bluuebunny/crossref_metadata_2025_split huggingface dataset:
Combined treatment is the hope to improve prognosis of liver cancer
Authors: Chen Xiaoping , Zhang Binhao 
Published: June 2023

Xiaoping Chen, Academician of the Chinese Academy of Science, Professor and Chairman of the Department of Surgery, Director of the Institute of Hepato-Pancreato-Biliary Surgery and Hepatic Surgery Center of Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology. He earned his M.D. from Tongji Medical College in 1985 and was further trained in the United States and Germany. In 1992, he received the International Scholar title from the American Cleveland Medical Communication Center. In 1996, he earned the American Sackler Chinese Doctor Annual Award. The next year, he became the first recipient of the Wu Mengchao Hepatobiliary Surgery Foundation Award. In 2002, his study entitled “Series of research and technique amelioration in hepatic surgery” won him the first Chinese Medical Association Award. He was elected the director of the Hepatic Surgery Group of the Chinese Medical Association in 2002 and then president of the Chinese Chapter of the International Hepato-Pancreato-Biliary Association in 2003. His basic and clinical application research on hepatic surgery won him the National Science and Technology Progress Award in 2004.
Dr. Chen has a clinical practice focused on hepato-pancreato-biliary surgery. He cares for patients with a broad spectrum of malignancies, including liver, bile duct, and pancreatic cancers. He also serves as director of the institute of organ transplantation and specializes in clinical liver transplantation. In addition to his clinical practice and administrative responsibilities, Dr. Chen is an active investigator in the field of cancer biology and cancer clinical trials. He has published over 500 peer-reviewed articles in these fields and has had continuous funding from the National Nature Science Foundation of China for more than 10 years.
Dr. Chen is the editor-in-chief of the national medical textbooks Surgery, Contemporary Surgical English Essentials, Elementary Techniques of Surgical Intervention, Surgical Frequently Used Experiment Methods and Foundation of Animal Models, Hepatectomy, and Progress of Hepato-pancreatobiliary and Splenic Surgery. He is also the editor-in-chief, associate editor, and/or reviewer for more than 30 domestic and international journals.
Three-dimensional conformal radiotherapy plus concurrent DICE chemotherapy for early-stage nasal-type natural killer/T-cell lymphoma of Waldeyer’s ring: A single-institution study ⁎
Authors: Zhou Ji , Ma Daiyuan , Zhou Yeqin , Li Xianfu , Tan Bangxian , Liu Mi , Ren Tao 
Published: June 2023

AbstractObjectiveNasal-type natural killer/T-cell lymphoma of Waldeyer’s ring (WR-NK/TL) has different clinicopathological characteristics from those of other subtypes of NK/T lymphoma; thus, the optimal treatment remains unclear. To find a more effective treatment model for WR-NK/TL, we conducted a single-center study of concurrent radiochemotherapy.MethodsForty-five patients with newly diagnosed stage IE to IIE WR-NKTL were randomly divided into two groups. The 23 cases in the concurrent radiochemotherapy group were treated with three-dimensional conformal radiotherapy (48-52 Gy) and 2 courses of DICE (dexamethasone, ifosfamide, cisplatin, and etoposide) synchronous chemotherapy. The 22 cases in the radiotherapy group only received three-dimensional conformal radiotherapy (50-54 Gy). The primary end points were overall survival (OS), progressionfree survival (PFS), and toxicity.ResultsThe 1-, 3-, and 4-year OS and PFS rates were 95.5%, 65.6%, and 45.9%, and 86.4%, 56.0%, and 46.7% in the radiotherapy group, and 100%, 88.5%, and 88.5%, and 100%, 82.0%, and 73.8% in the concurrent radiochemotherapy group, respectively. The OS (P= 0.0477) and PFS rates (P= 0.0488) were higher in the concurrent radiochemotherapy group than in the radiotherapy group. The overall response rate was 100% in both the radiotherapy group [complete response (CR), 18 cases] and concurrent radiochemotherapy group (CR, 22 cases). The concurrent radiochemotherapy group had more severe side effects, especially grade 3 + 4 events, such as leukopenia, anorexia, and stomatitis. However, side effects benefiting from excellent oral care were endurable.ConclusionRadiotherapy plus concurrent DICE chemotherapy may be an effective and safe comprehensive treatment for patients with WR-NKTL.
Diagnostic accuracy of real-time tissue elastography for breast cancer: a meta-analysis
Authors: Wang Cong , Yang Guang , Wang Hui 
Published: June 2023

Abstract

Objective
The present study aimed to determine the accuracy of real-time tissue elastography (RTE) for the diagnosis of breast cancer.

Methods
The search was conducted in the PubMed, Web of Science, Cochrane Library, and China Biology Medicine databases from inception through December 31, 2014, without language restrictions. The meta-analysis was conducted using STATA version 12.0 and Meta-Disc version 1.4. We calculated the summary statistics for sensitivity (Sen), specificity (Spe), positive and negative likelihood ratio (LR+/LR-), diagnostic odds ratio (DOR), and summary receiver operating characteristic (SROC) curve.

Results
Ten studies that met all inclusion criteria were included in the meta-analysis. A total of 608 malignant breast lesions and 1292 benign breast tumors were assessed. All breast lesions were histologically confirmed after RTE. The pooled Sen was 0.83 (95% CI = 0.79-0.86); the pooled Spe was 0.86 (95% CI = 0.84-0.88). The pooled LR+ was 9.87 (95% CI = 2.66-36.71); the pooled LR- was 0.20 (95% CI = 0.17-0.23). The pooled DOR of RTE for the diagnosis of breast cancer was 62.21 (95% CI = 33.88-114.24). The area under the SROC curve was 0.9334 (standard error = 0.00125). We found no evidence of publication bias (t = -0.57, P = 0.582).

Conclusion
RTE may have high diagnostic accuracy for the differential diagnosis of benign and malignant breast tumors. RTE may be a good tool for breast cancer diagnosis.
Antiangiogenic agents combined with chemotherapy in non-small cell lung cancer
Authors: Chen Shanshan , Lu Shun 
Published: June 2023

Abstract
As a targeted therapy, antiangiogenic treatment has been increasingly studied for advanced non-small cell lung cancer (NSCLC) and has proven effective for the treatment of advanced NSCLC. Bevacizumab, a monoclonal antibody targeting angiogenesis, is the only antiangiogenic agent approved for use in combination with first-line chemotherapy for non-squamous NSCLC. Small-molecule inhibitors targeting the tyrosine kinase receptor have also shown promise when combined with standard chemotherapeutic agents in patients with advanced NSCLC. However, unlike bevacizumab, not all other antiangiogenic agents show significant benefits when combined with chemotherapy. As for the failures of most other combinations, the combination schedule may be an important reason that has so far been overlooked in clinical trials. This article reviews the combination of angiogenic agents with chemotherapy in the treatment of NSCLC.
A case of primary malignant fibrous histiocytoma of the pancreas with liver metastasis ⁎
Authors: Zhai Wenlong , Ye Jianwen , Liang Zhiwei , Zhou Chuang , Zhao Longshuan 
Published: June 2023

Abstract
Malignant fibrous histiocytoma (MFH) is one of most common types of soft-tissue sarcoma. However, it accounts for less than 1% of all human cancer types. In addition, primary MFH of the pancreas is very rare. Herein, we report of a 37-year-old man who presented with a pancreatic mass and did not show any specific symptoms. Pre-contrast computed tomography (CT) showed a heterogeneous, liquid-filled necrotic mass in the uncinate lobe of the pancreas. Contrast-enhanced CT showed a mild enhancement of solid components and the pancreaticoduodenal artery across the mass. The patient underwent a pancreaticoduodenectomy, ethanol ablation of the liver lesions, and chemotherapy with 4 cycles of ifosfamide and doxorubicin. The tumor recurred in the liver, but not in the pancreas, after 8 months.
Abnormal expression of VEGF and its gene transcription status as diagnostic indicators in patients with non-small cell lung cancer ⁎
Authors: Shi Yun , Shi Yang , Yang Xuli , Chen Jianrong , Qian Qi , Yao Dengfu , Wu Guangzhou 
Published: June 2023

Abstract

Objective
Angiogenesis is known to be essential for the survival, growth, invasion, and metastasis of lung cancer cells. Vascular endothelial growth factor (VEGF) is an important factor regulating angiogenesis of non-small cell lung cancer (NSCLC); however, its pathologic features and significance are unclear. In this study, the tissue VEGF expression levels and its gene transcriptional status, as well as circulating VEGF levels, were investigated in patients with lung disease.

Methods
VEGF protein and mRNA expression levels in 38 lung tissue samples were analyzed by immunohistochemistry and reverse transcription-polymerase chain reaction (RT-PCR), respectively. Circulating VEGF levels were detected quantitatively by an enzyme linked immuno-sorbent assay.

Results
The level of VEGF expression was significantly higher in lung cancer tissue than in the corresponding paracancerous or non-cancerous tissues. The average level of VEGF-positive staining was 76% in tissue samples from NSCLC patients; the levels were 89% in tissue samples from stage III patients and 92% in stage IV patients. High VEGF expression was also evident in cases with lymph node metastasis (84%), distant metastasis (90%), and lower differentiation degree (89%). VEGF mRNA in cancerous tissues was represented predominantly by the VEGF121 and VEGF165 isoforms. Circulating VEGF levels were significantly higher in NSCLC patients [(840 ± 324) pg/mL] than in patients with benign lung diseases [(308 ± 96) pg/mL] or in healthy individuals serving as controls [(252 ± 108) pg/mL].

Conclusion
The over-expression of lung VEGF and its gene transcription status should be useful molecular indicators for NSCLC diagnosis.
Role of inflammatory gene variants in Helicobacter pylori-related gastric cancer ⁎
Authors: Li Miao , Li Jun , Qi Zhaozhen , Tang Qiu , Wang Xiangyang , Lu Hongda 
Published: June 2023

Abstract

Helicobacter pylori-related gastric cancer results from a chronic inflammatory process that arises from atrophic gastritis, and develops into intestinal metaplasia, hyperplasia, and eventually gastric adenocarcinoma. Although approximately half of the world’s population is infected with Helicobacter pylori (H. pylori), less than 3% of these infected individuals develop gastric cancer. H. pylori infection can cause both acute and chronic inflammation, and may be present for decades within its host. Inflammatory gene variants are particularly important factors that may influence a host’s susceptibility to H. pylori-related gastric cancer. The inflammatory gene variants uncovered thus far include interleukin gene clusters, tumor necrosis factor-α, Toll-like receptors (TLRs), and inflammatory gene polymorphisms found in genome-wide association studies (GWAS). The association between these gene variants and the risk of H. pylori-related gastric cancer will aid in our understanding of the pathogenesis of gastric cancer in order to prevent and defeat this malignancy.
Progress in research on digestive system oncology
Authors: Yuan Xianglin 
Published: June 2023

Xianglin Yuan,
Professor of Oncology, Doctoral Supervisor, Deputy Director of the Oncology Department and Director of the Digestive System Oncology Department, Tongji Hospital, Tongji Medical College of HUST, China. Yuan discovered that CT/CC genotypes of the TGFbeta1 rs1982073: T869C gene were associated with a low risk of radiation pneumonitis (RP) in patients with non-small cell lung cancer (NSCLC) treated with definitive radio(chemo)therapy and thus might serve as a reliable predictor of RP (Journal of Clinical Oncology, 2009; cited over 70 times). He indicated that genetic variations in PI3K-AKT-mTOR could predict brain metastasis in patients with NSCLC (Journal of Clinical Cancer Research, 2014). He also discovered that among the candidate genes involved in the TGF-β pathway, polymorphisms of SMAD3 appeared to be highly predictive of outcome in patients with lung adenocarcinoma after gefitinib treatment, especially in those with epidermal growth factor receptor mutations (Annals of Oncology, 2014). He has published about 30 articles found in the Science Citation Index (SCI) and has managed 3 items of the National Natural Science Foundation of China. He is an expert in radiation therapy and comprehensive therapy for common malignant tumors such as esophageal, gastric, liver, colorectal, and lung cancers. He now holds the following responsible positions: Chairman, Oncology Committee, Wuhan Medical Association; Chairman, Committee of Molecular Marker and Translational Medicine, Hubei Anti-Cancer Association; Vice Chairman, Committee of Radiation Therapy, Hubei Anti-Cancer Association; Member, Executive Committee, Chinese Society of Clinical Oncology; member, Committee of Tumor Marker, Chinese Anti-Cancer Association.
Advances in the diagnosis and treatment of IgG4-related sclerosing cholangitis: a review
Authors: Du Shunda , Liu Gang , Mao Yilei 
Published: June 2023

Abstract
Immunoglobulin G4-related sclerosing cholangitis (IgG4-SC) is an IgG4-related disease characterized by bile duct fibroinflammatory wall-thickening and stenosis, resulting in obstruction jaundice, weight loss. Different regions of the bile duct can be involved, with the distal region being the most common. IgG4-SC can also have other organ involvement, such as the pancreas, urinary tract, salivary glands and lacrimal glands. In clinical practice, the manifestation of IgG4-SC is very similar to cholangiocarcinoma (CC) and primary sclerosing cholangitis (PSC), as well as pancreatic malignancies, while the treatment and prognosis are totally different. Japanese researchers ever established the clinical diagnostic criteria in 2012: (1) characteristic biliary imaging findings; (2) elevated serum IgG4 concentrations; (3) the coexistence of IgG4-related diseases except those of the biliary tract; and (4) characteristic histopathological features. According to our observations, IgG4-SC can be distinguished from CC with 100% specificity only at a cutoff of six times the upper normal limit. Imaging findings have low specificity for diagnosis, with the exception of intraductal ultrasonography, which can reflect the lesion with relatively high specificity. IgG4 plasma cell infiltration can be found in bile duct biopsy tissue, although this procedure is difficult. According to recent studies, the treatment of IgG4-SC relies mainly on corticosteroids. Following steroid treatment, most IgG4-SC patients can recover and their symptoms are resolved although a few patients relapse after steroid withdrawal. Maintenance of steroid therapy or alternative drugs is necessary in such cases. There is, however, no strong evidence for malignant transformation in IgG4-SC.
New era, new concept, new idea
Authors: Hu Daoyu 
Published: June 2023

Daoyu Hu,
Professor of Radiology, Doctoral Supervisor, director of the Radiology Department in Tongji Hospital, Tongji Medical College of HUST, China. Prof. Hu studied in Germany as a visiting professor for 3 years. He has worked on the diagnosis of abdominal radiology and interventional radiology for over 30 years. He is an expert in diagnosing digestive, genitourinary and vascular disease by using various medical imaging methods such as CT, MRI and interventional radiology. He now holds the following responsible positions: Chairman, Radiology Committee, Hubei Medical Association; Vice chairman, Abdominal Committee of Chinese society of Radiology; Member, Chinese Society of Radiology; Editorial board member, Chinese Journal of Radiology; Chief editor, Radiologic Practice.
Non-specific histological variant of dysembryoplastic neuroepithelial tumor: a diagnostic challenge
Authors: Chen Yanyang , Li Bin , Luo Boning , Tian Xiaoying , Li Zhi 
Published: June 2023

Abstract

Objective
The accurate diagnosis of the non-specific variant of dysembryoplastic neuroepithelial tumor (DNT) is very difficult because it is characterized by absence of the histological hallmark of the “specific glioneuronal element” in lesions. We herein present two cases of the non-specific form of DNT to analyze the clinical, radiological, and histological features of this unusual subtype of DNT.

Methods
A 16-year-old and a 23-year-old patient had been treated for pharmacoresistant epilepsy for several years before undergoing referral to the hospital for further examination and treatment. Magnetic resonance imaging (MRI) revealed that both patients had a small, well-demarcated cystic lesion within the cortex of the brain without obvious contrast enhancement or peritumoral edema. The lesions were totally resected and routinely examined using histological and immunohistochemical analysis.

Results
Both lesions exhibited similar histological appearances with cyst formation and mural nodule architecture. The glial nodules were mainly composed of oligodendrocyte-like components, and partly of piloid cells resembling pilocytic astrocytoma. The cortex adjacent to the lesion in both cases was found to have the histological features of focal cortical dysplasia (FCD) Type I. Immunohistochemically, the oligodendrocyte-like components were diffusely positive for Syn and Olig-2, but staining for CD34, p53, and IDH1 R132H was negative. The Ki-67 (MIB-1) labeling index was low, approximately 1%. There was no 1p/19q co-deletion in either lesion by fluorescence in situ hybridization (FISH) assay. Neither patient received postoperative adjuvant treatment, and both underwent regular follow-up for at least 24 months. No signs of recurrence or epileptic attacks were observed during the follow-up period.

Conclusion
The non-specific variant of DNT is a diagnostic challenge for pathologists in clinical practice, and differentiation from some low-grade gliomas needs to be considered. The careful inspection of radiologic and histopathologic findings, accompanied by analysis of patients’ clinical manifestations, may be helpful in making an accurate diagnosis.
Fibroblastic reticular cell sarcoma of the small intestine: a very rare case report and clinicopathological diagnosis
Authors: Zhong Dingrong , Wu Dong 
Published: June 2023

Abstract
A 54-year-old man was admitted for the evaluation of fever and abodominal pain. Radiological and endoscopic examination revealed a lung nodule and multiple small intestine uclers. Clinical diagnosis such as tuberculosis and Crohn’s disease had been proposed. He developed intestine perforation after small bowel endoscopic procedure. During emergent surgery the involved intestinal segments were resected and a pathological diagnosis of fibroblastic histiocytic sarcoma (FBRC) was made. The patient died in the sixth month after the operation. The management of this cases highlighted the drawback of pattern recognition as the most commonly used clinical reasoning method, and the importance of histological investigation.
Single-stage en bloc resection using a posterior approach for sacral tumors
Authors: Fang Zhong , Wu Wei , Xiong Wei , Li Guanghui , Liao Hui , Xiao Jun , Guo Fengjing , Chen Anmin , Li Feng 
Published: June 2023

Abstract

Objective
This study aims to investigate the surgical results of single-stage en bloc resections using a posterior approach for sacral tumors and evaluate its benefit for these tumors.

Methods
A total of 32 cases involving patients with sacral tumors who were treated with single-stage en bloc resection by posterior approach from April 2004 to January 2010 were reviewed. The patient cohort included 20 males and 12 females. The average patient age was 49.1 years old (range, 18 to 75 years old). Twenty-seven patients suffered from primary sacral tumors, including 17 patients with chordomas, 5 patients with giant cell tumors of the bone, 3 patients with chondrosarcoma, 1 patient with sarcoma of the nerve fibers, and 1 patient with neurofibromatosis. Five patients were diagnosed with sacral metastatic tumors, including 2 cases of breast cancer, 1 case of renal carcinoma, 1 case of thyroid cancer, and 1 case of lung cancer. According to the Frankel grading system, there were 3 Grade B tumors, 4 Grade C tumors, 10 Grade D tumors, and 15 Grade E tumors.

Results
The operation took 265 min on average (range, 130-360 min), and blood loss was 1676 mL on average (range, 800-1800 mL) during the operation. The follow-up period ranged from 6 months to 6.2 years. All patients had pain prior to operation. Twenty-eight patients experienced complete pain-relief, and 4 patients experienced partial pain-relief after their operations. In all patients, neurological function was improved more than one grade using the Frankel grading system. Up to now, 5 patients experienced local recurrence after operation, and 2 patients were deceased. The remaining patients are still alive without recurrence.

Conclusion
Single-stage en bloc resection through a posterior approach for sacral tumors is feasible, safe, and effective. It has many advantages, such as controlling local recurrence, thorough decompression of the spinal cord, relieving pain, improving quality of life, and prolonging survival.
Evaluation of photon beam dose calculation accuracy of treatment planning systems using in vivo dosimetry
Authors: Ibrahim Mohamed , Attia Wahib M. , Elshahat Khaled M. 
Published: June 2023

Abstract

Objective
The treatment planning system currently represents one of the basics of radiation therapy, because it is the only method to estimate patient dose delivery fast forward and accurately represent estimated tumor location of the tumor with the possibility of estimating densities in the tissue surrounding the tumor to overcome dose calculation defects but radial estimated the patient. Despite the flaws associated with the systems and calculates the dose of your programs in all programs currently existing in the world. Than necessary, to the existence of a review of the accuracy of accounts and how to confirm the radiation dose to the patient programs.

Methods
A total of 35 cancer patients were considered for this study, with 245 field measurements made with low- and high-energy diode detectors for brain and prostate cases. The treatments for all patients were planned using Eclipse Treatment Planning System version 13.6.

Results
Of the 105 field measurements made for the prostate cancer patients, 16 included discrepancies outside the ±5% action level. Of the 145 measurements taken of the brain cases, there were four outside the ±5% action level. The results indicated a higher degree of accuracy. The study revealed that, for the prostate measurements, the higher discrepancy in the doses for the particular fields (exceeding the action level) may have been due to the isocenter being very close to the jaws and multi-leaf collimator of the linear accelerator machine. As a result, scatter from the jaws and the multi-leaf collimator could have contributed to the high dose delivered to the diode; hence, a probable higher discrepancy of the dose in more brain cases due highest quality of VMAT technique and fixation system.

Conclusion
A greater percentage of the observed discrepancies were well within the set tolerance level. However, it is recommended that the positioning of the diode on the patient’s skin and the angular sensitivity of the diodes be reconsidered. It is also recommended that a more accurate calculation of expected diode values be performed, especially for fields that pass through the table. These efforts would achieve action levels of ±5%.