bluuebunny/crossref_metadata_2025_split huggingface dataset:
Legendre scalarization in gravity and cosmology
Authors: Cotsakis Spiros , Mimoso Jose P. , Miritzis John 
Published: May 2023

AbstractWe propose a new formulation of f(R) gravity, dubbed scalarized f(R) gravity, in which the Legendre transform is included as a dynamical term. This leads to a theory with second-order field equations that describes general relativity with a self-interacting scalar field, without requiring the introduction of conformal frames. We demonstrate that the quadratic version of scalarized f(R) gravity reduces to general relativity with a massive scalar field, and we explore its implications for Friedmann cosmology. Our findings suggest that scalarized f(R) gravity may lead to simplified descriptions of cosmological applications, while the proposed formulation could offer a new perspective on the relationship between f(R) gravity and scalar–tensor theories.
Tumor-infiltrating Leukocyte Profiling Defines Three Immune Subtypes of NSCLC with Distinct Signaling Pathways and Genetic Alterations
Authors: Aoki Kazunori , Nishito Yukari , Motoi Noriko , Arai Yasuhito , Hiraoka Nobuyoshi , Shibata Tatsuhiro , Sonobe Yukiko , Kayukawa Yoko , Hashimoto Eri , Takahashi Mina , Fujii Etsuko , Nishizawa Takashi , Fukuda Hironori , Ohashi Kana , Arai Kosuke , Mizoguchi Yukihiro , Yoshida Yukihiro , Watanabe Shun-ichi , Yamashita Makiko , Kitano Shigehisa , Sakamoto Hiromi , Nagata Yuki , Mitsumori Risa , Ozaki Kouichi , Niida Shumpei , Kanai Yae , Hirayama Akiyoshi , Soga Tomoyoshi , Maruyama Toru , Tsukada Keisuke , Yabuki Nami , Shimada Mei , Kitazawa Takehisa , Natori Osamu , Sawada Noriaki , Kato Atsuhiko , Yoshida Teruhiko , Yasuda Kazuki , Mizuno Hideaki , Tsunoda Hiroyuki , Ochiai Atsushi 
Published: May 2023

Resistance to immune checkpoint blockade remains challenging in patients with non–small cell lung cancer (NSCLC). Tumor-infiltrating leukocyte (TIL) quantity, composition, and activation status profoundly influence responsiveness to cancer immunotherapy. This study examined the immune landscape in the NSCLC tumor microenvironment by analyzing TIL profiles of 281 fresh resected NSCLC tissues. Unsupervised clustering based on numbers and percentages of 30 TIL types classified adenocarcinoma (LUAD) and squamous cell carcinoma (LUSQ) into the cold, myeloid cell–dominant, and CD8+ T cell–dominant subtypes. These were significantly correlated with patient prognosis; the myeloid cell subtype had worse outcomes than the others. Integrated genomic and transcriptomic analyses, including RNA sequencing, whole-exome sequencing, T-cell receptor repertoire, and metabolomics of tumor tissue, revealed that immune reaction–related signaling pathways were inactivated, while the glycolysis and K-ras signaling pathways activated in LUAD and LUSQ myeloid cell subtypes. Cases with ALK and ROS1 fusion genes were enriched in the LUAD myeloid subtype, and the frequency of TERT copy-number variations was higher in LUSQ myeloid subtype than in the others. These classifications of NSCLC based on TIL status may be useful for developing personalized immune therapies for NSCLC.

Significance:
The precise TIL profiling classified NSCLC into novel three immune subtypes that correlates with patient outcome, identifying subtype-specific molecular pathways and genomic alterations that should play important roles in constructing subtype-specific immune tumor microenvironments. These classifications of NSCLC based on TIL status are useful for developing personalized immune therapies for NSCLC.
A Macaronic Hebrew-Greek-Turkish Poem from the First Printed Karaite Prayerbook, Venice 1528
Authors: Shapira Dan , Vinogradov Andrey 
Published: May 2023

Abstract
In this short article we publish, with translations, a macaronic Hebrew cum Middle Greek religious poem, accompanied by a refrain in Ottoman Turkish, all written in Hebrew characters and fully vocalized. The text comes from a Karaite prayerbook printed in Venice in 1528 on behalf of the Constantinople Karaite community. This poem and its origins played a role in different manipulations of Karaite identities and history during the 19th and 20th centuries.
Narrating Economic History and the History of Economic Thought in Urdu
Authors: Siddiqui Osama 
Published: May 2023

Abstract
Muḥammad Ilyās Barnī’s (1890–1959) ʿIlm ul-Maʿīshat (The Principles of Economics) is an economics textbook that was published in Aligarh in 1917 and claimed to be the first book of economics in Urdu. In the chapter selected for translation here, Barnī narrates the history of India’s trade relationship with Europe, showing how European colonialism exploited Indian industry and gradually placed it in a position of economic subordination. The accompanying introduction to the translation provides a brief overview of Barnī’s life and works, placing the book in the context of his writings on Islam, ethics, and economics. It also situates the book in the larger context of Indian economic thought in the late nineteenth and early twentieth centuries, particularly within debates on poverty, protectionism, and Indian trade. Ultimately, the introduction argues that the study of economic thought and economic history in Urdu reveals a key facet of early twentieth-century language politics in India by highlighting the project of making Urdu a language of social scientific modernity, while also pointing to the development of a vernacular economic critique of empire that became increasingly influential in colonial politics at the turn of the century.
Democratic Peace beyond Westphalia: Kang and Kant
Authors: Hutton Ferris Daniel 
Published: May 2023

Abstract
This piece brings into dialogue two philosophically profound and hugely influential texts on the nature and requisites of international peace: Immanuel Kant’s “Towards Perpetual Peace” (zum Ewigen Frieden) and Kang Youwei’s 康有为 Book of Great Unity 大同书. Both texts articulate bold visions of a world without international war and embed concrete institutional plans for establishing peace within strongly progressivist philosophies of history. But Kang and Kant disagree in some crucial respects. Most significantly: whilst Kant imagines a liberal peace between sovereign states, Kang argues that enduring pacification would have to be enforced by a communitarian and deliberative democratic polity spanning the earth. Reading the Book of Great Unity alongside “Perpetual Peace” raises timely and challenging questions for contemporary Kantians and, more generally, for liberal internationalist political theorists and scholars of international relations.
Tropical Indian Ocean Mixed Layer Bias in CMIP6 CGCMs Primarily Attributed to the AGCM Surface Wind Bias
Authors: Feng Jie , Lian Tao , Chen Dake 
Published: May 2023

Abstract
The relatively weak sea surface temperature bias in the tropical Indian Ocean (TIO) simulated in the coupled general circulation model (CGCM) from the recently released CMIP6 has been found to be important in model simulations of regional and global climate. However, the cause of the bias is debated because the bias is strongly model dependent and shows marked seasonality. In this study, we separate the bias in CGCMs into bias arising from oceanic GCMs (OGCMs) and bias that is independent of OGCMs using a set of CMIP6 and OMIP6 models. We found that OGCMs contribute little to mixed layer bias in the CGCMs. The OGCM-independent bias exhibits a large-scale cold mixed layer bias in the TIO throughout the year, with an unexpectedly high degree of model consistency. By conducting a set of OGCM experiments, we show that the OGCM-independent mixed layer bias is caused mainly by surface wind bias in the utilized CGCMs. About 89% of surface wind bias in the CGCMs is due to the inability of atmospheric GCMs (AGCMs), whereas atmosphere–ocean coupling in the CGCMs has only a minor influence on surface wind bias. The bias in surface wind is also found to be the cause of subsurface temperature bias besides the ocean dynamics such as vertical mixing and vertical shear in currents. Our results indicate that correcting TIO mixed layer bias in CGCMs requires improvement in the capability of AGCM in simulating the climatological surface winds.

Significance Statement
We aimed to discover the cause of temperature bias in the Indian Ocean in CMIP6 models. The bias was separated into oceanic model and ocean-model-independent bias to correspond exactly to bias caused by the oceanic model and by the atmospheric model and coupling, respectively. Oceanic bias contributes little to bias in CMIP6, but ocean-model-independent bias explains the CMIP6 bias throughout the year. We ran oceanic model experiments to show that surface wind bias causes ocean-model-independent temperature bias in the entire TIO and subsurface temperature bias in some areas of the Indian Ocean. We further found that 89% of surface wind bias originates from the atmospheric model. The results improve our understanding of the cause of the bias in the Indian Ocean and show that our method of bias separation is effective for attributing the source of bias to different proposed mechanisms.
Field Measures Are All You Need: Predicting Need for Surgery in Elderly Ground-Level Fall Patients via Machine Learning
Authors: Shooshani Tara , Pooladzandi Omead , Nguyen Andrew , Shipley Jonathan H. , Harris Mark H. , Hovis Gabrielle E. A. , Barrios Cristobal 
Published: May 2023

Background As ground-level falls (GLFs) are a significant cause of mortality in elderly patients, field triage plays an essential role in patient outcomes. This research investigates how machine learning algorithms can supplement traditional t-tests to recognize statistically significant patterns in medical data and to aid clinical guidelines. Methods This is a retrospective study using data from 715 GLF patients over 75 years old. We first calculated P-values for each recorded factor to determine the factor’s significance in contributing to a need for surgery ( P < .05 is significant). We then utilized the XGBoost machine learning method to rank contributing factors. We applied SHapley Additive exPlanations (SHAP) values to interpret the feature importance and provide clinical guidance via decision trees. Results The three most significant P-values when comparing patients with and without surgery are as follows: Glasgow Coma Scale (GCS) ( P < .001), no comorbidities ( P < .001), and transfer-in ( P = .019). The XGBoost algorithm determined that GCS and systolic blood pressure contribute most strongly. The prediction accuracy of these XGBoost results based on the test/train split was 90.3%. Discussion When compared to P-values, XGBoost provides more robust, detailed results regarding the factors that suggest a need for surgery. This demonstrates the clinical applicability of machine learning algorithms. Paramedics can use resulting decision trees to inform medical decision-making in real time. XGBoost’s generalizability power increases with more data and can be tuned to prospectively assist individual hospitals.
Financial Inclusion and Financial Condition: The Mediating Effect of Financial Self-efficacy and Financial Literacy
Authors: Bojuwon Mustapha , Olaleye Banji Rildwan , Ojebode Aderemi Abayomi 
Published: May 2023

Background: The belief of individuals and access to useful, affordable financial resources by small and medium businesses, especially to manage their finances to improve their financial condition, is limited. Objectives: This study investigates the impact of financial inclusion on the financial condition of small and medium enterprises in south-west Nigeria through financial self-efficacy and financial literacy. Methods/Approach: This study employs the purposive sampling technique to employ a quantitative method on the active population of registered small and medium-scale enterprises (SMEs). Two statistical software were used; statistical package for social sciences and structural equation modelling to test the mediating effect of financial self-efficacy and financial literacy on relationship between financial inclusion and financial capability of SMEs. Results: The component effectively measures all its constructs with the confirmatory factor analysis measure. Based on the structural model, financial inclusion directly and indirectly through financial self-efficacy and financial literacy positively influences financial capability. Conclusion: This shows that financial inclusion amplifies the financial condition of SMEs in south-west part of Nigeria. It was recommended that managers of the firms should encourage and implement suitable and appropriate financial inclusion strategies to enhance financial conditions. Likewise, management of the SMEs when making decision on the product and service offered should strategically create thoughtful ideals that will increase their ability to manage their financial condition through financial self-efficacy and literacy. However, it was suggested that similar studies be conducted in other sectors of the economy.
Endometriosis and Depression: A Double Agony for Women
Authors: Chandel Payal Kanwar , Maurya Pawan Kumar , Hussain Sajad , Vashistha Divya , Sharma Shreya 
Published: May 2023

Background Endometriosis is defined as a condition in which a formation of abnormal endometrial tissue outside the uterus takes place. Irrespective of any ethnic and socioeconomic class, the prevalence of the diseases has been seen among women of reproductive age. Endometriosis has been seen adversely affect the physical, psychological, social, and career of women. Summary This paper aims to identify and describe the experiences and outcomes of endometriosis healthcare by reviewing the existing literature on social and psychological effects of endometriosis. The study serves the purpose of providing insights on women’s dual suffering (mental and social health) and critical comments on the present state of knowledge in order to make future recommendations for psycho-social research. The review included systematic search of the articles from various disciplines like, biology, psychology, sociology, anthropology, etc. A structured process of screening with specific inclusion and exclusion criteria was used to select the articles. The analysis of the articles resulted that woman diagnosed with endometriosis reported poor quality of life and the following symptoms such as anxiety, stress, Chronic Pelvic Pain (CPP), anxiety, dyspareunia, and dysmenorrhea. However, depression appears prominent among women diagnosed with endometriosis. There are few strategies mentioned that can be used to deal with endometriosis. Key Message The most promising causes of endometriosis include abnormality in immune functioning, atypical endometriotic growth, genetics, epigenetic, embryogenetic theory, and endocrine disruptors. The ill effects have been noted in the following domains of women’s life such as work, close relationships, social well-being, and education, deteriorating their quality-of-life manifold. Psychological intervention is required to deal with the disorder as only medical treatment with pain may not be sufficient. Though, the condition can be improved by providing awareness regarding the severity of the disorder at the school and community levels.
Outcome of Continuous Positive Airway Pressure (CPAP) Administration in Delivery Room for Neonates with ≧35 Weeks of Gestational Age with Respiratory Distress: A Randomized Control Trial in a Tertiary Care Hospital
Authors: Marathe Tanmay , Bhandankar Manisha 
Published: May 2023

The sixth edition of Neonatal Resuscitation program (NRP 2011) recommends the use of delivery room Continuous Positive Airway Pressure (DR CPAP) for neonates with respiratory distress in the delivery room irrespective of gestational age. However, there is no convincing evidence of benefit of DR CPAP amongst late preterm and term neonates. Methodology This single center, open label, randomized control trial was carried out in a tertiary care teaching hospital. Neonates delivered with GA ≧ 35 weeks developing labored breathing in the delivery room or requiring free flow oxygen to maintain SPO2 in target range were randomized to receive DR CPAP or free flow oxygen (DR FFO). The early neonatal outcome in the DR, and for those requiring NICU admission, was recorded. Results 131 neonates were enrolled in the study, 62 (47.32 %) neonates were randomized to DR CPAP while 69 (52.67 %) to DR FFO group. There was no statistically significant difference observed among neonates from both groups who improved in the DR ( P value:.55) or those shifted to NICU in view of respiratory distress ( P value:.54). There was no significant difference in the modified Downes score amongst 2 groups at the time of NICU admission ( P value:.39). Conclusion This randomized control trial showed no significant difference in the delivery room or early neonatal outcome after the administration of DR CPAP or FFO amongst neonates with gestational age ≧ 35 weeks presenting with respiratory distress. Robust evidence needs to be generated to support the current recommendation of administering DR CPAP irrespective of gestation age.
A Prospective Cohort Study on Spectrum of Community Acquired Late Onset Neonatal Pneumonia: An Eye Opener for Neonatal Care
Authors: Munian Dinesh , Roy Oishik , Poddar Sumon , Hazra Avijit , Ray Somosri 
Published: May 2023

Background Acute lower respiratory tract infections (ALRTIs) are a leading cause of morbidity and mortality in infants in low- and middle-income countries. We emphasize the differences in presentation and outcome between viral and bacterial origin community acquired ALRTI in late neonatal period. Methods All consecutively admitted neonates, aged 7 days or older, with features of ALRTI were included in the study, other than babies referred with prior hospital stay, congenital airway malformations and heart disease. Relevant investigations including nasopharyngeal swab polymerase chain reaction (PCR) and blood culture were done for etiological diagnosis. The predisposing factors, presenting features and short-term outcomes were compared between viral and bacterial etiology cohorts. Results Half of the 89 babies had primary viral infections, respiratory syncytial virus (RSV) being predominant (n = 21, 23.6%); 27 (30.3%) had bacterial infections, while no organisms were identified in 18% cases. Ten babies (11.2%) had COVID-19 and 4 (4.5%) had pertussis. Small for date (n = 15, 55.5%, p < .001) and history of past sick neonatal care unit admission were significantly higher (n = 20, 74.1%, p = .009) in babies with bacterial isolates. Median age of presentation was day 10 (interquartile range [IQR] 8-12). Bacterial ALRTI was more severe with significantly high respiratory score ( p < .001), need for invasive ventilation ( p < .001), systemic complications, and mortality ( p = .012), while viral ALRTI group required longer respiratory support and hospital stay ( p < .001). Conclusions PCR based methods are important in etiological diagnosis of community acquired late onset neonatal pneumonia. Such ALRTI is mostly of viral origin, and this is less likely to be fatal but require longer hospital stay than bacterial pneumonia.
Retinal blood flow velocities in infants with retinopathy of prematurity after intravitreal administration of bevacizumab
Authors: Mohr Franziska H , Fischer Hendrik S , Czernik Christoph , Müller Bert , Bührer Christoph 
Published: May 2023

Background/Objectives Progression of retinopathy of prematurity (ROP) is associated with increased retinal blood flow velocities. We investigated changes of central retinal arterial and venous blood flow after intravitreal administration of bevacizumab. Subjects/Methods Prospective observational study using serial ultrasound Doppler imaging in preterm infants with bevacizumab-treated ROP. Eyes were examined 1 [0–2] days before injection (median [interquartile range]), and at three time points after injection (1 [1–2] days, 6 [3–8] days, and 17 [9–28] days). Preterm infants with ROP stage 2 displaying spontaneous regression served as controls. Results In 21 eyes of 12 infants with bevacizumab-treated ROP, peak arterial systolic velocity declined from 13.6 [11.0-16.3] cm/s prior to intravitreal bevacizumab to 11.2 [9.4–13.9] cm/s, 10.6 [9.2–13.3] cm/s and 9.3 [8.2–11.0] cm/s at discharge ( p  =  .002). There was also a decline of the arterial velocity time integral (from 3.1 [2.3–3.9] cm to 2.9 [2.4–3.5], 2.7 [2.3–3.2] cm and 2.2 [2.0–2.7], p  =  .021) and mean velocity in the central retinal vein (from 4.5 [3.6–5.8] cm/s to 3.7 [2.6–4.1] cm/s, 3.5 [3.0–4.3] cm/s, and 3.2 [2.8–4.6] cm/s, p  =  .012). Arterial end-diastolic velocity and resistance index remained unchanged. Blood flow velocities in bevacizumab-treated eyes examined before injection were significantly higher than those measured in untreated eyes that ultimately showed spontaneous regression of ROP. Sequential examinations in these controls did not reveal any declines of retinal blood flow velocities. Conclusion Increased retinal arterial and venous blood flow velocities in infants with threshold ROP decline following intravitreal bevacizumab injection.
Comparison of MRI T2-lesion evolution in pediatric MOGAD, NMOSD, and MS
Authors: Redenbaugh Vyanka , Chia Nicholas H , Cacciaguerra Laura , McCombe Jennifer A , Tillema Jan-Mendelt , Chen John J , Lopez Chiriboga A Sebastian , Sechi Elia , Hacohen Yael , Pittock Sean J , Flanagan Eoin P 
Published: May 2023

Background: Magnetic resonance imaging (MRI) T2-lesions resolve more often in myelin oligodendrocyte glycoprotein (MOG) antibody-associated disease (MOGAD) than aquaporin-4 IgG-positive neuromyelitis optica spectrum disorder (AQP4 + NMOSD) and multiple sclerosis (MS) in adults but few studies analyzed children. Objective: The main objective of this study is to investigate MRI T2-lesion evolution in pediatric MOGAD, AQP4 + NMOSD, and MS. Methods: Inclusion criteria were as follows: (1) first clinical attack; (2) abnormal MRI (⩽6 weeks); (3) follow-up MRI beyond 6 months without relapses in that region; and (4) age < 18 years. An index T2-lesion (symptomatic/largest) was identified, and T2-lesion resolution or persistence on follow-up MRI was determined. Results: We included 56 patients (MOGAD, 21; AQP4 + NMOSD, 8; MS, 27) with 69 attacks. Index T2-lesion resolution was more frequent in MOGAD (brain 9 of 15 [60%]; spine 8 of 12 [67%]) than AQP4 + NMOSD (brain 1 of 4 [25%]; spine 0 of 7 [0%]) and MS (brain 0 of 18 [0%]; spine 1 of 13 [8%]), p < 0.01. Resolution of all T2-lesions occurred more often in MOGAD (brain 6 of 15 [40%]; spine 7 of 12 [58%]) than AQP4 + NMOSD (brain 1 of 4 [25%]; spine 0 of 7 [0%]), and MS (brain 0 of 18 [0%]; spine 1 of 13 [8%]), p < 0.01. Reductions in median index T2-lesion area were greater in MOGAD (brain, 305 mm; spine, 23 mm) than MS (brain, 42 mm [ p<0.001]; spine, 10 mm [ p<0.001]) without differing from AQP4 + NMOSD (brain, 133 mm [ p=0.42]; spine, 19.5 mm [ p=0.69]). Conclusion: In children, MRI T2-lesions resolved more often in MOGAD than AQP4 + NMOSD and MS which is similar to adults suggesting these differences are related to pathogenesis rather than age.