bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genome maintenance meets mechanobiology
Authors: Spegg Vincent , Altmeyer Matthias 
Published: August 2023

AbstractGenome stability is key for healthy cells in healthy organisms, and deregulated maintenance of genome integrity is a hallmark of aging and of age-associated diseases including cancer and neurodegeneration. To maintain a stable genome, genome surveillance and repair pathways are closely intertwined with cell cycle regulation and with DNA transactions that occur during transcription and DNA replication. Coordination of these processes across different time and length scales involves dynamic changes of chromatin topology, clustering of fragile genomic regions and repair factors into nuclear repair centers, mobilization of the nuclear cytoskeleton, and activation of cell cycle checkpoints. Here, we provide a general overview of cell cycle regulation and of the processes involved in genome duplication in human cells, followed by an introduction to replication stress and to the cellular responses elicited by perturbed DNA synthesis. We discuss fragile genomic regions that experience high levels of replication stress, with a particular focus on telomere fragility caused by replication stress at the ends of linear chromosomes. Using alternative lengthening of telomeres (ALT) in cancer cells and ALT-associated PML bodies (APBs) as examples of replication stress-associated clustered DNA damage, we discuss compartmentalization of DNA repair reactions and the role of protein properties implicated in phase separation. Finally, we highlight emerging connections between DNA repair and mechanobiology and discuss how biomolecular condensates, components of the nuclear cytoskeleton, and interfaces between membrane-bound organelles and membraneless macromolecular condensates may cooperate to coordinate genome maintenance in space and time.
Medienkompetenz in Familien
Authors: Hantinger Marion 
Published: August 2023

ZusammenfassungDie Verwendung von Medien in Familien ist ein wichtiges Thema in der heutigen Gesellschaft, da immer mehr Familien auf digitale Medien wie Smartphones, Tablets, Computer und Fernseher zugreifen. Familien sollten Regeln und Richtlinien für die Verwendung von Medien aufstellen. Eltern sollten als Vorbilder agieren und selbst verantwortungsbewusst mit Medien umgehen, um ihre Kinder zu ermutigen, dies ebenfalls zu tun. Die Aufgabe der Fachkräfte, die mit Familien arbeiten, ist es, die Eltern auf diese Herausforderung vorzubereiten und begleitend zu unterstützen. Bildungs- und Ausbildungsprogramme können ebenfalls eine wichtige Rolle bei der Förderung der Medienkompetenz spielen.
Root-analogue implants compared to forced orthodontic extrusion: a retrospective analysis of clinical, radiological and esthetic outcomes after restoration
Authors: Böse Mats Wernfried Heinrich , Beuer Florian , Naumann Michael , Spies Benedikt Christopher , Neumeyer Stefan , Hildebrand Detlef , Bruhnke Maria 
Published: August 2023

Abstract
Objectives
To assess clinical, radiological and esthetic outcomes of restorations supported by root-analogue implants (RAIs) or roots of severely damaged teeth after forced orthodontic extrusion (FOE).

Materials and methods
Clinical data regarding milled one-piece (titanium/zirconia roots and zirconia abutments) RAIs (REPLICATE™ System) and FOE were recorded and retrospectively evaluated for 40 patients by two investigators. Strict inclusion and exclusion criteria were applied. Functional and esthetic outcomes were assessed for n = 20 pre-molars and n = 20 anterior teeth via comparison of radiographic and digital images applying the novel Functional Implant Prosthodontic Score (FIPS). Krippendorff’s alpha coefficient was calculated to assess inter-rater reliability. Mann–Whitney-U-Test was used to compare the assessed parameters. Level of significance was set to p < 0.05.

Results
After a mean observation period of 18.4 ± 5.7 months for restorations supported by RAIs and 43.9 ± 16.4 months for restorations after FOE, mean FIPS scores were 9.2/8.8 ± 1.1/1.2 (RAIs) and 7.4/7.7 ± 1.3/1.5 (FOE), respectively. Krippendorff’s alpha coefficients did not reveal unacceptable inter-rater reliabilities regarding the investigators and applicability of FIPS. Significant differences were documented when comparing restorations after FOE or supported by RAIs regarding bone loss (p < 0.01), presence of papillae (p < 0.05) and quality and quantity of mucosa (p < 0.02) in favor of FOE.

Conclusions
Within the main limitations of sample size and the retrospective study design, both concepts seem to provide clinically acceptable results.

Clinical relevance
Bone- and tissue-preserving characteristics regarding the concept of FOE are promising. It could be applicable for socket preservation and subsequent conventional implant placements in an adapted workflow.
On the mixed connectivity conjecture of Beineke and Harary
Authors: Johann Sebastian S. , Krumke Sven O. , Streicher Manuel 
Published: August 2023

AbstractThe conjecture of Beineke and Harary states that for any two vertices which can be separated by k vertices and l edges for $$l\ge 1$$

l
≥
1

but neither by k vertices and $$l-1$$

l
-
1

edges nor $$k-1$$

k
-
1

vertices and l edges there are $$k+l$$

k
+
l

edge-disjoint paths connecting these two vertices of which $$k+1$$

k
+
1

are internally disjoint.In this paper we prove this conjecture for $$l=2$$

l
=
2

and every $$k\in \mathbb {N}$$

k
∈
N

.We utilize this result to prove that the conjecture holds for all graphs of treewidth at most 3 and all k and l.
Incidental Adaptation: The Role of Non-climate Regulations
Authors: Bento Antonio M. , Miller Noah , Mookerjee Mehreen , Severnini Edson 
Published: August 2023

AbstractWhen a non-climate institution, policy, or regulation corrects a pre-existing market failure that would be exacerbated by climate change, it may also incidentally induce climate adaptation. This regulation-induced adaptation can have large positive welfare effects. We develop a tractable analytical framework of a corrective regulation where the market failure interacts with climate, highlighting the mechanism of regulation-induced adaptation: reductions in the climate-exacerbated effects of pre-existing market failures. We demonstrate this empirically for the US from 1980 to 2013, showing that ambient ozone concentrations increase with rising temperatures, but that such increase is attenuated in counties that are out of attainment with the Clean Air Act’s ozone standards. Adaptation in nonattainment counties reduced the impact of a 1 °C increase in climate normal temperature on ozone concentration by 0.64 parts per billion, or about one-third of the total impact. Over half of that effect was induced by the standard, implying a regulation-induced welfare benefit of $412–471 million per year by mid-century under current warming projections.
The Role of Mental Effort in Students’ Perceptions of the Effectiveness of Interleaved and Blocked Study Strategies and Their Willingness to Use Them
Authors: Janssen Eva M. , van Gog Tamara , van de Groep Laura , de Lange Anne Jóia , Knopper Roosmarijn L. , Onan Erdem , Wiradhany Wisnu , de Bruin Anique B. H. 
Published: August 2023

AbstractStudents tend to avoid effective but effortful study strategies. One potential explanation could be that high-effort experiences may not give students an immediate feeling of learning, which may affect their perceptions of the strategy’s effectiveness and their willingness to use it. In two experiments, we investigated the role of mental effort in students’ considerations about a typically effortful and effective strategy (interleaved study) versus a typically less effortful and less effective strategy (blocked study), and investigated the effect of individual feedback about students’ study experiences and learning outcomes on their considerations. Participants learned painting styles using both blocked and interleaved studying (within-subjects, Experiment 1, N = 150) or either blocked or interleaved studying (between-subjects, Experiment 2, N = 299), and reported their study experiences and considerations before, during, and after studying. Both experiments confirmed prior research that students reported higher effort investment and made lower judgments of learning during interleaved than during blocked studying. Furthermore, effort was negatively related to students’ judgments of learning and (via these judgments) to the perceived effectiveness of the strategy and their willingness to use it. Interestingly, these relations were stronger in Experiment 1 than in Experiment 2, suggesting that effort might become a more influential cue when students can directly compare experiences with two strategies. Feedback positively affected students’ considerations about interleaved studying, yet not to the extent that they considered it more effective and desirable than blocked studying. Our results provide evidence that students use effort as a cue for their study strategy decisions.
Dimensions of Warm Parenting Attributions Differentiate Conduct Problem Subtypes in Young Children
Authors: Kaouar Silvana , Fleming Georgette E. , Neo Bryan , Hawes David J. , Eapen Valsamma , Kimonis Eva R. 
Published: August 2023

AbstractUnderstanding the developmental psychopathology of child conduct problems (CP) has been advanced by differentiating subtypes based on levels of internalizing problems (INT) and/or callous-unemotional (CU) traits (i.e., low empathy/guilt, poor motivation, shallow/deficient affect). The current study sought to elucidate prior inconsistencies in the role of warm/positive and harsh/negative parenting subcomponents in CP by differentiating subtypes on the basis of INT and CU traits. Parents of 135 young children (M age = 4.21 years, SD = 1.29) referred to specialty clinics for the treatment of CP completed pre-treatment measures of parenting and rated their child’s levels of CP, INT, and CU traits. Results of planned comparisons revealed that mothers of children classified as secondary CU variants (high CU/ high INT) reported fewer overall warm attributions toward their child, compared with CP-only (low CU) children. They also reported a more negative dyadic relationship characterized by feelings of anger/hostility, active avoidance and/or a desire to do harm to their child relative to primary CU variants (high CU/ low INT). Mothers of primary CU variants attributed fewer good and altruistic intentions towards others in their child, relative to CP-only children. Subtypes were undifferentiated on observed positive and negative parenting behaviors, indicative of a disconnect between parenting behaviors and cognitions for mothers of children high on CU traits. Findings are discussed in relation to their theoretical and practice implications, and in guiding future research.
Temperature stability of Co/Pt and Co/Pd synthetic antiferromagnets using an Ir spacer
Authors: Caseiro M. , Macedo R. , Araujo P. D. R. , Cardoso S. , Erkovan M. , Freitas P. P. 
Published: August 2023

AbstractThe magnetic properties of Co/Pt and Co/Pd multilayers of perpendicular synthetic antiferromagnets with an Ir spacer were investigated. A strong interlayer exchange coupling of $$J_{\mathrm{{ex}}}=2.01$$

J
ex

=
2.01

$$\mathrm{{erg/cm}}^2$$

erg
/
cm

2

was observed in the Co/Pt-based structures and a lower value of $$J_{\mathrm{{ex}}}=1.04$$

J
ex

=
1.04

$$\mathrm{{erg/cm}}^2$$

erg
/
cm

2

was found in the Co/Pd multilayers. Only the former revealed a high post-annealing stability at $$T_a=330\,^{\circ }$$

T
a

=
330

∘

C, as the latter exhibited a ferromagnetic coupling most likely due to the deterioration of the spacer by pinhole coupling. This assumption was confirmed by theoretical calculations of the total energy functional. Moreover, the high temperature stability of Ir-based Co/Pt p-SAF structures was verified by calculating the exchange field $$H_{\mathrm{{ex}}}$$

H
ex

from magnetization M(H) loops as a function of temperature, where it reached a temperature of $$T_b=370\,^{\circ }$$

T
b

=
370

∘

C before losing all interlayer exchange coupling.
Metabolic phenotyping in people living with obesity: Implications for dietary prevention
Authors: Blaak Ellen E. , Goossens Gijs H. 
Published: August 2023

AbstractGiven the increasing number of people living with obesity and related chronic metabolic disease, precision nutrition approaches are required to increase the effectiveness of prevention strategies. This review addresses these approaches in different metabolic phenotypes (metabotypes) in obesity. Although obesity is typically associated with an increased cardiometabolic disease risk, some people with obesity are relatively protected against the detrimental effects of excess adiposity on cardiometabolic health, also referred to as ‘metabolically healthy obesity’ (MHO). Underlying mechanisms, the extent to which MHO is a transient state as well as lifestyle strategies to counteract the transition from MHO to metabolically unhealthy obesity (MUO) are discussed. Based on the limited resources that are available for dietary lifestyle interventions, it may be reasonable to prioritize interventions for people with MUO, since targeting high-risk patients for specific nutritional, lifestyle or weight-loss strategies may enhance the cost-effectiveness of these interventions. Additionally, the concept of tissue insulin resistant (IR) metabotypes is discussed, representing distinct etiologies towards type 2 diabetes (T2D) as well as cardiovascular disease (CVD). Recent evidence indicates that these tissue IR metabotypes, already present in individuals with obesity with a normal glucose homeostasis, respond differentially to diet. Modulation of dietary macronutrient composition according to these metabotypes may considerably improve cardiometabolic health benefits. Thus, nutritional or lifestyle intervention may improve cardiometabolic health, even with only minor or no weight loss, which stresses the importance of focusing on a healthy lifestyle and not on weight loss only. Targeting different metabotypes towards T2D and cardiometabolic diseases may lead to more effective lifestyle prevention and treatment strategies. Age and sex-related differences in tissue metabotypes and related microbial composition and functionality (fermentation), as important drivers and/or mediators of dietary intervention response, have to be taken into account. For the implementation of these approaches, more prospective trials are required to provide the knowledge base for precision nutrition in the prevention of chronic metabolic diseases.
Research trends and frontiers in lupus nephritis: a bibliometric analysis from 2012 to 2022
Authors: Qi Jiaping , Wu Teng , Wang Jing , Zhang Ju , Chen Lin , Jiang Zhaoyu , Li Yixuan , Jiang Huan , Sun Qiong , Gu Qingchen , Ying Zhenhua 
Published: August 2023

Abstract
Objectives
Lupus nephritis is a prevalent renal manifestation of systemic lupus erythematosus (SLE) and represents a significant cause of morbidity and mortality associated with the disease. This study endeavors to undertake a meticulous bibliometric analysis of LN publications to comprehend the research hotspots and future directions.

Methods
The literature on LN was acquired from the Web of Science Core Collection (WoSCC). Co-occurrence and cooperative relationship analysis of authors, institutions, countries, journals, references and keywords in the publication was performed through CiteSpace, VOSviewer and a bibliometric online analysis platform. The knowledge graphs were created, and clustering and emergence analyses were performed.

Results
According to the search strategy, a total of 2077 publications related to lupus nephritis (LN) have been identified, with China being the largest contributor globally. The Ohio State University emerged as the most prolific institution. Lupus is the most cited and published journal. Jan J Weening and Brad Rovin were the most prolific and cocited authors. The current research focus revolved around the “nirp3 inflammasome,” “biomarker,” and “voclosporin”. “international society,” “thrombotic microangiopathy (TMA),” and “pathway” were identified to be future research hotpots by keyword burst analysis.

Conclusions
This bibliometric analysis summarizes for the first time the progress of LN research (2012–2022), and qualitatively and quantitatively evaluates the bibliometric information of LN research. There has been a steady increase in the scientific literature on LN over the past 11 years, with an average growth rate of 7.27%. In this field, researchers are primarily based in China and the United States. The pathogenic mechanisms, management strategies and prognostic outcomes of LN are acknowledged as prospective research hotspots. Bibliometrically, the research status and trends of LN publications may greatly assist and be a significant reference for future research in the area.
Tracking contaminants of concern in wet-weather sanitary sewer overflows
Authors: Besley Colin H. , Batley Graeme E. , Cassidy Michele 
Published: August 2023

AbstractFour representative sites in the greater city of Sydney, Australia, were selected for a study of the wet-weather overflow of sanitary (separate to stormwater) sewerage systems. Water samples were collected by autosamplers from up to eight wet weather overflow events over 16 months and from companion receiving water sites. The objective was to identify the risks posed by sewage contaminants to aquatic biota in the receiving waters, to aid in prioritising management actions. Twelve organic contaminants were identified in influents across the four sites under rainfall ingress diluted conditions, with measurements showing that the highest concentrations were restricted to the anti-inflammatory acetaminophen and the diabetes medication metformin. Lesser contaminants included theobromine, ibuprofen, sucralose, and three benzotriazoles (mainly 1-H benzotriazole). An assessment of the toxicity of the identified organic chemicals indicated that none appeared to pose concerns for ecosystem health before wet-weather ingress dilution, and this was even less likely after dilution in the receiving waters. Metal concentrations were low; however, ammonia concentrations in the influent did pose a risk to ecosystem health, although receiving water dilution diminished this risk at four of the five receiving water locations studied.
Dreamland—a dream content questionnaire in German based on the English version
Authors: Ableidinger Severin , Klösch Gerhard , Holzinger Brigitte 
Published: August 2023

AbstractIn dream research there exists a multitude of dream questionnaires and dream content analysis scales. However, many of them are either limited, not standardized or validated, or require a lot of effort. At the same time there are often divergent or even contradictory results in dream research, and comparability between different studies is often limited. Large sample sizes are rare but would be necessary for representative and compelling findings. For studies analyzing large samples of dreams, short and easy-to-use questionnaires would be of great assistance. As an easy-to-use questionnaire that covers all relevant dream aspects, the Dreamland Questionnaire, was developed in 1997. The questionnaire has since been revised and partially validated. In this paper, we give an overview of the questionnaire and its underlying methodology. The questionnaire is separated into three parts measuring dream quantities and dream qualities as well as lucidity. The questionnaire further encourages the dreamer to write down their dream. In different studies it has already been used to show that dreams sampled in the laboratory and dreams sampled at home differ and that emotionality in dreams differs if rated by the dreamer themselves or by external raters. The questionnaire is also available in German.
Design and analysis of performance for wider field of view of concentrator
Authors: Zheng Hongqing , Jiang Yuesong , Cheng Wei , Cai Fan 
Published: August 2023

AbstractA novel wider field of view of concentrators, which is composed of an optical fisheye lens with wider field of view and a traditional compound parabolic concentrator (CPC), is proposed in this paper. In this novel concentrator, exits of rays of meniscus fisheye lens and entrances of rays of CPC is fitted tightly on the basis of principles of ray trace, so that the proposed concentrator can be used to concentrate higher optical power than traditional CPC. In this paper, based on the geometry construction model of the new wide-field concentrator is established, the optics simulation software of TracePro is employed to model and design the structure of the concentrator, and analyses of performances for the concentrator is also carried out. The results show that this new wide-field concentrator can significantly increase the light energy received by the concentrator compared with a conventional concentrator without a wide-field fisheye lens, and can significantly improve the performance of LED wireless optical communication systems if used in the receiving optical antenna of LED wireless optical communication systems.
Identification and Environmental Assessments for Different Scenarios of Repurposed Decommissioned Wind Turbine Blades
Authors: Johst P. , Kucher M. , Bühl M. , Schulz P. , Kupfer R. , Schilling L. , Santos R. M. , Carneiro C. , Voigt P. , Modler N. , Böhm R. 
Published: August 2023

AbstractThe rapidly growing wind industry poses a fundamental problem for wind turbine blade (WTB) disposal in many areas of the world. WTBs are primarily manufactured from composites consisting of a thermoset matrix and reinforcing fibers. Currently, there are no economically viable recycling technologies available for such large-scale composite products. Thus, other treatment strategies for disposed WTBs have to be considered. This study explores the repurpose of WTBs as a promising alternative approach from a processual and technological point of view. For this purpose, the study is guided by the categorization into four different types of repurposed applications: high-loaded complete structure (T1), low-loaded complete structure (T2), high-loaded segmented structure (T3), and low-loaded segmented structure (T4). A three-dimensional CAD model of an Enercon-40/500 (E40) wind turbine blade is derived in a reverse engineering procedure to obtain knowledge about the actual geometry of the WTB. Based on the design, three ecosystems of product scenarios (S) with different manufacturing technologies involved are investigated: a climbing tower (S1), a playground (S2) and the combination of a photovoltaic (PV)-floating pontoon, and a lounger (S3). A screening life cycle assessment (LCA) is conducted to evaluate the three repurposed scenarios according to environmental aspects. It is shown that the repurpose of E40 WTB composite material can reduce the environmental impact and leads to significant resource savings in relation to a reference product of similar quality. A particularly high saving potential is identified for the substitution of emission-intensive materials in construction applications. Furthermore, it is found that transport processes are the primary contributor to the environmental impact of repurposed applications.