bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identifying priority questions regarding rapid systematic reviews’ methods: protocol for an eDelphi study
Authors: Vieira Ariany M , Szczepanik Geneviève , de Waure Chiara , Tricco Andrea C , Oliver Sandy , Stojanovic Jovana , Ribeiro Paula A B , Pollock Danielle , Akl Elie A , Lavis John , Kuchenmuller Tanja , Bragge Peter , Langer Laurenz , Bacon Simon 
Published: July 2023

IntroductionRapid systematic reviews (RRs) have the potential to provide timely information to decision-makers, thus directly impacting healthcare. However, consensus regarding the most efficient approaches to performing RRs and the presence of several unaddressed methodological issues pose challenges. With such a large potential research agenda for RRs, it is unclear what should be prioritised.ObjectiveTo elicit a consensus from RR experts and interested parties on what are the most important methodological questions (from the generation of the question to the writing of the report) for the field to address in order to guide the effective and efficient development of RRs.Methods and analysisAn eDelphi study will be conducted. Researchers with experience in evidence synthesis and other interested parties (eg, knowledge users, patients, community members, policymaker, industry, journal editors and healthcare providers) will be invited to participate. The following steps will be taken: (1) a core group of experts in evidence synthesis will generate the first list of items based on the available literature; (2) using LimeSurvey, participants will be invited to rate and rank the importance of suggested RR methodological questions. Questions with open format responses will allow for modifications to the wording of items or the addition of new items; (3) three survey rounds will be performed asking participants to re-rate items, with items deemed of low importance being removed at each round; (4) a list of items will be generated with items believed to be of high importance by ≥75% of participants being included and (5) this list will be discussed at an online consensus meeting that will generate a summary document containing the final priority list. Data analysis will be performed using raw numbers, means and frequencies.Ethics and disseminationThis study was approved by the Concordia University Human Research Ethics Committee (#30015229). Both traditional, for example, scientific conference presentations and publication in scientific journals, and non-traditional, for example, lay summaries and infographics, knowledge translation products will be created.
Update of epidemiology, survival and initial treatment in patients with gastrointestinal stromal tumour in the USA: a retrospective study based on SEER database
Authors: Zhu Haizhen , Yang Guangrong , Ma Ying , Huo Qianwen , Wan Deli , Yang Qiao 
Published: July 2023

ObjectivesAn updated epidemiological analysis of gastrointestinal stromal tumour (GIST), the change of cancer-specific survival (CSS) and patterns of initial treatment are of interest.DesignA retrospective study using data from the Surveillance, Epidemiology and End Results (SEER) database.Setting and participantsA total of 5625 patients with GIST diagnosed between 2010 and 2019 were identified.Primary outcome measuresAge-standardised incidence rate (ASIR) and annual prevalence rate were calculated. SEER combined stage, period CSS rate and initial treatment were summarised. All the data were calculated by SEER*Stat software.ResultsFrom 2010 to 2019, the ASIR of GIST increased from 0.79 to 1.02 per 100 000 person-years, with an increase of 2.4% annually. The increase was across age and sex subgroups. The prevalence trend was similar with the ASIR trend in each subgroup. The stage distributions were similar between different age groups, but varied among different primary tumour sites. More importantly, a stage shift from regional stage to localized stage at diagnosis was found, which may result in the improvement of CSS over years. Overall, the 5-year CSS rate of GIST was approximately 81.3%. Even for metastatic GIST, the rate exceeded 50%. Surgery was the most common treatment regimen for GIST, followed by surgery and systemic treatment. Whereas approximately 7.0% patients were undertreated, which was more pronounced among patients with distant and unknown stages.ConclusionsThe findings of this study suggest an improving early detection of GIST and an improving ability of accurate staging. Though most patients are effectively treated and perform good survivals, approximate 7.0% patients may be undertreated.
Neqstent coil-assisted flow diverter (NQS) for the treatment of bifurcation aneurysms: the coil-assisted flow diversion safety and performance study (CAFI)
Authors: Liebig Thomas , Gal Gyula , O′Kelly Cian , Wodarg Fritz , Killer-Oberpfalzer Monika , Ozpeynirci Yigit , Bester Maxim , Tsogkas Ioannis , Psychogios Marios-Nikos , Jansen Olav , Fiehler Jens 
Published: July 2023

BackgroundThe Neqstent coil-assisted flow diverter (NQS) is a neck bridging device to facilitate coil occlusion of intracranial aneurysms. CAFI is a prospective, single-arm, multicenter study on the safety and performance of the NQS adjunctive therapy device together with platinum coils for treatment of unruptured intracranial aneurysms.MethodsThirty-eight patients were enrolled. Primary endpoints were occlusion at 6 months for efficacy, and any major stroke or non-accidental death up to 30 days or major disabling stroke within 6 months for safety. Secondary endpoints were re-treatment rate, procedure time, and procedure/device-related adverse events. Procedural and follow-up imaging was reviewed by an independent core laboratory. Adverse events were reviewed and adjudicated by a clinical events committee.ResultsThe NQS was successfully implanted in 36/38 aneurysms, 2/38 in the intention-to-treat group did not receive a NQS and were excluded from follow-up after 30 days. In the per protocol group (PP), 33/36 patients were available for angiographic follow-up. Device related adverse events were recorded in 4/38 (10.5%) patients, one hemorrhagic and three thromboembolic. In the PP group, immediate post-treatment adequate occlusion (RR1 and RR2) was seen in 9/36 (25%) and progressed to 28/36 (77.8%) at 6 months. Complete occlusion (RR1) was achieved in 29/36 (80.6%) at the last available angiogram (3/36 were post procedure). The mean procedure time was 129 min (50–300 min, median 120 min).ConclusionThe NQS in conjunction with coils appears to be effective in the treatment of intracranial wide-neck bifurcation aneurysms, but its safety remains to be proved in larger series.Trial registration numberNCT04187573.
Distribution of atrial cardiomyopathy markers and association with atrial fibrillation detected after ischaemic stroke in the SAFAS study
Authors: Didier Romain , Garnier Lucie , Duloquin Gauthier , Meloux Alexandre , Sagnard Audrey , Graber Mathilde , Dogon Geoffrey , Benali Karim , Pommier Thibaut , Laurent Gabriel , Vergely Catherine , Bejot Yannick , Guenancia Charles 
Published: July 2023

BackgroundAtrial cardiomyopathy (AC) is an emerging concept explaining the pathophysiology of cardioembolic strokes in absence of atrial fibrillation (AF). A definition based on the presence of electrical abnormality (P-wave terminal force in lead V1 (PTFV1) >5000 µV×ms), N-Terminal pro-B-type natriuretic peptide (NT pro BNP) >250 pg/mL and/or indexed left atrial diameter (LADI) >3 cm/m² is currently tested in the ARCADIA (AtRial Cardiopathy and Antithrombotic Drugs In prevention After cryptogenic stroke) trial. We set out to estimate the prevalence of AC as defined in the ARCADIA trial, its determinants and its association with AF detected after stroke (AFDAS).MethodsStepwise screening for silent Atrial Fibrillation After Stroke (SAFAS) study prospectively included 240 ischaemic stroke patients. AC markers were complete for 192 of them and 9 were not included in this analysis because AF had been diagnosed on admission.ResultsA total of 183 patients were analysed, of whom 57% (104 patients) met the AC criteria (79 NT-proBNP, 47 PTFV1, 4 LADI). In the multivariate logistic regression, C reactive protein >3 mg/L (OR (95% CI) 2.60 (1.30 to 5.21), p=0.007) and age (OR (95% CI) 1.07 (1.04 to 1.10), p<0.001) were found to be independently associated with AC. After 6 months of follow-up, AFDAS was detected in 33% of AC patients and in 14% of the remaining ones (p=0.003). However, AC was not independently associated with AFDAS, contrary to left atrial volume index (>34 mL/m2, OR 2.35 (CI 1.09 to 5.06) p=0029).ConclusionAC as defined in ARCADIA is mostly based on NT pro BNP elevation (76% of patients) and is associated with age and inflammation. Moreover, AC was not independently associated with AFDAS at follow-up. The ARCADIA trial, which compares aspirin to apixaban in patients with embolic strokes of undetermined source with AC markers and must, therefore be analysed in the light of these limitations.Trial registration numberNCT03570060.
RESENHA DE PIETER BRUEGEL: LE TABLEAU OU LA SPHÈRE – POUR UNE REFORME THÉOLOGICO-POLITIQUE DE L'ENTENDEMENT
Authors: Bianchi Bernardo 
Published: July 2023

Trata-se aqui da resenha do livro Pieter Bruegel: le tableau ou la sphère infinie – pour une reforme théologico-politique de l’entendement, de Laurent Bove, publicado em 2019. O livro explorando, de um ponto de vista espinosista, o tema da “segunda natureza”, o qual, anunciado en passant em La stratégie du conatus: affirmation et résistance chez Spinoza, de 1996, ganhou centralidade em suas monografias publicadas na última década: Vauvenargues ou le séditieux, de 2010, e Albert Camus, de la transfiguration, de 2014. A leitura de Bove busca reconstituir o significado da obra de Pieter Bruegel, o Velho (1525/1530-1569), pintor flamengo cujo legado pertence à Bélgica e aos Países Baixos, a partir de três eixos fundamentais: histórico, artístico e filosófico. A partir de uma problematização da imagem da "esfera infinita", tal como empregada na obra de Nicolau de Cusa, Bove confere um lugar para a pintura de Bruegel enquanto arte filosófica.
Implementation of Rapid Genome Sequencing for Critically Ill Infants With Complex Congenital Heart Disease
Authors: Hays Thomas , Hernan Rebecca , Disco Michele , Griffin Emily L. , Goldshtrom Nimrod , Vargas Diana , Krishnamurthy Ganga , Bomback Miles , Rehman Atteeq U. , Wilson Amanda T. , Guha Saurav , Phadke Shruti , Okur Volkan , Robinson Dino , Felice Vanessa , Abhyankar Avinash , Jobanputra Vaidehi , Chung Wendy K. 
Published: July 2023

BACKGROUND:
Rapid genome sequencing (rGS) has been shown to improve care of critically ill infants. Congenital heart disease (CHD) is a leading cause of infant mortality and is often caused by genetic disorders, yet the utility of rGS has not been prospectively studied in this population.

METHODS:
We conducted a prospective evaluation of rGS to improve the care of infants with complex CHD in our cardiac neonatal intensive care unit.

RESULTS:
In a cohort of 48 infants with complex CHD, rGS diagnosed 14 genetic disorders in 13 (27%) individuals and led to changes in clinical management in 8 (62%) cases with diagnostic results. These included 2 cases in whom genetic diagnoses helped avert intensive, futile interventions before cardiac neonatal intensive care unit discharge, and 3 cases in whom eye disease was diagnosed and treated in early childhood.

CONCLUSIONS:
Our study provides the first prospective evaluation of rGS for infants with complex CHD to our knowledge. We found that rGS diagnosed genetic disorders in 27% of cases and led to changes in management in 62% of cases with diagnostic results. Our model of care depended on coordination between neonatologists, cardiologists, surgeons, geneticists, and genetic counselors. These findings highlight the important role of rGS in CHD and demonstrate the need for expanded study of how to implement this resource to a broader population of infants with CHD.
Coronary Reactivity Assessment Is Associated With Lower Health Care–Associated Costs in Patients Presenting With Angina and Nonobstructive Coronary Artery Disease
Authors: Ahmad Ali , Corban Michel T. , Moriarty James P. , Kanaji Yoshihisa , Rosedahl Jordan K. , Gulati Rajiv , Rihal Charanjit S. , Prasad Abhiram , Sara Jaskanwal D. , Toya Takumi , ter Horst Iris , Lerman Lilach O. , Borah Bijan , Lerman Amir 
Published: July 2023

BACKGROUND:
The financial burden linked to the diagnosis and treatment of patients with chest pain on the health care system is considerable. Angina and nonobstructive coronary artery disease (ANOCA) is common, associated with adverse cardiovascular events, and may lead to repeat testing or hospitalizations. Diagnostic certainty can be achieved in patients with ANOCA using coronary reactivity testing (CRT); however, its financial effect on the patient has not been studied. Our goal was to assess the effect of CRT on health care–related cost in patients with ANOCA.

METHODS:
Patients with ANOCA who underwent diagnostic coronary angiography (CAG) and CRT (CRT group) were matched to controls who had similar presentation but only underwent a CAG without CRT (CAG group). Standardized inflation-adjusted costs were collected and compared between the 2 groups on an annual basis for 2 years post the index date (CRT or CAG).

RESULTS:

Two hundred seven CRT and 207 CAG patients were included in the study with an average age of 52.3±11.5 years and 76% females. The total cost was significantly higher in the CAG group as compared with the CRT group ($37 804 [$26 933–$48 674] versus $13 679 [$9447–$17 910];
P
<0.001). When costs are itemized and divided based on the Berenson-Eggers Type of Service categorization, the largest cost difference occurred in imaging (any type, including CAG;
P
<0.001), procedures (eg, percutaneous coronary intervention/coronary artery bypass grafting/thrombectomy) (
P
=0.001), and test (eg, blood tests, EKG;
P
<0.001).

CONCLUSIONS:
In this retrospective observational study, assessment of CRT in patients with ANOCA was associated with significantly reduced annual total costs and health care utilization. Therefore, the study may support the integration of CRT into clinical practice.
Morphological Changes of Anomalous Coronary Arteries From the Aorta During the Cardiac Cycle Assessed by IVUS in Resting Conditions
Authors: Formato Giovanni Maria , Agnifili Mauro Luca , Arzuffi Luca , Rosato Antonio , Ceserani Valentina , Zuniga Olaya Karina Geraldina , Secchi Francesco , Deamici Miriam , Conti Michele , Auricchio Ferdinando , Bedogni Francesco , Frigiola Alessandro , Lo Rito Mauro 
Published: July 2023

BACKGROUND:
Anomalous aortic origin of coronary artery (AAOCA) with intramural segment is associated with risk of sudden cardiac death, probably related to a compressive mechanism exerted by the aorta. However, the intramural compression occurrence and magnitude during the cardiac cycle remain unknown. We hypothesized that (1) in end diastole, the intramural segment is narrower, more elliptic, and has greater resistance than extramural segment; (2) the intramural segment experiences a further compression in systole; and (3) morphometry and its systolic changes vary within different lumen cross-sections of the intramural segment.

METHODS:
Phasic changes of lumen cross-sectional coronary area, roundness (minimum/maximum lumen diameter), and hemodynamic resistance (Poiseuille law for noncircular sections) were derived from intravascular ultrasound pullbacks at rest for the ostial, distal intramural, and extramural segments. Data were obtained for 35 AAOCA (n=23 with intramural tract) after retrospective image-based gating and manual lumen segmentation. Differences between systolic and end-diastolic phases in each section, between sections of the same coronary, and between AAOCA with and without intramural tract were assessed by nonparametric statistical tests.

RESULTS:

In end diastole, both the ostial and distal intramural sections were more elliptical (
P
<0.001) than the reference extramural section and the correspondent sections in AAOCA without intramural segment. In systole, AAOCA with intramural segment showed a flattening at the ostium (−6.76% [10.82%];
P
=0.024) and a flattening (−5.36% [16.56%];
P
=0.011), a narrowing (−4.62% [11.38%];
P
=0.020), and a resistance increase (15.61% [30.07%];
P
=0.012) at the distal intramural section. No-intramural sections did not show morphological changes during the entire cardiac cycle.

CONCLUSIONS:
AAOCA with intramural segment has pathological segment-specific dynamic compression mainly in the systole under resting conditions. Studying AAOCA behavior with intravascular ultrasound during the cardiac cycle may help to evaluate and quantify the severity of the narrowing.
The Effect of Universal Free School Meals on Child BMI
Authors: Davis Will , Kreisman Daniel , Musaddiq Tareena 
Published: July 2023

Abstract
We estimate the effect of universal free school meal access through the Community Eligibility Program (CEP) on child body mass index (BMI). Through the CEP, schools with high percentages of students qualified for free or reduced-priced meals can offer free breakfast and lunch to all students. With administrative data from a large school district in Georgia, we use student-level BMI measures from the FitnessGram to compare within-student outcomes before and after CEP implementation across eligible and non-eligible schools. We find one year of CEP exposure increased expected BMI percentile by about 0.085 standard deviation, equivalent to a nearly 1.88-pound weight increase for a student of average height. We also find that the program led to a small increase in the likelihood of overweight and limited evidence of a small decrease in the likelihood of underweight. We do not find that the program increased student obesity risk. Examining the effects of CEP on child BMI by grade suggests that the overall effect is largely driven by students in middle schools, highlighting potential heterogeneity in the program's impact across grades. The findings of this paper are relevant for researchers and policy makers concerned with the effects of universal free school meals on student health.
Archaeology, Language, and the Question of Sámi Ethnogenesis
Authors: Svestad Asgeir , Olsen Bjørnar 
Published: July 2023

Abstract
Debates over the ethnogenesis of the Sámi and their historical presence in Fennoscandia have long affected scholarly and public discourses. More recently, these debates have been fueled by new propositions launched by Finnish linguists regarding the origin and development of the Sámi language. In this article, we target this corpus of linguistic research and the wide-ranging implications it suggests for the Sámi past. While based on historical and comparative linguistics data, a notable feature of the studies examined is that they also lean heavily on assumptions about the archaeological record in their reasonings. These assumptions, we argue, are, to a large extent, based on very limited or outdated knowledge of archaeological research on the Sámi past, and in particular, that of northern Norway. The article raises critical questions regarding the notions of cultural areas, ancestral homelands, and migrations that abound in these linguistic studies and challenges the a priori primacy assigned to language as the constituent of cultural identity. In conclusion, we outline a Sámi archaeological past that does not concur well with recent linguistic accounts and which, in the end, begs the question of whether this discrepancy can be reconciled and, if so, how this can happen.
Data Assimilation of Range- and Depth-Averaged Sound Speed from Acoustic Tomography Measurements in Fram Strait
Authors: Geyer Florian , Gopalakrishnan Ganesh , Sagen Hanne , Cornuelle Bruce , Challet François , Mazloff Matthew 
Published: July 2023

Abstract
The 2010–12 Acoustic Technology for Observing the Interior of the Arctic Ocean (ACOBAR) experiment provided acoustic tomography data along three 167–301-km-long sections in Fram Strait between Greenland and Spitsbergen. Ocean sound speed data were assimilated into a regional numerical ocean model using the Massachusetts Institute of Technology General Circulation Model–Estimating the Circulation and Climate of the Ocean four-dimensional variational (MITgcm-ECCO 4DVAR) assimilation system. The resulting state estimate matched the assimilated sound speed time series; the root-mean-squared (RMS) error of the sound speed estimate (∼0.4 m s−1) is smaller than the uncertainty of the measurement (∼0.8 m s−1). Data assimilation improved modeled range- and depth-averaged ocean temperatures at the 78°50′N oceanographic mooring section in Fram Strait. The RMS error of the state estimate (0.21°C) is comparable to the uncertainty of the interpolated mooring section (0.23°C). Lack of depth information in the assimilated ocean sound speed measurements caused an increased temperature bias in the upper ocean (0–500 m). The correlations with the mooring section were not improved as short-term variations in the mooring measurements and the ocean state estimate do not always coincide in time. This is likely due to the small-scale eddying and nonlinearity of the ocean circulation in Fram Strait. Furthermore, the horizontal resolution of the state estimate (4.5 km) is eddy permitting, rather than eddy resolving. Thus, the state estimate cannot represent the full ocean dynamics of the region. This study is the first to demonstrate the usefulness of large-scale acoustic measurements for improving ocean state estimates at high latitudes.

Significance Statement
Acoustic tomography measurements allow one to observe ocean temperature in large ocean volumes under the Arctic sea ice by measuring sound speed, which is hard to synoptically observe by other methods. This study has established methods for assimilation of depth- and range-averaged ocean sound speed from an acoustic tomography experiment in Fram Strait. For the first time, a 2-yr time series of ocean sound from acoustic tomography has been assimilated into an ocean state estimate. The results highlight the use of ocean tomography in ice-covered regions to improve state estimates of ocean temperature.
Immersive technologies and consumer behavior: A systematic review of two decades of research
Authors: Ambika Anupama , Shin Hyunju , Jain Varsha 
Published: July 2023

Immersive technologies, including augmented reality (AR), virtual reality (VR), mixed reality (MR), and three-dimensional (3D) views, are digitally expanding consumers’ reality, enabling never-before-seen experiences. As these technologies transform from a quirky novelty into a ubiquitous utility for consumers, we analyze the advances of the past two decades of research that elaborate on the influence of immersive technologies on consumer behavior. While the past reviews in this area have focused on a limited number of immersive technologies or their application in a sole industry, we holistically analyze and compare the influence of AR, VR, MR, and 3D on consumer behavior across various sectors. We adopt an integrated TCM (Theories, Contexts, and Methods)-ADO (Antecedents, Decisions, and Outcomes) framework to systematically review 129 studies from high-quality academic journals. The findings from this analysis present implications for future research, theory, and practice. JEL Classification: M31 Marketing