bluuebunny/crossref_metadata_2025_split huggingface dataset:
Incorporating Tantalum Oxide Nanoparticles into Implantable Polymeric Biomedical Devices for Radiological Monitoring
Authors: Pawelec Kendell M. , Tu Ethan , Chakravarty Shatadru , Hix Jeremy M. L. , Buchanan Lane , Kenney Legend , Buchanan Foster , Chatterjee Nandini , Das Subhashri , Alessio Adam , Shapiro Erik M. 
Published: February 2023

AbstractLongitudinal radiological monitoring of biomedical devices is increasingly important, driven by the risk of device failure following implantation. Polymeric devices are poorly visualized with clinical imaging, hampering efforts to use diagnostic imaging to predict failure and enable intervention. Introducing nanoparticle contrast agents into polymers is a potential method for creating radiopaque materials that can be monitored via computed tomography. However, the properties of composites may be altered with nanoparticle addition, jeopardizing device functionality. Thus, the material and biomechanical responses of model nanoparticle‐doped biomedical devices (phantoms), created from 0–40 wt% tantalum oxide (TaOx) nanoparticles in polycaprolactone and poly(lactide‐co‐glycolide) 85:15 and 50:50, representing non, slow, and fast degrading systems, respectively, are investigated. Phantoms degrade over 20 weeks in vitro in simulated physiological environments: healthy tissue (pH 7.4), inflammation (pH 6.5), and lysosomal conditions (pH 5.5), while radiopacity, structural stability, mechanical strength, and mass loss are monitored. The polymer matrix determines overall degradation kinetics, which increases with lower pH and higher TaOxcontent. Importantly, all radiopaque phantoms could be monitored for a full 20 weeks. Phantoms implanted in vivo and serially imaged demonstrate similar results. An optimal range of 5–20 wt% TaOxnanoparticles balances radiopacity requirements with implant properties, facilitating next‐generation biomedical devices.
Influence of Pore Size in Protein G'‐Grafted Mesoporous Silica Nanoparticles as a Serum Pretreatment System for In Vitro Allergy Diagnosis
Authors: Paris Juan L. , Monío Cristina , Pérez‐Moreno Ana M. , Jurado‐Escobar Raquel , Bogas Gador , Fernández Tahía D. , Montañez María I. , Mayorga Cristobalina , Torres María J. 
Published: February 2023

AbstractParticles with the capacity to bind to immunoglobulin G (IgG) can be used for the purification of IgG or to process clinical samples for diagnostic purposes. For in vitro allergy diagnosis, the high IgG levels in serum can interfere with the detection of allergen‐specific IgE, the main diagnostic biomarker. Although commercially available, current materials present a low IgG capture capacity at large IgG concentrations or require complex protocols, preventing their use in the clinic. In this work, mesoporous silica nanoparticles are prepared with different pore sizes, to which IgG‐binding protein G’ is grafted. It is found that for one particular optimal pore size, the IgG capture capacity of the material is greatly enhanced. The capacity of this material to efficiently capture human IgG in a selective way (compared to IgE) is demonstrated in both solutions of known IgG concentrations as well as in complex samples, like serum, from healthy controls and allergic patients using a simple and fast incubation protocol. Interestingly, IgG removal using the best‐performing material enhances in vitro IgE detection in sera from patients allergic to amoxicillin. These results highlight the great translation potential of this strategy to the clinic in the context of in vitro allergy diagnosis.
Coupled Tamm Phonon and Plasmon Polaritons for Designer Planar Multiresonance Absorbers
Authors: He Mingze , Nolen Joshua Ryan , Nordlander Josh , Cleri Angela , Lu Guanyu , Arnaud Thiago , McIlwaine Nathaniel S. , Diaz‐Granados Katja , Janzen Eli , Folland Thomas G. , Edgar James H. , Maria Jon‐Paul , Caldwell Joshua D. 
Published: February 2023

AbstractWavelength‐selective absorbers (WS‐absorbers) are of interest for various applications, including chemical sensing and light sources. Lithography‐free fabrication of WS‐absorbers can be realized via Tamm plasmon polaritons (TPPs) supported by distributed Bragg reflectors (DBRs) on plasmonic materials. While multifrequency and nearly arbitrary spectra can be realized with TPPs via inverse design algorithms, demanding and thick DBRs are required for high quality‐factors (Q‐factors) and/or multiband TPP‐absorbers, increasing the cost and reducing fabrication error tolerance. Here, high Q‐factor multiband absorption with limited DBR layers (3 layers) is experimentally demonstrated by Tamm hybrid polaritons (THPs) formed by coupling TPPs and Tamm phonon polaritons when modal frequencies are overlapped. Compared to the TPP component, the Q‐factors of THPs are improved twofold, and the angular broadening is also reduced twofold, facilitating applications where narrow‐band and nondispersive WS‐absorbers are needed. Moreover, an open‐source algorithm is developed to inversely design THP‐absorbers consisting of anisotropic media and exemplify that the modal frequencies can be assigned to desirable positions. Furthermore, it is demonstrated that inversely designed THP‐absorbers can realize same spectral resonances with fewer DBR layers than a TPP‐absorber, thus reducing the fabrication complexity and enabling more cost‐effective, lithography‐free, wafer‐scale WS‐absorberss for applications such as free‐space communications and gas sensing.
Specific and Long‐Term Luminescent Monitoring of Hydrogen Peroxide in Tumor Metastasis
Authors: Wang Xindong , Fu Ji , Jiang Chang , Liao Xiaohui , Chen Yiju , Jia Tao , Chen Guanying , Feng Xue 
Published: February 2023

AbstractLuminescent monitoring of endogenous hydrogen peroxide (H2O2) in tumors is conducive to understanding metastasis and developing novel therapeutics. The clinical transformation is obstructed by the limited light penetration depth, toxicity of nano‐probes, and lack of long‐term monitoring modes of up to days or months. New monitoring modes are introduced via specific probes and implantable devices, which can achieve real‐time monitoring with a readout frequency of 0.01 s or long‐term monitoring for months to years. Near‐infrared dye‐sensitized upconversion nanoparticles (UCNPs) are fabricated as the luminescent probes, and the specificity to reactive oxygen species is subtly regulated by the self‐assembled monolayers on the surfaces of UCNPs. Combined with the passive implanted system, a 20‐day monitoring of H2O2 in the rat model of ovarian cancer with peritoneal metastasis is achieved, in which the limited light penetration depth and toxicity of nano‐probes are circumvented. The developed monitoring modes show great potential in accelerating the clinical transformation of nano‐probes and biochemical detection methods.
Walking Ferroelectric Liquid Droplets with Light
Authors: Marni Stefano , Nava Giovanni , Barboza Raouf , Bellini Tommaso Giovanni , Lucchetti Liana 
Published: February 2023

AbstractThe motion of ferroelectric liquid sessile droplets deposited on a ferroelectric lithium niobate substrate can be controlled by a light beam of moderate intensity irradiating the substrate at a distance of several droplet diameters from the droplet itself. The ferroelectric liquid is a nematic liquid crystal, in which almost complete polar ordering of the molecular dipoles generates an internal macroscopic polarization locally collinear to the mean molecular long axis. Upon entering the ferroelectric phase, droplets are either attracted toward the center of the beam or repelled, depending on the side of the lithium niobate exposed to light irradiation. Moreover, moving the beam results in walking the ferroelectric droplet over long distances on the substrate. This behavior is understood as due to the coupling between the polarization of the ferroelectric droplet and the polarization photoinduced in the irradiated region of the lithium niobate substrate. Indeed, the effect is not observed in the conventional nematic phase, suggesting the crucial role of the ferroelectric liquid crystal polarization.
Atomically Thin Twisted Heterostructure Optoelectronics Enhanced via vdW Interface Engineering
Authors: Li Ling , Fu Xiang , Zhang Liang , Ullah Salman , Gao Xingjun , Wang Yixiu , Wu Wenzhuo , Xiang Yuan , Yang Qing 
Published: February 2023

AbstractTwo‐dimensional (2D) heterostructures have sparked widespread interest in physics and device applications. The interfacial band alignment engineering of 2D heterostructures opens promising routes for high‐performance electronics and optoelectronics. In this study, a 2D Te/MoS2 interface is engineered by tailoring the lattice mismatch and distance, which changed the band alignment. The photocurrent is significantly increased by optimizing the interface alignment. The corresponding device is designed to function as an ultrasensitive photodetector with a light on/off ratio of 104, responsivity of ≈1047 A W−1, and detectivity of >5 × 1012 Jones, as well as a spectral detection capability of up to 1550 nm. The proposed methods are robust and versatile and can be used to produce desired electronics; hence, this study may broaden the scope of 2D heterostructure optoelectronics.
A Long‐Range and Nearly Passive RFID‐Controlled Information Metasurface
Authors: Wang Zheng Xing , Shen Chuan Kui , Wu Jun Wei , Xu Hui , Cheng Qiang , Ye Terry Tao , Cui Tie Jun 
Published: February 2023

AbstractInformation metasurfaces (IMSs) have been considered to be a revolutionary technology for improving the spectral efficiency of sixth‐generation (6G) wireless communications due to their superior ability to manipulate electromagnetic (EM) waves. However, there are still problems to be solved before the widespread application of IMSs. The first is to reduce power consumption, and the second is to achieve a long‐range remote control. In this paper, a long‐range and nearly passive radio frequency identification (RFID)‐controlled IMS is proposed. The proposed IMS comprises four RFID tags and 8 × 8 elements, each of which is integrated with a single‐pole‐double‐throw switch chip to achieve 1‐bit phase reconfigurability. With the remote control of the RFID system, the IMS can be programmed to switch between three functionalities, including beam splitting, beamforming, and EM‐wave absorption. Experiments are performed and the beam‐splitting functionality is demonstrated. The measurement results indicate that the wireless communication between the RFID reader and the IMS is robust within 21.7 m. Additionally, the power consumption of the IMS is as low as 0.576 mW, which can be negligible. The scheme presented in this paper paves the way for the large‐scale applications of IMSs in 6G wireless communications.
Multiple Charge Transfer Processes Enable Blue Emitter for Highly Efficient OLEDs
Authors: Wang Zhichuan , Li Deli , Li Wei , Zhang Jiasen , Luo Ming , Du Songyu , Zhang Xiaoli , Xu Shengang , Ge Ziyi 
Published: February 2023

AbstractSolely through‐space charge transfer (TSCT)‐type thermally activated delayed fluorescent (TADF) emitters exhibit low radiative decay rates (), while solely through‐bond charge transfer (TBCT) type TADF emitters generally suffer from low reverse intersystem crossing (RISC) rates (kRISC). Here, PhCzSpiroS‐TRZ with versatile spiro‐heterocyclic architecture and an extra donor of 9‐phenyl‐9H‐carbazole are developed as emitter and ideal host for TADF‐ and TADF‐sensitized fluorescence (TSF) organic light‐emitting diodes (OLEDs) in detail. Abandoning solely TSCT or TBCT process, PhCzSpiroS‐TRZ with multiple charge transfer characteristic exhibits photoluminescence quantum yield of 96.3% and of 2.2 × 107 s−1, which is considerably higher among all the reported TSCT‐TADF molecules. Noticeably, state‐of‐the‐art blue OLEDs using PhCzSpiroS‐TRZ as emitter and sensitizer show maximum external quantum efficiencies (EQEs) of 33.6% and 32.8%, ranking among TADF materials for achieving EQEs >30% in both TADF‐ and TSF‐OLEDs.
Recent Advances in Wearable Tactile Sensors Based on Electrospun Nanofiber Platform
Authors: Wang Peng , Liu Jun , Li Yurui , Li Guoxian , Yu Wei , Zhang Yanxi , Meng Chuizhou , Guo Shijie 
Published: February 2023

AbstractWearable electronics have triggered the great development of flexible tactile sensors for promising applications such as healthcare monitoring, motion detection, and human‐machine interaction. However, most of the flexible sensors are constructed on compact and airtight polymer films with inferior flexibility and no breathability, hindering the wearability and comfortability for long‐time continuous operation usage. To address such challenges, flexible sensors based on the electrospun polymer platform with comprehensive advantages of ultrathin thickness, superior flexibility, excellent stretchability, high porosity, low density, and surface functionality are emerging. It has become a hot research direction, and considerable progress has been made. Therefore, it is necessary to timely review the latest findings on the rapidly developing electrospun nanofiber‐based tactile sensors. Firstly, the principle of the electrospinning technique, the factors affecting the nanofiber morphology, and the engineering of the nanofibers are briefly introduced, and the key material and structural factors affecting the sensing performance are analyzed. Secondly, representative work on the electrospun nanofiber‐based tactile sensors is discussed in detail according to the sensing mechanism. Thirdly, unique properties of electrospun nanofibers, such as superior flexibility, breathability, hydrophobicity, anti‐bacterial, and self‐cleaning, are highlighted. Finally, the remaining challenges and future development trends are outlined.
Advanced Bioinspired Organic Sensors for Future‐Oriented Intelligent Applications
Authors: Lu Kuakua , Li Longfei , Jiang Sai , Chen Xu , Chang Qiong , Shi Yi , Li Yun 
Published: February 2023

AbstractBioinspired organic sensors with excellent flexibility, biocompatibility, sensing performance, and self‐adaptability have attracted considerable attention due to their fundamental role in next‐generation intelligent sensory systems with simultaneous sensing and processing functions, such as advanced robots, disease diagnosis, Internet of Things, human–robot interaction systems, and beyond. The design of advanced bioinspired organic sensors requires a deep understanding of the interplay between the unique material property, sensing mechanism as well as intelligent functionality. Here, the recent progress of bioinspired organic sensors for artificial perceptron covering visual, tactile, and other bionic sensors from the view of materials, sensing mechanisms, and functionality, is summarized. Furthermore, the intelligent applications of bioinspired organic sensors, including associative learning, information security, electronic skin, and integrated artificial sensory systems, are presented. Finally, the potential challenges and prospects of bioinspired organic sensors are discussed, providing a promising avenue toward advanced bioinspired organic sensors for future‐oriented intelligent applications.
A novel de novo pathogenic variant in TBL1XR1 as a new proposed cause of Pierpont syndrome
Authors: Tamma Poornima L. , Streff Haley , Murali Chaya N. 
Published: February 2023

AbstractTBL1XR1, which encodes transducing β‐like 1 X‐linked receptor 1, is implicated in both Pierpont syndrome and intellectual developmental disorder, autosomal dominant‐41 (MRD‐41, OMIM #616944). While both conditions are autosomal dominant, variants associated with Pierpont syndrome are believed to behave in a dominant negative fashion, whereas those causing MRD‐41 result in haploinsufficiency. Here, we present a patient with a de novo novel variant in TBL1XR1 (c.977G > A,p.S326N) identified by trio exome sequencing. Though a different variant at this same residue has previously been associated with MRD‐41, our patient's presentation is suggestive of Pierpont syndrome. The patient's clinical phenotype, which includes short stature, developmental delay, dysmorphic craniofacial features, and plantar fat pads, more closely resembles that of known patients with Pierpont syndrome than MRD‐41. Furthermore, this missense variant is directly adjacent to one previously associated with Pierpont syndrome and exists in the same region as all variants associated with Pierpont, on the inner surface of a WD40 ring. We propose this variant is a newly identified cause of Pierpont syndrome.
Prenatal household size and composition are associated with infant fecal bacterial diversity in Cebu, Philippines
Authors: Manus Melissa B. , Watson Elijah , Kuthyar Sahana , Carba Delia , Belarmino Nikola M. , McDade Thomas W. , Kuzawa Christopher W. , Amato Katherine R. 
Published: February 2023

AbstractObjectivesThe gut microbiome (GM) connects physical and social environments to infant health. Since the infant GM affects immune system development, there is interest in understanding how infants acquire microbes from mothers and other household members.Materials and MethodsAs a part of the Cebu Longitudinal Health and Nutrition Survey (CLHNS), we paired fecal samples (proxy for the GM) collected from infants living in Metro Cebu, Philippines at 2 weeks (N = 39) and 6 months (N = 36) with maternal interviews about prenatal household composition. We hypothesized that relationships between prenatal household size and composition and infant GM bacterial diversity (as measured in fecal samples) would vary by infant age, as well as by household member age and sex. We also hypothesized that infant GM bacterial abundances would differ by prenatal household size and composition.ResultsData from 16 S rRNA bacterial gene sequencing show that prenatal household size was the most precise estimator of infant GM bacterial diversity, and that the direction of the association between this variable and infant GM bacterial diversity changed between the two time points. The abundances of bacterial families in the infant GM varied by prenatal household variables.ConclusionsResults highlight the contributions of various household sources to the bacterial diversity of the infant GM, and suggest that prenatal household size is a useful measure for estimating infant GM bacterial diversity in this cohort. Future research should measure the effect of specific sources of household bacterial exposures, including social interactions with caregivers, on the infant GM.
Change in Cerebrospinal Fluid Tau Microtubule Binding Region Detects Symptom Onset, Cognitive Decline, Tangles, and Atrophy in Dominantly Inherited Alzheimer's Disease
Authors: Horie Kanta , Li Yan , Barthélemy Nicolas R. , Gordon Brian , Hassenstab Jason , Benzinger Tammie L.S. , Fagan Anne M. , Morris John C. , Karch Celeste M. , Xiong Chengjie , Allegri Ricardo , Mendez Patricio Chrem , Ikeuchi Takeshi , Kasuga Kensaku , Noble James , Farlow Martin , Chhatwal Jasmeer , Day Gregory , Schofield Peter R. , Masters Colin L. , Levin Johannes , Jucker Mathias , Lee Jae‐Hong , Roh Jee Hoon , Sato Chihiro , Sachdev Pallavi , Koyama Akihiko , Reyderman Larisa , Bateman Randall J. , McDade Eric ,   and the Dominantly Inherited Alzheimer Network
Published: February 2023

ObjectiveIdentifying cerebrospinal fluid measures of the microtubule binding region of tau (MTBR‐tau) species that reflect tau aggregation could provide fluid biomarkers that track Alzheimer's disease related neurofibrillary tau pathological changes. We examined the cerebrospinal fluid (CSF) MTBR‐tau species in dominantly inherited Alzheimer's disease (DIAD) mutation carriers to assess the association with Alzheimer's disease (AD) biomarkers and clinical symptoms.MethodsCross‐sectional and longitudinal CSF from 229 DIAD mutation carriers and 130 mutation non‐carriers had sequential characterization of N‐terminal/mid‐domain phosphorylated tau (p‐tau) followed by MTBR‐tau species and tau positron emission tomography (tau PET), other soluble tau and amyloid biomarkers, comprehensive clinical and cognitive assessments, and brain magnetic resonance imaging of atrophy.ResultsCSF MTBR‐tau species located within the putative “border” region and one species corresponding to the “core” region of aggregates in neurofibrillary tangles (NFTs) increased during the presymptomatic stage and decreased during the symptomatic stage. The “border” MTBR‐tau species were associated with amyloid pathology and CSF p‐tau; whereas the “core” MTBR‐tau species were associated stronger with tau PET and CSF measures of neurodegeneration. The ratio of the border to the core species provided a continuous measure of increasing amounts that tracked clinical progression and NFTs.InterpretationChanges in CSF soluble MTBR‐tau species preceded the onset of dementia, tau tangle increase, and atrophy in DIAD. The ratio of 4R‐specific MTBR‐tau (border) to the NFT (core) MTBR‐tau species corresponds to the pathology of NFTs in DIAD and change with disease progression. The dynamics between different MTBR‐tau species in the CSF may serve as a marker of tau‐related disease progression and target engagement of anti‐tau therapeutics. ANN NEUROL 2023;93:1158–1172
Biological Age Acceleration and Motoric Cognitive Risk Syndrome
Authors: Sathyan Sanish , Ayers Emmeline , Adhikari Dristi , Gao Tina , Milman Sofiya , Barzilai Nir , Verghese Joe 
Published: February 2023

ObjectiveMotoric cognitive risk (MCR) syndrome, a predementia syndrome characterized by slow gait and subjective cognitive concerns, is associated with multiple age‐related risk factors. We hypothesized that MCR is associated with biological age acceleration. We examined the associations of biological age acceleration with MCR, and mortality risk in MCR cases.MethodsBiological age was determined using proteomic and epigenetic clocks in participants aged 65 years and older in the LonGenity study (N = 700, females = 57.9%) and Health and Retirement Study (HRS; N = 1,043, females = 57.1%) cohorts. Age acceleration (AgeAccel) was operationally defined as the residual from regressing predicted biological age (from both clocks separately) on chronological age. Association of AgeAccel with incident MCR in the overall sample as well as with mortality risk in MCR cases was examined using Cox models and reported as hazard ratios (HRs).ResultsAgeAccel scores derived from a proteomic clock were associated with prevalent MCR (odds ratio adjusted for age, gender, education years, and chronic illnesses [aOR] = 1.36, 95% confidence interval [CI] = 1.09–1.71) as well as predicted incident MCR (HR = 1.19, 95% CI = 1.00–1.41) in the LonGenity cohort. In HRS, the association of AgeAccel using an epigenetic clock with prevalent MCR was confirmed (aOR = 1.47, 95% CI = 1.16–1.85). Participants with MCR and accelerated aging (positive AgeAccel score) were at the highest risk for mortality in both LonGenity (HR = 3.38, 95% CI = 2.01–5.69) and HRS (HR = 2.47, 95% CI = 1.20–5.10).InterpretationAccelerated aging predicts risk for MCR, and is associated with higher mortality in MCR patients. ANN NEUROL 2023;93:1187–1197