bluuebunny/crossref_metadata_2025_split huggingface dataset:
Continuous‐Flow Enantioselective 1,4‐Addition Reactions of Malonates with Nitroolefins on Ni‐Supported Mesoporous Silica Materials with Co‐feeding of a Chiral Ligand
Authors: Ishitani Haruro , Kanai Kan , Kobayashi Shū 
Published: March 2023

AbstractA catalytic system is described in which achiral Ni is immobilized on mesoporous silica material with external addition of a chiral modifier enabling continuous‐flow enantioselective reactions with catalyst‐packed bed reactors. Continuous‐flow enantioselective 1,4‐addition reactions of dimethyl malonate with nitroalkenes proceeded with co‐feeding of a chiral diamine ligand, and the corresponding products were obtained in high yields with high enantioselectivities for more than 80 h with a turnover frequency of 3.1 h−1 based on [Ni].
Recent Advances in Multicomponent Organic Composite Thermoelectric Materials
Authors: Bao Yuanrong , Sun Yajing , Jiao Fei , Hu Wenping 
Published: March 2023

AbstractOrganic thermoelectric materials have the potential to be used as power supplies for wearable electronics, implantable medical devices, and sensors in Internet of Things. The past 10 years has witnessed the rapid development of the research on organic thermoelectric materials, different material systems and optimizing strategies are developed, and the ZT values of some organic materials have approached that of many inorganic thermoelectric material systems in the low‐temperature region. Among different material systems, organic composite materials, especially multicomponent organic composite materials show very promising thermoelectric properties and offer more tunability compared to single component thermoelectric materials. Multicomponent organic composite thermoelectric materials can not only further improve the ZT values, but also have unique advantages of combining the merits of different materials, thus rendering the composites with better processing, mechanical, or other properties on demand. This review summarizes the concepts, the design criteria, the research progress of organic–inorganic and all‐organic multicomponent thermoelectric materials which contain three or more different ingredients, as well as their applications. Furthermore, the challenges and prospects are also analyzed to provide guidelines for the development of multicomponent organic composite thermoelectric materials.
Dihydropyrimidinones as potent anticancer agents: Insight into the structure–activity relationship
Authors: Prasad Tanya , Mahapatra Aastha , Sharma Tripti , Sahoo Chita R. , Padhy Rabindra Nath 
Published: March 2023

AbstractCancer is a serious disease that has been around for a long time but currently has no sustainable solution. Several medications currently available offer an opportunity for the manifestation of cancer treatment; however, the “search for better” has led to the development and study of a variety of new scaffolds. Dihydropyrimidinones (DHPMs) are a privileged scaffold, prominent for their versatile range of biological activities. In recent years, the anticancer potential of these unsaturated pyrimidine ring systems has been traversed, along with their synthesis methods and the interlinked mechanisms leading to the anticancer activity. This review summarizes the structure–activity relationship of DHPMs as potential anticancer agents. This study is a short review of their synthesis, mechanism of action, and structure–activity relationships (SARs) that are answerable for the anticancer activity of DHPMs and have been thoroughly researched and assessed.
Recent advances, perspectives and challenges on levulinic acid production from residual biomass
Authors: Bazoti Suzana F. , Bonatto Charline , Scapini Thamarys , Camargo Aline Frumi , Treichel Helen , de Oliveira Débora 
Published: March 2023

AbstractOver the years, several studies have focused on integrally exploring lignocellulosic biomass to achieve satisfactory yields of different bioproducts and establish economically viable industrial processes. Among the bioproducts, levulinic acid (LA) has emerged as one of the top platform products derived from biomass, mainly owing to its expanding market economic position, which can stimulate viability and attract the attention of investors in the field. Considered a building block because of its versatile intermediate chemical structure, it can be used to synthesize many compounds with applications in fuels, pharmaceutical and cosmetics industries, food additives and solvents. The main synthesis route for obtaining LA is the degradation of cellulose via acid catalysis. In this context, lignocellulosic biomass is a promising and sustainable way of getting LA. Recent research has explored a potential path to full technological development associated with LA from various biomass and different catalysts. In this scenario, a comprehensive review concerning biomass for LA production and the challenges in the synthesis process is proposed. The primary studies conducted over the years and approaches to using and appreciating residual biomass are also discussed. This work also considers the use of technological tools to optimize the production of LA and seeks to contribute sustainable proposals still little explored, such as the intensification of the process and the use of fruit residues in the synthesis of this promising building block. © 2023 Society of Industrial Chemistry and John Wiley & Sons Ltd.
A grounded theory of improvisation in therapy: Lessons from decoloniality
Authors: Blunden Nicola 
Published: March 2023

AbstractGrounded theory (GT) is a popular research methodology that has been used in various fields and disciplines. Its researchers face the paradox of their method being grounded in both data and theory, potentially resulting in researcher ambivalence towards existing knowledge and constructing “thin” or “descriptive” theory as a result. In this reflective paper, the researcher uses a case example of theorising the category “improvisation,” to explore the deliberate decolonial use of literature in GT. They share detailed examples of inductive coding, analytic memoing and abduction of the category. They describe a paradigm‐changing moment of realisation when they discovered their own colonial thinking towards this category and the subsequent perspective change that occurred when they attempted to “de‐link” from their colonial thinking and apply a decolonialised lens to their category. The work of Black and Indigenous authors enabled the researcher to theorise “improvisation” as a valid, transdisciplinary practice that lies at the heart of both therapy and art making. The researcher concludes that researchers intending to decolonialise their knowledge production should take a critical‐reflexive stance towards existing theory, deliberately seeking out alternate, decolonial ways of knowing, in order to construct more vital, convivial and emancipatory theories. They also offer a decolonial reimagining of therapy as a grounded, responsive, intentional and social improvisational practice, which is co‐created between client and therapist.
Nonthermal Plasma‐Assisted CO2‐H2O Conversion over NiO and Co3O4 Supported on CeO2
Authors: Bajpai Abhinav , Kumar Sushant 
Published: March 2023

AbstractTransformation of CO2 into value‐added chemicals remains a key challenge. Herein, nonthermal plasma (NTP)‐activated CO2‐H2O conversion over BaTiO3‐mixed NiO/CeO2 (Ni/Ce+) and Co3O4/CeO2 (Co/Ce+) catalysts is demonstrated. In a continuous‐flow dielectric barrier discharge reactor and under ambient conditions, optimum Co/Ce+ showed formation rates of CO and O2 of (43.6 ± 3.1) and (20.8 ± 0.7) μmol g−1h−1, respectively. CO2 conversion was found to be dependent on a combination of the basicity of the catalyst surface, CO2 flow rate, plasma input power, and relative humidity. Subsequently, kinetic analysis suggested that the activation energies over Ni/Ce+, Co/Ce+, and NiCo/Ce+ are 35.68, 15.61, and 25.88 kJ mol−1, respectively. By combining these findings, a plausible reaction mechanism that can facilitate understanding the trend of product formation is also provided.
The modeling of multicancer early detection (MCED) tests’ residual risk and the challenges of MCED evaluation and implementation
Authors: Kessler Larry , Le Beau Michelle M. , Smith Robert A. , Walter Fiona M. , Wender Richard 
Published: March 2023

Multicancer early detection (MCED) tests represent a potentially game‐changing early cancer detection technology. Modeling efforts, such as those of Hudnut et al. in this issue of Cancer, as well as systematic clinical studies and data collection, along with public health and primary care efforts, need to be undertaken to determine whether MCED tests become an opportunity to decrease the heavy burden of cancer for all.
Dosing Recommendation Based on the Effects of Different Meal Types on Pexidartinib Pharmacokinetics in Healthy Subjects: Implementation of Model‐informed Drug Development Strategy
Authors: Zahir Hamim , Yin Ophelia , Hsu Ching , Wagner Andrew J. , Jiang Jason , Wang Xiaoning , Greenberg Jon , Shuster Dale E. , Kakkar Tarundeep , LaCreta Frank 
Published: March 2023

AbstractPexidartinib, an oral small molecule inhibitor of the colony‐stimulating factor 1 receptor, is approved for treatment of adults with symptomatic tenosynovial giant cell tumor associated with severe morbidity or functional limitations and not amenable to improvement with surgery. The original dosing regimen is 400 mg of pexidartinib (2 × 200‐mg capsules) twice daily, administered on an empty stomach at least 1 hour before or 2 hours after a meal or snack. Because pexidartinib is likely to be taken over an extended period of time, the ability to take pexidartinib with a meal would simplify timing of administration and potentially improve compliance. Since administering 400 mg of pexidartinib with a low‐fat meal increases exposure by ≈60% relative to the fasted state, administering 250 mg of pexidartinib with a low‐fat meal (low‐fat meal dosing regimen) was predicted to achieve an exposure similar to 400 mg administered during a fasted state (original dosing regimen). Based on clinical trial simulations with two one‐sided t‐tests and bootstrapping (ie, resampling) analyses, a bioequivalence study (n = 24) would have >90% power to conclude that the original dosing regimen (400 mg fasted twice daily) and the low‐fat meal dosing regimen (250 mg with a low‐fat meal twice daily) are bioequivalent. This report provides the outcome of the implementation of the model‐informed drug development strategy to recommend and justify a low‐fat meal dosing regimen for pexidartinib that has the potential to improve patient compliance while maintaining drug exposure.
Crystal Structure of Gd(Ca3.319Sr0.681)O[BO3]3 and Gd(Ca2.592Sr1.408)O[BO3]3
Authors: Weigel Tina , Mehner Erik , Stöcker Hartmut , Meyer Dirk C. , Götze Jens , Hanzig Juliane 
Published: March 2023

AbstractThe structure family of the rare‐earth calcium oxoborates O[BO3]3 (RCOB) has been investigated mainly with regard to their optical characteristics. Due to their monoclinic‐domatic structure they exhibit pyro‐ and piezoelectric properties, which is not dependent on the numerous possible substitutions of the rare‐earth cation site R. The rare‐earth cations are known to show partial disorder with the earth alkaline cation positions X and Z. To study whether a stabilization of the cation occupation is possible without disorder, calcium oxoborates are chemically modified using the Ca substitutes, Sr, Na, Y, Gd on the X and Z positions. No oxoborate phases can be synthesized by coupled substitution of Ca with Sr, Na, and a rare‐earth element. Only with single substitution of Sr the oxoborate phases can be synthesized. It is found that up to 35% Sr can be incorporated into the structure. From the synthesized Gd(CaSrx)O[BO3]3 precursor material, single crystals have been grown and used for the refinement of the first structure model. The structures have been refined in space group . A replacing only of Ca with Sr, mainly on the X position, has been observed. The stoichiometry resulting from the refinement is Gd(Ca3.319Sr0.681)O[BO3]3 and Gd(Ca2.592Sr1.408)O[BO3]3.
A 7.6–12.3 GHz wide‐band PLL with an ultra low reference spur −81.1 dBc in 0.13 μm CMOS technology
Authors: Li Jinwei , Sun Bing , Huang Jiawei , Chang Hudong , Jia Rui , Liu Honggang 
Published: March 2023

AbstractThis paper presents a wide‐band charge‐pump phase‐locked loop (CPPLL) with reference spur reduction techniques. To broaden the frequency range without deteriorating phase noise, a 6‐bit capacitor array‐based VCO and an automatic frequency calibrator (AFC) are used. A compact loop filter technique saves the capacitor area and maintains the bandwidth. Also, a novel charge pump with dynamic current matching circuit is proposed to reduce the reference spur of the PLL. The current mismatch is less than 0.22
A (0.16%) over the voltage range from 0.75 to 1.55 V. Fabricated in 0.13
m CMOS technology, the proposed PLL achieves a locking range of 7.6–12.3 GHz (47.2%), with a 25 MHz frequency interval. The PLL consumes 23.3 mA from a 2.5 V supply voltage and occupies a core area of 0.92 mm
0.72 mm. The reference spur of the proposed PLL is measured to be −81.1 dBc, and in‐band phase noise reaches −110.8 dBc/Hz at 1 MHz offset frequency from the 9.5 GHz carrier frequency.
Genetic algorithm‐based partial charging schedule of rechargeable sensor networks
Authors: Dudyala Anil Kumar , Dash Dinesh 
Published: March 2023

SummaryThe use of rechargeable sensors is a promising solution for wireless sensor networks. On this type of network, mobile charging vehicles (MC) are used for charging sensors using wireless energy transfer (WET) technology. In on‐demand charging, a sensor transmits a charging request to the service station, and the MC visits the sensor to transfer energy. The key disadvantages of utilizing MC‐based WET are its high energy expenditure rate due to mobility, long service time, and slow charging rate. Because of these reasons, sensors deplete their energy and become dead before the MC reaches the requesting nodes to recharge. We have adapted a genetic algorithm‐based partial charging scheme to serve the charging requests. Our objective is to improve the survival ratio of the network. Using comprehensive simulations, we analyze the performance of our proposed method and compare it to two other existing approaches. The simulation results demonstrate that our proposed algorithm improves the survival ratio by up to 20 % by developing a dynamic energy threshold function for transmitting charging requests from the sensors and a partial charging schedule using a genetic algorithm.
Does perceived support moderate the link between acculturative stress and problematic eating behaviors? The role of family, significant other, and friend support
Authors: Wang Peiyi , Garcia Esmeralda R. , Chen Chuansheng , Yim Ilona S. 
Published: March 2023

AbstractObjectiveAcculturative stress, often experienced by members of minority groups, is related to problematic eating behaviors. What remains poorly understood is the function of perceived social support in this link. This study evaluated the moderating role of perceived support from family, the significant other, and friends in the association between acculturative stress and problematic eating behaviors, including emotional eating, uncontrolled eating, and cognitive restraint eating.MethodAn online cross‐sectional study was conducted with 497 Asian and Latinx college students using standardized questionnaires. Three hierarchical multivariable models were analyzed, with each eating behavior included as the outcome variable. Demographic variables (Step 1), general perceived stress (Step 2), and predictor variables (i.e., acculturative stress, perceived support; Step 3) were added using Method Enter. Interaction terms were entered using Method Stepwise (Step 4) to test for moderation effects.ResultsAs perceived family support increased, the magnitude of the link between acculturative stress and higher uncontrolled eating increased (p = .002). When perceived significant other support was higher, the magnitude of the relationship between acculturative stress and higher emotional eating increased (p = .02). Higher perceived friend support was directly related to reduced uncontrolled eating (p = .002).DiscussionThis study highlights the heterogeneous effects of various sources of perceived support on the link between acculturative stress and problematic eating behaviors. Findings imply that problematic eating prevention and intervention programs might benefit from considering not only the acculturative stress experienced by racial/ethnic minority young adults but also the sources of support perceived.Public SignificancePerceived support from family and the significant other increased the magnitude of the link between higher acculturative stress and increased problematic eating behaviors, whereas support from friends showed a direct relationship with reduced uncontrolled eating. The results highlight the nuanced functions of various sources of perceived social support and contribute to a deeper understanding of potential moderators in the relationship between acculturative stress and problematic eating behaviors among racial/ethnic minorities.
Multistage hierarchical capture–recapture models
Authors: Hooten Mevin B. , Schwob Michael R. , Johnson Devin S. , Ivan Jacob S. 
Published: March 2023

AbstractEcologists increasingly rely on Bayesian methods to fit capture–recapture models. Capture–recapture models are used to estimate abundance while accounting for imperfect detectability in individual‐level data. A variety of implementations exist for such models, including integrated likelihood, parameter‐expanded data augmentation, and combinations of those. Capture–recapture models with latent random effects can be computationally intensive to fit using conventional Bayesian algorithms. We identify alternative specifications of capture–recapture models by considering a conditional representation of the model structure. The resulting alternative model can be specified in a way that leads to more stable computation and allows us to fit the desired model in stages while leveraging parallel computing resources. Our model specification includes a component for the capture history of detected individuals and another component for the sample size which is random before observed. We demonstrate this approach using three examples including simulation and two datasets resulting from capture–recapture studies of different species.
Seismic performance evaluation of high‐post‐yield stiffness concentrically braced steel frames under mainshock‐consistent‐aftershock sequences
Authors: Hassan Mahmoud , Sipcic Nevena , Vasdravellis George 
Published: March 2023

AbstractStructures may be subjected to earthquake sequences after major mainshock (MS) events in seismically active sites within a short time. As a result, they may be susceptible to damage accumulation, which may hinder their performance under consecutive seismic loading. This study evaluates the effects of earthquake sequences on the seismic performance of seismic‐resistant concentrically braced steel frames designed to Eurocode‐8. The frames under investigation have concentric chevron‐type braces with replaceable hourglass‐shaped pins made of duplex stainless steel. The seismic energy is dissipated through inelastic deformations concentrated in the pins while keeping the other members elastic. The stainless‐steel pins provide the frame with high‐post‐yield stiffness to reduce the residual drifts after a seismic event. The seismic behaviour of the frame is assessed using site hazard‐specific mainshock‐consistent‐aftershock (MS‐AS) sequences selected for a site in Terni, Central Italy. Nonlinear back‐to‐back dynamic analyses are performed at multiple intensity levels while adopting detailed numerical nonlinear models created in OpenSees. We show that the implemented behaviour factor satisfies the life safety assurance objective while keeping the maximum residual inter‐storey drifts below 1/300 to permit an easy substitution of the damaged pins after the design‐level earthquake without being curtailed by the potential following events. We then develop prediction models for the damage accumulation in the pins, considering different energy‐based intensity measures and we show that the cumulative absolute velocity‐based model is the most efficient predictor in this particular case. Finally, the damage accumulation in the pins is evaluated, confirming their superior low‐cycle fatigue capacity under earthquake sequences.
Upgraded closed‐form soil hydraulic functions from oven dryness to saturation
Authors: Wang Xixi 
Published: March 2023

AbstractIn the past decades, remarkable progresses have been made in developing soil water retention (SWR) functions and relative hydraulic conductivity (kr) models for the full range of matric suction. However, such an existing SWR function and the corresponding kr model were found not to have a consistent prediction performance, that is, for a given soil, the SWR function could perform very well but the kr model might perform poorly or even fail. Given that both water retention and hydraulic conductivity need to be accurately predicted to simulate land‐atmosphere interactions, vadose‐zone soil–water dynamics, and shallow groundwater recharges, this paper proposed an upgraded SWR function and derived a new closed‐form kr model by combining the function with the well‐known Mualem model. The upgradation was done by introducing an exponential function for the pendular (i.e., dry and very dry) range of matric suction. The SWR function and kr model keep the conventional simplicity, reflect the capillary versus adsorptive soil–water mechanisms, eliminate fictitious parameters, and are continuously differentiable with closed forms. The assessment using the experimental data for 35 soils with nine different textures indicated that the upgraded SWR function and new kr model reproduced the data more accurately than the existing functions and models, as measured by visualization plots and four statistics, namely coefficient of determination, sum squared error, root mean squared error, and Nash–Sutcliffe efficiency. The contribution of this paper is to overcome the inconsistent‐performance issue mentioned above.
Advances in intravital imaging of liver immunity using optical microscopy and labeling methods
Authors: Yuan Xuenan , Yu Xiang , Dai Bolei , Zhang Zhihong 
Published: March 2023

AbstractThe use of optical microscopy and labeling methods in intravital imaging allows for direct tracking of cell behavior and dynamic changes at the molecular level in the physiological or pathological microenvironment of living animals, revealing the spatiotemporal information of individual cells in the immune response. The liver is an immunological organ that contains unique innate and adaptive immune cells, including Kupffer cells (KCs) and different types of T cells, and is involved in coordinating multiple immune responses in the body. Using intravital imaging to visualize the movement behaviors and functions of immune cells during the reaction processes of the liver under physiological and pathological conditions has shed new light on the understanding of liver immunity, which is of great significance for the diagnosis and treatment of liver diseases. This review introduces various window models and labeling methods for the liver in intravital optical imaging and describes how it provides movement behavior and functional information about different types of immune cells, such as KCs and T cells, in the liver. Additionally, we highlight recent advances in intravital optical imaging of liver diseases, such as nonalcoholic fatty liver disease, infections, and tumors. This review aims to be a useful resource for comprehending the developments and achievements in intravital imaging of the liver and uncovering spatiotemporal information of immune response in a living microenvironment.