bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Impact of COVID-19 Pandemic on the Levels of Physical Activity: A Systematic Review
Authors: Mehraeen Esmaeil , Karimi Amirali , Mirghaderi Peyman , Mirzapour Pegah , Pashaei Zahra , Qaderi Kowsar , Afsahi Amir Masoud , Barzegary Alireza , Mohammadi Parsa , Shojaei Alireza , Saeidi Solmaz , Afroughi Fatemeh , MohsseniPour Mehrzad , Janfaza Nazanin , Dadras Omid , Amiri Ava , Azad Kimia , SeyedAlinaghi SeyedAhmad , Tantuoyir Marcarious Moorkereh , Voltarelli Fabricio 
Published: January 2023

Introduction:Earlier studies demonstrated a decreased level of physical activity (PA) during the COVID-19 pandemic. Therefore, we aimed to systematically review the relevant studies among various age groups and explore the impact on physical and mental health.Methods:We searched and retrieved all relevant articles using the keywords on the online databases of PubMed, Scopus, and Cochrane from the start of the pandemic until May 3rd, 2021. A two-phase screening process of identified records was carried out to shortlist the most relevant studies. First, the studies were evaluated based on their title/abstract, and then the full-text of included studies was thoroughly read. The eligible studies based on the eligibility criteria were included in this review.Results:A total of 57 studies were included based on the eligibility criteria. Lockdowns and infection with SARS-CoV-2 have led to a decreased level of PA in the general population compared to the prepandemic era. Men had significantly less PA compared to women in some studies, probably due to higher pre-pandemic PA. The level of PA among those with chronic diseases also significantly diminished, putting them at a higher risk of cardiovascular incidents. Sedentary lifestyles have dominated people’s life, including adolescents and university students. The increased levels of mental health issues, such as depression, anxiety, and occupational stress, have been suggested to contribute to the decreased PA. On the other hand, the decreased PA appeared to lead to more mental health issues. Fortunately, the decreasing trend of PA seemed to taper towards the end of the quarantines.Conclusion:Overall, the COVID-19 pandemic and subsequent quarantines reduced PA among all age groups and both sexes and had detrimental effects on people's physical and mental health. We suggest countries implement strategies to alleviate restrictions and encourage people to exercise in safe environments and prepare healthy routines for themselves.
Mechanisms Contributing to Acquired Activated Protein C Resistance in
Patients Treated with Thalidomide: A Molecular Dynamics Study
Authors: Maximiliano Correa Lara , Jaime García Chavez , Armando Vega Lopez , Vega Israel Lara , Victoria Hernandez Gonzalez , Erika Martinez Hernandez 
Published: January 2023

Introduction:
There is a high incidence of venous thromboembolism (VTE) in patients with Multiple Myeloma (MM), however; until now, the exact mechanisms behind VTE in MM are unknown, and some of the elements that may play a significant role are the treatment with an immunomodulator (IMiD) and acquired resistance to activated protein C (APC).

Objective:
The study aims to reveal the possible mechanisms linked to the reduced antithrombotic activity of APC associated with thalidomide.

Methods:
The molecular docking approach was used to ascertain the in silico inhibitory potential of thalidomide on the APC protease domain in the architecture of the catalytic triad and its interaction with major substrate binding sites.

Results:
The coupling showed that the inhibitory activity of thalidomide depends on the induction of structural changes in the protease domain of APC, at the level of the Ser/His/Asp catalytic triad, as a result of a significant increase between the distances of CαAsp102 and Cα Ser195 (11.175 angstroms, increase 14.83%) and between CαSer195 and CαHis57 (9.478 angstroms, increase 13.78 %). This can result in an inefficient transfer of the proton between these residues, the other possible mechanism of inhibition, is a potential reduced binding of the substrate as a result of a direct interaction through a carbon-hydrogen bond on His57, an H-bond on Arg306, and a carbon hydrogen bond on Arg506.

Conclusion:
We demonstrate the in silico inhibitory potential of thalidomide on APC, through two possible inhibition mechanisms, a pathophysiologically relevant finding to understand the factors that can affect the stability and functions of APC in vivo.
Effectiveness of Remote Fetal Monitoring on Maternal-Fetal Outcomes: Systematic Review and Meta-Analysis
Authors: Li Suya , Yang Qing , Niu Shuya , Liu Yu 
Published: January 2023

Background
To solve the disadvantages of traditional fetal monitoring such as time-consuming, cumbersome steps and low coverage, it is paramount to develop remote fetal monitoring. Remote fetal monitoring expands time and space, which is expected to popularize fetal monitoring in remote areas with the low availability of health services. Pregnant women can transmit fetal monitoring data from remote monitoring terminals to the central monitoring station so that doctors can interpret it remotely and detect fetal hypoxia in time. Fetal monitoring involving remote technology has also been carried out, but with some conflicting results.

Objective
The review aimed to (1) examine the efficacy of remote fetal monitoring in improving maternal-fetal outcomes and (2) identify research gaps in the field to make recommendations for future research.

Methods
We did a systematic literature search with PubMed, Cochrane Library, Web of Science, Embase, MEDLINE, CINAHL, ProQuest Dissertations and Theses Global, ClinicalTrials.gov, and Open Grey in March 2022. Randomized controlled trials or quasi-experimental trials of remote fetal monitoring were identified. Two reviewers independently searched articles, extracted data, and assessed each study. Primary outcomes (maternal-fetal outcomes) and secondary outcomes (health care usage) were presented as relative risks or mean difference. The review was registered on PROSPERO as CRD42020165038.

Results
Of the 9337 retrieved literature, 9 studies were included in the systematic review and meta-analysis (n=1128). Compared with a control group, remote fetal monitoring reduced the risk of neonatal asphyxia (risk ratio 0.66, 95% CI 0.45-0.97; P=.04), with a low heterogeneity of 24%. Other maternal-fetal outcomes did not differ significantly between remote fetal monitoring and routine fetal monitoring, such as cesarean section (P=.21; I2=0%), induced labor (P=.50; I2=0%), instrumental vaginal birth (P=.45; I2=0%), spontaneous delivery (P=.85; I2=0%), gestational weeks at delivery (P=.35; I2=0%), premature delivery (P=.47; I2=0%), and low birth weight (P=.71; I2=0%). Only 2 studies performed a cost analysis, stating that remote fetal monitoring can contribute to reductions in health care costs when compared with conventional care. In addition, remote fetal monitoring might affect the number of visits and duration in the hospital, but it was not possible to draw definite conclusions about the effects due to the limited number of studies.

Conclusions
Remote fetal monitoring seems to reduce the incidence of neonatal asphyxia and health care costs compared with routine fetal monitoring. To strengthen the claims on the efficacy of remote fetal monitoring, further well-designed studies are necessary, especially in high-risk pregnant women, such as pregnant women with diabetes, pregnant women with hypertension, and so forth.
Effectiveness of mHealth on Adherence to Antiretroviral Therapy in Patients Living With HIV: Meta-analysis of Randomized Controlled Trials
Authors: Sun Liang , Qu Mengbing , Chen Bing , Li Chuancang , Fan Haohao , Zhao Yang 
Published: January 2023

Background
The World Health Organization recommends that all adults with HIV adhere to antiretroviral therapy (ART). Good adherence to ART is beneficial to patients and the public. Furthermore, mHealth has shown promise in improving HIV medication adherence globally.

Objective
The aim of this meta-analysis is to analyze the effectiveness of mHealth on adherence to antiretroviral therapy in patients living with HIV.

Methods
Randomized controlled trials (RCTs) of the association between mHealth and adherence to ART published until December 2021 were searched in electronic databases. Odds ratios (ORs), weighted mean differences, and 95% CIs were calculated. This meta-analysis was performed using the Mantel-Haenszel method or the inverse variance test. We evaluated heterogeneity with the I2 statistic. If I2 was ≤50%, heterogeneity was absent, and a fixed effect model was used. If I2 was >50%, heterogeneity was present, and a random effects model was used.

Results
A total of 2163 participants in 8 studies were included in this meta-analysis. All included studies were RCTs. The random effects model was used for a meta-analysis of the effects of various intervention measures compared to routine nursing; the outcome was not statistically significant (OR 1.54, 95% CI 0.99-2.38; P=.05). In the subgroups, only short messaging service (SMS)-based interventions significantly increased adherence to ART (OR 1.76, 95% CI 1.07-2.89; P=.03). Further analysis showed that only interactive or bidirectional SMS could significantly increase ART adherence (OR 1.69, 95% CI 1.22-2.34; P=.001). After combining the difference in CD4 cell count before and after the interventions, we concluded that there was no statistical heterogeneity among the studies (I2=0%; tau2=0.37; P=.95).

Conclusions
Interactive or bidirectional SMS can enhance intervention effects. However, whether mHealth can improve adherence to ART in patients with HIV needs further study. Owing to a lack of the required significant staff time, training, and ongoing supervision, there is still much more to do to apply mHealth to the clinical use of ART for patients living with HIV.

Trial Registration
PROSPERO CRD42022358774; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=358774
Parent Experiences of Child Loss and End-of-Life Care in a Pediatric Intensive Care Unit: Protocol for a Qualitative Study
Authors: Alcón Nájera Sara , González-Gil Maria Teresa 
Published: January 2023

Background
Death of a child in the pediatric intensive care unit is a rare event that can occur after failed cardiopulmonary resuscitation efforts, after a brain death diagnosis, or after a decision to limit therapeutic efforts. Nevertheless, even in the case of children with terminal and progressive illnesses, death is a crisis that comes as a surprise to parents and is perceived as unexpected. In the final stage of a child’s life, health care staff play a key role in sharing feelings and experiences with the family and in supporting them throughout the process in order to facilitate the grieving process.

Objective
The aim of this study is to explore the experiences of parents whose children have died in a pediatric intensive care unit.

Methods
To address the study aims, a qualitative phenomenological study based on the van Manen proposal will be carried out. The study will be conducted in the pediatric intensive care unit of a tertiary care hospital. The study population will be parents or guardians (older than 18 years) of children who have died in the unit at least 6 months prior to potential participation in the study. Purposive sampling will be used to ensure sample diversity in relation to experiential variables. Families will be initially contacted by letter sent alongside the standard letter of condolences from the hospital, and then recruited in a subsequent telephone call. The sample size will be determined by data saturation. In-depth interviews will be conducted individually or in pairs. Parents will decide when, how, and where to conduct the interviews, which will be transcribed verbatim and examined using thematic discourse analysis.

Results
This study was awarded a grant in December 2020 and was approved by the Medical and Health Research Ethics Committee on December 21, 2020. Data collection started in April 2021, and the results are expected to be published in 2023.

Conclusions
This project is intended to maintain, strengthen, and build on a particular line of research on end-of-life care with a focus on effective coping, spiritual well-being, and the adaptive grieving process. The results will contribute to establishing action guidelines that are both based on the discourses of parents who have experienced the death of a child and geared toward high-quality end-of-life care through dignified death and adaptive grief management.

International Registered Report Identifier (IRRID)
DERR1-10.2196/43756
Efectividad de enjuagues bucales contra virus de la familia coronavirus
Authors: Álvarez- Ojeda Andrea , Lozada-Martínez Ariana , Pupo Marrugo Stella , Díaz-Caballero Antonio 
Published: January 2023

La aparición del virus Sars-CoV-2 y la enfermedad Covid-19 han provocado un estado de emergencia en el sistema de salud. Teniendo en cuenta el potencial de la saliva como material contaminante, la práctica odontológica fue una de las áreas que se vio afectada debido al uso de instrumentos que pueden esparcir aerosoles y salpicaduras que contienen microorganismos hacia el medio ambiente. Por esta razón, conociendo su potencial en la inactivación de patógenos, se propuso la utilización de enjuagues bucales en la práctica clínica previo a la realización de procedimientos dentales, sin embargo la evidencia no es clara respecto a su efectividad. Objetivo. Establecer el estado de evidencia actual del efecto de los enjuagues bucales sobre los coronavirus que se encuentran en cavidad. Métodos. Se realizó una revisión sistemática siguiendo todos los parámetros descritos en las DirectricesPRISMA basada en información obtenida en los buscadores Science direct, Pubmed y Dentistry and Oral Science Source. Los criterios de selección incluyeron estudios in vivo e in vitro de texto completo que evidenciaron la efectividad del enjuague bucal contra coronavirus. Resultados. Se obtuvieron 90 artículos, de los cuales sólo 12 cumplían con los criterios de inclusión,8 in vitro y 4 in vivo, que fueron sometidos a la evaluación de calidad metodológica utilizando la lista de verificación de evaluación crítica del JBI. Conclusiones. Los resultados sugieren que la povidona yodada es efectiva para la inactivación del virus Sars-coV-2 en todas sus concentraciones.
Funciones Ejecutivas en alta capacidad intelectual (ACI), trastorno por déficit de atención (TDAH), doble excepcionalidad (ACI-TDAH) e inteligencia promedio
Authors: Rodríguez Cervantes Celia Josefina , Valadez Sierra María De los Dolores , Verche Emilio , Soltero Avelar Rubén , González Betanzos Fabiola 
Published: January 2023

Introducción. Existe una marcada confusión diagnóstica entre Alta Capacidad Intelectual (ACI) y Trastorno por Déficit de Atención e Hiperactividad (TDAH), frecuentemente se han reportado características de comportamiento similares entre las poblaciones. Valorar Funciones Ejecutivas como procesos subyacentes puede aportar a un diagnóstico diferencial. El objetivo de este estudio es analizar las funciones ejecutivas de planificación, flexibilidad cognitiva, toma de decisión, memoria de trabajo, fluidez verbal, inhibición y atención en alumnos con ACI, alumnos con TDAH, alumnos con doble excepcionalidad (ACI-TDAH) y alumnos con inteligencia promedio, con el fin de establecer un perfil diferencial de estas poblaciones.
Método. Estudio cuantitativo, descriptivo y transversal ex post facto. Participaron 80 alumnos de educación básica de 7 a 10 años, distribuídos en cuatro grupos. Para la evaluación de las funciones ejecutivas se aplicó la Batería de Evaluación de Funciones Ejecutivas BANFE-2 y Conners Continuous Performance Test CPT-II. Los resultados se analizaron utilizando el Statistical Package for the Social Sciences SPSS v24. Se muestran datos descriptivos y análisis de Kruskal--Wallis para la diferencia de grupos.
Resultados. Las funciones flexibilidad cognitiva, fluidez verbal, memoria de trabajo verbal, inhibición y atención muestran algunas diferencias entre grupos obtenidas a través del análisis Kruskal-Wallis, sin observar una clara identificación de las poblaciones.
Discusión y conclusiones. Como conjunto, las funciones ejecutivas presentan mutivariabilidad, limitando la posibilidad de identificar a las poblaciones, por lo que resulta imprescindible considerar de manera específica las funciones ejecutivas en futuros trabajos.
Differences in Recovery of Tendon Health Explained by Midportion Achilles Tendinopathy Subgroups: A 6-Month Follow-up
Authors: Hanlon Shawn L. , Pohlig Ryan T. , Silbernagel Karin Grävare 
Published: January 2023

OBJECTIVES: To (1) evaluate whether the defining characteristics of previously reported Achilles tendinopathy subgroups were reproducible in a cohort with midportion Achilles tendinopathy and (2) compare recovery trajectories and outcomes. DESIGN: Prospective single cohort study. METHODS: Participants (n = 114; 57 women; age [mean ± standard deviation]: 47 ± 12 years) received the Silbernagel protocol and were evaluated at baseline, and at 8, 16, and 24 weeks. Subgroups were identified using mixture modeling. Main effects of group and time, and interaction effects were evaluated using linear mixed models for 23 outcome measures representing symptoms, lower extremity function, tendon structure, psychological factors, and patient-related factors. Recovery trajectories were reported descriptively to reflect clinically meaningful change for outcomes. RESULTS: Activity-Dominant (n = 34), Function-Dominant (n = 38), Psychosocial-Dominant (n = 27), and Structure-Dominant (n = 15) subgroups were identified. There were significant effects of group and time for all primary outcome measures, except heel-rise and viscosity limb symmetry indexes. The Activity- and Function-Dominant subgroups achieved functional recovery despite persisting symptoms. The Psychosocial-Dominant subgroup reported the greatest impairments in symptom and foot- and ankle-related quality of life at all time points. The Structure-Dominant subgroup experienced delayed improvement in symptoms and was the only subgroup to not achieve structural recovery. No subgroup met our criteria for complete recovery. CONCLUSION: The defining characteristics of Achilles tendinopathy subgroups were reproduced in a cohort with midportion Achilles tendinopathy. The Activity- and Function-Dominant subgroups had superior outcomes compared to the Psychosocial- and Structure-Dominant subgroups for symptomatic, functional, and structural recovery. J Orthop Sports Phys Ther 2023;53(4):217–234. Epub: 23 January 2023. doi:10.2519/jospt.2023.11330
Age-, Sex-, and Graft-Specific Reference Values From 783 Adolescent Patients at 5 to 7 Months After ACL Reconstruction: IKDC, Pedi-IKDC, KOOS, ACL-RSI, Single-Leg Hop, and Thigh Strength
Authors: Kuenze Christopher , Weaver Adam , Grindstaff Terry L. , Ulman Sophia , Norte Grant E. , Roman Dylan P. , Giampetruzzi Nicholas , Lisee Caroline M. , Birchmeier Thomas , Triplett Ashley , Farmer Brooke , Hopper Haleigh , Sherman David A. , Ness Brandon M. , Collins Katherine , Walaszek Michelle , Baez Shelby E. , Harkey Matthew S. , Tulchin-Francis Kirsten , Ellis Henry , Wilson Philip L. , Chang Edward S. , Wilcox C. Luke , Schorfhaar Andrew , Shingles Michael , Hart Joseph M. 
Published: January 2023

OBJECTIVE: To describe age-, sex-, and graft source-specific reference values for patient-reported, physical function, and strength outcome measures in adolescents at 5 to 7 months after anterior cruciate ligament reconstruction. DESIGN: Cross-sectional study. METHODS: Data were collected at 3 universities and 2 children's hospitals. The participants completed at least one of the International Knee Documentation Committee (IKDC) Subjective Evaluation Form, Pediatric IKDC (Pedi-IKDC), Knee Injury and Osteoarthritis Outcomes Score (KOOS), and Anterior Cruciate Ligament Return to Sport After Injury (ACL-RSI) Scale. Participants also completed single-leg hop tests and/or isokinetic quadriceps and hamstrings strength assessments (at 60°/s). Reference values were summarized using descriptive statistics and stratified for age, sex, and graft source. RESULTS: Reference values were reported for common patient-reported outcomes and measures of physical function and strength from 783 participants (56% females, age = 16. 4 ± 2.0 years) who were in early adolescence (12–14 years, N = 183, 52% females), middle adolescence (15–17 years, N = 456, 58% females), or late adolescence (18–20 years, N = 144, 55% females). Three hundred seventy-nine participants (48.4%) received a bone-patellar tendon-bone autograft, 292 participants (37.3%) received hamstring tendon autograft, and 112 participants (14.3%) received autograft or allograft from an alternative source. CONCLUSION: Reference values for common patient-reported outcomes and measures of physical function and strength differed depending on a patient's age, sex, and graft source. Using patient-specific reference values, in addition to previously described age-appropriate cutoff values, may help clinicians monitor and progress patients through rehabilitation and return to physical activity after anterior cruciate ligament reconstruction. J Orthop Sports Phys Ther 2023;53(4):194–201. Epub: 23 January 2023. doi:10.2519/jospt.2023.11389
NEUROLINGUISTIC PROGRAMMING IN SPORTS
Authors: Rohach Oksana , Wisecup Daniel 
Published: January 2023

In this article, we examine the literature presented on the use of neurolinguistic programming (NLP) in the world of sports. The techniques have been applied with success in a number of occasions at different skill levels to improve performance. NLP operates on the principle that human beings have the capacity to set and achieve their goals, and gives a framework in which these objectives can be attained. These principles have been observed in both a theoretical and practical way in relation to sports. In the first part of the article, we review the theoretical literature on the topic. From a theoretical standpoint, scholars have asserted that the perception of reality through the senses plays an important role, and this perception can be influenced by the language we use. Clear communication in teaching is vital for training athletes to reach their potential. In the second part, we look at applications of NLP in different spheres of sports and the way it is applied to real athletes with certain obstacles hindering their progress. We attempt to summarize this literature and present a potential path for future research. There have been criticisms of NLP, so it is important to consider them in an unbiased way, giving thought to what can be done in the future to give answer to them.