bluuebunny/crossref_metadata_2025_split huggingface dataset:
Klinische und histopathologische Merkmale fortgeschrittener Plattenepithelkarzinome der Haut mit unterschiedlichem Ansprechen auf Cemiplimab
Authors: Hempel Conrad , Vladimirova Gabriela , Horn Susanne , Horn Lars‐Christian , Ziemer Mirjana 
Published: January 2025

ZusammenfassungHintergrundDie meisten, jedoch nicht alle Patienten mit inoperablem lokal fortgeschrittenem oder metastasiertem kutanem Plattenepithelkarzinom (cSCC) profitieren von Cemiplimab. Ziel unserer Studie war es, klinische und histopathologische Merkmale zu identifizieren, die das Ansprechen auf Cemiplimab vorhersagen.Patienten und MethodikWir analysierten 15 mit Cemiplimab behandelte Patienten hinsichtlich klinischer, demografischer, histopathologischer und immunhistochemischer Merkmale und korrelierten diese mit dem Ansprechen auf die Behandlung. Darüber hinaus wurde die Wirksamkeit und Sicherheit der Immun‐Checkpoint‐Therapie in unserer Kohorte bewertet.ErgebnisseUnsere Kohorte umfasste 12 Männer und 3 Frauen mit einem Durchschnittsalter von 78,1 Jahren. Die Mehrzahl der Tumoren (66,7%) befand sich im Kopf‐ und Halsbereich. Die Behandlung war insgesamt gut verträglich, mit nur einer Kolitis Grad 3. Es gab keinen Zusammenhang zwischen immunbedingten unerwünschten Ereignissen und dem Ansprechen auf die Behandlung. Non‐Responder waren im Durchschnitt jünger (69,4 vs. 82,5 Jahre). Eine Vorgeschichte von hämatologischen Malignomen korrelierte mit schlechterem Ansprechen. Hohe Mitoserate, schlechter Tumordifferenzierungsgrad, hohe Vimentin‐ und p53‐ sowie geringe E‐Cadherin‐Expression waren mit schlechterem Ansprechen verbunden. Umgekehrt korrelierten höhere Dichte intratumoraler Entzündungsinfiltrate, nekrotische Bereiche und schwächere immunhistochemische Expression von Mismatch‐Reparatur‐Proteinen mit besserem Ansprechen.SchlussfolgerungenCemiplimab ist eine sichere und wirksame Therapie, insbesondere bei älteren Patienten. Bei gut differenzierten Tumoren mit niedrigem Proliferationsindex, intratumoralem Entzündungsinfiltrat und Tumornekrose kann ein besseres klinisches Ansprechen vorhergesagt werden.
Überbrückung der Versorgungslücke durch Telemedizin: Pilotstudie zur Akzeptanz und Nutzung der Teledermatologie bei Urtikaria
Authors: Hindelang Michael , Sitaru Sebastian , Fischer Chiara , Biedermann Tilo , Zink Alexander 
Published: January 2025

ZusammenfassungHintergrundDie chronische spontane Urtikaria (CSU) beeinträchtigt die Lebensqualität der Patienten erheblich. Trotz Fortschritten bei Diagnose und Therapie ist die Behandlung immer noch unzureichend. Die Telemedizin bietet eine vielversprechende Lösung zur Verbesserung der Behandlung. Diese Pilotstudie bewertet die Akzeptanz und Nutzung eines digitalen Gesundheitskonzepts für die CSU, untersucht dessen Auswirkungen auf das Krankheitsmanagement und zeigt technische Herausforderungen auf.Patienten und MethodikIn diese prospektive Pilotstudie wurden CSU‐Patienten einer Universitätsklinik in Deutschland einbezogen. Über einen Zeitraum von 12 Monaten interagierten die Teilnehmer mit Ärzten über eine telemedizinische Plattform, welche die studienspezifische Intervention darstellte. Nach jeder dreimonatigen digitalen Visite wurden die Symptome und die Lebensqualität anhand von digitalen patientenberichteten Ergebnissen (ePROs) und Online‐Fragebögen bewertet. Am Ende bewerteten Patienten und Ärzte die allgemeine Zufriedenheit, die Benutzerfreundlichkeit der Plattform und die technischen Herausforderungen.Ergebnisse24 Patienten nahmen an der Studie teil. Die Mehrheit (92%) gab an, dass das digitale Konzept eine vielversprechende Alternative zu herkömmlichen Beratungsgesprächen sein könnte. Die Analyse von Beginn Ende der Studie ergab, dass die Krankheitskontrolle stabil blieb, während sich die Lebensqualität verbesserte. Alle Ärzte empfanden die digitale Anwendung als zuverlässig und zeitsparend.SchlussfolgerungenDiese Pilotstudie zeigt die Machbarkeit und hohe Akzeptanz eines digitalen Gesundheitskonzepts für das Management von CSU. Weitere Forschungen mit größeren Kohorten sind erforderlich, um eine breitere Anwendbarkeit zu ermitteln.
Papulonodular mucinosis: a systematic review on clinicopathologic characteristics, course and treatment options
Authors: Luo Si‐Yu , Wang Qin‐Xiao , Zhou Kai‐Yi , Deng Li‐Jia , Fang Sheng 
Published: January 2025

SummaryPapulonodular mucinosis (PNM) is a rare cutaneous mucinosis recognized as a rare variant of lupus erythematosus. There are no large‐scale cohort studies characterizing its clinicopathological features or evaluating the effectiveness of various treatment options. This study aimed to review the literature on PNMs to identify its clinical and histological features and treatment outcomes. The search includes studies from the PubMed, Embase, and Cochrane Library databases up to the March 1, 2024. A total of 37 studies, encompassing 44 patients, were included in the review. Of these, 20 were males and 24 females, with a mean age at diagnosis of 34.9 ± 1.92 years. PNM lesions are characterized by generalized papules, plaques, and nodules, and histopathologically, they show abundant mucin deposition throughout the dermis. The temporal relationship between PNM and SLE is variable. There is no evidence that SLE patients with PNM are more prone to organ involvement or increased disease activity. A combination of medical history, clinical features, and histopathological findings is essential for diagnosis; however, misdiagnosis is possible until lupus erythematosus (LE) becomes evident. Hydroxychloroquine and systemic glucocorticoids are the current mainstays of treatment for PNM, with most patients achieving partial or complete remission.
Sonic Hedgehog signaling regulates the optimal differentiation pace from early‐stage mesoderm to cardiogenic mesoderm in mice
Authors: Inoue Satoshi , Nosetani Moe , Nakajima Yoshiro , Sakaki Shinichiro , Kato Hiroki , Saba Rie , Takeshita Naoki , Nishikawa Kosuke , Ueyama Atsuko , Matsuo Kazuhiko , Shigeta Masaki , Kobayashi Daisuke , Iehara Tomoko , Yashiro Kenta 
Published: January 2025

AbstractSonic Hedgehog (Shh), encoding an extracellular signaling molecule, is vital for heart development. Shh null mutants show congenital heart disease due to left–right asymmetry defects stemming from functional anomaly in the midline structure in mice. Shh signaling is also known to affect cardiomyocyte differentiation, endocardium development, and heart morphogenesis, particularly in second heart field (SHF) cardiac progenitor cells that contribute to the right ventricle, outflow tract, and parts of the atrium. Despite extensive studies, our understanding remains incomplete. Notably, Shh signaling is suggested to promote cardiac differentiation, while paradoxically preventing premature differentiation of SHF progenitors. In this study, we elucidate the role of Shh signaling in the earliest phase of cardiac differentiation. Our meta‐analysis of single‐cell RNA sequencing suggests that cardiogenic nascent mesoderm cells expressing the bHLH transcription factor Mesp1 interact with axial mesoderm via Hh signaling. Activation of Hh signaling using a Smoothened agonist delayed or suppressed the differentiation of primitive streak cells expressing T‐box transcription factor T to Mesp1+ nascent mesoderm cells both in vitro and ex vivo. Conversely, inhibition of Hh signaling by cyclopamine facilitated cardiac differentiation. The reduction of Eomes, an inducer of Mesp1, by Hh signaling appears to be the underlying mechanism of this phenomenon. Our data suggest that SHH secreted from axial mesoderm inhibits premature differentiation of T+ cells to Mesp1+ nascent mesoderm cells, thereby regulating the pace of cardiac differentiation. These findings enhance our comprehension of Shh signaling in cardiac development, underscoring its crucial role in early cardiac differentiation.
Descriptive analysis of the use of and preferences for equine veterinary services
Authors: Gibson O. L. , Adam E. , Stowe C. J. 
Published: January 2025

SummaryBackgroundLittle is known about horse owners' use of and preferences for equine veterinary services, which are key components of the financial health of equine veterinary practices and challenges facing the profession.ObjectivesThe objective of this research is to describe horse owners' use of and preferences for equine veterinary services and assess their willingness to adapt to changes in delivery of services.Study designAn online survey was used to collect data for the study. The target audience was US residents aged 18+ who were financially responsible for at least one horse, pony, mule or donkey.MethodsThe online survey was distributed through participating organisations' social media and email lists. Microsoft Excel 16 was used to tabulate summary statistics.ResultsThe survey received a total of 4915 usable responses from every state in the United States. Most respondents are financially responsible for one to five horses, have a primary equine veterinarian and are visited by a veterinarian two to four times per year. Low rates of equine health savings accounts and health insurance may limit financial access to veterinary care. The majority of respondents report a willingness to accommodate deviations from traditional delivery of services. The most common maximum willingness‐to‐pay for annual vaccinations was $150, lameness exams was $200 and emergency colic surgery was $5000.Main limitationsThe response rate cannot be computed due to the distribution method. The representativeness of the sample cannot be determined due to lack of information on the horse owning population. In stated preference studies, hypothetical bias is common.ConclusionsThe results from this survey provide the first‐known documented evidence on the utilisation of equine veterinary services in the United States, willingness to adapt to changes and willingness to pay for three sample services. These data can inform the profession on attitudes towards services provided.
Assessing Short‐ and Long‐Term Anthropogenic Threats to a Reintroduced Fish in a Restored Urban Riverscape
Authors: Sears Mary M. , Myers Randall A. , Nisbet Mitchell T. , Tidwell M. Travis , Troia Matthew J. 
Published: January 2025

ABSTRACT

Understanding which species can persist in human‐modified environments is essential to biodiversity conservation in the Anthropocene. In urbanised environments, many stressors limit the persistence of imperilled native species via impacts on the abiotic and biotic environment. Habitat restoration followed by reintroduction of native species may be an effective strategy to maintain or even regenerate biodiversity in urbanised environments, but few studies have assessed these two conservation strategies concomitantly in urban freshwater ecosystems.

We assessed short‐term population dynamics and habitat associations of an endemic species of conservation concern, Guadalupe bass (Micropterus treculii, ‘GB’), that was reintroduced in a restored urbanised riverscape already occupied by a generalist congener, largemouth bass (M. salmoides, ‘LMB’). We performed four seasonal surveys of habitat association and one capture‐mark‐recapture survey of the two species at eight sites distributed along a 17 km reach of the San Antonio River within San Antonio, Texas—the seventh largest city in the United States.

Detection of multiple size classes at all eight sites indicated that reintroduced GB have dispersed throughout this riverscape and are naturally recruiting. Juvenile GB were associated with restored riffles and transitioned to pools as adults—an ontogenetic habitat shift documented in rivers draining natural landscapes elsewhere in the GB native range. By contrast, juvenile and adult LMB were associated with pool habitats. Our results indicated that the construction of riffle habitats along this restored riverscape provide essential habitat for juvenile GB that was unavailable prior to restoration. Habitat overlap of adult bass indicated the potential for competition between the two species; however, GB body condition did not vary with LMB abundance across sites or seasons.

Next, we assessed long‐term stressors by comparing dispersal barriers, hydrologic alteration, pollution proxies and fish kill frequencies in the urbanised restored riverscape to minimally‐impacted riverscapes throughout the native GB range. The urbanised restored riverscape was subject to more barriers, flashier hydrology and more pollution; however, these stressors did not translate to more frequently‐documented fish kills in our study.

We showed that restoration of instream habitat followed by reintroduction of native species enhanced urbanised biodiversity. Monitoring population responses to multiple urbanised stressors and mitigating those that threaten the long‐term persistence of reintroduced species remains important.
Entre el Clóset y la (Des)colonización: Explorando la Satisfacción Laboral LGBT+ en el Contexto Chileno
Authors: Jeldes Fabiola , Montenegro Helena , Caceres Javier 
Published: January 2025

ABSTRACTAAnte un contexto global más diverso, se ha vuelto más evidente que las empresas cuentan con un mayor número de empleados LGBT+ en sus filas. Sin embargo, aún se desconocen los factores que influyen en la satisfacción laboral de los empleados LGBT+, y existe poca literatura sobre por qué y cuándo los empleados LGBT+ entran o salen del closet en el lugar de trabajo, influidos por el contexto de (des)colonización que Chile ha experimentado en los últimos años. Este artículo explora los principales factores que determinan la satisfacción laboral de los empleados LGBT+, y la dinámica que adoptan para entrar o salir del closet. Los datos se recopilan y analizan mediante la técnica de incidentes críticos (CIT). Los resultados muestran que los factores de Herzberg operan en contextos modernos, complejos y heterogéneos. Tanto los factores motivacionales como los higiénicos están involucrados en la satisfacción laboral de los empleados LGBT+ y su influencia depende de si el contexto se encuentra (des)colonizado. Por último, identificamos un nuevo factor para estos empleados minoritarios, al que llamamos apertura contextual, que está vinculado con procesos de descolonización que contribuyen a la satisfacción laboral de los empleados LGBT+.
“After Cutting It, Things Have Never Remained the Same”: A Qualitative Study of the Perspectives of Amputees and Their Caregivers
Authors: Ohenewa Esther , Yendork Joana Salifu , Amponsah Benjamin , Owusu‐Ansah Frances Emily 
Published: January 2025

ABSTRACTIntroductionPhysical and emotional loss from amputation and associated physical disability are associated with adverse physical and psychological experiences. However, little research, within the Ghanaian context, has focused on the impact of amputation on the well‐being of amputees and their caregivers and the coping strategies they use to mitigate challenges experienced. Therefore, the present study explored the impact of amputation on the well‐being of amputees and caregivers, and the coping strategies they employ to manage distress associated with amputation and caregiving.MethodsThe aim of this present study was explored using a qualitative descriptive design. Twenty (20) participants (comprising 10 amputees and 10 caregivers) responded to a semi‐structured interview guide.ResultsFindings show that whereas amputees experienced phantom limb sensation and loss of job, caregivers reported economic hardship and fear. Though stress was a common experience, the source of stress was different for amputees and caregivers. Regarding coping, whereas amputees used social distancing, social reference and social support to cope with their traumatic ordeal, caregivers simply coped by encouraging themselves. Both amputees and caregivers used religious coping.ConclusionAmputees and their caregivers experience varied stressors yet whereas the amputees get the needed support to deal with their predicament, caregivers lack adequate support.Patient or Public ContributionThe findings underscore the need for diverse support systems and psychoeducation on adaptive coping strategies for amputees and caregivers.
Comparative study of management strategies for immune checkpoint inhibitor‐induced inflammatory arthritis: rheumatologists versus oncologists
Authors: Yoon Jang S. , Zhao Frances , Masood Hafsa , De Silva Ravini , Binns Jessie , Atkinson Victoria , Thomas Ranjeny , Terrill Matthew 
Published: January 2025

AbstractBackgroundImmune checkpoint inhibitors (ICIs) have significantly improved cancer treatment outcomes but are associated with immune‐related adverse events (irAEs), such as inflammatory arthritis (ir‐IA). Management of ir‐IA is evolving, with corticosteroids as the primary treatment, though some cases require steroid‐sparing agents.AimsThis study aimed to compare initial mean prednisolone doses and disease persistence over 12 months in patients with rheumatoid arthritis (RA)‐like ir‐IA managed by rheumatologists or oncologists.MethodsThis retrospective observational study involved patients who developed RA‐like ir‐IA after ICI treatment for advanced cancers between September 2015 and January 2019 at a tertiary hospital in Brisbane, Australia. Patient records were reviewed up to January 2020 to evaluate chronicity. Data were collected, and statistical analyses compared the management between rheumatologists and oncologists.ResultsA total of 871 patients received ICI and 246 had irAEs, with 20 developing RA‐like ir‐IA. Nine were managed by an oncologist and 11 by a rheumatologist. The mean dose of prednisolone commenced by a rheumatologist was 14 mg compared to 53.3 mg by an oncologist (P = 0.0058). Patients managed by a rheumatologist were more likely to receive conventional synthetic disease‐modifying anti‐rheumatic drugs (csDMARD) (odds ratio 16, P = 0.023). Thirteen patients required ongoing maintenance treatment, while seven had resolution within 12 months of disease onset.ConclusionsRA‐like ir‐IA comprised 8% of ICI‐related irAEs. During the study period, patients managed by rheumatologists received lower initial prednisolone doses and more frequent csDMARD than oncologists. A multidisciplinary involvement between rheumatologists and oncologists in the event of ir‐IA is crucial.
Rapid Review of Literature Reporting the Experience of Patient and Public Involvement in Prison and Forensic Mental Health Research
Authors: Rutherford Rosie , Pashley Susannah , Bowes Nicola , Heggs Daniel , Cornwell Rosie 
Published: January 2025

ABSTRACTHealth research authorities around the world are increasingly committed to embedding public involvement in health and social care research. However, such involvement in internationally published prison and forensic mental health research remains rare. It is therefore particularly important to understand how people are experiencing collaborative research in this field, barriers they may encounter and how these might be overcome. The aim of this review is to explore how academic, practitioner and lived‐experience researchers have experienced collaborating on prison and forensic mental health research since a previous review of the topic in 2016. A rapid review of literature was completed by searching three databases (MEDLINE, EMBASE and PsycINFO) between 2016 and July 2023 in addition to Google and Google Scholar searches and hand searching the reference lists of all screened‐in documents. We used Reflexive Thematic Analysis to review the screened‐in papers. We had lived‐experience involvement in this study, which is outlined in our Supporting Information. The database search returned 733 unique articles. Internet searches revealed 10 potentially relevant documents. 20 documents were eligible for inclusion; 15 journal articles, three book chapters, a whole book and a PhD thesis. In the analysis, four overarching themes were developed: the positive psychological impact on lived‐experience researchers; it is interpersonally, emotionally and practically challenging; facilitators of the collaborative research process; and positive impact of involvement on the research. Our findings build on the previous review by providing evidence that collaborating on research can have a positive psychological impact on people with lived experience in this setting. It also documents further challenges that are unique to the forensic setting. There was minimal reporting of the experiences of forensic mental health patients involved in research; most included documents focused the experiences of current or former prisoners. Further studies in the topic area are still needed, which utilise a research method to analyse the experiences of conducting collaborative research.
Experiences With End‐of‐Life Care for Patients With Pre‐Existing Severe Mental Disorders, Their Relatives, and Healthcare Professionals
Authors: Bøndergaard Kirstine , Møller Jane Ege , Nielsen Mette Kjærgaard , Videbech Poul , Neergaard Mette Asbjoern 
Published: January 2025

ABSTRACTKnowledge is needed about end‐of‐life care among patients with pre‐existing severe mental disorders: Schizophrenia, bipolar disorder, and depression. This study aimed to explore the experiences with end‐of‐life care for patients with severe mental disorders, their relatives, specialised palliative care nurses and physicians, and general practitioners. Twenty semi‐structured interviews were conducted and analysed using reflexive thematic analysis, hereby six interviews with patients, three with relatives, five with general practitioners, and six with specialised palliative healthcare professionals. Patients were selected with help from healthcare professionals. Four main themes were produced: thoughts about the future, healthy relations in end‐of‐life, changes in psychiatric condition in end‐of‐life, and the role of openness. Patients with severe mental disorders had wishes and fears for the future, and all participants expressed that healthy relations were crucial for patients at the end‐of‐life. However, sometimes this was challenged by prior complex relationships. It differed whether patients experienced a change in their psychiatric condition after having a terminal disease. Openness about severe mental disorders and end‐of‐life were regarded as important. Having the opportunity to openly discuss both wishes, fears, and mental disorders with healthcare professionals and having healthy relations are important for patients with severe mental disorders at the end‐of‐life. Insecurity about severe mental disorders among specialised palliative care professionals may lead to less openness about severe mental disorders. To optimise end‐of‐life care, patients need professionals to be present and available to discuss problems related to social, physical, existential, and psychiatric conditions.