bluuebunny/crossref_metadata_2025_split huggingface dataset:
Op de Troon van Het Kruis
Authors: Davids A. 
Published: April 2023

On the throne of the cross
Dimitrios I, Ecumenical Patriarch of Constantinople (1972-1991)
His All Holiness Dimitrios I, Archbishop of Constantinople, New Rome, and Ecumenical Patriarch, died in Istanbul on the 2d of October 1991 after a heart attack. Dimitrios Papadopoulos, born in 1914 near Istanbul, studied at the Theological School at Chalki. After having spent a year in Northern Greece, he was ordained priest and looked after the parish in Feriköy at Istanbul. From 1945 to 1950 he organized the Greek Orthodox community in Teheran. Called back by patriarch Athenagoras I, he soon became auxiliary bishop of Istanbul. In 1972 he was appointed as metropolitan of Imbros and Tenedos, one of the four eparchies near Istanbul. After Athenagoras’ death he was unexpectedly and against his own will elected as ecumenical patriarch, while the Turkish authorities had refused the candidacy of other, more prominent members of the Holy Synod.
Dimitrios I continued and developped the work of his predecessor: with the preparation of the panorthodox council; with his „dialogue of truth” (instead of the former „dialogue of love”) with the Roman Catholic Church; with his collaboration with the World Council of Churches. Progress certainly has been made, but no final goal has been achieved. A panorthodox council is still not in view. The "dialogue of truth" is hampered by Roman Catholic proselytism in Eastern Europe. The World Council of Churches has departed too much from its „base”.
In the last years of his life Dimitrios could visit the Orthodox churches abroad, including the patriarchate of Moscow, as well as the Vatican, Canterbury and Geneva. In the U .S.A. he spoke to the United Nations. Thus he became an internationally well-known spiritual Orthodox leader. In the meantime he had to cope with extremist Turkish aggressivity at home. Dimitrios I was a humble successor of St. Andrew on, as he called it, „the throne of the cross”.
De Ikoon van de Opwekking van Lazarus
Authors: Jacobs A. 
Published: April 2023

L’icône de la résurrection de Lazare
Les catacombes nous off rent un grand nombre d’images représentant la résurrection de Lazare. Celui-ci y ressort comme symbole du défunt attendant sa résurrection par le Christ. La représentation est très simple: elle ne montre que les deux personnages principaux, le Christ et Lazare.
Sur les sarcophages on constate déjà un certain développement du thème. En plus du Christ et de Lazare il y ales femmes agenouillées aux pieds de Jésus et quelques témoins. Les icônes enfin montrent l’image la plus développée de la résurrection de Lazare. Elles suivent de près le texte de Saint-Jean et contiennent plusieurs détails mentionnés dans le récit évangélique. Ces icônes représentent le Christ comme vainqueur de la mort: celle de Lazare et celle de tous ceux qui croient en lui. En même temps elles sont – par voie de contraste – comme une annonce de la résurrection du Christ lui-même. Tandis que Lazare est ressuscité par le Christ, celui-ci quittera son tombeau de par sa propre force.
Effect of Chamomile on the Complications of Cancer: A Systematic Review
Authors: Maleki Maryam , Mardani Abbas , Manoochehri Mahdi , Ashghali Farahani Mansoureh , Vaismoradi Mojtaba , Glarcher Manela 
Published: April 2023

Background and objectives: Despite significant advances in the diagnosis and treatment of cancer, many people across the world still suffer from this chronic disease and its complications. Chamomile as an herbal medicine has gained an increasing attention for relieving cancer complications. This study aimed to integrate and synthesize current international evidence regarding the effect of chamomile on cancer complications. Methods: A systematic review was undertaken. Five online databases including Web of Science, PubMed [including MEDLINE], Cochrane Library, Scopus, and Embase were searched and articles published from inception to January 2023 were retrieved. All clinical trials and similar interventional studies on human subjects examining the effects of chamomile on cancer complications were included in the review and research synthesis. Relevant data were extracted from eligible studies after quality appraisals using proper methodological tools. The review results were presented narratively given that meta-analysis was impossible. Results: A total of 2240 studies were retrieved during the search process, but 18 articles were selected. The total sample size was 1099 patients with cancer of which 622 participants were female. Fifteen studies used an RCT design. Various forms of chamomile were used such as mouthwash, topical material, tea, capsule, syrup and aromatherapy massage. Chamomile effectively reduced oral mucositis, skin complications, depression, and vomiting and also improved appetite and quality of life among cancer patients. Conclusion: The use of chamomile as a non-pharmacologic and safe method can be helpful for mitigating cancer complications in patients with cancer. Therefore, it can be incorporated into routine care along with other therapeutic measures to reduce patients’ suffering related to cancer. Systematic review registration number (PROSPERO): CRD42022307887
Development and validation of a deep learning survival model for cervical adenocarcinoma patients
Authors: Li Ruowen , Qu Wenjie , Liu Qingqing , Tan Yilin , Zhang Wenjing , Hao Yiping , Jiang Nan , Mao Zhonghao , Ye Jinwen , Jiao Jun , Gao Qun , Cui Baoxia , Dong Taotao 
Published: April 2023

Abstract
Background
The aim was to develop a personalized survival prediction deep learning model for cervical adenocarcinoma patients and process personalized survival prediction.

Methods
A total of 2501 cervical adenocarcinoma patients from the surveillance, epidemiology and end results database and 220 patients from Qilu hospital were enrolled in this study. We created our deep learning (DL) model to manipulate the data and evaluated its performance against four other competitive models. We tried to demonstrate a new grouping system oriented by survival outcomes and process personalized survival prediction by using our DL model.

Results
The DL model reached 0.878 c-index and 0.09 Brier score in the test set, which was better than the other four models. In the external test set, our model achieved a 0.80 c-index and 0.13 Brier score. Thus, we developed prognosis-oriented risk grouping for patients according to risk scores computed by our DL model. Notable differences among groupings were observed. In addition, a personalized survival prediction system based on our risk-scoring grouping was developed.

Conclusions
We developed a deep neural network model for cervical adenocarcinoma patients. The performance of this model proved to be superior to other models. The results of external validation supported the possibility that the model can be used in clinical work. Finally, our survival grouping and personalized prediction system provided more accurate prognostic information for patients than traditional FIGO stages.
Application value of tumor necrosis factor inhibitors in in vitro fertilization-embryo transfer in infertile women with polycystic ovary syndrome
Authors: Liang Jun-xia , Zhang Yu , Xiao Chun-hui , Cao Shan , Tian Ying , Wang Na-na , Liu Chong 
Published: April 2023

Abstract
Background
Clinical value of tumor necrosis factor (TNF) inhibitors in in vitro fertilization-embryo transfer (IVF-ET) in infertile women with polycystic ovary syndrome (PCOS) was investigated in this study.

Methods
A retrospective analysis was performed on the clinical data of 100 PCOS patients who received IVF-ET for the first time at Hebei Institute of reproductive health science and technology from January 2010 to June 2020. The patients were divided into Inhibitor group and Control group according to whether they were treated with or without TNF inhibitors. Next, the two groups were subject to comparison in terms of the days of gonadotropin (Gn) use, total dosage of Gn, trigger time, hormone level and endometrial condition on the day of human chorionic gonadotropin (HCG) injection, the effects of two different regimens on controlled ovarian hyperstimulation (COH) and pregnancy outcomes.

Results
There were no significant differences in baseline characteristics between the two groups, including age, duration of infertility, body mass index (BMI), ovarian volume, antral follicle count, and basal hormone levels. Compared with the Control group, the days of Gn use and trigger time of patients in the Inhibitor group were significantly shortened, and the total Gn dosage was notably reduced. In terms of sex hormone levels on the HCG injection, the Inhibitor group displayed much lower serum estradiol levels while higher serum luteinizing hormone and progesterone (P) levels than the Control group. Notably, the high-quality embryo rate was also significantly increased with the use of TNF inhibitors. However, significant differences were not observed in endometrial thickness (on the day of HCG injection), proportion of endometrial A, B and C morphology (on the day of HCG injection), cycle cancellation rate, number of oocytes retrieved, fertilization rate, and cleavage rate between the two groups. Importantly, the clinical pregnancy rate in the Inhibitor group was significantly higher than that in the Control group, but there was no significant difference in the biochemical pregnancy rate, early abortion rate, multiple birth rate, ectopic pregnancy rate and number of live births between the two groups.

Conclusion
Collectively, after application of TNF-α inhibitor regimen, superior overall treatment effect can be observed in infertile PCOS patients receiving IVF-ET. Therefore, TNF inhibitors have certain application value in IVF-ET in infertile women with PCOS.
The post-discharge coping difficulty of puerperal women in a middle and low-income tourist city during the COVID-19 pandemic
Authors: Liu Yan , Peng Lan-lan , Zhang Yi-yuan , Tang Mei-yin , Tang Mei-qiong , Xu Yun-yun , Ma Zong-ying , Tang Yi , Gao Lingling 
Published: April 2023

Abstract
Background
Since the coronavirus disease 2019 (COVID-19) pandemic outbreak, the incidence of mental health problems in perinatal women has been high, and particularly prominent in China which was the first country affected by COVID-19. This paper aims to investigate the current situation and the related factors of maternal coping difficulties after discharge during COVID-19.

Methods
General information questionnaires (the Perinatal Maternal Health Literacy Scale, Postpartum Social Support Scale and Post-Discharge Coping Difficulty Scale-New Mother Form) were used to investigate 226 puerperal women in the third week of puerperium. The influencing factors were analyzed by single factor analysis, correlation and multiple linear regression.

Results
The total score of coping difficulties after discharge was 48.92 ± 12.05. At the third week after delivery, the scores of health literacy and social support were 21.34 ± 5.18 and 47.96 ± 12.71. There were negative correlations among health literacy, social support and coping difficulties after discharge (r = -0.34, r = -0.38, P < 0.001). Primipara, family income, health literacy and social support were the main factors influencing maternal coping difficulties after discharge.

Conclusion
During the COVID-19 pandemic, puerperal women in a low- and middle-income city had moderate coping difficulties after discharge and were affected by many factors. To meet the different needs of parturients and improve their psychological coping ability, medical staff should perform adequate assessment of social resources relevant to parturients and their families when they are discharged, so they can smoothly adapt to the role of mothers.
Effects of preoperative albumin-to-globulin ratio on overall survival and quality of life in esophageal cell squamous carcinoma patients: a prospective cohort study
Authors: Zhang Juwei , Lin Zheng , Zhou Jinsong , Huang Yue , Chen Siting , Deng Yuan , Qiu Minglian , Chen Yuanmei , Hu Zhijian 
Published: April 2023

Abstract
Objective
This study aimed to investigate the effect of preoperative albumin-to-globulin ratio (AGR) on overall survival (OS) and health-related quality of life in patients with esophageal cell squamous carcinoma (ESCC).

Methods
Serum albumin and globulin were measured within one week before surgery. Multiple follow-ups were conducted among patients with ESCC in the study in order to assess their life quality. The method used in the study was a telephone interview. Quality of life was measured using the EORTC Quality of Life Questionnaire-Core Questionnaire (EORTC QLQ-C30, version 3.0) and Esophageal Cancer Module (EORTC QLQ- OES18).

Results
A total of 571 ESCC patients were included in the study. The results illustrated that 5-year OS of high AGR group (74.3%) was better than the low one (62.3%) (P = 0.0068). Univariate and multivariate Cox regression analysis found that preoperative AGR (HR = 0.642, 95%CI: 0.444–0.927) are prognostic factor for patients with ESCC after surgery. In terms of quality of life, found that low AGR associated with increased postoperative time to deterioration (TTD) events in ESCC patients, and compared to low AGR, high AGR could delay the deterioration of emotional functioning(P = 0.001), dysphagia(P = 0.033), trouble with taste(P = 0.043) and speech problems(P = 0.043). After using the multivariate Cox regression analysis showed that high AGR could improve patients’ emotional function (HR = 0.657, 95% CI: 0.507–0.852) and trouble with taste (HR = 0.706, 95% CI: 0.514–0.971).

Conclusions
Preoperative AGR in patients with ESCC after esophagectomy was positively correlated with overall survival rate and quality of life after operation.
Association between diet quality scores and risk of overweight and obesity in children and adolescents
Authors: Zheng Xiaoyun , Wang Hong , Wu Huiwen 
Published: April 2023

Abstract
Background
This study examined the associations of diet quality assessed by Healthy Eating Index 2015 (HEI-2015), Alternative Healthy Eating Index 2010 (AHEI-2010), Mediterranean Diet (MedDiet) and overweight/obesity in children and adolescents.

Methods
This cross-sectional study used data of participants aged 2–19 years from National Health and Nutrition Examination Survey (NHANES) 2005–2018. The weighted logistic regression model was adopted to explore the association between diet quality scores and overweight, obesity in children and adolescents. Subgroup analysis was also performed based on sex.

Results
A total of 9,724 participants were included in children group (2–11 years old), and 5,934 were adolescent group (12–19 years old). All participants were divided into based on the BMI-for-age: underweight and normal, overweight and obesity groups. After adjusting for age, race, poverty-income ratio, maternal smoking during pregnancy and total energy, HEI-2015 and MedDiet scores were related to the risk of overweight in children, and only MedDiet scores remained associated with a decreased risk of obesity in children. MedDiet scores were associated with a decreased risk of overweight, obesity in adolescents, respectively, after adjusting age, sex, race, poverty-income ratio, cotinine, total energy and physical activity. The similar results in male participants were also found.

Conclusion
Higher MedDiet scores were associated with lower the risk of overweight and obesity, respectively, particularly for male children and adolescents. The higher HEI-2015 scores were also related to the risk of overweight in children.
Insights into SGLT2 inhibitor treatment of diabetic cardiomyopathy: focus on the mechanisms
Authors: Huang Keming , Luo Xianling , Liao Bin , Li Guang , Feng Jian 
Published: April 2023

AbstractAmong the complications of diabetes, cardiovascular events and cardiac insufficiency are considered two of the most important causes of death. Experimental and clinical evidence supports the effectiveness of SGLT2i for improving cardiac dysfunction. SGLT2i treatment benefits metabolism, microcirculation, mitochondrial function, fibrosis, oxidative stress, endoplasmic reticulum stress, programmed cell death, autophagy, and the intestinal flora, which are involved in diabetic cardiomyopathy. This review summarizes the current knowledge of the mechanisms of SGLT2i for the treatment of diabetic cardiomyopathy.Graphical Abstract
HIV and HCV among drug users and people living in prisons in Germany 2022: WHO elimination targets as reflected in practice
Authors: Stöver H. , Dichtl A. , Schäffer D. , Grabski M. 
Published: April 2023

AbstractPeople who inject drugs (PWID) and prisoners are considered key populations at risk for human immunodeficiency virus (HIV) and/or Hepatitis C Virus (HCV). In 2016, the Joint United Nations Program on HIV/AIDS (UNAIDS) was implemented to eliminate HIV and AIDS by 2030 and the World Health Organization (WHO) presented the first strategy to eliminate viral hepatitis by 2030 as well. Following the objectives of the WHO and the United Nations, the German Federal Ministry of Health (BMG) presented the first integrated overall strategy for HIV and HCV in 2017. This article discusses the situation of PWID and prisoners in Germany with regard to HIV and HCV five years after the adoption of this strategy, on the basis of available data and against the background of the most recent practice in the field. In order to meet the elimination goals by 2030, Germany will have to improve the situation of PWID and prisoners substantially, mainly through the implementation of evidence-based harm reduction measures as well as the promotion of diagnosis and treatment in prisons and in freedom.
Cancer and COVID-19: unravelling the immunological interplay with a review of promising therapies against severe SARS-CoV-2 for cancer patients
Authors: Leyfman Yan , Emmanuel Nancy , Menon Gayathri P. , Joshi Muskan , Wilkerson William B. , Cappelli Jared , Erick Timothy K. , Park Chandler H. , Sharma Pushpa 
Published: April 2023

AbstractCancer patients, due to their immunocompromised status, are at an increased risk for severe SARS-CoV-2 infection. Since severe SARS-CoV-2 infection causes multiple organ damage through IL-6-mediated inflammation while stimulating hypoxia, and malignancy promotes hypoxia-induced cellular metabolic alterations leading to cell death, we propose a mechanistic interplay between both conditions that results in an upregulation of IL-6 secretion resulting in enhanced cytokine production and systemic injury. Hypoxia mediated by both conditions results in cell necrosis, dysregulation of oxidative phosphorylation, and mitochondrial dysfunction. This produces free radicals and cytokines that result in systemic inflammatory injury. Hypoxia also catalyzes the breakdown of COX-1 and 2 resulting in bronchoconstriction and pulmonary edema, which further exacerbates tissue hypoxia. Given this disease model, therapeutic options are currently being studied against severe SARS-COV-2. In this study, we review several promising therapies against severe disease supported by clinical trial evidence—including Allocetra, monoclonal antibodies (Tixagevimab–Cilgavimab), peginterferon lambda, Baricitinib, Remdesivir, Sarilumab, Tocilizumab, Anakinra, Bevacizumab, exosomes, and mesenchymal stem cells. Due to the virus’s rapid adaptive evolution and diverse symptomatic manifestation, the use of combination therapies offers a promising approach to decrease systemic injury. By investing in such targeted interventions, cases of severe SARS-CoV-2 should decrease along with its associated long-term sequelae and thereby allow cancer patients to resume their treatments.
Proteomic analysis of extracellular vesicles from tick hemolymph and uptake of extracellular vesicles by salivary glands and ovary cells
Authors: Xu Zhengmao , Wang Yanan , Sun Meng , Zhou Yongzhi , Cao Jie , Zhang Houshuang , Xuan Xuenan , Zhou Jinlin 
Published: April 2023

Abstract
Background
Extracellular vesicles (EVs) are a heterogeneous group of cell-derived membranous structures that are important mediators of intercellular communication. Arthropods transport nutrients, signaling molecules, waste and immune factors to all areas of the body via the hemolymph. Little is known about tick hemolymph EVs.

Methods
Hemolymph was collected from partially fed Rhipicephalus haemaphysaloides and Hyalomma asiaticum ticks by making an incision with a sterile scalpel in the middle (between the femur and metatarsus) of the first pair of legs, which is known as leg amputation. EVs were isolated from hemolymph by differential centrifugation and characterized by transmission electron microscopy (TEM) and nanoparticle tracking analysis (NTA). Proteins extracted from the hemolymph EVs were analyzed by 4D label-free proteomics. The EVs were also examined by western blot and immuno-electron microscopy analysis. Intracellular incorporation of PHK26-labeled EVs was tested by adding labeled EVs to tick salivary glands and ovaries, followed by fluorescence microscopy.

Results
In this study, 149 and 273 proteins were identified by 4D label-free proteomics in R. haemaphysaloides and H. asiaticum hemolymph EVs, respectively. TEM and NTA revealed that the sizes of the hemolymph EVs from R. haemaphysaloides and H. asiaticum were 133 and 138 nm, respectively. Kyoto Encyclopedia of Genes and Genomes and Gene Ontology enrichment analyses of identified proteins revealed pathways related to binding, catalytic and transporter activity, translation, transport and catabolism, signal transduction and cellular community. The key EV marker proteins RhCD9, RhTSG101, Rh14-3-3 and RhGAPDH were identified using proteomics and western blot. The presence of RhFerritin-2 in tick hemolymph EVs was confirmed by western blot and immuno-electron microscopy. We demonstrated that PKH26-labeled hemolymph EVs are internalized by tick salivary glands and ovary cells in vitro.

Conclusions
The results suggest that tick EVs are secreted into, and circulated by, the hemolymph. EVs may play roles in the regulation of tick development, metabolism and reproduction.

Graphical Abstract