bluuebunny/crossref_metadata_2025_split huggingface dataset:
Review on Paclitaxel Derivatization: Enhanced Anticancer Action
Authors: Shrivastava Nansi , Mishra Rakhi , Tiwari Prashant , Singh Ayushi 
Published: March 2023

Background:
The United States Food and Drug Administration (FDA) has authorized
paclitaxel for the treatment of numerous types of cancer, including breast, lung, ovarian, and Kaposi's
sarcoma. It possesses all the characteristics of BCS class IV medications, including low bioavailability,
low water solubility, poor permeability, unpredictable and poor absorption, and inter- and intrasubject
variability.

Objective:
The purpose of this research was to evaluate previous efforts done to derivatize paclitaxel for
greater effectiveness.

Methods:
A systematic literature review was conducted from a variety of sources, including published
research, review articles, and patents, that mainly focus on the derivatization of paclitaxel that has been
done in the last 10 years to enhance its solubility, permeability, and bioavailability. Different forms of
derivatization were done in order to improve the drug's ability to be absorbed by the body, as well as its
solubility and bioavailability.

Results:
This article explores the current and future strategies for increasing the anti-cancer efficacy of
paclitaxel by enhancing its bioavailability, solubility, and penetration efficacy. Some examples are lipidbased
delivery systems, polymer-based nanocarriers, crystal engineering (nanocrystals and co-crystals), liquidsolid
technologies, and self-emulsifying solid dispersions. Other strategies are also discussed in this article.

Conclusion:
It is quite likely that this review article will contain perfect fragments of evidence for building
a new model for the application of paclitaxel in the treatment of cancer.
An Ultrasound-assisted Three Component Protocol for the Regio and
Stereo-selective Synthesis of Some Novel Dispiroheterocycles and Their
Biological Evaluation as Anti-inflammatory, Anti-obesity Agents
Authors: Kumar Sanjeev , Saroha Bhavna , Lathwal Ekta , Kumar Gourav , Kumar Suresh , Kumar Ramesh , Arya Priyanka , Raghav Neera 
Published: March 2023

Background:
The increasing utilization of spiro compounds in drug discovery, led us to design
and synthesize regioselectively some novel dispiroheterocycles, by a standard 1,3-dipolar cycloaddition
reaction between 6-hydroxyaurone and in situ generated azomethine ylides, using ultra-sonication as
green energy source. These results are first of its kind in the literature reported so far for the similar conditions.
After confirmation of the proposed structures spectroscopically, using 1H NMR, 13C NMR and
FT-IR spectral data, all the compounds are screened for their potential biological activities.

Methods:
Three component protocol, that contain (Z)-2-benzylidene-6-hydroxybenzofuran-3(2H)-one,
sarcosine and unsubstituted isatin. In which azomethine ylides react with olefinic dipolarophiles through
1,3-dipolar cycloaddition, which is highly regio- and stero-selective way in situ. Structures of the proposed
products have been confirmed using 1H NMR, 13C NMR and FT-IR spectral data.

Results:
In order to screen the potential biological activities of the synthesized compounds, their effect
was observed on trypsin, amylase and lipase activities. Differential effect has been observed. Trypsin was
substantially activated whereas an inhibitory effect was observed for amylase and lipase supported by insilico
studies.

Conclusion:
Synthesis of six novel 6-hydroxy-1'-methyl-4'-phenyl-3H-dispiro[benzofuran-2,3'-
pyrrolidine-2',3''-indoline]-2'',3-dione derivatives have been made using a multicomponent greener protocol.
These synthesized compounds have exhibited differential effects toward trypsin, amylase and lipase
well supported by in-silico studies. Thus, the present study highlights their potential use as antiinflammatory
and anti-obesity agents.
Intravoxel Incoherent Motion Diffusion-weighted MRI Assessing the Effect of
the Vascular Disrupting Agent CA4P on VX2 Liver Tumors in Rabbits
Authors: Qian Ting , Yang Rong , Wang Yuzhe , Duan Qingqing 
Published: March 2023

Objective:
This study aimed to assess the response of combretastatin-A4-phosphate (CA4P) in rabbit VX2 liver tumors using intravoxel incoherent motion
diffusion-weighted MRI (IVIM DW-MRI).

Methods:
Forty rabbits with implanted VX2 liver tumors underwent baseline MRI and were then given 10 mg/kg CA4P (n=20) or saline (n=20). After 4 h,
10 rabbits from each group underwent an MRI examination and were then sacrificed. The remaining rabbits underwent MRI after 1, 3, and 7 days
and were then sacrificed. Liver samples were processed for H&E and immunohistochemical staining. IVIM parameters (D, f, D*) were compared
in the treatment and control groups, and the correlations of IVIM parameters with microvascular density (MVD) were determined.

Results:
At 4 h, the two treatment groups had significantly different f and D* values (p<0.001), and these values were at their minimum in the treatment
group. The treatment group had moderate correlations between MVD and f at 4 h (r=0.676, p=0.032) and 7 days (r=0.656, p=0.039) and with D* at
4 h (r=0.732, p=0.016) and 7 days (r=0.748, p=0.013), but no correlation was reported between MVD and f or D* in the control group (all P>0.05).

Conclusion:
IVIM DW-MRI is a sensitive imaging technique. It successfully evaluated the effect of CA4P on VX2 liver tumors in rabbits. The f and D* values
correlated with MVD at 4 h and 7 days after using CA4P, indicating that these parameters have the potential to be used as indicators of tumor
angiogenesis after treatment.
Identification of Signal of Clindamycin Associated Renal Failure Acute:
A Disproportionality Analysis
Authors: Javed Faiza , Kumar Anoop 
Published: March 2023

Background:
Early signal detection from post-marketing studies play a vital role in the
safety of patients. Recent case reports have indicated the association of clindamycin with renal
failure acute. However, renal failure acute is not known to be associated with clindamycin. The
aim of the study was the identification of the potential signal of clindamycin-associated renal failure
acute.

Methods:
The OpenVigil 2.1-MedDRA-v24 was used to query the FAERS database. The Reporting
Odds Ratio (ROR) with a 95% confidence interval, was used to assess the association between
clindamycin and renal failure acute.

Results:
A total of 22326 cases associated with renal failure acute were found in OpenVigil 2.1-
MedDRA-v24. Among these 125 were associated with clindamycin. The ROR was found to be 3.2
(2.7, 3.8) which indicates a statistically significant association between clindamycin and renal failure
acute reporting. The signal strength was decreased after removing the cases of concomitantly
administered drugs, however, the association of clindamycin with renal failure acute reporting remains
statistically significant. The subgroup analysis results have also shown a positive signal of
clindamycin with renal failure acute.

Conclusions:
The current study identified a positive signal of clindamycin as renal failure acute.
However, further validation and causality assessment are required.
Biochemical, Serological and Immunological Tests for Diagnosis of Coronavirus
Disease 2019 (COVID-19) Patients: A Comprehensive Systematic
Review and Meta-analysis
Authors: Azami Milad , Jamshidbeigi Amirreza , Ghaleh Hadi Esmaeili Gouvarchin , Ranjbar Reza 
Published: March 2023

Background:
Recent studies have suggested the role of primary laboratory tests in addition
to clinical symptoms for patients suspected to have coronavirus disease 2019 (COVID-19), which play
a significant role in the diagnosis of COVID-19. However, the results of these studies are contradictory.
The present study was conducted to evaluate biochemical, serological, and immunological tests for
the diagnosis of COVID-19 patients.

Methods:
This study was presented in accordance with the PRISMA protocol. This protocol is registered
with the code CRD42019145410 in PROSPERO. We conducted a comprehensive literature
search in databases, including Web of Science, PubMed/Medline, CINAHL Scopus, Cochrane Library,
EMBASE, Science Direct, and EBSCO to find citations from the beginning of January 2019 until the
beginning of April 2020 without any restrictions.

Results:
Finally, 51 studies, including 5,490 COVID-19 patients, were included in the present metaanalysis.
The prevalence of different factors observed in laboratory findings was as follows: the prevalence
of lymphopenia in patients with COVID-19 accounted for 51.6% (95% CI: 44.0-59.1), elevated
C-reactive protein (CRP) was 63.6% (95% CI: 57.0-69.8), elevated erythrocyte sedimentation rate
(ESR) was 62.5% (95% CI: 50.1-73.5), elevated tumor necrosis factor alpha (TNFα) was 28.7% (95%
CI: 9.0-62.1), elevated serum amyloid-A level was 74.7% (95% CI: 50.0-89.7), elevated procalcitonin
level was 72.6% (95% CI: 58.1-83.5), elevated interleukin-6 level was 59.9% (95% CI: 48.2-70.5),
reduced CD3 level was 68.3% (95% CI: 50.1-82.2), reduced CD4 level was 62.0% (95% CI: 51.1-
71.6), elevated lactate dehydrogenase (LDH) level accounted for 53.1% (95% CI: 43.6-62.4), elevated
brain natriuretic peptide (BNP) accounted for 48.9% (95% CI: 30.4-67.7), reduced albumin and reduced
pre-albumin levels in patients with COVID-19 were estimated to be 54.7% (95% CI: 38.1-70.2)
and 49.0% (95% CI: 26.6-71.8), and D-dimer level was 44.9% (95% CI: 31.0-59.6).

Conclusion:
The results show lymphopenia, elevated ESR level, elevated CRP level, elevated serum
amyloid-A, elevated TNFα, elevated procalcitonin level, elevated interleukin-6 level, reduced CD3,
reduced CD4, elevated BNP, elevated LDH, reduced albumin, reduced pre-albumin, and elevated Ddimer
levels as the most common findings at the time of admission.
An Analytic Review on Stock Market Price Prediction using Machine
Learning and Deep Learning Techniques
Authors: Rath Swarnalata , Das Nilima R. , Pattanayak Binod Kumar 
Published: March 2023

:
Anticipating stock market trends is a challenging endeavor that requires a lot of attention
because correctly predicting stock prices can lead to significant rewards if the right judgments are
made. Due to non-stationary, loud, and chaotic data, stock market prediction is challenging. Investors
need help to forecast where they should spend their money to make a profit. Investment methods
in the stock market are intricate and based on the analysis of large datasets. Expert analysts and
investors have placed a high value on developments in stock price prediction. Due to intrinsically
noisy settings and increased volatility concerning market trends, the stock market forecast for assessing
trends is tricky. The intricacies of stock prices are influenced by several elements, including
quarterly earnings releases, market news, and other altering habits. Traders use a number of
technical indicators based on stocks that are collected on a daily basis to make decisions. Even
though these indicators are used to analyze stock returns, predicting daily, and weekly market patterns
are difficult. Machine learning techniques have been extensively studied in recent years to see
if they might boost market predictions compared to legacy or conventional methods. The existing
methodologies have devised several strategies for predicting stock market trends. Various machine
learning and deep learning algorithms, such as SVM, DT, LR, NN, kNN, ANN, and CNN, can
boost performance in predicting the stock market. Based on a survey of current literature, this work
aims to identify future directions for machine learning stock market prediction research. This research
aims to provide a systematic literature review process to discover relevant peer-reviewed
journal papers from the last two decades and classify studies with similar methods and situations
into the machine learning approach and deep learning. In the current article, the methods and the
performance of those adopted methods will be identified for measuring the effectiveness of those
techniques.
KEDAULATAN DAN YURIDIKSI NEGARA DALAM PRESPEKTIF HUKUM INTERNASIONAL: SENGKETA PERAIRAN KEPULAUAN NATUNA
Authors: Joaquim Beli Quintao Emiliano Octo 
Published: March 2023

ABSTRACT

According to the Greek philosopher Aristotle, humans are social creatures (Zoon Politicon) which means society, that humans need each other, therefore law exists for public order. ? As in the writing of this scientific paper, it is aimed to find out the basis of international law for measuring the territorial borders of a country, in this case the dispute over the dispute over the Natuna territory in the South China Sea. Whereas in writing this scientific paper, normative juridical research methods are used, namely data collection techniques using reference books from competent legal experts and the basics of international law through International Organizational Instruments. From the legal facts found in the historical perspective and international law that the dispute in the waters of the Natuna Islands is a legitimate sovereign territory belonging to the Republic of Indonesia, the People's Republic of China only claims unilaterally without a valid international legal basis.
Severe delta variant COVID-19 in a 28-week infant with response to corticosteroids and remdesivir: a case report
Authors: King Adam , Hassell Jack , Gunathilaka Mastiyage Dona Gayani Nisansala , Storey Caroline , Graham-Evans Kate , Kachroo Rahul 
Published: March 2023

Background:
In the context of a global COVID-19 pandemic, there have been a variety of reports about the impact of infection to the fetus and in the immediate newborn period. Many babies appear to have a mild clinical course, but there is limited data about preterm infants.

Case Presentation:
A 28 week male infant was delivered with signs of fetal distress, four days after maternal infection with COVID-19. At this time, the delta variant of the virus predominated. After an initial period of stability, the baby significantly deteriorated in the second week and intensive care was escalated approaching maximal therapy. Given the life-threatening severity of the clinical condition, an off-licence trial of remdesivir was started alongside dexamethasone. With this treatment, the patient made a significant improvement and recovered.

Conclusion:
This case shows the feasibility of using remdesivir in the very premature neonatal population and seems to have been well tolerated.
Quelle place pour l’outil numérique dans l’enseignement de l’éducation physique et sportive ?
Authors: Dubuis Damien , Jungo Gaëtan , Tinguely Joachim , Hagin Vincent 
Published: March 2023

L’utilisation d’outils numériques en éducation physique et sportive (EPS), lorsque l’approche pédagogique est centrée sur les élèves, démontre des résultats positifs. Il est désormais reconnu que cette rétroaction vidéo permet le perfectionnement des habiletés motrices. Afin d’augmenter son efficacité, un feedback verbal de l’enseignant est attendu en complément. Le rôle de l’enseignant se trouve alors « augmenté » par l’apport de la technologie numérique. L’enseignement se voit amélioré et transformé. L’utilisation d’un modèle d’analyse, ici le SAMR afin de situer les étapes d’intégration de la technologie, s’avère nécessaire. Ainsi, élèves et enseignants ont la possibilité de suivre les mêmes étapes. En conclusion, l’apprentissage des élèves se trouve renforcé au travers de l’objectivation et de la représentation des tâches à perfectionner.
Quels sont les effets d’un jeu vidéo actif compétitif inter-équipes Play Lü sur l’intérêt en situation et l’activité physique des adolescents ?
Authors: Roure Cédric , Girod Guillaume , Lentillon-Kaestner Vanessa , Fargier Patrick 
Published: March 2023

Pour lutter contre l’inactivité physique des adolescents, des études ont montré que les jeux vidéo actifs (JVA) multi-joueurs proposant un affrontement entre deux équipes ont un impact (psychologique comme physiologique) supérieur à celui des JVA joués en solitaire. Cet impact a cependant été peu étudié dans le cas des JVA permettant un affrontement entre équipes durant la même session, en raison du faible nombre de dispositifs permettant ce mode de pratique. Le récent dispositif Play Lü® propose justement un mode multi-joueurs avec affrontement simultané de deux ou plusieurs équipes. Cette étude vise à rendre compte des effets d’une session Play Lü (15 min ; affrontement de deux équipes de trois joueurs) sur l’intérêt en situation et le degré d’activité physique de 128 adolescents (69 filles ; Mâge = 13.9±1.2 ans), en les comparant à ceux d’une session contrôle (sans Play Lü) utilisant les mêmes modalités de temps et d’équipes. Les résultats montrent que la session Play Lü a généré un intérêt en situation et une activité physique plus élevée.
Les défis coopétitifs : accessibilité et apprentissage
Authors: Bovas Magali , Moreira Marco 
Published: March 2023

Les capacités transversales du Plan d’études romand (PER) (collaboration, stratégies d’apprentissage, communication...) offrent un terrain d’application idéal pour penser l’hétérogénéité des élèves. Au cycle 1 a été développé un projet inspiré des défis « coopétitifs » (revue EPS) pour exercer la pensée créatrice dans une séquence jeu. Des cartes bonus/handicap permettent à l’équipe qui domine au score de choisir entre deux options : rendre la confrontation plus difficile ou permettre à l’autre équipe de bénéficier d’un avantage. La gestion des émotions suite à la victoire ou la défaite vécue à travers le corps constitue une piste intéressante pour développer des compétences psychosociales.
Les capacités transversales dans l’enseignement secondaire en éducation physique
Authors: Beetschen Jérémie 
Published: March 2023

Dans cet article, nous présentons le point de vue d’un enseignant du secondaire, Jérémie Beetschen, quant à l’implémentation des capacités transversales dans son enseignement en éducation physique.

Jérémie est enseignant spécialiste d’éducation physique à Genève. Il a principalement enseigné dans le secondaire I. Depuis sa titularisation il a également pu suivre un CAS portant sur la supervision et le suivi de stagiaires. A ce titre, il est aujourd’hui en mesure de témoigner de pratiques très diverses observées chez les stagiaires qu’il a pu accueillir. Fort d’un historique long dans son établissement, il a également eu l’occasion de collaborer avec de nombreux collègues aux expériences très variées (certains en début et d’autres en fin de carrière). Il nous partage donc non seulement son expérience personnelle d’enseignement des CT, mais également ses observations quant à la façon dont ses collègues et ses stagiaires les appréhendent.
Plan acción seguridad e higiene en centros de alojamiento de turistas en tiempo de post COVID-19
Authors: Cruz Baylon Claudia Janine , GONZALES JARA CAROLINA INES 
Published: March 2023

Los establecimientos de alojamiento de turistas hoy más que nunca deben de ofrecer orientaciones prácticas de vigilancia y protección durante la estancia debido a la inevitable interacción entre empleados y huéspedes en esta nueva normalidad. El propósito del estudio fue proponer un Plan acción centrado en la seguridad e higiene en centros de alojamiento de turistas en tiempos de post COVID-19. El estudio se configuró dentro del enfoque cuantitativo, de tipo descriptivo proyectivo, contando con una muestra intencional de 53 personas que laboran en el alojamiento. El instrumento implementado fue PRESEHI-21 creado por la investigadora, con una escala de likert de 25 ítems, se validó mediante el juicio de expertos y una confiabilidad alta. Los resultados evidenciaron una baja y moderada seguridad e higiene para prevenir los riesgos de contagio del virus COVID-19. Demostrando la necesidad de una guía o plan que facilite el cumplimiento de normas de seguridad e higiene en el centro de alojamiento. Concluyendo que el Plan acción centrado en la seguridad e higiene en centros de alojamiento de turistas es una herramienta cuyas acciones permiten mejorar y controlar los procesos en función al resguardo, cuidado de la salud de quienes se encuentran laborando y disfrutando de las instalaciones.
INCENTIVOS TRIBUTARIOS DE EMPRESAS TURÍSTICAS Y HOTELERAS DE LA PROVINCIA DE TUNGURAHUA, BAJO TEORÍA DEL REFORZAMIENTO DE FREDERIC SKINNER, PERIODO 2019-2020
Authors: CHANGO MARIELA , Benavides- Echeverría Iralda Benavides- Echeverría , Panchi-Pastora Viviana Panchi-Pastora 
Published: March 2023

En la última década el Turismo representa un impacto en la sociedad Moderna, en tal virtud los incentivos tributarios en las actividades desarrolladas por las empresas Turísticas y Hoteleras de la provincia de Tungurahua permitira evidenciar lo afirmado. El enfoque de la investigación es mixto, el tipo de investigación es descriptiva y explicativa, el diseño es no experimental y la modalidad es una investigación de campo, se aplicó un instrumento de 353 encuestas dirigidas a los contribuyentes que integran los cinco sectores de las actividades turísticas de la provincia de Tungurahua conformado por los cantones de Ambato, Baños, Pelileo, Mocha, Patate, Quero, Cevallos, Tisaleo y Pillaro. Entre las conclusiones, está fortalecer la difusión y aplicación de los incentivos tributarios, con el objetivo de impulsar el desarrollo y crecimiento económico. Entre los resultados El 54% manifesta que conoce la existencia de estos beneficios tributarios directos con el sector, pero por el desconocimiento de aplicabilidad no se practica en algunos casos por parte de los empresarios y/o contadores; respecto al aporte de los incentivos al sector, el 35% considera que los beneficios tributarios apoyan a la generación de más fuentes de empleo.
Palabras Clave: Empresas turísticas, Hotelería y turismo, Tributación – Impuestos.
Evaluation of the Regression Coefficient between the Activity of FoxP3 Gene on Regulatory T Cells and Glucose Level in Patients with type 1 Diabetes Mellitus In the City of Mosul
Authors: Ali Saad Imrrer , AL-Allaff Rojan G.M. 
Published: March 2023

Still, external insulin therapy with its various types causes a variety of immune reactions through its variable control of the glucose level in patients with type 1 diabetes. However, major immune problems are uncommon, and less serious diabetic events have long-term effects on immune responses. The current study aimed to follow up the effect of glucose levels on the level of gene expression of the FoxP3 gene, one of the most important genes responsible for the activity of Regulatory T cells in patients with type 1 diabetes. (26) blood samples were collected from individuals diagnosed with type 1 diabetes for a period of more than (5) years, their ages ranged from (15-35) years, and from both sexes, from Al-Wafa Center for the treatment of diabetics and endocrine glands in the city of Mosul. The patients were divided into four groups, depending on the type of insulin injection , These groups included (Actrapid patients group, Insulatard patients group, Insulatard / Actrapid patients patients group, and finally Mixtard patients group). The control group also included (7) blood samples of healthy people as donors, ages ranging from (15-30) years, (males and females), without communicable diseases, bacterial infections, or autoimmune diseases. . The results showed an effect of glucose concentration on the expression level of the FoxP3 gene by (26%) in the group of patients who used insulin mixtard type, while the results of the effect analysis of glucose on the level of gene expression of the FoxP3 gene showed a rate of (76%) in the group of patients who used insulin type Insulatard, On the contrary, there was no effect of glucose concentration on the level of FoxP3 gene expression in patients using Actrapid and Insulatard / Actrapid insulin at (P≤0.05).