bluuebunny/crossref_metadata_2025_split huggingface dataset:
Political Will Pemerintahan Kabupaten Banyuasin dalam Meningkatkan Industri Pangan di Kecamatan Tungkal Ilir
Authors: Ramadhan Luthfi Akhiri , Izomiddin Izomiddin , Zalpa Yulion 
Published: February 2023

Pertumbuhan industri pangan berarti peningkatan pasokan yang bertujuan untuk meningkatkan output komoditas pangan dalam negeri. Pangan merupakan kebutuhan paling dasar dalam kehidupan manusia. Salah satu daerah tempat industri pangan di Indonesia berkembang adalah Kabupaten Banyuasin di Sumatera Selatan, terbukti dengan penghargaan yang diterima Bupati Banyuasin (Askolani) yaitu Kategori Ketahanan Pangan Swadaya Indonesia 2020. Di kecamatan Tungkal Ilir merupakan kecamatan yang unggul dalam komoditas sektor perkebunan dan tanaman pangan, beliau juga menambahkan bahwa untuk komoditas tanaman pangan kecamatan Tungkal Ilir termasuk dalam IP200 atau dua kali panen dalam satu tahun. Tentunya dari penghargan tersebut terdapat kemauan politik yang kuat dari Pemkab. Metode yang digunakan dalam penelitian ini adalah metode kualitatif dan deskriptif, yang berjenis penelitian lapangan, sumber data yang dipakai dalam penelitian ini adalah data utama yaitu wawancara, untuk teknik analisis data penulis menggunakan tiga tahap yakni, reduksi data, penyajian data, dan penarikan kesimpulan. Teori yang digunakan adalah teori political willingnes oleh Brinkerhoff yang dikaitkan dengan political will pemerintahan kabupaten banyuasin teori ini mampu menganalisa political will pemerintahan banyuasin dalam meningkatkan industry pangan di kecamatan Tungkal Ilir. Hasil dari penelitian ini menujukan bahwa political will pemerintahan kabupaten Banyuasin dalam meningkatkan industry pangan di kecamatan Tungkal Ilir memiliki berbagai macam cara yang dilakukan, seperti pengeluaran inisiatif berupa penerimaan Petugas Penyuluhan Lapangan (PPL) untuk setiap desa, kemudian dengan bantuan Sarana Produksi (SaProdi). Dilanjutkan dengan pelaksanaan kebijakan politik untuk meningkatkan produksi pangan seperti kebijakan SeRaSi dan juga kebijakan OpLa diperuntukan bagi kecamatan tungkal ilir dan Indonesia secara keseluruhan.
Kata Kunci: Kemauan Politik, Pemerintahan, Pangan
PEMBELAJARAN BERBASIS TIK DI SD IT AL-KHOIRIYAH DALAM PENERAPAN BERBASIS ONLINE
Authors: Harahap Aulia Rika , Prastowo Andi 
Published: February 2023

Abstrak
Penelitian ini bertujuan untuk mengetahui kelebihan dan kekurangan pembelajaran berbasis TIK dalam penerapan berbasis online. Penelitian ini menggunakan metode pendekatan deskriptif dengan perolehan data berdasarkan teknik observasi, wawancara, dan dokumentasi. Adapun teknik analisis data yaitu dengan cara mengumpulkan dokumentasi beberapa sumber penelitian baik jurnal atau buku yang berkaitan dengan judul penelitian, kemudian dianalisis dari beberapa sumber tersebut kemudian ditarik sebuah kesimpulan untuk menguatkan hasil kesimpulan yang akan penulis uraikan dalam penelitian. Berdasarkan hasil penelitian bahwa dalam pembelajaran berbasis TIK dalam penerapan berbasis online menunjukkan bahwa kelebihannya dapat memunculkan gambar atau suara sehingga siswa lebih antusias untuk belajar dan memperbaiki daya ingat peserta didik. Artinya guru mengirim vidio pembelajaran kepada siswa dengan menggunakan aplikasi whatsapp, Dalam belajar baik pengajar maupun pelajar akan lebih mudah mencari sumber karena adanya internet. Pemberian dan penerimaan materi atau tugas tidak harus bertatap muka lagi, dan Menjalin hubungan yang lebih erat antara guru dan orang tua dalam peroses pembelajaran. Sedangkan kekurangannya sering terjadi penyalahgunaan penggunaan handphone misalnya siswa membuka aplikasi yang lain ketika belajar, guru lebih suka menjelaskan secara langsung darikan mengirim tugas ke siswa, siswa bosan belajar di rumah dan senang belajar di sekolah dan orang tua merasa terbebani dengan adanya penerapan pembelajaran berbasis online.
Kata kunci: Kelebihan, Kekurangan, Pembelajaran Online
Return to Work Following Intramedullary Nailing of Lower-Limb Long-Bone Fractures in South Africa
Authors: Masterson Samuel , Laubscher Maritz , Maqungo Sithombo , Ferreira Nando , Held Michael , Harrison William J. , Graham Simon Matthew 
Published: February 2023

Background:
Injuries are one of the leading causes of global death and disability and commonly have substantial economic implications. The economic impact of injuries is particularly pronounced in low- and middle-income countries, where 90% of injuries occur. In this study, we aimed to assess return-to-work rates of individuals who sustained a lower-limb long-bone fracture in South Africa and to identify factors that influence the ability to return to employment.

Methods:
This prospective cohort study was conducted across 2 tertiary trauma centers in Cape Town, South Africa. Adults who received intramedullary nail fixation for a lower-limb fracture between September 2017 and December 2018 were recruited and followed for 18 months postoperatively. The participants’ return to employment was assessed at 6 and 18 months post-injury. Multivariate logistic regression was used to identify factors that influence post-injury employment.

Results:
Of the 194 participants enrolled, 192 completed follow-up. The study population had a median age of 33.0 years, and most of the participants (76.6%) were male. Seventy-five percent of the participants were employed before their injury. At 6 and 18 months post-injury, 34.4% and 56.3% of participants, respectively, were employed. Of those employed pre-injury, 70.1% had returned to work at 18 months. Multivariate regression identified increasing age, unemployment prior to injury, and working in the informal employment sector as factors that impede an individual’s likelihood of working 18 months post-injury. For those in employment prior to injury, increasing age was the only factor found to impede the likelihood of returning to work following an injury.

Conclusions:
This study highlights the profound effect that lower-limb long-bone fractures may have on an individual’s ability to return to work in South Africa, with the potential to cause substantial economic impact on an individual’s livelihood and that of their dependents.

Level of Evidence:
Prognostic Level III. See Instructions for Authors for a complete description of levels of evidence.
Nonunion of an Undisplaced Lateral Compression Type 1 Pelvic Ring Fracture due to Interposition of a Tension-Free Vaginal Tape
Authors: Marti Darius , Heimann Alexander Frank , Hanauer Matthieu , Schwab Joseph M , Laurencon Jonathan , Tannast Moritz 
Published: February 2023

Case:
Nondisplaced lateral compression type 1 fractures of the pelvic ring are usually treated nonoperatively. We describe a case of nonunion after conservative treatment of such a fracture in a healthy 59-year-old female patient due to the interposition of a tension-free vaginal tape in the fracture gap. An anterior intrapelvic approach with plate osteosynthesis was used to stabilize the fracture once the tape was removed from the fracture gap. After 3 months, the fractures had healed and the patient was pain-free.

Conclusions:
Previous urogynecologic interventions should be routinely inquired about and considered in anterior pelvic ring injuries.
Los referentes culturales en las películas de “Shrek”: un estudio de caso sobre las versiones subtituladas y dobladas del inglés al árabe.
Authors: Bouabdellah Omar Bouabdellah 
Published: February 2023

Esta investigación intentará plantear un par de preguntas relacionadas con las estrategias utilizadas en la subtitulación y el doblaje de los referentes culturales del inglés al árabe de la saga de películas de Shrek: Shrek 2, Shrek 3 y Shrek 4., repasaremos las estrategias de la traducción de referentes culturales tal y como fueron propuestas por (Pederson, 2005), así como los factores que podrían afectar a las decisiones del traductor. Asimismo, identificaremos si existen pautas o patrones en la subtitulación y/o el doblaje para este trasvase intercultural. Por otro lado, en el marco de este estudio, quisiéramos probar la hipótesis de si el doblaje es un proceso puramente de domesticación, mientras que la subtitulación es un proceso de extranjerización; un concepto desarrollado por (Venuti, 1995). A este respecto, analizaremos los ejemplos de referentes culturales extraídos de las películas de Shrek y discutiremos al final los resultados alcanzados.Palabras llaves: Traducción audiovisual, referentes culturales, doblaje, subtitulación, árabe
Enseñanza-aprendizaje para la acreditación del idioma inglés según el MCERL en la educación superior ecuatoriana
Authors: Saltos Barberá Magdalena 
Published: February 2023

Los procesos educativos de enseñanza aprendizaje han evolucionado desde tiempo atrás a la par con la tecnología. Debido a este avance tecnológico y la necesidad de comunicarse en un idioma universalmente hablado como lo es el inglés, pretendemos averiguar sí el nivel de idioma inglés que se obtiene en las IES ecuatorianas es equivalente a lo que determina el MCERL; para ello haremos una revisión de los enfoques existentes en la actualidad y plantearemos el uso de los parámetros del MCERL en las certificaciones obtenidas en las IES
Third-wave psychotherapy for caregivers of cancer patients: a scoping review
Authors: Hong Bomi , Yang Sora , Hyeon Sojeong , Kim Sojeong , Lee Jiyeon 
Published: February 2023

Abstract
Background
Cancer caregivers provide extensive support in all aspects of patients' daily lives. It has been reported that a significant proportion of cancer caregivers experience emotional distress. As one way to solve this problem, third-wave psychotherapy, which involves integrating acceptance and mindfulness into cognitive‒behavioral therapy, has been applied to improve caregiver outcomes.
Methods
A scoping review was conducted based on the scoping review guidelines proposed by the Jonna Briggs Institute (JBI). PCC was established to review the third-wave psychotherapies applied with cancer caregivers. The population was caregivers for cancer patients, the concept was 'third-wave psychotherapy,' and the context remained open. English and Korean publications published from 2001 to June 2022 were identified from PubMed, Embase, CINAHL, PsycINFO, Cochrane, Korea Med, and RISS.
Results
A total of 12 studies were included in this scoping review. Mindfulness-based stress reduction (MBSR) was the most frequently applied intervention (n = 5), followed by acceptance and commitment therapy (ACT, n = 3) and mindfulness-based cognitive therapy (MBCT, n = 2). Among the six characteristics of third-wave psychotherapy, ‘mindfulness methods’ were identified in most of the studies (n = 12). Dyadic interventions comprised the majority (n = 9). Interventions using digital techniques such as mobile application/web page (n = 3), telephone (n = 3), and FaceTime (n = 2) have increased since 2017. Depression was the most frequently evaluated outcome (n = 8), followed by anxiety and mindfulness (n = 6 each).
Conclusions
The current review examined available third-wave psychotherapies for cancer caregivers and targeted outcomes. Most of the interventions were dyadic interventions and utilized mindfulness techniques with meditation. Delivery methods were continuously updated with digital technologies. Further RCTs with robust research designs and a synthesis of the results of the trials would provide evidence about how to effectively apply third-wave psychological interventions for cancer caregivers.
ucOCN Inhibits Chondrocyte Hypertrophy and Osteoarthritis Development through GPRC6A/HIF-1α Cascade
Authors: Wang Yan , Du Zhangzhen , Li Xu , Zhang Ke , Qin Qiaozhen , Luo Changyi , Wu Jiamei , Zhang Heyang , Liu Shuirong , Xu Zhenghua , Zheng Jing , Fan Shuli , Zhao Yongqi , Jiang Xiaoxia 
Published: February 2023

Abstract
Osteocalcin (OCN), as a characteristic protein expressed at the mature stage of osteoblasts, plays an important role in crosstalk within the skeletal muscle system. Mature OCN is secreted out of the cell after carboxylation in the endoplasmic reticulum. According to the degree of carboxylation, it can be divided into carboxylated OCN (cOCN) and undercarboxylated OCN (ucOCN). The two forms of proteins exhibit different biological activities, which make their functions more complex than those currently recognized. Many literatures reported that more osteocalcin was expressed in the hypertrophic stage of chondrocytes, even as a marker protein of osteoarthritis (OA) chondrocytes. However, these studies paid few attention to the potential different roles of different carboxylated forms of OCN in chondrocytes. Here, we discovered that ucOCN played a significant protecting role in OA development. In OCN knockout (OCN-/-) mice, articular chondrocytes showed a hypertrophic tendency. But in mice OA model, OCN-/- mice didn’t develop more severe OA than WT mice. Meanwhile, OCN in chondrocytes increased significantly and ucOCN in synovial fluid decreased dramatically in WT mice. We hypothesized that intracellular OCN and extracellular ucOCN may play different roles in the development of OA. By manipulating the amount of ucOCN in the synovial fluid in wild type mice and a series of experiments in vitro, we confirmed the protective effect of ucOCN in OA. We further explored the downstream pathway of ucOCN in chondrocytes and verified that ucOCN activates HIF-1α pathway through G protein coupled receptor 6A (GPRC6A) to inhibit chondrocyte hypertrophy.
Novel epigenetic based differentiation therapy for Acute Myeloid Leukemia
Authors: José-Enériz Edurne San , Gimenez-Camino Naroa , Rabal Obdulia , Garate Leire , Miranda Estibaliz , García Fernando , Sáez Elena , Vilas-Zornoza Amaia Amaia , Martín-Uriz Patxi San , Valcárcel Luis V. , Tamariz-Amador Esteban , Alfonso-Pierola Ana , Martinez-Calle Nicolás , Larráyoz María , Calasanz Maria-Jose , Muñoz Javier , Martin-Subero Jose Ignacio , Pineda Antonio , Oyarzabal Julen , Agirre Xabier , Prosper Felipe 
Published: February 2023

Abstract

Despite the development of novel therapies for acute myeloid leukemia (AML), outcomes remain poor for most patients, and therapeutic improvements are an urgent unmet need. Although treatment regimens promoting differentiation have succeeded in the treatment of acute promyelocytic leukemia (APL), their role in other AML subtypes needs to be explored. Here we identified and characterized two lysine (K) deacetylase inhibitors (DACi), CM-444 and CM-1758, exhibiting capacity to promote myeloid differentiation in all AML subtypes at low non-cytotoxic doses unlike other commercial HDACi. Analyzing the acetylome after CM-444 and CM-1758 treatment revealed modulation of non-histone proteins involved in the enhancer–promoter chromatin regulatory complex, including bromodomain proteins (BRDs). This acetylation was essential for enhancing the expression of key transcription factors directly involved in the differentiation therapy induced by CM-444/CM-1758 in AML. In summary, these compounds may represent effective differentiation-based therapeutic agents across AML subtypes with a novel mechanism for treatment of AML.
Encephalartos villosus and Vigna unguiculata L. (Walp) shared symbionts contribute to V. unguiculata plant nutrition and growth in nutrient-deficient ecosystems
Authors: Motsomane Nqobile , Suinyuy Terence , Magadlela Anathi 
Published: February 2023

Abstract
Cycads are ancient plants that establish symbiotic associations with plant growth-promoting (PGP) microbes. These ancient associations are rarely contrasted with more recent associations involving PGP microbes and legumes. This study investigated if V. unguiculata growing in Encephalartos villosus acidic, and nutrient-deficient rhizosphere and surrounding soils may share similar symbionts. In addition, the biomass accumulation and plant nutrition in V. unguiculata growing in these soils was investigated. Vigna unguiculata seeds were grown in E. villosus rhizosphere and surrounding soils for 45 days. Thereafter, growth characteristics and plant nutrition were calculated. Vigna unguiculata plants grown in E. villosus rhizosphere and surrounding soils were nodulated by Paenibacillus, Bacillus, Peribacillus, Brevibacillus, Alkalihalobacillus, and Lysinibacillus species that were also identified in E. villosus coralloid roots. There were no significant differences in the total plant biomass, however, V. unguiculata plants in rhizosphere and surrounding soils invested more resources in belowground biomass. The findings of this study show that V. unguiculata and E. villosus growing in similar soil conditions may share the same symbionts promoting plant nutrient assimilation and growth.
Application of a novel Deep Eutectic Solvent as a capable and new catalyst for the synthesis of tetrahydropyridines and 1,3-thiazolidin-4-ones
Authors: Goodarzi Hadis , Habibi Davood , Monem Arezo 
Published: February 2023

Abstract
A novel Deep Eutectic Solvent (ETPP-Br/THF-TCA-DES) was prepared by a mixture of ethyl triphenylphosphonium bromide (MTPP-Br) and tetrahydrofuran-2,3,4,5-tetra-carboxylic acid (THF-TCA, mole ratio 7:3) in a cheap, simple, and non-toxic method, characterized by FT-IR, TGA/DTA, densitometer, eutectic point, and 1H NMR techniques and used as a capable and new catalyst for the synthesis of two sets of compounds: i) the four new [a(1-4)] and the ten [a(5-15)] known alkyl 1,2,6-trisubstituted-4-[(hetero)arylamino]-1,2,5,6-tetrahydropyridine-3-carboxyl-ates, and ii) the two new [b(1-2)] and the eight [b(3-10)] known 1,3-thiazolidin-4-ones in solvent-free conditions, short reaction time, high yields, and easy recycling and separation of the DES catalyst.
There is a nice consistency between the proposed structure of the DES compound, the integration values of the 1H NMR peaks and the ratio of ETPP-Br to THF-TCA obtained from the eutectic point phase diagram.
Also, the decrease in splitting patterns of the peaks in DES, compared to the two starting materials can be a good evidence of hydrogen bond formation between the two components.
Thematic analysis of national online narratives on regular asymptomatic testing in schools in the United Kingdom
Authors: Taylor-Egbeyemi Jo , Carter Holly , Robin Charlotte 
Published: February 2023

Abstract
Objective: To understand the public perceptions of the schools testing programme in England.
Design: Qualitative social media analysis.
Setting: Online users of parenting forums (Mumsnet and Netmums), Facebook and Daily Mail online readers, who responded to randomly selected posts or articles about the schools testing programme in England, between 1 and 31 March, 2021.
Results: Overall, seven main themes were identified, these were divided into barriers and facilitators to engaging in testing. Barriers were: uncertainty around testing in the absence of symptoms; concerns about testing; concern about testing positive; mistrust in the Government. Facilitators were: desire to protect others; desire to return to normality; and hearing others’ positive experiences.
Conclusions: Our analysis highlighted that alongside well-established barriers to engaging in asymptomatic testing, parents were having to negotiate additional complex decisions around balancing their child’s anxiety over testing alongside acknowledgement of the implications of regular testing, such as return to normality and protecting others. Parents and children would benefit from additional practical and social support to facilitate engagement with the schools testing programme.
Transcriptomic analysis reveals the mechanism underlying the anthocyanin changes in Fragaria nilgerrensis Schlecht. and its interspecific hybrids
Authors: Wang Ai-Hua , Ma Hong-Ye , Zhang Xing-Tao , Zhang Bao-Hui , Li Fei 
Published: February 2023

Abstract
Background: Fragaria nilgerrensis (FN) provides a rich source of genetic variations for strawberry germplasm innovation. The coloration of strawberry fruits is a critical factor affecting consumer preferences. However, the genetic basis of the fruit color formation in F. nilgerrensis and its interspecific hybrids has rarely been researched.
Results: In this study, the fruit transcriptomes and flavonoid contents of FN (white skin; control) and its interspecific hybrids BF1 and BF2 (pale red skin) were compared. A total of 31 flavonoids were identified. Notably, two pelargonidin derivatives (pelargonidin-3-O-glucoside and pelargonidin-3-O-rutinoside) were revealed as potential key pigments for the coloration of BF1 and BF2 fruits. Additionally, DFR (LOC101293459 and LOC101293749) and BZ1 (LOC101300000), which are crucial structural genes in the anthocyanidin biosynthetic pathway, had significantly up-regulated expression levels in the two FN interspecific hybrids. Moreover, most of the genes encoding transcription factors (e.g., MYB, WRKY, TCP, bHLH, AP2, and WD40) related to anthocyanin accumulation were differentially expressed. We also identified two DFR genes (LOC101293749 and LOC101293459) that were significantly correlated with bHLH, MYB, WD40, AP2, and bZIP transcription factors. Two CHS genes (LOC101298162 and LOC101298456) and a BZ1 gene (LOC101300000) were highly correlated with bHLH, WD40, and AP2 transcription factors.
Conclusions: Pelargonidin-3-O-glucoside and pelargonidin-3-O-rutinoside may be the key pigments contributing to the formation of pale red fruit skin. DFR and BZ1 structural genes and some bHLH, MYB, WD40, AP2, and bZIP TF family members enhance the accumulation of two pelargonidin derivatives. This study provides important insights into the regulation of anthocyanidin biosynthesis inFN and its interspecific hybrids. The presented data may be relevant for improving strawberry fruit coloration via genetic engineering.
Initial End-to-End testing of the ExacTrac Dynamic Deep Inspiration Breath Hold workflow using a breath hold breast phantom
Authors: Goodall Simon , Rampant Peter L 
Published: February 2023

Abstract
The ExacTrac Dynamic (ETD) system provides a Deep Inspiration Breath Hold (DIBH) workflow for treatment of left sided breast patients. Combined stereoscopic x-ray imaging with optical and thermal mapping allows localisation against simulation imaging, alongside surface guided breath hold monitoring. This work aimed to determine appropriate x-ray breast imaging parameters, optimal Hounsfield Unit (HU) values for patient contour generation and workflow evaluation via end-to-end (E2E) positioning testing. After phantom localisation via existing Image Guidance (IG), stereoscopic imaging was performed with a range of parameters to determine minimal residual error. Similarly, residual errors in prepositioning were minimised using a range of HU value external contours. E2E positioning was completed for clinical workflows and residual positioning error was measured using treatment field deviations and existing IG. Parameters of 60 kV and 25mAs were determined appropriate for patient imaging and HU values between -600 HU and 200 HU enabled adequate prepositioning. The average residual position error measured using treatment fields was 1.0 ± 0.9 mm, 0.4 ± 1.0 mm and 0.1 ± 0.5 mm in the lateral, longitudinal and vertical directions, respectively. Errors measured using existing IG were -0.6 ± 1.1 mm, 0.5 ± 0.7 mm and 0.2 ± 0.4 mm in the lateral, longitudinal and vertical directions, and rotational errors averaged of 0.0 ± 1.0 o, 0.5 ± 1.7 o and -0.8 ± 1.8o for pitch roll and yaw, respectively. The use of bone weighted matching increased residual error. A reduction of phantom DIBH volume maintained target positioning accuracy.