bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical significance of the estimation of pulmonary-right ventricular uncoupling in patients with transthyretin amyloid cardiomyopathy
Authors: Usuku Hiroki , Yamamoto Eiichiro , Miyazaki Kasumi , Higashi Ryudai , Nozuhara Atsushi , Oike Fumi , Kuyama Naoto , Tabata Noriaki , Ishii Masanobu , Hanatani Shinsuke , Hoshiyama Tadashi , Kanazawa Hisanori , Sueta Daisuke , Arima Yuichiro , Oda Seitaro , Kawano Hiroaki , Matsuzawa Yasushi , Izumiya Yasuhiro , Ueda Mitsuharu , Tanaka Yasuhito , Tsujita Kenichi 
Published: January 2025

Abstract

Aims
There are few data on the prognostic impact of pulmonary-right ventricular (RV) uncoupling in patients with wild-type transthyretin amyloid cardiomyopathy (ATTRwt-CM).

Methods and results
Among the 174 patients who were diagnosed with ATTRwt-CM at Kumamoto University Hospital from 2002 to 2021, 143 patients who met the current Japanese guideline and had sufficient information for two-dimensional speckle tracking echocardiography were retrospectively analysed. During a median follow-up of 1209 days, 39 cardiac deaths occurred. Compared with patients in the non-event group, those in the cardiac death group were significantly older (79.3 ± 6.7 vs. 76.4 ± 6.2, respectively; P &lt; 0.05). Additionally, RV global longitudinal strain (RV-GLS)/systolic pulmonary artery pressure (sPAP), an index of pulmonary-RV uncoupling, was significantly lower in patients in the cardiac death group vs. the non-event group [0.29 (0.18–0.35) vs. 0.40 (0.29–0.57), P &lt; 0.01]. Multivariate Cox proportional hazards regression analysis demonstrated that RV-GLS/sPAP was significantly associated with cardiac death after adjusting for tricuspid annular plane systolic excursion/sPAP (P &lt; 0.01), sPAP (P &lt; 0.05), and conventional prognostic factors including age and hospitalization for heart failure (&lt;0.01), laboratory finding including high-sensitivity cardiac troponin T, and B-type natriuretic peptide (P &lt; 0.01). Receiver operating characteristic analysis showed that the area under the curve for RV-GLS/sPAP for cardiac death was 0.72 and that the best cut off value for RV-GLS/sPAP was 0.34 (sensitivity, 76%; specificity, 65%). In the Kaplan–Meier analysis, patients with ATTRwt-CM who had low vs. high RV-GLS/sPAP (cut-off value 0.34) had a significantly higher probability of cardiac death (P &lt; 0.01).

Conclusion
Pulmonary-RV uncoupling has significantly higher prognostic value compared with conventional prognostic factors in ATTRwt-CM.
Association between mobility decline and health literacy in older Japanese adults: Onjuku study
Authors: Asakura Nanako , Yamaguchi Satoshi , Matsuura Yusuke , Hagiwara Shigeo , Hashimoto Eiko , Horii Manato , Inage Kazuhide , Kawarai Yuya , Kimura Seiji , Maki Satoshi , Shiga Yasuhiro , Arima Saburo , Ohtori Seiji 
Published: January 2025

Abstract
Decline in mobility is a global issue that must be addressed in rapidly aging societies. We aimed to clarify the association between locomotive syndrome (LS), a condition of decreased mobility and health literacy (HL) in community-dwelling Japanese adults aged ≥ 40 years. A descriptive survey was conducted in Onjuku Town, Japan, between 2019 and 2023. The participants performed LS risk tests, including the two-step test, stand-up tests and 25-question geriatric locomotive function scale, to assess mobility. They completed the 14-item health literacy scale to quantify the total HL and functional, communicative and critical HL subscales. Other participant characteristics, such as chronic diseases, bodily pain and physical activity, were also surveyed. The association between LS and HL was assessed using univariate and multivariate logistic regression analyses, adjusted for participant characteristics. We analyzed 492 participants with a median age of 71 years. The total HL score decreased as the LS stage increased, with 56, 54 and 51 points in stages 0, 1 and ≥ 2, respectively (p = 0.004). In the logistic regression analysis, a high total HL score was significantly associated with reduced odds of stage ≥ 2 LS (adjusted odds ratio, 0.95; p &lt; 0.001). Furthermore, functional HL score had an independent association with stage ≥ 2 LS (adjusted odds ratio, 0.88; p = 0.009). Our results suggest that clinicians should provide HL education in addition to known preventive measures, such as promoting physical activity, as a holistic approach to decreased mobility.
“This house belonged to Mendel Lis”: Poles Requesting Jewish Houses Immediately after the Holocaust
Authors: Weizman Yechiel 
Published: January 2025

Abstract
Offering a microhistorical analysis of the Polish population’s vocabulary and language during the postwar allocation of Jewish real estate to non-Jewish Poles—this article shows how Poles negotiated, conceptualized, understood, and normalized this process. Analyzing the colloquial postwar discourse concerning Jewish houses and closely reading Polish inhabitants’ written requests reveals how Poles used various linguistic patterns to come to terms with the implications of the war, and establish their right to “inherit” their former neighbors’ property. Focusing on one town, the article provides a valuable glimpse into the atmosphere and norms that shaped Polish-Jewish relations from the end of the war to the present day. It also elucidates the ambivalences, unease, and uncertainties expressed in communal debates on the future of Jewish property.
Expression Profile of MicroRNAs in Breast Milk of Women With Inflammatory Bowel Disease: Correlation With Disease Activity and Medical Treatments
Authors: Golan-Gerstl Regina , Ben Ya’acov Ami , Musseri Mirit , Goldenberg Rosi , Chammah Yehudit , Cherki Tal , Reif Shimon , Bar Gil Shitrit Ariella 
Published: January 2025

Abstract

Background
Although most inflammatory bowel disease (IBD) medications are considered safe during pregnancy, their impact on microRNAs (miRNAs) in breast milk is largely unknown. MiRNAs in milk, carried by milk-derived extracellular vesicles (MDEs), are transmitted to the newborn’s gut to regulate genes. Aberrant miRNA expression profiles have been found in IBD within tissue, blood, and feces, but data on mother’s milk are scarce.

Methods
We collected breast milk samples from 32 mothers with Crohn’s disease (CD), 14 mothers with ulcerative colitis (UC), and 44 healthy controls. We analyzed miRNA expression through qualitative real-time polymerase chain reaction and Affymetrix miRNA chips. Target genes of differentially expressed miRNAs were predicted using miRATBase. Statistical analyses were conducted using GraphPad Prism software with Mann–Whitney tests.

Results
Milk-derived extracellular vesicles from mothers with IBD showed altered miRNA profiles compared to controls. Specifically, miR-21 and miR-320 were downregulated, while Let-7a was upregulated in IBD mothers. The expression patterns varied between CD and UC, with significantly lower MiR-21 in UC and higher Let-7a in CD. Additionally, anti-tumor necrosis factor treatment during pregnancy was associated with reduced miR-21 and miR-148a levels in MDEs. Pathway analysis revealed that these miRNAs are involved in immune regulation, particularly interleukin signaling pathways.

Conclusions
This study highlights that miRNAs in breast milk are differentially expressed in mothers with IBD, influenced by the disease and its treatments. These findings emphasize the impact of maternal health on milk composition and potential implications for infant immune development. Understanding these findings may guide personalized treatment strategies for mothers and promote breastfeeding among mothers with IBD.
Beyond MACS: physical properties of extremely X-ray luminous clusters at z &gt; 0.5
Authors: Ebeling H , Richard J , Beauchesne B , Basto Q , Edge A C , Smail I 
Published: January 2025

ABSTRACT
We present a sample of over 100 highly X-ray luminous galaxy clusters ($L_{\rm X, 0.1-2.4\, keV} \sim 10^{45}$ erg s$^{-1}$) at $z\sim 0.5$–0.9, discovered by the extended Massive Cluster Survey (eMACS) in ROSAT All-Sky Survey (RASS) data. Follow-up observations of a subset at higher resolution and greater depth with the Chandra X-ray Observatory are used to map the gaseous intracluster medium, while strong-gravitational-lensing features identified in Hubble Space Telescope imaging allow us to constrain the total mass distribution. We present evidence of the exceptional gravitational-lensing power of these massive systems, search for substructure along the line of sight by mapping the radial velocities of cluster members obtained through extensive ground-based spectroscopy, and identify dramatic cases of galaxy evolution in high-density cluster environments. The available observations of the eMACS sample presented here provide a wealth of insights into the properties of very massive clusters ($M_{200}\sim 10^{15}$ M$_\odot$) at $z\gt 0.5$, which act as powerful lenses to study galaxies in the very distant Universe. We also provide first assessments of the evolutionary state, galaxy populations, and large-scale environment of eMACS clusters and release to the community the cluster sample and supporting spectroscopic catalogues to further the understanding of the first generation of truly massive clusters to have formed in the Universe.
Association of classroom-level stressors with psychological distress in teachers
Authors: Titheradge D , Albajara Sáenz A , Hayes R , Ukoumunne O C , Ford T 
Published: January 2025

Abstract

Background
Poor mental health is highly prevalent among schoolteachers. Different occupational, contextual and personal factors have been identified as sources of their psychological distress.

Aims
To explore the association of classroom-level variables with teachers’ mental health over the course of an academic year.

Methods
This study included 80 primary schoolteachers and 2075 pupils from the STARS trial conducted in England, which explored the impact of the Incredible Years Teacher Classroom Management programme. Linear regression models examined the relationships between classroom-level predictor variables and teachers’ psychological distress, as measured by the Everyday Feeling Questionnaire, at 1 and 9 months into the school year. Predictor variables included classroom size and demographic composition, amount of teaching assistant support, and pupils’ mental health, as measured by the Strengths and Difficulties Questionnaire and the Pupil Behaviour Questionnaire. Analyses were adjusted for teacher length of service and trial arm status.

Results
One month into the school year, fully adjusted analyses showed that having a classroom with a higher proportion of male pupils was associated with worse teacher mental health. None of the classroom-level stressors were associated with teacher mental health at 9 months.

Conclusions
Classroom gender balance was associated with teacher’s mental health at the beginning but not at the end of the academic year. It is important to consider classroom-level variables when developing interventions and policies for teacher mental health.
Scenarios for the emergence of new microRNA genes in the plant Arabidopsis halleri
Authors: Pavan Flavia , Lacoste Eléanore , Castric Vincent , Legrand Sylvain 
Published: January 2025

Abstract
MicroRNAs (miRNAs) are central players in the regulation of gene expression in eukaryotes. The repertoires of miRNA genes vary drastically even among closely related species, indicating that they are evolutionarily labile. However, the processes by which they originate over the course of evolution and the nature of their progenitors across the genome remain poorly understood. Here, we analyzed miRNA genes in Arabidopsis halleri, a plant species where we recently documented a large number of species-specific miRNA genes, likely to represent recent events of emergence. Analysis of sequence homology across the genome indicates that a diversity of sources contributes to the emergence of new miRNA genes, including inverted duplications from protein-coding genes, rearrangements of transposable element (TE) sequences, and duplications of preexisting miRNA genes. Our observations indicate that the origin from protein-coding genes was less common than was previously considered. In contrast, we estimate that almost half of the new miRNA genes likely emerged from TEs. Miniature inverted-repeat TEs (MITEs) seem to be particularly important contributors to new miRNA genes, with the Harbinger and Mariner TE superfamilies representing disproportionate sources for their emergence. We further analyzed the recent expansion of a miRNA family derived from MuDR elements and the duplication of miRNA genes formed by two hAT transposons. Overall, our results illustrate the rapid pace at which new regulatory elements can arise from the modification of preexisting sequences in a genome and highlight the central role of certain categories of TEs in this process.
Spirituality among People Who Are Transgender: A Nationally Representative Examination and Comparison with Members of the Public
Authors: Hodge David R 
Published: January 2025

Abstract
Spiritual practices are important strengths for many members of the general public, but little is known about practices among transgender people. To address this gap in the literature, this study investigated the frequency with which self-identified transgender adults participate in a diverse array of spiritual practices and compared their level of participation with that of members of the general population. To conduct this nationally representative study, data were abstracted from the National Religion and Spirituality Survey 2020. Frequencies are reported for 17 spiritual practices, and logistic regression was used to determine differences in participation. The results indicate transgender adults participate in spiritual practices at levels equal to, or greater than, that of other adults. Transgender adults were significantly more likely than other adults to participate in 10 spiritual practices: yoga, meditation, tarot cards/fortune telling, fasting, attending other spiritual/religious groups, art, being in nature, writing, acts of protest, and teaching in a spiritual/religious setting. With one exception, moderate to large effects were observed across all 10 spiritual practices. The results highlight the importance of administering spiritual assessments with transgender clients to identify potential spiritual practices that might be operationalized to assist clients cope with or ameliorate problems.
Therapeutic effects and mechanisms of Juanbilijieqing fang in ameliorating gouty arthritis in a murine model
Authors: Zhou Biao , Li Wei , Luo Zhiqiang , Zhu Liguo , Yu Jie , Guo Yuxing , Li Wangyang , Xiong Hui , Lu Xiaolong 
Published: January 2025

Abstract
This study aims to assess the safety, efficacy, and mechanisms of Juanbilijieqing Fang in a mouse model of gouty arthritis. C57BL/6 mice were allocated into six groups: control, gouty arthritis model, and treatment groups receiving varying doses of Juanbilijieqing Fang (low, medium, high), along with a positive control group treated with febuxostat. Gouty arthritis was induced via MSU crystal injection following a high-fat diet. Mice were treated with Juanbilijieqing Fang or febuxostat, and safety was evaluated by measuring spleen, kidney, and liver indices. Efficacy was assessed by monitoring foot thickness, pain threshold, and biochemical markers, including serum uric acid (UA), myeloperoxidase (MPO), xanthine oxidase (XOD), and adenosine deaminase (ADA). Serum pro-inflammatory cytokines were analyzed, and intestinal inflammation and barrier integrity were examined through histological and molecular assays. Juanbilijieqing Fang did not significantly affect spleen, kidney, or liver indices, indicating its safety. Therapeutically, it significantly reduced foot swelling, improved pain threshold, and decreased serum uric acid levels. It also lowered MPO activity in foot tissue and reduced XOD and ADA activity in the liver. Additionally, the formula downregulated pro-inflammatory cytokines, such as IL-1α, IL-1β, IL-6, TNF-α, and IFN-γ, demonstrating a strong anti-inflammatory effect. It ameliorated gut inflammation by decreasing NLRP3 inflammasome components (NLRP3, ASC, and Caspase-1) and enhanced gut mucosal integrity by upregulating ZO-1 and Occludin expression. Juanbilijieqing Fang is a safe and effective treatment for gouty arthritis, primarily through reducing systemic and intestinal inflammation and restoring gut barrier function.
Heterotopic ossification: Current developments and emerging potential therapies
Authors: Bei Mingjian , Cao Qiyong , Zhao Chunpeng , Xiao Yaping , Chen Yimin , Xiao Honghu , Sun Xu , Tian Faming , Yang Minghui , Wu Xinbao 
Published: January 2025

Abstract
This review aimed to provide a comprehensive analysis of the etiology, epidemiology, pathology, and conventional treatment of heterotopic ossification (HO), especially emerging potential therapies. HO is the process of ectopic bone formation at non-skeletal sites. HO can be subdivided into two major forms, acquired and hereditary, with acquired HO predominating. Hereditary HO is a rare and life-threatening genetic disorder, but both acquired and hereditary form can cause severe complications, such as peripheral nerve entrapment, pressure ulcers, and disability if joint ankylosis develops, which heavily contributes to a reduced quality of life. Modalities have been proposed to treat HO, but none have emerged as the gold standard. Surgical excision remains the only effective modality; however, the optimal timing is controversial and may cause HO recurrence. Recently, potential therapeutic strategies have emerged that focus on the signaling pathways involved in HO, and small molecule inhibitors have been shown to be promising. Moreover, additional specific targets, such as small interfering RNAs (siRNAs) and non-coding RNAs, could be used to effectively block HO or develop combinatorial therapies for HO.
Gland- and cell-level heterogeneity in the prostate: A narrative review of related diseases
Authors: Wang Gang , Lv Cai , Liu Zhenxiang , Huang Mengxing , Zhang Yu , Chen Jing , Hu Jinyue , Jin Yiling , Bai Zhiming 
Published: January 2025

Abstract
Because of the anatomical characteristics of the prostate, benign prostatic hyperplasia (BPH) often occurs in the transition zone, whereas prostate cancer (PCa) tends to occur in the peripheral zone. This distribution characteristic indicates that the prostate gland has cell type and distribution heterogeneity. However, the current research cannot answer these questions precisely. As research has progressed, the significance of many newly discovered cell types for the treatment of BPH and PCa has sparked widespread concern. Prostate heterogeneity is closely associated with gland development and formation and the regional distribution of the disease. Prostate heterogeneity can be observed at the gland and cell levels and determines disease distribution, presentation, and characteristics, including changes in the microenvironments of BPH and PCa. Cell population interactions promote disease onset and development single-cell sequencing techniques may help elucidate specific cell types and gene expression patterns in different prostate zones. The stem cell characteristics of club/hillock cells and the inflammatory environment induced by immune cells offer alternative interpretations of the pathogenic mechanisms of BPH and PCa, and molecular omics studies can help identify novel avenues for treatment development.
Efficacy of the Direct Anterior Chamber Air Replacement Method During Descemet Stripping Automated Endothelial Keratoplasty
Authors: Ishikawa Sho , Maruyama Takafumi , Shinoda Kei 
Published: January 2025

Purpose:
This study aimed to describe a novel technique of direct anterior chamber (AC) air replacement (DACAR) for the management of Descemet stripping automated endothelial keratoplasty (DSAEK) in postvitrectomized eyes and eyes with previous glaucoma surgery.

Methods:
DACAR was performed after a corneal donor graft was transplanted through a wound using the pull-through technique. DACAR involves stabilizing the graft with forceps while introducing air into the AC via an infusion cannula to ensure complete air exchange. The air was maintained in the AC at all times using a vitrectomy machine. The air pressure was maintained at 30 mm Hg for 15 minutes.

Results:
The DACAR technique was performed in 34 patients, and conventional pull-through technique DSAEK was performed in 32 high-risk patients. The DACAR group had shorter DSAEK surgical procedures (P = 0.009) and a lower incidence of corneal graft detachment in the early postoperative period (P < 0.001) than the conventional DSAEK group.

Conclusions:
DACAR is performed in patients having previously undergone vitrectomy or glaucoma surgery to prevent corneal graft detachment during the early postoperative period and to reduce the length of surgery.
Decreasing Hospital-acquired Pressure Injuries During the COVID-19 Pandemic: A 5-step Quality Improvement Approach
Authors: Nuseir Deema , Sinno Maya , Wilson Mary-Agnes , Hacker Teper Matthew , Karasev Dmitry , Christian Shachi , Zimmerman Kate , Bakun Victoria , Linetska Natalya , Persaud Khem , Zhang Liandi , Li Crystal , Koo Lai Yi , Lefave Deborah , Stewart Heather , Taher Ahmed 
Published: January 2025

Background:
Hospital-acquired pressure injuries (HAPIs) are common adverse events with large burdens on patients and health systems. In 2020, during the initial waves of the COVID-19 pandemic, the incidence of admitted patients with HAPIs of stage II and above in our health system rose from 2.92% to 3.80%. In response to rising HAPI rates across our own hospital system, we established a quality aim to reduce HAPIs stage II and above by 50% over 3 years from the onset of the COVID-19 pandemic.

Methods:
We designed a multidisciplinary quality improvement HAPI prevention program. Our initiative had 5 key aspects: fostering governance and accountability, providing education and training, changing clinical practice, monitoring data and evaluation, and modernizing environments and equipment.

Results:
HAPI rate (outcome measure) declined from 3.8% at the onset of the COVID-19 pandemic to 1.6% (58% reduction, P<0.00001) postintervention. Braden Risk Assessment Tool use (process measure) improved from 88.2% to 92.2%. (P=0.00024). Rate of patient falls with injuries (balancing measure) decreased from 1.5 per 1000 patient days to 1.0 per 1000 patient days (P=0.0009).

Conclusions:
Despite working during the COVID-19 pandemic where organizational resources were constrained and infection control practices were heightened, a multidisciplinary QI HAPI prevention program, informed by evidence-based practices and supported by access to real-time data, led to an ∼58% reduction in the HAPI rate.