bluuebunny/crossref_metadata_2025_split huggingface dataset:
Trust, power, and organizational routines: Exploring government's intentional tactics to renew relationships with nonprofits serving historically marginalized communities
Authors: Cheng Yuan (Daniel) , Sandfort Jodi 
Published: December 2022

AbstractExisting public management practices and organizational routines in the contracting regime have systematically created power asymmetry and distrust between government agencies and nonprofits serving historically marginalized communities. However, little is known about how the government could reform public bureaucracies to renew relationships with these important organizations and build trust. Through a process‐oriented inductive study of Minnesota's 2‐Generation Policy Network, we find that government's cascading trust‐building tactics both inside the bureaucracy and with nonprofits serving Black, Latino, Indigenous, and Immigrant/Refugee communities allowed them to create a new collaborative infrastructure that both changed organizational routines and built power to address racial inequities in the existing human service system. Power is not a zero‐sum game. By sharing resources and building trust with their nonprofit partners, government agencies and nonprofits collectively access more power for genuine public management reform to address systematic inequities.
Evaluating the impact of different spatial linkages on forum outcome interdependencies in polycentric systems
Authors: McLaughlin Danielle M. 
Published: December 2022

AbstractIn complex polycentric systems, decisions regarding the governance of certain subsystems (e.g., watersheds) are often determined by networks of diverse actors who participate across a range of forums tackling interconnected collective actions issues (e.g., water quality, biodiversity, flood management). Compounding this structural complexity are the multifaceted interdependencies that exist between forums across a system. Drawing on the Ecology of Games Theory (EGT), this article investigates the impact of different types of network linkages on outcome interdependence between forums. Using a series of spatial autoregressive models on data collected in a Tampa Bay water governance system, I find evidence that co‐membership and organizational networks serve as pathways for outcome spillovers between forums. Building theory that helps elucidate how different types of network relationships may influence outcomes across a system is critical for the continued development of EGT and the governance of polycentric systems.
Justice in Black and Brown: The impact of political control and representative bureaucracy on street level outcomes
Authors: Jackson William T. , Neshkova Milena I. , Meier Kenneth J. 
Published: December 2022

AbstractThis study tests the explanatory power of two prominent public administration theories—political control and representative bureaucracy—in understanding disparities in public service provision. While prior research focused on street‐level bureaucracy, we study here how political and group identities of top elected law enforcement officials affect the distribution of youth arrests, alternatives, and prosecutions among minority groups. Data from Florida's 67 counties between 2015 and 2020 demonstrate that sheriff's and state attorney's party affiliation, race, and ethnicity do affect street‐level outcomes. However, the effects are more pronounced for race than ideology. Also, representative bureaucracy appears more relevant for race than ethnicity and explains the behavior of Black sheriffs but not Black state attorneys.
School Book Publishing
Authors: Seshadri Sesh 
Published: December 2022

Abstract
Educational publishing in India has contributed to the growth of human development. There is still much room for bringing in new thought processes and best practices. In this context, a few models that were followed in the past can be brought back for the good of the industry. These models all worked, and it is up to the industry to revisit and reform them. The dropout rate in schools is coming down and the number of schools will continue to grow. And that is great news.
Roli Books
Authors: Kapoor Pramod 
Published: December 2022

Abstract
Roli Books was set up in 1978 and tasted early success by bringing affordable, full-colour primary school textbooks to India. But the founder, Pramod Kapoor, followed through on his dream of creating indigenous, high-quality illustrated books for India, convinced that combining the content and editorial skills available in the country with international quality printing would be a winning proposition. Roli kept scaling up and expanded to multiple overseas markets while dealing with Indian policy challenges such as restrictions on third-country exports and the cap on book imports. After a challenging period in the late eighties and early nineties, Roli found success once again, buoyed by India’s economic liberalisation and the lifting of import restrictions. Since the late 2000s, Roli has invested in its domestic publishing programme, physical retail space, and annual exhibitions to build the brand. The next generation of the family continues to nurture and grow the company.
Sarat Book House
Authors: De Milinda 
Published: December 2022

Abstract
The journey of Sarat Book House, set up close to 70 years ago in Kolkata, documents the evolution and growth of a regional bookseller and publisher in India, and how it has adapted to the changing demands of the bookselling and publishing ecosystem. From early innovations such as opening shelves for customers to browse and curating a niche and rare list of specialist titles, the second generation of the family feels equally dedicated to the books business and has ushered in the next level of changes such as computerisation, starting Sarat’s own publishing and reprints lists, expanding to other parts of the country, and running its own press. Subject to systemic and evolutionary challenges, the publishing and bookselling ecosystem demands an agile, flexible yet long-term approach from players like Sarat Book House.
PhenoExam: gene set analyses through integration of different phenotype databases
Authors: Cisterna Alejandro , González-Vidal Aurora , Ruiz Daniel , Ortiz Jordi , Gómez-Pascual Alicia , Chen Zhongbo , Nalls Mike , Faghri Faraz , Hardy John , Díez Irene , Maietta Paolo , Álvarez Sara , Ryten Mina , Botía Juan A. 
Published: December 2022

Abstract
Background
Gene set enrichment analysis (detecting phenotypic terms that emerge as significant in a set of genes) plays an important role in bioinformatics focused on diseases of genetic basis. To facilitate phenotype-oriented gene set analysis, we developed PhenoExam, a freely available R package for tool developers and a web interface for users, which performs: (1) phenotype and disease enrichment analysis on a gene set; (2) measures statistically significant phenotype similarities between gene sets and (3) detects significant differential phenotypes or disease terms across different databases.

Results
PhenoExam generates sensitive and accurate phenotype enrichment analyses. It is also effective in segregating gene sets or Mendelian diseases with very similar phenotypes. We tested the tool with two similar diseases (Parkinson and dystonia), to show phenotype-level similarities but also potentially interesting differences. Moreover, we used PhenoExam to validate computationally predicted new genes potentially associated with epilepsy.

Conclusions
We developed PhenoExam, a freely available R package and Web application, which performs phenotype enrichment and disease enrichment analysis on gene set G, measures statistically significant phenotype similarities between pairs of gene sets G and G′ and detects statistically significant exclusive phenotypes or disease terms, across different databases. We proved with simulations and real cases that it is useful to distinguish between gene sets or diseases with very similar phenotypes.
Github R package URL is https://github.com/alexcis95/PhenoExam.
Shiny App URL is https://alejandrocisterna.shinyapps.io/phenoexamweb/.
Association between basal septal hypertrophy and left ventricular geometry in a community population
Authors: Gao Lan , Ma Wei , Li Min , Yang Ying , Qi Litong , Zhang Baowei , Wang Chonghui , Zhang Yan , Huo Yong 
Published: December 2022

Abstract
Background
Left ventricular (LV) geometry is closely associated with cardiovascular disease; however, few studies have evaluated the relationship between basal septal hypertrophy (BSH) and LV geometry. In this study, we examined the relationship between BSH and LV geometry in a Beijing community population.

Methods
The clinical and echocardiographic data of 1032 participants from a community in Beijing were analyzed. BSH was defined as a basal interventricular septal thickness ≥ 14 mm and a basal septal thickness/mid-septal thickness ≥ 1.3. On the basis of their echocardiographic characteristics, patients were described as having a normal geometry, concentric remodeling, concentric hypertrophy, or eccentric hypertrophy. Multivariable logistic regression was used to analyze the relationship between BSH, LV mass index (LVMI), and relative wall thickness (RWT).

Results
The prevalence of BSH was 7.4% (95% confidence interval [CI] 5.8–9.0%). Basal and middle interventricular septal thickness, LV posterior wall thickness, and RWT were greater, while LVMI and LV end-diastolic dimension were lower in the BSH group than in the non-BSH group (p < 0.05). The BSH group accounted for the highest proportion of patients with concentric remodeling. A multivariable regression analysis showed that BSH increased by 3.99-times (odds ratio [OR] 3.99, 95% CI 2.05–7.78, p < 0.01) when RWT was > 0.42, but not when LVMI increased (OR 0.16, 95% CI 0.02–1.19, p = 0.07). There were no interactions between BSH and age, body mass index, sex, diabetes mellitus, coronary heart disease, stroke, and smoking in relation to an RWT > 0.42.

Conclusion
BSH was independently associated with an RWT > 0.42.
Reserve and resilience in CKD: concept introduction and baseline results from the Physical REsilience Prediction in Advanced REnal Disease (PREPARED) study
Authors: Bowling C. Barrett , Olsen Maren K. , Berkowitz Theodore S. Z. , Smith Battista , Floyd Breana , Majette Nadya , Miles Amy L. , Crowley Steven D. , Wang Virginia , Maciejewski Matthew L. , Whitson Heather E. 
Published: December 2022

Abstract
Background
The purpose of this manuscript is to introduce reserve and resilience as novel concepts in chronic kidney disease (CKD) research and present baseline data from a unique prospective cohort study designed to characterize recovery from functional decline after a health event.

Methods
The Physical REsilience Prediction in Advanced REnal Disease (PREPARED) study recruited a national, prospective cohort of Veterans ≥70 years old with an estimated glomerular filtration rate (eGFR) < 30 ml/min/1.73 m2, prior nephrology care, and at high risk for hospitalization. Electronic health record data were paired with telephone surveys. Self-reported measures of reserve included physical, psychological, and cognitive capacity and environmental resources. We calculated counts (frequencies) and medians (25th, 75th percentiles) for baseline measures of reserve. The study’s longitudinal follow-up of physical function every 8 weeks or following an acute care encounter, which will be used to define resilience, is ongoing.

Results
Participants had a median (25th, 75th percentile) age of 76.3 (72.8, 81.4) years and eGFR of 23.4 (18.2, 28.8) ml/min/1.73 m2; 23.3% were Black, and 97.4% were male, 91.6% had hypertension, 67.4% had diabetes mellitus, 46.0% had coronary heart disease, and 39.8% had heart failure. Baseline measures of physical, psychological, and cognitive domains showed low reserve on average, but with wide ranges.

Conclusions
Despite similar levels of kidney function, older adults participating in PREPARED had a wide range of measures of reserve in other health domains. Non-renal measures of reserve may be important indicators of capacity of CKD patients to recover after acute care encounters.
Association of periprocedural phentolamine infusion with favorable outcome in patients with chronic kidney disease and chronic coronary syndrome undergoing coronary catheterization: a prospective randomized controlled pilot study
Authors: Hamila Mohamed abo , El Ghawaby Helmy , Zaki Mohamed , Soliman Mohamed , Gabr Khaled 
Published: December 2022

AbstractBackgroundChronic kidney disease (CKD) is a major risk factor for contrast induced acute kidney injury (CI-AKI) in chronic coronary syndrome (CCS) patients undergoing coronary catheterization. We aimed to evaluate the efficacy of phentolamine in prevention of CI-AKI in CKD and CCS patients undergoing percutaneous coronary catheterization for diagnostic angiography ± stenting.MethodsParticipants with CKD and CCS planned for percutaneous coronary catheterization were included, while participants with normal kidney functions were excluded. A consecutive sample of 107 participants (mean age 58.62 ± 8.96 years, 64.5% males) was selected, underwent diagnostic coronary angiography or percutaneous coronary intervention, and received either conventional CI-AKI prevention strategy (group 1) or periprocedural phentolamine and conventional CI-AKI prevention strategy (group 2).ResultsThe percentages of study participants who had CI-AKI were 82.9% for group 1 and 17.1% for group 2, respectively. The incidence rate of CI-AKI was significantly lower in group 2 versus group 1 (p <  0.001). The urine output (ml/kg) and the urine output (ml/hour) within 72 hours post procedure was significantly higher in group 2 versus group 1 (t(105) = − 0.69,p <  0.001, t(105) = − 52.46,p < 0.001, respectively), the peak change in serum creatinine and the percentage of change relative to the baseline serum creatinine at 72 hours post procedure was significantly lower in group 2 versus group 1 (t(102) = 0.2, p 0.018, t(102) = 23.54,p < 0.001, respectively), and the incidence rate of major adverse cardiac and cerebrovascular events within 90 days post procedure was significantly lower in group 2 versus group 1 (t(102) = 1.168,P < 0.001), respectively. There was a statistically significant association of periprocedural phentolamine infusion with prevention of CI-AKI (OR = 0.041, 95% CI 0.0149–0.1128,P < 0.0001).ConclusionOur study highlights the potential role of phentolamine for protection of the kidney in CKD patients planned for coronary catheterization.Trial registrationPan African Clinical Trial Registry Number: PACTR202209493847741.Date of Trial Registration: 22/09/2022.
Usefulness of the skeletal muscle index in postoperative ileus of colorectal cancer patients: a retrospective cohort study
Authors: Sasaki Maho , Fukuoka Tatsunari , Shibutani Masatsune , Sugimoto Atsushi , Maeda Kiyoshi , Ohira Masaichi 
Published: December 2022

Abstract
Background
Postoperative complications of colorectal cancer mainly include infections (surgical site infection, remote infection, etc.), post-operative ileus (POI), and anastomosis leakage. POI reportedly prolongs the hospital stay and increases medical costs. Therefore, predicting POI is very important. There have been some reports on the relationships between sarcopenia and postoperative complications in colorectal cancer patients, but none have been limited to POI. We therefore conducted a retrospective clinical study with a logistic regression analysis to confirm the risk factors for ileus after colorectal cancer surgery.

Methods
We retrospectively analyzed 213 patients who underwent elective oncological colorectal surgery for colorectal cancer from November 2017 to July 2021. The skeletal muscle mass (SMM, kg) was estimated using a whole-body bioelectrical impedance analysis (BIA), and the skeletal muscle index (SMI) was calculated as the SMM/height2. We divided all patients into 2 groups based on a low SMI (male < 8.958 kg/m2, female < 8.443 kg/m2) or normal SMI. Preoperative and intraoperative factors as well as, postoperative outcomes were then compared between the two groups.

Results
The median (range) age of the 213 included patients was 72.0 (33–91) years old. Complications were noted in 96 patients (45.1%), including 21 (9.9%) with POI. There were 68 (31.9%) low SMI patients. POI occurred significantly more frequently in low SMI patients (19.1%) than in normal SMI patients (5.5%) (p = 0.005). In the multivariate analysis, bleeding (p = 0.039) and a low SMI (p = 0.031) were significantly associated with POI. In addition, a propensity score matching analysis was performed to further reduce the selection bias. As a result, a low SMI was the only independent POI predictor among the 78 matched cases.

Conclusion
A preoperative low SMI in colorectal cancer patients was considered a risk factor for POI.
Urinary incontinence and related quality of life among elderly women in Tabas, South Khorasan, Iran
Authors: Najafi Zahra , Morowatisharifabad Mohammad Ali , Jambarsang Sara , Rezaeipandari Hassan , Hemayati Roya 
Published: December 2022

AbstractBackgroundUrinary incontinence (UI) is one of the most common problems in old age that is often seen in women, which causes not only physical problems but also psychological, social, economic problems and poor quality of life. The aim of the present study was to evaluate the UI and related quality of life (QoL) in elderly women.MethodsThis cross-sectional study enrolled 369 women over 60 years old and living in Tabas city, Iran who were selected by cluster random sampling method. The instruments included the International Consultation on Incontinence Questionnaire-Short Form, the International Consultation on Incontinence Questionnaire Urinary Incontinence Quality of Life Module, and a demographic questionnaire. Data analysis was carried out using independent t-test, chi-square, and logistic regression in SPSS software.ResultsThe UI prevalence among participants was 24.9% and stress urinary incontinence was the most common type (40.2% of all elderly patients). The mean UI-related QoL score was 38.04 ± 11.67 from the score range of 22–76. There was a significant positive correlation between UI-related QoL score and UI score (r = 0.585,p < 0.001). Age, body mass index (BMI), constipation, history of cesarean section, hypertension, and the use of angiotensin receptor blockers are factors increasing the odds of having UI in this study population.ConclusionAging, some chronic diseases, high BMI, and the use of some drugs are related to UI prevalence. Also, it is associated with lower QOL among elderly women. Designing appropriate intervention programs, controlling chronic diseases, training in the proper use of drugs, and also some physical exercises can be effective in controlling and improving this common syndrome of old age and promoting their QoL.
Primary adrenal insufficiency and myocarditis in COVID-19 disease: a case report
Authors: Eskandari Delaram , Ziaee Amir , Amirfarhangi Anbardan Abdollah , Zeinali Elahe , Tirkan Atefe 
Published: December 2022

Abstract
Background
COVID-19 has different manifestations from respiratory to GI problems, and some of them are more common, but some are rare. Reporting rare cases can significantly advance our understanding of the disease.

Case presentation
In this case, we report an 18-year-old teenage boy with chest pain and resistant hypotension following COVID-19 infection, finally diagnosed as primary adrenal insufficiency and COVID-19 myocarditis.

Conclusion
Adrenal insufficiency can be life-threatening due to its adverse effects on hemodynamic and electrolyte equilibrium. In addition, COVID-19 induced myocarditis can make the situation more complicated.
Health-related quality of life in inflammatory bowel disease: a comparison of patients receiving nurse-led versus conventional follow-up care
Authors: Alvestad Line , Jelsness-Jørgensen Lars-Petter , Goll Rasmus , Clancy Anne , Gressnes Thomas , Valle Per Christian , Broderstad Ann Ragnhild 
Published: December 2022

Abstract
Background
Inflammatory bowel disease (IBD), consisting of Crohn's disease (CD) and ulcerative colitis (UC), is a chronic disorder with a considerable negative impact on health-related quality of life (HRQoL). During the past decade, IBD nurse specialists have been increasingly involved in follow-up care of IBD outpatients, in a consultative and coordinating role, closely cooperating with gastroenterologists.
Whether patients’ HRQoL differs between nurses’ follow-up care (NF) and conventional follow-up care (CF) has not been widely researched and the aim of this study was to compare two different follow-up regimes with respect to patients’ HRQoL.

Methods
This cross-sectional, multicenter study involved seven centers; five organized as CF, two as NF.

Results
A total of 304 patients aged 18–80 years, 174 females and 130 males, were included, of whom 140 received care under the NF model and 164 under the CF model. Participants in the NF group had a statistically significant higher median total score on the Inflammatory Bowel Disease Questionnaire (IBDQ) (p-value < .001). This pattern could also be seen in the sub-scores of the different IBDQ domains. Despite a trend of higher IBDQ score in all domains in the NF model, the overall result in our study did not reach the limit of 16 points, defined as clinically significant. A higher proportion of NF patients had IBDQ scores defined as remission, as well as a statistically significant higher frequency of outpatient check-ups during a two-year follow-up period.

Conclusions
Nurse-led models are not inferior to conventional models with regards to patient reported HRQoL except in the social domain where the model showed to be clinically significant better. Further studies are needed to advance efforts to implement these models and increase access to IBD care.
Development of a yeast whole-cell biocatalyst for MHET conversion into terephthalic acid and ethylene glycol
Authors: Loll-Krippleber Raphael , Sajtovich Victoria A. , Ferguson Michael W. , Ho Brandon , Burns Andrew R. , Payliss Brandon J. , Bellissimo Joseph , Peters Sydney , Roy Peter J. , Wyatt Haley D. M. , Brown Grant W. 
Published: December 2022

Abstract
Background
Over the 70 years since the introduction of plastic into everyday items, plastic waste has become an increasing problem. With over 360 million tonnes of plastics produced every year, solutions for plastic recycling and plastic waste reduction are sorely needed. Recently, multiple enzymes capable of degrading PET (polyethylene terephthalate) plastic have been identified and engineered. In particular, the enzymes PETase and MHETase from Ideonella sakaiensis depolymerize PET into the two building blocks used for its synthesis, ethylene glycol (EG) and terephthalic acid (TPA). Importantly, EG and TPA can be re-used for PET synthesis allowing complete and sustainable PET recycling.

Results
In this study we used Saccharomyces cerevisiae, a species utilized widely in bioindustrial fermentation processes, as a platform to develop a whole-cell catalyst expressing the MHETase enzyme, which converts monohydroxyethyl terephthalate (MHET) into TPA and EG. We assessed six expression architectures and identified those resulting in efficient MHETase expression on the yeast cell surface. We show that the MHETase whole-cell catalyst has activity comparable to recombinant MHETase purified from Escherichia coli. Finally, we demonstrate that surface displayed MHETase is active across a range of pHs, temperatures, and for at least 12 days at room temperature.

Conclusions
We demonstrate the feasibility of using S. cerevisiae as a platform for the expression and surface display of PET degrading enzymes and predict that the whole-cell catalyst will be a viable alternative to protein purification-based approaches for plastic degradation.