bluuebunny/crossref_metadata_2025_split huggingface dataset:
Occurrences of tropical, subtropical and rare marine fishes in Aotearoa New Zealand indicate biodiversity change
Authors: Middleton Irene , Francis Malcolm , Aguirre J. David , Struthers Carl , Trnski Thomas , Duffy Clinton , Anderson John , Carney Mary , Cox Nathan , Hemstalk Stephen , Herbert Blair , Johnston Craig , Middleton Crispin , Oldfield Tim , Robinson Richard , Sheath Chris , Skipworth Ian , Stancich Jakson , Whittington Hope , Liggins Libby 
Published: June 2023

AbstractAimClimate change is driving biogeographic change globally, including poleward range shifts of species and the increasing abundance of rare species. We examine spatiotemporal patterns in the occurrences of tropical, subtropical and rare marine fishes in Aotearoa New Zealand to determine whether biodiversity change is occurring in this temperate region and to set a baseline for future monitoring of climate change impacts.LocationAotearoa New Zealand (NZ).TaxonMarine fishes.MethodsWe consolidated 100 years of unpublished records and citizen science sightings of tropical, subtropical and rare fishes to develop a focal species database for NZ. Using hotspot analysis, we identified geographic locations where the occurrence and diversity of focal species is greater than expected. We examine the spatiotemporal variation in hotspots by focal species lifestage, habitat and taxonomic family.ResultsFocal species occurrences and diversity in NZ have increased. We present 17 new‐to‐NZ marine fish species, and a new‐to‐NZ family. Focal species now account for 6.5% of pelagic fishes and 17.3% of benthic fishes in NZ. The northeast of the North Island (Te Ika‐a‐Māui) was a consistent hotspot of focal species occurrences and diversity. Hotspots of mature and pelagic fish occurrences appeared further south than juvenile and benthic species occurrences. Families with tropical affinities (Labridae and Pomacentridae) were restricted to northeastern NZ whereas hotspots of families with temperate affinities (i.e. Cheilodactylidae) extended into the South Island (Te Waipounamu).Main ConclusionsTropical, subtropical and rare fishes are a major component of the fish biodiversity in temperate NZ, and their occurrences and diversity has increased over the past half‐century. Northeastern NZ consistently has the highest occurrence rate and diversity of warmer‐water fishes. Our study demonstrates the value in consolidating citizen scientist observations to detect biodiversity change, and to inform current baselines and future monitoring of climate‐related biodiversity change.
Erroneous electrocardiographic interpretations and its clinical implications
Authors: Shaik Ayesha , Patel Nirav , Alvarez Chikezie , Panza Gregory , Baker William L. , McMahon Sean , Kluger Jeffrey 
Published: June 2023

AbstractIntroductionThe advancement of artificial intelligence (AI) has aided clinicians in the interpretation of electrocardiograms (ECGs) serving as an essential tool to provide rapid triage and care. However, in some cases, AI can misinterpret an ECG and may mislead the interpreting physician. Therefore, we aimed to describe the rate of ECG misinterpretation and its potential clinical impact in patient's management.MethodsWe performed a retrospective descriptive analysis of misinterpreted ECGs and its clinical impact from May 28, 2020 to May 9, 2021. An electrophysiologist screened ECGs with confirmed diagnosis of atrial fibrillation (AF), sinus tachycardia (ST), sinus bradycardia (SB), intraventricular conduction delay (IVCD), and premature atrial contraction (PAC) that were performed in the emergency department. We then classified the misinterpreted ECGs as wrongly diagnosed AF, ST, SB, IVCD, or PAC into the correct diagnosis and reviewed the misinterpreted ECGs and medical records to evaluate inappropriate use of antiarrhythmic drugs (AAD), beta‐blockers (BB), calcium channel blockers (CCB), anticoagulation, or resource utilization of cardiology and/or electrophysiology (EP) consultation.ResultsA total of 4969 ECGs were screened with diagnoses of AF (2282), IVCD (296), PAC (972), SB (895), and ST (638). Among these, 101 ECGs (2.0%) were misinterpreted. Wrongly diagnosed AF (58.4%) was the most common followed by wrongly diagnosed PAC (14.9%), wrongly diagnosed ST (12.9%), wrongly diagnosed IVCD (7.9%), and wrongly diagnosed SB (6.0%). Patients with misinterpreted ECGs were aged 76.6 ± 11.6 years with male (52.5%) predominance and hypertension being the most prevalent (83.2%) comorbid condition. The misinterpretation of ECGs led to the inappropriate use of BB (19.8%), CCB (5.0%), AAD therapy (7.9%), anticoagulation (6.9%) in patients with wrongly diagnosed AF, as well as inappropriate resource utilization including cardiology (41.6%) and EP (8.9%) consultations.ConclusionsMisinterpretation of ECGs may lead to inappropriate medical therapies and increased resource utilization. Therefore, it is essential to encourage physicians to carefully examine AI interpreted ECG's, especially those interpreted as having AF.
Elemi essential oil nanocapsulated drug ameliorates lung cancer via oxidative stress, apoptosis and inflammation pathway
Authors: Kurban Beril , Tuncel Tuğba , Görgülü Şennur , Kar Fatih , Öztürk Alper , Özek Temel 
Published: June 2023

AbstractLung cancer is one of the most common causes of death in the world. Considering the severe side effects, toxicity and high costs of chemotherapeutics used in cancer treatment, there is a need for more economical and natural treatment methods such as essential oils. The purpose of this study is to determine the efficacy of Canarium commune (Elemi) essential oil (EO) and nanoparticles. Elemi EO is analysed by GC‐FID/MS. The antiproliferative effect of Elemi EO and prepared nanoparticles on human lung adenocarcinoma (A549) and their effect on normal fibroblast cells (CCD‐19Lu) were determined by the MTT test. The levels of TAS, TOS, CYCS, CASP3, TNF‐α and IL‐6 parameters of the experimental groups were determined using specific ELISA. BAX and Bcl‐2 genes were studied with qRT‐PCR to investigate the different ways that cancer cells undergo apoptosis. Limonene (53.7%), a‐phellandrene (14.5%) and elemol (10.1%) were the major components of Elemi EO. 24‐Hour IC50 values in the cells were measured for Elemi EO; A549: 1199 μg/mL, CCD‐19Lu: 37.181 μg/mL. TAS and TOS values were found to be higher in cancer cells than in normal cells, and it was found that cancerous cells were dragged into stress and that cancer cells were directed to apoptosis. BAX genes stimulation supported the results. It was determined that Elemi EO and nanoparticles showed anticancer activity without damaging normal cells. Based on these promising results, potential drug candidate Elemi EO loaded nanoparticles may be cell‐specific targeted, oral use possible, new generation nanoparticular drugs.
Financial conflicts of interest between pharmaceutical companies and executive board members of internal medicine subspecialty societies in Japan between 2016 and 2020
Authors: Murayama Anju , Saito Hiroaki , Tanimoto Tetsuya , Ozaki Akihiko 
Published: June 2023

AbstractRationalePharmaceutical companies make payments to physicians such as compensations for lecturing or consulting. Of particular, financial relationships between pharmaceutical companies and leaders of professional medical societies are concern in medical community. However, little was known about them in Japan.Aims and ObjectivesThis study aimed to evaluate the magnitude and prevalence of personal payments to executive board members (EBMs) of 15 medical associations representing different subspecialties within the Japanese Society of Internal Medicine.MethodAll EBMs of 15 medical associations representing internal medicine subspecialties were collected from each association webpage. Payments to the EBMs were extracted from the pharmaceutical companies belonging to the Japan Pharmaceutical Manufacturers Association between 2016 and 2020. We performed descriptive analysis on the payment data.ResultsOf the 353 different EBMs identified, 350 (99.2%) received one or more personal payments from the pharmaceutical companies over the 5 years. 99.2% (350) and 97.2% (343) of all EBMs received personal payments 3 years before and in the year of their board membership. A total of $70,796,014 were made to the EBMs over the 5 years. The median 5‐year combined personal payments per EBM was $150,849 (interquartile range [IQR]: $73,412–$282,456). EBMs who were chairman or vice chairman of executive board received significantly larger median personal payments than those who were not ($225,685 vs. $143,885, p = 0.01 in the U test). Among the 15 societies, there were 12 (80.0%) societies with all (100%) EBMs receiving personal payments from the pharmaceutical companies. Although every society has their own conflicts of interest policy, none publicly discloses the financial relationships between pharmaceutical companies and their EBMs due to their privacy.ConclusionThis study demonstrated that nearly all EBMs of 15 medical associations representing internal medicine subspecialties had substantial financial relationships with the pharmaceutical companies in Japan over the past 5 years.
The E3 ubiquitin ligase SINA1 and the protein kinase BIN2 cooperatively regulate PHR1 in apple anthocyanin biosynthesis
Authors: An Jian‐Ping , Li Hong‐Liang , Liu Zhi‐Ying , Wang Da‐Ru , You Chun‐Xiang , Han Yuepeng 
Published: June 2023

AbstractPHR1 (PHOSPHATE STARVATION RESPONSE1) plays key roles in the inorganic phosphate (Pi) starvation response and in Pi deficiency‐induced anthocyanin biosynthesis in plants. However, the post‐translational regulation of PHR1 is unclear, and the molecular basis of PHR1‐mediated anthocyanin biosynthesis remains elusive. In this study, we determined that MdPHR1 was essential for Pi deficiency‐induced anthocyanin accumulation in apple (Malus × domestica). MdPHR1 interacted with MdWRKY75, a positive regulator of anthocyanin biosynthesis, to enhance the MdWRKY75‐activated transcription of MdMYB1, leading to anthocyanin accumulation. In addition, the E3 ubiquitin ligase SEVEN IN ABSENTIA1 (MdSINA1) negatively regulated MdPHR1‐promoted anthocyanin biosynthesis via the ubiquitination‐mediated degradation of MdPHR1. Moreover, the protein kinase apple BRASSINOSTEROID INSENSITIVE2 (MdBIN2) phosphorylated MdPHR1 and positively regulated MdPHR1‐mediated anthocyanin accumulation by attenuating the MdSINA1‐mediated ubiquitination degradation of MdPHR1. Taken together, these findings not only demonstrate the regulatory role of MdPHR1 in Pi starvation induced anthocyanin accumulation, but also provide an insight into the post‐translational regulation of PHR1.
Informal carer support needs, facilitators and barriers in transitional care for older adults from hospital to home: A scoping review
Authors: Allen Jacqueline , Woolford Marta , Livingston Patricia M. , Lobchuk Michelle , Muldowney Anne , Hutchinson Alison M. 
Published: June 2023

AbstractAimTo synthesise evidence about informal carers' (carers) experience of their support needs, facilitators and barriers regarding transitional care of older adults with multimorbidity.BackgroundCarers provide crucial support for older adults during care transitions. Although health practitioners are well positioned to support carers, system factors including limited healthcare resources can compromise the quality of care transitions.DesignScoping review.MethodsSearches were undertaken of the published literature. Five databases were searched including MEDLINE, CINAHL, EMBASE, PsycINFO and the Cochrane Library. Two reviewers independently screened articles to identify relevant studies. Studies were retrieved from January 2000 to July 2022. Data were extracted and tabulated for study characteristics, support needs, facilitators and barriers. Key themes and patterns were synthesised across the studies.ResultsEighteen studies including N = 3174 participants were retrieved. Most studies (n = 13) employed qualitative designs. Five studies used surveys. Carers reported their need to: be involved in coordinated discharge planning; advocate and be involved in decision‐making; and receive community‐based follow‐up. Carers described facilitators and barriers in four themes: (1) relationships with the older adult and health practitioners, (2) being involved in coordinated discharge planning; (3) communication and information strategies; and (4) community‐based follow‐up. Synthesis of themes across all studies resulted in the identification of five areas of research: carers' health literacy; community‐based care; carers' involvement in transitional care planning; inpatient and community health practitioners' communication skills; and culturally diverse carers' experiences.Conclusion and Relevance to Clinical PracticeThe review highlights the importance of quality communication and relationships between carers, older adults, health practitioners and health organisations. Although information and education are important there is a need for further research to examine systems that support communication between carers, older adults and health practitioners and health literacy for all carers including culturally diverse carers.
Smart Tech is all Around us – Bridging Employee Vulnerability with Organizational ActiveTrust‐Building
Authors: Weibel Antoinette , Schafheitle Simon , van der Werff Lisa 
Published: June 2023

AbstractPublic and academic opinion remains divided regarding the benefits and pitfalls of datafication technology in organizations, particularly regarding their impact on employees. Taking a dual‐process perspective on trust, we propose that datafication technology can create small, erratic surprises in the workplace that highlight employee vulnerability and increase employees’ reliance on the systematic processing of trust. We argue that these surprises precipitate a phase in the employment relationship in which employees more actively weigh trust‐related cues, and the employer should therefore engage in active trust management to protect and strengthen the relationship. Our paper develops a framework of symbolic and substantive strategies to guide organizations’ active trust management efforts to (re‐)create situational normality, root goodwill intentions, and enable a more balanced interdependence between the organization and its employees. We discuss the implications of our paper for reconciling competing narratives about the future of work and for developing an understanding of trust processes.
Learning from failure: The implications of product recalls for firm innovation
Authors: Ni John , Borisov Alexander , Modi Sachin , Huang Xiaowen 
Published: June 2023

AbstractExisting research provides contrasting perspectives on the implications of product recalls for firms. While some studies find that recalls represent failures that can motivate firms to innovate, others suggest that the resource‐intensive nature of recalls may inhibit firms from innovating. This study presents a theoretical framework that reconciles these two perspectives by proposing an inverted U‐shaped relationship between a firm's product recall frequency and innovation output. The paper also evaluates the effect of the firm's growth potential on the recall frequency–innovation relationship. Analysis of data on vehicle recalls and recall‐related patents in the automotive sector from 1980 to 2019 confirms the inverted U‐shaped relationship and shows that the relationship is steepened by the growth potential of the firm. Overall, the study presents a more nuanced understanding of learning from product recalls and bridges the supply chain disruption and innovation literature in the context of product recall.
The author's moral right of withdrawal and its reasonable restriction or contractual waive
Authors: Veiksa Ingrida 
Published: June 2023

AbstractCopyright protects original works of authorship by granting the author economic rights, which give the author an exclusive right of economic exploitation, and moral rights, which protect noneconomic interests of the author. Moral rights are not considered property, but an aspect of the author's personality. The aim of this study is to find a solution how to include one of the author's moral rights—the right of withdrawal—in the national legal acts, so that it meets the interests of both the author himself and the user of the work. The research question is: how much should it be necessary to limit the right of withdrawal so that neither the transferee of the economic rights nor other coauthors of the work suffer from its excessive use? To find an answer to the research question, international and national legal norms of various countries were studied, the materials of international conferences were analyzed, as well as the information available on the Internet about the origin, use, and development of moral rights were taken into account. There is a wide diversity of opinion on the application of right of withdrawal, as well as great differences in the laws of individual countries. Although the laws of Common Law countries include mandatory moral rights (according to the Berne Convention), the right of withdrawal in its classical form is not provided for in any of the analyzed countries. In Civil Law countries are different attitudes to withdrawal rights. Some Civil Law countries have and some have not included these rights in national copyright law. The right of withdrawal can be included in the catalog of moral rights of national copyright laws, but it cannot be an unlimited right. Certain limitations or exceptions must be established for specific types of work or specific situations of use. It should also be possible for the author to contractually transfer or waive certain moral rights in specific situations.
Convergent mechanisms of microglia‐mediated synaptic dysfunction contribute to diverse neuropathological conditions
Authors: Scott‐Hewitt Nicole , Huang Youtong , Stevens Beth 
Published: June 2023

AbstractChanges in synaptic function are an early hallmark of neuropathological conditions that often precede symptom onset, with mounting genetic, transcriptional, and epidemiological evidence implicating microglia in this process. The correlation between infection and neurocognitive sequelae further suggests that environmental exposures modulate neuroimmune interactions and contribute to synaptic alterations. Recent studies investigating functional roles of microglia across broad neuropathological contexts including neurodegeneration, aging, neuropsychiatric and neurodevelopmental disorders, and neurotropic infections reveal convergent mechanisms underlying microglial‐mediated synaptic dysfunction. We propose that early microglial changes, driven by genetic alterations coupled with environmental neuroimmune modulation, may be a common denominator that contributes to early synaptic pathologies. Here we review the evidence and discuss how microglia respond, and contribute, to synaptopathies across diverse neurological conditions, spotlighting their importance as broadly relevant therapeutic targets within neurological diseases.
Discrimination of paediatric acuity test optotypes by 6‐year‐old children
Authors: Hussaindeen Jameel Rizwana , Ramakrishnan Bhavatharini , Ravi Aishwarya , SundarRaj Monisha , Rakshit Archayeeta , Nosofsky Robert M. , Candy T. Rowan 
Published: June 2023

AbstractPurposeTo compare the discrimination performance of 6‐year‐old children for optotypes from six paediatric visual acuity tests and to fit Luce's Biased Choice Model to the data to estimate the relative similarities and bias for each optotype.MethodsFull data sets were collected from 20 typically developing 6‐year‐olds who had passed a vision screening. They were presented with single optotypes labelled 6/12 at a distance of 9 m and were asked to identify the optotype using a matching task containing all optotypes from the relevant test. The data were combined to form a confusion matrix for each test and a biased choice model was fitted to the data.ResultsMedian correct performance varied from 40% to 100% across optotypes, with the HOTV test having the highest values. Estimates of the similarity of each pair of optotypes indicated equal values for all pairs in the Landolt C, HOTV, Lea numbers and Tumbling E tests. The values differed for the picture tests, that is Lea Symbols and Allen figures. The estimates of bias for each individual optotype also indicated different values with the picture tests.ConclusionsPrevious studies of the threshold acuity of young children and adults have indicated differences in acuity estimates across paediatric tests. A recognition acuity task typically requires resolving the difference information between optotypes. The performance of the 6‐year‐olds here reveals variance in similarity and bias values for picture tests, particularly for the Allen figures when compared with the Lea Symbols. Ideally, this analysis should be performed when designing new tests, and these results motivate progression from the use of current picture tests to well calibrated letter or number tests at the earliest possible age.
Long‐term effect of eplerenone treatment in children with chronic allograft nephropathy
Authors: Baskin Esra , Siddiqui Meraj Alam , Gülleroğlu Kaan , Özdemir Binnaz Handan , Yılmaz Aysun Çaltık , Çolak Meriç Yavuz , Akdur Aydıncan , Soy Ebru Ayvazoğlu , Moray Gökhan , Haberal Mehmet 
Published: June 2023

AbstractBackgroundLiterature supports the protective role of mineralocorticoid antagonist (MRA) against the renal injury induced by aldosterone in kidney transplant recipients. However, there is limited data available regarding the safety and efficacy of MRAs in pediatric renal transplant patients. Therefore, we aimed to investigate the effect of long‐term eplerenone administration in children with chronic allograft nephropathy (CAN).MethodsTwenty‐six renal transplant children with biopsy‐proven CAN, an estimated glomerular filtration rate (eGFR ) > 40 mL/min per 1.73 m2 and with a significant proteinuria were included. Selected patients were randomly divided into two groups as follows; Group 1 (n = 10) patients received 25 mg/day eplerenone and Group 2 (n = 16) patients did not receive eplerenone for 36 months. Patients were examined in the renal transplant outpatient clinic biweekly for the first month and once a month thereafter. The primary outcome of the patients was compared.ResultsMean eGFR stayed stable in group 1 patients, but significantly decreased in group 2 at 36 months (57.53 ± 7.53 vs. 44.94 ± 8.04 mL/min per 1.73 m2, p = .001). Similarly, spot protein–creatinine ratio was significantly lower in group 1 compared to group 2 patients at 36 months (1.02 ± 7.53 vs. 3.61 ± 0.53, p < .001). Eplerenone associated hyperkalemia was not observed in group 1 patients (4.6 ± 0.2 vs. 4.56 ± 0.3, p = .713).ConclusionThe long‐term eplerenone administration blunted the chronic allograft nephropathy by maintaining a stable eGFR levels and decreasing urine protein–creatinine ratio. Eplerenone associated hyperkalemia was not observed in our study.