bluuebunny/crossref_metadata_2025_split huggingface dataset:
Role of Environmental, Social, and Governance in achieving the UN Sustainable Development Goals: A special focus on India
Authors: Sarkar Sujay , Moolearambil Sukumaran Nair Madhusoodanan , Datta Arindam 
Published: May 2023

AbstractThis review article investigates how Environmental, Social, and Governance (ESG) can contribute to the achievement of Sustainable Development Goals (SDGs). As environmental concerns increasingly influence investment decisions, the UN's Agenda 2030, encompassing 17 SDGs, 169 targets, and 261 indicators, plays a vital role in the worldwide commitment to sustainable development. The integration of ESG into business strategies and reporting, including India's initiative like the Business Responsibility and Sustainability Report (BRSR) is essential for realizing these national SDGs. 40 relevant ESG indicators align with SDG performance, and adopting ESG standards and sustainability reporting provides a competitive advantage and effective SDG accomplishment for stakeholders and investors.
Arginase deficiency—An unheralded cause of developmental epileptic encephalopathy
Authors: Pavuluri Harini , Jose Manna , Fasaludeen Alfiya , Sundaram Soumya , Radhakrishnan Ashalatha , Banerjee Moinak , Menon Ramshekhar N. 
Published: May 2023

AbstractArginase deficiency, which leads to hyperargininaemia is a rare urea cycle disorder caused by a mutation in the ARG1 gene. It is an under‐recognized cause of pediatric developmental epileptic encephalopathy, with the key coexistent clinical features being developmental delay or regression and spasticity. Detection of ARG1 gene mutation on genetic testing is the confirmatory diagnostic test. However, elevated levels of plasma arginine and low plasma arginase level can be considered as biochemical markers for diagnosis. We present two cases of arginase deficiency with genetically confirmed ARG1 mutation in one and biochemical confirmation in both. As the spectrum of epilepsy in arginase deficiency has been less explored, we attempted to elucidate the novel electroclinical features and syndromic presentations in these patients. Informed consent was obtained from families of patients. Electroclinical diagnosis was consistent with Lennox Gastaut syndrome (LGS) in the first patient while the second patient had refractory atonic seizures with electrophysiological features consistent with developmental and epileptic encephalopathy. Though primary hyperammonaemia is not a consistent feature, secondary hyperammonaemia in the setting of infectious triggers and drugs like valproate (valproate sensitivity) has been well described as also observed in our patient. In the absence of an overt antecedent in a child with spasticity and seizure disorder, with a progressive course consistent with a developmental epileptic encephalopathy, arginase deficiency merits consideration. Diagnosis often has important therapeutic implications with respect to dietary management and choice of the appropriate antiseizure medications.
Examining the components and stability of negative affect in disordered eating frequency
Authors: Legg Nicole K. , Robillard Christina L. , Turner Brianna J. 
Published: May 2023

AbstractObjectiveThere is a limited understanding of the unique components of negative affect that are most important to disordered eating. Our study tested the contributions and stabilities of unique components of negative affect in the frequency of both binge eating and restricted eating. We examined if: (1) symptoms of depression, anxiety and stress share unique, concurrent associations with binge eating and restricted eating, respectively, and if (2) instability of depression, anxiety, and stress predict binge eating and restricted eating, respectively.Method627 first year undergraduate students completed 7 assessments of these constructs across their first academic year. Generalised multilevel modelling was employed.ResultsHigher than average anxiety, but not depression or stress, was concurrently associated with restricted eating. No concurrent associations between negative affect and binge eating were found. Instability of depression, but not anxiety or stress, predicted both binge and restricted eating.ConclusionAnxiety may be a more salient predictor of restricted eating than depression or stress. However, larger monthly changes in depression may confer risk for more frequent binge eating and restricted eating.
A mini review of electrocatalytic upgrading of carbohydrate biomass—System, path, and optimization
Authors: Cheng Shuo , Zhong Heng , Jin Fangming 
Published: May 2023

AbstractUpgrading carbohydrate biomass is a promising process to convert low‐value carbohydrate feedstocks into high‐value chemicals and fuels, which is critical for the development of a sustainable and renewable society. Among the various carbohydrate conversion technologies, electrocatalytic methods have gained increasing research interest due to their mild reaction conditions and easy accessibility. Moreover, electrocatalytic methods utilize water as a green and abundant source of hydrogen and oxygen for either reduction reactions on the cathode or oxidation reactions on the anode. In recent years, significant progress has been made in this field, with the establishment of various systems aimed at enhancing the electrocatalytic conversion of carbohydrates. In this review, recent technologies and results of electrocatalytic conversion of carbohydrates are summarized in two parts: anodic electrocatalytic oxidation (cellulose, 5‐hydroxymethylfurfural [HMF], glucose, and 2‐furfural) and cathodic electrocatalytic reduction (glucose, HMF, and 2‐furfural). Furthermore, future outlooks for improving this field are also proposed.
Momentum exchange modeling for coarsely resolved interfaces in a multifield two‐fluid model
Authors: Meller Richard , Tekavčič Matej , Krull Benjamin , Schlegel Fabian 
Published: May 2023

AbstractMorphology‐adaptive multiphase models are becoming more established for the numerical description of complex gas‐liquid flows adapting dynamically to the local flow morphology. In the present study, two different numerical methods originally designed for distinct flow morphologies are combined, namely the volume‐of‐fluid and the Euler–Euler method. Both edge cases have been proven to be capable of delivering reliable predictions in the respective use cases. The long‐term goal is to improve the prediction of gas‐liquid flows, regardless of the flow regime in a specific application. To capture the system dynamics with a given grid resolution, the flow fields need to be predicted as precise as possible, while the shape of structures such as gas bubbles need to be recovered adequately in topology and shape. The goal is to obtain reliable predictions on intermediate mesh resolutions rather than relying on fine meshes requiring more computational resources. Therefore, a procedure is proposed to locally measure the degree of resolution. With this information, the hydrodynamics in the interface region can be controlled by means of a dedicated interfacial drag formulation in order to improve simulation results across several levels of spatial resolution. A modified formulation of buoyancy is proposed to prevent unphysical oscillations of vertical velocity near a horizontal interface. The functionality is demonstrated in a three‐dimensional case of a gas bubble rising in stagnant liquid and in a co‐current stratified air‐water channel flow in two‐dimensional space. The choice of these different applications demonstrates the general applicability of the proposed model framework.
Three thousand years of river channel engineering in the Nile Valley
Authors: Dalton Matthew , Spencer Neal , Macklin Mark G. , Woodward Jamie C. , Ryan Philippa 
Published: May 2023

AbstractAcross a 1000‐km stretch of the River Nile, from the 1st Cataract in southern Egypt to the 4th Cataract in Sudan, many hundreds of drystone walls are located within active channels, on seasonally inundated floodplains or in now‐dry Holocene palaeochannel belts. These walls (or river groynes) functioned as flood and flow control structures and are of a type now commonly in use worldwide. In the Nile Valley, the structures have been subject only to localised investigations, and none have been radiometrically dated. Some were built within living memory to trap nutrient‐rich Nile silts for agriculture, a practice already recorded in the early 19th century C.E. However, others situated within ancient palaeochannel belts indicate construction over much longer time frames. In this paper, we map the distribution of these river groynes using remote sensing and drone survey. We then establish their probable functions and a provisional chronology using ethnoarchaeological investigation and the ground survey, excavation and radiometric dating of the structures in northern Sudan, focusing on the Holocene riverine landscape surrounding the pharaonic settlement of Amara West (c. 1300–1000 B.C.E.). Finally, we consider the historical and economic implications of this form of hydraulic engineering in the Nile Valley over the past three millennia.
Use of medicinal plants as a remedy against lymphatic filariasis: Current status and future prospect
Authors: Fordjour Fatima A. , Osei‐Poku Priscilla , Genfi Afua K. A. , Ainooson Kwaw G. , Amponsah Kingsley , Arthur Patrick K. , Stephenson G. Richard , Kwarteng Alexander 
Published: May 2023

AbstractDespite the successes achieved so far with the Global Programme to Eliminate Lymphatic Filariasis, there is still an appreciable number of lymphatic filarial patients who need alternative treatment and morbidity management strategies. The unresponsiveness of some cohorts to the drugs used in the mass drug administration program is currently raising a lot of questions and this needs urgent attention. Natural medicinal plants have a long‐standing history of being effective against most disease conditions. Countries such as India have been able to integrate their natural plant remedies into the treatment of lymphatic filarial conditions, and the results are overwhelmingly positive. Components of Azadirachta indica A. Juss, Parkia biglobosa, Adansonia digitata, and Ocimum spp have been shown to have anti‐inflammatory, anticancerous, and antimicrobial activities in animal models. Therefore, this review calls for attention toward the use of natural plant components as an alternate treatment against lymphatic filariasis to help reduce the World Health Organization's burden of providing drugs for people in need of treatment every year.
An assessment of the relationship between national rates of Covid‐19 incidence and mortality as reported to an international comparison database: An ecological study
Authors: Shokri Azad , Mahmoodi Hassan , Piroozi Bakhtiar , Moradi Yousef , Moradpour Farhad , Moradi Ghobad , Ebrazeh Ali , Daftarifard Parisa 
Published: May 2023

AbstractBackground and AimsMaking a judgment only based on formal national reports can be misleading. We aimed to assess the relationship between countries' development indicators and reported coronavirus disease 2019 (Covid‐19)‐related incidences and death.MethodsCovid‐19 related incidence and death cases were extracted from the updated Humanitarian Data Exchange Website on October 8, 2021. Univariable and multivariable negative binomial regression were utilized to investigate the relationship between development indicator and incidence and mortality from Covid‐19 by calculating the Incidence rate ratio (IRR), mortality rate ratio (MRR), and fatality risk ratio (FRR).ResultsVery high human development index (HDI) compared with low HDI (IRR:3.56; MRR:9.04), the proportion of physicians (IRR:1.20; MRR:1.16), besides extreme poverty (IRR:1.01; MRR:1.01) were independently correlated with the mortality and incidence rate of Covid‐19. Very high HDI and population density were inversely correlated with the fatality risk (FRRs of 0.54 and 0.99). The cross‐continental comparison shows Europe and the North Americas, had significantly higher incidence and mortality rates with IRR of 3.56 and 1.84 as well as MRRs of 6.65 and 3.62, respectively. Also, they inversely correlated with the fatality (FRR:0.84 and 0.91, respectively).ConclusionA positive correlation between the fatality rate ratio based on countries' development indicators and the reverse for the incidence and mortality rate was found. Developed countries with sensitive healthcare systems can diagnose infected cases as soon as possible. Also, the mortality rate of Covid‐19 will be accurately registered and reported. Due to more access to diagnostic tests, patients are diagnosed at the initial stages and will have a better opportunity to receive treatment. This leads to higher reports of incidence/and/or mortality rates and lower fatality of COVID‐19. In conclusion, more Covid‐19 incidence and mortality cases in developed countries can result from a more comprehensive care system and a more accurate recording procedure.
Predicting second breast cancer among women with primary breast cancer using machine learning algorithms, a population‐based observational study
Authors: Syleouni Maria‐Eleni , Karavasiloglou Nena , Manduchi Laura , Wanner Miriam , Korol Dimitri , Ortelli Laura , Bordoni Andrea , Rohrmann Sabine 
Published: May 2023

AbstractBreast cancer survivors often experience recurrence or a second primary cancer. We developed an automated approach to predict the occurrence of any second breast cancer (SBC) using patient‐level data and explored the generalizability of the models with an external validation data source. Breast cancer patients from the cancer registry of Zurich, Zug, Schaffhausen, Schwyz (N = 3213; training dataset) and the cancer registry of Ticino (N = 1073; external validation dataset), diagnosed between 2010 and 2018, were used for model training and validation, respectively. Machine learning (ML) methods, namely a feed‐forward neural network (ANN), logistic regression, and extreme gradient boosting (XGB) were employed for classification. The best‐performing model was selected based on the receiver operating characteristic (ROC) curve. Key characteristics contributing to a high SBC risk were identified. SBC was diagnosed in 6% of all cases. The most important features for SBC prediction were age at incidence, year of birth, stage, and extent of the pathological primary tumor. The ANN model had the highest area under the ROC curve with 0.78 (95% confidence interval [CI] 0.750.82) in the training data and 0.70 (95% CI 0.61‐0.79) in the external validation data. Investigating the generalizability of different ML algorithms, we found that the ANN generalized better than the other models on the external validation data. This research is a first step towards the development of an automated tool that could assist clinicians in the identification of women at high risk of developing an SBC and potentially preventing it.
Radiological response of leptomeningeal metastases according to revised RANO criteria is associated with overall survival in breast cancer patients
Authors: Griguolo Gaia , Aldegheri Vittoria , Bottosso Michele , Pittaro Alice , Caumo Francesca , Guarascio Maria Cristina , Pouderoux Stéphane , Busato Fabio , Miglietta Federica , Jacot William , Dieci Maria Vittoria , Darlix Amelie , Guarneri Valentina 
Published: May 2023

AbstractAssessment of treatment response in patients (pts) with leptomeningeal metastases (LM) represents a significant challenge and standardized criteria are needed. In 2017, the RANO LM Working Group proposed a standardized scorecard to evaluate MRI findings (further simplified in 2019). Here, we aim to validate the prognostic impact of response to treatment assessed using this tool in a multicentric cohort of breast cancer (BC) pts. Pts with BC‐related LM diagnosed at two institutions between 2005 and 2018 were identified. Baseline and follow‐up MRI scans were centrally reviewed and response assessment was evaluated using 2019 revised RANO LM criteria. A total of 142 pts with BC‐related LM and available baseline brain MRI imaging were identified; 60 of them had at least one follow‐up MRI. In this subgroup, median overall survival (OS) was 15.2 months (95%CI 9.5‐21.0). At first re‐evaluation, radiological response by RANO criteria was: complete response (CR) in 2 pts (3%), partial response (PR) in 12 (20%), stable disease (SD) in 33 (55%) and progression of disease (PD) in 13 (22%). Median OS was 31.1 months (HR 0.10, 95%CI 0.01‐0.78) in pts with CR, 16.1 months (HR 0.41, 95%CI 0.17‐0.97) in pts with PR, 17.9 months (HR 0.45, 95%CI 0.22‐0.91) in pts with SD and 9.5 months in pts with PD (P = .029). A second blinded evaluation showed a moderate interobserver agreement (K = 0.562). Radiological response according to 2019 RANO criteria is significantly associated with OS in pts with BC‐related LM, thus supporting the use of this evaluation tool both in trials and clinical practice.
Broadscale distribution, abundance, and habitat associations of the invasive Asian clam (Corbicula fluminea) in the lower Columbia River, USA
Authors: Robb‐Chavez Salvador B. , Bollens Stephen M. , Rollwagen‐Bollens Gretchen , Counihan Timothy D. 
Published: May 2023

AbstractThe Asian clam, Corbicula fluminea, is an invasive freshwater bivalve that has established populations across the globe and is known to have deleterious effects on natural and human systems. Yet, despite being present in the Columbia River (CR) for nearly a century, little is known about this invader's basic biology and ecology in this large river system. Thus, we undertook a field study to assess its (i) broadscale distribution and abundance, and (ii) associations with habitat characteristics in the lower CR. During 2019–2020, C. fluminea were collected from 27 shore‐based stations spanning 481 river kilometers of the lower CR, along with several habitat characteristics (bank slope, temperature, dissolved oxygen, pH, salinity, conductivity, chlorophyll‐a concentration, and sediment composition and % organic matter [OM]). C. fluminea abundance ranged from 0 to 430 ind. m−2. Most sites with abundances >100 ind. m−2 were located downstream of Bonneville Dam, whereas most sites with abundances <100 ind. m−2 were located upstream. Generalized linear models predicting the abundance of C. fluminea indicated significantly positive correlations with water temperature and % sand, and negative correlations with bank slope and sedimentary % OM. We also reviewed the global literature on abundance and habitat associations of C. fluminea and compared this with our own results. Our investigation represents the greatest spatial extent at which C. fluminea has been studied in the CR and our results provide a better understanding of the basic biology and ecology of this global invader, as well as provide natural resource managers with information on habitat conditions favorable for this invasive bivalve within temperate river ecosystems.
Population structure and dietary plasticity of four invasive populations of the topmouth gudgeon Pseudorasbora parva
Authors: Nocita Annamaria , La Sala Giuseppe , Busatto Thomas , Santini Giacomo , Balzani Paride 
Published: May 2023

AbstractThe topmouth gudgeon Pseudorasbora parva is one of the worst invasive species worldwide and is considered to be highly plastic in terms of its phenotype but also behavioral ecology. Here, we analyzed the population structure and the morphological and dietary plasticity of four populations of P. parva across the four seasons within the Arno River basin in Central Italy. We found that the studied populations were morphologically different, suggesting multiple introductions or adaptation to different environmental conditions. In all populations, males were bigger and, overall, more frequent than females. The gonadosomatic index showed a similar pattern across all populations, with higher spring and summer values, indicating a long reproductive period. The diet of P. parva considerably varied across populations and seasons, suggesting a high degree of spatio‐temporal trophic plasticity. Diet breadth varied among seasons, being more specialized in spring and summer and more opportunistic during autumn and winter. Our results highlight high trophic plasticity in the invasive populations of P. parva, potentially impacting multiple native taxa.
Bioactive impact of manuka honey and bone char incorporated into gelatin and chitosan cryogels in a rat calvarial fracture model
Authors: Robertson E. M. , Hixon K. R. , McBride‐Gagyi S. H. , Sell S. A. 
Published: May 2023

AbstractBone tissue engineered scaffolds are designed to mimic the natural environment for regeneration when typical healing is inhibited. Autografts are the current gold standard for treatment but are limited by available bone and supplementary surgical sites that broaden complications and comorbidities. Cryogels are an ideal scaffold in bone regeneration due to their mechanical integrity and marcoporous structure that elicits angiogenesis and subsequently new bone tissue formation. To aid in bioactivity and osteoinductivity, manuka honey (MH) and bone char (BC) were added to gelatin and chitosan cryogels (CG). Manuka honey has powerful antimicrobial properties to aid against graft infection, and bone char is composed of 90% hydroxyapatite, a well‐studied bioactive material. These additives are natural, abundant, easy to use, and cost effective. CG cryogels incorporated with either BC or MH, and plain CG cryogels were implanted into rat calvarial fracture models for cortical bone regeneration analysis. We found indication of bioactivity with both bone char and manuka honey through the presence of woven bone structure in histology stains and micro computed tomography (microCT) data. Overall, plain CG cryogels supported greater bone regeneration capabilities than the BC or MH incorporated cryogels due to a lack of advanced organized tissue formation and collagen deposition after 8 weeks of implantation; however, future work should explore varying additive concentrations and delivery methods to further assess additive potential.
Synthesis, docking studies, in vitro cytotoxicity evaluation and DNA damage mechanism of new tyrosine‐based tripeptides
Authors: Çalışkan Eray , Kaplan Alpaslan , Şekerci Güldeniz , Çapan İrfan , Tekin Suat , Erkan Sultan , Koran Kenan , Sandal Süleyman , Görgülü Ahmet O. 
Published: May 2023

AbstractPeptides are one of the leading groups of compounds that have been the subject of a great deal of biological research and still continue to attract researchers' attention. In this study, a series of tripeptides based on tyrosine amino acids were synthesized by the triazine method. The cytotoxicity properties of all compounds against human cancer cell lines (MCF‐7), ovarian (A2780), prostate (PC‐3), and colon cancer cell lines (Caco‐2) were determined by the 3‐[4,5‐dimethylthiazol‐2‐yl]‐2,5 diphenyl tetrazolium bromide assay method, and % cell viability and logIC50 values of the compounds were calculated. Significant decreases in cell viability were observed in all cells (p < 0.05). The comet assay method was used to understand that the compounds that showed a significant decrease in cell viability had this effect through DNA damage. Most of the compounds exhibited cytotoxicity by DNA damage mechanism. Besides, their interactions between investigated molecule groups with PDB ID: 3VHE, 3C0R, 2ZCL, and 2HQ6 target proteins corresponding to cancer cell lines, respectively, were investigated by docking studies. Finally, molecules with high biological activity against biological receptors were determined by ADME analysis.