bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intraovarian platelet-rich plasma injection: a potential path to genetic parenthood for women with low ovarian reserve
Authors: Kaul Nalini 
Published: January 2025

Background: The incidence of women with low ovarian reserve (LOR) presenting for ART is increasing. Infertility management is challenging since oocyte numbers are related to IVF success. The use of intraovarian platelet rich plasma (IOPRP) is emerging as a promising technique for ovarian rejuvenation. This study evaluates role of IOPRP in improving ovarian reserve markers, ovarian response and reproductive outcomes in women with LOR keen to achieve genetic parenthood.
Methods: This prospective observational cohort study was done on 85 women of Indian ethnicity 25-50 years, Poseidon group 3 and 4, infertility >3 years wih at least 1 previous IVF failure. One ml of PRP prepared by double centrifugation technique was injected into each ovary transvaginally. AMH, AFC, FSH, ovarian response measured pre and post IOPRP.
Results: At 8 weeks post PRP a statistically significant increase in AMH (0.57±0.33 ng/ml vs 0.96±0.49 ng/ml p<0.001), AFC (4.11±1.81 vs 7.81±3.35 p<0.001), number of oocytes retrieved (3.29±2.22 vs 5.52±3.66 p<0.001) and number of usable embryos (1.11±1.21 vs 2.33±2.12, p<0.001) was seen. Of women who underwent IVF 57.1% achieved clinical pregnancy. Overall Live birth rate was 38.09%, 8 women conceived without IVF with a live birth rate of 40%. Poseidon group 3 showed a greater improvement.
Conclusions: The study suggests that IOPRP treatment increases ovarian reserve markers and response and may be a viable alternative to donor oocytes in women with LOR wanting genetic parenthood.
The effect of the method of production a new fertilizer containing Streptomyces coelicolor grown on whey on its effectiveness
Authors: Magradze E. I. 
Published: January 2025

Relevance. In recent years, we have seen an increase in the number of new bacterial fertilizers. New fertilizers must be effective, so it is important to select their qualitative and quantitative composition. It is equally important to study the effect of these bacteria on their number, dissemination and long-term residence in the soil, as well as their effects on plants.Aim of the Study. This work studies the effect of the method of obtaining a fertilizer containing Streptomyces coelicolor grown on the whey on the amount and duration of these bacteria in the soil and on the growth characteristics of white mustard (Sinapis alba L.) sown into the soil after a long time after watering with fertilizer.Methods. The whey was diluted and autoclaved, Streptomyces coelicolor were grown on this substrate. An inoculum for this biofertilizer was obtained in two ways. The first way: Streptomyces coelicolor were grown once on a Waksman`s media. The second way: the inoculum was sequentially grown on the whey, gradually increasing the volume. Bacteria in fertilizer were cultivated without mixing or by mixing in the temperature-controlled shaker. We studied the effect of biofertilizer on soil in containers in the laboratory. The amount of Streptomyces coelicolor in the soil was determined 0.5, 1.5, 2 and 4 months after watering by fertilizer. Seeds of white mustard were sown two months after watering with fertilizer. We studied the effect of fertilizer on growth characteristics of white mustard.Results. The fertilizer obtained by sequentially cultivating the inoculum and growing streptomyces without mixing contained ten times more streptomyces than fertilizers obtained by another method. This biofertilizer also effectively increased the number of streptomyces in the soil. Streptomyces from fertilizer have been preserved in the soil for a long time. The effect of biofertilizers obtaining without mixing on growth characteristics of white mustard was the most effectively.Conclusion. The fertilizer obtained by sequentially cultivating the inoculum and growing streptomyces without mixing contributes to a more increase of streptomyces number in the soil and is more effective in growing white mustard then fertilizers obtained by other methods. Our biofertilizer is effective in growing crops sown in the soil for a long time after watering with fertilizer. The fertilizer can be used in indoor crop production and greenhouse farms.
Mineral nutrition system for chicory root culture
Authors: Vyutnova O. M. , Smirnova I. V. , Novikova I. A. , Maksimova K. S. 
Published: January 2025

Relevance. Chicory root (Cichorium intybus) is a very valuable technical, vegetable and medicinal crop. The development and improvement of a scientifically based fertilizer system is one of the most important issues in agricultural production, since it determines not only the level of crop yield, but also the direction of changing, increasing and preserving soil fertility in general.Material and Methods. The aim of the research was to identify the most effective doses of mineral fertilizers and methods of their application (basic and top dressing) to ensure maximum yields of root chicory root crops. The research was carried out in 2021-2022 in the field of the Rostov Vegetable experimental station on chicory – Branсh of the Federal State Budgetary Scientific Institution Federal Scientific Vegetable Center. Chicory seeds of the Petrovsky root variety were used for sowing. Mineral fertilizers were applied in the form of azophosphate and potassium sulfate.Results. On sod-podzolic soils, the use of mineral fertilizers had a positive effect on the yield of chicory root crops. The more developed the leaf rosette of plants, the higher the yield of root chicory.Conclusion. In the soil and climatic conditions of the Non-Chernozem zone of the Russian Federation, the greatest effect from the use of mineral fertilizers on root chicory is observed with a mineral nutrition system that includes the main application at a dose of N60P60K60 and top dressing at a dose of N60P60K60.
Management and Ecological Services of Multipurpose Agroforestry Tree Species in Ethiopia. Review
Authors: Biru K. H. , Cheru U. 
Published: January 2025

Relevance. Ethiopians have a long history of planting trees, and they have embraced the idea of keeping natural trees with many uses as a distinctive feature of their agricultural landscapes. Farmers use agroforestry practices to maintain a number of species of multipurpose trees. The selection of tree species, their intended benefits, and ecological services are inconsistent due to variability in agroecological conditions. The main problems with Ethiopia's multifunctional agroforestry tree species were also related to management approaches.Therefore, the purpose of this article is to examine the multipurpose agroforestry tree species in Ethiopia, their management methods, and their ecological benefits. In southern Ethiopia, Cordia africana, Millettia ferruginea, Erythrina brucei, and Olea capensis are the main multifunctional tree species used. The northern part of Ethiopia hosts Croton macrostachus, Vernonia amygdalina, Faidherbia albida, Acacia nilotica, Acacia seyal, and Grewia bicolor. The central highlands of Ethiopia are also home to Albizia gummifera, Cordia africana, Croton macrostachus, Ficus vasta, and Vernonia amygdalina. Farmers use coppicing, pollarding, and pruning tree management techniques to balance their survival with integrated crops because trees regenerate naturally. Multipurpose trees offer a range of agro-ecological services, such as improving soil fertility, mitigating erosion, mitigating the impacts of climate change, and maintaining biological diversity.
Aqueous extract of Astilbe chinensis leaves as a potential medicine to slow activity of digestive enzymes
Authors: Sokolova E. V. , Krol T. N. , Baleev D. N. 
Published: January 2025

Relevance. Astilbe chinensis has clinical efficacy against many diseases, making this plant a potential natural source for treating diabetes and obesity with a mild, non-aggressive effect. Overall, the study of the biological properties of A. chinensis leaves is currently in its infancy.Aim. In this study, the anti-amylase and anti-lipase potential of aqueous extract of Astilbe chinensis leaves was investigated as an important source of natural complex substances with therapeutic potential. Methods. The total content of phenolic compounds was determined by the Folin-Ciocalteu method and flavonoids by the colorimetric method according to the complexation reaction with aluminum chloride. The effects of aqueous/tea extracts of A. chinensis leaves on pancreatic amylase and lipase were studied via in vitro models in comparison with acarbose and orlistat, respectively. For these tests, the artificial substrates 1,2-O-dilauryl-rac-glycero-3-glutaric acid ester (6-methylresorufin) and 2-chloro-4-nitrophenol oligosaccharide were used.Results. The study of the effect of aqueous extract of A. chinensis leaves on pancreatic amylase and lipase showed a comparable inhibitory effect of 18% on both enzymes.
Relationship between Forage Particle Size and Rate of in vitro Digestion Parameters of Alfalfa-based Lamb in Complete Pelleted Diets
Authors: Alharthi Abdulrahman S. , Alshamiry Faisal A. , Alghonaim Ahmed A. , Al-Baadani Hani H. , Alhidary Ibrahim A. 
Published: January 2025

Background: Intensive feeding systems for lamb production are based on high concentrations of feed, depending on the type of forage, which can cause digestive disturbances; however, forage particle length (FPL) and size (FPS) can affect the fermentation process and the productive performance of lambs. Intensive feeding systems for lamb production are based on high concentrations of feed, depending on the type of forage, which can cause digestive disturbances; however, forage particle length (FPL) and size (FPS) can affect the fermentation process and the productive performance of lambs. Understanding how the lambs meet these challenges requires a conceptual integration of forage structure, mechanical particle size of forage and microbial fermentation. This synthesis will hopefully contribute to the development of a biomimetic co-treatment process for translating the unique characteristics of digestion into an effective component of biorefineries for the industrial conversion of cellulosic in forage biomass to useful products. Therefore, this study aimed to evaluate the relationship among FPL, degradability of feed in vitro and digestibility of organic materials. Methods: As a laboratory simulation of rumen functions, four alfalfa FPS lengths were studied within the components of integrated feed pellets 0.1 mm, common in the Saudi animal feed market, 5, 10 and 15 mm using the same feed composition, but with different lengths. Result: Cumulative gas production in PSL8 and PSL12 lambs was higher compared with the other two groups, indicating that lengths greater than 15 mm and less than 5 mm affected gas production rates. The effect of FPL on rumen parameters had no effect on the pH of the rumen fluid. There were no significant differences in all values of the main volatile fatty acids acetate, propionate and butyrate and digestibility increased when the FPL ranged from 5 to 10 mm as in the PSL5 and PSL10 groups. Hydrogen levels were significantly higher in the PSL1 and PSL10 groups than in the PSL5 and PSL15 groups. Based on forage size, groups PSL5 to PSL10 showed the possibility of using this type of feed for growing lambs and small ruminants.
Influence of rheometer configurations on the rheological analysis of different types of concrete
Authors: Satapathy Ashirbad , Bishnoi Shashank 
Published: January 2025

Abstract

Concrete rheometry has been a topic of research for the last few decades in order to ensure objective and comprehensive evaluation of fresh concrete behaviour. However, a number of artefacts and the incompatibility with certain rheometer geometries reduce the accuracy of the rheological analysis of concrete. It is, therefore, essential to match the right kind of rheometer configuration for a given concrete type. This paper investigates the compatibility of three different types of concrete mixes – self-compacting concrete (SCC), pumpable concrete (PC), and mortar mix (M) – with three rheometer configurations. Out of the three rheometer geometries, two are coaxial cylinder based, viz. vane impeller with smooth-walled container (V), slotted-vane impeller with ribbed-walled container (SV), and the other one is an attritor impeller with a smooth-walled container (AP) rotating in a planetary motion. Flow curve tests are carried out at different time intervals and compared with the corresponding slump/slump spread value. Stress growth tests (SGT) are performed to study the evolution of the static yield stress with time. A unique approach – SB’s L-Box analysis – has been developed to assess the noise-to-signal (N/S) ratio and, thereby, estimate the quality of data obtained from the SGTs. It was observed that the SGT data for the SCC and PC mixes are not reliable due to large noise and scatter, probably caused by the inclusion of coarse aggregates. The slotted-vane impeller was found to be the best choice among all the geometries. Furthermore, it was emphasised that an SB’s L-Box analysis of the SGT data could give important information on the compatibility of a rheometer configuration with a given concrete type. An N/S ratio of less than 0.20 was recommended for obtaining reliable data.
Environmental Impact Measurement and Chromatic Performance Evaluation of Denim Washing: A Comparison to Conventional and Sustainable Approaches for Cleaner Production
Authors: Rahaman Md.Tareque , Hasan Md. Kamrul , Khan Md.Shakib Hossain 
Published: January 2025

Abstract

Over the past few decades, several developments and innovations have made denim a "classic" in today's fashion cycle. Modern consumers today are concerned with clothing comfort, environmental sustainability, and aesthetic appeal. Sustainability in denim washing is a pressing concern in the fashion industry, affecting consumers' purchasing decisions. Sustainable alternatives for denim enthusiasts now include eco-friendly alternative garments dry and wet processes through nontoxic chemicals, process optimization, and washing recipe optimization. Previous research focused solely on the physical properties of denim samples following the use of hazardous conventional denim washing techniques; yet those did not adequately represent empirical assessments of the environmental impact measurement, chromatic values, and visual uniformity of vintage effects on vat-dyed denim. This research compares the three conventional washing techniques such as dark, medium, and light washes with their sustainable counterparts, analyzing their environmental impacts and chromatic evaluation. Sustainable washing techniques tend to be more efficient, saving at least 15.5-21.5 minutes per wash. While medium and dark washing save 14.44 L/kg and 19.4 L/kg of water, respectively, sustainable light washing saves 3.9 L/kg. Sustainable washes are more economical and those techniques also consume less energy and have lower chemical and energy impact scores than conventional washes. The Environmental Impact Measurement (EIM) scoring system implies 0–33 for low impact, 34–66 for medium impact, and >66 for high impact. EIM score of conventional washing methods (42 for light, 51 for medium, and 57 for dark wash) is greater than that of sustainable washing methods (8 for light, 13 for medium, and 17 for dark wash). Evaluations indicate a decline in color strength (K/S), chromaticity (C*), and hue angle (h) for light-washed denim of conventional and sustainable types. Conversely, the light-washed samples show higher color difference (ΔE), and CIE L*a*b* values in comparison to medium and dark-washed denim samples of conventional and sustainable types. This research provides a comprehensive assessment using metrics like EIM score, color differences, color strength, chromaticity, and hue angle.
Optimizing EMS Response Times with Machine Learning: A Multivariate Analysis for Enhanced Resource Allocation
Authors: Hill Peter , Lederman Jakob , Jonsson Daniel , Bolin Peter , Vicente Veronica 
Published: January 2025

Abstract

Background
This study examines the multifaceted determinants of Emergency Medical Services (EMS) response times through a machine learning approach. Using data from over one million EMS missions spanning 2017 to 2022, this research aims to understand and predict factors influencing response times, highlighting the role of machine learning in optimizing emergency services.
Methods
Advanced machine learning techniques, including Gradient Boosting models, were employed to analyze response times across various emergency scenarios. The data set was carefully curated to consider numerous factors such as urgency levels, call handling times, travel times, and geographical and temporal variables.
Results
The analysis confirms significant variability in response times influenced by factors such as the urgency of calls, weather conditions. Adverse weather and extreme temperatures were found to exacerbate response times significantly. Central urban areas showed faster response times compared to remote regions. The machine learning models effectively identified and quantified these impacts, offering a nuanced understanding that can inform more targeted EMS deployment strategies.
Conclusions
The findings advocate for the integration of real-time data on traffic, weather, and incident specifics into EMS resource allocation strategies to optimize response times dynamically. This approach underscores the importance of leveraging predictive analytics in emergency response planning, enhancing service delivery and patient outcomes. The study not only contributes to academic knowledge but also provides practical insights for emergency service administrators aiming to improve operational efficiency and response effectiveness.
Follow the Money: Are Severe Weather Events Value Relevant?
Authors: Liu Lisa , Agrawal Sonakshi , Rajgopal Shivaram 
Published: January 2025

Abstract

An important contemporary policy debate relates to whether climate risk significantly impacts a firm’s financial performance. Our examination of this debate leads to three key findings. First, a severe weather event knocks off 1.3% of an affected public firm’s market capitalization. Second, specific industries and certain time periods drive statistically significant stock price reactions. Moreover, firms that disclose climate risks tend to experience slightly smaller stock price reactions. Third, private companies are particularly susceptible to the negative financial impact of natural disasters. However, private firms exhibit greater resilience when they receive financial assistance from government programs and when they are diversified across geographies. We caution policymakers on disclosures aimed at regulating public firms’ disclosure of climate risks while the disproportionate financial impact of severe weather events potentially affects private firms.
JEL: D03, G14, G18, G38, K22, K32, M41, M48.
Climate feedback of forest fires amplified by atmospheric chemistry
Authors: Chen Wei , Zhang Yuzhong , Zou Yufei , Zhang Zhen 
Published: January 2025

Abstract

Intensified forest wildfires, driven by climate change, release reactive gases that lead to reduced atmospheric oxidation capacity, hence increasing methane levels and amplifying warming. Our integrated analysis of fire and chemistry models projects that additional warming by this mechanism rivals that of wetland methane feedback and fire CO2 feedback by the 2050s under the intermediate climate pathway. Our finding highlights a critical role of atmospheric chemistry in regulating fire-climate feedback.
Longitudinal characterization of clinical, developmental, and behavioral phenotypes in 101 children and adults with FOXG1 syndrome
Authors: Brimble Elise , Ventola Pam , Blomenberg Elizabeth , Frahlich Kelsey , Kuhathaas Kopika , Hart Christopher E , Bahi-Buisson Nadia , Olson Heather E , Marsh Eric D , Ayalon Gai 
Published: January 2025

Abstract

Background
FOXG1 syndrome is a severe genetic neurodevelopmental disorder characterized by developmental and intellectual disabilities (DD/ID), postnatal microcephaly, epilepsy, and movement disorder. With the advent of molecular therapies, establishing the natural history of FOXG1 syndrome is critical to enable clinical trial readiness. However, traditional study designs are challenging to implement for rare disorders without significant burden to participants.
Methods
The study population included 101 children and adults with (likely) pathogenic variants in or involving FOXG1 (ages 0.4 - 34.8 years). Participant medical records underwent systematic annotation and harmonization of recorded clinical phenotypes, interventions, and outcomes through use of a patient-centric real-world data (RWD) platform. Retrospective medical record data were paired with prospective administration of validated measures of development and behavior, including the Vineland-3, the Aberrant Behavior Checklist, and the Children’s Sleep Habits Questionnaire. Descriptive and inferential statistics were employed to characterize longitudinal phenotypes and to explore genotype-phenotype correlations.
Results
Through systematic evaluation of 101 people with FOXG1 syndrome, we generated a robust dataset encompassing >40,000 annotated clinical terminology concepts that represent >770 cumulative patient data years. Core clinical phenotypes include DD/ID, gastrointestinal disorders, strabismus, epilepsy, movement disorders, and sleep problems. The FOXG1 syndrome behavioral phenotype is characterized by irritability, including aggressive behaviors, stereotypies, social withdrawal, and lethargy; in those with missense variants, features of autism spectrum disorders are also reported. Data derived from both medical records and validated measures confirm and expand upon previously described genotype-phenotype correlations, whereby truncating variants are associated with greater limitations across motor and communication domains, as well as increased frequency of core FOXG1 syndrome phenotypes. Further, individuals with truncating variants had higher scores on a composite measure of FOXG1 syndrome severity, which persists when modeled longitudinally. Employing the same composite measure, we demonstrate that FOXG1 syndrome is a static encephalopathy without evidence of neurodegeneration.
Conclusions
By combining retrospective RWD with prospective survey administration in a large sample population, we establish the natural history of FOXG1 syndrome and highlight candidate clinical endpoints for use in clinical trials, including quantitative evaluations of communication and movement disorders.
Interface-mediated dc electro-optic instability in lithium niobate nanophotonics
Authors: Yeh Matthew , Barton David , Smith Gavin , Day Aaron , Raun Alexander , Renaud Dylan , Assumpcao Daniel , Hu Evelyn , Loncar Marko 
Published: January 2025

Abstract

In certain materials, the linear electro-optic (Pockels) effect allows direct control of the refractive index with an applied electric field. In practice, material inhomogeneities and defects cause the field inside the material to drift over macroscopic time scales. Such phenomena degrade the reliability and stability of integrated electro-optic devices. Here, we combine systematic measurements of dc electro-optic response, electronic transport, and elemental composition to examine the microscopic origins of dc instability in nanofabricated thin-film lithium niobate (TFLN) devices. We identify two key sources of instability: the metal-LN contact interface where Schottky barriers impede charge injection, and the oxide-LN cladding interface where lithium diffusion occurs. Our work provides an electronic understanding of a long-standing photonics issue, advancing a potential pathway toward high-performance integrated electro-optic devices through materials-motivated design.