bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influence of temperature, ion type, and ionic strength on dynamic viscoelastic, steady‐state, and dilute‐solution behavior of Melissa officinalis seed gum
Authors: Jafari Zahra , Shirazinejad Alireza , Hashemi Seyed Mohammad Bagher , Fathi Morteza 
Published: May 2023

AbstractIn this study, the rheological properties of Melissa officinalis seed gum (MOSG) as a function of temperature (25, 35, 45, 55, and 65°C) and salt concentrations (10, 50, 100, and 200 ppm NaCl and CaCl2) were investigated. The power law and Herschel‐Bulkley models could describe the rheological behavior of gum dispersions. The results showed that the intrinsic viscosity of the samples significantly decreased with increasing temperature and salt concentration. Steady‐state analysis of the samples revealed a non‐Newtonian, shear‐thinning behavior at tested temperatures and concentrations. The apparent viscosity increased with increasing salt concentrations and decreasing temperature. The results obtained from the frequency sweep test showed that the loss modulus (G″) values were higher than storage modulus (G′) in the concentrations of 0.25% to 0.5%, but beyond these concentrations, G′ values were greater than G″. The elasticity and viscosity of the gum samples increased with increasing concentration. The results of this study confirmed that MOSG has good rheological properties and can be used in food and pharmaceutical systems.Practical ApplicationsThe rheological behavior is the most important functional property of natural colloids. This property is related to the capacity of hydrocolloids in improving viscosity and the formation of gel structure at low concentrations. The thickening property of hydrocolloids has a determinant role in consumer acceptance. Furthermore, the consumer acceptance of different food products such as fruit juices, sauces, ready jells, and desserts is mainly dependent on rheological behavior. Therefore, investigation of rheological properties of the new source of food hydrocolloids is interested in food industries.
Acute care utilization and its associated determinants among patients with substance‐related disorders: A worldwide systematic review and meta‐analysis
Authors: Armoon Bahram , Griffiths Mark D. , Mohammadi Rasool , Ahounbar Elaheh , Fleury Marie‐Josée 
Published: May 2023

AbstractIntroductionIdentifying determinants of emergency department (ED) use and hospitalization among patients with substance‐related disorders (SRDs) can improve health services to address unmet health needs.AimThe present study aimed to identify the prevalence rates of ED use and hospitalization, and their associated determinants among patients with SRDs.MethodsStudies in English published from January 1, 1995, to December 1, 2022, were searched on PubMed, Scopus, Cochrane Library, and Web of Science to identify primary studies.ResultsThe pooled prevalence rates of ED use and hospitalization among patients with SRDs were 36% and 41%, respectively. Patients with SRDs who were the most at risk of being both ED users and hospitalized were those (i) having medical insurance, (ii) having other drug and alcohol use disorders, (iii) having mental health disorders, and (iv) having chronic physical illnesses. A lower level of education increased the risk of ED use only.DiscussionTo decrease ED use and hospitalization, more comprehensive services may be offered to these vulnerable patients with diversified needs.Implications for PracticeChronic care integrating outreach interventions could be more provided for patients with SRDs after discharge from acute care units or hospitals.
Genomic recovery lags behind demographic recovery in bottlenecked populations of the Channel Island fox, Urocyon littoralis
Authors: Adams Nicole E. , Edmands Suzanne 
Published: May 2023

AbstractWith continued global change, recovery of species listed under the Endangered Species Act is increasingly challenging. One rare success was the recovery and delisting of the Channel Island fox (Urocyon littoralis) after 90%–99% population declines in the 1990s. While their demographic recovery was marked, less is known about their genetic recovery. To address genetic changes, we conducted the first multi‐individual and population‐level direct genetic comparison of samples collected before and after the recent bottlenecks. Using whole‐exome sequencing, we found that already genetically depauperate populations were further degraded by the 1990s declines and remain low, particularly on San Miguel and Santa Rosa Islands, which underwent the most severe bottlenecks. The two other islands that experienced recent bottlenecks (Santa Cruz, and Santa Catalina islands) showed mixed results based on multiple metrics of genetic diversity. Previous island fox genomics studies showed low genetic diversity before the declines and no change after the demographic recovery, thus this is the first study to show a decrease in genetic diversity over time in U. littoralis. Additionally, we found that divergence between populations consistently increased over time, complicating prospects for using inter‐island translocation as a conservation tool. The Santa Catalina subspecies is now federally listed as threatened, yet other de‐listed subspecies are still recovering genetic variation which may limit their ability to adapt to changing environmental conditions. This study further demonstrates that species conservation is more complex than population size and that some island fox populations are not yet ‘out of the woods’.
Genetic control of photoprotection and photosystem II operating efficiency in plants
Authors: Sahay Seema , Grzybowski Marcin , Schnable James C. , Głowacka Katarzyna 
Published: May 2023

Summary

Photoprotection against excess light via nonphotochemical quenching (NPQ) is indispensable for plant survival. However, slow NPQ relaxation under low light conditions can decrease yield of field‐grown crops up to 40%.

Using semi‐high‐throughput assay, we quantified the kinetics of NPQ and photosystem II operating efficiency (ΦPSII) in a replicated field trial of more than 700 maize (Zea mays) genotypes across 2 yr. Parametrized kinetics data were used to conduct genome‐wide association studies.

For six candidate genes involved in NPQ and ΦPSII kinetics in maize the loss of function alleles of orthologous genes in Arabidopsis (Arabidopsis thaliana) were characterized: two thioredoxin genes, and genes encoding a transporter in the chloroplast envelope, an initiator of chloroplast movement, a putative regulator of cell elongation and stomatal patterning, and a protein involved in plant energy homeostasis.

Since maize and Arabidopsis are distantly related, we propose that genes involved in photoprotection and PSII function are conserved across vascular plants. The genes and naturally occurring functional alleles identified here considerably expand the toolbox to achieving a sustainable increase in crop productivity.
Radiotherapy upregulated immune checkpoints contribute to the development of second primary OSCC
Authors: Wang Li , Wang Siyu , Zhang Jiayu , Peng Jianmin , Cheng Bin , Li Huan , Hu Qinchao 
Published: May 2023

AbstractObjectivesRadiation injury is common after radiotherapy for head and neck cancer. Radiotherapy can reshape the immune microenvironment and cause immunosuppression, including dysregulation of immune checkpoints (ICs). However, the relationship between oral ICs expression after radiation and the development of second primary tumors is unclear.MethodsClinical specimens of second primary oral squamous cell carcinoma after radiotherapy (s‐OSCC) and primary OSCC (p‐OSCC) were collected. The expression and prognostic value of PD‐1, VISTA, and TIM‐3 were analyzed using immunohistochemistry. To further clarify the relationship between radiation and ICs alteration, a rat model was constructed to explore the spatiotemporal changes of ICs in the oral mucosa after radiation.ResultsIn carcinoma tissue, the expression of TIM‐3 was higher in s‐OSCC than in p‐OSCC, while the expression of PD‐1 and VISTA was similar between the groups. In para‐carcinoma tissue, the expression of PD‐1, VISTA, and TIM‐3 was higher in s‐OSCC. High ICs expression was associated with poor survival. In the rat model, ICs were locally upregulated in the irradiated tongue. Moreover, there was a bystander effect, in which the ICs were also upregulated in the unirradiated site.ConclusionRadiation may upregulate ICs expression in oral mucosa and contribute to the development of s‐OSCC.
miR‐27a‐5p alleviates periodontal inflammation by targeting phosphatase and tensin homolog deleted on chromosome ten
Authors: Deng Li , Huo Peng‐cheng , Feng Mei‐ting , Wang Rui‐ling , Jing Rui , Luo Li‐jun 
Published: May 2023

AbstractIntroductionMicroRNAs (miRNAs), a type of non‐coding RNA, have been demonstrated to be essential posttranscriptional modulators in oral diseases and inflammatory responses. However, the specific role of miR‐27a‐5p in periodontitis requires further investigation. In this study, we used both cellular and animal models to determine how miR‐27a‐5p affects the pathogenesis of periodontitis and its associated biological functions.MethodsQuantitative real‐time polymerase chain reaction and western blotting were used to analyze the expression of cytokines, phosphatase and tensin homolog deleted on chromosome ten (PTEN), and miR‐27a‐5p transcription. Investigation of alveolar bone resorption and inflammation of the periodontium in ligature‐induced periodontitis in mice was performed using micro‐computed tomography (micro‐CT), hematoxylin‐eosin (HE) staining, and tartrate‐resistant acid phosphatase (TRAP) staining. The binding of miR‐27a‐5p and PTEN was predicted using the TargetScan database and experimentally confirmed using dual luciferase reporter gene assays.ResultsThe inflamed gingiva showed lower levels of miR‐27a‐5p. Macrophages from miR‐27a‐5p–/– mice produced much higher quantities of pro‐inflammatory cytokines owing to the stimulation of Porphyromonas gingivalis lipopolysaccharide, and miR‐27a‐5p–/– mice with ligature‐induced periodontitis also exhibited more severe alveolar bone resorption and damage to the periodontium. Target validation assays identified PTEN as a direct target of bona. Blocking PTEN expression partially reduced inflammation, both in vitro and in vivo.ConclusionsmiR‐27a‐5p alleviated the inflammatory response in periodontitis by targeting PTEN.
Hydrogen peroxide regulates the Osa‐miR156‐OsSPL2/OsTIFY11b module in rice
Authors: Tseng Bo‐Shun , Huang Cheng‐Chung , King Yu‐Chi , Wu Ming‐Tsung , Hsieh Chih‐Hung , Hsieh Kun‐Ting , Hsing Yue‐Ie , Jeng Shih‐Tong 
Published: May 2023

AbstractField‐grown rice (Oryza sativa L.), when exposed to various environmental stresses, produces high amounts of reactive oxygen species, such as H2O2. MicroRNAs (miRNAs) play crucial roles in plant stress responses. This study characterized the functions of H2O2‐regulated miRNAs in rice. Small RNA deep sequencing revealed that miR156 levels decreased following H2O2 treatment. Searches of the rice transcriptome and degradome databases indicated that OsSPL2 and OsTIFY11b are miR156‐target genes. Interactions between miR156 and OsSPL2 and OsTIFY11b were confirmed using transient expression assays through agroinfiltration. In addition, the levels of OsSPL2 and OsTIFY11b transcripts were lower in transgenic rice plants overexpressing miR156 than in wild‐type plants. The OsSPL2‐GFP and OsTIFY11b‐GFP proteins were localized to the nucleus. Yeast two‐hybrid and bimolecular fluorescence complementation assays indicated interactions between OsSPL2 and OsTIFY11b. Furthermore, OsTIFY11b interacted with OsMYC2 to regulate the expression of OsRBBI3‐3, which encodes a proteinase inhibitor. The results suggested that H2O2 accumulation in rice suppresses the expression of miR156, and induces the expression of its target genes, OsSPL2 and OsTIFY11b, whose proteins interact in the nucleus to regulate the expression of OsRBBI3‐3, which is involved in plant defense.
Recalibrating evolutionary debunking
Authors: Koon Justis 
Published: May 2023

AbstractEvolutionary debunking arguments purport to show that, if moral realism is true, all of our moral beliefs are unjustified. In this paper, I respond to two of the most enduring objections that have been raised against these arguments. The first objection claims that evolutionary debunking arguments are self‐undermining, because they cannot be formulated without invoking epistemic principles, and epistemic principles are just as vulnerable to debunking as our moral beliefs. I argue that this objection suffers from several defects, the most serious of which is that it has the unpalatable consequence that we should never revise our moral beliefs in response to evidence that our capacity for normative cognition is globally impaired. The second objection, which comes to us from Katia Vavova, claims that evolutionary debunking arguments are doomed to fail, because they attempt to show that our moral beliefs are unreliable without making any assumptions about the nature of morality, and this is impossible. I argue, to the contrary, that the etiological higher‐order evidence cited by debunking arguments can give us good reason to think that our moral beliefs are unreliable, even if we make no assumptions about what morality is like.
Two sorts of biological kind terms: The cases of ‘rice’ and ‘Rio de Janeiro Myrtle’
Authors: Devitt Michael , Porter Brian 
Published: May 2023

AbstractExperiments have led some philosophers to conclude that the reference determination of natural kind terms is neither simply descriptive nor simply causal‐historical. Various theories have been aired to account for this, including ambiguity, hybrid, and different‐idiolects theories. Devitt and Porter (2021) hypothesized that some terms are covered by one theory, some another, with a place for all the proposed theories. The present paper tests hypotheses that the term ‘Rio de Janeiro Myrtle’ is simply causal‐historical but the term ‘rice’ is hybrid. For, whereas the former term is of scientific but little practical interest, the latter is not: rice is a significant part of the human diet. So, we predicted there would be two factors to the reference determination of ‘rice’: a superficial‐descriptive one and a deep‐causal one. Our experiments confirmed these hypotheses using the methods of elicited production and truth value judgments. We take our results to support the hybrid Theory of ‘rice’ rather than the ambiguity or different‐idiolects theory. We were not testing ‘myrtle’ but, surprisingly, our results implied that ‘myrtle’ was partly descriptive and so like ‘rice’ but not ‘Rio de Janeiro Myrtle’. A follow‐up experiment confirmed these puzzling results. More investigation is needed.
Risk justice: Boosting the contribution of risk management to sustainable development
Authors: de Goër de Herve Mathilde , Schinko Thomas , Handmer John 
Published: May 2023

AbstractComprehensively addressing different aspects of justice is essential to enable risk management to contribute to sustainable development. This article offers a new conceptual framework called risk justice that comprises procedural, distributive, and corrective justice in four dimensions related to sustainable development: social, ecological, spatial, and temporal issues. Risk justice is defined as the quality of being fair and reasonable while governing and managing a possible negative event. After explaining the conceptual framework, a detailed content analysis of two international guidelines for disaster risk management (the Sendai Framework for Disaster Risk Reduction 2015–2030 and the European Floods Directive) illustrates the analytical potential of the risk justice framework. Findings show strong emphasis on social and spatial aspects of distributive and procedural justice in the two documents, whereas considerations of corrective justice and temporal and ecological issues are scarce or indirect. This may result in conflicting impacts of disaster risk management on sustainable development. Therefore, discussing risk management with a risk justice viewpoint while elaborating guidelines or choosing risk management strategies provides new avenues for sustainable development and facilitates transparent trade‐offs. Our risk justice framework enables risk practitioners and researchers to reflect systemically about justice in risk management in different risk contexts and can be used both as a proactive and as a retrospective tool.
The lived experiences of endometriosis in adolescence—A critical hermeneutic perspective
Authors: Nielsen Liv Juul , Poulsen Katja , Funch Anders Lundme , Petersen Kirsten Schultz 
Published: May 2023

AbstractBackgroundEndometriosis is a condition that worldwide affects 10% of all women of childbearing age. Despite the large prevalence, it takes 4–11 years from the first onset of symptoms until the time of diagnosis, and the majority experience symptoms debut in adolescence. Endometriosis affects women's lives both physically, psychologically, socially and a lack of recognition from society causes the pain the women experience to be neglected, hidden and normalised. Preventative measures targeting endometriosis in adolescence are limited and there is a need to change the way these symptoms are viewed and affected by society at large.AimThe aim of this qualitative study was to explore the lived experiences of endometriosis in adolescence and the social reactions impact on the illness experience and quality of life.MethodWith a critical hermeneutic approach, individual interviews were conducted with women diagnosed with endometriosis. The analysis and interpretation were conducted inspired by Pedersen and Dreyer's (2018) method which is based on Ricoeur's critical theory.ResultsThe structural analysis shows that women experience a struggle for recognition of symptoms from their immediate surroundings including family, friends, schools and health professionals, as symptoms considered linked to menstruation are deemed to be normal for women to experience. The women's narratives are characterised into a before and after diagnosis. Therefore, the diagnosis is found to be important for the meaning that the women attach to their experiences in adolescence.ConclusionSocial experiences have a substantial impact on women's illness experience and quality of life and affect how women perceive themselves and their symptoms. Through interventions at the social level, it might be possible to change the existing societal discourses surrounding women's menstruation pain to raise the awareness of endometriosis.
Effect of the FIFA 11+ injury prevention program in collegiate female football players over three consecutive seasons
Authors: Magoshi Hirohisa , Hoshiba Takuma , Tohyama Miwako , Hirose Norikazu , Fukubayashi Toru 
Published: May 2023

AbstractThis study aimed to investigate the preventive effects of the FIFA 11+ for one‐season and over three consecutive seasons on the injury incidence rates in collegiate female football players in terms of duration of intervention. A total of 763 collegiate female football players from seven teams belonging to Kanto University Women Football Association Division 1 in 2013–2015 seasons were included in the study. At the start of the study, 235 players were assigned to a FIFA 11+ intervention group (four teams, 115 players) and a control group (three teams, 120 players). The intervention period was set to three seasons, and the players were followed up during this period. The one‐season effect of the FIFA 11+ was investigated after each season. The effect of continuous intervention was verified in 66 and 62 players from the intervention and control groups who continued the study for all three seasons, respectively. The one‐season intervention showed significantly lower total, ankle, knee, sprain, ligament injury, noncontact, moderate and severe injury incidence rates in the intervention group in each season. Regarding the continuous intervention, compared with the first season, the injury incidence rates in lower extremity, ankle, and sprain, decreased in the intervention group by 66.0%, 79.8%, and 82.2%, respectively, in the second season, and by 82.6%, 94.6%, and 93.4%, respectively, in the third season, indicating the persistent effect of the FIFA 11+. In conclusion, the FIFA 11+ is an effective program for lower extremity injury prevention in collegiate female football players, and preventive effects persist with continuation of the program.
The Influence of Fiber Orientation of the Conus Elasticus in Vocal Fold Modeling
Authors: Wang Xiaojian , Zheng Xudong , Xue Qian 
Published: May 2023

Abstract
While the conus elasticus is generally considered a part of continuation of the vocal ligament, histological studies have revealed different fiber orientations that fibers are primarily aligned in the superior-inferior direction in the conus elasticus and in the anterior-posterior direction in the vocal ligament. In this work, two continuum vocal fold models are constructed with two different fiber orientations in the conus elasticus: the superior-inferior direction and the anterior-posterior direction. Flow-structure interaction simulations are conducted at different subglottal pressures to investigate the effects of fiber orientation in the conus elasticus on vocal fold vibrations, aerodynamic and acoustic measures of voice production. The results reveal that including the realistic fiber orientation (superior-inferior) in the conus elasticus yields smaller stiffness and larger deflection in the coronal plane at the junction of the conus elasticus and ligament and subsequently leads to a greater vibration amplitude and larger mucosal wave amplitude of the vocal fold. The smaller coronal-plane stiffness also causes a larger peak flow rate and higher skewing quotient. Furthermore, the voice generated by the vocal fold model with a realistic conus elasticus has a lower fundamental frequency, smaller first harmonic amplitude, and smaller spectral slope.
Axial Crushing Behaviors of Metal Density Gradient Foam-Filled Square Taper Tubes: Analytical Model and Numerical Calculation
Authors: Wu Xiwei , Zhang Jianxun 
Published: May 2023

Abstract
Metal tube is a traditional energy-absorbing structure, and metal foam is a lightweight material with advantages, i.e., high energy absorption and high specific strength. The foam-filled square tube can improve crashworthiness and has better energy absorption, which is higher than the sum of the energy absorption of the tube and foam. Axial crushing behaviors of metal density gradient foam (DGF) filled square taper tubes are studied analytically and numerically in this paper. An analytical model is presented to study the crushing behavior of DGF-filled square taper metal tube under axial loading, in which the interaction between square taper tube and DGF is considered. The numerical calculation is conducted, and the deformation mode is obtained. The analytical predictions are well consistent with the experimental and numerical results. The influences of taper angle, foam strength, maximum relative density, and minimum relative density of gradient foam on the compressive behavior of metal DGF-filled square taper tubes under axial loading are considered. It is demonstrated that when the taper angle is less than 85 deg, the average crushing force increases as the minimum density of the DGF increases. However, when the taper angle is greater than 85 deg, the average crushing force decreases with the increase of the minimum density of the gradient. This proposed analytical model can effectively predict the axial crushing behaviors of metal DGF-filled square taper tubes.