bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of Laryngeal Sensory Function using a Tactile Aesthesiometer in Healthy Adults
Authors: Ma Yue , Kidane Joseph , Gochman Grant E. , Bracken David J. , Strohl Madeleine P. , Rosen Clark A. , Young VyVy N. 
Published: January 2023

IntroductionLaryngeal sensory function in healthy adults was assessed through the delivery of tactile stimuli using Cheung–Bearelly monofilaments.Methods37 healthy adults were recruited with 340 tactile stimuli analyzed. Four calibrated tactile stimuli were delivered to three laryngeal sites: false vocal fold (FVF), aryepiglottic fold (AEF), and lateral pyriform sinus (LPS). Primary outcome was the elicitation of laryngeal adductor reflex (LAR). Secondary outcomes were gag, patient‐reported laryngeal sensation (PRLS), and perceptual strength. Analysis was performed with mixed effects logistic regression modeling.ResultsPositive LAR was observed in 35.7%, 70.2%, and 91.2% of stimuli at LPS, AEF, and FVF respectively. LAR rates were significantly associated with laryngopharyngeal subsite (p < 0.001), tactile force (p = 0.001), age (p = 0.022) and sex (p = 0.022). LAR, gag, PRLS, and perceptual strength significantly increased as a more medial laryngeal subsite was stimulated and as stimulus force increased. Each of the ten years of age increase was associated with 19% reduction in odds of LAR (aOR = 0.81, 95% CI [0.68, 0.97]; p = 0.022). Male gender was associated with a 55% reduction in odds of LAR (aOR = 0.45, 95% CI [0.23, 0.89]; p = 0.022).ConclusionLAR elicitation capability decreases in the male gender, aging, and a more lateral subsite. This study provides insight into the pathophysiology of hypo‐ and hyper‐sensitive laryngeal disorders and is paramount to making accurate diagnostic assessments and finding novel treatment options for various laryngological disorders. Laryngoscope, 133:2525–2532, 2023
A study on the lubrication effects of nano‐TiO2 additive water‐based lubricants during rolling of ferritic stainless steel strips
Authors: Sun Xiaoyu , Ma Xiaoguang , Ma Linan , Zhou Cunlong , Li Jinghui , Zhang Mingya , Zhao Jingwei 
Published: January 2023

AbstractIn the present work, a comparison between traditional oil‐in‐water (O/W) based lubricant and nano‐TiO2 additive water‐based lubricants was made to explore the lubrication effects during rolling of ferritic stainless steel (FSS) strips. The results show that marked reduction in rolling force and improvement in the surface quality can be achieved by utilisation of water‐based nanolubricant, which can be attributed to the synergism of rolling effect, mending effect, polishing effect and protection film. An optimal concentration of 3.0 wt% TiO2 nanoparticles is found to exhibit excellent lubrication effects with sufficient nanoparticles at real contact regions without aggregation, leading to 10% reduction in the surface roughness during rolling of FSS strips.
Development and CT image‐domain validation of a computational lung lesion model for use in virtual imaging trials
Authors: Sauer Thomas J. , Bejan Adrian , Segars Paul , Samei Ehsan 
Published: January 2023

AbstractPurposeComputational abnormalities (e.g., lesion models) for use in medical imaging simulation studies are frequently generated using data collected from clinical images. Although this approach allows for highly‐customizable lesion detectability studies on clinical computed tomography (CT) data, the ground‐truth lesion models produced with this method do not provide a sufficiently realistic lesion morphology for use with current anthropomorphic simulation studies. This work is intended to demonstrate that the new anatomically‐informed lesion model presented here is not inferior to the previous lesion model under CT imaging, and can therefore provide a more biologically‐informed model for use with simulated CT imaging studies.MethodsThe lesion model was simulated initially from a seed cell with 10 μm diameter placed in an anatomical location within segmented lung CT and was allowed to reproduce locally within the available solid angle in discrete time‐intervals (corresponding to synchronous cell cycles) up to a size of ∼200 μm in diameter. Daughter cells of generation G were allowed also to reproduce on the next available time‐step given sufficient space. At lesion sizes beyond 200 μm in diameter, the health of subregions of cells were tracked with a Markov chain technique, indicating which regions were likely to continue growing, which were likely stable, and which were likely to develop necrosis given their proximity to anatomical features and other lesion cells. For lesion sizes beyond 500 μm, the lesion was represented with three nested, triangulated surfaces (corresponding to proliferating, dormant, and necrotic regions), indicating how discrete volumes of the lesion were behaving at a particular time. Lesions were then assigned smoothly‐varying material properties based on their cellular level health in each region, resulting in a multi‐material lesion model. The lesions produced with this model were then voxelized and placed into lung CT images for comparison with both prior work and clinical data. This model was subject to an observer study in which cardiothoracic imaging radiologists assessed the realism of both clinical and synthetic lesions in CT images.ResultsThe useable outputs of this work were voxel‐ or surface‐based, validated, computational lesions, at a scale clearly visible on clinical CT (3–4 cm). Analysis of the observer study results indicated that the computationally‐generated lesions were indistinguishable from clinical lesions (AUC = 0.49, 95% CI = [0.36, 0.61]) and non‐inferior to an earlier image‐based lesion model—indicating the advantage of the model for use in both hybrid CT images and in simulated CT imaging of the lungs.ConclusionsResults indicated the non‐inferiority of this model as compared to previous methods, indicating the utility of the model for use in both hybrid CT images and in simulated CT imaging.
One Health challenges for pig reproduction
Authors: Peltoniemi Olli , Tanskanen Topi , Kareskoski Maria 
Published: January 2023

AbstractThe current state of the world challenges pig reproduction as an important part of One Health, which involves interrelationships between animal, human and environmental health. The One Health concept underlines a comparative aspect in reproductive physiology and disease occurrence, bridging knowledge from one species to another. Seasonal changes in the environment affect pig reproduction and climate change may further strengthen those effects. Endocrine‐disrupting chemicals (EDCs), and specifically phthalates and heavy metals, interfere with endocrine function, and thereby sexual behavior, fertilization capacity and steroidogenesis. Reproductive infections and extended semen storage are important indications for antimicrobial use. Innovative solutions are needed to explore alternatives to antimicrobials. Efforts to ensure reproductive efficiency have prolonged farrowing as litter size has doubled over the past three decades, compromising immune transfer and welfare. Physiological, metabolic and programming related events around parturition are key areas for future One Health research in pig reproduction. In conclusion, climate change challenges reproductive management and breeding. More resilient pigs that can tolerate harsh environment but maintain high reproductive performance are needed. EDCs continue to grow as an environmental challenge for reproductive management and alternatives to antibiotics will be required.
Hybrid Phosphine/Amino‐Acid Ligands Built on Phenyl and Ferrocenyl Platforms: Application in the Suzuki Coupling of o‐Dibromobenzene with Fluorophenylboronic Acid
Authors: Radal Léa , Almallah Hamze , Labonde Marine , Roger Julien , Cattey Hélène , Sabbadin Henri , Amardeil Régine , Pirio Nadine , Hierso Jean‐Cyrille 
Published: January 2023

AbstractWe describe the synthesis and characterization of two classes of hybrid phosphino ligands functionalized with amino ester or amino acid groups. These compounds are built either on a rigid planar phenyl platform or on a functionalized – conformationally controlled – rotational ferrocene backbone. Modifications at the −PR2 phosphino groups (R=aryl and alkyl, with various steric bulk, Ph, Mes, i‐Pr, Cy) and at the amino acid/amino ester functions are reported, showing a valuable high modularity. The coordination chemistry of these compounds regarding palladium and gold was investigated, in particular with respect to the coordination mode of the phosphino groups and the preferred interaction with metals for the amino ester and amino acid functions. For all the hybrid ligands, based either on ferrocenyl or phenyl platforms, the (P,N)‐chelating effect dominates in solution for coordination to Pd(II), while linear P−Au(I) complexes without interaction with the amino groups are assumed. The investigation of the catalytic activity of these new ligands in the demanding palladium‐catalyzed Suzuki–Miyaura coupling of o‐dibromoarenes with fluorophenylboronic acid underlined the importance of the amino ester dicyclohexylphosphinoferrocene for avoiding the deleterious homocoupling and arene oligomerization side‐reactions that were otherwise observed with the other phosphine ligands.
Synthesis and characterization of a novel double network hydrogel based on gellan‐gum crosslinked by octavinyl polyhedral oligomeric silsesquioxane for heavy metal removal
Authors: Pourjalili Navid , Bagheri Marandi Gholam , Kurdtabar Mehran , Rezanejade Bardajee Ghasem 
Published: January 2023

AbstractIn this study, we demonstrated a new design technique for producing DNNH based on gellan‐gum crosslinked by octavinyl polyhedral oligomeric silsesquioxane. Incorporating OV‐POSS nanoparticles as cross‐linkers into the first and second networks created strong coordination contacts and improved mechanical performance with 90% water. pH and contact time affect DNNH swelling, Ni(II), and Pb(II) removal. The resulting hydrogels were characterized by FT‐IR, SEM, XRD, and TGA analyzes. The capacity of the hydrogel to adsorb Ni(II) and Pb(II) is 213.66 and 132.55 mg/g, respectively, according to the adsorption isotherm model. The usefulness of kinetic and isotherm investigations, notably the pseudo‐second‐order model and the Langmuir model, for the adsorption of the aforementioned contaminants, was proven. Ni(II) and Pb(II) adsorption is spontaneous and endothermic, according to the study. The hydrogel's adsorption–desorption reusability was renewed five times. As a consequence, the generated hydrogel is recognized as a good adsorbent for aqueous Ni(II) and Pb(II) adsorption.
Integrated metabolic and transcriptomic profiles reveal the germination‐associated dynamic changes for the seeds of Cassia obtusifolia L.
Authors: Chen Biying , Shi Biru , Ge Xiaoyan , Fu Zhifei , Yu Haiyang , Zhang Xu , Liu Caixiang , Han Lifeng 
Published: January 2023

AbstractIntroductionThe seeds of Cassia obtusifolia L. (Cassiae [C.] semen) have been widely used as both food and traditional Chinese medicine in China.ObjectivesWe aimed to analyze the metabolic mechanisms underlying C. semen germination.Materials and MethodsDifferent samples of C. semen at various germination stages were collected. These samples were subjected to 1H‐NMR and UHPLC/Q‐Orbitrap‐MS‐based untargeted metabolomics analysis together with transcriptomics analysis.ResultsA total of 50 differential metabolites (mainly amino acids and sugars) and 20 key genes involved in multiple pathways were identified in two comparisons of different groups (36 h vs 12 h and 84 h vs 36 h). The metabolite–gene network for seed germination was depicted. In the germination of C. semen, fructose and mannose metabolism was activated in the testa rupture period, indicating more energy was needed (36 h). In the embryonic axis elongation period (84 h), the pentose and glucuronate interconversions pathway and the phenylpropanoid biosynthesis pathway were activated, which suggested some nutrient sources (nitrogen and sugar) were in demand. Furthermore, oxygen, energy, and nutrition should be supplied throughout the whole germination process. These global views open up an integrated perspective for understanding the complex biological regulatory mechanisms during the germination process of C. semen.
Holographic recordings without compromise
Authors: Trotzky Stefan , Waasem Niklas 
Published: January 2023

AbstractWidely tunable continuous‐wave optical parametric oscillator (OPO) systems help meet the demands on holographic optical elements (HOEs) for many use cases, including head‐up displays and augmented reality devices. The wide tuning range allows for direct adjustment of the replay wavelength with little to no need for modification of the holographic recording geometry. HOEs fabricated using these OPO systems in conjunction with advanced photopolymer materials offer precisely controlled replay properties and exceptional diffraction efficiency.
Antimicrobial Peptide Pt5‐1c Promotes Keratinocyte Migration and Proliferation via EGFR‐mediated Akt/MAPK/STAT3 pathways
Authors: Wu Fei , Song Lili , Gong Yi , Wang Yubing , Li Hongyan , Zhang Shicui 
Published: January 2023

AbstractKeratinocytes, as the most dominant cell type in the epidermis, play multiple roles in skin wound healing. Recently, we have shown that a short antimicrobial peptide Pt5‐1c can promote skin wound healing via enhancing fibroblast proliferation and migration in vitro, and accelerating re‐epithelialization of murine dermal wounds in vivo.[1] However, its effects on keratinocytes is unknown. Here we clearly showed that Pt5‐1c markedly enhanced keratinocyte migration and proliferation. Moreover, Pt5‐1c stimulated keratinocyte activation by inducing the phosphorylation of epidermal growth factor receptor (EGFR), Akt, extracellular signal‐regulated kinase (ERK), p38, and signal transducer and activator of transcription 3 (STAT3) in keratinocytes. Importantly, Pt5‐1c also increased collagen production, stimulated cell proliferation, and enhanced the phosphorylation of Akt, p38 and STAT3 in the wound skin tissues. These together indicate that Pt5‐1c can promote keratinocyte migration and proliferation via activation of EGFR‐mediated Akt, MAPK, and STAT3 pathways, thereby contributing to skin wound healing.
Can we influence the neurological development and hair cortisol concentration of offspring by reducing the stress of the mother during pregnancy? A randomized controlled trial
Authors: Puertas‐Gonzalez Jose A. , Romero‐Gonzalez Borja , Mariño‐Narvaez Carolina , Gonzalez‐Perez Raquel , Sosa‐Sanchez Isis O. , Peralta‐Ramirez Maria Isabel 
Published: January 2023

AbstractThe objective was to evaluate the effects of a stress management cognitive behavioural therapy followed during pregnancy on subsequent childhood on hair cortisol at birth and on neurodevelopment and Hair Cortisol Concentrations (HCC) at 6 months of age. The study sample included 48 pregnant women, divided into two groups: 24 women in the Therapy Group (TG) and 24 women who received standard pregnancy care (control group (CG); CG). To test the therapy efficacy, an evaluation of the HCC and psychological stress, psychopathological symptomatology and resilience was conducted before and after the treatment. The level of cortisol in their hair was obtained during pregnancy and that of their babies at birth. Six months after birth, a cortisol sample was taken from the hair and the babies' neurodevelopment was evaluated based on a Bayley‐III test. The TG presented reductions in psychological stress and psychopathological symptomatology after treatment. On the other hand, the CG increased their cortisol concentrations between the pre and post intervention, remaining stable in the TG. Moreover, results showed that TG babies had lower cortisol concentrations at birth and obtained significantly higher cognitive and motor development scores at 6 months. These findings support that providing psychological care to pregnant women may not only have a benefit on these women's mental state, but may also benefit the neurodevelopment of their offspring.
Navigating windows of opportunity: The role of international experience
Authors: Garrido Elisabet , Giachetti Claudio , Maicas Juan P. 
Published: January 2023

AbstractResearch SummaryScholars have noted that pronounced changes in consumer demand and technology often offer firms temporary opportunities to strengthen their performance vis‐à‐vis rivals. This article contributes to the literature on windows of opportunity from an organizational learning perspective. It investigates whether the depth and breadth of a firm's international experience with pronounced changes in demand conditions (demand windows) and technologies (technological windows) affect its ability to take advantage of such changes within a country to increase its market share. The results, based on a sample of 615 telecommunication companies competing in 124 countries, suggest that mainly two out of four dimensions of international experience help firms to exploit windows of opportunity in a country.Managerial SummaryWhat can help multinational companies (MNCs) to navigate periods of marked changes in demand and technology? When an MNC encounters a marked change in demand or technology in a country, it may have already experienced in the past many or just a few of these events, depending on its international footprint, and this serves to assess the MNC's international experience with such changes. Using data on telecommunication companies, we show that both (a) an MNC's repeated exposure to a certain type of change over time (depth of international experience) and (b) the variety of changes an MNC has been exposed to (breadth of international experience) in international markets may help the MNC to obtain market share advantages when such changes occur in a country.
Covalent Pyrimidine Frameworks via a Tandem Polycondensation Method for Photocatalytic Hydrogen Production and Proton Conduction
Authors: Zhong Yifei , Li Chao , Yang Fan , Guan Lijiang , Jin Shangbin 
Published: January 2023

AbstractThe development of heteroaromatic conjugated porous polymers (H‐CPPs) have received enormous research interests, because of the important functional roles of the heteroatoms in photocatalysis and proton conduction. However, due to the synthetic challenges deriving from the stable structures, the structural diversity and synthetic methods of them are still limited. Herein, a new type of H‐CPPs, covalent pyrimidine frameworks (CPFs), via an efficient tandem polycondensation reaction between aldehyde, acetyl, and amidine monomers is reported. The resulting CPFs are bridged by pyrimidine units, rich of nitrogen atoms and can be structurally regulated on demand. The CPFs are shown to be active photocatalysts for hydrogen evolution from methanol via a photo‐thermo‐catalysis process, achieving an excellent hydrogen evolution rate of 5282.8 µmol h−1 g−1. The CPFs can be further processed into a mixed matrix membrane, displaying an excellent proton conductivity of 1.30 × 10−2 S cm−1 at 413 K under anhydrous condition.
High Throughput Confined Migration Microfluidic Device for Drug Screening
Authors: Yang Zihan , Zhou Zhihang , Si Tongxu , Zhou Zhengdong , Zhou Li , Chin Y. Rebecca , Zhang Liang , Guan Xinyuan , Yang Mengsu 
Published: January 2023

AbstractCancer metastasis is the major cause of cancer‐related death. Excessive extracellular matrix deposition and increased stiffness are typical features of solid tumors, creating confined spaces for tumor cell migration and metastasis. Confined migration is involved in all metastasis steps. However, confined and unconfined migration inhibitors are different and drugs available to inhibit confined migration are rare. The main challenges are the modeling of confined migration, the suffering of low throughput, and others. Microfluidic device has the advantage to reduce reagent consumption and enhance throughput. Here, a microfluidic chip that can achieve multi‐function drug screening against the collective migration of cancer cells under confined environment is designed. This device is applied to screen out effective drugs on confined migration among a novel mechanoreceptors compound library (166 compounds) in hepatocellular carcinoma, non‐small lung cancer, breast cancer, and pancreatic ductal adenocarcinoma cells. Three compounds that can significantly inhibit confined migration in pan‐cancer: mitochonic acid 5 (MA‐5), SB‐705498, and diphenyleneiodonium chloride are found. Finally, it is elucidated that these drugs targeted mitochondria, actin polymerization, and cell viability, respectively. In sum, a high‐throughput microfluidic platform for screening drugs targeting confined migration is established and three novel inhibitors of confined migration in multiple cancer types are identified.
Solvent Role of Ionic Liquids in Fundamental Chemical Reaction Dynamics Analyzed by Time‐Resolved Spectroscopy
Authors: Fujii Kaori , Kimura Yoshifumi 
Published: January 2023

AbstractIonic liquids (ILs), which are used as solvents for chemical reactions, are different from conventional organic solvents owing to their designability. Physicochemical parameters of the ILs, such as polarity and viscosity, that affect chemical equilibria and reaction kinetics can be tuned by changing the combination of anions and cations or by varying the lengths of the alkyl chains present in the cations. We were interested in knowing how these physicochemical parameters affect fundamental chemical reactions in ILs. Therefore, in this personal account, we investigate our recent work on two different photochemical reactions in ILs, namely excited‐state intramolecular proton transfer of hydroxyflavone and photodissociation of aminodisulfide, using time‐resolved spectroscopic techniques. Interestingly, the roles of the ILs in these chemical reactions are quite different. The effect of the cationic species of the ILs (i. e., the head groups and number of alkyl carbons) on the solvation environment upon photoexcitation and reaction rate are discussed.
Ataxia and muscle weakness after thiopental anaesthesia in a horse being treated with fluconazole
Authors: Aguilar‐Catalan Adrià , Costa‐Farré Cristina , Leiva Marta , Murison Pamela J. 
Published: January 2023

AbstractAn 8‐year‐old, male, neutered Argentinian polo pony underwent two ocular surgeries due to a fungal abscess. The horse was on treatment with fluconazole before and during the time when the two anaesthetic procedures took place. The only difference between anaesthetic events was the induction agent. During the first anaesthetic procedure, ketamine was used. However, during the second anaesthetic procedure, due to ocular fragility sodium thiopental was preferred to avoid increase in intraocular pressure. The first anaesthetic duration was 130 minutes, and standing was achieved after 20 minutes of isoflurane discontinuation, with no complications. The second anaesthetic procedure lasted for 60 minutes, but standing was not achieved until 70 minutes after isoflurane discontinuation. The horse was ataxic with muscle weakness for 6 hours after standing. However, the horse recovered successfully and was discharged 2 months after the first surgical procedure.