bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Winding Path of Depression in Argentina from Awareness to
Functional Recovery
Authors: Rojtenberg Sergio , Mosca Daniel , Verdaguer Maria Fernanda , Martinez Monica , Elorza Paola M. 
Published: May 2023

Background:
Despite the huge global socioeconomic burden of depressive disorders,
depression is often underreported and undertreated due to a lower level of awareness from
both healthcare providers and payers in many countries. The lack of an evidence-based approach
to care delivery has resulted in the inequitable allocation of health resources, causing
resource scarcity issues in Argentina.

Objective:
The aim of this paper is to identify the gaps in evidence related to patients’ journeys
and barriers in the existing care ecosystem contributing to poor access to quality care for depression
in an Argentine context.

Methods:
A semi-systematic review of the literature was performed from 2012 to 2021 using
Medline, Embase and Biosis and other unstructured sources (Google Scholar, the World Health
Organization (WHO) website, Argentina Ministry of Health website, and Incidence and Prevalence
Database (IPD) on awareness, screening, diagnosis, treatment, adherence and/or control
of depression amongst adults (≥18 years). Any identified data gaps were supplemented with
anecdotal data from local experts.

Results:
Low percentages of adult patients with depression awareness (<25%), screening
(<10%), diagnosis (37.5%), received treatment (41.9%), adherence to treatment (37.5%), and
control (37.5%) were observed.

Conclusion:
Ensuring a care continuum while considering full clinical remission with functional
recovery as a therapeutic goal and advocacy for patient-centric adjustments in existing
mental health policies would be key drivers for improving the depression care scenario.
Acute Moist Dermatitis with Thrombocytopenia in Cat
Authors: Desiandura Kurnia , Hermawan Intan Permatasari , Wardhani Hana Cipka Pramuda , Restijono Era Hari Mudji , . Palestin 
Published: May 2023

Abstract Background: The causes of cases of Acute Moist Dermatitis (AMD) or also known as hotspots are numerous. Early AMD is accompanied by symptoms of pruritus or different behaviors triggered by itching such as scratching or licking. Many causes of pruritus in cats such as hypersensitivity dermatitis, ectoparasites, fungal infections, bacterial infections, or skin reactions to systemic diseases. Gradually clinical symptoms will occur alopecia and erythema because it is very itchy, moist and smells on the surface of the skin. Case Description: A male Persian cat, 1.6 years old and weighing 3.4 kg, presented with a history of pruritus, alopecia, erythema and wet skin in several locations, especially around the neck, and had been present for 3 months. Appetite to eat and drink is not very good because the cat is busy scratching and biting its fur due to excessive itching. Examination Results and Treatments: After clinical examination and microscopic examination of samples, the main trigger in this case was furmite in a cat, Lynxacarus radovskyi with secondary bacterial infection causing Acute Moist Dermatitis (AMD). Not only that, ectoparasites in this case also cause other systemic diseases, namely suspicion of blood parasites that cause thrombocytopenia as evidenced by the results of a Complete Blood Count (CBC), and is characterized by clinical symptoms of hematuria and epistaxis. This cat underwent intensive treatment for several weeks with several combinations of drugs such as antiparasitics, antibiotics. antihistamines, NSID and vitamins. Conclusion: This
Pemanfaatan Ekstrak Daun Kelor (Moringa oleifera lamk) untuk Penyembuhan Luka Tikus Ovariektomi yang Diberi Diet Tinggi Lemak
Authors: Fadillah Sucia , Aji Dhirgo , Anggraeni Devita 
Published: May 2023

Penelitian ini bertujuan untuk mengetahui efektivitas pemberian salep ekstrak etanol daun kelor 20% (EEDK 20%) pada penyembuhan luka berdasarkan gambaran histopatologi yang meliputi jumlah leukosit pada jaringan luka dan ketebalan epitel. Enam belas ekor tikus Sprague-Dawley betina, umur 3-4 bulan dengan berat 150-200 g, dibagi menjadi 4 kelompok perlakuan (A,B,C dan D) secara acak. Seluruh tikus diovariektomi dan diberi perlakuan pakan selama 8 minggu. Kelompok A dan C diberi pakan normal, sedangkan kelompok B dan D diberi pakan tinggi lemak. Setelah 8 minggu, dilakukan pengambilan darah untuk analisis kadar lemak (kolesterol dan trigliserida) dan pembuatan luka di area punggung dengan biopsy punch (8 mm). Perawatan dilakukan dengan pemberian salep selama 7 hari dan injeksi antibiotik. Kelompok A dan B diberi salep basis, sedangkan C dan D diberi salep EEDK 20%. Hari ke-7 dilakukan pengambilan jaringan kulit untuk analisis histopatologi dengan pengecatan Hematoksilin Eosin. Kadar lemak darah (kolesterol dan trigliserida) dianalisis secara statistik dengan one way ANOVA, sedangkan jumlah leukosit di jaringan dan ketebalan epitel dianalisis dengan two way ANOVA. Hasil penelitian menunjukkan bahwa jumlah leukosit di jaringan dipengaruhi oleh jenis salep (P<0.05), sedangkan ketebalan epitel dipengaruhi oleh jenis salep dan pakan (P<0,05). Salep EEDK 20% dapat menurunkan jumlah leukosit di jaringan, meningkatkan ketebalan epitel dan memiliki gambaran histopatologi kulit yang baik. Dapat disimpulkan bahwa pemberian salep EEDK 20% dapat meningkatkan proses penyembuhan luka tikus yang diovariektomi dan diberi pakan tinggi lemak. Kata kunci : daun kelor; luka; penyembuhan; salep EEDK 20%; tinggi lemak
Barriers and facilitators to the uptake of the Concussion Awareness Training Tool as continuing medical education in primary care
Authors: Devji Jalila , Karmali Shazya , Turcotte Kate , Babul Shelina 
Published: May 2023

Aim: Continuing medical education (CME) informs physicians on current research. The Concussion Awareness Training Tool (CATT) provides education on concussion diagnosis and treatment. The aims of this study were to explore physician CME practices and preferences, understand barriers and facilitators to implementing the CATT as CME, and provide recommendations. Materials & methods: Physicians in British Columbia, Canada participated in an online survey and telephone interview. Descriptive analysis of quantitative data, and text-based data analysis were undertaken to identify themes. Results: Barriers included lack of time and awareness of the resource. Facilitators were its ease of use, accessibility, conciseness and comprehensiveness. Conclusion: The perceptions of barriers and facilitators reported by physicians are important to understand and better promote the use of the CATT.
Factors of Organizing Surgical Treatment of Upper Gastrointestinal Cancers and Patient Survival: Real-World Data
Authors: Andreev D. A. , Zavyalov A. A. 
Published: May 2023

Aim: to analyze the safety and effectiveness of the method of cold snaring resection with preliminary hydropreparation when removing superficially colorectal epithelial neoplasms with a diameter of 5 to 25 mm.Material and methods. The number of complications and disease recurrence after endoscopic excisions by “cold” snaring resection with preliminary hydropreparation of superficially neoplasms with a diameter of 5 to 25 mm was assessed.Results. Neoplasms were removed in a single block in 89/122 (72.95 %) cases. Neoplasms with a diameter of 5 to 9 mm were excisions in a single block in 100 % of cases, with a diameter of 9 to 14 mm in 28/30 (93.33 %) cases, with a diameter of 15 to 19 mm in 12/38 (31.57 %) cases. According to the results of a lifetime pathoanatomic examination of the removed material, serrated dysplasia (serrated dysplasia, low grade) was detected in 76 cases; micro vesicular hyperplastic polyps (Hyperplastic polyp, micro vesicular type MVHP) were established in 9 cases; hyperplastic polyps containing goblet cells (Hyperplastic polyp, goblet cell GCHP) were in 5 cases; tubular adenoma with dysplasia (Tubular adenoma, low grade) was in 32 cases. Delayed bleeding and perforation of the intestinal wall, both at the time of resection, and in the delayed period was not observed. No local recurrence was detected in the groups of patients with neoplasms diameters of 5-9 and 10-14 mm. One case of local recurrence was detected in a group of patients with a neoplasms diameter from 15 to 19 mm (1/38 = 2.63 %) and one case in a group with a neoplasms diameter of 20-25 mm (1/5 = 20 %).Conclusions. Cold endoscopic snaring resection of colorectal epithelial neoplasms with preliminary hydropreparation in the submucosa is a safe and effective method of excisions superficially epithelial neoplasms of the colon with a diameter of 5 to 19 mm.
Treatment of Functional Dyspepsia in Outpatients after COVID-19 Infection
Authors: Turchina M. S. , Morozov Yu. M. , Obolenskaya T. I. 
Published: May 2023

Aim: to compare the efficacy of different therapeutic regimens for managing functional dyspepsia in outpatients after COVID-19 infection.Materials and methods. 42 post-COVID-19 outpatients (age: 26–47 years) diagnosed with functional dyspepsia (FD) according to the Rome IV Criteria were enrolled in two parallel groups. All patients were divided in 2 groups by randomization: Group 1 received omeprazole at a dose of 80 mg/day, Group 2 received a combination of omeprazole and Kolofort® (a combined action drug product containing technologically processed antibodies to S100, TNF-alpha, and histamine) at a dose of 80 mg/day. At baseline and after treatment, a 10-point VAS was used to measure symptoms and an SF-36 questionnaire to evaluate the quality of life.Results. By Day 28 of the treatment, the intensity of epigastric pain (VAS score) in the group receiving proton-pump inhibitor (PPI) + Kolofort® was significantly lower. In both groups, fully resolved dyspeptic syndrome was observed in up to 90 % of patients, without significant differences (p < 0.06). According to the SF-36 data, a combination treatment resulted in higher scores (pain and general health subscales) as compared to the PPI alone.Conclusion. Kolofort® relieves symptoms and improves the quality of life when added to the treatment regimen against functional dyspepsia in post-COVID-19 patients.
Antiphospholipid Syndrome as a Cause of Recurrent Portal Vein Thrombosis in a Man with a Medical History of other Thrombosis
Authors: Sayfutdinov R. G. , Saifutdinov R. R. , Akhunova R. R. , Saifutdinova T. V. , Absalyamova G. R. , Dvoryankina T. V. , Akhunova G. R. 
Published: May 2023

Aim: to present a clinical case of antiphospholipid syndrome (APS) manifested as recurrent portal vein thrombosis in a man with a medical history of other thromboses.Key points. APS is a syndrome that includes venous and/or arterial thrombosis, various forms of obstetric pathology, thrombocytopenia, as well as a variety of neurological, skin, cardiovascular and hematological disorders. The article presents a clinical case of a male patient with several episodes of vascular thrombosis, two of which (thrombophlebitis of the veins of the lower extremities and stroke) developed at the age of 39 years, and recurrent thrombosis of the portal vein since 2018. For several years, the patient had the diagnosis of cirrhosis based on the presence of signs of portal hypertension. However, the patient's liver function remained practically intact all the time. During the current examination, APS was suspected, and the result of a blood test for antibodies against phospholipids was positive.Conclusion. This clinical case of APS reflects the difficulties in diagnosing this disease. It should be remembered that cases of thrombosis at a young age may be due to APS.
Clinical Practice Guidelines of Russian Gastroenterological Association, Scientific Society for the Clinical Study of Human Microbiome, Russian Society for the Prevention of Non-Communicable Diseases, Interregional Association for Clinical Microbiology and Antimicrobial Chemotherapy for <i>H. pylori</i> Diagnostics and Treatment in Adults
Authors: Ivashkin V. T. , Lapina T. L. , Maev I. V. , Drapkina O. M. , Kozlov R. S. , Sheptulin A. A. , Trukhmanov A. S. , Abdulkhakov S. R. , Alekseeva O. P. , Alekseenko S. A. , Andreev D. N. , Bordin D. S. , Dekhnich N. N. , Klyaritskaya I. L. , Korochanskaya N. V. , Osipenko M. F. , Poluektova E. A. , Sarsenbaeva A. S. , Simanenkov V. I. , Tkachev A. V. , Ulyanin A. I. , Khlynov I. B. , Tsukanov V. V. 
Published: May 2023

Aim: bring to the attention of practitioners indications for anti-Helicobacter therapy, methods and procedure for diagnostics and eradication therapy ofН. pyloriinfection.Key points. Chronic gastritis caused byН. pyloriinfection, including asymptomatic persons, may be considered as an indication for eradication therapy of Н. pylori as etiological therapy and opportunistic screening for gastric cancer prevention. Indications, for obligatory anti-Helicobacter therapy include peptic ulcer, gastric MALT lymphoma, early gastric cancer (EGC) with endoscopic resection. H. pylori primary diagnostics methods include13C-urea breath test,H. pyloristool antigen lab test, rapid urease test and serological method. The serological method cannot be used after anti-Helicobacter therapy.In RussiaH. pyloristrains' resistance to clarithromycin does not exceed 15 % in most regional studies. The first line therapy forН. pyloriinfection eradication is the standard triple therapy including a proton pump inhibitor (PPI), clarithromycin and amoxicillin, enhanced with bismuthate tripotassium dicitrate. A classic four-component therapy based on bismuthate tripotassium dicitrate or quadrotherapy without bismuth drug products which includes PPI, amoxicillin, clarithromycin and metronidazole, may be used as alternative to the first line eradication therapy. The standard triple therapy may be prescribed for 14 days only in those regions, where it has been proven to be effective. Quadrotherapy with bismuthate tripotassium dicitrate is also used as main second line therapy in case of standard triple therapy, bismuth enhanced standard triple therapy or combined therapy failure. Another second line therapy includes PPI, levofloxacin and amoxicillin, to which a bismuth-containing drug product may be added. The third line therapy is selected individually based on previously used treatment settings.Conclusion. In each case ofH. pyloriinfection the decision for eradication therapy should be made, which is especially relevant as eradication ofH. pylorihas been recognized as an effective measure for the prevention of gastric cancer.
<strong>Protective </strong><em><strong>Renalase</strong></em><strong>-deficiency in beta cells shapes immune metabolism and function in autoimmune diabetes</strong>
Authors: Bode Kevin , MacDonald Tara , Stewart Taylor , Mendez Bryhan , P. Cai Erica , Morrow Noelle , Lee Yu-Chi , Yi Peng , Kissler Stephan 
Published: May 2023

<p>Type 1 diabetes (T1D) is caused by the immune-mediated loss of pancreatic beta cells that produce insulin. The latest advances in stem cell (SC)-beta cell differentiation methods have made a cell replacement therapy for T1D feasible. However, recurring autoimmunity would rapidly destroy transplanted SC-beta cells. A promising strategy to overcome immune rejection is to genetically engineer SC-beta cells. We previously identified <em>Renalase </em>(<em>Rnls</em>) as a novel target for beta cell protection. Here we show that <em>Rnls </em>deletion endows beta cells with the capacity to modulate the metabolism and function of immune cells within the local graft microenvironment. We used flow cytometry and single-cell RNA sequencing to characterize beta cell graft-infiltrating immune cells in a mouse model for T1D. Loss of <em>Rnls</em> within transplanted beta cells affected both the composition and the transcriptional profile of infiltrating immune cells in favor of an anti-inflammatory profile with decreased antigen presenting capacity. We propose that changes in beta cell metabolism mediate local immune regulation and that this feature could be exploited for therapeutic goals. </p>
Pembelajaran Daring Pada Masa Pandemi Covid-19 Oleh Guru-Guru IPA di Sekolah Menengah Pertama
Authors: Hantari Ida Ayu Putu Surya , Redhana I Wayan , Swasta Ida Bagus Jelantik 
Published: May 2023

Pembelajaran daring dilaksanakan sebagai langkah tepat untuk dapat mencegah dan menekan penularan virus covid-19, sehingga peserta didik tidak akan ketinggalan pelajaran sebagaimana yang telah direncanakan dalam kurikulum selama satu tahun ajaran. Penelitian ini bertujuan untuk menganalis pembelajaran daring pada masa pandemi covid-19 oleh guru-guru IPA di sekolah menengah pertama. Penelitian ini menggunakan jenis penelitian kualitatif. Data penelitian diperoleh dengan teknik pengumpulan data yaitu observasi, wawancara, dan dokumentasi. Subjek penelitian ini adalah kepala sekolah, guru-guru ipa dan guru mata pelajaran lainnya. Teknik analisis data menggunakan reduksi data, penyajian data, verifikasi data dan kesimpulan. Hasil penelitian menunjukkan bahwa yang dialami guru dalam penerapan kebijakan pemerintah tentang pembelajaran daring, perencanaan, pelaksanaan, dan evaluasi yaitu meliputi penerapan pembelajaran daring yang dari kebijakan pemerintah menjadi tantangan bagi guru dalam proses pembelajaran dan dirasa kurang maksimal, platform-platform pendukung pembelajaran daring yang asing bagi guru-guru karena minimnya pengetahuan tentang teknologi, persiapan yang ekstra agar siswa tidak merasa bosan dan jenuh saat pelaksanaan pembelajaran daring, kouta, jaringan serta alat pendukung yang kurang, (evaluasi yang dirasa kurang karena tidak bertatapan langsung membuat guru kesulitan dalam melakukan evaluasi. Adapun kendala-kendala yang dialami dapat menjadi tantangan bagi guru agar lebih meningkatkan lagi pelaksanaan pembelajaran daring serta pembelajaran yang kurang efektif perlu diperbaiki untuk pembelajaran selanjutnya.
Mathematical Model Simulation of Non-Linear Equations using MATLAB: Specific Volume of Gas with Van der Waals Equation
Authors: Amalia Ayu Fitri , Budhi Widodo , Melati Asih , Prabowo Urip Nurwijayanto 
Published: May 2023

Computational physics is concerned with the application of numerical methods in solving physical problems. The van der Waals gas model is one of the most common non-linear models. This study simulated a mathematical model of a non-linear equation using MatLab for the case of the specific volume of gas in the equation of the state of van der Waals. This study aimed to determine the molar volume and compressibility factor, as well as describe the relationship between the compressibility factor and the reduced pressure. The method of the study is experimental. The independent variables are the reduced pressure and temperature values. The dependent variable is the determination of the value of the molar volume (V) and the compressibility factor (Z). The control variable, in the form of a function used in solving this case, is based on van der Waals equation with the gas used is ammonia. The fzero command can be used to solve f(x)=0 with a single variable. This program that has been running successfully can show various predictions in the form of reduction pressure, thus obtaining the values of the molar volume and compressibility factor using the ideal gas equation. There is a deviation in ammonia gas, the Z1 at high reduction pressures and Z1 at medium pressures. This study can provide contributions and benefits in the form of material enrichment of thermodynamics to understand how real gases behave. The ideal gas equation can be modified into the van der Waals equation.
АНАЛИЗ И ПРОЕКТИРОВАНИЕ ПЛАСТИН И ПАНЕЛЕЙ ИЗ КОМПОЗИЦИОННЫХ МАТЕРИАЛОВ
Authors: Селюгин Сергей 
Published: May 2023

Рассматриваются задачи анализа и проектирования композиционных пластин и панелей. Указаны требования к конструкциям, которые должны быть выполнены при этом. Рассматриваются возможные как прямо-, так и криволинейно уложенные слои, составляющие пластину.
Изучаются задачи оптимизации укладки для трех видов поведения конструкций:
1)	до достижения границы упругой устойчивости
2)	при умеренных закритических прогибах в рамках теории фон Кармана
3)	при сильных закритических прогибах
Проанализированы и, где необходимо, выведены соответствующие вариационные принципы.
Получены необходимые условия локальной оптимальности первого порядка для наилучших укладок. Выполнен анализ этих условий.
Указана важная роль локально ортотропных решений для наилучших укладок.
ANALISIS STRUKTUR PELAT LANTAI BETON KONVESIONAL DAN PELAT LANTAI BONDEK (GEDUNG KULIAH FAKULTAS TARBIYAH DAN KEGURUAN UIN RADEN INTAN LAMPUNG)
Authors: Kusmila Widya , Herni Mas , Dewi Sari Utama 
Published: May 2023

Pekerjaan pelat merupakan salah satu elemen dari konstruksi yang membutuhkan waktu lama dalam proses pembuatannya dan merupakan elemen pada konstruksi gedung yang memiliki biaya besar. Salah satu alternatif pelat tersebut adalah pelat lantai bondek (steel deck). Analisa yang dilakukan adalah membandingkan pekerjaan pelat lantai beton konvensional dan pelat lantai bondek. Tujuan yang ingin dicapai dalam penulisan tugas ini adalah menganalisis struktur dari pelat lantai beton konvensional dan pelat lantai bondek serta menentukan metode mana yang lebih efektif dan efisien. Dari penelitian yang sudah dilakukan maka didapatkan (1) untuk tulangan pelat lantai beton konvensional menggunakan (Ø10 – 125) arah x, dan (Ø10 – 150) arah y. Sedangkan untuk tulangan wiremesh menggunakan M8 – 150 dan menggunakan bondek dengan tebal standar 0,75 mm; (2) Pelat lantai beton konvensional lebih murah dibandingkan pelat lantai bondek; (3) Pelat lantai beton konvensional lebih hemat 11% dibandingkan pelat lantai bondek (4) Pelat bondek lebih cepat dalam waktu pelaksanaannya dibandingkan pelat beton konvensional. Berdasarkan dari hasil tersebut, untuk pemilihan pekerjaan pelat lantai direkomendasikan untuk menggunakan pelat bondek untuk menghemat waktu pekerjaan dan pelat lantai konvensional untuk menghemat biaya pekerjaan.
PENGARUH STABILISASI TANAH GAMBUT MENGGUNAKAN CAMPURAN ZAT ADDITIVE BERUPA DIFA SOIL STABILIZER DAN SEMEN TERHADAP KUAT TEKAN DAN KUAT GESER TANAH
Authors: Permadi Iwan 
Published: May 2023

Penambahan zat additive berupa difa soil stabilizer dapat memperbaiki atau meningkatkan daya dukung sifat mekanis tanah asli. Nilai PI semakin menurun dan tingkat kepadatan semakin meningkat serta kuat geser tanah berkurang. Sedangkan untuk pengujian kuat geser tanah yang dilakukan di Laboratorium Mekanika Tanah Teknik Sipil Universitas Muhammadiyah Metro, dari ke empat sampel yang telah diujikan dengan campuran zat additive difa soil stabilizer yakni 0,2%, 0,4%, 0,6%, 0,8% + 8% semen dalam setiap pengujian kuat geser campuaran. Dari ke empat pengujian nilai tegangan geser rata-rata yang paling tinggi adalah pada penelitian ini yakni dengan campuran 0,8% difa soil stabilizer + 8% semen mendapat kadar campuran dengan nilai tegangan geser rata-rata 0,503 kg/cm2 dan mendapatkan nilai kohesi 0,11 kg/cm2, sedangkan untuk sudut geser dalam mendapatkan nilai 32,94˚. Sedangkan hasil dari pengujian pemadatan tanah campuran zat additive difa soil stabilizer mendapatkan kadar campuran maksimum 0,8% difa soil stabilizer + 8% semen dengan kadar air optimum 38,20%, dengan berat kering maksimum 1,15 gr/cm3. Nilai berat isi kering maksimum (γdmak) cenderung semakin meningkat dari tanah aslinya, sedangkan kadar air optimum (OMC) selalu mengalami penurunan, ini dikarenakan semakin meningkatya persentase penambahan campuran zat additive difa soil stabilizer oleh sebab itu tanah semakin kekurangan air.