bluuebunny/crossref_metadata_2025_split huggingface dataset:
Emerging Trends on the Correlation Between Diabetes and Oxidative Stress from 2003 to 2022: A Bibliometric Analysis
Authors: Zhang Yu , Zhou Guozhong , Zhou Yuanyuan , Tu Yungui , Shi Wei , Shi Weili , Long Rong , Kong Defu , Yang Feifei , Chen Nan 
Published: March 2023

Abstract
Background: Diabetes mellitus (DM) and its complications pose serious threats to global public health. As diabetes is a systemic metabolic disease, various studies have shown that it is associated with oxidative stress. Therefore, studies linking diabetes and oxidative stress have received considerable attention. However, no previous studies have analysed the relationship between diabetes and oxidative stress through a bibliometric approach. To fill this knowledge gap and summarise the research hotspots and trends, we conducted a comprehensive bibliometric analysis of global scientific publications in this field.
Methods: We extracted all relevant English-language publications on diabetes and oxidative stress from the Web of Science between 1 January 2003 and 31 October 2022. CiteSpace V 5.8.R3, VOSviewer 1.6.16, and two online analysis platforms were used for bibliometric and visual analyses.
Results: A total of 44291 articles were identified, including 33,710 articles, 9473 reviews, and 1108 meeting abstracts. The number of publications has increased gradually over the past 20 years. China and the United States are the largest contributors to publications in this field. China Med University is the institution with most publications, and LU CAI is the author with the most publications. There is relatively little collaboration among institutions in different countries. The journal that published the most papers related to diabetes and oxidative stress is the International Journal of Molecular Sciences. According to co-cited references result, ‘bioactive compounds’, ‘SGLT2 inhibitors’, ‘diabetic cardiomyopathy’, and ‘diabetic retinopathy’ are the main research hotspots. Based on the results of the topic evolution, ‘risk’, ‘expression’, ‘oxidative stress’, and ‘antioxidant activity’ are focal points of current research.
Conclusion: This study provides a systematic and objective view of the field, which helps readers evaluate the characteristics of publications involving diabetes and oxidative stress and helps researchers formulate rational research protocols.
Novel Methods to Measure the Quality of 2D Images Compression Techniques
Authors: Rasheed Mohammed H. , Fadhel Hussein Nadhem , Siddeq Mohammed M. 
Published: March 2023

Abstract

It is essential to use image quality measuring metrics tools that can provide accurate and close to perceived quality sense of the tested images. Such tools give metrics that can be used to compare the performance of compression algorithms. In this paper, two new metrics to measure the quality of decompressed images are proposed. Compared with other metrics e.g. peak signal to noise ratio (PSNR) and root mean square error (RMSE), the proposed metrics give values with the closest reflection of image quality perception by the human eye.
Perilipin5 protects against non-alcoholic steatohepatitis by increasing 11-Dodecenoic acid and inhibiting the occurrence of ferroptosis
Authors: Xu Xinming , Qiu Jin , Li Xiaoya , Chen Juntong , Li Yue , Huang Xinmei , Zang Shufei , Ma Xinran , Liu Jun 
Published: March 2023

Abstract
Background
Non-alcoholic steatohepatitis (NASH) is a major contributor to liver cirrhosis and hepatocellular carcinoma (HCC). There remains no effective pharmacological therapy. The hepatic lipid metabolism and fatty acid β-oxidation are regulated by Perilipin5 (Plin5). However, it is yet unknown how Plin5 affects NASH and the molecular process.
Methods
High-fat, high-cholesterol and high-fructose (HFHC) diets were used to mimic the progression of NASH in wild type (WT) mice and Plin5 knockout (Plin5 KO) mice. The degree of ferroptosis was measured by detecting the expression of key genes of ferroptosis and the level of lipid peroxide. The degree of NASH was judged by observing the morphology of the liver, detecting the expression of inflammation and fibrosis related genes of liver damage. Plin5 was overexpressed in the liver of mice by tail vein injection of adenovirus, and the process of NASH was simulated by methionine choline deficiency (MCD) diet. The occurrence of ferroptosis and NASH was detected by the same detection method. Targeted lipidomics sequencing was used to detect the difference in free fatty acid expression in the WT Plin5 KO group. Finally, it was verified in cell experiments to further study the effect of free fatty acids on ferroptosis of hepatocytes.
Results
In various NASH models, hepatic Plin5 was dramatically reduced. Plin5 knockout (KO) worsened NASH-associated characteristics in mice given a high-fat/high-cholesterol (HFHC) diet, such as lipid accumulation, inflammation and hepatic fibrosis. It has been shown that ferroptosis is involved in NASH progression. We revealed that Plin5 KO in mice aggravated the degree of ferroptosis in NASH models. Conversely, overexpression of Plin5 significantly alleviated ferroptosis and further ameliorated progression of MCD-induced NASH. Analysis of livers obtained from HFHC diet-fed mice by targeted lipidomics revealed that 11-Dodecenoic acid was significantly decreased in Plin5 KO mice. Addition of 11-Dodecenoia acid to Plin5 knockdown hepatocytes effectively prevented ferroptosis.
Conclusion
Our study demonstrates that Plin5 protects against NASH progression by increasing 11-Dodecenoic acid level and further inhibiting ferroptosis, suggesting that Plin5 has therapeutic potential as a target for the management of NASH.
Intractable chylous leak after radical esophagectomy treated with radiotherapy
Authors: Ahn Seha , Lee Heejin , Kang Joon Kyu , Kim In Sub , Moon Youngkyu , Choi Jung Suk , Jeong Seong Cheol , Choi Si Young 
Published: March 2023

Abstract
Postoperative chylous leak after esophagectomy is a rare but potentially life-threatening complication that results in hypovolemia, electrolyte imbalance, malnutrition, and immunologic deficiency. However, the management of postoperative chylous leak remains controversial. Following a diagnosis of esophageal cancer, a 64-year-old man was treated by video-assisted thoracoscopic esophagectomy, laparoscopic gastric tube formation, prophylactically thoracic duct ligation, and reconstruction with esophagogastrostomy at the neck level. Massive postoperative drainage from the thorax and abdomen did not initially meet the diagnostic criteria for chylothorax, which was ultimately diagnosed 3 weeks after the operation. Despite various treatments including total parenteral nutrition, octreotide and midodrine, reoperation (thoracic duct ligation and mechanical pleurodesis), and thoracic duct embolization, the chylous leak persisted. Finally, low-dose radiation therapy was administered with a daily dose of 2 Gy and completed at a total dose of 14 Gy. After this, the amount of pleural effusion gradually decreased over 2 weeks, and the last drainage tube was removed. The patient was alive and well at 60 months postoperatively. Herein, we describe a patient with intractable chylous leak after esophagectomy, which persisted despite conservative treatment, thoracic duct ligation, and embolization, but was finally successfully treated with radiotherapy.
Analysis of Repeaters in Fiber Optic Communication
Authors: S Sabapathi.T , Student Rakshana.C 
Published: March 2023

Abstract
An Optical Repeater is used in a fiber optic communications system to regenerate the input optical signal and they are used to transmit a long distance by overcoming loss due to the attenuation of the optical fiber. Repeaters are used to boost incoming signals in the fiber. Optical Spectrum at different links in a fiber optic link is being observed. For some conditions, the output spectrum of an EDFA/OA would be distorted this has to be analyzed for various settings of OA so that optimum transmitted power, optimum repeater spacing, and optimum individual repeaters parameters are to be found out which will make the WDM spectrum with uniform gain for all wavelengths. The main objective is to increase the spacing between the repeaters and hence reduce the number of repeaters and find the optimum transmitting power and reduce the non-linearities such as Four Wave Mixing, Self-Phase Modulation, and Cross-Phase Modulation
Associations between Probiotic Exposure and Hepatic Steatosis: A nationwide cross-sectional study
Authors: Song Yancheng , Guo Wencong , Wang Junke , Liu Shuguang , Li Zhaopeng , Li Zhao , Guo Dong , Li Yu 
Published: March 2023

Abstract
Background: Recent research showed that probiotics treatment may reduce insulin resistance, regulate lipid metabolism, raise liver enzyme levels, and ameliorate inflammation in individuals with non-alcoholic fatty liver disease (NAFLD). However, the association between probiotic use and hepatic steatosis in people has not been identified. The purpose of this study was to investigate the possible relationship between probiotic exposure and hepatic steatosis.
Methods: The cross-sectional research was conducted among adults with complete data on probiotic exposure and hepatic steatosis in the 2011-2016 National Health and Nutrition Examination Survey (NHANES). Probiotic exposure was assessed using a dietary supplement questionnaire. Hepatic steatosis was evaluated with hepatic steatosis index (HSI). Weighted multivariable regression analysis, subgroup analysis, and interaction analysis were conducted to explore the independent relationship between probiotic exposure and hepatic steatosis. The restricted cubic spline (RCS) was used to analyze the curve association between yogurt and hepatic steatosis.
Results：A total of 7891 participants were included in the study represented 146.7 million non-institutionalized residents of the United States, of whom 4322 (54.77%) were diagnosed with hepatic steatosis. Multivariable logistic regression showed probiotic exposure had significantly inverse associations for hepatic steatosis (OR = 0.84, 95% CI: 0.72–0.97, P=0.02) after adjusting for all covariates. Once more, the independent relationship between probiotic exposure and hepatic steatosis was verified by subgroup analysis and interaction analysis. The restricted cubic spline model demonstrated a robust J-shaped link between yogurt and hepatic steatosis, revealing a significant decrease in risk within the lower range of yogurt, which attained the lowest risk close to 0.4 cup.
Conclusions: These results suggested that probiotic exposure may have beneficial effects for hepatic steatosis, along with a J-shaped relationship between yogurt and hepatic steatosis. This study recommends that adults take half a cup of yogurt daily. Further research is required to identify the mechanistic relationships between probiotics exposure and hepatic steatosis.
Proteome profiling of hippocampus reveals the neuroprotective effect of mild hypothermia on global cerebral ischemia-reperfusion injury in rats
Authors: Wang Jiajia , Dai Yuting , Sun Xiaopeng , Ma Yuan , Wang Mingshan , Qin Weiwei 
Published: March 2023

Abstract
Background: Cerebral ischemic is one of the leading causes of disability and mortality worldwide. Blood reperfusion of ischemic cerebral tissue may cause cerebral ischemia-reperfusion (IR) injury.
Methods: In this study, a rat model of global cerebral I/R injury was established via Pulsinelli’s four-vessel occlusion (4-VO)method. The liquid chromatography-tandem mass spectrometry (LC-MS/MS)and bioinformatics analysis were employed to examine the ipsilateral hippocampus proteome profiles of rats with/without MH (32℃) treatment after IR injury.
Results: Totally 2 122 proteins were identified, among which 153 proteins were significantly changed associated with MH (n=7 per group, fold change-1.5, p < 0.05). GO annotation of the differentially expressed proteins (DEPs) revealed that cellular oxidant detoxification, response to zinc ion, aging, oxygen transport, negative regulation of catalytic activity, response to hypoxia, regulation of protein phosphorylation, and cellular response to vascular endothelial growth factor stimulus were significantly enriched with MH treatment. The KEGG analysis indicated that metabolic pathways, thermogenesis, pathways of neurodegeneration, chemical carcinogenesis - reactive oxygen species, fluid shear stress and atherosclerosis, and protein processing in endoplasmic reticulum were significantly enriched with MH treatment. Importantly, changes in 16 DEPs were reversed by MH treatment. Among them, VCAM-1, S100A8, CaMKK2 and MKK7 were verified as potential markers associated with MH neuroprotection by Western blot analysis.
Conclusions: This study is one of the first to investigate the neuroprotective effects of MH on the hippocampus proteome of experimental models of cerebral IR injury. These DEPs may be involved in the most fundamental molecular mechanisms of MH neuroprotection, and provide a scientific foundation for further promotion of reparative strategies in cerebral IR injury.
Transient intracranial pressure elevations are associated with sleep apnea
Authors: Riedel Casper Schwartz , Martinez-Tejada Isabel , Andresen Morten , Wilhjelm Jens E. , Jennum Poul , Juhler Marianne 
Published: March 2023

Abstract
Background
Repetitive transient intracranial pressure waveform elevations up to 50 mmHg (ICP B-waves) are often used to define pathological conditions and determine intracranial pressure-reducing treatment indications. We recently showed that nocturnal transient ICP elevations are present in patients without structural brain lesions or hydrocephalus in whom they are associated with sleep apnea. However, whether this signifies a general association between intracranial pressure patterns and sleep apnea is still unknown.
Methods
We included 34 patients with hydrocephalus, or idiopathic intracranial hypertension (IIH), referred to the Neurosurgical Department, Copenhagen, Denmark, from 2017 to 2021. Every patient underwent a diagnostic overnight intracranial pressure monitoring on clinical indications with simultaneous polysomnography (PSG) sleep studies. All transient ICP elevations were objectively quantified for all patients. Three patients were monitored with continuous positive airway pressure (CPAP) treatment for an additional night.
Results
All patients had transient intracranial pressure elevations associated with sleep apnea. The mean temporal delay from sleep apnea to transient intracranial pressure elevations for all patients was 3.6 seconds (SEM 0.2 seconds). High amplitude ramp-type transient intracranial pressure elevations were associated with rapid eye movement (REM) sleep and sinusoidal-type elevations with non-REM (NREM) sleep. CPAP treatment reduced the number of transient intracranial pressure elevations in all three patients (mean 37%). CPAP treatment elevated the mean intracranial pressure during sleep in two patients by 1.2 and 5.6 mmHg, respectively, and reduced the mean intracranial pressure in one patient with a ventriculoperitoneal shunt by 1.0 mmHg.
Conclusion
The findings suggest that sleep apnea causes a significant proportion of transient intracranial pressure elevations, and sleep apnea should be considered in intracranial pressure evaluation. Continuous positive airway pressure (CPAP) treatment can reduce their occurrence. However, CPAP may concurrently elevate the mean intracranial pressure. More research is needed on the impact of slow oscillating mechanisms on transient intracranial pressure elevations during high intracranial pressure and REM sleep.
Past attachment experiences, the potential link of mentalization and the transmission of behavior to the child by mothers with mental health problems: cross-sectional analysis of a clinical sample
Authors: Mattheß Janna , Koch Gabriele , Keil Thomas , Roll Stephanie , Berghöfer Anne , Ludwig-Körner Christiane , Schlensog-Schuster Franziska , Sprengeler Mona Katharina , von Klitzing Kai , Kuchinke Lars 
Published: March 2023

Abstract
Maternal capacity to mentalize (= reflective functioning, RF), secure attachment and emotional available parenting has an impact on the child’s development. The transmission of past attachment experiences of mother’s made with both her caregivers in her own childhood and the impact on current mother-child interaction is part of the ‘transmission gap’. This study explores the transgenerational transmission mechanisms and the potential moderating effect of RF in a clinical sample of 113 mother-child dyads suffering from mental health problems. In a cross-sectional study the associations between maternal attachment experiences, RF (coded based on Adult Attachment Interviews) and current mother-child interaction (Emotional Availability Scales) were examined with univariate correlation-, moderator analyses, and structural equation models. We found relationships between attachment experiences and mother-child interaction, but RF had no moderating effect. Past loving experiences and perceived neglection particularly with the own father in childhood were predictors for the present mother-child interaction. There seems to be an intergenerational transmission of attachment experiences to the ongoing generation. Particularly past adverse childhood experiences with the own father seem to explain currently disruptive interactions with the child.
Trial Registration IDs: DRKS00017008 & DRKS00016353
Cystic squamous metaplasia in a giant benign phyllodes tumor of the breast: A case report
Authors: Niyonkuru Evrard , Nisabwe Simon , Sami Zineb , Faizi Issam , Mazti Asmae , Elkarroumi Mohamed , Karkouri Mehdi 
Published: March 2023

Abstract
Background

Phyllodes tumor is rare tumor of the breast, which encompasses both stromal and epithelial components. In these components, metaplastic changes can be observed occasionally.

Case presentation

We report the case of a 51-year-old woman nulligest menopaused who presented a huge mass, largely ulcerated in her right breast. The radiological examination revealed a large tumor with microcalicifications classified as Breast Imaging and Reporting Data System [BI-RADS] category 5. The patient undergone right mastectomy and the histological analysis revealed benign phyllodes tumor with cystic squamous metaplasia.

Conclusions

It is essential to be aware of this uncommon event in order to avoid misdiagnosis.
MicroMagnify: a multiplexed expansion microscopy method for pathogens and infected tissues
Authors: Zhao Yongxin , Cheng Zhangyu , Stefani Caroline , Skillman Thomas , Klimas Aleksandra , Lee Aramchan , DiBernardo Emma , Brown Karina Mueller , Milman Tatyana , Gallagher Brendan , Lagree Katherine , Jena Bhanu , Pulido Jose , Filler Scott , Mitchell Aaron , Hiller Luisa , Lacy-Hulbert Adam 
Published: March 2023

Abstract
Super-resolution optical imaging tools are crucial in microbiology to understand the complex structures and behavior of microorganisms such as bacteria, fungi, and viruses. However, the capabilities of these tools, particularly when it comes to imaging pathogens and infected tissues, remain limited. We developed µMagnify, a nanoscale multiplexed imaging method for pathogens and infected tissues that are derived from an expansion microscopy technique with a universal biomolecular anchor. We formulated an enzyme cocktail specifically designed for robust cell wall digestion and expansion of microbial cells without distortion while efficiently retaining biomolecules suitable for high-plex fluorescence imaging with nanoscale precision. Additionally, we developed an associated virtual reality tool to facilitate the visualization and navigation of complex three-dimensional images generated by this method in an immersive environment allowing collaborative exploration among researchers around the world. µMagnify is a valuable imaging platform for studying how microbes interact with their host systems and enables development of new diagnosis strategies against infectious diseases.
A Monte Carlo Study on Skin Dose Contamination Coefficients of 252Cf Radionuclide
Authors: Malidarre Roya Boodaghi , Akkurt Iskender 
Published: March 2023

Abstract
Handling of 252Cf radionuclide source can lead to contamination of the skin surface in case of an accident. There is still an increasing demand to have dose conversion coefficients of each primary particle and different sources. On the other hand, there is no literature that presents actual values and methods for determining skin dose contamination and its coefficients for 252Cf source. Thus, this paper is concerned with quantifying the received dose rate and its coefficients in the skin as a result of a contamination scenario. The equivalent and absorbed dose rates, as well as SDCC, are estimated using MCNPX Monte-Carlo simulation’s well-established calculation code in the skin. Two methods i.e. watt fission and doppler effect are proposed for calculating particles’ spectra, and consequently, with the help of flux–to–dose conversion function Equivalent dose rates are derived. Also, the SDCC on the skin surface for different particles is obtained and these values are reported for 252Cf radionuclide. The particles of interest in this study are neutrons and gamma photons. The new dose coefficients allow the estimation of the skin dose contamination in radionuclides of interest.
Association of plasma iron with the risk of incident cancer in Chinese adults with hypertension: a nested case-control study
Authors: Zhu Hehao , Wei Yaping , He Qiangqiang , Song Yun , Liu Lishun , Zhou Ziyi , Li Jianping , Zhang Yan , Sun Yong , Zhang Hao , Guo Huiyuan , Xu Xiping , Wang Binyan 
Published: March 2023

Abstract
Background: Iron is an essential element for organismal health but excessive iron is potentially toxic. However, few observational studies link plasma iron (PI) concentrations and cancer risk, and the results are inconsistent.
Objective: This study aimed to explore the associations of PI concentrations with cancer risk in Chinese adults with hypertension.
Methods: We conducted a nested, case-control study, including 223 pairs of incident cancer cases and matched controls from the China Stroke Primary Prevention Trial. The median time between blood sample collection and subsequent cancer event occurrence was 2.13 years. Odds ratio (OR) and 95% confidence interval (CI) for the risk of cancer by PI were estimated from multivariable conditional logistic regression models.
Results: There was a J-shaped association between PI concentrations and total cancer risk. When compared with participants in tertile 2 of PI, the ORs of total cancer were 2.17 (95% CI: 1.25,3.85) and 1.29 (95% CI: 0.77,2.19) in participants in PI tertiles 3 and 1, respectively. Furthermore, higher PI was associated with increased digestive system cancer risk (OR=3.25, 95% CI=1.29,8.90), while lower PI was associated with increased risk of non-digestive system cancer (OR=3.32,95% CI=1.39,8.71). In a sensitivity analysis, the increases in total cancer risk or digestive system cancer risk were still observed with higher PI after excluding cancer cases occurring within the first year.
Conclusions: Our results showed an increased risk of cancer related to higher PI or lower PI in Chinese adults with hypertension. Higher iron levels were linked to increased risk of digestive system cancers, whereas lower iron levels were linked to increased risk of non-digestive system cancers.