bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characterizing faculty motivation to implement three-dimensional learning
Authors: Nelson Paul C. , Matz Rebecca L. , Bain Kinsey , Fata-Hartley Cori L. , Cooper Melanie M. 
Published: August 2023

AbstractThe National Research Council’s Framework for K-12 Science Education and the subsequent Next Generation Science Standards have provided a widespread common language for science education reform over the last decade. These efforts have naturally been targeted at the K-12 levels, but we have argued that the three dimensions outlined in these documents—scientific practices, disciplinary core ideas, and crosscutting concepts (together termed three-dimensional learning)—are also a productive route for reform in college-level science courses. However, how and why college-level faculty might be motivated to incorporate three-dimensional learning into their courses is not well understood. Here, we report a mixed-methods study of participants in an interdisciplinary professional development program designed to support faculty in developing assessments and instruction aligned with three-dimensional learning. One cohort of faculty (N = 8) was interviewed, and four cohorts of faculty (N = 33) were surveyed. Using expectancy-value theory as an organizational framework, we identified themes of perceived values and costs that participants discussed in implementing three-dimensional learning. Based on a cluster analysis of all survey participants’ motivational profiles, we propose that these themes apply to the broader population of participants in this program. We recommend specific interventions to improve faculty motivation for implementing three-dimensional learning: emphasizing the utility value of three-dimensional learning in effecting positive learning gains for students; drawing connections between the dimensions of three-dimensional learning and faculty’s disciplinary identities; highlighting scientific practices as a key leverage point for faculty ability beliefs; minimizing cognitive dissonance for faculty in understanding the similarities and differences between the three dimensions; focusing on assessment writing as a keystone professional development activity; and aligning local evaluation practices and promotion policies with the 3DL framework.
Takotsubo cardiomyopathy prevalence and associated factors in patients presenting with a clinical picture of acute myocardial infarction in Palestine
Authors: Mtour Sameer , Abu-Hilal Lila H. , Barghouthi Duha I. , Njoum Yumna , Jabbarin Farah , Adwan Bilal , Abu Asbeh Ibrahim , Mtour Ali , Alsallamin Isaac 
Published: August 2023

Abstract
Background
Takotsubo cardiomyopathy (TC) is a transient cardiac syndrome that manifests with symptoms resembling acute myocardial infarction (MI). It is characterized by temporary wall-motion abnormalities predominantly affecting the apical and mid-portions of the left ventricle, despite the absence of significant obstructive coronary disease. TC poses diagnostic challenges due to its resemblance to ST-segment elevation myocardial infarction.
Our study aimed to determine the prevalence of TC and identify the factors associated with its occurrence in patients presenting with acute MI in Palestine.

Results
A retrospective analysis was conducted on a cohort of patients diagnosed with TC at Al-Makassed hospital. Women accounted for 90.7% of TC cases (95% CI 88.2–93.2%). The mean age of affected individuals ranged from 62 to 76 years. The most common presenting symptoms were chest pain (83.4%, 95% CI 80.0–86.7%) and dyspnea (20.4%, 95% CI 16.3–24.5%), often following an emotionally or physically stressful event. Electrocardiography (ECG) on admission indicated ST-segment elevations in 71.1% of cases (95% CI 67.2–75.1%), accompanied by mild elevations of Troponins in 85.0% of cases (95% CI 80.8–89.1%). Despite the initial severity, left ventricular ejection fraction (LVEF) improved from 20–49.9 to 59–76% within a mean time of 7–37 days. The in-hospital mortality rate was 1.7% (95% CI 0.5–2.8%), with complete recovery observed in 95.9% of cases (95% CI 93.8–98.1%) and rare recurrence. The underlying etiology is believed to involve exaggerated sympathetic stimulation.

Conclusions
TC should be considered as a significant differential diagnosis in acute coronary syndrome (ACS) cases, particularly among postmenopausal women with a preceding stressful event. Our study provides insights into the prevalence and characteristics of TC in the Palestinian population. While stress has been recognized as a potential trigger for TC, further research is needed to explore if there are specific associations between occupation and other unique stressors in the Palestinian context and the prevalence of TC. The study’s results can raise awareness among healthcare professionals in Palestine about the prevalence and characteristics of TC in their patient population.
Excessive fear of clusters of holes, its interaction with stressful life events and the association with anxiety and depressive symptoms: large epidemiological study of young people in Hong Kong
Authors: Wong Stephanie M. Y. , Tang Eric Y. H. , Hui Christy L. M. , Suen Y. N. , Chan Sherry K. W. , Lee Edwin H. M. , Chan K. T. , Wong Michael T. H. , Wilkins Arnold J. , Chen Eric Y. H. 
Published: August 2023

Background
Excessive and persistent fear of clusters of holes, also known as trypophobia, has been suggested to reflect cortical hyperexcitability and may be associated with mental health risks. No study, however, has yet examined these associations in representative epidemiological samples.

Aims
To examine the prevalence of trypophobia in a population-representative youth sample, its association with mental health and functioning, and its interaction with external stress.

Method
A total of 2065 young people were consecutively recruited from a household-based epidemiological youth mental health study in Hong Kong. Trypophobia, symptoms of anxiety, depression and stress, and exposure to personal stressors were assessed. Logistic regression was used to assess the relationships between trypophobia and mental health. Potential additive and interaction effects of trypophobia and high stress exposure on mental health were also tested.

Results
The prevalence of trypophobia was 17.6%. Trypophobia was significantly associated with severe symptoms of anxiety (odds ratio (OR) = 1.83, 95% CI = 1.32–2.53), depression (OR = 1.78, 95% CI = 1.24–2.56) and stress (OR = 1.68, 95% CI = 1.11–2.53), even when accounting for sociodemographic factors, personal and family psychiatric history, resilience and stress exposure. Dose–response relationships were observed, and trypophobia significantly potentiated the effects of stress exposure on symptom outcomes, particularly for depressive symptoms. Those with trypophobia also showed significantly poorer functioning across domains and poorer health-related quality of life.

Conclusions
Screening for trypophobia in young people may facilitate early risk detection and intervention, particularly among those with recent stress exposure. Nevertheless, the generally small effect sizes suggest that other factors have more prominent roles in determining recent mental health outcomes in population-based samples; these should be explored in future work.
Dose-tapering trajectories in patients with remitted psychosis undergoing guided antipsychotic reduction to reach minimum effective dose
Authors: Liu Chen-Chung , Hsieh Ming H. , Chien Yi-Ling , Liu Chih-Min , Lin Yi-Ting , Hwang Tzung-Jeng , Hwu Hai-Gwo 
Published: August 2023

Abstract

Background
Patients with remitted psychosis wish to reduce antipsychotic doses yet facing increased risks of relapse. Examining dose-tapering processes may provide insights to re-evaluate the risk-to-benefit balance. We aimed to depict and subgroup tapering trajectories, and explore factors associated with different dose-reduction patterns.

Methods
A 2-year open-label randomized prospective comparative trial from August 2017 to September 2022 in Taiwan. Patients with a history of schizophrenia-related psychotic disorders under stable medications and symptoms were eligible, randomizing a proportion to conduct guided dose reduction. We depicted the trajectories of individual patients and named subgroups based on dose-tapering patterns. Predictors of baseline characteristics for designated subgroups were examined by logistic regression analysis; changes in outcomes were compared by paired t-test.

Results
Fifty-one patients undergoing guided dose reduction, 18 (35.3%) reduced 4 steps consecutively (sequential reducers, SR), 14 (27.5%) reduced 1 to 3 steps (modest reducers, MR), 3 (5.9%) re-escalated to previous level (alert reducers, AR), 7 (13.7%) returned to baseline level (baseline returners, BR), 6 (11.7%) relapsed (failed reducers, FR) and 3 (5.9%) withdrew without relapse (early exits, EE). Patients with a history of relapse assumed a conservative dose-tapering pace; only the SR subgroup exhibited significant improvements in functioning and quality of life while failing to identify variables for predicting who would become SR or FR.

Conclusions
Guided dose reduction comprises dynamic processes with differences between individual trajectories. The proposed naming of dose-tapering patterns/subgroups provides a framework depicting patients undergoing dose-tapering. Longer-term observation and more flexible tapering approaches are anticipated to reveal favorable outcomes.
Physical health disparities and severe mental illness: A longitudinal comparative cohort study using hospital data in Northern Ireland
Authors: McCarter Rachel , Rosato Michael , Thampi Annette , Barr Ruth , Leavey Gerard 
Published: August 2023

Abstract

Background
People with severe mental illness (SMI) die prematurely, mostly due to preventable causes.

Objective
To examine multimorbidity and mortality in people living with SMI using linked administrative datasets.

Method
Analysis of linked electronically captured routine hospital administrative data from Northern Ireland (2010–2021). We derived sex-specific age-standardised rates for seven chronic life-limiting physical conditions (chronic kidney disease, malignant neoplasms, diabetes mellitus, chronic obstructive pulmonary disease, chronic heart failure, myocardial infarction, and stroke) and used logistic regression to examine the relationship between SMI, socio-demographic indicators, and comorbid conditions; survival models quantified the relationship between all-cause mortality and SMI.

Results
Analysis was based on 929,412 hospital patients aged 20 years and above, of whom 10,965 (1.3%) recorded a diagnosis of SMI. Higher likelihoods of an SMI diagnosis were associated with living in socially deprived circumstances, urbanicity. SMI patients were more likely to have more comorbid physical conditions than non-SMI patients, and younger at referral to hospital for each condition, than non-SMI patients. Finally, in fully adjusted models, SMI patients had a twofold excess all-cause mortality.

Conclusion
Multiple morbidities associated with SMI can drive excess mortality. While SMI patients are younger at referral to treatment for these life-limiting conditions, their relatively premature death suggests that these conditions are also quite advanced. There is a need for a more aggressive approach to improving the physical health of this population.
Small Indels in the Androgen Receptor Gene: Phenotype Implications and Mechanisms of Mutagenesis
Authors: Ramos Raquel Martinez , Petroli Reginaldo José , D’Alessandre Nathália Da Roz , Guardia Gabriela Der Agopian , Afonso Ana Caroline de Freitas , Nishi Mirian Yumie , Domenice Sorahia , Galante Pedro Alexandre Favoretto , Mendonca Berenice Bilharinho , Batista Rafael Loch 
Published: August 2023

Abstract

Context
Despite high abundance of small indels in human genomes, their precise roles and underlying mechanisms of mutagenesis in Mendelian disorders require further investigation.

Objective
To profile the distribution, functional implications, and mechanisms of small indels in the androgen receptor (AR) gene in individuals with androgen insensitivity syndrome (AIS).

Methods
We conducted a systematic review of previously reported indels within the coding region of the AR gene, including 3 novel indels. Distribution throughout the AR coding region was examined and compared with genomic population data. Additionally, we assessed their impact on the AIS phenotype and investigated potential mechanisms driving their occurrence.

Results
A total of 82 indels in AIS were included. Notably, all frameshift indels exhibited complete AIS. The distribution of indels across the AR gene showed a predominance in the N-terminal domain, most leading to frameshift mutations. Small deletions accounted for 59.7%. Most indels occurred in nonrepetitive sequences, with 15.8% situated within triplet regions. Gene burden analysis demonstrated significant enrichment of frameshift indels in AIS compared with controls (P &lt; .00001), and deletions were overrepresented in AIS (P &lt; .00001).

Conclusion
Our findings underscore a robust genotype-phenotype relationship regarding small indels in the AR gene in AIS, with a vast majority presenting complete AIS. Triplet regions and homopolymeric runs emerged as prone loci for small indels within the AR. Most were frameshift indels, with polymerase slippage potentially explaining half of AR indel occurrences. Complex frameshift indels exhibited association with palindromic runs. These discoveries advance understanding of the genetic basis of AIS and shed light on potential mechanisms underlying pathogenic small indel events.
Insulin Resistance Is Associated With Reduced Capillary Permeability of Thigh Muscles in Patients With Type 2 Diabetes
Authors: Mooshage Christoph M , Tsilingiris Dimitrios , Schimpfle Lukas , Kender Zoltan , Aziz-Safaie Taraneh , Hohmann Anja , Szendroedi Julia , Nawroth Peter , Sturm Volker , Heiland Sabine , Bendszus Martin , Kopf Stefan , Kurz Felix T , Jende Johann M E 
Published: August 2023

Abstract

Context
Insulin-mediated microvascular permeability and blood flow of skeletal muscle appears to be altered in the condition of insulin resistance. Previous studies on this effect used invasive procedures in humans or animals.

Objective
The aim of this study was to demonstrate the feasibility of a noninvasive assessment of human muscle microcirculation via dynamic contrast-enhanced (DCE)-magnetic resonance imaging (MRI) of skeletal muscle in patients with type 2 diabetes (T2D).

Methods
A total of 56 participants (46 with T2D, 10 healthy controls [HC]) underwent DCE-MRI of the right thigh at 3 Tesla. The constant of the musculature's microvascular permeability (Ktrans), extravascular extracellular volume fraction (ve), and plasma volume fraction (vp) were calculated.

Results
In T2D patients, skeletal muscle Ktrans was lower (HC 0.0677 ± 0.002 min−1, T2D 0.0664 ± 0.002 min−1; P = 0.042) while the homeostasis model assessment (HOMA) index was higher in patients with T2D compared to HC (HC 2.72 ± 2.2, T2D 6.11 ± 6.2; P = .011). In T2D, Ktrans correlated negatively with insulin (r = −0.39, P = .018) and HOMA index (r = −0.38, P = .020).

Conclusion
The results signify that skeletal muscle DCE-MRI can be employed as a noninvasive technique for the assessment of muscle microcirculation in T2D. Our findings suggest that microvascular permeability of skeletal muscle is lowered in patients with T2D and that a decrease in microvascular permeability is associated with insulin resistance. These results are of interest with regard to the impact of muscle perfusion on diabetic complications such as diabetic sarcopenia.
Impressive clinical response following combined BRAF and MEK inhibition in a low-grade serous ovarian carcinoma patient with a BRAF V600E mutation
Authors: Rodzajewska Anna , Kuryło Weronika , Szklener Katarzyna 
Published: August 2023

Introduction: Low-grade serous ovarian cancer (LGSOC) accounting for less than 10% of all serous ovary cancers. The chemoresistance inherent to this type of ovarian cancer narrows the therapeutic options, especially in the recurrent setting. It is thought that the mitogen-activated protein kinase (MAPK) pathway plays a significant role in the pathogenesis of these tumours, and about 2 to 20% of LGSOC harbour a BRAF mutation.
Case report: We present a case report of a 58-year-old woman with LGSOC FIGO stage IIIC who presented recurrence of the tumor process after total abdominal hysterectomy and systemic treatment. Thereafter, she underwent molecular profiling, which revealed a BRAF V600E mutation; accordingly, the patient was administered dabrafenib and trametinib combination therapy. The patient noted significant clinical improvement with normalization of CA 125 and radiological partial response. To date, the patient still maintains partial response, with good treatment tolerance and performance status ECOG 0/1 and good quality of life.
Conclusions: LGSOC represents the challenge that is managing a rare cancer with scarce therapeutic options. Given the prevalence of BRAF mutations in this type of tumour, it might be relevant to consider genetic testing. It may provide new treatment opportunities for patients with a known chemoresistant tumour, by identifying potential actionable targets and avoid potential toxicities associated with chemotherapy. Here we demonstrate that impressive clinical responses can be achieved in BRAF mutated LGSOC treated with combined BRAF and MEK inhibitor treatment.
Pressure injury incidence and impact on patients treated with prone positioning for COVID-19 ARDS
Authors: Nadeem Rashid , Chirayath-Wilson Nivea , D'souza Jeeshal Priya , Dsouza Flora Sheetal , Thomas Blessy Prince , Mathew Manoj , Sharma Ekta , Zahra Ahmed Najah , Ignacio Reychelle Ann Sumcio , Cherian Minu Shibu , Basheer Irshad , Kokash Feras , Memon Marvi , Tariq Rana 
Published: August 2023

Objective:To determine the incidence of pressure injuries (PIs) and their impact on clinical outcomes in patients treated with prone positioning for COVID-19 acute respiratory distress syndrome (ARDS).Method:All patients with COVID-19 ARDS who were treated with prone positioning were categorised as cases and those who were not treated with prone positioning were categorised as controls. Demographics, clinical data and confounding variables affecting outcomes were recorded. Outcome variables of mortality and length of stay in intensive care units (ICUs) for both groups were recorded. Both groups' incidence of PIs were recorded and compared using statistical tests. Fisher's exact test was used for categorical variables, and Mann–Whitney U test was used for continuous variables.Results:The sample included 212 patients, treated with prone position (n=104) and without prone treatment (n=108). The incidence of PIs was n=75 (35.4%). PIs were significantly higher in patients in the prone position (n=51, 49%) compared with patients who were not (n=24, 22%); p=0.001. Patients in the prone position were found to have lower APACHE-2 scores, longer stays on the ventilator, ICU and in the hospital.Conclusion:PIs are more prevalent in patients in the prone position and it adversely impacts clinical outcomes; it prolongs the length of stay on the ventilator, in the ICU and in the hospital.
Responsible Chemistry
Authors: Mehlich Jan 
Published: August 2023

Abstract
Responsible Research and Innovation (RRI) is a concept that describes approaches and strategies to addressing and tackling risks and dual use potentials of research and development (R&D) activities that have significant societal and environmental impact [1]. Built on a scientifically rigorous foundation of RRI knowledge and expertise, the translation into applied and practical contexts such as chemical R&D is underway [2]. Here, a framework for integrating environmental and ecological ethics dimensions into chemists’ scientific integrity and good scientific practice guidelines is suggested under the umbrella of RRI.
Location of faults based on deep learning with feature selection for meter placement in distribution power grids
Authors: Degano Iván L. , Fiaschetti Leandro , Lotito Pablo A. 
Published: August 2023

Abstract
A problem of great interest for power distribution companies is ensuring uninterrupted service in extensive power distribution systems. Thus, the monitoring of networks and identification of system faults become essential. This work focuses on identifying a fault’s occurrence from a small number of low-cost measurements in a power distribution system. The determination of sensor locations is based on the recent feature selection approach LassoNet, where the measurement locations are ranked. It provides the most informative measures during a fault resulting in a shortening data set. It is used as input to a deep neural network without a significant loss in accuracy. We validate our method on the IEEE 13 and 34 node test feeders for distribution systems to conduct the suggested approach’s experimental studies.
Comparative analysis of fuel burnup calculations of fourth-generation European fast reactors
Authors: Ibrahim Amr 
Published: August 2023

Abstract
The sustainability of nuclear energy implies the continuous research and development of fast reactor technology. This work represents a comparative analysis of fuel burnup calculations of three commercial-level fast spectrum concepts which are under research and development in Europe. The investigated designs are the European Sodium-cooled Fast Reactor, the European Lead-cooled Fast Reactor, and the European Gas-cooled Fast Reactor. MCNPX transport code was used to design three representative fuel assemblies of these fourth-generation concepts to analyze and compare their neutronic and safety parameters. The neutronic and safety analysis in this work includes the evolution of infinite multiplication factor and fissile inventory, neutron yield, the average energy of neutrons causing fission, neutron energy spectrum, neutron generation time, Doppler reactivity effect, effective delayed neutron fraction, and coolant void reactivity coefficient. The fuel burnup results showed that the ESFR is superior regarding the reactivity swing and breeding of fissile 239Pu. On the other hand, analysis of safety parameters results showed that they depend mainly on fuel composition rather than on other design specifications.
Round bar notch shape optimization for tensile stress concentration testing
Authors: Ozsoy Murat , Akşen Toros Arda , Ekşi Seçil , Ozsoy Neslihan , Firat Mehmet 
Published: August 2023

Abstract
Notched structures in machine parts for several reasons cause discontinuity and stress concentration. It is essential to optimize these stress concentrations in notched parts. This study determined the best notch shape by creating different notch shapes by keeping two key points fixed on the spline curve in the notched region. This paper involves optimizing the shape of a fillet in a notched tension bar. An optimal shape was aimed to minimize the notch factor without causing yield anywhere in the bar by parametrically controlling the spline of the fillet via ANSYS parametric design language code. Optimal shapes of B-spline curves were obtained for round bars subject to axial tension loadings. Changing the code can also be used for bending or combined loading conditions other than tensile loading.