bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of Volatile Constituent by Hydrodistillation and Solid‐Phase Microextraction Techniques and Antimicrobial and Scolicidal Activities of Essential Oil and Soxhlet Extracts of Ulva rigida grown in Turkey
Authors: Yücel Tayyibe Beyza , Korkmaz Büşra , Cebeci Tuğba , Karaman Ülkü , Arici Yeliz Kasko , Fandakli Seda , Gül Tuba 
Published: August 2023

AbstractIn the present study, the volatile composition of Ulva rigida (U. rigida) was elucidated by two different methods. As a result of the identification process of volatile components using the GC/MS‐FID instrument, 31 compounds were identified by hydrodistillation (HD) method, and 15 compounds were identified by solid‐phase microextraction (SPME) method, elucidating the structure of 99.86 % and 92.65 %, respectively. The most abundant compounds in the essential oil of U. rigida were n‐hexadecanoic acid and pentadecanal, while the most abundant compound according to the SPME analysis was heptadecyne, a hydrocarbon compound. In the next step, hexane, dichloromethane, chloroform and methanol solvent extracts of U. rigida were prepared and the antimicrobial activities of the extracts and the essential oil obtained by hydro‐distillation as well as the scolicidal activities of the solvent extracts were determined. The results of the antimicrobial activity test of the essential oil showed a high level of activity against Bacillus cereus ATCC 10876 and MRSA. The highest activity was found on the microorganism of Pseudomonas aeruginosa ATCC 9027 in chloroform and methanol extracts of U. rigida. Furthermore, viability detection was performed and the scolicidal effects of the extracts on protoscoleces were assessed. The values of lethal concentration doses (LD50, LD75 and LD90) were calculated using probit analysis.
New Guaiane‐Type Sesquiterpene and Norsesquiterpene from Alisma plantago‐aquatica and Their Xanthine Oxidase Inhibitory Activity
Authors: Thanh Nguyen Thi Viet , Tung Dang Thanh , Hoang Vu Dinh , Yen Pham Hai , Tai Bui Huu 
Published: August 2023

AbstractA new sesquiterpene (1) and a new norsesquiterpene (2) belonging guaiane‐type skeleton together with six known compounds (3–8) were isolated from the rhizomes of Alisma plantago‐aquatica. Their structures were determined by HR‐ESI‐MS, 1D and 2D NMR spectroscopic methods. Absolute configurations of new compounds were established by experimental and TD‐DFT computational ECD spectra. Compounds 1–8 exhibited xanthine oxidase inhibitory activity with their IC50 values in range of 9.4–66.7 μM. The sesquiterpenoids 1–5 displayed the inhibitory activity and hence they could be potential xanthine oxidase inhibitors from A. plantago‐aquatica.
ROS‐Sp1 axis is involved in thermochemotherapy‐enhanced sensitivity of pancreatic cancer cells to gemcitabine
Authors: Xi Pan , Ma Xiaojuan , Hu Fuquan , Li Liang , Liu Huijuan , Zhou Jing , Wu Wenan 
Published: August 2023

AbstractGemcitabine (GEM)‐based chemotherapy represents the first choice for locally unresectable advanced pancreatic cancer, while the benefit is limited due to acquired chemoresistance or drug delivery insufficiency. Hyperthermia treatment potentially improves the clinical efficacy of GEM. However, the underlying mechanism is incompletely revealed. Our study aims to investigate the effect and involved mechanism of thermochemotherapy on cell survival. Pancreatic cancer cells PANC‐1 and ASPC‐1 were either treated with GEM or thermochemotherapy, then cell viability, apoptosis, migration, invasion, reactive oxygen species (ROS) production, and Sp1 expression were evaluated. The results showed that GEM dose and time‐dependently affected cell viability, and 30 μM GEM achieved favorable effect in suppressing cancer cell growth. Meanwhile, hyperthermia preconditioning (43°C for 60 min) 24 h before GEM treatment yielded superior effect than other treatment sequence. GEM caused significant cell apoptosis and proapoptotic genes of both cancer cells, and thermochemotherapy further promoted apoptosis and genes transcription, accompanied by excessive ROS production. Thermochemotherapy was superior to GEM in suppressing cell migration and invasion of pancreatic cancer cells. Meanwhile, GEM significantly reduced Sp1 mRNA and protein and its downstream gene Cox‐2, and thermochemotherapy further suppressed their expressions. ROS elimination with N‐acetyl‐l‐cysteine notably neutralizes the suppressive effect of GEM and thermochemotherapy on cell growth and expressions of Sp1 and Cox‐2. In conclusion, thermochemotherapy inhibited pancreatic cell viability, migration and invasion, and promoted cell apoptosis by inducing excessive ROS production, which subsequently suppressed Sp1 expression and the downstream Cox‐2.
Influence of bran layer on rice milling quality
Authors: Oppong Siaw Michelle , McClung Anna M. , Mauromoustakos Andy , Wang Ya‐Jane 
Published: August 2023

AbstractBackground and ObjectivesRice milling involves applying forces to remove bran from brown rice to produce milled rice. The physical and chemical properties of a rice kernel may affect both the amount of bran removed during milling and the amount of head rice yield (HRY) produced, which is a determinant of crop value. This study investigated bran thickness and bran chemical composition as factors that influence bran removal and HRY as a result of milling.FindingsThe results showed that brown rice kernels with initial higher surface lipid contents (SLCs) required longer milling times to achieve 0.4% SLC, but the longer milling times did not translate into lower HRYs or higher bran yields. Bran chemical composition had a more significant impact on the milling characteristics than bran thickness. Arabinoxylans had the greatest impact on HRY, followed by lipids and proteins.ConclusionsBran thickness did not have a significant impact on the milling time, bran yield, or HRY. There was significant interaction between arabinoxylans and proteins on HRY and bran yield, which indicates the probability of crosslinking between proteins and arabinoxylans.Significance and NoveltyThis study demonstrates the importance of rice bran chemical components and their interactions in terms of rice milling quality, rather than their physical properties.
Injury to the circuit of Papez: An overlooked cause of recurrent seizures
Authors: Aker Loai , Vattoth Surjith , Paksoy Yahya 
Published: August 2023

Key Clinical MessagePapez' circuit is a unique neural pathway in the limbic system that is correlated with seizure activity. Injuries affecting Papez' circuit are often small and unusual in location but can be identifiable in MRI and functional imaging modalities, which can be helpful in the workup of refractory epilepsy.AbstractThe Papez circuit is a unique neural pathway in the limbic system of the brain. We review a patient presenting with recurrent seizures as the main manifestation of Papez' circuit pathology. The radiologic features of ischemia involving the mammillothalamic tract in Papez' circuit were correlated with the seizure activity.
A series of unfortunate events: Long‐neglected malpositioned pacemaker and its consequences
Authors: Osman Abdelrahman , Ahmad Ali 
Published: August 2023

Key Clinical MessageUse of pacemakers has increased in recent years, and they have become the premier treatment option for several arrhythmias. However, they are not without risk; this case report aims to show the importance of follow‐up and adherence to guidelines, and methods to diagnose a life‐threatening complication.
Type A aortic dissection during diagnostic coronary angiography in normal coronary arteries: A case report
Authors: Gonzalez Alena , Lin Xiongbin , Jaiswal Vikash , Shrestha Abhigan Babu , Song Yeonah , Song David 
Published: August 2023

Key Clinical MessageAortic dissection is one of the rare complication of coronary angiography. The main treatment underlies surgical intervention however; management should be done with patient's decision.AbstractCoronary angiography (CA) is a widely utilized diagnostic procedure used to evaluate blood flow through the coronary arteries and detect coronary artery disease (CAD). Despite its widespread use, it has complications including non‐life‐threatening, while there are some rare complications that can occur. We present a case of an elderly woman who presented with ST elevation myocardial infarction (STEMI) and underwent CA without evidence of CAD. However, the patient later developed type A aortic dissection (AD) as a complication of the procedure. Surgery is considered emergent treatment for type A‐AD, but the patient was asymptomatic without any complaint, shared decision making was conducted and the patient decided to pursue conservative treatment without surgical intervention. Therefore, managing AD should be tailored to each patient individually through shared‐decision making.
Mediastinal emphysema around the left carotid arteries from a toothbrush impalement injury
Authors: Ueshima Manami , Kono Yusuke 
Published: August 2023

AbstractThis report describes a case of a pediatric patient with a fever after an oral cavity injury caused by a toothbrush. On physical examination, no bleeds or injuries in his mouth were evident, but diagnostic imaging revealed wide mediastinal emphysema including the left carotid arteries. It shows the importance of carefully examining patients not to miss life‐threating conditions.
Doppler sonography in diagnosis of Bow Hunter's syndrome
Authors: Sakaida Hiroshi , Takeuchi Kazuhiko 
Published: August 2023

AbstractBow Hunter's syndrome is a rare condition in which vertebrobasilar circulatory insufficiency develops because of neck rotation. We report a patient with Bow Hunter's syndrome diagnosed by Doppler sonography. This report demonstrates the important role of Doppler sonography in diagnosis of Bow Hunter's syndrome.
Peptide‐based Organocatalyst on Stage: Functionalizing Mesoporous Silica by Tetrazine‐Norbornene Ligation
Authors: Brand Raoul D. , Busche Steffen A. , Börner Hans G. , Smarsly Bernd M. 
Published: August 2023

AbstractOrganocatalysis via the enamine mechanism developed to one of the most relevant tools in carbonyl chemistry and is widely used in asymmetric organic synthesis. In this work, a strategy is presented to conveniently immobilize a peptide‐based catalyst on silica supports for use in continuous flow catalysis reactions. A set of different porous silica supports is investigated spanning from mesoporous silica particles with defined pore sizes suitable for packed bed column reactors to silica monoliths with hierarchical meso‐macropore spaces. While the silica supports are functionalized with norbornene entities, the peptide‐based organocatalyst is modified with a tetrazine moiety, enabling the immobilization via inverse electron‐demand Diels‐Alder (IEDDA) reaction. The ligation results in catalyst loadings up to 0.2 mmol g‐1, without compromising the mesopore network. The catalytic activity of the materials is proven by the asymmetric C−C coupling reaction of n‐butanal to ß‐nitrostyrene proceeding in high yield and enantioselectivity in both batch and continuous flow setups.
N/P Co‐doped Micro‐/Mesoporous Carbons Derived from Polyvinyl Pyrrolidone–Zn0.2@ZIF‐67 with Tunable Metal Valence States towards Efficient Water Splitting
Authors: Ming Yang , Wang Yidi , Hua Jiachuan , Liu Chang , Li Jiashen , Fei Bin 
Published: August 2023

AbstractThe enhancement of electrocatalytic water splitting by modulating the intrinsic electronic environment of active sites has recently attracted lots of interest. Herein, cobalt‐cobalt oxide (CoOx) at carbons derived from metal‐organic frameworks (Zn0.2@ZIF‐67) have been modulated by using post‐phosphine (P‐CoOx/NCs), acid leaching (Co/NCs), and oxidation (O−CoOx/NCs) treatments. With the assistance of polyvinyl pyrrolidone, the resultant carbons obtain a high surface area (645.7 m2 g−1) as well as a micro‐/mesoporous system after carbonization at 920 °C. These advantages not only enhance the catalytic performance of catalysts, but also facilitate the charge transfer between interfaces towards the hydrogen evolution reaction (HER) and the oxygen evolution reaction (OER). As a result, the constructed water splitting cell fabricated with 900P‐CoOx/NCs requires a low overpotential (89 mV and 343 mV vs. reservable hydrogen electrode respectively) to drive HER and OER at 10 mA cm−2, a low cell voltage (1.69 V), and a high stability with only 4.9 % decay after 15 hours operation in the alkaline medium.
Protein Sequencing with Artificial Intelligence: Machine Learning Integrated Phosphorene Nanoslit
Authors: Mittal Sneha , Jena Milan Kumar , Pathak Biswarup 
Published: August 2023

AbstractAchieving high throughput protein sequencing at single molecule resolution remains a daunting challenge. Herein, relying on a solid‐state 2D phosphorene nanoslit device, an extraordinary biosensor to rapidly identify the key signatures of all twenty amino acids using an interpretable machine learning (ML) model is reported. The XGBoost regression algorithm allows the determination of the transmission function of all twenty amino acids with high accuracy. The resultant ML and DFT studies reveal that it is possible to identify individual amino acids through transmission and current signals readouts with high sensitivity and selectivity. Moreover, we thoroughly compared our results to those from graphene nanoslit and found that the phosphorene nanoslit device can be an ideal candidate for protein sequencing up to a 20‐fold increase in transmission sensitivity. The present study facilitates high throughput screening of all twenty amino acids and can be further extended to other biomolecules for disease diagnosis and therapeutic decision making.
Structural Insight on Supramolecular Polyion Salts: Inositol Hexaphosphate Enclosed in Cationic Macrocyclic Clusters
Authors: Pramanik Subhamay , Steinert Ryan M. , Mitchell‐Koch Katie R. , Bowman‐James Kristin 
Published: August 2023

AbstractSupramolecular macrocyclic forces have been used to trap phytate, myo‐inositol‐1,2,3,4,5,6‐hexakisphosphate, a key bioanion with multiple roles in metabolic processes. Due to the complex chemistry of six multivalent phosphates surrounding the small, cyclic inositol framework, crystallographic information of simple phytate salts has been elusive. This report represents a combined crystallographic, theoretical, and solution binding investigation of a supramolecular macrocyclic complex of phytate. Together, the results provide significant insight to phytate's intramolecular and intermolecular interactions at the microenvironment level. The macrocycle‐phytate aggregates consist of phytate anionic pairs, each partly sandwiched by two 24‐membered, amide/amine‐based cationic macrocycles. The phytate ion pairs hold the tetrameric macrocyclic array together by six strong intermolecular hydrogen bonds. Both phytates crystallize in 1a5e phosphate conformations (one axial (P2) and five equatorial phosphates). Solution NMR binding studies in 1 : 1 DMSO‐d6 : D2O indicate 2 : 1 macrocycle:phytate associations, suggesting that the sandwich‐like nature of the complex holds together in solution. DFT studies indicate the likely occurrence of dynamic intramolecular interchange of phosphate protons, as well as important roles for the axial (P2) phosphate in both intramolecular and intermolecular hydrogen bonding interactions.
Sensitization patterns to Poaceae pollen indicates a hierarchy in allergens and a lead of tropical grasses
Authors: Rodinkova Victoria , Yuriev Serhii , Mokin Vitalii , Sharikadze Olena , Kryzhanovskyi Yevhenii , Kremenska Lilia , Kaminska Olha , Kurchenko Andrii 
Published: August 2023

AbstractBackgroundThe allergenicity of pollen of Poaceae family members is a well‐known and confirmed fact. Using the data of component‐resolved molecular diagnostics of allergy, we set a goal to establish the population and individual characteristics of sensitization to grass pollen and assess the patterns of its development.MethodsMultiplex allergy Alex2 test results of 20,033 patients were used. In addition to descriptive statistics to uncover traits of the sensitized population, statistical inference was utilized to establish the conditional probability of sensitisation, the nature of links between allergens, and the most frequent combinations of allergens in individual patient profiles.ResultsSensitivity to grass pollen comprised 30.79% of the studied sample. Children accounted for 62.21%, adults—37.79%. Sensitisation to Phl p 1, Lol p 1, and Cyn d 1 was the most frequent in all age groups. Among them, Phl p 1 and Lol p 1 were the major ones. Phl p 2, Phl p 5.0101, and Phl p 6 were also responsible for primary sensitization; Phl p 5.0101 promoted the highest sIgE levels. A combination “Lol p 1—Phl p 1”, where Lol p 1 might play a leading role, was most frequent in individual profiles. Monosensitization to Phl p 2 was the second most frequent and Bayesian Network suggested its independent development. Monosensitization to Cyn d 1, especially among children, may indicate the impact of climate change, promoting the spread of the subtropical grasses to the temperate region.ConclusionsDescriptive statistics and known clinical data coincide well with statistical inference results and can provide for new clinical insights.
Depression, anxiety, and the risk of cancer: An individual participant data meta‐analysis
Authors: van Tuijl Lonneke A. , Basten Maartje , Pan Kuan‐Yu , Vermeulen Roel , Portengen Lützen , de Graeff Alexander , Dekker Joost , Geerlings Mirjam I. , Hoogendoorn Adriaan , Lamers Femke , Voogd Adri C. , Abell Jessica , Awadalla Philip , Beekman Aartjan T. F. , Bjerkeset Ottar , Boyd Andy , Cui Yunsong , Frank Philipp , Galenkamp Henrike , Garssen Bert , Hellingman Sean , Huisman Martijn , Huss Anke , de Jong Trynke R. , Keats Melanie R. , Kok Almar A. L. , Krokstad Steinar , van Leeuwen Flora E. , Luik Annemarie I. , Noisel Nolwenn , Onland‐Moret N. Charlotte , Payette Yves , Penninx Brenda W. J. H. , Rissanen Ina , Roest Annelieke M. , Ruiter Rikje , Schoevers Robert A. , Soave David , Spaan Mandy , Steptoe Andrew , Stronks Karien , Sund Erik R. , Sweeney Ellen , Twait Emma L. , Teyhan Alison , Verschuren W. M. Monique , van der Willik Kimberly D. , Rosmalen Judith G. M. , Ranchor Adelita V. 
Published: August 2023

AbstractBackgroundDepression and anxiety have long been hypothesized to be related to an increased cancer risk. Despite the great amount of research that has been conducted, findings are inconclusive. To provide a stronger basis for addressing the associations between depression, anxiety, and the incidence of various cancer types (overall, breast, lung, prostate, colorectal, alcohol‐related, and smoking‐related cancers), individual participant data (IPD) meta‐analyses were performed within the Psychosocial Factors and Cancer Incidence (PSY‐CA) consortium.MethodsThe PSY‐CA consortium includes data from 18 cohorts with measures of depression or anxiety (up to N = 319,613; cancer incidences, 25,803; person‐years of follow‐up, 3,254,714). Both symptoms and a diagnosis of depression and anxiety were examined as predictors of future cancer risk. Two‐stage IPD meta‐analyses were run, first by using Cox regression models in each cohort (stage 1), and then by aggregating the results in random‐effects meta‐analyses (stage 2).ResultsNo associations were found between depression or anxiety and overall, breast, prostate, colorectal, and alcohol‐related cancers. Depression and anxiety (symptoms and diagnoses) were associated with the incidence of lung cancer and smoking‐related cancers (hazard ratios [HRs], 1.06–1.60). However, these associations were substantially attenuated when additionally adjusting for known risk factors including smoking, alcohol use, and body mass index (HRs, 1.04–1.23).ConclusionsDepression and anxiety are not related to increased risk for most cancer outcomes, except for lung and smoking‐related cancers. This study shows that key covariates are likely to explain the relationship between depression, anxiety, and lung and smoking‐related cancers.Preregistration numberhttps://www.crd.york.ac.uk/prospero/display_record.php?RecordID=157677.
A retrospective analysis of immune checkpoint inhibitors in patients with preexisting organ dysfunction
Authors: Kesireddy Meghana , Marr Alissa , Schissel Makayla , Ganti Apar K. 
Published: August 2023

AbstractBackgroundThere are limited to no data regarding the use of immune checkpoint inhibitors (ICIs) in patients who have preexisting organ dysfunction because these patients are frequently excluded from clinical trials. The authors’ objective was to evaluate the effects of ICIs in patients with chronic kidney disease (CKD), cirrhosis, chronic obstructive pulmonary disease (COPD), and congestive heart failure (CHF).MethodsData were obtained retrospectively for patients older than 18 years with solid organ malignancies who received at least one dose of an ICI between January 1, 2015, and January 1, 2021, and had either CKD (n = 90), cirrhosis (n = 20), COPD (n = 142), or CHF (n = 82) before ICI initiation at the authors’ institution. Descriptive statistics were used to summarize patient characteristics, treatment characteristics, immune‐related adverse events (IrAEs), and outcomes. An independent samples t‐test or the Wilcoxon rank‐sum test was used to assess differences in continuous variables; the χ2 test or the Fisher exact test was used to assess differences in categorical variables between patients with and without IrAEs. Progression‐free survival (PFS) was assessed using Kaplan–Meier curves, and the log‐rank test was used to assess differences in PFS.ResultsIn all four cohorts, there were no statistically significant differences in patient characteristics, treatment characteristics, or outcomes, such as the number of hospitalizations and PFS, among those who experienced IrAEs compared with those who did not. In the CKD cohort, patients with IrAEs were significantly less likely to die than those without IrAEs (52% vs. 81% [p = .009] for all patients; 53% vs. 83% [p = .008] for patients with stage II/III disease who received no definitive local treatment and patients with stage IV disease); this difference was not observed in the cirrhosis, COPD, or CHF cohorts. There was no statistically significant difference in the number of heart failure and COPD exacerbations during the receipt of ICIs in the CHF and COPD cohorts, respectively. The incidence and time to onset of IrAEs in this study appeared to be similar to those reported previously in clinical trials that excluded patients with significant comorbidities.ConclusionsThe current results demonstrate that ICIs are well tolerated by patients who have preexisting organ dysfunction.
Photoexcited Carrier Transfer in CuInS2 Nanocrystal Assembly by Suppressing Resonant‐Energy Transfer
Authors: Hamanaka Yasushi , Okuyama Satoshi , Yokoi Rin , Kuzuya Toshihiro , Takeda Keiki , Sekine Chihiro 
Published: August 2023

AbstractHigh‐density assemblies or superlattice structures composed of colloidal semiconductor nanocrystals have attracted attention as key materials for next‐generation photoelectric conversion devices such as quantum‐dot solar cells. In these nanocrystal solids, unique transport and optical phenomena occur due to quantum coupling of localized energy states, charge‐carrier hopping, and electromagnetic interactions among closely arranged nanocrystals. In particular, the photoexcited carrier dynamics in nanocrystal solids is important because it significantly affects various device parameters. In this study, we report the photoexcited carrier dynamics in a solid film of CuInS2 nanocrystals, which is one of the potential nontoxic substitutes with Cd‐ and Pb‐free compositions. Meanwhile, these subjects have been extensively studied in nanocrystal solids formed by CdSe and PbS systems. A carrier‐hopping mechanism was confirmed using temperature‐dependent photoluminescence spectroscopy, which yielded a typical value of the photoexcited carrier‐transfer rate of (2.2±0.6)×107 s−1 by suppressing the influence of the excitation‐energy transfer.