bluuebunny/crossref_metadata_2025_split huggingface dataset:
Система підготовки вчительських кадрів для церковних шкіл в лівобережних українських єпархіях Російської імперії на межі ХІХ – ХХ ст.
Authors: Petrenko Iryna , Vynnychenko Ihor 
Published: January 2023

Мета статті: висвітлити процес організації та підготовки вчительських кадрів для церковних шкіл у лівобережних українських єпархіях Російської імперії на межі ХІХ – ХХ ст. Зокрема, виявити та проаналізувати особливості функціонування церковно-учительських шкіл і курсів підвищення кваліфікації педагогічних кадрів шкіл духовного відомства. З’ясувати специфіку освітянської та культурницько-просвітницької діяльності православного духовенства на зламі ХІХ-ХХ ст.
Наукова новизна: із загальної теми церковної освіти окремим сегментом виділено учительський корпус, що дало змогу розглянути систему підготовки учительських кадрів. Комплексно досліджено специфіку функціонування церковно-учительських шкіл і підвищення кваліфікації у лівобережних українських єпархіях Російської імперії. Простежено механізм комплектування учительського корпусу єпархій, що дало можливість виявити тенденції еволюції складу учительства, розглянуто кадровий склад як окремий складник галузі освіти. Удосконалено та розширено загальну характеристику освітянської активності духовенства.
Висновки. На основі проведеного дослідження зроблено висновок про те, що учительський склад церковнопарафіяльних шкіл, як складник системи початкової освіти, перебував під пильним контролем церковно-шкільної адміністрації єпархій і церковно-управлінських структур. У зазначених географічних рамках лише Полтавська єпархія мала спеціальні два навчальних заклади – церковно-учительські школи (на полі Полтавської битви й у м. Лубни). Харківська губернія була знаним центром церковно-шкільної справи, яка поширювала досвід викладання Закону Божого на інші єпархії. У Чернігівській губернії на належному рівні відбувалося підвищення кваліфікації педагогічних кадрів, оскільки там учительські курси мали свою спеціалізацію: співочу, сільськогосподарську, богословську.
Церковно-вчительське шкільництво на межі ХІХ-ХХ ст. тільки розпочинало свою діяльність, і Перша світова війна та атеїстична радянська пропаганда не дали можливості виявити весь їх потенціал. За своє короткочасне існування церковно-учительські школи не встигли забезпечити належних масштабів підготовки вчителів для шкіл церковного відомства. Значна частина педагогічних кадрів церковних шкіл так і залишилася без фахової педагогічної освіти.
Functions and relevance of spatial co-presence: Lessons learned from the COVID-19 pandemic for evidence-based workplace and human capital management
Authors: Windlinger Lukas , Gerber Marius 
Published: January 2023

Introduction: This study aims to analyze the role of co-presence against the background of COVID-19 pandemic to derive implications for an interdisciplinary, evidence-based workplace and human capital management. A theoretical framework is outlined that considers a range of topics from task performance to social and organizational contextual factors.Methods: In a single organization qualitative case study, five focus group interviews including a total of 20 employees of an IT consultancy were conducted to identify the effects of the mandatory remote working regimes imposed by the COVID-19 Pandemic on task and contextual performance.Results: Findings show that individual performance was assessed to have increased while internal processes remained at similar levels compared to pre-pandemic levels. Organizational culture, social contact, and identity, however, were reported to have considerably deteriorated in the view of the participants.Discussion: The study shows that for a company that was very experienced with distributed working, the reduction of co-presence had important effects on performance and culture. Findings suggest that co-presence must be carefully managed in the future. This could become a new joint priority for workplace design, workplace management, and human capital management.
Combined chemical transformation and biological transformation of artemisinin: A facile approach to diverse artemisinin derivatives
Authors: Gao Xinna , Bai Yue , Sun Peng , Gao Huimin , Yang Lan , Zhang Dong , Zhao Yifan , Ma Yue 
Published: January 2023

Introduction: Artemisinin (1) is a milestone compound in malaria treatment, and it exhibits a broad scope of bioactivities. Herein, sequential chemo-reduction and biotransformation of artemisinin were undertaken to obtain a series of artemisinin derivatives.Methods: First, 10-deoxyartemisinin (2) and 9-ene-10-deoxyartemisinin (3) were synthesized after simple handling with boron trifluoride/diethyl ether and sodium borohydride. Then, biotransformation of 10-deoxyartemisinin was conducted with Cunninghamella echinulata CGMCC 3.4879 and Cunninghamella elegans CGMCC 3.4832, and the transformed products were separated and identified. The antimalarial activity of these products was tested in vitro against Plasmodium falciparum 3D7.Results: Fifteen metabolites (4–18), including seven novel compounds, were isolated and identified after cultivation. Compounds 2, 3, 13, 15, 16, and 18 displayed moderate-to-good antimalarial activity, with a half-maximal inhibitory concentration ranging from 6 to 223 nM.Discussion: This work explored the combination of chemical and biological transformation to develop a co-environmental, efficient, and cost-efficiency synthetic methodology and applied it to synthesize novel derivatives of artemisinin. The association of the two strategies will hopefully provide an abundant source for the development of novel drugs with bioactivities.
Influence of CYP2C19 genetic variants and smoking on dual antiplatelet efficacy in patients with coronary artery disease
Authors: Cheng Yujing , Sun Yan , Zhang Dai , Ma Xiaoteng , Liu Chi , Hu Chengping , Sun Tienan , Zhao Ziwei , Liu Xiaoli , Zhou Yujie 
Published: January 2023

IntroductionThis study aimed to investigate the effects of smoking and CYP2C19 gene polymorphism on antiplatelet therapy to specify the most optimized and accurate antiplatelet therapy for different populations.MethodsThis study included 6,353 patients with coronary artery disease (CAD). In total, 2,256 (35.5%) were smokers and 4,097 (64.5%) were non-smokers. Patients carrying a CYP2C19*2 or *3 allele were considered loss-of-function (LOF) allele carriers. The medical history of patients who had undergone percutaneous coronary intervention (PCI) at Beijing Anzhen Hospital was recorded. The primary endpoint was major adverse cardiovascular or cerebrovascular events (MACCE) during the 6-month follow-up period. A Cox regression model was used to assess the interactions between antiplatelet efficacy and CYP2C19 LOF allele carrier status, stratified by smoking status.ResultsCompared to clopidogrel plus aspirin, ticagrelor plus aspirin reduced the MACCE recurrence risk in non-smokers (carrier: 6.0 vs. 2.0%, hazard ratio 0.298, 95% confidence interval 0.204–0.635, P &lt; 0.0001; non-carrier: 5.8 vs. 2.1%, hazard ratio 0.358, 95% confidence interval 0.189–0.678, P = 0.002), and not in smokers. Similar results were discovered regarding the recurrence rate for hospitalization for ischemic cardiac events in non-smokers. No apparent difference was discovered in the bleeding events in either group. There were no significant associations between antiplatelet medication and CYP2C19 LOF allele carrier status for the MACCE recurrence risk among smokers (P = 0.943, respectively) or non-smokers (P = 0.774, respectively).ConclusionIn patients with CAD after PCI, ticagrelor plus aspirin lowered the MACCE recurrence risk in CYP2C19 LOF allele carriers and non-carriers compared with clopidogrel plus aspirin alone among non-smokers. The efficacy of antiplatelet therapy varies between CYP2C19 LOF allele carrier status. No significant interaction between CYP2C19 LOF allele carrier status and antiplatelet effectiveness was observed. However, caution should be used to interpret our results considering the many limitations of our investigation.
Longer physical exercise duration prevents abnormal fasting plasma glucose occurrences in the third trimester: Findings from a cohort of women with gestational diabetes mellitus in Shanghai
Authors: Zhang Rui , Gao Xiangjin , Sun Ting , Li Huan , Yang Qing , Li Bin , Zhu Dongshan , Wang Ruiping 
Published: January 2023

ObjectiveThis study aims to investigate the relationship between daily physical exercise (PE) duration and frequency of abnormal plasma glucose (PG) times both during fasting and 2 h after a standard diet in women with gestational diabetes mellitus (GDM).MethodsWe established a cohort involving 878 GDM women. GDM was confirmed by a diagnostic 75-g oral glucose tolerance test. Information was extracted from the delivery records and antenatal checkup forms. Physical exercise information was collected through a questionnaire.ResultsOver 80% of GDM women were under 35 years old. An abnormal fasting PG with ≥1 occurrence presented in 742/878 (84.51%), and the abnormal PG 2 h after standard diet with ≥1 occurrence presented in 634/878 (72.21%). Compared to GDM women with ≥4 occurrences of abnormal fasting PG, GDM women with 0 occurrences (odds ratio (OR) = 2.56), one occurrence (OR = 1.94), two occurrences (OR = 2.29), and three occurrences (OR = 2.16) had a higher proportion of PE duration being in the 45–60-min/day group than those in the &lt;45-min/day group, and GDM women also had a higher proportion of PE during being in the 61–90- and &gt;90-min/day group than those in the &lt;45-min/day group. However, the duration of PE was not associated to the number of abnormal PG occurrences 2-h after the standard diet.ConclusionModerate-intensity PE duration in GDM women was negatively associated with the number of abnormal fasting PG occurrences but not with the number of PG occurrences 2 h after the standard diet.
Using a well-to-well interplay during the CO2 huff-n-puff process for enhanced oil recovery in an inclined oil reservoir: Experiments, simulations, and pilot tests
Authors: Hao Hongda , Hou Jirui , Qu Ming , Guo Wenmin , Deng Song , Liu Huaizhu 
Published: January 2023

A well-to-well interplay of CO2 huff-n-puff is proposed as a novel gas injection strategy for displacing interwell-remaining oil in a well pair in an inclined oil reservoir. The well-to-well interplay mechanisms for enhanced oil recovery (EOR) are first studied in the laboratory using a three-dimensional (3D) physical model. Different CO2 injection schemes are designed according to different well locations, and the production performance including oil, water, and gas rates is used for the EOR evaluation. A sensitivity analysis of the well-to-well interplay is then studied using a numerical model, and geological, developmental and fluidic factors are considered in the simulations. The experimental results show that, when CO2 is injected into a lower well, a higher well always benefits with an oil increment. Under the effects of gravity segregation and edge-water driving, the injected CO2 at the lower position can move upward to a higher position, where a large proportion of crude oil remains between wells after natural edge-water flooding. Oil recovery from the well-to-well interplay is 2.30% higher than conventional CO2 huff-n-puff in the laboratory. Numerical results show that CO2 injection mass, stratigraphic dip, horizontal permeability, and interwell spacing are the factors that most influence the well-to-well interplay; an application criterion for the well-to-well interplay is then proposed based on the simulations. Pilot tests using the well-to-well interplay of CO2 huff-n-puff have been widely applied in C2-1 Block, Jidong Oilfield, China, since 2010. A total of 2.27 × 104 m3 crude oil was recovered to the end of 2018, and the oil/CO2 exchange ratio was as high as 3.92. The well-to-well interplay not only effectively extracted the interwell-remaining oil but also achieved higher CO2 utilization efficiency. The findings of this study can lead to a better understanding of the EOR mechanisms used in the well-to-well interplay during the CO2 huff-n-puff process in an inclined oil reservoir.
Incidence and predictors of puerperal sepsis among postpartum women at Debre Markos comprehensive specialized hospital, northwest Ethiopia: A prospective cohort study
Authors: Bishaw Keralem Anteneh , Sharew Yewbmirt , Beka Endihnew , Aynalem Bewket Yeserah , Zeleke Liknaw Bewket , Desta Melaku , Kassie Bekalu , Amha Haile , Eshete Tewodros , Tamir Workineh , Bantigen Kerebih , Mulugeta Henok , Ferede Addisu Andualem , Bitewa Yibelu Bazezew 
Published: January 2023

BackgroundPuerperal sepsis is one of the leading causes of maternal mortality, particularly in low and middle-income countries where most maternal deaths occur. Women with puerperal sepsis are prone to long-term disabilities, such as chronic pelvic pain, blocked fallopian tubes, and secondary infertility. Besides this, puerperal sepsis has received less attention. For this reason, this study aimed to determine the incidence of puerperal sepsis and its predictors among postpartum women at Debre Markos Comprehensive Specialized Hospital.MethodsA prospective cohort study was conducted among 330 postpartum women from September 2020 to 2021. A pre-tested interviewer-administered questionnaire with a data extraction checklist was used to collect the data. Data were entered into Epi data 4.2 and analyzed using STATA 14.0. The incidence rate of puerperal sepsis was calculated, and a Kaplan-Meier survival curve was used to estimate the survival probability of developing puerperal sepsis. The cox-proportional hazards regression model was fitted to identify predictors of puerperal sepsis.ResultsThe study participants were followed for a total of 1685.3 person-week observations. The incidence rate of puerperal sepsis was 14.24 per 1,000 person-weeks. However, the overall incidence of puerperal sepsis was 7.27%. Not attending formal education [AHR: 3.55, 95% CI: (1.09–11.58)], a cesarean delivery [AHR: 4.50; 95% CI: (1.79–11.30)], premature rupture of the membranes [AHR: 3.25; 95% CI: (1.08–9.79)], complicated pregnancy [AHR: 4.80; 95% CI: (1.85–12.43)], being referred [AHR: 2.90; 95% CI: (1.10–7.65)], and not having birth preparedness and complication readiness plan [AHR: 2.95; 95% CI: (1.08–10.50)] were statistically significant predictors of puerperal sepsis.ConclusionThe incidence of puerperal sepsis was 7.27%. Not attending formal education, cesarean delivery, premature rupture of membranes, complicated pregnancy, referral status, and absence of birth preparedness and complication readiness plan were predictors associated with the incidence of puerperal sepsis.
Analysis of living habit risk factors for esophageal cancer in central China: A bi-center case-control study
Authors: Yuan Lingzhi , Shen Peijun , Zheng Shaopeng , Wu Dongwen , Li Xinmeng , Cai Ting , Yao Yao , Song Yunhe , Wang Fen 
Published: January 2023

BackgroundEsophageal cancer remains a public health problem in many countries, especially developing countries. The early lifestyle preventive measures mentioned in the treatment guidelines for esophageal cancer are very limited. We aimed to evaluate the risk factors for esophageal cancer in a high-incidence area in China and to provide evidence for clinical intervention in esophageal cancer prevention.MethodsSymptom and lifestyle/habit questionnaires including 19 items were designed. The correlation between the occurrence of esophageal cancer and living habits was analyzed retrospectively through questionnaire survey. A total of 708 subjects (365 esophageal cancer, 343 non-esophageal cancer) enrolled from two hospitals in central China (Linzhou Esophageal Cancer Hospital and The Third Xiangya Hospital of Central South University) completed symptom and lifestyle/habit questionnaires. We used conditional logistic regression to estimate the odds ratio (OR) with consideration of 95% confidence interval (CI).ResultsThe composition ratio analysis showed that the top five lifestyle factors related to esophageal cancer were eating too fast, drinking, hot drinks, smoking and overeating. Univariate analysis showed that 15 factors, including male sex, smoking, drinking, eating too fast, overeating, hot drinks, greasy food, acidic food, hard food, strong tea, coffee, bedtime immediately after meals, eating food before bedtime, difficult defecation, and an overtight belt, were associated with esophageal cancer (all P &lt;0.05). Logistic multivariate regression analysis showed, drinking (OR 3.609, 95%CI 2.223-5.859; P=0.000); hot drinks (OR 2.672, 95%CI 1.786-3.997; P=0.000); overeating (OR 2.110, 95%CI 1.411-3.154; P=0.000); eating too fast (OR 1.879, 95%CI 1.274-2.772; P=0.001); strong tea (OR 1.882, 95%CI 1.171~3.023; P=0.009); hard food (OR 1.723, 95%CI 1.113-2.667; P=0.015); smoking (OR 1.686, 95%CI 1.045-2.720; P=0.032), which were significantly associated with the development of esophageal cancer.ConclusionThe unhealthy lifestyles of patients in high-incidence areas of esophageal cancer in central China are significantly associated with the incidence of esophageal cancer. Lifestyle changes that address these factors, especially overeating and eating too fast, which are rarely studied or discussed despite being common, may improve esophageal cancer management and treatment outcomes. The present results may be used as a reference for preventive education and treatment.
Advanced intestinal regulation improves bowel preparation quality in patients with constipation: A systematic review and network meta-analysis
Authors: Ding Liang , Duan JinNan , Yang Tao , Jin ChaoQiong , Luo Jun , Ma Ahuo 
Published: January 2023

Background: Inadequate bowel preparation (IBP) has a critical influence on the colonoscopy procedure and is associated with significantly lower rates of detection of colorectal lesions. Constipation is an important risk factor of IBP, and some studies have attempted to address the bowel cleansing for constipated patients. However, there is still lack of consensus to guide the clinical work of bowel preparation (BP) for patients with constipation. Therefore, we aimed to perform a network meta-analysis to compare the overall efficacy of various regimens for BP in constipated patients.Methods: We performed a comprehensive search of PubMed, MEDLINE, EMBASE, Cochrane, and Web of science to identify randomized controlled trials (RCTs) of bowel preparation regimens in constipated patients, update to January 2021. Two investigators independently evaluated articles and extracted data. The odds ratio (OR) with a 95% confidence interval (CI) was used to combine dichotomous data of the primary outcome which was defined as adequate bowel preparation (ABP). Rank probability was used to exhibit the outcome of the network meta-analysis.Results: Eleven studies that included 1891 constipated patients were identified as suitable for inclusion. The proportion of ABP was associated with the administration of intensive regimen (OR 2.19, 95% CI 1.16–4.17, p = .02, I2 = 84%). Moreover, an intensive regimen had a significant efficacy and light heterogeneity when the same basic laxative program was used (OR 4.06, 95% CI 3.04–5.43, p &lt; .0001, I2 = 0%). In the network meta-analysis, the protocol of a normal regimen + A (normal regimen plus advanced intestinal regulation) had a significant effect for bowel preparation compared with a normal regimen + IR (normal regimen plus irritating laxative regimen) (OR 5.21, 95% CI 1.18–24.55), H PEG (4L- polyethylene glycol) (OR 8.70, 95% CI 1.75–52.56), and normal regimen (NR) (OR 7.37, 95% CI 2.33–26.39). In the remaining protocols, no significant difference was observed in any comparison. No significant severe adverse events (AEs) associated with bowel preparation were reported in included studies.Conclusion: Intensive regimens could improve bowel cleansing quality for patients with constipation, and advanced intestinal regulation regimens may be superior to others.
Short-term cold-water immersion does not alter neuromuscular fatigue development during high-intensity intermittent exercise
Authors: Faricier Robin , Haeberlé Olivier , Lemire Marcel 
Published: January 2023

Aims: Pre-exercise cold-water immersion affects physical performance under ambient environment, however the mechanisms leading to this decrease remains to be elucidated. The purpose was to determine whether short-term lower-body immersion in cold water could induce acute changes in the development of neuromuscular fatigue after high-intensity exercise. Methods: Ten participants performed on two separate visits a fatigue task (60 intermittent isometric maximal voluntary contractions maintained over 3 s and spaced by 2 s of recovery) once after lower-body cold-water immersion (Pre-Cooling, 6 min at 8.9°C ± 1.6°C) and another time without prior immersion (Control). Before and after the fatigue task, neuromuscular function was assessed during voluntary or evoked contractions (electrical stimulation performed on the femoral nerve) on contracted and relaxed on knee extensor muscles. Results: No differences in neuromuscular fatigue were measured between Pre-Cooling and Control conditions, despite maximal voluntary contraction reductions (−49 and −48%, respectively, both p &lt; 0.05), peripheral contractile capacities (both -28%, p &lt; 0.05). Additionally, rate of perceived exhaustion increases over time for both conditions (both p &lt; 0.05) with differences in the time course. Discussion: Lower body immersion in extreme cold water for a short period of time was not a sufficient stimulus to induce a significant disruption of human body homeostasis: neuromuscular function was not significantly altered during a maximum intensity fatigue task.
Gait strategies for individuals with knee osteoarthritis when transitioning between floor and stair walking
Authors: Chai Yatai , Chen Jian , Hou Meijin , Zheng Jiaqi , Liu Lu , Chen Yongkang , Fu Shengxing , Ma Ye , Hong Tiansheng , Wang Xiangbin 
Published: January 2023

Objective: Individuals with knee osteoarthritis are at higher risk for falls during transitions between floor and stair walking due to their reduced lower extremity function. However, the adjust gait characteristics of knee osteoarthritis subjects for dealing with stair transitions have not been explored. We aimed to investigate gait strategies in individuals with knee osteoarthritis compared to age-matched individuals without knee OA during the transition between walking on floor and stairs.Method: Gait of 30 individuals with knee osteoarthritis and 30 individuals without knee osteoarthritis during floor-to-stair and stair-to-floor walking transitions were accessed using a 3D motion capture system. Foot-tread clearance, and angles of lower extremity joints and trunk at Foot-tread clearance timepoint were analyzed by using biomechanical software (Visual 3D).Results: Compared with asymptomatic control group, the knee osteoarthritis group demonstrated no difference in vertical Foot-tread clearance and horizontal Foot-tread clearance during stair transitions. However, ankle dorsiflexion (p = 0.01) decreased, hip flexion (p = 0.02) and trunk lateral tilt (p = 0.02) increased in knee osteoarthritis group during the stair ascent transition. Moreover, trunk lateral tilt to the support side (p = 0.003) and pelvic rotation (p = 0.03) increased, while hip abduction of the swing leg (p = 0.03) decreased during the stair descent transition in individuals with knee osteoarthritis.Conclusion: Increased trunk lateral tilt and altered angle of hip may be a strategy utilized by individuals with knee OA to increase the foot clearance ability and compensate for the disease-related loss of lower extremity strength, range of motion, and balance. However, compensatory manifestations, such as the increased lateral tilt of the trunk and movement of the gravity center may enhance the risk of falls and result in more abnormal knee joint loading.