bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Innovative Model of ISS‐Based Multiple Fractures and Gastrointestinal Dysfunction Related to c‐Kit Protein Expression on Interstitial Cells of Cajal
Authors: Meng Shi‐Jie , Fan Meng‐Qiang , Qian Jian‐Sheng , Zhang Jing‐Wen , Xu Hui‐Hui , Zheng Yang , Zhao Wei‐Qiang , Shan Le‐Tian , Huang Jie‐Feng 
Published: March 2023

ObjectiveGastrointestinal dysfunction seriously affects the prognosis and quality of life of patients with multiple fractures. However, experimental evidence of this relationship is lacking. Here we describe a newly developed mouse model of postoperative gastrointestinal dysfunction after multiple fractures.MethodsTrauma severity was assessed using the injury severity score (ISS). Based on the ISS, a multiple fracture model was established in mice as follows: limb fractures with pelvic fractures and multiple rib fractures; limb fractures with multiple rib fractures; closed fracture of both forelegs with pelvic fracture and rib fractures; closed limb fractures; limb fracture with pelvic fracture; spinal fractures; hind leg fractures with pelvic fractures; pelvic fracture with multiple rib fractures; closed fracture of both fore legs with pelvic fracture; and closed fracture of both fore legs with multiple rib fractures. In each model group, gastrointestinal motility was assayed and the histopathology of the small intestine was examined. Western blot and immunohistochemical analyses of jejunal tissue were performed to detect c‐kit protein expression, the level of which was compared with that of a control group. The results of ANOVA are expressed as mean ± standard deviation.ResultsIn mice with multiple fractures, food intake was greatly reduced, consistent with histopathological evidence of an injured intestinal epithelium. The jejunal tissue of mice in groups a, c, f, and h was characterized by extensively necrotic and exfoliated intestinal mucosal epithelium and inflammatory cell infiltration in the lamina propria. In the gastrointestinal function assay, gastrointestinal motility was significantly reduced in groups a, b, c, f, and g; these group also had a higher ISS (p < 0.01). The expression of c‐kit protein in groups with gastrointestinal dysfunction was significantly up‐regulated (p < 0.001) compared with the control group. The close correlation between c‐kit expression and the ISS indicated an influence of trauma severity on gastrointestinal motility.ConclusionGastrointestinal dysfunction after multiple fractures was successfully reproduced in a mouse model. In these mice, c‐kit expression correlated with gastrointestinal tissue dysfunction and might serve as a therapeutic target.
Interventional pathway in the management of refractory chronic flank pain: Prospective series in 45 patients
Authors: Niraj G. 
Published: March 2023

AbstractBackgroundChronic flank pain can pose a therapeutic challenge. Current management centres on visceral pathology affecting the renal system. Acute exacerbations can be severe, requiring emergency admission. Patients usually have well‐established visceral pathology including polycystic kidney disease, Fowler's syndrome, and renal calculi disease that often cause recurrent urinary tract infections. However, in many cases, despite negative investigations including imaging, biochemistry and urine analysis, flank pain persists. Abdominal myofascial pain syndrome is a poorly recognized pathology in this cohort. The report describes the underlying pathophysiology and a novel interventional management pathway for patients presenting with refractory flank pain secondary to abdominal myofascial pain syndrome.MethodsAdult patients with refractory chronic flank pain at a tertiary renal unit were included as a part of an on‐going prospective longitudinal audit. Patients refractory to standard management were offered the interventional pathway. The pathway included two interventions: quadratus lumborum block with steroid and pulsed radio frequency treatment. Patients completed brief pain inventory and hospital anxiety and depression scale questionnaires at baseline, 3 and 6 months postprocedure. Outcomes collected included ability to maintain employment, change in opioid consumption at 6 months and impact on emergency hospital admissions at 12 months after initiation of the pathway.ResultsForty‐five patients were referred to the pain medicine clinic over a seven‐year period between 2014 and 2021. All patients were offered the interventions. Four patients refused due to needle phobia. Forty‐one patients received transmuscular quadratus lumborum plane block with steroids. Twenty‐seven patients (27/41, 66%) reported durable benefit at 6 months and six patients (6/41, 15%) had clinically significant relief at 3 months. Fifteen patients received pulsed radiofrequency to quadratus lumborum plane and 11 patients (73%) reported > 50% analgesia at 6 months. Treatment failure rate was 10% (4/41). Opioid consumption at 6 months and emergency admission at 12 months were reduced post intervention.ConclusionAbdominal myofascial pain syndrome is a poorly recognized cause of chronic flank pain syndrome. The interventional management pathway could be an effective solution in this cohort.
Spotting a potential threat: Measles among pediatric solid organ transplantation recipients
Authors: Statler Victoria A. , Fox Thomas , Ardura Monica I. 
Published: March 2023

AbstractBackgroundLow‐vaccination rates worldwide have led to the re‐emergence of vaccine‐preventable infections, including measles. Immunocompromised patients, including pediatric solid organ transplant (SOT) recipients, are at risk for measles because of suboptimal vaccination, reduced or waning vaccine immunity, lifelong immunosuppression, and global re‐emergence of measles.ObjectivesTo review published cases of measles in pediatric SOT recipients to heighten awareness of its clinical manifestations, summarize diagnostic and treatment strategies, and identify opportunities to optimize prevention.MethodsWe conducted a literature review of published natural measles infections in SOT recipients ≤21 years of age, summarizing management and outcomes. We describe measles epidemiology, recommended diagnostics, treatment, and highlight prevention strategies.ResultsThere are seven published reports of measles infection in 12 pediatric SOT recipients, the majority of whom were unvaccinated or incompletely vaccinated. Subjects had atypical or severe clinical presentations, including lack of rash and complications, most frequently with encephalitis and pneumonitis, resulting in 33% mortality. Updated recommendations on testing and vaccination are provided. Treatment options beyond supportive care and vitamin A are limited, with no approved antivirals.ConclusionWhile measles is infrequently reported in pediatric SOT recipients, morbidity and mortality remain significant. A high index of suspicion is warranted in susceptible SOT recipients with clinically compatible illness or exposure. Providers must recognize this risk, educate families, and be aware of both classic and atypical presentations of measles to rapidly identify, isolate, and diagnose measles in pediatric SOT recipients. Continued efforts to optimize measles vaccination both pre‐ and post‐SOT are warranted.
Evaluation of height centile growth patterns compared with parental‐adjusted target height following kidney transplantation
Authors: Ng Natasha Su Lynn , Gajendran Sellathurai , Plant Nicholas , Shenoy Mohan 
Published: March 2023

AbstractBackgroundEarly steroid withdrawal (ESW) improves growth following kidney transplant (KT). It is not known whether these children achieve target height within mid‐parental height range post‐KT.MethodsRetrospective analysis of growth patterns of KT recipients following ESW in our center between 2009 and 2020 had minimum follow‐up period of 12 months.ResultsForty‐eight (female 29.2%) KT recipients, median age 5.3 years at first KT, were included. At KT, 29 (60.4%) recipients had normal height (SDS≥‐1.88) and in 23 (47.9%), the height was within their target height (parental‐adjusted height SDS within ±1.55). The proportion of children achieving normal height at 1‐, 2‐, 3‐, and 5‐years post‐KT (median 5.5 years) were 75%, 83.3%, 86.5%, and 88% respectively. The proportion of children achieving target height measured at the same intervals was 68.8%, 73.8%, 73%, and 80%, respectively. Children <6 years were most growth impaired at KT but were most likely to achieve target height within first‐year post‐KT (72%; p = .023). All 19 children with short stature at KT received dialysis. Three children received growth hormone post‐KT. Children who did not achieve target height post‐KT (n = 14), five had eGFR <60 mL/min/1.73 m2, and eight were on corticosteroid therapy at latest follow‐up.ConclusionsAlthough vast majority of children achieved normal height post‐KT following ESW during the first 5 years post‐KT, 20% of these children had not achieved their target height post‐KT.
Anti‐thymocyte globulin induction with delayed introduction of tacrolimus preserves renal function in pediatric liver transplant recipients
Authors: Rogers Michael E. , Ambrosino Teresa , Hatcher Laura , Bondoc Alex , Tiao Greg , Peters Anna L. 
Published: March 2023

AbstractBackgroundTacrolimus (TAC)‐mediated renal disease occurs in up to 70% of pediatric liver transplant (LT) recipients. The safety and efficacy of renal‐sparing immunosuppression using anti‐thymocyte globulin (ATG) induction and delayed TAC administration has not been studied in children. We evaluated the safety and efficacy of ATG induction on preserving renal function in children within the first year (Y1) post‐LT in a single‐center retrospective cohort study.MethodsChildren under age 18 years of who received isolated LT from 2008 to 2020 with a GFR < 70 received renal‐sparing (RS) protocol consisting of ATG with methylprednisolone (MP), delayed TAC administration, lower initial TAC trough goals, and mycophenolate mofetil (MMF). The RS group was matched 1:2 by age and LT indication with standard immunosuppression (SI) group. Changes in renal function as well as adverse events within Y1 post‐LT were compared.ResultsForty‐four pediatric patients were included in the analysis, of which 13 received RS. As expected, the RS group had significantly lower mean TAC trough levels at 30 days (10.3 vs. 13.2, p = .001) post‐LT. Renal function was significantly preserved at 6 (−0.26 vs. 0.21, p = .004) and 12 months (−0.33 vs. 0.11, p = .003) post‐LT in the RS versus SI group as measured by mean change in serum creatinine, with similar trends observed in eGFR and cystatin C. ACR, sepsis, viremia, graft loss and mortality occurred at similar rates in both RS and SI groups.ConclusionInduction immunosuppression with ATG and delayed TAC administration in children with renal impairment is safe and effectively preserves renal function during Y1 post‐LT.
Insect lipid in fish nutrition: Recent knowledge and future application in aquaculture
Authors: Hossain Md. Sakhawat , Small Brian C. , Hardy Ronald 
Published: March 2023

AbstractInsect lipid/oil is a by‐product of insect meal production. The quantity and nutritional quality of insect lipid varies with species, life stages, the kind of substrate used to raise the insects, as well as the extraction process. Insect lipid products have been successfully used in animal feeds as source of nutrients, notably energy and indispensable fatty acids. Further some insect lipid products are potential functional ingredients in feed formulations because of the existence of some functional compounds, for example, lauric acid and monolaurin in black solder fly larvae oil (BSFLO). To date, research on the effects of insect product inclusion in aquafeed mainly focused on insect meal as protein source rather than insect oil/lipid as a lipid source. Research to date indicates that insect lipids can replace traditional energy sources in fish nutrition without negatively affecting fish growth and feed utilization performance. By raising the amount of long‐chain polyunsaturated fatty acids in fish fillets, insect lipids can improve fillet quality. Insect lipids may also positively influence general health of fish by stimulating the immune system and manipulating the gut microbiota. As there is a crucial need for searching alternate lipid sources in aquafeed to extend limited global supplies of fish oil and due to the insect lipids content and its fatty acid quality, there is a pressing need to expand experimentation concerning their application in aquafeed to support sustainable growth of the aquaculture industry.
Contribution of veterans' initial post‐separation vocational, financial, and social experiences to their suicidal ideation trajectories following military service
Authors: Hoffmire Claire A. , Borowski Shelby , Vogt Dawne 
Published: March 2023

AbstractBackgroundVeterans' success with navigating the challenges of transition from military service may contribute to their risk for suicidal outcomes. The concept of well‐being can help to conceptualize and assess successful navigation of reintegration challenges and may serve as an optimal target for public health‐oriented suicide prevention.MethodsThe relationship between US veterans' psychosocial well‐being and experiences of suicidal ideation (SI) during the first 3 years following military separation was evaluated using multinomial logistic regression predicting SI trajectories over time in a population‐based, longitudinal, post‐9/11 veteran cohort. At 3‐months post‐separation, veterans reported on their socio‐material conditions, functioning, and satisfaction with respect to vocational, financial, and social domains. SI frequency was assessed at 3‐, 9‐, 15‐, 21‐, and 27‐months post‐separation using the Patient Health Questionnaire‐9.ResultsVeterans' vocational, financial, and social well‐being were associated with their SI trajectories, even after accounting for mental health. Socio‐material conditions, functioning, and satisfaction all emerged as important predictors of SI trajectories, although results varied across domains. Effects were largest for social well‐being.ConclusionsSuicide prevention efforts may benefit from a holistic approach that considers veterans' needs for support across their vocational, financial, and social well‐being, inclusive of their socio‐material conditions, functioning, and satisfaction within each domain.
Choosing GIS graduate programs from afar: Chinese students' perspectives
Authors: Wang Yikang , Kang Yuhao , Liu Haokun , Hou Ce , Zhou Bing , Ye Shan , Liu Yuyan , Rao Jinmeng , Pei Zhenghao , Ye Xiang , Gao Song 
Published: March 2023

AbstractWith the increasing demands for geospatial analytics in industry and academia, the need for Geographic Information Systems/Science (GIS) education is on the rise. A growing number of departments in geography have launched or expanded their GIS graduate programs. However, the factors influencing students choosing GIS programs have not been examined yet. In this study, we looked at Chinese students applying for overseas GIS programs and examined factors influencing their decision‐making. We distributed the survey in GISphere, one of the largest GIS international student communities, and 84 valid questionnaires were returned. We analyzed the spatial and demographic patterns of Chinese students applying for overseas GIS programs. We identify five main factors that affect their choices of GIS programs: (1) education quality and awareness, (2) physical, social, and political environments, (3) improved employment prospects, (4) personal recommendations, and (5) the application process. Our study offers implications for the development of GIS graduate programs. We anticipate that the conclusions drawn from this research will benefit and advance geography and GIS education globally.
Rotated odometers
Authors: Bruin Henk , Lukina Olga 
Published: March 2023

AbstractWe describe the infinite interval exchange transformations, called the rotated odometers, which are obtained as compositions of finite interval exchange transformations and the von Neumann–Kakutani map. We show that with respect to Lebesgue measure on the unit interval, every such transformation is measurably isomorphic to the first return map of a rational parallel flow on a translation surface of finite area with infinite genus and a finite number of ends. We describe the dynamics of rotated odometers by means of Bratteli–Vershik systems, derive several of their topological and ergodic properties, and investigate in detail a range of specific examples of rotated odometers.
Catastrophic craton destruction via wholesale lithosphere delamination
Authors: Chen Hao , Tang Ming , Song Shuguang 
Published: March 2023

Abstract
The nuclei of continents, manifested as cratons, are the most long-lived parts of Earth’s lithosphere. However, ancient cratons in some areas can be substantially destroyed through mechanisms that are not fully understood. We used experimentally calibrated geobarometers to calculate the equilibrium pressures of mafic magmas in the North China craton, which directly constrain the evolving depth of the lithosphere-asthenosphere boundary beneath the craton through time. We show that the lithospheric thickness of the eastern part of the craton decreased from ~200 km to ~35 km in the Early Cretaceous. This intense destruction took place within a short time interval of ~10 m.y., at least locally. Following this destruction, the lithosphere gradually rethickened and stabilized as the upwelling asthenosphere cooled and formed a juvenile lithosphere. We suggest that this catastrophic lithosphere thinning resulted from wholesale lithosphere delamination. As a consequence of this catastrophic loss of thick mantle roots, the eastern part of the North China craton may have undergone rapid crustal rebound and surface uplift, as recorded by the regional unconformities formed between 130 and 120 Ma in the destructed area.
Cognitive impairment after cancer treatment: mechanisms, clinical characterization, and management
Authors: Fleming Ben , Edison Paul , Kenny Laura 
Published: March 2023

Abstract
Cognitive impairment is a debilitating side effect experienced by patients with cancer treated with systemically administered anticancer therapies. With around 19.3 million new cases of cancer worldwide in 2020 and the five year survival rate growing from 50% in 1970 to 67% in 2013, an urgent need exists to understand enduring side effects with severe implications for quality of life. Whereas cognitive impairment associated with chemotherapy is recognized in patients with breast cancer, researchers have started to identify cognitive impairment associated with other treatments such as immune, endocrine, and targeted therapies only recently. The underlying mechanisms are diverse and therapy specific, so further evaluation is needed to develop effective therapeutic interventions. Drug and non-drug management strategies are emerging that target mechanistic pathways or the cognitive deficits themselves, but they need to be rigorously evaluated. Clinically, consistent use of objective diagnostic tools is necessary for accurate diagnosis and clinical characterization of cognitive impairment in patients treated with anticancer therapies. This should be supplemented with clinical guidelines that could be implemented in daily practice. This review summarizes the recent advances in the mechanisms, clinical characterization, and novel management strategies of cognitive impairment associated with treatment of non-central nervous system cancers.
Mpox (monkeypox) information on TikTok: analysis of quality and audience engagement
Authors: Shi Ao , El Haddad Joe , Cai Peng , Song Shijie , Wang Yuan Jia , Liu Qi , Li Pengyang 
Published: March 2023

BackgroundOnline information on mpox (monkeypox) is not well studied. We have analysed the video content, information quality, and audience engagement of mpox-related videos on TikTok.MethodsUsing a hashtag-based searching strategy, we identified 2462 mpox-related videos on TikTok from 1 January to 11 August 2022; 85 were included after exclusion criteria screening. Videos were evaluated for content on features and treatment of mpox. Video and information quality was assessed using the DISCERN instrument and theJournal of the American Medical Association(JAMA) criteria. We recorded video source, evaluation scores, and viewer engagement metrics. The Kruskal-Wallis test was used for statistical analysis and multiple linear regression for factor-association studies.ResultsOf the 85 videos, two assessed all content topics and highlighted 33% of all content items in clinical guidelines. The overall average score for the videos was 39.56 of 80 on the DISCERN instrument and 1.93 of 4 on the JAMA criteria. No video met all JAMA criteria. Subgroup analysis based on author identity suggested the variance in video scores by source (p<0.05 for all). Overall scores were higher for videos produced by doctors and science communicators than for those made by institutional users, nurses, and the general public. Multiple linear regression analysis showed that having people in the video (69.20, p=0.0001) and including information on treatment choices (1.15, p=0.045) were significant, independent determinants of audience engagement.ConclusionPublic-directed TikTok videos on mpox frequently provide incomplete, inaccurate information, highlighting the potential risks of using TikTok as a health information source.
Women, their Offspring and iMproving lifestyle for Better cardiovascular health of both (WOMB project): a protocol of the follow-up of a multicentre randomised controlled trial
Authors: van de Beek Cornelieke , Hoek Annemieke , Painter Rebecca C , Gemke Reinoud J B J , van Poppel Mireille N M , Geelen Anouk , Groen Henk , Willem Mol Ben , Roseboom Tessa J 
Published: March 2023

IntroductionWomen, their Offspring and iMproving lifestyle for Better cardiovascular health of both (WOMB) project is the follow-up of the LIFEstyle study, a randomised controlled trial in obese infertile women, and investigates the effects of a preconception lifestyle intervention on later health of women (WOMB women) and their children (WOMB kids).Methods and analysisObese infertile women, aged between 18 and 39 years, were recruited in 23 Dutch fertility clinics between June 2009 and June 2012. The 284 women allocated to the intervention group received a 6-month structured lifestyle programme. The 280 women in the control group received infertility care as usual. 4 to 7 years after inclusion in the trial, all women (n=564) and children conceived during the trial (24 months after randomisation) (n=305 singletons and age 3–5 years) will be approached to participate in this follow-up study (starting in 2015). The main focus of outcome will be cardiovascular health, but the dataset comprises a wide range of physical and mental health measures, diet and physical activity measures, child growth and development measures, biological samples and genetic and epigenetic information. The follow-up assessment consists of three stages that take place between 2016 and 2018, and includes (online) questionnaires, accelerometry and physical and behavioural measurements in a mobile research vehicle. A subsample of 100 women and 100 children are planned for cardiac ultrasound measurements.Ethics and disseminationThe protocol of this follow-up study is approved by the local medical ethics committee (University Medical Centre Groningen). Study findings of the WOMB project will be widely disseminated to the scientific community, healthcare professionals, policy makers, future parents and general public.Trial registration numberThe original LIFEstyle study is registered at The Netherlands Trial Registry (number 1530).