bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factors predicting age at menopause among Iranian women in the Bandare-Kong cohort study (a cross-sectional survey of PERSIAN cohort study)
Authors: Kutenaee Maryam Azizi , Dashti Sareh , Rafati Shideh , Moannaei Mehrsa , Masoudi Mojtaba , Nejatizadeh Abdolazim , Shahmoradi Mehdi , Roozbeh Nasibeh 
Published: August 2023

Abstract
Background
Menopause is a natural period in women’s life and can be affected by several factors. The aim of this study was to identify the associated factors for age of natural menopause and among women with early and premature menopause based on a cohort study in Iran.

Methods
This population-based study was conducted on 894 post menopause women between 35 and 70 years old who participated in the Bandare-Kong Non-Communicable Diseases (BKNCD) Cohort Study, a part of Prospective Epidemiological Research Studies in Iran (PERSIAN) from March 2016 to February 2019. All women completed a standard self-reported questionnaire. Data were analyzed using chi-square test, independent t test, and ANOVA as well as a multivariable linear regression model.

Results
The mean age at natural menopause was 48.31 ± 6.34 years. After adjusting other variables, gravida, history of cardiac disease, socioeconomic status and residence status were predictive of age at menopause (P < 0.001). Among the premature menopause group, the mean age at menopause was significantly higher among women with diabetes compared to women without diabetes group (35.68 ± 2.92 vs. 33.82 ± 3.06; P = 0.043), while the mean age at menopause was significantly lower in women with infertility compared to women without infertility (29.13 ± 5.22 vs. 34.84 ± 2.826; P = 0.048).

Conclusions
This study suggests that the predictors of menopausal age differed in women with premature menopause compared to overall menopause age. Prospective studies are needed to evaluation the effects of these factors on menopausal age.
Molecular characterization of enterotoxin genes in methicillin-resistant S. aureus isolated from food poisoning outbreaks in Egypt
Authors: Ramadan Heba A. , El-Baz Ahmed M. , Goda Reham M. , El-Sokkary Mohamed M. A. , El-Morsi Rasha M. 
Published: August 2023

Abstract
Background
Staphylococcus aureus (S. aureus), especially methicillin-resistant S. aureus (MRSA), is a known disease-causing bacteria with many associated health hazards. Staphylococcal food poisoning can result from staphylococcal enterotoxins (SEs).

Methods
In this study, 50 S. aureus isolates were isolated from the gastrointestinal tract (GIT) clinical samples of patients with food poisoning in clinical laboratories at Mansoura University Hospital, Egypt. For determination their antibiogram, these isolates were tested for antimicrobial sensitivity against 12 antimicrobial agents using the agar disk diffusion test. After DNA extraction from the isolates, conventional polymerase chain reaction (PCR) was used to detect mecA and SEs genes.

Results
As a result, all isolates were ampicillin and cefoxitin-resistant, while 86% (43 of 50) of the tested isolates exhibited multidrug resistance (MDR). In contrast, the highest sensitivity was confirmed against vancomycin, linezolid and quinolones, namely ciprofloxacin and norfloxacin. Although 100% of the isolates were mecA positive, staphylococcal enterotoxin genes set-A, set-B, set-C, set-G, set-M, and set-O genes were detected in 56%, 20%, 8%, 32%, 16%, and 24%, of the tested isolates, respectively. Finally, isolates encompassing SEs genes were used to validate a microarray chip, indicating its potential for a better methodological approach for detecting and identifying SEs in human samples.

Conclusion
The genotypic findings of this study may help explain the enterotoxigenic patterns in S. aureus among Egyptian patients with food poisoning.
Long-Term Results of Cortical Motor Stimulation for Neuropathic Peripheral and Central Pain: Real-World Evidence From Two Independent Centers
Authors: Aibar-Durán Juan Ángel , Villalba Martínez Gloria , Freixer-Palau Berta , Araus-Galdós Elena , Morollón Sanchez-Mateos Noemi , Belvis Nieto Robert , Revuelta Rizo Miren , Molet Teixeido Joan , García Sánchez Carmen , de Quintana Schmidt Cristian , Muñoz Hernandez Fernando , Rodríguez Rodríguez Rodrigo 
Published: August 2023

BACKGROUND AND OBJECTIVES:
Cortical motor stimulation (CMS) is used to modulate neuropathic pain. The literature supports its use; however, short follow-up studies might overestimate its real effect. This study brings real-world evidence from two independent centers about CMS methodology and its long-term outcomes.

METHODS:
Patients with chronic refractory neuropathic pain were implanted with CMS. The International Classification of Headache Disorders 3rd Edition was used to classify craniofacial pain and the Douleur Neuropathique en 4 Questions Scale score to explore its neuropathic nature. Demographics and clinical and surgical data were collected. Pain intensity at 6, 12, and 24 months and last follow-up was registered. Numeric rating scale reduction of ≥50% was considered a good response. The Clinical Global Impression of Change scale was used to report patient satisfaction.

RESULTS:
Twelve males (38.7%) and 19 females (61.3%) with a mean age of 55.8 years (±11.9) were analyzed. Nineteen (61.5%) were diagnosed from painful trigeminal neuropathy (PTN), and seven (22.5%) from central poststroke pain. The mean follow-up was 51 months (±23). At 6 months, 42% (13/31) of the patients were responders, all of them being PTN (13/19; 68.4%). At last follow-up, only 35% (11/31) remained responders (11/19 PTN; 58%). At last follow-up, the global Numeric rating scale reduction was 34% (P = .0001). The Clinical Global Impression of Change scale punctuated 2.39 (±0.94) after 3 months from the surgery and 2.95 (±1.32) at last follow-up (P = .0079). Signs of suspicious placebo effect were appreciated in around 40% of the nonresponders.

CONCLUSION:
CMS might show long-term efficacy for neuropathic pain syndromes, with the effect on PTN being more robust in the long term. Multicentric clinical trials are needed to confirm the efficacy of this therapy for this and other conditions.
Bioelectrical Impedance for Accuracy Detecting Body Composition Changes during an Activity Intervention
Authors: Schneider Patrick L. , Bassett David R. , Thompson Dixie L. , Crouter Scott E. 
Published: August 2023

ABSTRACT
Body composition is an important component of an individual's health and fitness profile. The purpose of this study was to assess the accuracy of bioelectrical impedance analysis (BIA) in detecting percent body fat (%BF) changes throughout a physical activity intervention in previously sedentary, overweight men and women. Fourteen men (mean ± SD; 46 ± 7 yr) and 22 women (47 ± 5 yr) with a body mass index of ≥25 kg·m−2 participated in an intervention of 10,000 steps per day for 36 wk. %BF was measured by air displacement plethysmography (ADP; criterion measure) and BIA at baseline, 20 wk, and 36 wk. During the 36-wk intervention, the women lost 1.6 ± 4.8 kg and the men lost 3.9 ± 4.2 kg. There was a significant three-way interaction for %BF across time points, device, and sex (P = 0.019). Among women, ADP and BIA detected %BF changes of −1.9% ± 2.0% and 0.5% ± 1.8%, respectively, from baseline to 20 wk, and −1.5% ± 2.3% and 0.3% ± 2.5%, respectively, from baseline to 36 wk. Among men, ADP and BIA detected %BF changes of −1.9% ± 1.8% and −1.5% ± 1.9%, respectively, from baseline to 20 wk, and −2.8% ± 3.7% and −2.3% ± 2.6%, respectively, from baseline to 36 wk. There was a significant difference in the accuracy of BIA in detecting %BF changes compared with ADP in women but not men on a group level. However, on an individual level, there was greater variation in BIA's accuracy in tracking %BF changes in both sexes. Compared with ADP, BIA is a suitable method for detecting %BF changes in a group of overweight men, but not women. However, caution should be exercised when using BIA to track body composition changes in either sex on an individual level.
As restrições de loteamento e as leis urbanísticas supervenientes
Authors: Meirelles Hely Lopes 
Published: August 2023

1. Loteamento urbano e suas restrições à edificação. 2. As leis urbanísticas como normas de ordem pública. 3. A competência do município em assuntos urbanísticos. 4. O interesse público no uso e ocupação do solo urbano. 5. A prevalência dos novos usos.
Prefeito - Perda de mandato - Ato político - Controle jurisdicional
Authors: Ribeiro Manoel 
Published: August 2023

- A decretação da perda de mandato de Prefeito por Câmara Municipal não é ato jurisdicional, mas politico-administrativo.- No procedimento politico-administrativo, a forma substancial deve ser observada, sob pena de nulidade da dec:são executória.- Interpretação do Decreto-Iei n9 201, de 1967.
Ato administrativo - Licença para obras
Authors: Cotrim Neto Alberto Bittencourt 
Published: August 2023

- O ato administrativo de que resulta uma situação individual não pode ser revogado pela própria administração.- Concedida uma licença para obra, e esta já tendo tido início de execução, não poderá tal licença ser revogada ou anulada senão através de processo judicial específico.
Sociedades de economia mista - Empresas públicas - Fiscalização pelo Tribunal de Contas
Authors: Marques José Frederico 
Published: August 2023

Existe clara distinção na lei entre a fiscalização sobre a administraçãodireta e sobre as autarquias da União, de um lado, e sobre as sociedades de economia mista e empresas públicas de qualquer órgão público da Federação, de outro.- A fiscalização tem de confinar-se ao que dispõe a lei e o direito escrito; o que sair desses limites constituirá arbítrio, desvio ou excesso de poder.- Interpretação do art. 70 da Constituição.- Idem, da Lei nt? 6223 de 1975.
Responsabilidade civil do estado - Atos de terrorismo - Culpa - Risco administrativo
Authors: Wald Arnaldo 
Published: August 2023

- Quando o Estado causa algum dano, por ação ou omissão, deve o mesmo ser reparado, independentemente da prova da culpa.- A pessoa jurídica de direito público só se exonera da responsabilidadecomprovando a força maior, não bastando a prova de simples ausência de culpa dos seus funcionários como entendia a jurisprudência anterior.
Imposto de renda - Lucro de operação e alienação do bem imóvel
Authors: Martins Ives Grandra da Silva 
Published: August 2023

- Os imóveis adquiridos e quitados há mais de cinco anos, incorporadosao ativo da empresa, podem ser alienados, com expressa exclusão do lucro real, desde que a operação seja liquidada em prazo certo e incorporados os seus resultados ao capital social.
As empresas públicas e as sociedades de economia mista, dos estados e dos municípios
Authors: Figueira J. G. de Andrade 
Published: August 2023

Este trabalho tem apenas por objetivo provocar um pronunciamentosobre questão de palpitante interesse, do que poderá resultar sejam alertados os poderes competentes para elaboração de uma legislação especial, indiscutivelmente necessária.
O lançamento tributário e o ato administrativo nulo
Authors: Correa Walter Barbosa 
Published: August 2023

Relação do direito tributário com o administrativo. Ato administrativonulo. Anulação e revogação de ato administrativo. Revisão do lançamentopela administração. Argüição de vício de competência, de procedimento e de forma. Vício material. Conclusão.
Desapropriação - Interesse social - Plano de urbanização
Authors: Mello Celso Antônio Bandeira de 
Published: August 2023

- A desapropriação por interesse social não é privativa da União - os estados e os municípios também podem desapropriar com esse fundamento, com ressalva, unicamente, da hipótese específica do art. 161 da Constituição. - Os estados e os municípios podem desapropriar propriedade rural a fim de nela efetuar, com base no art. 5Q letra i do Decreto-lei nQ 3.365, de 1941, "planos de urbanização" em ordem à constituição de distrito industrial.- A revenda dos bens expropriados e o lucro que daí resulte não são, em si mesmos, causa de vício jurídico.
Ensino superior - Fundação - Autarquia especial
Authors: Tácito Caio 
Published: August 2023

- A opção entre a forma jurídica de fundação ou autarquia especial nas universidades oficiais deve se inspirar, dominantemente,no princípio de garantir a autonomia e a qualidade do ensino superior.- O regime de autarquia especial deverá ser implantado mediantelei própria.- E indiferente, quanto à gratuidade do ensino, a forma autárquicaou fundacional da universidade.
Experimental demonstration of high-Q MRR based on a germanium-on-insulator platform with an yttria insulator in the mid-IR range
Authors: Lim Jinha , Shim Joonsup , Kim Inki , Kim SangHyeon 
Published: August 2023

We experimentally demonstrate an all-pass microring resonator (MRR) based on a Y2O3 BOX germanium-on-insulator (GeOI) platform operating in the mid-IR region. The ring resonator was numerically designed to have a high quality (Q) factor in the 4.18 μm to 4.22 μm wavelength range in the fundamental TE mode. According to our design, the GeOI ring resonator was fabricated by the direct wafer-bonding technology with an yttria (Y2O3) buried oxide layer, which is transparent at the mid-IR region, for the bonding interface and the electron beam lithography. The experimental resonant characteristic was obtained using our fiber-based mid-IR measurement setup. The GeOI single MRR exhibited an extinction ratio (ER) of 15.28 dB and an insertion loss (IL) of 1.204 dB, and the racetrack showed an ER of 22.77 dB and an IL of 0.627 dB. Furthermore, the free spectral range of the device was 5.29 nm, and the loaded Q factor of 94,528 (176,158 of intrinsic Q factor) was extracted by the nonlinear least squares method. We believe this demonstration of our GeOI MRR offers a valuable opportunity to implement multipurpose devices such as optical sensors, switches, and filters in the mid-IR range.
Marketing of medicines in primary care: An analysis of direct marketing mailings and advertisements
Authors: Dankers Marloes , Verlegh Peeter , Weber Karla , Nelissen-Vrancken Marjorie , van Dijk Liset , Mantel-Teeuwisse Aukje 
Published: August 2023

Introduction
Marketing materials from pharmaceutical companies attempt to create a positive image of marketed, often new, medicines. To gain more insight in strategies pharmaceutical companies use to influence primary care practitioners’ attitudes towards marketed medicines, we investigated the use of persuasion strategies in direct marketing mailings and advertisements from pharmaceutical companies sent to general practitioners.

Methods
General practitioners in the Netherlands were recruited to collect all direct marketing mailings, meaning all leaflets, letters and other information sent by pharmaceutical industries to the practice during one month (June 2022). Direct marketing mailings and advertisements in collected medical journals concerning medicines or diseases (together called marketing materials) were analysed according to presence of one of the seven common persuasion strategies, i.e. reciprocity, consistency/commitment, social proof, liking, authority, scarcity and unity; as well as marketed medicine and year of introduction.

Results
Twenty general practices collected 68 unique marketing materials concerning 37 different medicines. Direct factor Xa inhibitors (n = 12), glucagon-like peptide-1 analogues (n = 5) and sodium-glucose co-transporter 2 inhibitors (n = 4) were the most frequently marketed medicines. The median year of introduction of all marketed medicines was 2012. All seven persuasion strategies were identified, with liking (64.7% of all materials) and authority (29.4%) as most prominent strategies, followed by social proof (17.6%), unity (14.7%), scarcity (13.2%), reciprocity (11.8%) and consistency/commitment (2.9%). In addition to those strategies, we identified emotional pressure (30.9%) as one commonly used new strategy.

Conclusion
Marketing materials sent to general practices use a wide range of persuasion strategies in an attempt to influence prescription behaviour. Primary care practitioners should be aware of these mechanisms through which pharmaceutical companies try to influence their attitudes towards new medicines.
Energy performance evaluation of a photovoltaic thermal phase change material (PVT-PCM) using a spiral flow configuration
Authors: Aziz Muhammad Syazwan Bin , Ibrahim Adnan , Ishak Muhammad Amir Aziat Bin 
Published: August 2023

A relatively new technology, a hybrid photovoltaic thermal (PVT) solar collector, allows for producing electrical and thermal energy. However, the module heats up more when exposed to sunlight thanks to the PVT collector's incorporation, reducing its efficiency. Consequently, lowering the operating temperature is crucial for maximizing the system's effectiveness. This research aims to create a photovoltaic thermal phase change material (PVT-PCM) solar collector and evaluate its energy performance through a controlled laboratory environment. Two different PVT collector designs, one using water and the other using a phase change material (PCM), were evaluated using a spiral flow configuration. Under a sun simulator, the PVT solar collector was subjected to 400 W/m2, 600 W/m2, and 800 W/m2 of solar irradiation at three different mass flow rates. The results showed that under 800 W/m2 of solar irradiation and 0.033 kg/s mass flow rate, the collector using water could only reach an overall maximum efficiency of 64.34 %, whereas the PVT-PCM configuration with spiral flow had the maximum performance, with an overall efficiency of 67.63%.
Structural Organization of Perisomatic Inhibition in the Mouse Medial Prefrontal Cortex
Authors: Nagy-Pál Petra , Veres Judit M. , Fekete Zsuzsanna , Karlócai Mária R. , Weisz Filippo , Barabás Bence , Reéb Zsófia , Hájos Norbert 
Published: August 2023

Perisomatic inhibition profoundly controls neural function. However, the structural organization of inhibitory circuits giving rise to the perisomatic inhibition in the higher-order cortices is not completely known. Here, we performed a comprehensive analysis of those GABAergic cells in the medial prefrontal cortex (mPFC) that provide inputs onto the somata and proximal dendrites of pyramidal neurons. Our results show that most GABAergic axonal varicosities contacting the perisomatic region of superficial (layer 2/3) and deep (layer 5) pyramidal cells express parvalbumin (PV) or cannabinoid receptor type 1 (CB1). Further, we found that the ratio of PV/CB1 GABAergic inputs is larger on the somatic membrane surface of pyramidal tract neurons in comparison with those projecting to the contralateral hemisphere. Our morphologic analysis ofin vitrolabeled PV+ basket cells (PVBC) and CCK/CB1+ basket cells (CCKBC) revealed differences in many features. PVBC dendrites and axons arborized preferentially within the layer where their soma was located. In contrast, the axons of CCKBCs expanded throughout layers, although their dendrites were found preferentially either in superficial or deep layers. Finally, using anterograde trans-synaptic tracing we observed that PVBCs are preferentially innervated by thalamic and basal amygdala afferents in layers 5a and 5b, respectively. Thus, our results suggest that PVBCs can control the local circuit operation in a layer-specific manner via their characteristic arborization, whereas CCKBCs rather provide cross-layer inhibition in the mPFC.SIGNIFICANCE STATEMENTInhibitory cells in cortical circuits are crucial for the precise control of local network activity. Nevertheless, in higher-order cortical areas that are involved in cognitive functions like decision-making, working memory, and cognitive flexibility, the structural organization of inhibitory cell circuits is not completely understood. In this study we show that perisomatic inhibitory control of excitatory cells in the medial prefrontal cortex is performed by two types of basket cells endowed with different morphologic properties that provide inhibitory inputs with distinct layer specificity on cells projecting to disparate areas. Revealing this difference in innervation strategy of the two basket cell types is a key step toward understanding how they fulfill their distinct roles in cortical network operations.
TOR‐mediated Ypt1 phosphorylation regulates autophagy initiation complex assembly
Authors: Yao Weijing , Chen Yuting , Chen Yingcong , Zhao Pengwei , Liu Jing , Zhang Yi , Jiang Qiang , Wu Choufei , Xie Yu , Fan Siyu , Ye Miao , Wang Yigang , Feng Yuyao , Bai Xue , Fan Mingzhu , Feng Shan , Wang Juan , Cui Yixian , Xia Hongguang , Ma Cheng , Xie Zhiping , Zhang Liqin , Sun Qiming , Liu Wei , Yi Cong 
Published: August 2023

AbstractThe regulation of autophagy initiation is a key step in autophagosome biogenesis. However, our understanding of the molecular mechanisms underlying the stepwise assembly of ATG proteins during this process remains incomplete. The Rab GTPase Ypt1/Rab1 is recognized as an essential autophagy regulator. Here, we identify Atg23 and Atg17 as binding partners of Ypt1, with their direct interaction proving crucial for the stepwise assembly of autophagy initiation complexes. Disruption of Ypt1‐Atg23 binding results in significantly reduced Atg9 interactions with Atg11, Atg13, and Atg17, thus preventing the recruitment of Atg9 vesicles to the phagophore assembly site (PAS). Likewise, Ypt1‐Atg17 binding contributes to the PAS recruitment of Ypt1 and Atg1. Importantly, we found that Ypt1 is phosphorylated by TOR at the Ser174 residue. Converting this residue to alanine blocks Ypt1 phosphorylation by TOR and enhances autophagy. Conversely, the Ypt1S174D phosphorylation mimic impairs both PAS recruitment and activation of Atg1, thus inhibiting subsequent autophagy. Thus, we propose TOR‐mediated Ypt1 as a multifunctional assembly factor that controls autophagy initiation via its regulation of the stepwise assembly of ATG proteins.
M‐CSF directs myeloid and NK cell differentiation to protect from CMV after hematopoietic cell transplantation
Authors: Kandalla Prashanth K , Subburayalu Julien , Cocita Clément , de Laval Bérengère , Tomasello Elena , Iacono Johanna , Nitsche Jessica , Canali Maria M , Cathou Wilfried , Bessou Gilles , Mossadegh‐Keller Noushin , Huber Caroline , Mouchiroud Guy , Bourette Roland P , Grasset Marie‐France , Bornhäuser Martin , Sarrazin Sandrine , Dalod Marc , Sieweke Michael H 
Published: August 2023

AbstractTherapies reconstituting autologous antiviral immunocompetence may represent an important prophylaxis and treatment for immunosuppressed individuals. Following hematopoietic cell transplantation (HCT), patients are susceptible to Herpesviridae including cytomegalovirus (CMV). We show in a murine model of HCT that macrophage colony‐stimulating factor (M‐CSF) promoted rapid antiviral activity and protection from viremia caused by murine CMV. M‐CSF given at transplantation stimulated sequential myeloid and natural killer (NK) cell differentiation culminating in increased NK cell numbers, production of granzyme B and interferon‐γ. This depended upon M‐CSF‐induced myelopoiesis leading to IL15Rα‐mediated presentation of IL‐15 on monocytes, augmented by type I interferons from plasmacytoid dendritic cells. Demonstrating relevance to human HCT, M‐CSF induced myelomonocytic IL15Rα expression and numbers of functional NK cells in G‐CSF‐mobilized hematopoietic stem and progenitor cells. Together, M‐CSF‐induced myelopoiesis triggered an integrated differentiation of myeloid and NK cells to protect HCT recipients from CMV. Thus, our results identify a rationale for the therapeutic use of M‐CSF to rapidly reconstitute antiviral activity in immunocompromised individuals, which may provide a general paradigm to boost innate antiviral immunocompetence using host‐directed therapies.