bluuebunny/crossref_metadata_2025_split huggingface dataset:
Excited‐State Dynamics in All‐Polymer Blends with Polymerized Small‐Molecule Acceptors
Authors: Liu Ziran , Li Qian , Fu Lulu , Wang Jide , Ma Jing , Zhang Chunfeng , Wang Rui 
Published: June 2023

AbstractPolymerizing small‐molecular acceptors (SMAs) is a promising route to construct high performance polymer acceptors of all‐polymer solar cells (all‐PSCs). After SMA polymerization, the microstructure of molecular packing is largely modified, which is essential in regulating the excited‐state dynamics during the photon‐to‐current conversion. Nevertheless, the relationship between the molecular packing and excited‐state dynamics in polymerized SMAs (PSMAs) remains poorly understood. Herein, the excited‐state dynamics and molecular packing are investigated in the corresponding PSMA and SMA utilizing a combination of experimental and theoretical methods. This study finds that the charge separation from intra‐moiety delocalized states (i‐DEs) is much faster in blends with PSMAs, but the loosed π–π molecular packing suppresses the excitation conversion from the local excitation (LE) to the i‐DE, leading to additional radiative losses from LEs. Moreover, the increased aggregations of PSMA in the blends decrease donor: acceptor interfaces, which reduces triplet losses from the bimolecular charge recombination. These findings suggest that excited‐state dynamics may be manipulated by the molecular packing in blends with PSMAs to further optimize the performance of all‐PSCs.
The Conserved LncRNA DIO3OS Restricts Hepatocellular Carcinoma Stemness by Interfering with NONO‐Mediated Nuclear Export of ZEB1 mRNA
Authors: Hou Ya‐Rui , Diao Li‐Ting , Hu Yan‐Xia , Zhang Qian‐Qian , Lv Guo , Tao Shuang , Xu Wan‐Yi , Xie Shu‐Juan , Zhang Qi , Xiao Zhen‐Dong 
Published: June 2023

AbstractHepatocellular carcinoma (HCC) is an aggressive and fatal disease caused by a subset of cancer stem cells (CSCs). It is estimated that there are approximately 100 000 long noncoding RNAs (lncRNAs) in humans. However, the mechanisms by which lncRNAs affect tumor stemness remain poorly understood. In the present study, it is found that DIO3OS is a conserved lncRNA that is generally downregulated in multiple cancers, including HCC, and its low expression correlates with poor clinical outcomes in HCC. In in vitro cancer cell lines and an in vivo spontaneous HCC mouse model, DIO3OS markedly represses tumor development via its suppressive role in CSCs through downregulation of zinc finger E‐box binding homeobox 1 (ZEB1). Interestingly, DIO3OS represses ZEB1 post‐transcriptionally without affecting its mRNA levels. Subsequent experiments show that DIO3OS interacts with the NONO protein and restricts NONO‐mediated nuclear export of ZEB1 mRNA. Overall, these findings demonstrate that the DIO3OS‐NONO‐ZEB1 axis restricts HCC development and offers a valuable candidate for CSC‐targeted therapeutics for HCC.
Opening the Bandgap of Metallic Half‐Heuslers via the Introduction of d–d Orbital Interactions
Authors: Li Airan , Brod Madison K. , Wang Yuechu , Hu Kejun , Nan Pengfei , Han Shen , Gao Ziheng , Zhao Xinbing , Ge Binghui , Fu Chenguang , Anand Shashwat , Snyder G. Jeffrey , Zhu Tiejun 
Published: June 2023

AbstractHalf‐Heusler compounds with semiconducting behavior have been developed as high‐performance thermoelectric materials for power generation. Many half‐Heusler compounds also exhibit metallic behavior without a bandgap and thus inferior thermoelectric performance. Here, taking metallic half‐Heusler MgNiSb as an example, a bandgap opening strategy is proposed by introducing the d–d orbital interactions, which enables the opening of the bandgap and the improvement of the thermoelectric performance. The width of the bandgap can be engineered by tuning the strength of the d–d orbital interactions. The conduction type and the carrier density can also be modulated in the Mg1‐xTixNiSb system. Both improved n‐type and p‐type thermoelectric properties are realized, which are much higher than that of the metallic MgNiSb. The proposed bandgap opening strategy can be employed to design and develop new half‐Heusler semiconductors for functional and energy applications.
DeepMaizeNet: A novel hybrid approach based on CBAM for implementing the doubled haploid technique
Authors: Ayaz Ibrahim , Kutlu Fatih , Cömert Zafer 
Published: June 2023

AbstractMaize (Zea mays L.) is an important cereal plant in the family of wheatgrass cultivated all over the world. With the increase in human population and environmental factors, the need for maize plants is increasing day by day. One of the efficient methods of increasing production of the maize is maize breeding. The most effective and rapid method for maize breeding is the doubled haploid (DH) technique. This technique reduces maize breeding time and increases productivity. There are different selection methods to select haploid maize seeds in the maize breeding process. Among these selection methods, the most common and most successful selection method is the visual checking of the R1‐Navajo marker. Maize seed separation by hand is a time‐consuming and error‐prone operation. It is labor‐intensive and very tiring; therefore, it is essential to develop a fast and highly accurate intelligent system that separates diploid and haploid maize seeds from each other. This study presents a pioneering approach, introducing the DeepMaizeNet, a hybrid deep learning model that showcases its prowess in accurately classifying haploid maize seeds. The classification of haploid seeds holds significant value for the DH technique, and the proposed model's success is a promising step toward enhanced efficiency. The proposed hybrid model exploits some new techniques such as convolution block attention module, hypercolumn, 2D upsampling, and residual block. For the assessment of the proposed model, the five‐fold cross‐validation technique is employed. The result shows that DeepMaizeNet provides a promising performance by achieving 94.13% accuracy, 94.91% F1‐score, and 97.27% sensitivity.
A grassroots antiracist program: The motivation and perceived growth of participants in a community‐based, intergroup dialogue program
Authors: Marcucci Olivia , Roberston Tiffany , Morgan Donald , Lazarus Elizabeth , Mitchell Lisa 
Published: June 2023

AbstractIn the United States, racial segregation still organizes the social lives of most people. This segregation of social life continues reinforcing attitudes and behaviors that sustain racial injustice in the United States. Given the longstanding structural forces sustaining the segregated status quo, why do certain individuals seek out opportunities for ‘intentional integration’? And what happens when they do? This qualitative study interviewed racially diverse participants in a community‐developed, sustained, and strategic intergroup dialogue program called Touchy Topics Tuesday (TTT), located in St. Louis, Missouri. Overall, participants (N = 30) described three interwoven motivations for involvement in the program–a catalytic moment, a long‐term commitment mindset, and/or the influence of their social network. Of all these, participants' social network was the predominant motivating force for individuals across racial lines. Participants also reported three main categories of outcomes: intellectual growth, emotional growth, and relational growth. Each of these categories encompass both attitudinal and behavioral changes. The article interrogates these major findings in the context of the intergroup dialogue literature and studies of attitude change and psychotherapy.
Risk Profile of Patients with Spontaneous Cervical Artery Dissection
Authors: Del Zotto Elisabetta , Grassi Mario , Zedde Marialuisa , Zini Andrea , Bersano Anna , Gandolfo Carlo , Silvestrelli Giorgio , Baracchini Claudio , Cerrato Paolo , Lodigiani Corrado , Marcheselli Simona , Paciaroni Maurizio , Spalloni Alessandra , Cappellari Manuel , Del Sette Massimo , Cavallini Anna , Lotti Enrico Maria , Delodovici Maria Luisa , Gentile Mauro , Magoni Mauro , Padroni Marina , Azzini Cristiano , Calloni Maria Vittoria , Giorli Elisa , Braga Massimiliano , La Spina Paolo , Melis Fabio , Tassi Rossana , Terruso Valeria , Calabrò Rocco Salvatore , Piras Valeria , Giossi Alessia , Sanguigni Sandro , Zanferrari Carla , Mannino Marina , Colombo Irene , Dallocchio Carlo , Nencini Patrizia , Bignamini Valeria , Adami Alessandro , Bella Rita , Pascarella Rosario , Keser Zafer , Pezzini Alessandro ,   the Italian Project on Stroke in Young Adults—Cervical Artery Dissection, (IPSYS CeAD) Research Group
Published: June 2023

ObjectiveEpidemiological data to characterize the individual risk profile of patients with spontaneous cervical artery dissection (sCeAD) are rather inconsistent.Methods and ResultsIn the setting of the Italian Project on Stroke in Young Adults Cervical Artery Dissection (IPSYS CeAD), we compared the characteristics of 1,468 patients with sCeAD (mean age = 47.3 ± 11.3 years, men = 56.7%) prospectively recruited at 39 Italian centers with those of 2 control groups, composed of (1) patients whose ischemic stroke was caused by mechanisms other than dissection (non‐CeAD IS) selected from the prospective IPSYS registry and Brescia Stroke Registry and (2) stroke‐free individuals selected from the staff members of participating hospitals, matched 1:1:1 by sex, age, and race. Compared to stroke‐free subjects, patients with sCeAD were more likely to be hypertensive (odds ratio [OR] = 1.65, 95% confidence interval [CI] = 1.37–1.98), to have personal history of migraine with aura (OR = 2.45, 95% CI = 1.74–3.34), without aura (OR = 2.67, 95% CI = 2.15–3.32), and family history of vascular disease in first‐degree relatives (OR = 1.69, 95% CI = 1.39–2.05), and less likely to be diabetic (OR = 0.65, 95% CI = 0.47–0.91), hypercholesterolemic (OR = 0.75, 95% CI = 0.62–0.91), and obese (OR = 0.41, 95% CI = 0.31–0.54). Migraine without aura was also associated with sCeAD (OR = 1.81, 95% CI = 1.47–2.22) in comparison with patients with non‐CeAD IS. In the subgroup of patients with migraine, patients with sCeAD had higher frequency of migraine attacks and were less likely to take anti‐migraine preventive medications, especially beta‐blockers, compared with the other groups.InterpretationThe risk of sCeAD is influenced by migraine, especially migraine without aura, more than by other factors, increases with increasing frequency of attacks, and seems to be reduced by migraine preventive medications, namely beta‐blockers. ANN NEUROL 2023;94:585–595
Asymmetric Hydrative Aldol Reaction (HAR) via Vinyl‐Gold Promoted Intermolecular Ynamide Addition to Aldehydes
Authors: Yuan Teng , Radefeld Kelton , Shan Chuan , Wegner Carter , Nichols Erin , Ye Xiaohan , Tang Qi , Wojtas Lukasz , Shi Xiaodong 
Published: June 2023

AbstractHerein, we reported an intermolecular asymmetric hydrative aldol reaction through vinyl‐gold intermediate under ambient conditions. This tandem alkyne hydration and sequential nucleophilic addition afforded a “base‐free” approach to β‐hydroxy amides with high efficiency (up to 95 % yields, >50 examples). Vinyl gold intermediate was applied as reactive nucleophile and Fe(acac)3 was used as the critical co‐catalyst to prevent undesired protodeauration, allowing this transformation to proceed under mild conditions with good functional group tolerance and excellent stereoselectivity (>20 : 1 d.r. and up to 99 % ee).
Facile Processing of Unsubstituted π‐Conjugated Aromatic Polymers through Water‐solubilization Using Aromatic Micelles
Authors: Aoyama Shinji , Catti Lorenzo , Yoshizawa Michito 
Published: June 2023

Abstractπ‐Conjugated aromatic polymers (πCAPs) are central components of functional materials yet suffer from insolubility without multiple covalent substituents on their backbones. We herein disclose a new strategy for the facile processing of unsubstituted heterocyclic πCAPs (i.e., poly(para‐phenylene‐2,6‐benzobisoxazole) and poly(benzimidazobenzo‐phenanthroline)), independent of the polymer length, via non‐covalent encircling with aromatic micelles, composed of bent aromatic amphiphiles, in water. The UV/Visible studies reveal that the efficiencies of the present encircling method are ≈10 to 50‐fold higher than those using conventional amphiphiles under the same conditions. The AFM and SEM analyses of the resultant aqueous polymer composites show that otherwise insoluble πCAPs form fine bundles (e.g., ≈1 nm in thickness) in the tubular aromatic micelles, through efficient π‐stacking interactions. In the same way, pristine poly(para‐phenylene) can be dissolved in water, displaying enhanced fluorescence (10‐fold), relative to the polymer solid. Two types of unsubstituted πCAPs are likewise co‐encircled in water, indicated by UV/Visible analysis. Importantly, aqueous processing of the encircled πCAPs into free‐standing single‐ or multicomponent films with submicrometer thickness is demonstrated through a simple filtration‐annealing protocol.
A multilevel investigation of sensory sensitivity and responsivity in autistic adults
Authors: Sapey‐Triomphe Laurie‐Anne , Dierckx Joke , Vettori Sofie , van Overwalle Jaana , Wagemans Johan 
Published: June 2023

AbstractAtypical sensory processing is a core symptom of autism spectrum disorders (ASD). We aimed at better characterizing visual sensitivity and responsivity in ASD at the self‐reported, behavioral and neural levels, and at describing the relationships between these levels. We refer to sensory sensitivity as the ability to detect sensory stimuli and to sensory responsivity as an affective response to sensory stimuli. Participants were 25 neurotypical and 24 autistic adults. At the self‐reported level, autistic participants had higher scores of sensory sensitivity and responsivity than neurotypicals. The behavioral and neural tasks involved contrast‐reversing gratings which became progressively (in)visible as their contrast or spatial frequency evolved. At the behavioral level, autistic participants had higher detection and responsivity thresholds when gratings varied in spatial frequency, but their thresholds did not differ from neurotypicals when gratings varied in contrast. At the neural level, we used fast periodic visual stimulations and electroencephalography to implicitly assess detection thresholds for contrast and spatial frequency, and did not reveal any group difference. Higher self‐reported responsivity was associated with higher behavioral responsivity, more intolerance of uncertainty and anxiety, in particular in ASD. At the self‐reported level, higher sensitivity was associated with more responsivity in both groups, contrary to the behavioral level where these relationships were not found. These heterogeneous results suggest that sensitivity and responsivity per se are not simply increased in ASD, but may be modulated by other factors such as environmental predictability. Multi‐level approaches can shed light on the mechanisms underlying sensory issues in ASD.
Einfluss von Querzugspannungen auf die Druckfestigkeit von Carbonbeton
Authors: Betz Peter , Marx Steffen , Curbach Manfred 
Published: June 2023

AbstractErste Erkenntnisse zum Tragverhalten von Carbonbetonbauteilen unter einaxialer Druckbeanspruchung liegen bereits vor, für eine Anwendung in der Baupraxis sind jedoch vor allem mehraxiale Spannungszustände von großer Relevanz. Aus dem Stahlbetonbau ist bekannt, dass Querzugspannungen zu einer reduzierten Druckfestigkeit führen, wobei international noch keine Einigkeit über die tatsächliche Höhe der Abminderung besteht. In diesem Beitrag wird untersucht, unter welchen Randbedingungen Carbonbetonscheiben unter kombinierter Druck‐Zug‐Beanspruchung geprüft werden können. Dazu gehören die versuchstechnisch erforderliche Verankerung der Carbongarne bei begrenzten Platzverhältnissen sowie der Einfluss des Belastungsregimes – proportional oder sequentiell – und des Herstellungsverfahrens – laminiert oder gegossen – auf die Versuchsergebnisse. Abschließend wird ein Ausblick auf nachfolgend geplante Untersuchungen gegeben.
Enhanced production of difficult‐to‐express proteins through knocking down rnpA gene expression
Authors: Chung Hannah , Kim Jiyong , Lee Yong Jae , Choi Kyeong Rok , Jeong Ki Jun , Kim Geun‐Joong , Lee Sang Yup 
Published: June 2023

AbstractEscherichia coli has been employed as a workhorse for the efficient production of recombinant proteins. However, some proteins were found to be difficult to produce in E. coli. The stability of mRNA has been considered as one of the important factors affecting recombinant protein production. Here we report a generally applicable and simple strategy for enhancing mRNA stability, and consequently improving recombinant protein production in E. coli. RNase P, a ribozyme comprising an RNA subunit (RnpB) and a protein subunit (RnpA), is involved in tRNA maturation. Based on the finding that purified RnpA can digest rRNA and mRNA in vitro, it was reasoned that knocking down the level of RnpA might enhance recombinant protein production. For this, the synthetic small regulatory RNA‐based knockdown system was applied to reduce the expression level of RnpA. The developed RnpA knockdown system allowed successful overexpression of 23 different recombinant proteins of various origins and sizes, including Cas9 protein, antibody fragment, and spider silk protein. Notably, a 284.9‐kDa ultra‐high molecular weight, highly repetitive glycine‐rich spider silk protein, which is one of the most difficult proteins to produce, could be produced to 1.38 g L−1, about two‐fold higher than the highest value previously achieved, by a fed‐batch culture of recombinant E. coli strain employing the RnpA knockdown system. The RnpA‐knockdown strategy reported here will be generally useful for the production of recombinant proteins including those that have been difficult to produce.
Morphometric assessment of the hip joint in children aged 2–13 years
Authors: Önal Vildan , Metin Tellioğlu Ayfer , Durum Polat Yasemin 
Published: June 2023

AbstractOur study aimed to evaluate the hip joints of healthy children aged 2–13 years morphometrically through radiographic images. Demographic characteristics of 300 healthy children in our study include an average age of 6.4 years old based on the 2‐to‐13‐year‐old bracket and sex classified to 133 girls and 167 boys. A total of 600 normal hips from these children were digitally measured based on Acetabular Index, ACM angle, MZ distance, Sharp angle, CE angle, Femoral Head Coverage Ratio, Cranial, and medial joint space (MJS). *p < 0.05; **p < 0.01 indicated a statistically significant difference. It was found that Acetabular Index, ACM angle, MZ distance, Sharp angle, Cranial, and MJSs decreased with age; Acetabular Depth value and CE angle increased with age; the CE angle differed between the sides (right–left) in the young teens period and in boys; and the cranial joint space (CJS) differed between the sides in girls. In addition, girls had higher values than boys in terms of Acetabular Index, ACM angle, Sharp angle, MZ distance, and Femoral Head Coverage Ratio; CE angle and MJS were higher in girls; and Acetabular Depth Value and CJS did not differ significantly between sexes. Obtaining the normal values will guide in the diagnosis and treatment of many clinical conditions including DDH and Legg‐Calve‐Perthes disease. It can also be used to compare the hips between healthy children and those diagnosed with Cerebral Palsy.
Prognostic impact of tumor spread through air spaces for T2aN0 stage IB non‐small cell lung cancer
Authors: Chen Zixuan , Wu Xianqiao , Fang Tianzheng , Ge Zhen , Liu Jiayuan , Wu Qinglong , Zhou Lin , Shen Jianfei , Zhou Chengwei 
Published: June 2023

AbstractBackgroundSpread through air spaces (STAS) is a pattern of invasion recently identified in non‐small cell lung cancer (NSCLC), with a poor prognosis. However, the predictive impact of STAS in stage IB NSCLC is not well understood. This investigation aims to assess the prognostic influence of STAS in stage IB NSCLC.MethodsWe reviewed 130 resected stage IB NSCLC between 2010 and 2015. Beyond the central tumor edge, lung parenchymal air gaps containing cancer cells were identified as STAS. In order to estimate recurrence‐free survival (RFS) and overall survival (OS), Cox models and Kaplan–Meier techniques were utilized. Logistic regression analysis was employed to define the factors influencing STAS.ResultsOf 130 patients, 72 (55.4%) had STAS. STAS was a significant prognosticator. Kaplan–Meier method showed that STAS‐positive patients had a significantly lower OS and RFS than STAS‐negative patients (5‐year OS, 66.5% vs. 90.4%, p = 0.02; 5‐year RFS, 59.5% vs. 89.7%, p = 0.004) In a semiquantitative assessment, the RFS and OS were shorter in survival analysis when STAS increased (5‐year RFS, 89.7%, no STAS, 61.8%, low STAS, 57.2%, high STAS, p = 0.013; 5‐year OS, 90.4%, no STAS, 78.3%, low STAS, 57.2%, high STAS, p = 0.002). The association between STAS and poor differentiation, adenocarcinoma, and vascular invasion (p value was <0.001, 0.047, and 0.041, respectively) was statistically significant.ConclusionsThe STAS is an aggressive pathological feature. RFS and OS could be significantly reduced by STAS, while it also serves as an independent predictor.
Reformulation letters in cognitive analytic therapy: The practitioner's experience
Authors: Slettevold Erlend , Fisher Paul , Leddy Adrian 
Published: June 2023

AbstractObjectivesThe aim of this study was to explore (1) cognitive analytic therapy (CAT) practitioners' experiences of receiving their own reformulation letter as part of their training and (2) CAT practitioners' perceptions about how receiving their own reformulation letter altered their clinical practice.DesignSemistructured interviews were used to elicit participants' (N = 9) experiences of having received their personal CAT, with a particular focus on the reformulation letter, and their perceptions of its impact on them as clinicians and their clinical practice.MethodsInductive “bottom up” thematic analysis was used to analyse the interview transcripts and extract overarching themes and subthemes across all participants.ResultsFour overarching themes emerged from the data: the power of the reformulation letter; inhabiting the client's role; absorbing thinking as a CAT practitioner; and evolving the therapist's technique.ConclusionsCognitive analytic therapy practitioners report experiences of the reformulation letter that indicate a positive impact on their self‐awareness, learning about CAT and consciousness about how their own clients experience therapy. This was also the case when the reformulation letter did not resonate with them to the desired extent as learning from their therapist's limitations was experienced as having an impact on their learning and subsequent practice.
Numerical study of the mixing characteristics in an air swirling fluidized bed with monodisperse and multi‐sized particles
Authors: Zhang Honghong , Liu Xuedong , Zhang Dawei , Chen Cheng , Liu Hongmei , Zheng Weiwen , Lv Kaixin , Chen Hui 
Published: June 2023

AbstractPowder mixers are used in many industries. In the present work, a new type of air swirling mixer was designed and optimized with eight horizontally arranged inlet pipes at the tangential inlet angle of 35°. The mixing of multi‐sized spherical particles (2.0, 3.0, 4.0, and 5.0 mm) was numerically investigated in the air swirling mixer by coupled computational fluid dynamics–discrete element method. The numerical results showed that multi‐sized particles achieved comparable mixing performance to monodisperse particles. The Lacey index for multi‐sized particles increased initially, and then reached a maximum value at 0.824. The upward velocity of the particles, , increased initially, and then decreased to zero along the bed height. The maximum value of occurred at a height of 40 mm. Particle radial velocity was larger near the wall than at the mixer tube centre area. The smallest particles aggregated in three layers. The collision number of the particles reached a maximum at bed height of 120 mm, which was consistent with the position of the maximum stress of the particles against the tube wall.