bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of the effect of olive oil and its derivatives with atorvastatin in mitigating physiological and histological disorders due to hyperlipidemia in male rats
Authors: Abdulhammed Ahmad Aljaff Dlawer , Assi Ahmed Qays , Abbawe Salih Amjed 
Published: July 2023

Introduction: Hyperlipidemia destroys liver tissue, increasing liver enzymes. Increases liver extract ferritin, kidney and liver iron, while decreasing Hepcidin hormonal levels. Olive oil, hydroxytyrosol, and Atorvastatin were compared on liver enzymes, HMG-reductase activity, ferritin, hepcidin hormone, and iron deposition in liver and kidney tissues in experimental hyperlipidemic albino male rats.

Methodology: The experiment involved 50 albino rats grouped into two (control and test) of 25 rats each, then divided into 5 groups of 5 rats each. Animals in the first control group (blank) were fed the standard diet and gavaged distilled water for eight weeks, whereas the second to fifth groups of the first subgroup were fed the same standard diet for eight weeks followed by oral gavage with olive oil, hydroxytyrosol, olive oil + hydroxytyrosol, and atorvastatin, respectively, from the third week. Animals in the first test group were fed a diet containing 2% cholesterol for the duration of the experiment, whereas rats in the seventh, eighth, ninth, and tenth test groups were fed a high-cholesterol diet 2% for two weeks, followed by oral gavage with olive oil extract for the seventh group, hydroxytyrosol for the eighth group, olive oil extract + hydroxytyrosol for the ninth group, and a drug Atorvastatin for the tenth.

Results: Hyperlipidemia significantly increased the concentrations of liver enzyme in serum, ferritin and iron deposition in liver and kidney tissues, while decreasing the HMG-reductase activity and hepcidin hormonal levels in liver extract was seen in hyperlipidemia group in comparison to healthy controls. While the groups of treated animals showed a significant enhancement in each of the aforementioned factors, as olive oil extract + hydroxytyrosol outperformed all treatments.

Conclusion: Hypercholesterolemia increases liver enzymes, ferritin, and iron deposition while lowering hepcidin hormone and HMG-reductase activity. Hypercholesterolemia was mitigated by olive oil extract and hydroxytyrosol.
Nuevo concepto de puente de vigas hinchables ligero, modular y portátil
Authors:   , Estruch i Tena Carles 
Published: July 2023

We propose to develop, build and validate a new Concept of Bridge composed of Inflatable Beams, Lightweight, Modular and Portable (PVH-LMP) for surface transport vehicles, which uses pressurized air-filled beams made of high performance composite fabrics as the primary load-bearing structural spanning members. It will be the most lightweight, modular, transportable and easy to set-up existing temporary bridge, with a much better ratio between load/weight compared to the current alternatives. Despite the promising features of the concept, these beams have not reach the market yet and their use is limited to academics and research groups far from the industry. Scaled prototypes of PVH-LMP using a wide variety of commercial fabrics have been developed by Buildair in the past few years and used to demonstrate the conceptual feasibility of such beams.
Se propone desarrollar, construir y validar experimentalmente un nuevo Concepto de Puente de Vigas Hinchables Ligero, Modular y Portátil (PVH-LMP) para el transporte en superficie de vehículos, que utiliza como elemento básico estructural para aguantar las cargas vigas hinchadas con aire a baja presión fabricadas con tejidos compuestos de altas prestaciones. Una vez construido será el puente temporal más ligero, modular, transportable y fácil de montar disponible, con mucha mejor relación carga/peso en comparación con las alternativas de despliegue rápido existentes. A pesar de las características prometedoras del concepto, este tipo de vigas todavía no han llegado al mercado, y están limitadas a usos académicos y en grupos de investigación lejos del sector industrial productivo. Prototipos a escala de PVH-LMP, utilizando gran variedad de tejidos comerciales, han sido construidos por Buildair en los últimos años y usados para demostrar la viabilidad del concepto de dichas vigas.
ОНКОЕПІДЕМІОЛОГІЯ МЕЛАНОМИ ШКІРИ В ЧЕРНІГІВСЬКІЙ ОБЛАСТІ ТА ПРОБЛЕМИ ЇЇ РАННЬОЇ ДІАГНОСТИКИ
Authors: Алеврос Олександр , Полетай Вячеслав 
Published: July 2023

Мета роботи. Дослідити основні онкоепідеміологічні показники злоякісних меланоцитарних новоутворень шкіри в м. Чернігові та Чернігівській області, проаналізувати методи їх ранньої діагностики, визначити їх динаміку у період з 2014 по 2021 роки, проаналізувати ефективність профілактичних, діагностичних та лікувальних заходів в медичних закладах Чернігівської області за показниками 5-річного виживання пацієнтів з діагностованою меланомою шкіри.
Методологія. Проаналізовано статистичні дані Чернігівського медичного центру сучасної онкології та Національного канцер-реєстру України за період з 2014 по 2021 роки по основним показникам щодо меланоми шкіри: захворюваність, смертність та 5-річна виживаність; проведено аналіз наукової літератури щодо ранньої та диференційної діагностики меланоми шкіри.
Наукова новизна. Проаналізовано онкоепідеміологічні показники меланоми шкіри в Чернігівському регіоні за період з 2014 по 2021 роки, дана оцінка ефективності профілактичних, діагностичних та лікувальних заходів в медичних закладах Чернігівської області за показниками 5-річного виживання пацієнтів з діагностованою меланомою шкіри.
Висновки. Показники захворюваності на меланому шкіри та смертності від цього захворювання в м. Чернігові та Чернігівській області у період з 2014 по 2021 рр. не мають тенденції до збільшення, але виявилися вищими за показники по Україні в 1,4 рази. Показник 5-річного виживання має тенденцію до збільшення, що може свідчити про поступове вдосконалення методів профілактики, діагностики та лікування меланоми шкіри в медичних закладах Чернігівської області. Найчастіше діагностована друга стадія меланоми шкіри (половина всіх випадків), що свідчить про недостатній рівень онконастороженості населення. Визначені типові дерматоскопічні ознаки меланоми шкіри та її діагностичні алгоритми мають бути відомі лікарям первинної ланки, а населення, особливо з обтяженим анамнезом та наявністю передмеланомних новоутворень, має бути достатньо обізнане про необхідність моніторингу за змінами в новоутворенні і своєчасно звертатися до фахівців.
Pengaruh Lingkungan Kerja Terhadap Kinerja Pegawai Di Kantor Bea Dan Cukai Kota Cirebon
Authors: Hendry Octa Ismail  
Published: July 2023

The purpose of this study was to determine the effect of the work environment on employee performance at the Cirebon City Customs and Excise Office. This study used the accidental sampling method with a sample of 37 employees. Data collection is done by filling out a questionnaire for the work environment with employee performance. Furthermore, the collected data was analyzed using SPSS 26.0 for Windows with a significance level (α) of 0.05. The results showed that there was an effect of the work environment, judging from the tcount value of the work environment variable (X) of 12,993 ≥t_table (0.68188). And based on the F test the independent variable is 168,189 or there is an influence because the Sig level is 0.00 or less than 0.05 (p <0.05) which means that the Work Environment variables together have a significant influence on Employee Performance. From these results, Ho is rejected and Ha is accepted..

ABSTRAK
Tujuan penelitian ini adalah untuk mengetahui pengaruh lingkungan kerja terhadap Kinerja pegawai di Kantor Bea dan Cukai Kota Cirebon. Penelitian ini menggunakan metode accidental sampling dengan sampel sebanyak 37 pegawai. Pengumpulan data dilakukan dengan pengisian kuesioner untuk lingkungan kerja dengan Kinerja pegawai. Selanjutnya data yang terkumpul dianalisa dengan menggunakan SPSS 26.0 for Windows dengan tingkat kemaknaan (α) 0.05. Hasil penelitian menunjukkan ada pengaruh lingkungan kerja melihat dari nilai thitung variabel lingkungan kerja (X) sebesar 12.993 ≥t_tabel (0,68188). Dan berdasarkan uji F variabel bebas sebesar 168.189 atau ada pengaruh karena tingkat Sig sebesar 0,00 atau lebih kecil dari 0,05 (p<0.05) yang berarti variabel Lingkungan Kerja secara bersama-sama mempunyai pengaruh yang signifikan terhadap Kinerja Pegawai. Dari hasil tersebut maka Ho ditolak dan Ha diterima.
TMPOP2 Inhibition Suppresses Pancreatic Cancer Cell Migration and Development by Repressing The JNK/STAT3 Pathway
Authors: Liang Jun , Cao Huangming , Wang Guangxue , Wei Liang , Dong Lin , Chen Guohan , Li Qinchuan , Zhu Dongyi 
Published: July 2023

AbstractPancreatic cancer is a malignancy with a poor prognosis and high mortality. The lincRNA TMPOP2 is highly expressed in gynecological cancers and may exhibit tumor‐promoting functions. However, the function of TMPOP2 in pancreatic cancer is limited. TMPOP2 expression in pancreatic cancer and adjacent tissues is analyzed from The Cancer Genome Atlas (TCGA) and GTEx database. It shows the high expression of TMPOP2 in pancreatic cancer tissues. Similar results are observed in resected pancreatic adenocarcinoma tumors and adjacent tissues from 20 patients and the relative cell lines. When the pancreatic cell lines are transfected with si‐TMPOP2, it shows that TMPOP2 downregulation inhibits the cells migration and EMT. Furthermore, the potential mechanism is explored by detecting the expression of c‐Jun N‐terminal kinase (JNK), phosphorylated JNK, signal transducer and activator of transcription 3 (STAT3), and phosphorylated STAT3. It suggests that TMPOP2 knockdown inactivates JNK and STAT3 phosphorylation. When a JNK activator (anisomycin) is added to the cells with si‐NC or si‐TMPOP2, it can partially reverse the migration and EMT inhibition of the cells with inhibited TMPOP2. TMPOP2 inhibition suppresses the migration and EMT of pancreatic cancer by repressing the JNK/STAT3 pathway. Thus, this may be a novel target for pancreatic cancer therapy.
A Reversible NIR‐II Ratiometric Fluorescent Probe for Real‐Time In Vivo ATP Detection
Authors: Liu Yunyi , Zhang Lu , Chen Ying , Sun Haitao , Chen Jiajian , El‐Toni Ahmed Mohamed , Khan Aslam , Lei Zuhai , Zhang Fan 
Published: July 2023

AbstractATP plays a prominent role in shaping the evolution of immune cell responses to injury, infection, and cancer. However, real‐time monitoring of ATP levels in vivo remains a challenge, due to the lack of reliable tools that work reversibly in deep tissues. Herein, based on the Förster resonance energy transfer (FRET) strategy, a reversible ratiometric second near‐infrared window (NIR‐II) molecular fluorescent probe (CX‐RATP) is designed and synthesized. CX‐RATP exhibits a significant fluorescence ratio change with the existence of 0–10 mM ATP in vitro, which is within the range of physiological and pathological ATP concentrations. Meanwhile, the recognition process can be reversed by apyrase. It can capture the increase and decrease in ATP levels in real time before and after the treatment of acute inflammation. Besides, CX‐RATP is also successfully applied to the hepatocellular carcinoma (HCC) model and achieves in situ imaging of tumor lesions. These results all provide solid proof that CX‐RATP is a powerful tool for in vivo real‐time ATP detection.
Large covariance estimation using a factor model with common and group‐specific factors
Authors: Yafeng Shi , Chunrong Ai , Shi Yanlong , Tingting Ying , Qunfang Xu 
Published: July 2023

AbstractThis paper proposes a new approach to estimate large covariance matrices using multilevel factor models. In order to further improve the efficiency of the principal orthogonal complement thresholding estimator (PEOT) and the proposed estimators, the generalized least squares (GLS) method is employed to refine the estimation of the factors. A novel approach to identify number of the factors is proposed for facilitating our estimation procedure. We prove the consistency of the covariance matrix estimators and the estimators for number of the factors. Our Monte Carlo simulations show that the proposed estimators have superior properties in finite samples for all different designs, and the efficiency can be improved significantly by using GLS. Finally, we apply our estimators to a dataset consisting of weekly returns of three major stock indexes constituents, and the results suggest that the proposed methods can improve the out‐of‐sample performances of portfolio optimization.
Effects of sinapic acid on lead acetate‐induced oxidative stress, apoptosis and inflammation in testicular tissue
Authors: Tuncer Sibel Çiğdem , Akarsu Serkan Ali , Küçükler Sefa , Gür Cihan , Kandemir Fatih Mehmet 
Published: July 2023

AbstractIn this study, the effect of lead acetate (PbAc) and sinapic acid (SNP) administration on oxidative stress, apoptosis, inflammation, sperm quality and histopathology in testicular tissue of rats was tried to be determined. PbAc was administered at a dose of 30 mg/kg/bw for 7 days to induce testicular toxicity in rats. Oral doses of 5 and 10 mg/kg/bw SNP were administered to rats for 7 days after PbAc administration. According to our findings, while PbAc administration increased MDA content in rats, it decreased GPx, SOD, CAT activity and GSH content. NF‐kB, IL‐1β, TNF‐α, and COX‐2, which are among the inflammation parameters that increased due to PbAc, decreased with the administration of SNP. Nrf2, HO‐1, and NQO1 mRNA transcript levels decreased with PbAc, but SNP treatments increased these mRNA levels in a dose‐dependent manner. RAGE and NLRP3 gene expression were upregulated in PbAc treated rats. MAPK14, MAPK15, and JNK relative mRNA levels decreased with SNP treatment in PbAc treated rats. While the levels of apoptosis markers Bax, Caspase‐3, and Apaf‐1 increased in rats treated with PbAc, the level of Bcl‐2 decreased, but SNP inhibited this apoptosis markers. PbAc caused histopathological deterioration in testis tissue and negatively affected spermatogenesis. When the sperm quality was examined, the decrease in sperm motility and spermatozoon density caused by PbAc, and the increase in the ratio of dead and abnormal spermatozoa were inhibited by SNP. As a result, while PbAc increased apoptosis and inflammation by inducing oxidative stress in testicles, SNP treatment inhibited these changes and increased sperm quality.
Diaryl-hemiindigos as visible light, pH, and heat responsive four-state switches and application in photochromic transparent polymers
Authors: Sacherer Maximilian , Hampel Frank , Dube Henry 
Published: July 2023

AbstractPhotoswitches are indispensable tools for responsive chemical nanosystems and are used today in almost all areas of the natural sciences. Hemiindigo (HI) derivatives have recently been introduced as potent photoswitches, but their full applicability has been hampered by the limited possibilities of their functionalization and structural modification. Here we report on a short and easy to diversify synthesis yielding diaryl-HIs bearing one additional aromatic residue at the central double bond. The resulting chromophores offer an advantageous property profile combining red-light responsiveness, high thermal bistability, strong isomer accumulations in both switching directions, strong photochromism, tunable acid responsiveness, and acid gating. With this progress, a broader structural realm becomes accessible for HI photoswitches, which can now be synthetically tailored for advanced future applications, e.g., in research on molecular machines and switches, in studies of photoisomerization mechanisms, or in the generation of smart and addressable materials. To showcase the potential of these distinct light-responsive molecular tools, we demonstrate four-state switching, chemical fueling, and reversible inscription into transparent polymers using green and red light as well as acid/base stimuli, in addition to a comprehensive photochemical study of all compounds.
Research on fast-charging battery thermal management system based on refrigerant direct cooling
Authors: Dai Naichang , Long Jiangqi 
Published: July 2023

AbstractAiming at the problem of high battery heat generation during the super fast-charging process of electric vehicle fast-charging power batteries, this study designs a fast-charging battery thermal management system based on the refrigerant direct cooling architecture. In order to use the refrigerant of refrigerant to cool the battery quickly. Firstly, the study constructs the heat generation model of the power battery, the calculation model of the battery thermal management system, and builds the experimental device. Secondly, theoretical simulations and experimental studies were conducted for low-temperature fast-charging and high-temperature fast-charging operating conditions. The experimental results show that the designed battery thermal management system has good cooling effect and temperature uniformity.
Research with children, weeds, and a book
Authors: Deszcz-Tryhubczak Justyna 
Published: July 2023

Abstract
In this chapter, Justyna Deszcz-Tryhubczak looks back at an encounter with weeds, a seemingly unimportant moment in a child-led research project that has nevertheless continued to arrest her attention long after the completion of her collaboration with the children. She uses the concept of after childhood (Kraftl 2020) and the notions of attentiveness and curiosity developed in multispecies studies (van Dooren, 2018; van Dooren et al. 2016; van Dooren & Rose, 2016) to speculate retrospectively about possible movements of the research focus away from the child participants and the book they studied with her towards the plants and their lifeworld. Reflecting on the common world that might have emerged in the project as a result of these shifts, she argues for the thematic, methodological, and ethical importance of human and more-than-human entanglements in children’s literature and culture studies in the Anthropocene.
Health Problems
Authors: Barnes Elizabeth 
Published: July 2023

Abstract
Health is weird. Health is weird in a way that resists simple explanations or elegant theorizing. This book is a philosophical explanation of that weirdness and an argument that grappling with the distinctive weirdness of health can give us insight into how we might approach difficult questions about social reality. After examining extant theories of health—and finding them lacking—the book explores some particularly intractable puzzles about the nature of health, places where we often feel pulled in multiple directions or have reason to say conflicting things. On the basis of these puzzles, the book then defends a stance called ameliorative skepticism. Although health is real, there is, on this view, no way of giving a coherent, explanatorily adequate answer to the question “what is health?”. Yet adopting this skeptical stance can, it is argued, help us to better understand the role that health plays in our lives and the work that we need a theory of health to do.
The Science of Dignity
Authors: Hitlin Steven , Andersson Matthew A. 
Published: July 2023

Abstract
This book provides original evidence arguing for dignity as an indicator of public health by offering a scientific framework for measuring dignity and its social determinants. Like happiness or love, dignity is valued by individuals but difficult to define. Across centuries of philosophical thought and decades of social science research, dignity involves how individuals and societies relate in a way that preserves and nurtures both, a veritable bedrock of democracy. The book shows that dignity can be efficiently measured by using simple survey items that ask individuals whether there is “dignity” in their life or in how they are treated by others. It finds that unhappiness, sadness, anger, and lower general health are far more common for those reporting undignified lives. “Dignity threat” affected 21.5% of Americans in 2021, representing more than a 50% increase from 2017. Across America, differences in dignity come from inequalities in social and economic resources and from experiences of disrespect, threat, and life stress—and from mastery, mattering, and meaning. Social groups with less power generally report lower levels of dignity linked to these multifaceted resource and stress inequalities. Individuals disadvantaged by race, gender, age, or disability suffer from greater indignity, and a four-year college education delineates profound resource divides in America. Polarization itself, in terms of perceived threat from other social groups, is linked to indignity. Even amid diverse moralities, however, dignity demonstrates wide value in America. By foregrounding life’s sanctity, dignity provides a scientific basis for collective consensus and social inspiration.
The formulation of anti-vaccination mandate views in social work
Authors: Beddoe Liz 
Published: July 2023

INTRODUCTION: A feature of the Covid-19 pandemic in Aotearoa New Zealand was the introduction of mass vaccination and vaccine mandates as public health measures to minimise serious illness and deaths. These measures were generally popular, with wide support, and 90% uptake of vaccines across the eligible population. A minority, however, objected strenuously to both mass vaccination and mandates. In a stressful period, this opposition and the unrest generated significant conflict. Social work was not immune to this conflict.
Approach: This commentary explores the nature of dissent in social work about vaccines in Aotearoa New Zealand after August 2021, drawing on theoretical explanations of vaccine hesitancy and refusal. Social theory is helpful in unpacking arguments for and against public health initiatives.
Conclusions: Opposition to vaccine mandates has been framed as legitimate dissent where freedom and rights are largely conceptualised within a lens of neoliberal individualism. Social work values heavily weigh in on the side of a collectivist public health approach and this does not negate human rights.
Elemental Sulfur and Its Isotopic Composition in the Black Sea Water
Authors: Dubinin A. V. , Demidova T. P. , Semilova L. S. , Rimskaya-Korsakova M. N. , Dubinina E. O. , Kossova S. A. , Zologina E. N. 
Published: July 2023

Abstract
As one of the main intermediate products of hydrogen sulfide oxidation, elemental sulfur plays an important indicator role in understanding the oxidative cycle of sulfur in the water of anoxic basins. The distribution of elemental sulfur in the water column of the Black Sea at stations located in the area of the continental slope is considered. For the first time, the concentration distributions of two forms of elemental sulfur depending on the depth in the Black Sea water were obtained: suspended elemental sulfur with a fraction of more than 0.45 μm (S0) and zero-valency sulfur (ZVS), which includes the sum of elemental sulfur (suspended and colloidal) and polysulfide sulfur. In the upper anoxic waters, the concentration of S0 noticeably increases (almost 200 times relative to the depth of 400 m) with an increase in the concentration of hydrogen sulfide and the density of water. At depths of more than 250 m, the concentration of both forms of sulfur remains almost constant (ZVS = 0.21 ± 0.03 µmol/kg, S0 = 0.05 ± 0.01 µmol/kg). A sharp increase in the concentration of S0 at the depths of 150–250 m is associated with the oxidation of hydrogen sulfide due to bacterial anoxygenic photosynthesis after sampling. The value of δ34S(ZVS) was determined in the waters of two stations Ash-26 and 149 at the depths of 450 and 600 m, respectively, which turned out to be +2.2‰ higher than δ34S(Н2S) from the same depths, which indicates the bacterial origin of elemental sulfur.