bluuebunny/crossref_metadata_2025_split huggingface dataset:
The HP1γ epigenetic silencer dampens IFN-γ response at the gut epithelial barrier
Authors: Xiang Yao , Mata-Garrido Jorge , desterke Christophe , Batsché Eric , Hamaï Ahmed , Sereme Youssouf , Skurnik David , Jalil Abdelali , Beche Jean-Christophe , Piaggio Eliane , Arbibe Laurence , Chang Yunhua 
Published: December 2022

AbstractInterferon gamma (IFN-γ) plays central roles in the pathophysiology of inflammatory bowel disease (IBD), both activating inflammatory responses and immunosuppressive functions. However, the epigenetic mechanisms controlling the expression of IFN-γ responsive genes at the gut epithelial barrier are not well understood. In this study, we identified the epigenetic regulator HP1γ as a transcriptional repressor of the IFN-γ-responsive genes STAT1 (signal transducer and activator of transcription 1) and PD-L1 (Programmed Cell Death Ligand 1). Accordingly, HP1γ gene inactivation in the mouse gut epithelium resulted in an immunopathology with a long-lasting up-regulation of STAT1 and PD-L1.Colon organoids models and in vitrocell lines showed that HP1γ deficiency primed STAT1 and PD-L1 expressions, ultimately sensitizing epithelial cells to IFN-γ stimulation. Chromatin immunoprecipitation experiments suggest that HP1 promoter tethering is involved in the silencing of gene expression. Overall, these results identify HP1γ as an epigenetic silencing pathway controlling the IFN-γ response at the epithelial barrier.
Simulating and optimizing precast wall lifting in prefabricated building construction
Authors: Yuan Zhenmin , Chang Yuan , Chen Yunfeng , Wang Yaowu , Huang Wei , Chen Chen 
Published: December 2022

PurposePrecast wall lifting during prefabricated building construction faces multiple non-lean problems, such as inaccurate lifting-time estimation, unreasonable resource allocation and improper process design. This study aims to identify the pathways for improving lifting performance to advance lean construction of prefabricated buildings.Design/methodology/approachThis study developed a methodological framework that integrates the discrete event simulation method, the elimination, combination, rearrangement and simplification (ECRS) technique and intelligent optimization tool. Two schemes of precast wall lifting, namely, the enterprise's business as usual (BAU) and enterprise-leading (EL) schemes, were set to benchmark lifting performance. Furthermore, a best-practice (BP) scheme was modeled from the perspective of lifting activity ECRS and resource allocation for performance optimization.FindingsA real project was selected to test the effect of the methodological framework. The results showed that compared with the EL scheme, the BP scheme reduced the total lifting time (TLT) by 6.3% and mitigated the TLT uncertainty (the gap between the maximum and minimum time values) by 20.6%. Under the BP scheme, increasing the resource inputs produces an insignificant effect in reducing TLT, i.e. increasing the number of component operators in the caulking subprocess from one to two only shortened the TLT by 3.6%, and no further time reduction was achieved as more component operators were added.Originality/valueTo solve non-lean problems associated with prefabricated building construction, this study provides a methodological framework that can separate a typical precast wall lifting process into fine-level activities. Besides, it also identifies the pathways (including the learning effect mitigation, labor and machinery resource adjustment and activities’ improvement) to reducing TLT and its uncertainty.
The role of an open analytics culture and analytics skills in adopting real-time supply chain analytics for higher performance
Authors: Oliveira Marcos Paulo Valadares de , Handfield Robert 
Published: December 2022

PurposeThe study objective was to understand what components of organizational culture and capability combined with analytic skillsets are needed to allow organizations to exploit real-time analytic technologies to create supply chain performance improvements.Design/methodology/approachThe authors relied on information processing theory to support a hypothesized model, which is empirically tested using an ordinary least squares equation model, and survey data from a sample of 208 supply chain executives across multiple industries.FindingsThe authors found strong support for the concept that real-time analytics will require specialized analytical skills for the managers who use them in their daily work, as well as an analytics-focused organizational culture that promotes data visibility and fact-based decision-making.Practical implicationsBased on the study model, the authors found that a cultural bias to embrace analytics and a strong background in statistical fluency can produce decision-makers who can make sense of a sea of data, and derive significant supply chain performance improvements.Originality/valueThe research was initiated through five workshops and presentations with supply chain executives leading real-time analytics initiatives within their organizations, which were then mapped onto survey items and tested. The authors complement our findings with direct observations from managers that lend unique insights into the field.
Dynamic trade and technology linkages: a perspective from global value chain upgradation of Asian countries
Authors: Arora Kashika , Siddique Areej Aftab 
Published: December 2022

PurposeThe focus is on determining the long-term relationship in explaining how technological capabilities interact with trade and global value chain (GVC) participation to aid in the upgradation process using a panel auto-regressive distributed lag (ARDL) model. The results suggest that export of both low-skill and medium-skill technology-intensive manufactures and patents by residents positively and significantly impact GVC participation.Design/methodology/approachThis paper examines the dynamic linkages between GVC participation and technological capability of major Asian countries in a comparative (1995–2018) perspective.FindingsThis implies that certain sectors enable greater integration into GVCs in the long-run, supported by critical learning variables. Further, with the help of the panel causality test, a bi-directional flow between GVC participation and export of high-technology manufactures and import of labour-intensive technology manufactures is witnessed. Even a one-way flow from research and development (R&D) intensity to GVC participation is seen.Originality/valueThe technological capabilities are found to be characterising the initial structure of local enterprises in trade and GVCs, as well as the extent to which emerging-market firms may harness knowledge flows and migrate into high-tech industries.
When will consumers splurge on travel? Effective add-on selling strategies
Authors: Kim Esther L. , Tanford Sarah 
Published: December 2022

PurposeCross-selling becomes critical for business success as pent-up travel demand drives travelers to spend more on vacations. The primary purpose of this research is to identify if an unexpected discount leads to consumers' additional purchases online. This research proposes effective cross-selling strategies across hospitality sectors.Design/methodology/approachTwo experiments were conducted to investigate factors that influence travelers' add-on spending. Study 1 determined the psychological mechanism of unexpected discounts on hotel customers' additional spending by individual thinking styles. A 2 (discount: none vs surprise) x 2 (thinking style: holistic vs analytic) quasi-experimental design was utilized. Study 2 applied the identified pricing strategy by individual thinking styles to cruise line add-on selling. A 2 (discount: none vs surprise) x 2 (product type: hedonic vs utilitarian) x 2 thinking style (holistic vs analytic) quasi-experiment was used.FindingsThe findings indicate that an unexpected discount increases holistic thinkers' overall travel spending, regardless of add-on types. Although the unexpected discount effect on analytic thinkers' overall spending was significant, an unexpected discount enhanced their intentions to purchase a hedonic add-on.Practical implicationsHospitality operators can improve cross-selling strategies with a surprise discount offer. Offering add-on items in the same transaction with a cabin booking will increase add-on purchases. Hotels can make add-on purchases more appealing by emphasizing the experiential aspects of a hotel stay.Originality/valueThis research broadens knowledge of cross-selling by linking add-on purchases to discount pricing on a primary product. The findings provide new strategies to stimulate add-on purchases and maximize profitability.
Boosting advice and knowledge sharing among healthcare professionals
Authors: Fronzetti Colladon Andrea , Grippa Francesca , Broccatelli Chiara , Mauren Cynthia , Mckinsey Scarlett , Kattan Jacob , Sutton Evelyne St. John , Satlin Lisa , Bucuvalas John 
Published: December 2022

Purpose
This study aims to investigate the dynamics of knowledge sharing in health care, exploring some of the factors that are more likely to influence the evolution of idea sharing and advice seeking in health care.

Design/methodology/approach
The authors engaged 50 pediatricians representing many subspecialties at a mid-size US children’s hospital using a social network survey to map and measure advice seeking and idea sharing networks. Through the application of Stochastic Actor-Oriented Models, the authors compared the structure of the two networks prior to a leadership program and eight weeks post conclusion.

Findings
The models indicate that health-care professionals carefully and intentionally choose with whom they share ideas and from whom to seek advice. The process is fluid, non-hierarchical and open to changing partners. Significant transitivity effects indicate that the processes of knowledge sharing can be supported by mediation and brokerage.

Originality/value
Hospital administrators can use this method to assess knowledge-sharing dynamics, design and evaluate professional development initiatives and promote new organizational structures that break down communication silos. This work contributes to the literature on knowledge sharing in health care by adopting a social network approach, going beyond the dyadic level and assessing the indirect influence of peers’ relationships on individual networks.
Impact of diversity management on innovative work behavior: mediating role of human resource management and affective commitment
Authors: Tajeddini Kayhan , Budur Taylan , Gamage Thilini Chathurika , Demir Ahmet , Zaim Halil , Topal Ramazan 
Published: December 2022

PurposeThis paper investigates the effect of diversity management on employees' innovative work behavior (IWB) through human resource management (HRM) and affective commitment (AC).Design/methodology/approachData were collected from 358 employees of small- and medium-sized enterprises in the Kurdistan Region of Iraq. The hypothesized model has been evaluated using structural equation modeling.FindingsFindings suggest that workforce diversity management directly and significantly affected HRM and AC. Furthermore, findings revealed that HRM significantly influenced both employees' IWB and AC, while AC had a significant positive influence on IWB. Moreover, concerning the indirect effects, AC and HRM significantly mediated the relationship between DM and employees' IWB.Research limitations/implicationsA cross-sectional single source dataset is used to evaluate the hypothesized model.Originality/valueGrounded in the social exchange and institutional theories, this research fills the gap in the literature by addressing the “black box” of how workforce DM influences employees' IWB while examining the mediating role of employees' AC and firm HRM policies.
Synthesis, optical properties and DFT-TDDFT computational study of phenothiazine dye: donor-acceptor molecules
Authors: A.M. Al-Zahrani Fatimah 
Published: December 2022

Purpose
The purpose of this study aims to synthesize a novel donor–acceptor dye based on phenothiazine as a donor (D) and nonconjugated spacer was devised and synthesized by condensing of 2,2'-(1H-indene-1,3(2H)-diylidene) dimalononitrile with aldehyde and the practical synthesis methodology as given in Scheme 1.

Design/methodology/approach
The prepared phenothiazine dye was systematically experimentally and theoretically examined and characterized using nuclear magnetic resonance spectroscopy (1H,13C NMR), Fourier-transform infrared spectroscopy (IR) and high-resolution mass spectrometry. Density functional theory (DFT) and time-dependent density functional theory DT-DFT calculations were implemented to determine the electronic properties of the new dye

Findings
The UV-Vis absorption and fluorescence spectroscopy of the synthesized dye was investigated in a variety of solvents with varying polarities to demonstrate positive solvatochromism correlated with intramolecular charge transfer (ICT). The probe’s quantum yields (Фf) are experimentally measured in ethanol, and the Stokes shifts are found to be in the 4846–9430 cm−1 range.

Originality/value
The findings depicted that the novel (D-π-A) chromophores may act as a significant factor in the organic optoelectronics.
Free water input into the New Britain subduction zone in Solomon Sea estimated from reflected seismic data
Authors: Deyong Li , Yu Huang , Xiaodian Jiang , Wei Gong , Enjiang Wang , Honggang Cheng 
Published: December 2022

AbstractIt is of great significance to examine the distribution of the fluid within the subduction zone to estimate the water flux into the subduction zone and to study the motion state of the subducting plate. The interaction of the Western Pacific Plate and the Indo‐Australian Plate controls the subduction and expansion of the Solomon Basin where the mechanisms governing plate activity remain unclear but are typically associated with high pore fluid pressures and stabilizing frictional conditions. Combining the long streamer seismic data (200) and nine well logs inside the work area, we used constrained sparse spike inversion to obtain the P‐wave impedance profile. Then we constructed reservoir rock physics models to predict the fluids distribution in New Britain Trench subduction system in Solomon Sea. The genetic algorithm was used to guide the inversion of the pore fluid distribution. The water content profile revealed the shallow structure of the New Britain Trench subduction system in Solomon Sea, including the water content within the basalt layers. We determined that in certain cases, faults identified from the reflection data were associated with low‐impedance anomalies, and this may indicate that they are zones of high porosity that act as conduits for fluid flow. The continuity of the distribution of water content under the New Britain Trench suggests that there is a large amount of free water that subducts deeply and may be important in controlling the motion state of the subducting plate. We assume that the water saturation is 1. Therefore, the free water flux entering the deep circle with the subducting plate is estimated to be 158 Tg/Ma/m totally, including 53.724 Tg/Ma/m in the sediment and 105.06 Tg/Ma/m in the basalt. This study provides insight into the structure of free water in the New Britain subduction zone and reveals the potential for the direct estimation of the 2D structural distribution of water content using geophysical survey data.
Evaluation of the antioxidant characteristics of craft beer with green tea
Authors: Yang Lixia , Lu Zhendong , Lu Jian , Wu Dianhui 
Published: December 2022

AbstractThe addition of green tea as antioxidants to beer can improve the beer's flavor stability by protecting against staling during storage. To analyze the effect of different green teas on the flavor stability of beer, we developed an approach to rapidly evaluate their antioxidant activity. Ten types of craft beer were produced by adding different kinds of green tea during brewing, and their antioxidant activity and phenolic profiles were evaluated. The results showed remarkable variations in antioxidant activity and antioxidative compound contents, which were considerably higher in green tea beers than in non‐tea beer (p < 0.05). A comprehensive evaluation function was developed to evaluate the total antioxidant activity of beers using principal component analysis. The highest total antioxidant activity was observed in Taiping Houkui beer, with a comprehensive evaluation score of 2.53. Pearson correlation analysis suggested that (−)‐epigallocatechin gallate, (−)‐epicatechin gallate, and (−)‐epigallocatechin were strongly correlated with the total antioxidant activity of green tea beers (p < 0.01). The summation of their contents represented more than 60% of the total phenolic content of the teas, which can be used to predict the total antioxidant activity of green tea beers.Practical ApplicationFlavor stability is of prime concern for brewers, and flavor aging is increasingly becoming the limiting factor in beer shelf life. The application of green tea as antioxidants in beer can improve the flavor stability by protecting against beer staling during storage. The analytical method developed in this study will contribute to the rapid comparison of the effect of different green teas on the flavor stability of beer. Furthermore, the research findings demonstrate the potential benefits of green teas to beer flavor stability, which is of considerable importance in promoting the development and consumption of green teas.
Novel dimensionless index for physically based assessment of thermal refugia characterizes off‐channel habitat on gravel bed river
Authors: Gombert Carolyn E. , Lancaster Stephen T. , Grant Gordon E. , Flitcroft Rebecca L. 
Published: December 2022

AbstractIn the Willamette River, OR, main channel temperatures can be too warm for cold water fishes, causing fish to concentrate in secondary channel features that provide thermal refugia. However, temperature regimes vary among and within features. Improved understanding of physical processes controlling thermal regimes is needed. This study developed a dimensionless index for assessment of thermal refugia on the upper Willamette River. The novel hyporheic insolation (HIN) index uses minimal field measurements to predict thermal refugia resulting from buffering. Continuous water temperature measurements at one side channel, eight alcoves, and six beaver ponds provided data to ground truth calculated predictions. Water temperature records were first used to characterize stratification at sites. Calculation of the Richardson number, an index of stability, showed two well‐mixed sites and 13 stratified sites. At stratified sites, calculated values characterized the ratio of cooling flux from hyporheic discharge to heat flux from incoming solar radiation. As increased, measured temperatures at sites decreased. Despite overall scatter, a logarithmic fit to bin‐averaged values showed R2 = 0.91. Calculations suggest that secondary channel features characterized by stratification and cool hyporheic discharge can provide thermal refugia. Accordingly, the HIN index may serve as a practical tool grounded in physical processes governing temperature across a floodplain.
Timing of minor and major amputation in patients with diabetes‐related foot ulceration admitted to two public tertiary referral hospitals in Australia
Authors: Manewell Sarah M. , Aitken Sarah J. , Nube Vanessa L. , Crawford Anna M. , Constantino Maria I. , Twigg Stephen M. , Menz Hylton B. , Sherrington Catherine , Paul Serene S. 
Published: December 2022

AbstractBackgroundThere is limited information regarding the number of patients with diabetes‐related foot ulceration (DFU) who receive minor or major amputation, and how quickly these amputations occur. This study aimed to identify the incidence of index minor and major amputation among inpatients with DFU over 4 years, and where amputation occurred during the patient's index DFU‐related admission, investigate prognostic factors.MethodsThe incidence of index minor and major amputation, and the admission sequence during which amputation occurred were identified from DFU‐related admissions to two public hospitals during 2014–2018. Where minor or major amputation occurred during the patient's index DFU‐related admission, prognostic factors were investigated using logistic regression.ResultsDFU‐related hospital admissions were required by 564 patients. The incidence of minor amputation over 4 years was 34% (n = 193). The incidence of minor amputation during the patient's index DFU‐related admission was 28% (n = 155), which was associated with requiring revascularisation (odds ratio [OR] 2.33, 95% CI 1.53–3.55, P < 0.001). The incidence of major amputation over 4 years was 8% (n = 45). The incidence of major amputation during the patient's index DFU‐related admission was 6% (n = 31), which was associated with having more comorbidities (OR 1.58, 95% CI 1.10–2.26, P = 0.01) and receiving care for a mental health condition (OR 3.85, 95% CI 1.48–10.01, P = 0.006).ConclusionMost amputations occurred during the patient's index DFU‐related hospital admission. Major amputation during a patient's index admission was associated with more comorbidities and mental health conditions.
Cotard delusion in a depressed patient: “My throat is missing!”
Authors: Huan Wen Yi , Wan Azlan Wan Asyikin , Lee Yee Tieng 
Published: December 2022

AbstractCotard's syndrome is a rare neuropsychiatric disorder characterized by marked nihilistic delusions. This report describes an Indonesian woman from a small town in Malaysia who was diagnosed with depression and Cotard's delusion. The diagnosis was confirmed after thorough history‐taking, clinical examination, and relevant laboratory tests. Herein, we highlight the unique psychopathology of a possible Cotard's syndrome subtype and efficacy of pharmacological combination strategies, rather than monotherapy and electroconvulsive therapy, for its treatment.
Impact of the International Consensus Classification of myelodysplastic syndromes
Authors: Zhang Yudi , Wu Junying , Xu Zefeng , Qin Tiejun , Qu Shiqiang , Pan Lijuan , Wang Huijun , Sun Qi , Li Chengwen , Jia Yujiao , Cai Wenyu , Yan Xin , Gong Jingye , Gao Qingyan , Li Bing , Gale Robert Peter , Xiao Zhijian 
Published: December 2022

SummaryThe impact of the 2022 International Consensus Classification (ICC) of myelodysplastic syndromes (MDS) needs study. We analysed data from 989 MDS subjects classified using the 2016 World Health Organization (WHO) criteria to determine the impact of the new proposal. Our analyses suggested the ICC criteria of MDS‐SF3B1 identifies a more homogenous disease entity than the WHO 2016 criteria of myelodysplastic syndromes with ring sideroblasts (MDS‐RS). MDS, not otherwise specified with single lineage dysplasia (MDS, NOS‐SLD) patients had a better prognosis than MDS, NOS with multilineage dysplasia (MDS, NOS‐MLD) patients. MDS with mutated TP53 and MDS/acute myeloid leukaemia with mutated TP53 patients had the briefest survivals. These data support the ICC of MDS, which allows more accurate diagnoses and risk stratification.
Prec(ar)ious knowledge and the neoliberal academy: Towards re‐imagining epistemic justice and critical psychology
Authors: Fine Michelle 
Published: December 2022

AbstractThis epilogue is written in the ink of gratitude and provocation, reflecting on the essays that constitute the special issue on precarity. I briefly review the key gifts of the essays and then try to imagine how a social psychology of precarity could be theorized and engaged otherwise, with commitments to epistemic justice, designed with decolonizing methodologies and organized in solidarity with movements for social justice.