bluuebunny/crossref_metadata_2025_split huggingface dataset:
Синтез цифровых фильтров Грея
Authors: Белецкий А. Я. 
Published: December 2022

Описаны преобразования цифровых сигналов по известным классическим (левосторонним) и предложенным правосторонним и составным кодам Грея. Рассмотрены прямая и обратная задача синтеза цифровых фильтров, реализующих преобразование n-разрядных сигналов в пространстве модульной матричной арифметики с основанием системы счисления по заданному составному коду Грея.
Оценка помехоустойчивости и эффективности передачи сообщений с помощью модифицированной относительной фазоамплитудной модуляции
Authors: Бронников В. Н. , Поддубняк В. И. , Лыков А. Г. 
Published: December 2022

Рассмотрен метод передачи сообщений с помощью модифицированной относительной фазоамплитудной модуляции. В его основе — использование временной дискретизации сообщения, фазовой манипуляции несущего колебания выборочными значениями, относительный метод передачи последних, ограничение спектра сигнала в полосовом фильтре. Показана возможность получения обобщенного выигрыша 3 дБ при использовании ширины спектра, равного удвоенной ширине спектра сообщения и входном отношении сигнал/шум ρ ≥ 10 дБ.
Акустооптический приемник панорамного обзора
Authors: Гасанов А. Р. 
Published: December 2022

Исследована возможность улучшения панорамного приемника, синтезированного на основе особенностей фотоупругого эффекта, в котором многоканальность и формирование гетеродинных полей обеспечивается одной дифракционной решеткой.
Performance of Planting Tools (Seed Planter) on Rice Land, Palu City, Central Sulawesi
Authors: FITRI AMALIA ANUGERAH , Syafruddin  
Published: December 2022

The application of innovation and technology in agricultural machinery in the world is one of the factors in increasing production and productivity of agricultural products. One of them is the application of agricultural machinery, namely the process of planting on agricultural land. The use of agricultural machinery at the farm level, especially planting, is still rarely carried out, as long as the availability of agricultural labor is decreasing. Most agricultural workers have entered non-productive age, while the interest of the younger generation to enter the world of agriculture is getting lower, especially conventional agriculture. Agricultural mechanization can solve this problem. The purpose of this research is to produce the performance of the seed planter in lowland rice fields. The research method uses an agrotechnical study that measures the theoretical capacity (Kt), actual working capacity (Ka), the efficiency of the seed planter's performance, and wheel slip on the seed planter. Based on the test results the average field capacity performance is 1.301 ha/hour, the test results are the actual average field capacity 0.650 ha/hour, the test results are the average efficiency of the tool performance is 50.0%, and the average slip test results wheel that is 13.75%. Factors that affect the performance test of planting tools, among others: operator skills, soil conditions, wheel slip, shape and size of planting tools, as well as the topography of a land.
Keywords: Actual Work Capacity (Ka), Theoretical Work Capacity (Kt), Efficiency, Wheel Slip, Seed Planter
A New Prediction Data Model of High-Risk COVID-19 Patient with Smart Notification (HRCP-SN) Using Machine Learning Algorithm
Authors: Yenurkar Ganesh , Mal Sandip 
Published: December 2022

Abstract
A web application designed to predict high-risk patients affected by COVID-19 runs a machine learning (ML) model at the backend to generate results. The random forest classification technique (a type of supervised ML approach) is used to predict the high-risk status of patients who are COVID-19 positive and are at the initial stage of infection. To predict high-risk patients, the model uses the patients’ current underlying health conditions, such as age, sex, diabetes, asthma, hypertension, smoking, and other factors. After data preprocessing and training, the model could predict the severity of the patient with an accuracy of approximately in 65–70%. According to some studies, random forest ML models outperform other ML models for solving the challenge of predicting unusual events such as pneumonia, hypertension, diabetes, obesity, and chronic renal disease were the most contributory variables for model implementation. This project will help patients and hospital staff make necessary decisions and actions in advance. This will help healthcare workers arrange resources and hospital areas for high-risk COVID-19 patients. Thus, this study provides an effective and optimized treatment. Using this application and suitable patient data, hospitals can predict whether a patient will require urgent care.
A new technique in posterior thoraco-lumbar implant removal surgery: Follow-up results for at least 10 years
Authors: YILMAZ Murat , ERTEM Onder , IKIZOGLU Ersin , ARSLAN Mert , ERBAYRAKTAR Serhat Resat , YUCESOY Kemal 
Published: December 2022

Abstract
Inroduction: Pedicle screw removing is not uncommon and require reoperations which is an immense burden on the patient and on the healthcare system.We aimed to describe with a novel surgical approach for the removal of posterior thoracolumbar implant in patients with symptomatic failure of the implant and present our preliminary results with this method.
Materials and Methods: This retrospective, single-center study was performed in the neurosurgery department of a university hospital. Data were gathered from the medical files of 314 patients (243 women, 77.39%; 71 men, 22.61%) with symptomatic thoracolumbar implant failure that underwent implant removal operation using our novel technique between 2010 and 2020. Symptoms, radiological findings, intraoperative findings as well as clinical outcomes were evaluated.
Results: In our series, the average age was 46.5 years (range: 21 to 84) with a mean follow-up duration of 7 years (range: 3 months to 10 years). Preoperatively, the most common symptoms were leg pain and numbness of the lower extremity. Postoperatively, no major complications were noted. Clinical progression of symptoms was avoided by surgery in all patients, while we came across removal difficulties due to screw-screwdriver mismatch in 15 of 314 surgeries (4.78%). Our novel approach allowed successful screw removal including these challenging cases.
Conclusion: We suggest our novel approach is a practical and effective for the removal of posterior thoracolumbar implant in cases with symptomatic failure attributed to screw-screwdriver mismatch. Further trials are warranted to assess the efficacy of this technique to overcome surgical problems associated with screw removal.
Comparative Study of Design of Cantilever Retaining Wall as Per ACI 318 &amp; IS 456
Authors: Kumar Puneet , Yadav Baljeet 
Published: December 2022

Abstract
Every country has its standard for the design and construction of structures. The codes have been evolved with the consent of several structure engineers having knowledge gained from several years of experience. These codes are revised periodically and amendments are made based on current research and current requirement.
The function of the design codes is to ensure safety and reliability and also specify certain essentials like minimum percentage of reinforcement, dimension of certain structures, etc. They render the task of the designer relatively easy and simple; results are often formulated in formulas and charts. The codes also ensure no conflict among the designer about dimension and design criteria of structure. Finally, they also provide some legal liability due to structural failure that can be caused by inadequate supervision and faulty material and construction.
This research paper aims to compare the design of a cantilever retaining wall using two different codes IS 456:2000 and ACI 318-05. The broad safety checks like check for overturning and check for sliding has been done using both code and also their comparison has been done. Comparison of design criteria for designing of retaining wall has also been accomplished.
Transcriptomics, metabolomics, and in silico drug predictions to prevent or treat liver damage in young and aged burn victims
Authors: Malachowska Beata , Yang Weng-Lang , Qualman Andrea , Muro Isreal , Boe Devin , Kovacs Elizabeth , Idrovo Juan-Pablo 
Published: December 2022

Abstract
Burns are a leading cause of morbidity and mortality worldwide, affecting individuals of all ages. Burns induce a systemic response affecting multiple organs where the liver is frequently damaged. Since the liver plays a critical role in metabolic, inflammatory, and immune events, a patient with impaired liver often exhibits poor outcomes. The mortality rate after burns in the elderly population is higher than in any other age group, and studies show that the liver of aged animals is more susceptible to injury after burns. Thus, understanding the liver response to burns in young and aged burn victims is fundamental to improving overall health care. Moreover, no liver-specific therapy exists to treat burn-induced liver damage highlighting a critical gap in burn injury therapeutics. In this project, we analyzed transcriptomics and metabolomics data from the liver of young and aged mice to identify mechanistic pathways and in-silico predict therapeutic targets to prevent or reverse burn-induced liver damage. Our study highlights pathway interactions and master regulators that underlie the liver response to burn injury in young and aged animals. The results reveal genes that may represent prospective hallmark signatures for liver damage, especially in the livers of aged burn victims.
Toward a Biomarker Panel measured in CNS-originating Extracellular Vesicles for Improved Differential Diagnosis of Parkinson’s Disease and Multiple System Atrophy
Authors: Taha Hash Brown , Hornung Simon , Dutta Suman , Fenwick Leony , Lahgui Otmane , Howe Kathryn , Elabed Nour , Rosario Irish del , Wong Darice Y. , Folle Aline Duarte , Markovic Daniela , Palma Jose-Alberto , Kang Un Jung , Alcalay Roy N. , Sklerov Miriam , Kaufmann Horacio , Fogel Brent L. , Bronstein Jeff M. , Ritz Beate , Bitan Gal 
Published: December 2022

Abstract
Synucleinopathies are neurodegenerative diseases characterized by accumulation of misfolded α-synuclein (α-syn) inclusions in neuronal and/or glial cells. Different synucleinopathies may affect different brain regions and cell types. In Parkinson’s disease (PD) and dementia with Lewy bodies (DLB), α-syn deposits predominantly in neuronal Lewy bodies (LBs) and Lewy neurites (LNs), whereas in multiple system atrophy (MSA), α-syn-rich glial cytoplasmic inclusions (GCIs) are found in oligodendrocytes (1). Despite differences in the underlying pathophysiology, synucleinopathies often are misdiagnosed, especially by non-experts in the early-stages, due to the overlapping clinical symptoms (2, 3).
Several studies have demonstrated the utility of measuring α-syn in neuronal EVs (nEVs) as a diagnostic biomarker for PD and atypical parkinsonian disorders (4). Recently, our group has shown that α-syn measured in both nEVs and oligodendroglial EVs (oEVs) in the same samples, and in particular the oEV:nEV α-syn concentration ratio, yielded a discriminative model distinguishing between PD and MSA with 89.8% sensitivity and 86.0% specificity and between healthy controls (HC) and MSA with 96.0% sensitivity and 84.3% specificity. In contrast, the model offered moderate separation between PD and HC – 71.4% sensitivity and 62.7% specificity (5).
Is MRI-Linac helpful in SABR treatments for liver metastases?
Authors: Tallet Agnès , Boher Jean-Marie , Tyran Marguerite , Mailleux Hugues , Piana Gilles , Benkreira Mohamed , Fau Pierre , Salem Naji , Gonzague Laurence , Petit Claire , Darréon Julien 
Published: December 2022

Abstract
Objective
To determine the MRI-Linac added value over conventional image-guided radiation therapy (IGRT) in liver tumors Stereotactic ablative radiation therapy (SABR).
Materials and methods
We retrospectively compared the Planning Target Volumes (PTVs), the spared healthy liver parenchyma volumes, the Treatment Planning System (TPS) and machine performances, and the patients' outcomes when using either a conventional accelerator (Versa HD®, Elekta, Utrecht, NL) with Cone Beam CT as the IGRT tool or an MR-Linac system (MRIdian®, ViewRay, CA).
Results
From November 2014 to February 2020, 59 patients received a SABR treatment (41 and 18 patients in the Linac and MR-Linac group, respectively) for 64 primary or secondary liver tumors. The mean tumor size was superior in the MR-Linac group (37,91cc vs. 20.86cc). PTV margins led to a median 74%- and 60% increase in target volume in Linac-based and MRI-Linac-based treatments, respectively. Liver tumor boundaries were visible in 0% and 72% of the cases when using CBCT and MRI as IGRT tools, respectively. The mean prescribed dose was similar in the two patient groups. Local tumor control was 76.6%, whereas 23.4% of patients experienced local progression (24.4% and 21.1% of patients treated on the conventional Linac and the MRIdian system, respectively). SABR was well-tolerated in both groups, and the use of MR-guided radiation therapy prevented ulcerous disease occurrence.
Conclusion
The use of MRI as IGRT allows for the reduction of the amount of healthy liver parenchyma irradiated without any decrease of the tumor control rate, which would be helpful for dose escalation or subsequent liver tumor irradiation if needed. On-line adaptive treatments seem to reduce gastrointestinal toxicity.
The issues of endometriosis hormonal treatment in reproductive age women
Authors: Ivanov I. A. 
Published: December 2022

Endometriosis is one of the most common gynecological diseases associated with severe pelvic pain, uterine bleeding, and infertility. Current treatment patterns include endometriosis excision and medical management. Since endometriosis is a chronic disease with a recurrent clinical course, the crucial role holds a long-term suppressive therapy. It should be characterized by high efficacy, tolerability, a favorable safety profile, as well providing sustained remission and improving the quality of life. The current review summarizes the modern data on conservative management, mechanisms of hormonal therapeutic effects. The national recommendations of Russian and international obstetrics and gynecology societies were analyzed, taking into account the results of systematic reviews, meta-analyses and randomized clinical trials. Combined oral contraceptives and progestogens are considered as first-line hormone therapy. Choosing the proper medication is a controversial issue that requires a comprehensive understanding of its effect on various forms of endometriosis. The review analyzes comparative data on the effectiveness, safety, side effects, impact on the quality of life, the frequency of relapse during various progestogens monotherapy and oral contraceptives, including different dosage regimens. This data allows making an optimal choice of long-term management, with high compliance and efficiency, associated with low recurrence rate.
Overview of residual disinfection practice by European water suppliers
Authors: Breach R. A. 
Published: December 2022

Abstract
This paper summarises the current approach to disinfection in different European countries, and describes some of the factors that will drive change. Historically, the wide diversity in water resource availability and supply infrastructure across the Continent, as well as disinfection philosophy, have all influenced disinfection practice. However, in the future new EU regulatory standards for disinfection by¬products and customer pressure for improved water taste, will also have a growing impact. The paper reviews the fundamental principles of disinfection, both at source and in the distribution network, and highlights the critical issue of balancing microbial risk against achievement of low disinfection by-product levels and acceptable tastes for customers, New technology is facilitating moves towards low or even zero disinfectant residuals, However, whilst the goal of zero network residuals and high standards of microbiological safety has already been achieved in some parts of Europe, in many supply systems this will only be possible at significant cost.
Comparison of guideline- and model-based WWTP design for uncertain influent conditions
Authors: Lindblom Erik U. , Samuelsson Oscar 
Published: December 2022

Abstract
In this study, two methods for wastewater treatment plant (WWTP) dimensioning were compared: (1) a traditional guideline-based approach, and (2) a mechanistic model-based approach. The design outputs depended on uncertainties in correlated influent concentrations, which emphasises the importance of uncertainty analysis. The results showed that model-based design could simplify and reduce the time required for uncertainty and sensitivity analysis compared to a conventional design approach, in which the equations are solved manually and iteratively. A benefit of the conventional design approach was the simple interpretation of which factors limited the design capacity. In the end, this study shows the potential, as well as the need for, model-based design of WWTPs.
Adsorptive removal of pharmaceutically active compounds from multicomponent system using Azadirachta indica induced zinc oxide nanoparticles: analysis of competitive and cooperative adsorption
Authors: Sanjeev Nayanathara O. , Vallabha Manjunath Singanodi , Valsan Aswathy E 
Published: December 2022

Abstract
In this research, zinc oxide (ZnO) nanoparticles synthesized using neem leaf (Azadirachta indica) extract were used as an adsorbent for removing two widely used pharmaceutical compounds acetaminophen (AMP) and sulfadiazine (SDZ). The synthesized ZnO nanoparticles were characterized using SEM-EDS, FTIR, TEM, BET, and XRD analysis. The synthesized ZnO nanoparticles were found to be in the size range of 10 nm with a surface area of 48.551 m2/g. The adsorptive performance of ZnO nanoparticles in both mono-component (MoS) and multi-component system (MuS) was investigated under various operational parameters viz. contact time, temperature, pH, concentration of pharmaceutical compound and ZnO nanoparticles dose. It was observed that the maximum adsorption capacity of ZnO nanoparticles was 7.87 mg/g and 7.77 mg/g for AMP and SDZ, respectively, under the optimum conditions of 7 pH and 2 g/L adsorbent dosage. The experimental data best-fitted with the pseudo-second-order model and Langmuir model, indicating monolayer chemisorption. Further investigation on removal of AMP and SDZ from multicomponent system was modelled using a Langmuir competitive model. The desorption study has shown 25.28% and 22.4% removal of AMP and SDZ from the surface of ZnO nanoparticles. In general, green synthesized ZnO nanoparticles can be utilized effectively as adsorbent for removal of pharmaceutically active compounds from wastewater.
CORPO EM MUTAÇÃO E PERFORMATIVIDADE DURANTE PANDEMIA COVID-19
Authors: Hermogenes Almada Franco 
Published: December 2022

Corpos pandêmicos que sofrem os efeitos causados ??por Covid-19 afetam a psique e a performatividade. Este artigo chama a atenção dos leitores para reflexões sobre os efeitos da pandemia em seus corpos e performatividades em um amplo espectro. A partir de um diagnóstico médico, busca compreender a origem da doença por meio da arte e da performance, encontrando as questões políticas e sociais como paradoxos a serem enfrentados. Isolamento e imanência encontram-se em um mesmo ambiente, isolamento, restrito, enquanto a comunicação se amplia de forma virtual, intacta, próspera e edificante.
Qual é o impacto do isolamento na arte do corpo vivo em uma relação política sadomasoquista?
An Overview of the Role of Membrane Proteins in Microbial Solvents
Tolerance
Authors: Peng Ren , Ai Lei , Mei Fangwei 
Published: December 2022

Background:
Solvent tolerance is a desired feature of microorganisms for their application
in biotechnology. Organic solvent-tolerant microorganisms are able to thrive in the presence of
organic solvents. Several mechanisms have been proposed to elucidate their intrinsic tolerance to
organic solvents.

Objective:
Membrane proteins related to transporter, signal transduction, and material and energy
metabolism are involved in solvent tolerance. Optimization of the expression level of membrane
proteins and engineering of membrane proteins are utilized to tackle the toxicity caused by organic
solvents.

Results:
Membrane proteins related to transporter, signal transduction, and material and energy
metabolism are involved in solvent tolerance. Optimization of the expression level of membrane
proteins and engineering of membrane proteins are utilized to tackle the toxicity caused by organic
solvents.

Conclusions:
Membrane proteins occupy a strikingly important position in microbial solvent
tolerance. Further research on novel methods in membrane proteins, trade-offs among overexpression
and toxicity of membrane proteins and solvent yield, and a direct relationship between signaling
pathways and solvent tolerance will advance the utilization of organic solvent-tolerant
microorganisms in biotechnology.
Mir-21-5p and Mir-455-5p as Markers for Diagnosis and Prognosis of
Rectal Adenocarcinoma may Reduce Local CD4+ and CD8+ Lymphocyte
Infiltration
Authors: Deng Heng , Shi Haiping , Yuan Xiancang , Zhang Jun 
Published: December 2022

Objective:
This study aimed to verify miRNAs and the molecular mechanisms of diagnostic
and prognostic biomarkers for rectal adenocarcinoma.

Methods:
Two miRNA datasets of rectal adenocarcinoma were obtained from GEO and TCGA.
GEO2R tool, Venn diagram, Kaplan-Meier survival analysis, KEGG pathway analyses, DIANA
TOOLS, and Wilcoxon rank-sum test were used for biological information analysis. The diagnostic
utility of miRNAs and immune infiltration of tumors in Chinese patients were validated by RTqPCR
and immunofluorescence analysis.

Results:
MiR-21-5P and miR-455-5p were both found to have a significant correlation with poor
prognosis and higher expression in rectal adenocarcinoma. Besides, the ability to prognosis was
independent of the clinicopathological stage. MiR-21-5P and miR-455-5p were enriched in the
TGF-beta, Wnt, MAKP, and PI3K-AKT signaling pathways. Meanwhile, the high expression phenotype
of miR-21-5P and miR-455-5p decreased CD4+ and CD8+ T cells.

Conclusion:
In summary, we found two significant diagnostic and prognostic miRNAs of rectal
adenocarcinoma via integrated bioinformatics approach and clinical trials, which might decrease
CD4+ and CD8+ T cells.
KRAS Pathway-based Therapeutic Approaches in Pancreatic Cancer
Authors: Althaiban Abdullah , Thyagarajan Anita , Prakash Sahu Ravi 
Published: December 2022

Abstract:
Pancreatic ductal adenocarcinoma (PDAC) is one of the highly aggressive malignancies and the leading cause of cancer-related deaths. Despite recent advancements, the overall therapeutic responses in PDAC patients remained relatively low or short-lived. While KRAS is the most frequently mutated proto-oncogene and represents a critical driver, it remains challenging to target all mutant variants. Thus, strategies to target the downstream signaling cascades (RAS-RAF-MEK-ERK) in PDAC were associated with improved response rates. Nevertheless, the activation of other oncogenic cascades, such as PI3K/AKT/mTOR, has also been documented within the same context and implicated in the development of acquired tumor resistance mechanisms and/or reduced efficacy of therapeutic agents. Therefore, an in-depth understanding of overlapping and intersecting pathways is required to overcome the tumor resistance mechanisms to devise novel approaches to enhance the effectiveness of ongoing treatment options. The current review highlights the mechanistic insights from cellular and preclinical studies with particular emphasis on KRAS (i.e., MEK and ERK)-based approaches for PDAC treatment.