bluuebunny/crossref_metadata_2025_split huggingface dataset:
3-D-Analyse von posttraumatischen Tibiaschaftfehlstellungen und deren Korrektur anhand der gesunden Gegenseite
Authors: Viehöfer Arnd F. , Wirth Stephan H. 
Published: September 2023

Zusammenfassung
Grundlagen
Die 3‑D-Analyse und Umsetzung mit patientenindividuellen Schnitt- und Repositionsblöcken ermöglicht die Korrektur komplexer Tibiafehlstellungen. Die Korrektur kann anhand der Gegenseite oder eines statistischen Modells geplant werden. Patientenspezifische 3‑D-gedruckte Schnittführungsblöcke ermöglichen eine präzise Osteotomie, und Repositionsblöcke helfen, eine anatomische Reposition zu erreichen. Je nach Art und Ausmaß der Korrektur muss eine Fibulaosteotomie erwogen werden, um eine Korrektur in der gewünschten Reposition zu erreichen.

Kontraindikationen
a) Schlechte Weichteilsituation, Vorsicht insbesondere bei adhärenter Haut und Lappenplastiken im Zugangsbereich; b) Infektionen; c) periphere arterielle Verschlusskrankheit (Stadium III und IV, kritischer transkutaner Sauerstoffpartialdruck tcpO2 im Operationsgebiet); d) allgemeine Kontraindikation einer Operation.

Operationstechnik
Vor der Operation wird ein 3‑D-Modell beider Unterschenkel anhand von CT-Daten erstellt. Analyse der Deformität anhand der Gegenseite im 3‑D-Computermodell (CASPA) und Planung der Osteotomie. Falls die Gegenseite eine Fehlstellung zeigt, kann ein statistisches Modell benutzt werden. Drucken der patientenspezifischen Schnittblöcke aus Nylon (PA2200) für die Osteotomie und Reposition. Die Operation erfolgt in Rückenlagerung, Antibiotikaprophylaxe präoperativ, Oberschenkelblutsperre, welche bei Bedarf aktiviert wird. Ventrolateraler Zugang zur Tibia. Anbringen des patientenspezifischen Schnittblocks, Durchführung der Osteotomie. Reposition über den Repositionsblock und Fixieren mittels medialer Platte. Falls die Fibula die Reposition behindert, erfolgt eine Fibulaosteotomie in der Regel über einen separaten lateralen Zugang. Je nach Präferenz des Operateurs kann diese ebenfalls mit patientenspezifischen Schnittblöcken erfolgen. Verschluss der Wunde.

Postoperatives Management
Kompartmentüberwachung. Passive Mobilisation des oberen Sprunggelenks aus dem Gips, sobald die Wundheilung fortgeschritten ist. Teilbelastung im abnehmbaren Unterschenkelgips für mindestens 6 bis 12 Wochen, abhängig von der routinemäßig durchgeführten Röntgenkontrolle 6 Wochen postoperativ. Bis zur Gipsabnahme Thromboseprophylaxe mittels niedermolekularen Heparins.

Ergebnisse
Die patientenspezifische Korrektur der Fehlheilung ermöglicht im Allgemeinen eine gute Korrektur. Für die distalen Korrekturen der Tibia wurden gute Ergebnisse erzielt. Für die Korrektur von Tibiaschaftdeformitäten sind die endgültigen Ergebnisse noch ausstehend. Vorläufige Ergebnisse zeigen eine gute Machbarkeit mit einer Pseudarthrosenrate von 10 % ohne postoperative Infekte.
Predation of baitfishes associated with whale sharks at Ningaloo Reef
Authors: Barry Christine , Gleiss Adrian C. , Ferreira Luciana C. , Thums Michele , Davis Randall W. , Fuiman Lee A. , Roche Naomi R. , Meekan Mark G. 
Published: September 2023

AbstractBaitfishes may aggregate around megafauna such as whale sharks (Rhincodon typus) to gain protection from larger predatory fishes. Here, we used videos from deployments of animal-borne cameras on whale sharks and provided by tourism operators at Ningaloo Reef in Western Australia to document large schools of trevally (Carangidae spp.) consuming entire schools of baitfishes (Carangidae spp.) swimming with whale sharks within 2–45 s. These videos showed that small baitfishes are still very vulnerable to predatory fishes when accompanying whale sharks, refuting the hypothesis that whale sharks provide baitfishes shelter from predators. It thus seems more likely that the association between whale sharks and baitfishes may confer other advantages such as reduced costs of locomotion and/or enhanced feeding opportunities for baitfishes rather than protection from predation.
Physical exercise as a treatment for persisting symptoms post-COVID infection: review of ongoing studies and prospective randomized controlled training study
Authors: Kogel Alexander , Machatschek Moritz , Scharschmidt Ronja , Wollny Carolin , Lordick Florian , Ghanem Mohamed , Laufs Ulrich , Fikenzer Sven 
Published: September 2023

Abstract
Background and purpose
No evidence-based treatment is available for patients with persisting symptoms post-COVID-19 infection. We hypothesized that physical exercise may represent a safe and effective treatment option for post-COVID.

Methods
We performed a systematic search of the literature that revealed a lack of randomized training studies in patients post-COVID. Based on these findings, a prospective randomized controlled study with open-label and blinded endpoint evaluation was designed. 272 patients with symptoms of fatigue persisting over 6 weeks post-COVID infection were screened. Patients with pathological cardiovascular findings were excluded. 57 patients consented and were randomized to 4 weeks of supervised personalized strength and endurance training or usual care. The follow-up period was 3 and 6 months.

Results
There were no adverse events related to the training. Spiroergometry of the training group showed a significantly higher increase in VO2peak (10.0 ± 12.7% vs. 0.1 ± 8.9%, p < 0.01, respectively) and oxygen pulse (9.8 ± 10.8% vs. 0.0 ± 13.9%, p < 0.05, respectively). Parameters of the Multidimensional Fatigue Inventory-20, McGill Quality of Life Questionnaire, and Post-COVID-19 Functional Status were improved after 4 weeks in both groups. In the follow-up period, the total physical activity per week was significantly greater in the exercise group than in controls (1280 ± 1192 min vs. 644 ± 554 min, p < 0.05, respectively). The improvements in fatigue and quality of life were not statistically different between the training and usual care groups.

Conclusion
Exercise is safe and improves maximal exercise capacity in post-COVID patients. Fatigue and quality of life improve over time in individuals that are willing to participate in a training study irrespective of their allocation.

Registration
German Clinical Trials Register: DRKS00026686. Date of registration: 27.09.2021.

Graphical abstract
Patients’ experiences of a suppoRted self-manAGeMent pAThway In breast Cancer (PRAGMATIC): quality of life and service use results
Authors: Jenkins V , Matthews L , Solis-Trapala I , Gage H , May S , Williams P , Bloomfield D , Zammit C , Elwell-Sutton D , Betal D , Finlay J , Nicholson K , Kothari M , Santos R , Stewart E , Bell S , McKinna F , Teoh M 
Published: September 2023

Abstract
Purpose
To describe trends and explore factors associated with quality of life (QoL) and psychological morbidity and assess breast cancer (BC) health service use over a 12-month period for patients joining the supported self-management (SSM)/patient-initiated follow-up (PIFU) pathway.

Methods
Participants completed questionnaires at baseline, 3, 6, 9 and 12 months that measured QoL (FACT-B, EQ 5D-5L), self-efficacy (GSE), psychological morbidity (GHQ-12), roles and responsibilities (PRRS) and service use (cost diary).

Results
99/110 patients completed all timepoints; 32% (35/110) had received chemotherapy. The chemotherapy group had poorer QoL; FACT-B total score mean differences were 8.53 (95% CI: 3.42 to 13.64), 5.38 (95% CI: 0.17 to 10.58) and 8.00 (95% CI: 2.76 to 13.24) at 6, 9 and 12 months, respectively. The odds of psychological morbidity (GHQ12 >4) were 5.5-fold greater for those treated with chemotherapy. Financial and caring burdens (PRRS) were worse for this group (mean difference in change at 9 months 3.25 (95% CI: 0.42 to 6.07)). GSE and GHQ-12 scores impacted FACT-B total scores, indicating QoL decline for those with high baseline psychological morbidity. Chemotherapy patients or those with high psychological morbidity or were unable to carry out normal activities had the highest service costs. Over the 12 months, 68.2% participants phoned/emailed breast care nurses, and 53.3% visited a hospital breast clinician.

Conclusion
The data suggest that chemotherapy patients and/or those with heightened psychological morbidity might benefit from closer monitoring and/or supportive interventions whilst on the SSM/PIFU pathway. Reduced access due to COVID-19 could have affected service use.
Tibialis posterior tendon entrapment in posterior malleolar and pilon injuries of the ankle: a retrospective analysis
Authors: Aamir Junaid , Syziu Anxhela , Andritsos Loukas , Caldwell Robyn , Mason Lyndon 
Published: September 2023

Abstract
Background
The Tibialis Posterior tendon (TPT) is the only tendon to encounter the distal tibia and is therefore at greatest risk of injury in fractures of the distal tibia. Although TPT injury has been reported rarely with injuries around the ankle, they often have been missed and present late.

Aim
Our aim was to analyse the rate to TPT entrapment in fractures involving the posterior tibia, i.e. Pilon (PLM) and posterior malleolar fractures (PMF).

Methods
A retrospective analysis of PMF and Pilon fractures over an 8-year period was undertaken. Patients who had undergone surgical fixation of their PMF or PLM were identified from 2014 to 2022, using our prospectively collected database. Any fracture which had undergone a preoperative CT was included. Analysis of their pre-operative CT imaging was utilised to identify TPT entrapment, where if < 50% of the tendon cross section was present in the fracture site, this was denoted as a minor entrapment and if ≥ 50% of the tendon was present in the fracture site was denoted as major.

Results
A total of 363 patients were identified for further analysis, 220 who had a PMF and 143 with PLM injury. The incidence of TPT entrapment was 22% (n = 79) with 64 minor and 15 major entrapments. If the fracture line entered the TPT sheath, there was a 45% rate (72/172) of entrapment as compared to 3.7% (7/190) in fractures not entering the sheath (p < .001). There was no significant difference in TPT entrapment in PMF as compared to PML (p = 0.353).

Conclusion
In our assessment, we found significant prevalence of 22% of TPT entrapment in fractures involving the posterior tibia. PMF and PLF had no statistically significant difference in the rate of TPT entrapment. Additionally, we found that there was a significant risk of TPT entrapment when the CT images display the fracture line entering the tendon sheath. We recommend that surgeons consider taking care assessing pre-operative imaging to seek to identify the TPT and to assess intraoperatively where entrapment does occur.
Okuläre Nebenwirkungen von Dupilumab – Übersichtsarbeit und Therapieempfehlung der „Kommission für Trockenes Auge und Oberflächenerkrankungen“ der Österreichischen Ophthalmologischen Gesellschaft (ÖOG)
Authors: Woltsche Nora , Aschauer Julia , Boldin Ingrid , Garhöfer Gerhard , Kaya-Reindl Semira , Moussa Sarah , Nepp Johannes , Palkovits Stefan , Wimmer-Orlowski Eva , Horwath-Winter Jutta 
Published: September 2023

ZusammenfassungDupilumab (Dupixent®, Sanofi and Regeneron Pharmaceuticals), ein humaner monoklonaler Antikörper gegen die IL-4-Rezeptor-α-Untereinheit von IL‑4 und IL-13, ist mittlerweile zur Therapie der atopischen Dermatitis ab dem 6. Lebensmonat zugelassen. In Real-World-Studien konnte gezeigt werden, dass in bis zu 62 % aller mit Dupilumab behandelten Patient*innen mit atopischer Dermatitis Nebenwirkungen im Sinne von Augenoberflächenerkrankungen auftreten. In den meisten Fällen sind diese mild bis moderat ausgeprägt und präsentieren sich als (Blepharo‑)Konjunktivitiden oder superfizielle Keratitiden, welche mit ophthalmologischer Lokaltherapie ohne Reduktion bzw. Absetzen von Dupilumab zumeist suffizient in den Griff zu bekommen sind. Es gibt jedoch auch Einzelfälle von schwerwiegenden okulären Nebenwirkungen wie Vernarbungen an der Augenoberfläche oder an den Lidern sowie Hornhautulzera bis hin zur Hornhautperforation. Dieser Artikel soll wichtige Hintergrundinformationen zu den okulären Nebenwirkungen unter Dupilumab liefern und eine praxisrelevante Therapieempfehlung für Ophthalmolog*innen darstellen.
Do Lower Search Costs Benefit Intermediaries?
Authors: Li Muxin 
Published: September 2023

AbstractIntermediaries—such as Amazon, Alibaba Group, and Walmart—play critical roles in digital markets: This paper proposes a model for analyzing how search cost affects their market outcomes. Distinguished from existing search literature, we introduce network effects to the market by allowing buyers to have positive preferences for product variety. In addition, we relax the exogenous demand and supply assumptions in the conventional search literature to study how search affects participation on both sides of the market. Through the model, we focus on studying and comparing two important types of intermediary: the two-sided platform; and the one-sided retailer. We find that reducing search costs does not necessarily increase the profit of both intermediary types. Furthermore, its influences are highly varied—depending on both the type of intermediary and its buyers’ preferences for variety.
Solar Energetic-Particle-Associated Coronal Mass Ejections Observed by the Mauna Loa Solar Observatory Mk3 and Mk4 Coronameters
Authors: Richardson I. G. , St. Cyr O. C. , Burkepile J. T. , Xie H. , Thompson B. J. 
Published: September 2023

AbstractWe report on the first comprehensive study of the coronal mass ejections (CMEs) associated with $\sim 25\text{ MeV}$
∼
25
MeV
solar energetic-proton (SEP) events in 1980 – 2013 observed in the low/inner corona by the Mauna Loa Solar Observatory (MLSO) Mk3 and Mk4 coronameters. Where possible, these observations are combined with space-based observations from the Solar Maximum Mission C/P, P78-1 SOLWIND, or SOHO/LASCO coronagraphs. The aim of the study is to understand directly measured (rather than inferred from proxies) CME motions in the low to midcorona and their association with SEP acceleration, and hence attempt to identify early signatures that are characteristic of SEP acceleration in ground-based CME observations that may be used to warn of impending SEP events. Although we find that SEP events are associated with CMEs that are on average faster and wider than typical CMEs observed by MLSO, a major challenge turns out to be determining reliable estimates of the CME dynamics in the low corona from the 3-min cadence Mk3/4 observations since different analysis techniques can produce inconsistent results. This complicates the assessment of what early information on a possible SEP event is available from these low-coronal observations.
Pharmacological characterization of P2Y receptor subtypes – an update
Authors: von Kügelgen Ivar 
Published: September 2023

AbstractP2Y receptors are G-protein-coupled receptors (GPCRs) for extracellular nucleotides. There are eight mammalian P2Y receptor subtypes (P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, P2Y13, and P2Y14). The widely expressed P2Y receptors play important roles in physiology and pathophysiology. This review summarizes the use of pharmacological tools to characterize the P2Y receptor subtypes involved in these responses. MRS2500 is a potent and selective antagonist acting at the P2Y1 receptor. AR-C118925 is useful for the selective antagonism of the P2Y2 receptor. PSB16133 blocks the P2Y4 receptor, MRS2578 is an antagonist at the P2Y6 receptor and NF157 as well as NF340 block the P2Y11 receptor. ADP-induced platelet aggregation is mediated by P2Y1 and P2Y12 receptors. A number of compounds or their active metabolites reduce ADP-induced platelet aggregation by blocking the P2Y12 receptor. These include the active metabolites of the thienopyridine compounds clopidogrel and prasugrel, the nucleoside analogue ticagrelor and the nucleotide analogue cangrelor. PSB0739 is also a potent antagonist at the P2Y12 receptor useful for both in vitro and in vivo studies. MRS2211 and MRS2603 inhibit P2Y13 mediated responses. PPTN is a very potent antagonist at the P2Y14 receptor.
Geroprotective interventions converge on gene expression programs of reduced inflammation and restored fatty acid metabolism
Authors: Landsberger Tomer , Amit Ido , Alon Uri 
Published: September 2023

AbstractUnderstanding the mechanisms of geroprotective interventions is central to aging research. We compare four prominent interventions: senolysis, caloric restriction, in vivo partial reprogramming, and heterochronic parabiosis. Using published mice transcriptomic data, we juxtapose these interventions against normal aging. We find a gene expression program common to all four interventions, in which inflammation is reduced and several metabolic processes, especially fatty acid metabolism, are increased. Normal aging exhibits the inverse of this signature across multiple organs and tissues. A similar inverse signature arises in three chronic inflammation disease models in a non-aging context, suggesting that the shift in metabolism occurs downstream of inflammation. Chronic inflammation is also shown to accelerate transcriptomic age. We conclude that a core mechanism of geroprotective interventions acts through the reduction of inflammation with downstream effects that restore fatty acid metabolism. This supports the notion of directly targeting genes associated with these pathways to mitigate age-related deterioration.
Allah, Bread, Freedom: Turkey’s Muslim others and transnational mosques in Europe
Authors: Kurt Mashuq 
Published: September 2023

AbstractScholarship on political Islam has often addressed settings where Islamist movements and political parties operate as anti-colonial and oppositional entities. On the other hand, this article focuses on a less explored aspect of Islamist governmentalities in a case when Islamism becomes a part of the governing canon and rules over its Muslim others. I investigate situations where Islamist politics incorporates neo-imperial, nationalist, and colonial practices in creating a desired Muslim ummah at home and abroad. I explore marginalized critical discourses and praxes within this imagined Muslim ummah in Turkey and examine its transnational reverberations among the Kurdish and Turkish communities and mosques in Europe. In other words, I examine the dialectical relation between the formation of the Turkish Islamist canon and its non-Western critiques that comes from within and the margins through protests and critiques of Anti-capitalist Muslims in Turkey; examples of Civil Friday prayers (Sivil Cuma namazları) of the Kurdish imams; and the reconfiguration of Kurdish mosques of liberation in Europe. In doing so, I present how religious practices and discourses are instrumentalized for Islamist colonial governmentalities on the one hand but also serve as a decolonial critique to deconstruct contemporary Muslimness and open room for a plurality of Muslim perspectives excluded from the overly militarized and nationalist rhetoric espoused in Turkish Islamist discourses and practices.
Die MotOr-Skala: ein Kurzfragebogen zur Erfassung von Selbstwirksamkeitserwartungen und Enthusiasmus als Teilaspekte motivationaler Orientierungen von Lehrkräften in den Naturwissenschaften
Authors: Milius Marvin , Lopper Elisa , Hoppe Annekatrin , Upmeier zu Belzen Annette , Nitz Sandra 
Published: September 2023

ZusammenfassungSelbstwirksamkeitserwartungen und Lehrkräfteenthusiasmus als Teilaspekte motivationaler Orientierung einer Lehrkraft sind von Bedeutung für die Unterrichtsqualität, die Lernleistung der Schüler:innen sowie für arbeitsbezogene Merkmale der Lehrperson wie Jobzufriedenheit oder Stressempfinden. Im Beitrag wird ein Kurzfragebogen zur Erfassung der motivationalen Orientierungen (MotOr-Skala) im naturwissenschaftlichen Unterricht präsentiert, der eine adaptierte und zeitökonomische Version bereits validierter Messinstrumente darstellt. Die MotOr-Skala wurde ausgehend von Langskalen entwickelt und bildet die Subskalen ‚allgemeine Selbstwirksamkeitserwartung‘, ‚domänenspezifische Selbstwirksamkeitserwartung‘, ‚Fachenthusiasmus‘ und ‚Unterrichtsenthusiasmus‘ mit jeweils drei Items ab. Das Messinstrument wurde durch eine konfirmatorische Faktorenanalyse mit Daten von 152 Biologielehrkräften validiert. Die Prüfung der internen Konsistenzen sowie die Itemanalysen zeigen hinreichende und reliable Werte. Positive Korrelationen der MotOr-Skala mit der durch die Lehrkräfte selbsteingeschätzten Unterrichtsqualität geben Hinweise für die Kriteriumsvalidität der Skala. Inhaltliche Validität wurde durch ein Rating von elf Expert:innen festgestellt. Damit liegt ein Kurzfragebogen zur validen Erfassung der motivationalen Orientierungen bei Lehrkräften für die naturwissenschaftlichen Fächer vor, der zeitökonomisch einsetzbar ist.
A New Efficient Explicit Deferred Correction Framework: Analysis and Applications to Hyperbolic PDEs and Adaptivity
Authors: Micalizzi Lorenzo , Torlo Davide 
Published: September 2023

Abstract
The deferred correction (DeC) is an iterative procedure, characterized by increasing the accuracy at each iteration, which can be used to design numerical methods for systems of ODEs. The main advantage of such framework is the automatic way of getting arbitrarily high order methods, which can be put in the Runge-Kutta (RK) form. The drawback is the larger computational cost with respect to the most used RK methods. To reduce such cost, in an explicit setting, we propose an efficient modification: we introduce interpolation processes between the DeC iterations, decreasing the computational cost associated to the low order ones. We provide the Butcher tableaux of the new modified methods and we study their stability, showing that in some cases the computational advantage does not affect the stability. The flexibility of the novel modification allows nontrivial applications to PDEs and construction of adaptive methods. The good performances of the introduced methods are broadly tested on several benchmarks both in ODE and PDE contexts.
Some new restricted maximal operators of Fejér means of Walsh–Fourier series
Authors: Baramidze Davit , Baramidze Lasha , Perssson Lars-Erik , Tephnadze George 
Published: September 2023

AbstractIn this paper, we derive the maximal subspace of natural numbers $$\left\{ n_{k}:k\ge 0\right\} ,$$

n
k

:
k
≥
0

,

such that the restricted maximal operator, defined by $${\sup }_{k\in {\mathbb {N}}}\left| \sigma _{n_{k}}F\right| $$

sup

k
∈
N

σ

n
k

F

on this subspace of Fejér means of Walsh–Fourier series is bounded from the martingale Hardy space $$H_{1/2}$$

H

1
/
2

to the Lebesgue space $$L_{1/2}.$$

L

1
/
2

.

The sharpness of this result is also proved.
Venture Capital Law in Cambodia: Engineer the Regulatory Framework to Promote the Startup Ecosystem
Authors: Soeun Tharith 
Published: September 2023

AbstractAs the startup ecosystem emerges, Cambodia requires a distinct set of legal frameworks to promote many regulatory aspects to boost national innovation and strengthen the connection of key players in the ecosystem. One of them is financial support for startups, ‘Venture Capital Law’. Therefore, this paper studies the current existing legal framework of Venture Capital (VC) in Cambodia, key bottlenecks that VC encountered, comparative analysis with other countries such as the United States, Japan, and China, and then propose new regulatory frameworks which solve the key bottlenecks and aim to optimise the growth of a startup ecosystem. The finding is that different stages of VC present different bottlenecks such as fundraising (funding source), startup investment (investment readiness of the startup, and deal structure), and exit (immature the capital market for startup's IPO and lack of regulations for Merger and Acquisition (M&A)). The new regulatory frameworks should endorse the use of pension funds as a source of VC funds in the future, encourage private corporations to invest in startup causes, include regulations to promote the readiness of founders, encourage the use of convertible notes, and fasten the regulation governing M&A with the balance of antitrust law.