bluuebunny/crossref_metadata_2025_split huggingface dataset:
Szacowanie wartości współczynnika przewodności cieplnej skał dolomitu głównego na podstawie składu mineralnego i porowatości
Authors:   Instytut Nafty i Gazu – Państwowy Instytut Badawczy, Przelaskowska Anna , Kubik Benedykt ,   Instytut Nafty i Gazu – Państwowy Instytut Badawczy
Published: February 2023

Jednym z niezbędnych parametrów do określenia warunków termicznych zbiornika geotermalnego jest współczynnik przewodności cieplnej skał. Przewodność cieplna zależy od innych własności skał, takich jak skład mineralny i porowatość. Do obliczenia wartości tego parametru można więc stosować modele matematyczne uwzględniające zarówno zawartość objętościową i przewodność cieplną poszczególnych minerałów i roztworów porowych, jak i strukturę skały. W pracy wykorzystano różnego rodzaju modele, od najprostszych, warstwowych, po bardziej skomplikowane modele inkluzji niesferycznych. Obliczone wartości zweryfikowano na podstawie pomiarów laboratoryjnych przewodności cieplnej. Badania wykonano na próbkach dolomitu charakteryzujących się mało zróżnicowanym składem mineralnym, a jednocześnie dużą zmiennością porowatości (od 3% do 27%). Parametr porowatości ma widoczny wpływ na dopasowanie poszczególnych modeli matematycznych. Najlepszą zbieżność wartości pomierzonych i wyliczonych uzyskano w przypadku próbek o wysokiej porowatości (powyżej 25%) za pomocą modelu średniej arytmetycznej. W przypadku próbek o niższej porowatości najlepsze dopasowanie otrzymano przy wykorzystaniu modelu średniej harmonicznej, modelu inkluzji sferycznych (przypadek skały składającej się ze sferycznych ziaren rozproszonych w roztworze porowym) oraz modeli inkluzji niesferycznych (przypadek porów w formie szczelin o kształcie dysków). Wszystkie modele dobrze odzwierciedlają trendy zmienności otrzymane dla wartości pomierzonych. Uzyskane korelacje charakteryzują się wysokimi współczynnikami determinacji R2, przekraczającymi 0,86. Wysoka jakość korelacji pozwoliła na wprowadzenie poprawki umożliwiającej przybliżenie wartości wymodelowanych do rzeczywistych. Otrzymane wyniki pozwoliły na dobór optymalnych modeli umożliwiających ocenę wartości przewodności cieplnej dolomitów na podstawie składu mineralnego. W przypadku skał o bardzo wysokiej, przekraczającej 25%, porowatości najlepiej dopasowuje się model średniej arytmetycznej. W przypadku pozostałych próbek najlepszą zgodność wartości wyliczonych i pomierzonych uzyskano po zastosowaniu poprawki; wyniki są bardzo zbliżone dla wszystkich zastosowanych modeli.
Kompatybilność rop badana z zastosowaniem mikroskopu wysokociśnieniowego w warunkach dynamicznych
Authors:   Instytut Nafty i Gazu – Państwowy Instytut Badawczy, Szuflita Sławomir , Krasodomski Wojciech ,   Instytut Nafty i Gazu – Państwowy Instytut Badawczy, Kuśnierczyk Jerzy ,   Instytut Nafty i Gazu - Państwowy Instytut Badawczy, Wojnicki Mirosław ,   Instytut Nafty i Gazu - Państwowy Instytut Badawczy, Warnecki Marcin 
Published: February 2023

Ze względu na wysoką cenę lekkich rop większość rafinerii skłania się do zakupu większych ilości tańszych rop „okazyjnych”, które są cięższe i zawierają wyższe stężenia siarki i kwasów naftenowych. Takie podejście doprowadza do większej częstotliwości prac serwisowych związanych z oczyszczaniem instalacji procesowej w rafinerii. Na szczęście zrozumienie przyczyn i metod łagodzenia wytrącania się zanieczyszczeń ropopochodnych uległo ostatnio znacznej poprawie dzięki opracowaniu narzędzi do przewidywania i identyfikacji. Co zaskakujące, 90% zanieczyszczeń ropopochodnych w rafinacji ma tylko kilka wspólnych przyczyn. Analiza osadu zwykle pozwala na zidentyfikowanie pierwotnej przyczyny, którą potwierdza odnalezienie prekursora tego niekorzystnego zjawiska w ropie naftowej przepływającej przez zanieczyszczoną jednostkę instalacji. Odpowiednie rozpoznanie zagadnienia może wprowadzić szereg potencjalnych metod łagodzących, z których dana rafineria może wybrać najlepszą do wdrożenia. Każdy kraj na świecie dąży do osiągnięcia jak największego bezpieczeństwa energetycznego, a tym samym do dywersyfikacji dostaw ropy i innych surowców. W przypadku ropy, gdy pozyskiwana jest ona z różnych źródeł, generuje się dodatkowy problem, a mianowicie kompatybilność. Okazuje się, że po zmieszaniu niektóre ropy wykazują tendencje do wytrącania osadów w zbiornikach magazynowych, a następnie w ciągu logistycznym. W jednej z poprzednich prac opracowano skuteczną metodę filtrowania pozwalającą na określenie kompatybilności rop i ich mieszanin. W obecnej pracy skoncentrowano się na tym, aby nowa metoda pozwoliła na szybszą możliwość wykonania pomiaru kompatybilności przy jednoczesnej możliwości ponownego wykorzystania tej samej próbki. Opracowany nowy sposób badań kompatybilności z wykorzystaniem mikroskopu (ang. high-pressure microscope, HPM) zastosowano do dwóch rop pochodzących z różnych kierunków dostaw. Pomiary wykonano dla rop i ich mieszanin w temperaturze 120°C i pod ciśnieniem 25 bar. Pomiar kompatybilności rop metodą filtrowania wykorzystano do celów porównawczych, gdzie masa odseparowanego osadu na specjalistycznych filtrach stanowiła wyznacznik kompatybilności badanych rop.
Quadriceps Strain and TKA: Contribution of the Tourniquet and Intramedullary Rod to Postoperative Thigh Pain
Authors: Stocks Gregory W. , Odoemene Melissa , Gex Julia , Vidal Emily A. , Sawyer Kathryn , Jones Stephen L. , Thompson Brandon , Laughlin Mitzi S. 
Published: February 2023

Background:
Thigh pain is relatively common after total knee arthroplasty (TKA) and has been attributed to compression of the thigh muscles by the tourniquet used during surgery. Thigh pain that occurs after a TKA that was performed without a tourniquet may be due to a strain of the quadriceps muscle or insertion of the intramedullary (IM) rod. The purpose of the present study was to determine the cause of thigh pain after TKA in a randomized controlled trial evaluating tourniquet use, IM rod use, and quadriceps strain.

Methods:
This prospective randomized controlled trial enrolled 97 subjects undergoing primary knee arthroplasty into 4 groups according to tourniquet use (yes or no) and IM rod use (yes or no). Quadriceps strain was evaluated with magnetic resonance imaging (MRI) on postoperative day 1 (POD 1). Data collected preoperatively, intraoperatively, and postoperatively until the 6-week clinical visit included pain levels for the knee and thigh (recorded separately) and knee range of motion.

Results:
Regardless of tourniquet or IM rod use, 73 (75%) of the 97 patients reported thigh pain on POD 1. Thigh pain at 2 weeks postoperatively was indicative of a quadriceps strain. Use of a tourniquet and patient-reported thigh pain at 2 weeks increased the odds of a quadriceps strain, whereas IM rod use did not significantly contribute to thigh pain.

Conclusions:
The etiology of thigh pain after TKA may be multifactorial; however, an iatrogenic quadriceps strain is one source of thigh pain after TKA, especially if the pain persists 2 weeks after surgery.

Level of Evidence:
Prognostic Level I. See Instructions for Authors for a complete description of levels of evidence.
Derivation of axioloids, an in vitro model of somitogenesis and axial development from human pluripotent stem cells
Authors: Yamanaka Yoshihiro , Hamidi Sofiane , Ericsson Rolf , Munira Sirajam , Alev Cantas 
Published: February 2023

Abstract
Here we describe a step-by-step protocol for the derivation of axioloids, a pluripotent stem cell (PSC)-based 3D in vitro model of human segmentation and somitogenesis. Mesoderm-based axioloids capture reproducibly core features of the segmentation process in vitro including axial elongation, sequential formation of properly patterned epithelial somites and coordinated oscillatory activity of the segmentation clock. Axioloids recapitulate furthermore key morphogenetic and molecular features of post-gastrulation human embryos, including temporally coordinated emergence and spatial organization of somitogenesis-associated mesodermal cell populations, presence of opposing FGF/WNT and RA signaling gradients and spatiotemporally controlled expression of HOX genes. In addition to increasing our still limited understanding of human axial development, axioloids can be used to model and study congenital diseases of the human spine, when utilizing patient-like iPSCs with defined pathogenic mutations in genes such as HES7 or MESP2.
Detection and Prevention of Black Hole Attack in MANET using Node Credibility and Andrews Plot
Authors: Kumari Ankita , Dutta Sandip , Chakraborty Soubhik 
Published: February 2023

Abstract
MANET, a wireless, infrastructure-less, ad-hoc network, uses a dynamic topology rendering for the establishment of connections much easier in any given conditions. The black hole attack is a malicious activity that is performed in MANET which causes depletion of the network. It poses a threat to MANET by incorporating malicious nodes into the network which gives fake routing information to the source node. As the black hole attack acquires the data from the source node, it drops the data packet from the network resulting in the depletion of the network. In this paper, to tackle the black hole attack, we have proposed a node credibility-based approach focusing on Andrews plot to project the node credibility after a few transactions which infer that a high node with high node credibility is the more trusted node in the network. We have used Network Simulator software for the creation of MANET scenarios.
An integrated, non-destructive method for evaluating core quality from R/V Legend’s giant piston coring system
Authors: Yu Pai-Sen , Chen Ting-Ting 
Published: February 2023

Abstract
The quality of marine sediment cores is significant for investigations on marine geohazards, paleoceanography, paleoclimatology, and marine environmental changes. The identification of genuine or artificial sedimentary structures is essential to the development of long piston coring procedures. In this study, we highlight an overlooked primary process of a standard procedure and its effect on the deformation of a sedimentary sequence. The LGD-T32/LGD-T43 cruises of the R/V Legend were designed to test the capability of 8-m-long piston coring offshore southwestern Taiwan. To examine how giant piston coring procedures have shaped the retrieval of sedimentary sequences and affected core quality, we apply well-developed, non-destructive analyses, including physical property measurements, visible color reflectance and the curvature index, to recovered sediments. The continuous sequences of four giant sediment cores at the revisited site are therefore used to provide the basis for comparison with non-destructive results. Rather than dewatering or lithifying the units themselves, we suggest that during the coring procedure, an abnormal pulling force could destroy the balance among the sediments and thus cause the observed deformations of sedimentary features with different magnitudes. We demonstrate that an integration of the curvature index and color reflectance is a better way to evaluate the transformation and distorted sedimentary sequences. Furthermore, using a Taiwan Ocean Research Institute (TORI)-revised piston could potentially produce an abnormal pulling force inside a tube and causing oversampling and distorted sedimentary features, as evidenced by integrated results.
Thermal vibration analysis of scramjet engine structure based on the coupling combustion-thermal-structure approach
Authors: niu yaobin , wang zhongwei 
Published: February 2023

Abstract
A combustion-thermal-structure coupling approach for thermal vibration analysis of scramjet structure is proposed, and it can consider the influences of flight trajectory such as flight altitude, flight Mach number and combustion equivalence ratio on engine vibration characteristics. In this approach, the internal flow field parameters such as pressure and temperature of scramjet engine are determined by means of the quasi one-dimensional model, the combustion heat flow parameters of engine wall are determined by the reference enthalpy method, and the transient structure heat transfer and thermal structure analysis are determined by the finite element method. Based on this approach, the thermal vibration frequency of the scramjet engine and its variation with time are studied. Under the condition of the hypersonic flight, the structural frequency of the scramjet engine decreases gradually with time, and there are great differences in the reduction amplitude at each frequency due to the uneven distribution of structural temperature. In the inlet section with relatively lower temperature, the declining amplitude ratio of inlet breathing and bending modes is the smallest, and the declining in the first 200s is 11.28% and 14.16% respectively. The structure temperature of combustion chamber and nozzle is relatively high, and the corresponding third-order, fourth-order and fifth-order frequencies decrease more, which are 35.81%, 34.32% and 32.36% respectively. The variation of the free vibration frequency of the scramjet engine with flight trajectory such as flight Mach number and flight altitude is studied. With the increase of Mach number, the engine structure temperature increases faster, and each order frequency decreases faster. With the decrease of flight altitude, the heat flux on the inner wall of the scramjet engine increases, the structural temperature rises faster, and the frequency decreases more at the same time. In addition, because the total temperature in the scramjet thermal environment changes little, the transient temperature of the engine structure at different heights finally tends to the same value, and the structural modal frequency finally tends to the same. The combustion equivalence ratio of the scramjet engine owns a great influence on the temperature of combustion chamber and nozzle. With the increase of the engine combustion equivalence ratio, the temperature of engine combustion chamber and nozzle increases, and its first-order, third-order, fourth-order and fifth-order frequencies decrease faster, while the inlet is not affected by the equivalence ratio, thus the second-order and sixth-order frequencies change little. This study can provide a strategy for predicting the full flight trajectory vibration characteristics of the scramjet engine, and provide support for the structural optimization design and vibration response reduction of the scramjet engine.
Electrospherization of genistein@DNA core-shell nanospheres as a drug delivery system and theoretical study of the release mechanism
Authors: Elsherbeny Aya A. , Motawea Amira , Tawfik Ashraf M. , Gabr Mohamed M. , Elmezayyen Ayman S. 
Published: February 2023

Abstract
The practical application of genistein (GEN) as a drug system is hindered by its low aqueous solubility and poor oral bioavailability. Encapsulation of poor water-soluble drug was considered as one of the widely used approaches to overcome such of these obstacles. The primary goal of this research was to in situ encapsulate the hydrophobic GEN during the electrosynthesis of DNA nanospheres as a delivery system (Es GEN@DNA) with appropriate drug release properties. The prepared Es GEN@DNA nanospheres were characterized using UV-visible spectroscopy, X-ray diffraction analysis (XRD), transmission electron microscope (TEM), zeta potential and stability test. The results revealed that GEN was successfully encapsulate in situ during the DNA electrospherization (Es GEN@DNA) as core shell like structure (Core: GEN and Shell: DNA) with a wonderful stability against time. Furthermore, the drug encapsulation % was studied. In addition, the drug release efficiency of Es GEN@DNA was recorded and theoretically visualized to understand the mechanism and kinetics of GEN drug release. %Encapsulation of GEN within DNA nanospheres was found to be 89.62%. Es GEN@DNA release profile explored that the well entrapped GEN within the DNA nanospheres could be a promising for sustained drug release. Besides, we overcome the dilemma of using a fractal or fractional kinetics model by introducing a general fractional kinetic equation that involves a time-dependent rate coefficient, which introduced that the solution of the fractional kinetic model is capable of fitting the release data profiles of free GEN and Es GEN@DNA.
Efficacy and safety of artificial liver support system treatment for immune checkpoint inhibitors related liver failure in patients with hepatocellular carcinoma: a randomized controlled clinical trial
Authors: Luo Qiumin , Zhang Yeqiong , Li Yangmei , Li Zhipeng , Chen Jia , Deng Zhexuan , Lai Jiadi , Peng Liang , Mei Yongyu , Xu Wenxiong 
Published: February 2023

Abstract
Background: It is well-established that immune checkpoint inhibitors-induced immune-mediated hepatitis (ICIs-IMH) in patients with hepatocellular carcinoma (HCC) increases susceptibility to liver failure (LF). Given mounting evidence that artificial liver support system (ALSS) treatment can effectively relieve both IMH and LF, a single-center, non-blinded, randomized controlled clinical trial will be conducted to investigate the efficacy and safety of ALSS for HCC patients with ICIs-LF.
Methods and analysis:Sixty participants who meet the eligibility criteria will be enrolled in this trial and randomized to one of two arms at a 1:1 ratio. In addition to comprehensive pharmacological treatment, patients in the trial group will receive treatment with double plasma molecular adsorption system (DPMAS) and low volume plasma exchange (LPE) three times, while patients in the control group will undergo PE three times. Patient evaluations, including symptoms and laboratory tests, will be performed at baseline, before and after the three times of ALSS treatment, and 2, 4, 8, and 12 weeks after enrollment. The primary outcome is the mortality rate at 12-week follow-up. The secondary outcomes include the change in the Model for end-stage liver disease (MELD) score after ALSS treatment and the incidence of adverse events (AEs).
Discussion: ICIs-LF in patients with HCC have a high mortality rate and lacks effective treatment. Our study can evaluate the efficacy and safety of ALSS for this patient population, and compare the two modes of ALSS (DPMAS+LPE vs. DPMAS).
Trial registration: ClinicalTrials.gov ID: NCT05484908 (Release Date: July 30, 2022).
Comparison of effects and brain imaging mechanisms of acupuncture and paroxetine for depressive patients with suicidal ideation: study protocol of a 20-week clinical trial
Authors: Li Qifu , Lu Yi , Sun Jinbo , Huang Gaoyangzi , Gong Yi , Zhang Bingkui , Chen Ziwen , Zhang Xinghe , Huang Ya , Zeng Xuanxiang , Zhao Siwen , Tang Xin , Pei Xianmei , Zhang Renrui , Guo Taipin , Liang Fanrong 
Published: February 2023

Abstract
Background Suicide is a devastating and major medical and social problem, and effective management of depression with suicidal ideation (DWSI) is of significant importance in reducing suicide rates. Acupuncture has been less studied in DWSI, and its central mechanisms have not been elucidated. This study aims to carry out a clinical trial using multimodal brain imaging techniques to investigate the mechanism of brain network regulation of DWSI by acupuncture.
Method A total of 70 patients with DWSI and 30 healthy subjects will be recruited for this study. This trial will include a 1-week baseline phase, a 12-week treatment phase, and a 8-week follow-up phase. Patients in the acupuncture group will receive 36 sessions of acupuncture, 3 times a week for 12 weeks. Patientsin the paroxetine control group will receive paroxetine 10 mg per day (week 1), 20 mg per day (weeks 2); and 30 mg per day (weeks 3-12). The primary outcomes are the mean change in the Hamilton Depression Rating Scale-24 scores and the Beck scale for suicide ideation. The secondary outcomes include the Depression Self-Rating Scale, Clinical Global ImpressionsScale, Asberg Antidepressant side effect scale and World Health Organization Quality of Life Questionaire abbreviated version. Magnetic resonance imaging data will be collected from each participant at baseline and each patient at the end of treatment.
Conclusions This study hypothesised that acupuncture therapy could treat DWSI by restoring the pathological center of suicidal ideation in brain. This study will clarify the mechanism of brain network regulation of DWSI by acupuncture.
Trial registration number ChiCTR2200059267, registered on April 7, 2022.
DMT-(S)-Pro-OSu derivatization UPLC/ESI-MS/MS is a powerful method for the comprehensive analysis of dipeptides
Authors: Ito Keisuke , Terada Yuko , Nakayama Ryoka , Shigeta Takashi , Hisada Takumi , Fujitani Masaya , Kanie Kei , Kato Ryuji , Fukui Serina , Sugiyama Eiji , Mizuno Hajime , Todoroki Kenichiro 
Published: February 2023

Abstract
Dipeptides are important components that contribute to the characteristics of various foods; however, the dipeptide composition of foods is poorly understood. In the present study, a new, comprehensive analysis method for dipeptides, i.e., (S)-2,5-dioxopyrrolidin-1-yl-1-(4,6-dimethoxy-1,3,5-triazin-2-yl)pyrrolidine-2-carboxylate (DMT-(S)-Pro-OSu) derivatization ultra-performance liquid chromatography–electrospray ionization tandem mass spectrometry (UPLC/ESI-MS/MS), was developed. Using the method, the analytical behavior of 313 dipeptides in the UPLC/ESI-MS/MS was collected. The obtained comprehensive dataset elucidated the dipeptide profiles in fermented cocoa beans. Furthermore, the machine learning on the dataset provided the quantitative understanding of physicochemical molecular descriptors that affect the elution time of dipeptides on the reversed-phase LC analysis, namely, an in silico elution time prediction model was successfully constructed. The DMT-(S)-Pro-OSu derivatization UPLC/ESI-MS/MS method is a powerful tool for the comprehensive analysis of dipeptides.
Parameter Estimation of a Valve-Controlled Cylinder System Model Based on Bench Test and Operating Data Fusion
Authors: Su De-Ying , Wang Shao-Jie , Lin Hao-Jing , Xia Xiao-Song , Xu Yu-Bing , Hou Liang 
Published: February 2023

Abstract

The accurate estimation of parameters is the premise for establishing a high-fidelity simulation model of a valve-controlled cylinder system. Although bench test data are convenient to obtain in model parameter estimation, there is a need for the load data to conform to the actual working conditions. Although the operating data include the actual load information, it is not easy to collect the control valve operating data. This paper proposes a model parameter estimation method based on bench test and operating data fusion to solve the above problems. The proposed method is based on Bayesian theory, and its core is a pool fusion of prior information from bench test and operating data. First, a system model is established, and the parameters in the model are analysed. Then, the bench test and operating data of the system are collected, and the model parameters and weight coefficients are estimated using the data fusion method. Finally, the estimated effects of the data fusion method, Bayesian method, and PSO algorithm on system model parameters are compared. The research shows that the parameter estimation result based on the data fusion method is accurate. The weight coefficient represents the contribution of different prior information to the parameter estimation result. The effect of parameter estimation based on the data fusion method is better than that of the Bayesian method and the PSO algorithm. The more complex the load is, the worse the model's accuracy, which verifies the influence of the load on the valve-controlled cylinder system model and proves that the data fusion method plays an essential role in parameter estimation studies.