bluuebunny/crossref_metadata_2025_split huggingface dataset:
Arrhythmogenic Cardiomyopathy: from Preclinical Models to Genotype–phenotype Correlation and Pathophysiology
Authors: Fan Xuehui , Yang Guoqiang , Duru Firat , Grilli Maurizio , Akin Ibrahim , Zhou Xiaobo , Saguner Ardan Muammer , EI-Battrawy Ibrahim 
Published: September 2023

AbstractArrhythmogenic cardiomyopathy (ACM) is a hereditary myocardial disease characterized by the replacement of the ventricular myocardium with fibrous fatty deposits. ACM is usually inherited in an autosomal dominant pattern with variable penetrance and expressivity, which is mainly related to ventricular tachyarrhythmia and sudden cardiac death (SCD). Importantly, significant progress has been made in determining the genetic background of ACM due to the development of new techniques for genetic analysis. The exact molecular pathomechanism of ACM, however, is not completely clear and the genotype–phenotype correlations have not been fully elucidated, which are useful to predict the prognosis and treatment of ACM patients. Different gene-targeted and transgenic animal models, human-induced pluripotent stem cell-derived cardiomyocyte (hiPSC-CM) models, and heterologous expression systems have been developed. Here, this review aims to summarize preclinical ACM models and platforms promoting our understanding of the pathogenesis of ACM and assess their value in elucidating the ACM genotype–phenotype relationship.
Graphical Abstract
Isolation and application of the novel Aspergillus nidulans (OD1) for nanocellulose production from some agro-cellulosic wastes
Authors: Darwesh Osama M. , Habib Youstina M. , Gharieb Mohamed M. , Matter Ibrahim A. 
Published: September 2023

AbstractMicrobial nanotechnology is currently helping to address human needs in many areas of life. One of these fields is the production of cellulose nanomaterials, which are used in many medical, agricultural, environmental and industrial applications. In this study, the novel strain Aspergillus nidulans optical density 1 (OD1) was isolated as cellulolytic fungus that has the ability to convert cellulose into nanocellulose through partial degradation under optimized conditions. The optimization conditions include incubation of fungal pellets with the microcrystalline cellulose (MCC) for 4 h at pH 6 with addition of 1 mM of Zn and 2 mM of Mn ions. Furthermore, feedback inhibition for exocellulase and B-glucosidase activity was performed to the concentrated cellulases of A. nidulans in order to prevent the complete degradation of cellulose, hence increasing nanocellulose yield. The better results of enzyme feedback inhibition were obtained due to addition of 1% of cellobiose and 2% glucose for the enzyme/MCC mixture for 4 h. The concentrated A. nidulans cellulases were applied to produce nanocellulose from cotton fibers as well as rice straw as common agricultural cellulosic materials and wastes. According to Transmission electron microscope (TEM) and particle size distribution, the average particle sizes of nanocellulose were (9–20) nm and (2–17) nm for cotton fibers and rice straw wastes, respectively. The obtained results revealed that nanocellulose can be biosynthesized using fungal cellulases produced under optimized conditions using cellulosic materials available as agricultural wastes. Further investigation of the produced cellulose nanomaterials can be conducted to demonstrate its compatibility with various medical, environmental, and industrial applications.
Cobalt: corporate concentration 1975–2018
Authors: Ericsson Magnus , Löf Anton , Löf Olof , Müller Daniel B. 
Published: September 2023

AbstractThe world’s dependency on cobalt mines in Congo and cobalt refineries in China is seen as serious security issues with potentially dangerous implications for the energy transition. However, Chinese refineries have a similar supply security issue as most of its cobalt concentrates are imported. Most supply security studies take a country perspective on market concentration and supply risks. However, control of the mines and refineries lies with the producing companies, not the governments of the countries where they are located. This paper analyses the corporate structure of the cobalt industry at the mine and the refinery stages over a longer time period to establish changes in the level of corporate concentration and to put the situation in 2018 in perspective. The level of corporate concentration at the mine stage is low and does not raise concerns for market failures or a lack of competitiveness. Corporate concentration of refined cobalt depends on the Chinese government’s influence over Chinese production: if the state control over individual refineries is assumed to be strong, the corporate concentration is high. Mine stage supply security could be strengthened by improving the general political stability in the DRC to make the country more attractive for investors other than the present ones. Increased local beneficiation would strongly benefit Congo and reduce China’s influence. This is a long and complicated process and its success is not at all certain. At the refinery stage, the solution is much easier: reliability of supply could be improved by constructing refineries in countries outside China.
Sustainability and Environmental Impact of the Tourism Sector: Analysis Applied to Swimming Pools in the Hotel Industry on the Costa Brava
Authors: Arimany-Serrat Núria , Gomez-Guillen Juan-Jose 
Published: September 2023

Abstract
The aim of this research is to critically evaluate the environmental implications of public pools in Costa Brava hotels, with a focus on their impact in terms of energy, water, and carbon footprint. The methodology employed hinges on the characterization of the stock of pools installed in the hotels of the region. Following this characterization, calculations were undertaken regarding water and energy consumption, in addition to the computation of the equivalent carbon footprint for the entirety of the pools combined. The findings of the study reveal an annual energy consumption of 1,850.2 MWh/year and an annual water evaporation consumption of 50,105 m3/year. As a result, the carbon footprint corresponding to these consumptions is 481.8 tCO2 eq./year. Identified areas of improvement within the facilities encompassed the modernization of equipment towards more contemporary models with higher efficiencies, the adoption of holistic management approaches for pools, and the utilization of emerging modelling trends to enhance facility efficiency. Conclusions drawn from the research suggest that enhancing the sustainability of pools within the Costa Brava hospitality sector holds significant societal relevance, especially when considering the heightened water stress in Mediterranean climate zones during the peak tourist season. Improving the energy efficiency of these facilities not only contributes to environmental sustainability, but also cuts operational costs, allowing establishments to have more room to channel more resources towards their main hospitality tasks.

Highlights

Tourism is vital in global, Spanish, Catalan GDP and an environmental impact key.

Costa Brava hotel pools use 1,850 MWh/year, 50,105 m3 water/year, emit 482 tCO2/year.

Modern equipment, management, and modelling trends enhance pool sustainability.

Efficient pools cut costs, aid environment, free resources for hospitality.

Tourism's future relies on holistic sustainability; efforts and policies are vital.
Agreements Forbidden by Law vis-à-vis Agreements to Defeat the Law: How Are They Different?
Authors: Trakic Adnan 
Published: September 2023

AbstractThis article seeks to ascertain the difference between the agreements forbidden by law under section 24(a) and those intended to defeat the law under section 24(b) of the Malaysian Contracts Act 1950. Even though both subsections (a) and (b) cater to different types of illegality, the courts in Malaysia have often been applying them together without giving reasons why they do so. Their conjoined application prevails perhaps because there has been no convincing explanation of their differences, particularly when considered in the context of the common law doctrine of sham. This article attempts to fill that gap. The article suggests that 24(a) deals with the agreements that are expressly or impliedly forbidden by law, while 24(b) applies to sham contracts. This proposition is based on the analysis of the common law doctrine of sham and recent court decisions.
Hand hygiene knowledge and practices of family caregivers in inpatient pediatrics
Authors: Zahradnik Stephanie , Tsampalieros Anne , Okeny-Owere James , Webster Richard J. , Bedard Pat , Seidman Gillian , Thampi Nisha 
Published: September 2023

AbstractFamily caregivers are essential inpatient pediatric care partners, yet their handwashing knowledge and compliance are rarely studied. Through hand hygiene audits and self-administered questionnaires, we observed 9% compliance, significantly lower than self-reported practice. We suggest interventions to improve caregiver handwashing behaviors to decrease infection transmission risk to hospitalized children.
“Liberty of Conscience is Every Man’s Natural Right”: Historical Background of the First Amendment
Authors: BARTH JONATHAN 
Published: September 2023

AbstractLiberty of conscience, encompassing free speech, a free press, and freedom of religion, has a rich history in Anglo-American political thought, long predating the drafting of the First Amendment to the United States Constitution in 1789. The debate over licensing acts in seventeenth-century England; the advancement of principles of toleration by John Milton, Algernon Sidney, and John Locke in the same period; the renowned, impassioned, and highly influential essays of John Trenchard and Thomas Gordon in Cato’s Letters; the flourishing of a relatively free press and free church in eighteenth-century colonial America; and the liberty-championing assertions in the several declarations of rights in the newly independent states of America all played a critical role in shaping and inspiring the popular views in America that made the First Amendment possible.
Equivalence of Computer- and Paper-Based Administrations of the	SCHNAPP Spelling Test in German for Six-Year-Old Children
Authors: Schöfl Martin , Steinmair Gabriele , Zepnik Sabine , Gnambs Timo 
Published: September 2023

Abstract: The SCHNAPP Spelling Test is a novel screening instrument to identify at-risk children with poor spelling abilities in German at the beginning of primary school. Although originally developed as a computerized test to be administered on tablets, in school settings paper-pencil methods are often still preferred. Therefore, the present study on N = 390 children from first grades in Austrian primary schools examined the equivalence of computer and paper-pencil versions of the test. After demonstrating unidimensional measurement models in both assessment conditions, analyses of differential response functioning on the item and test level found no substantial testing mode effects. These results indicate that the SCHNAPP Spelling Test can be comparably used as a computer- or paper-based instrument in school assessments.
The Historical Development of Large‐Scale Paleoclimate Field Reconstructions Over the Common Era
Authors: Smerdon Jason E. , Cook Edward R. , Steiger Nathan J. 
Published: September 2023

AbstractClimate field reconstructions (CFRs) combine modern observational data with paleoclimatic proxies to estimate climate variables over spatiotemporal grids during time periods when widespread observations of climatic conditions do not exist. The Common Era (CE) has been a period over which many seasonally‐ and annually‐resolved CFRs have been produced on regional to global scales. CFRs over the CE were first produced in the 1970s using dendroclimatic records and linear regression‐based approaches. Since that time, many new CFRs have been produced using a wide range of proxy data sets and reconstruction techniques. We assess the early history of research on CFRs for the CE, which provides context for our review of advances in CFR research over the last two decades. We review efforts to derive gridded hydroclimatic CFRs over continental regions using networks of tree‐ring proxies. We subsequently explore work to produce hemispheric‐ and global‐scale CFRs of surface temperature using multi‐proxy data sets, before specifically reviewing recently‐developed data assimilation techniques and how they have been used to produce simultaneous reconstructions of multiple climatic fields globally. We then review efforts to develop standardized and digitized databases of proxy networks for use in CFR research, before concluding with some thoughts on important next steps for CFR development.
Origins of the Tsunami Following the 2023 Turkey–Syria Earthquake
Authors: Hu Gui , Satake Kenji , Li Linlin , Du Peng 
Published: September 2023

AbstractOn 6 February 2023, a local tsunami was recorded in the southeastern Mediterranean Sea following the Mw 7.7 Turkey–Syria inland strike‐slip earthquake. Due to the lack of underwater observation, the tsunami generation mechanism remains mysterious. To understand the source mechanisms, we analyzed the tsunami waveforms of four nearby tide gauges and located possible sources using a backward tsunami ray tracing approach. We then conducted forward numerical modelings for a range of possible source parameters. We show that there were probably two tsunami sources, inside and outside Iskenderun Bay, which may be related to thick coastal sediments. A source inside the Bay with a characteristic length of 7 km produced dominant periods of 10–30 min with negative initial motion, possibly generated by a landslide. Another source of 6 km length outside the Bay produced dominant periods of 2–10 min with positive initial motions, possibly related with liquefaction.
Surface‐Volume Scaling Controlled by Dissolution Regimes in a Multiphase Flow Environment
Authors: Zhou Chen‐Xing , Hu Ran , Deng Hang , Ling Bowen , Yang Zhibing , Chen Yi‐Feng 
Published: September 2023

AbstractFluid‐rock dissolution occurs ubiquitously in geological systems. Surface‐volume scaling is central to predicting overall dissolution rate R involved in modeling dissolution processes. Previous works focused on single‐phase environments but overlooked the multiphase‐flow effect. Here, through limestone‐based microfluidics experiments, we establish a fundamental link between dissolution regimes and scaling laws. In regime I (uniform), the scaling is consistent with classic law, and a satisfactory prediction of R can be obtained. However, the scaling for regime II (localized) deviates significantly from classic law. The underlying mechanism is that the reaction‐induced gas phase forms a layer, acting as a barrier that hinders contact between the acid and rock. Consequently, the error between measurement and prediction continuously amplifies as dissolution proceeds; the predictability is poor. We propose a theoretical model that describes the regime transition, exhibiting excellent agreement with experimental results. This work offers guidance on the usage of scaling law in multiphase flow environments.
Electron Rolling‐Pin Distributions Preceding Dipolarization Fronts
Authors: Xing X. N. , Liu C. M. , Cao J. B. 
Published: September 2023

AbstractElectron rolling‐pin distribution (RPDs), characterized by triple peaks at pitch angles 0°, 90°, and 180°, have recently been discovered in the terrestrial magnetosphere. Since the RPDs' formation is typically attributed to local betatron acceleration, RPDs have been believed to appear primarily inside strong magnetic regions, such as flux pileup regions (FPRs) behind dipolarization fronts (DFs). Different from such expectation, in this study we present unique observations of RPDs made by Cluster spacecraft in the terrestrial magnetotail, showing that RPDs are present inside weak magnetic field regions ahead of the DFs but absent in the strong magnetic field region behind them. The presence of RPD prior to the fronts may be atttributed to the combined effect of global betatron acceleration, global Fermi acceleration, and frontward transport driven by magnetic gradient drift. The atypical features of RPDs are important for fully understanding electron acceleration and transport in the magnetosphere.
A Physical Model for the Observed Inverse Energy Cascade in Typhoon Boundary Layers
Authors: Shao Xin , Zhang Ning , Tang Jie 
Published: September 2023

AbstractThe knowledge of the observed inverse energy cascade in typhoon boundary layers holds significant implications for understanding the formation, enhancement, and deformation of typhoons. This study reveals that the observed inverse energy cascade originates from the rapid rotation of typhoons. The transition from the direct energy cascade regime to the inverse energy cascade regime can be characterized by the Zeman length scale. The turbulence structures behave as two dimensional above the Zeman length scale. Through symmetry analysis, it is discovered that the ratio of the inverse energy cascade flux to the direct energy cascade flux is proportional to the turbulence Rossby number with a power of −2. These findings offer a framework for incorporating the inverse energy cascade into the turbulence parameterizations and improving typhoon modeling.
CaMKK2 as an emerging treatment target for bipolar disorder
Authors: Kaiser Jacqueline , Nay Kevin , Horne Christopher R. , McAloon Luke M. , Fuller Oliver K. , Muller Abbey G. , Whyte Douglas G. , Means Anthony R. , Walder Ken , Berk Michael , Hannan Anthony J. , Murphy James M. , Febbraio Mark A. , Gundlach Andrew L. , Scott John W. 
Published: September 2023

AbstractCurrent pharmacological treatments for bipolar disorder are inadequate and based on serendipitously discovered drugs often with limited efficacy, burdensome side-effects, and unclear mechanisms of action. Advances in drug development for the treatment of bipolar disorder remain incremental and have come largely from repurposing drugs used for other psychiatric conditions, a strategy that has failed to find truly revolutionary therapies, as it does not target the mood instability that characterises the condition. The lack of therapeutic innovation in the bipolar disorder field is largely due to a poor understanding of the underlying disease mechanisms and the consequent absence of validated drug targets. A compelling new treatment target is the Ca2+-calmodulin dependent protein kinase kinase-2 (CaMKK2) enzyme. CaMKK2 is highly enriched in brain neurons and regulates energy metabolism and neuronal processes that underpin higher order functions such as long-term memory, mood, and other affective functions. Loss-of-function polymorphisms and a rare missense mutation in humanCAMKK2are associated with bipolar disorder, and genetic deletion ofCamkk2in mice causes bipolar-like behaviours similar to those in patients. Furthermore, these behaviours are ameliorated by lithium, which increases CaMKK2 activity. In this review, we discuss multiple convergent lines of evidence that support targeting of CaMKK2 as a new treatment strategy for bipolar disorder.
5-Aminovaleric acid betaine predicts impaired glucose metabolism and diabetes
Authors: Haberbosch Linus , Kierszniowska Sylwia , Willmitzer Lothar , Mai Knut , Spranger Joachim , Maurer Lukas 
Published: September 2023

Abstract
Background
5-Aminovaleric acid betaine (5-AVAB) has recently been identified as a diet and microbial-dependent factor inducing obesity and hepatic steatosis in mice fed a Western diet. Accumulating evidence suggests a role in metabolic dysfunction associated with obesity, diabetes, and fatty liver disease. However, whether 5-AVAB plays a role in human disease is unclear, and human data are sparse.

Methods
We measured circulating 5-AVAB serum levels in 143 individuals with overweight or obesity participating in a randomized intervention study (NCT00850629) investigating the long-term effect of a weight maintenance strategy after diet-induced weight reduction.

Results
Higher 5-AVAB serum levels correlate with worse estimates of obesity, glucose metabolism, and hepatic steatosis after weight loss. Furthermore, higher 5-AVAB levels after weight loss independently predict detrimental changes in glucose metabolism 18 months after the successful weight reduction.

Conclusion
Our human data supports previous findings in rodents indicating a relevant, potentially disadvantageous function of 5-AVAB in the context of metabolic dysbalance.
Cdk12 maintains the integrity of adult axons by suppressing actin remodeling
Authors: Townsend L. N. , Clarke H. , Maddison D. , Jones K. M. , Amadio L. , Jefferson A. , Chughtai U. , Bis D. M. , Züchner S. , Allen N. D. , Van der Goes van Naters W. , Peters O. M. , Smith G. A. 
Published: September 2023

AbstractThe role of cyclin-dependent kinases (CDKs) that are ubiquitously expressed in the adult nervous system remains unclear. Cdk12 is enriched in terminally differentiated neurons where its conical role in the cell cycle progression is redundant. We find that in adult neurons Cdk12 acts a negative regulator of actin formation, mitochondrial dynamics and neuronal physiology. Cdk12 maintains the size of the axon at sites proximal to the cell body through the transcription of homeostatic enzymes in the 1-carbon by folate pathway which utilize the amino acid homocysteine. Loss of Cdk12 leads to elevated homocysteine and in turn leads to uncontrolled F-actin formation and axonal swelling. Actin remodeling further induces Drp1-dependent fission of mitochondria and the breakdown of axon-soma filtration barrier allowing soma restricted cargos to enter the axon. We demonstrate that Cdk12 is also an essential gene for long-term neuronal survival and loss of this gene causes age-dependent neurodegeneration. Hyperhomocysteinemia, actin changes, and mitochondrial fragmentation are associated with several neurodegenerative conditions such as Alzheimer’s disease and we provide a candidate molecular pathway to link together such pathological events.