bluuebunny/crossref_metadata_2025_split huggingface dataset:
Supramolecular fibrous hydrogel augmentation of uterosacral ligament suspension for treatment of pelvic organ prolapse
Authors: Miller Beverly , Wolfe Wiley , Gentry James L. , Grewal M. Gregory , Highley Christopher B. , De Vita Raffaella , Vaughan Monique H. , Caliari Steven R. 
Published: January 2023

AbstractUterosacral ligament suspension (USLS) is a common surgical treatment for pelvic organ prolapse (POP). However, the relatively high failure rate of up to 40% underscores a strong clinical need for complementary treatment strategies, such as biomaterial augmentation. Herein, we describe the first hydrogel biomaterial augmentation of USLS in a recently established rat model using an injectable fibrous hydrogel composite. Supramolecularly-assembled hyaluronic acid (HA) hydrogel nanofibers encapsulated in a matrix metalloproteinase (MMP)-degradable HA hydrogel create an injectable scaffold showing excellent biocompatibility and hemocompatibility. The hydrogel can be successfully delivered and localized to the suture sites of the USLS procedure, where it gradually degrades over 6 weeks.In situmechanical testing 24 weeks post-operative in the multiparous USLS rat model shows the ultimate load (load at failure) to be 1.70 ± 0.36 N for the intact uterosacral ligament (USL), 0.89 ± 0.28 N for the USLS repair, and 1.37 ± 0.31 N for the USLS + hydrogel (USLS+H) repair (n= 8). These results indicate that the hydrogel composite significantly improves load required for tissue failure compared to the standard USLS, even after the hydrogel degrades, and that this hydrogel-based approach could potentially reduce the high failure rate associated with USLS procedures.
The multimodal action of G alpha q in coordinating growth and homeostasis in theDrosophilawing imaginal disc
Authors: Velagala Vijay , Soundarrajan Dharsan K. , Unger Maria F. , Gazzo David , Kumar Nilay , Li Jun , Zartman Jeremiah 
Published: January 2023

AbstractBackgroundG proteins mediate cell responses to various ligands and play key roles in organ development. Dysregulation of G-proteins or Ca2+signaling impacts many human diseases and results in birth defects. However, the downstream effectors of specific G proteins in developmental regulatory networks are still poorly understood.MethodsWe employed the Gal4/UAS binary system to inhibit or overexpressGαqin the wing disc, followed by phenotypic analysis. Immunohistochemistry and next-gen RNA sequencing identified the downstream effectors and the signaling cascades affected by the disruption of Gαq homeostasis.ResultsHere, we characterized how the G protein subunit Gαq tunes the size and shape of the wing in the larval and adult stages of development. Downregulation ofGαqin the wing disc reduced wing growth and delayed larval development.Gαqoverexpression is sufficient to promote global Ca2+waves in the wing disc with a concomitant reduction in theDrosophilafinal wing size and a delay in pupariation. The reduced wing size phenotype is further enhanced when downregulating downstream components of the core Ca2+signaling toolkit, suggesting that downstream Ca2+signaling partially ameliorates the reduction in wing size. In contrast,Gαq-mediated pupariation delay is rescued by inhibition of IP3R, a key regulator of Ca2+signaling. This suggests that Gαq regulates developmental phenotypes through both Ca2+-dependent and Ca2+-independent mechanisms. RNA seq analysis shows that disruption of Gαq homeostasis affects nuclear hormone receptors, JAK/STAT pathway, and immune response genes. Notably, disruption of Gαq homeostasis increases expression levels of Dilp8, a key regulator of growth and pupariation timing.ConclusionGαq activity contributes to cell size regulation and wing metamorphosis. Disruption to Gαq homeostasis in the peripheral wing disc organ delays larval development through ecdysone signaling inhibition. Overall, Gαq signaling mediates key modules of organ size regulation and epithelial homeostasis through the dual action of Ca2+-dependent and independent mechanisms.
Structural insights into transcription activation mechanism of the global regulator GlnR from actinobacteria
Authors: Shi Jing , Feng Zhenzhen , Xu Juncao , Li Fangfang , Zhang Yuqiong , Wen Aijia , Wang Fulin , Song Qian , Wang Lu , Wang Shuang , Feng Yu , Lin Wei 
Published: January 2023

AbstractGlnR, an OmpR/PhoB subfamily protein, is an orphan response regulator that globally coordinates the expression of genes responsible for nitrogen, carbon and phosphate metabolism in actinobacteria. Although much efforts at biochemical and genetic analyses have been made on the mechanism of GlnR-dependent transcription activation, it still remains unclear owing to lacking the structure of GlnR-dependent transcription activation complex (GlnR-TAC). Here, we report a crystal structure of a binary complex including a C terminal DNA binding domain of GlnR (GlnR_DBD) and its regulatorycis-element DNA, and a cryo-EM structure of GlnR-TAC comprising ofMycobacterium tuberculosisRNA polymerase, GlnR, and a promoter containing four well-characterized conserved GlnR binding sites. These structures show four GlnR protomers coordinately engage promoter DNA in a head-to-tail manner, with two N-terminal receiver domains of GlnR (GlnR-RECs) jointly act as a bridge to connect RNAP αNTD with the upstream GlnR_DBD. GlnR-TAC is stabilized by complex protein-protein interactions between GlnR and the conserved β flap, σAR4, αCTD, αNTD domains of RNAP. These are in good agreement with our mutational and kinetic single-molecule fluorescence assays. Altogether, our results reveal a general transcription activation mechanism for the global regulator GlnR and other OmpR/PhoB subfamily proteins, and present a unique mode of bacterial transcription regulation.Significance statementIn low-GC gram-negative bacteria, the typical two component system NtrB/NtrC accounts for the expression of genes related to nitrogen metabolism. In high-GC gram-positive actinobacteria, GlnR, an atypical and orphan response regulator (RR) of the OmpR/PhoB subfamily proteins, globally coordinates transcription of genes involved in nitrogen, carbon and phosphate metabolism. Here, using crystallography, cryo-electron microscopy, and single-molecule fluorescence assays, we show that GlnR activates transcription by contacting DNA between the −10 and −35 elements and further upstream through contacting σ region 4 and RNAP β flap subunit. We also identify a previously unobserved cooperative engagement of four GlnR protomers to the promoter DNA, which not only makes the transcription initiation complex (RPo) more stable, but also provides better transcription activities.
Indigenous directorship pathways through transformative leadership: a content analysis of reconciliation action plans (RAPs)
Authors: Weerasinghe Ashesha Paveena , Chapple Larelle , Williamson Alexandra Kate 
Published: January 2023

PurposeThis paper aims to explore how corporate Australia engages in reconciliation through recognizing and providing pathways for Indigenous Australians' corporate leadership aspirations.Design/methodology/approachThe research design is informed by the prior literature on pathways by minority groups to corporate leadership through the theoretical lens of transformational leadership. The investigation is conducted using textual analysis of reconciliation action plans (RAPs), a contemporary and voluntary practice adopted by Australian listed companies to disclose their commitment to national reconciliation. RAPs are publicly available from the official websites of listed companies.FindingsThe analysis of contemporary RAPs highlights organizational initiatives to support Indigenous Australians related to corporate and community leadership. Since the authors’ focus is the former, corporate leadership initiatives are further analyzed. Two initiatives for Indigenous Australians to pursue corporate leadership positions are emerging future leaders' programs and mentoring programs. This is the extent to which the authors observe Australian firms' transformational leadership. While some firms have implemented these initiatives with specific targets, other firms do not have specific initiatives or targets. The paper also conducts longitudinal analysis into the transformational leaders' past RAPs and triangulates to other evidence of reconciliation commitment such as the Uluru Statement from the Heart.Research limitations/implicationsThis paper contributes new insights to the research area of board cultural diversity, specifically to the limited literature on Indigenous reconciliation. It provides insights into firms and policymakers to address the ongoing issue of the underrepresentation of Indigenous Australians in corporate leadership. The sample of firms comprises Australian listed firms that have adopted higher-order RAPs, which restricts the generalizability of the findings to other sectors.Originality/valueThis paper explores the under researched phenomenon of Indigenous people's pathways to corporate leadership. The research design is informed by transformational leadership theory through considering institutional actions for reconciliation. This research provides evidence of the extent to which corporate Australia has taken action on the issue of the under-representation of Australian Indigenous people in corporate leadership.
The different effects of venture capital and the trade-off between product innovation effectiveness and efficiency
Authors: Xiao Ting , Yang Zhi , Jiang Yanhui 
Published: January 2023

PurposeWhich venture capital is more beneficial in the product innovation of entrepreneurial ventures? The authors study the drawbacks and different effects of corporate venture capital (CVC) and independent venture capital (IVC) on the effectiveness and efficiency of product innovation in entrepreneurial ventures to answer this question.Design/methodology/approachThis study uses a panel dataset of 502 high-tech ventures and runs the Heckman model to correct potential endogeneity issues.FindingsThe authors find that CVC increases the product innovation effectiveness of entrepreneurial ventures, but decreases their efficiency. IVC reduces innovation effectiveness and enhances efficiency. However, CVC performs less positively, while IVC performs more positively in terms of innovation effectiveness and efficiency in the B2B market than in the B2C market.Practical implicationsThis study provides insights into how to leverage venture capital to develop new products effectively and efficiently.Originality/valueThis study moves beyond the current understanding of the finance-marketing interface. It delineates the two faces of venture capital and reveals the joint effects of equity stakes and market stakes between different types of venture capital and transaction markets in product innovation.
Agile project management as a stage for creativity: a conceptual framework of five creativity-conducive spaces
Authors: Olszewski Mieszko 
Published: January 2023

PurposeThe purpose of this paper is to demonstrate how agile project management can foster creativity in project teams.Design/methodology/approachThe study is based on an extensive literature review of agile project management and team creativity and is matching these two to answer the following research questions: (1) how agile project management approach can foster creativity in project teams? and (2) which principles and practices promoted by the most popular agile methodologies enhance creativity in project teams?FindingsFive creativity-conducive spaces in agile project management were identified and integrated into a conceptual framework, namely, a space for generative social interactions, a space for learning, a space for change and adaptation, a space for exploration and a space promoting team members' well-being. In the next step, based on a thorough analysis of seven widespread agile project management methods, a large number of agile principles and practices were mapped into each of the five conceptual spaces.Originality/valueThis study provides new insights into how agile project management can foster creativity in project teams. The conceptual framework developed in this paper might be utilized to enhance creativity in agile teams, it can also serve as a starting point for future research.
An ICT-based start-up entering maritime logistics networks: facilitation of value cocreation patterns
Authors: Göçer Aysu , Altuntas Vural Ceren , Lind Frida 
Published: January 2023

PurposeThis study aims to explore how a start-up entering maritime logistics networks (MLNs) in the container shipping industry integrates resources underlying value cocreation patterns in these networks.Design/methodology/approachThe paper is based on a single case study of a technological start-up, providing tracking, tracing and other information services to MLN members using internet-based software. An interorganizational theory perspective informs the case study to unveil the resource integration for value cocreation in the network.FindingsThe start-up holds multiple resource interaction roles and the start-up’s involvement enables the creation of new knowledge resources, which facilitate new revenue streams and manage resource dependencies. Hence, the findings indicate that the start-up changes value cocreation patterns in the network by reconfiguring and integrating existing resources so that the service is customized for various customers, including shippers and freight forwarders.Practical implicationsThe results provide insights about how technological start-ups can unlock resources within MLNs.Originality/valueThe study extends previous studies on resource roles in business networks and shows how start-ups can perform multiple roles simultaneously within these networks. In addition, the study contributes to the literature by studying information and knowledge as resources configured in different ways in a unique network setting.
Nutritional and quality attributes of bread fortified with cheeseweed mallow leaves powder
Authors: Mohammed Akram M. , El-Anany Ayman Mohammed , Althwab Sami A. , Alhomaid Raghad M. , Alharbi Hend F. , ALgheshairy Reham M. , Ali Rehab F.M. 
Published: January 2023

Purpose
The purpose of this current investigation is to evaluate the effect of adding different levels of cheeseweed Malva parviflora L. mallow leaves powder (MPLP) on the nutritional and quality characteristics of bread.

Design/methodology/approach
Wheat flour was partially replaced with MPLP at 0%, 1%, 2%, 3%, 4% and 5% levels to obtain the wheat– MPLP composite flour. Chemical composition, phenolics, flavonoids and antioxidant activity by 2,2-diphenyl-1-picrylhydrazyl of wheat flour and MPLP were determined. Physicochemical and sensory characteristics of bread enriched with various levels of MPLP were evaluated.

Findings
MPLP contains 23.9% of protein, 10.1% of crude fiber and 9.8% of ash, respectively. MPLP had a significantly higher concentration of micronutrients than wheat flour. The content of total phenolics, flavonoids as well as free radical scavenging activity of MPLP were 17.6, 38.2 and 6.0 fold, respectively, higher compared to wheat flour. Protein content in bread samples increased with the addition of the MPLP in a range of 1.2%–6.6%. The increasing replacement of MPLP in the composite flours resulted in progressively higher dietary fiber and ash contents for fortified bread samples. The higher level of MPLP reduced the specific volume of fortified breads. The highest scores for the sensory attributes were noted for bread samples fortified with 2% and 3% of MPLP, whereas the lowest scores for bread samples fortified with 4% and 5% MPLP.

Research limitations/implications
Supplementation of wheat bread with different levels of MPLP resulted in significant increases in macro and microelements of fortified breads.

Originality/value
Supplementation of wheat bread with different levels of cheeseweed Mallow (Malva parviflora L.) leaves powder resulted in significant increases in macro and microelements of fortified breads.
Market efficiency assessment for multiple exchanges of cryptocurrencies
Authors: Souza Orlando Telles , Carvalho João Vinícius França 
Published: January 2023

PurposeThis study aims to analyze the efficient market hypothesis (EMH) of cryptocurrencies on multiple platforms by observing whether there is a discrepancy in the levels of efficiency between different exchanges. Additionally, EMH is tested in a multivariate way: whether the prices of the same cryptocurrencies traded on different exchanges are temporally related to each other. ADF and KPSS tests, whereas the vector autoregression model of order p – VAR(p) – for multivariate system.FindingsBoth Bitcoin and Ethereum show efficiency in the weak form on the main platforms in each market alone. However, when estimating a VAR(p) between prices among exchanges, there was evidence of Granger causality between cryptocurrencies in all exchanges, suggesting that EMH is not adequate due to cross information.Practical implicationsIt is essential to assess the cryptocurrency market in a multivariate way, not only to favor its maturation process, but also to promote a broad understanding of its inherent risks. Thus, it will be possible to develop financial products that are actively managed in a more sophisticated cryptocurrency market.Social implicationsThere is a possibility of performing arbitrage on different exchanges and market assets through cross-exchanges. Thus, emphasizing the need for regulation of exchanges in the digital asset market, as an eventual price manipulation on a single platform can impact others, which generates various distortions.Originality/valueThis study is the first to find evidence of cross-information for the same (and other) cryptocurrencies among different exchanges.
Evaluating the association between expanded coverage of direct‐to‐consumer telemedicine and downstream utilization and quality of care for urinary tract infections and sinusitis
Authors: Yu Jiani , Huckfeldt Peter J. , Mink Pamela J. , Mehrotra Ateev , Abraham Jean M. 
Published: January 2023

AbstractObjectiveTo compare direct‐to‐consumer (DTC) telemedicine and in‐person visits in rates of testing, follow‐up health care use, and quality for urinary tract infections (UTIs) and sinusitis.Data SourceThe Minnesota All Payer Claims Data provided 2008–2015 administrative claims data.Study DesignUsing a difference‐in‐differences approach, we compared episodes of care for UTIs and sinusitis among enrollees of health plans introducing coverage for DTC telemedicine relative to those without DTC telemedicine coverage. Primary outcomes included number of laboratory tests, antibiotics filled, office and outpatient visits, emergency department (ED) visits, and standardized spending, based on standardized prices of health services.Data CollectionThe study sample included non‐elderly enrollees of commercial health insurance plans. We constructed 30‐day episodes of care initiated by a DTC telemedicine or in‐person visit.Principal FindingsThe UTI and sinusitis samples were comprised of 215,134 and 624,630 episodes of care, respectively. Following the introduction of coverage for DTC telemedicine, 15.7% of UTI episodes and 8.9% of sinusitis episodes were initiated with DTC telemedicine. Compared to episodes without coverage for DTC telemedicine, UTI episodes with coverage had 0.25 fewer lab tests (95% CI: −0.33, −0.18; p < 0.001), lower standardized spending for the first UTI visit (−$11.18 [95% CI: ‐$21.62, −$0.75]; p < 0.05), and no change in office and outpatient visits, ED visits, antibiotics filled, or standardized medical spending. Sinusitis episodes with coverage for DTC telemedicine had fewer antibiotics filled (−0.08 [95% CI: −0.14, −0.01]; p < 0.05) and a very small increase in ED visits (0.001 [95% CI: 0.001, 0.010]; p < 0.05), but no change in lab tests, office and outpatient visits, or standardized medical spending.ConclusionsAmong commercially insured patients, coverage of DTC telemedicine was associated with reductions in antibiotics for sinusitis and laboratory tests for UTI without changes in downstream total office and outpatient visits or changes in ED visits.
Risk factors and outcomes of early infection in liver transplant recipients with acute‐on‐chronic liver failure
Authors: Qian Yong Bing , Chen Fang , Hang Hua Lian , Shen Chuan , Han Long Zhi , Deng Yu Xiao , Xia Lei , Zhang Jian Jun , Xia Qiang 
Published: January 2023

ObjectivesPatients with acute‐on‐chronic liver failure (ACLF) have a high risk of infection after liver transplantation (LT). In this study, we aimed to evaluate the prevalence of early post‐LT infection (within one month after LT) in recipients with ACLF, and to compare the survival rate between patients with or without post‐LT infection.MethodsPatients with ACLF who underwent LT between January 2015 and December 2017 were retrospectively included. Characteristics of the patients, prevalence, site and pathogen of post‐LT infection, and its risk factors were evaluated.ResultsA total of 62 patients with ACLF developed bacterial or fungal infection after LT. The 30‐day, 90‐day, and 1‐year survival rates in the infected group were found to be significantly lower than those in the non‐infected group (67.7% vs 98.5%, 64.5% vs 97.7%, and 48.4% vs 95.4%; all P  < 0.001). The most common pathogens involved were carbapenem‐resistant gram‐negative organisms, including Acinetobacter baumannii, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Acinetobacter lwoffi. Multivariate analysis demonstrated that reoperation and length of intensive care unit stay were independently associated with post‐LT infection. In addition, living donor LT and early allograft dysfunction were independently associated with 30‐day all‐cause mortality, whereas red blood cell transfusion and post‐LT infection were independently associated with all‐cause 30‐day and 90‐day mortality after LT.ConclusionsEarly infection after LT is a major prognostic factor in patients with ACLF. Constant vigilance for the risk factors of early infection after LT is needed for timely diagnosis and prompt intervention.
Allotropy of selenium nanoparticles: Colourful transition, synthesis, and biotechnological applications
Authors: Ruiz‐Fresneda Miguel A. , Staicu Lucian C. , Lazuén‐López Guillermo , Merroun Mohamed L. 
Published: January 2023

AbstractElemental selenium (Se0) nanomaterials undergo allotropic transition from thermodynamically‐unstable to more stable phases. This process is significantly different when Se0 nanoparticles (NPs) are produced via physico‐chemical and biological pathways. While the allotropic transition of physico‐chemically synthesized Se0 is fast (minutes to hours), the biogenic Se0 takes months to complete. The biopolymer layer covering biogenic Se0 NPs might be the main factor controlling this retardation, but this still remains an open question. Phylogenetically‐diverse bacteria reduce selenium oxyanions to red amorphous Se0 allotrope, which has low market value. Then, red Se0 undergoes allotropic transition to trigonal (metallic grey) allotrope, the end product having important industrial applications (e.g. semiconductors, alloys). Is it not yet clear whether biogenic Se0 presents any biological function, or it is mainly a detoxification and respiratory by‐product. The better understanding of this transition would benefit the recovery of Se0 NPs from secondary resources and its targeted utilization with respect to each allotropic stage. This review article presents and critically discusses the main physico‐chemical methods and biosynthetic pathways of Se0 (bio)mineralization. In addition, the article proposes a conceptual model for the resource recovery potential of trigonal selenium nanomaterials in the context of circular economy.