bluuebunny/crossref_metadata_2025_split huggingface dataset:
The safe and effective use of supercritical CO2-processed bone allografts for cervical and lumbar interbody fusion: A retrospective study
Authors: Aurouer Nicolas , Guerin Patrick , Cogniet Arnaud , Pedram Morad 
Published: February 2023

IntroductionThe clinical efficacy and safety of supercritical CO2-processed bone allografts prepared from living donors has yet to be confirmed in spinal surgery. Here we report our clinical and surgical experience of using supercritical CO2-processed bone allografts for lumbar and cervical fusion.MethodsSixteen patients underwent one or two level anterior cervical discectomy and fusion and 37 patients underwent anterior retroperitoneal route lumbar fusion using bone allografts processed using supercritical CO2 extraction combined with chemical viral inactivation. Fusion success was assessed radiographically in the immediate postoperative period and at one month, six months, one year, and three years postoperatively. Function and pain were assessed using visual analog scales, Odom's criteria, the neck disability index (NDI), and the Oswestry disability index (ODI).ResultsAt a mean of 43 and 47 months postoperatively, 95.3% and 90.5% of cervical and lumbar fusion patients had radiographic evidence of bone fusion, respectively. Over 80% of patients reported good to excellent outcomes according to Odom's criteria, the perception of pain significantly decreased, and the mean NDI and ODI scores significantly improved at the last follow-up compared with before the operations. There were no safety concerns. For the cervical group, the mean NDI score improved from 26.3 ± 6.01 preoperatively to 15.00 ± 8.03 and 17.60 ± 13.95 at immediate post-op (p = 0.02) and last follow-up visits (p = 0.037) respectively. For the lumbar cases, the mean ODI score improved from 28.31 ± 6.48 preoperatively to 14.68 ± 5.49 (p &lt; 0.0001) and 12.54 ± 10.21 (p &lt; 00001) at immediate post-op and last follow-up visits respectively.ConclusionWithin the limitations of this study, the use of supercritical CO2-processed bone allografts resulted in satisfactory clinical outcomes and fusion rates with acceptable safety for both cervical and lumbar surgeries.
A qualitative study exploring the perceived effects of veterinarians' mental health on provision of care
Authors: Campbell Megan , Hagen Briana N. M. , Gohar Basem , Wichtel Jeffrey , Jones-Bitton Andria 
Published: February 2023

IntroductionVeterinary medicine is a rewarding, yet demanding profession with a myriad of occupational stressors that can impact the mental health of veterinarians. Stress, mental health outcomes, and associated risk factors amongst veterinarians have been well-researched. Much less research has investigated how high stress and/or poor mental health can impact veterinarians' provision of care.MethodsOne-on-one research interviews were conducted with 25 veterinarians at a Canadian veterinary conference in July 2016 and verbatim transcripts were produced from the audio recordings. The research team collaboratively analyzed the interviews using thematic analysis.ResultsFive themes described the perceived impacts of high stress and/or poor mental health: perceived negative impacts on interactions with (1) co-workers and (2) clients; (3) reduced concentration; (4) difficulty in decision making; and (5) reduced quality of care.DiscussionThese results highlight the perceived impacts of self-reported high stress and/or poor mental health on veterinary team dynamics, the potential to impact case outcomes, and possibly endanger patient safety. Interventions to help mitigate the impacts of high stress and poor mental health are discussed.
SARS-CoV-2 Vaccination-Induced Immunogenicity in Heart Transplant Recipients
Authors: Memenga Felix , Kueppers Simon Thomas , Borof Katrin , Kirchhof Paulus , Duengelhoef Paul Maria , Barten Markus Johannes , Lütgehetmann Marc , Berisha Filip , Fluschnik Nina , Becher Peter Moritz , Kondziella Christoph , Bernhardt Alexander M. , Reichenspurner Hermann , Blankenberg Stefan , Magnussen Christina , Rybczynski Meike 
Published: February 2023

Among heart transplant (HT) recipients, a reduced immunological response to SARS-CoV-2 vaccination has been reported. We aimed to assess the humoral and T-cell response to SARS-CoV-2 vaccination in HT recipients to understand determinants of immunogenicity. HT recipients were prospectively enrolled from January 2021 until March 2022. Anti-SARS-CoV-2-Spike IgG levels were quantified after two and three doses of a SARS-CoV-2 vaccine (BNT162b2, mRNA1273, or AZD1222). Spike-specific T-cell responses were assessed using flow cytometry. Ninety-one patients were included in the study (69% male, median age 55 years, median time from HT to first vaccination 6.1 years). Seroconversion rates were 34% after two and 63% after three doses. Older patient age (p = 0.003) and shorter time since HT (p = 0.001) were associated with lower antibody concentrations after three vaccinations. There were no associations between vaccine types or immunosuppressive regimens and humoral response, except for prednisolone, which was predictive of a reduced response after two (p = 0.001), but not after three doses (p = 0.434). A T-cell response was observed in 50% after two and in 74% after three doses. Despite three vaccine doses, a large proportion of HT recipients exhibits a reduced immune response. Additional strategies are desirable to improve vaccine immunogenicity in this vulnerable group of patients.
Effects of Berries, Phytochemicals, and Probiotics on Atherosclerosis through Gut Microbiota Modification: A Meta-Analysis of Animal Studies
Authors: Khalili Leila , Centner Ann Marie , Salazar Gloria 
Published: February 2023

Atherosclerosis is a major cause of death and disability. The beneficial effects of phytochemicals and probiotics on atherosclerosis have gained significant interest since these functional foods can improve inflammation, oxidative stress, and microbiome dysbiosis. The direct effect of the microbiome in atherosclerosis, however, needs further elucidation. The objective of this work was to investigate the effects of polyphenols, alkaloids, and probiotics on atherosclerosis using a meta-analysis of studies with mouse models of atherosclerosis. Identification of eligible studies was conducted through searches on PubMed, Embase, Web of Science, and Science Direct until November 2022. The results showed that phytochemicals reduced atherosclerosis, which was significant in male mice, but not in females. Probiotics, on the other hand, showed significant reductions in plaque in both sexes. Berries and phytochemicals modulated gut microbial composition by reducing the Firmicutes/Bacteroidetes (F/B) ratio and by upregulating health-promoting bacteria, including Akkermansia muciniphila. This analysis suggests that phytochemicals and probiotics can reduce atherosclerosis in animal models, with a potentially greater effect on male animals. Thus, consumption of functional foods rich in phytochemicals as well as probiotics are viable interventions to improve gut health and reduce plaque burden in patients suffering from cardiovascular disease (CVD).
Prolonged Inflammation and Infectious Changes in the Corneal Epithelium Are Associated with Persistent Epithelial Defect (PED)
Authors: Dutta Tanmoy , Sangwan Jyoti , Mondal Moumita , Vohra Mehak , Nidhi Vatsala , Gour Abha , Kapur Neha , Gupta Nidhi , Bhowmick Tuhin , Chandru Arun , Mathur Umang , Sangwan Virender Singh , Acharya Manisha , Tiwari Anil 
Published: February 2023

Purpose: Failure of rapid re-epithelialization within 10–14 days after corneal injury, even with standard supportive treatment, is referred to as persistent corneal epithelial (CE) defect (PED). Though an array of genes regulates reepithelization, their mechanisms are poorly understood. We sought to understand the network of genes driving the re-epithelialization in PED. Method: After obtaining informed consent, patients underwent an ophthalmic examination. Epithelial scrapes and tears samples of six PED patients and six individuals (control) undergoing photorefractive keratectomy (PRK) were collected. RNA isolation and quantification were performed using either the epithelial scrape taken from PED patients or from HCLE cells treated with control tears or tears of PED patients. Quantitative real-time polymerase chain reaction (qRT-PCR) was performed to detect the expression of a few important genes in CE homeostasis, inflammation, and cell–cell communication, viz., Kruppel-like factor 4 (KLF4), GPX4, IL6, TNFα, STING, IL8, desmoglein, and E-cadherin, among others. Their expressions were normalized with their respective housekeeping genes and fold changes were recorded. KLF4 localization and MMPs activity was carried out via immunofluorescence and zymography, respectively. Results: KLF4, a transcription factor important for CE homeostasis, was upregulated in tears-treated HCLE cells and downregulated in PED patients compared to the healthy PRK group. Cell–cell communication genes were also upregulated in tears-treated cells, whereas they were downregulated in the PED tissue group. Genes involved in proinflammation (IL6, 282-fold; TNFα, 43-fold; IL8, 4.2-fold) were highly upregulated in both conditions. MMP9 activity increased upon tears treatment. Conclusions: This study suggests that tears create an acute proinflammatory milieu driving the PED disease pathology, whereas the PED patients scrapes are an indicator of the chronic stage of the disease. Interferons, pro-inflammatory genes, and their pathways are involved in PED, which can be a potential target for inducing epithelialization of the cornea.
PREDIKSI SISWA-SISWI SMK AZ-ZAHRA MLONGGO MASUK PASAR KERJA MENGGUNAKAN ALGORITMA NAIVE BAYES
Authors: Zyen Akhmad Khanif , Widiastuti Nur Aeni 
Published: February 2023

Siswa-siswi SMK Azzahra setiap tahunnya sebagian besar diharapkan langsung bekerja sesuai bidangnya, tapi dalam pengolahan tingkat nilai prestasi siswa yang menetukan kriteria masuk pasar kerja masih menggunakan cara manual yang terdapat banyak kelemahan dan berpotensi mengakibatkan kesalahan. Perlu adanya Algoritma Klasifikasi untuk memecahkan permasalahan ini, ada salah satu Algoritma Klasifikasi yang sudah terbukti akurasi dan kecepatan yang baik untuk memecahkan permasalahan tersebut yaitu Algoritma Naive Bayes. Oleh karena itu penulis menganalisis prediksi siswa-siswi masuk pasar kerja dengan metode Naïve Bayes untuk menentukan lulus tidaknya masuk kriteria pasar kerja. Penulis membuat perhitungan metode Naïve Bayes secara manual menggunakan Excel dan menggunakan aplikasi pendukung Rapidminer 5.3, dimana dalam penelitian ini data yang digunakan tahun 2018-2020 denga total 247, dataset tersebut dibagi menadi 2 bagian, yakni 152 data training dan 75 data testing, dimana memprediksi siswa yang lulus kriteria masuk pasar kerja sebanyak 57 orang dan yang tidak lulus kriteria masuk pasar kerja sebanyak 18 orang. Hal ini bereda dengan data testing siswa dimana yang lulus kriteria masuk pasar kerja sebanyak 46 orang dan yang tidak lulus kriteria masuk pasar kerja sebanyak 29 orang dan akurasi yang diperoleh mendapatkan nilai sebesar 77,33%. Jadi, dapat disimpulkan bahwa pengujian menggunakan metode Naïve Bayes dapat mendukung untuk memprediksi lulus tidaknya siswa-siswi dalam masuk pasar kerja.
Kemampuan Gerak Dasar Atletik Lari Jarak Pendek pada Siswa Kelas VIII B SMP PGRI 7 Denpasar
Authors: Putra Dalem Anak Agung Gde Bagus Maheswara , Putra Laksana Anak Agung Ngurah , Adnyana I Wayan 
Published: February 2023

ABSTRAK
Penelitian ini bertujuan untuk mengetahui kemampuan gerak dasar atletik lari jarak pendek pada siswa kelas VIII B SMP PGRI 7 Denpasar. Jenis penelitian ini adalah kualitatif deskriptif. Adapun informan dalam penelitian ini adalah 6 informan yang terdiri dari 5 siswa kelas VIII B dan 1 informan guru penjaskes kelas VIII B SMP PGRI 7 Denpasar. Jenis data kualitatif dengan kata-kata tertulis dan sumber data yang digunakan dalam penelitian ini adalah sumber data primer dan sekunder. Sumber data primer yang digunakan dalam penelitian ini pengamatan dan perhitungan langsung, data skunder yang digunakan yaitu data wawancara dan kuesioner. Teknik pengumpulan data menggunakan triangulasi yaitu observasi, wawancara, dan kuesioner. Adapun analisis data yang digunakan yaitu analisis Miles dan Huberman yaitu analisis data model interaktif yang melalui langkah-langkah pengumpulan data, reduksi data, penyajian data, dan penarikan kesimpulan. Hasil penelitian ini menunjukkan bahwa belum maksimalnya kemampuan siswa dalam gerak dasar atletik lari jarak pendek yaitu kategori cukup. Dengan persentase hasil nilai observasi sebanyak 16 siswa (50%) berada di kategori baik dan sebanyak 16 siswa (50%) berada dalam kategori cukup. Hasil data wawancara menunjukkan belum maksimalnya proses pembelajaran karena factor penghambat. Hasil data kuesioner menunjukkan sebanyak 12 siswa (37,5%) dalam kategori baik dan sebanyak 20 siswa (62,5%) berada dalam kategori cukup.dari ketiga data tersebut mendapatkan hasil data yang belum maksimal dengan kategori cukup dalam kemampuan gerak dasar atletik lari jarak pendek pada siswa kelas VIII B SMP PGRI 7 Denpasar.
Kata kunci :Kemampuan Gerak Dasar, Atletik, Lari Jarak Pendek.
FAKTOR-FAKTOR YANG MEMPENGARUHI KEPATUHAN WAJIB PAJAK BADAN SUATU STUDI DI KPP PRATAMA TAMPAN PEKANBARU
Authors: Liviawati Liviawati , Syofyan Azhari 
Published: February 2023

Pajak merupakan sumber penerimaan utama negara yang digunakan untuk membiayai pengeluaran pemerintah dan pembangunan,yang setiap tahunnya akan semakin meningkat. Oleh sebab itu pemerintah berusaha meningkatkan penerimaan negara dari sektor pajak. Berdasarkan sensus penduduk tahun 2021, jumlah penduduk Indonesia mencapai 68 juta rumah tangga akan tetapi yang memiliki NPWP hanya 19,9 juta saja. Begitu juga dengan wajib pajak badan, jumlah badan yang memiliki NPWP hanya 54% dari jumlah yang seharusnya ( jumlah badan usaha yang ada di Indonesia 1,6 juta, yang memiliki NPWP 872.995 perusahaan). Melihat data diatas dapat kita katakan bahwa kepatuhan wajib pajak di Indonesia masih rendah, dan ini diperlukan kerja keras dan langkah cerdas agar potensi penerimaan pajak ini dapat ditingkatkan oleh pemerintah. Oleh Sebab itu penelitian ini melakukan analisa mengenai faktor apa yang mempengaruhi kepatuhan wajib pajak. Adapun faktor yang diteliti pada penelitian ini adalah kesadaran wajib pajak, sangsi pajak, transparansi dan medernisasi. Hasil dari penganalisaan terhadap faktor yang mempengaruhi kepatuhan wajib pajak secara parsial, kesadaran wajib pajak, sangsi pajak, transparansi dan modernisasi berpengaruh secara signifikan terhadap kepatuhan wajib pajak.Hal ini perlu diketahui oleh pemerintah agar pemerintah dapat merancang strategi yang tepat untuk meningkatkan penerimaan dari pajak. Studi ini dilakukan pada Kantor Pelayanan Pajak Pratama Tampan kota Pekanbaru.
Du rôle de la nature dans le design moderniste
Authors: Elalouf Jérémie 
Published: February 2023

Bruno Latour a avancé qu’il était possible de comprendre les arts et les sciences « modernes » comme relevant d’un même type de rapport au monde, le naturalisme. Nous proposons de discuter cette thèse en nous intéressant plus spécifiquement à l’histoire du design, à travers une analyse de textes de László Moholy-Nagy. Notre argument est que le design moderne a proposé une critique du naturalisme, bien que cette critique ne soit pas dénuée d’ambivalence et d’ambiguïtés.
Turnitin no determina plagio
Authors: Ybaseta-Medina Jorge 
Published: February 2023

La integridad científica es la principal preocupación de la comunidad investigadora mundial (1). Ante la posibilidad de prácticas o actitudes antiéticas en el proceso de la elaboración de la tesis, las universidades están en la necesidad de usar un software que se encargue de comparar las similitudes del texto presentado con obras que se encuentren publicadas en otros portales que están registrados en su servidor, si encuentra similitudes las muestra indicando también la fuente original (2).
El software Turnitin proporciona un "índice de similitud”, lo cual no significa plagio, ya que el plagio se comete cuando no se cita la fuente original de donde se copió o interpretó un contenido de la obra evaluada, y el turnitin no indica si existe o no dentro del texto un llamado o cita hacia una referencia bibliográfica que está dentro del texto de la obra o en la sección referencias bibliográficas, esta herramienta podría tener una contribución mayor si el informe resultante de la evaluación con el Turnitin es usado tanto por docentes como por alumnos para revisar, corregir y/o agregar las fuentes de información consultadas durante el desarrollo de una investigación científica y la preparación del manuscrito final, lo que ayudaría a garantizar calidad académica y científica de las obras publicadas ya sea como informes de investigación, tesis o artículos científicos (1,2).
Parameters for ferroelectric phase stabilization of sputtered undoped hafnium oxide thin films
Authors: Berg Fenja , Lübben Jan , Böttger Ulrich 
Published: February 2023

Abstract
In this work, various stabilization factors for the ferroelectric phase of undoped hafnium oxide prepared by physical vapour deposition were investigated. The capping of the thin films with platinum top electrodes before annealing, as well as the amount of oxygen during sputter deposition and subsequent annealing was shown to have a significant influence on the resulting ferroelectric properties and phase of the HfO
x
layer. When the prepared films were not capped, only one specific set of process parameters was found to lead to the formation of the ferroelectric phase. We conclude that capping is a crucial condition for stabilizing the ferroelectric phase. Furthermore, it is shown that the amount of oxygen supply during all fabrication processes determines the resulting ferroelectric phase fraction for capped samples. Increasing the oxygen flow during sputtering and annealing results in a larger monoclinic phase fraction and thus a decrease of the remanent polarization.
Atomistic simulations of thermal conductivity in novel GeC channel materials from first-principles molecular dynamics calculations
Authors: Lee Shao-Chen , Chen Yu-Ting , Liu Cheng-Rui , Wang Sheng-Min , Tang Ying-Tsan 
Published: February 2023

Abstract
Silicon carbide (SiC) has emerged as a candidate material for next-generation power devices to replace traditional silicon power devices. They feature smaller size, faster switching speed, simpler cooling, and greater reliability than Si-MOSFETs. To date, however, the thermal conductance of GeC-based power MOSFETs is unclear. This work explains the heat transfer of GeC by simulating the thermal conductivity through molecular dynamics (MD) and proposes a potential 4H-GeC power MOSFET with wide bandgap and high thermal conductivity to replace Si-MOSFETs.
Compact aerial ultrasonic source integrating the transverse vibration part with the bolt-clamped Langevin transducer
Authors: Ohfuchi Ryota , Kasashima Takashi , Itoh Shinsuke , Asami Takuya , Miura Hikaru 
Published: February 2023

Abstract
We have previously developed a compact circular vibrating plate aerial ultrasonic source with a grooved uniform rod that can produce a large vibration displacement by using piston vibration and emit intense sound waves perpendicular to the vibration surface. In this paper, to create a compact ultrasonic source that can radiate intense aerial ultrasonic waves, we produced a compact aerial ultrasonic source integrating the transverse vibration part with a bolt-clamped Langevin transducer and we investigated the sound source characteristics. These results demonstrated that compared with a conventional source, the length of our source was shorter, the sound pressure was higher, and its structure was simpler.
Characterization of magnesium channeled implantation layers in GaN(0001)
Authors: Suyama Atsushi , Kawanowa Hitoshi , Minagawa Hideaki , Maekawa Junko , Nagamachi Shinji , Aoki Masahiko , Ohta Akio , Makihara Katsunori , Miyazaki Seiichi 
Published: February 2023

Abstract
The effect of Mg channeled implantation into epitaxially grown gallium nitride (GaN) was studied using Hall-effect measurements, photoluminescence (PL), transmission electron microscopy (TEM), scanning transmission electron microscopy (STEM) and Rutherford backscattering spectroscopy (RBS). In the channeled implantation, deeper profiles were obtained with lower implantation energy and less damage compared to random implantation. The donor–acceptor pair signal at ∼3.28 eV, suggesting that Mg is activated, was confirmed by PL measurement when the ion dose and implantation energy are 1 × 1014 cm−2 and 20 keV, respectively. However, even with channeled implantation, several types of defects including point defects and oblong defects as seen in the random implantation were observed by TEM/STEM analysis. RBS analysis showed slightly worse crystal qualities in channeled implantation compared to non-implanted samples. Mg channeled implantation is useful to achieve deeper profiles (>1 μm), but further condition tuning of process will be necessary for practical application.
Enhanced tunneling current and low contact resistivity at Mg contacts on heavily phosphorus-ion-implanted SiC
Authors: Hara Masahiro , Kaneko Mitsuaki , Kimoto Tsunenobu 
Published: February 2023

Abstract
Mg contacts are formed on P+-implanted SiC (1 × 1017–8 × 1019 cm−3) and their current–voltage characteristics and contact resistivity (ρ
c) are analyzed. The current density through the contacts on the ion-implanted SiC is several orders of magnitude larger than that on SiC epitaxial layers with the same doping density. For the Mg contacts formed on ion-implanted SiC with 8 × 1019 cm−3, a very low ρ
c of 2 × 10−6 Ωcm2, which is comparable to that of typical Ni-based contacts sintered at high temperature, is achieved without any thermal treatment after electrode deposition.
IDENTIFIKASI MIKOSIS PARU PADA PASIEN TUBERKULOSIS DENGAN BTA POSITIF DI KOTA JAMBI
Authors: Syarthibi Ahmad , Mustopa Rd , Anggraini Anggraini 
Published: February 2023

Latarbelakang: Pasien TB BTA Postif membutuhkan waktu lama makan obat. Antibiotik memiliki efek secara terapeutik yaitu menyerang organisme infeksius juga mengeliminasi bakteri lain yang bukan penyebab penyakit, menyebabkan perubahan ekosistem flora normal sehingga terjadi gangguan alami ekologi mikrobial, ketidak seimbangan flora normal dapat mengakibatkan kolonisasi jamur saluran napas dan akan menginvasi mukosa serta berkembang biak. Penelitian ini bertujuan untuk menganalisis kejadian infeksi jamur pada pasien TB BTA positif, meliputi kejadian infeksi jamur pada pasien, mengetahui jenis jamur yang menginfeksi pasien serta mengetahui infeksi jamur berdasarkan lama mengkonsusi OAT pada pasien TB BTA positif.
Metode: Desain Penelitian deskriptif cross sectional bertempat di puskesmas Rujukan Mikroskopis kota Jambi. Pemeriksaan TB dilakukan di puskesmas sedangkan pemeriksaan jamur dilakukan di laboratorium Mikologi Poltekkes Kemenkes Jambi Jurusan TLM. total sampling dilakukan pada periode pengambilan data Juli - Agustus 2021.
Hasil: Pemeriksaan kultur didapatkan hasil 47,6% ditemukan infeksi jamur pada sputum, lebih banyak ditemukan pada pasien laki-laki (53,8%) dan pasien TB paru dengan lama pengobatan lebih dari 2 bulan/fase lanjut (50%), ditemukan Candida Sp sebagai penyebab terbanyak mikosis pada sputum (60%), Aspergilus Sp (30%) dan ditemukan adanya koloni jamur berbeda (10%) penyebab mikosis.
Kesimpulan: Mikosis ditemukan pada sputum pasien TB Paru dengan pengobatan lebih dari 2 bulan serta Sebagian besar diakibatkan infeksi Candida Sp.