bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of BRAF, CCND1, and MYC mutations in a patient with multiple primary malignant tumors: a case report and review of the literature
Authors: Liu Zheyu , Jin Cheng , Zhang Yi , Jiang Yongquan , Wang Jingshuo , Zheng Luying 
Published: May 2023

Abstract
Background
Multiple primary malignant tumors (MPMTs), usually associated with worse malignant behavior and prognosis comparing to a single primary tumor, and have recently been found to have an increasing incidence globally. However, the pathogenesis of MPMTs remains to be clarified. Here, we report a unique case of the coexistence of malignant melanoma (MM), papillary thyroid carcinoma (PTC), and clear-cell renal cell carcinoma (ccRCC) along with our perceptions on its pathogenesis.

Case presentation
The case reported is of a 59-year-old male patient with unilateral nasal obstruction as well as a renal occupying lesion. Positron emission tomography-computed tomography (PET-CT) revealed a palpable mass of 32 × 30 mm on the posterior and left walls of the nasopharynx. In addition, an isodense nodule was observed in the right superior renal pole, approximately 25 mm in diameter, as well as a slightly hypodense shadow in the right leaf of the thyroid, approximately 13 mm in diameter. Nasal endoscopy and magnetic resonance imaging (MRI) confirmed the existence of a nasopharyngeal neoplasm. Afterward, biopsies of the nasopharyngeal neoplasm, thyroid gland and kidney were performed, and the patient was diagnosed with MM, PTC, and ccRCC according to the pathological and immunohistochemical results. Moreover, mutation of BRAFV600E was detected in bilateral thyroid tissues, and amplification of both CCND1 and MYC oncogenes were detected in the nasopharyngeal melanoma. After chemotherapy, the patient is now in good overall condition.

Conclusions
This is the first reported case of a patient with the co-existence of MM, PTC and ccRCC undergoing chemotherapy with a favorable prognosis. Herein, we suggest that such a combination may be non-random, as for mutation of BRAFV600E might account for the co-occurrence of PTC and MM, while mutations of CCND1 and MYC cause the coexistence of MM and ccRCC. This finding may provide valuable guidance on the diagnosis and treatment of such disease, as well as the prevention of developing a second or third tumor for patients with a single primary.
The effectiveness of spinal manipulative therapy procedures for spine pain: protocol for a systematic review and network meta-analysis
Authors: Nim Casper G. , Aspinall Sasha L. , Cook Chad E. , Corrêa Leticia A. , Donaldson Megan , Downie Aron S. , Harsted Steen , Hartvigsen Jan , Jenkins Hazel J. , McNaughton David , Nyirö Luana , Perle Stephen M. , Roseen Eric J. , Young James J. , Young Anika , Zhao Gong-He , Juhl Carsten B. 
Published: May 2023

Abstract
Background
Spinal manipulative therapy (SMT) is a guideline-recommended treatment option for spinal pain. The recommendation is based on multiple systematic reviews. However, these reviews fail to consider that clinical effects may depend on SMT “application procedures” (i.e., how and where SMT is applied). Using network meta-analyses, we aim to investigate which SMT “application procedures” have the greatest magnitude of clinical effectiveness for reducing pain and disability, for any spinal complaint, at short-term and long-term follow-up. We will compare application procedural parameters by classifying the thrust application technique and the application site (patient positioning, assisted, vertebral target, region target, Technique name, forces, and vectors, application site selection approach and rationale) against: 1. Waiting list/no treatment; 2. Sham interventions not resembling SMT (e.g., detuned ultrasound); 3. Sham interventions resembling SMT; 4. Other therapies not recommended in clinical practice guidelines; and 5. Other therapies recommended in clinical practice guidelines. Secondly, we will examine how contextual elements, including procedural fidelity (whether the SMT was delivered as planned) and clinical applicability (whether the SMT is similar to clinical practice) of the SMT.

Methods
We will include randomized controlled trials (RCT) found through three search strategies, (i) exploratory, (ii) systematic, and (iii) other known sources. We define SMT as a high-velocity low-amplitude thrust or grade V mobilization. Eligibility is any RCT assessing SMT against any other type of SMT, any other active or sham intervention, or no treatment control on adult patients with pain in any spinal region. The RCTs must report on continuous pain intensity and/or disability outcomes. Two authors will independently review title and abstract screening, full-text screening, and data extraction. Spinal manipulative therapy techniques will be classified according to the technique application and choice of application sites. We will conduct a network-meta analysis using a frequentist approach and multiple subgroup and sensitivity analyses.

Discussion
This will be the most extensive review of thrust SMT to date, and will allow us to estimate the importance of different SMT application procedures used in clinical practice and taught across educational settings. Thus, the results are applicable to clinical practice, educational settings, and research studies.
PROSPERO registration: CRD42022375836.
TMT proteomics analysis reveals the mechanism of bleomycin-induced pulmonary fibrosis and effects of Ginseng honeysuckle superfine powdered tea
Authors: Li Xiaoli , Yu Xin , Gao Yuan , Zhao Wenqian , Wang Yajuan , Yu Fei , Fu Chunli , Gao Haiqing , Cheng Mei , Li Baoying 
Published: May 2023

Abstract
Background
Pulmonary fibrosis (PF) is a chronic and potentially fatal lung disease and disorder. Although the active ingredients of ginseng honeysuckle superfine powdered tea (GHSPT) have been proven to have anti-inflammatory and antioxidant effects, the mechanism of GHSPT on PF remains unclear. The present study was to explore the underlying mechanism of GHSPT in treating PF based on proteomics and network pharmacology analysis and to confirm it in vivo.

Materials and methods
We used intratracheal instillation of bleomycin to induce the PF mouse model and GHSPT (640 mg/kg) intragastrically administrated to PF mice for 21 days. The lung tissues were harvested for TMT-based proteomics. The UPLC-Q-Exactive MS/MS analyze the serum migrant compounds of GHSPT in the PF mice. Moreover, components of GHSPT were harvested from the pharmacology database of the TCMSP system. PF-related targets were retrieved using NCBI and GeneCards databases.

Results
Our results showed that GHSPT significantly alleviated PF mice. Proteomics analysis showed that 525 proteins had significantly changed in the lung of untreated PF mice. Among them, 19 differential proteins were back-regulated to normal levels after GHSPT therapy. Moreover, 25 compounds originating from GHSPT were identified in the serum sample. Network analysis showed 159 active ingredients and 92 drug targets against PF. The signaling pathways include apoptosis, ferroptosis, cytokine-cytokine receptor, P53, and PI3K-Akt signaling pathway.

Conclusion
The evidence suggests that GHSPT might play an effective role in the treatment of PF by multi-target interventions against multiple signaling pathways.
Comparison of landiolol and amiodarone for the treatment of new-onset atrial fibrillation after cardiac surgery (FAAC) trial: study protocol for a randomized controlled trial
Authors: Caspersen Edouard , Guinot Pierre-Grégoire , Rozec Bertrand , Oilleau Jean-Ferréol , Fellahi Jean-Luc , Gaudard Philippe , Lorne Emmanuel , Mahjoub Yazine , Besnier Emmanuel , Moussa Mouhamed Djahoum , Mongardon Nicolas , Hanouz Jean-Luc , Briant Anaïs R. , Paul Laure Peyro Saint , Tomadesso Clémence , Parienti Jean-Jacques , Descamps Richard , Denisenko Alina , Fischer Marc-Olivier ,   for the ARCOTHOVA Group
Published: May 2023

Abstract
Background
Postoperative atrial fibrillation (PoAF) after cardiac surgery has a high incidence of 30%, but its management is controversial. Two strategies are recommended without evidence of a superiority of one against the other: rate control with beta-blocker or rhythm control with amiodarone. Landiolol is a new-generation beta-blocker with fast onset and short half-life. One retrospective, single-center study compared landiolol to amiodarone for PoAF after cardiac surgery with a better hemodynamic stability and a higher rate of reduction to sinus rhythm with landiolol, justifying the need for a multicenter randomized controlled trial. Our aim is to compare landiolol to amiodarone in the setting of PoAF after cardiac surgery with the hypothesis of a higher rate of reduction to sinus rhythm with landiolol during the 48 h after the first episode of POAF.

Methods
The FAAC trial is a multicenter single-blind two parallel-arm randomized study, which planned to include 350 patients with a first episode of PoAF following cardiac surgery. The duration of the study is 2 years. The patients are randomized in two arms: a landiolol group and an amiodarone group.
Randomization (Ennov Clinical®) is performed by the anesthesiologist in charge of the patient if PoAF is persistent for at least 30 min after correction of hypovolemia, dyskalemia, and absence of pericardial effusion on a transthoracic echocardiography done at bedside.
Our hypothesis is an increase of the percentage of patients in sinus rhythm from 70 to 85% with landiolol in less than 48 h after onset of PoAF (alpha risk = 5%, power = 90%, bilateral test).

Discussion
The FAAC trial was approved by the Ethics Committee of EST III with approval number 19.05.08. The FAAC trial is the first randomized controlled trial comparing landiolol to amiodarone for PoAF after cardiac surgery. In case of higher rate of reduction with landiolol, this beta-blocker could be the drug of choice used in this context as to reduce the need for anticoagulant therapy and reduce the risk of complications of anticoagulant therapy for patients with a first episode of postoperative atrial fibrillation after cardiac surgery.

Trial registration
ClinicalTrials.gov NCT04223739. Registered on January 10, 2020.
Software compatibility analysis for quantitative measures of [18F]flutemetamol amyloid PET burden in mild cognitive impairment
Authors: Pemberton Hugh G. , Buckley Christopher , Battle Mark , Bollack Ariane , Patel Vrajesh , Tomova Petya , Cooke David , Balhorn Will , Hegedorn Katherine , Lilja Johan , Brand Christine , Farrar Gill 
Published: May 2023

Abstract
Rationale
Amyloid-β (Aβ) pathology is one of the earliest detectable brain changes in Alzheimer’s disease pathogenesis. In clinical practice, trained readers will visually categorise positron emission tomography (PET) scans as either Aβ positive or negative. However, adjunct quantitative analysis is becoming more widely available, where regulatory approved software can currently generate metrics such as standardised uptake value ratios (SUVr) and individual Z-scores. Therefore, it is of direct value to the imaging community to assess the compatibility of commercially available software packages. In this collaborative project, the compatibility of amyloid PET quantification was investigated across four regulatory approved software packages. In doing so, the intention is to increase visibility and understanding of clinically relevant quantitative methods.

Methods
Composite SUVr using the pons as the reference region was generated from [18F]flutemetamol (GE Healthcare) PET in a retrospective cohort of 80 amnestic mild cognitive impairment (aMCI) patients (40 each male/female; mean age = 73 years, SD = 8.52). Based on previous autopsy validation work, an Aβ positivity threshold of ≥ 0.6 SUVrpons was applied. Quantitative results from MIM Software’s MIMneuro, Syntermed’s NeuroQ, Hermes Medical Solutions’ BRASS and GE Healthcare’s CortexID were analysed using intraclass correlation coefficient (ICC), percentage agreement around the Aβ positivity threshold and kappa scores.

Results
Using an Aβ positivity threshold of ≥ 0.6 SUVrpons, 95% agreement was achieved across the four software packages. Two patients were narrowly classed as Aβ negative by one software package but positive by the others, and two patients vice versa. All kappa scores around the same Aβ positivity threshold, both combined (Fleiss’) and individual software pairings (Cohen’s), were ≥ 0.9 signifying “almost perfect” inter-rater reliability. Excellent reliability was found between composite SUVr measurements for all four software packages, with an average measure ICC of 0.97 and 95% confidence interval of 0.957–0.979. Correlation coefficient analysis between the two software packages reporting composite z-scores was strong (r2 = 0.98).

Conclusion
Using an optimised cortical mask, regulatory approved software packages provided highly correlated and reliable quantification of [18F]flutemetamol amyloid PET with a ≥ 0.6 SUVrpons positivity threshold. In particular, this work could be of interest to physicians performing routine clinical imaging rather than researchers performing more bespoke image analysis. Similar analysis is encouraged using other reference regions as well as the Centiloid scale, when it has been implemented by more software packages.
Where internal medical patients receive intensive interventions: results from a tertiary-care hospital in Israel
Authors: Leibner Gideon , Brammli-Greenberg Shuli , Katz David , Esayag Yaakov , Kaufman Nechama , Rose Adam J. 
Published: May 2023

Abstract
Background
Patients admitted to internal medicine may be moved to more advanced-care settings when their condition deteriorates. In these advanced care settings, there may be higher levels of monitoring and greater ability to deliver Intensive Medical Treatments (IMTs). To the best of our knowledge, no previous study has examined the proportion of patients at different levels of care who receive different types of IMTs.

Methods
In this retrospective observational cohort study, we examined data from 56,002 internal medicine hospitalizations at Shaare Zedek Medical Center, between 01.01.2016 and 31.12.2019. Patients were divided according to where they received care: general-ward, Intermediate-Care Unit, Intensive Care Unit (ICU), or both (Intermediate-Care and ICU). We examined the rates at which these different groups of patients received one or more of the following IMTs: mechanical ventilation, daytime bi-level positive airway pressure (BiPAP), or vasopressor therapy.

Results
Most IMTs were delivered in a general-ward setting – ranging from 45.9% of IMT-treated hospitalizations involving combined mechanical ventilation and vasopressor therapy to as high as 87.4% of IMT-treated hospitalizations involving daytime BiPAP. Compared to ICU patients, Intermediate-Care Unit patients were older (mean age 75.1 vs 69.1, p < 0.001 for this and all other comparisons presented here), had longer hospitalizations (21.3 vs 14.5 days), and were more likely to die in-hospital (22% vs 12%). They were also more likely to receive most of the IMTs compared to ICU patients. For example, 9.7% of Intermediate-Care Unit patients received vasopressors, compared to 5.5% of ICU patients.

Conclusion
In this study, most of the patients who received IMTs actually received them in a general-bed and not in a dedicated unit. These results imply that IMTs are predominantly delivered in unmonitored settings, and suggest an opportunity to re-examine where and how IMTs are given. In terms of health policy, these findings suggest a need to further examine the setting and patterns of intensive interventions, as well as a need to increase the number of beds dedicated to delivering intensive interventions.
Early numeracy and literacy skills and their influences on fourth-grade mathematics achievement: a moderated mediation model
Authors: Chang Isabelle 
Published: May 2023

AbstractThis study explored the influence of early literacy and numeracy skills on fourth-grade math achievement using the Trends in International Mathematics and Science Study (TIMSS). The study utilized valuable information collected by TIMSS about context related questionnaires such as home resources for learning, early literacy and numeracy development, readiness for school, and students’ home and school lives in a cross cultural and linguistic framework. The main purpose of this study was aligned with those of TIMSS to improve math learning and performance and strengthen future employees’ skills in the global workplace. Participants were comprised of mostly Asian and European students. Results show that (1) early literacy skills have a stronger effect on G4 math scores than early numeracy skills; (2) Home resources for learning impact more on children’s early literacy skills than early numeracy skills; (3) both early literacy and numeracy activities have progressed to early literacy skills but demonstrated limited advancement to early numeracy skills, a missing link; (4) students’ confidence in math emerged as the strongest predictor of G4 math scores; (5) students with stronger early literacy skills and early numeracy skills are more confident in math; and (6) The moderated mediation analysis revealed that (a) early literacy skills have stronger direct effects on G4 math achievement than early numeracy skills; (b) the effects of early numeracy skills on G4 math scores become more pronounced for children with weaker early literacy skills (i.e., conditional effects); and (c) the effect of early numeracy skills on G4 math achievement is transmitted through students’ confidence (i.e., mediator) and the effect is more prominent for those who had more proficient early literacy skills (i.e., conditional indirect effects). Findings from the conditional direct and indirect effects of early numeracy skills on G4 math achievement suggest that children who had more proficient early literacy skills utilize strategies beyond just early numeracy skills to solve G4 math problems and that children’s strategies to solve math problems may be enhanced by the proficiency of their literacy skills.
Revolutionising textile manufacturing: a comprehensive review on 3D and 4D printing technologies
Authors: Manaia João P. , Cerejo Fábio , Duarte João 
Published: May 2023

AbstractAn exhaustive and integrative overview of recent developments in 3D and 4D textiles based on Additive Manufacturing (AM) were provided in order to identify the current state‐of‐the‐art. Despite all scientific progress, AM applied on textiles is a challenging technique and is still at an embryonic stage of research and technological development (R&TD), mainly due to the technological gap between featured prototypes and scalability in manufacturing. Despite its full potential across a range of different applications, such as development of functional filament fibres/wires, 3D printing on textiles, 3D printing completed garments and 4D textiles, needs future developments. Although, AM applied on textiles, enables cost and resource efficiency for small scale production through localised production, shorten supply chain and demand driven manufacture, both customisable and scalable, embracing cost and environmental sustainability. The opportunities and limits of 3D and 4D printing textiles are also discussed. Finally, the conclusion highlights the potential future development and application of the convergence of advanced computational design techniques, product customization, mathematical modelling, simulation, and digital modelling within multifunctional textiles.
Graphical Abstract
Image quality and radiation dose assessment for the clinically applied 16-slice CT scanner using PMMA phantom and quality assurance phantom
Authors: Mekonin Tadelech Sisay , Deressu Tilahun Tesfaye 
Published: May 2023

AbstractThe goal of this study was to assess the radiation dose delivered accuracy and the acceptable image quality parameter from the 16-slice Philips CT scanner in order to evaluate the current methodology for quality controls of computed tomography systems. The measured volume computed tomography dose index was 101 mGy and the displayed volume computed tomography dose index was 10.2 mGy and the dose length product is 680 mGy*cm for head scan, and the measured volume computed tomography dose index was 6.1 mGy and the displayed volume computed tomography dose index was 6.3 mGy and the dose length product was 587 mGy*cm for body scan, respectively. The image quality parameters were 4.4 HU, 2.3 HU, and 10 HU for uniformity, contrast-to-noise ratio, and computed tomography number accuracy (CT number accuracy) for quality assurance phantom, respectively. We propose that discussions and collaboration regarding patient and particular equipment adjustments be coordinated among radiologists, medical imaging technologists, and medical physicists. This can increase image quality, reduce absorbed radiation, and improve hospital medical care.
Circumstances of suicide after registration with a national digital mental health service: an analysis of coroners’ reports
Authors: Nielssen Olav , Staples Lauren , Karin Eyal , Ryan Katie , Kayrouz Rony , Dear Blake , Cross Shane , Titov Nickolai 
Published: May 2023

Background
Little is known about the safety of mental healthcare provided remotely by digital mental health services (DMHS), which do not offer face-to-face contact.

Aims
To examine the circumstances of suicide by patients registered with a national DMHS.

Method
Data from 59 033 consenting patients registered with a national DMHS, the MindSpot Clinic, between 1 January 2013 and 31 December 2016 were linked with the Australian National Death Index and documents held by the National Coronial Information System (NCIS). Data extracted included demographic information, the nature of contact, duration between last contact and death, symptom scores and information in police, autopsy, toxicology and coroners’ reports.

Results
Of the 59 033 patients, 90 (0.15%) died by suicide in a follow-up period of up to 5 years. The mean time between last contact and death was 560 days. Coroners’ reports were located for 81/90 patients. Most (87.0%) were receiving face-to-face care around the time of death, 60.9% had a documented previous suicide attempt, 52.2% had been in hospital in the previous 6 months and 22.2% had severe mental illness, mainly schizophrenia or bipolar disorder. Other common findings were current treatment with psychotropic medication (79.2%) and the presence of alcohol (41.6%), benzodiazepines (31.2%), and illegal drugs and non-prescribed opioids (20.8%) at time of death.

Conclusions
Those who died by suicide after contact with the DMHS had more severe illness, were mostly engaged with face-to-face services and often had disinhibiting substances, especially benzodiazepines, present at the time of death.
Introduction: Richard Rorty, Pragmatic Provocateur
Authors: Allen Barry , Rorty Richard , Gaskill Nicholas , Voparil Chris , Smith Barbara Herrnstein 
Published: May 2023

Abstract
This essay introduces a running symposium on the work of Richard Rorty and its legacy fifteen years after his passing. The arc of Rorty's thought defines a trajectory through American pragmatism, tracing a variation unimagined until he expressed it. His work raised Anglophone philosophers’ interest in American pragmatism as never before and also focused the interest of the whole world on American pragmatism as never before, even though the result was to define a pragmatism saturated with nominalism and suppressing the most original qualities of the sources that he celebrated.