bluuebunny/crossref_metadata_2025_split huggingface dataset:
Historical tsunami observability for Izu–Bonin–Mariana sources
Authors: Szeliga Walter , Reisinger Rachelle , MacInnes Breanyn 
Published: December 2022

AbstractThe Izu–Bonin–Mariana Subduction System (IBM) is one of the longest subduction zones in the world with no instrumental history of shallow focus, great earthquakes (Mw > 8). Over the last 50 years, researchers have speculated on the reason for the absence of large magnitude, shallow seismicity on this plate interface, exploring factors from plate age to convergence rate. We approach the question from a different point of view: what if the IBM has hosted great earthquakes and no documentable evidence was left? To address the question of observability, we model expected tsunami wave heights from nine great earthquake scenarios on the IBM at selected locations around the Pacific Basin with an emphasis on locations having the possibility for a long, written record. Many circum-Pacific locations have extensive written records of tsunami run-up with some locations in Japan noting tsunami back to 684 CE. We find that most IBM source models should theoretically be observable at historically inhabited locations in the Pacific Basin. Surprisingly, however, some IBM source models for earthquakes with magnitudes as high as Mw 8.7 produce tsunami wave heights that would be essentially unobservable at most historically populated Pacific Basin locations. These scenarios aim to provide a constraint on the upper bound for earthquake magnitudes in the IBM over at least the past 400 years.Graphical Abstract
Numerical investigation of the settlement behavior of hybrid system of floating stone columns and granular mattress in soft clay soil
Authors: Yasser Fayrouz , Altahrany Ayman , Elmeligy Mahmoud 
Published: December 2022

AbstractThe composite system of stone columns reinforced soil overlaid by granular mattress (GM) has been given more attention as a hybrid improvement technique. This work presents 3D finite element analyses using PLAXIS 3D software for a composite system of floating stone columns group constructed in a deep soft clay deposit in Port-Said in Egypt. The limited area of loading was investigated in conjunction with the system key parameters, i.e., length, diameter, and the GM main properties. Results validated the effectiveness of the GM in settlement reduction and system behavior enhancement. The GM thickness results in considerable settlement reduction up to value of 1.5d where d is the stone column diameter. The thickness increase can be an economical substitution instead of increasing stone column length where a new factor named “Mattress improvement factor: Ƞgm” is defined to represent the occurring improvement due to GM existence. Results also show notable reduction of settlement with increasing the length to a limiting value of L = 1.8B where B is the footing width.
Stunting and thinness in school-attending adolescents in Addis Ababa
Authors: Yallew Walelegn Worku , Tadesse Amare Worku , Noor Ramadhani Abdallah , Fawzi Wafaie , Berhane Yemane 
Published: December 2022

Abstract
Background
Adolescent population Global Diet Quality Score (GDQS) is uncommon in low-income settings. Though Global Diet Quality Score is a good measure of dietary diversity, it has not been used in assessing nutritional outcomes among adolescents. Therefore, the aim of this study is to assess school-attending adolescents stunting and thinness status and associations with global diet quality scores in Addis Ababa.

Methods
A school-based cross-sectional study was conducted among school-attending adolescents in the age group of 10–14 years in urban settings in Ethiopia. A multi-stage stratified random sampling procedure was used to select schools and students. A total of 1200 adolescents were included in the study. Binary and Multinomial logistic regression analyses were used to determine the predictors of stunting and thinness respectively.

Results
The proportion of school-attending adolescents stunting was 8.17% (95% CI: 6.74%,9.85%) and their thinness status 12.66% (95% CI: 10.89%, 14.67%). The overall mean GDQS food groups for Seven days period consumed were 19.99 + 2.81 SD. Male adolescents were 1.95 times more likely to be stunted compared to female adolescents (1.95; 95%CI: 1.11,3.39). Frequent consumption of low-fat dairy increased the risk of thinness, while frequent consumption of citrus fruits and white root tubers decreased the risk of school-attending adolescents’ thinness.

Conclusion
The proportion of thin or stunted adolescents attending school was high still, about 1 in 10. Stunting and thinness have no association with the overall GDQS. Nutritional interventions need to consider frequent consumption of citrus fruits, low-fat dairy, and white roots and tubers in school adolescents’ nutritional programs. Further studies should validate the GDQS for stunting and thinness of school adolescents.
Evaluation of the effectiveness of the modified nutrition risk in the critically ill (mNUTRIC) score in critically ill patients affected by COVID-19 admitted to the intensive care unit (ICU)
Authors: Alikiaii Babak , Hashemi Seyed Taghi , Kiani Zahra , Heidari Zahra , Nazemroaya Behzad , Golparvar Mohammad , Daneshmanesh Somayyeh , Fattahpour Shirin , Amini Sepide , Shojaei Mehrnaz , Bagherniya Mohammad 
Published: December 2022

Abstract
Background
COVID-19 is a very harmful pandemic, and its recovery process is highly influenced by nutritional status; however, an appropriate nutritional scale has not yet been proposed for these patients. Therefore, the purpose of this study was to evaluate the effectiveness of the modified Nutrition Risk in the Critically ill (mNUTRIC) score in critically ill patients affected by COVID-19 admitted to the intensive care unit (ICU).

Material and methods
This was a cross-sectional study performed on 204 critically ill patients affected by COVID-19 admitted to the ICU wards. Evaluated indicators include the mNUTRIC Score as well as demographic, and biochemical indicators.

Results
A high percentage of COVID-19 patients (67.2%) had severe disease. Hospital and ICU stay (p > 0.001) and PH (p > 0.001) values were significantly lower in non-survivors than in survivors. mNUTRIC score (p > 0.001), PCO2 (p = 0.003), and CRP levels (p = 0.021) were significantly higher in non-survivors than survivors. mNUTRIC score had a direct correlation with age (p > 0.001), AST (p = 0.000), LDH (p = 0.026), and CRP (p = 0.014) and an inverse correlation with hospital duration (p = 0.031), albumin (p = 0.003) and PH (p < 0.001). Furthermore, there was a non-significant correlation between the mNUTRIC score and mortality chance (OR = 1.085, 95%CI [0.83, 1.42], p = 0.552). While, patients with more severe COVID-19 disease (OR = 8.057, 95%CI [1.33, 48.64], p = 0.023) and higher PCO2 (OR = 1.042, 95%CI [1.01, 1.08], p = 0.023) levels had higher odds of mortality.

Conclusions
Our findings revealed that COVID-19 patients with higher CRP levels and lower PH had higher mortality and poor nutritional condition. Moreover, there was a non-significant association between the mNUTRIC score and mortality chance.
Virulence of Metarhizium isolated from infected Oryctes rhinoceros L. (Coleoptera: Scarabaeidae) larvae around coconut plantations in East Java, Indonesia
Authors: Prastowo Sigit , Soeharto  , Addy Hardian Susilo , Handoyo Tri 
Published: December 2022

Abstract
Background
Metarhizium is one of the entomopathogenic fungi (EPF) that has been widely reported as a useful agent for controlling the coconut rhinoceros beetle (CRB), Oryctes rhinoceros L. (Coleoptera: Scarabaeidae). Application of this fungus as a biopesticide is influenced by regional environmental conditions that affect the pathogenic activity against the targeted pest. Several studies have proven that the native fungal isolates have strong pathogenic activity than EPF introduced from other regions. The identification of local EPF species is a strategic approach to develop potential biopesticides with standard properties including host specificity, climate suitability, and significantly suppressing the target pest population. This study aimed to identify Metarhizium species isolated from infected CRB larvae with high pathogenicity to host pests in East Java, Indonesia.

Results
Thirteen isolates were obtained which were divided into 4 clades based on phylogenetic analysis by the ITS rDNA region, namely M. anisopliae var. lepidiotae, M. anisopliae var. anisopliae, M. brunneum, and M. majus. Identified Metarhizium species exhibited varied sizes of conidia, but fell within the size ranges reported in previous studies. Interestingly, the isolate MaSi produced conidial lengths well above the range of conidial sizes recorded and placed these isolates (M. anisopliae) in the MGT clade, known as MALC (M. anisopliae s.l. with large conidia). The present investigation reported that isolates MaLe, MaMa, MaWa, and MaSi produced higher mortality values than other isolates, supporting that M. majus and MALC had higher pathogenicity against O. rhinoceros larvae than other Metarhizium species. Neighbor-joining analysis showed a close resemblance between the isolate MaMa and the strain ARSEF 1946, which was isolated from the CRB. In addition, the isolate MaMa had the highest virulence against O. rhinoceros larval cadaver with a faster lethal time (for 50% mortality). This result indicated a possible relationship between phylogenetic status or DNA sequence polymorphisms with Metarhizium pathogenicity and host specificity.

Conclusions
The local species of Metarhizium have been isolated from infected CRB larvae, and M. majus isolates exhibited high pathogenicity against O. rhinoceros larvae. The close similarity of M. majus isolates and CRB-isolated strains suggests a possible relationship between pathogenicity and host specificity with phylogenetic status or DNA sequence polymorphisms.
Exome sequencing identified a novel Col6α1 mutation in an Iranian patient with Ullrich congenital muscular dystrophy: a case report
Authors: Nekouei Elaheh , Yancheshmeh Elmira Shokrolahi , Mohammadi-Asl Javad , Moghaddam Zafar Maasoumi 
Published: December 2022

Abstract
Introduction
Ullrich congenital muscular dystrophy (UCMD) is a severe form of inherited muscle weakness at birth. Recent genetic studies discovered that different gene mutations are responsible for UCMD clinical manifestation.

Case report
In this study, we carried out whole exome sequencing (WES) to recognize probable gene defects in an Iranian boy with UCMD. We found a novel disease-causing COL6α1 gene mutation (c.2551_2562del; p.Phe851_Arg854del), located in exon35 (NM_001848.3), causing a deletion mutation that has eliminated 12 bp. The WES-identified variant that was confirmed by Sanger sequencing for the patient and his consanguineous parents. Here, we report the clinical manifestations of 4-year-old Iranian patient who presented with muscle weakness since birth and proved compound homozygous mutation of the COL6A1 gene.

Conclusion
Our findings established that this detected COL6α1 mutation is the pathogenic variant for UCMD. This is the first genetic study indicating that c.2551_2562 mutation in homozygous state in COL6α1 gene is responsible for the UCMD phenotype.
Coexistence of tubo-ovarian abscess and carcinoid tumor of the appendix in a sexually inactive girl: a case report
Authors: Acer-Demir Tuğba , Sağnak-Akıllı Müge , Güney Lütfi Hakan , Arslan Esra Elif , Fakıoğlu Ender 
Published: December 2022

Abstract
Background
Tubo-ovarian abscess (TOA) is mostly a sequela of pelvic inflammatory disease (PID) which is seen in sexually active women. Although very rare, TOA could be seen in virgin adolescent girls. Fifteen cases of TOA were reported in virgin girls in English literature. Only one of these cases was suspected to be due to appendicitis. Herein, we present the first case of coexistence of tubo-ovarian abscess and carcinoid tumor of the appendix in a sexually inactive girl.

Case presentation
A 13-year-old girl presented with abdominal pain and fever. Ultrasonography reported that there was a 63×48 mm sized, heterogeneous, thick-walled, dense-content complicated cyst in the right ovary which was thought to be a hemorrhagic cyst and a tubular structure, measuring 12 mm in its thickest part which was thought to be the appendix. During the operation, a TOA was observed in the right adnexal region. The thick, edematous appendix which was lying separately was excised. The TOA was evacuated; a drain was placed. The appendix pathology was reported as “carcinoid tumor.”

Conclusion
We present the first case of TAO with carcinoid tumor of appendix and the second case of TAO that was suspected to be due to appendicitis. When the sexually inactive TOA cases including our case were reviewed, we found that the median age was 15 years (12–47 years) and 11 of 16 cases (69%) were under 18 years of age. The presenting symptoms were abdominal or pelvic pain in all cases, fever in 11 cases (69%), vomiting in 6 cases (38%), dysuria in 5 cases (31%), and diarrhea in 3 cases (19%). Both perforated appendicitis and TOA patients have the same clinic presentation such as fever, abdominal tenderness, increased leukocyte count, increased inflammatory markers. The differential diagnosis can be achieved by radiological examinations such as ultrasonography, computerized tomography or magnetic resonance imaging.
Marine macroalgae polysaccharides-based nanomaterials: an overview with respect to nanoscience applications
Authors: Ahmad Khurshid , Khan Suleman , Afridi Mahideen , Hassan Ather , Shah Muhammad Musaddiq , Rasheed Hassam , Ahmad Rasheed , Ifqir Hajar 
Published: December 2022

Abstract
Background
Exploration of marine macroalgae poly-saccharide-based nanomaterials is emerging in the nanotechnology field, such as wound dressing, water treatment, environmental engineering, biosensor, and food technology.

Main body
In this article, the current innovation and encroachments of marine macroalgae polysaccharide-based nanoparticles (NPs), and their promising opportunities, for future prospect in different industries are briefly reviewed. The extraction and advancement of various natural sources from marine polysaccharides, including carrageenan, agarose, fucoidan, and ulvan, are highlighted in order to provide a wide range of impacts on the nanofood technology. Further, seaweed or marine macroalgae is an unexploited natural source of polysaccharides, which involves numerous different phytonutrients in the outermost layer of the cell and is rich in sulphated polysaccharides (SP), SP-based nanomaterial which has an enhanced potential value in the nanotechnology field.

Conclusion
At the end of this article, the promising prospect of SP-based NPs and their applications in the food sector is briefly addressed.
Prevalence of musculoskeletal pain among computer users working from home during the COVID-19 pandemic: a cross-sectional survey
Authors: Gosain Lakshita , Ahmad Irshad , Rizvi Moattar Raza , Sharma Ankita , Saxena Shobhit 
Published: December 2022

Abstract
Background
Office employees are at a greater risk for musculoskeletal disorders (MSD) due to their prolonged computer use. In the context of COVID-19, an unanticipated shift to working from home is likely to increase MSD due to a lack of an ergonomic workspace and longer workdays.

Aim
To explore the prevalence of MSD with work-related risk factors among the computer users working from home during the COVID-19 pandemic.

Study design
Cross-sectional survey.

Methods
Computer users working from home for more than 6 hours per day during the COVID-19 lockdown were assessed for possible work-related MSD using web-based survey—Google forms for Nordic Musculoskeletal Questionnaire.

Results
One hundred twenty one responses from 53 (43.8%) females (25.47 ± 5.72 years) and 68 (56.2%) males (28.65 ± 4.68 years) were included. The female participants were more prone to musculoskeletal pain as compared to males. The neck pain (60.3%), lower back pain (59.5%), and shoulder pain (49.6%) were the most reported body regions affected by work-related MSD. The elbow (18.2%), wrist/hand (35.5%), upper back (42.1%), hips (24.8%), knee (23.1%), and ankle/feet (14%) were the least affected regions. The risk factors associated with MSP includes lack of workplace at home during lockdown, stress after being in one posture, stress in eyes, and mental stress due to work.

Conclusions
During the lockdown phase, the transition of computer workers from working office environment to home increased the prevalence of MSD more commonly in females than males. There is a need to investigate early detection, prevention, and management options to enhance health outcomes.
Diagnostic strategy and therapeutic management of sinonasal inverted papilloma: our experience with review of literature
Authors: Bouatay Rachida , Farhati Amira , Abdelali Mabrouk , N Naourez kolsi , Korbi Amel El , Ferjaoui Mehdi , Harrathi Khaled , Koubaa Jamel 
Published: December 2022

Abstract
Background
The sinonasal inverted papilloma is a rare benign tumor, characterized by local aggressiveness, a high rate of recurrence after surgical resection, and the possibility of malignant transformation. The aims of this study are to analyze diagnostic strategy and therapeutic modalities and to evaluate results after surgery.

Methods
We report a retrospective study, including patients operated for inverted sinonasal papilloma in our department. Preoperatively, all patients were assessed by CT scan (computed tomography), 9 of them by MRI (magnetic resonance imaging).

Results
The average age of our patients was 52 years with a male predominance. The most common symptom was unilateral nasal obstruction. The endoscopic appearance was suggestive of inverted papilloma (IP) in 75% of cases. Thirty-two patients underwent an exclusive endonasal endoscopic surgery; one patient was operated with a combined approach. Two patients underwent external approaches. A recurrence was observed in 4 patients (11%).

Conclusion
Preoperative investigation for IP is essentially based on MRI, also required in case of recurrence. Histological examination of the entire tumor is crucial to rule out an associated carcinoma. The “all endoscopic” management is not always achievable for these tumors.
Cardiomyocyte differentiation from human induced pluripotent stem cells is delayed following knockout of Bcl-2
Authors: Vervliet Tim , Duelen Robin , Pradhan Ankit , La Rovere Rita , Roderick H. Llewelyn , Sampaolesi Maurilio 
Published: December 2022

ABSTRACT
Anti-apoptotic B-cell lymphoma 2 (Bcl-2) regulates a wide array of cellular functions involved in cell death, cell survival and autophagy. Less known is its involvement in the differentiation of cardiomyocytes. As a consequence, mechanisms by which Bcl-2 contributes to cardiac differentiation remain to be elucidated. To address this, we used CRISPR/Cas9 to knockout (KO) BCL2 in human induced pluripotent stem cells (hiPSCs) and investigated the consequence of this KO for differentiation towards cardiomyocytes. Our results indicate that differentiation of hiPSCs to cardiomyocytes was delayed following BCL2 KO. This was not related to the canonical anti-apoptotic function of Bcl-2. This delay led to reduced expression and activity of the cardiomyocyte Ca2+ toolkit. Finally, Bcl-2 KO reduced c-Myc expression and nuclear localization in the early phase of the cardiac differentiation process, which accounts at least in part for the observed delay in the cardiac differentiation. These results suggest that there is a central role for Bcl-2 in cardiomyocyte differentiation and maturation.
Applying negative binomial regression analysis to overcome the overdispersion of Poisson regression model for malnutrition cases in Indonesia
Authors: Setyawan Yudi , Suryowati Kris , Octaviana Dita 
Published: December 2022

Indonesia is one of the developing countries that is struggling to eradicate malnutrition problem. Malnutrition that occurs over a long period of time can have an impact on deaths for the sufferers and decreasing human’s quality of life. This study aims to model the case of malnutrition that occurred in Indonesia Provinces during 2015, and get the main factors that cause malnutrition problem. Variables studied consists of Malnutrition (Y), Vitamin A consumption (X1), Exclusive breastfeeding (X2), Immunization (X3), Water quality (X4), Healthcare center (X5), and Poverty level (X6). Based on the Kolmogorov-Smirnov test, the results of malnutrition data in Indonesia Province in 2015 does not follow Poisson distribution because of overdispersion. The presence of overdispersion cases in the Poisson regression model will have an impact on the inappropriateness of inferences. An alternative model that can accomodate this case is negative binomial regression model. By using this model, factors that are considered influencing malnutrition cases in Indonesia provinces in 2015 are Immunization (X3), Water quality (X4), and Poverty level (X6). The best model obtained from negative binomial regression analysis is μ ̂_i=exp(2.5111-0.0338X_3+0.0295X_4+0.0576X_6).
Treatment of pediatric patients with traumatic brain injury by Dutch Helicopter Emergency Medical Services (HEMS)
Authors: Oude Alink Michelle , Moors Xavier , de Bree Pim , Houmes Robert Jan , den Hartog Dennis , Stolker Robert Jan 
Published: December 2022

Background
Sparse data are available on prehospital care by Helicopter Emergency Medical Service (HEMS) for pediatric patients with traumatic brain injury (TBI). This study focusses on prehospital interventions, neurosurgical interventions and mortality in this group.

Methods
We performed a retrospective analysis of pediatric (0–18 years of age) patients with TBI treated by Rotterdam HEMS.

Results
From January 2012 to December 2017 415 pediatric (<18 years of age) patients with TBI were included.
Intubation was required in in 92 of 111 patients with GCS ≤ 8, 92 (82.9%), compared to 12 of 77 (15.6%) with GCS 9–12, and 7 of 199 (3.5%) with GCS 13–15. Hyperosmolar therapy (HSS) was started in 73 patients, 10 with a GCS ≤8. Decompressive surgery was required in 16 (5.8%), nine patients (56.3%) of these received HSS from HEMS. Follow-up data was available in 277 patients. A total of 107 (38.6%) patients were admitted to a (P)ICU. Overall mortality rate was 6.3%(n = 25) all with GCS ≤8, 15 (60.0%) died within 24 hours and 24 (96.0%) within a week. Patients with neurosurgical interventions (N = 16) showed a higher mortality rate (18.0%).

Conclusions
The Dutch HEMS provides essential emergency care for pediatric TBI patients, by performing medical procedures outside of regular EMS protocol. Mortality was highest in patients with severe TBI (n = 111) (GCS≤8) and in those who required neurosurgical interventions.
Despite a relatively good initial GCS (>8) score, there were patients who required prehospital intubation and HSS. This group will require further investigation to optimize care in the future.