bluuebunny/crossref_metadata_2025_split huggingface dataset:
PbrBZR1 interacts with PbrARI2.3 to mediate brassinosteroid-regulated pollen tube growth during self-incompatibility signaling in pear
Authors: Wang Yicheng , Liu Panpan , Cai Yiling , Li Yu , Tang Chao , Zhu Nan , Wang Peng , Zhang Shaoling , Wu Juyou 
Published: April 2023

Abstract
S-RNase-mediated self-incompatibility (SI) prevents self-fertilization and promotes outbreeding to ensure genetic diversity in many flowering plants, including pear (Pyrus sp.). Brassinosteroids (BRs) have well-documented functions in cell elongation, but their molecular mechanisms in pollen tube growth, especially in the SI response, remain elusive. Here, exogenously applied brassinolide (BL), an active BR, countered incompatible pollen tube growth inhibition during the SI response in pear. Antisense repression of BRASSINAZOLE-RESISTANT1 (PbrBZR1), a critical component of BR signaling, blocked the positive effect of BL on pollen tube elongation. Further analyses revealed that PbrBZR1 binds to the promoter of EXPANSIN-LIKE A3 (PbrEXLA3) to activate its expression. PbrEXLA3 encodes an expansin that promotes pollen tube elongation in pear. The stability of dephosphorylated PbrBZR1 was substantially reduced in incompatible pollen tubes, where it is targeted by ARIADNE2.3 (PbrARI2.3), an E3 ubiquitin ligase that is strongly expressed in pollen. Our results show that during the SI response, PbrARI2.3 accumulates and negatively regulates pollen tube growth by accelerating the degradation of PbrBZR1 via the 26S proteasome pathway. Together, our results show that an ubiquitin-mediated modification participates in BR signaling in pollen and reveal the molecular mechanism by which BRs regulate S-RNase-based SI.
“Deservingness” and Public Support for Universal Public Goods: A Survey Experiment
Authors: Gift Thomas , Lastra-Anadón Carlos X 
Published: April 2023

AbstractVoters support less spending on means-tested entitlements when they perceive beneficiaries as lacking motivation to work and pay taxes. Yet do concerns about the motivations of “undeserving” beneficiaries also extend to universal public goods (UPGs) that are free and available to all citizens? Lower spending on UPGs poses a particular trade-off: it lessens subsidization of “unmotivated” beneficiaries, but at the expense of reducing the ideal levels of UPGs that voters personally can access. Studies suggest that individuals will sacrifice their preferred amounts of public goods when beneficiaries who do not pay taxes try to access these goods, but it is unclear whether they distinguish based on motivations. To analyze this question, we field a nationally representative survey experiment in the UK that randomly activates some respondents to think about users of the country's universal National Health Service as either “motivated” or “unmotivated” noncontributors. Although effect sizes were modest and spending preferences remained high across the board, results show that respondents support less spending on the NHS when activated to think of users as “unmotivated” noncontributors. These findings suggest how the deservingness heuristic may shape public attitudes toward government spending, regardless of whether benefits are targeted or universal.
Money Market Disconnect
Authors: Ballensiefen Benedikt , Ranaldo Angelo , Winterberg Hannah 
Published: April 2023

Abstract
A repurchase agreement (repo) is a source of cash and collateral. We document that the money market is more segmented when the collateral motive prevails. Two crucial aspects of the central bank framework lead to this disconnect: banks’ access to the central bank’s deposit facility and assets’ eligibility for quantitative easing (QE). We show that repo rates lent by banks with access to the deposit facility and secured by QE eligible assets are more collateral-driven and disconnected from funding-based money market rates. Our results are relevant for different monetary policies and have suggestive implications for the monetary policy pass-through.
Authors have furnished an Internet Appendix, which is available on the Oxford University Press Web site next to the link to the final published paper online.
Clinical and Electroencephalographic Predictors of Seizures and Status Epilepticus in 12,450 Critically Ill Adults: A Retrospective Cohort Study
Authors: Snider Samuel B. , Fong Michael W. K. , Nolan Neal M. , Ruiz Andres Rodriguez , Wang Wei , LaRoche Suzette , Hirsch Lawrence J. , Lee Jong W. ,   for the Critical Care EEG Monitoring Research Consortium
Published: April 2023

OBJECTIVES:
Status epilepticus (SE) is associated with significantly higher morbidity and mortality than isolated seizures. Our objective was to identify clinical diagnoses and rhythmic and periodic electroencephalogram patterns (RPPs) associated with SE and seizures.

DESIGN:
Retrospective cohort study.

SETTING:
Tertiary-care hospitals.

SUBJECTS:
Twelve thousand four hundred fifty adult hospitalized patients undergoing continuous electroencephalogram (cEEG) monitoring in selected participating sites in the Critical Care EEG Monitoring Research Consortium database (February 2013 to June 2021).

INTERVENTIONS:
Not applicable.

MEASUREMENTS AND MAIN RESULTS:
We defined an ordinal outcome in the first 72 hours of cEEG: no seizures, isolated seizures without SE, or SE (with or without isolated seizures). Composite groups included isolated seizures or SE (AnySz) and no seizure or isolated seizures. In this cohort (mean age: 60 ± 17 yr), 1,226 patients (9.8%) had AnySz and 439 patients (3.5%) had SE. In a multivariate model, factors independently associated with SE were cardiac arrest (9.2% with SE; adjusted odds ratio, 8.8 [6.3–12.1]), clinical seizures before cEEG (5.7%; 3.3 [2.5–4.3]), brain neoplasms (3.2%; 1.6 [1.0–2.6]), lateralized periodic discharges (LPDs) (15.4%; 7.3 [5.7–9.4]), brief potentially ictal rhythmic discharges (BIRDs) (22.5%; 3.8 [2.6–5.5]), and generalized periodic discharges (GPDs) (7.2%; 2.4 [1.7–3.3]). All above variables and lateralized rhythmic delta activity (LRDA) were also associated with AnySz. Factors disproportionately increasing odds of SE over isolated seizures were cardiac arrest (7.3 [4.4–12.1]), clinical seizures (1.7 [1.3–2.4]), GPDs (2.3 [1.4–3.5]), and LPDs (1.4 [1.0–1.9]). LRDA had lower odds of SE compared with isolated seizures (0.5 [0.3–0.9]). RPP modifiers did not improve SE prediction beyond RPPs presence/absence (p = 0.8).

CONCLUSIONS:
Using the largest existing cEEG database, we identified specific predictors of SE (cardiac arrest, clinical seizures prior to cEEG, brain neoplasms, LPDs, GPDs, and BIRDs) and seizures (all previous and LRDA). These findings could be used to tailor cEEG monitoring for critically ill patients.
Safety of glucagon-like peptide-1 receptor agonists for weight management in adults, adolescents, and children with obesity: a scoping review
Authors: Baden Christoffer S. , Andersen Jon T. , Christensen Mikkel B. , Gade Christina 
Published: April 2023

Summary
As obesity continues to be a global health challenge presenting various negative impacts on health outcomes and healthcare costs, there is a growing need for pharmacological interventions to address the issue. Glucagon-like peptide-1 receptor agonists have shown potential in treating obesity and reducing the risk of type 2 diabetes, but there is a lack of studies comparing adverse events across different populations. This review intends to indirectly compare the adverse events of available glucagon-like peptide-1 receptor agonist pharmaceuticals for treating overweight or obesity in adults, adolescents, and children.
Integration of three-dimensional printing model into navigator-assisted surgery on fibrous dysplasia patient
Authors: Huang Chao-Hsin , Chen Meng-Ta , Lee Su-Shin 
Published: April 2023

Abstract
Fibrous dysplasia refers to a chronic bone deformity caused by abnormal fibrotic and osseous tissue replacing normal ones. Craniofacial fibrous dysplasia can lead to facial asymmetry, which can cause misalignment of jaw, nasal airway congestion, proptosis, and vision loss. To improve facial asymmetry and preserve optic nerve function, operation is indicated. However, pathological bone at the affected ocular area can be really close to the optic nerve. Complicated and limited surgical field increased operation difficulty. Thus, precise operation is required for minimizing risk of optic nerve injury. Navigator-assisted surgery can be applied to these patients with optic nerve compression. In addition, we proposed integrating three-dimensional computer simulation into preoperational planning in navigator-assisted surgery to improve precision. Here, we present a case diagnosed as craniofacial dysplasia undergoing navigator-assisted surgery with integration of computer simulation.
Utilization of a 3D Printed Simulation Training Model to Improve Microsurgical Training
Authors: Geoghegan Luke , Papadopoulos Dimitrios , Petrie Nicola , Teo Isabel , Papavasiliou Theodora 
Published: April 2023

Background:
Simulation is integral to the development and maintenance of micro- surgical skills. Several simulation models have been described ranging from bench- top to live animal models. High fidelity models are often burdened by cost and ethical issues limiting widespread implementation. This study aims to determine the feasibility of a microsurgical training platform using the Konjac noodle model.

Methods:
A prospective cohort study was conducted at our institution. A progressive microsurgical training curriculum was developed. A bespoke three-dimensional printed training platform was produced to enable residents to record training and assessment tasks. Microsurgical skills were blindly assessed before and after completing the training program using the University of Western Ontario Microsurgical Skills Assessment instrument.

Results:
Plastic surgery residents at various stages of training were recruited (n = 10). A significant improvement in vessel preparation from a pre-training median of 3 (IQR 2 -4) versus a post-training of 4 (IQR 3 -5, P = 0.0035) and suturing with a pre-training median of 3 (IQR 2 -4) versus a post-training of 4 (IQR 3 -5, P = 0.0047) domains of the University of Western Ontario Microsurgical Skills Assessment score was demonstrated after completion of the training program. There was a significant improvement in the global rating score (3 ± 1 versus 5 ± 1, P = 0.0045). Participants felt more confident performing a microsurgical anastomosis following the training program.

Conclusion:
The use of the Konjac noodle model and video-based assessment using a three-dimensional printed model is an effective teaching tool that improves resident's microsurgical skills.
Mental Health Conditions and Health-related Quality of Life Changes after Reduction Mammaplasty in Younger Patients
Authors: White Ava G. , Nuzzi Laura C. , McNamara Catherine T. , Nussbaum Lisa S. , Cappitelli Alex T. , DiVasta Amy D. , Labow Brian I. 
Published: April 2023

Background:
Reduction mammaplasty is increasingly common in younger patients with macromastia. Unfortunately, a recent surge in mental health disorders has been documented in this population. It is unknown how mental health disorders affect patients undergoing reduction mammaplasty. This study examines the impact of concurrent mental health conditions on health-related quality of life outcomes after reduction mammaplasty.

Methods:
A prospective cohort study was performed on patients aged 12–21 years undergoing reduction mammaplasty. Patients were assigned to unaffected or affected (baseline mental health condition) cohorts based on psychological history. Patients completed the Short-form-36, Rosenberg Self-esteem Scale, Eating Attitudes Test 26, and Breast-related Symptoms Questionnaire at baseline and postoperatively.

Results:
A total of 250 patients were included (81 affected and 169 unaffected). Mean age at surgery was 17.9 ± 2.0 and 18.1 ± 1.8 years for affected and unaffected patients, respectively. Anxiety (n = 59, 23.6%) and depression (n = 38, 15.2%) were the most prevalent conditions. Affected patients were outscored by controls at baseline and postoperatively in most measures. However, significant score improvements were also reported in the affected cohort. In fact, the magnitude of score improvements observed in both cohorts were similar (P > 0.05, all).

Conclusions:
Baseline mental health conditions are common in young patients presenting for reduction mammaplasty. After surgery, health-related quality of life in affected patients remains below unaffected peers; however, significant and similar gains are achieved. We advise providers to recommend mental health treatment to affected patients, but not preclude otherwise appropriate candidates from surgery.
Correction of Lacrimal Gland Ptosis in Blepharoplasty: A Systematic Review
Authors: Henares Chavarino Ángel Andrés , Estiragués Cerdá María , Ros Magallón Andrés , Vicente Ruiz Miriam , Arroyo Pérez Íñigo , Bazán Álvarez Antonio 
Published: April 2023

Purpose:
Lacrimal gland ptosis has a prevalence of 10% to 15% in Caucasian patients, reaching up to 60% in older age. Its involuntary resection during blepharoplasty carries the potential risk of compromising corneal lubrication. The purpose of this systematic review is to check whether there is a consensus in the literature regarding the surgical procedure of choice and which outcomes and complications have been observed.

Methods:
A systematic review was carried out following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. A search was carried out in the Medline, Scopus, and Cochrane databases in March 2022.

Results:
A total of 16 studies involving 483 patients with lacrimal gland ptosis have been included. In 90.06% of patients, resuspension or direct refixation of the gland to the lacrimal fossa with suture to the orbital periosteum was performed. Follow up has been inconsistent, with an average of 18 months. Regarding complications, 5 recurrences and only 2 patients with persistent dry eye were observed.

Conclusions:
In general, the evidence is sparse. Nevertheless, repair of lacrimal gland ptosis is a relatively simple, reproducible, and safe surgical technique, with a low likelihood of recurrence, severe, or persistent complications. A classification is proposed for both the grading of ptosis and its treatment.
A Cross-Sectional Study of the Characteristics Associated With Chronic Pain Documentation on the Problem List
Authors: Rylee Tina L. , Copenhaver David , Drake Christiana , Joseph Jill 
Published: April 2023

ABSTRACT
Chronic pain is often elusive because of its specific diagnosis and complex presentation, making it challenging for healthcare providers to develop safe and effective treatment plans. Experts recommend a multifaceted approach to managing chronic pain that requires interdisciplinary communication and coordination. Studies have found that patients with a complete problem list receive better follow-up care. This study aimed to determine the factors associated with chronic pain documentation in the problem list. This study included 126 clinics and 12,803 patients 18 years or older with a chronic pain diagnosis within 6 months before or during the study period. The findings revealed that 46.4% of the participants were older than 60 years, 68.3% were female, and 52.1% had chronic pain documented on their problem list. Chi-square tests revealed significant differences in demographics between those who did and did not have chronic pain documented on their problem list, with 55.2% of individuals younger than 60 years having chronic pain documented on their problem list, 55.0% of female patients, 60.3% of Black non-Hispanic people, and 64.8% of migraine sufferers. Logistic regression analysis revealed that age, sex, race/ethnicity, diagnosis type, and opioid prescriptions were significant predictors of chronic pain documentation on the problem list.
Experience and Hospital Context Influence Fall Prevention Practice by Physical Therapists: A Survey Study
Authors: Crick James P. , Juckett Lisa , Salsberry Marka , Quatman Carmen , Quatman-Yates Catherine C. 
Published: April 2023

Abstract

Background:
Falls in and following hospitalization are common and problematic. Little is understood about the factors that impede or promote effective implementation of fall prevention practices.

Purpose and Relevance:
Physical therapists are commonly consulted for acute care patients at risk for falling. The purpose of this study is to understand therapist perceptions of their effectiveness in fall prevention and to explore the impact of contextual factors on practice patterns to prevent falls surrounding hospitalization.

Methods:
Survey questions were tailored to the constructs of hospital culture, structural characteristics, networks and communications, and implementation climate, in addition to inquiries regarding practice patterns and attitudes/beliefs.

Results:
Overall, 179 surveys were analyzed. Most therapists (n = 135, 75.4%) affirmed their hospital prioritizes best practices for fall prevention, although fewer agreed that therapists other than themselves provide optimal fall prevention intervention (n = 105, 58.7%). Less practice experience was associated with greater odds of affirming that contextual factors influence fall prevention practice (OR 3.90, p < .001). Respondents who agreed that their hospital system prioritizes best practices for fall prevention had 14 times the odds of believing that their system prioritizes making improvements (p = .002).

Conclusions/Implications:
As experience influences fall prevention practice, quality assurance and improvement initiatives should be used to ensure minimum specifications of practice.
Frequency of Goal Setting Contact with Physical Therapists Is Associated with Orthotist’s Perceived Skill Level
Authors: Kenworthy Sally , Reno Ariel , Roy Tara , Glahn Castille Megan 
Published: April 2023

ABSTRACT

Introduction
Effective communication is key to the development of a successful interdisciplinary team, and effective communication cannot be achieved without an accurate understanding of role awareness. Communication within interdisciplinary teams may be particularly important for orthotists given their highly specialized scope of practice, the limited public awareness of the profession, and relatively recent increases to minimum education requirements. Because physical therapists (PTs) and orthotists commonly work together to restore mobility, the purpose of this study was to determine if there are factors associated with the perceived value of orthotists as members of the health care team among PTs.

Materials and Methods
This study consisted of a cross-sectional survey assessing demographic characteristics and four value variables. The survey was distributed via email using snowball sampling to health care team members. Responses from PTs were analyzed through a series of statistical testing for significant correlations of the demographic characteristics and value variables.

Results
A total of 68 responses from PTs were included in the final analysis. Mutual patient goal setting contact showed a statistically significant relationship with frequency of contact and the perceived skill level of orthotists. The mean orthotist skill level was 86.57 (±10.24, min = 59, max = 100). The frequency of mutual patient goal setting contact was higher for PTs who were younger, had a higher level of education, and fewer years of experience.

Conclusions
Despite its rich history, orthotics may be considered relatively new as a profession, and orthotists are often still establishing their role within a team setting. Mutual patient goal setting may provide a key opportunity for orthotists to increase awareness of their skill set and demonstrate their value as professional members of the health care team. Interprofessional education is another opportunity to increase role awareness and may explain why younger PTs with higher levels of education and fewer years of experience were more likely to set mutual patient goals with orthotists.

Clinical Relevance
The results of this study show that engaging in mutual patient goal setting with PTs may be an avenue for orthotists to demonstrate their skills, knowledge, and, ultimately, their value.
Performance of Surface Topography Systems in Scoliosis Management: A Narrative Review
Authors: Bidari Shahrbanoo , Kamyab Mojtaba , Kakavand Reza , Komeili Amin 
Published: April 2023

ABSTRACT

Introduction
The aesthetic appearance of the torso is the foremost concern of scoliotic patients, which, if not addressed, could adversely affect their life quality. The Cobb angle limitation in describing three-dimensional (3D) deformities of the spine and its associated ionizing radiation motivated clinicians to implement noninvasive surface topography (ST) methods for monitoring scoliosis. This study aimed to review the accuracy of the most commonly used ST systems and their ST parameters in predicting and monitoring scoliosis.

Materials and Methods
The scientific databases were used to search for the studies considering the validity and reliability of different ST methods published in English from 1970 to July 2020.

Results
Of 221 found publications, 41 journal publications were evaluated for this review. The accuracy of ST methods was affected by light source quality, acquisition time, and postural sway. Some ST parameters resulted in a high correlation with radiographic measurements and classified scoliosis deformities into mild, moderate, and severe. Some ST parameters may not effectively predict the Cobb angle but could monitor curve progression accurately. Representing spine deformities in the lumbar section and subjects with higher body mass index was associated with more significant errors due to thicker soft tissues around the spine.

Conclusions
According to the present review, ST systems could complement radiography measurements and provide valuable insights into different aspects of internal and external deformity; however, they have not reached a state that can replace radiography in the management of scoliosis.

Clinical Relevance
The present study helps clinicians choose the most appropriate ST methods for predicting and monitoring scoliotic curves and torso asymmetry evaluations.