bluuebunny/crossref_metadata_2025_split huggingface dataset:
Supervised Feature Selection to Improve the Accuracy for Malware Detection
Authors: Smith Daryle , Khorsandroo Sajad , Roy Kaushik 
Published: May 2023

Abstract
Malware is becoming increasingly sophisticated and difficult to detect with traditional monitoring tools and antivirus software. As a result, machine learning has become a popular approach for classifying and detecting malware-related data. In this study, two distinct datasets, Malware-Exploratory and CIC-MalMem-2022, were subjected to a series of supervised and unsupervised learning procedures to gather information for observation. The developed model in this research uses three clustering algorithms for analysis, namely K-Means, Density-Based Spatial Clustering of Applications with Noise, and Gaussian Mixture Model, and seven classification algorithms for predicting malware, namely Decision Tree, Random Forest, Ada Boost, KNeighbors, Stochastic Gradient Descent, Extra Trees, and Gaussian Naïve Bayes. Results show that the Malware-Exploratory dataset achieved an accuracy score of 90%, while the CIC-MalMem-2022 dataset achieved a score of 99%. Additionally, both datasets demonstrated consistency across all three clustering algorithms, indicating that variables need not be highly correlated for successful malware detection. Future studies will determine the stability of the results against feature selection and genetic algorithms.
[68Ga]-DOTATATE PET/MR-based Evaluation of Physiologic Somatostatin Receptor 2 Expression in the Adult Pituitary Gland as a Function of Age and Sex in a Prospective Cohort.
Authors: Kim Sean , Chang Se Jung Chris , Dobri Georgiana , Strauss Sara , Lin Eaton , Zavaletta Vaz , Pannullo Susan C. , Osborne Joseph R. , Schwartz Theodore H. , Knisely Jonathan P.S. , Ivanidze Jana 
Published: May 2023

Abstract
Purpose The pituitary gland has the fourth highest physiologic avidity of [68Ga]-DOTATATE. In order to guide our understanding of [68Ga]-DOTATATE PET in clinical contexts, accurate characterization of the normal pituitary gland is first required. This study aimed to characterize the normal pituitary gland using dedicated brain [68Ga]-DOTATATE PET/MRI as a function of age and sex.Methods A total of 95 patients with a normal pituitary gland underwent brain [68Ga]-DOTATATE PET examinations for the purpose of diagnosing CNS SSTR2 positive tumors (mean age: 58.9, 73% female). Maximum SUV of the pituitary gland was obtained in each patient. SUV of superior sagittal sinus was obtained to calculate normalized SUV score (SUVR) of the gland. The anatomic size of the gland was collected as maximum sagittal height (MSH). Correlations with age and sex were analyzed.Results The mean SUV and SUVR of the pituitary gland were 17.6 (range: 7-59.5, SD = 7.1) and 13.8 (range: 3.3–52.6, SD = 7.2), respectively. Older females had significantly higher SUV of the pituitary gland compared to younger females. When stratified by age and sex, both older and younger females had significantly higher pituitary SUV than older males. SUVR did not differ significantly by age or sex. MSH of the pituitary gland in younger females was significantly greater than in younger males at all age cutoffs.Conclusion This study provides an empiric profiling of the physiological [68Ga]-DOTATATE avidity of the pituitary gland. The findings suggest that SUV may vary by age and sex and can help guide the use of [68Ga]-DOTATATE PET/MRI in clinical and research settings. Future studies can build on these findings to investigate further the relationship between pituitary biology and demographic factors.
Medulloblastoma at relapse: for which patients and which tumors reirradiation is the better choice
Authors: Massimino Maura , Vennarini Sabina , Buttarelli Francesca Romana , Antonelli Manila , Colombo Francesca , Minasi Simone , Pecori Emilia , Ferroli Paolo , Giussani Carlo , Schiariti Marco , Schiavello Elisabetta , Biassoni Veronica , Erbetta Alessandra , Chiapparini Luisa , Nigro Olga , Boschetti Luna , Gianno Francesca , Miele Evelina , Modena Piergiorgio , De Cecco Loris , Pollo Bianca , Barretta Francesco 
Published: May 2023

Abstract
Background. First-line therapies for medulloblastoma(MBL) are obtaining higher survival-rates while decreasing late-effects, but treatment at relapse is not standardized. We report the experience with MBL re-irradiation(re-RT), its timing and outcome in different clinical settings and tumor groups.
Methods. Patient’s staging/treatment at diagnosis, histotypes/molecular subgroups, relapse site/s, re-treatments outcome are reported.
Results. Patients were 25, median age 11.4 years, 8 had metastases, three LCA histotype. According to 2016-2021 WHO-classification, 14 had SHH subgroup tumors(6 TP53 mutated,1 + MYC and 1 + NMYC amplification), 11 non-WNT/non-SHH (2 with MYC/MYCN amplification).Thirteen had received HART-CSI, 11 standard-CSI, one HFRT; all post-radiation chemotherapy(CT), 16 also pre-RT. Median time to relapse (local-LR in 9, distant-DR in 14, LR+DR in two) was 26 months. Fourteen patients were re-operated, in 5 excising single DR-sites, thereafter 3 received CT, two after re-RT; out of 11 not re-operated patients, 4 had re-RT as first treatment and 7 after CT. Re-RT was administered at median 32 months after first RT: focally in 20 cases, CSI in 5, never resulting in radionecrosis. Median post-relapse-PFS/after re-RT were 16.7/8.2 months, while overall survival-OS were 35.1/23.9 months, respectively. Metastatic status both at diagnosis/relapse negatively affected outcome and re-surgery was prognostically favorable.MYC,MYCN,P53 status and molecular subgroups, RT extension/fractionation, gender and age were not statistically prognostic; in the multivariable model, OSs were positively influenced by longer intervals before re-RT, re-surgery and not-SHH subgroups (P=0.019 from recurrence and 0.004 from second RT).
Conclusions. Re-surgery+reRT can prolong survival; a substantial fraction of patients with worse outcome belongs to SHH-subgroup.
Prevalence and Imaging-Based Classification of Pituitary Adenomas with Hard Consistency: A Systematic Review and Meta-Analysis
Authors: Gaia Felipe , Pokorny Gabriel , Cortez Gustavo M , Zymberg Samuel Tau , Cruz Oswaldo Laércio Mendonça 
Published: May 2023

Abstract
OBJECTIVE Transsphenoidal resection of pituitary adenomas can be challenging in patients with tumors with a hard consistency. We performed a systematic review and meta-analysis of the literature to identify the true incidence and the performance of radiological findings in identifying pituitary adenomas with a hard consistency.METHODS A literature search was conducted and included studies that compared intraoperative pituitary tumor consistency and pre-operative magnetic resonance imaging (MRI). Using random-effects meta-analysis and univariate analysis, we evaluate the prevalence of hard pituitary tumors.RESULTS Of studies the 916 studies, 888 studies were excluded. Finally, 28 studies harboring 1116 patients with pituitary tumors were included. Of them, hard-consistency tumors were intraoperatively adjudicated in 219 patients (weighted incidence of 16,82%,95% CI, 12.35–22.48%; I2 = 65,1%). Seventeen (60%) reported a relation between radiological findings and intraoperative tumor consistency in at least one MRI sequence, with a weighted proportion of 15%, 95% CI, 10,31% − 22,70%). Apparent diffusion correlation(ADC), and T2-weighted sequences were associated with tumor consistency in 31% and 53% of the studies, respectively. Nonetheless, conflicting signal intensities across the studies precluded conventional MRI sequences from accurately predicting pituitary tumor consistency.CONCLUSION The weighted incidence of pituitary tumors adjudicated as having a hard consistency was 16% in the present sample of studies.
Modeling of Enhanced Oil Recovery Using Nanofluid
Authors: Godiwal Rishabh , Mandal Monisha Mridha 
Published: May 2023

Abstract
The demand for energy has been increasing exponentially and at present time, this cannot be fulfilled by renewable energy alone. Crude oil has remained one of the major mineral resources for energy. It is difficult for a populated developing country like India, to keep a balance between the supply and demand of crude oil. In recent years, considerable studies have beenconducted to search for efficient technologies for recovering oil from old oil reservoirs since about two-thirds of the oil in the reservoir cannot be recovered by conventional methods. The trapped oil in the reservoir can be recovered by enhanced oil recovery (EOR) methods such as chemical, thermal, gas, and microbial methods. Nanofluid flooding is found to be one of the efficient methods that have gained importance as nanoparticles have been found to alter the rock wettability which helps in oil recovery. It has also been found that the use of modeling to evaluate the performance of any process before conducting any experiments is found to be a more economical and effective practice. Therefore, the present modeling work was carried out to explore the application of nanofluid in EOR using COMSOL Multiphysics. This study investigates the effect of different parameters on EOR such as the addition of nanoparticles (Al2O3) in water, the porosity of the reservoir, and diffusion coefficients of nanofluid on oil saturation in reservoirs. Velocity contours, temperature contours, and oil saturation contours within the reservoir were investigated. In the future, this model may be used to screen the performance of other nanofluids or chemical agents.
Novel VHL Germline Mutations in Iranian RCH Patients
Authors: Naseripour Masood , Bagherzadeh Kowsar , Khakpoor Golnaz Golnaz , Sedaghat Ahad , Mirshahi Reza , Kasraei Hengameh , Kiaee Reza Afshar , Azimi Fatemeh 
Published: May 2023

Abstract
Von Hippel-Lindau (VHL) syndrome is an autosomal dominant inherited multisystem neoplasia disorder caused by the VHL tumor suppressor gene, coding for VHL protein (pVHL), variants. Various types of VHLvariants present different clinical phenotypes that later lead to events resulting in benign or malignant lesions including Retinal Capillary Hemangioblastoma (RCH).
In this case series study, 3 families (5 RCH patients) with novel mutations were included. VHL mutational analysis was performed by Sanger sequencing. We reported on 3 novel mutation sites, including c.511A>C, c.514C>T, and c.511A>T in exon 3 of the VHL gene. According to the ACMG classifications, c.514C>T and c.511A>T variations are likely pathogenic, and c.511A>C is a variant of uncertain significance (VUS) and in accordance with autosomal dominant inheritance. The location and impact of the incidence mutations on pVHL were computed using in silico analysis. The obtained structural information and computational analysis showed that the studied mutations induce conformational changes that limit the flexibility of the pVHL interaction interface with elonginB/C, elongin C/B, and cullin2, which is necessary for HIF1 alpha binding. The recently added gene variants and their related clinical phenotypes will improve the VHL diagnosis accuracy and the patients’ population carrying VHLgene mutations. These pioneering results could be a model for future functional studies.
Field deployable automated nucleic acid extraction system enables rapid on-site measurement of microbial diversity of Yellowstone National Park hot springs
Authors: Wood Jason M. , Urbaniak Camilla , Parker Ceth W. , Singh Nitin Kumar , Wong Season , Arumugam Arunkumar , Skorupa Dana , Hemmah Ashlyn , Laaguiby Phoebe , Karouia Fathi , Peyton Brent , Tighe Scott , VENKATESWARAN KASTHURI 
Published: May 2023

Abstract
Background: Microbial diversity estimation relies heavily on the extraction of nucleic acids from complex sample matrixes, regardless of the location of the laboratory used to recover the DNA, including those on Earth or in space. Nucleic acid sample preparation steps are labor intensive and require the effective lysis of cells and recovery of pure inhibitor free purification prior to downstream applications. An automated system is desirable for field deployment because easy of use and autonomous rapid results. This extends to use in remote filed locations by NASA for the in situ measurements of life. The goal of this study was to setup a field-deployable lab in a remote setting with limited resources and demonstrate the ability to process and sequence nucleic acid samples on-site. Microbial mat and sediment samples were collected from several hot springs in Yellowstone National Park (YNP), targeting the Five Sister Springs (FSS), spring LNN010, and Octopus Spring (OS). Samples were processed on site and analyzed for microbial diversity using the field-deployable lab instrument.
Results: Microbial diversity measured with both the Illumina (short reads) and Oxford Nanopore Technology (ONT; long reads) sequencing systems was highly similar. In general, for both the FSS and OS hot spring sites, bacteria (>90%) dominated over archaea (<10%). Metagenomic results were binned to existing databases such that the taxonomic ID represents the closest known organism with a sequenced genome. With this caveat the presence of, the most common archaeal community member in both the mat and sediment was related to Candidatus Caldiarchaeum subterraneum. Among the bacterial members, Roseiflexus sp. RS-1 was found to be highly abundant in the mat environment, as already reported. Notably, however, organisms related to Bacterium HR17 was abundant several FSS/OS mat samples. The detection of this novel bacterial community member warrants additional research.
Conclusion: This is the first study to deploy an automated nucleic acid extraction system in YNP) to rapidly (~8 to 9 hrs) measure the environmental microbiome of hot springs. The demonstration of a field deployable system for nucleic acids extraction from complex materials (mats and sediments) highlights its utility not only in extreme environments on Earth but its potential benefit to NASA and deployment in space, once performance under microgravity is refined. The benefits of this new field-deployable lab include sample processing (extracting nucleic acids), shotgun metagenome library preparation, and sequencing utilizing the space-tested Nanopore sequencing platform.
Most effective counter measure for Castryck-Decru attackagainst SIDH-Isogeny Problems with masked torsion point images
Authors: R Krishnaprabha 
Published: May 2023

Abstract
One of the newest areas in post-quantum cryptography is isogeny-based cryptography.Collisionresistant hashing and key exchange are two crucial issues in Post Quantum cryptography that arebased on isogeny.Finding an isogeny between two supersingular elliptic curves formed over a finitefield Fq is the challenge in isogeny-based encryption. Finding End(E1) and End(E2) is the issuethat this problem is comparable to.It is claimed that supersingular isogeny Diffie Hellman (SIDH)key exchange is quantum safe.In this instance, we take advantage of the endomorphism ring’s non-commutative property.Both the initiator and the response contribute equally to the sharedsecret in SIDH.Here, both public and private keys are created and sent through an unsecuredchannel.Finding isogenies between supersingular elliptic curves is the fundamentally difficult task.To calculate the necessary isogeny, we use information about torsion points and the degree of the secret isogeny.
Heteroseksual sebagai Politik Identitas: Kajian Sosio-ideologi Larangan Homoseksual dalam Imamat 18:22 melalui Perspektif LGBT
Authors: Sihotang Albert Parsaoran 
Published: May 2023

AbstractThis article offers a different interpretation of Leviticus 18:22, which has traditionally been seen as a scripture that forbids homosexuality. The Bible outright condemns various sexual orientations such as homosexuality, bisexuality, and bestiality; as a result, the Old Testament portrays heterosexuality as the proper sexual identity. The general reading of texts frequently devolves into pros and contras but leaves little room for other aspects of the text that can allow for a more transformative interpretation. In fact, when texts and the reality of today’s plurality in sexual orientations collide, dominant and judgmental meanings often result. Due to this, socio-ideological studies reread Leviticus 18:22 from an LGBT viewpoint in order to shed light on the Priest’s Tradition’s ideological role in promoting heterosexuality as its identity politics. This analysis gives space to the sociopolitical situation that gives the book its shape, departing fromawareness and skepticism of the existence of other realities that are not described or even repressed in the text (behind the text). Hence, it is hoped that the text’s true meaning, one that liberates prejudice via conversation and creativity, might be recovered.
AbstrakArtikel ini memberikan pembacaan alternatif terhadap teks Imamat 18:22 yang selama ini cenderung dipahami sebagai teks yang mengecam homoseksual. Teks secara eksplisit menolak beragam orientasi seksual seperti homoseksual, biseksual, bestialitas; dan dengan demikian menggambarkan heteroseksual sebagai identitas seksual yang benar dalam Perjanjian Lama. Pembacaan umum terhadap teks acap kali sekadar jatuh pada persoalan pro-kontra, namun tidak memberikan ruang terhadap dimensi lain dari teks yang mungkin memberikan pembacaan yang lebih transformatif. Sebab dalam faktanya, perjumpaan teks dengan realitas keberagaman orientasi seksual di masa kini cenderung memberikan makna yang menghegemoni dan menghakimi. Untuk itu, kajian sosio-ideologis berupaya menguak peran ideologis dari Tradisi Imam yang mempropagandakan heteroseksual sebagai politik identitasnya, serta membaca ulang teks Imamat 18:22 melalui perspektif LGBT. Berangkat dari kesadaran dan kecurigaan akan adanya realitas lain yang tidak digambarkan bahkan dibungkam dalam teks, kajian ini memberikan ruang terhadap situasi sosial-politik yang membentuk teks (di balik teks). Dengan demikian, diharapkan tercapai pemulihan makna dari teks yang membebaskan prasangka secara jujur, dialogis, dan kreatif.
Hydraulic optimization simulation for reducing confluence and controlling the overflow pollution of storage ponds based on the Storm Water Management Model and Non-dominated Sorting Genetic Algorithm-II
Authors: Jin Cuntian 
Published: May 2023

Abstract
The Storm Water Management Model (SWMM) was established to simulate rainfall–runoff dynamically, and the internal runoff component of the SWMM was used to simulate rainfall operation in each watershed, including rainfall–runoff and scour pollution load. Then, using the routing component in the SWMM, the properties of runoff into the tank system are calculated through pipelines and other facilities to obtain the optimal tank volume. The coupling optimization model was established, and the algebraic function of the storage capacity, total runoff, and total cost was established by using the multiple linear regression method, which was transformed into the optimization model aiming at the minimum total runoff and total cost. The NSGA-II is improved by using a reverse learning mechanism. By solving the optimization model, the non-dominant solution of the proxy model is obtained. The non-dominant solution was substituted into the SWMM, and the rationality of the optimization results was analyzed. The experimental results show that the reservoir volume determined by this method can effectively accept the pollutants brought by the initial rain, so as to reduce the hydraulic pollution caused by the confluence overflow and the overflow pollution of the urban integrated pipe network.
Planted drying beds in the African context: state of knowledge and prospects
Authors: Goussanou Baruc Kpèhouénou , Akowanou Akuemaho Virgile Onésime , Deguenon Hontonho Espérance Justine , Daouda Mohamed Moukorab Arêmou , Djihouessi Metogbe Belfrid , Aina Martin Pépin , Labanowski Jérôme 
Published: May 2023

Abstract

In low-income countries, the discharge of untreated fecal sludge directly into the environment is a common practice that poses a threat to both environmental and public health. Planted drying beds (PDBs) are a promising and low-cost option for treating fecal sludge. Therefore, in Africa, the use of PDBs for treating fecal sludge is increasingly valuable due to the technology's high efficiency, especially in tropical climates. This paper presents a literature review on the use of PDBs for treating fecal sludge in Africa, focusing on current research requirements and directions. This review shows that Echinochloa pyramidalis appears to be the most effective indigenous species used for this purpose, while also highlighting the lack of stability in the design and implementation models of PDBs. Standardizing and generalizing implementation methodologies for PDBs in Africa, researching new native and efficient species, and testing combinations of different species in the beds would all be beneficial.
ETYCZNO-MORALNE DETERMINANTY WPISU NA LISTĘ ADWOKATÓW W POGLĄDACH JUDYKATURY`
Authors: Dytko Jan 
Published: May 2023

Adwokat to zawód zaufania publicznego. Adwokata z klientem łączy szczególnego typu relacja. Klient powierza adwokatowi ważne informacje ze swojego życia i postępowania, w zamian oczekując pomocy prawnej. Postawę adwokata w stosunku z klientem, ale także w życiu codziennym powinny cechować szacunek i zaufanie.
Nie każdy prawnik może zostać adwokatem. Oprócz warunków formalnych przewidzianych ustawą adwokata powinien cechować nieskazitelny charakter oraz dotychczasowe nienaganne zachowanie, które łącznie gwarantują rękojmię należytego wykonywania zawodu.
Przez rękojmię prawidłowego wykonywania zawodu adwokata należy rozumieć taki zespół cech charakteru i zachowań w sferze zawodowej i prywatnej, które składają się na wizerunek osoby, na której nie ciążą żadne zarzuty podważające jej wiarygodność.
Rękojmia uznawana jest jako uroczyste poręczenie, zapewnienie, że z racji posiadanych cech zawód zaufania publicznego będzie wykonywany prawidłowo. Zakres znaczeniowy rękojmi prawidłowego wykonywania zawodu wyznaczają dwa czynniki: pierwszy z nich dotyczy charakteru osoby ubiegającej się o wpis na listę adwokatów, drugi – kompetencji w posługiwaniu się regułami zawodowymi. Miernikiem rękojmi powinny być umiejętności praktyczne kandydata ubiegającego się o wpis na listę adwokatów, przez które należy rozumieć doświadczenie zdobyte w świadczeniu pomocy prawnej.
Rękojmia do wykonywania zawodu to warunkujący ją przez ustawodawcę„nieskazitelny charakter” i „dotychczasowe zachowanie kandydata”, a zatem cechywartościujące konkretną osobę nie w sferze intelektualnej i profesjonalnej, leczwyłącznie etyczno-moralnej. Brak rękojmi należytego wykonywania zawoduadwokata jest implikacją braku nieskazitelnego charakteru i dotychczasowegozachowania odpowiadającego ocenom moralnym i etycznym. Są to pojęcia jednolite i niepodzielne.
Celem niniejszego opracowania jest prezentacja oraz analiza owej rękojmi. Autor posługuje się językiem prawnym i prawniczym. Cytuje przepisy prawa oraz poglądy doktryny i judykatury. Tą ostatnią w przeważającej większości. Orzecznictwo dominuje w wypowiedziach autora. Tym sposobem autor prezentuje ukształtowaną linię orzecznictwa sądowego w materii objętej tematem opracowania.