bluuebunny/crossref_metadata_2025_split huggingface dataset:
Insulin and toll-like receptor 4 interaction in the rat model of Parkinson’s disease induced by lipopolysaccharide
Authors: Hemmati Fatemeh , Valian Neda , Ahmadiani Abolhassan , Mohamed Zahurin , Ali Raymond Azman , Ibrahim Norlinah Mohamed , Shirazi Seyed Farshad Hosseini 
Published: March 2023

AbstractToll-like receptor (TLR) 4 is involved in neuroinflammatory processes – both in peripheral tissues and the central nervous system. Pro-inflammatory cytokines production due to over activation of TLR4 interfere with insulin signaling elements and induce insulin resistance. Regarding the critical roles of TLR4 and insulin signaling in the pathogenesis of Parkinson’s disease (PD), in the present study the TLR4/insulin receptor interaction was assessed in a neuroinflammation model of PD. LPS was injected in the right striatum of male Wistar rats (20µg/rat). Insulin (2.5IU/day), insulin receptor antagonist (S961; 6.5nM/kg) or TLR4 antibody (Resatorvid (TAK242); 0.01µg/rat) were administered intracerebroventricular (ICV) for 14 days. Insulin and TAK242 were also simultaneously injected in a distinct group. Behavioral assessment was performed using rotarod, apomorphine-induced rotation and cylinder tests. The levels of α-synuclein, TLR4 and insulin signaling were measured in the striatum. LPS impaired motor performance of the animals, and increased the levels of α-synuclein and TLR4. Furthermore, it reduced mRNA levels of IRS1 and IRS2 and enhanced GSK3β mRNA and protein, indicating the development of insulin resistance. Treatment with insulin, TAK 242, and combination therapy were able to restore insulin signaling and reduce α-synuclein and TLR4, which led to improvement of motor deficits. The findings indicate that LPS can reduce insulin sensitivity through, at least in part, neuroinflammation and TLR4 overexpression, which leads to motor impairments. Suppression of TLR4 and activation of insulin receptor improve motor behaviors by restoration of these changes, suggesting TLR4 and insulin receptors are good therapeutic targets for PD modification.
Equilibrium and Kinetic Study on the Abolition of Hexavalent Chromium from Aqueous Solutions Utilizing Xanthated Tea Waste
Authors: Bista Dinesh , Joshi Padam , Chand Priyanka 
Published: March 2023

Abstract
Heavy metal removal is critically necessary to prevent water pollution. At various initial hexavalent chromium concentrations, adsorbent dosages, pHs, and contact periods, the removal of hexavalent chromium from aqueous solutions onto Xanthated Tea Waste was investigated. FTIR and XRD techniques were used to characterize the adsorbent. Hexavalent chromium was initially removed from aqueous solutions with an increase in adsorbent dosage and contact time, but it was shown that the adsorption of Cr (VI) was best at a contact period of 120 min and an adsorbent dose of 100 mg/L. In a similar manner, the amount of hexavalent chromium eliminated from the aqueous solutions increased as the hexavalent chromium concentration grew and decreased as the solution's pH increased, with pH 2.0 being the ideal. Using a pseudo second-order model, the kinetics of hexavalent chromium adsorption onto modified tea trash was studied. The adsorption equilibrium data were modeled using Langmuir isotherm models. The equilibrium results for the elimination of hexavalent chromium by modified tea trash were well represented by the Langmuir isotherm model. According to the isotherm analysis, the adsorption equilibrium fit the Langmuir isotherm well. At pH 2.0, the obtained maximum adsorption capacity was around 82%. According to the findings, chromium-containing aqueous solutions can be treated using Xanthated Tea Waste as a low-cost adsorbent.
Mechanistic Insights into Glycoside 3-Oxidases Involved in C-Glycoside Metabolism in Soil Microorganisms
Authors: Taborda André , Frazão Tomas , Rodrigues Miguel V. , Fernández-Luengo Xavier , Sancho Ferran , Lucas Maria Fátima , Frazão Carlos , Ventura M. Rita , Masgrau Laura , Borges Patrícia T. , Martins Ligia O 
Published: March 2023

Abstract
C-glycosides are natural products with important biological activities but are recalcitrant to degradation. Glycoside 3-oxidases (G3Oxs) are newly identified bacterial flavo-oxidases from the glucose-methanol-coline (GMC) superfamily that catalyze the oxidation of C-glycosides with the concomitant reduction of O2 to H2O2. This oxidation is followed by C-C acid/base-assisted bond cleavage in two-step C-deglycosylation pathways. Soil and gut microorganisms have different oxidative enzymes, but the details of their catalytic mechanisms are largely unknown. Here, we report that PsGO3x oxidizes at 50,000-fold higher specificity (kcat/Km) the glucose moiety of mangiferin to 3-keto-mangiferin than free D-glucose to 2-keto-glucose. Analysis of PsG3Ox X-ray crystal structures and PsGO3x in complex with glucose and mangiferin, combined with mutagenesis and molecular dynamics simulations, revealed distinctive features in the topology surrounding the active site that favors catalytically competent conformational states suitable for recognition, stabilization, and oxidation of the glucose moiety of mangiferin. Furthermore, their distinction to pyranose 2-oxidases (P2Oxs) involved in wood decay and recycling is discussed from an evolutionary, structural, and functional viewpoint.
Privacy-Preserving Federated Learning Framework using Permissioned Blockchain
Authors: Kasyap Harsh , Tripathy Somanath 
Published: March 2023

Abstract
Data is readily available with the growing number of smart and IoT devices. Industries of different sectors follow technological advancement to be benefited from data sharing. However, application-specific data is available in small chunks and distributed across demographics. Additionally, sharing data online brings serious concerns and poses various security and privacy threats. To address these issues, federated learning (FL), a secure and collaborative learning paradigm, would be suitable, which brings the machine learning model to the data owners. Unfortunately, FL is prone to poisoning and inference attacks in presence of malicious users and curious servers. This work proposes a permissioned blockchain based federated learning framework, called PrivateFL (Privacy-Preserving Federated Learning Framework). PrivateFL replaces the central server with a Hyperledger Fabric network, to prevent inference attacks. Further, we propose VPSA (Vertically Partitioned Secure Aggregation) tailored to PrivateFL framework, which performs robust and secure aggregation. PrivateFL facilitates multi-tenancy for learning different machine learning models. Theoretical analysis proves that the system is resistant against inference attacks, even if n-1 peers are compromised. A secure prediction mechanism is also proposed to securely query a global model and protecting its intellectual property rights. Experimental evaluation shows that PrivateFL performs better than the traditional (centralized) learning systems and converges faster, while capable enough to detect malicious updates.
Holistic Bursting Cells Store Long-term Memory in Auditory Cortex
Authors: Li Ruijie , Huang Junjie , Liang Susu , Liang Shanshan , Wang Meng , Liao Xiang , Lyu Jing , Zhou Zhenqiao , Jin Wenjun , Chen Haiyang , Holder Damaris , Liu Hongbang , Zhang Jianxiong , Li Min , Tang Yuguo , Remy Stefan , Pakan Janelle , Chen Xiaowei , Jia Hongbo 
Published: March 2023

Abstract
The sensory neocortex has been since long suggested to be a substrate for long-term memory storage, yet which exact cells store long-term memories remained neither known nor visible over a century. Here, using a combination of day-by-day two-photon Ca2+ imaging and targeted single-cell loose-patch recording in a non-fear auditory associative learning paradigm, we reveal sparsely distributed neurons in layer 2/3 of auditory cortex emerged step-wise from quiescence into bursting mode, which then invariably expressed a holistic information of the learned composite sounds, referred to as holistic bursting (HB) cells. Notably, it was not shuffled populations but the same sparse HB cells that causally embodied the behavioral relevance of the learned composite sounds, pinpointing HB cells as long-term memory storage in the sensory neocortex.
Youth santri communication strategies to reduce uncertainty at the beginning of relationships with the opposite sex
Authors: Nugroho Ihwan Agung , Kusumajanti Kusumajanti , Irawatie Aniek 
Published: March 2023

Communication between the opposite sex among Islamic boarding school students is a separate field in Islamic communication because they are governed by strict rules. This study aims to examine the communication strategies used by adolescents who are in Islamic boarding schools to reduce uncertainty at the beginning of their relationship. This study is interesting because santri are basically teenagers like teenagers in general. This study uses a quasi-qualitative method with a phenomenological approach. The research data was obtained through in-depth interviews conducted directly with six informants. The data is then analyzed by Uncertainty Reduction theory. The results of the research show that interpersonal communication is used as a strategy to reduce uncertainty. Interpersonal communication acts as a bridge of information and a means of confirming the correctness of data obtained by informants about the opposite sex, as well as bonding and enhancing closeness in relationships. This research also reveals that the basic reason for young students wanting to have a relationship is because they are curious and need someone to encourage them. This study contributes to the development of a communication strategy based on pesantren morals. The moral of the pesantren itself is one of the bases of the Islamic communication tradition.***Komunikasi antar lawan jenis dalam kalangan santri pesantren merupakan bidang tersendiri dalam komunikasi Islam karena mereka diatur oleh aturan pesantren yang ketat. Studi ini bertujuan untuk mengkaji strategi komunikasi yang digunakan oleh para remaja yang berada di dalam pondok pesantren guna mengurangi ketidakpastian pada awal hubungan mereka. Kajian ini menarik karena santri pada dasarnya adalah para remaja sebagaimana remaja pada umumnya. Studi ini menggunakan metode quasi-kualitatif dengan pendekatan fenomenologi. Data penelitian ini diperoleh melalui wawancara mendalam yang dilakukan secara langsung kepada enam informan. Data tersebut kemudian dianalisis dengan teori Pengurangan Ketidakpastian. Hasil penelitian menunjukkan bahwa komunikasi antarpribadi digunakan sebagai strategi mengurangi ketidakpastian. Komunikasi antarpribadi berperan sebagai jembatan informasi dan sarana mengkonfirmasi kebenaran data yang diperoleh para informan tentang lawan jenisnya, juga sebagai perekat dan penambah kedekatan dalam hubungan. Studi ini juga mengungkap alasan mendasar santri remaja ingin menjalin hubungan adalah karena rasa ingin tahu dan membutuhkan sosok penyemangat. Kajian ini berkontribusi bagi pengembangan strategi komunikasi yang berbasis pada moral pesantren. Moral pesantren sendiri merupakan salah satu basis tradisi komunikasi Islam.
The Role of Health-Saving Technologies in the Work Practice of the Primary School Teacher
Authors: Semiletova A. N. 
Published: March 2023

The purpose of the study: to study the theory and practice of applying health-saving technologies in the work of a primary school teacher; development of a system of lessons using health-saving technologies. Materials and methods. The following general theoretical and empirical research methods are used: analysis, synthesis, definition, study of scientific and theoretical literature, survey and questionnaire methods, pedagogical diagnostics.Results. At the present stage of development of society, an increasing number of negative phenomena are found in the lives of not only adults, but also children, which is supported not only by high rates of incidence, but also by the prevailing indexes of passivity, sedentary lifestyle that modern children and adolescents lead. The former approaches and strategies in the organization of life activity, which were approved by society in the period of post-industrial society, now reveal their own inconsistency, since a qualitative transition from one type of society to another is taking place in the world space. Accordingly, the content and nature of the conditions for the formation of children’s health in an educational organization also change. The authors of the article describe the results of the study of the role of health-saving technologies in the work of a primary school teacher. The main directions of work on the use of health-saving technologies are presented. Summary of these technologies is given. To determine the effectiveness of health-saving technologies in the practice of a primary school teacher, stating, forming and control experiments were organized. To determine the level of knowledge of students about a healthy lifestyle and its key components, the author’s test “Healthy lifestyle” was used. The research results are presented in the form of tables and diagrams.Conclusion. At present, it is safe to say that it is the teacher who is able to do more for the health of the modern student than the doctor. This does not mean that he should perform the duties of a medical officer. It is just that the teacher should work in such a way that schooling does not harm the health of students.The results of the control experiment proved that health-saving technologies helped to maintain and improve the health of students.
Concurrent UPQC Schemes for the Power Quality Improvement in Solar
Photovoltaic Systems
Authors: Chittala Phani Kumar , Elanchezhian E.B. , Subramani Pragaspathy 
Published: March 2023

Aims:
Aim of this research is to propose a novel concurrent UPQC scheme for improving the power quality issues in grid integrated solar photovoltaic (PV) systems.

Background:
The power quality is a major issue for the grid integration of renewable energy sources. Issues like voltage sag, voltage swell, harmonics & non-linear load variations are certainly observed in the distributed energy system and it is mandated that any system has to depend on advanced controllers to improve power quality and stabilize the electrical parameters. Controller related power quality improvements are a bit easier to design but the tuning of power is difficult in this aspect.

Objective:
In order to overcome the aforesaid limitation, this particular paper proposes a new concurrent UPQC scheme for improving the four different power quality issues in grid integrated solar photovoltaic (PV) system such as voltage sag, voltage swell, non-linear load variations and current harmonics.

Methods:
The operating regions of each power quality issues are examined in the I-V curves of PV specifications and the new operating modes of PV systems are mapped for every quality improvement considering the power, current and frequency of the grid and load as well. The pool of solutions is developed from the real power, reactive power and converter duty cycle and verified with the proposed solutions. Additionally, the designed switching frequency of the proposed system has a 5% variation for practical irradiance. The PV uniform irradiance profile matches the real power for various proposed concurrent UPQC schemes.

Results:
Finally, the simulation results are presented to validate the operation of the proposed concurrent UPQC schemes for PV system. The comparative study of the proposed concurrent UPQC scheme for PV system with appropriate literature is presented. The superiority of the proposed schemes infers studying the odd harmonic components up to 100th order after implementing the proposed concurrent UPQC scheme for PV system.

Conclusion:
From the measured results, it is concluded that a new concurrent optimization scheme enhances the operation of solar PV system that integrates with the grid. The power quality issues like voltage & current swell, voltage & current sag, voltage imbalance, and harmonics are reduced compared to existing methods. The validation of the schemes is achieved through the group constraints and the operating slopes in each region.
LAS STEM COMO ESTRATEGIA PARA FORTALECER LA CIENCIA Y LA TECNOLOGIA
Authors: Salas Álvarez Daniel José , Espitia  Sanjuán Luis Armando 
Published: March 2023

Las STEM (Science, Technology, Engineering and Mathematics) sirven para designar las disciplinas académicas asociadas con la ciencia, tecnología, ingeniería y las matemáticas y se utilizan como base para apoyar el desarrollo de la ciencia, tecnología e innovación desde la educación, especialmente en Estados Unidos, Europa, Asia y Australia. La UNESCO, en un estudio reciente (IBE, Especial Alert STEM education, 2016) ha puesto en el debate internacional su preocupación por la disminución constante de jóvenes en la ciencia y la escasez de ingenieros, en muchas ocasiones por la dificultad que sienten los estudiantes para enfretarse a las matemáticas y las tecnologías.
Estudio de la zeolita beta modificada con Ce, La, -SO3H y óxidos de hierro en la hidrólisis de celulosa
Authors: Chaparro Javier R , Pazos Zarama Mery C. , Martinez José J. , Vargas Annie Y. , Rojas Hugo A. 
Published: March 2023

La acidez de la zeolita beta fue modificada por impregnación con cerio, lantano, grupos sulfónicos y óxidos de hierro, este último se utilizó para generar propiedades magnéticas en el material que permitan la recuperación del catalizador y reciclaje en reacción en fase líquida. Los sólidos obtenidos fueron caracterizados por DRX, espectroscopia infrarroja FT-IR, la acidez fue obtenida por titulación y la actividad catalítica fue evaluada en la hidrólisis de celulosa cristalina como porcentaje de azúcares reductores totales (ART). La cristalinidad de los sólidos impregnados con Óxidos de Ce y La no se ve afectada, caso contrario ocurre cuando se impregna con óxidos de hierro, además la acidez disminuye en ambos casos. La incorporación de grupos sulfónicos tanto a la zeolita beta precursora como a la magnetizada aumenta la acidez y mostró rendimientos del 59% y 38% respectivamente alto rendimiento de azúcares reductores totales en la reacción.
Twitter's Role in Combating the Magnetic Vaccine Conspiracy Theory: Social Network Analysis of Tweets
Authors: Ahmed Wasim , Das Ronnie , Vidal-Alaball Josep , Hardey Mariann , Fuster-Casanovas Aïna 
Published: March 2023

Background
The popularity of the magnetic vaccine conspiracy theory and other conspiracy theories of a similar nature creates challenges to promoting vaccines and disseminating accurate health information.

Objective
Health conspiracy theories are gaining in popularity. This study's objective was to evaluate the Twitter social media network related to the magnetic vaccine conspiracy theory and apply social capital theory to analyze the unique social structures of influential users. As a strategy for web-based public health surveillance, we conducted a social network analysis to identify the important opinion leaders sharing the conspiracy, the key websites, and the narratives.

Methods
A total of 18,706 tweets were retrieved and analyzed by using social network analysis. Data were retrieved from June 1 to June 13, 2021, using the keyword vaccine magnetic. Tweets were retrieved via a dedicated Twitter application programming interface. More specifically, the Academic Track application programming interface was used, and the data were analyzed by using NodeXL Pro (Social Media Research Foundation) and Gephi.

Results
There were a total of 22,762 connections between Twitter users within the data set. This study found that the most influential user within the network consisted of a news account that was reporting on the magnetic vaccine conspiracy. There were also several other users that became influential, such as an epidemiologist, a health economist, and a retired sports athlete who exerted their social capital within the network.

Conclusions
Our study found that influential users were effective broadcasters against the conspiracy, and their reach extended beyond their own networks of Twitter followers. We emphasize the need for trust in influential users with regard to health information, particularly in the context of the widespread social uncertainty resulting from the COVID-19 pandemic, when public sentiment on social media may be unpredictable. This study highlights the potential of influential users to disrupt information flows of conspiracy theories via their unique social capital.
Wait time for outpatients in public hospitals: a survey from North China (Preprint)
Authors: Xu Zhiwei 
Published: March 2023

BACKGROUND

Outpatient department as the first department of hospital to directly contact with patients, is an important department to take medical assistance and service assurance for patients. The wait time is an important index which can reflect the satisfaction of patients and the situation of the utilization of health resources. Our study shows the direct time and indirect time of outpatient in order to find out the value of wait time in hospital management.

OBJECTIVE

By investigating the waiting time of public hospitals, we try to find the current situation of efficiency in public hospitals in China, and provide suggestions for the future reform of China's medical and health system.

METHODS

The data come from nine hospital which was selected by layering in Beijing and Shandong, there are three tertiary hospital, three intermediate hospital and three primary hospital or community hospital. The questionnaire which was designed by expert group included general information and detailed information about wait time in outpatient department. 1159 questionnaires are given out and all questionnaires are collected back, there are 1098 of 1159 can be used effectively, the effective rate was 94.73%. Excel 2003 and SAS are used to analyze the data.

RESULTS

Compared with register group, both the indirect wait time and direct wait time are significant shorter in reservation group. The age and education level impact the using of reservation system. Compared among different level hospitals, the direct wait time and indirect wait time significant shorter in low grade hospital, among the arrival time, the direct wait time and indirect wait time of lower half time period are significant shorter than upper half time period.

CONCLUSIONS

Combine the reservation system and set-convenience register can reduce both the indirect wait time and direct wait time, it also can meet the demand of those patients who older than 65 years or low education.

CLINICALTRIAL

NA
MENTORING CHILDREN TO LEARN AT HOME IN DISTANCE LEARNING DURNG THE COVID-19 PANDEMIC IN TASIKMALAYA CITY
Authors: Karwati Lilis , Hamdan Ahmad 
Published: March 2023

Learning activities during the pandemic are carried out online at home, of course it is the responsibility of the family, especially parents, to accompany the child during home study. Parents should be prepared to accompany and guide their children learning from home. People play a role in accompanying and guiding children during online learning, parents must also understand the applications used during online learning. This research is qualitative phenomenology research, it aims to analyze children's learning assistance during distance learning during the Covid-19 pandemic in Tasikmalaya City. The data collection techniques used in this study are interviews, observations and documentation. The subjects of this study were parents of children who did online learning. The results showed that during the pandemic almost the entire primary school (SD) in Tasikmalaya city learning was conducted online. Learning carried out online has several problems, namely the limitations of teachers in delivering materials that make the child do not understand the material in its entirety, parents should increase the cost of spending on internet costs during online learning. Learning at home accompanied by parents makes the child closer to the parents, the child feels safe and comfortable being close to the parents so that the child becomes more confident.