bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Construction of EU Normative Power and the Middle East ‘Conflict’ … 16 Years on
Authors: Pace Michelle 
Published: April 2023

AbstractIn this article, I revisit my 2007 piece on The Construction of EU Normative Power (NP) and the Middle East ‘conflict’ and bring in Manners' Arrival of NP in Planetary Politics' (NPA) frame to shed light on how the EU's southern neighbourhood and its social and political fragility becomes amplified by the ‘force multiplier’ of climate mitigation. For example, in 2018, Gaza sewage led to the closure of Israeli beaches and the shutdown of the desalination plant in Ashkelon, which supplies Israel with 15% of its drinking water. This is but one example of how Israel and Palestine are not only inter‐dependent but, perhaps more importantly, co‐dependent. This article therefore draws attention to the urgent need of thinking on the co‐constitution of all life on earth, particularly in a climate‐conflict scenario such as that of Israel and Palestine. Water scarcity, rising temperatures and electricity interruptions contribute to the region's instability. If policy‐makers from the region and beyond are to co‐ordinate policy interventions around water and food insecurity for instance, they cannot ignore intractable conflicts such as the Israeli–Palestinian issue and their ensuing implications for planetary politics. Such enduring ‘conflicts’ represent a microcosmic image of the planet as a whole. Along with the other contributions in this symposium, this piece invokes planetary politics as the space where we need – out of necessity – to think differently: Otherwise, others will be writing the script for us.
Effectiveness of mogamulizumab in patients with Mycosis Fungoides or Sézary syndrome: A multicentre, retrospective, real‐world French study
Authors: Beylot‐Barry M. , Quereux G. , Nardin C. , Duval‐Modeste A.‐B. , Dereure O. , Dalac‐Rat S. , Dobos G. , Pham‐Ledard A. , Ram‐Wolff C. , D'Incan M. , Grange F. , Braniste V. , Bagot M. 
Published: April 2023

AbstractBackgroundEfficacy and safety of mogamulizumab, a monoclonal antibody directed against C‐C chemokine receptor 4, were demonstrated in a previous multinational clinical trial conducted in patients with previously treated cutaneous T‐cell lymphoma (CTCL): Sézary syndrome (SS) or Mycosis Fungoides (MF).ObjectivesThe real‐world French OMEGA study aimed to describe effectiveness and tolerability of mogamulizumab in adult patients with CTCL, overall and according to the disease (SS or MF).MethodsIn this retrospective study, patients treated with mogamulizumab for SS or MF were included from 14 French expert centres. The overall response rate (ORR) under treatment was described (primary criterion), as well as treatment use and safety data.ResultsThe 122 analysed patients (69 SS, 53 MF) were aged 66.6 ± 12.1 years at mogamulizumab initiation, and their median disease duration was 2.5 years (IQR: 1.3–5.6). Prior to treatment start, they received a median of three systemic CTCL therapies (2–5). Overall, 77.8% of patients suffered from advanced disease (Stage IIB–IVB), with frequent blood (B1/B2) involvement (67.5%). Over the treatment period (median: 4.6 months, 2.1–7.2), 96.7% of patients received all the planned mogamulizumab infusions. Among the 109 patients evaluable for effectiveness, ORR was 58.7% (95% CI [48.9–68.1]) overall, 69.5% [56.1–80.8] in SS and 46.0% [31.8–60.7] in MF. Compartmental response in the blood was observed in 81.8% [69.1–90.9] of SS patients. Skin responses were observed in 57.0% [47.0–66.5] of patients overall, 66.7% [52.9–78.6] in SS and 46.0% [31.8–60.7] in MF. The most common serious adverse drug reactions were rash (8.1% of patients) and infusion‐related reactions (2.4%) which led to treatment discontinuation in 7.3% and 0.8% of patients, respectively. One patient with SS died from mogamulizumab‐related tumour lysis syndrome.ConclusionsThis large French study confirmed the effectiveness and tolerability of mogamulizumab in SS and MF patients in routine medical practice.
Efficacy of anti‐IL‐23 and anti‐IL‐17 after adalimumab failure in psoriatic patients
Authors: Mastorino L. , Susca S. , Cariti C. , Sliquini N. , Verrone A. , Stroppiana E. , Ortoncelli M. , Dapavo P. , Ribero S. , Quaglino P. 
Published: April 2023

AbstractBackgroundMany national guidelines at the European level recommend first‐line therapy based on the anti‐TNF‐alpha adalimumab for treatment of psoriasis and psoriatic arthritis, mainly for economic reasons. Consequently, patients being treated with newer IL‐17 and IL‐23 inhibitors underwent previous unsuccessful first‐line adalimumab‐based therapy.ObjectivesEvaluate the efficacy and safety of IL‐17 and IL‐23 inhibitors after treatment with adalimumab compared to adalimumab‐naive psoriatic patients.MethodsWe retrospectively analysed 1053 psoriatic patients treated with anti‐IL17 and anti‐IL23 agents, which included 68 and 24 adalimumab‐experienced and 399 and 260 bio‐naive patients. Efficacy was assessed with mean PASI, PASI90, PASI100, and <3.ResultsConcerning the achieving of PASI100, PASI90 and PASI < 3 in patients treated with anti‐IL17 agents, no significant differences were observed between adalimumab‐experienced and bio‐naive patients. In patients treated with an anti‐IL‐23 agent, a faster response was observed in bio‐naive patients, with PASI < 3 significantly higher than ADA‐experienced patients at 16 weeks (77% vs. 58% p = 0.048). In a sub‐analysis that evaluated the performance of anti‐IL17 and anti‐IL23 agents in adalimumab‐experienced patients with a history of secondary failure, no significant differences were found. In multivariate analysis of PASI100, only anti‐IL‐17 therapy appeared to have a negative impact at 52 weeks (OR: 0.54 p = 0.04) independently of previous treatment. For PASI90, type of treatment and bio‐naïve status did not seem to have an impact at any time point.ConclusionsAnti‐IL 23 and anti‐IL 17 agents are not significantly different in terms of efficacy in bio‐naive patients or as second‐line therapy after failure with a biosimilar or originator adalimumab.
Clinical and histopathological investigation of symmetrical alopecia with associated chronic pruritus in tufted capuchin monkeys (Sapajus apella apella)
Authors: Petak Ana , Boras Jadranko , Bata Ingeborg , Ilić Ivana , Hohšteter Marko , Šoštarić‐Zuckermann Ivan‐Conrado 
Published: April 2023

AbstractBackgroundSymmetrical alopecia is a common symptom of endocrine and autoimmune diseases, which are rarely manifested with pruritus. Increased levels of stress in primates have been presented with increased levels of pruritus and alopecia appearance.MethodsA pruritic and alopecic disease was investigated in a group of tufted capuchin monkeys (N = 12), but due to ethical reasons, four random animals were further investigated by numerous diagnostic methods. The impact of food and enclosure enrichment was assessed and observed over a 2‐year period.ResultsHistopathology of four random tufted capuchin monkeys revealed lymphocytic perifolliculitis, with an appearance of a “swarm of bees” which was suggestive of alopecia areata. Etiological classification of pruritus excluded dermatological, systemic, and neurological causes, making it behavioral. Enclosure and food enrichment had a beneficial impact on pruritus (12/12) and alopecia (10/12).ConclusionThe findings were suggestive of alopecia areata, while the pruritus was considered behavioral in origin. Alopecia and pruritus improved upon enclosure and food enrichment.
Evaluation of newborns with Down syndrome with weight less than 1500 g in the neonatal intensive care unit: A Japanese multicentre study
Authors: Ishida Shuji , Nakanishi Hidehiko , Kosaka Yukako , Yamaguchi Ayano , Ooka Mari ,   the Neonatal Research Network, Japan
Published: April 2023

AimThis study aimed to clarify the characteristics and their mortality‐related factors in very low birthweight infants with Down syndrome (DS) in Japan.MethodsThis retrospective case–control study enrolled newborns with DS weighing <1500 g admitted to neonatal intensive care unit (NICU) of the perinatal centre registered with the Neonatal Research Network of Japan (NRNJ) database from 2008 to 2019. The clinical characteristics and their mortality‐related factors were compared among the Dead group (newborns with DS who died in the NICU), the Survival group (newborns with DS who were alive from the NICU) and the Control group (newborns without congenital or chromosomal condition).ResultsA total of 53 656 newborns weighing <1500 g were registered in the NRNJ database for 12 years. Of these, 310 (0.6%) were diagnosed with DS: 62 newborns in the Dead group, 248 in the Survival group and 49 786 in the Control group without chromosomal condition. Logistic analysis revealed that there was a significant difference in the mortality‐related factors in congenital anomalies, pulmonary haemorrhage and persistent pulmonary hypertension of the newborn; the adjusted odds ratios were 8.6, 121 and 9.5, respectively. Newborns with DS weighing <1000 g showed the earliest death in the NICU on the Kaplan–Meier survival curve (P < 0.01).ConclusionThe mortality rate for newborns with DS weighing <1500 g was 20% (5% in the Control group). The mortality‐related factors were complications of congenital anomalies, pulmonary haemorrhage and persistent pulmonary hypertension of the newborn.
Spirituality, disability, and quality of life
Authors: Carter Erik W. 
Published: April 2023

AbstractPromoting the flourishing of people with intellectual and developmental disabilities (IDD) requires consideration of the same breadth of life domains that might matter to any other person. Like anyone else, many people with IDD (as well as their families) consider spirituality and religious participation to be central to their personal thriving. Yet, this dimension of their lives is often overlooked or ignored in the areas of assessment, planning, practice, and support. This article addresses the salience of spirituality and religion; their impact on QOL; the complexities of addressing these areas among people with IDD; the ways in which they can be conceptualized and assessed; and implications for policy and practice.
Association of poor sleep and HbA1c in metformin‐treated patients with type 2 diabetes: Findings from the UK Biobank cohort study
Authors: Xue Pei , Tan Xiao , Benedict Christian 
Published: April 2023

SummaryThe American Diabetes Association recommends a glycated haemoglobin target of less than 7% for treating type 2 diabetes mellitus. However, it is still being determined if poor sleep affects this therapeutic goal, despite being treated with the blood‐glucose‐lowering medication metformin. Thus, we used data from 5703 patients on metformin monotherapy participating in the UK Biobank baseline investigation between 2006 and 2010. We combined self‐reported chronotype, daily sleep duration, insomnia, daytime sleepiness and snoring into a multidimensional poor sleep score ranging from 0 to 5, with higher scores indicating a less healthy sleep pattern. With each point increase on the poor sleep score scale, the odds of patients having an glycated haemoglobin of ≥ 7% increased by 6% (odds ratio [95% confidence interval], 1.06 [1.01, 1.11], p = 0.021). When examining the components of the poor sleep score separately, snoring was specifically associated with a glycated haemoglobin of ≥ 7% (1.12 [1.01, 1.25] versus no snoring, p = 0.038). However, adjusting for health and lifestyle conditions, such as body mass index, weekly physical activity level and hypertension status, eliminated the significant associations between the poor sleep score and snoring with glycated haemoglobin of ≥ 7%. Our findings suggest that poor sleep, specifically snoring, a symptom of obstructive sleep apnea, may interfere with the therapeutic goal of achieving a glycated haemoglobin below 7%. However, other factors known to be promoted by poor sleep, such as high body mass index, low physical activity and hypertension, may also contribute to the link between poor sleep and higher glycated haemoglobin levels.
Beef and plant‐based burgers' mastication parameters depend on texture rather than on serving conditions
Authors: Ilic Jovan , Djekic Ilija , Tomasevic Igor , van den Berg Marco , Oosterlinck Filip 
Published: April 2023

AbstractPrevious studies dealing with plant‐based meat analogs confirmed the potential of oral processing methods to identify options for improving those products. Knowing that sensory perception can be influenced by adding condiments, this short communication aimed to investigate the texture and oral processing of four plant‐based burger analogs and a beef burger when consumed in portions or as part of model meals with buns and sides. Texture profile analysis indicated that beef burgers and analog E were the toughest. Two analogs (B and S) showed textures close to beef, while one (analog D) displayed significantly lower values for hardness, toughness, cohesiveness, and springiness. The instrumental data was only partly reflected in the mastication parameters. Adaptations in mastication behavior were expected, but differences between the plant‐based analogs were smaller than anticipated, although clear differences were observed for consumption time, number of chews and number of swallows. On the whole, mastication patterns concurred within different consumption scenarios (portions, model burgers), and significant correlations with instrumental texture were obtained.
A comparison of diet quality and cardiovascular and inflammatory responses between aerobically trained male adults following either a long‐term vegan or omnivorous dietary pattern
Authors: Craddock Joel C. , Probst Yasmine C. , Neale Elizabeth P. , Geraghty Nicholas , Peoples Gregory E. 
Published: April 2023

AbstractVegan dietary patterns are increasingly being adopted by endurance athletes, yet research examining the influence of this dietary pattern on exercise‐related physiology is limited. This pilot study, therefore, aimed to explore nutrient status, diet quality and cardiovascular and inflammatory responses in aerobically trained adult males following vegan and omnivorous dietary patterns during aerobic exercise. An incremental ramp running test was used to assess peak oxygen consumption (VO2peak) in males aged 18–55 years, engaging in >4 h training/week. Exercise testing was performed during walking and steady‐state running conditions (60% and 90% of VO2peak). Participants were grouped by dietary pattern type and were equivalent for age, training volume and VO2peak. When compared to the omnivorous group (n = 8, age 35.6 years, VO2peak 55.7 mL/kg/min), the vegan group (n = 12, age 33.4 years, VO2peak 56.4 m/kg/min) consumed more energy from carbohydrates (p = 0.007), and less energy from protein (p = 0.001) while exhibiting a higher overall diet quality score (p = 0.008). No differences in inflammatory biomarkers were observed before or after running. Total red blood cell count, haemoglobin and haematocrit levels were lower in the vegan dietary group. In summary, aerobically trained males, following a long‐term vegan diet, can tolerate a short bout of running broadly comparatively to their omnivore counterparts. More arduous endurance exercise conditions should be explored to further uncover potential outcomes of consuming a vegan dietary pattern and exercise‐related physiology.
Autoimmune encephalitis presenting with atypical parkinsonism: A case report and review of the literature
Authors: Ono Yoya , Higashida Kazuhiro , Takekoshi Akira , Kimura Akio , Shimohata Takayoshi 
Published: April 2023

AbstractAn 81‐year‐old man developed axial rigidity, bradykinesia, and cognitive impairment within 6 weeks. On initial examination, he was misdiagnosed with progressive supranuclear palsy (PSP). Brain magnetic resonance imaging showed hyperintensities in the bilateral mesial temporal lobes and basal ganglia. Neuronal antibodies previously reported in autoimmune encephalitis mimicking PSP were negative. Immunohistochemical and immunocytochemical analysis revealed the autoantibodies recognized neuronal surface and intracellular antigens. The diagnostic criteria for probable autoimmune encephalitis were fulfilled. We diagnosed him with autoimmune encephalitis. Intravenous immunoglobulin and steroid therapy improved his symptoms. The presence of novel autoantibodies causing autoimmune encephalitis presenting with atypical parkinsonism was suggested.
Acute fatty liver of pregnancy causing multiple organ dysfunction syndrome in a Chinese intensive care unit
Authors: Shen Yan , Wang Xujuan , Yao Yeying , Zhou Xingmei 
Published: April 2023

AbstractAcute fatty liver of pregnancy (AFLP) is a rare but severe condition associated with high rates of maternal and foetal morbidity and mortality. Timely discontinuation of pregnancy, professional supervision and appropriate management are helpful for a successful discharge. This article reports the presentation and nursing care of a pregnant woman who was diagnosed with AFLP and discharged from the intensive care unit (ICU) after a prolonged hospitalization. The patient was admitted to the ICU on the first day after a caesarean section, with deterioration of liver, kidney and coagulation function. On day 1 of ICU admission, she underwent transnasal high‐flow oxygen therapy. Owing to worsening respiratory status and oxygen saturation <85%, the patient was intubated on day 3 in the ICU. Her urine output decreased significantly, her bilirubin level progressively increased, and she was treated with bilirubin adsorption and haemodialysis. Multiple organ dysfunction syndrome occurred, along with many other complications, including subarachnoid haemorrhage and lower extremity venous thrombosis. The patient was finally extubated on day 7, and haemodialysis was discontinued on day 42, with a daily urine output of approximately 2000 mL. The patient was discharged from the ICU 43 days after admission. Treatment and care activities under qualified nursing care, including managing haemorrhage and anticoagulation in haemodialysis, pain care based on psychological support, early rehabilitation and nutrition and providing appropriate care for respiratory support, contributed to the successful discharge of the patient from the ICU. During the patient's 43‐day stay in the ICU, strict monitoring and personalized nursing care were implemented.
Lower tear meniscus height measured by optical coherence tomography in children
Authors: Martin‐García Beatriz , Palomo‐Álvarez Catalina , Piedrahita‐Alonso Elena , Gomez‐de‐Liaño Rosario , Ferrer Manuel Enrique Fuentes , Arriola‐Villalobos Pedro 
Published: April 2023

AbstractIntroductionWhile optical coherence tomography (OCT) measurements of the lower tear meniscus height (LTMH) have been reported in adults, here we obtained LTMH measurements through Fourier Domain OCT in healthy children and compared these with values obtained in healthy adults.MethodsParticipants were children 7–17 years of age and a control group of adults 20–40 years of age. Inclusion criteria were no abnormal eye conditions or the use of contact lenses. Candidates who fulfilled the TFOS DEWS II criteria for dry eye disease (DED) were excluded. All subjects underwent LTMH measurement (OCT Spectralis) and tests for non‐invasive tear break‐up time and ocular surface staining. Participants also completed the ocular surface disease index questionnaire.ResultsA total of 86 children and 27 adults were included. Mean LTMH values in the children and adult groups were 217.40 ± 71.40 μm and 225.0 ± 54.86 μm, respectively; p = 0.53. However, 59.3% of the children had an LTMH ≤210 μm suggestive of DED, compared with only 33.3% of adults (p = 0.02). For the children, no significant differences in LTMH were observed with sex or for those more or less than 12 years of age.ConclusionsOptical coherence tomography‐derived LTMH measurements were obtained in healthy children. While values were similar in children and adults, a greater proportion of children had an LTMH compatible with a diagnosis of DED. More studies in different paediatric populations are required to establish a complete set of normative LTMH measurements.
Hidradenitis suppurativa presenting as mammillary fistula in a teenage girl
Authors: Barker Catherine , Duff David , Wine Lee Lara 
Published: April 2023

AbstractHidradenitis suppurativa (HS) is a common skin disease in children and young adults. In this report, we describe an unusual case of HS presenting as a mammillary fistula (MF) in a teenage female. A thorough dermatologic history and exam resulted in diagnosis of HS. Identifying the underlying disease is key to appropriate treatment of a relapsing MF in the setting of HS.
The effects of sports‐related concussion history on female adolescent brain activity and connectivity for bilateral lower extremity knee motor control
Authors: Zuleger Taylor M. , Slutsky‐Ganesh Alexis B. , Anand Manish , Kim HoWon , Warren Shayla M. , Grooms Dustin R. , Barber Foss Kim D. , Riley Michael A. , Yuan Weihong , Gore Russell K. , Myer Gregory D. , Diekfuss Jed A. 
Published: April 2023

AbstractSports‐related concussions (SRCs) are associated with neuromuscular control deficits in athletes following return to play. However, the connection between SRC and potentially disrupted neural regulation of lower extremity motor control has not been investigated. The purpose of this study was to investigate brain activity and connectivity during a functional magnetic resonance imaging (fMRI) lower extremity motor control task (bilateral leg press) in female adolescent athletes with a history of SRC. Nineteen female adolescent athletes with a history of SRC and nineteen uninjured (without a history of SRC) age‐ and sport‐matched control athletes participated in this study. Athletes with a history of SRC exhibited less neural activity in the left inferior parietal lobule/supramarginal gyrus (IPL) during the bilateral leg press compared to matched controls. Based upon signal change detected in the brain activity analysis, a 6 mm region of interest (seed) was defined to perform secondary connectivity analyses using psychophysiological interaction (PPI) analyses. During the motor control task, the left IPL (seed) was significantly connected to the right posterior cingulate gyrus/precuneus cortex and right IPL for athletes with a history of SRC. The left IPL was significantly connected to the left primary motor cortex (M1) and primary somatosensory cortex (S1), right inferior temporal gyrus, and right S1 for matched controls. Altered neural activity in brain regions important for sensorimotor integration and motor attention, combined with unique connectivity to regions responsible for attentional, cognitive, and proprioceptive processing, indicate compensatory neural mechanisms may underlie the lingering neuromuscular control deficits associated with SRC.