bluuebunny/crossref_metadata_2025_split huggingface dataset:
A signalling rheostat controls chromosome segregation fidelity during early lineage specification and neurogenesis by modulating DNA replication stress
Authors: De Jaime-Soguero A , Hattemer J , Haas A , Bufe A , Di Marco B , Böhly N , Landry JJM , Schoell B , Rosa VS , Villacorta L , Baskan Y , Androulaki S , Trapp M , Benes V , Das B , Shahbazi M , Jauch A , Engel U , Patrizi A , Sotillo R , Bageritz J , Alfonso J , Bastians H , Acebrón SP 
Published: July 2023

AbstractThe development and homeostasis of organisms rely on the correct replication, maintenance and segregation of their genetic blueprints. How these intracellular processes are monitored across generations of different human cellular lineages, and why the spatio-temporal distribution of mosaicism varies during development remain unknown. Here, we identify several lineage specification signals that regulate chromosome segregation fidelity in both human and mouse pluripotent stem cells. Through epistatic analyses, we find that that WNT, BMP and FGF form a signalling “rheostat” upstream of ATM that monitors replication fork velocity, origin firing and DNA damage during S-phase in pluripotency, which in turn controls spindle polymerisation dynamics and faithful chromosome segregation in the following mitosis. Cell signalling control of chromosome segregation fidelity declines together with ATM activity after pluripotency exit and specification into the three human germ layers, or further differentiation into meso– and endoderm lineages, but re-emerges during neuronal lineage specification. In particular, we reveal that a tug-of-war between FGF and WNT signalling in neural progenitor cells results in DNA damage and chromosome missegregation during cortical neurogenesis, which could provide a rationale for the high levels of mosaicism in the human brain. Our results highlight a moonlighting role of morphogens, patterning signals and growth factors in genome maintenance during pluripotency and lineage specification, which could have important implications for our understanding on how mutations and aneuploidy arise during human development and disease.One sentence summaryDevelopmental signals link genome maintenance to cell fate
The influence of skepticism on the university Millennials’ organic food product purchase intention
Authors: Hoyos-Vallejo Carlos Arturo , Carrión-Bósquez Nelson Geovany , Ortiz-Regalado Oscar 
Published: July 2023

Purpose This study extends the Theory of Planned Behavior (TPB) and analyzes the influence of skepticism (SKP) on the purchase intention (PI) of organic products, through the mediation of subjective norms (SN) and planned behavior control.Design/methodology/approach This was a quantitative, correlational and cross-sectional study. The study population comprised 446 university Millennials from Ecuador. Results were processed using exploratory factor analysis (EFA), confirmatory factor analysis (CFA) and structural equation modeling (SEM).Findings The study showed that SKP does not directly influence the PI. However, if it does so through the mediating effect of SN and perceived behavior control (PBC). Also, the study found that attitudes (ATTs), SN and PBC influence the PI of organic products in university Millennials.Originality/value The study used TPB constructs and identified the influence of SKP on the intention to buy organic products in Ecuadorian university Millennials.
A conceptual framework for practicing inclusive dialogic organization development in times of uncertainty and complexity
Authors: Kwon Chang-kyu , Kwon Kibum 
Published: July 2023

Purpose
The purpose of this paper is to propose a conceptual framework for practicing inclusive dialogic organization development (OD).

Design/methodology/approach
This paper reviews and presents Robert Kegan’s theory and practice of deliberately developmental organization as an exemplary model for dialogic OD.

Findings
The paper suggests three conditions to make the constantly emerging organizational reality socially just, equitable and inclusive – whole self, psychological safety and leader vulnerability.

Originality/value
The originality of this paper lies in making explicit issues of power in dialogic OD literature and providing implications for human resource development on how to lead and develop organizations inclusively in times of uncertainty and complexity.
BIM implementation model from the standpoint of concern-based adoption theory
Authors: Olugboyega Oluseye , Elubode Itunnu Dorcas , Oseghale Godwin Ehis , Aigbavboa Clinton 
Published: July 2023

PurposeThis study investigated the concerns and plans of construction professionals about building information modeling (BIM) implementation, found the acceptable BIM implementation driving forces and strategies for them and developed a prescriptive BIM implementation model to help understand how BIM implementation concerns, intentions, driving forces and strategies are connected.Design/methodology/approachThis study employs a positivist paradigm with a hypothetico-deductive research strategy as well as concern-based adoption theory as a conceptual lens to distinguish construction professionals (CPs)' BIM implementation concerns and intentions. This implies that the forces driving BIM implementation intentions and concerns are related to BIM implementation methods and that their concentrations are proportional to the intensity of BIM implementation strategies. A 16-item questionnaire tailored to the operations of CPs was used for data collection. The data collected from respondents were utilized to evaluate the proposed model using structural equation modeling (SEM) techniques.FindingsFindings from the data collected from the respondents revealed that CPs are concerned about the impact of BIM deployment on their time and service quality. Their main purpose was to take drives to learn more about BIM in order to pique their curiosity. Embracing the latest digital technology and beginning self-initiated BIM training are two strategies that would be quite effective in boosting BIM deployment.Research limitations/implicationsThe study identifies promising directions for future BIM implementation research and development. The study's findings imply that more theoretically motivated research, rather than just empirical research, is required to refine BIM implementation concerns.Practical implicationsThe study has implications for the professional development of CPs as well as understanding the process of implementing BIM change. The study's findings will help to understand the resource system for assessing CPs' needs and concerns and selecting personalized BIM implementation strategies.Originality/valueBefore this study, BIM-related studies had ignored the concerns and goals of the CPs when it came to implementing BIM. Using the CPs' concerns and hopes for BIM implementation, a systemic BIM implementation model was developed that would help and speed up BIM adoption.
Distributional impacts of anchor borrower program on the welfare of rice farming households in Oyo State, Nigeria
Authors: Emokpae Osayi Precious , Emokaro Christopher Osamudiamen , Umeokeke Nneji Ifeyinwa 
Published: July 2023

PurposeThis study assessed the heterogeneous impact of the Anchor Borrower Program (ABP) on the welfare distribution of rice farming households in Nigeria.Design/methodology/approachSelf-selection bias and treatment endogeneity were accounted for by employing the Instrumental Variable Quantile Regression (IVQR) model. The estimates obtained from the IVQR model were further compared with those from the conventional quantile regression, and quantile regression using Propensity Score Matching. This was to highlight the extent to which endogeneity bias has been purged from the treatment, in order to establish a consistent causal link between participation in the ABP and the welfare of a cross-section of rice farming households.FindingsABP farmers had significantly higher rice yields across all quantiles of the yield distribution under treatment exogeneity assumption, and in only two quantiles upon controlling for observable confounders. However, this yield gain did not translate to higher Per capita Consumption Expenditure (PCE). The estimates of the more robust IVQR model provided further evidence that the rice yield and PCE of ABP farmers are not statistically different from that of non-ABP farmers across all quantiles of the welfare distribution.Social implicationsThe negligible impact of ABP was relatively higher for lower-yielding households. Thus, implying that, although the ABP is a pro-poor development intervention, the program has not been sufficiently implemented to significantly improve the welfare of the dominant resource-poor farming households in Nigeria.Originality/valueThis study assessed the impact of ABP beyond the conventional potential mean outcome framework by accounting for heterogeneity in treatment effect.Peer reviewThe peer review history for this article is available at: https://publons.com/publon/10.1108/IJSE-02-2023-0083
Liquidity, informational efficiency and firm default risk: a systematic literature review
Authors: Zhao Lingling , Mollica Vito , Shen Yun , Liang Qi 
Published: July 2023

Purpose This study aims to systematically review the literature in the fields of liquidity, informational efficiency and default risk. The authors outline the key research streams and provide possible pathways for future research.Design/methodology/approach The study adopts bibliographic mapping to identify the most influential studies in the research fields of liquidity, informational efficiency and default risk from 1984 to 2021.Findings The study identifies four key research themes that include efficiency and transparency of markets; corporate yield spreads; market interactions: bonds, stocks and cryptocurrencies; and corporate governance. By assessing publications published from 2018 to 2021, the authors also document seven key emerging research trends: cross markets, managerial learning and corporate governance, state ownership and government subsidies, international evidence, machine learning (FinTech approaches), environmental themes and financial crisis. Drawing on these emerging trends, the authors highlight the opportunities for future research.Research limitations/implications Keyword searches have limitations since some studies might be overlooked if they do not match the specified search criteria, even though their relevance to the topic is under investigation. Adopt the R project to expand this review by incorporating more literature from other databases, such as the Scopus database could be a possible solution.Practical implications The four key research streams contribute to a comprehensive understanding of liquidity, informational efficiency and default risk. The emerging trends integrate existing knowledge and leave the chance for innovative research to expand the research frontier.Originality/value This study fulfills the systematic literature review streams in the fields of liquidity, informational efficiency and default risk, and provides fruitful opportunities for future research.
A hybrid model of implementing a smart production factory within the Industry 4.0 framework
Authors: Samani Armin , Saghafi Fatemeh 
Published: July 2023

Purpose
This study aims to introduce the model of implementation to run the smart production factories. The study also aims to investigate the Industry 4.0 technologies as enablers to deal with challenges in the way of implementation.

Design/methodology/approach
This contribution benefits from two teams of experts to evaluate the challenges and technologies of Industry 4.0. The Hanlon method is applied to evaluate, rank and prioritise the challenges which are initially scored by experts’ Team 1. Then, the adjacency matrix among enablers and challenges is extracted through the opinions of experts’ Team 2. The study also uses fuzzy cognitive map (FCM) to evaluate the real weights of technologies and challenges, rank and prioritise subsequently.

Findings
A total of 8 challenging obstacles and 24 key technologies have been evaluated. The findings reveals that recruit and retention of experienced managers, undefined return on investment and recruit and retention of multi-skilled workers are the most serious challenges in the way of implementing smart production factories. Furthermore, big data, IT-based management and Internet of Things are the top-ranked key enablers to face the challenges.

Originality/value
To the best of the authors’ knowledge, this study is one of the pioneering studies that uses Hanlon method to evaluate industrial challenges. Integrating Hanlon method and FCM leads to a comprehensive model of evaluation and ranking which is another novelty of this contribution. Although many research studies have been released to implement the smart factories, practical model of implementation for production factories is identified as a literature gap.
Mapping the incidence of drug‐induced liver injury: A systematic review and meta‐analysis
Authors: Li Min , Wang Yu , Lv Ting Ting , Liu Ji Min , Kong Yuan Yuan , Jia Ji Dong , Zhao Xin Yan 
Published: July 2023

ObjectivesDrug‐induced liver injury (DILI) is an increasing etiology of liver dysfunction, with various incidence worldwide. To better understand the disease burden and establish appropriate preventive and treatment strategies, a systematic review and meta‐analysis was conducted.MethodsPubMed, EMBASE, Web of Science, and Cochrane Library were searched for studies on the incidence of DILI published up to June 1, 2022. According to the predefined criteria, only population‐based studies were included. Incidence was presented as cases per 100 000 person‐years with 95% confidence interval (CI) using a random‐effects model.ResultsA total of 14 studies were included. The overall incidence of DILI was 4.94 per 100 000 person‐years (95% CI 4.05–5.83). Time‐based cumulative meta‐analysis suggested that the incidence of DILI increased over time since 2010. The incidence varied by regions, with Asia having the highest incidence of 17.82 per 100 000 person‐years (95% CI 6.26–29.38), while North America having the lowest incidence of 1.72 per 100 000 person‐years (95% CI 0.48–2.95). All studies reported a higher incidence of DILI in the elderly but comparable incidences between male and female (3.42 per 100 000 person‐years vs 4.64 per 100 000 person‐years).ConclusionsThe global incidence of DILI has been increasing since 2010, with the highest incidence in Asia. Understanding the epidemiological characteristics of DILI helps establish specific strategies to deal with this emerging health problems.
Phase II study of neoadjuvant chemotherapy with four cycles of dose‐dense MVAC followed by radical cystectomy in Korean patients with muscle‐invasive or locally advanced urothelial carcinoma of bladder
Authors: Park Kwonoh , Lee Hyun Jung , Kim Tae Un , Ryu Hwaseong , Ki Yong Kan , Hong Yun Jeong , Nam Jong Kil 
Published: July 2023

AbstractPurposeWhile previous retrospective or phase II studies in Western populations showed that dose‐dense methotrexate, vinblastine, doxorubicin, and cisplatin (ddMVAC) as neoadjuvant chemotherapy (NAC) was beneficial, no studies have been reported in Asian populations. This prospective phase II study aimed to evaluate efficacy and safety of ddMVAC in Korean patients with muscle‐invasive bladder cancer (MIBC) or locally advanced urothelial cancer (UC).Materials and MethodsPatients with MIBC (cT2–4aN0M0) or locally advanced UC (cTanyN1–3M0) eligible for radical cystectomy (RC) were enrolled prospectively. The participants were treated with four cycles of ddMVAC with pegfilgrastim every 2 weeks. The primary endpoint was pathologic response rate (≤ypT1N0). Secondary endpoints were pathologic complete response (pCR, ypT0N0), relapse‐free survival (RFS), overall survival (OS), and safety.ResultsAmong 24 patients enrolled between December 2019 and August 2021, 23 were evaluable (52%, cT2–4aN0; 48%, cTanyN1–3). Eighteen patients (78%) completed four cycles of ddMVAC, while remaining five patients experienced early discontinuation. Dose modification (91%) and dose delay (70%) occurred, and the dose intensity of ddMVAC was 79%. Nineteen patients underwent RC and four patients declined. Of 19 patients who underwent RC, eight patients (42%) achieved ≤ypT1N0. With a median follow‐up of 22.8 months, the median RFS was 13.5 months (95% CI, not yet evaluable) and the median OS was 28.9 months (95% confidence interval, 19.9–37.9).ConclusionOur study showed substantial efficacy and safety of ddMVAC, even in patients with locally advanced UC. The ddMVAC still should be a promising option as NAC in Asian patients with UC.
Decreased DHA‐containing phospholipids in the neocortex of dementia with Lewy bodies are associated with soluble Aβ42, phosphorylated α‐synuclein, and synaptopathology
Authors: Chong Joyce R. , Chai Yuek Ling , Xing Huayang , Herr Deron R. , Wenk Markus R. , Francis Paul T. , Ballard Clive , Aarsland Dag , Silver David L. , Chen Christopher P. , Cazenave‐Gassiot Amaury , Lai Mitchell K. P. 
Published: July 2023

AbstractDocosahexaenoic acid (DHA) is an essential omega‐3 polyunsaturated fatty acid implicated in cognitive functions by promoting synaptic protein expression. While alterations of specific DHA‐containing phospholipids have been described in the neocortex of patients with Alzheimer's disease (AD), the status of these lipids in dementia with Lewy bodies (DLB), known to manifest aggregated α‐synuclein‐containing Lewy bodies together with variable amyloid pathology, is unclear. In this study, post‐mortem samples from the parietal cortex of 25 DLB patients and 17 age‐matched controls were processed for phospholipidomics analyses using a liquid chromatography–tandem mass spectrometry (LC–MS/MS) platform. After controlling for false discovery rate, six out of the 46 identified putative DHA‐phospholipid species were significantly decreased in DLB, with only one showing increase. Altered putative DHA‐phospholipid species were subsequently validated with further LC–MS/MS measurements. Of the DHA‐containing phospholipid (DCP) species showing decreases, five negatively correlated with soluble beta‐amyloid (Aβ42) levels, whilst three also correlated with phosphorylated α‐synuclein (all p < 0.05). Furthermore, five of these phospholipid species correlated with deficits of presynaptic Rab3A, postsynaptic neurogranin, or both (all p < 0.05). Finally, we found altered immunoreactivities of brain lysolipid DHA transporter, MFSD2A, and the fatty acid binding protein FABP5 in DLB parietal cortex. In summary, we report alterations of specific DCP species in DLB, as well as their associations with markers of neuropathological burden and synaptopathology. These results support the potential role of DHA perturbations in DLB as well as therapeutic targets.
Floral nectar production: what cost to a plant?
Authors: Pyke Graham H. , Ren Zong‐Xin 
Published: July 2023

ABSTRACTFloral nectar production is central to plant pollination, and hence to human wellbeing. As floral nectar is essentially a solution in water of various sugars, it is likely a valuable plant resource, especially in terms of energy, with plants experiencing costs/trade‐offs associated with its production or absorption and adopting mechanisms to regulate nectar in flowers. Possible costs of nectar production may also influence the evolution of nectar volume, concentration and composition, of pollination syndromes involving floral nectar, and the production of some crops.There has been frequent agreement that costs of floral nectar production are significant, but relevant evidence is scant and difficult to interpret. Convincing direct evidence comes from experimental studies that relate either enhanced nectar sugar production (through repeated nectar removal) to reduced ability to produce seeds, or increased sugar availability (through absorption of additional artificial nectar) to increased seed production. Proportions of available photosynthate allocated by plants to nectar production may also indicate nectar cost. However, such studies are rare, some do not include treatments of all (or almost all) flowers per plant, and all lack quantitative cost–benefit comparisons for nectar production. Additional circumstantial evidence of nectar cost is difficult to interpret and largely equivocal.Future research should repeat direct experimental approaches that relate reduced or enhanced nectar sugar availability for a plant with consequent ability to produce seeds. To avoid confounding effects of inter‐flower resource transfer, each plant should experience a single treatment, with treatment of all or almost all flowers per plant. Resource allocation by plants, pathways used for resource transfer, and the locations of resource sources and sinks should also be investigated.Future research should also consider extension of nectar cost into other areas of biology. For example, evolutionary models of nectar production are rare but should be possible if plant fitness gains and costs associated with nectar production are expressed in the same currency, such as energy. It should then be possible to understand observed nectar production for different plant species and pollination syndromes involving floral nectar. In addition, potential economic benefits should be possible to assess if relationships between nectar production and crop value are evaluated.
Oral health‐related stigma: Describing and defining a ubiquitous phenomenon
Authors: Doughty J. , Macdonald M. E. , Muirhead V. , Freeman R. 
Published: July 2023

AbstractThis paper is the fourth of a series of narrative reviews to critically rethink underexplored concepts in oral health research. The series commenced with an initial commissioned framework of Inclusion Oral Health, which spawned further exploration into the social forces that undergird social exclusion and othering. The second review challenged unidimensional interpretations of the causes of inequality by bringing intersectionality theory to oral health. The third exposed how language, specifically labels, can perpetuate and (re)produce vulnerability by eclipsing the agency and power of vulnerabilised populations. In this fourth review, we revisit othering, depicted in the concept of stigma. We specifically define and conceptualize oral health‐related stigma, bringing together prior work on stigma to advance the robustness and utility of this theory for oral health research.
Collective memory, martyrdom monument, and Christian‐Muslim reconciliation in Seko, North Luwu, Indonesia
Authors: Rumbi Frans Paillin , Palari Yoel Brian , Rando Anugerah Agustus 
Published: July 2023

AbstractThis study explores the collective memory of the DI/TII (Darul Islam/The Indonesian Islamic Army) case between 1951 and 1965, the martyrdom monument, and Christian‐Muslim reconciliation in Seko, Nort Luwu, and South Sulawesi. The monument portrays the interaction between Christians and Muslims during times of conflict and pushes society to construct a better developed civilization. Data collection is conducted using a qualitative approach. We adopt a bottom‐up approach, conducting interviews with perpetrators, their descendants, and the monument's creator. The aims of this study were (a) to analyze the collective memory of the Seko people about the DI/TII incident, (b) to find out why Christians in Seko erected a monument to the martyrs, and (c) to seek reconciliation between Christians and Muslims in Seko. We argue that the Seko community's use of sallombengang‐‐a philosophy promoting harmony and peace despite diversity‐‐can deter Seko parties from pursuing confrontation between Christians and Muslims.