bluuebunny/crossref_metadata_2025_split huggingface dataset:
STRATEGI KOPING FOKUS EMOSI MAHASISWA PADA MASA PANDEMI COVID-19
Authors: Ihsan Firman Maulana , Sulistyowati Muji , Qomaruddin Mochammad Bagus , Deviatin Nafiatus Sintya , Nurmala Ira 
Published: June 2023

COVID-19 adalah sebuah pandemi yang mematikan dan menimbulkan banyak kerugian. Salah satu langkah pencegahan oleh pemerintah adalah melakukan lockdown dan menerapkan pembelajaran online untuk anak sekolah dan perkuliahan. Hal ini menimbulkan potensi stres pada remaja. Tujuan dari studi ini adalah mengetahui faktor yang mempengaruhi remaja melakukan koping stres yang terfokus pada emosinya atau Emotion Focused Coping (EFC). Studi ini merupakan studi kuantitatif dengan menggunakan desain penelitian cross sectional dengan uji statistik yang digunakan adalah regresi logistik dengan metode backward. Responden berjumlah 397 mahasiswa aktif jenjang Diploma dan Sarjana di Universitas Airlangga angkatan 2017 hingga 2020. Penelitian ini dilakukan pada bulan April 2020 hingga Februari 2021. Sampel dipilih dengan simple random sampling. Teknik pengumpulan penelitian menggunakan Online Survey menggunakan fitur Google Form. Hasil dari studi ini menunjukkan bahwa faktor causal focus, controlled by self dan controlled by others memiliki korelasi signifikan terhadap EFC, masing-masing bernilai p-value = 0,003, p-value = 0,018 dan p-value = 0,009. Kesimpulan dalam studi ini adalah remaja melakukan Emotion Focused Coping karena menyadari kemampuannya untuk mengatasi potensi stres akibat COVID-19 dari dalam diri sendiri maupun bantuan orang lain dan perilaku menyalahkan diri sendiri. Peneliti selanjutnya diharapkan dapat meneliti mengenai dampak dari remaja yang tidak bisa mengontrol koping fokus emosi terhadap kesehatan mentalnya sebagai mahasiswa di masa pandemi COVID-19.
ANALISIS SENSORI TERHADAP MINUMAN KOPI CELUP REMPAH YANG DISUKAI PANELIS
Authors: Anggia Malse , Wijayanti Ruri , Ariyetti Ariyetti 
Published: June 2023

Kopi Robusta mempunyai kualitas, cita rasa, dan harga yang tinggi dibandingkan dengan jenis kopi lain. Saat ini, terdapat trend penambahan berbagai rempah pada kopi untuk memberikan aroma dan meningkatkan selera melalui efek menyegarkan dan menghangatkan. Tujuan penelitian ini adalah untuk mengetahui kesukaan panelis terhadap minuman kopi celup dyang ditambahkan berbagai rempah. Identifikasi sensori kejernihan, rasa, aroma, dan warna terhadap minuman kopi celup rempah yang dihasilkan dengan metode hedonik. Rempah yang ditambahkan adalah jahe, sereh, kapulaga, dan cengkeh. hasil penelitian menunjukkan bahwa panelis menyukai komposisi yang berbeda di tiap jenis rempahnya, yaitu 8 g Kopi + 0,2 g jahe, 1,8 g Kopi + 0,2 g sereh, 1,5 g Kopi + 0,5 g cengkeh dan1,5 g Kopi + 0,5 g kapulaga. Namun, secara keseluruhan formulasi kopi kontrol (2,0-gram kopi bubuk) lebih disukai dibandingkan dengan kopi yang ditambahkan rempah
EFEKTIFITAS EKSTRAK DAUN SELASIH (Ocimum basilicum L.) DAN PANDAN WANGI (Padanus amaryliolius) UNTUK PENGENDALIAN LALAT BUAH BACTROCERA SP PADA TANAMAN CABAI (Capsicum fruescens L)
Authors: Setyaningrum Haris , Hamawi Mahmudah , Santo Bonang Asmoro 
Published: June 2023

Kemampuan ekstrak daun selasih dan pandan wangi dalam menarik kedatangan lalat buah dipengaruhi oleh kandungan bahan aktif seperti Metil Eugenol (ME) (C12H14O2). Rendeman minyak hasil perebusan daun selasih adalah 1,14% dengan kadar ME mencapai 76%. Sedangkan kadar kandungan ME dalam minyak atsiri daun pandan wangi sekitar kadar 5%. Penelitian ini bertujuan untuk mengetahui pengaruh ekstrak selasih dan pandan wangi terhadap lalat buah. Penelitian dilakukan pada buan Agustus 2019 di Kecamatan Mlarak dan Sawo, Ponorogo, Jawa Timur. Terdapat dua perlakuan yaitu ekstrak daun selasih dan daun pandan yang masing-masing diulang tiga kali. Pengambilan sampel lalat buah didapatkan dari pemasangan perangkap di delapan petak lahan. Sedangkan, pengambilan sampel buah rusak diambil dari tanaman cabai rawit. Hasil penelitian ini menunjukan bahwa ekstrak daun pandan wangi dan daun selasih mampu menarik lalat buah. Namun, ekstrak daun kemangi lebih efektif dibandingkan dengan daun pandan. Jumlah lalat buah yang tertangkap pada perlakuan ekstrak daun selasih di daerah Mlarak 116 ekor dan Sawo 83 ekor, lebih banyak dibandingkan dengan ekstrak daun pandan wangi yang berjumlah masing-masing 11 ekor di kedua lahan peneltian. Kemudian, intensitas serangan pada buah cabai paling banyak pada lahan dengan perlakuan ekstrak daun pandan mencapai 33.74% di Mlarak dan 29.61% di Sawo. Sedangkan spesies lalat buah yang tertangkap ialah betina dari B. carambolea, B. umbrosa, dan B. fuscitibia.
Treeline displacement may affect lake dissolved organic matter processing at high latitudes and altitudes
Authors: Peter Hannes , Catalán Núria , Rofner Carina , Verpoorter Charles , Perez Maria Teresa , Dittmar Thorsten , Tranvik Lars , Sommaruga Ruben 
Published: June 2023

Abstract
Climate change is causing a rapid shift in treeline position, both towards higher altitudes and latitudes1 inducing changes in soil properties such as organic matter content and composition2. Eventually, soil-derived organic matter is transported to alpine and subarctic lakes with yet unknown consequences for dissolved organic matter diversity and processing. Here, we experimentally investigated the consequences of treeline shifts by amending subarctic and temperate alpine lake water with soil-derived dissolved organic matter (DOM) from above and below the treeline. We used ultra-high resolution mass spectrometry (FT-IR MS) to track molecular DOM diversity (i.e., chemodiversity), estimated DOM decay and measured bacterial growth efficiency. In both lakes, soil-derived DOM from below the treeline increased DOM chemodiversity mainly through the enrichment with novel polyphenolic and highly unsaturated compounds. These compositional changes were associated with reduced overall and compound-level DOM reactivity and reduced bacterial growth efficiency. Our results suggest that treeline advancement has the potential to enrich a large number of lake ecosystems with less biodegradable DOM, affecting bacterial community function and potentially altering the biogeochemical cycling of carbon in lakes at high latitudes and altitudes.
Nystagmus in children with primary brain tumors in Denmark between 2007 and 2017
Authors: Rosenberg Jacqueline , Nissen Kamilla , Heegaard Steffen , Ragunathan Suganiah , Schmiegelow Kjeld , Mathiasen René , von Holstein Sarah 
Published: June 2023

Abstract
Background
The aim of the study was to evaluate the prevalence, clinical characteristics, and diagnostic importance of nystagmus in children with brain tumors.
Methods
A nation-wide retrospective review of all children diagnosed with a brain tumor between January the 1st, 2007 and December 31st, 2017, in Denmark. Data is based on information from the Danish Childhood Cancer Registry, hospital records from pediatric- and ophthalmological departments, and records from private ophthalmologists.
Results
Nystagmus was observed in 13.7% (60/437) of children with a brain tumor. In 50/60 children (83.3%) nystagmus was an incidental finding at the clinical examination and only in 10/60 children (16,7%) were nystagmus noticed by patient/caregivers prior to the clinical examination. In 38/60 children nystagmus was observed before the brain tumor diagnosis, most often (16/38, 42%) the same day as the diagnosis was made. In 22/60 children nystagmus was found after the brain tumor diagnosis (prior to any treatment) with a median of four days (range 0–47) after the brain tumor diagnosis. Nystagmus was most commonly binocular (56/60, 93.3%) and gaze-evoked (43/60, 71.7%). The median number of additional symptoms and/or clinical findings was five (range 0–11).
Conclusion
Nystagmus is frequent in children with brain tumors and is typically accompanied by other symptoms and clinical signs. However, it is often first recognized by the ophthalmologist late in the time course. Therefore, awareness of nystagmus and the importance to test for gaze-evoked forms might contribute to increased suspicion of brain tumor and thereby faster diagnosis.
Analgesic efficacy and impact of pudendal block on surgery in children: a systematic review and meta-analysis
Authors: Xu Le , Yang Taoran , Wang rurong , Chen Yali , Ji Peng 
Published: June 2023

Abstract
Background
Both hypospadias and circumcision are common genital surgeries in pediatric patients who that can cause serious postoperative pain and have long-term effects.Pudendal block (PNB) has recently been studied in children undergoing both hypospadias surgery and circumcision.
Objective
We sought to perform a meta-analysis to estimate the analgesic efficacy, relative complications and satisfaction of pudendal block for hypospadias repair and circumcision in children.
Evidence Review
We identified comparative studies of pudendal block versus dorsal penile nerve block (DPNB) or caudal blocks (CB); studies were published or presented through 31 December 2021. Data were abstracted from studies comparing pudendal block versus dorsal penile nerve block (DPNB) or caudal blocks (CB). Original source data were used when available. Data from 298 patients in four RCTs were included.
Findings
Compared with traditional nerve blocks, the pudendal nerve block group showed no detectable difference in terms of patients who needed additional analgesia within 24 hours after the surgery (OR 0.12; p=0.09)or at 30 min(OR 0.10; p=0.13). However, it showed that fewer people needed additional analgesia at 18 h (OR 0.02; p＜0.0001) and at 12 h (OR 0.02; p=0.0001). Limited data showed that fewer people needed additional analgesia at 6 h (OR 0.03; p<0.00001), 1 h (OR 0.11; p=0.04), and 5 min (OR 0.05; p=0.0004). Compared with traditional nerve blocks, the pudendal nerve block group showed no detectable difference in terms of postoperative complications (OR 0.19; p=0.13). Compared with traditional nerve blocks, the pudendal nerve block group had better surgical satisfaction (OR 8.71; p=0.0001) and parent satisfaction (OR 12.52; p＜0.00001).
Conclusions
Compared with traditional blocking methods (CB and DNPB), for pediatric penile surgery, it hasshown that pudendal nerve block has better early postoperative analgesia and better surgical satisfaction and parental satisfaction with no obvious postoperative complications.
Classification of the Equatorial Plasma Bubbles Using Convolutional Neural Network and Support Vector Machine Techniques
Authors: Thanakulketsarat Thananphat , Supnithi Pornchai , Myint Lin Min Min , Hozumi Kornyanat , Nishioka Michi 
Published: June 2023

Abstract
Equatorial Plasma Bubble (EPB) is a phenomenon characterized by depletions in ionospheric plasma density being formed during post-sunset hours. The irregularities can lead to disruptions in trans-ionospheric radio systems, navigation systems and satellite communications. Real-time detection and classification of EPBs are crucial for the space weather community. Since 2020, the Prachompklao Radar station, a very high frequency (VHF) radar station, has been installed at Chumphon station (Geographic: 10.72°N, 99.73°E and Geomagnetic: 1.33°N) and started to produce radar images ever since. In this work, we propose two real-time plasma bubble detection systems based on support vector machine techniques. Two designs are made with the convolutional neural network (CNN) and singular value decomposition (SVD) used for feature extraction, the connected to the support vector machine (SVM) for EPB classification. The proposed models are trained using quick look (QL) plot images from the VHF radar system at the Chumphom station, Thailand, in 2017. The experimental results show that the combined CNN-SVM model, using the RBF kernel, achieves the highest accuracy of 93.08% while the model using the polynomial kernel achieved an accuracy of 92.14%. On the other hand, the combined SVD-SVM models yield the accuracies of 88.37% and 85.00% for RBF and polynomial kernels of SVM, respectively.
SLE Antibody-Secreting Cells Are Characterized by Enhanced Peripheral Maturation and Survival Programs
Authors: Sanz Ignacio , Chen Weirong , Hong So-Hee , Jenks Scott , Anam Fabliha , Tipton Christopher , Woodruff Matthew , Hom Jennifer , Cashman Kevin , Faliti Caterina , Wang Xiaoqian , Kyu Shuya , Wei Chungwen , Scharer Chris , Mi Tian , Hicks Sakeenah , Hartson Louise , Nguyen Doan , Khosroshahi Arezou , Lee Saeyun , Wang Youliang , Bugrovsky Regina , Ishii Yusho , Lee Frances 
Published: June 2023

Abstract
Systemic Lupus Erythematosus (SLE) is an autoimmune disease characterized by multiple autoantibodies, some of which are present in high titers in a sustained, B cell-independent fashion consistent with their generation from long-lived plasma cells (LLPC). Active SLE displays high numbers of circulating antibody-secreting cells (ASC). Understanding the mechanisms of generation and survival of SLE ASC would contribute important insight into disease pathogenesis and novel targeted therapies. We studied the properties of SLE ASC through a systematic analysis of their phenotypic, molecular, structural, and functional features. Our results indicate that in active SLE, relative to healthy post-immunization responses, blood ASC contain a much larger fraction of newly generated mature CD19- CD138+ ASC similar to bone marrow (BM) LLPC. SLE ASC were characterized by morphological and structural features of premature maturation. Additionally, SLE ASC express high levels of CXCR4 and CD138, and molecular programs consistent with increased longevity based on pro-survival and attenuated pro-apoptotic pathways. Notably, SLE ASC demonstrate autocrine production of APRIL and IL-10 and experience prolonged in vitro survival. Combined, our findings indicate that SLE ASC are endowed with enhanced peripheral maturation, survival and BM homing potential suggesting that these features likely underlie BM expansion of autoreactive PC.
The exact solutions to a new type space reverse nonlocal Lakshmanan-Porserzian-Daniel equation
Authors: Song Caiqin , Fang Ri-Rong , Zhang Hui-Li , Zhao Hai-qiong 
Published: June 2023

Abstract
In this paper, we study a new type space reverse nonlocal Lakshmanan-Porserzian-Daniel (LPD) equation which can be derived from the two component LPD system with a special reduction. We construct the multi-fold binary Darboux transformation for this equation and obtain lots of exact solutions with zero and non-zero background condition. We find that these solutions exhibit various dynamic evolutions, and most of the collisions between the waves in these solutions are inelastic.
TFEB SUMOylation in macrophages accelerates atherosclerosis by promoting the formation of foam cells through inhibiting lysosomal activity
Authors: Wang Kezhou , Zhou Wei , Hu Gaolei , Wang Lifeng , Cai Rong , Tian Tian 
Published: June 2023

Abstract
Atherosclerosis (AS) is a serious cardiovascular disease. One of its hallmarks is hyperlipidemia. Inhibiting the formation of macrophage foam cells is critical for alleviating AS. Transcription factor EB (TFEB) can limit the formation of macrophage foam cells by up-regulating lysosomal activity. We examined whether TFEB SUMOylation is involved in this progress during AS. In this study, we investigated the role of TFEB SUMOylation in macrophages in AS using TFEB SUMOylation deficiency Ldlr−/− (TFEB-KR: Ldlr−/−) transgenic mice and TFEB-KR bone marrow–derived macrophages. We observed that TFEB-KR: Ldlr−/− atherosclerotic mice had thinner plaques and macrophages with higher lysosomal activity when compared to WT: Ldlr−/− mice. TFEB SUMOylation in macrophages decreased after oxidized low-density lipoprotein (OxLDL) treatment in vitro. Compared with wild type macrophages, TFEB-KR macrophages exhibited less lipid deposition after OxLDL treatment. Our study demonstrated that in AS, deSUMOylation of TFEB could inhibit the formation of macrophage foam cells through enhancing lysosomal biogenesis and autophagy, further reducing the accumulation of lipids in macrophages, and ultimately alleviating the development of AS. Thus, TFEB SUMOylation can be a switch to modulate macrophage foam cells formation and used as a potential target for AS therapy.
Forty Years of Monitoring Increasing Sea Turtle Abundance in the Gulf of Mexico
Authors: Lasala Jacob , Macksey Melissa C , Mazzarella Kristen T , Main Kevan L , Foote Jerris J , Tucker Anton D 
Published: June 2023

Abstract
Longitudinal data sets for population abundance are essential for studies of imperiled organisms with long life spans or migratory movements, such as marine turtles. Population status trends are crucial for conservation managers to assess recovery effectiveness. A direct assessment of population growth is the enumeration of nesting numbers and quantifying nest attempts (successful nests / unsuccessful attempts) and emergence success (number of hatchlings leaving the nest) because of the substantial annual variations due to nest placement, predation, and storm activity. We documented over 133,000 sea turtle crawls for 50.9 km (31.5 miles) of Florida Gulf of Mexico coastline from 1982–2021 for a large loggerhead turtle nesting aggregation and a recovering remnant population of green sea turtles. Nest counts and hatchling production for both species have significantly increased, but emergence success has not. Sea level rise and coastal developments undoubtedly influence habitats in the long-term, impacting nest site selection and potential recruitment from the loss of emerged hatchlings. However, the present indications for steady Gulf of Mexico recovery of loggerhead and green sea turtles and range expansions of Kemp’s ridley and leatherback turtles parallel findings of the Florida Atlantic coasts. This study indicates that effective conservation practices can be detected within time scales of 1–2 turtle generations.
Tricuspid Balloon Valve Fracture and Valve-in-Valve-in-Valve in a patient with Tetralogy of Fallot
Authors: Challa Abhinay , Appadurai Vinesh , Wijesekera Vishva , Raffel Christopher , Scalia Gregory , Walters Darren , Poon Karl , Murdoch Dale 
Published: June 2023

Abstract
Background
Tetralogy of Fallot is the most common form of cyanotic congenital heart disease, with patients often requiring repeated valvular interventions throughout their lifetime. Transcatheter intervention play an important role in this cohort, and have been incorporated into guidelines for the management of prosthetic pulmonary valve degeneration, with growing observational data of transcatheter procedures in the tricuspid position. Here we describe a patient with Tetralogy of Fallot where transcatheter procedures were utilized in a patient of high surgical risk.
Case presentation
A 32 year old female with a history of repaired Tetralogy of Fallot presented with treatment resistant right sided heart failure. She had previously undergone four sternotomies, resulting in a 31mm Mosaic valve in the tricuspid position, and a 25mm homograft in the pulmonary position. She had also underwent a tricuspid valve in valve procedure for severe bioprosthetic valve stenosis, which had re-stenosed after 4 years. She was discussed in a multidisciplinary meeting, and given her multiple previous sternotomies and morbid obesity, decision was made to attempt further percutaneous intervention. She successfully underwent a Tricuspid Valve-in-Valve-in-Valve procedure with a 29mm Sapien 3 valve. Six month follow up demonstrated favourable valve hemodynamics, along with improvement in symptoms of right sided heart failure.
Conclusions
Transcatheter procedures have had an evolving role in the management of patients with congenital heart disease. This case highlights the utility of transcatheter interventions in a patient of very high surgical risk. Although the long term durability of these interventions are yet to be determined in the literature, they play an important role in prolonging the lifespan of a surgical valve, which in turn reduces the total sternotomies patients undergo over their lifetime.
Exploring the Diagnostic Value of Ultrasound Radiomics for Neonatal Respiratory Distress Syndrome
Authors: Lin Weiru , Ruan Junxian , Liu Zhiyong , Liu Caihong , Wang Jianan , Chen Linjun , Zhang Weifeng , Lyu Guorong 
Published: June 2023

Abstract
Background: Neonatal respiratory distress syndrome (NRDS) is a prevalent cause of respiratory failure and death among newborns, and prompt diagnosis is imperative. Historically, diagnosis of NRDS relied mostly on typical clinical manifestations, chest X-rays, and CT scans. However, recently, ultrasound has emerged as a valuable and preferred tool for aiding NRDS diagnosis. Nevertheless, evaluating lung ultrasound imagery necessitates rigorous training and may be subject to operator-dependent bias, limiting its widespread use. As a result, it is essential to investigate a new, reliable, and operator-independent diagnostic approach that does not require subjective factors or operator expertise. This article aims to explore the diagnostic potential of ultrasound-based radiomics in differentiating NRDS from other non-NRDS lung disease.
Methods: A total of 150 neonatal lung disease cases were collected between September 2021 and October 2022. Of these patients, 60 were diagnosed with NRDS, whereas 30 were diagnosed with neonatal pneumonia, meconium aspiration syndrome (MAS), and transient tachypnea (TTN). Two ultrasound images with characteristic manifestations of each lung disease were acquired and divided into training (n=120) and validation cohorts (n=30) based on the examination date using an 8:2 ratio. The imaging texture features were extracted using PyRadiomics and, after the screening, machine learning models such as random forest (RF), logistic regression (LR), K-nearest neighbors (KNN), support vector machine (SVM), and multilayer perceptron (MLP) were developed to construct an imaging-based diagnostic model. The diagnostic efficacy of each model was analyzed.
Results: Twenty-two imaging-based features with the highest weights were selected to construct a predictive model for neonatal respiratory distress syndrome. All models exhibited favorable diagnostic performances. Analysis of the Youden index demonstrated that the RF model had the highest score in both the training (0.99) and validation (0.90) cohorts. Additionally, the calibration curve indicated that the RF model had the best calibration (P=0.98). When compared to the diagnostic performance of experienced and junior physicians, the RF model had an area under the curve (AUC) of 0.99; however, the values for experienced and junior physicians were 0.98 and 0.85, respectively. The difference in diagnostic efficacy between the RF model and experienced physicians was not statistically significant (P=0.24), whereas that between the RF model and junior physicians was statistically significant (P<0.0001).
Conclusion: The RF model exhibited excellent diagnostic performance in the analysis of texture features based on ultrasound radiomics for diagnosing NRDS.
A high-efficient protoplast transient system for screening gene editing elements in Salvia miltiorrhiza
Authors: Shao Jin , Peng Bowen , Zhang Yaojie , Yan Xin , Yao Xinghao , Hu Xinyi , Li Ling , Fu Xueqing , Zhen Han , Tang Kexuan 
Published: June 2023

Abstract
Medicinal plants with high-value pharmaceutical ingredients have attracted research attention due to their beneficial effects on human health. Cell wall-free protoplasts of plants can be used to evaluate the efficiency of genome editing mutagenesis. The capabilities of gene editing in medicinal plants remain to be fully explored owing to their complex genetic background and shortfall of suitable transformation. Here, we took the Salvia miltiorrhiza as a representative example for developing a method to screen favorable gene editing elements with high editing efficiency in medical plants by a PEG-mediated protoplast transformation. Results indicated that using the endogenous SmU6.1 of Salvia miltiorrhizato drive sgRNA and the plant codon-optimized Cas9 driven by the promoter SlEF1αcan enhance the efficiency of editing. In summary, we uncover an efficacious transient method for screening editing elements and shed new light on increasing gene editing efficiency in medicinal plants.