoral joint. The existing literature is limited in its ability to characterize complications after HTO or DFO procedures. Purpose: The objective of this study was to determine the rate of early (≤90 days) postoperative complications and associated variables from the 15-year experience of a single academic institution. Study Design: Case series; Level of evidence, 4. Methods: Patients treated at a single academic institution between 2008 and 2022 who underwent HTO or DFO procedures were identified. All patients with minimum 90-day follow-up were considered for inclusion in the study. Exclusion criteria were inadequate follow-up, unavailable medical records, age <14 years, and revision osteotomy. Patient demographic characteristics, surgical history, and concomitant procedures were identified, and risk factor analysis was performed to identify variables associated with early postoperative complications. All intraoperative complications were recorded. Results: A total of 243 knees in 232 patients met eligibility and were included in the final analysis. Three intraoperative complications (1.2%) involving fracture extension of the osteotomy occurred. There were 127 early postoperative complications (121 surgical, 6 medical) in 102 knees (68 with HTO and 34 with DFO). Medical complications included pulmonary embolus in 3 patients (1.2%), urinary tract infection in 2 patients (0.8%), and postoperative ileus requiring prolonged hospitalization in 1 patient (0.4%). The most common complications were stiffness requiring a non–standard of care intervention (17.7%), superficial wound infection or wound dehiscence (13.2%), and hemarthrosis or effusion requiring aspiration (6.6%). The rate of deep infection requiring irrigation and debridement was 4.1%. Variables associated with early postoperative complications included smoking (odds ratio [OR], 3.05; 95% CI, 1.34-6.94; P = .008), concomitant chondroplasty and/or loose body removal (OR, 2.55; 95% CI, 1.50-4.33; P = .001), and concomitant ligament reconstruction (OR, 3.97; 95% CI, 1.37-11.53; P = .011). Conclusion: These 15-year data revealed a low rate of intraoperative complications (1.2%) and a relatively high rate of early (≤90 days) postoperative complications (42.0%) after an HTO or DFO procedure. Surgeons should be aware of the increased postoperative complications associated with smoking, concomitant chondroplasty, and concomitant ligament reconstruction and should use this information to counsel patients regarding appropriate expectations in the postoperative period.
Discordance Between Invasive and NonInvasive Oxygen Saturation in Critically Ill COVID-19 Patients
Authors: Fox Thomas H. , Mazalewski William R. , Tran Hai S. , Lindsey Travis , Krishnan Amita , Kantrow Stephen P. , Happel Kyle I. , Janz David R. , deBoisblanc Bennett P. , Lammi Matthew R. 
Published: July 2023

Objectives To investigate discordance in oxy-hemoglobin saturation measured both by pulse oximetry (SpO2) and arterial blood gas (ABG, SaO2) among critically ill coronavirus disease 2019 (COVID-19(+)) patients compared to COVID-19(-) patients. Methods Paired SpO2 and SaO2 readings were collected retrospectively from consecutive adult admissions to four critical care units in the United States between March and May 2020. The primary outcome was the rate of discordance (|SaO2-SpO2|>4%) in COVID-19(+) versus COVID-19(-) patients. The odds each cohort could have been incorrectly categorized as having a PaO2/FiO2 above or below 150 by their SpO2: Fractional inhaled oxygen ratio (pulse oximetry-derived oxyhemoglobin saturation:fraction of inspired oxygen ratio [SF]) was examined. A multivariate regression analysis assessed confounding by clinical differences between cohorts including pH, body temperature, renal replacement therapy at time of blood draw, and self-identified race. Results There were 263 patients (173 COVID-19(+)) included. The rate of saturation discordance between SaO2 and SpO2 in COVID-19(+) patients was higher than in COVID-19(-) patients (27.9% vs 16.7%, odds ratio [OR] 1.94, 95% confidence interval [CI]: 1.11 to 2.27). The average difference between SaO2 and SpO2 for COVID-19(+) patients was −1.24% (limits of agreement, −13.6 to 11.1) versus −0.11 [–10.3 to 10.1] for COVID-19(–) patients. COVID-19(+) patients had higher odds (OR: 2.61, 95% CI: 1.14-5.98) of having an SF that misclassified that patient as having a PaO2:FiO2 ratio above or below 150. There was not an association between discordance and the confounders of pH, body temperature, or renal replacement therapy at time of blood draw. After controlling for self-identified race, the association between COVID-19 status and discordance was lost. Conclusions Pulse oximetry was discordant with ABG more often in critically ill COVID-19(+) than COVID-19(–) patients. However, these findings appear to be driven by racial differences between cohorts.
Awareness, Knowledge, and Attitude About Sensory Processing and Its Disorders: An Online Survey Among Student Speech-Language Pathologists
Authors: Nair Anagha Reghu , Geetha Arya 
Published: July 2023

Background: There is not much known about how speech-language pathology students address the sensory processing issues of children in their clientele. Understanding sensory processing disorders (SPD) will help Speech-Language Pathologists (SLP) to understand the root cause of the behavior, avert meltdowns, how to tackle the situation better, and to give adequate referrals so that better progress can be made in intervention. Aims: This study aimed at assessing the awareness knowledge and attitude about sensory processing and its disorders among student SLPs from Tamil Nadu, India. Methods & Procedures: A questionnaire was developed and validated, which was used for an online survey among student SLPs. A total of 110 students participated in the study. Outcomes & Results: Although students of speech-language pathology have some awareness about SPD, they lacked thorough understanding of sensory difficulties associated with other neurodevelopmental disorders, which interfered with the implementation of sensory-based activities during therapy. Conclusions and Implications: This study provides clinical significance in the field of speech-language pathology, particularly for SLP who work with children experiencing developmental difficulties.
Genicular Artery Embolization: A Promising Treatment Option for Recurrent Effusion Following Total Knee Arthroplasty
Authors: Lutz Rex W. , Post Zachary D. , Thalody Hope S. , Czymek Miranda M. , Ponzio Danielle Y. , Kim Christopher E. , Ong Alvin C. 
Published: July 2023

Background: Selective genicular artery embolization (GAE) has shown promise as a minimally invasive treatment option for persistent symptomatic recurrent effusions (REs) following total knee arthroplasty (TKA). Purpose: We sought to investigate the radiographic and clinical success of GAE for RE after TKA. Methods: We performed a retrospective review of prospectively collected data on primary and revision TKA patients with RE, both hemorrhagic and non-hemorrhagic, who underwent GAE between 2019 and 2021 with a minimum of 6-month follow-up. All embolization procedures were performed by a single interventional radiologist. Western Ontario and McMaster University Osteoarthritis Index (WOMAC) and visual analog scale (VAS) scores were collected prior to GAE and at 1, 3, and 6 months post-procedure. Recurrence of effusion following GAE was assessed at 6 months using ultrasound. Results: Seventeen patients, 10 female and 7 male, with 18 TKAs and a mean (SD) age of 63.1 (8.6) years were included. We saw a mean (SD) of 36.1 (24.4) and 3.3 (3.0) point improvement in WOMAC and VAS scores, respectively. In addition, 14 of the 18 TKAs (77.8%) seen at final follow-up had complete resolution of effusion confirmed by ultrasound. Conclusion: Our retrospective review found that a majority of patients showed significant clinical improvement and resolution of effusion following GAE. These findings suggest that GAE may be an effective minimally invasive treatment option for RE following TKA and should be further investigated.