bluuebunny/crossref_metadata_2025_split huggingface dataset:
Short pathways to highly active antimicrobial: structurally diverse polyamines derivatives from Amino‐Aldehyde condensation strategy
Authors: Ma Yue , Zhou Han , Wang Yi‐Rong , Zhang Bao‐Qi , Zhang Zhi‐Jun , Peng Deng , An Jun‐Xia , Zhang Shao‐Yong , Luo Xiong‐Fei , Wang Guang‐Han , Ding Yan‐Yan , Zhao Wen‐Bin , Hu Yong‐Mei , Liu Ying‐Qian 
Published: August 2023

AbstractBACKGROUNDChemical fungicides are the mainstay of plant disease control in agricultural production, but there are a very limited number of drugs that can effectively control plant diseases. Two series of secondary amine derivatives were synthesized using the diamine skeleton combined with saturated aromatic and aliphatic aldehydes, and their antibacterial and antifungal activities against plant pathogens were determined. In addition, the antimicrobial mechanism of the highly active compound A26 was preliminarily examined against Xanthomonas oryzae (Xoo).RESULTSCompound A26 exhibited the highest antibacterial potency among all the target compounds, with MIC values of 3.12, 3.12 and 12.5 μg mL−1 against Xoo, Xanthomonas axonopodis pv. Citri and Pseudomonas sollamacearum, respectively. In addition, compound A26 had powerful curative and protective effects against Xoo at 200 μg mL−1, and was better than the control agent Xinjunan. Preliminary mechanistic studies showed that compound A26 reduced the bacterial pathogenicity by targeting cell membranes and inhibiting the secretion of extracellular polysaccharides. Meanwhile, the toxicity of compound A26 to Human Embryonic Kidney 293 cells and Human Liver‐7702 was similar to that of Xinjunan, and it had moderate toxicity according to the World Health Organization classification standard of oral exogenous toxicity, with an LD50 of 245.47 mg kg−1.CONCLUSIONSecondary amines have efficient and broad‐spectrum antibacterial activity against plant pathogenic bacteria and are expected to be a new class of candidate compounds for antibacterial drugs. © 2023 Society of Chemical Industry.
Leverage target and R&D spending
Authors: Azim Khan Sharier 
Published: August 2023

AbstractIn this paper, I examine how capital structure (relative to target) affects the financing of R&D spending. Studies on capital structure have shown that firms adjust their debt levels toward target debt levels. I show that firms with below‐target debt are more likely to issue debt to finance R&D spending compared to firms that have above‐target debt. The results are stronger for firms that are smaller in size and firms that do not pay dividends. I also show that firms with below‐target debt are more likely to use a greater fraction of proceeds from net debt issuance to finance R&D spending (either directly or indirectly).
Cooperative 3D tunnel measurement based on 2D–3D registration of omnidirectional laser light
Authors: Igaue Takuya , Hayamizu Toko , Higuchi Hiroshi , Ikura Mikihiro , Yoshida Kenichi , Yamanaka Satoshi , Yamaguchi Takashi , Asama Hajime , Yamashita Atsushi 
Published: August 2023

AbstractIn this study, we proposed a high‐density three‐dimensional (3D) tunnel measurement method, which estimates the pose changes of cameras based on a point set registration algorithm regarding 2D and 3D point clouds. To detect small deformations and defects, high‐density 3D measurements are necessary for tunnel construction sites. The line‐structured light method uses an omnidirectional laser to measure a high‐density cross‐section point cloud from camera images. To estimate the pose changes of cameras in tunnels, which have few textures and distinctive shapes, cooperative robots are useful because they estimate the pose by aggregating relative poses from the other robots. However, previous studies mounted several sensors for both the 3D measurement and pose estimation, increasing the size of the measurement system. Furthermore, the lack of 3D features makes it difficult to match point clouds obtained from different robots. The proposed measurement system consists of a cross‐section measurement unit and a pose estimation unit; one camera was mounted for each unit. To estimate the relative poses of the two cameras, we designed a 2D–3D registration algorithm for the omnidirectional laser light, and implemented hand‐truck and unmanned aerial vehicle systems. In the measurement of a tunnel with a width of 8.8 m and a height of 6.4 m, the error of the point cloud measured by the proposed method was 162.8 and 575.3 mm along 27 m, respectively. In a hallway measurement, the proposed method generated less errors in straight line shapes with few distinctive shapes compared with that of the 3D point set registration algorithm with Light Detection and Ranging.
Longitudinal relationship between psychological distress and personality traits
Authors: Joshanloo Mohsen 
Published: August 2023

AbstractPersonality traits are typically assumed to predict psychological distress, with little attention paid to the potential influence of psychological distress on personality traits. Recent empirical findings, however, challenge this prevailing view by demonstrating the potential for personality traits to change and suggesting the plausible influence of chronic distress on these traits. This study aimed to examine the mutual within‐person associations between psychological distress and the Big Five personality traits. The primary research question was whether a change in psychological distress is associated with a change in personality traits (and vice versa) after approximately 4 years. A nationally representative sample from Australia (N = 22,837), collected at four time points over 13 years, was used. The random‐intercept cross‐lagged panel model was used to partition variance into between‐person and within‐person components. Results showed that there was no temporal within‐person association between openness and distress. Extraversion and conscientiousness were found to have bidirectional within‐person relationships with distress, suggesting that increases in extraversion and conscientiousness are associated with decreases in distress over time and vice versa. Emotional stability and agreeableness showed unidirectional relationships with distress, with increased distress predicting decreased emotional stability and increased agreeableness predicting decreased distress. Therefore, except for openness, the other traits had at least one significant within‐person link to psychological distress. These findings unveil a reciprocal longitudinal linkage between personality traits and psychological distress, highlighting the potential negative impact of prolonged psychological distress on the developmental trajectory of personality traits.
Reconstituted Extracellular Vesicles from Human Platelets Decrease Viral Myocarditis in Mice
Authors: Beetler Danielle J. , Bruno Katelyn A. , Watkins Molly M. , Xu Vivian , Chekuri Isha , Giresi Presley , Di Florio Damian N. , Whelan Emily R. , Edenfield Brandy H. , Walker Sierra A. , Morales‐Lara Andrea C. , Hill Anneliese R. , Jain Angita , Auda Matthew E. , Macomb Logan P. , Shapiro Kathryn A. , Keegan Kevin C. , Wolfram Joy , Behfar Atta , Stalboerger Paul G. , Terzic Andre , Farres Houssam , Cooper Leslie T. , Fairweather DeLisa 
Published: August 2023

AbstractPatients with viral myocarditis are at risk of sudden death and may progress to dilated cardiomyopathy (DCM). Currently, no disease‐specific therapies exist to treat viral myocarditis. Here it is examined whether reconstituted, lyophilized extracellular vesicles (EVs) from platelets from healthy men and women reduce acute or chronic myocarditis in male mice. Human‐platelet‐derived EVs (PEV) do not cause toxicity, damage, or inflammation in naïve mice. PEV administered during the innate immune response significantly reduces myocarditis with fewer epidermal growth factor (EGF)‐like module‐containing mucin‐like hormone receptor‐like 1 (F4/80) macrophages, T cells (cluster of differentiation molecules 4 and 8, CD4 and CD8), and mast cells, and improved cardiac function. Innate immune mediators known to increase myocarditis are decreased by innate PEV treatment including Toll‐like receptor (TLR)4 and complement. PEV also significantly reduces perivascular fibrosis and remodeling including interleukin 1 beta (IL‐1β), transforming growth factor‐beta 1, matrix metalloproteinase, collagen genes, and mast cell degranulation. PEV given at days 7–9 after infection reduces myocarditis and improves cardiac function. MicroRNA (miR) sequencing reveals that PEV contains miRs that decrease viral replication, TLR4 signaling, and T‐cell activation. These data show that EVs from the platelets of healthy individuals can significantly reduce myocarditis and improve cardiac function.
Exploiting Ambipolarity in Graphene Field‐Effect Transistors for Novel Designs on High‐Frequency Analog Electronics
Authors: Pasadas Francisco , Medina‐Rull Alberto , Ruiz Francisco G. , Ramos‐Silva Javier Noe , Pacheco‐Sanchez Anibal , Pardo Mari Carmen , Toral‐Lopez Alejandro , Godoy Andrés , Ramírez‐García Eloy , Jiménez David , Marin Enrique G. 
Published: August 2023

AbstractExploiting ambipolar electrical conductivity based on graphene field‐effect transistors has raised enormous interest for high‐frequency (HF) analog electronics. Controlling the device polarity, by biasing the graphene transistor around the vertex of the V‐shaped transfer curve, enables to redesign and highly simplify conventional analog circuits, and simultaneously to seek for multifunctionalities, especially in the HF domain. This study presents new insights for the design of different HF applications such as power amplifiers, mixers, frequency multipliers, phase shifters, and modulators that specifically leverage the inherent ambipolarity of graphene‐based transistors.
Cooperative Synthesis of Raspberry‐Like Covalent Organic Framework‐Polymer Particles with a Radial Single‐Crystal Grain Orientation
Authors: Salaün Pauline , Fadel Alexandre , Pelaez‐Fernandez Mario , Mouloud Bahae‐Eddine , Tahon Jean‐François , Volkringer Christophe , Addad Ahmed , Woisel Patrice , Le Fer Gaëlle 
Published: August 2023

AbstractDespite many efforts devoted toward the design of covalent organic frameworks (COFs) at the framework level by selecting the building blocks, their organization in the nano to meso regimes is often neglected. Moreover, the importance of processability for their applications has recently emerged and the synthesis of COF nanostructures without agglomeration is still a challenge. Herein, the first example of hybrid COF‐polymer particles for which polymers are used to manipulate the 2D COF growth along a specific direction is reported. The study examines how the nature, chain‐end functionality, and molar mass of the polymer influence the shaping of hybrid 2D boronate ester‐linked COF‐polymer particles. Catechol‐poly(N‐butyl acrylate) leads to the self‐assembly of crystallites into quasi‐spherical structures while catechol‐poly(N‐isopropylacrylamide) mediates the synthesis of raspberry‐like COF‐polymer particles with radial grain orientation. Scanning and transmission electron microscopies (SEM and TEM) and 4D‐STEM‐ACOM (automated crystal orientation mapping) highlight the single‐crystal character of these domains with one plane family throughout the particles. Interestingly, the presence of PNIPAm on the particle surface allows their drying without co‐crystallization and enables their resuspension. Kinetic investigations show that catechol‐PnBuA acts as a modulator and catechol‐PNIPAm induces a template effect, introducing supramolecular self‐assembly properties into particles to create new morphologies with higher structural complexity, beyond the framework level.
High Thermoelectric Performance of Non‐Stoichiometric and Oriented GeTe Thin Films
Authors: Zhang Xiaohe , Lu Xiaowei , Jiang Peng , Bao Xinhe 
Published: August 2023

AbstractThe increasing demand for micro‐thermoelectric coolers and generators promotes the research on thermoelectric (TE) thin films. As a promising medium‐temperature TE material, GeTe has attracted wide attention recently. However, the thermoelectric performance of thin‐film GeTe remains inferior. Herein, oriented GeTe films with excessive Ge are obtained by magnetron co‐sputtering technique, which can not only reduce the carrier concentration but also increase the carrier mobility, maintaining the high electrical conductivity of GeTe. Furthermore, higher structural symmetry and grain boundary scattering enhance the Seebeck coefficient of oriented GeTe films. As a result, the power factor (PF) value can reach as high as 2848 µW m−1 K−2 at room temperature and increase to 5263 µW m−1 K−2 at 600 K. Furthermore, a TE device with the Ge‐rich GeTe thin film is fabricated and the maximum output power density (power per unit area) reaches 0.3 W cm−2 at ΔT = 250 K. This work demonstrates that the stoichiometry and orientation modulations are effective strategies to improve the thermoelectric performance of GeTe thin films.
Ultra‐Large Scale Stitchless AFM: Advancing Nanoscale Characterization and Manipulation with Zero Stitching Error and High Throughput
Authors: Liu Yijie , Li Xuexuan , Zhang Yuliang , Ge Lin , Guan Yingchun , Zhang Zhen 
Published: August 2023

AbstractThe atomic force microscopy (AFM) is an important tool capable of characterization, measurement, and manipulation at the nanoscale with a vertical resolution of less than 0.1 nm. However, the conventional AFMs' scanning range is around 100 µm, which limits their capability for processing cross‐scale samples. In this study, it proposes a novel approach to overcome this limitation with an ultra‐large scale stitchless AFM (ULSS‐AFM) that allows for the high‐throughput characterization of an area of up to 1 × 1 mm2 through a synergistic integration with a compliant nano‐manipulator (CNM). Specifically, the compact CNM provides planar motion with nanoscale precision and millimeter range for the sample, while the probe of the ULSS‐AFM interacts with the sample. Experimental results show that the proposed ULSS‐AFM performs effectively in different scanning ranges under various scanning modes, resolutions, and frequencies. Compared with the conventional AFMs, the approach enables high‐throughput characterization of ultra‐large scale samples without stitching or bow errors, expanding the scanning area of conventional AFMs by two orders of magnitude. This advancement opens up important avenues for cross‐scale scientific research and industrial applications in nano‐ and microscale.
Superior Rate Capability of Small Regenerated Graphite Particles Induced by Homogeneously Distributed Current Density Derived from Cracks and Intrinsic Defects
Authors: Da Haoran , Fang Wenhao , Zhu Jiufu , Li Jin , Pan Shanshan , Li Jiajia , Huang Jiaqi , Zhang Haitao , Zhang Suojiang 
Published: August 2023

AbstractAs spent batteries can be considered as alternative raw sources of electrode materials; the development of regeneration techniques for spent graphite becomes key to realizing economic and environmental sustainability. Herein, the reutilization of small spent graphite particles is domonstrated due to their special structural characteristics, which may directly contribute to the improvement of lithiation kinetics and high‐rate charging during long‐term cycling. Such intrinsic defects and external cracked channels may be introduced by the aging of intrinsic bulk structure and exfoliation of surface structure. On account of these potential advantages, a carbonized polypyrrole layer on sieved small graphite particles is developed to obtain superior rate performance. The coated amorphous/graphitic layer could repair the exposed edge and basal plane, and significantly facilitate Li ion diffusion during fast charging. Moreover, the enhanced performance may favor the improved homogeneity of current density distribution during fast charging, which is confirmed by a porous electrode model. The regenerated graphite with a disorder/order coating layer could effectively regulate the Li+ transport channel, exhibiting a high specific capacity at high‐rate charging (102.7 mAh g−1 at 4 C after 500 cycles) without severe Li plating. This work provides an opportunity to utilize spent graphite in fast‐charging batteries.
Designing a Dimension Reduced Hybrid Perovskite with Robust Large Birefringence by Expanding Cationic π‐Delocation
Authors: Xu Qianting , Huang Weiqi , Wang Han , Li Yanqiang , Zhou Yang , Hou Linxi , Zhao Sangen , Luo Junhua 
Published: August 2023

AbstractIt is in great demand to discover new materials with large birefringence for the miniaturization of optical communication devices. In this work, a new one‐dimensional hybrid halide perovskite, (C6N10H8)Pb2Br6, is obtained successfully through structural design of dimension reduction from the notable three‐dimensional halide perovskite CsPbBr3. Remarkably, (C6N10H8)Pb2Br6 exhibits a significantly enhanced birefringence of ∆n = 0.42@550 nm, which is the largest among halide perovskites so far. Furthermore, its birefringence performance is robust in a wide temperature range of 300–440 K. Theoretical calculations reveal that this outstanding birefringence results from the synergistic effect of [PbBr6]4− octahedra and [C6N10H8]2+ cations with expanding π‐delocation. According to further structural analyses, the structural dimension reduction cooperating with the increase of [PbBr6]4− octahedral distortion leads to the enhanced birefringence. This work uncovers the great promise of hybrid halide perovskites as robust birefringent crystals in future optical communication and would shed useful insights on the design and synthesis of new birefringent crystals.
The effect of the degree of cracking on the state of stress and cracks width in elements with restrained boundary conditions
Authors: Zych Mariusz 
Published: August 2023

AbstractA new and more precise model of cracking of reinforced concrete elements subjected to imposed strains is presented. A key question is how in the stress classic approach to take account of the effect of element relaxation (after each cracking episode) on cracks width reduction and other cracking criteria. Such a model would enable the calculation of the maximum cracks width depending on the cracking stage (i.e., the stage of cracks formation or that of stabilized cracks). This phenomenon is important particularly in semi‐massive structures in which the condition of watertightness must be fulfilled. The model has been validated based on the experimental studies available in the literature. For higher levels of strain the cracks widths have been found seriously underestimated after European standards (especially in elements with higher reinforcement ratio) while the calculations performed following the proposed model indicate proper estimation of cracks width.
Principle active metabolites of Pinus morrisonicolaHayata synergistically inhibit cell proliferation and autophagy to elevate apoptosis in hepatocellular carcinoma cells
Authors: Shibu Marthandam Asokan , Chen Yi‐Ju , Yang Hong‐Siang , He Yen‐Hua , Lo Yun‐Hsin , Lin Wan‐Teng 
Published: August 2023

AbstractHepatocellular carcinoma (HCC), a common primary tumor of liver is a leading cause of cancer‐associated deaths. Improving cellular apoptosis and enhancing autophagic clearance is been considered to improve treatment outcomes of HCC. Polyphenols from Pinus morrisonicola (Hayata) have shown various physiological and therapeutic benefits and the flavonoid chrysin is been known for their anticancer effects. However, the main bioactive principle and the mechanism underlying the antitumor activity of pine needle extract are not clear yet. In this study, the effects of ethanol extract from pine needle on HCC cells were determined. The results show that when compared with administration of chrysin alone, a fraction containing pinocembrin, chrysin, and tiliroside significantly reduced autophagy and increased apoptosis. The results also correlated with decrease in cell cycle regulators and the autophagic proteins like LC3‐II. Collectively, the results imply the fraction containing pinocembrin, chrysin, and tiliroside as an ideal complementary medicine for an effective antitumor activity.
Ferulic acid grafted into β‐cyclodextrin nanosponges amelioratesParaquat‐inducedhumanMRC‐5 fibroblast injury
Authors: Meamar Rokhsareh , Haddad Shadi , Nasiri Rozita , Borojeni Gelare Sadeghi , Kolahdoozan Majid , Eizadi‐Mood Nastaran , Pourisfahani Seyed Alireza , Mahvari Razieh , Rezaei Atefe , Fesharaki Mehrafarin 
Published: August 2023

AbstractParaquat (PQ) is a commercially important and effective herbicide in the world. Nevertheless, it has higher toxicity causing acute organ damage and different complications, mainly in the lungs and kidneys. Ferulic acid (FA), 4‐hydroxy‐3‐methoxycinnamic acid imposes multiple pharmacological impacts. No protective effect of FA on PQ poisoning‐caused human embryonic lung fibroblast damage has not been reported. Despite their many beneficial effects, FA is characterized by poor water solubility, low bioavailability, and phytochemical instability. To solve the problem, β‐cyclodextrin nanosponge (β‐CD NSs) was utilized to increase the solubility of FA so that it was grafted into β‐CD NSs to establish β‐CD@FA NSs. The purpose of this work was to examine for the first time the protective effect of β‐CD@FA NS on MRC‐5 human lung cells damages induced by PQ poisoning. MTS assay was performed to investigate the viability of MRC‐5 cells at different concentrations of FA/β‐CD@FA NSs when cells were co‐cultured with 0.2 μg/mL PQ. The flow cytometry study was carried out to determine apoptosis. Malondialdehyde (MDA), superoxide dismutase (SOD), and catalase (CAT) levels were detected using appropriate biochemistry kits. Compared with the PQ group, the cell activity, CAT, and SOD levels were significantly increased in the FA and chiefly in β‐CD@FA NSs intervention groups, whereas apoptosis and MDA levels were markedly decreased. The inflammatory factors tumor necrosis factor‐alpha (TNF‐α), interleukin 6 (IL‐6), and interleukin 22 (IL‐22) were detected. The results demonstrate that β‐CD@FA NSs can inhibit PQ‐induced cell damage by enhancing antioxidant stress capacity and regulation of inflammatory responses.
The Struggle to Save the JCPOA: Negotiations to Nowhere?
Authors: Miller Steven E. 
Published: August 2023

AbstractOn May 8, 2018, President Donald Trump announced that he was withdrawing the United States from the Joint Comprehensive Plan of Action (JCPOA). However, he failed in his subsequent efforts to coerce Iran into capitulation on the nuclear issue or to accept what Washington regarded as a better deal. The Biden Administration thus inherited a situation in which neither the United States nor Iran was complying with the deal but the Administration was pledged to restore the JCPOA. Rather than simply reverse Trump’s unilateral policy on the JCPOA, though, Biden launched a diplomatic effort aimed at restoring the agreement while possibly modifying some of its terms to address concerns about Tehran's nuclear progress that had arisen when Iran too began to ignore JCPOA constraints. The ensuing negotiations soon bogged down, impeded by a tangle of misaligned perceptions and irreconcilable positions. Washington hoped that the leverage provided by Trump’s sanctions would give Iran incentives to rejoin the agreement, but this perspective failed to take into account that Tehran has its own complaints and reservations about the JCPOA as well as its own internal opposition to the agreement. As a result, more than two years into his Presidency, Biden has been unable to correct what he regarded as the “gigantic mistake” of withdrawing from the JCPOA.