bluuebunny/crossref_metadata_2025_split huggingface dataset:
Implementing Enhanced Perioperative Care in Emergency General Surgery: A Prospective Multicenter Observational Study
Authors: Ceresoli Marco , Biloslavo Alan , Bisagni Pietro , Ciuffa Carlo , Fortuna Laura , La Greca Antonio , Tartaglia Dario , Zago Mauro , Ficari Ferdinando , Foti Giuseppe , Braga Marco ,   the ERAS‐emergency surgery collaborative group, Armao Francesca Teodora , Bottari Andrea , Ballabio Michele , Beretta Luigi , Bondi Chiara , Calcinati Serena , Carlucci Michele , Chiarugi Massimo , Ciravegna Arianna Libera , Coccolini Federico , Cozza Valerio , Cremonini Camilla , Ferraina Federica , Fico Valeria , Fogliata Michele , Germani Paola , Gianotti Luca , Grandi Samuele , Guiotto Lorenzo , Lena Enrico , Longhi Marco , Lorenzi Irene , Malagnino Alessia , Montino Marco , Paiano Lucia , Pesenti Giovanni , Riccadonna Sara , Romanò Bruno , Russo Andrea , Somigli Riccardo , Tomajer Valentina , Tripodi Vincenzo 
Published: April 2023

AbstractIntroductionERAS pathway has been proposed as the standard of care in elective abdominal surgery. Guidelines on ERAS in emergency surgery have been recently published; however, few evidences are still available in the literature. The aim of this study was to evaluate the feasibility of an enhanced recovery protocol in a large cohort of patients undergoing emergency surgery and to identify possible factors impacting postoperative protocol compliance.MethodsThis is a prospective multicenter observational study including patients who underwent major emergency general surgery for either intra‐abdominal infection or intestinal obstruction. The primary endpoint of the study is the adherence to ERAS postoperative protocol. Secondary endpoints are 30‐day mortality and morbidity rates, and length of hospital stay.ResultsA total of 589 patients were enrolled in the study, 256 (43.5%) of them underwent intestinal resection with anastomosis. Major complications occurred in 92 (15.6%) patients and 30‐day mortality was 6.3%. Median adherence occurred on postoperative day (POD) 1 for naso‐gastric tube removal, on POD 2 for mobilization and urinary catheter removal, and on POD 3 for oral intake and i.v. fluid suspension. Laparoscopy was significantly associated with adherence to postoperative protocol, whereas operative fluid infusion > 12 mL/Kg/h, preoperative hyperglycemia, presence of a drain, duration of surgery and major complications showed a negative association.ConclusionsThe present study supports that an enhanced recovery protocol in emergency surgery is feasible and safe. Laparoscopy was associated with an earlier recovery, whereas preoperative hyperglycemia, fluid overload, and abdominal drain were associated with a delayed recovery.
Elevated Interleukin-37 Associated with Dengue Viral Load in Patients with Dengue Fever
Authors: Zhang Jun-Ai , Wang Jia-Jun , Zhang Wen-Ting , Zhang Li , Zheng Bi-Ying , Liu Gan-Bin , Liang Jing , Lu Yuan-Bin , Wu Xian-Jin , Yao Shu-Ying , Chen Guo-Ying , Xie Yun-Qi , Wu Jun-Yi , Shi Jia-Hua , Pi Jiang , Li Si-Ping , Xu Jun-Fa 
Published: April 2023

AbstractDengue remains a public health issue worldwide. Similar to chronic infectious diseases, stimulation of cytokine production is not enough to drive immune effector cells for effective virus clearance. One possible mechanism is the virus induces a large number of negative stimulatory cytokines inhibiting immune response. Interleukin 37 (IL-37) plays a crucial regulatory role in infection and immunity, inhibits innate and adaptive immunity as an anti-inflammatory cytokine by inhibiting proinflammatory mediators and pathways. To date, there are few studies reporting correlations between dengue fever (DF) and IL-37. In this study we found that the serum IL-37b and IL-37b-producing monocytes in patients were significantly increased in DF patients. A majority of the IL-37b produced by DF patients was produced by monocytes, not lymphocytes. Increased levels of IL-6, IL-10, and IFN-α were also found in DF patients. However, we failed to detect IL-1β, IL-17A and TNF-α in plasma, because of off-target. In our study, there was no relation between IL-6, IL-10, and IFN-α expressions and IL-37b in serum (P > 0.05). The IL-37b-producing monocytes were negatively correlated with the level of IFN-α in serum and platelet count, and positively correlated with lymphocytes percentage (P < 0.05, respectively). Additionally, serum DENV nonstructural protein 1 levels were positively correlated with monocytes percentages (P < 0.05). Our data represents findings for IL-37b expression and its potential mechanisms in DF patients’ immune response.
Application of nanotags and nanobodies for live cell single-molecule imaging of the Z-ring in Escherichia coli
Authors: Westlund Emma , Bergenstråle Axel , Pokhrel Alaska , Chan Helena , Skoglund Ulf , Daley Daniel O. , Söderström Bill 
Published: April 2023

AbstractUnderstanding where proteins are localized in a bacterial cell is essential for understanding their function and regulation. This is particularly important for proteins that are involved in cell division, which localize at the division septum and assemble into highly regulated complexes. Current knowledge of these complexes has been greatly facilitated by super-resolution imaging using fluorescent protein fusions. Herein, we demonstrate with FtsZ that single-molecule PALM images can be obtained in-vivo using a genetically fused nanotag (ALFA), and a corresponding nanobody fused to mEos3.2. The methodology presented is applicable to other bacterial proteins.
Preoperative fibrinogen/CRP score predicts survival in upper urothelial tract carcinoma patients undergoing radical curative surgery
Authors: Egger Valentina , Hutterer Georg C. , Mischinger Johannes , Seles Maximilian , Pichler Renate , Mannweiler Sebastian , Huber Katharina , Balihodzic Amar , Spiegelberg Jasmin , Bauernhofer Thomas , Ahyai Sascha , Zigeuner Richard , Pichler Martin , Barth Dominik A. 
Published: April 2023

Abstract
Purpose
Upper tract urothelial carcinoma (UTUC) represents an often aggressive malignancy associated with poor prognosis. Therefore, finding reliable prognostic biomarkers in patients undergoing curative surgery for improved risk stratification is crucial. We evaluated the prognostic value of the Fibrinogen/C-reactive protein (FC)-score in a cohort of surgically treated UTUC patients.

Methods
170 patients with radiologically and histologically verified UTUC who underwent radical curative surgery between 1990 and 2020, were included. The FC-score was calculated for each patient, with patients receiving 1 point each if Fibrinogen and/or CRP levels were elevated above the 25th or 75th percentile, respectively. Patients were divided into three subgroups according to their FC-score of 0, 1 or 2 point(s). Kaplan–Meier analysis, uni- and multivariable Cox proportional hazard models were implemented. We determined cancer-specific survival (CSS) as primary endpoint, whereas overall survival (OS) and recurrence-free survival (RFS) were considered secondary endpoints.

Results
High FC-score (2 points) was significantly associated with adverse histological features such as vascular invasion (OR = 4.08, 95%CI 1.18–14.15, p = .0027) and tumour necrosis (OR = 6.67, 95%CI 1.35–32.96, p = 0.020). Both, uni- and multivariable Cox proportional hazard models showed the FC-score as a significant predictor for CSS (univariable analysis: FC-score = 1: HR = 1.90, 95%CI 0.92–3.93, p = 0.085 | FC-score = 2: HR = 2.86, 95%CI 1.22–6.72, p = 0.016). Furthermore, in univariable analysis, patients with higher FC-score had significantly shorter OS (FC-score = 1: HR = 1.32, 95%CI 0.70–2.49, p = 0.387 | FC-score = 2: HR = 2.19, 95%CI 1.02–4.67, p = 0.043). However, this did not prevail in multivariable analysis.

Conclusion
The FC-score represents a novel potential biomarker in patients with UTUC undergoing radical curative surgery.
A unifying framework for rank and pseudo-rank based inference using nonparametric confidence distributions
Authors: Beck Jonas , Bathke Arne C. 
Published: April 2023

AbstractNonparametric confidence distributions estimate statistical functionals by a distribution function on the parameter space, instead of the classical point or interval estimators. The concept bears analogy to the Bayesian posterior, but is nevertheless a completely frequentist concept. In order to ensure the desired statistical properties, we require that the cumulative distribution function on the parameter space is, evaluated at the true parameter, uniformly distributed over the unit interval. Our main focus lies on developing confidence distributions for the nonparametric relative effect and some natural extensions thereof. We develop asymptotic, range preserving and—especially important in the case of small sample sizes—approximate confidence distributions based on rank and pseudo-rank procedures. Due to the close relationship between point estimators, confidence intervals and p-values, these can all be approached in a unified manner within the framework of confidence distributions. The main goal of our contribution is to make the powerful theory of confidence distributions available in a nonparametric context, that is, for situations where methods relying on parametric assumptions are not justifiable. Application of the proposed methods and interpretation of the results is demonstrated using real data sets, including ordinal, non-metric data.
Outcome of different reconstruction options using allografts in revision total hip arthroplasty for severe acetabular bone loss: a systematic review and meta-analysis
Authors: Strahl André , Boese Christoph Kolja , Ries Christian , Hubert Jan , Beil Frank Timo , Rolvien Tim 
Published: April 2023

Abstract
Introduction
Several studies have reported good to excellent outcomes of revision total hip arthroplasty (rTHA) using allografts for treating severe acetabular bone defects. However, precise information on the impact of allograft type and reconstruction method is not available.

Material and methods
Systematic literature search was performed in Medline and Web of Science including patients with acetabular bone loss classified according to the Paprosky classification who underwent rTHA involving the use of allografts. Studies with a minimum follow-up of 2 years published between 1990 and 2021 were included. Kendall correlation was applied to determine the relationship between Paprosky grade and allograft type use. Proportion meta-analyses with 95% confidence interval (CI) were performed to summarize the success of various reconstruction options, including allograft type, fixation method, and reconstruction system.

Results
Twenty-seven studies met the inclusion criteria encompassing 1561 cases from 1491 patients with an average age of 64 years (range 22–95). The average follow-up period was 7.9 years (range 2–22). Structural bulk and morselized grafts were used in equal proportions for all Paprosky acetabular defect types. Their use increased significantly with the type of acetabular defect (r = 0.69, p = 0.049). The overall success rate ranged from 61.3 to 98.3% with a random effect pooled estimate of 90% [95% CI 87–93]. Trabecular metal augments (93% [76–98]) and shells (97% [84–99]) provided the highest success rates. However, no significant differences between reconstruction systems, allograft types and fixation methods were observed (p > 0.05 for all comparisons).

Conclusion
Our findings highlight the use of bulk or morselized allograft for massive bone loss independent of Paprosky classification type and indicate similar good mid- to long-term outcomes of the different acetabular reconstruction options using allografts.

Clinical trial registration
PROSPERO: CRD42020223093.
Update on the diagnosis and treatment of neuromyelits optica spectrum disorders (NMOSD) – revised recommendations of the Neuromyelitis Optica Study Group (NEMOS). Part I: Diagnosis and differential diagnosis
Authors: Jarius Sven , Aktas Orhan , Ayzenberg Ilya , Bellmann-Strobl Judith , Berthele Achim , Giglhuber Katrin , Häußler Vivien , Havla Joachim , Hellwig Kerstin , Hümmert Martin W. , Kleiter Ingo , Klotz Luisa , Krumbholz Markus , Kümpfel Tania , Paul Friedemann , Ringelstein Marius , Ruprecht Klemens , Senel Makbule , Stellmann Jan-Patrick , Bergh Florian Then , Tumani Hayrettin , Wildemann Brigitte , Trebst Corinna ,   Neuromyelitis Optica Study Group (NEMOS)
Published: April 2023

AbstractThe term ‘neuromyelitis optica spectrum disorders’ (NMOSD) is used as an umbrella term that refers to aquaporin-4 immunoglobulin G (AQP4-IgG)-positive neuromyelitis optica (NMO) and itsformes frustesand to a number of closely related clinical syndromes without AQP4-IgG. NMOSD were originally considered subvariants of multiple sclerosis (MS) but are now widely recognized as disorders in their own right that are distinct from MS with regard to immunopathogenesis, clinical presentation, optimum treatment, and prognosis. In part 1 of this two-part article series, which ties in with our 2014 recommendations, the neuromyelitis optica study group (NEMOS) gives updated recommendations on the diagnosis and differential diagnosis of NMOSD. A key focus is on differentiating NMOSD from MS and from myelin oligodendrocyte glycoprotein antibody-associated encephalomyelitis (MOG-EM; also termed MOG antibody-associated disease, MOGAD), which shares significant similarity with NMOSD with regard to clinical and, partly, radiological presentation, but is a pathogenetically distinct disease. In part 2, we provide updated recommendations on the treatment of NMOSD, covering all newly approved drugs as well as established treatment options.
Validating models of sensory conflict and perception for motion sickness prediction
Authors: Irmak Tugrul , Pool Daan M. , de Winkel Ksander N. , Happee Riender 
Published: April 2023

AbstractThe human motion perception system has long been linked to motion sickness through state estimation conflict terms. However, to date, the extent to which available perception models are able to predict motion sickness, or which of the employed perceptual mechanisms are of most relevance to sickness prediction, has not been studied. In this study, the subjective vertical model, the multi-sensory observer model and the probabilistic particle filter model were all validated for their ability to predict motion perception and sickness, across a large set of motion paradigms of varying complexity from literature. It was found that even though the models provided a good match for the perception paradigms studied, they could not be made to capture the full range of motion sickness observations. The resolution of the gravito-inertial ambiguity has been identified to require further attention, as key model parameters selected to match perception data did not optimally match motion sickness data. Two additional mechanisms that may enable better future predictive models of sickness have, however, been identified. Firstly, active estimation of the magnitude of gravity appears to be instrumental for predicting motion sickness induced by vertical accelerations. Secondly, the model analysis showed that the influence of the semicircular canals on the somatogravic effect may explain the differences in the dynamics observed for motion sickness induced by vertical and horizontal plane accelerations.
The effectiveness of endoscopic ultrasonography findings to distinguish benign and malignant intraductal papillary mucinous neoplasm
Authors: Dong Wu , Zhen Ding , Xiaoyan Wang , Bin Cheng , Ruifeng Wang , Shanyu Qin , Zhuoran Li , Kai Song , Wenming Wu , Aiming Yang , Xi Wu 
Published: April 2023

Abstract
Background and aims
Accurate evaluation of intraductal papillary mucinous neoplasm (IPMN) is necessary to inform clinical decision-making. But it is still difficult to distinguish benign and malignant IPMN preoperatively. This study aims to evaluate the utility of EUS to predict the pathology of IPMN.

Methods
Patients with IPMN who underwent endoscopic ultrasound within 3 months before surgery were collected from six centers. Logistic regression model and random forest model were used to determine risk factors associated with malignant IPMN. In both models, 70% and 30% of patients were randomly assigned to the exploratory group and validation group, respectively. Sensitivity, specificity, and ROC were used in model assessment.

Results
Of the 115 patients, 56 (48.7%) had low-grade dysplasia (LGD), 25 (21.7%) had high-grade dysplasia (HGD), and 34 (29.6%) had invasive cancer (IC). Smoking history (OR = 6.95, 95%CI: 1.98–24.44, p = 0.002), lymphadenopathy (OR = 7.91, 95%CI: 1.60–39.07, p = 0.011), MPD > 7 mm (OR = 4.75, 95%CI: 1.56–14.47, p = 0.006) and mural nodules > 5 mm (OR = 8.79, 95%CI: 2.40–32.24, p = 0.001) were independent risk factors predicting malignant IPMN according to the logistic regression model. The sensitivity, specificity, and AUC were 0.895, 0.571, and 0.795 in the validation group. In the random forest model, the sensitivity, specificity, and AUC were 0.722, 0.823, and 0.773, respectively. In patients with mural nodules, random forest model could reach a sensitivity of 0.905 and a specificity of 0.900.

Conclusions
Using random forest model based on EUS data is effective to differentiate benign and malignant IPMN in this cohort, especially in patients with mural nodules.
An enhanced efficient optimization algorithm (EINFO) for accurate extraction of proton exchange membrane fuel cell parameters
Authors: Singla Manish Kumar , Hassan Mohamed H. , Gupta Jyoti , Jurado Francisco , Nijhawan Parag , Kamel Salah 
Published: April 2023

AbstractIn order to assure accurate modelling, this study presents a new technique for appropriately modelling and simulating a proton exchange membrane fuel cell (PEMFC) system. The PEMFC is a cleaner and more sustainable energy source as compared to fossil fuels. The fundamental idea is to minimize the sum of squared error (SSE) between the estimated and measured output voltage for the Ballard Mark V model in order to identify the model parameters of PEMFC stacks as efficiently as possible using a newly developed meta-heuristic called enhanced efficient optimization algorithm (EINFO). The proposed optimizer is considered an enhanced version of the original INFO algorithm. By balancing the exploration and exploitation phases better, the EINFO algorithm is intended to improve the performance of the original INFO approach and prevent local optima. The new method was tested on 23 benchmark functions and compared to the original INFO algorithm as well as other recently evolved optimizers. The algorithm is examined and compared with some literature meta-heuristics, including the particle swarm optimization, sine cosine algorithm, dragonfly algorithm, atom search optimization, Harris hawks optimization, and efficient optimization algorithm, using 50 independent runs, in terms of convergence speed and least SSE. When compared to other methods, the final findings show that, the suggested technique achieves the fastest convergence speed.
Heat generated during dental treatments affecting intrapulpal temperature: a review
Authors: Lau Xin Er , Liu Xiaoyun , Chua Helene , Wang Wendy Jingwen , Dias Maykon , Choi Joanne Jung Eun 
Published: April 2023

Abstract
Introduction
Heat is generated and transferred to the dentine-pulp complex during various dental procedures, such as from friction during cavity preparations, exothermic reactions during the polymerisation of restorative materials and when polishing restorations. For in vitro studies, detrimental effects are possible when intra-pulpal temperature increases by more than 5.5°C (that is, the intra-pulpal temperature exceeds 42.4°C). This excessive heat transfer results in inflammation and necrosis of the pulp. Despite numerous studies stating the importance of heat transfer and control during dental procedures, there are limited studies that have quantified the significance. Past studies incorporated an experimental setup where a thermocouple is placed inside the pulp of an extracted human tooth and connected to an electronic digital thermometer.

Methods
This review identified the opportunity for future research and develop both the understanding of various influencing factors on heat generation and the different sensor systems to measure the intrapulpal temperature.

Conclusion
Various steps of dental restorative procedures have the potential to generate considerable amounts of heat which can permanently damage the pulp, leading to pulp necrosis, discoloration of the tooth and eventually tooth loss. Thus, measures should be undertaken to limit pulp irritation and injury during procedures. This review highlighted the gap for future research and a need for an experimental setup which can simulate pulp blood flow, temperature, intraoral temperature and intraoral humidity to accurately simulate the intraoral conditions and record temperature changes during various dental procedures.
The longitudinal relationship between dissociative symptoms and self-harm in adolescents: a population-based cohort study
Authors: Tanaka Riki , Ando Shuntaro , Kiyono Tomoki , Minami Rin , Endo Kaori , Miyashita Mitsuhiro , Yamasaki Syudo , Kanata Sho , Fujikawa Shinya , Hiraiwa-Hasegawa Mariko , Nishida Atsushi , Kasai Kiyoto 
Published: April 2023

AbstractPrevious studies have reported that dissociative symptoms (DIS) are associated with self-harm (SH) in adolescents. However, most of these studies were cross-sectional, which limits the understanding of their theoretical relationship. We aimed to investigate the longitudinal relationship between DIS and SH in the general adolescent population. We used data from the Tokyo Teen Cohort study (N = 3007). DIS and SH were assessed at times 1 and 2 (T1 and T2) (12 years of age and 14 years of age, respectively). DIS were assessed using the parent-report Child Behavior Checklist (CBCL), and severe dissociative symptoms (SDIS) were defined as a score above the top 10th percentile. The experience of SH within 1 year was assessed by a self-report questionnaire. The longitudinal relationship between DIS and SH was examined using regression analyses. Using logistic regression analyses, we further investigated the risk for SH at T2 due to persistent SDIS and vice versa. DIS at T1 tended to predict SH at T2 (odds ratio (OR) 1.11, 95% CI 0.99 to 1.25, p = 0.08), while SH at T1 did not predict DIS at T2 (B = − 0.03, 95% CI − 0.26 to 0.20, p = 0.81). Compared with adolescents without SDIS, those with persistent SDIS had an increased risk of SH at T2 (OR 2.61, 95% CI 1.28 to 5.33, p = 0.01). DIS tended to predict future SH, but SH did not predict future DIS. DIS may be a target to prevent SH in adolescents. Intensive attention should be given to adolescents with SDIS due to their increased risk of SH.