bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between low eosinophil count and acute bacterial infection, a prospective study in hospitalized older adults
Authors: Mésinèle Léa , Pujol Tom , Brunetti Nicoletta , Neiss Marie , Trivalle Christophe , Souques Cecile , Houenou-Quenum Nadège , Verdier Sébastien , Simon Pauline , Vetillard Anne-Laure , Houdre Julie , Collarino Rocco , Mary Morgane , Vidal Jean-Sébastien , Kahn Jean-Emmanuel , Guichardon Magali , Duron Emmanuelle , Baudouin Edouard 
Published: August 2023

Abstract
BACKGROUND:
The incidence of severe sepsis increases significantly with age: less than 5/1000 when aged from 50 to 54 years old (y/o) vs more than 25/1000 when aged 85 y/o and older. Eosinopenia and the CIBLE score have been proposed in critically ill adults and in internal medicine wards. This study aimed to assess whether a low eosinophil count is associated with acute bacterial infection among a hospitalized older adults population, and to find the most efficient eosinophil count cut-off to differentiate acute bacterial infection from other inflammatory states.
METHODS:
This is a prospective study from July 2020 to July 2022 in geriatric wards of the University Paul Brousse Hospital (Villejuif, France) including patients aged ≥ 75 y/o suffering from fever or biological inflammation. Acute bacterial infection was assessed using the French Society of Infectious Diseases guidelines.
RESULTS:
A total of 156 patients were included. Eighty-two (53%) patients suffered from acute bacterial infection (mean age (SD) 88.7 (5.9)). Low eosinophil count was independently associated with acute bacterial infection: OR [CI95%] 3.03 [1.04 – 9.37] and 6.08 [2.42 – 16.5] for eosinophil count 0 – 0.07 G/L and 0.07 – 0.172 G/L respectively (vs eosinophil count > 0.172 G/L). Specificity and sensitivity for eosinophil count < 0.01 G/L and CIBLE score were 84%-49% and 72%-62%, respectively with equivalent AUCs (0.66 and 0.67).
CONCLUSION:
Eosinophil count < 0.01 G/L is a simple, routinely used and inexpensive tool which can easily participate in antibiotic decisions for older adults. Further studies are needed to assess clinical benefits.
Trial registration: The study was registered at Clinical trial.gov (NCT04363138 - 23/04/2020)
Should dolutegravir always be withheld in people with HIV on dolutegravir with incident diabetes mellitus? A case report
Authors: Mulindwa Frank , Castelnuovo Barbara , Brusselaers Nele , Bollinger Robert , Yendewa George , Amutuhaire Willington , Mukashaka Claudine , Schwarz Jean-Marc 
Published: August 2023

Abstract
Dolutegravir (DTG), an integrase strand transfer inhibitor is currently the recommended first and second line anti-retroviral therapy (ART) anchor agent by the World Health Organization. This followed widespread reports of primary resistance to non-nucleoside reverse transcriptase inhibitors. Despite its very good side effect profile, there have been multiple case reports of ART experienced patients developing hyperglycemia within weeks to a few months after switching to DTG preceded by weight loss. At population level, however, dolutegravir as well as other integrase inhibitors have been demonstrated to have a reduced risk of incident diabetes mellitus (T2DM) compared to other HIV drug classes. Following multiple similar reports of accelerated hyperglycemia in Uganda during the first pilot year of DTG use, the Uganda Ministry of Health recommended withholding dolutegravir in all patients who develop diabetes. Whether this recommendation should be applied to all patients with incident T2DM remains to be demonstrated. We present a clinical case of an HIV positive ART naïve man who was diagnosed with T2DM after 36 weeks on dolutegravir. We describe changes in blood glucose, glycated hemoglobin, insulin resistance and pancreatic beta cell function before and after withholding DTG. We demonstrated that he was phenotypically different from the reported cases of accelerated hyperglycemia and he continued to have worsening insulin resistance despite withholding DTG. His blood glucose improved with dietary T2DM management. It is possible he had an inherent risk of developing T2DM independent of his exposure to DTG. This put in question whether DTG should universally be withheld in PLHIV with incident T2DM in Uganda.
Research on the Integral Forming Process of Thin walled and Thick Mouth Seamless Gas Cylinders
Authors: Wang Chen , Yu Haofei , Tian Wang , Zhao Chunjiang , Jiang Lianyun , Bai Qiaofeng 
Published: August 2023

Abstract
There is a considerable difference in wall thickness between the mouth and the cavity of thin-walled and thick-mouthed seamless gas cylinders, and the existing manufacturing processes are unable to effectively meet product requirements. To overcome such issue, a step-by-step boring-necking-spinning solution for gas cylinders was proposed, in which sufficient wall thickness is reserved for the mouth area of the cylinder blank, followed by necking-spinning to realize the overall forming of thin-walled, thick-mouthed seamless gas cylinders. The stress-strain distribution and geometric dimensional changes of gas cylinders during the spinning process were investigated by means of finite element simulation, and the effects of different process parameters on the stress and wall thickness of the bottle mouth were analyzed. Further, multi-objective optimization of the response surface model was performed using the NSGA-II algorithm to derive a set of optimal process parameters. Finally, the correctness of the simulation and optimization results was verified experimentally, and the expected geometry and optimal strain state of the gas cylinder were obtained. The newly developed processing solution represents a groundbreaking advancement in the manufacturing of thin-walled and thick-mouthed gas cylinders.
Plasma water T2 detects age-stratified differences in cardiometabolic health among familial CCM patients with Hispanic CCM1 mutation
Authors: Croft Jacob , Sandoval Diana F. , Cistola David , Zhang Jun 
Published: August 2023

Abstract

Introduction. Cerebral cavernous malformations (CCMs) are abnormal clusters of capillaries in the nervous system. This pilot study analyzed the cardiometabolic health status of individuals with familial CCMs caused by a rare mutation in the CCM1 gene (fCCM1). The aim was to compare plasma water T2 values from individuals with fCCM1 with values from metabolically unhealthy and healthy individuals with no known CCM mutations.
Design. This observational, cross-sectional study included 75 participants: 11 fCCM1 patients, 24 metabolically unhealthy and 40 metabolically healthy individuals. Plasma water T2, an early, global and practical marker of cardiometabolic health, was measured in the time domain using benchtop magnetic resonance relaxometry. The results were stratified by age (equal to or less than 45 vs. older than 45 years). Group means were compared using Welch’s one-way ANOVA and post hoc Tukey-Kramer tests. Multivariable linear regression, with T2 as the outcome variable, was used to explore associations with age, gender, Hispanic ethnicity and fCCM1 status.
Results. In the younger age stratum, the fCCM1 group had a mean plasma water T2 value comparable to the metabolically healthy group (p=0.6388), but higher than the unhealthy group (p<0.0001). By contrast, in the older stratum, the mean plasma water T2 value for the fCCM1 group was comparable to the metabolically unhealthy group (p=0.7819) and lower than the healthy group (p=0.0005). Multivariable linear regression revealed that age and the interaction between age and fCCM1 status were significant predictors of T2, even after adjusting for gender and Hispanic ethnicity.
Conclusion. Plasma water T2 shows potential as a biomarker for assessing the health status of individuals with fCCM1. Further research is needed to validate these preliminary observations and elucidate the association between CCMs and cardiometabolic health.
On string algebras and the Cohen-Macaulay Auslander algebras
Authors: Zhang Chao , Liu Yu-Zhe 
Published: August 2023

Abstract
The Cohen-Macaulay Auslander algebra of an algebra $A$ is defined as the endomorphism algebra of the direct sum of all indecomposable Gorenstein projective $A$-modules. The Cohen-Macaulay Auslander algebra of any string algebra is explicitly constructed in this paper.% and describe some properties of a class of special string algebras by their Cohen-Macaulay Auslander algebras. Moreover, it is shown that a class of special string algebras, which are called to be string algebras with {\it G-condition}, are representation-finite if and only if their Cohen-Macaulay Auslander algebras are representation-finite. As applications, the derived discreteness and some homological dimension of gentle algebras are described in terms of their Cohen-Macaulay Auslander algebras.
MSC2020: 16G10, 16G70, 16P10.
Sustainable Sythesis of Eco-friendly Yogurt From Fruit Waste
Authors: Majeed Hammad , Iftikhar Tehreema , Javaid Aqsa 
Published: August 2023

Abstract
Agricultural waste is not only contributing to landfills but also generating significant amounts of greenhouse gases (GHGs), thereby increasing carbon footprints. The key solution to address climate change lies in adopting sustainable practices across all research fields. Our current study is innovative, as it involves utilizing fruit waste for green synthesis to produce zinc nanoparticles and formulate a fortified yogurt, aiming to combat zinc deficiency, especially prevalent in developing countries.
The synthesis of zinc nanoparticles with an average diameter of 71nm was achieved using Citrus sinensis peel extract, which effectively reduced zinc ions. To fortify yogurt, zinc was added to pasteurized milk at 50% of its recommended dietary allowance and incubated at 37°C for 5 hours. Subsequently, we conducted sensory, physical, antibacterial, and rheological analyses to assess the impact of zinc fortification on various yogurt properties. The antibacterial analysis revealed that zinc-fortified yogurt exhibited increased antibacterial activity. The sensory evaluation indicated that the fortified samples received higher scores compared to the control. Fortification did not significantly affect the moisture content, ash content, acidity, pH, and density of yogurt. Over the 14 days storage period, all samples experienced a slight decrease in moisture content, while ash content increased. The pH exhibited an inverse relationship with storage time, whereas titratable acidity displayed the opposite trend. The density of yogurt samples remained unaffected by fortification or storage time. Zinc-fortified yogurt demonstrated reduced syneresis due to the efficient binding of zinc nanoparticles with casein micelles, resulting in stabilized yogurt gel. Rheological analysis showed that the apparent viscosity of all samples increased during the 14-day storage period. However, freshly prepared fortified samples exhibited higher initial viscosity and slower viscosity increases compared to the control.
DNA Bar-coding of Blue Whale Balaenoptera musculus (Linnaeus, 1758) (Mammalia: Cetacea: Balaenopteridae) stranded at Mandarmani beach, West Bengal, India
Authors: Balakrishnan S. , Tudu P. C. , Acharya Smrutirekha , Mohapatra Anil , Raghunathan C 
Published: August 2023

Abstract
The present paper reports the molecular analysis (CoI) of a female blue whale Balaenoptera musculus (Linnaeus, 1758) of approximately 40 ft in length, stranded on June 29, 2020 at Mandarmani along the West Bengal coast. This is the second record of stranding of blue whale along the coast after 1934. The strandings provides vital information on species life histories, population health and status of marine ecosystems. Since all cetaceans are important from a conservation perspective; precise documentation of their occurrence would provide valuable information about the distribution and migratory nature of different species in the seas around India. A table of blue whales stranded on Indian coasts between 1874 and 2020 has been provided.
Solid waste management in the fast-food restaurant industry: The antecedent role of institutional isomorphism
Authors: Mukucha Paul , Jaravaza Divaries Cosmas , Tshuma Ethel Mathonsi , Dangaiso Phillip , Jaravaza Nomuhle , Chingwaru Trymore , Risiro Joshua 
Published: August 2023

Abstract

The study conceptually suggested isomorphic pressures as the drivers of sustainable food waste disposal management, and operational performance as an attendant outcome. 400 fast-food restaurant businesses in the metropolitan city of Harare were surveyed using a self-administered questionnaire whose items were distilled from the extant literature. Data analysis was conducted using Structural Equation Modelling (SEM) on an Analysis of Moment Structures (AMOS). The results indicated that the three isomorphic pressures (cohesive, mimetic, and normative) have statistically significant influence on the adoption of sustainable food waste disposal management practices and in turn the same practices lead to profitable operations. The study therefore concluded that the three variants of isomorphic pressure and profitability act as the push and pull strategies for the adoption of sustainable food waste disposal management practices respectively. In terms of policy implications, the study recommended the reinvigoration of various isomorphic pressures related to the food waste disposal management.
CircGLIS3 promotes gastric cancer progression by regulating the miR-1343-3p/PGK1 pathway and inhibiting vimentin phosphorylation
Authors: Zhang Yongxin , Wang Xiaofeng , Liu Wenwei , Lei Tianxiang , Tang Qiao , Feng Wei , Song Wu 
Published: August 2023

Abstract
Background
Circular RNAs (circRNAs) have been proved to play crucial roles in the development of various cancers. However, the molecular mechanism of circGLIS3 involved in gastric cancer (GC) tumorigenesis has not been elucidated.
Methods
The higher expression level of circGLIS3 was identified in GC through RNA sequencing and subsequent tissue verification using Quantitative real-time PCR (qRT-PCR). A series of functional experiments in vitro and in vivo were performed to evaluated the effects of circGLIS3 on tumor growth and metastasis in GC. The interaction and regulation of circGLIS3/miR-1343-3p/PGK1 axis was confirmed by RNA pulldown, western blot, and rescue experiments. RIP and western blot were performed to demonstrate the role of circGLIS3 in regulating phosphorylation of VIMENTIN. We then used qRT-PCR and co culture system to trace circGLIS3 transmission via exosomal communication and identify the effect of exosomal circGLIS3 on gastric cancer and macrophages. Finally, RIP experiments were used to determine that EIF4A3 regulates circGLIS3 expression.
Results
CircGLIS3(hsa_circ_0002874) was significantly upregulated in GC tissues and high circGLIS3 expression was associated with advanced TNM stage and lymph node metastasis in GC patients. We discovered that overexpression of circGLIS3 promoted GC cell proliferation, migration, invasion in vitro and in vivo, while suppression of circGLIS3 exhibited the opposite effect. Mechanistically, circGLIS3 could sponge miR-1343-3p and up-regulate the expression of PGK1 to promote GC tumorigenesis. We also found that circGLIS3 reduced the phosphorylation of VIMENTIN at ser 83 site by binding with VIMENTIN. Moreover, it was proven that exosomal circGLIS3 could promote gastric cancer metastasis and the M2 type polarization of macrophages. In the final step, the mechanism of EIF4A3 regulating the generation of circGLIS3 was determined.
Conclusion
Our findings demonstrate that circGLIS3 promotes GC progression through sponging miR-1343-3p and regulating VIMENTIN phosphorylation. CircGLIS3 is a potential therapeutic target for GC patients.
Developing a Method for Training Clinical Psychologists to Recognize and Repair Alliance Ruptures: A Pilot Study
Authors: Kawamura Asaka , Fukuda Mina , Aoki Shuntaro , Jinnai Ayane 
Published: August 2023

Abstract
Background
Research in psychotherapy has underscored the importance of therapeutic relationships, especially alliances between therapists and clients, in predicting therapeutic outcomes. A strong alliance not only enhances outcomes, but also reduces client dropout rates. Ensuring therapists' self-awareness, emotional regulation, and insightful analysis of their interactions with clients are pivotal for maintaining this alliance and addressing potential ruptures.
Methods
A training program was formulated with three primary components: 1) observation of one's thoughts, feelings, and intentional behavioral control; 2) mindfulness training; and 3) consideration and categorization of the triadic adjacencies of interactions during therapy sessions. To assess the program's effectiveness, a pilot study was conducted with graduate students.
Results
Content analysis post training showed a notable reduction in respondents who felt "hooked" (Pre1 65%, Pre2 50%, Post 17%) and a significant increase in those who felt "involved well" (Pre1 22%, Pre2 36%, Post 83%). Post-training feedback revealed that the most frequent positive responses were "noticing captivity objectively" (24%), "relating with intention" (21%), and "not being upset" (14%). Although the first two components of the program were deemed effective, the third component concerning triadic adjacencies requires further refinement.
Conclusion
The training program showed promise for promoting therapist awareness and preventing alliance ruptures. However, refinements are necessary, particularly for the triadic adjacency component. The study's limitations include not objectively measuring awareness frequency and the potential influence of social desirability bias in participants' feedback.
Study on Instability Mechanism of Soft Rock Roadway and Pressure-relief Bolt-grouting Support Technology
Authors: Yang Tuo , Liu Jianzhuang , Luo Jianqiao , Shen Yupeng , Fu Peng 
Published: August 2023

Abstract
Aiming at the engineering problem of roadway deformation and instability of expansive soft rock widely existed in Kailuan mining area, the mineral composition and microstructure of such soft rock were obtained by conducting scanning electron microscopy, X-ray diffraction experiments, uniaxial and conventional triaxial tests, etc., and the law of softening and expanding of such soft rock and the failure mechanism of surrounding rock were identified. The combined support scheme of multi-level anchor bolt, bottom corner pressure relief and fractional grouting is proposed. The tunnel supporting parameters are adjusted and optimized by FLAC3D numerical simulation, and three supporting methods of multi-layer anchor bolt, bottom corner pressure relief and fractional grouting are determined and their parameters are optimized.
The study results show that:
1) The total amount of clay minerals is 53%~75%, and pores, fissures, nanoscale and micron layer gaps are developed, providing a penetrating channel for water infiltration to soften the surrounding rock；
2) The three-level anchor pressure-relief and grouting support technology can control the sinking amount of the roof within 170mm, the bottom drum amount within 210mm, the bolts of each level is evenly distributed in tension, and the maximum stress and bottom drum displacement in the pressure relief area are significantly reduced;
3) The pressure-relief groove promotes the development of bottom corner cracks, accelerates the secondary distribution of peripheral stress, and weakens the effect of high stress on the shallow area. Using time or displacement as the index, optimizing the grouting time, filling the primary and excavation cracks, blocking the expansion and softening effect of water on the rock mass, realizing the dynamic unity of structural yielding pressure and surrounding rock modification, has guiding significance for the support control of soft rock roadway.
Research on the online evaluation of the straightness error of hydrostatic guideways based on deep learning
Authors: Wang Zhiwei , Jia Yanhao , FU Penghao , Li Haiyin , Song Li , Yang Bingqing , Zhang Lijun , Yuan Liang , Shi Kan 
Published: August 2023

Abstract

Currently, the measurement of guide rail straightness error is basically a direct measurement, which cannot meet the requirements of online straightness error measurement in the machining process of the machine tool. Therefore, this paper proposes a straightness error evaluation model based on the recess pressure, which can realize the online measurement of the straightness error of hydrostatic guideways. To address the nonlinear relationship between the recess pressure and the linear deviation data of the guideway in an experiment, based on deep learning, the hydrostatic guideway straightness error was evaluated. First, the experimental data are analyzed and processed by feature, and a sliding window is processed using the data time sequence. Second, a long short-term memory network model is constructed based on an attention mechanism, the model parameters are obtained through orthogonal experiments, and the theoretical straightness error of the hydrostatic guideway is obtained via training. Finally, the theoretical values of the model and the experimental values of straightness error are compared and evaluated. The results show that the model can effectively evaluate the straightness error of hydrostatic guideways.
Modified gradient-based algorithm to find Hamiltonian solution to the Sylvester conjugate transpose matrix equation
Authors: BAYOUMI AHMED 
Published: August 2023

AbstractThis paper discussed a modified gradient-based iterative (MGI) algorithm for solving the Sylvester conjugate transpose matrix problem over the Hamiltonian matrix. We proved that the suggested algorithm converges to the exact solution for every given initial Hamiltonian matrix. A sufficient condition is specified to assure that the suggested algorithm's solution converges to the Hamiltonian solution. Numerical examples are presented to verify the theoretical conclusions and illustrate the superiority and efficiency of the offered approach over the relaxed gradient-iterative (RGI) algorithm proposed in [13].