bluuebunny/crossref_metadata_2025_split huggingface dataset:
Liuwei Dihuang Decoction Drug-containing Serum Attenuates
Transforming Growth Factor-β1-induced Epithelial-mesenchymal
Transition in HK-2 Cells by Inhibiting NF-κB/Snail Signaling Pathway
Authors: Pan Jiajun , Jiang Yichen , Huang Yuanyuan , Zhang Haiying , Wang Xi , Luo Chao , Wang Hui , Tang Miao , Pei Gang , Tang Qun 
Published: February 2023

Objectives::
The nuclear factor-κB (NF-κB) signaling pathway plays an important role
in regulating tubular epithelial-mesenchymal transition (EMT), an indispensable cellular programme
for driving organ fibrosis and tumor progression. Liuwei Dihuang Decoction (LWD) is an
effective Chinese formula for treating chronic renal failure.

Methods::
First, by using morphological examination, immunofluorescence staining assay, RTqPCR,
and Western blot analysis, in vitro experiments were designed to analyze NF-κB and EMT
markers (including Snail, α-SMA, and E-cadherin) in transforming growth factor-β1 (TGF-β1)
induced renal tubular epithelial cells (HK-2) and to detect the expression levels of LWD-CS cotreatment.
Then, the recombinant lentiviral vector was overexpressed and knocked down by NF-
κB and transfected into HK-2 cells. Cells were treated with TGF-β1 (10 ng/ml) with blank serum
or LWD-containing serum, respectively, and the expression of these molecules in the NF-κB/Snail
signaling pathway was further evaluated.

Results::
Our results confirmed that TGF-β1 could induce EMT, nuclear translocation of NF-κB
p65, and activate the NF-κB/Snail signaling pathway in HK-2 cells.
Furthermore, NF-κB knocked-down dramatically increases the TGF-β1-induced mRNA and protein
expression level of E-cadherin and reduces the level of Snail and α-SMA; this is reversed by
NF-κB overexpression. LWD can decrease the EMT levels through the NF-κB/Snail signaling
activation in TGF-β1-induced EMT of HK-2 cells.

Conclusion::
The present study provides evidence suggesting a novel mechanism that LWD exerts
anti-fibrosis effects through inhibiting activation of the NF-κB/Snail signaling pathway and consequently
downregulating the TGF-β1-induced EMT in renal tubular epithelial cells.
Kashk and Doogh: The Yogurt-based National Persian Products
Authors: Shahrajabian Mohamad Hesam , Sun Wenli 
Published: February 2023

Abstract:
In this mini-review article, two important dairies which can be considered as functional
foods from west and center of Asia, particularly Iran, have been discussed. Doogh and kashkh
are considered as national drinks in Iran, and have tremendous health benefits. The goal of this
manuscript is to survey the principal roles of Doosh and Kash as natural products in the modern
era. All relevant information was searched for terms of Doogh, Kashk, black kashk, and traditional
drinks from reliable databases, such as PubMed, Science Direct, and Google Scholar.
Doogh is the national Iranian traditional fermented drink produced from diluted yoghurt in dairy
manufacturing units. Doogh, an acidic drink, is flavored with dried mint and rose or other spices.
It may provide high quality protein, vitamins, calcium, and minerals such potassium and magnesium.
It is a good source of probiotics, the healthy bacteria that may aid the gut, and improve the
immune system. The most important microbes in Doogh are Streptococcus thermophilus and
Lactobacillus delbriuekii sp. bulgaricus. Kashk is a typical dairy product served in the Middle
East, mainly in Iran, made from sour milk. It is available as a liquid or in a dried form, which is
important to be soaked and softened before it can be utilized in cooking. Numerous alcohols, aldehyds,
alkenes, alkanes, esters, sulfur compounds, FFAs, ketones, and terpenes were detected in
dried kashk, and the most common volatile compounds reported in kashk samples were two sulfur
compounds (carbon disulfide, disulfide dimethyl), two alkanes (tetradecane, hexadecane),
one terpene (dl-limonene), one aldehyde (nonanal), and methyl naphthalene. Both Doogh and
kashk are dominant sources of protein and minerals in comparison with milk with ability to hold
them longer, which can be considered as functional foods.
Detection of Food Contaminants using Nanotechnology - A Mini Review
Authors: Rajendraprasad Sakthi Devi , Girigoswami Agnishwar , Chakraborty Swati , Girigoswami Koyeli 
Published: February 2023

Abstract:
Ingestion of microbial-contaminated food causes severe health issues due to the outburst
of serious foodborne diseases. To prevent these situations, sensitive and precise detection
of toxins and identification of pathogenic microbes are very important in today’s world. Different
types of toxins include natural, chemical, and metal toxins. Based on their origin, natural toxins
are classified into biotoxins which are produced by microorganisms (algal, bacteria, fungal),
animal toxins, and phytotoxins. Researchers enabled the use of nanomaterials in biosensors, enhancing
sensitivity, stability, and specificity. Nanomaterials like gold, silver, carbon nanotubes,
graphene, magnetic nanoparticles, and quantum dots were commonly used to develop biosensors.
Thus, this mini-review summarizes the old conventional and new analytical methods for detecting
a few natural toxins present in different food samples.
A Review: Drug Excipient Iincompatiblity by Ftir Spectroscopy
Authors: Singh Chander , Rao Komal , Yadav Nikita , Bansal Nidhi , Vashist Yogesh , Kumari Shalini , Chugh Palak 
Published: February 2023

Abstract:For the development of various formulations, it is necessary to check out the drug excipient incompatibility. Whether the drug is compatible with the excipient or not. Because the drug excipient interaction study provides stability data of the drug and shelf life of the drug. Fourier transform infrared spectroscopy is the best method to evaluate the drug excipient incompatibility study. The FTIR spectroscopy theory is based on the idea that molecules have a tendency to absorb particular light frequencies that are unique to the corresponding structure of the molecules. The energies depend on the atomic masses, the related vibronic coupling, and the geometry of the molecular surfaces. For instance, the molecule may be able to absorb the energy present in the incident light, which will cause it to rotate more quickly or vibrate more loudly. In this article, a list of various drugs with different excipients was discussed. This review emphasizes on various examples of drug interaction with a number of excipients on the basis of Fourier Transform infrared spectroscopy data which is based on last 10-12 year research paper, and the principle ,working, applications of infrared spectroscopy were also discussed.
Tea tree (Melaleuca alternifolia) Essential Oil Concentration in Microemulsion
with Antibacterial and Antifungal Activity: An Overview
Authors: Upadhyay Prashant , Malik Pooja , Upadhyay Sukirti 
Published: February 2023

Abstract:
The tea tree (Melaleuca alternifolia), a member of the Myrtaceae family, is a valuable medicinal
and aromatic plant. Tea Tree essential oil (TTO) has many medical applications, including antibacterial,
antifungal, antiviral, antiprotozoal, anti-inflammatory, antioxidant, and anticancer properties.
Although the concentration of TTO in a microemulsion is of economic interest, very few studies
on this product have been conducted. In this study, we look at how different tea tree oil concentrations
in microemulsion formulations affect susceptibility to various bacteria and fungi. TTO susceptibility
in a diverse range of microbial species has now been studied using data from a previously published
literature review survey. Most bacteria are resistant to TTO at concentrations as low as 1.0 percent,
but mucosal skin staphylococci and micrococci, Enterococcus faecalis, and Pseudomonas aeruginosa
have minimum inhibitory concentrations much higher than 2 percent. TTO susceptibility in fungi has
only recently been scrutinized. Fungicidal dosages range from 0.12 to 2 percent, with minimum inhibitory
concentrations ranging from 0.03 to 0.5 percent and the only notable exception is Aspergillus
niger, which contains fungicidal concentrations of up to 8%. The review emphasizes the importance of
new antibacterial and antifungal formulations, as well as the role of natural essential oils in the discovery
of new antibacterial and antifungal agents, and discusses, in brief, all constituents derived from
the essential oil (tea tree) that are in preclinical and clinical development. This paper summarizes human
and food-borne bacteria and fungi susceptibility to tea tree essential oils and their constituents.
Among the many tested, essential oils of spices and herbs (Melaleuca alternifolia) were found to have
the strongest antimicrobial properties. This review looks at a wide range of scientific literature, including
Sci-hub, Google Scholar, Pub, Chem, NCBI, and web books.
One Case of Pituitary Stalk Interruption Syndrome Associated with Liver
Cirrhosis
Authors: Li Dong Mei , He Huan 
Published: February 2023

Introduction:
Pituitary stalk interruption syndrome (PSIS) is featured by hypopituitarism and
a classic triad of absence or slender pituitary stalk, absence or ectopic posterior lobe, and hypoplasia of
the anterior lobe. Hypopituitarism, which induces hormone deficiencies, is associated with non-alcoholic
fatty liver disease (NAFLD) and liver cirrhosis.

Case Presentation:
A 29-year-old male patient was presented with intermittent nosebleeds and underdeveloped
secondary sexual characteristics. Laboratory examination revealed low gonadal hormone,
thyroxine, and cortisol levels. Magnetic resonance imaging revealed an interrupted pituitary stalk, ectopic
posterior pituitary, and hypoplastic anterior pituitary. PSIS was confirmed. Liver cirrhosis was
supported by bilirubin metabolism disorder, abnormal coagulation, the varicose vein of the esophagus
and fundus of the stomach, hypersplenism, and signs on a computer tomography scan. He received
glucocorticoid, levothyroxine, androgen, and human chorionic gonadotropin supplements, and growth
hormone was not given because of poverty. Five months later, the patient developed Cushing-like
symptoms and further deterioration of liver function.

Conclusion:
PSIS can cause liver impairment and even cirrhosis, which may be associated with multiple
hormone deficiencies. A case of PSIS with cirrhosis as the initial symptom and progression of cirrhosis
in the absence of growth hormone (GH) therapy suggests that GH therapy may be important in
PSIS-related cirrhosis.
A Comprehensive Review on Elaeocarpus floribundus Blume
Authors: Sarjerao Borase Bharati , Surana Santosh Subhashchandra 
Published: February 2023

Abstract:Elaeocarpaceae comprises of 615 species in 12 genera which belongs to angiosperm. It is a tropical and subtropical family with few genera extending into the temperate zone. The genus Elaeocarpus consists of about 350 species distributed through Eastern Asia and the Pacific region. Around 2 genera and 33 species of the family are distributed in India. Elaeocarpus floribundus (family: Elaeocarpaceae), commonly known as Indian olive, is famous for its fruits and their medicinal uses. Traditionally local people use leaves for rheumatism, fruits for dysentery and diarrhea and infusion of the bark and leaves are used as mouthwash for inflamed gum. The researchers are attracted to the plant due to its various pharmacological properties like antioxidative capacity, antimicrobial, antihistaminic, antidiarrheal, etc., of different extracts of this plant. The review also aimed to study the morphological characterization and presence of phytochemicals like phenolics, flavonoids, alkaloids, proteins, and carbohydrates. A domain in which the plant has ability to treat cancer, diabetes and infectious diseases. The ethnobotanical and pharmacological data would enable a comprehensive study of the Indian olive.
Furnace vestibule heat transport models
Authors: McGuinness Mark , Cox Barry , Kalyanaraman Balaje , Kiradjiev Kristian , Gonzalez-Farina Raquel , Hassell Sweatman Catherine , Roberts Lindon , Pontin David , Bissaker Edward , Irvine Samuel , Jenkins David , Taggart Ian 
Published: February 2023

This is a report on the Lovells Springs challenge that was brought to the Mathematics in Industry Study Group at the University of Newcastle, Australia, in January 2020. The design of a furnace that heats steel rods to make them malleable and allow the reshaping of the rods into coiled springs is the challenge. Mathematical modelling of heat transport in the half-metre long furnace vestibule predicts the effect of vestibule geometry on the temperature of rods entering the furnace, and provides guidelines for deciding on the dimensions of the vestibule for improved energy efficiency of heating. Models considered include treating the rods as equivalent steel sheets, and as discrete steel rods. The relative importance of radiative and convective heat transfer mechanisms is considered. A longer vestibule, with length one or two metres, is recommended for improved heating efficiency of rods thicker than 25mm.
Opt-In and Opt-Out Consent Procedures for the Reuse of Routinely Recorded Health Data in Scientific Research and Their Consequences for Consent Rate and Consent Bias: Systematic Review
Authors: de Man Yvonne , Wieland-Jorna Yvonne , Torensma Bart , de Wit Koos , Francke Anneke L , Oosterveld-Vlug Mariska G , Verheij Robert A 
Published: February 2023

Background
Scientific researchers who wish to reuse health data pertaining to individuals can obtain consent through an opt-in procedure or opt-out procedure. The choice of procedure may have consequences for the consent rate and representativeness of the study sample and the quality of the research, but these consequences are not well known.

Objective
This review aimed to provide insight into the consequences for the consent rate and consent bias of the study sample of opt-in procedures versus opt-out procedures for the reuse of routinely recorded health data for scientific research purposes.

Methods
A systematic review was performed based on searches in PubMed, Embase, CINAHL, PsycINFO, Web of Science Core Collection, and the Cochrane Library. Two reviewers independently included studies based on predefined eligibility criteria and assessed whether the statistical methods used in the reviewed literature were appropriate for describing the differences between consenters and nonconsenters. Statistical pooling was conducted, and a description of the results was provided.

Results
A total of 15 studies were included in this meta-analysis. Of the 15 studies, 13 (87%) implemented an opt-in procedure, 1 (7%) implemented an opt-out procedure, and 1 (7%) implemented both the procedures. The average weighted consent rate was 84% (60,800/72,418 among the studies that used an opt-in procedure and 96.8% (2384/2463) in the single study that used an opt-out procedure. In the single study that described both procedures, the consent rate was 21% in the opt-in group and 95.6% in the opt-out group. Opt-in procedures resulted in more consent bias compared with opt-out procedures. In studies with an opt-in procedure, consenting individuals were more likely to be males, had a higher level of education, higher income, and higher socioeconomic status.

Conclusions
Consent rates are generally lower when using an opt-in procedure compared with using an opt-out procedure. Furthermore, in studies with an opt-in procedure, participants are less representative of the study population. However, both the study populations and the way in which opt-in or opt-out procedures were organized varied widely between the studies, which makes it difficult to draw general conclusions regarding the desired balance between patient control over data and learning from health data. The reuse of routinely recorded health data for scientific research purposes may be hampered by administrative burdens and the risk of bias.
Online Health Information Seeking for Mpox in Endemic and Nonendemic Countries: Google Trends Study
Authors: Shepherd Thomas , Robinson Michelle , Mallen Christian 
Published: February 2023

Background
The recent global outbreak of mpox (monkeypox) has already been declared a public health emergency of international concern by the World Health Organization. Given the health, social, and economic impacts of the COVID-19 pandemic, there is understandable concern and anxiety around the emergence of another infectious disease—especially one about which little is known.

Objective
We used Google Trends to explore online health information seeking patterns for mpox in endemic and nonendemic countries and investigated the impact of the publication of the first in-country case on internet search volume.

Methods
Google Trends is a publicly accessible and free data source that aggregates worldwide Google search data. Google search data were used as a surrogate measure of online health information seeking for 178 days between February 18 and August 18, 2022. Searching data were downloaded across this time period for nonendemic countries with the highest case count (United States, Spain, Germany, United Kingdom, and France) and 5 endemic countries (Democratic Republic of Congo, Nigeria, Ghana, Central African Republic, and Cameroon). Joinpoint regression analysis was used to measure changes in searching trends for mpox preceding and following the announcement of the first human case.

Results
Online health information seeking significantly increased after the publication of the first case in all the nonendemic countries—United States, Spain, Germany, United Kingdom, and France, as illustrated by significant joinpoint regression models. Joinpoint analysis revealed that models with 3 significant joinpoints were the most appropriate fit for these data, where the first joinpoint represents the initial rise in mpox searching trend, the second joinpoint reflects the start of the decrease in the mpox searching trend, and the third joinpoint represents searching trends’ return to searching levels prior to the first case announcement. Although this model was also found in 2 endemic countries (ie, Ghana and Nigeria), it was not found in Central African Republic, Democratic Republic of Congo, or Cameroon.

Conclusions
Findings demonstrate a surge in online heath information seeking relating to mpox after the first in-country case was publicized in all the nonendemic countries and in Ghana and Nigeria among the endemic counties. The observed increases in mpox searching levels are characterized by sharp but short-lived periods of searching before steep declines back to levels observed prior to the publication of the first case. These findings emphasize the importance of the provision of accurate, relevant online public health information during disease outbreaks. However, online health information seeking behaviors only occur for a short time period, and the provision of accurate information needs to be timely in relation to the publication of new case-related information.
Enhancing prospective mathematics teachers' lesson planning skills through lesson study within school university partnership program
Authors: Fitriati Fitriati , Rosli Roslinda , H Iksan Zanaton 
Published: February 2023

Planning a mathematics lesson plan is a complex process. Its quality contributes to the effectiveness of mathematics instruction. Given this significance, improving prospective mathematics teachers’ lesson planning ability is essential for teacher preparation programs to produce effective teachers. This study examines how a lesson study within a school-university partnership program (SUPER-LS) could strengthen the lesson planning skills of prospective mathematics teachers. This study employed a case study, which included thirteen student teachers. Data were collected using four initial and four final drafts of mathematics lesson plans developed by four groups of prospective mathematics teachers and reflection reports. These were then analyzed qualitatively using the framework of MKT. The study found that sixteen categories of issues were present in the initial lesson plan, and six remained in the final lesson plan. In the final lesson plan, the 16 problems were reduced to 6, with an improvement of around 62.50%. In addition, prospective mathematics teachers improved their lesson planning skills because of their involvement in the SUPER-LS program, facilitated by intensive collaboration and interaction among participants, especially in-service teachers, and teacher educators, as well as peers’ feedback.
STRATEGI PENGEMBANGAN KAMPUNG KOTA TEMATIK DI KOTA MALANG Studi Parameter Pendekatan (3B) Berkelanjutan, Berketahanan dan Berkearifan
Authors: Afdholy Amar Rizqi , Hamka Hamka 
Published: February 2023

Peralihan fungsi kampung kota menjadi tempat wisata beberapa waktu ini sedang banyak terjadi di kota-kota besar seperti Kota Malang. Di Kota Malang terdapat puluhan kampung tematik hasil dari lomba kampung tematik yang diinisiasi pada tahun 2016, namun tidak banyak yang mampu bertahan dan berlanjut karena banyak faktor. Penelitian ini bertujuan untuk merumuskan parameter dan rekomendasi strategi pengembangan untuk mewujudkan wisata kampung kota tematik yang berkelanjutan, berketahanan, dan berkearifan (3B). Agar kampung kota tersebut mampu bertahan, beradaptasi, dan tumbuh dari tekanan dan guncangan pada kondisi tidak normal seperti bencana, sehingga kehidupan normal selanjutnya mampu pulih dengan cepat. Metode penelitian menggunakan metode kualitatif dengan pendekatan analisis deskriptif. Proses analisis aspek berkelanjutan berdasarkan studi literatur terdahulu untuk merumuskan parameter dan strategi pengembangan kawasan kampung kota yang ada di Kota Malang. Dari hasil penelitian ditemukan aspek pengembangan berkelanjutan dan berketahanan yang perlu dipertimbangkan, meliputi aspek sosial budaya, ekonomi, teknologi, arsitektur, lingkungan, keterlibatan, politik, kelembagaan, legal, ekuitas, livabilitas, infrastruktur, pendidikan dan kesehatan. Parameter berkelanjutan meliputi kota cerdas, wisata, arsitektur dan lanskap berkelanjutan. Parameter berketahanan meliputi kebertahanan terhadap penyakit/ pandemi, komunitas, institusi, lingkungan kota, perubahan iklim, pangan dan energi. Sedangkan nilai berkearifan yang dapat diterapkan perlu disesuaikan dengan karakteristik lingkungan sosial budaya pada masing-masing kampung kota.