bluuebunny/crossref_metadata_2025_split huggingface dataset:
Research on Improving Methods of Power Quality of Diesel Generators with Millisecond Pulse Load
Authors: Li Hai-Chao , Guo Yan-Shen , Huang Ke-Feng , Zhang Qian , Chen Mei-Yi , He Jiang-Jiang 
Published: March 2023

Abstract
Modern radar is a typical millisecond pulse load (MPL). Still, the independent power supply system of radar with a diesel generator (DG) as the main power source will have serious frequency fluctuation and voltage distortion problems. In practical applications, the main method to solve these problems is to increase the power supply capacity. This method will cause a serious waste of resources, and the mobility of the system will deteriorate. This paper takes the diesel generator with a millisecond pulse load system (DG_MPL) as the research object. It proposes a method to improve the power quality of DG_MPL by connecting the energy storage system (ESS) on the AC side. The system uses DG as the main power source and ESS as the auxiliary power source. The equivalent frequency regulation model is studied when the inverter control mode of ESS is selected PQ, Droop, and VSG, respectively. Finally, the system operating characteristics and power quality of several common improvement methods are compared and analyzed. The results prove that the proposed method can effectively improve the system frequency and voltage distortion problems.
Application of Multiscale Method in Nonlinear Vibration Problem of Multi-joint Manipulator
Authors: Chang HaiYang , Jiang ShanYing 
Published: March 2023

Abstract
In this paper, the nonlinear two-joint manipulator system is taken as the research object. Firstly, the dynamic equation of the system is established by using the Lagrange method. In the case of ignoring some high-order nonlinear terms in the equations, the multi-scale method in the nonlinear vibration approximate analytical method is used to solve the nonlinear multi-joint manipulator system model, and the approximate analytical solution of the system is obtained. The theoretical analysis results are verified by numerical calculation. The results show that the analytical solution is in good agreement with the numerical solution, which verifies the effectiveness and accuracy of the multi-scale method.
Sliding bifurcations of a two DOF self-excited SD oscillator with Coulomb friction
Authors: Li Zhixin , Li Zhiguo , Zhang Ke , Lu Jiaqi 
Published: March 2023

Abstract
In this study, on the basis of the SD (smooth and discontinuous) oscillator, we analyze the sliding bifurcations of a two DOF self-excited system driven by the classical conveyor belt friction. In order to elaborate the nonsmooth model named the self-excited SD oscillator, we model the friction of the conveyor belt of this system as Coulomb friction. Switching surfaces and sliding regions of this nonsmooth system are obtained based on the Filippov theory. The numerical simulations are performed to present the various scenarios of sliding bifurcation and chaotic attractors in the system. The results of this study give us an opportunity to understand clearly the bifurcation mechanism of the rich nonlinear frictional dynamics in machinery field.
Dynamic modeling and analysis of compound pendulum motion of projectile
Authors: Hang Zhang , Dong Chen , Binan Jiang , Qi Meng 
Published: March 2023

Abstract
The influence of air lift on the stability of inaccurate precision strike ammunition is studied, and the mechanical analysis of projectile and its flight stage is carried out. The dynamic equation of projectile under the action of air lift is established and simulated. The angular velocity and angular time-history curve of the compound pendulum motion of the projectile are obtained, and the correctness of the mechanical analysis of compound pendulum motion during flight is verified.
Analytic solution on force analysis of tripod in arbitrary space
Authors: Li Yun , Song Yumin 
Published: March 2023

Abstract
Tripod is a common support structure. The key to tripod design is to accurately analyze the force, select appropriate materials, and design the angle according to the size of the axial force. To study the stress condition and application performance of a tripod, this paper takes any tripod in space as the research object, through the combination of mathematics and mechanics, establishes a space rectangular coordinate system, solves the internal force of the tripod member, and verifies the correctness of the solution results. The evolution from arbitrary tripod structure to special tripod structure demonstrates the correctness of the reasoning method from general to special. An arbitrary space tripod is a common engineering application structure. Taking it as the research object, mechanical analysis has certain practical significance.
Performance of a spherical high pressure gas TPC for neutrino magnetic moment measurement
Authors: Bouet R. , Busto J. , Cecchini V. , Cerna C. , Charpentier P. , Dastgheibi-Fard A. , Druillole F. , Jollet C. , Hellmuth P. , Katsioulas I. , Knights P. , Giomataris I. , Gros M. , Lautridou P. , Meregaglia A. , Navick X.F. , Neep T. , Nikolopoulos K. , Perrot F. , Piquemal F. , Roche M. , Thomas B. , Ward R. 
Published: March 2023

Abstract
The measurement of neutrino magnetic moment larger than
10-19
μB
would be a clear signature of physics beyond the
standard model other than the existence of massive Dirac
neutrinos. The use of a spherical proportional counter detector
filled with gas at 40 bar located near a nuclear reactor would be a
simple way to perform such a measurement exploiting the developments
made on such a technology for the search of dark matter and
neutrinoless double beta decay. Different targets can be used just
by replacing the gas: xenon, CF4 and argon were compared and the
sensitivity in one year of data taking could reach the level of
4.3 × 10-12
μB
, 6.5 × 10-12
μB
, and
8.5 × 10-12
μB
, respectively.
Abelian sandpiles on cylinders
Authors: Eckmann Jean-Pierre , Nagnibeda Tatiana , Perriard Aymeric 
Published: March 2023

Abstract
We study the Abelian sandpile model on a special playground, a cylinder of width w and of circumference c. When

c
≪
w

, we describe a phenomenon which has not been observed in other geometries: the probability distribution of avalanche sizes has a ladder structure, with the first step consisting of avalanches of size up to

w
⋅
c

/

2

that are essentially equiprobable, except for a small exponential tail of order about 10 c. We explain this phenomenon and describe subsequent steps.
DeepFormer: a hybrid network based on convolutional neural network and flow-attention mechanism for identifying the function of DNA sequences
Authors: Yao Zhou , Zhang Wenjing , Song Peng , Hu Yuxue , Liu Jianxiao 
Published: March 2023

Abstract
Identifying the function of DNA sequences accurately is an essential and challenging task in the genomic field. Until now, deep learning has been widely used in the functional analysis of DNA sequences, including DeepSEA, DanQ, DeepATT and TBiNet. However, these methods have the problems of high computational complexity and not fully considering the distant interactions among chromatin features, thus affecting the prediction accuracy. In this work, we propose a hybrid deep neural network model, called DeepFormer, based on convolutional neural network (CNN) and flow-attention mechanism for DNA sequence function prediction. In DeepFormer, the CNN is used to capture the local features of DNA sequences as well as important motifs. Based on the conservation law of flow network, the flow-attention mechanism can capture more distal interactions among sequence features with linear time complexity. We compare DeepFormer with the above four kinds of classical methods using the commonly used dataset of 919 chromatin features of nearly 4.9 million noncoding DNA sequences. Experimental results show that DeepFormer significantly outperforms four kinds of methods, with an average recall rate at least 7.058% higher than other methods. Furthermore, we confirmed the effectiveness of DeepFormer in capturing functional variation using Alzheimer’s disease, pathogenic mutations in alpha-thalassemia and modification in CCCTC-binding factor (CTCF) activity. We further predicted the maize chromatin accessibility of five tissues and validated the generalization of DeepFormer. The average recall rate of DeepFormer exceeds the classical methods by at least 1.54%, demonstrating strong robustness.
Topical tacrolimus versus corticosteroids in childhood moderate-to-severe atopic dermatitis and the impact on airway inflammation: a long-term randomized open-label study
Authors: Perälä Miia , Salava Alexander , Malmberg Pekka , Pelkonen Anna S , Mäkelä Mika J , Remitz Anita 
Published: March 2023

Abstract

Background
Childhood atopic dermatitis (AD) is often followed by other atopic comorbidities such as asthma.

Aim
To compare the effectiveness of topical tacrolimus (TAC) and topical corticosteroids (TCSs) and their impact on airway inflammation and bronchial hyperresponsiveness in patients with paediatric AD.

Methods
This was a 3-year randomized open-label comparative follow-up study of 152 1–3-year-old children with moderate-to-severe AD (trial registration: EudraCT2012-002412-95). Frequent study visits including clinical examinations, laboratory investigations (total IgE, specific IgEs, blood eosinophils), skin prick and respiratory function tests to assess airway inflammation and bronchial hyperresponsiveness (exhaled nitric oxide, airway responsiveness to exercise and methacholine) were performed.

Results
Changes in eczema parameters at 36 months were similar in the TCS and TAC groups for mean body surface area (BSA) difference 1.4 [95% confidence interval (CI) –1.48 to 4.19); P = 0.12], mean Eczema Area and Severity Index (EASI) difference 0.2 (95% CI –1.38 to 1.82; P = 0.2), mean Investigator’s Global Assessment (IGA) difference, 0.3 (95% CI –0.12 to 0.67; P = 0.12) and mean transepidermal water loss (TEWL) difference at the eczema site, –0.3 (95% CI –4.93 to 4.30; P = 0.96) and at the control site, 1.4 (95% CI –0.96 to 3.60, P = 0.19). The control-site TEWL increased more towards the end of follow-up in the TCS vs. TAC group (mean change difference –4.2, 95% CI –8.14 to –0.29; P = 0.04). No significant impact on development of airway inflammation or bronchial hyperresponsiveness occurred in early effective eczema-treatment responders vs. others (‘early’ vs. ‘other’ response was defined as the difference in treatment response to airway outcomes in BSA, EASI or IGA at 3 months).

Conclusion
Children with moderate-to-severe AD benefit from long-term treatment with TCS or TAC. There were no significant differences in treatment efficacy. No differences in the impact on airways occurred between early effective treatment responders vs. others.
Pipelined Decision Trees for Online Traffic Classification on FPGAs
Authors: Erdem Oğuzhan , Soylu Tuncay , Carus Aydın 
Published: March 2023

Abstract
Decision tree (DT)-based machine learning (ML) algorithms are one of the preferred solutions for real-time internet traffic classification in terms of their easy implementation on hardware. However, the rapid increase in today’s newly developed applications and the resulting diversity in internet traffic greatly increases the size of DTs. Therefore, the tree-based hardware classifiers cannot keep up with this growth in terms of resource usage and classification speed. To alleviate the problem, we propose to group application classes by certain rules and create an individual small DT per each group. In this article, a pipelined organization of multiple DT data structures, called pipelined decision trees, is proposed as a scalable solution to tree-based traffic classification. We also propose two distinct algorithms, namely confusion matrix-based class aggregation and leaf count-based class aggregation algorithms, to set group creation rules that allows traffic classification on pipelined smaller DTs in a hierarchical order. We further designed an hardware engine on field programmable gate arrays, which can search those pipelined trees within a single clock cycle by transforming them into bit vectors and implementing multiple range comparisons in parallel. Our architecture with 12 classes can run in 928.88 giga bit per second and achieve 96.04% accuracy.
Hybrid inferiority and genetic incompatibilities drive divergence of fungal pathogens infecting the same host
Authors: Yuzon Jennifer D , Wyatt Nathan A , Vasighzadeh Asieh , Clare Shaun , Navratil Emma , Friesen Timothy L , Stukenbrock Eva H 
Published: March 2023

Abstract
Agro-ecosystems provide environments that are conducive for rapid evolution and dispersal of plant pathogens. Previous studies have demonstrated that hybridization of crop pathogens can give rise to new lineages with altered virulence profiles. Currently, little is known about either the genetics of fungal pathogen hybridization or the mechanisms that may prevent hybridization between related species. The fungus Pyrenophora teres is a global pathogen of barley. The pathogenic fungus P. teres exists as two distinct lineages P. teres f. teres and P. teres f. maculata (Ptt and Ptm, respectively), which both infect barley but produce very distinct lesions and rarely interbreed. Interestingly, Ptt and Ptm can, by experimental mating, produce viable progenies. Here, we addressed the underlying genetics of reproductive barriers of P. teres. We hypothesize that Ptt and Ptm diverged in the past, possibly by adapting to distinct hosts, and only more recently colonized the same host in agricultural fields. Using experimental mating and in planta phenotyping in barley cultivars susceptible to both P. teres forms, we demonstrate that hybrids produce mixed infection phenotypes but overall show inferior pathogenic fitness relative to the pure parents. Based on analyses of 104 hybrid genomes, we identify signatures of negative epistasis between parental alleles at distinct loci (Dobzhansky–Müller incompatibilities). Most DMI regions are not involved in virulence but certain genes are predicted or known to play a role in virulence. These results potentially suggest that divergent niche adaptation—albeit in the same host plant—contributes to speciation in P. teres.
Genetic modifiers modulate phenotypic expression of tafazzin deficiency in a mouse model of Barth syndrome
Authors: Wang Suya , Yazawa Erika , Keating Erin M , Mazumdar Neil , Hauschild Alexander , Ma Qing , Wu Haiyan , Xu Yang , Shi Xu , Strathdee Douglas , Gerszten Robert E , Schlame Michael , Pu William T 
Published: March 2023

Abstract
Barth syndrome is an X-linked disorder caused by loss-of-function mutations in Tafazzin (TAZ), an acyltransferase that catalyzes remodeling of cardiolipin, a signature phospholipid of the inner mitochondrial membrane. Patients develop cardiac and skeletal muscle weakness, growth delay and neutropenia, although phenotypic expression varies considerably between patients. Taz knockout mice recapitulate many of the hallmark features of the disease. We used mouse genetics to test the hypothesis that genetic modifiers alter the phenotypic manifestations of Taz inactivation. We crossed TazKO/X females in the C57BL6/J inbred strain to males from eight inbred strains and evaluated the phenotypes of first-generation (F1) TazKO/Y progeny, compared to TazWT/Y littermates. We observed that genetic background strongly impacted phenotypic expression. C57BL6/J and CAST/EiJ[F1] TazKO/Y mice developed severe cardiomyopathy, whereas A/J[F1] TazKO/Y mice had normal heart function. C57BL6/J and WSB/EiJ[F1] TazKO/Y mice had severely reduced treadmill endurance, whereas endurance was normal in A/J[F1] and CAST/EiJ[F1] TazKO/Y mice. In all genetic backgrounds, cardiolipin showed similar abnormalities in knockout mice, and transcriptomic and metabolomic investigations identified signatures of mitochondrial uncoupling and activation of the integrated stress response. TazKO/Y cardiac mitochondria were small, clustered and had reduced cristae density in knockouts in severely affected genetic backgrounds but were relatively preserved in the permissive A/J[F1] strain. Gene expression and mitophagy measurements were consistent with reduced mitophagy in knockout mice in genetic backgrounds intolerant of Taz mutation. Our data demonstrate that genetic modifiers powerfully modulate phenotypic expression of Taz loss-of-function and act downstream of cardiolipin, possibly by altering mitochondrial quality control.
Psychometric Performance of Fatigue Scales in Inflammatory Bowel Disease
Authors: Marrie Ruth Ann , Fisk John D , Dolovich Casandra , Lix Lisa M , Graff Lesley A , Patten Scott B , Bernstein Charles N 
Published: March 2023

Abstract

Background
Fatigue is highly prevalent in people with inflammatory bowel disease (IBD). Fatigue scales are important for studies testing fatigue interventions, but information about psychometric properties of many scales is insufficient in IBD. We compared the psychometric properties of multiple generic fatigue scales in participants with IBD.

Methods
Individuals with IBD (N = 216) completed the Daily Fatigue Impact Scale (DFIS), the vitality subscale of the RAND-36, and the Patient Health Questionnaire-9 (PHQ-9) fatigue item twice. A subgroup (n = 84) also completed the Fatigue Impact Scale (FIS) once, from which we also scored the 21 items from the Modified Fatigue Impact Scale (MFIS-IBD). We assessed floor/ceiling effects, construct validity, and internal consistency reliability. Using relative efficiency (RE), we compared discriminating ability and comparative responsiveness of the measures regarding disease activity and employment status and changes.

Results
The FIS, MFIS, and RAND-36-vitality scales did not exhibit floor or ceiling effects. The DFIS showed mild floor effects (19.4%), and the PHQ-9 fatigue item showed floor (18.1%) and ceiling (20.8%) effects. Internal consistency reliability exceeded 0.93 for FIS, MFIS-IBD, and DFIS and was 0.81 for the RAND-36-vitality scale. In the subgroup analysis, the FIS, MFIS-IBD, and DFIS were strongly correlated with each other (r ≥ 0.90). The ability to discriminate between disease activity groups was highest for the FIS and MFIS-IBD, followed by the DFIS. The FIS, MFIS-IBD, and DFIS were responsive to changes in work impairment.

Conclusions
The FIS, MFIS-IBDs and DFIS had adequate validity and reliability for assessing fatigue in IBD.
The Curious Case of Judicial Interpretation and Labour Flexibility in India
Authors: Balasubramanian Girish , Talluri Surendra Babu , Sarkar Santanu 
Published: March 2023

Abstract
The economic liberalisation of the 1990s in India led to calls for increased labour flexibility. As achieving legislative reform proved difficult, the focus shifted to judicial interpretation of existing labour statutes. We present evidence that Indian courts changed their interpretations of labour laws over time, favouring flexibility at the expense of the protective purposes underlying the legislation. Our study is based on analysis of a sample of 196 judgments of senior appellate courts between 1999 and 2019 on protective provisions of the Contract Labour (Regulation and Abolition) Act 1970. The tendency of the Indian courts to support interpretations consistent with the goal of labour flexibility may be said to illustrate the role of the judiciary in promoting market-led economic development, but it also suggests a degree of bias in the courts’ approach to questions of labour law adjudication.
Where Should Multinationals Pay Taxes?
Authors: Arel-Bundock Vincent , Blais André 
Published: March 2023

AbstractThe international tax system is a pillar of the post-war economic order, but it faces major challenges with the rise of global value chains, digitalization, and tax avoidance. Debates over international tax reform usually occur within a small epistemic community of experts and technocrats. In this article, we step outside this restricted circle to assess the sources of bottom-up legitimacy and support for the rules that govern where multinationals must report profits and which governments are entitled to tax those profits. We conduct survey experiments in Brazil, France, and the United States to assess mass attitudes toward the allocation of the tax base across countries. We find that people’s views clash with the core principles of the current regime, but are aligned with reform proposals that allocate more taxing rights to market jurisdictions. These findings are strikingly consistent across three countries and three distinct studies. At first glance, the consistency of attitudes across countries could spell good things for international cooperation in this arena. However, we also find a significant level of “home bias” in the public’s views on tax allocation. These results shed new light on the legitimacy of tax reform and on the prospects for cooperation in a key area of international economic relations.
Brevicillin, a novel lanthipeptide from the genusBrevibacilluswith antimicrobial, antifungal, and antiviral activity
Authors: Singh Shelley Sardul , Sharma Deepika , Singh Charandeep , Kumar Sahil , Singh Prashant , Sharma Anshul , Das Deepjyoti Kumar , Pinnaka Anil Kumar , Thakur Krishan Gopal , Ringe Rajesh P , Korpole Suresh 
Published: March 2023

AbstractAimThis study was aimed to determine antimicrobial and antiviral activity of a novel lanthipeptide from a Brevibacillus sp. for disinfectant application.Methods and resultsThe antimicrobial peptide (AMP) was produced by a bacterial strain AF8 identified as a member of the genus Brevibacillus representing a novel species. Whole genome sequence analysis using BAGEL identified a putative complete biosynthetic gene cluster involved in lanthipeptide synthesis. The deduced amino acid sequence of lanthipeptide named as brevicillin, showed &gt;30% similarity with epidermin. Mass determined by MALDI-MS and Q-TOF suggested posttranslational modifications like dehydration of all Ser and Thr amino acids to yield Dha and Dhb, respectively. Amino acid composition determined upon acid hydrolysis is in agreement with core peptide sequence deduced from the putative biosynthetic gene bvrAF8. Biochemical evidence along with stability features ascertained posttranslational modifications during formation of the core peptide. The peptide showed strong activity with 99% killing of pathogens at 12 μg ml−1 within 1 minute. Interestingly, it also showed potent anti-SARS-CoV-2 activity by inhibiting ∼99% virus growth at 10 μg ml−1 in cell culture-based assay. Brevicillin did not show dermal allergic reactions in BALB/c mice.ConclusionThis study provides detailed description of a novel lanthipeptide and demonstrates its effective antibacterial, antifungal and anti-SARS-CoV-2 activity.
Congenital diverticulum of the vermiform appendix: a rare finding of a routine operation
Authors: Padar Maria , Mudalige Vijitha P 
Published: March 2023

AbstractCongenital diverticulum of the appendix as well as diverticulitis of the vermiform appendix remain a rare, mainly retrospective diagnosis, reported by the pathologist, post-appendicectomy. In clinical practice, however, it is important to be aware of this entity, the different types, diagnosis, association with malignancy and treatment options. We are presenting a young female case of pathologically proved true diverticulum of the appendix with associated uncomplicated appendicitis and an overview of the literature.
Utility of a Viral Vesicular Panel Multiplex Polymerase Chain Reaction Assay for the Diagnosis of Monkeypox, Herpes Simplex, and Varicella Zoster Viruses
Authors: Wilber Eli , Rebolledo Paulina A , Kasinathan Vyjayanti , Merritt Stephanie , Titanji Boghuma K , Aldred Bruce , Kandiah Sheetal , Ray Susan M , Sheth Anandi N , Colasanti Jonathan A , Wang Yun F 
Published: March 2023

AbstractMpox (monkeypox) represents a diagnostic challenge due to varied clinical presentations and multiple mimics. A commercially available multiplex polymerase chain reaction panel accurately detects mpox virus as well as common mimics (herpes simplex virus, varicella zoster virus) in clinical specimens and could be used in routine clinical, surveillance, and outbreak settings.