bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sharing is caring for developmental psychology
Authors: Veldkamp Coosje Lisabet Sterre , Kemner Chantal 
Published: June 2023

AbstractMany of us, especially in the more experimental tradition, are used to doing it all ourselves: we don't know better than to collect our own data for every new study. We invest considerable amounts of time and resources in designing experiments, ethical review applications, participant recruitment, finding and training measuring assistants, and writing data management plans. And after all the hard work we end up with a sample size that hardly ever meets current standards. What if we could skip, or outsource some of these study aspects, allowing us to devote more of our time, energy, expertise, and experience to data analysis, reading, writing, and theory development? We argue that sharing data, expertise, and infrastructure could contribute to improving the credibility of research results, and to practicing more sustainable developmental science. In addition, we discuss several reasons that we believe may (currently) dissuade researchers from considering such sharing.
Diagnostic study of human papillomavirus DNA detection in cervical and vaginal samples using the filter paper card
Authors: Ramesan Chiyancheri Koroth , Calvin John Dickson , Thomas Anitha , Fletcher John , Kannangai Rajesh , Abraham Priya , Peedicayil Abraham 
Published: June 2023

AbstractObjectiveTo determine the accuracy of high‐risk human papillomavirus (HPV) DNA samples on filter paper in comparison to specimen transport medium (STM).MethodsThis was a cross‐sectional diagnostic study of 42 consecutive women who were prospectively recruited. Each had self‐collected vaginal samples on filter paper, physician‐collected cervical samples on filter paper, and physician‐collected cervical samples in STM. HPV DNA testing was performed with a Hybrid Capture 2 system (Qiagen). Sensitivity, specificity, negative predictive value (NPV), positive predictive value (PPV), and agreement of filter paper methods with the standard procedure were calculated.ResultsThe overall prevalence of HPV in STM was 67.5%. Detection of HPV DNA in the physician‐collected cervical samples on filter paper had a sensitivity of 77.8%, a specificity of 100%, a PPV of 100%, and an NPV of 68.4%. The patient's self‐sampling on filter paper had a sensitivity of 66.7%, a specificity of 100%, a PPV of 100%, and an NPV of 59.1%. The agreement between STM method and physician‐collected sample on filter paper was substantial, (κ = 0.695, P < 0.001), while the agreement between STM and self‐collected samples on filter paper was moderate (κ = 0.565, P < 0.001). Most patients reported that self‐collection was acceptable (100%), painless (95%), and not embarrassing (95%).ConclusionFilter paper, with dried self‐collected vaginal samples, can be used to detect high‐risk HPV with acceptable accuracy.
Obstetric and perinatal outcome in short‐stature patients
Authors: Leybovitz‐Haleluya Noa , Sheiner Eyal , Wainstock Tamar 
Published: June 2023

AbstractObjectiveScarce data exist regarding obstetric complications of short‐stature patients. This study aimed to investigate obstetric and perinatal outcomes in women with short stature; specifically, to investigate whether short‐stature patients are at an increased risk for cesarean delivery.MethodsA population‐based cohort study was conducted, including all singletons born between the years 1991 and 2021 at a tertiary medical center. Obstetric and perinatal outcomes of short‐stature patients were compared with those of non‐short patients. A generalized estimation equation binary logistic model was constructed to adjust for confounders and maternal recurrence in the cohort.ResultsThe study population included 356 356 parturient; among them, 14 035 (3.9%) were short‐stature patients. Short‐stature patients had significantly higher rates of cesarean delivery (20.7% vs 13.7%, odds ratio = 1.64, 95% confidence interval 1.57–1.71, P < 0.001), induction of labor, pathologic presentations, prolonged second stage of labor, non‐reassuring fetal monitoring, and meconium‐stained amniotic fluid. Newborns of short‐stature patients had a significantly higher risk of being small for gestational age as compared with those of non‐short patients. In the generalized estimation equation models, the association between short stature and risk of cesarean delivery remained significant (adjusted odds ratio = 1.32, 95% confidence interval 1.27–1.38, P < 0.001), as well as the risk of small for gestational age newborns (adjusted odds ratio = 1.51, 95% confidence interval 1.40–1.63, P < 0.001), but not for the other adverse outcomes.ConclusionsMaternal short stature is an independent risk factor for cesarean delivery and is associated with small for gestational age newborns.
Polarization coherency matrix tomography
Authors: He Youwu , Li Ke , Li Wangbiao , Qiu Yishen , Li Dezi , Wang Chen , Tang Qinggong , Li Zhifang 
Published: June 2023

AbstractIn this paper, a polarization‐sensitive optical coherence tomography (PS‐OCT) based polarization coherency matrix tomography (PCMT) combining polarization coherency matrix with Mueller matrix is proposed for the determination of complete polarization properties of tissue. PCMT measures the Jones matrix of biological sample based on similar transformation, in which four elements have initial random phase from different polarization states based on traditional PS‐OCT. The results indicate that PCMT can eliminate the phase difference of incident lights with different polarization states. In addition, the polarization coherency matrix using three polarization states has complete information of the sample Jones matrix. Finally, the 16 elements of the sample Mueller matrix are applied for deriving fully polarized optical properties of the sample based on the elliptical diattenuator and the elliptical retarder. Thus, the method based on the PCM and Mueller matrix has the advantage over the traditional PS‐OCT.
An overview of programmed cell death: Apoptosis and pyroptosis—Mechanisms, differences, and significance in organism physiology and pathophysiology
Authors: Kowalski Szymon , Karska Julia , Łapińska Zofia , Hetnał Bartosz , Saczko Jolanta , Kulbacka Julita 
Published: June 2023

AbstractRegulated cell death is an essential and heterogeneous process occurring in the life cycle of organisms, from embryonic development and aging to the regulation of homeostasis and organ maintenance. Under this term, we can distinguish many distinct pathways, including apoptosis and pyroptosis. Recently, there has been an increasing comprehension of the mechanisms governing these phenomena and their characteristic features. The coexistence of different types of cell death and the differences and similarities between them has been the subject of many studies. This review aims to present the latest literature in the field of pyroptosis and apoptosis and compare their molecular pathway's elements and significance in the physiology and pathophysiology of the organism.
miR‐210/NF‐κB axis: A new direction for regulating cadmium‐induced pig artery inflammatory injury
Authors: Zhang Yiming , Liu Qiaohan , Wu Hao , Du Yongzhen , Wang Xixi , Xu Shiwen 
Published: June 2023

AbstractCadmium (Cd) is a toxic metal pollutant that still exists in the environment. The microRNA (miRNA) is a type of noncoding RNA that plays an important role in gene posttranscriptional regulation and disease development. Although the toxic effects of Cd have been extensively studied, studies on the mechanism of Cd from the perspective of miRNA are still limited. So, we established a Cd‐exposure pig model, which confirmed that Cd exposure would cause pig artery damage. The miR‐210 with the most reduced expression and the nuclear factor kappa B (NF‐κB) that had a targeting relationship with miR‐210 were screened. The effect of miR‐210/NF‐κB on the artery damage induced by Cd exposure was investigated by acridine orange/ethidium bromide staining, reactive oxygen species (ROS) staining, quantitative PCR, and western blotting. The results showed that miR‐210 inhibitor, pcDNA‐NF‐κB could induce ROS overproduction in pig hip artery endothelial cells, thus inducing Th1/Th2 imbalance and necroptosis, leading to increased inflammation, while small interfering RNA‐NF‐κB played a mitigating role. In conclusion, Cd can induce artery necroptosis and Th1/Th2 imbalance by regulating the miR‐210/NF‐κB axis, so as to lead to artery inflammatory damage. In this study, we explored the way in which Cd exposure causes artery damage in pig, providing a new perspective on the regulatory damage of miR‐210/NF‐κB axis.
MitoNEET prevents iron overload‐induced insulin resistance in H9c2 cells through regulation of mitochondrial iron
Authors: Tam Eddie , Sung Hye K. , Sweeney Gary 
Published: June 2023

AbstractIron overload (IO) induces insulin resistance in H9c2 cardiomyoblast cells. Here, we used H9c2 cells overexpressing MitoNEET to examine the potential for protection against iron accumulation in the mitochondria and subsequent insulin resistance. In control H9c2 cells, IO was observed to increase mitochondrial iron content, reactive oxygen species (ROS) production, mitochondrial fission, and reduced insulin‐stimulated Akt and ERK1/2 phosphorylation. IO did not significantly affect mitophagy, or mitochondrial content, however, an increase in peroxisome‐proliferator‐activated receptor gamma coactivator 1 alpha (PGC1α) protein expression, a key regulator of mitochondrial biogenesis, was observed. MitoNEET overexpression was able to attenuate the effects of IO on mitochondrial iron content, reactive oxygen species, mitochondrial fission, and insulin signaling. MitoNEET overexpression also upregulated levels of PGC1α protein. The mitochondria‐targeted antioxidant, Skq1, prevented IO‐induced ROS production and insulin resistance in control cells, indicating mitochondrial ROS plays a causal role in the onset of insulin resistance. The selective mitochondrial fission inhibitor, Mdivi‐1, prevented IO‐induced mitochondrial fission, however, it did not alleviate IO‐induced insulin resistance. Collectively, IO causes insulin resistance in H9c2 cardiomyoblasts and this can be averted by reduction of mitochondrial iron accumulation and ROS production by overexpression of the MitoNEET protein.
The suppression of hyperlipid diet‐induced ferroptosis of vascular smooth muscle cells protests against atherosclerosis independent of p53/SCL7A11/GPX4 axis
Authors: You Jia , Ouyang Siyu , Xie Zhongcheng , Zhi Chenxi , Yu Jiang , Tan Xiaoqian , Li Pin , Lin Xiaoyan , Ma Wentao , Liu Zhiyang , Hou Qin , Xie Nan , Peng Tianhong , Chen Xi , Li Liang , Xie Wei 
Published: June 2023

AbstractFerroptosis as a novel programmed cell death that involves metabolic dysfunction due to iron‐dependent excessive lipid peroxidation has been implicated in atherosclerosis (AS) development characterized by disrupted lipid metabolism, but the atherogenic role of ferroptosis in vascular smooth muscle cells (VSMCs), which are principal components of atherosclerotic plaque fibrous cap, remains unclear. The aim of this study was to determine the effects of ferroptosis on AS induced by lipid overload, and the effects of that on VSMCs ferroptosis. We found intraperitoneal injection of Fer‐1, a ferroptosis inhibitor, ameliorated obviously high‐fat diet‐induced high plasma levels of triglycerides, total cholesterol, low‐density lipoprotein, glucose and atherosclerotic lesions in ApoE−/− mice. Moreover, in vivo and in vitro, Fer‐1 reduced the iron accumulation of atherosclerotic lesions through affecting the expression of TFR1, FTH, and FTL in VSMCs. Interestingly, Fer‐1 did augment nuclear factor E2‐related factor 2/ferroptosis suppressor protein 1 to enhance endogenous resistance to lipid peroxidation, but not classic p53/SCL7A11/GPX4. Those observations indicated inhibition of VSMCs ferroptosis can improve AS lesions independent of p53/SLC7A11/GPX4, which preliminarily revealed the potential mechanism of ferroptosis in aortic VSMCs on AS and provided new therapeutic strategies and targets for AS.
Administration of agmatine prior to physical or psychological stress in pregnant mice ameliorates behavioural and cognitive deficits in female offspring
Authors: Hassanshahi Amin , Janahmadi Mahyar , Razavinasab Moazamehosadat , Ilaghi Mehran , Kohlmeier Kristi A. , Hassanshahi Elham , Shabani Mohammad 
Published: June 2023

AbstractPhysical or psychological stress experienced by a mother during gestation is often associated with serious behavioural and cognitive deficits in newborns. Investigations of protective agents, which could prevent the adverse outcomes of prenatal stress (PS), are warranted. Agmatine is a neurotransmitter putatively involved in the physiological response to stress, and exogenous administration of agmatine has been shown to produce a variety of neuroprotective effects. In this study, we aimed to assess whether prenatal agmatine exposure could ameliorate behavioural and cognitive deficits in female offspring born to prenatally stressed mice. Pregnant Swiss Webster (SW) mice were exposed to physical or psychological stress from the 11th to 17th days of gestation. Agmatine (37.5 mg/kg, i.p.) was administrated 30 min before the induction of stress for seven consecutive days. The pups were assessed using a variety of behavioural tests and molecular assays on postnatal days 40 to 47. Agmatine attenuated impairments in locomotor activity, anxiety‐like behaviour, and drug‐seeking behaviour associated with both physical and psychological PS. Furthermore, agmatine reduced PS‐induced impairments in passive avoidance memory and learning. Neither PS nor agmatine treatment affected the mRNA expression level of hippocampal brain‐derived neurotrophic factor (BDNF) or tyrosine hydroxylase (TH) in the ventral tegmental area (VTA). Taken together, our findings highlight the protective effects of prenatally administered agmatine on PS‐mediated behavioural and cognitive deficits of the offspring. Future studies are needed to elucidate the underlying mechanisms, which could allow for more targeted prenatal treatments.
Hypomagnesemia because of nedaplatin for cervical cancer: A case report
Authors: Komoda Jun , Hori Tetsuya , Sato Kotaro , Kusajima Kunio , Shimizu Taro 
Published: June 2023

AbstractA 76‐year‐old woman with cervical cancer was treated with nedaplatin, a platinum‐based drug. After the initiation of the treatment, she became aware of numbness, dizziness, and loss of appetite. Exploration of the causes revealed no clues, but blood tests revealed hypocalcemia and hypomagnesemia. She was treated with intravenous calcium and magnesium, which resolved calcium, magnesium levels, and her symptoms. She was diagnosed with hypomagnesemia because of nedaplatin. Regular follow‐up is necessary for patients during or after nedaplatin. Awareness of electrolyte disturbances may elucidate the accurate diagnosis even in patients with obscure symptoms, particular in undergoing or following anticancer therapies.
A compact 9–23 GHzlow noise amplifier with bandwidth extension techniques in 0.18‐μmSiGe BiCMOS
Authors: Luo Jiang , Chen Pengwei 
Published: June 2023

AbstractIn this paper, a novel wideband low noise amplifier (LNA) operating in the 9–23 GHz frequency range is presented. The proposed LNA design utilizes a combination technique consisting of pole‐tuning technique, shunt resistive‐capacitor negative feedback, and gate‐capacitive peaking technique to achieve significant bandwidth extension while maintaining acceptable overall performance. For verification, a one‐stage triple‐stacked LNA using the combination technique is designed and implemented in a 0.18‐μm SiGe BiCMOS heterojunction bipolar transistor (HBT) process. The fabricated prototype demonstrates a peak gain of 13.8 dB at 19.5 GHz, minimum noise figure of 3.1 dB at 14 GHz, 3‐dB bandwidth of 14 GHz, and a fractional bandwidth of 87.5%, while consuming a dc power of 39.6 mW. Moreover, the chip occupies a small silicon area of 0.39 mm2including all testing pads with a core size of only 0.192 mm2.
Training Requirements in Point‐of‐Care Ultrasonography of the Upper Airway: A Feasibility Study
Authors: Karakosta Agathi , Pantazi Danai , Margariti Persefoni , Micha Georgia , Samara Evangelia , Tzimas Petros 
Published: June 2023

ObjectivesPoint‐of‐care ultrasonography of the upper airway can be a useful supplement to conventional pre‐anesthetic clinical evaluations. However, the reliability of such examinations is highly operator‐dependent and proper training in sonoanatomy and ultrasound operational skills are required. The objective of this study aims to assess the minimum training requirements for applying a predefined upper airway scanning protocol in healthy volunteers by anesthesia trainees.MethodsTwenty‐two healthy volunteer members of the Operating Room staff participated in the study. A predefined scanning protocol that included the identification of specific structures (hyoid bone, vocal cords, thyrohyoid membrane/epiglottis/pre‐epiglottic space, cricothyroid membrane, and thyroid gland), as well as the performance of specific measurements (distance from the hyoid bone to skin, anterior commissure to skin, epiglottis to skin, and thyroid isthmus to skin) was taught in a single‐day training course. The trainees' competence was assessed after multiple scanning repetitions performed over a week. Mixed effects regression models were applied for the trainee–instructor differences in all ultrasound measurements.ResultsCricothyroid membrane visualization had the lowest success rate (88%). Trainee–instructor differences were statistically significant for hyoid bone‐to‐skin (P < .001) and epiglottis‐to‐skin distances (P = .016). Measurement of the distance from the epiglottis to the skin required more scanning repetitions to achieve minimum deviance compared with other measurements. Ten or fewer scanning repetitions were sufficient to achieve minimum deviance for all four measurements.ConclusionsAt least 10 scanning repetitions of a pre‐defined upper airway scanning protocol can be used as the minimum standard for training.
Beyond Early Development: Observing Zebrafish over 6 Weeks with Hybrid Optical and Optoacoustic Imaging
Authors: Vetschera Paul , Koberstein‐Schwarz Benno , Schmitt‐Manderbach Tobias , Dietrich Christian , Hellmich Wibke , Chekkoury Andrei , Symvoulidis Panagiotis , Reber Josefine , Westmeyer Gil , López‐Schier Hernán , Omar Murad , Ntziachristos Vasilis 
Published: June 2023

AbstractZebrafish are common model organisms in developmental biology, but have recently emerged as imaging targets of research in cancer, tissue regeneration, metabolic disorders, functional genomics, and phenotype‐based drug discovery. Conventionally, zebrafish are studied during the first few days of development using optical microscopy methods. However, optical methods are not suited for imaging at later stages, since the fish become opaque. To address needs to visualize beyond the first days of development, a novel multimodality system for observing zebrafish from larval stage to adulthood is developed. Using a hybrid platform for concurrent selective plane illumination microscopy (SPIM) and optoacoustic mesoscopy, fish (ex vivo) at stages of development up to 47 days at a similar object size‐to‐resolution ratio are imaged. Using multiple wavelength illumination over the visible and short‐wavelength infrared regions, it is demonstrated that the optoacoustic method can follow GFP‐based contrast used in SPIM, enabling molecular imaging interrogation in adult fish. Moreover, the optoacoustic modality reveals zebrafish features based on optical contrast absent in SPIM, including contrast from endogenous blood, water, and lipids. It is discussed how the hybrid system method can enable the study of zebrafish in a wider range of applications and over time‐scales not possible currently when using optical microscopy.
Beam Self‐Cleaning of 1.5 μ$\umu$m High Peak‐Power Spatiotemporal Mode‐Locked Lasers Enabled By Nonlinear Compression and Disorder
Authors: Fu Guohao , Qi Tiancheng , Yu Weilong , Wang Lele , Wu Yulun , Pan Xiuyuan , Xiao Qirong , Li Dan , Gong Mali , Yan Ping 
Published: June 2023

AbstractThe realization of beam self‐cleaning in a cavity is more challenging than in the outside cavity. The peak power of intracavity pulses needs to be high to reach the threshold of beam self‐cleaning, which usually relies on additional diffraction grating to compress pulses in a positive‐dispersion cavity. Here, it is first experimentally and numerically demonstrated that self‐cleaning can be observed in an all‐fiber high peak‐power Er‐doped spatiotemporal mode‐locked (STML) laser at all‐negative‐dispersion. Through the nonlinear compression of graded‐index multimode fiber, the pulses are compressed along with the emergence of beam self‐cleaning. Besides, the inherent disorder of multimode fiber accelerates the self‐cleaning process. The intracavity pulse energy of ≈13 nJ with a pulse duration of 734.5 fs is derived under a highly multimode excitation, with an output pulse energy of 2.33 nJ. The pulse energy is a nearly fourfold improvement over the previous report in all‐fiber STML at 1.5 m. Temporal‐dependent characteristics and nonlinear polarization dynamics of beam self‐cleaning are also experimentally uncovered. It is demonstrated that the STML fiber laser will enable new insights into nonlinear pulse propagation in cavities and related applications.
The Role of Mechanical Properties and Structure of Type I Collagen Hydrogels on Colorectal Cancer Cell Migration
Authors: Castro‐Abril Hector , Heras Jónathan , del Barrio Jesús , Paz Laura , Alcaine Clara , Aliácar Marina Pérez , Garzón‐Alvarado Diego , Doblaré Manuel , Ochoa Ignacio 
Published: June 2023

AbstractMechanical interactions between cells and their microenvironment play an important role in determining cell fate, which is particularly relevant in metastasis, a process where cells invade tissue matrices with different mechanical properties. In vitro, type I collagen hydrogels have been commonly used for modeling the microenvironment due to its ubiquity in the human body. In this work, the combined influence of the stiffness of these hydrogels and their ultrastructure on the migration patterns of HCT‐116 and HT‐29 spheroids are analyzed. For this, six different types of pure type I collagen hydrogels by changing the collagen concentration and the gelation temperature are prepared. The stiffness of each sample is measured and its ultrastructure is characterized. Cell migration studies are then performed by seeding the spheroids in three different spatial conditions. It is shown that changes in the aforementioned parameters lead to differences in the mechanical stiffness of the matrices as well as the ultrastructure. These differences, in turn, lead to distinct cell migration patterns of HCT‐116 and HT‐29 spheroids in either of the spatial conditions tested. Based on these results, it is concluded that the stiffness and the ultrastructural organization of the matrix can actively modulate cell migration behavior in colorectal cancer spheroids.