bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Novel Photosynthetic Biohybrid System for Microenvironment Regulation of Diabetes Retinopathy through Continuous Oxygen Supply and Nanozyme Cascade Reaction
Authors: Zhou Liyang , Lan Kaiyue , Huang Xiaomin , Huang Yuyan , Jin Yingying , Lu Si , Guo Yishun , Su Lili , Peng Yaou , Deng Zhennv , Yang Jianhua , Qian Siyuan , Lou Wanqing , Chu Xiaoying , Guo Hanwen , Wang Bailiang 
Published: July 2023

AbstractAccording to International Diabetes Federation Diabetes Atlas statistics, diabetic retinopathy (DR) is the leading cause of vision loss in blinding diseases. The underlying cause of retinal vasculopathy progression in diabetic patients is hyperglycemia and hypoxia features in microvascular region. Hence, cyanobacteria are used as carriers to load both gold nanoparticles (Au NPs) with glucose oxidase‐like activity and iridium nanoparticles (Ir NPs) with catalase‐like activity, respectively (Cyano@Au@Ir). The Au NPs nanozyme first degrades glucose into hydrogen peroxide, which is further decomposed into H2O and O2 by the Ir NPs to complete the cascade hypoglycemic reaction. Based on the unique light transmittance of eyeball and the accumulation of light in the retinal area, the sustainable O2 production by Cyano greatly alleviates the hypoxia of microenvironment, leading to the decrease of angiogenic growth factor and hypoxia‐inducible factor expressions. Simultaneously, the highly expressed peroxide in the DR microenvironment can also be eliminated by Ir NPs for anti‐inflammatory property. Furthermore, it is demonstrated in DR animal model that Cyano@Au@Ir significantly reduces neovascular progression and vascular leakage. This novel treatment mode fundamentally degrades blood glucose, continuously supplies O2, and scavenges free radicals for comprehensive microenvironment regulation, providing inspirations for solving fundus complications of DR.
Air‐Processed Blue Perovskite Light‐Emitting Diodes Enabled by Manipulation of Adsorbed‐Moisture‐Dominated Crystallization Kinetics
Authors: Li Huixin , Wu Jiandong , Hu Siliang , Zhang Weiting , Gao Jialiang , Guo Yangyang , Guo Pengfei , Liu Chen , Zhao Guanguan , Fu Maosen , Bian Hongtao , Liu Taihong , Wang Hongyue , Wang Hongqiang 
Published: July 2023

AbstractThe fabrication of blue perovskite light‐emitting diodes (PeLEDs) in air conditions promises to liberate the manipulation procedures from the protection of inert atmosphere in the glovebox, which will remarkably promote the commercialization proceeding of perovskite‐based optoelectronic devices in display applications. However, achieving air‐processed blue PeLEDs in the interference of moisture meets great challenges in crystallization kinetics control. Herein, it is proposed that substrate‐adsorbed moisture dominates the perovskite crystallization kinetics during the fabrication in air, and the limited moisture from nonhygroscopic substrate inhibits the nucleation of the large‐n phase and allows the growth of the small‐n phase, thus yielding blue quasi‐2D perovskite films in a wide moisture range of 10–50% relative humidity. Then, air‐processed blue PeLEDs are successfully achieved for the first time, showing a brightness of 968 cd m−2, external quantum efficiency of 2.54% at stable peak emission of 483 nm, as well as an outstanding operating stability of 546 s at a peak brightness of 45 cd m−2, which are favorably competitive with PeLEDs fabricated in the glovebox. This work provides a guideline for air‐processed blue PeLEDs fabrication, which paves the way for air‐processed PeLEDs in further application of commercialization display.
Construction of Organic‐Rich Solid Electrolyte Interphase for Long‐Cycling Lithium–Sulfur Batteries
Authors: Li Zheng , Li Yuan , Bi Chen‐Xi , Zhang Qian‐Kui , Hou Li‐Peng , Li Xi‐Yao , Ma Jin , Zhang Xue‐Qiang , Li Bo‐Quan , Wen Rui , Zhang Qiang 
Published: July 2023

AbstractLithium–sulfur (Li–S) batteries promise great potential as high‐energy‐density energy storage devices. However, the parasitic reactions between lithium polysulfides (LiPSs) and Li metal anodes render limited cycling lifespan of Li–S batteries. Herein, an organic‐rich solid electrolyte interphase (SEI) is constructed to inhibit the LiPS parasitic reactions and achieve long‐cycling Li–S batteries. Concretely, 1,3,5‐trioxane is introduced as a reactive co‐solvent that decomposes on Li anode surfaces and contributes organic components to the SEI. The as‐constructed organic‐rich SEI effectively inhibits the LiPS parasitic reactions and protects working Li metal anodes. Consequently, the cycling lifespan of Li–S coin cells with 50 µm Li anodes and 4.0 mg cm−2 sulfur cathodes is prolonged from 130 to 300 cycles by the organic‐rich SEI. Furthermore, the organic‐rich SEI enables a 3.0 Ah‐level Li–S pouch cell to achieve a high energy density of 400 Wh kg−1 and stable 26 cycles. This study affords an effective organic‐rich SEI to inhibit the LiPS parasitic reactions and inspires rational SEI design to achieve long‐cycling Li–S batteries.
Directed Neural Stem Cells Differentiation via Signal Communication with Ni–Zn Micromotors
Authors: Feng Ye , Gao Chao , Xie Dazhi , Liu Lu , Chen Bin , Liu Suyi , Yang Haihong , Gao Zhan , Wilson Daniela A. , Tu Yingfeng , Peng Fei 
Published: July 2023

AbstractNeural stem cells (NSCs), with the capability of self‐renewal, differentiation, and environment modulation, are considered promising for stroke, brain injury therapy, and neuron regeneration. Activation of endogenous NSCs, is attracting increasing research enthusiasm, which avoids immune rejection and ethical issues of exogenous cell transplantation. Yet, how to induce directed growth and differentiation in situ remain a major challenge. In this study, a pure water‐driven Ni–Zn micromotor via a self‐established electric–chemical field is proposed. The micromotors can be magnetically guided and precisely approach target NSCs. Through the electric–chemical field, bioelectrical signal exchange and communication with endogenous NSCs are allowed, thus allowing for regulated proliferation and directed neuron differentiation in vivo. Therefore, the Ni–Zn micromotor provides a platform for controlling cell fate via a self‐established electrochemical field and targeted activation of endogenous NSCs.
Enhanced Ferroelectricity in Hf‐Based Ferroelectric Device with ZrO2 Regulating Layer
Authors: Liu Yongkai , Wang Tianyu , Li Zhenhai , Yu Jiajie , Meng Jialin , Xu Kangli , Liu Pei , Zhu Hao , Sun Qingqing , Zhang David Wei , Chen Lin 
Published: July 2023

AbstractHfAlO film‐based ferroelectric memory is a strong contender for the next‐generation nonvolatile memories. However, the remanent polarization intensity of HfAlO films is small compared to other Hf‐based ferroelectric films at low annealing temperatures. In order to further improve the remnant polarization of the device, the ferroelectric memory with metal‐ferroelectric‐metal structure using ZrO2 as the regulating layer (RL) is designed and fabricated. Experimental results show that the device with the ZrO2 regulating layer exhibits triple enhancement, which may be due to the fact that ZrO2 RL has an effect on the enhancement of the ferroelectric phase. In addition, the device with ZrO2 regulating layer exhibits a superior ON/OFF conductance ratio, endurance, and retention characteristics, demonstrating potential for application to memory. This work provides an effective way to improve the ferroelectricity in HfAlO films at low annealing temperatures.
Achieving Material and Energy Dual Circulations of Spent Lithium‐Ion Batteries via Triboelectric Nanogenerator
Authors: Zhang Baofeng , He Lixia , Zhang Ruolin , Yuan Wei , Wang Jing , Hu Yuexiao , Zhao Zhihao , Zhou Linglin , Wang Jie , Wang Zhong Lin 
Published: July 2023

AbstractThe electrification of transportation in the past few decades has sparked the retirement of lithium‐ion batteries (LIBs) which hinders sustainability derived from environmental impact and valuable elements loss through improper disposal. The challenges of recycling spent LIB are contamination, complicated processes, massive chemical/energy consumption, and secondary pollution. Here, a material and energy dual circulations method is proposed for a closed‐loop and sustainably recycling the components in spent LIBs. In the material circulation, the cathode, anode, and the accessories, like castings, aluminum‐plastic films, and binders, are recycled by electrochemical dual‐electrode recycling technology to regenerate LIBs and fabricate a triboelectric nanogenerator (TENG). In energy circulation, the fabricated TENG converts ambient wind energy into electricity to continuously power the material circulation by forming a self‐powered system. This system shows high element selectivity (Li, 99.7%; Ni, 96.1%; Co, 97.3%; and Mn, 97.2%), self‐powering, a simplified treating procedure, and high profit, which makes it feasible for commercial application.
Short‐term responses of soil carbon, nitrogen, and microbial biomass to cover crop mixtures and monocultures
Authors: de Souza Igor Alexandre , Daly Amanda B. , Schnecker Jörg , Warren Nicholas D. , Lobo Jr Adalfredo Rocha , Smith Richard G. , Brito Andre Fonseca , Grandy A. Stuart 
Published: July 2023

AbstractIncreasingly, cover crops are being adopted for the purpose of improving soil health, yet the timescale and magnitude by which living annual cover crops might modify soil chemical and biological aspects of soil health is not well understood. At the same time, there is growing interest among farmers in cover crop mixtures due to perceptions that species‐rich cover crop communities will enhance soil health relative to monocultures. In a field experiment in southeast New Hampshire, we investigated how groups of cover crops grown as monocultures and mixtures for specific seasonal niches (winter/spring, summer, and fall) influenced levels of soil nitrogen (N) and carbon (C), microbial biomass carbon (MBC), and nitrogen (MBN). Soils were sampled at cover crop maturity (winter/spring group), and at seeding, mid‐season, and maturity (summer and fall groups). In the winter/spring group, average total soil N ranged from 0.192 to 0.215 mg g−1 dry soil; highest total soil C content was 2.66 mg g−1 dry soil; and average MBC ranged from 304.8 to 387.3 μg C g−1 dry soil. In the summer group soil MBC decreased from 909.5 μg C g−1 dry soil at mid‐season to 644.9 μg C g−1 dry soil at the end of the growth cycle. In the fall group MBC fell and rose over the season in the range of 236.0–808.3 μg C g−1 dry soil. We found little evidence that cover crops influenced soil C and N parameters during the cover crop growth period relative to a weedy control or that mixtures differed from monocultures. MBC and MBN were more influenced by seasonality than the composition or diversity of the cover crop stand.
Interhemispheric Structural Connectivity Underlies Motor Recovery after Stroke
Authors: Paul Theresa , Wiemer Valerie M. , Hensel Lukas , Cieslak Matthew , Tscherpel Caroline , Grefkes Christian , Grafton Scott T. , Fink Gereon R. , Volz Lukas J. 
Published: July 2023

ObjectiveAlthough ample evidence highlights that the ipsilesional corticospinal tract (CST) plays a crucial role in motor recovery after stroke, studies on cortico‐cortical motor connections remain scarce and provide inconclusive results. Given their unique potential to serve as structural reserve enabling motor network reorganization, the question arises whether cortico‐cortical connections may facilitate motor control depending on CST damage.MethodsDiffusion spectrum imaging (DSI) and a novel compartment‐wise analysis approach were used to quantify structural connectivity between bilateral cortical core motor regions in chronic stroke patients. Basal and complex motor control were differentially assessed.ResultsBoth basal and complex motor performance were correlated with structural connectivity between bilateral premotor areas and ipsilesional primary motor cortex (M1) as well as interhemispheric M1 to M1 connectivity. Whereas complex motor skills depended on CST integrity, a strong association between M1 to M1 connectivity and basal motor control was observed independent of CST integrity especially in patients who underwent substantial motor recovery. Harnessing the informational wealth of cortico‐cortical connectivity facilitated the explanation of both basal and complex motor control.InterpretationWe demonstrate for the first time that distinct aspects of cortical structural reserve enable basal and complex motor control after stroke. In particular, recovery of basal motor control may be supported via an alternative route through contralesional M1 and non‐crossing fibers of the contralesional CST. Our findings help to explain previous conflicting interpretations regarding the functional role of the contralesional M1 and highlight the potential of cortico‐cortical structural connectivity as a future biomarker for motor recovery post‐stroke. ANN NEUROL 2023;94:785–797
MXene‐Regulated Metal‐Oxide Interfaces with Modified Intermediate Configurations Realizing Nearly 100% CO2 Electrocatalytic Conversion
Authors: Hao Yanan , Hu Feng , Zhu Shangqian , Sun Yajie , Wang Hui , Wang Luqi , Wang Ying , Xue Jianjun , Liao Yen‐Fa , Shao Minhua , Peng Shengjie 
Published: July 2023

AbstractElectrocatalytic CO2 reduction via renewable electricity provides a sustainable way to produce valued chemicals, while it suffers from low activity and selectivity. Herein, we constructed a novel catalyst with unique Ti3C2Tx MXene‐regulated Ag−ZnO interfaces, undercoordinated surface sites, as well as mesoporous nanostructures. The designed Ag−ZnO/Ti3C2Tx catalyst achieves an outstanding CO2 conversion performance of a nearly 100% CO Faraday efficiency with high partial current density of 22.59 mA cm−2 at −0.87 V versus reversible hydrogen electrode. The electronic donation of Ag and up‐shifted d‐band center relative to Fermi level within MXene‐regulated Ag−ZnO interfaces contributes the high selectivity of CO. The CO2 conversion is highly correlated with the dominated linear‐bonded CO intermediate confirmed by in situ infrared spectroscopy. This work enlightens the rational design of unique metal‐oxide interfaces with the regulation of MXene for high‐performance electrocatalysis beyond CO2 reduction.
Group‐Transfer Polymerization‐Induced Self‐Assembly (GTPISA) in Non‐polar Media: An Organocatalyzed Route to Block Copolymer Nanoparticles at Room Temperature
Authors: Stiti Assia , Cenacchi Pereira Ana Maria , Lecommandoux Sébastien , Taton Daniel 
Published: July 2023

AbstractPolymerization‐induced self‐assembly (PISA) enables the synthesis at large scale of a wide variety of functional nanoparticles. However, a large number of works are related to controlled radical polymerization (CRP) methods and are generally undertaken at elevated temperatures (>50 °C). Here is the first report on methacrylate‐based nanoparticles fabricated by group transfer polymerization‐induced self‐assembly (GTPISA) in non‐polar media (n‐heptane). This GTPISA process is achieved at room temperature (RT) using 1‐methoxy‐1‐(trimethylsiloxy)‐2‐methylprop‐1‐ene (MTS) and tetrabutylammonium bis‐benzoate (TBABB) as initiator and organic catalyst, respectively. Under these conditions, well‐defined metal‐free and colorless diblock copolymers are produced with efficient crossover from the non‐polar stabilizing poly(lauryl methacrylate) (PLMA) block to the non‐soluble poly(benzyl methacrylate) (PBzMA) segment. The resulting PLMA‐b‐PBzMA block copolymers simultaneously self‐assemble into nanostructures of various sizes and morphologies. GTPISA in non‐polar solvent proceeds rapidly at RT and avoids the use of sulfur or halogenated compounds or metallic catalysts associated with the implementation of CRP methods, thus expanding the potential of PISA formulations for applications in non‐polar environments.
Robust Proton Conduction against Mechanical Stress in Flexible Free‐Standing Membrane Composed of Two‐Dimensional Coordination Polymer
Authors: Lu Jiangfeng , Yoshida Yukihiro , Kanamori Kazuyoshi , Kitagawa Hiroshi 
Published: July 2023

AbstractIntroduction of mechanical flexibility into proton‐conducting coordination polymers (CPs) is in high demand for future protonic applications such as fuel cells and hydrogen sensors. Although such mechanical properties have been primarily investigated in one‐dimensional (1D) CPs, in this study, we successfully fabricated highly flexible free‐standing CP membranes with a high surface‐to‐volume ratio, which is beneficial for enhanced performance in the aforementioned applications. We fabricated a layered CP, Cu2(NiTCPP) (H4(H2TCPP); 5,10,15,20‐tetrakis(4‐carboxyphenyl) porphyrin), in which a two‐dimensional (2D) square grid sheet composed of tetradentate nickel porphyrins and paddlewheel‐type copper dimers was connected to each other by weak van der Waals forces. The mechanical flexibility was evaluated by bending and tensile tests. The flexural and Young's moduli of the membrane were significantly higher than those of conventional Nafion membranes. Electrochemical impedance spectroscopy analysis revealed that the in‐plane proton conductivity of the membrane was maintained even under applied bending stress. Because the X‐ray diffraction analysis indicates that the proton‐conducting pathway through the hydrogen bonding network remains intact during the bending operation, our present study provides a promising strategy for the fabrication of new and advanced 2D CPs without using substrates or additional polymers for protonic devices.
A Fluorogenic DNAzyme for A Thermally Stable Protein Biomarker from Fusobacterium nucleatum, a Human Bacterial Pathogen
Authors: Feng Qian , Zakaria Sandy , Morrison Devon , Tram Kha , Gu Jim , Salena Bruno J. , Li Yingfu 
Published: July 2023

AbstractFusobacterium nucleatum has been correlated to many poor human conditions including oral infections, adverse pregnancies and cancer, and thus molecular tools capable of detecting this human pathogen can be used to develop diagnostic tests for them. Using a new selection method targeting thermally stable proteins without a counter‐selection step, we derived an fluorogenic RNA‐cleaving DNAzyme, named RFD‐FN1, that can be activated by a thermally stable protein target that is unique to F. nucleatum subspecies. High thermal stability of protein targets is a very desirable attribute for DNAzyme‐based biosensing directly with biological samples because nucleases found inherently in these samples can be heat‐inactivated. We further demonstrate that RFD‐FN1 can function as a fluorescent sensor in both human saliva and human stool samples. The discovery of RFD‐FN1 paired with a highly thermal stable protein target presents opportunities for developing simpler diagnostic tests for this important pathogen.
Highly‐Active Chiral Organic Photovoltaic Catalysts with Suppressed Charge Recombination
Authors: Li Yawen , Zhang Zhenzhen , Li Tengfei , Liang Yuanxin , Si Wenqin , Lin Yuze 
Published: July 2023

AbstractRecombination of free charges in organic semiconductors reduces the available photo‐induced charge‐carriers and restricts photovoltaic efficiency. In this work, the chiral organic semiconductors (Y6‐R and Y6‐S with enantiopure R‐ and S‐ chiral alkyl sidechains) are designed and synthesized, which show effective aggregation‐induced chirality through mainchain packing with chiral conformations in non‐centrosymmetric space groups with tilt chirality. Based on the analysis of spin‐injection, magnetic‐hysteresis loop, and thermodynamics and dynamics of the excited state, we suggest that the aggregation‐induced chirality can generate spin‐polarization, which suppresses charge recombination and offers more available charge‐carriers within Y6‐R and Y6‐S relative to the achiral counterpart (Y6). Then the chiral Y6‐R and Y6‐S show enhanced catalytic activity with optimal average hydrogen evolution rates of 205 and 217 mmol h−1 g−1, respectively, 60–70 % higher than Y6, when they are employed as nanoparticle photocatalysts in photocatalytic hydrogen evolution under simulated solar light, AM1.5G, 100 mW cm−2.
Nucleophilic Attack at Pentaarsaferrocene [Cp*Fe(η5‐As5)]—The Way to Larger Polyarsenide Ligands
Authors: Reichl Stephan , Riesinger Christoph , Scheer Manfred 
Published: July 2023

AbstractBy the reaction of [Cp*Fe(η5‐As5)] (I) (Cp*=C5Me5) with main group nucleophiles, unique functionalized products with η4‐coordinated polyarsenide (Asn) units (n=5, 6, 20) are obtained. With carbon‐based nucleophiles such as MeLi or KBn (Bn=CH2Ph), the anionic organo‐substituted polyarsenide complexes, [Li(2.2.2‐cryptand)][Cp*Fe(η4‐As5Me)] (1 a) and [K(2.2.2‐cryptand)][Cp*Fe{η4‐As5(CH2Ph)}] (1 b), are accessible. The use of KAsPh2 leads to a selective and controlled extension of the As5 unit and the formation of the monoanionic compound [K(2.2.2‐cryptand][Cp*Fe(η4‐As6Ph2)] (2). When I is reacted with [M]As(SiMe3)2 (M=Li ⋅ THF; K), the formation of the largest known anionic polyarsenide unit in [M′(2.2.2‐cryptand)]2[(Cp*Fe)4{μ5‐η4:η4:η3:η3:η1:η1‐As20}] (3) occurred (M′=Li (3 a), K (3 b)).
Novel hydrazone‐isatin derivatives as potential EGFR inhibitors: Synthesis and in vitro pharmacological profiling
Authors: Ahmed Marwa F. , El‐Haggar Radwan , Almalki Atiah H. , Abdullah Omeima , El Hassab Mahmoud A. , Masurier Nicolas , Hammad Sherif F. 
Published: July 2023

AbstractMerging isatin and arylhydrazone moieties constitutes an efficient strategy to access new potential anticancer derivatives. Consequently, 14 hydrazone‐isatin derivatives were synthesized and evaluated for their antiproliferative activity against the NCI‐60 cancer cell line panel. A kinase assay demonstrated that compound VIIIb inhibited the epidermal growth factor receptor (EGFR), which was confirmed by docking studies, molecular dynamics, and binding free energy calculations. Further characterizations showed that this compound possesses drug‐likeness properties, showed a significant decrease of the cell population in the G2/M phase and led to a significant increase in early and late apoptosis, comparable to erlotinib. Also, VIIIb increased the expression of caspase‐3 and Bax and decreased the expression of Bcl‐2, confirming its potential as a new proapoptotic compound.
Time‐regularization event‐triggeredH∞control for switched linear systems with frequent asynchronism
Authors: Yu Yiman , Wang Yue‐E 
Published: July 2023

AbstractThis paper addresses the time‐regularization event‐triggered control problem for a class of continuous‐time switched systems with frequent asynchronism and external disturbances. In the system, both the system state and the switching information are transmitted to the controller only at the event‐triggered sampling instants, which may cause the occurrence of asynchronous switching behavior. To solve the problem, we first propose a time‐regularization event‐triggered mechanism, which not only avoids Zeno behavior efficaciously, but also allows the system to switch multiple times in the holding interval. Then, based on the time‐regularization event‐triggered mechanism, the error system is modeled as a sampled switched delay system with augmented switching signal. After that, sufficient conditions for the exponentially stability and weighted performance of the switched system under average dwell time are derived by constructing multiple switching Lyapunov functions. Finally, a circuit example is given to illustrate the effectiveness of the proposed method.