bluuebunny/crossref_metadata_2025_split huggingface dataset:
Near‐gapless genome assemblies of Williams 82 and Lee cultivars for accelerating global soybean research
Authors: Garg Vanika , Khan Aamir W. , Fengler Kevin , Llaca Victor , Yuan Yuxuan , Vuong Tri D. , Harris Charlotte , Chan Ting‐Fung , Lam Hon Ming , Varshney Rajeev K. , Nguyen Henry T. 
Published: September 2023

AbstractComplete, gapless telomere‐to‐telomere chromosome assemblies are a prerequisite for comprehensively investigating the architecture of complex regions, like centromeres or telomeres and removing uncertainties in the order, spacing, and orientation of genes. Using complementary genomics technologies and assembly algorithms, we developed highly contiguous, nearly gapless, genome assemblies for two economically important soybean [Glycine max (L.) Merr] cultivars (Williams 82 and Lee). The centromeres were distinctly annotated on all the chromosomes of both assemblies. We further found that the canonical telomeric repeats were present at the telomeres of all chromosomes of both Williams 82 and Lee genomes. A total of 10 chromosomes in Williams 82 and eight in Lee were entirely reconstructed in single contigs without any gap. Using the combination of ab initio prediction, protein homology, and transcriptome evidence, we identified 58,287 and 56,725 protein‐coding genes in Williams 82 and Lee, respectively. The genome assemblies and annotations will serve as a valuable resource for studying soybean genomics and genetics and accelerating soybean improvement.
Genomic selection of soybean (Glycine max) for genetic improvement of yield and seed composition in a breeding context
Authors: Miller Mark J. , Song Qijian , Li Zenglu 
Published: September 2023

AbstractGenomic selection has been utilized for genetic improvement in both plant and animal breeding and is a favorable technique for quantitative trait development. Within this study, genomic selection was evaluated within a breeding program, using novel validation methods in addition to plant materials and data from a commercial soybean (Glycine max) breeding program. A total of 1501 inbred lines were used to test multiple genomic selection models for multiple traits. Validation included cross‐validation, inter‐environment, and empirical validation. The results indicated that the extended genomic best linear unbiased prediction (EGBLUP) model was the most effective model tested for yield, protein, and oil in cross‐validation with accuracies of 0.50, 0.68, and 0.64, respectively. Increasing marker number from 1000 to 3000 to 6000 single nucleotide polymorphism markers leads to statistically significant increases in accuracy. Cross‐environment predictions were statistically lower than cross‐validation with accuracies of 0.24, 0.54, and 0.42 for yield, protein, and oil, respectively, using the extended genomic BLUP model. Empirical validation, predicting the yield of 510 soybean lines, had a prediction accuracy of 0.34, with the inclusion of a maturity covariate leading to a notable increase in accuracy. Genomic selection identified high‐performance lines in inter‐environment predictions: 34% of lines within the upper quartile of yield, and 51% and 48% of the highest quartile protein and oil lines, respectively. Statistically similar results occurred comparing rankings in empirical validation and selection for advancements in yield trials. These results indicate that genomic selection is a useful tool for selection decisions.
Warding off freshwater salinization: Do current criteria measure up?
Authors: Kelly Martyn G. , Free Gary , Kolada Agnieszka , Phillips Geoff , Warner Stuart , Wolfram Georg , Poikane Sandra 
Published: September 2023

AbstractSalinization is a global threat to freshwater habitats that has been intensified by climate change. Monitoring, assessment and management of salinity is therefore essential. The first step is to set criteria that are sufficiently stringent to protect ecosystem health. However, many countries have not yet defined criteria, and there are substantial differences between criteria. This has been noted in the EU, where salinity is a required “supporting element” for ecological status in inland waters but also for implementation of UN Sustainable Development Goal (SDG) indicator 6.3.2. for “good ambient water quality” where different approaches and widely different threshold values were reported for salinity criteria. Much of this information has not been published and is difficult to access, hindering further efforts to address the problem. We first discuss the implications of salinization for freshwater ecological health. We go on to discuss the principles and guidelines on how salinity criteria to protect ecology should be established. Next, we review salinity criteria submitted as part of implementation of SDG indicator 6.3.2 and the EU Water Framework Directive. Finally, we discuss setting salinity thresholds in an already‐warming world and the challenges facing anyone trying to develop salinity criteria to protect freshwater ecosystems.This article is categorized under:
Water and Life > Stresses and Pressures on Ecosystems
Water and Life > Conservation, Management, and Awareness
Science of Water > Water Quality
Authoritarian Clientelism: The Case of the President’s ‘Creatures’ in Cameroon
Authors: Mişcoiu Sergiu , Kakdeu Louis‑Marie 
Published: September 2023

AbstractWithin this article, we aim at exploring the topic of clientelism in Cameroon as a species of a wider phenomenon affecting Central and Western Francophone Africa. Our argument is that, in spite of the repeated efforts of reinforcing the local power structures, we have witnessed a process of centralisation of clientelism: the new networks are shaped around the ‘Creatures’, who are the President Paul Biya’s formal or informal appointees and play the role of nodal elements relying the rest of the chain to the central command. This happened on the expenses of the locally dispersed and more autonomous clientelistic groups that were either included in or smashed by the pyramidal Creatures’ structured. In order to test our assumption, we analysed a specific body of literature on the theorization of clientelism and on its African and Cameroonian specificity and organized four focus groups with the actual and former members of the clientelistic chains at different levels (central, regional and local). If our main presupposition proved to be generally correct, one of the sub-arguments was only partially validated through this empirical component of our research.
Coordinating the Machine: Subnational Political Context and the Effectiveness of Machine Politics
Authors: Saikkonen Inga A.‑L. 
Published: September 2023

AbstractPolitical machines use state resources to win elections in many developing democracies and electoral autocracies. Recent research has noted that the coordination of machine politics can be much more complex and problem-prone than previously thought. Yet, the role that the subnational political context plays in solving these coordination problems has largely been neglected in the comparative literature. This article seeks to fill this gap and suggests that control over the local administration is an important variable that shapes the effectiveness of authoritarian machine politics. We exploit the great institutional and political variation within one of the most prominent electoral authoritarian regimes of today, the Russian Federation, to test the empirical implications of the theory with detailed local level electoral and socio-economic data as well as multilevel regression models. The empirical results highlight the importance of subnational political structures in supporting electoral authoritarian regimes.
Isometries and the double copy
Authors: Easson Damien A. , Herczeg Gabriel , Manton Tucker , Pezzelle Max 
Published: September 2023

Abstract
In the standard derivation of the Kerr-Schild double copy, the geodicity of the Kerr-Schild vector and the stationarity of the spacetime are presented as assumptions that are necessary for the single copy to satisfy Maxwell’s equations. However, it is well known that the vacuum Einstein equations imply that the Kerr-Schild vector is geodesic and shear-free, and that the spacetime possesses a distinguished vector field that is simultaneously a Killing vector of the full spacetime and the flat background, but need not be timelike with respect to the background metric. We show that the gauge field obtained by contracting this distinguished Killing vector with the Kerr-Schild graviton solves the vacuum Maxwell equations, and that this definition of the Kerr-Schild double copy implies the Weyl double copy when the spacetime is Petrov type D. When the Killing vector is taken to be timelike with respect to the background metric, we recover the familiar Kerr-Schild double copy, but the prescription is well defined for any vacuum Kerr-Schild spacetime and we present new examples where the Killing vector is null or spacelike. While most examples of physical interest are type D, vacuum Kerr-Schild spacetimes are generically of Petrov type II. We present a straightforward example of such a spacetime and study its double copy structure. Our results apply to real Lorentzian spacetimes as well as complex spacetimes and real spacetimes with Kleinian signature, and provide a simple correspondence between real and self-dual vacuum Kerr-Schild spacetimes. This correspondence allows us to study the double copy structure of a self-dual analog of the Kerr spacetime. We provide evidence that this spacetime may be diffeomorphic to the self-dual Taub-NUT solution.
Principles of oncology taught in a one-week course
Authors: Oettle Matthias , Büttner Marcel , Forster Marie , Gajdi Laura , Mücke Johannes , Nieto Alexander , Heuser Sonja , Huber Johanna , Walter Franziska , Corradini Stefanie , Niyazi Maximilian , Belka Claus , Dreyling Martin , Fischer Martin R. , Fleischmann Daniel F. 
Published: September 2023

Abstract
Background
Growing challenges in oncology require evolving educational methods and content. International efforts to reform oncology education are underway. Hands-on, interdisciplinary, and compact course formats have shown great effectiveness in the education of medical students. Our aim was to establish a new interdisciplinary one-week course on the principles of oncology using state-of-the-art teaching methods.

Methods
In an initial survey, medical students of LMU Munich were questioned about their current level of knowledge on the principles of oncology. In a second two-stage survey, the increase in knowledge resulting from our recently established interdisciplinary one-week course was determined.

Results
The medical students’ knowledge of clinically important oncological topics, such as the diagnostic workup and interdisciplinary treatment options, showed a need for improvement. Knowledge of the major oncological entities was also in an expandable state. By attending the one-week course on the principles of oncology, students improved their expertise in all areas of the clinical workup in oncology and had the opportunity to close previous knowledge gaps. In addition, students were able to gain more in-depth clinical knowledge on the most common oncological entities.

Conclusion
The interdisciplinary one-week course on the principles of oncology proved to be an effective teaching method to expand the knowledge of the future physicians to an appropriate level. With its innovative and interdisciplinary approach, the one-week course could be used as a showcase project for the ongoing development of medical education in Germany.
Wild boar (Sus scrofa) as a potential reservoir of infectious agents in Portugal: a review of two decades (2001–2021)
Authors: Jota Baptista Catarina , Seixas Fernanda , Gonzalo-Orden José M. , Oliveira Paula A. 
Published: September 2023

AbstractThe wild boar (Sus scrofa) is a mammal with a broad distribution in the Eurasian territory and a potential reservoir for several zoonotic pathogens. Besides being part of the Mediterranean ecosystem and perpetuating these agents in the environment, this species is usually consumed in the Iberian Peninsula, representing a potential public health threat. Due to its extensive expansion and colonization of new geographical areas, which leads to increasing contact with humans, domestic animals, and wildlife, infectious disease assessments are crucial. During the last two decades (2001–2021), several researchers have studied wild boars to identify, understand, and predict potential health risks and disease outbreaks in animals and humans. North-eastern, central-eastern (mainly because of tuberculosis), and southern Portugal were the regions where most pathogens have been identified. Some agents with zoonotic importance (but with few reported data) should be the focus of future surveillance studies, such as Leptospira spp., Brucella spp., or Trichinella spp. This review aims to summarize the available information on pathogens (bacteria, viruses, and parasites) reported in wild boars, in Portugal, in the last two decades, with a particular focus on agents with zoonotic potential.
The Quarantine Model and its Limits
Authors: Lavazza Andrea , Levin Sergei , Farina Mirko 
Published: September 2023

AbstractThere are several well-established theories of criminal punishment and of its justification. The quarantine model (advocated by Pereboom and Caruso) has recently emerged as one of the most prominent theories in the field, by denying the very idea of criminal justice. This theory claims that no one ought to be criminally punished because fundamentally people do not deserve any kind of punishment. On these grounds, the quarantine model proposes forms of incapacitation based on public safety considerations. In this article, we briefly review a series of objections raised against the quarantine model and propose some new or revised arguments, which are aimed at showing its inconsistencies and weaknesses. These arguments are related to (a) the lack of a reliable way of determining who is dangerous and the consequent need to make judgments about confinement based on probabilities, and (b) the prospect that the quarantine model may encourage certain crimes. Given the arguments we present in this paper, the quarantine model proves to be less solid, humane, and desirable than its proponents claim.
How multiple levels of metacognitive awareness operate in collaborative problem solving
Authors: Çini Ahsen , Järvelä Sanna , Dindar Muhterem , Malmberg Jonna 
Published: September 2023

AbstractMetacognitive awareness is knowing about learners’ own thinking and learning, facilitated by introspection and self-evaluation. Although metacognitive functions are personal, they cannot be explained simply by individual conceptions, especially in a collaborative group learning context. This study considers metacognitive awareness on multiple levels. It investigates how metacognitive awareness at the individual, social, and environmental levels are associated with collaborative problem solving (CPS). Seventy-seven higher education students collaborated in triads on a computer-based simulation about running a fictional company for 12 simulated months. The individual level of metacognitive awareness was measured using the Metacognitive Awareness Inventory. The social level of metacognitive awareness was measured multiple times during CPS through situated self-reports, that is, metacognitive judgements and task difficulty. The environmental level of metacognitive awareness was measured via a complex CPS process so that group members’ interactions were video recorded and facial expression data were created by post-processing video-recorded data. Perceived individual and group performance were measured with self-reports at the end of the CPS task. In the analysis, structural equation modelling was conducted to observe the relationships between multiple levels of metacognitive awareness and CPS task performance. Three-level multilevel modelling was also used to understand the effect of environmental-level metacognitive awareness. The results reveal that facial expression recognition makes metacognitive awareness visible in a collaborative context. This study contributes to research on metacognition by displaying both the relatively static and dynamic aspects of metacognitive awareness in CPS.
Electric powered wheelchair control using user-independent classification methods based on surface electromyography signals
Authors: Iqbal Hassam , Zheng Jinchuan , Chai Rifai , Chandrasekaran Sivachandran 
Published: September 2023

AbstractWheelchairs are one of the most popular assistive technology (AT) among individuals with motor impairments due to their comfort and mobility. People with finger problems may find it difficult to operate wheelchairs using the conventional joystick control method. Therefore, in this research study, a hand gesture-based control method is developed for operating an electric-powered wheelchair (EPW). This study selected a comfort-based hand position to determine the stop maneuver. An additional exploration was undertaken to investigate four gesture recognition methods: linear regression (LR), regularized linear regression (RLR), decision tree (DT), and multi-class support vector machine (MC-SVM). The first two methods, LR and RLR, have promising accuracy values of 94.85% and 95.88%, respectively, but each new user must be trained. To overcome this limitation, this study explored two user-independent classification methods: MC-SVM and DT. These methods effectively addressed the finger dependency issue and demonstrated remarkable success in recognizing gestures across different users. MC-SVM has about 99.05% of both precision and accuracy, and the DT has about 97.77% accuracy and precision. All six participants were successful in controlling the EPW without any collisions. According to the experimental results, the proposed approach has high accuracy and can address finger dependency issues.
Thoughts on Integrating Evolutionary Analysis into Sociological Action Theory
Authors: Tutić Andreas 
Published: September 2023

AbstractIt is explored if and to what extent two approaches in behavioral sciences, which are promising with respect to an evolutionary grounded, integrative action theory, are actually compatible. These two approaches are, on the one hand, evolutionary psychology, which conceptualizes human nature as a collection of evolved psychological mechanisms, each being functionally specialized with respect to a specific problem of adaptation. And on the other hand, the dual-process perspective, which holds that human behavior is driven by the interplay of two qualitatively distinct types of cognitive processes: Autonomous, fast, and associative Type 1 processes, which operate outside of the consciousness of the actor, on the one hand, and controlled, slow, and rule-based Type 2 processes of which the actor is aware. Notably, both of these approaches have descendants in modern sociological action theory, i.e., goal-framing theory (Lindenberg 2008, 2009) and the model of frame-selection (Esser 2001; Kroneberg 2011). It is argued that evolutionary psychology and the dual-process perspective are largely compatible, thereby giving rise to an evolutionary grounded, integrative action theory. Accordingly, Type 1 processes can be traced back to evolutionary old cognitive modules, which humans share with other species and which are highly efficient at solving specific problems of adaptation in a stable environment. In contrast, Type 2 processes of higher cognition are distinctly developed in humans and highly effective at dealing with a rapidly changing life space.
Feasibility and efficacy of ‘Can-Sleep’: effects of a stepped-care approach to cognitive-behavioral therapy for insomnia in cancer
Authors: Diggens Justine , Bullen Dani , Maccora Jordan , Wiley Joshua F. , Ellen Steve , Goldin Jeremy , Jefford Michael , Hickey Martha , Ftanou Maria 
Published: September 2023

Abstract

Purpose
This study aimed to evaluate the feasibility and clinical efficacy of the Can-Sleep stepped-care intervention for people with cancer-related sleep disturbance.

Methods
A total of 147 individuals with cancer were screened. Participants who reported sleep disturbances and were at low-moderate risk for intrinsic sleep abnormalities were given self-managed cognitive behavioral therapy for insomnia (SMCBT-I). Those reporting sleep disturbance and scoring at high risk of intrinsic sleep abnormalities (i.e., restless leg syndrome and obstructive sleep apnoea) were referred to a specialist sleep clinic. In both groups, participants received a stepped-up group CBT-I intervention (GCBT-I) if they continued to report sleep disturbance following SMCBT-I or the specialist sleep clinic.

Results
Overall, 87 participants reported sleep disturbance or screened at risk for intrinsic sleep abnormality. Thirty-four were referred to a specialist sleep clinic, and of the 17 who declined this referral, 14 were rereferred to SMCBT-I. In total, 62 participants were referred to SMCBT-I, and 56 commenced SMCBT-I. At post-intervention, the SMCBT-I group showed a significant decline in insomnia symptoms (p < .001, d = 1.01). Five participants who reported sleep disturbance after SMCBT-I and/or the specialist sleep clinic, accepted GCBT-I. Those who received the GCBT-I showed a significant reduction in insomnia symptoms (p < .01, d = 3.13).

Conclusions
This study demonstrates the feasibility and efficacy of a stepped-care intervention for sleep disturbances in people with cancer.

Implications for cancer survivors
A stepped-care intervention for sleep disturbance is a feasible and potentially effective method of addressing a significant and unmet patient need.
Subcutaneous adipose tissue dopamine D2 receptor is increased in prediabetes and T2D
Authors: Vranic Milica , Ahmed Fozia , Kristófi Robin , Hetty Susanne , Mokhtari Dariush , Svensson Maria K. , Eriksson Jan W. , Pereira Maria J. 
Published: September 2023

Abstract
Purpose
To evaluate the dopaminergic signaling in human adipose tissue in the context of obesity and type 2 diabetes (T2D) and potential direct implications in adipose tissue metabolism.

Methods
mRNA and protein expression of dopamine receptors D1 and D2 (DRD1 and DRD2) were determined in subcutaneous adipose tissue from subjects without or with T2D and with different body weight, and correlated with markers of obesity, hyperglycemia, and insulin resistance. Glucose uptake and lipolysis were measured in adipocytes ex vivo following short-term exposure to dopamine, DRD1 receptor agonist (SKF81297), or DRD2 receptor agonist (bromocriptine).

Results
DRD1 and DRD2 gene expression in subcutaneous adipose tissue correlated positively with clinical markers of insulin resistance (e.g. HOMA-IR, insulin, and triglycerides) and central obesity in subjects without T2D. Protein expression of DRD2 in subcutaneous adipose tissue, but not DRD1, is higher in subjects with impaired fasting glucose and T2D and correlated positively with hyperglycemia, HbA1c, and glucose AUC, independent of obesity status. DRD1 and DRD2 proteins were mainly expressed in adipocytes, compared to stromal vascular cells. Dopamine and dopaminergic agonists did not affect adipocyte glucose uptake ex vivo, but DRD1 and DRD2 agonist treatment inhibited isoproterenol-stimulated lipolysis.

Conclusion
The results suggest that protein expression of DRD2 in subcutaneous adipose tissue is up-regulated with hyperglycemia and T2D. Whether DRD2 protein levels contribute to T2D development or occur as a secondary compensatory mechanism needs further investigation. Additionally, dopamine receptor agonists inhibit adipocyte beta-adrenergic stimulation of lipolysis, which might contribute to the beneficial effects in lipid metabolism as observed in patients taking bromocriptine.