bluuebunny/crossref_metadata_2025_split huggingface dataset:
PEGylated exenatide injection (PB-119) improves beta-cell function and insulin resistance in treatment-naïve type 2 diabetes mellitus patients
Authors: Liu Xu , Song Ling , Zhang Yuanhui , Li Haiyan , Cui Cheng , Liu Dongyang 
Published: September 2023

Objective: PB-119, a PEGylated exenatide injection, is a once-weekly glucagon-like peptide-1 receptor agonist. In the present study, we aimed to evaluate the effects of PB-119 on insulin resistance and beta-cell function in Chinese patients with type 2 diabetes mellitus (T2DM) to uncover its antidiabetic characteristics.Methods: A total of 36 Chinese T2DM patients were randomized to receive 25 μg and 50 μg PB-119 once weekly and exenatide (5–10 μg injected under the skin 2 times a day adjusted by the doctor) for 12 weeks. Oral mixed meal tolerance tests were conducted before the study and on Day 79. The data were fitted to estimate beta-cell function and insulin sensitivity parameters using the SAAM II package integrating the oral minimal model (OMM), which was compared with Homeostatic Model Assessment (HOMA) analysis results.Results: Exenatide or PB-119 treatment, compared with their baseline, was associated with higher beta-cell function parameters (φb, φs and φtot), disposition index, insulin secretion rates, and a lower glucose area under the curve. High-dose PB-119 also has a higher insulin resistance parameter (SI) than the baseline, but HOMA-IR did not. For the homeostatic model assessment parameters, HOMA-IR showed no statistically significant changes within or between treatments. Only high-dose PB-119 improved HOMA-β after 12 weeks of treatment.Conclusion: After 12 weeks of treatment, PB-119 decreased glycemic levels by improving beta-cell function and insulin resistance.
Culture and the assumptions about appearance and reality: a scientometric look at a century of research
Authors: Carollo Alessandro , Stanzione Alfonso Maria , Fong Seraphina , Gabrieli Giulio , Lee Albert , Esposito Gianluca 
Published: September 2023

IntroductionPeople represent the world in terms of two constructs: how something appears on the surface (appearance) and what it is underneath that surface (reality). Both constructs are central to various bodies of literature. What has not been done, however, is a systematic look at this collection of literature for overarching themes. Motivated by this research gap, the present scientometric review aimed to identify the common themes that penetrate through a century of scholarly work on appearance and reality. In doing so, this review also sketched a scientometric outline of the international network, pinpointing where the work was carried out.MethodsWith CiteSpace software, we computed an optimized document co-citation analysis with a sample of 4,771 documents (1929–2022), resulting in a network of 1,785 nodes.Results and discussionWe identified impactful publications, summarized major intellectual movements, and identified five thematic clusters (“Perception of Counseling Services”, “Appearance and Reality in Sociocultural Evolution,” “Cultural Heritage and Identity,” “Media and Culture,” and “Cultural Identity”), all with theoretical and pragmatic implications which we discuss. A deeper look at these clusters reveals new empirical questions and promising directions for future research.
Reliability and validity of the Chinese version of the Athens insomnia scale for non-clinical application in Chinese athletes
Authors: Tan Chenhao , Wang Jinhao , Cao Guohuan , Chen Chao , Yin Jun , Lu Jiaojiao , Qiu Jun 
Published: September 2023

PurposeThis study aimed to revise and examine the reliability and validity of the Chinese version of the Athens Insomnia Scale for Non-clinical Application (AIS-NCA) among Chinese athletes. Additionally, the study tested the scale in non-athlete individuals with similar sleep management practices to further analyze its cultural specificity among Chinese athletes and make preliminary inferences about its applicability in other Chinese populations.MethodsFour hundred twenty-six Chinese professional athletes and 779 high school students participated in this research. Both athletes and students were divided into two parallel groups for exploratory and confirmatory factor analyses. Additionally, three athlete samples and one student sample were established for reliability and validity assessments. Among athletes, the Pittsburgh Sleep Quality Index, the Epworth Sleepiness Scale, the Athlete Sleep Screening Questionnaire, and the Warwick-Edinburgh Mental Well-Being Scale were employed to evaluate convergent and discriminant validity. Re-test reliability was evaluated at intervals of 1 and 2 weeks. In the case of students, convergent and discriminant validity were tested using the Pittsburgh Sleep Quality Index and the General Self-Efficacy Scale, with re-test reliability assessed at two-week intervals.ResultsThe Chinese version of the AIS-NCA consists of six items, categorized into two dimensions: sleep problems and daytime functioning. This structure explained 65.08% (athletes) and 66.22% (students) of the variance. Confirmatory factor analysis revealed good model fit, with values of χ2/df = 2.217, CFI = 0.975, AGFI = 0.929, TLI = 0.953, and RMSEA = 0.076 among athletes, and χ2/df = 3.037, CFI = 0.979, AGFI = 0.947, TLI = 0.961, and RMSEA = 0.072 among students. The scale demonstrated a reasonable degree of measurement invariance. The overall scale and two subscales exhibited strong reliability and validity among athletes. Similar results in terms of reliability and validity were also observed within the student sample.ConclusionThe Chinese version of the AIS-NCA shows promise as an assessment tool for evaluating the sleep quality of Chinese athletes. It effectively captures both sleep-related concerns and daytime functionality within the athlete population. The scale demonstrates solid reliability and validity in professional athletes and holds potential for application across various other demographic groups in China.
Machiavellianism and psychopathy affect sleep quality in people with affective disorders and mentally healthy individuals
Authors: Schönthaler Elena M. D. , Dalkner Nina , von Lewinski Dirk , Reininghaus Eva Z. , Baranyi Andreas 
Published: September 2023

IntroductionDeteriorated sleep quality is a predisposing factor and symptom of affective disorders (AD). It is important to investigate factors driving the relationship between sleep and AD, such as personality traits. Previous research has shown that personality traits such as the Dark Triad personality traits (DT) narcissism, Machiavellianism, and psychopathy are associated with sleep problems and AD. The current study examined the moderating influence of the DT in the relationship between AD [versus healthy controls (HC)] and sleep quality.MethodsData of 657 individuals (267 HC, 390 AD; 483 female, 166 male, eight diverse; Mage = 34.87, SDage = 13.86) were collected in an online survey, which administered the Pittsburgh Sleep Quality Index and the Short Dark Triad questionnaire.ResultsModeration analyses controlling for age and gender revealed that Machiavellianism (b = −0.76, p &lt; 0.05, R2 = 0.35) and psychopathy (b = −1.15, p &lt; 0.05, R2 = 0.35), but not narcissism (b = −0.20, p = 0.620, R2 = 0.35), had a negative effect on sleep quality. Specifically, this effect is more pronounced in the HC group, but sleep quality is generally worse in AD.ConclusionOur findings indicate that Machiavellianism and psychopathy should be considered in the prevention and treatment of AD-associated sleep problems. Particularly, monitoring these traits could help to implement timely measures for the prevention of sleep problems, such as psychoeducation and sleep hygiene. The results highlight the role of personality in the aetiopathogenesis of AD and require further differentiation to examine the underlying pathways between the DT, sleep, and AD.
Zoonotic tuberculosis in a high bovine tuberculosis burden area of Ethiopia
Authors: Ayalew Sosina , Habtamu Getinet , Melese Fantanesh , Tessema Bamlak , Ashford Roland T. , Chothe Shubhada K. , Aseffa Abraham , Wood James L. N. , Berg Stefan , Mihret Adane ,   for the ETHICOBOTS Consortium
Published: September 2023

BackgroundTuberculosis (TB) is a major cause of ill health and one of the leading causes of death worldwide, caused by species of the Mycobacterium tuberculosis complex (MTBC), with Mycobacterium tuberculosis being the dominant pathogen in humans and Mycobacterium bovis in cattle. Zoonotic transmission of TB (zTB) to humans is frequent particularly where TB prevalence is high in cattle. In this study, we explored the prevalence of zTB in central Ethiopia, an area highly affected by bovine TB (bTB) in cattle.MethodA convenient sample of 385 patients with pulmonary tuberculosis (PTB, N = 287) and tuberculous lymphadenitis (TBLN, N = 98) were included in this cross-sectional study in central Ethiopia. Sputum and fine needle aspirate (FNA) samples were obtained from patients with PTB and TBLN, respectively, and cultures were performed using BACTEC™ MGIT™ 960. All culture positive samples were subjected to quantitative PCR (qPCR) assays, targeting IS1081, RD9 and RD4 genomic regions for detection of MTBC, M. tuberculosis and M. bovis, respectively.ResultsTwo hundred and fifty-five out of 385 sampled patients were culture positive and all were isolates identified as MTBC by being positive for the IS1081 assay. Among them, 249 (97.6%) samples had also a positive RD9 result (intact RD9 locus) and were consequently classified as M. tuberculosis. The remaining six (2.4%) isolates were RD4 deficient and thereby classified as M. bovis. Five out of these six M. bovis strains originated from PTB patients whereas one was isolated from a TBLN patient. Occupational risk and the widespread consumption of raw animal products were identified as potential sources of M. bovis infection in humans, and the isolation of M. bovis from PTB patients suggests the possibility of human-to-human transmission, particularly in patients with no known contact history with animals.ConclusionThe detected proportion of culture positive cases of 2.4% being M. bovis from this region was higher zTB rate than previously reported for the general population of Ethiopia. Patients with M. bovis infection are more likely to get less efficient TB treatment because M. bovis is inherently resistant to pyrazinamide. MTBC species identification should be performed where M. bovis is common in cattle, especially in patients who have a history of recurrence or treatment failure.
Priority quality traits for gendered sweetpotato breeding in Mozambique
Authors: Mayanja Sarah , Tinyiro Samuel Edgar , Ogwal David Martin , Makunde Godwill , Naico Abdul , Nakitto Mariam , Ssali Reuben , Andrade Maria 
Published: September 2023

IntroductionSweetpotato breeders strive to develop varieties that address productivity challenges farmers face in sub-Saharan Africa (SSA). However, adoption of these varieties is low, partly attributed to limited attention to attributes desired by the end-users.MethodsThis study sought to identify the key traits preferred by eight women processors and 426 consumers (180 male, 246 female) in Manhiça, Marracuene and Maputo districts, Mozambique. Processing diagnostics and consumer studies evaluated two local varieties (‘Lilas’, ‘N’santimuni’) and two improved varieties (‘Alisha’, ‘Irene’). Data from processors were analyzed using content analysis and summary statistics. Consumer hedonic data were analyzed using clustering and regression models, while Penalty analysis and Multiple correspondence analysis were performed for the Just-about-right and Check-all-that-apply tests respectively.ResultsProcessors prioritized mealiness, sweet taste, not fibrous, good sweetpotato smell, ease of peeling, easy to cook and good appearance for the boiled root. ‘N’santimuni’ was the most preferred variety for processing. Consumers preferred ‘N’santimuni’ and ‘Lilas’ because of their high dry matter, pleasant sweetpotato smell, firmness in the hand, smoothness when eating and sweet taste. ‘Alisha’ and ‘Irene’ were the most penalized for low scores on sweetness, mealiness, and firmness. Women consumed sweetpotato more frequently than men and had better discernment of sweet taste, homogeneity and colour. Also, youth and more educated consumers disliked improved varieties more than adults and lower income consumers.DiscussionProcessors and consumers strongly indicated their preference and importance of quality attributes such as mealiness, sweet taste, firmness for boiled sweetpotato. However, such traits are rarely included in breeding designs. Breeding programs can thus be enhanced by studies of biophysical and chemical parameters of sweetpotato. This will enable quantification incorporation of these quality attributes.
Genome-Wide Analysis of Alternative Splicing Events Responding to High Temperatures in Populus tomentosa Carr.
Authors: Wang Xue , Wang Yan , Wang Ruixue , Gong Longfeng , Wang Lei , Xu Jichen 
Published: September 2023

Through alternative splicing (AS) processes, eukaryotic genes can generate a variety of transcription isoforms that lower the expression levels of the normal transcripts or result in diversity in the genes’ activities. Then, AS plays a significant role in the control of plant development and stress tolerance. In this study, we analyzed Populus tomentosa Carr. TC1521’s AS episodes in response to high temperatures. The samples treated at 25 °C, 30 °C, 35 °C, and 40 °C produced a total of 10,418, 11,202, 9947, and 14,121 AS events, respectively, which responded to 4105, 4276, 4079, and 4915 genes, respectively, representing 9.84%, 10.25%, 9.78%, and 11.78% of the total number of transcribed genes, respectively. The most common AS pattern, accounting for 42.31% to 51.00% of all AS events, was intron retention (IR), followed by exon skipping (ES), which accounted for 9.14% to 10.23% of all AS events. respectively. According to sequence characterization, AS was negatively correlated with guanine-cytosine content (GC content) but favorably correlated with intron length, exon number, exon length, and gene transcription level. Compared to treatment at 25 °C, 2001 distinct AS genes were discovered at 40 °C. They were primarily enriched in the RNA degradation pathway and the valine, leucine, and isoleucine degradation route, according to (gene ontology) GO and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis. These findings demonstrated how the AS process might be severely impacted by high temperatures. In addition, the information on AS isoforms helped us comprehend stress-resistance mechanisms in new ways and completed molecular design breeding.
Uso indiscriminado de pílula do dia seguinte e seu aspecto socioeconômico
Authors: Bottoli Isabella Maria França , Trevizol João Henrique , Koshikumo Andressa Akiko , Colmiran Vagner Luiz , Canton Barbara de Abreu , Pinto Mariana Santos , Moreira Marina Lopes Resende Coelho , Cavalcante Lina Borges , Caetano Ítalo Pauliram Candeia , Nogueira Pedro Henrique de Lima , De Paula Fernanda Pimpão , Curado Aniélly Cristina Guimarães , Borges Nathália Correia Romeiro , De Sousa Daiane Aparecida Soares , Duarte Aline de Amorim 
Published: September 2023

Introdução: O trabalho aborda a pílula anticoncepcional do dia seguinte como um método contraceptivo de emergência, destacando sua utilização inadequada por mulheres em situação socioeconômica desfavorável. Métodos: Trata-se de uma revisão de literatura, utilizando as bases de dados SciELO e PubMed para pesquisa dos trabalhos de 2003 a 2023. Discussão: O estudo enfatiza que o conhecimento sobre a pílula do dia seguinte é disseminado entre adultos e adolescentes sexualmente ativos, porém, o entendimento sobre seu uso seguro é insuficiente. A orientação adequada é fundamental para evitar efeitos colaterais prejudiciais, interações medicamentosas e uso excessivo. Além disso, a pesquisa destaca que esse método não oferece proteção contra infecções sexualmente transmissíveis (ISTs) e enfatiza a importância de seu uso com cautela e preferencialmente com prescrição médica. Conclusão: Em síntese, o estudo ressalta a relevância de disseminar informações corretas sobre o uso da pílula do dia seguinte, especialmente entre mulheres em situação socioeconômica desfavorável, para evitar seu uso inadequado e os riscos associados a ele.
جمالية التلقي في المسرح الجزائري ورهان المتلقي الافتراضي، قراءة في مسرحية "قف" لمحمد بن قطاف
Authors: بلحوالة سهيلة 
Published: September 2023

الملخص :
يوحي التأمل في عالمي المسرح و المتلقي إلى تواجد خيط رابط أو علاقة محتملة بينهما ، لأن المسرح فن يندرج في إطار الحقل الإنساني ، و التلقي ممارسة تشير إليها زوايا من المجتمع و هي تتموقع في سياق هذا الحقل .
فالعلاقة بين المسرح الجزائري و المتلقي تزكيها طبيعة المسرح الذي يقوم على أساس اجتماعي يبني وجوده و استمراريته من المتلقي ، إذ لا يمكن أن نتصور مسرحا حقيقيا إلا باقترانه بجمهور فما يعمق المسافة بين المسرح و بين المتلقي هو كون الأول ظاهرة يمكن أن تصبح –عن طريق الاكتساب- في متناول كافة الناس و يبقى الثاني ظاهرة تستدعي حضور دوافع و أسس لدى ممارسيها ، تتمثل في الرصيد الثقافي و المعرفي الذي يسمح لهم بالتدخل في اللحظة التي تعبر فيها كل أشكال الظواهر عن تعدد المعاني لدى المتلقي . كل هذه العناصر توحي إذن بلا جدوى إلغاء الخيوط الواصلة بين المسرح و المتلقي.
من هنا ارتأينا طرح إشكالية هذه المداخلة في تسلسل يجمع بين جمالية التلقي في المسرح الجزائري و ركزنا على دراسة تلقي مسرحية "قف" لمحمد بن قطاف في فترة السبعينات و ربطنا ذلك بمناقشة متلقي افتراضي يراهن على إثبات شرعيته اليوم إذن :
- كيف تأسست العلاقة بين مسرحية قف و المتلقي الجزائري في فترة السبعينات و إلى أي مدى استطاع امحمد بن قطاف أن يبدع عملا مسرحيا وجد متلقي يكمل معناه و يثبت وجوده ؟.
أو بالأحرى :
- كيف يمكن للمسرح الجزائري اليوم أن يثبت شرعية المتلقي الافتراضي في ظل ما يسمى بالآنية و المباشرة ؟.أو بمعنى آخر
- هل يمكننا اعتبار المتلقي الافتراضي متلقي جديد يفرضه شكل العمل المسرحي الجديد و تمليه ضرورة يبحث من خلالها المبدع المسرحي عن متلقي بديل عن الذي فقده ؟ .
Characterization of band alignment at a metal–MoS2 interface by Kelvin probe force microscopy
Authors: Okada Mitsuhiro , Okigawa Yuki , Fujii Takeshi , Endo Takahiko , Chang Wen Hsin , Okada Naoya , Irisawa Toshifumi , Miyata Yasumitsu , Shimizu Tetsuo , Kubo Toshitaka , Yamada Takatoshi 
Published: September 2023

Abstract
Transition metal dichalcogenides, such as MoS2, have garnered considerable attention because of their significant potential in device applications. A limiting factor in their development is the formation of a Schottky barrier with strong Fermi-level pinning at the metal–MoS2 interface. Herein, we report Kelvin probe force microscopy (KPFM) measurements of the work function (WF) modulation at this interface. We found an increase in the WF at the metal–MoS2 interface, depending on the layer number and the contact metal used, indicating the formation of a Schottky barrier. These variations potentially arise from the layer-number-dependent strength of Fermi-level pinning in MoS2. Visualization and calculation of WF modulation at metal–MoS2 interfaces using the KPFM method can help understand the structure and properties of such interfaces.
Fabrication of ZnO-encapsulated porous alumina structure utilizing a two-step anodizing technique for memristor applications
Authors: Yamamoto Myo Than Htay , Ishihara Yoshito , Hashimoto Yoshio 
Published: September 2023

Abstract
Highly ordered porous alumina thin films with various aspect ratios were fabricated by a two-step anodizing technique. The dependence of the high resistance state to low resistance state ratio on the aspect ratio of the pores was observed in the memristors utilizing porous alumina. The reduction of threshold voltage and improvement in stability were achieved by properly encapsulating i-ZnO inside the porous alumina as the switching medium. A significant improvement in the ratio of high resistance state to low resistance state was achieved by i-ZnO encapsulation in porous alumina compared to the conventional planer switching layer of ZnO alone.
A numerical study on delafossite CuFeO2 as an absorber for efficient and sustainable oxide solar cells
Authors: Sarkar D. K. , Mottakin M. , Hasan A. K. Mahmud , Selvanathan Vidhya , Ariful Islam Md. , Shahiduzzaman Md. , Alharbi Hamad F. , Akhtaruzzaman Md. 
Published: September 2023

Abstract
This study proposes an oxide solar cell in an n-p-p structure. This design uses a p-type delafossite CuFeO2 layer to absorb Sunlight, along with n-ZnO to transport electrons and p-NiO to transport holes. The SCAPS-1D modeling software was employed to conduct the relative study on the p-CuFeO2 absorber layer. The optimized thickness, bandgap, and bulk defects tolerance limit of the absorber layer are 700 nm, 1.3 eV, and 1014 cm─3, respectively. The charge carrier’s density in the absorber layer at 1018 cm─3 showed the highest performance. The defects tolerance limit of the interface n-ZnO/CuFeO2 is 1017 cm─3. After optimizing the device FTO/n-ZnO/CuFeO2/p-NiO/Au exhibited a maximum power conversion efficiency of 19.93%, corresponding V
oc of 1.10 V, J
sc of 24.95 mA cm−2, and FF of 85.5%. Additionally, this study demonstrates the prospect of CuFeO2 as the active layer in oxide-based solar cell technology.
PENGARUH KEBIJAKAN PIMPINAN DAN INTEGRITAS TERHADAP KOMPETENSI DAN KINERJA PELAKU PENGADAAN DALAM LINGKUP UKPBJ KABUPATEN HULU SUNGAI SELATAN
Authors: Bofrizewear Doddy 
Published: September 2023

Tujuan penelitian adalah untuk mengetahui dan menganalisa pengaruh kebijakan pimpinan terhadap kompetensi, integritas terhadap kompetensi, kebijakan pimpinan terhadap kinerja, integritas terhadap kinerja, kompetensi terhadap kinerja, kebijakan pimpinan secara tidak langsung terhadap kinerja melalui kompetensi dan integritas secara tidak langsung terhadap kinerja melalui kompetensi Pelaku Pengadaan Barang/jasa di lingkup UKPBJ Kab Hulu Sungai Selatan. Hasil penelitian menunjukkan bahwa kebijakan pimpinan tidak memiliki pengaruh nyata secara langsung terhadap kompetensi dan kinerja. Tetapi integritas memiliki pengaruh nyata secara langsung terhadap kompetensi dan kinerja. Kompetensi diketahui tidak memiliki pengaruh nyata secara langsung terhadap kinerja. Sementara kebijakan pimpinan dan integritas tidak memiliki pengaruh secara tidak langsung yang dimediasi oleh kompetensi.
Kata Kunci : kebijakan pimpinan, integritas, kompetensi dan kinerja
The Occurrence of Stunting during The COVID-19 Pandemic at Integrated Health Center: An Observational Study in Mekarjaya, Depok, West Java
Authors: Putri Salsabila Auni , Maskunah Maskunah , Riyanti Riyanti , Mulianingtyas Grace Valentina , Suhendra Faiza Assyifa , Octavia Lestari 
Published: September 2023

Pandemi COVID-19 dapat meningkatkan tantangan pemenuhan zat gizi, terutama untuk kelompok balita di negara dengan kondisi karakteristik dengan pendapatan rendah-mencegah termasuk Indonesia. Gangguan infeksi pada anak-anak, termasuk balita dapat diperburuk oleh kejadian malnutrisi dan berkontribusi pada kemungkinan transmisi virus SARS-CoV-2.
Posyandu menjadi ujung tombak dalam program pemantauan status gizi balita, termasuk di masa pandemi. Pada penelitian ini bertujuan untuk mengidentifikasi status gizi pada balita saat pandemi covid-19 di Pos Pelayanan Terpadu (Posyandu) “Kuntum Mekar A RW 21” di Mekarjaya, Kota Depok, Jawa Barat. Metode penelitian ini menggunakan data sekunder dari kegiatan penimbangan balita yakni: tinggi/panjang badan, jenis kelamin, dan usia. Hasil penelitian dengan total jumlah subjek 135 balita yang data hasil pengukurannya dapat diolah. Subyek terdiri dari 1 bayi baru lahir (0-3 bulan) yang tidak mengalami kategori stunting, 27 anak (4-12 bulan) dengan persentase stunting 7,4% dan stunting parah 3,7%, 31 balita (usia 13-23 bulan) dengan persentase stunting 12,9% dan stunting parah 3,2%. Dua puluh tujuh anak usia (24-35 bulan) persentase stunting 14,8%, 22 anak usia (36-47 bulan) persentase stunting 22,7% dan stunting parah 4,5%, dan untuk kelompok umur 47-59 bulan, 27 anak, persentase stunting 14,8%. Total prevalensi stunting di wilayah kerja Posyandu Kuntum Mekar A RW 21 Mekarjaya, Depok adalah 16,3%. Pendekatan penanganan stunting memerlukan kerjasama multisektor dan berkelanjutan untuk menciptakan generasi emas tahun 2045.