bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adaptive responses of cardiorespiratory system and hormonal parameters to individualized high-intensity interval training using anaerobic power reserve in well-trained rowers
Authors: Wang Xiaodong , Zhao Liqiu 
Published: April 2023

The current study investigated the efficacy of individualizing exercise intensity according to anaerobic power reserve (APR) on hormonal, physiological, and performance adaptations in athletes with different profiles. Sixteen highly-trained male rowers (age = 22 ± 3 years, height = 183 ± 6 cm, weight = 83 ± 7 kg, body fat = 11 ± 2%, experience = 12 ± 5 years) were randomized to a high-intensity interval training consisting of 2 × (6, 6, 8, 8, 10, 10 repetitions from 1st to 6th week, respectively) × 60 s intervals using a rowing ergometer at ∆%30 APR (APR∆%30) or the same sets and repetitions at 130% maximal aerobic power (MAP130%). In both groups, relief intervals were set at 1:1 with 3 min of rest between sets. On four occasions separated by 24 h recovery, participants attended the laboratory to assess 2000-m rowing ergometer performance, maximal oxygen uptake (V̇O2max) and related physiological adaptations, and hormonal parameters. Significant increases were observed in 2000-m performance, V̇O2max, ventilation at V̇O2max, first and second ventilatory threshold, MAP and maximal sprinting power (MSP), total testosterone, and testosterone to cortisol ratio in response to 6 weeks of APR∆%30 and MAP130% protocols. The coefficient of variation (inter-subject variability) in the adaptive response of cardiorespiratory parameters to HIIT performed using the APR∆%30 protocol was lower than those of the MAP130% group. However, this is not the case for hormonal changes. Prescribing HIIT based on an athlete’s APR may help to create a more consistent level of the mechanical and physiological stimulus relative to the athlete’s capacity, potentially leading to more similar adaptations across athletes with varying profiles. Mechanisms influencing total testosterone are multifactorial and are not affected by this approach.
Reliability and validity of the positive mental health literacy scale in Chinese adolescents
Authors: Liu Zhanfang , Yuan Fangru , Zhao Jin , Du Jianzheng 
Published: April 2023

Background and aimMental health literacy (MHL) is not only the necessary knowledge and ability to promote mental health, but also an important determinant of mental health. Traditionally, the MHL Scale focuses on measuring knowledge and beliefs about mental disorders. In China, there are very few scales for assessing positive MHL. The present study aimed to evaluate the reliability and validity of a Chinese version of the Positive MHL Scale (MHPK-10) in Chinese adolescents.MethodsChinese adolescents (n = 1,247) completed the MHPK-10 online. The validation included the translation and cultural adaptation of the MHPK-10 original version into Chinese and assessment of its psychometric properties: reliability—test–retest and internal consistency, construct validity and criterion validity.ResultsParticipant’s mean score on the revised positive MHL scale was 3.75 (SD = 0.69) which was a unidimensional scale. The correlation coefficients between each item and the total score were between 0.639 and 0.753. Scale item loadings ranged between 0.635 and 0.760 based on confirmatory factor analysis. Cronbach’s α coefficient of the scale was 0.869, and the test–retest intraclass correlation coefficient was 0.721 (p &lt; 0.01). Criterion validity was assessed by comparing results of the revised MHPK-10 against those of other validated scales and resulting correlations ranged between 0.342 and 0.615.ConclusionThe revised Chinese version of the MHPK-10 has sound reliability and validity and can be used to measure Chinese adolescents’ positive MHL.
Depression and quality of life among Macau residents in the 2022 COVID-19 pandemic wave from the perspective of network analysis
Authors: Si Tong Leong , Chen Pan , Zhang Ling , Sha Sha , Lam Mei Ieng , Lok Ka-In , Chow Ines Hang Iao , Li Jia-Xin , Wang Yue-Ying , Su Zhaohui , Cheung Teris , Ungvari Gabor S. , Ng Chee H. , Feng Yuan , Xiang Yu-Tao 
Published: April 2023

BackgroundIn the summer of 2022, Macau experienced a surge of COVID-19 infections (the 618 COVID-19 wave), which had serious effects on mental health and quality of life (QoL). However, there is scant research on mental health problems and QoL among Macau residents during the 618 COVID-19 wave. This study examined the network structure of depressive symptoms (hereafter depression), and the interconnection between different depressive symptoms and QoL among Macau residents during this period.MethodA cross-sectional study was conducted between 26th July and 9th September 2022. Depressive symptoms were measured with the 9-item Patient Health Questionnaire (PHQ-9), while the global QoL was measured with the two items of the World Health Organization Quality of Life-brief version (WHOQOL-BREF). Correlates of depression were explored using univariate and multivariate analyses. The association between depression and QoL was investigated using analysis of covariance (ANCOVA). Network analysis was used to evaluate the structure of depression. The centrality index “Expected Influence” (EI) was used to identify the most central symptoms and the flow function was used to identify depressive symptoms that had a direct bearing on QoL.ResultsA total 1,008 participants were included in this study. The overall prevalence of depression was 62.5% (n = 630; 95% CI = 60.00–65.00%). Having depression was significantly associated with younger age (OR = 0.970; p &lt; 0.001), anxiety (OR = 1.515; p &lt; 0.001), fatigue (OR = 1.338; p &lt; 0.001), and economic loss (OR = 1.933; p = 0.026). Participants with depression had lower QoL F (1, 1,008) =5.538, p = 0.019). The most central symptoms included PHQ2 (“Sad Mood”) (EI: 1.044), PHQ4 (“Fatigue”) (EI: 1.016), and PHQ6 (“Guilt”) (EI: 0.975) in the depression network model, while PHQ4 (“Fatigue”), PHQ9 (“Suicide”), and PHQ6 (“Guilt”) had strong negative associations with QoL.ConclusionDepression was common among Macao residents during the 618 COVID-19 wave. Given the negative impact of depression on QoL, interventions targeting central symptoms identified in the network model (e.g., cognitive behavioral therapy) should be developed and implemented for Macau residents with depression.
Challenges of having a child with congenital anomalies in Saudi Arabia: a qualitative exploration of mothers' experience
Authors: Alqarawi Nada , Alhamidi Sami Abdulrahman , Alsadoun Ahmed , Alasqah Ibrahim , Mahmud Ilias 
Published: April 2023

BackgroundCongenital anomalies in children lead to morbidity, mortality, or lifelong disabilities. Mothers of children with congenital anomalies face considerable obstacles in parenting their children because of their lack of knowledge about such health conditions, lack of family support, and lack of health, rehabilitation, and social care support. In Saudi Arabia, less attention are given to researching this important issue. In this context, the purpose of the study was to explore mothers' experiences and perceptions toward children with congenital anomalies.MethodsWe employed a qualitative phenomenological study design. We purposively recruited 10 mothers of children with congenital anomalies from different cities in Saudi Arabia. We interviewed the mothers with an in-depth interview guideline. The interview questions were designed to explore their perception of congenital anomalies in children and their experience of parenting and seeking health, rehabilitation, education, and social care services for children with such anomalies.ResultAnalysis of our data suggest that mothers of children with congenital anomalies face considerable challenges because of a lack of medical, rehabilitation, and social care support, lack of knowledge about these conditions and their management, lack of responsiveness of the healthcare providers, lack of support from the family and the stigma associated with such conditions. Consequently, mothers experience poor mental and social well-being.ConclusionMothers are facing considerable challenges in raising children with congenital anomalies. Regular screening for early detection of congenital anomalies, counseling support for mothers, and improving healthcare providers' responsiveness, knowledge, and skills are necessary. In addition, appropriate awareness-raising programs need to be implemented at the community level to counteract the stigma and negative attitudes of the community toward children with congenital anomalies and their families.
Microarray patch for HIV prevention and as a multipurpose prevention technology to prevent HIV and unplanned pregnancy: an assessment of potential acceptability, usability, and programmatic fit in Kenya
Authors: Gachigua Sammy Gakero , Karuga Robinson , Ngunjiri Anne , Jarrahian Courtney , Coffey Patricia S. , Kilbourne-Brook Maggie , Otiso Lilian 
Published: April 2023

BackgroundMicroarray patches (MAPs), a novel drug delivery system, are being developed for HIV pre-exposure prophylaxis (PrEP) delivery and as a multipurpose prevention technology (MPT) to protect from both HIV and unintended pregnancy. Prevention technologies must meet the needs of target audiences, be acceptable, easy to use, and fit health system requirements.MethodologyWe explored perceptions about MAP technology and assessed usability, hypothetical acceptability, and potential programmatic fit of MAP prototypes using focus group discussions (FGD), usability exercises, and key informant interviews (KII) among key populations in Kiambu County, Kenya. Adolescent girls and young women (AGYW), female sex workers (FSW), and men who have sex with men (MSM) assessed the usability and acceptability of a MAP prototype. Male partners of AGYW/FSW assessed MAP acceptability as partners of likely users. We analyzed data using NVivo, applying an inductive approach. Health service providers and policymakers assessed programmatic fit. Usability exercise participants applied a no-drug, no-microneedle MAP prototype and assessed MAP features.ResultsWe implemented 10 FGD (4 AGYW; 2 FSW; 2 MSM; 2 male partners); 47 mock use exercises (19 AGYW; 9 FSW; 8 MSM; 11 HSP); and 6 policymaker KII. Participants reported high interest in MAPs due to discreet and easy use, long-term protection, and potential for self-administration. MAP size and duration of protection were key characteristics influencing acceptability. Most AGYW preferred the MPT MAP over an HIV PrEP-only MAP. FSW saw value in both MAP indications and voiced need for MPTs that protect from other infections. Preferred duration of protection was 1–3 months. Some participants would accept a larger MAP if it provided longer protection. Participants suggested revisions to the feedback indicator to improve confidence. Policymakers described the MPT MAP as “killing two birds with one stone,” in addressing AGYW needs for both HIV protection and contraception. An MPT MAP is aligned with Kenya's policy of integrating health care programs.ConclusionsMAPs for HIV PrEP and as an MPT both were acceptable across participant groups. Some groups valued an MPT MAP over an HIV PrEP MAP. Prototype refinements will improve usability and confidence.
Palmitic acid-modified GnRH-Th epitope peptide immunocastration vaccine (W/O/W adjuvant) can effectively ensure the castration and reduce the smelly smell in boars
Authors: Gao Huayi , Liu Kun , Zhang Lu , Wang Yongfang , Fu Xubin , Guo Yujie , Bai Mei , Shen Yanbing , Wang Min 
Published: April 2023

IntroductionRecent studies have demonstrated the effectiveness of Gonadotropin-releasing hormone (GnRH) in inhibiting testicular growth and development in male animals to achieve castration while improving the meat quality of various livestock species, including cattle, sheep, goats, and pigs.MethodsIn this research, a GnRH-Th vaccine was synthesized using the Fmoc solid-phase synthesis technique, and the T helper (Th) antigen was modified with palmitic acid to improve its efficacy. The vaccine was then coated with a water-in-oil-in-water adjuvant to improve stability and safety. After passing safety and stability tests, the vaccine was administered to 13-week-old boars.ResultsThe results showed that it was stable, safe, and effective for up to 15 months. Moreover, the vaccine did not negatively affect the growth rate and body weight of the pigs. The palmitic acid-modified “GnRH-Th epitope peptide immunocastration vaccine (Water-in-Oil-in-Water (W/O/W)) effectively reduced the testosterone concentration and achieved castration. The concentration of androstenone and skatole hormones significantly decreased, leading to improved meat quality in the boars. The boars were then slaughtered at 33 weeks of age, and the results showed that the meat quality of the vaccinated boars was superior to that of the non-vaccinated control group (p &lt; 0.05).DiscussionThis study demonstrated that GnRH can safely and effectively achieve immune castration in boars after coupling T cell epitopes, palmitic acid modification and W-O-W coating. Provide a better method for the further development of GnRH and the realization of animal welfare.
Driven to Snack: Simulated Driving Increases Subsequent Consumption
Authors: van Meer Floor , Murphy Stephen Lee , Hofmann Wilhelm , van Steenbergen Henk , Van Dillen Lotte F. 
Published: April 2023

When individuals eat while distracted, they may compensate by consuming more afterwards. Here, we examined the effect of eating while driving, and explored potential underlying mechanisms. Participants (N = 116, 73.3% female) were randomly allocated to complete a driving simulation (distraction condition) or to watch someone else drive (control condition) while consuming 10g (50.8 kcal) of potato chips. Afterwards, participants rated the taste intensity and hedonic experience, reported stress levels, and were then given the opportunity to eat more chips. As hypothesized, participants consumed more chips after the driving simulation. Stress levels were higher in the driving compared to control condition, but were inversely related to consumption amount, ruling out stress as explanatory mechanism. Saltiness ratings differed between the driving and passive viewing condition, only when controlling for stress. The current findings converge with earlier work showing that distracted eating can drive overconsumption, which in turn can lead to long-term health implications. Limitations, implications and potential directions are discussed.
Pinocembrin inhibits migration and invasion of nonsmall cell lung cancer cells by inhibiting STAT3 signaling
Authors: Zhang Jing , Xue Zhiqiang , Wang Bin , Wen Jiaxin , Wang Yunxi 
Published: April 2023

Background: In cancer treatment, targeting the activation of signal transducer and activator of transcription 3 (STAT3) is crucial as it promotes tumor progression and metastasis through the process of epithelial-mesenchymal transition (EMT). Pinocembrin, a dihydroxyflavanone found naturally in propolis and honey, is known for its antioxidant and vasodilating properties. The objective of this study is to explore the potential of pinocembrin in regulating the STAT3 signaling pathway to inhibit migration and invasion of nonsmall cell lung cancer (NSCLC) cells.
Methods: Hematoxylin staining was used to determine the migration and invasion of A549 cells. The relative expression of EMT-related proteins and invasive proteins in A549 cells was determined by Western blot analysis. STAT3 activity was evaluated using a luciferase assay. Overexpression of STAT3 was utilized to assess the role of pinocembrin in regulating STAT3.
Results: Pinocembrin treatment (50 μM) significantly reduced the number of migrating and invasive cells. Pinocembrin upregulated the protein level of E-cadherin and downregulated the protein levels of N-cadherin and vimentin. Additionally, pinocembrin blocked the phosphorylation and activation of STAT3. Overexpression of STAT3 reversed the inhibitory effects of pinocembrin on cell migration and invasion.
Conclusion: Our study demonstrates that pinocembrin can inhibit the activation of STAT3, which is associated with EMT and thereby attenuate migration and invasion in NSCLC cells.
Pengaruh Faktor Daya Tarik Wisata Terhadap Keputusan Berkunjung Wisatawan (Studi Kasus Kota Banda Aceh)
Authors: Pusparani Pusparani 
Published: April 2023

Abstrak Penelitian ini bertujuan untuk mengetahui atraksi, aksesbilitas, amenitas dan ancillary, keputusan berkunjung terhadap keputusan berkunjung di Banda Aceh. Jenis penelitian ini menggunakan deskriptip kuantitatif dengan metode analisis regresi berganda. Teknik pengambilan sampel dengan menggunakan accidental sampling. Populasi dalam penelitian ini adalah seluruh pengunjung yang datang ke Kota Banda Aceh untuk menikmati wisata halal. Sedangkan populasi dalam penelitian ini berjumlah 100 responden. Data diolah dengan program SPSS dengan menggunakan skala likert dari 1 sampai dengan 5. Hasil penelitian menunjukkan bahwa hanya dua faktor daya tarik wisata halal yang mempunyai pengaruh bermakna secara individu yaitu faktor atraksi dan ancillary terhadap keputusan wisatawan dalam mengunjungi obyek wisata. Hal ini menunjukkan bahwa daya tarik wisata halal dikota Banda Aceh memiliki daya tarik tersendiri bagi wisatawan dengan atraksi wisata yang sangat beragam seperti wisata alam,budaya dan buatan yang ada di kota Banda Aceh. Keywords : Atraksi, Aksesbilitas, Amenitas dan Ancillary, Keputusan Berkunjung AbstractThis study aims to determine the attractions, accessibility, amenities and ancillary, the decision to visit on the decision to visit in Banda Aceh. This type of research uses quantitative descriptive with multiple regression analysis method. The sampling technique used was accidental sampling. The population in this study were all visitors who came to Banda Aceh City to enjoy halal tourism. While the population in this study amounted to 100 respondents. The data was processed by the SPSS program using a Likert scale from 1 to 5. The results showed that only two factors of halal tourism attraction had a significant influence individually, namely attraction and ancillary factors on tourists' decisions to visit tourist attractions. This shows that the attraction of halal tourism in the city of Banda Aceh has its own charm for tourists with very diverse tourist attractions such as natural, cultural and artificial tourism in the city of Banda Aceh. Keywords : Tourist Attraction, Hala Tourism, Visiting Decisions
Analsis Pengaruh Motivasi Kerja, Pelatihan dan Kepuasan Kerja Terhadap Prestasi Kerja Pegawai Pada BPKAD Kabupaten Pegunungan Arfak
Authors: Suharsono Desi 
Published: April 2023

AbstrakPenelitian ini bertujuan untuk menganalisis: Pengaruh motivasi kerja, pelatihan dan kepuasan kerja secara parsial terhadap prestasi kerja karyawan; Pengaruh motivasi kerja, pelatihan dan kepuasan kerja secara simultan terhadap kinerja pegawai; Variabel yang paling dominan berpengaruh terhadap prestasi kerja pegawai pada Badan Pengelola Keuangan dan Aset Daerah Kabupaten Pegunngan Arfak. Penelitian ini menggunakan pendekatan kuantitatif yang didukung dengan pendekatan deskriptif untuk menggambarkan objek penelitian dan deskripsi variabel penelitian. Populasi penelitian ini berjumlah 50 orang, penentuan sampel menggunakan sampel jenuh sehingga jumlah sampel penelitian ini sama dengan populasi yaitu 50 orang. Pengumpulan data menggunakan kuesioner dan dokumen, menggunakan Teknik analisis regresi linier berganda.Hasil penelitian menyimpulkan bahwa: Secara parsial motivasi kerja, pelatihan dan kepuasan kerja berpengaruh positif dan signifikan terhadap prestasi kerja karyawan; Secara simultan motivasi kerja, pelatihan dan kepuasan kerja berpengaruh positif dan signifikan terhadap kinerja pegawai; Variabel motivasi kerja berpengaruh paling dominan terhadap kinerja pegawai pada Badan Pengelola Keuangan dan Aset Daerah Kabupaten Pegunungan Arfak Propvinsi Papua Barat. Kata Kunci : Motivasi, pelatihan, kepuasan kerja dan prestasi kerja pegawai.
Pengaruh Kompetensi, Disiplin dan Kompensasi Terhadap Kinerja Pegawai Pada Dinas Tenaga Kerja dan Transmigrasi Provinsi Papua Barat
Authors: Lambi Manuel 
Published: April 2023

Penelitian ini bertujuan untuk menganalisis: 1) pengaruh kompetensi, disiplin kerja dan kompensasi secara parsial terhadap kinerja pegawai Pada Dinas Tenaga Kerja dan Transmigrasi Provinsi Papua Barat,2) pengaruh Kompetensi, disiplin kerja dan kompensasi secara simultan terhadap kinerja pegawai pada Pada Dinas Tenaga Kerja dan Transmigrasi Provinsi Papua Barat., 3) variabel yang paling dominan berpengaruh terhadap kinerja pegawai pada Pada Dinas Tenaga Kerja dan Transmigrasi Provinsi Papua Barat.Hasil penelitian menunjukkan bahwa: 1) Secara parsial Kompetensi berpengaruh terhadap kinerja; 2) Secara parsial Disiplin berpengaruh terhadap kinerja, 3) Secara parsial Kompensasi berpengaruh terhadap kinerja, 4) Secara simultan Kompetensi, Disiplin dan Kompensasi berpengaruh positif terhadap kinerja, 5) Variabel yang paling dominan yang mempengaruhi kinerja adalah variabel Kompetensi, 6) Hasil koefisien determinasi menunjukkan bahwa 85.6% variabel kinerja pegawai dapat dijelaskan oleh variabel independen yaitu Kompetensi (X1), Disiplin (X2), Kompensasi (X3) sedangkan sisanya 14,4% dijelaskan oleh variabel lain di luar model.Kata-kata Kunci : Pengaruh Kompetensii, Disiplin, Kompensasi dan Kinerja.
Pengaruh Gaya Kepemimpinan Instruksi, Konsultasi, Partisipasi Dan Delegasi Terhadap Motivasi Kerja Karyawan Pada Perum Perumnas Regional VII Makassar
Authors: Risal Akhmad , Rina Rina , Adi Yusram 
Published: April 2023

Abstrak Penelitian ini bertujuan untuk menganalisis Pengaruh Gaya Kepemimpinan Intruksi, Konsultasi, Partisipasi dan Delegasi terhadap Motivasi Kerja Karyawan pada Perum Perumnas Regional VII Makassar.Penelitian ini dilakukan di Makassar dengan menggunakan metode survei terhadap 90 orang karyawan pada Perum Perumnas Regional VII Makassar. Pengambilan sampel menggunakan teknikl simple random sampling. Data dikumpulkan melalui wawancara/kuesioner dan dianalisis dengan menggunakan analisis statistik deskriptif dan regresi linier.Hasil penelitian menunjukkan bahwa gaya kepemimpinan intruksi, konsultasi, partisipasi dan delegasi secara simultan maupun parsial berpengaruh positif dan signifikan terhadap motivasi kerja karyawan pada Perum Perumnas Regional VII Makassar, sedangkan gaya kepemimpinan parsitipatif merupakan gaya kepemimpinan yang paling berpengaruh. Kata Kunci: Gaya Kepemimpinan Intruksi, Konsultasi, Partisipasi, Delegasi, Motivasi Kerja AbstractThis study aims to analyze the influence of the Leadership Style of Instruction, Consultation, Participation and Delegation on Employee Motivation at Perum Perumnas Regional VII Makassar.This research was conducted in Makassar using a survey method of 90 employees at Perum Perumnas Regional VII Makassar. Sampling using simple random sampling technique. Data was collected through interviews/questionnaires and analyzed using descriptive statistical analysis and linear regression.The results showed that the leadership style of instruction, consultation, participation and delegation simultaneously or partially had a positive and significant effect on employee motivation at Perum National Housing Regional VII Makassar, while the participative leadership style was the most influential leadership style. Keywords: Instructional Leadership Style, Consultation, Participation, Delegation, Work Motivation