bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tuberculous Meningitis Complicated With Deep Sylvian Cerebral Infarction: About an Immunocompetent Patient With HIV-AIDS
Authors: Tanoh Muriel Amon , Aka Arlette Désirée , Tanoh Christian Abel , Diakité Ismaïla , Ehounoud Constance Yapo- , Kadjo Cédric , de Souza Nancy Ahya Essoin , Aka-Diarra Evelyne , Assi Berthe 
Published: September 2023

Abstract
INTRODUCTION Neuromeningeal tuberculosis is the most common form of extra-pulmonary tuberculosis in developing countries. It is the most serious form of Mycobacterium tuberculosis infection. Vascular complications of tuberculous meningitis involve functional prognosis of patients.OBSERVATION In our daily practice, we frequently encounter cases of cerebral infarction associated with neuromeningeal tuberculosis in the infectious etiological balance. We report the case of an HIV immunocompetent patient hospitalized for neuromeningeal tuberculosis complicated with ischemic stroke. It was a 39-year-old patient, right-handed, admitted to the Neurology department of University Hospital of Cocody in whom the diagnosis of neuromeningeal tuberculosis was retained. She received treatment for tuberculosis in emergency. On the seventh day of hospitalization, she suddenly presented with a massive motor deficit of the left hemibody. The MRI performed was compatible with meningoencephalitis associated with recent deep right Sylvan ischemia foci. The evolution was marked by partial recovery of the left hemiplegia, right retro-bulbar neuritis, and iatrogenic hepatic cytolysis.COMMENTS Tuberculous meningitis remains today one of the most serious neurological conditions involving the vital and functional prognosis of patients. Association of cerebral infarction and tuberculous meningitis is of variable occurrence. There are reported cases in which cerebral infarction is a complication of tuberculous meningitis. On the other hand, the discovery of tuberculous meningitis can be observed in the assessment of a cerebral infarction in young subjects. Tuberculous meningovascularitis remains a rare condition in immunocompetent patients for HIV-AIDS. It results from arterial occlusion by thrombosing and obliterating endarteritis. It represents a medical emergency requiring starting anti-tuberculosis treatment. The evolution depends on the precocity of the diagnosis and the speed of treatment.CONCLUSION The sudden appearance of a neurological deficit in à patient with tuberculous meningitis even under specific treatment should suggest an ischemic stroke, especially if the symptomatology respects an anatomo-functional vascular systematization.
MIM-CyCIF: Masked Imaging Modeling for Enhancing Cyclic Immunofluorescence (CyCIF) with Panel Reduction and Imputation
Authors: Chang Young Hwan , Sims Zachary , Mills Gordon 
Published: September 2023

Abstract
CyCIF can quantify multiple biomarkers, but panel capacity is limited by technical challenges. We propose a computational panel reduction approach that can impute the information content from 25 markers using only 9 markers, learning co-expression and morphological patterns while concurrently increasing speed and panel content and decreasing cost. We demonstrate strong correlations in predictions and generalizability across breast and colorectal cancer, illustrating applicability of our approach to diverse tissue types.
Balancing Resistor-based Online Electrochemical Impedance Spectroscopy: Opportunities and Limitations
Authors: Blömeke Alexander , Zappen Hendrik , Ringbeck Florian , Wasylowski David , Sauer Dirk Uwe 
Published: September 2023

Abstract
Active dissipative balancing systems are widely used in battery systems. A lower boundary for the necessary balancing current is the difference in the leakage current of batteries in the system. The use of balancing resistors for the excitation of lithium-ion battery cells to determine their impedance has been discussed for almost decades. The value of impedance spectroscopy for in-depth battery cell diagnostics, such as temperature or aging, is currently being demonstrated and recognized by vehicle manufacturers, chip producers, and academia. This work systematically and quantitatively investigates how and under which circumstances the excitation can be performed via the balancing resistors already used in the battery management system and where limitations may lie. If individual cells or modules are to be replaceable, the balancing current must be so high that it can also be used for online electrochemical impedance spectroscopy.
A prognostic matrix code defines functional glioblastoma phenotypes and niches
Authors: Korkut Anil , Vishnoi Monika , Dereli Zeynep , Yin Zheng , Kong Elisabeth , Kinali Meric , Thapa Kisan , Babur Ozgun , Yun Kyuson , Abdelfattah Nourhan , Li Xubin , Bozorgui Behnaz , Rostomily Robert 
Published: September 2023

Abstract
Interactions among tumor, immune and vascular niches play major roles in driving glioblastoma (GBM) malignancy and treatment responses. The composition, heterogeneity, and localization of extracellular core matrix proteins (CMPs) that mediate such interactions, however, are not well understood. Here, we characterize functional and clinical relevance of genes encoding CMPs in GBM at bulk, single cell, and spatial anatomical resolution. We identify a “matrix code” for genes encoding CMPs whose expression levels categorize GBM tumors into matrisome-high and matrisome-low groups that correlate with worse and better patient survival, respectively. The matrisome enrichment is associated with specific driver oncogenic alterations, mesenchymal state, infiltration of pro-tumor immune cells and immune checkpoint gene expression. Anatomical and single cell transcriptome analyses indicate that matrisome gene expression is enriched in vascular and leading edge/infiltrative anatomic structures that are known to harbor glioma stem cells driving GBM progression. Finally, we identified a 17-gene matrisome signature that retains and further refines the prognostic value of genes encoding CMPs and, importantly, potentially predicts responses to PD1 blockade in clinical trials for GBM. The matrisome gene expression profiles provide potential biomarkers of functionally relevant GBM niches that contribute to mesenchymal-immune cross talk and patient stratification which could be applied to optimize treatment responses.
Absorbent Hygiene Products Disposal Behaviour in Informal Settlements: Identifying Determinants and Underlying Mechanisms in Durban, South Africa
Authors: Slekiene Jurgita , Swan Nick , Kalina Marc 
Published: September 2023

Abstract
Background: Within South Africa, many low-income communities lack reliable waste management services. Within these contexts, absorbent hygiene waste (AHP) waste, including nappies (diapers), are not recycled, and are often dumped, ending up in watercourses and polluting the local environment. The structural barriers to collection which have been well explored, however the behavioural determinants of safe disposal for AHPs remains poorly understood, in South Africa, and in low-income contexts. The purpose of this study is to determine the psycho-social factors driving AHP disposal behaviour for mothers and caregivers, while identifying potential underlying mechanisms (such as mental health), which may be influencing disposal behaviour, with the intention of informing a future, contextually appropriate and sustainable, collection system.
Methods: The cross-sectional study was conducted within three purposively selected low-income communities (Johanna Road, Blackburn, and Mzinyathi), located within eThekwini Municipality (Durban), South Africa. The study included a qualitative pre-study (N=30) and a quantitative survey of 452 mothers and caregivers, utilise the RANAS approach of behaviour change. The quantitative questionnaire was based on the RANAS model to measure psycho-social factors underlying sanitary disposal of AHPs. Mental health was assessed using the Self-Reporting Questionnaire (SRQ-20). Results: Our findings suggest that one third of caregivers do not dispose of nappies sanitarily, despite intent (86.9%). Regression analysis revealed ten psycho-social factors which significantly predict the desired behavioural outcome, the sanitary disposal of AHPs. Moreover, caregivers with poor mental health were less likely to dispose of AHP sanitarily, which reflects previous research linking poor mental health and the impairment of health-related daily activities, particularly within vulnerable groups. Specifically, several psychosocial factors underlying were moderated by poor mental health, the prevalence of sanitary disposal of AHPs depended on mental condition of caregiver.
Conclusions: Our findings confirmed the link between poor mental health and unsanitary AHP’s disposal. This is especially relevant because poor mental health is common within South Africa. Addressing mental health problems within these communities is an essential step to providing sustainable waste management services. The findings should inform an intervention strategy to implement a future collection system for these communities, and similar low-income or informal contexts within South Africa.
Obtaining auxetic and isotropic metamaterial in counterintuitive
design spaces: An automated optimization approach and experimental characterization
Authors: Grigoropoulos Costas , Meier Timon , Li Runxuan , Mavrikos Stefanos , Blankenship Brian , Vangelatos Zacharias , Yildizdag M. Erden 
Published: September 2023

Abstract
Recent advancements in manufacturing, finite element analysis (FEA), and optimization techniques have expanded the design possibilities for metamaterials, including isotropic and auxetic structures, known for applications like energy absorption due to their unique deformation mechanism and consistent behavior under varying loads. However, achieving simultaneous control of multiple properties, such as optimal isotropic and auxetic characteristics, remains challenging. This paper introduces a systematic design approach that combines modeling, FEA, neural networks, and optimization to create targeted mechanical behavior in metamaterials. Through strategically arranging 8 distinct neither isotropic nor auxetic unit cell states, the stiffness tensor in a 5 × 5 × 5 cubic symmetric lattice structure is controlled. Employing the NSGA-II genetic algorithm and automated modeling, we yield metamaterial lattice structures possessing both, desired isotropic and auxetic properties. Multiphoton lithography fabrication and experimental characterization of the optimized metamaterial highlights a practical real-world use and confirms close correlation between theoretical and experimental data.
The Optimization of Mixed Physical Education Teaching Mode in High-order Complex Network Environment
Authors: Zhang Chaonan 
Published: September 2023

Abstract
This paper aims to improve the utilization rate of educational resources and optimize the learning effect through the mixed Physical Education (PE) mode in the high-order Complex Network (CN) environment. In the high-order CN environment, the design scheme of mixed teaching mode is proposed based on various PE teaching modes. Additionally, the dynamic structure of the network topology is further established by formulating the research plan and determining the type weights of boundary points. To optimize the complex interaction between micro and macro behaviors, Sparse Code Multiple Access and Low Density Signature are selected to optimize the transmission and processing efficiency of teaching resources and expand the channel data transmission capacity. Meanwhile, the Convolutional Neural Network model combining the Internet of Things and machine learning is used to comprehensively analyze and simulate the high-order CN environment. Finally, a teaching evaluation and feedback mechanism is established. The actual situation of PE teaching of college students is used as the research data source. The teaching effect and learner satisfaction are monitored and feedback by setting up the experimental group and control group of the teaching mode of the research object. Through the evaluation results, teaching strategies and methods are timely adjusted, and teaching mode is optimized and improved. The results show that the mixed PE mode can improve learners' learning interest and effect compared with traditional teaching and online teaching. Compared with the traditional teaching mode, students' participation in classroom activities can be increased by 15.2%, and the utilization efficiency of educational resources can be increased by 7.8%. In addition, the establishment of teaching evaluation and feedback mechanisms is very important to optimize the mixed PE teaching model. Therefore, the establishment of teaching evaluation and feedback mechanism can help teachers adjust teaching strategies and methods timely to improve teaching effectiveness and learner satisfaction. This paper provides a useful reference for in-depth discussion on education and teaching optimization.
Sound-based diagnosis of failure in a vertical roller mill.
Authors: Daniel Lamartine Lincoln Neves , Leite Diego Fernandes Queiroga , Gomes Amanda Caroline Alves , Mishina Koje Daniel Vasconcelos , Rodrigues Marcelo Cavalcanti 
Published: September 2023

Abstract

The vertical roller mill used in the cement industry is a large piece of equipment that works without interruption and is essential in production. Due to the occurrence of several breakdowns of its components, mainly the roller ends that caused several production stops, the idea of analyzing the vibrations of the mill to identify a possible defect pattern arose. Sound analysis was performed during a period of terminal failures. The application of signal processing techniques such as FFT, multiresolution analysis, and SAC-DM (chaos theory) allowed the observation of a pattern of equipment behavior that preceded the appearance of failure in the vertical mill's roller terminals. It was observed that the multiresolution analysis and the SAC-DM were sensitive to these patterns, allowing the company's maintenance sector to prepare for repairs.
Divergence of variant binding/neutralizing antibodies following SARS-CoV-2 booster vaccines in myeloma: Impact of hybrid immunity
Authors: Suthar Mehul , Moreno Alberto , Manning Kelly , Azeem Maryam , Nooka Ajay , Ellis Madison , Manalo Renee , Switchenko Jeffrey , Wali Bushra , Kaufman Jonathan , Hofmeister Craig , Joseph Nisha , Lonial Sagar , Dhodapkar Kavita , Dhodapkar Madhav 
Published: September 2023

Abstract
We characterized virus-neutralization and spike-binding antibody profiles in myeloma patients following monovalent or bivalent-SARS-CoV-2 booster vaccination. Vaccination improves the breadth of binding antibodies but not neutralization activity against current variants. Hybrid immunity and immune imprinting impact vaccine-elicited immunity.
Enhancing the forensic sexual assault investigations with LAMP- based male DNA detection
Authors: Chunkul Sunita , Sathirapatya Tikumphorn , Vongpaisarnsin Kornkiat , Dangklao Piyawan , Kawicha Praphat , Tammachote Rachaneekorn 
Published: September 2023

Abstract
Sexual assault is a terrible crime that necessitates a thorough and qualified investigation to collect the perpetrator's biological material. Forensic investigation is required as soon as possible to gather all possible physical and biological evidence. The primary focus of such investigations is the detection of male-specific materials, particularly sperm in semen stains. Advances in DNA-based testing now allow for on-site analysis at crime scenes. In this study, we developed an assay using the loop-mediated isothermal amplification (LAMP) technique to detect male DNA. The assay underwent validation following the SWGDAM guidelines and was subsequently tested on 92 casework samples from sexual assault cases. To evaluate its performance, we compared the results of three different tests: acid phosphatase, microscopic examination, and the LAMP assay, against the Y-STR profiling results. Findings from this study demonstrate the high efficiency of the LAMP assay when compared to Y-STR profiling. These results highlight the potential of the LAMP technique as a valuable tool for male DNA detection in forensic casework. Further research and validation studies are necessary to fully explore its practical applications and enhance its utility in criminal investigations.
What works in radiology education for medical students: A systematic review and meta-analysis
Authors: Wade Stuart W.T. , Velan Gary M. , Tedla Nicodemus , Briggs Nancy , Moscova Michelle 
Published: September 2023

Abstract
Background: Medical imaging related knowledge and skills are widely used in clinical practice. However, radiology teaching methods and resultant knowledge among medical students and junior doctors is variable. A systematic review and meta-analysis was performed to compare the impact of different components of radiology teaching methods (active versus passive teaching, eLearning versus traditional face to face teaching) on radiology knowledge / skills of medical students.
Methods: PubMed and Scopus databases were searched for articles published in English over a 15-year period ending in June 2021 quantitatively comparing the effectiveness of undergraduate medical radiology education programs regarding acquisition of knowledge and/or skills. Study quality was appraised by the Medical Education Research Study Quality Instrument (MERSQI) scoring and analyses performed to assess for risk of bias. A random effects meta-analysis was performed to pool weighted effect sizes across studies and I2 statistics quantified heterogeneity. A meta-regression analysis was performed to assess for sources of heterogeneity.
Results: From 3,052 articles, 40 articles involving 6,242 medical students met inclusion criteria. Median MERSQI score of the included articles was 13 out of 18 possible with moderate degree of heterogeneity (I2 = 93.42%). Thematic analysis suggests trends toward synergisms between radiology and anatomy teaching, active learning producing superior knowledge gains compared with passive learning and eLearning producing equivalent learning gains to face-to-face teaching. No significant differences were detected in the effectiveness of methods of radiology education.
Conclusions: Studies of educational interventions are inherently heterogeneous and contextual, typically tailored to specific groups of students. Thus, we could not draw definitive conclusion about effectiveness of the various radiology education interventions based on the currently available data. More consistent approaches to design and implementation of educational interventions in radiology are needed to understand aspects of educational design and delivery that are optimal for learning.
Trial registration: Prospero registration number CRD42022298607.
The microenvironment resulting from the co-culture of human amniotic fluid-derived mesenchymal stem cells with peripheral blood mononuclear cells differs between type 1 diabetes mellitus patients and healthy individuals
Authors: Hoseini Seyed Mehdi , Moghimi Farnoosh , Hosseini Elham Sadat , Miresmaeili Seyed Mohsen , Mehrjardi Mohammad Yahya Vahidi , Dehghani Mohammad Reza , Sheikhha Mohammad Hasan , Montazeri Fateme 
Published: September 2023

Abstract
IFNγ is one of the main factors involved in type 1 diabetes (T1D) pathogenesis and has also been used to license mesenchymal stem cells (MSCs) for displaying immunosuppressive properties in a process termed preconditioning/priming. Our study aimed to investigate the interaction of amniotic fluid-derived MSCs (AF-MSCs) in two preconditioned (IFNγ⁺) and non-preconditioned (IFNγ⁻) conditions, with peripheral blood mononuclear cells (PBMCs) from the sources of healthy control (HC) and T1D. Accordingly, the interactions were assessed through anti-inflammatory genes, chemokines and their receptors, plus the induction of T regulatory (Treg) cells. Our results demonstrated that MSC/IFNγ⁺ and MSC/IFNγ⁻ treatments respond conversely to HC and T1D PBMCs regarding the expression of anti-inflammatory genes (IDO1, IDO2, ICAM-1), chemokine ligands (CCL3, CXCL9, CXCL10) and receptors involved in immune cell trafficking (CXCR3, CXCR6, TLR4). Our findings also confirmed the same opposite effects of HC and T1D PBMCs when interacting with IFNγ⁺ and IFNγ⁻ MSCs regarding the expression of target genes, including CXCR3 and its ligands (CXCL9 and CXCL10), CXCR6, CCR5 and its ligands (CCL3 and CCL4). These differences were also reflected in the proportion of Treg cells in HC and T1D samples, depending on whether it was assessed through paracrine or cell contact approaches. Our research indicates that the interaction between IFNγ⁺ and IFNγ⁻ MSCs and T1D PBMCs creates distinct microenvironments compared to those in HC PBMCs. This implies that the intravenous administration of MSCs into T1D patients may result in different outcomes than in healthy individuals that can be manipulated by the preconditioning of MSCs.
Numerical Simulation and Experimental Study on Axial Compression Electromagnetic Bulging of Aluminum Alloy Tube
Authors: Wang Dahao , Zhu Zhenyu , Pan Fei , Sun Xiaoming , Cui Xiaohui , Fang Jinxiu 
Published: September 2023

Abstract
Aiming at the problem of a small area at the end of the tube and the asynchronous rate of traditional mechanical forming and electromagnetic forming, a new technology of axial compression electromagnetic bulging is proposed with 5052 aluminum alloy tube. In this study, multiple sets of electromagnetic coils are arranged. At the moment of discharge, the radial electromagnetic force generated by the bulging coil bulges the tube, and meanwhile, the booster coil generates axial magnetic force at the end of the tube, which axial feeding the material in time. Based on multi-physical field element simulation and experimental study, the influence of main process parameters on uniform tube bulging is analyzed, and it is revealed that the axial magnetic force produced by the booster coil at the end of the tube is the main factor to improve the plastic deformation ability of the tube in the process of axial compression electromagnetic bulging, the principal stress of typical point changes from biaxial tensile stress state to one tension one compression state, and the proportion of compressive stress is increased, thus the forming limit is increased.
Sensitivity evolution in Venturia inaequalis towards SDHIs in comparison to other modes of action
Authors: Hoffmeister Mascha , Scheu Patrycja , Huf) Anna Glaab (forml. , Zito Raffaello , Stammler Gerd 
Published: September 2023

Abstract
Succinate dehydrogenase inhibitors (SDHIs) are an important group of fungicides (FRAC Group 7) for the control of Venturia inaequalis. Mechanisms which lead to reduced SDHI sensitivity in fungi are based on mutations in the SDH-subunits B, C, or D of the target gene. Monitoring studies have shown that most of the European population is still sensitive to SDHIs. Single cases of SDHI resistance have been detected shortly after market introduction although mainly at trial sites. The underlying resistance mechanisms have been identified as target site mutations (B-T258I, C-N85S and C-H151R). However, these were single findings which did not increase in frequency or even disappeared when the same field was analyzed one or more seasons later. This is in contrast to findings on other resistance cases which are stable over several seasons even without selection pressure, such as QoI and benzimidazole resistance. High frequencies of target site mutations for QoIs and benzimidazoles (G143A and E198A, respectively) have been detected in a 2022 survey, whereas no SDHI target site mutation exceeded the detection limit of our molecular detection assay in any sample.