bluuebunny/crossref_metadata_2025_split huggingface dataset:
Immunoregulation by resveratrol; implications for normal tissue protection and tumour suppression
Authors: Lalani Armineh Rezagholi , Fakhari Fatemeh , Radgoudarzi Shakila , Rastegar‐Pouyani Nima , Moloudi Kave , Khodamoradi Ehsan , Taeb Shahram , Najafi Masoud 
Published: February 2023

AbstractImmune reactions are involved in both tumour and normal tissue in response to therapy. Elevated secretion of certain chemokines, exosomes and cytokines triggers inflammation, pain, fibrosis and ulceration among other normal tissue side effects. On the other hand, secretion of tumour‐promoting molecules suppresses activity of anticancer immune cells and facilitates the proliferation of malignant cells. Novel anticancer drugs such as immune checkpoint inhibitors (ICIs) boost anticancer immunity via inducing the proliferation of anticancer cells such as natural killer (NK) cells and CD8+ T lymphocytes. Certain chemotherapy drugs and radiotherapy may induce anticancer immunity in the tumour, however, both have severe side effects for normal tissues through stimulation of several immune responses. Thus, administration of natural products with low side effects may be a promising approach to modulate the immune system in both tumour and normal organs. Resveratrol is a well‐known phenol with diverse effects on normal tissues and tumours. To date, a large number of experiments have confirmed the potential of resveratrol as an anticancer adjuvant. This review focuses on ensuing stimulation or suppression of immune responses in both tumour and normal tissue after radiotherapy or anticancer drugs. Later on, the immunoregulatory effects of resveratrol in both tumour and normal tissue following exposure to anticancer agents will be discussed.
Catastrophe theory and economic modelling at the back of an envelope
Authors: Pol Eduardo 
Published: February 2023

AbstractCatastrophe theory (CT) emerged out of problems in pure mathematics. The insights and language of differential topology, from which CT sprang, are foreign to most economists. The purpose of this paper is to explain how to use Abstract CT in economic modelling. To this end, we spell out a step‐by‐step procedure that can be understood without a knowledge of differential topology. The corollary advantage of our systematic procedure is that it brings into sharp focus the limited relevance of CT for economic modelling. The paper is developed in four stages. The first stage provides a gentle introduction to the key mathematical concepts for readers new to CT. The second stage consists of a brief description of the structure of economic modelling. In the third stage, a procedure about how to use CT in economic modelling is spelled out. The last stage summarises the main ideas of CT and points out the snags that a modeller will inevitably encounter when applying CT to economics.
The Economic Impacts of the COVID‐19 Pandemic in Australia: A Closer Look at Gender Gaps in Employment, Earnings and Education
Authors: Risse Leonora 
Published: February 2023

AbstractThree years into the COVID‐19 pandemic, this article considers the longer‐lasting economic impacts on the Australian workforce through a gender lens. Using Australian Bureau of Statistics data, it analyses changes in employment, earnings and educational participation relative to the pre‐pandemic trends that were predicted to have otherwise occurred. Despite women's employment moving back towards pre‐pandemic levels more rapidly than men's, the pandemic also saw a widening of the gender gap in earnings and a larger fall in women's educational participation. This paper highlights the need for ongoing monitoring of labour market indicators through a gender lens to inform more responsive policy design.
Characterization of the interaction between boscalid and tannic acid and its effect on the antioxidant properties of tannic acid
Authors: Fu Xiaoyan , Yuan Shaofeng , Yang Fangwei , Yu Hang , Xie Yunfei , Guo Yahui , Yao Weirong 
Published: February 2023

AbstractThe binding of pesticide residues and fruit components may have a profound impact on pesticide dissipation and the functional characteristics of the corresponding components. Therefore, the interaction between boscalid and tannic acid (TA, a representative phenolic in fruit) was systematically investigated using spectroscopic, thermodynamic, and computational chemistry methods. A separable system was designed to obtain the boscalid–TA complex. Fourier transform infrared and 1H‐NMR spectroscopies indicated the formation of hydrogen bonds in the complex. Isothermal titration calorimetry showed that the complex bound spontaneously through hydrophobic interactions (ΔG < 0, ΔH > 0, ΔS > 0), with a binding constant of 6.0 × 105 M−1 at 298 K. The molecular docking results further confirmed the formation of hydrogen bonds and hydrophobic interactions in the complex at the molecular level, with a binding energy of −8.43 kcal mol−1. In addition, the binding of boscalid to TA significantly decreased the antioxidant activity of TA. The binding of boscalid residue to TA was characterized at the molecular level, which significantly reduced the in vitro antioxidant properties of TA.Practical ApplicationThis study provides a reference for the molecular mechanisms of the interaction between pesticide residues and food matrices, as well as a basis for regulating bound‐state pesticide residues in food.
Editorial: considerations for expanding treatment in grey zone chronic hepatitis B patients
Authors: Liu Yen‐Chun , Jeng Wen‐Juei 
Published: February 2023

LINKED CONTENTThis article is linked to Wang et al papers. To view these articles, visit https://doi.org/10.1111/apt.17272 and https://doi.org/10.1111/apt.17369
Who is my family?: A comparative study of the family boundary in East Asia
Authors: Eun Suk , An Seung Jae 
Published: February 2023

AbstractMost Asian countries are regarded as Confucian countries although each has its own historical and cultural background. Little is known about how people in different Asian countries perceive their family boundaries. This study is an attempt to compare the perception of the family in China, Japan, and Korea. We examined the family perception and found substantial differences among the three. Chinese people showed the widest and paternally extended perception of family. Data from people in Korea nearly matched data from China, but family perception developed bilaterally. People in Japan, however, perceived only blood‐tied, intimate relations as family members. In addition, the perception of the family was not substantially different between the genders in Japan and China, but in South Korea, men perceived family boundaries more widely than women, implying that women have a greater family burden than men in Korea. Considering the heterogeneity in family perceptions in these countries, this paper tries to explain how social institutions interact with individuals and impact the perception of family. Finally, this paper concludes that it is inappropriate to tie the three East Asian countries as ‘Confucian civilizations’ in terms of family perception.
SOCS3 deregulation contributes to aberrant activation of the JAK/STAT pathway in precursor T‐cell neoplasms
Authors: Lahera Antonio , López‐Nieva Pilar , Alarcón Hernán , Marín‐Rubio José L. , Cobos‐Fernández María Á. , Fernández‐Navarro Pablo , Fernández Agustín F. , Vela‐Martín Laura , Sastre Isabel , Ruiz‐García Sara , Llamas Pilar , López‐Lorenzo José L. , Cornago Javier , Santos Javier , Fernández‐Piqueras José , Villa‐Morales María 
Published: February 2023

SummaryDespite the Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway being frequently altered in T‐ALL/LBL, no specific therapy has been approved for T‐ALL/LBL patients with constitutive signalling by JAK/STAT, so there is an urgent need to identify pathway members that may be potential therapeutic targets. In the present study, we searched for JAK/STAT pathway members potentially modulated through aberrant methylation and identified SOCS3 hypermethylation as a recurrent event in T‐ALL/LBL. Additionally, we explored the implications of SOCS3 deregulation in T‐ALL/LBL and demonstrated that SOCS3 counteracts the constitutive activation of the JAK/STAT pathway through different molecular mechanisms. Therefore, SOCS3 emerges as a potential therapeutic target in T‐ALL/LBL.
Screening diagnosis of executive dysfunction after ischemic stroke and the effects of transcranial magnetic stimulation: A prospective functional near‐infrared spectroscopy study
Authors: Liu Yuanwen , Luo Jing , Fang Jie , Yin Mingyu , Cao Jie , Zhang Shuxian , Huang Li , Cheng Qilin , Ai Yinan , Zheng Haiqing , Hu Xiquan 
Published: February 2023

AbstractBackgroundPost‐ischemic stroke executive impairment (PISEI) is a serious obstacle for patients to returning to their society and is currently difficult to screen early and clinically ineffective.AimThe aim of the study was to clarify whether functional near‐infrared spectroscopy (fNIRS) can be used as a rapid screening tool for PISEI and to explore the efficacy of transcranial magnetic stimulation (TMS) in PISEI patients and the changes in brain function.MethodsA single‐blind, randomized controlled study design was used to detect hemodynamic differences by fNIIRS in 16 PISEI patients and 16 healthy subjects during the resting state and Stroop task, respectively. After 3 days, all subjects received a single TMS intervention and underwent simultaneous fNIRS testing for the Stroop task before and 3 days after the TMS intervention.ResultsPISEI patients had significantly higher HbO2 content in the left dorsolateral prefrontal cortex (DLPFC), the right pre‐motor cortex (PMC) and the right primary sensorimotor cortex (SM1) during the Stroop task compared to the resting state (F = 141.966, p < 0.001), but significantly lower than healthy subjects (T = −3.413, p = 0.002). After TMS intervention, PISEI patients' time and error number scores on the Stroop test were significantly enhanced, and the functional activity of the above‐mentioned brain regions was significantly more active than at baseline, while the strength of their functional connections with each other was markedly increased.ConclusionsfNIRS helped screen and diagnose PISEI. A single TMS session benefited PISEI patients with effects lasting 3 days, which may be attributed to activation of the left DLPFC, right PMC and right SM1 brain regions.
User‐perceived impact of long‐term mechanical assisted cough in paediatric neurodisability
Authors: Hov Brit , Andersen Tiina , Toussaint Michel , Mikalsen Ingvild B. , Vollsæter Maria , Markussen Heidi , Indrekvam Solfrid , Hovland Vegard 
Published: February 2023

AbstractAimTo (1) compare the perceived benefit of long‐term mechanical insufflation‐exsufflation (MI‐E) of children with neuromuscular disorders (NMDs) and central nervous system (CNS) disorders, including health care needs and treatment routines and (2) describe the children's health‐related quality of life (HRQoL).MethodThis cross‐sectional study used a questionnaire and memory card data to assess the perceived benefit of MI‐E via the Visual Analogue Scale (VAS; 10 maximum), willingness to pause treatment, level of health care needs before and after MI‐E initiation, and the children's treatment routines. A DISABKIDS questionnaire assessed HRQoL (100 maximum).ResultsSeventy‐three children using MI‐E participated (42 males, median [interquartile range {IQR}] age 10 years 2 months [6 years 3 months–14 years 1 month]), 47 with NMDs (such as spinal muscular atrophy and Duchenne muscular dystrophy) and 26 with CNS disorders (such as cerebral palsy, encephalitis, neurometabolic and other diseases). The median (IQR) VAS score for the perceived benefit of MI‐E therapy at stable state and respiratory tract infection were 9 (6–10) and 10 (8.5–10) respectively. Sixty‐two per cent were reluctant or unwilling to pause MI‐E therapy, with no NMD versus CNS disorder group difference. After MI‐E initiation, fewer physician consultations and hospitalizations were reported by the group with NMDs. The MI‐E routine was similar in both groups. The mean (SD) HRQoL score for 26 of 51 eligible children was 71 (16.7).InterpretationMI‐E treatment was generally perceived as beneficial and performed equally in both diagnostic groups. HRQoL was in line with children with a moderate‐to‐severe chronic condition.What this paper adds

Mechanical insufflation‐exsufflation (MI‐E) was generally perceived as beneficial by the children and parents.
The reported benefit of MI‐E was higher among daily than sporadic MI‐E users.
The MI‐E treatment routine did not differ between diagnostic groups.
The health‐related quality of life in this neuropaediatric population was in line with that of children with other moderate‐to‐severe chronic conditions.
Efficacy and safety of sotagliflozin in patients with type 2 diabetes and stage 3 chronic kidney disease
Authors: Cherney David Z. I. , Ferrannini Ele , Umpierrez Guillermo E. , Peters Anne L. , Rosenstock Julio , Powell David R. , Davies Michael J. , Banks Phillip , Agarwal Rajiv 
Published: February 2023

AbstractAimTo assess the efficacy and safety of sotagliflozin, a dual inhibitor of sodium‐glucose co‐transporters 1 and 2, in adults with type 2 diabetes (T2D) and stage 3 chronic kidney disease (CKD3).Materials and MethodsThis phase 3, randomized, placebo‐controlled trial evaluated sotagliflozin 200 and 400 mg in 787 patients with T2D and an estimated glomerular filtration rate of 30‐59 ml/min/1.73m2. The primary objective was superiority of week 26 HbA1c reductions with sotagliflozin versus placebo. Secondary endpoints included changes in other glycaemic and renal endpoints overall and in CKD3 subgroups.ResultsAt 26 weeks, the placebo‐adjusted mean change in HbA1c (from a baseline of 8.3% ± 1.0%) was –0.1% (95% CI: –0.2% to 0.05%; P = .2095) and –0.2% (–0.4% to –0.09%; P = .0021) in the sotagliflozin 200 and 400 mg groups, respectively. Significant reductions in fasting plasma glucose and body weight, but not systolic blood pressure, were observed. Among patients with at least A2 albuminuria at week 26, the urine albumin‐creatinine ratio (UACR) was reduced with both sotagliflozin doses relative to placebo. At week 52, UACR was reduced with sotagliflozin 200 mg in the CKD3B group. Adverse events (AEs), including serious AEs, were similar between the treatment groups.ConclusionsAfter 26 weeks, HbA1c was significantly reduced with sotagliflozin 400 but not 200 mg compared with placebo in this CKD3 cohort. UACR in patients with at least A2 albuminuria was reduced with each of the two doses at 26 weeks, but changes were not sustained at week 52. The safety findings were consistent with previous reports (NCT03242252).
Structure‐preserving transformations of epistemic models
Authors: Bach Christian W. , Perea Andrés 
Published: February 2023

AbstractThe prevailing approaches to modeling interactive uncertainty with epistemic models in economics are state‐based and type‐based. We explicitly formulate two general procedures that transform state models into type models and vice versa. Both transformation procedures preserve the belief hierarchies as well as the common prior assumption. By means of counterexamples it is shown that our procedures are not inverse to each other. However, if attention is restricted to maximally reduced epistemic models, then isomorphisms can be constructed and an inverse relationship emerges.
State ownership and zombie firms: Evidence from China's 2008 stimulus plan
Authors: Li Jiani , Li Jie , Zhou Tianhang 
Published: February 2023

AbstractWhether and how are zombie firms associated with a crisis‐rescue plan? We examine this issue through the channel of state‐owned enterprises (SOEs). We find that, after China's 2008 stimulus plan, a firm in the city with a high SOE share is more likely to become a zombie firm. This result may be driven by the fact that government‐led investment, through SOEs, tends to focus more on employment‐related projects than efficient ones, particularly during the crisis period. Resource misallocation associated with the crisis‐rescue plan may cause production inefficiency, which leads to the emergence of zombie firms.
Transcriptomic profiling of castes and of sexually and parthenogenetically produced reproductive females in the termite Cavitermes tuberosus
Authors: de Souza Araujo Natalia , Hellemans Simon , Roisin Yves , Fournier Denis 
Published: February 2023

AbstractIn termites with a true worker caste, the development pattern splits up from early developmental stages: primary reproductives develop through the nymphal line, whereas workers and soldiers follow the apterous developmental line. In some species, such as Cavitermes tuberosus Emerson (Isoptera: Termitidae, Termitinae), secondary reproductives (or neotenics) may also develop through the nymphal line from a transitional stage called aspirant. Aspirants originate mostly from automictic parthenogenetic reproduction. Therefore, C. tuberosus queens originate from sexual (primary queens) or parthenogenetic (neotenic queens) reproduction. A comparison of these two queen castes offers the possibility to better understand core molecular underpinnings of caste development and plasticity in termites. We investigated these molecular mechanisms by using high‐throughput Illumina RNA sequencing of pooled individuals. We first assembled the de novo reference transcriptome of C. tuberosus, and then identified the transcripts consistently co‐expressed across castes, sexes, and two alternative routes to female reproduction. Cavitermes tuberosus final transcriptome had 130 874 transcripts, N50 of 3398, and total length of 213 549 184 bp. We found that female reproductive maturation was characterized by gene expression down‐regulation: primary queens expressed fewer transcripts overall and had the greatest number of down‐regulated transcripts when compared to all other castes. In both secondary and primary queens, biological processes involved in muscle development and contraction, flight, and olfactory learning were enriched in the down‐regulated gene cluster. In contrast, processes related to reproductive development, insulin receptor signaling pathway, isoprenoid biosynthesis, and multiple metabolic processes were enriched among up‐regulated genes in primary queens. Finally, we found that 17% of all transcripts (21852) were differently co‐expressed when females from sexual and parthenogenetic origins were compared, even though the expression profile of core reproductive‐related gene clusters showed a similar trend in all reproductive females despite their origin. Our findings fit the genomic imprinting model predictions of a maternal effect that commonly regulates the expression of core reproductive genes in females from parthenogenetic and non‐parthenogenetic origins, whereas the expression of non‐reproductive genes varies.
Population growth and behavioural interactions of a critically endangered fish with co‐occurring native and exotic species
Authors: Suárez‐Rodríguez M. , del‐Val E. , Domínguez‐Domínguez O. , Ojanguren A. F. , Camacho‐Cervantes M. 
Published: February 2023

Abstract

Invasive species represent a threat to biodiversity and ecosystem services and cost millions of dollars to the global economy. The viviparous Mexican fish known as the tequila splitfin (Zoogoneticus tequila) became extinct in the wild as a consequence of habitat loss and degradation, and interactions with invasive species. Tequila splitfins are native to the Teuchitlan River in Central Mexico; they were kept in captivity and reintroduced into their native distribution in 2016. Approximately 80% of the fish in the Teuchitlan River are exotic species, and over 50% are twospot livebearers (Pseudoxiphophorus bimaculatus).

We performed an ex‐situ mesocosm experiment to explore whether tequila splitfin populations would establish and increase, and how fish would behave when introduced into sites already colonised by other species. We tested this idea by introducing tequila splitfin individuals into empty mesocosms, mesocosms where individuals of the native Ameca splendens had established, mesocosms with individuals of the native Goodea atripinnis and mesocosms with individuals of exotic invasive twospot livebearers. All heterospecific species have been recorded in tequila splitfin's native range, are viviparous fish and share ecological requirements with them.

We found that tequila splitfin abundance (number of individuals that survived and new individuals) was greater when sharing mesocosms with native species. Furthermore, they had reduced activity levels when inhabiting mesocosms with exotic invasive twospot livebearers, in comparison, interactions with natives proved to be beneficial.

Our results highlight the need to remove exotic invasive species and protect other native species to increase reintroduction success. Close monitoring is needed during the initial stages of the reintroduction, and several reintroduction events from captive breeding facilities may also be necessary. When planning a reintroduction, it is critical to remove exotic species and make an effort to restore the habitat as close as possible to the original conditions.
Identification of candidate genes for nicotine withdrawal in C57BL/6J × DBA/2J recombinant inbred mice
Authors: Smith Maren L. , Mignogna Kristin M. , Rokita Jo L. , MacLeod Lorna , Damaj M. Imad , Miles Michael F. 
Published: February 2023

AbstractNicotine is the reinforcing ingredient in tobacco. Following chronic exposure, sudden cessation of nicotine use produces negative symptoms of withdrawal that contribute to dependence. The molecular mechanisms underlying nicotine withdrawal behaviors, however, are poorly understood. Using recombinant inbred mice, chronic nicotine was delivered by minipump and withdrawal induced using mecamylamine. Somatic signs of withdrawal, and anxiety‐like behavior using elevated plus maze, were then assessed. Interval mapping was used to identify associations between genetic variation and withdrawal behaviors, and with basal gene expression. Differential gene expression following nicotine exposure and withdrawal was also assessed in progenitor mice using microarrays. Quantitative trait loci mapping identified chromosome intervals with significant genetic associations to somatic signs of withdrawal or withdrawal‐induced anxiety‐like behavior. Using bioinformatics, and association with basal gene expression in nucleus accumbens, we implicated Rb1, Bnip3l, Pnma2, Itm2b, and Kif13b as candidate genes for somatic signs of withdrawal, and Galr1, which showed trans‐regulation from a region of chromosome 14 that was associated with somatic signs of withdrawal. Candidate genes within the chromosome 9 region associated with anxiety‐like withdrawal behavior included Dixdc1, Ncam1, and Sorl1. Bioinformatics identified six genes that were also significantly associated with nicotine or alcohol traits in recent human genome‐wide association studies. Withdrawal‐associated somatic signs and anxiety‐like behavior had strong non‐overlapping genetic associations, respectively, with regions of chromosome 14 and chromosome 9. Genetic, behavioral and gene expression correlations, and bioinformatics analysis identified several candidate genes that may represent novel molecular targets for modulating nicotine withdrawal symptoms.