bluuebunny/crossref_metadata_2025_split huggingface dataset:
Meta-analysis of cancer risk among end stage renal disease undergoing maintenance dialysis
Authors: Xie Xin , Li Fang , Xie Longsheng , Yu Yanxia , Ou Santao , He Rongfang 
Published: February 2023

Abstract
Currently, there is no consensus on whether maintenance dialysis increases cancer risk in patients with end-stage renal disease (ESRD). Therefore, this study was to systematically evaluate the risk of cancer among ESRD patients undergoing maintenance dialysis. Related studies on the impact of maintenance dialysis on cancer risk were retrieved from PubMed, Embase, Cochrane Library, and other databases from their respective inceptions to 19 February 2021. ESRD patients receiving maintenance dialysis were classified into cancer including non-melanoma skin cancer (NMSC) and cancer excluding NMSC. Standardized incidence ratio (SIR) with its 95% confidence interval (95% CI) was calculated to assess cancer risk. Fourteen studies were included in the meta-analysis. The risk of cancer in patients undergoing maintenance dialysis (with or without NMSC) was significantly higher than controls both in cancer including NMSC (SIR = 1.38, 95% CI: 1.27–1.49, P < 0.001) and cancer excluding NMSC (SIR = 1.34, 95% CI: 1.23–1.47, P < 0.001). Subgroup results identified the higher risk of cancer incidence in both men and women receiving maintenance dialysis. Meanwhile, elevated excess risks were observed among patients with younger age and shorter follow-up time (P < 0.001). Meanwhile, the combined SIR of bladder, cervix, colorectum, kidney, liver, thyroid, tongue, and other cancers were all increased (P < 0.05). ESRD patients undergoing dialysis has higher risk of cancer.
Mechanical properties and durability of ultra-high-performance concrete with calcined diatomaceous earth as cement replacement
Authors: Hasan Muttaqin , Jamil Muhammad , Saidi Taufiq 
Published: February 2023

Abstract
Calcined diatomaceous earth (CDE) with a maximum grain size of 143 μm was used to partially replace 5 and 10% of cement in ultra-high-performance concrete (UHPC) mixtures. The other materials used in producing the concrete include Ordinary Portland Cement, iron ore powder, and river sand with maximum grain sizes 112.5, 231, and 766.2 μm, respectively. Moreover, the UHPC specimens designed with a water–cement ratio of 0.2 and a superplasticizer of 1.5% from the cement weight were tested for flow, compressive strength, flexural strength, splitting tensile strength, durability against NaCl and Na2SO4 attack, and resistance to 400, 500, and 600°C temperatures. The results showed that the use of 5 and 10% CDE to replace cement was able to increase the compressive strength, flexural strength, splitting tensile strength, the durability of UHPC against NaCl, and Na2SO4, as well as its resistance to high temperatures but reduced the mixture flow.
Telecom single-photon emitters in GaN operating at room temperature: embedment into bullseye antennas
Authors: Meunier Max , Eng John J. H. , Mu Zhao , Chenot Sebastien , Brändli Virginie , de Mierry Philippe , Gao Weibo , Zúñiga-Pérez Jesús 
Published: February 2023

Abstract
The ideal single-photon source displaying high brightness and purity, emission on-demand, mature integration, practical communication wavelength (i.e., in the telecom range), and operating at room temperature does not exist yet. In 2018, a new single-photon source was discovered in gallium nitride (GaN) showing high potential thanks to its telecom wavelength emission, record-high brightness, good purity, and operation at room temperature. Despite all these assets, its coupling to photonic structures has not been achieved so far. In this article, we make a first step in this direction. First, we analyze whether stacking faults are indeed a necessary condition for obtaining such emitters in GaN layers. Then, we discuss the challenges associated to a low spatial density and to a spectrally wide distribution of emitters, which necessitate their location to be determined beforehand and the photonic structure resonance to be tuned to their emission wavelength. The design and fabrication of bullseye antennas are thoroughly described. Finally, we fabricate such bullseyes around telecom emitters and demonstrate that the embedded emitters are able to sustain the necessary clean-room process and still operate as single-photon emitters after the fabrication steps, with room-temperature purities up to 99% combined with repetition rates in the order of hundreds of kHz. The findings in this work demonstrate that telecom single-photon emitters in GaN operating at room temperature are well adapted for single-photon applications where brightness and purity are the required figures of merit, but highlight the numerous difficulties that still need to be overcome before they can be exploited in actual quantum photonic applications.
One-pot synthesis and crystal structure of diethyl 2,6-dimethyl-4-(1-(2-nitrophenyl)-1H-1,2,3-triazol-4-yl)-1,4-dihydropyridine-3,5-dicarboxylate, C21H23N5O6
Authors: Konovalova Irina S. , Geleverya Anna O. , Kovalenko Sergiy M. , Reiss Guido J. 
Published: February 2023

Abstract
C21H23N5O6, monoclinic, P21/c (no. 14), a = 8.4861(4) Å, b = 16.3198(8) Å, c = 15.8521(8) Å, β = 97.605(5)°, V = 2176.1(2) Å3, Z = 4, R
gt(F) = 0.0463, wR
ref = 0.1201, T = 293(2) K.
Apigenin improves cytotoxicity of antiretroviral drugs against HTLV-1 infected cells through the modulation of AhR signaling
Authors: Sales Dominic , Lin Edward , Stoffel Victoria , Dickson Shallyn , Khan Zafar K. , Beld Joris , Jain Pooja 
Published: February 2023

Abstract

Objectives
HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a neuroinflammatory autoimmune disease characterized by high levels of infected immortalized T cells in circulation, which makes it difficult for antiretroviral (ART) drugs to work effectively. In previous studies, we established that Apigenin, a flavonoid, can exert immunomodulatory effects to reduce neuroinflammation. Flavonoids are natural ligands for the aryl hydrocarbon receptor (AhR), which is a ligand activated endogenous receptor involved in the xenobiotic response. Consequently, we tested Apigenin’s synergy in combination with ART against the survival of HTLV-1-infected cells.

Methods
First, we established a direct protein-protein interaction between Apigenin and AhR. We then demonstrated that Apigenin and its derivative VY-3-68 enter activated T cells, drive nuclear shuttling of AhR, and modulate its signaling both at RNA and protein level.

Results
In HTLV-1 producing cells with high AhR expression, Apigenin cooperates with ARTs such as Lopinavir (LPN) and Zidovudine (AZT), to impart cytotoxicity by exhibiting a major shift in IC50 that was reversed upon AhR knockdown. Mechanistically, Apigenin treatment led to an overall downregulation of NF-κB and several other pro-cancer genes involved in survival.

Conclusions
This study suggest the potential combinatorial use of Apigenin with current first-line antiretrovirals for the benefit of patients affected by HTLV-1 associated pathologies.
Properties of potassium dihydrogen phosphate and its effects on plants and soil
Authors: Jančaitienė Kristina , Šlinkšienė Rasa , Žvirdauskienė Renata 
Published: February 2023

Abstract
One of the challenges of the modern world is to improve human nutrition and to safely increase the yield of agricultural production using existing agricultural land. It is clear that sufficient agricultural efficiency cannot be achieved without fertilizers, but fertilizers must cause minimal damage to the soil. Microorganisms, such as spore-forming bacteria, actinomycetes, fungi, algae, and protozoa play an important role in the soil and keep soil healthy. One of the soil substances involved in reactions that take place in plants is cellulose. This study investigated the effect of potassium dihydrogen phosphate (PDP), synthesized (via conversion between potassium chloride and ammonium dihydrophosphate) and granulated with the addition of microcrystalline cellulose (MC), on plants (winter wheat Toras, Lithuania) and soil microorganisms. The data of plants fertilized with pure KH2PO4, ones fertilized with PDP granulated with MC, and grown without fertilizers were compared in this study. Scanning electron microscopy and differential scanning calorimetry analysis were used to characterize the obtained product. One-way analysis of variance was used to evaluate the differences of the mean values between groups. In all cases, the significance level was p ≤ 0.05. The effect of pure KH2PO4 on plant indicators was found to be lower than that of granular PDP with MC. The length of the leaves was 29.63 and 31.20 cm, green mass was 0.471 and 0.763 g, ash mass was 0.015 and 0.019 g, respectively. In addition, granular PDP with MC did not adversely affect the soil microorganisms because the number of any species of bacteria (Spore b., mineral nitrogen assimilating bacteria, cellulose degrading bacteria) did not decrease and a slight increase in the number of Actinomycetes (from 8.5 × 105 to 2.9 × 106 KSV/g) and molds (from 3.0 × 104 to 1.4 × 105 KSV/g) was observed. The granular PDP with MC that we developed and used have better physical properties, higher agrochemical efficiency and cause less harm to soil microorganisms compared to pure PDP.
Alltagssprache, Beschreibungssprache und praxeologische Validität
Authors: Meier zu Verl Christian , Meyer Christian , Oberzaucher Frank 
Published: February 2023

Zusammenfassung
Dieser Beitrag ergänzt die Debatte über sozialwissenschaftliche Güte um zwei Dimensionen. Erstens diskutieren wir anhand einiger Positionen des interpretativen Paradigmas, welche Konsequenzen sich aus der doppelten Relevanz von Sprache als sowohl Bestandteil des Gegenstands, als auch Medium wissenschaftlicher Beschreibung für die Bewertung sozialwissenschaftlicher Güte ergeben. Eine rigide Forschung muss sich in Bezug auf diese doppelte Relevanz positionieren und diese Position konsistent umsetzen. Zweitens schlagen wir das ethnomethodologische Konzept der praxeologischen Validität als bislang übersehenes Gütekriterium vor. Praxeologische Validität ist immer dann gewährleistet, wenn die Prozeduren zur Erzeugung sozialer Phänomene nach ihrer Identifikation und Beschreibung so reproduziert werden können, dass die Phänomene selbst erneut entstehen. Dieses Kriterium gibt Soziolog:innen die Möglichkeit, die Angemessenheit soziologischer Beschreibungen am Gegenstand selbst zu validieren.
Load-Deflection Response of Steel-Basalt Hybrid Fiber–Reinforced Copper Slag Concrete Beams
Authors: Dharmar Brindha , John Vinotha Jenifer 
Published: February 2023

Abstract
In the proposed research, the load-deflection response of hybrid fiber (steel and basalt fibers) reinforced copper slag concrete was investigated based on the studied mechanical properties of hybrid-fiber concrete such as compression, tension, flexure, fracture, and microstructure. Based on various experimental results, the optimum volume fraction of steel and basalt fibers was identified and fused together in hybrid form to study its behavior under static loading conditions. The objective of the study was to observe the influence of hybrid fibers as the primary reinforcement in concrete beams. The results were promising, indicating higher energy absorption ability. The developed combination of hybrid-fiber concrete was investigated for various parameters such as first-cracking behavior, load-deflection pattern, energy absorption capacity, ductility characteristics, stiffness of beams, and failure mode of beams subjected to load-deflection behavior. Significant results were obtained by replacing steel rebars as the primary reinforcement with regard to post-peak response and ductility.
Vestibular Contributions to Primate Neck Postural Muscle Activity during Natural Motion
Authors: Mildren Robyn L. , Cullen Kathleen E. 
Published: February 2023

To maintain stable posture of the head and body during our everyday activities, the brain integrates information across multiple sensory systems. Here, we examined how the primate vestibular system, independently and in combination with visual sensory input, contributes to the sensorimotor control of head posture across the range of dynamic motion experienced during daily life. We recorded activity of single motor units in the splenius capitis and sternocleidomastoid muscles in rhesus monkeys during yaw rotations spanning the physiological range of self-motion (up to 20 Hz) in darkness. Splenius capitis motor unit responses continued to increase with frequency up to 16 Hz in normal animals, and were strikingly absent following bilateral peripheral vestibular loss. To determine whether visual information modulated these vestibular-driven neck muscle responses, we experimentally controlled the correspondence between visual and vestibular cues of self-motion. Surprisingly, visual information did not influence motor unit responses in normal animals, nor did it substitute for absent vestibular feedback following bilateral peripheral vestibular loss. A comparison of muscle activity evoked by broadband versus sinusoidal head motion further revealed that low-frequency responses were attenuated when low- and high-frequency self-motion were experienced concurrently. Finally, we found that vestibular-evoked responses were enhanced by increased autonomic arousal, quantified via pupil size. Together, our findings directly establish the vestibular system's contribution to the sensorimotor control of head posture across the dynamic motion range experienced during everyday activities, as well as how vestibular, visual, and autonomic inputs are integrated for postural control.SIGNIFICANCE STATEMENTOur sensory systems enable us to maintain control of our posture and balance as we move through the world. Notably, the vestibular system senses motion of the head and sends motor commands, via vestibulospinal pathways, to axial and limb muscles to stabilize posture. By recording the activity of single motor units, here we show, for the first time, that the vestibular system contributes to the sensorimotor control of head posture across the dynamic motion range experienced during everyday activities. Our results further establish how vestibular, autonomic, and visual inputs are integrated for postural control. This information is essential for understanding both the mechanisms underlying the control of posture and balance, and the impact of the loss of sensory function.
Role of glucose variability on linear growth in children with type 1 diabetes
Authors: Blasetti Annalisa , Castorani Valeria , Polidori Nella , Mascioli Ilaria , Chiarelli Francesco , Giannini Cosimo 
Published: February 2023

Objective
Linear growth is impaired in children with type 1 diabetes (T1D) and poor metabolic control. A good metabolic control is a key therapeutic goal to prevent vascular complications and also to ensure appropriate anthropometric development during childhood. In this study, we aimed to identify and characterize the effects of glycemic variability on linear growth in children with T1D.

Methods
Data from 144 prepubertal children with T1D were evaluated. Anthropometric measurements (weight, weight-SDS, height, height-SDS, BMI, BMI-SDS) were collected and glycosylated hemoglobin (HbA1c) was measured at admission and every 4 months over a 2-year period. Glycemic variability indexes (glycemic coefficient of variation (CV), glycemic CV percentage (CV%), and the product between HbA1c-mean and HbA1c-SDS/100 (M*SDS-HbA1c/100)) were calculated. According to height-SDS changes after 2 years of follow-up, the study population was divided into three tertile groups and differences across groups were investigated for variables of interest.

Results
The three groups were similar in terms of age, gender, and follow-up period. After 2 years, all prepubertal children showed a significant positive trend of anthropometric data. Across the three tertile groups, HbA1c-SDS, CV, CV%, and M*SDS-HbA1c significantly decreased from the first to the third tertile of height-SDS. During follow-up, children with lower Δheight-SDS values reported higher values of HbA1c-SDS, CV, CV%, and M*SDS-HbA1c than subjects with higher linear growth.

Conclusions
Glycemic variability correlates with linear growth in children with T1D. Low glycemic variability indexes were reported in higher height-SDS tertiles. Δheight-SDS is inversely correlated with glycemic CV, CV%, and M*SDS-HbA1c.
TraceNet: An Effective Deep-Learning-Based Method for Baseline Correction of Near-Field Acceleration Records
Authors: Dong Sheng , Li Zhengbo , Hu Feng , Yu Zhenjiang , Chen Xiaofei 
Published: February 2023

AbstractIn strong ground-motion observations, accelerograms are an important material in both seismic research and earthquake engineering. However, the ubiquitous baseline drift in near-field acceleration records has a large impact on the integrated velocity and double-integrated displacement with linear and parabolic drift, respectively. Conventionally, high-pass filtering and two-stage baseline fitting methods are commonly applied in baseline corrections to obtain reliable strong-motion records. However, these filtering methods exclude low-frequency components from acceleration records and cause unexpected waveform loss. The baseline fitting method, which is based on the experiential selection of intersection moments, is easily affected by external factors and requires a large amount of time for operations. Currently, as the number of accelerometers grows, conventional methods are insufficient in both efficiency and precision to process vast acceleration records. Here, we propose TraceNet, a deep-learning-based method, to correct baseline drifts in velocity records integrated from accelerograms. The training data set is developed with the fusion of artificial baselines and nondrift velocities from corrected accelerations and displacements from events. TraceNet extracts the baseline from the input velocity trace. After TraceNet prediction, the drift can be corrected by subtracting the extracted baseline. In addition, the potential coseismic ground displacement can be recovered from the integration in the corrected velocity. In this study, we used acceleration records and continuous Global Positioning System observations from the 2008 Wenchuan earthquake to demonstrate the ground offset recovery. As a deep learning application, TraceNet can extract and correct the baseline drifts automatically without subjective factors. The coseismic displacements estimated from accelerograms can provide additional insight into the ground deformation.
Atenção à saúde bucal na atenção primária à saúde em Portugal: Perceção dos médicos dentistas portugueses
Authors: Nunes Manuel Lourenço , Nunes Alexandre Morais 
Published: February 2023

Objetivos: o presente estudo objetivou analisar as perceções dos médicos dentistas relativamente à implementação da atenção à saúde bucal na atenção primária à saúde em Portugal. Métodos: estudo exploratório-descritivo, de abordagem qualitativa, realizado com recurso a entrevista semiestruturada gravada aplicada a 75 médicos dentistas. A coleta de dados ocorreu entre julho e dezembro de 2017, sendo utilizada para a análise a técnica da análise de conteúdo. Resultados: as falas revelam a importancia da realização de tratamentos e educação em saúde bucal integrada na equipe de saúde da atenção primária à saúde. Conclusões: Em conformidade com a literatura, os dentistas destacam a importância do reforço da atenção à saúde bucal de acesso universal integrada no Serviço Nacional de Saúde, reforçam a necessidade de criar mais equipes de saúde bucal (médico dentista, higienista e assistentes) em toda a atenção primária e destacam a necessidade da implementação de uma carreira médica de medicina dentária para promover a colocação de mais médicos dentistas em zonas mais carenciadas.
La legislación cooperativa en Uruguay
Authors: Reyes Lavega Sergio 
Published: February 2023

Durante el siglo XX la legislación sobre cooperativas en Uruguay se basó en el criterio de regular por cada rama del cooperativismo, lo que llevó a un cuadro fragmentario y poco homogéneo. En 2008, en cambio, se aprobó la Ley General de Cooperativas N.° 18.407, la cual dio unidad y armonía al régimen jurídico de las cooperativas, a la vez que incorporó nuevos instrumentos a fin de que estas entidades pudieran adecuar su desarrollo y actividades a los tiempos modernos. En este artículo, luego de una muy breve referencia a los antecedentes legislativos, se hace una descripción completa de la legislación cooperativa vigente para todas las clases de cooperativas en Uruguay.
Recibido: 03 noviembre 2022Aceptado: 08 diciembre 2022
Las cooperativas y la negociación colectiva en Uruguay
Authors: Guerra Pablo 
Published: February 2023

En este artículo describiremos las principales características del sistema de relaciones laborales y de cómo el sector cooperativo se inserta en él, particularmente en materia de Consejos de Salarios, esto es, el principal mecanismo de negociación colectiva establecido en el país a partir del año 1943 y que obliga al binomio capital-trabajo a participar de la negociación salarial junto al Estado. Una de las premisas que estaremos manejando desde el punto de vista conceptual, es que esta negociación de carácter tripartito tiene su explicación y origen en el marco de los normales conflictos gestados entre empleadores (empresas de capital) y trabajadores (organizados vía sindical). Tal diseño no fue pensado para el sector de la economía social y solidaria de tal manera que difícilmente pueda desarrollarse su identidad específica si debe elegir participar junto a las Cámaras Empresariales o a los Sindicatos. Esto nos lleva a analizar las posibilidades de una vía cuatripartita en la que la identidad del sector se exprese por medio de una estrategia de participación más acorde a un formato empresarial alternativo.
Recibido: 03 noviembre 2022Aceptado: 12 enero 2023
Las cooperativas agrarias y las sociedades de fomento rural. Evolución y situación actual
Authors: Arboleya Luis Ignacio 
Published: February 2023

Las formas cooperativas y asociativas vinculadas al medio rural uruguayo son de larga data. Con más de cien años de trayectoria, las diversas formas asociativas con espíritu cooperativo han buscado resolver diferentes necesidades de los productores rurales, especialmente los familiares. Los antecedentes más significativos e históricos del cooperativismo agropecuario uruguayo indican el ensayo de diversas estrategias para aprovechar oportunidades, ganar escala y poder negociador mediante la cooperación entre entidades agrarias o el desarrollo de nuevos servicios. El presente artículo busca describir la trayectoria y estrategias que han adoptado las organizaciones asociativas/ cooperativas rurales uruguayas frente a los cambios del entorno (especialmente los mercados y los enfoques de política sectoriales) y los desafíos que enfrentan hacia el futuro.
Recibido: 03 noviembre 2022Aceptado: 09 enero 2023