bluuebunny/crossref_metadata_2025_split huggingface dataset:
What is the current state of precision rehabilitation? Protocol for a scoping study with a consultation phase
Authors: Pouliot-Laforte Annie , Dubé Evemie , Kairy Dahlia , Levac Danielle E 
Published: January 2025

IntroductionPrecision health can be described as the right intervention, at the right time, for the right person, with a focus on monitoring and maintaining health in a longitudinal approach. Despite an increasing focus on precision approaches in medicine, their application in a rehabilitation context remains unexplored. As such, a greater understanding of the current state of the literature is required, in combination with clinician, researcher and healthcare manager perspectives regarding barriers and facilitators to the practical implementation of precision rehabilitation in clinical practice.ObjectiveDescribe and map the current state of knowledge regarding precision rehabilitation to identify gaps in knowledge and inform future research directions and clinical implementation strategies.Methods and analysisA scoping study will be conducted following current methodological recommendations (Peterset al, 2021) and reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses—Scoping Review Extension guidelines. A convergent mixed-methods design will combine quantitative and qualitative findings. A search in Medline, CINAHL, Embase, Scopus, Web of Science and PsycINFO databases will be conducted for articles published between 2010 and 2023 referring to the concept of precision rehabilitation. Two reviewers will complete an abstract and full-text review based on eligibility criteria; data will be extracted from accepted papers using a data extraction framework. Results will be aggregated and synthesised using descriptive and thematic analyses. The consultation phase will involve a purposeful sampling of key stakeholders (clinicians, researchers and managers) in large North American rehabilitation centres. Semi-structured individual interviews will be conducted and analysed using deductive thematic analysis. Convergent mixed-methods data analyses will combine quantitative and qualitative datasets to highlight similarities and differences between the current literature on the subject and the understanding of stakeholders.Ethics and disseminationEthical approval has been obtained from the Research Ethics Board of the Sainte-Justine University Health Centre (no. 2024–6324). Results will be disseminated through professional networks, conference presentations and publications in scientific journals.
Stress dynamics between clinical supervisors and allied health students: a scoping review protocol
Authors: Wang Piao , Peebles Laurie , O'Connor Aine , Li Xinrong , Wang Yongsheng 
Published: January 2025

IntroductionThe aim of this scoping review is to connect theoretical research related to stress with practical applications to supervision experiences within allied health professions. Understanding the implications of stress between clinical supervisors and allied health students will allow for better insights to improve supervisory methods within clinical training, stronger mentorship and lead to better quality patient care.Methods and analysisThis review is conducted according to Joanna Briggs Institute (JBI) methodology for scoping reviews, which includes defining the research question, developing inclusion criteria and searching for, selecting, extracting and analysing the evidence. A literature search will be conducted in MEDLINE (PubMed), CINAHL (EBSCO), ERIC (EBSCO), PsycINFO (EBSCO) and Embase (Elsevier), as well as various grey literature resources. Studies will be included if they focus on undergraduate or graduate allied health students in a clinical setting and allied health clinical educators, and report on outcomes related to stress dynamics between these two populations. Results will pass through title/abstract and full-text screening before data are extracted using a tool developed by the reviewers. Data will be analysed and summarised descriptively and presented in both tabular and narrative formats.Ethics and disseminationEthical approval is not required for this scoping review. Results will be disseminated in peer-reviewed publications and professional conferences.Trial registration numberThe protocol was registered with Open Science Framework on 2 October 2024 (https://doi.org/10.17605/OSF.IO/REK7Z).
Disappearance of spinal catheter tip due to catheter stretching: a case report
Authors: McGrath Jack , Hussein Kareem 
Published: January 2025

BackgroundContinuous spinal anesthesia (CSA) offers precise, prolonged neuraxial anesthesia suitable for high-risk patients. This technique minimizes hemodynamic instability but comes with notable challenges. Vigilant catheter management is crucial to avoid complications, including the risk of catheter retention. We report a case where the mechanical properties of a spinal catheter led to diagnostic uncertainty.CaseAn ASA4 patient underwent a revision of total knee replacement surgery under CSA using a Pajunk IntraLong catheter set. Following successful insertion, the surgery proceeded uneventfully. During catheter removal, the expected tip markings were absent, raising concern for a retained fragment. Imaging confirmed no retained foreign body. To investigate further, stretching of a new catheter replicated the disappearance of tip markings. This finding suggested that the catheter’s material had the potential to stretch under tension, leading to fading of the markings and mimicking a retained fragment.ConclusionsThis case underscores the need for awareness of the mechanical properties of spinal catheters, especially their potential for stretching and loss of tip markings. Understanding these characteristics can prevent unnecessary imaging and reduce patient and clinician anxiety.
A reconfigurable entanglement distribution network suitable for connecting multiple ground nodes with a satellite
Authors: Vinet Stéphane , Tannous Ramy , Jennewein Thomas 
Published: January 2025

Abstract
Satellite-based quantum communication channels are important for ultra-long distances. Given the short duration of a satellite pass, it can be challenging to efficiently connect multiple users of a city-wide network while the satellite is passing over that area. We propose a network with dual-functionality: during a brief satellite pass, the ground network is configured as a multipoint-to-point topology where all ground nodes establish entanglement with a satellite receiver. During times when this satellite is not available, the satellite up-link is rerouted via a single optical switch to the ground nodes, and the network is configured as a pair-wise ground network. We numerically simulate a pulsed hyper-entangled photon source and study the performance of the proposed network configurations for quantum key distribution. We find favourable scaling in the case that the satellite receiver exploits time-multiplexing whereas the ground nodes utilize frequency-multiplexing. The scalability, simple reconfigurability, and easy integration with fibre networks make this architecture a promising candidate for quantum communication of many ground nodes and a satellite, an important step towards interconnection of ground nodes at a global scale.
Sphingosine-1-Phosphate, a Marker of Endothelial Injury and Disease Severity in Preeclampsia
Authors: Edvinsson Camilla , Piani Federica , Matthes Frank , Vanherle Lotte , Erlandsson Lena , Meissner Anja , Hansson Stefan Rocco 
Published: January 2025

BACKGROUND:
Preeclampsia is a hypertensive pregnancy disorder marked by endothelial damage. Healthy endothelium is covered by a protective glycocalyx layer, which, when degraded, releases detectable products into the blood. Sphingosine-1-phosphate (S1P) is a cardiovascular biomarker involved in glycocalyx preservation, linked to placentation and preeclampsia development. The study aimed to test the hypothesis that plasma S1P is altered alongside glycocalyx degradation products in severe preeclampsia compared with controls.

METHODS:
We included 121 females: 41 with severe preeclampsia requiring treatment in the intensive care unit, 40 with preeclampsia but no need of intensive care unit treatment, and 40 with normotensive pregnancies. Plasma levels of S1P and glycocalyx degradation products—hyaluronic acid, SDC-1 (syndecan-1), and HSPG2 (heparan sulfate proteoglycan-2)—were analyzed from blood samples taken within 27 hours postpartum.

RESULTS:

Postpartum plasma S1P was significantly lower in the intensive care unit cohort compared with both preeclampsia controls and normotensive controls (
P
<0.001). Hyaluronic acid and SDC-1 levels were elevated in the intensive care unit group versus normotensive controls (
P
=0.009 and
P
=0.023), while HSPG2 was lower (
P
<0.001). Plasma S1P correlated with hyaluronic acid and blood pressure.

CONCLUSION:
Intensive care patients with severe preeclampsia have lower plasma S1P levels and higher concentrations of glycocalyx degradation products, indicating more pronounced endothelial damage. These findings suggest that S1P is associated with preeclampsia severity and may serve as a biomarker to assess vascular damage in this patient population. Further studies are needed to explore the potential role of S1P in long-term cardiovascular risk assessment for patients with preeclampsia.
Pandemic-Era School Staff Shortages: Evidence from Unfilled Position Data in Illinois
Authors: Bruno Paul 
Published: January 2025

Abstract
Concerns about school staff shortages are longstanding. However, data on shortages are limited, dated, and rare for non-teaching staff. I use administrative data on unfilled certificated positions in Illinois public schools from the fall of 2022 to paint a detailed picture of shortages across teaching, administrative, and other roles, between districts, and between schools. Teacher and administrator shortage rates are low on average, but shortages of other staff - mostly paraprofessionals - are more severe. However, staff-to-student ratios have increased recently for all staff types. Shortages vary substantially between schools within districts and across urbanicity, grade level, and student characteristics, often in ways that likely exacerbate inequities.
Investigating causal associations between pork intake and multiple sclerosis using Mendelian randomization: Insights from large-scale GWAS data in European populations
Authors: Ye Zhinan , Liu Hongwei , Shi Luya , Ke Xiaoyong 
Published: January 2025

Background Observational studies propose associations between dietary factors and multiple sclerosis (MS). However, the causal nature of these relationships remains unclear. This study aims to determine whether nutritional factors causally influence MS risk through Mendelian randomization (MR) analysis. Methods Summary statistics for 15 common dietary factors were derived from the Genome-Wide Association Study (GWAS) conducted by the Medical Research Council Integrated Epidemiology Unit (MRC-IEU). The GWAS data of MS were sourced from the International Multiple Sclerosis Genetics Consortium (IMSGC), including 14,498 cases and 24,091 controls. The inverse-variance weighted (IVW) method was utilized as the primary analytical approach to estimate causality, while Cochran's Q test assessed heterogeneity. MR-Egger (MRE) and MR-Pleiotropy RESidual Sum and Outlier (MR-PRESSO) were employed to detect pleiotropy and conduct sensitivity analyses. Results We executed univariable- and multivariable-adjusted MR analyses, incorporating adjustments for past tobacco smoking, particulate matter air pollution (PM2.5) and moderate to vigorous physical activity. The univariable Mendelian randomization (UVMR) analysis elucidated potential causal relationships concerning the risk of MS for only two dietary factors: pork intake (odds ratio [OR] = 6.764, 95% confidence interval [CI]: 1.772–25.814, p = 0.005 by IVW) and fish/liver oil dietary supplements (OR = 0.119, 95%CI: 0.032–0.444, p = 0.002 by IVW). In the multivariate Mendelian randomization (MVMR) analysis, the significant causal relationship between pork intake and MS remained robust even after adjusting for potential confounders. Conversely, after adjusting for these confounders, the initially observed causal associations between fish/liver oil dietary supplements and MS ceased to be statistically significant. Conclusions Our findings suggest that pork intake could increase the risk of MS. Other nutritional factors analyzed in this study did not exhibit significant correlations with MS.
Utilizing deep learning for automatic segmentation of the cochleae in temporal bone computed tomography
Authors: Li Zhenhua , Zhou Langtao , Tan Songhua , Liu Bin , Xiao Yu , Tang Anzhou 
Published: January 2025

Background Segmentation of the cochlea in temporal bone computed tomography (CT) is the basis for image-guided otologic surgery. Manual segmentation is time-consuming and laborious. Purpose To assess the utility of deep learning analysis in automatic segmentation of the cochleae in temporal bone CT to differentiate abnormal images from normal images. Material and Methods Three models (3D U-Net, UNETR, and SegResNet) were trained to segment the cochlea on two CT datasets (two CT types: GE 64 and GE 256). One dataset included 77 normal samples, and the other included 154 samples (77 normal and 77 abnormal). A total of 20 samples that contained normal and abnormal cochleae in three CT types (GE 64, GE 256, and SE-DS) were tested on the three models. The Dice similarity coefficient (DSC) and Hausdorff distance (HD) were used to assess the models. Results The segmentation performances of the three models improved after adding abnormal cochlear images for training. SegResNet achieved the best performance. The average DSC on the test set was 0.94, and the HD was 0.16 mm; the performance was higher than those obtained by the 3D U-Net and UNETR models. The DSCs obtained using the GE 256 CT, SE-DS CT, and GE 64 CT models were 0.95, 0.94, and 0.93, respectively, and the HDs were 0.15, 0.18, and 0.12 mm, respectively. Conclusion The SegResNet model is feasible and accurate for automated cochlear segmentation of temporal bone CT images.
Glut-1 exerts anti-tumor activity in glioma by regulating AKT / mTOR signaling pathway
Authors: Li Zhimei , Zhang Guofeng 
Published: January 2025

Objective Glioma is a common tumor in neurosurgery. Glut-1 is the main carrier of glucose uptake by cells and can provide energy through the glycolytic pathway. However, the role and related mechanisms of Glut-1 in glioma have not yet been elucidated. Methods Real time PCR and Western blot were done to assess Glut-1 level in glioma tumor tissues and adjacent tissues. Glioma U87 cells were separated into control group; Glut-1 negative control (NC group); and Glut-1 siRNA group followed by analysis of Glut-1 expression, cell proliferation by MTT assay, cell invasion, cell apoptosis and cycle by flow cytometry and AKT / mTOR signaling proteins level by Western blot. Results Glut-1 expression was significantly increased in the tissues of glioma patients (P < 0.05) compared to adjacent tissues and its level was related to tumor size, pathological grade and survival. Down-regulating the expression of Glut-1 can significantly inhibit tumor cell proliferation and invasion, increase apoptosis and induce G0 phase of cell cycle arrest, and inhibit the expression of AKT / mTOR signaling proteins phosphorylation (P < 0.05). Conclusions Glut-1 level in glioma tissues is significantly increased, which is related to the pathological features. Down-regulating Glut-1 can inhibit glioma by regulating the AKT / mTOR signaling pathway.
EXPRESS: The Predictor Role of Perceived Consumer Effectiveness and Environmental Concern in Consumer Green Behavior: A Meta-analysis with Cultural-level Moderators
Authors: Vieira Valter Afonso , Araújo Clécio Falcão , Groening Christopher 
Published: January 2025

Consumers do not always act in accordance with their environmental concerns and intentions. Researchers have posited that Perceived Consumer Effectiveness (PCE), or the belief that one’s behaviors are efficacious in ameliorating environmental impact, is a more appropriate explanatory variable. Yet, there have been contrasting results regarding the comparative effect of PCE, environmental concern, and intentions on green behavior. To address this question and to better understand the generalizability of the results to multiple cultures, the authors integrate PCE and environmental concern into a theoretical model based on the Theory of Planned Behavior. The results from a meta-analysis consisting of 118 studies, and 813 effect sizes, and 26,968 respondents reveal several key insights. First, cultural characteristics, such as power distance, masculinity, indulgence, and uncertainty moderate the relationship between PCE and green behavior. Second, contrary to prevailing assumptions, both PCE and environmental concern exhibit similar magnitudes in explaining overall green behavior. Third, a model with PCE and environmental concern demonstrates greater explanatory power for green behavior when compared to the traditional Theory of Planned Behavior model. These results offer valuable insights for researchers, managers, non-governmental organizations, and policymakers seeking culturally nuanced guidance to promote consumer green behavior more effectively.
Acute Pancreatitis: An Unusual Side Effect of Adalimumab in Crohn’s Disease Patient
Authors: El Ouardi Walid , Benazzouz Mustapha 
Published: January 2025

Background: Drug-induced acute pancreatitis is a rare condition occurs at an incidence rate of 0.1–1.4% and represents a diagnostic challenge. TNFα inhibitors specially adalimumab is very rarely reported in the literature, primarily through case reports, as a potential cause of acute pancreatitis. Case presentation: Our case report presents a case of a 23-year-old patient followed for Crohn disease in whom a diagnosis of acute pancreatitis induced by adalimumab was made. This diagnosis was confirmed after the elimination of other possible etiologies, and notably by the recurrence of pancreatitis after Adalimumab rechallenge. The occurrence of acute pancreatitis induced by TNFα inhibitors exposes to the risk of pancreatitis with other drugs in this class, hence the need to switch to another therapeutic class, which was Ustekinumab in our case. Conclusion: Acute pancreatitis is an unusual complication of treatment with Adalimumab. Through our experience, based on solid scientific data, we want to draw the attention of clinicians to the reality of this complication. It should be considered in any patient on TNFα inhibitors who presents with acute pancreatitis without an obvious cause.
Comparing the efficacy of 3D-printing-assisted surgery with traditional surgical treatment of fracture: an umbrella review
Authors: Xiao Lin , Tang Peiyuan , Yang Shengwu , Su Jingyue , Ma Wenbo , Tan Han , Zhu Ying , Xiao Wenfeng , Wen Ting , Li Yusheng , Liu Shuguang , Deng Zhenhan 
Published: January 2025

Abstract

Background
The objective of this review is to evaluate the methodological quality of meta-analyses and observe the consistency of the evidence they generated to provide comprehensive and reliable evidence for the clinical use of three-dimensional (3D) printing in surgical treatment of fracture.

Methods
We searched three databases (PubMed, Embase, and Web of Science) up until August 2024. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) standards were adhered to in this review. The Measurement Tool to Assess Systematic Reviews (AMSTAR) 2 was used to rate the quality and reliability of the meta-analyses (MAs), and Grading of Recommendations Assessment, Development, and Evaluation (GRADE) was used to grade the outcomes. Furthermore, Graphical Representation of Overlap for Overviews (GROOVE) was employed to examine overlap, and the resulting evidence was categorized into four groups according to established criteria for evidence classification.

Results
Results from 14 meta-analyses were combined. AMSTAR 2 gave six meta-analyses a high rating, six MAs a moderate rating, and two MAs a low rating. Three-dimensional printing shows promising results in fracture surgical treatment, significantly reducing operation time and loss of blood for tibial plateau fracture. For acetabular fracture, apart from the positive effects on operation time (ratio of mean (ROM) = 0.74, 95% confidence interval (CI), 0.66–0.83, I
2 = 93%) and blood loss (ROM = 0.71, 95% CI 0.63–0.81, I
2 = 71%), 3D printing helps reduce postoperative complications (odds ratio (OR) = 0.42, 95% CI, 0.22–0.78, I
2 = 9%). For proximal humerus fracture, 3D printing helps shorten operation time (weighted mean difference (WMD) = −19.49; 95% CI −26.95 to −12.03; p < 0.05; I
2 = 91%), reduce blood loss (WMD = −46.49; 95% CI -76.01 to −16.97; p < 0.05; I
2 = 98%), and get higher Neer score that includes evaluation of pain, function, range of motion, and anatomical positioning (WMD = 9.57; 95% CI 8.11 to 11.04; p < 0.05; I
2 = 64%). Additionally, positive results are also indicated for other fractures, especially for operation time, blood loss, and postoperative complications.

Conclusions
Compared with traditional fracture surgical treatment, 3D-printing-assisted surgery has significant advantages and great effectiveness in terms of operation time, loss of blood, and postoperative complications in the treatment of many different types of fractures, with less harm to patients.
Assembly and comparative analysis of the complete mitochondrial genome of red raspberry (Rubus idaeus L.) revealing repeat-mediated recombination and gene transfer
Authors: Zhang Huajie , Yan Minghui , Li Lijuan , Jiang Zhuo , Xiong Ye , Wang Yusheng , Akogwu Caleb Onoja , Tolulope Olutayo Mary , Zhou Hao , Sun Yanxia , Wang Hengchang 
Published: January 2025

Abstract

Background
Red raspberry (Rubus idaeus L.) is a renowned fruit plant with significant medicinal value. Its nuclear genome and chloroplast genome (plastome) have been reported, while there is a lack of genetic information on its mitogenome. We sequenced and assembled the complete mitogenome of R. idaeus, and conducted a series of genetic investigations comparing it with the nuclear and chloroplast genomes, so as to better gain a comprehensive understanding of the species’ genetic background.

Results
The mitogenome is represented by one circular chromosome of 438,947 bp. Twenty-four core genes, nine variable genes, 26 tRNAs, and three rRNAs were annotated. A total of 52 SSRs and 38 tandem repeat sequences were identified. 533 pairs of dispersed repeats were detected, among which three pairs were found to have mediated the homologous recombination, resulting in one major conformation and seven minor conformations. Furthermore, 52 homologous sequences between the mitogenome and plastome were identified, including six complete protein-coding genes and 12 tRNA genes. We also detected 828 homologous fragments between the nuclear genome and mitogenome, including one trnM-CAU gene.

Conclusions
In this study, we presented the mitogenome of R. idaeus for the first time based on data obtained from Illumina and Oxford Nanopore sequencing platforms. Key characteristics of the mitogenome were examined, including its gene composition, repetitive elements, and homologous DNA fragments. Additionally, we identified multiple recombination events in the mitogenome mediated by repetitive sequences The high-quality and well-annotated mitogenome for the known fruit red raspberry will provide essential genetic information for species classification, evolution analysis, and even genetic improvement in Rubus in the future.