bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sources and pathways of halomethoxybenzenes in northern Baltic estuaries
Authors: Bidleman Terry , Agosta Kathleen , Andersson Agneta , Brugel Sonia , Ericson Lars , Hansson Katarina , Nygren Olle , Tysklind Mats 
Published: May 2023

IntroductionThousands of halogenated natural products (HNPs) are generated in the ocean and on land. A subset of these, halomethoxybenzenes (HMBs), are released from both natural and anthropogenic sources. Here we consider: 1. Brominated anisoles (BAs), transformation products of bromophenols. 2. Drosophilin A methyl ether (DAME: 1,2,4,5-tetrachloro-3,6-dimethoxybenzene), a secondary metabolite of terrestrial fungi. 3. Tetrachloroveratrole (TeCV: 1,2,3,4-tetrachloro-5,6-dimethoxybenzene), a lignin byproduct found in bleached kraft mill effluent. 4. Pentachloroanisole (PeCA), a metabolite of the wood preservative pentachlorophenol.MethodsWe examined several ecosystem compartments to determine sources and exchange processes for these HMBs: air, precipitation, rivers, forest fungi and litter, and water from northern Baltic estuaries and offshore. Samples were analyzed for HMBs by capillary gas chromatography – quadrupole mass spectrometry.Results and discussionAll four types of HMBs were found in air, and BAs, DAME and TeCV were also present in precipitation. BAs and DAME were common in rivers and estuaries, whereas TeCV was low and PeCA was below detection. DAME was identified in several species of fungi and in forest litter; TeCV was occasionally present, but BAs and PeCA were below detection. Concentrations of BAs were higher in estuaries than in rivers or offshore waters, showing that estuaries are hot spots for production. BAs were negatively or not correlated with chlorophyll-a, suggesting contribution by heterotrophic bacteria as well as known production by phytoplankton and macroalgae. DAME was negatively or not correlated with BAs and did not appear to be produced in the estuaries; fungi and forest litter containing fungal mycelia are suggested as sources. HMBs volatilize from sea and land, disperse through the atmosphere, and return via precipitation and rivers. Production and biogeochemical cycles are influenced by climate change and we suggest BAs and DAME for following partitioning and exchange processes.
Endoscopic total parathyroidectomy via anterior chest approach with forearm autotransplantation for secondary hyperparathyroidism: a comparison of surgical results with open total parathyroidectomy with autotransplantation
Authors: Hua Tebo , Lou Jinfeng , Zhu Ye , Luo Yong , Zhang Hai , Yang Jiahui 
Published: May 2023

ObjectiveThis paper aimed to evaluate the clinical value of performing an endoscopic total parathyroidectomy through anterior chest approach with autotransplantation (EACtPTx+AT) in treating secondary hyperparathyroidism (SHPT) to summarize and share the clinical experience.Methods24 patients with SHPT were retrospectively analyzed:11 patients underwent open total parathyroidectomy with autotransplantation (OtPTx+AT Group) and 13 patients underwent endoscopic parathyroidectomy through anterior chest approach with autotransplantation (EACtPTx+AT Group). Comparing the two groups regarding the following factors: (1) operating conditions, such as the blood loss during the operation, the length of time spent on the operating table, the number of parathyroid glands removed, postoperative drainage volume and hospital stay. (2) clinical efficacy, parathyroid hormone (PTH) and serum calcium (Ca) levels. (3) postoperative complications.ResultsFirst, there were no significant differences in the number of parathyroid gland resection, operation time, intraoperative blood loss and hospital stay between the two groups. While there were significant differences in postoperative drainage volume between the two groups. Second, the two groups preoperative PTH and preoperative serum calcium decreased significantly compared with those of the two groups after surgery and there was a statistically significant difference. Thirdly, there was no postoperative bleeding, hoarseness or choking in the two groups and no conversion to open surgery case in EACtPTx+AT group.ConclusionEndoscopic treatment of SHPT using the anterior chest approach with forearm autotransplantation significantly improves clinical symptoms and lowers levels of PTH and serum calcium after the operation. The results confirm the operation’s safety and effectiveness.
Chloramphenicol Derivatization in Its Primary Hydroxyl Group with Basic Amino Acids Leads to New Pharmacophores with High Antimicrobial Activity
Authors: Tsirogianni Artemis , Kournoutou Georgia G. , Mpogiatzoglou Maria , Dinos George , Athanassopoulos Constantinos M. 
Published: May 2023

In a previous study published by our group, successful modification of the antibiotic chloramphenicol (CHL) was reported, which was achieved by replacing the dichloroacetyl tail with alpha and beta amino acids, resulting in promising new antibacterial pharmacophores. In this study, CHL was further modified by linking the basic amino acids lysine, ornithine, and histidine to the primary hydroxyl group of CHL via triazole, carbamate, or amide bonding. Our results showed that while linking the basic amino acids retained antibacterial activity, it was somewhat reduced compared to CHL. However, in vitro testing demonstrated that all derivatives were comparable in activity to CHL and competed for the same ribosomal binding site with radioactive chloramphenicol. The amino acid–CHL tethering modes were evaluated either with carbamate (7, 8) derivatives, which exhibited higher activity, or with amide- (4–6) or triazole-bridged compounds (1–3), which were equally potent. Our findings suggest that these new pharmacophores have potential as antimicrobial agents, though further optimization is needed.
Synthesis and Photocatalytic Properties of Four Coordination Compounds Constructed from Two Benzimidazole-Based Asymmetric Polyazocyclic Ligands
Authors: Ren Chenfei , Li Jian , Zhang Xingxing , Niu Yunyin 
Published: May 2023

In this paper, two benzimidazole derivative ligands were obtained using o-phenylenediamine and n-pyridine formaldehyde (n = 3, 4) by amine–aldol condensation reactions, which were reacted with selected inorganic metal salts by ambient temperature volatilization method to give compounds 1–4: {[(L1)6]·[Cu8I8]} (1), {[L1]·[CuBr]·H2O} (2), {[L2]·[CuBr]}n (3), and {[(L2)4]·[Cu4I4]} (4). They were characterized by IR, UV-Vis absorption spectroscopy, thermogravimetric analysis, and single crystal X-ray analysis. Simultaneously, compounds 1–4 were found to possess photocatalytic degradation of ciprofloxacin (CIP) by preliminary experimental investigations.
Patient Safety Trends in 2022: An Analysis of 256,679 Serious Events and Incidents From the Nation’s Largest Event Reporting Database
Authors: Kepner Shawn , Jones Rebecca 
Published: May 2023

Background Pennsylvania is the only state that requires acute care facilities to report all events of harm or potential for harm. The Pennsylvania Patient Safety Reporting System (PA-PSRS) is the largest repository of patient safety data in the United States and one of the largest in the world, with over 4.5 million acute care event reports dating back to 2004. Herein, we examine patient safety event reports submitted to the PA-PSRS acute care database in 2022 and compare them to prior years. Methods We extracted data from PA-PSRS and obtained data from the Pennsylvania Health Care Cost Containment Council (PHC4). Counts of reports were calculated based on report submission date, and rates were calculated based on event occurrence date and calculated per 1,000 patient days for hospitals or 1,000 surgical encounters for ambulatory surgical facilities (ASFs). Results A total of 256,679 reports were submitted to PA-PSRS in 2022, representing an 11.1% decrease from 2021. Three facilities collectively submitted 18,601 fewer reports in 2022 compared to 2021, which accounted for 57.8% of the overall decrease. Reports of serious and high harm events increased by 7.7% and 11.1%, respectively. Of the 256,679 reports submitted, 95.9% were from hospitals, 3.9% were from ambulatory surgical facilities, and 0.2% were from birthing centers and abortion facilities. The vast majority of the 2022 reports were incidents (96.2%) as opposed to serious events (3.8%). For each of the past five years, the most frequently reported event type was Error Related to Procedure/Treatment/Test, accounting for 32.8% of all submitted acute care event reports in 2022. The second, third, and fourth most frequently reported event types in 2022 were Complication of Procedure/Treatment/Test, Medication Error, and Fall, accounting for 15.6%, 13.2%, and 12.8% of submitted reports, respectively. The reported event rate based on occurrence date for hospitals in the first half of 2022 was 27.5 reports per 1,000 patient days. For ASFs, the reported event rate for the first half of 2022 was 9.4 reports per 1,000 surgical encounters. Conclusions There was a decrease in the number of incident reports submitted to PA-PSRS in 2022 and an increase in serious and high harm event reports. PSA will continue to work with facilities, monitor reporting, and take further action as needed.
Impacto da pandemia da COVID-19 em crianças com transtorno do espectro autista
Authors: Costa Giovanna Vieira , Ferreira Isabela Rodrigues Pires , Dos Santos Ana Paula Linhares , Da Silva Wadilla Fiuza , Mesquita Bruna do Carmo , Pires Carla Andréa Avelar , De Freitas Brenda Raine Batista Duck , Dos Santos Giovana Baptista 
Published: May 2023

Objetivo: Analisar e descrever os impactos provocados pela pandemia de COVID-19 em crianças com Transtorno do Espectro Autista. Metodologia: Trata-se de um estudo quantitativo, transversal, descritivo, realizado com responsáveis por pacientes pertencentes ao espectro autista, realizado por meio de questionário online montado no Google Forms e enviados em grupos que reúnem responsáveis de pessoas autistas em redes sociais, como o “Facebook” e o “WhatsApp”. Resultados e discussão: Observou-se que as crianças e adolescentes com TEA podem ser considerados mais vulneráveis à COVID-19, não devido à suscetibilidade às complicações do vírus, mas às características próprias do quadro clínico que dificultam a adequada compreensão do cenário pandêmico, assim como dificuldades em seguir as medidas sanitárias de controle e proteção (62,9%), o que predispõe esse grupo a maiores riscos de contaminação. Dentre as características mais fortemente impactadas pela pandemia, 64,3% dos entrevistados relataram alterações na saúde mental, agressividade, transtornos de sono, aumento da irritabilidade, aparecimento de condutas estereotipadas, além de impulsões e ataques de grito, além de que 58,6% declararam ter ocorrido diminuição da interação social da criança com TEA. Conclusão: Com a adoção de medidas de controle da pandemia do novo Coronavírus, foram observadas alterações nas práticas habituais para a maioria dos indivíduos com TEA.
Simulation and analysis of suspension based single axis mems capacitive accelerometer
Authors: S Veena , A Sthuti , Suresh HL , S Ashik , P Surya , MJ Nagaraj 
Published: May 2023

This paper reports a comparison of different types of springs used in MEMS based capacitive accelerometers. In this work MEMS based Single-axis accelerometers are designed using different Suspension systems. Analysis of the structure is done for resonant frequency of 2kHz. Analytical modeling of the different suspensions is presented for the specified frequency. Stress, displacement and capacitive analysis of the accelerometer is done. The sensitivity of the accelerometer with parallel beam suspension is 70nm/g, 50nm/g for folded beam suspension and 35nm/g for serpentine beam suspension. Hence parallel beam suspension has 0.7 times improved sensitivity than folded beam and 2 times better than serpentine suspension accelerometer. Whereas the stress obtained for folded beam is better than the other two. Hence Parallel beam suspension is preferred for higher sensitivity and accuracy whereas Folded beam suspension is preferred for greater structural stability By comparing these devices, it is concluded that a compromise on certain parameters is required in order meet the requirements. If there is higher displacement sensitivity then there is lower mechanical stability and vice versa. The simulations are carried out using COMSOL Multiphysics.
Optimization of a multipurpose river basin in anambra state, Nigeria
Authors: G Ekwueme O. , O Aronu Charles 
Published: May 2023

In this study, the multipurpose objective of development in the Anambra River basin was examined. The study's goals are to determine the net benefits of the various objectives under each purpose currently carried out by the Anambra River Basin, to identify the best way to achieve the goals, and to show, through logical and mathematical reasoning, how money could be allocated to the various goals of a dam project in Anambra State effectively. Economic Efficiency (EE), Regional Economic Redistribution (RER), Social Well-Being (SW), Youth Empowerment (YE), and Environmental Quality Improvement are the objectives taken into account in the study (EQI). The optimization problem in the multi-purpose-objective development of the Anambra State river basin was solved utilizing the multi-start optimization method. The study showed that the basin would achieve enormous financial benefits if it used its N15.0 billion strategic development budget over four years for various purposes as illustrated. The results showed that the following allocation of the five purposes should be optimized simultaneously for an N15.0 billion four-year strategic development fund: EE should receive N0.762 billion, RER should receive N0.594 billion, SW should receive N0.649 billion, YE should receive N0.683 billion, and environmental quality improvement should receive N4.768 billion. It was found that Environmental Quality Improvement was allocated the higher amount while Regional Economic Redistribution was allocated the least amount for the development. The study's findings recommended that the management of the basin stop the practice of allocating funds to various uses at their discretion, which has led to significant oversight and the improper distribution of scarce resources. As a result, every fund distribution must be justified using logic and mathematics. To increase the accuracy of the data, the Anambra State River Basin Development Authorities must intensify record-keeping activities.
Penerapan Metode Costumer Relationship Management Pada Fitur Sistem Penjualan Produk Kecantikan Berbasis Web (Studi Kasus: Toko Id.Maskmask)
Authors: Wulandari Maria  Sri , Noveandini Rahayu 
Published: May 2023

Id.Maskmask ini merupakan sebuah toko yang menjual berbagai alat kecantikan berupa masker, body lotion, body scrub, serum, dan face mist. Saat ini penjualan produk kecantikan yang diterapkan toko Id.Maskmask masih menggunakan metode lama yaitu media WhatsApp sebagai media pemesanan dan Instagram sebagai media promosi untuk menawarkan produk dan promosi kepada konsumen serta mempermudah hubungan antara penjual dan pembeli, maka perlu dibuatnya webiste untuk melakukan transaksi, laporan penjualan dan ruang ulasan atau komentar untuk mengetahui kepuasan konsumen terhadap produk toko Id.Maskmask. Dalam membangun sistem ini menggunakan metode Costumer Relationship Management (CRM) dan proses perancangan ini menggunakan Struktur Navigasi dan UML (Unified Modeling Language). Pada pembuatan aplikasi menggunakan bahasa pemrograman (HTML, PHP, CSS, JavaScript), jQuery sebagai library, MySQL atau phpMyAdmin sebagai database, dan Bootstrap sebagai framework. Dari dua media yang telah dilakukan uji coba (Laptop dan Smartphone) aplikasi ini berjalan baik pada penggunaan laptop dengan browser google chrome dan microsoft edge. Sedangkan penggunaan smartphone secara tampilan tidak responsive rapih dari segi tata letak tombol namun fungsi dan kegunaannya normal dengan browser google chrome dan peramban web. Aplikasi ini akan mempermudah pelanggan dalam pemesanan dan bertransaksi serta memberi ulasan terhadap toko mengenai kepuasan konsumen terhadap produk dengan aman kapanpun dan dimanapun.
Analisa Sentimen Terhadap Twitter IndihomeCare Menggunakan Perbandingan Algoritma Smote, Support Vector Machine, AdaBoost dan Particle Swarm Optimization
Authors: Syah Ferdian , Fajrin Hanif , Afif Abiyyu Nur , Saeputra Muhamad Rafi , Mirranty Dinda , Saputra Dedi Dwi 
Published: May 2023

Indihome merupakan salah satu dari sekian internet service provider terbesar di Indonesia dengan peningkatan pelanggan setiap tahunnya. Pelanggan Indihome hingga akhir Maret 2022 tercatat mencapai 8,7 juta, tumbuh 7,2 persen dibanding periode yang sama tahun lalu. Namun, seiring berjalannya waktu, banyak pelanggan yang melayangkan keluhan kepada IndiHome mengenai lambatnya akses internet, kenaikan billing secara tiba-tiba dan lain sebagainya. Berdasarkan deskripsi di atas maka menarik untuk melakukan penelitian penggunaan Indihome tweet yang merupakan hasil dari penyaluran opini dan komentar di sosial media twitter. Penelitian ini menggunakan metode Smote, Support vector machine, Adaboost dan Particle swarm optimization agar hasil tersebut dapat dibandingkan tingkat keakurasiannya. Hasil dari penilitian ini didapat bahwa dengan menggunakan metode Smote, Support vector machine didapat nilai Accuracy 80.48, Precision 85.29, Recall 73.75 dan AUC 0.907. Sedangkan untuk metode Smote, Support vector machine dan AdaBoost didapat nilai Accuracy 80.21, Precision 85.01, Recall 73.36 dan AUC 0.861. Terakhir, hasil dari metode metode Smote dan Particle swarm optimization didapat nilai Accuracy 76.59, Precision 76.57, Recall 80.35 dan AUC 0.868. Berdasarkan hasil peneltian, metode Smote dan Support vector machine (SVM) mempunyai hasil terbesar dan dinilai efektif dengan dataset yang ada
Implementasi Pendidikan Akhlak Santri PPT Al-Hamidiyah NW Kediri Lombok Barat NTB
Authors: Jauhari Ahmad Thontowi , Jamaluddin Jamaluddin , Saladin Bustami 
Published: May 2023

Education has a very important role, even its position in religion becomes an obligation. One of the most important educational roles in human life is moral education. Moral education has always been a major problem that has plagued humanity throughout history. The objectives of this study are 1) To know the concept of the moral education program for students of PPT Al-Hamidiyah NW Kediri. 2) Knowing the implementation of the moral education of students of PPT Al-Hamidiyah NW Kediri 3) Knowing what are the obstacles encountered in implementing the moral education of students of PPT Al-Hamidiyah NW Kediri and their solutions. The method used in this research is a descriptive qualitative method. Data collection techniques through observation, interviews and documentation. While the research location is centered on the Al-Hamidiyah Integrated Islamic Boarding School, NW Kediri, West Lombok. The results of the study are: 1) The concept of the moral education program at PPT Al-Hamidiyah NW Kediri is in the form of intra curricular and extracurricular program activities, as well as the daily activities of the students, 2) The implementation of the moral education of students at PPT Al-Hamidiyah NW Kediri is divided into three stages, namely the stages: (a) Planning (b) Implementation and (c) Evaluation (3) The obstacles encountered in implementing the santri moral education at PPT Al-Hamidiyah NW Kediri include laziness, difficulty gathering during planning meetings, limited infrastructure. sudden event invitations, diverse student backgrounds, the impact of increasingly uncontrolled technological advances, psychological factors, the lack of openness of the asatidz board in expressing their opinions during evaluation meetings, and the busy life of the pesantren leaders. The solution is to collaborate with all parties, prepare back-up asatidz, look for a khos youth for transferring students and provide punishment for rule breakers.
Comparative chromosome mapping of repetitive DNA in four minnow fishes (Cyprinidae, Cypriniformes)
Authors: Aiumsumang Surachest , Chaiyasan Patcharaporn , Khoomsab Kan , Supiwong Weerayuth , Tanomtong Alongklod , Phimphan Sumalee 
Published: May 2023

The present study focused on the repetitive DNA of the chromosome in four minnow fishes from the genera Danio Hamilton, 1822, Devario Heckel, 1843 and Rasbora Bleeker, 1859. Chromosomes were analysed using fluorescence in situ hybridization (FISH) with microsatellite probes including (CA)15, (CAC)10, (CGG)10, (GC)15 and (TA)15 staining. All species retained the diploid chromosome number 2n = 50 in male and female. The microsatellite sequences were mapped in the chromosomes of Danio albolineatus (Blyth, 1860), Devario regina (Fowler, 1934), Rasbora aurotaenia Tirant, 1885 and R. paviana Tirant, 1885. In most cases, the microsatellite was dispersed in the chromosome with conspicuous markings in the telomeric region and the whole genome, which suggests that sequences contribute to chromosome structure and may have played a role in the relationship of this fish group. The comparative genome mapping data presented here provide novel information on the structure and organisation of the repetitive DNA region of the minnow’s genome and contribute to a better understanding of the genomes of these minnows.
Diagnosis on social impact measurement in the Matanzas science and technology park
Authors: Villalonga Arencibia Yoandy Sergio , Tarifa Lozano Lourdes , Artola Pimentel María de Lourdes , González Palmira Edith Adolfina , Acosta González Yudith , Finalé de la Cruz Leyda 
Published: May 2023

The current Cuban context evidences a boom in research projects involving science, technology and innovation. Our National Innovation Management System is focused on the solution of the problems presented by our socialist social development economic model, with the use of knowledge and innovation. As part of the Informatization Policy of the country, the Scientific and Technological Parks (PCT) arise in Cuba, with which an accelerated development of R+D+i projects is propitiated in order to solve the fundamental problems of this model.
At the express request of the country’s management, the projects generated by the PCTs in order to fulfill their mission and social transformation, it is essential to measure their social impact; however, the review of their design and a diagnosis (using methods such as surveys, interviews, documentary analysis) of the skills of the project managers working in the PCTCs, show marked weaknesses in measuring the social impact of their projects, which is the main objective of the present work: to show the results of the diagnosis carried out from the definition of indicators and measurement criteria for this purpose, as well as the authors’ analysis of the possible ways of solution.