Development of the global inflammatory bowel disease visualization of epidemiology studies in the 21st century (GIVES-21)
Authors: Mak Joyce W. Y. , Sun Yang , Limsrivilai Julajak , Abdullah Murdani , Kaibullayeva Jamilya , Balderramo Domingo , Vergara Beatriz Iade , Paudel Mukesh Sharma , Banerjee Rupa , Hilmi Ida , Ali Raja Affendi Raja , Wei Shu Chen , Ng Ka Kei , Altuwaijri Mansour , Kelly Paul , Yamamoto-Furusho Jesus K. , Kotze Paulo Gustavo , Ahuja Vineet , Chong Vui Heng , Dao Hang Viet , Abbey Yvonne , Ching Jessica Y. L. , Ho Agnes , Chan Alicia K. W. , Bernstein Charles N. , Gearry Richard B. , Abreu Maria , Rubin David T. , Dotan Iris , Hracs Lindsay , Kaplan Gilaad G. , Ng Siew C. ,   On behalf of the GIVES-21 Consortium, Tao Yan , Rong Jiamei , Chen Xiaocui , Song Huixian , Zhou Chan , Mu Yanju , Wei Wenjuan , Bai Xinyu , Aniwan Satimai , Kitiyakara Taya , Harinwan Kamin , Bunchorntavakul Chalermrat , Techathuvanan Karjpong , Kijdamrongthum Phuripong , Suttichaimongkol Tanita , Wetwittayakhlang Panu , Simadibrata Marcellus , Syam Ari Fahrial , Larasati Deka , Tedjasaputra Tjahjadi Robert , Saragih Arlyando Hezron , Koncoro Hendra , Kanabayeva Aizhan , Kongyrbayeva Nazira , Kurmangaliyeva Assem , Laryushina Yelena , Perizat Toktarova , Venera Ayupova , Aidana Kaliyakparova , Toscani Ignacio , Nicoloff Luciana , Howe Marie , Khoo Xin Hui , Heng Wong Choon , Singh Harjinder , Chua Andrew , Hong Khong Wai , Weng Meng-Tzu , Lin Wei-Chen , Lee Hsi-Chang , Chang Chun-Chao , Lin Chun-Chi , Le Puo Hsien , Huang Tien-Yu , Sun Cheuk-Kay , Yeh Hsing-Jung , Ho Yu Hon , AlIbrahim Bashaar , Alahmari Mohammed , Hodges Phoebe , Nsokolo Bright , Awuku Yaw , Li Michael , Chan Kam Hon , Man Yip Wai , Yun-Sze Thomas Wong , Fong Alex 
Published: May 2023

Abstract
Background
There is a rapid increase in the incidence of inflammatory bowel diseases (IBD) in newly industrialized countries, yet epidemiological data is incomplete. We herein report the methodology adopted to study the incidence of IBD in newly industrialized countries and to evaluate the effect of environmental factors including diet on IBD development.

Methods
Global IBD Visualization of Epidemiology Studies in the 21st Century (GIVES-21) is a population-based cohort of newly diagnosed persons with Crohn’s disease and ulcerative colitis in Asia, Africa, and Latin America to be followed prospectively for 12 months. New cases were ascertained from multiple sources and were entered into a secured online system. Cases were confirmed using standard diagnostic criteria. In addition, endoscopy, pathology and pharmacy records from each local site were searched to ensure completeness of case capture. Validated environmental and dietary questionnaires were used to determine exposure in incident cases prior to diagnosis.

Results
Through November 2022, 106 hospitals from 24 regions (16 Asia; 6 Latin America; 2 Africa) have joined the GIVES-21 Consortium. To date, over 290 incident cases have been reported. All patients have demographic data, clinical disease characteristics, and disease course data including healthcare utilization, medication history and environmental and dietary exposures data collected. We have established a comprehensive platform and infrastructure required to examine disease incidence, risk factors and disease course of IBD in the real-world setting.

Conclusions
The GIVES-21 consortium offers a unique opportunity to investigate the epidemiology of IBD and explores new clinical research questions on the association between environmental and dietary factors and IBD development in newly industrialized countries.