bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recurrent marine heatwaves threaten the resilience and viability of a key Mediterranean octocoral species
Authors: Orenes‐Salazar Víctor , Navarro‐Martínez Pedro Clemente , Ruíz Juan Manuel , García‐Charton José Antonio 
Published: August 2023

Abstract

Long‐term ecological studies are essential for understanding the resilience of temperate reefs to ocean warming and the response of their habitat‐forming species to recurrent marine heatwaves (MHWs).
This study evaluated the long‐term response (2005–2021) of the habitat‐forming octocoral Eunicella singularis (Esper, 1791) to recurrent MHWs in a Mediterranean marine protected area established more than 25 years ago, where restrictions on fishing and diving activities are well enforced.
During the study period, there were two mass‐mortality events (MMEs), in 2007 and 2018, that dramatically disrupted the local gorgonian population. The MMEs were triggered by different temperature dynamics, which ultimately led to differential patterns in mortality rates.
The record‐breaking MHW in 2018 prompted one of the largest MMEs ever recorded in the Mediterranean Sea, which affected 75% of the individuals in the gorgonian population and killed 12.5% of colonies.
Furthermore, MHWs were detected in all years from 2014 to 2021, preventing injured tissues from fully recovering, leading to significant accumulated damage at the end of the study period (30 times higher than the levels prior to the first MME), and a marked decrease in resilience that threatens the population viability of this long‐lived species.
The octocoral studied is one of the most important structural and biomass contributors to one of the most diverse Mediterranean communities. These results underscore the great risk that annual MHWs pose to the long‐term integrity of the circalittoral rocky bottoms of the Mediterranean coasts.
In the face of climate change, MPAs must provide areas of reduced anthropic stress for gorgonian populations, enabling the restoration and maintenance of natural processes. Additionally, MPAs should serve as sentinel areas to test the effectiveness of coral restoration actions, which can help managers and scientists to estimate the usefulness of these techniques.
Exponential stability of time‐delay systems with flexible delayed impulse
Authors: Yu Zheqi , Ling Song , Liu Peter X. 
Published: August 2023

AbstractThe problem of exponential stability for time‐delay systems with flexible delayed impulse control is investigated. Unlike the conventional Razumikhin‐type inequality, variable parameter based on the flexible impulsive gain is introduced. Sufficient conditions for exponential stability are developed for a class of time‐delay systems, for which the size of delay is not limited by impulsive intervals. A flexible impulse control scheme is developed by utilizing the flexible impulsive gain and time‐varying delays. When the system is disturbed by the impulse interferences, both the impulse gain and impulse delay can be adjusted accordingly to make the system exponential stable. The effectiveness of the present results is illustrated by two numerical examples and an application.
The role of localised prostate cancer treatment in renal transplant patients: A systematic review
Authors: Dat Anthony , Wei Gavin , Knight Simon , Ranasinghe Weranja 
Published: August 2023

AbstractObjectiveTo systematically review and critically appraise all treatment options for localised prostate cancer in renal transplant candidates and recipients.MethodA systematic review was conducted adhering to PRISMA guidelines. Searches were performed in the Cochrane Library, Embase, Medline, the Transplant Library and Trip database for studies published up to September 2022. Risk of bias was assessed with the Cochrane Risk of Bias in Non‐Randomised Studies of Interventions for non‐randomised studies tool.ResultsA total of 60 studies were identified describing 525 patients. The majority of studies were either retrospective non‐randomised comparative or case series/reports of poor quality. The vast majority of studies were focussed on prostate cancer after renal transplantation. Overall, 410 (78%) patients underwent surgery, 93 (18%) patients underwent radiation therapy or brachytherapy, one patient underwent focal therapy (high‐intensity frequency ultrasound) and 21 patients were placed on active surveillance. The mean age was 61 years old, the mean PSA level at diagnosis was 9.6 ng/mL and the mean follow‐up time was 31 months. The majority of patients had low‐risk disease with 261 patients having Gleason 6 prostate cancer (50%), followed by 220 Gleason 7 patients (42%). All prostate cancer mortality cases were in high‐risk prostate cancer (≥Gleason 8). The cancer‐specific survival results were similar between surgery and radiotherapy at 1 and 3 years.ConclusionLocalised prostate cancer treatment in renal transplant patients should be risk stratified. Surgery and radiation treatment for localised prostate cancer in renal transplant patients appear equally efficacious. Given the limitations of this study, future research should concentrate on developing a multicentre RCT with long‐term registry follow‐up.
The development of host language achievement gaps by migration background during primary school: A path model of educational inequalities
Authors: Sprong Stefanie , Skopek Jan 
Published: August 2023

AbstractEducation is key to the structural integration of immigrants and their children. While research indicates that educational inequalities by migration background are a serious issue, relatively little is known about when, how and why they develop. The current paper adds to the literature by investigating to what extent achievement gaps by migration background develop during the primary school period. Drawing on data from a national longitudinal study of children in Ireland (N = 7577) and using structural equation modelling, it presents a path model of host language achievement. The results indicate that a large part of the disadvantages in English language achievement by migration background during primary school could be attributed to achievement gaps that already existed before school. Moreover, given earlier achievement, the effect of having a migration background was often insignificant or even positive, suggesting that disparities remain relatively stable or even decrease during the period of formal schooling.
Synthesis of copper nanoclusters from Bacopa monnieri leaves for fluorescence sensing of dichlorvos
Authors: Sadhu Vibhuti Atulbhai , Jha Sanjay , Park Tae Jung , Kailasa Suresh Kumar 
Published: August 2023

AbstractIn this work, a facile one‐step green synthesis was developed for the fabrication of blue fluorescent copper nanocluster (Brahmi‐CuNCs) from the extract of Bacopa monnieri (common name is Brahmi) via a microwave method. The as‐prepared Brahmi‐CuNCs emitted blue fluorescence at 452 nm when excited at 352 nm and showed a quantum yield of 31.32%. Brahmi‐derived blue fluorescent CuNCs acted as a probe for fluorescence sensing of dichlorvos. Upon the addition of dichlorvos, the blue emission for Brahmi‐CuNCs was gradually turned off, favouring establishment of a calibration graph in the range 0.5–100 μM with a detection limit of 0.23 μM. The as‐synthesized Brahmi‐CuNCs exhibited marked sensitivity and selectivity towards dichlorvos, favourable for assaying dichlorvos in various samples (cabbage, apple juice, and rice).
“Not wanting to see it is hypocrisy, it's denying what is obvious”: Far‐right discriminatory discourses mobilised as common sense
Authors: Garcia‐Jaramillo Daniel , Santos Tânia R. , Fernandes‐Jesus Maria 
Published: August 2023

AbstractThe far‐right recently entered the Portuguese parliament with the election of André Ventura, leader of the political party Chega. Since 2019, Chega has grown exponentially and has become the third political force. This study aimed to explore how Ventura represents different members of Portuguese society. We examine what meanings are reproduced to configure social representations about different category groups, adopting Critical Discourse Analysis tools to explore how they were mobilised as legitimate. We analysed 253 posts shared by Ventura on Facebook, Twitter, and Instagram from the 22nd of December 2020 to the 22nd of January 2021, a month before the 2021 presidential elections. Our analysis suggests that Ventura represents a reality in which only he can save the “good Portuguese” from the threats of three main enemies: Roma people, Black people, and so‐called “antifascist” activists. We discuss how those representations relate to what has been found in other contexts and their implications for the promotion of discrimination and marginalisation of these groups in Portugal. We also point out the potential benefits of integrating Critical Discourse Analysis methodological tools for the development of the Theory of Social Representations. Please refer to the Supplementary Material section to find this article's Community and Social Impact Statement.
The influence of targeted digital advertising on consumers' purchase intention: Comparative analysis based on the perspective of ads content source
Authors: Han Zhao , Du Gang 
Published: August 2023

AbstractTargeted digital advertising (TDA) is immensely popular among marketing practitioners; investigating its effects is increasingly becoming a subject of academic research. Brands can push advertisements of the same product from different sources to consumers in a targeted manner; however, the differences in the impact on consumers of TDA with different content sources are surprisingly understudied. Therefore, this study analyzes the consumers' purchase intentions in the context of TDA with different content sources (stars vs. bloggers vs. top e‐commerce streamers), and the perceived differences between consumers with different thinking styles. Through two experimental studies, this study finds that TDA with top e‐commerce streamers' recommendation source can better improve consumers' purchase intentions more than TDA with a star endorsement and TDA with a blogger evaluation. For consumers who prefer the rational thinking style, TDA with a star endorsement and TDA with top e‐commerce streamers recommendation can be better; For consumers who prefer the empirical thinking style, TDA recommended by bloggers and TDA with top e‐commerce streamers recommendation can be better. Furthermore, this study finds that consumers' mental simulation and perceived usefulness can mediate the relationships described above, and that the two play a chain mediation role. The findings contribute to the precision marketing literature by enriching the understanding of the psychological mechanism underlying consumers' perceptions of and decision factors toward the TDA.
The miR‐302/367 cluster: Aging, inflammation, and cancer
Authors: Li Zhou , Duan Yan , Yan Shaofu , Zhang Yao , Wu Yunxia 
Published: August 2023

AbstractMicroRNAs (miRNAs) are a class of noncoding RNAs that occupy a significant role in biological processes as important regulators of intracellular homeostasis. First, we will discuss the biological genesis and functions of the miR‐302/367 cluster, including miR‐302a, miR‐302b, miR‐302c, miR‐302d, and miR‐367, as well as their roles in physiologically healthy tissues. The second section of this study reviews the progress of the miR‐302/367 cluster in the treatment of cancer, inflammation, and diseases associated with aging. This cluster's aberrant expression in cells and/or tissues exhibits similar or different effects in various diseases through molecular mechanisms such as proliferation, apoptosis, cycling, drug resistance, and invasion. This article also discusses the upstream and downstream regulatory networks of miR‐302/367 clusters and their related mechanisms. Particularly because studies on the upstream regulatory molecules of miR‐302/367 clusters, which include age‐related macular degeneration, myocardial infarction, and cancer, have become more prevalent in recent years. MiR‐302/367 cluster can be an important therapeutic target and the use of miRNAs in combination with other molecular markers may improve diagnostic or therapeutic capabilities, providing unique insights and a more dynamic view of various diseases. It is noted that miRNAs can be an important bio‐diagnostic target and offer a promising method for illness diagnosis, prevention, and treatment.
On the Role of Temperature in the Depolymerization of PET by FAST‐PETase: An Atomistic Point of View on Possible Active Site Pre‐Organization and Substrate‐Destabilization Effects
Authors: Orlando Carla , Prejanò Mario , Russo Nino , Marino Tiziana 
Published: August 2023

AbstractEnzyme FAST‐PETase, recently obtained by a machine learning approach, can depolymerize poly(ethylene terephthalate) (PET), a synthetic resin employed in plastics and in clothing fibers. Therefore it represents a promising solution for the recycling of PET‐based materials. In this study, a model of PET was adopted to describe the substrate, and all‐atoms classical molecular dynamics (MD) simulations on apo‐ and substrate‐bound FAST‐PETase were carried out at 30 and 50 °C to provide atomistic details on the binding step of the catalytic cycle. Comparative analysis shed light on the interactions occurring between the FAST‐PETase and 4PET at 50 °C, the optimal working conditions of the enzyme. Pre‐organization of the enzyme active and binding sites has been highlighted, while MD simulations of FAST‐PETase:4PET pointed out the occurrence of solvent‐inaccessible conformations of the substrate promoted by the enzyme. Indeed, neither of these conformations was observed during MD simulations of the substrate alone in solution performed at 30, 50 and 150 °C. The analysis led us to propose that, at 50 °C, the FAST‐PETase is pre‐organized to bind the PET and that the interactions occurring in the binding site can promote a more reactive conformation of PET substrate, thus enhancing the catalytic activity of the enzyme.
Improved Cytotoxicity and Induced Apoptosis in HeLa Cells by Co‐loading Vitamin E Succinate and Curcumin in Nano‐MIL‐88B‐NH2
Authors: Alavijeh Roya Karimi , Akhbari Kamran 
Published: August 2023

AbstractOne of the strategies for improved therapeutic effects in cancer therapy is combination chemotherapy. In this study, a flexible nano‐MOF (Fe‐MIL‐88B‐NH2) was synthesized in a sonochemical process, then co‐loaded with α‐tocopheryl succinate (TOS) and curcumin (CCM). The anticancer activity of co‐loaded Fe‐MIL‐88B‐NH2 (Fe‐MIL‐88B‐NH2/TOS@CCM) against the HeLa cells was compared with that of the single‐loaded counterpart (Fe‐MIL‐88B‐NH2@CCM). MTT analysis indicates improved cytotoxicity of Fe‐MIL‐88B‐NH2/TOS@CCM. The data from the cell apoptosis assay indicated more apoptosis in the case of the co‐loaded nano‐MOF. This study indicates the positive effect of the presence of TOS on enhancing the anticancer effect of Fe‐MIL‐88B‐NH2@CCM to prepare a more efficient drug delivery nanosystem.
A comprehensive analysis of cell‐autonomous and non‐cell‐autonomous regulation of myeloid leukemic cells: The prospect of developing novel niche‐targeting therapies
Authors: Pendse Shalmali , Chavan Sayali , Kale Vaijayanti , Vaidya Anuradha 
Published: August 2023

AbstractLeukemic cells (LCs) arise from the hematopoietic stem/and progenitor cells (HSCs/HSPCs) and utilize cues from the bone marrow microenvironment (BMM) for their regulation in the same way as their normal HSC counterparts. Mesenchymal stromal cells (MSCs), a vital component of the BMM promote leukemogenesis by creating a protective and immune‐tolerant microenvironment that can support the survival of LCs, helping them escape chemotherapy, thereby resulting in the relapse of leukemia. Conversely, MSCs also induce apoptosis in the LCs and inhibit their proliferation by interfering with their self‐renewal potential. This review discusses the work done so far on cell‐autonomous (intrinsic) and MSCs‐mediated non‐cell‐autonomous (extrinsic) regulation of myeloid leukemia with a special focus on the need to investigate the extrinsic regulation of myeloid leukemia to understand the contrasting role of MSCs in leukemogenesis. These mechanisms could be exploited to formulate novel therapeutic strategies that specifically target the leukemic microenvironment.
Acute coronary syndrome in an anomalous mid‐LAD right coronary artery: Don't forget to look twice before turning left
Authors: Miklin Daniel J. , Garcia‐Bengochea Youssef , Meraj Perwaiz 
Published: August 2023

AbstractA 68‐year‐old female with past medical history of hypertension, hyperlipidemia, multiple sclerosis, diverticulitis, and tobacco use presented with 1 day of atypical chest pain after a recent diverticulitis flare. Initial workup was notable for a normal electrocardiogram but elevated high sensitivity troponin T (616 ng/L). Due to persistent symptoms, the patient was given antiplatelet therapy and taken urgently to the catheterization lab where she was found to have complete occlusion of an anomalous right coronary artery branching off the mid‐left anterior descending artery. Angioplasty was performed with a drug‐eluting stent and her symptoms resolved. The patient recovered well and was discharged on appropriate medical therapy. This case demonstrates a case of acute coronary syndrome in an extremely rare coronary congenital abnormality. Further research is needed on when to be suspicious for coronary anomalies on patients presenting with myocardial infarction.
Solid variant of odontogenic keratocyst in a 22‐year‐old man: Report of a case
Authors: Aminishakib Pouyan , Jafari Azadeh , Padeganeh Tahereh 
Published: August 2023

Key Clinical MessageIn conclusion, we can focus on histologic features such as stellate reticulum, reverse polarization of basal cell layer nuclei, and luminal lamellated keratinization as distinguishing factors of ameloblastoma and SKCO. If there is any clinically doubt, molecular testing could be helpful.Abstract“Solid odontogenic keratocyst” is a rare variant of odontogenic keratocyst, which usually involves mandible. This case was presented as a unique variant of odontogenic keratocyst in an unusual site of left maxilla with extension to the maxillary sinus.
Single Crystal Layered Oxide Cathodes: The Relationship between Particle Size, Rate Capability, and Stability
Authors: van den Bergh Wessel , Karger Leonhard , Murugan Saravanakumar , Janek Jürgen , Kondrakov Aleksandr , Brezesinski Torsten 
Published: August 2023

AbstractWith the increasing demand for safer, more stable, and energy dense batteries, investigations into single crystal layered oxide cathodes have gained momentum. However, translating considerations from polycrystalline to single‐crystalline particles and their ensembles is not one‐to‐one. Lithium diffusion path length, surface, dopants and coatings, as well as the synthetic methods used take on different dimensions for single‐crystalline particles. In this concept article, we review key considerations that must be made when developing well‐performing single crystal layered oxide cathodes. We discuss how diffusion limitations can affect material stability in addition to how improvements to diffusivity can act as a method to simultaneously improve rate capability and surface stability. In addition, we briefly discuss how the unique feature of faceting and the synthetic design space for single‐crystalline particles should be conceptualized.
Mechanochemical Nickel‐Catalyzed Carbon‐Sulfur Bond Formation between Aryl Iodides and Aromatic Sulfur Surrogates
Authors: Hao Xiujia , Feng Daming , Chen Hongguang , Huang Peng , Guo Fang 
Published: August 2023

AbstractThe formation of aromatic thioethers from C−S coupling is of great importance in synthetic chemistry. Traditional solution strategies through transition‐metal catalysis generally require bulk solution, heat, and longer reaction time. Herein, a mechano‐promoted sulfenylation of aryl iodides with nickel catalysis is described. The active aromatic sulfide agents are in‐situ generated from aromatic thiol or disulfide and subsequently adapted in the nickel catalytic cycle, with a tolerance of broad substituted groups under optimized conditions. In addition to the gram‐scale synthesis that reveals the application potential of the method, the radical trapping and competitive experiments are also conducted for the mechanistic study, thus providing a plausible mechanism rationally. Furthermore, the proposed methodology is certificated as being versatile and following the green principles with ideal calculated values of green chemistry metrics, and the comparison with other approaches for C−S bond formation is also demonstrated.
Electrosynthesis of Metal–Organic Framework Films with Well‐Defined Facets
Authors: Guo Wei , Zhang Wei , Han Ning , Xie Sijie , Zhou Zhenyu , Monnens Wouter , Martinez Mora Omar , Xue Zhenhong , Zhang Xueliang , Zhang Xuan , Fransaer Jan 
Published: August 2023

AbstractThe deposition of metal–organic framework (MOF) films with defined exposed facets is important to enhance the performance of these films for, for example, catalysis or separations. In this work, MOF films with specific exposed facets are electrodeposited anodically on various substrates (e. g. on copper‐sputtered Si wafers, copper meshes, copper foams, and polypropylene membranes). The influence of the deposition parameters, including the pH of the solution, current density, concentration of linker, and solvent, on the exposed facets of the deposited MOFs was investigated. The results suggest that precise control over the supersaturation during anodic deposition is a possible strategy for synthesizing MOF crystals with well‐defined exposed facets. This approach provides a powerful toolbox for various applications requiring crystal facet control of MOF films.
Probing Water Diffusion Inside Crystals of AlPO‐5 by PFG NMR and IRM for Heat Storage Applications
Authors: Dvoyashkin Muslim , Chmelik Christian , Nonnen Thomas , Hermann Ralph , Russina Margarita , Gläser Roger 
Published: August 2023

AbstractDiffusion of water in the aluminophosphates AlPO‐5 is studied using a combination of pulsed field gradient NMR and IR microimaging. The concentration profiles measured by the latter allowed to visualize the process of water sorption and propagation into the crystals of AlPO‐5. The self‐diffusion coefficients obtained by NMR were one order of magnitude higher values compared to corrected ones from the IR microimaging study. The concentration profiles allowed to visualize the process of water sorption and propagation into the crystals of AlPO‐5. The obtained results are compared with experimental and simulation data for the water/AlPO‐5 system for the literature and discussed in the context of its potential use for heat storage applications.
Identifiability constraints in generalized additive models
Authors: Stringer Alex 
Published: August 2023

AbstractIdentifiability constraints are necessary for parameter estimation when fitting models with nonlinear covariate associations. The choice of constraint affects standard errors of the estimated curve. Centring constraints are often applied by default because they are thought to yield lowest standard errors out of any constraint, but this claim has not been investigated. We show that whether centring constraints are optimal depends on the response distribution and parameterization, and that for natural exponential family responses under the canonical parametrization, centring constraints are optimal only for Gaussian response.