bluuebunny/crossref_metadata_2025_split huggingface dataset:
Leishmaniose canine : le point de vue de l’interniste
Authors: Canonne-Guibert Morgane 
Published: June 2023

La leishmaniose est une maladie vectorielle zoonotique principalement décrite dans l’espèce canine et causée par Leishmania infantum. Chez le chien, l’expression clinique est variable et dominée par des signes cliniques cutanés. Néanmoins, la présence d’une atteinte rénale doit être systématiquement recherchée compte tenu des conséquences thérapeutiques et pronostiques qu’elle comprend : une protéinurie significative est ainsi présente chez au moins la moitié des cas et jusqu’à 40 % des chiens infectés sont azotémiques. Face à un chien infecté, l’évaluation exhaustive de la fonction rénale, la quantification d’une éventuelle protéinurie et la recherche d’une hypertension artérielle systémique doivent donc être automatiques. La confirmation d’une atteinte rénale conduit à une prise en charge médico-nutritionnelle spécifique en complément du traitement direct de l’infection parasitaire. Cette prise en charge spécifique est évidemment modulée en fonction de la gravité de la maladie rénale. Enfin, la programmation des suivis ultérieurs d’un chien infecté avec atteinte rénale secondaire doit respecter les recommandations IRIS.
Primär kutanes peripheres T-Zell Lymphom, nicht weiter spezifiziert (NOS), und erfolgreicher Einsatz von Brentuximab Vedotin
Authors: Makris Nikolaos , Finck Stefanie , Kirchner Kathrin , von den Driesch Peter 
Published: June 2023

ZusammenfassungDas primär kutane periphere T-Zell-Lymphom, nicht weiter spezifiziert (pcPTCL-NOS), ist eine seltene, zügig fortschreitende, maligne Erkrankung, die sich in schnell wachsenden Plaques oder Knoten manifestiert. Hier berichten wir über den Fall einer 42-jährigen Patientin, bei der nach histologischem Nachweis des pcPTCL-NOS trotz relativ niedriger prozentualer Expression von CD30-Antigen ein erfolgreicher therapeutischer Einsatz von Brentuximab Vedotin erfolgte. Nach 6 Wochen gab es eine rasche Besserung des Hautbefundes. Neben einer therapiebedingten Grad-1-Neuropathie an den Akren war Brentuximab Vedotin sehr gut verträglich.
Akupunktur bei Erkrankungen des rheumatischen Formenkreis
Authors: Kramer Sybille 
Published: June 2023

ZUSAMMENFASSUNGAuch Patienten mit rheumatisch-entzündlichen Erkrankungen äußern häufig den Wunsch nach einer Therapie mit komplementärmedizinischen Verfahren. Die Akupunktur kann hier eine geeignete Behandlungsform darstellen: Neben unzähligen randomisiert-kontrollierten Studien mit guten Ergebnissen in der Schmerztherapie, gibt es nun in der Literatur auch viele gute Hinweise auf eine Wirksamkeit in der additiven Therapie bei rheumatoider Arthritis. Dieser Artikel gibt einen Überblick, wann sich eine Behandlung mit Akupunktur eignen kann.
Joint velocity and density reconstruction of the Universe with nonlinear differentiable forward modeling
Authors: Bayer Adrian E. , Modi Chirag , Ferraro Simone 
Published: June 2023

Abstract
Reconstructing the initial conditions of the Universe from late-time observations has the
potential to optimally extract cosmological information. Due to the high dimensionality of the
parameter space, a differentiable forward model is needed for convergence, and recent advances
have made it possible to perform reconstruction with nonlinear models based on galaxy (or halo)
positions. In addition to positions, future surveys will provide measurements of galaxies'
peculiar velocities through the kinematic Sunyaev-Zel'dovich effect (kSZ), type Ia supernovae, the
fundamental plane relation, and the Tully-Fisher relation. Here we develop the formalism for
including halo velocities, in addition to halo positions, to enhance the reconstruction of the
initial conditions. We show that using velocity information can significantly improve the
reconstruction accuracy compared to using only the halo density field. We study this improvement
as a function of shot noise, velocity measurement noise, and angle to the line of sight. We also
show how halo velocity data can be used to improve the reconstruction of the final nonlinear
matter overdensity and velocity fields. We have built our pipeline into the differentiable
Particle-Mesh FlowPM package, paving the way to perform field-level cosmological
inference with joint velocity and density reconstruction. This is especially useful given the
increased ability to measure peculiar velocities in the near future.
Dark matter produced from right-handed neutrinos
Authors: Li Shao-Ping , Xu Xun-Jie 
Published: June 2023

Abstract
Right-handed neutrinos (RHNs) provide a natural portal
to a dark sector accommodating dark matter (DM). In this work, we
consider that the dark sector is connected to the standard model
only via RHNs and ask how DM can be produced from RHNs. Our framework
concentrates on a rather simple and generic interaction that couples
RHNs to a pair of dark particles. Depending on whether RHNs are light
or heavy in comparison to the dark sector and also on whether one
or both of them are in the freeze-in/out regime, there are many distinct
scenarios resulting in rather different results. We conduct a comprehensive
and systematic study of all possible scenarios in this paper. For
illustration, we apply our generic results to the type-I seesaw model
with the dark sector extension, addressing whether and when DM in
this model can be in the freeze-in or freeze-out regime. Some observational
consequences in this framework are also discussed.
Precision measurement of an electron pump at 2 GHz; the frontier of small DC current metrology
Authors: Giblin Stephen P , Yamahata Gento , Fujiwara Akira , Kataoka Masaya 
Published: June 2023

Abstract
A well-characterised sample of silicon tunable-barrier electron pump has been operated at a frequency of 2 GHz using a custom drive waveform, generating a pump current of 320 pA. Precision measurements of the current were made as a function of pump control parameters, using a blind protocol, over a 7 week campaign. The combined standard uncertainty for each

∼

10

h measurement was in the range

0.16
−
0.18

parts per million (ppm). The pump current exhibits a plateau along the exit gate voltage flat to approximately 0.15 ppm, but offset from ef by 0.2 ppm. This offset may be a sign of errors in the current traceability chain, indicating a limit to the accuracy of small current scaling using existing methods based on cryogenic current comparators.
Eco-concrete for obtaining “green” construction elements
Authors: Luca B I , Panțiru A , Timu A , Bărbuță M , Diaconu L I , Rujanu M , Diaconu A C 
Published: June 2023

Abstract
The building materials branch of the construction industry is continuously developing due to occurrence of new products which seek to improve the “green” character of buildings by using different types of wastes. Prefabricated products of different sizes such as blocks, panels, beams and other spatial elements can now be obtained with eco-materials. Concrete is the most used material in the building industry and thus it is necessary to diminish its environmental pollution. There are different ways for improving the “green” character of concrete, such as the addition of waste products of different types (fly ash, silica fume, slag, shredded tyre rubber, agricultural powder wastes, etc.) or by replacing some of the components (i.e. cement, aggregates) with eco-materials. Materials with pozzolanic properties (fly ash, silica fume, banana leaves powder, volcanic tuff, etc.) can, in certain proportions, replace the cement. In order to replace the aggregates, the substitution materials are obtained with sizes which are corresponding to the aggregate sort (polystyrene granules, shredded plastic recipients, agricultural wastes, etc). In the current article, the experimental results obtained on types of eco-concrete used for producing reinforced concrete beams are presented. The eco-concrete used for pouring the reinforced concrete beams contains the following materials: fly ash as replacement for the cement, metalic fibers, polyester fibers and hemp fibers. The beams models were tested in two point bending. The strength capacity and type of failure were analysed and compared as a function of the type of eco-concrete.
The 𝐧^{𝐭𝐡} iterate of a formal power series with linear term a primitive 𝐧^{𝐭𝐡} root of unity
Authors: Cohen Marshall , Monkam Galamo 
Published: June 2023

We give a very short proof of the Theorem: Suppose that

f
(
x
)
=

a
1

x
+

a
2

x
2

+
⋯

f(x) = a_1x + a_2x^2 + \cdots

is a formal power series with coefficients in an integral domain, and

a
1

a_1

is a primitive

n

t
h

n^{\mathrm {th}}

root of unity

(
n
∈

N

)

(n \in {\Bbb N})

. If the

n

t
h

n^{\mathrm {th}}

iterate

f

(
n
)

(
x
)
≡
f

(

f
(
⋯
f

(

f
(
x
)

)

⋯

)

f^{(n)}(x) \equiv f\big (f(\cdots f\big (f(x)\big )\cdots \big )

satisfies

f

(
n
)

(
x
)
=
x
+

b
m

x
m

+

b

m
+
1

x

m
+
1

+
⋯

f^{(n)}(x) = x + b_mx^m + b_{m + 1}x^{m + 1} + \cdots

, with

b
m

≠
0

b_m \neq 0

and

m
>
1

m > 1

, then

m
≡
1

(
mod

n
)

m \equiv 1 \pmod {n}

.
Operationalizing distribution as a key concept for public sphere theory. A call for ethnographic sensibility of different social worlds
Authors: Moe Hallvard 
Published: June 2023

AbstractThis article takes issue with public sphere theories’ lack of focus on the consequences of social inequality. Citizens divide the work of following politics between them, and we need a cohesive conceptualization of such divisions, through and beyond today’s intrusive media and with attention to social inequalities. Instead of ideals of fully informed individual citizens, I propose we take the empirical fact of distribution of citizens’ public connection as a starting point and anchor our theoretical ideals in the social world with an “ethnographic sensibility.” Doing so facilitates an operationalized concept of distribution of citizens’ public connection into four elements: issues, arenas, and communicative modes, which citizens variously rely on over time. With such an operationalization, we can assess when and for whom the distribution of public connection goes too far and disfavors certain citizens. This helps bring public sphere theory beyond the conundrum of our societies’ paradoxically uninformed citizens.
Bacteriophage-host interactions in Streptococcus thermophilus and their impact on co-evolutionary processes
Authors: Lavelle Katherine , McDonnell Brian , Fitzgerald Gerald , van Sinderen Douwe , Mahony Jennifer 
Published: June 2023

Abstract
Bacteriophages (or phages) represent a persistent threat to the success and reliability of food fermentation processes. Recent reports of phages that infect Streptococcus thermophilus have highlighted the diversification of phages of this species. Phages of S. thermophilus typically exhibit a narrow range, a feature that is suggestive of diverse receptor moieties being presented on the cell surface of the host. Cell wall polysaccharides, including rhamnose-glucose polysaccharides and exopolysaccharides have been implicated as being involved in the initial interactions with several phages of this species. Following internalization of the phage genome, the host presents several defences, including CRISPR-Cas and restriction and modification systems to limit phage proliferation. This review provides a current and holistic view of the interactions of phages and their S. thermophilus host cells and how this has influenced the diversity and evolution of both entities.
VSIG4 interaction with heparan sulfates inhibits VSIG4–complement binding
Authors: Ebstein Sarah Y , Rafique Ashique , Zhou Yi , Krasco Amanda , Montalvo-Ortiz Welby , Yu Lola , Custodio Luisaidy , Adam Rene C , Bloch Nicolin , Lee Ken , Adewale Funmilola , Vergata Dominic , Luz Antonio , Coquery Sebastien , Daniel Benjamin , Ullman Erica , Franklin Matthew C , Hermann Aynur , Huang Tammy , Olson William , Davis Samuel , Murphy Andrew J , Sleeman Matthew A , Wei Joyce , Skokos Dimitris 
Published: June 2023

Abstract
V-set and immunoglobulin domain-containing 4 (VSIG4) is a complement receptor of the immunoglobulin superfamily that is specifically expressed on tissue resident macrophages, and its many reported functions and binding partners suggest a complex role in immune function. VSIG4 is reported to have a role in immune surveillance as well as in modulating diverse disease phenotypes such as infections, autoimmune conditions, and cancer. However, the mechanism(s) governing VSIG4’s complex, context-dependent role in immune regulation remains elusive. Here, we identify cell surface and soluble glycosaminoglycans, specifically heparan sulfates, as novel binding partners of VSIG4. We demonstrate that genetic deletion of heparan sulfate synthesis enzymes or cleavage of cell-surface heparan sulfates reduced VSIG4 binding to the cell surface. Furthermore, binding studies demonstrate that VSIG4 interacts directly with heparan sulfates, with a preference for highly sulfated moieties and longer glycosaminoglycan chains. To assess the impact on VSIG4 biology, we show that heparan sulfates compete with known VSIG4 binding partners C3b and iC3b. Furthermore, mutagenesis studies indicate that this competition occurs through overlapping binding epitopes for heparan sulfates and complement on VSIG4. Together these data suggest a novel role for heparan sulfates in VSIG4-dependent immune modulation.
Predicting Pacific cod thermal spawning habitat in a changing climate
Authors: Bigman J S , Laurel B J , Kearney K , Hermann A J , Cheng W , Holsman K K , Rogers L A 
Published: June 2023

Abstract
Warming temperatures elicit shifts in habitat use and geographic distributions of fishes, with uneven effects across life stages. Spawners and embryos often have narrower thermal tolerances than other life stages, and are thus particularly sensitive to warming. Here, we examine the spatiotemporal variability of thermal spawning habitat for Pacific cod in the eastern Bering Sea. Specifically, we use bottom temperatures from downscaled global climate models coupled with an experimentally-derived hatch success and temperature relationship to predict how the spatial extent, mean latitude, and consistency of thermal spawning habitat has varied over time. Predictions are validated with observations of spawning adults and early larvae. We find that habitat availability has not increased in the past but is predicted to increase and shift northward in the future, particularly if no climate change mitigation occurs. Habitat hotspots are consistent across shorter time periods but do shift across the shelf by the end of the century such that highly suitable areas in the past and present are not predicted to be suitable in the future. This work highlights the importance of coupling experimental data with climate models to identify the complex and mechanistic dynamics among temperature, life histories, and ecology, particularly under climate change.
Foreword: Preventing COVID-19 Among the Immunocompromised Population
Authors: Willicombe Michelle 
Published: June 2023

Abstract
The COVID-19 pandemic represented 1 of the more significant and unique public health challenges facing the global community, particularly afflicting those with compromised immune systems. These immunocompromised individuals were readily recognized as a group at high risk of infection by SARS-CoV-2 and the associated severe outcomes of COVID-19. Although preventive strategies such as vaccination are important, initial clinical vaccine trials did not enroll immunocompromised individuals; in-depth evaluations of the safety, immunogenicity, and real-world outcomes associated with these vaccines were conducted in this population thereafter. As immunogenicity data of COVID-19 vaccination among this disparate group of individuals emerged, vaccination strategies were adapted to address outstanding challenges and further protect the entirety of this population. This 8-part journal supplement characterizes in-depth the mRNA-based COVID-19 vaccination strategies across the spectrum of immunocompromised individuals, focusing on the ongoing approaches to challenges facing this group as the pandemic continues to evolve.
Incidence of Cytomegalovirus Primary and Secondary Infection in Adolescent Girls: Results From a Prospective Study
Authors: Paris Robert , Apter Dan , Boppana Suresh , D’Aloia Maria , De Schrevel Nathalie , Delroisse Jean-Marc , Grassano Luca , Guignard Adrienne , Panackal Anil A , Roman Francois , Yu Jing , Yunes Elsa M , Dieussaert Ilse 
Published: June 2023

Abstract
Developing a vaccine to prevent congenital cytomegalovirus (CMV) infection and newborn disability requires an understanding of infection incidence. In a prospective cohort study of 363 adolescent girls (NCT01691820), CMV serostatus, primary infection, and secondary infection were determined in blood and urine samples collected at enrollment and every 4 months for 3 years. Baseline CMV seroprevalence was 58%. Primary infection occurred in 14.8% of seronegative girls. Among seropositive girls, 5.9% had ≥4-fold increase in anti-CMV antibody, and 23.9% shed CMV DNA in urine. Our findings provide insights on infection epidemiology and highlight the need for more standardized markers of secondary infection.
Playing in the clinical decision support sandbox: tools and training for all
Authors: Soares Andrey , Afshar Majid , Moesel Chris , Grasso Michael A , Pan Eric , Solomonides Anthony , Richardson Joshua E , Barone Eleanor , Lomotan Edwin A , Schilling Lisa M 
Published: June 2023

AbstractObjectivesIntroduce the CDS-Sandbox, a cloud-based virtual machine created to facilitate Clinical Decision Support (CDS) developers and implementers in the use of FHIR- and CQL-based open-source tools and technologies for building and testing CDS artifacts.Materials and MethodsThe CDS-Sandbox includes components that enable workflows for authoring and testing CDS artifacts. Two workshops at the 2020 and 2021 AMIA Annual Symposia were conducted to demonstrate the use of the open-source CDS tools.ResultsThe CDS-Sandbox successfully integrated the use of open-source CDS tools. Both workshops were well attended. Participants demonstrated use and understanding of the workshop materials and provided positive feedback after the workshops.DiscussionThe CDS-Sandbox and publicly available tutorial materials facilitated an understanding of the leading-edge open-source CDS infrastructure components.ConclusionThe CDS-Sandbox supports integrated use of the key CDS open-source tools that may be used to introduce CDS concepts and practice to the clinical informatics community.
American Burn Association (ABA) Burn Care Quality Platform (BCQP) and Large Data Set Analysis Considerations: A Practical Guide to Investigating Clinical Questions in Burns via Large Data Sets
Authors: Galicia Kevin E , Thompson Callie M , Lewis Aislinn E , Joyce Cara J , Hill David M , Schneider Jeffery C , Nyygard Rachel M , Harrington David M , Holmes James H , Moffatt Lauren T , Shupp Jeff W , Kubasiak John C 
Published: June 2023

Abstract
The Burn Care Quality Platform (BCQP) consolidates data previously collected from the National Burn Repository and the Burn Quality Improvement Program into a single registry. Its data elements and their associated definitions are tailored to create consistency across other national trauma registries, namely the National Trauma Data Bank implemented by the American College of Surgeons Trauma Quality Improvement Program (ACS TQIP). The BCQP now includes 103 participating burn centers and has captured data from 375,000 total patients as of 2021. With 12,000 patients entered under the current data dictionary, the BCQP represents the largest registry of its kind. On behalf of the American Burn Association Research Committee, the aim of this whitepaper is to provide a succinct overview of the BCQP, showcasing its unique features, strengths, limitations, and relevant statistical considerations. This whitepaper will highlight the resources available to the burn research community and offer insight on proper study design when preparing to conduct a large data set investigation for burn care. All recommendations herein were formulated through the consensus of a multidisciplinary committee and based on the available scientific evidence.
When does patent protection spur cumulative research within firms?
Authors: Arora Ashish , Belenzon Sharon , Marx Matt , Shvadron Dror 
Published: June 2023

Abstract
We estimate the effect of patent protection on follow-on investments in corporate scientific research. We exploit a new method for identifying an exogenous reduction in the protection a granted patent provides. Using data on public, research-active firms between 1990 and 2015, we find that firms respond to a decrease in patent protection by reducing follow-on research, as measured by a drop in internal citations to an associated scientific article. We study this effect across firms with varying commercialization capabilities and across varying thickness levels of markets for technology. We find that the effect is stronger in technologies where patents are traded less frequently. Our findings are consistent with a stylized model whereby patent protection is a strategic substitute for commercialization capability. Our results imply that stronger patents encourage follow-on research, but also shift the locus of research from big firms toward smaller firms and startups (JEL D22, O31, O32, O34).
Arthroscopic repair of knee cartilage defects with minced cartilage autograft: a 6-month follow-up case report study
Authors: Mitev Konstantin 
Published: June 2023

Abstract
Knee cartilage defects can cause significant pain and disability, leading to progressive degenerative changes if left untreated. Arthroscopic repair of these defects with minced cartilage autograft has emerged as a promising alternative to traditional surgical techniques. Articular cartilage was harvested from the edge of the osteochondral defect and from the edge of the supracondylar notch with a shaver. After that, the mixed cartilage was combined with prp in thrombinator were aplicated on the defect covered with fibrin glue. Postoperatively, the patient reported significant improvement in pain and function.
A crossroad between lexicography and terminology work: Knowledge organization and domain labelling
Authors: Costa Rute , Salgado Ana , Ramos Margarida , Almeida Bruno , Silva Raquel , Carvalho Sara , Khan Fahad , Tasovac Toma , Khemakhem Mohamed , Romary Laurent 
Published: June 2023

AbstractMORDigital project aims to encode the selected editions of Diccionario de Lingua Portugueza by António de Morais Silva, first published in 1789. Our ultimate goals are, on the one hand, to promote accessibility to cultural heritage while fostering reusability and, on the other hand, to contribute towards a more significant presence of lexicographic digital content in Portuguese through open tools and standards. The Morais dictionary represents a significant legacy, since it marks the beginning of Portuguese dictionaries, having served as a model for all subsequent lexicographic production. The team follows a new paradigm in lexicography, which results from the convergence between lexicography, terminology, computational linguistics, and ontologies as an integral part of digital humanities and linked (open) data. In the Portuguese context, this research fills a gap concerning searchable online retrodigitized dictionaries, built on current standards and methodologies which promote data sharing and harmonization, namely TEI Lex-0. The team will further ensure the connection to other existing systems and lexical resources, particularly in the Portuguese-speaking world.