bluuebunny/crossref_metadata_2025_split huggingface dataset:
Idiopathic pulmonary hemosiderosis as an occupational disease: a clinical case
Authors: Raznatovska О.М. , Gumeniuk G.L. , Yasinskyi R.M. , Fedorec A.V. 
Published: June 2023

BACKGROUND. Idiopathic pulmonary hemosiderosis (IPH) in adults is a rare pathology of unknown etiology. We did not find information about IPH in adults with occupational hazards in the available literary sources, which makes this work relevant.
OBJECTIVE. To analyze the peculiarities of the IPH course in a patient with 23 years’ experience as a gas-electric welder at factories by our own clinical observation.
RESULTS AND DISCUSSION. Changes in the form of heterogeneous pneumatization of the lung parenchyma due to the increased interstitial component were determined on the computer tomography of the chest cavity (CT of the chest cavity) 1.5 years before the patient’s visit, but no additional examination was prescribed, and only the diagnosis “Chronic obstructive pulmonary disease” (COPD) was made. Negative dynamics due to the increase of miliary nodular dissemination of the lungs was revealed on the CT scan of the chest after 1.5 years. IPH was already detected pathohistologically after videothoracoscopy of the right lung with biopsy. Shortness of breath and cough increased in the patient, but apart from treatment aimed at COPD treating, no other therapy was prescribed (this therapy did not have a positive effect). The patient underwent a comprehensive immunological examination: the indicators of the anti-neutrophil cytoplasmic antibodies (ANCA) profile and the complex immunological blood test were within the normal range, which ruled out pulmonary vasculitis and an immune-mediated process. Considering the positive Quantiferon test, the patient was examined and the tuberculosis was excluded. Patient have not been suffered from hemoptysis and anemia from the moment of detection of the first changes on the CT scan of chest up to the present time. Due to treatment, the clinical and radiological stabilization of the process was determined after 4 months: the clinical symptoms of the disease decreased; small nodular shadows with areas of fibrosis, which are characteristic of the period of remission, were determined on the CT scan of the chest.
CONCLUSIONS. IPH course features in a patient with a professional route are: a long period of development with COPD manifestations (without effect of therapy), absence of hemoptysis and anemia, normal indicators of the ANCA profile and complex immunological examination, a positive Quantiferon test. Corticosteroid therapy in high doses has a positive effect, which is manifested in the clinical and radiological stabilization of the process. The mechanism of IPH development may have been a toxic mechanism (23 years of work experience as a gas-electric welder at factories). Timely detection of IPH and timely prescribed corticosteroid therapy will prevent the progression of the process and the development of complications, as well as reduce mortality from this disease. Patients with IPH should be under dynamic observation due to timely evaluation of CT-dynamics of the process in the lungs and correction of the dose of corticosteroids.
The role of invasive methods in errors in the differential diagnosis of tuberculosis of the lungs and pleura: clinical examples
Authors: Opanasenko M.S. , Tereshkovych O.V. , Lysenko V.I. , Levanda L.I. , Shamrai M.Yu. , Shestakova O.D. 
Published: June 2023

BACKGROUND. Differential diagnosis between non-specific diseases of the lungs and pleura and tuberculosis (TB) of these organs is an urgent problem. According to a number of authors, the frequency of false diagnosis of TB is 34-40 %. Difficulties in the differential diagnosis of pulmonary TB (pleura) and non-specific diseases of the lungs and pleura arise in most cases with exudative and caseous inflammation of the lung tissue. The use of various types of surgical interventions, both diagnostic and therapeutic, provides a greater range of conducting various laboratory tests, especially when this issue may be related to the differential diagnosis of TB. Thus, during surgical intervention, it is possible to obtain biopsy material, which can be sent for pathological, molecular genetic and bacteriological research.
MATERIALS AND METHODS. Two clinical cases are presented, in which, due to suspicion of specific inflammation in the lungs and pleura, we used all the above-mentioned methods of laboratory diagnosis of resection biopsy material during surgical interventions.
CONCLUSIONS. This approach provides objective morphological and biological detection of Mycobacterium tuberculosis, and also makes it possible to determine the sensitivity to 1st and 2nd line antituberculosis drugs, which ultimately helps to establish the correct diagnosis and prescribe an effective treatment scheme.
EXPERTS II - How are patient and caregiver participation in health and social care shaped by experienced burden of treatment and social inequalities? Protocol for a qualitative synthesis.
Authors: May Carl R , Chew-Graham Carolyn A , Gallacher Katie I , Gravenhorst Katja C , Mair Frances S , Nolte Ellen , Richardson Alison 
Published: June 2023

Background: The workload health and social care service users and caregivers take on, and their capacity to do this work is important. It may play a key part in shaping the implementation of innovations in health service delivery and organisation; the utilisation and satisfaction with services; and the outcomes of care. Previous research has often focused on experiences of a narrow range of long-term conditions, and on factors that shape adherence to self-care regimes. Aims: With the aim of deriving policy and practice implications for service redesign, this evidence synthesis will extend our understanding of service user and caregiver workload and capacity by comparing how they are revealed in qualitative studies of lived experience of three kinds of illness trajectories: long-term conditions associated with significant disability (Parkinson’s disease, schizophrenia); serious relapsing remitting disease (Inflammatory Bowel Disease, bipolar disorder); and rapidly progressing acute disease (brain cancer, early onset dementia). Methods: We will review and synthesise qualitative studies of lived experience of participation in health and social care that are shaped by interactions between experienced treatment burdens, social inequalities and illness trajectories. The review will involve: Construction of a theory-informed coding manual; systematic search of bibliographic databases to identify, screen and quality assess full-text papers. Analysis of papers using manual coding techniques, and text mining software; construction of taxonomies of service user and caregiver work and capacity. Designing a model of core components and identifying common factors across conditions, trajectories, and contexts. Work with practitioners, and a Patient and Public Involvement (PPI) group, to explore the validity of the models produced; to develop workload reduction strategies; and to consider person-centred service design. Dissemination: We will promote workload reduction models to support service users and caregivers and produce policy briefs and peer-reviewed publications for practitioners, policy-makers, and researchers.
IVF Children Acquiring Emirati Citizenship by the Nationality of a Parent (Jus Sanguinis)
Authors: Enizi Ziad Al , Mahameed Waleed Fouad 
Published: June 2023

Objective. The technology of in vitro fertilization (IVF) opened a new era in the treatment of infertility but at the same time it created new challenges for civil and international private law. This concerns the issues of determining and/or acquiring child citizenship and legal conflicts associated with this.
Materials and methods. This study examines the aspects of obtaining UAE citizenship through the study of the UAE Citizenship Law and the principle of jus sanguinis (right of blood) when citizenship is acquired by a parent’s nationality. The research aims to identify whether the current legislative regulation of the UAE meets the current challenges in the field of family relations against the backdrop of new medical advances in IVF. The paper considers the aspects of the UAE legal regulation in the scope of family law relationships. The above issues were considered from the critical evaluation prospects taking into account the potential ways for their improvement.
Results and Discussion. The problems associated with determining the citizenship for those born as a result of IVF are the subject of discussion, while, as practice shows, the law often does not keep pace with the development of reproductive technologies. Based on the analysis of legal regulation and practice, the study summarizes the grounds for obtaining UAE citizenship by children conceived through IVF and refusals to obtain it.
Conclusion. The paper recommends mitigating the requirement of proof of paternity as a condition to grant the nationality to an IVF child, especially in the case of purely medical errors in which father has no responsibility.
Bangladesh Journal of Medical Science Vol. 22 No. 03 July’23 Page : 676-686
Prognostic Role of CD68+ and CD163+ Tumour-Associated Macrophages and PD-L1 Expression in Oral Squamous Cell Carcinoma: A Meta-Analysis
Authors: Chohan Mohammed Haseeb , Perry Matthew , Laurance-Young Paul , Salih Vehid M. , Foey Andrew D. 
Published: June 2023

Background: Oral squamous cell carcinoma (OSCC) is a common malignant cancer in humans. An abundance of tumour associated macrophages (TAMs) create an immunosuppressive tumour microenvironment (TME). TAM markers (CD163 and CD68) are seen to serve as prognostic factors in OSCC. PD-L1 has seen to widely modulate the TME but its prognostic significance remains controversial. The aim of this meta-analysis is to evaluate the prognostic role of CD163+, CD68+ TAMs and PD-L1 in OSCC patients.Methods: Searches in PubMed, Scopus and Web of Science were performed; 12 studies were included in this meta-analysis. Quality assessment of included studies was performed according to REMARK guidelines. Risk of bias across studies was investigated according to the rate of heterogeneity. Meta-analysis was performed to investigate the association of all three biomarkers with overall survival (OS).Results: High expression of CD163+ TAMs were associated with poor overall survival (HR = 2.64; 95% Cl: [1.65, 4.23]; p &lt; 0.0001). Additionally, high stromal expression of CD163+ TAMs correlated with poor overall survival (HR = 3.56; 95% Cl: [2.33, 5.44]; p &lt; 0.00001). Conversely, high CD68 and PD-L1 expression was not associated with overall survival (HR = 1.26; 95% Cl: [0.76, 2.07]; p = 0.37) (HR = 0.64; 95% Cl: [0.35, 1.18]; p = 0.15).Conclusion: In conclusion, our findings indicate CD163+ can provide prognostic utility in OSCC. However, our data suggests CD68+ TAMs were not associated with any prognostic relevance in OSCC patients, whereas PD-L1 expression may prove to be a differential prognostic marker dependent on tumour location and stage of progression.
A comparative recognition research on excretory organism in medical applications using artificial neural networks
Authors: Selvarajan Shitharth , Manoharan Hariprasath , Iwendi Celestine , Alsowail Rakan A. , Pandiaraj Saravanan 
Published: June 2023

Purpose: In the contemporary era, a significant number of individuals encounter various health issues, including digestive system ailments, even during their advanced years. The major purpose of this study is based on certain observations that are made in internal digestive systems in order to prevent severe cause that usually occurs in elderly people.Approach: To solve the purpose of the proposed method the proposed system is introduced with advanced features and parametric monitoring system that are based on wireless sensor setups. The parametric monitoring system is integrated with neural network where certain control actions are taken to prevent gastrointestinal activities at reduced data loss.Results: The outcome of the combined process is examined based on four different cases that is designed based on analytical model where control parameters and weight establishments are also determined. As the internal digestive system is monitored the data loss that is present with wireless sensor network must be reduced and proposed approach prevents such data loss with an optimized value of 1.39%.Conclusion: Parametric cases were conducted to evaluate the efficacy of neural networks. The findings indicate a significantly higher effectiveness rate of approximately 68% when compared to the control cases.
Zero fluoroscopy catheter ablation for atrial fibrillation: a systematic review and meta-analysis
Authors: Debreceni Dorottya , Janosi Kristof , Bocz Botond , Turcsan Marton , Lukacs Reka , Simor Tamas , Antolič Bor , Vamos Mate , Komocsi Andras , Kupo Peter 
Published: June 2023

IntroductionCatheter ablation for atrial fibrillation (AF) is the most frequently performed cardiac ablation procedure worldwide. The majority of ablations can now be performed safely with minimal radiation exposure or even without the use of fluoroscopy, thanks to advances in 3-dimensional electroanatomical mapping systems and/or intracardiac echocardiography. The aim of this study was to conduct a meta-analysis to compare the effectiveness of zero fluoroscopy (ZF) versus non-zero fluoroscopy (NZF) strategies for AF ablation procedures.MethodsElectronic databases were searched and systematically reviewed for studies comparing procedural parameters and outcomes of ZF vs. NZF approaches in patients undergoing catheter ablation for AF. We used a random-effects model to derive the mean difference (MD) and risk ratios (RR) with a 95% confidence interval (CI).ResultsOur meta-analysis included seven studies comprising 1,593 patients. The ZF approach was found to be feasible in 95.1% of patients. Compared to the NZF approach, the ZF approach significantly reduced procedure time [mean difference (MD): −9.11 min (95% CI: −12.93 to −5.30 min; p &lt; 0.01)], fluoroscopy time [MD: −5.21 min (95% CI: −5.51 to −4.91 min; p &lt; 0.01)], and fluoroscopy dose [MD: −3.96 mGy (95% CI: −4.27 to −3.64; p &lt; 0.01)]. However, there was no significant difference between the two groups in terms of total ablation time [MD: −104.26 s (95% CI: −183.37 to −25.14; p = 0.12)]. Furthermore, there was no significant difference in the acute [risk ratio (RR): 1.01, 95% CI: 1.00–1.02; p = 0.72] and long-term success rates (RR: 0.96, 95% CI: 0.90–1.03; p = 0.56) between the ZF and NZF methods. The complication rate was 2.76% in the entire study population and did not differ between the groups (RR: 0.94, 95% CI: 0.41–2.15; p = 0.89).ConclusionThe ZF approach is a feasible method for AF ablation procedures. It significantly reduces procedure time and radiation exposure without compromising the acute and long-term success rates or complication rates.
Safe and sound: examining the effect of a training targeting psychological safety and trust in peer assessment
Authors: Senden Morgane , De Jaeger Dominique , Coertjens Liesje 
Published: June 2023

IntroductionPeer feedback can be very beneficial for student learning in higher education, yet students may feel uncomfortable providing and receiving peer feedback: they may for example not feel safe in the group or have little trust in their peers’ abilities to provide feedback. Surprisingly, only few studies have investigated how students’ feelings of discomfort can be reduced. To fill this gap, we created a 1-h training session using active learning methods. The training focuses on enhancing students’ perceptions of psychological safety, trust in their abilities and in their peers’ abilities to provide feedback.MethodsThe efficacy of this training was tested using a quasi-experiment with pre-and post-test design. Third-year bachelor students in physical education participated in a peer feedback activity to fulfill the requirement of an obligatory course. In 2019–2020, 47 students participated in a peer assessment activity without specific training on psychological safety and trust (control group), while in 2021–2022, 42 students received specific training before peer assessment (experimental group).ResultsAnalyses include a comparison of the control and experimental groups with regard to (1) the evolution of their perceptions (psychological safety, trust in their abilities, and trust in their peers’ abilities) for pre-to post-test, (2) the quality of the feedback they provided to their peers (3) and the improvement of students’ work between the draft submitted for the peer activity and the final version submitted to the professor.DiscussionResults do not support the training’s efficacy, yet suggest pathways for future research.
Mitochondria-associated regulation in adipose tissues and potential reagents for obesity intervention
Authors: Zheng Yali , Yang Ni , Pang Yueshan , Gong Yanju , Yang Hong , Ding Weijun , Yang Hongya 
Published: June 2023

IntroductionA systematic review analysis was used to assess the profile of mitochondrial involvement in adipose tissue regulation and potential reagents to intervene in obesity through the mitochondrial pathway.MethodsThree databases, PubMed, Web of Science, and Embase, were searched online for literature associated with mitochondria, obesity, white adipose tissue, and brown adipose tissue published from the time of their creation until June 22, 2022, and each paper was screened.Results568 papers were identified, of which 134 papers met the initial selection criteria, 76 were selected after full-text review, and 6 were identified after additional searches. A full-text review of the included 82 papers was performed.ConclusionMitochondria play a key role in adipose tissue metabolism and energy homeostasis, including as potential therapeutic agents for obesity.
Comparison of the neonatal outcomes of progestin-primed ovarian stimulation and flexible GnRH antagonist protocols: a propensity score–matched cohort study
Authors: Du Mingze , Zhang Junwei , Ren Bingnan , Guan Yichun 
Published: June 2023

ObjectiveTo compare the neonatal outcomes of progestin-primed ovarian stimulation (PPOS) and flexible gonadotropin-releasing hormone (GnRH) antagonist protocols.MethodsThis was a retrospective propensity score–matched (PSM) cohort study. Women who underwent their first frozen embryo transfer (FET) cycle with freezing of all embryos followed by PPOS or GnRH antagonist protocols between January 2016 and January 2022 were included. Patients using PPOS were matched with the patients using GnRH antagonist at a 1:1 ratio. The main focus of this study was the neonatal outcomes of singleton live births, including preterm birth (PTB), low birth weight (LBW), small for gestational age (SGA), macrosomia and large for gestational age (LGA).ResultsAfter 1:1 PSM, a total of 457 PPOS and 457 GnRH antagonist protocols were included for analysis. The average starting dose of gonadotropin (275.1 ± 68.1 vs. 249.3 ± 71.3, P&lt;0.01) and total dose of gonadotropin (2799.6 ± 579.9 vs. 2634.4 ± 729.1, P&lt;0.01) were significantly higher in the PPOS protocol than in the GnRH antagonist protocol. The other baseline and cycle characteristics were comparable between the two protocols. The rates of PTB (P=0.14), LBW (P=0.11), SGA (P=0.31), macrosomia (P=0.11) and LGA (P=0.49) did not differ significantly between the two groups. A total of 4 patients in the PPOS group and 3 patients in the GnRH antagonist group qualified as having congenital malformations.ConclusionPPOS resulted in singleton neonatal outcomes similar to those of a GnRH antagonist protocol. The application of the PPOS protocol is a safe option for infertility patients.
Evidence for increased interferon type I activity in CD8+ T cells in giant cell arteritis patients
Authors: van Nieuwland Marieke , Esen Idil , Reitsema Rosanne D. , Abdulahad Wayel H. , van Sleen Yannick , Jiemy William F. , Sandovici Maria , Brouwer Elisabeth , van Bon Lenny 
Published: June 2023

IntroductionGiant cell arteritis (GCA) is a vasculitis of the medium- and large-sized arteries. Interferon type I (IFN-I) is increasingly recognized as a key player in autoimmune diseases and might be involved in GCA pathogenesis, however evidence is limited. IFN-I activates Janus kinase/signal transducers and activators of transcription (JAK-STAT) pathways, leading to increased expression of interferon stimulated genes. In this study, IFN-I activity in GCA is explored, focusing on CD8+ T cells.MethodsExpression of phospho-STAT (pSTAT) 1, 3 and 5 was investigated in IFN-α-stimulated peripheral mononuclear cells (PBMCs) gated separately for CD8+ T cells of patients with GCA (n=18), healthy controls (HC, n=15) and infection controls (n=11) by Phosphoflow method combined with fluorescent cell barcoding technique. Furthermore, IFN-I induced myxovirus-resistance protein A (MxA) and CD8+ T cell expression was investigated by immunohistochemistry in temporal artery biopsies (TAB) of GCA patients (n=20) and mimics (n=20), and in aorta tissue of GCA (n=8) and atherosclerosis patients (n=14).ResultspSTAT1 expression was increased in IFN-α stimulated CD8+ T cells from GCA patients, whereas no difference was observed in pSTAT3 and pSTAT5 expression. MxA was present in TABs of 13/20 GCA patients compared to 2/20 mimics and in 8/8 GCA+ compared to 13/14 GCA- aorta tissues. MxA location partially co-localized with CD8+T cells.ConclusionsOur results provide evidence for increased IFN-I activity in CD8+ T cells of GCA patients, both systemically and locally. These findings warrant further investigation regarding IFN-I induced biomarkers and IFN-I related novel therapeutic options in GCA.
Germicidal effect of hydrogen peroxide nano-silver ion composite disinfectant and its effect on the microbial community of shrimp intestine and rearing water
Authors: Hou Danqing , Lin Zexu , Zhou Jianing , Xue Yuan , Sun Chengbo 
Published: June 2023

In this study, the inhibitory effect of different doses of hydrogen peroxide nano-silver ion composite disinfectant (HPS) on DIV1 and bacteria was analyzed, and the antibacterial activity of three disinfectants, HPS, potassium monopersulfate (KMPS) and calcium hypochlorite (Ca(ClO)2), was compared. In addition, 16S rDNA amplification sequencing technology was used to analyze the effects of these three disinfectants on the intestinal microflora of Litopenaeus vannamei and the structure and composition of water microflora. The results showed that HPS did not positively affect the survival rate of prawns infected with DIV1, which needs to be verified in future studies. In the experimental design range, the higher the dosage of HPS, the more obvious the killing effect on the number of Vibrio and total bacteria in rearing water, and the two showed a negative correlation. 5,104 OTUs were obtained based on 16S rDNA high-throughput sequencing, of which 3,012 (59.01%) and 1,475 (28.90%) OUTs were annotated at the phylum and genus levels, respectively. Proteobacteria, Firmicutes, Actinobacteriota, Bacteroidetes, and Cyanobacteria dominated the water samples at the phylum level. At the genus level, the dominant bacterial genera in the intestinal bacterial community of shrimp were Photobacterium, Vibrio, and Ruegeria. The most dominant bacteria genera in water samples were Vibrio, Ruegeria, Pseudoalteromonas, and Nautella. In the water samples, the composition and structure of the Ca(ClO)2 microbial community were relatively simple, and the species richness and diversity of Ca(ClO)2 were significantly lower than those of HPS and KMPS disinfectant groups at 12 h and 24 h (p &lt; 0.05). In terms of inhibiting the diversity and richness of the microbial community, Ca(ClO)2 had a significant effect (p &lt; 0.05), but the intestinal microbial community diversity of shrimp treated with HPS was higher than that of the other two groups. It is worth noting that, compared with the three disinfectants, HPS has the strongest killing effect on Vibrio and total bacteria, and has a certain positive significance for maintaining the stable state of the microbial community. This study provides a scientific basis for applying HPS in aquaculture and broadens the application range of HPS.