bluuebunny/crossref_metadata_2025_split huggingface dataset:
Progress of 3D Organoid Technology for Preclinical Investigations: Towards Human In Vitro Models
Authors: Liu Yingjuan , Xu Honglin , Abraham Sabu , Wang Xin , Keavney Bernard D. 
Published: December 2022

Review
Progress of 3D Organoid Technology for Preclinical Investigations: Towards Human In Vitro Models

Yingjuan Liu *, Honglin Xu, Sabu Abraham, Xin Wang, and Bernard D. Keavney*

Division of Cardiovascular Sciences, Faculty of Biology, Medicine and Health, University of Manchester, M13 9PT, UK.
* Correspondence: yingjuan.liu@manchester.ac.uk (Yingjuan Liu);
bernard.keavney@manchester.ac.uk (Bernard D. Keavney)

Received: 1 November 2022
Accepted: 24 November 2022
Published: 21 December 2022

Abstract: Currently, with an increased requirement for new therapeutic strategies, preclinical drug testing or screening platforms have rapidly evolved in recent years. In comparison to traditional 2D cell cultures, 3D organoids or spheroids with or without scaffolds improve the microenvironment of in vitro cultures, advancing the in vitro biological observation and enabling mechanistic studies of drug reactions in the human tissue-like environment. 3D organoids and spheroids are straightforward to produce, and relatively uniform in size and shape. This helps to facilitate high throughput screening requirements. Spheroids and organoids have been applied in anti-cancer drug testing, toxicity evaluations, as well as mechanism studies for variable organ systems, including the intestine, liver, pancreas, brain, and heart. Among 3D cultures of spheroids and organoids, ‘tumour spheroids’ formed by dissociated tumour tissues or cancer cell lines are relatively simple in composition and commonly applied to anticancer drug screening. The ‘healthy organoids’ differentiated from hiPSCs/hESCs are more complex in cell composition, distribution, structure and function with higher similarity to in vivo organs, and have found applications in toxicity tests, personalised medicine, and therapeutic and mechanistic studies. In most cases, the multicellular 3D organoids are more resistant and stable in reaction to stimulations or chemicals in vitro , suggesting more accurate modelling of in vivo responses. Here, we review recent progress in human-origin organoid/spheroid systems and their applications in preclinical studies.
The Hippo Signaling Pathway as a Drug Target in Familial Dilated Cardiomyopathy
Authors: Langa Paulina , Wolska Beata M. , Solaro R. John 
Published: December 2022

Review
The Hippo Signaling Pathway as a Drug Target in Familial Dilated Cardiomyopathy

Paulina Langa 1, Beata M. Wolska1,2, R. John Solaro1,*

1 Department of Physiology and Biophysics and the Center for Cardiovascular Research,University of Illinois at Chicago, Chicago, IL,USA.
2 Department of Medicine, Division of Cardiology, College of Medicine, University of Illinois at Chicago, Chicago, IL,USA.
* Correspondence: solarorj@uic.edu, Tel.: +1 (312)-420-0241, +1(312)-996-8546, Fax: +1 (312) 996-1414

Received: 1 November 2022
Accepted: 24 November 2022
Published: 21 December 2022

Abstract: We focus here on the Hippo pathway in the hierarchical sensing and modulation of the mechanical state of the adult heart in health and disease. The Hippo pathway interrogates the micro-environment of cardiac myocytes providing surveillance of the mechanical state with engagement of signaling pathways critical to homeostasis of cardiac development, remodeling, and function and vulnerable to pathologies. Our discussion centers on Hippo signaling in the altered mechanical state instigated by variants of genes expressing mutant sarcomere proteins that trigger a progression to dilated cardiomyopathy (familial DCM). There is an unmet need for therapies in DCM. Recent progress in the discovery of small molecules that target Hippo signaling and are intended for use in cardiac disorders provides leads for modifying Hippo in DCM. As we emphasize, identifying useful targets in DCM requires in depth understanding of cell specific Hippo signaling in the cardiac micro-environment.
Can AI See Bias in X-ray Images?
Authors: Szankin Maciej , Kwasniewska Alicja 
Published: December 2022

Article
Can AI See Bias in X-ray images?

Kwasniewska Alicja *, and Szankin Maciej *

1 SiMa Technologies Inc. 226 Airport Parkway, Suite 550 San Jose, CA 95110, United States
2 Intel Corporation 16409 W Bernardo Dr Suite 100, San Diego, CA 92127, United States
* Correspondence: alicja.kwasniewska@sima.ai; maciej.szankin@intel.com

Received: 8 November 2022
Accepted: 13 November 2022
Published: 22 December 2022

Abstract: Recent advances in artificial intelligence (AI) have shown promising results in various image-based systems, improving accuracy and throughput, while reducing latency. All these factors are crucial in healthcare and have generated increased interest in this technology. However, there are also multiple challenges integrating AI in existing systems, such as poor explainability, data imbalance and bias. These challenges affect the reliability of the neural networks used in AI applications. The limitations may significantly affect the quality and cost of medical care by introducing false positive diagnosis. The false positives subsequently lead to increased stress in patients and necessitate additional testing and procedures. Lack of rich data representing all socio-economic groups can also undermine reliable decisions for underrepresented groups. Although various studies discussed techniques that may help with bias mitigation, to the best of our knowledge, no practical experiments have been conducted so far that compare different reweighting approaches using convolutional neural networks (CNN). This work focuses on in-depth explanatory analysis of chest X-ray datasets to understand and quantify the problem of class imbalance and bias. After that, various topologies of binary classifications are compared, followed by practical applications of loss reweighting techniques and comparison of their influence of privileged, underprivileged, and overall population. Experiments proved that high classification accuracy can be achieved using an efficient model topology suitable for embedded devices, making it possible to run locally without the need for cloud processing. Preliminary results showed that performance of the model for the underprivileged class can be improved by 15% if proper weighting factors are obtained and applied during the training procedure.
Analysis and Visualization of Streaming Media Platforms Based on the R Language——Take Netflix as An Example
Authors: Gong Xiaoshi 
Published: December 2022

[Objective] This paper aims at finding the business content provided by Netflix through data analysis and discovering the conditions of the industry. [Methods] Netflix is selected as representatives of video platforms. R language is the core tool used for data analyzing to show various characteristics in content provision. [Results] Today's streaming media technology continues to develop rapidly, and many streaming media platforms focus on the richness of content. [Conclusion] Mastering the content of resources helps to achieve a more accurate recommendation, so as to retain users, and it can also be a reference for the development of streaming media in China.
Preface: 2022 International Conference on Media, Art, Management and Educational Engineering (MAMEE 2022)
Authors: Galsworthy Maria , Zhang Wen 
Published: December 2022

We are so delighted to announce that 2022 International Conference on Media, Art, Management and Educational Engineering (MAMEE 2022) was successfully held in Vienna, Austria during October 15-16, 2022. The conference aimed to provide a platform for interdisciplinary cooperation and communication for young scholars to lighten academic atmosphere, encourage innovation, create cooperation opportunities and boost young scholars' growth.
About 90 participants from academic, high-education institutes and other organizations took part in MAMEE 2022. The conference model was divided into two sessions, including oral presentations and keynote speeches. In the first part, some scholars, whose submissions were selected as the excellent papers, were given 10-15 minutes to perform their oral presentations one by one. Then in the second part, keynote speakers were each allocated 30-40 minutes to hold their speeches.
With the forum based on the display of the frontiers, we invited well-known experts and scholars at home and abroad as well as the outstanding youth to deliver academic reports. It is expected that MAMEE 2022 can provide a free academic atmosphere to encourage our distinguished guests to share their views, ignite new ways of thinking and harvest new ideas. This international academic conference aims to further promote exchanges and cooperation, to play an active role in improving academic standing and international influence in the areas of mass media, new media, art design, public art, management system, human resource management, distance education and educational engineering as well as shortening the gap with the top subject in the world.
MAMEE Organizing Committee
Vienna, Austria
The Recent Development of Blue LED
Authors: He Jingqian , Ma Muyan , Tang Zhenzhong , Wu Junchuan 
Published: December 2022

LED is a very influential light source for its high brightness, good color display and ability to modify the spectra. The performances of red LEDs and green LEDs have been greatly improved but the blue LEDs’ performance is still left behind. In this paper, researchers investigated the frontier research in recent years, including the progress and possible direction in conventional inorganic GaN blue LEDs, quantum dot blue LEDs, organic blue LED, and perovskite blue LED. The basic working principles of each direction are introduced first and the related characteristics of the materials and the luminance mechanisms are discussed. Then the authors analyze the key influencing factors in each of the above directions and compare the development status, LED performance parameters the stability, luminance efficiency and related advantages and disadvantages. Besides, brief history of the development will be introduced to get a full view of the changes in research idea in the past years. In each direction, a discussion is made with the focus on applications, further challenges, and the possible improvements and some suggestions and expectations of the blue LEDs are put forward.
Super high resolution numerical weather prediction model simulation of tiny anticyclones observed at the Hong Kong International Airport
Authors: Chan PW , HON KK , LI QS 
Published: December 2022

As a follow-up study of the observation of tiny anticyclones by short range LIDAR at the Hong Kong International Airport, super high model numerical weather prediction model simulation of the airflow is performed at a spatial resolution of 50 m. The simulation successfully captures the tiny anticyclonic flow, suggesting that such flow could partly arise from terrain effect on the airflow at the airport. The variability of the winds as observed by an anemometer and as forecast by the model compare well, suggesting that the simulations are realistic. Two case studies are considered. The results could be useful for reference by weather forecasters at the other airports in monitoring and studying terrain-disrupted airflow.
Effect of Counseling on Student Behavior in Preventing Caries of the Permanent First Molars at Hidayatullah Islamic Elementary School and Al-Fath Islamic Boarding School Kendari City
Authors: Erfiani Mery , Tasnim Tasnim , Sunarsih Sunarsih 
Published: December 2022

Introduction: Counseling is an educational activity carried out by giving messages, instilling confidence, so that people are not only aware, know and understand but are also willing and able to make recommendations that have to do with health. Health education is a combination of various activities and opportunities based on learning principles to achieve a situation where individuals, families, groups, or society as a whole want to live healthy, knowhow and do what can be done individually or in groups and receive help.
Method: This research is a quantitative research type with a pre-experimental design. This research will be carried out at Hidayatullah Islamic Elementary School and Al-Fath Islamic Boarding School Kendari City. The population is Hidayatullah Islamic Elementary School students, Kendari City, totaling 86 students and Pesantren Al-Fath Kendari totaling 58 students, so the population in this study was 144.
Result: The results of this study using Mann-Whitney test showed that the effect of counselingon student’s knowledge (p-value = 0,007< 0,05). The effect of counseling on student’s attitudes (p-value = 0,000< 0,05). The effect of counseling on student’s and actions (p-value = 0,020< 0,05).
Conclusion: There were differences effect of counseling using combination methods of lectures, discussions, practices, and role models on students' knowledge, attitudes, and actionsin preventing caries of the permanent first molars at Hidayatullah Islamic Elementary School Kendari.
Effect of Counseling on Changes in Attitudes and Actions in Containing Covid-19 Vaccination in the Elderly at Unaaha Health Center, Konawe Regency
Authors: Maulana Asrinda , Supodo Timbul , Sunarsih Sunarsih 
Published: December 2022

145

Introduction: Based on December 2021 data, the Public Health Center with the lowest COVID-19 vaccination coverage for the elderly was Unaaha Health Center which had a target of 2088 elderly people who had to be vaccinated with the coverage of the first dose of vaccination only 277 (16.1%) and the second dose of 119 vaccination (6,9%). This is what attracted researchers to conduct research on the Effect of Counseling on Changes in Attitudes and Actions in Conducting Covid-19 Vaccinations in the Elderly at the Unaaha Health Center, Konawe Regency.
Method: This type of research is Pre Experiment, the research design that will be used is One Group Pretest-Posttest Design.This research was conducted in the working area of the Unaaha Public Health Center, Konawe Regency, Southeast Sulawesi Province, carried out in March 2022. While the sample used was 92 respondents.
Result: Based on statistical tests, it is known that the exact sig (2-tailed) value shows a value of 0.000 <0.05 which means that there is a significant effect of counseling with the simulation method on changes in the attitude of the elderly and the exact sig (2-tailed) value shows a value of 0.000 <0.05 which means This means that there is a significant effect of counseling with the simulation method on changes in the actions of the elderly in carrying out Covid-19 vaccinations in the work area of the Unaaha Health Center.
Conclusion: There is a significant effect between counseling with the simulation method on changes in the attitudes and actions of the elderly in carrying out Covid-19 vaccinations in the work area of ​​the Unaaha Health Center.
Sistem Informasi Pengarsipan Surat Masuk dan Surat Keluar di Kementerian Agama Kota Padang
Authors: Wati Yetri Lina , Mary Thomson , Pratama Ade 
Published: December 2022

Kementerian Agama Kota Padang saat ini masih menggunakan cara manual dalam pengelolaan surat masuk dan surat keluar serta pembuatan laporan belum terkomputerisasi, sehingga memerlukan banyak waktu. Pemanfaatan sistem informasi bebasis web dapat dimanfaatkan untuk meminimalisir penggunaan waktu, karena sudah dilakukan secara terkomputerisasi. Penelitian ini bertujuan untuk Menghasilkan Sistem Informasi Pengarsipan Surat Masuk dan Surat Keluar dikementerian Agama Kota Padang dan membantu pendataan, penyediaan informasi sehingga proses kinerja di dapat meningkat dan lebih baik. Analisis dalam penelitian ini menggunakan konsep SDLC. Perancangan sistem dibuat dengan bahasa permodelan menggunakan UML. Sistem informasi pengarsipan surat masuk dan surat keluar dibuat menggunakan bahasa pemrograman PHP, menggunakan database MYSQL. Pegujian sistem mengunakan pengujian Alpha dan Beta, Untuk Pengujian Alpha yaitu Teknik Black Box Testing yang mana hasil pengujian Valid dan untuk pengujian beta sangat baik dengan rata-rata nilai 90,09%. Penelitian ini telah menghasilkan sebuah Sistem Informasi Pengarsipan Surat Masuk dan Surat Keluar di Kementerian Agama Kota Padang

Kata kunci: Pengarsipan, Sistem Informasi, Surat Masuk, Surat Keluar, SDLC
КОРРУПЦИОННЫЕ РИСКИ В СФЕРЕ ФИНАНСИРОВАНИЯ IT-РАЗРАБОТОК
Authors: Карипова Айнагуль , Бабашев Данияр , Беристенов Рауан 
Published: December 2022

Проанализированы расходы бюджетных средств на цифровизацию страны. За последние 8 лет (с момента создания учета данных об информсистемах govarch.kz) разработано 578 информсистем, на которые потрачено свыше 400 млрд тенге.
Отсутствие четкого понимания потребности в тех или иных информсистемах, непрозрачное ценообразование и закрытость процедур закупок стали причинами того, что треть из них признана невостребованной (178 из 578) и рекомендована к списанию.
Основная проблема связана с государственным планированием. В основу заложены формальные показатели, повлекшие финансирование проектов, не связанных с IT-отраслью.
Текущая регламентация закупа объекта интеллектуальной собственности привела к монополизации рынка.
Отечественный рынок разработчиков сконцентрирован в руках пяти квазигоскомпаний, которые получили более 50% денежных средств.
Заказчики квазигоссектора самостоятельно определяют стоимость IT-разработок, заключение уполномоченного органа для них не требуется. В итоге разница в цене на однотипные программы как внутри квазигоссектора, так в сравнении с госорганами достигает десятков млрд тенге.
При этом цифровизация не всегда дает должный экономический эффект.
Госсектор же для сокрытия завышения стоимости работ использует закрытый формат ДСП. Анализ показал, что при открытом закупе аналогичные работы стоят гораздо дешевле.
Действующая практика ценообразования и закупа работ по разработке информсистем, обусловленная высокой аффилированностью, порождает коррупционные риски завышения стоимости, несоответствия IT-продукта, приобретения существующих программ под видом новых разработок, ненужных или дублирующих систем.
CHOREOGRAPHER IN CONTEMPORARY THEATRE: THE CASE OF LATVIA
Authors: Jonīte Dita 
Published: December 2022

As the paradigm of dramatic theatre has changed and the genre of contemporary dance has evolved, a new approach to theatrical choreography has emerged. In Latvia, a new generation of contemporary dance choreographers has been active for two decades. They have significantly influenced both the aesthetics of their productions and developed the degree of the participation and co-responsibility in dramatic actors.
By working together with contemporary dance choreographers, some actors and directors have changed their attitudes toward their body, its role, and the meaning of their movements. There is a growing awareness of how much time, effort, and precision would be required for smart and valuable choreography. This is a new experience and an opportunity for dramatic theatre. To delve deeper, Ben Spatz, researcher and theorist of embodied practice, through his research encourages artists to focus on the process of exploring the body rather than endlessly developing technical virtuosity.
While the director is still primarily responsible for the staging, the work of the rest of the creative team is often of equal importance. According to the postdramatic theatre theory of German theatre scholar Hans-Thies Lehmann and the performing arts scholar Erika Fischer-Lichte, this is related to a general tendency in the contemporary theatre – the focus is set on living, immediate relationship between theatre and audience, and in this contemporary art discourse the choreographer plays a very important role.
FOUNDATION AND OPERATION OF THE ASSOCIATION OF LATVIAN TEXTILE ART (1994–2014)
Authors: Veilande-Apine Elīna 
Published: December 2022

Influenced by political and economic changes in Latvia in the mid-1990s of the 20th century artists in different fields of art came together and formed independent associations. Aija Baumane (1943–2019), artist and professor, the head of the Department of Textile Art at the Art Academy of Latvia (AAL), founded the Association of Latvian Textile Art (ALTA) together with ten textile artists from different generations.
The aim of the research: to describe the significance of the Association of Latvian Textile Art activities in first 20 years of operation and to identify changes in textile art since the 1990s. ALTA's attempt to motivate and encourage Latvian textile artists to become involved in world art processes marks a transition in various aspects. New ways for expression were searched and different understanding developed in textile art, and thus the question of the traditionally accepted function of textile work was raised. Until now the operation and significance of ALTA have not been studied, although its impact on the development of the textile art sector is undeniable.
The research is based on ALTA activity materials, mainly documented in the press - “Literatūra un Māksla”, “Māksla”, “Diena”, “Kultūras forums”, etc. as well as little studied and not systematized so far archive of the Association of Textile Art, located at the Department of Textile Art of the Art Academy of Latvia since the foundation of the association.
Encouraging Community Reading Interest through Digital Libraries in Karawang Regency
Authors: Nirmala Ine , Ilmi Nurul , Fahrullah  
Published: December 2022

Data from UNESCO shows that Indonesian people's interest in reading is only 0.001%, meaning that out of 1,000 Indonesians, only 1 person is an avid reader. This study aims to optimize the use of digital libraries, namely by making the community literate in technology and experiencing the various benefits of using digital libraries so that they can encourage people's interest in reading in Karawang Regency. We collect data by going directly to the community because we are literacy activists. The results of a survey in the community in Karawang Regency, from the age range of adolescents to adults, show that they have never visited the Regional Library of Karawang Regency. This implies that the interest in visiting the regional libraries to read books there is still low. This study aims to find out to what extent digital libraries can encourage people's interest in reading. In this digital age, people are more interested in holding gadgets than books. Recommendations for the Karawang Regional Library to be more aggressive in socializing digital libraries so that people can more easily access digital library services from their gadgets anytime and anywhere.
Feel the Rhythm of Korea: South Korea Nation Branding in Promoting Tourism Towards Indonesia
Authors: Jarlis Annisa , DJumala Darmansjah , Rezasyah Teuku 
Published: December 2022

The tourism sector for South Korea is playing important roles in supporting the country's economy. The South Korean Government pays special attention to the development and promotion of its country's tourism by forming a special organization, namely the Korea Tourism Organization (KTO). This study aims to determine the process of image building and promotion of South Korean tourism through descriptive qualitative analysis using the concept of nation branding. The data collection process was carried out through interviews with the KTO and also the Indonesian public who were the audiences of the 'Feel the Rhythm of Korea' campaign. This research shows that KTO has succeeded in identifying its market so that the implementation of nation branding is carried out efficiently through digital media and brings up elements of music and dance as unique selling points in its promotion. In addition, KTO has also succeeded in attracting public interest by using a nation-brand ambassador. The conclusion of this study is that KTO's innovation in using digital media to carry out nation branding and tourism promotion is the right decision, so that it succeeds in creating a positive image and encouraging the desire of the Indonesian public to travel to South Korea.