bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tetracycline resistance potential of heterotrophic bacteria isolated from freshwater fin-fish aquaculture system
Authors: Kusunur Ahamed Basha , Mogilipuri Shanmukha Sai , Moturu Dhamodher , Benala Manikantha , Vaiyapuri Murugadas , Panda Satyen Kumar , George Joshy Chalil , Badireddy Madhusudana Rao 
Published: March 2023

AbstractAimsThis study investigated the tetracycline resistance potential of heterotrophic bacteria isolated from twenty-four freshwater fin-fish culture ponds in Andhra Pradesh, India.Methods and resultsA total of 261 tetracycline resistant bacteria (tetR) were recovered from pond water, pond sediment, fish gills, fish intestine, and fish feed. Bacteria with high tetracycline resistance (tetHR) (n = 30) that were resistant to tetracycline concentrations above 128  μg mL−1 were predominantly Lactococcus garvieae followed by Enterobacter spp., Lactococcus lactis, Enterobacter hormaechei, Staphylococcus arlettae, Streptococcus lutetiensis, Staphylococcus spp., Brevundimonas faecalis, Exiguobacterium profundum, Lysinibacillus spp., Stutzerimonas stutzeri, Enterobacter cloacae, and Lactococcus taiwanensis. Resistance to 1024 μg mL−1 of tetracycline was observed in L. garvieae, S. arlettae, Enterobacter spp., B. faecalis. Tet(A) (67%) was the predominant resistance gene in tetHR followed by tet(L), tet(S), tet(K), and tet(M). At similar concentrations of exposure, tetracycline procured at the farm level (69.5% potency) exhibited lower inhibition against tetHR bacteria compared to pure tetracycline (99% potency). The tetHR bacteria showed higher cross-resistance to furazolidone (100%) followed by co-trimoxazole (47.5%) and enrofloxacin (11%).ConclusionsThe maximum threshold of tetracycline resistance at 1024 μg mL−1 was observed in S. arlettae, Enterobacter spp., B. faecalis, and L. garvieae and tet(A) was the major determinant found in this study.
Lactiplantibacillus plantarumP101 alleviated lead-induced more severe hepatic injury in obese mice, by promoting fecal lead excretion and enhancing antioxidative defense system
Authors: Hu Liehai , Zhao Yu , You Tao , Xu Hengyi 
Published: March 2023

AbstractAimsLead (Pb) is a toxic heavy metal that has been intensively studied, but its toxicity in sub-healthy people remains unclear. This study aims to investigate the adverse effects of Pb in the obese population and validate the feasibility of a potential probiotic strain for the treatment of Pb poisoning and diet-induced obesity.Methods and ResultsMale Kunming mice were fed a high-fat/high-sugar (HFHS) diet for 6 weeks, then received Pb exposure and Lactiplantibacillus plantarum P101 supplementation for 2 weeks. The histopathology of the liver and colon was observed, and biochemical indicators and gene expression levels were measured.ConclusionsHere, we reported that Pb exposure exacerbated the existing oxidative stress and gut barrier injury in obese mice, leading to more severe Pb accumulation, and hepatic inflammatory injury compared with normal diet-fed mice. It is worth noting that the P101 treatment significantly reduced Pb accumulation by promoting fecal Pb excretion and enhanced the antioxidant capacity of mice. After P101 treatment, obesity-related indicators were downregulated, and the hepatic injury and gut barrier disruption in mice were alleviated effectively.
Torula yeast may improve intestinal health and immune function of weanling pigs
Authors: Espinosa Charmaine D , Torres-Mendoza Leidy J , Stein Hans H 
Published: March 2023

AbstractAn experiment was conducted to test the hypothesis that inclusion of a conventional torula yeast or a torula yeast produced from forestry byproducts (i.e., woody torula yeast) in diets for weanling pigs instead of fish meal and plasma protein improves growth performance and intestinal health of pigs. A total of 120 weanling pigs (6.53 ± 0.78 kg) were allotted to three treatments with ten replicate pens per diet. Pigs were fed one of three diets from days 1 to 14 post-weaning (phase 1), whereas all pigs were fed a common diet in phase 2 (days 15 to 28). The three treatments in phase 1 included a control diet with 5% fish meal, 3.5% plasma protein, and no torula yeast. The second diet contained 1.5% fish meal, 14% woody torula yeast, and no plasma protein, whereas the third diet contained 1.5% fish meal, 14% conventional torula yeast, and no plasma protein. Fecal scores were assessed every other day. On day 7, one pig per pen was euthanized to collect ileal tissue and mucosa for determination of morphology and for ribonucleic acid (RNA) sequencing analysis. At the end of phases 1 and 2, blood samples were collected and concentrations of cytokines, plasma urea nitrogen (PUN), peptide YY, immunoglobulin G, total protein, and albumin were analyzed. Results indicated that both torula yeast sources could replace fish meal and plasma protein without affecting growth performance, intestinal morphology, or blood characteristics of pigs. Pigs fed a diet containing torula yeast had improved (P &lt; 0.05) fecal scores during phase 1. Pigs fed the conventional torula yeast diet had greater (P &lt; 0.05) concentration of interleukin-2 compared with pigs fed the control diet. On day 14, greater (P &lt; 0.05) concentrations of interleukin-4 and interleukin-10 were observed in pigs fed the diet containing the woody torula yeast or conventional torula yeast compared with pigs fed the control diet. Results from the RNA sequencing indicated that 19 of 24 analyzed genes involved in digestion and absorption of protein and vitamins were downregulated in pigs fed the diet containing woody torula yeast compared with pigs fed the control diet. However, only two genes (i.e., ANKS4B and FAM54A) were downregulated in pigs fed the woody torula yeast diet compared with the conventional torula yeast diet. In conclusion, using woody or conventional torula yeast instead of fish meal and plasma protein in the phase 1 diet for weanling pigs may improve intestinal health without influencing growth performance of pigs.
Consumer Desires and the Fluctuating Balance between Liquid and Solid Consumption: The Case of Finnish Clothing Libraries
Authors: Rosenberg Laura M , Weijo Henri A , Kerkelä Iina 
Published: March 2023

Abstract
The ongoing rise of liquid consumption manifests in the growing popularity of ephemeral, access-based, and dematerialized forms of consumption that contrast with traditional solid forms of consumption characterized by possession and strong object relationships. The literature already presents a robust understanding of what makes liquid and solid consumption appealing to consumers. What has received less attention is the co-existence of liquid and solid consumption in consumers’ lived experiences. Furthermore, the literature does not explain how the balance that consumers achieve between liquid and solid consumption fluctuates over time. This study illuminates the co-existence of liquid and solid consumption through a phenomenological inquiry of subscription-based clothing libraries, a context where solid personal possessions frequently mix with liquid accessed items in everyday use. Findings show that changes in consumer desire play a major role in consumer decisions to liquify or solidify consumption, especially over time. Overall, the study provides new theoretical insights into liquid and solid consumption, consumer desire, and burdens of access-based consumption.
Tracking Inattention
Authors: Goldstein Nathan 
Published: March 2023

Abstract
This study proposes a real-time estimate of inattention, based on micro-level data. I show that a simple specification that estimates the persistence of a forecaster's deviation from the mean provides a direct estimate of parameters of information frictions according to prominent models of expectations. The new estimate can also be interpreted as a hybrid measure of both information frictions and behavioral frictions. Using the new specification, I revise several key findings documented in the previous literature. I find higher levels of inattention and document new forms of variations over time and across variables, horizons, individuals, and types of agents. I also report new results from long-run forecasts and document an unprecedented response to COVID-19.
Learning torus PCA-based classification for multiscale RNA correction with application to SARS-CoV-2
Authors: Wiechers Henrik , Eltzner Benjamin , Mardia Kanti V , Huckemann Stephan F 
Published: March 2023

Abstract
Three-dimensional RNA structures frequently contain atomic clashes. Usually, corrections approximate the biophysical chemistry, which is computationally intensive and often does not correct all clashes. We propose fast, data-driven reconstructions from clash-free benchmark data with two-scale shape analysis: microscopic (suites) dihedral backbone angles, mesoscopic sugar ring centre landmarks. Our analysis relates concentrated mesoscopic scale neighbourhoods to microscopic scale clusters, correcting within-suite-backbone-to-backbone clashes exploiting angular shape and size-and-shape Fréchet means. Validation shows that learned classes highly correspond with literature clusters and reconstructions are well within physical resolution. We illustrate the power of our method using cutting-edge SARS-CoV-2 RNA.
Open questions in plant cell wall synthesis
Authors: McFarlane Heather E 
Published: March 2023

AbstractPlant cells are surrounded by strong yet flexible polysaccharide-based cell walls that support cells while also allowing growth by cell expansion. Plant cell wall research has advanced tremendously in recent years. Sequenced genomes of model and crop plants have facilitated cataloguing and characterization of many enzymes involved in cell wall synthesis. Structural information has been generated for several important cell wall-synthesizing enzymes. Important tools have been developed including antibodies raised against a variety of cell wall polysaccharides and glycoproteins, collections of enzyme clones and synthetic glycan arrays for characterizing enzymes, herbicides that specifically affect cell wall synthesis, live-cell imaging probes to track cell wall synthesis, and an inducible secondary cell wall synthesis system. Despite these advances, and often because of the new information they provide, many open questions about plant cell wall polysaccharide synthesis persist. This article highlights some of the key questions that remain open, reviews the data supporting different hypotheses that address these questions, and discusses technological developments that may answer these questions in the future.
Modulatory effect ofOriganum vulgareessential oil and carvacrol onMalasseziaspp. virulence factors
Authors: Angiolella Letizia , Rojas Florencia , Mussin Javier , Giusiano Gustavo 
Published: March 2023

AbstractMalassezia sympodialis and Malassezia furfur are recognized as an important part of the human and animals healthy skin microbiota, but also as an opportunistic fungus due to their association with a broad spectrum of skin and systemic infections. Human skin infections associated with Malassezia spp. are often chronic, recurrent, and topical or oral azole treatments are challenging with not always successful outcomes. A wide inter and intraspecies antifungal susceptibility variability that may suggest a combination of wild-type strains and resistant mutants was reported. The essential oils are complex hydrophobic mixtures of different compounds extracted from plants by distillation and have demonstrated antimicrobial activity. In this study, toxicity in the larvae model and the ability of Origanum vulgare essential oil (OVEO) and carvacrol to inhibit virulence factors such as hydrophobicity, adherence, and biofilm formation of M. sympodialis and M. furfur was evaluated. We have demonstrated the antifungal activity of OVEO and carvacrol against both species. Carvacrol was more active and less toxic than OVEO at low concentrations (&lt; 1 mg/ml). Malassezia sympodialis showed a significant decrease in adherence and its ability to form biofilms when OVEO or carvacrol is present. Both Malassezia species showed reduced hydrophobicity in the presence of carvacrol. Further studies will have to be carried out to understand how these substances act, but the inhibition of some virulence factors could represent a new target to overcome the problem of drug resistance.
Type Ia supernovae SN 2013bz, PSN J0910 + 5003, and ASASSN-16ex: similar to 09dc-like?
Authors: Tiwari S , Chakradhari N K , Sahu D K , Anupama G C , Kumar B , Sahu K R 
Published: March 2023

ABSTRACT
We present optical photometric and spectroscopic studies of three supernovae (SNe): SN 2013bz, PSN J0910 + 5003, and ASASSN-16ex (SN 2016ccj). UV–optical photometric data of ASASSN-16ex obtained with the Swift Ultraviolet/Optical Telescope (UVOT) are also analysed. These objects were initially classified as 09dc-like type Ia SNe. The decline-rate parameters (Δm15(B)true) are derived as 0.92 ± 0.04 (SN 2013bz), 0.70 ± 0.05 (PSN J0910 + 5003), and 0.73 ± 0.03 (ASASSN-16ex). The estimated B-band absolute magnitudes at maximum, −19.61 ± 0.20 mag for SN 2013bz, −19.44 ± 0.20 mag for PSN J0910 + 5003, and −19.78 ± 0.20 mag for ASASSN-16ex, indicate that all three objects are relatively bright. The peak bolometric luminosities for these objects are derived as $\log L_\text{bol}^\text{max} =$ 43.38 ± 0.07, 43.26 ± 0.07, and 43.40 ± 0.06 erg s−1, respectively. The spectral and velocity evolution of SN 2013bz is similar to that of a normal SN Ia, hence it appears to be a luminous, normal type Ia supernova. On the other hand, the light curves of PSN J0910 + 5003 and ASASSN-16ex are broad and exhibit properties similar to 09dc-like SNe Ia. Their spectroscopic evolution shows similarity with 09dc-like SNe: strong C ii lines are seen in the pre-maximum spectra of these two events. Their photospheric velocity evolution is similar to SN 2006gz. Further, in the UV bands, ASASSN-16ex is very blue, like other 09dc-like SNe Ia.
The multiwavelength view of shocks in the fastest nova V1674 Her
Authors: Sokolovsky K V , Johnson T J , Buson S , Jean P , Cheung C C , Mukai K , Chomiuk L , Aydi E , Molina B , Kawash A , Linford J D , Mioduszewski A J , Rupen M P , Sokoloski J L , Williams M N , Steinberg E , Vurm I , Metzger B D , Page K L , Orio M , Quimby R M , Shafter A W , Corbett H , Bolzoni S , DeYoung J , Menzies K , Romanov F D , Richmond M , Ulowetz J , Vanmunster T , Williamson G , Lane D J , Bartnik M , Bellaver M , Bruinsma E , Dugan E , Fedewa J , Gerhard C , Painter S , Peterson D-M , Rodriguez J E , Smith C , Sullivan H , Watson S 
Published: March 2023

ABSTRACT
Classical novae are shock-powered multiwavelength transients triggered by a thermonuclear runaway on an accreting white dwarf. V1674 Her is the fastest nova ever recorded (time to declined by two magnitudes is t2 = 1.1 d) that challenges our understanding of shock formation in novae. We investigate the physical mechanisms behind nova emission from GeV γ-rays to cm-band radio using coordinated Fermi-LAT, NuSTAR, Swift, and VLA observations supported by optical photometry. Fermi-LAT detected short-lived (18 h) 0.1–100 GeV emission from V1674 Her that appeared 6 h after the eruption began; this was at a level of (1.6 ± 0.4) × 10−6 photons cm−2 s−1. Eleven days later, simultaneous NuSTAR and Swift X-ray observations revealed optically thin thermal plasma shock-heated to kTshock = 4 keV. The lack of a detectable 6.7 keV Fe Kα emission suggests super-solar CNO abundances. The radio emission from V1674 Her was consistent with thermal emission at early times and synchrotron at late times. The radio spectrum steeply rising with frequency may be a result of either free-free absorption of synchrotron and thermal emission by unshocked outer regions of the nova shell or the Razin–Tsytovich effect attenuating synchrotron emission in dense plasma. The development of the shock inside the ejecta is unaffected by the extraordinarily rapid evolution and the intermediate polar host of this nova.
Influence of the dynamic classification of asteroids on observation astrometric errors: a statistical analysis
Authors: Stronati N , Faggioli L , Micheli M , Ceccaroni M 
Published: March 2023

ABSTRACT
The ephemerides of minor planets are computed on the basis of astrometric observations. The asteroid orbit determination process requires these observations to be properly weighted to take into account the expected accuracy of the data. If not directly provided by the observers, the weights are, in general, computed after a station-specific statistical analysis on the observation residuals, where the influence of external factors such as epoch of observation, magnitude, and employed catalogue has been proven. In this paper, we perform a statistical analysis on observation residuals of the major surveys taking into account a new factor, i.e. the dynamical classification of asteroids, to understand whether the observation quality may have a dependence on the different type of observed object. If an influence is actually found, then it will be possible to develop a new weighting system based on these results. The weights will be easily applicable once one knows the asteroid orbit. In particular, four stations have been found having different qualities depending on whether they are observing near-Earth asteroids or main-belt asteroids. Moreover, the cross-correlation between the dynamic classification and epoch, magnitude, and catalogue is investigated, as well as the influence of these factors on observations’ quality.
A search for compact object companions to high mass function single-lined spectroscopic binaries in Gaia DR3
Authors: Jayasinghe T , Rowan D M , Thompson Todd A , Kochanek C S , Stanek K Z 
Published: March 2023

ABSTRACT
Gaia Data Release 3 (DR3) provides &gt;181 000 radial velocity (RV) solutions for single-lined spectroscopic binaries (SB1s) that can be used to search for non-interacting compact object + star binary candidates by selecting systems with large mass functions. We selected 234 such systems and identified 115 systems with good RV solutions in DR3. We used light curves from the All-Sky Automated Survey for SuperNovae (ASAS-SN) and the Transiting Exoplanet Survey Satellite (TESS) to identify and remove 31 eclipsing binaries to produce a catalogue of 80 compact object + star candidates, including 38 ellipsoidal variables. The positions of these candidates on Gaia and Two Micron All-Sky Survey (2MASS) colour–magnitude diagrams (CMDs) suggest that many of these systems are binaries with luminous companions. We compared the periods and eccentricities of detached eclipsing binaries in Gaia DR3 and ASAS-SN, and found that ${\sim }11 {{\ \rm per\ cent}}$ and ${\sim }60 {{\ \rm per\ cent}}$ of the binaries had different periods and eccentricities. We also compared RV solutions for 311 binaries in both Gaia DR3 and the Ninth Catalogue of Spectroscopic Binary Orbits (SB9), and found similar results. We do not identify any strong candidates for non-interacting compact object + star binaries.
Magnetohydrodynamic simulations of the Tayler instability in rotating stellar interiors
Authors: Ji Suoqing , Fuller Jim , Lecoanet Daniel 
Published: March 2023

ABSTRACT
The Tayler instability is an important but poorly studied magnetohydrodynamic (MHD) instability that likely operates in stellar interiors. The non-linear saturation of the Tayler instability is poorly understood and has crucial consequences for dynamo action and angular momentum transport in radiative regions of stars. We perform three-dimensional MHD simulations of the Tayler instability in a cylindrical geometry, including strong buoyancy and Coriolis forces as appropriate for its operation in realistic rotating stars. The linear growth of the instability is characterized by a pre-dominantly m = 1 oscillation with growth rates roughly following analytical expectations. The non-linear saturation of the instability appears to be caused by secondary shear instabilities and is also accompanied by a morphological change in the flow. We argue, however, that non-linear saturation likely occurs via other mechanisms in real stars where the separation of scales is larger than those reached by our simulations. We also observe dynamo action via the amplification of the axisymmetric poloidal magnetic field, suggesting that Tayler instability could be important for magnetic field generation and angular momentum transport in the radiative regions of evolving stars.
Validation of Urinary Thiocyanate as a Robust Biomarker of Active Tobacco Smoking in the Prospective Urban and Rural Epidemiological Study
Authors: Mathiaparanam Stellena , Gill Biban , Sathish Thirunavukkarasu , Paré Guillaume , Teo Koon K , Yusuf Salim , Britz-McKibbin Philip 
Published: March 2023

Abstract

Introduction
Tobacco smoking is a leading preventable cause of premature death globally. Urinary thiocyanate is a biomarker of cyanide exposure from tobacco smoke; however, few studies have evaluated its utility in diverse populations of smokers.

Aims and Methods
We examined the associations between urinary thiocyanate and self-reported never and current smokers among 1000 participants from 14 countries in the Prospective Urban and Rural Epidemiological study. We analyzed urinary thiocyanate in light and heavy smokers as compared to never-smokers from high- (HICs), middle- (MICs), and low-income countries (LICs) using a validated capillary electrophoresis method in conjunction with standardized questionnaires.

Results
The median urinary thiocyanate concentration was 31 μM, which ranged from 8.6 μM to 52 μM for never-smokers (n = 335) and current smokers (n = 660), respectively. Urinary thiocyanate was correlated with daily cigarette consumption (r = 0.621) and total nicotine equivalents (r = 0.514). Thiocyanate also displayed a better dose–response than urinary cotinine. A moderate association of urinary thiocyanate was found in biochemically verified never-smokers (r ~0.38) because of intake of vegetables, fruits, and dairy. Receiver-operating characteristic curves established cutoff values for urinary thiocyanate to differentiate current from never-smokers with an optimal threshold of 23.9 μM (Area Under the Curve or AUC = 0.861), which lowered progressively from HICs, MICs, and LICs.

Conclusions
Elevated thiocyanate was evident in current smokers from high-income countries likely reflecting differences in smoking topography and greater toxicant burden. Background urinary thiocyanate in never-smokers was associated with goitrogenic food intake that obscured detection of secondhand smoke exposure.

Implications
Urinary thiocyanate is a sensitive biomarker of active tobacco smoking relative to cotinine that can be measured by an inexpensive capillary electrophoresis assay. Regional cutoff values are demonstrated to improve discrimination of smoking status in developing countries because of differences in smoking habits and cigarette products consumed, as well as intake of goitrogenic foods. Urinary thiocyanate may allow for more reliable estimates of the hazards of tobacco smoking between countries with varying socioeconomic development as compared to self-reports.
Disseminated Cryptococcosis Following Eculizumab Therapy: Insight Into Pathogenesis
Authors: Lortholary Olivier , El-Sissy Carine , Leporrier Jérémie , Sze Wah Wong Sarah , Dannaoui Eric , Fremeaux-Bacchi Véronique , Aimanianda Vishukumar 
Published: March 2023

AbstractEculizumab, a recombinant humanized monoclonal antibody (mAb), is used for the treatment of patients (both adults and children) with paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome. This mAb binds to complement protein 5 (C5), thereby inhibiting its cleavage. On the other hand, one of the C5 cleavage products, C5a, is a potent anaphylatoxin with proinflammatory properties, involved in antimicrobial surveillance. Administration of eculizumab has been reported to make patients more susceptible to infection by encapsulated bacteria. Here, we are reporting an adult case of disseminated infection due to the encapsulated yeast Cryptococcus neoformans following eculizumab therapy and discuss its pathogenesis.