bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ventilation efficacy during Paediatric Cardiopulmonary Resuscitation (PEDIVENT): Simulation-based Comparative Study
Authors: Skříšovska Tamara , Kosinová Martina , Djakow Jana , Jabandžiev Petr , Kramplová Tereza , Klučka Jozef , Agalarev Viktor , Štourač Petr 
Published: March 2023

Abstract
Background: To our knowledge, this is the first study concerning the effectiveness of 5 initial breaths and subsequent ventilation during paediatric resuscitation. The recommendations on initial resuscitation in unresponsive non-breathing children differ worldwide. Most cardiac arrests in children are secondary (hypoxic or asphyctic in origin) and ventilation during resuscitation is associated with better neurological outcomes. However, it is not clear whether the particular introduction sequence of paediatric resuscitation has any impact on the outcomes and if the effectiveness of ventilation could be improved by simulation based training.
Methods: The aim of this prospective simulation-based comparative study was to evaluate the ventilation efficacy during paediatric cardiopulmonary resuscitation (CPR) provided by health care professionals (HCP) and lay rescuers (LR). The primary outcome was the number of effective breaths during 5 initial CPR breaths. The secondary outcomes were: sub-analysis of 2 first ventilation attempts, time to first effective ventilation, time to 5 and 2 effective breaths, number and percentage of 5 initial breath attempts with ideal, low and high volume, and time to the chest compressions initiation. All parameters were measured before and after structured simulation based training. HCPs and LRs performed 90 seconds of CPR on 2 mannequins: 5 kg Baby and 20 kg Junior. The HCPs provided bag-mask ventilation; LR performed dispatcher-assisted CPR with mouth-to-mouth ventilation.
Results: Data were obtained from 40 HCPs and 46 LRs. Significant improvement in the number of effective ventilations before and after the training in Baby was in HCPs 26 (65%) vs. 40 (100%) and in LRs 28 (60.9%) vs. 45(97.8%), (both P˂0.001). In Junior the improvement was significant only in the LR group 32 (82.1%) vs. 37 LR (94.9%), P=0.005), but not in the HCPs group (31 HCPs before (77.5%) and 32 HCPs after structured training (82.1%), (P=0.77).
Conclusion: The structured training improved the number of effective ventilation during simulated paediatric CPR performed by health care professionals and lay rescuers.
Trial Registration: This study is registered at ClinicalTrials.gov (ID: NCT05345704)
Chatting with ChatGPT: Investigating the Impact on Psychological Well-being and Self-esteem with a Focus on Harmful Stereotypes and Job Anxiety as Moderator.
Authors: Salah Mohammed , Alhalbusi Hussam , Abdelfattah Fadi , Ismail Maria Mohd 
Published: March 2023

Abstract
Artificial Intelligence (AI) technology has revolutionized how we interact with information and entertainment, with ChatGPT, a language model developed by OpenAI, one of its prominent applications. However, there is limited knowledge of the psychological impact of interacting with ChatGPT. This study aims to investigate the relationships between trust in ChatGPT, user perception of ChatGPT, stereotype perception of ChatGPT, and two psychological outcomes: psychological well-being and self-esteem. The study hypothesizes that trust in ChatGPT, user perception of ChatGPT, and stereotype perception of ChatGPT have a positive direct relationship with self-esteem. Additionally, the study proposes that the relationship between trust in ChatGPT, user perception of ChatGPT, and psychological well-being is moderated by job anxiety. Using a survey design, data were collected from a sample of participants (n = 732), and the relationships between the variables were analyzed using regression analysis. The results indicate that stereotype perception of ChatGPT significantly predicts self-esteem, while user perception of ChatGPT and trust in ChatGPT have a positive direct relationship with self-esteem. The study also found that job anxiety moderates the relationship between user perception of ChatGPT and psychological well-being. The study provides important insights into the psychological effects of interacting with AI technology and highlights the role of job anxiety in moderating these effects. These findings have implications for the development and use of AI technology in various fields, such as mental health and human-robot interactions.
Screening of diagnostic biomarkers for Ferroptosis-related osteoarthritis and construction of a risk-prognosis model
Authors: Yan Yiqun , Cheng Wendan , Yu Haoran , He Junyan , Wang Changming 
Published: March 2023

Abstract
Background
Osteoarthritis (OA) is the most prevalent and commonly chronic joint disease that frequently develops among the elderly population. It is not just a single tissue that is affected, but rather a pathology involving the entire joint. Among them, synovitis is a key pathological change in OA. Ferroptosis is a newly discovered form of cell death that results from the buildup of lipid peroxidation. However, the role and impact of it in OA are yet to be explored.
Objective
The key to this work is to uncover the mechanisms of ferroptosis-related OA pathogenesis and develop more novel diagnostic biomarkers to facilitate the diagnostic and therapeutic of OA.
Materials and Methods
Download FRGs and OA synovial chip datasets separately from the FerrDB and GEO databases. Identify FDEGs using R software, obtain the intersection genes through two machine learning algorithms, and obtain diagnostic biomarkers after logistic regression analysis. Verify the diagnostic and therapeutic efficacy of specific genes for OA through the construction of clinical risk prognostic models using ROC curves and nomogram. Simultaneously, correlations between specific genes and OA immune cell infiltration co-expression were constructed. Finally, verify the differential presentation of specific genes in OA and HC synovium.
Results
Obtain 38 FDEGs through screening. Based on machine learning algorithms and logistic regression analysis, select AGPS, BRD4, RBMS1, and EGR1 as diagnostic biomarker genes. The diagnostic and therapeutic efficacy of the four specific genes for OA has been validated by ROC curves and nomogram of clinical risk prognostic models. The analysis of immune cell infiltration and correlation suggests a close association between specific genes and OA immune cell infiltration. Further revealing the diagnostic value of specific genes for OA by the differential presentation analysis of their differential presentation in synovial tissue from OA and HC.
Conclusion
This study identified four diagnostic biomarkers for OA that are associated with iron death. The establishment of a risk-prognostic model is conducive to the premature diagnosis of OA, evaluating functional recovery during rehabilitation, and guidance for subsequent treatment.
Mediating Effect of Non-Exercise Estimation of Cardiorespiratory Fitness on Relationship Between Physical Comorbidity and Depression in Korean Adult Cancer Survivors
Authors: Jin Youngyun , Kim Taewan , Kim Donghyun 
Published: March 2023

Abstract
To determine relationship between physical comorbidity (PC) and depression in Korean adults’ cancer survivors and understand if non-exercise estimation of cardiorespiratory fitness (eCRF) might have a mediating effect on such relationship. Data of 448 cancer survivors aged 20–64 years old in Korean National Health and Nutrition Examination Survey Ⅶ-Ⅷ (2016–2020) were analyzed. Depression was assessed with a 9-item Patient Health Questionnaire (PHQ-9). Subjects were categorized into two groups: normal and depression. PC was defined if a participant was diagnosed by a physician or was being treated at the time of the survey. eCRF was determined with sex and age-specific algorithms. In the mediation model, PC (β = 1.836, 95%CI: 1.577 to 2.095, p < 0.001) was significantly association with depression and eCRF levels mediated (indirect effect = 0.094, bootstrap 95%CI: 0.028 to 0.146) this association. Mediation analysis showed a significant, direct, and indirect effect with a significant Sobel test value (z = 2.517, p = 0.011). The relationship between PC and depression was significantly mediated by eCRF levels. Early physical activity interventions might prevent depression in cancer survivors with chronic diseases.
Underwater Acoustic Performance of SiC Foam Ceramic Materials
Authors: Şahiner Barış , Baykara Tarık , Ozbek Sunullah , Demirural Alparslan 
Published: March 2023

Abstract
One of the major tasks of the underwater warfare is to detect underwater objects such as vehicles, vessels, weapons and equipment. The conduct of underwater warfare mostly depends upon the advancement of detection and identification sensors and materials. The wide variation in types and characteristics of materials may affect the underwater detection capabilities despite recently developed sonar systems. The materials with high porosity are known to provide lower acoustical signature than conventional metallic plates in common. The aim of this study is to examine the acoustical signature and the efficiency of open celled SiC foam ceramics as covering and/or casing material for naval mines. Sonar frequencies widely used in mine countermeasure operations for detection purposes, 80kHz, 85kHz, 90khZ, 95kHz and 100kHz were applied to the acoustic tests. The experimental results obtained from the study shows that the SiC foam ceramic plate leads a 19,2% reduction in reflection, 90,5 % and 96 % lower values are obtained in transmission and 78,4 % and 68,6 % lower values are obtained at 60° and 30° in scattering compared to the reference steel plate.
Application of Minnan folk light and shadow animation in built environment in object detection algorithm
Authors: Wu Sichao , Wu Shengzhen 
Published: March 2023

Abstract
For the problems of deep convolutional neural network model with many parameters and memory resource consumption, a lightweight network-based algorithm for building detection of Minnan folk light SAR images is proposed. Firstly, based on the rotating target detection algorithm R-centernet, the Ghost ResNet network is constructed to reduce the number of model parameters by replacing the traditional convolution in the backbone network with Ghost convolution. Secondly, a channel attention module integrating width and height information is proposed to enhance the network's ability to accurately locate salient regions in folk light images.CARAFE upsampling is used to replace the DCN module in the network to fully incorporate feature map information during upsampling to improve target detection. Finally, the constructed dataset of rotated and annotated light and shadow SAR images is trained and tested using the improved R-centernet algorithm. The experimental results show that the improved algorithm improves the accuracy by 3.8%, the recall by 1.2%, and the detection speed by 12 frames/second compared with the original R-centernet algorithm.
How does water management impact the effects of straw returning on biological nitrogen fixation and diazotrophs?
Authors: Zhang Yanhui , Hu Tianlong , Wang Hui , Liu Qi , Wang Jing , Chen Zhe , Shu Liangzuo , Xie Zubin 
Published: March 2023

Abstract
Background and aims
Both straw incorporation and water management affect biological nitrogen fixation (BNF), but it is unclear how water management impact the effects of straw returning on BNF and diazotrophs in rice fields.
Methods
A 15N2-labelling system was used to determine BNF under straw returning with continuous or intermittent flooding in rice field for 90 days. The nitrogenase nifH gene and nifH RNA gene (cDNA) were amplified by qPCR and the community structure of diazotroph was studied by high-throughput sequencing of nifH DNA gene.
Results
Combined continuous flooding and straw incorporation, BNF was 14.29 kg ha-1, which was much higher than 6.62 kg ha-1 under straw incorporation and intermittent flooding. Straw incorporation and continuous flooding showed an obvious synergistic effects on BNF, nifH DNA gene copy number and nifH cDNA gene copy number. The increased effects were mainly attributed to the increase of heterotrophic diazotrophs Desulfovibrionaceae, Azonexus and Azotobacter.
Conclusions
In conclusion, straw incorporation under continuous flooding could increase BNF greatly than under intermittent flooding. The results indicated that combined straw incorporation and continuous water flooding could build soil fertility faster.
A Rare Incidence of Metastatic Papillary Thyroid Carcinoma to the Mandible: A Case Report and Review of Literature
Authors: Raffaelli Samuel D. , Shupak Raymond P. , Winstead Michael , Hockaday Joshua J. , Kim Roderick Y. 
Published: March 2023

Abstract
Papillary Thyroid Carcinoma (PTC) primarily metastasizes via regional lymphatics making its spread to the oral cavity exceedingly rare. Although this disease remains the most common endocrine malignancy, comprising roughly 85%-90% of all thyroid cancers, it’s occurrence within the oral cavity is seldom seen. This study identifies a case report involving a 77-year-old male with a past medical history of well-differentiated PTC that was initially treated with a total thyroidectomy and adjuvant radioactive iodine. Approximately five years after his initial treatment, surveillance imaging demonstrated a 3.0 x 1.8 x 2.0 cm expansile mass at the left mandibular body with erosion of the lingual cortex. An incisional biopsy then confirmed the diagnosis of metastatic papillary thyroid carcinoma. The patient was treated with a segmental resection of his mandible and final reconstruction utilizing a fibula free flap. Given the limited number of cases involving metastatic spread of PTC to the head and neck region, a standardized treatment algorithm does not currently exist. Thus, this case serves to provide a documented report of this rare occurrence and to review literature that may help other clinicians treat patients with this malignancy type. There remains a need for future studies to create risk stratification models for patients with metastatic PTC that consider margin analysis, genetic characteristics, and elevated risk factors for metastasis to tailor individual treatment plans.
Determinantal point processes associated with Bergman kernels: Construction and limit theorems
Authors: Lemoine Thibaut 
Published: March 2023

Abstract
We study determinantal point processes whose correlation kernel is the Bergman kernel of a high power of a positive Hermitian holomorphic line bundle over a compact complex manifold. We construct such processes in analogy to the orthogonal ensembles in random matrix theory, where the correlation kernel is the famous Christoffel-Darboux kernel. Using a near-diagonal expansion of the Bergman kernel, we prove that the scaling limit of these point processes is given by a multidimensional generalization of the infinite Ginibre ensemble. As an application, we obtain a convergence in probability of their empirical measures to an equilibrium measure related to the complex Monge-Ampère equations. We finally establish a large deviation principle for weighted versions of these processes, whose rate function is the Legendre-Fenchel transform of the Mabuchi functional.
MSC Classification: 32Q10 , 60B20 , 60D05 , 60F05 , 60F10
Chromosome 4q deletion syndrome: 4q13.3-q21.23 deletion syndrome with mental retardation, congenital heart disease: a case report and literature review
Authors: Wang Dan , Huang Chuican , Luo Qing , Huang Zhengning , Zhang Cheng , Fan Li-Chun 
Published: March 2023

Abstract
Objective. Chromosome 4q deletion syndrome is a rare disease, and the reported genotypes cannot fully explain the clinical manifestations. This article aims to present a case that provides ideas for the clinical diagnosis of similar conditions, by adding new genotypes to the 4q deletion fragment gene pool.
Case presentation.A female child aged 7-month and 3-day-old was born after repeated treatments for “cleft palate, atrial septal defect, mixed deafness, corpus callosum developmental malformation” and other diseases. By searching the PubMed, and Web of Science, CNKI, the published literature on chromosome 4 deletion was sorted and analyzed. Whole-genome sequencing,which was diagnosed as 4q13.3-q21.23 deletion syndrome.
Conclusion.The diagnosis of congenital heart defects, progressive growth retardation, and mental retardation with multisystem involvement, and deletion of a gene fragment of chromosome 4 became a disorder to be considered in clinical work. Timely analysis of genetic findings could help confirm the diagnosis.
In-depth exploration on the mechanism of various dopant ions on the infrared electrochromic characteristics based on poly(3,4-ethylenedioxythiophene) conducting polymers
Authors: Tan Peiyu , Lu Feifei , Han Yuge 
Published: March 2023

Abstract
Poly(3,4-ethylenedioxythiophene) (PEDOT) is considered as an outstanding electrochromic material owing to its inherent infrared (IR) electrochromic properties, which has extensively application potential in intelligent IR thermal management. Although widespread studies concentrating on enhancing the IR electrochromic performances of PEDOT and much research showing that dopants significantly affect IR modulation, few experiments have deeply investigated the underlying mechanism. Herein, eight commonly dopantswere adopted to fabricate PEDOT film via in situ electrochemical deposition, and the IR electrochromic mechanism of PEDOT was further illuminated. Integrating Raman analyses, UV-Vis-NIR spectra, XPS analysis, FTIR spectra and DFT calculation, it is of significance to find that the generation and removal of polarons and bipolarons delocalized on PEDOT chains determine the reflectance regulation of PEDOT films. Where the positively polarized sulfur atoms in the thiophene rings can be viewed as the explicit manifestation of abstract polarons and bipolarons, i.e., charge carriers in the PEDOT chains. Additionally, the diverse IR control capabilities of various doped PEDOT devices are mainly resulted from the disparate charge carrier concentration of the oxidized state. Among the eight doped PEDOT devices, PSSNa-doped PEDOT owns the highest carrier concentration in the oxidized state and thus introduces the largest IR modulation amplitude of 0.566 in the wavelength scope of 3-5 μm.
Identification of potential biomarkers associated with dilated cardiomyopathy by bioinformatics analysis
Authors: Wu Xiang , Liu Huayang , Zhang Ming , Lin Daobin , Chen Kaili , Zhao Wei-nan 
Published: March 2023

Abstract
Background: The clinical diagnosis of Dilated Cardiomyopathy (DCM) is extremely difficult due to the lack of appropriate diagnostic markers and targets for intervention. In this study, reliable biomarker genes were screened by bioinformatics methods to provide guidance for the diagnosis of DCM.
Results: The Turquoise module was identified as the most relevant gene module for DCM disease by WGCNA, and then eight biomarker genes were identified by both LASSO analysis and SVM. Ten Hub genes were screened by protein interaction network and compared with the biomarker genes screened by WGCNA, the HSPA8 gene was overlapping.
Conclusion: The HSPA8 gene is the gene with the greatest weight of influence on DCM disease screened in this study, and further development for HSPA8 is expected to provide targets for the diagnosis and treatment of DCM.
Stable equilibrium dynamics explains continental lithosphere deformation
Authors: Kumar Ajay , Cacace Mauro , Scheck-Wenderoth Magdalena 
Published: March 2023

Abstract
Plate tectonics theory postulates the existence of rigid mobile plates, however, what defines and controls their internal deformation, particularly within continents, is not well understood. Using data-driven thermomechanical modelling of the Alpine Himalayan Collision Zone, we hypothesize that deviations from an equilibrium state between mantle dynamics, plate-boundary forces, and the thermochemical configuration of the lithosphere controls continental deformation. The balance between the plate’s internal energy and tectonic forces is quantified by a critical crustal thickness that matches the global average of present-day continental crust. Thicker intraplate domains than the critical crust (orogens) undergo weakening due to their increased internal energy, and dissipate their acquired energy within diffused zone of deformation, unlike the localized deformation seen along plate boundaries. This dissipative evolution is controlled by the feedback between thermal and mechanical relaxation of the out of balance energy in the orogenic lithosphere. Potential runaway instabilities, exponentially growing oscillations, are efficiently dampened by enhanced dissipation from radioactive heat sources. This ultimately drives orogens with their thickened radiogenic crust towards a final equilibrium state. Our results suggest a genetic link between the thermochemical state of the crust and the tectonic evolution of silicate Earth-like planets.
Prognostic utility of 99mTc-MIBI single photon emission computerized tomography myocardial perfusion imaging in patients with ischemia and non-obstructive coronary artery disease
Authors: Wang Xiaohui , Li Mengdan , Xie Fuxiang , Liang Huan , Yang Lu , Wei Xiaofei , Wang Zhengjie , Jing Xingguo 
Published: March 2023

Abstract
Purpose
The prognosis of patients with ischemia and non-obstructive coronary artery disease (INOCA) remains controversial; most do not undergo accurate disease evaluation and treatment, and the symptoms recur. Here, we used single-photon emission computed tomography myocardial perfusion imaging (SPECT MPI) to evaluate patients with INOCA. We sought to stratify patients more accurately and thus derive more reliable prognostic information.
Materials and methods
In total, 167 patients with INOCA were enrolled. All underwent invasive coronary angiography (CAG) and SPECT MPI within 1 week. The patients were divided into different groups according to their test results. Patients were followed-up regularly in terms of major adverse cardiovascular events (MACEs), including cardiac death, nonfatal myocardial infarction, stroke, re-hospitalization with angina pectoris, and recurrent angina pectoris. Kaplan-Meier curves and Cox’s proportional hazards models were used to analyze survival and identify predictive factors.
Results
Adverse cardiac events occurred in 33 cases (19.8%). The rate of MACEs was higher in the summed stress score (SSS) ≥ 4 group than in the SSS 0–3 group (30.1% vs 9.5%, respectively, P = 0.001) and event-free survival was lower (annual survival of 87.5% vs 96.2%, respectively, P = 0.003). Event-free survival was consistently higher in patients with normal arteries than in those with non-obstructive coronary artery disease (annual survival rates of 96.1% and 88.4%, P = 0.035). When the SSS scores and the CAG results were combined, patients with normal coronary arteries (SSS 0–3) had the best prognosis and those with non-obstructive coronary artery stenosis (SSS ≥ 4) had the worst. However, the early prognosis of patients with non-obstructive coronary artery disease and SSS scores of 0–3 was comparable to that of patients with normal coronary arteries and SSS scores ≥ 4 (annual survival rates of 100%, 94.6%, 93.1%, and 78.2%, respectively). Multivariate Cox’s regression indicated that the SSS score (hazard ratio [HR] = 1.126, 95% confidence interval [CI] 1.042–1.217, P = 0.003) and non-obstructive coronary artery disease (HR = 2.559, 95% CI 1.249–5.246, P = 0.01) were predictors of adverse cardiac events.
Conclusion
SPECT MPI data were prognostic for INOCA patients, thus identifying groups at high risk. The long-term predictive efficacy of such data exceeded that of CAG data. A combination of the two measures more accurately stratified INOCA patients in terms of risk.