bluuebunny/crossref_metadata_2025_split huggingface dataset:
Menopausal hormone therapy is associated with worse levels of Alzheimer's disease biomarkers in APOE ε4‐carrying women: An observational study
Authors: Jauregi‐Zinkunegi Ainara , Gleason Carey E. , Bendlin Barbara , Okonkwo Ozioma , Hermann Bruce P. , Blennow Kaj , Zetterberg Henrik , Hogervorst Eef , Johnson Sterling C. , Langhough Rebecca , Mueller Kimberly D. , Bruno Davide 
Published: January 2025

AbstractINTRODUCTIONMenopausal hormone therapy (MHT), along with the apolipoprotein E (APOE) ε4 allele, has been suggested as a possible risk factor for Alzheimer's disease (AD). However, the relationship between MHT and cerebrospinal fluid (CSF) biomarkers is unknown: we investigated this association, and whether APOE ε4 carrier status moderates it.METHODSIn an observational study of 136 cognitively unimpaired female participants (Mage = 66.0; standard deviation = 6.3), we examined whether MHT use alone or in interaction with APOE ε4 carrier status was associated with CSF levels of phosphorylated tau (p‐tau), amyloid beta (Aβ)40, Aβ42, p‐tau/Aβ42, and Aβ42/40 ratios.RESULTSSignificant interactions were found between APOE ε4 and MHT use for CSF biomarkers. APOE ε4 carriers who were MHT users showed worse levels of CSF p‐tau/Aβ42 and Aβ42/40 ratios than all other users and non‐users.DISCUSSIONThe presence of both APOE ε4 and MHT may be associated with elevated amyloid deposition and AD pathology in this sample of participants who demonstrated high familial AD risk.Highlights
Significant interactions were found between apolipoprotein E (APOE) ε4 and menopausal hormone therapy (MHT) use for cerebrospinal fluid (CSF) phosphorylated tau (p‐tau)/amyloid beta (Aβ)42 and Aβ42/40 ratios.
APOE ε4 carriers who were MHT users showed worse levels of CSF biomarkers than non‐users and non‐carriers, both users and non‐users.
Younger age at MHT initiation was associated with worse levels of the p‐tau/Aβ42 and Aβ42/40 ratios in carriers only.
The presence of both APOE ε4 carriage and MHT use may be associated with elevated amyloid deposition and AD pathology.
Further studies with larger sample sizes are necessary to confirm the differences observed in the current study.
Early‐Life Adversity Predicts Markers of Aging‐Related Neuroinflammation, Neurodegeneration, and Cognitive Impairment in Women
Authors: Fleck Lara , Buss Claudia , Bauer Martin , Stein Maike , Mekle Ralf , Kock Lena , Klawitter Heiko , Godara Malvika , Ramler Judith , Entringer Sonja , Endres Matthias , Heim Christine 
Published: January 2025

ObjectiveDespite the overwhelming evidence for profound and longstanding effects of early‐life stress (ELS) on inflammation, brain structure, and molecular aging, its impact on human brain aging and risk for neurodegenerative disease is poorly understood. We examined the impact of ELS severity in interaction with age on blood‐based markers of neuroinflammation and neurodegeneration, brain volumes, and cognitive function in middle‐aged women.MethodsWe recruited 179 women (aged 30–60 years) with and without ELS exposure before the onset of puberty. Using Simoa technology, we assessed blood‐based markers of neuroinflammation and neurodegeneration, including serum concentrations of glial fibrillary acidic protein (GFAP) and neurofilament light chain (NfL). We further obtained T1‐weighted and T2‐weighted magnetic resonance images to assess brain volumes and we assessed cognitive performance sensitive to early impairments associated with the development of dementia, using the Cambridge Neuropsychological Automated Test Battery. We used generalized additive models to examine nonlinear interaction effects of ELS severity and age on these outcomes.ResultsAnalyses revealed significant nonlinear interaction effects of ELS severity and age on NfL and GFAP serum concentrations, total and subcortical gray matter volume loss, increased third ventricular volume, and cognitive impairment.InterpretationThese findings suggest that ELS profoundly exacerbates peripheral, neurostructural, and cognitive markers of brain aging. Our results are critical for the development of novel early prevention strategies that target the impact of developmental stress on the brain to mitigate aging‐related neurological diseases. ANN NEUROL 2025
Automated Detection of Isolated REM Sleep Behavior Disorder Using Computer Vision
Authors: Abdelfattah Mohamed , Zhou Li , Sum‐Ping Oliver , Hekmat Anahid , Galati Joanna , Gupta Niraj , Adaimi George , Marwaha Salonee , Parekh Ankit , Mignot Emmanuel , Alahi Alexandre , During Emmanuel 
Published: January 2025

ObjectiveIsolated rapid eye movement (REM) sleep behavior disorder (iRBD) is, in most cases, an early stage of Parkinson's disease or related disorders. Diagnosis requires an overnight video‐polysomnogram (vPSG), however, even for sleep experts, interpreting vPSG data is challenging. Using a 3D camera, automated analysis of movements has yielded high accuracy. We aimed to replicate and extend prior work using a conventional 2D camera.MethodsThe dataset included 172 vPSG recordings from a clinical sleep center, 81 patients with iRBD and 91 non‐RBD healthy controls (63 with a range of other sleep disorders and 28 healthy sleepers). An optical flow computer vision algorithm automatically detected movements during rapid eye movement (REM) sleep, from which features of rate, ratio, magnitude and velocity of movements, and ratio of immobility were extracted.ResultsPatients with iRBD exhibited an increased number of shorter movements and immobility periods. Accuracies for detecting iRBD ranged from 84.9% (with 2 features) to 87.2% (with 5 features). Combining all 5 features but only analyzing short (0.1–2 second duration) movements achieved the highest accuracy at 91.9%. Of the 11 patients with iRBD without noticeable movements during vPSG, 7 were correctly identified.InterpretationThis work improves prior art by using a 2D camera routinely used in sleep laboratories and improving performance by adding only 3 features. This approach could be implemented in clinical sleep laboratories to facilitate and improve the diagnosis of iRBD. Coupled with automated detection of REM sleep, it should also be tested in the home environment using conventional infrared cameras to detect and/or monitor RBD. ANN NEUROL 2025
Entschlüsselung der Polymer‐Interaktionen in Biokonjugaten unterschiedlicher Architektur durch zeitaufgelöste limitierte Proteolyse mit massenspektrometrischer Analyse
Authors: Hamm Prisca , Driessen Marc D. , Hauptstein Niklas , Kehrein Josef , Worschech Rafael , Pouyan Paria , Haag Rainer , Schubert Ulrich S. , Müller Thomas D. , Meinel Lorenz , Lühmann Tessa 
Published: January 2025

AbstractProtein‐Polymer Konjugate erlauben eine pharmakokinetische Optimierung von therapeutischen Proteinen. Allerdings sind die Interaktionen des Polymer‐ und des Proteinteils des Biokonjugates oftmals unbekannt, so dass eine Optimierung des molekularen Designs weitestgehend auf empirische Beobachtungen beschränkt ist. Dieser Artikel schließt diese analytische Lücke durch Kombination einer limitierten Proteolyse mit massenspektrometrischer Analyse (LiP‐MS). Zur Bestätigung der LiP‐MS wurden zunächst Interaktionen des IFN‐α2a mit seinem Rezeptor (IFNAR2) bestimmt, die sich mit publizierten Strukturen des Komplexes deckten. Interaktionen konnten dann detailliert am Beispiel von Biokonjugaten des Interferon‐α2a (IFN) mit Poly(ethylenglykol) (PEG) und PEG alternativen Polymeren beschrieben werden. Dazu wurde ein IFN‐Biokonjugat zusammen mit einem „schweren“ 15N‐IFN‐Wildtyp (IFN‐WT; interne Kontrolle) durch Trypsin verdaut und die Schnitterfolge am Biokonjugat mit denen am Wildtyp differentiell analysiert. Die Biokonjugate wurden mit 10 kDa PEG, linearem Poly(glycerol) (LPG) oder Poly(2‐oxazolin) (POX)über Cyclooctinlinker (BCN oder DBCO) ortsspezifisch mit Azid‐funktionalisiertem IFN‐α2a synthetisiert. LiP‐MS zeigte, dass die Interaktionsmuster der resultierenden Biokonjugate für PEG und LPG vergleichbar waren, nicht aber für POX, welches geringere Interaktionen mit dem Protein im Biokonjugat aufwies. Die mittels LiP‐MS gefundenen Wechselwirkungsprofile wurden durch atomistische Molekulardynamiksimulationen bestätigt und lassen kurzlebige Interaktionen des Polymerteils mit dem Proteinteil vermuten (<50 ns), zeigen aber auch die Abhängigkeit der Wechselwirkungen von dem verwendeten Polymer. Zusammengefasst gelingt es mittels zeitaufgelöster LiP‐MS‐Analyse, ein detailliertes Wechselwirkungsprofil des Polymerteils und des Proteinteils in Biokonjugaten zu kartieren. Die gut zu implementierende LiP‐MS Methode könnte dazu beitragen, die heute weitgehend noch empirischen Optimierungen von Biokonjugaten durch ein Hypothesen‐getriebenes Vorgehen zu ergänzen.
Intracellular Co‐Delivery of Carbon Monoxide and Nitric Oxide Induces Mitochondrial Apoptosis for Cancer Therapy
Authors: Shen Zhiqiang , Jiang Wei , Zheng Shaoqiu , Luo Siyuan , Guo Zixuan , Wang Qin , Wang Yucai , Hu Jinming 
Published: January 2025

AbstractUnderstanding the interplay between gasotransmitters is essential for unlocking their therapeutic potential. However, achieving spatiotemporally controlled co‐delivery to target cells remains a significant challenge. Herein, we propose an innovative strategy for the intracellular co‐delivery of carbon monoxide (CO) and nitric oxide (NO) gasotransmitters under clinically relevant wavelengths. This approach rationally couples aerobic photooxidative and anaerobic photocatalytic reactions within a polymeric micelle platform, using palladium(II) tetraphenyltetrabenzoporphyrin (PdTPTBP) as both photosensitizer and photocatalyst. Notably, the photooxidation‐mediated release of CO generates a local hypoxic microenvironment, which facilitates the photoredox catalyzed release of NO. This self‐adaptive micelle platform enables efficient uptake by tumor cells and intracellular co‐delivery of CO and NO under 630 nm light irradiation, demonstrating potent anti‐tumor activity in a 4T1 tumor‐bearing mouse model via the synergistic induction of mitochondrial apoptosis.
Covalent Adaptable Poly[2]rotaxane Networks via Dynamic C−N Bond Transalkylation
Authors: Bai Ruixue , Wang Wenbin , Gao Wenzhe , Zhang Zhaoming , Yu Wei , Yan Xuzhou 
Published: January 2025

AbstractCovalent adaptable networks (CANs), a novel class of crosslinked polymers with dynamic covalent bonds, have gained significant attention for combining the durability of thermosets with the reprocessability of thermoplastics, making them promising for emerging applications. Here, we report the first example of poly[2]rotaxane‐type covalent adaptable networks (PRCANs), in which oligo[2]rotaxane backbones characterized by densely packed mechanical bonds, are cross‐linked through dynamic C−N bonds. The oligo[2]rotaxane backbones could guarantee the mechanical properties of the CANs. Under an external force, the synergy of numerous microscopic motions of the cascade [2]rotaxane units, progressively introducing the initially hidden short chains, expands the polymer network, imparting good stretchability to the PRCANs (217 %). On the other hand, the dissociation of host‐guest recognition, followed by the motion of mechanical bonds, constitutes a unique energy dissipation pathway, ultimately enhancing the toughness of PRCANs (7.6 MJ/m3). In contrast, the control CAN, which lacks movable mechanical bonds, demonstrates significantly lower stretchability (40 %) and toughness (1.5 MJ/m3). Moreover, the dynamic C−N bond can undergo high efficiency of 1,2,3‐triazole alkylation and trans‐N‐alkylation exchanges at 1,2,3‐triazolium sites at elevated temperatures, with good reprocessability and without compromising their mechanical performance. This work demonstrates the great potential of oligo[2]rotaxanes as a novel polymer backbone for the development of sustainable materials with excellent mechanical properties.
Organic Crosslinked Tin Oxide Mitigating Buried Interface Defects for Efficient and Stable Perovskite Solar Cells
Authors: He Jiang , Zhang Jiyao , Zhang Yong , Xu Jiamin , Liang Zheng , Zhu Peide , Peng Wenbo , Qu Geping , Pan Xu , Wang Xingzhu , Xu Baomin 
Published: January 2025

AbstractTin dioxide (SnO2) stands as a promising material for the electron transport layer (ETL) in perovskite solar cells (PSCs) attributed to its superlative optoelectronic properties. The attainment of superior power conversion efficiency hinges critically on the preparation of high‐quality SnO2 thin films. However, conventional nanoparticle SnO2 colloids often suffer from inherent issues such as numerous oxygen vacancy defects and film non‐uniformity. In this study, we report a strategy to homogenize SnO2 with reduced defects for high‐performance PSCs. The commercial SnO2 colloid is modulated with bisphenol S (BPS) crosslinking to achieve a better annealing intermediate state. The phenolic hydroxyl groups on BPS bond with the hydroxyl groups on the SnO2 surface, passivating defects as well as promoting superb regularity of the films by forming a network of the SnO2 nanoparticles. Additionally, the sulfone groups on BPS coordinate with Pb2+, regulating the crystallization of PbI2 and FAPbI3, which leads to better interface contact at the buried interface. The FAPbI3 perovskite solar cells based on BPS‐crosslinked SnO2 layers achieved a champion efficiency of 24.87 % and retained 95 % of their initial PCE after 1000 hours of continuous light soaking under N2 atmosphere.
Anchorable Polymers Enabling Ultra‐Thin and Robust Hole‐Transporting Layers for High‐Efficiency Inverted Perovskite Solar Cells
Authors: Zhan Liqing , Zhang Shuo , Li Zhihao , Li Wenzhuo , Zhang Huidong , He Jingwen , Ji Xiaoyu , Liu Shuaijun , Yu Furong , Wang Songran , Ning Zhijun , Li Zhen , Stolterfoht Martin , Han Liyuan , Zhu Wei‐Hong , Xu Yisheng , Wu Yongzhen 
Published: January 2025

AbstractCurrently, the development of polymeric hole‐transporting materials (HTMs) lags behind that of small‐molecule HTMs in inverted perovskite solar cells (PSCs). A critical challenge is that conventional polymeric HTMs are incapable of forming ultra‐thin and conformal coatings like self‐assembly monolayers (SAMs), especially for substrates with rough surface morphology. Herein, we address this challenge by designing anchorable polymeric HTMs (CP1 to CP5). Specifically, coordinative pyridyl groups are introduced as side‐chains on poly‐triarylamine (PTAA) backbone with varied contents by copolymerization method, resulting in chemical interactions between polymeric HTMs and substrates. The strong interaction allows them to be processed into ultra‐thin, uniform, and robust hole‐transporting layers through employing low‐concentration solutions (0.1 mg mL−1, vs. 2.0–5.0 mg mL−1 for conventional PTAA), greatly decreasing charge transport losses. Moreover, upon systematically tuning the pyridyl substitution ratio, the energy levels, surface wetting, solution processability, and defect passivation capability of such anchorable HTMs are simultaneously optimized. Based on the optimal CP4, we achieved highly efficient inverted PSCs with power conversion efficiencies (PCEs) up to 26.21 %, which is on par with state‐of‐the‐art SAM‐based inverted PSCs. Furthermore, these devices exhibit enhanced stabilities under repeated current–voltage scans and reverse bias ageing compared with SAM‐based devices.
Biomass Tremella‐Derived Fe‐Fe3C‐Fe3O4 Incorporated Into Carbon–Nitrogen Catalyst for Chemoselective Hydrogenation of Nitroarenes
Authors: Li Xuewei , Sun Rui , Zhao Lishuang , Wang Jing , Wang Zirui , Li Weizuo , Wang Xin 
Published: January 2025

ABSTRACTA nitrogen‐doped carbon‐supported Fe‐Fe3C‐Fe3O4 composite (Fe‐Fe3C‐Fe3O4@CN) has been synthesized through a one‐step pyrolysis of an iron‐based complex (Fe@tremella‐est), in alignment with the principles of surface organometallic chemistry (SOMC). The Fe@tremella‐est complex was synthesized through a straightforward chelation process using N‐containing alanine‐modified tremella (tremella‐est) as the raw material. This approach enhances the resulting catalyst by providing a large specific surface area, high dispersity, and an increased number of Fe‐N species. These distinctive advantages confer upon Fe‐Fe3C‐Fe3O4@CN a higher catalytic efficiency compared with traditional catalysts (Fe‐Fe3C@CN and Fe‐Fe3C@CN‐550), along with enhanced stability during recycling experiments. This SOMC strategy may serve as a new framework for the synthesis of biomass‐derived nanocatalysts for various catalytic reactions.
Polyvinyl Alcohol Embedded Activated Clay/Hydroxyapatite Membranes for Fouling Control During the Removal of an Organic Dye in Water
Authors: Oduro Andrews Ayim , Biney Stephanie A. B. , Nortey Edith Shormey , Kangmennaa Ahmed , Forkuo Richard Baffour , Agorku Eric Selorm 
Published: January 2025

ABSTRACTMembrane technology is increasingly becoming a solution in wastewater treatment from textiles and dyeing, however, it has a continuing challenge on membrane fouling. In this study, we developed a series of hybrid activated clay (AC)/hydroxyapatite (HA)‐polyvinyl alcohol (PVA) composite membranes for fouling control during the removal of methylene blue (MB) dye from simulated wastewater. AC and HA, known for their dye‐sorption capabilities, were prepared in various ratios and incorporated as fillers in PVA to form composite membranes (PVA/AC/HA). Various characterization techniques including Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM) with energy dispersive x‐ray (EDX), zeta potential (ZP), and x‐ray diffraction (XRD) were used to analyze the structure, morphology and crystallinity of the fillers and membranes. The integration of AC and HA significantly influenced the structure, filtration performance, antifouling properties and hydrophilic nature of the membranes. Results indicated that the membrane with a 2:1 (AC: HA) ratio was most effective in MB removal. This membrane demonstrated optimal porosity and pure water flux (PWF) of 34.4% and 70.3 L/m2/h, respectively. Furthermore, it achieved a peak MB dye rejection rate of 95.5% and exhibited the highest flux recovery rate of 83.9%, highlighting its superior antifouling performance.
Stabilization of stochastic nonlinear systems with multiplicative state sensing noise
Authors: Kang Xiao‐Dong , Guo Bao‐Zhu 
Published: January 2025

AbstractIn this paper, we study the stabilization problem of stochastic nonlinear systems with multiplicative state noise. A key obstacle arises when sensor faults are contaminated by multiplicative white noise, rendering the measured values inherently nondifferentiable across various points. This significantly compounds the complexity of designing effective output feedback control. To address this, we propose a novel design approach for stochastic nonlinear systems, aiming to identify a series of control gains. Recognizing the limitations of the classical quadratic Lyapunov function in handling the stochastic terms of the system, we choose to employ a series of quartic Lyapunov functions for discussion. Utilizing the selected series of control gains, we achieve the mean‐square stability for the closed‐loop system and ensure the convergence of the control to zero under expectation. Finally, the effectiveness of the designed series of control gains is verified through numerical simulations of a Newtonian system and a robotic manipulator system driven by a permanent magnet DC motor.
Failure Mode and Degradation Analysis of a Commercial Sodium‐Ion Battery With Severe Gassing Issue
Authors: Klick Sebastian , Laufen Hendrik , Schütte Moritz , Qian Bowen , Quade Katharina Lilith , Rahe Christiane , Dubarry Matthieu , Sauer Dirk Uwe 
Published: January 2025

AbstractSodium‐ion batteries offer a promising alternative to lithium‐ion batteries by addressing ecological and economic challenges. However, to assess the applicability of these cells for different sectors, understanding aging behavior, including degradation modes, is crucial. This work presents a comprehensive aging analysis of 67 commercial sodium‐ion batteries under various temperatures, C‐rates, and depths of discharge. We analyzed the initial cell‐to‐cell variance and the aging trajectories regarding capacity fade and resistance increase. We demonstrated that the cycling rate does not significantly influence the aging trajectories, whereas smaller depths of discharge significantly reduce degradation. The degradation gradients for 25 °C and 40 °C were similar; for −10 °C, we observed rapid capacity fading that can be attributed to irreversible sodium plating. Furthermore, we identified the degradation modes for four different aging categories. Since some aging tests stopped due to gas‐induced current interrupt device triggering at low current rates and states of charge, we proposed two hypotheses for the gassing under specific conditions, suggesting inadequate gas consumption in cathode‐electrolyte side reactions or solid electrolyte interphase instability as potential causes. Overall, this work provides a valuable in‐depth analysis of the aging behavior of a commercial sodium‐ion battery as a function of temperature, C‐rate, and depth of discharge, with data made available for further research.
Long non‐coding RNA LINC01224 plays an oncogenic role in endometrial cancer via miR‐4673/TPX2 axis and activating Wnt/β‐catenin signaling pathway
Authors: Lv Shuqing , Zhang Xinlu , Lang Fangfang , Wu Yanmei , Zhang Cancan , Qi Qi , Jiang Jie 
Published: January 2025

AbstractEndometrial cancer (EC) is a prevalent gynecological malignancy with a rising incidence and poor prognosis in advanced cases. Long non‐coding RNAs (lncRNAs) have been implicated in various cancers, including EC. This study explores the role of lncRNA Linc01224 in EC. Analyzing TCGA data, we found Linc01224 expression significantly elevated in EC tissues, correlating with poor prognosis. Clinical samples validated these findings, showing higher Linc01224 levels in tumor tissues. Knockdown of Linc01224 in EC cell lines (Hec‐1‐B and Ishikawa) inhibited proliferation, migration, and promoted apoptosis, alongside increased Bax and decreased BCL2 expression. Furthermore, Linc01224 knockdown notably reduced Wnt2/β‐catenin pathway activation. We identified TPX2 as a target of miR‐4673, which is regulated by Linc01224 through a competing endogenous RNA (ceRNA) mechanism. Dual‐luciferase reporter assays confirmed miR‐4673 binding to Linc01224 and TPX2. Rescue experiments revealed that TPX2 knockdown reversed Linc01224‐induced proliferation and migration, highlighting TPX2's pivotal role in Linc01224's oncogenic function. In vivo, Linc01224 knockdown significantly impeded tumor growth and metastasis in a xenograft model, with decreased expression of c‐Myc, Cyclin D1, and β‐catenin. These findings reveal a novel ceRNA regulatory axis involving Linc01224, miR‐4673, and TPX2, elucidating Linc01224's role in EC progression through the Wnt2/β‐catenin pathway. Linc01224 emerges as a potential biomarker and therapeutic target for EC prognosis and treatment.