bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efektifitas Perpres No 35/208 untuk Mepercepat Pembangun PLTSa di Indonesia
Authors: Sudrajat Adang , - Syafrudin , Kusdiyantini Endang 
Published: September 2023

Progres pembangunan Pembangkit Listrik Tenaga Sampah (PLTSa) di Indonesia sampai saat ini tidak terlalu signikan, padahal sudah banyak peraturan yang diterbitkan untuk mendukung percepatannya termasuk Peraturan Presiden RI yang diterbitkan beruntun, termasuk yang terakhir nomor 35 tahun 2018 untuk percepatan pembangunan PLTSa di 12 kota besar yang volume sampahnya rata-rata sudah melebihi 1000 MT/hari. Sampai saat ini, baru PLTSa Benowo di Surabaya yang sudah sukses dibangun dan beroperasi secara komersial, sementara yang lainnya masih dalam tahap konstruksi 2 lokasi dan sisanya masih dalam proses perencanaan pengadaan dan penysunsan studi kelayakan. Mengapa pembangunan PLTSa ini berjalan sangat lambat, padahal tariff listrik yang dijual kepada PLN sudah ditetapkan jauh diatas tariff listrik PLN yang dijual kepada pelanggannya? Sudah banyak dilakukan penelitian terkait kendala dalam pembangunan PLTSa ini namun sampai saat ini belum memberikan dampak signifikan terhadap pelaksanaan pembangunannya. Mungkin masih banyak risiko yang harus dihadapi oleh Pemerintah Daerah, Pengembang maupun PLN dan belum ada mitigasi yang dalam kendali mereka sehingga mereka ‘enggan’ untuk aktif dalam proses pembangunan PLTSa ini. Untuk itu dilakukan kajian risiko terhadap pasal-pasal dalam Peraturan Presiden nomor 35 tahun 2018 untuk mengalwali proses penelitian ini, kemudian dilakukan konfirmasi melalui pertanyaan yang dituangkan dalam kuisioner kepada Pemerintah Daerah, Pengembang dan PLN. Setelah dilakukan Analisa data hasil penelitian yang sudah divalidasi, disimpulkan kendala terhambatnya pembangunan PLTSa dimaksud dan disiapkan saran untuk mengatasi kendalanya
Analisis Perkiraan Kebutuhan Energi Sektor Rumah Tangga dengan Skenario BAU (Business As Usual) Menggunakan Perangkat Lunak LEAP (Low Emission Analysis Platform) di Provinsi Sumatera Selatan
Authors: Alqurni Wais , Hadiyanto Hadiyanto 
Published: September 2023

Berdasarkan kebutuhan energi final pertahun yang mengalami peningkatan pada sektor rumah tangga perlu dikaji lebih dalam. Pengkajian ini bertujuan untuk memastikan pasokan energi primer aman dalam jangka panjang selama periode 2022-2040, dengan laju pertumbuhan penduduk sebesar 1,32 % per tahun. Dampak dari pertumbuhan penduduk mengakibatkan total kebutuhan energi final dan primer dalam skenario BAU meningkat. Total kebutuhan energi final sektor rumah tangga meningkat dari 3,8 Juta SBM pada tahun 2021 menjadi 4,9 Juta SBM pada tahun 2040 atau meningkat rata-rata sebesar 5% per tahun. Sedangkan total kebutuhan energi primer yang dibutuhkan di tahun 2022 sebesar 6,1 Juta SBM dan di tahun 2040 sebesar 7,7 Juta SBM atau meningkat rata-rata sebesar 8,42% per tahun. Dalam sektor rumah tangga, energi final meliputi energi listrik dan LPG sedangkan energi primer merupakan energi yang ditransformasikan menjadi energi final ialah berupa gas sumber untuk LPG dan diesel sumber untuk pembangkit listrik tenaga diesel. Dengan demikian, apabila tidak ada kebijakan energi maka sesuai dengan hasil modeling yang dilakukan menggunakan model LEAP untuk skenario BAU dibutuhkan energi final berupa energi listrik dan LPG berturut-turut sebesar 2,5 dan 2,3 juta SBM pada tahun 2040. Sedangkan untuk kebutuhan energi primer gas dan diesel pada tahun yang sama ialah berturut-turut sebesar 2,3 dan 5,4 juta SBM.
Decreased plasma cartilage acidic protein 1 in COVID‐19
Authors: Johansson Mats W. , Balnis Joseph , Muehlbauer Laura K. , Bukhman Yury V. , Stefely Matthew S. , Overmyer Katherine A. , Vancavage Rachel , Tiwari Anupama , Adhikari Anish Raj , Feustel Paul J. , Schwartz Bradford S. , Coon Joshua J. , Stewart Ron , Jaitovich Ariel , Mosher Deane F. 
Published: September 2023

AbstractCartilage acidic protein‐1 (CRTAC1) is produced by several cell types, including Type 2 alveolar epithelial (T2AE) cells that are targeted by SARS‐CoV2. Plasma CRTAC1 is known based on proteomic surveys to be low in patients with severe COVID‐19. Using an ELISA, we found that patients treated for COVID‐19 in an ICU almost uniformly had plasma concentrations of CRTAC1 below those of healthy controls. Magnitude of decrease in CRTAC1 distinguished COVID‐19 from other causes of acute respiratory decompensation and correlated with established metrics of COVID‐19 severity. CRTAC1 concentrations below those of controls were found in some patients a year after hospitalization with COVID‐19, long COVID after less severe COVID‐19, or chronic obstructive pulmonary disease. Decreases in CRTAC1 in severe COVID‐19 correlated (r = 0.37, p = 0.0001) with decreases in CFP (properdin), which interacts with CRTAC1. Thus, decreases of CRTAC1 associated with severe COVID‐19 may result from loss of production by T2AE cells or co‐depletion with CFP. Determination of significance of and reasons behind decreased CRTAC1 concentration in a subset of patients with long COVID will require analysis of roles of preexisting lung disease, impact of prior acute COVID‐19, age, and other confounding variables in a larger number of patients.
Eine andere Art der Bestandspräsentation: Ausstellungen in Bibliotheken
Authors: Lenz Klaudia Charlotte 
Published: September 2023

Zusammenfassung
Ausstellungen sind längst nicht mehr nur in Museen und Kunstgalerien ein diskutiertes und stets weiterzuentwickelndes Thema. Auch in Bibliotheken wird sich dieser Art der Bestandspräsentation und ihrem Nutzen für das Bibliothekspersonal selbst, aber auch für die interessierten Besuchenden angenommen. Ausstellen in Bibliotheken heißt Hürden zu überwinden, weil diese oft neben den eigentlichen Aufgaben im Arbeitsalltag zusätzlich konzipiert und organisiert werden müssen und Bibliothekar*innen per se zunächst keine Ausstellungsexpert*innen sind.
Roundness and slenderness effects on the dynamic characteristics of spar-type floating offshore wind turbine
Authors: Adiputra Ristiyanto , Fauzi Faiz Nur , Firdaus Nurman , Suyanto Eko Marta , Kasharjanto Afian , Puryantini Navik , Erwandi Erwandi , Rasgianti Rasgianti , Prabowo Aditya Rio 
Published: September 2023

Abstract
Spar-type floating offshore wind turbine has been massively developed considering its design simplicity and stability to withstand the wave-induced motion. However, the variation of the local sea level and the readiness of supporting production facilities demand the spar design to adapt in a viable way. Considering this, the present article investigated how the slenderness (length over diameter ratio) and the roundness of cross section influence the hydrodynamic characteristics, which are the crucial parameters of floater performances. The OC3-Hywind spar-type floating platform was adapted as the reference model. The length of the reference floater was then varied with a ratio of 1.5, 2, 2.5, and 3 and the diameter was proportionally scaled to obtain constant buoyancy. The number of the sides which indicated the roundness of the cross section was varied to be 4, 6, 8, 10, 12, 14, and infinity (cylindrical shape). The analysis was conducted using potential flow theory in a boundary element method solver through an open-source code NEMOH. Initially, panel convergence was conducted and compared with the experimental results of the reference model to obtain the appropriate simulation settings before being used for the case configuration analysis. Results stated that the roundness effect with sides greater than 16 had little effect on dynamic characteristics. Meanwhile, the spar with the largest diameter was more stable against the translational motion.
Diagnostic properties of natriuretic peptides and opportunities for personalized thresholds for detecting heart failure in primary care
Authors: Harskamp Ralf E. , De Clercq Lukas , Veelers Lieke , Schut Martijn C. , van Weert Henk C.P.M. , Handoko M. Louis , Moll van Charante Eric P. , Himmelreich Jelle C.L. 
Published: September 2023

Abstract

Objectives
Heart failure (HF) is a prevalent syndrome with considerable disease burden, healthcare utilization and costs. Timely diagnosis is essential to improve outcomes. This study aimed to compare the diagnostic performance of B-type natriuretic peptide (BNP) and N-terminal proBNP (NT-proBNP) in detecting HF in primary care. Our second aim was to explore if personalized thresholds (using age, sex, or other readily available parameters) would further improve diagnostic accuracy over universal thresholds.

Methods
A retrospective study was performed among patients without prior HF who underwent natriuretic peptide (NP) testing in the Amsterdam General Practice Network between January 2011 and December 2021. HF incidence was based on registration out to 90 days after NP testing. Diagnostic accuracy was evaluated with AUROC, sensitivity and specificity based on guideline-recommended thresholds (125 ng/L for NT-proBNP and 35 ng/L for BNP). We used inverse probability of treatment weighting to adjust for confounding.

Results
A total of 15,234 patients underwent NP testing, 6,870 with BNP (4.5 % had HF), and 8,364 with NT-proBNP (5.7 % had HF). NT-proBNP was more accurate than BNP, with an AUROC of 89.9 % (95 % CI: 88.4–91.2) vs. 85.9 % (95 % CI 83.5–88.2), with higher sensitivity (95.3 vs. 89.7 %) and specificity (59.1 vs. 58.0 %). Differentiating NP cut-off by clinical variables modestly improved diagnostic accuracy for BNP and NT-proBNP compared with a universal threshold.

Conclusions
NT-proBNP outperforms BNP for detecting HF in primary care. Personalized instead of universal diagnostic thresholds led to modest improvement.
Finite 𝑝-groups of class two with a small multiple holomorph
Authors: Caranti A. , Tsang Cindy (Sin Yi) 
Published: September 2023

Abstract
We consider the quotient group

T
⁢

(
G
)

T(G)

of the multiple holomorph by the holomorph of a finite 𝑝-group 𝐺 of class two for an odd prime 𝑝.
By work of the first-named author, we know that

T
⁢

(
G
)

T(G)

contains a cyclic subgroup of order

p

r
−
1

⁢

(

p
−
1

)

p^{r-1}(p-1)

, where

p
r

p^{r}

is the exponent of the quotient of 𝐺 by its center.
In this paper, we shall exhibit examples of 𝐺 (with

r
=
1

r=1

) such that

T
⁢

(
G
)

T(G)

has order exactly

p
−
1

p-1

, which is as small as possible.
On the discrete Sobolev inequalities
Authors: Ngwamou Sedrick K. , Ndjinga Michael 
Published: September 2023

Abstract
We prove a discrete version of the famous Sobolev inequalities in ℝ
d
for d ∈ ℕ*, p ∈ [1, +∞[ for general non orthogonal meshes with possibly non convex cells. We follow closely the proof of the continuous Sobolev inequality based on the embedding of BV(ℝ
d
) into L
d/(d–1) by introducing discrete analogs of the directional total variations. In the case p ⩽ d (Gagliardo–Nirenberg inequality), we adapt the proof of the continuous case and use techniques from prior works. In the case p > d (Morrey’s inequality), we simplify and extend the proof of Porreta to more general meshes.
Crystal structure of poly[(μ-benzoato)-(μ-cis-4–hydroxy-D-proline)lithium], C12H14LiNO5
Authors: Yin Dejing , Wang Lingling , Yuan Zhenbo 
Published: September 2023

Abstract
(C12H14LiNO5)n, orthorhombic, P212121 (no. 19), a = 5.1481(4) Å, b = 8.9342(7) Å, c = 25.733(2) Å, Z = 4, V = 1183.57(16) Å3, R
gt(F) = 0.0539, wR
ref(F
2) = 0.1478, T = 100 K.
Biopolymer conjugation with phytochemicals and applications
Authors: Rana Anchal , Bhardwaj Sonal , Sharma Nandita 
Published: September 2023

Abstract
Sustainable and intelligent solutions are required to address the issues brought about by anthropogenic activity and the restricted availability of resources. Every nation is attempting to use each product from a natural resource in a necessary way in light of the current rise in environmental awareness. The bio-based biopolymers can be made from bacteria, animals, or plants. Biopolymers are a diverse class of compounds that are either produced by biological systems or synthesized from biological resources. Biopolymers are categorized as biodegradable and nonbiodegradable. Based on origin, they are further classified as being either bio based or fossil fuel based. Recently, biopolymers have gained immense recognition in different areas of biomedical field such as wound healing, burn dressing, tissue engineering, and fungal infection. These biodegradable polymer composites are effective at containing and releasing bioactive medications, such as probiotics, enzymes, pharmaceuticals, and nutraceuticals. Moreover, medicinal plants, a rich source of phytochemicals have been extensively used for their various therapeutic activities since ancient times and are being steadily providing the basis in modern drug delivery systems. There has been a lot of interest in the detection, separation, and use of dietary phytochemicals that may enhance human health and act as natural pigments, antioxidants, or antimicrobials well-being by preventing chronic illnesses like cancer, diabetes, obesity, and cardiovascular disorders. However, the delivery of these compounds for enhanced efficacy requires a rational approach. Therefore, the present chapter discuss about various sources of biopolymer, challenges, their construction mechanism, and their conjugation with phytochemicals as well as their applications.
How Does Temporal Blurring Alter Movement Timing?
Authors: Drążyk Dominika , Missal Marcus 
Published: September 2023

AbstractSubjective uncertainty arises because the estimation of the timing of an event into the future is error prone. This impact of stimulus-bound uncertainty on movement preparation has often been investigated using reaction time tasks where a warning stimulus (WS) predicts the occurrence of a “go” signal. The timing of the “go” signal can be chosen from a particular probability distribution with a given variance or uncertainty. It has been repeatedly shown that reaction times covary with the shape of the used “go” signal distribution. This is interpreted as evidence for temporal preparation. Moreover, the variance of the response time should always increase with the duration of the delay between the WS and the “go” signal. This increasing variance has been interpreted as a consequence of the temporal “blurring” of future events (scalar expectancy). The present paper tested the validity of the temporal “blurring” hypothesis in humans with a simple oculomotor reaction time task where subjective and stimulus-bound uncertainties were increased. Subjective uncertainty about the timing of a “go” signal was increased by lengthening the delay between the WS and the “go” signal. Objective uncertainty was altered by increasing the variance of “go” signal timing. Contrary to temporal blurring hypotheses, the study has shown that increasing the delay between events did not significantly increase movement timing variability. These results suggest that temporal blurring could not be a property of movement timing in an implicit timing context.
A Novel Head-Fixed Assay for Social Touch in Mice Uncovers Aversive Responses in Two Autism Models
Authors: Chari Trishala , Hernandez Ariana , Portera-Cailliau Carlos 
Published: September 2023

Social touch, an important aspect of social interaction and communication, is essential to kinship across animal species. How animals experience and respond to social touch has not been thoroughly investigated, in part because of the lack of appropriate assays. Previous studies that examined social touch in freely moving rodents lacked the necessary temporal and spatial control over individual touch interactions. We designed a novel head-fixed assay for social touch in mice, in which the experimenter has complete control to elicit highly stereotyped bouts of social touch between two animals. The user determines the number, duration, context, and type of social touch interactions, while monitoring an array of complex behavioral responses with high resolution cameras. We focused on social touch to the face because of its high translational relevance to humans. We validated this assay in two different models of autism spectrum disorder (ASD), theFmr1knock-out (KO) model of Fragile X syndrome (FXS) and maternal immune activation (MIA) mice. We observed higher rates of avoidance running, hyperarousal, and aversive facial expressions (AFEs) to social touch than to object touch, in both ASD models compared with controls.Fmr1KO mice showed more AFEs to mice of the same sex but whether they were stranger or familiar mice mattered less. Because this new social touch assay for head-fixed mice can be used to record neural activity during repeated bouts of social touch it could be used to uncover underlying circuit differences.SIGNIFICANCE STATEMENTSocial touch is important for communication in animals and humans. However, it has not been extensively studied and current assays to measure animals' responses to social touch have limitations. We present a novel head-fixed assay to quantify how mice respond to social facial touch with another mouse. We validated this assay in autism mouse models since autistic individuals exhibit differences in social interaction and touch sensitivity. We find that mouse models of autism exhibit more avoidance, hyperarousal, and aversive facial expressions (AFEs) to social touch compared with controls. Thus, this novel assay can be used to investigate behavioral responses to social touch and the underlying brain mechanisms in rodent models of neurodevelopmental conditions, and to evaluate therapeutic responses in preclinical studies.
Glial Sphingosine-Mediated Epigenetic Regulation Stabilizes Synaptic Function inDrosophilaModels of Alzheimer's Disease
Authors: Yin Pengqi , Cai Yimei , Cui Tao , Berg Andrew J. , Wang Ting , Morency Danielle T. , Paganelli Paxton M. , Lok Chloe , Xue Yang , Vicini Stefano , Wang Tingting 
Published: September 2023

Destabilization of neural activity caused by failures of homeostatic regulation has been hypothesized to drive the progression of Alzheimer's Disease (AD). However, the underpinning mechanisms that connect synaptic homeostasis and the disease etiology are yet to be fully understood. Here, we demonstrated that neuronal overexpression of amyloid β (Aβ) causes abnormal histone acetylation in peripheral glia and completely blocks presynaptic homeostatic potentiation (PHP) at the neuromuscular junction inDrosophila. The synaptic deficits caused by Aβ overexpression in motoneurons are associated with motor function impairment at the adult stage. Moreover, we found that a sphingosine analog drug, Fingolimod, ameliorates synaptic homeostatic plasticity impairment, abnormal glial histone acetylation, and motor behavior defects in the Aβ models. We further demonstrated that perineurial glial sphingosine kinase 2 (Sk2) is not only required for PHP, but also plays a beneficial role in modulating PHP in the Aβ models. Glial overexpression ofSk2rescues PHP, glial histone acetylation, and motor function deficits that are associated with Aβ inDrosophila. Finally, we showed that glial overexpression ofSk2restores PHP and glial histone acetylation in a genetic loss-of-function mutant of the Spt-Ada-Gcn5 Acetyltransferase complex, strongly suggesting thatSk2modulates PHP through epigenetic regulation. Both male and female animals were used in the experiments and analyses in this study. Collectively, we provided genetic evidence demonstrating that abnormal glial epigenetic alterations in Aβ models inDrosophilaare associated with the impairment of PHP and that the sphingosine signaling pathway displays protective activities in stabilizing synaptic physiology.SIGNIFICANCE STATEMENTFingolimod, an oral drug to treat multiple sclerosis, is phosphorylated by sphingosine kinases to generate its active form. It is known that Fingolimod enhances the cognitive function in mouse models of Alzheimer's disease (AD), but the role of sphingosine kinases in AD is not clear. We bridge this knowledge gap by demonstrating the relationship between impaired homeostatic plasticity and AD. We show that sphingosine kinase 2 (Sk2) in glial cells is necessary for homeostatic plasticity and that glialSk2-mediated epigenetic signaling has a protective role in synapse stabilization. Our findings demonstrate the potential of the glial sphingosine signaling as a key player in glia–neuron interactions during homeostatic plasticity, suggesting it could be a promising target for sustaining synaptic function in AD.
RISING STARS: Role of MED12 mutation in the pathogenesis of uterine fibroids
Authors: Ishikawa Hiroshi , Kobayashi Tatsuya , Kaneko Meika , Saito Yoshiko , Shozu Makio , Koga Kaori 
Published: September 2023

Graphical abstract

Abstract
Uterine fibroids (UFs) are benign tumors arising from the uterus, characterized by accumulation of abundant extracellular matrix (ECM) and sex steroid-dependent growth. Women with symptomatic UFs have reduced quality of life and decreased labor productivity. Among the driver gene mutations identified in UFs, mutations in MED12, a component of the cyclin-dependent kinase (CDK) Mediator module, are the most common and observed in 50–80% of UFs. They are gain-of-function mutations and are more frequently observed in Black women and commonly observed even in small UFs. MED12 mutation-positive UFs (MED12-UFs) often develop multiple rather than solitary and have distinct gene expression profiles, DNA methylomes, transcriptomes, and proteomes. Gene expressions related to ECM organization and collagen-rich ECM components are upregulated, and impaired Mediator kinase activity and dysregulation of Wnt/β-catenin signaling are identified in MED12-UFs. Clinically, the UF shrinking effect of gonadotropin-releasing hormone agonists and ulipristal acetate is dependent on the MED12 mutation status. Understanding of characteristics of MED12-UFs and functions of MED12 mutations for UF tumorigenesis may elucidate the pathophysiology of UFs, leading to the development of new therapeutic options in women with symptomatic UFs.