bluuebunny/crossref_metadata_2025_split huggingface dataset:
MMPC-live: Accessible resources for phenotyping of live mouse models of diabetes and obesity
Authors: Elias Carol F , Qi Nathan 
Published: January 2025

MMPC-live: Accessible resources for phenotyping of live mouse models of diabetes and obesity
Professor Carol F. Elias, from the University of Michigan’s Department of Molecular & Integrative Physiology, discusses key research opportunities enabled by the NIDDK Mouse Metabolic Phenotyping Center in live models – MMPC-Live. The research community increasingly confronts challenges in accessing, applying, and executing specialized techniques to evaluate nuanced quantitative and qualitative phenotypes in the growing array of genetically altered (e.g., transgenic, knockout), surgically modified (e.g., bariatric surgery), and environmentally influenced (e.g., high-fat diet) mouse models. The expertise, equipment, and capabilities required to perform intricate physiological, metabolic, and behavioral assessments in live mice are often unavailable at every research institution involved in diabetes and obesity studies. In 2001, the National Institute of Diabetes and Digestive and Kidney Diseases (NIH-NIDDK) established the Mouse Metabolic Phenotyping Centers (MMPCs) to provide the scientific community with subsidized, high-quality, specialized phenotyping services. As of 2023, these centers exclusively offer services for live mouse models of obesity, diabetes, and related complications and have been rebranded as MMPC-Live.
Supply chain waste in the pharma industry
Authors: McGuire Jim , McElhone Deborah 
Published: January 2025

Supply chain waste in the pharma industry
The pharmaceutical industry faces significant challenges with supply chain waste, affecting both environmental sustainability and economic efficiency. Jim McGuire and Deborah McElhone from CPI navigate the complex issue here. Supply chain waste refers to inefficiencies that occur throughout the process of producing and delivering medications, which manifests in various forms, including:

1. Expired medications: Drugs not used before their expiration date, leading to significant financial losses and environmental impact.

2. Overproduction: Manufacturing more drugs than needed, resulting in excess inventory.

3. Inefficient distribution: Poor logistics and transportation planning cause product delays and damage, leading to waste.

4. Packaging waste: Excessive or non-recyclable packaging materials contribute to environmental pollution.

5. Regulatory compliance: Navigating complex regulations can lead to delays and additional costs, sometimes resulting in wasted resources.
Targeting the most complex flipon of them all in the fight against cancers
Authors: Herbert Alan 
Published: January 2025

Targeting the most complex flipon of them all in the fight against cancers
In this article, Alan Herbert, the Founder, and President of InsideOutBio, guides us through targeting the most complex flipon of them all in the fight against cancers. In many treasure hunt games, the final step is usually the most difficult. By that time, you know where the quest is located. However, there still remains a frustrating set of challenges that appear impossible to overcome. As you find potential solutions, you unmask even more devious deterrents to your success. Similar obstacles exist for the treatment of cancers, where we are, more often than not, shooting at a moving target with many defenses. It is helpful to think back and look at the problem’s origins. Nature started out with nothing but the prebiotic soup built out of thunder and lightning, a toxic mix of chemicals that none of our modern selves would survive. From simple building blocks, Nature tinkered and evolved the complexity of what we see today. While we admire the exquisite specificity of the molecular toolbox that is now encoded in our DNA, finding magic bullets to target those proteins that cause cancers has proven challenging. This failure is not the fault of the drug-maker, but rather reflects that the targets have closely related family members.
Is civic engagement a potential path to decolonizing education?
Authors: Balzer Geraldine 
Published: January 2025

Is civic engagement a potential path to decolonizing education?
Is civic engagement a potential path to decolonizing education? Here, Geraldine Balzer from the University of Saskatchewan provides an intriguing response. Educators at all levels find themselves enmeshed in systemic structures of power, which significantly impact their ability to build relationships within the community. Colonization and its concurrent political and economic structures laid the foundations for many of the systemic structures, creating inequities that are evident globally. As societies grapple with the resulting inequities actualized, for example, through racism, sexism, and classism, the economic disparities are increasingly apparent.
Role of extracellular electron transfer in the nitrogen cycle
Authors: Bose Arpita , Zhang Zhecheng 
Published: January 2025

Role of extracellular electron transfer in the nitrogen cycle
Extracellular electron transfer impacts the nitrogen cycle by enhancing microbial processes and connecting to other biogeochemical cycles. Understanding EET mechanisms provides insights into ecosystem functioning and potential advancements; Arpita Bose and Zhecheng (Robert) Zhang explain. Nitrogen is a fundamental element required by all living species. It can be found in amino acids, proteins, and nucleic acids. The nitrogen cycle promotes nitrogen transformation and transit across the environment, making it available for biological activity. Key steps in the cycle include nitrogen fixation (conversion of atmospheric nitrogen to ammonia), nitrification (oxidation of ammonia to nitrate), denitrification (reduction of nitrate to nitrogen gas), and anaerobic ammonium oxidation (anammox), which then converts ammonium and nitrite directly to nitrogen gas. Extracellular electron transfer (EET) is the mechanism by which microorganisms transmit electrons from their cells to accept electrons from external donors. This ability allows microorganisms to interact with insoluble substrates, which, in turn, influences a variety of biogeochemical cycles, including the nitrogen cycle. Understanding EET’s function sheds light on microbial ecology and environmental processes.
The impact of bible use on human flourishing among U.S. Military members
Authors: Jang Sung Joon , Johnson Byron R 
Published: January 2025

The impact of bible use on human flourishing among U.S. Military members
The impact of Bible use on human flourishing among U.S. military members is detailed by Sung Joon Jang and Byron R. Johnson from Baylor University and Pepperdine University. It has been long recognized that military members, active and retired, and their families often face various challenges associated with military service, particularly, frequent deployment and combat experience. Despite this recognition, evidence-based and cost-effective interventions that can help them meet these challenges tend to be lacking. Religion and spirituality may be worth more attention for this understudied population of individuals with unique needs largely unrecognized by those outside the military community.
Human history: Handshaking horrors explained
Authors: Corfield Penelope J 
Published: January 2025

Human history: Handshaking horrors explained
Penelope J. Corfield, from Royal Holloway, University of London, offers an intriguing examination of the perils of shaking hands in human history. Shaking hands sends a message of optimism. Strangers can meet and greet on a footing of trust and friendliness. The gesture links two people who need not be equals in worldly status or wealth. But they act as social equals at the moment of mutual salutation. They are using a known social signal within a shared community. How, then, can things go wrong? The answer is that humans, being humans, can always vary and, at times, abuse the salutation. Horrors do happen. Such possibilities do not, of course, mean that people should not be ready to deal fairly with their fellow humans. Nonetheless, the fact that greetings can send varied messages does mean that people should remain vigilant. Not every smiling stranger is automatically a friend. Some may be actually indifferent. Others, at times, are outright deceivers.
Filicide: The search for explanations
Authors: Brown Thea 
Published: January 2025

Filicide: The search for explanations
Thea Brown, Professor Emeritus in the Department of Social Work at Monash University, examines the development of research aimed at understanding filicide. The search for explanations for filicide (the killing of a child or children by a parent, stepparent, or equivalent guardian) has long driven research on filicide - from the time of the earliest studies some sixty years ago (Resnick, 1969) to the present day. Only now, as studies have become more sophisticated, are explanations becoming more reliable. At the same time, they have become more complex and confusing, and the search continues for clear causes as explanations and a basis for prevention.
Computational psychiatry and the opioid crisis: A deep dive
Authors: Bo Cao Cloud 
Published: January 2025

Computational psychiatry and the opioid crisis: A deep dive
In this interview, we speak with Dr. Bo Cao, a leading expert in computational psychiatry at the University of Alberta, Canada. Dr. Cao discusses how advanced data analysis and machine learning are transforming our approach to the opioid crisis and mental health care, offering new hope in addressing one of North America’s most pressing public health challenges. Computational psychiatry takes a revolutionary approach to personalized medicine and understanding mental health by harnessing the power of data analysis and machine learning. Unlike traditional methods that rely primarily on subjective judgment, group-level differences, and the limited scope of handling complex data, computational psychiatry analyzes vast amounts of both objective and subjective health information to uncover hidden patterns and relationships that the human eye might miss and make future predictions on new individual cases.
Modern architecture: A house deconstructed
Authors: Jarzombek Mark , Prakash Vikramaditya 
Published: January 2025

Modern architecture: A house deconstructed
Mark Jarzombek and Vikramaditya Prakash, Co-Founders of the Office of (Un)Certainty Research (a collaboration dedicated to rethinking modern architecture), take us on a journey of a deconstructed house. Professor Vikramaditya Prakash of the University of Washington and Professor Mark Jarzombek of MIT are co-founders of the Office of Uncertainty Research. This collaboration is dedicated to rethinking architecture in a modern context. The office investigates different aspects of architectural production at the planetary scale. They recently studied a just-completed, modern house in Seattle, asking a simple question: Where do all the materials come from? As it turns out, the building industries, even some of those associated with sustainability, make it difficult to trace the origin and flow of materials. Some of this is because materials like rubber are obviously involved in a complex array of processes, many of which are proprietary in nature. Some of it is simply because there are no publicly available records, whether purposefully or not.
Understanding high-temperature material properties
Authors: Volpp Jörg 
Published: January 2025

Understanding high-temperature material properties
Prof Dr-Ing. Jörg Volpp, Associate Professor from University West, Trollhättan, Sweden, states that understanding metal surface tension at high temperatures will increase process understanding to benefit European Union metal processing and manufacturing industries. Many thermal manufacturing methods require heating the materials to high temperatures. Those processes are essential to produce metal parts and components for our modern society. The process outcomes depend on the material properties of the metals, e.g., in casting, welding, brazing, cutting, or Additive Manufacturing (AM). Although those manufacturing methods are used, their complexity often requires extensive process control and material testing to ensure quality. The fluid dynamic effects of overheated molten metals can affect the material properties after solidification, defect formation, and geometrical precision of the parts.
The national animal nutrition program: Digital – editable – perennial – accessible
Authors: Miller Phillip S 
Published: January 2025

The national animal nutrition program: Digital – editable – perennial – accessible
The National Animal Nutrition Program (NANP) aims to enhance animal nutrition and feeding management while actively addressing concerns shared by livestock producers, environmentalists, and policymakers both nationally and globally. Here, they share insights about their work. The National Animal Nutrition Program (NANP) was initially developed as a National Research Support Program-9 (NRSP-9) in 2010 through funding support from agInnovation, the State Agricultural Experiment Stations, the Natural Resource Conservation Service, and Hatch Funds provided by the National Institute of Food and Agriculture, U.S. Department of Agriculture. The NANP provides research-based data on animal nutrient needs, feed ingredients, feeding strategies, and animal performance, as well as software training tools and educational materials to support research.
Purposive physics
Authors: Jeynes Chris , Parker Michael C 
Published: January 2025

Purposive physics
“The Universe doesn’t care about us. It can’t since it has no purpose!” This is what we are told. But is it true? How would we know either way? Concentrating on the physics (never mind the philosophy), the idea of aimlessness arises because the ‘fundamental equations’ (of Quantum Mechanics QM, and General Relativity GR) are reversible in time. Obviously, you can’t have purpose if you can’t distinguish the future from the past.
CRISPR/ Diagnostics: A portable lab for everyone
Authors: Zwezdaryk Kevin J , Monk Chandler H 
Published: January 2025

CRISPR/ Diagnostics: A portable lab for everyone
Professor Kevin J. Zwezdaryk and Chandler H. Monk discuss CRISPR and diagnostics, focusing on the development of a portable lab accessible to everyone. The COVID pandemic highlighted the importance of simple, safe, easy-to-use, and reliable diagnostic platforms. Family members of all ages used a simple sample collection method to provide an easily understandable result – whether they had or did not have COVID. At-home antigen detection tests positively altered public health measures on how individuals and families approached infectious disease diagnosis and surveillance. So why have at-home detection devices not become common tools in our homes?
Political normativity: Exemplarity, plurality, judgment
Authors: Poole Nicholas 
Published: January 2025

Political normativity: Exemplarity, plurality, judgment
Nicholas Poole is a PhD candidate at York University in the Program for Social and Political Thought. Here, he examines political normativity, focusing on the concepts of exemplarity, plurality, and judgment. There are many sources of norms in our world. That we ought derive 4 from the addition of 2 and 2 is distinct from the ‘ought’ implied in our choices not to lie or steal, for instance. But while we may comfortably distinguish epistemic normativity (concerning knowledge) from moral normativity (concerning action), the question of whether politics similarly constitutes its own normative domain has occupied political philosophers for some time.
Studying visitors to museums and other learning spaces
Authors: Heimlich Joe E 
Published: January 2025

Studying visitors to museums and other learning spaces
Joe E. Heimlich, Ph.D., Sr. Director of Research at COSI and Academy Professor Emeritus at Ohio State University, focuses on studying visitors in museums and other informal and nonformal learning environments. What do we know about visitors to museums? While people have been studying visitors to museums for well over 100 years, the field of visitor studies and the more critical study of learning and engaging in informal and nonformal education really have emerged over the last 40 years. As a young academic in the 1980s, I stumbled into working in environmental settings and studying visitors to those places. Over the years, I have studied visitors across all types of museums and non-school learning spaces, and yet when asked, “What do we know about visitors to museums?” I struggle to get a simple reply.
Spotting peripapillary intra-choroidal cavitation using OCT
Authors: Ehongo Adèle 
Published: January 2025

Spotting peripapillary intra-choroidal cavitation using OCT
Adèle Ehongo explores the potential of optical coherence tomography for diagnosing peripapillary intra-choroidal cavitation in myopic eyes. Highly myopic complications, including Peripapillary Intra-Choroidal Cavitation (PICC), underspin the burden of myopia, a condition expected to affect almost half of the global population by 2050. (1) PICC is a circumscribed, yellow-orange lesion located at the outer border of the myopic conus (2) (the crescent-shaped atrophic area at the border of the optic nerve head (ONH)) (Figure 1). It may suggest a choroidal tumor, leading to unnecessary and anxiety-provoking assessments. (2) In up to 73.3% of cases, it is linked to visual field defects suggesting glaucoma, (3) especially since the yellow-orange appearance is absent in up to 53% of PICCs detected by Optical Coherence Tomography (OCT).(4)
Membrane biogenesis, nutrient transport, and natural health product characterization
Authors: Bakovic Marica 
Published: January 2025

Membrane biogenesis, nutrient transport, and natural health product characterization
Find out here about Dr. Bakovic, an internationally recognized researcher in membrane biogenesis, nutrient transport, and natural health product characterization. I, Dr. Bakovic, am an internationally recognized researcher in membrane biogenesis, nutrient transport, and natural health product characterization. My laboratory was the first to clone and elucidate the mammalian Pcyt2 gene and protein structure and function. This is an unexplored research area, and my group was uniquely positioned to initiate the first studies on the regulation and function of this key enzyme for membrane lipid phosphatidylethanolamine (PE) synthesis. Most of the current knowledge about PE metabolism has resulted from my group’s fundamental research. They established how Pcyt2 activity and expression are regulated, which capitalized on identifying the first Pcyt2 inhibitors, meclizine and CHY-1.
Ciliary biomarkers for vascular health
Authors: Ramchandran Ramani 
Published: January 2025

Ciliary biomarkers for vascular health
Ramani Ramchandran, Professor at the Medical College of Wisconsin, investigates ciliary biomarkers for diagnosing and prognosing vascular health. Vessels carry blood and biomarkers, which are substances in blood that inform the underlying status of vascular health in people. To date, most biomarkers in the blood are associated with proteins, lipids, sugars, and nucleic acids. Cellular organelles are rarely considered as biomarkers. Our work on a tiny hair-like organelle called cilia found in most cells and the proteins inside them as potential biomarkers that inform underlying vascular health (1) is one of the first studies to consider this concept.
A legacy of medicine and biodiversity: Protecting the cinchona tree
Authors: Cueva-Agila Augusta , Armijos-González Rosa 
Published: January 2025

A legacy of medicine and biodiversity: Protecting the cinchona tree
The endangered Cinchona officinalis, native to the Andean foothills, produced the world’s first anti-malarial drug. Augusta Cueva-Agila explains why it is crucial to conserve this species and how conservation efforts can be implemented. The cinchona tree (Cinchona officinalis, L.), a species endemic to the Andean cloud forests of Ecuador and Peru, is a very special tree in the history of humanity. This species is the source of quinine, a breakthrough medicine against malaria that saved the lives of hundreds of people, making it one of the most important plants in history. However, centuries of over-harvesting, followed by deforestation and the advance of agricultural frontiers, have pushed this species to the brink of extinction. Its conservation is a challenge and a priority for biodiversity conservation.
Teen relevant and open access health information for building vaccine confidence
Authors: Cook Karen , Blomgren Constance , George Stella 
Published: January 2025

Teen relevant and open access health information for building vaccine confidence
With the abundance of health information about vaccines online, there is a need for an open educational resource (OER) that empowers youth to understand the importance of vaccines and make informed medical choices. In today’s digital age, where online information is abundant and conflicting, young people are challenged to find evidence-based and developmentally appropriate information to make decisions about vaccinations. Their decisions will impact not only themselves but also the next generation. Once beliefs are instilled, they are difficult to challenge and change.
Communicating science: The “significance” of statistics
Authors: Miller Jane E 
Published: January 2025

Communicating science: The “significance” of statistics
Statistical significance and scientific importance are distinct, equally valuable aspects of communicating the significance of statistics in scientific research. Communicating the “significance” of statistics in scientific research is often plagued by the fact that the everyday usage of “significant” is very different than the technical meaning of that term. When most people read “significant,” they interpret it to mean “big” or “important.” When statisticians say “significant,” they intend it to mean that the estimated effect size is unlikely to have arisen by chance. Although both aspects of “significance” are key parts of communicating scientific research, those definitions clearly are not interchangeable! Unfortunately, this confusion between statistical significance and scientific importance has been so widespread (even among scientists!) that statisticians have been making recommendations for years on ways to differentiate between them when communicating scientific results (Amrhein et al., 2019; McShane et al., 2019). Despite those efforts, the two usages continue to be conflated by scientists and laypeople alike.
Living with rare genetic disorders: Challenges of EPP and XLP
Authors: Belongie Kirstine Juhl 
Published: January 2025

Living with rare genetic disorders: Challenges of EPP and XLP
Kirstine Juhl Belongie discusses the impact, symptoms, and possible treatments related to EPP and XLP, two debilitating disorders that cause extreme pain following exposure to sunlight. For most people, a warm sunny day feels comfortable on the skin, but sun rays can produce excruciating pain for a rare group of people born with a genetic mutation in two specific genes. Photosensitivity or even phototoxicity occurs for many reasons (genetic, drug-induced, or allergic reaction from an unknown cause) and can be expressed as rashes, blistering, redness, or pain.