bluuebunny/crossref_metadata_2025_split huggingface dataset:
The blood vasculature instructs lymphatic patterning in a SOX7‐dependent manner
Authors: Chiang Ivy K N , Graus Matthew S , Kirschnick Nils , Davidson Tara , Luu Winnie , Harwood Richard , Jiang Keyi , Li Bitong , Wong Yew Yan , Moustaqil Mehdi , Lesieur Emmanuelle , Skoczylas Renae , Kouskoff Valerie , Kazenwadel Jan , Arriola‐Martinez Luis , Sierecki Emma , Gambin Yann , Alitalo Kari , Kiefer Friedmann , Harvey Natasha L , Francois Mathias 
Published: January 2023

AbstractDespite a growing catalog of secreted factors critical for lymphatic network assembly, little is known about the mechanisms that modulate the expression level of these molecular cues in blood vascular endothelial cells (BECs). Here, we show that a BEC‐specific transcription factor, SOX7, plays a crucial role in a non‐cell‐autonomous manner by modulating the transcription of angiocrine signals to pattern lymphatic vessels. While SOX7 is not expressed in lymphatic endothelial cells (LECs), the conditional loss of SOX7 function in mouse embryos causes a dysmorphic dermal lymphatic phenotype. We identify novel distant regulatory regions in mice and humans that contribute to directly repressing the transcription of a major lymphangiogenic growth factor (Vegfc) in a SOX7‐dependent manner. Further, we show that SOX7 directly binds HEY1, a canonical repressor of the Notch pathway, suggesting that transcriptional repression may also be modulated by the recruitment of this protein partner atVegfcgenomic regulatory regions. Our work unveils a role for SOX7 in modulating downstream signaling events crucial for lymphatic patterning, at least in part via the transcriptional repression of VEGFC levels in the blood vascular endothelium.
Recognition of the CCT5 di‐Glu degron by CRL4DCAF12 is dependent on TRiC assembly
Authors: Pla‐Prats Carlos , Cavadini Simone , Kempf Georg , Thomä Nicolas H 
Published: January 2023

AbstractAssembly Quality Control (AQC) E3 ubiquitin ligases target incomplete or incorrectly assembled protein complexes for degradation. The CUL4‐RBX1‐DDB1‐DCAF12 (CRL4DCAF12) E3 ligase preferentially ubiquitinates proteins that carry a C‐terminal double glutamate (di‐Glu) motif. Reported CRL4DCAF12 di‐Glu‐containing substrates include CCT5, a subunit of the TRiC chaperonin. How DCAF12 engages its substrates and the functional relationship between CRL4DCAF12 and CCT5/TRiC is currently unknown. Here, we present the cryo‐EM structure of the DDB1‐DCAF12‐CCT5 complex at 2.8 Å resolution. DCAF12 serves as a canonical WD40 DCAF substrate receptor and uses a positively charged pocket at the center of the β‐propeller to bind the C‐terminus of CCT5. DCAF12 specifically reads out the CCT5 di‐Glu side chains, and contacts other visible degron amino acids through Van der Waals interactions. The CCT5 C‐terminus is inaccessible in an assembled TRiC complex, and functional assays demonstrate that DCAF12 binds and ubiquitinates monomeric CCT5, but not CCT5 assembled into TRiC. Our biochemical and structural results suggest a previously unknown role for the CRL4DCAF12 E3 ligase in overseeing the assembly of a key cellular complex.
A Novel Creatinine Muscle Index Based on Creatinine Filtration: Associations with Frailty and Mortality
Authors: Ballew Shoshana H. , Zhou Linda , Surapaneni Aditya , Grams Morgan E. , Windham B. Gwen , Selvin Elizabeth , Coresh Josef , Miao Shiyuan , Inker Lesley A. , Levey Andrew S. 
Published: January 2023

Background
Low muscle mass is related to frailty and increased mortality in older adults. However, muscle mass is not easily assessed in routine clinical practice.

Methods
This study describes a novel creatinine muscle index (CMI) on the basis of serum creatinine and cystatin C in a community-based sample of older adults from the Atherosclerosis Risk in Communities Study. Analyses included 4639 participants who attended visit 5 (2011–2013) and 12,786 participants who attended visit 2 (1990–1992). CMI was defined as creatinine filtration (the product of serum creatinine times eGFR on the basis of cystatin C) and was analyzed in sex-specific tertiles. Cross-sectional associations of CMI with a frailty trichotomy, defined by the number (robust [0]/prefrail [1–2]/frail [3–5]) of five frailty components (weight loss, slowness, exhaustion, weakness, and low physical activity), were studied using polychotomous logistic regression and binary logistic regression with each frailty component. Cox regression was used to estimate associations of CMI at visit 5 and visit 2 with mortality. Models were adjusted for demographics, clinical variables, and comorbid conditions.

Results
CMI (tertile 1 versus 3) was moderately associated with frailty (visit 5: adjusted odds ratio 4.23 [95% CI, 2.02 to 8.87] in men and 2.34 [95% CI, 1.41 to 3.89] in women) and with mortality (visit 5: adjusted hazard ratio 1.45 [95% CI, 1.08 to 1.94] in men and 1.55 [95% CI, 1.13 to 2.12] in women; similar results were seen at visit 2).

Conclusion
Lower CMI was associated with frailty and increased mortality, two clinical outcomes known to be associated with decreased muscle mass. Creatinine filtration may be an index of muscle mass and have utility in clinical practice, particularly at low levels.
ADVANCED MATERIALS AND RESEARCH FOR THE GREEN FUTURE
Authors: Podgornik Bojan 
Published: January 2023

Environmental concerns, such as pollution, greenhouse-gas emissions, sustainability, global warming and climate change, are the biggest challenges of our times. In this respect, the more efficient use of energy and materials combined with technology optimization and innovation are playing a key role in the quest to become a green society with green industry. Multiple environmental and economic benefits can mostly be achieved through novel, lightweight energy-efficient designs. In order to develop and properly use new materials and new designs, complete understanding and information on their properties must be obtained. It is also vital to know how these properties are affected by the conditions of a specific application. Furthermore, as the design of components is pushed towards the limits, unsuitable and outdated measuring methods, measuring uncertainty and deviations from the defined material properties can lead to unexpected premature failure of the component and environmental problems.
For the green future, it is extremely important to develop new, advanced materials. However, it is often the changes of the production technology and to the surface of an already-existing material that can achieve great benefits to performance as well as the environment. It is all about modifying the material to perform better, last longer, be biocompatible and achieve different functionalities. Finally, besides high-tech equipment and research facilities, close cooperation between universities, research institutes and industry is needed to develop technologies, functional materials and solutions that can effectively support the journey of our society into a green future
Para desmitificar a Mito
Authors: Gilard Jacques 
Published: January 2023

A pesar del reconocimiento de que la revista Mito (1955-1962) tuvo en Colombia una importancia indiscutible en torno a la difusión de la cultura literaria, política y social, y a debates relativos a la lucha por la libertad, es innegable, también, que dicho reconocimiento ha sobrepasado los límites de la ecuanimidad. Mediante un elogio desmesurado de la revista y de sus gestores Jorge Gaitán Durán, Eduardo Cote Lamus y Hernando Valencia Goelkel, se ha ocultado sistemáticamente el papel y la importancia de publicaciones y de intelectuales y artistas que antecedieron a la revista bogotana. Mito es incomparable sólo si se anula la existencia de Jorge Zalamea y de su quincenario Crítica. Descriptores: Revistas colombianas; revista Mito; Zalamea, Jorge; Crítica; el centro y las márgenes. Abstract: Although the journal Mito (1955-1962) was considerably appreciated in Colombia for its undeniable importance around the spread of literary, political and social culture, and about the debates related to the fight for freedom, it is also undeniable that such recognition has surpassed the limities of ecuanimity. Through an excessive apology of the journal and its founders, Jorge Gaitán Durán, Eduardo Cote Lamus y Hernando Valencia Goelkel, the role and importance of publications, intellectuals and artists previous to the journal from Bogotá have been systematically forgotten. Mito is unsurpassed only if we deny the existence of Jorge Zalamea and his biweekly journal Crítica. Key words: Colombian journals; Journal Mito; Zalamea, Jorge; Crítica; center and margins.
El subsidio al precio del oro en Colombia
Authors: Lobo Urquijo Alvaro Augusto 
Published: January 2023

• Resumen: En el mes de marzo de 1984 la Junta Monetaria estableció un subsidio al precio del oro en Colombia, el cual estuvo vigente hasta el mes de septiembre de 1986. Durante ese período, las ventas del mineral al Banco de la República alcanzaron niveles sin precedentes. La creencia de que parte de ese oro provenía del exterior suscitó una gran controversia en el país. En este artículo se examinan los efectos de aquella medida en la balanza cambiaría y se intenta identificar la capacidad de respuesta de las diferentes formas de producción auríferas a la variación de los precios, a fin de evaluar la eficacia de la política de sobreprecio adelantada en esos años. • Abstract: Between the months of March 1984 and September 1986 the internal price of gold in Colombia was subsidized. During that period gold sales to the Banco de la República (the central bank) reached unprecedented levels. The suspicion that part of this gold arrived from outside the country provoked a controversy. This paper examines the effects of the subsidy on the commercial balance and tries to identify the potential responses of different types of gold production to such price changes, as well as assessing the efficacy of the policy experiment.
La constitución de 1886 como respuesta a la crisis del modelo federal y la confrontación nación-región en Colombia
Authors: Uribe de Hincapie María Teresa , Alvarez Gaviria Jesús María 
Published: January 2023

• Resumen: En este artículo, los autores analizan las condiciones históricas de Colombia en la segunda mitad del siglo XIX, más propiamente en el período en que tuvo vigencia el Régimen Federal, que se inicia con la Constitución de 1863 y termina con la Constitución de 1886. En el estudio se aborda el análisis del proceso económico interno para mostrar su profundo fraccionamiento y la marcada diferenciación regional, en oposición al modelo generalmente aceptado por la historiografía tradicional, que supone en lo político la existencia de un espacio nacional neutralizado, y en lo económico privilegia la influencia de las condiciones del desarrollo del capitalismo mundial como explicativas del desarrollo del país y de los determinantes de su sujeción a las leyes generales del sistema capitalista. Como una alternativa teórico-metodológica se asume la actividad comercial no solo como una vía de acumulación de capital-dinero sino como un medio de configuración de poder económico y político que unificó los intereses de las élites regionales en torno a un proyecto común. El elemento aglutinante de las particularidades regionales es la actividad especulativa del capital mercantil. De esta manera el Régimen Federal permitió, contradictoriamente, unificar las particularidades regionales que lo sustentaron, e hizo posible así el proyecto centralista de La Regeneración que se concentró en la Constitución de 1886. • Abstract: The 1886 Constitution as on answer to the Federal Model's crisis and the nation-region confrontation in Colombia. In this article, the authors analyze the historical conditions in Colombia, during the second half of the nineteenth century, particularly the period during which the Federal Regime prevailed beginning with the Constitution in 1883 and concluding with the 1886 Constitution. This paper treats the analysis of the internal economy process in order to show its pronounced division and regional differentiation, as opposed to th
Uso del suelo, ciclo agrícola y unidades productivas en el suroeste de Antioquia, 1912-1935. Aproximación empírica y comparativa
Authors: Samper Kutsbach Mario 
Published: January 2023

• Resumen: El trabajo presenta una visión detallada de las características del uso de la tierra y la ocupación de fuerza de trabajo, tanto asalariada como familiar, en diversos tipos de unidades productivas del suroeste antioqueño en el período estudiado. Retoma hipótesis de un estudio anterior sobre la región entre 1850 y 1912 para explicar el impacto de la progresiva especialización caficultora sobre los ciclos de labores agrícolas y sobre la interacción entre productores directos y dueños del capital. Propone algunas posibilidades de análisis comparativo y ciertos referentes de tipo conceptual. • Abstract: The paper discusses in a detailed form the current characteristics of the land use and labor force, in wage form as well as familiar, within different types of productive unities in the area under examination related to the period. It returns to the hypothesis of a previous study on the Antioquia south west between 1850-1912, in order to explain the impact of the progressive coffee specialization over the agricultural cycles and over the interaction between direct producers and capital owners. It suggests some possibilities of comparative analysis and certain related of conceptual order.
Modelo económica de demanda de energía eléctrica en la industria colombiana
Authors: Botero Jesús , Castaño Elkin , Vélez Carlos Eduardo 
Published: January 2023

Este artículo busca encontrar los determinantes económicos de la demanda industrial de energía eléctrica en Colombia durante el período 1970-1983. La estimación de las ecuaciones de demanda derivadas de la función translogarítmica de costos muestra la complementariedad o sustituibilidad entre energía y otros insumos de la función de producción industrial. Tras constatar la complementariedad entre energía y capital, se estima la demanda de energía en función del stock de capital de la industria. Para evitar supuestos ad-hoc sobre el capital inicial, se utilizó un modelo especial que deja esta variable como un parámetro de estimación. De otro lado, el comportamiento optimizador de los industriales determina las participaciones relativas de las compras a la red y la autogeneración en los gastos de energía. Este proceso se representa como un proceso de minimización sujeto a una función de producción CES o Finalmente, con el objeto de mejorar la precisión de los estimadores se aplica el método del Bootstrap.
Meditation and Yoga in pregnancy: maternal and fetal impact
Authors: Mehta Sumita , Grover Anshul , Kale Ekta , Nanda Pratibha , Mehta Akshaj 
Published: January 2023

Background: Yoga is a practice which amalgamates the emotional, mental, physical and spiritual aspects of the human body through physical postures(asanas), breathing exercises (pranayama), concentration and meditation (dharana and dhyana). Evaluation of databases suggests a positive role of yoga in pregnancies associated with depression, anxiety and lumbosacral pain and also in reducing antepartum complications and pain score during labor. These beneficial effects of yoga are suggested but more systematic researches are required to validate it. With the background of above researches, we undertook the study to evaluate the effect of prenatal yoga and meditation on maternal and fetal outcomes. Aim of the study was to determine the effect of antenatal meditation and yoga on obstetric and fetal outcome.
Methods: This was a prospective randomized trial conducted in the antenatal OPD of the institute. Sixty primigravida women with low risk pregnancy between 18 to 26 weeks gestation were included in the trial.They were randomly divided into two equal groups; interventional group underwent meditation and yoga sessions of 30 minutes twice in a week till delivery. Obstetric outcomes including gestational age, antepartum and intrapartum complications, cord blood cortisol levels at delivery and neonatal outcomes were recorded.
Results: Thirteen women went post-dated as compared to 3 in the interventional group which was statistically significant (p=0.0003). APGAR scores of neonates in the interventional group showed a highly significant improvement with p=0.0013 as compared to the control group. Cord blood cortisol levels were higher than 10 ng/ml in 16 women in the control group compared to 7 in the group who performed yoga and meditation with p=0.01. NICU admissions were significantly more (p=0.002) in the control group.
Conclusions: Meditation and yoga during pregnancy improves maternal and neonatal outcomes.
Reservoir Modeling, History Matching, and Characterization with a Reservoir Graph Network Model
Authors: Guo Zhenyu , Sankaran Sathish , Sun Wenyue 
Published: January 2023

Summary
Efficient reservoir models are more desirable for fast-paced reservoir management. Moreover, due to the complexity of flow underground, it is also essential to capture the fundamental physics for model reliability. Although they are fast, pure data-driven models frequently have issues associated with interpretability, physical consistency, and ability to forecast. On the other hand, we have used full-physics simulation models to mimic and investigate hydrocarbon systems for over several decades. However, considering its infrequent model updates related to high model complexity, it is a big challenge to manage reservoirs using full-physics models in short cycles. The objective here is to propose an approach that blends reservoir physics with data-driven models to fit in the framework of dynamic reservoir management.
We propose to use a reservoir graph network (RGNet) modeling approach based on a diffusive time-of-flight (DTOF) concept to simulate reservoir behaviors. By assimilating field observation data (such as pressure and rates), an RGNet model can be used for future predictions, scenario studies, and well-control optimizations. By discretizing DTOF of a 3D system with multiple wells, RGNet simplifies the system into a graph network represented by a set of 1D grid blocks that significantly reduces the system complexity and run time. RGNet can also handle multiple flow problems with various types of physics. In this work, we propose to use two methods to develop reliable and parsimonious models scalable to large-scale systems. In addition, we propose a more robust method to assimilate pressure data.
We applied the proposed approach to a synthetic and a field example. Two different history-matching algorithms, the ensemble smoother with multiple data assimilation (ES-MDA) and an adjoint-based method, are compared. While ES-MDA provides the capability for uncertainty analysis, an adjoint-based method generally requires fewer simulation runs to generate a posterior model. With the proposed methods for generating interwell connections, RGNet model calibration can be achieved without system redundancy and spurious long-distance well connectivity. Also, by using a more stable pressure-matching technique, we show that pressure data are better matched and reservoir volume is accurately characterized.
RGNet provides a novel hybrid physics and data-driven reservoir modeling method to fit in closed-loop reservoir management (CLRM). As RGNet models are combined with fundamental flowing physics, the calibrated model parameters are easy to interpret and understand. An RGNet model runs with far less computational cost than required by a full-physics model, which allows it to be a more practical solution to history match, predict, and optimize real assets.
Data-Driven Reduced-Order Model for Multiphase Flow in Annulus with Air and Cavitation Effect
Authors: Hao Yitong , Tang Yingjie , Grigoriadis Karolos , Franchek Matthew A. 
Published: January 2023

Summary
For multiphase (water-liquid, water-vapor, and air) flow in a sharp-edge converging-diverging annulus, when the downstream/upstream pressure ratio is low, the cavitation phenomenon could occur in the contraction area if the liquid pressure drops below its vaporization pressure. The occurrence of the cavitation will contribute to choked flow, affect the local flow velocity field, and limit the flow rate through the annulus, resulting in damages to the annulus surfaces. In this paper, we use the turbulence model (k-ω) and the multiphase models [volume-of-fluid (VOF) and Eulerian] to simulate the liquid-vapor-gas flow with cavitation in the near-closing annulus. The closing percentage of the annulus varies from 50 to 90% in this numerical investigation. This study compares the VOF and the Eulerian models in liquid-vapor-gas multiphase flow computational fluid dynamics (CFD) simulation results. Furthermore, the effect of gas volume fraction (GVF) at the inlet boundary of the computational domain on the cavitation characteristics is analyzed. The analysis of the simulation results suggests that the choked flow rate and the discharge coefficient gradually decrease with the increase in GVF. Conversely, as the GVF grows within the required range (0–20%), the critical pressure ratio for cavitation increases. In this study, we developed data-driven nondimensional models based on such numerical investigations to predict the choked flow rate and the critical pressure ratio in the multiphase (water-liquid, water-vapor, and air) annulus flow. The findings can provide numerical guidance for the experimental design of annulus multiphase cavitation flow and serve as an engineering tool for flow prediction in offshore oil and gas applications.
Flow Control Valve Valuation and Value of Information under Uncertainty
Authors: Bailey William , Prange Michael 
Published: January 2023

Summary
An analysis is presented that quantifies the value-adding brought to a well by installing downhole flow control valves (FCVs) in a reservoir with uncertainties represented by multiple equiprobable realizations, two aquifer strengths, and three oil/water contacts (OWCs). The complexity of the model makes nonintuitive its response to FCV adjustment. From an openhole (OH) baseline net present value (NPV), it was possible to extract specific value-adding for the following, nonadjustable valves, the ability to adjust the valve, and how future information can add further value. The issue of measurement bin size is discussed, and the implication of making them too large, or too small, is described. Finally value erosion due to valve failure is also addressed. The solution presented used dynamic programming (DP), which was validated against a full enumeration of the problem using reservoir simulation. Approaches to proxies to traverse the (potentially large) decision space are also discussed.